diff --git a/.gitignore b/.gitignore index 372ae82..d0c759a 100644 --- a/.gitignore +++ b/.gitignore @@ -146,3 +146,5 @@ testSQL.py /dist/ /static/ /templates/ + +.idea/ diff --git a/src/llm/README.md b/src/llm/README.md new file mode 100644 index 0000000..8c513e9 --- /dev/null +++ b/src/llm/README.md @@ -0,0 +1,97 @@ + +# πŸ“˜ EC Comment Vectorization - README + +## 🧩 Overview + +This project provides a script `ec_vector.py` that vectorizes enzyme comment data using a pre-trained sentence embedding model from the [Sentence-Transformers](https://www.sbert.net/) library. + +The input is a CSV file containing EC numbers and their functional comments. The script filters and processes records that have non-empty comments, converts them into dense vector representations, and saves the results in multiple formats for further analysis, visualization, or machine learning tasks. + +--- + +## πŸ“‚ Input + +The input CSV file must contain at least the following columns: + +- `ec_num`: Enzyme Commission number (e.g., `"1.1.1.1"`) +- `comments`: Descriptive comment text associated with the EC number + +πŸ“Œ The dataset used in this script is **`entry_with_comments`**, which has already been filtered to include **only rows where `comments` is not null or empty**. + +--- + +## βš™οΈ What the script does (`ec_vector.py`) + +1. Loads the input CSV using `pandas`. +2. Uses `SentenceTransformer('all-MiniLM-L6-v2')` to vectorize the `comments` column. +3. Constructs a result dictionary and a browsable DataFrame with embedding vectors. +4. Saves the outputs to multiple files: + - `.pkl`: Full Python dictionary with vectors and metadata + - `.npy`: Raw NumPy matrix for fast loading + - `.csv`: Full table with all metadata and embedding values per dimension + +--- + +## πŸ“„ Output Files + +### βœ… `ec_comments_vectors.pkl` + +- A Python `dict` serialized via `pickle`, containing: + - `'ec_numbers'`: List of EC numbers + - `'comments'`: List of corresponding comments + - `'embeddings'`: A NumPy array of shape `(N, 384)` representing each comment vector + +### βœ… `ec_embeddings.npy` + +- A NumPy `.npy` file containing only the embeddings: shape `(N, 384)` +- Useful for fast loading in numerical computing environments + +### βœ… `ec_vectorization_results.csv` + +This is a tabular file combining metadata and embedding values for easy inspection. + +#### πŸ”  Columns: + +| Column Name | Description | +|------------------|-----------------------------------------------------------------------------| +| `ec_num` | EC number (Enzyme Commission number) | +| `comments` | Functional description or comment for that EC | +| `embedding_dim` | Embedding dimensionality (typically 384) | +| `vector_norm` | L2 norm (magnitude) of the embedding vector (computed via `np.linalg.norm`) | +| `dim_0`...`dim_383` | The actual embedding vector, one dimension per column | + +This CSV is ideal for manual inspection (e.g. in Excel), visualization, or conversion to other formats. + +--- + +## 🧠 Model Details + +- Model used: [`all-MiniLM-L6-v2`](https://huggingface.co/sentence-transformers/all-MiniLM-L6-v2) +- Embedding dimension: `384` +- Encoding type: Mean pooling over BERT token embeddings + +--- + +## πŸ› οΈ How to Use + +### Run the script: + +```bash +python ec_vector.py +``` + +### Make sure the input CSV is correctly set inside the script: + +```python +csv_file = "entry_with_comments_202507250622.csv" +``` + +You will find the output files in the same directory unless otherwise specified. + +--- + +## πŸ“Œ Notes + +- Only EC entries **with non-empty comments** are processed. +- The script currently vectorizes only the `comments` field, but can be extended to combine or include `accepted_name`, `reaction`, etc. +- The `vector_norm` column can be used to analyze how β€œinformative” each comment is in embedding space. diff --git a/src/llm/__init__.py b/src/llm/__init__.py new file mode 100644 index 0000000..e69de29 diff --git a/src/llm/ec_comments_vectors.pkl b/src/llm/ec_comments_vectors.pkl new file mode 100644 index 0000000..958e6c8 Binary files /dev/null and b/src/llm/ec_comments_vectors.pkl differ diff --git a/src/llm/ec_embeddings.npy b/src/llm/ec_embeddings.npy new file mode 100644 index 0000000..472f614 Binary files /dev/null and b/src/llm/ec_embeddings.npy differ diff --git a/src/llm/ec_vector.py b/src/llm/ec_vector.py new file mode 100644 index 0000000..2b2cb31 --- /dev/null +++ b/src/llm/ec_vector.py @@ -0,0 +1,127 @@ +# import pandas as pd +# import numpy as np +# from sentence_transformers import SentenceTransformer +# import pickle +# import os +# +# +# def vectorize_ec_comments(csv_path, output_dir='vectors'): +# """ +# Vectorize EC records that have comments. +# """ +# # Create output directory +# os.makedirs(output_dir, exist_ok=True) +# +# # Read the CSV file +# print(f"Reading CSV file: {csv_path}") +# df = pd.read_csv(csv_path) +# +# # Check data structure +# print(f"Data shape: {df.shape}") +# print(f"Columns: {df.columns.tolist()}") +# +# # Filter records with non-empty comments +# df_with_comments = df[df['comments'].notna() & (df['comments'].str.strip() != '')] +# print(f"Number of records with comments: {len(df_with_comments)}") +# +# if len(df_with_comments) == 0: +# print("No records with comments found.") +# return +# +# # Load pretrained SentenceTransformer model +# print("Loading SentenceTransformer model...") +# model = SentenceTransformer('all-MiniLM-L6-v2') +# +# # Vectorize the comments +# print("Vectorizing comments...") +# comments = df_with_comments['comments'].tolist() +# embeddings = model.encode(comments, show_progress_bar=True) +# +# # Save results +# results = { +# 'ec_numbers': df_with_comments['ec_num'].tolist(), +# 'accepted_names': df_with_comments['accepted_name'].tolist(), +# 'reactions': df_with_comments['reaction'].tolist(), +# 'comments': comments, +# 'embeddings': embeddings +# } +# +# # Save the full result as pickle +# with open(os.path.join(output_dir, 'ec_comments_vectors.pkl'), 'wb') as f: +# pickle.dump(results, f) +# +# # Save only the embeddings as .npy +# np.save(os.path.join(output_dir, 'embeddings.npy'), embeddings) +# +# # Save index information as CSV +# index_df = df_with_comments[['ec_num', 'accepted_name']].copy() +# index_df.to_csv(os.path.join(output_dir, 'ec_index.csv'), index=False) +# +# # Done +# print("Vectorization complete!") +# print(f"- Embedding shape: {embeddings.shape}") +# print(f"- Saved in: {output_dir}/") +# print(f"- Files: ec_comments_vectors.pkl, embeddings.npy, ec_index.csv") +# +# +# if __name__ == "__main__": +# # Set your CSV file path here +# csv_file = "enzyme_data.csv" # Replace with your actual file path +# +# if os.path.exists(csv_file): +# vectorize_ec_comments(csv_file) +# else: +# print(f"CSV file does not exist: {csv_file}") +# print("Please generate a CSV file containing EC data first.") + +import pandas as pd +import numpy as np +from sentence_transformers import SentenceTransformer +import pickle + +# Load the CSV file (assumed to contain 'ec_num' and 'comments' columns) +df = pd.read_csv('entry_with_comments_202507250622.csv') # Replace with your actual filename + +# Load the pre-trained SentenceTransformer model +model = SentenceTransformer('all-MiniLM-L6-v2') + +# Vectorize the comments +print(f"Vectorizing comments for {len(df)} EC records...") +embeddings = model.encode(df['comments'].tolist(), show_progress_bar=True) + +# Save the results +results = { + 'ec_numbers': df['ec_num'].tolist(), + 'comments': df['comments'].tolist(), + 'embeddings': embeddings +} + +with open('ec_comments_vectors.pkl', 'wb') as f: + pickle.dump(results, f) + +np.save('ec_embeddings.npy', embeddings) + +# Create a DataFrame with vector information for inspection +# results_df = pd.DataFrame({ +# 'ec_num': df['ec_num'], +# 'comments': df['comments'], +# 'embedding_dim': [embeddings.shape[1]] * len(df), +# 'vector_norm': np.linalg.norm(embeddings, axis=1) +# }) + +vector_cols = {f'dim_{i}': embeddings[:, i] for i in range(embeddings.shape[1])} +results_df = pd.DataFrame({ + 'ec_num': df['ec_num'], + 'comments': df['comments'], + 'embedding_dim': [embeddings.shape[1]] * len(df), + 'vector_norm': np.linalg.norm(embeddings, axis=1), + **vector_cols +}) + +# Save to CSV +results_df.to_csv('ec_vectorization_results.csv', index=False) +print("CSV file saved: ec_vectorization_results.csv") + + +print(f"Vectorization complete! Embedding shape: {embeddings.shape}") +print("Saved files: ec_comments_vectors.pkl, ec_embeddings.npy") diff --git a/src/llm/ec_vectorization_results.csv b/src/llm/ec_vectorization_results.csv new file mode 100644 index 0000000..293983f --- /dev/null +++ b/src/llm/ec_vectorization_results.csv @@ -0,0 +1,6753 @@ +ec_num,comments,embedding_dim,vector_norm,dim_0,dim_1,dim_2,dim_3,dim_4,dim_5,dim_6,dim_7,dim_8,dim_9,dim_10,dim_11,dim_12,dim_13,dim_14,dim_15,dim_16,dim_17,dim_18,dim_19,dim_20,dim_21,dim_22,dim_23,dim_24,dim_25,dim_26,dim_27,dim_28,dim_29,dim_30,dim_31,dim_32,dim_33,dim_34,dim_35,dim_36,dim_37,dim_38,dim_39,dim_40,dim_41,dim_42,dim_43,dim_44,dim_45,dim_46,dim_47,dim_48,dim_49,dim_50,dim_51,dim_52,dim_53,dim_54,dim_55,dim_56,dim_57,dim_58,dim_59,dim_60,dim_61,dim_62,dim_63,dim_64,dim_65,dim_66,dim_67,dim_68,dim_69,dim_70,dim_71,dim_72,dim_73,dim_74,dim_75,dim_76,dim_77,dim_78,dim_79,dim_80,dim_81,dim_82,dim_83,dim_84,dim_85,dim_86,dim_87,dim_88,dim_89,dim_90,dim_91,dim_92,dim_93,dim_94,dim_95,dim_96,dim_97,dim_98,dim_99,dim_100,dim_101,dim_102,dim_103,dim_104,dim_105,dim_106,dim_107,dim_108,dim_109,dim_110,dim_111,dim_112,dim_113,dim_114,dim_115,dim_116,dim_117,dim_118,dim_119,dim_120,dim_121,dim_122,dim_123,dim_124,dim_125,dim_126,dim_127,dim_128,dim_129,dim_130,dim_131,dim_132,dim_133,dim_134,dim_135,dim_136,dim_137,dim_138,dim_139,dim_140,dim_141,dim_142,dim_143,dim_144,dim_145,dim_146,dim_147,dim_148,dim_149,dim_150,dim_151,dim_152,dim_153,dim_154,dim_155,dim_156,dim_157,dim_158,dim_159,dim_160,dim_161,dim_162,dim_163,dim_164,dim_165,dim_166,dim_167,dim_168,dim_169,dim_170,dim_171,dim_172,dim_173,dim_174,dim_175,dim_176,dim_177,dim_178,dim_179,dim_180,dim_181,dim_182,dim_183,dim_184,dim_185,dim_186,dim_187,dim_188,dim_189,dim_190,dim_191,dim_192,dim_193,dim_194,dim_195,dim_196,dim_197,dim_198,dim_199,dim_200,dim_201,dim_202,dim_203,dim_204,dim_205,dim_206,dim_207,dim_208,dim_209,dim_210,dim_211,dim_212,dim_213,dim_214,dim_215,dim_216,dim_217,dim_218,dim_219,dim_220,dim_221,dim_222,dim_223,dim_224,dim_225,dim_226,dim_227,dim_228,dim_229,dim_230,dim_231,dim_232,dim_233,dim_234,dim_235,dim_236,dim_237,dim_238,dim_239,dim_240,dim_241,dim_242,dim_243,dim_244,dim_245,dim_246,dim_247,dim_248,dim_249,dim_250,dim_251,dim_252,dim_253,dim_254,dim_255,dim_256,dim_257,dim_258,dim_259,dim_260,dim_261,dim_262,dim_263,dim_264,dim_265,dim_266,dim_267,dim_268,dim_269,dim_270,dim_271,dim_272,dim_273,dim_274,dim_275,dim_276,dim_277,dim_278,dim_279,dim_280,dim_281,dim_282,dim_283,dim_284,dim_285,dim_286,dim_287,dim_288,dim_289,dim_290,dim_291,dim_292,dim_293,dim_294,dim_295,dim_296,dim_297,dim_298,dim_299,dim_300,dim_301,dim_302,dim_303,dim_304,dim_305,dim_306,dim_307,dim_308,dim_309,dim_310,dim_311,dim_312,dim_313,dim_314,dim_315,dim_316,dim_317,dim_318,dim_319,dim_320,dim_321,dim_322,dim_323,dim_324,dim_325,dim_326,dim_327,dim_328,dim_329,dim_330,dim_331,dim_332,dim_333,dim_334,dim_335,dim_336,dim_337,dim_338,dim_339,dim_340,dim_341,dim_342,dim_343,dim_344,dim_345,dim_346,dim_347,dim_348,dim_349,dim_350,dim_351,dim_352,dim_353,dim_354,dim_355,dim_356,dim_357,dim_358,dim_359,dim_360,dim_361,dim_362,dim_363,dim_364,dim_365,dim_366,dim_367,dim_368,dim_369,dim_370,dim_371,dim_372,dim_373,dim_374,dim_375,dim_376,dim_377,dim_378,dim_379,dim_380,dim_381,dim_382,dim_383 +1.1.1.1,"A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.",384,1.0,-0.06853641,-0.021564182,-0.02363718,0.013699649,0.08611374,0.01814179,-0.009458703,0.009594991,0.017035035,-0.051809166,-0.018518955,0.021565612,-0.085403726,0.07892842,-0.029986843,0.027100498,-0.030999076,0.055908017,0.02277848,-0.0076346695,0.057019863,0.04289866,0.06198628,-0.030385694,0.006460782,-0.04651684,-0.03265916,0.07945535,0.03023947,-0.011473495,-0.02739943,0.06735954,0.041082416,0.014653567,0.012192704,0.048656225,0.000965718,-0.04999225,0.02444484,-0.018601574,0.12166169,0.047055345,-0.0035751436,-0.049673155,-0.036757056,0.035587527,0.008237526,-0.0028630055,-0.036267135,0.0010574732,-0.054510474,-0.08003527,0.016474532,0.05830837,0.026115268,0.05006779,-0.080825455,0.0029192404,0.016237391,-0.04453664,0.009231894,-0.030083783,0.005277382,0.040436693,0.081991136,-0.07183347,-0.016762337,0.006577066,-0.037981935,-0.07843656,0.017381234,-0.07862414,0.0064074793,0.034377165,-0.055625964,-0.068312764,0.01856513,-0.062345847,0.0470575,-0.04223268,-0.044236466,0.008455547,0.062204998,0.072240815,0.10688254,-0.016026542,-0.09833756,-0.014589262,-0.08721864,0.052294604,-0.02004546,-0.00090262695,0.04135502,-0.036788356,-0.014928423,0.02695398,0.057906136,-0.010274033,0.01507598,0.060923427,0.05773882,0.0885561,0.052657172,-0.118980624,0.010687695,0.057393953,0.025837433,0.019013245,-0.0246876,0.051508013,-0.012684432,-0.029196296,0.06340864,-0.05552165,0.0056551676,0.06481814,0.03695159,0.02374892,-0.056678157,-0.09470442,-0.059367258,-0.0069849812,0.04870636,0.020696234,-0.015575346,0.1068096,-0.06753185,-3.0120188e-34,0.0101442095,-0.05537374,-0.07134172,0.0074259983,-0.0074237264,-0.022137802,0.004676978,0.044103544,0.010067731,-0.031363577,-0.04300872,0.014386488,0.04583722,0.044965446,-0.00081420346,-0.06661449,0.06404077,-0.044454485,0.09286715,0.045651585,-0.0051312665,0.03668011,-0.063996725,-0.015848897,0.03883586,-0.024057236,-0.010963302,-0.029365279,-0.0471326,-0.0007694014,-0.030451614,-0.019534905,-0.06241645,0.0014231034,0.14914669,0.044831023,-0.0034771285,-0.014484556,-0.039056417,-0.06271174,0.013292971,-0.004052011,-0.04916305,0.03617398,0.054232962,0.016947942,-0.106085435,0.060594,0.016410524,-0.053152468,0.047798157,-0.020290144,0.0870416,-0.03920409,-0.12806484,0.059761867,-0.03514412,-0.011968636,0.028863207,0.045125633,-0.057078164,0.032610424,-0.09477766,0.10330476,-0.0036031473,0.00092417764,-0.12259299,-0.11303203,-0.020751996,0.06465321,-0.071576186,0.00829645,0.06682683,-0.027026413,0.015451068,-0.03018693,-0.01094312,-0.031064225,0.09627291,0.013076672,-0.01051228,-0.094124824,-0.012587659,-0.032992996,-0.059169553,-0.06387157,0.009376034,-0.091297776,-0.0021032563,-0.04961489,0.061273564,-0.06319487,0.028050566,0.020920957,0.07332678,-2.5543404e-33,0.031041326,-0.011279486,0.06073415,-0.06321623,-0.021237321,0.036516067,0.041033328,-0.11230352,-0.030827401,-0.03365667,0.10518219,-0.025594259,0.0081327595,-0.006114039,0.04429392,0.06878364,-0.10575487,0.07111749,0.034147467,-0.031777654,-0.02334903,0.083291896,0.033560477,0.030914871,0.036491774,0.039246563,-0.085340746,0.039990287,0.034561902,0.048422325,-0.035971522,-0.0051542674,0.036046676,-0.07839734,-0.043674435,0.03684206,-0.058504622,-0.087107375,-0.07457682,-0.03669602,0.060579754,0.009038152,-0.04798818,0.055738024,0.08459983,0.08045373,-0.08688485,-0.020967826,-0.10691502,-0.054265756,0.05968482,0.0439736,-0.040013313,0.026708072,0.067644864,0.062199846,0.02780998,-0.014046147,-0.03136926,-0.0006235879,-0.018224789,0.0037162441,0.011790578,0.061257496,0.0060087694,-0.03701997,-0.025758462,0.03822839,0.01935452,-0.00155374,0.072176404,0.12713024,0.06909143,0.007731403,-0.03178663,-0.026575986,-0.041581284,-0.034638286,-0.050783705,-0.01041689,-0.0504232,0.030445257,-0.007923355,0.06653782,-0.044730064,-0.060724203,0.018423108,0.036849946,-0.04268486,0.041174937,-0.03377715,-0.0072287503,-0.06939857,0.064043134,-0.06550101,-3.3971318e-08,-0.03797316,-0.006248328,0.05186404,-0.035592984,-0.017959002,-0.01666418,0.032541748,-0.06362503,0.013853973,0.0009748732,-0.031299926,0.12424052,0.0127964625,-0.021599818,0.02697146,0.014705973,-0.02821613,-0.031810902,-0.027602602,0.047277585,0.04542249,0.056198984,-0.04071796,0.10617765,-0.033070326,-0.11624583,-0.02068217,0.09440297,0.008682252,-0.036146313,-0.015147316,0.06361481,0.012558699,0.0047068475,-0.07132712,0.008703059,-0.033264074,-0.11419061,-0.06811847,0.009215555,-0.028564857,-0.038905352,-0.06485592,-0.015260826,0.0041151918,-0.09847314,0.00803405,0.014901033,0.04332983,0.04352203,0.0070954836,0.032876935,-0.031899296,-0.001215792,-0.019585563,-0.021173753,-0.051426984,-0.019684095,-0.050596215,-0.079857506,0.0513851,0.0028623333,0.15765502,-0.017077798 +1.1.1.2,A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19 (L-glucuronate reductase) and EC 1.1.1.55 [lactaldehyde reductase (NADPH)]. Re-specific with respect to NADPH.,384,1.0,-0.06045708,-0.02773995,-0.030241098,0.050359514,0.11670032,0.046036426,0.013956608,0.0054829395,0.042179897,-0.06551982,0.002191887,0.020331213,-0.060566142,0.055891484,-0.04998305,-0.023374377,-0.06482223,0.03458351,-0.032584652,0.00015496157,0.019712996,0.0152525045,0.06944498,-0.015305165,0.109021425,0.014421717,0.0010501919,0.08106821,-0.008665334,-0.11019364,-0.020623956,0.0009914525,0.019613933,-0.013986509,0.028759426,0.041288394,-0.035277233,-0.0503115,-0.026915425,-0.016058955,0.05951395,0.053822026,-0.014139675,-0.025771465,-0.03255845,0.039083865,-0.023412837,0.06057555,-0.037750937,0.06394772,0.022273783,-0.06442216,0.0064274524,0.08153038,0.11466919,0.019096257,-0.075890705,0.023948513,0.0065907305,-0.053348087,0.04265627,-0.047790464,0.007955563,0.007989043,0.021093775,-0.020670952,0.07530443,-0.044071656,-0.055519708,-0.083478376,-0.047165368,-0.07913974,0.04284029,0.052636243,-0.03829346,0.03673124,-0.013181481,-0.078702696,0.017032925,0.027424209,-0.0067235013,0.012244194,-0.019586977,0.12054224,0.10671064,-0.02630155,-0.06823635,-0.025419626,-0.08014503,0.022921057,-0.03671075,0.030233018,0.04872359,-0.027435225,-0.06459524,0.058340844,0.028821794,0.060346417,0.011504856,0.0065324986,0.022974953,0.14331254,0.048204936,-0.10393187,-0.043379065,0.037838444,-0.0035059748,0.09031803,-0.042519487,0.0070980233,-0.014835272,-0.020549485,0.03220416,-0.061225627,-0.0163761,0.07742307,0.03197135,-0.007927924,-0.13752206,-0.035511248,-0.041071888,-0.0074795503,0.049184456,0.02953464,-0.034809954,0.0321507,-0.10731915,3.1593615e-34,0.05556873,0.0043208175,-0.026465548,0.0008774862,0.031383954,0.0141122155,-0.06313397,0.07014139,0.032259397,-0.07629553,-0.041925617,0.0061635072,0.044409983,-0.036803126,-0.022473563,-0.0060135513,0.011960309,-0.053749554,0.012965301,-0.01257619,0.009499505,0.07508981,-0.062351238,-0.006360384,0.02907404,-0.033672355,-0.023447094,-0.031767566,-0.04105475,-0.003536521,-0.0068671647,-0.036139317,-0.09143238,0.023145325,0.05788268,-0.008786341,-0.0007389782,-0.04188987,-0.008527536,-0.03276362,-0.015081789,0.040068537,-0.038238384,0.001155325,0.048934203,-0.06742,-0.091830395,0.06407033,0.027291005,0.0011308513,0.036263034,-0.03719879,0.06912539,-0.05091847,-0.12459039,0.04313088,-0.06387892,0.009599125,0.009378529,0.06802682,0.032899503,0.076642364,-0.09184953,0.06889669,-0.006007678,0.020141514,-0.098561995,-0.07433682,-0.04286566,0.016568786,-0.02733872,-0.00977858,0.08955316,-0.01114217,-0.025877595,-0.019001344,-0.04298942,-0.011892741,0.05600126,0.028334526,-0.079792514,-0.06922461,-0.06749212,-0.023491932,-0.06382807,-0.041123,0.039799154,-0.08302491,0.010504512,-0.007633923,0.06634358,-0.06468219,-0.026060266,-0.060944315,0.0038561078,-2.686077e-33,0.07221622,-0.040548492,0.065300874,-0.081283756,0.053717557,0.010660237,0.082821235,-0.053143717,-0.00062373566,-0.0546813,0.08676414,-0.022287337,-0.01106628,-0.018836912,0.06504932,0.03142567,-0.07198163,0.09329887,0.046426862,0.0066887476,-0.0035342972,0.08801525,0.05820397,0.04009497,0.04177963,0.018494813,-0.049385197,0.0009969554,0.04810083,0.054131813,-0.04629772,0.05356588,0.01271504,-0.06822043,-0.029065074,0.03877978,-0.09003286,-0.051428534,-0.050888874,-0.015038699,0.040612247,0.0020086295,-0.07350043,0.04663459,0.12494852,0.022900144,-0.091048785,-0.014469545,-0.003875822,-0.06883407,0.06603597,0.06301446,-0.05067276,0.04997548,0.064522624,0.0508082,-0.014175564,0.018062359,0.017901164,0.054305,-0.014762842,0.008850553,-0.0076397727,0.028120203,0.016119368,-0.07778361,-0.040896855,0.043236714,0.011136532,0.030108579,0.08984488,0.037406866,0.027691199,0.044097584,-0.03824202,-0.10521489,-0.08385404,0.028012302,-0.0834045,-0.026477596,-0.0042028786,0.04839179,-0.01737814,0.06492266,0.00086938415,-0.022119459,0.047178436,0.053455126,-0.030480985,0.025791476,-0.06588091,-0.00826321,-0.07181885,0.12258307,-0.05967897,-4.0578133e-08,0.00029510653,0.027121877,0.082731314,-0.0040010223,0.028640008,0.0041329865,0.04561974,-0.033103168,-0.00793594,-0.008260514,0.04308196,0.14358757,0.046580154,-0.051313426,0.007246079,0.009314004,-0.07136855,0.0016368447,-0.01629463,0.037304346,0.015467924,0.02209942,-0.05415356,0.07200841,-0.039384946,-0.064950906,0.0013423697,0.009070772,0.016233662,-0.09682397,0.02255106,0.023695694,0.068427645,-0.036338083,-0.07387656,-0.0019764926,-0.0293424,-0.03698327,-0.0861703,0.04365705,-0.08849278,-0.07484,-0.048008002,0.023483051,0.015988158,-0.071029864,0.016572531,-0.030215446,0.0075803814,0.022156103,0.017037679,-0.0016341772,-0.06762287,-0.04658637,-0.039741844,0.014066036,-0.040247455,0.017537879,-0.009043284,-0.102350034,0.07370778,0.016985605,0.14334708,-0.007255286 +1.1.1.3,"The yeast enzyme acts most rapidly with NAD+; the Neurospora enzyme with NADP+. The enzyme from Escherichia coli is a multi-functional protein, which also catalyses the reaction of EC 2.7.2.4 (aspartate kinase).",384,0.99999994,-0.044223752,-0.053994935,-0.027172416,0.010358427,0.036783665,0.08240991,-0.079446115,0.03105595,0.07349223,0.020543467,0.028012635,-0.017600194,-0.1330388,0.06588962,-0.026977574,0.008045038,-0.017817097,0.01063424,0.022395527,-0.059028786,0.054158185,-0.019852195,0.038200557,-0.05970823,0.06674805,0.0027167236,0.008765297,-0.016091371,-0.00012550228,-0.11628929,-0.009521798,-0.02415089,-0.016919658,-0.030358024,-0.024526324,0.071866326,-0.046019483,-0.09252725,0.03380193,-0.009044771,0.010273723,-0.008392793,-0.06442547,0.008611197,0.008659991,0.017403407,0.06434672,0.03647706,0.08368144,-0.080275334,-0.0510944,-0.01363705,0.011133948,0.0021305894,0.011623578,0.022673441,-0.03283589,-0.055259276,0.016231254,-0.042457037,0.0033319343,-0.037911285,0.025428379,0.029595874,0.07794057,-0.05070727,0.051457796,-0.029190952,-0.039920814,0.022369044,-0.12875819,-0.01844792,0.009195368,0.0387249,0.040697794,-0.006836738,-0.04555333,-0.05950505,0.06940516,0.0055733374,0.05889563,0.027017089,-0.023345422,0.0108410595,0.091486044,-0.009221315,0.017047513,0.07063326,0.013143414,0.0419967,-0.03445913,-0.025067398,0.022755662,-0.0042549577,-0.12760803,0.042521954,-0.011861955,0.052856002,0.030723028,-0.04330675,0.008357159,0.15235135,0.02907637,-0.044437427,0.037310895,0.037479717,0.004146112,0.13250832,0.017777678,0.03340357,-0.020852592,-0.05453284,0.025051631,-0.02867992,-0.030008014,0.078416556,0.022837065,-0.0044612144,-0.053094897,-0.011260844,0.027006652,-0.017420605,-0.048331782,0.047274057,-0.0446345,0.06599245,-0.12116335,2.5701902e-34,0.05295038,-0.0040148115,-0.03816316,-0.009082432,0.015202252,-0.0068179565,-0.038460884,0.04134806,-0.04037863,-0.0418751,-0.033520225,-0.111682735,0.047228016,0.078210846,-0.04230727,-0.009754231,-0.00096556376,-0.02839973,-0.0059025455,0.029060699,0.057977147,0.040839624,-0.0054632984,0.035153817,0.07034302,-0.0039862553,-0.072432324,0.084231146,-0.037889857,-0.02419369,0.014986537,-0.09145675,-0.14149994,0.048494153,0.08791373,-0.05480328,0.01294926,-0.04684314,0.013521644,0.036030147,-0.11561338,0.06588005,-0.046808206,-0.028105881,0.01674303,-0.026680294,-0.020745885,0.066519655,0.0936813,0.045773335,0.0401886,-0.046405625,0.1206112,-0.038913522,0.021605968,0.08219429,-0.03811395,0.03538184,0.024288861,0.08866864,-0.045532886,0.041687697,-0.05191383,0.07203402,-0.024527865,0.05577695,-0.04337479,-0.041548625,0.055785265,0.043040648,-0.05896585,0.07990186,0.043577384,-0.020808063,0.007970346,-0.042111307,-0.0396078,-0.07951815,-0.023642818,0.058395125,-0.03838326,-0.06758876,-0.02909187,-0.0036845293,-0.030154997,0.054495744,0.029782806,-0.026024986,0.006383701,0.035904877,0.020628968,-0.05342726,0.009654061,-0.008788007,0.078168705,-1.357364e-33,0.12424039,-0.051709797,0.07281937,-0.086903304,-0.10765463,0.1230145,0.0035904727,-0.0932779,-0.06965466,-0.009065659,0.0081705,0.008038614,0.0541563,-0.03332232,-0.0037381663,-0.0047430373,-0.054200545,0.06697024,0.0107633835,-0.03318798,-0.005612997,0.14390285,0.0047501326,0.01265156,0.06711254,-0.0068781613,-0.055515543,0.08373465,-0.030289402,0.032620575,-0.05245335,-0.006450412,-0.04465339,-0.053642783,0.014148998,0.037148558,-0.0795379,-0.028038938,-0.0026892202,-0.0066666827,0.08614732,0.06715625,-0.054784633,0.05887678,0.004811241,0.046137705,-0.08761086,0.010282796,0.029646154,-0.07499032,-0.0030548994,0.010292233,-0.047767613,0.01715286,0.054228093,0.0331778,0.017695032,0.006019506,0.041832864,-0.004672868,-0.054923125,-0.073034756,0.06702243,-0.030514965,0.08952855,-8.840937e-05,-0.057606764,-0.0008129882,0.053028177,0.005927363,0.03795396,0.073555,0.010898399,0.051343206,-0.013648503,-0.03988345,-0.08289212,-0.035992365,-0.00095563533,-0.009081204,0.0032495407,0.0086174095,-0.03773372,-0.041092116,-0.06748668,0.028680954,0.007900834,0.048044916,-0.029032722,0.0036517757,0.0006831087,0.035173707,-0.013266949,0.07881389,-0.021820117,-3.2356294e-08,0.074735045,0.017903352,0.070380956,-0.10695606,0.07174419,0.06161694,0.027203742,-0.016124591,0.011238138,0.033994745,-0.020261427,0.103488654,0.0772895,0.02725558,0.032359548,-0.01761013,-0.019916512,0.012464616,-0.025889914,-0.03596441,-0.0063367137,-0.018037029,-0.097381294,0.10475289,0.0453278,-0.06402697,0.034110676,0.02871309,0.019248698,-0.060884364,-0.06181595,-0.022519674,0.03371622,-0.006908462,-0.038107824,0.015129813,-0.07096913,-0.046883907,-0.025021024,0.029157134,0.01146133,-0.061943326,-0.034456946,0.004072709,-0.07327664,0.03661385,0.0584764,-0.064475656,-0.038780145,-0.004366945,0.08203928,-0.06329609,-0.0042632683,-0.0028804932,-0.10127454,0.009804342,-0.051304933,-0.07068447,0.014890902,-0.05643986,0.042186692,-0.025131391,0.10696661,-0.057986263 +1.1.1.4,Also converts diacetyl into acetoin with NADH as reductant.,384,1.0,-0.015573056,0.020206654,-0.12629925,-0.010001667,-0.053084217,-0.010053275,0.012221853,0.06045125,0.035619892,-0.045366265,-0.023048365,0.002590974,-0.055484533,0.0023933179,-0.03655361,0.015665986,0.030178854,0.0940598,-0.028171834,-0.067838445,0.038185682,0.041173894,0.008182853,-0.005291437,0.029938092,0.00453276,0.023195924,0.0056203003,-0.026251331,-0.13365458,-0.07229689,0.008303355,-0.0028538322,-0.05275445,-0.014349155,0.047869343,-0.036828022,0.05343799,0.008595217,0.034792952,0.05656091,-0.039853834,-0.02359718,0.035917398,0.0020901777,-0.037877347,-0.09404338,0.070737764,0.07640722,0.048710786,-0.04204416,0.022100342,-0.053508226,0.03751183,0.036239143,0.037431333,-0.031210564,-0.00981934,-0.010861285,-0.021401266,-0.010443128,0.018173387,-0.058860864,-0.042356405,-0.008474785,-0.036485434,0.04093902,-0.08526749,-0.03217678,-0.04274564,-0.065147445,-0.07088084,0.018807974,0.07057601,0.0077527403,-0.0063228575,-0.0461918,0.02808352,0.05329237,0.026893819,0.07983317,0.1082653,-0.039184246,0.060773034,0.101362534,0.07512492,-0.05500121,-0.05654001,-0.0339972,-0.023995599,-0.010415191,-0.052823167,-0.055036336,-0.0070362175,-0.07634496,-0.07300007,0.0041430476,-0.011603016,-0.006684038,0.003332426,-0.007193427,0.082218155,0.007837078,-0.086472094,-0.12126534,0.009754544,0.002660473,0.05427009,0.04622168,-0.0054841707,-0.028575506,0.0032213717,0.021600349,-0.047494605,-0.061205935,0.1266703,-0.03608825,-0.031192148,-0.019597664,-0.01632969,0.023314051,0.01540717,0.033659544,0.074324265,0.023864582,-0.044351727,0.01666068,3.361422e-33,0.035236705,0.048014533,0.052376136,0.041234396,0.024838306,0.01123717,-0.10121134,-0.017328473,0.10749021,-0.09133271,-0.015253038,-0.10374012,0.017162792,0.015447766,-0.052383315,-0.001046023,-0.03276312,-0.052700642,-0.013226605,-0.01716132,0.00255403,0.09661517,-0.060991514,0.0142886005,0.013085511,0.04728248,-0.0049549276,0.08110788,0.045133907,0.009013723,0.07684259,-0.0155769745,0.007806653,0.008438904,-0.06371404,0.069512054,-0.016616844,-0.05355432,0.022776047,0.12555943,-0.03158241,0.026314845,-0.04401249,0.012568717,0.030608162,-0.10695908,-0.030557686,0.04579914,0.02516081,0.015779441,0.016679164,-0.05334466,0.08546588,0.019059392,-0.033751883,0.0071017705,-0.07824854,-0.016134344,0.03627425,0.11549122,0.038208522,0.06397032,0.009990219,0.027080735,-0.09401628,0.014971309,-0.09120395,-0.062268417,-0.03346854,0.023091761,-0.012664969,0.01573034,0.11613618,0.03955356,-0.00917781,-0.07048733,0.035055142,0.049822636,0.090632886,-0.07666015,0.05987207,-0.064040706,0.020525094,0.005192251,-0.008557892,0.011979583,0.015618582,-0.0927263,-0.01807851,0.018981876,0.030983876,-0.015194909,-0.013939153,-0.042606782,0.06822301,-4.35299e-33,0.05035304,-0.05101902,-0.0003394921,0.0053986576,0.007509046,0.04504627,0.03657065,-0.058363426,-0.05004836,-0.040483702,0.051841132,0.004274573,-0.03523036,-0.00996659,0.050817844,-0.043009028,-0.014322651,0.047664072,-0.061116185,0.08099654,-0.02968073,0.07765074,-0.015285527,0.009029395,0.09031193,-0.016601965,-0.06888512,0.031951547,0.01593091,0.052728243,-0.014385713,-0.0037001688,-0.1183725,-0.060982957,-0.07527884,0.04022189,-0.037452232,0.021411039,-0.11578224,-0.017610094,-0.058763474,-0.04357916,-0.050610762,0.0145306,0.07112583,0.046410386,-0.003321262,-0.009436052,0.0107184425,-0.05637721,0.08378683,0.03905206,-0.027269404,0.018994752,-0.0086354725,0.060173932,0.022913849,-0.031338792,0.06816307,0.011595488,-0.0793349,-0.07805264,0.020601587,-0.04608987,0.09322766,-0.019198952,-0.010745489,0.12130415,0.063629545,0.013399421,0.05490755,0.031690218,0.08517704,0.0919905,-0.015508596,-0.087613,-0.028812556,-0.06666782,-0.08146148,-0.0510546,-0.07572744,-0.059032936,-0.03553201,-0.069585666,-0.059878863,0.0011484199,0.017855546,0.017730193,-0.07587501,0.06233786,-0.03919079,-0.025070721,-0.058988675,0.033188283,0.027479047,-2.1504704e-08,0.095342666,-0.019577788,0.034260035,-0.011311755,-0.0360123,-0.008069902,0.08166676,0.0007735371,-0.015247615,-0.02227913,-0.08464214,0.17750572,0.068873435,0.025220178,0.026753008,0.07466734,0.027264312,0.050932772,0.0094004255,-0.017053263,-0.0689203,0.014011784,-0.0667417,-0.017476428,0.018224671,-0.04530962,0.024338216,0.1091452,0.034735274,-0.067701444,0.04084269,0.008101269,0.0692834,-0.060227193,0.012626047,0.020202756,-0.01657847,0.07565962,0.016451005,-0.02666584,-0.032212835,-0.02499387,-0.028893238,0.056949846,-0.034777444,-0.04428941,0.045378547,-0.016484883,0.009350376,-0.01136174,0.04111457,0.0022022815,0.012146354,-0.10153805,-0.041369997,0.042657103,-0.010131381,-0.04676767,0.05253559,-0.010547634,-0.0021466261,-0.013523618,0.12059461,0.04703816 +1.1.1.5,NADP+ also acts as acceptor.,384,0.99999994,-0.11305673,0.016565438,-0.04425752,0.01927445,-0.0027601528,0.03777958,0.020704696,0.014741642,0.055481195,0.038790077,0.05125243,0.007066874,-0.05919007,0.06488923,-0.031259283,0.053335644,-0.030639417,0.016226346,0.03834958,0.04866083,-0.032443557,-0.02109494,0.041062325,-0.066421665,0.03670528,-0.0024166664,-0.03151583,-0.0022244796,0.07829297,-0.071259625,-0.03426781,0.040580545,-0.0056373957,0.0063674017,-0.090575285,0.065013126,-0.048098292,-0.004227349,-0.0618806,-0.03770103,0.011753832,-0.017340537,-0.0724381,0.035290767,-0.026379863,-0.07344128,0.027095988,0.039084353,0.0025901373,-0.05973838,-0.030799298,0.03644957,0.002374771,0.025020873,-0.0044856886,0.0015321703,0.0048185796,-0.04690064,-0.0343841,-0.10971716,-0.04917682,-0.03203225,-0.06751328,0.03452852,0.060054377,0.00308711,0.04530535,-0.0032487377,-0.075425655,0.002330823,-0.054386202,0.012139464,0.030235786,0.013977887,0.03267748,0.03428601,-0.07341063,0.0016478159,0.10277625,0.07889076,0.004349605,0.06617102,-0.08367967,-0.006160512,0.10258712,0.019882537,-0.07851576,0.01369879,-0.016299414,0.017668892,-0.03641715,-0.02629079,-0.006758755,0.07678153,-0.03540319,-0.021483574,0.031233048,-0.009716457,-0.0416083,0.009657113,-0.022227336,0.09006713,-0.07714756,-0.015524552,-0.01273786,-0.025036639,-0.009776742,-0.0036265508,-0.0355041,-0.025889287,-0.08027791,-0.096040815,0.054467343,-0.014395388,-0.037514128,0.12517683,-0.023164263,-0.018288963,-0.018230665,-0.117618844,-0.03706707,-0.0018864011,0.0016502715,0.013057954,0.0059148655,-0.01251236,-0.05162293,-1.675192e-33,0.038465347,0.012553334,-0.018876025,0.018825427,0.03464205,0.070962675,-0.052733116,0.000367099,0.013035956,-0.074725695,-0.07438172,-0.10073446,0.05675929,0.070149206,-0.0023784388,0.044251293,-0.033130143,0.011157547,-0.0017891162,-0.08134573,0.034027886,0.1380727,-0.028153263,0.018562986,0.008809386,0.04299218,-0.02340739,0.07456777,-0.013548413,-0.004223969,0.107812166,-0.04741488,-0.09729896,0.065158665,0.018113313,0.06846235,-0.03198291,-0.059943613,0.000115355804,-0.018971596,-0.105850875,0.06599649,-0.08174083,-0.0049082036,0.01156168,-0.099358685,0.007424297,-0.006686749,-0.0017603296,0.027783863,-0.006692181,0.008098476,0.059730627,-0.06870054,-0.009469399,0.05555498,0.028504135,0.07045437,-0.074601635,0.07960124,0.008559013,0.043623928,-0.010343115,0.027042108,-0.11627857,0.05448024,-0.0914651,-0.1290538,0.076876834,0.0718425,0.0024189076,0.07197968,-0.011578459,0.06430194,0.045806974,-0.085466534,0.017366204,-0.014416108,0.037666667,0.037473075,-0.071857296,-0.059001062,-0.042045977,0.05966053,-0.041181438,-0.02055782,0.03349155,-0.055567544,0.079127625,0.033722866,0.061931152,0.020560786,0.0019253397,-0.0021948165,0.0795048,-5.045712e-34,0.033160824,-0.025856437,0.012525686,0.004922876,0.01065956,0.0780738,0.020499745,-0.123717695,0.036435734,-0.07495708,0.061119374,0.086945996,0.041348346,0.024581362,0.050439667,-0.051768348,-0.033319693,0.013910468,-0.027178196,0.0060357433,0.020066876,0.123353995,0.029568354,-0.039400067,0.03169607,-0.028068291,-0.055618674,0.024663525,0.035113327,0.014165386,-0.019314831,0.035682455,-0.13958344,0.001267295,0.04961889,0.012741141,-0.05760484,0.034468554,-0.06941401,0.043913543,0.018313136,-0.041308574,-0.06475,0.079095736,0.045483306,-0.0331314,0.020818349,-0.017420532,0.032259103,-0.0733322,0.0203518,0.10391439,-0.008686165,0.013663525,0.10054499,0.08747554,0.025341835,-0.02841057,0.060782414,0.008912663,-0.032980353,-0.07954987,0.04457725,-0.0038675484,0.06807844,-0.01185796,0.016522277,0.01749244,0.10826181,-0.06510795,0.08705643,-0.0232201,0.0014098559,0.05677796,0.05427053,-0.04832414,-0.10308882,-0.0031405282,-0.023121506,-0.058803078,-0.111411884,-0.00013149592,0.012665061,-0.05484073,-0.01979374,-0.036135014,0.0036034284,-0.036302753,-0.014745698,0.008710465,0.051051352,0.063435465,-0.008286646,0.031840667,-0.04527885,-1.7029311e-08,0.0011118017,-0.028251199,0.027151413,-0.058343768,-0.002840856,-0.0024431963,0.019522063,-0.09141075,-0.05660641,0.046774525,0.049426865,0.14525,0.08231697,-0.044266038,0.093153,-0.018667405,-0.006568211,-0.024183327,-0.07409375,-0.0066616745,-0.06029867,0.029416902,-0.049968056,0.023962779,-0.0121776685,-0.0100570265,-0.0076160557,0.005760971,0.042536125,-0.029611131,0.06664532,0.021759726,0.056620196,-0.0032768387,0.003021691,0.107587956,0.024399607,-0.004163513,-0.0025897669,0.07947592,-0.001876392,-0.06275669,-0.03251627,0.03944585,-0.011871263,0.11151069,0.032985773,-0.06318342,-0.08666259,-0.036507692,0.06519336,-0.001284263,0.03014058,-0.041769933,-0.025127541,0.016655834,-0.023492098,-0.048624102,0.042406574,-0.052883036,0.038140558,-0.013770433,0.059791412,-0.010903632 +1.1.1.6,"Also acts on propane-1,2-diol.",384,1.0,-0.04218592,-0.04921515,-0.047451433,0.02706934,0.11845719,-0.05777243,0.0055966647,0.04109559,0.058019266,-0.046027098,0.034629293,0.021843055,-0.08453962,0.06419762,0.06699769,0.0143379,-0.023510905,-0.055595294,0.016764594,-0.039586138,0.043944947,-0.012839633,0.0138352085,0.017898101,-0.067237124,0.027041987,-0.030596517,0.09450184,0.067280024,-0.07270482,0.014799474,0.030167123,-0.10042421,-0.038654078,-0.02164874,0.02708328,-0.06015012,0.07105224,-0.022605559,0.0047078207,0.07416676,-0.06751564,0.04626379,-0.037551694,-0.03102456,-0.026279613,-0.05924415,0.06616822,0.028931616,-0.037839685,0.019344546,0.0037147857,-0.021810722,0.03525295,0.06660473,0.0076248534,-0.08009199,0.07312708,0.023974366,-0.057454858,-0.0012897272,0.09078992,-0.13288201,0.07016849,-0.036551245,-0.010929253,0.063817225,-0.083410196,0.014932332,-0.04181309,-0.05611217,-0.06637818,0.052233398,-0.07041239,0.03698713,-0.0071326103,-0.033110216,-0.041690588,0.004705805,-0.06894604,-0.0054576793,-0.03268415,-0.03996998,-0.063775696,0.008152033,0.05919974,-0.021239942,-0.0784227,0.03709232,-0.0438023,-0.01673835,0.01954283,0.040063284,0.047315337,-0.0043395604,0.06129235,0.035408128,0.060806982,-0.030942997,0.037592087,-0.03097267,0.06525613,-0.09837431,-0.040607102,-0.04977243,0.023316562,0.043394297,0.025636131,-0.027700167,-0.015593874,-0.051487397,-0.02732656,0.08777412,0.0139360195,-0.025989778,-0.05961469,0.030855417,0.004911304,-0.012646517,-0.06208871,0.053803097,-0.03301848,-0.04589031,0.01290221,-0.056315593,0.041538708,0.03590278,-1.984383e-33,0.0026924668,0.0031839763,-0.018766748,0.02953187,0.071984105,0.03247266,-0.065365694,-0.0063407123,-0.040752083,0.050925754,0.058719803,-0.008362958,-0.037444167,0.058355134,-0.05033794,-0.09351958,0.06185212,0.037774116,0.041840874,-0.04645359,-0.0036082484,0.09486318,-0.036342017,0.0032212683,0.0436797,0.03467532,0.0030935255,0.0125812255,0.027985971,-0.010774888,0.067396395,-0.011911444,-0.07827766,0.061010342,-0.034177743,0.042814117,-0.089159526,4.326763e-05,-0.046402384,-0.021036448,-0.029770829,0.035633925,-0.0920935,0.019467002,-0.011152951,-0.051926155,-0.04225121,0.100890696,0.0031307156,-0.012634225,-0.0036170764,0.024406888,0.013560853,-0.031521842,-0.019562848,0.020376386,0.080083966,0.0031397818,0.052499946,-0.0020818978,-0.060879257,0.10780854,-0.041763783,-0.060533624,0.014874543,-0.024496045,-0.060251098,-0.005648438,0.073836006,0.006898645,-0.07808741,0.057870675,0.07076051,-0.032807097,0.06317663,-0.01576213,0.004074513,-0.043268,0.05492443,0.013537106,-0.06672914,-0.08350802,0.082162976,0.041170985,-0.045072373,-0.044262554,-0.047200434,-0.09415766,-0.02179721,0.007988531,0.0295457,-0.025590902,0.06576767,0.01650644,0.084230125,3.7041526e-34,-0.05902128,0.008266394,0.013869618,0.051512178,0.013944022,0.027078137,-0.006327523,-0.0815593,0.039891317,-0.035689376,0.09890731,0.0086713955,-0.030668559,0.005782228,0.02971342,0.041699957,-0.01558459,0.03324499,0.024897091,0.035378538,-0.027353074,0.091474265,-0.026360262,0.10960451,-0.03612849,0.039382573,0.041695636,0.0043831626,0.0020554857,0.057213742,0.024715858,0.060646147,-0.023276173,-0.02998651,-0.08893168,0.024142927,-0.0026694692,0.013267833,-0.060224038,-0.041197952,-0.013083666,-0.032559022,0.043140624,0.035684157,-0.072930336,0.056800045,0.12647466,-0.053425904,-0.057877216,0.030654745,-0.008236916,-0.035169322,-0.10133138,0.0509783,0.094398975,0.048387878,0.05084697,-0.0029473824,-0.021666037,-0.02896999,0.045933753,0.026062293,-0.022836642,0.027228648,0.059896052,-0.02136708,-0.06005681,0.033446405,0.1661833,-0.0054594628,0.13517843,0.060325872,0.03952192,-0.02940619,-0.07309715,-0.10625223,0.042838942,-0.09301659,-0.052901533,-0.008914737,-0.018714044,-0.051693268,-0.0439023,-0.09356609,-0.038027912,-0.135636,0.0053341766,0.037203487,0.008320735,0.09448803,-0.010272152,0.07384431,-0.0062859957,0.07265158,0.02460759,-1.9044652e-08,-0.04491935,0.02431846,0.057784896,-0.024428157,-0.06551002,-0.008595209,0.1424307,0.046081714,-0.07299528,-0.05006278,0.015681736,0.042708393,0.12146516,-0.07039245,0.11363907,-0.011537548,-0.031428274,0.049826726,-0.06958879,-0.04129041,0.007523217,-0.056495786,-0.012990289,-0.07040598,0.007820702,-0.08444087,0.016775865,0.011907328,0.039404877,0.008019067,-0.008558427,0.0126815075,0.0035862124,-0.057632156,0.044207282,0.048719145,-0.022171132,-0.017270897,-0.017981531,0.00077601266,0.0054422626,-0.019759735,-0.081091546,0.03766262,-0.025469882,-0.01571212,-0.037640415,-0.00072858325,-0.015196929,0.019103717,0.06778096,0.013618372,0.038522787,-0.010445612,0.009240287,0.0064135203,-0.05363653,0.056784634,0.06834839,-0.064797126,0.03348907,0.03915087,0.08265099,-0.048769295 +1.1.1.8,"Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).",384,1.0,-0.03371426,-0.05915352,-0.06768557,0.011002208,0.10887351,-0.020903261,0.013446705,0.037912454,0.0521117,-0.047371738,0.018100405,0.072573215,-0.08480916,0.06538563,0.036018398,0.026050057,0.05864905,-0.036554467,0.014619695,-0.060081154,0.08054566,0.019045303,-0.020087196,0.011030059,-0.03568851,0.049777046,-0.018271873,0.061514113,0.043429088,-0.016434725,-0.025024114,-0.015224878,-0.055997815,-0.027478674,-0.005059816,0.06890477,-0.10667204,0.0465656,0.0003215488,0.038852576,0.094227925,-0.0857166,-7.239738e-05,-0.05197662,-0.00026109247,-0.03281882,-0.03469729,0.051868632,-0.021414064,-0.01000115,-0.0055037984,-0.030454323,-0.026515884,0.0115680965,0.017381117,-0.028202794,-0.12677589,0.06708646,0.008767715,-0.052250843,-0.029138941,0.04296809,-0.05691921,0.05541345,-0.033166524,-0.03912746,0.07966624,-0.03845278,0.0377638,-0.043788414,-0.022959055,-0.040946443,0.045337785,-0.022363774,0.0029308978,0.07201117,-0.065943375,-0.06607836,0.05144582,-0.06298227,0.04405946,0.024184259,0.03241892,0.051168635,0.030220812,0.059455,-0.027270585,-0.03803751,-0.007054016,-0.014249994,0.040685702,0.010526501,0.028066073,0.039465588,-0.038555715,0.040645838,-0.018889407,0.041387014,-0.04818423,-0.0047104536,-0.060375635,0.0477222,-0.09330056,-0.057921547,-0.06781653,0.03564926,0.03854301,0.0153839635,-0.0014636477,-0.017769743,-0.054034382,0.0055691735,0.069197595,0.0023454546,-0.07873615,0.021906609,0.064780205,0.024178669,-0.060153026,-0.037582416,0.005947669,-0.066917315,-0.017830415,-0.0026728818,-0.05059284,0.08705132,-0.02633334,-2.6473767e-34,0.055783212,0.06427876,0.008817089,-0.011316383,0.038140617,0.031059682,-0.08067898,-0.023572745,-0.03870996,0.0435704,0.037363056,0.0052557746,-0.011569796,0.05720948,-0.049427792,-0.022416528,0.01701503,0.042021908,0.09846411,-0.09107837,0.0061327773,0.09366895,-0.050863557,-0.006388684,-0.014574367,0.01870869,-0.04458511,0.021758737,-0.016767949,-0.026824137,0.05432054,-0.077386424,-0.04607907,0.021689806,-0.009028193,-0.0064530685,-0.07955846,-0.06961721,-0.06555144,-0.025554365,-0.026457025,0.02088109,-0.031815995,-0.0037545983,-0.015062874,-0.079234995,-0.08755606,0.10013472,0.014919352,0.045691676,0.035277866,-0.0061650705,0.065729424,-0.02114621,-0.072653204,0.03895854,0.026759027,-0.065695606,0.02229629,-0.0025240814,-0.038808558,0.034115776,-0.042150952,-0.080061026,0.042924333,-0.042439215,-0.061998256,0.01939638,0.015099787,0.02530575,-0.03855573,0.02299598,0.07523584,-0.009235153,0.023638206,-0.0183903,0.024105912,0.017652217,0.0035147432,0.027722243,-0.029654957,-0.08110177,0.09076132,0.05516545,-0.107666425,-0.009155887,-0.010193798,-0.12480668,0.010535064,0.01421602,0.06093321,-0.076221414,-0.025968019,0.015925856,0.006580687,-8.2474465e-34,-0.009124728,-0.033702426,0.056429897,0.015814038,0.004535631,0.010024748,0.042663973,-0.07375147,0.047227312,-0.049775377,0.0788495,-0.0014945114,-0.016986655,-0.013779074,-0.020904427,0.080602676,-0.013598597,0.033837814,-0.005818668,-8.886471e-05,-0.014876383,0.10012337,0.025110306,0.1293387,0.052569076,0.027479272,0.065422945,-0.037382953,-0.0041207983,0.087933265,0.07396692,0.057809632,-0.06948997,-0.09004368,-0.06276758,0.027026843,-0.05006915,-0.015417584,-0.036170237,-0.06637135,0.012881406,-0.025358362,0.04919245,0.04595981,0.0045500086,0.09080855,0.06631238,-0.022603657,-0.051205307,0.0067552654,0.005877899,0.041348472,-0.071937524,0.11111739,0.11313407,0.055410985,0.035078544,-0.036006838,-0.008569932,-0.024885356,0.028309714,0.019673547,-0.054487437,0.012379496,0.07084707,0.026310172,-0.00076775486,-0.0030397377,0.123402774,0.018709015,0.09092392,0.009061804,0.055936575,0.022853637,-0.09542502,-0.06245491,0.009406497,-0.07763487,-0.048877977,0.0018613243,-0.008256655,-0.01764754,-0.053422812,-0.08311532,-0.0025615776,-0.055647306,-0.042279813,0.1140482,0.019180393,0.081260145,-0.029542038,0.03509456,-0.051127367,0.041258525,0.03470804,-2.7438814e-08,-0.01893465,-0.027289959,0.081324026,-0.049910862,-0.10810987,-0.020956255,0.15837295,0.077140875,-0.06125733,-0.044616804,-0.017506277,0.051994942,0.083501354,-0.0884834,0.101847716,0.010334097,-0.02339493,0.050918505,-0.058055885,-0.10811918,-0.039716057,-0.053399347,-0.04353353,-9.810256e-07,0.009116908,-0.11074477,0.049160827,0.020609643,0.046376534,0.019200362,0.009225866,0.0036171298,0.0017928925,-0.07770668,0.03441975,0.11670328,-0.024985353,0.0020269593,-0.018120315,0.032314517,-0.04033312,-0.02671982,-0.050973564,0.0416276,-0.02547341,-0.017327592,0.010204572,0.059706505,-0.017171644,0.0058819535,0.07726045,-0.00082281383,-0.0024988342,-0.051636253,-0.08829325,-0.047346257,0.004898696,0.047935423,0.10472972,-0.06196989,-0.020609144,-0.023248024,0.11133694,-0.041232932 +1.1.1.9,Also acts as an L-erythrulose reductase.,384,0.99999994,-0.053467013,-0.090934716,-0.1453294,0.049740188,0.06933596,0.056153785,0.00051208003,0.05170262,0.036045097,-0.032229904,0.019222066,0.02901191,-0.05259631,0.024518715,-0.008172657,0.0042437273,-0.0691313,0.01958484,-0.06346561,-0.060044013,0.039349277,-0.00021430172,0.009434908,-0.03280999,0.12648629,-0.09202971,0.02348053,-0.045316167,-0.06270158,-0.086410515,-0.0048385337,-0.039715324,0.048229918,-0.02167899,0.015479338,0.07702375,-0.09546921,-0.048017275,0.005157705,-0.024829594,0.05376755,-0.07415895,-0.009241373,-0.001242898,-0.07635208,0.035224464,-0.017972548,0.035646606,0.012328415,0.037178643,-0.0067906836,-0.012425628,-0.06876972,0.043179847,0.0036811403,0.04257521,-0.05677119,0.02788927,0.0406466,0.053971887,-0.0072662076,0.024939265,-0.0075513734,-0.0049141403,0.019351287,-0.031714406,0.021614907,-0.08765838,-0.046770833,-0.028219808,0.044631306,-0.054734327,-0.08197562,0.07285628,0.029062048,-0.026195439,-0.040398322,0.044662014,0.0019255625,0.039138902,0.018172305,0.1001586,0.025149092,0.051319603,0.0313079,0.007301191,-0.07621507,0.011975325,-0.052931696,-0.020326916,-0.012626893,-0.062415905,-0.048824523,0.042266224,-0.023960358,0.01103432,0.016825331,0.0002485699,-0.007651134,-0.053751383,-0.009605295,0.07327515,0.00464157,-0.029705191,-0.05003622,-0.048970636,-0.010089652,0.0867866,-0.021410981,-0.098594025,0.08597697,-0.011101016,0.052414794,0.033697534,-0.03915186,0.048845902,0.012402043,-0.0629615,-0.11116567,0.029151032,0.07438353,0.0069268094,0.022769371,0.05087901,-0.0036506276,-0.028023915,-0.10791458,-2.003915e-34,0.03953867,0.012528512,-0.016496805,0.019530058,0.016931579,0.06857768,-0.055583343,-0.0196784,0.045698896,-0.013794381,-0.011317174,-0.061047144,0.055473465,0.030433891,-0.10740091,0.054169845,-0.024714401,-0.018914081,0.050287373,0.013306405,0.013788083,0.11415355,-0.01671006,-0.023072982,-0.04130494,0.030573383,-0.023089118,-0.006246429,0.06472703,0.0060786866,0.029038623,-0.062802635,-0.04658577,0.07238756,0.02537159,0.027167803,-0.07945907,-0.037754174,0.0094827805,0.050363593,0.0074149044,0.046715043,-0.055576324,0.0020491346,0.09834499,-0.075465135,-0.027188163,0.028142704,0.0029879825,0.04414043,0.03281956,-0.0056396695,0.10967487,-0.043393172,-0.03135482,0.013414314,-0.011942518,0.053880397,-0.022833161,0.06704185,0.079197556,0.093434975,-0.0524612,0.049045157,-0.00206707,0.038212966,-0.03175347,-0.09724332,-0.03197738,0.038067102,-0.01474282,-0.06152257,0.14306197,0.007776434,0.0046486566,-0.025427451,-0.055352263,0.019133344,0.020932136,-0.037112534,-0.023739278,-0.01874322,0.026361248,0.013534409,-0.023536729,-0.043136533,-0.009568814,-0.0956405,-0.03892025,-0.012060468,0.054497175,-0.06515514,-0.08613965,-0.024169188,0.029511625,-9.2706455e-34,0.08090753,-0.07767925,0.007239128,-0.035423495,0.04011313,-0.0055310065,0.04009829,-0.012645433,0.026915655,0.07914659,0.08596094,-0.009432666,-0.10312563,-0.0099067995,0.05770972,-0.008504289,0.041630782,0.055450644,-0.05490275,0.0028775097,-0.09126821,0.09616837,0.07462112,0.054533493,0.06753904,0.036030427,-0.049864892,0.018829206,0.014348715,-0.024653886,-0.049718462,0.0002588584,-0.07542999,-0.12078621,-0.033576705,0.05096337,-0.045319293,-0.021766154,-0.012222674,-0.060727227,0.06772313,-0.0052575488,0.09183948,0.033214998,0.08610563,-0.0014586913,-0.054433532,0.079615265,-0.0558821,-0.031804007,-0.021678595,0.012666387,-0.013613183,0.03170773,0.0026365812,0.01862444,0.0444289,0.04093949,-0.014045318,0.0012760093,-0.036333226,-0.038293965,0.003968688,0.03189919,0.030602554,0.010278691,0.0015325211,0.040801834,0.055200987,0.07673461,0.14397132,-0.0033525452,-0.009336263,0.06817905,-0.090179056,-0.097502984,-0.04821494,-0.025382921,0.029676536,-0.03883202,-0.07261728,-0.063768856,-0.00078139454,-0.04834023,0.03752388,-0.11541466,-0.05412721,0.061568882,-0.00019757422,0.018270915,0.008584587,-0.106061846,-0.04787299,0.056375515,0.06947789,-1.9368736e-08,0.060994755,-0.006595761,-0.010101361,-0.09092173,0.044310007,-0.06270364,0.044934224,0.05861773,-0.0072231824,0.012280041,-0.016252711,0.038503606,0.06570998,-0.07881729,0.077720575,0.048447292,0.04191701,0.043287154,-0.024096968,0.026666837,0.02289927,-0.05231031,-0.077322245,0.06665358,-0.001360927,-0.073826484,-0.014567535,0.029851789,0.047006756,-0.048676476,0.081394404,0.010665524,0.04142277,-0.0048552123,-0.04852056,0.0072149164,0.0027534196,-0.0474464,-0.015645504,-0.018389784,-0.07232434,0.034147024,0.016036145,0.05274313,-0.015220813,-0.009488864,0.013568117,-0.058574937,0.040110666,-0.029574813,0.009935957,-0.04147219,-0.012194532,-0.0473263,-0.12506463,0.039179955,0.021099444,0.015681248,0.065423846,-0.018007956,0.03278863,0.04826213,0.18350859,0.022430697 +1.1.1.14,"This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+.",384,1.0,-0.063880555,-0.088147886,-0.07524017,-0.053775962,0.04002587,0.032456744,-0.07486014,0.02949948,0.054994706,0.040212832,-0.013210875,0.016164696,-0.113900214,0.10121727,-0.067609675,0.019643592,-0.0032900267,-0.019186335,0.01909459,0.016328653,0.11789123,0.04482385,0.029121894,-0.037259173,0.08062654,0.016734853,0.05104839,-0.030202948,-0.028635481,-0.08388867,-0.01728976,-0.03131482,0.04225237,-0.061008252,-0.0069642765,0.035516225,-0.052892465,-0.037186567,0.046857048,-0.032836497,0.0053977836,-0.030284557,-0.038931232,0.019966329,-0.055877402,-0.042077344,-0.05452111,0.068241134,0.03228673,-0.015054841,-0.02971012,-0.06933073,0.017740285,0.019378956,0.05408785,-0.016245887,0.02317555,-0.060384817,-0.011426604,-0.0523679,0.05589234,0.006661464,0.044407643,0.031364966,0.02840675,-0.050677314,0.023248864,0.011541988,-0.013547864,-0.09288687,-0.09239801,-0.07450937,0.04678667,0.09490903,0.0039012444,-0.015052936,0.010296954,-0.030948365,0.0755903,-0.02900727,0.056547273,0.051736407,-0.00646063,0.07589535,0.04430799,-0.01896509,-0.0026756586,0.060684573,0.010614348,-0.026000287,-0.017042933,-0.04615786,-0.06494253,-0.046491373,-0.09918834,-0.012965259,0.049694356,-0.046460878,0.013841304,-0.05714959,0.02253671,0.06830152,0.02527224,-0.08379439,-0.067884356,0.01557606,-0.04714847,0.10257015,-0.0017919926,-0.027700463,-0.0010495445,0.027916238,-0.0013557593,-0.0033239408,-0.030608138,0.055777647,0.04689736,-0.042419534,-0.09046285,-0.055557203,-0.016824966,-0.052314237,0.08363423,0.062685184,0.00083992875,0.077196896,-0.06100153,-1.07966015e-33,0.07943225,-0.04875001,-0.07193276,-0.01599204,0.0822104,-0.016174454,-0.04663299,0.024267118,-0.030578328,-0.0049079983,-0.06031032,-0.067719094,0.011196286,0.040520318,-0.0077826506,0.11083115,-0.012650008,-0.040043455,-0.0023513187,0.013439242,-0.02435914,0.06418625,-0.021625213,0.009572512,0.04237252,0.08581343,-0.016997756,0.05740659,0.033238612,-0.013805143,0.04227538,-0.09390683,-0.08153821,0.043958038,0.08941809,0.096290015,-0.05425919,-0.026995603,-0.004584174,0.023497522,0.010609731,0.028930184,0.037608784,-0.046714667,0.027248936,-0.01852736,-0.055941347,0.057315726,0.012445322,0.06584437,0.061296057,-0.06313371,0.050267354,-0.011645146,-0.052117817,0.10232283,-0.09802801,0.014555799,0.029900959,0.08221836,-0.016499853,0.026544655,-0.06835148,0.05970524,-0.02072313,0.041114572,-0.07181486,-0.06997229,0.011653567,0.08105891,-0.018625092,-0.013120605,0.033561666,0.03668311,-0.016757032,-0.067697264,0.027503317,0.02312273,0.031692147,0.03557664,-0.01837038,-0.063093506,-0.028963512,-0.034448527,-0.04428042,0.07056553,-0.015450499,-0.06945178,-0.0242556,0.031042684,0.0041077747,-0.023140509,-0.010632762,0.01855135,0.022744367,-2.5966005e-33,0.052686334,-0.10121178,0.08991357,-0.09180805,-0.036131535,0.12408346,-0.0037013683,-0.08193194,-0.028987305,-0.04700354,0.050925504,0.0628448,-0.008875359,-0.010111757,0.03025412,0.01493736,-0.046019536,0.025781933,-0.02822647,0.018766899,-0.016861346,0.11541001,0.0638671,-0.02239213,0.07977564,-0.059508808,-0.03351432,0.062239666,0.0231924,-0.009884494,0.034112155,0.036947396,-0.04696684,-0.09170557,-0.01888984,0.00085232,-0.06731017,-0.008507285,-0.026189692,0.05749608,-0.0036292663,0.06264545,-0.04952925,0.026413431,0.047706883,0.042299967,-0.109198466,-0.05331304,0.03690288,-0.054738287,0.041390788,0.012676281,0.0073203957,0.032772485,0.054477904,0.06832322,-0.019904304,0.06625277,0.018541286,0.0062133055,-0.050383985,-0.060647424,0.041840475,-0.020889755,0.084799536,-0.00033857033,-0.010956316,0.024481017,-0.02943747,-0.028681101,0.10239738,-0.047330514,-0.03540289,0.08880275,-0.060219165,-0.084232345,-0.11769644,-0.011716712,0.006018691,-0.007000359,0.04966947,0.034000017,-0.018817812,-0.03239334,-0.02811464,-0.07380779,0.05765943,0.10594669,-0.0047711534,0.042633925,-0.021805802,0.07535043,-0.09118184,-0.018084077,0.04170147,-3.851185e-08,0.06453534,0.012615998,0.0147126,-0.075763434,-0.011555817,0.04317488,0.013325785,-0.03380953,0.027665941,0.01318587,-0.042906772,0.17212342,-0.015657166,0.026445132,0.018312858,-0.017902547,-0.05125241,0.0069417935,-0.03668728,7.382542e-05,-0.04957345,0.016761817,-0.073096395,0.005258572,-0.025108607,-0.07548211,0.033922464,0.016199643,0.05500128,-0.06554061,-0.05867286,0.09349335,0.03214956,-0.055276316,-0.047380585,0.058293033,-0.045271497,-0.045459066,-0.014212604,0.07528508,-0.018443592,-0.0771491,-0.0045071393,-0.005495001,-0.03214751,0.033765808,0.014121973,-0.01273921,-0.036896467,0.07416244,0.024806978,-0.011294946,0.014889836,-0.09037253,-0.09316467,0.030022811,-0.040253874,-0.07310604,0.0077814423,-0.05390498,0.07024202,-0.038424805,0.11990626,-0.022749914 +1.1.1.15,Also converts xylitol into L-xylulose and L-glucitol into L-fructose.,384,0.99999994,-0.008549941,-0.08223631,-0.0638886,0.05205941,0.05179407,0.033570115,-0.062736675,0.03412566,0.0555002,-0.046847712,0.054775458,0.0005425686,-0.052268296,-0.00067837746,0.014535451,0.0077402787,-0.035192546,0.028641842,-0.11830429,-0.014060115,0.12697843,-0.05369245,-0.011470863,0.006189387,0.09514877,-0.0056444653,-0.020147787,-0.08576841,-0.0032105474,-0.07002616,0.019951513,0.004503435,0.038098395,-0.082146384,0.05013399,0.030319624,0.0014132159,-0.02768608,0.061856452,-0.04462078,-0.03428693,-0.13286738,0.039466474,-0.021521224,-0.09078335,-0.04286145,-0.018259779,0.040857494,-0.014357744,0.03777067,-0.026494248,-0.008067784,-0.06806651,0.024987593,0.023037769,0.086496204,-0.03587497,-0.015866091,-0.01639309,0.06260046,-0.07052896,0.1083215,-0.06547593,0.041260026,-0.021963974,-0.08584069,-0.024497524,-0.04447674,-0.0072136093,0.001891884,-0.055795494,-0.06292709,0.013275478,0.021454062,0.04950688,-0.029668689,0.034242667,0.022009546,0.05529398,0.06343902,0.07982343,0.05699334,-0.023179842,0.034751132,0.0036773728,-0.026356049,-0.008756867,-0.0038676504,-0.021943452,-0.059598614,-0.016786512,-0.06113661,-0.012100544,-0.0067777396,-0.013895917,0.030756285,0.047057547,-0.050042458,0.050482374,-0.029834768,-0.011553891,-0.015462241,0.054849707,-0.08388096,-0.10015439,-0.01604974,-0.017325258,0.12162222,0.0073359734,-0.08267337,0.024244627,-0.02554851,0.026448835,0.024775792,-0.079967126,0.038903467,0.03680811,-0.07080206,-0.031520803,-0.030771397,0.059501488,-0.01988893,0.04137425,0.09709003,-0.05685462,0.032556985,-0.0022756606,2.4476413e-33,0.01792335,0.040499546,-0.02695783,-0.03992287,0.0030130583,-0.0003670154,-0.032747213,0.023742354,0.020627348,0.04520455,-0.006476955,-0.026736217,0.018957922,0.038427576,-0.07519515,-0.008717207,-0.06415916,-0.018554423,0.04029496,0.06283464,0.016304871,0.096976504,0.015627645,0.035523705,-0.016228138,0.053344905,0.027386988,-0.020086521,-0.0032786422,-0.007953027,0.036056932,0.0036181482,-0.04386864,0.058083568,0.02421015,0.13956943,-0.06443453,-0.089247175,0.04374637,0.061509654,0.034218952,-0.0037383349,-0.028232846,-0.009185032,0.027498253,0.009299569,-0.08615324,0.0009132209,0.021925736,0.012359629,0.08001202,0.004750926,-0.03998583,0.080838464,-0.029072039,0.037258837,-0.024400963,0.017448995,0.009518059,0.03544093,-0.027513161,0.048753235,-0.012857832,-0.05024638,0.0032516003,-0.026445093,0.021682024,-0.060801283,-0.024974488,0.036874883,-0.09771094,-0.030130016,0.08359784,0.04094206,0.08017188,-0.050943058,-0.08570717,0.03857204,0.07798754,-0.009708161,0.06846477,-0.01249252,0.041072708,-0.03265501,-0.062471904,-0.053055882,-0.0547702,-0.0596268,0.0027494708,0.0304738,-0.05870017,-0.091933645,0.053477615,0.060394097,-0.016893776,-4.2725906e-33,0.03977055,-0.09602206,0.038174666,0.022946632,0.0040352535,-0.028228952,0.002974462,-0.1164726,0.02877916,0.019401025,0.076055676,0.024177535,-0.044776388,0.006573611,0.01573559,0.0030989046,0.019638378,-0.00902725,-0.05317683,0.028722197,-0.011206496,0.0684675,0.06500971,0.033967823,0.109720275,-0.0031468752,0.044911332,0.0021802112,0.0600029,0.021150507,-0.016393881,-0.06606872,0.016126227,-0.13454111,-0.069841534,-0.0045607765,-0.04033782,0.043851018,-0.006619543,0.012767126,0.0121382885,0.04328712,0.09008647,-0.029695263,0.010297681,0.0596494,-0.070072636,-0.09248456,-0.0044793533,0.012147153,0.033282008,0.026967376,-0.096519396,-0.0073961555,-0.061933253,0.07939655,0.044221714,-0.06458358,0.009777233,-0.050388645,-0.118882194,-0.06461629,0.045665924,-0.04228044,0.08667107,0.014322875,-0.0058390195,0.036910806,0.0052564256,0.035474725,0.13324316,-0.031002253,0.04731922,0.08144877,0.025396544,-0.105697796,-0.062587045,-0.09558808,-0.028832173,-0.0745404,0.042901393,-0.05188757,0.025266843,-0.08040493,0.03337113,-0.0907524,-0.0050241104,0.07414769,0.03282061,0.027165098,-0.039131425,0.007156948,0.025148384,-0.024265338,0.17484316,-2.4552804e-08,-0.051441703,-0.011572484,-0.07967005,0.0040092864,0.009778402,0.01967516,-0.019686837,0.008272408,0.015880898,-0.026465818,-0.06406269,0.1433083,-0.0069051823,-0.013272265,0.013942257,0.0032326824,-0.006851694,0.025510676,0.020989899,-0.007343069,-0.06542475,0.017678225,-0.033214394,-0.0012483214,0.0054574325,-0.06229995,0.014563198,0.068925336,0.046713024,-0.014145975,-0.04293546,0.0622639,0.03972276,-0.0064224396,-0.031652983,0.054396845,-0.036398243,-0.07004891,-0.029234832,0.0087011475,-0.024071913,0.06490667,-0.016890692,-0.0001954507,-0.011777967,-0.066847794,0.048539612,-0.0010784797,0.010740278,0.05820443,0.023122516,-0.019168243,-0.050058585,-0.09294197,-0.02308665,0.003276834,-0.039032057,0.008353798,0.06861114,-0.0070138755,0.018586986,0.031072067,0.19413823,-0.023661086 +1.1.1.16,Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.,384,1.0,-0.035204373,-0.10010367,-0.09580596,0.021833917,0.04000766,0.02271856,-0.06769416,0.03266961,0.032663386,-0.0023965528,-0.014514578,-0.008925037,-0.061563537,-0.088244855,-0.037176672,0.0855085,-0.04584437,0.035918273,-0.050997343,-0.0014960413,0.0909202,-0.0035459853,-0.0034868591,-0.041109655,0.08177912,0.037577573,-0.035064936,0.016202044,-0.03501955,-0.1070243,0.04980503,0.05081205,0.07122227,-0.043184597,0.018354893,0.048244942,-0.021760363,0.0029301671,0.07901223,-0.045328304,0.042082164,-0.027255286,0.05947014,0.032188125,-0.04804337,0.026612522,-0.068375014,0.081866056,0.008219518,-0.0007061155,-0.026286224,-0.054387975,-0.04016313,0.06132919,0.030593313,0.10444113,-0.0017112545,-0.06319217,0.041336432,0.04281284,0.02271815,0.021949336,-0.012070729,0.062286414,0.027330065,-0.03213887,0.011017088,-0.06886647,-0.038932092,-0.019488847,-0.106756896,-0.09132589,0.02719228,0.06576527,0.098915115,-0.0046234815,-0.031011421,0.0008991523,0.058949936,-0.023144897,0.04717254,0.07706897,0.027373375,0.084301226,-0.03279228,-0.05551479,0.052563753,-0.046162523,0.059152946,0.010901042,0.009716894,-0.050767314,-0.013417298,-0.09235327,-0.045487873,0.032683197,0.055843912,-0.047522318,0.047969863,0.005741995,0.01752251,0.039229043,0.037981085,-0.11976149,-0.08285311,-0.029474027,-0.0077019637,0.1402863,0.002326775,-0.0013370134,0.0052085575,0.0077903583,0.063125804,-0.050295386,-0.049089927,-0.03304692,0.024389617,-0.07782707,-0.036712255,-0.07603326,-0.058105387,0.012526065,0.062074374,0.0693472,0.047555543,0.021948345,-0.06776746,3.684744e-33,0.031331457,-0.037819665,-0.033239096,-0.042097587,0.053422622,-0.039395154,-0.083966345,-0.007992181,0.019420443,0.0042469827,-0.075503334,-0.037098065,-0.0016596944,-0.012270217,0.014943498,0.032379933,-0.0033929334,0.00813291,0.019885419,-0.021561028,-0.045534458,0.031029597,-0.047802046,0.04652929,0.020141855,0.1149397,0.084182926,0.000951863,0.007993937,-0.0029509608,-0.022398856,0.03341542,-0.07090979,-0.012348664,0.054657787,0.055119265,-0.034106426,-0.035951942,-0.00112834,0.07515885,0.07300669,0.08633724,0.011807449,0.033392336,0.052994598,-0.0031704789,-0.049866043,0.10083423,0.06581684,0.07565928,0.051101368,-0.0788495,0.08224052,0.041406576,-0.06315773,0.060245056,-0.09047102,0.04745484,0.042420626,0.012893803,-0.03762175,0.045217577,-0.031907197,0.004598442,-0.049790666,0.012191819,-0.05128587,-0.040592078,0.014557229,0.03316392,-0.065124065,-0.0275416,0.026191965,0.07433881,-0.017240513,-0.015791357,-0.034093123,-0.061959483,0.031133216,-0.042063743,-0.0076945308,0.009872154,-0.003946211,-0.048269235,-0.048051454,-0.05765056,-0.06610631,-0.11451151,-0.047711603,0.007014146,0.019436127,-0.048886415,-0.07600798,0.072406225,0.031118905,-4.510779e-33,0.054250475,-0.12591322,0.09479686,-0.04403388,-0.0053470996,0.014449099,-0.0028940875,-0.053134862,0.018909141,-0.02086338,0.060108185,0.047546692,0.034779552,-0.053363264,0.003260196,-0.025617875,0.02938977,0.053111125,-0.06265501,-0.004102644,0.01277023,0.1122173,0.047388572,-0.02799597,0.045404103,0.0047062417,-0.0116132945,0.12904714,0.065270536,0.025745554,0.06998716,-0.016008032,-0.02005495,-0.047799896,-0.09908751,0.018756691,-0.028210854,0.02093394,-0.06087078,0.012372069,0.011359534,0.035222743,-0.0037562675,-0.012566941,0.07202343,0.041510306,-0.0689829,-0.030421745,0.05746414,-0.054959055,0.04487216,-0.021582836,-0.034639128,0.04882764,0.0027959936,0.059914142,0.048763834,-0.05673748,-0.07211273,-0.041761287,-0.08203068,-0.014196043,0.11094686,-0.033619393,0.07970668,0.045876972,0.021649664,0.096086785,-0.02402584,-0.010243696,0.10652135,0.021388007,-0.044312578,0.0147463195,0.04374033,-0.033332225,-0.06352185,-0.032824703,-0.056269,-0.044207774,-0.02740835,-0.000999343,0.01638428,0.017656729,-0.07637505,-0.04501608,0.06292325,0.05305992,-0.033032544,0.07422282,-0.053278986,0.022458315,-0.018800166,0.042841844,0.051065564,-3.4065106e-08,-0.012449909,0.03087364,0.0012614045,0.001036004,0.020136049,0.0616387,-0.07182256,0.049250644,0.0045329626,-0.05874172,-0.08570261,0.12729731,-0.031996578,0.021862576,0.058767103,0.014380847,-0.02694357,-0.021180334,-0.036734223,-0.011527914,-0.0742875,-0.04522157,-0.014702624,0.030581236,-0.03772493,-0.07111169,0.021786408,0.0076653943,0.0036976421,0.0067212777,-0.009201316,0.078109376,-0.01896065,-0.03200552,-0.05181624,0.03438556,-0.047742117,-0.11204788,-0.0064438516,0.041131776,0.0079120705,-0.014628562,-0.07876753,0.018982084,-0.085799135,-0.014151582,0.004287155,0.030152557,-0.032284927,0.03491368,0.054713573,0.007817698,-0.092454724,-0.046833064,-0.06732784,-0.032162674,-0.0015085111,-0.052502003,0.047844876,-0.021155633,0.050553866,-0.021200992,0.16127835,-0.022082735 +1.1.1.19,Also reduces D-galacturonate. May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)].,384,1.0,-0.023757529,-0.025551293,-0.0045640683,0.0012891457,0.024816332,0.000595094,-0.042612582,0.058793236,0.043913443,0.0019029509,0.022909079,0.024557224,-0.097593725,0.036001883,-0.044511616,0.02217435,0.014673505,0.027822234,0.030908816,-0.0017471176,0.06252465,0.021175856,0.0804381,0.03420209,0.08120984,0.01210641,0.037326377,0.02752495,-0.02311501,-0.09565071,0.0555709,0.003097809,0.031439617,-0.046217892,-0.06491837,0.034451894,-0.03608202,-0.014795502,-0.0069562835,0.025796356,0.044184625,0.010909292,0.00522701,0.0070447167,-0.026587559,0.016508536,-0.07674248,0.09739203,-0.015963046,-0.017737793,0.022282248,-0.058845326,0.018303227,-0.041385565,0.1022766,0.06774772,-0.06506566,-0.009937617,-0.016374903,0.0053422716,0.018512553,0.04530143,0.027156089,0.040302113,0.023651851,-0.06614447,0.066111594,-0.08077947,0.0012651792,-0.0321921,-0.031751186,-0.086086184,0.026304675,0.022858549,0.013393337,0.03845067,-0.042056605,-0.07231815,0.06642632,-0.017729636,0.03847554,0.04546272,-0.021036612,0.050255064,0.043055277,-0.028609654,0.080309555,-0.08352482,-0.10315578,-0.009284467,0.041704275,-0.08149723,-0.063723855,-0.003214547,-0.122064956,0.0032385087,0.035730716,0.030294595,-0.03284994,-0.040304344,-0.004893267,0.09522525,-0.0393446,-0.060874294,-0.044482447,0.015505293,0.042372167,0.05745359,-0.017725449,-0.027689546,0.036880314,-0.05070592,-0.007972582,0.049666815,-0.05611078,0.11480071,0.030968186,-0.005968919,-0.02179897,-0.005466512,-0.0048814323,-0.06283211,0.038179185,0.017316654,-0.031728774,0.048670065,-0.080724046,-8.3221614e-35,0.027503796,-0.011583982,-0.057573445,-0.04643999,0.05140224,-0.004479843,-0.11248208,-0.0032497153,0.025921213,-0.059991796,-0.0957631,-0.021559093,0.058609888,0.021453513,-0.02062117,-0.018078841,-0.027812904,-0.019979702,0.0088252155,-0.067484744,0.00028346645,0.02249289,-0.041540433,0.017043633,0.044658814,-0.0043581952,0.009573818,0.052935623,0.08416021,0.014406526,-0.037589047,-0.037771933,-0.062771805,0.0037166877,-0.01955074,0.098640226,-0.00983524,-0.08528696,0.014093696,-0.0025523917,-0.028328203,0.047837853,0.007337835,-0.043287545,0.0029692147,-0.067051105,-0.03374304,0.037882216,0.02757972,0.0040138816,0.056842696,-0.037615098,0.068555295,-0.07183382,-0.009522091,0.051924855,-0.054059397,0.011823385,0.036809694,0.079892084,-0.02458075,0.039042246,-0.05600632,0.035974286,0.0029716266,0.025710037,-0.05211533,-0.10039036,-0.04679924,-0.05589853,-0.04856268,-0.028889382,0.12094413,-0.027475122,-0.041221112,-0.023238897,0.023456136,0.029777475,0.008024335,-0.02776416,-0.04490508,0.014257738,-0.010792623,0.01502008,0.06920787,0.028715312,-0.008089682,-0.034389462,0.0401546,0.040775564,0.0031626527,-0.016496422,-0.048360568,-0.014091627,0.016331984,-1.3603872e-33,-0.018604701,-0.08463311,0.06359886,-0.0026537906,0.009325641,0.15762758,0.07243703,-0.020719673,0.004977713,-0.11997903,0.08292783,0.020511653,-0.06658398,-0.09532723,0.049010057,-0.0264496,-0.07523633,0.047293857,-0.08956593,0.061996218,0.056077607,0.15380064,0.021786947,0.012702916,0.037425812,-0.029865226,-0.03932439,0.025560254,0.032955717,0.023870714,0.03043022,0.030166317,-0.10923675,-0.06389835,-0.01844175,0.049423266,-0.052349743,-0.002176971,-0.07348751,0.03651119,-0.04169192,0.040657755,0.01772945,0.02368529,0.12326529,0.070480525,-0.03971592,-0.035621885,0.07005412,-0.009513103,0.0044296756,-0.01939724,-0.04039607,0.098330535,0.009312025,0.0032257691,0.06988947,0.02305419,0.00038249037,0.010348521,-0.06171722,-0.0048056096,0.07870493,-0.067885235,0.05944954,-0.028685901,-0.029751256,0.121345975,0.051352013,-0.05594679,0.108190574,-0.007152288,-0.011030624,0.04071902,-0.040243555,-0.04229459,-0.09743266,-0.0006386255,-0.012409405,-0.009445411,0.040914673,0.05896753,-0.051122837,-0.008023073,0.0028940218,0.0005988907,0.048488457,0.101013,-0.05443048,0.054027654,-0.04257687,-0.0068911877,-0.07364112,0.02603683,0.02189869,-2.687475e-08,0.06537965,0.004587044,0.046080116,-0.023656957,0.013897366,-0.06884598,-0.008182294,0.044091478,-0.021674676,-0.08978873,-0.0312846,0.1561907,0.024572,0.059276383,0.030003048,0.011701229,-0.010120876,0.054532435,-0.024021711,-0.020663053,-0.059058554,-0.03656743,-0.06899622,0.00480098,-0.039573062,-0.050413493,0.07544856,0.06658632,0.034523632,-0.12121662,0.01395461,0.058741167,0.05625317,0.00039551224,-0.029509658,0.04321581,-0.025199484,0.032459125,-0.04858771,0.10713974,-0.038861226,-0.13067651,0.025968315,0.030275477,-0.033624962,-0.003325533,0.066662684,0.040306423,-0.076379895,0.03382381,-0.0068657487,0.010303011,-0.016957184,-0.08698052,-0.099650815,-0.0012634222,-0.045633536,-0.06379714,0.026789816,-0.09252649,0.047833562,-0.055072863,0.10343059,0.033381805 +1.1.1.21,Has wide specificity.,384,1.0,0.085168354,-0.02397405,0.01817872,-0.044137616,0.066592626,0.008389937,0.022931533,0.02056348,-0.08237203,0.014690326,-0.0037837732,0.03097544,-0.06321586,0.037343424,0.06842985,-0.032852944,0.048919417,-0.062385116,-0.051462874,0.014867652,0.049172245,0.022402348,0.061073583,-0.0066544367,-0.03772183,-0.03336618,0.030538533,-0.019124897,0.015435309,-0.07621071,0.05583135,0.1016606,-0.02798542,0.009957958,-0.02027894,0.075666524,-0.06598804,0.082572825,0.044675764,-0.016782388,0.03433335,-0.019281186,0.036944054,0.06648235,0.058772586,-0.05482935,-0.035923157,-0.0005801172,0.0014158062,-0.0061152545,-0.023197548,-0.09283768,0.014304514,-0.014145454,0.029983476,-0.017416673,-0.020795949,0.03248321,0.03107121,0.019940494,0.02272323,-0.0003229031,-0.061144195,0.028740825,0.08085032,-0.022759322,-0.060429525,0.013176281,-0.06487177,-0.011696118,-0.04189232,0.019846391,0.025149755,0.102886155,0.043513928,-0.034641623,0.032599855,0.010390667,0.004879486,-0.03480486,-0.03283547,-0.005204231,0.026560947,-0.04728257,0.15124643,0.011942837,-0.014181599,-0.04451177,-0.07040108,0.027802648,-0.013828169,-0.09735256,0.043965347,-0.03401769,0.024463799,0.014346565,0.038371943,-0.018383147,-0.033985928,0.08764326,0.0036817782,0.029854609,-0.009717225,0.020642117,0.021120155,-0.038661435,0.017628634,0.048721302,0.0034481643,-0.09815589,-0.053690374,-0.0069796448,0.022751663,-0.05539629,0.007261593,-0.08454534,-0.049589723,0.007173615,0.0238386,-0.0041039567,-0.022131942,-0.006545341,-0.02647429,0.020857634,-0.0035642546,0.0020690463,-0.060889963,-4.2915084e-33,-0.04220818,-0.048731726,-0.0067831078,0.12924439,0.03097219,0.07070189,-0.031269792,0.008532969,0.022469077,0.085909165,0.043947905,0.07103837,-0.007887352,-0.0030725335,0.1331877,0.078743264,-0.053234037,0.092222236,0.049431086,-0.015072143,0.045100983,0.034910347,-0.035607394,-0.028252438,-0.024955235,-0.037727598,0.06376388,0.051457867,0.02449848,0.020759145,-0.09244469,-0.024481451,-0.018569157,0.008681813,0.07661582,0.057104237,-0.07223772,-0.10413699,0.004548951,0.022170944,-0.08054803,0.015279396,-0.052874647,0.030683627,0.043905195,0.057852667,0.016582485,-0.0045941505,-0.11417512,0.04661963,0.0013320702,0.046829306,-0.02949846,-0.03653951,0.085477665,0.0556603,0.004428386,0.045992915,0.03145689,0.012778092,0.002370514,0.046969812,-0.048334733,-0.0228532,-0.034023836,0.06341108,-0.023478761,0.04429547,0.017314231,0.08723968,-0.052987073,0.008190653,0.10961358,-0.05102068,-0.09011217,-0.051830765,0.02386759,0.048471957,0.07301235,-0.029665774,-0.119214274,0.011355469,0.046485875,-0.0179802,-0.07928734,0.013044695,0.040897857,-0.03188719,-0.002213872,-0.00027300132,-0.049297903,-0.01060664,-0.04564923,-0.021613011,-0.07327395,3.3980743e-33,-0.15535083,-0.07589098,-0.07285404,0.024011625,0.0718721,-0.04051366,-0.03338424,0.030936738,-0.008325059,-0.00032117116,0.068829745,0.0091547165,-0.036914837,0.03147178,-0.0044064233,0.024013089,0.04184248,0.09650332,0.027315255,0.053385608,0.039651547,0.03154335,-0.05476455,0.06468592,0.029757984,0.046055455,-0.14704809,-0.025707666,-0.109168135,-0.039579652,-0.015244999,-0.051476408,-0.10617423,0.026965851,-0.069323935,-0.056823883,-0.0075578745,-0.020326765,0.037855152,0.008093735,4.806684e-05,-0.08270844,-0.020911336,0.08876733,-0.019508587,0.02860297,0.01177523,-0.005904199,0.028570604,0.035407413,-0.04481299,-0.024632586,0.018316822,0.0002419779,-0.033335,0.029322764,-0.072423495,-0.045076706,-0.06561701,0.008860194,0.030610202,-0.013729936,-0.04292177,0.062344227,0.060009953,0.012874407,-0.042823832,-0.0815654,-0.016645722,0.01691059,0.02378303,-0.17514285,-0.10029835,0.0035207598,-0.12573543,0.07387012,0.064898275,-0.07913891,-0.02019494,0.066729546,-0.0041359034,-0.054461967,0.01217112,0.01277101,0.074526414,0.07872315,0.002864766,0.024783423,0.01992961,0.00940522,-0.013435551,-0.030801667,-0.04181979,-0.070170484,-0.036892265,-1.9459762e-08,-0.042924494,0.021219995,0.008699487,-0.0038572089,0.024793053,-0.030447373,0.05616839,-0.074199125,-0.01934405,0.13911536,0.0176842,0.047205083,-0.038495302,0.07293189,0.08775818,-0.019353444,-0.082393974,0.007772393,-0.088196546,0.120771594,-0.08156426,-0.011642302,0.026340364,-0.032410502,0.012458866,0.012934079,-0.07446064,0.03975111,0.039067786,0.041430313,0.029598799,0.03846333,-0.011610319,0.0004923485,0.0920869,0.028729564,0.02184463,-0.0031198799,0.047579136,0.029942041,-0.037921097,0.01565147,-0.00195894,0.08857677,0.014671359,-0.023929445,-0.016993472,0.009650956,-0.06388475,0.06904072,0.04295532,0.061353542,0.028092485,-0.0060404576,0.08384918,0.04777674,-0.037222814,-0.052665126,0.003522379,0.0154060135,0.08057246,0.0032071073,0.08233479,0.018784111 +1.1.1.22,Also acts on UDP-alpha-D-2-deoxyglucose.,384,1.0,-0.099972025,-0.06907629,0.03708416,-0.019289505,0.04119957,-0.06277531,0.01088003,0.0130772125,0.0065019364,0.042179525,0.04843722,0.04311103,-0.112304084,0.06096889,-0.029793689,0.03775873,-0.01004561,-0.008250756,0.0079679685,0.014563115,0.029817952,-0.015388736,-0.007374294,-0.021147847,0.04281662,0.049668137,0.07471907,0.019966409,0.022893805,-0.11578955,0.04475497,-0.018398864,-0.007363983,-0.018646857,0.04314444,0.081358545,-0.039292682,-0.0039818077,-0.037904184,-0.021502804,0.08448142,-0.03417941,0.011276018,0.057844955,-0.054377783,-0.029474525,-0.10519106,0.044495318,-0.009678215,0.021134382,0.016795982,-0.021498462,-0.03596599,0.08205094,0.0070898384,0.021331819,-0.07234328,0.03958963,-0.02069944,0.015714634,-0.019445358,0.019780245,-0.011035452,0.03795684,0.05709346,0.03411804,0.07344281,-0.054629255,-0.06678456,-0.0029589941,-0.021494584,-0.0069185146,-0.035774417,0.011317984,0.01551584,0.044911243,-0.0371556,-0.1185803,0.044419564,-0.029057253,0.036224682,-0.0039484445,0.047319766,0.06949628,0.0002309794,0.020720357,-0.047035508,-0.0982329,-0.07655645,0.014603951,-0.048647396,0.0384461,-0.011365208,0.052885264,-0.06257809,0.06176689,0.035052832,0.07364502,-0.01591934,-0.007622176,-0.0908997,0.04594868,-0.10417661,-0.12776047,-0.043754347,-0.053190313,-0.01696768,-0.042251594,-0.035538305,0.03460467,-0.018966522,-0.019034382,0.07108431,0.03932673,-0.010766914,0.06606741,0.018214637,0.045710117,-0.02579973,-0.11278175,0.022143431,-0.060486734,0.012734912,0.022123225,-0.06644167,0.031609047,0.023506954,-1.6631748e-33,0.070405945,-0.016207946,-0.0508548,0.04774347,0.002755751,-0.022308186,-0.08553738,-0.01014896,-0.077690706,0.034468297,-0.0945112,-0.051883396,0.056995668,0.09380598,-0.025557175,-0.027368888,0.05044094,0.011963378,-0.007950862,-0.0061101248,0.058767118,0.12217738,-0.016634386,-0.018011052,0.026445717,0.05806819,-0.09512718,0.049296893,0.09868876,0.0039018488,-0.0012185528,-0.031355288,-0.11074686,0.061212983,0.022642018,0.050785687,-0.1232413,-0.030126005,-0.049181886,0.005940003,-0.002673397,-0.039338592,-0.08645714,-0.055665858,0.05000828,-0.02038935,-0.020209802,0.0024231563,0.00045763774,0.00016233923,0.042319663,0.012338677,0.028756073,-0.022034789,0.03375676,-0.03872153,0.045572013,-0.030704528,0.034248132,0.11025609,0.017503915,0.08289139,-0.024797942,-0.038959462,-0.01119686,-0.011380609,-0.048517648,-0.049150135,-0.021382192,0.01180206,-0.019055394,0.025142271,0.115063734,-0.008201538,0.00074119755,-0.036958516,0.001799045,0.005740803,0.064807005,-0.00043545532,-0.07060211,-0.09332926,0.011842735,-0.023573771,-0.025128888,-0.032937713,-0.05386556,-0.055928748,-0.035148524,0.024421308,-0.014396597,-0.0284887,-0.07213998,-0.02527324,0.030883905,-1.4959535e-33,-0.020551395,-0.06434932,-0.04409048,0.0127027705,-0.05271502,0.05380264,0.04918138,0.041096587,0.10182831,-0.0096841315,0.08060706,0.018471757,-0.079488985,-0.0062767193,0.10295549,0.005423009,-0.02789257,0.04217634,-0.035768375,-0.018581824,0.0077633737,0.15490824,-0.01384335,0.12447174,0.08191648,-0.0010105476,0.030097162,0.021380614,0.04429732,0.031524684,0.015854245,0.028803945,-0.056815885,-0.032370135,-0.016606053,0.06584091,0.03424943,-0.003945575,-0.105296,-0.056228608,-0.00036651388,0.0012945044,-0.022519045,0.10777233,0.09470163,0.06266457,-0.026471766,-0.004576454,-0.05847286,0.055160493,0.027231073,-0.0136530725,-0.004973052,0.04765669,-0.010054792,0.0917277,0.031545088,-0.02770316,0.009713212,0.0059736497,0.041880786,-0.077813976,-0.014187686,-0.031250097,0.045345344,0.02001726,0.0033919516,0.03403741,0.045556463,-0.017929504,0.07497524,0.007825917,-0.059687164,0.020015968,-0.04229065,-0.0604055,-0.07177902,-0.028097553,0.05237957,-0.01685499,-0.0630227,0.03781848,0.023488073,0.035361405,0.041019924,-0.083587356,-0.010202508,0.055934083,-0.053937763,0.020160235,-0.038766686,0.01983265,-0.07683112,0.11325844,0.07759586,-2.4065487e-08,0.041671723,0.011937243,0.054479335,-0.05669538,0.040172227,-0.04196145,0.05601579,0.07125518,0.03434308,-0.07578355,-0.049479827,0.12422622,0.015953768,-0.0066416166,0.117803805,0.0041452595,-0.026876658,0.02118923,-0.086368,-0.05639536,-0.023672435,-0.05151408,-0.08261507,0.013339981,-0.09970916,-0.08867603,0.10030853,0.031939115,0.013251103,-0.027975947,0.013781624,-0.024079852,0.0048810663,-0.072812825,-0.03638406,0.075073436,-0.0054748086,-0.08608368,0.006256447,0.056685153,-0.05832885,-0.04534078,0.008539537,0.018534765,-0.040998675,0.0058461595,-0.0032167789,-0.039728772,-0.039108474,0.049526006,0.029051797,-0.02975612,-0.055332545,-0.05523677,-0.05852076,0.005623911,-0.038083814,-0.0040765237,0.05482897,-0.044583865,0.009335727,0.01718754,0.13732031,-0.025957704 +1.1.1.23,Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase).,384,1.0,-0.03567557,-0.043438237,-0.011609946,-0.016964057,0.069031924,0.07840713,-0.08353266,-0.028445994,0.036288198,0.010340178,0.052679636,-0.013156117,-0.03573423,0.02985688,-0.05358823,0.0124329105,-0.12881424,0.011129395,-0.037720345,-0.0945344,0.071465336,0.00064200745,-0.011771813,-0.039789055,0.06701556,-0.020973211,-0.017843999,-0.017692816,-0.01949538,-0.10878252,0.00022192363,-0.013366362,0.018218478,-0.08424371,0.014469154,0.04516245,-0.099658,-0.077605575,0.0039211954,0.08092685,0.02544097,-0.027073782,-0.018236293,0.029717404,-0.039232906,0.016195418,-0.009192164,0.020947708,0.026276672,-0.05355105,-0.043712866,-0.027872086,0.051545247,0.02244541,-0.020274889,0.05766567,-0.083232835,0.0043758503,0.016571127,0.03816618,-0.015606829,0.083789654,-0.026916932,0.017616002,0.018524818,-0.03060624,0.009326567,-0.1064912,-0.043044776,0.031419665,-0.050984815,-0.10108263,0.0032540227,0.007509768,-0.0008604776,0.034815066,-0.022800896,-0.08924173,-7.970769e-05,-0.012357807,-0.006180562,0.028607368,-0.048999928,0.046902813,0.06894762,-0.033681255,-0.00055171765,-0.033685647,-0.003198913,0.06009858,0.01810906,-0.06883621,-0.0009414204,-0.035665367,-0.0823628,0.07692205,0.0119967675,0.083306536,0.0013349657,-0.04006455,0.028589625,0.13653105,-0.09132838,-0.061652873,-0.013041812,0.09859393,0.04175399,0.10985156,0.021854384,0.017001597,0.012627943,-0.030756302,0.007543405,-0.054080557,-0.04222667,0.11425768,0.0453619,-0.05511125,-0.08516078,-0.019735802,0.030856946,-0.056260664,-0.039521255,0.09152848,-0.035843123,0.084789045,-0.10254707,3.418662e-33,0.08002019,0.027758572,-0.040339805,-0.009223218,-0.003452416,0.00185565,-0.06822464,0.034850135,0.009254197,-0.057509903,-0.0662152,0.0030287562,0.0702119,0.00901504,-0.11172945,0.014649916,0.0425272,0.0011287184,0.035470136,-0.0076663583,0.05918199,0.0061876476,-0.044077646,-0.016230661,0.038551748,0.0170298,-0.06378901,0.0013324308,0.032682814,0.0057404726,-0.000186403,-0.080437794,-0.12835298,0.048644274,-0.021591304,-0.039872155,-0.040166337,-0.06096979,0.01945443,0.06457043,-0.03896605,0.061045967,-0.004228149,-0.015486423,0.031897325,-0.021076627,-0.004064583,0.09781057,0.111147314,0.012220144,0.036045264,-0.020505235,0.13655515,-0.05256162,0.038830407,0.03048294,-0.01704561,-0.016237235,0.05612431,0.092587076,0.013951262,0.07852614,-0.059762884,0.012852834,0.060608763,0.052756473,-0.021427706,-0.08768417,-0.021988917,0.006335195,-0.11328263,0.019507065,0.03547336,0.017422862,0.03509768,-0.04144358,-0.07395521,-0.029972816,-0.037838224,0.035046797,0.02371217,-0.061950773,0.047156874,0.018241677,0.0045716367,-0.0101239355,-0.0051138266,-0.029087618,0.01709821,0.031775683,0.036593232,-0.10837309,-0.006783532,-0.013388848,0.03524063,-3.4505667e-33,0.077340886,-0.09067,0.016548127,-0.10287428,-0.06769236,0.052903462,-0.0067020897,0.029561538,0.008642492,-0.010704255,0.017858366,0.0007379752,0.008889478,-0.08271743,-0.00019250448,-0.06365297,-0.012256205,0.07891448,-0.013907401,-0.008714963,-0.011058658,0.12356505,0.023439473,0.044686094,0.102872185,-0.0071630115,-0.022951804,0.049622376,0.022542333,0.017441573,-0.035858393,0.00841534,-0.026136538,-0.06264925,0.016102362,0.06325195,-0.10519259,-0.025620813,0.033883736,0.02557346,0.03145678,0.039987788,0.091038175,0.023292666,0.066926695,0.036584467,-0.11670863,0.019575747,0.03385355,-0.039402463,-0.013242522,0.025809065,-0.026154408,0.026255554,0.09783768,0.057416737,0.010729584,-0.011449578,0.040378593,-0.014519348,-0.016951032,-0.036641363,0.022704847,-0.028440313,-0.018410672,0.09548065,-0.06792907,0.08628744,0.049568985,0.05750172,0.046599265,0.008280688,0.041645292,-0.02740243,-0.07487363,-0.025176886,-0.012730329,0.010177052,0.035417646,-0.04622001,0.057159066,0.008883325,-0.0053378693,-0.06116483,-0.029703828,-0.03605436,0.0055602156,0.09302597,-0.022516334,0.03206584,-0.0051649837,-0.068763725,-0.032227077,0.08110977,0.07279231,-3.804448e-08,0.051508613,0.022297557,0.091890156,-0.023709733,0.033617783,0.06638414,0.06538879,-0.0051714913,0.053603414,0.032985676,0.033219673,0.06502362,0.09631,-0.06109245,0.06593268,0.010550802,0.03232183,0.060276642,-0.018071283,0.050691333,0.007015218,-0.021128291,-0.07887961,0.047832925,0.042999435,-0.081660226,0.088889204,0.042505354,0.011600384,-0.047839183,-0.047879763,0.0008543979,0.028951095,-0.013591938,-0.0013320834,-0.011169946,-0.11690837,-0.04744467,-0.027066657,-0.022319354,-0.053746533,-0.021000892,-0.060453553,0.030433394,-0.03384999,0.006338495,0.016910763,-0.008832062,0.007762152,0.0042188843,-0.0010043596,-0.060737584,0.004203145,-0.06358908,-0.08965631,-0.018186653,-0.004198796,-0.045110095,-0.040913153,-0.083082855,0.027283447,0.03730676,0.15551428,-0.01420857 +1.1.1.24,"The enzyme, found mostly in bacteria (mostly, but not exclusively in Gram-positive bacteria), fungi, and plants, participates in the degradation of quinate and shikimate with a strong preference for NAD+ as a cofactor. While the enzyme can act on both quinate and shikimate, activity is higher with the former. cf. EC 1.1.5.8, quinate/shikimate dehydrogenase (quinone), EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+], and EC 1.1.1.25, shikimate dehydrogenase (NADP+).",384,1.0,-0.07802531,-0.014165629,-0.042495348,-0.075293936,0.082898565,0.08110989,-0.073795274,0.036404897,0.07909086,0.048195813,0.03257456,-0.015705913,-0.011990134,0.009173901,-0.04502654,0.032620355,-0.04677826,-0.024121929,0.002488801,-0.053189944,0.024873113,-0.029951314,-0.049881365,-0.05190807,0.043884076,0.035987988,0.039099403,-0.023640286,-0.05350277,-0.05187202,-0.004903409,0.043106575,0.011813886,-0.0070518246,-0.062537126,0.14950979,-0.050808057,-0.044784598,0.027356056,0.01739578,-0.02457912,0.075229265,-0.010736965,-0.06817145,0.023856854,-0.0039125523,0.0039787595,0.015480052,0.013312947,-0.037457876,-0.07205273,-0.006171627,0.07269769,-0.009228375,0.06932267,-0.07427381,0.0515593,-0.04710225,-0.09680682,0.016800834,-0.006908463,-0.038328573,0.0016241414,-0.037003707,-0.007342979,-0.07469679,0.040629797,0.009964026,0.013061059,-0.049656816,-0.13499054,-0.007735465,-0.015092543,0.00490214,-0.0081956955,0.044798307,-0.025764637,-0.07485747,0.022019684,-0.04474359,0.016505359,0.032694023,0.027278893,0.04162666,0.07144394,-0.030369172,0.062813714,-0.034007326,0.024770468,0.051839847,0.064534575,0.015231832,0.0001749281,-0.02710738,-0.057054557,0.07996246,-0.0082493285,0.0034739424,0.023059549,-0.09238035,0.029033609,0.06081318,-0.06330437,-0.0653794,-0.07052353,0.030557012,0.0073929927,0.15568015,0.009638999,0.01567673,0.0018009781,-0.017113026,0.0055906516,-0.025764838,-0.054385368,0.119878724,0.06393365,-0.03664612,-0.053016327,-0.019297488,-0.028581673,0.010294642,0.06694206,0.052045323,0.01462332,0.04202341,-0.09158747,-2.7419333e-34,0.07444996,0.043548748,-0.048091117,-0.02374409,-0.0504671,-0.006659362,-0.098190606,0.047518075,-0.0670314,-0.09480435,-0.023037955,0.018009368,-0.0081104515,-0.056519568,-0.0076624574,0.03708516,-0.032132644,-0.09971379,-0.010034332,0.04243525,-0.026846671,0.03000711,-0.0278213,-0.013410353,0.04055229,0.04441913,0.06466815,0.010139166,-0.0873187,-0.04451696,0.04784181,-0.08171752,-0.10555391,0.071319915,0.09025058,0.025834009,-0.021676168,0.02125894,-0.074520275,0.07065372,0.020888193,0.057778094,0.04932542,0.0028803258,0.06265939,-0.08389966,0.0030833487,0.08860617,0.04461037,0.056296155,0.02813802,0.051627707,0.12516646,-0.06689868,-0.10236885,-0.0039955787,0.036659833,-0.029764224,0.048908237,0.07935622,-0.0057584234,0.031017436,-0.035458058,0.011975071,0.0010590883,-0.026166044,-0.07211375,-0.04201312,0.047553387,0.12192383,-0.027223341,-0.029543726,0.05122459,0.04458024,0.03818892,-0.055927373,-0.02709861,-0.0045557553,0.010582811,0.04120833,0.037801273,-0.068222724,0.026233202,-0.0238905,-0.07120787,-0.0047382163,-0.016093425,-0.06922071,-0.03360215,0.020774294,0.02352965,0.014261507,-0.013607516,0.016352696,0.06465284,-1.7205782e-33,0.04380186,-0.04389366,-0.004015516,-0.02597653,-0.0815466,0.13401662,0.0012997594,-0.028823286,-0.028578598,-0.048856597,0.0648298,-0.0358669,0.059039187,-0.0068370523,0.019586384,-0.017593037,-0.032048054,0.0632075,-0.06434001,-0.023418067,-0.0364591,0.14076631,0.020753806,-0.0008822581,0.06095295,0.04181584,-0.054280717,0.06897618,0.014856503,0.011615988,0.03241637,0.0047595366,-0.04912055,0.014478106,-0.017718302,-0.008296586,-0.085502416,-0.025506312,0.003809063,0.03201021,0.024424372,0.023448823,0.038763475,0.0913961,0.026683653,0.05909344,-0.121061146,0.036076337,0.03989998,-0.048475157,0.019930633,0.052752063,-0.023813613,0.03444375,0.061020643,0.03930964,-0.0058339057,0.023282466,0.03159582,0.028287355,-0.044592105,-0.034577213,0.04672058,0.017147345,-0.02006819,0.01384232,0.02767471,0.045024198,0.063061416,-0.0138550885,0.051288832,0.06051626,-0.001949624,-0.014808998,-0.08649239,0.028014626,-0.047471613,0.019391388,-0.01931069,0.018018482,0.06395859,0.0029471568,-0.036384847,-0.09347738,-0.057781145,-0.059798233,-0.008004474,0.063367285,-0.022990106,0.019693684,-0.009736401,0.01798927,-0.07913101,-0.026162995,-0.000687669,-3.9760298e-08,0.00036585328,-0.07066874,-0.022759072,-0.050544214,0.0058409907,0.008728958,0.028921068,0.0039428826,0.036879018,0.018064095,0.007091137,0.08864248,-0.07030295,0.021427715,0.07027423,-0.012889818,-0.0029848036,0.022005294,-0.009400536,0.06419777,-0.078741975,-0.031897042,-0.15260676,0.033764593,-0.007323006,-0.050673127,0.023633296,-0.006284121,0.02017681,-0.08546305,-0.033104427,0.038751308,0.022261135,-0.009188624,-0.052109,0.06501679,-0.02599596,-0.027965391,-0.051382344,0.05344256,0.0322499,-0.046847392,-0.13154837,-0.018690662,-0.008233806,0.005920052,0.082929656,-0.054131478,-0.04878673,0.017148722,0.040402558,-0.018831491,0.0758658,-0.048274714,-0.11174602,0.06378358,0.017025426,-0.124665044,0.014013397,-0.042850524,0.03786941,-0.070635974,0.1364184,0.036911678 +1.1.1.25,"NAD+ cannot replace NADP+ [3]. In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10, 3-dehydroquinate dehydratase [4]. cf. EC 1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC 1.1.5.8, quinate/shikimate dehydrogenase (quinone), and EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+].",384,0.99999994,-0.094727,0.023883047,-0.0011953602,-0.11565195,0.0491844,0.023667773,-0.082507476,0.010868957,0.014290896,0.031762265,0.018324213,-0.058577035,-0.06977675,-0.0025121586,-0.0081118625,-0.0008253701,-0.08408246,0.0055804956,-0.00419933,-0.015159667,0.0069994354,-0.018091314,-0.017188052,-0.011849479,0.07735183,0.047950294,0.027071133,0.04411666,-0.053113043,-0.06144166,-0.015287943,0.027114676,-0.0064651156,-0.05310021,-0.049875323,0.081362806,-0.08547274,-0.035155527,-0.0030083247,0.03897853,0.022102334,0.044451702,-0.074447654,-0.021641029,-0.0010637797,-0.019904416,-0.0218989,0.051258538,0.049484055,-0.014205447,-0.06259752,-0.0024101324,0.042085443,0.0087935915,0.06578374,-0.064876586,0.02234611,0.004509833,-0.078357264,-0.053644657,0.025356611,-0.07133618,0.024089087,-0.021482686,0.029251406,-0.005675191,0.07138886,-0.017977104,-0.010835684,-0.010904716,-0.13920853,-0.012313166,-0.00037639067,0.020031167,-0.011233772,0.08815184,-0.06528195,-0.011711244,0.0341154,-0.017922958,-0.001318276,0.020782815,-0.031452868,0.011446017,0.09226508,-0.04587576,0.002542678,-0.03417002,-0.005786267,0.016962796,0.018491559,-0.012802618,-0.008234971,0.038714014,-0.08592627,0.10743751,-0.01634249,0.017039191,0.028254103,-0.0946171,0.04733786,0.12511945,-0.05355268,-0.054441154,-0.028789736,0.02230104,0.0018540885,0.15568763,-0.097902544,-0.0091140745,0.0002899314,-0.06185338,0.039224144,-0.04048065,-0.032837205,0.13631439,-0.0047700903,-0.024151463,-0.043102246,-0.033874128,0.033848837,0.0055886894,0.07329599,0.029908,0.0179573,0.0120246755,-0.09450403,2.9725692e-33,0.090231426,0.05804509,-0.03248263,0.019438421,0.023205748,0.037105568,-0.114413805,0.09638746,-0.0960509,-0.07465143,-0.034374136,-0.029592017,0.023311172,-0.06673707,-0.029226776,0.038044583,-0.02215218,-0.102839656,0.009579755,0.04110941,0.018142497,0.045306955,-0.040035672,-0.016490128,0.04816821,0.092964284,0.02281275,0.028026555,0.00018194922,-0.017350735,0.035485998,-0.12511642,-0.111423925,0.03792231,0.038977146,0.0024920725,-0.033128418,-0.036499962,-0.037458945,0.06285863,-0.0561227,0.044349782,0.058526836,-0.042408504,0.058913738,-0.040310517,0.037444595,0.06464897,0.01503638,0.028906362,0.0005751099,0.014412917,0.12026165,-0.09170535,-0.11036903,0.026221944,-0.0015553106,0.04250003,-0.0061574588,0.085993715,0.04171299,0.07291308,-0.024532547,0.03984874,-0.020152755,-0.013813583,-0.075916946,-0.031382166,0.056647357,0.07166298,0.009321462,-0.0040195747,0.06862335,0.027542666,0.06825432,-0.04893771,0.0061268727,-0.005932245,-0.025637396,0.05219783,-0.029827544,-8.227895e-05,0.017961066,-0.0136122415,-0.016361918,-0.010819911,0.008391549,-0.01596748,0.027358979,0.059061244,0.02468036,0.020453399,-0.00040103061,-0.044245332,0.057366583,-3.5631273e-33,0.038269643,-0.03768355,-0.0013592616,-0.067026,-0.06525995,0.15519038,0.04120077,-0.06991388,-0.019719992,-0.06148509,0.07835789,-0.02786402,0.020934265,-0.06374674,0.015777137,-0.022601735,-0.101644434,0.060643546,-0.02241857,-0.005255326,0.019848173,0.14561589,0.035415415,0.014526574,0.045424014,0.014478898,-0.031492442,0.07044026,0.053716972,0.015397697,-0.008921265,0.006351919,-0.07009876,0.05582377,-0.0066207615,0.021107253,-0.052869607,-0.016703177,0.00050294446,0.05025695,0.013020357,-0.0275602,-0.0217734,0.019354282,0.06006791,0.0322024,-0.09865022,0.02193174,0.029554041,-0.042035885,0.041387144,0.034152452,-0.059730507,0.026522592,0.09720708,0.027366176,0.031209163,0.005991837,0.08103897,-0.0035265018,-0.03818115,-0.07539913,0.079707034,0.0102860285,0.019786475,0.01153679,-0.015722068,0.034897268,0.054235525,-0.025819404,0.040609375,0.01342486,-0.056427155,0.005442764,-0.004086183,-0.01012935,-0.049406912,0.05022628,-0.031997122,-0.028410122,0.05626136,-0.03365605,-0.04147213,-0.054310873,-0.018748585,-0.025705688,0.017739225,0.086021185,-0.068968914,-0.015964482,0.0030765093,0.086154655,-0.073064566,0.03764001,-0.003830993,-4.1509487e-08,0.047088884,-0.051929962,-0.017619567,-0.044648632,0.059501823,-0.016015831,-0.014984851,-0.010513951,0.025814803,0.055262674,0.016489876,0.0669112,0.052729603,0.022861172,0.059359763,-0.017416174,-0.00022750146,0.0029742485,-0.023111954,0.018389935,-0.06423087,0.015250826,-0.18869352,0.020476712,0.038500942,-0.035848282,0.0052383374,-0.06886823,0.034701295,-0.059796177,-0.0019419831,0.0148165915,0.026978472,0.002469458,-0.028438808,0.01839733,-0.043036688,0.023054214,-0.05301141,0.040726814,-0.023557035,-0.09857561,-0.1060852,0.019942014,0.049905777,-0.005374126,0.078609936,-0.04109061,-0.061564673,0.026211612,0.048781343,0.0014212271,0.11200136,-0.0835978,-0.0859083,0.057132326,-0.009842059,-0.08457591,0.007847787,-0.030084873,0.059978317,-0.08483602,0.08770179,0.015863644 +1.1.1.26,Reduces glyoxylate to glycolate or hydroxypyruvate to D-glycerate.,384,1.0,-0.026247583,-0.0069781444,0.034853082,0.080731794,-0.02452037,-0.0076562976,-0.031399697,0.0076358635,-0.06194273,0.003147784,-0.074268416,0.068080135,-0.052134316,0.0051580006,-0.027422281,-0.051725708,0.07422463,0.05376206,-0.0010588818,0.018021513,0.10769546,-0.033302903,0.011970507,0.013816388,0.08420216,-0.01428993,0.05454553,-0.03963105,0.048135977,-0.012510638,-0.05384864,-0.010502321,0.037568264,-0.026149612,0.005269635,0.080271274,-0.005386386,0.049265817,-0.047536887,-0.05482827,0.040979713,0.05168589,0.023947041,0.0001471746,-0.064092554,0.003258953,0.03571484,0.030386586,-0.003833385,0.025351113,-0.02664179,-0.06285931,-0.10270793,0.00022858511,0.024307085,0.07313569,-0.018728722,0.061514437,0.016875032,0.021052226,-0.04277979,-0.018535921,0.062011685,0.011753048,0.026893763,-0.05255083,0.06253708,0.013331138,-0.023680013,0.0062164804,0.0033192977,0.0026206106,0.045597527,-0.03992852,-0.001371623,0.030430097,-0.055973377,-0.07897907,0.08424129,0.018943751,0.094863385,0.056987707,0.05885282,0.12302067,-0.061592977,-0.007249814,-0.001971799,-0.060939137,-0.043010954,-0.06359883,0.0028625848,0.009484367,-0.018365556,0.056461323,-0.113512635,-0.022785943,0.07702308,-0.019062921,-0.015186374,-0.029617362,-0.015631733,0.0789132,0.0042874445,-0.072488666,-0.08358873,0.033972215,-0.009612939,0.022922449,0.038518917,0.0042564687,0.021242358,0.06354638,0.036251724,0.072713956,-0.09503822,0.028987197,0.048194878,-0.00010659964,-0.067334734,0.0031485327,-0.01858942,-0.05184579,0.08133029,-0.03853846,-0.088091575,0.03412211,0.03534783,4.8486295e-33,0.03697018,0.028089726,-0.026906328,0.03049627,0.017612996,-0.02095513,-0.093215525,-0.04496561,-0.007919587,0.031551167,-0.049395133,-0.048067458,0.023933444,0.105553955,-0.034688726,0.0060637384,-0.06978079,-0.01858386,0.08990441,-0.05951835,0.09894417,-0.0017161425,-0.019790672,0.020087138,0.031946864,-0.0054736524,-0.020524755,0.052915473,0.016760327,-0.030498207,-0.015260258,-0.09287459,-0.02045468,0.025183031,-0.030945493,0.05133595,-0.092352666,-0.11262202,0.037670713,0.023189925,-0.04034856,0.02096784,-0.004915007,-0.085093506,0.013967491,-0.0015467446,0.007414321,0.09031525,-0.028881934,0.10918718,0.09486891,-0.06076282,0.030467521,-0.017356507,-0.08063952,0.010699345,-0.017332094,-0.0758311,0.06657224,0.055724062,0.0071112975,0.03380691,0.026877066,0.022789052,0.030256506,0.024941,-0.08234736,-0.031585608,-0.07263708,-0.02934804,-0.04899212,-0.042360928,0.10691792,0.0020686812,-0.04768514,-0.12383305,0.041115995,0.008633769,0.030682974,-0.06218155,0.01990537,-0.024850564,-0.054219164,-0.016591895,-0.0093011195,0.03904413,-0.021984253,-0.02692016,0.033376954,0.019208524,-0.052975312,-0.071530804,-0.007474394,0.032483436,-0.080370165,-5.7694053e-33,0.056252155,-0.11048776,0.03177706,-0.0019983482,-0.012252403,0.007088809,0.042952806,-0.0098852245,0.05962002,-0.059675146,0.012634092,0.046387427,0.020981057,0.03368394,-0.035897885,0.07009489,0.035041507,-0.046571437,-0.10279855,-0.019064719,0.015556169,0.017541487,-0.062281005,-0.024798384,0.07422081,6.84856e-05,0.01966536,-0.0047587063,0.02381199,0.11825114,0.050850153,0.052661747,-0.07764774,-0.07888317,-0.025364742,0.10004747,-0.07526317,-0.057466958,-0.061498966,-0.032236706,-0.054444503,0.07563781,0.07796286,0.06334167,0.078684814,0.094234236,-0.08268125,-0.040235348,-0.015230403,0.022780482,-0.010943894,0.0059478674,-0.03652461,0.098972864,0.016891083,0.05236791,0.07571172,-0.03981172,-0.056043055,0.0041120946,-0.05617482,-0.06235544,0.013907596,-0.059811417,0.0496978,0.03392315,-0.04423663,0.008904754,0.039561223,0.034945752,0.07518059,-0.002634794,0.016019125,0.02647659,-0.014708301,0.017700275,-0.024164198,0.023666697,-0.038613714,0.005824872,0.028926315,0.05461789,-0.032512467,-0.041370764,-0.01900967,-0.048284553,-0.051953714,0.14156732,0.007869498,0.05486814,-0.045451418,-0.08617286,0.014762946,-0.079243176,0.09855186,-2.8197034e-08,-0.025422648,-0.04757403,0.05186476,-0.044584926,-0.05620665,-0.022675708,0.032380383,0.07253954,0.001975532,-0.08562533,0.018369675,0.058901772,-0.007708277,-0.035565086,-0.022133248,0.055790868,-0.058668874,0.03597014,-0.07720324,0.014846276,-0.12728192,-0.08026453,-0.08002598,0.0902288,-0.00071931875,-0.07855167,0.11237491,-0.008373521,-0.042939723,0.002313961,0.025133833,0.02925922,0.005476505,-0.004139971,-0.038631115,0.026225155,0.054303177,0.050623775,0.014431121,0.009608157,-0.043401115,-0.08993681,0.014643089,0.026949277,-0.030308653,-0.024764717,0.0050783847,0.032436352,-0.022364454,0.090014204,0.037830885,-0.045509715,-0.06067869,-0.064064905,-0.06190937,-0.013114843,-0.017746009,0.03984445,-0.0065576173,-0.053332996,-0.05895429,0.044930585,0.11297787,-0.05434781 +1.1.1.27,"Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme.",384,0.99999994,-0.030224467,-0.05480839,0.027907826,0.054706708,0.07825438,0.085256584,-0.10455812,0.037402485,0.065861665,0.02546082,0.022513982,0.04889208,-0.0203999,0.11529095,-0.008728199,0.07586502,-0.0065299203,0.057353996,0.04832792,0.004542852,0.026305832,-0.0044921916,0.0037339788,-0.028243773,0.063350916,0.042145286,-0.019676996,0.00624388,-0.014709368,-0.04072225,-0.009272851,0.05686683,0.0014488467,-0.061618697,-0.03300025,0.049218733,0.0035465676,-0.025852231,0.05206881,-0.0072050793,-0.028744392,0.013008164,-0.05818585,0.007631001,-0.0005943714,-0.031932864,0.025260385,0.010767647,0.029325465,-0.03268062,-0.06503417,0.023915622,-0.037417535,0.037055764,0.0066714087,-0.0072373096,-0.00317845,-0.023733035,-0.038819898,-0.11721267,-0.028216263,-0.056650307,0.06283148,0.07120905,0.04241022,-0.040115763,0.056702852,-0.023977853,-0.049803086,-0.030205393,-0.107943304,-0.03442934,0.029008657,0.026678473,-0.009717202,-0.01650333,-0.043861017,-0.08209376,0.10601598,-0.01484166,0.0092981085,0.01781608,-0.0765116,0.113038115,0.06574656,-0.03751434,-0.013194007,-0.055350732,-0.10379408,0.0054641264,-0.0053931866,-0.022436641,-0.029526936,-0.0043456503,-0.080000244,-0.03746278,-0.0007329772,0.02410884,-0.031765595,-0.043892626,-0.053240042,0.08917472,-0.04903635,-0.10878138,0.028451093,0.010340455,-0.040208578,0.10305627,-0.005157986,0.05133559,0.022997748,0.020322943,-0.00944628,-0.0051250975,0.016060272,0.14467947,0.018869659,-0.027244579,-0.12728116,-0.04309796,0.03770266,-0.087129794,3.8184928e-05,-0.014842428,-0.027927695,-0.0015228981,-0.0057224734,-1.5552595e-33,0.093697496,-0.05139432,-0.047540646,-0.02896353,0.059471365,0.008396188,-0.09356712,0.039057717,0.055827275,-0.0131782405,-0.06970664,-0.04510179,0.051639117,0.03321784,0.016781006,0.017996917,-0.04148628,-0.05308103,0.059426796,-0.019360512,0.021107614,0.05997822,0.04001243,-0.010097159,0.06782748,-0.012504568,-0.029411307,0.023956833,-0.03810753,-0.009021279,0.040060434,-0.07802533,-0.1449967,0.045006823,0.051712975,0.032665297,-0.049945522,-0.11089962,0.016895395,0.03656041,-0.06920473,0.05942424,-0.026105242,-0.05420834,0.06775703,-0.07937992,-0.09260072,0.09108188,0.031424608,0.07374064,0.067156605,-0.044538733,0.07659666,-0.04599472,-0.026067857,0.035772298,0.019264925,-0.048413828,-0.057879884,0.06721843,-0.0007744568,-0.0021493484,-0.029531594,0.056065433,-0.0031902108,-0.0052361544,-0.048774403,-0.040492315,0.010091272,0.028229807,-0.018511686,0.06043768,0.06358548,-0.002873778,-0.039289754,-0.045573432,-0.0040479354,0.034974918,0.091470495,0.03678451,0.0042100954,-0.065051384,-0.014746549,0.023757186,-0.01952431,0.058947455,0.050367184,-0.0043658507,0.03305585,-0.014297079,0.09318968,-0.063317,-0.050842922,-0.048009858,0.047562443,-5.928534e-34,0.06515967,-0.07155445,0.00041384576,-0.053448938,-0.027476046,0.06557781,0.016423132,-0.01793576,-0.022123754,-0.043755226,0.03171759,0.037748728,-0.009704495,-0.0105047,0.05864333,-0.030345801,-0.01992325,0.06745973,-0.043207813,-0.067964345,0.005004491,0.099360965,0.071774304,-0.012111889,0.0803201,-0.041574433,-0.11637667,0.019206308,0.051193394,0.03964475,0.042760797,0.03447746,-0.07208482,-0.07365288,0.0865336,0.039796412,-0.078560695,-0.0056327954,-0.029869674,0.015916523,0.04868003,0.003474736,-0.028025217,0.042791445,0.07641617,0.04945155,-0.13765284,-0.07639214,0.031513397,-0.04419931,0.047229376,0.044450954,-0.084216066,-0.007831867,0.097845934,0.027203053,-0.043597735,-0.025372194,0.07018256,-0.034636527,-0.05685808,-0.02517038,0.0152108865,-0.017753538,-0.011750547,0.015079806,-0.022043569,0.0053325444,0.1075938,-0.03695129,0.05762719,0.04611882,0.014839468,-0.001709241,-0.036614385,-0.03314149,-0.057837505,0.01099064,0.014672028,0.017509583,0.014779746,0.00052101916,0.00076559,-0.033378925,-0.080077656,-0.04706191,-0.026701875,0.096991114,-0.010722746,0.023526464,-0.038460255,0.042204745,-0.0013994997,0.017401153,-0.010407046,-2.984231e-08,-0.018298402,0.0020849237,0.12837993,-0.021843959,0.006012498,0.06308229,0.007209652,0.023997065,0.029104607,-0.025329592,0.031655792,0.14581937,0.05329127,-0.011388408,0.05690945,-0.014445316,0.0072247405,-0.044838563,-0.013864437,-0.03994595,-0.10276218,-0.0025261822,-0.057074904,0.07697694,0.0184657,-0.06166158,-0.0064961067,-0.049907442,0.047590647,-0.0678393,0.0049804533,0.021872275,0.0256254,-0.007352789,-0.054262016,0.004439714,0.002876023,-0.045754477,0.0006800425,0.07251627,-0.05755125,-0.046552382,-0.08339701,0.021955753,0.088523045,-0.0013914187,0.046902366,-0.026270937,-0.10805654,-0.039310627,0.04049132,-0.03349675,-0.039457016,-0.067394264,-0.10138129,0.053640377,0.03330673,-0.0787225,0.0050809784,-0.039517038,0.0011087228,0.030359803,0.12917078,0.012730062 +1.1.1.30,Also oxidizes other 3-hydroxymonocarboxylic acids.,384,0.99999994,0.013847444,-0.108178206,0.013029951,0.0344055,0.090443775,0.029931257,-0.045128502,-0.0154340165,0.0555626,-0.041376997,0.03072693,0.01643542,-0.018399147,0.0321428,0.024817538,0.13381954,-0.03207772,0.08072317,-0.026283752,-0.019714415,0.05593008,-0.0128245605,0.020553473,-0.0039522885,-0.010044268,0.036699887,0.009218537,0.021019822,-0.032741956,-0.07061577,0.04870583,0.05516705,0.0021185998,-0.034796305,-0.045414258,0.027861,-0.060954347,-0.055654902,0.037943333,0.05469147,-0.0232004,-0.016880473,0.01468845,-0.047465567,-0.03879846,-0.05148726,0.012643309,-0.030850261,0.030962214,4.3651813e-05,-0.006681712,0.00059149676,-0.06292776,0.03756942,-0.010841505,0.027940854,-0.055785805,0.043041795,0.014297118,0.03700772,-0.018105406,0.03752014,0.011309014,0.030960457,0.02836301,-0.038132098,0.007585888,-0.039390083,-0.0015826542,-0.0069736135,-0.028575478,-0.042789936,0.014129829,-0.019133272,-0.011146271,0.05278833,-0.0026185568,-0.080879994,0.062365882,-0.004580764,-0.05124309,0.034578487,-0.05073599,0.16417612,0.065632425,-0.07960024,-0.054300573,-0.099568784,-0.11421163,0.023593733,-0.008554839,0.03546631,-0.027804902,0.02899418,-0.03532916,-0.0025710387,0.035624184,0.052937508,-0.061186217,0.007764029,-0.05387714,0.0744617,-0.07119437,-0.11014705,-0.024128912,0.008765136,-0.040489808,0.08675615,0.003820251,0.0356376,-0.0006332765,0.015454793,-0.014352065,0.0026668555,-0.053946983,0.11360778,0.026921768,-0.036076188,-0.07912283,-0.020693965,0.01505829,-0.06711534,0.018167637,-0.03025149,-0.08169488,-0.043625753,0.049767043,1.81585e-33,0.06304564,0.01648084,0.02707672,0.003111066,0.009730342,0.006715972,-0.11033406,0.0037338885,0.07216945,-0.0020845272,-0.030868921,0.086598784,0.0633882,0.05616053,0.0025988177,-0.021902394,-0.059314966,0.017664198,0.030354569,-0.0025807933,0.014843324,0.026428694,-0.010024791,-0.01490263,-0.03865567,0.019245502,0.013262144,-0.02825157,0.008585541,0.007106341,0.0363527,0.036430277,-0.081985205,0.051342063,-0.050958734,0.04730593,-0.11248813,-0.077293076,-0.0020625233,0.061748266,-0.04483006,0.02844926,-0.013256143,-0.05993693,0.050452534,-0.06254816,-0.06389866,0.08420081,0.009752218,0.03381073,0.028395874,-0.019380094,0.040875535,0.020678595,0.010723075,-0.038253002,0.015761228,-0.06125289,-0.010766892,0.010856507,-0.045556094,-0.010305965,-0.029521013,0.031641174,0.0032420536,0.009391068,-0.0379579,0.019874828,-0.050196625,-0.02075824,-0.036458705,0.04505801,0.08535261,0.037734453,-0.047653064,-0.0287056,-0.05847687,0.004627785,0.07865307,0.025843931,0.04275768,-0.07004919,0.055215098,0.022986125,-0.07360193,0.013185936,0.025377695,-0.0083424905,-0.0008027921,-0.011683588,0.049015533,-0.09125601,-0.027090352,-0.061104555,-0.04260884,-3.6590175e-33,0.07025443,-0.07835715,-0.053214718,-0.07266763,0.04254724,-0.03407908,0.021789256,0.050103076,-0.025083186,-0.03767753,0.066338405,0.0060560163,-0.011819577,-0.055597298,0.05180376,-0.01039365,0.01738614,0.073501304,-0.055625625,-0.03428908,0.07859712,0.08529335,0.021684768,0.062918775,0.06902475,0.0019814514,-0.06019375,-0.06772592,0.058630202,0.13572465,0.020060105,0.021457523,-0.024441658,-0.022080183,0.08023008,0.055458,-0.061360482,-0.021791782,-0.024162412,0.033399213,-0.0019069251,0.00044301705,0.055920135,0.04232854,0.067161664,0.091021,-0.10886093,-0.039925568,0.0032430538,-0.0032553189,0.034840606,-0.03295495,-0.0961389,-0.0071288575,0.05251887,0.04252612,-0.034520455,-0.10087755,0.01762127,-0.037759893,-0.074806266,0.012924706,0.049419492,-0.07122393,-0.09425433,0.05643617,-0.02235047,0.088523716,0.07134215,-0.012246694,0.14636645,0.008496511,0.039432358,-0.0067481846,0.0072370856,-0.07729328,-0.008289253,-0.009928007,-0.055758372,0.03170781,0.031999797,0.0042694854,0.044340402,-0.059570543,-0.02200844,-0.083620735,-0.03006205,0.06502919,-0.0639259,0.029828658,-0.040497728,0.02533263,-0.0034742772,0.057441257,0.040921304,-2.3342924e-08,-0.016908826,0.0025247836,0.14916527,-0.005715424,-0.07362093,0.058618076,0.08538897,0.11225151,0.022812871,-0.07923275,0.044731468,0.067120284,0.04691546,0.0076995892,0.030611938,-0.048815444,0.0021464275,-0.010346553,-0.037251983,-0.050108645,-0.14576934,-0.013830132,0.034726504,0.01821307,0.006059702,-0.028004888,0.03871895,-0.045795478,0.016127916,0.01944649,0.008762742,0.027926149,-0.00030786663,0.00079809356,-0.04719579,0.043816596,0.007760486,-0.05255907,-0.07509447,0.0005482403,-0.06493617,-0.03610791,-0.117574856,0.04301795,0.13051952,-0.06026999,-0.057504665,0.072836384,-0.059296694,0.018384311,0.03092184,-0.004409663,-0.03676622,-0.03923184,-0.09387405,0.012013977,-0.011083236,-0.039208207,-0.007463322,-0.0651169,-0.0016702232,-8.600563e-05,0.20250744,-0.004277832 +1.1.1.33,May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)].,384,0.99999994,-0.07888261,-0.00014831801,-0.053719867,-0.021604875,0.06492238,0.0022278735,-0.09134754,0.07102813,0.036051508,-0.068930134,0.051732983,-0.046371855,-0.11009172,0.022488302,-0.0510676,-0.011783007,-0.0006665759,-0.09250768,0.064808704,0.0035100696,0.015974047,0.061509,0.03283213,-0.004989684,0.09067241,0.0742062,0.009753474,0.10754901,-0.00026104297,-0.090145975,0.06062751,0.026937844,0.021918153,-0.06440482,0.0144467475,0.003515311,-0.028709725,-0.06562821,0.009180695,0.038885165,0.05645757,0.03138011,-0.03426996,0.02196912,-0.055938147,-0.033885557,-0.061255027,0.10405072,-0.016041428,0.00082294137,0.036206707,-0.032309912,0.010907488,-0.018014468,0.09721887,-0.031597298,-0.0469732,0.021995572,-0.05586831,-0.0037538817,-0.02907345,-0.018619334,0.036096103,0.05866419,0.05292008,-0.028882112,0.08494542,-0.11650131,-0.0052821934,-0.051553838,-0.1328949,-0.068227306,0.045454927,0.07355094,-0.050695874,0.06833337,-0.06440291,-0.040071383,0.034813736,-0.021665964,-0.0028511055,0.013956641,-0.058981974,0.01365065,0.02247219,-0.0050205267,0.06780749,-0.045944326,-0.03693818,0.014595557,0.019650815,-0.02848869,0.014099239,0.029929545,-0.069637306,0.07652636,0.03834818,0.09374715,-0.011624992,-0.06910829,-0.03771609,0.14582603,-0.037012286,-0.025938664,-0.02922949,-0.018904736,0.018364972,0.061970647,-0.03171981,-0.020028235,0.008539622,-0.061862223,0.038061716,0.0040953974,0.00994124,0.05887042,-0.003284006,0.00038771276,-0.000912539,-0.014699162,0.033312406,-0.06670705,0.023839707,0.04569613,-0.028341925,0.022000732,-0.09184728,-2.2053477e-33,0.037041314,-0.0047932416,2.3149838e-05,-0.013956776,0.039513316,-0.034445588,-0.103296824,0.07268527,-0.06685874,-0.029649088,-0.064909436,-0.023715999,0.052872602,-0.030665044,-0.040320396,-0.023583187,-0.043327063,-0.0020008883,-0.009774207,-0.02327535,0.0018293465,0.037946302,-0.016476931,-0.0046630604,0.031640083,0.037772067,-0.01549575,0.027356418,0.041978147,-0.011556497,0.014756265,-0.061290417,-0.096904725,0.009345992,-0.03349195,0.019835886,0.021110993,-0.06047849,0.009608514,0.029457342,-0.03141617,0.09969255,0.057677,-0.06847185,0.035272542,-0.07597314,-0.07916114,0.04864821,0.06442006,0.026914315,-0.015382333,-0.012694863,0.12419634,-0.10044453,-0.011772972,0.03252875,-0.020673972,0.057459082,-0.014527087,0.08557325,0.017950766,0.10850305,-0.046490286,0.0058204243,-0.019984748,0.021892479,-0.082784645,-0.08890127,0.041665453,0.024551762,-0.0064418083,0.039529663,0.108962335,-0.02297283,0.031912193,-0.015383351,-0.018757565,0.03598826,-0.019169725,0.05427351,-0.11108084,0.011297496,-0.021539656,-0.049883265,-0.049250215,0.037143838,0.0018997097,-0.008858912,0.018838111,0.079024345,0.05105662,-0.016729545,-0.014020117,-0.037407476,0.022623997,-1.3018506e-34,0.028894888,-0.060190573,0.032799408,-0.06659583,0.003689205,0.12317537,0.054128833,-0.03195743,0.0032928702,-0.015641818,0.14160934,0.039782558,-0.031525865,-0.06765139,0.07787397,-0.02514889,-0.08794486,0.053785134,-0.020085415,0.05557301,0.030548573,0.11960098,0.024964908,0.007627527,0.052376825,-0.012748218,0.012874562,0.023718549,0.023960317,-0.018254735,-0.024297211,0.03587895,-0.08964907,0.0008942608,-0.01715438,0.029940367,-0.061058946,-0.056343112,-0.018392421,0.0015112075,-0.016260404,0.03952831,-0.0769457,-0.0009522979,0.09161972,0.03711704,-0.022878302,-0.036220253,0.0581303,-0.06731138,-0.009485664,0.062492557,-0.08915841,0.061915636,0.028582983,0.032226082,0.013074716,0.056730267,-0.00038585637,0.0051091453,-0.013547624,0.016239615,0.04646418,-0.0028614462,0.0039379047,-0.0054969965,-0.0356442,0.04757386,0.019962516,-0.031242494,0.08084146,-0.02907655,-0.010312095,0.02755059,-0.0224988,-0.101421244,-0.04774472,0.017329263,-0.04966141,-0.040708568,0.024139538,0.042926867,-0.053318564,0.0072127627,0.006042289,-0.0106980605,0.026379308,0.06242741,-0.039029416,0.047741357,-0.011211621,0.054491926,-0.14855626,0.05297782,-0.0031961657,-2.3541096e-08,0.05698209,-0.03243054,0.07287386,0.0016496396,0.05265589,0.019916413,-0.021713499,-0.042222947,0.013866675,0.00053919526,-0.008669501,0.105433874,0.05479734,0.025184155,0.0348261,-0.027346574,-0.09333208,-0.010511355,0.011565548,0.0057928558,-0.046455994,0.011229158,-0.06615535,-0.015097534,-0.0327331,-0.0324924,-0.03853568,-0.009124667,0.06650332,-0.09323799,0.018836826,0.057493534,0.0672884,-0.048853897,0.012899913,0.0003749052,-0.03436397,0.04368787,-0.09093363,0.088283874,-0.013759267,-0.15666132,-0.032716304,0.0013324217,0.047615632,0.058503848,0.07553117,-0.015200296,-0.06938219,-0.053675078,0.037383456,0.0017543073,0.03820145,-0.062005132,-0.05619079,-0.012146806,-0.09355783,-0.093522914,0.010414731,-0.034500506,0.06307939,-0.034773443,0.1309018,0.021894746 +1.1.1.34,The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.,384,1.0,-0.09745996,0.034086388,-0.06555679,-0.027130766,0.033754,0.0077373316,-0.046455864,-0.00075475854,-0.016352225,-0.037988435,0.016933555,-0.0007728994,-0.07517976,0.02191934,-0.022743503,0.040866405,-0.062059186,-0.02208232,-0.029117003,-0.05190829,0.016639063,0.020485824,-0.015955357,0.05587346,0.058908883,-0.016537296,0.09921173,-0.013384852,-0.068256274,-0.0917696,-0.053377587,-0.053099386,0.022171004,-0.03918648,0.018902274,0.07751044,-0.031043775,-0.11200143,-0.08432805,0.073930115,0.0771979,-0.05941389,-0.07901989,-0.06458454,-0.0577822,-0.03659921,-0.01011122,0.038110968,0.06396942,0.01660442,0.004648181,-0.08239028,-0.00097021786,0.027273364,-0.005497642,0.0034826288,-0.011400787,0.030397983,-0.053208835,-0.00392485,0.0045241253,-0.038673807,0.020954039,0.03826824,0.0035603226,-0.03256258,0.08081284,-0.10597602,-0.004709181,0.0010812619,-0.08240201,-0.10232861,0.061370254,0.009002648,0.029038949,-0.029446017,0.030058218,-0.05520946,0.060653992,-0.00016361442,0.0077643935,-0.054056954,-0.04239492,0.078228556,0.017735764,0.01069504,-0.025002427,0.0014190505,-0.015078558,0.02904629,0.05669589,-0.033656307,0.016252728,0.029767562,-0.06024683,0.08747144,0.0069857296,0.07607152,-0.02449994,-0.0033555357,-0.0058123176,0.10720812,-0.072087005,-0.068011716,-0.04787321,0.014610725,-0.025578503,0.07682666,-0.014732727,-0.016389426,0.00501125,-0.025848927,0.03320738,0.020563055,-0.020003492,0.16805534,0.010496453,-0.08664662,-0.036372963,-0.021414459,0.043755084,-0.020720718,0.04341747,0.028431715,-0.033948474,0.0417091,-0.11139413,1.7907534e-33,0.023544405,-0.011331182,0.013204657,0.019693874,-0.029156957,0.0003195735,-0.039645717,0.056593858,-0.04135046,-0.13983664,0.018166639,-0.028581386,0.051208973,-0.040138222,-0.038573835,-0.044751078,0.06458419,0.0010028152,-0.016264448,-0.014737016,0.12786868,0.010295512,-0.059930038,0.047944184,-0.010665118,0.07988333,-0.0755438,0.051132377,0.060777392,0.04671119,0.0024451925,-0.055703767,-0.048771292,0.03338618,-0.016277904,-0.045753606,-0.060800333,-0.035598107,0.0077590332,0.055347648,0.0017800082,0.017931696,-0.00032001085,-0.072071016,0.04280849,-0.0909791,-0.019507285,0.12787825,0.1147772,0.061632983,0.034130145,-0.034951184,0.1090468,-0.04766827,0.0077958154,0.04225495,-0.06569912,-0.040138207,0.006272995,-0.03173127,0.0443853,0.09951388,-0.08168126,0.09031344,-0.0043447185,0.077100515,-0.08545298,-0.031168219,-0.0537671,0.033836264,-0.025742318,0.020642161,0.06151254,0.032279804,-0.00710487,-0.049164094,0.0025209629,-0.01291775,-0.06394202,0.087928034,0.030102296,-0.001230316,-0.040586516,0.0016957943,-0.032919038,-0.019888617,0.05544294,-0.04975413,-0.008428052,0.045221,0.061614536,-0.07790389,-0.048240025,-0.015952993,-0.0073491097,-4.6214017e-33,0.12178963,-0.02759929,0.009293387,-0.10748564,-0.0060759485,0.045158636,0.10121397,0.03698989,0.042873107,-0.028005838,0.06574131,0.03598653,-0.015512859,-0.0249646,0.06524471,-0.0013823931,-0.042685896,0.02125078,-0.05735683,-0.008002214,0.021705586,0.012474917,0.016534548,0.04983578,0.03889512,-0.08449414,-0.031370938,0.08943311,0.018531641,0.012728395,-0.06637153,-0.006566359,-0.036945175,0.006066364,0.002174259,0.014816499,-0.1164364,-0.0296188,0.009619937,-0.024181776,0.005518726,0.015755499,-0.039428737,0.04315648,0.091216125,0.110594295,-0.035909716,0.07207538,-0.016897237,-0.07577989,-0.008285409,0.034967475,-0.010148275,0.04121967,-0.0007177457,0.029901814,0.012376166,0.06702392,0.03561653,-0.018674036,-0.015086028,-0.047704473,0.01306934,0.058781937,0.044656646,-0.009354102,-0.023049451,0.07734849,0.0047149216,0.05226698,0.06434825,0.05135936,-0.0067061,0.01447362,-0.037208334,-0.039452955,-0.10715881,0.027190221,-0.037414517,-0.072609596,0.035327576,0.0072977142,-0.005391605,-0.05805174,0.040133,0.005914292,-0.009341371,0.047445104,-0.01181455,0.0039104363,-0.05103102,-0.05983742,-0.11203063,0.09113766,0.0057247416,-4.1039154e-08,0.018349273,-0.04650315,0.05990426,-0.085819334,0.10053628,0.034121227,0.027925588,0.01327289,0.043477602,0.0002927078,-0.021422753,0.08444343,0.06054925,0.011091358,0.003660701,-0.020636076,-0.039014585,0.064778686,0.021530231,-0.02541217,-0.006713369,-0.06433246,-0.09209672,0.05839332,0.004080092,0.022680918,0.025725761,0.04291806,-0.034103468,-0.09602504,0.023761805,0.0036393793,0.06135171,0.030172242,-0.087190054,0.016897403,-0.06700014,0.05038201,-0.08466598,0.042688772,0.039926182,-0.04275359,0.019412141,0.026801668,0.023497049,-0.0037464907,0.046054162,-0.012489285,0.0026487124,-0.03624313,0.00083095673,-0.018159134,-0.08055331,-0.06386956,-0.06736333,-0.054640334,-0.030762058,-0.08257037,-0.03546408,-0.062434595,0.085029244,0.006395776,0.13813436,0.008062257 +1.1.1.35,"Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3-hydroxyacyl-hydrolipoate. Some enzymes act, more slowly, with NADP+. Broad specificity to acyl chain-length (cf. EC 1.1.1.211 [long-chain-3-hydroxyacyl-CoA dehydrogenase]).",384,0.99999994,-0.05106199,-0.07674246,-0.034431003,-0.011765701,0.05906442,0.06271575,-0.14281842,0.012776443,0.032743815,-0.07482244,0.025895745,0.03339417,-0.015662521,0.050409958,-0.030957274,0.088228464,-0.05461631,0.054108877,-0.027007775,-0.06019401,0.04579474,0.01946372,0.013435106,0.07022696,0.046920497,-0.011396403,0.020501073,-0.0006213527,-0.06780908,-0.08863444,0.026265826,0.039790526,0.008138633,-0.028451635,0.034406792,0.08945317,-0.034903936,0.00042977126,0.046296217,0.05580347,0.0066828504,-0.042366732,-0.0567754,0.023185054,-0.050240114,-0.059267845,-0.036396038,0.034920704,-0.0015943971,0.016573688,-0.037521176,-0.051936854,-0.034829937,0.07327862,-0.006792636,-0.010618507,0.00026863645,0.007925327,-0.052071523,0.015759377,-0.020352181,-0.046374146,0.010121165,0.062160518,0.017547278,0.010511911,0.07869026,-0.06152571,-0.020181471,-0.005537294,-0.116446,-0.08585543,-0.022219589,0.04936934,-0.055127632,-0.01657004,-0.056440063,-0.072198674,0.049506474,-0.0767891,-0.020403622,-0.004591488,0.014540126,0.10329416,0.077490464,-0.04492874,-0.039531857,-0.04368828,-0.032133706,0.028916422,-0.022192994,-0.044781595,-0.035046935,-0.006877123,-0.032117028,0.031884618,0.05949981,-0.0026146986,-0.036451172,-0.029565746,0.028648028,0.10264606,-0.0004219193,-0.034645546,0.0057392465,0.04555753,-0.024151081,0.09434961,-0.045722775,-0.0032913755,-0.021855025,-0.023543937,0.018769542,0.009575939,-0.028091231,0.11503797,-0.041051555,-0.017432394,-0.04530073,-0.010588444,0.028404504,-0.020576429,-0.018694248,0.034128584,0.0035394062,0.054537766,-0.039651677,2.2597536e-33,0.06928418,-0.0009875223,-0.029894365,0.029155264,-0.011824107,0.0087181125,-0.06519471,0.05109274,-0.0017940815,0.025221476,-0.00983942,0.0018426008,0.028701557,0.022046113,0.0042214557,-0.04790943,-0.023007598,0.03796838,0.018836664,-0.0024412917,0.012693689,0.008656393,-0.028274685,-0.03343555,0.0022949958,-0.018500391,-0.009747757,0.07635494,-0.011335835,0.018254828,0.05148008,-0.060111653,-0.08227277,0.03792976,0.0067432364,0.026887,-0.05247644,-0.06952937,0.008022011,0.12314492,-0.04306382,0.04031744,0.02881542,-0.080436744,0.025340881,-0.06335587,-0.03863907,0.10614952,-0.004432906,0.1030938,0.09295616,-0.030176023,0.0953924,-0.043399572,0.0047522914,0.016232478,-0.07884166,-0.016515864,0.011401387,0.023760537,0.014509364,0.0217617,-0.0743345,0.00067989505,-0.0010962386,0.037441753,-0.063911274,-0.03420362,-0.018833995,0.014047198,0.0034834968,0.04461509,0.0699864,0.10003428,0.047607582,-0.040944796,-0.04580943,0.01650575,0.04395565,0.03147578,-0.036271777,-0.023630444,0.050797395,0.0067639467,-0.00969858,-0.0075795446,0.036832258,-0.040641315,-0.017344642,-0.004689903,0.060731236,-0.07869494,0.0067549907,0.018327402,0.08695926,-2.7758109e-33,0.08200475,-0.07301554,0.029567733,-0.10364363,-0.01513961,0.07627253,0.031203112,0.063672885,-0.012021368,-0.03153989,0.06982351,0.06612449,-0.054634273,-0.10082441,0.084909976,-0.0019276009,-0.0009179244,0.0063156597,0.018020479,-0.013255299,0.063955285,0.039169885,0.0059817485,0.06271417,0.06315839,-0.005284708,-0.039588924,-0.026833164,0.058974106,0.09251688,-0.040249385,0.017745439,-0.013970861,-0.008252104,0.0272634,0.054139733,-0.11890191,0.060854282,-0.019196654,0.021017516,0.012367958,0.019733932,0.02625293,0.040198624,0.082149014,0.053733863,-0.13316165,-0.03360707,0.07663848,-0.0607326,-0.033314526,0.046761677,-0.014938312,0.0041762902,0.07593916,0.044048008,-0.044315144,-0.031405695,0.0412085,-0.11099669,-0.07059107,0.012946662,0.022528412,0.036997817,0.019902006,0.04468288,-0.078312285,-0.008835089,0.057637457,0.029665172,0.039554417,0.0020717313,-0.013008179,0.0005590561,-0.032056153,-0.11504018,-0.0696218,0.00056403386,-0.06854482,-0.0072444575,0.08886097,0.024652503,-0.002281846,-0.0931026,-0.06868738,-0.06092369,0.012050916,0.076832354,0.024820896,0.01480294,0.019268416,0.024038548,-0.06856766,0.0073119206,0.05039178,-4.2362643e-08,0.046758376,-0.037582908,0.12537116,-0.021207523,0.037840474,0.081368215,0.047933806,0.06282468,0.06362437,-0.04265115,-0.0040865126,0.16015477,0.09470646,0.006586892,0.013044297,-0.06594495,-0.00719451,0.012043692,-0.012984994,-0.034060057,-0.10499893,0.008410289,-0.027134523,0.049428344,0.0119214635,-0.020635074,-0.0043799896,-0.033441734,0.04920293,-0.03513842,0.009548595,0.053532965,-0.0075174114,-0.017849348,-0.051117208,-0.01462305,-0.02644451,-0.034147553,-0.05195376,0.047934193,-0.06172745,-0.07317445,-0.021909082,0.02670007,0.13528463,-0.051965248,0.022126026,-0.014784904,-0.053593285,-0.026202781,0.021764778,-0.035986427,-0.072044455,-0.08595338,-0.05324734,0.025685798,0.006060415,-0.102514274,-0.075823374,-0.1034354,-0.02488962,0.0054500126,0.20312227,-0.048176862 +1.1.1.37,"There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+); EC 1.1.1.299, malate dehydrogenase [NAD(P)+]; and EC 1.1.5.4, malate dehydrogenase (quinone).",384,1.0,0.0019457511,-0.06781884,0.0010164145,-0.07797138,0.0658699,0.0746181,-0.119620286,0.047365908,0.054103598,0.046332113,0.04169016,-0.025737837,-0.07844635,-0.012610314,0.012240038,-0.016195292,-0.0112471925,-0.08558935,0.05111865,-0.021320047,0.091361135,0.043524776,-0.035175942,-0.0012401091,0.07434996,0.005535974,0.012033345,0.043083895,-0.025989097,-0.0829962,-0.06029655,0.008464924,-0.054631986,0.015704893,-0.06427441,0.10471694,-0.062444214,-0.027819505,0.045012858,0.016311163,0.011180565,0.046164177,-0.07444234,-0.04218626,-0.005560844,-0.05162197,-0.01872954,0.04509769,-0.008581558,-0.016278267,-0.0713799,0.0036550742,-0.011072812,0.018067913,0.028036973,-0.00728072,0.027489768,0.030252768,-0.07078828,-0.034728993,-0.05205369,-0.026075749,0.0146477595,-0.032455523,-0.009648273,-0.023553215,0.092162885,-0.0955447,0.014632313,-0.10895721,-0.16136783,-0.0475173,0.0011951785,0.022832109,-0.061091423,0.0704883,-0.07446668,-0.045275584,-0.020829532,-0.0208195,0.017601611,0.028455982,-0.005481639,-0.05434272,0.01646139,-0.03763662,0.00936872,-0.00023963758,-0.0021383273,0.017321276,0.040192503,0.025875717,0.02645123,0.01878999,-0.0267736,0.040958468,0.063053936,0.08268142,0.029253827,-0.08621974,0.018909816,0.09733924,-0.019581754,0.012024367,-0.05735065,0.013011741,0.018592615,0.058109194,-0.001210304,0.0049645104,0.012351191,1.3462947e-05,0.05715645,0.025691546,-0.04034705,0.10398715,0.012255856,-0.041530054,-0.047351684,0.01194623,0.0751483,-0.050747063,0.08548973,0.020770004,-0.039858785,0.030310245,-0.11478217,3.541791e-33,0.085575655,0.020287631,0.006897276,0.014827427,0.002371114,0.01194029,-0.1403607,0.08723052,0.03222851,-0.04298693,-0.044930913,0.044469308,0.026552008,-0.008700265,0.029690946,0.003775281,-0.043865636,-0.045768213,0.038328517,0.032713614,-0.023714615,0.0757045,0.009373547,-0.03198723,0.04722343,0.031855628,0.021326376,0.06444982,-0.051127348,-0.017137054,0.04221445,-0.11734367,-0.00688076,0.03946708,0.017046805,-0.017340906,-0.05547861,-0.047578868,-0.018935287,-0.023526423,-0.011203022,0.018034397,0.04105195,-0.04397888,0.0019921663,-0.10833309,-0.00033467877,0.06265216,-0.013396773,0.025800657,0.014937884,0.02218115,0.08412156,-0.055306718,-0.00059859984,0.030720236,-0.019233273,-0.02641755,0.050747484,0.10694059,0.056998648,0.008281539,0.0044280733,0.020274479,-0.0061283135,-0.026763557,-0.122402616,-0.0496098,-0.03592281,0.054273628,-0.016173903,0.0030989784,0.060840797,0.030760547,0.0053674513,-0.03217253,-0.036219876,0.025226133,-0.004078858,0.0063581537,-0.009864383,0.03989427,-0.0093224505,-0.024089428,-0.029824555,0.046660054,0.024750758,0.0038489911,0.06960148,0.02171733,-0.014095156,-0.0062613473,0.004386868,-0.024908766,0.1052267,-4.3912072e-33,0.064421505,-0.05172237,-0.013225136,-0.09406629,0.013301258,0.14332023,0.07060978,-0.100916505,0.018122599,-0.049119335,0.005588795,0.024530772,0.019646075,-0.10371624,0.05093221,-0.046236254,-0.017941201,0.03512704,-0.024022613,-0.001448143,0.03305447,0.14359449,-0.034281597,-0.01977335,0.03429737,-0.004278804,-0.05249934,0.06557425,0.02703001,0.04388987,-0.0045440355,0.06650806,-0.0010870943,-0.0413569,-0.026986117,0.023604605,-0.08630024,-0.004620077,0.021501752,0.07777619,0.017338315,0.039823804,0.041043304,-0.017723303,0.07666351,0.035646208,-0.08983576,-0.10495263,0.06529096,-0.02070143,0.05091504,0.028639594,-0.08688142,-0.0025572283,0.09005595,0.060845744,-0.043918196,0.03652555,0.031045653,-0.040641174,-0.041180275,-0.021972131,0.05773321,-0.039741114,-0.027125873,0.0036568753,-0.026353447,0.040146023,0.06499883,0.030567069,0.022345506,0.006909764,-0.057787515,-0.006039422,-0.0025795095,-0.009149138,-0.107779115,0.048450418,-0.05013134,-0.03967201,0.071544155,0.015254332,-0.040684916,-0.06413047,-0.03299992,0.0035566622,0.012360133,0.06157866,-0.054577705,-0.0030033118,-0.026592987,-0.031523764,-0.048110113,0.11507628,0.039394274,-4.2161897e-08,0.02679663,-0.016139714,0.09167085,0.020832801,-0.025358459,-0.006749879,0.03369713,-0.013457515,0.043748222,-0.041864846,-0.000825452,0.041191585,0.028937068,0.038401984,0.0253843,0.0023369167,-0.10355533,0.06284893,-0.012391797,0.024819938,-0.06030755,-0.017121583,-0.11357157,0.06846898,-0.00044587953,-0.032689128,-0.015692497,-0.021369737,-0.0026973938,-0.02877776,0.01080207,0.08304935,0.07563337,-0.10340354,-0.043136984,-0.052364744,-0.0005968053,0.032768786,-0.035435617,0.04699907,0.035287544,-0.12131853,-0.12678902,0.025432488,0.094244875,0.032753643,0.041037135,-0.037414547,-0.043616332,-0.0132401455,0.09157388,0.019323055,0.022014413,-0.044032622,-0.029347684,0.013179314,-0.002894395,-0.086569294,0.02292146,-0.065788426,0.074872136,-0.046597593,0.182608,-0.015795195 +1.1.1.38,"Unlike EC 1.1.1.39, malate dehydrogenase (decarboxylating), this enzyme can also decarboxylate oxaloacetate. cf. EC 1.1.1.40, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+).",384,0.99999994,-0.033544656,-0.025607927,0.026685936,-0.033505674,0.050453063,0.024636839,-0.09721287,0.032017883,0.036584992,-0.020448182,0.022910034,-0.015091223,-0.08518254,-0.020949487,-0.023925586,-0.0011102842,0.0062881,-0.010652856,0.0446433,-0.012107416,0.06144819,0.069602795,-0.043851417,0.01353673,0.11294057,0.03249827,0.029062882,0.039705615,-0.03703048,-0.13667707,-0.003528124,-0.034779627,0.010700839,0.030849015,-0.08804154,0.10625351,-0.058687326,-0.090375766,0.032091692,0.04755108,-0.006400383,0.039298836,-0.064670056,-0.08723179,0.018536728,-0.056689985,-0.047170203,0.056734327,0.0009347968,-0.01725918,-0.0072826836,0.003945131,-0.017682077,0.032972306,0.029070957,-0.035744015,0.024906201,-0.0076487176,-0.092399135,-0.05180449,-0.019805556,0.018633092,0.043133076,-0.008455335,0.042682454,-0.022214962,0.09399207,-0.06675098,0.030791175,-0.07253781,-0.1602741,-0.07659723,0.010301676,0.06030127,-0.06702337,0.06830795,-0.06478764,-0.057509862,0.060130976,0.014611865,0.024950575,0.026588121,0.0057772356,-0.06424088,-0.00036999077,-0.020341221,0.016299276,0.044601362,0.025925517,0.018850844,0.007166637,-0.012802814,0.022149315,0.07274057,-0.051668424,0.0161349,0.03122605,0.12683046,-0.019377798,-0.0456281,0.0060435836,0.08768955,-0.02837547,-0.03971982,-0.050531182,-0.020729464,0.022226501,-0.0023137387,-0.01988434,-0.026876744,-0.03163907,-0.05974657,0.051160254,0.039384343,-0.03990153,0.076818034,-0.026693279,-0.05033334,-0.013797972,-0.030283885,0.06263807,-0.067116216,0.029592693,0.05498701,-0.0024592073,0.02321155,-0.1362814,1.9800181e-33,0.05213464,-0.0013539843,0.034147095,3.8311577e-05,0.031896036,0.0103334775,-0.09153769,0.08730908,-0.04343917,-0.057418045,-0.064935416,0.027703691,0.0377899,-0.0021357918,0.027915308,-0.033248108,-0.043661002,-0.0014109663,0.018833755,0.006628485,-0.04276659,0.0579079,-0.040451903,-0.02792942,0.043667495,0.00544022,-0.009915086,0.028470274,0.009045872,-0.00080079294,0.0100305285,-0.089436084,-0.039123077,0.057414636,0.024003195,-0.022677623,-0.025979765,-0.07188378,-0.0074722944,-0.009651227,0.021446532,0.031098275,0.015707392,-0.0336284,0.016283803,-0.0647992,-0.055404216,0.06818329,-0.009809065,0.015290033,0.0049496465,0.04283313,0.034698263,-0.10745171,0.023224916,0.046285648,-0.05040666,0.03914635,0.057676014,0.09115139,0.009428348,0.004577398,-0.0035250732,-0.016900565,-0.004524278,-0.008303724,-0.09840822,-0.019288212,-0.0006561889,0.047332995,-0.028375376,0.019728784,0.08112358,0.07612165,0.009023801,-0.047530014,3.7734746e-05,0.042458955,0.01000931,0.007897002,-0.045657642,0.019499244,-0.07883721,-0.048752073,0.004938277,0.043730345,0.0353192,0.032700233,0.061653584,0.06736553,-0.0018960545,-0.019266866,-0.037037663,-0.014468407,0.09003768,-3.4904082e-33,0.070328236,-0.0776476,-0.026318923,-0.03981627,0.007391511,0.09556771,0.06140021,-0.069558606,0.05517198,-0.023472648,0.057870492,0.0020170142,0.06450332,-0.107818715,0.05694243,-0.030744934,-0.03380552,0.026929546,-0.05062182,0.026377225,0.013124352,0.09190649,-0.015042472,-0.027190095,0.021672012,-0.0129651325,-0.06463149,0.0976788,0.048950844,0.011687814,-0.021391492,0.08034163,0.0053013023,-0.066240154,-0.07697763,0.032467965,-0.025967008,-0.030227546,0.029985217,0.053540584,0.005391206,0.037690636,-0.039727744,0.03519119,0.09466048,0.03470271,-0.06869026,-0.06265288,0.098047175,-0.075635016,0.023199078,0.045304127,-0.033019096,0.021000892,0.05310744,0.061387055,-0.042104233,0.051466126,0.030431388,-0.016564628,-0.053205352,-0.025136694,0.0875894,-0.049254626,-0.0065321056,-0.00802318,-0.051436994,0.016394043,0.05608801,-0.023351073,0.08232793,-0.0026008664,-0.049564324,0.021990882,0.022518998,-0.091949336,-0.11140045,0.038689163,-0.044153716,-0.078911975,0.04727482,0.0094268955,-0.018326296,-0.05413161,0.025271282,0.00024307368,0.0039204992,0.09952041,-0.0875425,0.032365188,-0.047663007,-0.02204657,-0.07281174,0.10127691,0.020353822,-3.4164948e-08,0.013717726,-0.039602526,0.07823655,-0.015731456,0.034695398,0.046632625,0.024545617,-0.011386326,0.011280763,-0.06567948,0.010004601,0.060061004,-0.004557379,0.03191307,0.016501008,0.010161364,-0.07354315,0.08007489,-0.0015583071,0.048429355,-0.0087952735,0.017727723,-0.06400621,0.06434437,0.0043988735,0.007348764,0.007853781,-0.013079453,0.038970534,-0.047776483,-0.023601295,0.08998762,0.10517143,-0.10060029,-0.0309538,-0.055298053,-0.008990033,-0.007502313,-0.066590294,0.033028927,0.050582554,-0.12126039,-0.09057726,0.006107948,0.056147326,0.026471004,0.077149116,-0.05293161,-0.06938559,-0.06512191,0.11082607,-0.0011903888,0.018812051,-0.054981057,-0.019557599,0.03648964,-0.02871906,-0.09628007,0.008831818,-0.028220214,0.034445822,-0.057466727,0.20635249,-0.01353142 +1.1.1.39,"There are several forms of malate dehydrogenases that differ in their use of substrates and cofactors. This particular form is found only in the plant kingdom. Unlike EC 1.1.1.38, which catalyses a similar reaction, this enzyme can not bind oxaloacetate, and thus does not decarboxylate exogeneously-added oxaloacetate. cf. EC 1.1.1.37, malate dehydrogenase; EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating); and EC 1.1.1.83, D-malate dehydrogenase (decarboxylating).",384,1.0,-0.0106197735,-0.08667233,0.0053866324,-0.06014961,0.080164395,0.053178083,-0.118241556,0.01595338,0.042568058,0.008563273,0.088761054,-0.054000955,-0.07316881,-0.06575616,-0.02198642,-0.028235767,-0.020123037,-0.076482706,0.037903037,-0.039710436,0.0804937,0.068792105,-0.0545574,0.01876288,0.08549364,-0.0050676297,0.0018781584,0.020370517,-0.0053939247,-0.12966609,-0.032127414,-0.0042097857,0.027614594,0.050534,-0.07878809,0.08493034,-0.019805886,-0.076237835,0.07335465,0.026231391,-0.008399893,0.045785885,-0.031622704,-0.09033764,-0.02861547,-0.045416825,-0.053272404,0.03509885,-0.008237186,-0.04481048,-0.019747416,-0.01171343,0.002337554,0.0075858054,0.021050949,-0.007429617,0.037907425,0.05004229,-0.08152875,0.0020540482,-0.006908384,0.015372002,0.04672316,-0.03657348,0.0028805253,-0.02774184,0.03267512,-0.07992743,0.04919411,-0.07709193,-0.11413681,-0.071092576,-0.016487196,0.038931467,-0.0910383,0.0897252,-0.07436049,-0.047926247,-0.018710913,-0.04645929,0.034692317,0.0438842,0.046651557,-0.075240046,-0.02642947,-0.044898514,-0.01759829,0.031112347,0.066586785,0.021842359,0.077838965,0.0025589147,0.004750329,0.040231206,-0.0066300347,0.04343412,0.07775314,0.12874539,0.016093876,-0.07088579,0.0017107571,0.049912516,-0.042092178,0.013914708,-0.053501446,0.0039482284,-0.016997904,-0.007736138,-0.013527598,-0.011248507,-0.015986988,-0.03564901,0.06656514,0.06752009,-0.059190705,0.07167672,0.036427744,-0.069193155,-0.021386588,-0.0300583,0.080188505,-0.06314444,0.07493368,0.044775113,-0.015427437,0.04421288,-0.15401188,1.9000828e-33,0.077891715,0.0027648853,0.0033356259,0.010363489,-0.002095606,-0.02067355,-0.08116748,0.09105551,0.0028490135,-0.0635049,-0.06370772,0.07724677,0.022615189,-0.013229052,0.01871823,-0.008629462,-0.027620403,-0.007548877,0.016632611,0.04786287,-0.032316376,0.048159264,-0.051275164,-0.035203427,0.024438301,0.021412337,0.033459343,0.01055502,-0.012097474,-0.017379126,0.0024741655,-0.119077116,0.038535737,0.06969676,0.030263565,-0.018596549,-0.04792308,-0.062549904,-0.015832359,-0.026034765,0.075847216,0.035194337,0.022786425,-0.041020405,0.0024063175,-0.05815373,-0.04610747,0.066038586,-0.009936027,0.04285218,-0.0034051905,0.056480065,0.065387174,-0.070349485,0.030466033,0.034624234,-0.052090783,0.007536892,0.092614055,0.09462802,-0.015641678,0.0027968069,-0.0073606702,8.528653e-05,0.04073864,-0.009013178,-0.12278163,-0.016445564,-0.037918404,0.053093985,-0.032377366,-0.016781854,0.02851159,0.070927255,0.018012527,-0.04863552,-0.040625572,0.060564015,-0.016693205,-0.00021972046,-0.011696777,0.074576475,-0.068190426,-0.029224606,-0.016484315,0.03828004,-0.0119619565,0.025503533,0.03906363,0.05220772,-0.018801993,-0.005656694,-0.03504438,0.017257608,0.11343638,-3.605245e-33,0.075692646,-0.06481643,-0.0170538,-0.06408952,0.001418099,0.14149863,0.04319559,-0.07830946,0.075970516,-0.0035635985,0.021854948,0.048056163,0.04172148,-0.088241205,0.03126256,-0.034603223,-0.0052982015,0.05954518,-0.057015534,-0.0058704247,0.014176176,0.08342434,-0.017847309,0.0050185225,0.026915774,-0.007543523,-0.061855737,0.07652532,-0.0018653258,0.027616005,-0.0055361716,0.06720659,0.010532195,-0.043017104,-0.0904492,0.011908663,-0.06440796,-0.021879217,0.038597412,0.05506439,-0.021566596,0.036960155,0.032662895,0.022144359,0.089766786,0.024295932,-0.062187713,-0.06974836,0.078008436,-0.014772044,0.026831023,-0.0024669298,-0.043891903,0.006772138,0.050753355,0.062311593,-0.0028044472,0.07998191,-0.025338903,-0.020951614,-0.022325885,0.009934721,0.034665953,-0.05220926,-0.041946433,0.0058303913,-0.02061521,0.0606068,0.06303495,-0.014661295,0.04556424,0.0071904953,-0.051092945,-0.0006060429,0.014324523,-0.00991033,-0.091173455,0.015823012,-0.05829928,-0.06440164,0.030005002,0.023266884,-0.018728243,-0.06350229,0.0013002408,0.0020158782,0.012468863,0.074975036,-0.07030496,0.034459617,-0.05699651,-0.06806474,-0.055610258,0.102518916,0.06374741,-3.9350617e-08,0.0019731803,-0.015513364,0.076107465,-0.018684926,-0.0103401365,0.02250315,0.026453346,0.0031288571,0.022671973,-0.06899672,-0.025168594,0.02996421,0.007837921,0.062525585,0.008515084,-0.008295931,-0.08914743,0.049823407,-0.024369268,0.08500355,-0.009362364,-0.01683864,-0.089733794,0.057865642,-0.024428867,-0.025912087,0.029772133,0.011185093,-0.0067533804,-0.018073233,0.021828879,0.09719381,0.05380085,-0.091031075,-0.02207747,-0.09944735,0.0026796157,-0.011324159,-0.044830184,0.04432534,0.051331855,-0.08735275,-0.091179416,-0.000896481,0.068841554,0.029773923,0.008718084,-0.013778159,-0.040711403,-0.0046109264,0.099785484,0.009683088,0.011005967,-0.058680344,-0.027528351,-0.0113455625,-0.009442177,-0.08694114,0.042611375,-0.037224054,0.03179878,-0.06723974,0.21076716,0.012885911 +1.1.1.40,"The enzyme catalyses the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and the decarboxylation of oxaloacetate. cf. EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), and EC 1.1.1.39, malate dehydrogenase (decarboxylating).",384,1.0,0.010429983,-0.009743011,-0.0020096628,0.00466195,0.06593428,0.08457673,-0.0690635,0.009799077,0.034052063,0.02272284,0.0051249824,0.0061596627,-0.047578923,-0.060265873,-0.06091097,-0.013961576,-0.041493926,0.0020324169,0.007886978,-0.010645352,0.10139822,0.03186123,-0.030699743,-0.011018414,0.117721416,0.040358316,0.043851618,-0.068007834,-0.060178805,-0.08825287,-0.03115767,-0.050208364,0.020404864,0.026426835,-0.077872224,0.0885247,-0.042100657,-0.06084928,0.04670538,-0.006372719,-0.01784579,0.035021223,-0.053952552,-0.08373552,0.009730956,-0.07877611,-0.031183733,0.023278654,0.008825287,-0.0042800196,-0.018091286,-0.0028386328,-0.007316921,0.04305549,0.0031433613,-0.014506585,0.046910837,-0.028574623,-0.090228654,-0.027363129,0.022696529,-0.006193959,0.0141622005,-0.0015500337,0.042416748,-0.05393787,0.061388697,-0.031405356,0.015551821,-0.10884016,-0.12635711,-0.07698,-0.036493458,0.005418782,-0.05453587,0.038598347,-0.038460445,-0.047273587,0.04844599,0.021144412,0.06035918,0.055180423,0.056724813,0.0021666249,0.03928905,0.008340287,-0.035788182,0.07415367,0.06923469,0.053794663,0.021717371,-0.03516593,-0.010092095,0.057169963,-0.06253761,0.013467225,0.057684094,0.088008046,-0.008695396,-0.026306735,0.03735701,0.069402024,-0.0040808227,-0.08143545,-0.029481553,0.034950662,-0.015080569,0.014212905,-0.00969347,-0.010096183,0.0010807397,-0.020939894,0.041896936,0.0917648,-0.03646632,0.13334392,0.015368551,-0.03870908,-0.06951599,-0.056313176,0.05855615,-0.013133272,0.0026538854,0.023661971,0.010699945,0.03291115,-0.124105185,2.6591073e-33,0.047437344,0.008440907,0.027720377,0.03394251,0.044341534,-0.025395423,-0.07693162,0.066241175,-0.020040609,-0.00821121,-0.087915696,-0.009534447,0.026579758,-0.051285595,0.037049517,-0.026600206,-0.033764075,-0.025729,0.03085232,-7.814235e-05,-0.055835374,0.043653667,-0.030056812,-0.04512223,0.03938012,0.058080744,-0.010147952,0.011960771,0.005549503,0.0034125778,0.039958425,-0.09359923,-0.01421007,0.0320275,0.052099388,-0.0058720037,-0.042774834,-0.048291408,-0.014521934,0.016753245,0.04277881,0.01095449,-0.022310345,-0.0058195405,-0.0067972215,-0.096452914,-0.055270646,0.08763675,0.020625306,0.033291325,-0.0007566622,0.022465965,0.05823508,-0.05751833,-0.0042527113,0.07522992,-0.0748185,-0.0136596095,0.08415005,0.08233572,0.020729808,-0.06750247,-0.007503484,-0.008425806,0.02603061,-0.011307462,-0.09601669,-0.015187956,-0.016942192,0.055549737,-0.05346955,0.011528407,0.0723092,0.06604818,-0.0055819224,-0.023029689,-0.008997398,0.026949707,0.0524765,-0.003343719,-0.0037353856,0.03187807,-0.07563768,-0.034959927,0.006046633,0.034792524,-0.00736576,-0.010551449,0.020317825,0.025402565,-0.011633368,0.01727471,-0.058417473,-0.006189667,0.06725132,-4.2593615e-33,0.1074627,-0.10257163,-0.018884042,-0.05696908,0.015995864,0.07096747,0.032278497,-0.09378071,0.015039608,-0.0142315775,0.0114901345,0.0073635257,0.04578161,-0.09364065,0.051766578,-0.016656702,0.028128186,0.054330397,-0.029813057,-0.025973309,0.039064437,0.1017006,-0.004416615,-0.064771146,0.0089960545,-0.03298714,-0.05456473,0.055024657,0.052438423,0.08417948,0.043420617,0.03421315,0.00035307172,-0.08247261,-0.05880323,0.049532644,-0.016529022,-0.005476711,0.057744343,0.119878806,0.0054199984,0.015484045,-0.033074677,0.049216624,0.12598361,0.030192664,-0.11335543,-0.051836953,0.082256325,-0.10466781,0.08801825,0.004790382,-0.021578593,0.014085894,0.0676519,0.08018494,-0.03909179,0.012943471,0.032086346,-0.036171813,-0.064147785,-0.004492414,0.066693895,-0.058041535,-0.03991479,-0.007686864,-0.025204716,0.0345078,0.056929022,-0.073901094,0.05849041,0.020909665,-0.045996062,0.028038206,0.013352537,-0.083647676,-0.12119005,0.011631102,-0.015371276,-0.06687273,0.024797762,0.032800518,0.0016512778,-0.09613665,0.0018323665,-0.063350216,0.03235459,0.13487484,-0.08247473,0.006677399,-0.062493686,-0.034251742,-0.054285284,0.10416015,0.029296733,-3.75069e-08,-0.015326031,-0.00931882,0.042940345,-0.017820911,-0.024592608,0.10333527,0.055434052,0.005327778,0.0062816287,-0.10938236,0.01844639,0.050220877,-0.025017383,0.05540398,0.028562164,0.012920338,-0.07663487,0.09320686,-0.03648606,0.015327631,0.033839278,0.020807123,-0.056081053,0.04044389,0.003580838,-3.1424268e-05,0.01737325,-0.0047205384,-0.014675641,-0.022152308,-0.031147523,0.10532147,0.06726715,-0.07821384,-0.050172508,-0.067132294,-0.010366557,-0.03847752,0.013206399,-0.007814007,0.005659223,-0.08227443,-0.091355436,0.0057458384,0.02887146,0.038532287,0.041943535,0.029340936,-0.07452523,-0.014366352,0.12564635,-0.013278255,-0.022368008,-0.029997379,-0.031001126,0.021810029,0.006803103,-0.09267108,-0.025043646,-0.07534483,0.020244632,-0.033150416,0.17152706,-0.054906834 +1.1.1.41,"Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [7]. The enzyme from some species can also use NADP+ but much more slowly [9].",384,1.0,-0.07064372,-0.014836505,-0.06702831,0.02047911,0.04964458,-0.02889262,-0.13628599,-0.0056292703,-0.002996908,-0.03475038,0.07747141,-0.031006066,-0.038610134,0.0106565235,-0.0024907156,0.0029391397,0.02711041,0.009333538,0.08580742,0.012379069,0.031234423,-0.010813615,-9.291948e-05,-0.043199558,0.10368002,0.018421667,-0.008074878,0.040931337,-0.05513887,-0.07424225,-0.028324358,-0.049598094,0.042481165,-0.07646241,-0.013355233,0.09697171,-0.041678574,-0.026977079,0.013591401,-0.016512439,-0.004453048,0.009748878,-0.01599907,0.02118638,-0.045339588,-0.10728301,0.027702669,-0.0018411111,-0.021363454,0.0105137555,-0.065819874,-0.010587234,-0.0023380446,0.014727118,0.017971499,-0.06060052,0.003847642,0.01121955,-0.087680705,-0.05343134,-0.023860034,-0.07207112,-0.005082658,-0.008654828,0.048053067,-0.029501332,0.062335227,-0.062686406,-0.0064888173,-0.014490681,-0.080182835,-0.039784756,0.020157902,0.08735161,-0.07663015,0.09275774,-0.032128427,-0.061381444,0.051432647,0.012156495,-0.010824568,0.016512562,-0.018844226,0.021504454,0.058483053,0.031039868,0.039666045,-0.012062633,-0.053295966,0.04547764,0.022443065,0.073016234,-0.031191291,0.028929884,-0.11899925,0.03296379,0.045554355,0.10694473,-0.043142796,-0.06349642,0.07320028,0.11592565,-0.054605544,-0.025378995,-0.022411918,-0.033224568,0.005948928,0.051857915,0.0022678568,0.059056345,0.04076019,-0.008176318,-0.03389346,0.015390504,0.0032409353,0.07949327,0.0049401047,-0.081658885,-0.07546477,-0.024445597,-0.003170761,-0.048925284,0.00304607,-0.0075588333,-0.010067996,-0.014471715,-0.07264947,3.7185405e-33,0.06701401,0.009042441,-0.03196251,-0.007821664,-0.026512174,0.018669792,-0.07187099,0.03426363,-0.018336773,-0.055175178,-0.09892896,-0.024211774,0.034837577,0.05464334,-0.016540056,-0.018577207,-0.00048744775,-0.0445116,0.07016383,0.05566765,0.028761681,0.049452584,-0.017474374,-0.017208079,-0.0017853597,0.066684626,0.00060662243,0.02428454,-0.0006439027,0.0073718955,0.028752495,-0.14877993,-0.12982072,0.0063936454,0.087626845,-0.0037897388,-0.053633742,-0.036974277,-0.022033071,0.006759901,-0.0101684425,0.058970176,0.008069853,0.008697044,0.074364476,-0.05532531,0.010424343,0.07798184,-0.024952978,0.06272299,0.014804985,0.0047526127,0.094157666,-0.063001044,0.008783181,0.072208904,-0.02632195,0.045459535,0.0190913,0.10416623,-0.01602787,0.059947252,0.04290217,0.06333187,-0.019516584,0.05400934,-0.14790909,-0.07898156,0.036791153,0.0593638,0.06405465,-0.037093543,0.04425945,0.04318748,-0.0021406808,-0.027159147,0.036414415,0.027930543,0.039488252,0.0256502,0.0022903741,-0.066956244,-0.040826693,-0.029664204,-0.0025830553,0.06295535,0.015068567,0.01718069,0.01040039,0.06746299,0.07379648,0.022460418,-0.010052893,-0.06864776,0.044576705,-5.489295e-33,0.12141662,-0.048040595,0.03317176,-0.13253827,-0.083136596,0.10702853,-0.025437802,-0.07482379,-0.008123998,-0.017957447,0.054408107,0.016308028,0.017699463,-0.04411692,0.00034508802,-0.022313092,-0.024615254,0.06325527,-0.0048253867,0.009314856,-0.036927737,0.15375403,0.036858257,0.027574543,0.047452528,-0.048667412,-0.01596835,0.0022614326,-0.017215991,-0.03706274,-0.035025854,0.06177735,-0.03925763,-0.034616552,0.012759232,0.039690368,-0.06155904,-0.039875716,0.006963388,0.06539599,-0.03866301,0.040999163,-0.040169522,0.02571637,0.025490299,-0.03880951,-0.1263156,-0.026523268,0.01841088,-0.020184105,0.046408106,0.009723349,-0.08464793,-0.041425165,0.081914485,0.0027014532,-0.047896158,0.06002162,0.073581874,-0.04085084,-0.030782394,-0.030236786,0.039342735,-0.016554607,0.036822382,0.045668263,0.022693176,-0.0029643294,-0.024516335,0.05435157,0.04484498,0.023284124,0.022890814,0.0020441918,-0.0013276228,0.0025385732,-0.034942146,0.05109751,-0.05862207,-0.045398448,0.030922836,0.0032958006,-0.007620901,-0.07452021,-0.030964648,-0.05645068,0.022392893,0.033717547,-0.06686957,0.04071469,0.028761262,-0.03899364,-0.06760422,0.08749532,0.021201763,-4.4229786e-08,-0.007369825,-0.006436223,0.0749728,-0.05678009,-0.0057308935,0.05596324,0.0025415956,-0.09327392,0.0795208,0.012818355,0.04748206,0.120293655,0.033251688,0.03562887,0.032364532,-0.04532787,0.023608318,0.05908646,-0.029947987,0.05918383,-0.043954782,-0.017042441,-0.14069022,0.08148416,0.09605379,0.0019159862,-0.0046155164,-0.062200177,0.06165133,-0.076707296,0.004317326,0.0023291914,0.061205547,-0.056674603,-0.03755483,0.017117247,-0.036209792,0.023681568,-0.095778085,0.052592013,-0.04591461,-0.10697433,-0.020675767,0.011685554,-0.01477954,-0.014235027,0.0017135337,-0.00012191457,-0.0853934,0.02389219,0.018664632,-0.061691154,0.017274726,-0.09766348,-0.045618977,0.06568955,0.01180429,-0.067893356,-0.0888876,-0.0053465953,0.079462245,-0.011563369,0.13073854,-0.02651913 +1.1.1.42,"Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [6]. The enzyme from some species can also use NAD+ but much more slowly [6,7].",384,0.99999994,-0.07002034,-0.015872715,-0.08176204,0.023850365,0.04317099,-0.021884497,-0.1338306,-0.011080404,0.009926854,-0.018894082,0.083558574,-0.028660672,-0.042680748,0.007833206,-0.0046326425,-0.0012615003,0.015616283,0.02008558,0.08402059,-0.00021812305,0.041114207,-0.0044307653,0.0044165254,-0.04128712,0.098749146,0.008590326,-0.022167483,0.033095893,-0.038365483,-0.08321498,-0.017850708,-0.058494005,0.05931782,-0.06245746,-0.023499066,0.09181509,-0.047203254,-0.02102247,0.016537083,-0.004290348,-0.0069586397,-0.0015314113,-0.0012478987,0.018867582,-0.049540363,-0.104116626,0.032743018,-0.0051432448,-0.003294581,0.028955584,-0.05738525,-0.020929348,-0.01942606,0.013697727,0.037502218,-0.055319235,0.0017924616,0.01111676,-0.08769022,-0.050595827,-0.011990893,-0.07102794,-0.018876918,-0.0064548245,0.044585433,-0.04088794,0.0699095,-0.054498106,0.008454328,-0.032923706,-0.07326191,-0.033143196,0.02199946,0.08026506,-0.076645665,0.09065374,-0.0512493,-0.061760355,0.03620319,0.009617302,-0.0008894893,0.017364623,-0.026025636,0.02412234,0.060207855,0.03539453,0.039884795,-0.0148358755,-0.05040572,0.035078187,0.028369859,0.082581595,-0.037674762,0.02285337,-0.11992756,0.030269885,0.05466758,0.11420288,-0.023963694,-0.06642961,0.07407182,0.117639676,-0.059001274,-0.014193865,-0.015409396,-0.025275059,0.0019203007,0.06769475,-0.0070971134,0.064657606,0.03928623,-0.0067726765,-0.033771574,0.02310331,-0.010725015,0.07851251,0.019107874,-0.08468159,-0.07213626,-0.027213885,0.0057956954,-0.032949325,0.0012177138,-0.013764593,-0.012706409,-0.003924989,-0.07523469,3.2073036e-33,0.06491458,0.020867588,-0.033727583,0.009539025,-0.03633882,0.029705605,-0.07099641,0.036555246,-0.021140594,-0.041826535,-0.09903411,-0.003176885,0.037289195,0.06756826,-0.009592534,-0.030731086,0.006968396,-0.051070917,0.06297884,0.062344845,0.030720087,0.04797928,-0.016750127,-0.011002989,0.010226352,0.058678906,0.012552673,0.015054429,-9.670359e-05,0.0068552988,0.015580828,-0.1615507,-0.12141375,-0.003595558,0.090978615,-0.011409361,-0.056624398,-0.018495988,-0.024141291,0.007969535,-0.027321434,0.044380948,0.0033590442,-0.0019600259,0.067190684,-0.062305093,0.0154231135,0.07274473,-0.02539777,0.06725402,0.015250945,-0.008560532,0.09635226,-0.056011986,-0.0056209825,0.07418426,-0.020278148,0.04483238,0.016676541,0.11244044,-0.01806591,0.061520513,0.03996207,0.07060401,-0.011769418,0.035671797,-0.14861175,-0.081380494,0.025727052,0.063804716,0.058172986,-0.04376813,0.041759904,0.03712031,-5.3511212e-05,-0.021071691,0.018142372,0.012997745,0.030093772,0.0065260963,0.0062295473,-0.05357901,-0.039731428,-0.019003486,-0.014815611,0.059845928,0.0026510481,0.0049328543,0.00074983836,0.064397715,0.063931584,0.005330539,-0.0076232553,-0.08193576,0.043795664,-5.0711528e-33,0.12821737,-0.043159567,0.040518176,-0.13958476,-0.0790842,0.124102876,-0.023252206,-0.067280985,-0.006430587,-0.016473817,0.048717108,0.03005086,0.013389623,-0.047482587,0.001974455,-0.028790526,-0.026621329,0.053405613,-0.0036120852,0.005252542,-0.029920243,0.1621399,0.037762973,0.011433324,0.04864315,-0.047622137,-0.011132529,0.012698018,-0.020088566,-0.02508265,-0.0469565,0.044127524,-0.0120903,-0.040482596,0.005364816,0.046644058,-0.04907343,-0.044632602,0.003641507,0.068317704,-0.038821824,0.035034962,-0.025357585,0.027675906,0.037252728,-0.029631445,-0.14032458,-0.023525046,0.018627366,-0.024898423,0.05519604,-0.004469696,-0.07938086,-0.0333351,0.08794896,-0.012335456,-0.054666385,0.05244264,0.0711532,-0.033439554,-0.027536863,-0.036753565,0.039636027,-0.025194231,0.020775666,0.03411253,0.019216929,0.00072422967,-0.028839882,0.060416415,0.062009588,0.03477553,0.012446773,0.008026373,-0.0043081464,-0.013147918,-0.040508233,0.03804022,-0.061330207,-0.03427129,0.023837939,-0.0054700826,-0.007332993,-0.0751642,-0.019259013,-0.055050317,0.020818874,0.028490927,-0.07941643,0.044800468,0.01699498,-0.0396571,-0.07708537,0.09270487,0.009625418,-4.4878227e-08,-0.0061887978,-0.01716747,0.0729919,-0.057102606,-0.0057444647,0.05954574,0.007824311,-0.072455004,0.07072487,0.0043364377,0.05210463,0.11793333,0.042166118,0.04052899,0.02793995,-0.023528203,0.020010533,0.05342473,-0.03854833,0.06121061,-0.03837006,-0.007922808,-0.14793329,0.07730611,0.09243103,-0.0005351473,0.017924068,-0.054036565,0.048268713,-0.078281656,0.0058213295,0.0034570238,0.057410948,-0.051052302,-0.04640223,0.020016305,-0.026830625,0.024282822,-0.08494496,0.05371216,-0.037012283,-0.10111341,-0.039905958,0.01562031,-0.013063352,-0.01797931,-0.010422568,0.0071745007,-0.07877696,0.021470645,0.013655448,-0.054161727,0.011260911,-0.08404194,-0.066409916,0.069407165,0.0017441515,-0.06970052,-0.07919692,-0.01403449,0.10158469,-0.010834903,0.14295267,-0.02118398 +1.1.1.44,"The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).",384,1.0,-0.04909623,0.009555289,-0.027458427,-0.047250055,0.03412682,0.024226746,-0.04191014,0.0011192752,0.07546023,0.021878231,-0.034341153,0.0544539,-0.11849183,0.026877793,-0.04613922,0.0061413306,-0.06342704,-0.0018498685,0.015996782,-0.029392496,0.13544507,-0.0021070326,0.011472026,-0.07576217,0.07832095,0.023742367,0.05240297,-0.011749107,-0.017004358,-0.06593169,-0.0169109,-0.02945832,0.026298892,-0.07635548,0.008773459,0.111447364,-0.037614323,-0.036373768,0.006164028,0.023281267,0.016039649,0.011221068,-0.04846396,-0.010782369,-0.015327818,-0.06566043,-0.014006574,0.08750039,-0.02518797,0.023528494,-0.024346795,-0.012575554,0.039682735,0.0050557177,0.037354127,0.00090242946,0.070775345,-0.013176651,-0.084991,-0.10792383,0.014257886,-0.04570348,-0.02180789,0.02358327,0.03932929,-0.11055983,0.07774815,-0.021539707,-0.017738074,-0.08911493,-0.09860083,-0.022323936,0.018003281,-0.035915602,-0.013331121,0.04703955,-0.056499418,-0.010182208,0.036848918,0.03704423,0.11834543,0.033956364,-9.021063e-06,0.10368249,0.086716264,-0.012966529,-0.0034513676,0.017480921,-0.004681661,0.0038466388,-0.041195694,-0.059484944,-0.01475902,0.058733765,-0.13950033,0.027411345,0.027789226,0.032074943,-0.004792652,-0.0668682,0.039276585,0.09310105,0.018953072,-0.06382266,0.001758622,0.04049883,-0.06092385,0.09234565,-0.0194161,0.01593203,0.0024423047,-0.007976292,0.039635383,0.005083553,0.024976324,0.07787785,-0.05351057,-0.045240406,-0.020992465,-0.013014769,0.0053272867,-0.0032057234,-0.037555914,0.07536715,-0.01803329,0.05618903,-0.12278526,3.0902948e-34,0.09066191,0.02748655,-0.012964863,-0.026145902,0.03949694,0.038690027,-0.08467867,-0.0016347318,-0.07851732,-0.021767179,-0.03746163,-0.059167225,0.08021004,-0.018181967,-0.021921411,-0.0039450997,-0.065424174,0.007992368,0.03470419,0.08859821,0.015048678,0.03824228,-0.08307976,0.03881539,0.03708481,0.06694454,-0.08931166,0.05030665,-0.040348884,-0.006714397,0.08252727,-0.07421979,-0.102312334,-0.042647503,0.07126031,-0.05428302,-0.040799886,-0.07111748,-0.018200288,0.048389774,-0.022198549,0.0046489285,0.0047843796,-0.009497093,0.04346462,-0.053855177,-0.048870817,0.048280697,0.066081956,0.062160242,0.009940917,-0.011325466,0.11299646,-0.03665521,-0.025794098,0.0068789027,-0.07379667,-0.059450176,0.025897155,0.06805204,0.01767946,0.006796066,-0.08986033,0.048603956,-0.0423801,0.013884111,-0.008860963,-0.07209602,0.03554607,0.08915901,-0.091922574,0.0014759415,0.050564848,0.0077119344,-0.007957557,-0.01987662,0.014625551,0.037502527,0.02761706,0.029168528,0.028652893,-0.033991832,-0.06859256,-0.055509165,-0.013516659,-0.02748666,-0.005453966,-0.050307956,-0.009464895,0.023797765,0.03412166,-0.0065899133,-0.050204087,0.014577778,0.042578343,-2.7744738e-33,0.12160122,-0.06428081,0.026249643,-0.10471455,-0.049840067,0.08374011,0.026772793,-0.12888919,0.03283092,-0.02733807,-0.003958557,0.0028873074,0.051713202,-0.006294839,0.010752035,-0.020635717,-0.046531275,0.049956273,0.011317074,-0.021447197,0.040854946,0.16128361,0.032158148,-0.013008263,0.055041686,-0.05502475,-0.06879336,0.003866299,0.011427395,0.054715812,-0.001918659,-0.009409106,-0.053951677,-0.01625492,-0.052283328,0.031340335,-0.10125139,0.0052205734,0.07409407,0.10245375,0.030633494,0.0067960965,-0.029890046,0.019882133,0.028974906,0.024119139,-0.13065562,0.042544372,0.02296168,-0.08368446,0.0327019,0.072978176,-0.0200262,0.055875205,0.058943506,0.05008452,-0.046479285,0.011174436,0.084366046,0.023992805,-0.03124116,-0.02282735,0.058268424,0.004769495,0.018619753,0.0020156594,-0.011208342,0.042712733,0.035561133,-0.012096899,-0.006032286,0.06303325,0.029250829,0.06964301,0.0070411633,-0.026745947,-0.16045363,-0.025359258,-0.02958249,-0.014221269,-0.045760356,0.021325773,-0.024013748,-0.03920301,0.01028908,-0.023893999,0.002640727,0.07903652,-0.02290011,0.00967067,-0.007457357,0.0018481747,-0.051718548,0.037425738,-0.0031118628,-3.3136313e-08,-0.011246467,0.021091506,0.029780805,-0.048734587,-0.0005291905,0.012152312,0.066171184,-0.028700124,0.04892974,0.018272262,0.032479066,0.12596685,0.0222426,0.021112084,0.066765614,0.023186537,-0.020626394,-0.0064912457,-0.009828631,-0.0031869418,-0.00059251435,-0.02070224,-0.12578489,0.0722629,0.025297023,-0.019087985,0.062738635,0.008750081,0.027429882,-0.02826946,0.0067308475,0.0288775,0.06389938,-0.039189998,-0.071756,0.028128564,-0.057790678,-0.012575312,-0.037842795,0.014485241,-0.027994782,-0.098890595,-0.03996425,-0.016373005,-0.006507063,0.068310164,0.051967233,-0.0077235666,-0.08557254,0.059708867,-0.0010169952,-0.042266198,-0.013775431,-0.017189257,-0.046701252,0.009282586,-0.014008636,-0.058883365,0.017864222,-0.025416713,0.010175131,0.05116149,0.1840189,-0.100983895 +1.1.1.45,Also oxidizes other L-3-hydroxyacids.,384,0.99999994,-0.048868757,-0.111291304,-0.019982109,0.033057272,0.07728409,-0.015599209,-0.05306661,-0.0015212334,0.030573262,-0.056656335,0.05045051,0.069261245,0.004502204,0.05158816,-0.0035696062,0.06897368,-0.066987514,0.08230628,-0.074445605,-0.017120434,0.07654819,0.006711214,0.03567071,0.05512369,0.022870064,0.031484433,0.026821787,0.007158473,-0.02255707,-0.06337512,-0.000835122,0.061053816,-0.0014468356,-0.07344311,-0.028754435,0.034560625,-0.080397226,-0.02008985,0.017935278,0.05317701,-0.0017815769,-0.07657516,0.05925094,-0.037848264,-0.014481271,-0.05138997,-0.032316253,-0.015403684,0.037345115,0.029637674,0.021077158,-0.010654244,-0.043003097,0.056519955,-0.08393706,0.0009739459,-0.082093015,0.06700876,-0.00029493746,0.0569447,-0.051877756,0.076196246,0.005406363,0.05582813,0.016533745,-0.047041908,0.004005846,-0.055085395,-0.050509583,-0.0020354874,-0.015247969,-0.08480881,0.04775985,0.03399925,0.022789985,0.021598523,0.030669814,-0.06703525,0.004918758,0.024620892,-0.0028997874,0.026938068,-0.067325145,0.17420843,0.04897478,-0.05821673,-0.08223021,-0.07014737,-0.08363382,0.022045951,-0.004677432,0.03885485,-0.034109283,0.057376277,0.0063934657,0.031067276,0.027106712,0.045157082,-0.09413555,-0.009623803,-0.03198043,0.07207137,-0.070720546,-0.060039606,-0.045177143,-0.011393128,0.03281177,0.046840426,-0.03296359,-0.036843654,0.030476928,-0.0010758605,-0.0116722165,-0.008708372,-0.10712157,0.09372896,0.064478554,-0.045909874,-0.057944123,-0.048172865,0.0068051117,-0.061846014,0.013492818,-0.04994054,-0.07610254,0.026302189,0.036682595,2.882864e-34,0.038934223,-0.0028851868,-0.016324177,0.026506538,-0.00797177,0.024333766,-0.10233824,-0.04556968,0.059584804,-0.019508941,-0.06852115,0.060057916,0.03291908,0.023080217,-0.025864283,-0.018134456,-0.05684725,0.007979221,0.047468837,-0.010708095,0.048986606,0.009418883,-0.020385452,-0.021903357,-0.005212329,0.021211825,0.057821225,-0.040898975,-0.005969404,0.004240244,0.022652788,0.009214142,-0.032174043,0.030754488,-0.04085366,0.11206626,-0.11046623,-0.0761192,0.0070068627,0.055407915,-0.0047625955,0.056535587,-0.0036242867,-0.019789152,0.014666063,-0.05172655,-0.052716054,0.07302959,0.012223766,0.052229807,0.10444305,-0.022212738,0.03383074,-0.017379533,0.011652625,0.006247806,-0.025143769,-0.043973975,0.018018153,0.04881643,-0.01786912,0.06205292,-0.03709801,0.05035194,0.0035303636,0.005011598,-0.045300607,-0.024468146,-0.037309624,-0.0072630416,-0.07540644,-0.038711727,0.12301737,0.030063178,0.01104119,-0.0055613033,-0.06869574,0.03635692,0.058231577,-0.028996728,0.06178571,-0.08588766,0.065045334,0.1038527,-0.02059971,0.0035308525,0.03351758,-0.024880499,0.046854645,-0.036374107,0.094521485,-0.09105601,0.015627518,-0.051399566,-0.014807669,-2.0009208e-33,0.0414209,-0.102049,0.009189573,-0.07725547,0.011424583,-0.02857919,0.025689833,-0.028755637,0.020207714,-0.02211162,0.053255077,0.01528106,-0.07624473,-0.08189468,0.09115016,-0.024503961,0.03233204,-0.014219643,-0.05231505,-0.018226892,0.073660515,0.061781812,0.046616793,0.06798363,0.04287598,-0.026295308,-0.032886803,-0.033736344,0.034604162,0.06487376,-0.008024428,-0.007817132,-0.039338004,-0.058199853,0.049405552,0.049548324,-0.076667786,0.010628732,0.019959811,-0.05642946,0.0040754457,-0.018711153,0.07644624,0.0645349,0.052819047,0.06814291,-0.072204,-0.08178732,-0.0070707686,0.035638817,0.007619349,-0.030055525,-0.050589036,0.006199992,0.09091015,-0.0062260334,-0.049484033,-0.07947086,0.029901415,-0.029965885,-0.05523242,0.009467545,-0.01613832,-0.023239652,-0.016664086,0.024566475,-0.063701905,0.04330288,0.07387218,0.015452984,0.14164306,-0.006881419,0.03807457,-0.021548858,-0.050493136,-0.097226836,-0.04953491,-0.025296923,-0.033785015,0.011536151,0.029337203,-0.0047699325,0.016874498,-0.053293627,-0.028221045,-0.080070116,-0.03913875,0.10863637,-0.006035889,0.036336463,-0.0040569566,-0.023573836,-0.04745975,0.02903154,0.07877657,-2.0105904e-08,-0.042667642,-0.0149589125,0.10119689,0.023311388,-0.0713059,0.029757427,0.047686387,0.13435328,0.06750804,-0.04090924,0.054369893,0.090509884,0.079273954,-0.045401916,0.0598509,-0.008462292,0.024881097,0.050961412,-0.02980608,-0.006034429,-0.12927377,-0.019916367,-0.001720024,0.026378356,0.0073811784,-0.027404115,0.027749304,-0.02584572,0.056491535,-0.04324635,0.061011188,-0.019630827,0.065653384,-0.03452602,-0.07519493,0.012110891,0.022338266,-0.04081639,-0.022532735,-0.0067418846,-0.08323693,-0.018148853,-0.050509267,0.053853855,0.051775523,-0.062142365,-0.020077348,0.039838824,-0.03898579,0.0013157403,0.028229525,-0.053745672,-0.01296196,-0.08545532,-0.076537766,-0.019650672,-0.00053516607,0.0198671,0.042468797,-0.07790635,-0.040233165,0.040398695,0.20518337,0.044888757 +1.1.1.47,"This enzyme has similar activity with either NAD+ or NADP+. cf. EC 1.1.1.118, glucose 1-dehydrogenase (NAD+) and EC 1.1.1.119, glucose 1-dehydrogenase (NADP+).",384,1.0,-0.0751789,-0.018512119,-0.044872303,-0.028905727,0.04456595,0.076465495,-0.0578852,0.009273728,5.2371757e-05,-0.012042826,-0.012425038,-0.03867304,-0.0803396,0.034860615,-0.0069543542,-0.007067216,-0.029998578,-0.022485372,0.046954125,-0.02682665,0.018789243,-0.011105001,0.03175229,-0.00051471195,0.08362956,0.058504015,0.033237457,0.062564515,-0.017687662,-0.06707626,-0.0025834853,-0.036877956,0.021666948,-0.027011642,-0.039413903,0.077367865,-0.076447695,-0.050556634,-0.041913953,0.00444951,0.013872849,0.029864416,-0.03666637,-0.024997344,-0.030740153,-0.10176745,-0.03712348,0.06373207,0.03465609,-0.00071379513,0.009886339,-0.0026214698,0.0035281316,0.008747746,0.048296023,0.000117124255,-0.036916375,0.0006038015,-0.041398883,-0.05666941,-0.02697262,-0.07298632,0.00703984,0.020654017,0.0562475,-0.03270016,0.09101562,-0.021949446,-0.037833523,-0.03396987,-0.14647147,-0.04376792,-0.002162322,0.04567644,-0.035726696,0.036989298,-0.09007948,-0.033160616,0.07196284,-0.01004855,0.028135998,0.023437792,-0.047786113,0.048365094,0.02411283,0.006936167,0.04336289,0.0040821494,0.009719384,-0.01626169,0.024521938,-0.025112052,-0.050446797,0.043467585,-0.085512176,0.027100643,0.005870425,0.08383306,-0.0067300005,-0.10518828,0.012280571,0.108829774,-0.0341231,-0.015705125,-0.014411683,0.03746084,-0.00837094,0.10564059,-0.0318155,-0.021126715,-0.0038050343,-0.044483118,0.03471049,-0.03108015,-0.0259123,0.10874201,-0.02338938,-0.041208755,-0.058309745,-0.0112816375,0.067278035,-0.05372759,0.04964064,0.060130723,-0.01899338,0.042348716,-0.1116092,-7.959226e-34,0.08039399,-0.008189382,-0.025480568,-0.022064935,0.056964226,0.058813386,-0.10835828,0.12629107,-0.080949455,-0.03486288,-0.041922376,-0.0072327517,0.06725518,0.0035128975,-0.042076886,0.0063045025,0.0070686587,-0.078542896,0.016632704,-0.0062330817,0.026367476,0.06947325,-0.021607475,0.042813886,0.07293196,0.024322588,-0.05032096,0.07986123,-0.02049385,-0.017705474,0.055497367,-0.0940188,-0.1515002,0.023857757,0.054958,0.024867987,0.0067486106,-0.025465785,0.019805571,0.016851787,-0.060012437,0.01653547,-0.0037627944,-0.0710715,0.045981813,-0.07829884,-0.009326651,0.054811843,0.08483654,0.041166853,0.06509862,-0.022038328,0.07577405,-0.106260434,-0.053009115,0.09132501,-0.037865512,0.07949592,-0.013557984,0.09559744,-0.0027762523,0.021804143,-0.024447788,0.011862951,-0.036454465,0.0377471,-0.08735764,-0.031161882,0.038027585,0.041082174,-0.034969866,0.06916814,0.080709554,0.010426368,0.04812009,-0.000245343,-0.002137829,0.008798473,0.0124198375,0.050164152,-0.07760656,-0.04652364,-0.0058887475,-0.025634265,-0.056133263,0.0509676,0.007575576,-0.031605866,0.022267168,0.020561237,0.026171476,-0.04148398,-0.014130125,-0.03356277,0.07076619,-2.3655285e-33,0.03663951,-0.063605756,0.012978462,-0.10022648,-0.033562496,0.13343039,0.040426165,-0.15417914,-0.013475929,-0.02844913,0.08087049,0.026382528,-0.0061406177,-0.07384093,0.013411908,0.0003352229,-0.111308664,0.083814055,-0.014727308,0.028094364,-0.030921392,0.09771953,0.036193464,-0.033784654,0.06691653,-0.019581169,-0.035131793,0.05766664,0.057803147,0.0050444426,-0.014041864,0.011970688,-0.01835693,-0.012602276,-0.019206608,0.020838676,-0.053348634,-0.029839387,0.020646771,0.006373232,0.014127081,0.02573399,0.0022752194,0.034443952,0.09113167,0.035710778,-0.10247358,-0.015292799,-0.017698724,-0.088490054,0.013968089,0.08116521,-0.095928155,0.03380493,0.06827584,0.048076514,0.021321557,0.05599848,0.07973659,-0.0072892383,-0.03679375,-0.017214179,0.04961733,0.01092454,0.0436182,0.0051154266,-0.037967477,-0.036230717,0.029878495,-0.0021667578,0.059118345,0.0145987645,-0.020823952,0.017810056,0.0028531626,-0.030162219,-0.076332994,0.0059163244,-0.042117793,-0.038446005,0.05207927,0.0062750243,-0.063249454,-0.04824383,-0.027014563,0.049871616,-0.007558499,0.06287527,-0.014679417,0.05063849,-0.023744915,0.09255518,-0.074899614,-0.0028126664,0.0072678276,-3.1827735e-08,0.04602983,-0.043155577,0.033289183,-0.06754626,0.08785175,0.050282035,0.009700948,-0.026352601,0.018086053,0.0075195613,-0.012354917,0.11272729,0.008580632,0.008852471,0.038448513,-0.06282045,-0.028920194,0.003919771,-0.013773727,0.040232226,-0.06870499,0.0076751797,-0.11443904,0.05575686,0.011167965,-0.068111636,-0.004921925,-0.048071694,0.084126055,-0.031159487,-0.0043607904,0.014810453,0.063545726,-0.06672761,-0.024553502,0.043416943,-0.023650445,0.0020692896,-0.08380127,0.07430255,0.028649496,-0.15167849,-0.026885435,-0.008085039,0.040851504,0.030276086,0.09310043,-0.10396407,-0.058461625,-0.017818084,0.040177524,-0.07484377,0.033963434,-0.07337073,-0.072227195,0.022077082,-0.057755735,-0.07667928,0.036966864,-0.022704696,0.019194875,-0.005412335,0.10765774,-0.0023611116 +1.1.1.48,"This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.",384,1.0,-0.014937492,-0.102626316,-0.07629312,-0.037838396,0.110684335,-0.0076883556,-0.038464215,0.04504776,0.029538084,0.04033641,0.027171496,0.027389254,-0.06145389,0.07644521,-0.058541577,0.047360737,-0.058913708,-3.0370342e-05,0.04271715,0.032319847,0.15088381,0.06208572,0.020775242,-0.025338534,0.052481107,-0.059116445,0.04461852,0.00038707157,-0.043235376,-0.05576541,0.040494997,-0.010725463,0.06932284,-0.04968813,-0.026864933,0.06748136,0.013721532,-0.038866103,0.070523195,-0.012771576,0.006941528,0.008826235,-0.014170963,-0.009494718,-0.017331606,0.010082554,-0.030532926,0.05310525,0.026763957,-0.0076836646,-0.03255116,-0.038880624,-0.03203692,0.018385496,0.07858547,0.0696423,0.02921487,-0.045003064,-0.011902058,-0.015830541,0.07231667,0.071458414,-0.000630699,0.008392031,-0.01627717,-0.075255744,0.0055932635,-0.028580856,0.027237793,-0.097711235,-0.05304747,-0.05562157,0.0028195006,0.0027600464,-0.02116823,0.045891922,-0.017472457,0.0023670027,0.079226255,-0.053251516,0.060592413,0.03521385,0.020548185,0.07431054,-0.002155782,0.0049945163,0.096907936,-0.010505303,0.06688661,-0.02666477,-0.0027913237,-0.03920248,-0.102293566,-0.02995598,-0.04707313,-0.028458558,0.023210334,-0.017304173,0.035867337,-0.040167484,-0.03617681,-0.02182654,0.040162712,-0.05654468,-0.119948946,0.0047308463,-0.021922776,0.08261295,0.06318302,-0.015097857,0.039849,-0.0018541485,0.0411333,0.07256111,-0.023380874,0.03996201,0.046821672,-0.062638715,-0.10878668,0.02590743,0.029726245,-0.04061263,0.055898767,0.03854177,-0.04000285,0.029006142,-0.066300064,-2.5029309e-33,0.08657612,-0.013610118,-0.012242322,-0.03189677,0.035980336,-0.0028566767,-0.10515595,-0.026181228,-0.04258502,-0.03086091,-0.050994176,-0.082164764,0.011913151,0.051279094,-0.06387209,0.00020720909,0.049431793,-0.026716258,0.03304549,-0.0037754024,0.0013295924,0.07265614,-0.048936877,-0.026612274,0.06805801,0.029555349,0.023343993,0.040763263,0.07619073,0.0025230977,0.024506304,-0.14672814,-0.071563646,0.04423252,0.069345124,0.053482503,-0.054406922,-0.03807049,-0.036586184,-0.018557433,0.053626884,-0.016828287,0.009838333,-0.030463003,-0.020012887,-0.027266756,-0.04184545,0.029391376,0.040535454,0.09420519,0.051759943,-0.044714507,0.05634261,-0.06667015,-0.061007887,0.023587197,-0.091337495,-0.030672902,0.059685584,0.0034077691,-0.03358057,-0.019463407,-0.06817107,0.076474294,0.05358086,-0.01671044,-0.026886461,-0.039263226,0.021352965,0.04427442,-0.1318791,-0.026774274,0.0257885,-0.03249605,-0.019301487,-0.046294592,-0.038224246,0.06668948,0.0234837,-0.04155627,-0.03470415,-0.031106416,-0.012924303,-0.018297315,0.009568095,0.070401214,-0.07695358,-0.0187944,-0.043297376,0.018111642,0.033537395,-0.06567163,-0.06201033,0.049708344,0.052680142,-4.5793513e-34,0.045430455,-0.10545746,0.085429505,-0.040175185,-0.04165219,0.14313355,0.012870114,0.008471736,0.06292809,-0.042767916,-0.0029573564,0.026856175,-0.016151154,-0.08232468,0.023812152,0.022108996,0.024018265,0.026312847,-0.067838356,0.009204973,-0.0047536725,0.100773886,-0.008103055,-0.05706956,0.023530511,0.0009022911,0.011847449,0.058954626,-0.031044548,0.020589009,0.028544035,0.01589346,-0.01908262,-0.09794397,-0.03255539,-0.009716593,-0.056585107,0.016027803,-0.01359174,0.0043241894,-0.04259515,0.012942878,0.022258094,0.025620146,-0.0120168235,0.06508286,-0.0650808,0.025686456,0.08293586,0.030044908,0.028977565,-0.055667292,-0.0138698565,0.01071955,-0.014241864,0.048162278,0.042621955,0.052856795,-0.058255207,-0.006422288,-0.052703936,-0.048182756,0.042291436,-0.013841635,0.034878127,0.008608812,-0.03259285,0.05387152,0.022132054,-0.0580071,0.074957535,0.045008626,-0.010443527,0.079897076,-0.05931394,-0.052054193,-0.11956004,-0.055610728,0.022039931,0.080642626,0.047251996,0.035079174,-0.0018290782,-0.020843497,-0.014173215,-0.08504399,0.030962827,0.11549353,0.0077379453,-0.0046872175,-0.07142689,0.016685378,-0.0571539,-0.0098725045,0.091970906,-2.5995309e-08,0.010701789,-0.021545114,0.0027008487,-0.046300195,-0.016056389,-0.018065868,0.029880725,0.10744822,0.034084603,-0.038144153,0.007685004,0.15581803,-0.035688203,-0.011511789,0.0001927979,0.005756543,-0.0039768945,-0.000216387,-0.052247338,-0.0037716024,-0.014759786,-0.06496587,-0.071429916,0.052284256,0.039169174,-0.0853679,0.035491675,0.074921675,-0.047814,-0.08980858,0.05142095,0.03685153,-0.01964749,0.009007755,-0.13759528,0.023542257,-0.036270276,-0.033953037,0.031899005,0.06697088,0.0935705,-0.03644213,0.047461856,-0.017135398,-0.08848878,0.024207111,-0.06010544,0.052810624,-0.034439888,0.07867908,-0.0166348,0.020686997,-0.061003,-0.039109685,-0.083283566,-0.042132955,0.034532893,-0.06328358,-0.01695009,-0.045321003,0.0171564,-0.0024326802,0.18841957,-0.02507796 +1.1.1.49,"The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).",384,1.0,-0.064354606,-0.0071255583,-0.014113975,-0.04862785,0.046159223,0.052982632,-0.065388285,-0.0146482615,0.032966007,0.036755268,0.005356235,0.033667482,-0.124967955,0.021261754,-0.019479567,-0.0016906696,-0.09469447,-0.007895728,0.06160859,-0.022168985,0.0878541,-0.019127123,0.032114565,-0.078378804,0.10144144,0.05501925,0.09142585,0.026771348,-0.0048717433,-0.065302126,-0.056757227,-0.023009947,-0.008390961,-0.10138081,0.058167163,0.082094535,-0.04840232,-0.017774817,-0.020475505,0.025424408,0.046639863,0.0026531026,-0.00748051,-0.037538726,-0.03383703,-0.075913645,-0.02067906,0.12267598,-0.017906507,-0.01358446,-0.041804794,-0.03243889,0.009444893,-0.019192478,0.05945396,-0.0323123,0.039394416,-0.000934017,-0.015682092,-0.09255174,0.0018678166,-0.067143604,-0.04311867,0.028214423,0.07712465,-0.06035759,0.0808721,-0.029536901,-0.037311632,-0.020634195,-0.13606995,-0.0057983263,0.007020631,0.0018417336,-0.00757527,0.05972095,-0.103232995,-0.0204193,0.04805879,0.01804497,0.06121319,0.045439623,-0.023302916,0.08603739,0.08217303,-0.010138589,0.017012086,0.028669875,0.014894978,0.023609627,-0.0329663,-0.06535426,-0.038032867,0.039254252,-0.12437117,0.03622647,0.008925962,0.009560561,0.018636042,-0.07677737,0.027630264,0.103204764,-0.023530308,-0.03671996,0.010879242,0.05139176,-0.07128838,0.13990484,-0.013502541,0.0051929015,-0.021589965,-0.012520202,0.062964566,-0.0121445535,0.003139569,0.09345187,-0.062388334,-0.0439697,-0.022047633,0.014742655,0.001899364,0.014907651,0.005963503,0.088944085,-0.04658746,0.053636424,-0.12647507,-1.1006317e-33,0.08858,0.03916909,0.0108939875,-0.049262438,0.040139,0.048604418,-0.062854744,0.059566192,-0.09524407,-0.019060705,-0.028242668,-0.07534088,0.07987875,-0.021932987,-0.036588307,0.00039196303,-0.024618946,0.0014645297,0.02590561,0.04365162,0.044599403,0.06279693,-0.050127782,0.023278775,0.041886125,0.059278447,-0.07441847,0.06794413,-0.03900288,-0.011378694,0.071716145,-0.07502433,-0.10564532,-0.018094596,0.06512191,-0.05259948,-0.0021080931,-0.0727308,-0.009788068,0.0542296,-0.062219407,0.014642057,0.0056773727,-0.012032022,0.011497452,-0.06324715,-0.020672113,0.02582268,0.073285274,0.062416006,0.021835124,-0.017530492,0.106360495,-0.051107254,-0.049542256,0.015300744,-0.07524715,0.0060846354,-0.013212503,0.07293926,0.057304535,0.023174413,-0.052651305,0.031574868,-0.044888124,0.0008679706,-0.052655157,-0.04875693,0.036968134,0.100440465,-0.06390146,0.032839455,0.069936186,0.0070260796,0.043089084,-0.030843597,0.020218296,0.013731161,-0.0042586406,0.024903752,-0.037370194,-0.04560696,-0.030569417,-0.07737843,-0.044510733,0.010783189,-0.02822191,-0.0606794,-0.0014970842,0.02167935,0.029859474,-0.033898294,-0.073652476,0.024134658,0.03819325,-7.7802895e-34,0.109875046,-0.033784766,0.062445924,-0.13247654,-0.06953631,0.061115827,0.069517106,-0.14005402,0.029976595,-0.037096094,0.016124265,0.030825648,0.055947024,-0.022916878,0.014098263,-0.028251233,-0.05673031,0.06001276,0.04237662,0.007192856,-0.02504107,0.097727686,-0.016579466,0.0046010325,0.060518943,-0.03314928,0.009889855,0.031438,0.016928516,0.046048988,0.0015964886,0.02163033,-0.06961219,0.023029448,-0.070843376,0.014526141,-0.08563799,-0.023139047,0.05167777,0.07423028,0.03410457,0.01611919,-0.038342193,-0.0060112798,0.035639606,0.016846888,-0.070894495,0.049872607,0.0051980847,-0.09071191,0.033090338,0.07059104,-0.026308862,0.055914797,0.059008777,0.050383594,-0.013962877,-0.018737199,0.05125195,0.003990558,-0.030495035,0.00024917693,0.07221366,0.011237739,0.057875555,0.027779836,-0.002675533,0.03205821,0.0042114793,-0.020176176,-0.0037983062,0.047514264,0.015548805,0.04861315,0.017682578,-0.039184045,-0.10767557,0.015320362,-0.010432521,-0.054746035,0.024683874,0.012642005,-0.039626505,-0.050780218,-0.015619063,0.028752137,-0.0022477286,0.07231729,-0.0074417247,0.050078314,-0.032999188,0.026213743,-0.021381684,0.032431386,0.018160665,-3.2411346e-08,0.01850148,-0.014835432,0.021846624,-0.04452193,0.04882251,0.04959347,0.05339912,-0.029544225,0.05287338,0.045546338,0.0050992207,0.10789541,0.065655924,-0.0031555959,0.028955517,-0.018764213,-0.019177608,-0.025715157,-0.03126141,-0.015762592,-0.058329087,-0.007055999,-0.12504692,0.07637004,0.054797757,-0.052188214,0.033911992,-0.010772852,0.056369804,-0.030548962,-0.015698139,-0.011494993,0.03929981,-0.052486654,-0.023706056,0.08786312,-0.031392638,-0.020276029,-0.03266565,0.04644345,0.010965132,-0.13346241,-0.04323922,-0.042252142,-0.010432455,0.0845535,0.032136224,-0.023006562,-0.118624516,0.042915396,0.007987152,-0.03456079,-0.015170392,-0.030948725,-0.047154088,0.006625188,-0.02264325,-0.06655929,0.004901631,-0.017574998,0.03129947,0.03039432,0.17148732,-0.054349463 +1.1.1.50,"The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).",384,0.99999994,-0.06865407,-0.03168317,-0.056014005,-0.11343485,0.04855027,0.057749256,-0.07270668,0.0068654553,0.011674458,-0.022817986,-0.005664217,-0.015448693,-0.1143321,0.01709473,-0.020951945,0.025400506,-0.028248182,0.020780817,0.02428334,-0.082043745,0.08512586,-0.029292382,0.040834427,-0.028263127,0.052379213,0.020736352,0.042299777,0.052742105,-0.04861209,-0.037206117,-0.01806801,-0.0006904477,0.0049238284,-0.00828489,0.013041886,0.09689062,-0.1178041,-0.066599734,0.0042604404,0.09708919,0.061801996,-0.060883045,-0.051865585,0.002980587,-0.04260598,-0.08205288,-0.0610417,0.088924445,0.011294246,0.07500662,0.00725449,-0.041350853,0.03107455,0.050472524,0.023714472,-0.043614686,0.036690377,0.045128413,-0.040830035,0.048786137,0.0001195059,-0.06456959,0.0024521449,0.03783354,0.07411344,-0.0063313623,0.036119234,-0.07599576,-0.064618245,-0.037708346,-0.058077477,-0.020557646,0.01854441,0.011814928,-0.04508892,-0.0027564294,-0.049986247,-0.014107632,0.059711378,-0.043167546,0.024437178,0.036888763,0.0014719365,0.07611764,0.067629665,-0.012714842,-0.060210835,0.051305126,-0.0013861868,0.040653203,-0.03531846,-0.042127363,-0.038672425,0.048339378,-0.020296782,0.050131354,0.010054122,-0.0289414,-0.012999826,-0.0497403,-0.002862147,0.09315067,-0.035604283,-0.017690636,-0.05174361,0.06579051,-0.060260817,0.08876892,-0.052132297,0.018002354,-0.023017565,-0.042547144,0.07722497,-0.0028616858,-0.015765848,0.1085785,0.04113585,-0.039940972,-0.04495887,-0.08239144,-0.001465853,-0.03960525,0.0030863422,0.013695838,-0.022499774,0.07570243,-0.09225982,1.442382e-35,0.12697749,0.017794594,-0.06202267,0.0060632476,-0.022926329,0.067838706,-0.053837437,0.058660883,-0.09259464,-0.0010631401,-0.019130696,-0.054604355,0.062125046,0.026604008,0.00025755606,0.0047405893,0.061727718,-0.025525877,-0.0081177205,-0.035223406,0.003101718,0.079258196,-0.10154808,-0.022871207,0.0054604216,0.09115974,-0.04310385,0.07533238,0.011125788,-0.025464037,0.032784745,-0.12544775,-0.08690266,0.01985565,0.0490603,-0.009824404,-0.03885087,-0.05192072,0.0032013152,0.046850942,-0.029146077,0.027579762,0.037777346,-0.08071877,0.04600949,-0.029543506,0.00031674714,0.041812833,0.088491,0.031062787,0.08103839,0.015161276,0.08500797,-0.085607715,-0.054056298,0.06713438,-0.053648267,0.028931668,-0.0029682699,0.061948612,0.0028475039,-0.01897191,0.026294056,0.07691811,-0.037113838,0.022821592,-0.079503,-0.054467503,0.010172992,0.09080816,-0.034512047,0.037640315,0.092825785,-0.0020974441,0.024211235,0.015135932,0.006636164,0.014147677,0.02667303,-0.008857576,-0.017815743,0.01454645,0.002870565,0.00091727707,-0.109121695,0.046145186,0.014381791,-0.046587747,0.012877592,0.02088279,0.06375302,-0.07197199,-0.047844276,-0.027192371,0.044468164,-2.4931978e-33,0.06463468,-0.032926995,0.028414669,-0.18535167,-0.037169512,0.12994128,0.041013177,-0.057803128,-0.03966317,0.0070884996,0.058768116,0.015504056,-0.04334311,-0.12625438,0.049257692,0.006961853,-0.06635602,0.04044949,-0.047347996,0.005494043,0.10438235,0.10282973,0.006013468,0.0539636,-0.015216675,-0.052553248,0.014120586,0.050431944,0.004617431,0.057242136,-0.027411945,-0.058449853,-0.055143904,0.007550778,0.072278075,0.0375507,-0.056920018,-0.0069779856,-0.021849846,0.006483302,-0.009180212,-0.0061794277,-0.04533012,0.077187225,0.04356406,0.096869305,-0.084683575,-0.01865868,0.0024695466,-0.051130008,-0.033720694,-0.012556893,0.009577266,0.011225976,0.036773846,0.032261115,-0.024681484,-0.05381928,-0.019701317,-0.00753536,0.027192425,-0.022367734,0.021261182,0.014642682,-0.023032637,0.037815943,-0.023101913,-0.04894662,0.06600996,0.031410053,0.049524285,-0.016552996,-0.0027429347,0.062921576,-0.049214754,-0.12482427,-0.057181492,-0.0011011272,-0.03083547,0.041019175,0.04263036,0.040532503,-0.024454335,-0.015377848,0.0022131067,-0.011515201,0.031326316,0.09795468,-0.0006056192,0.020279665,-0.009953622,0.06423706,-0.12729213,0.015121952,-0.022302201,-3.9669413e-08,0.050204493,-0.020633018,0.07745794,-0.071924366,-0.01135687,0.0068729436,0.045698717,-0.02243257,0.056969922,0.019745369,0.013112203,0.102172144,0.035816185,-0.005467823,0.084650114,-0.08655845,0.014850936,-0.010709113,-0.027071677,0.003376438,-0.05638735,0.022912156,-0.0696769,0.027209928,0.0333208,-0.013775765,-0.024527878,0.02483466,0.06158376,0.06714005,0.02012994,-0.001558781,0.037223537,-0.054988675,-0.059533082,0.05676857,-0.014170863,0.0137970885,-0.011713185,0.00019654908,0.0045056804,-0.11431172,-0.016113672,0.05321598,0.0025867245,-0.0057010725,-0.026186828,-0.060016852,0.00523099,0.035654612,-0.0077727186,-0.044445727,-0.019218707,-0.014599725,-0.0871394,-0.012369183,-0.06980706,-0.08517248,-0.022345116,-0.07727787,0.06476388,-0.0050973813,0.15948968,-0.026062507 +1.1.1.51,Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.,384,1.0,-0.04158419,-0.04291192,-0.08254821,-0.10981603,0.042697188,-0.0044767032,-0.007814623,-0.032616135,0.00016862647,-0.0024466987,0.02325444,-0.0059654354,-0.109848864,-0.004007288,0.007049036,0.02959905,-0.015775712,0.0338654,0.032390345,-0.049827356,0.034459226,0.031487044,0.016145077,-0.0066265627,0.029963741,0.015757162,0.03659679,0.04849926,-0.042347807,-0.046685204,0.03693949,0.04347266,0.058509644,0.032425404,-0.04629199,0.06334555,-0.11045146,-0.089807704,0.020175286,0.10882935,0.088875115,-0.018412875,0.010517088,-0.0131041575,-0.06085496,-0.066561155,-0.123707965,0.07763339,0.056166377,0.051041927,0.011886002,-0.060342498,0.0479886,0.07847679,0.010441445,-0.010025083,-0.10488951,0.01112198,-0.06217528,0.03663023,-0.050017048,-0.0020771946,0.011240566,0.028459078,0.0595403,-0.020177774,0.02612275,-0.071247265,-0.050257027,-0.038536508,-0.020849185,-0.06308668,0.017931113,0.016113613,-0.090024784,0.046807867,-0.03173217,-0.029420076,0.026924498,-0.08354909,-0.018616887,0.004820661,0.06909784,0.1065399,0.0046227006,-0.04136161,0.024392486,-0.03143774,-0.03116292,0.14402446,-0.0012120631,-0.030066412,-0.00723015,0.074759685,0.009102308,0.06125042,0.031912602,-0.03868395,0.007540275,-0.022843521,-0.06411731,0.08220627,-0.0267521,-0.011287933,-0.06578516,0.034278266,-0.0037810972,0.006926783,-0.025773933,0.0019069406,-7.452835e-05,-0.052726794,0.0627362,-0.0118057,-0.049444716,0.07652655,0.025520526,-0.062893026,0.011465132,-0.06644795,0.0067047793,-0.053256832,0.03349412,0.009739308,-0.046364866,0.08208109,-0.04613689,-3.304019e-34,0.09346462,-0.04056119,-0.033486813,0.007865931,-0.01295748,0.0812801,-0.072157644,0.061054226,-0.043057147,-0.03186489,-0.07301992,-0.0029836805,0.12540084,-0.02203873,0.0007907181,-0.06928161,0.0363124,0.024557719,0.05518139,0.019617654,0.03729282,0.059480816,-0.070916705,-0.0762985,-0.083277255,0.056940768,-0.048715074,0.061757464,0.07755575,-0.0099185575,-0.002188589,-0.032931015,-0.05473807,0.06270723,-0.011527575,0.022838924,-0.05880804,-0.06650661,-0.00779951,0.06647278,0.03965902,0.005166994,0.030929208,-0.093866445,0.07217548,-0.0003244591,-0.030992242,0.03296223,0.10033002,0.06246649,0.050821725,0.03618695,0.07863182,-0.07607652,-0.0065239905,0.025237538,-0.075106405,0.014488511,0.010975348,0.041138303,-0.05498204,0.048574593,0.0019832784,0.0063196793,-0.027380046,0.039629877,-0.04659971,-0.07805508,-0.066216886,-0.010535957,-0.055512924,-0.0057572955,0.107096374,-0.027635152,0.03917982,0.06500597,0.008867136,-0.007739598,-0.001979193,-0.023996139,-0.05303307,0.00780186,0.031357955,-0.002195354,-0.019276887,0.073577605,-0.055208176,-0.05284808,0.028954253,0.016296543,0.04569598,-0.07008846,-0.10887234,0.014563487,0.0348622,-2.6293379e-33,0.025819017,-0.06590535,-0.03903131,-0.10894888,-0.01981369,0.082955204,0.052672338,-0.031472605,0.02948312,-0.0027837048,0.058233622,-0.011552405,-0.06518149,-0.13656195,0.07461302,-0.0021291121,-0.04588365,0.04958354,-0.13567612,-0.023598846,0.05675536,0.07055464,0.012716283,0.14072572,-0.0013588637,-0.0053731734,0.059309453,0.0043716817,0.031928968,0.048953313,-0.01675306,-0.0051508825,-0.031573683,0.0401175,0.04516487,0.04575025,-0.06621149,0.013803078,0.01658624,-0.06394259,-0.038628407,0.011834218,0.04832311,0.09212353,0.08998901,0.07715305,-0.034272134,0.037437584,-0.037602346,0.02272302,-0.083552726,-0.03163505,-0.0017953875,0.01754138,0.0051741595,0.015683645,0.002505775,-0.02564356,0.043916695,-0.020340001,0.061976906,-0.022844037,0.010487588,0.008924496,-0.04929543,-0.011764528,-0.03274348,0.002572084,0.058825728,0.10031519,0.055954404,-0.03194654,-0.044161156,0.03216027,-0.002646563,-0.06597497,0.008732819,-0.036587127,-0.043997046,-0.022430666,0.032581706,0.08236152,-0.02110344,-0.022800786,0.0100242095,-0.07187824,0.03017424,0.042520504,-0.004421972,0.056410078,-0.026226657,0.014022282,-0.12782884,-0.0213959,0.006489708,-2.8211364e-08,0.085260436,-0.023127552,0.06520523,0.008503703,0.005068849,0.008402894,0.0040331054,0.062468033,0.112183616,-0.055759866,0.013888888,0.073578864,0.03889681,-0.01786775,0.107268326,-0.07477711,-0.0037384853,0.016067985,-0.0407554,-0.015193506,-0.10101777,-0.04757168,-0.045650452,0.03211856,-0.037715092,-0.06904836,-0.016834239,0.0076496718,0.022705322,-0.02148968,0.037151642,0.034841105,0.06653159,-0.02917291,-0.021998888,0.07644891,0.0042512077,-0.013993992,0.030290758,0.00033780513,-0.03399825,-0.078504056,0.0043358835,0.016945949,0.014468914,-0.004708847,-0.01897701,-0.011716815,0.015515547,-0.020656016,0.0054236935,-0.027354868,0.013183368,-0.021410335,-0.05388172,-0.058398172,-0.10917344,-0.10443638,0.0453319,-0.04864757,0.003918108,-0.018680686,0.13649127,-0.0008620849 +1.1.1.52,"Also acts on other 3alpha-hydroxysteroids with an acidic side-chain. cf. EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+).",384,1.0000001,-0.08802378,-0.05264867,-0.054803677,-0.07862055,0.0021557342,0.054557927,-0.08271356,-0.008664015,0.03281868,-0.019809997,0.042122953,0.013424809,-0.054113522,-0.0041257557,0.007840785,0.07052597,-0.022076,0.025586538,0.06927876,-0.03726977,0.02630986,0.03111417,0.013966947,-0.024439806,0.023193527,0.058829,0.058078926,0.03850307,-0.05676205,-0.08714954,0.024819251,0.023385786,-0.055774678,-0.022185171,-0.021342209,0.101797,-0.10530193,-0.034343425,0.05535175,0.08207427,0.06807365,-0.030276123,-0.018746616,-0.012469997,-0.08198278,-0.06835059,-0.064214244,0.08821187,-0.013227789,0.013582895,0.012241965,-0.02458548,0.01954556,0.056993857,0.03376473,-0.015541805,-0.035570942,0.06600308,-0.031834837,0.006313811,-0.007328947,-0.053500522,0.035798747,0.02091383,0.05054535,-0.047723178,0.043189075,-0.059515037,-0.059364922,-0.053426065,-0.111178555,-0.044261087,0.06718452,-0.0051821806,-0.077623315,0.041681964,-0.038719382,-0.0321075,0.078368425,-0.055165596,-0.01878516,0.007740328,-0.018026188,0.09179828,0.05222069,-0.01959337,-0.026711227,-0.0011698343,-0.050208364,0.046832785,0.0054661655,-0.046832755,-0.0022863152,0.06883073,-0.060834616,0.060747176,0.008758983,0.0035907882,-0.04883733,-0.057201356,-0.0048365807,0.074415736,-0.0052448125,-0.039308075,-0.050854698,0.035507355,-0.044373427,0.029377466,-0.050894488,-0.012101103,-0.03214482,-0.062572934,0.02437129,-0.031843696,-0.025119647,0.095209,0.040806558,-0.058351304,-0.06002557,-0.14059435,0.00150744,-0.06093244,0.026908632,0.0053508217,-0.016313536,0.022814626,-0.06974809,4.164088e-34,0.1001104,-0.007349202,-0.032692723,-0.030198263,0.0009057292,0.031896267,-0.08797061,0.044775702,-0.07181936,-0.009599364,-0.028473787,-0.009562089,0.09442973,-0.008020885,-0.05393478,-0.011914341,-0.015517052,0.010567261,-0.0009836568,-0.019404601,-0.04074586,0.05862255,-0.03948365,-0.040909123,-0.056353513,0.053184293,-0.020360945,-0.0011842188,0.023657713,-0.02129915,0.064714946,-0.07213683,-0.10269567,0.077026665,0.008608944,0.07298914,-0.048554234,-0.07929736,-0.0286595,0.074004926,-0.028433187,0.025555527,0.018788058,-0.07739127,0.03580111,-0.035090316,-0.027448058,0.045398228,0.10636657,0.05176614,0.07174363,-0.009659299,0.10601526,-0.07109046,-0.03095023,0.052718002,-0.05865371,0.029163308,-0.005666181,0.075342774,-0.020394085,-0.019500162,-0.041454587,0.010109448,-0.050273594,0.031888925,-0.08611828,-0.069857486,0.037899986,0.013240364,0.011334859,0.01999193,0.13804379,0.021355627,0.015617254,0.03374134,-0.021735577,0.023757303,0.039353304,0.034001958,-0.017347066,-0.03600163,0.024864454,-0.022852348,-0.023800246,0.070730135,-0.009365385,-0.05635457,0.034873758,0.070161924,0.046729185,-0.040993277,-0.021547101,-0.0011888645,0.06714114,-2.478018e-33,0.06341158,-0.052707247,-0.041992273,-0.15181631,0.00012265338,0.10206675,0.05009831,-0.051273335,-0.048535038,-0.016627723,0.07341459,0.038550973,-0.040229753,-0.06586661,0.08540286,-0.035831675,-0.003380413,0.046484847,-0.05051099,-0.027892748,0.069996454,0.09053155,0.0009085139,0.11490595,-0.0028011038,0.0067552594,0.016044343,-0.00626308,0.07270214,0.06526165,-0.030894203,0.009816892,-0.06921095,0.029877247,0.07904086,0.051279854,-0.09058587,0.0274597,-0.019866642,0.0022521028,-0.011679005,0.0051841377,-0.034792498,0.06504377,0.09005228,0.06494814,-0.06601587,0.023725541,-0.03547785,-0.05061796,-0.048899412,0.041723788,-0.031090146,0.027308155,0.064454295,0.034091193,-0.012720373,-0.024230404,0.10218067,-0.04938932,-0.043554045,-0.0039516627,0.012014835,-0.0188117,-0.0018570081,0.030218003,-0.0090969205,-0.039210536,0.047672573,0.023500009,0.06899916,0.0067316005,-0.00020735785,0.008255583,-0.0011029489,-0.09904453,-0.04788426,-0.043791343,-0.02863362,-0.010733581,0.0556082,0.029856293,0.013785161,-0.027862191,0.009425118,-0.060211055,0.0006582695,0.066001505,-0.017246798,0.011092594,0.0067667845,0.041098125,-0.11235392,0.06356481,0.023848938,-3.2336533e-08,0.0318622,-0.025731439,0.0638981,-0.055414632,0.009787115,0.01050827,0.044375524,0.04036147,0.06859759,-0.018147256,0.0035217516,0.12456477,0.07978394,0.032002676,0.07347233,-0.035963457,0.009341405,0.000804297,-0.02196259,-0.026365085,-0.13082615,-0.025165785,-0.06666791,0.04375224,-0.019317634,-0.017252162,-0.015558363,-0.013352697,0.08831725,0.006498849,0.04195276,0.0484501,0.068955615,-0.062348768,0.011632056,0.067001,-0.017215624,0.023945576,0.0019432341,0.048948586,-0.04666737,-0.097793356,0.016047943,0.034396388,0.04668464,0.021950178,-0.027207537,-0.028544812,-0.06331962,0.014105736,-0.008503977,-0.05032984,0.029691951,-0.047073916,-0.11507241,-0.030618012,-0.046808627,-0.10579159,0.005479961,-0.062597334,0.028228974,0.035885055,0.17489035,0.0026628335 +1.1.1.53,The 3alpha-hydroxy group or 20beta-hydroxy group of pregnane and androstane steroids can act as donor.,384,1.0,-0.059169553,-0.027937442,-0.08469264,-0.045107238,0.014851814,0.036965996,-0.008453495,0.047576405,0.028095627,0.03196412,0.010971581,0.011433717,-0.10443494,-0.018276952,0.050281443,0.03833796,0.0037727254,0.041678436,-0.0023092157,-0.011029114,0.027506458,-0.08661753,0.033597622,-0.0061458205,0.049227353,-0.01404053,0.012967962,0.081783816,0.00018194715,0.023993898,-0.0734221,0.0018726232,-0.032807317,0.00017522753,-0.15240695,0.10840728,-0.08397592,-0.020984912,-0.0023948785,0.1245222,0.05848968,-0.059342388,-0.03489583,0.05968542,-0.02245855,-0.07860384,-0.059312914,0.043781348,0.048392296,0.014235262,0.055299494,-0.08247199,-0.006313743,0.095526434,0.009337344,0.015242956,-0.036005896,-0.010769676,-0.0472829,-0.008799314,0.015005918,0.005072803,-0.010279386,0.02046727,0.010816191,0.07525766,0.015998922,-0.0063039274,-0.021032955,-0.038478177,0.07594823,0.027931055,0.05130766,0.10414668,-0.038078155,0.07083358,0.00024208619,0.09042795,-0.031708084,-0.016565105,0.015848344,-0.011643399,0.022008171,0.072889194,0.009064505,0.023383543,-0.06674731,0.017857429,-0.045863356,0.062457044,-0.08816396,0.053820677,0.028051123,0.02441032,-0.08959008,0.02708823,-0.042640753,-0.0797622,0.020396404,0.0064478978,0.023353718,0.07494502,-0.0074715842,0.028006572,-0.06886016,0.010107992,-0.056288164,-0.032211106,-0.02676109,0.059552785,-0.010829863,-0.009375347,0.08495225,0.028214362,-0.0802551,0.091257185,-0.045068905,-0.04458155,-0.03378611,-0.09119694,-0.009418181,0.032024916,0.05178585,-0.023214363,-0.010870822,0.024782956,-0.03676669,2.2295581e-33,0.03887817,0.01732476,0.04459298,0.053488344,-0.0839455,0.089228116,0.032702122,-0.033391207,-0.061347596,-0.09186694,-0.075425684,-0.055566676,0.04573293,0.009576657,-0.075260036,-0.022782588,0.022901893,-0.016428057,0.080899924,0.011648404,-0.041813046,0.099081874,-0.045641515,-0.022988016,0.0009965895,0.037055112,0.013975243,0.0026091763,0.013881796,-0.0019011479,-0.028848723,-0.030821096,0.01621365,-0.047931064,-0.052646652,0.00072140445,0.03134345,-0.056927804,0.0037190316,0.058750626,0.046956915,-0.054141965,0.068233505,-0.031634014,0.023043584,-0.03902555,-0.072911985,-0.077282965,0.011593955,0.04674528,-0.015456864,-0.060758296,-0.03409254,0.035713773,-0.070660174,-0.002485512,-0.07801332,0.060241155,-0.014718049,0.050643988,-0.009034081,0.039095175,0.03438126,0.02092765,-0.14480971,-0.005767342,-0.037183948,-0.08309775,-0.099862024,0.03200471,-0.0145134935,-0.02777138,0.024003226,0.055307537,0.026029723,0.07363952,0.053882536,0.072521284,0.0616662,-0.036713954,-0.020275597,-0.029146755,0.039083008,0.014612785,-0.027030401,0.0003323966,-0.0028416908,-0.067253254,0.023455735,-0.043720882,0.0020586713,-0.00072442304,-0.030769994,-0.07097859,0.0441101,-3.9158692e-33,0.06978515,-0.10138987,0.046382923,-0.117775455,0.06783228,0.07497684,0.08406102,-0.0982389,0.026668396,0.07252571,0.048799824,-0.029579263,0.026404109,-0.15343645,0.0067925695,-0.06394148,-0.035350304,-0.01047155,-0.030070588,-0.048109077,0.024429362,0.10230909,0.022748033,0.07439311,-0.037683878,0.00061545207,0.016814824,-0.013756241,0.039624434,0.077344686,0.01845979,-0.02191165,-0.03454523,0.06602999,0.04913372,0.04946347,0.005084918,0.03201142,-0.027537651,-0.051544733,-0.08406181,-0.058888648,0.034118824,0.043776225,-0.018312568,0.069849536,0.029276341,0.024825053,0.08041359,0.03726257,-0.032770228,-0.05770589,-0.014938692,0.044730388,0.034385487,-0.035958435,0.04032326,-0.12982398,0.049230717,-0.09729106,0.020980276,-0.020670615,0.02290735,-0.061043758,-0.01240544,-0.011622031,0.023307212,-0.01979898,-0.023358416,0.07296229,0.02777736,-0.050192337,-0.036270052,0.02433047,0.0012680067,-0.06230475,-0.070294514,0.0014588833,-0.009648969,-0.028036997,-0.021331651,-0.023388337,0.03238587,0.030478379,0.025516132,-0.031831883,0.048092466,0.035281334,-0.022629816,0.0038915898,-0.022312308,0.08746033,-0.066805705,-0.0032780862,0.041732803,-3.2808913e-08,0.05453494,-0.0009257186,-0.008428252,-0.024671772,-0.053267498,-0.105357066,-0.036692146,0.04635922,0.096377,0.013973098,-0.09803285,0.097540535,0.053208873,-0.01909234,-0.014279661,-0.044499084,0.022784932,0.07075582,-0.01998711,-0.07354149,-0.061693393,-0.021058869,-0.039922923,-0.045575563,0.012518295,0.01992079,-0.0064397706,-0.0013134185,0.04905385,-0.0095733525,0.079392895,-0.057250742,-0.025380598,0.07899377,0.041827064,0.08450759,0.008250341,0.03972315,0.0019969037,0.021236742,-0.05127155,-0.07351906,-0.007251467,0.078902975,-0.0513243,-0.032312635,-0.01610215,0.020501895,0.010233543,-0.0064315433,-0.010442845,-0.056019776,-0.019818613,-0.058556188,-0.087135695,0.039694972,-0.048447084,-0.0022826763,0.08280214,-0.0029705213,-0.010088979,-0.047063336,0.18459177,0.034141093 +1.1.1.54,Also acts on saturated primary alcohols.,384,0.99999994,0.027792266,-0.0796103,-0.0076559423,0.06613285,0.014927688,0.011274256,-0.029676316,0.013041098,-0.008217797,-0.05885984,0.018839797,0.056632362,-0.10926507,0.08715959,0.008884136,0.04187132,0.05218434,0.017111072,0.017731681,0.0053617214,0.054230183,-0.02965565,0.035441406,-0.023466507,-0.014867742,0.04572034,0.0017824186,-0.0045511,0.06838561,-0.034591336,0.0003691126,0.07604352,0.023971478,-0.039649144,0.035000544,-0.014525496,-0.052907374,-0.0023863183,0.03230989,-0.03960755,0.09318484,-0.062147357,0.008740837,0.036412664,-0.01908363,0.001553926,-0.06139278,0.058413524,0.03969359,-0.038939063,-0.00032069508,-0.017830022,0.050314985,0.07391587,0.04721409,0.01582399,-0.07058561,-0.0025319129,0.0073066344,0.04558812,0.007644267,0.06518638,-0.061027385,0.048401818,0.05875796,0.0048719044,0.019585285,0.07441251,-0.0665402,-0.0037122164,-0.028906014,-0.058109958,0.070747584,0.01554527,0.043830767,-0.04973349,-0.052657142,-0.038212974,-0.04256689,-0.0132288,-0.05582918,0.0034840412,-0.0045509874,0.014311818,0.052856088,-0.0554502,-0.054732103,-0.1269906,-0.07905714,0.10628458,-0.030099213,-0.0052936543,0.0069911415,-0.052360006,-0.0069918493,0.024718303,0.04399479,-0.026352838,0.012263048,-0.010368831,-0.049538683,0.06383017,-0.04822918,-0.08982499,-0.017098315,-0.013261455,-0.012431683,0.0316775,0.018230425,0.04533332,-0.019079398,0.004775011,0.06957838,-0.0044726036,-0.037162233,0.097056255,0.05815862,0.012745,-0.06775121,-0.09097592,-0.059899833,-0.04116797,0.022232262,0.062443644,-0.02816619,0.02228469,0.013383028,-3.563652e-33,0.028947512,-0.10508115,-0.005570851,0.028358264,-0.0046760803,-0.09522696,-0.029544763,-0.029565416,0.0502526,-0.051226724,-0.009549898,-0.01445669,-0.050261855,0.061917517,-0.014280813,-0.06868614,0.03342405,0.0652915,0.019031199,-0.055321895,-0.03153595,0.08121877,-0.044256035,-0.002933003,-0.07169485,0.027506385,0.0348978,0.018500142,-0.02663364,0.020660387,0.019229313,0.06766163,-0.014028991,0.035113435,-0.010663979,0.16014303,-0.036781017,0.0050029415,-0.009706049,0.03589875,0.032787893,0.04224169,0.04198493,0.027635012,0.023536338,-0.019486787,-0.13485083,0.05691018,0.015699336,0.04056701,0.024193645,-0.011061145,0.017416436,-0.020613316,-0.06786603,0.0655641,0.03713143,-0.027679544,-0.00047521706,-0.004461384,-0.077534564,0.024866957,-0.10332552,-0.034377202,-0.06774798,0.06473829,-0.048249234,-0.13149744,-0.041298766,0.007348933,-0.04856812,0.07186108,0.10465695,0.01343301,-0.026524143,-0.031869873,-0.008343833,0.0025128387,0.038236413,0.028410805,-0.082538955,-0.070648,0.005021467,-0.012918414,-0.05318539,-0.03717068,-0.018117303,-0.087141536,0.028504478,0.0003047778,0.003046214,-0.0026267995,-0.013082856,0.013517832,0.024144934,9.410203e-34,0.06064519,-0.09015344,-0.00016247411,0.07630878,0.0016955202,0.0016972793,0.017593024,-0.059376337,0.006480048,-0.006172059,0.05409034,0.012613099,-0.04586257,0.009755057,0.014163692,0.06265526,0.03586969,0.14915788,-0.050093852,-0.022452692,-0.007809981,0.10537847,0.057595864,0.055279188,-0.00055113237,0.01918469,-0.12182069,0.016618855,-0.03714744,0.024911212,0.046318676,-0.015446471,-0.096914954,-0.09233785,-0.03667991,0.015084008,-0.039417446,-0.03418322,-0.16324957,-0.03951207,0.07072077,-0.03238713,0.0036019438,0.042088456,0.04691353,0.053475186,0.0368128,-0.08142516,-0.030857127,-0.0024349235,0.06834582,-0.006349863,-0.031236716,0.115238145,0.050891858,0.07647564,0.016771073,-0.033303864,-0.048606846,-0.01834495,-0.023938177,0.09047865,-0.054949176,-0.10249699,0.047516763,-0.0948283,-0.049289912,0.037805893,0.042324316,-0.010274352,0.09802851,-0.035196993,-0.0021744363,0.0031701108,-0.1015054,-0.06844594,-0.020288344,-0.056133527,-0.029525474,0.0031923163,-0.12290681,0.041496065,-0.04456289,0.03478608,-0.019402094,-0.029181706,0.039802358,-0.062059946,-0.04042199,0.10903591,-0.027969016,-0.008717705,-0.03311204,-0.021040907,-0.015391332,-1.563399e-08,-0.00624079,0.019039672,0.033672046,0.10935283,-0.022586925,-0.04484364,0.07565931,0.06291408,-0.00026702418,-0.032563824,-0.048250943,0.08488452,0.089867465,-0.019961098,0.07370084,-0.053854216,0.004565108,-0.004753142,-0.09699982,-0.052452136,-0.03250634,-0.026539879,0.018821014,0.038670503,-0.045940805,-0.0069937427,0.027389929,0.022770692,0.072227426,0.012266648,0.006229027,0.012939552,-0.028679604,-0.0023086756,0.048138905,0.058232207,0.008116628,-0.053278286,-0.06308185,0.06286205,-0.06625597,-0.0774516,-0.042997908,0.052884266,-0.025202272,0.01961256,-0.028649297,0.075587764,0.0036025813,0.04325933,0.09131136,0.06019893,0.010959175,0.00015150323,-0.032898895,0.04782613,0.02040301,0.00900281,0.057548717,-0.04299816,0.11838406,0.041778225,0.09418136,0.06309318 +1.1.1.55,May be identical with EC 1.1.1.2 alcohol dehydrogenase (NADP+).,384,1.0,-0.07663693,-0.004816828,-0.054356813,-0.023815414,0.06746543,-0.0013432587,-0.09859225,0.06524073,0.040373206,-0.070980966,0.05682612,-0.047077954,-0.11186842,0.022074731,-0.04867965,-0.013823088,0.0022627965,-0.094933234,0.06523033,-0.0017733752,0.020697799,0.053582974,0.02929165,-0.0060242647,0.08661599,0.06988269,0.0069409925,0.11253057,-0.0011783907,-0.094339095,0.055770393,0.018374301,0.015132764,-0.06124933,0.0114540905,0.008068359,-0.029110579,-0.060864747,0.011323379,0.035570387,0.054007705,0.03176415,-0.035584502,0.021797575,-0.061748922,-0.033515245,-0.06658218,0.10816741,-0.012306647,-0.0040936284,0.030142674,-0.03816131,0.0077149807,-0.020107314,0.09764722,-0.030003764,-0.04698761,0.023665836,-0.05802852,-0.0035846345,-0.041582793,-0.013651768,0.030828075,0.058596935,0.055021763,-0.024744034,0.08360864,-0.11388963,-0.011740215,-0.051235087,-0.12896563,-0.07193125,0.04897659,0.07359444,-0.04997403,0.06728576,-0.061849255,-0.038970366,0.02615894,-0.017432677,-0.007078171,0.018425623,-0.06452905,0.015280659,0.02659265,-0.0066747842,0.06675045,-0.05146963,-0.043663498,0.015798986,0.016932486,-0.026097719,0.020602994,0.023810454,-0.07265255,0.075698,0.037264343,0.099207304,-0.009701609,-0.071299605,-0.044120364,0.14086463,-0.0257176,-0.020731352,-0.03000192,-0.013435124,0.011518728,0.05322391,-0.029538611,-0.025376137,0.008920314,-0.05482555,0.040073145,0.006304153,0.008157097,0.055589743,-0.003943601,0.002612584,-0.010144056,-0.016053153,0.032937136,-0.07541783,0.02885049,0.04801349,-0.027389616,0.025619324,-0.0855626,-1.4585106e-33,0.03901821,-0.0106041515,-0.00078583194,-0.014153649,0.043396764,-0.030390667,-0.1029107,0.07466035,-0.0634326,-0.02494744,-0.06696171,-0.026530556,0.047230996,-0.030954309,-0.04630921,-0.025225999,-0.052056473,-0.002565686,-0.013150322,-0.017367207,0.005416528,0.029023375,-0.01351021,-0.004085159,0.036767326,0.03633467,-0.013701039,0.024565041,0.037366476,-0.016164158,0.012115067,-0.06160058,-0.10297525,0.01005848,-0.040233206,0.026985519,0.020461185,-0.06511799,0.015293665,0.034575522,-0.02441555,0.102278985,0.052333046,-0.06645256,0.03881998,-0.075760566,-0.09041983,0.05258399,0.059501495,0.024827236,-0.015166353,-0.0054341885,0.121437564,-0.10157357,-0.0052865376,0.029557824,-0.02081633,0.05246949,-0.01665475,0.08476395,0.018835945,0.10724972,-0.044925217,0.0038320883,-0.01664699,0.023890398,-0.082790874,-0.09312639,0.04256938,0.030937353,-0.007958794,0.039970763,0.11846692,-0.01828581,0.027051536,-0.016052045,-0.020997217,0.03709009,-0.010905563,0.049811345,-0.109036684,0.0059957663,-0.013715002,-0.044220816,-0.0455286,0.03717446,0.0024788536,-0.010922792,0.012999366,0.07416303,0.053677715,-0.013444267,-0.013437014,-0.034031928,0.026131965,-7.859186e-34,0.023873415,-0.06335183,0.036882985,-0.06972934,0.008319908,0.12382529,0.059074152,-0.033583287,-0.0038000825,-0.0073231724,0.13861209,0.034978915,-0.032818753,-0.06492978,0.07531949,-0.019933725,-0.08493587,0.053326875,-0.023260986,0.055545345,0.023804726,0.12721841,0.026613817,0.010955528,0.052053716,-0.012304562,0.00962465,0.026808396,0.012147454,-0.018111931,-0.020098772,0.042568967,-0.08412228,-0.0068731373,-0.017474584,0.034828555,-0.0698355,-0.056963842,-0.019079313,0.006359142,-0.012914246,0.03675408,-0.06758256,-0.0021643857,0.08713601,0.04058022,-0.02840311,-0.040117923,0.06352035,-0.05912181,-0.0073076873,0.066278934,-0.08855625,0.059522048,0.026933666,0.02799011,0.016563075,0.056981597,-0.0060307505,0.007843287,-0.013686679,0.0208452,0.04014326,-0.0016783151,0.007386045,-0.008958505,-0.029187098,0.04946003,0.025527941,-0.032286916,0.091639616,-0.028368138,-0.0049513862,0.023910744,-0.019403426,-0.09303486,-0.057082996,0.019155769,-0.050213814,-0.043327488,0.018779742,0.04080171,-0.049069148,0.0104308445,-0.00054609176,-0.009768858,0.02022321,0.059959725,-0.03150398,0.056529425,-0.0071637672,0.059421904,-0.1449854,0.047834266,-0.0009690137,-2.2136128e-08,0.06147093,-0.031540725,0.07641764,0.011956666,0.04399746,0.021093676,-0.020640822,-0.033819955,0.013203742,-0.0020505108,-0.011193396,0.11076205,0.05372627,0.023847163,0.037452728,-0.025554122,-0.09862832,-0.014176933,0.009670169,0.0038497562,-0.053711824,0.012540867,-0.063342534,-0.008468441,-0.03391335,-0.029277727,-0.03496502,-0.00021235696,0.07119551,-0.0891581,0.018792039,0.057419986,0.066154875,-0.052544065,0.014725219,0.0010288629,-0.03293703,0.044702526,-0.08371139,0.08203042,-0.014907454,-0.15813427,-0.036343247,0.0036970363,0.049470887,0.055004317,0.07298308,-0.028846815,-0.06799103,-0.04785453,0.039211776,0.003062743,0.046290074,-0.061485883,-0.055649124,-0.012183274,-0.0926714,-0.08979246,0.013739302,-0.032296676,0.05996113,-0.035910573,0.1332894,0.020837981 +1.1.1.57,Also reduces D-tagaturonate.,384,1.0,-0.017216811,0.016637187,0.03466078,0.006165919,-0.010916226,-0.0895189,0.047009964,0.073871896,0.0025314768,0.024103556,0.018062564,0.09946956,-0.058877226,0.013082534,0.00016794227,0.054261297,0.006051696,0.119798236,-0.04479616,-0.003037186,0.04161737,-0.007499785,0.05977485,0.038390793,0.018727213,0.002204943,-0.03998606,0.00930763,0.03548456,-0.081089236,0.030201368,0.052838165,-0.065058246,-0.024470858,-0.074372426,0.027016513,-0.0004601377,0.0752764,-0.052824944,-0.002448144,0.06971632,0.058826897,0.005558529,0.02936899,-0.009499298,0.048561964,-0.07835261,0.044794206,-0.04756089,-0.005630466,-0.006974676,-0.0558117,0.030385224,0.054646555,0.008072933,0.08472936,-0.08507766,-0.032151315,-0.008521366,0.06135216,-0.01308364,0.03800067,-0.019155202,0.021881854,0.057265468,-0.0054309657,0.034582417,-0.02983505,0.012787425,0.059751723,0.075432315,-0.030812321,0.020452742,0.007981909,0.0318577,-0.006425686,-0.015794229,-0.09382222,0.1089228,0.00031415964,0.0012073067,0.035375126,0.00898014,0.0712546,0.016718624,0.008798591,0.010425651,-0.147857,-0.10113428,-0.012532472,0.037953258,-0.056612406,-0.051517744,0.017683866,-0.13693099,-0.055464853,-0.016115656,0.0200047,-0.08826284,0.06550098,-0.0016698439,0.0063427947,-0.098008126,-0.04792741,-0.0601377,-0.03260415,0.04842816,0.002265264,-0.02950434,-0.05244957,0.03817259,-0.010915794,-0.010247249,0.08600724,-0.10728396,0.048617702,0.06721832,0.026159085,0.011859825,0.005148532,-0.07066817,-0.036508583,-0.022335492,-0.08205326,-0.028922543,0.010257274,-0.06253446,-5.4807254e-34,0.0037096848,-0.016949454,-0.027512256,-0.076109864,-0.008547493,-0.0056260363,-0.12777969,-0.055495393,0.018041113,-0.033377826,-0.03359301,-0.10252754,-0.010357659,0.08787695,0.03738572,-0.08587383,0.007006995,0.040778246,-0.04556861,-0.09294738,0.039534464,0.040272262,-0.02498268,0.005565064,0.031206802,0.022543162,-0.030026803,0.00092430075,0.056803748,0.046175033,-0.05538923,0.030487757,-0.040798724,0.017804494,-0.0364867,0.12794112,-0.039402958,-0.058015887,-0.010381206,0.0019995118,-0.04403752,-0.0104606245,-0.039182045,-0.078605026,0.018368797,-0.023874663,0.037244335,-0.001408029,-0.06791581,-0.01878069,0.09002316,0.018844826,0.05702605,-0.06671973,-0.03874198,0.018610997,0.028368635,-0.08905394,0.09073571,0.07823176,-0.108533494,-0.055165783,-0.017816035,-0.019458905,0.039509077,0.011779945,0.011842191,-0.04212976,-0.08767736,-0.041538797,-0.06030006,-0.02606641,0.036551487,0.0049659344,-0.018989092,-0.032236118,0.031175345,-0.02339902,-0.0128840525,-0.05011213,-0.006926943,-0.047778964,-0.04918381,0.043298386,0.06927744,-0.063956626,0.037238687,-0.08701387,0.07302159,0.006339358,0.027543038,-0.016611889,-0.07722286,-0.04810141,-0.02657071,2.0037796e-34,-0.060108695,-0.039814744,-0.024330933,0.09009405,-0.017578682,0.040438816,0.06796345,0.09592854,0.010444548,-0.09545374,0.056437355,0.020682242,-0.16034262,0.0041390364,0.055992104,0.049573824,-0.022713874,0.04147236,-0.0067040934,0.021181723,0.059365053,0.090553455,-0.015471306,0.1000017,0.052923366,-0.001257951,-0.080617286,0.03341166,0.07467578,-0.00039208462,0.011744787,0.0009209228,-0.0883593,-0.07436547,-0.016819142,0.039683018,0.013898523,0.043195095,-0.04845637,0.020052778,-0.017593881,0.0059373314,0.0980558,0.08377412,0.027763624,0.00095074094,0.004035576,-0.03001658,-0.024785783,0.080396526,0.017286927,-0.033556502,0.0058367928,0.010843763,-0.030355964,-0.040656447,0.08798771,-0.059837442,-0.09806217,0.038032364,-0.03732883,-0.0334435,0.023634987,-0.050340854,0.09592313,0.0011245267,-0.025273323,0.11001259,0.044728298,-0.0034423694,0.13816282,0.07918518,0.022116432,-0.006165604,-0.034463283,-0.03629501,0.008552552,0.025385864,0.014483815,-0.025244227,-0.046848204,-0.02606055,-0.015675804,-0.0069652707,0.013872426,0.021870576,-0.021954628,0.033135884,-0.07409182,0.0770679,-0.028318044,-0.027790807,0.035454534,0.085610084,0.004590556,-1.5630594e-08,-0.008185983,-0.02875231,-0.01979294,-0.0025034274,0.0044914507,-0.097900264,0.061228964,0.10995754,-0.031503856,-0.051615294,0.033600695,0.09668531,0.050033435,0.03861951,0.056444485,0.011269021,0.056513842,0.05714287,-0.09452988,-0.033485204,-0.055532325,-0.031579893,-0.025469584,0.04556443,0.0025685371,-0.03154301,0.1059307,0.07752256,0.04269515,-0.008302489,0.045986354,0.00553201,-0.0135226995,0.019354137,0.045746077,0.059057437,0.024543509,-0.04305852,-0.0071022664,0.0947022,-0.049877875,-0.036041316,0.022759775,0.067928165,-0.014122721,-0.09041499,0.026164416,0.019324224,0.0033909336,0.027037201,0.018218085,0.02599752,-0.0094809905,-0.053765517,-0.06281788,0.05191817,0.026803583,0.011854484,-0.0014573089,-0.02905597,0.039016757,-0.02772313,0.045289014,0.039636035 +1.1.1.62,"The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase [3]. The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20alpha-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+.",384,1.0,-0.009339353,0.0009036796,-0.01991603,-0.032920565,0.031609837,0.021921286,-0.0709653,-0.0077617182,0.017446632,-0.0056485343,-0.016160972,-0.0153329,-0.1085713,-0.019430118,0.014862277,0.023618817,-0.06861674,0.037082933,0.045392964,-0.05001259,0.071819216,-0.04340024,-0.0344594,0.01162368,0.014401955,0.015813861,0.08074263,0.04770001,-0.09874952,-0.105363145,0.013729282,-0.03916733,0.060159322,-0.016098501,-0.03732452,0.07046369,-0.11101193,-0.12291356,-0.0011026745,0.06249446,0.029116206,-0.06005611,-0.055011787,-0.039133765,-0.007373361,-0.05244053,-0.053586654,0.04032185,0.011313573,0.01533819,0.054508436,-0.07461494,0.01490588,0.038733475,-0.02343517,-0.03999082,-0.041120514,0.062070537,-0.048235565,0.01768422,0.0106877,-0.030320289,-0.024603453,0.051694248,0.015776321,-0.026284033,0.06753734,-0.09857635,-0.04414006,-0.021003647,-0.051190857,-0.07147784,-0.0033925008,0.0636321,-0.03602062,0.017508848,-0.036528606,-0.064299114,0.06929823,-0.039748553,0.043666843,-0.007224341,-0.0077602207,0.06995024,0.08449253,-0.01929435,-0.03213979,-0.029700935,-0.010080776,0.055807795,-0.04657254,-0.022500716,-0.0045363745,0.05598953,-0.0072009773,0.08350047,0.01235153,0.08924492,-0.02389944,-0.05727233,-0.017869834,0.14354831,-0.08408413,-0.004109498,-0.023585131,0.05725912,0.039704114,0.098819934,-0.03830165,0.008893528,-0.011184488,-0.036626387,0.0511491,0.013142544,-0.015192779,0.09401388,0.05421192,-0.040828135,-0.008756475,-0.061189245,-0.002182393,-0.026532846,0.055200808,0.043937575,-0.019316943,0.0979732,-0.06913207,3.0458753e-34,0.08461413,-0.017526602,-0.032830175,-0.008934875,0.017040122,0.06865753,-0.031404056,0.073461376,-0.05172404,-0.07170331,-0.06923494,-0.003340403,0.091539614,-0.004410925,0.014342348,-0.03179912,0.036555503,0.004874873,0.071520515,-0.004369854,0.026194377,-0.00035208047,-0.07100206,0.006449904,-0.03570647,0.011326084,-0.054904167,0.04708024,-0.018716006,0.016837083,-0.057404142,-0.09395766,-0.05371872,0.010447432,0.010629339,-0.043505143,-0.020531205,0.00069853093,0.018334223,0.08606117,-0.02008649,-0.02207479,0.04094011,-0.09737159,-0.002623569,-0.019336855,-0.020046724,0.09176191,0.08259144,0.0630678,0.031024627,-0.00798663,0.070109054,-0.036553316,-0.044634376,0.067868195,-0.035975877,-0.030964835,-0.023512863,0.057153627,-0.013022786,0.09109772,0.020763,0.051542323,-0.005447986,-0.017588928,-0.045627266,-0.037261564,-0.056143265,0.07595628,-0.0829327,0.04618628,0.10148158,-0.03201145,-0.007284969,0.058186512,0.005154751,0.041341115,0.024156403,0.024635574,-0.0070589143,0.037443116,0.020202614,0.001159329,-0.011712396,0.011455487,0.0067915325,-0.03605723,0.062162608,0.03949946,0.03657356,-0.08810747,-0.07237221,-0.021546265,0.013920021,-2.3931465e-33,0.06954551,-0.046756297,0.026309578,-0.11183843,-0.026929706,0.121238865,0.08501544,-0.051644012,0.04794364,0.0072551407,0.05092651,-0.014968997,0.020010903,-0.13910994,0.07222452,-0.042518344,-0.13437153,0.006642539,-0.053875916,-0.07216085,0.046395823,0.105334885,-0.024753164,0.0828784,0.050286643,-0.033823684,-0.028859867,0.01380173,0.06354751,0.065229006,-0.03322558,-0.011226348,-0.00064692565,0.025647396,0.07718029,0.06688598,-0.09916244,0.02012626,0.0580148,0.012872333,-0.06134167,0.036810886,-0.009395372,0.026740061,0.100447,0.09364821,-0.028508944,-0.0037181366,0.026195813,-0.03840793,0.014183058,-0.0062550735,-0.04328351,0.022712715,-0.0067158877,0.0025550427,-0.035400085,0.0038313617,0.007786774,0.00372539,0.013706815,-0.050411828,0.04612726,0.015371556,-0.071883604,-0.026634464,-0.06109683,-0.018612472,0.030330945,0.050003804,0.046637107,-0.056180406,-0.0053311246,0.0564231,-0.014849342,-0.09847479,-0.060409803,0.009107732,-0.044509735,0.010581115,0.044576798,0.036395095,-0.032754607,-0.062764846,-0.011973863,-0.015344105,-0.01361574,0.086411424,-0.0055190143,0.047775712,-0.054779038,-0.008496492,-0.1212077,0.03145641,-0.010596096,-4.3539334e-08,0.030098042,-0.013974272,0.086503915,-0.017941548,0.017186858,0.02142224,0.050394014,-0.0012787043,0.09175334,-0.04942723,-0.004034572,0.091887325,0.038698982,0.027887266,0.05211951,-0.052559506,-0.015406026,0.046833035,0.00012593222,-0.006567761,-0.034764983,-0.052427888,-0.11543301,0.008084357,0.044820506,-0.045961615,0.0024272506,0.045411058,0.018553289,-0.022936787,0.017625276,0.008863683,0.039229933,0.015198939,-0.048186477,0.04783293,0.00049185887,0.021705274,-0.048706666,0.03304224,-0.02466655,-0.12679327,-0.022754878,0.045246128,0.00841024,0.019976355,0.029043384,0.02154729,-0.015097473,0.007671714,-0.021213982,-0.024854317,-0.03370476,-0.048162825,-0.057492163,-0.002845089,-0.05096459,-0.13074085,0.01390095,-0.10069825,0.053278185,0.01554821,0.20261447,-0.014990821 +1.1.1.64,Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.,384,1.0,0.0006398221,-0.084856495,-0.006640809,0.04221747,-0.025405131,-0.032975294,-0.005801209,0.003820292,0.012502026,-0.04276383,-0.027792767,-0.020419508,-0.022068845,0.03835992,0.037260503,0.12056395,-0.036389332,0.0513631,-0.010168701,0.038591795,0.08707193,0.004617815,0.052737817,0.011760522,0.0033685146,0.062099602,0.051839363,0.0023871355,-0.013944969,-0.0695464,0.0012337405,0.08074517,0.034508232,-0.07575363,0.0032195412,0.028530102,-0.0693367,-0.07098133,0.025995549,0.010263606,0.06227828,-0.001463738,0.0035167658,-0.013307683,-0.019304099,0.0252459,0.03718368,0.005488865,0.046608515,0.035687055,0.02484096,-0.09841077,-0.058106277,0.10990661,0.013605907,0.019999819,-0.046464946,0.038203683,-0.03150849,0.030036211,-0.041757457,0.06255354,0.046592508,0.05669074,0.057218432,-0.06456252,-0.036255356,-0.08239935,-0.079610825,-0.002576546,-0.056882303,-0.08292787,0.04084879,-0.0055756536,-0.05107207,-0.015023689,0.053322796,-0.050060734,0.06113958,-0.028251642,-0.07559983,0.003910265,0.022851905,0.1388648,0.057031497,-0.031125467,-0.037467,-0.13267925,-0.08625974,0.05709512,-0.042071722,0.014790896,-0.0069761984,0.0014661725,0.039339285,-0.07381524,0.048415262,0.05741315,-0.057478324,0.0035782817,-0.01771634,0.056381628,0.01909989,-0.040941212,-0.052420996,-0.00034422532,-0.013970065,0.034444537,0.032968532,0.044182874,-0.042387232,-0.0046607396,0.062135532,-0.037380803,-0.06552492,0.11354006,-0.015575583,-0.0095507,0.013811497,-0.038799744,-0.016133996,-0.08504962,0.0388647,-0.04284494,-0.08658718,-0.0060297507,0.014522653,3.0180142e-33,0.025479076,-0.034069113,0.016855745,-0.028576838,-0.023907598,0.022194296,-0.070755154,-0.047276683,0.06755445,0.013752304,-0.047147963,0.04358939,0.07051993,0.084527016,-0.022099348,-0.052101314,-0.12332264,0.03183462,0.028342677,0.025130095,0.03162202,-0.016330596,-0.046708878,-0.017367477,-0.071989015,-0.016003016,0.0026955153,-0.019142445,-0.0070158313,0.024535311,0.0069910004,-0.006298396,-0.08927323,-0.03846535,-0.10696899,0.016237102,-0.012019937,-0.054004814,-0.035067357,0.072388135,0.0028601792,-0.03297484,-0.023585873,-0.07221488,0.0747964,-0.050172962,-0.079977065,0.056546934,0.03294087,0.029308615,0.039210454,-0.074037544,0.079569176,0.0063478695,-0.0077987206,-0.006403825,-0.016576475,-0.031000441,0.027296951,0.019445114,-0.01479265,0.052934047,0.011093999,0.029034354,-0.017790124,0.046156082,-0.0007839797,-0.029198922,-0.087202035,-0.013075944,-0.06787855,0.067097396,0.11273259,0.007812963,-0.05629995,-0.009536673,-0.057003178,0.06945206,0.059499417,-0.008344057,0.07104047,-0.059596673,0.08150291,0.027839527,0.0006397936,0.036335405,0.011546112,-0.07748306,-0.048224475,0.03608209,0.10639501,-0.0682148,-0.094228424,-0.029039249,-0.007645721,-4.534635e-33,0.033773847,-0.08293247,-0.025567109,-0.063965425,0.03462041,-0.0014210346,0.018235737,0.078823276,-0.0033206479,-0.060417764,0.06430648,0.035117738,-0.020835077,-0.097368136,0.08234561,-0.013744542,0.029525053,0.021502357,-0.04911216,-0.02221353,0.12743407,0.025223041,0.015159226,0.028158449,0.012810651,0.023546288,-0.024109544,-0.031821396,0.029221162,0.093851835,-0.004400089,0.022813816,-0.042270314,-0.044527244,0.005349713,0.022057017,-0.08784016,-0.00038288938,-0.025420899,-0.08847808,-0.011607382,0.0026194616,0.05978973,0.08913628,0.07633598,0.09214254,-0.0929932,-0.07845241,0.0278832,0.04741357,7.94996e-05,-0.022819752,-0.03855575,0.0010347279,0.014754106,0.05516489,-0.054944932,-0.09005444,0.05348065,0.00562262,-0.07701055,0.036830965,0.11006511,-0.060605586,-0.036628507,0.05153337,-0.04409442,0.040379204,0.090875275,0.024987157,0.09318287,0.019374033,-0.051678155,0.02870607,0.0070157573,-0.029158497,-0.023665981,-0.015367495,-0.06003294,0.034426212,-0.026558585,0.028834285,0.037264083,-0.024194533,0.010441195,-0.055855278,-0.064274676,0.0520732,-0.036332976,0.023111627,-0.040731963,0.0050608697,-0.05309856,0.0051900325,0.06106738,-2.6681564e-08,-0.04221077,-0.0818706,0.10346426,0.024871256,-0.032946073,0.04563425,0.01240006,0.050706867,0.03130369,-0.112280525,0.060905892,0.10468154,0.040033553,0.00011698547,0.07943266,-0.05485068,0.03528308,0.004273996,-0.028722057,-0.09751594,-0.09146444,-0.060290184,0.07697002,0.038597904,0.027423365,-0.024859942,-0.0056087095,-0.01046303,0.009833297,-0.017930955,0.027279748,0.08366285,0.007626038,0.0074010002,-0.08211491,0.006213272,0.022142824,-0.010177379,-0.08434757,-0.021883914,-0.0727405,-0.08054296,-0.015108828,0.04626629,0.08641171,-0.03945924,-0.012070468,0.015211403,-0.011034557,-0.097135365,0.03763463,0.007499506,-0.034493197,0.023090046,-0.07574829,0.021882426,-0.051082697,-0.03542856,0.01945238,-0.023113204,-0.011998321,0.010025228,0.15765548,0.0122878235 +1.1.1.65,Also oxidizes pyridoxine phosphate.,384,0.99999994,-0.031303387,-0.03205153,0.0011799302,0.0018212389,0.046478026,-0.028882103,-0.0042705433,0.043736536,0.025860686,0.002701112,0.042179607,0.08601273,-0.031165944,0.1131086,-0.04259971,0.024202468,-0.046934813,0.14388254,0.012645389,-0.049423378,0.0811248,0.04439998,0.023818027,0.039100416,-0.0011916582,0.051126096,0.051293395,0.036303263,-0.023806632,-0.031213762,-0.03991759,0.025313916,-0.04728223,-0.08856165,-0.0016820421,0.11040418,-0.07938728,0.05213272,0.011308767,-0.014916217,0.019704448,-0.071609125,0.021642882,-0.018516315,-0.006997351,-0.008602834,0.027631285,-0.0102546355,0.036981482,-0.018037353,-0.073151305,0.0031579873,-0.02787674,-0.031784594,0.037930414,-0.021341516,-0.030228764,0.047054287,-0.022903696,-0.030548627,-0.018753702,-0.03539707,-0.02033129,0.025683591,0.044093937,-0.056743275,0.043903753,-0.015083729,-0.04447188,-0.045918316,0.01835222,-0.034263693,0.07126922,-0.00080212695,-0.012629261,0.070291616,-0.059277613,-0.05985256,0.005655223,0.06669408,0.021879878,-0.009954909,0.019832116,0.103876315,0.09777633,0.025256744,-0.024248019,-0.07627214,-0.10079601,3.2438933e-05,0.010021249,0.038117435,0.009209532,0.035146307,-0.053151414,-0.003883312,-0.02792688,0.039468072,-0.07693405,-0.018611444,-0.06862817,0.07138677,-0.100874156,-0.032504965,0.0023883611,-0.028417414,0.018227886,0.027201977,0.023948645,0.018584158,-0.026555084,0.05891348,-0.03899883,0.009849191,-0.0016170547,0.06057118,0.058651432,0.040150683,-0.081288226,0.055288542,0.008596617,-0.065811135,-0.04110008,0.013746145,-0.057288267,-0.045790527,-0.014256089,1.9026195e-33,0.038236216,0.06996293,0.015979618,0.023711031,0.039281495,0.015083658,-0.071955346,-0.08662698,0.038920756,-0.023632638,-0.025186205,-0.003408567,0.02153508,-0.0056922287,-0.020441586,-0.06508789,-0.101911664,0.048337847,0.078472786,-0.03791531,0.09888942,-0.008572172,0.0022577906,0.07320246,0.00061830453,0.037906826,-0.012855062,0.0041281953,-0.049800806,-0.010474812,0.04192624,-0.047648247,-0.11167098,-0.021440508,-0.030681098,-0.02681144,-0.11820762,-0.08844658,-0.03748804,0.04356714,-0.08729367,-0.02374224,-0.057610817,0.0064076944,0.045557577,-0.117214546,-0.06604776,0.1280669,0.019521909,0.048170187,0.029235072,-0.048055712,0.054951202,-0.023458645,-0.04323616,-0.03207832,0.020387039,-0.14067696,0.020899989,0.04793166,0.041702434,-0.009815099,-0.038637567,-0.004731864,0.02501209,-0.033107076,0.014947509,-0.052460697,0.013234839,0.050086644,-0.0217947,-0.017297138,0.058101196,0.021296386,-0.11340479,-0.023852766,-0.040151026,0.013815547,0.014858063,0.00047035038,0.0376495,-0.112780586,0.012539085,0.00435678,0.0048563704,-0.0020496931,-0.0040129577,-0.04736236,0.0360664,-0.008020764,0.08561037,-0.09567619,-0.06755192,-0.05286555,-0.04583017,-1.7727663e-33,0.07274517,-0.035478946,0.03658857,-0.0040966272,-0.03954578,-0.011425602,0.043029584,0.020639736,0.06358796,-0.03488815,-0.018076466,-0.00886352,-0.008540309,-0.012599326,0.021334302,0.04748505,0.03508073,0.057477206,0.03188733,-0.004817037,0.01325342,0.07851735,0.016047841,0.09313907,0.08835369,0.034957558,-0.06506091,-0.010569752,-0.008152459,0.07466126,0.016138176,0.0026910268,-0.07006891,-0.044396054,-0.027590547,0.053829018,-0.044865165,0.022301076,0.0001892159,-0.00011639973,0.07108027,0.016814714,0.07997265,0.04539266,-0.033643458,0.044376303,-0.013189541,-0.009826764,0.005916285,-0.022978934,0.07567052,0.06820864,-0.05101129,0.0031303456,0.06609595,-0.014728333,-0.02896908,-0.060209457,0.023563903,-0.00028917866,0.012426136,-0.042294517,-0.029063093,0.025326038,-0.009734815,0.06470726,-0.0023490905,0.032835137,0.0765877,0.056320112,0.08646767,0.009481529,0.06615402,0.0014425962,-0.05991374,-0.03050371,-0.048259076,0.059527516,0.004926795,0.012964379,0.0057813213,0.0008215356,-0.024116848,-0.08234807,-0.014663749,-0.06161791,0.021463143,0.092465766,-0.034266744,-0.009308775,-0.034921397,-0.021659775,0.036435805,0.04725442,0.032781538,-1.8796948e-08,0.022223743,-0.044635706,0.10102248,-0.049596142,-0.026777226,-0.037452802,0.1186948,0.084466614,0.039355125,-0.044724923,-0.0014269814,0.07592166,0.11220837,-0.026955644,0.109623685,0.02352067,0.019869994,0.06785393,-0.04514285,-0.06875444,-0.09363074,-0.012387209,-0.039489865,0.046358336,0.033982117,0.007921613,0.04942059,-0.010994271,0.050465308,0.0016532086,0.043733098,-0.043831747,0.049723122,-0.0797481,-0.06605045,0.05391913,-0.0099420715,-0.01992665,-0.051399007,-0.021178242,-0.13243611,-0.07374225,-0.0311721,0.0489354,0.017231284,0.0079053035,-0.047217086,0.04369581,-0.04963219,-0.021837257,0.09707251,0.012650313,-0.04118061,-0.08696523,-0.15734726,0.06658609,0.07269631,-0.022349203,0.016590044,-0.09622716,0.010688053,-0.016617369,0.18310978,-0.061530866 +1.1.1.66,"Also acts, more slowly, on 9-hydroxynonanoate and 11-hydroxyundecanoate.",384,1.0,0.021799145,-0.12440605,0.015707495,0.010444923,0.011830374,6.943285e-05,-0.04303091,0.043318056,0.005521184,-0.07351134,0.030712012,0.01184405,-0.036293477,0.048237275,-0.030436508,0.0524779,0.028529832,0.025005942,-0.020589018,0.025997883,0.07081118,-0.04771498,0.064646274,0.032848265,0.030872408,0.035517905,0.0075115426,0.029233508,-0.012194872,-0.07722748,-0.028363954,0.03222863,-0.017614212,-0.048938684,-0.004815435,0.057300884,-0.04761762,0.024576982,0.052126832,0.049881287,0.051660188,-0.086135514,0.047544125,0.021237817,0.0046710414,-0.011687056,0.0020603992,0.009732282,-0.002592376,0.044654008,-0.06868319,-0.1002275,-0.08868781,0.057859782,0.011394235,-0.03543447,-0.093099415,0.064124025,0.036153823,0.004366867,0.002685354,0.039409913,-0.011538967,0.051316362,0.045096032,-0.012948862,0.021007614,-0.08357298,0.0048219147,0.013959039,0.088755466,0.03595096,0.02220506,-0.03031793,-0.022673447,-0.04416455,0.00042818155,-0.04263267,-0.02275876,0.0051294724,-0.03304988,0.05446897,-0.015971022,0.0386281,0.008848634,-0.02280062,0.021193279,-0.062301163,-0.110768,0.032185372,0.053398136,0.060139112,-0.03590318,-0.05183373,-0.024804749,-0.023004742,0.04287897,0.015198352,-0.018339628,-0.0023567674,-0.061921168,0.033579722,-0.09958049,-0.06987641,-0.017239999,0.023130598,0.041581977,-0.0007840746,-0.017595576,0.023181427,-0.032123037,0.009871951,-0.029470993,0.052636158,-0.088036746,0.08082207,0.01570905,0.015136997,-0.040251408,0.019293686,-0.029191203,-0.07416638,-0.0046769916,-0.002507312,-0.08200914,0.054727245,-0.009252754,2.6639462e-34,0.081295915,-0.048271503,-0.013078204,-0.02079309,0.0076513565,0.019264137,-0.13220258,0.009327232,-0.011571443,-0.04113234,-0.044731267,-0.030800464,0.0034380734,0.02046997,-0.074392974,-0.10893989,-0.020472277,0.056642342,0.00032310162,-0.064672306,-0.008347271,0.032174367,-0.094042294,-0.0026393603,-0.094136946,0.008631315,-0.037056863,0.0758651,-0.006349128,-0.017666725,0.015556105,-0.023726193,-0.056367315,0.010499607,0.029230986,0.057810783,0.016306454,-0.048205532,0.06252208,-0.033566274,-0.058890607,0.033366602,-0.038889952,-0.036798432,0.07179611,-0.03871929,-0.05038091,0.08277845,0.07551337,0.028880283,0.057589125,-0.014732257,0.07756742,-0.01460079,-0.0018612449,-0.022873495,0.05280285,0.00029477448,-0.023134034,0.107361525,0.03509306,0.026301015,0.0059030075,0.009422628,-0.010654074,0.04507156,-0.054240137,0.028460344,0.04330254,-0.032361645,-0.013048522,-0.00628787,0.12591894,0.01672523,0.07797883,-0.03169145,0.018945253,-0.024333864,0.036532443,-0.021189606,0.052979033,-0.072474696,0.036183033,-0.011035041,-0.0484828,0.08764485,-0.022784311,-0.058137923,0.006869464,0.07776187,0.037161175,-0.10751082,-0.04401952,-0.037760165,0.014073997,-1.5235075e-33,0.028007112,-0.10574384,-0.011418219,0.023481954,-0.03287108,0.06389948,-0.018133154,0.0041248137,-0.02230644,-0.016233975,0.11493459,-0.046000525,-0.0422951,-0.03578755,0.0024611366,0.054922916,0.056441635,0.073736645,0.020255696,0.008709453,0.022776019,0.11734809,-0.018039372,0.08751645,0.020356057,-0.00029056694,-0.012680555,0.026479177,0.027188826,0.0689319,-0.07640067,-0.061187554,-0.1246092,-0.020108929,-0.03662129,0.06299628,-0.06297093,-0.011544953,-0.03621688,-0.018820625,0.013011931,-0.090761,0.06210085,0.06191719,0.031922054,0.07709338,-0.060934737,-0.015043952,-0.07805558,0.08996716,0.023556426,0.001401181,-0.07784476,0.08829476,0.058478095,0.07968558,-0.034937087,-0.07566003,0.0025159388,-0.00045400835,-0.015894258,0.006790398,-0.043633062,-0.074155934,0.031903926,0.055715106,-0.044894233,0.065106526,0.10353524,0.013954934,0.075262904,-0.017296704,0.004553982,0.039811976,-0.05747408,-0.10569663,0.08079537,-0.0977823,-0.049433984,-0.043864354,-0.011095733,0.03388328,0.0159807,-0.101692356,-0.0696711,0.012647385,-0.0020964092,0.032715898,-0.020284366,0.13339236,0.03756918,0.051952727,-0.014346395,-0.016380602,0.039313126,-2.6472366e-08,0.003049652,-0.06155692,0.13450181,-0.0011267352,0.029471833,-0.022806505,0.07099543,0.061347816,0.018897707,-0.077566914,0.02959995,0.062324468,0.054593716,-9.0278394e-05,0.045363184,-0.06636089,0.016271744,0.036834415,-0.055308618,0.017158078,-0.1734073,-0.032326344,0.043421134,-0.03706236,-0.04327688,-0.015174674,0.025937416,0.10787588,0.0023403284,-0.040318638,0.05748807,0.027577436,-0.053554345,-0.060920756,-0.07059639,0.08136868,0.028193416,0.022167834,-0.019620936,0.00012507082,-0.08308973,-0.07981233,-0.061548874,0.06927606,0.015328853,-0.046756342,-0.02049455,-0.014833905,0.053452145,0.022282887,0.0912435,-0.0031053016,-0.0050576655,-0.053287636,-0.059391316,0.016363233,0.015515922,-0.03427268,-0.021321535,0.026069134,0.0019376231,-0.0019370111,0.14677231,-0.041455004 +1.1.1.71,"Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol.",384,1.0,0.03757463,0.057123855,0.049046602,0.04100519,0.04165816,0.09090983,-0.014546937,0.056846417,0.0011986985,0.02812573,0.031219527,-0.02555817,-0.056866657,0.02502828,-0.03771178,0.037957124,-0.03566042,0.07361503,-0.06361827,-0.06281968,-0.011145413,-0.07463728,-0.00031843092,0.043740638,-0.020150296,-0.043751016,0.018663837,-0.03541411,-0.0066926433,-0.090358816,0.01575434,0.00917509,-0.00076510647,-0.033663087,-0.018859396,-0.009921839,-0.001731525,-0.037113078,-0.045623973,0.05744879,-0.014965435,0.034665987,-0.050530393,0.038372975,0.09763447,0.008637274,0.0557463,0.06401172,-0.016233215,-0.015489643,-0.031632945,-0.007999739,-0.11599645,0.00828911,0.048517823,0.024043815,-0.15644579,0.030073479,0.085693516,0.05389664,0.064067364,-0.097852975,-0.010525202,-0.004894719,-0.06477827,-0.040874276,0.047424853,-0.0785834,0.02490318,0.069183685,-0.07135758,-0.03465724,-0.031473093,0.008941739,-0.032474693,0.0039643706,-0.006407241,-0.15314701,0.048103794,0.0017367868,0.02030282,0.04834608,0.0017935373,0.097156614,0.08798952,-0.011254728,-0.0047924225,-0.076366894,-0.07737957,0.04283382,0.02378572,-0.0067702765,-0.045286603,-0.031763032,-0.10341225,0.012718573,0.10543329,0.020952225,0.0054221563,-0.003941289,0.02384872,-0.03158966,-0.053735632,-0.069232024,-0.106248535,0.029116206,0.08602515,0.09293568,-0.0014851363,-0.0021718594,0.02353068,0.06949044,-0.09375075,-0.01841799,-0.039472573,0.0711258,0.07827918,-0.075916305,0.060496353,0.017333817,-0.020749805,0.019957464,0.08448874,0.011386165,0.0066066263,-0.024544101,0.009817826,4.1314674e-33,-0.00530547,0.05122437,-0.019542374,0.0051497174,0.10315587,-8.184043e-05,-0.07839198,0.029217998,-0.06332351,-0.03759626,-0.010617066,-0.06284812,0.031188972,0.01973392,0.05241146,-0.037109885,-0.048707813,-0.03125053,0.0037506253,-0.11148569,-0.09654681,-0.02187462,-0.012393954,0.052436747,0.049923647,-0.03765562,-0.0018927703,0.014165194,-0.041793764,-0.020145686,0.033505417,0.111672625,-0.07877424,-0.010646448,-0.0033566456,0.04276269,-0.010181289,-0.053075362,0.0067282347,-0.021698568,0.017699454,0.106516056,0.013625666,-0.09316641,0.056989446,-0.011099134,-0.06502405,0.10342525,-0.031083906,0.044540748,0.09181793,0.050651446,0.020132404,-0.06211444,-0.04196399,0.038661752,-0.07755048,-0.025722621,0.013864412,0.03984013,-0.00089227036,-0.006590428,-0.007014817,0.05313357,0.029944496,0.014870823,-0.033003047,-0.023794603,-0.060868245,-0.07538478,0.0020599714,-0.00041789995,0.099590786,-0.038453624,-0.0076742023,0.025557293,-0.097801186,0.04445545,0.029191522,0.009071672,-0.023065817,0.03131998,0.09053121,-0.07973785,0.0073569855,-0.08410742,0.014908584,0.008998004,0.057502702,-0.053363394,0.04148781,-0.06459016,-0.014993379,-0.011234886,-0.009313767,-4.4845084e-33,0.038490847,-0.07931331,0.0779707,-0.032949913,-0.044204626,0.006072883,0.019439323,-0.028077539,0.010153038,-0.08820355,0.110313654,0.012428543,0.03315191,-0.0041845706,0.016863778,-0.022312745,-0.0170999,-0.0020107187,-0.02896795,-0.02327868,0.0042673904,-0.018279513,-0.050710633,0.013585155,0.023816638,0.056332182,-0.027743611,-0.030223582,0.05707197,0.012662308,-0.032440394,-0.009053317,-0.007824545,-0.037536398,0.030091932,0.012955798,-0.07236027,0.04235695,-0.056533817,0.100168295,0.041351695,-0.025826497,0.044304438,-0.008177194,0.056071594,0.055612337,-0.01641616,0.00049140304,-0.02867698,-0.003038711,0.04552115,-0.006017175,-0.050567675,0.0029547699,0.009425228,0.017344266,0.011858415,-0.05602745,0.11117736,-0.0149697745,-0.052164078,-0.0600357,-0.016370337,-0.06477722,0.024187414,0.042616148,-0.042310424,0.06907783,0.055514064,-0.090189554,0.11058239,-0.010318457,-0.025696002,-0.0031354465,-0.069863476,-0.091125086,0.061956916,-0.0028074575,-0.090707645,0.066444024,-0.014893175,-0.056997653,-0.039139636,-0.0071508745,-0.003306283,0.018338496,0.0057683312,0.028155908,-0.036275443,0.049029324,-0.06397861,-0.025522452,0.014317918,0.028233623,0.015077987,-2.8006369e-08,-0.0036427318,0.0056528384,0.05048693,-0.0171028,-0.022332676,-0.019765,0.029899988,0.16741018,-0.020199263,-0.064515755,0.012099018,0.08455137,0.05611745,0.09274069,0.05992279,-0.029598994,-0.009875469,-0.024099305,0.02004569,-0.021488164,-0.12807973,-0.015951166,-0.0070698187,0.04610831,-0.109501466,-0.03588087,0.08169808,0.06063386,0.0012358888,-0.030075539,0.086018875,0.08659508,0.07480463,0.0022564086,-0.044793654,-0.040159527,0.012256243,0.013551784,-0.048988238,0.09445045,-0.057798583,-0.07636773,-0.01520957,0.04785104,-0.011470367,-0.08482732,0.06635734,0.009243183,-0.04755025,0.023234474,0.029460445,0.0033196653,-0.015119588,-0.04451564,-0.082451485,-0.05488846,0.08294826,0.012816784,-0.01599341,-0.08364791,0.035780113,-0.0056754905,0.049523026,-6.188881e-05 +1.1.1.73,"Acts, less rapidly, on other long-chain alcohols.",384,0.99999994,0.051564775,-0.10780238,0.020535696,0.075939685,0.06708099,0.013359743,-0.05370186,0.05000046,0.07278145,-0.06268907,0.05926392,0.07570895,-0.08013211,0.12918319,0.0307813,0.026000503,-0.008358422,-0.04327462,-0.04352546,0.031079846,0.069385506,-0.050444935,0.04874066,-7.510067e-05,-0.026806409,0.043909207,-0.02084114,0.016716814,0.04070656,-0.10090523,0.0062209032,0.061979108,0.00024997487,-0.026590548,-0.04857862,0.03686938,0.01067067,0.052897133,0.066891365,-0.07206989,0.10265928,-0.043001335,0.0068037165,0.025073597,-0.032792985,0.017977456,-0.0395789,0.0035413813,-0.024307923,0.0019861364,-0.03221101,-0.07995206,-0.015158645,0.031557348,0.06603893,-0.032578643,-0.059991166,0.03577192,0.011132379,0.02989116,-0.038787708,0.04690601,-0.01129285,0.08204441,0.035489246,-0.02745962,0.06455165,0.025074048,-0.033181448,0.047728505,-0.005917258,-0.0713447,-0.0024172026,0.0073687797,0.034918312,-0.14517581,-0.038289405,-0.049639132,-0.079432,0.01182319,-0.04081536,0.0046370635,-0.006740253,0.039251678,0.014223299,-0.025791707,-0.0025008833,-0.12271502,-0.10493052,0.07918903,-0.056569245,-0.027605595,-0.026419187,-0.11548701,0.036988158,0.0070358645,-0.0019385006,-0.0015638088,-0.033497013,0.014387418,-0.004804733,0.09825068,-0.03303816,-0.08005072,0.00896869,-0.003380333,0.012600005,0.01091528,0.00061891525,0.07256044,0.014890151,0.019910283,0.04803014,-0.0018366656,-0.072628394,0.05801495,0.0017476741,0.025401078,-0.036421284,-0.009640339,-0.005335447,-0.008649466,0.0011192786,0.042587034,-0.073609665,0.043418426,0.010333355,-4.1924116e-33,-0.018140914,-0.10338574,-0.053529218,-0.0021116652,0.03323152,-0.099231124,-0.04800934,-0.032195184,0.0121535435,0.012875464,-0.02171244,-0.050950784,-0.018352695,0.046635747,0.03294731,-0.07643085,-0.016109802,0.05186763,-0.011723614,-0.029890265,-0.038923066,-0.0077710017,-0.03229052,0.046085924,-0.0039013484,-0.03305328,0.003630709,0.039057028,-0.03279604,-0.031477585,0.0042190636,0.073833115,-0.060477316,0.029923104,0.031817365,0.10985641,-0.0111544635,-0.036637533,0.022073483,-0.034325782,-0.03649594,0.072923504,-0.021629151,-0.0003610076,-0.012129409,-0.022640003,-0.07299598,0.061992824,-0.050154574,0.06093187,0.08359897,-0.035552755,0.04132007,0.015560599,-0.048615847,0.097721145,0.019890916,-0.02843996,-0.046040986,0.050648585,-0.006311801,0.059185494,-0.058291048,0.03472807,-0.0067543443,0.04013107,-0.077636294,-0.07139473,-0.03231943,-0.053465616,-0.02809681,0.04489998,0.037636593,-0.06618639,-0.0023360434,-0.027248329,-0.04663211,-0.067893445,0.05368978,-0.008563231,-0.051083103,-0.083127715,0.031338777,-0.031025037,-0.003650063,-0.042451534,-0.0006708441,-0.10295716,0.006288352,0.036575604,-0.012017347,-0.048829578,-0.005357973,0.03094786,0.06806441,4.8888094e-34,0.07389289,-0.101775266,0.08041809,0.055605303,0.018571025,0.054421358,-0.021945242,0.065647595,-0.049034704,-0.045249205,0.015731204,0.016503634,-0.07764674,0.0112669775,0.0487311,0.033336814,0.094121516,0.109816805,0.0027994271,-0.029955303,0.0259706,0.09442582,0.031500816,0.09622725,-0.022423225,0.009699506,-0.009862336,-0.0114690745,-0.041478466,-0.022535415,0.019752366,0.02001687,-0.07982622,-0.05701133,-0.031880144,0.09467996,-0.0460491,0.006629589,-0.10599835,-0.09668719,0.060382932,0.021794938,0.0069155814,-0.0055950494,0.03715389,0.044634763,-0.032902624,-0.03303124,-0.025624678,0.025245886,0.044727165,0.0017625041,-0.02561447,0.04934291,0.028009128,0.005960894,0.011635838,-0.102959074,-0.052989166,-0.0138235185,-0.056413997,0.0809664,-0.004225364,0.00876985,0.062478233,-0.058371305,-0.05756953,0.024423374,0.09463915,-0.050143447,0.12781672,0.024040239,-0.043187782,0.050344616,-0.09534968,-0.08628331,-0.073307276,-0.08387953,-0.028172405,-0.034952004,-0.045697976,0.04896673,-0.013342844,-0.015219591,-0.11664749,-0.03369616,0.058768593,-0.0232465,0.007842363,0.042067237,0.063870564,0.045287337,-0.000704977,-0.018083947,-0.007247117,-2.0480522e-08,0.02452104,-1.8721044e-05,0.05059593,0.05602323,-0.034446266,0.057289395,0.053109825,0.07080501,0.0030971845,-0.032059953,0.015577789,0.09584429,0.09013162,0.01832104,0.06069295,-0.009981482,-0.092403196,-0.03017604,-0.026130537,-0.020732619,-0.097302295,-0.0069381846,-0.00010685391,0.077048704,-0.08803964,-0.031495374,0.034345564,0.11038711,-0.00023270898,-0.049948055,0.0057952376,0.07853815,-0.09727595,0.047454525,-0.031444367,-0.019495912,0.055433474,-0.00961367,-0.015272047,0.05079954,-0.07358757,-0.03621486,-0.058032952,-4.525015e-05,-0.0026089516,-0.03502708,-0.018324014,0.015237718,0.016494395,0.034955025,0.115678385,0.08982949,-0.003124079,0.023015939,-0.031122474,0.030385366,-0.034841515,-0.010674027,0.00077300944,-0.065016754,0.08057821,-0.014683072,0.13249041,0.02296687 +1.1.1.75,Requires K+.,384,0.99999994,-0.011973202,0.043285,-0.0042351712,-0.014561461,-0.06611634,0.01375039,0.04314299,-0.086106256,-0.04198558,0.058892824,0.0015147821,-0.052170478,-0.009049526,0.038078316,-0.0017842386,-0.026045151,0.03373842,0.069880135,-0.0391223,-0.020913837,-0.014112076,-0.12790214,0.022661725,-0.034373,0.035906564,0.015405885,-0.0018822956,0.012303849,0.097200036,-0.022729209,-0.07337843,0.037360594,0.081528656,-0.0540824,-0.06448939,0.036211677,-0.033948336,-0.020929571,-0.07941732,0.009037451,-0.028186796,-0.07120455,0.0052978043,0.029871425,0.024133643,-0.00922318,0.0054672253,-0.029752733,0.026895689,-0.035085198,-0.046411466,0.011655643,-0.053169016,0.07919036,0.0084723625,-0.0002752737,-0.070283554,-0.015885089,0.042236414,0.025412327,-0.062028263,-0.011484679,-0.008255675,0.073726535,0.080538064,-0.01831351,0.007153286,0.015338426,-0.016431611,0.079194985,0.004872894,-0.02152527,0.0036603198,0.025499474,0.017710896,0.02258193,-0.040787525,-0.028839597,0.084676206,-0.06307915,-0.031836547,-0.0070996108,-0.09693092,0.042882793,0.046219844,0.0045346045,-0.027628945,-0.062102217,-0.058200195,-0.0071597127,0.0696403,-0.061322615,0.0018403294,-0.023056937,0.034079805,-0.0033014452,-0.034966886,0.041743107,-0.1365935,0.1135545,-0.08156919,0.023065744,-0.002341358,0.08219856,-0.03004527,-0.08523026,0.01277058,-0.044055298,-0.017520547,0.036275,0.029593939,-0.001509716,0.0059742453,-0.04058601,0.039190575,0.03442485,0.035342243,-0.063974075,0.03799893,0.009260407,0.07566149,-0.056892477,-0.07642264,0.035530236,-0.04176967,-0.051338974,0.07730515,-4.6961973e-33,0.045318317,0.06119016,0.05842884,-0.026671184,0.012379429,-0.045573838,-0.078400046,-0.014812848,-0.07711402,-0.10753487,-0.08342619,-0.013644277,0.019335963,-0.031132665,0.0856221,0.015746173,0.042634815,0.039101336,0.02551937,0.006753579,0.10622225,-0.06878337,-0.04743217,0.05285335,-0.033808146,0.06949504,0.045851525,-0.04755881,0.03368239,0.049188416,0.014741106,-0.028717095,-0.05718963,0.05500229,-0.06811456,0.052188326,-0.06425293,-0.035434257,0.028992537,0.010072699,-0.08376979,0.0063968557,-0.0831305,0.0417631,0.019770876,0.033384036,0.1096493,0.040912293,0.0054131383,0.04745185,-0.0320691,-0.015536821,-0.04105941,0.030531969,-0.0049737063,0.10646495,0.08019807,0.0057268324,0.020438207,0.045080304,0.0038633258,0.0048317504,0.0018798964,0.11818123,-0.062252887,-0.056868326,-0.06942979,0.03121487,-0.012150378,0.007591262,-0.11403935,0.041989677,0.015859079,0.006607477,0.05741601,-0.017066104,0.0071510156,-0.014410341,-0.034112856,0.026150437,-0.09260408,-0.04550033,0.0037257657,0.011634387,0.032545727,-0.056253582,0.025173651,-0.0070249983,0.049980953,-0.03109965,-0.073664755,-0.03607869,0.011686728,0.035647836,-0.084594026,3.641663e-33,-0.010556966,-0.02194536,0.014496729,0.07466648,0.05128772,0.099546336,0.0127763925,-0.0921169,-0.005293356,0.041596577,0.025468362,0.037166853,0.06823506,0.021932432,0.10843402,-0.009987714,-0.08346317,0.066374205,0.012538732,-0.0065150475,0.016493395,0.019045953,-0.018430017,0.04555583,0.018380012,0.088210106,-0.10184116,0.08433503,-0.07150146,0.021779718,0.03709466,-0.016703593,-0.16276854,-0.020252246,-0.027683157,-0.0478467,0.00030881434,0.05604177,-0.070508085,0.03619039,0.07768172,0.022464514,0.011464897,0.13347082,0.000817564,-0.025166744,0.14740452,-0.035579443,0.07342357,-0.07544951,0.04035523,-0.004452163,-0.07226668,0.00091637747,-0.055442717,0.030052764,-0.038504895,0.13256218,0.008572771,-0.025968486,-0.031813417,-0.0831427,0.06753835,-0.02797019,0.014271223,-0.07633369,0.05268393,0.06516914,-0.00029806935,-0.021654116,-0.0026098292,0.09572864,0.0785794,-0.044070214,-0.061417814,-0.009646647,-0.07534077,0.08262802,0.053935427,-0.034156457,-0.05214512,-0.01003537,-0.024082722,-0.00048191982,0.08417026,-0.014548971,0.05889159,-0.0094088875,0.010234952,-0.0006864294,0.001696181,0.039384525,-0.045780417,0.05080298,-0.022749437,-1.6420127e-08,-0.015248074,-0.051869184,-0.06886554,-0.054156534,0.112731315,0.051722016,0.014215512,-0.025495453,-0.014752663,-0.022282196,0.11081345,0.019077834,0.042247012,0.066605866,0.0029454415,-0.07681374,-0.0017012905,0.058234047,-0.10625991,-0.022169802,0.0027118872,-0.012420434,0.018671364,0.10441667,-0.033060312,0.022632334,0.050272673,0.016927458,0.027302861,0.03619268,0.016335199,0.021316633,-0.025173249,0.017281817,0.0008164402,0.10752068,-0.01941244,0.045688797,-0.016760834,-0.006094522,-0.027594144,0.014397665,0.0011091592,-0.018717874,-0.020964688,0.005054593,-0.035621,-0.08123605,-0.065157324,-0.054495126,0.028132757,-0.016319273,-0.018637652,-0.0057615032,0.065747656,0.022008596,-0.005068056,-0.0672446,-0.0091039445,-0.024905914,0.07190794,-0.07309224,0.048534967,0.0321892 +1.1.1.76,"This enzyme catalyses the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol. It can also catalyse the irreversible reduction of diacetyl to (S)-acetoin.",384,0.99999994,-0.058242414,0.05192818,-0.1123324,0.039879907,0.124970704,0.0047540953,-0.058058873,-0.04951259,0.040101666,-0.008465627,-0.030306373,0.017086118,-0.090813056,-0.0041406974,-0.045247886,-0.017925808,-0.0061617075,0.09395819,-0.007822892,-0.052350663,0.09514199,-0.041299175,-0.03718219,-0.0005795895,0.046971407,0.058871657,0.021798356,0.030432591,-0.01782509,-0.14336851,-0.002086605,-0.065642096,-0.022827543,-0.058595125,9.529615e-05,0.027579581,-0.04680603,0.02919612,0.009567988,0.044000104,-0.031393167,0.018113172,-0.06429446,-0.055815335,-0.037491664,-0.067658894,-0.10659638,0.059931174,0.046699,-0.06970471,0.04010255,0.02425656,-0.07137965,0.005846071,-0.0039249333,0.03599853,-0.07016498,0.0006208549,-0.03627877,-0.006319573,0.06361951,0.036346566,-0.053585984,0.03440808,-0.002380434,-0.014416849,0.052393798,-0.09525286,0.019429624,-0.022261087,-0.041603502,-0.090734795,-0.048051823,0.03913652,0.093988724,-0.005290925,-0.020808939,0.04943925,0.08384561,-0.022440584,0.11283948,0.02277895,0.026707541,0.067242585,0.06663271,0.023808142,-0.08704427,-0.08624464,0.087462634,-0.013279643,-0.0080870725,-0.03965761,-0.005794109,-0.028914498,-0.011086207,0.017372876,0.04405869,0.016893592,0.023643015,0.046227273,0.021105297,0.10587287,-0.038896047,-0.15838197,-0.063476875,0.03406445,-0.00035318037,0.07113134,0.020903734,-0.034584247,-0.029874146,-0.028398933,0.053228483,0.039110776,-0.0076943575,0.04631401,0.038368758,-0.046846207,-0.00523684,-0.0089046685,0.06472584,0.028476434,-0.0013701072,0.05201495,-0.010289688,0.0471176,0.0010973406,1.4213454e-33,-0.0065366216,0.09855931,-0.018791493,-0.00804326,0.049254756,-0.0133861555,-0.060616504,0.033114027,0.0025083916,0.017596489,-0.029614279,-0.051996395,-0.0029080817,-0.0067454786,-0.006451534,-0.065425985,0.06164911,0.011644403,0.01972542,-0.040285666,-0.036820628,0.08860839,-0.066396624,-0.012378354,0.0625497,0.04784784,-0.0069971303,0.022018056,0.067716315,-0.0064251795,0.039337438,-0.03512805,-0.07668238,0.0044598263,-0.04877867,0.021186236,-0.010550769,-0.05108851,-0.0079452535,0.06466928,0.024971021,0.00218137,-0.08177264,-0.055513892,-0.023331827,-0.053152513,0.0038391,0.08087668,-0.015503808,-0.004074984,0.018716773,-0.01629414,0.068373285,-0.041150067,-0.06252924,0.016080936,-0.022562606,-0.019510323,0.067210026,0.0248127,-0.010297196,-0.013754471,-0.00086659804,0.03388049,-0.03316115,-0.052307997,-0.032455076,0.01667066,-0.007109764,0.020405386,-0.11182926,0.038331125,0.07837795,-0.01528243,0.055496063,-0.046858013,0.0014821964,0.040453676,0.1025239,-0.02500161,-0.0642005,0.010946189,0.035019483,-0.0038334907,0.00079503795,-0.028588453,-0.043745164,-0.121180035,-0.023415456,0.034180827,-0.009234149,-0.030657081,-0.0070848637,0.06463107,0.106890656,-3.2560073e-33,0.028149424,-0.08635944,-0.014283998,-0.057690866,-0.05839569,0.06551887,0.03546234,-0.032008313,-0.015343432,-0.04019548,0.04384522,-0.06457156,0.054565877,-0.08336341,0.0006318009,0.027176423,-0.00056702504,0.049838886,-0.0144500965,0.047219604,-0.030688388,0.07809651,0.047194056,0.02490519,0.02536771,0.020947304,-0.022749672,0.017443577,0.12588923,0.107204534,0.06673528,-0.04318589,-0.004823197,-0.029029662,-0.07859787,0.0881358,-0.03398218,0.0617949,-0.062731825,-0.0012621504,-0.009657311,-0.011460217,-0.046714928,0.01605893,0.087296955,0.090902254,-0.020134376,0.0015044896,0.056884103,-0.11501018,0.027413331,-0.001982233,-0.050631683,0.08522383,0.022309346,0.07083988,0.082280315,-0.058608115,0.0034611216,-0.0060288096,-0.10748276,-0.031604342,0.019750554,0.044925854,0.08179318,0.04757034,-0.031689662,0.052866705,0.06291613,-0.08745543,0.052063465,-0.008371868,-0.004626127,0.05781913,0.03600333,-0.06972072,-0.02930627,-0.029755786,-0.04747876,-0.06790611,-0.019368881,-0.06881512,-0.062273905,-0.10968209,-0.11392308,-0.12518518,-0.0025852253,0.09212892,-0.018562973,0.06986556,0.014759301,-0.026851973,-0.028536983,0.050967608,0.098005466,-3.3175333e-08,0.049510956,-0.053322025,0.046803433,-0.026711302,-0.07504854,0.01797124,0.084704205,0.042450856,-0.007568738,-0.08358974,-0.033594467,0.0463657,0.07625778,0.0255105,0.05521084,0.048126664,0.014082964,0.05362912,0.017321529,-0.05640832,-0.0016011418,-0.04764007,-0.04154635,-0.02158884,0.043720543,-0.058481555,0.0031737986,0.043204308,-0.0052744425,-0.007427056,-0.01213475,0.06310715,0.0069911997,0.024880877,-0.021285374,-0.018607728,-0.00046715763,-0.017013354,0.033071805,-0.0033856696,-0.042106997,0.015181321,-0.11739084,0.02707628,-0.0375879,-0.050947428,0.03627538,0.045660768,-0.025010584,0.011864466,0.034818962,-0.055408962,0.007033378,-0.09031234,-0.018654676,0.0027844105,-0.0023139908,-0.022603981,-0.006201153,-0.046302833,0.03949835,0.016868861,0.13710152,-0.020265095 +1.1.1.78,"This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH), by its cosubstrate requirement, reaction direction, and enantiomeric preference.",384,1.0,-0.012698727,-0.043459482,-0.083260104,-0.058354508,-0.014338339,0.014163511,-0.092599556,0.05974105,0.03322854,-0.013320485,0.0011396017,-0.04726574,-0.1077904,0.010741412,-0.0041824956,-0.027852515,-0.017450992,-0.07656895,0.04527753,-0.01721709,0.060647562,-0.010228795,0.03531819,0.010843633,0.05263467,-0.04216906,0.03305873,0.014340294,-0.053611483,-0.15296245,-0.03880128,-0.025236035,0.015866175,-0.022836162,0.008423914,0.066565886,-0.06377809,-0.029331231,0.007139254,0.037418403,-0.0005999959,0.0008641361,-0.0816404,-0.0015513814,-0.055402882,0.010955594,-0.026644617,0.023088114,0.03217652,0.048186168,-0.040215615,-0.044727493,-0.03852309,-0.0013927668,0.03061964,0.017458053,-0.015951032,-0.006369261,-0.010453156,-0.010423561,0.013002272,-0.049172316,-0.013047943,0.017706413,0.036656767,-0.06437305,0.08725836,-0.10929525,-0.023550631,-0.095284894,-0.06449112,-0.043462504,-0.029122971,0.06905715,-0.032758858,0.037984025,0.0323182,-0.03527248,0.024640813,0.017111322,0.030507915,0.043329187,-0.010462905,-0.00056364003,0.12046652,-0.006053972,0.020794632,0.026189398,0.023342438,0.015309318,0.02120655,0.016761051,-0.019161437,0.009426773,-0.05773054,0.06035394,0.0024629773,0.13430098,0.05464907,-0.049757063,0.05713775,0.067706734,0.010690634,-0.030553352,-0.00075313845,0.06167209,0.013446021,0.09890183,0.042966038,0.00975822,-0.029038256,-0.04008758,0.038225044,0.01386887,0.010660083,0.06914911,0.0018093234,-0.03858574,-0.06831502,-0.01743835,0.027446248,0.012029732,0.078195274,-0.006697577,-0.021021912,0.010125541,-0.113258265,-2.9511137e-34,0.08637625,0.026741704,-0.039425045,-0.031264488,0.013764851,0.07300545,-0.049115106,0.05302292,-0.049047425,-0.045674194,-0.040257744,0.018963426,0.0070618773,0.033752806,-0.0065139458,-0.0012903692,0.008763763,-0.034259673,-0.01575324,-0.007096483,0.026877997,0.044346157,-0.048433933,0.006157333,0.011657639,-0.04861687,-0.080067016,0.069866985,-0.030190894,-0.019247584,0.0074076755,-0.13123274,-0.05054438,0.03239936,0.0366644,-0.06512427,0.0004994998,-0.042600602,0.015046599,0.01902657,0.016765937,0.040097743,0.035505142,-0.062627904,0.07112774,-0.029302372,-0.04736758,0.045232493,0.04391016,0.056181293,-0.0015424088,0.01518643,0.13329995,-0.021194635,0.018954352,0.035071168,-0.013395676,0.04312562,-0.011836801,0.057606168,-0.031124188,0.10700593,0.03311255,0.05963191,-9.256692e-05,0.015020103,-0.11351245,-0.05078159,-0.038491193,0.1021395,-0.028017655,0.014301777,0.023096196,-0.02748607,0.01440505,-0.08621949,-0.033977304,-0.023872837,-0.0026989295,-0.012091405,-0.051072028,0.017544525,-0.088545546,-0.014345904,-0.08242572,0.029132254,0.06421926,-0.0388645,0.035348132,0.014675689,0.08990055,-0.058427706,-0.021904713,-0.039915852,0.09345855,-1.7886133e-33,0.06768946,-0.045821793,0.096634224,-0.08643162,-0.04643574,0.142516,0.121463604,-0.05079094,5.636251e-05,-0.03850882,0.043727018,0.0061393175,0.0061619985,-0.056563538,0.07226819,0.0009972148,-0.05625924,0.054168988,0.027129216,-0.022811238,-0.006478426,0.13136575,-0.06527697,0.050175183,0.096453585,-0.01851583,-0.061916284,0.06762619,0.06038196,-0.07015525,-0.095087536,0.030424917,-0.025193775,-0.047097143,0.017805472,0.04737751,-0.12131494,-0.01267317,-0.012666782,0.09179207,-0.035229895,0.06608855,-0.043033496,0.023244949,0.02299205,0.0858431,-0.0898702,-0.016867427,0.026989711,-0.05102051,0.030153796,0.020356148,-0.010014849,-0.0008825544,0.033968277,0.0028109495,0.00033166117,0.043145463,-0.0018296359,-0.0039156876,0.010810514,-0.023645004,0.01653268,0.0019752737,-0.0027559802,0.0045943377,-0.045404844,-0.03564622,0.037256073,0.018468885,0.049893055,-0.02534954,0.012448838,0.05133275,-0.025840987,-0.075616986,-0.06426044,-0.022889586,-0.03546567,-0.0510688,0.05092761,0.025328474,0.012779414,-0.023696095,-0.03406596,0.022538967,-0.004763688,0.039835177,-0.018218279,0.06576071,-0.02358317,-0.03468844,-0.0848322,0.06023775,0.03546252,-3.8041353e-08,0.047129028,-0.02349024,0.077442795,-0.04316098,0.019948626,0.07009477,0.04343413,-0.0671907,0.03452043,0.017786,-0.04414234,0.1318157,0.05245451,0.06661221,0.037970107,-0.0040159035,-0.05369562,0.013489232,0.03397125,0.059184626,-0.04260832,0.00011737269,-0.17392798,0.07726215,-0.020969138,-0.022967583,-0.016618958,0.0690035,-0.00052637176,-0.0551929,0.029431889,0.03401023,0.112761684,-0.042159252,-0.05567657,0.03145458,-0.060335573,0.024588037,-0.076915935,0.020851461,0.042213954,-0.0955958,-0.0446113,0.01019509,-0.049285967,-0.046453077,0.06780604,-0.037069682,0.014455147,-0.01902515,-0.013140663,0.0034884373,-0.05008267,-0.07264209,-0.020272493,0.0049009165,-0.08865261,-0.06419757,0.010167671,-0.06104613,0.08030535,-0.0017637888,0.15386982,-0.079375 +1.1.1.79,Also reduces hydroxypyruvate to glycerate; has some affinity for NAD+.,384,0.99999994,-0.023124043,-0.01571289,-0.029282637,0.053940844,-0.0032245843,0.02889956,-0.06258701,0.045435935,0.00410065,0.005820783,-0.025522524,0.05789175,-0.03634722,0.042683735,-0.011396586,0.015680613,0.024038706,0.035462424,0.031966344,-0.030502968,0.071004346,0.01127822,0.06284439,0.0128965555,0.06351616,-0.022178574,0.0048739198,-0.014115613,0.052889917,-0.02224709,-0.037911966,0.049654376,-0.010708554,-0.03141257,-0.043946378,0.110133275,-0.05203256,0.009913036,-0.02202053,-0.043246813,0.031738687,-0.019800799,-0.032213964,0.031968422,-0.028864335,-0.047081374,0.027246878,0.020381344,0.029004764,0.05176605,-0.06481829,-0.053715598,-0.056879845,0.005253199,0.043628406,0.018381855,-0.06872741,0.04781109,-0.01730507,-0.03258997,-0.036995545,-0.056095954,-0.018496504,0.018268334,0.052994467,-0.05365097,0.080566406,0.004007356,-0.042354986,-0.03172584,-0.06603651,0.002883344,0.087960996,0.047054566,-0.040052116,0.045810632,-0.11211606,-0.05786002,0.050412092,0.027626742,0.050026927,0.07757388,-0.03445165,0.13755703,0.03841182,-0.009766527,-0.005487699,-0.06031369,-0.09075281,-0.029985003,0.022810092,0.004485552,-0.041848257,0.06758303,-0.1384961,-0.035869386,0.04747979,-0.0035625114,-0.048378218,-0.049410973,-0.018458465,0.10187798,-0.009725025,-0.014651755,-0.088485755,0.034666628,0.0039106896,0.07999537,-0.038587723,0.014470849,-0.007412238,0.042404518,0.006564325,-0.024099616,-0.07657532,0.11304507,0.013017129,0.009796736,-0.084536,-0.04039087,-0.016325068,-0.041442662,0.020713547,-0.011756869,-0.055256274,0.021618802,-0.04459729,1.5156572e-33,0.06754637,0.013460953,-0.006193513,-0.013441569,0.049847588,0.031259328,-0.09376213,-0.007934543,0.021806322,-0.034064524,-0.01805581,-0.082813114,0.090844564,0.0521195,-0.03056655,-0.025081264,-0.08022967,-0.040065832,0.060008008,-0.029908618,0.04012508,0.032890692,0.025836078,0.00046441608,-0.013395202,-0.0024750563,-0.0005137842,0.056137633,-0.0021318374,-0.005445922,0.022260724,-0.07601172,-0.06579432,0.00506571,0.029309457,0.07041266,-0.048866056,-0.12480569,0.021460768,0.06393568,-0.0775127,0.023275789,-0.011184861,-0.073031686,0.04877101,-0.09829686,-0.010027667,0.061590776,-0.03986521,0.071442865,0.11432104,-0.04844171,0.071766876,-0.0149300955,-0.030496549,0.025400447,-0.009352886,-0.03780726,-0.041502457,0.091569625,0.0050930316,0.013194353,0.018755166,0.025749857,-0.07253834,0.017712617,-0.12572199,-0.08885318,-0.041425075,0.06483111,-0.013158045,0.019985033,0.0977503,0.045162994,-0.01847455,-0.06801895,0.011325507,0.020778794,0.028683215,-0.020201346,0.01486286,-0.03760334,0.010158113,0.049942207,-0.028780457,0.043004774,0.039732225,-0.07996223,0.025981303,0.0021523484,0.03294537,-0.06660795,-0.008541026,-0.029077949,-0.029825183,-2.7902838e-33,0.076565504,-0.09875743,0.008875785,-0.06115225,0.008110704,0.034197263,0.03373902,-0.0628787,-0.03885165,-0.094354905,0.05817566,0.06955902,-0.048593573,0.0038434945,0.03276806,0.0023903085,0.0012591099,-0.022686701,-0.056354817,-0.025455406,0.037530396,0.15070297,0.023913277,-0.03837246,0.070879616,-0.02914262,-0.048757583,0.01060957,0.008112397,0.117188506,0.01015056,0.00033111512,-0.1501468,-0.08061767,0.039561756,0.054204434,-0.08290421,-0.021552848,-0.05049102,-0.0065860418,-0.008953416,0.008906929,0.060202092,0.04017873,0.09404946,0.06483367,-0.03239439,-0.014699278,0.002943929,-0.0040340554,0.0519009,0.016401362,-0.034809835,0.074037425,0.08071965,-0.016327452,0.018418582,-0.06290874,0.031286687,-0.008107988,-0.072097145,-0.020086749,0.004161769,-0.06383548,0.10570592,0.028040536,-0.002864119,-0.0072790547,0.064103924,0.02730021,0.09475815,0.0060176584,-0.016640866,0.04846081,-0.024532147,0.047644634,-0.060166616,-0.001286047,-0.08798713,0.00028442946,-0.026318885,0.028206673,-0.032954313,-0.09398384,0.0073751505,0.023706678,-0.0548767,0.0942424,-0.032842398,0.061074972,-0.02747045,-0.04627822,-0.03782651,-0.05169969,0.018505253,-2.2953918e-08,0.005551775,-0.0544129,0.0010691688,-0.054534923,-0.048683353,-0.002617973,0.038198285,0.042999797,0.022236768,-0.030275986,0.03328529,0.10107368,0.08224454,0.06484398,0.00080386933,-0.0082653975,-0.010987264,0.054677714,-0.06660843,-0.053238336,-0.14073032,-0.043981947,-0.07098538,0.09711861,0.009477024,-0.07593148,0.046521157,-0.008215657,0.07587216,-0.0812923,0.051457502,0.028349288,0.096783765,-0.017431619,-0.0040029306,0.09435168,0.05160225,0.07359195,-0.005471354,0.04027383,-0.045498554,-0.087111115,-0.013071102,0.053206168,0.054547805,-0.0072526955,0.033883877,0.039678685,-0.039110973,0.008308608,0.040057026,-0.012778949,-0.01162881,-0.0648925,-0.06417827,-0.013240422,-0.041608248,-0.009294856,0.05329074,-0.05536798,0.0005646056,-0.00591416,0.10565583,-0.030579612 +1.1.1.80,"Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols.",384,1.0,0.018756239,-0.06883968,-0.0036021401,0.05508007,0.058287706,0.028705416,-0.06935291,0.018977214,0.06336967,-0.06631064,0.07650475,0.079220496,-0.08565451,0.11098069,-0.004146011,0.03206997,-0.033080786,0.020956185,0.030462906,-0.014434146,0.033464942,-0.054351643,0.03795687,-0.027891593,-0.038968377,0.02909396,0.00740007,0.03908271,0.054130834,-0.082423,-0.03177382,0.07615554,0.0010150871,-0.026685044,-0.020655764,0.0016643992,-0.003585106,0.03916843,0.081119634,-0.024716057,0.10389015,-0.040310454,0.012900143,0.016791036,-0.050339032,0.010553491,-0.06513946,0.023468116,-0.0083168475,-0.0071655577,0.002826313,-0.036566827,0.029788492,0.08716204,0.096773185,0.020295098,-0.095850736,0.001721809,0.035011362,0.055181317,0.0023784775,0.014938711,-0.054205257,0.08490816,0.060464177,0.0018659867,0.03958216,0.042009935,-0.06117912,0.012875283,-0.0015874215,-0.077173285,0.04893447,0.059634328,0.047583517,-0.08158974,-0.03730868,-0.003581343,-0.055383384,-0.027292265,-0.09612803,0.022322658,0.009695885,0.03615985,0.0008436288,-0.051382698,-0.053182893,-0.119333066,-0.119295225,0.08093269,-0.008090512,-0.05281227,0.022227824,-0.09114566,0.04868914,0.014498448,0.021914944,-0.012377586,-0.02098349,-0.03478783,-0.01813148,0.03589469,-0.028825609,-0.059430275,0.0012228027,-0.017109966,-0.013258604,-0.0034172807,0.034491006,0.026826888,-0.010373998,0.048372764,0.082211375,0.0034611812,-0.05907727,0.10926297,0.041828047,0.0265287,-0.015662203,-0.04197211,-0.02616222,-0.012145827,0.017488405,0.017339343,-0.03070166,0.06772529,0.0037158479,-3.8781366e-33,0.012351381,-0.11093121,-0.030998798,-0.01740952,0.021409458,-0.08038893,-0.052079007,-0.051334146,-0.014611029,-0.012579729,-0.021994049,-0.040979795,-0.017401822,0.064542554,-0.0054896898,-0.06613336,0.069340914,0.025345758,0.024687288,-0.046529096,-0.050239135,0.032657523,-0.02306808,-0.01458062,-0.0009368484,0.02714866,0.036691587,-0.013208538,-0.012475608,0.0028659934,-0.012855399,0.0779977,-0.04423789,0.047968533,-0.012350861,0.11858387,0.021962896,-0.0245431,-0.01426926,0.00658008,0.020298073,0.039974745,-0.030480968,-0.0056686304,-0.022825675,-0.04139616,-0.10463054,0.059867337,0.017414063,0.069634564,0.06640028,-0.040076517,0.008578707,0.004729764,-0.039209276,0.06654873,-0.026638549,-0.06504658,-0.018276544,0.041683342,-0.04575752,0.030047778,-0.088862844,0.036485102,-0.02813351,0.054268166,-0.06619358,-0.09785852,-0.04564824,-0.01942549,-0.057024673,0.049560525,0.06739477,-0.02426672,0.033681214,-0.0025003531,-0.03997454,-0.04714978,0.05963445,0.03689991,-0.08445633,-0.070580326,0.025502605,-0.012581686,-0.01815036,-0.048526026,-0.0167144,-0.12648596,-0.0049207583,0.017928999,-0.013642317,-0.033712782,-0.015151323,0.057663757,0.07219887,2.7248756e-34,0.009065857,-0.111033805,0.092115976,-0.01602654,0.008089812,0.031358708,0.019178657,-0.018356698,-0.04849685,-0.003150453,0.064571604,0.0077216276,-0.110353254,0.018572642,0.02314511,0.050266005,0.031057563,0.104993686,0.0150076365,-0.016176242,0.038262505,0.10329513,0.03557704,0.06245917,0.009519108,0.029912144,-0.051164962,0.018053612,-0.06460426,0.024298126,0.024253087,-0.010125492,-0.07599012,-0.06455586,-0.03667008,0.044863135,-0.07995976,-0.040607408,-0.1198234,-0.09742141,0.08279326,-0.010491036,0.024144698,-0.024194036,0.019358713,0.028792128,0.007635367,-0.039858878,-0.069400206,-0.00256267,0.025745446,0.01927157,-0.036049888,0.10585615,0.028941128,0.052717112,0.018554576,-0.046083223,-0.029867928,-0.006310531,-0.049343746,0.060816094,-0.03434868,-0.04885759,0.084318556,-0.08430868,-0.040403023,0.033006113,0.06647329,-0.022848258,0.1064199,0.03588041,0.010214101,0.04435162,-0.1100333,-0.08634749,-0.067037426,-0.103033625,-0.02210008,-0.026580838,-0.0585276,0.0024248029,-0.019182991,0.017147362,-0.07441895,-0.07700653,0.06420325,0.0020979606,0.019795517,0.097432755,0.006210399,0.030034432,-0.013865435,0.021095239,-0.017560616,-2.0714511e-08,-0.004673728,-0.03445913,0.054615214,0.060732476,-0.015794681,0.009916468,0.057286296,0.06251389,-0.03761022,-0.07441643,-0.024289565,0.112988934,0.098053694,-0.0042234226,0.06731227,-0.027845275,-0.019725649,-0.030372616,-0.031782735,-0.046643056,-0.07778033,-0.0069402787,0.009308821,0.07688891,-0.10750063,-0.042363893,0.059144616,0.073871225,0.03636174,-0.06208642,0.0033554235,0.06007028,-0.05688749,0.013382277,-0.01606198,0.03850141,0.03220528,-0.035698123,-0.017019568,0.06632367,-0.054456808,-0.09269782,-0.07641954,0.036467794,-0.037507504,-0.024099763,-0.033916045,0.009426399,0.0052960836,0.034792356,0.10551829,0.029456813,0.02667928,-0.004140786,-0.039118126,0.05341475,-0.013505952,-0.011191477,0.030164797,-0.058558356,0.059267092,0.034337997,0.17095059,0.043239426 +1.1.1.82,Activated by light.,384,1.0,-0.019373883,-0.03107095,-0.028937045,0.12106886,0.005601697,-0.017950919,0.19210353,0.0062056175,0.07511086,0.0522648,0.14486425,0.014051186,-0.032504752,-0.0073330035,0.017493613,0.10050609,0.010569039,-0.03384271,-0.07579198,-0.066749685,0.08708582,-0.047227774,-0.0387897,-0.021646125,-0.03726203,0.06109927,-0.052459456,-0.045989703,0.024306882,-0.014192356,-0.0021828313,0.027347535,-0.028015964,0.00906013,-0.10401932,0.009317097,-0.0025010828,-0.033825178,0.03194124,-0.0075676967,0.013950009,-0.18585588,-0.02871575,-0.01833036,-0.044510152,0.06342652,0.036367152,0.06941694,0.009062702,-0.050551012,0.0106336,-0.05532989,-0.018838707,0.045757785,0.0022764488,0.012170019,-0.016802005,0.032050077,0.055040807,-0.056945626,0.023365477,0.024188517,-0.042112954,0.04648848,0.03961252,-0.025650917,-0.032512486,-0.05463582,0.09271499,-0.04757769,0.06792501,0.004827793,0.03132816,-0.04583379,0.021114249,-0.10570593,0.025370764,-0.025989925,0.03885834,0.076256014,0.018929819,-0.00031201367,0.007401908,0.11889954,0.113940805,0.056352563,0.049001038,0.0036518483,-0.086932145,0.049451407,-0.0459338,-0.024707554,-0.043821614,0.0015473609,-0.059593394,-0.0556808,0.0063900705,-0.06376034,-0.07096234,0.057847336,0.02551588,0.026011981,-0.069608256,-0.023002949,-0.038190722,-0.09763059,-0.016618153,0.051473346,-0.0024051613,0.00337132,-0.002617176,-0.038306344,-0.03033142,0.0012140955,-0.04610765,0.05751172,-0.00310525,0.0273964,-0.0014932117,-0.009287502,0.0424434,0.0218544,-3.2529337e-05,-0.0065509407,-0.017766101,-0.035016757,0.01919157,-5.5244976e-33,0.04811437,-0.01729955,-0.01966831,-0.026793012,-0.0060899425,-0.039785072,0.021898838,-0.014858789,-0.030413222,-0.022112705,0.0318451,-0.0014511225,0.0063965954,0.07700558,0.064255394,-0.09442745,0.027835388,-0.0067321826,0.040740907,-0.046746407,0.0007507554,0.10259794,0.015195164,0.016043888,-0.03195775,0.060027257,-0.05657454,-0.0474641,-0.014397967,0.022939708,0.036183294,0.09250596,-0.039373852,0.04979706,0.01278896,0.10937961,-0.023933351,-0.07812326,-0.01322494,-0.017261306,-0.021822007,-0.01102411,-0.03294144,-6.704365e-05,0.04345684,0.017954001,-0.06529257,0.04180501,0.013899367,0.030002616,0.08993973,-0.093575954,-0.0074910666,-0.022490546,0.024592424,0.054840412,-0.032362323,-0.028564092,-0.028071243,-0.038011663,0.014529435,-0.0074564624,0.02041176,0.06340685,0.049321912,-0.028379755,-0.002381783,0.0046374914,-0.01811736,-0.03041285,-0.076870166,0.010292893,0.027608972,-0.02009846,-0.04067225,0.017725827,-0.031560745,0.013598176,-0.0422624,0.051727407,-0.019206442,-0.100586936,-0.014942046,-0.009025321,0.019256115,0.014452015,-0.07825309,-0.024879657,-0.08906727,-0.025930258,0.09288918,0.0051596477,0.005135359,-0.06930011,-0.05607249,3.0779587e-33,0.049039435,-0.055336863,-0.052049454,0.066542774,0.0381144,0.024357624,-0.062325757,-0.0818124,-0.05883144,0.091042496,-0.0049360087,-0.0029848164,-0.045298863,0.05358539,0.01357731,-0.00084934325,0.032918096,0.082948186,-0.048337355,0.04432829,-0.03502265,0.03262471,0.034701448,0.015619947,-0.043247785,0.04095723,0.075880006,0.04625732,-0.04392194,0.0062494343,-0.056664005,-0.04218645,-0.0448698,0.00072899205,-0.008307954,0.09280502,0.04933413,-0.008224382,-0.090369135,-0.072017685,0.008934786,0.027738756,0.06372707,0.11036552,-0.047788206,0.063146785,-0.010233241,0.04925012,-0.1419637,-0.015413537,0.019709984,-0.012356336,0.0048931697,0.02310061,-0.035420682,0.031452928,-0.013010944,0.005018959,0.018378247,0.039112426,0.08904619,0.0032804285,0.010166594,-0.028867325,-0.008589243,0.03070519,-0.020097308,0.07060185,0.04192286,-0.044488523,0.15440263,0.041214593,0.031004786,-0.047774706,-0.039924398,-0.01917432,-0.053234044,-0.031802505,-0.099113494,-0.03832872,-0.045490295,-0.06393955,0.0018032282,-0.020293267,-0.024813527,-0.09387908,0.0053675184,-0.016477372,-0.046501778,-0.040518004,-0.024351759,0.054473087,-0.026018925,-0.0025034957,0.038448475,-1.2627989e-08,-0.04890512,-0.0025558071,0.04516902,-0.08231379,0.05146818,0.07129888,0.095667295,0.066709,-0.008879148,-0.108514555,-0.019248161,-0.01747319,0.0696478,0.014811474,0.15665421,0.052777648,-0.028634664,-0.0006102022,-0.07618068,-0.014642261,-0.08933536,-0.082944505,0.06106372,0.048799355,0.056054834,-0.0085427,0.06823678,0.08133627,0.057976406,0.05956672,0.08097787,0.050744645,0.040304184,-0.05734653,-0.07492166,0.07002506,-0.015852017,-0.037528187,-0.006534699,-0.041567184,-0.043070532,0.050068695,-0.07659841,0.018079551,-0.060858823,0.04043267,-0.008686554,-0.020996256,-0.0494879,0.06166204,-0.0002792656,-0.024740566,0.044004854,0.050557304,-0.102484345,-0.0028396118,0.050286174,-0.01376354,-0.02675304,0.008525962,0.04700998,0.031688336,0.07176816,0.020019233 +1.1.1.84,Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate.,384,0.99999994,0.0173262,-0.056516573,-0.027082354,0.005422234,0.083443455,0.075328685,0.031580005,-0.0012419628,0.01761655,0.056532122,0.02565145,-0.051043298,0.0125540495,0.07250801,-0.015932238,0.019577848,-0.031424057,-0.014097266,-0.03765912,0.010279108,0.10036892,0.010303177,-0.003886861,-0.046334915,0.05446697,0.032203488,0.036620684,-0.03969988,0.08700471,-0.064063326,-0.011465063,0.03531686,0.020532364,-0.03294374,-0.067833304,0.08529392,-0.0490037,-0.04112026,-0.0193114,-0.009290568,0.02606121,-9.699631e-05,0.0671588,-0.06737986,0.0068240263,-0.02399901,0.020247221,-0.02462442,0.063075274,-0.045020938,-0.0899159,-0.060450673,-0.060726423,0.097227916,-0.014870535,0.030435065,-0.16436672,-0.020047897,0.009793063,-0.052243248,-0.0027659198,-0.041276753,0.026179286,-0.0075372295,0.061583146,-0.014477697,-0.004017007,0.0018138605,0.025262445,-0.0022960177,-0.02973168,-0.04084792,-0.067932755,-0.013917477,-0.015745929,0.053968772,0.0051975683,-0.07452009,-0.00030698167,-0.020996219,-0.047898017,0.09714064,0.035921767,-0.008472715,0.025684575,0.075345024,0.022623926,0.013362443,-0.0011785635,0.0025469156,0.078287415,-0.014888633,0.02393264,0.031179402,-0.023959612,-0.0040504024,0.052418996,0.01758821,-0.010029689,0.031447537,-0.024195828,0.029921439,-0.046841387,-0.015302833,-0.07462474,-0.023022579,0.04279558,0.015851928,-0.01827697,0.017380156,-0.011285852,0.0044502756,0.023423975,0.054542724,-0.036785975,0.044575185,0.053607915,-0.10246173,-0.087023005,0.01371021,0.0142461555,-0.036589503,-0.04672479,0.060016513,-0.050998714,0.00090050197,-0.0604517,1.2913588e-33,0.093124874,0.04292346,0.07212274,-0.011006842,-0.03306151,-0.002428866,-0.13473327,-0.05212192,0.04184028,-0.07579557,-0.11039187,-0.06606793,0.04790146,0.008098415,-0.024417574,-0.0037040643,0.026037186,-0.056435276,0.065311834,0.037517816,-0.009520424,0.022767147,-0.08071297,-0.037892714,-0.027425151,0.07531549,0.10332869,-0.014195206,0.06102673,-0.005015285,0.07488073,0.006311973,-0.04013001,0.07439664,0.01981041,0.08077649,-0.11477257,-0.0056167804,-0.02905215,-0.0035558126,0.017035577,0.02588743,-0.10926577,0.06460993,0.04344207,-0.10441295,-0.028913455,0.10354361,0.01426212,0.10026047,-0.021804985,0.04408202,0.025032612,0.04426033,-0.019264335,0.04283865,-0.0040249787,-0.016365258,0.012112662,0.04152173,-0.06599864,-0.03339078,0.035656426,0.03489995,0.024315277,0.028184157,-0.11242867,-0.079772785,0.0007669067,0.0038976842,-0.026300406,-0.04809538,0.07239714,0.11711627,0.00048508545,-0.0545964,-0.028195184,-0.06828295,0.013878071,0.09979407,-0.036047716,-0.04479809,0.020697936,-0.031872172,-0.07738957,-0.0741014,0.0039223684,-0.07620187,0.023371773,0.017701898,0.031626053,-0.019671567,-0.043195467,-0.0181871,-0.03303574,-3.3508227e-33,0.04401334,-0.058545567,-0.010444743,0.028052878,0.0021959732,0.053222094,0.022385655,-0.14962254,0.007452052,-0.0016481853,0.10443409,-0.0019063666,0.0058166147,0.004485241,0.030516049,0.003146258,0.004082284,0.055702306,0.02681857,0.037524756,-0.059199177,0.10350156,-0.032583166,0.032266367,0.014413029,0.074351884,-0.05137352,0.011610262,-0.018737338,0.059284385,0.03458447,0.022881087,-0.10007994,-0.11096787,-0.03176951,0.00035942913,0.024346188,-0.037544247,-0.036006585,0.035841394,0.03411368,0.009629951,0.050979532,0.06523934,0.0010792791,-0.029774314,0.07238424,-0.02660675,0.015465172,-0.04664364,0.08249327,-0.036638238,-0.058025416,-0.028516585,0.07181751,0.048559997,-0.021409102,0.07011167,-0.012161499,-0.07288485,-0.025954677,-0.09108666,0.036369048,-0.11242819,-0.0065896944,-0.03421919,0.023029182,0.043847773,0.097741246,-0.03163511,-0.0015728124,0.08084182,0.118351445,-0.0036983993,-0.026836107,-0.09001221,-0.0956693,-0.0442158,-0.00028962066,-0.1045517,-0.025721323,0.050371632,0.006862478,-0.10425394,0.018495489,-0.05258236,0.0045712776,0.050370358,-0.060615107,0.05144621,-0.038760766,-0.0033964254,-0.025797391,0.12661278,0.07458925,-2.8738752e-08,0.055528075,-0.022911917,-0.018056978,-0.05893581,-0.019385662,0.026430355,0.06729348,-0.060426902,-0.003848443,-0.028744876,0.036037534,0.06534597,0.018882874,0.003920769,0.063707896,-0.061138567,-0.04271199,0.077324204,-0.089659914,-0.08569567,-0.038296923,-0.014571504,-0.086045265,0.06253821,0.05928604,0.00016951034,0.057219487,0.048016313,-0.008828027,-0.07271383,0.070345424,0.03201075,0.028176928,-0.07642951,-0.06469196,0.06353552,0.042309094,0.013342007,0.008944219,-0.0051393807,-0.039480865,0.027824886,-0.07005114,0.031364985,-0.010286577,-0.015000308,-0.048079718,0.0051264465,-0.038163308,-0.06390543,0.037465215,-0.0068857325,-0.030978456,-0.05166552,-0.018982148,0.02080884,0.008321594,-0.009767808,0.031632047,-0.090344615,0.026204482,-0.05074929,0.0132629415,-0.051348433 +1.1.1.85,The product decarboxylates spontaneously to yield 4-methyl-2-oxopentanoate.,384,0.99999994,0.023207493,-0.04989114,0.0020604872,0.014263351,0.048597917,-0.022837454,-0.045773264,0.018210392,0.031069458,-0.007429648,0.042070754,-0.061942916,-0.046619717,0.009401221,-0.026269557,0.12463826,-0.06725886,0.0041193855,-0.0053350907,0.048954535,0.05080776,0.03829089,-0.00055801426,-0.047972325,-0.012397704,0.041270893,0.029434543,-0.02753931,0.033356547,-0.07688397,0.053210896,0.003639434,-0.012295367,-0.057824656,0.059279088,0.091630556,0.010008513,-0.051545624,0.04604766,0.048327453,-0.0016563871,-0.02435798,0.01532362,0.021550685,-0.039710402,-0.041985493,0.07737883,-0.024101997,0.014508382,0.01534478,0.0014800797,0.021070134,-0.045513414,-0.0058987606,0.028336065,-0.046291694,0.02732521,0.03379103,-0.08465961,0.025145637,0.0707239,0.010397776,-0.04135785,-0.070805505,-0.045005046,0.0406019,0.010796701,-0.01027368,0.045374684,-0.036720738,-0.06504054,0.013730965,0.028365957,-0.017434455,-0.07247134,-0.013636451,0.014056057,-0.09871853,0.067047164,0.035872817,0.08760571,0.02404002,0.051414546,-0.021370945,0.023607899,0.03945725,-0.0031505628,0.018787045,0.080855966,0.056803364,-0.06573236,0.025248956,-0.037909105,0.05007758,-0.0022403984,-0.029203188,0.05708871,0.08384186,0.04193739,0.017286105,0.060078792,-0.0073522106,-0.05592613,-0.08741099,-0.0012111596,-0.037080992,0.015226811,0.011009775,-0.034710083,0.066301756,0.0008000236,-0.027746605,0.052093897,0.022728859,-0.067090474,0.14324635,-0.045545373,-0.01773276,-0.06866013,-0.047005575,0.019662771,0.07192461,0.038364343,-0.026547557,-0.089254655,-0.03560939,-0.08731696,-2.070527e-33,0.0008535472,-0.004532522,0.050980076,0.057910908,0.023915103,-0.048303068,-0.08381623,0.004333637,-0.028115682,-0.0067384974,-0.05321423,-0.06846616,0.007475877,0.025996638,-0.038616296,-0.09946421,-0.022900483,0.052329034,-0.00090824394,-0.03408952,-0.012672197,0.09290499,-0.029240137,0.00891005,-0.07236611,-0.038670175,0.06943378,-0.032823097,0.061419155,-0.012523082,0.008582549,-0.100961134,-0.021303877,-0.04516851,0.017453816,-0.020365821,-0.07679652,-0.029927125,-0.015304644,0.01848936,0.049822398,0.029035503,0.0066658906,-0.037496712,0.06573939,-0.0686156,-0.044115037,0.08769572,0.010671526,-0.034081984,-0.016023586,0.00035443995,-0.06530456,0.02981711,-0.087827645,-0.07813827,-0.07473551,-0.009040223,0.05187789,0.008706364,-0.045447007,0.04263759,-0.05035862,-0.07216491,-0.03486445,-0.020849142,-0.0330011,-0.034454692,-0.058466364,0.06948197,0.048312187,-0.07573599,0.04558124,-0.031853374,0.07948765,-0.03185198,-0.0027718572,0.035835423,0.101562314,-0.029423285,0.07899548,0.04743675,-0.0136207,-0.035630044,-0.11281421,-0.027065912,-0.04552369,0.069461726,0.00094678137,0.15322633,-0.01396827,-0.067399934,-0.054027937,-0.02608465,-0.0028861924,2.9842082e-34,0.01733115,-0.007610923,-0.030622091,-0.038315903,-0.005971672,0.041009784,-0.015541084,0.013720388,-0.013417434,-0.015946304,0.052900277,0.07471686,0.0638962,-0.015805585,0.041465834,-0.037516203,0.038960945,0.10276602,0.033390243,-0.007342298,0.08624166,-0.011700512,-0.02360089,0.032514796,0.07648644,0.041577194,0.08825432,-0.012845725,0.068148516,0.095439084,-0.019779095,0.010011618,-0.01796988,0.0058243936,-0.037842557,0.05215149,-0.03902214,-0.07960375,-0.05369185,0.0641255,-0.096830234,0.00082836876,-0.022491131,0.09426118,0.027376825,-0.016970214,-0.072012655,0.012438939,0.089674115,-0.04929726,-0.012767489,-0.004935496,-0.06717872,-0.07376112,-0.012011835,0.076274656,-0.052954145,-0.016094243,0.079391025,-0.032216396,-0.04723267,-0.019559307,0.011772188,-0.09519063,0.009199567,0.039740503,0.02742934,0.028353198,0.029795486,-0.07836964,0.058625605,0.078436926,0.032873385,-0.04135478,-0.0013587142,-0.048216566,-0.10305887,-0.06594138,-0.03743968,-0.041976325,-0.041095056,-0.025199441,0.10685752,-0.034168784,0.016324192,-0.098741636,0.061193578,0.0600171,-0.040239956,0.052058212,0.005368376,-0.032753516,-0.069100976,0.18233794,0.055300314,-2.450852e-08,-0.053205315,-0.08167341,0.0723413,0.011771096,-0.09976244,0.11379099,0.062108774,0.049961317,0.02615823,-0.06527945,0.023075275,0.044470295,-0.027122898,0.07259628,0.032375418,0.047083855,-0.069025874,0.033824854,-0.021432083,-0.016606748,0.017039308,-0.007907134,0.03166101,0.011274344,-0.09026955,0.011781643,0.05829797,0.087763414,-0.00020162213,-0.031756494,0.04007459,0.054964572,0.014388687,-0.052898716,-0.09341292,-0.007365023,-0.028330304,0.004593314,-0.042139586,-0.0036766217,0.0026154094,-0.021044595,-0.014310142,0.071359925,0.023146667,-0.03154726,-0.04009442,0.0870452,0.0013900397,-0.027173078,0.08281504,0.02598972,-0.02276623,0.02169886,-0.009288187,0.03182575,-0.06141717,-0.027353901,0.0023083265,-0.021692831,-0.049955238,0.010323115,0.15257674,-0.04570356 +1.1.1.86,"Also catalyses the reduction of 2-ethyl-2-hydroxy-3-oxobutanoate to 2,3-dihydroxy-3-methylpentanoate. The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382, ketol-acid reductoisomerase (NAD+) and EC 1.1.1.383, ketol-acid reductoisomerase [NAD(P)+]).",384,1.0,-0.012686699,0.0013156096,-0.03535338,-0.0155772045,0.047233704,0.057426274,-0.084143996,0.024642114,0.044476368,0.03865018,-0.018410768,-0.055910766,-0.07803234,-0.010478758,-0.023046367,0.045779437,-0.052607838,0.06512012,0.05787482,-0.029953431,0.07904763,0.024764469,0.014660572,-0.034032233,0.054216117,0.08228891,0.01898879,-0.027749348,-0.025568467,-0.10996881,-0.037528347,-0.077188484,0.029118106,-0.08328332,0.04988546,0.07397759,-0.06901319,-0.042554345,-0.0021154545,0.033303224,0.056952003,0.009408094,-0.00084035203,-0.013677871,-0.0129172355,-0.013942955,0.0028896371,0.054765895,0.05467472,-0.03493208,-0.041561875,-0.043307997,-0.03569334,0.07087949,0.07415475,-0.0314147,0.05989116,-0.020531815,-0.02917442,-0.029369107,0.076399885,-0.033859033,-0.016633702,-0.01100896,0.0261105,-0.059746753,0.08093308,-0.0968284,0.013083136,-0.06534299,-0.13043423,-0.024469765,0.033558317,0.022282314,-0.013929561,0.025970332,-0.027629191,-0.014024393,0.032901417,-0.026321413,0.064340495,0.029845556,-0.041900765,0.048670612,0.059336204,0.0118982615,-0.04676168,-0.05878611,0.043184772,0.02030428,0.0071728206,0.016089635,-0.010412322,-0.009604061,-0.149874,0.021039028,0.045106795,0.08755065,0.028839119,0.0016657381,0.028906157,0.11265207,-0.051701892,-0.12739588,-0.094325535,0.023258973,-0.029438546,0.07412033,-0.00017531957,0.038159665,-0.040064037,-0.04656736,-0.03652697,-0.0019669565,-0.054741398,0.12907356,0.04688209,-0.07936636,-0.09759005,-0.033408545,-0.015130102,-0.031724975,0.071185164,-0.025168385,-0.031266607,-0.010228381,-0.13552225,2.0265793e-33,0.09291988,0.056940638,-0.031850543,-0.0056746243,0.08078566,0.050085507,-0.08189099,0.05667584,0.018835077,-0.064572304,-0.035432704,-0.03525061,0.03842455,-0.034954242,-0.011321033,0.0018428342,-0.045043033,-0.008546022,-0.022786502,-0.021775154,0.03433367,0.018868564,-0.034169443,-0.0027546377,-0.0036616465,-0.011582714,-0.008980566,-0.010045642,0.042093754,-0.0030770728,0.043665692,-0.08981846,-0.11517399,-0.0043432117,0.07822175,-0.05020917,-0.07019582,-0.031013533,-0.043939978,0.10812192,-0.06349486,0.03544536,-0.0033820989,-0.06526185,0.071406394,-0.09923451,-0.021214604,0.09787954,0.082800664,0.05798503,0.056746382,-0.037254605,0.09431956,-0.025202323,-0.038741812,0.049357478,-0.046845295,-0.017410232,0.014166359,0.014840169,0.029159725,0.077994674,-0.0013829375,0.016403425,-0.055497233,0.02584804,-0.037361074,-0.005566293,0.036957216,0.037425764,-0.01655326,0.036393065,0.07843378,0.04737055,0.011086767,-0.057147842,-0.059703194,-0.007844972,0.042569138,-0.024771022,-0.00029433522,-0.026935974,0.034285605,-0.014632733,-0.031682413,0.026631897,0.0055724513,-0.009232462,-0.034729145,0.022447845,0.083415255,-0.034620315,-0.06772406,-0.025082642,0.018230323,-2.5613625e-33,0.09642738,-0.06984438,0.027455412,-0.13954975,-0.019937964,0.045920167,0.01964593,-0.030803708,-0.011852735,-0.054543756,0.08163001,0.060217228,0.0826896,-0.008667729,0.08045428,-0.05728272,-0.007215082,0.049416155,-0.009748617,-0.021298608,0.107879706,0.028560035,-0.04165031,0.018111696,0.022871234,-0.036082383,-0.015453894,0.03797031,0.06699499,0.036227044,-0.01651873,0.012357401,-0.049768556,-0.03713957,-0.014657854,0.060147405,-0.06188706,0.009498158,-0.032295838,0.07532492,0.009130573,-0.0023338967,-0.07529524,0.0031081636,0.07310274,0.0649252,-0.122881964,-0.0025487056,0.08848712,-0.06216108,0.078549735,-0.014099373,-0.03697122,0.013676654,0.058594942,0.039778404,-0.04397809,0.044608142,0.046756603,0.018314306,-0.06764282,-0.05903346,0.05724644,0.01684024,0.06326676,0.04054097,0.03494089,0.05375724,0.0047872374,0.015855124,0.051298067,0.05555552,-0.00043104668,0.017724251,-0.031939827,-0.08075157,-0.035939068,-0.02172321,-0.0446467,-0.02715721,0.075602956,-0.027914306,0.022375254,-0.08376827,-0.022344884,-0.049648978,0.015600186,0.06995149,-0.073380694,0.032613445,-0.017740957,0.045775298,-0.08883123,0.08013498,0.01977706,-4.571935e-08,0.037568685,-0.04391071,0.056085926,-0.008356124,0.021704651,0.055672634,0.014362333,0.027955988,0.042112984,-0.048308115,0.004548151,0.09482461,0.06987342,0.03902565,0.06795374,-0.0072475234,-0.030844737,0.01629756,-0.023775548,-0.011156247,-0.03726478,-0.012342632,-0.07658277,0.017719327,0.04307635,-0.04740063,0.020452345,-0.005866393,-0.0076421355,-0.05953305,0.006270991,0.02007897,0.09017472,-0.016165815,-0.060498245,0.03241019,-0.06022464,0.005784367,-0.07738051,0.027901115,0.006214683,-0.03573077,-0.06623212,0.049024045,0.040028445,0.0070904773,-0.008659425,0.028230898,-0.059471518,-0.01876821,0.049646694,0.009670796,0.015359163,-0.056607135,-0.10954003,0.017020777,-0.011235077,-0.039507546,-0.0726646,-0.050311446,0.056683104,-0.028068313,0.15966637,0.04833466 +1.1.1.87,Forms part of the lysine biosynthesis pathway in fungi [3].,384,1.0,-0.010089524,-0.08738727,-0.14679587,-0.025465332,0.12163094,0.06239889,-0.10429173,-0.013993378,0.057951316,0.032291193,0.07457026,-0.046591453,-0.029525947,-0.038103744,-0.032705396,0.0473494,-0.15928963,0.035541985,-0.008489668,-0.014362612,0.10979043,0.12787646,-0.017554233,0.027335653,0.047415935,-0.08436236,0.05967785,-0.03002474,-0.026328439,-0.04815229,-0.039428264,-0.0025619818,-0.00030798194,-0.10093361,0.043698464,0.07178223,-0.043652695,-0.01684425,0.13038835,0.034634214,-0.027249178,-0.06852979,-0.014937721,-0.018261043,-0.09163882,0.065007076,0.008146581,0.02721723,0.014187279,0.0056706504,-0.043690123,0.017546527,-0.014854278,0.019972239,-0.022545291,0.010502228,-0.04954708,0.040383298,0.03445773,0.027844634,0.021733698,0.010017674,0.03142897,-0.020520044,-0.016308011,-0.06646373,0.011225255,-0.034990072,0.0043814704,-0.07756185,-0.060073823,-0.10172221,-0.008230352,0.0076823053,0.052921925,0.10509014,0.01030324,0.024828251,-0.03220726,-0.03041305,0.022408292,0.0059409672,0.027621135,0.06928263,0.010872375,-0.08089416,-0.017656632,0.058694366,0.025974758,0.014850692,0.0849367,-0.039660674,0.016029702,0.046091657,-0.036811493,0.07369741,0.08031087,-0.009460414,0.03179202,-0.07310384,-0.01375716,0.010443264,-0.010739305,0.04410076,-0.00092211715,-0.026285298,0.030035857,0.08662848,-0.03431816,-0.049046423,0.028800046,-0.0029814502,0.05124862,-0.01670712,0.018560842,0.017621951,-0.0033685027,-0.029450335,-0.028420147,-0.01134351,0.031918075,0.05154498,0.0045879977,0.04908794,-0.030746879,0.019497527,-0.09151115,-1.9811034e-33,0.09266793,0.089015074,-0.07227674,-0.03503713,0.012231483,-0.00911093,-0.036544744,-0.030536335,0.0010906336,-0.012693954,-0.09472114,-0.08379725,-0.0039295377,-0.01996354,-0.07937941,0.028331848,-0.023915065,-0.06546417,0.041800447,0.08447322,-0.013058277,0.035994183,-0.057992678,0.02260018,0.03267467,0.056845386,0.043931622,-0.0052346117,0.006155336,-0.010240853,-0.014639417,-0.14486107,-0.019109214,0.030208068,0.08020626,-0.024137862,0.026425915,-0.050462216,-0.017565317,-0.014828548,-0.0014819374,0.030106127,-0.016402707,-0.056383017,0.03141485,0.07272082,-0.046298843,0.07402075,-0.020038625,0.030774336,0.055334594,0.011395807,0.14252828,0.014944927,-0.08082111,-0.05786241,-0.069958866,-0.0278649,0.012812874,0.040206626,0.017399486,0.083439946,0.033013053,0.06486891,0.019200053,-0.013776571,-0.09810567,-0.04702895,-0.000579457,-0.013190976,-0.061077196,-0.035776656,0.013586901,-0.022323782,0.065549046,-0.0060206624,-0.11315863,-0.026356485,-0.03318294,-0.00014158766,0.012163231,-0.0030374634,-0.0383097,0.020260626,0.008640333,-0.020906148,-0.02355058,-0.0856128,-0.017633295,-0.015129241,-0.03665925,-0.046365652,0.022295453,0.08325452,-0.016566234,-6.3886525e-34,0.11083941,-0.065150335,0.09270657,-0.04884458,-0.040130995,0.085048735,-0.029238446,-0.008017843,0.017996375,0.0012648812,0.030197704,-0.01412268,-0.03596908,-0.05719736,0.0066886204,-0.013604014,0.06272017,0.09863161,0.02336415,0.011971247,-0.0027733461,0.06351609,-0.039720524,-0.003567147,0.06595806,0.0143489195,0.0010767519,0.08189762,-0.022972511,0.03963519,-0.0068361103,0.03211274,-0.017172256,-0.069709636,-0.028499687,0.043647837,-0.031582665,-0.027903667,0.038805675,0.009475936,0.033764064,-0.04283225,0.01480924,0.04811172,0.0366973,0.011874625,-0.03369385,0.05029774,0.006134779,-0.059403226,0.0011411278,-0.036594424,0.034610216,0.027816769,0.025013754,0.030284222,0.030984107,0.053693395,0.01457676,0.0013231961,-0.035641566,-0.00085788156,-0.03730201,0.017691068,0.06985165,0.013381482,-0.06182233,0.045346346,0.08883774,-0.019970786,0.11636238,0.038229335,0.071789116,0.09576154,-0.0055280407,-0.00080543465,-0.062924474,-0.0951493,-0.002770043,0.03228335,-0.016422229,-0.014133686,0.07621048,-0.06870831,-0.060742434,-0.095898755,0.040694825,0.084630966,-0.019339122,-0.008010221,0.015416742,-0.033762865,-0.018229952,0.055335265,0.07560254,-2.300682e-08,0.079944424,-0.022691088,0.034012966,-0.09816582,-0.04114813,-0.024587534,0.06731599,0.067738146,0.005859175,0.015904678,-0.043045834,0.008807251,0.005927783,-0.008446315,0.06329478,0.031577792,-0.009637215,0.08551293,-0.029070051,0.01836821,-0.007974063,-0.052856185,-0.09671035,0.011264989,0.03902022,-0.08271982,-0.012837143,-0.058298673,0.039908983,-0.040627938,0.050805785,-0.013746805,0.03315503,-0.0893139,-0.12513521,0.004842439,-0.092352815,-0.09454124,0.05799007,0.011987252,-0.040783875,-0.011853941,-0.0869544,0.010986385,0.015982093,-0.021046922,-0.04057968,0.051193427,-0.0070118997,-0.057896655,-0.0014574507,-0.016229643,0.017969303,-0.051721197,-0.035275966,-0.03485819,-0.005926398,0.005715764,0.016493255,-0.07268312,-0.070851386,0.06545434,0.1560093,-0.071027935 +1.1.1.90,"A group of enzymes with broad specificity towards primary alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity towards short-chain aliphatic alcohols.",384,1.0,-0.019518333,-0.06841139,-0.053480487,-0.014658768,0.037347455,0.06801209,-0.038014892,0.008070956,0.04429449,-0.079417266,0.022274727,-0.049936693,-0.0659427,0.07591299,-0.04318521,0.05149828,-0.08947514,-0.03340411,0.012616622,-0.031537015,-0.066067904,-0.0018623448,0.03268241,0.050713725,0.0066583757,0.013833064,0.019654874,0.008728157,-0.015831515,-0.05989534,0.03467149,0.038817484,0.08866132,-0.019681709,0.051264886,0.06216557,-0.010983571,-0.013765679,0.022605618,-0.03273608,0.045462303,0.055759404,-0.060479198,-0.03222038,-0.06866908,-0.04715519,-0.0052605392,0.010026384,-0.05554545,-0.03511076,0.037561543,-0.08290989,-0.03219727,0.09654502,0.095592044,-0.00931695,-0.076604776,-0.059437666,-0.06655774,0.024692584,0.09991779,-0.010518614,0.032593824,0.07364115,-0.011732858,-0.0069847684,0.024622232,0.0684645,-0.05140732,-0.0019285181,-0.08320435,-0.1449875,-0.08851201,0.118790604,0.013901699,-0.0675304,-0.03746668,-0.002094229,-0.03142569,-0.072870046,-0.020764267,0.0006762458,-0.02759486,0.060696103,0.05774132,-0.026283368,-0.010934596,0.00462353,0.016101234,0.037455145,-0.051917102,-0.06658388,0.035413686,-0.101367846,0.089592196,0.0371937,0.046829488,-0.023322731,-0.035686933,-0.0065827304,0.020602576,0.07969413,0.015834393,-0.10627519,-0.04998154,0.00034206585,-0.0016994732,0.003561555,0.032938957,-0.016990175,-0.055350978,-0.05631705,0.108723514,-0.1124275,-0.031103224,0.07470913,0.026457572,0.01750029,0.05042326,-0.033107992,-0.028027512,0.017801458,0.04996028,0.04942515,-0.010810377,0.09012221,-0.07715957,-1.134321e-33,0.062266707,-0.058677536,-0.010015328,-0.011684639,0.025364146,-0.09845053,-0.01588271,0.009092815,-0.07536042,0.019801572,0.04224666,0.03024544,0.026490415,-0.020318713,0.08328175,-0.020942496,0.009343192,0.051704824,0.056521505,-0.06285692,-0.0980352,0.01735953,-0.070487365,0.05306991,-0.007101394,0.027611054,0.0337487,0.010351637,0.009394123,-0.027747193,-0.022750556,0.051001463,-0.05845538,0.0273919,0.0052812374,0.05246663,0.004922871,-0.04628067,0.010910367,0.013716661,-0.03918076,0.031519014,0.037320953,-0.062189408,0.020641757,-0.005370005,-0.10776925,0.056665197,0.00014528437,0.05764869,0.028628267,-0.052206177,0.0538285,-0.016590975,-0.08154455,0.12819271,-0.05586423,0.05823695,-0.0044684,-0.0013602604,-0.056064922,0.030920204,-0.1346403,-0.048957366,-0.01886116,0.0049470225,-0.07634997,-0.082786754,-0.036880095,0.07486572,-0.0807368,0.015115873,0.019091187,0.018141445,0.08530849,0.008740638,-0.053380087,-0.03301672,0.020388594,0.06387986,-0.097770534,-0.030738333,0.007769829,-0.049616497,-0.033794552,-0.06425121,-0.026816878,-0.017002195,-0.008157818,0.013130933,-0.068653226,-0.009404024,0.010562751,0.11912185,0.016835788,-2.352654e-33,0.057928767,-0.12620254,0.032825574,-0.0616785,0.03958906,0.06365423,0.0222551,0.0037521315,-0.013879444,-0.010711563,0.051699962,0.017202338,-0.0005115815,-0.054782,0.0002544736,-0.034334112,0.018143501,0.07682027,0.08467706,0.02726056,0.061784033,0.031484775,-0.048258185,0.0058001606,0.029056186,0.031120447,-0.058649085,0.049708355,-0.031444836,0.023157855,-0.026747597,-0.0039845677,0.01320531,-0.03947732,-0.049135413,0.097213164,-0.00048622032,-0.016098594,-0.07299429,0.030952537,-0.015084505,0.06858522,0.008205432,0.033520922,0.082568966,0.0059001027,-0.090606816,0.008466526,-0.038550057,-0.061351225,0.0123369675,0.08569305,-0.0039420323,0.05440345,0.049432423,0.03644273,-0.023277096,-0.005229039,-0.04046709,-0.021974893,-0.03949128,-0.03681375,0.024813313,0.053080253,-0.0129491445,-0.027495304,-0.08657458,-0.046652548,-0.03571724,-0.009607438,0.07508981,-0.06875649,-0.0071333013,0.042660985,-0.040659465,-0.08217081,-0.08705027,-0.10014861,-0.03344026,0.006360403,0.02447326,-0.0015890717,-0.04616651,0.007714201,0.011696992,-0.07308817,0.015455071,0.040504716,0.018100545,0.036486976,0.006992386,0.024406187,-0.041125506,0.07636684,-0.040762477,-2.9288913e-08,0.05438318,-0.030737042,0.04421225,0.04490323,0.03944219,-0.045193907,-0.008439018,0.005072013,-0.01764628,-0.016832523,0.013967926,0.102432385,-0.045931675,0.055946566,0.07376638,0.028299345,-0.019951459,0.030387936,0.009971634,-0.033521745,0.02898571,0.071854174,-0.04903471,-0.034042425,-0.044053808,-0.06722573,0.033102855,0.030630054,0.013735107,-0.027015405,-0.007934971,0.08444127,0.029869303,-0.013134491,-0.008243032,0.026991136,-0.09417293,-0.051644485,-0.066952676,0.055210497,0.0145390695,-0.049122155,-0.07656758,-0.033486463,0.015158892,-0.004985604,0.04211266,0.023144701,0.008426832,0.029502561,0.08378117,0.02311445,0.03929489,-0.03736439,-0.06991772,0.08619452,0.010119155,-0.022605889,-0.020069351,-0.1059276,0.06650023,0.022911033,0.19961093,0.03872566 +1.1.1.91,"Also acts on some aliphatic aldehydes, but cinnamaldehyde was the best substrate found.",384,1.0,-0.009551691,-0.0856062,-0.033315614,-0.007098334,0.10741069,0.05860109,-0.051919073,-0.008609781,0.01654517,-0.006048152,0.034724392,-0.014995791,-0.057875942,0.08816401,0.012021246,0.08011747,-0.01489239,-0.015527615,0.00671902,-0.00020828919,-0.013782911,-0.021021098,0.008271265,-0.007025694,0.034367595,-0.0072993664,0.015950892,0.025826719,0.06449215,-0.09413081,0.024837956,0.012666586,-0.016805125,-0.071866855,-0.013411567,-0.0049483613,-0.09768785,-0.0141735915,0.04502944,-0.043385603,0.007056059,-0.015028878,-0.03081815,-0.037256848,-0.067432605,-0.05024346,0.102003746,0.06398166,-0.032247603,0.013264071,0.018643536,0.0015884797,-0.031218542,0.0013667069,-0.0031521567,-0.068292364,-0.0945588,0.053130724,-0.006509811,-0.01411046,-0.003151616,0.024697082,-0.065735474,-0.00654798,-0.06991675,0.0072352397,0.037119288,-0.020248508,0.037280113,-0.021214927,-0.06220216,-0.07575429,-0.02749056,0.04958955,0.044341408,0.06845978,-0.007660031,-0.11174143,0.0316538,0.021942355,-0.07618183,0.076910086,0.042654023,0.08694756,0.09742803,-0.037295558,-0.02907507,0.010060501,-0.07529809,0.027801814,0.033938807,0.07335557,-0.03638082,0.01644613,0.032087613,0.043110862,0.057527658,0.05695773,0.06708673,-0.013063699,-0.05093541,0.0362656,-0.07804821,-0.077746436,-0.08810691,-0.0028969906,0.017128613,0.021593241,-0.0406609,-0.046903733,0.008954482,-0.017289765,-0.0055830455,-0.035320185,-0.048900504,0.04657392,0.08960035,-0.017595137,-0.051074374,0.0038473115,-0.039147303,0.018320879,0.027120909,0.07344328,-0.057235353,0.07262445,-0.010572851,8.879832e-34,0.0025966607,0.0071055014,-0.030976994,-0.05060001,0.073173195,-0.04914878,-0.097507,0.06690815,-0.02413165,-0.041566733,0.02224799,-0.06375752,-0.0011393306,-0.0070261224,0.0022726145,-0.008506077,-0.090025485,-0.08096024,0.0050369976,-0.025376437,-0.020921111,0.02439716,-0.047645375,0.017327394,0.00017377167,-0.016061045,0.015090878,0.01996275,-0.03752359,-0.024894452,0.040449914,-0.018888777,-0.07484426,-0.0053180456,-0.022634309,0.099031754,-0.10566848,-0.016002763,-0.044169564,-0.0032837992,0.041330703,0.048983708,0.04118169,-0.06553761,0.042665705,-0.040927183,-0.11536571,0.10782968,0.025586948,-0.030086922,0.07046786,0.019459335,0.06222741,-0.0137572335,-0.070749596,0.07397476,0.0204572,-0.03970696,0.015486976,0.044350196,-0.093520805,0.016325856,-0.010891283,-0.0041825282,0.0053197662,-0.018745542,-0.04936265,0.012768146,-0.093563475,-0.028852629,-0.021053473,0.004917794,0.098219804,-0.032254685,-0.03537095,-0.0222325,-0.09183974,0.01899876,0.07302337,0.00019003016,0.031861644,-0.03531693,0.012048727,-0.09480649,-0.11415823,-0.054128334,-0.04025404,0.035511717,0.032755338,0.054168984,-0.0026889935,-0.02273653,0.0054034363,-0.0033502863,-0.046299733,-3.651737e-33,0.08008876,-0.14060356,0.05720521,-0.0021402643,0.0067539206,0.042640556,0.01016422,-0.034999005,0.039184123,0.010720287,0.07634044,0.029053152,0.001278609,0.02920217,0.023458859,0.038965754,0.024489662,0.06087729,0.07653448,-0.051020768,0.015572399,0.124979004,-0.007872637,0.038105045,0.06993492,-0.001962814,-0.008275014,-0.0036762082,0.07135051,0.08306002,-0.03643456,0.001972564,0.010412648,-0.091750585,0.02614925,0.038372193,0.0027166468,0.015748734,-0.09499749,0.055890832,0.027638836,0.01009299,0.044971853,0.10287768,0.05150013,0.07420431,-0.09509606,-0.019134495,-0.067601964,-0.032799788,0.06549552,0.05195284,-0.073225915,0.0016896401,0.024908375,0.12590247,0.027439924,-0.077621005,0.0509928,-0.030899337,-0.080288395,-0.011901914,-0.07768021,-0.10787774,0.01921187,0.013512648,-0.052554265,0.08544633,0.011609106,-0.038499855,0.06384447,0.015949143,-0.0067359544,0.03607637,-0.04154144,-0.06293865,0.031635523,0.02821838,0.0059769675,0.036936723,0.028004494,0.006424585,-0.017261319,-0.021109343,0.034972254,-0.020401644,-0.041305516,0.024580332,-0.030739369,0.043014172,-0.036386885,-0.010391666,0.018091613,0.041372426,0.038781784,-2.6313396e-08,-0.026231162,0.017733416,0.058785457,-0.009269953,-0.08319663,-0.017177805,0.11225413,0.07018767,-0.034313563,-0.06639911,-0.03745601,0.031961653,0.07405973,0.08268376,0.06993321,-0.07171309,-0.055490185,-0.003771207,-0.041139975,-0.05766996,-0.085720226,0.030383216,0.002801131,0.028368294,-0.08892757,-0.04474159,0.060843017,-0.016163088,0.0043014316,-0.011921865,-0.046126425,0.078548945,-0.04820178,-0.08328442,-0.009470043,0.06994915,0.011191382,-0.12663648,-0.02601601,0.012737323,-0.018524416,-0.061130702,-0.040496707,-0.010197198,0.05468652,-0.034658387,0.0041010384,0.056903444,-0.013777252,0.038908634,0.11642803,-0.0029448748,0.011760346,0.0014721008,-0.053175244,-0.0647751,-0.008497576,-0.059557196,0.051187813,-0.07868388,0.07210009,0.038068462,0.1641926,0.015705978 +1.1.1.92,Also reduces hydroxypyruvate to D-glycerate and glyoxylate to glycolate.,384,1.0,-0.044338975,-0.018956669,0.022820018,0.078052506,-0.009479729,0.0154487975,-0.042987518,0.022322072,-0.041771688,-0.016781744,-0.07000348,0.0802585,-0.032665994,0.019194717,-0.010196088,-0.022816893,0.042632516,0.06820541,0.010252094,-0.014325957,0.11279331,-0.04965598,0.016427923,0.014876311,0.071367525,-0.0236889,0.04474876,-0.031930137,0.0453843,-0.024281252,-0.031537633,0.006908204,0.016411684,-0.040962208,-0.030322548,0.09427157,-0.004649777,0.036954965,-0.035775136,-0.05891308,0.05576404,0.035141736,0.016853185,0.016732723,-0.03744607,0.013941936,0.0361729,0.029225701,-0.003435732,0.023184024,-0.0538488,-0.044101387,-0.0859357,0.006066227,0.014960517,0.07504159,-0.037591286,0.06115339,0.026038503,0.029002951,-0.04150379,-0.021739744,0.037611883,0.018298307,0.03258532,-0.077409066,0.036568586,0.010371399,-0.015093588,0.013640636,-0.00082112005,0.015088907,0.068896726,-0.012505842,-0.009481479,0.029675579,-0.06960094,-0.057259515,0.05528122,0.019061573,0.060712002,0.04344562,0.03788566,0.14242938,-0.03360142,-0.032032017,-0.011407622,-0.10423123,-0.06513273,-0.054395504,0.027757179,0.01998183,-0.038678594,0.05740862,-0.12157656,-0.027460914,0.077119514,-0.013306501,-0.019316679,-0.036503583,-0.02405048,0.05778877,-0.0029394135,-0.071817316,-0.07408101,0.026421312,0.025582008,0.03125212,0.05634632,0.026338749,0.016865363,0.049402595,0.014187697,0.0731281,-0.08825114,0.02879802,0.034230307,0.0014166635,-0.06286183,-0.0063581774,-0.02306282,-0.074292846,0.066730924,-0.045903,-0.091656946,0.033654757,0.018199122,4.2072706e-33,0.033930846,0.0041564195,-0.017659014,0.01992042,0.057076916,-0.009629777,-0.101049736,-0.052058622,0.010341177,0.00027506537,-0.05253747,-0.030555874,0.037210677,0.10161422,-0.06707173,-0.023357878,-0.08739275,-0.0027992423,0.09284701,-0.043755848,0.07732431,-0.02024296,-0.007905273,0.03748353,0.0003438323,-0.026873276,0.0018108966,0.050123632,0.01409615,-0.025112033,-0.026508668,-0.076923564,-0.026561804,0.024204344,-0.030578261,0.07528183,-0.09456721,-0.1314236,0.034871634,0.04463924,-0.031970922,0.010649392,0.008526735,-0.0938494,-0.009677694,-0.026255013,-0.005718926,0.08914729,-0.024565713,0.07859452,0.09640433,-0.05463729,0.022559816,-0.020736197,-0.042181067,0.018573925,-0.014440846,-0.06708845,0.042192142,0.054295,-0.002654613,0.029856749,0.016252344,0.02253273,0.007238078,0.03795097,-0.07145741,-0.03464728,-0.06475039,-0.018583285,-0.051588725,-0.019742645,0.12278514,0.024808751,-0.03833464,-0.09401422,0.016754195,0.00083317637,0.041455407,-0.038407274,0.027783541,-0.044729225,-0.03420869,0.011356887,-0.016313815,0.050098307,0.0076892357,-0.031220295,0.051895257,-0.00097134075,-0.019397218,-0.0820636,-0.0062137237,0.025271486,-0.07720436,-5.229453e-33,0.041751564,-0.11515811,0.02734492,-0.0029386955,0.007600076,0.0049043978,0.053845193,-0.027924698,0.047299843,-0.056066044,0.053091366,0.046331767,-0.0056848894,0.031136954,-0.021355473,0.069994904,0.044594575,-0.04315858,-0.10347414,-0.042898588,0.023255248,0.053752333,-0.05000577,-0.013155447,0.063912064,0.0023679822,-0.018494915,-0.011268352,0.012277384,0.14817287,0.046688307,0.027569631,-0.10479516,-0.06703798,0.0047552465,0.083101206,-0.07641115,-0.046415906,-0.042936094,-0.03742742,-0.018735932,0.052578673,0.10272921,0.05294608,0.09922884,0.0952636,-0.053084478,-0.01488652,-0.03925567,0.046968024,0.0072585046,-0.003831266,-0.041168816,0.09026745,0.022495545,0.031521484,0.052702874,-0.048040435,-0.041122276,0.00642214,-0.0883986,-0.043473437,0.0059677702,-0.07750965,0.05096046,0.0250169,-0.05332164,0.0103158215,0.079832196,0.02664754,0.10959844,-0.007447321,0.0012619537,0.034103878,-0.024954762,0.04418363,-0.010169934,0.004334001,-0.084388435,0.009289545,0.013995495,0.063515976,-0.045026347,-0.087054245,-0.028167967,-0.0183524,-0.051429763,0.12809215,0.0071546095,0.06737535,-0.04273159,-0.09740044,-0.0100856405,-0.079111904,0.10784294,-2.6589795e-08,-0.038187165,-0.047065407,0.051442277,-0.037004802,-0.07576174,-0.04569308,0.03975868,0.08643925,0.019064993,-0.07688099,0.025212947,0.0650578,0.015860377,-0.014088521,-0.004907348,0.027713785,-0.001245955,0.057590906,-0.07318502,-0.007146522,-0.119489945,-0.074543655,-0.07284463,0.10368353,-0.010494932,-0.08076696,0.08849011,-0.0093806265,-0.034196965,-0.02441714,0.03899698,0.033977814,0.029460436,0.0107783815,-0.014189888,0.047022864,0.04825567,0.04038936,0.023944227,0.012248101,-0.05041381,-0.09798909,0.010057382,0.040241133,-0.008978061,-0.036380082,-0.005208554,0.052782577,-0.028302625,0.0669003,0.03508899,-0.026879627,-0.04360375,-0.071102746,-0.05663989,-0.009859066,-0.023924006,0.027332783,0.0063983034,-0.048062928,-0.056974247,0.043643937,0.13801952,-0.070609964 +1.1.1.93,"meso-tartrate and (R,R)-tartrate act as substrates. Requires Mn2+ and a monovalent cation.",384,1.0,-0.0094668735,-0.023717478,0.0023365698,0.044696543,0.09805083,-0.02955328,0.06644369,0.069798626,-0.009904497,0.036391873,-0.025062887,-0.063190855,0.026970394,0.064274,-0.026739594,0.03100947,-0.05393682,-0.008908118,0.061665505,0.10501531,0.092885286,-0.012275731,0.005819762,-0.08915763,0.024564596,0.121796325,-0.01098247,-0.030837176,0.088575274,-0.07781645,-0.06130383,0.034340348,0.040432055,-0.042203125,0.025628716,0.08419476,-0.0039405855,-0.04305264,-0.025148792,-0.04276524,-0.010712411,0.00012260249,0.12754725,-0.01530399,-0.029046623,-0.07024178,0.0817592,-0.05381949,-0.012941794,0.020172618,-0.03813817,-0.03346896,-0.03984188,0.08890431,0.010553931,-0.011518209,-0.09898982,0.05890217,-0.013775305,-0.07719936,0.0442046,0.0015558811,0.012963381,3.7662146e-06,0.0109670125,0.0070398687,-0.038990393,0.04325766,0.050843317,0.01658255,0.00041096925,0.004006053,-0.027790025,-0.032278243,0.06128859,0.07504905,0.07681875,0.03147726,-0.00960301,0.018956514,-0.096016735,0.017660642,0.03910114,-0.018105634,-0.019670736,0.11559463,0.034570426,-0.029882403,0.011472429,-0.016220346,-0.0054607457,0.07031803,-0.050766587,-0.012004304,-0.05555593,0.034293406,0.03775805,0.06332172,0.032143645,0.016266907,0.04033579,0.115184925,-0.14378978,-0.055899117,-0.039511606,-0.043960586,-0.008876275,0.025462478,-0.013982464,0.030755753,0.021811388,0.00922875,0.00061934476,0.054734096,-0.0023069757,0.0807152,0.017568752,-0.026179556,-0.011950122,0.019825269,-0.0034598904,0.0410247,-0.0075215474,-0.010893518,-0.054852538,-0.011869168,-0.02403421,-2.5571982e-34,0.04714298,0.055212513,0.013191436,0.011257751,-0.039327495,-0.033466995,-0.08392036,-0.007155089,-0.028532526,-0.024674695,-0.091012254,-0.04208096,0.038229275,0.011699314,-0.074916035,0.00366141,0.01335813,-0.058043115,0.108872004,-0.007618823,-0.027546015,0.114353806,-0.021064917,-0.0444864,-0.06356644,0.026710251,0.09498299,-0.040989563,0.06283752,-0.03704478,0.0766211,-0.04221889,-0.033201504,0.03432228,0.046532348,0.00052570633,-0.0978527,0.014146773,0.0277521,-0.010574397,0.011951039,0.037232872,-0.051173225,0.0036048251,0.08474296,-0.082808845,0.05320425,0.029965406,-0.037098244,0.02027096,0.014185521,0.053853776,0.03442359,-0.060137227,-0.0730417,0.022763096,0.016170608,0.0007025298,0.011192746,0.06811116,-0.044440124,0.01865646,0.044083055,0.0862239,0.00073910353,0.016326219,-0.09360231,-0.030374652,0.034173094,0.07162449,0.023518354,-0.11748458,0.09803985,0.039195105,0.0066435155,0.01510859,-0.028955298,-0.077217616,0.08915258,0.018103817,-0.001135041,0.021098776,-0.043168556,-0.08854018,-0.08198785,-0.023923237,0.015091002,-0.11630846,0.019871403,0.096085764,-0.032007486,-0.022450477,-0.049850848,-0.06763164,-0.015612068,-2.0262196e-33,0.04819648,-0.028858582,-0.047862206,-0.056186818,-0.13036038,-0.03327093,0.0661118,-0.12565641,0.045403935,-0.0038214491,0.061242238,-0.0035581174,0.022355627,0.028823385,-0.07024894,0.018266043,0.02152963,0.029236069,0.084419236,0.0042365855,-0.044579577,0.10427129,-0.04771742,0.10008335,-0.05676722,0.006244048,0.053977314,-0.01654088,0.049430978,-0.013254518,0.09007797,-0.042802393,-0.0026219185,-0.08018325,-0.047124375,0.06332847,-0.008668031,-0.057593882,-0.022256585,-0.0033478397,0.012184463,-0.01621115,0.01589434,-0.006719307,-0.020935604,-0.035392296,-0.08692734,0.023743507,-0.041869603,-0.030381612,-0.06379619,-0.08092461,-0.05701853,-0.10300356,0.069198206,0.06517124,-0.024322687,0.016223677,0.051036652,-0.00029306076,0.03338082,-0.03704186,0.006004401,-0.11349949,0.014773205,0.05072707,0.02950488,-0.07164246,-0.0112422975,0.032397877,0.080027826,0.060872346,0.054442577,-0.032610677,-0.010667883,-0.08775552,0.00034406624,-0.032257445,-0.004348782,-0.15191065,0.0026892193,0.02575518,-0.020757323,-0.06410722,-0.05356005,-0.04852344,0.007846,0.07664241,0.02299713,0.026981046,0.031755097,-0.03058437,-0.023929428,0.030832443,0.05454369,-2.8160276e-08,0.031817082,-0.05059212,0.01567668,0.0052672783,-0.1000159,0.053636406,0.039016653,-0.04850192,-0.0037292475,0.023482867,0.007051052,-0.045486704,0.04932468,-0.068455644,0.07675959,0.057781324,0.0043859943,-0.0042893738,-0.076081805,-0.015088434,-0.04358326,-0.011851329,-0.052754678,0.026802318,0.049354944,-0.048089232,0.036471564,0.027349308,-0.06882143,-0.056422763,0.018213416,0.057903547,0.033054333,-0.073227964,0.010439284,0.037882958,0.06535302,-0.008487593,-0.0016890428,0.005193666,-0.033246864,0.05442015,-0.01681909,0.013817663,-0.047583334,-0.0017496527,-0.10599685,0.07014698,-0.03527837,-0.003021913,0.041465502,-0.0724388,0.008777232,-0.04743789,-0.018811801,0.039212707,-0.052944697,0.029675525,0.00036173916,-0.019116068,0.008090023,-0.004957274,0.058134545,-0.1058865 +1.1.1.94,The enzyme from Escherichia coli shows specificity for the B side of NADPH.,384,1.0,-0.06486742,-0.039075468,-0.07269244,-0.0094026355,-0.008748608,0.09164887,-0.029351247,0.07465542,0.062151577,-0.012146689,-0.0057765474,-0.027555931,-0.045776747,0.100403324,0.0006471568,0.011242707,-0.07211104,-0.008136307,-0.031236071,-0.041807868,0.035979606,0.03800274,0.03235791,-0.02305214,0.04486549,0.01188885,0.029231071,0.016719148,0.012887112,-0.109260134,-0.09892009,0.016385261,-0.00978746,-0.036874283,0.123895034,0.026361588,-0.019091276,-0.023864439,0.058806397,-0.049764298,0.016232975,0.0074345637,-0.05379741,0.024313308,-0.0045798873,0.022277959,-0.011684649,0.12324899,0.067821085,0.013389127,-0.0528703,-0.065065615,-0.033312313,0.06967439,0.063252844,0.020049369,-0.01458283,-0.023914162,0.02449055,-0.037494525,-0.016003137,-0.06291081,0.0304442,0.007717105,0.058735922,-0.047779363,0.102579415,-0.04223131,-0.03837303,-0.07966697,-0.07182507,-0.007814178,0.0032475756,0.0011164049,0.013513134,0.052262567,-0.03042121,-0.024394192,-0.02410196,0.029716035,0.017032683,0.01764902,-0.015309653,0.15054297,0.037360292,0.01866478,0.023098152,0.008814664,0.005395641,0.027567644,-0.00075153343,-0.071311004,0.0075788326,-0.024037637,-0.079328135,-0.012094603,0.05030289,0.008821732,0.017942179,-0.03144152,-0.028431037,0.044705275,0.056082796,-0.017738026,-0.049881402,-0.027108489,0.0015483581,0.08341831,0.04626722,-0.047643937,0.04828082,0.017937671,0.061231613,-0.022369295,-0.050344866,0.026471777,0.019014215,-0.0018180026,-0.09959502,-0.034733888,0.005421143,-0.016878042,0.019854836,-0.005384525,-0.03335926,0.0065459837,-0.12616979,6.866577e-36,0.11108559,0.050249986,0.04066859,-0.01835448,0.031916894,-0.0025728631,-0.074228875,0.050775833,-0.07147209,-0.01908948,-0.026629737,-0.07798066,0.017118553,-0.052526217,0.033942927,0.057212368,-0.046948027,-0.057924107,-0.08002262,-0.032977037,0.04442688,0.057405714,-0.0560813,-0.03734497,-0.013507127,-0.04369988,-0.008542999,0.049479082,-0.001989798,-0.00041793697,0.03132287,-0.05324777,-0.08857361,0.010004337,0.09688003,-0.050956234,-0.041281395,-0.04454495,-0.031066513,0.054973066,-0.044878844,0.05872229,-0.031572137,-0.059261825,0.0907441,-0.11431706,-0.034997053,0.04711133,0.051669728,0.05808393,0.015382534,-0.025171045,0.12304756,-0.06507511,0.0010966812,0.065787435,-0.0072181313,-0.009598436,-0.03982584,0.07389193,0.06706796,0.047043625,-0.030330863,0.022152942,-0.1101045,0.0042447015,-0.10045082,-0.053123727,0.021418853,0.103128925,-0.019269636,-0.008661824,0.063782535,0.008716337,-0.02812471,-0.052138742,-0.081041306,0.02324171,0.05986154,-0.03062297,0.008937863,-0.062301237,-0.041414805,-0.01249013,-0.104808636,0.035464972,0.051376414,-0.07493629,-0.03316977,0.012209351,0.10065396,-0.038217735,-0.020620089,-0.0034979342,-0.021175455,-1.3962256e-33,0.047946557,-0.05597561,0.056592055,-0.13438489,-0.1061843,0.048921656,0.10489708,-0.06747404,0.027576465,0.0059191585,0.054273196,0.08037143,-0.00071134465,0.008867117,0.028566424,0.011039493,0.007644726,0.04297466,0.02251643,0.011498606,-0.02693042,0.09103342,0.01874613,-0.05259452,0.05601558,-0.0020290753,-0.012907751,0.091531925,0.010969198,0.028561488,-0.04726152,-0.010006715,-0.073557705,-0.08477718,-0.021069719,0.014338145,-0.06467366,-0.03291188,0.07269052,0.002327231,-0.022199435,-0.0012468618,-0.049320642,0.016666789,0.07578008,0.037809234,-0.025675992,0.017514292,0.09557158,-0.078573175,0.014456137,0.03201435,0.0027840747,0.0044150804,0.019074986,-0.006254377,-0.05731654,0.016293418,0.019949637,0.027881665,-0.0012884202,-0.04258045,0.06277238,0.041180663,0.02968394,0.036970455,0.0015283084,-0.024152404,0.11122115,-0.083002865,0.053398013,0.060142685,0.022022178,0.05435888,-0.025032397,-0.05686612,-0.105269425,-0.03918624,-0.009171369,-0.04936047,-0.04482052,0.034569487,-0.052263875,-0.039412588,-0.012532509,-0.045929894,0.014972796,0.06985811,0.019088766,-0.0014470405,-0.018502658,0.058910124,-0.04789106,0.053274088,0.047200937,-2.2798925e-08,0.065854914,-0.058820855,0.021613007,-0.072597064,0.022088572,0.031465344,0.009373986,-0.084503576,0.06013712,0.017519739,-0.048246935,0.13337743,0.0031399755,0.028875548,0.02142568,0.031527072,-0.08445616,-0.050136726,-0.02313914,-0.020646594,-0.018714815,-0.02433439,-0.018171718,0.044505015,0.01223497,-0.037749767,-0.045128915,0.001639519,0.025421098,-0.04282663,0.019538878,-0.04353959,0.06691995,-0.059544034,-0.005972286,0.059266705,-0.062495664,0.057482444,-0.019568285,0.092734784,0.07877507,-0.10207954,-0.06101894,0.042179357,0.05040535,0.033827633,-0.00050913193,-0.0029407418,-0.057057146,0.0007273864,0.10884079,-0.032457985,0.030846061,0.046578646,-0.11323104,0.015221095,-0.00455116,-0.07795399,0.02200795,-0.036231894,0.0484683,0.093197584,0.096879,-0.015345211 +1.1.1.95,"This enzyme catalyses the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis. The reaction occurs predominantly in the direction of reduction. The enzyme from the bacterium Escherichia coli also catalyses the activity of EC 1.1.1.399, 2-oxoglutarate reductase [6].",384,1.0,-0.00045146744,0.018159335,-0.08883673,-0.0014290599,0.05975145,0.06560171,-0.046464078,0.01850741,0.061308578,0.005110408,-0.013358581,0.03416253,-0.05600056,0.0052063097,-0.010529244,0.008773836,-0.12458728,0.018051134,-0.011647686,-0.045426417,0.1691655,-0.020844243,-0.0031733261,0.01262171,-0.022045251,-0.042837825,0.05345061,-0.06486414,-0.085878864,-0.063935146,-0.0027802,-0.10654539,0.04402289,-0.039552253,0.05477781,0.039858222,0.0032007364,-0.08943326,0.021897877,0.049928006,0.0016229175,-0.007364642,-0.05619836,-0.032006353,-0.013683236,-0.04319334,-0.0005727973,0.010038099,0.015793655,-0.03768303,-0.062386155,-0.01547194,-0.054231953,-0.010668047,0.053561594,0.012300806,-0.083796084,-0.013195663,0.016485136,-0.036448546,0.020290831,0.0136895,-0.020646103,-0.028748885,0.053478144,-0.10172234,0.07062187,-0.10138801,-0.0059741386,-0.028468205,-0.06388403,-0.09231408,0.0025075017,0.006659554,0.024467655,-0.023924189,-0.02724834,0.023047576,0.047484946,0.009041608,0.05301361,-0.04328766,-0.028456198,0.07282512,0.01584413,0.0083905235,0.004234276,-0.017714767,0.09910494,0.054007653,0.014124184,-0.07918238,0.026574975,-0.02124609,0.0019425066,0.0152070625,-0.040189784,0.076058134,0.035735857,-0.024292622,-0.004741172,0.12388915,-0.028276857,-0.058922105,-0.03258565,0.0054778033,0.02246987,0.14577475,-0.020238314,0.008884539,0.007973747,-0.041331828,0.037840627,0.06343152,-0.024350548,0.14742763,0.0010058321,-0.078796685,-0.088206716,-0.015769262,0.06491016,-0.0036200827,0.04147775,0.08696421,-0.03810307,0.06116515,-0.13907662,2.154505e-33,0.07381519,0.043090675,0.040028527,-0.10398393,0.026883818,0.010165741,-0.081504054,0.027888916,-0.015604187,-0.02386394,-0.10006446,-0.06074579,0.0590647,0.0029066738,-0.055091016,-0.11607067,-0.012793557,0.033962104,0.06387828,0.016374482,-0.019545054,0.020309431,0.031747177,0.018292697,-0.023548316,0.006864386,-0.092005454,0.026668143,0.008708913,0.0023296815,0.04279785,-0.0801227,-0.07515593,0.012820057,0.014993227,-0.051776044,-0.035656065,-0.0060728476,0.0058692535,0.063896894,-0.05029493,0.034333408,-0.017229881,-0.0034775396,0.040210936,-0.04778812,-0.083336204,0.10378216,0.07741808,0.1113972,-0.004058235,-0.020515045,0.07780174,-0.012266586,-0.037485037,0.023972604,-0.020728515,-0.01718927,0.016270852,0.0798386,0.00461637,0.06338323,-0.019575775,0.019569121,0.0089873625,0.02417605,-0.017761357,0.004164695,-0.021301584,0.08971096,-0.07585611,0.015827572,0.059079412,-0.03009547,0.060411606,-0.04647679,-0.03927362,0.04044608,-0.031507894,-0.02442369,-0.008991383,0.0053097126,-0.038796883,0.04448042,0.0017576964,0.027874399,-0.009580436,-0.014102005,-0.021138342,0.11494217,0.030604674,-0.088602215,-0.020823307,0.016269807,0.037229907,-2.2410679e-33,0.08543615,-0.097551614,0.0032721246,-0.117403194,-0.028158821,0.040313452,0.048348166,-0.009419219,0.045463398,0.024169086,0.041889373,-0.0016423956,0.05098588,-0.02693985,-0.007234201,-0.035256624,0.01919161,0.07666336,-0.0021140138,0.012673165,0.024197645,0.067969665,-0.007834122,0.033236858,0.072909705,-0.015444414,0.0032565247,0.122228734,0.032667287,-0.024100348,-0.01610181,-0.008860194,-0.035614833,-0.055308335,-0.05130668,0.07503585,-0.06375213,0.042776614,0.07245962,0.03543285,0.014506074,0.00045845786,-0.020760471,0.027053257,0.084195584,0.05299569,-0.058792714,0.07194389,-0.028606942,-0.06690569,0.00019183388,0.031047901,0.017228384,0.00539135,0.054738738,0.044972185,0.0021153344,0.005125113,-0.024012167,0.030403698,-0.01054652,-0.019979382,0.030237941,-0.0014699524,0.0853805,-0.04633802,-0.008082757,0.05236126,0.01693624,0.065310545,0.07414591,0.029690592,0.01610756,0.05812364,0.011912861,-0.099397734,-0.12264004,-0.03819172,0.019979654,-0.033330906,0.005596476,0.0107040955,0.034473408,-0.13823007,0.005685201,-0.03991896,0.03573568,0.08959333,0.0148015665,0.035758276,-0.044720244,-0.07694987,-0.028082253,0.054130122,0.0022861394,-3.402204e-08,0.015888186,-0.08757842,0.057926357,0.00077909953,0.06097579,0.05615458,0.037596006,0.0350369,-0.011260486,-0.09492599,0.014006385,0.09079169,0.082273975,-0.018329067,0.033458803,0.0006408049,-0.047249667,0.014708786,-0.013321094,-0.030950101,-0.032994833,-0.04297959,-0.11996268,0.029791959,0.05247437,-0.0659026,0.06172982,0.05658931,-0.060215954,-0.04217254,-0.0012609088,-0.00921241,0.020924293,-0.02590418,-0.067181945,-0.03591929,-0.04998573,5.5272976e-06,0.012239025,-0.013532177,-0.01873995,-0.041996025,-0.0389093,0.028985444,0.03210385,0.082855135,-0.009618009,-0.0144976955,-0.028879274,-0.027652556,0.030472293,-0.032099776,-0.005913355,-0.021898635,-0.08624999,-0.01304718,-0.020317476,-0.073606774,0.009409954,0.0054570483,0.034267552,0.047475465,0.18682414,-0.024171086 +1.3.98.4,"The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyses the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline.",384,1.0,-0.048402634,0.025065767,-0.18164559,-0.015557776,0.0144213475,0.011039113,-0.056869604,0.04399427,0.10171437,-0.019131938,-0.033530597,-0.06515914,0.03582161,0.077902615,-0.099052355,-0.0399281,-0.111506216,0.0140985735,0.041269407,-0.076726586,0.034934673,0.07944278,0.026696282,0.011827923,0.034733236,0.032098852,-0.02269223,0.0143049825,-0.041748796,0.0042437688,0.03900087,-0.007660738,0.05753664,-0.0771634,0.098483235,0.045480642,-0.08092043,0.014104292,0.11942567,-0.032593247,-0.053724628,-0.0049174954,-0.0063368445,0.028045034,-0.033366837,0.033771027,0.077867605,0.04076188,0.03516095,0.0131951235,0.011126293,-0.028847951,-0.11093352,0.08593023,0.024690751,0.068618536,0.010353194,-0.014308895,0.050295502,-0.04260985,0.08991623,-0.026408814,0.034170512,0.07063382,-0.06562178,-0.02633822,0.005901114,-0.08462948,0.0149676725,-0.021097638,-0.07455986,-0.03647944,1.8579753e-05,0.044221003,0.009031316,0.0036921296,0.03966257,-0.01880642,-0.07928435,0.0047923983,0.02317724,-0.07669295,-0.04562656,0.089281894,0.06093519,-0.065600656,0.022376053,-0.0072950716,0.09509888,0.02950164,0.039563775,0.0031484137,0.018596772,-0.058467377,-0.023719294,-0.026758168,-0.017608041,0.02120289,0.028287789,-0.02285483,-0.0795256,0.001434228,0.013273354,-0.033588346,-0.01252394,0.031745672,-0.0037639448,0.042080294,0.039260924,-0.032645587,-0.024347674,-0.0133035155,0.021620132,0.0033387362,-0.009678668,0.06076932,0.038199354,-0.05327054,-0.0165088,0.058073808,0.007015107,0.02442961,0.007852207,0.014515544,0.041135468,0.03832189,-0.05353181,5.306324e-33,-0.017845612,0.09680812,0.016299637,-0.06108415,0.061921824,-0.01626992,-0.003936484,-0.02012626,0.0038052485,-0.022647016,-0.09818221,-0.079415664,0.050487895,0.036250312,0.02316223,-0.010083752,0.008970839,0.036422063,-0.0010218099,0.04457207,-0.029060178,0.060448285,-0.02235061,0.011275014,0.053183515,0.07922788,-0.015299768,0.034023438,0.05659207,-0.0139330905,0.012079144,-0.08216756,-0.07358782,-0.0043953517,0.069603,0.00062700553,-0.07370574,-0.03014812,0.08057084,0.041029867,0.015263495,0.008744769,-0.009334002,-0.0053301267,0.018606532,-0.017247107,-0.031042812,0.09802708,0.03287907,0.07708343,0.06112104,-0.061750516,0.04915554,-0.0124665415,-0.058025602,0.06190175,-0.069191605,0.049007278,0.049035534,0.0036111465,-0.008993791,-0.011026799,-0.037565503,0.023546545,0.01419258,-0.009421753,-0.03618059,-0.041003592,-0.026815033,0.03816046,-0.10106425,0.043457344,0.0538988,0.0020384183,0.04813127,0.049023766,-0.041829456,-0.074944966,0.11538262,-0.05786025,-0.055461124,0.015984142,0.008117542,-0.05543356,-0.030821057,0.004712419,-0.049953427,-0.050409637,-0.01897671,0.09596896,-0.021349045,-0.08846218,-0.10461846,0.020091375,-0.011270941,-6.349558e-33,0.07565364,-0.073443055,0.0064198785,-0.058195386,-0.05157441,0.060500294,-0.075194314,-0.069517344,-0.002839503,-0.039769907,0.05905179,-0.061545968,-0.0034773904,-0.044476807,-0.027415477,-0.047925264,0.08198271,0.07034321,0.02564808,0.0010546943,0.07151394,0.006729268,-0.05366358,-0.08017506,-0.0022325749,0.01231454,-0.009526726,0.061406154,0.069357395,0.07163352,-0.036169887,-0.05385712,0.00812231,-0.0019428293,-0.044812266,0.18290181,-0.03825315,-0.022728851,0.11159801,0.026271807,0.08454952,0.012554598,-0.004056055,0.066556625,0.023030642,0.038768932,-0.074124366,0.06791975,-0.011532915,-0.091441795,0.046994522,0.025076523,0.039207436,0.00063920295,0.01655248,0.039143093,0.037771977,-0.06701183,-0.019976724,-0.08052755,-0.037824646,-0.045551553,0.028920222,0.02478901,0.018431712,0.019359807,-0.08254276,0.05932068,0.052016955,-0.0052246954,0.016512118,-0.021924539,-0.05879825,-0.031872675,-0.008642722,-0.06005667,-0.06582535,-0.07397993,0.04318792,-0.050019592,-0.010120189,0.035728194,0.047647487,-0.044640772,-0.03468859,-0.031844612,-0.001173689,0.037804995,0.034732793,0.039164543,-0.02547726,0.022431308,-0.006809179,0.030035472,0.0837398,-3.4098008e-08,0.04518952,-0.029833086,0.06853036,0.00381298,0.053904966,0.0026848868,-0.021966822,-0.012458228,0.0067387223,-0.04804649,-0.010021226,0.0020064402,0.016617639,-0.025587749,0.0012360277,0.08358779,-0.09266492,-0.08027859,0.009663487,-0.013182321,-0.08773195,0.03173871,-0.12532447,0.0050547775,0.013991095,-0.012870097,0.014591345,-0.030219419,-0.07127811,-0.023258753,0.032371577,0.024337297,-0.052557044,-0.033132322,-0.060402848,-0.06028563,-0.07744993,-0.058186185,0.033337533,-0.03552268,0.0013801422,0.07013315,-0.11546715,0.020970354,-0.042597238,0.013937806,-0.0041287635,-0.011733693,-0.11109629,-0.10614576,0.074895345,-0.01956606,-0.029453361,0.0010090086,-0.041016866,0.030783087,0.0059636193,-0.037423108,-0.060160074,-0.03223844,-0.036490057,0.040818106,0.1797944,-0.048414286 +1.1.1.96,Substrates contain an aromatic ring with a pyruvate side chain. The most active substrates are halogenated derivatives. Compounds with hydroxy or amino groups in the 3 or 5 position are inactive.,384,1.0,0.038328663,-0.096151546,-0.0357158,-0.03980586,0.0806413,0.07613946,0.025874287,0.031244932,0.042722516,-0.028342383,0.03306254,-0.028956747,-0.06334222,0.04849991,0.010660122,0.026425447,-0.008136913,-0.06329944,0.08341497,-0.030695818,0.037952013,0.03512254,0.028125258,0.006192396,-0.038255252,0.015850784,0.06904369,-0.021346021,0.056905206,-0.032225322,-0.038483556,0.07018109,0.016410097,-0.028883465,0.015646098,0.12061213,-0.12162263,-0.053855743,0.002885809,-0.008922617,0.103880525,-0.025445396,-0.03613831,-0.051714662,0.0068742274,-0.019451775,-0.0005309081,-0.042444006,-0.051933605,-0.046753574,0.041151375,-0.026620295,-0.03989538,0.08554431,-0.025905216,0.012884726,-0.02258469,0.0016600264,-0.064494215,-0.00016488887,-0.0070026745,-0.012197478,-0.039277483,-0.10141993,-0.06485745,0.01569189,0.038059834,-0.03761426,0.013814821,-0.016766407,-0.10070875,-0.08648227,-0.027612973,-0.0118934335,0.080448665,0.03191251,0.027519844,-0.09543477,-0.012371896,-0.097257964,-0.006832414,0.011735535,0.04055266,0.06452537,0.0281224,0.010317975,-0.0396942,-0.006864894,-0.03640405,0.031028394,-0.042630218,0.0270026,-0.034584656,-0.0047146413,-0.0491242,-0.01296881,0.031198004,0.02209885,0.055794813,0.026519528,0.07239722,0.029612876,-0.076887,-0.005511504,-0.102611974,0.013646325,0.020094953,0.03579569,0.0020153855,-0.037026834,-0.03773145,0.08672812,0.0033254074,-0.04054807,-0.07621842,-0.021754371,0.072241865,-0.044450782,-0.026675528,0.019991517,0.003685392,0.0434636,0.08148966,0.022154652,-0.10084151,-0.003350535,-0.06172321,2.320682e-33,0.022777203,-0.044950053,0.03289842,0.025291728,-0.06850634,0.012372174,-0.060936425,-0.026381612,0.042664316,-0.06767485,-0.0375741,0.048609164,-0.033185046,0.049841233,0.068984814,-0.1011209,-0.014275791,0.092688166,0.05837312,-0.01972675,-0.058831207,0.04001537,-0.025513744,0.0038933847,0.052851047,-0.017191702,-0.029375695,0.017990468,-0.07873297,-0.0016322414,-0.0021422468,-0.015843015,-0.008758707,-0.02769684,0.0007471396,0.09010765,-0.057422195,-0.014810791,0.0090517085,-0.005433186,-0.024244785,0.03524868,0.06551934,0.017514316,-0.042309444,0.015455571,-0.01483142,0.08399314,-0.017716447,0.016672708,0.02155471,-0.07642055,0.06251884,-0.11597688,0.004387748,0.060940303,-0.04711433,-0.019837588,0.059701547,0.056942444,0.009331629,0.07252649,-0.07231033,0.026541803,-0.024214935,0.025954343,-0.06664828,-0.07339271,-0.068281785,0.06379838,-0.013631752,0.042123914,0.08871501,0.038329147,0.06445769,-0.03250887,-0.15109296,-0.02472462,0.004236828,0.02261579,0.01953852,-0.03958292,-0.040838264,-0.030707173,-0.1271471,-0.01140191,0.010503648,-0.04081828,0.012550685,0.070079826,-0.0076401746,-0.022221774,0.06886492,0.012056706,-0.014499252,-3.7870262e-33,0.048218064,-0.08142964,-0.04038932,-0.06370275,-0.0324683,0.05584437,0.07379762,-0.082329735,-0.041942623,-0.024084566,0.0624212,0.061570417,-0.053832885,-0.015570416,-0.039712485,0.016712535,-0.010490943,0.06468396,0.044047955,-0.03184398,0.019698178,0.063329205,-0.03098551,0.08251625,-0.021569544,0.027403774,-0.03214484,0.069962576,0.06123391,0.04579672,-0.058545377,-0.015561448,0.055659983,0.0033154082,0.011172106,0.07865502,-0.0069802767,-0.007694644,-0.053454045,-0.025261994,0.041995827,0.09365293,0.002176343,0.07890133,0.017340742,0.060986307,-0.048989672,-0.007542358,0.012113615,-0.007420725,-0.0046508913,-0.016616587,-0.04705529,-0.089481845,0.015961148,0.058750756,-0.035558358,-0.01995151,0.05389775,-0.054714687,-0.017529711,-9.8915494e-05,0.010390234,-0.055660587,0.004403016,0.031407982,0.05287844,-0.026973074,0.019065311,0.010926373,0.10844932,0.079327986,-0.008191041,-0.03124632,-0.0644923,0.013453061,-0.018613713,-0.0010238976,-0.024034524,-0.0042886203,0.06544939,-0.008369963,0.0016543237,-0.054835096,-0.037198327,-0.10775646,-0.007957116,-0.0036803458,-0.010587951,-0.0030596617,0.029829372,-0.021002818,-0.032087985,0.073042765,0.058991477,-3.6359054e-08,0.07511067,-0.07773348,0.045054417,-0.046972524,-0.06773243,-0.022732355,0.10572085,-0.0064598736,0.07764591,-0.08142267,-0.009804853,0.04459581,0.040710907,-0.0021370943,0.11111378,0.08185702,-0.06485659,0.095143095,-0.050465044,-0.024468362,-0.11767999,0.045982525,-0.04322823,-0.021842254,-0.001996194,-0.08054637,0.0671577,0.051496517,0.05356594,-0.026101813,0.078077614,0.030447887,-0.0068646027,-0.012803836,0.051938508,0.032803614,-0.062351372,-0.04485018,0.009456329,0.09687174,-0.07473733,-0.10590791,-0.07207256,0.005289085,0.06295313,0.056948073,-0.054262925,0.086418636,0.0040211156,0.046442598,0.012279167,-0.021792488,-0.0108575225,-0.023517204,-0.094786465,-0.0028736137,0.011232285,-0.04956312,0.0143587105,-0.112790555,0.01655328,0.07373296,0.1624688,0.010195816 +1.1.1.100,Exhibits a marked preference for acyl-carrier-protein derivatives over CoA derivatives as substrates.,384,1.0,-0.086325,-0.08182124,-0.007117449,0.030538011,0.034338072,0.016636511,-0.026463252,0.1179934,0.03459719,-0.022437181,0.08819101,-0.038922098,-0.059722003,0.094808236,0.053988572,-0.0115023535,0.012873521,-0.015966212,0.03341395,-0.010106368,-0.07159833,0.0047051455,0.0057838475,0.013954364,0.028477669,-0.05619477,-0.008303716,-0.009301978,0.034140136,-0.07075055,0.0052057807,0.00935465,-0.015997913,-0.03365852,0.008864589,-0.006329027,-0.035520818,-0.08937405,0.051099546,-0.012078726,0.08298452,-0.0330236,-0.01012121,0.045053378,-0.062275853,-0.07757901,0.0030548018,0.017875526,-9.216555e-05,0.050625827,0.06279351,0.0074631665,-0.09153359,0.04057357,-0.023275737,0.04233118,-0.09544783,-0.0026679875,-0.01258197,0.013977692,-0.058530368,-0.012509775,-0.023783859,0.03038899,-0.037993867,-0.050559077,0.06278477,0.026647167,0.0494392,0.046833064,-0.007515023,-0.02219878,-0.016240079,0.026242906,0.071402356,0.036611307,0.031017048,-0.048051614,0.045250554,-0.0055176015,-0.022717325,0.030584082,0.07833671,0.03601921,0.01779641,-0.02586088,-0.004949985,-0.024130238,-0.080087885,-0.055154864,0.057743315,-0.048567776,0.026252797,0.02150902,-0.13931596,0.09292765,0.032701608,-0.006695123,-0.035140704,-0.00017426097,-0.027727285,0.07031773,-0.02187351,-0.010585475,-0.04597499,-0.0479853,-0.015460347,0.0349901,-0.025735123,-0.023414172,-0.028711185,0.022381857,0.027229799,-0.053563092,-0.058094192,0.033001084,-0.06849545,-0.022455238,0.06434836,-0.034897704,-0.030725883,0.001824498,0.0056886175,0.093738295,0.0042956094,-0.0024167926,-0.01309135,-3.9209294e-33,0.015036266,0.027084908,-0.021661192,0.031114241,0.0108457785,-0.08728101,-0.06550177,0.054310676,-0.043439306,0.037915424,-0.009067693,-0.0016429632,0.0064630844,0.059718642,0.07378964,-0.054733593,-0.027864764,0.023571862,0.083897434,0.06913481,-0.022039486,0.06448904,0.075614795,0.022550307,0.061920855,-0.07403395,-0.05674333,0.079861745,-0.0090512335,0.03121344,-0.06449802,-0.004816609,0.005255187,-0.021876762,0.026119491,-0.01757426,-0.10048214,-0.06880946,-0.032747593,0.058163505,0.068813816,0.008845295,-0.09826715,-0.029725472,0.04110102,0.010008881,-0.008477019,0.02191162,-0.086828955,-0.0027488323,0.028432135,0.015864369,0.05412277,-0.018396776,-0.019535193,0.008007851,-0.096854016,-0.035128705,0.009375331,-0.034378387,-0.0091585945,0.05160749,-0.0095125465,-0.0036965222,-0.029886147,0.010262999,-0.06304603,-0.03285103,-0.07170154,0.061302893,0.017455682,0.010394401,-0.012164989,-0.040090643,0.07971642,-0.010496226,-0.07293738,0.09837796,0.124178566,0.023545336,0.055013064,-0.020637725,0.020327158,0.00955733,-0.040421583,-0.105041824,0.013387423,-0.020694766,0.044895295,-0.016203275,0.05920419,0.010811743,0.02943501,-0.0011991195,-0.01808394,8.535304e-34,0.08131727,-0.10934668,-0.030277517,-0.09699431,-0.13213018,0.018947942,0.053273667,-0.02812805,0.06922244,-0.019236133,0.10112532,0.081706546,-0.113902755,-0.082286745,0.017524842,0.014004258,-0.031075757,-0.026977835,0.029145118,0.0033904703,-0.080373764,0.0025775153,-0.011478888,0.044117633,0.023322323,-0.0005229578,-0.066736214,0.052150365,0.04665978,0.06514179,-0.032036774,0.004897033,0.020975567,-0.016203906,-0.022358166,0.080679804,-0.006384474,0.058714546,-0.0011585448,0.037633054,-0.011858876,0.035761323,0.040921036,-0.0011704087,0.0694393,-0.006110791,-0.0218373,-0.05436773,0.005912096,-0.0883254,0.027184643,-0.02632552,0.0073483945,-0.06864195,-0.07187417,0.11035258,0.014053231,-0.045730487,0.06508672,-0.09650165,-0.03286442,0.00039443083,0.004043713,-0.040061045,-0.0639587,0.07495155,-0.05098164,-0.015847035,0.024893736,-0.04319202,0.018484583,0.013766464,0.026204726,0.001246624,0.002144197,-0.03368952,-0.013349594,-0.0071398905,-0.07213445,0.05403041,-0.06295017,-0.023722956,-0.059085086,0.006691308,-0.05796234,0.011566003,-0.036823694,-0.009390549,0.05058985,-0.010679264,0.0101060225,-0.040423542,0.0113939345,0.11822769,0.07122733,-2.1721307e-08,0.023247773,-0.04426388,-0.015631188,-0.0284932,0.026444104,0.06127838,-0.054153677,-0.10003593,0.0040661544,0.056229867,-0.034487545,0.12781566,-0.015738856,0.040683057,0.030383691,0.039928727,-0.051359992,-0.01592783,-0.03219128,-0.015315353,-0.07253453,0.06939833,0.07472279,0.041228026,0.005961551,-0.009001023,0.031784974,-0.066451855,0.046867017,-0.010234019,0.068921,0.018126115,-0.028339494,0.06380404,0.08569426,-0.008410321,0.08481308,-0.0850626,-0.025082173,0.14080983,0.02609361,-0.0028285596,-0.02529988,0.033624046,0.11341764,-0.023953026,0.026448058,0.09067445,-0.05971934,0.03303469,0.025207533,0.020360775,-0.13249573,-0.020680169,0.0005642865,-0.09308664,-0.10569657,-0.0876742,-0.033667743,-0.07361133,-0.027987141,0.007190017,0.18926094,-0.053224154 +1.1.1.101,Also acts on alkylglycerone 3-phosphate and alkylglycerol 3-phosphate.,384,1.0,-0.049795825,-0.07147949,-0.04465825,-0.019494181,-0.0044291206,-0.011115626,0.005521539,-0.020476393,0.049128056,0.009272048,0.056241896,0.033927083,-0.061951093,0.03116946,0.01892484,0.054719802,-0.058532495,0.021838836,0.0092648445,-0.063132286,0.12620354,0.032868408,0.07046703,0.0044551305,-0.0028480347,0.03146251,0.04611011,0.034122396,0.016661342,-0.021407282,-0.011763245,-0.06770659,0.002006358,-0.061441857,-0.014954902,0.07721042,-0.0865558,0.0066158315,-0.014755496,0.09019875,0.11565575,-0.09560366,-0.021668574,0.00021872793,0.034586307,-0.0049356306,-0.06636983,0.015803728,0.02486241,0.06647073,-0.075229876,-0.06547451,-0.02974745,0.021882143,0.009966211,-0.033560976,-0.08602259,0.09002197,-0.037474316,-0.023145942,-0.03726902,-0.029952602,0.02354378,0.022376537,0.0015781664,-0.046701986,-0.023387942,-0.056199525,-0.0015860393,0.011207066,-0.0086033875,-0.050713804,0.06428521,0.018515784,-0.017109137,0.023670133,-0.03273056,-0.0778783,-0.06714081,-0.020473197,0.0459347,-0.0014414431,0.020907337,0.10958532,0.010416201,0.005917094,-0.0257529,-0.045740567,-0.084530786,0.057497267,0.005080962,-0.043003656,-0.025508996,0.027878633,-0.023757001,-0.0012943591,-0.020519406,-0.036656793,-0.024430452,-0.00074654154,-0.020373413,0.016698059,-0.019459862,-0.072988614,0.0014411996,0.06510721,-0.06046585,-0.013656409,-0.03022929,0.03161772,0.005477263,0.006987458,0.04466155,-0.006875421,-0.073383845,0.09972795,-0.007742442,-0.0189458,-0.06041358,-0.017396234,-0.02547945,-0.09399019,0.028878413,-0.020056086,-0.06120594,0.07693114,-0.009519596,1.4698637e-33,0.030480519,0.011202033,-0.028818766,0.029048953,0.01715494,-0.0070454543,-0.044339713,-0.021838658,-0.06095644,-0.023202937,0.029503493,-0.02401463,0.077042766,0.007906406,-0.03554883,-0.01684365,-0.031785183,0.063783094,0.099322535,-0.0802919,0.028675128,0.042411614,-0.0646137,-0.015105687,-0.058046713,0.039960343,-0.0066868714,0.013525191,-0.020418396,-0.041038476,0.03879851,0.016848786,-0.050059978,-0.05170798,0.05754342,0.039697073,-0.026822418,-0.08021084,-0.0079755895,0.0045782826,0.016381046,-0.049020085,0.0042688763,-0.0008672192,0.025149377,-0.0055761714,-0.101797454,0.10426057,0.11382995,0.007416913,0.07477609,-0.05364303,0.11458959,0.043711282,-0.044270154,0.0166474,-0.062183827,-0.065708555,0.02689847,0.013098168,-0.008315879,0.017784903,-0.0156841,-0.013036568,0.002057581,-0.031004602,-0.09117815,-0.03891316,-0.06810674,0.010636831,0.021910844,-0.028702358,0.0986035,0.024369389,-0.058984164,0.043582313,0.00058016274,0.020919325,-0.027734598,0.0420746,0.042371992,-0.056610353,0.058265895,-0.026905127,-0.07341007,0.04089085,-0.037493654,-0.120476514,0.023152182,-0.033261705,0.030610947,-0.04578676,-0.09229601,0.017229607,-0.007237677,-3.5428867e-33,0.036404267,-0.061810464,0.07461446,-0.042985138,-0.00017834941,0.0042713243,0.041548032,-0.008362121,0.06831184,0.037408445,0.07112941,-0.025784485,-0.016631024,-0.06505703,0.014049656,0.07279694,0.0015319815,0.01137924,-0.03555911,-0.034631126,0.037779152,0.10708207,-0.010064607,0.18199019,-0.0043005645,0.026420312,-0.05951406,-0.025761068,-0.008967959,0.120667815,0.0458873,-0.049320195,-0.09250103,-0.05085232,-0.020145185,0.015150646,-0.028503517,0.007181878,-0.05610571,-0.017735222,0.0580364,-0.011705042,0.10863351,0.028326271,0.0681591,0.0668676,0.012132311,0.01603468,-0.07135257,-0.037089318,-0.0339253,0.032001097,-0.020873556,0.07384629,0.08973702,0.12587404,0.009087034,-0.070430145,0.015774323,-0.046844423,-0.03229243,-0.010329536,0.032464135,-0.06004931,0.058737837,0.0603504,0.04605882,-0.015670639,0.10986201,0.03948608,0.07651835,0.052266687,-0.026144851,0.032381184,-0.07608603,0.010481248,-0.05229337,-0.042368185,-0.080686405,-0.03963368,0.03939229,0.0035291705,0.021959873,-0.042053238,-0.077190205,0.011477871,-0.002775924,0.06891649,-0.06792244,0.03432686,-0.040010612,-0.0058722496,-0.06340662,-0.0075704083,-0.03330193,-2.5271971e-08,0.015504948,-0.02375907,0.08367285,-0.07548243,-0.08796922,-0.045693375,0.11248582,0.1312883,0.053513065,-0.07668298,-0.04575664,0.07194496,0.07593223,-0.034351353,0.1211473,-0.008733414,0.0035935114,0.05948477,-0.024191316,-0.12831354,-0.053659573,-0.023751184,0.016330928,0.07381743,-0.020997766,-0.018860733,0.017716998,0.063230835,0.041547626,0.033864502,0.035989467,-0.04101476,0.0024254348,-0.017374488,0.035660245,0.0865159,-0.016880125,-0.026195131,-0.05490581,0.0602483,-0.04827769,-0.033818632,-0.016194332,0.06157926,-0.038917214,-0.021372182,-0.012418062,0.017019209,-0.013821686,-0.02303144,0.02348739,0.019621737,-0.05667493,-0.020853419,-0.12104949,-0.0508375,-0.050800428,-0.022788784,0.04644848,-0.015906747,-0.00055140705,0.005811133,0.16314699,0.014840921 +1.1.1.103,"This enzyme acts in concert with EC 2.3.1.29, glycine C-acetyltransferase, in the degradation of threonine to glycine. This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex [2]. In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.",384,0.99999994,-0.025007803,-0.032087564,-0.08557788,-0.04635187,0.058420066,0.03782619,-0.08468736,0.051476747,-0.011897175,0.022070218,-0.013424722,0.015055216,-0.014793899,-0.014023798,-0.02720459,0.045778465,-0.057449546,0.0214919,-0.010588961,-0.04670306,0.0074635283,0.02476319,-0.09252086,-0.073214896,0.06355573,-0.00075030903,0.03228379,-0.035085686,-0.026638765,-0.07264923,-0.035911433,-0.11648408,-0.014532895,-0.00047171963,0.04460467,0.088092804,-0.098111235,-0.07161252,0.1027214,-0.006796883,0.047498863,0.026955875,-0.054906953,-0.094477765,0.026856085,0.008380592,0.016801381,-0.007618639,0.015578471,0.030553918,-0.0017700681,0.025302304,-0.021719657,0.052374955,-0.07389631,-0.02251962,-0.043394227,-0.0136150615,-0.022644592,0.004935749,0.0007241314,-0.011065511,0.034542583,-0.05553623,0.06762593,-0.071367696,0.062960394,-0.040687207,0.02092402,-0.009951856,-0.061701734,-0.06296213,-0.010438448,0.042750437,-0.012925122,-0.049289297,-0.07218377,0.02031006,0.027370946,-0.036865734,0.08749808,-0.011752452,0.023405502,0.039497726,-0.011258699,0.021197695,-0.0359694,0.0020193863,0.038831815,0.043318003,0.020598553,0.027772095,0.032697987,-0.013572598,0.0040377006,0.00018995344,0.049126025,0.05623502,-0.016571222,-0.0050138975,-0.0051608137,0.0804502,-0.045467798,-0.06302059,-0.018770276,0.033914912,0.021606758,0.06513405,0.015569728,0.036260393,-0.031834744,-0.038056523,0.012549547,-0.03257949,-0.006302967,0.15167153,0.030414812,-0.018994194,-0.013853193,-0.04323952,0.03680066,0.024873631,0.10132561,0.047221046,-0.032461606,0.051979344,-0.032823533,2.058331e-33,0.052706636,0.062498834,0.004960288,0.0010559119,0.056110952,-0.008638769,-0.09835658,0.04090474,0.05060498,-0.06952672,-0.06386046,-0.10343308,0.015408844,-0.042552553,-0.032597043,-0.0118912645,-0.061030686,-0.006082914,0.026837295,-0.04740898,0.006778119,-0.0072918385,-0.041723907,0.033469815,-0.02460618,0.021976484,0.071991585,0.044466533,0.030214349,0.0019438149,-0.026485162,-0.07431108,-0.102949046,-0.024098942,0.048278946,-0.04359003,-0.054072585,-0.02977285,0.07271669,0.07575223,0.035640743,0.0043905503,0.0028188687,-0.06692842,0.053203426,-0.045792777,0.025319174,0.10862717,-0.017168911,-0.027301403,0.044517636,-0.109410234,0.06880913,-0.02839799,-0.037644893,0.027256984,-0.0022052538,-0.024493156,0.08101467,0.07997404,0.01637007,0.03751975,0.03154233,0.0028856734,-0.0096331695,0.027836889,-0.15016222,-0.0052660243,0.002078305,0.039242536,-0.0028493525,-0.08341537,0.1289437,0.02335906,0.033550534,-0.058000427,-0.08187414,0.03967004,0.012215088,-0.048545267,0.0072047794,0.027451025,-0.017661897,-0.0119028,0.028211819,-0.008313694,0.055904165,-0.12443885,-0.028600441,0.06838305,0.07144717,0.0068061166,-0.06271799,0.00313104,0.0034165597,-2.7014006e-33,0.09393251,-0.07716637,0.0020952262,-0.0022510327,-0.048624787,-0.020037748,-0.064707376,0.04025469,0.03260414,0.009523564,0.06789595,-0.03978904,0.028381625,-0.06339782,0.09026523,-0.044630703,0.030020444,0.053404197,-0.03588249,-0.040295664,0.03737981,-0.040493883,-0.048877966,-0.02520211,0.0015140575,0.022881404,-0.03896545,0.088262536,0.1340493,0.07950142,-0.06365953,0.037299722,-0.052255355,0.013925805,-0.03152397,0.061124355,-0.0038381612,0.0024395285,0.003897292,-0.019522578,0.008173556,0.01583112,0.0013668125,0.06883226,0.07831132,0.05123451,-0.03244983,-0.0024598315,0.0044871443,-0.08565608,0.05628912,-0.04670473,-0.027583834,0.021278117,-0.0184791,0.11795147,0.014317738,0.027827483,-0.0020497886,0.006679118,-0.04500811,-0.06938104,0.037589148,-0.004382361,0.09517244,0.005864524,-0.012878452,0.11031762,0.07090525,0.016046803,0.052042693,-0.0059094373,0.030594803,-0.0043649347,0.017970255,-0.023153385,-0.07680275,0.0109395925,-0.00039664467,-0.092468925,-0.03581543,-0.02661591,-0.0066204765,-0.0728651,-0.007322902,-0.10762307,0.0015934812,0.16450958,-0.034173347,0.055649146,-0.041414965,-0.05940185,-0.09056879,0.08161997,0.0016818746,-3.8773827e-08,0.0325146,-0.023794234,0.03608588,0.014143453,0.028299864,0.05166082,-0.02007854,0.060628835,0.048808265,-0.057762686,-0.068314575,0.05941389,-0.021063346,-0.0350193,-0.008303237,0.10226407,-0.056439266,0.07948693,-0.012344406,0.053087402,-0.06106349,-0.028293448,-0.07473334,0.0049282894,-0.031900566,0.016512554,0.03891491,0.04239609,-0.038314566,-0.05457898,-0.021745766,0.03829061,0.06899029,-0.057367355,-0.08488993,-0.04879271,-0.007947439,-0.06328777,0.011864387,-0.05452014,-0.0026234065,0.06043126,-0.121985905,0.06466211,0.051610973,-0.0023929449,0.02921792,0.027409133,-0.1018736,-0.051574104,0.022799818,0.01837629,0.009217366,-0.0625713,-0.053633075,0.00044962845,-0.073883295,-0.04042729,0.020950003,-0.019996693,-0.00029170327,0.044336095,0.17975642,-0.0046202145 +1.1.1.104,"The enzyme, isolated from animals, is specific for 4-oxo-L-proline and cis-4-hydroxy-L-proline. It has no activity with trans-4-hydroxy-L-proline.",384,1.0,-0.009815152,-0.09368613,-0.04309944,-0.03314311,0.042708784,0.061304174,-0.06626033,0.057376165,-0.005477762,-0.017944982,0.04527701,0.0054368833,-0.02028886,0.07510123,-0.017767355,0.117467314,-0.055740364,-0.070098154,-0.010083855,-0.013090563,0.01133966,-0.0271424,0.0042579663,0.019108856,0.0018360866,-0.06868535,0.054689478,0.010371424,-0.012298983,-0.037743144,-0.032706644,-0.049038477,0.011179547,-0.034662183,0.061157014,-0.010366164,-0.022761406,-0.040963,0.06256469,0.063621655,0.072477356,-0.04363979,-0.04113222,-0.04936761,0.0067933174,-0.031313453,-0.03950869,-0.060874682,0.0425043,0.019888187,-0.01019668,-0.07481378,-0.05621006,0.07810244,-0.11614686,-0.023843097,-0.030189767,0.016041808,-0.025440149,0.0836206,0.030203206,0.030189253,0.025953626,0.019929787,0.033504874,0.014845674,-0.035670344,0.017742999,0.0028169216,-0.06511239,-0.016319849,-0.108812764,0.046526067,0.06497616,0.0007089064,-0.04161731,0.0024773849,-0.024198959,0.0497453,-0.06501338,0.010866841,0.023749491,-0.020225167,0.033453528,0.034040272,0.021958586,0.014984868,0.017058842,0.01980209,-0.005608289,0.011408226,-0.013909427,-0.054654572,-0.004142542,-0.0018580784,0.00869381,-0.02562494,-0.028537674,0.0034319372,-0.03109819,0.0036462818,0.02024651,-0.04876665,-0.12294035,-0.04342443,0.05944927,0.018437972,0.07097163,-0.0071783625,-0.011561215,0.009376915,-0.0328908,0.047230344,0.04584145,-0.0007507238,0.03708315,-0.017934268,-0.07988681,-0.025784563,-0.0067227837,0.009066509,0.0069401283,0.116022795,0.05176094,0.0029006884,0.10642012,-0.0026952466,-4.209131e-33,0.04501197,-0.008675414,0.033466727,-0.017444536,0.043508124,0.039161943,-0.09511325,0.041123483,-0.06965727,-0.048985194,-0.09543745,-0.06789447,0.03711661,-0.010424144,0.03173584,-0.019129328,0.08507381,-0.03909526,0.07921161,0.032499272,0.009770219,0.040237874,-0.01565737,0.0636669,-0.011878177,0.06494126,0.01268875,-0.014440217,0.016898556,0.008085451,-0.056211255,-0.1538894,-0.03925641,0.028632699,0.008490604,0.03449028,-0.046416797,-0.08185068,-0.011536559,0.05001335,0.03560416,0.012417631,0.04676854,-0.049466338,0.07724335,-0.059444092,-0.07917821,0.096174665,0.004515595,0.0612769,0.0029180157,0.018926548,0.019807637,-0.09747831,-0.050614994,0.026353799,-0.059838075,0.07167404,0.08430013,0.00593893,0.0023258303,0.08002443,-0.06685857,0.011683866,0.08565944,0.039667536,-0.057011865,-0.055732694,-0.08095959,0.030743152,-0.07568254,-0.012940153,0.09074276,-0.019631876,0.0639515,-0.05964261,-0.065717354,0.023757393,0.043355335,-0.020601675,-0.038677804,0.04387324,0.031905953,0.05593026,-0.033333194,-0.030457022,0.08570264,0.03421862,-0.009818698,0.032359604,0.07328863,-0.04684241,-0.09848205,0.021725442,0.033867683,1.4251208e-33,0.040166184,-0.05595809,0.054037232,-0.09666641,-0.049706314,0.082069196,0.0400721,-0.038713165,0.08682816,0.09766024,0.14615878,-0.0065751607,0.000113050286,-0.08991004,0.06339726,0.040711135,-0.10985374,0.032952722,0.0022836896,-0.010597576,0.020169819,0.027552528,0.010911511,0.06798889,0.051632956,-0.021504799,0.06611536,0.09532089,0.04583088,0.029346064,0.017115533,0.038328294,-0.03174192,-0.08240892,-0.04025129,0.01341599,-0.08662322,0.026388692,0.033018276,0.012978946,-0.020192197,0.001708456,0.0019976455,0.005632881,-0.013370415,0.057775956,-0.08264868,-0.018766398,0.0088924235,-0.009724851,0.024589134,-0.019170435,0.0018156564,-0.06774503,0.02254599,0.034742758,-0.08602014,0.023443269,-0.06829557,-0.058994357,-0.021178447,-0.05744814,-0.002619709,0.020800844,0.027994024,0.03208284,-0.017153086,-0.064867444,0.038031444,-0.043617826,0.11049815,0.039611023,-0.06299458,-0.040761024,-0.047293175,0.025511436,-0.04119788,-0.068429925,-0.030288167,-0.010818997,0.0053385673,-0.021062909,0.027737703,-0.099741995,0.014100102,-0.029549973,-0.062955305,0.15613867,0.09065522,0.03489951,0.021278305,-0.007614617,-0.08198057,-0.046961874,0.07992117,-3.251362e-08,0.018401984,0.004751259,0.083889514,-0.03762887,-0.013436937,-0.0037052962,0.0038239316,-0.07009191,0.06741263,0.018819762,-0.026011722,0.030599942,-0.076774605,-0.028741535,0.049772102,0.0056970776,0.014770489,0.05353579,-0.021322753,0.031019522,-0.064758636,-0.042925987,-0.102438,0.028677588,-0.017029617,-0.061508115,0.04847229,0.029707043,-0.004371154,-0.038006052,0.030651834,0.03420932,0.028403407,-0.07911995,-0.057114683,0.00684605,0.031288005,0.046767715,-0.0669274,0.088936925,0.03389247,-0.084296055,-0.04066458,-0.023454668,-0.010523957,0.00575842,-0.0068734935,-0.023803616,0.033442404,0.019501643,-0.018244049,-0.011151054,-0.041839443,-0.07775071,-0.06646618,0.06638996,-0.0004732138,-0.07109985,-0.062317424,-0.096771,0.036420718,0.017621536,0.19522706,-0.01814466 +1.1.1.105,"The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form [2]. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis-retinol dehydrogenase). Also active with 3alpha-hydroxysteroids [2].",384,0.99999994,-0.041957002,-0.06735754,-0.061162855,-0.080430545,0.027666181,0.050075416,-0.017192803,0.03549371,-0.020435052,0.013462224,-0.0004089673,-0.050882537,-0.060754072,0.0717671,-0.007870714,0.018175658,-0.022907399,-0.021418981,0.060146548,-0.070484586,0.041066963,-0.023525639,-0.005968335,-0.010055584,0.014717179,0.006540751,0.045477167,-0.011045465,-0.019978242,-0.031314123,-0.08173954,-0.0024670989,-0.08419432,0.0007439944,-0.0005661248,0.09187746,-0.040572967,-0.092013925,-0.042475007,0.060737178,0.014450413,0.0037603406,-0.09971115,0.039840713,0.068500854,-0.085957125,0.030268073,0.069264315,-0.0005693453,-0.0034421494,-0.025924329,-0.03132117,-0.041790348,0.065215416,0.066974595,0.07946794,-0.045555744,0.04334841,0.04857028,0.049953226,0.004249749,-0.08707854,0.082463354,0.008601358,0.054811615,-0.055720165,-0.020825544,-0.070412554,-0.037857406,-0.030754784,-0.11343438,-0.0062145526,-0.017230853,-0.031595014,-0.057334572,0.013679957,-0.06931483,-0.047835913,0.033853076,-0.013439601,0.024040448,0.04584917,-0.0017540624,0.057353716,0.1388915,-0.02414448,0.00050263054,0.015109958,0.017294314,0.028389994,0.014283669,0.0077893483,-0.038284805,0.029861907,-0.11359154,0.038457766,-0.00069954497,-0.007814123,-0.056353945,-0.06416699,-0.0045543117,0.05520304,0.04970655,-0.019675331,-0.132239,0.03503263,-0.0261581,0.12129825,-0.08067081,-0.0061360495,0.0068004043,0.02940755,-0.0030073097,0.0015189227,-0.0028569524,0.12391393,-0.029360102,-0.10171678,0.065868795,-0.030928267,-0.060014185,-0.022087503,0.07307848,0.021966828,0.016762475,0.059455555,-0.060650535,6.322106e-34,0.05319402,0.052365657,-0.024352774,0.01354708,-0.019500056,0.046516605,-0.08516037,0.09062115,-0.1295398,-0.027583597,0.00812812,0.014749067,0.06252506,0.039152246,0.0062092487,-0.005964913,-0.0067217844,-0.017527258,-0.009945496,-0.033968735,-0.04829475,0.06849704,-0.061528403,-0.02006509,-0.058798194,0.03549781,-0.036732927,0.06749494,0.0077280616,0.009704525,0.03469983,-0.008968112,-0.05531265,0.025955232,0.060288403,0.016214592,0.03208264,-0.041877847,-0.06832996,0.032323033,-0.004332197,0.0131972,0.013716655,-0.112369254,0.07844555,-0.056703374,-0.03386696,0.0489416,-0.059594613,0.027144743,0.033387996,0.0059860926,0.03363863,-0.095359795,-0.078813836,0.03307103,-0.07835277,0.04845561,0.05815746,0.05463392,-0.037889652,-0.012199774,-0.0348358,0.116512135,-0.00080430007,0.053909488,-0.073850036,-0.079663835,-0.038438212,0.057207268,0.039773323,0.02256205,0.061365776,-0.0416616,0.06846829,-0.0095779225,-0.00196156,0.06303542,0.0068854573,0.07511368,0.011104173,-0.008778522,0.05184169,-0.0410216,-0.021241093,-0.03088669,0.030228917,-0.040683724,0.016212618,0.016580159,0.122070484,-0.03577066,0.02570752,-0.008319943,0.04747238,-1.5453166e-33,0.054221515,-0.09888749,0.05025872,-0.14575768,-0.069588766,0.115762725,0.062113166,-0.09221971,0.06947068,-0.08735337,0.08046745,0.019627381,-0.072429866,-0.05558827,0.011928226,-0.06226349,-0.054089975,0.0030343814,-0.036713134,-0.00057690794,0.018109372,0.0675688,0.029184617,0.074822955,0.005919932,0.049709678,0.002271217,0.06705478,-0.024253685,0.043171242,-0.017023575,-0.016929604,-0.057472944,0.060862605,0.005934566,0.0058316453,-0.13063824,0.019834751,0.026591025,0.07159882,0.03255675,0.013414206,-0.04749313,0.007953509,0.011211572,0.071377866,-0.0644802,0.03390113,0.021892235,-0.052060224,-0.033224996,0.027307712,-0.04169676,-0.028886138,-0.0019077454,0.045156587,-0.032833427,0.013852454,0.07944948,0.029252289,0.0042465003,-0.052990094,0.011028423,0.01588462,0.056167096,0.05713032,0.029338475,0.0025478445,0.08152803,0.0014802967,0.106835365,0.026318302,-0.009710079,0.05755405,-0.026777174,-0.04295345,-0.0366241,0.03198851,-0.08296803,0.041599385,0.009210288,-0.048055124,-0.063306056,0.0040541478,0.028015604,-0.012108459,-0.049242917,0.024522645,0.060771063,0.004206326,-0.016750716,-0.008367247,-0.10043729,0.02596422,0.06982492,-4.009646e-08,0.049743954,-0.023202913,0.07595587,-0.06897212,0.040288724,0.022400003,-0.0002602056,-0.02517367,0.04812063,-0.013989603,-0.0215475,0.03296088,0.026647575,0.0713754,0.042604033,0.02563982,0.020677255,-0.009839033,0.007843379,0.025430027,-0.08472957,-0.05904144,-0.036203053,0.047280766,-0.03971919,-0.056612123,-0.020578546,0.04921375,0.059476048,-0.015315777,0.06360399,0.007863652,0.098124124,0.023108035,-0.083796464,0.023634585,0.0067512505,0.06358701,-0.090786465,0.062799536,-0.006897629,-0.08169969,0.029210575,-0.0024043585,-0.035422727,0.022131572,0.054701645,-0.04628923,-0.040809162,0.0348428,-0.023680506,-0.02108586,-0.01874905,-0.038982686,-0.10322374,-0.06436965,0.0024634234,-0.06721083,-0.046472427,-0.08991226,0.027628424,0.02517109,0.07985374,-0.009211821 +1.1.1.107,The enzyme acts on the hemiacetal form of the substrate.,384,1.0,-0.040491756,-0.038174164,-0.07512239,-0.012752478,-0.0214193,-0.046372842,0.008041314,0.033399828,-0.008549223,0.019163335,0.026366279,-0.033863243,-0.040294316,0.071853414,0.010923329,0.03244958,-0.08656076,-0.052370317,0.019698044,-0.026681524,0.086080536,0.029597305,-0.047341008,0.025557214,-0.0013571939,-0.023901587,0.091340765,-3.7292877e-05,-0.022988606,-0.07001204,-0.0779222,-0.045274455,0.10553094,-0.030520113,0.01863887,0.058131285,-0.06892394,-0.09266943,-0.01335963,-0.016391035,0.09229136,-0.042188887,-0.08620885,-0.0060867523,-0.08747956,-0.017152041,0.086367905,0.021630118,-0.0030800633,0.10134135,-0.031011684,-0.076237,-0.031035446,-0.0012803945,-0.0659257,0.014832262,-0.03880538,0.033458803,-0.008848598,-0.03122295,0.016002212,0.019152327,-0.06527045,0.00366371,0.05120216,-0.09010142,0.041615196,-0.029218884,-0.043079022,-0.035743326,0.0046754507,-0.083253965,-0.03554272,-0.0015833918,-0.0073935203,-0.04908554,0.050533727,-0.032603774,0.05198162,0.05044096,-0.01742076,0.0070574456,0.015098089,0.11506552,0.04838636,0.1307939,0.002208286,-0.024433672,-0.022139212,-0.0029802022,0.025267825,-0.016580142,-0.061030053,-0.08937007,0.012974652,0.017018605,-0.007473681,0.02147161,0.05455983,0.015847376,0.025512174,0.035448562,0.02246672,-0.0139208175,-0.06634407,-6.106428e-05,-0.022206692,0.034508646,0.060775388,0.014173447,0.0013152745,0.038882755,0.086655565,0.058451623,-0.0521022,0.12677436,-0.019532837,-0.050906826,-0.03048217,0.02828249,0.0072933817,0.013433605,0.05306557,0.0699517,-0.034745414,0.011705619,-0.09526396,-4.9238736e-33,0.02044804,-0.019734047,-0.004185733,-0.07482266,-0.032201745,-0.039164692,-0.060214557,0.014701129,-0.047818728,0.008267412,-0.07068958,-0.06554594,0.07373309,0.053473413,-0.0047690766,-0.044453785,0.0066232537,0.01748145,0.008142034,0.053114355,0.004675149,0.02430739,-0.03871543,-0.006948912,-0.024386724,0.07776853,-0.07487176,0.050240476,0.023376746,0.011926214,-0.0002702874,-0.08154073,-0.061767023,0.0067140046,0.080022335,0.03510891,-0.029951178,0.015497126,-0.04364923,0.043120336,0.036579378,0.008438279,0.012461946,0.0057798484,0.074678086,-0.06436798,-0.028334612,0.07312585,0.03289226,0.03194936,0.047167677,-0.06030136,0.16709755,-0.08949467,-0.045560256,0.05669953,-0.060944032,-0.049734782,0.0401698,0.016302586,0.052833937,0.059530042,-0.040249698,0.09951071,-0.002698979,0.07079585,-0.04521168,-0.045794792,0.021387419,0.07776887,-0.036553062,0.03875813,-0.0119226985,0.015396536,0.009853621,-0.007356429,-0.073076144,0.023909729,0.05889738,-0.03961706,0.0036293867,-0.09050316,0.008366841,-0.026803521,-0.04115427,-0.04025091,0.02782274,-0.07421207,-0.04135142,0.049703486,0.066631906,-0.09495097,-0.05231987,-0.02738164,0.0406896,2.01224e-33,0.06503081,-0.085917234,0.0037944745,-0.09870874,-0.052329406,0.070236236,0.019058723,-0.014706097,-0.062959455,0.044811867,0.04378202,0.043085553,-0.084215574,-0.039273,0.052409787,0.07681887,0.0040629497,0.018951382,-0.017567141,-0.032977395,-0.04678805,0.047804225,0.047519818,0.011795989,0.059824698,-0.020021949,0.031663217,0.053464428,0.06327894,0.022238875,-0.0968735,-0.025258895,0.0042738034,-0.023579381,-0.007956177,0.092009425,-0.016155588,0.01503942,0.050116625,-0.0720402,0.002007839,0.021281715,0.05808036,0.123511076,0.016984928,0.047964666,-0.08522251,0.022117818,-0.08509624,-0.07372734,0.02534038,0.01726337,0.04546107,-0.00722939,0.042622875,0.06725487,0.02551141,-0.0027253036,-0.049922932,-0.020579632,-0.05306323,-0.0019756306,-0.012139392,0.011353325,0.065713175,0.010101097,-0.02760493,0.032965332,-0.017634362,0.011936791,0.073365115,0.0521584,0.02553387,-0.015337826,-0.07679862,-0.045091942,-0.028142286,-0.012185755,0.021453653,-0.06431868,-0.04125594,0.02744962,-0.010125018,-0.07314479,-0.011494808,-0.074213214,-0.010236277,0.09501396,0.0038338928,0.06571938,-0.021196643,-0.026404312,-0.05221434,0.04516394,0.057848256,-2.2555161e-08,-0.004450413,-0.08994499,0.006486525,-0.08338525,-0.014637805,0.093279675,0.013855592,-0.038479507,0.059246667,-0.0016538218,-0.088216126,0.079535544,0.05317662,-0.0018744518,0.024748841,0.040115755,0.00028188716,0.019336399,-0.055480443,-0.02744036,-0.055862367,0.016801732,-0.08493297,0.04842409,0.0561428,-0.10941845,-0.038004704,0.07707884,-0.03413535,0.03541502,0.0103524905,0.07657584,-0.009344996,-0.045783103,-0.0859597,-0.018869467,0.0119081205,-0.03445543,-0.026867766,-0.0025513808,0.028625403,-0.03695964,-0.04629382,-0.038223185,0.03789578,0.017560113,0.0038184044,-0.029708616,0.056918453,-0.011271417,0.0305449,-0.016386772,0.013806525,-0.0028742638,-0.06152457,-0.02582946,0.01693863,-0.094385184,0.01664957,-0.018486438,0.0660191,0.10073161,0.24471216,-0.046502523 +1.1.1.110,"The enzymes from anaerobic bacteria such as Clostridium sporogenes participate in the fermentation pathways of L-phenylalanine, L-tyrosine and L-tryptophan. The enzyme from the yeast Candida maltosa has similar activity, but, unlike the bacterial enzyme, requires Mn2+ and can also use NADPH with lower activity.",384,1.0,-3.8324462e-05,-0.05978322,-0.08456399,-0.020296477,0.09514311,0.067284815,-0.041271735,-0.0050494405,0.0226961,0.022991296,0.016516043,-0.033300586,-0.05900596,0.11775612,-0.007110717,0.049725592,-0.056840118,-0.006105273,0.064298935,0.017090783,0.13358256,0.06846184,0.01536429,0.013876219,0.025741747,-0.013106041,0.029091852,0.0048299134,-0.03432081,-0.025180737,-0.08085053,0.020009149,0.09167758,-0.07192334,0.05326606,0.11723501,0.026094405,0.044586197,0.08986795,0.0010986673,-0.011542079,-0.0042549074,-0.008211921,-0.038774926,-0.05811196,0.012116546,0.02781168,-0.03148649,-0.008124725,0.015603134,-0.09696662,-0.05238245,0.026444357,-0.014322428,0.028248936,0.02027278,-0.04676633,-0.0021513782,0.0032761933,-0.025146259,0.0056542307,-0.040057328,0.0019649798,0.032337606,-0.014737474,-0.11252692,0.033500567,-0.04230006,-0.027247103,-0.058164164,-0.033678018,-0.0554173,-0.017351886,0.018161168,0.02832624,0.07120712,0.082646735,-0.07511272,-0.040894102,-0.0619979,-0.016503269,0.008171991,0.01892717,0.051360235,0.035736207,-0.014004986,0.020710817,0.05984326,0.08266887,0.018866023,0.03200186,0.043273885,0.016560957,-0.03765328,-0.027000032,0.022604728,-0.016410945,-0.007602938,0.014623209,-0.01164707,0.002235434,0.04323842,-0.03299682,-0.078634396,0.044972572,0.022164142,0.066540174,0.08403111,0.04345497,0.02817758,0.057998475,0.0476937,0.06704,0.010120614,0.008711472,-0.012362997,0.052673653,-0.049156785,-0.06860049,0.0020871204,-0.014711439,-0.024743741,0.020004667,0.014911765,-0.050613567,0.03332145,-0.067041814,2.287432e-33,0.11366538,-0.008685399,-0.04236776,-0.0037139761,0.0108986115,-0.00534008,-0.044610016,0.0075685047,0.05652766,-0.033949863,-0.09321547,-0.07225882,0.045694903,0.039194033,-0.037222933,0.017764464,-0.025963478,-0.038513456,0.031396605,0.065439686,-0.0026495,0.027799543,0.011482499,-0.002919958,0.08280967,0.022857334,0.065004006,-0.02320457,-0.00816171,-0.04201205,0.049612556,-0.12758563,-0.061130874,0.0052816765,0.092055835,0.040453363,-0.026655875,0.017373752,-0.037860237,0.01094817,-0.026821945,0.07338357,-0.040887445,-0.017352566,-0.030967724,0.00015943975,-0.04712768,0.097315535,0.040086545,0.08995091,0.037083045,-0.010161398,0.004410072,-0.0238286,-0.04423417,0.061909925,0.00040676567,0.040940505,0.06478801,0.037428595,-0.034220994,0.01901352,0.029757798,0.07428778,0.034373276,-0.06495341,-0.055602297,-0.07852192,0.014689921,0.038254566,-0.10037917,-0.0711854,0.03430187,0.013644928,-0.011696743,-0.09226349,-0.09594082,-0.13834004,0.0058438494,0.030909281,0.02745829,-0.13587087,0.0017313618,-0.06393528,-0.10021166,0.020397827,-0.046095554,-0.0469135,0.021469627,-0.088360265,0.007662328,-0.06860588,-0.00018099934,0.038519047,0.02280388,-3.5344437e-33,0.09487326,-0.07013839,0.1313004,-0.12223308,-0.09774814,0.09364296,0.023497287,-0.09883708,-0.09286042,-0.00707445,0.044405024,-0.012895524,0.012514714,-0.0016821716,0.0044626542,0.0074499203,0.029924722,0.060307045,0.03155016,-0.012909907,-0.04345868,0.16025516,-0.026807625,0.020405186,0.079580985,0.04084592,-0.043339264,0.13561034,-0.008292913,-0.0028011748,-0.00036393484,-0.0076585575,-0.008543315,-0.08222853,0.0066302544,0.052844565,-0.09740654,-0.012017559,0.0040437225,0.030330006,0.05246862,0.011562229,-0.0112524545,0.04143224,-0.05607853,0.033829674,-0.083002485,-0.010092054,-0.0029947995,-0.048571076,-0.014304202,0.002128631,-0.049503513,-0.049658705,0.08643822,-0.0026634678,-0.06402362,9.225376e-05,-0.012335668,-0.04915633,-0.04727513,-0.035616945,0.050455682,0.02080759,0.02270985,0.074230604,-0.032118432,0.0237289,0.036721356,0.0046018907,0.01738538,0.038448196,0.04902045,0.06997864,-0.090423234,-0.06729413,-0.07125997,-0.061903283,0.026561266,-0.022611193,0.03438982,0.0043411194,-0.0032260695,-0.002501633,-0.016966943,-0.0031660197,0.02770218,0.02134373,-0.002995815,0.021360999,0.020641431,-0.020118246,0.028971184,0.017251905,0.04689803,-3.7047812e-08,0.038376246,-0.03651419,0.07670516,-0.016508253,-0.064784266,-0.03243024,-0.03435934,0.0066325543,0.05197618,-0.015687244,-0.011377737,0.06173198,0.018383518,0.033523347,0.0461424,0.025940854,-0.07735071,0.056552786,-0.053426977,-0.011504035,-0.0801364,-0.032068975,-0.15461725,0.11888601,0.034484573,-0.008370024,0.0016814838,0.055630263,0.08401972,-0.064338,-0.029645994,-0.0059398953,0.048121087,-0.031160612,-0.04103201,0.044181,-0.060245454,-0.04562267,-0.038156375,0.0025234458,0.018410241,-0.077981405,-0.046522047,-0.006710132,-0.089571685,-0.031281665,-0.025108486,0.009464898,-0.009245338,-0.029470246,0.04507922,-0.01304357,-0.017179258,0.018786203,-0.06874038,0.050971203,-0.007966321,-0.034830578,-0.02137566,-0.0397646,0.02441898,0.008442556,0.12961972,-0.11556393 +1.1.1.112,"3(20)alpha-Hydroxysteroids are also oxidized, more slowly.",384,1.0,0.044507783,-0.09038908,-0.011545181,-0.010508259,0.034520894,-0.01687164,-0.06584311,0.028836383,0.03148298,-0.02327815,0.04042985,0.112392634,-0.044773564,0.05111019,0.015902197,0.09504153,0.002607298,0.077370174,-0.03858532,-0.009601705,0.016070655,-0.048489425,0.020615233,0.047005974,0.048307862,0.067010075,0.0022948214,0.024497233,-0.010954444,-0.028103996,0.021731045,0.08974979,0.022152668,-0.022941412,-0.07853382,-0.0109853195,-0.096269526,-0.035619143,0.019154819,0.09790994,0.035500545,-0.02465386,0.0038754356,0.023747807,-0.06077008,-0.022065492,-0.07411527,-0.0001633895,0.036430374,0.06457719,0.022458242,-0.05990098,-0.037260864,0.03039433,-0.039746556,0.01999577,-0.06335818,0.03623558,-0.0057356097,0.056546934,-0.05001006,0.036205508,-0.0017459613,0.022068575,-0.015772851,-0.0015434363,0.030831598,-0.087566406,-0.028113933,0.008124317,-0.032002587,-0.02400803,0.03652493,-0.012528574,-0.12892894,-0.005281939,0.058571775,-0.08992878,0.035115633,-0.0028685757,0.0011164838,-0.010713945,0.017144786,0.14143443,0.015000974,-0.017934022,-0.06573869,-0.060823306,-0.1018989,0.079769865,-0.020372994,0.10026716,0.0040065916,0.030575732,0.03287707,0.025289688,0.0041554878,0.045166954,-0.07052615,-0.002652665,-0.016671315,0.071589105,-0.06306371,-0.058251165,-0.0452435,0.016101837,0.017279677,-0.011663739,-0.0779252,0.08104077,0.017060388,-0.026727015,0.020534376,-0.0093482165,-0.05499988,0.11175007,0.015508245,0.008226107,-0.009934285,-0.027179737,-0.025988016,-0.031139161,0.033824604,-0.056005362,-0.09203787,0.0033096322,0.09120203,4.97163e-35,0.013120202,0.036116853,-0.02747921,0.045638494,-0.0832183,0.06145925,-0.05973139,0.006863463,0.053859662,-0.024578385,-0.08200541,0.0131357545,-0.0056551755,0.012643332,0.0082402425,-0.117918245,0.009378798,0.057724647,0.028713154,0.0036092766,0.035198707,0.023099566,-0.033036847,-0.032009706,-0.03431089,-0.014023377,-0.037563737,-0.011915012,0.009009046,-0.02255654,0.036748998,0.051247884,-0.08353047,0.043736484,-0.1179636,-0.0060485452,-0.053645197,-0.052171577,-0.0026239154,0.044915523,-0.021770881,0.040255327,0.041730955,-0.024100397,0.08130829,-0.04344497,-0.03099544,0.04150106,0.07717146,0.03402965,0.02679994,0.062189005,0.01513139,-0.021956066,0.0009675102,-0.0073851817,-0.02350884,-0.0033244456,0.00092258357,0.07672397,-0.0048927595,0.07104681,-0.004203715,0.014446231,-0.013308833,0.091221854,-0.018154439,-0.012764992,-0.048061885,0.011915216,0.05526989,0.004476264,0.09311034,0.013330594,0.037735432,-0.01315069,-0.008198684,0.046493348,0.0023796072,-0.08516322,0.0023127873,-0.021243757,0.009416141,0.105883144,0.0043485677,0.018085673,0.02775336,0.027645105,0.07135708,0.027226742,0.073159784,-0.12901679,-0.099277094,-0.028662654,-0.011547643,-5.4729006e-34,0.058820985,-0.096022666,-0.055170063,-0.041669082,0.0017680858,0.04424689,0.017709823,0.06915313,0.021361554,0.002452311,0.00263483,0.03433943,-0.09473047,-0.11726018,0.063351125,-0.05135531,0.021631133,-0.0016749183,-0.05649272,-0.06266001,0.08005553,0.086634815,0.023033306,0.10292239,0.05544073,-0.01010697,0.051685475,-0.037602607,0.04213749,0.08582086,-0.011683349,-0.0047570216,-0.0057568727,0.008305444,0.06658443,0.089677416,-0.048299007,0.01079807,-0.04489105,-0.060577895,-0.079165734,0.018722694,0.010080645,0.061778914,0.05566341,0.06058698,-0.09522179,-0.049328152,-0.0006133448,0.05322914,-0.01521942,-0.030676797,-0.05507344,0.015066412,0.004679233,-0.04688207,-0.07728899,-0.09155764,0.03295978,-0.030386368,-0.018166361,-0.008589714,-0.007334183,-0.061070137,-0.03891579,0.042043943,-0.05443326,0.065662324,0.047509577,0.07875172,0.03715216,-0.007903249,0.017891852,0.035113018,0.038615637,-0.079680376,0.02773933,-0.03366713,0.0011970503,-0.026457347,0.0048634023,0.02228138,0.0006669607,-0.014174008,-0.0419342,-0.05424168,-0.007731591,0.023564458,-0.026630903,0.083768114,0.021239152,-0.039489675,-0.05061497,0.04663081,0.05086923,-2.229546e-08,0.051760215,-0.014584902,0.12992504,0.0315418,0.0106963655,0.022384532,0.021921754,0.09713187,0.087264225,-0.080755085,-0.00014430471,0.074191906,0.07526461,0.010576742,0.030926626,-0.04946692,0.019781819,-0.028545795,-0.039855037,-0.032020345,-0.14233539,0.01897611,0.012851585,-0.022132173,-0.0065368707,-0.00830018,0.02585304,-0.019000454,-0.020779347,0.006880491,0.053317323,0.007925093,-0.00391719,-0.028930493,-0.034859974,0.06110977,0.052575402,-0.02795553,-0.021763815,-0.0369957,-0.13063055,-0.14836094,-0.0042509465,0.050388727,0.058993608,-0.10321465,-0.038554456,-0.039881222,0.0075202333,-0.06939098,0.03229899,-0.023254298,-0.047546808,-0.051328417,-0.07355976,-0.038329642,-0.038666397,-0.04730629,0.028356094,-0.06289767,-0.042237896,-0.024496933,0.18736924,0.0077821384 +1.1.1.113,Also oxidizes D-arabinose and D-lyxose.,384,0.99999994,-0.056675076,-0.033736426,0.0092688035,0.022327978,0.057807874,-0.019806387,-0.021764534,-0.0029939148,0.025556922,0.027489867,0.0030442965,0.08381599,-0.021172376,0.023379114,-0.030720362,0.060787655,-0.0267382,0.13340302,-0.078015745,-0.043931793,0.08073489,0.02556149,0.03789922,0.014972512,0.060793523,-0.0064823814,0.029487373,0.020531615,-0.033065274,-0.10845211,0.003993946,0.03469983,0.02502624,-0.04300131,-0.019673076,0.11141521,-0.011184534,-0.0030393873,0.033353407,-0.0077921464,0.056236956,-0.045500737,0.069481574,0.004643235,-0.057149313,-0.0062100543,-0.0728414,0.039997652,0.02884591,0.048803676,-0.019913401,-0.06502233,-0.037249215,-0.00741382,0.012778538,-0.00055356754,-0.06411363,0.05185457,-0.0417555,-0.018219134,-0.012774084,0.055521525,0.008768955,0.04415435,-0.046624336,-0.044206154,0.083301395,-0.019469377,0.009086496,-0.051754992,0.003502124,-0.058946393,-0.017652053,0.025296567,-0.016306976,0.036143433,-0.015349227,-0.16059823,-0.015660144,0.009740219,0.038537204,0.05569802,0.05134262,0.07814126,0.053462595,-0.023084663,-0.0055876803,-0.07128249,-0.053161982,0.016717056,0.062425613,0.004171647,-0.0010087356,0.018453598,-0.027114013,-0.027025918,0.049269255,0.067508504,-0.08747238,-0.039132874,-0.05618878,0.054760735,-0.07589814,-0.085792854,-0.05109248,-0.013368201,0.0025290444,0.04210896,-0.010029185,-0.058445927,0.02492286,0.01641788,0.029924897,0.030834835,-0.09100378,0.048651345,0.04139179,-0.061409365,-0.05242283,-0.015488515,-0.016425418,-0.064131185,0.04408052,0.009034552,-0.026267428,0.035342187,-0.039617542,1.9354044e-34,0.027826631,-0.020140465,-0.012676467,0.04935052,-0.0374509,-0.025711985,-0.12550758,-0.0150092365,0.012442352,-0.021468388,-0.115301825,-0.014205285,0.015258509,0.08164823,-0.0040138634,0.012161546,0.0382152,-0.03540437,0.060728475,-0.013772478,0.045835763,0.028268622,-0.026367579,0.003423384,0.047280453,0.02240165,0.073436506,0.0053931475,0.035371177,0.0067016957,-0.002611071,-0.06767526,-0.051927965,0.049654767,-0.08176279,0.09853857,-0.13995954,-0.009958872,-0.067693286,0.037256137,-0.025851326,0.01152492,-0.013166215,-0.04365177,0.06149195,-0.037103496,-0.057796225,0.08004435,0.03103747,0.07715675,0.07011414,0.020083562,0.06762817,0.0047558118,-0.045216314,0.0071660765,-0.020708486,-0.09059824,-0.024479192,0.091103315,-0.035850998,0.057372246,-0.04648699,0.019968586,0.04467096,0.013181063,-0.032882713,-0.044486582,-0.10784993,0.014585479,-0.068345375,-0.06806889,0.14037856,0.032655254,-0.030486561,-0.017617447,-0.042976923,-0.0059738667,0.04219292,-0.012900737,0.050403696,-0.0862718,-0.0130036045,0.028772509,-0.071796685,0.022771215,-0.006386184,-0.0031575626,0.022287544,-0.023191376,0.062129054,-0.07404421,-0.062639885,-0.025517406,-0.00063658325,-1.9174859e-33,0.051915724,-0.038193036,-0.002443999,-0.008747068,-0.027156582,0.041932903,0.052897353,0.03904431,0.038728397,-0.06373495,0.04077913,-0.01706738,-0.098403335,-0.05338718,0.023594555,0.012681304,0.009670044,0.03695446,-0.06579127,-0.011292309,-0.045542326,0.113620356,0.0459032,0.0129140215,0.1293772,-0.014995969,-0.01026829,0.031503096,0.0010376007,0.075772084,0.07508442,0.035080876,-0.07297932,-0.02991083,-0.046709497,0.07645009,-0.09560599,-0.016962772,-0.039184183,0.0072905696,-0.02031915,0.0027974695,0.071686916,0.06990914,0.08361445,0.09909484,-0.0720304,-0.062880464,0.0406404,-0.041056253,0.027883954,0.051061057,-0.028635569,0.034560937,0.08005147,0.04044362,0.012983044,0.0028960726,-0.038767707,0.005985778,-0.04281115,-0.023433251,0.043243658,-0.050864674,-0.003139087,0.013694839,-0.040878303,0.04604505,0.061253387,0.027357824,0.12702946,0.012249748,-0.011640792,-0.014298774,-0.040704526,-0.050739862,-0.09578763,-0.030512035,-0.03350694,0.020523055,-0.015623762,-0.011657454,-0.044613615,-0.015264117,-0.01118025,-0.06655807,-0.043436393,0.07228347,0.0011503041,0.051107742,-0.062000245,-0.061851267,-0.04283746,0.042701803,0.04533522,-2.135873e-08,0.022882033,-0.051088903,0.08199431,-0.02050695,-0.035891775,0.031444136,0.057588443,0.16569361,-0.015265462,-0.023599837,-0.043145772,0.14019011,0.017002814,0.02711998,0.038436003,-0.0078874575,0.036499027,0.041746497,-0.04318918,-0.021129914,-0.08864331,-0.03632815,-0.06595949,0.039399475,-0.020811269,-0.046894994,0.09488027,-0.007339037,0.07319401,0.007398603,0.03856141,-0.012478733,0.0026529925,-0.059251208,-0.06425219,0.002451047,-0.025121717,-0.015862767,-0.018277137,0.010015515,-0.049239073,-0.040081188,-0.06652355,0.07607863,0.007288915,-0.07198542,0.0071140714,0.036753412,-0.05296128,0.027229143,0.10802597,-0.025219861,-0.04544729,-0.04381704,-0.088732444,0.0273197,0.027350582,-0.013386001,0.023397066,-0.047365446,-0.0010370035,-0.039239775,0.18184085,-0.04016362 +1.1.1.115,"Also acts, more slowly, on D-xylose and other pentoses.",384,1.0,0.01986985,-0.17055736,0.0043891342,0.040737297,0.014751865,-0.03816825,0.03157043,0.03338676,0.06359685,0.017812207,0.047981627,0.032932013,-0.114645116,0.09542088,0.029724594,0.013427482,0.02811681,-0.023512982,-0.045825664,0.03742771,0.12122532,-0.044199526,0.032755945,-0.04868535,0.03140539,-0.03201274,0.004265665,-0.021306902,0.0041127824,-0.13581902,-0.024943767,0.008483426,0.01881204,-0.08578936,0.09501894,0.053783648,0.036683295,-0.0038856142,0.023141285,-0.054080278,0.051101826,-0.05726741,0.044474524,0.01190007,-0.072816126,-0.010852247,-0.06572708,0.04114305,-0.0036965034,0.015875641,-0.04125781,-0.12652035,-0.020864172,0.004077133,0.06371686,0.007969165,-0.066150494,0.0051690685,-0.01466479,-0.08498215,-0.033024315,0.10113319,0.018191991,0.056359578,0.03370057,-0.051797774,0.031098353,-0.048318673,-0.014048337,-0.006084325,0.0011151201,0.027636068,-0.04815917,-0.016642416,0.00943471,-0.05510015,-0.008276044,-0.098975256,-0.006283562,0.016302804,-0.025515452,0.042925034,0.008385707,0.04469844,-0.023331463,-0.031002969,0.05695752,-0.047067944,-0.090213336,-0.0016681553,0.0058129514,0.008065875,-0.049074486,0.0075685913,-0.034428503,-0.025577987,0.08068321,0.0024485623,-0.027139096,-0.0557668,-0.056715958,0.036289636,-0.022983184,-0.048683815,-0.03503753,0.027955322,-0.008084724,0.057550542,-0.04124365,0.037148934,0.031794805,-0.004328944,0.07388599,0.08959124,-0.09920855,0.022864012,-0.026351359,-0.013213241,-0.022727458,-0.012494557,-0.0038161534,-0.0107623385,0.0018663035,0.10400812,-0.0049967333,0.07084418,-0.0029124066,-2.2573103e-33,0.026906086,-0.02837192,-0.009731764,-0.065552376,0.011279161,-0.03490294,-0.050502915,0.022487603,-0.002516403,-0.0046723145,-0.066388436,-0.08785493,0.049953613,0.047405005,-0.07504804,-0.080623776,-0.012988508,0.03750002,0.011151194,0.057447314,0.032078717,0.04193499,-0.06496413,-0.03194807,0.006412483,0.009954315,-0.05314327,0.05257075,-0.015149066,-0.01762683,0.055520236,-0.02733706,-0.024220014,0.07963505,0.06477083,0.097768,0.00058774557,-0.028551904,-0.010718045,-0.0054910183,-0.026289936,0.015639544,-0.051838767,-0.06129786,0.016864028,-0.024234476,-0.09359717,0.032307643,-0.0033880353,0.053741287,0.08688408,-0.011123159,0.037242502,0.059091434,0.0040983427,0.002824037,0.023246357,-0.037452545,-0.030303214,0.056960754,-0.026154427,0.07196617,-0.046800774,-0.008927887,-0.00842285,0.037710536,-0.06758827,-0.054850984,-0.035255354,0.042170316,-0.12451395,-0.053869206,0.11704699,-0.05292643,0.028783381,-0.061343282,-0.057223022,0.012467332,0.007182255,0.010103656,0.050462905,-0.11306036,0.021829309,-0.06630932,-0.08018314,-0.0128295915,-0.043859668,-0.049439684,-0.000256983,0.0690669,0.013452907,-0.077083156,-0.06725657,0.013131713,0.011617263,-4.3516415e-34,0.0341539,-0.0690418,0.02903577,0.068831764,-0.035495803,0.087445475,-0.001117935,0.0025408068,0.018517582,-0.0753931,0.05839124,0.033297356,-0.107873335,0.019323042,-0.0049890643,0.09525115,0.059580404,0.07912777,0.028787144,-0.030476782,-0.11339526,0.14270541,-0.015784077,0.048748314,0.08737031,0.019095989,0.020381477,-0.014092955,-0.0078120604,-0.019150844,0.015785722,0.0035409823,-0.05090013,-0.044511274,-0.060651135,0.030217746,-0.06897999,-0.016966635,-0.004669208,0.029583683,-0.019286623,-0.006409019,0.07512614,0.074675985,0.0371653,0.08952512,-0.044200122,-0.035504233,-0.034612354,0.09083452,0.008798231,0.0010346471,-0.02731387,0.047923587,0.037022546,0.085130826,0.048143554,-0.06319105,-0.039321266,-0.00030780403,-0.045046322,-0.0070829866,0.041305084,-0.049194645,0.06941675,-0.030881982,-0.09853555,0.06808623,0.09509673,-0.009559336,0.057535253,0.0196302,-0.037738502,0.027525505,-0.073378906,-0.05399737,-0.05998938,-0.07174411,0.030400844,-0.03691406,-0.06169962,0.059511058,0.020613315,-0.05303082,-0.07111329,0.030515924,-0.074196845,0.012731902,-0.026548311,0.094053395,-0.030349921,-0.027777148,0.05328117,-0.009005035,0.11896783,-2.0146528e-08,0.028260063,-0.014154654,0.024035918,0.021010812,0.015167683,0.012363645,0.06911203,0.078561515,0.04799791,0.0066227047,-0.015314315,0.1405116,0.071957774,-0.005640526,0.0635454,-0.0011167983,0.010752962,-0.076560274,-0.053085092,0.013647066,-0.09395508,-0.030397546,-0.10211974,-0.0015725144,-0.038422488,-0.059209514,0.08032635,0.071853824,0.010736598,-0.025257692,0.015744168,0.021352423,-0.0064711305,-0.0015664637,-0.031516448,0.05079914,-0.004068232,-0.039092522,0.004954133,0.033688124,-0.018153917,-0.043101236,-0.046478286,-0.004853388,-0.032119993,-0.0051486543,0.004733447,-0.0447773,0.011679489,0.035335656,0.04254227,0.021106979,-0.045641653,-0.0011108392,-0.012759367,0.07479444,-0.022878032,-0.014692778,0.05617037,-0.0035221537,0.06842564,0.00050080946,0.16889533,-0.025133202 +1.1.1.117,"Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose.",384,1.0,-0.028762814,-0.1553712,-0.013599788,0.03463279,0.05599752,0.042661615,0.008338355,-0.013987723,0.03223901,0.021282028,0.045433406,0.0338992,-0.084913686,0.02235499,-0.019551668,0.06801119,-0.052510276,0.016625877,-0.017044151,0.0691318,0.14598416,0.0068093296,0.025164468,0.0064102244,0.09940419,-0.042584952,-0.002790316,-0.018932404,-0.023788404,-0.11993625,-0.015590007,0.038767762,0.033303685,-0.00071923085,-0.008804104,0.025816502,-0.042427287,-0.06553403,0.060934115,0.01386982,0.026192827,-0.05695232,0.033594716,-0.038179964,-0.020465562,-0.028200291,-0.08142694,0.041248243,0.045542773,0.015473342,-0.004105973,-0.08976737,-0.0882543,0.048126817,-0.013830339,0.04296221,-0.08750198,-0.032219525,0.047040354,0.019318718,0.0036326102,0.07532356,0.0012545072,0.07806044,-0.0040107626,-0.041733045,0.01855269,-0.012247765,-0.019259676,-0.033484712,-0.022335887,-0.07884849,-0.0013670437,-0.042034592,-0.004076141,0.047656544,0.012495497,-0.06579585,0.02826351,-0.036872987,-0.021938778,0.027817953,0.010199418,0.09411075,-0.012019902,-0.04987172,0.0010118029,0.019438975,-0.04586578,-0.009761772,0.030649863,-0.03933856,-0.05581273,-0.00739784,-0.027575655,0.010817224,0.05449729,-0.021993564,0.027311902,-0.011644147,-0.028837148,-0.0085088005,0.007668436,-0.05233849,-0.0001660039,0.029582994,-0.017126495,0.032028075,0.039147135,-0.06053043,0.00025252084,-0.020588603,0.06819412,0.026246373,-0.08606182,0.057647664,0.04494685,-0.069110125,-0.007289246,-0.0677277,0.065813065,-0.029315231,0.0670854,0.024424072,-0.062032886,0.082932115,-0.00055846473,-1.5039414e-33,0.075438716,-0.0015399061,0.025508378,0.014653826,0.06542783,0.027698254,-0.06437111,-0.048106432,-0.03129714,0.038657684,-0.11363061,-0.008004776,0.04094082,0.053072438,-0.034977954,0.033144724,0.02145573,-0.022054125,0.0442587,-0.017520627,-0.025386274,0.08779485,-0.09155078,-0.045541488,0.0044775023,0.022711227,0.008222387,0.028029436,0.005170127,0.00039270148,0.053608757,-0.06184792,-0.005479791,0.0630589,0.02338921,0.102497675,-0.07635321,-0.07134197,-0.0013122017,-0.046829302,0.10029448,0.034858294,-0.07902508,0.0017571037,0.025292281,-0.05826584,-0.053752076,0.059779216,0.043659046,0.061341446,0.080604136,-0.042092904,0.06680352,-0.018194497,-0.027567813,0.059856415,-0.061101507,0.04429174,0.027639437,0.06987716,0.038612273,0.021817591,-0.032096986,0.03908843,0.07074787,0.04069289,-0.050111927,0.003079075,-0.09578728,0.013953703,-0.10772309,-0.06707573,0.12162377,0.011637187,0.007411823,0.014159078,-0.039555296,0.009646713,-0.0039764047,0.0102252755,0.035023768,-0.04187241,0.035243116,-0.010306976,-0.052188355,0.016291538,-0.054002415,-0.09252296,-0.009558492,0.04224929,0.03304388,-0.06908608,-0.029254975,0.009339752,-0.011447958,-9.052588e-34,0.0041216137,-0.09235535,0.08365128,-0.02296279,-0.002408734,0.07252026,0.034800403,-0.03211326,0.05889169,-0.033841852,0.073613,0.0060524684,-0.057512723,-0.11694324,0.032686196,0.06403353,0.030004805,0.079300605,-0.050022952,0.029434245,-0.015333355,0.097468935,-0.03347856,0.047397934,0.048014227,0.0051123705,0.081204355,-0.032160938,0.013434197,0.0043503917,0.03977073,-0.021825327,-0.024291327,-0.08771765,-0.03314127,0.00917836,-0.05656914,0.01435976,-0.041010022,-0.024167461,-0.029126849,-0.044715583,0.069985524,0.09327276,0.09610735,0.04226327,-0.081172906,-0.04649814,0.011528842,0.042330343,-0.023313921,-0.072788,-0.0072062057,0.043614477,0.04066283,0.03549732,0.034118034,-0.057792522,-0.0043868343,-0.014727157,-0.017706051,0.012474762,0.03028877,-0.060203377,0.05398511,0.006362674,-0.082028285,0.012011042,0.001117155,-0.04137981,0.081643544,-0.012756283,-0.064878605,0.0016434044,-0.04560996,-0.055182185,-0.09369953,-0.101858094,-0.018328838,-0.0036181398,0.038313348,0.042540237,-0.0052212696,-0.0118416,-0.024418171,-0.05303333,-0.011037967,0.12875384,0.021633603,0.033799272,-0.06064951,0.0071891933,-0.053883113,-0.0523392,0.07712109,-2.6677977e-08,0.07744302,-0.03651549,0.05946599,-0.09552757,-0.040976584,-0.008697771,0.04312232,0.077285826,-0.009245539,-0.05225767,-0.0017713471,0.13819332,0.013691802,-0.07790003,0.02936402,-0.0625352,0.0047196243,0.06446523,-0.0589514,0.01832691,-0.061223928,-0.023307934,-0.0037221892,0.027628785,0.010692151,-0.09338353,0.042111404,0.06991552,0.0657141,-0.021817734,0.08120988,0.039333954,-0.010171791,-0.045576762,-0.1094334,0.042548943,-0.017811645,-0.045765854,0.0019473078,0.056064244,0.008630135,-0.058281768,0.013726079,0.0037180556,-0.09197111,-0.004951634,-0.011729398,0.02024637,0.0025674128,0.065650605,0.009351965,-0.035293765,-0.09908542,-0.024595719,-0.11248961,-0.02482392,0.035324365,0.012547682,0.0671898,-0.061109126,0.012481232,-0.0067118853,0.1881749,0.017760295 +1.1.1.119,"Also oxidizes D-mannose, 2-deoxy-D-glucose and 2-amino-2-deoxy-D-mannose.",384,1.0,-0.00047235077,-0.035488307,0.01888385,0.017823065,0.027003108,-0.011310944,0.010834756,0.015422952,-0.0083159,0.09930374,-0.005309433,0.028465042,-0.09619893,0.0017479053,-0.023957048,0.02009219,-0.023669116,0.08811309,-0.021733247,0.006070722,0.13255748,0.017902983,0.035592556,0.022342939,0.05385441,-0.00039861148,0.026129838,0.009156909,-0.038847644,-0.1051813,0.0010325066,-0.022940043,-0.016887393,-0.014817682,0.031661727,0.0518617,0.062139854,0.022703376,-0.0024610818,-0.054747675,-0.005321754,-0.0244088,0.020100024,0.027014498,-0.024697924,-0.040671796,-0.111034416,0.050656274,0.0048060953,0.025616406,-0.025288336,-0.019482413,-0.05762791,0.036507633,0.06691015,0.057070725,-0.033761296,0.035630178,-0.039652236,-0.034134775,-0.027809164,0.017455084,0.021662615,0.016897654,0.034522798,-0.078794114,0.048439313,-0.048967417,-0.03957982,-0.049867555,-0.015792603,-0.09953618,-0.010236388,-0.041749172,0.010922725,-0.018294886,-0.015172224,-0.13195474,0.04650991,-0.0011346986,0.02399363,0.022992363,0.111550435,0.063525416,0.0019440104,-0.022666665,-0.003841787,-0.061710626,-0.021018878,-0.029928466,-0.015386141,0.00704814,0.019324759,0.028281366,-0.03280268,-0.013307483,0.02247283,0.08265195,-0.0011379222,-0.010918543,0.012027828,0.06422894,-0.036476888,-0.094487846,-0.015551243,0.014206348,0.027180584,0.029060742,0.03132906,-0.009349588,0.047955927,0.07316232,0.026678592,0.07256613,-0.1025258,0.070158094,0.042733807,-0.022515474,-0.013663722,-0.05573114,-0.009872892,-0.027661834,0.029962558,-0.012551368,-0.059673782,0.037413277,0.006657447,-2.2698864e-33,0.02863879,-0.05457608,0.04098307,0.07867609,0.057919465,0.01713086,-0.09392063,-0.017431311,0.06692607,0.01038894,-0.15938438,-0.036432974,0.018235425,0.088114895,-0.0083861975,0.02634975,-0.045660682,-0.0096782725,0.07237392,-0.012950809,-0.0011459088,0.09064965,-0.016167168,0.024233006,0.08051151,0.0145780565,-0.023416465,0.03854834,-0.0025900067,0.005180154,0.041918203,-0.03929391,-0.06467551,0.013478359,-0.013341793,0.04702617,-0.086055644,0.031265542,0.022744864,0.05533953,0.0122437095,-0.0032429984,-0.023150511,-0.07782018,0.007501785,-0.038339637,-0.0029408021,0.07929259,0.027055344,0.07293796,0.046732385,-0.042480107,-0.0007629304,0.034300763,-0.017845282,0.020922747,-0.008023579,-0.0874448,0.085374154,0.09934452,-0.019143667,0.037455413,-0.009334356,-0.017892778,0.05785854,-0.011967259,-0.04931997,-0.003221701,-0.06284378,0.0019609209,-0.10504559,-0.05930472,0.1228372,-0.01545525,0.00049268274,-0.041517742,-0.0439282,0.03138393,0.04725382,0.005150221,0.08567684,-0.078618914,-0.041328985,-0.030195324,-0.049412973,0.014440981,-0.047913283,-0.072722666,-0.002588165,0.013522122,0.0198179,-0.020510348,-0.122845165,-0.08384048,0.028174112,-9.920898e-34,0.01929538,-0.047052834,-0.005075834,-0.009787074,-0.02446399,0.0048615127,0.076486446,-0.038548637,0.07814881,-0.06795989,0.06875227,0.012327361,-0.06816229,-0.02741708,0.025479237,0.040827375,-0.057868566,0.07270607,-0.038935542,-0.03370209,-6.962459e-05,0.1321299,-0.028417516,-0.0024336532,0.111845754,-0.025958998,-0.037971385,0.0038282073,0.087113,0.042996712,0.07301233,-0.0023396816,0.008096528,-0.0076410975,-0.025355222,0.0038021768,-0.06926504,0.029121289,-0.0846178,0.017119508,-0.07177025,0.03574661,0.07152214,0.041161362,0.09239774,0.03444383,-0.077391975,-0.08540619,-0.04305726,0.024540063,0.05028895,-0.037063733,-0.051526807,-0.0017776395,0.066093005,0.001712517,-0.05351982,-0.01151903,-0.015260285,0.028102294,-0.017551433,0.00876029,0.06007801,-0.043169264,0.00097599573,-0.0011195305,-0.10060383,0.025253814,0.061488874,0.047979902,0.04697353,-0.024986468,0.0030315877,-0.042193502,-0.07788815,-0.043919366,-0.121711,0.017980836,-0.0034249513,-0.022866724,-0.01994806,0.007356072,0.00555628,-0.04186936,-0.067683056,-0.051288158,0.0011979926,0.057590663,-0.0015870248,0.07326181,-0.07806805,-0.010555611,-0.014783115,0.056193855,0.06534983,-2.9834883e-08,0.038641524,-0.012818285,0.08522297,-0.019611252,-0.029858116,0.022209508,0.074035585,0.14337425,0.026727492,-0.038211092,-0.015840465,0.20447479,0.023611875,-0.022726078,0.025085742,0.011908961,-0.014207889,0.019451257,-0.047191788,0.00531849,-0.09330246,0.0016665825,-0.074798845,0.051936395,-0.0027961244,-0.055112746,0.09106853,-0.045339417,0.054340106,-0.004599826,0.039118487,0.04380399,0.052730683,-0.10946505,-0.086627536,-0.020986421,-0.04811917,-0.048458442,-0.009198769,-0.03224421,-0.03248966,-0.04210114,-0.020473156,0.025970573,0.019166328,-0.025326231,3.6505015e-05,0.030629545,-0.061175745,0.020621348,0.030079778,0.041492835,-0.11075828,-0.06435179,-0.11250586,0.05249358,-0.05492024,0.015698649,0.035027605,-0.06597917,0.028905014,0.005561152,0.15563631,-0.049558293 +1.1.1.120,"Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose.",384,1.0,-0.032409593,-0.1251905,-0.012545715,0.021387922,0.027543496,0.04662304,0.0074695474,-0.042292956,0.04270624,0.046591382,0.07848721,0.010335479,-0.08343743,-0.014328239,-0.016043592,0.05695599,-0.058585443,0.038724568,-0.048763532,0.019289,0.12905787,-0.0026592968,-0.0019892566,0.0047230837,0.09096285,-0.035735387,0.008076207,0.0022668443,-0.01689641,-0.12928952,0.023715721,0.03863411,0.031686224,-0.015799923,0.0124033075,0.096741915,-0.026843073,-0.051601447,0.09045208,-0.014112819,0.07040115,-0.076462634,0.06371764,-0.047421537,-0.029293202,-0.010410379,-0.06566105,0.049663864,0.06653669,0.005255993,-0.009636114,-0.10515767,-0.09351543,0.02489478,0.0075999694,0.0050050505,-0.086466625,-0.0016728223,0.014692136,-0.010233905,0.013673471,0.05930984,-0.005747572,0.07087001,-0.01307013,-0.03715493,0.08032953,-0.03313854,-0.02543114,-0.04913998,-0.013214616,-0.05044226,-0.014884712,-0.006285621,-0.003500738,0.025875244,-0.055512156,-0.12353297,-0.026768636,-0.024634466,-0.0031518312,0.030398842,0.06296134,0.03554423,-0.0191667,-0.07227106,0.0402125,0.009007577,-0.032866605,0.015153729,0.040584624,-0.030415788,-0.005436879,-0.005452758,-0.002586073,-0.00045358343,0.048132308,0.02255107,0.0059299497,-0.040221,-0.031409003,0.011795922,-0.0060388013,-0.07488807,0.0084364815,0.02320122,-0.029891329,0.03541834,0.028512953,-0.07023357,-0.021694273,-0.017583191,0.063205756,0.014351525,-0.05775791,0.08849024,0.03341988,-0.08155154,-0.0030435037,-0.05275976,0.05261986,-0.031223204,0.077451885,0.029618632,-0.07772196,0.07817653,-0.07231479,-1.2480428e-33,0.054007392,-0.03068824,0.040735897,0.027258707,0.014097918,-0.010655325,-0.10967751,-0.025785431,-0.047003865,-0.008990966,-0.115111195,-0.033509567,0.08717694,0.06793518,-0.021194939,0.025079526,0.028697096,-0.05344986,0.047083877,-0.0029352175,-0.041209206,0.07576362,-0.07082788,-0.038742166,0.021027036,0.04192535,0.058623448,-0.00899004,0.023197081,0.008545262,0.019077823,-0.049342263,-0.063415006,0.06587386,0.03462047,0.08164347,-0.09328085,-0.01834835,-0.033715896,-0.037135817,0.060512077,-0.0019505236,-0.05329,-0.016343648,0.06321827,-0.03616514,-0.039091874,0.057180747,0.055016797,0.08189226,0.07747181,0.0011384027,0.06326407,0.007418788,-0.022300834,0.05402349,-0.019184187,0.021827627,-0.021043558,0.098614134,0.034530528,0.062264264,-0.041440535,0.026403878,0.030437151,0.07642535,-0.095997155,-0.02790644,-0.07841896,0.041658446,-0.08835301,-0.07775094,0.1448228,0.042303737,0.035486467,0.01310043,-0.012757966,-0.020164207,0.012835497,0.050134562,0.016852895,-0.04089848,0.027330775,-0.041383635,-0.114437655,0.021452507,-0.034007173,-0.05483536,-0.014200728,0.023684781,0.0335883,-0.03409611,-0.03874428,-0.008715481,-0.008558125,-1.1978711e-33,0.039306097,-0.07418687,0.025509266,-0.020712713,-0.021386558,0.040515713,0.07849852,-0.01854944,0.05424345,-0.031114768,0.08844573,-0.0018978345,-0.046448644,-0.10298076,0.048291836,0.02693884,0.014657594,0.07036839,-0.032789275,0.0074240793,-0.027403759,0.12798584,-0.0036650077,0.018993499,0.08395321,-0.012256864,0.04397859,0.021633124,0.007071231,0.047174085,0.012263006,-0.0026179599,-0.05223301,-0.053219393,-0.07403507,0.03170417,-0.07238874,-0.020067481,-0.05109875,-0.003923202,-0.054442525,0.0043019596,0.081664465,0.098530024,0.10111951,0.0768774,-0.041807424,-0.017327705,-0.021321649,-0.0094443085,-0.024845768,-0.009914363,-0.030982656,0.036957152,0.06148532,0.060819782,0.014325445,-0.01717315,-0.038103823,-0.036388256,-0.022949532,0.00038605457,0.074780636,-0.09285192,0.03572882,-0.0044555464,-0.06638231,0.006308351,0.017010204,-0.009732637,0.10326948,0.0075663384,-0.07794122,0.0026749396,-0.030617826,-0.025641885,-0.10042498,-0.085898265,-0.021752603,-0.030908903,0.016863927,0.043564342,-0.032971937,-0.014079798,0.009610306,-0.061753836,-0.010656939,0.10818087,0.015237815,0.059610844,-0.06726755,-0.026904909,-0.05642984,0.016532809,0.06438195,-2.632628e-08,0.035863027,-0.048582155,0.07514573,-0.08212951,-0.014643999,0.03215208,0.04421987,0.10666465,-0.008871066,-0.048540194,-0.013715908,0.13737155,-0.0020688414,0.01734952,0.003024848,-0.03914532,-0.006448208,0.062983856,-0.055219702,0.00011310141,-0.06507412,-0.04113092,-0.05883691,0.0346466,-0.022449842,-0.08163233,0.049892582,0.048656896,0.034772865,-0.038214345,0.06517792,0.01317161,-0.0107785165,-0.0787339,-0.09151996,0.040285647,-0.04728433,-0.027329907,-0.018290224,0.042843923,0.023892822,-0.05886595,-0.023455588,0.033517532,-0.041983888,-0.020121597,-0.008064105,0.0075971973,-0.02020562,0.07721847,0.09130938,-0.028571725,-0.07654477,0.0072498545,-0.06329427,-0.0026833822,0.008755609,-0.023447167,0.06336091,-0.023166817,0.014294251,-0.005711961,0.18020806,-0.019083891 +1.1.1.121,"Acts on D-glucose, 2-deoxy- and 6-deoxy-D-glucose, D-galactose, 6-deoxy-D-galactose, 2-deoxy-L-arabinose and D-xylose.",384,1.0,-0.045298424,-0.11430771,0.01770932,-0.0075164395,0.0006648486,0.04497288,0.062139384,-0.041502267,0.03253246,0.09406854,0.025863558,-0.008265107,-0.1199527,0.006516659,0.0103118615,0.051829364,-0.050935674,0.04898085,-0.019488776,0.037991263,0.15139501,-0.013418475,0.028178787,-0.00204336,0.07653702,-0.031440403,0.03313392,-0.011796666,-0.035407193,-0.11516919,-0.022159455,-0.015581488,0.03284343,0.01477488,0.009861026,0.10018181,0.006187182,-0.037943915,0.04617958,-0.04513225,0.09367889,-0.064647585,0.079629414,-0.023863286,-0.019226046,-0.029469216,-0.08625011,0.08377124,0.015445425,-0.010484925,0.007388293,-0.1016881,-0.11211444,0.060768016,0.06138363,0.030745491,-0.05280916,0.002076697,6.6321205e-05,-0.04207819,0.010391578,0.043392986,0.021636387,0.060430583,-0.019034395,-0.07259496,0.058633137,0.0029516248,-0.039089452,-0.05156122,-0.06912931,-0.058663927,-0.025004683,-0.05642972,0.03037067,-0.024734357,-0.05363613,-0.09388285,-0.016265528,-0.06843501,0.015739689,0.0018326855,0.10177061,0.055769026,-0.03189064,-0.040943433,0.020446949,0.02469844,-0.02667511,0.008530435,0.0059670107,-0.057261735,-0.010064593,-0.019148635,-0.031456005,-0.019964958,0.059128914,0.0064348187,0.08187708,-0.01911956,-0.0051331124,0.020122819,0.0051259897,-0.06878433,-0.027593967,0.039923023,-0.05657407,0.034088403,0.008459523,-0.030254284,-0.031040309,-0.0015229716,0.06589318,0.052252598,-0.09194501,0.044575416,0.020323338,-0.07263791,0.02081659,-0.07054721,0.027945958,-0.032361705,0.08823469,0.028670263,-0.05793211,0.10743385,-0.05854652,-8.425936e-34,0.04004686,-0.07384282,0.03411384,0.01371096,0.0021957725,0.010965886,-0.062112145,0.0145821925,-0.027845591,0.036932047,-0.10968522,-0.0090753455,0.088757366,0.094044365,-0.0059467517,0.026828282,0.031426445,-0.051122952,0.053054955,-0.0009118586,-0.031337466,0.10639513,-0.059464168,-0.0046989,0.03130322,0.032760356,-0.018035797,0.03487685,0.0037359358,-0.013583549,0.015183133,-0.06635962,-0.038030606,0.07551446,0.06863239,0.08127892,-0.07681352,0.0114355525,-0.03699813,-0.055284224,0.04417393,-0.035408497,-0.042871997,-0.053693432,0.015261663,-0.0011878479,-0.0314216,0.02750161,0.06257345,0.10780808,0.07723717,-0.0318384,0.046451017,0.01118457,-0.03528406,0.06679283,-0.03165104,0.014624117,0.006595929,0.070151135,-0.00096779334,0.023280146,-0.025808966,0.0005898796,0.06600899,0.063205294,-0.09594071,-0.031033263,-0.08168486,0.029772522,-0.10390975,-0.06303259,0.099299684,-0.0027437196,0.056514297,0.028453086,-0.024985066,-0.011496848,-0.025974035,0.042171456,0.038055364,-0.03618936,0.011518394,-0.06727528,-0.12710364,0.059583925,-0.046109844,-0.069846496,-0.041262086,0.02884295,-0.03586012,-0.0018401515,-0.04881412,-0.004001333,0.063283265,-2.2871814e-33,0.023414016,-0.029095268,0.0737431,-0.020094294,-0.022300154,0.046621952,0.057746157,-0.07301478,0.06700686,-0.015444348,0.05184693,0.015004632,-0.060441755,-0.08023076,0.009811905,0.036047574,-0.031715035,0.06896247,-0.04704227,-0.0032650442,-0.039178077,0.13018468,-0.028669303,0.027178993,0.063306876,-0.000200088,0.062364932,0.034935974,0.04028283,0.020707928,0.05158107,-0.03365925,0.0020415196,-0.0064104814,-0.055995412,-0.0017052189,-0.06706268,0.0066693346,-0.069615915,0.025889995,-0.011931421,0.033177104,0.079687014,0.088597275,0.096391596,0.07248982,-0.076426074,-0.0073361723,-0.03441469,0.0046775225,-0.03368407,0.009880254,-0.023585469,0.00929054,0.057561804,0.07370763,0.04415897,-0.013597284,-0.032671105,-0.05587784,-0.025621362,-0.0073159896,0.099419504,-0.069024906,0.030759597,-0.036665212,-0.05341389,-0.016864657,0.020688945,0.02120596,0.058867827,0.008731526,-0.091590114,-0.025134733,-0.03893157,-0.029949585,-0.10246276,-0.06600666,0.007440768,-0.023769569,0.044416483,0.052043185,-0.0075778514,0.0012199014,-0.018703172,-0.030292558,0.0061391555,0.06802922,0.021914262,0.034125526,-0.04798162,0.035729192,0.008701776,0.013368946,0.06348367,-3.659576e-08,0.068775296,-0.049149107,0.03403115,-0.052747495,-0.015594237,0.018085383,0.012358256,0.10259929,0.006060398,-0.008020006,-0.010128251,0.14287665,-0.012392169,0.005966597,0.028502971,-0.040869486,-0.04431976,0.049950644,-0.063503265,0.01874984,-0.053474527,-0.048048593,-0.09920467,0.049097296,-0.0014549257,-0.12176015,0.056755375,0.006596376,0.031121142,0.01725876,0.051096138,0.030490242,-0.013524587,-0.0814416,-0.08241106,0.011558633,-0.06642623,-0.054618444,-0.0012064065,0.017076138,0.051909886,-0.082479484,-0.03909798,0.024368335,-0.053097237,-0.014097307,-0.0021680964,-0.019922284,-0.026629224,0.065101855,0.036521886,-0.021298476,-0.08721516,-0.025592733,-0.07413403,0.02926035,-0.001043805,-0.007297493,0.048048683,-0.035334274,0.023758268,0.02572005,0.13644072,-0.029683603 +1.1.1.122,"Acts on L-fucose, D-arabinose and L-xylose; the animal enzyme was also shown to act on L-arabinose, and the enzyme from Pseudomonas caryophylli on L-glucose.",384,1.0,-0.050762758,-0.09538417,-0.043036874,0.022106428,0.039233048,0.117564596,-0.026120953,-0.007732926,0.04005424,0.044207547,0.040489115,-0.015490765,-0.08425134,0.07112529,-0.02156588,0.05600392,-0.063721985,0.036242213,-0.03731199,0.03142048,0.13304362,0.027457127,-0.034877546,0.0061783977,0.038284183,-0.07120931,0.03766154,-0.033731498,-0.045453355,-0.06539016,-0.063699655,-0.00011302594,0.093951635,-0.03803044,0.037965108,0.065980114,-0.0063906573,-0.077122144,0.13747038,-0.017722972,0.077452466,-0.11418144,0.05367044,-0.087930955,-0.049538657,-0.008971001,0.0033031136,0.05022297,0.051356677,-0.004240801,-0.080403864,-0.051084843,-0.0069212145,-0.0042904844,-0.05949638,-0.0054725106,0.006515225,0.026861709,-0.050384253,-0.036530815,-0.007392379,0.055092607,-0.015924165,0.07874728,-0.07248706,-0.053346276,0.039814837,-0.03689112,0.0046271845,-0.050321426,-0.0048217634,-0.045822445,0.03806189,-0.016748847,0.08070394,-0.031980973,-0.036563493,-0.06239308,-0.042293895,-0.054011777,0.040344626,-0.0021160345,0.039442267,0.026887877,-0.011288694,-0.059326522,0.012605208,0.050073545,0.035139475,0.017264528,0.04066486,-0.069477126,-0.07728208,-0.019035907,0.001612665,-0.0035634744,0.028996356,-0.03835602,0.054472376,-0.061743464,-0.021817965,-0.00038690426,-0.029300874,-0.07296686,-0.012622699,0.04518933,-0.03088167,0.026447551,0.0002738855,-0.064062655,-0.021495003,0.034307946,0.038734853,-0.011892115,-0.05119938,0.017355053,0.090520136,-0.13962665,-0.06653935,-0.040748127,0.032645002,-0.10347211,0.06919141,0.06289553,-0.028378619,0.09903344,-0.1050114,-7.579913e-34,0.059324108,-0.059370246,-0.025417827,-0.06523964,0.022712179,-0.038629666,-0.034694105,-0.02535515,-0.053447865,0.010393694,-0.029701658,-0.0015547456,0.04161138,0.060715023,-0.028097216,0.05399918,0.02254837,-0.057557557,0.037433006,-0.0051303376,0.018245328,0.046134766,-0.04030611,-0.011971766,0.014046485,0.08022382,0.050336603,-0.024421204,-0.0041646985,0.012586172,0.017135127,-0.0898312,-0.04261351,0.023588408,0.053138223,0.055725113,-0.103147976,-0.03900413,0.0010809967,0.030012429,0.074049816,0.037281692,-0.0008735535,-0.0538487,0.05635695,0.03879062,-0.061696984,0.10633295,0.05942439,0.12834261,0.11571614,-0.06315212,0.06997331,-0.015887229,0.0011879603,0.029454075,-0.049221702,-0.008865117,-0.040306613,0.06893115,0.0075930418,0.031121802,-0.027008515,0.0096331695,-0.010467859,0.011854826,-0.06196944,-0.07844731,-0.017979693,0.013373866,-0.12573983,-0.056798372,0.06872755,-0.004231877,0.0263562,-0.038166497,-0.05729249,0.020014776,-0.026153566,0.012572244,0.059220444,-0.044348843,0.040763054,-0.046752326,-0.14696059,0.011905164,-2.22181e-05,-0.047790594,-0.0707577,-0.03323484,0.03592607,-0.031222757,0.00048813797,0.05163867,0.06104426,-2.5959524e-33,0.0218496,-0.045403555,0.06658949,-0.038406353,-0.059497673,0.012261036,0.019685952,-0.039138436,0.032653917,0.003607457,0.009032395,0.0075437,0.015441221,-0.036608003,0.016767984,0.027003217,0.031982154,-0.023168989,-0.033977218,-0.0415534,-0.07831805,0.09017532,0.03722052,0.029187568,0.0946546,0.000132069,0.0141233755,0.11116975,0.015172046,0.026297173,0.022144824,0.03662729,-0.014227506,-0.04465325,0.0031084986,0.0075458083,-0.040699117,0.022849476,0.033558276,-0.019101024,0.081141606,0.028924352,0.06791418,0.038141932,0.024225093,0.061165176,-0.08093468,-0.067492574,-0.0138841625,-0.06293553,-0.0538867,0.044288114,0.0059520896,0.0012246502,0.043075778,0.08727479,-0.026045559,-0.009045649,-0.02465754,-0.03202316,-0.04008603,-0.07916752,0.03480612,-0.01769248,0.017921709,0.010531077,0.0255478,-0.025440596,0.052906785,0.018950263,0.097059205,0.07391366,-0.040067203,0.040151946,-0.105940476,0.012489901,-0.09492158,-0.08815747,-0.019341623,0.024469357,0.047025323,0.0029589818,-0.041743726,-0.050288383,0.015239004,-0.06467658,-0.033363864,0.11478809,0.0049516913,-0.0003500425,-0.0074616494,-0.036014173,0.02470515,-0.05307171,0.062436633,-3.3482046e-08,-0.0010239112,-0.02425419,0.06688557,0.0050989697,-0.034460366,0.02986144,-0.00044609333,0.03047922,0.011823156,-0.0039745932,-0.077679075,0.088093676,0.0042938828,0.04038319,0.083178714,-0.043423526,-0.07033389,0.029019296,-0.036419645,0.051022448,-0.07301108,-0.036574673,-0.1262962,0.044671725,-0.03040253,-0.071722806,0.050861824,0.019280907,0.05202884,0.021625802,-0.020265365,0.041863706,0.0070590037,-0.033145,-0.09357782,-0.0016211111,-0.06189222,-0.033805516,-0.040397327,0.021248395,0.09869768,-0.05240284,-0.03565057,0.006327377,-0.01832126,0.0013151757,0.014677806,-0.04980283,0.01211884,0.024748752,0.12653704,-0.015016107,-0.05334793,0.01764916,-0.05981904,0.014945594,-0.007924448,-0.015495309,0.037675265,-0.0015720308,-0.032322917,0.053004038,0.14507957,-0.00753948 +1.1.1.127,"The enzyme from Pseudomonas acts equally well on NAD+ or NADP+, while that from Erwinia chrysanthemi and Escherichia coli is more specific for NAD+.",384,1.0,-0.08303263,-0.04244653,-0.055974882,-0.024953397,0.030909993,0.10563045,-0.1187121,0.053598218,0.03225451,0.0087151425,-0.008594758,-0.014275843,-0.070572756,0.092651665,-0.031775255,0.009901586,-0.005622047,0.007535538,0.048504647,0.02579357,0.05312799,-0.0030535373,0.02622431,-0.006355017,0.067694046,0.050189283,-0.011064695,0.050940204,0.028917545,-0.020742647,-0.08945679,0.05395496,0.024051918,-0.094540566,-0.005547524,0.051862933,-0.037631754,-0.037716355,0.053693794,-0.022272104,-0.005587925,0.045985233,-0.048113637,0.011208989,-0.039890524,-0.06257625,0.043495335,0.051955726,0.051116038,-0.04157188,-0.08376788,0.006811814,-0.01928846,0.032616314,0.036032416,0.034921385,0.029555839,-0.041887015,-0.042129267,-0.092560485,-0.059723273,-0.078141324,0.02231327,0.03159287,0.033732254,-0.046070818,0.060118128,0.02921368,-0.03354687,-0.06333409,-0.1489576,0.024864988,0.04437907,0.04580379,0.028578104,0.0017509162,-0.070278935,-0.061107807,0.0058339117,0.009964419,0.0028342188,0.011886697,-0.070704125,0.021897392,0.060942627,0.009016119,0.0035415515,-0.0023625474,0.0058697807,0.032899346,0.016701266,-0.0009357053,-0.007947973,0.010776541,-0.115836576,0.02044974,0.0030227355,0.009360657,0.023966316,-0.08706183,0.026604151,0.053409923,-0.056662533,-0.04890448,0.050037395,-0.014110508,-0.01916915,0.10066177,-0.033858255,0.013672145,0.012160097,-0.016797353,0.021859411,-0.072580524,-0.04996145,0.08446524,0.015818736,-0.021828743,-0.09011176,-0.027327975,0.014231045,-0.07937926,0.0183547,0.030639572,-0.0056385244,0.04113998,-0.11200592,3.7389456e-33,0.09156197,0.04219235,-0.036470044,-0.015722623,0.032641433,0.011305209,-0.098534204,0.0405387,-0.01785409,-0.05466086,-0.048254147,-0.054296363,0.029377246,-0.025469678,0.02530347,0.030767405,-0.05927888,-0.06932298,-0.05830215,0.01094852,0.07090888,0.072073616,-0.016743872,0.02668617,0.08924625,0.029437264,0.0166365,0.08466835,-0.0812302,-0.019428339,0.08622981,-0.07597178,-0.1337154,0.002029647,0.12021494,0.032968275,-0.03405789,-0.0704352,-0.003506687,0.018547371,-0.1040847,0.09088109,-0.019346254,-0.022845436,0.08767931,-0.10141672,-0.047964662,0.097059935,0.033723094,0.075401254,0.016818874,-0.021489205,0.12367635,-0.023918148,-0.026423512,0.054399885,0.021471456,0.019045504,-0.036596708,0.10099133,0.008291673,0.015453664,0.0076546893,0.023489596,-0.09257155,0.03935727,-0.042043284,-0.041039575,0.06811771,0.08420345,-0.0021016258,0.06859188,0.03299967,0.06657255,0.029589023,-0.049825184,-0.00841447,0.0036846537,0.03186804,0.026091374,-0.01056069,-0.035004184,-0.021103447,-0.01335641,-0.068263784,0.03415157,-0.010203372,0.008168481,0.012849679,0.039844494,0.10295388,-0.029384017,0.037620444,-0.018780438,0.019365618,-4.9292122e-33,0.056492213,-0.043714173,0.0681387,-0.069178246,-0.07604697,0.087972485,-0.039395716,-0.11635506,-0.020289425,-0.066319205,0.026266553,0.0791353,-0.010621656,0.008484175,-0.008016162,-0.009370311,-0.01814637,-0.023898305,-0.008562534,-0.019250512,-0.006688595,0.085392095,-0.005531335,-0.039218478,0.07028366,-0.01552119,-0.084033184,0.10118104,0.0044884994,0.036033582,0.013543975,-0.011786978,-0.108131714,-0.019465523,0.02248913,0.02001374,-0.062958606,0.016175667,0.01652172,0.028683433,0.06632801,0.016816393,-0.050873507,0.06102143,-0.012868165,0.040872656,-0.10988031,-0.054039318,0.060901847,-0.07510823,0.0007351244,0.051579986,-0.032164447,-0.002502428,0.049376212,-0.005774004,0.01121214,-0.0048117614,0.0052040266,-3.791608e-05,-0.030150423,-0.04748795,-0.003268408,-0.00043264835,-0.008687198,0.0135876965,0.026834339,0.0011501752,0.05140814,-0.05461248,0.040186428,0.06577757,0.01600591,0.03783188,-0.055078987,-0.0028611503,-0.055556342,0.00077520893,-0.026083775,0.04137245,-0.0052060955,0.010893574,-0.059125848,-0.03753692,-0.061770577,0.05637699,0.006984549,0.012141313,-0.07167567,-0.008135835,0.03454508,0.07030016,0.026211191,-0.05520525,-0.04192221,-2.9021272e-08,0.053159934,-0.030449832,0.049954023,-0.08212659,0.013136476,0.04614392,-0.07041439,-0.057401247,-0.0004929317,0.034374,-0.019856233,0.12276563,0.0082316175,0.02813942,0.050329447,-0.04016802,-0.06736874,-0.035429496,-0.035310093,-0.011251566,-0.07248124,0.022965152,-0.1368905,0.0830017,0.019332638,0.002698978,0.029827036,-0.071146905,0.052822083,-0.032485988,0.00609534,-0.0018627653,0.03524777,0.01939482,-0.06554252,0.048150267,0.0114271315,0.0036415576,-0.07247715,0.06017602,0.0791662,-0.12173303,-0.06453147,0.013606394,0.027583497,0.033530105,0.051485777,-0.07324011,-0.030783096,-0.029968362,0.11158704,-0.070165455,0.062977366,-0.024040839,-0.064790614,0.048526574,-0.006879415,-0.06897024,0.0014213115,0.033555355,0.034611225,-0.035353232,0.0734618,0.030690102 +1.1.1.132,Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate.,384,0.99999994,-0.105487,-0.025832685,0.011925237,-0.019572046,0.017106974,-0.057485368,0.016168335,0.04825294,0.036189497,0.032780565,0.06954533,-0.0010836303,-0.03608937,0.05375983,0.010543199,0.0049724164,-0.05459534,0.059508488,0.08884882,-0.0019571553,0.0337681,-0.013624889,-0.019326841,-0.049707476,0.07908724,0.08954348,0.05228935,0.048389833,0.028648656,-0.061672926,-0.04312605,0.038672365,-0.02308178,-0.05186999,-0.01727033,0.14653689,-0.07445374,-0.028782802,0.022244494,-0.012221256,0.099221066,0.011892611,-0.017673597,0.009939421,-0.03246329,-0.053347196,0.0043350644,0.020709278,-0.036097225,0.009735956,0.036432385,-0.011209465,-0.030699,-0.012473393,0.006051511,0.021178272,-0.07088704,0.09001578,-0.026335374,0.0022657574,-0.004442505,-0.025572965,-0.059929475,0.017207956,0.12507488,-0.030118324,0.040498525,-0.019105498,0.015087336,-0.022632904,-0.048889562,0.014598888,0.023539167,-0.040542442,0.021132762,0.07721118,-0.01930579,0.005621588,0.032054044,-0.021438934,0.043793235,0.015715932,0.038981535,0.007111938,0.032717086,0.021344487,-0.016355896,-0.046039943,-0.024945416,-0.0027586687,0.0013906959,-0.017382221,-0.10837995,0.008990665,-0.05351865,0.059411325,-0.0067541315,0.09796547,-0.043582097,0.005742164,0.016685454,0.07495461,-0.08533976,-0.035368983,0.002311123,-0.017204572,0.02466831,-0.012535384,-0.035550248,0.016466994,-0.069149375,-0.011702683,0.013538617,0.001380676,-0.07815021,0.05753529,0.018143373,-0.015088889,0.024648478,-0.09704929,0.018588552,-0.040798742,-0.05580954,0.053568065,-0.05168796,0.06519772,-0.031951208,8.557345e-34,0.08172954,0.009668641,0.01067946,-0.011980594,0.0021645334,-0.040324554,-0.045395948,-0.033368714,-0.08759594,0.018560698,-0.0732694,-0.03178147,0.10686807,0.00717429,-0.056525536,-0.036686577,-0.12278648,0.016392358,0.10570626,0.0305817,0.025874915,0.04540574,-0.09383227,0.006094856,-0.033428825,-0.038118757,-0.10039985,0.053999353,0.011911995,-0.015307589,0.033737827,-0.050495103,-0.09001224,-0.0030916766,0.06845402,-0.030210918,-0.08160884,-0.044112306,0.0038850782,-0.0012709965,-0.034004726,-0.0660472,-0.016071444,0.010302082,0.03644259,-0.056694936,-0.016193671,-0.0002352981,-0.0043149246,-0.0023409936,0.042591736,-0.06876128,0.08604224,-0.095553644,-0.014917159,-0.011499355,-0.012854,-0.022475353,0.008863038,0.1075698,0.01704962,0.022227906,-0.06681546,0.020860584,0.06895763,0.06330292,-0.07843801,-0.027182879,0.009875293,0.039859325,0.011981943,0.010962288,-0.0064376583,-0.016152704,-0.01998232,0.026450584,-0.03562131,0.048040878,0.06885976,0.043920226,0.0627309,-0.09824742,-0.039473604,-0.049735963,-0.0531543,0.0033054475,0.016945256,-0.13314395,0.016891811,0.0022224018,0.03242852,-0.021945653,-0.020674545,-0.05662441,0.07045878,-3.3798717e-33,0.05323855,-0.021877028,-0.061413933,-0.090462774,-0.11016665,0.014621875,0.07970482,-0.050984815,0.04564898,0.03494114,0.0410742,0.019995842,-0.06491376,-0.007919632,-0.088895686,0.050969042,-0.057573024,0.017681768,0.014028473,0.016907604,-0.022607261,0.20050183,0.058819734,0.14491755,-0.011655295,-0.0628905,0.024496773,0.02393099,0.015635567,0.053821847,-0.070247136,-0.028513102,-0.032580443,0.030441761,-0.03207265,0.047890134,-0.017422453,-0.028709231,0.0047937087,-0.005210996,-0.002632323,0.009798418,0.074489854,0.076194614,0.060007613,0.033015586,-0.044602755,0.016485542,-0.098441966,-0.056755725,-0.054176874,0.040946957,-0.010194018,0.04270129,0.018250246,0.090086386,0.017003968,-0.021578442,0.036372628,-0.041674353,0.0221948,-0.076780856,-0.01790169,-0.064403124,0.034553446,0.07208099,-0.053205788,0.025889618,0.0272794,-0.002304421,0.06170501,0.013088176,-0.021500343,-0.009375663,-0.052767072,-0.06310281,0.011721193,0.010055023,-0.008053857,-0.038251564,0.017366225,0.04443277,-0.066532016,-0.078323714,0.009455585,-0.05665386,-0.030178672,0.058663104,-0.026808392,0.036957733,0.0057617817,-0.011731893,0.005437362,0.101356655,0.054654967,-2.4298968e-08,0.00010364068,0.0058920383,0.020884912,-0.057679493,-0.014688896,0.019182874,0.08540406,-0.027473185,0.023757847,-0.016614906,-0.011910815,0.08663178,0.067618266,-0.0075866077,0.12877983,0.077482745,-0.055585735,0.04247452,-0.07116195,-0.040829614,0.0047602137,-0.045523997,-0.046530906,0.105032735,0.045436338,-0.04576944,0.08646719,0.0059577753,0.033205926,-0.015720958,0.03669627,0.012925037,-0.010431802,-0.07352118,0.012356269,0.0441724,-0.031134786,-0.026182689,-0.04102517,0.06159242,-0.08673731,-0.04746333,-0.02172929,0.03184603,-0.010141725,0.069823116,0.012683857,0.05256968,-0.0034820703,0.076777615,0.047348596,-0.07576988,0.008528299,-0.06214619,-0.07698166,-0.046898592,-0.06283203,0.016942035,0.053197328,-0.028503453,-0.010844978,0.083714075,0.19365892,-0.0522721 +1.1.1.133,"In the reverse direction, reduction on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyses epimerization at C-3 and C-5; the complex has been referred to as dTDP-L-rhamnose synthase.",384,1.0,-0.039435554,0.0058461763,-0.020689672,-0.016242774,0.048344824,0.046125628,-0.023537712,-4.2077256e-05,-0.013086686,0.07822908,0.031077325,-0.017465496,-0.06222845,0.01585436,-0.03254356,0.017320283,-0.107184075,0.022451526,-0.014761074,-0.038189862,0.08509503,-0.10791369,0.012069983,-0.011763002,0.07561766,0.022996964,0.09881871,-0.038680952,0.050232686,-0.09945511,-0.017929897,-0.008980105,-0.007916659,-0.10090135,-0.0109239435,0.047254004,0.007524272,-0.029877326,0.036102813,0.02024086,0.063034184,0.04318294,-0.051790547,-0.012175955,-0.04588848,-0.02343357,-0.065566435,0.02972679,0.0035551398,-0.041347135,-0.01835014,-0.03363983,-0.04528699,0.014883406,-0.033296455,0.037740584,-0.056288935,0.06656345,0.0024702807,0.03492446,0.11653847,0.0140686985,-0.059635624,-0.018403811,0.05635027,-0.03355124,0.037388273,-0.052993014,-0.035565864,0.050205994,-0.05385476,-0.016225958,-0.034174494,0.0067800046,0.072876334,-0.005037339,-0.012208879,-0.02870586,0.0077072293,-0.009309698,0.07025213,0.047763698,0.04061494,0.037061747,-0.04913343,0.012219751,-0.00854542,0.0052911732,0.09503257,-0.011251911,0.0039299843,-0.051005263,-0.13097692,0.0035620974,-0.025308615,0.018895667,0.03693156,0.09830547,0.085645795,-0.06521777,0.025658937,0.042708162,-0.031193215,-0.03564667,-0.042893715,0.06159955,-0.056797985,0.080730624,-0.013473749,-0.004827259,-0.026027707,0.06438736,0.050698828,0.026515372,-0.06699842,0.071078815,-0.057784107,-0.06360798,-0.030724427,-0.050536253,0.008675774,0.036482815,0.0053298804,0.086302556,0.015662968,-0.021112155,-0.07414674,1.0112542e-33,0.03253754,0.11873719,-0.0140595725,-0.034257084,0.04137874,-0.03588553,-0.08606481,0.005527486,-0.0869694,0.04874272,-0.07820381,-0.055655994,-0.019443361,0.0107192695,-0.084046185,-0.093186535,0.0536208,0.06966724,-0.005971395,-0.013272903,-0.006111766,0.08669967,-0.08841438,-0.040737905,0.0019578242,0.09921782,0.01809294,0.017893234,0.060884383,-0.015786875,-0.03138427,-0.0034456241,-0.044868894,-0.01084591,0.076552615,0.015088442,-0.025313133,-0.03939211,-0.00279666,0.061290234,0.026018992,0.02646991,-0.025178831,-0.01646148,0.014892343,-0.0791444,-0.018204354,-0.012154371,0.016758405,0.04106621,0.060879488,0.0019436199,0.06923175,-0.03635029,-0.018237807,-0.01277612,-0.030396104,0.0014717694,0.05911072,0.025547592,0.03886718,0.025247402,-0.084391065,0.031272974,0.0051387,0.0123980185,0.0032459493,-0.06385465,-0.015492596,0.052725412,-0.098747596,-0.03452617,0.112395816,-0.009515617,0.12288228,-0.00071363035,-0.10172404,0.040747322,0.02495684,-0.025871234,-0.06435131,0.011536876,-0.044603065,-0.069625534,-0.006572096,-0.09527539,-0.029361596,-0.039024215,-0.04118589,0.039035417,-0.005763899,-0.095822886,0.0030912287,0.047254954,0.014536036,-3.745593e-33,0.04481636,-0.12818466,0.03419812,-0.0698194,-0.1123595,0.048960697,0.080657445,-0.019127792,0.03697464,-0.020220663,0.122582145,-0.018698975,-0.044572916,0.006258735,0.005262296,0.049498204,0.013608669,0.04696041,-0.03146123,-0.060820177,-0.031502284,0.016940469,-0.02942462,0.06875566,0.03525421,0.026977776,0.050929736,0.10387517,0.0831505,0.02358872,-0.047183305,-0.10917129,-0.024899578,-0.0002104741,-0.044325326,0.10995875,-0.07477036,0.026785351,0.008297519,0.050065488,0.018731091,-0.016052905,-0.008452449,0.041517287,0.040374912,0.07566548,-0.12896796,0.0786714,0.053414136,-0.03268109,-0.009777147,0.031142805,-0.0072782105,-0.020393264,0.014054774,0.08700437,0.043020763,-0.049119134,-0.0017455878,-0.003810109,-0.0570788,-0.053909212,0.07398429,0.03159376,0.022372648,0.09809273,-0.043818034,0.034025885,0.06922393,-0.056470912,0.027477391,0.04084105,-0.008411773,0.017417897,-0.014023687,-0.0898306,-0.02629717,-0.03715801,-0.021794276,-0.06019486,0.030703077,-0.021107754,-0.012747499,-0.044129137,-0.052451722,-0.03235733,-0.0418752,0.06565307,0.034889426,0.04729571,0.029728433,0.041555982,-0.0025334586,0.07317268,0.13031411,-3.8167105e-08,0.043785226,-0.052479558,0.048107557,-0.0625873,-0.0062606977,-0.009277262,-0.04828017,-0.011360775,0.070821196,-0.06550331,-0.022139352,0.039796725,0.020169297,-0.00013460185,0.05948804,-0.021479284,-0.04691053,-0.006974674,-0.032869037,-0.021673804,-0.052365378,-0.03267745,-0.03847694,0.013390926,0.042574856,-0.0543045,0.05436126,0.064513005,-0.06623403,0.034329113,0.0065791984,0.074281186,-0.03325868,0.08617811,-0.040832777,-0.021415032,-0.0059438767,-0.014370978,-0.06586474,0.0016966577,0.016302047,-0.054530364,-0.055837207,0.04403747,0.023590678,0.024816208,0.056738053,-0.018122265,0.061186835,0.030587278,-0.053934954,0.009544324,-0.050141875,-0.104137026,-0.04220933,-0.008595113,-0.06733465,-0.017410463,-0.0057941154,-0.091901205,-0.014308656,0.0023172684,0.16918068,-0.08248785 +1.1.1.134,Oxidation on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyses epimerization at C-3 and C-5.,384,1.0,-0.026460314,-0.024137367,-0.020768605,0.022919407,0.1108269,0.06199412,0.0003736524,-0.039723817,0.016707417,0.060139105,0.00873807,-0.011334859,-0.060324695,0.019774856,-0.03144534,0.0032962041,-0.11675879,-0.016595334,-0.04299513,-0.044184234,0.07193494,-0.16326952,0.07705812,-0.04356909,0.078426935,0.02284791,0.04112973,-0.016791493,0.00588965,-0.108835556,-0.020224141,-0.0038846605,-0.00355817,-0.05955419,-0.0021150655,0.05324812,-0.03609843,-0.06588549,0.0049846577,-0.010759963,0.025764318,0.060376577,-0.07871801,0.06374231,-0.05617743,-0.053882718,0.04860073,0.03096944,0.015208107,-0.033919353,-0.010050374,-0.037403572,-0.039603494,-0.018548526,-0.06682278,0.054697115,-0.00073057855,0.01302104,0.034850713,-0.017532008,0.06636479,-0.0049745888,-0.006398532,0.025555644,-0.0037955074,-0.052205022,0.061461244,-0.079988234,-0.0851581,0.029332222,-0.059967533,-0.0062343613,-0.035621785,0.014740872,0.04613776,-0.022497244,-0.0029485764,-0.05466906,0.00019399422,-0.014037037,0.00018353718,-0.0016384722,0.09330566,0.06424999,-0.016488798,0.0035656374,-0.02435089,-0.073453456,0.05258264,0.012940294,0.025722804,-0.0055087614,-0.09529002,-0.0085944785,0.0009854712,0.022589032,0.056251854,0.093425184,0.035675935,-0.048791926,0.044304676,0.042647075,-0.07147781,0.036755655,0.027534949,0.078555994,-0.06317505,0.109256506,-0.04491305,0.007236955,0.0076588728,0.01286728,0.059209652,-0.0032667783,-0.022223458,0.10796393,-0.027858611,-0.07132698,-0.018480526,-0.022247223,-0.027058667,0.04573942,0.010680917,0.06048615,-0.054366246,-0.024205666,-0.03242618,-1.3110228e-34,-0.0062244358,0.06877704,0.013644949,-0.013569004,-0.009557572,-0.039565314,-0.06742799,-0.010293307,-0.059627578,0.030075874,-0.081930906,-0.039854426,0.048624314,-0.012741796,-0.016402945,-0.040972203,0.027461438,-0.005635602,0.013909325,0.008774746,0.0009952327,0.0012543099,-0.06853226,-0.05303311,0.009535427,0.074323535,-0.004298533,0.024096834,0.014652164,-0.017541096,0.0022411214,0.02902654,-0.025808232,-0.055368185,0.08974148,0.014582899,0.035708997,0.04281409,-0.03474988,0.060845144,0.031575464,0.03985785,0.023761777,-0.029684486,0.012530513,-0.07016843,-0.051087175,0.09942935,0.040469326,0.042161215,0.041666772,0.009689375,0.11376467,-0.0016918947,-0.0058365962,0.088009305,0.018967781,-0.048715465,0.054109503,-0.007512278,0.042690773,0.0500417,-0.08095061,0.043965276,0.016342051,0.06620551,-0.020418197,-0.0012383726,-0.0399234,0.11522972,-0.11480809,0.021803228,0.11962763,-0.0064150793,0.04334175,0.07101425,-0.11257661,0.045946237,0.018093916,-0.012628211,-0.017037911,-0.061243568,-0.04806927,-0.053575035,-0.047216717,-0.04317543,-0.030010875,-0.05784648,-0.0045491923,0.10138422,0.10226971,-0.088110805,0.045267295,0.019410491,-0.049268275,-3.0661688e-33,0.0991523,-0.09388201,0.061144367,-0.064696565,-0.08495289,0.06411487,0.038524594,-0.039636236,-0.020974033,-0.0010771181,0.050979346,0.04729642,-0.059576225,0.010973154,0.025929838,0.081983306,-0.048287544,0.07586357,0.014190499,-0.020166757,0.021042284,0.00604251,-0.08053641,0.039565973,0.056972545,0.018176926,0.03047101,0.014414702,0.07641784,-0.018315136,-0.06486163,-0.117874384,0.027464012,-0.018205456,0.0008583406,0.063599154,-0.106147714,0.008135478,0.025721563,0.06163608,0.00072116265,0.004327514,-0.04527828,0.054244928,0.032248594,0.07526706,-0.14100835,0.05986258,0.024102867,-0.025436547,-0.020716613,0.009758258,-0.035923187,-0.030945582,0.02212482,0.12282111,0.032461647,-0.048009817,-0.015376472,0.0017337753,-0.024267081,0.0071916888,0.08664669,-7.7314035e-05,0.043589957,0.010823154,-0.09945079,0.028543457,0.019461999,-0.04993233,-0.060336754,-0.032355063,-0.008445853,-0.006391021,-0.034237593,-0.01156224,-0.024732996,-0.0021476662,-0.019235786,0.008220194,-0.012049879,0.02244903,-0.024955345,-0.046230685,-0.05685624,-0.05664282,-0.012478166,0.047105532,0.10277765,0.00828129,0.0009887964,0.02116396,0.027831811,0.0036333583,0.11863023,-3.087044e-08,0.010410971,0.0004442562,0.11834504,-0.024038602,-0.043410193,0.04394012,0.008202072,-0.067202985,0.069525264,-0.05513925,-0.023016745,0.093943864,0.024666626,-0.04232189,0.021690547,-0.03528911,-0.0631208,-0.07432875,-0.0046024104,-0.02356914,-0.14363225,-0.0018697164,0.016245326,0.01300368,0.017374517,-0.10800356,0.012886598,0.0464621,-0.10467437,0.03814436,-0.060097076,0.05865174,0.0051276586,0.020795148,-0.038747262,-0.004459933,-0.008170389,-0.027423805,-0.04436556,0.0040071094,-0.0009585439,-0.09535592,-0.05394241,-0.003547268,0.046361264,0.015698439,0.026771436,-0.026052007,0.04119018,0.011700435,-0.06315786,-0.00029515362,-0.10015379,-0.031871676,0.0032883189,0.009615525,-0.057342615,-0.012499424,0.019413332,-0.087601446,0.0044948305,0.015861098,0.12453709,-0.10221008 +1.1.1.136,"This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.",384,1.0,-0.041454427,-0.08306447,-0.090965,-0.09913893,-0.052428547,0.024788832,-0.021487588,0.0132256625,-0.006196312,0.12115115,-0.03826668,-0.0571331,-0.040969964,-0.03828363,-0.005963337,0.07293111,-0.055781037,-0.036345072,-0.03989014,0.0054169386,0.07349043,0.051834628,0.06143233,0.010220806,0.009627656,0.02803658,0.10270992,-0.03552659,-0.027750548,-0.09733908,-0.059792057,-0.06002899,0.024072206,-0.07790543,0.08809041,0.042220887,0.011200053,0.028668325,0.019052807,0.0071769203,0.011749251,-0.053935155,-0.033030264,0.025279071,0.017419087,-0.008666362,-0.06918295,0.076240286,0.081637956,0.00858533,0.011350435,-0.029834243,-0.016267205,0.054484535,0.0057346267,0.04666623,-0.004558488,0.049961116,-0.010233126,0.0389879,-0.01288525,0.021215986,0.08449364,-0.0221547,0.08536394,-0.018194646,0.025412632,-0.08813286,0.021554807,-0.0065775,-0.03979546,-0.10527022,-0.009057594,0.022627225,0.03372395,0.023851806,0.06896298,-0.0119831925,0.054473348,-0.10306892,0.06068184,-0.025987372,0.022441424,0.18439326,-0.03798142,-0.00026464876,-0.04821827,-0.10340196,0.03472101,0.03508815,-0.043354705,-0.011217589,-0.0026591027,-0.0067051193,-0.10516924,-0.0067109196,-0.029254591,0.016796993,0.077802666,0.01874436,-0.009018424,0.036141,-0.09093501,-0.07929128,-0.073160626,-0.039022326,-0.03615424,-0.074859105,-0.003178393,0.029460138,0.054659314,0.02062507,0.0044051246,0.033034988,-0.09016728,0.034786955,0.03601539,-0.07723682,0.01114766,-0.090062775,0.013552494,-0.022614324,0.04574678,0.027592327,-0.060977183,-0.016280748,-0.008045535,-1.3858764e-33,0.016049111,-0.045173764,-0.008042043,-0.014594185,0.047500517,-0.055505022,-0.07971184,-0.06115876,-0.098087855,-0.008589359,-0.07344591,-0.11971905,0.01816739,0.09818429,-0.057204597,0.048827384,-0.017764667,-0.01274329,-0.01779307,-0.03272827,0.0013503822,0.110374205,0.019860843,0.016872302,0.08653267,0.07312624,-0.029955326,0.07248744,0.10049911,-0.021447306,0.039183836,-0.02801054,-0.07855362,-0.05633507,0.010179318,0.019274227,-0.04835652,-0.025311314,0.0021186597,0.07223835,0.014812692,-0.032417033,-0.035795514,-0.03533259,0.0077234963,0.02988419,-0.023992993,-0.0043666284,0.05271563,-0.029967062,0.039111603,-0.029491542,0.10263819,0.031583317,0.0059923176,-0.019560553,-0.07895043,-0.06173218,0.060427118,0.09696405,0.026824955,0.035166584,0.0038277558,0.037143584,-0.018615538,-0.016509425,-0.026483469,0.035014797,0.037247956,-0.039358635,0.019751597,-0.04448035,0.069617614,0.023133842,0.010198806,-0.035475954,-0.019500833,0.028262686,0.009760295,-0.05237401,0.031927973,-0.03903662,0.03509794,0.024337918,-0.04530262,0.019895585,-0.0093140155,-0.08714016,-0.04274933,-0.009101784,-0.046291996,-0.010354821,-0.06352391,0.08520448,-0.014731165,-2.4979325e-33,0.051495142,-0.063213035,0.06805836,-0.05949024,0.0008682102,0.0113233775,0.06763509,0.009843973,0.050960813,0.044905435,0.07283842,-0.029976368,-0.0063997633,-0.011755107,0.025685018,0.009336052,-0.045514688,0.053295128,-0.05345025,-0.010073378,0.018378485,0.060032737,0.006158134,0.08079851,0.02142755,-0.04082123,-0.018723786,0.1077841,-0.022502344,0.048115134,-0.024288563,0.018734345,-0.0377256,-0.031528007,-0.00017364153,0.06525846,-0.0041855974,0.013004797,-0.07054951,0.017479995,-0.10336357,0.044751775,0.0048114555,-0.05415102,0.034098696,0.048573654,-0.049178496,0.053744495,-0.07553109,-0.011592282,0.07916639,-0.016593307,0.14450152,0.036691736,0.025395846,0.09842099,-0.0011754929,0.0314029,0.07794784,0.017693723,-0.028157884,-0.09232099,0.0791786,0.0144538395,0.087430574,0.09700887,-0.024611773,-0.024634412,0.03986288,-0.008082606,0.009535782,0.05778651,0.0018944732,0.09247445,-0.033734456,-0.018257666,-0.12890102,-0.049431313,0.003628899,0.011600547,-0.027960943,0.0014997226,0.034571387,0.01566498,-0.030080361,-0.009349805,0.06179892,0.06085339,-0.017421402,0.06322902,-0.015048251,-0.023070082,-0.116606265,0.043906625,0.03877025,-3.685695e-08,0.081069276,-0.045920003,0.02581596,-0.06824003,0.008223876,-0.050297096,0.013564301,0.014706857,0.036548495,-0.070249155,-0.016109046,0.08261505,0.038989656,0.011796767,0.00027088664,0.000358923,0.02774538,0.044879712,-0.057491697,-0.029865619,-0.055359412,0.0066008326,-0.08197266,-0.048650123,0.039741915,-0.06099597,-0.0008698844,0.029627789,-0.012695166,0.008030098,-0.006014935,0.0054525076,0.024725484,-0.098049164,-0.029415565,0.010160025,-0.060286965,-0.09444065,-0.025880156,0.039925892,-0.0019618256,-0.024762552,0.0748838,-0.004841889,-0.03249919,-0.04495751,-0.053593766,0.046187844,-0.02488655,0.028177634,0.020109875,0.007267696,-0.05549173,-0.079037875,-0.090839274,-0.04842898,-0.08877624,-0.018398814,-0.011603212,-0.008265803,-0.019067653,-0.0012711175,0.14864527,-0.07471796 +1.1.1.137,"The enzyme, characterized from the bacterium Lactobacillus plantarum, can use both NAD+ and NADP+ as electron acceptor [cf. EC 1.1.1.405, ribitol-5-phosphate 2-dehydrogenase (NADP+)].",384,1.0,-0.06784816,0.005324374,-0.059127085,-0.023220912,-0.008576965,0.047307972,-0.09654579,0.055134464,0.007301024,0.018663215,0.017513746,-0.0300616,-0.07076364,0.05112297,-0.017175267,0.0044889716,-0.042101886,0.03430205,0.07665476,0.010926189,0.007848144,0.04438821,-0.024250505,-0.084087685,0.12554021,0.030131478,0.023193134,0.018973485,-0.023332005,-0.04608032,0.0058651646,-0.025488857,-0.024899447,-0.037315305,-0.073592775,0.059913762,-0.06190792,-0.068597004,0.02268022,0.0024155814,0.016406871,0.021602927,-0.03017406,-0.018393114,-0.058543865,-0.04332498,0.05587548,0.0995868,0.041126657,-0.054280218,-0.0397647,0.0069975043,0.014625001,-0.0023778125,-0.004608395,-0.027935835,0.06320667,-0.05516837,-0.025783533,-0.08889615,-0.033874396,-0.059561756,0.009976137,0.049913637,0.03222397,-0.052152485,0.031957112,-0.038972717,-0.046032924,-0.026952287,-0.13083345,-0.030449806,0.03953167,0.006136377,-0.050329722,0.047782943,-0.05283803,-0.023218751,0.117147975,0.035406634,-0.024431719,-0.019243075,-0.07123017,0.09610659,0.06468985,0.059141554,0.014385471,0.049329717,-0.03541421,-0.011584151,-0.014085777,-0.03346603,0.014181364,-0.00048129767,-0.13273342,0.011044234,0.04019893,0.0219379,-0.009877732,-0.085301414,0.0062591946,0.081335835,-0.028187748,-0.064003535,-0.06918114,-0.0026131994,-0.029301869,0.09546838,0.007240586,-0.026721066,-0.02118465,-0.02317334,-0.03184095,-0.031507034,-0.008203626,0.09282363,0.016261972,-0.10902259,-0.037846457,-0.049868934,-0.020292008,-0.02797669,0.013094848,0.034255296,-0.0030993822,0.012040955,-0.072704844,1.482538e-34,0.050507978,0.010293539,0.0019458319,-0.034390908,0.05928056,0.042792644,-0.08208583,0.04595499,-0.04539353,-0.07632999,-0.07396135,-0.11199552,0.08016302,-0.011552336,0.027878607,0.07904575,-0.040358342,-0.03595596,0.027303396,0.05137038,0.042261742,0.07505537,0.010189466,0.08019899,0.055557106,0.06494572,0.023550726,0.06413698,-0.020417612,-0.023353916,0.12382941,-0.09276732,-0.13163298,0.04842879,0.06107162,0.0039496743,-0.023983981,-0.008118124,0.010903589,-0.0015517974,-0.07425658,0.083530985,-0.005720718,-0.00050307764,0.03801681,-0.04768301,0.006667205,0.02431459,0.019919273,0.07304376,0.060123257,0.018537363,0.049161825,-0.077818386,-0.011751905,0.09666064,-0.03172044,0.09866718,-0.020206653,0.06291874,0.016104251,0.04521122,-0.0071629416,0.057017166,-0.05118837,0.0715212,-0.019809939,-0.06648689,0.071124114,0.05974663,-0.010102052,0.024565397,0.03867132,0.020920776,0.023204394,-0.00028831666,-0.0073036314,-0.035641156,0.04245893,0.008531592,-0.0068617156,-0.09652539,-0.021760866,-0.051504303,-0.032105617,0.007322084,-0.027189508,-0.019355575,0.03390979,0.029238528,0.094666444,-0.044755336,-0.016885217,-0.04779407,0.027105363,-2.3969142e-33,0.07952466,-0.015769785,0.049384743,-0.08060517,-0.017578602,0.0763522,0.014749634,-0.12377747,0.01934359,-0.05349255,0.06560856,0.06811526,0.06315972,-0.004321052,0.026335094,-0.002443148,-0.055740792,0.0364412,-0.00569279,0.0069310023,0.040617965,0.10499647,0.032440476,-0.0760246,0.07000678,-0.027212808,-0.091264516,0.025217066,0.046185862,-0.04410623,-0.025833018,0.054454405,-0.02838275,-0.056432765,-0.008893425,0.0030241988,-0.07398779,0.018946562,0.04815122,0.03886044,-0.0057227057,0.014862063,-0.035107106,0.061959688,0.010407291,0.0032723134,-0.09710828,-0.03711759,0.027561937,-0.05224965,-0.009014612,0.046792936,-0.03131559,-0.0130132595,0.071215004,0.06625093,0.013335399,0.04199858,0.09586467,-0.0003678035,-0.0560104,-0.077323094,0.079496235,-0.018213874,0.008961013,0.017664861,-0.020917319,-0.00028690315,0.017303547,-0.061574835,0.04681458,0.036793184,0.028413847,0.08633271,-0.04498552,-0.02552989,-0.08726514,0.0032993897,-0.051400784,-0.007517103,-0.013664262,0.029741775,-0.021132229,-0.017156804,0.045605052,-0.032851927,0.00022194034,0.062299874,-0.040552326,-0.010249021,-0.024398308,0.08370157,-0.00018230508,0.034673925,0.030423507,-3.4205026e-08,0.0015730258,-0.028832525,0.031659614,-0.08754265,0.028969651,0.0046524014,-0.04165699,-0.057852432,0.068582855,-0.01735625,0.03476294,0.18006654,-0.0093457345,0.018028408,0.050509416,-0.03656411,-0.014917139,-0.08434593,-0.022250298,0.011473754,-0.05980135,-0.017550308,-0.12005039,0.074313626,0.03558216,-0.021513758,-0.023127746,-0.03454561,0.05706328,-0.04325343,-0.016669773,0.051072214,0.07232628,-0.045837764,-0.049236566,0.037312496,-0.061863128,0.0022343753,-0.016060902,0.087929375,0.035013653,-0.10435067,-0.014552605,0.017003477,-0.011606788,0.07626922,0.04424861,-0.057859343,-0.089821264,0.0067371936,0.02536147,-0.04683736,0.02929546,-0.06536765,-0.061404884,0.0849363,-0.033312764,-0.09208895,-0.01815915,-0.022528827,0.039093863,-0.016543359,0.10976251,-0.019737154 +1.1.1.141,"Acts on prostaglandin E2, F2alpha and B1, but not on prostaglandin D2. cf. EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).",384,1.0,-0.086310945,-0.03328249,-0.0292421,-0.1037782,0.06600244,0.0466402,-0.04776708,0.06460057,0.026261348,0.02376077,-0.019456783,-0.047585357,-0.07474604,0.041122064,-0.014996303,0.027557509,-0.032774676,-0.020558568,-0.009442028,-0.02834379,0.012920135,0.0075164596,0.021164166,-0.039735135,0.04259197,0.010335919,0.0124284895,0.079077564,-0.008273711,-0.052170772,0.026588662,-0.060280282,-0.06563175,0.015480006,0.011439374,0.088091366,-0.031565536,-0.027945625,-0.0046737134,0.012948755,0.05582526,-0.016959563,-0.091877565,-0.041886974,-0.032624308,-0.01937024,-0.022906324,0.097435005,-0.0070025628,0.033838566,-0.013546564,-0.026923807,-0.0019422813,0.04062898,0.029444838,-0.04111295,-0.006072473,0.021909177,-0.01112577,-0.0007408178,-0.08480711,-0.09952945,0.02859021,0.03705906,0.040535673,-0.02398197,0.036552597,-0.041042086,-0.08821486,-0.008925174,-0.07490448,0.021888148,0.020897333,0.01948395,-0.0066987583,0.05637818,-0.12786205,-0.08421237,-0.030616393,-0.10618399,0.051529042,0.0008107321,0.01455548,0.06940101,0.030344956,-0.03343303,-0.03439585,-0.021665167,-0.070725895,0.060807217,0.040001508,-0.031207673,0.03341031,0.09148709,-0.030085726,0.03188699,0.02843561,0.0132823875,-0.013826429,-0.04979952,-0.12223297,0.07522487,-0.068073235,-0.058516536,-0.023253886,0.018657826,-0.027824877,0.06449405,-0.03855798,-0.018902445,0.05892552,-0.053955093,0.05855117,0.038462628,-0.01882034,0.06407391,0.025159663,-0.04357608,-0.044979393,-0.09850642,0.016372902,-0.024206594,0.050184,0.04490049,-0.05355018,0.03671748,-0.03669044,5.3477246e-33,0.08823276,-0.068049,-0.032374877,0.016048301,-0.012929914,0.05540112,-0.107293256,0.054567695,-0.009653863,-0.02788692,-0.04437126,-0.031653944,0.063628875,0.009026748,-0.019166032,0.0065977494,0.1032436,-0.066691525,0.0076427353,-0.028028913,0.06580726,0.07752348,-0.042591196,-0.025673123,-0.019255785,0.08913257,-0.012491169,0.11011982,0.0074006882,-0.011568169,0.005561228,-0.12996855,-0.069270976,0.10008707,0.092011355,0.037075285,-0.03244491,-0.004487765,-0.0116725415,0.018609764,-0.019888237,0.013067745,-0.0424605,-0.10939954,0.020073332,-0.06760387,0.00972032,0.05776777,0.06419482,0.041313764,0.07148089,0.02247394,0.10104773,-0.08349283,-0.05735324,0.02548339,-0.039983716,0.013537742,0.0077807307,0.113726236,-0.0151989935,0.07546874,-0.0044035474,0.008709942,-0.013488116,0.041877743,-0.09131527,-0.043360356,-0.044359498,0.062382128,0.041324068,0.0505947,0.20266977,0.012288195,0.06420547,-0.0019605244,0.017206447,0.019635668,-0.02376968,0.043029238,-0.017427213,-0.010507502,-0.045628645,0.024015844,-0.07048064,0.037035458,-0.029954737,-0.076502986,0.01186662,0.06523676,0.03416511,-0.041968558,-0.040872954,-0.021066042,0.077974655,-7.429282e-33,0.017023837,0.016752997,0.06584317,-0.080910765,-0.017646192,0.14416292,0.07622757,-0.037507944,0.008812058,0.026662972,0.115940765,0.0111789815,-0.053109467,-0.0043003103,-0.019089472,-0.016742554,-0.094990276,0.011062624,-0.028897867,-0.016556738,0.027636059,0.09665265,-0.01474522,0.08694247,0.083296984,0.037506882,0.025750756,0.04687282,-0.03582579,0.072804004,-0.021138255,0.07581723,-0.11626445,-0.015421424,-0.02931278,0.021028329,-0.08247272,-0.02756569,-0.053121135,-0.03457015,-0.032788076,0.0066806306,0.015610759,0.040153872,0.10018735,0.041215133,-0.015477061,-0.0041250354,-0.032905653,-0.029283626,-0.067235366,0.10643784,-0.039741118,-0.0062028747,0.046304867,0.03487279,0.06604055,0.03166679,0.03829547,-0.009213036,0.016040687,-0.042249065,0.020729361,-0.007146387,0.017709337,-0.046707682,0.008674378,-0.014689454,0.13376902,0.025682235,0.074220225,-0.045625314,0.017458444,-0.035195943,-0.030879505,0.02692539,-0.07345209,-0.02103137,-0.027838213,-0.008290813,0.036279798,0.037012644,-0.0087994505,0.00943055,-0.00449791,0.016410897,-0.040443,0.019850057,-0.08062221,0.02922897,-0.02340322,0.07514112,-0.066671975,0.0052833604,-0.00076331774,-4.0778414e-08,0.040897176,0.0027029365,0.082552925,-0.03361883,-0.0026348513,-0.065420076,0.0017410439,-0.0045732236,-0.0056628995,-0.016817583,-0.064932905,0.10161491,0.011050356,-0.032165844,0.023252383,-0.03346378,-0.02556026,-0.016216956,-0.025853759,0.0021265245,-0.0591648,-0.031027878,-0.13236398,0.029407885,-0.06376026,-0.062218342,-0.008430569,-0.035630133,0.09367234,-0.039022494,0.049746133,0.0021813388,0.011649537,-0.09247526,-0.010636469,0.0031746894,-0.035591215,0.046537958,-0.05443034,-0.013704639,-0.017667884,-0.09329934,0.012933791,0.03545287,0.0009207175,0.058116302,0.049994804,-0.01444798,-0.016440142,-0.0039545437,0.023943335,-0.05813503,0.017405884,-0.038032953,-0.069066904,0.054387204,-0.044939905,-0.06583784,-0.008057004,-0.04346671,0.017038312,-0.026694564,0.07162932,-0.01448629 +1.1.1.144,"Oxidizes a number of primary alcohols with the alcohol group allylic to an endocyclic double bond and a 6-membered ring, either aromatic or hydroaromatic.",384,0.99999994,0.017139068,-0.048196383,-0.05920063,0.059554767,0.0035324357,0.06517043,-0.05796656,-0.006454322,0.042460714,-0.0940337,0.04814937,0.03061688,-0.13569432,0.056438025,-0.05414041,0.1177283,-0.092849225,0.08755796,-0.060330752,0.03917677,-0.02325979,-0.0324161,0.09521696,0.026085954,0.060678065,0.08508226,0.05944651,0.0733498,0.004019595,-0.093521014,0.059948575,0.1130178,0.021231314,-0.03635144,0.03478877,0.020541338,0.004586179,0.016709145,0.05014017,-0.014118675,0.004559048,0.013458331,0.040966135,-0.032478362,-0.03446175,-0.026545571,-0.046702266,0.06730143,-0.0139321685,-0.0068938574,0.09607997,0.011807075,-0.087901816,0.08264966,0.07963547,0.023499329,-0.06375622,-0.02513011,-0.040114056,0.04273014,0.05734565,0.04089862,-0.034062006,0.07577245,-0.09034011,-0.02444401,0.06882395,0.04461047,-0.04801705,-0.035946894,-0.04803171,-0.08148015,0.009119025,-0.035057947,-0.0053124847,-0.0045851814,-0.003366201,-0.04792236,0.014457214,-0.03751877,-0.048200063,-0.025231065,-0.004326193,0.08609392,0.07580803,-0.018826533,-0.05394169,-0.07047565,0.0044460385,0.045924213,-0.055357087,0.009222588,0.020601973,-0.1141354,0.058704656,0.059926774,0.04612381,-0.016844328,-0.05927445,0.07423766,0.03303666,0.037073784,-0.048213173,-0.11151261,0.020595515,0.037692476,0.031088242,0.050373822,0.02680968,-0.01537288,-0.02018789,0.004080977,0.04109424,-0.09184899,-0.029038051,0.07556529,0.061657276,0.035125367,-0.021425394,-0.07319384,-0.015103197,0.013028393,0.00028715917,0.047770377,-0.045146476,-0.045833744,-0.020242022,2.480495e-34,0.04429362,-0.008166646,0.014150569,0.040509418,-0.009943894,-0.058235902,-0.03772732,-0.041837424,-0.015642136,-0.06671733,-0.056639675,0.019291881,0.014053557,0.03632807,0.08757286,-0.04911084,0.019806657,0.08081296,0.068091504,-0.07931894,-0.011250437,0.09473456,-0.022417495,0.026270386,-0.015640352,-0.00018290074,0.05385147,-0.0073888395,-0.0008261735,0.020455712,-0.016136859,0.10067506,-0.073527776,0.02758791,-0.047600634,0.08075866,-0.045920037,-0.04180292,0.025948882,0.012539908,0.0065783225,0.043494094,-0.041435316,-0.04568766,0.017986124,-0.02027067,-0.012769633,0.15414172,0.049774237,0.041933805,-0.016015083,-0.05287096,0.017591523,0.034391377,-0.07623655,0.05596563,-0.035865758,-0.031633787,0.020368243,-0.025236364,-0.033726238,0.000987838,-0.06955057,-0.031595845,-0.015708782,0.0043096906,-0.028067144,-0.062223755,-0.035411958,-0.007963259,-0.08735498,0.07824551,-0.007855921,0.09173763,-0.05024265,0.033428293,7.435562e-05,-0.017861832,0.09692116,0.043541055,-0.059422925,-0.047594663,-0.017953705,-0.008049462,-0.044987824,-0.01734022,-0.020280277,-0.036089364,-0.0011660177,0.060921185,0.031302456,-0.07223385,0.0021764322,0.015286843,0.079090334,-2.8993138e-33,0.07836653,-0.08692133,0.016008295,-0.014704506,0.003464203,-0.040273525,-0.012282767,-0.039662387,-0.055964477,-0.030779973,0.0036714282,0.0029266092,0.036272764,-0.06992806,-0.00044908925,-0.024484083,0.024758637,0.10201156,0.06313407,-0.018183826,0.050945595,-0.005592411,0.030638203,-0.03323012,0.04310931,0.017479211,-0.09411594,-0.073012345,0.03054446,0.043037668,0.039308462,-0.027170563,0.024501013,0.0052689123,0.032696147,0.12861934,-0.09493168,-0.04274285,-0.05576293,-0.019208295,0.0016732152,0.0073884334,-0.04047247,0.040798858,0.12572344,-0.039158933,-0.075874805,-0.057121333,-0.0040708026,-0.058636885,0.04293518,0.036694948,-0.053740863,0.038635742,0.04700796,0.0115103545,0.026159028,-0.08456286,-0.016102167,-0.022395251,-0.0647588,0.022689456,0.024142243,-0.049932837,-0.030938776,-0.037342343,-0.0619451,0.062141225,-0.010923272,-0.044331487,0.07583263,0.012343263,0.011351314,0.016461087,0.020200508,-0.11980596,-0.036528077,-0.111791536,-0.020152543,0.019700982,-0.023142006,-0.016503602,0.016590381,0.0049617607,-0.057644714,-0.08486491,0.15153976,0.056479193,-0.0011398229,0.04514959,0.028160112,0.049630087,0.0072264154,0.059865575,-0.01229575,-3.2240774e-08,-0.07358919,-0.03177472,0.0957001,0.04176159,-0.011927596,-0.0009863932,0.052898042,0.07636688,-0.051781643,-0.08552012,0.035063084,0.079815224,0.035328332,-0.035531957,0.043477103,-0.013899107,-0.048548568,-0.009536288,-0.041234057,-0.07298598,-0.008705238,-0.015163844,0.037277482,-0.02441946,-0.045754597,-0.05610452,-0.00014800996,0.0033024298,0.024169657,-0.017239958,0.03613996,-0.0008966384,-0.06590827,-0.0042488133,-0.06687165,0.049718615,-0.036602616,-0.0435528,-0.06318971,0.05285679,-0.029017515,-0.06068056,-0.08819975,0.045231473,0.09461816,-0.035411034,-0.010815586,-0.007875804,-0.0749718,0.028498013,0.06671408,0.023912318,-0.030920547,-0.01823915,-0.0724922,0.0253247,-0.02357925,0.05292083,-0.0043695057,-0.07783778,-0.0245727,0.05614914,0.08279811,0.013438014 +1.1.1.145,"This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Delta5-3-hydroxy steroids to a Delta4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3beta-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced cosubstrate, which remains attached to the enzyme, activates the isomerization of the Delta5 form to a Delta4 form (cf. EC 5.3.3.1, steroid Delta-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (converted to progesterone) and cholest-5-en-3-one, an intermediate of cholesterol degradation.",384,0.99999994,-0.024848102,-0.042414896,-0.058834504,-0.06473929,0.030939642,-0.0014894311,-0.05868397,-0.01054936,0.004381285,0.010887486,0.03435375,0.021937216,-0.097015284,-0.056586184,0.044752527,0.012998151,-0.04510696,0.05037343,0.010502173,-0.08113526,0.09371387,-0.09626179,-0.044162396,-0.008524231,0.0046782023,0.022393052,0.038258296,0.0064941575,-0.057973962,-0.070841655,0.0036592179,-0.013063407,0.007338181,-0.034037434,-0.08540464,0.052241143,-0.09273515,-0.07729065,0.04297131,0.09813187,0.060604203,-0.01262226,-0.048236784,0.026540285,-0.038260587,-0.1020178,-0.043993082,0.0018904275,0.013469095,-0.0068742954,-0.021075001,-0.055022545,-0.007252372,-0.0056165624,-0.067429304,-0.007791033,-0.010734279,0.004021945,-0.010812946,-0.02576077,0.016297156,0.03489713,-0.04170084,-0.013948867,0.009268351,-0.016956078,0.023152787,-0.054510962,-0.017020099,0.0055440036,-0.02049165,0.0039067976,-0.046709724,0.07793955,-0.056621246,0.07368161,-0.027407749,-0.029950345,0.025190437,-0.03406916,0.02614495,-0.0015921606,0.0012022665,0.1087253,0.060974937,-0.010550896,-0.063510746,0.009609935,0.0025135018,0.032465365,-0.0053504165,0.0025185307,-0.049798574,0.037607722,-0.07116992,0.07762954,-0.023978498,0.06673424,0.02179028,-0.020129045,0.03273387,0.08311092,-0.05590994,-0.03090319,-0.014930395,0.020740302,0.02914082,0.061587784,-0.04092047,0.030984728,-0.05720193,-0.052807894,0.023732105,0.00044193942,-0.036956526,0.13415763,0.031939834,-0.015012729,-0.021314908,-0.05103181,0.047495935,0.053087406,0.04904726,-0.015438111,-0.039175816,0.047649786,-0.008976741,1.3499167e-33,0.08273266,0.015736744,0.04073099,0.06993242,-0.04530399,0.038405247,-0.033621464,0.018982563,-0.0069605787,-0.036470514,-0.020438531,0.030750355,0.047885276,-0.00828542,0.018093737,-0.054646663,0.040766183,-0.020142289,0.09731564,0.037753135,0.021736983,0.10626679,-0.06494046,0.027040785,-0.03500539,0.050879795,-0.02150123,0.0168245,-0.02023687,0.019245896,-0.08005987,-0.07331384,0.035008974,-0.053740863,0.06791341,-0.026746346,-0.010233711,0.015223279,-0.03745944,0.04236269,0.056050044,-0.078284346,-0.027180629,-0.025188478,0.024338858,-0.021273741,-0.038589135,0.04612944,0.10568203,0.026714532,0.025598582,-0.024939708,0.100084044,0.019758733,-0.022724323,0.070104405,-0.02636166,-0.0455478,0.0064549474,0.017593727,3.8716764e-05,0.07669937,-0.01523525,0.048599772,-0.04402509,0.042871118,-0.03323655,-0.11017146,-0.055782158,0.031248389,-0.05519883,-0.019979086,0.02164176,0.052002236,0.07168585,0.08232659,0.00560436,0.021582063,-0.0013532415,-0.12181851,-0.07186846,0.018907245,0.03442846,0.040563848,0.008406965,0.036222685,-0.022530215,-0.02185281,0.016148372,0.042990796,0.04431408,-0.0084763765,-0.034184214,0.011454197,0.013576529,-2.7783665e-33,0.035257917,-0.07337555,0.015907751,-0.14289796,-0.055163205,0.1120739,0.048575487,-0.05352248,0.053735953,-0.026570838,-0.02686671,-0.046405397,-0.010862664,-0.104878165,0.012698872,-0.008480277,-0.037458792,0.041599125,-0.076682545,-0.03739391,0.0667088,0.17376658,0.05845066,0.11916289,0.04341067,0.010196531,0.08480835,0.004300894,0.06391232,0.07787203,-0.014168427,-0.053726558,0.06433781,-0.0026746416,-0.06163671,0.06605264,-0.05232783,0.05377586,-0.025371935,-0.0067859953,-0.11206506,0.0007120917,0.019637048,0.020195697,0.042374346,0.042908974,-0.07300538,0.031197168,-0.012510982,0.01841894,-0.0057239593,-0.053777825,-0.10318835,0.006401866,0.019905081,0.044888124,0.0039386344,-0.04065751,0.06979964,-0.05132646,-0.022057096,-0.012836064,0.039825343,-0.023667917,0.025307113,0.040536113,0.048817486,0.016182207,0.011119105,0.026378741,0.0060396297,0.043275446,-0.051418755,0.059497736,0.04649297,-0.026796557,-0.11470253,-0.045203168,-0.048883636,-0.011329123,-0.08170607,-0.00121562,0.005836557,-0.07128109,-0.063859835,-0.07788285,-0.01406907,0.083060294,0.04075969,0.056022357,0.008350111,-0.018268324,-0.107919276,0.067064546,0.03195313,-4.3374843e-08,0.0449162,0.0463399,0.024622062,0.010878261,-0.084431574,0.005194825,0.019202143,-0.0136923585,0.17242517,-0.070725895,0.008022113,0.13256395,0.077130295,0.010945307,-0.015970662,0.0028514452,0.015307581,0.048436698,-0.022912167,-0.02915061,-0.0650734,-0.034948517,-0.055996932,0.00013134275,0.05641368,-0.064637244,-0.027520463,0.072088555,0.021386346,-0.053228788,0.04937524,0.026931163,0.055628672,0.016289962,-0.010517725,0.06195092,0.008798574,0.006021445,0.0076928968,0.09795754,-0.06997161,-0.10103505,-0.048583873,0.062519915,-0.00067982153,-0.01949211,0.014070015,0.038443763,0.038828872,-0.008922212,-0.071440764,-0.012107728,-0.04479203,-0.08053413,-0.07413213,-0.02880588,-0.05620818,-0.055724815,-0.042974815,-0.06286911,0.0013362744,0.003175944,0.16193208,0.037912566 +1.1.1.149,Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase).,384,1.0,-0.03994398,0.02610323,-0.06488667,-0.050442997,0.03905178,0.064890675,-0.025479404,-0.0062913215,0.014794298,0.012725176,0.03984766,0.0175076,-0.09514564,0.027491437,-0.04213589,0.0012860841,0.004726247,0.065491565,0.04190685,-0.03462171,0.0048646475,0.04735897,-0.00026303207,-0.04036981,0.07987017,-0.031010296,0.029645823,0.1110494,-0.0628374,-0.06680001,-0.021541258,0.07553917,0.030202761,-0.08356992,-0.022091752,0.108548395,-0.10951859,-0.030884506,0.041732516,0.058219977,0.044588502,-0.0456628,-0.089587115,0.015663443,-0.023912348,-0.07031082,-0.041662876,0.10485368,0.05397891,0.042001996,0.03280495,-0.018882569,-0.0941981,0.049811084,0.08513176,-0.014158625,-0.018288242,0.009423691,-0.017894268,-0.024511393,-0.016967406,-0.059608497,-0.016661359,0.06179827,0.07536281,-0.035751175,0.099258564,-0.061556213,-0.026423732,-0.010960699,-0.021596825,0.016694447,-0.007909268,0.029327594,-0.03158392,0.066072166,-0.08016275,-0.04330304,0.04081094,-0.008440741,0.013736841,0.02037606,-0.020464616,0.010965246,0.07915425,-0.03869167,-0.018466396,0.008812168,0.03140938,0.05778758,-0.03203461,-0.036212422,-0.00965798,0.05162445,-0.07581209,0.040129557,0.066110045,0.014069332,0.046228018,-0.054833815,-0.017801568,0.10601637,-0.0798401,-0.026969174,-0.106186196,-0.021383224,-0.02604265,0.11035215,-0.06306091,0.031579405,-0.0050822934,-0.017175132,0.07111822,-0.019109853,-0.0008866304,0.10645121,0.001905057,-0.020709453,-0.06918197,-0.030939877,-0.018630087,0.0001305866,0.059521034,0.033056647,-0.018275037,-0.00043335496,-0.06311352,-1.5156895e-33,0.10609458,0.020138908,0.018056622,0.036892395,0.0064716353,0.08235622,-0.084706545,0.006726834,-0.047033437,-0.046590768,-0.03998527,-0.06704326,0.059654564,-0.05633338,-0.0045760944,0.031936135,1.0565031e-05,0.016523851,-0.013345561,0.0109926015,-0.02545207,0.14498289,-0.066682115,-0.0650663,0.01586959,0.07002604,0.009696464,0.08016968,-0.0083652185,-0.0068849516,-0.009401989,-0.06698712,-0.037538942,0.017421871,0.024746556,-0.017811561,-0.0060529327,-0.02689308,0.012754739,0.038526554,0.023944583,0.06785936,0.04367305,-0.06938378,0.058697466,-0.08881755,-0.012071622,0.06735305,0.015829014,0.05245091,-0.022458099,0.04496421,0.09945378,-0.088114634,-0.08544596,0.043019887,-0.08010075,0.06488412,-0.029126553,0.101899765,0.03957269,0.058360692,-0.011354275,0.10612409,0.018613722,0.027548797,-0.08212396,-0.071101874,-0.0045888186,0.0562977,-0.0130921025,-0.009453896,0.10625015,-0.043470904,0.009245345,-0.006316499,0.03631904,0.05987807,-0.0068196463,-0.023316633,-0.059869546,0.05335694,-0.08433598,0.001115461,-0.027104348,0.05095261,0.00042840207,-0.038370952,0.01314026,0.034605134,0.08406131,-0.044770133,-0.06354068,-0.083270974,0.055583145,-8.686668e-34,0.05304273,-0.030970449,0.034908194,-0.09448323,-0.008587433,0.09039539,0.06897301,-0.040222168,-0.019008746,-0.081830494,0.06010917,-0.036085963,-0.06895356,-0.10684306,-0.007360231,0.01643453,-0.111031294,0.0763024,-0.112779886,0.0062975646,-0.004149176,0.08783563,0.06547533,0.008031084,0.0718179,-0.016230391,-0.003193774,0.039391786,0.035305224,0.01573003,-0.03679248,-0.04305153,-0.113564126,0.046875097,0.027732475,0.028797753,-0.048939347,-0.020588228,0.024013154,0.063895315,-0.020117879,0.0559457,-0.032268662,-0.0024389406,0.06423792,0.044076525,-0.057324022,-0.02134149,0.062482376,-0.08625456,-0.033558246,-0.033575505,-0.092100516,0.014941729,0.009013908,0.0031651976,-0.034238365,0.04126549,0.050955344,-0.049530495,0.0059297546,-0.052081924,0.016090805,-0.020688418,-0.0060918676,0.021965155,0.008811953,-0.04847818,0.0014623286,0.0070628063,0.049668938,-0.021431636,-0.035741244,0.044844676,0.013786202,-0.12263444,-0.048817605,-0.0045690285,-0.063649006,0.0012198102,0.016075155,0.0032205628,-0.070657484,-0.048820097,0.048312448,-0.025121884,-0.026695408,0.059907388,0.021315822,-0.004791588,-0.03669364,0.028575374,-0.077702485,0.015621428,-0.012807366,-3.0292156e-08,0.042378943,-0.039714683,0.029111333,-0.018917348,0.059854038,0.011045288,-0.017377844,-0.040965553,0.07104935,-0.027080605,0.042160936,0.10620651,0.06891636,-0.0012731514,0.03624811,-0.031381417,-0.036018834,0.03613196,-0.008082204,-0.018588629,-0.063711934,-0.0110533,-0.09929336,0.07039305,0.018025305,-0.031491905,0.020109873,-0.02141447,0.051134285,-0.07760533,0.05581343,-0.016255679,0.103905804,-0.018969705,-0.05675578,0.02234594,0.002982195,0.062027548,-0.025599096,0.061571516,-0.030592559,-0.107390374,-0.04262718,0.06262191,0.020105895,-0.020462988,-0.0032455435,0.025458418,-0.042367555,-0.015249227,0.021729123,0.0029404047,0.018747352,-0.10056578,-0.022901632,0.04977104,-0.019386953,-0.06248096,0.010746371,-0.05715018,0.04844571,-0.02257584,0.095016636,-0.04666309 +1.1.1.150,Acts on a number of 21-hydroxycorticosteroids.,384,0.99999994,-0.018432286,-0.0036475207,0.024132973,0.040969685,-0.054783396,0.03062265,-0.04063059,0.030110558,-0.0140467025,-0.021273548,0.022150125,-0.033935633,0.0069876537,0.037533298,-0.030817948,0.027293945,-0.11264386,-0.015284986,0.05995643,0.01625729,0.030918078,0.0011649786,0.007171416,0.047279894,-0.026030911,0.024264086,-0.020265168,0.040401086,-0.034489162,-0.036476046,0.06481402,0.031691607,0.032044698,0.028538868,0.024746705,0.042876273,-0.0370713,-0.043201946,0.115555525,0.10130205,0.07885582,-0.13126971,0.04392138,0.031169359,-0.032842916,-0.038535353,-0.048748225,0.062006373,-0.008005269,0.03927033,0.0014658317,-0.075485714,-0.00895508,0.097242795,0.006949108,0.0049278173,-0.054446902,-0.014751296,0.025198929,0.03341594,0.045089584,-0.025448453,-0.004430379,-0.010112456,-0.028132357,-0.035103254,-0.042852063,-0.041430496,0.009306403,-0.0085449945,0.0503995,-0.005270124,0.018411886,0.064614624,-0.0963678,0.026248727,-0.0613534,-0.10072627,0.024989689,-0.076945975,-0.0024001726,-0.0069239526,0.012593066,0.08166805,0.039265685,-0.08135528,0.0370761,0.0360497,-0.059172023,0.0807151,-0.0102768615,-0.029668866,-0.0226969,0.020752296,-0.05842431,0.0026773885,0.037850667,0.021949045,-0.04343832,0.007842376,0.0013907306,0.065964706,-0.052690938,-0.024095066,-0.021766659,0.030220145,-0.001484111,0.008296717,-0.014976504,-0.043749157,-0.032480232,0.052726142,0.008504904,0.0157611,0.030582327,0.122914515,0.010813193,0.019109154,-0.014273743,-0.06393062,-0.024572315,-0.012909143,0.023772877,0.0073106308,-0.085331455,0.030908464,0.00036671292,-2.027271e-33,0.053929202,-0.0070926608,-0.019956047,0.029481139,-0.07264658,0.03964553,-0.055577673,0.03659875,-0.007896166,-0.0055046715,-0.060311295,0.0065649524,0.0739153,0.04181478,-0.013350347,-0.068754874,-0.017136365,-0.00014942484,0.033813026,-0.09621016,-0.026439717,0.08392434,-0.09726343,-0.043803915,-0.060936756,0.013384291,-0.030811451,0.05323292,0.048215147,-0.018248692,0.035746723,-0.06388701,-0.03974316,0.028260358,0.040195387,-0.009288194,-0.044208467,-0.03802376,-0.0024354158,-0.01652878,-0.0044633984,0.04207571,-0.030297713,-0.049547225,0.08194261,0.06262941,0.02434005,0.036156934,0.029371455,0.06273828,0.068612576,0.0027299814,0.05192903,0.013134472,-0.028772099,0.030447094,-0.014290287,-0.020824563,-0.022413021,0.0046604774,0.08783203,0.018256951,0.013512771,-0.044503916,0.0130023705,0.10803501,-0.067729324,-0.06344499,0.0039382027,0.073368676,-0.0076429993,0.0079421075,0.020170975,-0.063097894,0.033028692,0.03818179,0.008148047,-0.018659547,-0.07591536,0.049116906,-0.03533355,-0.023142872,0.022278514,0.017505497,0.016517095,0.065146826,0.003169001,-0.07924543,-0.012281588,0.05164218,0.0824851,-0.13277176,-0.072804175,-0.030180186,0.030120412,-2.6933923e-34,0.010059575,-0.03860188,-1.4202421e-06,-0.09100206,-0.0015116826,-0.007710701,0.010150534,0.023199975,-0.030273678,-0.027215734,0.034116343,0.041337475,-0.032048855,-0.0955998,-0.017656593,-0.03689056,-0.023516012,0.04515987,-0.007707628,0.023886885,-0.036837418,0.11710817,0.027501043,0.19113457,0.07274454,0.043888196,0.080402054,-0.07194172,0.06419717,0.0668713,0.014285345,-0.008860964,0.020052554,0.023167042,0.0040747416,0.0885139,-0.07803357,0.015464092,0.012319538,-0.10148861,-0.07668427,-0.04881781,0.076766476,0.078586265,0.07024962,0.047149293,-0.03841545,0.065604076,-0.10768928,0.051042527,-0.095589235,-0.01098748,-0.04859342,-0.04095521,0.0029659132,-0.03607322,-0.10268051,-0.053491637,0.06223204,-0.124148645,-0.0043911114,-0.025944341,-0.04145761,-0.07596788,0.018447466,0.0546988,-0.07316299,0.021980956,0.05395297,0.015641835,0.092186086,0.026871363,-0.027235517,0.029439108,0.029825801,-0.07306381,0.01695035,-0.029742075,-0.051290963,-0.04681588,-0.017948864,0.036712825,0.027113963,-0.05416163,-0.030821316,-0.044556297,0.032567162,0.014896195,-0.07774568,0.1334058,-0.007558853,0.057725005,-0.080582395,-0.021648418,-0.00016650844,-2.0965748e-08,0.03251525,-0.09334451,0.045754824,-0.011167506,-0.029655144,-0.01745839,-0.048250545,0.04698135,0.104683764,-0.027039876,0.011778034,0.06354334,0.07919407,0.048007168,-0.055925615,-0.09962071,-0.06294084,0.00030012656,-0.0661405,0.020005835,-0.10875493,-0.043010075,-0.012753888,0.065879054,0.009537755,-0.044634618,0.057603348,0.034536164,0.027648978,-0.010850819,0.1378341,-0.027018262,-0.016734324,0.034872208,0.037999935,0.12211279,-0.049247574,-0.04096722,0.023385655,-0.06203768,-0.064642034,-0.09268597,-0.0050276886,0.05893343,-0.0067586456,-0.05467059,-0.07531715,0.025931984,0.05234392,-0.02983935,-0.003250831,-0.06423938,-0.0046350313,-0.019365285,-0.07327163,0.032948572,-0.01001523,-0.04638466,0.002390743,-0.009797785,0.03677027,-0.003705764,0.14892876,0.021619188 +1.1.1.151,Acts on a number of 21-hydroxycorticosteroids.,384,0.99999994,-0.018432286,-0.0036475207,0.024132973,0.040969685,-0.054783396,0.03062265,-0.04063059,0.030110558,-0.0140467025,-0.021273548,0.022150125,-0.033935633,0.0069876537,0.037533298,-0.030817948,0.027293945,-0.11264386,-0.015284986,0.05995643,0.01625729,0.030918078,0.0011649786,0.007171416,0.047279894,-0.026030911,0.024264086,-0.020265168,0.040401086,-0.034489162,-0.036476046,0.06481402,0.031691607,0.032044698,0.028538868,0.024746705,0.042876273,-0.0370713,-0.043201946,0.115555525,0.10130205,0.07885582,-0.13126971,0.04392138,0.031169359,-0.032842916,-0.038535353,-0.048748225,0.062006373,-0.008005269,0.03927033,0.0014658317,-0.075485714,-0.00895508,0.097242795,0.006949108,0.0049278173,-0.054446902,-0.014751296,0.025198929,0.03341594,0.045089584,-0.025448453,-0.004430379,-0.010112456,-0.028132357,-0.035103254,-0.042852063,-0.041430496,0.009306403,-0.0085449945,0.0503995,-0.005270124,0.018411886,0.064614624,-0.0963678,0.026248727,-0.0613534,-0.10072627,0.024989689,-0.076945975,-0.0024001726,-0.0069239526,0.012593066,0.08166805,0.039265685,-0.08135528,0.0370761,0.0360497,-0.059172023,0.0807151,-0.0102768615,-0.029668866,-0.0226969,0.020752296,-0.05842431,0.0026773885,0.037850667,0.021949045,-0.04343832,0.007842376,0.0013907306,0.065964706,-0.052690938,-0.024095066,-0.021766659,0.030220145,-0.001484111,0.008296717,-0.014976504,-0.043749157,-0.032480232,0.052726142,0.008504904,0.0157611,0.030582327,0.122914515,0.010813193,0.019109154,-0.014273743,-0.06393062,-0.024572315,-0.012909143,0.023772877,0.0073106308,-0.085331455,0.030908464,0.00036671292,-2.027271e-33,0.053929202,-0.0070926608,-0.019956047,0.029481139,-0.07264658,0.03964553,-0.055577673,0.03659875,-0.007896166,-0.0055046715,-0.060311295,0.0065649524,0.0739153,0.04181478,-0.013350347,-0.068754874,-0.017136365,-0.00014942484,0.033813026,-0.09621016,-0.026439717,0.08392434,-0.09726343,-0.043803915,-0.060936756,0.013384291,-0.030811451,0.05323292,0.048215147,-0.018248692,0.035746723,-0.06388701,-0.03974316,0.028260358,0.040195387,-0.009288194,-0.044208467,-0.03802376,-0.0024354158,-0.01652878,-0.0044633984,0.04207571,-0.030297713,-0.049547225,0.08194261,0.06262941,0.02434005,0.036156934,0.029371455,0.06273828,0.068612576,0.0027299814,0.05192903,0.013134472,-0.028772099,0.030447094,-0.014290287,-0.020824563,-0.022413021,0.0046604774,0.08783203,0.018256951,0.013512771,-0.044503916,0.0130023705,0.10803501,-0.067729324,-0.06344499,0.0039382027,0.073368676,-0.0076429993,0.0079421075,0.020170975,-0.063097894,0.033028692,0.03818179,0.008148047,-0.018659547,-0.07591536,0.049116906,-0.03533355,-0.023142872,0.022278514,0.017505497,0.016517095,0.065146826,0.003169001,-0.07924543,-0.012281588,0.05164218,0.0824851,-0.13277176,-0.072804175,-0.030180186,0.030120412,-2.6933923e-34,0.010059575,-0.03860188,-1.4202421e-06,-0.09100206,-0.0015116826,-0.007710701,0.010150534,0.023199975,-0.030273678,-0.027215734,0.034116343,0.041337475,-0.032048855,-0.0955998,-0.017656593,-0.03689056,-0.023516012,0.04515987,-0.007707628,0.023886885,-0.036837418,0.11710817,0.027501043,0.19113457,0.07274454,0.043888196,0.080402054,-0.07194172,0.06419717,0.0668713,0.014285345,-0.008860964,0.020052554,0.023167042,0.0040747416,0.0885139,-0.07803357,0.015464092,0.012319538,-0.10148861,-0.07668427,-0.04881781,0.076766476,0.078586265,0.07024962,0.047149293,-0.03841545,0.065604076,-0.10768928,0.051042527,-0.095589235,-0.01098748,-0.04859342,-0.04095521,0.0029659132,-0.03607322,-0.10268051,-0.053491637,0.06223204,-0.124148645,-0.0043911114,-0.025944341,-0.04145761,-0.07596788,0.018447466,0.0546988,-0.07316299,0.021980956,0.05395297,0.015641835,0.092186086,0.026871363,-0.027235517,0.029439108,0.029825801,-0.07306381,0.01695035,-0.029742075,-0.051290963,-0.04681588,-0.017948864,0.036712825,0.027113963,-0.05416163,-0.030821316,-0.044556297,0.032567162,0.014896195,-0.07774568,0.1334058,-0.007558853,0.057725005,-0.080582395,-0.021648418,-0.00016650844,-2.0965748e-08,0.03251525,-0.09334451,0.045754824,-0.011167506,-0.029655144,-0.01745839,-0.048250545,0.04698135,0.104683764,-0.027039876,0.011778034,0.06354334,0.07919407,0.048007168,-0.055925615,-0.09962071,-0.06294084,0.00030012656,-0.0661405,0.020005835,-0.10875493,-0.043010075,-0.012753888,0.065879054,0.009537755,-0.044634618,0.057603348,0.034536164,0.027648978,-0.010850819,0.1378341,-0.027018262,-0.016734324,0.034872208,0.037999935,0.12211279,-0.049247574,-0.04096722,0.023385655,-0.06203768,-0.064642034,-0.09268597,-0.0050276886,0.05893343,-0.0067586456,-0.05467059,-0.07531715,0.025931984,0.05234392,-0.02983935,-0.003250831,-0.06423938,-0.0046350313,-0.019365285,-0.07327163,0.032948572,-0.01001523,-0.04638466,0.002390743,-0.009797785,0.03677027,-0.003705764,0.14892876,0.021619188 +1.1.1.153,"This enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. cf. EC 1.1.1.325, sepiapterin reductase (L-threo-7,8-dihydrobiopterin-forming).",384,1.0,-0.074260086,-0.069223955,-0.16009234,-0.0015049371,0.091275424,0.015882587,-0.033720482,0.060605228,0.030823985,-0.008028261,0.005464432,-0.078675434,-0.14956148,-0.033934537,-0.011613666,0.011240024,-0.022500688,-0.03790926,0.007335762,-0.08636128,0.013233146,-0.0007743852,-0.003233261,0.027357759,0.056266926,-0.08039771,0.068249546,-0.042706184,0.016207652,0.0035688388,-0.024782686,-0.09029658,0.054407302,-0.05498119,0.034936707,0.089578345,-0.10373112,-0.07394825,0.0410794,-0.036546674,0.034982882,-0.011461148,-0.07825918,-0.026225148,0.0031557144,0.026326092,-0.012607464,0.10647018,0.029785035,-0.03512581,-0.007567927,-0.027437964,-0.0408491,0.02542405,-0.021236433,0.014908815,-0.038093973,-0.049082745,0.05256102,0.06551556,0.030344468,0.010115227,0.045108557,-0.0704167,0.088814355,-0.045653082,0.038031295,-0.058081876,0.0038534822,-0.05844264,-0.050241794,-0.0015288098,-0.05073765,0.05026576,-0.03576778,0.02403392,-0.003546413,0.041351885,0.021089062,0.023521734,0.06847624,0.068198115,0.058104545,0.07520751,0.074688606,-0.036046684,-0.05395464,0.08089951,-0.0041991095,0.026427044,0.040692784,0.01111296,-0.00587958,-0.0069141877,-0.0120612215,0.069111,-0.011877259,-0.017789587,0.07549665,-0.032856323,-0.04034213,0.06433279,-0.014309935,-0.077501066,-0.08489233,0.021391395,-0.04910313,0.085211106,0.055974655,0.005332852,0.011743366,-0.012141502,0.021542488,0.0075323875,-0.013473767,0.09095928,-0.050595026,-0.04274973,-0.04677268,0.0685178,0.043755043,-0.015771663,-0.0012567671,0.108139515,-0.020220721,0.0014585546,-0.04987608,1.7338916e-33,0.032615233,0.062829874,-0.031995174,0.022284603,0.07828048,0.07223551,-0.047822237,0.025921408,-0.00089243165,0.018982548,-0.08405405,-0.13570195,0.01991108,0.0066163056,-0.053197995,-0.014928357,-0.03955611,0.0023416444,0.015174911,0.018917838,0.0029460497,0.049533363,0.008729026,-0.022282496,-0.016594231,0.11170878,-0.0947815,-0.018466935,0.083956875,-0.032497264,-0.015149501,-0.117809206,-0.11213496,0.046596672,0.05267664,-0.074665464,-0.025577324,-0.07062166,0.0111762965,0.07658992,0.05231807,0.044563394,-0.008688923,-0.030455986,0.088494144,-0.019841675,-0.013081086,0.00339895,0.07103447,0.021281999,0.020968715,0.014211851,0.047300845,-0.0870232,-0.07242051,-0.042266984,-0.04246123,0.029808844,0.10790425,0.021741645,0.028656235,0.047402937,-0.03444597,0.06603827,-0.05028835,-0.0054679625,-0.051754903,-0.03429319,0.020524427,0.039599262,-0.038925603,-0.046804607,0.0650715,-0.06737576,-0.0067330245,-0.06247083,-0.08197257,0.02257044,0.046041597,-0.048745677,-0.036053475,0.09922132,-0.015818259,0.017383704,0.003484144,0.028963314,-0.05490988,-0.034476377,-0.011616883,0.049352013,-0.016350236,-0.047967058,-0.06758072,0.011108834,0.061458986,-1.8275626e-33,0.11532771,-0.084354736,0.015979573,-0.13823383,-0.00862002,0.07713921,-0.012258841,-0.04349528,0.06318219,0.0032904877,0.09024045,-0.013549887,0.03546148,-0.040657446,0.034487437,0.0030077249,0.020386977,0.13155212,-0.0570848,-0.08624748,0.019156132,-0.006928559,0.030887332,0.013882059,0.05105588,0.016420688,0.0106276395,0.071533695,0.09293464,0.05031116,-0.030894207,-0.020301733,-0.04950986,0.017291844,-0.017294388,0.05801151,-0.056371327,-0.0014601793,0.050992534,0.011089701,0.06000506,0.02291103,-0.018390719,0.025810217,0.001726238,0.095448144,-0.035465986,0.058434967,0.022827655,-0.009449017,0.11642322,-0.02418931,-0.07079779,-0.014430358,-0.0042268676,0.012753682,0.05358063,-0.028732285,-0.038178995,-0.035667602,-0.058487307,-0.018230954,0.05332011,0.01104897,0.034046046,0.043740086,0.007838413,0.10307187,0.09018154,0.02165357,0.07303001,0.04387869,-0.025546778,0.021714913,-0.023207193,-0.011812314,0.0152437035,-0.04110512,0.0830555,-0.05250047,0.0032388861,-0.02038892,-0.0021997194,-0.021818765,0.010940102,-0.076348625,0.006036489,0.116338454,0.035023175,0.030432282,0.009601687,-0.03291269,-0.021173073,0.049852435,0.062231723,-3.5445403e-08,0.06866282,-0.08174054,0.02082259,-0.06564962,0.053185496,-0.006877484,0.03895586,0.033556525,-0.0537262,-0.06014431,0.01045205,-0.03839804,0.029792454,-0.016093971,0.059582274,-0.024627421,0.02887765,0.069360875,-0.005577591,-0.018573107,-0.028982515,-0.010976387,-0.038967565,0.00580976,-0.0058448073,-0.09661579,-0.050939597,-0.033779856,0.015610098,0.006231149,0.012632581,-0.00011601826,0.016086305,0.032857746,-0.021078642,0.035471853,-0.06731052,-0.027285969,-0.041762818,-0.07820171,-0.046804987,0.02446973,-0.03509866,-0.037546735,-0.06941258,-0.01950158,-0.019210706,-0.015482973,-0.015851248,0.040435825,0.016756296,-0.023224,0.05000019,-0.018953847,-0.069736145,-0.018937726,-0.026560765,-0.08187858,-0.0088998275,-0.09212075,0.033891857,0.054587215,0.15573554,-0.01606298 +1.1.1.154,"Involved in catabolism of purines. The enzyme from the bacterium Arthrobacter allantoicus can use both NAD+ and NADP+ with similar activity. cf. EC 1.1.1.350, ureidoglycolate dehydrogenase (NAD+).",384,1.0,-0.048578836,-0.013231669,-0.06276642,-0.039479338,-0.04445161,0.11180504,-0.033016153,0.011676076,-0.0056724455,0.047820635,0.010888516,-0.022515533,-0.0675949,0.051929034,-0.053117283,0.011504804,-0.034033302,0.01319031,0.08772704,-0.032785233,0.04468358,0.0088552395,-0.019142048,-0.06201901,0.071269415,0.050474416,-0.0061780117,0.005485603,-0.013464172,-0.09614793,-0.026104452,-0.041125715,0.0061191614,-0.04912258,-0.02086893,0.079746045,-0.082932256,-0.007900248,0.0212728,0.027355133,0.026391057,-0.0008465367,-0.067192316,0.015450943,-0.048445616,-0.049192373,0.018531261,0.06992792,0.026497258,0.017222848,-0.046809435,-0.016384266,0.04086527,-0.009674831,0.022089105,-0.06781229,0.0076323263,-0.037062943,-0.08924821,-0.110225104,-0.030832272,-0.031020382,0.014802652,0.029185012,0.044919908,-0.06233456,0.050566804,0.0072837034,-0.026306488,-0.04495906,-0.11296286,-0.03193139,0.0026378534,0.02504768,-0.04670478,0.044878516,-0.06424912,-0.054302663,0.061762497,-0.0066532167,0.030399954,0.026823835,-0.043982685,0.08229174,0.06565112,0.07157432,0.015389322,-0.028204251,-0.04446766,-0.012480901,0.05296188,-0.039334245,0.0072038705,-0.02370637,-0.07104297,-0.00062008714,0.017028643,0.027084054,0.026491145,-0.08290657,-0.0121200355,0.11529057,-0.038682044,-0.052202273,-0.013352358,-0.010208533,-0.032770213,0.07884969,0.027860422,0.014527192,-0.074863896,-0.021567136,-0.031577658,0.0033952207,0.008447272,0.10081948,0.035579164,-0.093729734,-0.06743494,-0.0722316,-0.03495726,-0.009058776,-0.03091808,0.07174631,-0.027192868,0.022915332,-0.08445319,1.8642892e-33,0.1032993,0.0062961094,-0.013334267,0.009002442,0.047718138,0.031679157,-0.07343738,0.041845962,0.019580571,-0.03825466,-0.078635946,-0.06107798,0.050988305,0.0033982552,0.025755182,0.038046747,-0.02824216,-0.0590585,0.068435065,-0.0011989651,0.018479437,0.08645291,-0.0024067133,0.023210732,0.022608267,0.0921621,-0.017831655,0.05087844,-0.022429597,-0.029432857,0.09034927,-0.08038041,-0.14254476,0.010954375,0.060854655,-0.032788143,-0.022897564,-0.018566696,0.0021196567,0.071825,-0.04371395,0.058004852,0.02626452,-0.045143124,0.06494679,-0.10464665,-0.04446569,0.083637364,0.047400985,0.105707906,0.06296956,0.0014409418,0.15243927,-0.11623551,-0.036392733,0.090189286,-0.044681452,-0.023029245,-0.027932107,0.12735005,0.039546642,0.021904038,0.05278222,0.050129924,-0.036026325,0.02141084,-0.09008575,-0.061064582,0.075478375,0.09026138,-0.0377976,-0.014471574,0.060325857,-0.029785402,0.037838712,-0.024353515,-0.05320899,0.0055124117,0.00749515,-0.0020431643,-0.0021537275,-0.044894796,-0.005157526,-0.013951048,0.014358356,0.049642824,0.036907345,-0.02971281,0.019086255,0.057323355,0.036279567,-0.0013437561,-0.042767555,-0.066780865,0.070223235,-4.025844e-33,0.11233583,-0.03595705,0.017614497,-0.12369146,-0.077106126,0.12195529,0.034416113,-0.06563717,0.018283037,0.039022673,0.05026651,0.0888872,0.035017263,-0.056017816,0.04075629,0.011750381,-0.058795094,0.06728049,-0.032991868,-0.021180289,-0.036875818,0.08162855,0.0414803,-0.054799408,0.07213141,-0.031987,-0.025252497,0.05524891,0.05704725,-0.06589548,0.021893695,-0.008017723,-0.045508157,-0.06042374,-0.030539349,0.0077866046,-0.05009295,0.022643596,-0.030131381,-0.0041156714,0.04507778,0.0067404606,-0.06583067,0.0521006,0.030757297,0.02632004,-0.14952128,-0.041197896,0.002170529,-0.08381687,0.05535766,0.011535211,-0.005047559,-0.00021035616,0.07495767,0.02690688,-0.018596826,0.021517783,0.025712837,0.00822348,-0.005049113,-0.010135949,0.028433863,-0.024761617,0.014450325,-0.013408381,-0.010110842,-0.007942894,-0.0024690721,-0.033804525,0.07093473,0.035430416,0.0072791413,0.034737542,-0.019096365,-0.03479616,-0.057472087,-0.018620335,0.0018121247,-0.040970996,-0.036221955,0.0044995644,-0.053980194,-0.06574614,-0.018951165,0.00034819022,0.008777763,0.0656423,-0.03687666,0.02857648,0.009594202,0.060680732,-0.011946502,0.025504356,-0.0056915707,-3.441557e-08,0.072448246,-0.007833579,0.03968877,-0.04734413,-0.011530794,0.019674001,-0.018108873,-0.021001818,0.03483602,0.006915997,0.025809063,0.10194758,0.089017846,0.046631426,0.064621106,-0.00036366697,0.020236095,-0.05149973,-0.03221678,0.007023054,-0.114096925,0.029767092,-0.12388345,0.089936845,0.07447383,-0.028567176,0.031806927,-0.03533591,0.010765964,-0.0062616244,0.022535339,0.03402622,0.043669555,-0.07668998,-0.017041638,0.043829296,0.019633843,-0.0630882,-0.02943505,0.027443267,-0.025011579,-0.10011143,-0.04436261,-0.00033872452,0.014126328,0.033412926,0.027213711,-0.0693987,-0.046447765,0.019503139,0.009178061,0.012554743,0.02568732,-0.071611375,-0.06807626,0.038186252,-0.013600583,-0.15548651,-0.0040262034,-0.008928667,0.08552268,0.004087243,0.11073598,-0.005981061 +1.1.1.158,"A flavoprotein (FAD). Sodium dithionite, sodium borohydride and, to a lesser extent, NADH, can replace NADPH.",384,0.99999994,-0.088561125,-0.056204982,-0.042266216,-0.03539888,0.08772044,0.034401428,0.015041844,0.069985695,0.033865783,-0.009289732,-0.0156727,0.07683774,-0.07063167,0.0067048906,-0.03240848,0.018665135,-0.0059021157,0.031844564,-0.027701229,0.01585487,-0.026437236,0.07058387,0.055688698,-0.019561183,0.061050177,0.016142534,-0.0047728424,-0.026245365,-0.01033959,-0.019182881,0.033575013,0.09060915,-0.024309348,-0.01808229,-0.0464694,0.042610146,0.012177227,0.03860229,-0.023927364,0.021399973,0.0402764,0.0015914411,-0.025797725,-0.016642287,0.037109047,-0.016858773,-0.0696194,0.088773526,0.03342454,0.08098252,-0.012039917,-0.025978643,-0.05797113,0.045303386,0.044570472,0.032820836,0.025007814,-0.0045177923,-0.012318302,-0.028179497,0.01226489,-0.045245595,0.05064321,0.018155826,0.058072947,-0.04261256,-0.0014884195,-0.028470162,0.04182799,-0.029080328,-0.028502505,0.014887781,-0.0060983445,0.03219332,0.021473838,0.074532665,-0.098291226,-0.08135212,0.07090161,0.0058318903,0.09443841,0.013928436,0.05433286,0.06644156,0.11572562,-0.014053678,0.004306736,-0.015100672,-0.059853915,0.0065653007,-0.03200591,0.0075335493,-0.007945994,0.0065638656,-0.15505502,0.058821447,0.029314594,-0.065272346,-0.06757643,0.013584119,-0.03303426,0.045426603,0.029988166,-0.03882771,-0.102900736,-0.051150344,-0.03148135,0.049266543,-0.06655354,-0.03724535,-0.005293045,-0.042997204,0.02336604,-0.07171738,-0.0168344,0.019170636,-0.019099075,-0.01537222,-0.07983936,-0.06339281,-0.045289133,0.056730296,0.045511976,0.0645768,0.050108,0.015492896,-0.10591735,7.909758e-34,0.1273653,0.029042153,-0.023109293,0.019750854,0.03590687,0.026918016,-0.07140276,0.010568349,0.063330114,-0.09357125,0.00024659125,-0.012511414,0.008953743,-0.08185991,0.08297066,0.016765984,-0.042524822,-0.06647887,0.080616005,-0.12092247,0.027975703,0.09476531,-0.037752926,0.07665067,0.0048886053,-0.030943591,-0.080134585,0.072698146,0.0060669994,0.031099254,0.032968294,-0.040270753,-0.061604682,-0.0021691618,-0.050829116,0.004901811,-0.112575725,-0.10470231,-0.083691224,0.036635246,-0.04445422,0.0019862219,0.002805074,0.011801149,0.019386707,-0.11353104,-0.026296483,0.06891942,-0.02494774,0.051983804,0.020321779,-0.039817285,0.09800576,0.0071798214,-0.089193195,0.015958115,-0.04400672,-0.03485961,0.0046434645,0.055725664,0.061136138,0.038794532,-0.022300515,0.121881016,-0.090445824,-0.032458328,-0.058141366,-0.08312101,0.026656933,0.06960051,0.060773205,-0.016846886,0.07173227,0.062784836,0.016847182,-0.042154957,0.033096053,-0.038355477,-0.0146535775,0.002328539,0.013729633,-0.05893725,-0.05003034,0.0020716577,0.008128277,0.04549241,0.030924933,-0.04975647,0.023914535,-0.016279249,0.032821514,-0.05277948,-0.005189308,-0.07894759,0.031494837,-1.7424477e-34,0.042012107,-0.036605816,0.06415253,0.039086666,0.01771223,0.04206297,0.095138006,-0.057540502,0.050685454,-0.10087685,-0.00045860148,-0.048927512,0.012224917,-0.003441878,0.028983036,0.040584795,-0.07573995,-0.019396605,0.022766653,0.037839055,-0.017939977,0.05664227,0.0670487,0.06436397,0.08589493,-0.04545241,0.017600594,-0.024021152,0.009965849,0.056954846,-0.008016475,0.051171035,-0.07808176,0.0020603081,-0.04268931,0.034702506,0.011038695,-0.050346013,-0.08798844,0.04504077,-0.059621505,-0.015335192,0.00045031897,0.021943623,0.08068311,0.033549484,-0.055309363,0.026875203,0.082301885,-0.064243466,0.055013202,0.04814987,0.017457547,0.05248233,0.07013487,0.011562869,0.014052778,0.063455574,0.006809527,0.021247087,0.042783987,-0.06648234,0.0019749587,-0.0043100603,0.12724525,0.019575719,0.036470417,0.0693052,0.012102597,-0.028570186,0.122186266,-0.0016681232,0.039152835,0.061832316,0.049446117,-0.0844831,-0.07280021,0.11440692,-0.0316923,0.014524912,-0.0009443343,0.01502552,-0.036918398,0.02849173,-0.055740237,-0.024416385,0.008699201,0.045995567,-0.021811571,0.0077060694,-0.054366678,0.06409997,-0.008715473,-0.014812689,0.042231068,-2.7852977e-08,0.041907694,-0.050933175,0.0013134424,-0.028966285,0.08971641,-0.016178507,-0.020961763,-0.04359907,-0.018365925,-0.025676088,-0.05476675,0.18247996,0.037198227,0.004752052,0.02502672,-0.029680833,0.01928648,0.017393809,-0.05030983,-0.03555339,-0.05348075,0.085122004,-0.075613454,0.046638202,-0.05132593,-0.0064088088,0.0113904895,-0.077985965,0.051919036,-0.046733174,0.021666758,-0.020372488,0.06907816,-0.072177745,-0.059733633,0.038417652,0.008269354,0.0016725528,-0.04671122,0.091466814,-0.07467919,-0.03874876,-0.010877529,0.011040061,-0.02739805,-0.06935292,0.04572226,-0.022174247,-0.07327157,-0.039813023,0.033822637,0.00067258027,-0.0032117881,-0.054216143,-0.064084195,-0.0282637,0.003991503,-0.055959605,-0.04226095,-0.08778726,0.027084244,0.026056552,0.080818504,0.0027950078 +1.1.1.159,Catalyses the oxidation of the 7alpha-hydroxy group of bile acids and alcohols both in their free and conjugated forms. The Bacteroides fragilis and Clostridium enzymes can also utilize NADP+.,384,1.0,-0.029783653,-0.08250913,-0.01092872,0.026497856,0.042683538,0.08189085,-0.07987392,0.018632011,0.032318007,0.03680143,-0.015029987,0.01097874,-0.04604365,0.03225227,-0.029798852,0.046423543,-0.11241289,0.03631085,0.028468756,-0.023898466,0.03128432,-0.025599329,0.05840746,0.020044325,0.0851576,0.072758816,0.06318639,0.01506683,0.014823473,-0.09732281,-0.02362087,0.030420113,0.039535437,-0.095869675,-0.016765125,0.0006656313,0.014839252,-0.012940113,0.05994379,0.0057042385,-0.025089867,0.020034099,-0.038630128,-0.038670044,-0.08089758,-0.04469633,0.07661478,0.08482262,0.05769269,-0.020007405,-0.024696168,0.01746291,-0.043655913,0.026165046,0.036141995,-0.026484435,-0.022829738,-0.119630076,0.021985132,-0.029044166,-0.014764442,-0.043157626,0.054631576,0.028007671,-0.06306329,-0.09992374,0.049438108,-0.012875878,-0.007883648,-0.06984563,-0.101919,-0.07468764,0.0061761825,-0.0012028068,-0.034118507,0.02876746,-0.024813533,-0.10695689,0.002890613,-0.015999362,-0.03019758,-0.021163514,-0.013731135,0.15386921,0.12331457,-0.045714792,-0.025532668,0.0044998606,-0.012605783,0.017817046,-0.0075706006,0.0020254322,0.027010355,-0.090955295,-0.029105991,0.033372115,0.056692194,0.03020452,0.02883198,-0.0014714376,0.0029807806,0.096691296,-0.017519074,-0.086877234,-0.0115134865,0.003271698,0.0108866505,0.12337268,0.0068692896,-0.09219495,0.0575184,-0.035716556,0.06389563,-0.052741583,-0.058121648,0.091772534,0.027647993,-0.07633366,-0.085345976,-0.015728109,-0.022673525,-0.0034495299,0.037715383,0.062192928,-0.04929262,0.010103724,-0.03437828,1.075385e-33,0.036340937,0.027015522,-0.052420575,-0.020386152,0.006256812,-0.024241444,-0.07737398,0.03634288,0.020026263,-0.03635846,-0.00806581,-0.035960373,0.05111557,-0.03321323,0.01034382,0.03831392,-0.008699382,-0.037332233,0.044728424,-0.023121368,-0.010687131,0.027480261,-0.011899466,0.01246535,0.05784996,0.05008184,-0.019367967,0.0383553,-0.01479743,-0.019495117,0.062189452,-0.042579275,-0.109881215,0.03578635,-0.010579355,0.05048417,-0.08396414,-0.047717173,-0.049104497,0.11755522,-0.01632673,0.026442891,-0.003650346,-0.034546673,0.0069641713,-0.011032718,-0.046163686,0.11197477,0.093364134,0.0839243,0.079946175,-0.0017988059,0.057557713,-0.09096647,-0.022478726,0.053117223,0.008960383,-0.010319963,0.033428263,0.07093718,0.047694523,0.022679912,-0.1010528,0.01698698,-0.016803226,-0.0040191854,-0.015550651,-0.0058559743,0.009616458,0.004316677,-0.06221996,0.08329613,0.067017555,0.044103418,-0.003027588,0.045899678,-0.0087655485,-0.022302179,0.029037138,0.025129866,-0.008657989,-0.05958822,-0.042662784,-0.014640898,7.682428e-05,0.029083276,-0.06038945,-0.043149844,-0.012850216,-0.0029484264,-0.014276464,-0.07509243,-0.03197753,0.0022354212,-0.020596799,-3.0866524e-33,0.071774855,-0.11356972,-0.0023239658,-0.114799425,-0.048751354,0.050433658,0.009821208,-0.04688267,-0.025243469,-0.0728291,0.02909901,0.016508276,0.041950647,-0.00753243,0.019804092,-0.010514866,0.048891187,0.077115856,-0.026089985,-0.05050143,-0.0008224117,0.1423267,0.029673453,0.06244503,0.051147677,0.006448576,-0.009985281,-0.02217562,0.08303704,0.12874472,0.010226743,-0.0006924127,-0.020804698,-0.018033097,-0.020475913,0.048139945,-0.08563203,0.0123993475,-0.014904166,0.0053900857,0.013639988,0.022884667,0.013938462,-0.004113493,0.021544527,0.016659765,-0.07974976,-0.01510924,0.045492165,-0.043361805,0.07609782,0.017510116,-0.047286753,-0.03709606,0.031211942,0.079721294,-0.037229396,-0.02493408,0.108041964,-0.087671585,-0.07686757,0.0012642659,0.057879403,-0.037658203,-0.008874454,0.044686183,-0.0612939,-0.0013543346,-0.006626479,-0.08440471,-0.005212891,-0.01880879,0.0056291944,0.047498297,0.009174474,-0.025094105,-0.02924739,-0.028200518,-0.008723115,-0.00844423,0.015061445,-0.009515621,-0.046294197,-0.06390204,-0.0036047033,-0.0025927566,-0.043220755,0.08083914,0.044311926,0.00054675736,0.0055500055,0.05005881,-0.038647838,0.008185731,-0.0076279435,-3.037782e-08,0.047414843,-0.051339112,0.09833936,0.05545077,0.021106198,0.06757159,-0.024628945,-0.053500384,0.012278484,-0.04436267,0.019080631,0.17490363,0.03600322,-0.018927569,0.008399911,0.05853867,-0.065304056,-0.054780222,-0.020704309,-0.07830747,-0.0936352,-0.010178593,-0.037356254,0.107893944,-0.010959945,-0.06118565,-0.025531521,-0.067572765,0.03318043,-0.062326703,0.020013794,0.05027724,-0.016086532,-0.03693684,-0.016068375,-0.044856273,0.0057495525,-0.041177444,0.021444667,0.060222045,-0.021973908,-0.058067605,-0.08027703,-0.009847185,-0.014230253,0.016558958,-0.039419506,0.059341606,-0.06167596,0.036167685,0.07222052,-0.029293165,0.026203949,0.016971843,-0.04909733,0.018577384,0.06219912,-0.06479141,-0.027232978,-0.05737761,0.0212992,0.028707478,0.23195885,-0.040072653 +1.1.1.160,"Also acts, more slowly, with NAD+.",384,0.99999994,-0.012518137,-0.113936335,-0.009536204,0.033657137,-0.011454622,0.05372065,-0.026789255,0.03844223,0.07780338,0.047254395,0.033262245,0.021524956,-0.0764308,0.10696209,0.04694484,0.0078094346,0.00427156,0.04259849,-0.019445667,0.010710188,0.039778717,-0.008931351,0.079736486,-0.043860853,0.01887076,0.0117685,-0.076459326,0.008833063,0.08250587,-0.1435309,-0.026437683,0.06131167,9.5095405e-05,-0.037810702,-0.07718375,0.07675385,-0.05988686,0.0026885073,-0.018898705,-0.024346238,0.04176659,-0.05175438,-0.0061410205,0.011640227,0.0036506345,-0.04615892,-0.011765582,-0.0037460576,0.05032902,0.017368276,-0.073454484,-0.072230056,-0.026202647,0.013561852,0.060008526,0.020004975,-0.052741915,0.025870712,0.013973624,-0.059087276,-0.033684254,-0.008752066,-0.039392967,0.066396214,0.069575064,0.01935246,0.074436545,-0.012838353,-0.03571495,0.022606192,-0.024439808,0.034052707,-0.011417002,-0.012436387,0.011951456,-0.020218039,-0.08566098,-0.07475523,0.034004956,0.024171034,-0.010972991,0.042527854,-0.10246486,-0.007106875,0.026814578,0.05564904,0.018800633,-0.080291115,-0.109562665,0.0035967075,0.014004682,0.02009671,-0.089913115,0.047547404,-0.053548727,0.01396868,0.021893432,0.014231276,-0.011627321,0.0004541608,0.019305784,0.09453455,-0.017072221,0.00019340513,-0.025390347,-0.008101766,0.048599098,0.0535697,-0.07693414,0.07208957,-0.038496245,-0.009803611,0.013747105,0.01725902,-0.024486467,0.09647459,-0.03735563,0.017124891,-0.08162038,-0.029037999,0.03160772,-0.004663226,-0.024000734,0.009974776,-0.01642868,0.035697658,-0.038229253,-3.0984767e-33,0.076786876,-0.034056183,-0.0043669306,0.034830373,0.017674504,0.010646952,-0.05730162,0.012636241,0.0076061576,-0.053403113,-0.07143582,-0.10501581,0.029360982,0.034380987,-0.009570121,-0.036249813,-0.032179564,-0.026288036,-0.06637255,-0.038343057,0.033959966,0.097235695,-0.03154294,0.012928385,0.03662415,-0.013672109,-0.009833225,0.036433887,-0.051329467,-0.0056487788,0.06089143,-0.054202233,-0.1236493,0.032733504,0.056505613,0.0802571,-0.025491362,-0.01952947,0.050040428,0.00747996,-0.09837654,0.056135125,-0.09806783,-0.04040117,0.018190105,-0.07987233,-0.00018542267,0.059589155,-0.023196876,0.059013225,0.0954552,-0.015306321,0.10789684,-0.024986919,-0.010239743,0.06913605,0.05842854,0.0032352135,-0.081536755,0.14502083,0.053968884,0.026456395,0.0043293033,0.05830278,-0.091030575,0.006204405,-0.1457062,-0.058048405,0.036049902,0.033211336,0.010093505,0.024930786,0.07141988,-0.032523233,0.03578101,-0.07923689,0.0153597705,-0.072173476,-0.0046287645,-0.026634468,-0.011448756,-0.05877161,-0.018982457,-0.019976683,-0.045319553,0.011316396,0.03262988,-0.080604024,-0.007519071,0.06529393,0.01915621,-0.04690627,-0.0275675,-0.036895297,0.017545555,1.4620322e-33,0.06550136,-0.029402554,0.054342344,0.023325814,-0.0024849693,0.089555465,0.03460662,-0.013426213,0.017756313,-0.05975707,0.057373226,0.049362455,-0.053307313,-0.02238249,0.06046693,0.013771714,0.03242336,0.05026668,0.028732745,0.0032121749,0.011509237,0.16549206,0.04540918,-0.0072317705,0.016142257,-0.020832563,-0.052225966,0.055513375,-0.008562867,0.0061751627,0.0015855489,-0.005870749,-0.1297401,-0.044589315,-0.0049210917,0.06162182,-0.032282658,-0.0077719293,-0.055301562,-0.00235947,0.018324904,-0.033272464,0.057108928,0.065676995,0.064460225,0.02664441,0.015568749,-0.034880746,-0.039596267,0.031506464,0.026956277,0.019730125,-0.088765346,0.045630455,0.07691849,0.0012846846,-0.011849071,-0.06778822,-0.029415155,-0.021733247,-0.011762439,-0.003045811,-0.008361147,-0.060981255,0.11480286,0.018527713,-0.01674522,0.002568053,0.12640686,-0.03203302,0.06633951,0.019278267,-0.04652987,0.02442256,-0.0669185,-0.059186522,-0.06783827,-0.033469424,-0.02538559,-0.07781546,-0.10624004,0.012482016,0.0038844084,-0.09085082,-0.12330073,0.06590111,-0.016401967,-0.04694054,-0.012946484,0.052921645,0.0036774522,0.04107541,0.048721183,0.024047747,-0.027682256,-1.7655358e-08,0.01549933,-0.01566611,0.034603912,-0.024224646,0.036141165,0.06377392,0.044831883,0.046874925,0.0186471,0.03372374,0.05861084,0.07628785,0.13879044,0.0027953486,0.11111174,-0.018199557,-0.051235404,0.023618776,-0.07556188,-0.01977816,-0.08514266,-0.011694842,-0.04588876,0.04751242,-0.027073093,-0.048773363,0.00021770036,0.0422079,0.031948563,-0.074449204,0.075167716,-0.012225612,0.03573516,-0.039445486,-0.047907475,0.07094414,0.07521788,0.032935407,-0.0072718174,0.094765514,-0.050256375,-0.062012598,-0.0238009,0.04718173,-0.028462738,-0.0318329,0.02623171,-0.08387257,0.03231497,-0.058739513,0.08294302,0.028450234,-0.019061297,-0.007538908,-0.04931435,0.068714425,-0.048103485,-0.0007495243,0.05402322,-0.005752368,0.080205634,-0.045206916,0.07137159,0.01643196 +1.1.1.162,"NAD+ is also utilized, but more slowly.",384,1.0,-0.06974394,-0.002708783,-0.08849107,-4.6099078e-05,-0.024059052,0.04258073,-0.07516485,0.045806024,0.068661794,0.028104743,0.026285809,0.052800555,-0.055039942,0.058293175,0.0074650818,-0.007989472,0.028064793,0.070278116,0.025284313,-0.016905056,0.038578846,-0.022754455,0.037317164,-0.039679196,0.10949181,-0.0004153006,-0.107832335,0.008491513,0.13423678,-0.05456488,-0.045836776,0.094687104,0.012056146,-0.046670787,-0.13715562,0.0271468,-0.061685324,0.02959036,-0.039536595,0.013925176,-0.02875927,-0.0155535275,-0.027202526,0.059051134,-0.013094741,-0.10487107,-0.007851992,0.018724574,0.02877903,-0.016526625,-0.03664119,-0.008385273,-0.06496706,0.011924223,0.08367143,-0.012910235,-0.043744415,0.0005038015,-0.038726497,-0.024679003,-0.04771001,-0.03999274,-0.054076266,0.036670305,0.07110361,-0.0033129659,0.091060385,0.0027446863,0.010260435,0.0016224668,-0.12562588,0.042765822,0.0174067,0.054052845,-0.0071193064,0.06110615,-0.06829454,-0.06860793,0.072598726,-0.005695005,0.019029984,0.06813603,-0.0953877,-0.006052911,0.10165602,0.091476366,-0.016728256,-0.011781997,-0.02644857,-0.045410875,0.03899731,0.043278903,-0.014825748,0.02419501,-0.084045924,-0.002090526,0.013016205,0.017870095,-0.018123956,-0.0051254584,0.03842003,0.08965579,-0.061473668,-0.018061168,-0.04024631,-0.05152592,0.056259353,0.09260849,-0.052839477,0.035736036,-0.023521578,0.020720992,0.019102264,-0.07544521,-0.07841512,0.10562983,-0.0068556513,-0.0015437258,0.018103592,0.013550131,-0.011014215,-0.006070368,-0.025595961,-0.00089266384,0.009305185,0.013220702,-0.022612663,-2.0382802e-33,0.05339682,0.022303851,-0.009945684,0.06141619,-0.03371824,0.04635185,-0.07446317,0.024050836,-0.024421645,-0.04458901,-0.0558655,-0.06664009,0.018490154,0.046456218,0.072366096,-0.040903796,0.004851729,-0.0114769675,-0.05642879,-0.028646953,0.06234564,0.033499505,0.030454816,0.032505304,0.098869264,0.03522521,0.038231876,0.037120897,-0.01915926,0.016719902,0.045800753,-0.08133881,-0.14673507,0.029759986,0.035291165,0.045251895,-0.051386014,-0.040903974,0.058491297,0.03472911,-0.109087445,0.05663228,-0.021601947,-0.05730526,-0.014575141,-0.11562456,-0.031621274,0.08160528,-0.041340604,0.022716267,0.03373096,0.039333224,0.03076245,0.007063068,0.0047728056,0.07966178,0.07676918,0.020990284,-0.065974444,0.18062891,-0.032283254,0.009458089,-0.0121259615,0.053264786,-0.07309697,0.036240615,-0.09004491,-0.06520659,0.0536044,0.019223344,0.028709674,0.014993713,0.041424073,0.007867449,0.051186018,-0.047709487,0.041235767,-0.04736872,0.029067134,-0.011763947,-0.0072831917,-0.0030365952,-0.035490513,0.0047507393,-0.030989494,-0.0061147436,0.03802578,-0.048732333,-0.013099066,0.028956564,-0.040479723,-0.035435256,0.00083510036,-0.06762212,0.0002132741,1.0832906e-33,0.025947014,-0.006201981,0.03883608,-0.0058094487,0.007594664,0.0367635,0.06970325,-0.12503457,-0.01602539,-0.07444251,0.035463363,0.040520646,-0.04248767,-0.018520094,0.039202437,0.007472325,-0.0411295,-0.041490503,0.004781694,0.012404064,0.013837968,0.13433176,0.050237034,-0.05387002,0.047527313,-0.05609877,-0.092887335,0.07251172,-0.02912781,0.020719653,-0.02851781,-0.038188484,-0.10070384,-0.08010494,-0.029920893,0.05793032,0.021257607,-0.005028257,-0.053273506,0.04104592,0.057932466,0.006250716,-0.018805921,0.04661505,0.018123688,0.03724851,-0.07137421,-0.058689415,0.053576887,0.00611889,0.076950856,0.00942346,-0.0958491,0.026754588,0.039552543,-0.030468779,-0.045223404,0.009479823,-0.0047526057,0.022913622,-0.015156001,-0.06428277,0.01532458,-0.078936495,0.07423548,0.031049507,0.0398264,-0.015752984,0.054142427,-0.060555033,0.07674667,0.06745193,0.022136549,0.027742965,-0.049126472,-0.049223077,-0.05610949,-0.0075003468,-0.071815155,-0.014078247,-0.058314037,-0.023972617,-0.045849912,-0.051721837,-0.01820715,0.02132655,0.002102983,-0.024998527,-0.035819247,0.046500344,3.4414973e-06,0.06727636,0.02478642,0.06771068,-0.036196146,-1.8540307e-08,0.028757755,-0.05517578,0.069011316,-0.059879433,0.022867484,0.023399405,0.028077768,0.019406684,0.0052193026,-0.0040803337,0.08595039,0.08123366,0.08820565,0.0036310842,0.06785389,0.010914518,0.0026941937,-0.010630915,-0.08128307,-0.049537167,-0.041033644,0.0691887,-0.08090901,0.060603056,-0.0013060911,-0.023726437,0.036202125,0.0026750409,0.09903479,-0.12226203,0.03178323,0.026600815,0.07844206,0.002597593,0.0056376937,0.1088736,0.018321546,0.068283506,-0.019719783,0.08833914,-0.04595989,-0.09256799,-0.027245207,0.06112051,0.028374558,-0.01636453,-0.026929628,-0.034724012,-0.023709033,-0.095542245,0.07233058,0.01584831,0.007992924,-0.07154115,-0.014923138,0.027372593,-0.00044671932,-0.048083413,0.04664461,-0.01903483,0.028063953,-0.05396185,0.06695919,-0.0073627406 +1.1.1.163,4-Methylcyclohexanol and cyclohexanol can also act as substrates.,384,1.0,0.015243892,-0.03358739,-0.028740387,-0.031717572,0.028149221,0.046170976,-0.0032389055,-0.012249586,-0.0062601627,-0.04096249,0.05166799,-0.106842496,-0.050087854,0.11559858,0.021142531,0.12263443,-0.039615467,0.045620926,0.03291919,0.06817455,0.048743866,-0.043445375,0.0013051854,-0.008160039,-0.04079488,0.03331699,-0.031989213,0.029549906,0.047607798,-0.046785887,-0.015998926,0.065500006,0.061097648,-0.015783342,0.048715968,0.02645958,-0.04796468,-0.045594264,0.029145742,-0.017069688,0.05166908,-0.053670876,-0.01768829,0.045572642,-0.014453813,-0.01134636,0.109332636,-0.028999342,0.010459195,-0.05949989,0.053058546,-0.012269121,-0.047165044,0.07059666,-0.035942923,0.015809665,-0.112987906,0.0415999,0.020591434,0.06739108,0.050097495,0.034550797,-0.0720365,0.044385705,0.014490462,0.020695226,-0.051983517,-0.017921869,-0.03173549,0.028467633,-0.025444154,-0.075211026,-0.00201385,0.005878646,0.043856792,0.069927305,0.047829166,-0.05339447,-0.0032636393,-0.0497908,0.0009487778,0.04704191,0.053695444,-0.0069816555,0.06304404,0.015908716,-0.04004855,-0.06829302,-0.0680372,0.013357918,0.016493317,-0.009115731,0.019599345,-0.055617616,0.01633815,0.018146234,0.06907275,-7.531169e-05,0.07411305,0.05890285,-0.017904082,0.04504303,-0.09763712,-0.03419721,-0.077191524,0.0042502233,0.014273379,0.038647756,-0.07078676,-0.0021035501,-0.03667303,0.00870665,-0.026967179,-0.010814525,-0.058184274,0.042966377,0.037631012,-0.026959503,-0.015431767,-0.014560799,-0.114617534,0.014668148,0.06053312,0.06322791,-0.024615202,-0.02088091,0.0061735455,2.692787e-33,0.050076142,-0.01848725,0.03549562,-0.08244373,0.009017424,-0.076141916,0.030507704,-0.032427926,-0.009308345,-0.05385671,-0.010427308,-0.008596301,0.05962914,0.05168522,-0.03080928,-0.011479767,-0.046401788,0.044955492,0.05816142,-0.027816117,-0.062498786,0.029631026,-0.031625107,-0.050109025,-0.026795328,0.019486789,-0.050691225,-0.02254734,0.052211072,-0.008312494,-0.07323405,0.03756245,-0.04123148,0.00420358,0.02419389,0.08886817,-0.065569215,-0.04639261,0.050138637,0.04313191,-0.062244035,-0.016477274,-0.003990921,-0.020065675,0.012314251,0.016467012,-0.09002827,0.0053508244,-0.043274924,-0.0008932203,0.031063933,-0.065946676,-0.0029361334,-0.06337069,0.0008744013,-0.008955666,-0.02345884,-0.04074784,-0.027711164,0.022077935,-0.06979898,0.03761717,-0.09839493,0.0772486,0.010778447,0.020174151,-0.05764499,-0.061483786,-0.09210399,-0.012047928,0.015049094,-0.045629885,0.11893056,-0.017060097,0.06844791,0.03682721,-0.05713689,-0.023490489,0.052468874,0.08845366,0.004090939,-0.080877654,-0.038931984,-0.09496413,-0.09678364,0.027295522,0.032474577,-0.1075935,0.0395437,0.057687365,-0.006409463,-0.049155872,-0.010873322,-0.002120012,-0.005207197,-5.9758022e-33,0.07296983,-0.015754411,0.0030408863,-0.10099699,-0.055130128,0.03763803,0.029061139,-0.09613397,-0.06547705,0.055134363,0.0786086,-0.0072428063,-0.044177223,0.015971892,-0.07767276,-0.018150123,-0.018476343,0.061768305,0.0076176766,0.018220197,0.023626234,0.08727447,-0.0168058,0.11359453,0.09012132,-0.047989953,0.0071919104,0.048620146,0.044620723,0.070394665,-0.11458771,-0.033295404,0.05392049,-0.017988412,0.075659886,0.07686245,-0.0057521383,-0.03342969,-0.09542954,-0.028391782,-0.034067746,0.017427884,-0.037270587,0.10396984,0.022133589,0.07515757,-0.059175894,-0.005391934,0.015722506,-0.047562767,0.023303675,0.043053154,-0.05022243,-0.03351729,-0.0012455601,0.118416704,0.022552846,-0.029222501,0.01265464,-0.043679923,-0.03382094,-0.09095031,-0.009760327,-0.1108172,0.09276759,0.021967413,-0.021205544,0.027854761,-0.026995903,-0.001152614,0.051026244,-0.003021967,0.022367658,0.013435003,-0.062144496,-0.070303775,-0.005660805,-0.12416744,-0.10058142,0.022616345,0.012923269,0.031564742,0.0009807949,-0.019596789,-0.0078065237,-0.021466406,0.030782936,0.052760683,-0.07806102,0.024933467,0.03397856,0.07391344,-0.014165403,0.112094276,0.041496754,-3.1073913e-08,0.064657316,-0.018648453,0.06848062,-0.084088504,-0.062289685,0.05428908,0.04786153,0.00096795306,0.04265463,-0.07732917,-0.01574577,0.09153493,0.014569121,0.061926574,0.08775332,-0.011470788,-0.064263634,-0.08340178,0.00803354,-0.05390743,-0.10933437,-0.019684598,-0.020623324,-0.006873601,-0.048969172,-0.0643217,0.070322745,0.14084522,-0.009974108,-0.008152854,0.05986105,0.01074922,-0.010849159,0.036196757,0.05285597,-0.0015194693,-0.03341685,-0.10372682,-0.078103505,0.04500004,-0.0794038,-0.006173655,-0.028475108,0.0562147,0.0422067,0.0022290281,-0.040035646,0.05429136,0.048417654,0.03276542,0.0072041536,-0.0125156585,0.0021743607,-0.04417414,-0.021825446,0.003890198,-0.037760552,0.021654278,-0.044716887,0.002547815,0.016093124,-0.004688165,0.1602309,-0.030910857 +1.1.1.164,The liver enzyme acts on long-chain alcohols from C8 to C16. The Euglena enzyme also oxidizes the corresponding aldehydes to fatty acids.,384,1.0,-0.005324067,-0.016387884,-0.036428783,0.03329327,-0.023644103,0.050032888,-0.13520172,-0.03489775,-0.009760225,-0.043573726,-0.004553552,-0.072247736,-0.12834254,0.0201164,0.006696132,0.046697892,-0.0866408,-0.03431014,-0.0327734,-0.06349566,0.022518042,-0.019952152,-0.00021518923,0.021508025,0.014681092,-0.03410925,0.08222763,0.018798556,-0.017219307,-0.10712457,0.015894098,-0.06575763,0.037587896,-0.021298045,-0.040975694,-0.03899616,-0.039483726,-0.016522178,0.0093344385,0.009779867,0.06388494,0.025287652,-0.050041154,0.017611273,-0.073543504,-0.042561434,-0.038728304,0.048263315,-0.02672334,0.056739468,-0.007414601,-0.05757966,-0.03132668,-0.01358518,0.0667869,0.003933982,-0.02594224,-0.027702434,0.041114926,0.00772212,0.010457471,0.001057377,0.041184977,0.05471586,0.03274512,-0.079670735,0.056190345,-0.055037793,-0.05123988,-0.093723506,-0.088155985,-0.1532787,-0.005905911,0.04265946,0.00019325207,-0.044429533,-0.08687926,-0.05547689,0.04241252,-0.0070701926,-0.041649096,-0.01694505,0.0060509043,0.069751464,0.0014382272,-0.027463475,-0.067361824,0.003675494,-0.044133052,0.07269036,0.046603095,-0.047850482,-0.042110976,-0.020027852,-0.01308472,0.04389973,0.090555534,0.054808058,-0.004838886,-0.01698571,0.035573494,0.087362476,-0.0533671,-0.04827424,-0.01567374,0.007885973,0.058130335,0.06989669,-0.0013699644,0.0038994744,-0.0128898155,-0.024094284,0.045505904,-0.036193606,-0.027752142,0.08630436,0.039172977,-0.025010675,-0.0030001393,-0.020675557,-0.049988035,0.020467421,0.096156545,0.08442377,-0.030593863,0.0424504,-0.01843455,-3.073496e-34,0.034299638,-0.054060347,-0.07432969,0.015084735,0.07109226,-0.08716019,-0.03056913,0.050693937,0.0023352478,-0.045963608,-0.04768531,0.049734462,0.011603098,0.009648824,0.003632992,0.00835034,0.018634837,-0.015639907,0.009271481,0.00096348836,0.01506183,-0.032088708,-0.003350861,0.013475009,0.05465148,0.038936015,-0.03147196,0.08584496,-0.0033320028,-0.0051006977,-0.04254615,-0.022470767,-0.07820316,0.010561611,0.03053934,0.05292466,-0.010885715,-0.0032916951,-0.057187516,0.037190177,0.08578479,-0.02681535,0.02770101,-0.041687366,0.018228859,-0.044995986,-0.13567343,0.13118874,0.02908677,0.059905384,0.10802183,-0.052124962,0.1064301,-0.018388608,-0.042486563,0.093074635,0.0087956255,-0.034539342,0.036834978,-0.004222094,0.028814128,0.028876964,-0.027357945,0.032016728,0.043309465,0.015629152,-0.1086588,-0.027585853,-0.11617567,0.00930114,-0.044712827,0.019255487,0.07683281,0.007336914,-0.030574376,0.02417785,-0.104356915,-0.025003204,-0.06312025,-0.0070470427,0.008491173,0.005032376,0.05006438,-0.054801058,0.02782279,-0.04333788,-0.0076061105,-0.04629177,0.013687041,0.035818536,0.03801838,-0.018481102,-0.06295245,-3.0151512e-05,0.090728,-3.0903592e-33,0.099138595,-0.10628251,0.045581657,-0.06767011,0.022207242,0.021221714,-0.004470477,-0.011589934,0.044081196,-0.029449929,0.053137857,0.0069314092,-0.014447793,-0.035333127,0.074809045,0.015290365,0.03289771,0.111732416,-0.019324183,-0.0997455,-0.025911229,0.048356738,-0.01166196,0.05442861,0.014480548,-0.035455134,0.012640708,-0.016373094,0.027924877,0.0081316605,0.00017351373,-0.0042879055,0.03275169,0.023717685,-0.023360651,0.045705203,-0.08825655,-0.00013654739,0.014054025,-0.0005494421,0.07777026,-0.026043627,-0.061688,0.029917711,0.049208757,0.025302382,-0.07691223,-0.040418446,-0.017684348,-0.029404428,0.10403325,0.010157365,-0.0060707782,0.06973205,0.041466035,0.121970445,0.043755498,-0.04004769,0.064278655,-0.08270318,-0.082218036,0.04072471,0.0319771,0.015112078,-0.030513022,-0.029256914,-0.0788078,0.03815149,0.00035235615,-0.034675356,0.08804414,-0.0008899531,-0.07329765,0.07362669,-0.06488876,-0.04275487,-0.011896572,-0.00650648,0.008376875,-0.04724695,0.0093052145,0.003042288,0.06546858,-0.01136236,-0.028190639,-0.08635398,0.00091245596,0.065788455,0.018845309,0.05930155,0.049716726,0.0040309536,-0.04099635,-0.0032630651,0.0026841853,-2.7272346e-08,-0.03795777,0.008204808,0.07929602,0.061702892,-0.059442807,0.039015166,0.035705023,0.0060315086,0.021155903,-0.06852859,-0.012212533,0.09513453,0.020260952,0.017871603,0.015178037,0.041412096,-0.09032452,0.011691771,0.012020214,0.008347589,-0.10115308,-0.005003457,0.03333036,0.06893378,-0.036395565,-0.045224443,-0.035251502,0.08489947,0.021383088,-0.013929334,-0.00804904,0.05749824,-0.03146648,-0.02260757,-0.065355554,-0.017348131,0.05456654,-0.07675427,-0.04817255,0.09432595,0.014957995,-0.11360467,-0.0873772,-0.07420497,0.025265833,-0.0026575248,-0.013612765,0.064624675,-0.03643593,0.036787257,0.031193784,0.05336354,-0.0090648495,-0.0049255597,-0.052248865,-0.05490016,-0.01733707,-0.051927026,-0.0029726124,-0.053233624,0.10159047,0.079823785,0.22699393,-0.014399747 +1.1.1.165,"Acts on a variety of 2-alkyn-1-ols, and also on 1,4-butanediol. NADP+ also acts as acceptor, but more slowly.",384,0.99999994,-0.0806284,-0.07069449,-0.056990128,0.049344696,0.0845752,0.023982318,-0.0018944695,-0.0005210166,0.10892371,-0.003506298,0.029574675,0.006719465,-0.0999566,0.080765516,-0.041602265,0.079630144,-0.0134820575,-0.007518886,0.019849712,0.039437514,-0.0073107537,-0.03342504,0.07663454,-0.046283323,0.033536542,-0.005863343,-0.036892645,0.039090753,0.1062314,-0.13796227,0.021950893,-0.00010564549,-0.043551337,-0.005541741,-0.058740404,0.06554879,-0.039532203,-0.016925093,-0.026803223,0.02458359,0.07042102,-0.0042583877,-0.02591768,0.017476425,-0.035249736,-0.09554622,-0.008271175,0.038958136,0.029782537,-0.08383934,0.010877451,0.024127841,-0.05727659,0.050135013,-0.0021333625,-0.015388989,-0.11634708,0.037756134,-0.032237235,-0.07861329,-0.0056624045,-0.02369645,-0.039603952,0.053555116,0.027402297,0.029591177,0.04256857,-0.04504189,-0.045766998,-0.009509105,-0.11084113,0.0075292774,0.017897766,0.013277045,0.053032458,-0.011739053,-0.053218562,-0.023406941,0.05525047,0.009232211,-0.0072744465,0.010952449,-0.056097858,-0.023524879,0.050692476,0.02537813,-0.07295301,0.031360365,-0.010362523,-0.019011611,0.0067873895,0.016261155,-0.0036662437,0.015711915,-0.019193232,-0.0054815006,0.086814836,0.018397257,0.00060903473,0.040052913,-0.018098278,0.08554041,-0.0646734,-0.040199332,-0.043388672,0.005274146,0.026811603,0.007463532,-0.09684483,-0.006608155,-0.056385238,-0.110931695,0.066758476,-0.034606047,-0.061043233,0.035537608,-0.019812766,-0.037757304,-0.029271998,-0.073839895,-0.023211906,0.004426279,0.026841603,0.049340222,-0.05795965,0.08114275,-0.03916588,1.9377664e-34,0.06916023,0.027399708,-0.03567788,-0.0027577667,0.0065014437,0.032281816,-0.05739371,-0.0078463135,-0.042588077,-0.018763825,-0.033396244,-0.064641096,0.06050055,0.047582302,0.022165427,-0.050546102,0.016612275,-0.016821863,-0.0035729476,-0.060080107,-0.0033985628,0.12951693,-0.05458193,0.031211516,0.031826347,-0.016396305,-0.025947563,0.06675725,-0.053382505,-0.031527203,0.07182462,-0.023702027,-0.16296823,0.027089765,0.032765787,0.036270894,-0.010744097,-0.05162813,0.06449387,-0.09382712,-0.114460565,0.04504471,-0.10025502,0.0040153153,0.030790262,-0.0643868,-0.013619923,0.06966589,0.004500771,0.01843939,0.030348003,-0.052048124,0.018853541,-0.018703807,-0.007879111,0.03732358,0.061638247,0.007118432,-0.026390482,0.08843898,0.028364459,-0.0013179799,-0.017778222,-0.045317754,-0.08796074,0.013062907,-0.07470663,-0.0784547,0.064242534,0.01943516,0.018955918,0.06037497,0.03592918,0.015414315,0.09419414,-0.039320428,0.010173483,-0.059139196,0.044644214,0.060904264,-0.06522079,-0.05370601,-0.019501382,0.013376216,-0.081678584,0.01991276,0.019446334,-0.0895227,0.04987908,0.054405693,0.029154927,-0.00017595667,0.024800468,-0.026648108,0.09060714,-1.875935e-33,0.04743747,-0.045664623,0.034586556,0.0009099678,-0.01893152,0.09469039,0.0002984726,-0.066647574,0.043577235,-0.05994489,0.13329843,0.061856627,0.039268967,-0.009513009,0.08063932,-0.012945387,-0.046006512,0.03176039,0.06665379,-0.017600292,0.023840878,0.12382954,-0.0065317997,0.011021866,0.022447502,0.0005084994,-0.024717717,0.0075236205,0.03668211,0.09322289,-0.026514942,0.018574128,-0.08513399,0.0148028,0.014400241,0.07165368,-0.03017218,0.03332817,-0.12689099,0.014413953,0.02152938,-0.04598579,-0.017826777,0.065736026,0.022978624,0.012299775,-0.015640538,-0.008696067,-0.01367369,-0.049861964,-0.0058532883,0.09423139,-0.046587393,0.0456452,0.09745176,0.090454794,0.01995572,-0.036447532,0.01626432,-0.030940285,-0.010711082,-0.05613821,0.056161627,-0.028475614,0.07756881,-0.047755394,-0.024990639,-0.020604694,0.11122333,-0.07080211,0.077762276,-0.019793786,0.031978495,0.044996288,0.003775263,-0.060342558,-0.02715998,-0.070102595,-0.055738058,-0.042723063,-0.09946312,0.048175216,0.0069641075,-0.05531362,-0.0818548,-0.021536851,0.043128837,-0.018122207,-0.03964558,0.05151274,0.08389475,0.09959267,0.021996858,0.0486416,-0.020582233,-3.30131e-08,-0.029325383,-0.012767482,0.07156427,-0.067717694,-0.021317845,0.023386404,0.05077864,-0.044142526,-0.026411397,0.0050070197,0.04410114,0.14164688,0.10904301,-0.039648782,0.097299226,0.008907253,-0.047599733,0.010816309,-0.03529544,-0.044320393,-0.055433616,0.0055109942,-0.04268335,-0.025048293,-0.021624947,-0.051773176,-0.012509353,0.04001922,0.046390742,-0.017388584,0.044447273,0.018521203,0.08126786,-0.032727063,0.03615012,0.09751613,-0.01957002,0.0032738384,-0.04297504,0.058146205,-0.03152164,-0.07490032,-0.025688335,0.028270496,-0.010108775,0.0593717,0.021998933,-0.06370287,-0.05065605,-0.018293379,0.06590936,-0.027591301,0.029070262,-0.03920223,-0.08801321,0.008944877,-0.07078306,8.061827e-05,0.038402174,-0.07618424,-0.00907796,-0.008653735,0.052956417,0.0015447288 +1.1.1.166,"Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial hydroxy or carbonyl group at C-4, including (-)-quinate and (-)-shikimate.",384,1.0,-0.010677104,-0.06455156,0.0057139,-0.06344301,0.017072432,0.03430838,0.004326834,-0.047828063,0.055257894,-0.057233505,0.050931133,-0.112370305,-0.037269004,-0.0105493935,-0.022380205,0.026567213,-0.09500862,-0.009467664,-0.004240573,-0.017318882,-0.027481804,-0.06939953,0.033175606,0.08599701,-0.021848975,-0.020392707,0.012429537,0.026979582,0.0005448055,-0.062409602,0.029598959,0.10510258,-0.029320661,0.038617566,-0.022410803,0.09187229,-0.030674824,-0.044749875,0.0530596,0.022545593,0.024267992,-0.053520236,0.08971408,0.016200371,0.024047393,0.026693864,0.013260904,0.06948701,-0.020634133,-0.04826212,0.03583495,-0.09130301,-0.07210023,0.096155725,-0.017205006,0.0003359707,-0.066839136,0.0047975434,0.04093253,0.053132214,0.019958712,0.06443561,-0.021459948,0.038038842,-0.08024714,-0.015760008,0.0016614838,0.048727002,-0.03418745,-0.030700633,-0.08321676,-0.08125964,0.02876874,-0.04011542,0.0037080008,0.049158204,-0.04060078,-0.05222288,0.0036709313,-0.06923374,-0.02788108,0.06682327,0.06937052,0.052809265,0.070650704,-0.045023467,0.005434306,-0.005372413,-0.037597332,0.011885481,0.052710865,-0.045671508,0.050495088,-0.017564021,-0.053716354,0.056891914,0.08355728,-0.016987002,0.065912545,0.046669852,0.027595509,-0.04889685,-0.0012665305,-0.10567421,-0.08842225,0.04911221,-0.02329819,0.07170634,0.006189192,-0.0019210167,-0.15061264,-0.048981935,-0.013706316,-0.10766477,-0.11695973,0.05436762,0.020482566,-0.022245584,0.021296928,-0.09084531,-0.02159928,0.010159804,0.062470283,0.016890902,-0.017709928,0.051699128,-0.057167947,4.3115458e-33,0.10667976,0.025607916,0.0838538,0.013351716,-0.06650542,-0.07539383,-0.07727803,0.015594201,-0.10883957,-0.025718937,-0.07413513,0.019627761,0.007821768,0.028051268,-0.027961051,-0.0018818608,-0.06150211,-0.052519966,-0.027787121,-0.038594473,-0.0763395,0.08861987,-0.07006194,-0.0022428478,-0.030783167,0.0044380375,0.025971722,-0.045192253,-0.020535726,0.027254947,0.022216689,-0.049873833,-0.09146718,0.06792528,-0.007541879,0.05405446,-0.023512546,-0.07022098,-0.025864692,0.10895047,0.062601045,-0.011810627,-0.015330402,-0.08121839,0.08538427,-0.017116953,0.04676016,0.07625281,0.0023165878,0.049083136,0.021133605,0.004356114,0.010856657,-0.012380955,-0.0724182,0.010838305,0.0015122553,0.028631661,0.020270566,0.015675476,0.036116153,0.0398723,-0.055777837,-0.103694856,0.012715626,0.017075535,-0.10131751,-0.02708297,-0.029403025,-1.9460762e-05,-0.017710602,-0.019103015,0.081764564,0.0806251,0.12361863,0.052611403,-0.031950023,-0.041531514,0.018739823,0.030039504,-0.035885595,-0.056512523,0.031303056,-0.04070083,-0.058762554,-0.009202235,0.0082463855,-0.004391392,-0.0035871211,0.013703231,-0.043807633,-0.03081649,0.047781374,0.045606986,-0.016093519,-6.0965854e-33,-0.0034561718,-0.003755021,-0.026234897,-0.010824832,0.025583567,0.015807131,0.015279887,-0.039810967,-0.022352355,-0.003854787,0.059995845,-0.035422925,0.07937609,-0.028762085,0.031150198,-0.06555595,-0.012487452,0.030687211,-0.022152971,0.049241997,0.01997319,-0.0061415415,-0.01754782,0.064284414,-0.02889146,0.05610052,0.042253584,0.013998758,0.07194795,0.12920113,-0.023410987,-0.027487282,0.0065699928,0.026218751,-0.01939453,0.04607473,-0.11233897,0.017569683,-0.07542289,0.04530477,-0.07465586,-0.008644263,0.04843451,0.09484071,0.057404313,0.04871056,-0.05145814,0.10053172,0.014815932,-0.0025953418,-0.04284338,0.06925783,0.05117007,-0.0013421786,0.056890655,0.086311735,0.022530397,-0.083047114,0.03574697,-0.07962587,-0.06740341,-0.035804212,0.04079832,-0.11261274,0.021098556,-0.02894013,-0.071564436,0.03452487,0.05718536,-0.03317375,0.069942236,0.019737901,-0.04994653,-0.023091668,0.0142205525,-0.0332009,0.040903818,-0.1254855,-0.034634005,0.023291467,0.032515787,0.014672708,0.062427722,-0.044954166,-0.029068463,-0.033850737,-0.01746892,0.025333602,0.03445205,0.048164226,0.030696899,0.097343035,-0.035202913,0.08551278,0.099344425,-4.3695906e-08,0.028877327,-0.034824867,0.058196157,0.021868864,-0.0663377,-0.016847609,0.0016216337,0.028907923,-0.009555455,-0.05483794,0.048052546,0.08349678,-0.017536119,-0.022840722,0.08005558,0.017893717,0.0016097599,0.05197139,-0.03107947,0.053682268,-0.06953993,-0.047900926,0.01590623,-0.034823056,-0.06877856,-0.06613083,0.05670581,0.03785703,-0.025892578,-0.01255871,-0.014189118,0.061729956,-0.040039733,-0.01274377,-0.057763666,0.020265408,-0.13324253,0.020920476,-0.027487135,0.0001762272,0.09349096,-0.034647044,-0.0676186,0.011603039,0.030550143,-0.013350781,-0.017009558,0.008471097,-0.007078678,-0.016857766,0.045579523,-0.016811319,-0.02021699,0.023457209,-0.069210716,0.06053927,-0.03716369,-0.041845653,0.05436083,-0.100280404,-0.06513535,0.032921776,0.10406855,-0.0073438683 +1.1.1.168,"The yeast enzyme differs from that from Escherichia coli [EC 1.1.1.214 2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.",384,0.9999999,-0.05428354,-0.06425954,-0.016840447,-0.09067018,0.0072090523,0.013623533,-0.07993034,0.06598641,0.012950722,-0.041236345,0.009434218,-0.07199902,-0.13764499,0.06261532,-0.0019707393,-0.04408936,-0.0068609943,-0.019304354,0.06850015,-0.011311873,0.06259385,0.005481182,0.018154271,-0.042464174,0.040473953,-0.020773496,0.06134447,0.0529913,-0.07543824,-0.13248357,-0.019409738,0.0060849576,0.03223349,-0.05920144,0.037145186,0.069480516,-0.029857775,-0.041833982,0.028456448,0.01947028,-0.020200172,-0.0047861454,-0.0699668,0.043749247,0.00085659156,0.009602389,0.009566431,0.09793974,0.015644738,-0.02275212,-0.014710259,-0.024994953,0.036723062,0.00329583,-0.02331094,-0.021635404,0.0020502221,0.026870776,-0.01122903,0.00024324728,-0.004212804,-0.052406803,0.022888178,0.032623347,0.017155036,-0.045663476,0.11617141,-0.07873227,-0.022609543,-0.010912947,-0.101093456,-0.036514975,-0.044941153,0.07209461,-0.0028657848,0.020216199,0.012738396,-0.03265475,0.05367399,0.0101661505,0.017713465,0.074344926,-0.016541462,0.010217836,0.087470815,-0.022065006,-0.007551639,0.04234472,-0.00055541244,0.010517925,-0.024433557,-0.014994127,-0.013248335,0.032788575,-0.037474938,0.058943667,-0.0073697553,0.092234336,0.0062664864,-0.068566,-0.0007600033,0.09107067,-0.012546354,0.038528644,0.022239449,0.018151445,0.024478683,0.090335354,-0.019323088,-0.014678423,0.019869244,-0.036732677,0.04033236,-0.045188643,0.0068819444,0.007541369,0.008806829,-0.04107937,-0.043077998,-0.024350414,-0.009184388,-0.05606279,-0.007161209,-0.003415019,-0.049505446,0.026619656,-0.12762283,1.3178047e-33,0.046505604,0.02428136,-0.0469248,-0.043305025,0.044235993,-0.0049530766,-0.04766331,0.050692193,-0.11982899,-0.002352239,-0.081548676,-0.047339283,0.021242157,0.057019334,-0.013918682,0.052225504,0.03551788,-0.021756878,-0.026363872,-0.038361955,0.009341712,0.03638216,-0.050120745,0.025085023,0.05634987,0.049326617,-0.065658696,0.067228444,-0.0071701654,-0.030014481,0.0028279775,-0.12873806,-0.04667007,0.041235775,0.085901454,-0.050441913,0.003509832,-0.055951577,0.002321807,0.021786964,-0.027506264,0.09135072,0.008762131,-0.045562174,0.048111368,0.021009823,-0.024175983,0.035859503,0.0169116,0.045396723,0.019224958,0.035351433,0.07975312,-0.07420252,0.029995637,0.055910747,-0.042750947,0.07219585,-0.0047691003,0.07250859,-0.011598665,0.09943254,0.013898851,0.10800093,-0.01853359,0.023928886,-0.06795852,-0.04402539,0.014996738,0.082636066,-0.067848116,0.030878067,0.03171406,-0.038174827,0.012692625,-0.0774914,-0.0067198733,-0.012056736,0.05068087,0.038644824,-0.024225447,-0.025162501,-0.052245412,-0.06130311,-0.0781049,0.05380975,0.039671827,-0.010095262,0.04120552,0.015421678,0.07278898,-0.075210415,0.0019692124,-0.029999,0.05333052,-3.5622618e-33,0.06770345,-0.018223785,0.075151466,-0.13134249,-0.08351673,0.17069457,0.08832012,-0.088543884,-0.031025613,-0.006231412,0.06410169,-0.0064822687,-0.032299068,-0.05463784,0.024168156,0.028396182,-0.08691443,-0.013681691,-0.023208663,0.004892706,0.026983857,0.12738371,-0.0356923,0.028684868,0.021286165,-0.042422608,-0.005940801,0.11284813,0.006470312,-0.042868387,-0.08999154,0.006697045,-0.039171044,-0.032026052,-0.0011478206,0.020317014,-0.1050225,-0.005639144,-0.023291742,0.07002375,0.011115229,0.036556173,-0.079840705,0.06595064,-0.010628508,0.09373982,-0.06381487,-0.0034307195,0.07366664,-0.09094036,0.021693176,0.029335655,-0.012519823,0.028105097,0.028321005,0.0073713576,0.022993004,0.06558521,-0.007797598,0.02396207,-0.0057609486,-0.11823781,0.06372635,0.0034971444,0.03644332,0.02737483,-0.029894793,-0.026794221,0.048414033,-0.014511698,0.0351401,-0.03157044,0.020975301,0.045091864,-0.08022331,-0.096343,-0.08076517,-0.015657369,-0.046022598,0.019084582,0.034901395,0.0016001866,-0.017046789,0.036251664,0.06270023,0.0063295737,0.007756807,0.029879902,-0.027213873,0.05740584,0.00056499895,0.036354303,-0.07719222,0.03562963,0.0036750415,-4.3594234e-08,0.088322945,-0.008878507,0.036651075,-0.12930539,0.040026523,0.034749184,0.011894686,-0.050507452,0.01925371,0.055503614,-0.03806378,0.13621426,0.026492031,0.07238992,0.092634164,-0.030597022,-0.033759497,-0.012637219,0.026360117,0.026359646,-0.025527338,0.008823984,-0.15282655,0.034151997,0.021675268,-0.045886938,-0.0121429805,0.03937219,0.042973198,-0.021537038,-0.0032296416,0.014559545,0.057176117,-0.03413142,-0.022920582,0.005494405,-0.1009771,0.006440021,-0.07902715,0.01167129,0.03500337,-0.08952802,-0.034774687,0.026861902,-0.057113316,0.03540209,0.07253185,-0.023305675,-0.018783579,0.010259881,0.045579854,-0.021102084,-0.013027237,-0.0224358,-0.080636755,0.0416213,-0.057722833,-0.079190955,-0.009244492,-0.035736714,0.079709664,-0.05797486,0.11672467,-0.06552222 +1.1.1.170,"The enzyme participates in the biosynthesis of several important sterols such as ergosterol and cholesterol. It is part of a three enzyme system that removes methyl groups from the C-4 position of steroid molecules. The first enzyme, EC 1.14.18.9, 4alpha-methylsterol monooxygenase, catalyses three successive oxidations of the methyl group, resulting in a carboxyl group; the second enzyme, EC 1.1.1.170, catalyses an oxidative decarboxylation that results in a reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group; and the last enzyme, EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, reduces the 3-oxo group back to a 3beta-hydroxyl. If a second methyl group remains at the C-4 position, this enzyme also catalyses its epimerization from 4beta to 4alpha orientation, so it could serve as a substrate for a second round of demethylation. cf. EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating).",384,1.0,-0.040253486,0.02060497,-0.07389079,-0.05570238,0.011562133,0.030786077,-0.13915268,-0.018244226,0.04581352,-0.07065206,0.0498792,-0.0453008,-0.07749427,-0.09519056,0.031145554,0.028585833,-0.10299694,0.060185876,-0.018733405,-0.04032835,0.07354167,-0.014939924,-0.0672552,0.000594846,-0.009152453,-0.009691127,0.027985256,0.02055885,-0.0553662,-0.105716206,0.033186667,-0.012361715,0.067954145,-0.0017867401,-0.031775024,0.08730714,-0.042154986,-0.097344235,0.0063334904,0.098840386,0.03464189,0.01583792,-0.031119112,-0.033386808,-0.016275518,-0.061681867,-0.010824033,0.021804944,-0.023979584,-0.08753769,0.060299404,-0.062411647,0.007663619,0.034840573,-0.009836275,-0.0027658339,-0.031651158,0.03512115,-0.06559683,0.026563102,0.05857534,0.0127867805,-0.053639155,-0.01485288,-0.02689715,-0.05266931,-0.0043795733,-0.06697481,0.011863535,0.0004619718,-0.07045506,-0.05153574,-0.035222363,0.014012394,-0.04265381,0.015391371,0.021182291,-0.030821761,0.06637006,-0.0811565,0.07088724,0.03952417,0.003969916,0.063492276,0.06650334,-0.0044528386,-0.0125631755,-0.01600025,-0.007010447,0.07849846,0.08757698,-0.0068416162,-0.027575212,0.077628136,0.0066912733,0.090640165,0.11190197,-0.007393399,0.0258624,0.0047324463,0.028330758,0.05363376,-0.05292191,-0.03834788,-0.0028026102,0.021816442,-6.41541e-05,0.07006356,-0.014787413,0.031139385,-0.030100716,-0.015860645,0.0376106,0.019875646,-0.065775715,0.12650326,0.052409757,-0.04961215,-0.03235663,-0.045226827,0.03758415,0.007019173,0.08576233,-0.007699419,0.038356803,0.06291164,-0.08496738,2.580591e-33,0.06513985,-0.0062760534,-0.046489645,0.0039669666,0.04542742,0.0037037015,-0.047420293,0.10263909,-0.050714407,-0.030194096,-0.067249425,-0.05086614,0.062239688,0.043831922,-0.054600917,-0.08911376,-0.005481728,0.057647776,0.02668449,-0.04139689,-0.027254786,0.018692456,-0.06743862,-0.015501401,-0.06288421,0.013799247,0.016815698,-0.027163805,0.041355763,0.012506239,-0.031281028,-0.09920881,-0.06850017,-8.1404316e-05,0.04837175,0.0042971745,-0.007105337,-0.043284796,-0.021087354,0.09554211,0.027414305,0.032592688,0.013669695,-0.07682487,0.031074297,-0.029752538,-0.06991857,0.0773568,0.08795718,0.09020418,0.047107838,0.03610022,0.07928558,0.009157673,-0.019563727,0.036370452,-0.06583076,0.02817536,0.033377547,0.007260632,-0.010735167,0.092862256,-0.055749834,0.02234081,0.015430116,0.032498326,-0.11389327,-0.04928731,-0.04475408,0.062715985,-0.033395536,-0.03345181,0.044308573,-0.017309142,0.039183833,0.06569811,-0.016356608,0.052984755,0.017666098,-0.041410208,-0.05074461,0.06723962,-0.009925647,-0.0903422,-0.057440113,0.03129233,-0.0081126345,-0.028519012,0.026327467,0.030418105,0.016230902,-0.02290944,-0.05085657,-0.00084537594,0.0080487365,-3.6423842e-33,0.05993764,-0.06231052,0.038169414,-0.12813015,0.039648328,0.04610652,0.008191979,-0.057844803,0.03600427,-0.04841331,0.03685829,0.068007894,0.021021117,-0.03212548,0.05844293,0.0013472479,-0.042734347,0.018081343,-0.07334316,0.009132449,0.0391837,0.114901304,-0.027625095,0.121470146,-0.018764796,-0.028822994,0.0023008506,0.012565796,0.09886048,0.048424352,0.045497812,-0.06970358,-0.021894498,0.059943434,-0.033261247,0.07807284,-0.07567558,0.019474534,-0.0037365432,0.07794956,-0.047365002,-0.029046625,-0.028864194,0.014561087,0.1037819,0.037445616,-0.06441445,0.05543808,0.029096114,-0.013683503,-0.028015267,-0.019947268,0.013559469,0.08784136,0.03476578,0.0072688395,0.02739902,-0.056336142,0.050884757,-0.03311255,-0.007234552,-0.01807732,0.0026692662,-0.01616548,-0.011726616,0.014877896,-0.014430804,-0.02782651,0.04016294,0.0061791246,0.04442254,0.06361947,-0.029693395,0.0080444245,-0.0012673863,-0.046355475,-0.050669197,-0.062921345,-0.10263541,-0.031159362,-0.025189599,0.02162403,0.06276175,-0.08733929,-0.08472102,-0.087219775,0.015457629,0.09248545,0.021904318,-0.002683242,-0.0052678925,-0.020691099,-0.06472855,0.11429738,0.048429217,-4.796806e-08,-0.004769398,-0.044909522,0.0531377,-0.013023625,-0.082519874,0.017116163,0.029138999,0.044493556,0.09252561,-0.082814366,0.015866082,0.12931105,-0.004373275,-0.004812356,0.057539113,-0.03085376,-0.030945987,0.0056374143,-0.014336161,-0.03699977,-0.03436564,-0.021846302,-0.046734165,0.0033647548,0.02547923,-0.051037177,-0.02472019,0.0669388,-0.014569298,0.0031283218,0.08167685,0.092007175,0.08093042,0.055655774,-0.032112226,0.0022964946,-0.0154517125,0.0120333275,-0.025126005,0.0785087,0.03949632,-0.10218461,-0.054803368,0.01579714,-0.0024642558,-0.035504397,-0.0042424654,0.03974156,0.028724425,0.0040326966,0.012240773,-0.014804967,-0.020095099,0.012779452,-0.059022844,-0.03605682,-0.09414547,-0.07510842,-0.021762462,-0.043759335,-0.00094915234,0.04105417,0.19354783,-0.0025560388 +1.1.1.174,"Also oxidizes, more slowly, the cis isomer and 2-hydroxycyclohexanone.",384,0.99999994,0.0031336301,-0.061805364,0.017370475,0.10900403,0.06483375,-0.06494845,-0.07908442,0.04553161,0.064958476,-0.094439,0.06924524,0.05395918,-0.0053052115,0.0490788,-0.012389432,0.04983306,0.010926373,0.08726195,-0.04634375,-0.005537902,0.045036417,-0.051802184,0.017874908,0.06295261,-0.030732706,0.029854737,-0.009094156,0.08371039,0.0048080706,-0.04808518,0.029308854,0.03544995,0.0074347714,-0.063844405,-0.018203767,-0.0061417567,0.034241896,0.015018376,0.05069687,-0.0071457913,0.006168606,-0.06974491,0.021953149,0.030032655,0.034939993,-0.017919537,-0.008009792,-0.049730282,0.0061771744,-0.0013217251,0.0013044564,-0.030949464,-0.07420172,0.025093533,-0.017001951,-0.009554038,-0.0894973,0.044999722,0.009223652,0.03733294,0.02201348,-0.0012401271,-0.034642786,0.044170775,0.01680089,-0.05649473,0.040013008,-0.06029308,0.024539234,-0.008085229,-0.031988423,-0.013581381,-0.024274237,0.008488339,-0.027201954,-0.024932358,-0.028233325,-0.10236283,0.020817775,0.01227718,0.020834217,0.047190305,0.028682048,0.06304478,0.062112108,-0.0059182444,0.018080812,-0.10337124,-0.1526859,0.008121581,0.031033415,0.07332626,0.020163512,-0.037772294,0.008514921,0.004764802,0.029142294,0.0940654,-0.052386742,0.0082156295,-0.04125636,0.02494367,-0.111645445,-0.1033219,-0.061560415,0.008109008,0.018276708,0.04969981,0.012737621,0.06934732,-0.016244614,0.011063114,-0.026791567,0.001935595,-0.03446209,0.10731971,0.026623148,0.040781762,0.0053455536,0.026540946,-0.049028702,-0.048788927,-0.016236043,-0.011605754,-0.07175466,0.01144844,0.06127481,8.741845e-34,-0.0031944425,0.036429927,0.022640144,0.029853053,-0.021626104,-0.01183053,-0.08709008,-0.047207974,0.016863905,-0.026093129,-0.082426324,0.0016308276,-0.0063227676,0.05065668,-0.025941629,-0.09905125,-0.046210434,0.06628278,0.036707323,-0.033074856,0.035071746,0.026749132,0.000937132,0.03613091,0.025110332,-0.0056833965,-0.03379378,-0.010585218,-0.015968412,-0.008063962,0.0076660635,0.014157253,-0.0981863,0.006823484,-0.0365935,0.08326287,-0.06998934,-0.036454543,0.035760976,0.073850974,-0.061722096,-0.0023347891,-0.04247059,-0.035281755,0.08065324,-0.038510945,-0.09216136,0.105013914,0.04085021,0.022758953,-0.013129499,0.0020677084,-0.04233731,0.0032764236,-0.016708208,-0.009940928,0.06426634,-0.064807005,-0.010599096,0.040165287,-0.05570915,0.07967271,-0.052262347,0.0422674,0.03715682,0.06436747,-0.059988692,0.027767753,-0.044287093,0.009864441,-0.07232241,-0.030990828,0.1505591,-0.026381645,0.023103138,0.0052057854,-0.118557304,0.003239814,0.06598363,0.0066952403,-0.03758837,-0.07798199,-0.0060538375,0.0116295945,-0.034373138,0.018457778,0.016750937,0.04552206,0.0519583,0.049399372,0.08490991,-0.11186299,-0.07678122,-0.04371438,0.027393749,-2.6504238e-33,0.09477616,-0.09288849,-0.020942435,-0.029701766,0.0043591466,0.016187444,-0.016216623,-0.030309977,-0.0008260985,-0.02494293,0.1032868,-0.039700486,-0.08412697,-0.0052176723,0.01105625,-0.031355105,0.008305851,0.05880624,0.0025709656,0.019084595,0.05798431,0.07404262,0.01264922,0.07658772,0.05083729,-0.01929076,0.0045614233,0.0059953863,0.090026975,0.091460906,-0.04648981,-0.046360727,-0.036286097,-0.038395517,0.043556917,0.07962685,-0.08712661,-0.012482932,-0.060813323,-0.023622204,-0.032314833,-0.019258445,0.025335222,0.044904772,0.06693828,0.0684365,-0.07214543,-0.09368032,-0.023479363,0.0052471613,0.06724933,0.016974801,-0.09252102,0.038478065,0.02276034,0.007290873,-0.12100448,-0.05041222,-0.0046594995,0.024430275,-0.0383415,0.00061010075,-0.0022030978,-0.07230496,-0.005904793,0.015005815,-0.06079646,0.014267403,0.07628408,-0.011827981,0.08149162,-0.045702696,0.04300038,-0.019863663,-0.0447268,-0.10056844,0.024676077,-0.05599959,-0.09861854,-0.001657219,-0.040872216,-0.02813957,-0.0022481936,-0.06051973,-0.05594972,0.03592134,-0.050684363,0.053729445,0.0057874755,0.039953623,0.009542306,0.011486818,-0.019587895,0.021815524,0.040403806,-2.7397457e-08,-0.053613618,-0.04799801,0.1445046,-0.009181968,0.0041494523,0.048367362,0.07744618,0.090714276,0.009633347,-0.079660736,0.042605102,0.103999585,0.086387515,-0.03227237,0.06600047,-0.01893124,0.02328095,0.029990707,0.011626733,-0.041770153,-0.1467833,-0.07802645,0.010718189,-0.022681417,-0.037845813,-0.026846642,0.06597195,0.035153624,0.028738141,-0.017128913,0.058995567,-0.02167091,0.020333173,0.014611647,-0.019888815,0.040416606,0.018876411,-0.007914484,-0.034849998,-0.019838061,-0.062000364,-0.04372246,-0.102296084,0.08151594,0.10710019,-0.026880983,0.033992033,0.020620659,-0.041832015,-0.015583406,0.019444,0.0025011569,-0.040204715,-0.02914733,-0.045674164,0.07736999,-0.021484671,0.034456674,-0.03079994,-0.012960159,0.007845699,-0.020666094,0.2017649,-0.027286462 +1.1.1.176,"Catalyses the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated form. Also acts on bile alcohols.",384,0.99999994,0.048478696,-0.07704558,-0.039771218,-0.015675366,0.019046621,0.07417706,-0.029883746,-0.012343721,0.029895643,-0.01574031,0.04115585,0.03533269,-0.062028885,-0.056970887,-0.032025557,0.05819618,-0.09238627,0.004985389,-0.05630471,-0.029837517,0.015949981,-0.116360635,0.049666196,0.005279239,0.0368531,0.0687804,0.09990228,-5.8263064e-05,0.029554658,-0.079221986,0.0165225,0.013131712,0.05271151,-0.072997876,-0.068813525,-0.016791144,-0.008525591,-0.020735051,0.0458519,-0.010371495,-0.015003795,0.01824379,-0.03277462,-0.037803147,-0.01411616,-0.015463544,0.059198905,0.05217942,-0.015537136,-0.0018456947,0.029063864,0.024579369,-0.05454593,0.045705806,0.052588522,0.074380726,-0.0812758,-0.04052489,0.002745267,0.009138239,-0.023765158,-0.022097627,0.044220105,0.03181912,-0.06627,-0.06680254,0.044329293,0.003148462,0.015876716,-0.06952835,-0.053344313,-0.07131119,-0.029316906,-0.058186915,-0.05769185,0.015712049,-0.005114485,-0.07229947,0.030570326,-0.0053330623,-0.04756285,-0.027879424,0.015071151,0.14639725,0.1339723,-0.054016255,-0.029537657,-0.05829017,-0.044868488,0.042820033,-0.012672104,-0.027394896,0.004002857,-0.07971482,0.022258816,0.0044978564,0.08227859,0.05157789,0.051405195,0.00048455034,0.036020722,0.10303074,-0.043043025,-0.13783544,-0.08033796,0.06977348,-0.010191785,0.057027332,0.03735958,-0.0396613,0.04608672,-0.049484033,0.0457173,-0.046510965,-0.0582316,0.1434161,0.0205227,-0.081147365,-0.007048843,0.011042187,-0.06476642,0.01585889,-0.0016953512,0.07303175,-0.063915685,-0.0045866673,-0.020220451,-1.3395782e-33,0.021449689,0.022142295,-0.068443835,-0.032512754,0.011354448,-0.030706154,-0.05213585,0.010718853,0.011242948,-0.014385177,0.057528608,0.022963446,0.014731714,-0.034958802,-0.03374517,-0.0070901723,0.013052071,-0.023326883,0.04622648,-0.051830336,-0.052189104,0.025642931,-0.038645074,-0.049217023,-0.011991902,0.036155023,-0.029164586,0.0031170328,-0.021753743,0.028296823,0.024932802,-0.0017851028,-0.09318091,0.09711697,-0.063850835,0.04755346,-0.06193683,-0.0082064,0.018430833,0.026654352,0.07134603,-0.024686852,-0.023742031,-0.03379809,0.0064411596,-0.00325107,-0.029141907,0.05365953,0.13309458,0.043879073,0.034556948,-0.04792445,0.05746138,-0.06489672,0.009629819,0.012074911,-0.0027024595,-0.032172248,0.018198643,0.082758754,0.0014149357,0.0683959,-0.09011918,0.05993179,-0.0051798206,-0.020658597,-0.018501805,0.0029896796,-0.060264662,-0.017584072,-0.05788623,0.10598448,0.07692183,0.0025370757,-0.039180692,0.056099143,-0.017774498,0.008195322,0.0056061763,0.071817525,0.027143002,-0.010488281,-0.02196355,-0.045421485,-0.027505072,0.048802502,-0.01843238,-0.062680095,-0.059221223,0.054259703,-0.03372299,-0.044139415,-0.0377323,0.020499744,0.042313244,-2.3225937e-33,0.030798014,-0.10748895,-0.04811264,-0.08768295,-0.028578196,0.030819379,0.048754327,-0.0501714,0.041812584,-0.035466112,-0.027833465,0.0077715316,0.005880243,-0.04106253,0.015485125,-0.024626609,0.051977847,0.09369155,-0.040036414,-0.073338054,0.0024401254,0.1141982,0.006114733,0.10463645,0.0012015576,0.032014854,0.029716643,-0.023825748,0.081670575,0.17736675,0.011289716,-0.03265203,0.00297193,0.0043996684,-0.038988497,0.04854703,-0.06806438,-0.00734804,-0.030185027,-0.018107032,0.023366673,0.01322747,0.046587452,-0.018294524,0.004738008,0.036142007,-0.05917802,0.008597515,0.003112534,-0.020070942,0.10268293,-0.0014539807,-0.015492819,0.04688946,0.04831752,0.11126444,-0.041412238,-0.061337754,0.019691588,-0.08372582,-0.10819112,0.040276203,0.02123685,-0.04374886,-0.061914627,0.031905785,-0.052119646,-0.042135347,-0.023271834,0.011012389,0.012098772,0.03339361,-0.0285903,0.048276413,-0.0063089444,-0.0018663603,-0.029816544,-0.02883146,-0.014202549,-0.064579435,-0.0039477414,-0.018635767,-0.01725972,-0.0558679,-0.0007813082,-0.06140451,-0.08670443,0.11473794,0.058334712,0.00966766,0.020564197,0.010225925,-0.07718711,0.0009859351,0.0017695314,-2.7161152e-08,0.001284386,-0.071381606,0.08662792,0.082522675,-0.0005166935,0.06905117,0.013707526,-0.026384868,0.016846165,-0.07268401,0.014049546,0.15343526,0.030350842,-0.036973834,-0.0019853506,0.030396532,-0.03532089,-0.037594635,-0.031729612,-0.0876009,-0.07155544,-0.005589198,0.041540593,0.018297479,-0.034394827,-0.057141755,-0.003005953,-0.03242347,-0.016389249,-0.026316846,0.033354387,0.05134847,-0.08809995,-0.052728795,0.0007303701,0.006376772,0.07056259,-0.037168995,0.0053480742,0.021192458,-0.03831689,-0.04460804,-0.098429434,-0.0018680677,-0.029402044,0.0029283501,-0.060106363,0.020126037,-0.030787306,0.06593079,0.039977305,0.022253495,0.01319091,0.026252545,-0.073309824,0.044599175,0.056954935,-0.052331947,-0.0068356753,-0.027898753,0.037396025,0.083032764,0.22253217,-0.019448308 +1.1.1.178,"Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.",384,1.0,-0.0487084,-0.13554072,-0.031039517,0.03073507,0.070095114,-0.028845308,-0.052176632,0.050038587,0.10737728,-0.04863888,0.064116396,-0.017085554,0.02124693,0.044542536,0.016387315,0.041618858,-0.0051843766,-0.0046404894,0.021407515,0.018061021,0.03793638,0.019435281,0.0051064673,0.008225359,-0.0121573,0.11067456,0.0055315015,0.028545493,0.06523371,-0.1175561,-0.0340853,0.0626413,0.0002171944,-0.06191675,-0.009493161,0.053085376,-0.032541335,-0.027513292,0.010910422,0.014536329,0.068597525,-0.07489387,0.03226875,-0.019043887,0.0018746994,-0.01803787,-0.0306546,-0.0022416017,0.051338438,0.020174516,-0.030262697,-0.09220472,-0.07789621,0.050266493,-0.00834597,0.008022785,-0.051090308,0.072653286,0.0019537508,-0.0035340434,-0.038867954,-0.0098647075,-2.7594004e-05,0.06612778,0.070074,0.024337456,0.029074999,-0.037548557,-0.0006461781,0.030538725,-0.045912057,0.027666446,-0.021796504,0.021257034,0.008251296,-0.08607546,0.03046651,-0.05653472,0.016478809,-0.03735114,-0.07477217,-0.017409697,0.012035047,0.087594956,-0.00997408,0.019863527,-0.048190076,-0.10397788,-0.06248038,0.029121408,0.017561713,0.06861452,-0.03770122,0.0059999246,-0.070882335,0.06744157,0.022020087,0.007481136,-0.033487916,0.009780755,-0.029182022,0.06399128,-0.121591024,-0.028181273,-0.0038051442,0.009836951,-0.017345998,0.019118676,-0.047227453,0.08960816,-0.018572781,-0.030992227,0.0030727012,0.03458088,-0.10422246,0.065567,0.018762369,-0.008633711,-0.010450311,-0.006217746,0.03914188,-0.035494167,-0.039682604,-0.046638563,-0.072264105,0.007017004,0.03230953,-9.358474e-34,0.021099789,-0.0013908434,0.0040801885,0.024531197,-0.03847437,-0.020681217,-0.081376396,0.016574254,-0.027050832,-0.0053961566,-0.011398304,-0.049724925,0.018607343,0.07846481,-0.021886611,-0.104944095,0.01408072,0.018625282,0.038350824,-0.055125598,0.013791372,0.056633536,-0.05202231,-0.023609774,-0.012424982,-0.025259653,-0.0036775998,0.04535338,0.024023572,-0.0067274743,0.06064403,-0.02058305,-0.073595196,-0.018483726,0.018124323,0.037019618,-0.02294275,-0.032229606,0.020729484,0.026981622,0.023537518,0.023930041,-0.09176066,-0.026648127,0.03722894,-0.03177344,-0.045820784,0.08646828,0.024659075,0.0495856,0.120268464,-0.027492194,0.090087414,0.01623386,-0.021304313,0.041204266,-0.0010489752,-0.051840976,-0.05767233,0.050301157,-0.008734319,0.009731251,0.021011923,0.038262386,-0.0063279755,0.014949529,-0.11599457,-0.011490356,-0.0038833832,-0.009954234,-0.009890735,0.038605575,0.14317425,0.017383682,0.041666728,-0.023500683,-0.028987238,-0.012997105,0.04254273,0.01713948,0.010109344,-0.055949014,0.07006279,-0.015199807,-0.08485885,-0.013153736,0.03387235,-0.092144184,-0.014804382,0.036646027,0.031083805,-0.08496031,-0.063913345,-0.010214847,-0.0042303144,-2.790125e-34,0.015442438,-0.075058326,0.0453692,-0.039301436,-0.034475718,0.020960774,0.02718994,0.042762905,0.041774932,-0.004039923,0.13613407,0.027411286,-0.07344427,-0.048180565,0.01956564,0.0812927,0.051008876,0.04801286,0.017793892,-0.02158059,0.030268732,0.078229204,0.0302289,0.1277075,0.020933466,0.022338973,-0.025871996,-0.054544795,-0.00066547986,0.12664112,0.0013793195,-0.05012483,-0.048634384,0.011962812,-0.006784779,0.10377133,-0.032991983,-0.008741734,-0.06812132,-0.053020004,-0.05197256,-0.03926031,0.06384006,0.05104836,0.042102795,0.06761001,-0.03521244,-0.003170219,-0.08814189,0.029463494,-0.00061937585,-0.0055844095,-0.054357626,0.11411204,0.08402864,0.036845654,-0.05979517,-0.095228724,-0.012905159,-0.056235787,0.008659379,0.0148336915,-0.060249366,-0.08944458,0.11932531,0.005451632,-0.048675794,0.0028061161,0.136504,-0.015345593,0.0993153,0.042679545,0.020925358,-0.02382035,-0.08437834,-0.11200704,0.006966091,-0.10031281,-0.08633405,-0.054599956,-0.045543462,0.016496954,0.029875103,-0.094541624,-0.17266387,-0.04766735,-0.0364631,0.061836705,-0.011908921,0.037041206,-0.027544975,0.04001657,-0.00020396318,0.077742316,0.030421125,-3.019229e-08,0.0027302231,-0.057225652,0.07141852,-0.019044414,0.016480621,0.09440883,0.0071640075,0.034504782,0.053087577,-0.055955335,-0.014320276,0.06782143,0.08924349,-0.032580387,0.089031115,-0.03307582,-0.020631714,0.021159768,-0.045978475,-0.097182944,-0.09890281,-0.004602164,0.0009812984,-0.020776883,0.006653446,-0.047478907,-0.015313819,0.06219881,0.032690056,-0.017766898,0.049344618,0.005980445,-0.0062081963,-0.014836686,-0.05461295,0.03866018,0.036388334,0.004058038,0.00088719284,0.10458366,-0.026098622,-0.009608859,-0.054824993,0.057029683,-0.011596924,-0.0567646,-0.011466579,0.024683775,0.04387561,-0.058583822,0.035876643,-0.013044417,-0.058859706,0.028812962,-0.040402777,-0.019777453,-0.043154035,-0.008395953,0.0226191,-0.0082174195,-0.0060835667,0.0064878254,0.15818572,0.057965863 +1.1.1.179,"The enzyme, characterized from pig arterial vessels and eye lens, also acts, more slowly, on L-arabinose and D-ribose. cf. EC 1.1.1.424, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming).",384,0.99999994,0.034346938,-0.06622593,-0.029278874,-0.07251126,0.017844781,-0.0011467511,-0.06182936,0.034128036,0.024321672,0.0614963,0.066178806,-0.011174642,-0.071444005,0.071095936,-0.026894478,0.016854573,-0.035946544,-0.01597086,-0.008262338,-0.009934484,0.083771296,0.025049927,-0.014276562,-0.02868988,0.10833362,-0.036226865,0.056403004,-0.040843874,-0.031881362,-0.08400472,-0.0525616,-0.041856784,-0.0079397615,-0.032698918,0.009277868,0.06948766,0.024658073,-0.0103467405,0.033538066,0.052732356,0.029679354,-0.06322387,-0.056676622,-0.015681513,-0.031168072,-0.007349869,-0.022569474,0.07540234,-0.013227516,0.011843617,-0.11136797,-0.06663921,-0.061602958,-0.08754166,0.015611923,-0.00746405,-0.08795483,0.0021674647,-0.034556016,-0.050435133,0.005252798,0.017990107,0.03652425,0.07303786,-0.00031137915,-0.06464817,0.13399968,-0.083200745,0.0218076,-0.046655484,-0.07100506,-0.02923493,-0.02643833,-0.029293409,-0.08725781,-0.048996758,-0.030660028,-0.076659076,0.06739375,-0.05901497,0.06981027,0.048325446,0.000101259015,0.018829044,-0.018186977,0.021777028,-0.0123083005,0.022534564,-0.028313749,-0.008882855,0.0023042348,-0.019977406,-0.06746151,-0.011396798,-0.006281133,-0.022346122,0.05419967,0.061687063,-0.016475862,-0.035716146,0.013618734,0.06866957,0.01446004,0.00100963,-0.040694043,-0.013353709,-0.019410955,0.07433792,-0.0677963,-0.043822393,0.010366143,0.0132563,0.013258725,0.033670805,-0.013285832,0.11066098,-0.012843389,-0.09260521,0.0030890442,0.00078623457,0.052783363,-0.0037738036,0.05939556,0.0778013,0.026150946,0.07345703,-0.067555055,-2.3445547e-33,0.079707034,-0.013424835,-0.019216564,-0.038727686,0.0008941284,-0.007190105,-0.0731879,0.12136599,-0.14061062,0.032295015,-0.07967317,-0.059384875,0.05941678,0.05278872,0.03718911,-0.018548435,0.014095137,0.020339323,0.006918543,-0.015682856,-0.056494348,0.020836223,-0.035417847,0.050916087,0.03096064,0.03462426,-0.01033962,0.0070894337,-0.008588258,0.016598465,4.151345e-05,-0.10688901,-0.040968984,0.040225618,0.019311257,0.0009241869,-0.042962566,-0.044173002,0.030657541,0.0019847408,0.0064349766,0.02464096,0.04416618,-0.056677483,0.022149174,0.019689666,-0.084267855,0.12559164,-0.022946365,0.052079547,0.11249539,0.0030643193,0.07672169,-0.045056466,0.0026903974,0.06597021,-0.065254815,0.04349135,-0.08513301,0.057389993,0.013020563,0.019000068,-0.07815259,0.110934034,0.0021524157,0.015995169,-0.07337226,-0.060767975,-0.018237052,0.027204677,-0.04619362,-0.04215475,0.08428734,-0.06788258,0.04028035,0.011578796,-0.002103405,0.033106778,-0.023880849,-0.008685103,-0.016930906,0.053593054,-0.030540803,-0.0761566,-0.05962678,0.061594754,0.079420485,-0.07195171,-0.02317472,-0.017331777,0.0284673,-0.04011307,-0.076234944,-0.042592864,0.06971195,2.8220488e-34,0.04724062,-0.06529217,0.051801506,-0.015935099,-0.030139877,0.1181157,0.11361036,-0.025855923,0.05475815,-0.051355388,0.07707192,0.020597558,-0.04686045,-0.0721239,0.050872404,0.03250324,0.008854305,-0.053388968,-0.013496735,-0.007514611,-0.024260411,0.10502236,0.05045398,-0.007960933,0.08804822,-0.017451592,-0.0287501,0.0468134,-0.04629846,0.03552462,-0.006373165,0.025341274,-0.030645935,0.009440186,-0.06256253,0.08478791,-0.10228625,0.004615944,-0.008947132,0.062080342,-0.03323118,0.027422473,0.045337573,0.022647424,0.011797978,0.065951444,-0.029643904,-0.04238881,-0.0063850195,-0.04483162,-0.038877703,0.03190737,0.030249054,0.076715164,-0.005207226,0.11006646,0.0050105415,0.06773348,-0.0023246177,0.0024026674,-0.015265489,-0.06597156,0.07041683,0.010599664,0.046742547,-0.039017044,-0.0026894757,-0.046899788,0.08588763,-0.016735455,0.12575383,0.031304788,-0.073058,0.101792365,-0.027963448,-0.030820204,-0.061574254,-0.00986782,-0.08669651,-0.023664853,0.049105532,0.04225192,-0.0057587028,0.012936502,-0.010311165,-0.05666893,0.0037137354,0.12059602,0.02240249,0.029323962,-0.02240353,-0.01914328,-0.07767676,0.0036432047,0.07036564,-3.3767222e-08,0.014597885,-0.06145595,0.043133464,-0.06814944,0.026095493,0.02659689,0.025346417,0.049458604,0.01994139,-0.029981764,-0.020569593,0.1308514,0.012841048,0.05001253,0.04990119,-0.010646779,-0.0110471975,-0.008906675,-0.035991576,-0.0049876184,-0.053180024,-0.020770272,-0.11746694,-0.008751264,-0.035723925,-0.064163946,-0.02603069,0.018181741,0.049197175,0.007355216,0.01960267,0.07314357,0.06878888,-0.07940126,-0.10148451,0.011959618,-0.050813846,0.036544744,-0.024865443,0.0752221,-0.0020899693,-0.08200272,-0.017480146,0.022956066,-0.0022854805,-0.038171526,0.06494193,-0.043267984,0.0078417035,0.020791687,0.025435638,0.04267692,-0.029689552,-0.04646157,-0.058887605,-0.021918898,-0.028332202,-0.067116946,0.014907494,-0.022765674,0.03266291,0.041275762,0.14914186,-0.07145396 +1.1.1.181,"Highly specific for 3beta,7alpha-dihydroxy-C27-steroids with Delta5-double bond.",384,0.99999994,-0.061140154,-0.067806244,-0.09131199,-0.051930007,-0.065192364,-0.01812333,0.008371706,0.014917811,0.004679964,0.0376982,-0.014688585,-0.03170629,-0.15572295,-0.0018072022,0.052266892,-0.053886436,-0.022033932,0.023429286,0.0032090843,-0.0035879475,0.05529964,-0.019584771,0.022552347,0.009386209,-0.0043496457,0.057676397,0.067218095,0.10974756,0.019212525,-0.1155323,-0.019779406,0.002127985,-0.0051501035,0.008400429,-0.04500813,0.017299833,-0.11290499,-0.05654317,0.0036818208,0.05016728,0.056970317,0.008851465,0.024622558,0.029570159,-0.09558247,-0.0577791,-0.12358389,0.04984921,0.086637616,-0.0017817806,0.01402862,-0.12070053,-0.018606761,0.09487009,0.035021413,-0.02084763,-0.09403815,0.021418052,-0.044348255,0.027678315,0.036975212,0.038502995,-0.0024424635,0.0034245707,-0.027436972,0.00433778,-0.04038725,-0.029957725,-0.029369915,0.05566887,0.0024291463,-0.0005359665,-0.0026757491,0.06733801,-0.007508954,0.075723894,-0.0124293445,-0.040748015,-0.0034497266,-0.093167,-0.005354055,-0.018612755,0.05568071,0.14118877,0.058406282,-0.035962064,-0.035593044,0.05613433,-0.015650723,0.004759167,0.022953032,0.1010095,0.0049834494,-0.030755045,-0.0983796,0.1353177,-0.019580541,-0.0052906265,-0.050019596,0.057301886,0.06564218,0.069786295,-0.04690567,-0.011823525,-0.02461404,0.02974064,-0.018594239,-0.005643929,-0.054709215,-0.036675103,-0.011558038,0.017363431,0.05588267,-0.0124872485,-0.10319017,0.019184748,0.0067695267,-0.026128441,0.044407547,-0.10388898,-0.011241367,-0.021007331,0.049809195,-0.05230243,-0.0979018,0.029569408,-0.049805637,-1.5880541e-34,0.07535711,-0.009584028,0.017893001,0.072301984,-0.0750174,0.009530482,-0.028484868,-0.033837702,-0.05812127,-0.055483427,-0.07485502,-0.0010764062,0.07066591,0.01416347,0.008538702,-7.800885e-05,0.028979488,0.047966283,0.097513825,-0.028103925,0.053324282,0.13587913,-0.037006598,0.022195717,0.01834512,0.035414077,-0.0063306927,0.04773843,0.05021486,0.00453604,-0.06324655,0.021856459,0.06897127,-0.0324162,0.042781737,0.021141365,-0.06736708,-0.023250872,-0.023840288,0.056351364,0.12217929,-0.015484916,0.0026978839,-0.018939737,-0.018721342,0.022662802,-0.07478913,0.010531936,0.09195946,-0.0038138237,0.05945788,-0.016882008,0.035473574,0.045925725,-0.031817917,0.07190231,-0.052658897,0.029454654,0.049073093,0.034079127,-0.036422446,0.034627642,-0.057958063,0.041097693,-0.036724545,0.06574294,-0.053286795,-0.034451306,-0.10797345,-0.009739415,-0.0118389195,-0.0566128,0.075555734,-0.010353667,0.06950588,0.08664513,0.023216205,-0.028852599,-0.021296794,-0.0195127,-0.054717716,-0.05096683,0.0050479984,0.03484396,-0.0810764,0.0035661052,0.0036360407,-0.053449504,-0.012564348,-0.008333282,0.006280188,-0.0050946763,-0.06788299,0.007290595,-0.05229989,-2.0888738e-33,0.033124626,-0.06558796,0.06952285,-0.06779034,0.042733718,0.064390615,0.041562956,-0.07393782,0.014445524,-0.020995824,0.096772164,-0.025840662,-0.037673287,-0.090695694,0.008765378,0.020411242,-0.04598529,0.012100438,-0.053050134,-0.02155251,0.028090267,0.08007289,0.0031893416,0.14492759,0.035170875,0.012317242,0.021469511,-0.004249667,-0.021733483,0.067736894,0.0032571561,-0.015991258,0.008208366,0.042139184,-0.06590838,0.014807341,-0.02690572,-0.04921568,-0.013100521,-0.030535178,-0.06939627,-0.012001001,0.029045273,0.04339874,0.0869366,0.007394215,-0.014261802,0.043163806,-0.0041185906,0.02738232,-0.04310956,-0.05929452,-0.03785352,-0.0017183609,0.0106616225,0.002273696,-0.0124143455,-0.04067564,0.114084676,0.015471132,0.037801374,-0.028820215,0.060553722,0.021474281,0.018201593,0.016324092,0.016875485,-0.01412384,-0.017384969,-0.003872675,0.0040955446,-0.009795748,-0.05220164,0.091781415,0.023464497,-0.05353157,-0.036102187,-0.04067647,-0.06310925,0.06444925,-0.03418448,0.0134941405,-0.013927218,0.0030305448,0.010742943,-0.009417542,0.033197075,0.014229671,0.060934097,0.027620835,-0.015050148,0.04016118,-0.0828629,0.018837683,0.04070343,-2.4667822e-08,0.10515285,-0.034926403,-0.00033278635,-0.052471414,-0.07366867,-0.026972272,-0.0189773,0.028313125,0.119834825,0.006565382,0.041277386,0.054390017,0.048290532,0.00693351,-0.030140245,-0.020605214,-0.043427903,-0.0027709624,-0.030128315,-0.0580232,-0.07451629,-0.03488704,0.047072794,-0.04938903,0.031429775,-0.07203729,-0.04837819,0.023615858,-0.014527534,-0.06258329,0.050811756,0.010104292,0.088134974,0.0054052393,0.021859113,0.09628147,0.04103102,0.012830121,0.011673013,0.09301214,-0.035544153,-0.04039836,0.0019436678,0.060788527,-0.03034231,-0.049825627,0.015509295,0.105225705,0.035129093,-0.054896977,-0.04123499,0.026101727,-0.043182604,-0.09589001,-0.09435436,-0.05684739,-0.13481453,0.07349035,0.008419911,-0.09526441,0.027769564,-0.081613794,0.089243814,0.0384624 +1.1.1.183,"Also acts, more slowly on farnesol but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.",384,1.0,-0.03142305,-0.08617095,-0.0436347,0.001624209,0.042185083,0.0056082327,-0.07949154,0.045238502,0.0896068,-0.09893702,0.049897946,-0.05330387,-0.09750211,0.030576494,0.03013796,0.005044055,-0.042963263,0.03200133,-0.03439849,-0.027185315,0.09266948,-0.0032469274,-0.04417512,-0.024015661,0.014648821,-0.023079073,0.021309063,-0.047818925,0.10703877,-0.0723493,0.0060876138,0.04860778,0.007576949,-0.013296115,-0.0022537152,0.0643915,-0.061409134,-0.06679421,0.021908607,0.03879147,0.066735804,0.02699807,-0.0940897,0.055402208,-0.055841368,-0.035557732,-0.03496033,0.010247157,-0.049602907,0.0058662137,-0.13893521,-0.067492194,-0.06600395,-0.010115521,-0.06352484,0.007923043,-0.02493445,-0.0048093456,-0.030177457,0.0034258296,0.038269076,0.043477573,-0.021795359,-0.034042764,-0.020090323,0.050962202,0.04787955,-0.043516003,0.085763015,-0.057076037,-0.0701336,-0.040262837,-0.0069964994,0.02793369,-0.06675381,-0.07064197,-0.0027534491,-0.0068678875,0.0034448942,-0.020894736,-0.007656515,0.040400296,-0.021422297,-0.038405053,0.09251496,0.07447816,-0.046697225,0.069357656,0.021036368,0.018720958,0.051586863,0.015874576,-0.07375142,-0.083182506,0.07171104,0.06809729,0.041013572,-0.00081642135,0.0061849644,-0.044293854,0.037997983,0.045202453,-0.06696868,-0.05064783,-0.072235934,0.06574039,0.034138307,-0.032113537,-0.07227738,0.052251574,-0.038810357,0.03360772,0.10605278,-0.025732845,-0.07668796,0.05302803,0.02861263,0.042097256,-0.04342178,0.031441305,-0.015654936,-0.038153253,0.031690132,0.10490644,0.0016608336,0.044762302,-0.012758617,9.719381e-34,-0.024833683,-0.045761075,-0.012792022,-0.0035788757,-0.06010187,0.046123415,-0.06680798,0.04854498,-0.042210147,-0.03811217,-0.0064810696,-0.045272008,-0.05160734,0.04168864,-0.0086754495,0.012538136,0.03936199,-0.008498078,0.038397238,-0.05618398,-0.011536286,0.11283384,-0.055224705,0.0056423373,-0.06562627,0.062134765,-0.0063881334,-0.0067143743,-0.020909421,-0.039932206,0.003596699,-0.07989882,0.017230395,0.08027512,0.015105427,0.1178712,-0.080838665,-0.008758979,-0.039307456,0.054960944,0.002796884,0.055612065,-0.0154042365,-0.0076984144,-0.006989658,-0.024504632,-0.08325491,0.086230464,0.08098502,-0.03734386,0.040335584,-0.00046906798,-0.017389674,-0.019506773,-0.008698011,0.035460345,-0.019445399,0.041773163,0.03168597,0.0441415,-0.038502377,0.019007834,0.008982265,0.007941048,0.021119053,0.035465904,-0.087919444,-0.020085057,0.016691945,0.058406357,-0.070847474,0.04511608,0.030798567,0.07905886,0.036650192,-0.028068798,-0.046301395,-0.050746664,0.013285101,0.04081799,-0.045669302,-0.018391082,-0.015438494,-0.040070105,-0.020277102,-0.03859451,-0.030610593,0.03821595,-0.014977335,0.0649722,0.037987288,-0.092024,-0.033385366,0.074049674,0.026615739,-3.0076599e-33,-0.010729007,-0.08652451,0.04270459,-0.048169553,-0.041026216,0.088755645,-0.016386416,-0.07465219,-0.052423537,0.0522827,0.043950967,0.033344276,-0.008831177,-0.046510458,-0.0007713322,0.045822173,0.088803135,0.0700951,0.014307083,-0.017803712,-0.029061463,0.091453955,-0.006856621,0.046963245,-0.003863919,0.06545872,0.033393737,0.06664379,-0.022199504,0.06768419,0.07063716,-0.0337012,-0.055786986,-0.09616377,-0.04997144,0.03022514,-0.0843053,0.049250778,-0.032494325,-0.06887122,-0.032565277,0.03081604,0.03335096,0.056074537,0.0017324889,0.046992335,-0.01269127,-0.09783145,-0.029949231,-0.018451452,0.036462717,0.05884531,-0.07567069,0.017304465,0.017640835,0.030035509,-0.06044082,-0.065433964,0.0075645735,-0.04743784,-0.06745876,-0.035630528,0.0001164835,-0.09066407,0.044316757,0.0145994,0.006112471,0.13417883,0.08909961,-0.013263565,0.095160335,0.10720879,-0.03250102,0.069447175,-0.076053366,-0.011415796,0.03966025,-0.10433074,-0.026647447,-0.13227004,-0.006766703,0.012341026,-0.025669169,-0.05591022,-0.09125178,-0.026140755,0.0035644593,0.038530055,0.10262931,0.059947953,0.014632786,0.059203923,-0.03601903,0.022879647,0.14919825,-3.309209e-08,-0.020176351,-0.046911586,0.07896207,0.021664817,-0.03105351,0.01306226,0.015364885,0.046155587,-0.021947857,0.0011401697,-0.039180838,0.014318573,0.01614828,-0.037804503,0.06806377,0.02272009,0.006450721,0.040364422,0.013031054,-0.08129412,-0.0063012554,0.0032503933,-0.049889315,0.021180866,-0.05578247,-0.069715075,0.030296199,0.06142837,-0.0023607176,-0.047105487,0.043825112,0.018673642,0.029998891,0.053809885,-0.052570775,0.0018114009,0.051421177,-0.047323875,-0.042245194,-0.032440662,-0.0005869191,-0.03708173,-0.02974343,0.038208395,-0.022767587,-0.053688087,0.042343993,-0.11350587,0.10882472,0.049755104,0.11543375,-0.002604026,0.027433755,0.0070199533,-0.03490204,-0.010543012,-0.056523044,0.003953906,0.018810922,-0.05789845,0.02526679,-0.016261633,0.13598685,0.01418577 +1.1.1.184,"Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. Si-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)].",384,1.0,-0.0011422054,0.02925847,-0.0058693653,-0.024637453,0.102906056,0.0817406,0.004268349,0.033729207,0.04521162,0.0073873466,0.022302257,-0.06960729,-0.16765533,0.06976066,-0.021490876,0.00044935115,-0.0800314,0.0027960427,-0.03135166,0.002076709,0.03539984,-0.037799675,0.024633333,-0.011384962,0.046894267,0.01617615,0.021383878,0.07833881,-0.015558415,-0.07668094,0.030155756,0.0408772,0.01704281,-0.06842566,0.02829165,0.02569238,-0.049751204,-0.010022596,0.007984418,0.024875216,0.022371136,-0.057969693,-0.013791463,0.038767304,0.005081502,0.00094893173,-0.017325819,0.11479553,-0.047065575,0.012013471,-0.038461402,0.00054971216,0.009981436,0.081695914,0.041855212,-0.03059246,0.026730698,0.059385583,-0.01440828,0.033807017,-0.0041054306,-0.059866004,-0.04101824,0.028253088,0.017432826,0.012888228,0.07157745,-0.08003294,0.010020939,-0.019100511,-0.073885,-0.05115225,0.011731003,0.027851202,0.063865624,0.015985575,-0.06999339,-0.010908435,0.04991977,-0.03344972,0.02090879,0.06933557,-0.0040540346,0.032817416,0.09576382,0.040307358,-0.06897234,-0.03379541,-0.03215539,0.016955303,-0.069688305,-0.065181255,-0.032296628,-0.06483928,-0.055532403,0.07847635,0.09185009,-0.013591433,0.038222082,0.017847564,-0.00034615738,0.09823692,-0.066008486,-0.07036389,-0.08103712,0.03978995,0.02840588,0.08237264,-0.06627372,0.005380888,-0.031799868,-0.009738712,0.04512006,-0.04034923,-0.019658122,0.071199924,0.088607915,0.017876074,-0.01874115,-0.04581912,-0.055201206,-0.001377071,0.0090689445,0.034350604,-0.041597765,0.063471675,-0.10393323,3.367372e-33,0.10513998,0.045926582,-0.07048921,-0.007388812,0.069944836,-0.06262409,-0.10763467,-0.0037772767,-0.0667764,-0.05052346,-0.004047915,-0.051287293,0.014321923,0.0052625984,0.05647849,0.0040508863,0.0064928336,-0.04494032,0.021725364,-0.099202834,-0.0027424404,0.09104482,-0.06764545,0.031594373,0.03704852,0.03984418,-0.048009034,0.08914988,-0.071630746,-0.015565841,0.003074675,-0.012192935,-0.079994306,-0.0072178384,0.01695018,0.0031464188,-0.13061446,-0.028025929,0.008387067,0.024386086,-0.0056223916,0.12330387,-0.0051252544,-0.047760323,0.0072220806,-0.04003099,-0.0020586927,0.08122783,0.03345294,0.0046676765,0.06403659,-0.045314252,0.051097427,-0.06896478,-0.07130119,0.08266478,-0.009358869,-0.06232668,0.015423808,0.029318588,0.036432132,-0.021850375,-0.009720798,0.035448868,-0.0047403546,-0.048031803,-0.09595156,-0.044183776,0.030738229,0.019017251,-0.042750176,0.064974986,0.10722864,-0.068583675,-0.036083058,0.015502776,-0.017356023,-0.060318623,0.053750712,0.0376539,-0.03682712,-0.032151464,0.010353985,-0.07958686,-0.060517885,-0.021364747,0.00068303075,-0.039200056,0.022144627,-0.042267688,-0.026856307,-0.0749137,-0.02156267,-0.07224737,0.024685726,-4.7006002e-33,0.099442825,-0.0037591374,0.07948991,-0.050573897,-0.03086595,0.07728311,0.024242572,-0.12227611,-7.039396e-05,-0.026682625,0.05771655,-0.01901613,0.053836983,-0.08810995,0.011695703,-0.0013012112,-0.01168192,0.020550804,0.03475321,0.00058686815,0.04566971,0.079075724,-0.011522828,-0.011057287,0.043535035,-0.049051996,-0.023704635,0.051495675,0.017735844,0.01466098,-0.010649105,-0.027782163,-0.050016943,-0.03962762,0.05793646,0.03314134,-0.049827132,0.03797273,-0.050725814,0.034597397,0.03718686,-0.044310387,-0.06653179,0.051542632,0.038971134,0.06763145,-0.082253456,-0.009760544,-0.012888862,-0.05929627,0.05811535,0.028013833,-0.06886239,0.033337623,0.03459692,0.08419588,0.009944068,-0.02984622,-0.026412548,-0.0149419885,-0.053390097,-0.013379085,0.02593715,-0.008038103,0.027381843,0.008343183,-0.078639485,0.044633586,0.057771128,-0.06449155,0.110837586,-0.0047103097,0.050850105,0.06693253,-0.11965373,-0.18758266,-0.029862849,-0.015790261,-0.052368473,0.01607152,0.027928047,0.007916023,-0.044346113,-0.0065237973,-0.038935125,0.026324458,0.015501889,0.05086169,-0.023762558,0.03705236,0.013598363,0.11578698,-0.031550348,0.07953654,-0.008888443,-4.343341e-08,0.033416938,-0.0060530687,0.03488926,0.02041932,-0.0477767,-0.029659389,0.07408677,0.011106042,-0.011579767,0.011926503,-0.0022082971,0.10642234,0.07471753,0.009202657,0.08952029,-0.0426019,-0.051209033,0.0025685937,-0.065851584,-0.033087138,-0.018834565,-0.0013360154,-0.02839646,0.042403936,-0.0069243675,-0.08053178,-0.0012173298,-0.0022500576,0.029792733,-0.001490562,-0.017233444,0.05304609,0.026638646,-0.01999931,-0.005806132,0.066558905,-0.02280488,-0.034220595,-0.06037176,0.05438175,0.018315073,-0.09330359,-0.08120186,0.037854955,0.018318595,0.012367518,-0.00071682123,0.018682508,-0.017830111,0.060856335,0.058990102,0.05856029,0.02889755,0.04013935,-0.07386471,0.059143983,-0.043440975,-0.012168154,0.032571286,-0.07827608,0.115294136,-0.029464226,0.15214029,-0.017767223 +1.1.1.185,"The 2-hydroxycarbonyl compound formed can be further oxidized to a vicinal dicarbonyl compound. In the reverse direction, vicinal diketones, glyceraldehyde, glyoxal, methylglyoxal, 2-oxo-hydroxyketones and 2-ketoacid esters can be reduced.",384,1.0,0.040031593,0.022053832,0.083269686,0.004627863,-0.031113358,-0.013849146,-0.07369154,-0.01163477,0.017963054,-0.010722171,0.027483273,-0.0035361208,-0.073147826,-0.022726,-0.013865404,0.053723056,-0.02675427,0.11709306,-0.028633121,0.05515109,0.03485895,0.0071468465,-0.020576268,0.075442754,0.0027046637,0.070267044,-0.030592488,0.097744614,0.026814966,-0.1156937,0.07350185,0.0376074,-0.038384788,-0.05798332,-0.02392524,0.017756784,-0.031169767,0.0703164,0.06547576,0.02592669,-0.020646036,-0.034084164,-0.035241634,0.010608763,0.011697835,-0.024476359,-0.03564515,-0.0008705164,0.031134661,0.0037299367,0.020316476,-0.012843051,-0.081752494,0.09375469,0.03140798,-0.037772693,-0.10612909,0.055637278,0.012796466,0.0050054695,0.0108314315,0.05248463,-0.054657128,0.017144646,-0.06495124,-0.02919905,0.07821678,-0.10399899,0.026316825,-0.018591346,-0.019301934,-0.08901116,0.06272678,-0.04066624,-0.02675143,0.015369244,-0.0070343954,0.015794635,0.07074933,-0.050398123,0.07534237,-0.0037688417,0.05127141,0.082428254,-0.017205771,0.003925352,-0.04427545,-0.08975743,0.04443573,0.03009473,0.028848484,0.022916988,0.06268469,0.00085265876,0.0045108735,0.014660589,0.08472075,0.068617925,0.027423084,0.06469649,-0.024562513,-0.005863735,-0.07894827,-0.110897414,-0.07533337,0.023567129,-0.006655579,0.005065868,-0.01824228,-0.052998696,-0.009963733,0.10306058,0.0076321242,-0.04604569,-0.10944717,0.076995924,-0.00049440877,-0.049248282,0.007822464,-0.03009163,-0.015620747,-0.03781599,0.032527283,-0.016836017,-0.06597875,-0.017074471,-0.011963767,4.993229e-33,0.024433713,0.045730576,0.057762668,-0.011266297,0.025876822,0.012358457,-0.08060734,0.01145703,0.033772618,-0.06144016,-0.06752938,0.033889916,-0.05915472,0.07896075,-0.001380858,-0.06861396,-0.0052513634,-0.0057238033,0.061228976,-0.13121058,-0.027419502,0.078075334,-0.029621677,-0.015227706,-0.025872746,0.0077271806,-0.01688152,-0.040250935,0.018379856,0.022133712,-0.015226572,-0.0028872355,-0.045907345,0.025530195,-0.07965052,0.0675329,-0.09720387,-0.0011843515,0.019391743,0.079265684,-0.003170871,0.033350617,-0.036479395,-0.07007737,-0.005420011,-0.06398874,-0.01016211,0.04269589,0.06040113,0.06803919,0.07546743,-0.029782375,-0.06660788,-0.025091061,-0.06970501,0.034664582,-0.0059925243,-0.05922305,0.015022386,0.04687044,0.008240112,0.041108068,-0.0069668475,-0.024150336,-0.014082013,-0.046696402,-0.052979495,0.006802775,-0.06847577,-0.030187378,-0.056584764,0.01932659,0.12670568,-0.03211723,-0.0017743671,-0.019863348,-0.024482924,0.06104524,0.07341019,-0.01628946,-0.029145075,-0.01848391,-0.046781622,-0.00022012304,0.031406395,0.051958486,-0.011640576,-0.022488067,0.04110555,0.07680989,-0.0686105,-0.0753457,-0.014047803,-0.047269125,0.05376982,-6.843e-33,0.04045939,0.00689924,-0.003384184,-0.008363324,-0.017987782,0.05562567,0.06532377,-0.029552888,-0.027817851,0.007973667,0.016414454,0.022149673,0.07300111,-0.041417636,-0.021172017,0.003964352,0.04716091,0.06663239,-0.059805125,-0.0772226,0.035451096,0.036490694,-0.06444687,-0.0064239777,0.068700425,-0.027555212,0.0019102602,0.07432555,0.10710857,0.063897766,-0.008425015,0.038731474,0.040643968,0.0069876453,0.04072926,0.07932259,-0.08235811,0.0010003314,-0.0901872,0.019750074,-0.07109929,0.0033901935,-0.0076397643,0.065865114,0.07766789,0.06519382,-0.103031725,-0.04761037,0.08063739,-0.03911042,0.07934863,0.027084999,-0.07722813,0.033182032,0.0066825356,0.037685197,-0.030392326,-0.037683044,0.058582403,0.01113696,-0.040816348,-0.019426167,-0.012494623,-0.09857023,0.04336403,0.022548195,-0.045605905,0.009969596,-0.005367807,-0.007886768,0.06432163,-0.0038918077,0.022653952,-0.040784154,0.013877264,-0.06797433,0.008571431,-0.062398363,-0.07415474,-0.048147816,0.12599932,-0.0153517695,0.05588455,-0.055510633,-0.10842416,0.0023164724,-0.05045006,0.056928426,-0.02405085,0.042865675,0.0031438244,0.044073526,-0.014417145,0.06678177,0.08214138,-4.2432266e-08,-0.009102733,-0.10045833,0.08229512,0.04949095,-0.022610076,0.06274124,0.025713492,0.10796598,-0.005602753,-0.130029,0.0030408327,0.053883646,0.035154037,0.029473467,0.000112813395,0.03874113,-0.0669299,-0.012576603,-0.026422227,-0.011916334,-0.06178451,-0.030956026,0.024919704,0.032511428,0.0037701959,-0.078904055,0.025833491,-0.014913774,-0.013785127,0.00240183,0.048019856,0.06399592,-0.027022604,-0.06124842,-0.08153725,-0.05452755,-0.023162598,-0.03072416,-0.06290378,0.016309053,-0.014498858,-0.07945771,-0.07409489,0.06258942,0.083999805,-0.05856859,0.027466834,-0.002612294,-0.042492375,-0.01542479,0.07364035,0.025865847,-0.013921811,-0.03449367,-0.10899661,0.014829407,-0.034823295,0.06955384,-0.056076117,-0.119081855,-0.03208233,-0.004318119,0.17423451,-0.012368856 +1.1.1.187,"The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-alpha-D-rhamnose and its C-4 epimer, GDP-6-deoxy-alpha-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase.",384,0.99999994,0.0004702783,-0.018338885,-0.09159407,-0.034730792,0.063300654,0.041568246,-0.031824782,0.020164464,-0.018088393,-0.0039464673,0.020748587,-0.028017819,-0.08187359,-0.018045323,-0.068575,-0.011687915,-0.07470212,0.0014336117,-0.02006047,-0.0625591,0.029990992,-0.0267187,-0.008839269,-0.0033772162,0.068066195,-0.010191316,0.089176916,-0.047238205,-0.03581422,-0.108917125,0.03692038,-0.053267222,0.045638874,-0.0023476689,0.02323865,0.100099176,0.013661406,0.0035474966,0.011004361,0.050323248,0.024437835,-0.0064136926,-0.037148982,-0.015279865,-0.0850408,-0.014517406,-0.0953782,0.09925409,0.0408719,0.004796885,0.0066374335,-0.05644936,-0.083743244,0.056418326,0.015648048,0.019097961,-0.026897473,0.008445139,-0.053536184,0.035835173,0.06034334,-0.022149721,-0.002074426,0.013787817,0.07534583,-0.032335937,0.089135826,-0.039838795,-0.032189034,-0.07000332,-0.02110312,-0.06256235,-0.044596344,-0.037167937,-0.06881079,0.01752712,-0.0034677582,-0.072718255,0.05660209,-0.004745975,0.04449615,0.07606075,0.06521908,0.011219239,0.04197479,-0.01058015,-0.019722998,-0.028851911,0.052001175,0.038302097,0.027737012,-0.015333621,-0.047988344,-0.02374025,-0.019889474,0.065127045,0.009068985,0.06646744,0.081750594,-0.052381475,-0.02659071,0.071810275,-0.062346525,-0.09391641,-0.093838535,0.020802487,-0.02986049,0.0898208,-0.0043837675,0.044349417,0.01991422,0.036066215,0.08322967,0.04760236,-0.07025219,0.033125486,-0.032117102,-0.06707013,-0.03627945,-0.0015352946,0.053993907,0.051913243,0.08537554,0.062915996,0.036880597,0.013100381,-0.03983108,-2.0052209e-33,0.022945974,0.00826482,0.005095817,-0.0138587095,0.019633418,0.05916905,-0.105168834,0.06812495,-0.06450529,0.039361365,-0.09852098,-0.010852501,0.029388359,0.015459926,-0.0055260924,-0.011787735,0.035544146,0.031581663,0.01833072,0.027728789,-0.008086785,0.08211073,-0.05312736,-0.0171274,0.027899474,0.07844045,-0.06707631,0.0473011,0.0510111,-0.011896893,0.020834992,-0.07154388,-0.08824936,0.023348546,0.022537796,-0.023026068,-0.05106854,0.005125745,-0.052887075,0.046130765,0.021820145,-0.0022755873,-0.002454873,-0.061901003,0.035067104,-0.09938152,-0.0074015195,0.056322858,0.050770793,0.07904454,-0.013836279,-0.005749073,0.079869755,-0.051059794,-0.05686,0.011128796,-0.0866845,-0.027936738,0.081121504,0.06380012,0.0154878665,0.10810462,-0.056310058,0.0026010796,0.04714034,-0.03288411,-0.016984532,-0.054106396,-0.03309806,0.092456184,-0.03947558,-0.04938833,0.10397562,0.010642525,0.049358826,-0.052204512,-0.022302974,0.017451018,0.011705208,-0.054799955,-0.074394375,0.01954362,-0.016877128,-0.014719127,-0.031270698,0.014906894,-0.051746998,-0.029330129,0.012330759,0.018558403,-0.020620242,-0.08357106,-0.13575664,-0.011027012,0.03444346,-7.952352e-34,0.076005325,-0.057368685,0.024207916,-0.079572394,-0.01835636,0.10922824,0.13992938,-0.000115847404,0.029684229,0.0024420277,0.12928563,-0.033635553,-0.05548246,-0.05190987,0.063498974,0.08120772,-0.015269607,0.08554055,0.003071555,-0.01536996,-0.05584455,0.08739753,-0.018478293,0.060689233,0.04092331,-0.025932249,0.04015528,0.07447685,0.07565722,0.040195473,0.0017722957,-0.0063405656,0.02392675,0.034025434,-0.082890674,0.06270021,-0.06470972,-0.006132635,0.0068361787,0.026612658,-0.029577201,0.08021514,-0.025736134,0.07994619,0.063398086,0.05417684,-0.097872704,0.043727126,0.0009099521,-0.06654063,0.07127792,-0.0010995248,-0.014790304,0.0060869567,-0.024711942,0.019315748,-0.008556734,-0.02645259,-0.059940778,-0.014189261,-0.0204634,-0.09351956,0.05266975,0.012870764,0.016204335,-0.016005145,-0.035022605,-0.0044768,0.04348955,0.010462223,0.053954244,-0.017926952,-0.025658432,0.0152872335,-0.019415082,-0.050735988,-0.057258952,-0.04460696,0.03012896,-0.0056788516,0.006725419,0.02486158,-0.00018560709,-0.06748484,0.010570285,-0.050377436,0.0030866931,0.076236464,0.019923784,0.061205152,-0.053416815,-0.036614507,-0.07371313,0.076722786,0.10221231,-4.610489e-08,0.09074504,-0.07418021,0.097893454,-0.060002718,0.05743598,-0.013719108,0.029516863,0.004318401,-0.0027013286,-0.034849253,-0.005511832,0.10156565,-0.042387083,-0.012001581,0.052054062,0.0103394855,-0.06749909,0.03787223,-0.040226694,0.02658718,-0.009420015,-0.0074440395,-0.1371546,-0.0038631826,0.051603932,-0.0162975,0.03075404,0.043084145,-0.040706053,0.03647095,0.046199556,0.023174739,0.035339534,-0.05059634,-0.100630656,-0.027171694,-0.026424807,0.006743979,-0.05965457,-0.018008973,-0.0009718222,-0.09752383,-0.047444,-0.0047311117,-0.029945472,-0.005012899,-0.024646893,-0.049351286,0.021081077,0.013350546,0.038497917,-0.0041488507,-0.01646194,-0.044990957,-0.043781154,-0.009821761,-0.039009135,-0.08947249,-0.023278013,-0.08566324,0.0778929,0.017084712,0.17737712,-0.04618126 +1.1.1.188,"Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.",384,1.0,-0.03081931,0.06471243,-0.018096667,-0.04138874,0.06759919,0.07146733,-0.05810274,0.06729467,-0.022205075,0.019063544,-0.015690364,0.03648378,-0.07183677,0.0251356,-0.018853975,0.012933969,-0.055575922,0.056874316,-0.038897786,-0.033088896,0.016532777,-0.06746873,0.03185147,0.0021688046,0.058271874,-0.0075580673,0.0071989624,0.035282727,0.027064005,0.013333871,0.04757877,-0.06502115,-0.07198009,-0.0020186347,-0.0016088057,0.021561932,-0.03939591,0.02643338,0.018100517,0.03799357,0.030811446,-0.031815182,-0.06964637,-0.04483588,-0.0138264615,0.04932081,-0.051098157,0.06290422,-0.018666307,-0.02769445,-0.060546417,-0.009261683,-0.05644475,0.06312988,0.021751225,0.021594873,-0.027473722,0.015186365,0.025657585,0.042997107,0.027575003,-0.010622457,-0.06477468,-0.001087081,0.01607953,-0.038364816,0.021011386,-0.056163777,-0.04313783,0.055321123,0.0196731,0.0007165222,0.004689993,-0.074495606,0.04221116,0.013785879,-0.04297055,-0.08581499,-0.021912696,-0.09636269,0.07712151,0.02712423,0.06649536,0.08265741,-0.026998037,-0.006143396,-0.019068198,-0.08208708,-0.043061715,-0.020515032,-0.0063268873,0.010888891,0.0286584,-0.011386959,-0.08967046,0.04767237,0.049550723,0.0211204,0.008188956,0.04808904,-0.053085946,0.01984776,-0.12371492,-0.19786955,-0.10865233,0.054151174,0.016148675,0.064200126,0.021780305,-0.021729935,-0.0027119843,0.0007526396,-0.030871008,0.042182993,-0.029284725,0.109802075,0.07853469,-0.01484264,-0.0349853,-0.009106707,-0.0006291145,-0.021854509,0.10836199,0.0024162582,-0.078082494,0.017292526,0.008358335,8.506783e-33,0.061589237,-0.010753521,-0.028812261,-0.023250997,0.026108535,0.021919599,-0.15810862,0.010524757,0.0007268458,-0.061708853,-0.08942938,-0.07532395,-0.02305361,0.013312437,0.0022500562,-0.10160054,0.10730876,0.013119902,0.053916436,-0.05287898,0.006790453,0.08723259,-0.015181477,0.045598265,0.04345521,0.07318447,0.03839631,0.064321406,-0.026530309,-0.02182889,-0.009857369,-0.040942907,-0.06445351,0.059660777,0.024428524,-0.007053302,-0.09691709,-0.03862498,0.0035610138,-0.011798585,-0.027727732,0.0154488245,-0.06055561,-0.06445834,0.058444604,-0.065332934,0.0426262,0.032667257,0.023964915,0.056808736,0.056922957,0.07783315,0.056079328,0.011585149,-0.06550288,-0.017974213,0.03134422,-0.062686376,0.074171565,0.049193777,-0.021866044,0.03004527,0.013520838,-0.022275593,0.033947185,0.037004024,-0.07136941,-0.02108566,-0.05366009,-0.0040081916,-0.037627738,0.039670855,0.16244857,0.039034706,0.1051262,0.0017968703,0.012381902,-0.04508472,0.00254229,-0.06633709,-0.056507666,0.045662705,0.021875342,0.033161465,-0.024954582,-0.019036638,-0.0598232,-0.07336927,0.02957171,0.04105722,-0.07468701,-0.09516679,-0.08406619,-0.030980317,0.11083642,-8.295831e-33,0.0009223902,-0.0017046733,0.009334421,-0.05851168,-0.045347143,0.056234445,0.02341399,-0.09852799,-0.024299607,0.008964309,0.083958395,-0.034428995,0.02472417,0.0031469704,-0.033983912,-0.017192468,-0.032221437,0.03563019,-0.01742277,-0.017913992,0.070476666,0.07584793,-0.06645738,0.021504397,0.053998098,0.047856014,0.020270167,0.071952045,0.10180175,0.098917305,-0.016768198,0.02443255,-0.102276444,-0.067162685,-0.001983138,0.03975328,-0.03297525,0.034504145,-0.0927593,-0.00017811025,0.034297306,-0.030720597,0.027677828,0.030425256,0.08397864,0.075001515,-0.03725465,0.015639154,-0.049846586,-0.024466455,0.005452216,0.07285294,-0.030337935,-0.023213105,0.08320975,0.014573396,0.07598532,-0.033646584,-0.009094739,-0.030581322,-0.021322593,-0.024811324,0.04153491,0.017035445,0.045186333,-0.00053010485,-0.018615322,0.061327826,0.087306164,-0.047048338,0.071777016,0.00030666002,0.054385286,-0.003671042,-0.028932843,0.00075272773,0.0032305676,-0.07902016,0.026136093,-0.014650378,0.030678473,-0.038724214,0.01894285,-0.08119488,-0.070713475,-0.015322241,-0.021708248,0.038164105,-0.050796676,0.04169554,0.012938449,0.107429676,0.03693256,0.013527648,0.006580984,-4.0033846e-08,0.056692403,-0.041023687,0.1051696,-0.028549265,-0.013853483,-0.06876163,0.0116192885,0.077331685,-0.010821757,-0.072890595,-0.027720653,0.07696871,0.04079231,-0.03428147,-0.0011359737,0.0018244564,0.0014416206,-0.07054609,-0.0413481,-0.012166258,-0.0661616,-0.016405074,-0.10923711,-0.014632354,-0.040916998,-0.0784846,0.06945364,0.03870454,-0.007512381,-0.045845352,0.08071179,0.03895128,0.01059638,-0.06315705,0.04955637,0.04086639,0.010085584,0.046862144,-0.019617377,-0.07487355,-0.02501254,-0.030367456,-0.017093765,0.09435828,-0.008784564,-0.014252578,0.03851502,-0.021618951,0.0013845057,0.02689093,-0.057711184,0.0006106941,0.014472368,-0.06638032,-0.11270651,0.058720466,0.006887703,0.0015717195,-0.062041104,-0.077618405,0.0109793665,-0.03301456,0.14233454,0.0160462 +1.1.1.189,Reduces prostaglandin E2 to prostaglandin F2alpha. A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. May be identical with EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).,384,1.0,-0.06688846,0.081716925,0.015234525,-0.06424977,0.08778304,0.028945854,-0.06942131,0.11517858,0.023476792,0.0023016497,-0.0046603694,-0.016167827,-0.084516235,-0.0023854575,-0.022224268,0.020269748,-0.017228635,0.032599285,-0.020058421,-0.059696406,0.012972719,-0.043279506,0.016281113,0.025447963,0.02112964,0.022027496,0.023526458,0.07491863,-0.04361267,-0.05809054,0.08793242,-0.046902724,-0.024498675,-0.058495015,-0.037935928,0.06814454,-0.05543038,-0.058473248,0.0075919153,0.027052423,0.028259568,-0.01010713,-0.09447236,-0.048208836,-0.026794065,-0.04110822,-0.021349786,0.08106243,0.022343868,0.017666182,0.012595726,-0.0167015,-0.06340049,0.014475524,0.05045655,-0.084924616,-0.03859337,-0.0027711226,-0.034762148,0.04026141,-0.029454213,-0.05866301,-0.028289357,0.049255867,0.0028851111,-0.023284415,0.07826999,-0.09537124,-0.038967587,0.05006914,-0.07277419,0.014717841,0.0841783,0.0024775455,-0.038264304,0.07854598,-0.07389418,-0.096184805,-0.0017985848,-0.02343943,0.054058526,0.029380716,-0.0074422304,0.070365705,0.016804572,-0.04113607,0.009839055,-0.0825123,-0.04350786,0.022420356,0.017048826,-0.024224197,0.027165348,0.064456694,-0.060596433,0.055486016,0.04227342,0.010838223,-0.03923156,-0.0043954523,-0.073231675,0.08838197,-0.04883587,-0.114841,-0.055421274,0.0034499383,0.027888242,0.08721769,-0.004902489,-0.019300895,-0.007786511,-0.06696409,-0.022151407,0.010941042,-0.047747362,0.122025274,0.009131356,-0.03889874,-0.031433173,-0.057951257,0.04568761,-0.036165506,0.04690095,0.020121645,-0.058827333,0.026087724,-0.0591807,5.6722095e-33,0.050483532,0.006004389,-0.055061456,-0.0068208906,0.043682717,0.058122773,-0.11876325,0.045854304,0.012119028,-0.04911983,-0.06849065,0.03157906,0.043953676,0.00016699088,-0.032990117,-0.12204441,0.043433808,0.003967947,0.065538846,-0.010707048,0.016836636,0.05623168,-0.0020515241,0.012200046,0.013574594,0.04517949,-0.013485588,0.079772964,-0.021340922,-0.0020286334,0.02680311,-0.080101274,-0.13230866,0.06551979,0.029665822,-0.0076531405,-0.033534154,-0.05175085,0.057685476,0.04686588,-0.02421541,0.050276563,-0.027723553,-0.061033025,0.07690399,-0.07477228,0.0046095466,0.060491532,0.06246178,0.03043139,0.07113308,0.042971883,0.035486273,-0.07868903,-0.04129908,0.0072012427,-0.034721512,-0.0007705637,0.05667208,0.07168618,0.0016816306,0.07420442,0.01728557,-0.019779688,0.006969884,-0.0012418316,-0.04547909,-0.073822185,-0.04725612,0.030895846,0.011393964,0.09292069,0.1871408,0.0126638245,0.054022335,-0.006139564,0.03872816,0.033285055,-0.0016516033,0.022970896,-0.036358595,0.051423825,-0.027663887,0.029152919,-0.009718147,0.03117003,-0.026670175,0.00012736105,0.05872806,0.045298345,-0.0018230558,-0.114885755,-0.06207077,-0.05860699,0.077895604,-6.0113826e-33,0.03972941,-0.006654079,0.013162664,-0.07649403,-0.010765447,0.0824635,0.1034162,-0.046216317,-0.011682771,0.0050407536,0.11280879,0.0039134556,0.033009205,-0.063156396,0.0065057585,-0.033298537,-0.08408871,0.016362105,-0.05192385,0.0029537426,0.07378463,0.07411769,-0.015201252,0.038840786,0.07678362,0.008826047,0.015098104,0.03154742,0.01693706,0.06534323,-0.04952855,0.04200836,-0.10615188,-0.019843237,-0.0055239196,0.0607645,-0.057752922,0.03767358,-0.061887953,-0.0013817,0.0009180633,-0.0135627175,0.04139984,0.0029355686,0.094318084,0.087152034,-0.06344391,-0.014037816,-0.007270827,-0.021788253,-0.04245024,0.08654593,-0.09753197,-0.011132715,0.03866594,0.0015862875,0.021047877,-0.010502923,0.043789603,-0.0004775122,0.015907105,-0.020003596,0.06507659,0.017207375,-0.00831816,0.011231267,0.008625236,-0.019674134,0.069462664,0.030422082,0.080966316,-0.0728535,0.02423088,-0.01525818,0.028954457,-0.023470378,-0.019983478,-0.040109254,-0.06586161,-0.0054958323,0.0963742,-0.009710613,0.008483003,-0.075275585,-0.04469213,0.028867899,-0.04945082,0.0499977,-0.04241484,0.055821877,0.0038959668,0.051856138,-0.059365623,-0.0011067948,0.009411771,-3.811737e-08,0.0055815578,-0.060099285,0.13030696,0.0077765067,0.02055297,-0.06099489,-0.029929861,0.04906529,0.018866096,-0.07212501,-0.0040008454,0.1292786,0.026171986,-0.0045668324,-0.0069280844,-0.031361286,0.0026039176,0.013399488,-0.011620251,-0.0047078435,-0.073096566,-0.013222866,-0.08606934,0.027618112,0.008189332,-0.053893283,0.015035124,-0.049293913,0.060329776,-0.062273953,0.05911096,0.021791684,0.04239252,-0.051568475,0.002265898,0.031654105,-0.010871874,0.08681742,-0.08851906,0.040938936,-0.06163394,-0.12945303,0.01952717,0.045226805,0.040412102,0.024041178,0.05205411,-0.01174287,-0.025546584,-0.0017841865,0.0068649817,-0.034412686,-0.002016291,-0.054330166,-0.10452703,0.0057208915,-0.044212483,-0.061429113,-0.06344116,-0.042467758,-0.007971094,-0.04250366,0.1481257,-0.02285627 +1.1.1.192,Hexadecanol is a good substrate.,384,0.99999994,-0.01761533,-0.031451236,-0.01176026,0.011314688,-0.015259512,-0.034330446,-0.030661909,0.07092977,-0.07151368,-0.032323804,0.022346763,-0.07042276,-0.043422136,0.06995252,0.0027061868,-0.016829036,0.030263802,0.032881342,0.06384733,0.01712856,0.05346791,-0.03394893,-0.010093844,-0.04180441,-0.02945784,0.04342335,0.0032207172,-0.015804393,0.052982736,-0.16148274,0.021531446,0.04352704,-0.017619632,-0.11135265,-0.019613061,0.058881734,-0.026702072,-0.0125885,-0.048949692,-0.032587934,0.011858464,-0.010840773,0.03768367,0.0010732794,-0.054541823,-0.06688037,0.032277096,0.0033147694,0.09887239,-0.067673385,0.031492583,-0.07038264,0.043103833,-0.02591574,-0.0073240604,-0.050100625,-0.046110734,-0.02744345,0.05089548,-0.03141231,0.07064421,0.038106732,-0.05221065,0.020812174,0.04466827,0.030537063,0.03320303,0.010976977,-0.009774523,0.05505954,-0.067417055,-0.002758887,0.022626068,0.05806689,0.036168803,0.12752911,0.04474429,-0.107681,0.039681245,0.07517901,-0.067811735,0.09411094,-0.02729469,0.04429228,0.105433725,0.08761924,-0.025980385,-0.04088255,-0.032079738,0.02774134,0.020668995,0.09968687,-0.025007408,-0.034491263,-0.035326887,0.0211479,0.038670406,0.039136462,-0.010777228,0.009683403,0.043590292,0.036712904,-0.0792748,-0.027715726,-0.07009253,0.012747098,-0.034767304,0.07586379,0.0021347294,-0.02762544,-0.034520056,0.0020949333,-0.03633575,-0.055179436,-0.037939847,0.027135564,0.02849736,-0.003401992,-0.008520349,0.0040157405,-0.052053403,-0.02971032,0.0029190215,0.079841666,0.041208766,-0.098516166,0.004874801,-1.5116495e-33,0.03353134,0.06998384,-0.05252237,0.034359377,-0.016841255,-0.025535058,-0.07581698,-0.06972241,-0.04538581,-0.05438249,-0.073952906,-0.0025357336,-0.10199867,0.096237935,0.05197194,-0.11983589,-0.066511616,0.0030024464,0.0333134,-0.026604628,-0.012104232,-0.0069844713,-0.050676446,-0.025040062,0.103220336,-0.030166565,0.005196414,-0.041784443,-0.046485152,0.020457307,0.008407097,0.021536514,0.010653897,0.046635833,-0.039120533,0.045928877,-0.123465516,-0.010122418,-0.03546583,0.022651732,0.04428054,0.092588134,0.047087036,0.04263029,0.08923425,-0.04940686,-0.0040446646,0.030640552,-0.02504471,-0.049172074,0.011246382,0.041963525,0.05483242,-0.04024848,-0.02015678,0.04688373,0.07268413,0.020308338,0.06930751,0.10600879,-0.07867661,0.14062123,-0.04649695,0.06860345,-0.0049229683,0.028305996,-0.011149094,-0.01613894,-0.09706833,-0.044176716,-0.041161995,0.016130434,0.11274382,0.023202939,-0.016825581,-0.0075775026,-0.083276734,0.009278345,0.05458708,0.012783335,0.011794065,-0.11536123,-0.104531884,-0.090100214,-0.10369957,0.010201039,0.033493865,-0.040967897,-0.050817754,0.0577815,0.029239006,-0.09080737,0.0806101,-0.048647705,-0.0197865,-2.3317306e-34,0.023570487,-0.07073385,0.09456207,0.022325203,-0.053339913,0.06129406,0.0761923,0.014253649,-0.00013483028,-0.049836617,0.011012184,0.078304306,0.016145617,-0.029583389,-0.010088073,0.03929518,0.02817084,-0.025200393,0.011934624,-0.048709203,-0.06422142,0.13160338,-0.00086653384,0.057571284,0.051533118,0.010212052,-0.018924661,0.020003451,0.014143044,0.065233946,-0.037067246,0.0074396813,0.0466488,-0.07321737,-0.024042044,0.008565668,-0.002677855,-0.00069560925,0.0039011247,-0.029626867,0.008877939,0.006813189,-0.053379625,0.024072304,-0.06408702,0.12173901,-0.07386369,0.0052959514,0.07850411,0.038020566,0.00015435537,0.0285692,-0.07647339,0.0013139371,0.01816541,-0.0088927755,0.01570213,-0.028443867,-0.041514266,-0.028439822,-0.061164662,0.009791474,0.034487754,-0.060823828,0.05298239,0.07025336,-0.002711312,0.030797655,-0.026441861,0.046452355,0.08589224,0.016036475,0.02380414,0.022008045,0.002750807,-0.0819242,0.01944539,0.0101649705,-0.022399487,0.021186698,-0.028246135,0.0034094704,-0.03291466,-0.040578213,0.12783027,-0.06468386,-0.0076455246,0.011150867,0.008322791,0.070906386,0.015325577,0.010903455,-0.0016056264,0.038214758,0.06837408,-1.8068151e-08,0.08605618,-0.05367689,0.044418186,-0.03916893,-0.0502243,0.012198128,0.031831555,-0.07744416,0.025400989,-0.07343647,0.006572656,0.05031227,0.0029943069,0.015246615,0.07338816,-0.0486583,-0.022499552,-0.01621718,-0.05588114,-0.09513408,-0.12007184,-0.0063944883,0.037734654,0.021108499,-0.007907547,-0.01101404,0.13661483,-0.0056436444,0.049352575,-0.0038630364,-0.07482341,0.02754483,-0.077910244,0.027576327,0.07112268,0.11533216,-0.05002512,-0.02558611,0.0010455151,0.06869641,-0.023826933,-0.03668644,-0.015587051,0.021998055,0.008110088,0.027498756,-0.03140893,0.033749852,-0.009881307,0.017822916,0.02890573,-0.02996957,-0.019985009,-0.064777374,-0.036367163,0.021407505,-0.010622985,-0.016634421,-0.015497324,-0.048971612,0.040614363,-0.06089967,0.1101577,0.019333985 +1.1.1.194,"Specific for coniferyl alcohol; does not act on cinnamyl alcohol, 4-coumaryl alcohol or sinapyl alcohol.",384,1.0,0.05303437,-0.082965046,-0.008153517,-0.07802498,0.03241605,0.06174098,-0.017583877,-0.009458468,0.026330765,-0.04345946,0.038566165,-0.027001396,-0.12180267,0.13728498,0.00068938744,0.06319588,-0.00982358,-0.027358787,0.02704039,-0.021426715,0.043686524,0.10332348,-0.0028530024,-0.0022445135,-0.0029169268,-0.05109033,-0.023952758,0.015668422,0.04207283,-0.02095734,-0.002333195,0.076014884,-0.041863833,-0.02368382,0.01869332,-0.06639466,-0.105625264,-0.06753983,0.13974966,0.11509143,0.07415905,0.049551126,-0.04215285,0.033146072,-0.06753228,0.026561862,-0.030714264,0.056895155,-0.03828151,0.03392989,-0.031481374,-0.020046506,-0.04488393,0.017461166,0.0504343,-0.03431545,-0.049383413,-0.0028089862,0.012436664,0.075319245,0.03175801,0.03088622,-0.009569177,0.027235338,-0.069448546,0.029280115,0.005082206,0.05279753,0.01798143,-0.053079545,-0.004684674,-0.10260392,0.046368226,0.029880932,-0.008005671,-0.028893383,-0.023929095,-0.014375613,-0.0061934013,-0.036691632,-0.10273367,0.034516186,0.03160576,-0.0072677527,0.10351254,0.0010832476,-0.05463189,-0.010970213,0.0062507405,0.032157235,0.0083359005,-0.02954647,-0.043634895,-0.100240864,0.0037924305,0.04607601,0.013907749,-0.016700858,-0.037989344,0.02186456,-0.038345117,0.038552344,-0.04459506,-0.11200809,-0.07971477,-0.018971786,0.02920146,-0.015096901,-0.049571212,-1.2690721e-05,-0.033865247,-0.025644176,0.09406088,-0.034954388,-0.0099046575,0.09033947,0.048632372,-0.040327337,0.023277253,-0.066957854,-0.03875086,-0.037267774,0.10612546,0.049476586,-0.07097251,0.10037646,0.048890136,6.671507e-34,-0.0153125515,-0.04564261,-0.030831574,0.023319641,0.049786344,-0.044186443,-0.06043883,0.0148781305,-0.056621596,-0.054145366,0.019208573,-0.014719003,-0.0012983164,-0.012990582,0.03460521,0.017623866,0.04403826,-0.022029469,0.016670734,-0.032322362,0.05272363,0.112452015,-0.084086016,0.037266664,-0.08249858,0.003207699,0.028971262,0.06053466,0.01924521,-0.012001543,0.0010419845,0.01206205,0.010637715,-0.024653524,2.0270876e-05,0.060267407,-0.1325063,-0.041311253,-0.06614339,0.0076305843,0.04072858,0.1041421,0.036350302,-0.0055595804,0.006329979,-0.013103954,-0.09068055,0.025861949,-0.06414497,-0.010446807,0.01968329,0.06600783,0.037938196,-0.0151465945,-0.0551668,0.046990696,0.05558647,0.0014226945,0.029692179,-0.033305466,-0.05425124,-0.05876302,-0.049140085,-0.09119091,0.0066166148,0.02997204,-0.04151748,-0.02220143,-0.00530131,-0.02735706,-0.01253418,0.011795828,0.042983513,0.02567668,0.06818191,-0.037340235,-0.020143783,0.013929145,-0.0063570337,0.017255913,-0.053528868,-0.05178322,0.053145453,-0.01838074,0.0031312406,-0.10452633,0.056334913,0.019125072,0.012716294,0.0055206,0.04177069,0.01313089,-0.01712919,0.05705922,0.065975174,-2.1963078e-33,-0.016406905,-0.07977652,0.066247836,-0.03104353,0.0033178772,0.065532066,0.060125433,-0.08907987,0.03951486,-0.07621201,0.123455055,-0.008921663,-0.0756964,-0.013352145,0.007205921,0.039858192,-0.019941358,0.08725905,-0.046991877,0.01833822,0.0011663217,0.06673753,0.004816279,0.07186624,0.030842725,0.03809353,0.029285504,-0.028388012,-0.013633583,0.0057555176,0.017117318,-0.032728426,-0.019651629,-0.03486461,-0.12005554,-0.03392584,-0.023154313,-0.02263253,-0.15480359,-0.025714187,0.08487875,0.03801439,-0.0388125,0.07561965,-0.028262297,0.015766561,-0.101307064,-0.049062084,-0.038156018,0.02335875,0.04615482,0.01185845,0.013362382,-0.008173624,0.05302805,0.048698448,0.003287644,-0.101535186,-0.04394437,0.0143041825,-0.042937055,0.027633967,0.0027900299,-0.043603573,0.080810435,-0.055911146,-0.053014554,0.12710701,0.02875011,-0.06718073,0.05216261,0.066671826,-0.00924562,0.0653195,-0.067896925,-0.104671076,-0.021181922,-0.026291562,-0.035841282,0.024232924,0.0030062327,-0.00038981307,-0.07168903,0.05269037,-0.010565286,-0.045565553,0.027722003,0.059202824,0.0333368,0.064954355,-0.026465723,0.076032035,0.024792945,0.026422448,0.051206343,-2.374159e-08,-0.040755864,0.031555127,0.04196307,0.028161256,-0.07070951,-0.011945556,-0.00553208,-0.043359093,-0.04878475,0.0027392525,-0.029639687,0.08560372,0.006751947,0.009411473,-0.015838621,-0.009661974,-0.033557605,-0.04397421,0.0053711194,-0.031064222,-0.036343537,0.01706334,-0.0017370817,0.078501,-0.077898316,-0.056942653,0.014898161,0.08522705,0.03233862,-0.04145095,-0.02270534,0.05544932,0.008794601,0.008844118,-0.037412684,0.061115783,0.018936157,-0.05192477,-0.07892657,0.06519778,0.020261899,-0.0960942,-0.0034419622,-0.015302115,-0.017562715,-0.019175852,0.026326839,0.015853768,0.020652253,0.062464714,0.06312877,0.09130895,0.025480779,0.00024794228,-0.0681194,-0.05361326,-0.03579342,-0.008383928,0.0141564105,-0.11453691,0.106238745,-0.051955495,0.16925453,0.06947666 +1.1.1.195,"Acts on coniferyl alcohol, sinapyl alcohol, 4-coumaryl alcohol and cinnamyl alcohol (cf. EC 1.1.1.194 coniferyl-alcohol dehydrogenase).",384,1.0,-0.016292825,-0.051148314,-0.04586292,-0.05438665,0.07949766,0.1117559,-0.03332507,-0.008214817,0.019742958,-0.019360913,0.055325072,-0.05995784,-0.15222214,0.097122505,-0.009382729,0.057065632,-0.0669255,-0.024115674,0.019875668,-0.04315521,0.05593978,0.08294334,-0.027564948,-0.00797498,0.029025238,-0.016930446,0.010709118,-0.0064656786,0.0017088337,-0.05963635,0.025703141,0.031617183,0.016569262,-0.026451882,-0.016480388,0.00015145283,-0.049234528,-0.105371535,0.12847091,0.10843475,0.08202164,0.0023351337,-0.028911423,-0.005168235,-0.077899426,0.024940753,-0.01422576,0.09267973,-0.008308828,0.03872684,-0.03396058,-0.029844884,-0.04822665,0.016508033,0.052802164,-0.021658184,-0.03196389,-0.005659346,-0.0077898772,0.059422873,0.020467319,0.009980803,0.0010850397,0.074515015,-0.058836687,-0.009511821,0.058460344,0.03346868,0.015728794,-0.06155776,-0.050035473,-0.096140936,0.012153544,-0.022846537,-0.04499039,-0.017101064,-0.03806246,-0.040549796,-0.008282647,-0.08221389,-0.035154514,0.043398425,0.048274413,0.028561518,0.06298952,-0.004515269,-0.030625282,-0.01031772,0.006287775,0.05716645,0.020945532,-0.05974392,-0.069245055,-0.062901616,-0.00442048,0.096491,0.049831994,-0.037124697,0.01573986,-0.017408602,-0.062409222,0.052106466,-0.0069419765,-0.120458454,-0.09416316,-0.0064412737,-0.026322586,0.03491966,-0.0318142,0.022277405,-0.020713937,-0.011505901,0.05290699,0.0005265715,0.026980693,0.10714498,0.061574724,-0.07485065,-0.018681915,-0.0814554,-0.01283425,-0.029916413,0.112747096,0.09773532,-0.055318404,0.08174777,-0.027673556,9.056891e-34,0.008453981,-0.040293947,-0.04326072,0.03111903,0.03880459,-0.061836455,-0.06670297,0.060376473,-0.09049299,-0.009803965,0.01093624,0.0073455786,0.061784178,-0.008717565,0.00512385,-0.020576492,0.032637753,-0.018388743,0.0086611165,-0.01747373,0.025346424,0.12433264,-0.07767947,0.02305623,-0.062506564,0.050796717,0.020991752,0.038499814,0.017804002,-0.026465248,0.014239204,-0.03944575,-0.009598476,-0.0074389763,0.040741537,0.02527491,-0.10479275,-0.03996065,-0.05965779,0.021659683,0.030030048,0.03746994,-0.011078607,-0.057520457,0.020292109,-0.007020408,-0.10006559,0.05547644,-0.013070698,0.03896749,0.046850808,0.03062489,0.095163815,-0.04998369,-0.10035144,0.06761193,-0.009340493,-0.02634762,0.03795628,0.020206153,-0.06250639,-0.022103902,-0.048675742,-0.075926274,0.02468177,-0.019160952,-0.083376154,-0.05334575,-0.0006087457,0.012273753,-0.04228993,-0.023332572,0.06552884,-0.046269856,0.031898927,0.031952206,-0.048365686,0.02913269,-0.04023099,0.056860846,-0.051918678,-0.015381956,0.05128954,-0.040415626,0.0036222902,-0.050900284,0.0020403985,-0.04335028,0.014418147,0.013556809,0.029842343,-0.02624682,-0.012953437,0.008774663,0.11066451,-3.057617e-33,0.054227494,-0.09397006,0.025953755,-0.05551716,-0.049034458,0.11027024,0.046380527,-0.06237492,0.0038899686,-0.026337055,0.07389919,-0.0057021175,-0.046781555,-0.07765782,0.016865505,0.026170023,-0.002394107,0.08818191,-0.057707038,0.0052565243,0.024317956,0.08929971,0.043692585,0.05887081,0.05673529,0.0376745,0.054314118,-0.023378361,0.021140499,0.03726661,0.013538899,-0.050216883,0.013144276,-0.02250484,-0.054126207,0.004632361,-0.04555189,0.007814843,-0.07740597,-0.015433246,0.06327149,0.03345194,-0.003170326,0.0899311,0.03984852,0.04209335,-0.13128373,-0.027432095,-0.07317489,-0.0070898603,0.039413393,0.033232324,-0.0123272035,-0.01768049,0.0456722,0.05090483,0.02870557,-0.07831911,0.01603892,-0.023224728,-0.06374783,0.028719451,0.02591861,-0.0063281124,0.021481926,-0.06422697,-0.06478932,0.064670496,-0.0031698782,-0.04443147,0.049131833,0.04836357,-0.030652264,0.07874303,-0.0425064,-0.10886255,-0.047518443,-0.02642394,-0.034737334,0.013059848,0.0020021575,-0.0014215374,-0.039174918,0.025358751,-0.03094092,-0.06925538,0.059631165,0.09160905,0.04390522,0.052449733,-0.041778397,0.08802314,-0.037254818,0.06438966,0.04448854,-3.1151643e-08,-0.03694893,-0.0038548622,0.0883607,-0.008539301,-0.027588561,0.00816116,0.037245866,0.0514726,-0.017255804,-0.011243097,-0.0028008802,0.086689234,0.020047432,0.032346215,0.024391841,0.010859529,-0.08060875,-0.03910116,0.0007192351,-0.038855124,-0.028060427,-0.02322924,-0.027285961,0.0844869,-0.04894722,-0.07784879,0.015936498,0.08391562,0.06237842,-0.019112958,-0.036568988,0.054260276,-0.0058950516,-0.038289662,-0.044624988,0.042559735,0.010217222,-0.06751938,-0.070081815,0.038857654,-0.00010643596,-0.08384931,-0.0324537,-0.018287795,0.015096105,0.026916543,0.0051517286,0.016232066,0.014033511,0.043045755,0.044577952,0.06374056,0.01894365,0.039533716,-0.11393862,-0.028440982,-0.031805467,-0.09213161,0.042085025,-0.1011178,0.07701712,0.0062334053,0.18999904,0.06512167 +1.1.1.196,Specific for prostaglandins D [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)].,384,1.0,-0.099118724,0.0048139878,-0.019440996,-0.106612995,0.02082675,0.052906085,-0.07351442,0.10641978,0.0024639268,0.013190989,0.015543066,-0.025292037,-0.07944613,0.006288792,-0.0702767,-0.014044532,-0.018397458,0.023692997,0.022121742,-0.024447864,0.0031946686,0.034284927,0.063066304,-0.0026432124,0.06666642,0.009528972,0.031567026,0.07612665,-0.001737922,0.011308317,0.01201164,-0.04421127,0.002573786,-0.029962214,0.03506381,0.06179739,-0.05406438,-0.022594232,0.011764541,0.06756646,0.052309617,-0.026635453,-0.034261204,-0.019104911,-0.043784685,-0.024658304,-0.06626964,0.09171455,-0.0047962302,0.06586009,0.03831677,-0.022835061,-0.011713687,0.026801184,0.06877988,-0.08544934,-0.004218461,-0.013374556,-0.02767561,-0.006391141,-0.049038123,-0.08137194,0.014554812,0.0088782,0.038992416,-0.0073629133,0.06546376,-0.0369336,-0.04509544,-0.012514344,-0.1154536,0.016171101,0.036203362,0.054292712,-0.03913327,0.078708544,-0.09663935,-0.10181126,-0.014351578,-0.1376152,0.074164376,0.057554737,-0.01097252,0.07002588,0.025304569,-0.0036488208,0.026149942,0.018732488,-0.024633478,0.00041485048,0.054150235,-0.04214467,-0.037610613,0.05652315,-0.086024344,0.033852026,0.03154371,0.016343638,-0.014810794,-0.06647727,-0.0566391,0.04590161,-0.052609626,-0.065004185,-0.020767404,0.0029551843,-0.042748827,0.09328416,-0.03987883,-0.024702363,0.014964135,-0.052467857,0.020522237,0.0046587065,-0.019179339,0.07179791,0.0056001944,-0.01599931,0.0189708,-0.07293611,0.02100634,-0.026641935,0.06463921,0.017576607,-0.03172398,0.026188234,-0.063531235,3.926343e-33,0.11062073,-0.024977868,-0.021256324,0.048148055,-0.016319402,0.04660811,-0.13295692,0.054727342,-0.021600757,-0.050735407,-0.07094444,-0.0037211583,0.041598298,0.0018670076,-0.013713553,0.010082381,0.058119282,-0.056187492,0.004002122,-0.028233755,0.01713199,0.09163456,-0.034418955,0.03712722,0.05165505,0.05935028,-0.042514782,0.09076909,-0.0076341704,-0.0076047895,0.02242309,-0.11733421,-0.09575907,0.0631803,0.045840047,0.035603058,-0.03880941,-0.020642081,0.025505293,0.038862802,-0.05302166,0.008965632,-0.002913329,-0.077308156,0.031171655,-0.037514977,0.00084231584,0.04100827,0.04813166,0.02764379,0.027310457,0.029040752,0.07727297,-0.12177018,-0.07238377,0.04310342,-0.06342611,0.04671363,-0.0019626867,0.11612691,-0.0035133353,0.08901418,-0.002124856,0.0019900764,-0.044332873,-0.014407692,-0.10492997,-0.05721169,-0.0017492225,0.038834352,0.017680736,0.030058788,0.1669719,0.01645024,0.05460271,0.012010594,0.040896,0.04862939,-0.04817089,0.038016424,-0.06953006,0.025066115,-0.066035464,0.03136583,-0.05868559,0.052113645,0.004173145,-0.042277258,0.002420824,0.03576668,-0.027364364,-0.046240102,-0.057346635,-0.053677868,0.03530063,-5.3480504e-33,0.020274442,0.03422797,0.036769245,-0.09631399,-0.025961515,0.13453789,0.05653934,-0.03140438,0.009174971,-0.042290173,0.110092536,0.06387329,-0.048024084,-0.06330381,-0.004069121,-0.0069172885,-0.14955983,0.002571925,-0.051079188,0.029734327,0.04564476,0.06418985,-0.008869413,0.049750052,0.10132628,-0.0052940254,0.037214536,0.04052846,-0.004990075,0.04874947,-0.007531405,0.053955827,-0.10928483,0.04596248,-0.04597871,0.011397142,-0.04663573,-0.02370489,-0.046960022,-0.001143113,-0.032768197,0.012973294,-0.008795536,0.05019398,0.08861627,0.05927182,-0.019942984,-0.033691324,0.018475337,-0.0420451,-0.029867606,0.08290025,-0.015734104,0.0024851754,0.051683012,0.013450358,0.036912434,0.040330004,0.057538737,0.0034903903,-0.004862777,-0.013667389,0.06296956,0.022246059,-0.021023076,-0.0130609805,-0.0047716075,-0.04696218,0.08097611,-0.0016384275,0.07151624,-0.034400232,-0.0017091063,-0.030971179,-0.030107222,-0.03921312,-0.045282815,0.0062340335,-0.04864723,0.033654034,0.042322055,0.035541605,-0.027975954,0.05038963,-0.020788632,0.056825656,0.012454716,0.03349059,-0.05710008,0.027178803,-0.037873074,0.07489501,-0.107985474,0.026783707,-0.016963206,-3.6832688e-08,0.06344438,-0.03617644,0.04528334,-0.08267689,0.045448277,-0.0022287497,-0.02687701,0.008896706,0.006053439,0.018812168,0.0035874886,0.11794968,-0.011973329,-0.004967758,-0.01963182,-0.032209244,-0.02344435,0.002971262,-0.024558205,0.03271446,-0.04544178,0.014871278,-0.118206814,0.007644599,-0.030989014,-0.04806644,0.04303277,-0.08671286,0.058299657,-0.023946516,0.0541448,0.0045400797,0.031979818,-0.08190069,0.05539266,0.053117804,-0.059594918,0.05098665,-0.04329315,0.053046625,-0.015527633,-0.15511757,0.022071417,0.033683024,0.018152416,0.027759997,0.04316922,0.021604057,-0.03929972,0.0078068804,0.000504041,-0.059002314,0.011166916,-0.08360889,-0.09746586,0.07610954,-0.043836746,-0.082435384,-0.033355273,-0.07315224,0.0024710544,-0.028939286,0.109681904,0.013841235 +1.1.1.197,"Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.",384,1.0,-0.109393,-0.041528948,-0.05392472,-0.111060776,0.072335586,0.027679974,-0.041087855,0.06779631,0.006394098,0.0054772296,-0.031238211,-0.040143415,-0.07127991,0.009494891,-0.016951282,-0.007617209,-0.042955395,-0.03366087,-0.014800369,-0.05309313,0.0018634583,-0.024138574,0.028626168,-0.022166183,0.061040517,-0.0012534977,0.028787667,0.063978866,-0.038260825,-0.06729719,0.025006024,-0.09080044,-0.063977346,0.023132002,0.009895632,0.097118825,-0.046766322,-0.02632891,-0.040176235,-0.007357876,0.046061065,-0.022943338,-0.066765174,-0.03587415,-0.051004995,-0.014223764,-0.02405119,0.10691831,-0.013219934,0.040045798,-0.0036221277,-0.040692836,-0.0047205333,0.023178166,0.064407304,-0.041638605,0.005044512,0.023240922,-0.024976067,-0.006448373,-0.04798551,-0.09944394,0.029721921,0.011710554,0.021535698,-0.009014982,0.04302,-0.07068645,-0.08344103,-0.016330488,-0.03842077,0.031114869,0.014971962,0.013533136,0.008017973,0.04345929,-0.11075038,-0.050877,-0.04743367,-0.08072661,0.050836574,0.0024260092,0.02058286,0.052118808,0.035361152,-0.04343677,-0.031469326,-0.018281033,-0.05771059,0.04055317,0.03664758,-0.0014092076,0.02711571,0.08612557,-0.040829923,0.029672833,-0.009333679,0.043820955,-0.011657232,-0.052471586,-0.105670124,0.09098175,-0.062274855,-0.049953144,-0.037398417,0.010444629,-0.029669913,0.094983645,-0.051252488,-0.031161923,0.07232738,-0.04880251,0.04843844,0.059783794,-0.03112512,0.06305721,0.004266584,-0.034856107,-0.08148716,-0.07686094,0.03242018,-0.015981099,0.05771425,0.034911543,-0.034696057,0.002957113,-0.06770623,5.5676405e-33,0.076706514,-0.034554135,-0.029039435,0.010636283,-0.006601216,0.07424325,-0.12745719,0.061622523,-0.006830648,-0.03761836,-0.030978862,-0.017382633,0.061857082,0.009658288,-0.02836866,-0.019516246,0.10601461,-0.0592026,-0.00500274,-0.032022256,0.07008401,0.07972159,-0.053068765,-0.021947812,-0.009573406,0.08369711,-0.027312772,0.09496606,0.00834608,-0.009164596,-0.011608968,-0.13909245,-0.06319163,0.121955045,0.0833638,0.01976724,-0.04183468,-0.008386679,0.0031840329,0.028035989,-0.013028257,0.018669998,-0.032459233,-0.09032259,0.038837414,-0.062192414,0.016515164,0.05047734,0.07746882,0.04676201,0.04794014,0.023601396,0.102937736,-0.079968296,-0.046795197,0.01847504,-0.026447522,0.02180877,0.01534147,0.11751998,0.022920612,0.10107973,-0.014978008,0.0026658543,-0.023583733,0.045515653,-0.07306376,-0.049620237,-0.029282903,0.06636257,0.046857443,0.04759636,0.17982906,0.016252872,0.06465195,-0.003287289,0.031223793,0.03187715,-0.012673279,0.022161117,-0.0370462,0.012770271,-0.05784666,0.0114066675,-0.0818887,0.028017536,-0.0433996,-0.07789022,0.009812094,0.071950026,0.04107801,-0.038440373,-0.063943855,-0.040770095,0.09144914,-7.028276e-33,0.016398536,-0.012509463,0.06534687,-0.08650781,0.0028003855,0.13171619,0.08540784,-0.034289315,0.009220734,0.011202106,0.09903134,0.019678919,-0.06333446,-0.012371912,0.0033571469,-0.03250616,-0.06721996,0.016524825,-0.02360881,-0.011984302,0.039154273,0.09994373,-0.005214075,0.056831613,0.058395512,0.03329373,0.031007817,0.07041002,-0.006057486,0.03472873,-0.03878537,0.07862027,-0.10959843,-0.012941229,-0.03707016,0.032384675,-0.087329015,-0.034061193,-0.05087323,-0.030090299,-0.009507602,0.008871267,-0.0009913823,0.0069185086,0.10065662,0.04928053,-0.027955087,0.031505838,-0.03751907,-0.057350423,-0.032443915,0.10067758,-0.03114656,-0.0023328238,0.04131023,0.022161538,0.067990504,0.021347245,0.043907214,0.012399831,0.024374563,-0.041362777,0.017904079,0.017738918,0.005213745,-0.049015436,0.04057472,-0.013904952,0.123821,0.07069433,0.0716608,-0.0624371,-0.0026852274,-0.0027643603,-0.05502277,-0.010481678,-0.07292695,0.0067422786,-0.0079618925,-0.011054253,0.030507034,0.012402027,0.0044667725,0.011713844,0.027212668,0.013103867,-0.031007461,0.026740061,-0.0715407,0.03140763,-0.019317532,0.06932847,-0.063757345,0.019321324,-0.002066991,-4.353697e-08,0.060182847,-0.013477302,0.08634384,-0.029422281,0.029813237,-0.0898953,0.0016105877,-0.0025571228,-0.008754709,-0.015972018,-0.06781868,0.094125405,0.02816402,-0.06481237,0.016427344,0.007204479,-0.0173928,-0.02738285,-0.020181637,0.038141947,-0.03936513,-0.029023863,-0.16361071,0.020023188,-0.07705062,-0.0242188,0.008118719,-0.029241178,0.07294099,-0.051666982,0.07190573,0.0015763486,0.03508256,-0.08027187,-0.008709251,-0.013674434,-0.035092656,0.055569503,-0.048789646,-0.02495289,-0.03060747,-0.07753471,0.03299845,0.048220005,-0.014327403,0.049751613,0.0460152,-0.033343438,-0.005494678,-0.0006236643,0.009186763,-0.043806206,0.0030454989,-0.042788096,-0.08892981,0.043918222,-0.031459842,-0.04814556,-0.006406954,-0.0073339953,0.052215084,-0.021568801,0.08761513,-0.0071618427 +1.1.1.198,"NADP+ can also act, but more slowly.",384,1.0,-0.053992137,-0.105439894,-0.01864176,-0.009106063,-0.00077834836,0.07565395,-0.046764635,0.046248246,0.04366526,0.027993914,0.02309399,0.048356857,-0.07073112,0.1173433,0.041363623,0.025087457,0.05568001,0.027636908,0.03745261,0.03902409,0.03295715,-0.02311679,0.07520235,-0.06870408,0.017507976,0.034424387,-0.08392694,0.023662042,0.063176595,-0.10595124,-0.014502133,0.045139324,-0.070539564,-0.048174646,-0.08208639,0.0874997,-0.07537328,-0.005541702,-0.016426783,-0.053086396,0.04850765,-0.030446313,-0.07350972,0.0166074,0.017861439,-0.066710025,-0.012710075,0.016198013,0.016167657,-0.028261373,-0.0814141,-0.03518136,0.019391524,-0.0034326012,0.058892876,-0.027389739,-0.05195994,0.011537591,0.00408795,-0.08087138,-0.041447602,-0.029898925,0.021182215,0.032484274,0.081184186,0.027791243,0.074965775,-0.006835019,-0.015634503,0.04877972,-0.07729771,0.03531266,-0.0033733028,0.03271925,0.010254013,-0.006711916,-0.080773376,-0.059176866,0.07412146,0.03189693,-0.0024026576,0.04822874,-0.10315478,0.009910858,0.017894927,0.04539013,-0.013408386,-0.028071608,-0.089250706,0.009139025,-0.015985956,0.0026588156,-0.04299734,0.06290631,-0.08498832,-0.021036517,-0.0050106235,0.008658482,-0.0758302,-0.01591862,0.011233859,0.10968947,-0.03466546,-0.012557304,-0.019723995,-0.033191446,0.021377176,0.013078935,-0.081317075,0.059545316,-0.042232204,-0.040859196,0.029290576,-0.00085322995,-0.022503478,0.116491474,-0.06293265,0.021480806,-0.08733713,-0.041264646,0.021750385,-0.032950595,-0.023460526,-0.012537466,0.011492291,0.018175274,-0.03375242,-1.7590843e-33,0.0836015,-0.037433635,-0.012330401,0.021884223,0.02740073,0.018148921,-0.04927342,0.036972865,-0.017758014,-0.031334836,-0.052974854,-0.14371257,0.04001801,0.0114379125,0.020071112,-0.019050442,-0.03733201,-0.030411871,-0.07507141,-0.0474787,0.064534284,0.08514022,-0.0029337197,-8.957065e-05,0.023892116,0.025630936,-0.03506582,0.07463895,-0.0036398156,-0.004954917,0.04571425,-0.051805433,-0.16549711,0.0525725,0.040307898,0.05495044,-0.0328677,-0.08826097,0.040419042,0.01588887,-0.12732148,0.075193375,-0.064871885,-0.009743349,-0.004579038,-0.08332702,-0.012508172,0.06040807,-0.05337187,0.048986796,0.08520252,0.015224105,0.0740225,-0.038111616,0.02290255,0.08306533,0.04616853,0.00033445065,-0.07515445,0.13910742,0.063858666,-0.023714038,-0.0060284147,0.058438964,-0.08488984,0.044318177,-0.11108663,-0.044450477,0.05226782,0.00520261,0.060969032,0.034844365,0.04748394,-0.04127276,0.056402165,-0.09519969,0.059267137,-0.064809054,0.014920457,0.014001876,-0.0013329142,-0.08854652,-0.04192058,-0.0042114253,-0.009783584,0.006222436,0.04928761,-0.07130364,-0.01761477,0.03678526,0.005006887,-0.018064722,-0.0008303699,-0.034138255,0.026976852,2.9520862e-34,0.059258033,-0.03359154,0.051645085,0.018049955,0.021074966,0.083535984,0.019906064,-0.0272716,0.0038431482,-0.054446004,0.045245834,0.051824052,-0.014569614,0.0016204698,0.027245203,0.014557378,0.029319275,-0.0012884202,0.023632634,0.01763384,0.008779683,0.13589373,0.040215086,0.015625928,0.0027035954,-0.018376887,-0.028435752,0.02657386,0.006481477,0.026264895,0.0024986418,0.028592627,-0.16071601,-0.04727065,0.030168535,0.07267919,-0.046570178,0.014519584,-0.06642263,-0.021398043,0.04264731,0.0025308675,-0.007047142,0.057877537,0.03988574,0.022922484,-0.00040331858,-0.045100648,-0.008009211,0.053470116,0.017210824,0.045836557,-0.070839584,0.02565326,0.06497449,0.0084097795,-0.00012199629,-0.025803166,0.009786255,-0.01591895,-0.0017260272,-0.033367712,-0.023472035,-0.035425127,0.13653968,0.041765783,-0.0042363578,-0.014336332,0.1269283,-0.053198427,0.07409816,0.012885679,-0.020037845,0.03445568,-0.022039179,-0.061800428,-0.060088284,-0.017750368,-0.012565085,-0.11004151,-0.045088325,0.018729802,-0.013728986,-0.08846276,-0.06747314,0.067244776,-0.015532202,-0.009637356,-0.008447149,0.053709976,0.038417276,0.08085371,0.06146499,0.01830158,-0.02769033,-1.8711123e-08,0.019091269,-0.004823615,0.044008717,-0.04106396,0.020009272,0.047054313,-0.0023039451,-0.032945074,0.00020943786,0.042502064,0.08327548,0.12807308,0.1116748,-0.0020704975,0.086939156,-0.02141404,-0.04125895,-0.0051088147,-0.047821596,-0.010107712,-0.060117234,0.017608061,-0.04379593,0.047316276,-0.041492738,-0.019679066,-0.020873459,-0.0038509618,0.071257085,-0.09114454,0.03390865,-0.00073187135,0.043669973,-0.0020362183,-0.02110987,0.0774485,0.03745717,0.054519728,-0.03682305,0.097156644,-0.071463384,-0.0813822,-0.0016031318,0.036002763,-0.049728405,-0.007067964,0.030291414,-0.11113641,0.005308863,-0.05265698,0.096433885,0.022971477,-0.010667136,-0.041644767,-0.0302403,0.075865045,-0.030773629,-0.023823692,0.030419001,0.0041237157,0.021255625,-0.06390395,0.0204287,0.026062455 +1.1.1.200,"In the reverse reaction, acts also on D-galactose 6-phosphate and, more slowly, on D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate.",384,1.0,-0.05460215,-0.08003054,0.018601168,-0.0047772424,-0.0015730162,-0.008187908,-0.008935928,-0.005463413,0.032022633,0.13720083,0.013414467,0.06551262,-0.1245658,-0.019720336,-0.0453082,0.007983021,-0.017416088,0.06467573,-0.02235198,0.071682684,0.10928443,-0.03290912,0.022812769,-0.025171135,0.10885264,-0.01813116,0.039306298,0.007272627,-0.01186523,-0.0970559,-0.026298013,0.0032530432,0.012292488,-0.012454751,-0.046042714,0.12572111,0.021240063,-0.01613581,0.032840256,-0.05072515,0.016952904,-0.050243404,0.02804312,-0.035740294,-0.010605111,-0.035247356,-0.1517684,0.06858346,0.056732256,-0.0051257615,-0.0075468444,-0.040631775,-0.11243086,-0.005305899,0.04854467,0.071852855,-0.031777535,0.014900147,0.018422984,-0.020321188,0.021949623,-0.0066280914,-0.0118401535,0.05660491,0.085584976,-0.091317415,0.054717638,-0.04557902,-0.011762157,-0.017184751,-0.021566195,-0.02394635,-0.0017106091,-0.10110238,0.0151385665,-0.01765395,-0.0854798,-0.0538852,-0.016791375,-0.026143163,0.06802656,-0.0073492853,0.06503803,0.060617596,-0.029943803,-0.057599604,0.00225005,0.016054641,0.02991801,-0.002648487,0.0032967932,-0.0030306953,0.013583109,-0.00843166,-0.040942203,-0.0063488926,-0.005965051,0.013339184,0.08743523,-0.031668447,0.011547997,0.054389413,-0.048479874,-0.06943847,0.019071044,0.04372956,-0.049858928,0.07200831,-0.016298875,0.022988418,-5.529483e-06,0.032114327,0.07029164,0.08510357,-0.08792206,0.0903554,0.0023645335,-0.0487352,-0.045025647,-0.06967526,0.013957973,0.009615996,0.00082254614,0.005497551,-0.02927928,0.094242655,0.0029389288,-2.5293915e-33,0.046379745,-0.0053617624,0.06769161,-0.039095942,0.022742417,0.03465051,-0.06254049,-0.041034017,-0.0425027,0.022643806,-0.070680596,-0.045086302,0.059770647,0.03989782,-0.061447434,-0.0030493475,0.014267469,0.034340978,0.02911613,-0.057900265,0.02631849,0.09138478,-0.0955087,-0.0412823,0.04335683,0.029388547,-0.022360304,0.062363807,-0.009612907,-0.01822599,0.04487753,-0.04371847,-0.017901292,0.024613695,0.06559232,0.018938215,-0.061315823,-0.0075918823,0.012162976,-0.046694927,0.028278682,0.018396217,-0.10159429,-0.03483122,0.00056050834,-0.05391252,0.033104073,0.015450814,0.045329522,0.07936854,0.066514745,-0.055379532,0.0046755546,0.008669326,-0.011049652,0.051128495,-0.0074117617,0.001740599,0.055232227,0.091232866,0.013802902,0.024958218,-0.030092744,0.039184093,0.014997578,-0.0035593978,-0.03686187,-0.019752106,-0.06281356,0.027227229,-0.0615286,-0.05493475,0.04323834,-0.048658248,0.014162615,-0.020251345,0.011554662,-0.0038159906,-0.016511137,-0.031557698,0.04597058,0.01585259,-0.047239516,-0.06559661,-0.048670985,0.028929744,-0.08420135,-0.13276,-0.037884187,0.077034056,0.05394463,-0.05603159,-0.108203016,0.014751513,0.04011557,-3.3574456e-34,0.046620663,-0.06202443,0.042700853,0.026912896,-0.046163663,0.014356256,0.105771214,-0.032227192,0.08390687,-0.037734635,0.048116054,0.011248935,-0.039040472,-0.03378078,0.00030638915,0.07296887,0.050520517,0.0988939,-0.009376542,-0.008428383,-0.0061998945,0.13717741,-0.010440917,0.06428715,0.051212654,-0.02101403,0.068134576,0.015370425,0.04228778,0.003983642,0.0624103,-0.039489016,-0.016151669,0.019066246,-0.036186617,0.013924722,-0.073947996,0.0077726846,-0.028514849,0.008375679,-0.007053078,0.014525728,0.07845464,0.034403656,0.076253295,-0.007900491,-0.04656371,-0.00013080362,-0.017275795,-0.028161788,0.014766528,-0.04524984,-0.01661622,0.06559412,0.07904792,0.021367628,0.06504099,-0.04566115,-0.0012965063,0.031595707,0.0052677942,-0.029499417,0.09844556,-0.11206791,0.05079562,0.07513826,-0.048077438,0.020240111,0.07062607,-0.0192448,0.045271955,0.033229265,-0.045597844,-0.03622041,-0.012433886,-0.062150214,-0.1242869,-0.022724887,-0.000915815,-0.00990762,-0.039375074,0.07049722,0.0040352144,-0.02144268,-0.08647188,-0.07009577,0.006682798,0.090938635,-0.033062357,0.078166135,-0.07964235,-0.029277759,0.043411102,0.020278169,0.11119859,-2.86889e-08,0.06801949,-0.07956628,0.10817839,-0.028742777,0.0017451171,0.014114962,0.040784884,0.10913318,-0.019980201,-0.06640111,-0.024155252,0.15032583,0.07080432,-0.01064742,1.59431e-05,-0.0013893241,-0.048005555,-0.038498458,-0.06512678,-0.03257037,-0.03852811,-0.03858183,-0.07293251,0.03929707,-0.008141591,-0.031870857,0.07104082,0.025352525,-0.018049605,-0.072540306,0.033214625,0.015393434,-0.06402589,-0.033981055,-0.07546742,0.021319816,-0.0009958099,-0.030777413,0.036908764,0.025946144,-0.012013246,-0.06143812,-0.019733403,0.039935615,-0.10908468,0.056407556,-0.023350775,-0.00046234604,-0.057554886,0.06384616,0.039361823,-0.046007045,-0.11857281,-0.048435904,-0.054589167,0.0205401,-0.020873284,-0.027932609,0.0308831,-0.0016443847,0.036196247,0.0059047183,0.12725076,-0.041831106 +1.1.1.201,Catalyses the oxidation of the 7beta-hydroxy group of bile acids such as ursodeoxycholate.,384,1.0,0.021121474,-0.094586305,-0.03575047,0.041312754,0.0015732702,0.057695758,-0.008379982,0.0128116,0.009713767,0.012084913,-0.041224223,0.013030012,-0.067261055,-0.030278713,-0.076041244,0.020002889,-0.073418565,0.012080907,-0.010715162,-0.026455453,0.062152993,-0.0541126,0.04565554,0.018126978,0.053957988,0.059774153,0.14858408,0.0111243855,-0.04138338,-0.11195174,-0.017906714,-0.030824544,0.08869954,-0.059949312,-0.06125172,0.045225,-0.0033728431,-0.040580682,-0.023314908,0.019979885,-0.0057285335,0.0077083334,-0.017982837,-0.040638637,-0.067384675,-0.05380438,0.016816128,0.03004783,0.043660786,0.019487951,-0.042002123,-0.017850388,-0.051946327,0.0019229113,0.051612917,0.032381605,-0.05497528,-0.07237329,0.009893378,-0.008135726,0.027246742,-0.0020910397,0.062242985,-0.023686077,-0.061426803,-0.046434633,0.0348,-0.02581519,0.018518118,-0.11292905,-0.06860398,-0.031580765,-0.0231309,-0.0042842366,-0.03635239,0.04928195,-0.034013785,-0.07931265,0.008271522,-0.041258745,-0.0108964825,-0.017549174,0.07720595,0.14162923,0.11101725,-0.059912328,0.04547959,0.029166367,-0.013001555,0.017692093,0.017006682,0.029844936,-0.0010748476,-0.05887665,0.03345924,-0.011857283,0.04566533,0.04210969,-0.0012179433,0.00060109125,0.035486333,0.0776635,-0.04866046,-0.124246664,0.00084195717,0.046982717,0.0033142145,0.11411757,0.054922536,-0.07702242,0.018114774,0.018145865,0.06834294,-0.038816053,-0.1742322,0.11136184,-0.008816731,-0.086271115,-0.09003858,0.07420331,-0.0128572285,0.05577018,0.026845131,0.04729723,-0.10473163,-0.009978079,0.037454884,-4.578249e-34,0.055229686,0.042478196,-0.03543269,-0.042117197,-0.007953815,-0.026712323,-0.010607461,0.027577292,0.0713508,-0.05559521,0.0008879176,0.02156804,0.019347498,-0.04962918,-0.014988658,0.022861434,-0.015082345,0.0013410262,0.08052903,-0.027099859,-0.006254057,0.020618027,-0.04172441,-0.04065915,-0.015080355,0.0397367,-0.021919407,0.036788616,-0.00074044114,0.017247196,0.0042416,-0.0088625485,-0.013428649,0.042636763,0.0017657855,-0.004409957,-0.047220033,0.000552441,0.006641419,0.091009416,0.06090105,-0.027764617,0.006500172,-0.040710207,0.022660332,-0.012260936,-0.058342263,0.09078752,0.07550809,0.114197545,0.039356817,-0.03405795,0.03374695,0.01815637,-0.0116016455,-0.07741546,-0.027124306,-0.02777859,0.015216676,0.024828197,0.032110162,0.097594045,-0.059760887,0.0014755672,-0.009455265,-0.00468068,-0.024527455,0.05590831,-0.0762016,-0.03408414,-0.05552362,0.03246378,0.07221169,-0.013432754,-0.07167429,0.034965098,-0.027053557,-0.0126465475,0.033247042,-9.848499e-05,0.004842926,0.015516844,-0.035070878,-0.09292613,-0.036924955,0.06974403,-0.03692821,-0.06543737,-0.08744824,-0.033898897,-0.06539718,-0.030227667,-0.060048368,-0.028640946,0.024780115,-2.6581391e-33,0.07379036,-0.08549302,0.029552296,-0.06598143,-0.0045804037,-0.012351181,0.05414045,-0.026368992,0.016797666,0.012332946,0.013919987,-0.009666056,0.07458916,-0.060285702,0.03150502,0.037295055,0.043746583,0.058572337,-0.029597912,-0.054996554,-0.0054587214,0.1025468,-0.03133296,0.13396922,0.028666934,0.028843066,0.017476888,-0.074794464,0.12989354,0.15122929,0.043919805,-0.034941923,-0.038324565,0.044369522,-0.04135377,0.060360856,-0.08377317,-0.008266255,0.012746479,0.010733295,-0.0077475864,-0.046237297,0.04540956,-0.008168563,0.040849067,0.03420094,-0.051626354,0.0007304094,0.0018238204,-0.078427814,0.0996715,0.017105998,-0.048682522,0.011088327,-0.037927203,0.10814742,-0.06829917,-0.0508159,0.00059044466,-0.079791576,-0.015014142,0.037592012,0.06473728,-0.05095188,-0.098728515,0.038372707,-0.04605981,-0.033878837,-0.036507614,-0.008248437,0.017607797,-0.03225863,0.0062898765,0.055676162,0.04483282,-0.022808274,-0.02178752,0.0078117913,-0.043554697,-0.04923609,0.020570332,0.009553355,-0.0010599156,-0.086302884,0.032098148,-0.04880676,-0.045583308,0.0799476,0.06149425,0.002894366,0.005119777,0.010287431,-0.052594766,-0.025390776,0.042556066,-2.3349076e-08,0.07421229,-0.085918926,0.05459937,0.071762115,-0.0308825,0.049505554,-0.0056684045,0.010307585,0.035565127,-0.050659433,0.017109796,0.116166964,-0.0006649265,-0.02008633,0.017321402,0.03896427,-0.05871833,0.011116407,0.0072899424,-0.018540125,-0.08098508,-0.033843074,0.0060111494,0.018329525,-0.00870706,-0.06440961,0.0138132,-0.09770542,-0.08195773,-0.041268427,0.102404885,0.036838535,-0.06460056,0.005767401,0.0024572234,0.05055853,0.09062397,0.0059204698,0.017244665,-0.00066143606,-0.0643311,-0.046549994,-0.097581044,0.022055592,-0.016147437,-0.024355022,-0.039511688,0.08200316,-0.002689471,0.04719813,0.00031302928,0.0016461341,-0.012781938,-0.02745208,-0.0030819993,0.020909416,0.018924825,-0.049448743,-0.03433427,-0.046642046,0.02823091,0.026680049,0.17874695,-0.05585175 +1.1.1.203,"Requires Mg2+. The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate. The enzyme can only accept the beta anomeric form of the substrate [4]. The 1,5-lactone product is rather stable at cytosolic pH and does not hydrolyse spontaneously at a substantial rate.",384,1.0,-0.042240094,-0.15944418,0.014580355,0.04588853,0.05153307,-0.011797298,-0.02120934,0.052190676,-0.022479774,-0.001183309,-0.019358208,0.038565427,0.019215185,-0.01147771,-0.06987761,0.026425797,-0.024793355,0.046384472,-0.014428068,0.03970778,0.12853077,-0.015745534,-0.008794124,-0.022713114,0.061726958,-0.01835924,0.047262315,-0.0688278,-0.037202176,-0.04564812,0.002545973,-0.023012685,0.09102015,-0.024862863,-0.01016661,0.11195521,-0.016215684,-0.059985317,0.025918206,-0.059685428,0.020825285,-0.014883812,0.06525332,-0.006982999,0.042131577,-0.02773136,0.06710034,-0.03498702,0.011696929,0.027667683,-0.059545584,-0.053831547,-0.032307684,-0.018432386,0.03702429,0.055298652,-0.06851793,-0.083063304,0.002612065,0.026146904,0.044623293,0.025262652,-0.05675402,-0.01832948,0.013586091,-0.0120581845,0.032148216,-0.12762347,-0.02141104,0.015018317,-0.017631255,-0.061119452,-0.026457708,-0.0468524,-0.0076766023,0.049759388,-0.007986636,-0.0871912,0.08581693,0.02366511,0.022989523,-0.024117732,0.067294896,0.050098427,0.032817774,-0.042481467,0.12620723,0.02966534,0.011627528,0.046988145,0.024785822,0.06950354,-0.007963114,0.008000497,-0.06553083,0.005633123,0.032108646,-0.05317709,0.02669346,-0.001817406,-0.011534031,0.04379331,0.06369212,-0.012314197,-0.050357707,0.02916299,-0.023635656,0.066459395,0.052231096,0.039548483,0.024919089,0.006046867,-0.02752172,0.027911492,-0.027759662,0.067993596,0.010742781,-0.09476787,-0.07995253,-0.013313098,-0.015558271,0.020441096,0.027708972,0.030077197,-0.055571895,-0.0017334579,-0.039575566,4.1675257e-33,0.014171735,4.8885402e-05,0.027459772,-0.05986184,0.0003492761,0.051270504,-0.12312036,-0.034344032,0.043893736,-0.008456769,-0.04832847,-0.031062717,-0.0042337165,0.025732616,0.00746607,0.018269787,-0.011312212,-0.046968363,0.10552043,-0.004279482,-0.04095167,0.021940159,-0.020566598,-0.009575668,0.06722163,0.032373942,0.07568099,-0.021229718,0.08063963,0.035105184,0.03082386,-0.116548784,-0.097389884,0.01453538,0.020992428,0.03507247,-0.062321734,-0.011018661,-0.007781964,0.03699651,-0.024577603,-0.0033242684,-0.03249908,0.03474049,0.056881927,-0.076672986,0.011179085,0.081908174,-0.001573371,0.07678933,0.025953984,-0.038786825,-0.006844779,0.07745576,-0.0253721,0.045675933,-0.066997,0.076077655,0.055369437,0.015734114,0.049078714,0.028905597,0.02374539,0.057414018,0.00066393707,0.07399832,-0.06458471,-0.036826476,0.008317733,0.027927442,0.0027515143,-0.03985798,0.053398605,0.029498897,-0.07295311,-0.013558055,-0.00481549,-0.0023419976,0.032495566,0.03819228,-0.007910681,-0.024411555,-0.0055144844,0.022948906,-0.053120494,0.04288467,-0.006861378,-0.021944474,0.002021546,-0.027052792,0.08411397,-0.043289877,-0.007888477,0.031785324,-0.023218444,-3.3110825e-33,0.09164773,-0.09485421,0.10193672,-0.01809622,-0.015400065,-0.034076225,0.03446039,-0.061230253,0.027310465,-0.041198485,0.038681973,0.014534415,-0.0061464184,-0.08792099,0.01361182,-0.049933046,0.00071918766,0.08550279,-0.06402356,0.0052123526,0.042879883,0.1363939,-0.010286428,0.00961309,0.027284192,0.030329468,-0.058384676,0.021953912,0.051588334,0.089779936,0.025785957,0.102821656,-0.027677633,-0.109864175,-0.047423977,0.044847142,-0.02757692,-0.010185247,-0.015442439,0.08130802,0.016188398,0.08108307,0.045108225,0.027623236,0.090691626,0.07987729,-0.019630022,0.037053492,0.07772738,-0.07066697,0.030399883,-0.067903005,-0.044148188,-0.033940583,0.033794742,0.05012831,0.018690525,0.01613696,-0.0111386115,-0.05852606,-0.041820686,-0.04181371,0.12966233,-0.09433101,0.025523327,0.060288146,0.035592858,0.08363855,-0.005588906,0.046853825,0.05640007,0.054585934,0.016653858,0.07253168,0.02864589,0.09750368,-0.09827801,-0.017540423,-0.018466061,-0.06860392,0.055057984,0.080274716,-0.044592872,-0.012254831,-0.012881217,-0.10810848,0.0027893016,0.09413312,0.0056682355,-0.018188126,-0.09782521,-0.047899004,-0.06549786,0.059721064,0.04452583,-3.681281e-08,0.008434325,-0.010567077,0.0019976464,-0.09899136,-0.0006173836,0.052838378,-0.0067979507,-0.028717505,0.11409199,-0.09224234,-0.054321304,0.09193903,-0.05958108,0.01546667,-0.059701055,0.0069560735,-0.029041111,-0.040740155,-0.04675082,-0.051631533,-0.07301514,-0.042386208,-0.093071625,0.04044722,-0.04901962,-0.08412188,0.005062486,0.05752599,-0.103192866,-0.05670442,0.040080722,0.0778935,0.0006301012,-0.021783793,-0.08587499,0.035161484,0.001689486,-0.0055256933,-0.02336348,-0.008836155,-0.029079974,-0.03630417,0.0005162975,-0.016407428,-0.06698608,-0.021107476,-0.0092494795,0.010042155,-0.038532715,0.030666605,0.020324651,-0.02611454,-0.11733917,-0.027904369,-0.03318046,-0.00018661238,0.034212656,-0.05582762,-0.033011567,-0.08319701,-0.0040093116,-0.062817045,0.13031632,-0.07737517 +1.1.1.205,The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.,384,1.0,-0.06339435,-0.06206423,0.0017429808,0.008661476,0.055370368,0.019834738,-0.0017971969,0.027334606,0.041572623,-0.05215496,0.030812372,-0.03790292,-0.051197108,0.063131325,-0.048068658,0.0039185197,-0.0707885,-0.014273991,0.004916738,-0.031419598,0.065024875,-0.032988094,0.022995777,0.029015735,0.020114738,0.033688698,0.12342048,-0.023909718,0.01759783,-0.08043474,-0.039666332,0.012317861,0.0010226207,-0.074863605,-0.026394844,0.13559386,0.005227386,-0.075692184,-0.013155484,-0.015126972,0.10956814,-0.014073056,-0.025764167,-0.028349873,-0.028210478,-0.03478502,0.055192973,0.05999568,0.0217268,0.08788795,-0.0015257938,-0.10827098,-0.045253765,-0.0010573763,-0.028082982,0.06252468,-0.050486688,-0.013773648,-0.06735727,-0.036645394,0.019192621,0.010200077,-0.038613465,0.07207981,0.057885952,-0.06712088,0.050030336,-0.004581219,-0.0058008293,-0.062107284,-0.07029578,-0.07005155,0.052218623,-0.014120396,0.0180084,-0.04942384,-4.7769783e-05,-0.009591851,0.0852383,-0.031084454,0.03796154,-0.018199164,0.012180556,0.12755115,0.035617165,-0.0017021453,0.051239364,-0.030094527,0.05159223,-0.009946268,-0.0071993982,-0.0020842734,-0.11280504,-0.020525232,-0.05987543,0.028358838,0.04007741,0.040668752,0.026352834,0.0008264294,-0.00786307,0.052758854,-0.00010483515,-0.04723656,9.046855e-05,0.0059246584,-0.032885432,0.11493095,0.03759231,0.01278244,-0.06584391,-0.013502231,0.0819838,0.044656914,-0.072244026,0.037340607,-0.024046585,-0.048272837,-0.046710745,-0.044183996,0.016581373,-0.014715378,0.049466144,0.050909497,-0.03208705,0.10130112,-0.070190646,-5.2356827e-33,0.06853659,-0.08216315,-0.023264444,-0.054709695,0.01801496,-0.043598387,-0.059990678,0.04026484,-0.14480451,-0.017109884,-0.06217991,-0.053576678,0.0073556365,0.02306385,-0.01769115,-0.01384457,-0.0076663154,0.008196019,0.029817196,0.053696074,0.024148684,0.045874275,-0.07492302,0.029977843,-0.07592976,-0.0071086534,-0.0018917486,0.06896271,0.066127494,-0.00063007046,-0.014259488,-0.08947519,-0.06554483,0.048921913,0.061681006,0.045999862,-0.026704583,-0.040023424,0.032906886,0.09021207,0.019566149,-0.01706625,0.03646775,-0.07544217,-0.0006216337,-0.021553952,-0.031114224,0.057701223,0.043211315,-0.007538075,0.029599007,-0.011835656,0.061418753,-0.025421575,-0.06667434,0.021918839,-0.050968863,0.02111248,-0.04489642,0.0034377184,-0.06208743,0.056187324,-0.026230792,0.06624076,-0.035637,0.031351097,-0.01649162,0.007746564,0.024439922,0.05298429,-0.08939799,0.0740829,0.04671701,0.055598225,0.016765889,-0.01796467,0.007241746,0.027642995,0.036329627,0.035124205,-0.0034490472,-0.021007191,0.015886249,0.073119536,-0.0714876,-0.019940956,0.0038537693,-0.051277287,0.0026008575,-0.010991883,0.005680029,-0.07002103,-0.018570311,-0.015534494,0.02037695,1.3370369e-33,0.113208786,-0.07868858,0.0028452799,-0.064835705,-0.024864526,0.024437578,0.05499313,0.0011939642,0.04198333,0.016510088,0.0507016,0.07496817,-0.07503721,-0.051939406,-0.0036128315,0.050097294,-0.025429618,-0.0041436506,-0.043560978,-0.021064984,0.005204117,0.08092469,0.047577787,0.064204186,0.043739766,-0.037501153,0.027853243,0.043042816,0.03462824,0.099407524,-0.03305849,-0.049368855,-0.039064214,0.01196831,-0.024453832,0.10139976,-0.04604263,-0.0063216467,-0.0010952542,0.03728214,0.04346583,-0.033221312,0.013753553,0.019218015,0.07916693,0.08738504,-0.059434064,-0.040897347,-0.09868947,-0.027061073,0.027025657,0.0043298188,0.05488658,0.06104453,-0.0348019,0.079427175,0.038353723,-0.022874452,-0.017682446,-0.036149234,-0.008274462,-0.019010708,0.022867197,-0.046001095,-0.0915045,-0.016262505,-0.07291534,0.009526274,0.03955715,-0.0048533436,0.07150772,-0.04166592,0.01796034,0.08834371,0.030577421,-0.03841027,-0.07657678,-0.05012209,-0.035518654,-0.039829884,0.04586363,0.07191699,-0.012100548,-0.06506158,0.005395292,-0.06246233,0.0026359288,0.09056269,0.025267689,0.014972552,0.021996887,-0.054828618,-0.10936629,0.030842632,0.06410695,-2.2813506e-08,-0.033310093,-0.06420791,0.047826257,-0.031209009,-0.0055907527,0.06117869,0.005266436,-0.010426431,0.04679938,-0.031673815,-0.04339179,0.09115124,-0.007698018,0.0056807734,0.010228116,0.04442329,-0.035542026,0.016384022,-0.09942551,-0.045128535,-0.10020894,0.0008167224,-0.06416725,0.0137097025,0.026721202,-0.05795964,-0.018108135,0.012022232,-0.056642227,-0.03674999,0.017352382,0.055082906,-0.04062512,-0.0013563104,-0.02191852,0.09809927,-0.02625676,-0.0004574359,-0.0018967577,0.100786194,0.024734687,-0.062459487,0.0012067158,0.012578,0.041021056,0.051543895,-0.045400154,0.030842535,0.020576572,0.08303727,0.081339315,-0.036082853,-0.077600904,-0.0534173,-0.06732249,-0.03083241,-0.047510147,-0.1085631,-0.019984882,-0.08337444,-0.008018478,0.06419374,0.2613315,-0.090215914 +1.1.1.206,"Also oxidizes other tropan-3alpha-ols, but not the corresponding beta-derivatives [1]. This enzyme along with EC 1.1.1.236, tropinone reductase II, represents a branch point in tropane alkaloid metabolism [4]. Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [4]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [3].",384,0.99999994,-0.00718474,-0.10966633,-0.15289977,-0.013149611,0.024910474,-0.0218237,-0.029577175,0.050720364,0.070183754,-0.06539772,0.019827671,-0.016107759,-0.02989004,-0.00012909264,-0.005391061,-0.009897248,-0.100916505,-0.019015484,0.112689346,-0.031128319,0.033337627,0.036508992,-0.0025249363,0.07064476,0.051631127,-0.015176035,-0.018691955,0.02360998,-0.019135956,-0.030399844,-0.039610352,0.0071351947,0.013478883,-0.0063284477,0.017886914,0.08630432,-0.13801819,-0.01883672,0.016000422,0.048389982,0.02534371,-0.0076359706,-0.046794962,-0.0030557262,-0.05474357,-0.093062304,-0.034126427,0.08923575,-0.028569339,0.04032049,-0.035053432,-0.014754716,0.013507203,0.13039993,-0.05497448,0.039214615,-0.052854586,0.05037371,0.018262401,0.0822967,0.016161101,0.066525675,0.0019038395,-0.06555605,0.025434345,0.014689796,-0.015336575,-0.07951061,0.055301223,0.019165436,-0.05231598,-0.010894399,0.04318863,0.056739844,-0.001259079,0.008601159,-0.005296428,-0.011132571,-0.11812218,-0.044870485,0.05007264,0.018132629,-0.007859411,0.0066340924,0.04694654,0.0043302355,-0.056093384,0.10274029,0.0014766335,0.005531094,0.11694108,0.008042935,0.04315092,-0.07064119,-0.021751681,0.055369113,-0.013694789,0.040786747,0.036847223,-0.059452206,0.016675908,0.001156377,-0.09628786,-0.005441664,0.018831264,0.07412593,0.035180587,0.020655673,-0.04049072,0.01015464,0.052959498,-0.019454889,0.057408065,0.0025368126,-0.035426974,0.13620783,-0.017600814,-0.05411601,-0.014338069,0.03101786,-0.037014358,0.01600945,0.040571958,0.039416447,0.017581813,-0.0038663407,-0.12290345,3.07055e-33,0.022810176,0.06901406,-0.0046191416,-0.030277355,0.0036662442,-0.006505182,-0.117822364,-0.03904779,0.012185793,0.0071399235,-0.1143919,0.027653638,-0.00077657064,0.0017941453,0.07423311,0.012146645,-0.035960574,0.08948544,0.07818762,-0.028142344,0.017550379,0.055367924,-0.13885805,-0.007024137,-0.02349474,0.055165257,-0.052127104,0.09191814,0.025148226,0.0015826701,0.045770507,-0.075085714,-0.042605445,0.03905211,0.034017943,-0.061290886,-0.042466015,-0.0025656323,-0.081655204,0.101613075,0.012652273,0.09471807,0.037966464,0.027171377,0.06515548,-0.06144082,-0.0055916663,0.069083415,0.075071506,0.04399782,-0.01976731,-0.032886375,0.054091692,0.004556277,-0.065405264,0.030397998,-0.010219385,-0.039544925,0.07059053,0.09443251,0.012380607,0.027815925,-0.024365457,-0.06188328,-0.057739794,0.026099324,-0.03292343,-0.08137909,-0.05579351,0.06553254,-0.112357475,0.027093627,0.05512303,0.04190797,0.10026029,-0.028108893,-0.03400103,0.0027962832,-0.03464301,-0.051159397,-0.037000023,-0.06260834,0.0104019195,0.016974088,-0.030817509,0.01796082,0.031413976,-0.023733452,0.005105407,0.041300092,-0.007599811,-0.034478683,-0.116097726,0.008229376,-0.023909649,-2.7332213e-33,0.028103013,-0.057777017,0.065212965,-0.10524658,-0.07798262,0.089323014,-0.026791878,-0.10159196,0.02473858,-0.021461416,0.067719206,0.025448725,-0.03809241,-0.04258261,0.04721948,-0.0040448545,-0.0052171797,0.0405636,-0.014441177,-0.04385077,-0.05302983,0.040785044,-0.06345483,0.050098583,0.016869117,-0.019936426,0.057991333,0.06961638,0.07106291,0.09882856,-0.046530984,0.009569887,-0.06588588,-0.009286682,0.00051116175,0.033798575,-0.10006913,-0.014556012,0.017677747,0.038344134,0.039505232,0.0065968856,0.018551363,0.0148696955,0.031819914,0.007235558,-0.057067446,-0.00773281,-0.025047919,-0.07763631,0.058572385,0.027959343,0.02160825,-0.020956304,0.07002202,0.009498976,-0.04174308,0.041703656,-0.006987886,-0.06636071,0.046365853,-0.025374223,-0.0066308333,-0.036683746,0.04735896,-0.0022956214,-0.035698626,0.07279932,0.03894624,0.057631593,-0.0270038,-0.0160946,0.008940325,0.040950913,-0.03664577,-0.033651084,-0.05423019,-0.048122086,0.06545808,-0.006483765,0.008411822,0.04731182,0.024057085,-0.09277524,-0.019819008,0.06623184,-0.014163399,0.13291642,0.05883183,0.040039036,0.07722917,-0.026968736,-0.030773655,0.022203404,0.024503376,-4.4329955e-08,0.043566488,0.0026090634,0.004830186,0.04248597,-0.011559129,0.028087683,0.014263863,-0.033865638,-0.023844056,0.0024511106,-0.07551576,0.038182113,0.027206318,0.009405227,0.0424679,0.040108465,-0.085448965,-0.008134964,0.00962591,0.058986213,-0.066060126,0.026496954,-0.085411124,-0.007493516,0.05636462,-0.028696157,0.01671193,0.026175536,0.03255182,0.038996514,0.042008374,-0.021022344,-0.03762949,-0.023653451,-0.029339312,-0.024786927,-0.07642868,0.029679937,-0.07030621,0.04919716,0.026871292,-0.05585778,-0.049452797,0.034244318,-0.010054513,0.018639846,0.046014965,0.008370636,0.04159877,-0.04284652,0.025682848,-0.051852915,0.013145028,-0.067135766,-0.10937604,-0.061625622,-0.058069088,-0.07981437,-0.061577372,-0.060782954,0.032294154,0.015770646,0.18074253,0.0040239454 +1.1.1.207,Not identical with EC 1.1.1.208 (+)-neomenthol dehydrogenase. Acts also on a number of other cyclohexanols and cyclohexenols.,384,1.0,-0.06598583,-0.03530374,-0.024677197,-0.045535192,0.044264816,-0.002244851,-0.075397305,0.0027079943,0.02480493,-0.06461964,0.023530003,-0.08786953,-0.055927824,0.015729751,-0.05209196,-0.0025172783,-0.079359874,-0.076920174,0.003396695,-0.008574205,-0.0058796336,0.024497833,-0.017758286,0.03161076,0.05771882,0.01988366,-0.0031351622,0.058255203,-0.040758904,-0.038863618,0.053381737,-0.00199359,0.03512487,-0.011175927,0.036633287,0.03922792,-0.03381186,-0.03800314,-0.007259725,0.028720351,0.03385239,-0.024484769,-0.054140918,-0.010320795,-0.04795488,-0.047302168,-0.073926106,0.059749026,-0.011920279,-0.005951435,0.057713766,-0.066012576,0.011341793,0.04357519,0.070152886,0.036691155,-0.07571575,0.023156757,-0.044465937,0.028470453,-0.00989544,-0.015172687,0.010615116,0.07766622,0.01678675,-0.010988969,0.06263422,-0.14431007,-0.030721648,-0.011177806,-0.056458227,-0.06849259,0.0010210677,0.03506101,-0.061806273,0.1088151,-0.043484952,-0.013969293,-0.01349999,-0.082326226,0.041115306,0.009601522,0.0096786115,-0.024846839,0.034672864,-0.015552376,0.04658556,-0.054241773,-0.018841809,0.06037991,0.044548832,-0.024069294,0.015681915,0.012182492,0.0148222,0.056780934,0.1120393,0.12596323,0.022847787,-0.06836017,-0.03058905,0.10421842,-0.055036668,-0.019323988,-0.047387294,0.012336261,0.013478095,0.048155855,-0.07574411,-0.021516526,-0.02367556,-0.12730893,0.05810558,0.007196929,-0.0071782507,0.08857924,0.03511001,0.008237175,0.0034828642,0.0040258444,0.024592945,-0.039574027,0.042589936,0.082613386,-0.005242537,0.120759286,-0.09518414,4.910485e-34,0.041950867,-0.009145542,-0.022901917,-0.030825997,0.04026873,-0.01110677,-0.073290996,0.0837324,-0.06445033,-0.03533869,-0.04979717,0.08744953,0.11570594,-0.048613414,-0.048013404,0.012031975,-0.020055728,0.016937587,-0.003721748,-0.014707272,0.029373756,0.051733594,-0.069416545,-0.030501714,-0.052955166,0.03797231,-0.03979834,0.0011076411,0.027454989,-0.0009422258,-0.06745884,-0.123107694,-0.059487097,0.04181665,-0.028059972,0.0077689444,-0.00882924,-0.0712855,-0.0035184305,0.009431071,-0.040960126,0.022633329,0.009528571,-0.11214351,0.00874674,-0.062394496,-0.070890434,0.020276498,0.00239271,0.049018126,-0.011745406,0.017661588,0.044754148,-0.06515572,-0.05303179,0.0049263462,-0.007283345,0.08042974,0.012451054,0.08943211,0.017229699,0.13177878,-0.033768356,-0.034899544,0.038947027,0.016971026,-0.08551025,-0.024095353,-0.06507287,0.05132423,-0.057220478,0.021904904,0.1324043,-0.025666624,0.10054855,-0.009032153,-0.03082184,0.04244417,-0.016511684,0.06183742,-0.11160588,0.01800634,0.017411131,-0.008099571,-0.028812934,0.034502964,0.0012945042,0.011925539,-0.010193666,0.082933255,0.05689662,-0.09314193,-0.049384426,0.008746726,0.016098661,-3.215299e-33,0.028064255,-0.015873801,0.005480363,-0.10571863,0.015522831,0.14825265,-0.008517659,-0.056544155,-0.008978896,-0.0033077754,0.12676124,0.056721244,-0.040443018,-0.06153885,0.00813795,-0.04717714,-0.039563164,0.037404254,-0.030878255,0.039164554,0.027617572,0.067018315,0.023069846,0.08346805,0.05468766,-0.023887929,0.044341248,0.056175545,0.032917902,0.011670465,-0.06614187,0.05895569,-0.029526103,-0.008844423,0.011000147,0.042800337,-0.057734653,-0.029791806,0.057807993,0.010490654,-0.063635126,-0.0076979874,-0.01807066,0.040750757,0.13226752,0.06203827,-0.04929521,-0.035595886,0.019834023,-0.039381325,-0.021523243,0.0878064,-0.060965665,0.08190798,0.025506306,0.058705945,0.046132475,0.057712924,-0.0021576954,-0.013190293,0.0012184866,0.022490377,-0.0028587177,-0.019416548,0.0048500546,-0.0014214166,-0.0686027,0.021379603,8.157702e-06,-0.00839516,0.060201954,-0.06706622,-0.066996135,0.030260604,-0.024178006,-0.08294556,0.036364608,-0.049578853,-0.036907867,-0.055351473,0.021898504,0.049060676,0.015568486,-0.02360555,0.035722718,-0.020532062,0.020788385,0.060752727,-0.04987408,0.020807134,0.0074080015,0.046082385,-0.1178663,0.043386284,0.034912698,-3.253014e-08,0.051580857,-0.026509786,0.032451734,-0.028423674,0.069047,0.0016338582,0.002894944,0.0018328084,0.011848483,-0.040482357,0.030905085,0.0333338,0.0711216,0.037442032,0.06722853,-0.035139516,-0.065036505,-0.0294563,0.005214347,0.05126819,-0.047267403,-0.03342635,-0.10479587,-0.035615716,-0.06320477,-0.08745492,0.05475211,0.0019364378,-0.013388357,-0.035154346,0.003739524,0.024564194,0.0024557265,0.009845497,0.03811524,-0.01913695,-0.053413562,0.030829636,-0.1117784,0.04006157,-0.044868838,-0.121094964,-0.04602688,0.017195717,0.093788736,0.056014035,0.0031116575,-0.06407138,0.032931924,0.005364115,0.038447652,-0.04159801,0.039189987,-0.035719436,-0.03501146,-0.042910185,-0.05764146,-0.08944849,0.025431095,-0.0023491238,0.053777423,-0.03574193,0.16219236,0.022204645 +1.1.1.208,Not identical with EC 1.1.1.207 (-)-menthol dehydrogenase. Acts also on a number of other cyclohexanols and cyclohexenols.,384,1.0,-0.077437274,-0.02877856,-0.05690077,-0.04494205,0.03770226,-0.02139516,-0.07135064,-0.01739124,0.013959614,-0.06786435,0.038888708,-0.0795829,-0.04767419,0.02480939,-0.038231824,-0.02646388,-0.07276044,-0.07746548,0.0321018,-0.025273869,0.036764443,0.029557921,-0.0629618,-0.0067511173,0.022580609,-0.0060470565,-0.043436985,0.1095076,-0.045853544,-0.056798976,0.072120585,0.0015403808,0.09749777,-0.04101753,0.06169759,0.053221647,-0.011908004,-0.052754644,0.01673687,0.024218094,0.01754214,-0.04787473,-0.028982962,0.021080706,-0.018654224,-0.010295246,-0.0433076,0.056196373,-0.0031975457,0.018413898,0.07566331,-0.015634041,0.06022539,0.020264288,0.058961265,0.04961274,-0.10458309,0.028876701,-0.028436424,0.0004031504,-0.013030909,0.0061841486,0.0057292297,0.09356717,0.0048598708,0.0023381815,0.044165112,-0.16245073,-0.0037859702,-0.004684945,-0.0146750985,-0.089830026,-0.01053938,0.029387916,-0.06480982,0.11313996,-0.07439459,-0.042831555,-0.03482332,-0.087516695,0.031953335,-0.011501912,-0.011504685,0.019760214,0.014915634,-0.03512849,0.035299268,-0.06933136,-0.026972396,0.07213829,0.024516976,-0.05780312,0.04678249,0.012058015,0.02697097,0.06713911,0.064987876,0.15821081,-0.02877617,-0.058871463,-0.012564539,0.095158175,-0.05999655,-0.04072718,-0.040817786,0.041447088,0.0052715214,0.05864923,-0.044665165,-0.018821804,-0.035546854,-0.08183276,0.015654251,0.0017200018,0.0115101,0.036830258,0.044793356,0.016618585,-0.024901576,0.006371069,0.02881649,-0.04191094,0.02162053,0.06267752,0.028987698,0.1084528,-0.0793926,5.498975e-34,0.02626127,0.0017014329,-0.007032291,-0.062221475,0.025922365,-0.0071783913,-0.06459571,0.061267894,-0.04042964,-0.040166594,-0.034899477,0.085912995,0.10336155,-0.06331038,-0.07440133,-0.0045731957,-0.01939232,-0.021660017,-0.0026773023,-0.0013095048,0.0074053654,0.059666876,-0.097935915,-0.06153224,-0.035090346,0.013753388,-0.016039912,-0.01128252,0.060387716,-0.005099473,-0.07717776,-0.083050676,-0.022197252,0.036576264,-0.012896787,0.0038746484,-0.015459597,-0.04225895,0.01561305,0.032173567,-0.018082265,0.045564197,-0.008781186,-0.09698208,0.04590405,-0.044873882,-0.050374627,0.06866876,0.03800176,0.01709375,-0.006266532,-0.008766775,0.05311125,-0.10632238,-0.015181183,-0.006834353,0.007282531,0.08671994,0.0145974355,0.10879608,-0.009102131,0.12985523,-0.037514847,-0.018984906,0.04029653,0.009098702,-0.06424715,-0.054591276,-0.076239504,0.045005325,-0.054956496,0.026494076,0.12548995,-0.014130291,0.09442607,-0.002924649,-0.029188897,0.078520976,0.019227479,0.043663114,-0.06055506,-0.008002241,0.011749394,-0.019467955,-0.017771468,0.039183307,-0.011059236,-0.054092277,0.005860698,0.08403405,0.061291695,-0.09660278,-0.013434306,0.039621543,0.023275182,-2.9282975e-33,0.0015868987,-0.022700975,0.021592628,-0.04805939,-0.00801709,0.13919128,0.007934781,-0.011521788,0.017056704,0.025478393,0.13824947,0.001649293,-0.04333663,-0.08412376,0.010256465,-0.059609126,-0.009060263,0.01785831,-0.037969176,0.06108522,0.024321986,0.072398484,0.029692413,0.044101086,0.05165408,0.0029526649,0.03122239,0.043079555,0.05114391,0.028793266,-0.06598967,0.03371924,-0.046902936,-0.015483913,0.022182442,0.019987782,-0.1006992,0.029736776,0.0755085,0.0075819516,-0.08303188,0.019644216,0.0030802155,0.011967987,0.11936476,0.110600375,-0.04943615,-0.022332344,0.008191614,-0.06274534,-0.052517455,0.066934,-0.10658198,0.057806037,0.031455632,0.06732371,0.07122011,0.032983366,-0.016816664,0.0018781549,-0.022263505,0.0078685125,-0.005906949,-0.012262948,-0.026754363,0.0023800067,-0.053682406,0.014091539,-0.0043012393,0.0058522183,0.057309195,-0.10384327,-0.0033587487,-0.0019220666,-0.013697788,-0.054642573,0.015654951,-0.045310542,-0.040382158,-0.080023296,0.03351483,0.04141346,-0.027046746,-0.017137226,0.016348083,-0.021346264,0.023214873,0.06746169,-0.05535131,0.07604071,-0.0052781543,0.048825584,-0.1032104,0.031373523,0.05751211,-3.0962365e-08,0.073579505,-0.019578977,0.049894273,-0.029378286,0.064342245,0.0017489569,0.0009972139,-0.01727085,0.06178825,-0.037030324,0.009952457,0.038179446,0.041679733,0.0075970218,0.05472011,-0.020006318,-0.06205443,-0.049420003,0.017449567,0.04671862,-0.048952512,-0.050436955,-0.1115507,-0.0498664,-0.043755576,-0.076637715,0.07299573,-0.01655568,-0.027837133,-0.043816153,0.0030623022,0.032877855,-0.010638716,0.009772173,0.046399496,-0.031197002,-0.052917175,0.05878021,-0.036469318,-0.008960885,-0.05458327,-0.11512904,-0.026318116,0.040851455,0.09573652,0.03448917,0.0065237847,-0.025428759,0.007052675,-0.0039341035,0.025310583,-0.0436489,0.052363515,-0.072574146,0.0020465082,-0.0055309725,-0.05039753,-0.108392306,0.030945158,-0.029509148,0.03160059,-0.05853434,0.11842592,0.036620975 +1.1.1.209,"Acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase).",384,1.0,-0.069576465,-0.07512556,-0.018604135,-0.07917968,0.081666075,0.029120618,-0.066321656,-0.08682974,0.0008473719,-0.0018357444,0.02240588,-0.044083863,-0.081866,-0.024262318,0.01482574,0.050097022,-0.055097774,0.019341677,0.05592921,-0.021254415,0.051849164,-0.007395669,-0.044095915,-0.024807185,0.046878193,0.018898167,0.028367622,0.08574297,-0.05988997,-0.047269903,0.011070422,0.02355158,0.004230341,-0.035613943,-0.08714111,0.09320228,-0.07462561,-0.08219746,0.08903139,0.1145943,0.021253096,-0.062242776,-0.06587958,-0.024517598,-0.022583338,-0.034050316,-0.048041325,0.0671587,0.048784763,-0.016103126,0.008326819,-0.072099075,0.0018987843,0.066643305,-0.050299093,-0.069146246,-0.030217763,0.037022926,-0.06324722,0.06627311,-0.0073853973,-0.035116285,-0.03949806,0.07869345,0.014839335,0.0077879685,0.019585138,-0.07858203,-0.05199999,-0.031132026,-0.029997045,-0.020757506,0.007830457,0.00044427745,-0.08810117,0.0149098355,-0.026618553,-0.05497131,0.019483378,-0.072482206,-0.01904748,-0.03414177,0.07096437,0.08992616,0.008111894,-0.03385108,-0.05166249,-0.0030455238,-0.045441736,0.12734017,-0.027525306,-0.00376318,0.014171184,0.044328313,0.033493586,0.061949156,0.018413173,0.012759797,0.0447939,-0.023960073,-0.0385222,0.08749536,-0.08821682,-0.036965314,-0.098806575,0.020640504,0.0196129,-0.002506415,-0.051138576,0.027799012,-0.014721581,-0.060126327,0.04069484,0.003914073,-0.043724112,0.02792085,0.0075893938,-0.049565054,-0.014580363,-0.09483746,0.010944378,-0.03871482,0.045887627,0.07661247,-0.03736876,0.05152584,-0.07186518,-6.2843736e-35,0.08355224,0.008685058,0.0014850985,0.036599316,-0.043260667,0.1049936,-0.04446814,0.011665862,-0.08357372,-0.014598062,-0.0011294844,0.023997052,0.046557646,-0.030492673,-0.0041058324,-0.04980193,0.045960102,0.063866846,0.028021527,-0.008116148,-0.026153544,0.06874414,-0.07500665,-0.0550866,0.002529088,0.06282505,-0.011310118,0.038478497,0.027734453,-0.0022090604,-0.044666007,-0.09912518,-0.06591127,0.041415114,0.047328755,0.01315776,-0.024339018,-0.0037935367,0.009862476,0.054048996,0.0645889,-0.044605378,0.014026047,-0.07396665,-0.019877302,0.029789692,-0.025435762,0.05363021,0.096484326,0.05359869,-0.017210634,0.009368629,0.030275233,-0.033043254,-0.044565227,0.066910386,-0.075199105,-0.005888242,0.008336107,0.059908282,-0.027639726,0.02325626,0.04328191,0.012781142,0.01015244,0.0077060275,-0.030866554,-0.073622786,0.001768132,0.027594505,-0.032885898,0.045112263,0.13996296,0.030411692,0.041411024,0.107396975,0.019743778,0.024564598,-0.0074982103,-0.0019239987,0.008458799,0.009513006,-0.038364254,-0.033052377,-0.045979943,0.099086806,0.021992378,-0.029583018,0.057618506,0.047646314,0.034719203,-0.1342675,-0.02045725,-0.0042027677,0.04719896,-2.5406784e-33,0.071157664,-0.121103264,-0.037421513,-0.11816478,-0.016769301,0.09647921,0.064809464,-0.039046478,0.022173742,0.089323774,0.06681182,0.010815758,-0.06402063,-0.13296722,0.018030282,-0.025326002,0.045104206,0.05376242,-0.046436094,-0.07369674,0.06677425,0.061720364,0.03351152,0.120735906,-0.01718996,0.059153203,0.048257705,-0.03783834,0.049735866,0.12022544,-0.050344598,-0.024591874,0.008615418,0.029769262,0.067027114,0.06456499,-0.06729658,0.057492062,-0.011649844,-0.012919136,-0.05596144,0.037284803,0.027649676,0.009968844,0.04485841,0.066303976,-0.016751323,0.02685725,-0.013078495,0.020328214,-0.03343407,-0.06969292,-0.021385295,-0.023851814,-0.012882182,0.018733844,0.014709835,-0.0037958664,0.030798333,-0.0503482,0.0377549,-0.017958002,-0.007877197,-0.010673683,-0.047089543,0.019005634,-0.0359608,-0.09630049,0.027779635,0.074925676,-0.010127103,-0.077505484,-0.0004334868,0.07082453,0.0128781665,-0.067775875,0.008505987,-0.06933067,-0.037683155,0.03602805,0.03689318,0.05781834,-0.06994899,-0.019006653,-0.004984988,-0.035445437,-0.0040197554,0.11801266,0.016620666,-0.009263099,-0.01889939,0.042069953,-0.11394884,0.0077458136,0.019553833,-3.486506e-08,0.051753286,-0.07258733,0.11859167,-0.025020454,-0.014323874,-0.0107718725,0.06635363,0.012639375,0.09464759,-0.07442278,0.03997037,0.06120328,0.08429843,0.01777715,0.08439737,-0.059371963,0.013103745,0.026338555,-0.01787667,-0.09131097,-0.016387984,-0.05906203,-0.06315999,-0.007346367,-0.032982856,-0.031012358,-0.02941304,0.025470257,0.018729195,-0.014362489,0.028734418,0.011456126,-0.0074621555,-0.044253707,-0.012657142,0.046605766,-0.020177962,0.008588202,-0.008180768,0.028479736,-0.056229655,-0.0865572,0.021987498,0.058021367,-0.016011342,0.008862606,-0.031818137,0.024492782,0.041128226,0.023108603,-0.024415014,-0.008600066,-0.002937025,-0.022374095,-0.07609139,-0.024653263,-0.053479634,-0.10478605,0.0039148005,-0.05787497,-0.014336404,-0.01683052,0.14594822,-0.024694368 +1.1.1.210,Also acts on 20alpha-hydroxysteroids.,384,0.99999994,-0.001906476,-0.02191301,0.041943964,-0.027810453,-0.0441411,0.021207836,-0.0044016116,0.06515848,0.0049436823,0.0032997932,0.04244579,0.07671361,0.030012824,0.06391887,-0.0017041108,0.0836113,-0.017611042,0.04922526,-0.02977823,-0.046849605,0.042188987,0.002555201,-0.014452596,-0.029918736,-0.016082697,0.00088000426,-0.013827708,0.017400939,0.024774663,-0.0150010185,0.057688568,0.08397189,-0.060354862,-0.0033654762,-0.08537008,-0.0025802632,-0.05930352,0.024085525,0.048633542,0.06652252,0.06633952,-0.08087368,-0.010470208,-0.011746443,-0.022185856,-0.0171814,-0.046716787,0.04189661,0.05163553,0.054446694,-0.0036093856,-0.09784878,0.011998761,0.070172936,-0.04156869,0.035855,-0.103379816,-0.00022434059,0.026974555,0.0073349364,-0.09035825,-0.047074456,-0.018151142,0.03466506,-0.036533546,-0.020100089,-0.026822519,-0.027341861,-0.028903812,0.023536893,0.0495661,-0.085491344,0.033086248,0.04450059,-0.14147446,0.004433489,-0.015541588,-0.10749012,0.032124925,0.011025183,-0.044918977,-0.0047301687,0.03513175,0.058618803,0.055587545,-0.023689093,0.008816941,-0.011904231,-0.09779674,0.0933493,-0.007963386,-0.05070097,0.001651445,0.058072448,-0.0026054797,-0.0013082242,-0.0057914727,-0.017908826,-0.054088216,-0.0111035975,-0.045567423,0.027090264,-0.005019112,-0.043058038,-0.052924186,0.0218552,0.04087257,-0.062445708,-0.041308418,-0.014665184,0.004462971,0.00788147,0.029291704,0.024501005,-0.014005116,0.086032964,0.050376102,0.0011099278,-0.012996552,-0.14229125,-0.04934871,-0.081550874,-0.021946166,-0.029027332,-0.03213656,0.05716728,-0.02197634,-1.3864092e-33,0.024749244,-0.05852657,-0.013838011,0.03385375,0.029612865,0.07050566,-0.015038757,0.016885145,0.0028183956,-0.020768827,-0.017181609,-0.029693909,0.02943932,0.03392398,-0.04721832,-0.06591276,0.002264088,0.0734502,0.025899366,-0.071026005,-0.03252421,0.045857314,-0.06581949,-0.039556477,-0.10018582,0.025143906,-0.034896594,0.0009339588,0.04935267,-0.012611304,-0.0051386864,0.018934954,-0.05164594,0.074408166,-0.048399996,0.080030195,-0.033214934,-0.036051627,-0.02328675,0.001240427,0.050698042,0.009024512,-0.035828732,-0.037207972,0.03198948,-0.048201308,-0.06391839,0.011206277,0.090967074,0.034918357,0.09076385,0.033628754,0.022134436,-0.052373838,-0.032622505,0.050907653,-0.04686431,-0.02588469,-0.012124241,0.058196194,0.0111645805,0.03199727,-0.009373647,0.006054192,0.051676903,0.09589627,-0.039813314,-0.0836409,-0.085418105,0.05391943,0.0336965,0.020523855,0.1287389,0.02819194,0.045560203,0.008594011,0.055119686,-0.016485529,-0.025401635,0.031571105,0.04695394,-0.038051583,0.0528064,0.04230561,0.022665903,-0.0017636941,-0.018314444,-0.05746578,0.021676593,0.01109334,0.08971685,-0.14120282,-0.09111062,0.055236313,-0.06389888,-1.10605e-33,-0.031084886,-0.10255899,-0.03322647,-0.044002354,0.037738916,0.105598964,0.0575124,0.040989783,0.012485869,0.006091506,0.035978176,0.0124122165,-0.05314382,-0.052135345,0.00781598,-0.04462616,0.036348633,0.017208569,-0.08253374,-0.028695716,-0.01108956,0.098126814,0.03789576,0.17323978,0.046701685,0.0355408,0.026175816,-0.019935334,-0.040883645,0.09552676,0.009860838,0.0005989116,-0.053789202,-0.02893454,0.04877676,0.051032044,-0.061452407,0.0006296767,-0.042038362,-0.109017104,-0.05744161,-0.056657072,0.10732156,0.073948964,0.047534857,0.03823076,-0.016760247,-0.0102463,-0.0913845,0.023209978,-0.05852675,0.055649817,-0.0041438113,0.033761587,-0.0063820733,0.0007664963,-0.052452255,-0.09360468,0.055862192,-0.08532394,-0.02042697,-0.021796146,-0.07756425,-0.046060856,0.031612888,0.053248998,-0.06470631,0.030973332,0.050804365,0.054574974,0.085230626,-0.0060548997,-0.040337577,0.03849808,-0.025607241,-0.043749955,0.05201562,-0.0836759,-0.017739175,-0.009203488,-0.024560392,0.029193023,0.0061301403,-0.037634328,-0.002181165,-0.0604598,-0.065373264,0.0004634547,-0.019192116,0.095547944,-0.012181487,-0.026544513,-0.13491435,-0.0009539088,0.036075555,-1.7821693e-08,0.056602605,-0.043018233,0.08156132,-0.01587656,-0.031151628,-0.0794564,0.007935321,0.07127119,0.081472725,-0.025147103,-0.004325862,0.07352443,0.076619744,0.03494711,0.035661258,-0.078207724,0.023213211,0.047114786,-0.05366461,-0.067994684,-0.119084,0.0011916964,0.037819657,0.053501744,-0.026078139,-0.019541465,0.056942407,0.08587528,0.028344054,-0.0018880392,0.06710192,0.00510562,-0.046232305,0.008899864,-0.0037587069,0.07776097,0.0377619,-0.02779563,0.023336835,-0.0029793784,-0.05243615,-0.075426795,0.038483355,0.06878363,0.010302313,-0.03135572,-0.032486595,0.0033632063,0.029197173,-0.044824388,0.045829263,0.017323121,-0.0118836835,-0.046582498,-0.11260004,0.008261424,-0.021832736,-0.08757322,0.048513558,-0.031619914,-0.026281899,0.058820724,0.17021072,0.029794477 +1.1.1.211,"This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase).",384,0.99999994,-0.045409363,0.00241563,-0.065900914,-0.059862714,0.026908472,0.007983506,-0.12833789,0.02902659,0.011299434,-0.06340469,0.047249086,-0.071474686,-0.012450332,0.0003236181,-0.054584507,0.007018209,-0.03416491,-0.042291462,-0.00855818,-0.073394,-0.0054176217,-0.021849107,-0.0197321,-0.0160359,0.034372505,-0.05327368,0.07270003,-0.024969399,0.009558123,-0.03800681,-0.019607523,-0.043506052,0.02874538,0.015296382,0.0019342572,0.15018734,-0.05091844,-0.07466522,0.0405828,0.0055798236,0.06754248,-0.011411869,-0.041779477,-0.00086280063,-0.06506857,-0.044108845,0.020617522,0.017128907,0.070138514,0.02437083,0.00027239765,-0.044051606,-0.03358074,0.047934096,0.002358184,0.010142432,-0.07059477,-0.03898329,-0.042728197,0.110013075,0.021562636,0.009524965,-0.006147966,0.033125326,0.02999716,-0.065042906,0.06918554,-0.05673197,0.025946692,-0.0801352,-0.028681142,-0.07937251,0.013554884,-0.024290329,-0.058020014,0.0121409455,-0.037706885,-0.08350747,0.052391354,-0.046786204,-0.009382669,0.025259847,0.025661545,0.079970695,0.039553557,-0.0028314623,0.03959722,-0.04202786,-0.008418077,0.0843076,0.06546351,0.016035553,-0.08975663,-0.022386184,-0.10875259,0.066539414,0.0672111,0.099800885,0.008337036,-0.039429285,0.048749577,0.086153395,0.0038665794,-0.05860921,-0.048114788,0.025377212,0.0046127886,0.09848609,-0.008867635,-0.018841699,0.0029374405,0.015908126,-0.005410907,0.03302013,0.02338086,0.11802653,0.03377172,-0.067005046,-0.0053703245,0.0523811,0.034103666,-0.0012056525,0.071287006,0.006203967,-0.004433306,0.06296458,-0.02488221,-1.2855524e-33,0.04309702,0.012413662,0.032011822,0.007298899,-0.03130066,-0.020279322,-0.061814725,0.048217464,-0.104422554,-0.02348936,-0.011600443,-0.021896368,0.013926132,0.0022331255,0.028434897,-0.062178157,0.001133155,-0.020495402,0.058416173,-0.014099376,0.0009992634,0.030468818,0.0010405197,-0.082273655,0.05658353,0.0133756865,-0.0230208,0.06529407,0.10809392,0.022903252,-0.018404476,-0.102615565,-0.067476854,-0.023555094,0.008187491,-0.0036888367,-0.06730278,0.00097066676,-0.051447153,0.10300105,0.049910102,-0.030253708,0.04610358,-0.09387694,0.036446024,-0.06849431,-0.0298162,0.060924664,0.0045806207,0.041813668,0.07704969,-0.057384495,0.11771275,-0.06720812,-0.0138861695,0.05116546,-0.032451972,0.011533983,0.06333876,0.037254065,0.07509397,0.061373793,-0.0554598,0.08989461,0.10549652,0.0066570225,-0.09571049,-0.06602503,-0.05641872,0.03886055,-0.072293535,-0.045470875,0.028691126,-0.0049454514,0.07509248,-0.011958977,-0.07350044,0.027090944,0.023694342,-0.059380595,-0.010855208,0.03911906,0.04095135,0.021036722,0.015609249,0.021345438,-0.019763859,-0.0022537843,-0.017730946,0.057755888,0.0689482,-0.07812087,-0.03234324,-0.022676468,-0.016425397,-6.241174e-34,0.079231374,-0.1066048,0.047939636,-0.13405846,-0.07566885,0.13443005,0.033625584,-0.0070645427,-0.0058546723,0.03322676,0.09686114,0.03789939,-0.018847818,-0.046417613,0.035901614,0.04367765,-0.045777623,0.032967366,-0.033988696,0.0012755689,0.04445627,0.023860028,0.010892137,0.062018525,0.0137984445,-0.0119552,0.01679986,0.021468334,0.08193161,0.02190601,-0.07467936,-0.008740924,0.03965029,0.03927306,-0.03552319,0.016489685,-0.05504233,0.0019444317,0.08250173,0.037278935,-0.059921663,0.054967657,-0.033796623,-0.018509071,0.018496126,0.021194657,-0.0899714,-0.018329997,0.0031920543,-0.040248085,0.008561907,0.004615712,-0.026788747,-1.5887023e-05,0.014568276,0.033670723,0.016876481,-0.016805705,0.069652036,-0.10582219,-0.06465503,-0.031015681,0.0072520277,-0.0221937,0.06703944,0.08301139,-0.081543095,0.049544398,-0.05562793,-0.03310052,0.049507283,0.008663526,-0.06574818,-0.012683559,-0.009175011,-0.0004294666,-0.01670457,-0.016305063,0.0048956145,0.011769544,0.00023949279,0.011971593,-0.058072057,-0.08992,-0.0030851953,-0.10034636,0.07044035,0.045866415,0.059485056,0.018421054,0.040809467,-0.03424152,-0.11646917,0.032872275,0.078157604,-3.612609e-08,0.008650791,-0.035151657,0.073076926,-0.04538529,0.002545422,0.078128584,0.027415074,-0.033216767,0.029336,0.0019660494,-0.034225117,0.064054996,0.018477527,0.0020884103,-0.0056501203,-0.009591855,-0.046148214,-0.0146096535,0.021954194,0.009278497,-0.012484934,-0.028262096,-0.0812316,0.035189714,0.034288634,-0.034152023,0.01531245,0.052179247,-0.035476267,-0.05076609,-0.0037367588,0.06445926,-0.0015811757,-0.033968147,-0.057106346,-0.0015321875,-0.019273806,-0.008909758,-0.08195963,0.11664189,0.057973333,-0.090880215,-0.038857233,-0.044658355,0.05884144,0.026346778,-0.008065367,0.03529997,-0.010255968,0.064032994,0.026794234,-0.015226717,-0.0016004214,-0.043414976,-0.038002297,-0.053382587,-0.006101709,-0.12957154,-0.07859694,-0.1079991,0.051369973,0.078192584,0.16563621,0.008149602 +1.1.1.212,"Forms part of the fatty acid synthase system in plants. Can be separated from EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase.",384,1.0,-0.057348546,-0.03328506,-0.13575177,0.0644619,0.06851997,0.07925762,-0.06863617,-0.012782992,0.032092076,-0.09649849,0.10327402,-0.119937316,-0.017409556,-0.11602799,0.015182544,-0.070399515,-0.07262472,0.005771614,-0.06788063,-0.10181322,0.037740603,0.07873159,-0.028223865,0.010539193,0.029717483,-0.08917049,-0.011039771,-0.040680226,-0.058248084,-0.11281491,0.03149337,-0.08932668,0.12468076,-0.03887739,0.008879427,0.04240592,-0.016009448,-0.124331646,0.05410699,0.019159716,0.034286235,-0.026060577,0.007976578,-0.012842596,0.021914355,0.017129777,-0.04402593,0.04046893,0.02031644,-0.08980075,-0.018873401,-0.057095915,-0.053855795,0.07363937,-0.023179242,0.015500007,0.01924027,0.055144098,-0.052936174,0.0348915,0.045161206,0.042372372,0.015732318,-0.025059538,-0.045046765,-0.049895596,-0.020303817,-0.060978018,0.05444694,-0.033226196,-0.05677761,-0.09739249,-0.025882822,0.037625987,-0.026936831,0.090986095,-0.049055576,-0.009208298,0.039053395,0.011906118,0.017663393,0.0055725016,-0.052802037,0.013343041,0.014855087,-0.021572944,-0.024152867,0.039878882,-0.037754785,-0.023146413,0.031188956,-0.061597414,0.008906324,0.08567471,-0.03445318,0.06314225,0.032690022,0.0051338254,0.07577846,-0.06973926,-0.032250967,0.060642928,0.01867591,-0.06729985,-0.09978162,-0.002125946,-0.065637,0.042534743,-0.03726513,-0.0138358865,-0.015907753,-0.07739266,-0.013335756,0.0026644072,0.028035052,0.028536147,0.0070649525,-0.087028034,-0.03413127,0.02742441,-0.030176634,-0.046348497,0.023505474,0.06747395,0.01628668,-0.056630142,-0.12632203,-1.26470335e-33,0.034925185,0.016150022,-0.02482112,0.0015388969,0.017150896,-0.02426355,-0.030038131,0.03782749,0.011832298,-0.049361695,-0.041206203,-0.039285414,0.029461423,0.024174951,-0.022383561,-0.05426278,0.015552177,0.003798553,0.020286925,-0.023384238,-0.055086683,0.047868505,-0.029495103,-0.05803214,-0.01913983,0.026807522,-0.03481269,-0.103281885,0.067492284,-0.0071162367,0.00010619141,-0.09878479,-0.06258322,0.110951394,0.025372256,-0.001273134,0.018367514,-0.025995573,-0.02317844,0.069491655,0.03948175,0.02821627,0.07121109,-0.0106599685,0.056008205,0.0545964,-0.10278074,0.08745426,0.08491029,0.050116748,-0.009869082,0.022951465,0.15998173,-0.0103208665,-0.016470859,-0.019038305,-0.071525246,0.07106247,-0.013324101,-0.0009179342,-0.028873296,0.12349014,-0.0631168,0.023631431,-0.04354106,0.056711264,-0.14588827,-0.03971643,-0.009129106,0.08656646,-0.0027298352,-0.04208788,0.04302601,0.0016453636,0.062306017,0.0037915353,-0.07821042,0.051931195,-0.057332356,0.040307187,-0.029740646,0.045325544,-0.043090384,0.012551888,-0.029839149,0.0072144503,-0.03331431,0.062175367,0.020495834,0.04724997,0.041381553,0.006641023,-0.03126239,0.01240491,0.02715703,-6.029519e-35,0.08496614,-0.061536252,0.017855797,-0.11835359,0.011985627,0.020403257,-0.025677681,0.02897391,0.06016246,0.045465123,0.016642723,0.01067326,0.027563915,-0.060334228,-0.01662002,-0.018435208,0.00023441766,0.05773183,0.0057813483,0.021861676,-0.04407847,-0.02703747,0.0069139437,0.10313683,0.012874327,0.03501502,-0.01608905,0.058873877,0.033413768,-0.0063345246,-0.011051175,-0.03906181,0.0011659818,-0.0047479896,-0.10485073,0.024310514,-0.09748336,0.00991705,0.013547732,0.054568216,0.0008029363,0.001999148,0.008815247,0.007861594,0.10432254,-0.0099457,-0.010865455,0.06988375,-0.030005,-0.059762087,0.030905617,-0.016570557,0.02157104,0.0110347,0.050955266,0.09290508,0.021227498,0.10467517,0.008444911,-0.07708654,-0.02614278,-0.04612611,0.012987429,-0.0023599127,0.027274325,0.029821375,0.04198874,0.023871768,0.012481925,0.077983625,0.07296435,0.044822056,0.01018185,0.058176782,-0.010334524,-0.07274457,-0.044045303,-0.060183164,-0.056323797,-0.03063488,0.0026039758,-0.040598158,0.018019699,-0.113653176,0.046205543,-0.030785806,-0.018906586,0.041017,0.012042553,-0.0021410033,-0.005868196,0.010558637,-0.010017418,0.08550956,0.05123755,-2.8842964e-08,0.082154155,-0.03246954,0.052648116,-0.0052760085,0.021996532,0.0056379084,0.04172719,0.020497406,0.07034355,-0.0070027597,-0.031695917,0.04606951,0.035752237,0.008726165,0.015401447,-0.021089733,0.027545797,0.09320433,0.031610753,0.022429867,-0.010622721,-0.015290462,-0.09179076,0.013580377,0.033331092,-0.047520123,0.024858177,0.024952592,0.02354238,0.0046466216,0.06564955,0.030765526,0.065568075,0.033946466,0.021762803,0.0144595,0.01665988,-0.045017045,-0.07819703,0.060928166,0.009224562,0.024005203,-0.032235973,0.011027632,0.051145494,-0.03862653,-0.01458512,0.01199558,0.03382062,-0.014253641,0.00039950784,0.013282344,0.0055934475,-0.09568098,-0.084978275,-0.050162546,0.0063790414,-0.058010567,-0.009326054,0.046778284,-0.02945897,0.03722912,0.20153075,0.06031265 +1.1.1.213,"The enzyme acts on multiple 3alpha-hydroxysteroids. Re-specific with respect to NAD+ or NADP+ [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)]. Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by EC 1.1.1.357, 3alpha-hydroxysteroid 3-dehydrogenase.",384,1.0,-0.031664953,-0.060097184,-0.0451651,-0.13859719,-0.0005390484,0.05596444,-0.073619775,-0.020004926,0.020636808,-0.037467107,-0.006751106,-0.043506164,-0.0984276,0.016696332,0.018079117,0.0422191,-0.042472757,0.040852062,0.043167215,-0.037670355,0.08719506,0.0039993655,0.015512173,-0.04037709,0.059622195,0.02629784,0.04943411,0.0640959,-0.059841592,-0.07898801,-0.01247728,0.0574841,-0.007974004,-0.018136142,0.030568646,0.08893665,-0.16456133,-0.052040875,0.013339461,0.08207635,0.04207656,-0.015058985,-0.03393365,-0.02227343,-0.046423487,-0.06756739,-0.071103625,0.06818964,0.0077587427,0.021271298,0.02185717,-0.050591934,0.015779566,0.051662244,0.013245178,-0.014254598,0.023651794,0.052670233,-0.014582864,0.03162275,0.014893529,-0.041401412,0.021386266,0.017571228,0.11304305,-0.006294416,0.044163406,-0.09523462,-0.056889307,-0.03611913,-0.10442349,-0.033394262,0.024545277,0.015406575,-0.031219032,0.0022829482,-0.03447435,-0.0017129437,0.062849574,-0.04793624,0.0140762,0.053635057,-0.038678665,0.04526051,0.100309774,0.009686421,-0.07771475,0.0056581,-0.017114835,0.015065353,-0.05515975,-0.07539903,-0.024997303,0.044616006,-0.01744374,0.063744545,-0.005466417,0.004894911,0.023809046,-0.06741532,0.029497571,0.09003581,-0.012593596,-0.0034691314,-0.029462334,0.020951916,-0.04484026,0.11511172,-0.07781726,-0.018822264,-0.034443315,-0.050253786,0.07969115,-0.029094517,-0.03751625,0.15626663,0.034756918,-0.04936987,-0.03071171,-0.060624387,-0.009836886,-0.022358928,0.027522366,-0.016641561,0.018461809,0.082015336,-0.11205045,2.2541528e-33,0.09883924,0.008000567,-0.048451185,-0.0124667045,0.028805617,0.02923381,-0.074325874,0.051594682,-0.09107944,0.018489849,-0.02547049,-0.025805172,0.06598568,0.0062789386,-0.04932488,0.023025375,0.010772929,0.02279331,-0.049665123,-0.027571404,-0.012207886,0.09323583,-0.09560775,-0.024453428,-0.03793309,0.062191892,-0.04280426,0.053488746,0.028783202,-0.012881722,0.039498463,-0.09774911,-0.07615937,0.026754528,0.028356114,0.005825537,-0.04163685,-0.05578314,-0.014885576,0.04708776,-0.034885637,0.06828553,0.022382395,-0.088267334,0.05599617,-0.02780947,5.2541847e-05,0.056734852,0.03315273,0.013320477,0.08708701,0.029448334,0.0809171,-0.096225746,-0.023694113,0.06719582,-0.067204125,0.055153918,0.011925603,0.061867073,-0.0034986269,0.0062259687,-0.031024763,0.06835827,-0.028787255,0.049273163,-0.06443887,-0.03374644,0.038388647,0.08224746,-0.013740871,0.016485978,0.06506287,-0.011177828,0.02687592,-0.01885115,0.0005395268,0.011260387,0.023915341,-0.024311043,-0.065518506,0.014780461,0.0065698856,-0.022703035,-0.09415215,0.064236805,0.025219442,-0.05221443,0.0065638553,0.024828937,0.0829543,-0.027437467,-0.07651658,-0.028593823,0.03595111,-3.996942e-33,0.027536776,-0.020263726,0.011162234,-0.18209422,-0.013819168,0.1139783,0.044995744,-0.059048206,-0.03367352,-0.020986328,0.058945704,0.022209449,-0.036603656,-0.114402145,0.049676213,-0.015005074,-0.06553122,0.029505672,-0.037101474,0.033033162,0.08871544,0.092796504,-0.00080711086,0.06914653,-0.044406854,-0.035681076,-0.013417845,0.05641738,0.04453888,0.035223685,-0.03402311,-0.03740832,-0.06678229,0.03304718,0.082795076,0.027872775,-0.06684486,0.021542221,-0.005180854,0.016709521,-0.030542249,0.015921498,-0.06397659,0.070575304,0.06093446,0.08272612,-0.072756656,-0.009110011,0.012368224,-0.04413553,-0.047197096,-0.008044318,-0.0057191555,0.0076216487,0.01923293,0.033203386,-0.029125255,-0.04813955,0.023473635,-0.015983943,-0.001362652,-0.034100283,0.03518463,0.029062267,0.016534735,0.040645655,-0.012514504,-0.03936094,0.051672567,0.02441397,0.06789538,0.0030311667,-0.032794673,0.042992543,-0.03918661,-0.12147897,-0.09562639,0.011712768,-0.04968151,0.021042233,0.052585967,0.041937765,-0.001258823,0.0010756098,0.02294826,-0.012452582,0.01190862,0.1020434,0.018601235,0.0078015425,0.0022857613,0.04492041,-0.13977507,0.03601051,-0.011109981,-3.9881993e-08,0.07159477,-0.017566549,0.044273935,-0.04116302,-0.017643431,0.009085672,0.017406229,-0.0068233376,0.050471447,0.023739018,-0.012655529,0.11347608,0.045502186,0.016355285,0.08252015,-0.06657561,0.00052146276,-0.0035882774,-0.033477027,-0.008516705,-0.072513595,0.021905698,-0.030114997,0.039282598,0.020380536,0.0014585756,-0.023890954,-0.0017729347,0.06179709,0.031510532,0.013691405,0.044193238,0.0496895,-0.03219543,-0.065574676,0.028574223,-0.044514313,-0.0016324688,-0.035136785,0.028968949,0.00010279036,-0.12391976,-0.02656048,0.040622074,0.03375699,0.0062733665,-0.0035787635,-0.0645367,-0.013376267,0.045577124,-0.008649331,-0.044426814,0.013717848,-0.010992106,-0.085773684,0.003815193,-0.08127962,-0.07749059,0.0017451423,-0.06354996,0.06321329,0.018374681,0.15338624,-0.03221668 +1.1.1.214,"The Escherichia coli enzyme differs from that from yeast [EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific)], which is specific for the Re-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase.",384,0.9999999,-0.092964366,-0.07730459,-0.028798556,-0.07248219,0.004433381,0.027733546,-0.10505558,0.061612055,0.020148048,-0.045591746,0.0015455204,-0.05444617,-0.12117545,0.074000426,0.01576717,-0.034689404,0.0070518563,0.0068559926,0.07495897,-0.034405813,0.06525407,0.012611903,0.0031930823,-0.0337763,0.056172572,0.00019044551,0.075453095,0.057609923,-0.08962541,-0.10983477,-0.024622409,0.002094483,-0.012170649,-0.07480226,0.05010336,0.10765239,-0.053297956,-0.06458633,0.05149032,0.011712984,-0.030326497,0.020786257,-0.07114545,0.018797202,0.011280543,-0.020607099,0.010056914,0.13785374,0.030163703,-0.04144824,0.0066700224,-0.022979764,0.0073828725,0.019507797,0.036129925,-0.009552456,-0.007057974,-0.009515404,0.00046202535,-0.02054832,0.008789039,-0.0672672,0.044549286,0.028053988,0.0066890977,-0.054264266,0.08837005,-0.07668403,-0.015288994,-0.022454195,-0.11641726,-0.01691524,-0.011955251,0.05998642,-0.021645334,-0.0037225564,-0.020481851,-0.029267788,0.03436447,0.020635558,0.04700271,0.018196711,-0.035136435,0.04199634,0.0918508,-0.04305409,0.0058384296,0.01031872,0.0040907855,0.042348854,-0.0051837284,-0.042935535,0.012748919,0.0128004495,-0.0730569,0.043178767,-0.013043213,0.083506644,0.010712518,-0.065295115,-0.021412775,0.083034754,-0.0012144977,0.03534395,-0.004665169,-0.02091241,0.023700424,0.11058468,-0.045137376,-0.022275602,0.011193886,-0.046011716,0.037724547,-0.041745257,0.0026474684,0.035732854,-0.017149283,-0.06876465,-0.07727822,-0.0030843655,-0.0069477945,-0.07084847,0.02710802,-0.0009152473,-0.016520644,0.023302434,-0.12227457,1.8919262e-33,0.051534973,0.028861789,-0.03299419,-0.0408903,0.06857164,-0.0061111897,-0.057208534,0.06524223,-0.089461625,-0.021014981,-0.06255576,-0.028038729,0.06528292,0.007948577,-0.03440332,0.046741147,-0.017988503,-0.006118351,-0.030589843,-0.01220665,-0.003252293,0.060060307,-0.01511745,0.010024105,0.013193345,0.044970315,-0.06706406,0.054080456,0.018379198,-0.018240627,0.017249571,-0.09930922,-0.055581495,0.056630522,0.08246753,-0.03362845,0.0027193432,-0.06927351,-0.0052273343,0.03580934,-0.029912578,0.11141591,-0.012458865,-0.06683053,0.07649452,-0.024708832,-0.022567531,0.049266286,0.0019182981,0.076263525,0.03394783,0.043367047,0.09725523,-0.09456977,0.010370514,0.02980669,-0.048714165,0.0859034,0.0017407424,0.091659375,0.0006870326,0.10614136,-0.008844019,0.06863751,-0.012612942,0.05559226,-0.056617644,-0.07133125,0.023029927,0.09101334,-0.035949837,0.027494838,0.044047724,-0.019792084,0.018956942,-0.06657647,-0.013811232,0.028389804,0.04855056,0.014616042,-0.026408134,-0.005507058,-0.051441785,-0.03847061,-0.036150556,0.054776922,0.01617934,-0.034729686,0.0539027,0.058842637,0.09874953,-0.06945414,-0.011038809,-0.043587666,0.07909054,-3.1662047e-33,0.067330636,-0.037179198,0.028930603,-0.13189326,-0.07866511,0.14455359,0.063480765,-0.053448,0.0050725723,-0.029329695,0.067047514,0.017087165,-0.026146505,-0.021455087,0.015535059,0.0096408995,-0.093410715,-0.009841483,-0.04718921,-0.020143986,0.031808585,0.09893277,0.011070353,0.018586043,0.025323763,-0.006347016,-0.019262608,0.097178064,0.041645125,-0.048491053,-0.090710014,0.003489339,-0.060977288,-0.018544368,-0.016075969,0.03549789,-0.12359814,0.021287654,0.012705857,0.07530745,0.012726538,0.057162024,-0.08284673,0.06241757,0.0063841236,0.07688554,-0.073976696,0.014213978,0.086636044,-0.111247845,0.00073723716,0.012907619,-0.03279827,0.009879417,0.0045176386,0.0044774683,0.02338562,0.057828523,0.025000846,0.028472625,-0.00680749,-0.11092605,0.051915783,0.02647493,0.036973167,0.002911202,-0.0023113512,-0.017124008,0.044863354,-0.0013378739,0.019072887,-0.030986719,-0.0015934539,0.032307494,-0.026493514,-0.08389617,-0.09192491,-0.017180102,-0.04394478,0.014776549,0.009439344,0.01721273,-0.05144738,0.010491719,0.0644502,-0.019288162,-0.0018985937,0.038691733,-0.005585905,0.042898256,0.0077351527,0.029942222,-0.06450853,0.037007984,0.009029528,-4.205362e-08,0.073708005,-0.029692331,0.059329517,-0.08137646,0.088391624,0.052739594,0.0016964712,-0.03424959,0.034774777,0.010763441,0.0128898015,0.14930251,0.034856997,0.06052668,0.058731806,-0.009722957,-0.04476131,-0.029221745,0.020689066,0.015563102,-0.027524259,-0.0041928673,-0.13856435,0.039467264,0.022039963,-0.044148155,-0.009630552,0.0075048623,0.009098418,-0.044728827,-0.009556531,0.0050291177,0.076538764,-0.030430706,-0.044593558,-0.025868407,-0.09848534,0.040906716,-0.09364572,0.028516905,0.02139279,-0.070982076,-0.05253201,0.025853822,-0.03111347,0.05777173,0.054206435,-0.020401955,-0.039598126,-0.008900758,0.040097028,-0.04743462,0.013300405,-0.047219448,-0.07122422,0.041212242,-0.035009876,-0.0934012,-0.029098237,-0.027424991,0.06206919,-0.019856535,0.122122735,-0.046646424 +1.1.1.215,"Also acts on L-idonate, D-galactonate and D-xylonate.",384,1.0,-0.040240593,-0.15364136,0.041921265,-0.024603426,0.0013458813,0.017291917,0.010093547,0.037667975,0.027483199,0.018582858,0.0739134,-0.011831282,-0.033292327,0.05252698,0.030564513,0.078954734,-0.029763415,0.037327874,-0.018259402,0.073378526,0.103618704,0.0421062,0.0280066,0.008514495,0.051378317,0.014207735,0.0149266785,-0.004322024,0.008819608,-0.115761705,0.011176879,0.017711936,0.06582225,-0.042086534,-0.023933958,0.04815568,-0.070819736,-0.0050354833,0.03154506,-0.02142319,0.02101222,-0.06686683,0.068050504,-0.03386192,-0.06931983,-0.019458074,-0.091057405,0.022090951,-0.032572944,0.03786664,-0.01989109,-0.118103534,-0.049748022,0.07398567,-0.0127641335,0.03401838,-0.06737892,0.022881253,0.022185318,0.0037863841,0.04149602,0.08286211,-0.004203874,0.032671936,-0.016892591,-0.008164337,0.03703983,-0.014013032,0.0066150404,-0.033999953,0.008174248,-0.074205406,0.014332872,-0.011465401,0.024218574,0.033445023,0.045027275,-0.09633132,-0.0215218,-0.07432959,-0.017372603,0.11072709,-0.0048648296,0.0055942605,0.0146039985,0.0010980385,-0.02842187,-0.0048768697,-0.04268411,-0.014105169,0.065540865,-0.024135467,-0.12861975,-0.019366356,-0.026902918,-0.00266296,0.06509638,0.0286426,0.023742268,-0.018771883,-0.017488632,0.013306172,-0.09533011,-0.052955266,-0.069395564,-0.03236394,-0.0072376304,-0.011811806,-0.078659534,-0.06288242,-1.8694938e-05,-0.05234191,0.035344772,-0.008335027,-0.09141742,0.045315582,0.041511685,0.028337425,-0.07750558,-0.024209723,0.029235305,-0.09321848,0.028388733,0.05417269,-0.022172423,0.036227826,-0.045531403,-1.5167847e-33,0.11611834,0.034700863,-0.07228663,0.0017891263,0.026137555,-0.05316081,-0.071355626,-0.020451643,-0.039005652,-0.0068439594,-0.057702936,-0.0063149263,0.03550725,0.020570071,-0.05410293,0.00096271856,0.022342002,0.033504188,-0.021324247,-0.07139964,0.04407557,0.12007172,-0.06673572,0.024880998,-0.016170057,0.0451312,0.061232626,0.009453037,0.037625086,0.0022470832,0.008770459,-0.08080423,-0.007313189,0.098753214,0.00017487246,0.16218656,-0.120425135,-0.045909107,0.018859675,-0.034913447,0.061322153,0.035410367,-0.09813724,0.0052132444,0.019849578,-0.035425454,-0.05235216,0.01660656,0.05502939,-0.003738496,0.11353864,-0.03566801,0.015472184,0.022857456,-0.019989258,0.05808144,-0.06849154,-0.006060813,0.002429109,0.06843279,0.017251428,-0.0007214894,-0.009918084,0.015256863,0.032060184,0.021650998,-0.07353743,-0.06853363,-0.020982848,-0.0002253207,-0.05795833,-0.11192768,0.15139599,0.034757562,0.005066372,0.003196104,-0.045394287,-0.025386233,0.017461728,0.044837203,-0.012308291,-0.003807008,-0.0048163645,-0.008057767,-0.023001332,0.004192688,-0.032804124,-0.07391965,-0.025731675,0.034277257,-0.023123568,-0.0418305,-0.023052394,-0.06580767,-0.016672105,-5.752514e-34,-0.01977023,-0.031455778,0.034495454,0.043460716,-0.018190568,0.07931821,0.010712385,0.0035727345,0.008546654,-0.04706456,0.06360647,0.026775518,-0.0719585,-0.078015074,0.0033315113,0.043843895,0.07251068,0.06807325,-0.02792909,0.031184426,-0.022318635,0.08108034,-0.014349469,0.05354617,0.06186142,0.023021724,0.017435772,0.004133245,0.08281226,0.060200922,0.03640579,0.03163098,-0.046607442,-0.095302835,-0.056663934,0.06930935,-0.06245254,0.016732583,-0.09446554,0.029637048,-0.021342568,-0.032198578,0.13229682,0.13031079,0.046520635,0.054272726,0.0010766899,-0.011351383,-0.027888333,0.0031169003,0.022811659,-0.03072896,0.002113778,-0.0030249725,0.033916544,0.091884494,0.055108048,-0.027760835,-0.04711671,-0.030731019,-0.010484887,-0.01691819,0.013911897,-0.09922805,0.049248938,0.0030168581,0.0007250468,-0.0054606576,0.008033087,-0.054920655,0.10827166,-0.012873357,-0.02697763,-0.012667422,-0.06952266,-0.07505951,-0.07879005,-0.10496607,0.0012714422,-0.031670045,0.026241187,0.045497213,0.024458038,0.003947572,-0.016579319,0.010879267,-0.03371933,0.09894801,-0.0018138329,0.049633224,-0.0436145,0.03155562,0.01842649,0.0010777694,0.12395169,-2.1978375e-08,0.07599724,-0.017791418,0.045316987,-0.05302835,-0.037023906,-0.027803697,0.028582541,0.048500303,0.019381655,-0.024875173,-0.02234065,0.07952948,0.017355615,-0.03996,0.04931725,-0.037469834,0.04790218,0.08880248,-0.123396635,-0.01051254,-0.06440259,0.0053368155,0.0015209775,-0.076286,-0.05729589,-0.041140247,0.07177813,0.0333964,0.006218561,-0.035062905,0.03525788,0.017756311,0.006525543,-0.04896679,-0.028206233,0.08181169,-0.0026054492,-0.08488804,0.019395374,0.0426057,-0.011946154,-0.027173268,0.02577432,0.0977825,-0.07330158,-0.010474585,-0.048021957,0.007325615,0.0067822724,0.033561908,0.01937637,-0.042804252,-0.03764109,-0.09668861,-0.100207664,0.11044749,0.016635664,0.020006213,0.085942976,-0.046345677,0.027184604,-0.016904715,0.08502096,-0.03566688 +1.1.1.216,"Also acts, more slowly, on (2Z,6E)-farnesol, geraniol, citronerol and nerol.",384,1.0,-0.022700729,-0.12242992,-0.014582476,0.028682662,0.048670787,0.017521394,-0.05987698,0.08296925,0.085174054,-0.06517812,0.037112523,-0.012674417,-0.06756687,0.047290437,0.038532715,-0.013193636,-0.030492092,0.04787122,-0.03915244,0.02513906,0.040508978,-0.03994559,0.045740936,0.0106325885,-0.028762994,0.035863265,-0.015011276,0.03153424,0.067122355,-0.11436255,0.051653,0.11753814,0.01067627,-0.026612243,-0.038793378,0.04765938,-0.050829448,-0.051342413,0.009398216,-0.015614771,0.034561317,0.0023064574,0.011899722,0.030811498,-0.00038003502,-0.013564119,-0.026236536,-0.021551136,-0.002076023,0.031680405,-0.072831295,-0.0752015,-0.057421487,0.0389912,-0.02984764,-0.005821648,-0.09667495,0.05466933,0.04476994,0.019835848,0.0021087157,0.022437895,-0.035002045,0.030950338,-0.057889,0.0659996,0.03458639,-0.06876322,0.020961724,-0.013945236,-0.074112244,-0.011299734,0.03221858,0.017113103,-0.041166414,-0.099399276,-0.008388945,-0.07936881,-0.012897065,-0.09336995,-0.07247143,-0.020721778,-0.044087064,0.0011857819,0.039992105,0.09396724,-0.00803753,-0.010019992,0.01817717,0.057415485,0.09429867,0.04365317,-0.052832667,-0.056639872,-0.00019456269,0.061168645,0.03849322,-0.021902515,-0.008506684,-0.007332131,0.04218506,0.0074283276,-0.03934375,-0.016011434,-0.017556984,0.010840652,0.039971966,-0.038420048,-0.14924735,0.036157403,-0.04676079,-0.009111659,0.047239747,-0.016572235,-0.048407402,0.0030056096,0.013024739,0.03304217,-0.027127782,0.0019848885,0.011271402,-0.022451345,-0.033037562,0.016975315,-0.03830251,0.009613945,0.014923453,1.25026975e-33,-0.046631765,-0.010416139,-0.026152572,0.0004310016,-0.04138559,0.00058413064,-0.100367576,0.032719765,-0.022874705,-0.050468683,-0.030557647,-0.028118955,-0.015249144,0.040321298,0.014764853,-0.07576206,0.053588964,0.02378751,0.021364547,-0.08932871,0.02380533,0.10706594,-0.05762351,0.013985616,-0.0003721325,0.06285213,0.012874253,-0.018321235,-0.028604874,-0.024242027,0.037642896,-0.011966096,-0.00028575116,0.04258438,0.03897633,0.10250729,-0.112956956,0.0026346594,0.014798979,-0.048680447,-0.016591826,0.06349732,-0.13506438,0.07142985,0.030579701,-0.01734059,-0.04833078,0.08441178,0.043469545,0.0033748688,0.06435624,-0.016615922,-0.029414158,0.011645218,-0.020149305,0.05107308,0.056054305,0.0555372,0.024692113,0.062034614,0.019661477,0.045564454,0.04369155,-0.013978187,0.023532761,0.010745749,-0.10541539,-0.03238747,-0.016460514,0.05545493,-0.032108825,0.0031007333,0.10211146,0.045311797,0.056383763,-0.007848355,-0.023197597,-0.1231441,-0.0015899801,0.005975504,-0.06637997,-0.06484446,0.008170003,-0.009038554,-0.054933134,-0.03807976,-0.057669748,-0.03762981,-0.021452002,0.054177996,0.044216592,-0.120138615,-0.017595872,0.022247918,-0.016543781,-2.3893466e-33,0.01962704,-0.044794403,0.055991452,0.043099403,-0.017435906,0.08308213,-0.03376352,-0.04172941,0.009950936,-0.021167602,0.067620814,0.021132985,-0.035817586,-0.06537243,0.026146032,0.051668048,0.10572128,0.04639506,0.074595794,-0.016837876,-0.040360205,0.10496917,-0.0007294232,0.062046707,0.011346398,0.053155128,0.028868504,-0.03637091,-0.0003192001,0.06552708,0.022677,-0.029773263,-0.029044647,-0.067664206,-0.011162217,0.059831895,-0.005718665,0.021605069,-0.10168816,-0.08359375,-0.06934947,-0.011425122,0.08345211,0.07604355,0.039778907,0.08140373,0.012807824,-0.043821648,-0.09970396,0.05958474,0.03600972,0.013486335,-0.10336696,0.022129698,0.07000819,0.009419168,-0.02260815,-0.1630701,-0.036154535,-0.07137618,0.003623866,-0.004493884,-0.0018392034,-0.07208065,0.05724405,-0.00062104507,-0.018115621,0.08777789,0.09056501,-0.039607238,0.106212914,0.011210653,-0.019672347,0.020090327,-0.14353095,-0.055645995,0.096131355,-0.09719754,-0.043680314,-0.074088775,-0.026079534,0.031230446,0.011723471,0.000640922,-0.15922253,-0.021361776,-0.013577959,0.044928838,0.045487158,0.082517855,0.015499697,0.08453144,0.05465423,0.028186936,0.050960124,-2.7405221e-08,-0.014510411,-0.060923643,0.081806906,0.023853512,0.035114106,-0.005079453,-0.0075362283,0.1001214,-0.053925127,-0.046605032,0.040545475,0.03452643,0.07757681,-0.042130828,0.104616545,0.009161196,-0.010196506,0.0458065,-0.028792115,-0.027645739,-0.043070376,-0.0015800934,-0.009406457,-0.07236244,-0.019762265,-0.035892054,-0.0041255727,0.034717057,0.0058636167,-0.04011392,0.056934733,-0.03554929,0.054367606,-0.0045806966,-0.00059107994,0.049329143,0.030969936,-0.044279605,-0.046264622,0.0315136,-0.0041358424,-0.028229693,-0.008197415,0.058879703,-0.054348018,-0.057061795,0.01637624,-0.107984215,0.07734542,0.0030452777,0.050109603,0.032386325,-0.007898217,-0.0049559735,-0.050007287,0.058215197,-0.05444411,0.0014942436,0.024073904,-0.05047213,0.024161628,-0.0049562184,0.06970275,0.050265357 +1.1.1.217,"Also acts on benzyl (2S,3S)-2-methyl-3-hydroxybutanoate; otherwise highly specific.",384,1.0,-0.07214035,-0.062426534,-0.055289626,-0.033386983,0.08283941,0.060035087,-0.0028260273,0.010574255,0.048752934,-0.0676789,0.046056382,-0.033302724,-0.039351653,0.064263046,-0.021513663,0.0811611,-0.05688128,0.0043067513,0.012991215,-0.013469411,0.0301509,0.04647119,0.035819188,0.009201834,-0.029586585,0.017330524,0.061276846,0.009152671,0.03166923,-0.06654632,0.0019277643,0.035887197,-0.019640556,-0.0790572,0.02431585,0.06556361,-0.069213815,-0.050701242,0.058375645,0.07671803,0.053894047,-0.074737824,-0.0068418356,-0.047929253,0.026457412,0.011085419,0.037905663,0.024174737,0.016385153,0.025571989,-0.012458011,-0.041287553,-0.02482107,0.08078767,-0.030208599,-0.00031198643,-0.032529235,0.054279994,-0.001494081,0.049273312,0.0016489364,0.036107507,-0.0020567602,0.043153666,0.033667523,0.028121883,-0.010891488,-0.04083346,0.013057092,-0.054645684,-0.064213045,-0.08284885,-0.0070778946,0.035272956,0.004589714,-0.030131659,-0.011530978,-0.030075079,0.028404078,-0.059339497,-0.025482606,-0.028672352,0.051680513,0.09041905,0.0746657,-0.009862456,-0.06844067,-0.030802984,0.024725374,0.05130305,-0.033009052,-0.025467401,-0.042236578,0.013532186,-0.053096134,0.055446815,0.025663773,0.045193885,0.037537828,0.01968439,-0.03290378,0.02913451,-0.056027368,-0.04995656,-0.006618053,0.013646968,-0.008023293,0.027185107,-0.027054768,-0.027296048,-0.07704926,-0.05001224,0.0329055,-0.057617176,-0.11226581,0.09106741,0.06385422,-0.051634625,-0.043190412,-0.06076528,0.035692398,-0.0034968883,0.015852232,-0.019177048,-0.11216244,0.053799864,-0.10052004,-2.0622995e-34,0.029230108,-0.0020706714,0.025074614,0.016136378,0.014970036,-0.0072242054,-0.08758333,-0.036250446,-0.008081792,-0.02374885,-0.023064246,-0.027622864,0.04206529,0.036623735,-0.02458265,-0.03855832,-0.015383999,0.012966063,0.0013540471,-0.10607079,0.026380537,0.10723459,-0.090879425,-0.045985192,-0.04512313,-0.0105877435,0.039535895,0.0069977674,0.013012385,-0.0074081654,0.019460445,-0.011837009,-0.10032456,-0.009275172,-0.016926516,0.061558306,-0.09064513,-0.075393714,0.0028346353,0.030782364,0.065826856,0.0022290093,-0.008095509,-0.06069263,0.013962935,-0.022430567,-0.0787154,0.08828945,0.06543175,0.0122719575,0.100910544,-0.024920763,0.05042839,0.003983956,-0.042527117,0.035855714,0.0026308207,-0.016155016,-0.0005635492,0.016209481,-0.05145047,0.019332584,-0.03213805,-0.009761028,-0.0059240083,0.016745094,-0.05945799,0.024056533,-0.08978717,-0.029647086,-0.034977287,0.035951972,0.17598024,0.06043125,0.009555699,-0.03273419,-0.046957802,-0.027554296,0.071809664,0.05993667,-0.020045847,-0.05659355,0.12916785,-0.0087365,-0.1201992,-0.036923565,0.007071987,-0.064425565,-0.031440552,0.02134452,0.055942,-0.05756271,-0.07532071,0.021793231,-0.006560869,-2.1368303e-33,-0.01393173,-0.02212444,0.03247642,-0.015592856,0.024482192,-0.0056408513,0.024394395,0.004189558,0.012997463,0.00044328062,0.06882089,0.004708791,-0.036781944,-0.05390396,0.023716247,0.02816351,0.01568759,0.04091892,-0.06332208,-0.022323115,0.05552853,0.024593305,0.0041181277,0.12880738,0.022414047,0.030286558,0.045820788,-0.04535646,0.024923777,0.13124856,-0.039800543,0.008195572,-0.05996778,-0.03651613,0.037950575,0.051953666,-0.01970721,-0.041010533,-0.089327864,-0.029916584,0.0011310753,-0.053085167,0.026562555,0.117744714,0.05281776,0.122034475,-0.031763107,0.014094103,-0.0097995885,-0.03212803,-0.0067652543,0.015154685,0.0088006435,0.084087394,0.06367716,0.06495155,-0.016612787,-0.092554696,0.014321851,-0.03534443,0.02408166,0.02326897,-0.015683778,-0.08978998,0.028486129,0.0092961015,-0.040574554,0.02674609,0.05548722,-0.013834953,0.1519822,0.025434436,0.04110899,0.014120548,-0.10628362,-0.09562393,-0.001799095,-0.07649916,-0.07789308,-0.015527221,0.09624755,-0.006148837,0.01739566,-0.035502188,-0.004515616,-0.07740654,-0.07130393,0.08726492,-0.0029646177,-0.03159758,-0.025873544,0.050786186,-0.11977071,0.07593066,0.028749324,-3.0714002e-08,-0.009317111,-0.06127984,0.058962464,-0.07582699,-0.07082262,0.03768571,0.04362281,0.067439266,0.04037588,-0.088514104,-0.013032464,0.058201298,0.039264146,-0.017295182,0.055690374,-0.05729657,-0.0008715288,0.07369065,-0.059310786,-0.02995857,-0.09262493,-0.0011088821,0.008491925,-0.019762347,-0.029372955,-0.04825648,0.015160643,0.0839509,0.062206287,-0.054674976,0.040945176,0.037566897,-0.017283132,0.02134476,-0.044681564,0.10116288,-0.023194332,-0.05338148,-0.047296185,0.036034394,-0.003899939,-0.013720267,-0.0335693,0.062324215,0.028081879,-0.026198734,-0.077603824,0.059755683,0.010362294,-0.033625063,0.052621197,-0.013486278,-0.008873821,0.023452792,-0.08773749,-0.0028874998,-0.028316282,-0.015961044,0.06712313,-0.07253149,-0.0009271936,-0.0012567479,0.19636048,0.080323644 +1.1.1.218,"Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analogue. Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol).",384,0.99999994,0.014554934,-0.033039335,0.039277628,0.03323292,-0.0078058355,0.022380522,-0.08028804,0.015729537,0.028863823,0.005665765,-0.035773527,0.051093783,-0.05299874,0.026528591,0.007165549,0.11744889,-0.058596008,0.07763822,-0.03548014,0.010539305,0.061816085,0.038111217,0.030889075,0.059700664,-0.015027005,0.11916061,0.021332603,0.03799793,0.0585786,-0.051237375,0.048546486,0.0022076603,0.010092713,0.014504667,-0.0819728,0.02475456,-0.10312024,0.034267396,0.060235012,0.089248456,0.047206555,-0.033739652,-0.06910033,0.0035169127,-0.020658186,-0.055172294,-0.096229315,0.010120465,0.019340493,-0.033290237,-0.0028263452,-0.048194915,-0.022073984,0.08823505,0.020252319,-0.06557332,-0.11820273,0.03194288,0.06200027,0.0802032,0.04638242,0.053468745,-0.008798552,0.054126646,-0.02870392,0.012309126,-0.026194163,-0.04553152,0.003640243,-0.026449164,0.00027805933,-0.035926454,0.10243566,-0.009135465,0.005495378,-0.03718462,-0.026908021,-0.046039455,-0.01759967,-0.07490213,0.041560143,-0.013503764,-0.0039638504,0.086268835,0.06077975,-0.010136874,-0.009051073,-0.011122243,0.004650746,0.020678926,0.06935392,0.0052523557,-0.03607904,-0.053479444,-0.06135825,-0.0523894,-0.034351382,0.060229678,-0.05609518,0.04697982,0.040956583,0.057019938,-0.2093393,-0.07968156,-0.0036570022,0.028273968,0.06268827,-0.034045298,-0.10633995,0.04064165,0.0049131275,-0.03127459,0.026175,0.015407076,-0.06713688,0.09100498,0.00958754,0.012503223,-0.014544703,-0.07701944,-0.039947435,-0.08434571,-0.030234424,-0.014486411,-0.022380654,0.06938293,-0.023047643,4.3358337e-33,-0.001307845,-0.0006823323,-0.023672646,-0.015605456,0.028752606,-0.02539106,-0.056554053,-0.023734862,-0.014610073,-0.012969314,0.021259425,0.07976805,0.0012245036,0.089880966,0.014061573,-0.09822614,-0.0018997814,0.037701566,0.060870342,-0.099718146,0.0067552836,0.045994956,-0.09528332,0.052636594,-0.12980556,0.10013783,-0.055970836,0.036633004,0.03684039,-0.013776928,-0.0016182024,-0.00021043833,-0.03987721,0.0102854045,-0.02597594,0.06064662,-0.04491431,-0.013255125,-0.048615713,0.006435096,0.0032005836,0.047926012,-0.07893738,-0.016167138,0.041999664,-0.04825356,-0.07642337,0.019910099,0.08575628,0.029919663,0.08826954,-0.069962256,-0.034131225,-0.050423447,-0.03716038,-0.0058982866,-0.030765595,-0.054226335,0.083135754,0.050267454,-0.025546536,-0.07497228,0.026787326,-0.03926808,0.040185373,0.02975845,-0.010455655,-0.1295659,-0.07656697,0.008656057,-0.061232995,0.07268482,0.044852696,0.030933013,-0.020255405,0.03457896,0.03452472,0.007368172,0.005320012,-0.014845556,0.02608557,-0.077525966,0.029225264,0.09849363,-0.0067766085,-0.03482293,-0.025830032,-0.07128256,-0.025411783,0.05385191,-0.025972936,-0.090086274,-0.1242342,0.010212069,0.025409725,-5.555422e-33,0.059948243,-0.01803262,0.023184568,0.015896216,-0.041349564,0.0731334,0.054052055,-0.026887182,0.013904603,-0.00090740534,0.07642297,0.028020097,0.06380289,0.0058507808,0.0031129736,-0.057600435,0.04210816,0.05217257,-0.06495035,-0.00721349,-0.012039058,0.07736776,-0.021395255,0.11678265,0.06521453,0.020400329,0.023163812,0.027998926,0.040296305,0.04340349,0.02789298,0.02036654,-0.05638886,-0.12263474,-0.04602094,0.15995124,-0.017687378,0.012947996,-0.096517876,-0.0014372903,-0.028805256,-0.016294856,0.044937246,0.02558221,0.020059155,-0.0027732516,0.020968135,-0.009729203,-0.01705105,-0.003998175,0.06902553,0.00711389,0.01186863,0.07378654,0.045417983,0.024589615,-0.048689943,-0.14775288,0.0074275783,-0.022133838,0.02520392,0.035439156,0.010550726,-0.09132458,-0.048259176,-0.019307189,-0.055566505,0.04952331,0.0124051785,-0.02880619,0.058982566,0.0047589554,0.025244355,0.0022555494,-0.049618807,-0.06530742,0.025243461,-0.08131747,-0.033025954,0.013545491,0.042439047,-0.0006271574,0.006438467,-0.0302412,-0.070861936,0.016312221,0.012923168,0.061324123,-0.012046824,0.050676357,0.02557823,0.022403123,-0.055747457,0.010397021,0.0154850045,-4.3872678e-08,-0.032678258,-0.114721484,0.08607061,0.0006308439,-0.023166087,0.0020109166,0.04370851,0.057711218,-0.08375158,-0.08190369,0.052280433,0.094174825,0.032283477,0.0069790226,0.046037097,0.05232537,-0.0031433965,0.031361375,-1.8913279e-05,-0.0017248965,-0.051898442,-0.07072118,-0.013186392,-0.045229353,0.03322722,-0.06451131,0.05634167,0.03621049,0.01038999,-0.013731605,0.09160095,0.013163798,0.018724583,-0.049857482,0.018351268,0.035769355,-0.02162435,0.0063829836,-0.052403953,-0.014406402,-0.012161011,-0.00064451783,-0.05616222,0.04501587,-0.043323897,-0.0055240453,0.0018007562,0.01910277,-0.019241586,-0.0027900496,0.01763099,0.015531817,-0.023181947,-0.05616955,-0.057163026,-0.07448855,-0.042278018,-0.044923816,0.0043670586,-0.09421993,0.00050482457,-0.023344764,0.14618711,0.0216147 +1.1.1.219,"This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.",384,1.0,-0.09960385,-0.030590199,-0.09677151,0.047927413,0.079686716,0.043864485,-0.01303173,0.026729213,0.044705667,-0.0013845396,-0.018025467,0.010089781,-0.13924077,-0.005012476,-0.073287934,0.025599163,-0.0876166,0.06554485,-0.030562654,-0.015328242,0.01225772,-0.06100844,0.02614452,-0.00681676,0.03995134,0.002900787,-0.0248545,0.030042063,0.010429678,-0.053572133,-2.0766369e-05,0.028287228,0.045333866,-0.057561178,-0.049196787,0.1031431,-0.015903251,-0.07059284,0.03136899,0.016304761,0.058003742,0.023470942,-0.039825555,-0.02511647,-0.024271896,-0.037902027,-0.061041396,0.028249145,0.04548994,-0.004835165,-0.114589505,-0.0110483365,-0.013462922,0.0069135665,0.0816162,-0.041999497,0.01162323,0.038568243,0.0048963227,0.05663266,0.07296917,-0.056683723,-0.041086864,0.007217766,-0.0278333,-0.024854043,-0.041171905,-0.04051364,0.057968687,-0.03023761,-0.07621412,-0.003882745,0.021566955,0.012850158,-0.07511999,0.12869139,-0.062300604,0.045674525,-0.016790655,-0.053019512,0.05705465,0.033988707,0.0012635342,0.038572457,0.002494184,0.0073288428,-0.05107461,-0.0012385973,0.03788413,0.08422887,0.053062383,0.048113387,-0.0062266057,0.012720861,-0.13597482,0.044343654,0.08322632,-0.028560607,-0.043903217,0.00332059,0.018601963,0.05231413,-0.004373851,-0.12372272,-0.06679759,0.02684783,-0.065351784,-0.0454971,-0.03746813,0.018622203,-0.028277278,-0.04954505,-0.008077586,-0.028176019,-0.049956128,0.06836519,-0.024175799,-0.038634572,-0.010832343,0.00087289576,-0.048176397,0.0033821096,0.068197764,0.035966642,0.011533442,-0.021231698,-0.092366725,2.5927925e-33,0.08445527,0.01881277,-0.06379981,0.008148713,0.07722361,-0.014377635,-0.029851517,0.059564464,0.0071161464,-0.0452506,-0.052530684,-0.066562735,0.0051790657,-0.044206712,-0.0482418,-0.0046819365,0.012141691,-0.11405811,0.044256758,0.0392248,0.07830531,0.014268748,-0.130635,0.030798467,0.025209893,0.037960988,-0.009058508,0.01898254,0.025988955,0.0051518986,0.01725491,-0.12600555,-0.08203459,0.03604277,0.041983258,-0.004553028,-0.05559311,-0.05992699,-0.016864078,0.040912542,-0.061029382,-0.058069233,0.0029374596,-0.004953411,0.04195711,0.0217039,-0.04130953,0.050612304,0.041287497,0.0621739,0.030752677,-0.034472346,0.123982534,-0.024673508,-0.09080657,0.041482963,-0.06671223,-0.012165049,0.03162713,0.094211884,-0.00237847,-0.026970267,-0.03523654,0.03202098,-0.032275576,0.051154595,-0.09959884,-0.09000916,0.07681089,0.023570677,-0.017951138,-0.07243717,0.0807106,0.03463558,0.079167485,0.0016595917,-0.0676365,0.007219722,0.0046484615,0.040111102,-0.068058714,0.02054717,0.029700704,0.012891583,-0.024955893,0.044509057,-0.008328002,0.004724488,-0.0032883333,0.004611914,0.03332634,-0.09156308,-0.017946243,-0.005652027,0.060441174,-4.1567218e-33,0.09159425,-0.01999891,0.045721162,-0.03953735,-0.05685578,0.10565337,0.012387718,-0.07823718,-0.050686028,-0.010936193,0.040299483,-0.028409641,0.017155183,0.0047292183,-0.03306212,0.02853313,-0.005361361,0.026961595,-0.020071823,0.04869858,-0.08203091,0.073989496,0.0147247035,0.056347225,0.051474623,-0.040693305,0.06313597,0.014406811,-0.007769363,0.07590297,-0.013950239,0.023602853,-0.07356171,-0.026511688,0.01688402,0.0366361,-0.052985534,-0.017737772,-0.031385407,0.057392582,-0.03293639,-0.045926694,-0.013417993,0.051899385,0.04821386,0.0128523605,-0.09612514,0.033729024,-0.010347086,-0.006805589,0.01306194,0.07415645,-0.04501412,0.09697669,0.057160117,0.040800594,0.03544736,0.026155688,0.024180494,0.006196812,-0.026683828,-0.14432646,0.075509585,0.024630722,0.06411898,0.09303442,-0.00021278457,0.05626433,0.07301652,-0.02955976,0.13199186,0.0075574806,0.0748092,0.09865805,-0.044348784,0.0013702641,0.04599576,-0.05352668,-0.06639453,-0.001133622,0.025078187,-0.014613738,-0.036893934,-0.061220713,-0.07774985,-0.040622987,0.043339163,0.051211644,-0.057283584,0.04536054,0.02832068,0.07358371,-0.06513912,0.056156788,0.073022746,-4.1917872e-08,-0.015357814,-0.053450022,0.025584808,-0.040323343,0.047999766,-0.025647549,-0.00631713,0.024807587,-0.038488876,-0.008598878,0.004319412,0.06866753,0.025825907,0.07948482,0.044853516,-0.00060010003,0.039871495,0.06192543,-0.014386648,0.030620117,-0.05168325,-0.0071917623,-0.14030991,0.0071435063,0.015397951,-0.08983929,-0.0183155,-0.049001895,0.06640537,0.004805867,0.032366063,0.02513924,0.008433387,-0.016443087,-0.07396369,0.01974601,-4.977434e-05,-0.081961915,-0.069850646,-0.01530706,-0.018267663,-0.067297444,-0.015568451,0.014097039,-0.018831272,-0.03754162,0.018133914,0.009219304,0.0050863447,0.056278434,0.05310252,0.042700194,0.041527722,-0.0770646,-0.03220371,-0.004874311,0.01018928,-0.006737779,-0.08520545,0.022399329,-0.06655876,-0.015985401,0.15883966,-0.03265429 +1.1.1.220,Not identical with EC 1.1.1.153 sepiapterin reductase.,384,1.0,-0.06457468,-0.125165,-0.119192354,-0.057191424,0.059569813,-0.09437877,-0.026079746,0.088029325,0.023498058,-0.107160054,0.04467894,-0.072126016,-0.04948411,0.008883813,-0.03531258,-0.05372424,-0.0022430995,-0.084371746,-0.024244828,-0.032553133,-0.052226137,0.011491738,0.004234351,0.07503564,0.05669652,-0.014662944,0.028653938,-0.02201449,-0.04586593,-0.07640296,0.003163241,-0.067252554,0.0652802,-0.021481715,0.022770897,0.047624044,-0.07534739,-0.08164057,-0.024042072,-0.008070836,0.062011015,0.01856098,-0.023427546,0.022506682,-0.0019718776,0.016859438,-0.090322234,0.12903921,0.00782792,0.056116328,0.060292777,-0.052357376,-0.048540417,0.044005133,0.020136064,-0.022272808,-0.084911324,0.020696599,0.031416662,0.07239268,-0.019359592,0.032224838,0.08237758,-0.028163662,0.08236101,-0.0332689,0.06522352,-0.14425188,0.021584319,-0.037971582,-0.00078907737,-0.012644496,-0.0031301042,0.026125995,-0.0058505014,0.040022664,-0.04073604,0.029446525,-0.025808452,0.012558027,-0.022132235,0.026540045,0.0008464191,0.03213944,0.07953484,-0.0503998,-0.020405231,-0.023027884,-0.060669035,0.0074439016,0.09647403,0.00011156078,0.06011273,0.036353152,-0.017903855,0.020449502,-0.03264489,0.10934776,-0.0072798715,-0.012210107,-0.08054564,0.10402097,-0.07673608,-0.006990916,-0.09213879,-0.03845784,0.0114049595,0.029505823,-0.0046442747,-0.014399422,0.0422623,-0.06544463,0.0033558977,0.02883959,0.005708539,0.018708294,-0.0057920977,-5.8763628e-05,0.011815605,0.09675542,0.04631252,-0.080834955,0.04508014,0.028351013,-0.008740472,0.02735273,-0.054958798,1.979656e-34,-0.018885361,0.0011203643,0.024994772,-0.010817169,0.0118688755,0.030147506,-0.07415371,0.067138895,0.003171561,-0.0066547347,-0.049886264,-0.03478084,0.04908282,-0.06997023,-0.07400447,-0.046631638,-0.01807078,-0.01629763,-0.04439185,0.010112272,0.07110146,0.06810627,0.008600093,-0.03261525,0.0558079,-0.014003711,-0.090753704,0.024559414,0.062479284,0.009033457,-0.063957386,-0.058415566,-0.045094844,0.028751401,-0.044461966,-0.0035017093,0.01866747,-0.11056801,0.011308754,0.0735806,0.0018238579,0.07467189,0.019702157,-0.102763094,0.09862586,-0.0017983734,-0.06560071,0.04078701,0.050539356,0.016656332,-0.09079486,-0.010411722,0.09052362,-0.11655469,-0.0053096064,-0.1024284,-0.009825395,0.060902786,0.03776989,0.09375536,0.038835175,0.13033555,-0.046139058,0.03534334,-0.05830343,0.030570932,-0.06459224,-0.0063882465,-0.011013428,0.0025754937,-0.042585127,0.0027028266,0.036161974,-0.07799447,0.012086652,-0.077550426,-0.06759015,0.03491945,-0.0022466346,0.006809924,-0.080340594,0.020223001,-0.018427882,0.0042431597,-0.033028383,0.041137468,-0.014443937,-1.3448283e-05,0.053779066,0.003914247,0.10986624,0.044577625,-0.038598664,-0.035503924,0.036630422,-7.309806e-34,-0.007334475,-0.06422451,0.039567832,-0.08144728,0.035884522,0.06587816,0.023419889,0.047720764,0.08472774,0.0033031672,0.1766221,0.0014609847,-0.12557241,-0.030147959,0.032722183,0.0254781,-0.016483542,0.08208905,-0.020510474,0.024305405,-0.020062687,0.00668249,0.00014782076,0.05107302,0.024439784,0.037052482,-0.0048439475,0.058641188,0.08144849,-0.05007282,-0.0659153,0.023589777,-0.058272474,0.01579502,-0.05865218,-0.0073908367,-0.084347494,0.0152626615,0.023759786,-0.044956654,0.0034577418,0.02005069,-0.034395535,0.034252595,0.050095443,0.054085586,0.021872045,0.084279336,0.06168842,-0.046724536,0.019603457,-0.048036113,-0.009719584,0.05196029,0.0022233145,-0.037586175,0.07353031,0.06303467,-0.034367163,0.00939935,0.0028723413,-0.027192662,-0.051983844,0.030719927,0.0599375,-0.033898905,0.00053966197,0.06737288,0.09727998,0.05730395,0.031324614,-0.048834153,-0.015359337,0.0022840851,-0.06011289,-0.06781467,0.002382289,0.007966576,0.045423314,-0.06781284,0.0043889047,-0.023814468,-0.02828983,-0.035838448,0.06430578,0.060881704,0.038127054,-0.009414795,-0.049058788,0.055831864,-0.053074375,-0.019405626,-0.03421142,0.016100345,0.010518955,-2.0731752e-08,0.17328396,-0.01122127,0.009699522,0.0058645066,0.079531744,-0.028217912,-0.013712378,0.017707746,-0.02721726,0.041997194,-0.027043689,0.024735222,0.08090026,-0.06653803,0.048648622,-0.017328223,-0.029785616,0.048543327,0.014077329,0.06295726,-0.0038115734,0.0036495745,-0.06912114,-0.030167889,-0.06430142,-0.0026069486,0.015791757,0.073069766,-0.022148224,-0.05285472,0.07465334,-0.0539718,0.054931458,-0.016749103,-0.019223724,0.016355922,-0.0064963116,0.046519883,-0.024999231,-0.033330474,-0.08689779,-0.026269015,-0.021932557,-0.004526533,0.019531613,-0.018536542,0.022330403,-0.049681146,0.010497274,-0.016430302,0.021826958,-0.006625006,0.029458798,-0.024915298,-0.017475557,-0.011048251,-0.044311274,-0.03646378,0.013242794,-0.018039728,0.10845823,-0.07075973,0.09631982,0.055345718 +1.1.1.221,Oxidizes vomifoliol to dehydrovomifoliol; involved in the metabolism of abscisic acid in Corynebacterium sp.,384,1.0,-0.07876793,-0.110411,-0.09796812,0.027500967,-0.01256674,-0.038036097,-0.07281988,0.030113572,0.06919172,-0.040278442,0.07230641,-0.05917939,-0.022449553,-0.059781633,-0.08032183,0.062345456,-0.015712213,0.040114354,-0.061362736,-0.04089743,0.0062127807,0.023760248,-0.062157124,0.024937699,0.041533597,0.038485974,-0.051202744,0.029458245,-0.012263738,-0.08166455,0.09666939,0.037812162,0.012342306,-0.0039921403,0.092574574,0.06437808,-0.068172164,-0.08547022,0.16600895,0.045065075,-0.008932604,0.014247307,-0.07556284,0.03232167,-0.1628548,0.030042965,-0.019301316,0.021641605,0.076240554,-0.0051594386,-0.041678425,0.029309673,-0.06831797,0.06469645,-0.022625558,0.10324137,0.030489579,0.04271794,0.032304063,0.008258226,-0.030824129,-0.0634618,0.055679843,0.030193912,-0.11059125,0.013960016,-0.002837714,-0.07309136,0.07702467,-0.044412695,-0.051610943,0.008774514,0.033452313,0.03704122,-0.069124065,0.04561287,-0.022747962,-0.1293638,0.014307893,-0.052215923,0.07142137,0.005939942,-0.032245014,0.043404114,0.04658147,-0.10710545,0.008140518,-0.04020841,0.030143278,0.082365714,0.061944123,0.037548546,0.0866426,-0.09632941,-0.067118704,0.007969721,0.07245447,-0.0614316,-0.03861559,-0.03931045,-0.038080152,0.048216555,-0.04537071,-0.010273249,-0.050376073,-0.06304253,-0.004771112,0.0030123903,0.016038489,0.056405384,0.051591903,0.033315625,0.034933552,-0.061881177,-0.013708346,-0.011974637,0.09529982,-0.064440414,-0.07015045,-0.04108585,-0.044371393,-0.09602519,-0.0065516387,-0.039089743,-0.030768752,0.01893801,-0.01311452,2.0810803e-33,0.010495537,0.05059282,-0.008538921,-0.010969521,0.0047892197,-0.058035713,-0.07452409,0.029285178,0.06651214,-0.09435821,-0.08026547,-0.04261071,-0.03171697,-0.0056833127,-0.021009013,0.05847472,-0.0011925095,-0.019595452,0.018504005,0.067560054,0.04620814,-0.020416442,-0.019989345,-0.023512777,-0.022076482,0.013165794,0.0061822813,0.018694175,0.0060310466,0.0026025556,0.016309734,-0.07359961,-0.06389346,0.007118168,0.07235265,-0.023515701,-0.004496637,-0.021400012,-0.016983083,0.067288704,-0.08629651,0.07098166,-0.013228049,-0.057219602,0.037783142,0.029129246,-0.0010305693,0.07985092,0.031988997,-0.0032796732,0.04076224,-0.049595527,0.092486694,-0.021447018,0.015682591,-0.017961176,-0.0445007,-0.06988057,0.059155863,0.023464128,0.047247384,0.014132219,-0.022033976,0.034148887,0.0020956318,0.0052621765,-0.13253802,0.013122545,0.048770294,-0.020038186,-0.047171887,-0.014082915,-0.007725875,-0.025174882,-0.03407104,0.037533697,-0.067164235,-0.033952024,-0.013207311,0.07277079,-0.0056122406,-0.057979945,0.09218257,-0.064088054,-0.0087905405,0.02564226,-0.008756783,0.040285237,0.011683796,-0.061789416,0.07768229,-0.07505043,-0.007766187,0.018130692,0.009903329,-3.0147744e-33,0.12136838,-0.058467157,0.025493577,-0.059165005,0.020045055,0.09209275,-0.025158271,0.03822538,0.0071035856,0.015415053,0.020133756,0.07738936,-0.03688772,-0.02453135,0.028299231,-0.019069381,0.016937157,0.08480477,-0.041717798,0.003725376,-0.024824316,0.049968906,0.022864621,0.007978272,0.013157644,-0.013095282,-0.023971412,-0.024204139,-0.031092195,0.075266056,0.03988502,0.069912136,0.032642014,0.0022389726,-0.011436103,0.06673881,-0.028138649,-0.030221188,-0.043498702,0.0047981655,-0.0019175599,-0.0031057189,-0.06396708,0.012159188,-0.015866095,-0.031633027,-0.043751776,-0.08022702,0.013972379,-0.03469008,0.037402596,0.02698221,-0.03494356,0.021297272,0.03796081,0.022407625,-0.022727005,0.007829082,0.0015191385,-0.059905913,-0.045705926,-0.06725247,0.021713562,-0.04557925,-0.018236594,0.12341188,0.0005589258,0.09752668,0.08173433,-0.021001711,0.022616234,0.08131313,0.020792011,0.023178076,0.019631289,0.06711709,-0.011691745,-0.03476756,-0.02251549,0.060062844,-0.041668728,-0.06575401,-0.060717687,-0.039844442,-0.06940912,-0.074881405,-0.006176791,0.021261942,-0.09320651,0.017344616,-0.05067629,-0.027120054,-0.009106015,0.08816992,0.09175348,-2.2605537e-08,-7.7178156e-05,0.026595078,0.052782338,0.055877395,0.09173467,0.041449066,0.011614671,0.023511907,0.039054148,-0.04204826,-0.00825729,0.023385443,0.07310489,0.03680115,0.025601478,0.10120688,-0.02613054,-0.03200603,0.0193729,0.06900206,-0.025561778,0.0017247114,-0.021952575,0.061722726,0.037522767,-0.08875459,0.06197579,-0.006341951,-0.017425656,0.037152126,0.025249628,-0.0040278058,-0.040008016,-0.048674542,0.0007447241,0.00881984,0.015227113,-0.03436226,-0.038710717,0.067871116,-0.009631613,0.03577031,-0.13910693,0.02816758,0.026271112,0.07137449,-0.0174892,0.056733742,-0.03504981,0.034626916,0.08212187,-0.000784058,-0.008607736,0.047443934,-0.07703343,0.018802969,-0.013924857,-0.039358553,-0.09495045,-0.003656995,0.05259299,0.021029862,0.16227236,-0.0268956 +1.1.1.222,"Also acts, more slowly, on (R)-3-phenyllactate, (R)-3-(indol-3-yl)lactate and (R)-lactate.",384,1.0,0.032728508,-0.22203599,-0.03299825,0.027469808,0.0138681615,0.09771535,-0.01192825,0.023462435,0.056700904,0.017599696,0.046081144,-0.02386392,-0.09143605,0.1138795,0.036399253,-0.03237527,-0.064280346,0.04296831,-0.020406282,-0.0060167275,0.10605783,0.027823852,0.06397733,0.031032408,0.055821054,0.03196959,0.059713375,-0.007341446,0.04022371,-0.09138063,0.0017725049,-0.033063907,0.05572316,-0.024663037,-0.017865134,0.054975886,-0.04098561,-0.046624333,0.07720773,-0.021506695,0.031190317,-0.042989265,0.05413647,0.022413196,0.006349432,0.044723365,0.002307185,-0.0033805885,0.009298806,-0.05063068,-0.08920955,-0.09246301,-0.034732357,0.06342022,-0.010936444,0.045407377,-0.09108475,0.011477254,0.014189981,-0.023280803,-0.015863646,0.010827329,-0.0030864822,0.07434019,-0.019825863,0.0063342853,0.05512382,-0.027866261,-0.006927834,0.050074138,-0.06496484,0.0018564647,-0.002385856,-0.06719021,0.025595017,-0.0021902607,0.018135563,-0.076635115,-0.013706386,-0.0281802,-0.023035415,0.017813493,-0.028630853,0.053046685,-0.068558745,-0.020060888,0.06676724,-0.061927047,-0.043933447,-0.0393982,0.034899816,0.07152813,-0.085546546,-0.02066681,-0.07130338,0.008192745,0.007093358,0.008549766,0.044177864,-0.027095262,-0.03610417,0.008200258,-0.010551931,-0.027217707,-0.08663622,0.02483391,-0.045629106,-0.026037442,-0.0037490884,0.06828184,-0.061999492,-0.004976063,-0.00090820895,0.08999799,-0.07777221,0.07261249,0.023875244,-0.02021505,-0.033110686,-0.0076987385,-0.047536,-0.067726746,0.070136815,-0.0010818975,-0.095996566,0.0025306565,-0.01966294,-1.3783245e-33,0.066636726,-0.057041682,0.017321397,-0.023082012,0.0408444,0.00045841158,-0.08690783,-0.006233033,-0.009217773,-0.037128907,-0.038461607,-0.050972432,0.045294315,0.02432044,-0.034946155,-0.004033037,-0.066842005,-0.016409256,-0.000104249455,0.00831986,-0.02580132,0.10391651,0.00013975406,0.014986077,0.0062074964,-0.05613225,0.051937114,0.049328268,-0.020299342,-0.039741386,0.08513935,-0.092127904,-0.070549466,0.06553475,0.009896229,0.05400764,-0.039407887,-0.06717422,0.025377244,0.012508491,0.025199253,-0.006566841,-0.023622734,0.021267187,0.0010991719,-0.022018585,-0.030694986,0.07528602,-0.025741512,0.07735022,0.08366722,-0.021084648,0.030509586,-0.04065444,-0.011757431,-0.014208064,-0.046477396,0.06304881,0.025379535,0.035393536,-0.022048011,-0.009794108,0.053313486,0.009832711,0.012652661,0.074549645,-0.123779245,-0.07662135,0.025817413,0.0075449855,-0.018454509,-0.07406061,0.039561857,0.044747982,0.06281307,-0.0014403844,-0.0399127,-0.057691865,-0.019233137,0.034714475,-0.07868499,-0.048215706,-0.015560883,0.06748513,-0.07634498,-0.036250178,-0.03567256,-0.046634655,0.06296438,0.038358696,0.028167414,-0.08784705,-0.025055412,0.04547028,0.033305593,-3.9428767e-34,0.052509736,-0.11277343,0.014269364,0.041837007,-0.012707293,-0.016418176,0.041380208,0.061605014,0.040537465,-0.054812323,0.10572915,-0.008808436,-0.027939903,0.027112959,0.01559417,0.028221587,0.10641068,0.05884042,0.02597157,0.042178847,0.028222254,0.13872448,-0.04065637,0.07657545,0.0481522,0.087751225,-0.044526085,-0.008178373,-0.06222537,0.05740621,0.04016186,-0.01905356,-0.050142348,-0.059584428,-0.04346665,0.040226392,-0.0056209685,-0.049607135,-0.08306499,0.01947872,0.009619094,0.05846317,0.10236354,0.021527532,0.054051947,0.02861161,0.0014911795,-0.016882358,-0.05170544,0.032776114,-0.028002424,-0.008426124,0.007333087,-0.0077700056,0.08686801,0.08948916,0.010063843,-0.058918938,0.013942423,-0.052001823,-0.062545605,-0.04286521,0.051010218,-0.106250905,0.04706272,-0.0087468345,-0.01963032,-0.0481016,0.17164856,-0.060178123,0.07051779,0.039299402,-0.011781018,0.072945945,-0.0820182,-0.063449286,-0.012249692,-0.05530345,-0.04149986,-0.03372972,-0.00928862,0.03161871,-0.00475224,-0.03040408,-0.057686258,0.01438861,-0.045323163,0.016960116,0.03012906,0.027605886,0.0010095229,-0.00012071006,-0.043358035,0.06533634,0.08168045,-2.9444575e-08,0.06777251,-0.07107957,0.047293875,-0.038135,0.0072617084,-0.008574496,0.05610047,0.03719053,0.0053667584,-0.07248353,0.030171964,0.10062873,0.037775006,-9.2752496e-05,0.03893323,0.008126473,-0.02904485,0.029710352,-0.0589993,-0.048188683,-0.08295097,-0.050804242,-0.07553859,0.050622836,0.027310135,-0.062093858,0.06295885,0.083923265,-0.06053937,-0.10221748,0.08649993,0.07023374,0.07850034,-0.017152982,-0.036586616,0.011571137,0.016035004,0.019119281,-0.05365448,0.06024869,-0.035145745,-0.010953386,-0.023850491,0.023377592,-0.009256097,-0.03401846,-0.028297776,-0.018495932,0.031668693,-0.102355234,0.013427807,0.011916461,-0.06317184,0.035092197,-0.08396353,-0.00057177944,-0.03267072,0.0046985312,0.03014424,-0.032803126,0.00030380147,-0.0126850335,0.12850676,-0.03584808 +1.1.1.223,"Acts on (-)-trans-isopiperitenol, (+)-trans-piperitenol and (+)-trans-pulegol. Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves.",384,1.0,0.0042475807,-0.113097906,-0.0881669,0.04253429,0.003928815,0.13486579,-0.032947984,0.02845328,0.016825145,-0.036572028,0.08469699,-0.035362992,-0.010828943,-0.041693732,-0.070912376,-0.015603601,-0.1000512,0.03673866,0.0023664113,-0.08128346,0.044728898,-0.051164325,-0.041162197,-0.07251294,0.01861837,0.070712216,-0.09054934,-0.016009223,0.08603712,-0.101050474,0.001499823,0.037620712,0.06622737,-0.09115302,-0.011785399,0.039241448,-0.00011695155,-0.031026892,0.123339005,-0.028114457,0.07391692,-0.020236228,0.004889463,0.00047930138,-0.035403334,0.014477342,0.014008179,-0.029783167,0.0032968053,-0.0108490195,0.019235449,0.047763944,-0.024870504,0.0728334,-0.012127386,0.0024109485,0.052137244,-0.0072849165,0.01541336,0.014247428,0.023306608,-0.019430742,-0.027746927,0.021440087,-0.041208282,-0.011122006,-0.0787115,-0.005858612,0.07110557,-0.010895696,-0.0066998717,-0.08517956,-0.11389616,-0.012772424,-0.053150587,0.029638184,-0.036317863,-0.009066637,-0.10363115,0.023876008,-0.0029475053,0.05714464,0.01168606,0.09029144,-0.008410784,0.039066084,-0.041781507,0.0014418566,0.0011815737,0.11329154,-0.03720695,-0.046048086,0.0014910011,0.015284664,-0.07359893,0.04560498,0.045234427,0.02369428,-0.05826534,-0.029806532,0.013906743,0.01697449,-0.14059459,-0.07999343,-0.052565794,-0.009571155,-0.046125952,-0.05744153,0.010242622,-0.02199959,-0.031585358,-0.026758479,-0.06541831,-0.045500897,-0.0350801,-0.0119307395,0.04565868,-0.02877826,-0.07493721,-0.019719003,0.0063073677,0.035611946,-0.010318767,-0.0014369577,-0.007996011,-0.041646674,-0.017896693,2.601176e-34,0.00014150304,0.022017842,-0.013507702,-0.03921667,9.6014715e-05,-0.0123346085,0.0034823753,0.052196447,0.06476798,-0.0583686,-0.02079675,-0.04209971,-0.07609927,-0.01955513,-0.07846566,-0.014170244,0.026996184,-0.047319364,0.07820594,-0.06871164,-0.043382566,0.09461601,-0.09982612,-0.018807756,-0.012717626,0.020724377,0.04990744,-0.041803904,0.049500067,-0.0091947755,-0.032751832,-0.019154321,0.006369751,0.05168631,0.076277696,0.004536314,0.01708073,-0.009501761,-0.03662921,0.021244846,-0.020257115,0.034166977,-0.13159451,0.02182251,0.06772879,0.0072471444,-0.06812789,0.0645692,0.111788325,0.036808655,0.009068881,0.012407935,0.12949714,0.010009893,-0.014200047,0.040080775,-0.021237016,0.065606855,0.008286888,0.06248351,-0.0039442014,0.00041594668,0.025065996,0.0053954488,0.05026945,0.09290049,-0.10767315,-0.07990831,0.059224363,0.06124801,-0.09341736,0.024348874,0.003679692,0.040618997,0.1122843,0.026878303,-0.039648417,0.048129573,0.10763948,0.005480096,-0.0691902,0.0396744,0.03145865,-0.02872164,-0.011937253,-0.023731165,-0.009665129,-0.039827656,0.009966841,0.04894847,0.013652185,0.02565011,-0.015706858,0.10526264,0.023897856,-2.3774989e-33,0.0039049936,-0.055896662,-0.012278285,0.0070076054,-0.06811714,0.04553502,-0.12885098,-0.001394439,-0.0010904955,0.091736086,-0.034366902,-0.00011608328,-0.025024742,-0.02149522,-0.024773361,-0.038214758,0.07345113,0.105571985,-0.042207822,0.019205188,-0.07672404,0.07762224,-0.018196084,0.047022678,0.0023835436,0.03564048,0.06842901,-0.01573641,0.037537266,0.06646381,0.10776324,-0.045316745,-0.056603685,-0.011488854,0.004289027,0.074266374,-0.035854615,0.12061053,0.010024216,0.037722766,-0.0427603,-0.010991723,0.07366089,0.0106964465,0.10767286,-0.028701374,-0.12120422,0.031811595,-0.025280721,-0.034421176,0.018374946,0.007040013,-0.052282292,0.014818056,0.06108272,-0.020084307,-0.0061120945,-0.033120867,0.07216484,-0.10695558,-0.05117549,-0.0060499506,-0.06460814,-0.020511366,0.029981758,-0.033654,0.017339844,-0.032990012,0.048576392,0.01375708,0.07542294,0.010556169,0.06589414,0.04290588,0.029976906,-0.018839141,0.032014582,-0.09457847,-0.010589005,-0.03413211,-0.08054901,0.0732553,-0.018269325,-0.09674918,-0.100293376,-0.02623566,0.01729602,0.081213385,-0.0023432476,0.044463668,0.020178236,0.08731028,-0.11244922,0.025448253,0.08094509,-3.262042e-08,0.046479434,-0.037176386,-0.014002171,0.05704668,-0.016967835,-0.024447436,-0.05694089,-0.039803687,0.067523964,-0.012739365,0.04432554,0.0075946664,0.03984579,0.005569556,0.03235348,0.016470205,0.057292685,-0.0003463441,-0.004514525,0.04707013,-0.064424485,-0.040152825,-0.009868987,-0.03425615,-0.018021302,-0.1150079,0.0227106,-0.022258487,-0.031291395,0.023968047,0.09480807,0.04436196,-0.035542045,-0.01663135,-0.0099048475,0.033975195,0.03610909,-0.023900663,0.03882543,-0.014308531,-0.03616498,-0.07414404,-0.01627466,0.049689412,-0.038714007,-0.013024889,-0.0006048661,0.00836634,-0.0069205556,0.03421554,0.020934582,-0.05256229,0.054277785,-0.07056896,-0.053552,0.056627687,0.051983107,0.010963665,-0.020405123,-0.06157302,-0.03758386,0.025402598,0.08709335,0.054695677 +1.1.1.224,Involved in the biosynthesis of mannitol in celery (Apium graveolens) leaves.,384,0.99999994,0.005418354,0.00948388,-0.05508725,-0.032600123,0.028436802,0.07468203,-0.08394216,0.017987402,0.06795325,0.10379572,0.09206954,-0.085932635,-0.0058154836,-0.064110175,-0.0043469076,-0.0057966113,-0.057447318,0.06863878,-0.06661441,-0.08671154,0.09802448,0.048585366,0.016209489,-0.013117081,-0.037188005,-0.08704774,-0.04898915,-0.04861831,0.0013361297,-0.13919702,-0.0054205433,-0.018021882,-0.043065775,-0.06344629,0.044027686,0.05905534,0.037886757,-0.12066803,0.1574227,-0.08013097,0.048246898,-0.051496893,-0.04741449,-0.068008445,-0.052719783,0.0015518636,-0.08362892,0.050792597,0.06444757,-0.012049772,-0.029179586,-0.0013672325,-0.027054466,-0.026969139,-0.05358269,0.0062414506,0.04326448,-0.021112159,0.042284183,-0.03015632,0.026764348,-0.014928647,0.05141323,-0.041961372,-0.066767596,-0.04727044,-0.05941593,-0.09205743,0.057871334,-0.0031169243,-0.025696395,-0.120660245,0.016720012,0.07305804,-0.08132931,0.039926164,0.019296559,-0.022139302,-0.06862982,0.0067708027,-0.0035469492,0.026808916,0.019012732,0.034381784,-0.043410227,0.03111393,0.002705201,0.018865673,0.09367457,0.03076069,0.05066776,-0.06964387,0.026137175,0.034642298,-0.029000066,0.012492032,0.05870487,0.021779057,0.0099816015,-0.058365572,0.024882775,-0.010177845,-0.019115299,-0.08346194,-0.022596242,-0.009749253,-0.0013690838,-0.06735767,-0.017795762,-0.043798372,0.020791432,-0.0033464225,-0.040095456,-0.0015783774,-0.10864247,0.027496334,0.04564209,-0.049126577,-0.0057555297,-0.020069316,0.07108789,0.020048289,0.03458625,0.039594263,-0.015638987,-0.057774648,-0.027751682,-1.8690489e-33,0.01427034,-0.0232792,0.049582835,-0.0057550897,0.12264204,-0.036214225,-0.024148066,0.023725657,-0.016010312,-0.065214604,-0.16915064,-0.076485135,-0.040263556,-0.016799001,-0.103191786,0.0600812,-0.09346651,-0.03567291,-0.008506519,0.009577459,-0.031929266,0.060137313,-0.018886754,0.05214348,0.01974776,0.064987525,-0.039961997,-0.023019478,-0.041527778,-0.0027412847,0.0417027,-0.071157895,0.0018927719,0.018012699,0.06324071,0.058028422,0.04845886,0.008492679,-0.026888795,0.052072305,0.004060952,0.031163786,-0.016573446,-0.0069738273,0.011380154,0.019082952,-0.0012329685,0.046492625,0.03606494,0.0056919274,0.082198896,-0.035044532,0.056726586,0.082821146,-0.015519357,0.024421645,-0.004527971,-0.054610286,0.04842948,0.095642224,0.0043758764,-0.012661195,-0.0053042118,-0.046029806,0.023336122,0.03639729,-0.054847512,0.08930599,0.008712738,0.0036195668,-0.04927109,-0.03986492,0.058035888,0.06713798,0.07743379,0.023339765,-0.015981682,0.010623847,-0.008791517,0.033791944,0.06553064,0.05442155,-0.053808477,-0.0336111,-0.014791944,0.01482155,-0.11093854,0.0017299806,0.0108414395,0.028181909,0.039077908,0.027752576,-0.099690266,0.023089582,-0.111310974,-1.5998985e-33,0.037449088,-0.05640044,0.025141327,0.05978351,-0.047232483,-0.0054319967,-0.041408457,-0.00024072845,0.0491912,0.035472065,-0.0008680545,-0.007671644,0.03432949,0.014260563,-0.043549813,0.044301998,0.010694262,0.13357869,-0.06588534,0.032697763,-0.09557855,0.09484076,-0.02717882,-0.07711892,0.029620204,0.03763167,-0.051816255,0.07524012,-0.02359543,0.08834781,0.03874457,-0.03505593,-0.012170101,-0.08776312,0.042541828,-0.03362439,-0.052154224,0.083742075,0.060802694,0.06626064,-0.12196173,-0.011253692,0.043624062,0.00029684097,0.1225073,-0.018932503,-0.041191872,-0.009137362,-0.090209685,0.04949056,0.054156035,-0.04825479,0.037348013,0.030038908,-0.011202823,0.016264822,-0.034373686,0.06893861,0.06871563,0.06807674,0.0069255945,-0.068218954,0.047031473,0.00045914203,0.017834585,0.06309653,-0.08955391,0.046006177,0.033217974,0.03939542,0.041824285,-0.0029159763,0.016487272,0.023594586,-0.010205504,0.026373465,-0.13085604,-0.058489952,-0.048553474,-0.011051561,-0.12050973,0.0024860185,0.046771828,-0.11918736,-0.033431794,0.06177078,0.046209708,0.024805075,-0.0016064979,0.020080408,-0.0657147,0.004215854,-0.04194499,0.040399704,0.072116286,-2.3068953e-08,0.0066108895,0.009987238,-0.01831521,0.01891278,0.05455214,0.026349196,-0.028972074,-0.01538062,0.05824587,0.016349364,-0.019680236,0.051712055,-0.011556218,0.0044479296,0.013497228,0.04159812,0.033474177,0.043539926,0.025733123,-0.012821454,-0.06544126,0.051421553,0.006747139,-0.052600693,0.057439957,-0.018634964,0.072482,0.011033842,0.000564667,-0.0043960204,-0.010246193,0.026063714,-0.018153604,-0.08883617,-0.048455868,0.028155932,-0.034430034,-0.0881896,0.061383083,-0.020773636,-0.024681969,0.0034862047,0.014160476,0.0063428157,0.0049646166,0.016692523,0.034382273,0.036771342,-0.06338036,-0.026006859,0.009185424,-0.013205923,-0.031443622,-0.028761948,-0.08667546,-0.009131142,-0.012449977,-0.0047719376,-0.029077584,-0.026049796,-0.0206557,0.037051696,0.14113282,-0.00035195108 +1.1.1.225,Chlordecone is an organochlorine pesticide.,384,0.99999994,-0.010225864,0.06555305,-0.03983782,-0.031072963,0.01923032,-0.024307895,0.05237506,0.06514601,-0.027281187,-0.049036913,-0.018954987,-0.09328,0.029801704,0.016774455,-0.06437643,0.061369002,0.0004261021,0.012929271,0.004109956,-0.007085094,-0.023592962,0.056858145,0.009450142,0.004773156,-0.10231924,0.069806375,-0.0050949454,-0.010110499,-0.0038620888,-0.019442905,0.03777619,0.050696336,0.026626317,0.0015473147,0.02350991,0.04801497,-0.033731624,-0.040262066,0.02674276,0.07287066,-0.03236667,0.03800044,-0.047283318,0.0052725803,-0.1000018,0.0400408,-0.07173118,0.06799895,-0.018097796,0.018617226,0.058484986,-0.027032588,0.0010911968,0.020343754,-0.039958607,0.0032672412,-0.0579486,0.005667689,0.02997226,-0.034132447,-0.008505216,-0.043005634,0.0084182015,0.006491027,-0.00255819,-0.0075643156,-0.011163061,-0.03669613,0.047466952,-0.0959148,0.09075969,-0.07500351,0.013366996,0.038594816,-0.008207602,-0.022043705,0.076740846,-0.09047938,-0.020301998,-0.054082222,-0.017334102,-0.027987242,0.0716421,0.022776188,0.09648218,-0.0064494326,0.019400176,0.013171058,0.025877753,0.08832636,0.043673962,0.048553433,0.009275533,-0.050624367,-0.068023264,0.07945782,-0.056688193,-0.0031135082,-0.11238849,0.02503227,0.011631063,0.011174881,-0.18542042,-0.067205966,-0.014158636,-0.042770263,0.07571481,0.054085683,-0.07134429,-0.08022347,-0.0400693,0.039060898,-0.007829196,-0.01826102,0.03800514,0.036030587,0.081113614,-0.032652836,-0.022079071,0.0035274788,-0.016675841,1.9706358e-05,-0.07877057,0.0018173832,0.014161298,0.08131462,0.004451713,-7.2642493e-34,-0.007084635,0.041988246,0.039464295,-0.006676619,-0.015258572,0.009500279,-0.06657019,0.030270532,0.015605734,-0.13220501,0.024344156,-0.116568714,-0.083188,-0.053316563,0.03126986,-0.037214518,-0.030939965,0.058925223,0.06554878,-0.05783574,-0.058236625,0.05204425,-0.03744061,0.025743295,0.009384869,0.03316161,-0.057876848,0.0073076654,0.10375325,0.01882347,0.022300623,-0.028603211,-0.049649272,-0.013032592,-0.07139036,0.06797763,-0.07427694,-0.041258506,-0.10523278,0.0016816638,-0.07579434,-0.027930846,-0.05290598,0.026938852,0.009233977,-0.09652883,-0.082234785,0.015834402,0.031831793,0.01113376,-0.026395578,0.011550217,0.12286198,-0.024974922,-0.02790589,0.052403186,0.031221932,-0.074322835,0.015624079,0.03885855,0.067136705,0.12482637,-0.075093426,0.04610617,0.06319086,-0.032093666,0.020613018,-0.010831759,-0.03988331,0.034615554,-0.029045122,-0.0741695,0.043888222,0.07708145,0.056964688,-0.001662086,-0.022971665,-0.053139843,-0.0391969,-0.0037330976,0.0068640914,-0.00042155496,0.09758389,-0.035751723,-0.04830021,-0.022839364,0.010809912,-0.05262568,0.032192376,0.013997056,0.057156824,-0.031764142,-0.004705871,0.013432783,-0.1229588,-7.25598e-34,-0.052523974,-0.077090435,0.010571234,-0.04828907,-0.009222621,0.06705602,-0.11259296,-0.011170602,0.0026472637,-0.007440352,0.06949581,0.04091589,-0.040734824,-0.03743735,0.065403245,0.051596574,0.06355242,-0.034294914,-0.036369845,-0.023325915,-0.07594081,0.076675914,0.032650106,0.11384553,-0.06337682,0.017453182,0.014523105,0.071404405,0.15915258,0.018636689,0.007120784,0.013298967,-0.0139601715,-0.00130069,0.035741538,0.060041144,-0.04032329,-0.032364544,-0.013010419,0.028803682,-0.060715996,-0.0072042276,-0.03449981,0.060472425,-0.014238341,0.027248923,-0.02458171,-0.0036888153,-0.04655365,0.02535005,-0.049222242,0.10069129,0.014786625,-0.039310228,0.039381348,0.001075528,0.008590782,-0.06421341,0.07087477,-0.03633867,0.046252858,0.027254168,-0.09881668,0.09194039,-0.014719456,0.031005692,-0.037667453,0.07036395,0.015709596,-0.0050547943,0.03073274,0.0016341719,-0.026508948,-0.035479173,-0.071520805,-0.06627528,0.085704096,-0.0040566176,-0.004642154,-0.09797527,0.018299187,-0.0034234594,0.05398243,-0.018156378,-0.053694222,-0.10359957,-0.025141934,0.044483066,0.010701122,0.06530777,-0.066243716,0.012298341,-0.0013739755,0.08583696,0.048601788,-1.8172955e-08,0.05374848,-0.0316411,0.12155378,-0.054907087,0.04023405,-0.046928264,-0.0052204253,0.008999431,0.045941822,0.036486108,-0.059152093,0.057084866,0.0894396,-0.033423256,0.023153376,0.021714557,-0.00831833,-0.011164873,0.022409808,0.027757602,-0.10199968,0.047592115,-0.04579621,-0.102414005,0.005746591,0.04101945,0.03195224,0.011251932,-0.041492805,0.084285505,0.06762955,0.012510159,-0.008275609,-0.010643742,0.0061579114,0.053888243,0.019801328,-0.054612916,-0.03370358,-0.028450413,-0.03632245,0.03936167,-0.0040485095,0.058877356,0.047833566,0.0025820863,0.082962476,0.011933966,0.066016786,-0.019444738,-0.013016,-0.0060133776,0.009959234,-0.028552487,-0.030068675,-0.012040887,0.0060813595,-0.09274222,-0.0006262387,-0.08625678,-0.0074649546,0.024336396,0.14465022,0.054545134 +1.1.1.226,"The enzyme from Corynebacterium cyclohexanicum is highly specific for the trans-4-hydroxy derivative. cf. EC 1.1.1.438, cis-4-hydroxycyclohexanecarboxylate dehydrogenase.",384,1.0,-0.032618333,-0.021050911,-0.043879293,-0.010502617,-0.05444882,0.00393722,-0.08063831,0.058902256,0.016287187,-0.03079721,0.029878013,-0.07719469,-0.044290613,0.013763634,-0.021886379,0.0682205,-0.015008949,0.060300842,-0.017035095,-0.059629824,0.007003855,0.022798298,-0.011395816,0.046484068,0.024843559,-0.0409987,0.041033927,0.024280831,-0.023855146,-0.021269653,0.060382973,-0.011782024,-0.029196862,-0.03630344,0.061233226,0.052220512,-0.056119833,-0.12099657,0.16976151,0.025298549,0.06332043,0.06104575,-0.002732648,0.012309535,-0.0827975,0.039646994,-0.0023333752,0.008475528,0.06119755,-0.03639305,0.058672037,-0.05501436,-0.072619304,0.045218863,0.047868885,-0.0041913046,-0.061846677,-0.03145936,0.05940858,0.07680061,0.022749523,-0.015923433,0.03731569,0.03962019,-0.016442942,-0.0069764247,-0.026941836,-0.06267937,0.027946064,-0.08242933,-0.1008185,-0.047586896,0.05525149,0.08780872,-0.06974131,0.0072657685,-0.042070206,-0.026137343,0.008962186,-0.06724093,0.029649047,0.0016624659,0.004947889,-0.00071132224,0.03629729,-0.04245946,0.06363681,-0.03611449,0.020911494,0.055579767,0.07137899,0.015156418,0.018734256,-0.07505994,-0.007369936,0.02399737,0.049619664,0.018902857,0.05464224,-0.012928499,0.0014937102,0.06012843,-0.06594945,-0.047532767,-0.06611777,-0.039987378,0.044968758,0.07780409,-0.0045591625,0.0421372,-0.055695087,-0.038245127,0.016623471,-0.04399995,-0.045502122,0.015112441,0.049976997,-0.044260424,-0.02769034,0.010444059,-0.009177379,-0.06429538,0.058303498,0.032347217,-0.025014235,0.09035651,-0.055030994,2.4074448e-33,0.02680481,0.027129868,0.037030924,-0.0066341115,0.06072478,-0.0579846,-0.02355996,0.013941489,-0.059417844,-0.048435222,-0.13063288,0.0097434,0.023391623,-0.047298927,-0.07780326,0.0065785716,-0.036986765,-0.007239482,0.047747865,0.09323213,0.030607436,-0.019558247,-0.025655383,0.05963975,-0.08996419,0.02999031,0.0211058,0.021835478,0.09926265,0.0076343226,-0.13111147,-0.11011985,-0.0763243,-0.058227908,0.04679749,-0.02877979,-0.037989527,-0.05801398,0.022013178,0.08888252,-0.022041863,-0.032775197,0.018108802,-0.07553182,0.048992034,0.041703265,-0.033471823,0.04595273,-0.022085091,0.0027173671,0.00043536705,-0.0010709993,0.037049774,-0.075585894,-0.03304913,-0.029175783,-0.030448763,0.06516612,0.055428855,0.057931364,-0.009515144,0.10097619,-0.052341655,-0.01101874,0.029035231,-0.004891164,-0.06827954,-0.031924773,-0.053455725,0.038124762,-0.031464707,-0.032038484,0.074414924,-0.018199313,0.07702697,0.0032781467,-0.101420574,0.0023432197,0.023196496,-0.022070449,-0.081739366,0.041607544,0.0466326,-0.017619235,-0.019929182,-0.058725167,-0.02528108,0.029425424,-0.035373855,0.060694497,0.04718754,-0.082677156,-0.0405278,0.06405493,0.033522725,-3.787561e-33,0.09719435,-0.010770505,-0.012199414,-0.09954223,0.032227762,0.06020134,0.04236519,-0.016874552,0.062106464,0.057775903,0.17733772,0.033637002,-0.035286088,-0.039848324,-0.013591411,0.013509211,-0.019763106,0.052530885,-0.06146639,-0.017771663,0.019015927,0.059408654,0.005591725,0.04138443,0.025217988,-0.0052846307,0.034319215,0.10671952,0.029081188,0.08860443,-0.060054123,0.034507535,0.006946291,0.03870452,-0.082793966,0.07313678,-0.04003501,-0.0064444873,0.02435819,0.033954795,-0.017004391,-0.008187825,-0.012981778,0.09128477,0.027041228,0.017872486,-0.050185826,0.020903641,0.03974584,0.03096752,0.002289995,-0.014071063,0.007605492,-0.024903871,-0.056991577,0.062248465,-0.010180982,0.003426476,-0.016531471,-0.015517944,-0.052495174,-0.08516944,0.106929265,0.01372192,-0.04181892,0.07461767,-0.05221103,-0.00077221915,0.048961777,-0.02684315,0.03385079,-0.011833533,-0.069296114,-0.025487255,-0.038510237,0.0239603,0.039891146,-0.041970212,-0.079526514,0.008931965,-0.009683506,-0.012116345,-0.03126925,-0.022646025,0.015002037,-0.05369472,-0.027324397,0.08485712,-0.0112041645,0.011750095,-0.020820577,-0.018282974,-0.07896257,0.022593362,0.023096526,-3.359068e-08,-0.04978164,-0.035318464,0.03320574,-0.0039124065,0.071312554,0.07777872,-0.03534845,0.007207003,0.052445076,-0.092816114,0.026395341,0.029876348,-0.04089342,0.056186873,0.058565423,0.05889423,-0.091452174,0.0058084163,0.0059935567,0.0087321,-0.05148086,-0.048228614,-0.032322336,0.04359984,-0.034979314,-0.041646544,0.06433502,0.0030256333,-0.028619872,-0.006468598,0.06678715,0.026560588,-0.073774315,-0.0011453643,-0.01955159,0.0162352,-0.032734815,0.0332114,-0.04528003,0.080127835,0.0011762006,-0.039701253,-0.11411267,0.036916535,0.032958362,0.048108194,-0.051745545,0.05995422,-0.0029287722,0.040191114,0.06767054,-0.03336951,-0.06916234,0.004107699,-0.0025255885,-0.0034313293,-0.036993194,-0.0766883,-0.108409286,-0.059802003,0.020762216,0.008164885,0.25720352,-0.004020117 +1.1.1.227,"NADP+ can also act, but more slowly.",384,1.0,-0.053992137,-0.105439894,-0.01864176,-0.009106063,-0.00077834836,0.07565395,-0.046764635,0.046248246,0.04366526,0.027993914,0.02309399,0.048356857,-0.07073112,0.1173433,0.041363623,0.025087457,0.05568001,0.027636908,0.03745261,0.03902409,0.03295715,-0.02311679,0.07520235,-0.06870408,0.017507976,0.034424387,-0.08392694,0.023662042,0.063176595,-0.10595124,-0.014502133,0.045139324,-0.070539564,-0.048174646,-0.08208639,0.0874997,-0.07537328,-0.005541702,-0.016426783,-0.053086396,0.04850765,-0.030446313,-0.07350972,0.0166074,0.017861439,-0.066710025,-0.012710075,0.016198013,0.016167657,-0.028261373,-0.0814141,-0.03518136,0.019391524,-0.0034326012,0.058892876,-0.027389739,-0.05195994,0.011537591,0.00408795,-0.08087138,-0.041447602,-0.029898925,0.021182215,0.032484274,0.081184186,0.027791243,0.074965775,-0.006835019,-0.015634503,0.04877972,-0.07729771,0.03531266,-0.0033733028,0.03271925,0.010254013,-0.006711916,-0.080773376,-0.059176866,0.07412146,0.03189693,-0.0024026576,0.04822874,-0.10315478,0.009910858,0.017894927,0.04539013,-0.013408386,-0.028071608,-0.089250706,0.009139025,-0.015985956,0.0026588156,-0.04299734,0.06290631,-0.08498832,-0.021036517,-0.0050106235,0.008658482,-0.0758302,-0.01591862,0.011233859,0.10968947,-0.03466546,-0.012557304,-0.019723995,-0.033191446,0.021377176,0.013078935,-0.081317075,0.059545316,-0.042232204,-0.040859196,0.029290576,-0.00085322995,-0.022503478,0.116491474,-0.06293265,0.021480806,-0.08733713,-0.041264646,0.021750385,-0.032950595,-0.023460526,-0.012537466,0.011492291,0.018175274,-0.03375242,-1.7590843e-33,0.0836015,-0.037433635,-0.012330401,0.021884223,0.02740073,0.018148921,-0.04927342,0.036972865,-0.017758014,-0.031334836,-0.052974854,-0.14371257,0.04001801,0.0114379125,0.020071112,-0.019050442,-0.03733201,-0.030411871,-0.07507141,-0.0474787,0.064534284,0.08514022,-0.0029337197,-8.957065e-05,0.023892116,0.025630936,-0.03506582,0.07463895,-0.0036398156,-0.004954917,0.04571425,-0.051805433,-0.16549711,0.0525725,0.040307898,0.05495044,-0.0328677,-0.08826097,0.040419042,0.01588887,-0.12732148,0.075193375,-0.064871885,-0.009743349,-0.004579038,-0.08332702,-0.012508172,0.06040807,-0.05337187,0.048986796,0.08520252,0.015224105,0.0740225,-0.038111616,0.02290255,0.08306533,0.04616853,0.00033445065,-0.07515445,0.13910742,0.063858666,-0.023714038,-0.0060284147,0.058438964,-0.08488984,0.044318177,-0.11108663,-0.044450477,0.05226782,0.00520261,0.060969032,0.034844365,0.04748394,-0.04127276,0.056402165,-0.09519969,0.059267137,-0.064809054,0.014920457,0.014001876,-0.0013329142,-0.08854652,-0.04192058,-0.0042114253,-0.009783584,0.006222436,0.04928761,-0.07130364,-0.01761477,0.03678526,0.005006887,-0.018064722,-0.0008303699,-0.034138255,0.026976852,2.9520862e-34,0.059258033,-0.03359154,0.051645085,0.018049955,0.021074966,0.083535984,0.019906064,-0.0272716,0.0038431482,-0.054446004,0.045245834,0.051824052,-0.014569614,0.0016204698,0.027245203,0.014557378,0.029319275,-0.0012884202,0.023632634,0.01763384,0.008779683,0.13589373,0.040215086,0.015625928,0.0027035954,-0.018376887,-0.028435752,0.02657386,0.006481477,0.026264895,0.0024986418,0.028592627,-0.16071601,-0.04727065,0.030168535,0.07267919,-0.046570178,0.014519584,-0.06642263,-0.021398043,0.04264731,0.0025308675,-0.007047142,0.057877537,0.03988574,0.022922484,-0.00040331858,-0.045100648,-0.008009211,0.053470116,0.017210824,0.045836557,-0.070839584,0.02565326,0.06497449,0.0084097795,-0.00012199629,-0.025803166,0.009786255,-0.01591895,-0.0017260272,-0.033367712,-0.023472035,-0.035425127,0.13653968,0.041765783,-0.0042363578,-0.014336332,0.1269283,-0.053198427,0.07409816,0.012885679,-0.020037845,0.03445568,-0.022039179,-0.061800428,-0.060088284,-0.017750368,-0.012565085,-0.11004151,-0.045088325,0.018729802,-0.013728986,-0.08846276,-0.06747314,0.067244776,-0.015532202,-0.009637356,-0.008447149,0.053709976,0.038417276,0.08085371,0.06146499,0.01830158,-0.02769033,-1.8711123e-08,0.019091269,-0.004823615,0.044008717,-0.04106396,0.020009272,0.047054313,-0.0023039451,-0.032945074,0.00020943786,0.042502064,0.08327548,0.12807308,0.1116748,-0.0020704975,0.086939156,-0.02141404,-0.04125895,-0.0051088147,-0.047821596,-0.010107712,-0.060117234,0.017608061,-0.04379593,0.047316276,-0.041492738,-0.019679066,-0.020873459,-0.0038509618,0.071257085,-0.09114454,0.03390865,-0.00073187135,0.043669973,-0.0020362183,-0.02110987,0.0774485,0.03745717,0.054519728,-0.03682305,0.097156644,-0.071463384,-0.0813822,-0.0016031318,0.036002763,-0.049728405,-0.007067964,0.030291414,-0.11113641,0.005308863,-0.05265698,0.096433885,0.022971477,-0.010667136,-0.041644767,-0.0302403,0.075865045,-0.030773629,-0.023823692,0.030419001,0.0041237157,0.021255625,-0.06390395,0.0204287,0.026062455 +1.1.1.228,"NADP+ can also act, but more slowly. Involved in the biosynthesis of (+)-3-thujone and (-)-3-isothujone.",384,0.99999994,-0.07691168,-0.086284645,-0.055805106,-0.010990657,0.04307361,0.07503197,-0.088276885,0.044646937,0.059121303,0.024951015,0.0508251,0.02460188,-0.083296575,0.044279866,0.027636653,0.023160975,-0.021091014,0.05075244,0.027397135,-0.0359454,0.01335576,-0.042690516,0.014639999,-0.06908403,0.089785285,0.036464166,-0.045907144,0.0215616,0.05846549,-0.050748073,-0.08203048,-0.0007663158,-0.0008499075,-0.055592153,-0.035528615,0.09185549,-0.108671136,-0.00490407,-0.00082709,-0.02896959,0.041966647,-0.06358946,-0.08966175,0.022239748,0.004960853,-0.074153215,-0.027435388,0.030315455,0.0492907,-0.015749836,-0.048343528,0.021251598,-0.02682893,0.044188496,0.0042373585,-0.06692758,0.0013470406,0.03422902,-0.030561268,-0.062097095,-0.01308405,-0.076190524,-0.002019578,-0.010144089,0.100838445,-0.02495675,0.051077526,0.040941343,0.00620088,0.054989446,-0.009762347,0.026766099,-0.006869153,0.037807617,-0.012516703,0.028465498,-0.09316905,-0.029423434,0.0101257935,-0.0028464252,0.04698948,0.076374836,0.0003271934,0.06149344,0.0168265,0.014941365,-0.06261128,-0.00754035,-0.05748768,0.05472126,-0.0124544995,0.023129014,-0.078623004,0.028622465,-0.06630069,0.022919402,0.025887143,-0.021428525,-0.0497474,-0.034805074,0.008776025,0.1219324,-0.09555126,-0.089397885,-0.0015028722,0.03914956,-0.033144955,-0.00020485245,-0.114548065,0.06869096,-0.02481485,-0.0806134,0.027505372,-0.014171445,-0.0583417,0.12431545,0.014967377,-0.019330584,-0.072632,-0.03881421,0.019536972,0.017611032,-0.00068124966,0.015813332,-0.02063793,0.00039282214,-0.027012905,-5.2602835e-34,0.08419549,0.00088206754,-0.07572941,0.019785581,0.01561031,0.052689184,-0.09000137,0.065669596,-0.05550049,0.008601711,-0.07644781,-0.16253343,0.03666724,-0.044078346,0.0024585798,-0.009902061,-0.007883599,-0.04543323,0.0123055335,-0.042038996,0.01823394,0.045695923,-0.045279957,0.013869163,-0.005931962,0.05248445,-0.0028749802,0.068629675,-0.011774446,-0.014162689,0.027015572,-0.07083914,-0.12032583,0.015852809,0.10283873,0.017782548,-0.016413245,-0.06230872,-0.033745147,0.019560562,-0.10546235,0.066620395,-0.051082704,-0.02992128,0.059553433,-0.040487435,-0.0053759306,0.04665667,0.024454456,0.06595881,0.04673544,-0.03204895,0.10353898,-0.058783956,-0.043541364,0.045712613,0.018765302,0.018111084,-0.042710703,0.08247578,0.010863028,-0.027971849,-0.0075681573,0.0737033,-0.09011847,0.053728316,-0.1425682,-0.030509125,0.046320926,0.038638245,0.028633576,0.0006771323,0.03057518,-0.0187866,0.086831324,-0.055305384,5.965862e-05,-0.0147429025,0.020030297,0.016638402,-0.032817908,-0.029998709,-0.01968294,0.011845072,-0.021663468,0.039570116,0.031952802,-0.05043924,0.013143405,0.027516892,0.057656515,-0.022042591,-0.013018068,0.0021178604,0.049578086,-1.6669e-33,0.047285676,-0.059748895,0.050728787,-0.09118021,-0.011048683,0.12976833,-0.062282544,-0.03968986,-0.054040328,-0.046287578,0.065788984,0.004620482,-0.05123541,0.0064667063,0.009036612,0.008781193,0.004141472,0.030385373,-0.01095968,0.0061703264,-0.01675486,0.09645937,0.002832245,0.030368676,0.009970722,-0.007628136,-0.028679525,0.041079756,0.03952724,0.12142845,-0.0032691224,0.007790521,-0.13721566,0.020624898,0.06299135,0.10247065,-0.04581505,0.04312304,-0.013240135,0.015086527,0.01955431,-0.020351795,0.0192109,0.05301057,0.065333985,0.010633694,-0.043878138,-0.025676878,-0.038478628,-0.056815043,0.059778403,0.035665143,-0.044514246,0.062631294,0.110428326,0.037948567,-0.0021345804,-0.04165962,0.050121985,-0.0032942072,-0.040888328,-0.09577711,0.022255136,-0.040473785,0.095213786,0.036244925,-0.009932084,0.030408295,0.09534086,-0.033819105,0.09528674,0.06141017,-0.02016846,0.0398782,-0.02273255,-0.11657357,-0.027678061,-0.007681973,-0.04978261,-0.05011636,-0.026814664,0.013298187,-0.041039675,-0.08986497,-0.090222485,-0.008490666,0.012315143,0.07712086,-0.04361936,0.06803526,0.020303559,0.1246843,-0.005387901,0.023691315,-0.02158426,-3.1495784e-08,0.025669511,-0.038702693,0.06356306,-0.03507917,0.007564553,0.018474624,-0.004219684,0.024229867,-0.0035063564,0.032927983,0.033227433,0.13349794,0.07342267,0.00029325002,0.08277341,-0.026827978,0.006017983,0.009294372,-0.020966673,-0.039925374,-0.07493373,0.021053616,-0.094701014,-0.010161326,-0.032944873,-0.017384952,-0.01496663,-0.05173268,0.066634916,-0.0726141,0.06532487,0.035405096,0.011124145,0.0011197942,-0.061224435,0.061635915,0.019088045,-0.0020369515,-0.031894,0.0059761144,-0.06681851,-0.0638999,-0.06942187,0.049848527,0.003114985,-0.024243576,0.074666746,-0.08127215,-0.05400116,-0.034268737,0.056502517,-0.018924983,0.047051445,-0.038783092,-0.038324017,0.021181801,0.001476001,-0.030667609,-0.0074193934,0.019581448,0.003271249,-0.050652694,0.09750793,0.026315162 +1.1.1.229,"Also acts on diethyl (2S,3R)-2-methyl-3-hydroxysuccinate; and on the corresponding dimethyl esters.",384,1.0,-0.033797868,-0.07066108,-0.07359371,-0.046458814,0.044121932,0.07120956,-0.068648495,-0.02861786,0.06975486,-0.038022745,0.05654171,-0.07509513,-0.060506232,-0.04529183,0.0056247804,0.01873145,-0.044919144,0.013339,0.030851316,-0.02992046,0.085183986,0.0024317268,0.00051701796,0.045689877,0.0076070647,0.021952383,0.04956223,0.04327199,-0.018504847,-0.11041347,0.031843826,-0.0029184304,0.03608618,-0.039742,0.0006395848,0.043817256,0.003274467,-0.026467364,0.043844156,0.033489063,0.07629184,-0.0729571,0.02374719,-0.01122695,-0.047538575,-0.018283095,-0.03310308,0.03803013,-0.0055786376,-0.00014360635,-0.04302108,-0.08195282,-0.020106597,0.043684598,0.021842062,0.02397948,-0.0007904041,0.050526664,-0.025138218,0.05491278,0.015635788,-0.042494375,0.015170001,0.03350561,-0.005955393,-0.012254899,0.0021452059,-0.04888802,-0.007947086,-0.06488265,-0.049424265,-0.065717846,0.02558388,0.040604327,-0.036522154,0.035027783,-0.02422122,-0.056894932,-0.0016065327,-0.06483197,-0.060323097,-0.018431876,-0.010695113,0.10787585,0.0296884,-0.0275445,-0.04927963,-0.064677015,0.03727596,0.09721947,0.016078727,-0.042560227,-0.040519223,0.05456592,-0.12066065,0.057314828,0.037217002,-0.036679346,0.08828653,-0.031452347,-0.011358,0.035616055,-0.08007765,-0.07288886,-0.07009562,0.023088833,-0.026732175,0.027109776,0.014361803,0.036140077,-0.0070766443,0.012655103,0.007550645,0.0136773875,-0.12765123,0.040823378,0.09135244,-0.09441097,-0.030891728,-0.11142324,-0.020330407,-0.04195734,0.044141065,-0.004839449,-0.053590894,-0.0027449543,-0.057753026,-1.2816622e-33,0.010528836,-0.00278804,0.02591745,0.049530353,-0.014336996,-0.02068875,-0.0581862,0.014280943,-0.018101363,-0.043184597,-0.085124515,-0.045474906,0.05538755,0.038797375,-0.018416448,-0.05337385,0.007743341,-0.0029119744,0.03165555,-0.059342436,0.0056513115,0.105827026,-0.07933012,-0.022518989,0.004449331,-0.0180294,0.043678585,0.01116871,0.110816054,-0.015415583,0.098509446,-0.07357663,-0.07536912,0.043348495,0.063748434,0.041821245,-0.056284823,-0.019755159,0.029519217,0.06347863,0.057538852,-0.013666107,0.06673868,-0.018849818,0.016003512,0.009622355,-0.024853159,0.0618618,0.09617386,0.02851857,0.062227882,-0.05299952,0.11622833,0.003179893,-0.0037606729,0.07445551,-0.04307092,-0.011999724,-0.03240555,0.031443633,-0.083728015,0.049850088,-0.01581311,-0.052575372,-0.012692867,0.013617387,-0.09020611,-0.039668515,-0.04969438,-0.0032370877,-0.01668437,0.02250923,0.12096722,0.049440075,0.06580192,0.0044158758,-0.05041891,-0.004856027,0.0121492,0.07944199,0.03805169,-0.0089703025,0.08421324,0.027137766,-0.09228918,0.0034271067,-0.006417618,-0.054524217,0.012267593,0.06851134,0.08588732,-0.06267291,-0.039605323,0.03572357,-0.014144156,-1.6727472e-33,0.010644649,-0.08279196,0.06377324,-0.04780261,-0.021041246,0.004068193,-0.041642036,0.030267652,-0.013013463,-0.06441787,0.10396737,0.01622022,-0.045565642,-0.073877454,-0.030603556,0.006238069,0.024169993,0.09333668,-0.10117512,0.007785855,0.008132274,0.08485699,0.011954863,0.10513997,0.045369007,0.013522906,0.07870343,0.06346583,6.30361e-05,0.10178496,0.027827337,-0.07230905,-0.04442365,-0.016911188,0.054689508,-0.0027808433,-0.06556228,-0.047184695,-0.051399287,0.0051273634,-0.055204924,-0.0018024814,0.032491785,0.06985056,0.08230489,0.056019764,-0.06468163,0.013670428,-0.027073592,0.0048037367,-0.03255834,-0.047673687,0.0038632373,0.08197894,0.103995316,-0.0007939298,-0.019850645,-0.05706389,0.045956288,-0.040414903,0.016457237,-0.015836073,0.0150792,-0.08226288,0.010902013,0.017845582,-0.07450076,0.008771108,0.035609584,0.025756145,0.09979985,-0.0145196365,-0.018069375,0.008567703,-0.054105446,-0.10421217,-0.065655604,-0.08848438,-0.08698235,0.007959992,0.05693451,-0.023935579,0.017554192,-0.06761257,-0.04143191,-0.039079104,-0.003887376,0.04700073,-0.05992584,0.04728932,-0.025850985,0.055726234,-0.034241144,0.06859022,0.04219457,-3.4645414e-08,-0.0043926747,-0.07691473,0.081490815,-0.06346487,-0.06404292,0.036460448,0.040029537,0.012291929,0.0748188,-0.00055492186,-0.010216013,0.0767505,0.039214,-0.0057001477,0.057251833,-0.08498263,0.037767425,0.062044945,-0.062031236,-0.04025976,-0.10596754,-0.00224383,-0.082608566,-0.0058932067,0.066655606,-0.03147079,0.021251855,0.016572997,0.088603616,-0.011546854,0.061037544,0.02374489,0.014939532,-0.0065407064,-0.08072112,0.08194331,-0.045956865,-0.009999824,-0.028790655,0.047700647,0.030950278,-0.023299044,-0.04454707,0.06990513,-0.014985706,-0.0143733565,-0.043032583,0.081565596,-0.03898048,-0.007466774,0.02147635,-0.025323816,-0.015808295,-0.006576443,-0.11848987,-0.044743154,-0.03778257,-0.013058498,-0.009302252,-0.014075736,0.01978973,0.0030849683,0.16033198,0.043127235 +1.1.1.230,Highly specific to 3alpha-hydroxy derivatives of glycyrrhetinate and its analogues. Not identical to EC 1.1.1.50 3alpha-hydroxysteroid dehydrogenase (Si-specific).,384,1.0,-0.0378687,-0.045165345,-0.04262433,-0.050035045,-0.059341792,-0.04536986,-0.0657873,0.020315671,0.0051236604,-0.058603097,0.021777669,-0.015528061,-0.039671216,-0.01756321,-0.014652264,-0.046604536,0.0105267055,0.014781819,-0.019530877,-0.021467913,0.052798815,0.061598044,-0.0050784773,0.019357275,0.01635511,-0.021426013,0.032634955,0.08439347,-0.05108035,-0.08104519,0.047745693,-0.010826832,0.04643788,-0.06526759,0.015367213,0.08113919,-0.09325628,-0.018849522,0.053840626,0.09295314,0.05683279,-0.040433183,-0.03251298,-0.043679867,-0.003740487,-0.058858372,-0.04918028,0.048329707,-0.05697818,0.050281476,0.022369402,-0.065440364,0.014759675,0.06046718,0.061192725,-0.0879577,-0.06316464,0.09026934,0.05515793,0.07181111,-0.026320811,0.036954697,0.049686596,0.02717136,-0.021070836,-0.015307147,0.06967956,-0.14850117,0.040231686,0.0032111625,-0.0992438,-0.07901948,0.040723104,-0.0076315603,-0.06187517,0.03809217,-0.029536976,0.029727446,0.047882877,-0.039458655,0.008337599,-0.006625285,0.094806,0.06482482,0.011868463,0.011783241,-0.045581814,-0.008356427,-0.0176435,-0.032533284,0.03770815,-0.072046965,0.034400187,0.019897737,0.010564477,0.029346418,0.023739196,-0.046045434,-0.009292604,-0.042489763,-0.048846122,0.08957893,-0.064050235,0.022133764,-0.025041753,0.037671186,0.040111404,0.06540781,0.009988689,-0.011097119,-0.0557987,0.0026221308,0.031615805,-0.047970034,-0.067754015,0.07134181,0.029116714,-0.03319214,0.04978515,-0.06352937,0.022726573,-0.053727806,0.035319693,-0.033062026,0.019462256,0.07663589,-0.037354317,-1.7512077e-34,0.07500016,0.04428779,-0.0023761324,-0.09679113,0.02926648,-0.036135774,-0.04407505,0.040040508,-0.02895656,-0.019831402,-0.028239265,0.030555785,0.014726311,0.10134558,-0.019899571,0.06296041,-0.021316096,0.00615304,0.012882127,-0.0008707832,0.049526095,-0.02760735,0.0045590894,0.0043208343,-0.02901072,0.04550218,-0.009531129,0.07670911,0.06494192,0.012202002,-0.0028825076,-0.11320491,-0.052684154,0.021178452,-0.061368123,-0.0102144405,-0.09802622,-0.05593923,0.055199318,0.113545515,-0.009590196,0.034115504,0.058160927,-0.09299075,0.013101722,0.075839125,-0.043779843,0.03166356,0.04420346,0.0590171,0.07064177,-0.0016083536,0.010337901,-0.07620542,-0.04880853,0.009823858,-0.02448653,0.03165964,0.028433342,0.07139664,-0.045923434,0.048993897,0.07190658,-0.009067171,-0.022510927,-0.029821323,-0.08238717,0.01784026,-0.033546574,-0.005492803,-0.014987696,-0.016786141,0.12816364,-0.017835258,0.01573371,-0.060100134,-0.06622785,0.019883366,0.062161326,-0.025768336,-0.04129447,-0.011074136,0.007879426,0.013000267,-0.057486452,0.061738767,-0.01911598,-0.014212116,0.04117812,0.06893729,-0.020521872,0.005555439,-0.03229914,-0.028815446,-0.013872695,-1.7924823e-33,0.074818544,0.03238616,0.010134631,-0.043976184,0.007503276,0.055969797,0.03464211,-0.055823334,0.05978228,0.022815375,0.1001197,0.04772285,-0.06041774,-0.11069514,0.0682022,0.019606618,-0.00936117,0.04670764,-0.04296577,-0.010037067,0.08947329,-0.043124884,-0.09578015,-0.00016775535,0.058246326,-0.024760514,0.04722012,0.030474875,0.022933017,0.07615543,-0.060176235,0.0534393,-0.06152634,0.0071490565,0.07187388,0.060930956,-0.09583164,-0.008166597,-0.049700312,-0.071387365,-0.04723373,-0.0029157482,0.014573659,0.074056186,0.12029934,0.102887124,-0.038704794,-0.013097362,0.059333205,0.0070852875,-0.016292704,0.011953357,0.003296115,0.059654854,-0.037293192,0.057554066,0.019966075,-0.010027335,-0.097725034,-0.049791142,-0.023839446,-0.0020407855,0.049044732,-0.05602665,-0.042420838,0.061051033,-0.014881362,-0.03245487,0.05425352,-0.0063948412,0.03833986,-0.11863847,0.030823337,-0.00991368,-0.08017744,-0.050417356,-0.02550649,-0.037577916,-0.06900217,0.018174384,0.14787799,0.050430726,0.014060385,0.016078075,-0.00058144046,-0.015106964,-0.011226877,0.11048289,0.009379285,0.029546635,-0.028452558,0.019835006,-0.11241893,0.0035914995,0.07467026,-3.5404284e-08,0.0210502,-0.089780964,-0.018223215,0.0171609,0.0416681,-0.0047409814,-0.06076775,0.008972115,0.014983419,-0.004335678,0.010167314,0.07021834,0.036523227,0.012718325,-0.004412502,-0.0093993945,-0.02328214,-0.013468974,-0.028293569,0.0500501,-0.14529333,0.009430289,-0.057482176,-0.0002972639,0.04035043,-0.036751032,-0.018650373,-0.026220722,0.004493981,0.00072800834,0.068841495,0.062887125,0.025967333,0.023898877,-0.01868948,-0.050326135,-0.009359741,0.034156416,-0.031528804,-0.017757533,-0.015439592,-0.10641317,-0.012155514,0.022395886,0.03789438,-0.01886387,-0.099196576,-0.00802574,-0.061709497,0.02858698,0.010085171,-0.020310085,0.00063760486,-0.021391775,-0.02891439,0.0034196647,-0.10950855,-0.09212906,-0.049280435,-0.07490978,0.04465954,-0.005810348,0.21639629,-0.029853905 +1.1.1.231,Specific for prostaglandin I2.,384,0.99999994,-0.08600432,-0.0029193684,-0.1235661,-0.048159838,0.021017084,-0.029560976,0.006124176,0.1915966,0.018892402,0.008096074,0.032271676,0.021963775,-0.07695992,0.067190886,-0.06514373,0.0025150867,0.05122219,0.007108359,0.0022589238,-0.059098642,0.06003349,0.025911257,0.04681149,0.00031085138,-0.032691654,-0.025927242,0.005249095,0.07257687,0.05388722,-0.00970645,0.0034566165,-0.06326378,-0.0057472945,0.0049571227,0.030141326,0.04012209,-0.033295937,-0.010732558,-0.007037442,0.016870989,0.07574817,-0.023909828,-0.06531122,-0.033327345,0.020555958,-0.020982677,-0.081547424,0.06736563,0.023074213,0.11786799,-0.004534976,-0.035848808,-0.017345179,0.06560652,0.039820522,-0.053345513,-0.058745414,0.03175327,0.0073116594,0.118531525,0.003903218,-0.07404588,-0.015838098,0.012584867,0.038129766,0.01595446,0.017477358,-0.06531299,0.008892562,-0.0070149465,-0.034334004,0.024472224,-0.0081065865,0.049535368,-0.0032621564,0.0040541743,-0.057375565,-0.1096123,-0.07607515,-0.07336067,0.020355312,0.064654835,0.07407117,0.070864715,0.046933018,-0.0035223148,0.059578326,0.06951522,-0.027025888,0.029147968,0.059903428,0.0040085274,-0.00062603544,0.02419147,-0.039682884,0.053801794,-0.025736429,-0.062874794,-0.006638282,0.010831355,-0.0728165,-0.058967847,-0.049803082,-0.10377176,-0.030928206,-0.00090768817,-0.015742943,-0.0029405383,-0.0048757396,0.020871004,0.034196764,0.0009150069,0.018357374,-0.00012814284,0.030506449,0.106744036,0.004389546,0.04387335,0.061089303,-0.023101373,0.0011489962,-0.01682431,-0.0026319022,-0.022973437,-0.094598345,0.03120449,-0.015077692,7.817523e-34,0.042074375,-0.010251664,0.019644892,0.08478457,-0.02254023,0.01081968,-0.106100835,-0.07276314,0.025230834,-0.033418443,-0.044580717,-0.044082765,-0.025455387,0.043186106,0.003228026,-0.055868953,0.04361807,0.03675258,0.050038695,-0.009621319,0.055045024,0.05194086,-0.01531784,-0.041419517,0.035025675,0.14570943,0.045791827,0.045471873,0.01403463,-0.011115241,0.047540754,-0.054079853,-0.059660994,-0.0014094299,0.04630128,0.011571992,-0.053348288,-0.046199396,0.009653711,0.053988162,0.02022307,0.027439462,-0.013184631,-0.010338561,0.09792849,-0.108667366,-0.060154766,0.023643572,-0.0063006533,0.009986959,0.0048535718,0.023680523,0.03826471,-0.014002143,-0.082044154,0.01350247,-0.00044324243,-0.022352643,0.07919517,0.07705414,0.0008383061,0.051316317,-0.020208986,0.029020522,-0.04162204,0.019586915,-0.14284737,-0.05057433,-0.119210005,0.018829554,-0.02334896,-7.688435e-05,0.16460669,0.062419116,0.014171014,-0.007082823,-0.032098908,0.010611651,-0.072652645,-0.013999085,-0.11562834,-0.029834008,-0.05469858,0.09729292,-0.10077643,-0.058132626,-0.03599069,-0.07255858,0.007931542,-0.012512964,-0.0059849704,-0.0045303046,-0.08065063,-0.020081853,-0.010193962,-2.3865555e-33,0.015003129,-0.028234286,0.09054976,-0.019725787,-0.009104185,0.10808665,0.03725214,-0.009477,0.015663752,0.036591653,0.085875064,0.018224094,0.016663766,-0.013812033,-0.017902179,0.05175681,-0.057744272,0.0034450039,-0.058375124,-0.009704962,0.029099133,0.061092086,0.023956403,0.05060031,0.084348075,0.027801493,0.0564941,0.02012656,-0.06362311,0.0522498,-0.013564093,0.0013082947,-0.14934953,-0.046246916,-0.05372074,0.004227285,0.005390444,-0.08949371,-0.11292659,-0.043527886,0.0065480727,0.02189801,0.0066790567,0.08270425,0.020192306,0.08375985,0.042384125,-0.029132357,0.0019259233,-0.035302214,-0.079404645,0.02758355,0.024145594,-0.01811203,0.039987713,-0.05038639,-0.019752264,-0.052466106,-0.037840404,0.058087572,0.029085008,-0.037877303,0.003270117,0.013058111,-0.002102485,-0.015692053,0.05923552,-0.05685479,0.093602866,0.008636489,0.09442445,-0.04977515,0.018537851,0.003970005,-0.0954091,-0.020362755,0.002524313,-0.042587884,-0.026341781,-0.051208608,-0.008315991,-0.053049557,-0.014784004,-0.03214337,0.04358738,-0.013435404,0.013100285,0.079738185,-0.045618568,0.0058244807,-0.057689715,0.097602434,-0.0768518,0.029674517,-0.018401606,-1.8918396e-08,0.058271516,-0.029027173,0.14228828,-0.016765058,-0.028403677,-0.0671174,-0.048638735,0.020518906,-0.018664524,0.0063707926,-0.05758769,0.09767482,0.07022083,-0.08037823,0.013748009,0.07808969,0.05328398,-0.013969797,-0.03463362,-0.02973097,-0.06963309,-0.043593936,-0.037183437,-0.05379652,-0.05147398,-0.05237449,0.07566238,0.060573805,0.010973926,-0.038025822,0.027534062,0.020736821,0.038974117,-0.03576605,0.044433292,0.11642316,-0.011302848,0.036128994,0.0038808638,-0.039875183,-0.013472747,-0.038730633,0.047815267,0.045138177,-0.0042454065,0.021795178,0.016153332,-0.00035724396,-0.0038684048,-0.011021186,-0.032847393,0.0034920396,-0.009655553,0.007691356,-0.0723398,0.13108964,-0.033894826,-0.035265006,0.010293465,-0.0592095,0.058251712,-0.012638237,0.068468265,-0.027548794 +1.1.1.233,Acts on acetyl-D-mannosamine and glycolyl-D-mannosamine. Highly specific.,384,1.0,0.006557186,-0.06843066,-0.039712265,-0.030680632,0.039325565,0.036489002,0.038856346,0.02021112,-0.020809079,0.14229336,0.0011505904,0.015829332,-0.042281475,0.027555857,-0.04939873,0.086207874,-0.017527848,-0.011436511,0.011254659,0.046632394,0.044063702,0.0016783994,0.02325793,-0.013527408,-0.015797582,0.05531859,0.008451697,0.0030646145,-0.056215163,-0.14057851,-0.045529664,-0.026756966,0.00036082917,0.040020306,0.048955813,0.047169384,-0.024110317,0.06544687,0.046065483,0.00562958,0.05163854,-0.07843399,0.008322292,-0.0532846,-0.031847302,-0.047383,-0.045684412,0.014194018,0.042090658,0.08542814,0.02719249,0.0028853633,-0.016902156,0.07156973,-0.04347389,0.026441118,-0.08439161,0.02452468,0.037190046,0.03314127,-0.046111837,-0.0022796534,0.04666123,0.006288606,0.031235937,-0.046213005,0.028317705,-0.048172425,0.014743777,0.029276213,0.03287017,-0.09153476,-0.009174131,-0.039702594,0.040509924,-0.021672735,-0.024031758,-0.101253845,0.054820705,-0.022497704,-0.044920877,0.07767652,0.13518953,0.044229813,0.002906639,-0.005336631,0.00539964,-0.021424744,0.049394656,0.038426135,-0.024950542,-0.07610845,-0.002602645,-0.027100587,-0.04913077,-0.067122184,0.036327057,0.00563526,0.0066735735,0.010604597,0.01739191,0.009651372,-0.09297576,-0.09819779,-0.011269939,0.02568059,0.0017387954,-0.042842165,-0.006275733,-0.014702596,-0.037369587,0.017472005,0.004520886,0.02948738,-0.09636627,0.05468769,0.03210648,-0.06192843,-0.026019005,-0.058928937,0.028153323,-0.013396914,0.040208086,0.04491515,-0.030324373,0.06130739,-0.031025257,-1.2606728e-33,0.05038708,-0.02673896,0.070927024,0.022808203,0.032322776,0.010277836,-0.06501578,-0.028752761,-0.006827887,-0.021734752,-0.074545175,-0.0161624,0.04315728,0.11058477,-0.050859213,0.076788776,-0.05845558,-0.031131424,0.040412467,-0.09716537,-0.010367122,0.14534226,-0.09757938,0.034412105,0.0073248637,0.03709923,-0.04893391,0.082329236,0.027464407,0.0009947778,0.02391261,-0.020974418,-0.040171243,0.038009208,-0.020309467,0.11255399,-0.039479908,-0.0019704634,0.043774452,-0.019075617,0.030759145,0.03228449,-0.052720208,-0.04485165,-0.0649098,-0.007898441,-0.03200305,0.02558171,-0.005323087,0.05483134,0.039456885,-0.07893968,0.062543064,0.009201181,-0.056397185,0.049797975,-0.09698423,-0.09875976,0.06901515,0.10060599,0.026199076,0.009240331,-0.0065871063,-0.02063774,0.015064615,-0.004866344,-0.04931082,-0.027957859,-0.017221479,-0.029389596,-0.060984258,-0.041372985,0.13371821,-0.014109386,0.008323282,-0.016854012,-0.0065955566,0.02199347,-0.035422027,0.05611912,0.022151278,-0.10514727,0.02505547,-0.0061546895,-0.075106405,-0.024201164,-0.035979934,-0.15317258,-0.056500215,0.037431672,0.006709618,-0.04783932,-0.09576477,0.0086759785,-0.044474483,-2.7014137e-33,0.038083415,-0.0873701,0.10762913,0.017420104,-0.053157024,0.075987175,0.0452427,-0.03499361,0.025758477,0.022850264,0.022559308,-0.039945576,-0.0304451,-0.0032422778,-0.031835724,-0.012493045,-0.009845332,0.046786763,-0.008357205,0.03341337,-0.0771909,0.09024524,-0.035865113,0.027094463,0.07876615,-0.0004713242,-0.018904386,-0.040716033,0.0018539452,0.07709667,-0.0016163904,0.061201967,-0.054564912,-0.046899904,-0.0068632034,-0.0020315996,-0.04025329,-0.024426373,-0.11146909,-0.07000417,-0.06179192,0.006578947,0.06537001,0.052970763,0.09587886,0.086237855,-0.040445175,-0.02092355,-0.12277661,0.0014754254,0.0024517337,0.020074626,0.012524315,0.012956724,0.059090953,0.077754654,-0.01040649,-0.052289084,-0.012720731,0.012007907,-0.0058335974,0.013541047,-0.030523492,-0.051878724,0.07650269,0.054437943,-0.045161445,0.027949614,0.06266947,-0.028927077,0.054349266,0.017314903,0.07053339,0.050480243,-0.052508954,-0.060428582,-0.056326374,-0.063755065,0.008811443,-0.05607264,-0.025823249,0.01743945,0.018689578,0.011155453,-0.08124954,0.050848193,0.012144299,0.09971722,-0.043579083,0.08586992,-0.038170334,-0.005564864,-0.102177255,0.052443527,-0.006766786,-2.778022e-08,0.08990668,-0.021274613,0.077130675,-0.097643785,-0.05529718,0.04520572,0.033575065,0.073771656,0.026775321,-0.04345194,-0.023618024,0.13703348,0.10960707,-0.042285316,-0.0016239203,0.010034201,-0.020260144,0.035485215,-0.04706133,-0.007001522,-0.14658687,-0.0027989862,-0.025589842,0.046605296,-0.03221649,-0.023034347,0.08241729,0.092860274,-0.030246722,-0.0023995328,-0.011264867,0.025912972,-0.03801433,-0.09663665,0.02530658,0.019520031,0.000545179,-0.074178234,0.028814964,-0.012800593,-0.030522883,0.015006675,0.013409734,0.014744127,0.016109603,-0.00015135064,-0.011536904,0.0027195734,0.03051514,-0.014557503,-0.016509729,0.048161093,-0.054227285,-0.058544423,-0.11079224,0.024510408,-0.04196391,-0.06418287,0.03943656,-0.076255575,0.033810366,-0.014715164,0.05059092,0.03504222 +1.1.1.234,Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol.,384,1.0,-0.10523772,-0.042556044,-0.18985511,0.0020927212,0.017913494,-0.013442599,-0.036830433,-0.0091502825,0.027253542,-0.050973907,0.045058202,-0.07534791,-0.01716822,-0.031818625,-0.010160996,0.03863045,-0.062809855,0.12571993,-0.10016297,-0.029566355,0.018580511,0.03768653,0.05226658,0.028862962,0.037565425,-0.050241634,0.02308592,-0.022910656,-0.05514634,-0.049452633,0.04768482,-0.032100655,0.048561245,-0.0079724295,0.05931726,0.08047505,-0.12119864,-0.04664262,0.074819,0.009466902,-0.021426542,0.028770328,0.059608866,-0.07443819,-0.017107846,-0.0435763,-0.10144982,0.02386184,0.075549476,-0.031949878,0.02473748,0.0765284,-0.062292695,0.014638797,0.06805019,0.02033966,-0.043600146,-0.040468644,-0.10254428,0.07455924,0.039124824,-0.007902906,0.002959988,0.013284294,-0.100559235,0.012413423,0.031010555,-0.015359356,0.078538395,-0.033266746,-0.027095724,-0.03948452,-0.014856599,-0.033169422,-0.032310586,0.076702036,0.03952172,0.045500465,-0.07723342,-0.014893629,0.048527863,-0.019073963,0.07732681,0.022801725,0.00047151177,-0.0353905,-0.049774546,0.006768223,-0.023990728,0.13110244,0.043362793,0.03584483,0.078153625,-0.012722099,-0.0044972855,0.027495086,0.10631217,0.020053884,-0.05277615,0.0048442474,-0.019905174,-0.039375223,0.030481307,-0.019350167,0.04873942,-0.0739019,0.024309216,0.0060581984,0.011753658,0.0027885314,0.041023888,-0.048060242,0.008214868,-0.049386602,-0.033274125,0.057642326,0.008897796,0.028440114,-0.03900409,0.047035635,-0.03283511,0.0019522225,0.032255694,-0.061836027,-0.0030906885,0.003606068,-0.027279964,3.2788075e-33,0.09982552,0.046794567,-0.028327074,0.00877586,-0.001053416,-0.0042095007,-0.028713563,-0.017899089,0.044662107,-0.08670042,-0.14094716,-0.006009262,0.035671156,-0.04209753,-0.012006112,-0.026984036,-0.074705645,-0.046964858,0.039728492,0.012075019,0.034067534,-0.041102342,-0.079851635,-0.031742133,-0.07210296,0.027670769,-0.031260084,0.036802296,-0.052966062,0.005968808,0.033174366,-0.12580992,-0.0046375315,0.052918445,0.087283574,-0.017086193,-0.038863253,-0.03660839,0.021792248,0.03484096,-0.051011715,-0.018229043,-0.061721135,0.0050892094,0.0041630436,0.05629276,0.015398589,0.08690949,0.00086278503,0.080495045,0.019480497,-0.02353103,0.13970093,0.07060804,-0.019652342,-0.06995242,0.026667053,-0.035406806,0.08191614,0.055474002,-0.03786955,0.017008428,-0.018404217,0.006234672,0.04081104,0.02941661,-0.060615774,-0.008506995,-0.004825831,-0.043318834,0.030733379,-0.1070313,0.032758344,-0.010071285,0.10433174,0.02480701,-0.049256314,0.021548301,-0.00670094,0.046281926,0.009362564,0.057949618,-0.022292797,0.033627804,-0.025216775,0.013850006,-0.051732358,0.019174015,0.043287706,0.035062086,0.01336296,-0.05363472,0.008906251,-0.03422536,0.07667264,-3.1302305e-33,0.05614193,-0.017728776,-0.06598188,-0.0055747004,0.04231134,0.021883983,-0.0027250499,0.0037200518,0.0034538985,0.021049019,0.0331325,0.0045792027,0.016905783,-0.016846955,-0.05519985,-0.02717995,0.058539085,0.097695366,0.035376523,-0.028909609,0.030724615,-0.019254684,-0.06350242,-0.058426145,0.018180655,0.013664728,0.0047761914,-0.070252284,-0.061861873,0.094792135,-0.026317267,-0.0015667584,-0.045491774,0.06567111,-0.025692854,0.06396241,-0.008468066,-0.002960151,-0.066128,-0.030584106,-0.01271977,-0.014804244,0.0013772938,0.08252321,0.048417192,0.031154232,-0.047728583,0.0008735056,-0.030080741,0.01225285,0.026173012,0.063824974,0.015839178,0.02904925,-0.012456099,-0.019950066,0.081548885,-0.009098568,0.01985739,0.01351825,-0.0903792,-0.071885586,0.023315094,0.03575002,0.0067287795,0.09114713,0.04900678,0.084011465,0.09545504,-0.12638849,0.051907122,-0.049074236,0.06986113,0.02915171,-0.042698435,-0.016398758,-0.043538284,-0.031349014,-0.020601101,-0.013635004,0.058835063,-0.0627407,0.041444313,-0.006500369,-0.08271858,-0.04498409,0.092755385,-0.018375272,-0.087220326,0.0029004365,0.021547897,0.05590404,-0.062273543,0.09680539,0.061842415,-2.4075668e-08,-0.008740877,-0.051413286,0.047196507,-0.019446243,0.05434894,0.0545527,0.016496042,0.07134694,-0.004972181,-0.043182243,0.03264828,0.102102615,-0.056847423,0.033159427,0.07001771,0.0059286663,0.034942172,0.023126703,-0.008013254,-0.0024563123,-0.06409249,-0.014024192,-0.056252126,-0.06937996,-0.0068712276,-0.04288692,-0.030582635,-0.009334282,0.11092944,-0.0073480234,0.06541869,-0.0025268374,-0.021424044,-0.018139288,-0.09012679,-0.07480014,-0.047217105,-0.082911156,-0.04018103,-0.021081898,-0.13765755,0.043272264,-0.0050934083,0.03539717,-0.05145542,-0.0063675647,0.0015519976,0.061222542,-0.00027168088,0.0013287985,0.021348894,-0.08021003,0.012245549,-0.045781884,-0.058032293,-0.0061733676,0.06572292,0.009275315,-0.038894355,0.063517585,-0.100158624,0.059250597,0.13316211,0.031931825 +1.1.1.235,Si-specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin.,384,1.0,-0.016621588,0.06443034,0.008558538,-0.02027426,0.025857385,-0.014745229,0.011091523,0.13907921,0.070431925,-0.032608196,0.025850696,0.017760186,-0.0012099704,0.070487045,-0.040657807,-0.025929676,-0.04189983,0.081937134,0.010436446,-0.04057909,0.013114917,0.013000358,0.061234575,0.029861705,-0.010442119,0.01181128,-0.019876117,0.06867983,-0.024018768,-0.104413725,-0.00095489965,0.082433484,0.083243355,-0.07389057,0.014579621,0.038466435,-0.061395504,0.001987557,0.017633406,0.021243773,-0.009671309,-0.020476146,0.00692707,0.040203497,0.0034971912,-0.011697184,-0.07440677,-0.0033973611,0.037932396,0.07968839,0.013488019,0.018869236,-0.032433894,0.08116316,0.08481225,0.020982329,-0.03189174,0.017585013,-0.01334679,0.008558975,0.014833125,-0.0754572,0.03395892,0.03862546,-0.008357023,0.021515802,0.09557408,-0.08716365,0.0102036875,0.007756811,-0.019820988,-0.010403235,0.016924435,0.07190556,0.020224802,0.018949268,-0.030186974,-0.05890952,0.03430418,0.04336111,0.025446827,0.1307358,-0.025615389,0.036937766,0.11944863,0.05198061,-0.043808077,-0.026757292,-0.029595431,-0.024147363,-0.01950201,-0.0067977756,-0.02638159,-0.019863999,-0.01223619,-0.012585492,0.013247423,0.01664391,-0.050597638,-0.040566932,0.041126955,0.07499641,-0.078738086,-0.015594755,-0.0023044986,-0.04261263,0.09527528,0.017887307,-0.049056567,0.027933078,0.013575556,-0.016197655,-0.007685666,-0.05888471,-0.05162205,0.10766924,0.07272011,0.1014072,-0.030065408,-0.0603934,-0.021998446,-0.049172375,-0.08892599,-0.0839911,-0.020760808,0.033821147,-0.060700364,2.4287958e-33,0.05536959,0.11692095,-0.06194029,0.059825826,0.05790683,-0.021027222,-0.05166207,-0.048869383,-0.015379163,-0.07656212,-0.07756554,-0.06565493,-0.0046153483,0.03880709,0.012537031,0.003939031,-0.02592295,-0.0071131038,-0.033615716,-0.07651426,0.07575207,0.05353701,-0.006628578,0.016672624,0.078697085,0.009469986,-0.08278738,0.07933948,-0.022017023,-0.033999432,-0.055623937,-0.036871053,-0.038339995,-0.052465536,0.038765494,-0.028139262,-0.124667965,-0.07393307,0.069284774,0.0570299,-0.028718952,0.10731067,-0.009157698,-0.014222486,0.06863704,-0.03904168,-0.04305126,0.06778838,0.0031960974,-0.019427458,0.060312755,-0.03805515,-0.011510483,-0.10803937,0.00869363,-0.01234981,0.007848607,-0.047988653,-0.0463718,0.048575293,0.07491314,-0.039556015,0.018225616,0.071840696,0.027730104,-0.011346153,-0.11154624,-0.0154223135,0.0059910067,0.0106137665,-0.028216,-0.009420544,-0.018176284,-0.0010071442,-0.028556794,-0.014494553,-0.010014387,-0.019708196,0.12373356,-0.0102945855,0.02112246,-0.04410932,-0.058000688,0.003382137,-0.046630982,-0.0080133155,0.062582605,0.022751251,0.038249977,-0.03961343,0.031169511,-0.073448695,-0.04291548,-0.049118176,-0.07267347,-4.100212e-33,0.045341928,0.008468382,0.103330016,-0.059138786,-0.04219549,0.09890869,0.03676277,-0.16197437,0.050553836,-0.014859662,0.07298506,0.0069319955,-0.03577527,-0.083224505,0.0063302154,0.004831199,-0.0379162,0.010488636,-0.029120076,0.028101208,0.05768265,0.08717644,-0.02500131,-0.026596967,0.010142868,-0.06534072,-0.048253052,0.036291428,0.022641877,0.043177117,-0.02438522,-0.08486815,-0.05986038,-0.047501825,0.059740692,0.07023161,-0.0059170467,-0.0056797476,-0.070724905,-0.023932623,-0.0013223186,-0.070023455,-0.03443918,0.063863486,-0.018567273,0.042602804,-0.030184966,-0.011956556,0.031703576,-0.0172428,0.047101736,-0.022902742,-0.03534892,0.021835122,-0.039089948,0.02062991,-0.07236962,0.00038055886,-0.05204545,-0.037350502,-0.039354302,-0.024489414,0.023506975,-0.010590089,-0.005223248,0.084222466,-0.026277222,0.022020884,0.0717359,-0.124262564,0.032493137,0.02100602,0.043611135,-0.034722846,-0.12787291,-0.12605128,-0.08305015,-0.028587127,-0.018920587,0.06310535,-0.08130256,-0.03689786,-0.074952774,0.036112934,-0.010779716,0.06688677,0.03239621,0.017491162,-0.012316242,0.043819807,-0.017334402,0.017898617,-0.026951779,0.05170122,-0.034671273,-2.9405657e-08,0.07320828,-0.044938244,-0.0006719624,-0.06473663,-0.044145286,-0.051134482,-0.014227635,-0.034046844,0.021803947,0.052857466,0.008281708,0.1416543,0.041098353,-0.01716068,0.09206707,0.008339859,-0.043612715,0.04522282,-0.013973982,-0.042138062,-0.030504394,-0.004551232,-0.027106881,0.039346825,0.06059139,-1.8330047e-05,0.078468755,0.023970008,0.04643953,-0.027429875,0.097849324,-0.007244567,0.01917661,-0.027774217,-0.017837644,0.026164303,-0.0028565063,0.011257733,0.035813194,0.047472343,0.017679928,-0.044311706,-0.07040727,0.10168731,-0.046340294,-0.021043627,-0.015280296,0.053486433,-0.072317116,0.037023228,0.048297983,0.007018286,-0.007945779,0.0049509034,-0.084498085,0.031480383,-0.0022550735,-0.030344252,0.04423766,-0.053987876,0.011396175,-0.028669689,0.19029611,-0.030268159 +1.1.1.236,"This enzyme along with EC 1.1.1.206, tropine dehydrogenase, represents a branch point in tropane alkaloid metabolism [3]. Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [3]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [2].",384,0.99999994,-0.015095572,-0.07342441,-0.15778454,-0.045035705,0.007820326,-0.014206071,-0.022865197,0.07053904,0.045041215,-0.04742413,0.045720004,-0.057667863,-0.012269769,-0.026967669,-0.019002007,-0.019923972,-0.07523424,-0.08103166,0.12152763,-0.07201058,0.050767925,0.049293555,-0.021637224,0.058899764,0.04219959,0.004290691,-0.021357851,0.04285243,0.012063825,0.012673826,-0.029484518,0.028612208,0.02471607,0.008606908,-0.010966565,0.10050165,-0.13795342,-0.018765135,0.01958455,0.061031327,0.035502642,0.0044485787,-0.06288857,-0.011624002,-0.07720931,-0.085516095,-0.02491341,0.10458136,-0.04378748,0.038498867,-0.038790792,-0.009278282,0.041508462,0.099943735,-0.07849225,0.044074193,-0.04447957,0.06880607,0.0024548364,0.07188813,0.006527722,0.06525957,0.019554581,-0.047896612,0.050939027,-0.028152892,-0.004466032,-0.062306892,0.10968356,0.007338238,-0.054929897,-0.018101132,0.06347159,0.074422665,-0.02291755,0.0052899877,-0.04817897,-0.043146607,-0.099290535,-0.051013093,0.034057144,0.016190715,-0.0012054732,0.02240404,0.03327591,0.005290797,0.014418693,0.10443905,0.01929726,0.002350546,0.12981783,0.0060545863,0.016338663,-0.063190974,-0.057723984,0.07022479,0.014870428,0.041733272,0.014329595,-0.09841604,0.024251137,0.009255184,-0.082558386,-0.001315136,0.027554518,0.03892103,0.034637038,0.005902441,-0.04633201,0.00296359,0.024103424,-0.007978602,0.052735265,0.017360035,-0.012667736,0.112112485,-0.0007339166,-0.026144607,0.012001991,0.017864136,-0.039698865,0.03387557,0.039209466,0.057916716,0.035960253,0.0064394334,-0.12504321,2.7933992e-33,0.0113073485,0.04790716,0.0011101773,-0.06758095,-0.014122716,-0.019469542,-0.11949199,0.0005891682,-0.020690732,0.0049577146,-0.11717893,0.022741858,0.0061444473,0.00043750147,0.054995574,-0.027338164,-0.05882726,0.086314775,0.08203199,-0.018217744,-0.0074044424,0.068430915,-0.12964618,0.0031861581,-0.034355655,0.0736022,-0.017086115,0.08628782,0.009906076,0.002330541,0.0045945607,-0.07570397,-0.042544957,-0.0043720114,0.026786217,-0.055018444,-0.015379712,-0.0076625226,-0.08293504,0.09077292,0.024434285,0.09339274,0.069138184,0.01884277,0.028225776,-0.04745051,-0.015751503,0.0622246,0.07092473,0.027637944,-0.027651533,-0.055031735,0.07525524,-0.022497693,-0.08011746,0.025636936,0.0015317168,-0.037721295,0.05223576,0.098900184,0.01721657,0.028617794,-0.016486596,-0.040845808,-0.043285657,-0.004036942,-0.045287665,-0.1028386,-0.027924152,0.057340626,-0.13723472,0.02449559,0.086562246,0.021750085,0.0806197,-0.020828208,-0.03472339,-0.010695215,-0.06610263,-0.026004031,-0.037302822,-0.08233608,0.023895806,0.001730921,-0.0029837415,0.007540999,0.0006928982,-0.026077464,0.0025577615,0.050174367,-0.028502833,-0.03884479,-0.074382775,0.03506524,-0.028933704,-2.9221315e-33,-0.00621996,-0.04620227,0.08344357,-0.06165879,-0.06840749,0.12796026,-0.023383968,-0.0847686,0.023217471,-0.015253235,0.093808405,0.017337061,-0.005988323,-0.042915605,0.03578806,0.036352657,0.0016567592,0.02682171,-0.021788653,-0.038475428,-0.05258048,0.049098503,-0.05484367,0.04295281,0.009556511,-0.024059195,0.08305105,0.0620933,0.041900367,0.097734004,-0.01882427,0.0011661553,-0.07250435,0.0005484665,-0.020970115,0.01448025,-0.08071783,-0.0014811342,0.04530581,0.024627196,0.026436059,0.008546524,0.036310434,0.03715978,0.024429308,0.0077649234,-0.025579164,-0.013497381,-0.049367655,-0.057950538,0.03880291,0.039482772,0.026621439,-0.03418019,0.05016982,0.017281696,-0.04704482,0.039660204,-0.043704193,-0.055586834,0.038028434,-0.01643335,-0.010469133,-0.029097363,0.040611006,-0.0113460645,-0.04064587,0.08369874,0.02722716,0.024364412,0.029609403,-0.0018527482,-0.010430622,0.046749733,-0.029323943,-0.0045089736,-0.032691937,-0.05413157,0.059397753,-0.019278817,0.015562415,0.05788581,0.004315292,-0.09787509,-0.0043129874,0.052309368,-0.019509386,0.10967701,0.03609909,0.05683294,0.060706675,-0.01746539,-0.07219755,-0.0066902977,0.039909188,-4.0960575e-08,0.02979665,-0.027579088,0.0001566581,0.04531136,0.011302697,0.033159565,-0.004279224,-0.03739371,-0.0001873726,-0.023843015,-0.053856336,0.009321472,-0.0066949665,0.067166135,0.018245904,0.0415962,-0.088102266,0.018033365,0.01455825,0.052295376,-0.068632945,-0.019823425,-0.09838719,-0.01783989,0.033062335,-0.016567865,0.026066272,0.063615784,0.03806031,0.02061252,-0.0034489515,-0.02079405,-0.060374435,0.004871057,-0.0013238633,-0.009675195,-0.072674684,0.04017005,-0.08608636,0.049105644,0.06265086,-0.069828935,-0.04934116,0.015146713,-0.0056926105,0.042286094,0.04647068,0.020170098,0.060380798,-0.02212494,0.050788086,-0.042245753,0.055732254,-0.05520446,-0.08285389,-0.0476271,-0.073130056,-0.12001457,-0.054151814,-0.04603068,0.0021310884,0.022464678,0.17210591,0.0021138655 +1.1.1.237,"The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.",384,1.0,-0.07431597,-0.08084969,-0.11825838,-0.03085757,0.07069647,0.0050661387,-0.124560066,0.0002053927,0.060966376,-0.012080323,0.01109444,0.016778355,-0.107200645,-0.026624024,-0.048439663,0.070016325,-0.061878376,0.012834983,-0.014329181,-0.052206174,0.07559239,0.01291879,0.06058586,0.01589339,0.07184078,0.033889454,0.06552648,0.022242505,-0.0093367165,-0.04284611,0.02304063,-0.06216408,0.024816724,-0.044722605,-0.0061277314,0.06506115,-0.009860636,0.011467416,0.04636082,0.065437496,0.0061909766,-0.025771013,-0.036899675,-0.0044173296,-0.043110967,-0.06981566,-0.05793113,0.031133402,0.039720405,0.059230838,-0.060322702,-0.033443492,-0.023534875,0.003308781,-0.023419043,0.06267621,0.025876142,0.00713184,-0.06160177,0.0022309294,0.04560312,-0.026793689,-0.023468846,5.324684e-05,0.027511561,-0.07731828,-0.01266769,-0.0411741,0.03358395,-0.09360556,-0.0700053,-0.07120151,0.0019706204,0.009249638,-0.035675954,0.016848423,-0.06604497,-0.02544622,0.045510735,-0.048073437,0.09192587,0.0027133506,-0.023770066,0.069321185,0.09977254,0.026950527,0.0056161094,0.01761054,0.0597991,0.047764968,-0.018988665,-0.041311406,-0.007317772,-0.044904467,-0.046589065,0.027132954,0.05326023,0.029432975,-0.061509814,-0.013157112,0.026257437,0.086119354,-0.03417564,-0.081562705,-0.06226121,-0.0059468043,-0.049216483,0.095978044,-0.085407585,-0.016031971,-0.012567171,0.00043505733,0.04177803,0.03664771,-0.034002468,0.10074665,0.028912602,-0.031974364,-0.057114936,-0.07113106,-0.009958637,0.008473298,0.025410274,0.08492403,0.043049205,0.031702533,-0.10365887,-2.3130496e-34,0.08238555,0.0216787,-0.029545588,0.01168076,-0.03791724,0.031167869,-0.08384591,0.066006795,-0.036355786,-0.018710753,-0.057231314,-0.06474941,0.0544737,-0.022604996,0.011787431,0.011632506,0.012194887,-0.027529856,0.032057483,-0.009925547,0.026891045,0.07521403,-0.0695752,-0.0044693206,-0.026490793,0.011554342,-0.04484244,0.04745515,-0.020367349,-0.0033222004,0.058576856,-0.07118167,-0.041532665,0.0040538125,0.04934678,0.028332517,-0.07105872,-0.07206585,-0.033422124,0.043252442,-0.054204304,0.01903608,0.040584315,-0.028693158,0.01456283,-0.05422521,0.034621555,0.052199416,0.06399755,0.055603653,0.019834653,-0.0029246225,0.11440621,0.0019438536,-0.019854013,-0.023329647,-0.05881667,-0.026628263,-0.011839772,0.10996485,-0.030168885,-0.0046149907,-0.025206482,0.09274592,-0.0063854344,-0.028501539,-0.05649527,-0.065887176,-0.017526358,0.08224006,-0.0037378352,-0.04064503,0.053377617,0.005547057,-0.0030299157,-0.032920625,-0.004096888,-0.023546113,-0.031194963,-0.042318594,-0.055740256,-0.015020411,0.007243181,0.026978532,-0.04692543,0.01590287,0.011743071,-0.049704492,-0.05912278,3.183605e-05,-0.0034154044,-0.09605133,-0.044491228,0.059719197,0.104231104,-2.3338919e-33,0.04259994,-0.07679533,0.042597897,-0.14215086,-0.06782249,0.10516668,0.031071134,-0.022417607,-0.02172534,-0.031373546,0.027981514,0.030557638,0.010730783,-0.027515376,0.05088989,-0.011158079,-0.045159545,0.025946384,0.034898926,0.013022843,0.029350199,0.15361318,0.07042644,0.042694427,0.0863201,-0.043832563,0.0680269,0.060186632,-0.0050255293,0.052240323,-0.017860746,0.016395578,-0.03663801,0.0122525,0.012644136,0.09668077,-0.08824457,-0.0004533607,-0.03385082,0.08412162,-0.016243193,0.01961425,-0.03034388,0.054329187,0.053961586,0.0010933827,-0.10289093,0.04664559,0.0089146765,-0.11898839,0.017874017,0.005969624,0.03421219,0.04287697,0.09152212,0.07713836,-0.046192072,0.053344622,0.016456865,-0.02306995,-0.021102414,0.011154767,-0.0004321601,-0.0028000672,0.04063882,-0.034562495,-0.025818491,0.054232728,0.011647283,0.0006347513,0.05436445,0.00019324274,-0.005003445,0.13833034,-0.039745305,-0.11649192,-0.094674714,-0.008254517,-0.012230826,0.029023048,-0.009414645,-0.0045132306,0.024514774,-0.03658409,-0.044845846,-0.043829594,0.03627899,0.059420977,0.023917237,0.04849737,0.030418208,0.032115757,-0.07623427,0.044286925,0.05316203,-2.8824799e-08,0.067169614,-0.041277833,0.083525985,-0.061027426,-0.027784266,-0.004995139,0.032119624,0.0061175297,-0.040309973,0.04251904,-0.047284015,0.09414544,0.041419536,0.020729562,0.01998358,0.054267384,-0.036146864,0.07502093,-0.030446952,0.012184472,0.004830201,-0.06283064,-0.10511155,0.02823852,-0.015886592,-0.098270245,0.029569589,0.02660196,0.037219323,0.010178285,0.064957865,-0.054214414,0.10080867,-0.065469116,-0.06105182,0.06349203,-0.0446522,-0.069632106,-0.002733382,0.021608328,-0.0379237,-0.087905094,-0.0068161697,0.04479988,0.009964945,0.030953059,0.017491145,-0.033488,0.021049125,0.06341132,0.016704967,-0.050055988,0.005120105,-0.07840553,-0.06325257,-0.034520194,-0.06649377,-0.06297979,0.022043442,-0.05286638,0.022427665,0.115939915,0.14677957,-0.05696771 +1.1.1.238,"Acts on a number of bile acids, both in their free and conjugated forms.",384,1.0,0.05568152,-0.14225058,-0.02959304,-0.007851239,-0.028938621,0.0795035,0.044430178,0.021281961,0.089730576,-0.001814413,0.089942515,-0.031761285,-0.026276577,-0.015204438,-0.019327793,0.044586252,-0.05750138,-0.029485136,-0.08721891,-0.03752152,0.034195174,-0.0329992,0.017268235,0.0029223086,-0.03901279,0.010715608,0.11312118,-0.036389757,0.02910232,-0.08998735,-0.002547803,-0.010448734,0.062237423,-0.0064568645,-0.053145774,-0.019228086,-0.006903054,0.005504113,0.05278326,0.0046140463,0.075529225,-0.044912066,-0.021461653,-0.033263713,0.009628663,0.0004907425,0.051700726,0.026437247,0.025722247,0.025176754,-0.019267768,-0.020816457,-0.06459055,0.034732766,-0.0146380635,0.009050787,-0.09924568,-0.06494532,0.007990946,-0.008298835,-0.015082609,-0.036434684,0.07388903,0.017901134,-0.014774945,-0.039562207,0.040572602,-0.035755552,0.05829193,-0.06560789,-0.07222678,-0.01670553,-0.037325524,-0.031741638,-0.014144072,0.006388148,-0.04722324,-0.07547011,-0.005617342,-0.027104624,-0.06679017,-0.020328486,-0.004032354,0.086989954,0.051835127,-0.010556686,-0.011345427,-0.014724657,-0.045979366,0.034486875,-0.022962363,-0.043461196,0.022655489,-0.05831874,-0.016383266,-0.05536536,0.031961437,0.037188336,0.03469356,0.018009953,0.010164326,0.07856615,0.035129078,-0.07510381,-0.07374978,-0.016932838,-0.00184894,-0.0013828165,-0.020307284,-0.018836895,0.04777577,-0.08904501,0.09102227,-0.033128385,-0.081927985,0.14505996,-0.014300063,-0.10597084,-0.012274225,0.06483838,-0.007958163,0.0048684436,0.021322768,0.07309211,-0.051968012,-0.008784419,-0.042615253,-2.9908323e-33,0.04834673,0.0035085052,0.045656465,-0.014897619,-0.006240365,-0.037187148,-0.049232617,-0.04058482,0.058591742,-0.0108235,0.0641729,0.006705418,0.06581871,-0.025197582,-0.02542912,0.031006098,-0.020227542,0.0011954319,0.033874754,0.0035249584,-0.052398387,0.11202627,-0.035910867,-0.08318389,0.013652118,-0.036341764,-0.067274265,-0.017886018,-0.010108309,0.0018260189,0.047310106,-0.003947689,-0.0847276,0.14001608,0.010529922,0.08372259,-0.062690936,-0.0007399978,-0.022146005,0.026277404,0.03807617,-0.038034383,-0.024661278,0.012921524,0.023882274,-0.06536477,-0.05727524,0.026837882,0.04245033,0.054877028,0.07283756,-0.03145189,0.05292637,-0.025069201,0.02289863,-0.03598851,0.011347515,0.022111673,-0.044240147,0.06957424,0.023910616,0.07752362,-0.09968409,0.05045024,-0.07333951,-0.02967854,-0.12381172,-0.027734436,0.024453187,-0.002869579,-0.04345659,0.012154509,0.06328428,-0.010525077,-0.03235528,0.017354148,-0.05770057,-0.018169632,-0.022301154,0.07755441,-0.02265293,-0.06588054,-0.0026388883,-0.019392956,-0.0691871,0.06743363,-0.018587062,-0.11702849,-0.04147249,-0.019546648,-0.033832673,0.041345917,-0.057932217,-0.018411586,0.10068973,-9.935453e-34,-0.03623232,-0.055604085,-0.053227652,0.0637966,-0.006806744,0.034817062,0.0012559103,0.0011413115,0.01639132,-0.033738617,0.0044078734,-0.0076115537,-0.015244184,-0.04043846,0.057973094,-0.0042932797,0.052548308,0.11039872,-0.005520953,-0.020536551,-0.09081531,0.11915166,0.07213519,0.09967779,-0.051471718,0.07308832,0.056706976,-0.057016283,0.061815463,0.15316643,-0.02590021,0.008517471,-0.038801596,0.013800736,-0.04098103,-0.044937614,-0.01632426,-0.0046107518,0.009158309,-0.041890886,-0.016480962,-0.021526981,0.15184984,0.0824971,0.0009822324,0.046766844,0.015381323,0.03246065,-0.037322816,-0.039671957,0.033086702,-0.005562959,-0.020421857,0.018158559,0.060655564,0.13889809,-0.02191205,-0.04572104,0.0054515162,-0.11308404,-0.12453299,0.017990556,0.004557378,-0.098837085,-0.0005006887,-0.019119773,-0.01624604,-0.025852606,0.049031697,-0.019861478,0.024178017,0.05682057,-0.022622703,0.012797431,-0.0012139437,0.006840826,-0.03393,-0.059266903,0.019929787,-0.06258348,-0.061571036,0.0035591342,-0.013882501,-0.05744323,0.021017183,-0.062626675,-0.105915636,0.057788815,0.0070710876,0.023997366,0.017510714,0.0328933,-0.04554399,-0.014189459,0.0028032544,-2.2972314e-08,0.08416971,-0.084238194,0.00455749,0.058641817,-0.00046642145,0.023058644,-0.022300286,-0.03617338,0.03314819,0.016405283,-0.009096626,0.13961147,0.019965239,0.008643232,0.052765787,0.06987831,-0.045025986,-0.012358114,-0.06200722,-0.05925614,-0.12210848,-0.032044087,-0.037888635,0.024999522,-0.04453571,-0.057501454,0.029122869,0.02388111,-0.04465564,0.0014343822,0.08654828,0.00038811422,-0.08036846,-0.04453316,-0.009694933,0.013099096,0.034119055,-0.020946521,0.02320195,0.04204434,0.008619267,0.0205941,-0.07992323,0.024174782,0.005201287,-0.009107111,-0.057539474,0.045340937,-0.0014112937,0.04319236,-0.02830209,0.007705085,0.06474158,0.05234133,-0.059558675,0.07870489,0.09003358,-0.07018937,0.06076678,0.018795602,0.042914663,0.07051272,0.14991952,0.0012303842 +1.1.1.239,Also acts on other 17beta-hydroxysteroids and on the 3alpha-hydroxy group of pregnanes and bile acids. Different from EC 1.1.1.50 3alpha-hydroxysteroid dehydrogenase (Si-specific) or EC 1.1.1.213 3alpha-hydroxysteroid dehydrogenase (Re-specific).,384,1.0,-0.0011587609,-0.053920366,-0.01987989,-0.09582583,0.022781018,0.036449973,-0.011675218,0.006848358,0.027613832,-0.052138727,0.047159065,-0.041748397,-0.11196294,-0.05556906,-0.0022830372,0.023776677,0.010564846,0.013226619,0.001244942,-0.046810444,0.041266818,-0.02247985,-0.00025510034,0.001656359,0.012083848,-0.031832498,0.052948654,0.10138811,-0.06598655,-0.07384614,0.043424398,0.02774817,0.08890041,-0.00758835,-0.0795734,0.06410893,-0.08139417,-0.07314122,0.0340063,0.11449267,0.096691914,-0.039361987,0.0007435879,-0.018038234,-0.025530003,-0.099195234,-0.07914059,0.09857165,-0.026641916,0.053405963,0.036895327,-0.05711566,0.010972397,0.07431004,0.021002159,-0.016848076,-0.08552668,0.010616088,-0.0041181566,0.036018353,-0.051977564,-0.009643261,0.05494714,0.019832456,0.03965123,0.010919846,0.07880603,-0.12402829,-0.007459032,-0.0778977,-0.05416035,-0.04405473,0.030791158,0.07248948,-0.052393157,0.047202673,-0.046132393,-0.0045148246,0.033259165,-0.0843004,-0.071520366,0.0037740746,0.0069006537,0.055642426,0.04177103,0.009422318,0.0027217714,-0.015568204,-0.043254245,0.049185008,-0.009720297,-0.07620289,0.024513453,0.055900104,0.030976001,0.033090085,0.010841502,-0.03553302,0.03712673,-0.049689673,-0.017336804,0.12871161,-0.037081007,0.026347077,-0.074747436,0.0224058,-0.0058467714,0.0377707,-0.064147875,-0.035260387,-0.0062598893,-0.10031902,0.08390517,-0.02637896,-0.065126106,0.0747914,0.043467652,-0.06254408,0.029425701,-0.030924844,-0.004154347,-0.048254225,0.035509024,0.01794835,-0.018259175,0.07611026,-0.08226395,1.5615868e-33,0.08971824,-0.0358389,0.004344199,-0.03698144,-0.017869769,0.08068974,-0.0618246,0.05508138,-0.04168285,-0.045691036,-0.036615696,0.041923173,0.106416024,-0.024659447,-0.014739433,-0.012155174,0.02497596,0.00063984114,0.044289533,0.012597118,-0.04931129,0.055027027,-0.09506116,-0.093755364,-0.031707425,0.048675336,-0.044506688,0.064476475,0.033514254,0.003584564,-0.055579077,-0.060433615,-0.039500576,0.056723014,-0.054285765,0.06323712,-0.039293777,-0.04928054,0.017720893,0.051874846,0.03812721,0.022115164,0.061529014,-0.07951001,0.045044422,-0.018373488,-0.055140804,0.03920374,0.12075095,0.03128569,0.014713697,-0.0016375722,0.06054981,-0.07850011,0.011338209,0.01431849,-0.06255464,0.03552802,-0.007288704,0.07892787,-0.029737866,0.07755594,-0.02420368,0.031554397,-0.023015838,-0.018217256,-0.043581817,-0.04166128,-0.07210462,0.0166449,-0.04674465,0.0036838406,0.12712689,-0.04383546,0.007081107,0.055702783,-0.038079392,0.021330258,0.0061020176,0.0042688684,-0.057147924,0.010541104,0.014176734,-0.039037544,-0.06111816,0.070612304,-0.03193695,0.0018187849,0.060260892,0.023925345,0.035808213,-0.024776928,-0.08064874,-0.005615223,0.032738563,-3.417217e-33,0.002084686,-0.026142808,-0.04256911,-0.07747485,-0.0004195382,0.09675379,0.07904051,-0.04089001,0.003367133,0.012715591,0.09435161,-0.031215688,-0.05309426,-0.18096313,0.075592265,-0.015752576,-0.037930854,0.04590531,-0.060396522,0.009808057,0.005604213,0.0570057,-0.037091207,0.14144021,-0.001846812,0.004461646,0.053009357,0.0010161644,0.018770825,0.03160943,-0.061223816,-0.013287662,-0.043443665,0.04854768,0.058013357,-0.013018049,-0.09678661,0.019778764,0.038520396,-0.061316747,-0.055914246,-0.005153608,0.03735303,0.063217305,0.054005343,0.13055936,0.025737861,0.017356249,0.017318105,0.036975276,-0.07765513,-0.029917344,-0.019475147,0.039312594,-0.000253756,0.052454006,0.008103803,-0.025300665,-0.014243659,-0.040121302,0.036124896,-0.011560803,0.02293819,-0.0038888261,-0.06604049,-0.01705382,-0.04732799,-0.011126675,0.026035065,0.054540105,0.048750564,-0.021831378,-0.00680742,-0.0036800872,-0.025682371,-0.110725746,-0.009533576,-0.050260868,-0.034572717,-0.014823887,0.04001604,0.05444094,-0.03437007,-0.011085278,0.023462946,-0.00081119896,-0.03516463,0.03102903,0.0054664374,0.036067087,-0.03819992,0.017902756,-0.15258119,-0.019081827,-0.0008878906,-3.5697358e-08,0.06038682,-0.04981049,0.027567655,0.016574154,0.020686843,-0.033379532,-0.016042715,0.029906392,0.08420435,-0.005268928,-0.010173226,0.11721677,0.036169544,-0.025137886,0.07493113,-0.046440013,0.009322645,0.023500726,-0.010595833,0.011932485,-0.0634124,-0.014367343,-0.04231001,-0.006631944,-0.008906653,-0.030270305,0.016097082,0.043388132,0.044493902,0.0030377596,0.06317737,-0.0021464585,0.04969108,-0.005164842,-0.0043374025,0.023134459,-0.0031136693,0.03771605,0.023358198,0.032313332,0.0020415687,-0.13573302,-0.035988186,0.031018639,0.02772783,-0.01086621,-0.030447174,0.006237955,-0.003914212,0.007551575,-0.041994635,-0.03777806,0.03786128,-0.023877576,-0.025719684,0.01030869,-0.04514126,-0.123164296,0.051935907,0.004080859,0.05526136,0.00045286727,0.21106753,0.024286563 +1.1.1.240,"Also acts on N-acetylgalactosamine and, more slowly, on N-acetylmannosamine. Anomeric specificity was tested with N-acetyl-D-glucosamine, and it was shown that the enzyme is specific for the alpha anomer.",384,1.0,-0.02983469,-0.1075055,-0.095023036,-0.036054004,0.012295216,0.0055094855,0.012137508,0.019658258,0.012347416,0.06878175,0.008923677,0.064606234,-0.08345966,0.12551074,-0.10762005,0.07981352,-0.026191825,-0.057235446,0.060685538,-0.07025876,0.0027061014,-0.016051803,-0.0133585185,-0.034301095,-0.010326479,-0.0297958,-0.0059696967,-0.010179213,-0.010011245,-0.09162858,0.00019985597,0.016547477,0.07660459,0.046117585,0.06421265,0.055136047,-0.091911465,-0.021203186,0.014649925,0.053101677,0.058287088,-0.0024679888,-0.008518128,0.030612562,-0.046931673,-0.016332095,-0.061205544,0.024073195,0.024036882,0.08845311,0.0432845,-0.034739096,0.006124155,-0.029644703,-0.046851993,0.050856106,-0.087845646,0.0025910947,-0.038242742,0.06425841,-0.013830375,0.030246316,-0.026099166,-0.0056853727,0.058075856,0.02094199,0.10047957,-0.109153956,-0.08022071,-0.004186481,0.038564984,-0.06388865,0.039516464,-0.03999845,0.04578886,-0.031008359,-0.046089206,-0.013380933,0.0037057581,-0.03330612,-0.024051882,0.018070497,0.03696735,0.06951502,0.03229415,0.040347178,-0.0071191685,-0.004951902,0.009615591,0.0583824,-0.010457328,-0.06773341,-0.016420778,-0.05434056,0.0031629505,-0.02786447,0.04307887,-0.0019519913,-0.009190514,-0.018739915,0.012213075,0.020810788,-0.025419889,-0.007721881,-0.09741469,0.049599394,0.019125389,-0.029421339,0.07515849,0.09195179,-0.023904847,0.036315087,0.06099047,0.030673202,-0.045717195,0.051131006,-0.06759439,-0.0033999486,0.007212132,-0.029246613,0.05084056,-0.040264565,0.0134412935,0.07860272,0.015472256,0.12905067,-0.05742846,9.254482e-34,0.0432432,0.04041291,-0.007338537,-0.016197411,-0.027346,0.067031,-0.055295177,0.029552484,0.043299273,-0.0756815,-0.05263822,-0.029520407,0.08912538,0.025109,0.012663867,-0.0028447486,0.013703599,-0.011884325,-0.013658306,0.0024964372,0.010636794,0.046895675,-0.101182155,0.02329887,-0.05681463,-0.04129463,-0.06957164,0.047916323,0.022405166,-0.027723847,-0.024946893,-0.012210086,-0.08733733,0.069235004,0.013859924,0.032683965,-0.005317902,0.0040724897,0.04310105,0.016458767,-0.003709481,0.06338077,0.019587312,-0.018792085,-0.007772222,-0.07803159,-0.06614946,0.00029615057,-0.021446504,0.037364773,0.0074648694,-0.029675284,0.035699636,-0.052079305,-0.040085293,0.06546678,-0.098558374,-0.08140021,0.035561696,0.057980713,0.031668283,-0.020521399,0.03455591,-0.07020216,-0.061856356,0.019897653,-0.0071261544,-0.10023962,0.00555554,0.029448286,-0.0390954,-0.00073924434,0.11457768,0.048514593,0.013666335,-0.0036385786,-0.00030590096,0.11209523,0.023947561,-0.07537776,-0.016430128,-0.038523093,0.06520014,0.055218477,-0.062277466,-0.03778862,0.075562954,-0.059655946,0.016404387,0.019802952,0.06944031,-0.08771323,-0.12274518,-0.005332548,0.031284876,-2.0829416e-33,0.04777507,-0.093691826,0.044099286,-0.023215171,-0.06279163,0.06824138,0.08564123,-0.004374027,0.0058163633,-0.020141665,0.099395305,0.030203985,-0.058302052,-0.08409898,0.029713789,0.031950843,0.009569908,0.11876966,-0.0011380349,0.053323667,-0.027538761,0.04575498,-0.01569242,-0.013925049,0.035892613,-0.0017966073,-0.015570703,-0.026106222,0.0031814342,0.029300557,-0.047362603,0.027901601,-0.043096244,-0.07913395,0.042962708,0.05523417,0.015567199,-0.01305167,-0.10913099,-0.025053412,0.070768364,0.08348511,0.032259904,0.07530962,0.06464179,0.055979423,-0.09254985,0.0057682255,-0.049048007,0.013277124,0.030186052,0.00149125,0.07113164,-0.01755164,-0.011596953,0.06952759,0.032245114,-0.039186817,-0.05820843,0.030083308,-0.021701414,0.047297563,-0.04760206,0.003924284,0.029134162,-0.06323477,-0.039688922,0.045429453,0.0682326,-0.0017464033,-0.047478978,0.0066678217,0.078665465,0.09915085,-0.027529035,-0.11697326,-0.036320068,-0.121000275,0.007929609,-0.06764851,-0.05443026,0.04352989,-0.0025384186,-0.0095307175,-0.044739503,0.0328489,0.06392076,0.0340307,0.0070072636,0.03574168,0.026784856,-0.030977273,-0.09668229,0.021001687,0.056425225,-3.4459195e-08,0.07552069,-0.025668126,0.030485181,-0.08070144,-0.010969166,-0.0016714924,0.036383796,0.009692882,0.031624816,-0.05445747,-0.0118420785,0.11473486,0.037242144,0.030928219,-0.0070371004,0.018120332,0.045234717,0.0005582594,-0.043708272,0.031327058,-0.10723816,-0.008482211,-0.05031175,-0.015500031,-0.02948098,-0.014960203,0.022777632,0.087183416,-0.028441753,-0.0022601117,-0.03280603,0.03406667,-0.012003103,-0.14088379,0.01773985,0.05019287,0.063051306,-0.0470816,0.039786886,0.031670034,-0.039350837,-0.019611359,-0.0412964,0.06285487,0.06397233,-0.08130549,-0.02575754,-0.1263228,0.04202272,-0.0028171644,0.03688117,0.0109058535,-0.024263194,-0.09568823,-0.06277686,-0.09548136,-0.018362487,-0.044933792,0.054944683,-0.08444096,0.018672053,-0.0027088304,0.11119082,-0.025709799 +1.1.1.245,Also oxidizes some other alicyclic alcohols and diols.,384,0.99999994,-0.022841329,-0.038653687,-0.008932565,0.1055436,0.058638755,-0.0622469,-0.026702318,0.03275033,0.053699996,-0.069065005,0.0066673984,0.10854076,-0.042286653,0.07614631,-0.012279056,0.05289907,-0.03335216,0.076019645,-0.04462196,-0.024715288,0.03781574,-0.022476798,0.03815847,0.030708246,-0.019470496,0.048053473,0.005353679,0.056607705,0.022553103,-0.09342204,0.075625174,0.09876002,0.024764946,-0.06865779,-0.025802793,0.022106808,-0.016286092,0.057517406,0.015196027,-0.03195409,0.0021923482,-0.004436046,0.01566119,0.027574081,-0.0045235353,-0.014412801,-0.028412601,0.022659939,0.012546103,0.032979563,-0.010790088,0.038586613,-0.033365272,0.0077678855,0.06443627,-0.022717172,-0.076884784,0.03397335,-0.0077385576,0.008338061,-0.014637668,0.03548711,-0.06423255,0.07797163,-0.05753708,-0.017409224,0.067892626,0.0034330196,-0.026570193,-0.019470086,-0.027834227,-0.09384399,0.045416083,0.010224433,0.016248368,0.0060898997,0.007860315,-0.08082201,-0.012736178,0.04341366,-0.022433423,0.032484956,0.026419718,0.070739545,0.099206224,-0.008585257,-0.037448153,-0.1789078,-0.09832681,0.034658074,0.010412925,0.018463729,0.023850081,-0.05062636,0.012801676,0.009139134,0.038037732,0.04384252,-0.072569974,0.019290494,-0.02276524,0.06499545,-0.057877377,-0.093522444,-0.036608376,-0.0037261588,0.050951984,0.040189777,0.027432872,0.020952204,0.0055554323,0.02113901,0.018631702,-0.008867824,-0.05297086,0.080089375,0.06991158,0.021629421,-0.06839805,-0.02591339,-0.034589216,-0.035244316,0.0024871144,-0.009654094,-0.04548948,-0.019117119,0.041412402,7.5596115e-34,-0.008993973,-0.025440749,-0.00062938104,0.006318833,0.04086368,-0.038546316,-0.07980978,0.0018493567,0.068186216,-0.018217802,-0.0071730255,0.0018355475,0.0050931918,0.02217153,0.020075163,-0.03509084,-0.031931378,0.048645634,0.022157075,-0.016874075,-0.0113086505,-0.042821247,-0.03778773,0.032340888,-0.0043679206,0.04300871,0.057453465,-0.0036063115,-0.019191235,-0.014934061,0.020946914,0.038031187,-0.06668085,0.047223568,-0.09572501,0.1468866,-0.10688496,-0.022631489,-0.021823201,0.056419607,-0.004995556,0.04076031,-0.04096364,-0.0013877131,0.03545069,-0.054958884,-0.09468693,0.10286376,0.017779635,0.020738432,0.00435164,0.008133812,0.042353287,-0.002042021,-0.030184627,0.05031803,0.016826179,-0.0877842,0.026708497,0.044094596,-0.089703776,0.052852634,-0.08683417,-0.019824838,-0.03307809,0.009294047,-0.04454846,-0.0388449,-0.061249733,-0.001606298,-0.08252885,0.024379384,0.09798591,0.007020939,-0.051265035,0.009143462,-0.044642083,0.00069949427,0.087648764,0.017058002,0.034359396,-0.11099921,0.017889777,-0.0108440565,-0.01938002,-0.028161151,-0.015527964,-0.012424808,0.021212185,-0.016387142,0.06492343,-0.09141034,-0.052119106,-0.046468653,0.042264026,-2.9112697e-33,0.07029076,-0.07589504,0.007806103,0.020606743,0.019812347,-0.029343631,-0.00013995792,-0.014745146,-0.031181052,-0.09148539,0.0065427534,-0.012643263,-0.054248836,-0.031304523,0.044120554,0.03779338,0.03566695,0.0904881,-0.044077907,-0.011607871,0.011322454,0.12785225,0.06476719,0.0027283812,0.069635004,-0.025147827,-0.056107294,-0.053286865,0.06771101,0.06322142,0.022511097,-0.010348959,-0.045404155,-0.076896936,-0.02907645,0.030113462,-0.07341115,-0.0069276206,-0.08822643,-0.01895093,0.016283687,0.0018772132,0.04303916,0.028887436,0.049681045,0.07073988,-0.053396102,-0.0889362,0.012939577,0.013290568,0.106502034,0.017825447,-0.087312154,0.07348472,0.066364855,0.019005267,-0.015689196,-0.07822099,-0.017349068,0.001418116,-0.08598516,0.069070056,0.0034737575,-0.048237734,-0.01720274,-0.038627356,-0.096983135,0.0649583,0.030122712,-0.03308838,0.13000566,-0.024909528,0.0142456405,-0.0065795365,-0.07442979,-0.050335992,-0.018380288,-0.022568911,-0.055151008,0.018011838,-0.039803613,-0.0048735593,-0.020118255,-0.023552477,-0.071451716,-0.07504453,0.010999656,0.022715522,-0.015225789,0.07551462,-0.0226354,0.0032526492,0.008279594,0.05835041,0.021793777,-2.1704517e-08,-0.06698583,-0.0087844785,0.07391969,0.042880047,-0.107524976,0.04025692,0.11354008,0.10447983,-0.057075825,-0.08085379,0.03396213,0.09867301,0.067489855,0.0159279,0.089658394,-0.013679956,-0.009911783,-0.011682702,-0.009724556,-0.059975065,-0.09342071,-0.057070926,0.06397122,0.061030164,-0.045523226,-0.05297494,0.068569764,-0.045311518,0.06465807,-0.032302048,-0.037908453,0.033291403,0.0038098318,-0.019685194,0.016628567,-0.019631378,0.0053941174,-0.041197762,-0.052179217,0.03375885,-0.08362356,-0.06600876,-0.10068811,0.055332735,0.038582556,-0.035773415,-0.0052239737,0.07761939,-0.043170128,0.010840896,0.09248898,0.02831297,0.01578199,-0.050010204,-0.060533576,0.0599153,0.025757084,-0.022664648,0.025881821,-0.054744195,0.017422806,0.01496432,0.20199715,-0.019296281 +1.1.1.246,The reaction is catalysed in the opposite direction to that shown. This plant enzyme catalyses the penultimate step in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.,384,1.0,-0.021151848,0.03459484,-0.14899406,0.05503575,0.023872783,0.06576731,-0.08850104,0.016179388,0.04691243,-0.022967495,0.06304038,0.004358994,-0.07613704,-0.09304959,-0.080405675,0.04881803,-0.12340503,0.022636559,0.043483157,0.012698286,0.031581666,-0.0067400765,-0.007863276,0.052703984,-0.01435246,-0.011555148,-0.0046473783,0.02197292,-0.015832046,-0.011751146,-0.055788744,-0.007644528,0.0141188605,-0.03416417,-0.004786473,0.07825444,-0.07125894,-0.020010414,0.08503538,-0.035864066,0.09154291,-0.04163433,-0.009523055,-0.0113896085,-0.01216736,-0.046067245,-0.014753431,-0.0006656861,0.073664345,-0.039504074,-0.075680554,-0.006980847,-0.05720038,-0.011235446,0.03826572,0.0022064783,0.03597674,0.05195077,0.07123241,-0.01241726,0.057707544,0.0033700683,-0.020065634,-0.008899903,0.038131706,-0.08209385,-0.06628508,-0.051195614,0.055556748,-0.04698017,0.0031682523,-0.065420926,0.05624325,-0.014221678,0.031911843,0.07803404,-0.057201218,0.051206853,-0.0048923916,0.011344162,0.04434348,0.011370651,-0.012727288,0.10297478,-0.009325499,0.019421937,-0.020825682,0.012028444,0.08196481,-0.026863832,0.10848756,0.022829762,-0.05007589,0.024722137,-0.026916074,0.010188804,0.059956264,-0.05925501,-0.01262386,-0.01314998,-0.0070263003,0.020177824,-0.118096955,-0.10421758,0.009949616,0.051772546,-0.032331426,0.0464337,0.058497753,-0.033501774,-0.030924482,-0.046871074,0.024567537,0.008954872,-0.018843124,0.071461394,-0.020208964,-0.03297457,-0.012792965,-0.00012872426,0.04195581,-0.015255593,-0.019082282,0.04965894,-0.040699765,-0.004832476,-0.07468676,2.8286056e-33,0.048602954,0.05851298,-0.011753564,-0.056353647,0.0650383,-0.041446935,-0.029811166,-0.101371415,0.01659557,-0.04397269,-0.103417486,-0.09512096,-0.038549595,0.013720577,-0.08924554,-0.10965162,-0.055816744,-0.0036494464,0.034048572,0.047434174,-0.010633631,0.015582606,-0.116443984,0.011641082,0.009043746,0.093203954,-0.04499677,-0.037776034,0.008610629,-0.0034442092,0.011095229,-0.044985887,-0.067882836,-0.046223197,0.016431522,-0.022778295,-0.017432988,-0.06468552,-0.023463931,0.06247269,-0.055529825,-0.0032342477,-0.014896491,0.008193273,0.076474875,0.021279417,-0.042708658,0.08618676,0.056966864,0.025646547,0.023734065,-0.028704232,0.10851316,0.03616948,-0.03836165,-0.007579629,0.0042647296,0.014645192,0.035572823,0.052255485,0.045246013,-0.019199805,0.009323036,0.0016874349,-0.027500456,0.031059362,-0.06613176,-0.017369034,0.069890685,0.080152184,-0.08328786,0.0349614,-0.006507918,0.03694498,-0.006972228,0.006103069,-0.04079457,0.016570713,-0.014569115,-0.029093962,-0.048350055,0.018517038,0.0044324957,0.036103923,0.015848082,0.02684518,-0.094326,-0.034963146,-0.012957702,0.08464479,0.043203,0.008000014,-0.023349855,0.017592516,-0.022299243,-3.7262348e-33,0.07687384,-0.036970306,0.0078014787,-0.09733359,-0.12633033,0.014293511,-0.09954159,-0.05399033,0.030126551,0.010175374,0.018805059,-0.046433296,0.023878999,0.04000125,-0.020071277,0.13598533,0.067725785,0.1274698,0.005857362,-0.050258555,-0.09333002,0.02301121,-0.03107605,0.06529032,0.06355325,-0.0032095278,0.07419565,0.059212912,0.048196822,0.0067623826,0.029874127,-0.02501272,-0.03828363,0.042255614,-0.044149898,0.14869465,-0.061664276,0.019294482,0.08170381,0.08946598,0.075282976,-0.015750876,-0.0015417394,0.011222775,-0.0026321884,-0.028364303,-0.021826077,0.07929925,-0.025000121,-0.0772207,0.09267392,0.033353522,0.03779995,-0.001712003,-0.009546834,0.040828798,0.072774455,-0.049792226,0.008980835,-0.05065936,-0.019341419,-0.05009917,-0.016814329,-0.030251732,-0.010381738,0.07760008,0.011656241,0.01695821,0.048504896,-0.005193513,0.10990503,0.0587821,0.007861516,0.06180581,-0.0016111536,0.018091146,-7.659991e-05,-0.037596263,0.025150793,-0.04476764,-0.023132052,0.0356238,0.08888953,-0.11462935,-0.07839529,0.0034806435,0.0244403,0.08830172,-0.023850616,0.020184696,0.014083782,-0.008430991,0.0030393777,-0.013042449,0.09446752,-3.044305e-08,0.054554194,-0.07501443,0.02153901,-0.040177442,-0.015815245,0.033555966,0.007812942,0.009719313,0.008472125,-0.049834423,-0.046890598,0.047449954,-0.011214861,-0.002357525,0.024257712,0.08111563,-0.009322621,0.022534376,-0.027802473,0.022085773,-0.12264752,-0.026921334,-0.103373624,0.031190902,-0.057084158,-0.050244533,0.034103185,0.037822507,0.019723335,0.017846208,0.05297834,0.034591325,-0.072758906,-0.039551247,-0.06382484,0.041354537,-0.050090488,-0.07694668,0.04057416,-0.0008883333,-0.029113093,-0.03228918,-0.025236651,-0.040734783,-0.061728515,-0.010493108,0.016347833,0.02364524,0.0034735089,-0.04373672,0.057667963,-0.019740244,0.048842065,-0.053179417,-0.050452005,-0.008688545,0.032278705,0.037667826,-0.038878508,-0.009952268,-0.053832553,0.0544771,0.21501261,-0.035533704 +1.1.1.247,"Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum.",384,1.0,-0.008645623,-0.034193262,-0.055573255,0.047211614,-0.01485468,0.029068364,-0.047508806,0.00071053713,-0.011792612,0.0055892398,0.022159085,0.0674917,-0.058405105,-0.019215088,-0.03831086,0.055612803,-0.092463166,0.037917938,0.037515827,0.033117652,0.089666806,-0.020510819,0.009660172,0.038435187,0.0071242834,0.16405155,0.018526435,0.037938695,0.025835404,-0.047717165,0.09808052,0.041710347,0.03386845,0.031054985,-0.072821416,0.0020810817,-0.04299867,-0.0075330664,0.107390165,0.055104412,-0.040018808,0.023479145,-0.031400867,0.00586375,-0.020482782,-0.039951462,-0.005736541,-0.023002356,-0.057482004,-0.11973945,0.054624084,0.0064529036,-0.049903184,0.030053794,0.021419587,-0.07788392,0.036487993,-0.0081338035,0.020415995,0.047635943,0.006023142,0.12923418,0.014814625,-0.016825495,0.011143202,-0.0008331511,-0.06351372,0.009324842,-0.0006756628,-0.012152827,0.022274781,-0.05114738,0.031641383,0.033814423,-0.0017460614,0.02255398,-0.013963405,0.0018049582,-0.0010059477,0.00936163,0.040592793,0.012499678,0.013209808,0.13555141,0.019758325,0.043964244,-0.008042935,0.049198758,0.038380854,0.010646773,0.07302175,0.018091507,-0.024060534,0.04385836,-0.068249315,-0.07609436,0.06847828,-0.033324674,-0.012939639,0.0067806323,-0.022323024,0.04377649,-0.12247633,-0.123748325,-0.051884543,0.0578786,0.056178503,0.031848073,0.02883296,-0.010997159,-0.05467477,-0.03107421,-0.012676459,0.03099033,-0.06792782,0.06747,0.068796635,0.013323718,-0.0032307485,-0.018740129,0.0233876,-0.004802993,-0.07575579,0.050618336,-0.04205083,-0.002947494,-0.069997266,1.1874168e-33,0.007176642,0.027727831,0.0076502017,-0.009537742,0.015919385,-0.03008495,0.0007445093,-0.020114552,0.016284397,-0.037080303,-0.051956527,-0.06946907,-0.032410253,0.085757256,-0.07483071,-0.095093034,-0.053781226,-0.037163362,0.034971558,-0.06264461,-0.07020028,-0.010122926,-0.061461896,-0.010151829,-0.026927141,0.099427484,-0.03423017,-0.038193174,0.09690988,-0.025997493,0.030075898,-0.011670001,-0.05801875,-0.035554133,-0.007526509,0.05349567,-0.007154804,-0.036947504,-0.1206622,0.042982038,-0.016723657,0.017582878,0.016566304,-0.02137065,0.051378142,-0.05244504,-0.049019925,0.05483685,0.063100934,0.037450407,0.066575676,-0.032626178,-0.022031264,-0.014430924,-0.069849,0.0071774395,-0.06440486,-0.06824419,0.07613755,0.0896222,0.029804569,-0.04570043,0.0035717955,-0.017141484,0.017974284,0.03971881,-0.027620343,-0.083662376,-0.0093752025,0.080921695,-0.07968074,0.015500177,0.020553982,0.025555205,0.009651479,0.080878325,-0.024206677,0.03273245,0.004765774,-0.05632988,-0.012190238,-0.086804554,-0.011829425,0.0120476475,-0.011191391,0.03063844,-0.0025132003,-0.06496789,-0.06438977,0.10731402,-0.062268663,-0.109265536,-0.030441307,-0.09618302,0.011135464,-2.0860582e-33,0.04505499,-0.059256576,-0.010276877,-0.010055889,-0.041966457,0.025875557,-0.010579292,-0.02477844,0.017035628,0.056248244,-0.021397432,-0.026079116,0.12740226,-0.04359015,0.04146385,-0.009018025,0.003982435,0.089547575,0.020953061,0.02748919,-0.029523248,0.12853828,-0.059969388,-0.008700812,-0.008851387,0.047747955,-0.037367966,0.11308553,0.122823894,-0.047179483,0.06698538,-0.046356153,-0.031501304,-0.077317305,-0.036136113,0.16868003,0.018591177,0.016766455,0.0015850542,0.004504647,-0.09362171,-0.031283166,0.0063646217,0.10345034,0.013619888,0.02184479,-0.061988555,0.03215605,0.11328535,-0.022168495,0.059426345,0.04929528,-0.048050053,0.0013379187,0.034574486,0.00370571,-0.025040887,-0.10097662,-0.045255672,0.0069047804,0.004190247,-0.004983822,0.034648627,-0.07889272,0.013099431,-0.032494,-0.036192514,0.05160892,0.009058679,-0.027838781,0.056159385,0.041162476,0.017864773,0.042052533,-0.018960427,-0.078776844,-0.088801526,-0.070270166,-0.011318797,0.011046313,0.0319999,-0.03845141,0.004185806,-0.025073199,-0.0073435605,-0.012805574,0.040927116,0.08036148,-0.04313591,-0.015544165,0.019940833,-0.010691927,0.0067263786,0.030345803,0.028891217,-2.5310195e-08,-0.014913465,-0.08039779,0.032607652,0.0107363155,-0.042652953,0.026669312,0.044331554,0.011689848,-0.023737092,-0.11049165,0.050420724,0.03304584,0.012663163,0.03930821,0.032529898,0.021705365,-0.08417091,0.00955548,-0.015663752,0.009117202,-0.04610311,-0.005899658,-0.10496117,-0.051618643,0.029499775,-0.043575414,0.06489797,0.060498796,-0.03439413,0.04095911,0.13896695,0.035603777,0.058343947,-0.021465896,-0.026431972,-0.018252494,-0.009056795,-0.050833493,0.01553693,-0.050630547,0.04554345,-0.025354018,-0.11288693,0.02832156,-0.00984262,-0.03833229,0.033268012,-0.023888908,-0.05897529,0.0009598382,0.07663955,0.042373933,-0.012648648,-0.020234004,-0.00025590407,-0.02226479,-0.04588109,-0.008113486,0.0049392404,-0.051429413,-0.035767913,0.009787087,0.20593314,0.03444813 +1.1.1.248,"Catalyses the reversible reduction of salutaridine to salutaridinol, which is a direct precursor of morphinan alkaloids in the poppy plant.",384,1.0,0.0009612274,0.06353182,0.023129087,0.065584406,0.021496084,0.08215999,0.0027705578,-0.0017355646,0.060321476,0.023964873,0.018085014,0.032738674,-0.014808816,-0.022816295,-0.055360604,0.071182676,-0.09558929,0.10850794,-0.012313399,-0.002065828,0.081791244,0.0025933678,0.028781198,0.044098902,0.05476402,0.07004423,-0.004819827,0.010400978,-0.015237938,-0.115623266,0.11002373,0.016238727,-0.0014236983,-0.05632795,-0.048382893,0.003895107,-0.040376183,0.0076484974,0.11038152,0.047325995,-0.006200433,-0.03943534,-0.060343053,-0.026046945,-0.018084269,0.0023750893,-0.00049555686,-0.013698581,0.007326927,-0.05850801,0.048895787,-0.03167787,-0.042442083,0.04206574,0.0013074378,-0.06378607,-0.04842524,0.006154396,0.0222852,0.016731285,-0.045673553,0.041283622,-0.03159816,-0.061392132,-0.06043783,-0.059291758,0.0095162885,-0.023506103,0.08597687,-0.03935769,0.016377056,-0.035085298,0.056284696,-0.028607603,0.052795723,0.009674024,0.015807096,-0.005725198,-0.08418367,-0.052955143,0.084765226,0.036092028,-0.060163274,0.10829177,0.038451016,-0.008165547,-0.0067250603,0.005440397,0.065784834,0.0022369502,0.059342746,0.014427773,0.03757142,0.0163678,-0.015428117,0.019975135,0.017504122,-0.04628568,-0.010497046,0.021577965,0.02048512,0.03972352,-0.123197965,-0.1365594,-0.038784947,0.017708568,-0.036135845,-0.01663073,-0.04898421,-0.059349973,0.003075259,-0.03842362,0.01627859,0.048371922,-0.066867195,0.045531243,0.065622084,-0.05220936,-0.08803859,-0.068793274,-0.034284107,-0.029867264,0.024071373,0.02128818,-0.045791678,0.037103686,-0.04024835,2.9740826e-33,0.014936209,0.07583249,-0.05767136,0.015503472,0.0098977415,-0.04638815,0.010315872,0.0025233102,0.0036623615,-0.11179308,-0.06441964,-0.01561972,-0.07148626,0.028010357,-0.02190016,-0.103766195,-0.0009927882,0.035584904,0.005179671,-0.102184385,-0.074275434,0.041568536,-0.059341915,-0.049933214,-0.03530781,0.052117623,-0.035330147,-0.044529844,0.031688403,-0.017884025,0.060016025,0.05540845,-0.036059387,0.05284463,0.056708343,0.0272175,-0.007823853,-0.06199184,-0.0038426025,0.07857586,-0.03969936,0.047868144,0.011805764,0.06247862,0.065111,0.014380999,-0.052398108,0.08551062,0.050338577,0.046690896,0.039654385,0.0043576197,0.037287887,0.004884469,-0.058098327,0.000567433,-0.036180917,-0.07134021,0.05364467,0.019411251,-0.01682586,0.065085374,-0.09602084,0.0047336672,-0.010207914,-0.05384898,-0.04009935,-0.0141747445,0.008737558,0.090806104,-0.041160833,0.00092138525,-0.042567294,0.08166292,0.04919998,-0.006337499,-0.037245195,0.0629695,0.036291417,-0.0026662245,-0.020047018,-0.046277434,-0.05988902,-0.029918922,0.00882312,0.006211984,0.03272776,-0.029325534,-0.033448312,0.019089732,-0.033769157,-0.0059418697,-0.05862615,-0.05248111,0.0028391285,-2.5812295e-33,0.082410425,-0.072205916,-0.012951484,0.036055516,-0.06332146,0.0005449024,0.022153063,0.014596327,-0.01950951,0.05571927,0.016390061,-0.017436543,0.1456341,-0.029855773,-0.020935748,-0.06549127,0.045030553,0.0646108,-0.05108102,0.017676817,-0.10634279,0.08831524,-0.073972754,0.028273867,0.0065364107,0.02256259,-3.1250933e-05,0.07901891,0.09992414,-0.010674595,0.04363027,-0.02900205,-0.040568363,-0.073840946,-0.01811567,0.117222086,-0.015832298,0.024974415,-0.023363963,0.009853721,-0.023905607,-0.052997787,-0.009255074,0.009106203,0.07590439,0.028913226,-0.064300984,0.08626329,0.049984626,-0.07493436,0.09307902,0.03744452,0.04448315,-0.027522678,0.054168362,-0.05014362,-0.008193147,-0.11687934,0.03672311,-0.054444224,-0.01142359,0.008416776,0.053776648,-0.034563594,0.0019572936,0.037165646,0.06656124,0.0045748074,0.06935414,-0.04377339,0.018600408,0.036491927,0.06372072,-0.04867529,-0.013494881,-0.04444599,-0.06619726,-0.0206445,0.03790141,-0.047259428,0.061387222,-0.0123583125,0.059369776,-0.1187777,-0.021652097,-0.025985202,-0.03186667,0.08059518,0.0020852508,0.03713848,0.013706936,-0.011757599,-0.012095525,0.10530515,0.08285706,-2.7713703e-08,0.0020629421,-0.043003052,0.06410749,0.0114847105,-0.029380865,0.0061345003,0.018243209,0.010289631,-0.011784972,-0.11046729,-0.033183858,0.068196476,0.04874016,0.05165033,0.072820105,0.014030039,0.021563856,0.06218131,-0.019058933,-0.0021111376,-0.061080873,0.026323263,-0.06357904,-0.0038518799,0.052427474,-0.030642573,0.07277963,-0.048779894,-0.0107965255,-0.014427807,0.13983963,-0.005380619,0.043764334,0.014445987,0.017851137,0.042233746,0.016623028,-0.07041855,0.04079071,-0.018879393,0.031981725,-0.0040166923,-0.086742856,0.025953326,-0.039267067,-0.07858181,-0.008037107,-0.014713193,-0.09902266,0.00948992,0.100551404,-0.01217429,-0.0010227791,-0.053786688,-0.11519482,-0.049926285,-0.012491887,-0.06311802,-0.055979833,-0.09804934,0.03472782,0.02988035,0.16795851,0.091972776 +1.1.1.251,The enzyme from the bacterium Escherichia coli is involved in a galactitol degradation pathway. It contains two zinc atoms per subunit.,384,1.0,-0.027199367,-0.041796505,-0.038896743,0.044508625,0.066319495,-0.018024871,-0.024630517,0.04376295,0.03876306,-0.029236373,-0.013524776,0.009978297,0.025360318,0.046947982,-0.07299089,-0.018314881,-0.04539655,0.041924074,-0.03748689,0.016062712,0.1290289,0.047483325,0.007979305,-0.0023154197,0.026937,0.012342396,0.057219587,-0.04449843,-0.05620314,-0.04343029,-0.0104653565,-0.02585479,0.10363238,-0.022550778,0.029646527,0.05423649,0.0053591128,-0.049167868,0.060720492,-0.04905755,-0.007729062,0.091331914,0.020893492,-0.03487718,0.018587619,0.013804068,-0.016690986,0.0029411786,0.018071055,-0.035488475,-0.07647716,-0.063719384,-0.010209194,0.027160479,0.07074009,0.101787366,-0.03434275,-0.12940016,-0.0041217585,0.011577499,0.08740072,-0.025294703,-0.022631414,0.005662128,0.074191205,-0.07400869,0.02241505,-0.050687976,-0.033011135,-0.029523775,-0.09348943,-0.054750368,-0.0425644,0.022180026,-0.030320141,0.025378244,0.10345849,-0.059636265,0.06905857,-0.022293868,0.037018392,-0.022583848,0.015223468,0.056215294,0.047271907,0.027001124,0.04009798,-0.0048296032,-0.008091134,0.015858259,0.019239498,-0.04310397,0.037643265,-0.07470947,-0.050291047,0.03460643,-0.0033410024,-0.039651744,0.071010284,0.025944022,0.005124818,0.0288023,0.102554254,-0.08218884,-0.028608976,0.03294348,0.02189869,0.16586609,0.008118116,0.06450463,0.025941348,-0.052324302,0.017612176,-0.0065910504,-0.012609055,0.068809554,0.06814899,0.0018307844,-0.09236994,0.050219033,0.013913707,-0.040183716,0.014472045,0.028156376,-0.06002738,0.061552543,-0.058668986,4.516083e-34,0.032301035,-0.008362484,0.010113779,-0.0413924,0.033805188,0.027785208,-0.009581143,-0.027042361,0.018281993,-0.036463477,-0.06297938,-0.07316838,0.024589745,-0.054993495,-0.043013625,0.022494458,-0.05801531,0.019596294,0.02334049,0.015304602,-0.023521354,0.05563804,-0.032226328,-0.03891387,0.072156005,0.020850433,-0.0028852348,-0.037681956,-0.009755677,-0.011255077,0.054561555,-0.0018958703,-0.14131165,-0.0073709004,0.17870641,0.009775213,0.008861407,-0.025285076,0.034241747,-0.06486747,-0.0006814133,0.0032305093,-0.053689785,0.06409611,0.033651367,-0.0513378,-0.04123981,0.078185745,0.031018646,0.008997051,0.053135946,-0.012926377,0.0006998076,-0.046038114,-0.06068181,0.06267762,-0.01464809,0.06570822,0.03514764,0.05297838,0.002430434,0.086011395,-0.079782,0.09667678,0.059341207,0.04058684,-0.06996482,-0.04577032,-0.016287155,0.09723755,-0.07388223,-0.051212374,0.06355134,0.028245227,-0.043521106,-0.065376066,-0.069486685,-0.024068354,0.10496546,-0.036786437,-0.064823166,-0.047627617,-0.01781624,-0.002843832,-0.030618582,0.0040828334,-0.016710438,-0.0642497,0.014878122,0.03035072,0.058481902,-0.06402973,-0.040518705,0.038820677,-0.03214527,-2.1841216e-33,0.04422316,-0.04429485,0.09056335,-0.043168575,-0.028719472,-0.0035375284,-0.050159212,-0.042478643,0.030079952,-0.045249477,0.06860001,0.019934054,0.016851652,-0.046180863,0.0063872645,0.05134014,0.013056865,0.050091933,-0.032116376,-0.0046327687,0.032182936,0.044854973,0.040238403,-0.03625363,-0.016312929,0.020357152,0.035121594,0.06964463,0.06744981,0.037442755,-0.012814804,0.014711956,0.003072626,-0.12587085,-0.13279814,0.0009654791,-0.032704562,-0.002702822,0.018628554,-0.060904108,0.027086895,0.049270913,-0.004398923,0.061032556,0.062219884,0.07514313,-0.06014901,0.008134241,0.015371205,-0.06328907,0.00105842,-0.049856804,-0.033654932,0.037495192,-0.020583063,0.046855286,0.028874617,-0.020701008,0.00038116975,-0.047516458,-0.011163708,-0.022085326,0.08728144,-0.016370956,0.07238446,-0.05001223,0.025558982,0.07072268,-0.016259141,-0.055946924,0.06972822,0.04926749,0.030774303,0.011467252,-0.009644963,-0.012427338,-0.1296535,-0.067906864,-0.013316463,0.004532386,0.054020066,0.07788588,-0.042368103,0.0021672307,0.047622204,-0.08772356,0.06042664,0.1495671,-0.0142395655,0.017531106,-0.102854714,-0.016634762,-0.017520737,-0.001990897,-0.012579649,-2.5466557e-08,0.06344078,-0.025552029,-0.003301052,-0.12487559,0.015621629,0.034600727,-0.027135864,0.04289832,0.072389305,-0.014306752,-0.027659744,0.16014023,-0.052476775,0.012874539,-0.009824183,0.043347985,-0.07035968,-0.023756566,-0.021897618,-0.00011300989,-0.039977606,0.0073042717,-0.04302391,0.038816378,0.016845273,-0.042738773,0.02538925,0.074325904,-0.0812049,-0.07953727,-0.028829154,0.01830525,0.045654804,0.0074139233,-0.120908126,0.015060449,-0.026673753,-0.06457573,0.0017437628,0.04088482,-0.027144067,0.011810818,-0.0217438,-0.0073913187,-0.062056426,-0.03462966,-0.03842896,0.033810064,-0.020243011,0.036071014,-0.037358467,-0.068504095,-0.10084089,-0.061481208,-0.051599197,-0.03560303,0.008901638,-0.054009527,-0.0057401047,0.0014361697,0.030123236,-0.039446745,0.162278,-0.02851148 +1.1.1.252,"Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC 4.2.1.94 scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi.",384,0.99999994,-0.039461214,-0.0026990874,-0.07649096,-0.011453776,0.091253206,0.11359241,-0.030578142,0.052185487,-0.010575307,-0.013315115,0.01847223,-0.1088054,-0.06430461,-0.0071909577,-0.103493914,0.020847501,-0.05261764,0.12455281,-0.04566493,-0.027163355,0.035097163,-0.019936701,0.030966606,0.064004585,0.08264607,-0.04285224,0.017471496,-0.02692576,-0.067076795,-0.016350567,0.010246867,-0.0032295263,0.019631827,-0.03259129,0.0020387946,0.039516237,-0.060681213,-0.017486813,0.015878784,0.044451337,-0.010107788,-0.025442574,-0.0028370412,-0.08074248,-0.05059659,-0.015828198,-0.036133453,0.05251711,0.011983281,-0.059213016,-0.05072587,-0.028752523,-0.03639012,-0.024046568,0.04387603,0.013717089,0.023926495,0.020656837,0.004034851,0.10880539,0.07679747,-0.103699796,0.030465739,-0.049125746,0.02223522,-0.036383487,0.00080263533,-0.048365682,-0.013782553,0.003749191,-0.009521069,-0.019759629,0.0030432483,0.0018780077,-0.052750096,0.0970004,0.0351846,-0.049041796,-0.04504968,-0.017933687,0.034096517,0.035445858,-0.0020582292,0.041938454,0.020114888,-0.00796411,-0.049314108,0.0053231576,-0.003910579,0.13546191,0.09012542,0.085599616,0.050087523,0.013991659,-0.107628964,0.09536555,0.075730704,0.024022516,0.02413653,-0.016120968,-0.011107299,-0.019351909,-0.0892594,-0.043224692,-0.028320253,-0.057106473,0.06484199,-0.019250134,-0.037277713,-0.010327885,0.09485415,0.003777531,0.0057331077,0.01991208,-0.067046985,0.058887653,0.05678851,-0.017832141,-0.0048870733,0.017619474,-0.013263075,0.013902489,0.06636888,-0.017179506,-0.0103704,0.013988375,0.0032197854,6.400389e-33,0.067884065,0.07159208,-0.038231496,0.030692756,0.08235942,-0.005550618,-0.10904501,0.044473432,0.023459282,-0.13762373,-0.09580582,-6.0036446e-06,0.024333071,-0.05201098,-0.054207485,-0.014712136,-0.019849038,-0.037985146,0.043891396,0.009031154,0.022382,0.0047722743,-0.09258328,0.024569554,-0.06226026,-0.032198403,-0.021933395,0.0560017,0.019419061,-0.020232685,-0.028099788,-0.06027824,-0.046688568,0.02920303,0.08797158,-0.037610244,-0.058008887,-0.036123578,-0.005930549,0.009844816,-0.0062476075,0.0626855,-0.02090409,0.027790032,0.037556995,0.028636804,-0.04407751,0.11054015,0.030486483,0.045766406,0.030957421,0.03870337,0.11369583,-0.025742084,-0.04377311,-0.055910457,-0.008762273,-0.047930863,0.026534988,0.060782947,-0.0059961313,0.068312794,-0.004543843,-0.047844727,0.03731893,-0.049310513,-0.10280032,-0.06739823,-0.010436285,-0.16165775,-0.008477354,-0.024269491,0.10329786,0.044354998,0.02127625,-0.004796117,-0.0048992657,0.028007776,-0.041632425,-0.013978409,-0.037234463,0.06694616,0.04631615,-0.036407635,-0.018148664,0.0028934202,-0.06181495,-0.010565817,0.0875364,-0.03637691,-0.012989804,-0.15252696,-0.07068615,0.030601934,-0.0011354424,-4.893693e-33,0.03067794,-0.022920627,0.025083283,0.029098073,-0.0048499964,0.047188226,0.0033985183,-0.016074862,-0.011581195,-0.024052177,0.096007206,-0.019580377,0.092946544,-0.033797953,0.031475086,0.007906789,0.039712753,0.0783888,-0.060464196,-0.024627363,-0.046619974,0.06540658,-0.078265965,0.0428085,0.019236244,0.037860412,0.0176465,0.013765348,-0.058553334,0.044746265,0.030647045,-0.021489391,-0.04726897,0.040586416,0.012301582,0.0011588272,-0.005001959,-0.039515484,0.04000042,0.06463256,0.009135743,-0.038249627,0.0021097092,0.065524064,0.053987365,0.06424434,-0.08403846,0.0194081,-0.035630893,0.031444926,0.05685777,-0.018434322,-0.025601186,-0.0014718398,0.058369696,-0.07042196,0.08951354,-0.007778093,0.011984002,0.055639412,-0.010313601,-0.030181626,0.02572118,0.028506907,-0.053371094,0.062027723,-0.038296442,0.13354297,0.09203013,-0.1151229,0.08749287,0.038365,0.046484824,0.040890835,-0.07097382,-0.046305474,0.028944066,-0.014883179,-0.022889301,-0.0021815782,0.031150157,-0.02684222,0.053851824,-0.059444323,-0.026581608,-0.011512049,0.08492537,0.02701208,-0.10495659,0.02382858,-0.051076088,0.010886514,-0.042030115,0.12371723,0.10952865,-3.748962e-08,0.04175587,-0.042422317,0.05137176,-0.029491851,0.03813052,-0.062140625,0.033752307,0.07603228,0.06022838,-0.047796927,-0.06910173,0.036919378,0.028115733,0.06351193,0.050367847,0.013303767,0.040010005,-0.0190982,-0.027928127,0.031766832,-0.033424824,-0.035065986,-0.091287546,-0.016068507,-0.010701212,-0.057561684,-0.012375022,0.030331023,0.07182961,-0.07168502,0.055099383,-0.02734677,-0.009823678,0.02979374,-0.052391578,0.02010345,-0.04920023,-0.04144343,-0.009099389,0.042765472,-0.02113373,-0.055722486,-0.05926455,0.05073793,-0.03975943,-0.07377195,-0.051178038,0.081849106,-0.020343164,0.0024868625,0.04454787,0.001371188,0.008751111,0.015199445,-0.065519,-0.09800335,0.07870905,0.059043765,-0.07890396,0.008355688,-0.01662295,-0.0012146119,0.09640128,-0.020043323 +1.1.1.254,"Specific for the (S)-enantiomer of carnitine, i.e., the enantiomer of the substrate of EC 1.1.1.108 carnitine 3-dehydrogenase",384,0.99999994,-0.070678964,0.006552078,-0.067236334,-0.07706452,0.032435518,0.027292427,-0.046655264,0.056902833,-0.037775327,-0.054643486,-0.00056598266,-0.152931,-0.053107224,-0.025589004,0.01611324,-0.03641211,-0.03574302,0.0012594827,0.0651817,-0.018008247,-0.017653719,0.036553595,-0.0054617226,0.05404797,0.04901342,0.007603093,-0.041924708,0.047656193,-0.062043976,-0.07727575,-0.00045966735,-0.10074181,0.094494514,0.011326516,0.021575589,0.057956953,-0.10098959,-0.026204228,0.03553749,0.06706622,0.023878185,-0.016634695,-0.10864367,-0.023650732,-0.010545387,-0.04419028,-0.06468592,0.060116537,-0.01783147,0.0134526035,0.02902871,-0.04582277,-0.002853551,0.008050705,0.057613138,0.009161838,0.00039467303,0.04997289,-0.051283766,0.0645771,0.08243073,-0.014362393,0.0113455895,-0.025852924,0.05812973,-0.017736824,0.095708534,-0.08548729,0.00037046502,0.018557297,-0.019163305,-0.062189076,-0.05782932,0.013438159,-0.08421286,0.039232887,-0.044833086,0.04909297,-0.034254808,-0.05386696,0.0846375,-0.0069677774,-0.012279359,0.004940816,0.02451904,-0.032517575,-0.019136127,-0.05420186,0.03899514,0.100414194,0.027101073,0.0044416576,-0.010710203,0.021341393,0.028981267,0.012530533,0.048445616,0.05042673,0.023804342,-0.08294515,0.058643084,0.05914874,-0.045649685,0.017881872,-0.007917158,0.005478141,0.03571181,0.048913456,-0.0617923,-0.025172234,-0.01505153,-0.048814,0.07792369,-0.031471793,-0.05335818,0.10320237,-0.0011637749,-0.0152141545,0.09881666,-0.020554474,0.04985786,0.011080458,0.009033813,0.005749422,0.04415744,0.04644362,-0.06697049,-1.7715216e-33,0.035572875,-0.018770888,0.026621444,0.04162002,0.0018675916,0.014045722,-0.07185398,0.0987871,-0.037170492,-0.015129812,-0.06391833,0.014719445,0.076889865,0.04509499,-0.0074285287,0.019164464,-0.07282096,0.011498579,-0.02952316,-0.021072729,0.01855685,-0.04329573,-0.0959604,0.047437698,-0.094068736,0.04105767,-0.034976367,-0.033527575,0.039914347,-0.03548268,0.020613506,-0.017628474,-0.03143557,0.0107423635,0.05485708,-0.08075938,0.038798578,0.022241259,-0.019252073,0.0406412,0.067953035,0.053465087,0.04282717,-0.05010262,-0.0009074277,-0.028686516,-0.024427984,0.03618404,0.07381617,0.011329006,0.08632615,-0.0601531,0.04023092,-0.073075294,-0.019384691,0.1155043,-0.0785791,0.068064064,-0.027931793,0.036349695,0.0025400883,0.08409149,0.07163408,0.0059159645,0.049596414,0.029464712,-0.13783447,-0.073933,0.00449696,0.0020414498,-0.07350841,0.011559953,0.12961343,0.0024412945,0.040621307,0.05822528,-0.11568568,0.01397835,-0.07236099,-0.019225959,-0.014456576,0.018710654,0.004579367,-0.033777423,-0.041742023,-0.00031973072,-0.00736475,-0.05330831,0.07481176,0.09196467,-0.012592716,-0.030276857,-0.064204276,-0.014030425,-0.016047621,1.5992776e-34,0.07660623,-0.04778842,0.030395338,0.0005906296,-0.041500412,0.1651939,-0.0140170185,-0.03749574,0.04345231,0.061142255,0.0825961,0.09240834,0.107944794,-0.071651496,0.07286584,-0.0025342444,-0.10160724,0.00912411,-0.09043925,-0.012616696,0.038783863,-0.047608543,0.014961358,0.04128918,0.08466015,0.019982899,-0.032903098,0.0018697293,0.09373624,-0.02428112,0.027688252,-0.013399488,-0.005265522,0.048658576,-0.024889296,0.05116967,-0.013066234,-0.0031874573,-0.026776575,0.051458515,-0.08748036,0.00829383,0.010915592,0.03725919,0.050302546,0.020992763,0.036822442,-0.035080392,-0.038298033,0.007866023,0.01739102,-0.02942543,-0.052260842,0.0042296113,0.025340373,0.042328708,-0.01917487,-0.0013799921,-0.009156117,0.030410523,0.08463899,0.044434346,0.0070530963,-0.049510755,-0.013814816,-0.037663944,-0.04778109,0.054255582,0.056236442,-0.055230085,0.07337172,-0.02509855,0.030499674,0.03414788,-0.010447668,0.030988831,-0.03250424,-0.097942725,-0.031346403,-0.10212726,-0.0053346683,0.01752827,-0.0074640173,-0.028499411,-0.017054537,-0.036629517,-0.0013366502,0.06886355,-0.011939637,-0.005758259,-0.027776608,-0.053439073,-0.07460225,0.123462625,0.031364515,-2.858724e-08,0.12414128,-0.030661087,-0.022512246,-0.028850863,-0.03082416,0.026742421,0.035985637,0.00026156864,0.0016245118,-0.070826404,0.045568686,-0.003580593,0.024848234,0.030752113,0.060527727,-0.043441948,0.057777405,0.033453304,-0.03326495,0.051581398,-0.061435863,-0.018328315,-0.12267808,-0.08536071,0.014893245,-0.07236098,-0.013670026,0.051112898,0.039492857,-0.01254953,0.048209578,0.009395747,0.076315254,-0.012452634,0.024366066,0.021461628,-0.106755055,0.023362435,-0.065393716,0.0076062717,0.033575114,-0.110143915,-0.099448614,0.011262404,-0.031386726,0.032010905,-0.04679432,0.025706556,-0.02770754,0.04348213,-0.010278487,-0.004907276,0.0013891963,-0.012441854,-0.045392994,0.039336417,-0.058182888,-0.06351538,-0.011957377,-0.06835209,-0.04878526,0.05141267,0.12555274,0.021653933 +1.1.1.255,The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation. The enzyme is specific for NAD+ and does not use NADP+.,384,0.99999994,-0.054438826,-0.04676,-0.038100023,-0.0118606035,0.04223759,0.0078530945,-0.13980216,0.040956195,0.033162557,0.042016506,0.06203023,-0.015306132,-0.034108866,0.060593985,0.0029647523,0.06700476,-0.053320013,0.038379658,0.01251173,-0.040384084,0.04097915,0.025868002,0.04951769,-0.024093917,0.023760084,-0.031253766,-0.036275145,0.031376194,0.026534254,-0.10048212,0.06469535,0.031151196,-0.07440745,-0.016515924,-0.024413588,0.01511981,-0.05043026,-0.07501917,0.03126509,-0.013804038,0.012287222,0.004826096,-0.036835,-0.028629601,-0.07602867,-0.03295387,-0.068239756,0.0949962,0.022891082,0.04701165,0.00016329935,-0.028715193,2.5321253e-05,-0.008826788,-0.029756963,0.0071397657,-0.045002718,-0.038699236,0.009992356,-0.066822335,0.062032823,-0.03387975,0.026942026,0.023704888,-0.00781027,-0.011850084,0.04416071,-0.09217448,-0.046775248,-0.069640465,-0.10714794,-0.10303821,-0.02502581,0.08479661,-0.0097309,0.046289623,-0.046480566,-0.083339415,0.013250334,-0.057033937,-0.008208174,0.02117305,-0.029960614,0.08934727,0.05543005,0.02142496,-0.0008128699,-0.027988907,0.014389546,-0.009680162,0.04691623,-0.059090473,-0.04415417,0.031864237,-0.056913815,-0.00033453267,0.10612345,0.08538894,-0.054700714,-0.013611658,0.0332362,0.07004478,-0.027284022,-0.058882773,-0.007975495,0.010319837,0.012509732,0.0346623,-0.04680326,-0.02476867,0.05342974,0.023978313,0.05311679,-0.09435469,-0.025737638,0.13215579,0.00021902722,-0.039909784,-0.05679853,-0.030116465,-0.003908339,0.0007435719,-0.016099183,0.049502652,-0.020382492,-0.0029622654,-0.02838423,1.3450473e-33,0.043399505,0.0023281167,0.0020327866,-0.016882552,0.068386145,-0.005203173,-0.078071,0.1141511,-0.0094233295,-0.08654806,-0.12781033,-0.03277522,0.060764767,-0.021722639,-0.012467932,-0.0033431086,-0.0027238051,-0.04080648,0.033709697,-0.012447903,-0.006404962,0.015351699,-0.033325378,0.07076306,0.036252074,0.06383305,0.008650667,0.05954949,-0.035240375,-0.005113718,-0.0072044446,-0.07928772,-0.097355455,0.009025861,0.07607693,0.071094275,0.007027171,-0.04872224,-0.038741887,0.032050762,0.0030568058,0.10850077,-0.0007986535,-0.012953013,0.06433252,-0.05892205,0.002919167,0.102544084,0.03303366,0.030679073,0.09122206,-0.010772588,0.0629532,-0.0061068265,-0.0067877164,0.06506973,-0.011660139,-0.05687608,-0.004097172,0.04030533,-0.01624109,-0.01769979,-0.06456664,-0.006731958,-0.07533945,0.059725814,-0.0644378,0.0058027827,0.03282494,0.052054837,-0.061266925,0.06912646,0.060220744,0.0881861,0.021043655,0.034456663,-0.013799629,-0.016218206,0.053019244,-0.027622893,0.01914763,0.038862422,-0.037916686,-0.024497174,-0.013821008,-0.00741144,-0.06983065,0.004663744,-0.013859052,0.029024297,0.10387563,0.012627045,-0.049669813,-0.030009177,-0.027936561,-2.9049461e-33,0.034390673,-0.08126459,0.011187372,-0.028238388,0.011090753,0.040437825,0.012761871,-0.033733957,0.07017917,-0.06919079,0.076966025,0.02013551,0.10136201,-0.07174927,0.074204855,0.050968144,-0.070386946,0.12220495,-0.032267414,-9.611038e-05,-0.02676599,0.1296554,-0.012585189,-0.07696817,0.031988688,0.021935722,-0.1382147,0.060966853,0.07681759,0.093193844,0.020486291,-0.002781496,-0.06740474,-0.05125653,0.017921204,0.054396458,-0.084361404,0.06873802,-0.008213043,0.04894022,-0.012256619,0.010304179,-0.07336001,0.08532528,0.1297597,0.010763021,-0.09973461,-0.07576275,-0.002974532,-0.01476577,0.038623836,0.023437439,-0.01701504,0.024216913,0.049668565,0.08109196,-0.0379336,0.038294397,0.010017889,0.04210138,-0.013476536,-0.023004368,0.059487328,-0.016274054,-0.016688392,0.01670757,-0.071137935,0.036075428,0.046385903,-0.0086066825,0.0959485,0.033925354,-0.05274782,-0.020270402,0.008035248,0.0060092923,-0.086123586,0.0018795311,-0.11436689,-0.010725389,-0.07104766,0.0078570545,0.07707197,-0.078113295,-0.009791937,0.012830543,0.0004652298,0.027715987,-0.040666316,0.023494307,-0.007742779,-0.0009837883,-0.009330103,-0.010076141,0.037368663,-3.2080077e-08,-0.00910372,0.051325187,0.03582109,-0.036362898,0.021319717,0.06731448,0.039209615,-0.028516991,-0.012265139,-0.01878627,0.02385471,0.137917,-0.027529784,0.010340974,0.06729069,0.025143642,-0.04074927,-0.006906322,-0.03845226,-0.034521326,-0.020429973,0.040054455,-0.01678183,0.023328334,-0.0030621511,-0.01681716,0.055378817,-0.0260487,0.018716022,0.0025098252,-0.009670219,0.02034915,0.015991608,-0.08905498,-0.04452413,0.05650565,0.010817668,-0.00860135,-0.00033239613,0.025493808,-0.04982248,-0.07946156,-0.09614919,0.026211102,0.04119107,0.012367269,0.04752758,-0.02868426,-0.08456373,-0.0072496408,0.062351473,-0.02031435,-0.038667936,-0.039587785,-0.09537044,0.007242959,-0.040361024,-0.03231879,-0.068020225,-0.12483464,0.032880373,0.012446092,0.18600048,-0.018399423 +1.1.1.256,Involved in the pathway for fluorene metabolism in Arthrobacter sp.,384,1.0,0.009327344,-0.01657715,-0.084319465,0.041289102,-0.018110622,-0.010811118,0.0008555308,0.0848014,0.0062746108,0.0041287644,-0.049546394,-0.09002846,-0.022691738,0.028185226,-0.011195948,0.0010277298,-0.06815443,-0.022698177,-0.020427901,0.0019911348,0.019940354,-0.020170182,-0.052105945,-0.023565039,-0.022845237,-0.065233074,0.01941759,-0.099573165,-0.13549326,-0.05853149,0.0528478,-0.07260426,0.044091143,0.008382088,0.009506434,0.012810029,-0.019464955,-0.01678866,0.064804874,0.031358287,-0.0359062,0.06592463,-0.057736102,-0.04356275,0.018461484,0.04058646,-0.03929751,0.041369677,0.048785813,0.10096882,-0.084448904,-0.017565249,-0.08008928,0.079081856,0.04799816,0.023493905,0.015888354,-0.047024384,-0.08217414,0.05074273,-0.048974983,-0.029288573,0.04318928,-0.008322087,0.021088047,-0.015477159,-0.079048015,0.028686747,-0.051567905,-0.019133737,-0.05681501,-0.022758607,-0.003352798,0.02930763,0.063719206,0.049803272,-0.10415318,0.033464916,0.053131063,-0.0453016,-0.0073375166,-0.026229471,0.09075762,0.09912149,0.04457288,-0.0004270647,-0.008838361,-0.02384922,0.03288971,0.12869065,0.0350676,0.05037595,-0.040619735,-0.039245315,-0.023129027,-0.043347936,0.09366008,0.005796353,-0.013739694,0.004972083,-0.038279857,-0.07817638,0.07211241,-0.0053727776,-0.060633425,-0.04674319,-0.008162795,0.09242542,0.032083984,-0.015217854,0.001405908,0.10134702,0.046819076,-0.026846211,0.006717374,0.02892179,-0.08403469,-0.106521845,-0.012283961,-0.0040695104,-0.026206601,-0.0415439,0.024301993,0.03509294,-0.010343345,-0.011776669,-0.061208945,-1.3976998e-33,0.029455395,-0.0155138485,0.08225976,0.01886635,-0.013745369,-0.040173113,0.020745026,-0.04112512,0.04419461,-0.046092812,-0.022710986,-0.12679628,0.039897162,0.024941223,-0.07212742,0.07815751,-0.032244798,0.0057658744,0.033653412,-0.018682973,0.1029521,-0.021281507,-0.032857228,-0.027764944,-0.01916402,0.09333403,-0.10007372,-0.0017746997,-0.10379925,-0.0074044312,0.026515214,0.000669924,-0.034864817,0.03436952,0.030691188,-0.023316469,-0.008265123,-0.059591107,-0.16349432,-0.048965123,0.065811254,-0.0013412086,0.022437423,-0.011839958,0.026097836,0.017125595,-0.08234671,0.10827138,0.019285671,0.10437122,0.041637145,0.011233127,0.10588528,0.036183443,-0.047512937,0.00075109926,-0.06266639,-0.15096056,0.09084092,0.029750247,0.06813708,0.08531376,-0.0146885235,0.0455913,-0.0032594285,0.039426815,-0.061569337,-0.0036873436,0.010371319,0.13120946,0.023291254,-0.10109703,0.076110244,0.027271213,0.020769687,0.02870414,-0.082040645,-0.042596508,-0.07754852,-0.011955451,0.04039912,-0.045083474,0.01754507,-0.021424735,-0.07325927,-0.02941749,-0.011457096,-0.06459529,0.035157185,0.08589926,0.113662325,-0.04880827,-0.048433177,0.053511772,-0.012535617,1.0592789e-34,0.105328135,-0.048710328,-0.0471775,-0.042504277,0.018377773,0.019117832,-0.04898047,0.017119182,0.08622617,0.01309989,0.06305432,0.027723791,-0.0030833797,-0.06553648,0.016780395,0.021301432,0.11140931,0.041993156,0.044479672,0.024254546,-0.0800766,-0.004618254,-0.014338914,-0.060563914,-0.0068722996,0.070563234,-0.038968626,0.09404313,0.037064906,-0.032930646,0.03893047,0.09398193,0.002197146,-0.0722829,0.016712591,-0.030628443,-0.06348667,-0.058030874,0.07521371,-0.037557617,0.0024193872,-5.8880833e-05,0.043889347,0.07045924,0.0416289,0.08278509,-0.055603493,-0.062511526,0.006500865,-0.05112763,0.022384651,-0.0050677923,-0.023127384,-0.049518615,-0.034093376,0.08073224,-0.0131563535,-0.054865345,0.018909134,0.02439972,-0.010510675,-0.037490595,0.021528943,-0.04375481,-0.049977656,0.005822575,0.048904985,0.078762524,0.01961232,0.07052032,0.03916798,0.016259464,0.064724505,0.121914715,-0.030800765,-0.06459391,-0.040167153,0.008468738,0.036383215,0.06726372,-0.05234707,0.024728267,-0.0064956043,-0.111646056,-0.036364198,-0.057338405,-0.089300945,0.018898949,-0.02071995,-0.0049560023,-0.014243314,-0.058158785,0.031303037,-0.014280672,0.054268025,-2.0826219e-08,0.022705965,-0.059140213,0.026337141,0.031127559,0.017660627,0.031620137,0.032209754,0.07591021,-0.014099654,-0.012440912,0.059392605,0.03919065,0.029946903,-0.046635754,0.000614573,-0.0062413476,0.078552164,0.045472596,-0.025331467,-0.028733086,-0.07204102,-0.04045367,-0.009479808,-0.039635856,0.04921107,-0.077595495,0.009407995,-0.021802967,0.025435247,0.038400326,-0.03300609,0.002101058,0.06466975,-0.0042550266,-0.052763894,-0.0005683781,-0.040404513,-0.025872651,-0.021481985,-0.013251502,-0.012018058,0.025903573,-0.05850129,0.009043896,0.034872714,0.0052102916,-0.014974423,-0.024827885,-0.028629221,-0.07239863,0.041859925,0.025123406,0.008372817,0.008493874,-0.043550458,0.086571746,-0.0023724695,-0.023365667,-0.031633746,-0.013507458,0.021777203,-0.013557919,0.08157586,0.024805974 +1.1.1.257,Involved in the toluene-4-sulfonate degradation pathway in Comamonas testosteroni.,384,0.99999994,-0.009236225,-0.027159467,-0.05110638,0.0023645286,0.016924761,0.06324813,-0.06550499,-0.004560112,0.021626115,-0.00919049,-0.004116614,-0.05384938,-0.036655914,0.056402206,-0.13176405,0.04945297,-0.038356256,0.01990789,-0.019477284,-0.01882138,0.06834206,0.02267738,-0.031249829,0.014385568,0.0159204,0.011195566,-0.022247849,-0.07325127,-0.08180872,-0.018714882,-0.019020671,0.009615922,0.010678868,-0.047668055,0.051919136,0.12717873,0.078589074,-0.06813663,0.12827449,0.011094383,0.07644193,0.055619556,-0.045465227,-0.034132138,0.02900904,0.041511554,0.0076965583,-0.022025589,0.05432857,-0.11690458,-0.031501766,-0.033670943,0.07298124,-0.027152276,0.012024464,0.022839876,0.08482887,-0.00071160874,-0.039223418,-0.023757337,0.03012341,-0.05999323,0.01811493,-0.021657338,-0.0035700076,-0.018981557,0.075060554,-0.0021007608,0.009266868,0.00057798263,-0.12852304,0.013227933,0.0135941375,0.05296364,1.6891334e-05,0.10436435,0.07107103,-0.057436675,0.06207985,-0.087832026,0.051949456,-0.035319872,0.014985697,0.0044174884,0.057663787,-0.055057097,0.046662606,-0.057218414,0.075205736,0.058581244,-0.003742765,0.009068133,0.02712832,-0.05534813,-0.062319785,0.006756273,0.03562035,-0.022327574,0.017543772,-0.028957319,0.020307615,-0.05008737,-0.074205145,-0.09152176,-0.059567258,0.014322713,0.036181662,0.037321284,0.08509779,0.019224059,-0.008491317,0.022026615,0.106737316,0.004158051,-0.021569474,0.04581661,-0.0017021212,0.008016901,-0.09637998,0.041037094,-0.041805416,-0.04726441,0.009547959,-0.0038555397,-0.019464314,-0.0294004,-0.031297673,-1.0137531e-33,0.13948001,0.042602643,-0.000214448,0.009864868,0.008694132,-0.043044608,-0.046230525,0.051470973,-0.034750003,-0.07769853,-0.0059669786,-0.1255591,-0.030583348,-0.060878575,-0.05794581,0.041692648,-0.019165104,0.016354855,0.03439548,-0.029396046,-0.12281119,0.010001112,-0.029130816,-0.07633364,0.089528225,-0.012855701,0.03898652,-0.044507664,-0.065882295,-0.013876609,-0.006260758,-0.057116248,-0.10532599,0.03155332,0.08145569,0.018859388,0.024478288,0.0213724,-0.036503956,0.012085427,-0.030909875,0.02998778,0.0019943402,-0.024450954,0.0034451298,0.008150893,-0.04050668,0.07092296,0.09198363,0.043088533,-0.051338058,-0.07985654,0.103606656,-0.0476844,-0.07231113,-0.013817033,-0.0155011555,-0.028301623,0.074984685,0.04577782,0.021049054,0.07122372,-0.11011987,0.016700812,0.022083843,-0.0127797695,-0.06927518,0.009800386,0.030414231,0.03969226,-0.060061827,-0.042550977,-0.039713036,0.009733002,-0.017334273,-0.031513482,-0.06271958,0.041384168,0.014991291,-0.00018514466,0.07058155,-0.12072015,-0.0135141965,-0.00799839,-0.08574383,0.09306382,0.03996061,0.035440467,0.050733496,0.015530799,0.10452246,-0.053126775,0.025631322,-0.017919816,0.08549572,3.984785e-34,0.056663636,0.018208869,-0.05871536,-0.02499743,-0.09068591,0.021658808,-0.00467071,0.031009655,-0.06212315,-0.0058326046,0.09862766,-0.033467855,-0.0038327184,-0.045755208,-0.018041136,0.021032074,0.042391118,-0.041916866,-0.026701866,-0.06378855,0.020048637,0.075586244,-0.06732702,0.029804766,-0.042772915,0.045010455,-0.016804302,0.06370104,0.064799584,0.054068074,0.025721967,0.047538895,-0.03286698,-0.0060526994,0.025754105,-0.024782501,-0.043960925,0.02842077,-0.0021625927,0.060815442,0.0010763475,0.016050123,0.029664367,0.036834344,-0.017706443,0.03269036,-0.048313893,-0.045185227,0.072091185,-0.008564727,0.034832716,-0.04038925,-0.027662046,-0.028285218,-0.011034114,-0.038676426,-0.032149207,-0.04445773,-0.07986814,-0.004336976,-0.077045806,0.0101687675,0.049747564,-0.008697215,0.0034336993,0.06410845,-0.042581346,0.051216513,0.008491206,-0.032693923,0.03370299,0.0064562005,0.11616267,0.014146053,-0.07039773,-0.006615323,-0.070287205,0.016564613,-0.012138541,0.03366581,0.022369554,0.003811002,-0.012117068,-0.08172252,-0.008377253,-0.048886444,0.01020873,0.092641585,-0.029261163,-0.011440774,0.0020019317,-0.046727266,-0.024346013,0.00033356,-0.01426448,-2.1739345e-08,0.005535264,-0.06336309,0.04734336,0.058197286,-0.075765185,0.0116953775,0.10639418,0.08131252,0.094803475,-0.025041163,-0.018839313,0.059634656,0.022325804,0.024206042,0.06318845,0.009757401,-0.10037506,0.010232851,0.0045656944,-0.012274795,-0.09180422,-0.10260384,-0.1024735,0.054157503,0.096175835,0.0073210313,0.09869426,0.034302846,0.063084505,-0.072159626,0.035516374,-0.018086413,-8.502374e-05,0.0027588035,-0.0018833494,0.06301619,-0.08140181,-0.011945462,0.032237515,0.113543324,-0.04029357,0.08277605,-0.098666266,0.043963958,0.03585033,0.011432877,0.024662226,0.05963536,-0.023798777,-0.052511,0.01655985,-0.010045143,0.014834264,0.011053475,-0.0884817,-0.007970642,0.075862736,0.031339124,-0.028349241,0.01737928,0.061383076,-0.07650992,0.08961817,-0.024384495 +1.1.1.258,Involved in the cyclohexanol degradation pathway in Acinetobacter NCIB 9871.,384,1.0,-0.09001944,-0.039488792,-0.06955183,0.035498254,0.006181468,0.038097855,-0.037667044,0.03210562,0.020601913,-4.4353455e-05,-0.04107317,-0.03874207,0.06723504,0.024606256,-0.08752127,0.07214128,-0.051940314,-0.009701484,0.02082049,-0.051322505,-0.026256422,0.096442275,-0.047795963,-0.052557603,-0.006613538,-0.015534947,-0.014075426,-0.0386711,-0.077959105,-0.013189012,0.0610611,0.018777095,0.023691373,0.017630195,0.17760396,0.016167266,-0.007992927,-0.05720991,0.106806085,-0.022695657,0.022608139,0.07518502,0.0025983048,0.07071927,-0.027027713,0.09049678,0.037838962,0.022247782,0.06308362,-0.037468724,-0.00060084165,0.013998992,-0.03778315,0.03912905,0.044681385,0.052382156,-0.0754486,-0.090330355,0.0041052722,0.036322635,0.03610874,-0.014493769,0.017012822,0.027451731,0.02997808,-0.026514642,0.04110017,-0.0528864,0.012615638,0.021718178,-0.10202742,-0.03039704,-0.0043838047,0.0035697457,0.013082183,0.037073735,0.029338175,-0.085924804,-0.044018537,-0.06070721,-0.0398609,-0.035915967,0.05956804,-0.0006906092,0.020239096,-0.08816773,0.06658353,-0.040301092,-0.0025935995,0.05845689,0.03825815,0.039089404,0.078748204,-0.06756053,-0.04928223,-6.611247e-05,0.10464523,0.023066895,0.01362729,-0.009789493,-0.053308625,0.08453371,0.033862744,-0.04063392,-0.016028048,-0.067523666,0.0187971,0.09904638,0.013903227,0.04286255,-0.06498499,-0.028872954,-0.043486934,-0.043654796,0.0382849,0.02281852,0.0352948,0.054130968,-0.06478421,0.047502384,-0.06937582,-0.0615611,-0.01213235,0.056040436,-0.032677755,0.047545943,-0.026516855,1.8041373e-33,-0.00878482,-0.038080703,-0.014019301,-0.05304959,0.03569836,-0.051150337,-0.025357163,0.017394362,0.027752915,-0.05509345,-0.02855235,-0.07273011,0.05194416,-0.05083784,-0.085183576,0.041527327,-0.11367599,-0.0295615,-0.01098345,0.0299509,0.0034993705,0.052695308,0.06239354,0.04453258,0.015195515,0.015067964,0.01981993,0.05629799,-0.016253173,-0.024456186,-0.020339044,0.008537903,-0.096668676,-0.075474985,0.10637201,-0.019831806,0.0026773936,0.012557341,-0.011690399,0.1382298,-0.09054318,-0.0008521615,-0.023193525,-0.035384018,0.081578314,-0.019124113,-0.067357376,0.11548927,-0.019634204,0.012018731,0.024448076,-0.036189117,0.026990633,-0.014401682,-0.023625452,-0.053283684,-0.030302808,0.0047827056,0.021750847,-0.094349794,0.09603498,0.047192413,-0.051203113,0.006634042,-0.012253901,0.013628442,-0.056454994,0.028900037,0.036767423,0.03873197,-0.039207716,0.0010247689,0.078718156,0.039804112,0.08152366,-0.020679966,-0.067433685,0.00017907648,0.06371288,0.021300538,-0.001682901,-0.040538862,0.041615266,-0.014498558,0.017012931,-0.06953796,-0.012933913,-0.018399192,0.016123928,-0.025512343,0.12333492,0.009032658,-0.05455091,0.031854615,0.0018030717,-2.7240879e-33,0.12823616,-0.019426128,-0.02095762,-0.03436733,-0.047618307,-0.011185096,-0.067403115,0.03771795,-0.023811227,-0.062156405,0.079932764,0.03927652,0.010560709,-0.03153042,-0.0021299133,-0.07576624,0.01232244,0.062343605,-0.09863907,0.028208703,-0.011218639,-0.005982528,0.010679058,-0.06611188,0.028142963,0.0026413908,-0.054214843,0.07322924,0.05154347,0.029714968,-0.046748333,0.08384164,-0.008511833,-0.070811555,-0.09154856,-0.0016782872,-0.06049831,-0.013066334,-0.0034774945,-0.007618106,0.07028288,0.014098497,-0.078243494,0.0039761583,0.050359506,0.035596583,-0.019169524,-0.028403394,0.03020193,-0.05809744,0.04959305,-0.045926064,-0.0047149016,-0.014431812,0.0061035147,0.15364397,0.031054335,0.017328575,0.09185649,-0.008639573,0.0048212907,-0.014924719,0.08348935,0.03802952,0.071522,0.01146357,0.019026984,0.16405837,0.018126486,-0.022771455,0.012710934,0.0781414,0.0139751425,-0.041732665,-0.029899942,-0.0007260674,-0.06228903,-0.03262701,-0.088102564,0.019500054,-0.053233966,-0.0074581252,-0.033396665,0.0065498543,-0.030173765,0.03609891,0.0012483374,0.0038252783,-0.042378742,-0.020926436,-0.034218248,-0.037470642,-0.03385584,0.06006597,-0.021980438,-2.2481595e-08,0.021747895,0.023358295,0.023746183,-0.014566347,0.08671999,0.08996509,-0.0073972438,0.047016602,0.06293542,-0.0492136,0.02386143,0.043664303,-0.0035699909,0.008686881,0.019759405,0.057831448,-0.09836817,-0.087012276,0.046616454,0.05792998,-0.14162588,-0.0664506,-0.015517821,0.071392275,-0.0029136508,-0.057564963,0.0600506,0.07124838,-0.014575914,-0.08357076,-0.025291009,-0.030754644,0.037489463,0.007876468,-0.031257078,-0.027559215,0.024028739,-0.07745216,9.419275e-05,0.04509268,-0.053901207,0.107141405,-0.09184443,0.026127921,0.07563106,-0.012172228,0.03719731,0.00037718518,-0.0800776,-0.056704935,0.012990536,-0.008371315,-0.087887615,0.01862292,0.00030652282,0.018970266,-0.016199917,-0.030968267,-0.06013417,0.009592336,-0.08040348,-0.059078395,0.0856634,-0.04987931 +1.1.1.259,Involved in the anaerobic pathway of benzoate degradation in bacteria.,384,1.0,-0.046073638,0.026255924,0.00027083536,0.012863867,0.06969275,0.07719645,-0.03276323,0.034671977,0.024612684,-0.025252441,-0.051860873,-0.083675526,0.011719785,0.10702859,-0.090432785,0.01737483,-0.10230335,0.024897367,-0.07097491,-0.005515985,0.0114771025,0.052591868,-0.0022138536,0.0377972,0.002286739,-0.08538392,0.008828952,-0.044707917,-0.09444002,-0.032828327,0.04292604,0.005928552,0.07704751,-0.05441394,0.10315132,0.056964885,0.007716919,-0.05939963,0.12857716,0.05363441,-0.020812618,0.0039884085,-0.07037172,-0.016354498,0.05669365,0.08601682,0.05787074,-0.026564639,0.037700754,-0.061774973,-0.06558621,0.0193066,-0.02957129,-0.024432054,-0.030795695,-0.004098556,0.04327557,-0.011501342,-0.06199589,0.035952777,0.052747067,-0.021723643,0.01942904,0.004048686,-0.09561926,-0.03995068,0.071842834,-0.025804212,0.035480767,0.021725938,-0.15549141,-0.071035735,-0.026154403,-0.021604853,-0.009841375,0.01068124,0.006560224,-0.08023717,-0.061092336,-0.10448265,0.021506108,-0.06193671,0.017923297,-0.014136618,0.012497109,-0.06228202,-0.005610776,-0.036671244,0.10712592,0.075051956,-0.037554536,0.04197473,0.02217913,-0.0716609,-0.05895567,-0.0133947395,0.0478084,0.044437,0.039463326,-0.00791582,0.023167055,0.08206927,0.0077397744,-0.07120585,0.0478633,-2.6980442e-05,0.10801134,0.111632325,0.015814938,-0.015200196,0.025938453,0.017901788,0.05067351,-0.026179802,0.00094158406,0.06805747,0.04462314,-0.022198465,-0.1176849,0.094952345,-0.005982054,-0.070563465,0.024584102,-0.028010843,-0.060679752,0.0011833657,-0.045271568,-1.3304841e-33,0.030474732,-0.019099798,-0.0041203685,-0.01763529,0.005436374,-0.048706453,-0.10767992,-0.08554347,0.0625914,-0.0788106,-0.0066432264,-0.04849846,-0.019815573,-0.018359197,-0.03735976,0.06373566,-0.042961538,0.043780334,-0.056105822,-0.015447164,0.008804297,0.013380917,-0.03364943,-0.088478975,0.089952596,0.013699276,0.005486823,0.025423376,-0.07652187,-0.03675082,0.009825576,-0.042469457,-0.14616925,-0.009912781,0.049690258,0.025345588,-0.050704226,0.027741157,-0.0023500952,0.04356412,0.02962237,0.09466081,0.03420348,-0.0038451718,0.0069751395,0.01216803,-0.03931532,0.13184944,0.06786478,0.0021172117,0.027433723,-0.0590121,0.0074283364,-0.010417386,0.0020722596,0.035995696,0.07653101,0.035063982,0.031201394,-0.02226528,0.05019763,0.07132789,-0.09367161,0.03273744,0.039974608,-0.020050047,-0.04804452,0.09781626,0.002176445,0.021722155,-0.07904109,-0.023312122,0.056504995,0.094767846,-0.021749549,-0.07823276,-0.11455065,-0.06681212,0.04699432,-0.015124304,0.019451022,-0.045808215,0.013034295,-0.04406606,-0.01974106,0.011605,0.011295184,0.01823237,0.034393325,-0.0044114557,0.03449255,-0.06355504,-0.01778171,-0.036744203,-0.018258935,-5.8589104e-34,0.07383396,0.08070499,0.009700212,-0.011004211,0.00494185,0.017383635,-0.032988377,0.045467522,-0.05365956,-0.028977508,-0.017570797,0.015560352,-0.00049237406,0.018507918,0.033854842,-0.03969911,0.0947496,0.0127444975,-0.0725812,-0.051903702,-0.05829404,-0.01823193,-0.009679033,0.0005624352,0.008974512,0.047021516,0.0029820327,0.056295715,0.010013289,0.029492646,0.015254526,0.056702185,-0.03763096,-0.06850025,0.03395953,0.031446286,-0.031821806,-0.012855505,-0.029228985,-0.0044096275,0.005590521,-0.09080173,0.0021065683,0.016306113,0.022074562,0.0529076,-0.07054525,-0.054751527,0.024733689,-0.023531742,0.02428939,-0.023142219,-0.029106537,-0.017877137,0.026447745,0.036527086,0.027205506,-0.013127423,-0.013035004,-0.023249036,-0.025227213,0.025866535,0.06569952,-0.016737508,-0.025152361,0.027809195,0.017287062,0.12813091,0.0053036404,-0.011608023,0.04079349,0.07901788,0.087074794,0.04343324,-0.10397066,0.0060769925,-0.046314232,0.017940892,0.02988372,-0.018518131,0.040229037,-0.00980347,-0.03302126,-0.06335338,-0.054635454,-0.079284415,-0.047722366,0.01293644,0.0077275606,-0.054034263,0.060678422,-0.09232288,-0.010695005,0.056270413,-0.0037532123,-1.7411894e-08,0.027891088,-0.03044951,0.05625386,0.012505972,-0.024138145,-0.028621586,0.009771002,0.029917851,0.08934421,-0.045485478,-0.031898633,0.018444652,0.033225805,0.022686465,-0.022581404,0.021982992,-0.0705675,-0.004147161,-0.009853799,0.09952327,-0.08250154,-0.026533538,-0.08199076,0.05809979,0.082200654,-0.049148742,0.0584487,0.063178115,-0.0012974619,-0.067337915,0.05298776,0.03743579,0.024783943,0.093907714,-0.04900364,-0.054614045,-0.010778079,-0.0481847,-0.04127837,0.043066747,0.0017166262,0.016752679,-0.13000116,-0.0129444385,0.12554538,0.051949706,-0.029734388,0.10171899,-0.030778851,-0.067046635,0.0380882,-0.016095553,0.009219299,0.06463854,-0.05635269,0.04032702,0.05401502,0.04517183,0.03252632,-0.025146985,-0.009808321,-0.01926571,0.12959914,-0.052546833 +1.1.1.260,"Studies on the effects of growth-stage and nutrient supply on the stereochemistry of sulcatone reduction in Clostridia pasteurianum, C. tyrobutyricum and Lactobacillus brevis suggest that there may be at least two sulcatone reductases with different stereospecificities.",384,0.99999994,0.053719956,-0.039171856,-0.08294893,-0.065092094,-0.06672645,-0.004332915,-0.047099512,0.0077218283,0.016163282,-0.05417082,-0.021769106,0.0031272974,0.03514534,0.014958875,-0.08107158,0.015720077,-0.007812382,0.085821696,0.034060482,-0.0075566326,0.055464204,-0.04887195,-0.053369246,0.027908018,0.020996146,0.049669694,-0.012802286,-0.020422867,-0.16672242,-0.052622255,-0.04747289,-0.021687662,0.04090787,-0.055555962,0.03759813,0.045416985,-0.006779038,0.020818718,0.088463984,0.04603994,-0.031637534,-0.001072097,-0.010600896,-0.015193222,-0.08628052,0.010250977,-0.042756774,0.027785154,-0.026405958,-0.09777981,-0.052979182,0.00092275,-0.039638128,0.050007105,0.05313844,0.014195425,0.0059724925,0.01401536,0.045100007,-0.029880784,-0.031877935,0.0018214404,0.059452098,-0.07567677,0.032294676,-0.035884857,0.032050885,-0.047865566,-0.054743398,0.021863168,-0.0356415,0.021160722,0.0054990505,-0.050319612,0.006407558,0.07336133,0.030359777,-0.047603354,0.021233639,-0.030198857,0.00080262223,0.04924589,-0.06896948,0.056732688,0.007158048,-0.040094823,0.013575772,-0.03507851,0.024241203,0.021972239,0.06282836,0.044690277,0.014513982,-0.07795588,-0.018174049,0.004571347,-0.07261122,0.051026862,0.018197088,-0.06104582,0.023414971,-0.04897099,-0.054665715,-0.063777685,-0.062083438,-0.036910836,0.048587434,0.10466783,-0.03588355,-0.0137367165,0.013154523,0.03538394,-0.008131842,0.06693568,0.0145502,0.13597006,0.13190635,-0.074747965,-0.1362411,0.0065475893,0.0034435617,0.02596898,0.009308007,-0.022063708,0.04101402,0.03255431,-0.020178251,4.153571e-33,0.058813225,0.045329172,0.060233966,-0.02725049,0.046744574,0.006043796,-0.069860525,0.04043152,0.035026357,-0.02089026,-0.05233715,-0.017613001,-0.008468575,-0.029697578,-0.074306145,0.015798813,0.0026604864,0.09423734,0.0064341626,-0.027655402,-0.026074652,0.047447562,0.02353016,0.0090060225,0.03538526,-0.0076045925,-0.043329272,-0.062364392,-0.040926807,-0.014706996,0.09021375,-0.10058676,-0.023650637,-0.020566346,0.06231271,-0.06321186,-0.030796047,0.014649286,-0.06313579,0.003965319,-0.0055630472,0.054888256,-0.0163986,0.005574093,0.006141148,-0.040670667,-0.04562078,0.0956997,0.042054106,0.04496115,0.030337246,-0.018435307,0.031123891,-0.0903587,-0.009086066,0.046648238,-0.003423281,0.010475118,0.10832318,-0.008548712,0.03696366,0.105964035,-0.03373954,-0.063917056,0.03770278,0.00337935,0.0015334231,0.0062072943,0.020045418,0.011029191,-0.037744015,-0.105156526,-0.0902161,0.084527954,-0.0027767273,0.013725332,-0.034602966,-0.04585708,0.014936306,-0.0038613582,-0.0666912,-0.024043418,-0.004477048,-0.07263434,-0.043303832,0.013277226,-0.08528962,-0.011928097,0.049103934,0.017744465,0.052981887,-0.056442045,-0.1608458,-0.06069254,0.015172719,-5.8852285e-33,0.053606294,-0.06897408,0.028151935,-0.08146241,-0.0488274,0.033890925,0.0020395354,0.02102441,0.022046369,0.0077650766,0.013077499,0.07108615,0.0056102015,-0.006496481,0.0028346155,-0.013162828,0.070811875,0.023884112,-0.016799105,0.010455516,-0.036691613,0.114182666,0.06501432,0.044559482,0.005218318,0.037487797,-0.0086276475,0.06660327,0.08540488,0.007815195,0.048313543,0.05583382,-0.010333567,-0.092527226,-0.0354552,0.052615717,-0.07224764,-0.004533066,-0.0048887003,0.028732838,-0.036208842,-0.046896227,0.007695084,0.032954954,-0.013663169,-0.025239455,-0.0031275058,0.025852527,0.03732011,0.0161842,0.041128803,0.0034572592,0.049410496,-0.047960766,0.04053866,-0.036414996,-0.045266785,-0.01600497,0.009785601,-0.06712857,-0.023070604,-0.037130024,-0.039689492,-0.081969984,-0.03611858,0.044452354,0.009053452,-0.027266337,0.07224915,-0.050981645,0.024198074,0.015454447,0.024576334,0.0029268395,-0.11616408,0.0016245685,-0.07605838,0.07229204,0.023011627,0.05895823,-0.057232857,0.055631336,0.033243287,-0.09710319,0.02947551,-0.01150893,-0.039623186,0.08132155,-0.050994504,0.03988311,-0.040753834,-0.08432297,-0.03362334,0.05660344,-0.019166281,-3.6139e-08,0.07641726,0.029701214,0.15486278,0.06513194,-0.017546015,-0.041794285,-0.011678322,0.08218944,0.040580954,0.028119031,-0.014210241,0.10118546,0.080816366,-0.025383445,0.0069662984,0.04987927,-0.04470554,-0.06461467,-0.0071817795,-0.01581349,-0.028170481,-0.05119407,-0.11332075,0.062191155,0.07762576,-0.056648787,0.06834412,-0.07249308,-0.059174374,-0.05463729,0.18887782,0.005652505,0.03462569,-0.031306017,0.036569834,-0.024417175,-0.07158536,-0.015666114,0.04643372,-0.01937921,-0.05522596,0.024841785,-0.09267982,0.019983485,-0.049902607,0.0486113,-0.04420561,0.054465894,-0.07113074,-0.035305016,0.02681471,-0.0073716994,-0.023918629,0.023255587,-0.023591407,0.06359008,0.13370238,-0.026444098,-0.013509657,0.005800468,0.009913907,-0.036881536,0.11469923,-0.036303785 +1.1.1.261,"This enzyme is found primarily as a Zn2+-dependent form in archaea but a Ni2+-dependent form has been found in Gram-positive bacteria [6]. The Zn2+-dependent metalloenzyme is responsible for the formation of archaea-specific sn-glycerol-1-phosphate, the first step in the biosynthesis of polar lipids in archaea. It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes. The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase) and EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase), which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [4]. Activity of the enzyme is stimulated by K+ [2].",384,0.99999994,-0.08545071,-0.055405937,-0.09335427,-0.013818921,0.05052695,0.0043732035,-0.099209964,-0.007006749,0.03421063,-0.030774765,0.016840322,-0.022643218,-0.028894922,0.032278884,-0.031617947,-0.047087736,-0.025233924,0.008219425,0.0022557194,0.010263675,0.12984414,0.085417606,-0.023480937,0.025278678,-0.03796575,-0.008950092,0.017667111,-0.099351615,-0.035039183,-0.0037634165,0.040708497,-0.094647355,0.097576134,-0.053377952,0.06769047,0.066998184,0.0012776499,0.024220217,0.0065602604,-0.007347004,0.075546056,0.0056665866,0.04870956,-0.07288028,-0.011858788,0.008046222,0.07534205,-0.020896953,-0.009402827,-0.0028072374,-0.047896307,-0.10627424,-0.0431658,-0.03741196,0.039925344,0.054534454,-0.061733626,-0.05366825,-0.01853727,-0.037115913,0.06289655,-0.022003064,0.049028225,-0.021989755,-0.011398932,-0.041842762,0.09563026,-0.06838443,0.02664927,0.015376124,-0.07728121,-0.017452095,-0.021007784,0.018104805,-0.064378634,0.09922616,0.021272583,-0.03177443,-0.0023171832,-0.1074262,0.062646,-0.022095993,-0.04318783,0.06744792,0.0119698,-0.037246227,0.024375878,0.05364473,0.029045075,0.029470192,0.05703233,-0.040014934,0.09310929,-0.042221077,-0.016852189,0.040134363,0.025598682,0.011373448,0.01350055,-0.041919056,0.051518477,0.038603336,0.022229327,-0.08625048,-0.006344095,0.020690596,-0.03373711,0.0831827,0.03271022,0.08620177,0.0071928264,-0.016947001,0.057252657,0.012176924,-0.01742269,0.07381311,-0.01302235,-0.030476972,-0.091414586,0.085239105,-0.025239786,-0.0663201,0.036317736,0.05684585,-0.02402395,0.12063596,-0.08165533,4.306484e-33,0.07696491,0.038882237,0.017129036,-0.045048125,0.026823828,-0.012781831,-0.065235205,0.024135666,-0.073977515,-0.025325846,-0.018139767,-0.0370215,0.0642585,-0.029241335,-0.061986476,0.050470255,-0.048031628,0.05063751,0.06669639,0.026786853,-0.034139775,0.0007555223,-0.013040208,-0.07119291,0.058930617,-0.008746921,0.003656036,-0.0668918,0.026090723,-0.034411654,0.049344733,-0.17611334,-0.07574966,0.024189265,0.20117228,-0.059398774,0.018775852,-0.027634196,-0.030499285,-0.018064283,-0.005596873,0.037842255,-0.016367426,0.027125042,0.047706842,-0.011009081,-0.07797701,0.07596137,0.061729945,0.019309668,0.008465375,0.017657725,0.07639133,0.014496405,-0.08589394,-0.031175887,-0.0204066,0.05620639,0.03517966,-0.016124649,-0.004824102,0.07812117,-0.028226854,0.0055391826,0.053563517,0.0449129,-0.07897953,-0.019499943,0.00237368,0.02166629,0.03103107,-0.046200465,0.057574116,0.08256721,-0.010781475,-0.035952456,-0.010559854,0.010386045,0.0016968109,0.02257518,-0.081380434,0.0251502,-0.0126772355,-0.027421417,-0.031220354,0.02959023,-0.04532898,-0.047774747,0.0019115761,0.061262935,0.016254203,-0.03844016,-0.0407957,0.06309436,-0.057422847,-4.8394427e-33,0.0138076255,-0.06410791,0.008027775,-0.061078727,-0.054428346,0.06371271,-0.038968638,-0.005214882,0.05144752,-0.055336904,0.06601886,0.009541883,0.09756277,-0.037434507,0.012247788,-0.041621517,-0.004163243,0.064945206,0.0461068,-0.0052568447,0.098273866,0.0152823,-0.0324505,0.08785147,0.017929843,0.031019777,0.023878314,0.08523525,-0.024579432,0.07860984,0.0322821,0.081980474,-0.10071117,-0.090989456,-0.13006468,0.001122176,-0.07484008,-0.00054077426,0.020261072,-0.0101710865,-0.00039296038,0.049949005,0.04058013,0.005428704,0.042958904,0.019896422,-0.015785582,0.033151347,0.013805399,-0.03468491,-0.052764744,-0.03682812,-0.009807288,0.06166894,0.051390633,0.028902939,-0.008639079,0.12588735,0.0042540887,-0.06825361,-0.055712983,-0.039066344,0.027276615,-0.035186183,0.02199697,0.05693203,0.03340705,-0.0043356987,0.032951288,-0.013199772,0.008182884,0.01902601,0.040134147,0.056946386,0.021516861,0.07719747,-0.006443485,-0.08455016,-0.026071182,-0.088234365,0.011267764,0.062008493,0.03196299,-0.06966452,-0.0065857717,-0.046645302,0.10446298,0.09481666,-0.03436939,0.007418302,-0.020293793,-0.06309014,-0.086827956,-0.0174022,0.00763254,-4.1551807e-08,0.024910735,-0.021253273,0.051460605,-0.04818726,-0.055994246,-0.006627311,0.092319876,0.038972046,0.03690334,-0.09664543,0.015406269,0.022857357,0.047789834,-0.055108607,0.039081044,0.081200935,-0.027055332,0.0064986926,-0.03887159,-0.036334567,-0.0003147155,-0.05614776,-0.06482173,0.067297414,0.008019233,-0.07169486,0.037877616,0.009893261,-0.048608195,-0.052075747,-0.015262804,-0.028241526,0.037934795,0.004654771,0.0025569156,-0.0076060314,-0.08047053,-0.028750163,-0.0126598505,0.026555076,-0.05378301,0.00012621595,-0.08397116,-0.00385716,0.009858508,0.0006322027,-0.01983692,0.09994215,-0.037393976,0.02303482,-0.0075947554,-0.028110135,0.0059543317,-0.11727035,-0.06585035,-0.014122247,0.030773161,-0.0643822,-0.039496817,0.060326304,0.046318144,-0.019020118,0.10543789,-0.034840863 +1.1.1.262, The enzyme is part of the biosynthesis pathway of the cofactor pyridoxal 5'-phosphate found in anaerobic bacteria.,384,1.0,-0.045100875,-0.020164475,-0.10778669,-0.05636909,0.075826526,0.035694428,-0.09268662,-0.02977679,0.03059813,0.049331754,0.024537293,-0.064144775,-0.0691107,0.036638778,-0.036883954,0.0146262245,-0.10349032,-0.045171484,0.004050113,-0.07555728,0.10412015,0.068134256,0.0012981528,-0.008674942,0.024832865,0.03871536,0.050808594,0.00741022,-0.03520121,-0.030390508,-0.051819004,0.041251734,0.05990891,-0.11200684,0.06470441,0.1340205,-0.049069908,-0.041105326,0.100979365,0.02628793,0.06438779,-0.00830987,-0.014086137,0.021034323,-0.045462504,0.020526923,0.059345093,0.012422703,0.06533242,-0.03662446,-0.108078465,0.0028524408,-0.055389304,-0.07645295,0.018366702,0.013305236,0.07094417,-0.06568674,-0.047041956,-0.03898549,0.052797668,-0.052010566,0.0032911329,0.014794816,-0.037522927,-0.057869483,0.04709302,-0.083041735,-0.023916641,-0.04638493,-0.111517824,-0.066764735,0.03977907,-0.018908305,-0.054566223,0.056768034,-0.00062067143,-0.055993207,-0.020056207,-0.02860033,0.016349811,-0.005532903,0.039518174,0.026775807,0.043814737,-0.026543511,0.03339665,-0.020059614,0.053777013,0.008647604,-0.0016693865,-0.00941281,0.025893915,-0.034237646,-0.06873177,0.013700552,-0.011123047,0.045899145,0.03102416,-0.081705555,0.0037248505,0.03929725,-0.0068016034,-0.0143355895,-0.03402624,-0.021522837,0.029193318,0.107053794,0.036302056,0.02374625,-0.07070961,0.06525812,0.03215914,-0.009010698,0.039038796,0.06597137,0.010202682,-0.027673205,-0.0635139,0.08755904,0.006452235,-0.096574135,0.0033134737,0.07049234,-0.058413222,-0.048129994,-0.10706616,1.3590994e-33,0.06576625,0.07573767,0.020008828,-0.009220069,0.00995604,-0.015401727,-0.089293785,-0.072865956,-0.031419296,-0.03651526,-0.0039665196,-0.06248605,0.058560368,0.0124349315,-0.0876663,-0.027147982,-0.09291811,0.015363437,0.032439046,0.03352684,0.038916092,0.081754684,-0.057796225,0.035643954,0.027979126,0.07544242,0.009140543,0.002128686,-0.00457443,-0.009536076,0.021935536,-0.09854292,-0.07373084,-0.030421704,0.08055874,-0.052737385,-0.026697474,0.013485177,-0.062201634,0.031781707,-0.0140388785,0.024181213,-0.0022920924,0.02273916,0.008626634,-0.038202114,-0.06689924,0.09706993,0.050857384,0.07560543,0.00854092,-0.02460732,0.12367833,-0.011671211,-0.07336172,0.014033429,-0.013396624,-0.0028316292,0.023898717,0.021161783,0.05373333,0.028347237,-0.02876825,0.05120189,0.0073679793,0.0011264208,0.029847108,-0.045100823,0.10820637,0.12890813,-0.057049405,0.0089827245,0.02148949,0.08623912,-0.010057443,-0.023596937,-0.06475517,-0.029999532,-0.036023375,0.00078831904,-0.024891796,-0.04403109,-7.61583e-05,-0.06775947,-0.035566498,0.019981323,-0.048419677,-0.017890375,0.00013760809,0.0046444517,0.07298243,-0.071443155,-0.020669559,0.043691825,-0.018608976,-2.635098e-33,0.12743406,-0.082948394,0.05781473,-0.09509064,-0.0851846,0.050919164,0.043712255,-0.01288788,0.016502911,0.028946174,0.028985612,0.035083383,0.03133406,-0.0028273198,0.029621199,0.005493187,0.03933117,0.069874056,0.016409209,0.030871425,0.024926685,0.036026977,-0.007652002,-0.025604883,0.061598904,0.095213905,-0.025119875,0.04663512,-0.03739149,-0.00476616,-0.03330442,0.020945506,-0.030244375,-0.07628478,-0.042584762,0.019250179,-0.09331473,0.038562573,-0.017127058,0.0021753935,0.031377967,0.07384446,0.014685506,0.011026857,-0.030787172,-0.012866973,-0.032924738,0.036520638,-0.020268345,-0.066940315,-0.0011030709,0.03056293,-0.036386877,-0.038729325,0.037893683,0.051509976,-0.004009122,0.027789012,-0.0074412646,-0.0003030354,-0.0454579,-0.011817004,0.06887084,0.039038215,0.034240767,0.09229584,0.04219469,0.06372904,0.032609932,0.041256197,-0.0031517243,0.10143809,0.019384531,0.093595564,-0.07781984,0.0030885835,-0.08055678,0.011303646,0.023858797,0.051244207,-0.005453078,-0.034389406,-0.022130325,-0.070714585,-0.07946995,-0.11392939,0.06532407,0.07759611,0.06384158,0.0020167097,0.0026894244,-0.049819835,-0.013897429,0.03247485,0.015647078,-2.7180887e-08,0.031199919,-0.04770283,0.07737262,-0.003998941,0.03279131,0.043485418,-0.010486396,-0.060099803,0.10647334,-0.010282184,0.026651634,0.0042202673,0.03522854,-0.0024370444,0.005389479,0.04026429,-0.06564287,-0.013181481,0.011185008,-0.0101662995,-0.061055962,-0.029957963,-0.12286427,0.07413636,0.1013063,-0.032156684,-0.013781004,0.030789247,-0.025933636,-0.021356482,-0.02644463,-0.004103186,-0.009543944,-0.04146033,-0.075226635,0.04485274,-0.019007029,-0.061465137,-0.054266445,0.02029168,-0.0053617563,-0.06307413,-0.049134478,-0.0016343383,0.011050601,0.09276941,-0.037738167,-0.015768802,-0.023797298,-0.047327053,0.022581767,-0.021208284,-0.038438424,0.0054842792,-0.11952621,0.040294163,0.030507697,-0.05723156,-0.03252896,-0.038977325,-0.01089737,0.029947042,0.18203142,-0.094022945 +1.1.1.263,"Also reduces pyridine-3-aldehyde and 2,3-butanedione. Acetaldehyde, 2-dehydroglucose (glucosone) and glucuronate are poor substrates, but there is no detectable action on glucose, mannose and fructose.",384,0.9999999,0.04321753,-0.0030828922,-0.03030213,-0.023079624,0.07340337,0.05472666,-0.039957035,-0.008713908,0.029364958,0.04067492,-0.00438718,0.024053533,-0.09128094,0.03194561,0.010456703,-0.028238073,0.013931756,0.05399601,0.013233628,-0.054246064,0.09110603,-0.08908519,0.08117052,0.013243203,0.03375939,-0.0418532,-0.016667083,-0.02121648,-0.06306221,-0.043622155,-0.04109614,-0.0315436,-0.030034862,-0.056115635,0.07495905,0.10740377,-0.07803394,0.048135404,-0.006581016,-0.029916639,-0.02790313,-0.08622221,-0.04889828,0.043164108,-0.049219962,-0.045406237,-0.033669166,0.033658784,-0.08183666,-0.018102914,-0.00070548314,0.046050984,-0.014825661,-0.026249679,0.049939487,-0.030198267,-0.058318026,0.018994804,-0.062407658,-0.043762516,0.004407666,-0.02870638,-0.07840406,-0.037928022,-0.014557839,-0.019559829,0.06739715,-0.076555185,-0.010525983,0.019310597,-0.0209714,-0.029315872,0.015375386,-0.01895897,0.09269613,0.015508856,-0.07705317,-0.051555403,0.01074351,0.039786983,0.07519532,-0.016069394,0.06459761,0.07672266,0.027268954,-0.07105958,-0.011706494,-0.028605618,-0.084537685,-0.04287708,0.025301358,0.011839286,-0.022870159,0.059496913,-0.05865798,0.049243037,0.031921618,0.010852924,0.029039416,-0.01798434,0.003950081,0.024930717,-0.041313503,-0.047809858,-0.08642594,0.048601557,0.03984032,0.009384517,0.0071229357,0.0017499456,-0.041020088,0.047106236,-0.045646746,0.04940777,-0.11680545,0.062979266,0.11415813,-0.054704875,-0.046647184,0.0051530222,-0.0069353012,0.024398562,0.07809802,0.012378715,-0.017389098,0.05116635,0.010131107,5.4716907e-33,0.010655516,-0.0025590402,-0.02347935,-0.06540614,0.10068594,0.07212765,-0.07216264,-0.013108773,0.02335162,0.02068672,-0.030099077,-0.027232993,0.031739533,0.039871186,0.0033611595,-0.0067661367,-0.059151154,-0.009290032,0.10743622,-0.04861737,-0.03051981,0.025915122,-0.0111487135,0.048633732,0.041426755,0.03455742,-0.04456492,0.072329246,-0.03639661,-0.023191923,0.036211886,-0.05374016,-0.043507718,-0.035583712,0.0028679688,0.026906595,-0.13354617,-0.026460972,-0.024599507,0.0071883504,0.0040269843,0.042455178,0.038468752,-0.07946177,-0.008536231,-0.029251862,-0.012878948,0.07327925,-0.047809612,0.109745294,0.110476226,-0.00770937,-0.018240353,0.029485337,-0.022033466,0.052378032,0.0043943827,-0.075867854,0.03385934,0.004493294,0.0013433262,0.013813936,0.020902326,-0.056362353,0.009429357,-0.032764785,-0.025859652,-0.026809353,-0.0723827,-0.0073016365,-0.035237864,-0.02258698,0.053962927,0.011340731,0.029874943,-0.017535988,-0.057960525,0.035704203,0.014406448,-0.0689145,0.06221529,-0.012479808,0.065555684,-0.011303691,-0.092615716,-0.017882645,-0.088326074,-0.050387025,0.043494284,0.004852443,-0.09014922,-0.011270377,-0.058216125,0.00076941634,0.020985097,-6.406305e-33,0.060723014,-0.05256541,0.08141892,-0.05730108,-0.014799636,0.014481301,0.10171055,-0.12819725,0.04426808,-0.039088324,0.07624284,0.00829418,-0.018337652,0.018894907,0.029541444,0.051086336,-0.0338717,0.05372278,0.016475447,0.008520137,0.020169068,0.12275906,-0.060523674,0.05449934,0.062111344,-0.014971617,0.043776557,-0.01671435,0.09002324,0.016460493,0.042735405,0.007050107,0.011446038,-0.07941931,0.05610226,9.217633e-05,-0.023647841,0.042361747,-0.10766798,0.018413654,0.038708687,0.09942455,0.02356607,0.0041069794,0.07497108,0.07450184,-0.0678868,-0.020048622,-0.014402545,0.01409509,-0.023068024,-0.021511938,-0.0832006,-0.014961517,0.12305246,0.049832445,0.045157265,-0.12933993,0.009471351,-0.020231403,-0.051858887,0.008262659,-0.016075132,-0.009587204,0.08610126,0.05335687,-0.012971706,0.054140426,0.102987304,0.07478283,0.07161014,-0.014624154,-0.03752698,0.009552944,-0.073437154,-0.007897926,-0.045590546,0.05310699,-0.01965411,-0.0150257,0.060995344,-0.01961505,-0.024207741,-0.113087304,-0.04796015,-0.07619043,-0.021448916,0.05076208,-0.055847257,0.07997149,-0.0155094685,0.0100649595,0.03928243,0.011206621,0.0675774,-4.0262595e-08,0.049666733,-0.015756931,0.057413775,-0.042808946,-0.09189705,-0.075472206,0.080949835,0.120761104,0.0050583836,-0.053099755,-0.01979645,0.0792978,0.033718675,0.010753821,0.044831656,-0.023272315,-0.012680314,0.0112221455,-0.030518144,-0.032150302,-0.1339608,0.037037063,-0.10882326,0.0018875952,0.022203658,-0.062068827,0.0945969,-0.0046763383,0.022165086,-0.017487228,0.06287132,0.056146957,0.10028227,-0.03713941,-0.02144086,0.005854256,-0.0003921197,-0.0075646476,-0.040589374,0.019392207,-0.07009036,-0.01364226,-0.047531195,0.00480728,0.014821726,-0.044590205,-0.008619995,0.006274858,-0.040059,0.07080891,0.02916744,0.051508795,-0.042018775,-0.028270483,-0.07840237,0.023225728,-0.0024812412,0.0057396386,0.0044186213,-0.11692865,0.03613903,-0.045792703,0.14862023,-0.045617007 +1.1.1.264,"The enzyme from the bacterium Escherichia coli is specific for 5-dehydro-D-gluconate. cf. EC 1.1.1.366, L-idonate 5-dehydrogenase (NAD+).",384,1.0,-0.102463245,-0.047012832,-0.017647315,-0.08214795,0.021623917,0.009477094,-0.09243174,0.045259416,0.0070125163,-0.006562524,0.017028688,-0.027262522,-0.1486357,0.041906577,-0.046193678,-0.022109814,-0.005706247,0.01939677,-0.03603568,-0.09480396,0.09627357,0.06490871,-0.017331226,-0.061679192,0.07022117,0.021823673,0.0506445,0.057228334,-0.039464917,-0.07574296,-0.0074223564,-0.020592716,0.054371282,-0.04791893,0.046841722,0.0745786,-0.0784266,-0.06746872,0.105255134,0.041779157,0.011854853,0.014701154,-0.0022004526,0.015312204,-0.046388227,-0.030211108,-0.023047578,0.10608897,0.0073934826,-0.021128835,-0.012248503,-0.050628282,-0.018548097,0.004150917,0.054836337,-0.023939691,0.040369254,-0.0511907,-0.054042794,-0.008179504,0.025954308,-0.017893028,-0.008162649,0.004001606,-0.02724356,-0.035792068,0.08562002,-0.09585756,-0.02652691,-0.06166596,-0.0537042,-0.07053912,0.059526205,0.07668722,-0.04847663,0.041466095,-0.049594216,-0.059071578,0.033467174,-0.013794644,0.07097059,0.028872961,0.03463886,0.041456956,0.029294763,-0.021247957,-0.0038161862,0.050677113,0.058196746,-0.044093493,-0.0077493726,-0.05677288,-0.07840462,-0.014180857,-0.07625161,0.03679444,0.0069606532,0.0453915,0.048287876,-0.090564705,0.020245634,0.07776591,-0.002808545,0.028321708,-0.016917821,-0.013742261,0.050978746,0.15831654,-0.0756444,-0.08419825,-0.032804366,0.02143369,0.043202143,-0.010692542,-0.023433274,0.011002243,0.07728671,-0.05199808,-0.071498916,-0.040612068,0.0591319,-0.029880319,0.05198836,0.028112797,-0.07761258,0.081051596,-0.12940271,-7.6249033e-34,0.072187625,-0.011614239,0.016095832,0.017370164,0.027580412,0.00084512134,-0.08830004,0.023266247,-0.04947781,0.025348658,-0.060785122,-0.039916046,0.038264778,-0.0011661368,-0.01836864,0.09729924,-0.028706772,-0.02140449,-0.009734043,0.042166773,0.06495501,0.07478246,-0.0544184,0.017700557,0.045521967,0.09997986,0.009269395,0.023162723,0.05086034,-0.015631866,-0.0486571,-0.14640777,-0.058041167,-0.028488223,0.07509501,0.005629095,-0.06168908,0.036095444,0.022058628,0.02576017,0.026444254,0.047666233,0.0003600774,0.0035135476,0.058014043,0.014036946,-0.0439346,0.032926712,0.01481131,0.06228684,0.057411805,-0.0057016932,0.059120554,-0.05791781,-0.029243082,0.059801765,-0.029640628,0.08720011,0.018798586,0.13038664,-0.018977206,0.077594414,-0.056005254,0.04921189,0.011726828,0.014143881,-0.032402467,-0.030981947,0.04365217,0.12538849,-0.033755563,-0.010035153,0.099112,0.0519212,0.015442734,-0.04552865,-0.016219443,-0.011215857,0.005457791,-0.032512244,-0.007635084,0.021819273,-0.024045806,-0.012509188,-0.08397026,0.054127563,-0.027969403,-0.023213739,-0.034901783,0.03356918,0.0368688,-0.060847305,-0.016450576,-0.01370884,0.0057214494,-5.818385e-34,0.0886897,-0.0686636,0.050645005,-0.076336764,-0.057230696,0.103648864,0.034468487,-0.07320528,0.006309936,0.01904883,0.083274096,0.086836256,0.0006666452,-0.008098467,0.009072334,0.04390929,-0.115804516,0.0022423873,-0.026588919,0.017496804,0.07012133,0.08171554,0.03764658,-0.034587994,0.093978286,0.02159967,0.023099752,0.056316186,0.021730047,-0.018944196,-0.04125365,-0.004826373,0.0022326885,-0.050699007,-0.043964982,0.04290142,-0.04810094,0.020162584,-0.027536942,0.029993119,-0.046665255,0.05264835,-0.0037744357,0.04969819,-0.012667534,0.06676253,-0.07355314,-0.009621172,0.06133746,-0.045208685,-0.009423219,-0.039250113,-0.037311364,-0.017994966,0.016319916,-0.0064686732,0.04839219,0.032533333,-0.013708689,0.039808877,-0.008635997,-0.040684182,0.086032435,-0.008544731,0.035359204,0.012766613,0.0049114823,0.034900613,-0.0013377588,-0.00050366845,0.041972425,-0.0026365086,-0.017392894,0.03542174,-0.033349052,-0.054500233,-0.09208301,0.012999841,-0.0017872085,0.020918053,0.027786363,0.0032128706,-0.06406622,0.034594096,0.02259548,-0.08754414,0.04662764,0.11816933,0.022819992,0.075321764,-0.018633073,0.021241508,-0.064025104,0.024757164,0.0058468203,-3.1484777e-08,0.044059902,-0.045677673,0.005009307,-0.080705576,0.02985013,0.030865973,-0.038170796,-0.033848036,0.121829644,0.04685556,0.035527106,0.09532053,-0.016901543,0.06661307,-0.02111449,-0.02934431,-0.0747941,-0.056950334,0.0069168345,0.015425063,-0.02856137,0.017405795,-0.1344567,-0.029231641,0.04088729,-0.091797516,0.00650099,-0.011964105,-0.009140256,-0.025921367,-0.036023334,0.0414121,0.019698914,-0.040568568,-0.033304274,0.04779621,-0.072827056,-0.025437443,-0.053743385,0.046200838,0.014619854,-0.06610367,-0.041968014,0.02235143,-0.01905804,-0.00052444125,-0.026296731,-0.018951649,-0.0066656587,0.06902037,0.013933009,-0.056975793,0.031223688,-0.03290519,-0.11798279,0.016687633,-0.03363363,-0.080351286,-0.009360358,-0.0502884,0.034878034,-0.0043567345,0.15244956,-0.024229761 +1.1.1.265,"The enzyme purified from Saccharomyces cerevisiae catalyses the reduction of a number of straight-chain and branched aldehydes, as well as some aromatic aldehydes.",384,1.0,0.013431445,0.0037080902,-0.022416547,-0.016244497,0.06338195,0.02416614,-0.06747417,-0.05837526,0.07741099,0.014336579,0.018217128,0.0410445,-0.06821766,-0.028064571,-0.09809947,0.014328537,-0.09672228,0.045012612,0.0023303921,-0.050266877,0.030872084,-0.0035964423,0.0034263695,0.045700535,0.052193515,-0.045515016,0.031696,-0.009040782,-0.025397807,-0.10615925,0.03848736,-0.014348743,0.02215522,-0.053517066,-0.012817937,0.029614268,0.01932796,-0.0076331394,0.03575775,-0.0012076984,0.019142965,-0.041536715,-0.0759028,0.009816691,-0.06049951,0.07856135,0.0076271365,0.0059318603,-0.015712785,-0.010926671,-0.025415938,-0.051672697,-0.060065873,0.011669966,-0.0013609617,-0.00093374896,-0.02839799,0.022934759,-0.003087058,0.056654304,-0.005487141,-0.052443817,-0.07112426,0.037141424,-0.023539396,-0.073461115,0.079545476,-0.002630774,0.034968488,0.013680911,-0.033855427,-0.070335075,-0.06550675,-0.034192372,0.09102621,-0.009771713,-0.028001895,-0.07503637,0.049744245,0.009521024,0.012974853,0.0028444172,0.0430368,0.051884912,0.0119120935,-0.054603115,0.048992623,0.021491623,0.030962529,0.010191697,0.021597533,-0.008468682,0.020836461,-0.0208335,-0.03997797,0.064608745,0.042018097,0.083588175,0.073268175,-0.01918326,0.045433722,0.010713191,0.015189439,-0.11723651,0.012937793,0.091076225,0.053051088,0.08530054,0.04100827,0.0019556978,-0.0130566135,0.020246891,-0.008731483,0.028250061,-0.043859664,0.048861846,0.08102097,-0.04807309,-0.051583853,0.012098953,-0.021099323,0.06767773,0.0496578,0.042796053,-0.10588551,0.09201387,-0.07781781,2.6208526e-33,0.018528529,0.05917352,-0.068426974,-0.044074643,0.07218298,-0.017250115,-0.07787255,0.026744297,-0.020936714,0.026084615,-0.036448255,-0.06731271,-0.018486848,0.033670478,0.013982793,-0.07574276,0.06648078,-0.026942499,0.034086626,-0.0276617,-0.04204271,0.019383876,-0.07200754,-0.008994785,0.066956766,0.013876577,-0.024613805,0.068358466,-0.05390964,-0.031549197,-0.0012132144,-0.06505558,-0.083383165,-0.013075119,0.049922287,0.026040774,0.017299244,-0.044684026,0.013617043,-0.020945206,-0.0021632044,0.01124726,-0.0023255078,-0.04903014,-0.014045535,0.03976616,-0.044443462,0.065085515,0.0090396805,0.11679709,0.023684464,-0.010452503,0.08520449,-0.0014027545,-0.08155064,0.093745574,-0.032963835,-0.011951468,0.024934815,0.023074256,-0.063822344,0.079729766,0.005000604,0.019776199,-0.021145647,-0.021049172,-0.019776935,-0.008808363,-0.011993729,0.026144797,-0.13353793,0.018917141,0.036603328,-0.056382436,0.023953782,-0.010720725,-0.12669827,-0.057343572,0.029576048,-0.0057407594,-0.06496391,-0.002245622,-0.0229251,-0.037501503,-0.025528092,-0.012985433,-0.044990815,0.028591404,-0.010707516,-0.014036279,-0.037741225,-0.08468097,0.029250547,0.053307448,0.023518562,-5.1980533e-33,0.102171436,-0.08728418,0.07872406,-0.07510261,-0.08384847,0.052816518,0.014961447,-0.039622273,-0.046637803,-0.027787857,0.052885335,-0.033079807,0.031548977,-0.018163716,-0.0036998517,-0.010155969,0.0075463303,0.057189394,-0.0070415395,-0.0632692,-0.0035351855,0.11004859,-0.019862607,0.020918256,0.035020456,0.0022417218,0.05233242,0.10824942,0.14127952,0.025752746,-0.018825324,-0.03724205,0.033181336,-0.059066318,0.01298394,0.057831742,-0.025132865,0.0787137,-0.00032671937,0.045218438,0.077614024,0.050466105,-0.08411304,0.06301241,0.038027633,0.10043741,-0.08510842,0.044549398,0.0381621,-0.11702464,0.044644635,0.0387059,-0.005139629,0.037491113,0.040593337,0.01566564,0.018898638,-0.06918178,-0.018356772,-0.071073204,-0.12042668,-0.07410213,0.04822682,-0.017545909,0.015860561,0.012362609,-0.043017708,-0.0024315913,-0.035666227,-0.02764453,0.041643605,0.067251965,-0.053684946,0.051215142,-0.0029288384,-0.028285103,-0.06728623,-0.07879523,-0.0010974754,-0.029173432,0.025662936,-0.045265365,0.025370141,-0.07548652,-0.008827665,-0.10293798,0.015832445,0.044232324,-0.03774852,0.048411306,0.041079957,0.0068389494,-0.006220104,0.09421522,0.01945458,-3.2295183e-08,0.04470435,0.019728458,0.057097398,-0.060671765,0.0005203616,0.030143112,0.029637143,0.09706385,-0.019674722,-0.037225835,-0.082586385,0.06033084,0.00057593244,0.11704619,0.069242135,0.004589784,-0.094973624,0.0203957,0.0011254175,0.0018325206,-0.043652624,-0.012215103,-0.09910468,0.09762958,-0.00044210587,-0.031929184,0.055913996,0.027559627,-0.0065929554,-0.015064377,0.0010302674,0.12289016,-0.047629654,-0.021459406,-0.048383582,0.03518816,-0.046127584,-0.062516645,-0.011732219,0.05275572,-0.032541383,-0.078085855,-0.05425593,-0.0014907668,-0.048020843,-0.0636902,0.04214215,0.0109453155,-0.00053961755,0.041561928,0.096433565,0.027602741,-0.00035735194,-0.0160418,-0.08796479,-0.037283566,-0.0305595,-0.06330118,-0.03772529,-0.08528159,0.05862404,-0.039010696,0.1887359,-0.080860004 +1.1.1.266,"The enzymes from the Gram-negative bacteria Aggregatibacter actinomycetemcomitans and Escherichia coli O52 are involved in activation of fucose for incorporation into capsular polysaccharide O-antigens [1,3]. The enzyme from the Gram-positive bacterium Anoxybacillus tepidamans (Geobacillus tepidamans) is involved in activation of fucose for incorporation into the organism's S-layer [2]. The enzyme from Escherichia coli O52 has a higher catalytic efficiency with NADH than with NADPH [3].",384,1.0,-0.058840625,-0.108625285,-0.08908023,0.007539546,-0.025101496,0.033649664,-0.029462982,0.07357174,0.09105253,0.04119732,0.015664581,-0.029601114,-0.014820176,0.05047421,-0.015495905,-0.005541118,0.02650233,0.027950147,0.021967517,-0.049636547,0.06510982,-0.023299143,-0.020177895,-0.085846305,0.011775835,-0.050268702,-0.063292116,-0.030641662,-0.044026166,-0.07525813,-0.021209614,-0.062226195,0.07047348,-0.04077848,0.035327595,0.043789793,-0.03927578,0.010736289,0.085024424,-0.044571836,-0.05968662,0.006947582,-0.011611794,-0.05637203,-0.05300627,-0.052294593,-0.005240273,0.069330476,0.0620434,-0.052106988,-0.07247146,-0.034394387,-0.06837172,-0.028015286,0.038151566,0.021485854,0.026447896,-0.11445985,-0.049399447,0.013296157,-0.013382873,-0.012983648,0.026617786,0.034126475,-0.002675041,-0.09120261,0.10028162,-0.026134843,-0.04445114,0.010602405,-0.11489104,0.036022842,0.043890074,-0.042975113,0.019024942,0.07100568,-0.01660806,-0.021105785,0.034748506,0.059801765,0.026217557,0.025541486,-0.0033955711,0.1112404,-0.0059357327,-0.062240127,-0.032099336,0.03914167,0.029880956,0.049708672,0.04225873,0.0051491642,-0.0009497731,-0.034030147,-0.08417091,-0.04696254,0.01936046,0.026827846,0.07276722,-0.04520871,-0.07428273,-0.010621097,-0.0062753847,-0.10307603,0.0035748747,0.008161802,-0.022660205,0.097453095,0.07279577,0.013200506,-0.021135084,-0.024192616,0.0165832,-0.074728586,-0.10305939,0.072475776,0.047709912,-0.041504458,-0.05222544,-0.019677032,-0.052951496,-0.020305308,0.015081321,0.021688767,-0.024107391,-0.016520308,-0.07804882,4.33417e-33,0.037435938,0.028081952,0.023037545,-0.0058532786,0.01901009,-0.007303383,-0.00041874536,-0.02202211,-0.013713094,0.050122853,-0.08990351,-0.057378035,0.0412382,0.04189239,4.447671e-05,0.06382289,-0.039124783,-0.09466411,-0.050732214,-0.017582243,0.0077684866,0.009730769,0.06213379,-0.044410467,0.04035586,0.048137754,-0.07281821,0.010962659,-0.05260334,0.013876036,0.03369478,-0.07351934,-0.13853332,0.040891755,0.15143895,0.02039894,-0.090418465,-0.031035258,-0.0028109304,-0.032505017,-0.03642814,0.101967394,-0.055384748,-0.061183274,0.042058386,0.037161425,-0.046364322,0.10666455,0.06654681,0.15056959,0.09753496,-0.01956368,0.06850154,0.007987226,-0.0149067305,0.042803686,-0.028928008,0.051788338,0.008114943,0.10107809,-0.008989255,-0.008769578,-0.03519949,-0.016304988,-0.01654733,0.028200366,0.015085717,-0.00082953204,0.053992674,0.057199646,0.008936068,0.04395118,-0.013842819,0.039312854,-0.019677939,-0.05678798,-0.0020197066,-0.039971456,0.0434166,-0.029043257,0.07761307,-0.040344045,-0.00570657,-0.073889926,-0.073474124,0.028183779,-0.021891676,0.02675816,0.016181668,0.106702186,0.04931805,-0.08980818,-0.053641994,0.06593299,0.042328387,-6.5314095e-33,0.0696,-0.07815506,0.031768832,-0.13369851,-0.08944755,0.038653634,0.04428615,0.007414658,-0.03910785,-0.005433133,-0.006721319,0.07896498,0.040905014,0.038801007,-0.029394398,-0.021605972,-0.025168939,0.0235774,-0.018002473,-0.005718621,-0.048826057,0.10076396,0.046642408,-0.013761898,0.047539033,0.0061449874,-0.05109608,0.079001375,0.009203854,0.04468088,0.057472005,0.076902285,-0.046100356,-0.040355425,-0.02477361,-0.04947025,-0.019720107,-0.008258399,0.10676837,0.00838888,0.022191204,0.062924586,0.043490835,0.024290737,-0.016082421,0.09125634,-0.07958217,-0.042219087,0.0037126227,-0.06855963,-0.023544885,-0.023672722,0.0046062553,-0.015926288,0.019086236,0.013633741,0.039576672,-0.07764355,-0.035367034,-0.087025955,-0.038486328,-0.055593893,0.03760599,-0.013664266,0.05124154,0.082863264,0.07315008,0.002157179,0.051045712,-0.018466277,-0.0016597556,0.011229944,-0.05827886,-0.041385107,-0.031239582,-0.004531746,-0.086947314,0.017532056,-0.011055923,0.028561888,-0.018495277,0.048027117,-0.009773189,-0.034992784,0.038570963,-0.038556382,0.032138184,0.07459373,-0.013504955,0.034010362,-0.0072977254,0.05940802,0.029242253,0.05477073,0.059052203,-4.490001e-08,0.05095112,-0.054644607,0.030973209,-0.033786062,-0.07493497,0.098495714,-0.019357396,-0.019866357,-0.002080006,0.015497859,0.023844235,0.14222355,-0.0020330728,0.026367048,-0.006371252,-0.013408787,-0.08021745,-0.018947693,-0.0017219725,-0.03047093,-0.070899375,0.009490981,-0.08132594,0.07009327,0.003646459,-0.03202418,-0.0038708895,-0.03669845,0.009855646,-0.041560322,-0.052158564,0.049538475,-0.053798232,-0.03639275,-0.08449377,0.0061346064,-0.004486648,-0.064924896,-0.018257733,0.01219919,0.0785116,0.027008478,-0.046557195,-0.017623004,-0.020756062,0.051135164,-0.042565014,0.047700413,-0.037671432,0.045256335,0.051202767,0.0028288327,-0.07679933,0.028585711,-0.12583564,-0.0070945635,-0.018299492,-0.020850873,-0.01739988,-0.025227657,0.0043949303,-0.06378948,0.12883393,-0.06738702 +1.1.1.267,"The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA}). The mechanism has been shown to be a retroaldol/aldol reaction [2].",384,0.99999994,-0.03174773,-0.04917467,-0.06399033,0.044627856,-0.058723554,0.003426641,-0.09416643,0.013433278,0.039564863,0.020220796,0.043182258,-0.044286083,-0.009062112,0.0038241616,0.00016991925,0.042059883,-0.0042518387,0.033229172,0.048529465,-0.011023949,0.08612286,0.05297614,-0.029973624,-0.06600253,0.01784308,0.055473078,0.07656194,-0.000926303,-0.0010012193,-0.037711717,-0.1210433,-0.015184966,0.0057568317,-0.1198849,0.044817213,0.083458655,-0.08246,-0.0075591053,0.062965594,-0.02218931,0.06544617,-0.009987681,0.038784947,-0.08585924,-0.027471261,-0.0545592,0.030137483,-0.010865848,0.0047392827,-0.006152142,-0.03896373,-0.038582988,-0.035154562,0.02427082,-0.019609071,-0.010334929,0.017465943,-0.018289952,-0.027714325,-0.01827731,0.04918368,-0.021967482,-0.0060247276,0.015072821,0.01926161,-0.022691026,-0.011071483,-0.019815294,0.013914108,-0.04698815,-0.023527335,-0.08512589,-0.025886396,0.016104756,-0.06259565,-0.01258814,0.101463355,0.006331691,0.048222125,0.015586134,0.02603763,0.012577903,0.049680214,0.10537119,0.08463801,0.0037509424,0.020093402,0.02575216,0.048344646,0.1085639,0.050235562,0.05154979,0.0030661603,-0.030167105,-0.010172189,0.027175212,0.0013819081,0.00046603766,-0.014317089,-0.041929435,0.0047310116,0.072872594,-0.040954024,-0.04803677,0.030995667,0.030097224,0.033886567,0.057396553,0.015658773,0.011890266,0.044603925,-0.019997276,0.0051050675,-9.191762e-05,-0.017243207,0.08026091,0.044226862,-0.11386413,-0.019919131,-0.013833078,0.04879001,-0.048387263,0.004535317,0.09083001,-0.034784004,0.03792322,-0.05577476,1.4390415e-33,0.10589234,0.05555667,-0.006497552,-0.07663278,-0.0035563016,0.038195252,-0.071023375,-0.012383505,-0.020604849,-0.06250131,-0.10304891,-0.061311293,0.052420467,0.029075857,-0.01526788,-0.095466636,0.0018535891,0.057541244,0.14784469,0.0106802005,-0.013558746,0.06647399,-0.0066406876,-0.006417953,-0.01885174,0.11994322,0.044516135,-0.032073487,0.019224148,-0.007587115,0.024595037,-0.12638763,-0.07145991,-0.055847652,0.11788753,-0.036684234,-0.055831905,0.031239394,-0.041021813,0.072417796,-0.0019806926,0.07126123,-0.06512379,0.0037308708,0.073896326,-0.10485554,-0.036311354,0.04099628,0.015249867,0.04405394,0.037252195,0.019351674,0.022815557,-0.011114843,-0.10302509,-0.003321522,0.015979977,0.06524201,0.001030439,0.017752443,0.022914842,0.025092846,-0.01607287,0.09157539,-0.017127544,0.032393787,-0.083168805,-0.08303236,-0.011685445,0.054977205,-0.064351976,-0.025740549,0.09040234,-0.01779128,0.03060157,-0.026272837,-0.059484906,-0.012936632,0.04934621,-0.009594152,-0.0032888276,-0.024491368,-0.012820106,-0.032304507,-0.009519655,-0.0077902316,-0.03468538,-0.019420758,0.02561052,0.0071319793,0.0660737,0.006098874,-0.10857075,0.053705968,0.017675295,-3.4479747e-33,0.07403563,-0.1079666,0.074408375,-0.11139221,-0.09881615,0.029731356,-0.04712651,-0.08169563,0.024442038,0.044952266,0.096973374,-0.02782578,0.061124183,-0.0213524,-0.011189927,-0.041196313,0.006185416,0.096561864,-0.027374534,-0.0869127,0.071280986,0.061597854,0.00862087,0.0030811247,-0.016882403,0.00848569,-0.041464787,0.01940076,-0.016589418,0.09138897,-0.0014004755,-0.023563271,-0.02737095,-0.034717236,-0.036850564,0.12710734,-0.10188447,0.025666341,0.06296304,0.067885906,0.028863234,-0.038086277,0.0155862905,0.058007974,-0.019789113,-0.017910711,-0.10654031,-0.02198825,0.026367906,-0.07787008,0.04551445,-0.007047344,-0.034819428,-0.03126955,0.010010693,-0.0051547894,0.00041237238,-0.026728334,0.060915418,-0.03834731,-0.03172752,-0.07174201,0.08821842,-0.07471705,0.0328458,0.07096038,-0.023665559,0.044111326,0.027637193,0.0062096925,0.053623043,0.09316628,0.024530783,-0.0068457094,0.016905092,-0.0035336975,-0.030950274,-0.09057764,-0.005019382,-0.054509792,-0.026320629,0.0225439,0.0063744793,-0.060425036,-0.060056984,-0.07782256,0.048424013,0.06961403,-0.05376924,0.05540144,-0.018371142,-0.06502049,-0.032885242,0.06830894,0.03737673,-4.20279e-08,-0.07052096,-0.056152556,0.027764034,0.019281426,-0.00275878,0.07775113,-0.047612783,-0.07046435,0.09892532,-0.030319296,-0.0027908888,0.05136499,-0.0031001973,0.041906115,0.086516015,0.027887478,-0.01588745,-0.023654472,-0.014477363,-0.07956996,-0.027036574,-0.0324172,-0.09666636,-0.013481409,0.028181264,-0.052163817,-0.02202689,-0.0072258334,-0.0011763205,-0.07478717,-0.007086744,0.008045336,-0.0552143,-0.023226732,-0.077049725,0.07638956,-0.046935722,-0.03924559,-0.069100745,0.006738042,-0.028115986,-0.028164474,-0.090455875,0.041908458,-0.026334029,0.024751501,0.012805409,0.053720765,-0.08955504,-0.012248008,0.015846113,-0.08456905,0.005590854,-0.0010729737,-0.028076082,0.030373238,0.05188848,-0.0565848,-0.06813267,0.004144242,0.040165316,0.037449215,0.15206991,-0.032571066 +1.3.1.88,A flavoprotein. The enzyme specifically modifies uracil16 and uracil17 in tRNA. ,384,1.0,-0.0609306,-0.015535336,-0.09126392,-0.026165983,-0.012052293,-0.031604473,0.010721668,0.0061189155,-0.00936602,-0.015369563,0.02028596,0.014761171,-0.077340856,0.036115132,-0.114948735,0.032886904,-0.08036945,0.008366581,-0.02574176,-0.06655072,0.022149276,0.072205715,-0.034089595,-0.005363768,-0.008940954,-0.04165506,0.053567074,-0.05220358,0.0031797339,-0.058524996,-0.0013984054,0.013824665,0.0028711795,-0.053788956,-0.048774067,0.02456062,-0.15483032,-0.06403336,0.043789122,-0.026093354,0.076047406,-0.019472526,0.013981726,0.0046229325,0.019846903,-0.010933194,-0.010761125,0.08728021,0.01924397,0.09243083,-0.037846107,0.011652106,-0.06978359,0.044710748,0.027257973,0.0048921364,-0.11619919,-0.023970367,0.0063458206,-0.021449214,-0.0023735722,-0.04203976,0.049782574,-0.05139523,0.06255732,-0.049220793,0.0125445835,0.024888353,0.028721442,-0.06627365,0.018721636,0.00518372,-0.041304275,0.10167822,-0.0012169327,0.08381446,-0.008672687,-0.011945451,0.049289946,0.016343892,0.05986111,-0.05835491,0.035646845,0.0874881,0.066448286,-0.004214349,-0.022578169,-0.0057153357,-0.03961268,0.10317287,0.08920309,0.028814882,0.002134248,-0.0054437728,-0.027346412,0.02548594,0.005954962,-0.016455136,-0.07404997,-0.032646116,-0.037747152,0.018502608,0.0095262,-0.044891287,-0.07164306,-0.038460545,0.044351414,-0.009679685,-0.001769733,-0.008333613,0.03233602,0.002130451,0.08299248,-0.03925967,-0.011523835,0.030026656,0.0005216467,-0.0103124585,-0.016208265,0.007325154,-0.046437785,0.08218642,0.033308353,0.045847207,-0.04572426,-0.017056959,-0.07814619,1.33408305e-33,0.01746333,0.031272836,-0.045680687,0.016648468,0.06622676,-0.023966907,-0.016810453,-0.015404942,-0.045414913,-0.10763456,-0.12837179,-0.041025396,-0.0093094865,-0.09248935,0.0055903257,0.00715837,-0.014938245,0.012778088,0.035219993,-0.07055745,0.018656157,0.12143334,-0.009571301,0.010492604,0.04086022,-1.6526263e-05,-0.018051038,0.004920327,-0.008815148,0.009657457,0.00088087685,0.02877494,-0.069261126,0.013143743,0.0879098,0.026524864,0.012118745,-0.098696835,-0.12927116,0.033110514,-0.028734908,-0.011468895,-0.03051562,0.0021727222,0.0029748168,-0.070262976,-0.07770193,0.048403382,-0.077678114,0.07553448,-0.020138733,-0.021741915,0.071538575,0.017327987,-0.07261902,-0.028929438,-0.04393617,-0.069591574,0.059064087,0.039853435,0.0049287826,0.093696654,-0.038363386,0.06362527,-0.06246165,-0.025850475,-0.023635805,-0.082115464,0.009396293,0.07556011,0.061303705,-0.03100199,0.09602012,-0.022014866,0.014020194,-0.025891809,-0.08286544,-0.019791728,-0.04087573,0.021081557,-0.018080859,-0.040844604,0.05966874,0.051757086,-0.035044618,0.010885417,0.043122787,-0.005762569,0.019981936,0.006241958,0.09025154,0.008418199,-0.061792273,-0.0060535483,0.04556878,-1.7693901e-33,0.11034371,-0.14509797,0.08073944,0.04153159,-0.008830146,0.0020688337,0.06593447,-0.09966127,0.020177685,-0.038185928,0.12308436,-0.07697565,-0.052349504,-0.07671012,0.042971484,0.009817179,0.022936797,0.021810127,-0.043375537,-0.022059537,-0.0530281,0.007378913,0.004400773,0.1034374,-0.010639173,-0.040754043,0.095445946,-0.035757087,0.007807461,0.021762788,-0.038203403,0.0020001421,-0.010345422,0.006924796,-0.03783144,0.07618755,0.027139327,0.022746522,0.026389675,-0.026654897,0.039368898,0.034238517,0.01821482,0.08565817,0.0027061908,0.04284794,-0.017749535,0.018629601,-0.05442097,-0.059689637,0.1510933,0.040618382,0.07190622,0.07315979,0.068112515,0.01914984,0.022523494,0.022395264,-0.02589381,0.04731351,0.004560252,-0.10086478,-0.037302624,-0.015755288,0.09090439,0.0015286305,-0.045182653,0.04263818,0.01928094,-0.020500068,0.03413282,-0.054926362,0.052613903,0.028684359,0.013005992,-0.05865302,-0.028223015,0.035177678,0.0583755,-0.059753332,-0.037219536,-0.013821494,0.007957999,-0.0022515042,0.008244883,-0.0594298,-0.00640093,0.11143802,0.029419415,0.09851571,-0.03779573,0.0135949515,-0.09315452,-0.055717595,0.027883459,-2.3056177e-08,-0.011533095,-0.036599092,-0.042914886,0.029475521,0.03429281,0.07638913,-0.010173313,0.09608077,0.055784542,0.031263556,0.028312529,0.06375317,-0.011187591,-0.0013834481,0.078853205,0.02460966,-0.053641267,0.049832646,0.012145515,-0.029467653,-0.07205883,0.052199844,-0.1508655,0.031487767,-0.018796569,-0.026684547,-0.011565787,0.033495214,0.005171068,-0.04865894,0.029697776,-0.073132515,0.041007154,-0.05702158,-0.10756131,0.08775,0.06155474,-0.07273211,0.010781186,0.08457327,-0.082392655,0.008455131,-0.04605862,-0.04118863,-0.06858115,-0.03686937,0.041502926,0.033427835,-0.0595858,0.017058482,0.051373143,0.023287378,0.08011927,-0.037855953,-0.010485941,0.0080085,0.028044114,-0.06661418,-0.02430937,0.01268814,0.07792739,0.033164505,0.09464124,0.008347721 +1.1.1.268,"The enzyme is highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, 2-(S)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (S)-enantiomer. This enzyme forms component III of a four-component enzyme system (comprising EC 4.4.1.23 [2-hydroxypropyl-CoM lyase; component I], EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.",384,1.0,-0.030285174,-0.06332645,-0.075610444,-0.09497114,0.10250636,0.057040554,-0.10789719,0.06856835,-0.045120124,-0.03461837,0.0057006795,-0.09023007,0.0013131071,0.0147923315,0.05791688,0.034103032,-0.048469387,-0.00043377347,0.0142428065,-0.0353824,0.06784933,0.021591177,0.0032510338,0.05038892,-0.025479542,-0.024777608,0.07549424,0.027911343,-0.108391404,-0.06975526,-0.010414006,-0.045270544,0.011827029,-0.033187207,0.004622777,0.09492349,-0.08256869,-0.044476006,0.07166493,-0.017097125,0.049159314,0.014603676,-0.050363556,-0.044964693,-0.04030654,-0.02249171,0.00443689,0.05353124,-0.010450525,-0.020729002,0.017132835,-0.045223337,-0.012155294,0.030502457,0.017004691,-0.0160836,0.01731442,-0.0018183844,-0.07844189,-0.010018752,0.04908909,0.01628121,0.011035252,-0.0023985137,-0.015618998,-0.0464254,0.056136545,-0.056192726,0.003515038,0.0001695091,-0.12022484,-0.045164492,0.028651245,0.07088105,-0.05813443,0.0039067417,0.042672224,0.008383476,0.029072452,-0.04439144,0.022686694,0.06422667,0.029226637,0.0022906305,0.01399347,-0.060843658,-0.035073448,0.019207947,0.026545255,0.052419886,0.12955445,-0.009399033,0.01668167,0.03279554,0.03906787,0.030757802,0.034072395,0.017376717,0.045886677,-0.05639079,0.026882235,-0.01496303,0.037803683,-0.07579434,-0.00011050376,-0.025716215,0.0044908943,0.09058282,0.01420759,0.019566964,-0.010067734,-0.08389176,0.12274737,-0.017610563,-0.05092322,0.08930795,0.015620673,-0.009685339,-0.00960492,-0.02811159,0.07286161,-0.039149255,0.093637116,0.014318199,0.0007779032,0.0021726077,-0.13187052,1.5259622e-33,0.03859437,0.014994217,0.019695526,-0.016069986,0.027554365,0.05885678,-0.009901595,0.121282496,-0.027224401,-0.020388354,-0.105885886,-0.008307996,0.036221538,-0.027686028,-0.06668023,-0.026222102,-0.059259288,0.0626818,-0.012584313,0.030301297,0.016922094,0.021594936,-0.090256125,0.03400373,-0.071786,0.036163464,0.009979103,-0.05316822,0.016433587,-0.013046884,-0.0038909873,-0.11922923,-0.050974097,0.06774882,0.015230869,-0.07278522,-0.0023979968,-0.02011329,0.02392135,0.005809081,0.064429104,5.0511833e-05,0.017707605,-0.049760696,0.013571931,-0.09298468,-0.07308535,0.087959595,0.031483747,0.06380929,0.07574368,-0.066531554,0.073803484,-0.014136753,-0.046829473,0.0032039424,-0.09118718,0.06094991,0.09502632,0.03644226,-0.0049709207,0.062101036,0.022673246,-0.02313092,0.019862687,0.0063984185,-0.065694176,-0.029658074,-0.060343094,0.08633484,-0.047600728,-0.019054016,0.10597231,0.021844378,0.088313825,-0.054681033,-0.062274802,0.061510906,0.012421887,0.022033831,-0.07627888,0.07655662,-0.011138522,0.017608898,-0.04745215,-0.03736244,-0.022865994,0.029578254,0.012736977,0.09163011,0.06310261,-0.09725375,-0.09527411,0.04745638,0.031802766,-2.349365e-33,0.05021175,-0.038976494,0.06693278,-0.042416632,0.036845673,0.07092866,0.093366325,-0.034565985,0.028059566,-0.018408583,0.10960516,0.037482332,0.014092078,-0.042772144,0.0428652,0.030572778,-0.051086605,0.08358589,-0.049370464,-0.01568731,0.06754465,-0.00038958192,-0.0049227946,-0.004431364,0.027426803,-0.0062348186,-0.014120444,0.015622444,0.10112837,0.088841386,-0.004630643,0.023043681,-0.07826469,0.07163591,-0.09175391,-0.015159308,-0.095542386,-0.006773584,0.0048120786,0.023683755,0.028227229,0.028603641,-0.023787402,0.07454882,0.040825523,0.041019063,-0.07534234,-0.028178668,0.06389292,-0.009375955,-0.063097365,0.02735446,-0.042343825,0.013833104,-0.05239313,0.064264506,-0.022068884,0.004492714,-0.026108006,0.016241692,-0.064257964,-0.028178846,0.04864396,-0.00969354,0.00034662988,-0.026059419,-0.005609178,0.09090566,0.09714705,-0.05890697,0.0692345,-0.035013363,-0.009905775,-0.0083942525,0.020988416,0.010249103,-0.02960082,-0.05388522,-0.0243504,0.010057637,0.07096086,0.014402247,0.035101194,-0.025095882,-0.04219757,-0.0184227,0.027847769,0.093973055,-0.024290498,-0.039434332,0.023989638,-0.022323467,-0.034204286,0.10102462,0.14060989,-4.921759e-08,-0.016405456,-0.08337097,0.06783642,-0.036178164,-0.023714649,0.022618262,0.00925997,0.055567008,0.030985659,-0.056690373,0.027138744,0.011089743,-0.03989816,0.010350162,0.05792468,-0.020201493,-0.021339098,0.06305978,-0.032514412,0.0131693445,-0.0442219,-0.07524889,-0.08161523,-0.010864534,0.011738064,-0.047192115,-0.0002570816,0.0031553104,0.0076145125,-0.022749195,-0.03400266,-0.008322657,-0.012515048,0.03090382,-0.06967295,-0.0022549513,-0.090368226,-0.0032332232,-0.05355077,0.040337153,0.008573697,-0.120611496,-0.055942032,0.010834613,0.082085304,0.013648537,-0.049511537,0.0539559,-0.0038353822,-0.058919743,0.025277194,-0.007985221,-0.0218733,-0.08198617,-0.048768725,0.0723195,-0.052988872,-0.034838144,-0.010617367,-0.032842003,0.003479863,0.07344458,0.16316496,-0.033330694 +1.1.1.269,"The enzyme is highly specific for (2S)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.268, 2-(R)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (R)-enantiomer. This enzyme forms component IV of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.",384,0.9999999,-0.026248151,-0.052645985,-0.064732894,-0.09169258,0.10441068,0.052928094,-0.10422068,0.08329226,-0.048639387,-0.03272404,9.33789e-05,-0.090270914,0.0014481011,0.027985282,0.05802138,0.0357268,-0.049526475,-0.0036748135,0.015365002,-0.027798649,0.06852407,0.032737747,0.0023596238,0.048603892,-0.028286863,-0.009874144,0.072443835,0.03362818,-0.09641297,-0.07115735,0.0013150484,-0.037279647,0.0050997064,-0.03263077,-0.0012329445,0.08526796,-0.080914825,-0.039211024,0.09235201,-0.019089483,0.05409987,0.025027474,-0.045860123,-0.04002177,-0.046624128,-0.028286822,0.000834338,0.060033407,-0.019935038,-0.0145526165,0.008124574,-0.04065579,-0.007522053,0.026952825,0.026753483,-0.013563609,0.0026271576,0.00028988338,-0.082354434,-0.013346766,0.050016955,0.010104056,0.010782414,0.0044698683,-0.028507413,-0.047062617,0.051745992,-0.049768817,0.007884366,-0.004746768,-0.11309436,-0.037440892,0.024218626,0.060995173,-0.05192613,0.0021646994,0.03917431,0.0038592229,0.030376624,-0.050371345,0.024548585,0.060542837,0.027922967,-0.009927298,0.010762928,-0.059595607,-0.011624429,0.0070429323,0.031872924,0.05422728,0.14884046,-0.004784362,0.028613914,0.025266241,0.037871912,0.023871232,0.03801921,0.022966607,0.04980047,-0.052659888,0.024447208,-0.029207835,0.03322971,-0.06369848,-0.014421868,-0.03476271,0.00020643871,0.08065109,0.019279324,0.017973935,-0.004695324,-0.08381608,0.114808604,-0.009111062,-0.056132365,0.09517857,0.0146226175,-0.004127541,-0.0114029795,-0.030806318,0.06421166,-0.04213086,0.09248567,0.009267031,-0.01044831,0.0054203738,-0.14265436,1.684034e-33,0.035710905,0.01496287,0.017042672,-0.018337723,0.03203746,0.051841725,-0.015664155,0.12127335,-0.02401108,-0.015013745,-0.10744975,-0.008475671,0.034872428,-0.032417577,-0.062111504,-0.024678648,-0.063914,0.06901823,-0.0056548254,0.046220496,0.021696469,0.029756935,-0.083409935,0.036617123,-0.07510822,0.032642163,0.022433193,-0.05902077,0.014719758,-0.01228635,0.0042107254,-0.11571773,-0.0477926,0.07292166,0.020121016,-0.07760792,-0.0033419186,-0.023545401,0.028365586,-0.0017841145,0.07082837,0.00017594836,0.015588456,-0.040681154,0.012621252,-0.096878506,-0.06746549,0.09262177,0.030566074,0.072840154,0.065617576,-0.05766618,0.0698943,-0.013584214,-0.03613795,-0.0012991468,-0.09006147,0.061660815,0.09855363,0.036906756,-0.0068078674,0.06723218,0.020182857,-0.026450247,0.018018978,0.0079506915,-0.06694596,-0.05138839,-0.053027436,0.08685802,-0.04017135,-0.024682181,0.10457352,0.019048076,0.0907441,-0.05123899,-0.059681192,0.05695201,0.015469834,0.02228763,-0.081768066,0.08983991,-0.006338303,0.018226052,-0.040854592,-0.04033004,-0.025164865,0.02725068,0.012855479,0.09387558,0.06311703,-0.100340314,-0.10020864,0.04222253,0.0348358,-2.3565725e-33,0.044867497,-0.04355288,0.06465543,-0.030699309,0.034616295,0.06371213,0.10063727,-0.034775358,0.043996297,-0.01836161,0.11988606,0.047046002,0.010270961,-0.029607069,0.04378664,0.023404306,-0.047494102,0.08963459,-0.05380399,-0.0137664145,0.07315613,-0.002610506,-0.0029950452,-0.008639741,0.036875933,-0.0046983133,-0.0015675848,0.017751407,0.106220625,0.085656874,0.0015403056,0.028369883,-0.07838529,0.068121016,-0.08720208,-0.010725034,-0.09239163,-0.014744669,-0.0005597743,0.02833057,0.018964881,0.028475147,-0.022810917,0.076068774,0.030184755,0.020868568,-0.07490395,-0.030218903,0.05914346,-0.014758945,-0.07177681,0.024800299,-0.0438909,0.015704066,-0.06345867,0.057457566,-0.028532108,0.01297644,-0.024818555,0.009045292,-0.057659935,-0.024482979,0.037675757,-0.009577313,-0.0018771674,-0.03260996,0.0012703666,0.08266974,0.091329075,-0.062544934,0.072580956,-0.042167358,-0.002713497,-0.012860454,0.015714373,0.0043925205,-0.03504351,-0.064034715,-0.020849356,0.004831943,0.06165455,0.016121276,0.03749392,-0.025274834,-0.038015757,-0.011039829,0.026270276,0.099938795,-0.029550377,-0.029106412,0.018802961,-0.024999265,-0.03619621,0.09465906,0.13506103,-4.9200743e-08,-0.017884739,-0.094275385,0.06333856,-0.03467515,-0.017815812,0.018703917,0.0024927945,0.04493008,0.031381905,-0.047755044,0.022476787,0.015870634,-0.041461643,0.0129872095,0.05481074,-0.013805785,-0.027271595,0.059026994,-0.03737024,0.0068606297,-0.048559252,-0.078544095,-0.07922019,-0.018256027,0.011395267,-0.052713215,0.001575548,0.001970325,0.005327031,-0.027321784,-0.024537513,-0.0024562285,-0.0026689963,0.024481537,-0.07242699,-0.005399913,-0.079883106,0.005462433,-0.061026014,0.041119292,0.0077334163,-0.12577236,-0.055379786,0.018279398,0.07712155,0.008107079,-0.055701554,0.046781395,-0.0043183696,-0.06300167,0.021704227,0.00283051,-0.030405242,-0.07902853,-0.048864692,0.07068315,-0.061849028,-0.028692905,-0.012274162,-0.024684817,-0.0024022276,0.08239989,0.15882641,-0.04923004 +1.1.1.270,"The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].",384,1.0,-0.02486953,-0.0064873975,-0.10388409,-0.05123855,0.015289647,0.0011476048,-0.042176988,-0.00348791,0.032647815,0.009386051,0.010847249,-0.060594957,-0.10018181,-0.04708409,0.0076805316,0.04127382,-0.06760178,0.012974084,0.03746421,-0.059360016,0.065668896,-0.02963815,-0.023540476,-0.015677271,0.012210279,-0.014268856,0.05510707,-0.0043934463,-0.06914098,-0.05753436,0.049309477,-0.019262468,0.035275906,-0.0013113004,-0.04827875,0.05343557,-0.05847948,-0.11544378,0.024640458,0.05307671,0.062237825,-0.01168819,-0.06909557,-0.06267343,-0.051824693,-0.07099782,-0.07367543,0.055395696,0.025984334,0.026543986,-0.01082189,-0.059971362,-0.018231582,0.02797655,-0.02224698,0.0194871,-0.06394822,-0.0060812337,-0.035938445,0.0357145,0.050891086,-0.008923166,0.0014701546,0.024967965,0.03100393,-0.08681621,0.027487036,-0.054578934,-0.05871597,-0.07784048,-0.041348666,-0.06499172,-0.025796022,0.0016403091,-0.01770675,-0.0013810333,-0.040768415,-0.03795209,0.04937536,-0.063996166,0.011075157,-0.03501167,0.03836735,0.09231275,0.07184731,-0.0145052,0.027801726,0.024399579,0.011944208,0.09548893,0.0018398786,-0.049977314,-0.020739699,0.036207773,0.009333067,0.06334968,0.05017555,-0.010826218,0.025122518,-0.019855551,0.027592503,0.089846134,-0.01553092,-0.06908358,-0.043617766,0.049907964,0.019646283,0.061384372,-0.027289553,-0.013713697,-0.022070678,-0.056061752,0.07033503,-0.0014968355,-0.06780536,0.16621003,0.007635393,-0.07897599,-0.019675761,-0.011599668,0.04145608,0.023002423,0.03582049,0.07670516,0.0014652913,0.08246071,-0.03210972,5.833618e-34,0.071549326,-0.025246117,-0.031110743,-0.016814442,-0.01658991,0.09296724,-0.06524866,0.07543019,-0.049103044,-0.042845685,-0.049795475,-0.038632154,0.11821646,-0.0005717918,-0.021180803,-0.059152294,0.0058349743,0.022067973,0.071844675,0.037674297,0.00535228,0.046989176,-0.08979582,-0.019676339,-0.05048586,0.06445311,-0.07023836,0.045590226,0.026690781,0.010885709,-0.024795271,-0.08025339,-0.087260075,0.043423332,0.059409603,0.028824294,-0.034535453,-0.051376373,0.0036940065,0.047809213,0.03814622,-0.01955036,0.026525298,-0.057512682,0.029985849,0.043968517,-0.024958372,0.03551958,0.12998214,0.044471018,0.010087825,0.0078115333,0.09014181,-0.01076402,-0.008294016,0.1133919,-0.061267506,0.007639892,-0.018322075,0.022489384,-0.059773564,0.07637127,-0.045135703,0.048472136,-0.03032345,0.0412485,-0.051447485,-0.07537361,-0.036693744,0.073709354,-0.067207634,-0.0016840618,0.1007762,-0.022317346,0.02413352,0.079912916,-0.0053300704,-0.011007173,-0.01098254,-0.036063153,-0.053959485,0.055996574,-0.004510995,-0.068608396,-0.0064070188,0.05987328,-0.070981696,-0.07450669,0.050955877,0.053325817,0.044148024,-0.029587422,-0.101049826,0.0012547602,0.013552147,-3.1985536e-33,0.016224926,-0.06541193,0.019422995,-0.121668994,-0.03936628,0.08574144,0.020997657,-0.07407059,0.027027754,-0.002325786,0.024522068,-0.017709801,0.00087971886,-0.106622495,0.06403395,0.040381957,-0.02586287,0.049147192,-0.017729817,-0.052622356,-0.012725962,0.084893525,0.0017485758,0.1168911,0.03504621,0.00932487,0.0520034,-0.030743215,0.09990203,0.036087506,-0.007910573,-0.07126497,-0.025952205,0.025885897,0.025154794,0.0944555,-0.07556753,0.022203978,0.056078706,-0.004116648,-0.07210652,0.013125048,0.054757208,0.025150532,0.074619904,0.067088336,-0.058255434,0.05022862,-0.05730292,-0.044060443,-0.05497585,0.0100417575,-0.016776644,0.011301841,-0.0033200735,0.040345535,0.020406395,-0.027496576,0.055200588,-0.07396772,0.020963525,-0.019406319,0.039579228,-0.007476003,-0.0351273,-0.009391796,-0.017902583,-0.042314187,0.020420851,0.046640314,0.073721156,0.02158778,-0.06476076,0.05190151,0.0017704314,-0.01560104,-0.03427182,-0.08552318,-0.053048864,-0.063772224,0.038222644,0.06985447,0.0031559544,-0.098859884,-0.07529127,-0.09612395,-0.00050499546,0.11178463,0.045147277,0.013289033,-0.004968651,0.003875276,-0.1105004,-0.018334612,0.045538347,-3.7380456e-08,0.02764387,-0.049922876,0.044897154,-0.006104252,-0.052864533,0.018386513,0.042280074,0.013310762,0.08640513,-0.033110023,-0.0021435767,0.13218051,0.021154312,0.0019943586,0.082789116,-0.018938048,-0.02100908,0.019213337,-0.010976735,0.03439952,-0.044437356,-0.02224056,-0.112835966,0.0095369285,-0.036740508,-0.06378995,-0.0063108406,0.055638246,0.00041376136,-0.02301699,0.017718304,0.048533577,0.06617549,-0.002637593,-0.06551158,0.03071345,0.012887913,-0.008887054,0.00222791,0.0120650185,0.014555788,-0.046169695,-0.017057884,0.005614621,-0.040297326,-0.00768234,0.006323432,0.019105306,0.04989784,0.030418692,-0.03608942,-0.023852954,0.01566012,-0.0029697006,-0.034731418,-0.06263724,-0.104825795,-0.10943401,0.01663615,-0.019830551,0.0099707125,0.05770963,0.20050736,-0.018616512 +1.1.1.271,Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.,384,1.0,-0.047619686,-6.552503e-05,-0.06479859,-0.017581064,-0.027318196,0.053008314,-0.043021124,0.04705898,0.07213338,0.022687538,-0.030196933,0.03598266,-0.06387433,0.12455109,0.027719013,-0.041383732,-0.030937832,0.040847182,0.03670908,-0.028155832,0.062005643,0.046931952,0.014855597,-0.07349913,0.058618937,-0.011809794,-0.011380991,0.016076326,0.02603246,-0.026272211,-0.073388435,-0.011726981,-0.033274874,-0.04529666,0.024545616,0.08579861,-0.027055377,0.016689554,0.01930655,0.0032886642,0.0013362591,-0.020775987,-0.079907835,-0.005699743,-0.028206764,-0.05346848,-0.008549887,0.053303987,0.054751463,0.0048516593,-0.065555714,0.0018810855,0.037281416,0.03525254,0.065486945,-0.022156935,0.054396763,-0.023539415,-0.042158213,-0.07848569,-0.035569325,-0.07031148,0.026929516,0.033167,0.050660595,-0.07170637,0.076382,-0.0026571974,-0.030395053,-0.04568221,-0.10972086,0.003359776,0.045329377,0.028869035,-0.020026376,0.07075053,-0.053238217,-0.083835766,0.038320754,0.054164194,0.06752798,0.042170852,-0.0025841603,0.031669866,0.073108256,0.11438658,-0.0028079522,0.013329023,-0.019413795,-0.0069648246,0.0032628977,-0.09371481,0.026013136,-0.026297284,-0.12633552,-0.039470505,0.024661068,0.01613597,-0.0240953,-0.045658417,-0.02339188,0.058085408,0.023474244,-0.057673275,-0.04719535,0.027039882,-0.015106269,0.09963223,-0.019625327,-0.015867146,-0.023142997,-0.011799025,0.010955291,-0.022061056,-0.07372266,0.073319614,0.0042001917,-0.028038748,-0.11361841,-0.049833085,-0.04041377,-0.011006082,0.011964553,0.01635166,0.033604868,-0.001644435,-0.08063,-1.0989898e-33,0.1159879,0.09016051,0.027974661,-0.018734548,0.057015214,-0.008937603,-0.07231327,0.061673082,0.010290062,-0.06442315,0.026596373,-0.091990225,0.040193707,-0.04289852,0.026198648,0.06902458,-0.044068605,-0.06421975,-0.07079101,0.022013584,0.07429171,0.028080251,0.012244329,0.042975735,-0.024361216,-0.036496352,-0.060185723,0.06517028,-0.0076766433,-0.0060069254,0.037464947,-0.043011636,-0.122322425,0.028032567,0.07640323,-0.022881528,-0.039527155,-0.03787671,-0.00033554214,0.06329345,-0.042133957,0.07979552,0.0126381535,-0.036261514,0.030693064,-0.14313205,-0.011464061,0.06562982,0.0083666155,0.054141942,0.043373764,0.0013809629,0.09147349,-0.06959887,-0.0042980067,0.033467423,-0.020818084,-0.08538891,-0.0031242059,0.07332663,-0.0008410935,-0.034197964,-0.04059659,0.065049686,-0.05314268,-0.0066575683,-0.087066464,-0.04423216,-0.006244768,0.1265396,-0.019239722,0.015691979,-0.010787497,0.029790957,-0.00825923,-0.049428947,0.011616115,0.010776527,0.08523443,0.0017821727,0.06057729,-0.08670814,-0.08020574,-0.009613723,-0.005284901,0.056236446,0.063176066,-0.044843093,-0.036093704,0.02385682,0.08095321,-0.037987042,0.026929673,-0.06659943,0.00059366546,-2.2533681e-33,0.06744593,0.0060937586,0.03439191,-0.12612398,-0.027247837,0.09500415,0.07727342,-0.081144065,0.0068380297,-0.097287305,-0.016369687,0.0718,0.057292514,0.014522239,0.016703546,-0.03374703,-0.040918242,-0.016057251,-0.002984988,-0.00050444173,0.0004451894,0.07559621,0.016797923,-0.039313905,0.12023087,-0.07612878,-0.08230126,0.07436011,-0.0061976938,0.048988845,-0.018511087,-0.014918672,-0.097803794,-0.08268381,0.033995785,0.024644798,-0.06068973,0.008646286,0.034076568,0.017348856,0.0058061103,-0.014839648,-0.08384252,0.04787962,0.02252616,0.07561246,-0.09672927,-0.040367875,0.027318407,-0.06291631,0.036720313,0.007021349,-0.067036204,-0.037431315,-0.008952012,0.030173635,-0.01137704,-0.0010868046,0.06708857,0.008042059,-0.014284821,-0.020736542,-0.039159857,-0.013614784,-0.011997539,-0.028752616,0.021743145,-0.023651073,0.055995427,-0.05958992,0.06703717,0.030799774,0.032076407,0.061125696,-0.013000053,-0.07845083,-0.10216757,-0.010279882,-0.03972288,-0.034419846,-0.03703661,0.045517392,-0.046939045,-0.019931586,0.03722883,0.0106718065,0.04696471,0.00048416664,-0.07074895,-0.010310833,-0.053804204,0.07712933,-0.009578417,0.030885877,-0.0137308175,-2.4506058e-08,0.07191404,-0.007290905,0.06305705,-0.050159708,-0.024060471,0.017846335,0.053025283,-0.041622173,0.0341062,0.04339128,-0.010234335,0.18725096,0.07650774,0.06970095,0.03763472,0.020930225,-0.05257799,-0.00798003,-0.049397375,-0.044950157,-0.032522142,0.019001672,-0.06735458,0.0806148,0.0024200622,-0.012942143,-0.007211243,-0.030206617,-0.034128617,-0.08052173,0.0326944,-0.03199463,0.09526943,0.002141741,-0.050634153,-0.0042332006,-0.045420375,0.051649764,-0.012418946,0.035886467,0.04620053,-0.062476516,-0.04507226,0.06671285,0.02205277,0.022271153,0.050372113,-0.035088718,-0.047145404,0.01357757,0.09197174,-0.0072484426,-0.01759136,-0.015199686,-0.036620058,-0.008415086,0.011857105,-0.07690036,-0.013950293,-0.07651672,0.04416554,0.0028764892,0.122584626,-0.07143021 +1.1.1.272,"This enzyme, characterized from the halophilic archaeon Haloferax mediterranei and the mold Aspergillus oryzae, catalyses a stereospecific reduction of 2-oxocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. The enzyme prefers substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use NADH with much lower efficiency. cf. EC 1.1.1.345, (D)-2-hydroxyacid dehydrogenase (NAD+).",384,0.99999994,-0.014350311,0.037671905,-0.047325198,-0.05276165,0.027484579,0.041830547,-0.14413883,0.051313125,0.038899656,-0.013924724,-0.018228704,-0.029409604,-0.06847394,0.01767518,-0.06929134,0.057579145,-0.009735248,0.038204,-0.0022312975,-0.027855486,0.053539217,0.06296958,0.019388115,0.012159481,0.04284343,0.037757356,0.05024111,-0.019944508,-0.04672784,-0.10324427,0.052109603,-0.017424064,0.034266345,-0.036928672,0.044483867,0.049277116,-0.023548365,-0.0076429965,0.041265603,0.04244572,-0.0021581373,-3.3162967e-05,-0.034816112,-0.03894861,-0.06508992,-0.055003554,-0.04827583,0.02469705,0.05543151,0.01867836,-0.041032296,-0.056744885,-0.03864218,-0.018729588,0.04068304,0.03402072,-0.0075173285,-0.00830964,-0.023798566,-0.037935488,0.060642824,0.005396309,0.014891851,0.043850977,0.0014883314,-0.04911393,0.044957835,-0.10026288,-0.0044274195,-0.09423187,-0.11090417,-0.038259596,0.011995821,0.017654456,0.02376554,0.006953998,-0.059257515,-0.109646685,0.087278776,-0.050315697,0.0843038,0.05860327,-0.029687528,0.045416135,0.033340774,0.01757843,0.030939363,0.024774821,0.04874277,0.009656281,0.00790269,-0.013555792,-0.0014360207,0.025508884,-0.07381294,0.0170021,0.07295128,0.0863287,-0.025794001,-0.011073647,0.037274178,0.05544854,-0.05091418,-0.11267397,-0.040686615,-0.018742511,-0.0024615617,0.106712796,-0.008573497,-0.037340697,0.025970057,-0.050736297,0.0032950887,0.0008719288,-0.05177888,0.12080685,0.053607274,-0.024737598,-0.089245334,-0.048240613,0.05136693,-0.021563517,0.038931023,0.015099575,-0.038370032,0.03154747,-0.118884526,2.2619283e-33,0.070880294,0.0291866,-0.037051715,0.027286442,0.024903739,-0.013199863,-0.10151309,0.04742591,-0.05979638,-0.01349652,-0.09082784,-0.0042437124,0.0002782158,0.03602844,0.024044605,-0.031279106,0.015720975,0.016352315,-0.033239417,0.020842588,0.0075557274,0.07088349,-0.019780388,0.03390977,0.08071258,0.022058794,-0.0025395425,-0.010734681,0.061265744,0.000403892,0.006615371,-0.1347432,-0.07314399,0.018598208,0.07402187,0.010807238,-0.025847796,-0.025201898,-0.022052439,0.013187434,-0.08596019,0.047855064,-0.054084122,-0.07631267,0.018005108,-0.07671993,0.026585028,0.05953357,-0.0042807087,0.0466804,0.04311263,0.012766201,0.051200394,-0.018239534,-0.053696763,0.019100076,-0.05236277,0.010642394,0.06723098,0.069022745,0.015263807,0.03938536,-0.009515012,0.033760108,-0.027120233,-0.06682764,-0.09240437,-0.0378953,0.008301464,0.044139266,-0.016448598,0.008208926,0.025964094,0.041024603,0.015267605,-0.07883164,-0.0025233107,-0.020337362,0.041919407,-0.033854138,0.017433314,0.04821493,0.020662965,-0.04380119,-0.018342054,0.07808422,-0.022821747,0.0026678173,-0.047724772,0.057231873,-0.063455656,-0.06692717,-0.01449122,-0.053489707,0.092605926,-4.2530418e-33,0.061564565,-0.06256254,-0.022453828,-0.10603637,-0.016725147,0.11669375,0.062941566,-0.042864293,0.011564317,-0.043519687,0.05888706,0.06764313,0.067191906,-0.04703333,0.045402005,-0.0238417,-0.019090854,0.02633603,-0.020758001,-0.012797024,0.060625404,0.11441326,0.007593764,0.010217858,0.013271603,-0.008935548,-0.052382108,0.043108694,0.07072856,0.081311174,-0.044367593,0.051078543,-0.002944241,-0.0053207935,-0.031937912,0.100456476,-0.07778612,0.0017766486,-0.054007843,0.10797129,-0.10528891,-0.021006417,-0.056553684,0.022829099,0.05576484,0.052844536,-0.06489515,0.0038866817,0.07122241,-0.10691921,0.03360536,0.022741444,-0.008870269,0.034417957,0.049637448,-0.0027285125,-0.0073155705,0.01178938,0.05233031,-0.059808843,-0.044916734,-0.039695818,0.039216626,-0.032108944,0.01427678,0.022566494,-0.01008497,-0.019358626,-0.011305087,-0.056053847,0.1040665,0.020840127,-0.013741202,0.06140137,-0.0073281284,-0.086965404,-0.074458934,0.006164055,-0.0059366026,0.019932095,-0.013757597,-0.0111406185,0.06373356,-0.03530378,0.01692503,-0.12114863,0.04544251,0.078552306,-0.10156712,0.072049305,-0.02229095,0.04493473,-0.07626053,0.05599257,0.033223845,-4.1636863e-08,0.02877543,-0.0571635,0.05526288,-0.058229417,-0.029748606,0.006049259,0.05917972,0.022618739,0.06525172,-0.094594434,-0.007679832,0.09542266,0.041019943,0.09654776,0.014786905,0.023396442,-0.028754141,0.051117133,-0.017225638,-0.0041191364,-0.053690013,0.002578912,-0.09884656,0.006594174,-0.033794668,-0.03433017,0.0429897,-0.014734669,0.012457325,-0.02373328,-0.016694548,0.08015938,0.029647572,-0.083835945,-0.05009182,0.027051948,-0.08118089,0.03360311,-0.043584622,0.051681887,0.018447142,-0.06603062,-0.03373589,0.026113996,0.035822786,-0.012893494,0.0464591,0.031721324,-0.050617587,0.030002994,0.07700876,-0.021910798,0.007630989,-0.054634668,-0.08530783,0.01356821,0.006640304,-0.11778118,-0.08064979,-0.10316423,0.022277297,-0.0034607456,0.16126683,-0.04189229 +1.1.1.273,Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae.,384,1.0,-0.015928902,-0.016030757,-0.12641734,-0.01463365,-0.017822541,0.06430174,-0.034799792,-0.009479859,0.043581203,0.027147809,0.07031173,-0.06408296,-0.017312631,0.046349578,-0.084052145,0.14844422,-0.035169907,0.048600826,-0.05090699,0.053715717,-0.013739227,0.017251043,0.035088163,0.044957384,0.02588857,0.00048850494,-0.078940205,0.06852835,-0.023312975,-0.07143523,0.007091441,0.07657095,0.008757283,-0.044258423,0.035485763,0.05816826,-0.07519543,0.049812384,0.056915443,0.013676486,0.002242354,-0.016532652,-0.020880608,0.04725659,-0.08484699,0.0044472804,0.016201807,0.029481178,-0.025527533,0.015205874,0.09232857,-0.021401562,-0.06280902,0.024096189,-0.033553235,-0.066022955,-0.038813844,0.1124331,0.009831129,0.06333273,0.030125828,-0.038185094,0.003037853,0.055517484,-0.045226958,-0.019435337,-0.028235078,-0.032867294,-0.0035525493,-0.07269358,0.050692953,-0.07649338,0.053006653,-0.0013390798,0.005108417,0.12459841,-0.041425876,0.008982539,-0.07152205,-0.075465225,0.045380525,0.025502924,-0.005834741,0.027536428,-0.027184691,0.013515048,0.019469017,0.053497907,-0.046034038,0.015273199,0.072625786,-0.06121692,-0.041484665,-0.04052958,0.0057342793,0.0514898,0.10145203,-0.008616533,0.041519526,-0.055114035,0.011117029,-0.031712383,-0.07190164,-0.016694173,0.016022943,-0.018616624,0.010850687,-0.038552396,-0.049155187,-0.04624595,-0.037797898,-0.010560893,-0.03450482,-0.0037290745,0.017169323,0.040166385,0.081869476,-0.06163219,-0.07454365,-0.03014782,-0.050951518,0.011043402,0.045075648,0.071864694,0.06635951,0.002884186,-0.045400728,3.5946665e-33,0.032533456,0.037356537,-0.032025073,0.012509131,0.11342315,-0.007064823,-0.05144844,0.0013383466,-0.06489862,-0.028020097,-0.1423451,0.036446035,0.0561349,0.00024158506,0.012535597,0.064110056,-0.075756274,-0.042686813,0.027995529,-0.07551162,-0.043049973,0.018359333,-0.07626128,-0.0026926654,-0.09592535,0.08439269,-0.00061128667,-0.020386333,0.0324507,-0.060851973,0.026641369,-0.012044049,-0.05840646,-0.008327548,-0.029630722,0.07741173,-0.047853936,-0.016968878,0.020600202,-0.024431037,0.08338601,0.104193926,-0.04339448,-0.0075305197,0.04099172,-0.053094156,-0.08382578,0.045828003,0.036485627,0.029111192,0.01588202,-0.012779313,0.034579236,-0.036566116,-0.07246757,0.03841147,-0.010361349,0.04757203,0.028840367,0.04245468,0.014059028,0.04251486,-0.022035334,-0.041611426,-0.006078346,-0.01596266,-0.060027145,-0.04556708,-0.0055401297,-0.003718806,-0.029971218,-0.05002526,0.0036761626,0.006778793,0.0014389693,0.048875384,-0.01131159,-0.010804022,-0.015106612,0.010178755,0.0533179,-0.048497863,0.024345333,0.009943712,-0.05552552,-0.012469089,-0.0532106,-0.05520729,-0.041023366,0.12902467,0.019602118,-0.020249894,-0.05655843,0.036979575,-0.0039798627,-5.4613563e-33,0.09443339,-0.05199007,0.08610282,-0.046338048,0.032044142,0.028845154,-0.06184117,-0.016837483,0.023155041,0.051109586,0.083585724,0.017395282,0.03811558,0.0418212,-0.025354834,-0.08665466,0.028586613,0.15603776,0.037563965,-0.03485991,-0.14706941,0.027746037,-0.06655887,-0.0295045,0.026050393,0.020315174,0.014553865,-0.023219256,-0.055058707,0.015027523,0.029053021,-0.039638054,-0.045823127,-0.023879645,0.05778905,0.02397309,-0.066780984,-0.031893313,0.0046210443,0.031713054,0.026475016,0.06828232,0.027772032,0.05145561,0.053770874,0.02546116,-0.05870135,0.07105393,-0.054108616,-0.039358415,0.06619261,-0.0057486403,-0.025675908,0.017728964,0.102265574,0.04118081,0.049968053,-0.062207866,-0.09198798,-0.05009755,-0.0057364292,-0.047366813,-0.021463245,-0.078300335,-0.017882464,0.11877861,0.014494034,0.03465334,-0.0062348936,0.007925732,0.11284063,-0.01331496,-0.08830843,0.050517872,-0.018112212,-0.021756556,-0.018814167,-0.09356273,0.032399964,-0.030302132,-0.031529024,0.0038388849,0.057908937,-0.019620309,0.01897572,-0.023186294,-0.03940784,0.06943621,0.013637415,0.030340401,0.064610764,-0.028062597,-0.033269677,0.024265176,0.12454555,-3.351046e-08,0.02928687,-0.019510536,0.067794345,-0.02367849,-0.04795404,-0.04149352,0.06524903,0.062454175,-0.024150886,-0.053296432,0.030815328,0.009059153,-0.024093417,0.030836988,0.053526446,0.00317716,0.040939867,0.031863146,-0.00861258,-0.0083306935,-0.13443613,-0.009095674,0.022975586,-0.025963392,-0.043947384,-0.041323896,0.030781435,-0.028253738,0.0816897,-0.10085694,0.16256638,0.0018506317,-0.020252237,-0.083075136,-0.060511764,0.016856823,-0.017374977,-0.028104343,0.011233905,0.020647915,0.015529197,-0.048254408,-0.030391973,0.01975932,-0.012660294,0.0040157526,-0.018283863,0.034817595,-0.03803667,-0.004634065,0.057594653,-0.00069529883,0.027291402,-0.10028455,-0.13114075,-0.07664646,-0.021086598,0.00928614,0.06226955,-0.108182326,-0.011336564,0.023226323,0.119254604,-0.023830887 +1.1.1.274,"The enzyme is involved in the catabolism of 2,5-didehydrogluconate. cf. EC 1.1.1.346, 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).",384,1.0,-0.012912018,-0.056982245,-0.08341729,-0.023696909,-0.054874863,-0.027844967,-0.05084065,0.03267951,-0.01668848,-0.03535778,-0.008330544,-0.035688996,-0.02092391,-0.001032133,-0.047790352,0.030843172,-0.08335622,-0.02271347,-0.03404616,-0.06716574,0.070134714,0.009672306,0.028357128,-0.021413099,0.12414377,0.037248977,-0.010780019,-0.0049898997,-0.051295396,-0.09419716,0.0010616642,-0.016906334,-0.00017439813,0.0033181077,0.038587604,0.0991462,-0.09624202,0.01406714,0.004011732,0.04055695,0.028573168,-0.08728536,-0.0059186737,0.0026875501,-0.08099721,0.021503389,-0.04053031,0.038373467,-0.008001417,0.030807601,-0.06877926,-0.06944479,-0.0013629935,-0.037661955,0.03690663,-0.035518423,0.026181515,0.059667617,-0.058922697,-0.0017561229,0.045901943,0.0030634499,-0.04232233,-0.004521183,-0.007913507,-0.049389992,0.081984855,-0.12473279,-0.021505378,-0.001708831,-0.029244328,-0.055320915,0.027146116,-0.024479933,-0.07117885,-0.009421701,0.027352193,0.03297477,0.06367385,-0.022033138,0.085784085,0.030294584,0.018502481,0.03134517,0.0056217425,0.014291032,0.008134202,-0.015895596,0.04409721,-0.0074194036,0.03593943,-0.04058803,-0.057539847,-0.04021665,-0.067003936,0.044952363,0.009086244,0.04104184,0.060252685,-0.003067084,-0.0018972359,-0.033577193,0.0048723957,-0.0374293,-0.11067851,-0.04899233,-0.034633934,0.034811992,-0.04344734,-0.021183945,0.04744236,0.017218174,0.04858847,0.069721706,0.01994687,0.12976308,0.08898501,-0.06101252,-0.08373286,-0.039518803,-0.00738307,-0.042981327,0.0647521,0.082860716,-0.08654771,-0.030049032,-0.09338414,-4.110434e-34,0.07664103,-0.013295374,-0.028064998,0.05383221,0.011334636,0.015708156,-0.111371614,0.05766694,-0.07965629,0.010106878,-0.035596766,-0.05385345,0.05117162,0.036948677,-0.051628534,-0.024777351,0.027045425,0.0031038122,0.0028390475,-0.032106552,0.02879132,0.09427718,-0.011714806,0.05358585,-0.023393743,0.091887735,-0.025571443,-0.054825205,0.03701807,0.014073805,-0.007694218,-0.17458957,-0.06872378,0.03972267,-0.010074713,0.022448294,-0.09153761,0.021458665,0.023601335,0.029336011,0.0944121,-0.0021444065,0.001373718,0.0045892475,0.07805424,-0.0025490099,0.011938058,0.07484274,0.07258582,0.08709601,0.04314813,-0.03614151,0.108445354,-0.027315073,-0.08723276,0.05722476,-0.041009057,-0.01401167,0.00057455554,0.08121403,0.003993614,0.06824015,-0.026450554,-0.006254445,-0.038676567,0.0020744193,-0.022789892,-0.037294783,0.034565292,0.078484565,-0.012550178,-0.01397891,0.06377223,0.06431751,0.04247814,-0.02415494,0.02639231,0.027758246,0.013759834,0.015237691,0.0053940574,0.02535574,-0.0026234738,0.00305983,-0.095183,0.050869033,0.017673174,-0.109542206,-0.09112523,0.09934879,-0.031603742,-0.05649742,-0.050685637,-0.037680447,0.1328514,-1.3459456e-33,0.11253437,-0.08353341,0.052264158,-0.08215874,-0.0068393173,0.053512212,0.060445312,-0.010565772,-0.01825824,0.020164095,0.08210618,0.02478546,0.017434869,0.010936315,0.06168367,-0.041107688,-0.016865436,0.06873477,0.0076635648,0.017267374,-0.002122386,0.060609385,-0.017975243,0.011244242,0.06601285,0.031704437,0.043635447,-0.0021250774,0.045416765,0.026087474,-0.038073346,-0.024070844,0.013397989,0.00054560346,-0.049832035,0.044383198,-0.089765035,0.035170514,-0.07990449,-0.0010665321,-0.04188736,0.069413334,0.012689346,0.036725353,-0.006406163,0.049423672,-0.07305278,0.034541115,-0.02730743,-0.10680299,0.05004156,0.025672123,-0.024277117,0.0270666,0.014750263,0.05925829,0.033616498,-0.0051507065,-0.053407073,0.003278096,-0.051489785,-0.056153398,0.038534455,-0.020385744,0.06491502,0.011063282,-0.0012908258,0.012892817,-0.031004924,0.010228265,0.053274535,-0.010401402,-0.021390708,0.022534797,-0.052789792,-0.059403613,-0.11685235,-0.016614562,0.011416824,-0.074326016,0.01234291,0.0073866495,-0.030106105,-0.021662718,0.030126167,-0.109299876,0.071029246,0.13946451,0.012828262,0.055779047,-0.0015738832,0.03637762,-0.037320603,0.048745986,0.10611444,-3.666217e-08,0.05199066,-0.025648782,0.0066834413,-0.034390423,0.05758922,0.029639125,0.0124041205,0.0213452,0.004111751,-0.013915382,-0.036670752,0.05674133,0.004792393,-0.0012746409,0.026913218,0.0425787,-0.03735657,-0.036382794,-0.022523742,0.009040489,-0.03601785,-0.017108206,-0.14570081,-0.03566184,0.0083492985,-0.025436137,0.010884177,0.054454323,-0.02330672,-0.032519266,0.061476383,0.014170667,-0.01265652,-0.06197159,-0.07937863,0.0011763531,-0.036768425,-0.059596214,-0.021732591,0.01992845,-0.027401777,0.0060537583,0.033071797,0.059907537,-0.08150873,0.016695984,-0.03378598,-0.06598907,0.026734961,0.0782281,0.0016803062,0.03759719,0.00384564,-0.03840744,-0.11987636,0.01602654,-0.010347391,-0.033152852,-0.049535252,-0.009193366,0.04718693,0.060344435,0.19902919,-0.063675866 +1.1.1.343,"Highly specific for NAD+. The enzyme catalyses both the oxidation and decarboxylation of 6-phospho-D-gluconate. In the bacterium Methylobacillus flagellatus the enzyme participates in a formaldehyde oxidation pathway [4]. cf. EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating).",384,0.99999994,-0.050846953,0.014787244,-0.07456021,-0.03518395,0.030580837,0.03241562,-0.065443106,-0.011612735,0.025848633,0.09113838,-0.029118739,0.018792758,-0.1251601,0.02897784,-0.047949735,0.026168006,-0.08071559,0.034608115,0.008423051,0.013437441,0.049173202,0.007940529,-0.004799267,-0.056993045,0.104576774,0.044666544,0.016078306,0.0065861717,-0.040533442,-0.04078287,-0.021602599,0.03424413,0.015916275,-0.024833096,0.030306298,0.07136405,-0.018978288,-0.048877195,0.061309382,0.007952857,-0.043398503,0.036601696,-0.022164883,0.004575699,-0.10327223,-0.023022052,0.037714057,0.080036044,0.019980127,-0.03617043,0.0052986983,0.005026742,-0.028229889,0.020334184,0.0071348394,0.025044234,0.029537834,-0.015662864,-0.05824113,-0.074228145,-0.034871805,-0.0460457,-0.007956223,0.0563311,0.05138183,-0.066505484,0.055032086,-0.019756451,-0.009743028,-0.07674865,-0.110892676,-0.06261946,0.020757213,0.012168893,-0.03373059,0.035765637,-0.04764322,-0.04488406,0.08465109,-0.039623965,0.06590192,0.029555816,0.04582852,0.054795403,0.036675572,-0.020812402,-0.046001572,0.048552435,0.034056515,0.00081490196,0.009663654,-0.03886182,-0.018902535,0.0030211401,-0.09743833,0.010457009,0.019532474,0.08656904,0.028867533,-0.085206635,0.023765275,0.08549028,-0.055074926,-0.03262272,0.042250484,0.0068849423,-0.007847022,0.13350455,-0.053832132,0.011277048,-0.017905142,0.030701099,0.038787857,-0.047643516,-0.013031696,0.09927656,0.06444058,-0.022768062,-0.122301124,-0.069416165,0.037361402,-0.048583426,0.02199805,-0.038038842,-0.035197396,0.04100236,-0.116706915,1.8244302e-33,0.08246359,0.02254745,-0.028294234,-0.031574618,0.07826236,0.021347214,-0.074043944,0.02180759,-0.048169997,0.012383988,-0.088009104,-0.031217692,0.008856785,0.024237337,-0.0017903037,0.06793173,-0.071979925,-0.064715445,-0.0038408355,0.0329018,0.04170882,0.04624403,-0.01445961,0.037863407,0.07443411,0.089969516,-0.0069773505,0.05408536,-0.04017684,-0.012316578,0.067538284,-0.13579893,-0.12105672,-0.039505586,0.0626798,0.0016553086,-0.07613962,-0.008037036,-0.024399452,0.04834234,-0.03696652,0.015357373,-0.025202926,-0.03648523,0.013058292,-0.04848622,-0.020919636,0.063618705,0.047570467,0.0529823,0.03134582,-0.031952716,0.07156125,-0.024803849,-0.042411167,0.06515453,0.009762089,-0.03131673,0.038349267,0.10656781,0.022193627,0.019608803,-0.042259824,0.036364798,-0.011745638,-0.013498007,-0.061684754,0.00048353008,0.037329603,0.08278694,-0.02150632,0.0004452209,0.066289134,0.033685792,-0.0072972164,-0.01257056,0.007096182,-0.031816985,0.010055697,-0.023352614,0.0407869,0.022433158,-0.010306964,-0.019838803,-0.011693762,0.013969871,-0.03629403,-0.02396518,-0.03181638,0.019736582,0.01393529,-0.032959115,-0.026121095,-0.030457268,0.008684812,-3.417686e-33,0.11035177,-0.066240005,0.018993637,-0.122423865,-0.022053735,0.07965968,0.021689583,-0.058367666,0.01605825,-0.06479069,0.025531517,0.054226555,0.016615849,0.030527374,0.02998745,-0.041161913,-0.041597795,0.07241332,-0.009270658,-0.06380406,0.03675162,0.12012771,0.016634535,-0.043978494,0.036289267,-0.085247405,-0.053245395,0.06422366,0.041804817,0.035536565,-0.003758953,0.03811399,-0.022348097,-0.0089057,0.04156613,0.029272156,-0.08727471,0.005362237,0.01196191,0.057798278,0.0012590481,-0.023418542,-0.041464575,0.056129146,0.07075747,0.0073916824,-0.2011706,-0.042104922,0.029671134,-0.033459667,0.0370194,0.03234655,-0.040473647,0.06299925,0.091445826,0.039991,-0.0068907235,0.0072185486,0.06613612,0.037289802,-0.046942014,-0.07837211,0.043232687,-0.022592695,0.047124885,0.015028668,0.00087411853,0.025865829,0.04859684,-0.0145173855,0.06330429,0.018512703,-0.06748392,0.057431377,-0.043261826,-0.07301251,-0.10659582,0.046367317,0.03895289,0.03667798,-0.02505915,-0.028166506,0.011784029,-0.013630315,0.033810627,-0.051465183,0.015765015,0.09239239,-0.078118116,0.036026563,-0.0004060928,-0.000618376,-0.0004477749,0.018241834,-0.055116754,-3.8404483e-08,-0.028021235,-0.054645605,0.06658687,-0.038606305,0.044663638,0.09255108,0.04593453,-0.01579473,0.009003613,-0.01806023,0.049771465,0.09164568,0.021642232,0.025965646,0.022234598,0.04954313,-0.09557246,-0.023971582,-0.037094414,0.009118219,-0.014319189,0.05442771,-0.12853457,0.1068951,0.023006398,0.0033753514,0.052141912,-0.025646988,0.0051008267,0.008222197,-0.022415709,0.08393505,0.043045215,-0.06079051,-0.10102188,0.00892071,-0.007994265,-0.03508029,-0.019186573,0.012209783,-0.016727747,-0.088954516,-0.05501953,-0.0024183819,0.026415914,0.039555617,0.016892442,0.0040801335,-0.11361473,0.03247679,0.12218982,-0.005843139,-0.0048207305,-0.044603266,-0.11685054,0.02478766,-0.042637683,-0.04669746,0.01241263,-0.012639467,0.05430332,-0.028979927,0.13810013,-0.069618136 +1.1.1.275,NADP+ cannot replace NAD+. Forms part of the monoterpenoid biosynthesis pathway in Carum carvi (caraway) seeds.,384,1.0000001,-0.053828657,0.020016687,-0.042290714,-0.013340624,-0.035073634,0.080630586,-0.127675,-0.023045877,0.052345663,0.020783344,0.041900773,-0.0015316226,-0.037445594,-0.04288008,-0.037598062,-0.039657407,-0.04091684,0.024013251,0.03510876,0.034274865,0.055574685,0.03370757,0.013460087,-0.027322501,0.082783714,0.04174995,-0.022143269,0.012901826,0.027178558,-0.03392785,-0.081630886,0.09332541,-0.014561408,-0.091086105,-0.023240529,0.018314246,-0.025187375,-0.0037317323,0.044929974,-0.031583525,0.06284315,0.037868336,-0.06104242,0.0063872635,-0.0063411472,-0.066023424,-0.012321748,0.03250053,0.01058968,-0.025651494,-0.03356573,-0.0015330043,0.0003410391,-0.06116503,0.021695834,0.008617327,0.049865007,-0.013651841,-0.003701793,-0.05316979,0.036062002,-0.07345027,-0.02867588,0.010430713,-0.020134736,-0.052280027,0.01945372,0.032088272,-0.010336938,-0.0026893825,-0.1043277,-0.009182269,-0.0032786697,0.0030563194,-0.014597862,0.15701091,-0.04602569,-0.03564322,0.04744415,0.014528968,0.033451375,0.034195777,-0.028270809,0.057099473,0.07955893,0.037200063,0.037095476,-0.014898084,0.006346841,0.012315871,-0.007884689,-0.059280492,0.036806796,0.06261996,-0.16191489,0.014396983,0.08987786,-0.066859335,-0.0406011,-0.09932997,0.033021722,0.07025019,0.0034935954,-0.053294282,-0.05042919,0.051250927,-0.08766773,0.06583712,-0.039783172,-0.035298955,0.0028704717,-0.016451495,-0.0008440825,-0.08586063,-0.068897516,0.079741284,-0.06310173,-0.040620994,-0.05450599,-0.0052247425,-0.04360849,-0.036185592,-0.027902085,0.0137777915,-0.015853584,-0.058141507,-0.054096177,4.434656e-34,0.054854434,0.03673404,0.0035654614,0.014603786,0.08210469,0.0078120297,-0.070799455,-0.0034382755,-0.031039137,-0.0702637,-0.0517912,-0.098909006,-0.011597844,-0.043086126,-0.001962216,0.054518998,-0.059799377,-0.049140543,-0.016658148,-0.008637997,-0.03586798,0.067721166,-0.040203456,-0.016986035,0.038637053,0.058434952,-0.007682938,-0.017362282,0.023100303,-0.0068485714,0.068558425,-0.056314792,-0.105610706,0.05291626,0.088648714,0.0072267586,0.038115688,-0.07295603,-0.06406603,0.027950732,-0.08173942,0.08374614,0.022246262,-0.02310005,0.018366164,-0.08721817,0.032999292,0.05340417,0.059195507,0.067880996,0.021519039,0.015131992,0.11216887,-0.017523563,-0.07731079,0.09710713,-0.02489359,0.017321918,-0.042635724,0.044969905,0.03306501,0.011299913,-0.0043480727,0.06288607,-0.04116118,0.10690303,-0.13968071,-0.060956202,0.06515206,0.09294589,0.03995789,0.0148781575,0.016466243,0.014374513,0.054538134,0.0065927166,0.028620562,0.056588143,0.0037834402,0.029368615,-0.037904907,-0.0038006506,-0.04954144,-0.018292515,0.0027137883,0.04252482,0.014315384,0.014445219,0.06558903,0.0858659,0.11096059,0.033090938,0.009236694,-0.023740372,-0.02532706,-2.452713e-33,0.044137157,-0.03588541,0.08676381,-0.05329199,-0.021719167,0.11337071,-0.01740001,-0.11027464,-0.00362098,-0.057913795,0.007201607,0.10836297,0.06531117,0.012046099,-0.04192739,-0.04345779,0.025590857,0.078861326,-0.07768984,-0.02765372,0.00263441,0.084616505,-0.011580498,0.0016408747,0.021792196,-0.064974025,-0.04006708,0.027382936,-0.002469858,0.004877298,0.08707268,0.004611467,-0.11760636,0.015853565,0.03580084,0.05796547,-0.02019446,0.055105187,-0.022381773,0.0995784,-0.084912755,-0.021043397,-0.05196316,0.0024349326,0.1305802,-0.03913992,-0.07578572,-0.012932049,0.0197077,-0.018485788,0.063480996,0.05858824,-0.041587118,0.030901322,0.06858577,0.009222248,0.011633599,0.009309802,0.106990084,-0.008336611,-0.01153779,-0.04854412,0.004461935,-0.045195676,0.05016091,-0.014932924,0.029680092,0.006309622,0.027324656,-0.05810836,0.07149577,0.1015901,0.033927593,0.02563187,0.04559314,-0.012486478,-0.07519012,-0.05563778,-0.039431747,-0.023124611,-0.0020722465,8.52144e-05,0.027475232,-0.045408756,-0.06638264,0.005016492,0.025415804,0.044856712,-0.010033771,0.016556082,-0.014636579,0.044061836,-0.037285917,0.04190662,0.03615252,-2.4210165e-08,0.036171924,0.042808488,-0.023506569,-0.05035682,-0.011087227,-0.012772833,-0.035601377,-0.05980404,0.059374783,-0.018217817,0.012127066,0.11177923,0.027618697,0.024880104,-0.0067085507,-0.042934768,0.043414377,-0.010797022,-0.03553234,0.009542305,-0.09171724,0.01314533,-0.10008964,0.04843494,0.041942872,-0.097108275,-0.01147132,-0.043882184,0.076816656,-0.04453083,0.049345564,0.014756126,0.039574143,-0.041591026,-0.09142216,0.016842876,-0.0039336444,0.06799178,9.057476e-06,0.069782965,-0.00599365,-0.11862731,-0.05439767,0.01706657,-0.054985907,0.052437045,0.052373152,-0.028360022,-0.11530394,0.003526018,0.023983171,0.017584918,0.037965342,-0.08123442,-0.05135924,-0.0042596,0.034881007,0.013768558,-0.03856248,-0.028297413,-0.05933375,0.01737468,0.085983075,-0.011045154 +1.1.1.276,"NAD+ cannot replace NADP+ [cf. EC 1.1.1.387, serine 3-dehydrogenase (NAD+)].",384,0.99999994,-0.061595615,0.004365123,-0.021203205,-0.06551995,0.05053153,0.05120785,-0.097808495,0.011074037,-0.0027092765,0.014681276,0.0002994792,-0.016102228,-0.098598264,0.01902197,-0.0143319545,-0.025510687,-0.04656856,0.015033381,0.047641132,0.0052643847,-0.009561647,0.041426826,0.03119853,-0.016779754,0.10325253,0.061746247,-0.02148321,0.034264825,-0.048044562,-0.032076534,-0.015893394,0.033482756,-0.010401046,-0.07555857,0.011964973,0.03634679,-0.08413843,-0.028258413,-0.022258313,0.0128375385,0.009601039,0.02017553,-0.10810056,0.013973602,-0.047216885,-0.061280984,-0.0057011233,0.025548127,0.08007542,0.011927209,-0.04960697,0.019268619,0.01618089,-0.02499182,0.038329314,-0.055718567,-0.006717681,-0.005896019,-0.04197863,-0.12017959,-0.016639728,-0.058855977,0.012061342,-0.008391358,0.10052585,-0.029868823,0.09633643,-0.03934771,-0.047062814,0.04568839,-0.13251917,-0.009521737,0.0046662604,0.070831686,-0.026956752,0.0963155,-0.085500196,-0.026049824,0.114859246,-3.366051e-05,0.0386454,0.0013534386,-0.069142126,0.0509973,0.08004633,-0.0105828615,-0.026995862,-0.0056484113,-0.0050112954,-0.003684085,-0.009096495,-0.0248654,-0.0039745523,0.09235678,-0.10731079,0.04204607,-0.010656554,0.080466256,-0.038289946,-0.051162273,-0.014481757,0.13545276,-0.03304164,-0.005593331,-0.043410644,0.00195283,-0.013969756,0.124481775,-0.10274238,-0.03049124,0.025559902,-0.0424803,0.042292133,-0.037187237,-0.027301399,0.11864526,0.008409146,-0.03142242,-0.062784396,-0.032990374,0.041639384,-0.01142873,0.022192422,0.03387075,-0.033024587,0.01779058,-0.07382833,-7.373328e-34,0.081057176,0.01936868,0.0038856384,0.025533624,0.05573137,0.053084265,-0.06465461,0.06480699,-0.05239127,-0.017588908,-0.03104283,-0.10588272,0.0420857,-0.06962933,-0.0030623735,-0.0051243054,0.0029264386,-0.09007814,0.011347902,0.011734975,0.046539158,0.05752841,3.5892149e-06,0.0035639703,0.01205355,0.07114803,-0.033549163,0.06027363,0.046811353,0.013898254,0.060875043,-0.09475876,-0.097748846,0.020575581,0.0136734685,-0.018476244,-0.019780517,-0.057358254,-0.009889182,0.041088097,-0.103087954,0.077328674,0.01953372,-0.028885089,0.024979418,-0.065579176,0.030920453,0.10004812,0.00029487684,0.028339608,0.0047594123,-0.00776579,0.0613869,-0.090946585,-0.07364684,0.043412898,-0.028470343,0.089973584,-0.039084334,0.091891244,0.037961524,0.04842565,-0.0016980849,0.07733429,-0.005192719,0.020167174,-0.10585933,-0.014020114,0.04008123,0.060856022,0.018684857,0.032442667,0.08941275,0.051414084,0.030435272,-0.058417883,0.010642235,0.033186525,-0.020158745,0.013676982,-0.03538678,0.0051960098,-0.060582437,0.028703624,-0.0030546742,0.048702337,0.018359972,0.01100547,0.011776414,0.08229343,0.08072325,-0.020691939,0.030311065,-0.04906876,0.023187956,-1.3040146e-33,0.028730948,-0.015151909,0.020369962,-0.103095055,-0.03834703,0.12166181,0.037126776,-0.0765902,-0.030717736,-0.070337415,0.053019684,0.025240576,0.028287532,-0.07412813,-0.040956713,-0.028395584,-0.11431381,0.00042759968,-0.0149067035,0.011933428,0.06457873,0.15820408,0.0332148,0.02017294,0.03167712,-0.014745713,-0.00660717,0.08497417,0.02753802,0.03046475,-0.0030993898,0.056642566,-0.102194875,0.032091618,0.011547852,0.046373405,-0.025756864,-0.014796282,0.0040463763,0.032312095,-0.02412886,-0.009736729,-0.04494261,0.0044014594,0.10315982,0.034746524,-0.07089477,-0.044470813,0.044919662,-0.07724382,0.008200822,0.035286527,-0.07513249,-0.009586869,0.07022071,0.043270025,0.02156153,0.012571009,0.088392265,-0.00012004137,-0.03138039,0.003384631,0.03183358,-0.021142993,0.0819842,0.0032780934,-0.02882873,0.03318522,0.0821024,-0.05205305,0.02097164,0.019068187,0.003251317,0.014649984,0.04582728,-0.03853263,-0.12320042,0.097984806,-0.030284014,-0.029477304,0.013912997,-0.014604155,-0.020627199,-0.04056989,0.038117867,0.0033318729,0.028278984,0.06689428,-0.082379006,-0.0074235653,-0.0020501965,0.037997816,-0.07696432,0.062857606,-0.031681783,-2.423437e-08,0.048971847,-0.03789717,-0.0007755616,-0.062827066,0.052578885,0.004509075,-0.027868064,-0.044993874,0.025671229,0.003257347,-0.014796598,0.09950583,0.068383925,0.042674042,0.001810972,-0.064529866,-0.061422102,0.0040893666,-0.028182292,-0.058806583,-0.09312027,0.006529374,-0.10565854,0.03098502,0.049862582,-0.02855716,-0.008340037,-0.064054064,0.06543147,-0.051158313,0.019042276,-0.0014327216,0.066131316,-0.023797961,-0.03781698,-0.017462948,-0.019679355,0.02448203,-0.042742234,0.055286635,-0.0513379,-0.05645418,-0.07089162,0.037726358,0.0557372,0.03108154,0.06072259,-0.007481555,-0.109668046,-0.019997986,0.076489344,-0.010488426,0.0528568,-0.059511933,-0.021776188,0.0065171663,-0.03591273,-0.04541878,-0.004635463,-0.01731113,0.029493563,-0.08570813,0.0345633,-0.017050479 +1.1.1.279,"Also acts on ethyl (R)-3-oxobutanoate and some other (R)-3-hydroxy acid esters. The (R)- symbol is allotted on the assumption that no substituents change the order of priority from O-3 > C-2 > C-4. A subunit of yeast fatty acid synthase EC 2.3.1.86, fatty-acyl-CoA synthase system. cf. EC 1.1.1.280, (S)-3-hydroxyacid ester dehydrogenase.",384,0.99999994,-0.052184235,-0.08001876,-0.07591428,-0.0138567425,0.079636164,0.0637101,-0.09783304,0.010438302,0.02549302,-0.05465224,0.059326984,-0.08138306,-0.068608135,-0.04435652,0.0062339455,-0.01948018,-0.03608054,0.02082085,-0.03198538,-0.08067016,0.07165989,0.03325652,0.027022755,0.01896131,0.034739655,-0.009613973,0.050022833,0.004210842,0.005918245,-0.117748275,0.040143643,-0.08890854,0.11618472,-0.05269691,-0.012243694,0.018092848,0.018057663,-0.09514865,0.10265164,0.08942069,0.020353952,-0.042385694,-0.004969794,0.01806653,-0.020913605,0.00805318,-0.031040525,0.027673315,-0.00712855,-0.05538868,-0.021372832,-0.0708699,-0.06902041,0.032983527,-0.0011193185,-0.005687137,-0.025563344,-0.04191891,-0.06921285,0.00021739886,0.0010499206,-0.0028161968,0.046139207,0.064117014,0.01583119,-0.07749343,0.052486848,-0.031813443,0.01420551,0.022289911,-0.07899222,-0.09401212,-0.061090972,0.0114413425,-0.0058899443,0.07210499,0.034245435,-0.03866839,-0.002874741,-0.046079367,0.021452447,0.017633557,-0.021887666,0.048775245,0.032034017,-0.06427058,-0.014988851,-0.056799717,0.026236324,0.107546255,0.02565489,-0.02739061,-0.0018809119,0.064553775,-0.07035291,0.08962403,0.064510666,0.0639896,0.01698288,-0.031297486,-0.0471547,0.08576564,-0.020671451,-0.024179606,-0.04876507,-0.017059071,-0.04212551,0.052665893,-0.007988058,0.027716069,-0.0008748951,-0.11009461,-0.009175648,0.008936376,-0.06536036,0.02376403,0.040812925,-0.075706236,-0.036792744,-0.061869007,-0.052450757,-0.012381669,0.027603425,0.010211851,-0.046002746,0.0008811592,-0.10362339,1.0448102e-33,0.054602288,0.015808731,-0.0708169,-0.0076412596,0.014089818,0.0019603765,-0.0851615,0.0340467,-0.04135638,-0.0041138674,-0.02344014,-0.0064107743,0.03985721,0.05867333,-0.032598566,-0.03894863,0.071393274,0.06105896,-0.01584977,-0.03700465,-0.025260143,0.030521827,-0.050284926,-0.04985257,0.0020544124,0.056163542,0.009563389,-0.033606566,0.044106606,-0.015220457,-0.0022813145,-0.058394354,-0.051864572,0.030699112,0.07427557,-0.04050032,0.0025210774,-0.021351784,-0.0045459983,0.06963704,0.047294263,0.021200337,-0.009900393,-0.035551004,0.053155184,0.048342925,-0.016167054,0.08114803,0.10624715,0.078618534,0.007044275,0.012627192,0.18039949,0.0233142,0.019235592,0.012626337,-0.11984298,0.057193387,0.014993457,-0.042114478,-0.054734513,0.14400077,-0.012001611,0.028205499,-0.03374193,0.0027741962,-0.10851723,-0.1028636,0.034400243,0.07914294,0.00026629126,-0.03208153,0.07066725,0.045082457,0.0706813,0.0034724944,-0.12496655,-0.004264422,0.012610148,-0.012953451,-0.036506888,0.031461135,0.019766929,-0.011426284,-0.003544872,-0.0092593515,-0.014312864,0.022685064,0.018101113,0.023981117,0.043132972,-0.0818009,0.0024785865,0.04871993,0.036492124,-2.3668384e-33,0.11258484,-0.06334747,0.026242906,-0.1037229,-0.045908824,0.01784303,-0.031932443,-0.031276774,0.016676806,0.02129482,0.08628963,-0.020451875,-0.0035235293,-0.07783556,0.06908034,-0.038883816,-0.021268554,0.038407337,-0.08138393,-0.005432518,0.038086727,-0.009769658,-0.021742625,0.13261291,0.021838797,0.048223354,0.05249908,0.07498723,0.026682202,-0.016229648,-0.03438475,-0.008002028,-0.0038059372,0.016643925,-0.051920183,0.06421919,-0.035408366,0.060195368,-0.052826837,0.07562864,0.027997375,0.031614285,0.02800252,0.04757246,0.07138622,-0.0015489449,-0.049493544,-0.0002436476,0.0064208778,-0.06941431,0.010542078,-0.046544187,0.027567778,0.035676513,0.0741331,0.0988813,-0.012047231,0.039630417,0.046388555,-0.08108425,-0.01389041,-0.07290664,0.032668903,-0.036838006,-0.013689673,0.037248664,-0.033161096,-0.030517288,0.06548531,0.018363543,0.05952942,0.007493594,0.002422531,-0.016209407,-0.019096658,-0.11014329,-0.041349415,-0.084569104,-0.0518286,-0.04224354,-0.00544564,-0.031520836,0.024578128,-0.014188592,-0.064892225,-0.054357275,-0.008630394,0.030612946,-0.04316353,0.03800793,0.016150517,0.0313364,-0.057130776,0.12779579,0.028994517,-4.2170708e-08,0.040208098,-0.047325764,0.092640996,0.0008364944,0.037268978,0.039267942,0.04312906,-0.042572953,0.044203054,0.0178915,0.007885614,0.076890156,0.051447485,0.019975804,0.07801698,-0.06503083,-0.024550805,0.03945922,-0.020721773,-0.011557255,-0.06025088,-0.016151696,-0.03212468,0.02270704,0.048179034,-0.04945631,0.030617282,0.030815098,0.013215504,0.013541754,0.023417655,0.04756523,0.07433446,0.036512822,-0.0306241,-0.042918585,0.007798725,-0.053653438,-0.10246161,0.051517107,0.025643906,-0.028822226,-0.052467626,0.04908327,0.058106676,-0.03256156,-0.021808319,0.029966611,-0.028509978,-0.068165794,0.02659502,0.012598461,-0.06230451,0.009969598,-0.084566526,-0.06437132,-0.095111184,-0.05438361,-0.048802298,-0.00087381864,0.0383045,-0.007361919,0.16828291,-0.026441168 +1.1.1.280,Also acts on 4-oxo- and 5-oxo-fatty acids and their esters. cf. EC 1.1.1.279 (R)-3-hydroxyacid-ester dehydrogenase.,384,1.0,-0.053639542,-0.08076563,-0.052457955,-0.0050347312,0.0884429,0.031345405,-0.09244001,-0.03521557,0.024247522,-0.05007897,0.048588447,-0.054059368,-0.076465845,-0.0041332077,0.03153433,0.04077907,-0.054920893,0.027749963,-0.055840906,-0.08884676,0.08679488,0.010699831,0.0037835448,0.015953867,-0.025225107,-0.02600755,0.052311007,0.031016445,-0.07798787,-0.06832994,0.05809754,-0.05667117,0.07803789,-0.031937696,-0.04280446,0.06036869,-0.049687274,-0.08180114,0.09747383,0.09614546,0.0774822,-0.07217882,0.01600069,-0.025640791,-0.006863693,-0.06527732,-0.042756606,0.040315863,0.04564817,0.012234862,-0.027695742,-0.042194206,-0.06421609,-0.0031334434,0.0087778,-0.030065529,-0.0684951,-0.011150875,-0.049949564,0.04124656,0.005854049,-0.019385349,0.048530415,0.08510634,-0.028734513,-0.019133158,0.042964265,-0.097646125,-0.024547212,-0.03804026,-0.06962225,-0.11948689,0.045669753,-0.020695927,-0.07470557,0.04736049,-0.04483974,-0.07082787,0.021217244,-0.09279372,0.0058535617,-0.015407077,-0.005314895,0.0786033,-0.0012837247,-0.017607838,-0.027946584,-0.11368973,-0.0012036087,0.10913086,0.04316432,-0.052542906,-0.032615263,0.04651557,-0.03206875,0.03362313,0.06184189,0.027028807,0.013843848,-0.05272065,-0.04667232,0.03851059,-0.073970854,-0.03596043,-0.08538886,0.013108944,-0.017279176,0.057370737,-0.06444454,0.012505769,-0.020916883,-0.0477578,0.030322118,0.047137048,-0.04607538,0.06154974,0.02404128,-0.08620745,-0.07628923,-0.0668045,-0.02199123,-0.043278474,0.0936439,0.014774468,-0.039114047,0.007449943,-0.07494915,-2.2943442e-33,0.03224332,-0.04593724,-0.0045206295,0.03804575,0.022500359,-0.017489081,-0.08378079,0.037841123,0.006517236,-0.010686212,-0.015854528,0.022938013,0.11972567,0.01391982,-0.035926897,-0.016740058,0.033869453,0.042524233,0.020250712,0.03434554,-0.012239633,0.08446284,-0.035031807,-0.05569876,-0.03535646,0.08420208,-0.04732532,-0.04749613,0.05473907,-0.00565247,-0.018803492,-0.062131982,-0.05158056,-0.00709383,0.059929546,0.03090369,-0.037747703,0.008106952,-0.037494455,0.07525734,0.026861113,-0.014177448,-0.040726732,-0.050549682,-0.0012327112,0.009898706,-0.029141026,0.1174092,0.09695985,0.088684216,0.046155497,-0.029253168,0.1188664,-0.021217747,-3.8389234e-07,-0.013038986,-0.10245932,0.019523235,0.02645019,0.02789269,-0.010327443,0.055775687,-0.042831752,-0.01987303,0.010259782,-0.022707144,-0.080868624,-0.08638025,-0.015193796,0.08592959,0.03407549,0.01210935,0.1354752,0.029339155,0.057239342,0.04502863,-0.04613814,0.031201413,0.009294576,0.038917102,0.00718725,0.03065152,0.08414337,0.010087895,-0.026094096,0.1042868,0.0082727885,-0.038623724,0.033822123,0.07080179,0.041291595,-0.11215934,-0.038587943,-0.01936738,0.047492012,-8.989481e-34,0.07235131,-0.05608874,-0.017011343,-0.088255204,-0.026548928,0.07417726,-0.010671863,-0.024689706,0.04092111,0.005689021,0.0793273,0.027216148,-0.0046141567,-0.084474154,0.052532002,0.0047505903,-0.03169235,0.026325919,-0.08123841,-0.011569199,0.07532641,0.008896678,0.02321627,0.10778943,0.064219154,0.042654775,0.038866494,-0.004204439,0.029299032,0.035879284,-0.034912925,-0.020948924,-0.0014862254,0.028531738,0.034694403,0.06480784,-0.08727636,0.052027326,-0.01706865,0.0062899496,-0.042572904,0.0072422056,0.07401187,0.066506624,0.059389096,0.023104507,-0.06568344,0.026385034,-0.0369549,-0.025108282,0.0002229607,-0.033050228,-0.026243059,0.0029595622,0.07182834,0.07717612,0.0051250006,-0.0018952555,0.03331874,-0.0531931,-0.07437614,-0.032582436,0.041057963,-0.030160008,-0.031791203,0.023264458,-0.02836984,-0.03053303,0.038667,0.013496457,0.090736896,-0.028314993,-0.018132336,0.006925739,-0.010185537,-0.09192025,-0.035645466,-0.059549417,-0.04671901,0.023640161,-0.0027963968,0.014201264,0.018497787,-0.06817969,-0.045944016,-0.028320087,0.011412284,0.060199168,0.0076469374,0.053153474,0.0048660287,0.011926459,-0.06782926,0.040816724,0.020516332,-3.1837413e-08,-0.0008823121,-0.07032333,0.1212379,-0.0022899716,-0.010203436,0.058577124,0.056538086,0.021448685,0.084461935,-0.013169074,0.07637188,0.064050265,0.038944136,0.024455765,0.052333705,-0.07081061,-0.057711776,0.040422577,-0.003286515,-0.029649131,-0.079817556,-0.05312901,-0.07476251,-0.0011109625,0.06194419,-0.07937672,-0.0027773997,-0.012517787,-0.011139904,0.00019473668,0.026488248,0.012029201,0.056643166,-0.0425957,-0.008252881,0.004417371,0.011440814,0.0053721205,-0.07478374,0.08370531,-0.04875426,-0.060348876,-0.031856183,0.029914632,0.0625235,0.019463921,-0.07180328,-0.0012709423,0.00093808165,-0.013562733,0.004640067,-0.009097691,-0.014046738,0.010540793,-0.103144474,-0.055638537,-0.017509311,-0.08209634,0.005276937,-0.023127826,0.016451694,0.07070297,0.18180844,0.016469147 +1.1.1.281,"This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.",384,1.0,-0.027416155,-0.07807329,-0.08668402,-0.04653916,0.056174334,-0.0019141067,-0.040361714,0.072468676,0.00437589,-0.018916786,0.029934198,-0.047780637,-0.0653014,-0.013616374,-0.058298502,-0.020269338,-0.033424754,-0.004602961,-0.038448945,-0.02151691,0.05989067,0.017803593,-0.029930243,0.010936096,0.035661444,-0.00049255457,0.10119059,-0.010006567,-0.034131795,-0.09719007,0.028049301,-0.075331606,0.11779639,-0.04548998,0.028149389,0.08257696,0.028940003,-0.027755978,0.010046107,0.047894917,0.008473036,-0.011785462,0.037727736,-0.03587975,-0.033088043,0.04803153,-0.10948258,0.11874569,0.059862882,-0.030798303,0.011280509,-0.05362457,-0.05451394,0.047156125,0.04317744,0.0012435925,-0.041882396,0.046189614,-0.07850549,0.015754143,0.05276658,-0.015256562,0.029093415,-0.006663962,0.0069135064,-0.011634277,0.053508215,-0.07623772,-0.025949234,-0.028823461,-0.049054846,-0.07042484,-0.03765469,0.035844065,-0.05150395,0.05748494,0.021357505,-0.06674388,0.035434652,-0.06642692,0.07973227,0.047254726,-0.0024055217,0.01056456,0.014078985,0.019286942,-0.024593139,-0.023788946,0.058317374,0.021977607,0.0336246,-0.048336923,0.014402485,-0.02777256,-0.09766771,0.058461398,-0.018599898,0.08014243,0.08009794,-0.039604556,-0.046509314,0.06496664,-0.064353526,-0.06826628,-0.0996114,0.03787788,-0.026777018,0.014608009,-0.010910877,0.02902389,0.022071002,-0.00013004134,-0.016563011,-0.008964426,-0.10181511,-0.045511965,0.003873578,-0.07750842,-0.116076045,-0.0056506125,0.03944413,-0.021780714,0.094335705,0.033837833,0.017387582,0.007759572,-0.077788375,1.6595966e-34,-0.015953107,-0.008950998,-0.025541328,-0.0361178,0.0039856443,0.007007901,-0.10414226,0.074272975,-0.043085374,-0.01741891,-0.07165317,-0.029750654,0.019368872,-0.018707486,-0.025230734,0.05582461,0.052295793,-0.014118232,0.012245265,0.040461626,0.02300274,0.06197949,-0.026953114,-0.0004969733,0.059743464,0.010556569,-0.031113597,-0.00372399,0.062094722,-0.03398857,-0.032348156,-0.07607508,-0.059939675,0.042436894,-0.015731495,-0.019170579,-0.04803107,-0.056128476,-0.02714272,0.023424009,0.036188744,0.03927308,0.018452154,-0.051564254,0.02618444,-0.0023469608,-0.037046872,0.009365197,0.07591498,0.07729192,0.0074348836,0.025410078,0.06818758,-0.04933621,-0.032528635,-0.08011039,-0.07191543,0.038502604,0.07158598,0.062033772,-0.03458657,0.11799405,-0.05874523,-0.020789403,0.0054583494,-0.007211231,-0.031578217,-0.06565759,0.0019426454,0.062588856,0.02741091,-0.066995606,0.051242333,0.02675976,0.049612828,-0.08923721,0.024629632,0.025160246,0.039755307,-0.011125159,-0.100406684,0.051998813,-0.008636245,-0.038012687,-0.035246417,0.0076509407,-0.05556429,0.013219799,0.00857907,0.03631516,0.0157059,-0.064128935,-0.096600585,0.041798662,0.035410855,-2.762963e-33,-0.021607224,-0.073697746,0.02490341,-0.03757076,0.010066446,0.0986283,0.06814461,0.051249865,0.041500967,-0.040379424,0.11509787,-0.025779936,-0.06204366,0.008579752,0.07397927,0.024368508,-0.035103384,0.03924551,-0.020882426,0.0007571267,-0.060961377,0.10514899,0.024437971,0.06818326,0.032664493,-0.009041268,0.022790676,0.11154508,0.039288864,0.008673574,-0.00315636,0.04982534,-0.06945478,0.024106922,-0.09376594,0.06714627,-0.055074666,7.7309975e-05,-0.008672261,0.062067136,-0.013119076,0.10291804,0.023910366,0.038881596,0.0054019904,0.053879704,-0.08086899,0.0723047,0.052717708,-0.06458016,0.04591763,0.023424149,0.008350197,0.040070746,-0.00071735494,0.03596992,0.018076038,0.061367538,-0.03812701,-0.026996715,-0.04909664,-0.11931741,0.004855911,0.018745467,0.01324242,0.059665687,0.014559494,0.01968295,0.07460478,0.0046164426,0.059290275,-0.0022603753,-0.009181858,0.013687738,-0.043901294,-0.07679745,-0.055733547,-0.058917943,0.02035721,0.0019829345,0.059631173,0.016466314,-0.0075372444,0.009809526,0.010783846,-0.030888192,0.023423472,0.057381913,-0.027513059,0.077228054,-0.025654243,-0.016396824,-0.094542116,0.06815102,0.09848745,-3.757404e-08,0.08113602,-0.07817566,0.0711592,-0.05086485,0.086126484,-0.03853928,-0.042543344,-0.010520017,0.03186073,0.019838283,-0.00025514263,0.112056464,-0.03467215,-0.0014768483,0.030242072,0.0010668036,-0.06649786,0.05992869,-0.00893645,0.08363717,0.004864066,0.011589676,-0.18067671,-0.06120657,0.0019181452,-0.032555956,0.05921216,0.024920722,-0.05489968,-0.033902977,0.07101366,0.029714867,0.030180527,-0.0030178004,-0.052482177,-0.092163354,-0.021855619,0.019916086,-0.06405383,-0.014562693,0.008002993,-0.06442814,-0.039714318,0.025137994,-0.079398245,-0.015138365,-0.03084126,-0.025519442,0.024843136,-0.0027255039,0.022289557,-0.027528087,0.0072115217,-0.118330576,-0.048187297,-0.061698876,-0.017101092,-0.035436194,0.0065190415,-0.048040576,0.06250097,-0.009423346,0.1934312,0.0063786786 +1.1.1.282,"This is the second shikimate dehydrogenase enzyme found in Escherichia coli. It can use both quinate and shikimate as substrates and either NAD+ or NADP+ as acceptor. The low catalytic efficiency with both quinate and shikimate suggests that neither may be the physiological substrate. cf. EC 1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC 1.1.5.8, quinate/shikimate dehydrogenase (quinone), and EC 1.1.1.25, shikimate dehydrogenase (NADP+).",384,1.0,-0.10291566,0.014024147,-0.101379335,-0.053343326,0.03232331,0.044826616,-0.055309895,0.02576083,0.051486284,-0.021590617,0.05100298,-0.054649256,-0.026054693,0.01517781,-0.038773663,0.03668097,-0.014220388,-0.0360462,0.05403554,-0.060562,0.028907355,-0.019665191,-0.033943035,-0.061771248,0.044751506,0.03830881,0.065912515,-0.001235612,-0.042360324,-0.06879036,0.00037954797,0.008294593,0.006287634,-0.012881348,-0.052749738,0.1421783,-0.06254273,-0.030964969,0.030065613,0.008278164,-0.0103097875,0.032688394,-0.021050382,-0.062419277,0.0025062065,-0.013842044,-0.017803282,0.032627594,0.013603318,-0.06301015,-0.066614375,-0.0034248885,0.078764826,-0.015287781,0.10948607,-0.06726823,0.024016894,-0.08806329,-0.07746077,-0.014622282,-0.007751495,-0.015384487,-0.014962025,-0.03950172,-0.00016135746,-0.08923752,0.02797068,-0.023407089,0.020425161,-0.1097378,-0.100352526,-0.020607246,-0.0014700862,0.018259248,-0.019361675,0.042256925,-0.0049854782,-0.047341753,0.052780055,-0.022645723,0.00889809,0.03510004,0.013791071,0.04756306,0.039619055,-0.0016819396,0.0380836,0.0013435177,0.026381155,0.062364448,0.023035977,0.011913742,-0.0019346138,-0.025428021,-0.056417983,0.046445917,-0.0054114927,0.026844917,0.020446662,-0.07770409,0.054059025,0.08240643,-0.032485764,-0.046058375,-0.07476378,-0.016276987,-0.0040646736,0.15844823,-0.015717776,-0.031964462,0.015477958,-0.02921677,-0.0011647306,-0.015806777,-0.048787773,0.13756955,0.027518097,-0.053402282,-0.03385417,0.01936212,0.001243576,0.026612334,0.029834613,0.042490765,0.025121232,-0.011392411,-0.10717499,2.8100145e-33,0.06779117,0.059439313,-0.028691266,-0.021693004,-0.05040019,0.0006651892,-0.10836872,0.020769777,-0.100691356,-0.08149314,-0.043701295,-0.010666261,-0.0134267695,-0.017109185,-0.006548992,-0.0059053907,-0.037595596,-0.049132247,0.03315518,0.04853446,-0.012365106,0.06673707,0.012108482,-0.04793852,0.030502653,0.031410776,0.03636743,-0.019044157,-0.024208698,-0.01760834,0.04754404,-0.05530612,-0.0721247,0.046754308,0.08560744,-0.014217774,-0.018424992,-0.004182455,-0.08272822,0.10094731,0.05080062,0.057654653,0.054000095,0.025025921,0.052711654,-0.060200844,-0.012759373,0.07069373,0.047307387,0.07704944,0.03283272,0.07182602,0.14416088,-0.120635815,-0.08763357,-0.0081930645,0.01780216,-0.008398,0.041227438,0.08089022,-0.008536663,0.053680193,-0.07677689,0.037136357,-0.004409351,-0.047552243,-0.07829453,-0.05370822,0.046055067,0.14305142,-0.009609193,-0.026604256,0.11489635,0.051864788,0.049843043,-0.091222085,-0.014575746,-0.006681974,0.014529203,0.028915416,0.014330436,-0.041870642,-0.014156842,-0.008125787,-0.055312343,0.015277223,-0.039922867,-0.03589136,-0.049182683,0.0689629,-0.012467131,0.0020384027,-0.036430728,0.0022163482,0.062494602,-4.4849106e-33,0.055917762,-0.052548144,-0.0063388576,-0.06447095,-0.06372251,0.1382752,0.029457089,-0.04407147,-0.005536786,-0.010763776,0.11083853,-0.014527894,0.094164506,-0.0053205006,0.008295559,0.02034497,-0.043362148,0.041359387,-0.06940996,-0.015068935,-0.0124916,0.10869164,0.029564824,-0.0028327138,0.06987214,0.037359696,-0.023227587,0.05363999,-0.0025857338,0.023807524,-0.007018858,-0.0036370778,-0.015816893,-0.0013791511,-0.008323324,0.037406158,-0.05547607,-0.045856703,-0.022374976,0.0040679676,-0.002632589,0.043677572,-0.0022526227,0.09108537,-0.023279604,0.05386317,-0.06786224,0.01689424,0.042811785,-0.07806782,-0.0027921097,0.054464467,-0.05510892,0.017719075,0.048947793,0.022941647,-0.014948248,0.025977932,0.07777837,-0.0024900686,-0.008417037,-0.05609948,0.04103101,-0.029997285,0.012049062,0.01453044,0.019441921,0.025103463,0.011651961,-0.009470573,0.05851302,0.042262178,-0.021445204,-0.0038908562,-0.035546046,0.015580031,-0.04777717,-0.0020557484,-0.024512714,0.01823903,0.07312996,-0.01930625,-0.033623558,-0.041436806,-7.04323e-05,-0.081485055,0.041132633,0.07102639,-0.0365402,0.022577448,0.01844592,0.052992776,-0.07930512,0.020265985,-0.013504318,-4.1303707e-08,0.0061729406,-0.13840136,-0.04044281,-0.061327543,-0.008150526,0.018879041,0.0020865165,-0.052712638,-0.0054142196,-0.008081122,0.0030605847,0.10905363,-0.026793191,0.029331012,0.09784515,-0.013717076,0.008486902,0.014426579,-0.006472567,0.0049653673,-0.062322423,-0.0052952953,-0.11990713,-0.017863253,-0.025039157,-0.023082905,0.025867999,-0.010216667,0.045661107,-0.12720262,-0.055448595,0.035523303,-0.017563619,-0.039342012,-0.019975899,0.06257064,-0.03854947,-0.01268704,-0.041672926,0.031726174,0.052181777,-0.07610878,-0.080595344,0.020806944,-0.020308014,0.048611984,0.04300893,-0.04325535,-0.05047453,0.012214895,0.03991421,-0.045008022,0.12807834,-0.027142735,-0.11688793,0.06652024,-0.012634191,-0.14131746,-0.010858362,-0.03737673,0.05586542,-0.013790518,0.14883329,0.036555983 +1.1.1.283,"The enzyme from the yeast Saccharomyces cerevisiae catalyses the reduction of a keto group in a number of compounds, forming enantiopure products. Among the substrates are methylglyoxal (which is reduced to (S)-lactaldehyde) [1,2], 3-methylbutanal [3], hexane-2,5-dione [4] and 3-chloro-1-phenylpropan-1-one [5]. The enzyme differs from EC 1.1.1.78, methylglyoxal reductase (NADH), which is found in mammals, by its cosubstrate requirement, reaction direction, and enantiomeric preference.",384,1.0,0.017534265,-0.021826966,-0.073016144,-0.039628696,0.05008135,0.060938016,-0.068096235,0.035087693,0.027292086,0.020096378,-0.009477505,-0.0620693,-0.08529838,-0.02424657,-0.03915188,0.021148175,-0.016598592,0.015000252,0.045378618,-0.05918287,0.06871439,-0.034032118,0.0061570765,0.048144806,0.059221044,0.010686902,0.039717626,-0.005883721,-0.08493027,-0.15122852,-0.03265801,-0.0074648303,0.07093917,-0.068718046,0.028522836,0.07634717,-0.04314992,-0.034508377,0.03756029,-0.016221456,-0.010368653,-0.029516147,-0.0968332,-0.01571715,-0.043561768,-0.032793593,-0.0034996422,0.02287282,0.067219645,-0.054868322,-0.013033881,-0.041635536,-0.0317889,0.0418284,0.026562387,-0.041005522,-0.04104093,0.0060059293,-0.018033609,0.025594918,0.0618558,-0.037171856,-0.033395242,0.015668811,0.00039709482,-0.058313638,0.07140491,-0.08958166,-0.01933057,-0.045856446,-0.07094769,-0.062262464,-0.028857244,0.07132836,-0.004648768,0.056752827,0.052835103,-0.025454769,0.032339584,0.008594896,0.059283074,0.068016544,0.015915226,0.021215934,0.08613339,-0.0259751,0.019842006,0.020697076,0.0397531,-0.010686093,0.032138098,0.025717128,-0.018424436,-0.030865109,-0.053382657,0.037737135,-0.04033723,0.09487161,0.03401014,-0.037748545,0.03479931,0.07503294,-0.0074549727,-0.066278465,-0.007867243,0.061068527,0.037924014,0.114375435,0.04479839,0.0067548756,-0.06082414,-0.06031717,0.054660503,0.027184267,-0.06480177,0.09499336,0.0820758,-0.03414097,-0.043710865,0.014943331,0.029905656,0.029356286,0.11544757,0.000850063,-0.040867884,0.039397046,-0.09314604,6.0440765e-34,0.07614693,0.04498529,0.0052517233,-0.018529026,0.043714732,0.017057199,-0.07971518,0.060724415,-0.034450658,-0.049302,-0.05881466,-0.014750717,0.040115554,0.054087076,0.030824864,-0.014723308,-0.028373789,-0.01806956,0.03496944,-0.022143064,-0.0803491,0.014505944,-0.088305585,0.021145603,-0.033515573,0.010299765,-0.055955008,0.04536443,-0.029502803,-0.020476745,0.01215249,-0.0696447,-0.09946006,0.030826474,0.024100628,-0.0014199631,0.013700643,-0.005335326,-0.0005253495,0.08472612,-0.016207084,0.072319455,-0.0068416786,-0.042972736,0.008687788,-0.056567993,-0.04388331,0.04657916,0.09126303,0.06711515,0.05561477,-0.040683042,0.102019034,-0.05325196,-0.020729125,0.0791619,0.0031139364,0.027912242,0.035231173,0.041677825,-0.040938586,0.0838298,0.037386168,0.037175763,0.0039530564,-0.011757109,-0.10513281,-0.04330463,-0.08911791,0.044718273,-0.07234587,0.025676863,0.077545516,-0.0037660247,0.026401903,-0.06317257,-0.08220318,-0.020358527,-0.031107921,0.010390884,0.010811852,-0.011265549,-0.0562797,-0.052219085,-0.02927013,0.006929274,-0.05471248,-0.035777096,0.030178623,-0.0009148046,-0.007876408,-0.08218949,-0.07026317,0.004886553,0.033266876,-2.3886872e-33,0.09297984,-0.059523456,0.088363305,-0.08074081,-0.050727356,0.11424916,0.07945244,-0.029762786,0.025126342,0.0045723473,0.050003666,-0.0075001586,0.09885601,-0.026923854,0.040604316,0.0038745124,-0.03830253,0.0616432,-0.014258665,-0.061211064,0.0145382965,0.11960964,-0.065203205,0.026872003,0.081336565,0.008675524,-0.058705807,0.05476265,0.07880161,-0.05511242,-0.045973446,-0.045726605,-0.03510927,-0.011837334,0.004094402,0.103753686,-0.124707356,0.008252396,0.00025456105,0.10058851,-0.06570405,0.06526115,-0.023578554,0.021399658,0.03688132,0.060160577,-0.072497495,-0.024720993,0.049213983,-0.07476413,0.03233132,0.043353487,-0.062539585,0.021152351,0.044990584,0.024082154,-0.008084968,0.022189757,-0.030885594,-0.0027183385,-0.004157654,-0.021471208,0.04414779,-0.031567235,0.011745472,0.028120756,-0.057519075,0.015808778,0.02995085,-0.0038682094,0.048866242,-0.02338468,0.022113128,0.047717374,-0.017454583,-0.042599913,-0.050997466,-0.058105588,-0.060206525,-0.025502484,0.046531174,-0.028022453,0.0068466486,-0.054689974,-0.040658727,-0.03598423,-0.014126116,0.025470914,-0.03712199,0.050422996,0.009644986,-0.010160242,-0.04444501,0.14719859,0.043127302,-5.0622024e-08,0.09382083,-0.06549339,0.062847055,-0.036245618,-0.003306509,0.031424858,0.036880754,-0.015531639,0.026056372,-0.07542113,-0.055496175,0.07139118,0.036445443,0.08975958,0.0618366,0.002091078,-0.014650877,0.0014064106,-0.001563333,0.029945934,-0.033874948,-0.053511377,-0.11639688,0.047408417,0.028194647,-0.071673766,0.032221984,0.07069471,-0.012788902,-0.034234304,-0.012300362,0.050220538,0.047171723,0.018650511,-0.040403403,0.039033968,-0.1172541,0.027769266,-0.071810864,0.047276374,0.026288942,-0.06403301,-0.06311135,0.03231158,-0.02106639,0.0042834515,0.068630055,0.027682744,-0.012224314,-0.031160012,-0.0027320934,-0.005905702,-0.02835081,-0.040740352,-0.08155586,0.053590864,-0.03694596,-0.02644111,0.04046533,-0.1111315,0.020385142,-0.001639408,0.18265826,-0.04086378 +1.1.1.284,"The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase. This enzyme forms part of the pathway that detoxifies formaldehyde, since the product is hydrolysed by EC 3.1.2.12, S-formylglutathione hydrolase. The human enzyme belongs to the family of zinc-dependent alcohol dehydrogenases. Also specifically reduces S-nitrosylglutathione.",384,1.0,-0.045206465,0.011504021,-0.055687908,-0.0015035637,0.099105194,0.054703742,-0.06802189,0.029703356,-0.035540547,-0.030619718,0.009790208,0.016521722,0.0053045484,0.028308647,-0.054628648,0.009202656,-0.03973388,-0.026133075,-0.03262125,-0.057037577,0.02640264,0.0070983428,-0.06496688,0.005416437,0.081466004,-0.0189986,0.023397118,-0.014993978,-0.02779031,-0.018590184,0.03402185,-0.051049564,0.037119985,-0.038233005,0.057418983,0.013807792,-0.037854142,0.025643008,0.04014544,0.000995117,-0.012660752,-0.016455792,-0.032963555,-0.050653115,0.0025039923,0.04471116,-0.023371844,0.017876951,-0.027234357,-0.01869516,-0.031401988,-0.04813081,0.03988864,0.023079855,0.0758881,-0.06840738,0.015024793,-0.054438457,-0.08055206,0.027851267,0.025063593,-0.09117337,-0.055122077,-0.072557636,0.078835,-0.00201614,0.054712024,-0.07233556,0.0091533065,-0.044424623,-0.08785761,-0.054267645,-0.009422583,0.06644172,-0.07923806,-0.030280156,-0.034451295,-0.061701555,0.062880844,-0.005080007,0.07079995,0.005434095,0.034335338,0.115902804,0.047423117,-0.035683632,-0.1077214,0.025746308,-0.004696805,0.056694593,-0.061040655,-0.020253344,-0.033633463,-0.045181584,-0.07546979,0.09587844,-0.051334802,0.058047775,0.017068285,-0.02116016,-0.01544893,0.036223274,-0.04732319,-0.07009451,-0.05868066,0.040546935,0.047557406,0.10386148,0.022526223,-0.008266611,0.034490664,0.017925031,-0.035594348,0.03179553,-0.02876423,0.08289387,0.12244925,-0.026004676,-0.11131217,-0.03724438,0.006880954,0.039562795,0.09399418,0.0014936633,-0.0020860562,0.04190979,-0.009215804,2.4400708e-33,0.059892874,0.074438944,-0.05064098,0.024940586,0.04137004,-0.005341456,-0.071025155,0.05578216,0.06167088,-0.028215675,-0.0764983,-0.03883967,-0.04513331,-0.049251266,-0.05271516,0.021829696,-0.047730528,-0.007993775,0.048917573,0.01701146,0.025250953,-0.025997924,-0.06036699,-0.016479446,0.010839799,0.041918106,-0.005606198,0.026663579,-0.022537738,-0.010461172,0.029535837,-0.03687556,-0.056451548,-0.0012279978,0.080567546,-0.008198796,-0.03613928,0.0031511008,0.014280091,0.016925622,0.022036292,0.05320623,0.0040925876,-0.02853929,0.035987522,0.0185419,-0.10024267,0.07135666,0.016229946,0.056024387,0.044126906,-0.027248269,0.07759066,-0.023446837,-0.09894945,0.030055473,-0.0024631515,-0.08378714,0.036592882,0.06240883,-0.014090063,0.09618158,-0.05251324,0.010014539,0.03885412,-0.029436544,-0.0350499,-0.008160662,-0.044594873,0.054301947,-0.019385437,-0.027675357,0.039780002,0.06981022,-0.013716133,-0.058005948,-0.042035114,0.07484376,0.019760815,-0.01544285,-0.012024732,0.0419247,-0.024433877,-0.013149875,-0.013375617,-0.027812535,0.0068547637,-0.057445373,0.02374959,-0.038997013,0.034616515,-0.08694043,-0.016239395,0.01907294,-0.010246852,-3.411069e-33,0.07516266,-0.07951306,-0.0064571416,-0.074745774,0.029348264,0.07528216,0.034990277,0.029140038,0.06010936,0.02713036,0.10602582,0.02630508,-0.006906607,-0.017887184,0.06893747,-0.05447774,-0.023164468,0.057368204,-0.062491126,-0.07171907,0.03814196,0.09569342,0.044639878,0.03766978,0.057026904,-0.017611964,-0.0040188897,0.072205044,0.115145214,0.10799412,0.002986897,0.035380345,-0.014251927,-0.06441958,0.07152572,0.02935867,-0.093691826,0.053700477,-0.015264642,-0.04921666,0.053255424,0.036217373,-0.0038849192,0.084715396,0.089508004,0.09460976,-0.16646814,-0.040625427,-0.019642107,-0.055460304,0.0722055,0.005172455,-0.06163502,-0.001989888,0.04186782,-0.0016441059,0.019519078,-0.036598608,-0.06390767,-0.008023467,-0.07819878,-0.041224483,-0.03672004,0.020952743,-0.025767995,0.0026168355,0.020377686,0.06413761,0.06290299,0.022303425,0.009266155,-0.04459104,0.013293124,0.046809822,-0.093384355,-0.01979436,-0.073449194,0.022111902,0.041287106,-0.0017693269,0.03023714,0.03160994,-0.001730868,-0.035843544,-0.0032619135,-0.14375342,-0.0017124019,0.14548945,-0.007611461,-0.0050100847,-0.056452002,0.010070246,-0.079650745,-0.0082598645,-0.086386696,-4.233716e-08,-0.021877516,-0.053583145,0.0966521,0.0333035,-0.028634185,0.017764872,0.046904214,0.052437548,0.08470587,-0.07484697,-0.0018102296,0.1353846,0.015276719,-0.0059107323,-0.033730548,-0.04115464,-0.014856412,0.038033355,-0.009954211,0.0015434423,-0.07481118,0.0017047264,-0.078314304,-0.0108336555,-0.009496022,-0.039807383,0.01752833,0.038420796,0.05419167,-0.04795207,0.028388567,0.039586443,-0.015355058,0.04657173,-0.12926397,-0.037909057,-0.01924811,0.002744841,0.053776823,0.00814577,-0.039546177,0.007411923,-0.075518645,0.035737965,0.03113414,-0.014200085,0.0026907194,-0.0074427957,-0.052190285,0.061623942,0.0417255,-0.010463031,-0.02645242,-0.009980214,-0.096792296,0.00019607885,0.010108274,-0.07755552,-0.02566569,-0.100189455,0.043846924,-0.00027411172,0.17697953,0.07040771 +1.1.1.286,"Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.",384,0.99999994,-0.050363198,-0.02793369,-0.0683025,-0.076084435,0.06128843,0.015407558,-0.123413675,-0.03317412,-0.02238382,0.013302882,0.10193269,-0.08588121,-0.044438675,0.020464165,0.047124214,0.00064051,-0.092914306,-0.028775439,0.026568122,-0.033880327,0.058095265,0.045119263,-0.034568004,-0.08442783,0.053914133,0.03171362,0.02918216,0.018099822,-0.0069987066,-0.041132525,0.0023690092,-0.08271302,0.10596817,-0.0982428,0.017163599,0.087775625,-0.10313289,-0.055642415,0.0459865,0.05082165,0.02722811,0.014834042,0.026979532,-0.053776596,-0.057504814,-0.06337183,0.094454885,-0.0060107037,-0.013009955,0.0012460485,-0.014028825,0.010153863,-0.032014605,0.0069724037,0.006065111,-0.029731328,-0.064429626,0.029897265,-0.044718523,-0.092071556,-0.022578789,-0.034548447,0.019368468,-0.049329657,0.05829584,-0.053225774,0.082093716,-0.074289694,0.0819266,-0.047556613,-0.07213956,-0.04964965,0.01821341,0.06196341,-0.0434107,0.085141435,-0.027025659,-0.029882533,0.021094482,-0.055681262,-0.016110461,-0.061043724,-0.029350933,0.03819986,0.061375875,0.026179997,0.013386147,0.0044883145,-0.009826288,0.02385388,0.044244897,-0.0027130975,-0.011491853,-0.016940834,-0.036613062,0.03582423,0.029692959,0.105741106,-0.036614653,-0.05195007,-0.0073265694,0.08141454,-0.1263392,0.04064287,0.0053150244,-0.00625579,0.055165358,0.08474938,-0.028943943,0.054661375,0.02368277,0.02065593,0.0069226483,0.009217209,-0.0026692604,0.022660924,0.02830538,-0.07556384,-0.059226774,-5.6092e-06,0.065649875,-0.054555606,0.020736925,0.05433115,-0.034700792,0.008066567,-0.07465964,4.4290394e-33,0.045736887,0.0069977706,0.0040898123,-0.060904875,0.031871475,-0.00651529,-0.1102366,0.017473718,0.02602196,-0.06515116,-0.109048456,-0.0018208772,0.08537444,0.07184337,-0.0885039,-0.021035014,-0.028971566,-0.030976264,0.09767169,0.03832609,0.04304364,0.024746506,-0.024869073,0.06336974,-0.010554101,0.049009997,0.05145487,0.039973564,-0.022514986,0.010373161,-0.024577813,-0.18496028,-0.09938954,-0.04916851,0.06969092,0.023045195,-0.0465898,-0.025881706,-0.015166146,0.00470965,-0.062730365,0.045818478,-0.067308664,0.020003203,0.052915644,-0.0032151367,-0.00883158,0.087458774,-0.016319783,0.060250137,0.011108323,-0.043976698,0.06324525,-0.05704587,-0.043154605,0.015325325,0.023512568,-0.01674373,0.041852858,0.101050116,0.006139258,0.10254426,0.0059640827,0.072432384,0.020321026,0.0035001228,-0.06562669,-0.113474146,0.0697816,0.023776568,-0.023430334,-0.04878444,0.08241338,0.002011258,-0.029983107,-0.017346583,-0.06958545,-0.023570774,0.016111432,0.016068779,-0.03142979,-0.004906135,-0.024683228,-0.04967104,-0.04409227,0.03114651,-0.046164747,-0.039945893,0.04519732,0.03851591,0.024893837,0.008928681,0.031082798,-0.0105500175,0.022898,-5.1466188e-33,0.044893585,-0.027555726,0.016641224,-0.09663687,-0.0598869,0.15396544,0.035293315,-0.038102623,0.019031718,-0.030422457,0.09768186,0.0046568904,-0.013064042,-0.012327828,0.06171015,0.011473157,-0.05745294,0.095725216,0.054457903,0.05100814,0.018414825,0.06484935,-0.0066469163,0.035184648,0.06237131,0.016279196,-0.0008310469,0.068435475,-0.033108782,0.0002775198,-0.055760954,0.027747808,-0.058285646,-0.078055896,0.016114134,0.0574911,-0.055897526,0.0073290304,0.026693428,0.013497463,0.013700353,0.03367428,0.012755195,0.038464755,-0.004247699,0.017796362,-0.076381005,-0.0039365334,-0.007540586,-0.017083133,0.045493286,0.055444963,-0.07926673,-0.043305136,0.05998447,0.02456955,-0.014889559,0.06312575,0.026804721,0.012773589,-0.04692697,-0.07181488,0.020707842,0.04425493,0.04067677,0.014501341,0.055559352,0.026854532,0.00078823295,0.043819733,0.07143345,0.01608348,0.0834345,0.026083594,-0.040051382,-0.04177352,-0.06606556,-0.018264866,-0.020378554,-0.0444826,0.046043206,0.015893048,-0.029083101,-0.06653584,-0.007956766,-0.038213536,0.01899093,0.062710844,0.013390884,0.042175267,0.017874205,-0.045649864,-0.05818052,0.07923568,0.024647214,-4.3862425e-08,0.0031315186,-0.055470165,0.04340779,-0.028934177,0.006676727,0.043409813,-0.012047907,-0.059833948,0.08629639,-0.029581478,0.10998226,0.060763333,0.0030653873,0.028837366,0.06288205,-0.0043757698,-0.044548195,0.07234896,-0.027630895,-0.0032324034,-0.04047594,-0.004825773,-0.14653884,0.036715467,0.07466332,-0.025252497,0.015105635,0.017324582,0.025813846,-0.076168634,0.010392537,0.024745436,0.040794767,-0.0415546,-0.06112901,0.01597559,-0.03545057,0.028226975,-0.061474144,0.027445,-0.069300056,-0.07850884,-0.057934493,-0.0046731527,0.026165834,0.025089722,-0.014320998,0.0018429123,-0.072703175,-0.018508175,0.028056934,-0.027128562,0.061861854,-0.06274666,-0.074540354,0.051912047,-0.056874238,-0.08723437,-0.05726588,-0.037269782,0.09680062,0.022704495,0.12988515,-0.050191768 +1.1.1.287,"The enzyme from the rust fungus Uromyces fabae can use D-arabinitol and D-mannitol as substrates in the forward direction and D-xylulose, D-ribulose and, to a lesser extent, D-fructose as substrates in the reverse direction. This enzyme carries out the reactions of both EC 1.1.1.11, D-arabinitol 4-dehydrogenase and EC 1.1.1.250, D-arabinitol 2-dehydrogenase, but unlike them, uses NADP+ rather than NAD+ as cofactor. D-Arabinitol is capable of quenching reactive oxygen species involved in defense reactions of the host plant.",384,1.0,-0.08875558,-0.0016849035,-0.03741389,-0.039448354,0.041691102,0.048173923,-0.06395236,0.043906968,0.09529581,0.060840633,-0.021838073,0.004490709,0.006250967,-0.010322171,-0.10165348,0.027607545,0.018415645,0.081724696,-0.022052186,-0.040316183,0.064104535,0.039694067,0.03521529,-0.09762607,0.07466362,-0.008000487,-0.003528784,0.036518514,-0.0718235,-0.11124254,0.0024524096,0.003494786,0.010733918,-0.07865908,-0.0057531507,0.08965802,0.050756857,-0.06138161,0.03488907,0.008607481,-0.003210316,-0.018576412,0.017182648,-0.010166601,-0.111110665,-0.020174172,-0.019308517,0.067823194,0.07875501,-0.03464263,-0.058338046,-0.028116703,-0.008625477,-0.024573008,0.05998567,0.021576736,0.043983396,-0.0059529343,-0.048613947,-0.04705657,0.035962664,-0.05425315,0.0268802,0.006854347,-0.060577728,-0.028664539,-0.036115956,-0.060180254,-0.012843848,-0.0534314,-0.10263348,-0.021552792,-0.044143457,-0.007654239,-0.01885735,0.0638202,-0.058975097,-0.086229615,0.021692691,-0.01731626,0.049500898,0.03069155,0.04024906,-0.0147560295,0.035554986,-0.028443968,0.038293418,-0.00970957,0.039265983,0.08777589,0.051787317,0.010867506,0.02146044,0.00917067,-0.045042906,0.017158382,0.06532744,0.06152248,-0.03535141,-0.07838459,-0.004103609,0.025851449,-0.019487146,-0.07485082,-0.028998949,-0.05637514,-0.033204187,0.10049229,-0.037720717,-0.078465566,0.004274956,-0.05475669,0.0072918553,-0.01483967,-0.07659131,0.00080660626,0.06066313,-0.092521906,-0.053344823,-0.088052124,-0.0041523664,0.0028826704,0.050119873,0.0069594244,0.024110498,0.011427796,-0.06303104,1.5091266e-33,0.09038595,0.0025582078,-0.099138685,0.0030554847,-0.005023841,-0.020313233,-0.032738972,0.03126084,0.01123237,-0.01387034,-0.12133098,-0.00086215994,0.028854178,-0.036792036,-0.05330127,0.07187795,-0.015142817,-0.057872403,0.019865088,0.033886395,0.10444971,0.0361199,-0.006170585,0.03356622,0.033992436,0.040915474,0.035352662,0.009923118,-0.003516111,0.0025378962,0.014119844,-0.101023145,-0.08892613,0.009608025,0.033931367,0.0335389,-0.06558317,0.02889191,-0.05820734,0.026486067,-0.091336794,0.040734757,-0.0017872066,-0.038049478,0.0940549,-0.036493607,-0.040741462,0.09442889,-0.022511091,0.11147729,0.055215344,-0.00040136787,0.12482354,0.038077068,-0.035129674,0.029485766,-0.04612952,-0.014877004,0.00089115475,0.09840854,0.011758935,0.08439484,-0.0046612155,0.07116984,-0.024567407,0.035827994,-0.048527457,-0.057390895,0.036674555,0.10255137,0.009447763,-0.0033640706,0.048644237,0.013740503,-0.01084728,-0.027342483,-0.014963189,-0.034477893,0.019030506,0.007866924,0.038629033,-0.03489465,-0.017625133,-0.006833062,-0.08379358,0.06832375,-0.08208282,-0.017156508,-0.032734558,-0.020396749,0.061084233,-0.036846094,-0.035665944,0.0071817837,0.07331746,-2.3116335e-33,0.17692147,-0.037090093,0.0728729,-0.045631755,-0.06770024,0.09288839,0.025693683,-0.03847721,0.025794016,-0.034055326,0.037600756,0.035923347,-0.03760043,-0.015324681,0.009935679,-0.06327179,-0.01573465,0.004151158,-0.066297926,0.0021247598,-0.08403083,0.09574927,0.022134695,0.0005394864,0.06710373,-0.06862002,-0.0022623143,-0.008896854,-0.0083403215,0.024106178,0.065078504,0.027861841,-0.007081999,-0.013848012,-0.027485607,0.05241849,-0.083723664,-0.0056491643,0.003953923,0.055838823,0.019462999,-0.010926896,-0.010895012,0.073463075,0.026821477,0.060172915,-0.17485245,-0.028667204,0.04340576,-0.08197293,0.017084112,0.03676142,-0.014746444,-0.022924418,0.04488691,0.044128325,0.032793157,0.048017494,-0.027438251,0.049288232,0.022819413,-0.057010483,0.11752539,-0.015410836,0.007349317,0.06951515,-0.019466804,0.07476983,0.035854436,0.048606873,0.094994605,0.032303944,-0.025254097,0.0415988,0.011660204,-0.02994278,-0.078938685,0.033302955,-0.01977388,0.06998678,-0.01415818,0.0019947686,-0.05563786,-0.021772271,0.012267385,-0.063468866,0.0068142307,0.08192911,-0.029920133,0.029640932,-0.046881296,0.0065849815,-0.023595478,0.061120816,0.059375186,-4.063823e-08,-0.0014503634,0.010485383,0.064566135,-0.017154142,-0.012863663,0.088470586,-0.014158172,0.031004522,0.02453657,-0.0045161024,-0.06295725,0.12916808,0.012225675,0.09205148,0.05914592,0.036399443,-0.025633404,-0.05570677,0.012432787,0.0073444815,-0.04914019,-0.023231173,-0.14691891,0.042933077,0.039287087,-0.08405378,0.028091943,-0.02046495,0.041031625,0.0085670445,0.015364645,-0.001290359,-0.0071077957,-0.040768854,-0.06601343,0.040711254,-0.081672154,-0.009115152,-0.04449056,0.033944197,-0.05756376,-0.030594055,-0.03622434,-0.0020685035,-0.039708927,-0.0035289212,0.014442002,-0.010720582,-0.088298365,0.038888406,0.101670094,0.0054269796,-0.0019791985,-0.028994842,-0.053711478,0.11166348,0.04844975,-0.10520874,-0.03749885,0.017530356,0.0076498035,-0.03751466,0.06442598,-0.012926298 +1.1.1.288,"Requires a molybdenum cofactor for activity. NADP+ cannot replace NAD+ and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate [3]. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14 (abscisic-aldehyde oxidase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.14.137 [(+)-abscisic acid 8'-hydroxylase]. Abscisic acid is a sesquiterpenoid plant hormone that is involved in the control of a wide range of essential physiological processes, including seed development, germination and responses to stress [3].",384,1.0,-0.07357638,-0.061970558,-0.12835847,-0.00421054,0.12200478,0.047162313,-0.08383954,0.02476474,0.038871396,-0.036803376,0.11882742,-0.018264705,-0.036186744,-0.045396436,-0.07364452,0.05002681,-0.013482991,0.0016905231,-0.0031980786,0.013730367,0.027098818,0.043760993,0.01260772,0.006927764,0.070569344,0.008363062,-0.0959604,-0.006745843,0.027025875,-0.06947151,-0.027686566,0.04727594,0.06360982,-0.032046057,0.003100276,0.054528564,-0.0127651375,-0.022319244,0.0800411,-0.0013335131,0.00026796528,-0.017101936,-0.022475427,0.0060150665,-0.056219004,-0.022972183,0.021311313,-0.00663605,-0.0029508814,-0.022915533,0.03471588,-0.001535259,0.041734155,-0.0109113725,-0.041519895,-0.056100424,-3.895134e-05,0.08414928,-0.0041734115,0.019360054,-0.008298764,-0.037374742,0.048781183,0.042684346,0.0015666556,-0.0032736887,-0.061283674,-0.048702434,-0.0027490058,-0.034952622,-0.04413023,-0.057337176,0.0073453323,0.03044071,0.007481414,0.08462793,-0.03736745,-0.0050823987,0.024671953,0.010306786,0.03056404,0.057106525,-0.024721077,0.047577936,0.061521534,-0.06650579,0.005326473,0.040742792,-0.07062964,0.043989733,0.03853782,-0.005744525,0.010259079,0.025463784,-0.05388745,0.09309558,0.07924989,-0.09068861,-0.09197498,-0.057922054,-0.055432975,0.15489444,-0.06620983,-0.046051204,-0.06804325,-0.03880864,-0.063073926,0.025006743,-0.04102336,-0.003115038,-0.051765293,-0.05024124,-0.0054333885,-0.021961398,0.040524617,0.017504768,0.03776389,-0.002557277,-0.0046569486,-0.08530731,-0.03384351,-0.017164323,-0.023480339,0.034296624,-0.0070117135,0.013591647,-0.043252748,3.6192894e-33,0.10698061,0.047044855,-0.10876736,-0.017397104,0.039938327,-0.008578878,-0.057402402,0.03163568,-0.016901663,-0.05897971,-0.015217701,-0.089471035,0.008253738,-0.009245031,0.021436539,-0.010605091,-0.03345323,-0.08868309,0.06463708,-0.0012002168,-0.02514024,-0.0069946954,-0.078752115,0.006848193,0.03994895,0.043820277,-0.01736622,0.037793744,-0.054812986,-0.02365603,0.053796142,-0.037239537,-0.103584945,0.020666482,0.047917493,0.0006923611,0.013852269,-0.046787996,-0.030873151,0.059823085,-0.11088001,0.094750054,0.022888288,-0.07276986,0.09231136,-0.05859476,-0.025267363,0.07204785,0.09535957,0.040390186,0.0069414144,0.030621719,0.13072382,-0.05523933,-0.01488982,0.01940881,-0.055393085,0.005471405,-0.07144749,0.056602556,-0.009039693,-0.0064898008,-0.03040209,0.04765426,-0.04578402,0.035463776,-0.15313327,-0.10418904,0.050776184,0.08234396,-0.04772827,-0.045663524,0.054367706,-0.039968193,0.023056889,-0.0056870803,-0.0060426816,0.047346596,0.016262261,0.072783194,0.014092641,-0.017058767,0.053475782,-0.04377549,-0.013415816,0.01839971,-0.01170111,0.024240706,0.023696324,-0.014804727,0.06256196,-0.027873296,0.013573317,0.019821102,-0.014176927,-3.8869205e-33,0.12359169,-0.07716042,0.118501626,-0.07349516,-0.02277013,0.10587407,-0.037266076,-0.060305815,0.015115124,-0.042203933,0.029973427,0.058234207,0.016668258,-0.0020844992,0.04936617,-0.0064088707,-0.058864128,0.076029755,-0.022057822,0.004953647,0.0068951175,0.14940082,0.0170223,-0.0131477155,0.07403915,-0.038028717,-0.0074776364,0.04750937,-0.01011717,-0.0020165292,-0.00019024777,0.017015768,-0.08115525,-0.025938971,0.016409907,0.0233981,-0.09794797,0.015320126,-0.121655695,0.046529263,-0.009900367,0.074105054,-0.09033033,-0.004177677,0.09124278,0.034187037,-0.087628596,0.0011865455,0.042118177,-0.0014386356,0.01757827,0.025975704,-0.0052480367,0.059347358,0.09164375,-0.020098556,-0.055220682,0.04781973,-0.0057114204,-0.03241953,-0.0073645497,-0.009337814,0.003556963,-0.010208414,0.03120297,0.034713812,0.012626821,0.03552943,0.015695052,0.02540011,0.08775001,0.0135198,0.05368894,0.062570184,0.0064360593,-0.051575962,-0.066168904,-0.037257466,-0.04774572,0.023333801,-0.0021856355,0.047870606,-0.03244693,-0.028680433,-0.00942924,0.0057074064,-0.029906271,0.11675542,0.03300882,-0.013856654,-0.027717076,0.008141476,-0.010373213,0.023595544,0.068016626,-4.855962e-08,0.021748153,0.020300893,0.002822081,-0.07513252,0.04210345,-0.008560549,0.007284829,-0.08157758,0.0017618637,-0.032043945,-0.011913855,0.1089016,0.039507855,0.0027001572,0.023803603,-0.015408788,0.045630217,0.052841425,0.027357785,0.080670014,-0.05022086,-0.031745385,-0.11001415,0.078323215,0.058681313,-0.08833418,0.04121669,0.019728659,0.065464735,0.04644648,0.03796205,-0.0034740563,0.13175401,-0.019043854,-0.06852297,0.03593067,-0.008668981,-0.027326867,-0.08486482,0.027362734,-0.015489119,-0.08388718,0.0005062076,-0.009883175,-0.0141117405,0.013589045,0.020656189,0.025281182,-0.039872218,-0.030282857,0.04233887,-0.06486484,0.046196412,-0.058695216,-0.04926859,-0.0123504605,0.007915696,-0.064347714,-0.0028527007,-0.029574472,-0.018317545,0.02112631,0.15712896,-0.06346473 +1.1.2.2,"The enzyme from the bacterium Gluconobacter oxydans acts on polyols with a D-lyxo configuration, such as D-mannitol and D-sorbitol, with preference towards the 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+1.1.2.3,Identical with cytochrome b2; a flavohemoprotein 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+1.1.2.4,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.1.2.5,The enzyme from the sulfate-reducing bacterium Desulfovibrio vulgaris can also act on (R)-2-hydroxybutanoate.,384,0.99999994,-0.078640595,-0.06620357,-0.03656602,-0.08105574,0.023729874,0.051871896,-0.07861641,0.04311643,-0.0139087215,-0.019401599,-0.029340362,-0.027025236,0.038842052,0.07691088,-0.0166862,0.042311266,-0.042402346,0.049721763,-0.0039604376,-0.0046867738,0.10926376,0.017107585,-0.056257684,-0.0024505802,0.017710928,0.08062252,0.03437902,-0.0035702984,-0.072001465,-0.06338009,0.062775575,-0.012495173,-0.0006352829,-0.06363107,-0.0069005038,0.09673902,-0.045842733,-0.036819767,0.09417578,-0.022697298,0.003749355,0.045646116,0.0033527063,0.0069076195,-0.02355304,-0.06460392,0.014736668,0.07670924,0.07057173,-0.08974076,-0.09447251,-0.008440113,-0.025397673,0.05929489,0.06231862,-0.016133545,-0.009858179,-0.003308814,-0.019069202,-0.02394733,0.026998108,-0.006012244,0.052196573,-0.022536535,-0.01838317,-0.050443333,0.015404148,-0.010773487,0.06797854,0.0025920016,-0.14308834,-0.014788711,-0.0038930217,0.05612881,-0.028794093,0.009501657,-0.06051784,-0.009680814,0.05962162,-0.039941788,0.015474207,-0.03304962,0.022997051,0.10497899,-0.008354791,-0.052027453,0.048179917,-0.096710965,0.077249125,0.024616366,0.06191302,0.022993349,0.0062367404,-0.023718616,-0.08419594,-0.022038152,-0.031690814,0.07612851,-0.011691821,-0.0067851874,-0.033339497,-0.014360735,-0.045660358,-0.10701222,-0.044790216,-0.07786096,0.00023069118,0.11173817,-0.013925743,-0.012858861,-0.043689083,-0.0060803113,-0.04011378,0.042597458,-0.08225058,0.13080591,0.101049446,-0.08710632,-0.13048732,-0.09170243,0.006235936,0.0016927995,0.04660962,-0.0215387,-0.04823823,0.041390534,-0.119586185,-6.24546e-34,0.08905858,-0.012802799,0.045498144,-0.06551949,0.016643345,-0.020967752,-0.09369734,0.117759466,0.030396013,-0.03972944,-0.029419042,-0.0039948206,0.04386524,0.03326354,-0.059836842,-0.0016839554,0.026887344,-0.017651413,-0.0064642853,0.007141446,0.027632903,0.044651885,-0.021197923,-0.026994655,-0.02005163,-0.017987587,0.040189423,-0.0006830151,0.08685104,0.0098729,0.036989685,-0.14933361,-0.08426381,0.03159382,0.1036805,-0.036285046,-0.06655704,0.009983796,0.001843115,0.013931767,0.004818476,0.012410371,-0.0033939106,-0.06398915,0.04482131,-0.04844602,-0.016388465,0.121277876,0.028333021,0.081829704,0.089214064,-0.010021436,0.052214894,-0.017246889,-0.02179868,0.032781556,0.00036035,0.002527741,0.01762926,-0.004239191,-0.015218402,0.05835775,-0.025395973,-0.05713983,0.024525283,0.019466292,-0.0071101002,0.029678363,-0.017796041,0.052098602,-0.032229453,-0.031138638,0.047013942,0.089185074,0.011609444,0.0023992888,-0.012282347,-0.032647274,0.105409436,0.025647622,-0.060837984,-0.017269291,0.030955128,-0.03146214,-0.086986475,-0.0194787,-0.03619839,-0.03778446,-0.018460512,0.05317601,0.00020108574,-0.09133691,-0.10914208,0.021745985,0.02382926,-2.175186e-33,0.037398797,-0.03796739,-0.012926485,0.014588932,-0.004996363,0.047066092,0.08553267,0.015316761,0.04454934,0.009589494,0.052144106,0.052773,0.01457813,0.010976239,0.03263968,0.011647044,0.00804825,0.00973401,-0.0836466,0.005124224,0.053993735,0.08013198,0.06685562,0.04033655,0.0104954215,0.0053273365,0.14117573,0.06397688,0.047056705,0.065916345,0.020164551,0.025146348,-0.032223977,-0.03632343,-0.07162459,0.0495288,-0.03608713,-0.008735674,-0.036668677,-0.003667912,-0.0014812375,-0.041385233,-0.0015669862,0.12817253,0.02828594,-0.0011377481,-0.040529534,0.026035527,0.035307754,0.0044923266,0.008436454,-0.02242637,0.057312757,0.026652554,-0.014811241,0.0068704695,-0.026092948,0.01708465,-0.0088809,-0.0076440484,-0.03258861,-0.05838303,-0.05304535,-0.07058055,-0.030505234,0.0152075775,-0.0011976555,-0.0034177445,0.02609933,-0.07235742,0.07401798,-0.025374422,0.031899642,-0.024329174,-0.080346756,-0.027978932,-0.06374269,-0.03484769,-0.037393514,0.0059703584,0.026116516,0.08697855,-0.0008219888,-0.10241281,0.011687123,-0.06102934,-0.05529445,0.07577042,-0.024071513,0.06637194,-0.0625856,0.002681105,-0.10740974,0.061525308,0.06747639,-2.811507e-08,0.011705697,-0.023648113,0.11616956,0.032515675,-0.019280717,0.020844016,-0.015034181,0.0198974,0.026073007,-0.0044825235,-0.019327767,0.086001486,-0.021479787,0.011595633,-0.0015082199,-0.022555355,-0.0031590727,0.002696717,-0.064736284,0.0005558687,-0.028780527,-0.07850861,-0.09478533,0.043175373,0.052691404,-0.09835871,0.009954554,-0.050214984,-0.042595454,-0.03740023,0.053882986,0.061227545,-0.022347033,-0.010504834,-0.07980328,-0.0077525256,-0.029064024,-0.0125959795,-0.023477022,0.018453013,0.02186228,0.023770338,-0.060901932,0.055135872,0.036693353,0.032297112,-0.057013787,0.06180798,-0.03031574,0.013529769,0.08047276,-0.010031134,-0.02072938,-0.022433445,-0.109962456,0.08803916,-0.011465929,-0.05809443,-0.050785445,0.019047007,-0.0064953407,-0.060793683,0.16404748,-0.020325523 +1.1.3.3,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.1.3.4,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.1.3.5,"A copper glycoprotein. Also oxidizes D-galactose, D-mannose, maltose, lactose and cellobiose.",384,1.0,-0.02474256,-0.08305598,-0.0026563478,0.073049456,0.010275645,0.04040515,0.018512074,0.0089802435,0.006768938,-0.030090438,0.007777401,0.018937109,-0.07296681,-0.0020437413,-0.08632091,-0.056794673,0.03754086,0.07656859,-0.049224965,0.013309449,0.059808347,0.0026284966,0.014316396,0.0062585208,0.042765178,0.044671386,0.0018963431,-0.04124353,-0.03827418,-0.10979856,-0.035396352,-0.057768356,0.04985827,0.03353043,0.025038492,0.02319204,0.02525819,0.024438938,0.0028260748,-0.06727168,0.0352523,0.020436684,0.083960354,0.03952893,-0.03730885,-0.03016427,0.003489457,0.042554557,-0.013930325,0.07178032,-0.0056887134,-0.05930286,-0.021897074,0.06625326,0.10698832,0.031616963,-0.02920332,-0.06132933,0.040692843,-0.019166365,0.03377681,0.020763407,0.030355245,0.067645036,-0.016097138,-0.0773562,0.050479274,-0.011599902,-0.026346892,-0.04617812,-0.016641792,-0.060703192,-0.06921648,-0.012871742,-0.0066824183,0.10083437,0.09472923,-0.14442326,0.118270405,0.014483773,0.020751458,0.080848426,0.05407193,0.05016121,0.03982133,-0.02561068,0.05818636,-0.009372914,-0.09456566,-0.11037321,0.022179764,-0.015072951,0.008079336,-0.055302203,-0.020704525,-0.016999612,0.019947398,-0.038939584,-0.004127555,-0.04999066,-0.002002952,0.07065783,0.05629875,-0.08093964,-0.08986283,0.027000777,-0.08660999,0.079513416,0.05899702,0.011999601,0.018932693,0.031903423,-0.03560909,0.011193182,-0.037682816,0.027493713,0.008250825,-0.05822914,-0.018742986,-0.03150583,-0.02734697,0.0023521956,0.03703026,0.03799529,-0.009904421,0.017468125,-0.0021446866,-2.175997e-34,0.03589239,-0.0057540685,0.026839362,0.00077461044,0.0719693,0.00689721,-0.045765836,0.010706409,0.02433635,0.015513275,-0.09199922,0.0122628035,0.039304774,0.10028924,0.010774642,0.032875855,-0.013390784,-0.073485225,0.06589087,-0.058010448,-0.0046414933,0.095233746,-0.0072678663,-0.00410223,0.053871613,0.0012463928,-0.031993285,0.046429608,0.042741653,-0.008434954,0.04783098,-0.039969414,-0.014427234,0.046035606,0.032755174,0.018189466,-0.02968313,0.009737512,0.048553437,0.07185062,0.002394254,-0.012322812,-0.019334273,-0.011216797,0.017970663,-0.08580794,-0.07590925,0.06887603,-0.0027781012,0.04902503,0.059955854,-0.065369025,0.005850317,-0.010469951,-0.062073108,0.027118769,-0.1033107,-0.011537972,0.019227492,0.033633564,0.0085343,0.055371597,-0.06852083,0.0038326192,0.03918075,-0.00027815462,-0.024357045,-0.0032093138,-0.036690433,0.0037640037,-0.09359512,-0.033507988,0.06922387,-0.001841016,-0.024268363,-0.03526148,-0.047611285,-0.011030169,0.07107573,0.053939532,-0.03208811,-0.0031082944,-0.0043362207,0.011499372,-0.058954038,-0.06372426,-0.10395005,-0.029278088,-0.0047139907,0.0029273208,0.008824916,0.017726852,-0.0861209,0.011522949,-0.0352669,-2.66954e-33,0.10901957,-0.08559162,0.053480532,0.00219301,0.0033309942,-0.028417181,0.036830142,-0.02848411,0.043023143,-0.07016725,0.066058405,0.007983625,-0.016895104,-0.056553528,0.035055634,0.055495225,-0.069367364,0.09677626,-0.051149063,0.03312785,-0.035118043,0.04321039,-0.02488005,-0.035927143,0.08659466,-0.0076321373,-0.02709139,-0.04544789,0.07406587,0.032999568,0.036459118,0.050229188,-0.024554085,-0.07708287,-0.09381886,0.01970526,-0.05040941,-0.008946702,-0.021602293,0.013571804,0.023538351,0.09887919,0.05234802,0.092637666,0.097422,0.06874827,-0.06510085,-0.061080795,-0.032711223,0.056557573,0.005573909,0.0011021455,-0.030775178,0.05776831,0.06449591,0.07651029,0.022045398,-0.051950812,0.0069073155,0.01105911,-0.054752637,-0.011964671,0.03176318,-0.054179076,0.0090961745,0.04066229,-0.08063515,0.064075254,0.046394598,-0.019225266,0.07546807,0.022063054,-0.020295579,-0.05854957,-0.06535064,-0.05243343,-0.1278011,0.0067476104,0.013637712,0.03607047,0.04689707,0.048971877,-0.0078022694,0.009787971,0.028834151,-0.03805142,-0.0124251405,0.14656031,0.018931689,0.046812285,-0.10058879,-0.084738165,-0.012348677,0.078345165,0.06603086,-2.6877881e-08,0.0036372086,0.010259574,0.049123693,-0.100312814,-0.047216672,0.06835076,0.06810455,0.051978666,-0.021373942,-0.0440984,-0.02259458,0.14873464,-0.036559775,-0.08691012,-0.026427126,0.057265308,-0.029951008,-0.05618432,-0.0046760575,0.03154543,-0.10244566,-0.0022324685,-0.07015737,0.056097507,-0.07559668,-0.039180156,0.08194422,0.03625114,-0.10273329,0.023513623,0.013601338,0.07446562,-0.04469694,-0.071437754,-0.07774489,-0.04680331,0.010188141,-0.042463828,0.01793419,0.012212735,-0.019491954,-0.015450802,-0.044597406,-0.013800388,-0.0038536103,-0.06619653,-0.03974791,0.025271859,-0.021568576,0.015386248,-0.036039922,-0.015488673,-0.11718343,-0.054025773,-0.04322298,0.017849047,0.030447146,-0.039715253,-0.06978824,-0.035717797,-0.0062533105,-0.04143762,0.16471772,-0.022676472 +1.1.3.6,"Contains FAD. Cholesterol oxidases are secreted bacterial bifunctional enzymes that catalyse the first two steps in the degradation of cholesterol. The enzyme catalyses the oxidation of the 3beta-hydroxyl group to a keto group, and the isomerization of the double bond in the oxidized steroid ring system from the Delta5 position to Delta6 position (cf. EC 5.3.3.1, steroid Delta-isomerase).",384,0.99999994,-0.0610615,-0.06884477,-0.07716228,0.0049275537,0.010805183,-0.001430176,-0.06916355,-0.027871678,0.028538028,-0.036756236,0.026417494,0.027229464,-0.09796045,-0.06478298,0.016283501,0.023376983,-0.10998945,0.061197035,-0.014228886,-0.037464283,0.08797793,-0.034290276,-0.05036906,-0.007864917,-0.0072606835,0.05162674,0.09916707,-0.057848576,-0.07162296,-0.08581543,0.048108447,-0.0432603,0.0552867,-0.028301995,-0.027315471,0.043352995,0.033926822,-0.07139456,0.04931102,-0.011165731,0.04560722,-0.019614931,-0.0064467564,-0.037395697,0.008714125,-0.053467773,-0.01319968,0.019203965,-0.01882232,-0.024451762,-0.0077305613,-0.08034997,-0.051061817,0.01169837,0.01107674,0.043567736,-0.03336736,-0.054052535,-0.026024893,0.03093541,0.029627543,0.00553238,0.029644072,0.035502892,-0.028922545,-0.11426505,0.038654573,-0.050811376,0.0064831288,-0.030758737,-0.04232397,-0.08414227,-0.09520351,0.0012712035,0.020168852,0.05268071,-0.071143486,-0.10296851,0.02854093,-0.06326631,0.015660781,-0.068951294,0.043457143,0.16152352,0.08495962,-0.03762015,-0.012387123,-0.066743895,-0.023870315,0.02174994,0.009601555,0.0077459263,0.027059166,-0.002457277,-0.04574302,-0.0067494093,0.085659735,0.052087594,-0.03984865,0.0013107891,0.0025439914,0.05469356,-0.024583431,-0.0738028,-0.026072768,0.014640377,0.006988299,0.07698976,0.0030361132,0.010793416,-0.009008451,0.00849578,0.029997991,-0.053022414,-0.019813148,0.09573117,0.026345484,-0.06123568,-0.03242902,0.025380757,-0.024281323,0.03676322,0.007725984,0.0099866,-0.044722874,0.028087677,-0.010091272,2.7998279e-33,0.050419345,-0.0124411,-0.013310983,-0.027047358,-0.035715982,-0.015171807,-0.03173899,-0.032980196,0.086581856,0.0066822576,-0.021946626,-5.7249956e-05,0.03868929,0.026670698,0.027560806,-0.009210235,-0.0049003693,0.026053725,0.110412195,0.0009126645,0.007319905,0.076457195,-0.0013376597,-0.019909548,0.004292967,-0.007501264,-0.021944225,-0.00078435877,-0.020376118,0.050692894,0.002139052,-0.058130316,-0.06729084,-0.030924344,0.028195027,0.04717706,-0.035646614,-0.017170526,-0.056817118,0.09102427,0.0477813,-0.08069983,-0.045380075,-0.04740707,0.023489652,0.028799249,-0.03866732,0.0998129,0.08405391,0.06784568,0.005935347,-0.0565804,0.067629725,0.042794846,0.03028852,0.071966864,-0.0023915544,-0.016727794,0.03971856,0.023460452,0.025470518,0.10792452,-0.09431752,0.039219446,-0.06388736,0.018985482,-0.035389908,-0.0903701,-0.055927068,0.082477875,-0.06311201,0.047785573,0.02720294,0.00690605,0.028711835,0.04228286,-0.041413788,0.037020326,0.021913854,-0.055920523,-0.014556704,0.01368279,0.014220948,-0.05249448,0.0058568367,0.046083756,-0.041632243,-0.012724258,-0.028244069,0.053798,0.026877064,-0.01448847,-0.065230355,0.035827707,-0.008967893,-3.871409e-33,0.040400326,-0.10054045,0.059537847,-0.11244063,-0.011024471,0.0683049,-0.02306885,-0.027883526,0.06859526,-0.06895887,-0.064303994,0.017188286,0.014113602,-0.072124116,0.052990712,-0.008885983,-0.039328147,0.035505284,-0.028745838,-0.043212432,0.0062747514,0.10183099,0.0024472172,0.15523385,0.03531222,-7.6808565e-06,-0.0274296,0.008074866,0.1167411,0.07269769,0.0067513357,-0.035410836,0.005375746,-0.004392427,-0.08089634,0.061215136,-0.07491434,0.037128143,0.024134548,-0.019011827,-0.07651951,0.023649188,-0.008712038,0.003629015,0.05702398,0.041475605,-0.048245095,0.035199624,0.021684278,-0.075963624,0.020533314,0.0065094647,-0.020484494,0.014536506,0.042481948,0.07226521,-0.0034884831,-0.0020802373,0.07450122,-0.08856903,-0.073193826,-0.047051325,0.08081127,0.018931184,0.011958949,0.047379237,0.03585414,-0.008387491,-0.01138022,0.028752962,0.014665336,0.05996093,-0.048395555,0.058058765,0.05113111,-0.06663785,-0.12055004,-0.025546098,-0.027995564,-0.004056229,0.011019888,-0.031107014,0.009783507,-0.07167598,-0.051438797,-0.06941348,-0.009827335,0.06840001,0.06012496,-0.009123225,-0.00815847,-0.0097795725,-0.08800937,0.033377193,0.057225216,-4.3307494e-08,0.060609225,-0.030592492,0.07246636,0.023728995,-0.038894914,0.059095822,0.007922127,0.040910617,0.124473706,-0.0643454,0.015434534,0.2138099,0.0163347,-0.04067604,0.019568214,0.025171697,-0.030372528,0.026096249,-0.0027858075,-0.006162361,-0.018787552,-0.009951098,-0.02317912,0.016421715,0.03976644,-0.030326929,0.024511088,4.7465586e-05,-0.018989954,0.006609506,0.05759337,0.012240673,0.032105073,0.042812563,-0.034598213,0.032077078,0.03314841,-0.018233811,-0.008081621,0.09360038,-0.07126348,-0.038486883,-0.09081146,-0.0019796053,-0.027277516,0.008161481,0.029168421,0.049972784,-0.055616144,-0.05276469,-0.044505928,-0.022980455,-0.058081523,-0.012640407,-0.11030378,0.00056912465,-0.032310728,-0.06830507,-0.05261359,-0.035015333,0.025932493,0.07692276,0.22994521,0.04614029 +1.1.3.7,Oxidizes many primary alcohols containing an aromatic ring; best substrates are (2-naphthyl)methanol and 3-methoxybenzyl alcohol.,384,0.99999994,0.009262452,-0.05950811,-0.06446152,-0.035568267,0.08272792,0.03806121,-0.040669072,0.0029730715,0.10153032,-0.09206307,-0.029175567,0.0096486015,-0.0886767,0.05813011,-0.025318261,0.11629434,0.006711502,0.06964046,0.08072325,0.0062664174,-0.0090414295,-0.009075826,0.06659916,-0.003234266,0.014276702,0.04546164,0.022323526,0.070534445,0.0039160606,-0.08023103,0.058875307,0.09839522,0.020327639,-0.051793564,0.0013829902,-0.0046560415,-0.06183911,-0.048347466,0.03000619,0.0038045715,0.014329104,0.017281255,0.024605714,-0.036058016,-0.03800568,-0.016335329,-0.030454254,0.036252238,0.021878194,-0.073223025,0.050940443,0.051829185,-0.0069420272,0.10863335,0.09226745,0.009356379,-0.020262374,0.025591018,-0.05181871,0.077788144,0.009852925,0.050066236,-0.015644984,-0.0052183014,-0.036253296,0.0003538203,0.012302635,0.0158199,-0.0039833095,0.0012942263,-0.09697389,-0.06802429,-0.026226444,-0.03453247,0.0048849774,-0.039924413,0.015776312,-0.051466063,-0.0012559636,-0.038017433,-0.046500295,0.023621986,0.03984109,0.08688663,0.10489913,-0.00793625,-0.127165,-0.07472228,-0.036821634,0.041986644,-0.06578107,0.03652404,0.007231115,-0.024539271,0.0007913583,0.03727499,0.07045093,0.03266114,-0.009061931,0.042611785,0.019317389,0.05322876,-0.077605926,-0.1005735,-0.07491806,-0.008191514,0.054145996,0.036155775,-0.021742158,0.012142768,0.03435524,0.03549951,0.03173172,-0.07103028,-0.05400824,0.082249604,0.056598816,0.012205222,-0.029143322,-0.016207332,-0.0848183,-0.0040653907,0.05046613,0.0011831953,-0.07746265,0.036158808,0.03907952,1.102938e-33,0.06600575,-0.0035542408,-0.031831276,0.023396831,-0.07314935,-0.07380948,-0.03039054,-0.025892487,0.07967972,-0.08800486,0.012420838,0.013360705,-0.033610754,0.01626316,0.08774351,-0.0720223,0.01915463,0.035798613,0.053779513,-0.019207157,-0.01706175,0.01134905,-0.048314955,-0.0018340355,0.020797228,0.0014731371,0.022746416,0.0071449857,-0.044974893,0.019233266,0.0025331117,0.078947276,-0.03014507,0.04267233,-0.08247636,0.08038501,-0.10958792,0.005109982,0.012461161,0.008183822,0.017363109,0.056813255,0.078417934,0.0036089453,-0.001344002,0.057145733,-0.05849936,0.15112148,0.023777306,0.06820492,0.008610234,-0.065495305,0.07539943,-0.006652462,-0.0585778,0.041346572,-0.026275842,-0.10451272,0.07749332,0.009751209,-0.1061932,-0.005963093,-0.11568898,0.03162737,0.012166647,-0.0054578944,-0.032371305,-0.053833336,-0.05981952,0.00791101,-0.033992197,0.09006688,0.061971948,0.030878797,-0.013917489,0.011715579,-0.011037094,-0.013418158,0.097465076,0.056169324,0.005547175,0.0008168915,-0.029456928,-0.074687794,-0.05922709,-0.034907833,0.015434892,-0.0109216,0.015231176,0.049942464,0.007266939,-0.07874404,0.037327573,0.009483697,0.027072301,-2.2782996e-33,0.11167481,-0.07093815,0.039038263,-0.06577064,-0.035351474,-0.034255274,0.033490095,-0.046801273,-0.0056419284,0.0063137533,-0.0015964725,0.0067412504,-0.018152587,-0.027872302,0.012922466,-0.056312338,-0.008600427,0.06186684,0.03661849,-0.064468496,0.07173572,0.07921715,-0.037863262,-0.0022759768,0.016436476,-0.037687656,-0.09547865,-0.041721143,0.0004502852,0.034197938,0.0147273885,-0.019402908,0.056638584,0.026427506,0.037601646,0.106933124,-0.06602858,-0.004675333,-0.08280451,-0.002712656,0.027612014,0.06597476,-0.051075667,0.020496676,0.0408159,0.022690095,-0.1729177,-0.07918516,0.040850382,-0.05386301,-0.01937436,-0.013883009,-0.07875238,-0.055628683,0.046821304,0.059729375,-0.01840722,-0.054338247,0.016748615,-0.02539704,-0.06544469,0.05475575,-0.015676111,-0.020558476,-0.04226417,0.0011495232,-0.011779423,0.044772938,-0.00529074,0.024178825,0.028302394,0.0322419,0.0502013,-0.0038540564,-0.08446645,-0.12759359,-0.053759407,0.020422522,-0.030355034,0.03236651,0.096800454,-0.0057106465,-0.023951456,-0.010307785,-0.0300472,-0.051075216,0.10314981,-0.020502113,-0.023199113,0.015100781,0.020532746,0.038918212,-0.030611437,0.07751056,-0.0144792795,-3.2037132e-08,-0.024660103,0.0011535757,0.12307073,0.03779898,-0.05246779,-0.0065276693,0.07607545,0.08656809,-0.00097251625,-0.08535047,-0.0072334893,0.08140464,0.040448718,-0.041407388,0.088986784,-0.010257996,-0.04966628,-0.054178737,-0.035652027,-0.049132857,0.02328888,0.042704254,0.046773057,-0.007112379,-0.0231769,-0.0528305,0.025155624,-0.027250564,0.020285603,-0.0010102568,-0.005067951,0.023919048,-0.059858978,0.023424404,-0.045228925,-0.005793427,-0.048310436,-0.07197859,-0.03818099,0.06363581,-0.04365094,-0.10093543,-0.06777749,-0.0025480683,0.076140665,-0.027447432,-0.040062226,0.009248937,-0.040502395,0.029083297,0.043853134,0.007892967,-0.00076106837,-0.014837243,-0.071783006,0.032668445,-0.0112928795,0.055992763,-0.025316158,-0.08973111,0.03976339,0.07396301,0.12021259,0.0649223 +1.1.3.8,"A microsomal flavoprotein (FAD). The product spontaneously isomerizes to L-ascorbate. While most higher animals can synthesize asborbic acid, primates and guinea pigs cannot [3].",384,1.0,-0.06391446,-0.08287875,-0.114483126,0.04959937,0.077876925,0.054041088,-0.024325557,0.04462394,0.024470408,0.008927749,0.032198742,0.026365474,-0.090385176,-0.024771128,-0.06974134,0.015354393,-0.0025972952,0.0037975514,-0.09446447,-0.01868856,-0.0064149513,0.016257579,0.08615427,-0.040324274,0.038903862,-0.06974523,-0.02276431,-0.089985386,0.0064200596,-0.06995831,0.110705286,0.021983199,0.08077689,-0.030322187,-0.0503901,0.004110158,0.04352975,-0.028105611,0.07104582,0.042032488,0.03814716,-0.06680889,0.017659895,-0.007924544,0.04751073,-0.009852838,-0.01477844,0.027508827,0.006734525,0.021188008,-0.02493405,0.018813448,-0.13492273,0.012113876,-0.13438264,0.029562019,-0.052303392,-0.020372918,-0.015191052,0.04457296,-0.01486371,0.018033637,0.069615275,0.009808489,0.046048407,-0.030968366,-0.07075348,-0.030351086,0.0511647,0.0077344947,0.052590728,-0.039768547,-0.0458244,0.06339004,0.041116353,0.093545415,-0.06870071,-0.007475605,0.046375938,-0.026849892,0.048339628,-0.03325114,0.06347069,0.043986436,0.026399009,-0.049618244,-0.054192644,0.076849245,-0.097584315,0.06101717,-0.033160795,0.03830479,0.004302774,0.018490732,-0.07044703,0.026785148,0.09373851,-0.01947584,-0.030598529,-0.010813607,-0.079556294,0.006682764,0.014796712,0.003238324,-0.005292803,-0.08176625,-0.10192059,0.00551709,0.032512933,-0.057374734,-0.016385017,-0.037373215,-0.013010704,-0.037535917,0.055877008,0.009376689,-0.024219515,-0.08701619,-0.016772693,-0.046555396,-0.006089557,0.10314486,0.015985545,0.11300158,0.0068896483,0.02254145,-0.025543544,1.781342e-33,0.06233996,0.0015571646,-0.0049723103,-0.007333816,-0.0058747274,0.047312155,-0.05531108,0.00022026943,0.038175385,-0.013545464,-0.044725783,-0.011122005,0.028051553,0.005076831,0.042395297,-0.014416902,-0.013251506,-0.08627467,0.095392816,-0.10517578,0.001205881,0.09101449,-0.02773525,0.043189887,-0.0048371432,-0.06762178,-0.059525967,0.044887066,0.04829217,0.01654452,-0.043145802,-0.052080054,-0.08670659,-0.0410402,-0.042645425,0.0026828144,-0.07101553,-0.11639965,-0.051876854,0.042051047,0.054163437,-0.027646694,-0.041131098,-0.00884392,0.0011107664,0.027993226,-0.043689243,0.03904268,-0.039567534,-0.005753071,0.011390019,0.015370106,0.113103725,0.09730379,-0.028749805,0.0012213147,-0.055885088,-0.011152716,-0.01962296,0.0695495,0.09619293,0.015963746,-0.022315664,0.10307296,-0.09145166,-0.013394363,0.00089637487,-0.02511679,-0.03220956,0.061727893,0.04400269,-0.063522995,0.0592117,-0.070745364,0.004278598,-0.014340636,-0.013104675,0.026079169,-0.034030106,-0.037602425,-0.031040495,0.047569174,-0.08071233,0.017803406,-0.017853925,0.061255652,0.04258455,-0.03127557,0.028806096,-0.045263503,-5.311983e-05,-0.07388004,0.022010507,-0.027599169,0.08673269,-2.4342317e-33,0.015747529,-0.11306872,0.030661605,0.04924205,0.015488286,0.045862924,0.08592527,-0.043856464,-0.02583492,-0.027274298,-0.0025489405,-0.060877196,0.021849439,-0.024499567,0.040586796,-0.004243377,-0.014163367,0.07677237,0.056647725,0.026116734,-0.06562161,0.021581309,0.03209752,0.13396323,0.048887204,-0.012067696,-0.018847184,-0.051754553,0.00440215,0.07169468,0.020590402,0.0784512,-0.08190567,-0.05720924,-0.02140395,0.018955719,-0.013269464,-0.01840975,-0.08124321,-0.040255614,0.00024828422,0.0545585,-0.041044228,0.030789778,0.10281783,0.07758349,-0.05665585,0.04661294,0.013006959,-0.0077258795,0.0023962185,0.0047097765,-0.013888352,-0.033741295,0.0011780335,0.04432705,0.07085559,0.013565248,0.035062492,-0.03613144,-0.00821312,-0.109827146,-0.0003271855,-0.07687006,0.08731586,0.031918824,0.03572296,0.1184008,-0.0023801553,0.021920558,0.14760111,0.04643046,0.0051450124,0.09739063,0.035902172,0.009959121,0.01126608,0.03734747,-0.007188074,0.0063177943,-0.049461704,-0.020897696,0.029766586,0.05727548,-0.08227382,-0.12796009,-0.010686402,0.08749005,-0.019811753,0.080937564,-0.04053627,-0.029106816,-0.046418674,0.021976892,0.07177065,-2.9156109e-08,0.027323255,0.010857013,0.024748363,-0.010594853,0.07293908,0.047867164,-0.032513622,-0.056942765,0.026339207,-0.037043877,-0.09051995,0.054247115,0.017292986,0.04944887,0.0021054721,0.0013149881,0.0030662064,0.079723425,0.037050106,0.011118251,-0.07593119,0.06181856,-0.054999877,-0.0036461265,-0.046928868,-0.04559955,-0.0022628491,0.040278997,0.07565626,-0.03571359,0.037259415,0.0033401423,0.06662886,-0.037615303,-0.049780354,-0.022479637,0.04895105,-0.046013534,-0.0026968673,0.031001553,-0.10626925,-0.0064416626,0.00413404,-0.012466339,-0.020614572,-0.04196361,0.058636,-0.014422452,-0.06648414,0.014495676,-0.030455459,0.016720131,0.00639104,-0.029006038,-0.03209436,-0.04470408,-0.081700034,-0.057311784,-0.010186382,-0.08096183,-0.0068669957,0.024770752,0.11357067,-0.022005092 +1.1.3.9,A copper protein.,384,1.0,-0.09597926,-0.045308277,-0.0067501324,0.07358289,0.017337816,-0.019804485,0.10939954,0.06327722,0.00664731,-0.05523374,0.045456022,-0.050407697,-0.028891444,0.010574607,-0.10932879,-0.06598482,0.036792316,-0.016828293,-0.032111295,-0.032520548,-0.022477653,0.050223473,0.020206846,-0.0071440474,-0.074925326,0.082031034,-0.005841709,-0.027055336,-0.0073671313,-0.07113261,-0.0066492176,-0.014930333,-0.043636434,0.016359182,0.031880736,-0.009539286,-0.030459248,-0.007549861,-0.008547945,-0.042447153,0.109836645,0.0041008326,0.12079722,-0.0031422162,0.02390941,-0.012181984,0.056055516,0.058037624,0.06373647,0.025602458,0.016492296,-0.063681744,-0.0294151,0.044125564,0.04935886,0.0062776306,-0.05329763,-0.06994775,-0.033792347,-0.04383334,0.026661318,-0.0063686487,-0.02113473,0.058485877,0.104287334,-0.051313017,-0.017551335,-0.0018613932,0.06300922,0.0031519113,0.0101941805,0.019358622,-0.05970557,0.05728974,0.00020798774,0.078062646,0.13937467,-0.09343502,0.09195695,0.016937459,-0.026881129,0.08247389,0.017630488,0.033593237,0.08734133,0.02510645,0.06339804,-0.0016646793,-0.12933305,-0.09640953,0.056552872,0.05432456,-0.033757165,-0.012513978,-0.046784036,0.018985048,-0.023535376,-0.057667077,-0.07270608,0.06806697,0.034213647,0.068777286,0.054774985,-0.09243402,-0.04048658,-0.024878997,-0.07295677,0.093901955,0.027646406,0.037723932,-0.006606063,-0.015675077,-0.014944817,-0.0056965686,0.04142041,0.021382703,-0.008312558,-0.016257018,-0.066541456,0.003850224,-0.050509207,-0.017057715,-0.033181172,0.014049778,-0.038779616,-0.040906306,-0.05762151,-5.4330353e-33,-0.015404258,-0.0209357,0.03708634,-0.0010540735,0.06585914,0.033504162,-0.06076692,0.016298497,-0.0035335158,0.007978118,-0.03897942,-0.01668606,0.027155366,0.039466243,-0.007020412,-0.063858084,-0.022648478,0.043150533,0.067616776,-0.0545251,-0.047697555,0.1073415,0.055338595,-0.0010377754,0.05672899,-0.058071338,-0.07352631,-0.06831533,-0.015118443,-0.014707181,-0.019780912,0.0105701,0.0052408143,-0.008986943,0.037298046,-0.04859189,0.05934128,-0.074637964,0.032392327,0.073130526,0.029526828,-0.01215347,-0.0110714575,0.044050977,0.021923402,-0.06559528,-0.049259324,0.08575771,-0.09181762,-0.043183196,0.085432015,-0.04115494,0.0927086,-0.030627333,-0.07245031,-0.026979053,-0.0564811,0.025466513,0.050621223,-0.0059851464,0.010798725,0.044637207,-0.1032989,0.054870352,-0.060513854,-0.019520983,-0.030665474,-0.012898294,0.034048226,0.061398346,-0.071260184,-0.026198052,0.050521526,-0.07110847,0.024081782,0.008271127,-0.091383144,-0.022506826,0.050823808,0.09545595,-0.053208545,-0.011762221,0.0003670748,0.01687922,-0.049838636,-0.018843727,-0.02751361,-0.004411817,0.08355185,-0.02564631,0.047385335,-0.001917761,-0.059557214,-0.0412748,-0.022370413,3.354556e-33,0.012029543,-0.047427673,-0.018599011,0.07455195,0.0439148,-0.05798611,0.027577814,0.013002341,0.042086843,-0.04151416,0.1384159,-0.041173466,0.06567916,-0.05153014,0.091836944,0.09492204,-0.10814992,0.12310629,0.03555109,0.04278384,-0.10522444,-0.006895259,-0.005916549,0.020681133,-0.02469764,0.06611035,-0.047617566,-0.058371354,0.025884077,0.030417645,-0.051836304,0.01804767,-0.038102806,-0.026877336,-0.113314666,0.024655255,0.07844346,-0.06393069,-0.0119805215,0.026000457,0.08183057,0.045057714,0.020898463,0.14186092,0.031635527,0.017497033,0.002430895,-0.03672251,-0.10572102,0.06762488,0.065223016,-0.00914299,0.030302843,0.025455857,-0.02236232,0.022399021,-0.023392541,-0.015376859,-0.0104430895,0.085349604,-0.008705253,-0.026491186,-0.025311172,0.04565102,-0.00032050005,0.011674379,-0.019274252,0.06871322,-0.009318933,-0.03683091,0.11735781,0.08319018,0.035162356,-0.040757395,0.02802436,0.0014792026,-0.011520053,0.025442634,0.024631258,0.04686897,-0.112943225,0.0036963166,0.019346906,-0.03153913,0.028312633,0.016827438,0.0004337707,0.08975211,-0.010459128,-0.0035366425,-0.05672644,-0.09883905,-0.029308286,0.0844893,0.054507554,-1.1418243e-08,0.0074742385,-0.009210173,0.013311909,-0.07801128,-0.007540657,0.10272917,0.07610568,-0.02139471,-0.01813874,0.026213026,-0.014255175,0.034689605,-0.048472848,-0.03139368,-0.0045238803,0.074973084,-0.031969145,-0.051561765,-0.013633069,-0.04342349,-0.019626932,0.037562273,0.046275303,0.022805255,-0.07014956,-0.035795946,0.005215055,0.08773117,-0.13343215,0.019085696,-0.021229642,0.00805145,-0.059237957,0.0018876991,-0.0028074414,-0.0060101333,0.050217364,-0.0011033843,0.0068932334,-0.008573096,-0.07642666,-0.00043103873,-0.06219991,-0.04973786,0.021553135,-0.053547338,-0.028717848,0.07519697,0.004360413,-0.034172334,0.009809595,0.0067805494,0.007063409,-0.029176096,0.0001055951,-0.02340847,-0.009628578,-0.04703639,-0.09595855,-0.013247383,0.0004524292,-0.050470788,0.09833216,0.008691365 +1.1.3.10,"A flavoprotein (FAD). Also oxidizes D-xylose, L-sorbose and D-glucono-1,5-lactone, which have the same ring conformation and configuration at C-2, C-3 and C-4.",384,1.0,-0.045083232,-0.11276959,-0.103233285,0.007818074,0.109842256,0.024920823,-0.026796527,0.056577273,0.053398695,-0.062801205,0.011610656,0.08121723,-0.10023031,-0.007841679,-0.05917412,0.041124515,-0.042966615,0.05587632,-0.09278427,0.012088172,0.0038979072,-0.014847918,0.05896728,-0.012444169,0.03283955,-0.015718747,0.00029949838,-0.050174594,-0.028793406,-0.04127647,0.07428594,0.069591835,0.027887676,0.02375616,-0.082013935,-0.00075630745,0.071830586,-0.013410245,0.0012729914,-0.0028608926,0.018292146,0.0017195032,0.07131841,0.0024821742,0.049327426,0.009300935,-0.07763924,0.07807193,-0.023309855,0.06639091,0.034584068,-0.032886893,-0.12369654,0.045917194,0.015081285,0.085939445,-0.04276399,-0.0487631,-1.4107351e-05,0.018713918,0.011723652,0.00040461455,0.06762355,0.04109348,0.010783437,-0.08304881,0.009319941,-0.02676646,0.048041128,-0.037076015,0.0006086629,-0.040860657,-0.053907096,0.0074018613,0.04055831,0.0908906,-0.049869508,-0.061019514,0.058923475,-0.0297859,0.08548717,-0.0071506337,0.1360898,0.119461596,0.0470209,-0.058039367,-0.00798403,-0.030671852,-0.06310664,0.040028714,0.009000038,0.028361531,-0.03567174,0.015015062,-0.07410519,0.043605763,0.090656765,-0.043311857,-0.085147135,-0.019824384,-0.053104363,-0.0043196925,0.046296492,-0.020690942,-0.030763097,-0.061405797,-0.04598019,0.06077994,-0.028955836,-0.06561556,0.0036359457,-0.031598613,0.011580511,-0.081785336,-0.02275058,0.003192884,-0.0042178426,-0.04089164,-0.02019255,-0.024992783,-0.049390897,0.08604331,0.024541257,0.07655413,0.022845667,-0.016032828,-0.07599221,-1.2798187e-34,0.08623031,0.01025657,-0.019676032,-0.0013047436,0.0024888013,-0.026747717,-0.05429091,-0.012016722,0.054311745,0.005741728,-0.047121275,0.0048571457,0.024187777,-0.0024129415,0.07332165,0.004651511,-0.013277369,-0.057275623,0.053477164,-0.11706233,0.02576573,0.08232855,-0.019986734,0.047710862,0.065341,-0.015903307,-0.040469587,0.040671926,0.011687165,0.030011348,-0.014130512,-0.032895695,-0.054789193,0.041881397,-0.028204653,0.07917151,-0.10764535,-0.07604189,-0.0792545,0.068057135,0.01767285,-0.052026268,-0.047952037,-0.025509678,0.031491335,-0.034816,-0.075393975,0.093054615,0.0014988845,0.08890269,0.036730114,-0.04760819,0.067611605,0.13120912,-0.05510532,0.0066895974,-0.040939398,-0.022235498,0.04156598,-0.015843969,0.006209898,0.011486273,-0.0457526,0.06253861,-0.01328563,0.003541632,-0.043664414,-0.07468241,-0.035585262,0.0721804,0.016191166,-0.022907494,0.0692202,0.02234101,0.04599012,0.007277243,-0.056517035,-0.018468056,-0.010400212,0.020295983,-0.0048442925,-0.0039493786,-0.04008845,-0.009350291,-0.049379434,0.01818482,-0.0014228751,-0.03137392,0.017939381,-0.01529138,0.01390473,-0.05645285,0.038276464,-0.0068559498,0.052549735,3.9977782e-35,0.03425233,-0.108844504,0.032959726,0.068668865,0.03029744,0.0034356827,0.050767496,-0.06753189,0.027113834,-0.063978344,0.03358477,-0.06737803,-0.0750804,-0.0049342457,0.0581715,0.0313307,-0.056896538,0.018675977,0.04469096,0.036460448,-0.023956742,0.0010381138,0.026325306,0.091820374,0.05057567,-0.020808365,-0.0025336924,-0.11517377,0.033658355,0.04852232,-0.033229712,0.022297576,-0.006830984,0.0048910747,-0.05742747,0.025507897,-0.03404378,0.029711263,-0.030116301,0.04346015,-0.040452868,0.02994345,0.03200583,0.060227796,0.092251584,0.0529437,-0.036642894,0.030139884,0.08251374,-0.036430098,0.00720144,0.0013501759,0.016656838,0.036707077,0.072480805,0.071767494,0.09320301,0.021475755,-0.033365816,0.02783413,-0.0145283425,-0.09480699,0.035598136,-0.028592527,0.07791831,0.06991903,0.021648273,0.122222945,-0.00047890202,0.008260414,0.097491674,-0.02785036,0.046521097,0.06950731,0.028645612,-0.09028269,-0.028667443,0.06311126,-0.01362896,0.037239302,0.052317154,-0.0024388193,0.008360692,0.050347414,-0.07563933,-0.09972439,0.009666959,0.07367616,0.025595732,0.030379038,-0.047054894,0.042764354,0.0021630253,-0.019933445,0.09264074,-3.4327698e-08,0.005153956,-0.03235105,0.010154334,-0.022062663,0.0652324,0.011963606,-0.015924823,-0.01759889,-0.0072497674,-0.05776231,-0.04434546,0.16984662,-0.041895244,-0.05095806,0.04243563,-0.07975539,-0.008533942,0.00075771386,-0.035195272,-0.018703572,-0.091740094,0.042023566,-0.074352086,-0.024056911,-0.055847757,-0.041554913,0.022785898,-0.027120104,0.0544766,0.03660989,0.023268873,0.03393588,0.028948171,-0.06668412,-0.117000915,0.012171618,0.02584105,-0.07755807,-0.01960137,0.049182743,-0.07667601,-0.025582368,0.0139907645,-0.01777839,0.01820094,-0.07174098,0.06277757,-0.00962331,-0.07345185,-0.018076893,-0.039717615,-0.003465697,-0.050019123,-0.022154279,-0.06683339,-0.0007173613,-0.02114454,-0.023133878,0.009470534,-0.10993754,-0.059782024,0.026341202,0.12406216,-0.0054364935 +1.1.3.11,"Also acts on D-glucose, D-galactose and D-xylose, but not on D-fructose. 2,6-Dichloroindophenol can act as acceptor.",384,0.99999994,-0.046893094,-0.11501744,-0.012125569,-0.008026644,0.079140656,-0.0053510717,0.05211049,0.00513565,0.06328532,0.01633903,0.0049387286,0.021305822,-0.13330296,0.0614979,0.032500654,0.060876414,-0.04429004,0.06766061,-0.06467272,0.057407793,0.08788569,-0.033684105,0.022236807,-0.039095104,0.028711203,-0.025227144,0.050993092,-0.013565788,-0.022167314,-0.06398469,-0.030552017,0.014752185,2.301334e-05,0.06496098,0.001590628,0.057988625,0.021133518,-0.024140146,-0.013043371,-0.04000628,-0.007210912,-0.034449264,0.03510244,0.010076095,-0.053398896,-0.06992627,-0.112867735,0.08120509,-0.010552191,-0.051490087,0.017812872,0.0069905845,-0.010076078,0.09752014,0.019603724,0.13968155,-0.032890845,-0.00661434,-0.032653965,-0.041019868,-0.040248707,0.0010028912,0.015280257,0.018818675,-0.029513523,-0.035544306,-0.016643925,-0.020531563,-0.01015603,-0.06389478,-0.015657539,-0.042153295,0.008184927,-0.05071517,0.083728984,0.018994557,-0.011861168,0.0050379704,0.038315713,-0.07116866,0.017113902,-0.029131783,0.09223057,0.022836188,0.031059578,-0.0685583,-0.029051054,0.021854548,-0.036543325,0.060342357,-0.00645503,-0.04781767,-0.010894876,-0.035067227,-0.076980606,-0.013284503,0.050286196,-0.034247678,0.027306885,-0.01134531,-0.017985981,0.007742074,-0.053865083,-0.037107427,-0.07258433,0.034159042,-0.044764366,0.014897095,-0.05430391,-0.052974466,0.012476148,-0.05907069,0.12091635,0.093400374,-0.09558497,-0.0052481126,0.004018575,-0.11288938,0.010622532,-0.09247266,-0.033689816,0.007155873,0.06944505,0.026809186,-0.047435973,0.095659874,0.027927348,1.9578619e-33,0.019398736,-0.04646911,-0.00097613124,-0.043820217,-0.0092396,0.04954085,-0.061111055,0.06132874,-0.00052717805,-0.05904005,-0.07679174,-0.04796612,0.03697613,0.05341457,0.010125595,0.025178712,0.03327429,0.0067585087,0.047617115,-0.0045082932,0.043553278,0.06928989,-0.08744544,-0.03180563,-0.019705387,0.055534925,-0.067598,0.06923559,0.065527804,0.0056287297,0.012757511,-0.076431,0.076832175,0.12257559,0.0090593565,0.11668795,-0.0461633,0.02572375,-0.024831321,-0.05630477,0.021951176,-0.0151747735,-0.0751798,-0.038019456,-0.0060600294,0.006120473,0.023018653,-0.0536853,-0.001240417,0.09984807,-0.01830621,-0.03313796,-0.00012437475,-0.009333646,0.00030525718,0.017434165,-0.017285345,0.010023789,0.02377136,0.0097878715,-0.054942857,0.08830214,-0.024929283,-0.033328414,0.01576857,0.023251148,-0.04147148,-0.037877217,-0.117291845,0.050310872,-0.085375175,-0.018641884,0.037747644,0.04971793,0.08592722,-0.059667446,-0.020651024,0.010440172,-0.0028466785,-0.011643225,0.011583409,-0.05782858,0.026528241,-0.016996788,-0.10871454,0.06211144,-0.05675587,-0.12428985,0.008194647,0.020220425,7.243496e-05,-0.04505426,-0.06686688,0.033741307,0.07490572,-3.8143238e-33,-0.01587094,-0.053110946,0.07354853,0.06065267,0.034390584,0.085687876,-0.011384803,-0.1143675,0.10574725,-0.07787905,0.07365718,0.026702449,-0.060465347,-0.0059489748,-0.010059897,0.017392114,-0.029826581,0.09488164,-0.05453525,0.03068858,-0.022594506,0.06279115,-0.04208818,0.06715175,0.063478224,0.02769726,0.047951173,-0.032321483,0.08370639,-0.01570738,0.04670379,0.057351775,0.004024763,-0.030993374,0.012659868,-0.03145075,-0.1088292,0.0022518565,-0.10087386,0.077322245,-0.028985107,0.01876962,-0.009429366,0.04297434,0.051315807,0.02214374,-0.014231957,-0.053044066,0.014072856,-0.0054582846,-0.027517663,0.019828757,-0.01705106,0.03915229,0.062039338,0.089342326,0.105747186,-0.059064135,-0.026732069,-0.024576033,-0.016816434,-0.05746657,0.067399584,-0.067988366,0.06246434,-0.05511184,-0.045429267,0.15273666,0.060500428,-0.0078282915,0.07450871,-0.04481549,0.018227117,0.03703052,-0.014237198,-0.08072199,-0.0571247,-0.03057527,0.034130722,0.011250792,-0.043746974,0.06947261,-0.0012086121,-0.020669539,-0.006984623,-0.094292134,-0.034577597,-0.010703152,-0.057603423,0.063125566,-0.047134593,0.040374815,0.027038032,0.015411084,0.115334354,-3.2165175e-08,0.034852363,-0.056007657,-0.002117225,-0.00898182,-0.027336162,-0.022149255,0.055376485,0.02298794,-0.041640468,0.015482507,-0.05285009,0.15237686,0.028125452,-0.042667534,0.026784994,-0.014789145,-0.00713945,-0.033514082,-0.047061916,0.047029987,-0.056363232,-0.018776977,-0.09801205,-0.036427993,-0.009446565,-0.07505863,0.041388523,0.013724356,0.030294001,0.024519669,0.039349448,0.029504748,-0.012706809,-0.015466431,0.013524011,0.034479175,0.009576886,-0.059677526,-0.06034665,0.03246175,0.070515536,-0.030125061,-0.037760306,0.05317573,-0.028909788,-0.0051064207,0.0048925304,-0.028088689,-0.023158787,0.07226699,-0.017438084,0.0057441783,-0.04175851,-0.0257686,-0.05546373,0.034436252,0.0006170468,-0.019889623,0.0039290637,-0.066385396,0.04374511,-0.011766965,0.14687487,-0.0027581316 +1.1.3.12,"A flavoprotein. Can also use 2,6-dichloroindophenol as an acceptor.",384,0.99999994,-0.043392114,-0.04744014,-0.07022929,0.02928379,0.016315848,0.004551386,0.07597979,0.07893174,0.06156906,-0.0709859,0.021494424,-0.011903318,-0.089942046,0.013089905,-0.068008,0.099244684,-0.005219863,0.032838393,-0.08654551,-0.0028446515,-0.05876966,-0.0052722935,0.020727068,0.009536216,-0.027502347,0.021544417,0.02307052,-0.011027132,-0.004061493,-0.034528483,0.06317184,0.07718576,0.039948754,0.02739011,-0.070397794,0.015749104,-0.04777168,-0.031766426,0.0014837752,0.01062264,0.039227907,-0.023461573,0.035987444,0.0020760454,0.014945098,-0.049133133,-0.040659327,0.11190788,0.067704864,0.018327745,0.009559543,-0.0078108697,-0.1318434,0.06982155,0.015052934,0.013554973,-0.08788143,-0.020593045,-0.040831875,0.034181476,-0.039346166,-0.02690957,0.05372427,0.004619195,-0.020808049,-0.060148694,-0.02373436,0.001883092,0.06481586,-0.00076774915,0.028542804,0.017813329,-0.03797805,0.044440463,-0.01943344,0.04761411,-0.012320157,-0.03241099,0.11461536,-0.021891482,0.0028075434,-0.004335114,0.06581684,0.08952094,0.09032499,-0.013699691,-0.05520938,0.014175703,-0.046993762,0.0694819,0.0033712902,0.055531215,0.060296662,-0.04846691,-0.02555898,0.034725517,0.015328003,-0.055296,-0.090302534,0.035756834,-0.039455067,-0.053082414,-0.0008974463,-0.014675802,-0.060295478,0.0035014602,-0.048193328,-0.025354223,-0.0018577754,-0.08810438,0.0061403797,-0.055562105,0.04164404,-0.045742072,0.0072954623,0.055771753,0.024424957,-0.029309787,0.038981527,0.016139185,-0.036036983,0.057501644,0.047496464,1.8403089e-05,-0.077312425,0.020061603,0.010684089,2.994828e-33,0.027642911,0.06027359,0.010224114,0.086758085,-0.022867251,0.095019504,-0.03949429,0.0171395,-0.0039028341,-0.124769196,-0.038182646,-0.012130285,-0.004870442,0.03830392,0.10018026,-0.010331494,-0.021342373,0.046961945,0.084219314,-0.09710886,-0.018152244,0.03722957,-0.05537028,0.022127846,0.013308505,-0.00043988726,-0.041385636,-0.034585096,0.07651428,0.02976015,-0.00422114,0.01444959,0.03076828,0.01477927,-0.07563692,0.0029373055,-0.059324678,-0.08788862,-0.05240731,0.011243834,-0.0014416435,-0.02091436,-0.07530443,0.029128699,0.025350349,-0.03926055,-0.041207258,0.040562954,-0.061167058,0.06970207,-0.0157452,-0.01981473,0.08957488,-0.011698594,-0.0627151,-0.0013416748,0.02347462,0.03160686,0.016432466,0.027581144,-0.00809232,0.11908233,-0.039833654,0.03024792,-0.034631047,-0.023074823,-0.102899514,-0.07530936,-0.048988767,0.05482315,0.029147834,0.020196116,0.07017942,0.052680157,0.000493889,-0.04601903,-0.021225786,-0.006685206,-0.006859709,0.020118553,-0.060909323,-0.05478641,0.026120637,0.08069567,-0.1040006,0.075251155,-0.009040537,-0.062022403,0.005968704,-0.044920005,0.022593139,-0.049689297,-0.059606295,-0.024928898,0.03109102,-2.9891956e-33,0.011823698,-0.12255079,-0.004067217,0.14935859,0.093342,0.0080766985,0.034921292,-0.08331101,0.06307249,-0.028769411,0.03190433,-0.062037967,0.037917666,-0.04784013,0.030519115,0.041134816,-0.03783538,0.07840635,0.022213051,0.04653261,-0.019877018,-0.022613505,0.01734561,0.109197594,0.035980005,0.01879835,0.022748945,-0.16062528,0.008959836,0.052267235,-0.09654133,0.03837149,0.01669888,-0.06262583,-0.017825088,-0.0035078686,-0.008638168,-0.101572506,-0.08110437,0.051755864,-0.04087073,-0.009234122,0.042305157,0.066307016,0.015301442,0.0396126,0.016525995,0.06766977,0.031007363,-0.015233103,-0.0015301891,0.007325374,-0.08401859,0.14160392,0.0411085,0.0014100678,0.06962045,-0.039252352,0.021088691,0.012443931,-0.046659566,-0.09660634,-0.0064471476,0.017064467,0.04911627,0.03921186,0.006778127,0.13505131,-0.028453507,-0.06775433,0.1396702,0.0049943835,0.114719324,0.059919786,0.035800476,-0.05742433,0.001551908,0.01880845,0.020153692,0.016896078,-0.10532422,-0.044142302,0.015508395,0.0019522436,0.01386755,-0.12713757,0.012602992,-0.026365997,-0.054692157,0.047231387,-0.033691965,0.03678987,-0.079024844,0.0053257635,0.026342385,-2.7073304e-08,0.032893404,-0.110535994,0.009355848,-0.03274744,0.040580027,0.0041618966,0.013837328,0.02713979,-0.007239543,-0.027580958,-0.0048659,0.08698075,-0.0108152935,-0.01394309,0.012123126,-0.041023012,0.026916685,0.007238834,-0.04238422,-0.027995216,-0.037316814,0.013261423,0.0027192857,-0.05118538,-0.050321907,-0.036943354,-0.0033903155,0.026865095,0.09704612,-0.024360482,0.04559196,-0.003952496,-0.037732415,-0.05830938,-0.053421054,0.09217221,0.027011542,-0.053343326,-0.054801095,0.083302006,-0.06167132,-0.050713215,-0.06358931,-0.007963293,0.0246614,-0.050147954,0.030827533,-0.020369655,-0.03785223,-0.00751473,0.012369188,-0.017249819,0.023002433,0.02024798,-0.05876374,-0.02306406,0.02889948,-0.036376383,-0.026146537,-0.098615386,-0.00841164,0.03409965,0.1166602,0.06579225 +1.1.3.13,"The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism [4]. The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.",384,1.0,-0.010977921,-0.093309596,-0.14108929,0.004600745,0.09292145,0.024476388,-0.13383359,0.017965756,-0.0075230137,-0.016648917,0.03846132,0.00084282306,-0.12122897,-0.00019339105,-0.05658507,-0.0054317317,-0.03791834,0.037329003,0.020422239,-0.03323105,0.06329704,0.01096972,0.016319407,-0.00687479,0.065129265,-0.0050916565,0.010209256,-0.06137709,0.008479608,-0.05103587,0.069669046,0.04788639,0.018421566,0.0059887995,0.012363737,0.018537903,-0.0013009219,-0.0020444826,0.07538671,-0.012271889,0.052541822,0.013506115,0.07522174,0.022199815,-0.060040742,-0.026282836,-0.024519023,0.057884276,0.05661683,-0.052147396,-0.016073367,-0.0670799,-0.022316711,0.040319704,0.02485502,0.052703198,0.00862264,-0.070411295,0.09832213,0.036696963,0.026206,-0.0045840708,0.0076080863,0.026807988,0.0032254332,-0.055056985,-0.022509625,-0.021784354,0.019976897,-0.046237864,-0.035128653,-0.050696578,-0.063774675,-0.020459073,-0.00818164,0.0587493,-0.009580491,-0.027856108,0.02348873,0.020737104,-0.0066344934,0.08555455,0.12353457,0.031870805,0.058283273,-0.024391409,0.027636804,0.047224894,-0.028811073,-0.0068110665,0.040071573,0.022238653,0.0044018114,-0.009946528,-0.095314585,0.06425171,0.07758129,0.06383054,-0.02744599,-0.05085342,0.009952195,0.04364038,0.04875652,-0.053260606,-0.045720942,-0.03849968,-0.005392352,0.12163966,0.04871647,0.0378672,0.021323353,0.016449431,0.0016772426,-0.07037889,-0.0017336311,-0.017512849,0.041787688,-0.044583626,-0.023126574,-0.04957175,-0.012104174,-0.017869554,0.04781096,-0.036326326,-0.018958967,0.018083647,-0.04474373,5.8888105e-33,0.057263445,0.028306937,-0.090745166,-0.07543125,0.057829805,-0.08032585,-0.063249975,0.009161752,-0.03679557,0.00026160764,-0.052999932,0.022653205,-0.009158242,-0.00092418055,-0.069191575,-0.008000445,0.009715211,-0.02801564,0.037692353,-0.013238122,0.0025902006,0.04313816,-0.08082037,0.08683218,0.029924743,0.0166193,-0.014317649,0.06730896,0.04338666,0.00041564502,-0.031254597,-0.05132666,-0.039794274,0.04742204,0.035374247,0.017324727,-0.05610411,-0.047415823,-0.044584427,0.03499465,0.022466723,0.02558793,0.018142855,-0.0147707295,0.052152574,-0.01567761,-0.073927954,0.10222515,0.014370013,0.08818985,-0.008776227,-0.0035432354,0.10470233,0.11972783,-0.047197197,0.049304977,-0.026991587,0.009609739,0.047576647,-0.015342468,-0.038021546,0.026514784,-0.041459613,0.042361222,-0.055659473,0.028573912,-0.07069558,-0.031666145,0.020004272,0.044007365,-0.06924355,0.02682246,-0.086251296,0.036142796,0.05447855,-0.06824529,0.045018345,-0.03496737,-0.024004325,0.04123718,-0.022257088,-0.018701741,0.022784112,-0.029946182,-0.0370311,-0.012066902,-0.12471677,-0.030343706,0.00081797177,-0.078615345,-0.0093530305,-0.025290793,-0.003475658,0.103311196,0.05840764,-4.9910366e-33,0.14682332,-0.10858864,0.089748666,-0.06121578,-0.044417866,0.07185642,-0.020156376,-0.07310133,0.0016593012,-0.07255981,0.05250883,-0.0069129677,-0.026345303,-0.007580042,0.016954666,0.035813022,0.035940614,0.108475246,-0.013615161,0.028931333,-0.06782005,0.14649266,-0.011455055,-0.07285242,0.06779824,-0.026846038,0.011695936,0.0016284619,-2.1630181e-05,0.026391381,0.029576134,0.048821684,0.011503341,-0.016091172,-0.1246649,0.0051798816,-0.059939917,-0.03766713,-0.019411514,0.05998845,0.067138046,0.02865677,-0.05575155,0.049990464,0.09566307,0.004100685,-0.12503402,0.02441933,-0.0050786263,-0.012777607,0.0014744108,0.012567569,0.015488005,0.026983373,0.069081604,0.015268954,0.0993193,0.01157575,0.018124938,-0.057726663,-0.042732004,-0.0132402135,-0.0074790437,0.018806195,0.11191947,0.035279747,-0.07420698,0.11755393,-0.004826639,0.004927837,0.05995366,0.07338738,-0.033209763,0.07968165,0.0027490547,-0.003618861,-0.0682575,0.029315805,-0.026318202,0.038462464,0.03479327,0.037756287,0.063709065,-0.035490748,-0.079507135,-0.050119936,0.05161477,0.063899696,-0.05652909,0.030196214,-0.050277296,-0.021120599,-0.016297145,0.08237176,0.06261815,-4.2179366e-08,-0.026419016,0.05339974,0.005078804,-0.071278445,-0.029924067,0.04174967,0.038336903,-0.024444766,-0.014068328,0.02497236,-0.06551616,0.08104144,0.023074558,0.026083438,0.025272926,0.03610026,-0.03803658,-0.061544247,-0.0147376,0.050512794,-0.028134398,-0.015398593,-0.024006838,0.08722144,-0.09952839,-0.04468543,0.059011653,0.052293133,-0.040999208,0.04180187,-0.085818574,0.07068025,-0.028797746,-0.04280694,-0.094200455,0.030049434,-0.017318098,-0.07661892,-0.023321975,0.065515354,0.018151864,-0.086548425,-0.023507379,-0.051775984,-0.06663312,-0.051889453,0.036073234,0.02985422,-0.0034923581,-0.025321925,0.0049229497,-0.0014228671,-0.019028872,-0.038053915,-0.052614633,-0.039841466,0.0154388305,-0.02939863,-0.07583375,-0.07780115,0.023817178,-0.053699825,0.15323916,-0.01958006 +1.1.3.15,"A flavoprotein (FMN). Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids, and was previously listed as EC 1.1.3.1, glycolate oxidase; the B form preferentially oxidizes long-chain and aromatic hydroxy acids. The rat isoenzyme B also acts as EC 1.4.3.2, L-amino-acid oxidase.",384,1.0,-0.030472688,-0.07876535,-0.089213386,0.07954723,0.07842173,0.043160923,0.006554251,0.020293768,0.037338194,-0.12857777,0.052892383,0.052763768,-0.10941745,0.02332504,-0.05649472,0.0032676193,-0.059240587,-0.018040285,-0.10325522,-0.00070260675,-0.0016252195,-0.017628087,0.03815071,-0.020618118,-0.020932328,-0.07534957,0.02613258,-0.011191153,0.009784688,-0.065978006,0.12576509,0.013988376,0.07209054,0.036448106,-0.049310952,-0.012260402,0.0141522465,-0.071833804,0.0023221506,-0.008640432,0.031853467,-0.01808271,0.022456534,-0.049911883,0.049113482,-0.031765856,0.009155878,0.02826798,-0.0013993398,0.062726095,-0.01606858,-0.051266696,-0.12328648,0.10290947,0.006437038,0.024164142,-0.055924565,-0.01770059,-0.03988006,0.077870555,-0.02279616,0.044309657,0.047405478,-0.0069734827,0.05640271,-0.0390296,0.012435667,-0.053645357,0.019786691,-0.004597122,0.015771408,-0.06883155,-0.0879684,0.028227456,-0.004997559,0.068354614,-0.10470286,0.02362967,0.0032670177,-0.038795374,0.014010831,-0.02447637,0.00364798,0.11379476,0.03265264,-0.09475302,-0.09037389,0.008619389,-0.041039582,0.07117714,-0.025915617,0.06426827,0.060007043,0.012595079,0.03320666,0.050597917,0.074860565,0.046958476,-0.07600167,0.02315732,-0.051160693,-0.0010747694,-0.018890569,-0.0035488605,-0.03363906,-0.025888747,-0.00021155029,-0.0029133996,0.062068623,-0.08657641,-0.0074192546,-0.0022425964,0.027661601,-0.0969748,0.0082491245,-0.01715431,0.00012610471,-0.034399815,0.009885052,0.04087333,-0.02461413,0.0766191,0.06161288,0.09020734,0.019207299,0.009958446,-0.092206195,3.5383412e-33,0.06070128,0.005742569,0.013920775,0.01819292,-0.018844286,0.008598128,0.029319426,0.0034024476,0.032108273,-0.014606836,-0.097756684,0.040630803,-0.004758132,-0.0007306462,0.016499937,-0.0023179892,-0.042768292,-0.02052138,0.086168885,-0.04222691,0.053236164,-0.03184437,0.001857058,0.011187875,0.04488239,-0.042607706,-0.058344755,-0.0056853234,0.010829282,0.027743233,-0.024325771,-0.060769144,-0.078063905,0.0034345733,-0.036161534,-0.037897926,-0.051015597,-0.057555668,-0.081206195,0.07255704,0.008584011,-0.055272188,-0.056689065,-0.02805203,0.075903706,0.043981604,-0.11279775,0.08716056,0.059121385,0.07607057,0.05519257,-0.06994076,0.10762625,0.031858344,-0.03364699,0.0073618605,-0.018229231,0.030225592,-0.03428461,0.041773327,0.010918071,0.07683574,-0.019397981,0.033709705,-0.03193913,0.013722042,-0.061247703,-0.013341352,0.00046992386,0.010229607,0.042829953,-0.00067190157,0.09975974,0.003433965,0.04222205,-0.04023089,-0.111032896,0.00070883334,-0.014088828,0.02819085,-0.024864871,-0.011707592,-0.0600935,-0.001072813,-0.07412569,0.053903766,0.029231988,0.011628436,0.007353517,0.014685305,0.06446363,-0.018428694,0.0010998732,-0.048658088,0.027468655,-2.8999361e-33,-0.014483614,-0.07044343,-0.08639216,0.009186864,0.017155932,-0.013307431,-0.0062810564,-0.02677211,0.009345437,0.026297327,0.0031972069,-0.081365205,-0.009943851,-0.04826596,0.040645245,0.002195653,-0.05785632,0.06877378,0.05148706,0.0042166403,-0.099275514,-0.020947035,0.030032996,0.120128416,0.057677105,0.013287483,0.023405617,0.030875176,0.054149434,0.08855561,-0.05257667,0.08967098,-0.041530754,-0.048011493,0.043340527,0.053957727,-0.049648304,-0.03616028,0.00047572225,-0.036101386,-0.043074705,0.054534726,0.046884384,0.048185572,0.07968045,0.105031826,-0.011931996,0.040189814,0.043415464,-0.011335234,0.0056556994,0.040643252,-0.051879704,0.0728927,0.01958093,0.046500817,-0.031298775,0.08367569,0.0047351974,-0.012600128,-0.02489623,-0.09186774,0.037667144,-0.0362949,0.024759825,0.023952998,0.014072404,0.11407505,0.031539544,0.017624548,0.10568752,-0.0561493,0.070474185,0.048357055,0.032778952,0.019483835,0.02538363,0.078257784,-0.047189586,-0.05081168,0.010802452,-0.008788414,-0.028472032,-0.07965322,-0.03881793,-0.094676234,-0.027243918,0.086712316,0.0694166,0.033420376,0.031602226,0.011547117,-0.06972808,-0.061806925,0.0011928185,-4.2034795e-08,0.03401876,-0.058841202,0.02660856,0.028366396,0.11395296,0.037064582,0.04376467,0.012981063,-0.0015560141,-0.0014250332,-0.0018551153,0.07979161,-0.018587628,-0.016639385,-0.0159699,-0.038023587,-0.018659111,0.08167886,0.013076051,0.03393529,-0.06704011,0.019427262,-0.08519298,0.011853449,-0.048201963,-0.054344002,-0.01956224,-0.004507473,0.09168495,-0.015833715,0.065218896,0.05954711,0.027412819,-0.032930873,-0.14085941,-0.046850502,0.061118364,0.0020413697,-0.055194594,0.0266604,-0.10441425,-0.074553505,-0.030580726,-0.053888697,0.029406574,-0.051769312,0.039889753,0.03567881,-0.014579385,-0.048810348,-0.007869933,-0.018340489,-0.03423368,0.007910501,-0.07567195,-0.05072602,-0.0023924776,-0.037841275,0.0060912664,-0.10842738,-0.04607446,0.07924878,0.15088226,0.025095101 +1.1.3.16,"2,6-Dichloroindophenol can act as an acceptor.",384,0.99999994,-0.034951523,-0.05937463,-0.007710369,-0.014667649,0.028772656,-0.0327319,0.053820003,0.08639835,0.06484177,-0.022106126,0.018355155,-0.027614718,-0.09858017,0.009501879,0.0069161407,0.11198875,-0.08748277,0.058503993,-0.11329921,0.07803289,-0.0058602444,-0.024609905,-0.006582836,-0.01223003,-0.03878566,0.050139654,0.01607893,0.008464012,0.009732248,-0.039630745,0.03720186,0.07215241,-0.006721821,0.06304918,-0.012006132,-0.0024045315,-0.01732214,-0.019921413,0.01821543,0.05070518,0.012991358,-0.035234176,0.012454941,-0.029878888,-0.0164082,-0.035039358,-0.05248047,0.086575165,0.05813959,-0.10278391,0.06556295,0.043347426,-0.056442432,0.08475181,-0.056604218,0.06124263,-0.09022785,-0.0034368124,-0.025226451,0.029057242,-0.016417073,0.0020558408,-0.014648969,0.01857303,0.007625906,-0.0010624203,-0.03614972,-0.06502964,0.006716415,0.005448703,-0.0018366083,0.014563883,0.04786315,-0.06619804,0.031047832,0.011113353,-0.016403986,-0.021867028,0.045476586,-0.060340412,-0.034554623,-0.02072484,0.074108005,0.0691593,0.050206956,-0.05019733,-0.037023515,0.021062363,-0.031948823,0.09374352,0.0030922692,0.025418838,0.054167975,-0.07930911,-0.0599524,0.04677426,0.0047689937,-0.0005386288,-0.020055365,0.048987094,0.017289624,0.027031956,-0.0994056,-0.04615588,0.006724927,0.010215767,-0.040367186,-0.019152565,-0.007236064,-0.04265889,0.0007285813,-0.065145396,0.08904775,0.049220957,-0.021864979,0.058638915,0.015778055,-0.03411027,0.036344785,-0.042167373,-0.010223917,0.005442902,0.0285599,-0.017741378,-0.09799936,0.042902675,0.035284545,1.3611946e-33,-0.024694895,0.03439593,0.0594299,0.049148593,-0.041072533,0.08674289,-0.0894634,0.007750066,-0.0024787697,-0.13419524,-0.054364495,-0.02501664,0.020585712,0.07414982,0.049363475,-0.022032006,-0.0016562308,0.11274391,0.092423774,-0.042340007,0.0005533523,0.04375169,-0.09549584,-0.019772885,-0.021614583,0.08670816,-0.04143545,0.01984168,0.06392523,0.0061965208,0.010472492,0.012202588,0.052375127,0.106171064,-0.080191016,0.040317774,-0.0060316073,0.005410171,0.023844834,-0.093166426,0.002531117,0.01947707,-0.07782638,0.050724767,0.050905906,-0.014603471,0.042594004,-0.06604889,-0.016311772,0.047704916,-0.07982891,0.011245067,0.03634437,-0.054134004,0.040062446,-0.026551949,0.024324361,0.041749008,0.029810283,0.022811918,-0.019738965,0.13592803,-0.027641049,0.017816268,0.009783733,0.020977156,-0.076480106,-0.05340829,-0.064829595,0.07875771,-0.061745994,0.008433809,-0.0032400668,0.06413728,0.054919448,-0.05507719,0.047290254,-0.021015082,0.012265636,0.021683168,-0.051062383,-0.041041635,0.06585001,0.03776259,-0.12299259,0.04219904,0.0030686334,-0.09579939,0.007337914,-0.0125458995,0.092438534,-0.07612437,-0.08218698,-0.017410165,0.03292264,-1.52551295e-33,-0.011398191,-0.04800595,0.0049933223,0.06970353,0.05681235,0.042535443,-0.015699472,-0.052043073,0.081737176,-0.009094197,0.08129827,0.047177717,0.050324496,-0.041852444,0.026021605,-0.009788469,0.01441143,0.090021364,0.015805665,0.015264161,0.004985052,0.0059120464,-0.05543474,0.09195954,-0.017053507,0.056637634,0.037731934,-0.14307359,0.06693751,0.03747357,-0.04651353,0.052260045,0.025476681,0.020848142,0.050665595,-0.050544273,-0.06633697,-0.054685798,-0.10203059,0.03627204,-0.051128417,-0.059279215,0.00554159,0.039984778,0.002627782,-0.029855475,0.058066126,0.0026772746,-0.020320596,-0.044421207,-0.003325998,-0.008134489,-0.07719682,0.035856884,0.06449834,0.009609271,0.056763228,-0.106247224,0.022704447,-0.00011886308,-0.012818198,-0.030774865,0.010203709,-0.014003334,0.01375242,0.009255265,-0.042149898,0.16101505,0.0063456497,-0.055679776,0.11838025,-0.03931061,0.0802719,0.008524703,0.018393617,-0.098852985,0.005499416,-0.05330527,0.019552523,-0.016531806,-0.13585964,0.031219678,0.015185347,-0.023220755,0.01086799,-0.13635004,0.03668369,-0.012257292,-0.092903554,0.084106885,-0.00779851,0.05823908,-0.019857282,0.054740984,0.048617367,-2.4763882e-08,0.017707406,-0.12272914,0.06559795,-0.036061767,-0.04388942,-0.003125659,0.059117615,0.057212435,-0.05215974,0.013188819,0.008690064,0.047683366,0.048712645,-0.011324358,0.011623363,0.026301421,0.0060797697,-0.063721806,-0.059958044,-0.013655738,-0.034557354,-0.00043283254,-0.017252594,-0.09822572,0.011866118,-0.007183253,-0.0131376935,0.040330574,0.01925506,0.0031932984,0.043817457,-0.04261517,-0.076657474,-0.0024783937,0.02878368,0.062403735,-0.02086422,-0.097276576,-0.08155199,0.045701843,0.004396314,-0.06869168,-0.0778013,0.05709579,0.02383079,0.007263288,-0.0108259665,-0.037237782,-0.033151746,0.010362045,0.003642277,-0.0013486632,0.041581795,-0.001426693,-0.06399171,0.02677082,-0.0005942155,-0.025760243,-0.026083857,-0.06264959,0.011369797,0.020350272,0.12311341,0.033527985 +1.1.3.17,"A flavoprotein (FAD). In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyse the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. In plants, the first reaction is catalysed by EC 1.14.15.7, choline monooxygenase, whereas in animals and many bacteria, it is catalysed by either membrane-bound choline dehydrogenase (EC 1.1.99.1) or soluble choline oxidase (EC 1.1.3.17) [6]. The enzyme involved in the second step, EC 1.2.1.8, betaine-aldehyde dehydrogenase, appears to be the same in those plants, animals and bacteria that use two separate enzymes.",384,1.0,-0.115975045,-0.11613498,-0.07293543,0.05620369,0.10787413,0.05661824,-0.07556832,0.032400575,0.043405186,-0.019768713,0.028533291,0.024756117,-0.043611865,-0.04704537,-0.07767467,0.09142129,-0.07585524,0.014805348,-0.017641263,0.018579576,0.021615349,0.0051229335,-0.011146092,-0.010125331,0.070761815,0.0057958355,0.011449601,0.011469569,-0.05604852,-0.02902757,0.037039757,-0.04601024,0.11664354,-0.045087233,-0.04478127,-0.010735181,0.03537965,-0.08320702,0.056138173,0.032140207,-0.01224214,0.034689512,-0.050603997,-0.015860977,0.0644475,-0.032063007,-0.010755906,0.053140547,0.02083045,-0.017240772,-0.032101758,-0.042412683,-0.08679867,0.0041974545,-0.014411357,0.014630148,-0.004769119,-0.036318257,0.02524809,0.041912965,-0.0152346175,0.0073479833,0.02640522,-0.026827114,0.043147895,-0.067387104,-0.08036996,-0.09256614,0.07524587,-0.053899936,-0.040890556,-0.05635782,-0.02374653,0.05490805,-0.014036834,0.03617683,-0.063467264,0.023736171,0.011009189,-0.014250729,0.019499948,-0.050601266,-0.0065890807,0.040052,0.054607507,0.0020423445,-0.05218474,0.05968912,0.019635294,0.08488102,0.009528975,0.016007654,-0.006650994,0.033350166,-0.04477485,0.0029472783,0.109603554,0.020506611,-0.00798856,-0.019701373,-0.057253845,-0.014871138,-0.00281438,-0.059223842,0.0059130928,0.0012544644,0.03151631,0.06083668,-0.044203214,-0.001350668,0.007730341,-0.029953757,0.05078242,0.024619741,0.00022612592,0.08393455,-0.0100346,-0.041341662,-0.023274232,0.03332774,0.018236274,0.010182791,0.04792029,0.087326,-0.0094069755,0.03434285,-0.06353278,4.1393998e-33,0.058800615,0.019092029,-0.024255414,-0.04614447,0.044705417,-0.03084911,-0.09658156,0.00990938,0.026311383,-0.044163942,-0.039112635,-0.037824016,0.035174996,-0.02276372,0.08760462,0.031644817,-0.037985597,-0.08195097,0.09640777,0.011265989,-0.022415353,-0.028581116,-0.030811781,0.0640945,0.10941412,-0.032259133,0.004685035,-0.019007573,-0.005530272,0.023251573,0.011276369,-0.16965567,-0.046118397,-0.0018777874,-0.016773203,0.027668199,-0.076427914,-0.11655267,-0.08699394,0.024548464,0.05450947,-0.013519837,0.012723218,0.018191645,0.05390128,-0.01913041,-0.07768745,0.1515096,0.015358017,0.07496209,0.030178173,0.019349903,0.10754773,0.040981762,-0.04922232,0.07107691,-0.039199103,0.011710884,0.047688436,0.08917458,-0.013368464,0.032575794,0.01231952,-0.0005189288,-0.019351238,0.00278907,-0.061647344,-0.06396584,-0.014384343,0.04385987,-0.036125176,-0.026545417,0.05056153,0.0049533793,-0.032865964,-0.0048979674,-0.038079895,0.04331029,0.038519517,-0.096115254,0.010710863,0.07813445,-0.00055871235,-0.013631674,-0.02438046,0.03183839,-0.0033101314,-0.009576726,-0.023940837,0.033662356,0.059610497,-0.04013047,-0.036477312,0.014270735,0.013966944,-3.2081316e-33,0.06280911,-0.1073332,0.028729087,-0.06885355,-0.076079436,0.066298746,-0.0672708,-0.11985028,0.06979232,-0.034240175,-0.031554148,0.010939914,0.05677821,-0.04571364,0.021195378,-0.0136877615,0.008461144,0.05835132,0.0047062086,-0.050078478,0.016837552,0.06952864,0.08271194,0.03296775,-0.00096056843,-0.04138405,0.026921375,0.05050142,0.07627329,0.086400315,-0.005701684,0.07598944,-0.0030846358,-0.07802107,-0.05689618,0.059539575,-0.046745636,0.0094572855,0.07903143,0.09947914,0.0012537295,-0.006708188,-0.04366245,-0.028492788,0.05515175,0.1280559,0.011435257,0.012073112,0.0176504,-0.073916376,0.08753597,-0.019916516,-0.04337379,0.044515282,0.059265833,0.05104038,0.030376025,0.03543285,0.012103583,-0.09887841,0.020428907,-0.037443634,0.054760788,-0.018842822,-0.024098996,0.05300402,0.019720273,0.08900559,0.03169915,-0.037293807,0.013680879,-0.0013511309,-0.004148308,0.10403736,0.012711156,0.0065828213,-0.006297102,0.008734985,-0.033578753,0.01782398,-0.023240225,0.040439058,0.0062049706,0.003039632,-0.041234646,-0.0499342,0.004695906,0.14666453,0.016303565,0.039484117,-0.043045357,0.012734341,-0.06761656,0.01689874,0.09610304,-4.1495582e-08,0.009378586,-0.025967414,0.042203024,0.016190462,0.030334808,0.02327075,0.034216292,-0.018897422,0.023535509,-0.085009694,-0.06755827,0.11632813,-0.010826546,0.0052894535,-0.008201363,0.006557937,-0.03473985,-0.0050043217,-0.022365669,-0.0013994762,-0.028279582,0.034304775,-0.056619085,0.045631453,-0.026147718,-0.07631916,-0.028874047,-0.004912932,-0.009981842,0.014642299,0.020697612,0.056651637,-0.011290537,-0.10724933,-0.08530822,-0.05201089,0.030853773,-0.034303535,0.07809901,0.06400387,-0.036116954,-0.05426921,-0.06298825,-0.018874325,0.013865137,0.03270028,0.023881085,0.04691154,-0.034474283,-0.030602476,0.050274182,-0.04796957,0.009051952,-0.07809444,-0.11129466,0.010993479,-0.018775998,-0.12134711,0.00033388648,-0.05100364,-0.04143702,0.002762275,0.19810663,-0.031737648 +1.1.3.18,"Acts on secondary alcohols with five or more carbons, and polyvinyl alcohols with molecular mass over 300 Da. The Pseudomonas enzyme contains one atom of non-heme iron per molecule.",384,0.99999994,0.0030711198,-0.114421755,-0.07821955,0.06631459,0.097022615,0.06993988,-0.029919155,0.048757967,-0.004233655,-0.010234517,0.014467997,-0.078480616,-0.14369664,0.08413573,-0.008605984,0.009615139,-0.09291214,0.0074732415,0.029068995,0.08297846,0.04096488,0.024411457,-0.032233045,0.027220493,-0.009324204,0.07434162,0.083469935,0.047903124,-0.023752034,-0.026053306,-0.036829133,-0.037664503,0.072729334,-0.025660338,0.08733619,-0.042533536,-0.04452721,-0.023432178,0.09114847,0.00019823168,0.061744995,-0.023857003,0.023293536,-0.056608222,-0.025883425,-0.021367488,-0.0017304573,0.039883967,0.054473132,-0.037365433,-0.039777514,-0.03222917,0.0005107963,0.119864635,-0.0065769665,-0.0031072963,0.059447728,-0.025140084,-0.007485347,-0.0023115566,0.008635358,-0.055281293,-0.055092685,0.05430506,0.0049364115,0.0041933428,0.057137135,-0.010137446,-0.040629968,-0.0066744164,-0.016628075,-0.011737897,0.03663763,0.05854524,0.03383665,-0.09444056,-0.008373832,-0.029355908,0.040202424,-0.010263056,-0.071566276,-0.016831351,0.060525354,0.10013209,-0.014990469,-0.009284839,-0.024029296,-0.017873077,-0.050356284,0.059382733,-0.077562,0.012636195,-0.009576707,-0.14305565,-0.0100681875,0.07257389,0.024232572,0.08691913,0.09298799,-0.05534835,0.009664051,0.05233813,-0.014209749,-0.13834564,-0.021465542,0.014676023,-0.006493009,0.032869533,0.100586124,0.033583455,0.009312437,0.010453806,0.08232972,-0.05410282,0.013762333,0.038607497,0.12467843,-0.034113612,-0.07074314,0.008923925,0.0009472908,-0.047785062,0.1052337,0.06745696,-0.027818859,0.0077868057,-0.08665302,-6.3413874e-36,0.04847126,-0.030278316,-0.019472849,-0.03761232,0.005590592,-0.0700292,-0.09601245,-0.021487933,-0.043749787,-0.014300742,-0.033757027,-0.03548021,0.043405868,0.007918582,-0.009738827,-0.04673806,0.042965267,-0.020764014,0.07600577,-0.029415239,-0.001124483,0.091021255,-0.02611935,0.04011715,0.042896006,0.08089065,0.04649392,-0.0020547074,-0.030237008,-0.010523632,0.014870334,0.027645824,-0.06818274,0.0020033778,0.08049773,0.022290358,-0.032455623,-0.008849946,-0.025143662,-0.006971649,0.123720616,0.089297295,0.013936065,-0.04807733,0.029964332,-0.04868833,-0.09387422,0.06471279,-0.010309291,0.12587036,6.481279e-05,-0.047759313,0.026624164,0.034698136,-0.051815804,0.0060598687,-0.044755623,0.003265057,0.07372431,0.038993664,0.032394927,0.025893733,-0.039222356,0.034723524,-0.016027294,0.025027772,-0.025342619,0.013173876,0.052204438,0.026613973,-0.091118075,0.03836826,0.040015686,-0.036970656,-0.015309118,-0.0404795,-0.028531918,-0.051976737,0.06469511,0.059021004,-0.07756385,-0.07975778,0.054970503,-0.04983249,-0.087562524,-0.0012113218,0.009309554,-0.055193618,-0.08275536,-0.055914387,0.07110528,-0.12414965,-0.033839274,0.0021587268,0.028786749,-2.5944986e-33,0.025163244,-0.07553426,0.06387744,-0.034495246,-0.042976916,0.007481459,-0.032720454,0.00029023734,-0.026836112,-0.037545886,0.120253265,-0.0045668846,0.0045637274,-0.020720368,-0.017421829,0.08259312,0.0016644018,0.011535943,0.033970285,-0.014442948,0.034245953,0.041477736,0.03130191,0.041088127,0.06771474,-0.0033996855,-0.07437003,0.005501689,0.060863554,0.071534425,0.040942326,0.033217434,0.00016062638,-0.056364756,-0.024217974,-0.043110497,0.004926081,0.053061053,0.011406143,-0.019930698,0.08698904,-0.026193742,-0.014803767,0.042174615,-0.031598747,0.06659759,-0.095250614,-0.03692293,-0.031485334,-0.05755694,-0.0018599113,-0.0104751075,-0.054388802,0.036546867,0.021827495,0.00094522885,0.023915926,0.013791076,-0.083895214,-0.028125973,-0.06536347,-0.047379248,0.015688712,-0.025843866,-0.01353501,0.044885736,-0.056359854,0.06849908,-0.056789815,-0.029512128,0.036739953,0.056644417,0.020931236,0.0061063124,-0.09360719,-0.097252786,0.005453838,-0.04185262,0.0050611687,0.04072395,0.009702811,0.02137487,-0.049053933,-0.017726408,0.018534658,-0.05064535,0.06481853,0.038864736,-0.10550005,0.041403662,-0.02005912,0.0672454,0.063261434,-0.008949265,-0.028261552,-2.9474494e-08,-0.039176702,-0.020165773,0.07344396,0.014388974,-0.00029759965,0.007914618,-0.007239257,0.0027421394,-0.04285966,-0.0076987245,-0.027221138,0.057937663,0.0027112155,0.0050332337,0.07433927,-0.040351886,-0.1087674,-0.0052704765,-0.03743664,-0.082327485,-0.038583826,-0.015638646,-0.05358643,0.036796555,-0.05194918,-0.034528747,0.022322305,-0.037138954,0.0080677,0.0019306277,-0.06840927,0.042595,-0.06709491,0.023449678,-0.055656325,-0.019394355,-0.0021581652,-0.05876242,-0.099348195,0.0016405062,0.042482316,-0.11786848,-0.12213798,-0.016633714,0.023832723,0.03851258,-0.057722546,0.029418295,0.037722807,-0.006876643,0.12528098,0.0074389833,0.062613405,0.048086476,-0.071629256,0.08037185,0.019620344,-0.010474828,-0.014128685,0.0022304954,0.0625542,-0.024599245,0.10154708,0.02600857 +1.1.3.19,"A flavoprotein (FAD), requires Mn2+. The enzyme from the bacterium Pseudomonas putida is involved in the degradation of mandelate. 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+1.1.3.20,Oxidizes long-chain fatty alcohols; best substrate is dodecyl 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+1.1.3.21,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.1.3.23,A flavoprotein (FAD). The product differs from thiamine in replacement of -CH2.CH2.OH by -CH2.COOH; the two-step oxidation proceeds without the release of the intermediate aldehyde from the enzyme.,384,1.0,-0.07433387,-0.05021485,-0.08448987,0.017269423,0.12632777,-0.0071034837,-0.006524935,0.064255536,0.04720355,-0.06045883,0.029778669,0.02358254,-0.0751026,-0.037363824,-0.06402622,0.029437115,-0.036080863,-0.022188008,-0.07986799,-0.015998611,-0.027473157,0.038428407,0.020214751,-0.010822693,0.03472955,0.0018334286,-0.0017391659,-0.033026826,-0.0028892728,-0.03513911,0.06387387,0.07910708,0.050340287,-0.014740906,-0.06542357,0.017633926,0.038974714,0.015138002,-0.033790648,0.00420405,0.037486024,0.00235482,0.0137890875,0.011836006,0.030534713,0.021522418,-0.02073082,0.07477651,-0.05100985,0.08789333,-0.018567437,-0.029882614,-0.11185824,0.043055024,-0.013680985,0.041680086,0.0045575285,-0.031488687,-0.04396612,0.03366775,0.009625975,-0.034858506,-0.0037637095,0.013477047,0.08729137,-0.09831376,-0.0068103764,-0.082511134,0.03934577,-0.055185933,-0.0065004798,-0.01875745,-0.058654796,0.024717253,0.018829716,0.034061216,-0.059810538,-0.037798934,0.057066802,-0.005528696,0.06441951,-0.020959133,0.089979514,0.067814104,0.09144556,-0.046576757,-0.00068598957,-0.04012481,-0.046791807,0.038946018,0.005220299,0.044273596,-0.0012747113,0.0148335695,-0.080979705,0.07925928,0.076884784,-0.007721046,-0.04581911,0.016761333,-0.042942822,-0.024591854,-0.020070631,-0.055469714,-0.058681905,-0.054185715,-0.038097292,0.0373474,-0.0062040547,-0.015561407,0.017582735,-0.011299579,0.0063832127,-0.04744089,0.005968482,0.02396009,0.007233199,-0.04152808,-0.004177899,-0.02382145,-0.02838264,0.078372546,0.07481384,0.083299875,-0.0031913756,-0.0096084755,-0.068872906,3.770643e-34,0.06357693,-0.003541533,-0.06192275,-0.017297031,0.024855189,-0.02880113,-0.05510731,0.0047285534,0.051167045,-0.014345901,-0.021599881,0.018867638,0.019269807,-0.07051863,0.07448417,0.0034861846,-0.046374463,-0.05269538,0.12273402,-0.10907256,0.04278057,0.06957908,-0.036288608,0.081219934,0.02072865,-0.03765611,-0.0059954533,0.07590444,-0.021321185,0.030354667,0.02568832,-0.051817242,-0.056098368,-0.048877627,-0.0510807,0.025243223,-0.09190295,-0.0815032,-0.10699077,0.027268436,0.0208737,0.0028067643,-0.010175312,0.0051456713,0.0071052387,-0.067634776,-0.091668956,0.09524744,0.0015331578,0.08085169,0.0016339947,-0.008289581,0.10436054,0.063173085,-0.07520039,-0.021746878,-0.020093491,-0.00666688,0.056667496,0.029404476,0.014342134,0.082691394,-0.019701485,0.12278448,-0.119892456,-0.0047390177,-0.03558537,-0.033524588,0.0074596684,0.098367296,0.05447642,-0.0005198809,0.11493221,-0.011959901,0.039249007,-0.06511263,-0.029112391,-0.0005650976,-0.0062163887,-0.008222583,0.01851112,0.016095208,-0.02032349,-0.033735562,-0.059014942,-0.017046463,-0.023551777,-0.052120928,0.0018817341,-0.005146339,0.06657457,-0.027198963,0.026355578,0.0070685437,0.0863578,-3.0607474e-34,0.022790594,-0.11841389,0.06720791,-0.0026443389,0.04140255,-0.0028969115,0.034170084,-0.037817266,0.02729916,-0.063022554,0.03331398,-0.06196715,-0.055072535,0.027060112,0.07469587,0.030166417,-0.036014948,0.013062886,0.055753306,0.019534959,-0.037128426,0.005961693,0.021192005,0.06443749,0.032845624,-0.0035488976,0.025099674,-0.052819166,0.039881874,0.030579858,-0.045704227,0.014387066,-0.06502523,0.013303686,-0.09009735,0.015510803,-0.013409259,0.0008319387,-0.04507267,0.06114253,-0.019583466,0.00077179354,0.021571564,0.050021,0.05989137,0.04090997,-0.045079693,-0.020367047,0.060305547,-0.083505966,0.0823546,0.057649504,-0.018987758,0.065115996,0.05635307,0.05338645,0.07132461,0.046659928,-0.006515401,-0.004143124,0.018288987,-0.119126335,-0.0009400345,-0.018092297,0.06367418,0.052911174,0.0048597376,0.12792613,0.032263387,0.011998678,0.10193814,-0.009462143,0.03135088,0.020236582,0.018678077,-0.039691556,0.0022482679,0.0914505,-0.033117358,0.027511777,0.023697505,-0.020853419,-0.000986559,0.05155601,-0.119569086,-0.09573144,0.0073460825,0.05996095,-0.024894658,0.052846782,-0.024232937,0.058806572,-0.0011561911,-0.019577457,0.12184769,-3.2066854e-08,-0.009391736,-0.091696106,0.019348314,0.010378288,0.08491433,0.047416538,-0.060386576,-0.00856883,0.015846107,-0.04561698,-0.06494359,0.15983726,-0.017950058,-0.0036358028,0.053048212,-0.03574901,-0.03986153,-0.004907264,-0.0073428657,0.005906206,-0.11061773,0.091301434,-0.028966501,-0.015805906,-0.104947895,0.01556782,-0.011703032,-0.026508708,0.025479695,-0.013833649,0.011094271,0.054114416,0.019333899,-0.06765157,-0.1186147,0.0012464565,0.091512084,-0.06770445,-0.06093251,0.0276495,-0.09573895,-0.033069313,-0.050267816,0.0035726598,0.02803632,-0.060892597,0.05403531,-0.024728404,-0.06741292,-0.03131058,0.0085190125,-0.0105397105,-0.017091257,-0.013039024,-0.027377067,-0.0286764,-0.03372275,-0.06484744,-0.024479493,-0.048128076,0.065482505,0.041538984,0.15330724,0.028611137 +1.1.3.24,"A flavoprotein. Acts on the 1,4-lactones of L-galactonic, D-altronic, L-fuconic, D-arabinic and D-threonic acids; not identical with EC 1.1.3.8 L-gulonolactone oxidase. (cf. EC 1.3.2.3 galactonolactone dehydrogenase).",384,1.0,-0.04967538,-0.11228581,-0.049648955,-0.011926391,0.084665984,0.02531374,-0.06265027,0.03586247,0.044995435,-0.07654789,0.037837368,-0.058940273,-0.094413035,-0.019003382,-0.062166117,0.025577318,-0.07105564,0.02322414,-0.079276636,0.02837808,0.071986645,0.011654656,0.039451074,0.034492593,0.07186739,-0.007324599,-0.01251763,0.009662503,-0.05051394,-0.09203823,0.08387344,0.0031674376,0.044380795,0.052443396,-0.043775138,0.07499038,-0.0023955829,-0.04657866,0.0517399,0.020395802,0.031386424,-0.09177547,0.090447426,-0.0020150319,0.012775306,-0.0048090084,-0.015929904,0.10124994,-0.027178092,0.059819374,-0.025831185,-0.104072966,-0.09017544,-0.0029680307,-0.017256754,0.08677197,-0.0054278537,-0.022154383,-0.031138295,0.030082574,0.04282538,0.011251682,0.060492296,0.03581048,-0.016413765,-0.04944792,0.07367919,-0.075164594,0.040306423,-0.023054268,0.0406777,-0.043768503,-0.029949209,0.042582087,0.00026235823,0.13051744,-0.05422285,-0.018426616,0.010390735,-0.07061961,0.0790011,0.010750585,0.039428968,0.039273914,0.057106696,-0.10633283,-0.049606588,-0.003171784,0.030560827,0.0282069,0.027815862,0.0036425758,0.025927491,0.03331408,-0.02217269,0.0793896,0.057970304,-0.025090748,-0.08880748,-0.012490017,-0.045144707,-0.04269347,-0.025611462,0.030277433,-0.0038145264,0.02309502,-0.0546237,0.001685067,-0.07065432,-0.062709875,-0.0072938288,-0.08505225,0.06796074,-0.019322034,0.029499216,0.043171365,0.013375123,-0.046777833,-0.069073826,-0.014877324,-0.030130962,0.05609344,0.039631665,0.057606608,0.0063404874,-0.004759698,-0.06587263,2.2360652e-33,0.13933977,0.012870686,0.0071459403,-0.01489036,0.0378137,-0.00784961,-0.078927726,-0.0067635435,-0.034811545,0.02876999,-0.09798055,0.052984547,0.07149767,0.012968665,0.016362045,0.06953472,0.012198007,-0.032453522,0.016726607,-0.06832495,-0.029084984,0.03389533,-0.040740475,0.035157822,-0.0103825675,0.022202091,-0.002496204,-0.032019716,0.06013083,0.026624119,-0.064767115,-0.10473317,-0.077352576,0.038801067,0.0033029888,0.056420933,-0.09777919,-0.092192344,-0.078586206,0.025819642,-0.0006775439,0.0013940347,-0.08841952,-0.047229834,0.034523766,-0.01290823,-0.031181507,0.0972955,0.037505638,0.042494014,0.05864593,-0.050126262,0.061609164,0.067871496,-0.036473397,0.041278988,-0.07247162,0.0913601,0.042222098,0.015763888,0.050348356,0.026596855,0.02745716,0.023438103,-0.0037684795,0.049209908,-0.05516727,-0.04978345,-0.015158722,0.022253659,0.059212837,-0.055676907,0.09252421,0.020174345,0.03145892,0.022750912,-0.07361615,-0.06091172,-0.049736984,0.040077463,-0.057989527,-0.011672218,-0.019386988,-0.0054811137,-0.051538054,0.07346324,0.017278057,-0.020944962,0.036664367,-0.019071018,-0.050590675,-0.028173203,0.028807614,-0.066783786,0.0292185,-1.3634396e-33,0.004697982,-0.08176639,-0.02043207,0.027586767,-0.008574355,0.018129935,0.0141016105,-0.024112185,-0.017846534,-0.010544011,0.061568845,-0.07885445,-0.024593096,-0.12899442,0.04715482,-0.01030536,-0.009752375,0.050985124,0.018843926,0.054193355,0.00054513663,-0.010005938,-0.0005021526,0.11110054,0.046263743,-0.0070818844,-0.038066316,-0.040483873,0.019889437,0.04070513,-0.044466205,0.08966228,-0.0031101634,-0.07935825,-0.043517943,0.06662836,-0.04136566,-0.01162594,0.026498392,0.06393019,-0.053346977,0.04304935,0.10622809,0.065220095,0.116949156,0.09041488,-0.038196474,0.026157424,0.041351624,-0.04775016,0.023348562,0.04398571,-0.018607266,0.09422561,0.07193767,0.08611017,0.011699726,0.058904022,-0.03029503,-0.05674798,-0.041631516,-0.09343395,0.011084955,-0.07741566,0.08860367,0.06287478,0.015506841,0.12616445,0.03911305,0.0037813208,0.114935175,-0.011570764,0.018708004,0.043715097,0.052438032,-0.040856704,-0.039615393,0.0037818016,-0.026753588,-0.051919308,0.02920975,-0.004431323,0.033386838,-0.012281152,-0.0006004818,-0.09591059,0.020144826,0.06720405,0.046599727,0.029453829,-0.045326035,-0.028874908,-0.051293243,-0.0055661984,0.071457945,-4.241471e-08,0.09066061,0.025558984,0.015244352,0.00086953194,0.06500944,0.012524051,-0.013130233,0.029741352,0.030253341,-0.05722046,-0.018572656,0.102784514,0.0027632208,-0.000755051,0.03125479,-0.009226587,-0.00171835,0.059284516,-0.041447468,0.010558394,-0.006678324,0.014131443,-0.104047,-0.025017027,-0.038184132,-0.032282837,-0.010035206,-0.019756198,0.05583526,-0.029467136,0.06337321,0.035734054,0.05388989,-0.08714029,-0.08081747,0.022962973,-0.014245804,-0.026129188,-0.023423122,0.016718995,-0.08833479,-0.026546726,-0.027891591,-0.008296671,0.01956745,-0.02917923,0.007155851,0.02283545,-0.010719932,0.007127051,-0.032355215,0.0028154266,-0.03448034,0.012210782,-0.05123776,-0.035214797,0.03385303,-0.054697733,0.0021194154,-0.12333764,-0.0001277783,-0.042084835,0.13258484,-0.06271429 +1.1.3.28,"Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.39, nucleoside oxidase (H2O2-forming), as it produces water rather than hydrogen peroxide.",384,0.99999994,0.043015532,-0.081314765,-0.056067407,-0.0825001,0.08307813,0.02751187,-0.07041433,0.029531447,0.0074959304,-0.0021621792,0.047627833,-0.028933052,-0.087605484,0.04719495,-0.014701308,0.039098937,-0.060036965,-0.013571228,0.08936369,-0.058623407,0.068628594,-0.038230196,-0.031475525,-0.011441907,0.0050806454,0.033975653,0.028203273,0.014319859,-0.007331076,-0.06899391,-0.027471092,-0.10178029,0.072678395,-0.026731048,0.016702212,0.09131656,-0.084342346,-0.033454426,-0.0007110606,0.02109397,0.021146804,-0.041713398,-0.06727055,0.044790417,-0.013533749,-0.016739998,0.05685597,0.054472275,-0.054243926,0.011316468,0.0311471,-0.023585469,-0.042429414,-0.08314538,0.00010116253,0.06656844,-0.042361442,0.013536924,-0.02430472,0.025581744,-0.014546928,0.005424301,-0.03910273,-0.01081175,0.061808355,-0.033473212,0.08521319,-0.05493915,-0.00417989,-0.03683823,0.009290389,-0.085937545,0.015525063,-0.0012103101,0.027229061,-0.038495727,-0.03231145,-0.08240504,0.0052063,0.0019084112,-0.04190075,-0.031514045,-0.008887252,-0.011408999,0.028825538,0.01739089,-0.05521884,-0.0065032835,-0.011763869,0.006057443,0.034056604,0.046386242,0.00059365586,-0.010528934,0.010526587,0.061152197,-0.015137331,0.12735748,0.061212927,-0.08935828,0.024292046,0.09924865,-0.119239844,-0.06392672,0.034734145,0.02703446,0.06117059,0.0009908921,-0.020532956,0.0579231,-0.041555528,0.03885448,-0.04059021,0.0020888883,0.021051342,0.060266104,0.028937344,-0.041469995,0.0075813895,0.0022929106,0.0033094443,-0.008823351,0.05038261,0.109045744,-0.049299818,0.013610165,-0.01090405,4.532027e-33,0.037635174,0.024390927,-0.041190084,0.0016747774,-0.022909475,0.047554217,-0.07181424,-0.021449028,-0.025671711,0.011481364,-0.12565342,-0.071919285,0.05099424,0.040929902,0.018274898,-0.1068051,0.0029067474,0.0894307,0.034490343,0.058523018,-0.030006263,0.06480121,-0.024196865,0.027048288,0.05603019,0.04310964,-0.09943037,0.034436062,0.04048904,-0.053974614,-0.03278723,-0.047732253,-0.013962408,0.0014223249,0.024570389,-0.038354885,-0.089345165,0.029997075,0.022430314,0.024205495,-0.004181056,0.034553185,0.017786376,-0.027476903,0.049473286,-0.027667196,-0.04511607,0.05965016,0.0011669977,-0.00025992194,0.024222504,-0.036081575,0.107718706,-0.08515342,0.063456945,-0.0062575596,0.014053761,-0.002845181,0.056706525,0.094140016,0.03267018,0.08722793,-0.004507884,-0.014192136,0.04717318,0.052009534,-0.07746563,-0.049163084,0.052772265,0.0690033,-0.0153394,0.016449535,0.038427107,-0.040607158,0.042512186,-0.02298433,-0.10929651,0.025124151,-0.0016853842,-0.0065104985,-0.014992508,0.019951522,-0.020003064,-0.03815478,-0.031797603,0.02943931,-0.016357569,-0.056567345,0.05665154,0.1004287,0.06129349,-0.04431924,-0.01318292,-0.06892934,0.07857236,-5.7411713e-33,0.03387757,-0.088813275,-0.013745297,-0.08832283,-0.10026609,0.04446408,-0.0022177785,-0.07166856,0.058403417,0.04038575,0.008598954,-0.014461699,-0.069104455,-0.05945786,-0.07284702,0.036067832,-0.0020956658,0.13839662,0.00913212,-0.0335566,-0.0020082335,0.078365386,0.02775653,0.069112204,0.050928216,-0.030551434,0.06185775,-0.0025476885,0.10096574,-0.03727642,-0.06462161,-0.02942966,0.012091565,0.008306632,0.029051779,0.0466611,-0.06291639,0.043196164,0.011118727,-0.042850565,0.0006335764,0.05972135,-0.02701187,0.060103655,-0.030526338,0.039454166,-0.06854925,-0.031553023,-0.06015513,-0.100272335,0.014126371,-0.019316016,-0.017601298,-0.005346988,0.06741505,0.0066204173,-0.0019943784,-0.021689586,0.081386365,-0.07001147,-0.039320685,-0.063090414,-0.048105154,-0.032653324,0.036915414,0.016165933,-0.08173169,0.08766227,-0.0449111,0.014910512,-0.025488114,-0.005519683,-0.009928312,-0.0065277615,-0.08100185,-0.078289695,-0.03202856,-0.03812368,0.038909413,-0.040132087,0.0006800027,-0.00031969996,-0.055244107,-0.03758309,-0.0016184425,-0.0659428,0.069597036,0.052138537,-0.02682741,0.04995678,0.047034517,-0.007935526,-0.013970694,0.07105318,0.027844125,-4.495989e-08,0.070112385,-0.06922797,0.05884143,-0.046896573,-0.015601589,0.036886998,0.01967716,0.0070213135,0.04504312,-0.033066668,-0.07087367,0.08436075,0.054059997,-0.035561264,0.08070377,0.06738401,-0.0492333,-0.01084595,0.033112813,0.014168028,-0.085073955,0.0474183,-0.17443438,0.053574685,-0.016590487,0.0026146097,0.07290647,0.07877407,0.017975798,-0.04091194,0.06829534,0.013168105,0.019401254,-0.05216515,0.037403047,-0.023946045,0.029620968,0.004889912,-0.0142653,-0.006260851,-0.081781246,-0.097513676,-0.012326737,0.034560796,0.009283055,0.01270796,-0.03841433,0.028477605,0.024850506,0.01639374,0.040096916,-0.028416945,0.03161619,-0.08331518,-0.030938344,-0.03186161,-0.018129867,-0.11396592,0.020527951,0.0022400736,0.03693951,0.032495163,0.23540033,-0.009385133 +1.1.3.29,"The enzyme, found in bacteria, also acts more slowly on N-acetyl-D-mannosamine.",384,1.0,-0.001201426,-0.07580307,-0.056321148,-0.021344652,0.06330393,0.012253976,-0.06573145,0.028918775,0.04052149,0.07288702,0.059173156,-0.0033438522,-0.03051071,0.061159052,-0.048525605,0.0424772,-0.0032294053,-0.004841372,-0.0054548234,-0.016985247,0.06076086,0.008531329,0.020984795,-0.0450568,0.01595028,-0.0025461963,0.030129539,-0.038922828,-0.028267335,-0.14445037,-0.02218625,-0.010355377,0.05383045,-0.019894121,0.08688188,0.07730557,0.033284914,0.036322396,0.08493357,0.007905998,0.009915499,-0.007630418,-0.013595909,0.007069569,-0.024828896,-0.014376631,-0.0435035,0.03533885,0.065421075,-0.005806025,-0.06927106,-0.011726592,-0.00592252,-0.0047230995,-0.0024249635,0.05812902,-0.045055546,-0.024458269,-0.0074926666,0.023372706,0.01624137,0.02169167,0.08646336,-0.019537881,0.079627566,-0.08091999,0.060351647,-0.09619551,0.003446886,0.0434873,0.019763825,-0.03269588,-0.037394885,-0.0018576079,8.5225445e-05,-0.10930088,-0.008952088,-0.11071484,0.037562754,-0.0264637,-0.017533317,0.03980762,0.028284818,0.03552355,-0.02262758,-0.006768021,0.052784875,-0.046561785,0.06071704,0.015631177,0.010095165,-0.022511065,0.0052029705,-0.07645106,-0.025712023,-0.0658391,0.011272275,0.08635865,0.004014281,-0.0055159647,0.015698798,0.041805394,-0.069666825,-0.08099549,-0.01843042,0.015005161,0.06686155,0.03425511,0.027288973,0.046305947,0.028585337,0.041070763,0.0037760274,0.064924166,-0.11796463,0.06322303,0.038579553,-0.08577211,-0.0681052,0.024308106,0.0003180203,-0.0336219,0.013899711,0.049554415,-0.0044271825,0.10464863,-0.054966785,-2.6816979e-33,0.019656321,-0.06044701,0.03917674,-0.045454264,0.04289783,-0.010936981,-0.060895324,-0.003958945,-0.012430365,-0.06473229,-0.11558503,-0.0878654,-0.0026007942,0.07640662,-0.048728015,0.03748717,-0.05733117,0.0023317125,-0.019311493,-0.03396395,0.0010094121,0.022994986,-0.05765576,0.019541992,0.026347619,0.021685954,-0.006503905,0.08384254,0.030746935,-0.018129218,0.04451917,-0.046028115,-0.038155302,0.010998294,0.044845935,0.03414942,0.0062848763,0.011626797,0.04548534,0.0045802603,-0.016175644,0.08939353,-0.016834658,-0.027257405,-0.028579043,-0.029507728,-0.05679577,0.07974645,-0.004308354,0.069681324,0.065157145,-0.055614103,0.05123602,-0.007650812,0.015925447,0.046479587,-0.056019492,-0.03357754,0.053148557,0.0719054,0.0016210708,0.005434447,-0.015517249,0.037119664,0.02304149,0.049597584,0.006862476,0.00651245,0.07521508,0.01670594,-0.08934337,-0.019703683,0.037067525,0.015803393,0.018450286,-0.066752076,-0.041619238,0.0009894416,0.028924631,-0.042109016,0.027613236,-0.05702638,-0.019569159,-0.038515203,-0.07791222,-0.010905134,-0.010180807,-0.11619577,-0.01889304,0.032533802,0.061868098,-0.08112667,-0.13916981,0.023205848,-0.010235815,-8.3485136e-35,0.08769462,-0.13398248,0.09205718,0.01619536,-0.07350118,0.08468158,0.028096564,-0.011957699,-0.0009257327,0.0001321348,0.07236375,-0.012296019,-0.020606939,-0.0002524653,0.051988754,0.030217066,0.04486007,0.043040816,0.02084108,0.017341048,-0.04762986,0.09548719,-0.032002114,0.0008742038,0.015809987,0.00836063,-0.1020663,0.06626513,0.0051238355,0.019148044,-0.03590162,0.03215098,-0.0542623,-0.07343509,-0.015273701,0.0413912,-0.04375198,0.0010011916,-0.057734236,-0.03970221,-0.046278976,0.021160543,0.03277335,0.005918412,0.013860801,0.062428363,-0.055683136,-0.03909964,-0.064857826,0.008824226,0.0619991,-0.052172787,0.022383817,0.011808605,0.043234356,0.066574395,-0.06078447,0.011624259,-0.029266652,0.024559101,-0.020466384,-0.07706055,0.010488575,-0.002243777,0.016307214,0.040831354,-0.043714814,0.08495245,0.09431867,-0.0504727,0.004289328,0.06628858,0.06646035,0.06789791,-0.09706022,-0.062125895,-0.06409819,-0.05967832,0.0026430842,-0.052185044,-0.07693638,0.02445705,-0.032194797,-0.07745961,-0.13871488,0.033781197,0.06468525,0.06564314,-0.012308749,0.13176507,-0.059619036,-0.039166052,-0.06350265,0.01994237,0.01644502,-2.575811e-08,0.0762069,-0.031378448,0.11836839,-0.058099996,0.052237436,0.05350271,-0.009007161,0.0797952,0.08131836,-0.04081275,-0.0044859094,0.16450243,0.07436979,0.021612994,0.0055607324,0.01700492,-0.032015957,-0.047298774,-0.022741318,-0.005889676,-0.13975295,0.06927597,-0.054552313,0.025784073,-0.009253303,-0.009888504,0.069456495,0.08512852,-0.057100907,-0.053582024,-0.061167832,0.049791683,-0.009783566,-0.07869655,-0.045217622,0.011937659,-0.038962964,-0.06446267,0.029414322,0.0316314,0.01573032,-0.0010961841,-0.048661567,-0.0110875415,0.016030475,-0.016328441,-0.005990109,-0.024564061,-0.002823475,-0.021636294,0.035626985,0.014682711,-0.069849774,-0.06348939,-0.075077474,0.016241295,-0.04763129,-0.11604843,0.0068706684,-0.028132055,0.019939639,-0.04799955,0.14215139,0.00886269 +1.1.3.37,"A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot [1]. With L-galactono-1,4-lactone as substrate, the product is L-ascorbate [3]. The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS no.: 5776-48-7; formula: C6H8O6), although it was referred to as a five-carbon compound [1].",384,1.0,-0.017102836,-0.09892621,-0.035109397,-0.028861078,0.08766245,0.048092697,-0.0077446057,0.12438365,-0.0048652147,-0.03370318,0.02610467,0.023343123,-0.07058387,-0.014593779,-0.078403495,0.0662205,0.005857727,0.06859351,-0.0651288,0.055102922,0.07824225,-0.01666245,-0.004937245,0.038939156,0.11800168,-0.042955548,0.0014966605,-0.017363176,-0.047562268,-0.08057272,0.05421814,-0.013026439,0.065531254,0.027580129,-0.030360773,0.04230453,-0.016489523,-0.019796092,0.047637768,-0.0009291729,0.056859713,-0.06830102,0.058807272,0.012708998,0.017146578,0.0025827351,-0.06836012,0.11378731,0.026184706,0.048639137,-0.029237326,-0.03275009,-0.077817686,0.008391286,-0.04031621,0.0116487425,-0.058095764,-0.028194752,-0.031140631,0.036754455,0.04971027,-0.011780093,0.038176473,-0.01987818,-0.011090904,-0.012676473,0.061363924,-0.076407745,0.075687714,0.02901412,0.026357498,-0.029464925,-0.009768147,0.036262117,0.033491187,0.12516765,-0.018201953,-0.019772585,0.05952036,-0.058984783,0.1024785,0.050463855,0.051500432,0.04044567,0.008951415,-0.015749048,-0.029758705,0.0341689,0.020309854,0.018127533,0.011151082,0.011087644,-0.06291422,-0.00392194,-0.06431739,0.032616112,0.082312725,0.0010869824,-0.0035859523,-0.017266192,-0.037153374,-0.05471416,-0.017127648,-0.014797496,-0.03964155,-0.027764635,-0.0010464651,-0.04634629,-0.011487354,-0.10842069,-0.04064579,-0.028525248,-0.014986571,-0.0005128553,-0.07493606,0.057791494,0.049916413,-0.053960927,-0.037815627,-0.018456077,-0.0051136976,0.07435334,0.081686676,0.05443071,-0.012550881,-0.035453375,-0.011191517,9.567318e-34,0.04648878,0.0460698,0.017892802,-0.005424069,0.02174949,0.004102958,-0.099291615,0.031026382,-0.051737268,-0.02280418,-0.063011944,-0.037601247,0.06318125,0.030094596,0.01954455,0.060397822,0.019729596,-0.06626931,0.0711753,-0.095533095,-0.050378002,0.04801564,-0.06986332,0.076908015,-0.03248906,0.015197801,0.025461975,0.03775045,0.070035316,0.030259078,-0.07293316,-0.043110367,-0.05898147,0.02965557,-0.006132002,0.059459314,-0.15436675,-0.054449316,-0.009142304,0.05049567,-0.009658112,0.009844684,-0.08605733,-0.004484197,0.0067682704,-0.028247135,-0.046498075,0.033652343,0.020572916,0.02525815,0.024832536,-0.014974908,0.067362845,0.054427408,-0.06531602,0.0027644425,-0.10183831,0.051293697,0.04152414,0.027886381,0.017553627,0.043898374,-0.004728094,0.04310879,-0.03145649,0.054318987,-0.041205727,-0.0037199866,-0.015064877,-0.019604128,0.06570928,-0.09308184,0.07954317,0.030947383,0.007179427,0.03126221,-0.022281546,-0.012086894,-0.04081703,0.04515388,-0.029283134,0.036649022,-0.043664314,0.0143071655,-0.10597455,0.08427981,0.012755282,-0.020286815,0.0070181214,0.026059194,-0.01352338,-0.05119185,-0.0076135923,-0.01742978,0.03323553,-1.6069904e-33,0.031990424,-0.079259634,0.027035005,0.009053423,-0.015029072,-0.0065899678,0.09323478,-0.060158644,0.02600965,-0.0375713,0.1032991,-0.08667558,-0.060021102,-0.04323881,0.03703874,0.082594246,-0.060004704,0.06649193,0.028992273,0.050383206,0.031716447,0.066137224,-0.027506653,0.098444685,0.04423354,-0.019426825,0.015930735,-0.060116053,0.023718929,0.072691575,0.013491705,0.036464363,0.005673987,-0.027444674,-0.04013679,0.057428822,-0.045360513,-0.023459943,-0.03863118,0.026824612,-0.041222405,0.05224068,0.08260282,-0.019794824,0.098918974,0.08181119,-0.038172673,0.019697048,0.053994607,-0.026062705,0.026762262,0.009748418,-0.047402702,0.024782611,0.03561787,0.10583272,0.084401354,0.06801056,-0.043838646,0.009701159,-0.0435748,-0.09145994,0.0069755786,-0.14710683,0.07700257,0.059904054,-0.012416698,0.06369396,0.0058854115,-0.053795483,0.132111,0.03888447,0.013399357,0.073163,-0.018499121,0.015196073,-0.070144676,-0.009631566,-0.10088219,-0.028232688,0.033201754,-0.0023130614,-0.008452786,0.05653108,-0.059733495,-0.10161094,0.024022141,0.09304572,-0.018025262,0.031011095,-0.033483263,-0.027602926,-0.06775964,0.069505244,0.09544961,-5.0687266e-08,0.09086009,-0.032003224,0.0233639,-0.08129085,0.007996513,0.0059919837,0.038814448,0.0056634867,0.03916711,-0.07230104,-0.05497077,0.0986101,-0.04792056,0.013730878,0.002197455,-0.06030221,-0.07107672,0.011314785,-0.03170864,0.00526955,-0.03874105,-0.019234775,-0.108887196,-0.08250852,-0.069730505,-0.06695157,0.037427206,0.009241363,0.042665247,-0.074936874,0.04925313,0.024235347,0.02313155,-0.041937947,-0.040166635,0.03279906,-0.04816666,-0.067663476,-0.004690814,0.06906826,-0.045441255,-0.04760673,0.017222473,0.016885802,-0.007508579,-0.063911006,0.007328794,0.011999311,-0.032876037,0.042322498,0.003479272,0.009500106,-0.038848393,-0.020588435,-0.037610978,-0.008887022,-0.02049307,-0.050975088,0.005446019,-0.12277497,-0.012583281,-0.035774786,0.12265686,-0.026662273 +1.1.3.38,Vanillyl-alcohol oxidase from Penicillium simplicissimum contains covalently bound FAD. It converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes. The allyl group of 4-allylphenols is also converted into the -CH=CH-CH2OH group.,384,1.0,0.046295226,-0.048490144,-0.095045626,-0.017813027,0.12222427,0.03415753,-0.06830172,-0.0010830977,0.06353356,-0.105106466,0.05776693,0.008569927,-0.07837573,0.019644994,-0.05335209,0.013651927,-0.04386893,0.027526056,-0.11693171,-0.028366342,0.005333866,-0.07934082,0.05994476,-0.044751354,0.06734861,0.0026022426,-0.0030701356,-0.004001093,0.04796334,-0.054688845,0.10186511,0.023948569,-0.05287311,-0.07603035,0.09646866,-0.008630798,0.026451724,0.008090413,0.063294366,0.008612935,-0.0076880963,-0.035679244,0.025046118,0.008381128,-0.061415534,0.026595721,0.036634233,0.054532558,-0.054582264,-0.007439775,0.054452922,-0.038515687,-0.028826328,0.023064185,0.008364129,0.04845717,-0.005872528,-0.01983821,-0.025992298,0.062205754,0.039082788,0.054205578,-0.04006773,0.037921727,-0.13186722,-0.02758022,0.0031683834,-0.077843405,-0.006248995,-0.013016068,-0.058665466,-0.050333865,0.033298716,0.0026959975,0.07333834,0.04062164,-0.0743993,-0.05287855,0.084023945,-0.027123028,-0.01449888,0.06775552,0.057236917,0.11536753,0.06801695,-0.09688734,0.061327655,-0.07320441,0.03623462,0.036785126,-0.045140967,0.035844855,-0.06393009,0.012617799,-0.10176692,0.00053896714,0.109619215,0.01857636,-0.05690657,0.022772735,-0.0085303495,0.065855265,-0.016969075,-0.104546376,-0.073723435,-0.04491536,-0.0026816279,0.05770924,-0.030668907,-0.04351936,-0.01457682,0.021803373,0.024872364,-0.048305336,-0.007092933,-0.036626793,0.0005691809,-0.07977044,-0.0043144315,-0.081831805,-0.047719754,0.060615055,0.060592346,0.07191708,0.055695754,0.009044504,-0.008178507,4.3873607e-33,0.03653518,0.053131133,-0.05378117,0.0054300763,0.007351132,-0.04746771,-0.07804851,-0.020785224,-0.020391205,-0.0023702995,-0.041480374,-0.061248932,0.0072971545,0.022698015,-0.003034468,0.0038346453,-0.011233488,-0.042299457,0.020418048,0.009020958,0.04400687,0.09867808,-0.03203559,0.07250362,-0.013310755,0.004353738,0.023729585,0.058471564,0.077545375,0.035282232,-0.033008616,0.0140330875,-0.07545902,-0.08438359,-0.054605167,0.12826444,-0.080194496,-0.07285003,-0.0182858,0.06347629,0.0416091,0.061546568,0.030681929,-0.09216262,0.02797373,-0.016491104,-0.03405508,0.13056569,0.046959836,-0.014411477,-0.019695139,-0.017173776,0.040984474,0.048178956,-0.04643924,0.0089219045,-0.04613065,0.033911124,0.032001935,0.02038894,-0.04040822,0.017575126,-0.040624883,-0.030107837,0.016202418,0.01470157,0.019199803,-0.1519662,-0.011363056,-0.013401831,-0.06271596,0.018943107,0.058517516,0.028785817,0.042465057,-0.03993164,0.047848728,-0.023032794,0.10035401,-0.031139836,-0.06969833,0.017899519,0.051713087,-0.12656082,-0.02597474,-0.118245214,-0.041814756,0.00039083185,-0.022854295,-0.0017951798,-0.020914286,-0.07251639,0.03327671,0.03496856,0.0053277663,-4.54993e-33,0.03659531,-0.09612127,0.04178835,-0.024081826,0.027173828,0.053417996,-0.06459446,-0.017409915,0.045844357,0.018141521,0.047424056,-0.0015148798,0.020609437,0.038217444,-0.0016336747,-0.03279734,0.010532045,0.06577303,0.10627463,0.021863412,-0.024340948,0.055835012,0.04728729,0.038423568,0.10343048,0.019621551,0.018236253,-0.013227281,0.002197422,0.03489083,0.0003734089,-0.011711136,-0.038530536,0.0054976894,-0.06979369,0.049166817,-0.035537384,0.0010825295,-0.03899456,0.09055904,-0.033819016,-0.024752343,-0.043886248,-0.0010298863,0.05592133,-0.025414174,-0.10126809,0.018596025,0.012516544,-0.04199209,0.08144204,0.030897819,0.005404895,0.0071582254,0.04622923,0.018532863,0.017159546,-0.055046886,0.03870292,-0.06075464,-0.083965205,-0.00815065,0.019595258,0.016582225,0.014388177,0.016046725,-0.0684838,0.110586375,0.021411344,0.011322174,0.06780123,0.061058305,0.014331141,0.05899307,0.080037534,-0.05549651,0.01357774,-0.0058528446,-0.010286123,0.007094035,-0.012493593,0.00038765877,0.03900038,-0.05060921,-0.086311236,-0.044164486,0.037814606,0.09249971,-0.00097079616,0.035499446,-0.023208354,0.06680293,0.035843328,0.059566732,0.10409346,-3.5513708e-08,-0.024138505,0.03720766,0.011310152,-0.011314769,-0.022430716,0.020506939,9.1548085e-05,0.015210845,-0.011173136,-0.03987678,0.031215813,0.116751984,0.011083995,-0.02186646,-0.018980183,0.065640286,-0.06970178,-0.020624114,-0.019674713,0.03274221,-0.008352991,0.02549035,-0.022373289,-0.010339549,0.0059883767,-0.049454104,0.02827746,-0.011137006,-0.10421956,0.012218367,0.012657561,0.051367175,-0.017602852,-0.06758042,-0.073638596,0.056702018,-0.020826409,-0.009789819,-0.079745434,0.07423638,-0.029360322,-0.07216535,-0.060206003,-0.01458964,0.026097508,-0.022851877,0.0015290787,-0.03133912,-0.02391259,-0.018270567,0.0113546355,-0.015587793,-0.0026129123,-0.04938085,-0.104407996,-0.021693379,-0.067017876,-0.022539305,-0.022357695,-0.11174329,-0.05767491,0.058942392,0.15930381,0.053981043 +1.1.3.39,"A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water.",384,0.99999994,-0.01791263,-0.05258483,-0.08203843,-0.03619455,0.14464532,0.013379984,-0.049381454,0.09845755,0.03952631,-0.016534764,0.009315814,7.129985e-05,-0.12137949,0.015225516,-0.061935972,0.03901639,-0.073680505,-0.004705976,-0.008836571,-0.05009089,0.037183393,0.01136145,0.016567115,-0.0049747233,0.025325073,-0.009659578,0.038626824,-0.016037297,-0.032159124,-0.057541113,0.07535344,-0.039844576,0.11001556,-0.0097186025,-0.024401346,0.07728445,0.0070110485,-0.07097018,-0.011829967,0.011476278,0.05806951,-0.052175365,-0.03535435,0.011376735,0.043972388,0.022526382,0.018164473,0.0680436,-0.04906427,0.05228576,0.0103304675,-0.053422976,-0.11697701,-0.018299244,-0.009141115,0.053082984,-0.030171337,-0.023919078,-0.008458331,0.03359649,-0.026240822,-0.016439237,-0.026517386,0.00092174945,0.04391357,-0.08834127,0.036432415,-0.05536786,0.01097954,-0.053033218,0.02659845,-0.064074464,-0.06971053,0.03084232,-0.0039258716,0.02190141,-0.0610801,-0.062169548,0.0349666,0.0063053854,0.0036641415,-0.019729596,0.06423673,0.07175842,0.053889647,-0.0040262486,-0.07679973,0.0022226442,-0.041210167,0.032653414,0.0028474303,0.050455082,0.0053123804,-0.002768909,-0.020497821,0.09913552,0.03207519,0.0714271,-0.0064038173,-0.03985397,-0.013860803,0.036091775,-0.05433097,-0.034570497,-0.01877591,-0.01954183,0.021865636,0.0149232475,-0.012891048,0.0031096586,-0.01184676,-0.021148836,-0.0017701144,-0.06958933,-0.010643975,0.04800803,0.00890223,-0.05046821,0.01677795,-0.021862071,-0.028225206,0.06430492,0.10085217,0.112921566,0.014653144,-0.00537394,-0.05629483,5.2042188e-33,0.06476973,0.0070393546,-0.046350572,0.012596371,-0.039100904,0.01952814,-0.077222645,-0.009617599,0.02206141,0.015819287,-0.1050284,-0.035666313,0.049477417,-0.008849971,0.03301996,-0.056897152,-0.017448219,0.039550744,0.037650824,-0.016661614,0.018278643,0.051389877,-0.011618304,0.049218297,0.036900736,-0.0014538862,-0.09187004,0.017932283,0.048585784,-0.014615202,-0.0367162,-0.032018106,-0.035087314,-0.032970756,-0.03912408,0.013672843,-0.13312067,-0.023443902,-0.07203469,0.08119184,0.005850869,0.017986186,0.004856659,-0.03683178,0.07573666,-0.06232262,-0.0835514,0.07369505,-0.0012491789,0.08786499,0.020882819,-0.049072493,0.14145623,0.016000854,0.0071021277,-0.01138823,-0.018865058,0.0014425442,0.06529602,0.07669719,0.044172887,0.11371471,-0.021796415,0.03515966,-0.012922101,0.054726254,-0.05631053,-0.058326643,0.037170142,0.09442166,0.040032785,-0.007250395,0.069858804,-0.028434576,0.04847588,-0.065632865,-0.08742104,0.0015940549,0.00338793,-0.0016893438,0.002559804,-0.0010383399,-0.01691769,-0.01603449,-0.049549952,0.034791023,-0.025471184,-0.039827924,0.026209919,0.04113413,0.067271285,-0.078093,-0.013885496,-0.045680128,0.087608285,-4.47431e-33,0.06061024,-0.08629697,-0.028454477,-0.042058386,-0.026248734,0.033546023,0.029926011,-0.049506813,0.03825905,-0.0072694635,0.034125026,-0.0649606,-0.081967294,-0.01854633,-0.033140533,0.030723494,-0.030452559,0.064673744,0.03318944,0.0256457,-0.05487822,0.04255432,0.0585785,0.098972365,0.08004693,-0.05604932,0.027959103,-0.03801621,0.086857036,-0.0018229835,-0.062438328,0.0094253095,-0.051958617,-0.007974663,-0.016697515,0.055006277,-0.02271018,0.056756385,0.010346401,-0.024616282,-0.01086455,0.035146333,0.015104967,0.078119986,0.012249875,0.0790294,-0.09204097,0.0021155472,-0.021109166,-0.096504964,0.0022519,0.028342688,-0.039982006,0.034755148,0.07566232,0.014956453,0.049217593,0.03945118,0.0019330711,-0.05375866,-0.03357047,-0.100832075,-0.0057130833,-0.03086468,0.082787424,0.095291905,-0.063150726,0.1572093,-0.039023794,0.037302915,0.053193204,-0.004737017,0.0100348685,0.008660408,0.0060291314,-0.08695226,0.008918765,0.032719072,0.04491215,-0.006893256,-0.005920929,-0.0017423613,-0.04311527,-0.015026338,-0.039625186,-0.11138981,0.010063252,0.058207035,-0.015564227,0.044064347,-0.0066352547,0.021281142,-0.0017818777,0.026964776,0.04814082,-4.4339316e-08,0.03132174,-0.11191028,0.0020257542,-0.025953012,0.05638591,0.046087176,-0.0021084733,0.012141897,0.01934345,-0.043133445,-0.08103354,0.13345574,0.015671035,-0.03318449,0.079576455,0.027923489,-0.05294146,0.019210078,0.004544588,-0.0034235073,-0.0669953,0.09728362,-0.15490068,0.041036695,-0.035901677,-0.024553204,0.027912209,0.018902691,0.062809974,-0.030933734,0.064528055,0.03512481,0.02565747,-0.052642114,-0.036186486,-0.021666603,0.041469663,0.008566335,-0.039226975,0.00042368277,-0.1060781,-0.06667945,-0.022576984,-0.020757124,0.030867416,-0.0048283455,0.018660419,0.009885763,-0.026191203,-0.015734853,0.03422894,-0.020900996,0.0433714,-0.02992504,-0.05514544,-0.05671635,-0.00073168724,-0.1350338,0.013059549,-0.060116146,0.027906507,0.013245405,0.22964518,0.025800915 +1.1.3.40,"Also catalyses the oxidation of D-arabinitol and, to a lesser extent, D-glucitol (sorbitol), whereas L-arabinitol is not a good substrate. The enzyme from the snails Helix aspersa and Arion ater is found in a specialised tubular organelle that has been termed the mannosome.",384,1.0,-0.04751405,-0.05238572,-0.03488483,-0.0389658,0.028797997,0.043915443,-0.10061899,0.014108887,0.062166527,0.070987895,0.060488984,0.036359377,-0.04541527,0.011263388,-0.02755731,0.01812883,0.009683237,0.04922187,-0.056703787,-0.037826806,0.07720638,0.013397246,0.04703074,-0.030334894,0.07338774,-0.04943566,-0.01191811,-0.051643312,-0.0075079375,-0.16180001,-0.004375037,0.002492488,0.018161958,-0.055573344,0.019547587,0.057824537,-0.017296394,-0.01590289,0.057835,-0.054168634,0.05709864,-0.08321119,-0.037899632,-0.031427123,-0.09355726,-0.04886809,-0.057441752,0.031806476,0.05363192,0.038674265,-0.017808916,-0.050257802,-0.034818914,-0.07868003,-0.07702841,0.048714105,-0.02260193,0.037316896,0.026332455,-0.02743368,0.036665276,0.045718953,0.028300954,-0.023257308,-0.023663944,-0.060606517,0.055892203,-0.07322284,0.026059905,-0.029439967,0.020895679,-0.08343518,-0.024376607,0.03790989,-0.010729874,0.013861785,-0.04353789,-0.056088906,-0.018198118,0.04921241,0.05418257,0.069863565,0.047553144,0.055085886,-0.026912786,0.017236209,-0.036189076,0.01013021,0.017865261,0.027170531,0.07077586,-0.029894257,0.004169934,-0.020983526,-0.023106918,-0.040026385,0.074579895,0.08452645,-0.008693736,-0.040387377,0.012167583,0.0059260335,-0.06946198,-0.06399134,0.01935345,-0.005579391,-0.046794806,-0.028102139,0.053863913,-0.10274427,-0.005242389,0.006355573,0.03159859,0.013456775,-0.06298951,0.014853763,0.042947233,-0.08308347,-0.008221524,-0.01098177,0.029617677,-0.071692,0.08059523,0.08176265,-0.041325074,0.0067840256,-0.09964912,1.2803181e-33,0.032928243,-0.04418966,0.03585972,0.03721848,-0.04885051,-0.049040575,-0.020206599,0.058387443,-0.016919795,-0.063130215,-0.1708318,-0.0026894787,-0.0023404595,0.14147824,0.0013097854,0.023100557,-0.02908743,-0.05421205,0.071318105,-0.040644493,0.009088361,0.023811238,-0.024122408,0.025355227,0.072394565,0.051209833,0.028220657,-0.020080464,0.013989371,0.012822066,0.033237115,-0.10495024,-0.04324288,0.095572576,-0.02128716,0.074653156,-0.09025908,0.006482766,-0.039922565,0.006346694,-0.032714773,-0.013074377,-0.013279354,-0.026581386,0.06727871,0.034326687,-0.014042861,0.043813657,-0.037481274,0.014461316,0.09951201,0.027979067,0.026070982,0.0838381,-0.016235206,0.09663747,-0.049088314,-0.014445009,-0.023450058,0.114304446,0.04545201,0.07519516,-0.03588661,0.04198613,0.0005484851,0.08168863,-0.070765525,-0.027964806,-0.033475477,0.0046451846,-0.007844492,0.040474527,0.12526435,0.032610204,-0.012853827,0.049419645,-0.0047913035,0.009552796,-0.0050411955,-0.039338715,0.045431357,0.0125966715,-0.033008162,-0.03883766,-0.09806324,0.011467463,0.051622063,-0.07800028,-0.016560586,0.04665856,-0.017675871,-0.07322558,-0.08151743,0.016339207,-0.009926526,-2.8074585e-33,0.11211228,-0.12215062,0.07341828,-0.024624921,-0.044077244,0.025604516,0.094970375,-0.04654645,0.037988458,0.011965088,-0.019655874,-0.03020777,-0.029663801,-0.0111985635,0.08730269,-0.004279282,-0.022595162,-0.077404216,-0.025819015,-0.008749518,-0.11987222,0.10819168,0.016953886,0.02700271,0.037723366,-0.052343927,-0.033946704,0.014243183,-0.015767297,0.087410435,0.039065227,0.041112937,0.058644924,0.017073147,-0.04760094,0.07456357,-0.09315057,0.0130372895,-0.013965491,-0.015847193,-0.07543178,0.019215783,0.018340683,-0.022056226,0.08565203,0.035228677,-0.09311462,-0.034957726,-0.02019564,-0.06713288,0.077417076,0.013799234,-0.006342579,-0.020873105,0.068202436,0.090007156,0.01752945,-0.014000574,0.0024562494,-0.04422663,-0.012962451,-0.055916194,0.05827036,-0.014605231,0.040848617,0.04038812,0.0050168075,0.018305972,-0.025976844,0.046496082,0.11309856,-0.00891448,0.00029973921,0.081609465,0.007958034,-0.029288024,-0.081732236,-0.0085201105,-0.016295593,-0.0793828,-0.09049595,-0.019751932,-0.024591248,-0.03902311,0.010322949,-0.020287741,0.041163024,0.12702672,0.0026317206,0.055813406,-0.01189694,-0.04195204,-0.06565973,0.0793571,0.08948717,-3.6184755e-08,0.084081106,-0.0051858677,0.058023088,-0.013250652,-0.010477686,0.034385353,0.0546293,0.05677529,-0.017388567,-0.014657239,-0.043422174,0.06642548,-0.03847171,0.0045885937,0.028552892,0.008981659,-0.042909645,0.029454665,0.000463391,-0.04394057,-0.086618684,0.079775475,-0.10193586,-0.015317007,-0.026916184,-0.042528793,0.044136975,0.01679564,0.046358503,-0.00907699,-0.014707619,0.049599905,0.004019287,-0.07712684,-0.025840553,0.0056009833,-0.015188542,-0.05910207,0.014777868,0.07884538,-0.01602999,-0.01832703,0.03496548,-0.020079818,0.016163008,-0.020272031,0.042455945,-0.020808944,-0.00983641,0.0767671,0.03526531,0.020141754,-0.0740187,-0.01455261,-0.08847844,-0.005163568,-0.08094338,-0.028073667,-0.037782587,-0.023753371,0.001985295,-0.0065461164,0.14295621,-0.029422691 +1.1.3.41,"The enzyme from Streptomyces sp. IKD472 and from Streptomyces coelicolor is a monomeric oxidase containing one molecule of FAD per molecule of protein [1,2]. While xylitol (five carbons) and sorbitol (6 carbons) are the preferred substrates, other alditols, including L-threitol (four carbons), D-arabinitol (five carbons), D-galactitol (six carbons) and D-mannitol (six carbons) can also act as substrates, but more slowly [1,2]. Belongs in the vanillyl-alcohol-oxidase family of enzymes [2].",384,1.0,-0.004299235,-0.104830585,-0.13960661,-0.019350704,0.07465225,0.07047225,-0.117844544,0.0285861,0.110574566,-0.011424339,0.021243583,-0.023933554,-0.07546728,0.06322107,-0.033063285,-0.006586401,-0.011242061,-0.042855278,0.0027854498,-0.0107169645,0.116017394,0.046477903,0.050199907,-0.05256112,0.08538482,0.0013439097,-0.009438045,-0.04978223,-0.029644694,-0.09089164,0.06953371,-0.03931613,0.037862863,-0.06429551,0.074796304,0.04711531,0.01040536,-0.06264873,0.07716232,-0.016372882,-0.013926092,-0.05072466,0.0047681653,0.039054863,-0.06187146,-0.011517533,-0.007872994,0.079592064,0.05555815,-0.035974633,-0.006402296,-0.08116278,-0.054754358,0.020213896,0.025503926,0.068184264,0.013915784,-0.024400668,-0.0022305723,-0.0056650555,0.061856892,-0.0005271168,0.034399822,0.015210464,-0.071671166,-0.0331192,-0.010815805,-0.09420867,-0.018104764,0.0028588457,-0.101220645,-0.07284116,-0.00077646674,0.07567141,0.040278196,0.008386951,-0.02946962,-0.07324147,-0.025059361,-0.04732121,0.021716477,0.051765855,0.053757764,0.10278212,0.016273681,-0.04317936,-0.010862456,-0.045834713,0.04437696,0.055900503,0.048701685,-0.018259328,-0.0043716663,-0.03644146,-0.060458165,-0.017195683,0.03754583,0.03736185,0.014818903,-0.03450915,-0.010873986,0.013641724,0.029696105,-0.04690201,-0.03653792,0.020961916,-0.06273541,0.089731805,0.035899606,-0.08411747,0.017626043,0.05067342,-0.009701192,-0.013320812,0.015348941,0.02425381,0.09381637,-0.09760087,-0.0057462757,-0.027820561,-0.03795454,0.020418549,0.11463072,0.091249906,0.00023249416,0.010782899,-0.09081625,3.4643663e-33,0.027646232,-0.015935343,0.0050532245,-0.043612197,0.01142908,-0.049934287,-0.08434792,0.022668114,0.0028228634,0.037440564,-0.083726756,-0.090077505,0.02330055,0.004760107,0.088637054,0.01369293,-0.060945515,0.034964066,0.03330611,-0.01381707,-0.034760185,0.023230284,-0.025970327,0.014400528,0.06709143,0.07336572,0.0147610735,0.03133655,0.0506464,0.0021151432,-0.008181393,-0.028165424,-0.052451745,-0.0011059009,-0.012954089,0.047077276,-0.07280501,-0.019823153,0.026694376,0.0040201405,0.018703034,0.022149913,-0.008928541,-0.023968996,0.056857422,-0.0722545,-0.040375527,0.09203087,-0.007738226,0.09554705,0.027744483,-0.07331859,0.040127367,0.05775015,-0.07068119,0.041718755,-0.050417785,0.0868457,0.056152027,0.07296031,-0.0074029756,0.021100376,-0.01133675,0.038022738,0.022747653,0.04676809,-0.009732471,-0.057066463,-0.041716587,0.07765024,-0.037598424,0.023831127,0.065707915,0.005976368,0.047027964,-0.062110685,-0.05048957,0.03281647,0.07598512,0.04094291,-0.013222443,0.017678248,-0.061800625,-0.11553307,-0.07686284,0.050805528,-0.026063725,-0.11066893,-0.0127161145,0.083812684,-0.019484904,-0.05836238,-0.051291283,0.012060909,-0.0024712281,-5.047453e-33,0.09312397,-0.14910999,0.0826137,-0.04803951,-0.048066985,0.022801954,-0.021386845,-0.024635306,-0.013312835,-0.038809363,0.05944812,0.023741089,-0.02568242,-0.040624272,0.009247756,0.004875439,-0.0482478,0.05209788,0.03276127,0.032483812,0.015730036,0.0956742,0.026747076,0.0023680402,0.103394024,-0.0127522815,-0.019015962,0.016111843,0.05065711,0.049195178,-0.01070811,0.03559477,0.009942437,-0.044129457,-0.04777961,0.039189573,-0.12154456,0.044816308,0.014608692,0.029587423,0.007955494,0.06720095,-0.027594391,0.038764223,0.045458913,0.02769433,-0.1385425,-0.0072969976,0.04862123,-0.07962315,0.00935312,-0.027050814,-0.007492988,0.0013927082,0.01129269,0.069278196,0.043968964,0.012196255,-0.022231583,-0.028508794,-0.07359386,0.00094139203,0.042448312,-0.026722293,0.13802983,0.018328322,-0.04117392,0.0742677,0.016321076,-0.0036058757,0.056411628,-0.05865452,-0.048844896,0.03226298,-0.008277132,-0.0681974,-0.06594749,0.03610418,-0.017331725,0.033735666,-0.019235188,0.02978439,-0.017374858,-0.032812256,-0.027484333,-0.04202771,0.054065637,0.085235864,-0.008600879,0.09149456,-0.04566311,0.03274643,0.007676279,0.037436504,0.07878466,-4.548819e-08,0.02534136,-0.018864494,0.07504942,-0.026621977,0.021137469,0.0012517252,-0.0026851231,-0.027213182,-0.022982458,-0.007695226,-0.04703686,0.084801756,0.0053404155,0.0018752904,-0.0066133165,-0.029221544,-0.11109117,-0.028887901,0.0035471143,-0.0035431301,-0.03760691,-0.012007461,-0.055479698,0.007813912,-0.006318406,-0.084896386,0.05581157,0.027304713,0.00043253088,0.018521678,-0.033661332,0.05441612,-0.048788335,-0.020148981,-0.037053104,-0.009983541,-0.09224358,-0.09035285,-0.031266283,0.08192801,-0.059582923,-0.07871793,-0.027999325,-0.0072712223,-0.032781336,0.037136175,-0.012579823,-0.019095503,-0.03728241,-0.0070668217,0.017288757,-0.004883041,-0.04252879,-0.02384197,-0.101852775,0.087563895,0.004642385,-0.06582007,-0.041661188,-0.05208905,0.04847308,-0.021418592,0.16908787,-0.05759077 +1.1.4.1,"In the reverse reaction, vitamin K 2,3-epoxide is reduced to vitamin K and possibly to vitamin K hydroquinone by 1,4-dithiothreitol, which is oxidized to a disulfide; some other dithiols and 4-butanethiol can also act. Inhibited strongly by warfarin [cf. EC 1.1.4.2 vitamin-K-epoxide reductase (warfarin-insensitive)].",384,0.99999994,-0.031245245,0.039576884,-0.046602596,-0.009302551,0.064505406,0.0015706556,-0.040814366,0.011519066,0.029907832,0.06771149,0.02977019,0.023142343,-0.069838285,0.011352813,-0.06259469,0.042819414,-0.0044528083,0.11130449,-0.042265695,0.008685954,-0.06374251,-0.07994087,0.034802604,0.06947092,0.026668236,0.10621112,0.0024759402,0.07259182,-0.03538404,0.010321052,-0.013279501,-0.043407544,0.024086453,-0.055160943,-0.09141012,0.060369294,-0.031189252,0.018341258,-0.08235076,0.009329131,-0.015186011,-0.03313903,-0.08678446,-0.029974129,0.058276735,-0.008227295,-0.041513227,0.076207355,0.048280474,0.024456818,0.016076853,-0.058867656,-0.0827472,0.05735337,0.073815726,0.0007343419,-0.10436019,0.054806173,0.0044333665,0.05245284,0.040222727,-0.081107125,-0.0047904383,0.03974468,-0.01834928,-0.017415171,0.011881427,0.002842726,-0.019170985,-0.024833236,0.05459997,-0.066794634,0.06495345,-0.033097174,-0.0018183758,0.079943545,-0.07090701,-0.00832642,0.046899643,-0.051408514,0.048511423,0.0045391163,0.00516571,0.15702397,0.028800366,-0.037529744,-0.08865812,-0.0569877,0.05779608,0.046081945,0.01664175,0.0065864245,0.039417043,0.05305232,-0.027405405,0.07044428,0.040946275,0.027177982,-0.007276012,0.014544924,-0.034217387,0.035484634,-0.09666853,-0.0913152,-0.041011345,-0.018343356,-0.04875713,0.025966242,-0.05237914,-0.01213836,-0.01639801,0.00396372,-0.03952,0.0020927896,-0.014783049,0.034090973,0.1058734,-0.055875856,-0.104245186,0.0736696,-0.009432899,0.025544299,0.021376261,-0.027053863,-0.05098347,-0.029532751,0.103112556,2.3250134e-33,0.011409346,0.0664193,-0.027277233,-0.010753314,0.059002742,0.02658569,-0.068854704,0.0017328915,0.039291173,-0.06658141,-0.00040736844,-0.012315824,0.070494235,0.010746809,-0.05627909,-0.039715473,0.01759457,-0.013716181,0.028470643,0.028606348,0.088370375,-0.020631406,-0.095368974,0.03464175,-0.07028807,0.031164192,-0.055570804,0.03180011,0.02118734,0.02563691,-0.016572788,-0.08705388,0.0001912169,-0.033153787,-0.041124284,0.004012088,-0.116183914,-0.023715377,-0.012873784,0.08096495,-0.020602398,0.009635008,-0.10142135,0.005167397,0.03865819,-0.059821233,0.011478325,0.08391746,0.023918021,-0.01269887,0.07684305,0.059138373,0.020339759,-0.04012777,-0.03913602,0.08836989,0.08287572,-0.00836348,0.051393807,-0.038260244,-0.054340985,0.057792753,-0.04927421,0.0451466,-0.06245324,-0.03517477,-0.071203694,-0.0384831,-0.1265202,-0.023818657,0.012098703,0.048627462,0.059109636,-0.02982458,-0.013653179,-0.009550631,-0.017090693,0.031121839,-0.020988915,-0.021600656,-0.08063852,0.0028286548,0.02712249,0.050900314,-0.03975783,-0.019818213,-0.04030714,-0.04962723,0.037113417,-0.009303226,0.0490367,-0.033517476,-0.027389871,-0.084701926,0.09200024,-2.8888512e-33,0.059249677,-0.01564127,0.030513933,-0.008521454,-0.0013152823,0.12979986,-0.0061917272,0.01679586,0.044517245,0.01916854,0.078499414,-0.04743401,-0.042273372,0.03316999,0.005443228,0.07529043,0.0017765976,0.14044066,0.006309971,-0.059412386,0.06737264,0.001808098,0.05338523,0.08976597,0.016863933,0.021477753,0.005775371,0.013637893,0.037684754,0.10674416,0.01883272,-0.10074471,-0.048094936,-0.020572852,0.033259597,0.07758175,-0.06748237,-0.036095962,-0.044017,-0.026108067,0.033106606,-0.04416232,0.012599936,0.012233271,-0.011209179,0.043772593,-0.04369836,0.06708762,0.054294012,-0.08257089,0.046763197,0.06667588,-0.076124445,0.110925995,0.0320008,-0.017752599,0.029225234,-0.026426584,0.017260889,0.0038964336,-0.040482584,-0.13167234,0.035802193,0.03512436,0.024021106,0.036977656,0.011355164,0.08476677,0.057496626,-0.003610429,0.0134781785,-0.018514853,0.05894472,-0.04022376,-0.008861631,-0.04178673,-0.020639686,-0.049971614,-0.04769484,-0.039015695,0.025692064,-0.04880103,-0.008719457,-0.009179965,-0.06034739,-0.0635295,-0.044465914,0.12031755,-0.07628399,0.025178764,-1.8500414e-05,-0.00757806,-0.06930852,0.018291531,0.10261324,-3.6423994e-08,0.02609239,-0.05445,0.09421933,0.0086138155,-0.027681524,-0.027550764,-0.048999187,0.0791514,0.0503878,-0.08599315,0.07487406,0.07424765,0.05193076,0.018173024,-0.003211865,0.012159243,0.0341774,0.0453826,-0.016100205,-0.0592622,-0.039992455,-0.009432629,0.04400202,-0.06429947,0.007195046,-0.030402787,-0.014026968,-0.047019217,-0.012623475,-0.0919787,0.034042828,-0.008647888,-0.018900646,0.029537955,-0.078322396,0.05323655,-0.016598482,0.014065509,-0.06133731,0.020028593,-0.08328525,-0.03288187,-0.05536781,0.07679913,-0.007878209,-0.0186302,0.06335049,0.025775073,-0.04403268,-0.058344994,-0.009440669,0.013522132,0.023498917,-0.071930714,-0.081789464,0.044240657,-0.027287722,-0.045652,-0.013349811,-0.09449073,-0.040334385,-0.022673234,0.086649135,0.030527243 +1.1.4.2,"In the reverse reaction, vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.1.4.1 vitamin-K-epoxide reductase (warfarin-sensitive)].",384,1.0,-0.030438436,0.045917433,-0.0714724,0.0023116143,0.04466828,-0.0032046048,-0.038316645,0.024960253,0.034117304,0.075373486,0.03545693,0.019843392,-0.085752234,0.02026792,-0.074516155,0.026805628,0.019218417,0.1100819,-0.035952862,0.0046064886,-0.05664484,-0.082981974,0.048547897,0.05202791,0.013641381,0.119104266,0.0016243136,0.07462489,-0.035016667,0.012342436,-0.009342539,-0.039275568,0.044103175,-0.054866083,-0.069684215,0.052387845,-0.013799109,-0.006675533,-0.094567195,0.008554427,-0.01825863,-0.015232859,-0.06708503,-0.026712943,0.048460424,-0.013669442,-0.05880951,0.07649683,0.038169123,0.02934003,0.014291861,-0.055214882,-0.08260409,0.04995941,0.08101346,-0.010459795,-0.06940936,0.039521243,-0.0047114114,0.06909756,0.030441215,-0.10813236,0.0033121118,0.032827485,-0.0100540975,-0.057640575,0.016208926,0.009930627,-0.020706996,-0.0022586563,0.039330203,-0.04513648,0.07333014,-0.020712,-0.0019576582,0.08649269,-0.06830468,0.008192782,0.05335718,-0.054418065,0.048905637,0.013846045,0.0021685937,0.1559126,0.036189113,-0.04268339,-0.10688877,-0.047884975,0.053896826,0.05643229,0.018872345,-0.00020952294,0.052725617,0.0671952,-0.04327312,0.052918285,0.040325735,0.043561038,-0.036796957,0.011878987,-0.039069414,0.039518576,-0.095267765,-0.07355354,-0.024445815,-0.025363341,-0.04228629,0.07719933,-0.059703603,-0.0030732318,-0.00945079,0.019080106,-0.03588307,-0.0021476375,-0.018358372,0.0501858,0.09611213,-0.07233217,-0.08080783,0.07076341,0.0073233144,0.015623973,0.020740326,-0.014831272,-0.032270096,-0.045622483,0.09549115,-2.0775928e-34,0.021065721,0.06915013,-0.020806007,0.0032254593,0.032939225,0.026564797,-0.062471904,-0.035551682,0.05093518,-0.055685066,-0.014304956,-0.0054148333,0.07108561,0.030238623,-0.06684867,-0.05091661,0.0045716013,0.0050841435,0.024184544,0.015592341,0.10983194,-0.031877052,-0.08606884,0.01734623,-0.061297026,0.02363756,-0.0368053,0.03256621,0.03206222,0.025296176,-0.014012382,-0.07479646,0.013383669,-0.02935684,-0.01798235,0.008278386,-0.100994736,-0.023627438,-0.0007032071,0.0899434,8.764576e-05,0.0053069755,-0.086995825,-0.012134813,0.044755325,-0.08407245,0.025120506,0.067000024,0.015462509,-0.017215332,0.08072896,0.057156797,0.026307667,-0.039371185,-0.018142127,0.09573691,0.06917567,0.011254037,0.052428845,-0.029552523,-0.049652882,0.06676412,-0.07850838,0.055091627,-0.077951066,-0.013672585,-0.055582304,-0.0747366,-0.13705088,-0.006599319,0.01746619,0.04968034,0.08115667,-0.0148025425,-0.013446452,-0.020311736,-0.011483716,0.06003408,-0.007056373,-0.023461606,-0.07117371,0.024629308,-0.004395965,0.06462106,-0.060403276,-0.015930556,-0.028168948,-0.058665466,0.03034049,-0.014180911,0.038054712,-0.05482295,-0.005100116,-0.08129908,0.068916574,-5.543815e-34,0.0360981,0.002009295,0.0226301,-0.021008769,-0.023360804,0.13536252,0.0019975707,0.02848691,0.043739352,0.014544965,0.10052658,-0.037659936,-0.05329783,0.019382842,0.0065666405,0.07664998,-0.015089984,0.107435696,-0.006333256,-0.06975181,0.06354424,-0.025175584,0.069041885,0.0897053,0.021625664,0.022788702,0.020732313,0.026324717,0.03433288,0.08286617,0.00947885,-0.09371637,-0.054132484,-0.0033351087,0.01914225,0.07664659,-0.09847555,-0.03464196,-0.03044422,-0.008069413,0.010840525,-0.045685958,0.011060914,0.025544785,-0.021835266,0.048035722,-0.052282535,0.05981976,0.07690947,-0.093704544,0.008791231,0.070434585,-0.076887794,0.117842935,0.024753442,-0.017768675,0.017630136,-0.012448591,-0.0013646726,0.015197251,-0.033600967,-0.11698928,0.042010825,0.02821971,0.033463717,0.029481579,0.01417051,0.09374197,0.05066119,0.014111534,0.012548768,-0.019274306,0.0597111,-0.063722074,0.012435137,-0.062357087,-0.037195947,-0.04473424,-0.07786056,-0.028311776,0.026637632,-0.04289988,-0.01995896,-0.008687954,-0.045956545,-0.063792884,-0.04204444,0.11399942,-0.07134462,0.024650846,-0.006798655,-0.03568539,-0.06341579,-0.0016913045,0.07356918,-3.4506698e-08,0.018939909,-0.031206543,0.093563356,0.004372171,-0.04572826,-0.034831807,-0.06737497,0.07236044,0.034589812,-0.066482104,0.070788495,0.08620838,0.01781538,0.004478204,-0.026515586,0.0068521206,0.004817482,0.041825265,-0.0019477244,-0.058079462,-0.010636873,-0.008690587,0.045094036,-0.049325284,0.0121504115,0.0002504464,-0.0071326816,-0.07829575,-0.0032095693,-0.09351924,0.046477303,0.0047938693,-0.004645298,0.05518825,-0.09302279,0.042927593,-0.012361755,0.042547442,-0.07963706,0.030828834,-0.06852745,-0.017277118,-0.046902526,0.078173004,-0.013956424,0.0044543725,0.051743917,0.034871306,-0.045700904,-0.072947785,-0.012273619,0.030913958,-0.021018922,-0.07333789,-0.08583037,0.037766535,-0.038177736,-0.041506805,0.008139829,-0.06731643,-0.03576122,-0.020509532,0.070987426,0.03979204 +1.1.5.2,Integral membrane protein containing PQQ as a cofactor. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.,384,1.0,-0.05588408,-0.022924623,-0.076611355,-0.048150014,-0.019390717,0.002766942,0.043085054,0.02604293,0.038112722,-0.0060986755,0.008807479,0.0074706734,-0.083461225,0.08948451,-0.012359418,0.045180596,-0.053545035,-0.050261173,0.029593632,-0.050349742,0.07401709,-0.01819653,-0.023922253,-0.10833572,0.052474584,0.05346008,0.032248955,0.0416061,0.013398308,-0.07996163,-0.0183395,-0.028694943,0.023065096,-0.057364594,0.04126358,0.07365951,-0.056641728,-0.048293002,0.010634978,-0.060843732,0.07726436,0.009218062,0.041502196,0.028617024,0.040249765,0.0047462108,-0.05485681,0.13111626,0.039395563,-0.04195962,-0.032093264,-0.02978717,0.019886388,0.08006725,0.076439664,0.06520297,-0.013296861,0.013470445,-0.012498423,-0.043351483,0.018591683,0.06624413,0.027807372,0.024207857,-0.00818319,-0.08632356,0.03983922,-0.013062111,0.05249207,-0.020035688,-0.06145839,-0.060531463,-0.07995545,-0.06798907,-0.0032716638,0.071044594,-0.028880872,-0.049728625,-0.04799203,-0.005013344,0.04584656,-0.008242913,0.01937175,0.12724183,0.08327164,-0.019493772,0.002671631,-0.051597714,0.007521824,-0.009746318,-0.008632099,-0.054985452,-0.039955765,-0.0057851234,-0.07365541,0.051814985,0.085076146,0.032627862,-0.004971254,-0.03135013,0.0059901057,0.0064372914,8.527897e-05,-0.056875136,-0.081558816,0.07031996,0.019889858,0.11141876,0.017823601,-0.03531919,-0.022034975,0.01402156,0.05805273,0.0042376206,0.043700412,0.011255065,0.08819841,-0.03828083,0.007959878,-0.042994928,-0.03008861,0.010850064,0.0058066514,-0.0026952312,0.008520434,-0.0030948776,-0.13729179,4.891887e-33,0.033941217,0.008030052,0.040232804,-0.05257774,-0.025263328,-0.016970573,-0.025370624,0.011095384,-0.04436403,-0.028916921,-0.045057204,-0.048522633,0.033060305,0.0773056,-0.043942507,-0.016765818,-0.04535069,0.009102346,0.09416724,0.021740202,-0.028017476,0.017434508,-0.06793779,-0.009160318,0.1134035,0.03247499,-0.0059663975,0.020820756,0.01860824,-0.0019389441,0.055664547,-0.05662755,-0.09021507,0.031367064,-0.036738787,0.032023568,-0.08552296,0.0050775823,-0.072784066,-0.05633623,-0.014812265,-0.016561495,-0.030746477,-0.016870413,0.018151335,-0.05566734,-0.08010803,0.04042083,0.013382532,-0.0140489265,0.058931742,-0.013198549,0.0075577465,-0.038237445,-0.06583481,0.020990994,0.00653805,0.028140882,0.011979795,0.040328544,0.046654433,0.043415993,-0.15002511,0.0107524935,0.004080968,0.040084153,-0.023581363,-0.08663736,0.006951758,0.09035226,-0.10102564,-0.017800646,0.03792795,0.043877613,0.0175438,-0.0286208,-0.061603785,0.0029288023,0.057390273,0.016432304,0.01981688,-0.07540811,0.025434792,-0.004332772,-0.061804436,-0.076878645,0.02015736,-0.059380636,0.00016412202,-0.012645257,0.02574263,-0.051475614,-0.068009146,0.07204685,-0.024246372,-5.987173e-33,0.07945714,-0.08885507,0.09491631,-0.051318772,-0.01234593,0.054327518,0.008883668,-0.042897936,0.07584843,-0.093611725,0.049741615,0.020379663,-0.023212004,-0.02853998,0.042607024,0.01641227,-0.039112054,0.050020423,0.01294293,0.023818517,0.009467433,0.11312879,0.027808199,0.020887548,0.005380338,0.0017217107,0.027848396,-0.03483559,0.046193335,0.043656994,-0.030663418,-0.043633748,-0.035737697,-0.0646018,-0.08323158,0.016925724,-0.0813316,0.018717,0.036592912,0.02937598,0.038398556,0.0017577161,-0.008599295,0.034850553,0.04165477,0.10288352,-0.116735265,-0.00019806833,-0.04505665,0.001149217,0.091659315,0.040678494,0.018704265,0.05929391,0.0598036,0.08586657,0.035153434,-0.03067729,0.09086404,-0.039363578,-0.075655974,-0.027080718,0.009300811,-0.06423988,-0.0063215336,0.021312406,-0.0027655337,0.05094581,-0.020347705,-0.03960637,0.05910539,0.034517877,-0.031088261,0.04951492,-0.055480022,0.013262998,-0.11274379,-0.042491466,0.009193103,0.02499716,0.020174911,0.0062070275,-0.002540178,0.0031990048,0.04574199,-0.05860696,0.03277364,0.06541402,-0.0010166088,0.060385525,0.023163859,-0.005854236,-0.030712062,0.091810465,0.06414235,-4.3415596e-08,0.015380477,-0.031019218,0.017717239,-0.053042963,0.0012404778,0.021853635,0.045260932,0.026155064,0.05067894,0.03355308,0.03887136,0.08248312,-0.031535,-0.0010032161,0.01632241,0.0437286,-0.01615818,-0.040112495,-0.042393126,-0.048446264,-0.059862487,0.012847774,-0.1387764,-0.0066536358,0.022320941,-0.059346493,0.016922731,-0.022756612,-0.04744692,-0.005214403,-0.022514554,0.07070441,0.029093565,-0.029499631,-0.057835784,0.004685454,0.012468445,-0.14409284,-0.018137937,0.003332074,0.03790373,-0.06885796,-0.01835753,-0.033110242,0.027357142,0.03061208,-0.03900815,-0.013514953,-0.08453981,0.054958776,0.10348849,-0.03180217,0.000274015,-0.08028624,-0.14485276,0.07179946,-0.013994394,-0.03804582,0.011543462,-0.097160414,0.055278864,-0.0031885854,0.23375654,0.026904793 +1.1.99.1,"A quinoprotein. In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyse the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. In plants, the first reaction is catalysed by EC 1.14.15.7, choline monooxygenase, whereas in animals and many bacteria, it is catalysed by either membrane-bound choline dehydrogenase (EC 1.1.99.1) or soluble choline oxidase (EC 1.1.3.17) [4]. The enzyme involved in the second step, EC 1.2.1.8, betaine-aldehyde dehydrogenase, appears to be the same in plants, animals and 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+1.1.99.4,A flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.1.99.6,"The zinc flavoprotein (FAD) from the archaeon Archaeoglobus fulgidus cannot utilize NAD+, cytochrome c, methylene blue or dimethylnaphthoquinone as acceptors. In vitro it is active with artificial electron acceptors such as 2,6-dichlorophenolindophenol, but the physiological acceptor is not yet known.",384,0.99999994,-0.1069134,0.00724851,-0.06949667,-0.016108574,0.06848262,-0.040060703,-0.018322596,0.051538907,0.010592438,-0.012117018,-0.009605821,0.011646147,-0.03348226,0.016822826,-0.09830387,0.067524076,-0.030907098,0.008756898,-0.023891406,0.07612901,-0.029504588,-4.8705446e-05,0.036162168,-0.07597633,-0.032110885,-0.03542942,-0.06329336,-0.022440156,-0.007214425,0.0043070517,0.010775552,0.07759891,0.05662786,0.019249031,-0.06207421,0.018042417,0.0024898797,-0.017054027,-0.030727424,0.04091241,0.025656246,0.017440267,0.016962113,-0.050994795,-0.008208296,-0.02782529,0.0118664075,0.024149675,-0.00010186014,0.045148175,-0.02497269,-0.02917292,-0.058014877,0.0756299,-0.021970706,0.103959106,-0.0043011243,-0.084889404,-0.014030077,-0.035450403,-0.02204607,-0.0130598685,-0.014101006,-0.0054194154,0.02518541,-0.036219344,-0.07684322,-0.05877076,0.05017465,-0.07274442,0.03545261,-0.0048689004,-0.006834565,-0.012797452,0.0051357136,0.14653432,-0.036651522,-0.038842477,0.08717083,-0.057753995,0.027383847,-0.08555675,0.07331904,0.09997249,0.112288214,0.045209236,-0.055104654,0.06517352,-0.08106833,0.0863755,0.046829112,0.01844327,-0.012512627,-0.025742326,-0.10662164,0.059940092,0.049977757,-0.01191157,-0.06696405,0.0038091596,0.02014748,0.0031327428,0.03810767,-0.10146477,-0.07504063,-0.053859305,-0.023180628,0.05851929,-0.010384501,-0.047342982,-0.023246106,-0.08219108,0.084741496,-0.02979989,-0.016197108,0.047828265,-0.017506449,-0.091735624,-0.0469869,-0.07371862,-0.07112647,0.046916097,0.057251185,0.023626784,0.031469364,0.035069376,-0.072663546,7.662297e-33,0.045624252,0.043721188,-0.030162664,-0.0141587155,-0.00890063,0.06003398,-0.054870088,0.0073283394,0.023413265,-0.1044133,-0.06325297,0.0006287932,0.030772517,-0.03539116,0.010619628,0.049342062,-0.04299524,-0.05863209,0.08138877,-0.07284742,0.09584601,0.015066219,-0.02421159,-0.020729197,0.04975842,-0.010992156,-0.094991796,0.05279554,-0.019290369,0.044586875,0.048281718,-0.094563216,-0.0649992,-0.0065231505,0.028038045,0.067899644,-0.022246132,-0.075806335,-0.13876034,-0.04298889,-0.0023102972,-0.008390161,-0.07022374,0.070671275,0.047681876,-0.002205395,-0.055013202,0.044432368,0.010594244,0.08774314,0.0148595255,0.0048012477,0.031312708,-0.0044907923,-0.07422543,0.03985064,0.0070699616,0.012053265,0.006088154,0.015490715,-0.004797948,0.08009631,-0.011593028,0.102064855,-0.02452358,0.02492641,-0.04961111,-0.060079444,-0.048797145,0.08482789,0.049796678,-0.039426584,0.021792952,0.010508926,0.013218991,-0.05552969,0.011372031,-0.07654171,0.00495012,-0.019206073,-0.007866123,-0.088390425,-0.034747466,0.02618475,-0.033305094,0.04532246,0.04999554,-0.006918687,0.04352919,0.011211626,0.06544529,-0.07184679,-0.0134856235,-0.008064723,0.022604948,-6.820991e-33,0.004535232,-0.071061544,0.021091796,0.0016119119,0.019837378,0.044889826,0.027389724,-0.03088831,0.09492118,-0.089998044,0.08554286,0.0046468256,0.03450762,0.039041378,0.037669737,-0.03146446,-0.073173285,0.041025877,0.0639627,0.0457742,-0.04252692,-0.013917052,0.0350616,0.116447315,0.020885183,0.0134514915,-0.0039010271,-0.06750214,0.0037164348,0.0379996,-0.04886341,0.11487148,-0.033590242,-0.049775496,-0.022048242,-0.036165748,-0.015491348,-0.0047089173,0.0139700435,0.032802075,-0.021881811,-0.004568722,-0.06390087,0.01098435,0.02938133,0.03784345,-0.062249936,0.011703925,0.05614328,-0.016138159,0.044623397,0.04390874,0.003138898,0.021693122,0.12743193,0.043302324,0.07021937,0.027456772,0.015854012,0.011524574,-0.027483819,-0.0972921,0.023613218,-0.03495787,0.09447312,0.08013413,0.048769042,0.19318026,-0.05784286,-0.021013772,0.13263512,0.041045826,0.047193944,0.09021605,0.05513385,-0.023434132,1.5438525e-05,0.07577304,0.005443105,0.004728448,-0.0055218623,0.025782106,0.041595675,0.007091557,-0.043403726,-0.10329441,-0.020414745,0.024847211,-0.06298734,-0.037399236,-0.038005687,0.052225504,0.014320134,-0.04258354,0.033119723,-4.2269654e-08,-0.015454011,0.032376934,0.031566504,-0.059489004,0.018654576,-0.022540543,-0.010030768,-0.04852412,-0.02442026,-0.04040175,-0.011428831,0.15401442,0.037204012,0.021612713,0.058432557,-0.02735203,-0.02987506,-0.0374485,-0.033346787,-0.01278608,-0.05054995,0.054979622,-0.062355474,0.02511869,-0.023688843,-0.015250651,0.013870652,-0.04834989,0.047944766,-0.027005212,-0.011017181,-0.007884723,0.021349609,-0.033920005,-0.05921613,0.057407554,0.005459046,-0.081280254,-0.0804838,0.023916427,-0.040638797,-0.056191348,-0.01133436,-0.05122483,-0.006785102,-0.05542028,0.09542371,0.018619329,-0.045182798,0.024022067,-0.014092045,-0.02623383,0.052208837,-0.07187496,-0.039618686,-0.048016854,-0.014436307,-0.04433249,-0.031385116,-0.088845946,0.028168032,0.0132923275,0.117343515,0.018611481 +1.1.99.7,Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This cofactor cannot be removed without denaturation of the protein.,384,1.0,7.133732e-05,0.0066308985,-0.09530405,-0.060983688,0.074176185,0.0841082,-0.045129392,-0.016388698,0.0040934687,-0.02816547,0.0070125563,-0.041889574,-0.10945819,-0.038085695,-0.00439831,0.023902705,-0.027544111,0.060505517,0.025537381,-0.053582788,0.021593513,-0.067636944,0.0006203246,-0.00392958,-0.04677964,0.11681669,-0.013511063,-0.034549817,0.008735843,-0.06318121,-0.002955607,-0.060994793,-0.03584755,-0.044122346,0.013467433,-0.0057301754,-0.026986204,-0.06321696,0.021172034,0.031893853,0.06987127,0.04793269,-0.014033679,0.049943775,-0.061285883,0.047390964,0.04598068,0.029494608,-0.006784656,-0.05988072,-0.04075665,-0.0245292,-0.076034054,-0.0095296325,-0.07975637,0.053047147,-0.046592917,7.1101524e-05,0.0500601,0.001833254,0.041865483,0.012174087,0.058195714,0.025423735,0.065688096,-0.13953145,0.04752808,-0.041311968,0.015940038,0.0026978957,-0.069911055,-0.06069485,0.00415902,-0.013359784,0.037727643,0.027061526,-0.070903145,-0.067214936,0.1238706,0.021932468,0.04146668,0.00093328627,-0.005174216,0.1451393,0.011703698,0.032004606,-0.010632424,-0.050230913,0.02055119,-0.025343318,0.00074130815,-0.018263295,0.01562936,-0.0013439364,-0.13936226,0.004403717,0.09180916,0.06905065,0.012798032,-0.003980073,0.013504908,0.14547949,-0.01583105,-0.089132585,-0.061644975,0.058292035,-0.036478173,0.12483425,0.02907448,0.04097045,-0.02574484,0.040640566,-0.006228073,-0.037285794,-0.018076278,0.09328629,0.030177489,-0.03352277,-0.07127363,-0.07270457,-0.0029120117,-0.057152964,0.029213889,-0.027165998,-0.025135463,-0.021646578,-0.09172775,2.7970139e-33,0.020623846,0.046657417,0.024793986,0.030331431,-0.071771875,-0.038051207,-0.056007672,-0.014823418,-0.002698088,-0.012556626,-0.050395064,-0.08032994,0.047800004,0.050831605,-0.04200635,-0.048203904,0.008788315,-0.03488092,0.020770129,-0.011282004,0.028822655,0.09980013,0.027303064,0.012304424,0.037808396,0.037242908,-0.049682017,-0.05465614,0.059083935,0.007892495,0.008057546,0.023602808,-0.09585159,-0.005056489,0.044026423,0.0011529106,-0.030642027,-0.062548146,0.023426907,0.03252464,0.0011513681,0.00024155904,0.009106833,-0.07504916,0.04188928,-0.08150989,-0.040073756,0.014682821,0.0015342878,0.019918958,0.013452418,-0.1059415,0.07621468,-0.03373696,-0.04651967,-0.033558965,0.01829316,-0.040771574,-0.029027687,0.04736209,-0.07461684,0.031380128,-0.03236716,0.03963191,0.017413057,-0.021899117,-0.09490923,-0.08837095,0.037891656,0.01834851,-0.040205322,0.02663221,0.077643484,-0.0123406835,-0.019879045,-0.050654393,0.0015851378,-0.025220165,0.03377376,0.06540563,0.0019295542,-0.03388285,0.076706804,0.013944264,0.057483863,-0.09136421,-0.011425185,-0.036103662,-0.028205357,0.07694796,0.004509324,-0.055720706,0.036029443,-0.012775837,0.0059671868,-4.2574378e-33,0.0686145,-0.06671511,0.023390463,-0.09992659,-0.06219092,0.056529626,0.0847371,-0.034513306,0.013755819,-0.024999775,0.01399642,-0.0066825664,0.10637568,-0.056449622,0.02484621,-0.011901961,0.011733188,0.042108983,-0.062027097,-0.015034302,0.05656653,0.045622412,0.0051100045,0.07437508,0.064377,-0.017322604,-0.019867187,-0.0022962273,0.06883112,0.046639945,0.017197806,-0.02777999,0.016785314,-0.029971544,0.017151996,0.028999435,-0.019118613,0.075363934,-0.019008256,0.049017873,0.014295643,-0.020804696,-0.007418939,0.05655573,0.08454169,0.043838188,-0.100976296,0.03795681,-0.0074808244,0.043317754,0.055994224,-0.020817712,-0.104422234,0.015838532,0.086688094,0.07403927,-0.01935609,-0.024054367,0.022865089,-0.026894508,-0.06923953,-0.029507712,-0.060964517,-0.04246818,0.06704002,0.022526758,0.022136936,0.025805678,0.05074549,-0.10008796,0.08522786,0.105888546,0.06345096,-0.002611054,0.05072846,-0.07091727,-0.07997571,-0.056614317,0.027793841,-0.032586824,-0.02335052,0.013477243,0.08362514,-0.061766695,0.08635455,-0.018862715,-0.023481803,0.023598336,-0.04255827,-0.029975154,0.021884644,-0.04440199,0.05386473,0.05625034,0.015633216,-3.6120596e-08,0.04377733,-0.034575157,0.09327378,-0.023178168,-0.052616972,0.12321353,-0.028209725,0.011748547,0.06526929,-0.036334343,-0.0026039928,0.10464064,0.024769038,0.012156765,0.015972951,-0.0024328264,-0.029087447,0.01019501,-0.057537094,-0.039747514,-0.0967849,-0.0065700435,-0.07212189,0.046078417,-0.01337686,-0.03654949,0.02894036,0.0054128347,-0.017914617,-0.028090004,0.07014495,0.004587364,0.07120782,0.02222449,-0.026365265,-0.06390334,0.06145975,-0.017600592,-0.054033693,-0.011623767,0.021723919,0.0400977,-0.09555809,0.0275352,0.027565073,0.00114255,-0.05272465,0.05719338,-0.062108785,0.03908587,0.07456214,-0.013209842,-0.05638147,-0.057004463,-0.0769689,-0.084970415,0.005693988,-0.012789422,0.014593164,-0.089788534,0.04546457,0.037024867,0.17002432,0.015307983 +1.1.99.8,"A quinoprotein. Acts on a wide range of primary alcohols, including methanol [cf. EC 1.1.99.20 alkan-1-ol dehydrogenase (acceptor)].",384,1.0,-0.042167887,-0.02936562,-0.07919554,-0.02898147,0.08301631,0.007250581,0.027029442,0.040530227,0.038970467,-0.027097793,0.009646805,-0.056024056,-0.14245209,0.057546012,-0.0069094175,0.11677392,-0.0045499015,-0.059573006,0.039619353,-0.032388996,-0.03149322,0.031438258,-0.013961845,-0.034564696,0.01595311,-0.00378292,0.026362684,0.071013644,-0.0323984,-0.028850768,0.019163022,0.022643656,0.06200718,-0.0077813417,0.017572531,0.07358222,-0.020650057,-0.010473765,0.05854425,0.019099409,0.06387228,0.0132470885,0.03565516,0.02723211,-0.011556027,0.014265661,-0.055328343,0.1346935,0.006054799,0.0024098565,-0.050087705,-0.04296489,0.047611568,0.08135604,0.10412383,0.03333122,-0.061355952,0.014384089,-0.016169215,0.0818503,-0.010666413,0.020633895,-0.012612933,0.021781547,0.045901876,-0.05439409,0.037382513,-0.017303223,0.054748427,0.02004631,-0.009383264,-0.032580283,0.05710667,-0.053002343,-0.07242542,-0.08782168,-0.053877912,-0.019239588,0.051743954,-0.012918398,-0.03259602,0.050692525,0.041573856,0.027991625,0.060024936,-0.058434464,-0.010570965,-0.005526683,-0.016854819,0.043259524,-0.02425399,-0.07709893,-0.009696449,-0.11141212,0.00010465178,0.054907855,0.07380679,-0.064645655,0.01511226,0.02477552,-0.025573522,0.0322646,-0.033532042,-0.10539393,-0.10481485,0.040451545,0.02804473,0.030452965,-0.014418674,0.065220974,-0.0108071305,-0.07231006,0.09956506,-0.0073137525,-0.015400514,0.030244933,0.019290777,-0.08454052,0.027314615,-0.07429796,-0.03662334,0.02159382,0.076350294,0.048784412,-0.0038121017,0.023450691,-0.014908637,-1.7616012e-33,0.044411793,-0.056383446,-0.055534,0.0415226,-0.00021259372,-0.035589702,-0.029143197,0.032675497,-0.0661459,-0.052245103,-0.05211512,-0.011374502,0.056037422,0.018600447,0.0041850307,0.0043414496,0.034977827,-0.016454445,0.062361147,-0.03885434,-0.050633464,0.027621454,-0.114444025,-0.0043994915,-0.05763323,0.047510892,-0.015649978,0.028725322,0.057062563,-0.0036711304,-0.016366506,0.04395167,-0.016944954,0.06942215,-0.037794016,0.050454408,-0.091334864,-0.010314168,-0.05020929,0.031632423,0.029288908,0.055349614,0.018841581,-0.036509383,0.009207481,0.04005847,-0.057851452,0.059672844,-0.0057236836,0.012199144,0.02808168,-0.04517025,0.010094722,-0.104568735,-0.13599141,0.01988029,-0.02999337,0.00081838906,0.051188614,0.03075069,-0.09917805,0.022368452,-0.07500947,-0.007450984,-0.03768752,-0.0015022111,-0.07455478,-0.13105555,0.056634776,0.0689696,-0.057877146,0.04515607,0.08457876,0.007660925,-0.031575177,0.01638223,0.032555357,-0.012790901,0.022939304,0.08981943,0.020997005,-0.014330973,0.031222666,-0.024115479,0.013262576,-0.066312574,-0.04194509,-0.09272858,0.017659094,0.027503284,-0.04058844,-0.05274404,-0.022111159,0.04857076,0.064219296,-2.2450666e-35,0.07944956,-0.11523651,0.06686341,-0.014110109,-0.011129265,0.14781684,0.009179159,-0.06869676,0.034802508,-0.0067629945,0.09368221,-0.04579761,0.04250732,-0.019739524,0.046931088,-0.0035632912,-0.061882455,0.0739881,-0.006513115,0.018544018,-0.0022620978,0.08249406,0.025451198,-0.0031294285,0.04620829,0.026222356,-0.050040808,-0.0058781924,0.010117818,0.079850085,-0.025278596,-0.047932,-0.03818313,-0.010125418,-0.0081870565,0.06533138,-0.06820795,-0.019905468,-0.07966964,0.01657801,0.006355195,0.03409949,0.015981693,0.051353592,0.022874143,0.05611506,-0.07346505,-0.016232438,-0.073242694,-0.0732981,0.018784907,0.005223223,-0.0760804,0.020477792,0.057002857,0.11132692,0.0018143965,-0.04873394,0.022901604,-0.03350919,-0.06343248,-0.056025866,0.03834281,0.00096578803,0.00603504,0.018765964,-0.053041033,0.11527423,0.009161388,-0.026329868,0.08211572,0.027189888,0.050802372,0.055374246,-0.046561144,-0.09266939,-0.08022134,-0.043678347,-0.017863419,0.05007322,0.024788054,0.02229945,-0.04783825,0.02914475,-0.003499829,-0.074804544,0.08567028,0.071319565,-0.013719884,0.06201204,0.020778628,0.050268944,-0.11079463,0.059038926,0.023030948,-3.391776e-08,-0.017143106,-0.023528382,0.036802817,0.03973882,-0.015694628,0.006672587,0.07766682,0.0029292807,-0.010112245,0.0048520397,0.014949205,0.07048872,-0.004941721,-0.010663874,0.047900636,-0.0086318785,-0.050398376,-0.03952033,-0.032369815,0.02639572,-0.01975729,0.0018119499,-0.017027041,-0.03400184,-0.07911509,-0.06612366,0.022007912,0.05584698,-0.05353626,-0.025228214,-0.06250902,0.0740639,-0.047238883,0.0015675548,-0.040207516,0.01879294,-0.013891924,-0.008012229,-0.08440974,0.03161058,0.03429337,-0.078448296,-0.09997548,0.0058893138,-0.0014527445,-0.021691617,-0.014176311,0.005481225,-0.041851822,0.03468426,0.07514589,0.056790795,0.08713845,0.026986634,-0.045725342,-0.011689038,-0.06059401,-0.057824273,-0.08931906,-0.06278157,0.11185633,-0.015893422,0.17729455,0.058410227 +1.1.99.9,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.1.99.10,"A glycoprotein containing one mole of FAD per mole of enzyme. 2,6-Dichloroindophenol can act as acceptor",384,0.99999994,-0.045298696,-0.08783152,-0.03902627,-0.014284079,0.07225333,0.004097409,0.048917,0.106630005,0.05206411,-0.04285386,0.03218423,0.009525368,-0.12696755,0.011093181,-0.05204972,0.083563186,-0.061279856,0.04186761,-0.09747697,0.008886429,0.003171608,-0.026714193,-0.06653121,-0.008153119,0.003113534,0.03491636,0.036077507,-0.041256353,-0.012684431,-0.010558404,-0.0070619704,-0.0040381835,0.03877979,0.070262246,-0.005799958,0.067255676,-0.005697185,-0.05856722,-0.022432078,0.020113073,-0.008037753,-0.0022804884,-0.052640688,-0.038424723,-0.033637147,-0.04607752,-0.01822327,0.07546937,0.05853254,0.011120904,0.020495532,-0.021281622,-0.054180577,0.04431329,-0.035349723,0.07406398,-0.029586785,0.013615488,-0.03675375,0.051198095,-0.02377399,-0.00044800848,-0.002151676,0.019661438,0.0058554816,-0.04709311,0.03381308,-0.04812685,0.011094707,0.0024418584,-0.0036137626,-0.021069681,0.02221256,-0.083348855,0.0058441693,0.030089393,-0.036767546,0.0026984613,0.10976216,-0.07189619,0.03271577,-0.009554478,0.1059432,0.0771899,0.01158496,-0.039752234,0.034102503,0.041182023,-0.024691762,0.053828266,0.011507633,-0.024884753,0.003859927,-0.07697868,-0.052574623,0.04149613,0.030660577,-0.07253949,-0.011865503,0.019137269,0.024601871,0.027785962,-0.010006878,-0.06965197,-0.10796434,0.050353006,-0.0839411,0.018024236,0.010382147,0.022759333,-0.012734757,0.005924142,0.091243975,0.02428857,-0.0123461755,0.0049652746,0.025285512,-0.075961016,0.0230281,-0.014269984,0.0088056,0.019418756,0.08051416,0.045196746,-0.05822168,0.07923982,0.0009874164,3.947278e-33,0.022630598,0.033620995,0.022553781,0.017190685,-0.06369743,0.05988944,-0.07927388,0.078979045,-0.034421045,-0.098576546,-0.03702823,-0.03850782,0.0050403327,0.037800413,0.05893149,-0.0021572737,0.038362827,0.033996895,0.09090987,-0.08934471,0.010074853,0.04324001,-0.04721055,-0.027583284,0.022803916,0.053522956,-0.09076312,0.060450673,0.069689505,0.015778894,-0.002157824,-0.09540761,0.028978974,0.08525712,-0.0310694,0.04130367,-0.023338376,-0.07124116,0.033237774,0.00087817194,0.020644087,-0.03967202,-0.023851313,-0.023526845,0.052628826,0.012480356,-0.033283114,-0.034082446,-0.022902409,0.09237661,-0.07036573,-0.043390464,0.01466679,-0.060934182,-0.03876842,0.020388173,-0.053587276,0.018829472,0.015749214,0.034966756,-0.024360599,0.15221219,-0.045522485,0.03740131,-0.009349262,-0.01239474,-0.066503495,-0.027480517,-0.04907389,0.1059721,-0.05312746,-0.029796286,0.062589,0.04340498,0.008600999,-0.12489231,0.06005532,-0.021150818,-0.016998852,0.055589393,-0.068784215,0.0032683762,0.01677648,-0.0264976,-0.09838282,0.05037359,-0.0032281694,-0.117467515,-0.01368981,0.019848319,0.020803783,-0.07430981,-0.09754172,0.0385905,0.0013709537,-5.5254196e-33,0.06549786,-0.16430861,0.11467222,0.039958227,0.030219605,0.07147376,-0.0043543074,-0.045330416,0.06324883,-0.007624774,0.04189277,-0.010319509,0.032442655,-0.05557038,0.016031764,0.00991491,-0.00017622598,0.08399149,0.0013180934,0.07072564,0.012856676,-0.006390405,0.028021064,0.07372933,0.017455839,-0.022809353,0.021872787,-0.07029965,0.054183424,0.036438655,-0.016220983,0.07509178,-0.029377362,-0.013564149,0.0035374537,-0.034174383,-0.06517936,-0.0480354,-0.041200362,0.033508718,-0.046886094,0.030187577,-0.0050498554,0.008659756,0.045406327,0.018412936,-0.0005672609,-0.036237143,0.0008535046,-0.082641035,-0.0042469744,0.0008300115,-0.076121666,0.054871112,0.030970609,0.018182993,0.057229858,-0.041359596,-0.020776324,-0.0035506387,-0.018343817,-0.086257726,-0.0025019252,0.037019543,0.04835431,0.016769612,-0.027194098,0.17027844,0.036223058,0.0046921405,0.096663795,-0.02393065,0.06676093,0.07387047,0.009264626,-0.043734122,-0.06398203,-0.027452728,0.023989102,-0.016956093,-0.008093236,0.06669009,-0.04396491,-0.009267373,0.0059841857,-0.12811226,0.03822633,0.119268306,-0.075202115,0.050888103,-0.036071572,0.02618148,-0.067502156,0.05514402,0.09615758,-3.369177e-08,0.039431233,-0.119171545,0.07159939,-0.07692026,0.007026901,0.031108832,0.017306112,0.002237735,-0.048139803,0.018534163,-0.04080516,0.049482625,-0.02957894,-0.05488571,-0.05691628,0.057864826,-0.09314027,-0.03911579,-0.017761867,0.02305148,-0.042276796,0.045794424,-0.08310805,-0.024758672,0.017813213,-0.040266167,-0.016111342,0.07459581,-0.060939606,0.030459538,0.010847672,-0.008107071,-0.093447745,-0.03596618,0.006108019,0.0075484687,0.057735626,-0.049751837,-0.112596646,0.066293254,0.034086905,-0.039839458,-0.012604869,0.008701206,-0.013236311,0.0028386023,0.0147149805,-0.04085891,-0.00619253,0.019094823,0.014391592,-0.026506275,-0.004045829,-0.045815296,-0.096681885,-0.024784762,-0.012602772,-0.05355049,-0.07287618,-0.05658422,-0.0055603622,0.03849011,0.15460089,0.021846408 +1.1.99.11,"2,6-Dichloroindophenol can act as acceptor.",384,0.99999994,-0.03614478,-0.06543463,-0.00856264,-0.008087722,0.03341123,-0.02987315,0.054682262,0.085421905,0.06166296,-0.024883268,0.025996024,-0.026770752,-0.09549935,0.011748703,0.0049347347,0.113022484,-0.08555628,0.05657743,-0.11225858,0.067967266,-0.0017773572,-0.019396676,-0.009229128,-0.013747652,-0.0363502,0.051953446,0.017846726,0.010151282,0.019399306,-0.045995932,0.02640977,0.07909167,-0.005375359,0.060236618,-0.0142957475,-0.006446086,-0.021751301,-0.02708202,0.016904883,0.050409053,0.0108533725,-0.039443877,0.008189939,-0.0314399,-0.014137127,-0.04118002,-0.05607425,0.08758568,0.06416521,-0.096921824,0.05474927,0.039558046,-0.058518365,0.09043524,-0.055875283,0.059408773,-0.0964101,0.0020644597,-0.020087458,0.026140837,-0.022978578,-0.0010787199,-0.014100438,0.018025706,0.0049212584,0.00068961503,-0.030788023,-0.06236318,0.0044588344,0.011845476,-0.002807454,0.018643761,0.0468577,-0.061106075,0.031000191,0.023485932,-0.012081282,-0.025560714,0.04358201,-0.07290393,-0.03848742,-0.01884882,0.076375306,0.07164669,0.048507746,-0.052016485,-0.040871926,0.02587449,-0.036142398,0.09256923,0.010283763,0.027437223,0.053651012,-0.07695271,-0.060129575,0.041233048,0.006014745,-0.0058937115,-0.019598626,0.044025786,0.009464786,0.02656474,-0.09740788,-0.046810333,0.0067912573,0.009281411,-0.040659066,-0.02601761,-0.009907864,-0.04064614,0.0009384936,-0.0672118,0.08736101,0.04503722,-0.02001761,0.05503576,0.020713544,-0.04314938,0.03502988,-0.037080154,-0.013230142,0.004888642,0.033192728,-0.018727368,-0.10081155,0.038726907,0.036647767,2.3964748e-33,-0.02658298,0.028308058,0.05398162,0.050817367,-0.037742734,0.083328314,-0.09022775,0.004999934,-0.006196813,-0.13850373,-0.05487986,-0.03459978,0.01709796,0.06692161,0.045927767,-0.015540194,0.009824072,0.10617994,0.085162476,-0.042147163,0.0009958156,0.052195072,-0.095306985,-0.019700216,-0.025922215,0.08880447,-0.037695546,0.02213279,0.06289746,0.006718867,0.018623956,0.006330158,0.04989195,0.10461078,-0.07925012,0.040361326,-0.0010198678,0.0033013343,0.022172505,-0.08632709,0.0037323944,0.016259028,-0.08132922,0.045080293,0.060670037,-0.019455852,0.039766666,-0.069309615,-0.014948953,0.056834884,-0.08063016,0.011437038,0.028799707,-0.04883447,0.03756883,-0.0284423,0.018784607,0.045397747,0.028710263,0.03098261,-0.017697359,0.1301311,-0.023933312,0.0150139555,0.007862518,0.021843106,-0.08263287,-0.05790276,-0.071674146,0.081759974,-0.061623517,0.00028989077,-0.00429972,0.07398245,0.052711528,-0.062615246,0.044326197,-0.018966014,0.010013472,0.017929688,-0.054666623,-0.038698085,0.061628927,0.044028085,-0.1248279,0.04388351,0.00510678,-0.09559357,0.0116145555,-0.012280173,0.09239226,-0.07773372,-0.08163579,-0.0152325,0.030940445,-2.4188134e-33,-0.00713523,-0.049054045,0.0072211227,0.06977833,0.051685777,0.04660254,-0.013306877,-0.05215865,0.08441521,-0.013037303,0.09852614,0.045727916,0.044683527,-0.04402793,0.017521612,-0.004299961,0.017200653,0.09641324,0.012229938,0.021442961,0.00962903,0.0035994763,-0.055018943,0.09841105,-0.013557503,0.0574447,0.032404583,-0.1341151,0.0657858,0.040500525,-0.042524505,0.056149084,0.021599224,0.019664917,0.05440213,-0.048956085,-0.06698395,-0.048113547,-0.10003176,0.030721756,-0.048757266,-0.05883463,0.00049635046,0.040485036,0.009620498,-0.025473345,0.06278836,-0.00674737,-0.020964105,-0.039864648,0.0019569546,-0.006473223,-0.07526595,0.0401941,0.064720415,0.0067298575,0.06161766,-0.10802856,0.009209378,0.0018927148,-0.011198986,-0.030291911,0.014535976,-0.024240268,0.019526388,0.008091847,-0.04197004,0.16889769,0.014076126,-0.060128726,0.11420963,-0.038866393,0.07358026,0.01376622,0.014056959,-0.0933703,0.0066207508,-0.048877716,0.02052873,-0.014154595,-0.14048357,0.034451827,0.006740161,-0.018722668,0.0029125386,-0.12483823,0.038679767,-0.016125608,-0.09088734,0.081772245,-0.0096713845,0.054872423,-0.028009627,0.053527415,0.050523713,-2.456695e-08,0.018686337,-0.13104752,0.06313249,-0.036367677,-0.038186986,-0.007996794,0.054440692,0.054963414,-0.050359577,0.014374598,0.004373937,0.04862751,0.050978266,-0.012532271,0.016564347,0.025473785,0.0026589145,-0.057417512,-0.059735186,-0.0183622,-0.039882675,-0.002357222,-0.014776658,-0.0964039,0.015141316,-0.006830881,-0.016066335,0.038831815,0.021046907,-0.0020329652,0.045308746,-0.044189833,-0.07613705,-0.007228481,0.032301523,0.065721855,-0.0067729987,-0.08970335,-0.08217246,0.046115313,0.009273355,-0.07328054,-0.072581045,0.052059777,0.02560578,0.0030005565,-0.0034203054,-0.0349855,-0.03630466,0.00032528015,-0.00060237345,0.002999674,0.0459246,-0.0029709472,-0.0652245,0.02972571,0.0023304422,-0.027462298,-0.019837603,-0.059635945,0.015316194,0.015583357,0.12521887,0.03272991 +1.1.99.12,"2,6-Dichloroindophenol can act as acceptor.",384,0.99999994,-0.03614478,-0.06543463,-0.00856264,-0.008087722,0.03341123,-0.02987315,0.054682262,0.085421905,0.06166296,-0.024883268,0.025996024,-0.026770752,-0.09549935,0.011748703,0.0049347347,0.113022484,-0.08555628,0.05657743,-0.11225858,0.067967266,-0.0017773572,-0.019396676,-0.009229128,-0.013747652,-0.0363502,0.051953446,0.017846726,0.010151282,0.019399306,-0.045995932,0.02640977,0.07909167,-0.005375359,0.060236618,-0.0142957475,-0.006446086,-0.021751301,-0.02708202,0.016904883,0.050409053,0.0108533725,-0.039443877,0.008189939,-0.0314399,-0.014137127,-0.04118002,-0.05607425,0.08758568,0.06416521,-0.096921824,0.05474927,0.039558046,-0.058518365,0.09043524,-0.055875283,0.059408773,-0.0964101,0.0020644597,-0.020087458,0.026140837,-0.022978578,-0.0010787199,-0.014100438,0.018025706,0.0049212584,0.00068961503,-0.030788023,-0.06236318,0.0044588344,0.011845476,-0.002807454,0.018643761,0.0468577,-0.061106075,0.031000191,0.023485932,-0.012081282,-0.025560714,0.04358201,-0.07290393,-0.03848742,-0.01884882,0.076375306,0.07164669,0.048507746,-0.052016485,-0.040871926,0.02587449,-0.036142398,0.09256923,0.010283763,0.027437223,0.053651012,-0.07695271,-0.060129575,0.041233048,0.006014745,-0.0058937115,-0.019598626,0.044025786,0.009464786,0.02656474,-0.09740788,-0.046810333,0.0067912573,0.009281411,-0.040659066,-0.02601761,-0.009907864,-0.04064614,0.0009384936,-0.0672118,0.08736101,0.04503722,-0.02001761,0.05503576,0.020713544,-0.04314938,0.03502988,-0.037080154,-0.013230142,0.004888642,0.033192728,-0.018727368,-0.10081155,0.038726907,0.036647767,2.3964748e-33,-0.02658298,0.028308058,0.05398162,0.050817367,-0.037742734,0.083328314,-0.09022775,0.004999934,-0.006196813,-0.13850373,-0.05487986,-0.03459978,0.01709796,0.06692161,0.045927767,-0.015540194,0.009824072,0.10617994,0.085162476,-0.042147163,0.0009958156,0.052195072,-0.095306985,-0.019700216,-0.025922215,0.08880447,-0.037695546,0.02213279,0.06289746,0.006718867,0.018623956,0.006330158,0.04989195,0.10461078,-0.07925012,0.040361326,-0.0010198678,0.0033013343,0.022172505,-0.08632709,0.0037323944,0.016259028,-0.08132922,0.045080293,0.060670037,-0.019455852,0.039766666,-0.069309615,-0.014948953,0.056834884,-0.08063016,0.011437038,0.028799707,-0.04883447,0.03756883,-0.0284423,0.018784607,0.045397747,0.028710263,0.03098261,-0.017697359,0.1301311,-0.023933312,0.0150139555,0.007862518,0.021843106,-0.08263287,-0.05790276,-0.071674146,0.081759974,-0.061623517,0.00028989077,-0.00429972,0.07398245,0.052711528,-0.062615246,0.044326197,-0.018966014,0.010013472,0.017929688,-0.054666623,-0.038698085,0.061628927,0.044028085,-0.1248279,0.04388351,0.00510678,-0.09559357,0.0116145555,-0.012280173,0.09239226,-0.07773372,-0.08163579,-0.0152325,0.030940445,-2.4188134e-33,-0.00713523,-0.049054045,0.0072211227,0.06977833,0.051685777,0.04660254,-0.013306877,-0.05215865,0.08441521,-0.013037303,0.09852614,0.045727916,0.044683527,-0.04402793,0.017521612,-0.004299961,0.017200653,0.09641324,0.012229938,0.021442961,0.00962903,0.0035994763,-0.055018943,0.09841105,-0.013557503,0.0574447,0.032404583,-0.1341151,0.0657858,0.040500525,-0.042524505,0.056149084,0.021599224,0.019664917,0.05440213,-0.048956085,-0.06698395,-0.048113547,-0.10003176,0.030721756,-0.048757266,-0.05883463,0.00049635046,0.040485036,0.009620498,-0.025473345,0.06278836,-0.00674737,-0.020964105,-0.039864648,0.0019569546,-0.006473223,-0.07526595,0.0401941,0.064720415,0.0067298575,0.06161766,-0.10802856,0.009209378,0.0018927148,-0.011198986,-0.030291911,0.014535976,-0.024240268,0.019526388,0.008091847,-0.04197004,0.16889769,0.014076126,-0.060128726,0.11420963,-0.038866393,0.07358026,0.01376622,0.014056959,-0.0933703,0.0066207508,-0.048877716,0.02052873,-0.014154595,-0.14048357,0.034451827,0.006740161,-0.018722668,0.0029125386,-0.12483823,0.038679767,-0.016125608,-0.09088734,0.081772245,-0.0096713845,0.054872423,-0.028009627,0.053527415,0.050523713,-2.456695e-08,0.018686337,-0.13104752,0.06313249,-0.036367677,-0.038186986,-0.007996794,0.054440692,0.054963414,-0.050359577,0.014374598,0.004373937,0.04862751,0.050978266,-0.012532271,0.016564347,0.025473785,0.0026589145,-0.057417512,-0.059735186,-0.0183622,-0.039882675,-0.002357222,-0.014776658,-0.0964039,0.015141316,-0.006830881,-0.016066335,0.038831815,0.021046907,-0.0020329652,0.045308746,-0.044189833,-0.07613705,-0.007228481,0.032301523,0.065721855,-0.0067729987,-0.08970335,-0.08217246,0.046115313,0.009273355,-0.07328054,-0.072581045,0.052059777,0.02560578,0.0030005565,-0.0034203054,-0.0349855,-0.03630466,0.00032528015,-0.00060237345,0.002999674,0.0459246,-0.0029709472,-0.0652245,0.02972571,0.0023304422,-0.027462298,-0.019837603,-0.059635945,0.015316194,0.015583357,0.12521887,0.03272991 +1.1.99.13,"The enzymes from members of the Rhizobiaceae family (such as Agrobacterium tumefaciens) act on disaccharides that contain a glucose moiety at the non-reducing end, such as sucrose, trehalose, leucrose, palatinose, trehalulose, and maltitol, forming the respective 3'-keto derivatives. cf. EC 1.1.2.11, glucoside 3-dehydrogenase (cytochrome c).",384,0.99999994,-0.04364158,-0.047927283,-0.1454244,0.0005348581,0.014313178,0.022541873,-0.057439804,0.008340875,0.053318363,0.038281526,0.039493095,-0.06031722,-0.07784496,-0.014310106,-0.034931466,-0.016288199,-0.03929052,0.044443723,-0.038161747,-0.04723875,0.10709373,0.042650245,0.008774409,0.009653747,0.101086155,0.006153502,0.0009098469,-0.010549676,-0.087150216,-0.08163318,-0.02022598,-0.049589634,0.08146956,-0.0245973,0.05940513,0.13539162,-0.06356227,-0.031733975,0.06706834,-0.032226678,0.01904324,-0.007975973,0.0088679725,0.040647868,-0.056059103,-0.05665215,-0.07559813,0.05920133,0.0398091,-0.04344479,-0.05600777,-0.049432423,-0.06356241,0.06429935,0.02512152,-0.008512765,-0.0578288,-0.038540088,-0.053391043,-0.00089839706,0.020739058,-0.03870663,-0.08280163,0.004592986,-0.09911581,-0.054913152,-0.0032755581,-0.08801721,0.03220973,0.048103582,-0.07759731,-0.06940424,0.010530773,-0.004967324,-0.03185347,0.046647165,0.0102611985,0.017458798,-0.05939774,-0.026541289,0.054034285,-0.005926449,0.07461703,0.065205246,0.013569552,-0.072972104,0.051209014,-0.010147391,0.035580643,0.00955917,0.020872027,0.0011765406,0.046114292,-0.03533356,-0.10690479,0.036790237,0.024588997,-0.0275056,0.03445141,-0.027517091,0.04188956,-0.034142166,0.05220389,-0.017626425,-0.09514623,0.06740036,-0.04455465,0.09058999,-0.007972497,-4.391681e-05,-0.048936598,0.01447872,-0.0065761018,0.024570178,-0.071132176,0.013357046,0.08091117,-0.13302304,0.008784246,0.021531997,-0.016457167,-0.020969138,0.09097959,-0.05472629,-0.0046542655,0.08482064,-0.103180155,3.6278437e-33,0.063075036,-0.004915381,-0.010875793,-0.079729855,0.070831984,0.01813917,-0.106760114,0.04111151,-0.05001539,0.027741896,-0.12819347,0.012087314,0.04646861,-0.02447263,-0.03193038,0.055685602,-0.04870865,-0.016273277,0.060375746,0.057726223,-0.007420534,0.015185041,-0.07435148,0.030924797,-0.038022842,0.03315222,-0.009448892,-0.00844923,0.0064392155,0.01184517,0.05494792,-0.032617908,-0.035356328,0.0007957568,0.06717175,0.052395847,-0.048541807,0.015451692,0.024353554,0.06725791,0.0053376625,0.010926938,0.040927198,-0.031292684,0.015941557,0.0118087195,-0.0304788,0.07107963,0.0194765,0.14002226,0.062094595,-0.064405195,0.07381998,0.056216173,-0.03604668,0.064237796,-0.04388267,0.09084424,0.041296843,-0.006414922,-0.04857719,0.034252975,-0.022481265,-0.013035145,0.0017430275,-0.01952803,-0.08036873,-0.015457055,-0.060712516,0.05598807,-0.1036039,-0.02107965,0.04884253,0.038429443,0.060506415,-0.03469571,-0.082583554,0.029053355,0.004967008,0.056778196,0.049957324,-0.012942451,0.032428376,-0.071079716,-0.061557334,-0.021555288,-0.08568042,-0.052410603,-0.014927708,-0.04005809,-0.0041869497,-0.031846076,-0.0491407,0.018251436,0.054998603,-4.8506536e-33,0.15152688,-0.06970853,0.05264807,-0.014338003,-0.010746408,0.027991215,-0.0056525767,-0.04574892,0.045554318,-0.012687853,0.11125785,0.049465764,0.02132992,-0.019892298,0.038370345,-0.039259154,-0.0050955396,0.019590886,-0.04497878,-0.0585056,-0.037110593,0.07939702,-0.042661857,-0.032776557,0.050428264,-0.002353331,-0.015433745,0.09758277,0.010208809,0.008442201,0.023751145,0.008656129,-0.0016285566,-0.041084457,-0.018345088,0.011320653,-0.10265256,-0.002270277,0.009949154,0.06574225,0.03266812,0.07046431,0.07241266,0.0648495,0.072284624,0.01397614,-0.084849246,0.030283576,-0.017158402,-0.072537094,-0.00902859,-0.032968663,-0.026024073,0.040073693,0.059539065,0.061819453,0.02495634,0.013730185,-0.009343456,0.030808127,-0.00052414025,-0.044087965,0.079375386,-0.0027776328,0.041394945,0.048237547,-0.03202384,0.060657028,0.05984705,0.09628982,-0.022018006,-0.028501702,-0.025187751,0.028378623,-0.038868096,-0.03704877,-0.10484749,-0.017691959,-0.05833741,-0.03622622,0.053630665,-0.006594975,0.0061861323,-0.04142383,-0.021429868,-0.08398008,-0.028914616,0.08703967,-0.008997364,0.042997405,-0.014276343,0.0056529567,0.042026967,0.10525435,0.1056596,-4.5108457e-08,0.051524904,-0.03386806,-0.015454124,-0.009754342,0.03109782,0.05389579,-0.012620608,-0.0038852612,0.061478842,-0.0072047887,-0.025572782,0.09698585,-0.034403272,0.048987586,0.015740547,0.049991142,0.021665208,-0.0015290104,-0.0056732926,0.028686306,-0.080128685,-0.011678427,-0.11839154,0.049001645,0.047481768,-0.046546526,0.032209285,-0.029495312,-0.013694369,0.013370728,0.033678673,0.08415298,0.070237,0.007635742,-0.08617647,-0.010713342,-0.073555104,-0.052300252,-0.02496199,-0.0026684448,0.07158534,-0.012168341,-0.076017104,0.013225778,-0.08378565,-0.005702507,0.009040807,0.018509109,-0.023662932,0.010117963,-0.0333185,0.028361514,-0.08540792,-0.020172678,-0.028801091,-0.007441071,-0.0035023093,-0.04456582,-0.03609193,-0.05391751,0.0035322295,-0.035273276,0.15218219,0.0042647445 +1.1.99.14,"Also acts on (R)-lactate. 2,6-Dichloroindophenol and phenazine methosulfate can act as acceptors.",384,1.0,-0.062554024,-0.11957018,-0.032714475,-0.009092484,0.08026917,0.044733044,0.0058590486,0.074727,0.016246218,0.00027859787,0.0049402663,-0.017045379,-0.07966997,0.08377176,-0.031318426,0.04127659,-0.066821285,0.04365376,-0.014372455,0.077242866,0.048562177,0.04827891,-0.0037146744,0.0017309921,-0.011006169,0.07094481,0.05662881,0.024016172,0.025541613,-0.06485426,0.0024938616,0.0139981415,0.019280076,0.0340904,-0.07066106,0.05642349,-0.015880438,-0.040786106,0.009181104,-0.008142197,0.04033886,-0.02813415,0.03992053,-0.014850703,0.0015703287,-0.05370892,-0.023134155,0.054407854,0.00030672262,-0.033189755,-0.059939835,0.030063067,-0.015659027,0.10271755,-0.038941298,0.05688267,-0.113866664,-0.0134006785,-0.005143065,-0.040215816,-0.029903637,-0.02109545,-0.020534964,-0.0011016617,-0.027992124,-0.005919856,0.021850325,-0.0016029829,0.06683694,-0.04059137,-0.06827612,-0.024519982,0.03827264,-0.080095045,0.06269827,0.06670806,0.010063948,-0.035079382,0.05611016,-0.06692566,-0.05646594,-0.07559318,-0.017093787,0.029194955,0.05113461,-0.033411935,-0.021818101,-0.0039894194,0.077348255,0.035532843,-0.009280703,0.037623845,-0.007571327,-0.04213328,-0.14307876,-0.008279009,0.017458359,0.031816714,-0.004749351,0.03427195,-0.021702081,0.022918906,-0.10535267,-0.042547975,-0.08556915,-0.031295247,0.02756062,-0.015338353,-0.032022435,-0.017528754,-0.05699027,-0.045968905,0.06846533,0.065451354,-0.035036106,0.07696983,0.063348,-0.1310513,-0.026209142,-0.096132606,-0.04272149,-0.055750377,0.0353279,-0.064217456,-0.051932372,0.029096251,-0.011231693,2.452469e-33,0.038568247,0.01731947,0.029628303,0.00011498781,0.0068713776,0.041490458,-0.10931431,0.03243016,-0.0015198125,-0.13569243,-0.007090434,-0.014806481,0.02156361,0.066367745,-0.024797248,-0.005350178,0.05373724,0.020884145,0.075765796,-0.040718436,0.007965022,0.12401051,-0.058331124,0.025109313,-0.017456518,0.022365168,-0.0060100346,0.049738407,0.011466117,-0.000257584,0.07464492,-0.06410094,-0.011406778,0.095431335,-0.028608445,0.11090782,-0.07347469,0.0051818783,-0.01007506,-0.061431494,-0.0029953246,0.0003012723,-0.07260016,0.073114425,0.02144225,-0.02688207,-0.046780244,0.0015537201,0.005800528,0.085312486,-0.0052940655,-0.04051318,0.031518463,-0.05377817,-0.021003125,0.0044513675,-0.03850763,0.037973374,0.055377077,-0.00075573777,0.014701163,0.090665966,-0.02924091,0.0063683256,-0.013539025,0.005479991,-0.07205742,-0.08061373,-0.0074793547,0.04839307,-0.045773543,-0.033111915,-0.0021468704,0.12239818,0.039048992,-0.01434798,0.010251756,-0.048978824,-0.009527465,0.031128334,-0.036389578,-0.06275426,0.0057492396,0.104853675,-0.13414916,-0.012988229,-0.013095824,-0.07889968,0.03292095,-0.004244582,0.09709192,-0.07474291,-0.03305888,-0.006145163,0.05007665,-3.533571e-33,0.06503281,-0.05875504,0.039344184,0.05501492,0.0069285366,0.02840322,-0.0077372394,-0.08770306,0.11811069,-0.10044807,0.080639824,-0.021738203,0.0065476955,-0.003137023,0.004895528,-0.0009673059,0.09459251,0.050161034,-0.016724788,0.037065927,0.009595097,0.11775509,-0.015414974,0.08092147,0.016021682,0.04789848,0.024214242,-0.040392537,0.011778861,0.023094848,0.0055173393,0.059846688,-0.0131811295,-0.06415975,-0.012424708,0.0044540092,-0.043738645,-0.027552921,-0.10817563,-0.007825108,0.020936789,-0.010014309,-0.004578677,0.085385345,0.033314772,-0.0013480688,0.046061654,-0.045538064,-0.0702461,-0.0043960027,0.009927625,0.025122294,-0.021623446,-0.003984716,0.123445995,0.07909695,0.034977984,-0.12625904,0.028941313,-0.035586935,-0.0054184766,-0.035877924,-0.03189299,-0.1028242,0.018047865,-0.039155204,-0.008767147,0.047887668,0.11324062,-0.0641364,0.09977987,0.008090864,0.059692267,0.048728198,-0.033103656,-0.068128325,-0.050142616,-0.038723506,-0.012066694,-0.032654453,-0.08040945,0.020068936,0.053375352,-0.024197532,-0.026347337,-0.050518222,-0.039658222,0.011414152,-0.022950001,0.065861866,-0.016958242,0.0072086304,-0.033615917,0.09375482,0.044101615,-3.1552744e-08,0.041498262,-0.095537625,0.05416806,-0.027161086,-0.067118116,0.002802995,0.038427126,-0.010459183,-0.0151515,0.01367833,0.010507555,0.10959885,0.084967956,-0.047832172,0.019052127,0.028040487,-0.0329992,0.0045287507,-0.112690106,0.01004712,-0.08313288,-0.05230915,-0.059665866,-0.0015248064,0.048566367,-0.051688973,-0.011131939,0.01905625,-0.0051162685,-0.057431288,0.073871166,0.026689878,0.06640684,-0.035826635,0.033258528,0.040154904,0.042313393,-0.03834325,-0.05845972,0.055616427,0.056479383,-0.0010604368,-0.07055067,0.06596448,-0.00012997414,0.043927737,-0.037975535,-0.0074617225,-0.013517197,-0.038670685,0.028221607,0.025920052,0.020422356,0.018530319,-0.08849899,0.018104624,0.007057335,-0.0111936685,0.0022089113,-0.10020893,0.0633272,-0.0050401725,0.101611495,0.012405234 +1.1.99.16,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.1.99.18,"Also acts, more slowly, on cello-oligosaccharides, lactose and D-glucosyl-1,4-beta-D-mannose. The enzyme from the white rot fungus Phanerochaete chrysosporium is unusual in having two redoxin domains, one containing a flavin and the other a protoheme group. It transfers reducing equivalents from cellobiose to two types of redox acceptor: two-electron oxidants, including redox dyes, benzoquinones, and molecular oxygen, and one-electron oxidants, including semiquinone species, iron(II) complexes, and the model acceptor cytochrome c [9]. 2,6-Dichloroindophenol can act as acceptor in vitro.",384,1.0,-0.030380126,-0.037096683,-0.0747661,0.022594254,0.07272577,0.0014305953,-0.007880947,0.038243104,0.07523087,-0.033255573,0.040420786,-0.015632465,-0.042505566,0.027786946,-0.06660853,0.01848701,-0.07358755,0.029760472,-0.0628259,0.059755784,0.008608669,-0.035231154,-0.024807375,0.02683506,0.009164212,-0.027667096,0.044085715,-0.019642724,-0.12268299,-0.065157056,-0.017245494,-0.0074655754,0.030234424,0.029601656,-0.0471274,0.07960692,0.030418927,-0.06448717,-0.0030884782,-0.01886656,-0.013587966,-0.012861191,0.07038849,0.056308415,-0.054575503,-0.03794722,-0.028242256,0.046292625,0.07109189,-0.04400808,-0.034305036,0.0037002023,-0.022860857,0.1268977,-0.02863174,0.09713387,-0.017845573,-0.0058033643,0.02921748,-0.0195503,-0.017143099,-0.021743264,0.023182195,0.033756793,-0.06857107,-0.033259153,-0.024868805,-0.08578243,-0.04820094,-0.07811899,-0.050203726,-0.0034559444,0.004524152,-0.04676375,0.061409716,0.12799285,0.021931086,-0.0077477153,-0.006217516,-0.023785906,0.03882883,0.010018848,0.078291416,0.060759474,0.020889688,-0.017938308,-0.0035414281,-0.0040349774,0.0072910753,0.057137016,0.060144685,0.06797222,0.040386666,-0.008598656,-0.09084362,0.058970254,0.107974164,0.08802722,0.040647496,-0.024010718,0.008787308,0.0040442836,0.0233867,-0.11327983,-0.038525518,-0.024596725,0.0016149011,0.025623275,0.07576628,-0.084229514,0.012115406,0.007956717,0.05813296,-0.042308416,-0.023761995,0.07317902,0.04663232,-0.10268724,-0.080209516,-0.006186045,-0.0046958835,0.0035804922,0.031961367,-0.08404066,-0.015323392,0.017079528,-0.037119865,2.8951739e-33,0.020399598,0.042086866,-0.022180645,0.0025424203,0.03711111,-0.035042655,-0.1013322,0.037326418,-0.03879662,-0.08486296,-0.07039941,0.009767861,-0.052751713,0.022188425,-0.016353872,0.08601689,0.0041844435,-0.051768765,0.0766712,0.034980923,0.035794936,0.0031303617,-0.03557171,-0.008561904,0.07420113,0.0801596,-0.07107476,0.026371537,-0.01950844,0.0025916996,0.10055742,-0.06976356,-0.07921237,0.040406562,-0.015497511,0.050362658,-0.046484485,-0.024621472,-0.041219,-0.056625657,-0.065140694,0.00070494646,-0.07730568,0.034521695,0.10578098,-0.07419874,-0.043527957,0.04606021,0.03726893,0.10745498,0.020470344,0.02829681,0.061487388,-0.006119782,-0.023474256,0.010323276,0.01372367,-0.017699724,0.013106756,0.02645734,0.013428696,0.13858037,-0.05016467,0.050474167,0.038965672,0.004390811,0.017407652,-0.0005910879,-0.052204773,0.014103619,-0.032548144,-0.030402249,-0.042100657,0.0041643665,0.012571885,-0.057104692,0.012919921,-0.10676804,0.04650804,-0.024957482,0.03341269,-0.068986155,-0.021941043,-0.018399475,-0.09848717,0.030692145,-0.03239233,0.015572394,-0.042869054,0.012834458,0.024608463,-0.044207685,-0.059639707,-0.03539232,0.040914677,-3.3518894e-33,0.08809753,-0.109406665,-0.013720669,-0.02492849,0.010428534,0.06757517,0.007780503,-0.008307187,0.044629186,-0.0639939,0.094458945,0.013081352,-0.02930182,0.019687783,0.014262622,0.031819075,-0.033201516,0.11632633,-0.003966657,-0.0020847002,-0.024761753,0.10957351,-0.011622423,0.081213646,0.051226366,0.008087789,0.017664712,0.03371725,0.0146204,0.03426413,-0.024044061,0.0280312,0.019509016,-0.026537446,0.011060511,-0.006256933,-0.10708554,-0.028912196,0.072737984,0.049615946,-0.002808888,-0.033577733,-0.06974935,-0.03538068,0.0140161775,0.112082735,-0.13526198,0.03601118,0.07151688,-0.01251398,0.029609932,0.052716542,-0.030367708,-0.010400276,0.116332844,0.036256786,0.017549211,-0.03593636,0.024414236,-0.015416978,-0.0684311,-0.012071993,0.041824862,0.017243383,0.02453327,0.054352712,-0.050548654,0.036644034,-0.014583595,-0.046701036,0.073676,0.029617632,0.023612518,0.048784204,-0.049722575,-0.02234065,0.0045622727,0.027859537,-0.020309161,0.056355566,0.03168755,0.015982753,0.13185021,-0.04669383,0.02584421,-0.08492417,-0.042818196,0.022870863,-0.050228957,0.014041402,0.020665737,0.039459977,0.024918484,-0.002075995,0.097726814,-4.6094048e-08,0.03315135,-0.008620844,0.06865095,-0.14235479,-0.0048103714,-0.016615752,0.047593683,-0.04833582,-0.028218374,-0.0048036617,-0.015318432,0.13557819,0.036291447,0.031176437,0.03339012,-0.01453469,-0.01534035,-0.055570304,-0.032276947,0.07718973,-0.051111966,0.00014301088,-0.110023096,0.002303479,0.04539677,-0.055639848,0.0569261,-0.007934328,0.019770667,0.032720935,0.009394154,0.0073382067,-0.0039291936,-0.017635074,-0.093097754,-0.009390822,-0.033972234,-0.074492864,-0.06825886,0.0042617023,-0.0268373,-0.06521491,-0.047799658,-0.039347008,-0.047452416,-0.041681357,0.022896439,0.009057684,0.009081787,0.04078624,0.025833296,-0.042909928,-0.028190076,-0.03807157,-0.107905,0.01706596,0.08028595,0.030423312,-0.037592698,-0.11960296,0.0018310014,-0.032731984,0.16413791,-0.012131159 +1.1.99.19,Also oxidizes thymine. The enzyme acts on the hydrated derivative of the substrate. Formerly EC 1.2.99.1.,384,1.0,-0.05393959,-0.0056364946,0.03951782,0.013781062,0.13494687,0.03654184,-0.028404513,0.06211503,0.026317516,0.014504522,0.024906205,0.012573191,-0.036607094,0.06313371,-0.040189788,0.004014884,-0.053091478,0.019702766,-0.014440743,-0.09346994,0.017336208,0.0113426065,0.0352671,-0.0049600583,0.020636562,0.024004294,0.059446685,-0.044805977,-0.0044043814,-0.09740938,-0.04453086,-0.014336568,-0.009695181,-0.06326292,-0.0661134,0.09793402,-0.047254812,-0.040101185,-0.021267794,-0.010650436,0.052619424,-0.04773291,-0.06265698,-0.05699596,-0.030517902,-0.012726489,0.015741466,-0.0018563137,-0.008608042,0.09118929,0.005474145,0.0026450793,-0.02292911,0.015139633,-0.06861012,0.05769946,-0.07167234,0.043452937,-0.095749356,0.017243419,0.0055827093,0.019123998,-0.025554514,0.045210566,0.07608185,-0.05919405,0.051581413,-0.037215665,-0.019218199,-0.08932779,-0.0011723388,-0.08337103,0.017401563,-0.0071676406,0.010888216,-0.040774077,-0.01597848,-0.08254296,0.08784099,0.04048253,-0.03785002,-0.020934053,0.024057394,0.060436506,0.053765412,0.029604811,0.019924691,-0.079509184,0.04704568,0.008491543,0.030193644,-0.0032740775,-0.059290927,0.016961563,-0.04171423,0.048680235,0.02794744,0.10944055,-0.0078006987,-0.009689694,-0.01407612,0.08589625,-0.107693076,-0.01841399,0.024146153,-0.0024003885,0.026052808,0.06510038,0.02637742,0.008601075,-0.0013366559,-0.01673835,0.059370287,0.053177156,-0.041541275,0.06495623,0.010670798,-0.020399336,-0.04825571,0.01137867,0.060456518,-0.039517343,0.007453425,0.09469062,-0.03276973,0.041032918,-0.051949035,-2.5896668e-33,0.05523472,-0.035785746,-0.0017208605,-0.04464262,0.008971073,0.019845214,-0.075584136,0.0336557,-0.040904265,-0.027780924,-0.05622772,-0.0094257435,0.04024501,0.019223806,-0.011947864,-0.06930838,-0.051381372,0.07057282,0.08062728,-0.008477209,0.052945983,0.03683885,-0.0196631,0.08411172,-0.01765003,0.0072704447,-0.007255143,0.07478837,0.014786033,0.0049823374,-0.0013364594,-0.057577588,-0.054228373,0.033874318,0.037964303,0.06529964,-0.082063645,-0.00052169233,0.013538615,0.113510035,0.008799266,0.021027027,0.0032831337,-0.048417177,0.008075271,-0.09427942,-0.031895,0.061647274,0.053092867,-0.012521097,-0.011575754,-0.043970928,0.0890443,-0.01999802,-0.004525755,-0.021520536,-0.008403638,-0.064863585,-0.01487655,0.037599355,-0.033054337,0.040984973,-0.031014862,0.054730922,-0.018850226,-0.018192902,-0.070470974,-0.033929326,-0.003938032,0.0467946,-0.089687616,0.042113565,0.08558115,0.004818036,0.02843245,-0.03861616,-0.06975546,0.04680358,0.03298464,0.0023874976,0.027098766,-0.063501224,0.004346034,0.078853875,-0.019000087,-0.040685963,-0.024341216,-0.053555414,0.03558815,-0.00955717,0.114855364,-0.061743934,-0.08453473,-0.07245857,0.0013808528,1.00009875e-33,0.10043575,-0.056394827,-0.028282335,-0.010650059,-0.020543521,0.043852497,0.032496296,0.04700747,0.03224105,-0.05135363,0.040478796,0.015155835,-0.058763474,-0.06883989,0.030397937,0.016433552,0.012405987,0.05142825,-0.03672646,-0.019086773,-0.032651145,0.069351345,0.010262501,0.03004888,0.103179775,-0.030198112,-0.042730235,0.0043868474,0.071782395,0.03789905,-0.07379485,-0.024940217,-0.04791916,0.02229757,0.028185973,0.041203305,-0.016249843,-0.016656175,0.002097288,-0.0029093414,0.06472488,-0.039538685,0.05281894,0.030753223,0.08049218,0.056783788,-0.07561653,-0.031604428,-0.08677615,-0.03819441,0.05643615,-0.0150547,-0.018157884,0.0054951757,0.04041784,0.020924343,-0.041144963,-0.015520964,-0.007930402,0.008263903,0.029290633,0.017982977,-0.008671953,0.00042563613,-0.05704318,-0.003191486,-0.09662145,0.09076083,0.059694853,0.044660162,0.105240986,-0.031168103,0.07611069,-0.031347476,-0.038376275,-0.04524562,-0.038456276,0.009211644,0.020128809,-0.066456564,0.034376744,0.037857607,0.012199596,-0.13107142,-0.0037713721,-0.031942826,0.01126611,0.13109384,-0.008927983,0.063299105,-0.04763288,-0.09047713,-0.09793152,0.077411756,0.061938077,-2.9283683e-08,0.0027786186,-0.05230451,0.0711899,-0.013389005,-0.0012777592,0.07805954,0.12965931,0.04584342,0.04646223,-0.033241622,-0.028865293,0.13735072,0.079891115,-0.026700577,0.06959592,-0.0012285276,-0.017602503,0.03139672,-0.061718732,-0.030970797,-0.12218361,0.008378232,-0.07786872,0.023954473,0.02109406,-0.022516552,0.0067817857,0.03963676,0.016084077,-0.07728258,-0.006301719,0.017726807,0.041525017,-0.03938117,-0.008266241,0.033650972,-0.0033058843,-0.036332697,-0.052432023,0.026113393,-0.050400425,-0.018875439,-0.05714956,0.019031895,0.088377215,0.007408072,0.008558037,0.015141189,-0.02380131,-0.037668902,0.02267754,0.01332716,-0.07889012,-0.08495415,-0.0916764,0.0150035815,-0.01193907,-0.1239016,-0.02375067,-0.09442412,0.029737229,0.06814716,0.22571121,-0.0778257 +1.1.99.20,"A quinoprotein. Acts on C3-C16 linear-chain saturated primary alcohols, C4-C7 aldehydes and on non-ionic surfactants containing polyethylene glycol residues, such as Tween 40 and 60, but not on methanol and only very slowly on ethanol. 2,6-Dichloroindophenol can act as acceptor. cf. EC 1.1.2.7, methanol dehydrogenase (cytochrome c) and EC 1.1.2.8, alcohol dehydrogenase (cytochrome c).",384,0.9999999,-0.07449,-0.06862742,-0.0299127,-0.0862863,0.09046396,0.028613925,0.0081561,0.05818399,0.031002747,0.015223377,0.052596334,-0.03256195,-0.11588379,0.076377906,-0.008637995,0.12517498,-0.041302986,0.007061218,0.009594668,-0.0094760405,-0.041256182,-0.028481467,-0.058164224,-0.034471776,0.0018129859,0.013762885,0.017531345,0.07082678,-0.03217415,-0.013704307,-0.0285463,0.050373197,0.026754407,0.007940232,-0.00818279,0.065920375,-0.06011447,-0.040382944,0.06494096,0.008954252,0.047175262,0.013840059,-0.0043525877,0.02796325,0.029246472,-0.024577074,-0.017539281,0.12416935,-0.018394396,0.014583905,-0.04892753,-0.035667855,0.031910386,0.079651244,0.029582014,0.05120281,-0.082264856,0.0114669,0.009301321,0.07636256,-0.02545118,0.028293611,0.0080955,0.037029058,0.0062392796,-0.046851218,0.004250759,0.013137643,0.058432344,0.0020989955,-0.06255739,-0.03871552,0.05758303,-0.04160084,-0.02174255,-0.024028156,-0.02850978,0.003766284,-0.002247645,-0.06951174,-0.039155256,-0.0077777533,0.03646758,0.09206471,0.059167746,-0.055927195,0.009374658,-0.004749129,-0.029777542,0.06368561,-0.0032345434,-0.02188256,-0.0018437142,-0.12760143,-0.05137314,0.066995434,0.06158011,-0.03397696,0.013403024,0.012626571,-0.0008643367,0.020601796,-0.020853013,-0.123701654,-0.06923121,0.041374277,0.007357001,0.02270725,0.000349327,0.04449682,-0.06637019,-0.052709907,0.072560914,-0.023586994,-0.021709839,0.013088828,0.053836703,-0.09175769,0.017061112,-0.085596584,-0.037943713,0.0090385,0.082372986,0.01654129,-0.018012686,0.059017714,-0.00993905,5.005381e-33,0.03290461,-0.038977597,-0.043743268,0.046095066,-0.002607246,-0.021105124,-0.02196712,0.059982534,-0.067681246,-0.049718365,-0.05758287,-0.019269077,0.04864903,0.03526901,0.02433756,0.06008382,0.03013818,-0.046291262,0.047978364,-0.04863234,-0.010246134,0.014462411,-0.12987433,-0.049460977,0.005005341,0.0629749,-0.044417497,0.035733495,0.058545034,-0.008997632,-0.020940512,0.0064841467,0.02221862,0.076822676,-0.011409145,0.072482385,-0.07794991,-0.019055165,-0.07193926,0.0148755,0.009468684,0.035696704,-0.0034231446,-0.057261884,0.015425467,-0.0063162902,-0.027447734,0.055896997,0.02356707,0.02549195,0.052553408,-0.026679516,0.028254285,-0.10207201,-0.10174692,0.049922753,-0.022992989,0.011751956,0.024422934,0.01643122,-0.07263152,0.052321427,-0.088294394,-0.024148347,0.02034204,0.06890459,-0.069779195,-0.09019434,0.00930042,0.04369695,-0.06407178,0.0018307172,0.06476061,0.008523552,0.0039699986,-0.0041415533,-0.023892907,-0.045566756,0.02465656,0.061291255,0.014817204,-0.03008405,0.05567078,-0.04391962,-0.030657336,-0.057561368,-0.022857038,-0.08899762,0.027949708,-0.008944071,-0.0035509646,-0.060461037,-0.040570553,0.061372854,0.051944923,-6.1366264e-33,0.070449345,-0.10549515,0.031797327,0.04471625,0.008705438,0.11861043,-0.016396955,-0.0831863,0.031377427,-0.028070372,0.09829296,-0.07526094,0.0017257852,-0.022389796,0.014783944,-0.0015938114,-0.04796218,0.0961076,-0.018208941,0.0012518611,0.0175438,0.05222678,0.023089088,0.04700346,0.025470145,0.050399967,-0.019615432,-0.01612851,0.064667605,0.073971964,-0.050097696,-0.009836596,-0.007290875,-0.018375557,0.048986454,0.06464351,-0.09739034,-0.0014442386,-0.046958838,0.035451874,0.01813723,-0.014002504,0.023164114,0.054806728,-0.01558497,0.05833381,-0.040421806,0.0014660686,-0.04118812,-0.032914743,0.040107306,-0.0027390376,-0.051807903,0.06103294,0.09017464,0.1373599,0.04147932,-0.0902164,0.013940698,-0.04404478,-0.07244941,-0.055561215,-0.009796576,-0.03323781,0.01276752,0.034805827,-0.10028941,0.15286352,0.02016533,-0.078487165,0.07239575,0.007121345,0.03673552,0.019427095,-0.034786843,-0.09515258,-0.023822268,-0.037809573,-0.02867209,0.021486348,0.04116407,0.057402924,-0.049403746,0.0040198048,-0.023139996,-0.0676305,-0.0011371635,0.022199348,-0.015397752,0.043331936,0.061651144,0.08947908,-0.083544426,0.08440199,0.04326284,-4.788131e-08,-0.013999521,-0.0018989309,0.08311936,0.018505383,-0.01149112,0.003775136,0.0754622,0.035546124,-0.011258874,0.016560888,-0.006510851,0.06543132,-0.022806823,-0.041798253,0.03816966,-0.013364896,-0.072779715,-0.05119069,-0.050614234,0.040213324,-0.050185557,-0.022255203,-0.07267751,-0.00785592,-0.053825904,-0.08898327,0.022837585,0.040537573,-0.06178069,0.013970646,-0.07345746,0.05864482,-0.07674499,0.0045391056,-0.013752571,0.014419156,-0.0007142002,-0.07282501,-0.1321445,0.029130172,0.041942228,-0.06333472,-0.114661425,0.016854567,0.03568676,-0.053368345,-0.008252488,0.011990524,-0.027259499,0.044310465,0.047891993,0.039924905,0.08387977,0.0055060186,-0.032514703,-0.001580088,-0.00056492176,-0.07833846,-0.03874968,-0.045211855,0.05955681,-0.03662029,0.20067097,0.07679238 +1.1.99.21,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.1.99.22,"A quinoprotein. Also acts, more slowly, on a number of other polyols including D-sorbitol, D-arabinitol, meso-erythritol, ribitol and propane-1,2-diol.",384,0.99999994,0.02884083,-0.13244665,-0.021040076,-0.027431434,0.05171696,0.008786951,0.06447541,0.04417669,0.12305283,0.059285272,0.012193433,0.046025686,-0.056093838,0.053973936,0.022680204,0.056339715,0.032596167,0.035009492,-0.044039145,-0.047226522,0.0071486603,-0.038873207,-0.051939573,0.014168737,0.011243661,0.020665336,0.02460626,0.009632131,0.01325068,-0.09192646,-0.010648478,0.039675355,0.019138549,-0.028076649,-0.0012999795,0.113248706,-0.03268221,0.02622961,0.010645439,0.023412334,0.03406775,-0.018856056,0.04855177,0.011280664,0.018533021,-0.0082552,-0.06403692,0.1371499,0.046100244,0.038282115,-0.12564087,-0.07975975,-0.060240213,0.032564837,0.031900845,0.05977664,-0.086541474,0.013542719,0.032261085,0.024760958,-0.0040395614,0.031592682,-0.011956653,0.029838447,-0.006324066,0.031487487,0.06530869,-0.02104629,0.0066338973,0.07856801,-0.02373589,0.016948944,-0.008592717,0.02512829,0.04459124,-0.12538205,-0.035662923,-0.04702303,0.06942365,-0.03994976,-0.01651732,0.08405063,0.0063430727,0.031944342,-0.018010674,0.069867946,0.03727403,0.016316202,-0.0072164107,-0.016211348,0.039362323,-0.058674827,0.027662655,-0.098300695,0.0055848234,0.016885754,-0.00030245655,-0.05075004,0.024997713,0.000987528,-0.011234532,-0.0059147133,-0.006456021,-0.12030974,-0.092703044,0.015681177,-0.042276315,0.026537227,0.014804843,0.06581265,-0.06019315,-0.059821416,0.034357764,-0.020673031,-0.0773732,0.016509496,0.05962644,-0.047871713,0.035010986,-0.0490551,0.024628114,-0.008362865,0.033791065,0.044300586,-0.029295422,0.031870432,-0.04568952,1.6383803e-33,0.043468025,-0.075106986,0.0059313593,0.07543159,-0.061148684,0.013364637,-0.01604636,0.0051506674,-0.0611538,-0.033150606,-0.08761359,-0.052128293,0.032877553,0.071399026,0.022209914,0.011514706,0.0024298376,0.0044078506,0.044737875,-0.05863102,-0.032615844,0.11588026,-0.061224137,0.036495537,0.012664866,0.015569304,0.023133166,0.0010764118,0.0148041,-0.0058555305,0.009933182,-0.036275037,-0.03374537,0.11832919,0.00571211,0.009841267,-0.08665807,-0.020381693,-0.011762502,0.03128836,-0.052300293,0.011558251,-0.043995064,-0.026120821,0.056752406,-0.04860698,0.011926312,0.06693137,-0.080445446,0.025372531,0.09683667,0.027376585,0.008506325,-0.046109132,-0.15780339,0.024170978,-0.034055803,0.05840634,0.015229832,0.069027476,-0.06901064,0.038579762,-0.04657347,0.00744427,-0.008860384,0.01478757,-0.08370291,-0.07260427,0.10030439,0.030328544,-0.014419597,-0.010740931,0.04482442,-0.0047318735,0.036131136,-0.025229027,-0.026318112,-0.06542809,0.010854082,0.045920465,-0.034115598,-0.039967384,-0.013839632,0.031421497,-0.043615554,-0.024463808,0.046455823,-0.118347876,-0.0018507736,0.0043208245,-0.04730245,-0.07457147,-0.052755404,0.056889437,0.07043463,-3.0626956e-33,0.02327375,-0.1472667,0.03007986,0.10167463,-0.010850512,0.028836127,0.020553693,-0.08155428,0.021922072,-0.048642848,0.091918714,-0.052058134,-0.0036211484,-0.027418436,-0.008144943,0.051764198,-0.016298339,0.0073336326,0.013688885,0.0500586,-0.04705934,0.04406377,0.042730395,0.051633157,0.029096382,0.036089014,0.009193383,-0.012213366,0.021292204,0.11697688,-0.029211793,0.0007869912,-0.059312996,-0.05431725,-0.03790549,0.048982,-0.055062447,-0.015550681,-0.038489383,-0.029791692,-0.07771232,0.016582252,0.1493926,0.02895557,-0.002790098,0.04944829,-0.045711376,-0.0064998292,-0.06875219,-0.0006843709,-0.0027862755,0.025667636,-0.02951216,0.06661165,0.06110175,0.070669875,-0.009221982,-0.025193056,-0.00022949502,-0.023855379,-0.0767052,-0.05439899,0.053808466,-0.0023493706,0.109330714,0.0054328004,-0.06608427,0.015543826,0.04881001,-0.050185323,0.12091292,0.00015392447,0.0015755609,0.053659547,-0.023286516,-0.11901992,-0.013860767,-0.05046045,-0.04579609,0.050931074,-0.00025185564,-0.010656797,-0.06583128,-0.042712424,-0.07833135,-0.06989539,0.037028197,0.06399905,0.018763017,0.09850065,0.0055066105,0.052158475,-0.05432437,0.07233222,0.06833042,-4.0207784e-08,0.0013436393,-0.052699097,-0.0075091943,-0.042397704,-0.0054435236,0.00081239373,0.042478897,0.104941435,-0.040527552,-0.0057845796,0.04082071,0.086844295,-0.020995878,0.010584518,0.08797837,0.012568922,-0.031181062,-0.04985477,-0.04816829,-0.056941442,-0.029194942,-0.01431482,-0.070010565,-0.059166778,-0.06855612,-0.10361811,0.027349187,-0.029816922,-0.014375894,0.0099400515,-0.054449353,0.053742588,-0.05392489,-0.08837885,-0.008322609,0.07836335,0.0031015894,0.027590906,-0.025141524,0.05809181,0.016736232,-0.01851672,-0.08401116,0.016729953,0.017372308,-0.12003528,-0.015999304,-0.011430159,0.006917768,-0.0036881706,0.07168571,0.0044153277,-0.0033961863,-0.02160857,-0.05466809,0.03714366,-0.023836562,-0.07702722,0.022846574,0.003016729,0.015954692,0.00342071,0.14917798,0.01659957 +1.1.99.23,"A quinoprotein. Phenazine methosulfate and 2,6-dichloroindophenol can act as acceptors. Also acts, more slowly, on 2-hexanol and some other secondary alcohols. cf. EC 1.1.99.8 alcohol dehydrogenase (acceptor) and EC 1.1.99.20 alkan-1-ol dehydrogenase (acceptor).",384,1.0,-0.049363684,-0.040988196,-0.06715445,-0.06475052,0.09845524,0.0016757584,0.01137954,0.05073752,0.023067245,0.03421713,0.022959279,-0.03532307,-0.119674996,0.07449211,-0.004071134,0.095503345,-0.04626187,0.006589966,0.010020409,0.00875332,-0.02052639,0.013948532,0.015776105,-0.058148604,-0.021818189,0.062500075,0.019466892,0.070811994,0.016575728,-0.083648026,0.028303847,0.03450049,0.034963235,0.019475726,-0.07252238,0.0411685,-0.028949581,-0.013473953,0.028594635,0.025867894,0.03750342,0.0076712496,-0.052422285,-0.0025918053,-0.048690345,-0.0569956,-0.06948133,0.11842891,0.017011449,-0.0289608,-0.04195105,0.006452575,0.012249777,0.083017185,9.104593e-05,0.012219924,-0.07338395,0.017560778,-0.023024492,0.024140297,-0.04169516,-0.023385974,-0.041851122,-0.021591239,0.003564327,-0.018656986,0.0061560594,-0.009229124,0.05281026,-0.0034373784,-0.010562754,-0.041665502,0.07478567,-0.03322018,-0.011149658,0.010630126,-0.0129921315,0.018116632,0.03352896,-0.06706522,-0.067112125,-0.034082163,0.0008839287,0.027623316,0.086276524,-0.027240323,-0.064665616,0.022043735,0.046452034,0.075312465,-0.021259231,-0.027335318,0.0088984035,-0.10809107,-0.032557998,0.048801072,0.05573247,-0.00054292066,-0.013426764,0.012475062,-0.0042856624,0.041661423,-0.08113159,-0.0891123,-0.079949364,0.0052003437,0.044769723,0.010864401,-0.02602235,-0.006048268,-0.048833776,-0.08291944,0.099709876,-0.0047184285,-0.022045558,0.057110976,0.056266945,-0.12679572,0.0019200945,-0.112935826,-0.061300457,0.010803529,0.07162262,-0.029173838,0.014259701,0.04842798,-0.020743063,2.2651418e-33,0.0034440982,0.04207217,-0.042246804,0.036689136,-0.04234175,0.03531545,-0.077399336,0.09716147,-0.034607723,-0.15215425,-0.07252403,-0.0004678255,0.026807116,0.0290296,0.0070510306,-0.03155619,0.06670038,0.037007783,0.09080898,-0.06687244,0.00072929164,0.024654081,-0.09504433,0.015728226,0.0025407977,0.042860623,-0.0010412611,0.036646523,0.04119902,-0.010125574,0.046954013,-0.00879504,0.02638743,0.07846361,-0.052740566,0.0761587,-0.06590391,0.017055973,-0.048881423,-0.045269363,-0.03296103,0.03345966,-0.03558059,0.031661805,0.017882215,-0.026338443,-0.020339873,-0.02722539,0.003011488,0.045203935,-0.0142498035,0.0030730392,0.029957779,-0.08653252,-0.10045443,0.043736644,0.00959976,-0.009158277,0.048846956,-0.010038802,-0.03222801,0.10545222,-0.07949166,0.018849222,0.0041936594,-0.0054167253,-0.05018946,-0.10935296,0.009371123,0.06493834,-0.046917144,0.0029996461,0.05631342,0.05263161,0.0076629287,-0.0037326743,0.034021888,-0.057452835,0.008902834,0.026834087,0.0031998637,-0.06443085,0.00883789,0.06694255,-0.06430999,-0.026327757,0.009356142,-0.11293246,0.018986639,-0.015252139,0.04035815,-0.098609336,-0.054449424,-0.0012502267,0.07965351,-2.6905905e-33,0.09163319,-0.08309632,0.047525678,0.04261124,0.039659347,0.15050647,0.0018175471,-0.08899398,0.0629755,-0.059198495,0.10328024,-0.028151982,0.05019137,-0.0540477,0.038203273,-0.012617143,0.027299628,0.06025639,0.01704008,0.021426339,0.017933065,0.10798512,0.031202497,0.05529131,0.022189338,0.0378887,0.004612086,-0.0076450934,0.013377336,0.05271254,-0.009972288,0.021935362,0.0008182018,-0.05060467,0.053576782,0.038110968,-0.105760135,0.009770863,-0.10412593,0.019978765,-0.0033638203,-0.02560761,-0.008845107,0.05603012,0.027231375,0.004398891,-0.014811585,-0.028703595,-0.058412526,-0.034354772,0.049811848,0.08420955,-0.08321541,0.028945059,0.14191692,0.05413704,0.019705674,-0.09823439,0.021680592,-0.011252703,-0.03556873,-0.045681316,0.033961795,0.004008208,0.013659023,-0.02782604,-0.04232948,0.15877137,0.025140736,-0.025278954,0.08340475,-0.022962356,0.062023424,0.08259428,-0.031834994,-0.06612898,-0.045960963,-0.013795891,-0.023788724,0.025122538,-0.03178903,0.0002250121,0.021438269,-0.016782997,-0.03941279,-0.070586294,0.011878388,0.003649771,-0.02550882,0.06599023,0.046866953,0.0485325,-0.04950292,0.057594128,0.028304763,-4.3545857e-08,-0.0053528836,-0.060270473,0.075195074,0.016298635,-0.018183563,-0.022959124,0.026995948,0.008950808,-0.021099266,0.012522772,0.037425403,0.06226579,0.049003027,-0.024206994,0.0641182,0.028684668,-0.04618716,-0.012157765,-0.05382034,0.0134765925,-0.07163702,0.011570534,-0.060179424,-0.071477175,0.0009628241,-0.028845275,-0.035174247,-0.030198481,0.018344026,-0.0057809353,-0.0128010735,0.025025208,0.010366955,-0.032997057,0.009573134,0.029937217,0.042068876,-0.0273191,-0.11691332,0.054275583,0.06462395,-0.03821892,-0.10300837,0.056914844,0.024313657,0.021930328,0.02481649,-0.03429937,-0.025308847,-0.026735239,0.055572297,0.046809234,0.10104582,-0.016795712,-0.097643055,0.006632181,-0.0681132,-0.05154328,-0.064447746,-0.078841105,0.06404397,-0.017410934,0.13984634,0.09795156 +1.1.99.24,4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor.,384,1.0,-0.012208517,-0.034824874,-0.03937334,-0.036991358,0.018867625,0.024801552,0.018231612,0.043922637,-0.038912047,-0.029601552,0.011833509,-0.0861826,-0.047323637,0.11337089,-0.038358275,0.12696467,-0.024013966,0.05187464,-0.042939425,0.047088373,0.02688619,-0.049226917,0.015748028,-0.035735082,0.004193118,0.050699737,-0.0052291728,-0.048527762,0.046543423,-0.064419836,0.015541526,-0.012378327,-0.01330855,-0.027513677,-0.039270204,0.04154118,-0.060028397,-0.023180198,0.026316023,0.08232149,0.053053368,-0.048617408,0.049232334,0.039012965,-0.04156289,-0.001883252,0.040032916,0.048853107,0.041814752,-0.039266545,0.013671719,-0.019927358,-0.112358436,0.13755861,-0.008855049,0.015500805,-0.063183255,-0.018558603,-0.015980653,0.035191216,0.026949955,0.013100679,-0.01097611,-0.024950374,0.032648064,-0.020381557,-0.0014893741,-0.00054961,-0.005292625,-0.030477593,0.013450154,-0.013270764,0.074597776,-0.008876376,-0.0048197424,0.020299174,-0.038054693,0.011782186,0.040720955,0.013787409,-0.023479179,0.006722801,0.020174133,0.052375063,0.03056346,0.012472167,-0.0652632,-0.038296945,-0.022377372,0.08602257,-0.010883966,0.044368714,0.056311388,-0.046452675,-0.03506847,-0.037125137,0.06790934,-0.010261248,0.056932107,-0.00124669,-0.03572526,0.044001613,-0.0804212,-0.07538016,-0.06969449,-0.04820992,-0.029917441,-0.0027444495,0.044665232,0.0155066345,-0.07398181,-0.04221108,0.03419626,0.024260746,-0.06368053,0.09983594,-0.059807118,-0.108841814,-0.096660234,-0.10822492,-0.04918836,0.008695075,0.099468015,-0.07945243,-0.015518398,-0.015892321,-0.067053586,2.558938e-33,0.039560203,0.021759342,0.0276513,0.037273183,-0.041030493,0.031068573,-0.07806073,0.00038325845,-0.0028548224,-0.06949019,-0.092513226,-0.043108672,0.06333824,0.096146576,-0.079863675,-0.020519132,-0.038279213,0.0046640243,0.023105439,0.018341681,0.021182252,0.096532136,-0.05495852,0.05064216,-0.031872503,0.022277346,-0.0020696123,-0.0016590245,0.063899815,0.010775657,0.04393822,-0.0045682574,-0.078634575,0.0040922905,-0.03188098,-0.042335108,-0.0173638,-0.052953288,-0.045534637,-0.016285213,-0.035184134,-0.01585122,-0.019883525,0.012562546,0.13782752,-0.052745607,-0.01298454,-0.02742259,0.022969717,0.101245716,0.010311785,-0.025468014,-0.007071769,-0.048589442,-0.04293021,-0.041897297,-0.024893256,0.062816285,0.0031537244,-0.0163146,0.027509002,0.12962593,-0.03822392,-0.040318534,-0.05701102,0.052300714,0.010590292,-0.088895656,-0.045476135,-0.0030490179,0.012078665,-0.057238497,0.031234821,0.109506756,0.043731567,-0.060961533,0.011399697,0.028551877,0.080453426,-0.053089734,-0.05029579,0.00064224313,0.09228246,0.036762275,-0.06699374,-0.027714433,0.037578672,-0.09086126,0.04083078,0.026645098,0.035895746,-0.08368127,-0.071854346,-0.08534475,0.061587945,-3.587304e-33,0.09380207,-0.056459915,-0.038540725,0.021175036,0.026690634,0.0089485375,0.031155737,-0.03352273,0.12434552,0.02389442,0.101818964,0.021430017,0.049395226,-0.0009646035,0.10399893,-0.06290734,-0.043114066,0.020766519,-0.059701566,-0.018875541,0.0545498,0.0556636,0.014214394,0.022923568,0.048939098,0.029432384,0.03977809,-0.056831837,0.108883575,0.031664114,-0.026404288,0.016257465,-0.0382015,-0.06463769,-0.012147773,0.021071356,-0.036774352,0.023539515,-0.09957534,-0.022127314,-0.024353212,-0.039879944,0.05411401,0.12509769,-0.0032211014,-0.020784112,-0.05025739,2.2416736e-05,0.06841441,-0.035384588,0.0016762549,0.030912533,-0.027014034,-0.02182345,0.08634829,0.035250727,0.012037704,-0.05434403,0.06254273,-0.064672194,-0.05101811,-0.08157321,0.0877188,-0.007051965,-0.0038112625,0.012035597,0.0667411,0.049479913,0.01957284,0.0039455965,0.10580696,-0.02484523,0.06780566,0.0017850954,0.043829966,-0.073689744,-0.07623275,-0.041328818,-0.04026875,-0.035220873,-0.048653435,0.031562317,0.097039014,-0.027220637,0.04765681,-0.13372098,0.02054175,0.05100161,-0.029347984,0.037034277,0.006198648,0.020382082,-0.037511233,0.061667778,0.08822889,-3.5863845e-08,-0.01456842,-0.0070731496,0.0644948,-0.0015635769,-0.05680584,0.0044511757,-0.05669821,0.02097171,0.009984948,-0.040972672,0.018235236,0.11607994,-0.006425865,-0.016315155,0.061737258,-0.087930694,-0.021597441,-0.009420902,-0.07497813,-0.012688179,-0.12785251,-0.04678368,-0.020922212,-0.01760273,0.010746888,0.015868334,0.04696346,0.0058772177,0.016210547,0.008794775,0.08534608,0.0749832,-0.008164899,-0.029062515,-0.05334607,0.037114542,0.032108326,0.018959561,-0.04509335,0.006903504,-0.029673787,-0.078624964,-0.06980272,0.08064708,0.060031828,0.03141565,-0.06724796,-0.025086725,-0.02038615,-0.043365028,0.020097366,-0.056021966,-0.014648035,-0.016273119,-0.06612273,0.0501546,-0.024111375,0.002986085,0.03834047,-0.06272918,-0.02895907,0.017714487,0.14547916,0.025881218 +1.1.99.26,"2,6-Dichloroindophenol and methylene blue can act as acceptors.",384,1.0,-0.054858703,-0.09834019,-0.007014993,-0.00460542,0.09029701,0.024766486,0.07632922,0.01671994,0.042492595,-0.02087467,0.040177137,-0.014296385,-0.053023987,0.01290838,0.025162091,0.18261681,-0.08269055,0.01282222,-0.09112722,0.06436492,-0.015592531,0.010528147,-0.01824749,0.018825667,-0.1003342,0.044530474,0.027080681,-0.0023550312,0.018543229,-0.018529544,-0.03457427,0.05184302,0.01827779,0.031131454,-0.0164156,-0.04490799,-0.014669339,-0.02739644,-0.030557062,0.03399521,-0.0012713586,-0.03007914,0.013039935,-0.04467072,-0.03079406,-0.043796603,-0.0072748447,0.05653422,0.042597055,-0.084642105,0.05481021,0.05022361,-0.056945797,0.09904177,-0.03572165,0.07658389,-0.099852145,-2.0007377e-05,0.022255411,0.019094205,-0.017743124,-0.018067744,-0.0051938416,0.0032927173,0.03322508,0.0123007,-0.037236787,-0.0018896259,-0.03175962,-0.009188734,0.005925808,-0.013218872,0.03551335,-0.02310057,0.0895056,0.05098327,0.022205945,-0.036012676,0.0132073825,-0.06574595,-0.063918695,-0.063372985,0.06480302,0.099509604,0.07459811,-0.011937691,-0.059453927,0.062461264,-0.07522297,0.074219935,0.017416123,0.03852034,0.043400306,-0.09044989,-0.055521347,0.031178191,0.034319796,-0.03911169,0.041715518,0.02498375,-0.014450343,-0.0059995367,-0.11816566,-0.081928164,-0.0084578395,-0.0017199465,-0.01682836,-0.003107095,0.06012295,-0.018078351,0.029087473,-0.08250938,0.10678343,0.039732836,-0.06336016,0.04956513,0.022346053,-0.027280167,0.013104147,-0.079603255,-0.01646075,0.01236425,0.03302108,-0.03860443,-0.09228129,0.034569606,-0.037002232,2.6405295e-33,0.018102478,0.02985427,0.055570282,0.038118213,-0.05059048,0.046186626,-0.076410376,0.014769224,-0.006054129,-0.14231212,-0.056195725,-0.029534854,0.026523737,0.04581965,0.039263092,-0.053877927,-0.013727923,0.05816173,0.04766619,-0.02233541,-0.037638377,0.06608526,-0.091130115,-0.02727855,-0.014511029,0.028783267,-0.01842082,0.037153713,0.074792095,-0.01788708,0.043510932,0.03784877,0.0012176542,0.064475864,-0.052417737,0.059344742,0.0015058022,0.027525362,-0.007400012,-0.084102154,0.015043268,0.033555374,-0.10973432,0.06583873,0.039895244,-0.013029715,0.047125377,-0.06981073,0.01606382,0.052829556,-0.0923523,-0.0077227186,0.009435556,-0.08757656,0.010528017,-0.0116599435,0.026411915,0.02270257,-0.008731804,0.03396252,-0.013449007,0.09713403,-0.009986734,-0.009451792,0.0065450943,0.007863914,-0.0706033,-0.050356705,-0.06377847,-0.029912217,-0.04997509,0.013342184,0.047881655,0.016017346,0.04363438,-0.05944405,0.019738168,-0.043992788,0.013280989,0.006682542,-0.044092014,-0.061900053,0.059140433,0.051571056,-0.147846,0.023241546,0.013169502,-0.09482845,0.043980993,-0.020879656,0.07361293,-0.09634973,-0.075272076,-0.03027764,-0.020563653,-3.3117805e-33,0.00051946053,-0.05137572,0.022923535,0.05932965,0.069804005,0.018980272,0.029619535,-0.063734055,0.09664336,-0.040224344,0.12888311,0.065994285,0.04867146,-0.013503118,-0.0068124956,0.008528811,0.020868627,0.11780765,-0.008460618,-0.020664616,-0.032872405,0.014206037,-0.021250509,0.088175885,-0.015258302,0.09712277,0.030487593,-0.085193984,0.08255658,0.04139286,-0.03819188,0.063803196,0.005303037,-0.00082441483,0.106426366,-0.013102245,-0.074062526,-0.066198766,-0.08031238,0.06555348,-0.059824288,-0.066741616,-0.036696665,0.059874132,-0.026490934,-0.028076638,0.03982495,0.014160369,-0.032794837,-0.041923176,0.020228783,-0.0016835562,-0.05522262,0.026064163,0.06961155,0.004681177,0.058521733,-0.05559638,0.029642805,0.03144598,-0.0066471677,0.015386918,0.024909329,-0.03163577,-0.011385067,0.0045223534,-0.02901887,0.100061804,0.033347692,-0.06520981,0.10417657,-0.04384332,0.084029615,0.038677365,0.023690445,-0.11404994,0.008393988,-0.07980078,-0.05148691,0.024093734,-0.10027793,0.05505882,0.024258811,-0.0016686593,-0.010240515,-0.059446692,-0.00035028422,-0.04084595,-0.09458332,0.013174407,0.010756278,0.047017828,0.010459178,0.10308578,0.031694297,-2.8028238e-08,0.031167412,-0.12432479,0.078237474,-0.047715157,-0.06466935,-0.007228238,0.047359798,0.012361324,-0.019365964,0.03083859,-0.0059597143,0.012281215,0.03546947,-0.036075793,0.022202156,0.009195204,-0.0332413,-0.076701805,-0.05937468,0.003652662,-0.081890315,-0.016892202,-0.037756328,-0.06557177,-0.0034479315,-0.0061837193,-0.017322307,0.028622003,0.07422161,0.02049523,0.06953575,-0.009917656,-0.027899755,-0.0038117885,0.029451571,0.047950327,-0.031943284,-0.0401966,-0.08754643,0.059913166,0.017654946,-0.09004135,-0.08970608,0.04348452,0.03326094,-0.040840056,-0.030904356,0.03696375,-0.020652534,0.025681911,-0.0015179615,-0.019285059,0.040712647,0.01551371,-0.040032875,-0.002433449,0.0027215218,0.01755238,0.02242794,-0.042150363,0.006185631,0.0029765316,0.11243195,0.038843296 +1.1.99.27,"High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.",384,1.0,-0.047741182,-0.0155905755,-0.1036203,-0.06866769,0.001947702,-0.021161651,-0.05507123,0.09263578,0.042958844,0.017729938,-0.03838708,-0.039724123,-0.05902562,0.085901365,0.0009732964,0.0010132967,-0.018713536,-0.071492724,0.00526406,0.07764386,0.06322497,0.08525329,-0.02570955,-0.027284933,-0.058343824,0.09947438,0.00660646,-0.05370554,-0.019130634,-0.07402417,0.0055217394,0.040780608,0.061704814,-0.0026817701,0.06134437,0.020010144,-0.049718104,-0.004645982,-0.032265738,-0.0074066306,0.040912557,0.04374729,0.052280083,-0.051054116,-0.019112775,-0.034430623,-0.015716031,0.022008164,-0.0067385463,-0.013047091,-0.069801085,-0.05120178,-0.02630958,-0.009889549,0.003541606,0.0053049014,-0.0894724,-0.052506503,-0.002833441,-0.06396329,0.008413946,0.029473774,-0.04393304,0.012392442,0.038933005,-0.08158512,0.042607486,-0.042955883,0.08234494,0.015120467,-0.05665966,-0.023580223,0.06605274,-0.030721307,0.0315015,0.06259498,-0.0031068982,0.024073057,0.03649377,-0.069729194,-0.011807333,-0.019226866,-0.029957894,-0.0026206132,0.01725133,0.026127981,-0.024959806,0.04787169,0.10852565,-0.018851811,0.018789439,-0.013793701,0.012486446,0.0036639455,-0.14701533,-0.014251742,-0.01951581,0.07441837,-0.050071668,0.015504053,0.0677199,0.051696293,-0.1148283,-0.027696943,-0.08425892,-0.026662197,0.12329479,0.02844216,0.030076047,0.037747532,0.030722702,0.0017767726,0.079009704,-0.07074613,-0.019055994,0.04379945,0.021598836,-0.094815664,-0.018304667,-0.054133702,-0.03589829,-0.13090758,-0.0067404145,-0.06150714,0.009712756,0.096698776,-0.10524797,8.014369e-34,0.0947817,0.04464741,0.08606769,-0.03870273,-0.0493963,-0.06574872,-0.046739623,0.020204987,-0.04203198,-0.07027607,-0.091278456,-0.038827717,0.0011654898,0.02138607,-0.103287816,0.033090707,0.060086064,-0.03943453,0.07961931,-0.044464126,-0.0023924033,0.078264475,-0.039785013,0.0662812,0.04298027,0.031777557,-0.010733613,-0.011891323,0.04564068,0.0014321201,0.1189284,-0.077098794,-0.04045092,0.08015057,0.035922907,0.090647265,-0.094790265,0.029271254,-0.06096088,0.047474463,-0.026629357,-0.042132106,-0.038239762,0.044942472,0.038235933,-0.05627874,-0.07105553,0.09763513,-0.00607619,0.050510094,0.0401253,-0.012272763,0.066445865,0.053579614,-0.052409984,0.07965462,-0.011290841,-0.011703707,0.07979038,-0.029516676,0.034356933,0.058246065,-0.058746677,0.018254088,0.0147423465,0.06567366,0.0070609953,-0.05093934,0.040216565,0.058445062,-0.019665835,-0.033239268,-0.0033683563,0.15883246,0.036022723,0.03192094,-0.009930363,-0.0029608388,0.023024824,0.008890624,0.07246213,-0.022520788,0.040503856,0.01873975,-0.10086637,-0.022421282,0.010107803,-0.006105147,-0.034797587,0.0009946175,0.12003395,-0.07831552,-0.015621241,-0.009596001,-0.010714035,-1.2091821e-33,0.042424586,-0.052374847,0.007395943,-0.042051636,-0.03467201,0.037023477,-0.029876977,-0.0638378,0.03470187,-0.07094366,0.07805286,0.029923383,0.061428193,-0.064944595,0.051464837,0.019937685,0.01878828,0.0077874474,0.007825407,0.014020254,-0.0538696,0.060511455,-0.0052712336,0.050500173,-0.037028324,0.055603303,0.03709714,-0.0042611547,0.02024912,0.017320465,0.018479927,0.0881128,-0.061621506,-0.113696724,-0.05472874,0.02271747,-0.061080933,0.015613428,-0.038584866,-0.04724597,-0.04651248,0.056824908,0.096823126,0.05864653,0.032132614,-0.008896095,-0.026325254,-0.017597916,-0.0028223114,0.010749322,-0.038540408,0.01183988,0.014219401,-0.055029277,0.12587628,0.058119923,-0.0059936885,-0.031354893,0.05100017,-0.077318706,-0.0053545083,-0.11214781,0.00927456,-0.0036851151,0.05044755,0.06168961,0.02224091,0.08908133,0.035353407,-0.0011819603,-0.0008066084,0.039463505,0.009858891,0.049539283,-0.08100744,0.017266331,-0.061782926,-0.0028088193,-0.0062503,0.018636474,-0.02825884,-0.039464116,0.07091346,-0.11689623,0.0091371015,-0.038236048,0.07615799,-0.033709496,-0.005631489,0.03220424,-0.018598406,-0.013524374,-0.0012805752,0.023932595,0.007931798,-3.8573965e-08,0.0914646,-0.12724684,-0.0020675359,-0.035471853,-0.0650506,0.021005478,0.021301148,-0.028178882,0.0271642,0.038713034,0.0012794613,0.05380521,-0.011517056,-0.026284087,0.0012835148,0.051612683,-0.018668469,-0.023075402,-0.101145975,-0.037991945,-0.01796293,0.0098031415,-0.06841553,-0.007158255,0.12164569,-0.04103713,0.02748151,-0.024817852,-0.018321838,-0.04539344,-0.045599584,0.029354252,0.061070867,-0.013527795,-0.06031016,-0.019247394,0.07741886,-0.010161529,-0.047164783,0.042966805,0.055850416,0.020504719,-0.044503745,0.010011596,-0.045479447,0.010699119,0.03364692,0.036125287,-0.07155888,-0.04658882,0.0024731308,0.041943535,-0.005180951,-0.019460216,-0.10152895,-0.013526162,0.016500693,0.058306877,0.0046900217,-0.029070819,0.015358346,-0.025885755,0.0867284,0.038460806 +1.1.99.28,"D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. The ketose substrate must be in the open-chain form. The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. The enzyme from Zymomonas mobilis contains tightly bound NADP+.",384,0.99999994,-0.0026429272,-0.023745539,-0.020132693,-0.006169352,0.014307745,0.00873036,-0.07153715,0.05566053,0.00866178,0.010674483,0.020313235,-0.0020219705,-0.02842484,0.061873168,0.00041892016,0.036810588,0.032893673,0.012645829,-0.027976882,0.02329639,0.14412194,-0.00037843184,0.049964663,-0.043009493,0.09172931,-0.04339421,0.021895543,-0.015872477,0.0063782884,-0.083384514,-0.07099773,-0.03135694,0.032218907,-0.04900988,0.06025332,0.11856421,0.045465194,-0.029548228,0.04388428,-0.03464201,0.026877983,-0.030220937,-0.012788557,0.0061894488,-0.06905543,-0.015557102,-0.0077408627,0.0730574,-0.023676302,0.057213485,-0.06846337,-0.11347547,0.013239282,0.017817577,0.05109632,0.029243398,-0.022945784,-0.005300272,-0.04231711,-0.0015664122,0.03181624,0.017636351,-0.040160686,0.028585425,0.01687114,-0.07409555,0.009044605,-0.057437517,-0.051327076,-0.040730976,-0.032776166,-0.05059032,-0.047908034,-0.0085960645,0.026087344,0.008241397,-0.02609123,-0.12805282,0.008928279,0.044819456,0.07094384,0.053793166,0.08435183,0.04611604,0.03629369,-0.039979104,0.02604503,0.02680961,-0.03964562,-0.029365715,0.00047343672,-0.025687208,-0.017998818,0.040813528,-0.05424159,-0.013398248,0.012823914,0.021817436,-0.017014666,-0.0180481,0.056877524,0.019889629,0.05084795,-0.031498354,-0.07499912,0.04958734,-0.01976699,0.082533665,-0.085207246,0.001204772,0.001962537,-0.018573273,0.02541067,-0.016382417,-0.097301625,0.06270046,0.004898658,-0.08056122,-0.0669579,-0.042283263,-0.024116391,0.009490955,0.067793734,0.05771845,0.009570942,0.0721051,-0.07155599,3.629807e-33,0.07623768,-0.033649653,-0.021211939,-0.06599203,0.017666688,0.010577846,-0.015858306,0.01882743,-0.0639637,0.03639837,-0.099554725,-0.011433015,0.0211635,0.058509007,-0.019235538,0.015520871,0.018280871,-0.038834553,0.058682892,0.08099254,-0.007988523,0.033240072,-0.009190281,-0.0054391827,0.0718983,0.042579185,-0.01831797,0.031584423,-0.034712277,-0.0077576763,0.033778097,-0.09785041,-0.115355305,0.0023560864,0.04536668,0.050874382,-0.08002661,0.021434084,-0.046157934,0.0065704845,0.0020209646,0.02663203,0.055885337,-0.07136008,0.021610275,-0.0059425477,-0.021607751,0.009290639,-0.013083765,0.061852872,0.0838827,-0.019912364,-0.021923207,0.074733555,-0.09628475,0.030674435,-0.05717733,-0.023769172,-0.01792191,0.052311607,-0.0088351555,0.007848338,-0.012154718,0.03842299,-0.007818891,0.037157554,-0.089584626,-0.061218336,-0.025753519,0.09110708,-0.057374604,-0.04972977,0.062351678,0.004637852,0.022379128,-0.05361945,-0.05856929,-0.024652421,0.053937964,0.023963101,0.09898694,-0.013423384,-0.04133318,-0.042341623,-0.143171,-0.025571333,-0.032744315,-0.04923964,0.0025120832,0.047959927,-0.07686624,-0.02626361,-0.038289204,0.026617086,0.01634738,-5.5151095e-33,0.11917495,-0.06154159,0.12448152,-0.086536914,-0.01902201,0.062032294,0.08203322,-0.058503684,0.039080616,-0.047746804,0.07097322,0.032951996,-0.03052657,0.007495718,-0.011189348,0.013550967,-0.0943791,0.071134545,0.02437532,-0.028351845,-0.035582904,0.14417072,0.0040772003,0.017250333,0.07973277,-0.038649686,-0.010557984,0.03949405,0.08722638,0.025224762,-0.021629885,0.010910587,-0.02196085,-0.04513895,-0.035673272,0.05797582,-0.12639691,0.017808687,-0.02019588,0.045073703,-0.015930472,0.087935805,0.004808442,0.011778153,0.04340152,0.046437707,-0.09929327,-0.080368444,0.03629687,-0.014088346,0.011427642,0.006025049,-0.029442212,0.027493542,0.04169666,0.10511052,-0.002553661,0.046676192,0.03185451,-0.04761247,-0.05205621,-0.04964205,0.06152878,-0.060253635,0.09089956,0.0019939812,-0.006587865,0.023283314,0.0061396365,0.0904632,0.07313516,0.00047372884,0.016232288,0.031192329,-0.02555913,-0.0019923018,-0.16300274,-0.0074308496,-0.023717562,-0.002635484,0.05387189,0.015139962,-0.032921515,0.011726293,0.026716942,-0.03857337,0.052901242,0.04410359,-0.011466603,0.01325587,-0.0043230015,-0.017651208,0.005195837,0.029571887,0.032762565,-4.2739522e-08,0.044802543,-0.05517316,-0.0042324653,-0.041664153,-0.029242648,0.012992731,0.0696589,-0.027306074,0.033885032,0.027317625,-0.026223665,0.17422782,-0.003746499,0.033376127,-0.019269153,-0.023169806,-0.05184021,0.0053867213,-0.011584143,-0.017037652,-0.0910101,0.008742364,-0.1258389,0.04009515,-0.0039303266,-0.060839977,0.021648867,0.03179791,0.037045036,0.016840152,0.013049237,0.079427175,0.07157188,-0.075441,-0.051903713,0.009358621,-0.10671808,-0.030019062,-0.051509403,-0.018417051,0.006687675,-0.08719775,0.034991294,-0.0147144925,-0.0012975143,-0.06463111,0.06041787,0.018290164,-0.01713536,0.07204095,0.02367764,0.030364098,-0.08381748,-0.078247674,-0.033296894,0.0149824,-0.027232293,-0.026396146,-0.04142006,-0.069769755,0.03243093,-0.053151656,0.15904438,-0.104727335 +1.1.99.29,"Requires FAD. A number of aldoses and ketoses in pyranose form, as well as glycosides, gluco-oligosaccharides, sucrose and lactose can act as a donor. 1,4-Benzoquinone or ferricenium ion (ferrocene oxidized by removal of one electron) can serve as acceptor. Unlike EC 1.1.3.10, pyranose oxidase, this fungal enzyme does not interact with O2 and exhibits extremely broad substrate tolerance with variable regioselectivity (C-3, C-2 or C-3 + C-2 or C-3 + C-4) for (di)oxidation of different sugars. D-Glucose is exclusively or preferentially oxidized at C-3 (depending on the enzyme source), but can also be oxidized at C-2 + C-3. The enzyme also acts on 1->4-alpha- and 1->4-beta-gluco-oligosaccharides, non-reducing gluco-oligosaccharides and L-arabinose, which are not substrates of EC 1.1.3.10. Sugars are oxidized in their pyranose but not in their furanose form.",384,1.0,-0.00046205643,-0.08489649,-0.07341809,-0.003352088,0.09899783,-0.015804002,-0.039681584,0.022054346,0.04530633,-0.0036155556,-0.012135207,0.04007603,-0.12556207,0.06545736,-0.07734004,0.05490013,-0.0024849148,0.016623292,-0.005669238,0.008698895,0.107639134,-0.08198401,0.026364148,0.004391636,0.05701544,-0.04402306,0.02326662,0.035098486,-0.07106666,-0.08628366,-0.06689008,-0.07925638,0.037713207,-0.01911481,-0.04950081,0.077895686,0.001320919,-0.059867986,-0.029203543,-0.0061007463,-0.037157696,-0.050850675,0.003451336,0.012155837,-0.034868475,-0.072411105,0.0063869585,0.02813743,0.015507896,-0.019520544,-0.029929304,-0.07784857,-0.047759384,0.019499991,0.043685883,0.070863076,-0.018130286,-0.012033355,0.006139052,-0.024609322,-0.0067107272,0.0203437,-0.008528359,0.04985155,-0.0547457,-0.018019678,0.019494409,-0.0727465,-0.07518967,-0.017375141,-0.04876598,-0.060282987,-0.059318483,-0.02824373,0.10493517,0.05491195,-0.03245757,-0.034820836,-0.010621104,0.010018535,0.029583061,0.047050513,0.04177373,0.008258564,-0.0053452323,-0.08123647,-0.0118471505,0.042710707,0.042734966,-0.025756033,-0.00012861947,0.03926032,-0.020276513,0.010664715,0.005495482,0.020087516,0.13557108,0.070933454,0.0488838,-0.021215314,-0.030917523,0.037818074,0.0005281408,0.014659571,-0.05761992,0.051057167,-0.010493283,0.062722266,-0.00097560574,0.00894903,0.0061909333,0.01702714,0.030143073,-0.01484454,-0.052986603,0.011345111,0.018417226,-0.097955614,-0.038612995,0.039641272,0.0012308845,0.03708363,0.07189163,0.009052939,-0.0023938643,0.063026786,-0.03623895,3.8714462e-33,0.07667084,0.0039125616,-0.02312255,-0.050839763,0.039416675,-0.013530202,-0.06895107,0.0026811142,0.003742052,0.02978616,-0.10579522,-0.033548582,0.039924737,0.06741257,0.039199855,0.07940593,0.04518373,-0.049690165,0.077855855,0.04785712,0.035949565,0.008714786,-0.04667995,0.044162843,0.06734997,0.04999507,-0.01894388,0.0920628,-0.0060523385,-0.018630115,0.083166115,-0.056782007,-0.08426942,-0.018076424,0.023806363,0.021676596,-0.068825044,0.012982784,-0.03898224,-0.021791827,-0.010936376,0.034667578,0.01887294,-0.049118854,0.051713414,-0.061397877,-0.003532842,0.06408816,0.020276694,0.11123171,0.0415332,-0.025322525,0.015352706,0.09174194,-0.027949598,0.014417245,-0.041993767,-0.03709179,0.019974248,0.0252977,0.026072698,0.039266698,0.02566167,0.022200536,-0.0058464557,0.035357714,-0.07098437,-0.005512109,-0.06260323,0.031751014,-0.0604557,-0.028700512,-0.035933655,-0.0047202287,0.008269175,-0.06523945,-0.000925528,-0.054723684,0.051713854,-0.0323012,0.005200631,-0.033636577,0.03105041,-0.024610365,-0.11316902,-0.0067585614,-0.05056646,-0.009803113,0.0035601086,0.02992757,-0.039293546,-0.029084364,-0.062097743,-0.011595358,0.07083405,-6.151309e-33,0.16426557,-0.07370372,0.12057118,-0.08957414,-0.017168013,0.07088445,0.012550317,-0.028730072,0.051776435,-0.07741242,0.026985975,0.029738232,-0.006816508,-0.049406387,0.0199856,-0.0059688636,-0.14302403,0.09256374,-0.006056321,0.03345108,-0.007032568,0.12779428,-0.051168565,-0.02359328,0.08344859,-0.037392512,-0.03478948,0.00871381,0.052871946,0.023318842,0.0051010232,0.029184353,-0.010071763,-0.05465479,0.026590046,0.05736422,-0.062654786,-0.00056787377,-0.00046928783,0.116613366,0.02689813,0.07320581,-0.009085915,0.020817764,0.030324327,0.075641945,-0.1273857,-0.010711725,0.047179993,-0.07872688,0.003626325,0.021215567,-0.025429444,0.028182982,0.124283,0.059615765,0.05657109,-0.007056047,-0.0068403087,-0.07823452,-0.038960885,-0.079162754,0.04324564,-0.045970887,0.056990255,0.017493265,-0.05860785,0.05090918,0.034575447,0.07408264,0.036492467,-0.029086635,-0.020527279,0.020449022,-0.02970577,-0.04237943,-0.10966893,0.055112604,-0.01463201,0.02635456,0.07029997,0.0042848857,0.04666237,-0.023455182,-0.022547746,-0.074046515,0.034921613,0.04092312,-0.025155876,0.013325015,-0.016273659,0.0036831181,0.011528485,0.029070405,0.0804328,-5.2724193e-08,0.005955907,0.018685414,0.021993462,-0.032101676,-0.022154497,-0.004435984,0.00747508,-0.011636294,0.009026897,0.0031867432,-0.03978583,0.16752711,0.014963811,-0.024818698,0.022372209,-0.026129061,-0.041427143,0.00016978745,-0.011036917,0.079022594,-0.1289829,-0.027387233,-0.16643646,0.027059214,0.017345533,-0.084311694,0.04744852,0.021978503,-0.03040382,0.035788577,0.0476141,0.038733367,0.022803942,-0.072263144,-0.07929974,-0.012627277,-0.04361309,-0.046632424,-0.0025830574,-0.045877893,0.0036949138,-0.09134578,-0.01826638,-0.03860294,-0.0076090647,0.0026601336,-0.02403083,0.0051314374,-0.07042415,0.029076606,0.046298154,-0.033544637,-0.08069577,-0.06339933,-0.054274313,0.007431708,0.013190704,0.018019982,-0.0056560114,-0.10327665,0.061246544,-0.041818958,0.15501225,-0.07448547 +1.1.99.30,"Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.",384,1.0,0.057648357,-0.10287215,-0.12213792,-0.026118748,0.101287015,0.02468309,-0.017903151,0.023740036,-0.021637727,-0.016089745,0.030771447,0.0074221254,-0.11305071,0.07536831,-0.05771544,0.0760234,-0.051828194,-0.031567283,0.040016964,-0.010626865,0.036511563,-0.04608318,0.024069026,-0.010663989,-0.017480543,-0.010798782,0.03502126,-0.0032742086,0.016456183,-0.022120537,-0.036416348,0.00854537,0.037077576,-0.04158236,0.024118545,0.05475166,-0.039020076,-0.093056805,0.05041715,0.008258767,0.043202564,0.08953554,-0.01743847,0.031017816,0.01182617,-0.023421591,0.02088951,-0.029100295,0.05373826,0.040356055,0.0479681,-0.06720785,-0.05336845,0.050563645,-0.014332681,0.022674268,-0.05206766,0.0024654018,0.06845403,0.06576206,0.054913595,0.027072169,0.08598215,0.035422646,0.06991852,0.003785825,-0.010430671,-0.008256051,-0.051258594,-0.06118337,-0.05630949,-0.0004213079,-0.033830445,0.0005827491,0.021227589,0.028479949,-0.005177123,-0.09476073,0.015746905,-0.006914523,-0.0074874475,0.04360141,0.0138202775,0.025872275,-0.012702332,-0.033767086,0.025683772,-0.010765001,-0.032090493,-0.07749724,0.029883828,-0.011040542,-0.026124548,0.026367424,-0.04808038,0.0059882873,0.0402449,0.038800888,-0.0668036,0.012421004,-0.08360297,0.03224242,-0.0117836865,-0.021023525,-0.1062982,0.03729881,-0.004056127,0.08100983,0.032688662,0.08267819,-0.03085329,0.020125784,0.010638094,0.012139724,-0.00449673,0.019726511,-0.04570975,-0.026235322,-0.028150178,0.03229149,0.047529537,0.01963259,0.05440731,-0.00030235772,-0.063999414,0.04946894,-0.039732374,4.103174e-33,0.07524799,-0.03206046,0.10028317,0.009913617,0.09991519,-0.01416906,-0.06867445,-0.0400928,0.0074725323,0.016885059,-0.037948377,-0.10031211,0.08487817,-0.02175029,-0.00365506,-0.05586707,-0.01010156,-0.019033372,0.07790837,0.052559126,0.0040378706,0.06695598,-0.047603827,0.0033168886,0.07795099,0.01364895,-0.03608381,0.07101342,0.08034228,0.0059993733,-0.0042744363,-0.07395331,-0.12875344,-0.027456582,0.074196145,-0.08063767,-0.050247457,-0.071307085,-0.055745073,0.01072003,-0.060571063,-0.03636395,-0.012072334,-0.072041795,0.08892733,-0.10095891,-0.030093895,0.086648785,-0.020733573,0.03137037,0.027730148,-0.0517767,0.033337377,-0.021051357,-0.05194941,-0.023555117,-0.07486735,-0.032592986,0.073133186,0.019719075,0.026168576,0.007640148,-0.060307354,0.04255053,0.018151019,0.041617215,-0.13192677,-0.038806655,-0.01480641,0.0302016,-0.04815635,-0.0023293253,-0.012689424,-0.048570685,-0.026723206,-0.03402078,0.0053620897,-0.05431164,0.0040582484,-0.039950177,-0.007730234,0.02291257,0.01416623,-0.03912915,0.005762499,-0.018966263,-0.10203191,-0.060282756,0.023992313,0.053685002,0.023913873,0.045230266,-0.098922655,0.02422053,0.0033848942,-4.9577925e-33,0.08268975,-0.053096958,0.058934294,-0.13131422,-0.03761811,0.08389944,0.049976744,-0.009069838,-0.0017489259,-0.0836488,0.017254127,0.044497672,-0.055479117,-0.06498896,0.0449984,0.06312774,-0.036734737,0.13504618,0.02531698,0.020091321,0.06889228,0.08076629,-0.02979295,-0.011320225,0.05126995,0.022797458,-0.014333862,0.051506285,0.110757336,0.06358528,-0.005844552,-0.020733006,-0.021520777,-0.020704903,-0.005931073,0.008336576,-0.035090562,0.0029078485,0.026144713,0.014119034,-0.021948919,0.08210132,0.016950661,0.07188022,0.040962838,0.064485155,-0.08938746,0.03414759,0.03663954,-0.023313513,-0.049199384,-0.07485134,-0.07733299,-0.0017054428,0.07042376,0.054770105,0.02373433,-0.0005397261,0.03974234,-0.028832616,-0.02928838,-0.06774103,0.008385979,-0.0005455615,0.077698074,0.040106833,-0.045841113,0.07241896,0.08652181,-0.03649101,0.07648533,0.046242326,-0.07421556,-0.0120083485,-0.040439837,0.02439026,-0.07440219,0.009116335,0.017254839,0.06355312,0.015210275,0.022887126,0.0066550807,-0.08895232,0.04735243,-0.06364941,0.0076000243,0.08195755,0.03170936,0.0032355664,-0.010469941,-0.061180826,-0.01832195,0.00780708,0.024437184,-4.380322e-08,0.020238806,-0.017582705,0.07349358,-0.057747554,-0.0047950344,0.010392825,0.04782683,-0.03487385,0.005825511,-0.06685333,0.023001576,0.053445246,-0.0031469122,-0.022515763,0.08520081,0.012474864,-0.06427373,-0.0062201354,-0.035326026,0.06323363,-0.072192945,-0.0518594,-0.107386395,0.10888532,-0.07934704,-0.09976245,0.039953906,0.089908384,-0.046287566,0.04705912,0.011049824,0.038742397,0.022723751,-0.06963562,-0.09361666,-0.033804383,0.016440062,0.021460965,-0.026303498,0.011179218,-0.033486567,-0.09915548,0.023840068,-0.03958185,0.010257296,0.012304346,-0.010674575,0.049316503,-0.04672168,0.028802698,0.04995023,-0.064715646,-0.056691624,0.016590625,-0.07141398,-0.011113154,-0.021291377,-0.028647095,-0.030534094,-0.09453436,0.0012367811,0.0019945053,0.20613182,0.0069127004 +1.2.1.2,"The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.",384,1.0,-0.03779112,-0.065495335,-0.22085556,0.030189915,0.07619404,0.020059284,-0.06617651,0.040004127,0.0022180153,-0.0334492,0.032953035,-0.08229075,-0.09260828,-0.017777896,0.024374157,-0.009561096,-0.04439922,-0.034616705,0.01611049,-0.041784115,0.064647004,0.009218981,0.008278098,0.014177677,-0.047576774,0.06935556,0.036328312,0.030608356,-0.08700678,-0.09883833,0.028540203,-0.03292176,0.14042737,-0.051512264,0.10970327,0.11266496,-0.031633146,-0.094229266,0.035788074,0.017076543,0.023884162,0.03712459,0.051003195,-0.0524501,-0.032281682,0.0050425413,0.020399256,0.027159838,0.012639372,-0.027758673,-0.022997564,-0.0909275,-0.031413693,0.05733271,0.003089498,0.05112927,-0.009031657,-0.015357257,-0.043731734,-0.03507985,0.019707646,-0.0009660063,0.023965197,0.011461443,-0.036473945,-0.0238799,0.03606056,-0.052338902,-0.008518713,-0.10723291,-0.10333293,-0.0081934845,-0.029740704,0.02020023,-0.07354525,0.0667037,0.018279698,-0.056379218,0.049816336,-0.015130239,0.03548447,0.010899242,0.07036703,0.0519997,-0.00409496,-0.003968441,-0.010112692,-0.03906914,-0.04013407,-0.00048803023,0.027718183,0.014399847,0.024806103,-0.051130064,-0.048391987,0.06512665,0.022692956,0.053260516,0.019376311,-0.06173612,0.009515347,0.059038687,0.017852949,-0.09447122,-0.015880248,0.0039547393,0.019076562,0.1246376,0.088950574,0.04055318,-0.014916377,0.006651361,0.056825966,-0.0306481,0.014776955,0.06682216,0.04797977,-0.05975435,-0.07023535,0.00088440167,0.029765239,-0.061015718,0.06521014,-0.031027772,0.028256485,-0.0148986885,-0.10859502,4.625022e-33,0.07398541,-0.01642217,0.01902126,-0.025940308,-0.02386685,-0.009091511,-0.0778747,0.0029559154,0.040667996,-0.022023547,-0.07724104,0.013196481,0.0821878,-0.029993474,-0.027351191,-0.027710881,-0.0071614515,-0.004760575,-0.010246754,0.03766152,-0.012904691,0.05752202,-0.005845289,-0.06389663,0.04823292,0.08092858,0.007599286,-0.031957865,0.021920662,0.0050030216,0.0081029795,-0.1296235,-0.12678085,0.08058209,0.086919546,0.053093307,-0.049772203,-0.022952124,-0.036752116,0.023067707,-0.033797037,0.034395333,0.016277947,-0.07311059,0.07046053,-0.051152993,-0.036183085,0.109229654,0.06663482,0.035864208,0.008840568,0.022972772,0.11366932,-0.043504603,-0.061818052,0.040769137,0.031594086,0.046703268,0.03905466,0.06678531,-0.010689291,0.09083151,-0.050654933,0.032465186,0.03227806,0.03528281,-0.0773047,-0.056329668,0.062421538,0.065268,-0.011584728,0.01030086,0.07221089,0.01592723,-0.01636373,-0.048305612,0.04672988,-0.057905555,-0.019941349,-0.0016154546,0.027417598,-0.01855798,0.011182967,-0.037856665,-0.041152343,0.027553985,-0.045065068,0.015089829,-0.042629566,0.0035023352,0.038765993,-0.06415372,-0.047684066,0.0014940387,-0.014167784,-3.5741725e-33,0.06177942,-0.03853294,-0.038706563,-0.08614527,-0.004829762,0.084608,0.05793161,0.009353517,-0.036958843,-0.013353493,0.10559427,0.0027785224,0.0072923107,-0.0593503,0.07270864,0.0745377,-0.01555689,0.056587804,0.00044717867,-0.04548595,0.044954706,0.033922367,0.018048042,0.0044270926,0.019578947,0.015089744,-0.069851905,0.047575675,0.0668025,0.01690053,-0.033989016,0.002399931,-0.03355437,-0.04119413,-0.046044663,-0.015263588,-0.072869845,0.027668186,0.011320631,-0.011220524,0.015302728,-0.016140485,-0.013456447,0.110998,0.082472555,0.06614699,-0.116895035,-0.004442926,-0.018622616,0.031042455,-0.02691466,-0.06788205,-0.030589832,0.013553262,0.05519493,0.04177824,0.0010040774,0.042188,-0.08865674,0.0025046738,-0.024110468,-0.03686433,0.049283862,0.063080184,0.0057704854,0.059829656,0.003489313,0.047690406,-0.009705129,0.029858893,0.09579677,0.024598032,-0.0448166,0.0057444265,-0.042128444,1.1953066e-05,-0.018249385,0.031718444,-0.0031714968,0.020240173,0.0475154,0.04475628,0.0027515693,-0.08790044,0.075498134,-0.039381064,-0.0157307,0.036169432,-0.020918725,0.03577665,-0.0008057127,-0.026065595,-0.03089827,0.009024226,0.02242619,-3.6898005e-08,-0.031316843,-0.0539326,0.13186611,-0.010700039,0.025980059,0.059200637,0.061623253,-0.035051767,0.014049043,0.0016023307,0.015853368,0.04691713,-0.013118364,-0.051496115,0.033368517,0.087122455,-0.048856143,0.05963724,-0.030417595,0.057972778,0.0098495595,-0.022210833,-0.13589041,0.068104826,0.022545138,-0.048285928,-0.039568815,-0.009186594,0.015485121,0.019211128,-0.009648814,0.058972485,0.049100436,-0.04460068,-0.12136294,-0.04565801,0.012669051,0.03124483,-0.15845828,0.010480862,-0.042265184,-0.028138418,-0.057498775,-0.013172305,0.028888185,-0.021327613,-0.020184638,0.017568626,0.031483848,-0.036177497,-0.01356367,-0.032044884,0.0036861324,-0.035637338,-0.11263638,0.05051378,0.012014568,-0.06785715,-0.045504432,0.019031826,0.04176632,-0.010906089,0.14444467,0.03847976 +1.2.1.3,"Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.",384,1.0,-0.08048627,-0.055846926,-0.0012429944,0.015933814,0.00043365997,-0.06392345,-0.07288853,0.09907414,0.008233111,-0.017293965,-0.036483508,0.023243966,-0.09878721,-0.0010157049,-0.04542475,-0.005624639,-0.009923315,0.044529334,-0.09775833,-0.018553978,0.048106804,0.01182752,0.008035776,-0.013514384,0.10174722,0.06472525,0.0266068,-0.014597755,0.015608137,-0.04041356,-0.038054887,0.010874651,0.043535095,-0.0068486854,0.019945476,0.03509341,-0.08557568,0.02692692,0.056279358,-0.048753444,0.01706001,0.004398122,0.043648686,0.041145887,-0.039336573,-0.014841833,-0.04825043,0.03235947,-0.06538903,0.050769653,0.09258268,-0.057881996,-0.08804556,0.017622568,0.009072081,0.0164087,0.009522502,0.053814344,0.045745376,0.020593606,0.02175536,0.05836359,-0.0074282223,-0.016837355,0.00045467605,-0.02638205,0.0635288,-0.08089292,0.010102724,-0.042259865,0.036233798,-0.011417353,-0.03799343,-0.007215294,-0.005825196,0.042742975,-0.024273293,-0.09517707,0.038496252,-0.051813312,0.12085532,0.1302776,0.12988822,0.060715247,0.024421433,0.04119879,-0.08246499,-0.052126236,-0.024475345,-0.039192557,-0.006871732,-0.06461737,-0.06740993,-0.031105146,-0.013923565,0.06402846,0.035651464,0.04635071,-0.005193438,-0.045048237,0.021047017,0.024121499,-0.113177046,-0.046240695,-0.08686561,0.03432474,-0.0019943928,0.019483726,0.0014127728,-0.047461733,-0.0039855773,0.07913451,0.022459656,-0.019118467,-0.092840284,-0.003149069,0.045232482,0.015510836,-0.07892919,0.014924089,-0.015062871,-0.056978155,0.046065938,0.017105073,-0.076731674,-0.02052015,0.06468547,1.686061e-33,0.07220462,-0.029760662,0.011484642,0.033811416,-0.0068235053,-0.023089767,-0.099967144,-0.065784626,0.045019194,0.054809242,-0.08864644,-0.005683315,-0.018688299,0.04177105,-0.0456292,0.11888192,-0.027293801,-0.02132887,0.073131226,-0.03913227,0.056484383,0.061970476,-0.046746757,0.028101629,-0.023625918,0.017403271,-0.00844158,0.059181884,0.011289222,-0.028403465,-0.025003213,-0.07694807,-0.05237256,0.04801633,-0.042709854,0.033450093,-0.12981704,-0.054778937,-0.009828015,0.029270263,0.012545125,0.011337613,-0.027218482,-0.038657784,0.030356044,0.051200945,-0.004445147,0.047456693,-0.017729418,0.0922007,0.028417503,0.03745326,0.04552329,-0.005299168,-0.04294836,0.028781584,0.03545567,-0.08248873,0.11920628,0.102232605,0.007347702,0.10600313,-0.01542479,-0.0146592595,-0.02278053,0.03835976,-0.12285471,0.035985682,-0.046245776,0.0175735,-0.012118895,-0.069532864,-0.0016705344,-0.025060099,-0.019620659,-0.037317097,0.0005824362,0.040523835,0.018317398,-0.07836442,-0.012346053,0.016296834,-0.010605489,-0.02365155,-0.11103414,0.020203184,-0.090816595,-0.061734755,-0.0074493643,0.0799356,-0.070086494,-0.03766593,-0.02817144,-0.006060665,0.025085762,-3.317919e-33,-0.01741095,-0.020280194,-0.0018403037,-0.031097148,0.008920146,0.01043614,-0.02268611,-0.011440876,0.047706403,-0.017035907,0.041995775,0.06667503,-0.11770258,0.006100522,-0.04377584,0.050931018,-0.061689433,0.10165216,-0.029768439,-0.027962916,-4.5641642e-05,0.043260783,-0.03702375,0.054785464,0.10079193,-0.010036097,-0.019865226,-0.039923467,0.08983103,0.05918778,0.008340889,0.009434962,0.00454427,0.04734785,-0.009581405,0.012867958,-0.005480707,-0.004368751,-0.039273467,-0.01792293,-0.06866414,0.076364964,0.055399768,0.09799299,0.077122554,0.055152103,-0.10662362,-0.07578107,0.025986206,-0.0053166286,0.06420687,0.019336745,-0.026091652,0.01724681,0.08090194,0.112850346,0.072569475,0.016532877,-0.021311436,-0.030174969,-0.039457083,-0.08436861,0.009948917,-0.06746181,0.051021382,0.058406916,-0.0018469254,0.07739313,-0.0052627944,0.04820585,0.09016606,-0.018264877,-0.014840327,0.010727201,-0.07778786,-0.11094331,0.043953534,-0.020016396,0.033181753,0.008433906,-0.0121014025,-0.005715492,0.015356647,0.012583081,-0.013568205,-0.05666338,-0.026823126,0.13456489,0.05203315,0.05045856,-0.06292662,0.0047729337,-0.021798689,0.024232266,0.07706121,-2.6668506e-08,0.011081618,-0.016893554,0.04127832,0.036592357,-0.008846408,-0.032707904,0.058521055,0.059862114,-0.019412054,-0.026343005,-0.028560814,0.1204238,-0.039786987,-0.032568716,0.04554672,0.03210331,-0.050027534,-0.0064874743,-0.026052404,0.05451182,-0.061824504,-0.008321173,-0.008549278,-0.03450988,-0.046778742,-0.11503065,0.08466393,0.026336601,-0.0040029963,0.043836284,0.0005321369,0.015828336,-0.026110591,-0.09936876,-0.0071838717,-0.014215371,-0.026035687,-0.0324172,-0.019792283,-0.03624351,-0.09773354,-0.027343672,0.045945954,0.057204243,0.034954112,-0.026403878,-0.03955755,0.038836636,-0.027220687,0.08536897,-0.008407358,-0.038443577,-0.040448472,-0.04145466,-0.091713354,0.04341611,-0.014593021,0.023158437,0.012037582,-0.107696205,-0.0036617531,0.0013504678,0.12662156,-0.026334092 +1.2.1.8,"In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria. In contrast, different enzymes are involved in the first reaction. In plants, this reaction is catalysed by EC 1.14.15.7 (choline monooxygenase), whereas in animals and many bacteria it is catalysed by either membrane-bound EC 1.1.99.1 (choline dehydrogenase) or soluble EC 1.1.3.17 (choline oxidase) [5]. In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 (glycine/sarcosine N-methyltransferase) and EC 2.1.1.157 (sarcosine/dimethylglycine N-methyltransferase).",384,1.0,-0.10138329,-0.116895065,-0.08396053,0.033059467,0.06477016,0.057092905,-0.06673436,0.05155289,0.04352288,0.009169777,0.0034461878,0.02386685,-0.019938227,-0.001734231,-0.050000083,0.049536124,-0.059289444,0.008320085,0.02738278,-0.0034013146,0.01629433,0.022456558,-0.036442295,-0.027474163,0.045108266,0.04037797,0.031178294,0.0110481465,-0.032647505,-0.014118671,0.0012214171,-0.093920745,0.12802728,-0.06017652,-0.037929818,-0.0057089725,-0.008491535,-0.1008186,0.0676248,0.032751784,-0.044492494,0.07096961,-0.06928809,-0.019459235,0.0645886,-0.06865766,0.04495414,-0.0237217,0.026355261,-0.04759465,0.0005475098,-0.050408904,-0.045525998,0.0021568167,0.007122507,-0.0102393655,-0.04576186,-0.03946069,0.035325143,0.028001603,-0.015330572,0.016547676,0.013771833,-0.055691656,0.026452953,-0.02500999,-0.04136166,-0.10530585,0.060069695,-0.06776887,-0.06816192,-0.05928459,0.0033775677,0.03650329,-0.035711072,0.0158479,-0.019471163,0.017316062,-0.014409905,-0.009865559,-0.007054791,-0.050073147,-0.026758969,0.04892385,0.03885157,0.032797325,-0.016419286,0.07776856,0.044862527,0.063760966,0.024768915,0.026874963,-0.022056669,0.013845328,-0.020767733,-0.032085057,0.07617361,0.054732062,0.03566176,-0.026815983,-0.046695087,0.04405628,-0.06420236,-0.048610292,0.037925385,0.039555375,0.07536388,0.076095775,-0.041492242,0.040666755,-0.018153192,-0.0045793173,0.033167653,0.058302987,-0.010420732,0.074640684,-0.0048347265,-0.0226922,-0.029920498,0.036198713,0.045745227,-0.036528323,0.03304049,0.07059109,-0.03328676,0.08653651,-0.03395069,3.875327e-33,0.060187865,0.04042272,0.01865752,-0.03168858,0.02387447,-0.0110421805,-0.10531227,-0.0028016479,0.01518262,-0.059435695,-0.037637364,-0.037319247,0.018580217,0.022713533,0.06883914,0.03481915,-0.035234146,-0.07380361,0.09972698,0.033583976,-0.042839903,-0.031133432,-0.017961916,0.03712027,0.09527697,-0.040197715,0.014279498,0.0032414584,0.028544873,-0.0043275654,0.0055850754,-0.16799936,-0.019267969,0.010795629,0.002113535,0.007519998,-0.06731158,-0.051452342,-0.029853167,0.033634946,0.0672519,-0.0031994404,0.017399719,0.014564466,0.07815786,-0.021540249,-0.06011265,0.13594607,0.013049675,0.045448188,0.01703207,0.015354385,0.070381865,-0.016836125,-0.0037483033,0.062187314,-0.027818851,0.012943505,0.047342993,0.12771879,-0.022984687,0.011142026,0.018998245,-0.018954033,0.024193702,0.050161995,-0.10219327,-0.05304079,-0.013860727,-0.0056203217,-0.05268599,-0.02178156,0.063285224,0.026843723,-0.048699662,0.0005503798,-0.024658414,0.071500026,0.030561715,-0.099326134,0.016899986,0.09037012,-0.0028634185,0.004704915,-0.017764548,-0.005111658,0.0029348356,-0.027600873,-0.022060925,0.016491704,0.0450892,-0.041608334,-0.06730192,-0.0013343672,-0.034124877,-3.612162e-33,0.09147239,-0.10112236,0.026767856,-0.09803315,-0.08823966,0.06872347,-0.062364526,-0.10759288,0.06577938,-0.013729211,-0.012562886,0.04274234,0.067193694,-0.0650162,-0.0004365648,-0.013181265,0.013601979,0.058176495,-0.036111902,-0.07917116,0.029979428,0.0822556,0.0445508,-0.005215011,0.02014578,-0.020913268,0.0030907618,0.07567753,0.0607124,0.09297071,0.014187629,0.058158115,-0.0068234676,-0.077337325,-0.040992398,0.06549587,-0.037191603,-0.004566176,0.073646806,0.07491066,-0.017711896,-0.006777373,-0.035702784,-0.018547213,0.0574652,0.12787142,0.026728563,-0.024774434,-0.012135961,-0.07024167,0.073124684,-0.06277603,-0.02268313,0.019174041,0.07743007,0.043217383,0.0028380207,0.031994008,0.040956687,-0.10832269,0.051398676,-0.014222859,0.079348534,-0.04010501,-0.066707365,0.02408234,-0.015683327,0.04171156,0.053665485,-0.021168444,-0.021404888,-0.0033795484,0.011842366,0.06874058,-0.010997333,0.022621226,-0.030254006,-0.048854727,-0.047684006,0.017965563,-0.029504752,0.06435548,-0.036348194,-0.032264154,-0.024551034,0.0066178646,0.025490142,0.15289786,0.0084422855,0.02444336,-0.037527975,-0.004267934,-0.08522585,0.05908644,0.086476825,-4.3929784e-08,0.03383836,-0.03081998,0.07105744,-0.0052438504,-0.019094445,0.033628207,0.06565115,-0.038473137,0.039895006,-0.07859337,-0.04653977,0.07069555,-0.01619223,-0.013145098,-0.047378857,0.036614023,-0.034941368,-0.0040984186,-0.016718062,0.0029824427,-0.02163373,0.031524,-0.061836004,0.05430574,0.015052696,-0.111577645,-0.014097816,-0.010947404,-0.05767286,0.0064756167,0.0138957305,0.023564862,0.002519271,-0.10679802,-0.052259542,-0.06058032,0.026259432,-0.0122723235,0.08471574,0.037125416,0.0151796285,-0.04567434,-0.094340526,0.006614814,0.034788154,0.06477891,-0.012898848,0.07724544,-0.044591192,-0.023723673,0.054914407,-0.044243433,-0.01294594,-0.09586925,-0.11833739,0.054383267,-0.04310174,-0.11266998,-3.345926e-05,-0.047352787,-0.06704817,-0.017697804,0.16937222,-0.032383233 +1.2.1.10,"Also acts, more slowly, on glycolaldehyde, propanal and butanal. In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87, propanal dehydrogenase (propanoylating). Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. NADP+ can replace NAD+ but the rate of reaction is much slower [3].",384,1.0,-0.04417956,-0.0029868728,-0.05007806,-0.02508648,0.029970657,0.0073271818,-0.13164881,0.0045408923,0.03276054,0.000438799,-0.012696341,-0.033987354,-0.07078091,0.017320797,-0.025654105,0.07205395,-0.020530878,0.013444394,0.02370977,0.004938786,0.061484143,-0.022101961,-0.024516251,0.04426041,0.05976793,0.067444645,0.012378624,0.034574237,-0.030221405,-0.049388524,-0.013701425,-0.051920526,0.049387645,-0.041483764,0.013169279,0.10147643,-0.05428972,-0.085468866,0.047854163,0.053321224,0.046626482,-0.008482214,-0.057316314,-0.017926015,0.021511015,-0.022190547,0.047997784,0.05145477,0.04075463,-0.034295376,-0.091416985,-0.031240633,-0.028429791,-0.012741275,0.030512221,-0.012941073,0.007197296,-0.0014428073,-0.009867523,-0.0024535332,0.06281397,-0.03775234,-0.024566699,0.032722898,-0.0423247,-0.042655263,0.079333976,-0.07313147,0.04478699,-0.029533314,-0.06047928,-0.03859614,0.008862719,-0.0006315978,0.0397018,0.03709746,-0.028144496,-0.086199805,0.06055905,-0.053921,0.034674738,-0.05097235,-0.003941801,0.016639136,0.005075238,-0.045142543,0.041902374,-0.031854473,0.005902532,0.002636096,0.013412708,-0.009113166,0.016508162,0.02501661,-0.04996426,0.032744475,0.04850332,0.04527356,0.07212622,-0.08228653,-0.042820822,0.102885306,-0.04353036,-0.061986394,-0.015281128,0.01802456,0.028810605,0.1798691,-0.0035719639,0.052084003,0.0054190923,-0.036333617,0.045077503,0.010074015,-0.013435567,0.1014759,0.0068592583,-0.045571797,-0.06436412,-0.012042826,0.015465698,-0.033363592,0.018290779,0.038216542,-0.033417225,0.043978784,-0.096032545,2.3818715e-33,0.10301991,0.020237498,-0.05974246,-0.025877887,0.03236071,-0.0081380615,-0.079835735,0.027691709,-0.043936852,-0.076850325,-0.0070753223,-0.012841715,0.005519539,0.023990382,-0.033387654,-0.024331093,-0.021807859,0.015333107,0.029352548,0.037162907,0.04268444,0.009429823,-0.032272544,0.030144947,0.014400272,0.043149196,0.019732172,0.06981545,-0.049567986,-0.017123995,0.035019323,-0.1476394,-0.17497252,-0.014007346,0.032422177,-0.029445983,-0.03957842,-0.047887318,-0.003034254,0.0660609,-0.094663255,0.07963269,0.012842738,-0.057328597,0.05138363,-0.0416723,-0.012206622,0.14515013,0.038008183,0.08897536,-0.007915936,-0.05967396,0.10715321,-0.0056168875,-0.06375396,0.026718438,0.0024670146,0.008078801,-0.0024191835,0.039924785,0.030940486,0.1365449,0.0051819896,0.07763562,0.0012922449,0.0183767,-0.038645945,-0.027459092,0.050415866,0.043897547,-0.059519127,0.0662277,0.06255683,-0.050941627,0.03917226,-0.07139185,-0.040929727,-0.015856653,-0.030521361,0.013046694,-0.011364411,0.017444147,0.04794813,0.025149066,-0.031961996,0.033927407,0.0018932468,-0.00078746927,-0.0024510445,0.08930485,0.0009599072,-0.056929916,-0.0062445453,-0.016286483,-0.002608417,-2.9263116e-33,0.1106926,-0.11878887,0.07995985,-0.014568493,-0.10995905,0.0925073,-0.010902346,-0.027675692,0.008585564,-0.054558214,0.10042855,0.063206494,0.08768447,-0.07625415,-0.0034091685,-0.014384083,-0.050486702,0.033954553,-0.058732897,-0.03756558,0.031902492,0.095093824,0.013819491,-0.021745749,0.0151469745,-0.03911141,0.013534944,-0.005635854,0.042450763,0.022033919,-0.015137186,0.03070855,-0.098078296,-0.02155866,0.044410005,0.10180261,-0.08979562,0.03221679,0.06689905,0.021502474,0.018071175,0.015047684,-0.04784779,0.011979508,0.06392444,0.04501581,-0.063444875,-0.007597082,0.051324677,0.008804397,0.020996872,0.010135654,-0.07665371,0.012408552,0.018803265,-0.004218101,0.008374121,-0.007876558,-0.025106687,-0.015171363,-0.030683694,-0.08832588,0.0886922,0.015819104,-0.010348721,0.04865719,-0.0550048,0.02934287,0.11297137,0.0061232443,0.12286844,-0.027423898,-0.017545143,0.041120898,-0.0009941034,0.008239048,-0.06832171,0.0071191504,-0.048988506,0.03787348,0.06462084,0.018893944,0.026130525,-0.07854501,0.016152302,-0.032745037,0.019073866,0.09363246,-0.07368957,0.034703523,0.022014065,-0.05214761,-0.023111822,0.012643541,-0.0096519105,-4.2958813e-08,0.0034930995,0.0013827223,0.10833777,-0.004498549,0.00089162687,0.002896856,-0.0213158,-0.03228498,0.04848979,-0.024184963,0.014807472,0.075520344,0.02956531,0.0039237672,0.03626043,-0.048472475,-0.009629043,-0.014806717,-0.039656278,-0.011340328,-0.09934598,-0.08296415,-0.14229465,0.024522578,0.06955834,-0.062136076,-0.0006879904,-0.029789722,0.041483972,-0.031401657,0.022234568,0.019119496,0.011852761,-0.012187025,-0.010674317,-0.04769503,-0.049298495,0.048131187,-0.048425995,0.070975386,-0.0024180876,-0.13779707,-0.07972429,0.04487989,0.0065936376,0.01900159,0.014608017,-0.014357038,-0.059357457,0.02084818,0.111612014,-0.046119995,0.0015448466,-0.05672313,-0.098768495,0.04302636,0.015346331,-0.049153555,-0.008847698,-0.057383396,0.044780795,-0.0021633997,0.1195988,-0.08411642 +1.2.1.12,Also acts very slowly on D-glyceraldehyde and some other aldehydes; thiols can replace phosphate.,384,1.0,-0.033999253,-0.04734712,0.046019755,-0.040318955,0.0067867097,-0.077948414,-0.03974426,-0.007385554,0.036901083,0.050662026,0.0014919192,0.060405277,-0.07906774,0.020760795,-0.03873418,-0.027094152,0.031997085,0.046871446,-0.048480187,-0.011086709,0.04806009,0.054596193,-0.0096231885,-0.052396897,0.10413008,0.013075205,-0.00424842,0.009164699,0.018195782,-0.08479846,-0.08189848,-0.0279048,-0.016633045,-0.038840283,0.010292248,0.111312345,-0.06501344,0.058688316,0.0072356295,-0.06032054,0.07622826,-0.06271958,-0.0319762,0.011695314,-0.05293211,-0.0025357055,-0.023945086,0.06782117,-0.013811782,0.049079526,-0.043191954,-0.084548436,-0.030319097,0.0043416442,-0.039310325,-0.014915204,-0.032258194,0.14032838,-0.012482828,-0.031826694,-0.016466008,0.008303221,0.02792386,0.035296597,0.048700873,-0.052581407,0.09792643,-0.021093765,-0.011807082,-0.011698591,0.03692119,0.029951442,0.030520702,0.0045039537,-0.0012977128,0.048505146,-0.08320747,-0.067186765,0.049482238,-0.036998633,0.094654396,0.086223856,0.0642722,0.07723033,0.03863396,-0.012227079,-0.031149786,-0.015928676,-0.11773614,-0.062332086,0.07077433,0.038035896,-0.0030502866,0.017115662,-0.038852677,0.030555135,0.075392485,0.02163359,-0.007617663,-0.04296957,-0.06616173,0.06487084,-0.095608264,-0.04675424,-0.0778199,0.03229412,-0.06318524,0.029582748,-0.018294308,-0.01948671,0.027615935,0.051805113,0.005789285,0.03218232,-0.10041055,0.026574384,0.008878084,-0.017118286,-0.068480976,-0.02381107,-0.06683356,-0.05949384,0.027174506,0.028342951,-0.037915193,0.06138445,0.010344797,1.9295255e-33,0.09646635,0.026484344,-0.0072115166,-0.054444782,0.011411558,-0.027188098,-0.08544156,0.026603565,-0.05172326,-0.000316894,0.014072711,-0.09639274,0.022462886,-0.028345922,-0.017110659,-0.0075523583,-0.037920594,0.0025877112,0.08082596,-0.048060257,0.06864899,0.061505105,-0.076733395,0.03279724,-0.0101485355,0.023659846,-0.015361921,0.05108975,0.036676,-0.0030714036,0.045554645,-0.0884385,-0.053279046,-0.015172553,-0.043262534,-0.0058728955,-0.05968809,-0.04307962,0.008167111,-0.03714148,0.00092294434,0.011105237,0.007122317,-0.070711285,-0.008511896,-0.03603002,-0.0313821,0.028729793,-0.029792005,0.07203505,0.08355653,-0.05017798,0.036530305,-0.016835319,-0.08673552,0.011607398,0.012887204,-0.058640663,0.013099526,0.076935306,0.03812684,0.020636877,0.025550827,0.021737406,0.005572168,-0.014314024,-0.10996484,-0.018874556,-0.04692343,0.073434405,-0.008959788,-0.024627762,0.10155228,-0.030207852,-0.049045436,-0.034331985,0.026682831,0.006993699,-0.04198781,-0.02567224,0.06681675,-0.024943195,-0.008923986,-0.0506813,0.000862219,-0.021690633,-0.021967089,-0.09533552,0.015402022,0.036623977,0.05841995,-0.07130081,-0.11748137,-0.059021577,-0.034727298,-3.2020183e-33,0.11271912,-0.05488176,0.08970385,0.041896768,-0.021327268,0.043552503,-0.02510472,0.09662187,0.035201866,-0.04531329,0.05151665,0.021520065,-0.04036767,-0.008909289,-0.055894967,0.053505544,0.0432982,0.002614552,0.014738271,-0.010731603,-0.0019217506,0.09718562,0.021284422,0.05041763,0.073483974,0.0039450023,-0.010698643,0.0036185835,0.03273487,0.07867803,0.054996412,0.03944763,-0.1053186,-0.06521608,-0.03754673,0.05308989,-0.06169116,-0.029800478,-0.016143998,0.029909858,0.014101454,-0.030881386,0.11609194,0.030322997,0.04679475,0.08236774,-0.043654773,-0.027532334,-0.016921803,-0.01489949,0.09385306,0.05325748,-0.03262835,0.11152475,0.06959996,0.07820935,0.008000977,-0.035962157,-0.054781415,-0.035213407,-0.020055912,-0.07322199,0.0019003114,-0.080348805,0.032847214,0.05705863,-0.05720896,0.05594625,0.076797955,0.014711245,0.06589544,-0.009442518,-0.03796264,0.040173586,-0.053484753,-0.04030481,-0.03337314,0.0013284063,-0.005604355,0.022823324,-0.011915653,0.06561081,-0.030671436,-0.046880357,0.010139372,-0.022762824,-0.025499377,0.14484705,-0.06177299,0.05595853,-0.04094994,-0.023611365,0.026486285,0.03699628,0.08334495,-2.8092334e-08,0.034625866,-0.06338332,0.054897025,-0.018994557,-0.024881294,-0.0524686,0.062420744,0.133953,0.0106763365,-0.06313029,-0.04124789,0.09489358,0.042912394,-0.025300898,0.061262902,0.030360233,-0.04847927,-0.041917205,-0.06675167,-0.06943258,-0.10531981,-0.0047264886,-0.051957402,0.054715637,-0.042567614,0.027144883,0.080947205,-0.06308736,-0.012070569,-0.011073823,0.040585004,0.015765125,-0.011559606,-0.061346404,-0.019243134,0.027646665,-0.03447124,-0.011433734,0.0062856176,0.013745109,-0.065246485,-0.0506143,-0.058399245,0.0766093,-0.044657405,-0.033674385,0.014941395,0.06137834,-0.061312847,0.0011666524,0.051017582,0.00274848,-0.103067376,-0.068089485,-0.06735355,0.0017911698,0.045115724,-0.0074928757,0.027934624,-0.057204917,0.034346215,-0.013254738,0.15061998,-0.018280895 +1.2.1.19,"The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].",384,1.0,-0.035718538,-0.12992103,-0.107152574,-0.039152224,0.048384514,0.09861719,-0.03552904,-0.004763637,0.033021886,0.017989406,0.070539765,-0.027643574,-0.1008615,-0.0024653138,-0.060426306,0.036936093,-0.11311182,-0.07450595,0.06556688,-0.049189188,-0.013270636,0.0043594735,-0.031250242,-0.04140895,0.047170058,-0.044959508,-0.020938199,-0.012026284,-0.0362366,-0.09048419,0.0126133915,-0.034343045,-0.03440941,0.07045915,0.018608674,0.0879136,-0.07201952,-0.040346846,0.04008753,0.03632712,0.05772237,-0.0028179088,-0.04639592,0.007882045,-0.07409381,0.02485971,0.072934665,0.012576859,0.0099851815,0.0015032074,-0.01613935,-0.048155595,0.014096574,-0.005722275,0.025216391,-0.020665865,0.013757935,0.040711675,-0.008208179,0.059405345,0.04221854,-0.021305265,-0.012388817,-0.037533093,-0.019338433,-0.026640927,0.012966462,-0.04971409,0.06803374,-0.0052382015,-0.07023654,-0.06036809,-0.07435102,0.018318636,-0.09528551,0.0801008,-0.05433075,0.0065679266,0.031360395,-0.035281587,0.0021639124,0.06274114,0.05697676,0.018093253,0.040270135,-0.051111024,0.017603487,0.037342723,0.047617644,0.02942471,0.056208458,0.028019644,-0.013095853,0.025536383,-0.05300578,0.07435926,0.080393866,-0.034781422,-0.017169097,-0.06502339,0.018410023,0.010438278,-0.01698681,0.00792511,-0.049242932,0.025114233,-0.007205843,0.0138963,-0.037466366,-0.021124735,-0.07159795,0.045398645,0.002340068,0.0382008,-0.023663793,0.05702773,0.09279034,-0.062141955,-0.09177027,0.032258227,-0.055910524,0.07259165,0.09826842,0.091854915,-0.055962913,0.031333186,-0.10044259,4.25734e-33,0.07717278,-0.028454594,-0.023246465,-0.013633613,0.11365707,-0.012082724,-0.098898485,0.07536705,-0.06094819,0.048096936,-0.053770464,-0.111436695,0.04772845,0.021768263,-0.05455346,0.04269165,-0.07213699,-0.0059187375,0.067266695,-0.022752618,-0.0676554,0.006236654,-0.08589617,0.012175586,-0.024974443,0.04010516,0.011610993,0.01807536,0.029985571,-0.017016046,-0.025931038,-0.102684036,-0.111725666,-0.016614966,0.027646514,-0.059644148,-0.012519,0.007148573,0.011603437,0.03482792,-0.0011337633,0.0070517636,0.071179725,-0.069162264,0.048223324,-0.022922216,-0.049277205,0.10026913,0.010727393,0.06476146,0.05579734,-0.025375219,0.10741795,0.011608213,-0.073034376,0.046521544,-0.059749078,0.003909168,0.0313686,0.022776596,0.04445706,0.04814453,-0.016174756,-0.013646566,0.017203648,0.041501146,-0.04965034,-0.09406144,0.047415834,0.10487284,-0.030496476,-0.06867703,0.045973074,-0.017975492,0.060811844,0.0071257427,-0.10791649,0.009482718,0.03696746,0.027455423,-0.069890976,0.039413888,0.025187943,-0.040861744,-0.048333522,-0.07996382,-0.018354561,-0.032983154,-0.004383208,0.045012355,0.016850507,0.016881648,-0.028798547,-0.0022789878,0.06544969,-4.1596792e-33,0.12520957,-0.042904068,0.008776171,-0.07921521,-0.06482251,0.054258645,0.037247844,-0.013256584,-0.017110921,0.030392561,0.09606363,0.05227719,0.0003045086,-0.0015809921,0.029875802,-0.012040239,-0.0496261,0.077322565,0.042151887,-0.03656171,-0.0024298762,0.04551001,-0.0282301,0.024846349,0.03317811,-0.0014163621,0.035021342,0.026876137,0.032395713,0.026069904,-0.049420845,-0.018878253,-0.022164298,-0.028884005,-0.04547093,-0.0022592957,-0.080246,0.016300846,0.001266076,0.03296446,0.021672312,0.03337288,-0.0075899926,0.054777525,0.018531,0.017986951,-0.061058782,-0.008839032,-0.077811524,-0.060133494,0.027262429,0.030054273,0.029111102,0.028745376,0.023940224,0.03302446,-0.006699678,-0.01651994,-0.019906567,0.004994188,0.01052361,-0.034977693,-0.034997366,-0.008091136,0.030986028,0.05037407,0.0049120346,0.092122816,0.0011520629,-0.01817635,0.10426944,0.0039946423,0.016404323,0.0993286,-0.010826111,0.009950423,0.05835463,-0.020271037,0.017642397,-0.0599759,0.018507121,0.026911965,-0.048700616,-0.07518244,-0.021306783,-0.07806317,0.03961892,0.11354599,0.077661425,0.068020225,-0.015313781,-0.03195942,-0.033101715,0.06320064,0.083189525,-4.3661462e-08,-0.042346306,0.013974228,0.051197316,-0.020074077,-0.006928989,0.021427223,0.025404576,0.04789676,0.01064067,-0.038512368,0.020803,0.05295396,-0.0037806884,0.10892627,0.06926922,0.02440364,-0.032281637,0.005839173,0.0023775452,0.065396376,-0.09380266,0.04554836,-0.1790342,-0.006867576,-0.009340443,-0.05336438,-0.016639184,0.06986878,-0.0031384774,0.009477939,0.06679451,0.08566456,-0.0026944142,-0.060103223,-0.082072616,0.010666359,-0.037616983,-0.062324364,0.010078415,-0.027739607,-0.050248686,-0.04009784,-0.0019987796,-0.044185665,-0.03185992,0.014698608,-0.038477298,-0.01755174,0.018435143,0.120260365,0.066132985,0.05455605,0.050477847,-0.054492384,-0.088796124,-0.018452387,-0.01929658,-0.12208921,-0.046349823,-0.0711303,0.0015665044,-0.033816487,0.13708842,-0.020533448 +1.2.1.20,"The enzyme, characterized from multiple Pseudomonas strains, participates in L-lysine degradation. Unlike earlier claims, it prefers NADP+ to NAD+.",384,0.99999994,-0.05768936,-0.07992226,-0.028228171,-0.0067321486,0.13353989,0.09241566,-0.124383315,0.09286293,0.006016792,-0.008688063,0.0020398276,0.022177648,-0.05435178,0.07963166,-0.04981426,0.09373524,-0.06729815,-0.04453123,0.0036671439,0.05646829,0.07552836,0.09546537,-0.06819085,0.04321129,0.09691069,-0.01389639,0.04640689,-0.01125264,-0.020358803,0.0066151465,-0.075728685,0.015214519,0.038872205,-0.1031894,0.044823658,0.0650232,-0.078429446,-0.025761638,0.10561721,0.010781588,0.0034436295,0.00097017514,-0.081788234,-0.05983413,-0.037255842,0.0019423253,-0.028225098,0.061757915,0.029080521,-0.00021337283,-0.027308157,0.0025817298,0.0034969675,0.06574023,-0.09317495,-0.028059652,-0.033034302,0.018631024,-0.045258805,-0.017864982,-0.02844477,0.021285236,0.0038606464,0.034706622,0.08752999,-0.07437385,0.063887514,-0.0027394523,0.028061029,-0.015065992,-0.13283315,-0.03607959,0.044311807,0.07058508,0.053999193,-0.02953238,-0.0227074,-0.046879504,0.04422007,-0.0159748,0.014404567,-0.008422161,-0.031596538,0.057868958,0.033348363,-0.07905749,0.00088176265,0.035260037,0.03328184,-0.048207875,-0.0043417164,-0.031401433,-0.05276496,0.018028496,-0.08538037,0.03284859,0.0148923965,0.013379469,0.0070264237,-0.06073244,0.01622525,0.06442881,0.0057200543,-0.0648833,-0.0014294556,-0.010327283,0.022151927,0.08433288,-0.00050613156,-0.056331307,0.067504205,0.013616609,0.034295935,-0.05365813,-0.0010448353,0.062224675,0.01932965,-0.026397694,-0.100452535,-0.009266721,0.01576204,-0.06718849,0.047672115,0.04599375,-0.016760126,0.04639832,-0.09426592,-1.061309e-33,0.08839083,-0.017470602,-0.05822073,-0.042524107,0.025577651,-0.013034566,-0.093642026,0.01380767,0.008782931,-0.057586394,-0.0012033,-0.063688144,0.021805974,-0.013718861,-0.017230803,0.06784255,-0.04806678,-0.037131846,0.027058344,0.050229426,0.012089203,0.052507024,-0.010698668,0.059348155,0.057443585,0.06677589,0.05449632,0.053628612,-0.09119655,0.009424499,0.017257323,-0.087100975,-0.13608515,-0.025713058,0.060434535,0.021516675,-0.01676593,-0.08927362,0.05021574,0.0111708855,-0.00839331,0.10128446,0.013477637,-0.015831055,0.07149606,-0.043488458,-0.031974584,0.12050391,-0.065801635,0.062314805,0.06732039,-0.101308696,0.0564166,-0.04599369,-0.037343837,-0.011189075,-0.038576517,-0.0015223769,0.010604494,0.06359695,0.098468706,0.04473514,-0.015408173,0.082922176,-0.05394103,-0.02460329,-0.05402824,-0.038364317,0.055698324,0.0008745562,-0.060153127,-0.0046466384,0.06682469,0.042531323,0.013414812,-0.08899506,-0.023416044,0.035251938,0.043679677,0.001440595,0.004641737,-0.06162125,-0.03994352,-0.00363574,-0.049611185,-0.0025373357,0.07167154,-0.0900154,-0.015522101,-0.027332556,0.06434332,-0.05876263,0.02541785,0.044409968,-0.023569377,-9.372832e-34,0.037754696,-0.04862782,0.0719109,-0.043172322,-0.040465835,0.027796617,0.007463393,-0.022494743,-0.0012492195,-0.07624581,0.05233786,0.010921563,-0.012077153,0.00046111425,0.06378298,0.04719234,-0.0011344354,-0.047948737,-0.04038164,-0.026833234,0.031073436,0.07235323,0.019707074,-0.01911622,0.07950471,-0.021652112,-0.09065643,0.084140465,0.06101331,0.03343176,0.015145981,0.029576419,-0.052450895,-0.074039005,0.014996925,0.05002158,-0.020005403,0.0059170783,0.045090616,-0.014055371,0.09498309,-0.00068503746,-0.038425002,0.018118765,-0.02415558,0.03915301,-0.068866424,-0.08032128,0.06430313,-0.10858679,0.018547434,0.0029503836,-0.030949382,0.0278395,-0.03189858,0.022430727,-0.04790372,0.07355851,-0.05057105,0.019814614,-0.054254673,-0.059268292,-0.024730776,0.056447003,0.00327427,0.007884855,0.028109115,0.026137756,0.011490971,-0.029890258,0.0894136,0.041074894,0.050401695,0.060405895,-0.09328649,-0.019568227,-0.10340498,-0.057423852,-0.022128029,0.017066648,0.0026991619,-0.02465078,-0.016083565,-0.048117194,-0.019445572,-0.064051434,-0.013559914,0.11232316,-0.032524157,-0.0035904532,0.060492143,-0.02090737,-0.044224124,-0.03128399,0.04962841,-2.7069937e-08,0.071687624,-0.0381195,0.045309823,-0.021907048,-0.014765508,0.028109923,-0.0026431226,0.017906828,0.02702376,0.022849243,-0.018343957,0.094618574,-0.043622322,-0.026555205,0.04246729,0.017221106,-0.09338954,0.047081206,-0.03801368,0.005932912,-0.06817259,-0.04692369,-0.06882924,0.03130133,0.013651202,-0.00528036,0.031690218,-0.035048753,0.057575714,-0.08389416,0.016412616,0.03618196,0.06644619,0.00086714013,-0.10166069,0.041431803,-0.0318877,-0.013335591,-0.017526232,0.080003634,-0.014926847,-0.01872954,-0.111339994,0.013336591,0.054850098,0.013338817,0.06244249,-0.035672277,-0.024819102,-0.04824163,0.08903473,-0.07197869,0.016494006,-0.014356012,-0.021032663,0.015324599,-0.04163399,0.017989043,0.0038834477,-0.05465228,-0.02681717,0.07029709,0.1295492,-0.035378747 +1.2.1.23,Not identical with EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+).,384,0.99999994,-0.08916092,0.013200965,-0.0059439396,-0.03886714,0.048809756,-0.041523185,-0.10558486,0.05595092,0.041090056,-0.06716575,0.050166044,-0.06542139,-0.073083155,-0.022249242,-0.043075018,-0.020038536,-0.013851172,-0.07139317,0.044032115,-0.013815414,-0.012381409,0.043739397,0.01107711,-0.009395379,0.09602827,0.05478785,-0.0036060417,0.08872649,-0.035220347,-0.085833065,0.053619884,-0.016659435,-0.0026575506,-0.047980018,-0.0011233455,0.019850228,-0.011264373,-0.04613985,0.01087366,0.053482905,0.035451666,0.035269454,-0.05594374,0.01380864,-0.037994634,-0.04554107,-0.029598335,0.06962886,-0.044988055,0.020805933,-0.00788679,-0.03288346,-0.008523625,-0.0023975587,0.049493268,-0.027585883,-0.03954026,0.014870562,-0.057620715,-0.022689627,-0.0075107366,-0.03206249,0.05073543,0.047189992,0.026806813,-0.03289642,0.08662932,-0.14903805,-0.004660501,-0.044513304,-0.107165396,-0.028343853,0.0336448,0.06696394,-0.0519304,0.084557086,-0.065663174,-0.028069006,0.05351795,-0.048036166,0.012249953,-0.00260325,-0.06611713,0.011325952,0.02952513,-0.027836232,0.07727444,-0.013750089,-0.02510418,-8.079225e-05,0.027993822,-0.011167295,0.010654335,0.07934715,-0.082067296,0.041738257,0.054412063,0.15959382,-0.043373875,-0.05699919,-0.033421442,0.13788174,-0.05406084,-0.032296836,0.0011014944,-0.005166715,-0.007985472,0.062625684,-0.028336326,-0.029409546,0.03169323,-0.06643424,0.03452385,0.02909765,0.012524388,0.061068848,-0.019917564,0.007520491,-0.019470984,-0.008607031,0.06299679,-0.07363664,0.038751207,0.04743638,-0.033730347,0.015821083,-0.0945579,4.029831e-34,0.061364535,-0.0063369,0.021631386,-0.0055327564,0.023178691,-0.00556158,-0.124002255,0.07983743,-0.04743463,-0.0044878563,-0.094852075,-0.03776441,0.068744354,-0.03524305,-0.053920154,-0.017868882,-0.053555593,-0.013003213,-0.012799185,0.014908868,0.041351616,0.08279927,-0.016176824,-0.0032975597,0.025118634,0.011943111,-0.047681164,-0.015303098,0.028800089,0.009132768,0.038778767,-0.1462182,-0.07008059,0.015163195,-0.018174421,-0.016291996,-0.005310189,-0.069166645,-0.011200325,0.03303168,-0.049967967,0.07080375,0.0464926,-0.09768127,0.03821251,-0.0836906,-0.024281317,0.053864226,0.04475568,0.02530058,-0.035774935,0.007619213,0.09126456,-0.070211135,0.0018450968,-0.010268801,-0.03662593,0.06109566,0.0245927,0.11837013,0.03221562,0.11869315,-0.024419859,0.0033250435,-0.01594934,0.025784655,-0.058355708,-0.0638258,0.025317453,0.058654748,0.01830625,0.04334547,0.11376252,-0.020262599,0.04670984,-0.04345934,-0.01166437,0.042863045,-0.011244697,0.04269272,-0.07067627,0.011875803,0.0031126083,-0.057694856,-0.020132316,0.05438455,0.013603154,0.035395104,0.017532045,0.09965009,0.056755092,-0.008826275,-0.030790823,-0.08050399,0.044222113,-1.4753645e-33,0.004068032,-0.011468304,-0.00017733357,-0.067801304,-0.031566396,0.12788011,0.033950023,0.010755554,-0.0148332175,-0.021442318,0.14377509,0.05438376,-0.013211944,-0.07391607,0.08219718,-0.041633107,-0.06196301,0.035722747,0.008032051,0.046092767,0.046166092,0.10699768,0.0071969763,0.018927194,0.054036934,0.014884753,-0.02323726,0.027643796,0.063392706,-0.039079547,-0.041307237,0.055055402,-0.082722075,-0.00873241,-0.0032256835,0.037426267,-0.06926751,-0.02946672,0.010830398,0.045446858,-0.037449285,-0.010232595,-0.06733384,0.020292327,0.084115095,0.03999749,-0.06649618,-0.01465785,0.064428754,-0.05723398,-0.020411948,0.07145318,-0.08905106,0.021769896,0.051877275,0.025295496,-0.026396155,0.085852936,0.03102474,-0.0060911304,0.004671193,-0.024432,0.040643062,-0.017433342,-0.012568015,0.039187398,-0.023818115,0.022286352,0.024391843,-0.0062925965,0.03608254,-0.0481086,-0.028651053,-0.033212554,0.017737824,-0.07607453,-0.034130625,0.034948923,-0.028930776,-0.038431644,0.02134674,0.014475547,0.0052127405,-0.032562993,0.010912817,0.018783998,-0.008472143,0.05513548,-0.050611105,0.039139524,-0.012246826,0.03860974,-0.13212745,0.037663646,0.023161832,-2.4633783e-08,0.06900111,-0.03030183,0.07573431,-0.0064302683,0.06340791,0.013011422,-0.03169887,-0.011428963,0.016312366,0.021315917,0.037985012,0.097539775,0.048770417,0.008243108,0.018137928,-0.05042154,-0.06561156,0.007994716,0.008115494,0.019852431,-0.052093577,0.024590796,-0.10336785,0.00064151024,-0.011030597,-0.017377324,-0.02406019,-0.060587175,0.05074123,-0.06579465,0.04511054,0.019540396,0.074135855,-0.07363003,0.0030775848,-0.028603649,-0.06013155,0.06944874,-0.07393698,0.05885248,-0.017741691,-0.13627164,-0.0058758915,0.035687774,0.079685465,0.051776957,0.078196734,-0.06829401,-0.08606728,-0.04874454,0.057088923,-0.015267586,0.05257364,-0.05918875,-0.054441083,-0.01665684,-0.066371575,-0.10737744,-0.0011433117,-0.021515358,0.028367227,-0.060741168,0.11121333,0.023152964 +1.2.1.24,"This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.",384,1.0,-0.028958414,0.021470988,-0.04034627,-0.039716236,0.07617266,0.067034185,-0.063491076,0.050912164,0.015115791,-0.003957875,0.013502519,-0.0045279614,-0.040828183,0.013258283,-0.038959786,-0.0024217656,-0.026670353,-0.040733356,-0.0016384945,-0.06439211,0.022783127,0.03520426,-0.025526593,-0.024850933,0.10203431,0.07030763,0.031155571,0.005157775,-0.029420935,-0.063012235,0.019077364,-0.03968507,0.028910972,-0.029790446,-0.0061356556,0.078083135,-0.10793051,-0.04659121,0.02111534,-6.409666e-05,0.016452124,0.045004226,-0.077291444,-0.04960336,-0.03808827,-0.059183773,-0.006263538,0.032907706,0.010926273,-0.011546391,0.024242219,-0.00868497,0.027894959,-0.0035012662,0.0536799,-0.013702502,-0.041451484,-0.031523608,-0.059235234,-0.02528313,-0.0067597176,-0.030752983,-0.0075045787,0.008196777,0.07894965,-0.04258086,0.12252135,-0.07504347,0.010900829,-0.04279492,-0.15445273,-0.051765315,0.02940486,0.06469616,0.018750373,0.010816987,-0.052801788,-0.05401685,0.07657451,-0.050044935,0.08479906,0.009905869,-0.027011167,0.027351635,0.059174657,0.0097837085,0.08977951,-0.0138539905,0.0003501203,0.020019779,0.02778381,-0.022439243,-0.028378194,0.041119855,-0.12398728,0.04765325,-0.019156903,0.059586212,-0.012168994,-0.055458903,0.011592981,0.13500279,-0.020799946,-0.05023794,-0.012649106,0.016566217,0.00519911,0.10980694,-0.028150152,0.006105686,0.016248472,-0.050490532,0.010715588,-0.029844709,-0.015715878,0.11767348,0.035178114,-0.0112073645,-0.06161678,-0.03929783,0.036312904,-0.02559543,0.057327133,0.027535291,-0.03584044,0.05424406,-0.13530828,7.932972e-34,0.04913731,-0.042945623,-0.035453178,-0.04181659,0.05938981,-0.009361736,-0.11042735,0.112289324,-0.034115236,-0.058093924,-0.035512164,-0.060402468,0.05502348,-0.01644247,-0.006593302,-0.010454631,-0.046252333,-0.05111339,0.020692296,0.00856612,-0.013768898,0.059581794,-0.008335227,0.040647503,0.044784952,0.018357178,-0.0283972,0.073279135,-0.019713013,-0.0016665839,0.030804861,-0.07822898,-0.17983237,-0.032063633,0.04097288,-0.032609742,-0.017464321,-0.049720433,0.01173619,0.05648395,-0.07294671,0.05541307,0.023279596,-0.024387939,0.033095285,-0.08683389,0.0016593797,0.10110887,0.055005766,0.040553175,0.050969202,-0.07597299,0.10396705,-0.07117875,-0.03856045,0.06966124,-0.0021071418,-0.014682478,0.010150297,0.08968425,0.036070723,0.053235378,-0.06277387,0.012353571,-0.006361359,0.0102384435,-0.08404118,-0.09182099,0.055052444,0.022396918,-0.050405905,0.010306345,0.09113693,0.015704617,0.006486777,-0.03991688,-0.022474762,0.035722815,0.0064704157,0.0475317,-0.05882158,-0.019162087,0.002167585,-0.032555528,-0.009495359,0.010528524,0.014927695,-0.07002142,0.027351325,0.05351461,0.030565722,-0.027241377,-0.03856328,-0.025375603,0.040936258,-2.497955e-33,0.07227127,-0.03260129,-0.008593251,-0.032208286,-0.051654015,0.0851914,0.031235924,-0.0017892476,-0.041913293,-0.051501293,0.0941432,0.039300513,0.065482534,-0.03921579,0.10066133,-0.037524354,-0.08216609,0.040595975,-0.04507903,0.009079702,0.029018624,0.1288257,0.04013001,-0.026441678,0.06966583,-0.04923511,0.0064803995,0.05429815,0.04069778,-0.005182223,-0.02056035,0.026490126,-0.07083816,0.0058384193,-0.03847148,0.005196032,-0.025942443,-0.022433886,-0.013094699,0.033762176,0.0030877732,0.085887715,-0.0026257078,0.046415284,0.07064509,0.05530229,-0.075295545,0.023960985,0.008050576,-0.08491588,0.05040348,0.036518205,-0.05323494,0.032901816,0.040701415,-0.0033709016,-0.010757319,0.008732882,0.035358883,0.01799918,-0.034705296,-0.057131253,0.0683702,0.029219648,0.058795247,-0.010889232,-0.022060081,0.003175504,0.02846074,0.003266975,0.08131307,-0.040211085,-0.011152932,0.023910645,-0.03188075,-0.03281988,-0.10668314,0.056182086,-0.018364359,-0.026537294,0.034416597,-0.0073533193,-0.042113926,-0.06340036,-0.02202002,-0.08082654,-0.009506112,0.11074403,-0.019976953,0.047742147,-0.042496156,0.016767602,-0.09603005,0.05947964,0.0035747215,-3.5196027e-08,0.029666599,-0.03419378,0.031339727,-0.041156236,0.07090061,0.016007792,-0.003921966,-0.031377003,0.04868107,-0.003804743,-0.00434989,0.13544461,-0.0211303,0.02933926,-0.0036823861,0.0026064448,-0.024012856,0.056096546,-0.0129753975,0.007973857,-0.07477338,-0.011333054,-0.12885442,0.04402372,0.034934055,-0.042992096,0.035893228,0.017637925,0.035903122,-0.11487124,-0.0066208574,0.05095198,0.11990775,-0.054526865,-0.047390886,0.02828999,-0.05129732,0.015213329,-0.048812833,0.11099077,0.0030162418,-0.08831497,-0.04144078,-0.0068846936,0.011886958,0.040356364,0.0740548,-0.009147757,-0.10945678,-0.034695707,0.035204634,-0.044177633,0.024924343,-0.033062205,-0.08055383,0.017404342,-0.058481675,-0.08796342,0.03348017,-0.037350945,0.026069645,0.012896005,0.122521296,0.009059732 +1.2.1.25,"This enzyme system catalyses the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. It belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.104, pyruvate dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.4.1.27, glycine cleavage system, and EC 2.3.1.190, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The reaction catalysed by this system is the sum of three activities: EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), EC 2.3.1.168, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The system also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxopentanoate.",384,0.99999994,-0.04772633,-0.050244164,-0.074967496,-0.10170119,0.13521898,0.0018913612,-0.13812189,0.017702393,0.04344161,0.01644771,0.027903767,-0.04028363,-0.050878607,-0.024994217,-0.0039654346,-0.003942983,-0.083192274,-0.008659952,-0.00630666,-0.07119358,0.053483203,0.03211839,-0.041459776,-0.0069819763,0.022194788,0.052330907,0.036974415,-0.00056017266,-0.08130644,-0.11848657,0.06457797,-0.14707975,0.05017227,-0.024388354,-0.03600048,0.07317352,-0.04228036,-0.071158424,-0.007928555,0.05674675,-0.011882148,0.033695832,-0.012814692,-0.038815305,0.0042479387,-0.05477152,-0.05314577,0.016880585,-0.022713674,-0.020083938,0.04570909,-0.032270156,-0.017179811,0.052553467,0.01319219,-0.02009007,-0.059962016,0.04512346,-0.06283931,0.013251583,0.002777476,0.008956182,-0.019554144,-0.005529269,-0.009374649,-0.034182295,0.081863485,-0.10387351,-0.024756618,-0.032568246,-0.09028267,-0.07177458,0.034210637,0.009378162,-0.0014656957,0.06669477,-0.049247824,0.020877553,-0.007503446,-0.049570873,0.04354105,0.016857086,0.0073920833,0.040494572,-0.012116738,-0.031802278,-0.04595791,-0.018753668,0.04813173,0.034097433,0.040561985,-0.024121266,0.022801144,0.0034345658,0.06866055,0.0705208,0.057421293,0.047785945,0.0050583016,-0.041982602,-0.0297951,0.15121557,-0.036753718,-0.07381746,-0.039053634,0.018916411,-0.008471497,0.12021356,-0.028701603,-0.029792251,-0.0027972239,-0.07081429,9.548123e-05,0.025837192,0.02540274,0.09633153,0.07740371,-0.044787887,0.032715995,0.0017945723,0.12563555,-0.023179328,0.14070415,0.08130073,-0.02131972,0.04384994,-0.14077657,3.9226632e-33,0.026448904,0.014183838,-0.035310075,0.015822724,-0.0013121095,0.0022735465,-0.116427235,0.08935392,-0.030218821,0.016173553,-0.090920106,0.025437897,0.105471715,-0.0061710733,0.0019406804,-0.03216805,0.006662061,-0.037389223,0.028339904,0.0043538236,0.036742605,0.013596451,0.0055115563,0.0337907,0.021386055,0.04337035,-0.0006648595,0.023165112,-0.04473625,-0.0046926453,-0.021237835,-0.11915725,-0.0491173,0.03885264,-0.018599337,-0.0021987553,-0.039105956,0.0023384592,0.066840306,0.03410168,0.035430692,-0.02012239,0.033744216,-0.04437585,0.0029353653,-0.031967506,0.014062361,0.046749413,0.013696246,0.039285284,0.07993133,-0.041178796,0.07008769,-0.06978837,-0.049808122,0.052003175,-0.07002693,0.04032856,0.06652682,0.065444894,-0.005258011,0.06768663,-0.0018835834,0.005587583,-0.0044089155,-0.006631122,-0.107054375,-0.07103476,-0.0071596857,0.033930253,-0.05095429,-0.033555616,0.15038496,-0.011005714,0.05666271,-0.017809357,-0.025927538,0.06377526,-0.007521942,0.020607846,-0.029866416,0.045345113,0.009566267,-0.007270446,-0.016185999,-0.02508712,-0.042580172,-0.018391296,-0.0280391,0.048833985,-0.007808142,-0.012437558,0.006881336,0.0027631049,0.09954324,-4.3492255e-33,0.08785861,-0.07960698,0.021949619,-0.11902441,-0.007973962,0.110809274,0.03780338,-0.037963256,0.046062335,-0.02739956,0.064504296,0.026461454,-0.02710002,-0.04694058,0.077665895,-0.027735872,-0.03623654,0.042266037,0.020159315,-0.0049294056,0.051229317,0.09356148,0.0013935299,-0.0137528675,0.09925844,0.03208815,-0.006088752,0.02946573,0.08896278,0.026432322,-0.04267162,0.012974256,-0.004867866,0.052407652,-0.061551105,0.06788452,-0.06435731,-0.02526674,-0.0014724403,0.017097004,-0.014358433,0.027687926,-0.011898237,-0.0033603276,0.09651953,0.044372074,-0.013524015,-0.0072509884,-0.019890722,-0.07236834,0.014266811,-0.027029242,-0.09075758,0.038282778,0.044540185,0.09793825,0.014910216,0.02693576,0.06971363,-0.039540265,-0.025692374,-0.050503775,0.018012736,0.01702853,0.021098895,-0.062109936,-0.003054613,0.013000638,0.0516012,0.029142035,0.029691081,-0.039171934,0.0050760126,0.027292013,0.0401004,-0.028305551,-0.089365184,-0.050362866,-0.012694744,-0.09259227,-0.037080284,-0.035021693,-0.02179419,-0.062106423,0.013048595,-0.07049134,-0.02566366,0.13133538,-0.0041221282,-0.009786356,0.009815361,-0.03399077,-0.041589655,0.122723855,0.07700195,-4.6649834e-08,0.04930495,-0.019394962,0.041529033,0.017472044,0.034465667,0.012057535,0.04032889,0.0824051,0.023299355,-0.10539597,0.013173014,0.06509017,0.02281383,0.01096124,0.0057242555,0.038240325,-0.040399358,0.06645719,0.0023753021,0.045054402,-0.01197074,-0.052302975,-0.1132738,-0.009510333,-0.024299772,-0.09013486,-0.017217018,0.019034276,0.016012652,-0.01953383,-0.01883966,0.02270886,0.059502844,-0.052668627,-0.039221458,-0.0402129,-0.021566022,-0.019972032,-0.02375904,0.027099404,-0.011202035,-0.085679546,-0.051142674,0.026645124,0.038754568,0.042321675,-1.0268901e-05,0.020600034,-0.045530897,-0.013165076,0.018055107,-0.011505653,-0.011956478,-0.031638764,-0.05951546,-0.03663373,-0.025562845,-0.11673624,0.060873803,-0.06740711,0.00072851684,0.047976892,0.12514052,-0.0004291608 +1.2.1.27,Also converts 3-oxopropanoate into acetyl-CoA [3]. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding [3]. Bicarbonate rather than CO2 is released as a final product [3].,384,1.0,-0.047486186,0.0012945613,-0.078182526,-0.010686141,0.07667309,-0.02137476,-0.08614967,0.013704402,0.023231745,-0.008572161,0.0050726077,-0.101367444,-0.115969546,-0.04957825,-0.013476367,0.09472487,-0.03794079,0.035971902,0.038328707,0.0240202,0.058670238,-0.008584523,-0.009969421,0.0053784917,0.0629492,0.03155845,-0.0042481404,-0.008597484,-0.0038311256,-0.06255277,-0.013872857,0.030910125,-0.014474962,-0.023226341,0.020634739,0.032058068,0.006276788,-0.050792456,0.0489512,0.06821291,0.030746197,-0.0483705,-0.024801834,-0.0359851,0.028629506,-0.0066289944,-0.033268653,-0.0010085375,0.010786627,-0.018046528,0.0005226638,0.037963334,-0.12708668,0.024443273,-0.047114294,-0.008030627,0.009437422,0.025672555,0.008574072,0.014263079,0.017343683,0.02799999,-0.074485235,0.025026511,0.044804864,-0.068234,0.04457662,-0.09689006,0.02039552,-0.0070443912,-0.05252605,-0.037513833,-0.020412816,-0.034006126,0.038341872,0.015270781,-0.010732727,-0.047263753,0.05433735,0.037454937,0.049215592,0.094209254,-0.014477812,0.032574914,-0.014044069,0.047721196,-0.09059369,-0.026262065,-0.024890874,0.023712162,-0.065337636,-0.010954619,0.011337592,0.013164836,-0.042116765,0.07393488,0.08609651,0.022897527,0.05679713,0.033531014,-0.013103706,0.0840139,-0.023421386,-0.15851918,-0.053707965,0.01913645,0.027727934,0.10257089,0.0510783,0.07215906,-0.061547022,-0.054117437,0.045167584,-0.008997907,-0.0096517345,0.18076381,-0.028078284,-0.05135535,0.027192557,0.054766867,0.038034957,-0.011215767,-0.013044675,0.061110098,-0.01308758,0.011338596,0.023245426,3.7715317e-33,0.056580298,0.0570185,0.04425125,0.031837557,-0.008460354,-0.028382232,-0.09736738,-0.077956274,-0.021693988,0.00832091,0.027384385,-0.018587084,0.06444856,0.072965644,-0.08329864,-0.0715512,-0.041665982,0.02741745,0.022213923,-0.008506149,0.017398326,0.08323669,-0.04001083,0.08794348,-0.024358626,-0.009121182,-0.04055219,0.053811748,0.03489197,-0.0031583474,0.043112732,0.022656815,-0.052286066,-0.02583532,-0.003267785,-0.04708661,-0.050194815,-0.0745147,-0.01826441,0.09866011,0.05596912,0.006706748,-0.054905735,0.010578785,0.022830602,-0.059844602,0.0060924585,0.094441056,0.04233162,0.011627676,0.015186352,-0.0055732643,0.026336422,0.04678805,-0.04861701,-0.00058331207,-0.025626654,-0.032337803,0.09279808,-0.021313518,0.005964093,0.046813376,0.029877974,0.0118338,-0.013866662,0.0022649374,-0.05219273,-0.01477241,-0.0039434144,-0.025103046,-0.03899613,-0.034332387,0.010516869,0.04239895,0.08740145,-0.050283875,-0.009760471,0.03681224,0.062039077,-0.050066534,0.031196365,0.024569936,0.022694487,-0.06162961,-0.00897931,0.008810505,-0.013187852,-0.052552514,0.016223233,0.0761441,0.03101155,-0.032204315,0.0004976538,-0.014632098,0.009759312,-3.4632822e-33,0.07922129,-0.1134767,-0.051812224,-0.09339417,-0.07627715,0.008219472,-0.028470889,-0.08108692,0.0072374986,0.0069776336,0.10510495,-0.031526625,0.040250264,-0.011530758,0.033698186,-0.048853338,0.042483628,0.018790223,0.0039973594,0.04020765,0.12541524,-0.03228624,0.0038861292,0.025124302,0.036582116,-0.018260757,-0.041764587,-0.01681805,0.12030428,0.043114573,-0.037557248,-0.035064798,-0.016004855,0.035432898,-0.064266205,0.011889545,-0.017631445,0.062246244,-0.05259792,-0.030162927,-0.056457236,-0.051763438,-0.024302233,0.0132491,0.08921834,0.0074334056,-0.032628696,-0.035583846,0.02570101,-0.043069225,0.018907193,0.03800011,-0.10318682,-0.010080855,0.020839142,0.10382009,0.009256164,-0.07610378,0.0744912,-0.060038023,-0.073526435,-0.021256203,0.031841986,-0.08868183,0.12519385,0.11111849,-0.028510148,0.08278496,0.046684455,-0.014990699,0.07895061,0.07551145,0.052013583,-0.036728516,0.047687028,-0.14672607,-0.013301326,-0.06913169,-0.10021851,-0.096877486,-0.0790226,-0.032724913,0.06214029,-0.018590976,-0.104124315,-0.077793196,0.023985302,0.053663068,-0.07404837,0.0077523687,-0.009005542,-0.007610599,0.028279798,0.084123045,0.058985308,-3.520349e-08,-0.049837817,0.024923695,0.082624935,0.039644755,-0.034022503,0.08531567,0.08766445,-0.0012507401,0.010675754,-0.06537199,-0.043797262,0.073984556,0.116899505,-0.02277763,0.08408261,-0.0055672666,0.011210263,0.036577202,0.0068587027,-0.091414705,-0.05067412,-0.077801295,0.019723315,0.008984238,0.010683027,0.0017993924,0.033379123,0.099319816,-0.042045377,-0.010545724,-0.059567723,0.027373144,0.0028752794,-0.037102535,0.025746284,-0.06011342,-0.0201996,-0.014284357,-0.044848446,-0.027284238,-0.018116465,0.057658277,-0.08101194,0.032398183,0.043629035,-0.032801677,0.05005737,0.0019007426,0.03291539,-0.037698742,0.096418664,-0.028714603,-0.032098547,-0.01680183,-0.016196981,0.0034154002,-0.01877031,-0.038350657,0.029007755,-0.017292807,0.004430422,0.0117106745,0.11614984,-0.0134486845 +1.2.1.29,"Oxidizes a number of aromatic aldehydes, but not aliphatic aldehydes.",384,1.0,0.04230027,-0.06779972,-0.010078195,0.06261612,0.079652555,-0.0036921618,-0.043712486,-0.08838943,0.09418454,-0.02573155,0.04370842,0.04966511,0.010704796,-0.0034771839,-0.038290597,0.06117407,-0.05681,0.025742183,-0.06259257,0.023078954,-0.0629818,-0.017450184,0.027762922,0.046221957,0.04408025,0.037350528,-0.032415733,0.046113472,-0.0014505925,-0.081899375,0.05089023,0.052724022,-0.0818451,-0.03664543,0.018617123,-0.045302365,-0.06664904,0.043061744,0.0421771,0.039789733,-0.028422805,-0.002385631,-0.06967689,-0.03143243,0.0059180427,-0.015313078,0.0202918,-0.009528089,-0.10064101,-0.0040665655,0.0056192805,0.03300027,-0.12745787,0.057139333,-0.0075154575,-0.05055481,-0.042497955,0.04612011,-0.066477284,-0.006179352,-0.03526658,-0.01444899,-0.027236897,0.04989837,-0.079720765,-0.029391201,0.04483105,-0.028672384,0.0064520356,-0.026053041,-0.08886417,-0.07572385,-0.03937299,0.058950692,0.03668679,-0.02874484,-0.019014113,-0.07289411,0.060522813,0.032528512,-0.06771562,-0.013500868,0.016718937,0.074038655,0.06371032,-0.053117413,-0.031908903,-0.018013353,-0.09881672,0.03686698,-0.062366083,0.025154911,0.056758564,-0.050826624,0.020666964,0.02192558,0.117993504,0.118745655,-0.006763324,-0.0023713293,-0.027157785,0.05005457,-0.08084684,-0.10435587,-0.021016216,0.00050608657,0.03668188,0.044431195,-0.025109988,-0.06586602,0.03378417,-0.0098718405,0.057022322,-0.05220954,-0.06201885,0.046184473,0.068196304,-0.061935835,-0.08905928,0.034211434,-0.026789725,-0.008676645,0.030399868,0.047467954,-0.078660734,0.008750609,-0.008270179,9.75083e-34,0.03395229,-0.05698551,0.0443425,0.022038355,0.03040728,-0.0012546622,-0.089144416,0.017039653,0.105829485,0.010670922,0.017448554,-0.0233686,0.025884807,-0.021728981,0.09029694,0.06488565,-0.06538347,-0.03386644,0.02128615,-0.036077775,0.039333425,-0.0145602375,-0.06544036,0.03333657,0.0077063306,0.0021078873,0.0022070294,-0.027016636,-0.08676332,-0.013580717,0.022901844,0.040814854,-0.099313356,0.0065363282,-0.070054315,0.010613085,-0.048159305,-0.043379117,0.0335949,-0.05618673,-0.043536976,0.037764672,-0.013454567,-0.053217653,-0.013624845,-0.023515288,-0.026800685,0.13214974,0.04516174,0.042411983,0.053068414,-0.0025977239,0.07368353,0.040052965,-0.046285924,0.064582385,-0.00954013,-0.052515782,0.0060876776,0.035827044,-0.0094376365,-0.014750357,-0.09269258,-0.032142505,-0.019350592,-0.0030042252,0.0019532396,0.077571385,-0.0225864,0.0064671454,-0.009674961,0.010296094,0.076730676,0.0050503346,-0.019105816,0.0035523367,-0.07566939,0.029180994,0.086467795,0.039013214,0.013981451,-0.05538129,0.035616197,-0.023552826,-0.031948704,-0.013875256,0.007998412,0.10981924,0.02501327,0.013104133,0.04088251,-0.06472403,-0.019805314,-0.05478665,0.024458274,-3.6614496e-33,0.05481358,-0.010307709,-0.053709555,-0.016299676,-0.013598859,-0.008780262,-0.0018758391,0.017017618,0.033910252,-0.025382075,0.06476442,0.0397898,0.0022607627,-0.01318708,0.032701604,-0.03716745,-0.0060103857,0.037062433,0.035153665,-0.017967736,-0.0049104234,0.023093017,-0.068179205,0.0047052554,0.044026744,0.008187587,-0.089260675,-0.029658668,0.112172864,0.043724254,0.008497346,0.025459576,0.011187066,-0.07336011,0.040226605,0.03437248,-0.051784202,0.03943977,-0.12993704,0.052315045,0.03337586,-0.007634545,0.04029432,0.083708934,0.061195977,-0.0070626554,-0.12548995,-0.058043595,0.025818242,-0.05062591,0.05291892,0.07976801,-0.07801528,0.0064091985,0.038292266,0.09990083,-0.021033019,-0.059124872,0.026557948,-0.04392586,-0.054190535,-0.00850628,-0.022038532,-0.06642648,-0.10738784,0.018892663,-0.06561001,0.05915864,0.035212465,-0.03970287,0.085364506,-0.019079711,0.022867236,-0.07886637,-0.0091262115,-0.069597825,0.021739963,0.024053657,-0.025571961,-0.03493938,0.06606597,-0.003294087,0.02541501,-0.04936403,-0.027404586,-0.02604664,-0.049099356,0.001665621,-0.027535958,0.0478993,0.0063244663,0.008065636,0.11194251,0.061123136,-0.00016059441,-2.510001e-08,-0.069364674,0.066012494,0.15227695,0.042444076,-0.076819204,0.0047222087,0.09328891,0.058122925,-0.02196106,-0.031564824,0.07677801,-0.0026593213,0.047598787,0.038492166,0.081592254,-0.015491471,-0.04563799,0.009887604,-0.0021643143,-0.045109242,-0.12317385,0.022890987,-0.028835941,0.061525315,-0.005228471,-0.0014504169,0.032386467,-0.11289265,0.03361693,-0.0132391,0.022458179,0.06884605,0.010955614,-0.024206437,-0.09344975,-0.021042462,0.040905103,-0.05777237,-0.062885635,-0.035381272,-0.065455765,-0.083290674,-0.076395534,0.023604166,0.12828389,-0.01912156,0.006094731,-0.028229652,-0.019465292,0.014698343,0.111231215,0.015372778,0.005335075,-0.012848334,-0.04876535,0.02371268,0.04238931,-0.014945982,0.03726313,-0.07153251,0.06931363,0.017420392,0.14218128,-0.012677828 +1.2.1.30,"The enzyme contains an adenylation domain, a phosphopantetheinyl binding domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the phosphopantetheinyl binding domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to an aldehyde and released.",384,1.0,-0.036000438,-0.060361285,-0.08099249,-0.0043539535,0.029853977,0.02334478,-0.021531258,0.0114316745,0.022758622,0.019629346,0.008221851,-0.036180165,-0.06973177,0.0025775242,0.011529299,0.073520504,-0.06749514,-0.013945328,-0.025951277,-0.0681082,0.08781792,0.022654008,-0.03052273,0.02278646,0.035361018,-0.026624374,0.052788038,0.00046233268,-0.030433824,-0.04629557,-0.050885864,-0.0072325855,0.033386115,-0.04792588,0.017086502,0.15800092,-0.04054799,-0.084457226,-0.044831328,-0.021586675,0.079869814,-0.0656978,-0.049266323,0.034845483,-0.116333015,0.007627803,0.04106126,0.11446334,0.031710528,0.04922628,-0.029445143,-0.09876006,-0.05317984,0.035494,-0.08314659,0.09554399,0.016290406,0.038467787,-0.0538637,0.013374202,-0.020936577,-0.008557389,-0.027696768,0.07041765,0.059881914,-0.037598327,0.06133771,-0.021928905,-0.036236163,-0.04434151,-0.019659512,-0.048216518,0.005186707,0.026512101,0.09535681,-0.039118763,-0.0066191033,0.0011290874,0.03865936,-0.03728066,0.059376128,0.04910438,0.06500595,0.07423933,0.033550005,0.014136578,0.009243358,-0.03133301,0.028792955,0.015451594,0.041647963,-0.058950964,-0.062265858,-0.051691107,-0.039848574,-0.013246526,0.038112298,-0.0018124385,0.0486556,-0.023388766,0.039610468,0.033475935,-0.031197399,-0.04063391,-0.05876236,0.023548944,-0.027590055,0.0446729,-0.03473435,0.017554073,0.004328693,0.04293949,0.10103258,-0.010913343,-0.040788405,0.104556516,-0.039880697,-0.0964405,-0.06256225,-0.044845108,-0.017747523,-0.010679209,0.06131011,0.100532554,-0.045523264,-0.04244671,-0.140356,2.8819549e-33,0.06266571,0.06170233,0.016378874,-0.041717727,0.023216413,-0.011297705,-0.05874875,0.010995884,-0.07524488,0.002844261,-0.049446855,-0.04270616,0.038271442,-0.008188793,0.013807532,-0.041656397,-0.03182306,0.076736316,0.06834694,0.06734048,-0.02283308,0.061800078,-0.092971236,0.049919926,-0.052760046,0.09771576,-0.05487434,0.08109737,-0.020467991,0.01570303,0.0025394866,-0.078652404,-0.069191836,-0.013605428,-0.0040223124,-0.024314374,-0.05640243,-0.046904,0.008335423,0.037933975,0.027237704,-0.0005565922,-0.01975836,-0.0063379696,0.007877922,-0.12044794,-0.01781609,0.07664302,0.024873806,0.053531867,0.02645021,-0.08032437,0.13383673,-0.061893955,-0.08064537,0.042709056,-0.07842257,-0.05088695,-0.021296028,-0.00094354135,0.06444115,0.02749821,-0.039402854,0.06309206,-0.038661394,0.025234286,-0.053677823,-0.09074719,0.0109570995,0.12578833,-0.07044893,0.06333702,0.015641283,0.026411047,0.015946794,-0.016401691,-0.056084268,-0.0013850403,-0.0050529977,-0.0007723932,0.02044751,-0.031049957,-0.02487475,-0.03608837,-0.017219922,-0.063858256,0.02343175,-0.052051127,-0.041654497,-6.573595e-05,0.048816223,-0.09047933,-0.017704943,0.023575624,0.11261723,-4.574651e-33,0.12804824,-0.070246905,0.029432023,-0.05285392,-0.03401729,0.030825052,0.019896697,0.00017183347,0.011105608,0.009644212,0.06334727,0.008586084,-0.05450436,-0.06450666,0.02782635,0.009750386,0.058164004,-0.017571732,-0.037884768,-0.07541241,0.0003790943,0.012085934,0.033953343,0.034300927,-0.016586712,-0.04507275,-0.069524206,0.061686784,0.032483317,0.078321,-0.050013375,-0.04846174,-0.063434996,0.0027231122,-0.02038378,0.057354614,-0.072033755,0.032115586,0.014056445,0.046305593,0.07743795,0.011952173,0.005244942,0.060780074,0.0027074285,0.08930404,-0.11113789,0.029637583,0.02832734,-0.11701077,0.05873481,0.027669372,0.04053176,0.02826076,0.018411342,0.103160344,0.027983403,0.009017698,-0.027696947,-0.018860564,-0.051252153,-0.06631581,-0.0043209353,-0.024543492,-0.010070944,-0.026791904,-0.044043913,0.042216282,0.031060439,0.04667319,0.03929897,0.048079703,0.011176807,0.029394783,-0.033341814,-0.044171806,-0.03513364,-0.05323758,-0.030831564,-0.04964711,0.0325209,-0.035199627,-0.011570317,-0.068112776,0.017995492,0.020912288,0.036823872,0.07645027,-0.024440601,0.03468547,-0.0025476424,0.0068285265,0.003659138,0.021408113,0.011479894,-4.271901e-08,-0.015447918,-0.04972677,-0.000679453,-0.079339206,0.0035513195,0.060763206,0.043387793,0.009548384,0.023717059,-0.013528747,-0.07515176,0.084606156,0.0060074767,0.023229007,0.075024866,0.056164745,-0.0256843,0.035375115,-0.0077251294,-0.08321772,-0.04695188,-0.0368621,-0.10357534,0.071789086,0.033157002,0.026939355,0.06328399,0.031808354,0.007577526,0.064089835,0.038372703,0.02778037,-0.06483595,-0.011976874,-0.060589958,0.040520392,-0.030443592,-0.008518841,-0.05529284,0.004647943,0.033930313,0.03185371,-0.077110425,0.021343129,0.01672106,0.04849526,0.05452969,0.045882873,-0.0018963211,0.05365673,-0.007787177,-0.027914846,-0.018150445,-0.032399476,-0.087669164,-0.041366678,0.01104379,-0.07445588,0.0036011783,-0.041999962,0.06259057,0.036282904,0.22165543,-0.052118763 +1.2.1.31,"(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.",384,1.0,-0.021993648,-0.07522297,0.00054909766,0.0068444517,0.12214277,0.03113344,-0.00013901698,0.0048787086,0.032302275,0.007879738,0.029647699,-0.09279161,-0.12420409,-0.0103656,-0.031455144,0.013179381,-0.09474996,-0.034481946,0.065340444,0.018298427,0.030769233,-0.07197756,-0.0065246816,0.035067126,0.07952396,0.05259713,0.10312453,0.021426972,-0.034066007,-0.037816625,0.051478002,-0.007054414,-0.03085422,-0.06919604,0.0718958,0.09327792,0.0033310147,-0.041841563,0.0018101545,-0.026748719,6.686447e-05,-0.06614524,0.020891234,-0.022446021,0.011914612,-0.0037598643,0.07009735,0.04677205,-0.020103911,-0.0101197595,0.07544355,-0.0322716,-0.033328634,0.015573271,-0.013298214,0.033720806,0.013467484,0.04618101,-0.029404484,-0.027484182,0.078833975,0.015807595,-0.038004734,0.008329287,0.036194347,-0.06417557,0.022639759,-0.04971599,0.040140178,-0.05353357,-0.0418348,-0.053699356,0.04186903,0.018531498,-0.008926269,-0.04523276,-0.02120702,-0.08295735,0.06682197,0.037209135,0.05599729,0.02877023,0.051138666,0.043892924,-0.0056244954,0.024489408,-0.0003720483,-0.01716573,-0.017182851,-0.045774117,-0.039481997,-0.013088441,-0.034607325,-0.025933212,-0.09548414,0.104997426,0.06704509,0.05458953,0.09572181,0.048079107,-0.0016441334,0.06735591,-0.05446733,-0.10135295,0.016367238,0.018751899,-0.017881822,0.10001973,0.008779542,0.013815448,-0.035087593,-0.045118734,0.0253111,0.036742657,-0.07382691,0.098369054,-0.022044681,-0.01636942,0.014580427,-0.0034403678,-0.014334272,0.036139462,0.018291228,0.059080098,-0.031879432,-0.020324446,-0.063504264,-1.062011e-33,0.053061303,-0.04231046,0.04404621,0.041960686,-0.02438634,-0.06808882,-0.09036995,-0.052547444,-0.00379814,-0.029620105,-0.1105882,-0.105756834,0.08665726,-0.05002168,-0.059475575,-0.09727152,-0.07745414,0.027801234,0.014238284,-0.0103281615,-0.036961008,0.09580943,-0.025764827,0.055460703,0.036665723,0.021487786,0.019343458,-0.042582955,0.1056479,0.009537196,-0.024918942,-0.017700681,-0.051549684,-0.005414582,0.08523638,-0.046392422,-0.072948396,0.007342004,0.07897986,0.05800045,0.05886071,-0.017003877,-0.026217923,0.004452287,0.03922651,-0.020577244,0.057062056,0.12734064,0.027101371,-0.029137006,0.02889055,-0.046082765,0.04786414,0.020916298,-0.033382073,-0.009271406,-0.009697619,-0.015005285,0.09751559,0.012666171,-0.0033874866,0.091979116,-0.014191597,0.016316164,-0.005453161,-0.033624995,-0.0889022,-0.04721369,0.052013483,0.004329058,-0.06989997,0.032132156,0.13134536,0.015166429,0.05072215,-0.04306516,0.035466067,-0.024616165,0.041081775,-0.010947331,0.044290397,-0.026208445,0.04905318,-0.007701794,-0.03999725,-0.01581733,-0.06881662,-0.048758324,-0.02877048,0.118756995,-0.0011449446,-0.07582154,-0.052126482,-0.051073745,0.057595156,2.5152333e-34,0.06752308,-0.039872013,-0.08449278,-0.03616389,-0.0030728655,0.01526837,-0.0021269447,-0.03311542,-0.0073782327,-0.011317319,0.05783317,0.012789489,-0.012033609,0.011528431,-0.002601228,-0.022228802,0.010924375,0.013425584,0.045685224,0.0004171854,0.08375484,0.009638334,-0.032662496,0.009217934,0.08121045,-0.0026589378,-0.010339799,0.023028858,0.105338156,0.082123384,-0.030842343,-0.10297838,0.01981297,0.014229543,0.013857199,0.068667166,-0.018568667,0.010249803,-0.07528427,0.08985177,-0.06721122,-0.044780664,-0.0015859944,0.05701356,0.06476492,0.03372311,-0.11059716,0.00538053,-0.011359691,-0.024018371,0.009320004,-0.07337666,-0.11823001,0.0028074216,0.01796525,0.020349877,0.049303446,-0.008196093,0.0040589585,0.018906033,-0.026711717,-0.086881295,0.053905897,-0.07747016,-0.009921857,-0.009114567,-0.039930336,0.041246336,0.053777806,-0.039581474,0.06863159,-0.014053267,0.0021456955,-0.021450466,0.044494435,-0.104196645,0.009691579,-0.015033741,0.045147967,-0.09241544,-0.04960185,0.02397134,0.025430687,-0.0069535696,0.0007766658,-0.05756028,0.02195201,0.09070239,-0.05484543,0.060955238,0.057189576,-0.02291686,-0.00072616024,0.1281545,0.006996225,-3.854766e-08,-0.0037967481,-0.07276689,0.07662248,0.030371187,0.034744263,0.0892008,0.117425926,0.022879777,0.045896117,-0.15763275,0.023206115,0.049891353,0.054672327,-0.014700939,0.061107032,0.0043038353,-0.010154694,0.040605184,-0.088552654,-0.032013074,-0.02474652,-0.04078063,-0.1128362,-0.04336224,0.0045281653,-0.006721682,-0.003166283,0.07067819,-0.06861898,-0.058808643,0.0134979505,0.0434039,-0.039581753,-0.026464606,-0.058049414,0.029030146,-0.051208176,0.029514603,-0.068877205,-0.051423818,-0.036430016,0.036556304,-0.044668324,0.011033778,0.007842297,0.002534783,-0.037238933,0.054479897,0.0020912464,0.060973093,0.04510039,-0.018983675,-0.04468359,0.0045891125,-0.036237665,-0.013782181,-0.0060333437,-0.07167532,-0.02735602,-0.0528041,-0.024961587,0.0781771,0.12168227,-0.00018815385 +1.2.1.32,Also acts on 2-hydroxymuconate semialdehyde.,384,1.0,-0.007913634,-0.071792305,-0.028941032,0.007766926,-0.0010926441,0.03997169,-0.060687482,0.01285963,-0.02263919,-0.040337957,0.022369184,-0.030136188,-0.043368094,0.091668464,-0.031895302,0.057892628,-0.021464864,0.022420326,-0.0067679547,-0.008473403,0.03669851,-0.014409192,0.055210955,0.019997617,0.054840308,0.031199625,0.04384054,0.05310567,-0.02237408,-0.08040039,0.018701099,0.06097463,-0.087859675,-0.04475297,0.037910007,0.04284788,-0.05647901,0.03194338,0.05362824,0.0022770509,0.073929064,-0.088796854,0.02265999,-0.04872828,-0.0070044165,-0.019139593,0.014814819,0.04433039,0.03908021,0.044387273,-0.07407929,-0.060417704,-0.031028803,0.06409357,-0.029059688,0.017990444,-0.0820172,0.04624076,-0.0150576625,0.030936169,-0.054557104,0.012786576,-0.071805224,0.047169298,-0.016488658,-0.08944469,-0.027507586,-0.06043981,-0.015319485,-0.0031847262,0.009259342,-0.11260035,0.067361414,0.053269528,0.033254825,-0.059122227,-0.021322714,-0.06541059,0.024439216,-0.009057651,-0.050029445,0.0039105397,0.04752325,0.094059095,0.02938243,-0.045416936,0.048374567,-0.019615633,-0.006733868,0.008024954,0.04303773,0.028677233,0.026892811,0.05025679,-0.03775642,0.014608835,0.012031885,0.09266052,0.013284189,-0.045947,-0.07050796,-0.032886285,-0.037393365,-0.0797509,0.011613837,0.006998371,-0.00082173594,0.048301585,0.03578993,-0.060352884,0.00546067,0.0057515376,0.03856959,-0.007913067,-0.017694129,0.081061564,0.12531558,-0.011017202,-0.05524617,-0.045611247,0.0034564468,-0.07938821,0.07935519,-0.021629108,-0.073427446,0.07963818,-0.012008018,2.577728e-34,0.044613585,-0.03216357,-0.004694758,0.012865822,0.054873154,0.007906188,-0.12045438,-0.008435266,-0.029665451,-0.046351857,0.020069893,-0.013195748,0.0020064649,0.071449146,-0.0925908,-0.041803382,-0.015377408,-0.008169738,0.052868046,-0.016875073,0.054822356,0.13032459,-0.061832342,0.036246113,-0.06309665,-0.022785155,0.044703107,0.010515826,0.0374235,0.0036602204,0.06640289,-0.059978183,-0.08647956,-0.030733917,-0.023285635,0.08036464,-0.052610923,-0.024249488,-0.0088818595,0.005591272,-0.005366743,0.015619199,-0.019665008,-0.09685003,0.03836439,-0.0639234,-0.083374165,0.08359458,0.04087761,0.031042855,0.08887015,-0.02772382,0.09353344,0.068604566,-0.038274966,0.068315804,0.026773289,0.018225387,0.060556166,0.05033365,-0.04521554,0.022474883,-0.07023023,-0.013861496,0.008513789,-0.04397557,-0.027630812,0.005610254,-0.051491722,0.013626975,-0.08831988,-0.0017506069,0.13923404,0.024410184,0.028083868,-0.07433464,-0.021649474,-0.0063248198,0.058855478,0.028510518,0.015243521,-0.046176203,0.07032606,0.047755964,-0.085102305,-0.030166466,-0.0437245,-0.04003965,-0.053314097,0.051444907,0.0721506,-0.061491773,-0.051583856,0.012102218,-0.0047240783,-2.31233e-33,0.08057528,-0.10404699,-0.02923477,0.038095377,0.0025565275,-0.0040997034,0.03405482,0.029067446,0.004740815,-0.019276224,0.13676266,-0.03201617,-0.04243851,0.004935515,-0.0119242305,-0.0089724455,0.05617967,0.0877713,-0.02657867,-0.01268824,-0.0015737362,0.10801432,0.02556067,0.10112878,0.068496905,0.0088108,0.02713829,0.023983872,-0.008498634,0.0908122,-0.008496348,-0.04990369,-0.079097696,-0.10488619,-0.006449684,0.04863181,-0.070402466,-0.06138742,-0.03720264,-0.0058272867,0.025110316,-0.060863603,0.013081788,0.11816408,0.08053906,0.10335001,-0.061491545,0.03351333,-0.054503046,-0.0062209745,-0.025895573,-0.011702968,-0.070639215,0.062396985,0.028420841,-0.014340612,-0.005833625,-0.0681083,0.029403597,0.015686978,-0.014818955,0.014171166,-0.02065166,-0.10050473,0.040984597,0.014099082,-0.14223869,0.036646288,0.09947078,0.016710334,0.08854081,0.004374665,-0.014901852,0.015865957,-0.03726468,-0.053626195,-0.020959778,-0.070982605,-0.013653714,0.011655269,-0.018859642,0.001282177,-0.003446601,-0.036401354,-0.0039950805,-0.090072736,-0.024565617,0.07310718,-0.058054443,0.05146654,0.023546465,-0.0029772404,-0.027272094,0.038781762,0.060166217,-2.2817508e-08,0.01171807,-0.05847016,0.12280851,-0.03731414,-0.06440657,-0.03812832,0.06686478,0.04493408,0.031443924,-0.045794953,-0.041679204,0.11741042,0.052787013,0.07362476,0.0254238,-0.009041543,0.020802293,0.024304418,-0.061066005,-0.063422784,-0.10402333,-0.041113727,-0.034910508,0.053280268,-0.061081953,-0.021668907,0.022859901,0.017142465,0.03456851,-0.049605682,0.033554778,0.011203643,0.0014074632,-0.009678967,-0.05406294,0.066876054,-0.062779,-0.04332646,-0.0030317304,-0.0011342956,-0.012697838,-0.08516291,-0.03428547,0.013112509,-0.001076037,-0.030917909,-0.032794215,0.032315105,-0.021174097,-0.031655844,0.07537403,-0.025745912,-2.1031143e-05,-0.0051820274,-0.064874016,0.042216893,0.017220104,-0.068194486,0.09332939,-0.07783136,0.031323854,-0.002891854,0.12923943,0.01171431 +1.2.1.36,A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.,384,0.99999994,-0.060295887,-0.06917486,-0.040013462,0.035574745,0.031037714,-0.013480262,0.07478747,0.036703434,0.0072278096,-0.009523277,0.0102300625,-0.036286477,-0.06125246,0.01713949,-0.074511126,-0.057638124,-0.05654576,-0.024700532,-0.074690364,0.016779622,0.028759614,-0.08018169,0.055193815,-0.07637783,-0.030949416,0.027594643,0.017499762,-0.04756538,-0.027179163,0.020957842,0.014029052,0.048551932,-0.058760446,0.027937459,0.014922874,0.01281532,-0.0016564823,0.0128797805,-0.0748303,0.013233096,0.016504722,-0.0144757815,0.022856586,0.014624488,0.15006647,-0.025311496,0.025807615,0.03923746,-0.032741334,0.06177474,-0.019115377,-0.059766024,-0.07399465,0.07487591,0.055647198,0.06602325,-0.081882685,-0.020900857,0.09847171,0.05973138,-0.014445685,-0.060157675,0.054712564,-0.0018567101,0.019205347,-0.04647712,-0.040302936,-0.052521225,0.0708518,-0.01896202,0.031969115,0.023383513,-0.06509399,-0.024658246,0.010334314,0.07632848,0.019065896,-0.0891633,0.072575964,-0.0484012,0.12142633,0.07687398,0.11161967,0.011951589,0.12631766,-0.026267607,0.0020756049,-0.008122505,-0.1252449,0.05396157,0.0011330742,0.017523067,-0.02751174,-0.031252664,-0.0935107,0.024701579,0.021699408,-0.041794676,-0.08712864,0.02239828,-0.031432062,-0.0076547447,0.06624374,-0.0029037897,-0.077035844,-0.053267673,-0.024036877,0.108306,-0.088085465,-0.031010544,0.006206865,0.014896552,-0.02089253,-0.021334447,0.061635535,-0.006329484,-0.04394358,-0.020358816,0.10794649,-0.020551648,-0.096625976,0.067603186,0.05042949,0.06397371,0.059464745,-0.0120285135,-0.06069384,-1.4829884e-33,0.053101677,0.007158101,0.009815608,-0.009185339,-0.00028855324,-0.009466651,-0.02260293,0.017378727,0.003583398,-0.011697016,-0.025599629,-0.030770019,0.0027398719,0.00018951489,0.018693306,-0.018143456,-0.028154003,-0.030699594,0.025931198,-0.1353715,-0.038182348,0.10555364,-0.007099016,-0.05558353,-0.038068112,0.004581534,-0.09679343,0.0008926087,0.05518238,0.05812011,-0.025253002,0.02613502,-0.038248096,0.0034141545,0.0075215474,0.059956275,0.059901062,-0.09378438,-0.049652908,0.00089347624,-0.018794475,0.003824515,-0.059027687,-0.033992924,0.08542668,-0.010840278,-0.08176499,0.08288303,-0.08267896,0.04704441,0.03630829,-0.0014046638,0.06139682,-0.009866381,-0.10036503,0.02539482,-0.04353572,0.036689024,0.037368514,-0.013114685,0.03414427,0.005982128,-0.02244538,0.1384179,4.0032995e-05,-0.018046279,0.004429135,-0.046576444,-0.054387923,0.06499241,0.06881325,0.043485966,0.083966374,-0.027010774,0.050605297,0.04231559,-0.064710096,0.015664136,-0.020113833,0.061608464,-0.052086562,0.016678892,0.014108302,-0.04903828,-0.0058191526,0.025998358,0.008830216,-0.027501388,0.026134485,-0.048340242,0.065368235,-0.0016667165,-0.009280436,-0.034373995,0.032854144,1.2376229e-33,-0.0072949165,-0.07505073,0.02962297,-0.009803027,-0.06732435,-0.008753189,0.0073363385,-0.028193057,0.064815596,-0.034816567,0.055831343,-0.07583661,-0.03542014,-0.044286784,-0.018746642,-0.049141947,-0.08434735,0.10385346,0.040947706,0.03804364,-0.053053867,-0.048446726,0.033993483,0.102226086,0.040677343,0.017726498,0.03922672,-0.015131126,-0.047151763,0.03771435,0.008647317,0.03507634,-0.023274401,-0.043225445,-0.05259623,-0.01770247,-0.06457353,-0.05246013,-0.018918347,0.061716635,-0.016805729,-0.009895424,0.056549508,0.044882193,0.04988476,0.060631186,0.00287722,0.08857489,0.09846369,-0.030876562,-0.061573617,-0.022737762,0.0079689985,0.007992215,-0.018626072,0.060895715,0.08250386,0.04417902,0.014113141,0.038626287,0.02977112,-0.09316813,-0.012616533,-0.035231337,0.11339719,0.08645998,0.09291261,0.06394956,0.04008372,-0.008800876,0.16677241,-0.030768035,-0.036712177,0.03945739,0.01695505,-0.099993326,0.047166254,0.121300556,-0.012415887,0.059798595,0.049346365,-0.035290346,-0.027375896,0.075263165,-0.021360843,-0.069640994,0.034964524,0.053962857,-0.024922168,0.002769872,-0.06273763,0.01986964,-0.04176059,-0.012867193,0.003934452,-2.6557261e-08,0.024144044,0.006112284,-0.0024552385,-0.07813863,0.06597018,0.027567176,-0.06267976,-0.024210682,-0.043079056,-0.05023888,-0.010641088,0.050146036,-0.024784567,-0.024550423,0.04906653,-0.00058952457,0.050163403,-0.0071853013,0.00082455034,-0.0034098427,-0.048054077,0.0014922114,0.040071383,0.02844703,-0.12054174,-0.0011273948,-0.0070090373,0.021467945,-0.013379235,-2.8907585e-05,0.03458013,0.023929054,0.046246685,0.028708236,-0.10666689,0.05010828,0.052338023,-0.020085536,-0.04755777,0.054978963,-0.109944455,-0.039584912,0.05258244,-0.027384534,-0.04144597,-0.029029941,0.05751705,-0.013333231,-0.033240885,-0.026610438,-0.0885895,-0.0187005,-0.012358584,-0.021721248,-0.096621655,-0.035692543,0.00676838,-0.034618504,-0.03759326,-0.050339546,0.0530586,0.068465985,0.029249964,0.036246665 +1.2.1.42,"Also acts, more slowly, on octadecanoyl-CoA.",384,1.0,-0.009933387,-0.1206586,0.040501516,0.07559234,0.039371945,-0.0119750975,-0.062092785,0.022645213,0.07679132,-0.035603896,0.07220903,-0.041860346,-0.101089396,0.056185503,0.03816523,-0.011724147,-0.008225024,-0.020065635,-0.0027819108,0.08551043,0.027823938,-0.024843257,0.009253077,0.0039550504,0.033830807,0.009165655,-0.056645557,0.011360049,0.083529495,-0.15873785,0.011013908,0.07721061,0.005348907,-0.040546596,0.02608808,0.06901187,-0.033887085,-0.009947566,0.010473314,0.009399459,-0.007108681,-0.07640909,0.03895558,0.058021262,-0.057337478,-0.0115982145,0.014490039,0.00183721,-0.018773826,0.011243183,-0.010059852,-0.100726426,-0.09682772,0.05592903,-0.033135507,-0.056248363,-0.060440402,0.018472293,0.09010841,-0.026730932,-0.0052386597,0.050562475,-0.023832405,0.090061456,0.0073213214,-0.0025091337,0.098787665,-0.02143682,-0.031285252,0.031495295,0.05502478,0.056627203,-0.0058457716,-0.004403211,0.008759504,-0.03413116,0.0007911427,-0.09911525,-0.0080785435,-0.0051456597,-0.07325827,0.023376929,-0.04834209,-0.01794531,-0.0032900728,0.032411747,-0.008884653,-0.08467038,-0.10350988,-0.032789946,0.060839936,0.024318526,-0.04479612,-0.03505192,-0.03695093,0.067062065,0.05136592,0.031738736,0.00977307,-0.007439961,-0.0007774803,0.0361736,-0.081683815,-0.0026738758,-0.004094512,-0.017851243,-0.012537455,0.04366772,-0.07978947,0.071923584,-0.03347533,-0.087061495,0.008091604,-0.011734748,-0.009989522,0.036821008,-0.027343227,0.034973316,-0.061916668,0.04594653,-0.019421916,-0.0045969947,-0.031744197,0.04332999,0.034053292,0.04401653,-0.028215675,-2.1462767e-33,0.11406432,-0.04266113,-0.037240766,-0.03736176,0.02645331,-0.08240913,-0.08214556,0.00472124,-0.091557205,0.030830942,-0.06105907,-0.04424688,0.016059704,0.08794716,0.014428623,-0.061159637,-0.026992785,0.002801455,-0.032838855,-0.042519547,0.014821333,0.083610296,-0.058313392,0.00086021895,0.008766056,0.021599183,0.0064030876,0.02065603,-0.016524076,0.01624538,0.011892832,-0.009170115,-0.041281294,0.037520375,0.068780385,0.036293183,-0.075915754,-0.033288956,-0.054987438,0.0064665857,0.023906944,0.046219446,-0.1530533,-0.03933306,0.07450548,-0.026297688,0.03898101,0.06428583,0.039396558,0.009680364,0.09171131,0.03827315,0.06391559,0.017542003,0.023516918,0.057335507,0.044454347,0.037054613,-0.0138944145,0.014294248,0.036823366,0.057927005,0.059645444,0.003835075,-0.010090586,0.012678942,-0.09749129,-0.029457388,0.053228043,-0.043729745,-0.07640945,-0.03425762,0.060641713,-0.010363624,0.10054764,-0.029398596,-0.021048838,-0.032663435,0.052523255,0.021305691,-0.03448475,-0.06942991,0.044818264,-0.07502611,-0.011491521,-0.008981306,0.0362018,-0.07987259,-0.043516345,0.022534514,0.029638775,-0.058763735,-0.0150340395,-0.055421896,-0.031624828,6.4240083e-35,0.054766104,-0.11092574,0.026051851,0.025963172,-0.05402346,0.07957957,-0.047915846,0.052368112,0.014440528,-0.056346532,0.06191763,0.05543709,-0.04177713,-0.0288058,0.102868475,0.034763902,0.084049046,0.06573464,0.0439612,0.027134405,-0.058273256,0.066288,0.0031204007,0.02982595,0.067351215,0.012074717,-0.0011892435,0.00461159,0.026027558,0.015048099,-0.060512736,0.033609483,-0.08236945,-0.03179135,-0.06444252,0.057614576,-0.03572162,0.039286386,-0.0532221,-0.009558516,-0.004803511,-0.015170885,0.103348024,0.070647314,0.019351395,-0.015539387,0.045754146,0.02744515,-0.09099224,0.034065396,-0.008381162,-0.008195442,-0.07174205,0.059938688,0.11400921,0.048623316,-0.038194317,-0.11578093,-0.05404402,-0.06892561,-0.01461468,-0.0037887394,0.006189063,-0.06785144,0.12961762,0.052935116,-0.050420936,-0.012452029,0.049159292,0.009112191,0.092796534,-0.018286297,-0.10544723,0.018873889,0.003146355,-0.08943454,0.031560525,-0.04353518,-0.018392375,-0.015107207,-0.12685093,0.029117174,0.014953081,-0.020250412,-0.0903263,-0.016506217,-0.0738796,-0.019414116,0.03947313,0.07329267,-0.043771796,0.0059337523,0.0807639,0.031188773,0.0316761,-1.9466597e-08,0.044730727,-0.004485126,0.08409653,0.011409004,0.06987466,0.012850274,0.025486551,0.04484547,-0.04179054,0.039458167,0.034082506,0.08701013,0.13622516,-0.027659465,0.11299997,-0.050426852,0.030812873,-0.0075785816,-0.07629879,-0.025150392,-0.07963536,-0.030050835,0.05359907,0.0073281797,-0.06491677,0.007762493,0.056382284,0.014657076,-0.024413928,-0.047266766,0.005121955,0.028599005,-0.05178525,-0.05229921,-0.03451259,0.024767773,0.041488975,-0.008215706,-0.020299194,0.06917414,0.025001947,-0.02669155,-0.011699408,0.05848959,0.016640224,0.017020812,-0.024881607,-0.04045137,0.016847055,-0.036632422,0.043290075,0.025383187,-0.10750492,0.012853201,-0.057587985,0.036898583,-0.01879057,-0.039202668,-0.00010779686,-0.017213738,0.04328914,-0.024978176,0.116196245,-0.06412467 +1.2.1.43,A tungsten-selenium-iron protein.,384,1.0,-0.020744322,-0.016516315,-0.055336483,0.1625135,0.07794846,-0.015662614,0.09394702,0.059965275,-0.008276666,-0.11050302,0.020766735,-0.04721034,-0.0008805687,-0.0019796991,-0.040888947,-0.0018881822,0.019853942,-0.049948975,-0.07748916,0.01884786,-0.008472861,-0.0006515229,0.07723559,-0.027417235,0.019100064,0.08575523,0.08570995,-0.02133406,-0.009199021,-0.044138793,-0.03203597,-0.09487507,0.04975318,-0.0033850386,0.043927595,-0.009168877,-0.0076713944,0.013428191,-0.023347368,-0.045516837,-0.009536858,-0.024028795,-0.0035034616,-0.024394358,-0.053603455,-0.029906226,0.043922663,0.011381244,0.057361692,0.16360499,-0.02308368,-0.06821322,-0.00993717,0.083779305,0.011929434,-0.057339247,-0.0024318076,0.04002655,-0.0049467874,0.006799118,0.015313773,-0.07801398,0.037845194,0.017990615,-0.0024105513,-0.026839977,0.025850097,-0.016338574,-0.024659315,-0.038537055,0.00617313,-0.01914471,2.120171e-06,0.04852268,-0.025939642,0.06261692,0.060613673,-0.056031916,0.13979867,0.07409206,-0.07460933,0.0694369,0.059438463,0.0945799,0.053650532,0.070701346,-0.00073712185,-0.041910563,-0.101256706,0.0008420524,-0.048132967,-0.00017000953,-0.028525343,-0.026092026,-0.04159338,0.080322064,0.060702488,0.04272546,-0.029983135,0.006993586,-0.03435722,0.052970074,0.03336916,-0.053732704,-0.06582808,-0.01817253,-0.13232906,0.103509836,0.03887337,-0.034580242,0.04611182,0.001274227,0.05456309,-0.04498101,0.034546733,0.037701234,0.049764168,0.023367511,-0.04578744,0.0019770921,0.04360559,0.043622497,-0.0054158117,0.0139842965,-0.01670455,-0.028084306,-0.023651775,-2.3016598e-33,0.062908694,0.017620264,0.01791532,0.04994934,-0.07935273,-0.043520432,-0.061043683,0.021404043,-0.06663761,-0.009712311,-0.106663115,-0.060368348,0.08807685,-0.06661595,0.0101669,-0.043721605,0.008877462,-0.022887219,0.05381157,-0.051262207,0.041965023,0.07451031,0.06433913,-0.0026291143,-0.04269746,0.021092918,-0.0035939564,-0.048538957,-0.030341577,-0.012048315,0.028097704,-0.019307317,-0.08561994,-0.04429265,0.046939958,0.013283704,-0.04521885,-0.027697785,-0.056735598,-0.029749634,0.06318207,0.05413556,-0.058040585,-0.051658753,0.059671562,-0.13481598,-0.010301489,0.10426818,0.028869746,0.024788959,-0.037766557,0.012985878,0.09331672,0.010046338,-0.045060538,0.016433807,0.060200017,0.0146737695,0.0011076019,0.04203293,0.012154173,0.008170749,-0.037641395,0.09471031,0.042586073,-0.026818788,-0.08241519,0.01125681,-0.039189767,0.0092114955,-0.012615637,0.039999142,0.025323402,-0.034661904,-0.021827154,-0.063491896,-0.08313054,-0.07470564,0.03306082,0.06046936,0.0048257164,-0.0018418062,0.0031845802,-0.084328614,-0.10525537,-0.019245578,-0.044043433,0.023397442,0.012713548,-0.042405713,0.04646286,-0.07331919,-0.08905379,-0.055623487,-0.093157634,1.3465661e-33,0.014024672,-0.08527382,0.036511697,0.055197,-0.023404088,0.0016538574,-0.018050397,-0.0036141663,-0.070366174,0.045312706,0.15645385,-0.042939465,0.04909312,-0.035187818,0.04354845,0.09336836,-0.014394517,0.030507239,0.09563133,0.00516085,0.03701264,0.020065933,-0.04429907,0.029087806,-0.03258507,0.03658143,0.0224367,-0.085399255,0.045470968,0.11729781,-0.00917061,0.026981818,0.02468442,-0.067159005,-0.03279131,-0.06242067,0.00012798115,-0.019241227,0.03745935,-0.011276919,0.017928386,0.026893785,0.030824978,0.13722195,0.10035192,0.020385217,-0.08508336,0.07541693,-0.021181332,0.033115745,0.013982387,-0.0631594,-0.06224989,-0.053173892,-0.023993464,-0.01835724,-0.047551405,-0.008911095,-0.053011563,0.011506954,-0.01438364,-0.006799787,0.0663721,0.08660175,0.010118522,0.08354748,-0.039395593,0.03396267,-0.025960537,-0.06910239,0.04559952,0.031068332,0.062459923,-0.039967164,0.080576666,-0.101022035,0.04110153,0.084568866,-0.024542622,0.040579814,-0.004803035,0.030053921,0.03447022,-0.03814792,0.08176624,-0.0150917815,-0.08228557,0.052152667,-0.011078914,-0.0019968597,-0.10045323,-0.024888797,-0.027585357,0.04375409,0.063155614,-1.7781725e-08,-0.041030765,-0.02605129,-0.019373192,-0.08158755,-0.035617027,0.0042233397,0.039178573,-0.06120496,0.007906579,-0.016985286,0.024414474,0.10059,-0.027990922,-0.047696196,0.013050486,-0.011473733,0.024753112,0.0101435715,-0.0026128583,-0.017561221,0.059780687,-0.038296815,0.08392771,0.013942764,0.0074972785,0.0012535279,-0.022784013,-0.006200903,0.029718122,-0.07175373,-0.04754662,0.024610378,0.012793029,-0.01056327,-0.04276583,-0.0057351086,-0.024797684,0.04196435,-0.05647117,0.0704598,-0.027886538,0.013007757,-0.029873088,-0.03196856,0.012769363,0.007249698,-0.06765628,0.031501934,-0.0062716487,-0.061908443,-0.004551242,-0.06515752,0.028452866,-0.010977598,-0.07134701,0.08803405,0.055866417,-0.070411496,0.00823358,0.0047665006,-0.04462772,-0.061976355,0.07085505,-0.0015493918 +1.2.1.44,Acts also on a number of substituted cinnamoyl esters of coenzyme A.,384,1.0000001,-0.047248926,-0.096632555,0.0013499687,-0.02019667,0.012251127,0.10604227,-0.034949876,0.006964008,0.043059386,-0.008646765,0.09423361,-0.059041068,-0.05299162,0.04367489,0.033432305,0.04629555,-0.071764976,-0.011505534,-0.02650895,-0.014136601,0.054151293,0.033464868,-0.023167672,0.020903047,0.026695238,-0.047569107,0.03517867,0.031144844,0.062145267,-0.041120626,-0.03705807,0.0012865801,-0.010540835,-0.0066172774,0.033628173,-0.007450014,-0.073514074,-0.07254103,0.09166522,-0.025321009,0.0527288,0.028469631,0.010373281,-0.016418904,-0.044166755,-0.030875614,0.021798134,0.03512742,0.0038771352,0.015517726,-0.033084787,-0.046512205,-0.040881854,0.031581473,0.0072575593,-0.00019270416,-0.076838136,-0.032171432,0.022290815,0.007884935,0.058461513,0.032452855,-0.011524308,0.02064559,-0.107649125,0.018571053,0.081756435,-0.010457936,0.0608651,-0.020480493,-0.10763245,-0.08887954,-0.056251206,-0.021978661,-0.02144439,-0.042452645,-0.045602243,-0.067198426,-0.036473237,-0.011411472,-0.021490442,-0.0738138,0.03982266,0.037634995,0.08593791,-0.02520325,-0.011973822,-0.050418448,0.08497393,0.01397359,0.03769896,-0.050994314,-0.0461883,0.013962665,-0.05795919,0.048574805,-0.03536452,0.033639763,0.020435998,0.04504455,0.014218001,0.0857433,-0.021352293,-0.066211365,-0.111827806,0.018801851,0.018499121,-0.00072584185,-0.050716612,0.05237452,-0.04381505,-0.024950456,0.052317306,-0.0719454,-0.021801054,0.028773615,0.030088808,-0.041092694,0.064353876,0.023802612,0.08923992,0.04498981,0.08216981,0.057489276,-0.050178878,0.015636537,-0.105459005,-3.3117613e-34,0.008708987,0.024782272,0.0063151866,0.08791413,0.0028659385,-0.03453334,-0.07588538,0.07969944,-0.09852447,-0.05215879,-0.034930196,-0.052430864,0.0466677,0.017819306,0.04800283,-0.037389133,0.07115756,-0.026951611,0.06877353,-0.0048804306,-0.012717999,0.07327808,-0.020077636,0.04068137,0.0026174088,-0.031134207,0.0062660226,0.10294511,-0.00028468957,0.0024580602,0.0039904607,-0.024155427,-0.05806351,0.035075232,0.082588494,0.07626556,-0.08110954,0.0057320506,-0.011032067,0.028850276,0.022330325,0.030615645,-0.037255716,-0.034692537,0.01709481,-0.036711063,-0.015317749,0.12370989,0.07673323,-0.0090215355,0.04820905,-0.01238438,0.021250363,0.018912,-0.020053534,0.050823838,-0.026688319,0.01238653,0.011896877,-0.007671511,-0.040617123,-0.011569609,-0.056559723,0.0017727652,-0.05934151,0.027690802,-0.12374391,0.021175895,0.018386057,0.02400729,-0.050089505,-0.014864182,0.008196868,0.021650104,0.07283122,-0.03715815,-0.08887979,-0.02688451,0.10539707,0.06482864,-0.0128084645,0.007788797,0.015624609,0.022715745,-0.068418555,-0.025147377,-0.022381548,-0.014440691,0.10425922,0.047555257,0.051061317,-0.048400983,-0.015085969,0.034292996,0.059610114,-2.1557635e-33,0.04075981,-0.04568539,0.027285574,-0.018046228,-0.013487941,0.009653196,0.051234663,-0.07656736,0.01703443,-0.042135227,0.095504984,-0.016431687,-0.043276723,-0.06136709,0.0067836475,0.04075001,0.034852766,0.05430635,0.024316585,-0.029240273,-0.021579886,0.048721984,0.04831677,-0.02828327,-0.027106589,0.046752427,3.768564e-05,0.088820815,0.06999212,0.082980715,-0.0457274,-0.08428273,-0.000603351,0.023848552,-0.030105684,0.0993825,-0.02493032,0.08130252,-0.017349372,0.002541806,0.016535034,0.018609526,0.048319206,0.10159487,0.055830672,-0.012243682,-0.026080767,-0.10489552,-0.07362593,-0.09996412,-0.027611298,-0.0062205247,-0.036768746,-0.03653187,0.012467233,0.093313135,0.03643738,-0.08548251,0.05250142,-0.036654577,-0.018130464,0.032047126,-0.0073984205,-0.050372887,0.05481103,-0.020480964,-0.080405384,0.012858066,0.07320894,-0.063313544,0.065973535,0.009281344,-0.02858478,-0.030649794,0.01959023,-0.11366679,-0.039867815,-0.034978546,-0.0742666,-0.045444187,-0.042503793,-0.06176124,-0.0063155144,-0.042319316,-0.12812941,-0.057406336,0.011545141,0.022505587,-0.014120093,0.024140418,-0.008369796,0.097415455,0.06306945,0.030423176,0.044672474,-2.284933e-08,-0.046672925,-0.04343718,0.044584867,-0.055396307,0.018631615,0.008947267,0.024241202,-0.04137942,0.016123015,0.059910636,-0.00090004207,0.062864155,0.08755691,0.051260382,-0.024455028,-0.00013915864,-0.049969714,-0.017779155,-0.044834826,0.024327867,-0.078204855,0.043243363,-0.044524547,-0.053045645,-0.056689035,-0.078328885,-0.035997972,0.05651944,-0.08897234,0.07797617,-0.021388534,0.011873386,0.015123901,-0.030731207,-0.088506676,0.049974613,0.09718407,-0.09399483,-0.07375903,0.023376927,0.055800572,-0.109391674,-0.07895001,0.059241366,0.15346107,-0.053756103,-0.033733916,-0.018493395,0.024666186,0.037135556,0.08424757,0.00627997,-0.06265237,0.07311204,-0.021041455,-0.05816784,-0.027599094,-0.018026,0.02517002,-0.06643349,0.021473289,-0.04641521,0.1058478,-0.061447833 +1.2.1.45,"The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity.",384,0.99999994,-0.052556463,-0.04225177,-0.045632392,0.005987787,0.048817918,0.052286852,-0.07745138,-0.0064862715,0.038262267,0.005798414,-0.020180685,0.05770791,-0.073880404,0.057311278,0.0032892285,0.03830809,0.013884027,-0.008282193,0.048940137,-0.01694447,-0.011985772,-0.04075535,0.037750557,-0.044398136,0.118660755,0.01863409,-0.006533858,0.013194489,0.003161497,-0.030209055,-0.03337115,0.021860095,-0.067098625,-0.06138787,-0.031164162,0.070188195,-0.07306701,-0.01566604,-0.027692853,-0.035896286,0.036196146,0.006537271,-0.13823809,0.024659095,-0.03898316,-0.08899782,-0.007980735,0.037556663,-0.014152372,0.018559994,-0.03792908,-0.023453854,-0.009394369,-0.0057836147,0.008399341,-0.0022399602,-0.014681296,0.025672365,-0.07173205,-0.08862372,-0.04521041,-0.059378773,-0.0002773917,0.043014888,0.04262106,-0.052706502,0.05414654,-0.010273235,-0.023874043,-0.02743669,-0.14335793,-0.052913822,0.041945692,0.04019891,0.03428803,-0.0077410573,-0.09155437,-0.03317542,0.075247705,0.01307414,0.04462328,0.026603129,-0.014508605,0.074341245,0.072830714,0.012387571,0.0012120362,0.032787297,-0.05435917,-0.0032980938,-0.011551148,-0.018816609,-0.035164807,0.041818835,-0.11184414,-0.02970923,0.0063413233,0.04308495,-0.040881366,-0.043918893,0.03413447,0.1012409,-0.04516869,-0.07137944,-0.05059285,0.0061769197,-0.024120513,0.06915108,-0.035918713,-0.01787551,0.012223402,0.012187171,0.06363236,-0.06796452,-0.052407276,0.11101777,-0.0014422315,-0.064160034,-0.10557237,-0.02330113,-0.027886773,-0.031831753,0.04361852,0.045230415,-0.02994162,0.06876428,-0.074427195,1.0401372e-33,0.04808408,-0.015851103,-0.03148558,-0.056019023,0.061168324,0.06487548,-0.06073787,0.072370835,-0.05092252,-0.016435532,-0.0044454136,-0.10182633,0.04598177,-0.010448842,0.032304335,0.030629346,-0.0054956367,-0.0766324,0.037958212,0.003506915,0.040155616,0.050218496,-0.046331394,0.065570116,0.008282292,0.060865425,-0.0803446,0.099564515,-0.0261185,-0.021097245,0.058465082,-0.058649655,-0.15465494,0.015634296,0.05611114,0.027907029,-0.02581428,-0.048397046,0.0016028259,0.006593416,-0.04337534,0.06862245,0.053986702,-0.04910005,0.01819282,-0.09409271,-0.008040678,0.071624994,0.04558959,0.038839348,0.0700172,-0.033814896,0.08900878,-0.052522395,-0.038821872,0.12685706,-0.037658583,0.030202586,-0.020519491,0.03716223,0.015254166,-0.03393364,-0.01202724,0.016807001,-0.060543094,0.041251324,-0.06233807,-0.032029767,0.0025122226,0.07849695,0.022055183,0.06228432,0.021226022,0.054552067,0.04786674,-0.04621865,-0.0008953903,0.033300973,0.07668277,0.042246033,0.019851185,-0.041898705,0.013081668,-0.03113562,-0.051317338,-0.008643608,0.020767363,-0.0039016628,0.022118349,0.042012896,0.05414413,-0.03331615,-0.0291573,-0.022139207,0.04625822,-3.783077e-33,0.068158515,-0.051981464,0.042914443,-0.09530621,-0.025636138,0.08159575,0.05042561,-0.13241802,0.009890117,-0.045328107,0.09130058,0.03442552,-0.009819212,0.014529957,0.025147203,-0.003703528,-0.120767854,0.03406974,-0.0005179454,-0.0029625564,-0.03427832,0.09809755,0.028156178,-0.02650668,0.069070764,-0.042631842,-0.039172832,0.06642264,0.070107676,0.01625855,0.008862214,0.01539938,-0.11465426,-0.029706795,0.028662767,0.040159855,-0.06512773,0.01149969,-0.05998138,0.035087906,0.045419004,0.028231118,-0.038307253,0.0511715,0.10120618,0.010410255,-0.10875726,-0.02788246,0.0078040124,-0.11504945,0.023362387,0.08248918,-0.04433595,0.03924883,0.07460709,0.06287978,0.007753584,-0.0073517105,0.05619035,-0.048816793,-0.05011832,-0.052088656,0.009601347,-0.0391548,0.05125453,0.010690365,0.01533956,0.016933871,0.070548035,-0.060114153,0.08033657,0.005572616,-0.018196242,0.022658637,-0.025502108,-0.020565381,-0.062355667,0.03534636,-0.03755241,-0.07696082,0.013384857,0.0033096983,-0.0475327,-0.06622533,-0.01073255,0.031825714,-0.018902425,0.045564234,-0.05879728,0.04258366,0.006740597,0.07200567,0.0027888792,-0.011155527,-0.0030732783,-2.9652716e-08,0.024925461,0.011705755,0.039113577,-0.057601716,0.0069378656,0.0018836941,0.0049284194,-0.079600476,-0.01553964,0.029274268,-0.04331734,0.1052968,0.03013227,0.052512724,0.023146959,-0.044906285,-0.010526898,0.009923724,-0.020587258,-0.022980329,-0.10863011,0.06049341,-0.14964406,0.08351811,0.023881895,-0.019404016,0.004596256,-0.05492334,0.073305845,-0.059899017,0.008565367,0.07769597,0.068040974,-0.015983695,-0.055031084,0.024339167,-0.0036774566,0.031491224,-0.06170009,0.051324934,0.0045741266,-0.08913982,-0.021598067,0.010664278,0.010931887,0.019876473,0.08367467,-0.09350174,-0.044790827,0.028163021,0.10392991,-0.013789651,0.013987736,-0.077748984,-0.042762,-0.0006940688,-0.0035182321,-0.047808193,0.010336178,-0.055062074,0.020388324,-0.081988215,0.091862,-0.057361946 +1.2.1.81,The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.,384,1.0,-0.0166182,-0.018454717,-0.024800966,0.009660441,0.02148719,0.04506146,-0.08499497,0.017458785,0.018688766,-0.012192683,-0.006027274,0.073901646,-0.059858784,0.018445851,-0.0949935,0.079793096,-0.07121712,0.030768733,-0.015033718,-0.052898638,0.029277876,-0.032106988,-0.04191225,-0.019689374,0.05254642,0.076011814,0.005328048,0.00037068222,-0.05452061,-0.023034517,0.008693813,0.03648313,-0.026392603,-0.061609898,-0.03698064,0.08801916,-0.06462302,-0.0551051,0.01753031,-0.011547945,-0.012789906,0.036305092,-0.13605496,-0.044307396,0.008586134,-0.044794217,-0.07338349,0.04962111,0.011286665,-0.040227816,-0.025681308,0.009383095,-0.045912474,0.02945809,0.013315781,0.0032847456,0.027318407,-0.004107567,-0.044446975,-0.031347185,0.02193751,-0.033408586,-0.063144945,-0.014317116,0.09581956,-0.068318225,0.08194258,-0.0460461,-0.013650047,-0.021915298,-0.13615775,-0.058503527,-0.028277552,-0.0064166323,0.026225166,0.002821149,-0.047501393,-0.008049435,0.097011134,-0.025334083,0.089392535,0.03349511,0.01745736,0.08212322,0.07045775,-0.007131213,0.0066444445,-0.061236333,0.07145651,0.041610263,-0.014686909,-0.03073193,-0.0407109,-0.024850871,-0.039801985,0.018629616,-0.003091863,0.08533346,0.037859347,-0.014878883,0.028077483,0.017449563,-0.0634842,-0.09632402,-0.046535064,0.038864754,-0.02539041,0.10116504,0.022880813,0.029869672,-0.031925306,0.006658061,0.06849387,-0.0050683864,-0.004568756,0.1465887,0.03510891,0.027632331,-0.08756398,-0.027345428,-0.0137313325,-0.0025696058,0.016711866,0.02900322,-0.01067091,0.03291713,-0.10926524,5.2678115e-35,0.09627842,0.016879518,0.035245027,-0.030123299,-0.007192649,-0.016670126,-0.07979427,0.06850338,-0.018647606,-0.016886806,0.00940295,-0.07368143,0.009433013,-0.024619646,-0.018862842,-0.0012661736,-0.018247258,0.0032226504,0.014392441,-0.03516989,-0.016682433,0.036720842,-0.036677334,-0.02800916,0.040983237,0.050642233,-0.019108675,0.062123366,-0.10396415,-0.01636167,0.08057941,-0.09294871,-0.119251356,-0.021602008,0.07461087,-0.007355313,0.0026478646,-0.055563234,0.00016133711,0.04502335,-0.012861665,0.0038478794,0.022683516,-0.041357152,0.014734938,-0.07147233,-0.031261988,0.10555048,0.06854373,0.06465807,0.021134518,-0.044553675,0.0922363,-0.034407984,-0.05245997,0.05759508,0.017800074,-0.03658628,0.020858264,0.038666386,0.026532998,-0.002354907,-0.03844278,0.00077997136,-0.014813428,0.024028184,-0.058218647,0.01644032,0.035657376,0.064308226,-0.09353236,0.0071857446,0.0015677247,0.05210545,-0.0012729723,-0.048851486,-0.05602555,0.037724722,0.058360416,-0.026683252,-0.097957596,-0.040736236,-0.045577705,-0.028825331,-0.07459018,-0.0072713424,0.0064195874,-0.076575145,-0.02976445,0.024943048,0.02602985,-0.01579464,-0.062900014,0.038695782,0.10928728,-3.2730362e-33,0.072554745,-0.047254864,-0.007668132,-0.12216985,-0.09403769,0.02947117,0.041146632,-0.011996301,0.03654273,-0.012145297,-0.016520686,0.020907464,0.0735496,-0.010073243,0.005559688,0.060444545,0.014321955,0.031878974,-0.019920396,-0.01721453,-0.002275159,0.12146284,-0.0066750715,0.014479473,0.025950776,-0.026126519,0.052657638,0.04802765,0.11955779,0.01910409,0.010216275,-0.019788945,-0.028381402,-0.015911344,-0.0083333645,0.037297316,-0.055501416,-0.018442476,-0.0005592282,0.00086719677,0.013793963,0.010422635,0.019987136,0.10634475,0.05066417,0.032768365,-0.12619916,0.022163771,0.033625413,-0.106952794,0.09387091,0.05719733,0.00413012,0.067081116,0.01014141,0.0699285,-0.004846544,-0.0524936,-0.02610858,0.010563966,-0.068623915,0.0005769888,0.062547036,-0.035688713,-0.023668472,0.040915605,-0.041386575,-0.039058562,0.05026339,-0.057933256,0.07415357,0.023175582,-0.027702264,0.017502615,-0.05826745,-0.0822908,-0.0952414,0.08059928,0.0022580628,0.019390574,0.012567022,0.025970533,-0.0038231816,-0.061497573,-0.065979585,-0.093421385,-0.033729292,0.1316816,0.0064549604,-0.0073327045,0.002735047,-0.02838864,-0.083444364,0.017732969,0.021758609,-2.8370449e-08,-0.028638856,-0.06830463,0.084147945,0.00058303686,-0.019304838,0.053603087,0.09347679,0.01854831,0.006965749,0.013312929,-0.04222474,0.13948062,0.00032893027,0.022221664,0.042050377,0.011559163,-0.05496963,-0.011525816,-0.038064018,-0.036791638,-0.036813386,-0.0634667,-0.07347187,0.106457025,0.08926728,-0.049676437,0.028293034,-0.0030927828,-0.02986816,-0.019623753,0.030072143,0.06312912,0.012230812,-0.029935459,-0.029336013,0.08688882,-0.0028293515,-0.050839458,0.024564886,0.02275647,-0.03426052,0.0013664246,-0.082168214,0.003749059,0.022533575,0.034385983,0.053286664,0.009248713,-0.057214227,0.036325548,0.07369492,-0.020715762,-0.034000102,-0.05509889,-0.09138064,0.020198254,0.039466362,-0.074014,0.019316504,-0.011951441,0.043769762,0.0044519114,0.19591373,-0.061357908 +1.2.1.48,The best substrate is dodecylaldehyde.,384,0.99999994,-0.03682068,-0.064892694,-0.0060648117,-0.08064169,0.0020642243,-0.02452922,-0.002492719,0.057396185,-0.053553887,-0.036106348,0.014809358,-0.07823035,-0.10103544,0.1080987,-0.009717392,0.009482185,0.03640427,0.035678785,0.083487,-3.4783978e-05,0.035728123,-0.022948215,0.020816613,-0.010956869,0.025221756,-0.002989493,0.0039079566,-0.026401186,0.017320434,-0.13491109,0.02310901,0.021426082,0.00065014133,-0.06282521,0.039548483,0.047456518,-0.051265117,-0.05755486,0.039708976,0.0036868125,0.0091820955,-0.002495453,0.056020353,-0.040073957,-0.04152658,-0.010585572,0.06565747,0.017678192,0.048092946,0.0044323015,0.0034015074,-0.038082313,-0.0163438,0.0050326567,-0.0015941007,-0.028919723,-0.033733122,0.016906586,-0.04740619,0.029311964,0.014895971,0.035602447,-0.02573241,-0.018241694,-0.051283948,0.037869938,-0.0032463507,0.009620334,0.041458227,0.022731168,-0.07365118,-0.060220204,-0.02857678,0.054768845,0.022369428,0.048277553,0.06338485,-0.12503925,0.069517456,0.014188764,-0.055963058,0.098923855,-0.0014836199,0.076150455,0.10320691,0.0058501842,0.0035330441,0.027924208,0.008739666,-0.009467114,0.027797576,0.124026604,-0.08144703,0.031703297,-0.06290505,0.07310874,0.047353897,-0.01950194,0.009090926,0.024705637,0.0026104602,-0.028832313,-0.055199735,-0.062099315,-0.06253319,-0.0041556954,-0.007716503,0.04480421,-0.00820864,-0.039466534,-0.00811398,0.050635472,-0.021208607,0.010483299,-0.054876175,0.033659387,0.051631253,-0.03949233,0.007292146,0.016698137,-0.04475884,-0.003341211,0.0561797,0.081674136,-0.032818377,0.008462367,-0.0010129444,-2.2010282e-34,0.025601365,0.05851987,0.002960394,-0.060313687,-0.03607902,-0.015390424,-0.059019156,0.025232265,-0.009812809,-0.0828955,-0.09309061,-0.0930635,-0.088694006,0.06865026,0.03856862,-0.120619856,-0.046468798,0.036839053,-0.008670541,0.013939051,-0.01597415,0.043218,-0.008940869,-0.07831197,0.0960241,-0.07558094,0.010615101,-0.003907734,-0.0046045478,-0.0007019142,0.009540602,-0.08604004,-0.0013064825,-0.01438083,-0.018853787,0.04416889,-0.1349385,-0.024564989,-0.041362755,0.048320677,0.053557597,0.06776475,0.09083721,-0.026215153,0.08004042,-0.045285523,-0.012900818,0.06279531,-0.036040984,-0.035059966,0.042916346,0.0022808742,0.055183895,-0.0027491613,-0.06434903,0.013822021,-0.006060482,-0.04724707,0.019826507,0.08052353,-0.090910204,0.06417049,-0.042080868,-0.008731712,-0.0025244285,0.0144304065,-0.03666252,-0.007076877,-0.091679476,-0.022589171,-0.025065772,-0.031128192,0.077279665,0.014408602,-0.042903356,0.0063662794,-0.0060653435,0.02544237,0.063678324,-0.0038972537,0.017446643,-0.02475932,-0.040498655,-0.07269906,-0.11996746,-0.0076273466,0.008541521,-0.0032710067,0.028968073,0.05196298,-0.01368747,-0.07657692,0.07486361,-0.011532615,-0.02883662,-6.834953e-34,0.121756315,-0.13266043,0.124233715,0.000727064,-0.049375102,0.029095894,0.07204318,0.01483614,0.016753636,0.02896921,-0.026208716,0.039499596,0.06325211,-0.04775601,-0.0096319895,0.04773218,0.024283808,0.033334102,0.057931814,-0.019338991,-0.03520553,0.14702013,0.021752702,0.074213415,0.042908516,-0.0072188135,-0.010587842,0.026518974,0.01826632,0.030939268,-0.058271196,-0.04483798,0.026463699,-0.053073518,0.0067668464,0.031380907,0.00089373294,-0.050711032,-0.02425923,0.034687467,0.040440228,0.026318116,-0.012223472,0.08068685,-0.04834517,0.056322455,-0.1393945,0.008606488,0.032698546,0.0011360997,-0.0019968075,-0.020903645,-0.024022877,-0.04568152,0.022827538,0.029005544,0.03438689,0.0053775334,-0.012576594,0.013867219,-0.06977565,-0.021692812,-0.0053515173,-0.08202662,0.047046952,0.09399464,-0.04234031,0.06307409,-0.030684968,0.008664005,0.10140436,0.07780946,0.021462796,0.051986396,-0.03109035,-0.06887506,-0.0016450887,-0.0028634116,0.016941056,0.0470966,0.07850846,-0.013053877,-0.046420313,-0.008709682,0.04745371,-0.014959415,0.023131602,-0.012707158,-0.011461813,0.048012104,-0.000496785,-0.027498573,-0.022926504,0.065263726,0.06054277,-2.0057014e-08,0.09029001,-0.039333582,0.040060382,-0.072064154,-0.11229439,0.01378482,0.039589282,-0.0505774,0.013885272,-0.12967014,-0.046864532,0.06226335,0.018224059,0.03843521,0.053760264,-0.02252145,-0.040952474,-0.002557491,-0.0539272,-0.029419914,-0.09213646,0.045831993,-0.029132368,0.026270553,-0.049799275,-0.029698005,0.097950205,0.022952642,0.06239526,-0.036064126,-0.023781197,0.0134592075,-0.04878659,0.041093256,0.08310002,0.10609194,-0.06497947,-0.061058596,-0.045153156,0.10801208,-0.016480267,-0.027924584,0.013796108,-0.054325476,0.04994688,-0.046192378,-0.0026978354,0.01590511,-0.030684514,0.04593265,0.084191024,-0.033135217,-0.022300867,-0.037786715,-0.07427942,0.00036112513,-0.048717167,-0.06549174,-0.025462322,-0.041240897,0.060950506,-0.0028071168,0.2011013,0.07419557 +1.2.1.49,Not identical with EC 1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+).,384,0.99999994,-0.097063355,0.0050974153,-0.01193663,-0.04310409,0.04532098,-0.03387854,-0.10099914,0.035274725,0.042911854,-0.04369095,0.0646598,-0.07039926,-0.071038246,-0.02879914,-0.04059239,-0.03321452,-0.0382039,-0.068381265,0.036024403,-0.02315508,-0.00039672703,0.050975293,0.016794717,-0.006994249,0.08681257,0.045223285,-0.025082404,0.072435334,-0.023796827,-0.087955356,0.06549108,-0.027664099,0.016769947,-0.02787756,-0.016692962,0.0070554106,-0.019682983,-0.035045296,0.025509393,0.064699925,0.024119383,0.022680847,-0.030690445,0.009743623,-0.039096154,-0.064003855,-0.019672723,0.046716314,-0.040231604,0.057667684,-0.0046842946,-0.053006656,-0.008130665,-0.0063831275,0.07991823,-0.01615195,-0.039257366,0.028068935,-0.05807512,-0.0142032495,0.015458068,-0.0426557,0.031409394,0.03370186,0.009069282,-0.0468657,0.100943655,-0.14405465,-0.00034474768,-0.06262034,-0.0935438,-0.018431783,0.029153164,0.0609407,-0.044144195,0.107004076,-0.080114275,-0.031217584,0.023925737,-0.052018356,0.023978842,-0.008604201,-0.059686966,0.014364235,0.02320874,-0.02646787,0.07373713,-0.019685216,-0.00617981,-0.005614882,0.024444385,0.0017029326,0.0011497779,0.09191824,-0.06833944,0.026927922,0.06907439,0.16616455,-0.032501925,-0.051742096,-0.020432632,0.14989634,-0.06153655,-0.01715708,-0.009212501,0.002680118,-0.010687903,0.07462194,-0.046055987,-0.01724273,0.038159776,-0.05653436,0.04593023,0.022093339,-0.0047812755,0.07451507,-0.016054291,0.007784154,-0.01927892,-0.021162007,0.059536528,-0.050853185,0.03167117,0.037374314,-0.034932896,0.016929463,-0.10604529,-1.0982313e-34,0.06599508,0.008596787,0.01309588,0.0035987361,0.021091504,0.021612996,-0.11675797,0.07866949,-0.05623332,-0.0035910155,-0.08772076,-0.027983097,0.066878736,-0.025404748,-0.043298922,-0.014659361,-0.03577039,-0.040928937,-0.021535615,0.026209265,0.0471575,0.07128146,-0.044003736,-0.013119976,0.029247342,-0.0029899369,-0.024219224,-0.021037417,0.027651241,0.011938143,0.012670839,-0.15256992,-0.058176037,0.014443597,-0.0031382614,-0.031843755,-0.010964225,-0.041299555,-0.013180108,0.017978314,-0.049037084,0.06510276,0.048783086,-0.10502796,0.03787502,-0.09250333,-0.0013048926,0.063720345,0.036948796,0.04446865,-0.042608872,0.0025331804,0.08053662,-0.053897314,-0.017585868,0.0026879995,-0.036211427,0.06588609,0.017652761,0.12555946,0.036733866,0.11966072,-0.0079344725,0.0037934242,-0.01953892,0.0017974931,-0.062040824,-0.06403503,0.027581308,0.06490877,0.014328208,0.040506914,0.10110669,-0.03197149,0.04761717,-0.038349036,-0.030020444,0.040993124,-0.009367536,0.010114459,-0.062782444,0.032408472,0.0086653065,-0.05264432,-0.03462901,0.057790082,0.003133678,0.034545504,-0.0022624554,0.0991166,0.049284037,-0.035508264,-0.03411783,-0.08840806,0.04637785,-9.393289e-34,0.015133447,0.0035182112,0.0012928179,-0.09168485,-0.034355737,0.13144717,0.036768783,0.024322137,-0.018653214,-0.029070918,0.13994844,0.07060508,-0.027808573,-0.0829277,0.08708825,-0.054802354,-0.07204624,0.023811307,0.012604301,0.04447013,0.045701806,0.113331616,-0.0022982669,0.014696016,0.050672613,0.024832867,-0.00856651,0.05664737,0.05797569,-0.035303473,-0.045042332,0.033309463,-0.06292247,-0.00896776,-0.008656411,0.03582094,-0.05762197,-0.04017476,0.013556587,0.04388676,-0.044673733,-0.030519318,-0.053581472,0.02725286,0.09296449,0.05485929,-0.06578979,-0.017199172,0.06276792,-0.063927345,-0.018868417,0.052615117,-0.07190808,0.023732662,0.065782644,0.0042517926,-0.023986649,0.07766183,0.024025299,-0.0023753738,0.023998467,-0.018573476,0.042675342,-0.024493095,-0.025381692,0.025348164,-0.025529068,0.031072892,0.04335606,0.0034201052,0.03764943,-0.03783093,-0.045323674,-0.031953022,0.023194307,-0.0862959,-0.04177711,0.0399148,-0.02707394,-0.032243475,0.008698834,0.010596544,0.009954733,-0.038166873,0.040108055,0.010104897,-0.0040124366,0.052086886,-0.06260192,0.049345925,-0.023177918,0.03598837,-0.13615711,0.048188165,0.013552654,-2.4155437e-08,0.06565073,-0.049633767,0.05461262,-0.007366403,0.053182382,0.009799142,-0.026757635,0.001430555,0.005110626,0.022805324,0.031002825,0.07845925,0.05987497,0.026688727,0.01098582,-0.03330611,-0.072110154,0.012042758,-0.008025245,0.022787169,-0.050215412,0.032337114,-0.12132025,0.010623306,-0.015727209,-0.019166185,-0.0011553917,-0.055710208,0.03476609,-0.059579853,0.047634147,0.015012902,0.069666035,-0.06765776,-0.010670827,-0.026211815,-0.04207408,0.05975779,-0.06202576,0.04078543,-0.00342559,-0.13013007,-0.028043782,0.045712423,0.09676529,0.04001306,0.06622786,-0.04717677,-0.073174566,-0.045554843,0.04857769,-0.0030679516,0.054257546,-0.040387854,-0.071189605,-0.014698529,-0.07277789,-0.09567301,0.006562175,-0.014474641,0.03913499,-0.07080702,0.124715224,0.02375337 +1.2.1.50,"Together with a hydrolase component (EC 3.1.2.2 and EC 3.1.2.14) and a synthetase component (EC 6.2.1.19), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme is acylated by receiving an acyl group from EC 6.2.1.19, and catalyses the reduction of the acyl group, releasing the aldehyde product. The enzyme is also able to accept the acyl group from a long-chain acyl-CoA.",384,1.0,-0.076971486,-0.036446374,-0.11679761,0.041227005,0.07918356,0.037414897,-0.11809883,-0.03493195,-0.00070524577,-0.084541775,0.027117554,-0.103238076,-0.040771,0.020736149,-0.0286305,-0.025799789,-0.101313345,0.0049861497,-0.017477246,-0.0634944,0.041265544,0.033576973,-0.057875317,0.0024712547,0.012929099,-0.02938659,0.025518574,-0.014566939,-0.035286374,-0.09518295,0.040762298,-0.05257433,0.04774956,-0.029841425,0.04451596,0.01824626,0.0069431267,-0.03557238,0.06251751,0.042823747,-0.002788506,-0.042846598,0.03127158,-0.0018281934,-0.043428537,-0.0044399025,-0.0052483897,0.024486749,0.07577137,-0.051319357,-0.045724276,-0.021212373,-0.035110552,0.108458094,-0.0135403825,-0.0019194141,-0.044288803,-0.07007943,-0.057659093,0.022344062,0.060083628,0.025615431,-0.04626085,0.037239477,0.0020698605,-0.053842895,0.025877185,-0.0990016,-0.021398224,-0.030891364,-0.08613519,-0.09654294,-0.063968845,0.032102626,0.041736294,0.0073390338,-0.013327849,-0.04337307,0.032971095,0.025278943,0.032404605,0.029070418,0.04919226,0.08041337,0.00060889777,-0.044443868,0.02814969,0.042367443,-0.008286408,0.07276769,0.0090438975,-0.053779457,-0.06760029,-0.014754106,-0.07017296,0.044578206,0.0069107357,0.028702853,0.058456223,-0.008369241,-0.07073265,0.011014076,0.00014791731,-0.051490646,-0.073144615,0.011984349,-0.006628979,0.13798177,0.009413744,0.03442781,0.06521598,0.015465525,0.012784072,-0.02099193,-0.0094524305,0.08298986,-0.007938497,-0.050669234,-0.09255459,0.03597147,0.04059283,0.027102798,0.117570885,0.088075615,-0.017956344,-0.018974118,-0.1379816,1.4736288e-34,-0.010724052,0.0487974,-0.043009162,-0.033794455,0.04160886,-0.031361055,-0.091828205,0.08471371,-0.04908257,-0.007936968,0.030656215,-0.028263379,0.047158554,0.05772668,-0.0045404523,-0.044740718,0.01216506,-0.005301928,-0.0048453766,0.0134639405,0.039378777,0.028987523,0.06558662,0.008606472,0.023187792,0.013085694,-0.022936048,0.063169174,0.003970419,0.013963923,-0.029900078,-0.08714262,-0.04917219,0.017705046,0.05123487,-0.011064275,-0.047645096,-0.059358634,0.040094193,0.013897287,0.1012209,0.042013615,0.02846191,-0.022200689,0.043796815,-0.034764584,-0.11069552,0.13404472,0.02863872,0.11481597,0.036382895,0.0005779679,0.066207916,-0.028088136,-0.06967015,0.057079926,-0.04446504,0.026312863,0.01168628,-0.03179974,0.011186016,0.09465796,-0.057995033,0.01886723,-0.060966134,0.021275934,0.013262237,-0.012712087,0.0042755557,0.050882567,-0.05673363,0.043026898,0.06520607,0.032346856,0.024818629,-0.079792455,-0.0702553,-0.039065357,0.028914306,-0.03029954,-0.027574899,0.031412564,0.083411545,-0.033284683,-0.010210347,-0.07881425,-0.08849171,0.02666183,-0.0028623703,-0.0046258746,-0.011609802,-0.06185044,-0.01651268,0.022112302,0.014458324,-2.219283e-33,0.15301584,-0.15649465,0.042716175,-0.13830534,-0.021718683,0.019038115,0.016767176,0.04411554,-0.016646054,0.008482139,0.054948468,0.055635907,-0.011039886,-0.025902722,0.044831026,-0.03679857,0.02724442,0.057783097,0.0027875614,-0.051167414,0.014326864,0.040076245,0.027417172,0.052624963,-0.011616875,-0.01820432,0.0245661,0.09338395,0.030211575,0.03537523,-0.02158326,-0.027187288,-0.0071030566,-0.08265125,-0.02595567,0.079272576,-0.068682864,0.018285656,0.010997779,0.051069204,0.09026858,0.021215323,-0.04372702,-0.033546846,0.057027977,0.07068654,-0.021019839,0.042662863,0.032261163,-0.1166543,0.044265494,-0.03080838,0.0069496306,0.02610966,-0.06211957,0.0426213,0.032952044,0.008373735,0.04257177,-0.06793479,-0.026510887,-0.08891509,0.034044623,0.0143452985,0.04341892,0.020205373,0.016540116,0.015485181,0.05508546,0.067176335,0.06411776,-0.006219645,-0.019870797,0.075111255,-0.00917331,-0.060889214,-0.011405356,-0.060365334,0.024156325,-0.02043263,0.018352425,-0.024489587,-0.019339548,-0.01680578,0.034447692,-0.047421556,0.029850254,0.0804306,-0.034067024,0.008058035,0.0029357867,0.04010943,0.014742288,0.005998562,0.065779656,-4.2142144e-08,0.074547976,-0.06051981,0.049661946,-0.005380239,0.060319576,0.055676956,-0.013365606,-0.02933884,0.023436937,-0.04236652,-0.029697418,0.05293201,0.039208867,0.027606433,-0.014407548,0.0074892123,-0.07079411,0.058648065,-0.031155793,-0.047527585,-0.042255662,0.02329605,-0.053539693,0.025765741,-0.029082265,-0.04489974,-0.0335957,0.019391391,-0.02947636,-0.0016125718,-0.0057284073,0.069515854,-0.01718926,0.008095953,-0.08648921,-0.043357275,-0.016134815,-0.049617246,-0.0056348746,0.021144863,0.091504246,-0.0029057995,-0.052250635,-0.021814866,0.04926211,0.0017237862,-0.044215996,-0.012055481,-0.030101342,0.040929012,0.08440359,0.028192809,-0.05769841,-0.01148367,-0.116366886,-0.052655764,-0.07103535,-0.11178489,-0.0038959007,-0.05695752,0.08583308,-0.0009985889,0.20387213,0.0032073082 +1.2.1.51,"The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen.",384,0.99999994,-0.041677013,0.023964368,-0.06600435,-0.026614835,0.0036388023,-0.022607408,-0.06346502,0.027484477,0.0014122248,0.0048493003,0.038749073,-0.015680829,-0.116724424,0.01831385,-0.002453432,0.054042477,-0.041255977,-0.007001189,-0.042250797,-0.023965323,0.055924635,0.028916856,0.007642087,-0.01978701,-0.063359484,-0.02952225,0.026106367,0.018763205,0.05250555,-0.06650667,-0.024269193,-0.015763713,0.044441458,0.01652803,-0.069621354,-0.03102485,-0.06234012,-0.053616628,-0.037601817,0.017909918,0.06521796,0.02701996,-0.042263877,-0.009366096,-0.053594165,-0.05030562,-0.011164021,-0.042611886,-0.02215019,0.027366458,0.008604843,-0.06470236,-0.04845755,-0.051279873,-0.032663435,0.03808631,-0.059056126,-0.06852115,0.014926356,-0.020561041,0.023488188,-0.0020604443,-0.0016651752,-0.024701543,0.06270158,-0.03196984,0.020582084,-0.031271394,-0.017506419,-0.055330697,0.0050614374,-0.104022615,-0.03977864,0.06980298,0.015069167,0.024593767,-0.010070549,-0.07921032,0.08668875,-0.00891762,-0.0021472538,-0.039562017,0.029429764,0.04702267,0.057562992,0.058194704,-0.004410593,0.03172404,0.0025808075,0.047343962,0.11290128,0.007849651,-0.031637125,0.030133963,0.014964827,0.038899146,0.07950545,0.03061239,-0.015401991,-0.038110875,0.00033958897,0.04263103,-0.05788727,-0.026061937,-0.058713507,-0.063000344,0.11126856,0.04940549,-0.021459352,-0.0013557523,-0.028839368,-0.04166101,0.07109214,-0.062457014,-0.044810142,0.075031206,0.0006940413,-0.07586279,0.07498717,-0.05328733,0.0032590237,0.006065401,0.089786634,0.07328694,0.009395778,0.036809906,-0.06598842,4.6616534e-34,-0.02833335,-0.028493153,-0.068250425,-0.0094659235,-0.01151394,0.04918897,-0.078171,-0.027664708,-0.0009647214,-0.119998716,-0.10241803,-0.02007936,0.035894215,0.049587946,-0.023987005,-0.04581651,0.022886513,-0.040816136,0.0076210187,-0.026784612,0.14376938,-0.0073430026,0.007020635,0.031802077,-0.033068232,-0.006684304,-0.05632459,0.07111557,0.066710874,0.003364412,0.01874178,-0.12137177,-0.085164644,0.020839753,-0.0025183633,0.114395425,-0.019406773,-0.00283633,-0.06492438,0.029076537,0.04017173,0.011599321,-0.01948676,0.020750405,0.082078256,-0.08991986,-0.1048501,0.10407131,-0.0323328,0.03850744,0.057726588,0.022855708,0.018212207,-0.018353447,-0.068713285,0.08230944,0.053731874,-0.024951562,0.041579593,0.0011094436,-0.030558651,0.04566791,0.011463764,0.11084206,0.03447962,0.04389132,-0.028284566,-0.03627505,-0.09117299,0.058079492,-0.036321953,-0.024247019,0.08130636,-0.028973034,-0.002556932,-0.0914809,-0.030356225,0.00345994,-0.08426062,-0.016625399,0.011612963,-0.008256142,0.004524308,0.00924332,0.001339152,-0.035445865,-0.013284549,0.0160408,0.05692898,0.04576055,0.102040015,-0.025074737,-0.03408109,-0.0030199888,0.081959486,-1.994566e-33,0.07473235,-0.060490463,0.08405109,0.0045040627,0.05643212,0.12803265,0.06764584,-0.06389319,0.0809201,-0.08583836,0.074017964,0.0076121856,0.0042744004,-0.039520014,0.05121227,0.07059691,-0.032743976,0.07903992,-0.0014633895,-0.011677221,-0.07246567,0.057768207,0.01263519,0.07829355,0.022570338,-0.02593535,0.004510895,0.018662231,-0.03139929,1.5388934e-05,-0.011216947,0.037053984,-0.016981084,-0.028112981,-0.07209234,0.00958777,-0.011654929,-0.025690513,-0.0036847193,0.0042716158,0.017427472,-0.0042092153,-0.04543473,0.059484493,-0.013446547,0.10130356,-0.04432009,-0.042177495,-0.05172709,-0.014197341,0.07896603,0.001774791,-0.023700362,0.007818153,0.09508239,0.03660996,0.07980237,-0.030747902,-0.019963156,0.027324691,-0.012012842,-0.054168325,0.07900629,-0.019784577,0.03422508,-0.0013808097,-0.013496628,0.10615618,0.024717616,-0.020253504,0.10880596,0.08535176,-0.040545136,0.041118212,0.004637405,0.030841626,-0.0175995,0.04215791,-0.0005026472,-0.045349043,-0.055813055,0.025719356,0.008971776,-0.030303566,-0.07354998,-0.0428367,-0.028061582,0.06046899,-0.01808114,0.036681652,-0.042197734,-0.070469566,0.017475806,0.028098946,0.08145242,-2.658387e-08,-0.037165005,-0.070724666,0.056710083,-0.036257714,-0.012048994,0.057258394,-0.017467182,0.028232219,0.06058137,-0.036678974,-0.014055056,0.06855776,-0.037902586,0.043001518,0.028685262,0.014369434,-0.052644875,0.06839931,-0.032990806,0.0016288143,-0.114473335,0.0730316,-0.03300345,0.010408453,-0.00010772005,0.008595073,-0.009116927,0.027347794,0.011622917,-0.09541509,-0.033541303,0.0072343335,0.016262881,-0.039291956,-0.15049513,0.053997006,0.13075209,-0.03645582,-0.07024578,0.07869566,0.037192743,-0.10422835,-0.052139368,-0.082975656,-0.034435365,0.02406814,0.032009277,-0.0025284453,-0.04440162,-0.01190628,0.026488654,-0.008534196,0.010949562,-0.028245408,-0.103286505,-0.012340128,-0.047682226,-0.07380187,-0.005708727,-0.05562674,0.04282617,-7.3596064e-05,0.1930184,0.0065554804 +1.2.1.52,"The Euglena enzyme can also use NAD+ as acceptor, but more slowly.",384,1.0,-0.08614699,0.017358538,-0.09492103,-0.013206276,-0.046315677,-0.007262212,-0.070469886,0.0015663137,0.013842656,0.034024213,0.052181996,0.003469177,-0.10204177,0.057150282,0.0029848868,0.049025882,-0.029316613,0.0054705734,0.0027490663,-0.014932469,0.026349025,-0.0030747044,0.014671445,-0.02810887,0.037686728,-0.011781309,-0.016270114,-0.030063957,0.04679564,-0.09674233,-0.07110779,-0.034954686,0.02795788,0.002216022,-0.08385894,0.009428425,-0.11303126,-0.035503414,-0.016937623,0.012144451,0.061356857,0.011282538,-0.055114005,0.013886283,-0.08489786,-0.082856566,0.009207832,0.009246471,0.020486124,0.0046303994,-0.00970339,-0.029750802,-0.05322118,-0.041218985,0.033785496,0.01603011,-0.05841109,-0.027445344,-0.008395431,-0.062038835,0.006092119,-0.061977237,-0.021442827,0.008951026,0.088497125,-0.05875256,0.061071746,-0.028172217,-0.031222181,-0.049471922,-0.055942807,-0.023702553,0.011584822,0.07279028,0.040724546,0.029983006,-0.05919288,-0.03306716,0.07172863,0.049428627,-0.047475457,-0.0061530937,-0.06030691,0.013880601,0.07285678,0.071238935,-0.04196011,0.06966603,-0.024862658,-0.014248438,0.11361822,-0.003562787,-0.041318964,0.067898296,-0.031292092,-0.0020456046,0.08033056,0.04220144,-0.022405481,-0.07306372,0.023283854,0.111668795,-0.050991535,-0.046498507,-0.04847596,-0.022878988,0.09625912,0.061404485,-0.043816164,0.0067788414,-0.033657525,-0.07004377,0.07990293,-0.03669806,-0.06615136,0.119659334,-0.020010084,-0.04198815,0.05045424,-0.05079124,0.0030865103,0.020104455,0.02404266,0.052374467,0.009203952,0.058196854,-0.06879275,-1.3502797e-33,0.034281302,0.01870454,-0.036887582,0.024517542,-0.008769345,0.068410456,-0.09179163,-0.002657986,-0.0007163286,-0.10226788,-0.1122218,-0.045031544,0.03500225,0.0380834,-0.016780429,-0.024389947,0.01996544,-0.02893678,-0.00873952,0.028624043,0.1053225,0.0137326885,-0.01497323,0.012479682,0.0070305937,0.01749989,-0.016636426,0.07298649,0.011166762,-0.0029722282,0.048720554,-0.13085534,-0.11610208,0.051959604,0.04981911,0.052249487,0.0259126,-0.021233588,-0.025043279,0.00060050236,-0.07937432,0.023254665,-0.027810123,-0.0012810449,0.041469794,-0.12578289,-0.05596476,0.07605763,-0.02579431,0.043994755,0.05465206,-0.0003213501,0.056344364,-0.035952948,-0.01158158,0.123287626,0.0570327,0.02566696,0.022457635,0.08351345,-0.045090996,0.054434165,0.007012529,0.06529876,-0.031163877,0.06208484,-0.088981174,-0.04176742,-0.019803027,0.05780448,0.002135435,0.01665352,0.046923377,0.012223047,0.02121389,-0.057319436,-0.0033059735,-0.011870639,-0.04732288,0.0007669625,0.001653815,-0.018196052,-0.019664701,0.066224866,-0.030541804,0.003578794,0.042647675,-0.022247445,0.05284058,0.05945457,0.05420405,-0.015487424,-0.041577794,-0.049858823,0.083382934,-5.44821e-34,0.10240115,-0.0726168,0.06965257,-0.024798691,0.03298391,0.10781396,0.071773954,-0.10499188,0.06195071,-0.06832957,0.077703685,0.0676147,-0.0011615892,-0.02995987,0.0702764,0.034583934,-0.043206226,0.06449954,-0.0021071525,-0.042128365,-0.061831914,0.12649333,0.010075429,-0.024916966,0.031335194,-0.04930546,-0.033820156,0.044118647,-0.013639143,0.0030545879,-0.036888033,-0.01129889,-0.04113631,-0.025897468,-0.02748095,0.03377701,-0.029331557,-0.01303529,-0.013442389,0.017281825,0.047822405,-0.058360826,-0.06784185,0.042012487,0.021632897,0.04151876,-0.020567851,-0.020665811,-0.0032256336,0.015290327,0.09048231,0.0335582,-0.05232727,0.0175772,0.12959132,0.03232433,0.060156647,-0.050973028,0.027041642,-0.0007505394,-0.062863454,-0.07721909,0.08002194,-0.011941877,0.04143957,-0.0035059925,-0.030002799,0.06493908,0.059690997,-0.038338147,0.103629455,0.05183035,-0.017304087,0.06550272,0.0185163,0.0050882543,-0.053942367,0.009081058,-0.018373212,-0.05020619,-0.106355526,0.0147557,0.008901654,-0.07404431,0.0078085554,-0.03248879,-0.0016023053,0.012345535,-0.04039718,0.06267343,0.002881731,-0.01376759,0.017360654,0.06646399,0.018001547,-2.1028354e-08,-0.01421324,-0.013067409,0.047157407,-0.052060366,-0.02484539,0.036850993,0.01839953,0.008264125,0.020265726,-0.010690799,0.02672066,0.10205401,0.04561818,0.055095162,0.040448833,0.027937826,-0.033859897,-0.012520146,-0.038270872,-0.022650052,-0.110770665,0.035084233,-0.07213731,0.028036557,-0.011281543,-0.0051285834,0.0038781075,0.018261597,0.03495173,-0.1315261,0.0024545484,-0.0077348906,0.048630387,-0.03120427,-0.08240372,0.07845692,0.06703014,0.01210162,-0.027744569,0.097518146,-0.016778972,-0.13782236,-0.05161235,-0.025278118,-0.028725674,0.033153,0.020939063,-0.028328594,-0.07424987,-0.014568461,0.049201384,-0.0064003356,0.040494446,-0.082498625,-0.067235336,0.029584795,-0.03338367,-0.07386524,0.028983938,-0.054415695,0.043675523,0.007973987,0.1523145,-0.0045224866 +1.2.1.53,"With EC 4.2.1.87 octopamine dehydratase, brings about the metabolism of octopamine in Pseudomonas.",384,1.0,-0.008160838,-0.058785617,-0.048069824,-0.04947777,0.016447501,-0.02352564,-0.08318868,0.057283893,-0.046211522,-0.023344506,0.005246362,-0.1129636,-0.052719094,0.041220576,-0.066370495,-0.00097427174,-0.073220104,-0.053264484,0.042788465,0.0634119,0.079430304,-0.021544527,-0.05949965,-0.028229836,0.038274646,0.10773915,0.019467546,0.022140162,-0.021024048,-0.021943795,-0.041249175,0.006933088,0.052990727,-0.10140438,0.07778674,0.057552055,0.015847016,-0.018762834,0.027563175,0.08500207,0.013060869,0.0125252,-0.026111493,-0.041438133,-0.015790317,-0.06147301,0.04755583,0.067350544,0.019975323,-0.053424414,0.018636785,-0.055117223,0.0042396574,0.08781462,0.027870923,0.016582614,-0.001763437,0.018374838,-0.08835642,0.017693477,-0.0050272853,0.04745858,0.024140935,-0.049404792,0.0453063,0.0035232326,0.06546844,-0.007881518,0.0680036,0.016597778,-0.054942112,-0.0067492006,0.083926514,0.06397261,-0.00080805435,-0.046875805,-0.016070502,-0.1410086,0.041009843,-0.025211053,-0.02430672,-0.05331023,0.0036259727,0.0016652152,0.05989042,-0.07968483,-0.024044137,-0.0010071346,0.063656755,0.04712554,0.0035764524,-0.019265005,-0.019660328,-0.08143499,-0.03358126,0.04543206,0.022055162,0.062204964,0.051739074,-0.069534115,0.024412055,0.0019215146,-0.12779568,-0.010899418,0.066216715,-0.02329202,0.06836179,0.18084928,-0.014360843,-0.011049635,0.0470448,-0.034848746,0.025109455,0.009734237,-0.04750263,0.089212395,0.010141376,-0.071584806,-0.10847064,0.029557377,-0.05250527,0.013001098,0.052922115,0.05648899,0.044981968,0.02131693,-0.112611026,1.9163605e-34,-0.007317,0.040517647,0.013126678,-0.057462815,-0.025359971,0.012142053,-0.083613105,0.022601891,0.04387994,-0.048414294,-0.05206744,0.011405148,0.050470784,0.0064749075,0.0014218801,-0.039726224,-0.044316135,0.02221076,0.06925229,0.015712742,0.10040863,0.012799679,-0.039431617,0.0030870393,0.025200024,0.07815024,0.041052382,0.0010905836,0.029459074,0.0274404,-0.018986719,-0.06902074,-0.057945598,-0.030848717,0.07136168,-0.0040052314,-0.06881197,-0.0013784583,-0.09462781,0.10088096,0.016868403,0.07293888,0.028704561,-0.085608326,-0.018020283,0.0076100035,-0.046892624,0.09828855,0.06339018,0.010344794,0.015216415,-0.04906265,0.053561248,0.010190868,-0.04969964,-0.097248115,-0.06427552,-0.035381638,0.041860558,0.04306604,0.07766091,0.05708195,-0.043586984,0.0029588526,-0.039966457,-0.040372074,-0.037140466,-0.04406233,0.029006265,0.021844938,-0.13264333,-0.03678308,0.043554913,0.004384707,0.05045826,-0.039271276,-0.08810877,0.025551805,-0.015157255,-0.0015921482,0.01948403,-0.08370137,0.04649694,-0.04654594,-0.024295399,0.058005087,0.04126299,0.050597113,0.0046766214,0.010003686,0.08967552,-0.11576505,-0.057263706,-0.0061891126,-0.031977482,-1.4221596e-33,0.0324462,-0.03388545,0.027031628,-0.03492328,0.0043582465,0.08522475,-0.024749618,0.03757845,0.0641099,-0.06053524,0.072104365,0.055603452,-0.0069823726,0.013428749,0.05484382,0.02391193,-0.019411102,-0.013469867,0.028664805,0.016596394,-0.024248786,0.010509762,-0.085522406,0.06496326,0.08890948,0.01507429,0.020777727,-0.00034838187,0.0766371,0.022755753,-0.054199506,0.059957273,-0.07513484,-0.0065292194,-0.008411807,-0.004772538,-0.07267729,-0.0014400741,0.01982631,0.016704988,0.11230344,-0.0067322315,-0.009390939,0.1115721,0.006884692,0.021958519,-0.035170488,0.058268704,0.02053985,-0.003015592,0.04451801,-0.0459864,0.0015614581,-0.010745646,0.032564785,-0.10528808,-0.05274519,0.026852757,0.0070787193,-0.010899894,-0.023202114,-0.08241384,-0.014597121,-0.013894082,-0.03361429,0.031307187,0.0070187184,0.069193736,-0.051242296,0.0074668955,0.051914018,-0.041659493,-0.025463143,0.06806691,-0.03532244,-0.027523251,-0.06798513,0.011728857,0.06574338,-0.017695472,-0.04345401,-0.046972904,0.06453889,-0.009207287,0.003031831,-0.008461746,0.040184952,0.10544639,-0.06829152,0.009559609,-0.030622125,-0.059220236,-0.009113767,-0.003952883,0.011920288,-2.584736e-08,0.059794668,-0.068622105,0.046851378,0.047409844,-0.015943356,0.056919925,0.058100037,0.07797277,0.02493454,-0.00013106775,0.05644811,0.040523604,0.07997785,-0.012339879,0.0015771696,0.031011544,-0.06602308,0.010893729,-0.020018183,-0.024724578,-0.11214179,-0.08116597,-0.09818494,0.0501504,0.0025875978,0.014994208,0.061607752,0.021633454,0.014450942,-0.076914206,0.0047332244,0.015636262,-0.040590096,-0.013509756,-0.07527804,-0.02505609,-0.0024645168,0.03176559,-0.02663328,0.0049905204,0.025614945,-0.058635667,-0.103532985,0.00034822174,0.12744164,0.0395137,-0.014504983,-0.009848944,0.011183564,-0.06693934,0.0606295,-0.02537325,0.03034553,0.018506553,-0.07932688,-0.03528827,-0.07763612,-0.0911415,-0.07619476,0.014271101,0.06441013,0.029319555,0.096798286,-0.048271567 +1.2.1.54,Involved in the degradation of arginine in Pseudomonas putida (cf. EC 1.2.1.19 aminobutyraldehyde dehydrogenase).,384,0.99999994,-0.021929095,-0.08259611,-0.11014001,-0.02790496,0.038464252,0.09388291,-0.049531713,0.074763276,-0.0047186767,-0.023123207,0.0025899392,0.028568376,-0.033108503,0.0777214,-0.07548313,0.05428889,-0.08421885,-0.047722887,0.027538328,-0.035819795,-0.0021969134,0.12974074,-0.12435626,-0.016290482,0.030174641,-0.014257965,-0.0072058667,-0.015335059,-0.050118662,0.010232745,0.02162668,-0.068036914,0.046594385,-0.085918605,0.08206406,0.02747932,-0.0059686247,-0.014268914,0.11143206,-0.015104668,-0.009217788,0.024784433,-0.112317726,-0.06992485,-0.050970625,0.035299152,0.09853449,0.05306228,0.0110396845,-0.016914617,-0.012779073,-0.011987699,0.054469164,-0.025913985,0.03305923,0.019235529,-0.03635564,-0.017254941,-0.07660194,0.011063565,-0.014908439,-0.015002696,-0.004390656,0.0022414783,-0.019137418,-0.03363041,0.11658286,-0.014491709,0.11427176,-0.0070477445,-0.04625874,-0.03598134,-0.009180986,0.022384094,-0.05979128,-0.013899288,-0.021248007,-0.095866755,0.050084554,-0.07367985,0.0057344544,-0.05275241,0.027811084,0.048562262,0.021933962,-0.09241855,0.050146785,0.019927425,0.026709137,0.0081964135,0.035325747,-0.010675628,0.012322662,-0.0306863,0.021847695,0.020424578,0.03581747,0.08225051,-0.018973647,-0.030930549,-0.027184337,0.021831496,-0.06707539,-0.091453396,0.021313712,0.019252483,0.08230382,0.072242,-5.1535684e-05,0.037769437,0.010342957,0.01773971,-0.0077132457,-0.0060085505,0.008465322,0.060104035,0.1311493,-0.06356175,-0.13105357,-0.032410912,-0.054983497,-0.021333449,0.07257113,0.09363486,-0.015287654,0.031339224,-0.028171463,-1.570601e-34,0.0231011,-0.0191911,-0.017432928,-0.06829285,0.066547394,0.0031090504,-0.0629269,0.06681262,0.1204363,-0.010472442,-0.021876402,-0.10792139,0.02889751,-0.0135749085,0.0051799687,0.03013491,-0.02806135,-0.023372602,0.03165723,0.041100986,-0.009326612,0.042068977,-0.03931661,0.014292136,0.04110694,0.0041554603,0.08143413,-0.0070241643,-0.059051927,0.0031001472,0.03550911,-0.06550756,-0.13774383,-0.053258166,0.01891686,-0.07685753,-0.0076100486,0.054039247,0.021673022,0.048286542,0.041411817,0.07581862,0.0010773524,-0.054686073,0.062386755,-0.07354832,-0.038593896,0.19270465,-0.02591761,0.07981682,0.0052922587,-0.07954154,0.069782674,0.024384603,-0.038918108,-0.01259713,-0.0040045474,0.036467932,0.09635031,0.037664533,0.053685065,0.0113442065,0.024589911,0.026390947,0.019776499,-0.047969125,-0.050770424,-0.0070750583,0.043899886,0.018338222,-0.09275458,0.016988514,-0.009484597,-0.036005147,-0.05346119,-0.09427602,-0.10888736,0.08679335,0.054140292,0.001345578,0.019087601,-0.0049372134,0.035779838,-0.024678435,0.008715126,0.012744275,0.053901862,0.0030201524,-0.02946264,-0.010432638,0.083942175,-0.077726,-0.050836418,0.010776479,0.014894535,-4.8287526e-34,0.06490013,-0.035815153,-0.013880629,-0.013456299,-0.036734432,0.071957454,-0.024472838,0.11530967,0.015015797,-0.04476883,0.054513857,0.05149045,0.029210698,-0.0027946546,0.060814597,-0.007677413,-0.025146699,-0.005864899,-0.0009878062,-0.06376408,-0.030914705,-0.03762012,-0.043236185,0.019873586,0.043772187,0.03714977,-0.07090223,0.012303733,0.017057987,0.07665113,0.007704791,0.028115515,-0.06305986,0.0006832293,0.044586238,-0.0065074856,0.0042293095,0.024875645,-0.011697901,-0.015043767,0.039051197,0.051660202,-0.036904853,0.07355769,-0.015853954,0.06648359,-0.08806005,-0.06134543,-0.0013573078,-0.13345778,0.07176845,-0.07464175,0.019503083,-0.0069801314,-0.026207576,-0.05268928,0.020226168,0.03188389,-0.059583604,0.015564274,-0.018774426,-0.08651381,-0.012815826,0.018088121,-0.035296246,-0.011920265,-0.04996093,0.09383459,-0.03478587,-0.026931379,0.03240442,-0.0084112985,0.0017887016,0.087148264,-0.075573884,-0.008236094,0.014273405,-0.02993489,0.06917831,0.014376561,0.028630387,-0.038672622,-0.080512546,-0.02209534,-0.0101637095,-0.027928421,0.02390496,0.11287799,-0.044524156,0.002805383,-0.026837908,0.008090512,-0.047809154,0.02365482,0.048059575,-3.024428e-08,0.08472829,-0.011314028,0.0625744,0.0933569,-0.0222859,0.016271334,0.025696596,0.0788631,0.028995859,-0.05154426,0.006893532,0.032842286,-0.016515765,0.029150832,-0.008510529,0.000719393,-0.121701844,-0.02974874,-0.003034441,0.01913257,-0.09138764,-0.004626739,-0.07712943,0.0064836596,0.010089698,-0.042713657,0.08911325,-0.0072959014,0.016770989,-0.024126288,0.014554384,0.0004292363,-0.009212901,0.01790323,-0.067208365,-0.010756446,0.028689394,-0.010378029,-0.0041783885,0.009893995,-0.05811428,-0.028866518,-0.08025265,-0.06710752,0.102031045,0.025484145,0.022205839,0.024071928,-0.052850705,-0.054973125,0.07772364,0.035838444,0.060163267,0.005760073,-0.07514379,-0.0045706704,-0.07680898,-0.06779099,0.004731146,0.003186376,-0.00916389,0.032984134,0.07395721,0.0441173 +1.2.1.57,"Also acts on acetaldehyde, but more slowly.",384,1.0,0.020743035,-0.099902116,-0.029081969,0.10166596,0.11188784,-0.009252483,-0.06419885,-0.021692138,0.047618076,-0.024879437,0.05127792,0.047347914,-0.07546169,0.032558843,-0.019913483,0.06934645,0.011589395,-0.007966984,-0.028647574,-0.0024466873,-0.00495044,-0.036127713,0.004868872,-0.0666391,0.08138541,-0.0038775573,-0.0006996394,0.0031160233,-0.0039929627,-0.08164279,-0.0022139316,0.04248604,-0.03428884,-0.04692204,0.024632014,0.010668724,-0.024324428,0.009147946,0.04103439,-0.040216316,0.040511146,-0.037482478,-0.045813255,-0.025512816,0.009765105,-0.037378535,0.007595082,0.011083236,0.011000862,0.01644341,-0.0046740416,-0.032670416,-0.038764093,-0.049700182,-0.030242113,-0.016127927,-0.05567212,0.04041437,0.010317279,-0.00047806947,-0.080888174,-0.042215697,-0.061656404,0.03878434,0.05118854,-0.023285056,0.10169846,-0.06708241,0.012695383,0.0057942728,-0.0071894606,0.013151565,0.027722208,0.046678003,0.027019437,-0.030881392,-0.052822623,-0.0784108,0.07881028,-0.0024816173,-0.041469093,0.054743677,0.021943301,0.05324937,0.040015172,0.004507936,-0.0043975445,-0.07980418,-0.1266809,0.047296554,0.025667885,0.026462387,-0.012601728,0.009910512,-0.019584289,0.013014669,0.1130158,0.02548344,-0.006974733,-0.031089881,-0.06901604,0.0044159275,-0.06483699,-0.06483568,-0.027949514,-0.0015920955,0.04992378,0.041873667,-0.027758084,0.020848988,-0.018755516,0.000415323,0.0077759475,-0.0143603,-0.06379727,0.089453585,0.08768958,-0.026493289,-0.08156829,0.032234922,-0.0017773762,-0.021567225,0.01410078,0.014230324,-0.008413939,0.06425327,0.024056599,-7.926276e-34,0.02382507,0.00012955925,-0.00056540093,0.0016884456,0.067139134,-0.019750431,-0.12278399,0.02665372,0.04550584,0.03526756,0.009337629,-0.10408644,0.00085467036,-0.015874002,-0.009051477,0.01353466,-0.0840622,-0.048606895,0.0098602325,-0.0315931,-0.0065127704,0.036268823,-0.04749323,0.027328605,-0.048342466,-0.031703163,-0.022343375,0.033671174,-0.0360658,-0.006356746,0.077917784,0.00026042142,-0.07639214,-0.018033985,-0.04919342,0.08695807,-0.0076962053,-0.011309647,0.035400983,0.012373148,0.04024975,0.06024173,-0.0482473,-0.05011841,-0.017576257,-0.051049046,-0.076443516,0.100783974,0.018939363,0.04763177,0.05747148,0.015598485,0.08245253,0.01690504,-0.028973917,0.07397816,0.04557666,-0.06776926,0.022524385,0.053774867,0.002235236,0.04258686,0.017467719,0.011097983,-0.0317734,-0.0054722372,-0.04911509,0.009971621,-0.043187786,-0.019337684,-0.034904554,-0.02596417,0.12386964,-0.040399447,-0.031470194,-0.03314661,-0.048349947,0.016753273,0.019633096,-0.046378333,0.035127446,-0.05981759,0.07966611,-0.04041283,-0.0133891525,-0.034272585,-0.09270445,-0.032506812,0.017706366,-0.018206196,0.08468133,-0.06256289,-0.035863318,-0.029585341,-0.032314908,-5.945471e-34,0.058602583,-0.11805075,0.028832402,0.024922816,0.009339024,0.058612928,-0.042350568,0.060284365,0.022298135,0.006263142,0.12048771,0.015401431,-0.044176977,0.0063078166,0.04684011,0.0727491,0.06560089,0.113029644,0.033670597,-0.010695108,-0.04397594,0.07366759,0.04243182,0.060424555,0.06833093,0.033447888,-0.004582967,-0.04856091,0.03262317,0.03491702,0.0063889534,-0.025673695,-0.09755982,-0.0852034,0.0053057917,0.012781362,-0.035768673,-0.028137898,-0.09120461,-0.006663842,0.0023820957,-0.054643027,0.06386509,0.06369432,0.06951326,0.05077208,-0.04447911,-0.06912729,-0.07569166,0.04069349,0.07585644,0.021241562,-0.10805526,0.07074534,0.042362195,0.0958427,0.024771811,-0.095509976,0.0043722223,0.053044684,-0.07435378,0.028072895,-0.05575316,-0.09914592,0.04239986,0.031312827,-0.043071162,0.08390079,0.1294063,-0.035047486,0.11059603,0.031057006,-0.03793628,0.051873665,-0.062323533,-0.07807077,0.055722278,-0.0022801678,-0.0121659245,-0.026263297,-0.05401961,0.0008411845,-0.008980638,-0.03372561,-0.082367636,-0.057924606,-0.08886868,0.046786435,-0.036927577,0.06715839,-0.0053529516,-0.020470377,0.0290004,0.035800386,0.020534318,-1.797231e-08,-0.015124872,-0.009656899,0.11125313,0.013547428,-0.035246063,-0.008473514,0.10033931,0.09452477,-0.010337607,-0.07574389,-0.021880124,0.13804969,0.10710565,0.032691207,0.018152514,-0.02664297,-0.020991495,-0.011373938,-0.0641782,-0.05851814,-0.123562284,0.0201632,0.030711478,0.04968273,-0.03220715,-0.06420801,0.039270565,0.056179915,0.033767622,-0.055165593,-0.023616636,0.060141977,-0.04839264,-0.032455977,-0.07353343,0.022097265,0.08350712,-0.039461255,-0.010369076,0.026754081,-0.06545537,-0.05170947,-0.07387412,0.006956359,0.013344125,-0.046975173,0.017712828,-0.0004143053,0.0039648674,-0.013933354,0.1036736,0.04969482,-0.02437058,0.011023922,-0.052181736,-0.007514929,0.011169765,-0.049354553,0.10722634,-0.06964181,0.06074593,-0.020079423,0.12944914,0.023659306 +1.2.1.58,Requires thiamine diphosphate as cofactor. The enzyme from the denitrifying bacterium Azoarcus evansii is specific for phenylglyoxylate. 2-Oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate. Also reduces viologen dyes. Contains iron-sulfur centres and FAD.,384,1.0,-0.045234133,-0.014346167,-0.06744004,-0.04816706,0.061363056,-0.011444158,-0.010951943,0.013340362,-0.030313605,0.02668829,0.032403633,-0.05767833,-0.015647871,0.039637145,-0.07708105,0.015715064,-0.06793207,0.021271419,-0.0022442872,-0.08284845,0.030706504,0.112263486,-0.027619857,-0.04111918,-0.011324522,-0.02554696,0.007509039,0.0012058518,0.002800002,-0.0445773,-0.022230402,0.00220429,0.023799041,-0.093161665,0.005624238,0.06636542,-0.05451255,-0.07419485,0.06006004,0.033886492,0.023706466,0.04790456,0.014559435,-0.015399618,-0.078615904,-0.0002296838,0.06581676,0.058183186,-0.008664461,-0.0016303484,-0.0707388,-0.0016478066,-0.021450162,-0.0019694518,0.0037448406,0.01601014,0.010982207,-0.057228316,-0.014745156,-0.019105742,0.03854629,-0.022711532,0.018776419,-0.03400705,0.025172386,-0.03739127,0.04681812,-0.06539768,0.021489685,-0.07620569,-0.058835316,-0.04046387,-0.0028790275,-0.0018559182,-0.022394812,0.06697774,-0.018851515,-0.06671917,0.07946395,-0.07641087,0.050987493,-0.029967973,0.054594778,0.08774677,0.06615181,-0.042598903,0.020690553,-0.062460836,-0.027044913,0.0014499524,0.07010462,0.06505897,-0.032540366,-0.028334145,-0.06279445,0.037760507,0.04173615,0.044699054,0.0061353985,0.011654925,-0.01577308,-0.0021718987,-0.014713929,-0.09679943,-0.11625428,-0.059521742,-0.0020511348,0.10057556,0.02170277,0.08675464,0.007992588,0.006030053,0.08184117,-0.016263017,0.025821455,0.09896185,0.09188177,-0.08624952,-0.0688264,-0.046066307,0.0065116133,-0.032640167,0.04930792,-0.036354333,-0.018782016,0.038167953,-0.08728313,6.923845e-33,0.1144162,0.09997411,-0.019676391,-0.03475059,-0.015825141,0.0060624834,-0.14920752,0.04666472,0.023769418,-0.086049125,-0.03261938,-0.092074,0.041245323,-0.0047523766,-0.042794738,-0.054422095,-0.018161079,-0.018277625,0.021331238,0.018149942,0.025995055,0.07501836,-0.060780525,0.031978205,0.004896946,0.007194092,0.023700608,0.03966859,0.005165243,-0.018053634,0.08395648,-0.10200503,-0.12964492,-0.043695673,0.05574782,-0.015435951,-0.06894783,-0.0036679695,-0.082858644,-0.017136207,0.025774598,0.089698166,0.025827443,0.01129878,0.07968304,-0.06395084,-0.055976607,0.13351944,-0.0042867484,0.068273276,-0.024044167,0.04087057,0.08445478,-0.0020719995,-0.03191426,0.027931897,0.04397827,-0.009092798,0.062600605,0.013101571,0.00075938937,0.008109384,-0.006925125,0.0821818,0.035992984,0.022561256,-0.02792967,-0.008231525,0.043867197,0.01920586,-0.026214443,0.0152315125,0.044185583,0.009215741,-0.056314424,-0.069346234,-0.010801606,-0.01088534,0.0339569,-0.05389202,0.011741298,0.0030179645,-0.006405667,-0.060668014,-0.03906937,-0.0840325,0.0054852716,0.0694746,0.002805544,-0.013963104,0.08515908,-0.080675915,-0.05141188,-0.049032148,0.018370382,-6.173897e-33,0.078822345,-0.08051115,0.032455523,-0.033070438,-0.009833338,-0.0147454245,0.071174085,0.030864028,0.044432953,-0.07176219,0.079778254,0.043255102,0.062098846,-0.03038411,-0.0053849225,0.053799037,0.032372955,0.055958856,0.008479559,-0.035291027,0.0017630304,0.084945366,0.045282256,-0.02559252,0.00174426,0.04429172,-0.06327209,0.042332243,0.009786349,0.041162595,0.0006007748,0.045496393,-0.0778001,-0.09248825,-0.08544195,0.0032245745,-0.003547295,-0.033095457,-0.024049183,0.06513044,0.021208202,0.02668467,-0.0030165159,0.12292509,0.024437757,0.042522337,-0.11339061,-0.059544105,-2.945209e-05,-0.023775458,0.01903326,0.014191433,-0.045719426,-0.007915864,0.03729124,0.043025054,0.04096446,0.03601021,-0.04782276,0.063279286,-0.023290299,-0.033913497,-8.062721e-05,-0.016060844,-0.0030473392,0.027731365,0.012298841,0.09888296,0.07431726,-0.047963373,0.052048866,0.0757559,0.06405405,-0.037583627,-0.027760888,-0.017756734,-0.009997805,0.07034727,-0.021662045,0.0031934767,0.023150936,-0.03281927,-0.030948568,-0.034909118,-0.021736378,-0.04709286,-0.017233206,0.00898868,-0.07203229,-0.007188628,-0.078248635,-0.08682237,0.021259388,0.033401504,0.020596487,-3.934251e-08,-0.028194046,-0.017115984,0.07738943,-0.035201438,0.0035428647,0.046715613,0.03842094,0.02201463,0.06193794,-0.049257156,0.035951175,0.08210799,-0.023139033,0.06026204,0.074628495,-0.030254642,-0.010783538,0.03754587,-0.09648249,0.008864233,-0.043109424,-0.012544027,-0.10230926,0.049826883,0.03696398,0.0045547416,0.07914092,-0.06283486,-0.037934646,-0.019288762,-0.024309412,0.0690318,0.00705331,-0.098630525,-0.099291205,0.03606884,0.05940672,-0.020314844,-0.06997181,0.012212494,-0.008840506,-0.015041116,-0.16962442,-0.00054111704,0.054550745,-0.031191783,-0.0048309183,0.06115295,-0.030496385,-0.019684939,0.01173756,-0.013405904,0.01857042,-0.023440786,-0.0907196,-0.003481204,0.059038542,0.044080373,-0.022493277,0.026549926,0.037768435,-1.528705e-05,0.20316757,-0.051601745 +1.2.1.59,"NAD+ and NADP+ can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) and EC 1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), which are NAD+- and NADP+-dependent, respectively.",384,1.0,-0.05427707,-0.001317895,-0.058772594,-0.058660205,0.045517646,0.077921554,-0.0850943,0.0027219774,0.006953467,-0.0035118891,0.050819848,0.026395911,-0.08776787,0.016426269,0.037855487,-0.045887433,0.055122532,0.006330484,0.047542904,-0.034161463,0.016472774,-0.027175944,-0.023251949,-0.02515813,0.09516533,0.05129727,-0.05702683,0.014042112,0.03153048,-0.045445003,0.002545025,-0.014819943,-0.026515795,-0.08150501,-0.060735278,0.034674585,-0.033260133,-0.04131712,-0.043025054,0.05987643,-0.0023917074,0.060389128,-0.022526678,0.038245462,-0.049572267,-0.082329854,0.0055721845,0.04446408,0.0117580695,-0.018008746,-0.0039220224,0.03387263,-0.007058473,-0.020106787,0.055382185,0.009164631,-0.036578834,0.02013219,-0.0801137,-0.081447,-0.026143696,-0.06830583,0.065214336,0.023976646,0.083739735,-0.029541545,0.09418163,-0.053813726,-0.026648492,-0.0003140449,-0.15994024,-0.0004145376,0.019353053,0.010753612,0.0006528178,0.12383356,-0.1258643,-0.035283636,0.07125914,0.013013636,0.061683293,0.045066476,-0.03735169,0.028203132,0.051844288,-0.010168898,-0.013716792,-0.038084913,-0.07210173,-0.039442252,0.04197063,-0.002783001,0.075355664,0.03432354,-0.10443692,0.033578467,0.011487237,0.08856752,-0.030365678,-0.11706237,-0.010523384,0.1091631,-0.02948534,0.015362475,-0.034704886,-0.019878231,-0.035982616,0.11740474,0.010004588,0.0350212,-0.017760204,-0.010480863,0.00470568,-0.07250599,-0.027855413,0.10947098,-0.000113255184,-0.041961946,0.04211261,-0.054398604,0.07942842,-0.098114826,0.033493947,0.0026610729,-0.017899308,0.015474878,-0.10513134,3.1643143e-33,0.1025031,0.048466694,0.0031398358,-0.019782273,-0.023402527,-0.006557457,-0.12603818,0.039036054,-0.017650018,-0.07566828,-0.015479425,0.036794007,0.07216041,0.03279388,0.003283243,-0.0023679128,-0.05615746,-0.052026466,0.005743441,0.0015142001,0.06903521,0.09624441,0.0058413967,0.042010143,0.0786654,-0.007204961,-0.031046966,0.07851483,-0.073588476,0.004550824,0.024109434,-0.11236312,-0.10283561,0.04222428,0.0058947485,-0.04188355,-0.050368,-0.08155578,0.026958812,-0.012820712,-0.053130817,0.031224433,0.04156978,-0.07488968,0.014274535,-0.07585749,0.002470204,0.01785225,0.004773446,0.03466386,0.017127452,-0.00014136934,0.101281695,-0.04436853,0.0043172482,0.05373744,-0.0047933026,0.03575743,0.0047902283,0.088233195,-0.059910726,0.05303853,0.0073432475,0.045028687,-0.042136043,0.028627409,-0.08390131,-0.056690276,0.078962676,0.0528899,0.025782568,0.06389372,0.0458986,0.023374684,0.026758732,-0.049969457,0.052115593,0.024162928,-0.03019427,0.049487207,-0.036000222,0.015960865,-0.0162044,0.0018215119,-0.0229837,0.07930709,-0.0057408907,-0.008420467,0.052061528,0.024880692,0.009690557,0.021852126,0.06318855,-0.05077149,0.0038647137,-4.032366e-33,0.08911671,-0.035121806,0.029727556,-0.08905805,-0.03210274,0.11635187,0.07586575,-0.15520471,0.022622297,-0.052240398,0.014506287,0.066681385,0.039826553,-0.043474775,0.07244848,-0.033330116,-0.06284039,0.013869459,-0.012194695,-0.011342171,0.04782688,0.070615076,0.015978986,-0.023656974,0.083776236,-0.043408927,-0.066460334,-0.015135546,-0.0112186335,-0.004278143,-0.0348804,0.04269438,-0.03790749,-0.03398068,-0.046183906,-0.0036461747,-0.094999716,0.0138263265,-0.052359257,-0.04028482,-0.0055132625,0.050688606,0.016716197,-0.0035974572,0.0627894,0.01235045,-0.110946804,-0.024618216,0.033484027,0.03833861,-0.019122891,0.060578246,-0.1472225,0.012020887,0.044944603,0.026223086,0.04191947,0.07348855,0.07530795,0.06515599,-0.045587063,-0.0040053055,0.05586729,-0.023588274,0.052238807,0.018275777,0.019017782,-0.014646886,0.045706306,0.026744682,0.023200456,0.043476168,-0.0061997906,0.038426165,0.0038689524,-0.005152449,-0.073018394,0.0414287,-0.06820072,0.0031463876,0.012772614,-0.013628064,-0.028118107,-0.014099564,-0.011210531,0.035563823,-0.05243354,0.05302918,-0.0060372613,0.028066529,-0.005248987,0.00068804674,-0.034388464,0.0414933,-0.022488337,-3.9218275e-08,0.037228286,0.0057563107,0.0813753,-0.05820125,-0.0071368814,0.022365214,0.017998653,-0.036092307,0.04396901,-0.018176291,0.06158867,0.078148894,0.024139741,-0.015539084,0.016579285,-0.01749336,-0.042195007,-0.028194427,-0.023611767,-0.0007177007,-0.03771815,-0.023853235,-0.11656445,0.11211829,0.022484519,0.008566126,0.02202464,-0.010795382,0.04337081,-0.040582955,-0.023627069,0.025509866,0.06825583,-0.041819513,-0.030676654,-0.023339923,-0.015012653,0.036706313,-0.09320577,0.076268286,0.011896262,-0.10603334,-0.03616,0.025598517,0.03286551,0.042017333,0.07234908,-0.060143463,-0.085760444,-0.02369909,0.0027688704,-0.07269515,0.010375706,-0.06569207,-0.033471346,-0.0006808005,-0.008445865,-0.09037589,0.03872993,-0.043966707,0.06909535,-0.034777932,0.12041286,-0.011169955 +1.2.1.60,Involved in the tyrosine degradation pathway in Arthrobacter sp.,384,1.0,0.0059778932,-0.014794264,-0.06505829,0.0010261245,0.024896305,0.0009430686,0.02559128,0.08843242,0.025322173,0.055383474,-0.042951945,0.009857877,-0.029977214,0.057661172,-0.0210565,0.11062062,-0.082448885,-0.018700114,0.027386317,-0.027361449,-0.019918168,0.024523651,-0.013969508,-0.02980594,-0.072992325,-0.038170677,0.025658472,-0.05069147,-0.07729422,-0.03287529,-0.016703783,0.022714708,0.05926835,-0.06514679,0.07195273,0.08915093,-0.056164246,-0.0743988,0.034825675,0.025553685,0.025010476,0.05839572,-0.118361644,-0.04464909,-0.011172985,0.03143604,-0.00020181372,0.006894481,0.034266245,0.059482403,-0.05739465,-0.026059981,0.007039412,-0.012219962,0.0025441085,-0.018311303,-0.012431043,-0.020645617,-0.07731606,0.042567957,0.04983212,0.046082083,0.051809136,-0.034804482,-0.024006294,-0.0014495007,0.03398781,-0.015026516,-0.040721986,-0.022227371,-0.115119606,-0.032154676,-0.0383718,0.059781145,-0.026619148,0.0056574377,0.0001399386,-0.041152697,0.026522363,-0.08315193,-0.048574794,-0.049494024,0.011648442,0.06835895,0.0040480914,-0.006034956,0.013789854,-0.06079787,0.0885318,0.08197098,0.060542773,0.012805928,0.04273175,-0.060132317,0.019783724,-0.03949876,0.04204426,0.03995209,-0.0098851975,-0.017103761,-0.08634842,-0.0046384055,-0.04256228,-0.038415127,-0.03366655,-0.007818096,0.01697199,0.09860409,0.019317733,0.04824785,-0.006450274,0.046608567,0.093338564,0.006464319,0.009950185,0.005424959,-0.019765403,-0.0052988674,0.018595051,0.01261296,-0.0015028868,-0.019887079,0.06764465,-0.0019581993,0.038498297,0.031010186,0.04986347,-1.799841e-33,0.06818977,0.021581735,0.045307502,-0.0046537234,0.0075746295,-0.042361625,0.004005072,-0.040262226,0.059526216,0.01130748,-0.04674129,-0.11494403,-0.0027827993,0.0014321315,-0.013991377,0.07837536,-0.064029545,0.043719612,0.0018454791,0.07203837,-0.018912446,0.0808103,-0.049313787,-0.021987276,-0.027904937,0.13202494,-0.053361997,-0.019468544,-0.07954068,-0.025691466,0.07507161,-0.0055452343,-0.099488534,-0.0047607543,0.048458803,-0.014666021,0.030972311,0.03998279,-0.053485386,-0.05038398,-0.003596198,0.04750859,0.024010703,-0.023520749,0.07706261,-0.060399115,-0.036177043,0.11447581,0.006903868,0.01253275,0.040399276,-0.036421813,0.10248976,0.060644764,-0.017370434,0.0035072593,-0.0449456,-0.086707026,0.08901329,0.06557449,0.07941303,0.0124118645,0.017282922,0.036391243,0.069161065,-0.037521016,-0.07080155,-0.03475605,-0.034659825,0.030218916,-0.0010100752,-0.09587102,0.07184469,0.05450099,-0.03719475,0.022349715,-0.09297616,-0.014493908,-0.014621461,-0.06906282,-0.019772265,-0.008828672,0.06177443,-0.028518898,0.030266713,0.056703832,0.03343827,-0.0699376,-0.026868433,0.053059395,0.027233435,-0.06377784,-0.1214427,0.019745862,-0.0093540065,6.1857814e-34,0.0900804,0.010303932,-0.06427618,-0.054373365,-0.04999738,0.0048037744,-0.042708617,0.08424781,0.027475856,0.0145574175,0.1110132,0.026095571,-0.021040503,-0.07051682,0.011318898,-0.06282697,0.079830475,0.06128167,-0.09566594,-0.06769787,-0.052948304,0.03017659,0.011710082,-0.0662397,0.005579668,0.020709684,-0.05508082,0.12737311,0.036826696,0.032596886,0.033620752,0.04037853,0.013896631,-0.025475672,0.032299396,-0.004139513,-0.09219349,-0.07474617,0.07972941,-0.029852277,0.08475851,-0.07595846,-0.0021749348,0.0102422545,-0.00024479209,0.08161341,-0.13659365,-0.03854183,0.035205115,-0.015370771,-0.005118138,-0.06816223,0.010689421,-0.077418186,-0.022953568,0.060851,0.021590926,-0.042900488,-0.057141263,0.058848765,0.049002647,0.08557052,0.12222389,0.048893612,-0.030731913,0.050659716,0.020957245,0.12393841,0.057170052,-0.006741304,0.022585263,0.07905037,0.07612967,0.054103497,0.00902279,-0.07852288,-0.105112635,-0.023882428,0.07870305,-0.06295018,-0.06633839,-0.002396288,-0.042539,-0.040752757,-0.04157284,0.0044405493,-0.09155993,0.026484761,-0.026184835,0.035600934,8.472938e-05,-0.06629914,-0.048704207,0.02387439,-0.029475033,-2.0617653e-08,0.015055337,0.0011971138,0.070963226,-0.039197452,-0.052942798,0.029767018,0.014900642,0.08412353,0.07047293,0.010413615,0.050296642,0.04346087,-0.028009703,-0.040622074,-0.01349242,-0.023999909,0.011794217,-0.0052333158,-0.04702478,-0.091974415,-0.06654719,-0.022548478,0.0022577445,-0.039672934,0.07844284,-0.090636514,0.008079016,0.014624743,0.012000832,0.0025270986,-9.875685e-05,-0.009988556,0.03485262,0.04870307,0.018535744,0.0071248524,-0.08253689,-0.04931337,-0.0053675333,0.05529188,-0.071502596,0.06900087,-0.13784023,-0.008725398,0.04078687,0.022509618,-0.014408595,0.020057872,-0.07515757,-0.02543197,0.02848483,0.057969254,-0.01401285,0.0033712701,-0.10456203,0.025623184,-0.006644682,0.0048590424,-0.001103225,-0.020542588,-0.017981267,-0.037815563,0.084890805,0.007410234 +1.2.1.61,Involved in the 4-nitrophenol degradation pathway.,384,1.0,0.036256786,-0.0024779076,-0.0020531458,-0.029034443,0.08521477,0.02746421,-0.0025426098,0.008835292,0.07765914,-0.043446653,-0.07453654,0.032218173,-0.079543956,0.010410882,-0.07542051,0.0809054,-0.08310323,0.0682195,-0.047902547,-0.036734995,-0.004856236,-0.036487523,-0.015593063,-0.058833964,-0.04955953,0.038351644,-0.004049676,-0.07591867,-0.013536585,-0.021132302,0.05427221,0.0460655,-0.014432002,-0.020391777,0.053270344,0.020669721,0.033040464,-0.038468096,0.019411592,-0.0038784354,0.026188638,-0.0434385,-0.06868183,0.045124028,0.018183723,0.0016198497,-0.053671744,-0.010023036,0.07876618,-0.08331568,-0.06577302,-0.027314208,0.039073277,0.028303187,0.029820314,0.05795308,-0.037609734,-0.044837877,-0.0075804456,0.10042877,0.08747691,-0.04549724,0.013607713,-0.048416857,0.009018992,0.076165825,0.044600327,-0.022068016,0.003892225,0.024827437,-0.07145864,-0.04958112,-0.004650983,-0.046782233,-0.023845337,0.033355348,0.05456763,-0.011422959,0.021240048,-0.08285048,0.06535611,0.10903519,0.07045995,0.02455826,0.026013426,-0.034091443,-0.032210734,-0.01728408,-0.016161725,0.11594051,-0.06295719,-0.006667385,0.09924313,0.0065887617,-0.048861038,0.08249943,-0.017631028,-0.039798815,0.038160212,0.0073862295,-0.013434003,0.025167773,-0.039482813,-0.051641986,-0.07631977,0.06884045,0.00023127867,0.097076006,0.027901199,0.0747104,0.022473391,-0.009415941,-0.0058658603,0.059483446,-0.011638493,0.034049146,0.025191097,0.03354171,-0.06866025,0.023601392,-0.04708759,-0.014327318,0.0283823,-0.0067407712,-0.10056939,0.07700515,0.08259238,-1.3373192e-33,0.07536231,-0.013684179,0.019759802,0.01869599,0.04215537,-0.011883284,-0.10989723,-0.010364033,0.04047781,-0.06278603,0.015627202,-0.08938733,-0.07883919,-0.068976216,-0.004777323,0.036678437,-0.063255645,0.080061816,0.052855406,0.0028992686,-0.0299227,0.004702924,-0.11077494,-0.01654899,0.0006129868,0.056668844,-0.05064876,-0.019733654,0.0030561592,-0.035775818,-0.027377877,-0.05057138,-0.044953085,-0.008068494,0.04099951,-0.032083,0.023940152,0.01696362,-0.005576218,0.08176237,-0.041687638,0.022097986,0.041507956,-0.029153246,0.059939366,0.0007808985,-0.036840897,0.050001957,0.029464796,0.0381018,-0.05036421,-0.047849495,0.056364875,0.0054892967,-0.033116173,-0.031472787,-0.0030384227,-0.023782715,0.017704584,-0.12737066,-0.013443277,0.027439374,-0.023942156,-0.015886534,0.13339633,0.022949902,-0.06394531,-0.017393943,-0.016111722,0.05963791,-0.050126947,0.0022016251,0.023655748,0.008211916,0.05296694,-0.0726098,-0.081946634,0.04832417,0.016939605,0.059112478,-0.030015998,0.06056117,-0.00024731897,-0.03603581,-0.006654148,0.0667944,0.030565334,-0.026962291,0.060912564,-0.0732353,0.045479078,-0.08862455,-0.055357102,-0.018159011,-0.017430022,7.6259273e-34,0.057982758,-0.026716132,-2.5446382e-06,0.02797418,-0.045271885,-0.0041047563,-0.07835868,0.0124182245,-0.002216515,0.03976816,0.070363216,0.004380635,0.037823964,0.007855021,0.024590386,-0.047458697,0.031039942,0.03307205,-0.08826933,-0.041691236,0.009670251,0.019733993,-0.00826902,0.07238424,0.010614174,0.018033022,0.04405489,-0.035320092,0.10205777,0.048693992,0.0511039,0.08189974,-0.07529578,0.0014621185,0.1019275,-0.036830526,-0.073334776,0.003517377,-0.044907693,-0.046720274,0.034066718,0.042956695,0.025130793,-0.012817007,-0.03167348,0.056135185,-0.081066236,0.041585226,0.027861398,-0.01821184,0.053907648,0.0411552,-0.12984328,0.061889526,-0.0076822145,0.041295122,0.073345214,-0.012863762,-0.027155684,-0.011840645,-0.09333322,-0.03686457,0.086383864,0.010226812,0.022636473,0.0067341533,-0.037850507,0.18397827,6.4755164e-05,-0.039195847,0.028779011,0.044802945,0.08874864,0.07493827,-0.030642444,-0.04929748,-0.013053165,-0.06636688,-0.017119002,-0.021700565,-0.030441202,-0.041835207,-0.08141954,-0.09412781,-0.03410474,-0.09023288,-0.010966512,0.08902652,0.012450436,0.0145259295,0.056230757,-0.039177027,-0.1438162,0.01992221,-0.09585553,-1.9625324e-08,0.06301884,0.011679656,0.0615891,0.045601625,-0.05230758,-0.023526829,0.061902236,0.11282252,0.11739561,-0.00027892648,-0.016327731,0.042033724,-0.020431519,-0.0362073,-0.0015125095,0.006193839,0.0010490927,-0.0713875,0.012012173,0.005083513,-0.08155561,-0.053850215,-0.062112622,0.025629105,0.017352423,-0.06909536,0.08312248,0.03342994,0.07383356,-0.096916094,0.037815433,0.019697133,0.04759054,0.03374312,-0.04174273,-0.006746484,0.03340723,0.0033835848,-0.038156033,0.048423197,-0.10414201,-0.019793749,-0.08887775,-0.0054515805,-0.019076146,-0.0065024327,-0.0049394,0.05372353,-0.027793849,0.03929818,-0.029808817,-0.041236263,0.010446503,0.01742118,-0.10838708,-0.005475921,0.07246206,0.045701273,0.034278084,-0.06713546,-0.010288052,-0.010479437,0.060083956,0.013889377 +1.2.1.62,Involved in the toluene-4-sulfonate degradation pathway.,384,1.0,-0.018575704,-0.043623064,-0.05637362,-0.016943889,0.08155088,0.02691653,0.0033867173,-0.038913347,0.030667458,0.018270832,-0.053656455,0.056162912,-0.022326559,0.0136893885,-0.13435803,0.08199693,-0.06577673,0.023982663,-0.012691922,-0.037382815,0.03137322,-0.04544988,-0.022813702,-0.049357858,0.04121343,0.037087277,-0.024602374,-0.11605322,-0.091988385,-0.02034044,0.034498848,0.07803912,-0.063481845,-0.008147063,-0.035196107,0.15300812,0.023361031,-0.04911043,0.0135246245,-0.046870496,-0.0037791785,0.053357445,-0.082522936,-0.020501489,0.030704768,0.014348002,-0.06243957,-0.02730917,0.05081513,-0.095361345,0.009162957,0.026723506,0.01357899,-0.053737316,-0.009745135,0.005316962,0.025924103,0.061370805,-0.027797125,0.0077189934,0.02830517,-0.06347389,-0.00250312,-0.027406873,0.0072234645,-0.020118022,0.08711462,-0.010342236,-0.004048182,0.019328084,-0.14119424,0.023178052,-0.036205024,0.020736177,0.041455362,0.111164585,0.04983393,-0.031192597,0.046536826,-0.078705505,0.07627637,0.043109965,0.03571018,0.0030064716,0.024727687,-0.01767424,0.021344386,-0.09738235,0.067628466,0.06271721,-0.006991167,0.04877283,0.05384028,0.018919457,-0.040509287,0.04712942,0.044142917,0.016344154,0.010772946,-0.032461237,0.012735411,-0.041016966,-0.104196645,-0.09191778,-0.044586096,0.0016545884,0.01568302,0.054094277,0.05597613,0.04584135,-0.016683944,0.041217275,0.08536838,0.010133515,-0.04930828,0.054775707,-0.011299115,-0.010643958,-0.08919925,0.0019640028,-0.06510997,0.048469003,-0.052148625,0.02204525,-0.043932855,-0.032676667,-0.01174127,-1.8496771e-33,0.09270662,0.08677524,0.10420046,0.011881574,-0.0608968,-0.05430018,-0.06436994,0.03983576,0.017600976,-0.01335914,-0.024641031,-0.10823279,-0.04783667,-0.06398286,-0.04832206,-0.017556727,0.021015251,0.003913135,0.03173035,-0.05226096,-0.19139048,0.024768047,-0.07974063,-0.029223125,0.099450804,0.03607985,0.057933733,-0.06087996,-0.03820697,-0.028141014,0.020854745,-0.06296652,-0.077145666,-0.00053869514,0.04145409,0.001466126,0.002651435,0.05121083,-0.015051209,-0.0142875165,0.029983712,-0.0026375907,0.0431527,0.0004189625,0.0153802065,-0.012767212,-0.017651534,0.062556215,0.052775547,0.035304897,-0.06430678,-0.058014315,0.09935345,0.0058839265,-0.08272707,0.03271825,0.0002017553,-0.06578809,0.042152222,0.02327652,0.0072898855,0.06533943,-0.11261574,-0.012321785,0.028151706,0.0029984924,-0.04725206,0.032996684,-0.048733372,0.002614008,-0.06779195,-0.024705674,0.016488926,0.004150352,0.019222748,0.01698242,-0.03193559,0.028128041,0.034801126,-0.013790082,0.009674147,-0.06457013,-0.013414899,0.029176755,-0.09361323,0.040072843,0.035981614,-0.0049184705,0.08109186,0.05634906,0.07274561,-0.05704718,-0.01890774,0.005898996,0.036865074,2.2525936e-35,0.061802577,0.030722499,-0.028277555,-0.04660405,-0.06738669,0.0024847656,0.003167295,0.025975578,-0.024499314,0.0050527845,0.055295058,-0.035757132,0.023452865,-0.12953669,-0.016449928,0.030777719,0.049932275,0.0032137302,-0.053765196,-0.019159589,-0.031003421,0.08274837,-0.020621808,0.020750934,-0.045842573,0.017253628,0.08486958,-0.0017917383,0.082290374,0.030702662,0.09815456,-0.026676152,-0.008650205,0.0047589806,0.035544418,-0.054557275,-0.043931045,0.017100096,-0.043845765,0.008282563,-0.042568956,-0.012350636,0.031767864,-0.0028298476,0.046924233,0.030236838,-0.075780645,0.014688405,0.06114522,-0.027886154,0.06487643,-0.0008210741,-0.02071236,-0.016082434,0.030124826,0.020572161,0.012835569,-0.055998344,-0.067287475,-0.018693069,-0.031726096,0.020913428,0.07570616,-0.016812928,-0.008963778,0.04853281,-0.0926103,0.047208253,-0.010043094,-0.04694792,0.041854624,-0.0077796453,0.06732745,-0.0038647945,-0.0799197,-0.041549142,-0.049216807,0.046071287,-0.037607767,0.035163283,0.019384613,0.05036686,-0.0017961315,-0.08575337,0.00039121014,-0.06580277,-0.027449856,0.05950364,0.028123107,0.00044757317,-0.0062865554,-0.05527732,-0.10068711,0.040239852,-0.01697141,-1.887094e-08,-0.00041803287,0.013328249,0.073675625,0.010953084,-0.08499577,0.035225533,0.14206322,0.116390616,0.05919604,-0.03987961,-0.029397795,0.0652295,0.032758024,-0.024314266,0.069509104,0.0147491265,-0.04153579,-0.0077247904,0.008420478,0.016025318,-0.08647449,-0.09738481,-0.11469795,0.01282514,0.09642234,-0.028796472,0.10228676,0.011925426,0.04518215,-0.0682227,0.038759574,0.0074255234,-0.012827093,-0.0103973,-0.005401008,0.0082786195,-0.029598398,-0.024948478,0.05844962,0.106422916,-0.061523292,0.097900875,-0.057619687,0.058644325,0.01403766,0.02262782,0.027293928,0.05968967,0.013996641,0.027463572,0.0045692073,0.036927752,-0.04681782,-0.06326808,-0.07245688,-0.009448682,0.077049345,0.045925546,0.052112866,-0.05044096,0.03504163,-0.077873364,0.073650554,0.02011891 +1.2.1.63,Last step in the cyclohexanol degradation pathway in Acinetobacter sp.,384,0.99999994,-0.08853434,-0.035923608,-0.06804315,0.052029345,-0.0067508975,0.03955292,-0.02494952,0.032748,0.01087759,0.01029049,-0.016057812,-0.023400962,0.056678623,0.011079858,-0.10297658,0.093146436,-0.059182975,0.0013027274,-0.002049229,-0.054714646,0.0058837538,0.044416998,-0.06544787,-0.05655654,0.019076614,-0.00028583355,-0.027113937,-0.019011162,-0.07949215,-0.014492859,0.031363595,0.0010355904,0.04712232,-0.013580068,0.1637797,0.05036668,0.010809783,-0.08111146,0.16895486,-0.03243597,0.015946439,0.07916286,-0.045741275,0.05481316,0.0039025052,0.04838408,0.039943516,0.008850073,0.041754313,-0.043661322,0.015710117,0.042487297,-0.0273115,0.03826061,-0.02242855,0.051224127,-0.06494327,-0.055803373,0.026299218,0.035702836,0.015530498,-0.0020797413,-0.04532154,0.043111525,-0.020095445,-0.05614662,0.034130782,-0.054274376,0.00809456,0.056276392,-0.11814394,-0.041529186,-0.010246931,0.0073264893,0.026917662,0.015573273,0.020598266,-0.08441734,-0.064589,-0.045237027,-0.0153992735,-0.029514952,0.051153142,0.016051866,0.014366743,-0.09700879,0.062216304,-0.031737566,-0.026225759,0.06669798,0.03553534,0.039784253,0.09488476,-0.071851864,-0.0037058613,0.023324965,0.108110294,-0.0005043372,0.006796408,-0.001548244,-0.07378938,0.05510151,0.036806364,-0.064808294,-0.017610952,-0.06295719,-0.0031163765,0.10828837,0.0457706,0.025960336,-0.058424346,-0.02338294,-0.031955056,-0.032209773,0.045388643,0.04396161,0.038382746,0.030763302,-0.057245493,0.047393072,-0.06450846,-0.044275064,0.0043073697,0.075446546,-0.028064633,0.029877262,-0.021047063,1.4057401e-33,0.01623629,-0.0570639,0.007982487,-0.07250651,0.043287814,-0.057745494,-0.023982564,-0.0016633595,0.07488039,-0.03046714,-0.0378355,-0.081275925,0.03362931,-0.071366176,-0.09910308,0.040592343,-0.1021471,-0.0060281074,0.010118273,0.04592271,-0.006578152,0.018267842,0.0607058,0.02784905,0.013756486,0.02111993,0.016143939,0.03855754,-0.040566858,-0.0044619734,-0.038386684,-0.013476812,-0.10336144,-0.055755697,0.084936544,0.0058098407,0.0058659017,-0.008227835,0.014216232,0.13059951,-0.07979395,-0.023800377,-0.0018243445,-0.025607096,0.079049,0.002896356,-0.07280247,0.091503724,-0.026267227,0.047508735,0.019548198,-0.064246826,0.039588537,-0.013099009,-0.032701463,-0.01225674,-0.045741964,0.029333437,0.04800533,-0.07210681,0.07145307,0.07197554,-0.053251535,0.03821794,-0.04899533,0.036727626,-0.067226246,0.008463848,0.0062425565,0.06620336,-0.06359743,0.002326506,0.055320773,0.025222987,0.09428943,-0.005935424,-0.07202883,0.042696785,0.06564508,0.03698806,-0.013446787,-0.060451347,0.025695875,-0.013753171,0.023438303,-0.04100643,0.005915531,-0.018850928,0.030530998,-0.015931107,0.09298447,0.017167205,-0.0415254,0.029022455,0.016442155,-2.7353226e-33,0.144898,-0.040208645,-0.0023606347,-0.039151922,-0.045177724,-0.015151474,-0.07154523,0.0766433,-0.018620891,-0.029456276,0.06537214,0.051415175,-0.032541327,-0.03219392,-0.022562636,-0.04534204,0.041367665,0.041137177,-0.08247701,0.023315737,-0.022465989,0.00020927069,0.032227144,-0.06998593,0.01501837,-0.03785418,-0.06445833,0.059316978,0.039600093,0.029276531,-0.039352126,0.048172865,-0.010192053,-0.07647146,-0.08016808,-0.0015581604,-0.06967817,-0.036470924,-0.023907728,0.019010644,0.06869471,-0.025891228,-0.057170644,0.004637262,0.079981245,0.059990007,-0.033415917,-0.03452347,0.020615973,-0.07479205,0.056496467,-0.0458115,-0.0057244557,-0.018497279,0.003124052,0.11204461,0.04375835,0.014071046,0.03784306,-0.0040631345,-0.00029487332,-0.037460014,0.08975002,0.044398814,0.069521226,0.040713694,0.04146817,0.16291855,-0.01905011,-0.0033204027,0.029701661,0.037988476,0.01143424,-0.019374046,-0.008543915,0.006381492,-0.051252313,-0.052749794,-0.067678764,0.017508112,-0.047226332,0.005210829,-0.084117204,0.001699848,-0.030410064,0.033294916,-0.035818033,0.024286162,-0.05592487,0.0028586984,-0.037040055,-0.028953869,-0.011248529,0.05665668,-0.00920024,-2.2724702e-08,-0.0030010517,0.048035163,0.045897383,-0.011809015,0.08556218,0.09716874,-0.0042864927,0.07869146,0.10444724,-0.073573165,-0.005191931,0.057838164,-0.00095333037,0.008863029,0.0066630538,0.025952546,-0.08076761,-0.06902003,0.06483187,0.039280936,-0.15150847,-0.051221974,-0.027335536,0.050096583,0.042278055,-0.050631,0.06205897,0.03004255,-0.028352432,-0.057691764,-0.010657966,-0.025150051,0.018833889,0.020620566,-0.022563666,-0.033503134,0.0023344427,-0.09345247,-0.0069080316,0.040153246,-0.08756628,0.12794848,-0.08201629,0.007700578,0.061848383,0.01985311,0.050849237,0.011461682,-0.06939542,-0.05472873,0.022165576,-0.02368508,-0.079406954,-0.013833283,0.001626843,0.01776685,0.027714679,-0.05554178,-0.07309703,0.0032180923,-0.07195864,-0.033472627,0.08743319,-0.0026216274 +1.2.1.64,"The bacterial enzyme (characterized from an unidentified denitrifying bacterium) is involved in an anaerobic toluene degradation pathway. The plant enzyme is involved in formation of 4-hydroxybenzoate, a cell wall-bound phenolic acid that plays a major role in plant defense against pathogens. cf. EC 1.2.1.96, 4-hydroxybenzaldehyde dehydrogenase (NADP+).",384,1.0,-0.056714304,0.027755897,-0.06029239,-0.024399294,0.111803845,0.10127573,-0.08823265,0.019148184,0.014894753,0.033325624,0.0008230267,-0.045815818,-0.019163055,0.05638688,-0.12979169,0.07881849,-0.07400541,0.022436567,-0.006792087,-0.031922042,-0.012499582,0.059991118,-0.028164005,-0.0072200545,0.06409692,-0.029090602,0.00084090134,-0.0094500445,-0.083028264,-0.033870343,-0.0015696959,0.07326346,0.035389535,-0.033181727,0.022000805,0.13073364,0.027630454,-0.07631307,0.103972755,0.0028188867,0.0040286356,0.028631115,-0.02211593,-0.022934666,0.016444994,0.024304891,0.011405172,0.07252093,0.025748363,-0.12250155,-0.018920269,0.052741073,0.038883798,-0.01669649,-0.034104154,-0.05107274,0.08250805,0.003688878,-0.06545011,0.0075359275,0.0708874,-0.071098536,-0.018110773,0.033377364,-0.010743031,-0.07925555,0.024576737,-0.041340202,0.0071135573,0.0013817447,-0.10793592,-0.07497566,-0.0242079,0.019131372,-0.010563516,0.028602025,-0.011285255,-0.025350822,0.054606963,-0.10662092,0.086810775,0.032611374,0.004622242,0.062331006,0.042819105,-0.04020603,0.03356332,0.0068081394,0.042395003,0.0376249,-0.026361935,-0.0021758056,0.042379856,0.025313739,-0.13690837,0.05735928,0.059967276,-0.027235335,0.02598182,-0.04238755,0.025282096,-0.0012426964,-0.045488894,-0.07240031,-0.014738993,-0.017473476,-0.0022854796,0.07358482,0.033918496,0.017182853,-0.02140251,0.00021323141,0.024255142,0.0043888786,-0.0018502532,0.046696685,0.078396715,-0.040548027,-0.0737523,-0.012194597,0.013228008,-0.06812782,0.014570638,0.030392833,-0.030888993,0.001995217,-0.079410344,2.4845748e-33,0.107165836,0.015626313,-0.05959526,-0.0022758879,0.033809062,-0.04710277,-0.05851657,0.045261342,-0.03738611,-0.04235874,-0.083575696,-0.09185656,0.04076592,-0.013519755,-0.03841834,0.008002525,-0.08855951,-0.013670061,0.006980357,0.057361927,-0.09279977,0.035634484,-0.09331848,0.013142112,0.080814414,0.021925358,0.022051424,-0.03263886,-0.020038128,-0.035008267,0.03345398,-0.09742413,-0.11872691,-0.0012673676,0.06256311,0.0005819629,-0.036542367,-0.0063598985,-0.031947713,0.032874748,-0.029794201,0.10305332,0.019904168,-0.029761912,0.071721606,0.0040476616,-0.046377644,0.08357573,0.028570568,0.07447928,0.029981997,-0.0018999667,0.13781463,-0.07640372,-0.03328956,0.055388477,0.009877324,0.031587295,0.030076694,0.047477335,0.027911989,0.02133087,-0.09084149,0.07814808,-0.0037968175,-0.026201546,0.013139635,-0.022298804,0.06832183,0.038182873,-0.11754132,-0.009436289,0.068816975,0.055074386,-0.029787114,-0.017817391,-0.061219726,-0.029889649,0.032429475,-0.03262357,-0.0125684375,-0.062385976,0.04557307,-0.040961925,-0.056864563,0.045321252,-0.019163268,0.021768102,-0.0116904685,-0.020361999,0.1171016,-0.08039558,0.007888094,0.008792517,0.042703927,-2.795671e-33,0.08476416,0.004541762,-0.0145817585,-0.07887735,-0.044815745,0.046786126,-0.038738303,-0.026284302,0.0013900284,0.012288612,0.07108229,-0.0038800582,0.06718336,0.005747623,0.030333987,-0.0111791305,0.02437877,0.027939904,-0.114357695,-0.04305214,-0.028629318,0.058324277,0.026858935,-0.05106188,-0.040603295,0.0352857,-0.03125956,0.05646713,0.027434496,0.029793665,0.025261756,0.008179645,-0.054030854,-0.022411497,0.0145920925,0.009694871,-0.079845704,-0.024708116,0.0075368495,0.033742733,0.04038283,0.045191433,-0.05575324,0.04682789,0.015917832,0.023757668,-0.10709525,0.034423955,0.022982817,-0.04996727,0.002390857,0.014758183,0.0017433148,-0.00040944054,0.010654197,0.008312494,0.027426355,0.0010706079,-0.044523876,0.014878347,-0.050906148,-0.013732224,0.086405866,0.07377709,-0.018941887,0.07328745,-0.049356986,0.09828424,0.020779127,-0.021563658,0.05521742,0.05858402,0.03837753,0.0871567,-0.119817846,-0.05606201,-0.04452987,-0.06331097,-0.030370444,0.0361911,0.03948804,0.00070843025,-0.014183015,-0.0423011,-0.023166023,-0.0899839,-0.023055015,0.076636046,0.0040107137,0.036106598,0.03184767,-0.0026797415,-0.06818909,0.006304111,0.023830168,-3.9242217e-08,0.02185677,-0.026080094,0.07799378,-0.08827526,-0.020344205,0.008361581,0.058183808,0.054199334,0.11115738,-0.047742683,-0.0010019318,0.06688554,-0.014407479,0.020566955,0.03916621,0.010423831,-0.012842316,-0.020449355,-0.0572987,0.010062948,-0.072363034,-0.0385634,-0.14118874,0.065949485,0.049896944,-0.021876378,-0.01570366,0.0349076,0.08264907,-0.04167269,-0.014428829,0.05075842,0.011688766,0.0023182284,-0.086318664,0.049459986,-0.023573618,-0.05578496,-0.016322039,0.074297585,0.016594404,-0.04644813,-0.09255681,0.0074515427,0.057593457,0.035251115,0.0019386797,0.007503327,-0.013377856,-0.009931521,0.032808937,-0.011109268,0.01843007,-0.036297284,-0.098744504,0.030696735,0.009114418,-0.020299084,0.007150636,-0.046542387,-0.044253845,0.016784774,0.19244099,-0.022634923 +1.2.1.65,Involved in the naphthalene degradation pathway in some bacteria.,384,1.0,-0.014659591,0.062495537,-0.035215054,-0.021206222,0.013043728,0.043316867,-0.038247388,-0.027999701,0.06604447,-0.037135873,-0.06270722,0.00076765934,0.044329222,0.07522157,-0.0038661682,0.02045562,-0.12949297,0.029996786,-0.008714901,0.0019391265,0.014729978,0.113597214,0.01057322,-0.040924057,0.02764837,-0.008798779,0.041909635,-0.090997435,-0.029828316,-0.055815183,0.025952563,-0.004015406,-0.0149376625,-0.043970216,0.048962355,0.072808355,-0.01070272,0.03387971,0.092803165,0.032925613,0.010255091,0.009706159,-0.06718772,-0.067230955,-0.024847975,0.07331992,-0.051276006,0.029069504,0.03776805,0.009966409,-0.07317167,-0.0023088872,-0.02537284,0.063245274,0.019861098,-0.052620154,0.033022076,0.035119303,-0.07414324,-0.0118513405,0.046589434,-0.009852344,0.051101755,-0.018607032,-0.06117413,-0.04945169,0.057753388,-0.019767348,0.029874492,0.043810446,-0.09664991,-0.06770224,0.027989564,0.044530552,0.03470782,0.005514902,0.052652057,-0.098340616,-0.024158891,-0.059505302,0.08117076,-0.015635252,0.011050821,0.06933477,-1.544899e-05,-0.019017322,-0.020247815,-0.06480134,0.008192728,0.026369033,-0.009808363,0.018942079,-0.0006309346,-0.04163631,-0.020744747,-0.05600303,-0.0044300803,0.043844696,0.0038920771,-0.0069343583,-0.082983375,0.008425234,-0.08578021,-0.10513623,-0.053249873,-0.018640367,0.008003137,0.040319197,0.047093548,-0.030472621,0.05349386,0.046790022,0.058099154,-0.015834304,0.0027257155,0.018467678,0.011463858,-0.01620546,-0.14419894,0.0388897,-0.06785546,-0.114800476,0.00033517645,-0.001528738,-0.06538729,-0.008634179,-0.047138542,-2.5638252e-33,0.039928626,0.018713942,0.008410737,-0.026929157,0.013041557,-0.094071865,-0.015618205,-0.070895895,0.009096027,-0.07666607,-0.004034257,-0.075848185,-0.048675016,-0.031626604,-0.0015158454,0.050833054,-0.08615716,0.047705103,0.01253704,-0.052424014,-0.04873959,0.028056335,-0.010715426,-0.079474226,0.047730234,0.065609604,0.078910254,0.061075624,-0.10591921,-0.05700748,0.098966025,-0.028931394,-0.13481638,-0.003303915,0.13396847,-0.010546891,-0.010754527,0.055356555,-0.024478728,0.014400621,-0.08691323,0.03946514,-0.04914927,-0.046071332,-0.0021063383,-0.022819825,-0.016812,0.1852443,0.0584168,0.035467707,0.037291374,-0.08625042,0.10829904,-0.035847794,-0.061263837,-0.025376253,0.02841635,-0.08197314,0.05211462,0.04745263,0.04682297,-0.027430952,-0.035858158,-0.021447081,0.04813282,0.029131122,-0.08377207,0.032037593,0.048376117,0.03128567,0.0039753397,-0.0065778242,0.06000033,-0.031637065,0.0047172336,0.0010491227,-0.09644585,0.058569748,0.073613174,0.03786682,0.063783154,-0.034882657,-0.0026440753,-0.022466041,-0.046055518,-0.0037038308,0.0047078705,-0.016509911,0.018914752,0.04560536,-0.0016905001,-0.064051256,-0.06273084,-0.011363685,-0.0137572745,3.6981697e-34,0.102171496,-0.005896295,-0.06514084,-0.02333285,-0.005562499,0.039701164,0.016190186,0.08695931,-0.040862184,0.020548377,0.07009926,0.062310033,0.03495476,0.03129669,-0.0020029237,-0.047260918,0.061569154,-0.00486629,-0.061541237,-0.072081886,-0.0037662392,0.013627631,-0.12332327,0.052849505,-0.06327233,0.057258908,-0.059622243,0.08687506,0.03456148,-0.0072349454,0.06624601,0.009891621,-0.0381967,0.02249364,0.029649917,0.024048688,-0.0054832287,-0.0074585225,-0.017995056,-0.07259569,0.029477622,-0.026999544,0.008294455,-0.01627541,0.111356966,0.025638476,-0.04430693,-0.02368317,0.02589995,-0.016102321,0.013635476,0.020498589,-0.005323833,-0.010210009,-0.06147008,0.07675673,0.01797515,-0.015577572,0.042940125,-0.035460725,-0.03319493,-0.03582574,0.07038891,0.053818002,-0.05787475,-0.012626169,0.06541498,0.06401846,0.08338143,-0.014429603,-0.008441406,0.043395873,0.06372739,-0.027504107,-0.109183624,-0.04727626,-0.022833666,0.015347803,0.059427865,0.023586493,0.026328817,-0.041286483,-0.061737683,-0.09038034,0.029576134,0.0044784434,-0.0190289,0.013114431,0.023490084,-0.0046506813,-0.011633822,-0.05987627,-0.09655497,0.01243626,-0.015893104,-1.9910916e-08,0.06554958,0.0002670873,0.06594806,0.04138723,-0.004867255,-0.034934662,0.048860535,0.0909663,0.05321725,0.005504601,0.034318388,0.055077776,-0.003035827,-0.057800315,0.054483436,-0.007968309,-0.0616374,-0.004045695,0.0001817077,-0.023641478,-0.07031165,-0.01535542,-0.09032602,0.069146834,0.07762143,-0.038436167,0.056972567,0.01284899,0.01680673,-0.07721973,-0.004233018,0.036326535,0.0076711774,-0.02617611,-0.034409925,-0.019096397,-0.038392868,0.018235171,0.023151528,0.09301799,-0.05763601,0.0936433,-0.10853939,0.016676748,0.060855616,0.062222987,-0.0033080042,-0.011807289,-0.09960863,-0.020610763,0.051139593,-0.009722548,-0.030416744,0.0040664505,-0.13529089,0.045094863,-0.010656345,-0.022449471,0.031348456,0.024842884,0.011438519,-0.0132442545,0.14321968,0.015144445 +1.2.1.66,The S-formylmycothiol formed hydrolyses to mycothiol and formate.,384,1.0,0.047356702,-0.082993515,-0.03768654,-0.0035003005,0.063624054,0.002471259,-0.048747994,0.059129193,0.0014359015,-0.016538633,0.0384136,-0.0629894,0.024435956,0.030249089,-0.06864564,-0.025078163,-0.040981352,0.019243537,-0.038962603,-0.01465838,0.06535368,0.061981305,-0.029300652,0.06495301,0.075036295,-0.0141913565,0.019652732,0.03559826,-0.030013295,-0.10418102,-0.006542781,-0.043371443,0.07627203,-0.072118744,0.09423458,0.060005948,-0.029709164,0.037249032,0.088599995,-0.0472781,0.008364903,-0.12114611,0.06654214,-0.029761693,-0.02259795,0.004411762,-0.032668207,0.03486864,-0.03170558,-0.0032212613,-0.01592035,-0.08983941,-0.0726168,0.019789226,-0.026198957,0.040522747,0.04083926,-0.023733214,-0.07044264,0.10523373,-0.0005500152,0.005360915,-0.06268025,-0.019942703,-0.048385214,0.017531728,-0.033709187,-0.009473425,0.07927426,-0.021237357,-0.04265118,-0.0072993436,-0.06223496,0.08396469,-0.018208118,-0.020742558,0.005903542,-0.039839234,0.069405,0.03210714,0.011868216,0.02929872,0.037190054,0.021347588,0.03050549,-0.024732286,0.039927263,-0.0057793115,0.034894083,0.026824584,0.042644694,-0.053915024,-0.014733496,-0.0041125054,-0.044730585,0.038897596,0.098363526,0.009814388,0.035922818,-0.03861231,0.008803985,-0.08340661,-0.063282184,-0.09828133,0.0030444933,0.012750543,-0.010794205,0.031031102,0.059965167,-9.292299e-05,0.040306102,-0.03680839,-0.019075684,-0.03216893,0.011904185,0.03611206,0.05517637,0.049128823,-0.08441064,-0.007609397,-0.010721695,0.044661462,-0.037443984,-0.047476616,-0.07891693,-0.043241743,0.04039282,-2.9351915e-34,0.015523391,0.012294015,-0.029360555,0.044955615,0.020372458,-0.06535692,-0.100136325,0.018629374,-0.017091822,-0.03790093,-0.057104032,-0.026812362,-0.11290519,0.031739634,-0.09717825,0.008795767,-0.000810937,-0.030178037,-0.012256742,0.06672895,-0.02653919,0.064628825,-0.02597055,-0.038076412,0.012987419,-0.027595297,-0.022822738,-0.05999598,0.046656746,0.0052403673,0.0036747244,-0.06634932,-0.11230405,0.047613937,0.057875134,0.015565832,0.017656345,-0.078878544,0.052733433,0.036336873,0.0071163797,0.03274173,0.012867779,-0.037785042,0.002035983,0.07197782,-0.04494737,0.06691073,0.024024885,-0.028024845,0.04791126,0.007864599,0.07486686,0.050664004,-0.06511769,-0.039751824,0.036958113,-0.050124828,0.026435403,0.038423,-0.011330114,0.109741315,-0.0012049817,0.015660211,-0.021857055,-0.035379432,-0.022555698,0.016058814,0.03335743,-0.061199468,-0.0142636355,0.024784207,-0.017919388,-0.0060423445,0.03742562,-0.10274912,-0.012075222,0.07367088,0.019016508,0.044344995,0.036087353,-0.0005463172,-0.05732024,-0.024680775,-0.015814217,0.030558016,-0.01765361,0.018271472,0.0069214227,-0.0066245245,0.0028947382,-0.057161205,0.060891207,0.039191686,-0.008739383,-1.548765e-33,0.023689311,-0.11004464,0.05857157,0.0020604122,-0.022346586,0.046013843,0.009509388,0.06705538,0.06871715,0.036057156,0.022369757,0.0037596307,-0.048879456,-0.057444893,-0.05887171,0.012586214,0.028120328,0.08735916,0.051847555,-0.0668773,-0.06179835,0.11936071,-0.032876115,0.057631243,0.10421516,-0.031821143,0.015586516,0.050193552,0.060147364,0.12666513,0.05561872,-0.06959978,0.013457224,-0.11028903,-0.0659513,0.029634804,-0.08976387,-0.00077940634,0.02558719,-0.018742628,-0.03921584,0.044533078,0.06663311,0.07363632,0.03259509,0.05718678,-0.13269983,0.0016374531,0.032213777,-0.032047648,0.001980877,-0.064392515,-0.012167366,-0.029828116,-0.043233335,0.031154998,0.004942914,-0.026786098,-0.02733957,-0.05156286,-0.04873288,-0.011057192,-0.07074547,-0.047477674,0.025238413,0.0634472,-0.015920276,-0.006040746,0.09072907,-0.070199974,0.02836603,-0.026733503,0.051000893,0.08821979,0.058923606,0.00020599025,0.001844308,0.071499154,0.004784759,-0.02514243,0.06226622,0.06536489,0.01126831,-0.10323473,0.034049973,-0.14011855,0.078557014,0.112192415,-0.051250692,0.045328334,0.048699193,0.13562824,-0.032642018,0.08374184,0.08725758,-2.1719764e-08,0.06145481,-0.103360645,0.06427527,-0.062488478,-0.023095563,0.035757534,0.10475336,-0.018936709,0.11712043,-0.06529852,-0.053756967,0.04212193,-0.0046660677,-0.037653174,0.007524624,0.004589644,-0.011516054,0.024987305,-0.037474487,0.012840112,-0.047069456,-0.021123396,-0.041705742,-0.03025554,0.0011703793,0.022698753,0.038531814,0.035797138,-0.04907056,0.001665847,0.08119658,0.017027868,-0.051629666,0.024408026,-0.09887992,0.028599875,-0.12577954,-0.07197023,0.037560306,-0.01280319,-0.00033623184,-0.05556947,0.0073290393,-0.0011355932,-0.038080018,-0.06352685,-0.061001,0.043312084,0.009385165,0.02621896,0.012762587,-0.008826063,0.026272304,-0.033959687,-0.020270146,0.009595714,0.07237036,0.021535346,-0.031268943,-0.11162384,-0.016657922,0.01580825,0.12890352,-0.009291129 +1.2.1.68,"Also oxidizes other aromatic aldehydes, but not aliphatic aldehydes.",384,0.99999994,0.017816972,-0.07519011,-0.0073014265,0.059891902,0.09295047,0.008243569,-0.038739584,-0.057823062,0.07471807,-0.037556697,0.048609704,0.079604656,-0.009762537,0.01956289,-0.0146588255,0.06346847,-0.029941237,0.07964481,-0.055191614,0.013164844,-0.02974191,-0.024844207,0.028100956,0.027617216,0.038204245,0.014688003,-0.029277025,0.04991608,0.022873808,-0.0673406,0.04602723,0.05933404,-0.061149955,-0.054264832,-0.023597827,-0.012281315,-0.04612826,0.0380063,0.030053861,0.015106233,-0.024133163,-0.004324347,-0.045821913,-0.025754806,-0.000573516,-0.020048931,0.02386376,-0.0070323814,-0.08262077,-0.005052532,-0.008038513,0.045848515,-0.09393468,0.05183658,-0.005720176,-0.0051157027,-0.042590402,0.044029392,-0.06897395,0.008880134,-0.03824878,-0.01803115,-0.049180347,0.039603874,-0.06753597,-0.04543147,0.050500404,-0.0134422835,-0.01754771,-0.046111125,-0.060989413,-0.08561187,-0.010474567,0.06550061,0.034031447,0.008052692,-0.02610945,-0.072270565,0.042579602,0.029431855,-0.067788444,0.019599501,0.015247558,0.05241482,0.08322728,-0.04113819,-0.04807475,-0.06321602,-0.12118182,0.038063988,-0.02782716,0.022407262,0.021232571,-0.041478712,-0.0022405994,-0.0018881767,0.10477558,0.11855478,-0.027745847,-0.026453324,-0.04640948,0.035944015,-0.09826128,-0.10958507,-0.038651433,-0.013151572,0.047827527,0.05784701,0.010491989,-0.049337335,0.010112338,-0.0017600914,0.034975406,-0.048297334,-0.049493823,0.07148222,0.059554305,-0.045010637,-0.074632935,0.017131576,-0.033967897,-0.036123782,0.020409076,0.043079354,-0.05783566,-0.029624006,0.006708568,1.6337158e-33,0.020310288,-0.03946147,0.026726732,-0.012174405,0.047710042,0.005351094,-0.10247615,-0.0007024551,0.07921749,-0.020389797,0.021868305,-0.017437346,0.040314294,-0.015139169,0.05978589,0.0496629,-0.10132196,-0.019988101,0.030548407,-0.033385333,0.040345967,-0.016184332,-0.043232717,0.031144379,0.015411548,-0.025541611,0.031455506,-0.029056726,-0.083640575,-0.012879592,0.023298843,0.043572664,-0.1026758,0.014473901,-0.076089926,0.06249566,-0.07397654,-0.063924834,0.009578646,-0.011768129,-0.012383471,0.019328436,-0.022224741,-0.033807006,-0.018541653,-0.049870607,-0.06738087,0.11748564,0.06702856,0.017785296,0.05926276,-0.0012307203,0.06657359,0.023117837,-0.032462407,0.0737623,0.010233077,-0.05583459,0.01954707,0.05370983,-0.04084654,-0.023292286,-0.07936889,-0.034793586,-0.018992722,-0.0135750985,0.012793872,0.060977995,-0.02969038,0.012506433,-0.025546934,0.027099017,0.104555726,0.028828578,-0.04364598,0.007344234,-0.08832358,0.0119868135,0.118979245,0.04742331,0.015257009,-0.079215884,0.028635006,-0.03406499,-0.06047254,-0.011943012,0.022298187,0.09673597,0.031018909,-0.005159844,0.04688539,-0.06316702,-0.030752657,-0.031280216,-0.004187762,-4.0131722e-33,0.066924155,-0.046874683,-0.051986728,-0.016225284,0.0054192967,-0.023575833,0.010991809,-0.002053699,0.029473867,-0.03740302,0.05654111,0.027952163,-0.0118227815,0.0077143097,0.05267768,-0.040491246,-0.0045599407,0.04174628,0.019167205,-0.038308684,0.00037080143,0.054591168,-0.04007273,-0.0007775153,0.06914346,-0.016804827,-0.10692411,-0.03012918,0.09009087,0.06018652,0.009265562,0.015023753,-0.019652031,-0.0727904,0.02846846,0.022236401,-0.053898714,0.019793268,-0.11853892,0.046681788,0.040705193,-0.011515516,0.0752305,0.08338937,0.059090324,0.027187394,-0.10609884,-0.0518828,0.015196194,-0.030245524,0.08932,0.06634799,-0.09179706,0.018824244,0.059119605,0.07775891,-0.036455166,-0.075317405,0.028449854,-0.034465153,-0.07300714,0.0109447595,-0.028249536,-0.074784055,-0.0912763,0.010179308,-0.062571585,0.0402973,0.04891493,-0.029018816,0.10201152,-0.015199053,0.019832604,-0.039802328,-0.03230743,-0.06399249,0.048523173,0.03233877,-0.040159043,-0.009167093,0.055941183,-0.008782694,0.00570963,-0.04868371,-0.048366785,-0.022687986,-0.061854508,0.022640679,-0.024162691,0.035858765,-0.04607406,-0.0018967651,0.097715095,0.06591332,-0.011767021,-2.4053781e-08,-0.08140552,0.06554054,0.14232005,0.034083262,-0.09280402,0.0005520384,0.12877013,0.07696133,-0.022675272,-0.042417865,0.038226824,0.02285766,0.0633904,0.028988544,0.08753014,-0.040365428,-0.017335182,0.017550042,0.0035696058,-0.065234646,-0.120049775,0.005447858,-0.0124327745,0.07018877,-0.0130298305,0.008378984,0.039648134,-0.079859674,0.055012446,-0.029649964,0.00077050604,0.057326786,0.047992922,-0.02959402,-0.052909907,-0.006385037,0.039032463,-0.0682276,-0.051082168,-0.019496633,-0.03123486,-0.0776569,-0.059779402,0.03483254,0.10254426,-0.030198514,0.028200155,-0.0031889318,-0.019906143,0.0029728557,0.12055803,-0.0007290168,0.008486398,-0.05355919,-0.063699074,0.03630755,0.043592565,-0.030468795,0.067897014,-0.046338093,0.058620118,0.023248428,0.19314195,-0.0064027756 +1.2.1.69,The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.,384,0.99999994,0.04055687,-0.090238616,-0.13549618,0.013622817,0.014672527,0.05109688,-0.047107093,0.035852898,0.00765204,-0.062418714,0.0026161158,-0.0028727446,-0.05498643,0.017358465,-0.04717839,-0.0121956775,0.025957635,-0.040461574,0.014618834,-0.040634785,0.0362883,-0.040248882,-5.0417184e-05,-0.012239931,0.12914151,-0.02889954,-0.03281485,-0.021330746,-0.07105181,-0.064443894,0.021569273,-0.022970077,0.0057366933,-0.016292492,0.054867856,0.004720336,-0.008815124,-0.02730209,0.06872638,0.012055307,-0.057897255,0.032393266,0.006946409,-0.007210105,-0.017276794,-0.023832288,0.007048822,0.046605974,0.02068257,0.015470375,-0.037943505,-0.041853663,-0.059915833,0.0064821243,0.05000677,0.029008782,0.010339015,0.012056273,-0.025491452,0.035685662,0.021438738,-0.01785287,0.0239877,0.013487233,-0.03245311,-0.079948485,0.057942107,-0.028639738,0.049594145,0.015375623,-0.08393255,0.008653298,-0.010206002,-0.003227087,0.056426823,0.10544219,-0.09196786,0.00068859715,0.10731405,0.025096437,0.03070027,0.013935266,0.08630747,0.10362986,0.051440217,-0.032306403,0.01612071,0.02366156,-0.004926786,0.015420362,0.043144062,0.005284708,-0.021640478,-0.024620414,-0.086033896,-0.04195973,0.040140066,0.029383618,0.005813252,-0.01716989,-0.008584753,-0.0392416,0.0314977,-0.004925281,-0.04328817,0.023537977,-0.06415703,0.079771236,0.0638707,-0.052337207,-0.059604116,0.042707067,0.014350973,-0.02818291,-0.0077902214,0.05158262,0.053851485,-0.09583765,-0.07343793,-0.0023195515,0.03706973,0.01235852,0.08302945,0.059853304,0.044851363,0.04631436,-0.019052738,3.48826e-33,0.056906275,0.06674705,0.060088336,-0.06312138,0.06820012,-0.001897663,-0.10098064,-0.0018754621,-0.024785414,0.00031678236,-0.05680141,-0.050672557,0.031319384,-0.006861626,0.02488184,0.064642,-0.050967697,-0.06798715,0.046115592,-0.027658058,0.08732157,0.006302277,-0.021044696,0.012584442,0.0151541205,-0.017169941,-0.033816434,0.07332679,0.013061363,0.016772818,0.0037746418,-0.14351815,-0.10468318,-0.036656745,0.026634209,-0.051216163,-0.058365848,-0.1200152,0.030399157,-0.024486322,0.06274861,0.069810025,0.09371147,-0.019500757,0.014830954,0.0031626509,-0.03557617,0.060317773,-0.0018540969,0.05588265,0.021991875,-0.038831193,0.105855875,0.010790537,-0.07919092,0.109803274,0.045074586,0.03875385,0.060644124,0.075049706,-0.011562252,0.025025412,0.053534925,-0.037352066,-0.007253906,0.025105095,0.051429562,0.024108624,0.050572436,0.093442306,-0.034644023,-0.07158714,0.01736725,-0.006715015,-0.009324064,-0.06850111,-0.070328295,-0.008719633,0.011853688,-0.040358845,-0.04551763,-0.05402286,-0.0072652446,-0.049008396,-0.11257304,-0.017654898,-0.087652706,-0.030874042,0.016438993,0.035173994,0.021436188,0.0022316966,0.016598241,-0.0493326,0.04675549,-3.8510146e-33,0.08211995,-0.10967892,0.07980655,-0.029114245,-0.052998375,0.0577812,0.009162555,-0.030633915,0.046650514,-0.030752622,0.07763995,0.028082537,-0.026333073,-0.022702847,-0.037442096,0.0066411076,0.013838239,0.07864293,0.050439045,0.0036623105,-0.049141202,0.029685259,-0.027777376,-0.008390202,0.077867106,0.033222225,-0.012830009,-0.04793736,0.091485284,-0.022603652,-0.0011937348,0.019874232,-0.066676304,-0.09586787,-0.08407121,-0.04452223,-0.0375296,0.037218936,0.00231477,0.02142209,0.034177035,0.06296761,0.018314535,0.067602575,0.029083097,0.10254228,-0.13625404,-0.0038042753,0.035393614,-0.01840983,-0.025857577,0.047507495,-0.036621597,0.053858954,0.018922325,0.06466782,0.038183108,-0.094777845,-0.01779147,-0.0010758716,-0.031892307,-0.032340027,-0.041620042,-0.08431031,0.05659291,0.011469386,-0.023785764,0.04751583,0.096232034,-0.073777065,0.06828939,-0.019021628,-0.01257852,0.1314255,-0.01718798,0.0013041372,-0.025261108,0.043940727,0.050055496,0.008063646,0.04869222,-0.028321858,-0.012289089,0.014055722,-0.0053867036,-0.06735035,-0.014836206,0.14018457,0.030976053,0.042467557,-0.025971914,-0.026869468,0.03318125,0.0063356254,0.03903505,-2.6820986e-08,0.02802249,-0.06230341,0.03218686,-0.06869072,-0.034307804,-0.025049785,-0.030930076,0.033823762,-0.019107696,-0.027412832,-0.027469192,0.064271845,-0.030175705,0.013771756,-0.10187831,0.0010100445,-0.01710137,-0.019865515,-0.030739425,0.06769284,-0.12961708,0.019567417,-0.12635253,0.05612237,0.021631487,-0.04634176,-0.0022590975,0.058190238,0.032342892,0.044827312,-0.0611352,0.06895329,-0.0047933594,-0.031134382,-0.091076605,0.011452287,-0.037775505,-0.03596008,-0.012029335,-0.0061496547,0.02989919,-0.05762223,-0.009315515,-0.03560583,-0.024107998,0.009705461,0.053654786,-0.032797918,-0.03678277,-0.029489728,0.055228777,0.0035161574,-0.018281851,-0.0022309537,-0.08778859,0.026238134,-0.023795456,-0.09168529,-0.0093250405,-0.08482793,0.024817964,-0.12169531,0.18726744,-0.028283166 +1.2.1.70,"This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway. The route shown in the diagram is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the alpha-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.",384,1.0,-0.091637805,-0.049512625,-0.11534433,-0.04141194,0.086283594,0.044388086,-0.07392646,0.036557615,0.048806224,0.031041065,0.056194454,-0.06080627,-0.023332635,0.013211614,-0.023498055,-0.013143948,-0.11176683,-0.009401459,-0.049137708,-0.062339704,0.013304337,0.0409506,-0.0047267913,-0.022898609,-0.011330988,-0.06393633,0.005517058,-0.010329045,-0.03087868,-0.06439725,-0.00948497,-0.03276682,-0.05608094,-0.070050575,0.03325337,0.05827654,-0.08051021,-0.13201864,0.055384457,0.005097968,0.065626,0.024037367,-0.091898344,-0.016928906,-0.06211248,-0.001151565,0.037913874,0.02598253,-0.019394225,-0.032309517,0.0043373113,-0.06587638,-0.034971032,-0.04500328,-0.011673544,0.037092533,0.003843276,-0.06269338,0.036163833,-0.0015796849,-0.00040474383,-0.0027943796,0.0014646837,-0.0791722,-0.018055197,-0.022270195,-0.010306926,-0.06864444,0.014665337,-0.044846203,-0.062465284,-0.10741549,0.056718744,0.11509594,-0.06466158,0.031202625,0.0045171427,-0.040862788,0.035882834,-0.034964535,2.8178452e-05,0.027275644,-0.036395237,0.042053413,0.023118602,-0.057396982,0.010670922,0.05376035,0.022676554,0.0398816,0.11348649,0.01491617,0.02975085,-0.04465413,-0.06915883,0.03597204,-0.03172875,-0.0077208616,0.04935414,-0.053494733,-0.015108276,0.03298967,0.017918251,-0.06866176,0.0022655951,-0.009584664,0.0316822,0.111394905,0.028953971,-0.0069118417,-0.050102632,-0.06301109,-0.026946412,-0.047622964,0.022714011,0.07000113,0.01967577,-0.022978187,0.0068355,-0.030868609,0.0468191,-0.013395112,0.10213844,0.055820696,-0.052695777,0.036646448,-0.11628758,2.3285019e-33,0.07300246,-0.02793406,0.029286344,0.05561518,0.069406606,0.016784227,-0.06985117,-0.032542575,0.044317603,-0.09219322,-0.14316638,-0.043198694,-0.012637157,-0.046578303,0.009863009,-0.0312671,-0.0412103,-0.0011035482,-0.028589156,0.046898086,0.0115335155,0.049819756,-0.0012232964,-0.018466122,0.08279551,0.055748556,-0.02198065,-0.03164218,0.06292053,-0.012883328,-0.015216831,-0.06306358,-0.13437246,0.031417787,0.11246381,-0.0047139116,0.02483597,0.018605301,0.014076665,0.05076826,0.031245485,-0.006331672,0.02623583,0.00482774,0.07957926,0.022586232,-0.046564855,0.08721355,-0.0025718792,0.02055511,0.07227653,-0.0042037857,0.112749726,-0.021397073,-0.029690292,0.028813334,-0.021245617,0.035092622,0.06897565,0.044039916,0.029829027,0.05465493,-0.027382659,0.05925301,0.025422733,0.0760798,-0.071194515,-0.042718578,0.050477766,0.031953715,-0.03710292,-0.014915911,0.11519342,0.09708186,0.011722559,3.6763864e-05,-0.052069113,0.007024068,-0.028328203,-0.02485121,-0.056277066,0.014132197,0.00060208107,0.0333407,0.028469637,0.02490295,-0.035574183,-0.0073771146,0.019298399,0.024853736,0.12363132,-0.038730174,-0.047184844,0.025316775,-0.09350893,-2.6362228e-33,0.117997386,-0.1216783,0.007838804,-0.10515777,-0.07948683,0.054969072,-0.0245772,-0.086914785,0.029436123,0.031819046,0.09316839,0.04569426,-0.0037605567,-0.014210411,0.02677457,-0.03367593,0.010678383,0.09400712,-0.04775286,-0.057986237,0.012779928,0.016219351,-0.012766755,-0.024733836,0.06318752,-0.00067944336,0.013091412,0.043119762,0.0200583,-0.0046042427,-0.04244904,0.003055638,0.018294454,-0.0346724,-0.02664457,0.009643161,-0.00824094,-0.009128874,0.0063369945,-0.041166276,0.0153522715,0.03962168,0.037449107,0.034468018,0.0074318484,0.014240304,-0.060577925,-0.00055720145,-0.08554946,0.027303675,0.05468843,-0.06661028,0.004644122,-0.033121202,-0.029390821,0.011871547,0.060659926,0.01173576,0.028086543,0.037835076,0.022386208,-0.011146233,0.06988256,-0.009244146,0.037931927,0.04157095,0.020851744,0.09606385,0.019543618,0.0005480696,0.03315233,-0.017539136,0.04819189,0.027202085,0.007988594,0.04032923,0.013814171,-0.0038381717,0.033155076,-0.07850511,-0.05514211,-0.036949452,-0.0071171173,-0.015625065,-0.0206918,-0.07559351,0.049119033,0.11528224,0.093005724,0.064405486,-0.030159427,-0.05362267,-0.032067325,0.11587454,0.086317405,-4.1743032e-08,-0.013793753,0.032140326,0.021825647,-0.022646606,0.09034277,0.045823254,-0.02724871,-0.022920655,0.111671396,-0.05062124,0.019284459,0.070194565,-0.030511972,-0.01232172,-0.023541892,0.08773374,-0.02284586,0.048850723,0.025594292,0.024241477,-0.09373373,0.028534774,-0.11280597,0.0222771,0.029553536,-0.082132705,-0.02020629,0.10937901,-0.026015146,-0.10007816,-0.03551405,0.016541852,-0.018114807,-0.029950934,-0.031951137,0.07995714,-0.015541529,-0.042386763,-0.058388207,0.055117857,-0.018442607,-0.059939682,-0.039530527,-0.025162753,0.0058267564,0.0064280573,-0.05316058,0.05083488,0.0049017267,0.0037611679,-0.027341627,0.03406589,0.038811598,-0.06060758,-0.12054785,-0.012296242,-0.030473389,-0.05443856,-0.044939704,0.016421493,0.01381115,0.050388705,0.1437129,0.03796166 +1.2.2.2,A flavoprotein requiring thiamine diphosphate.,384,1.0,-0.05101624,-0.022402797,-0.091804154,0.045107882,0.026322562,-0.0018554198,0.07622619,0.0744535,-0.027045034,-0.012865339,-0.0080507565,-0.0028862343,-0.0063542207,0.033899035,-0.072019845,0.01685587,0.02321499,-0.05248558,-0.029162707,-0.028613204,-0.042057402,0.08084527,-0.005613802,-0.015509775,-0.026608605,0.04068981,0.04035446,-0.043773975,-0.036007497,-0.024137756,-0.063064724,0.07737565,0.052161675,-0.029901592,-0.013451317,0.04364016,-0.061561085,-0.010579026,-0.013788953,-0.01526048,0.1024333,-0.02505524,0.0074352734,0.018544527,0.0094043575,-0.017235348,0.030830013,0.11693804,0.055387273,0.1003251,-0.08621262,-0.02099527,-0.008404854,0.002988032,0.01116892,-0.05022111,-0.0049295584,-0.005682016,-0.045901403,0.04539155,-0.04300804,-0.066999055,0.025149565,-0.048022345,0.12319194,-0.102374844,0.026681963,-0.015518788,0.07443982,-0.022985807,-0.0015124457,0.033909913,-0.027384946,0.060225494,-0.016504819,0.0632924,0.00068421743,-0.007947376,0.09766975,-0.00705569,0.06722287,-0.04257089,0.022340838,0.076480225,0.06074905,-0.037375715,-0.042850755,0.025035217,-0.030859504,0.023423357,0.016646069,0.0412284,0.0127935875,0.033110965,-0.07341116,0.039313763,0.0047901766,-0.06393337,-0.13245435,0.011972335,0.008908288,-0.038882576,0.021836437,0.017683277,-0.020459436,-0.019197375,0.011229319,-0.046596497,-0.02131332,-0.018812474,0.039329294,0.005715241,0.055401146,-0.057898484,0.0009065348,0.030947318,0.017676177,-0.0055786823,-0.04231793,-0.0069749807,-0.036640435,0.06836034,0.05699811,0.040758047,-0.027171751,-0.026506066,-0.05767587,1.1530123e-33,0.08933948,0.076078385,0.0053525358,0.0045297784,0.016729021,0.04320257,0.0109007,0.029907364,0.025541868,-0.043018922,-0.017543856,-0.06194299,0.066869415,-0.048274793,0.029675389,-0.031671,0.0108436225,-0.0037638824,0.10328938,-0.06259398,-0.043404747,0.009765019,-0.07627624,0.055567496,-0.028297227,0.025426393,-0.02274206,0.023610849,-0.006689275,0.014159415,0.033970214,-0.036411554,-0.03937679,-0.054759253,0.022463448,-0.04881683,-0.055913325,-0.038419582,-0.14473073,0.008714235,-0.0036985576,0.0111274505,-0.03925437,0.0109083755,-0.012359495,-0.08321099,-0.08293604,0.0811786,-0.044077173,0.07443224,0.011320091,-0.053826034,0.17217405,0.026449254,-0.06909149,0.0017579073,0.0058260188,-0.0028141718,0.040969756,-0.0018315552,0.005177,0.033298533,-0.0769911,0.076279774,-0.106064685,-0.019861985,-0.10644761,-0.06428793,0.025879797,0.057828512,0.10190757,-0.014005969,0.055272546,0.00980504,-0.03814318,-0.036049496,-0.06017741,0.028644253,-0.030584056,0.009303058,0.05947513,-0.035495035,0.039967876,0.017810062,-0.078298055,0.01614571,0.050690793,0.004649228,-0.0070935725,-0.039143298,0.058672495,-0.02299443,-0.03982933,-0.05346488,0.044686925,-1.1477875e-33,0.061980586,-0.10170713,-0.0071833255,0.019927448,0.036923483,-0.053497776,0.058103226,-0.046906717,-0.01811078,-0.07217113,0.05598837,-0.08433778,0.009777703,-0.0014645498,0.011885057,0.09834506,-0.044455614,0.096125476,0.051339082,0.0110426545,-0.08393249,-0.055722944,0.07908198,0.094111644,0.003013602,-0.022668406,0.042093385,-0.077655874,-0.06394063,0.08752049,-0.052736066,0.04339797,-0.08033858,-0.03451661,-0.04171033,-0.006105747,0.007585766,-0.060898192,0.01642436,0.032637954,-0.059476037,0.055868242,0.089064315,0.067959435,0.062199775,0.07600084,0.04548183,0.026125092,-0.005353348,-0.016345967,0.02617903,0.049008355,-0.028277228,0.11716215,0.05228122,0.0027311547,0.03409103,0.04345877,0.029474553,-0.016979977,-0.009885269,-0.10008241,-0.049165864,-0.056043915,0.07268344,0.097497895,0.03519062,0.102781065,0.09628909,-0.03304546,0.055168666,-0.023340844,0.09123134,-0.013408778,-0.011865243,0.035604537,-0.007958778,0.13833752,-0.018774467,0.015832037,0.010292439,-0.046789896,-0.018250616,-0.00019344104,-0.06922207,-0.120097056,0.036704723,0.018553268,-0.034262083,0.058033742,-0.060010888,-0.010092486,-0.05377355,0.02258462,0.06343155,-1.8875381e-08,0.029015224,-0.06363153,-0.04951428,-0.017128553,0.07319475,0.03792455,-0.019959453,-0.0049786754,0.06484924,0.009202263,-0.02535539,0.07657544,-0.007892178,0.06100887,0.06573992,-0.04648404,0.026871309,0.016507192,-0.013512975,0.0013276436,-0.06242673,-0.0045133196,-0.0411914,-0.005651624,-0.030237284,0.015150978,-0.011266211,-0.07227039,0.077648275,-0.06754876,0.01887235,0.026683783,0.013224712,-0.10018296,-0.11779887,0.01730017,0.06207816,-0.036017265,-0.023959516,0.042081017,-0.10255557,-0.0023833518,-0.07205043,-0.004088771,0.019180719,-0.044197347,0.054366738,0.0589435,-0.038279153,-0.09260265,-0.07413941,0.019778527,0.0044452273,-0.012490457,-0.02812746,-0.01566314,-0.006950328,0.010823572,-0.045021247,-0.07028631,0.019342719,0.063436344,0.082315505,-0.014871716 +1.2.2.3,"Yeast cytochrome c, ferricyanide and phenazine methosulfate can act as acceptor.",384,1.0,-0.080341496,-0.048490673,-0.05914119,-0.009155344,0.011148919,0.024292102,-0.0023516878,0.039901786,0.0073600216,0.031117452,-0.009102025,-0.01803855,-0.05723821,0.056351002,-0.063624814,0.014662686,-0.059522495,0.027770206,0.012258301,0.07245231,0.017985338,0.061709456,0.034588344,-0.04657582,-0.046938468,0.009283017,0.009708236,0.047403514,-0.017073367,-0.122771375,-0.025071826,0.06601515,0.050541382,0.018759787,-0.0505552,0.06634082,-0.018763471,-0.0312193,0.0227147,-0.031034071,-0.019260148,0.02059662,-0.017871493,0.02830383,-0.03765218,-0.027263345,-0.0069616954,-0.009651303,0.05132428,-0.076251894,-0.057117388,-0.017966501,-0.020586496,0.069738686,-0.03718184,0.0633812,-0.0914766,-0.035554145,0.023858353,-0.042355686,-0.0941713,-0.035852406,-0.020764852,0.027523573,0.03712464,-0.086396225,0.0104386555,0.0037710837,0.04917971,-0.033380438,-0.021913726,-0.0593806,-0.016562358,-0.037856705,0.009775771,0.1294129,0.055161983,-0.070040315,0.030120883,-0.0023119245,-0.050393622,-0.04560892,0.018654672,0.027529232,0.09963848,-0.05722906,-0.058575872,0.045246523,0.037239477,0.10059322,-0.01358024,0.04791276,0.030547962,0.00033993283,-0.09099162,-0.02853909,0.11831692,0.10784811,0.0062676333,-0.006462138,0.0055373115,0.102372624,-0.01814475,-0.0282983,-0.01510071,-0.04329279,0.07996939,0.03842493,-0.027878422,-0.023380341,-0.039761927,-0.072859205,0.027097888,-0.05603411,-0.01622021,0.04438588,0.0764251,-0.09804992,-0.027099248,-0.09907517,-0.06328926,0.0074714436,-0.002938738,-0.08979593,-0.023826903,0.01072642,-0.034346547,2.8115694e-33,0.0064954376,0.050358884,-0.053566296,0.0064263614,-0.059475586,0.013500885,-0.08982813,0.036091454,-0.0015106677,-0.048764113,-0.06610899,0.02756797,-0.001217156,0.052459706,-0.074225575,0.023042096,0.079103045,-0.009041337,0.06889704,-0.062479105,0.019257754,0.0044336263,-0.052393384,-0.067517996,0.018009406,0.012723622,-0.056575146,0.06483558,-0.019857887,-0.017339172,0.07276517,-0.085866556,-0.034631245,0.04596378,0.05231991,0.06185646,-0.039844777,0.039066494,-0.03994514,-0.02963189,-0.08694529,-0.03294251,-0.039466616,0.01914082,0.054388296,0.019237202,-0.14465989,-0.0033629788,0.015719963,0.09577845,0.013829808,-0.06478952,0.05876891,0.03638052,-0.039979443,0.05095906,-0.006914587,-0.028084736,-0.010379449,0.022611946,-0.013987996,0.13228478,-0.061173853,0.112324715,0.035683934,-0.0102393655,-0.038198613,-0.011745107,-0.019463902,0.09939209,-0.071054205,-0.03166943,0.025929464,0.057259526,0.054532632,-0.0018101168,-0.049030762,-0.056223463,0.025256641,0.037333604,0.038464546,-0.11218844,-0.035776086,0.06176619,-0.075635724,0.02174503,0.023646764,-0.042693984,0.0068270057,0.004699743,0.074580505,-0.12272789,0.008841681,0.011900528,0.04850372,-4.994199e-33,0.13431412,-0.0006210553,0.06273197,-0.05585879,-0.051585335,0.11649809,0.022222662,-0.10919878,-0.023511948,-0.06650732,0.08129364,-0.03978203,0.024403578,-0.025363881,-0.023406364,-0.015197235,-0.0012620667,0.040533308,-0.024158454,0.057891674,-0.05070327,0.085134946,-0.06327617,0.03948225,0.044747774,0.016151486,0.036108844,0.017055605,0.011755047,0.02449178,-0.02024733,0.03866624,0.01851336,-0.099180974,0.05350487,0.0495189,-0.065749,0.0020757774,-0.018128028,0.0056567485,0.035053715,0.047020722,-0.061896827,0.09723333,0.05486226,0.07279057,-0.0103926165,-0.01725033,-0.0044068824,0.006453686,0.008550148,0.04329786,-0.028695622,0.0028137513,0.10233479,0.07511141,0.028555881,-0.09035609,0.024026593,-0.009499492,0.008713932,-0.09695065,0.018636884,-0.058700148,0.015712157,0.018131668,-0.04034177,0.0674032,0.06751649,0.0018813325,0.04871445,0.017934434,0.064143755,0.03282775,-0.023795107,-0.010313652,-0.018695498,-0.039852973,-0.013696219,0.009517947,0.014651754,0.03742706,0.06258659,-0.008332233,0.027493387,-0.082794465,-0.04932761,-0.05206706,-0.049295835,-0.01637067,0.02258814,0.036751665,0.007844617,0.04486095,0.013639511,-2.8088989e-08,0.06541921,-0.009430408,0.055526324,-0.060574554,0.01716412,-0.014012502,0.024362134,-0.06874894,-0.030390996,0.03768332,-0.03993099,0.15127335,0.042266313,0.015235574,0.06407059,0.03462807,-0.07497444,-0.03706818,-0.040832166,0.027542617,-0.10082573,-0.020344427,-0.10815925,0.048081923,0.024673508,-0.067017615,-0.006075896,-0.0065346537,0.037752263,-0.01537458,0.047084354,0.016249213,0.046802834,-0.021550326,-0.0030459303,0.011737225,0.016120166,-0.11889889,-0.07698706,-0.0049414407,0.056145784,-0.012364023,-0.05977086,0.04112608,-0.058975235,-0.022028444,0.03318479,0.0625634,-0.043343823,0.0043610097,0.049502008,0.01966082,0.0386266,-0.035155445,-0.061745554,2.7768228e-06,0.0072244103,-0.0053796316,-0.03557012,-0.071396396,0.038177766,-0.073150575,0.09295733,-0.048871286 +1.2.2.4,"Contains molybdopterin cytosine dinucleotide, FAD and [2Fe-2S]-clusters. Oxygen, methylene blue and iodonitrotetrazolium chloride can act as nonphysiological electron acceptors.",384,1.0,-0.0679626,-0.07052014,-0.07410499,0.012635467,0.14048915,-0.021224076,0.017174013,0.037716813,0.012923549,-0.040560056,0.03094171,-0.016046798,-0.040501367,0.0701778,-0.056495283,0.06539688,-0.014744899,-0.013925648,0.046961952,0.055877164,-0.033315364,0.05453844,0.11324274,-0.08817085,-0.06322054,0.097508,0.024229791,-0.02783457,0.028704725,-0.013938195,0.018549984,0.031528763,0.032767806,-0.026271848,0.05058852,0.06447075,0.025116662,-0.017211767,-0.0053903325,0.013515533,0.024044907,0.03262461,0.020745866,-0.04260211,0.06752783,-0.050667997,-0.004328128,-0.047796663,-0.02294267,0.037041027,0.04936421,-0.01983078,-0.03323833,0.060568597,-0.027727928,0.04176729,-0.058485266,-0.0015157098,0.055989716,0.02560358,0.0039060786,-0.0046219057,0.07700592,0.030113174,0.067315064,-0.011227783,0.035990708,-0.031137832,-0.024097254,-0.08327642,-0.027246542,0.008114888,0.027881728,-0.0014614931,0.016806092,0.06103083,0.046998695,-0.065803625,0.046192992,-0.057404578,-0.037844274,-0.061050784,0.052982513,0.12986019,0.060541656,0.014748597,-0.05713468,0.06982792,-0.11672231,0.017817652,-0.005173743,-0.0019856866,0.016824834,-0.04915833,-0.03309392,0.00029625947,0.074152075,-0.0084434245,-0.034883067,0.001690539,-0.018788505,0.10740671,-0.09802545,-0.07108051,-0.08827008,-0.0003291631,0.02289995,0.019844534,0.03407812,0.0034933435,0.024210986,0.056913603,0.03564718,-0.042163953,-0.014055747,-0.020730814,0.031779017,-0.006620209,0.02599231,-0.03812457,-0.013846294,-0.04967188,-0.0202677,0.038241267,-0.007160324,0.0051995018,-0.07218189,5.934319e-33,0.042307712,-0.005733059,0.02557128,-0.015296571,-0.01340109,0.02202935,-0.02547835,-0.030660855,-0.02689411,-0.079105325,-0.06146533,-0.07333919,0.13069296,-0.006516642,0.013230582,-0.011370298,-0.070732445,-0.058072537,0.102506764,-0.10381478,0.04013157,0.068297304,-0.022330308,0.017598126,0.05163142,-0.008046679,-0.07526288,0.07951551,0.070869446,-0.019329613,0.025473021,-0.027763518,-0.094939075,-0.00236412,0.024691975,0.055393342,-0.040674035,-0.056231692,-0.022770418,-0.016231872,-0.09719184,0.015489536,-0.08060651,-0.038139317,0.064918734,-0.03565497,-0.027576994,-0.0037031034,0.05153539,0.009898255,-0.010300021,-0.09983211,-0.015487096,-0.05815828,-0.07130475,0.03634671,-0.022246461,-0.000749541,-0.012432401,0.08721429,0.02111227,0.00433495,0.008801399,0.06216142,-0.014631164,0.002790487,-0.041476864,-0.053553782,-0.017899273,0.026675781,-0.0032782143,0.03135819,0.058007073,-0.04035574,-0.0032493612,-0.03805619,0.017653124,-0.060075413,0.006341268,0.017407008,0.09364382,-0.12134508,0.037590407,-0.04718814,0.0060367584,0.0035950893,0.003666379,-0.079810545,0.014290321,0.0026635057,0.067650944,-0.09864766,-0.07989926,-0.08340674,-0.039573647,-6.374524e-33,0.093278795,-0.0133369,0.0742402,-0.072849944,-0.050325472,0.05695242,0.01663808,-0.040019773,0.08978186,-0.046374723,0.084021546,0.065551385,0.019406822,-0.12693536,-0.0099269645,0.023229795,-0.06462951,0.09811735,0.10915966,0.050982893,0.0035998225,-0.006310632,0.023060884,0.082842834,0.08875124,0.05068887,-0.08000593,-0.024701878,0.063073955,-0.0067548286,-0.020234512,0.02230998,-0.09530823,-0.030330524,0.055974018,-0.016022785,-0.048606697,-0.021488907,-0.04631641,-0.025986783,-0.09026373,0.0035690803,0.0057073613,0.12380562,0.018100956,0.055249445,-0.073445715,0.01746121,-0.029122263,-0.025281718,-0.029260097,-0.01120424,-0.044565003,0.039300237,0.111869365,0.07725122,0.025267439,0.01120051,0.047541805,-0.012962491,0.0037955288,-0.068357155,-0.0065696947,-0.005311964,0.08022118,0.0073916065,-0.017796416,0.12385997,0.041876823,-0.023780763,0.047577802,0.017742133,0.007298475,0.017186861,-0.032070998,-0.01604601,-0.026822204,-0.018407851,-0.0020841975,-0.0032155972,0.049773768,0.07737437,-0.036664408,-0.028351957,0.02531695,0.0028672118,0.020176632,0.08742763,-0.020797694,-0.056313816,-0.05323337,0.0356624,0.071321554,-0.030979004,0.0138754705,-4.0516234e-08,0.03456948,-0.10786524,0.00572384,-0.11448269,-0.009123953,0.024185084,0.015578791,0.020299021,-0.06551967,0.017169228,0.03665425,0.044711046,0.021506144,-0.096609905,0.05299072,0.032867547,-0.06360064,-0.012633015,-0.03476864,0.031854868,-0.06852143,0.009939061,-0.13442114,0.06880492,-0.02284617,-0.021543339,0.055187095,-0.013180047,0.03275488,0.0005579105,-0.023135772,-0.0708024,0.065369725,-0.03155178,-0.055705845,-0.014417946,0.010843512,-0.0500476,-0.07967508,-0.010544028,-0.007105127,-0.038863312,-0.008313519,0.008322589,-0.007053206,-0.0064409077,-0.0034376935,0.071555644,-0.022357767,-0.0039451984,0.009519689,-0.09413411,-0.010108424,-0.03158079,-0.12803452,0.02136751,-0.0589268,-0.026165307,0.076477274,-0.03739227,-4.7936323e-05,-0.00037616544,0.12197603,0.01918203 +1.2.3.1,"Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme, retinal oxidase (formerly EC 1.2.3.11) [5,7].",384,1.0,0.0036998398,-0.101345874,-0.033045713,0.056692667,0.12642862,-0.04281198,-0.0037434355,0.021825014,0.028083593,-0.005278675,0.017208522,-0.015802741,-0.05950624,0.060725983,-0.08242172,0.02558288,-0.07196851,-0.034922756,-0.002544743,-0.02336703,0.07924922,-0.03785169,0.03137296,-0.06608398,-0.012773071,0.033655718,0.05868766,-0.040307306,-0.027742952,-0.097555205,0.025315553,-0.0053940224,-0.020378897,-0.061418887,-0.016823668,0.04183411,0.034536548,-0.06950166,-0.046079613,0.021201573,-0.03172615,-0.0010953535,-0.06719224,0.010644926,0.06374791,-0.06520971,0.057809122,0.035692967,0.01889692,0.020020045,-0.072986536,-0.07112232,-0.06543086,0.014898259,0.072007515,0.09252979,-0.068788506,0.029683748,0.04608319,0.035741426,0.03838739,-0.02814693,0.08935874,0.015428922,-0.026392365,-0.01565385,-0.007088502,-0.10404811,0.019282065,-0.08862898,-0.061142683,-0.060323466,0.07585578,-0.049804974,-0.07456971,0.015840132,0.016575092,-0.032026425,0.06583917,-0.056807842,0.02737171,0.01554206,0.055461384,0.08491709,0.12790512,-0.034015253,-0.023202205,-0.034155667,-0.021442035,0.04567156,0.024003234,0.005686267,-0.004558414,-0.009101577,-0.058480024,0.02016083,0.04867971,0.050459657,-0.07345122,-0.040558875,-0.02985613,0.036252484,-0.01104995,-0.06188302,-0.07000065,0.0040544956,0.035147175,0.14261997,-0.0019397646,-0.030640364,0.028579855,0.100146145,-0.010834914,-0.0038822305,0.01035089,0.057921376,0.04270999,-0.04277342,0.00069888163,0.0029578807,-0.03853585,0.015727513,0.04874971,-0.0126242945,-0.0016624866,0.025876626,-0.0040988214,1.1091764e-33,0.060946766,0.06698274,-0.037251,-0.012251875,0.06354642,-0.035535667,-0.046997827,0.066590704,-0.020912228,-0.03532889,-0.011498455,-0.0665433,-0.003256521,0.026403127,0.04138039,-0.033160515,-0.020015568,-0.024741387,0.07527776,-0.030079415,-0.03845125,0.01869694,-0.034350645,-0.008361924,-0.011688287,0.049495257,-0.016463164,-0.010389781,0.03578514,0.029978126,0.042691115,-0.05405801,-0.055685744,0.00023446679,-0.021329712,0.032844074,0.008133665,-0.01051146,-0.021331176,0.019508377,-0.019866401,0.043705605,0.00928276,-0.06424721,0.04852416,-0.05355665,-0.07561801,0.1467841,0.05981922,0.031488795,0.0046438477,-0.06370963,0.06058966,-0.028203981,-0.054398756,0.031765163,-0.06849138,0.059480563,0.050352357,0.04292277,0.014428559,0.045102376,-0.0030210637,0.11419997,-0.0008676222,0.01175194,-0.05245242,-0.05947503,-0.08985152,0.040109616,-0.028979694,0.075772345,0.079855904,-0.044903744,0.015778923,-0.021643078,0.009850781,0.0029034675,0.0447369,0.032371685,0.0049743806,-0.010079241,0.09395333,-0.06964921,-0.008357636,0.0069144317,-0.029545765,-0.005269879,-0.03048281,0.05786163,0.07492522,-0.056614928,-0.07158992,-0.062677585,0.006186958,-1.5812647e-33,0.040699095,-0.06852026,0.09315904,-0.10172047,-0.09347359,0.03034902,-0.033083253,0.009777237,0.044643182,-0.089918666,0.0317528,0.016261863,-0.00075014296,-0.042036057,-0.01666371,-0.050206427,-0.026726253,0.053153776,0.032557033,-0.066709734,-0.042424724,0.06472405,0.055870038,-0.03590039,0.06485982,0.082055725,-0.018204669,0.009785817,-0.0063346997,0.046575565,0.0044958773,0.015253052,-0.053468984,-0.020448675,0.024282774,0.008598018,-0.12276782,-0.013603883,0.0012733754,0.08616019,0.013990935,-0.0010550676,0.017453639,0.047718436,0.041778054,0.03428829,-0.12652104,0.024786659,0.05867172,-0.08577856,-0.024064891,-0.0028003869,-0.07988231,0.01312878,-0.020091826,0.06494385,-0.023474542,0.03378517,0.03909478,-0.024044856,-0.0037178232,-0.06926074,0.032344155,-0.019201862,0.07483972,0.04423842,0.014874326,0.08300508,0.07558025,-0.044275057,0.12419551,-0.050412275,-0.06572443,0.08147734,-0.047932237,-0.030238725,-0.017175894,0.059887264,-0.036445424,0.0042683985,0.058953945,0.013726124,-0.050284553,-0.02943231,-0.008326183,-0.0341755,0.02830393,0.1492239,0.044220787,-0.06957732,-0.047512893,-0.021023756,-0.1208793,-0.000726437,0.05588517,-4.1354063e-08,0.0070107533,-0.06850535,0.07715982,-0.013422525,0.051332768,0.06545682,0.0005999448,0.034936856,0.025936363,-0.039155137,-0.0124538895,0.116902076,-0.002343739,-0.0015420583,0.01034899,0.060056265,-0.03482102,-0.012805238,0.0027200459,0.010337905,-0.058028072,-0.042415828,-0.05413064,0.0740409,-0.042222477,-0.08099337,0.031930283,0.01516378,-0.02221761,-0.026496993,0.017328797,0.027793841,0.07937896,0.039950814,-0.10899275,-0.027750457,-0.027665766,0.016510304,-0.0708149,0.00089942425,-0.0962903,-0.061265983,0.03672222,0.009544236,-0.00978324,-0.041032493,0.01642074,0.040956426,0.01396648,-0.01057798,-0.051682994,-0.044799004,-0.02391697,-0.057590872,-0.16872628,-0.023620684,0.030457329,-0.020693269,-0.0028477747,-0.106096484,0.0467712,0.03488935,0.107933685,-0.0001358556 +1.2.3.3,"A flavoprotein (FAD) requiring thiamine diphosphate. Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin. FADH2 is reoxidized by O2 to yield H2O2 and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate [2].",384,1.0,-0.05970859,-0.04400535,-0.069119275,-0.007435296,0.09155272,0.027149543,0.018732373,0.04382194,-0.009202451,-0.032241993,0.026031278,0.033415377,-0.047722988,-0.010334222,-0.067014925,0.058510195,0.018865215,0.012239082,-0.023618538,0.0099992985,0.032479852,0.021109061,-0.00537995,0.0027403815,-0.014368813,0.015995806,0.022067236,-0.033607766,-0.002243806,-0.04683955,0.010417899,0.07989898,0.033501107,-0.072463565,-0.06598838,0.08067899,0.009978656,-0.014198063,-0.025516763,-0.043237433,0.05881448,-0.004290537,0.03829742,-0.014105662,0.037630092,-0.00853343,0.017804759,0.10178708,-0.023410264,0.07260693,-0.054882232,0.008655182,-0.09348438,0.024910111,0.036122516,0.027454011,-0.028989762,0.0023277663,-0.04087795,0.05877643,0.018945001,-0.042194262,0.008663165,-0.011713281,0.08661995,-0.07788719,0.006686862,-0.02450124,0.034107123,-0.01642376,-0.0031482107,0.03476379,-0.01017792,0.0028394798,0.021509819,0.0787577,-0.06735169,0.0049214326,0.09230521,-0.0038899116,0.07489781,-0.058367588,0.043813396,0.07679282,0.05068883,-0.05981645,-0.091261044,-0.0036325522,-0.030893782,0.02553183,0.025016204,0.049336236,0.040671322,-0.010883332,-0.09079816,0.06745331,0.021631425,-0.02890632,-0.084138274,0.009958071,-0.046963125,0.008285148,-0.007569771,-0.055912834,-0.040682796,-0.056253485,-0.025722958,0.030267287,-0.02083433,-0.010581873,0.018687438,-0.015633982,0.057368934,-0.069219254,-0.019907422,0.08156376,-0.040585034,-0.048482273,-0.05239217,-0.028953582,-0.040014286,0.06607184,0.073373295,0.041830234,-0.002265703,-0.032796044,-0.09213156,1.0607172e-32,0.06719679,0.054220013,0.0076761367,-0.030635806,0.0103583615,-0.03353927,-0.0628284,0.011574117,0.056890123,-0.050484687,-0.028795887,-0.04002,0.08301819,-0.042930633,0.015016638,-0.09223673,-0.04196244,0.0053048898,0.12764186,-0.08606549,-0.006918543,0.09417529,-0.045281213,0.07615464,-0.0010535716,-0.03046425,-0.034984663,0.027563568,-0.014044598,0.03281812,0.07382988,-0.04594345,-0.091592714,-0.040561736,-0.0066917646,-0.036990665,-0.10212288,-0.07920972,-0.11717728,-0.002051629,0.014340444,0.018648792,-0.060595337,0.020038996,0.018609075,-0.105580114,-0.07739256,0.075800136,0.0150753595,0.09421243,0.031666003,-0.053387765,0.1044617,0.040908262,-0.11006911,-0.008146357,-0.007744634,-0.027501998,0.03489088,0.022741875,-0.0039013796,0.0017683211,-0.027123008,0.063824594,-0.06941741,-0.01841441,-0.060091037,-0.08684806,0.030989554,0.083078295,0.10218499,-0.013706019,0.05360033,0.04404157,0.018603763,-0.07801804,0.008266244,0.0015369093,-0.008474343,0.025900194,0.028021593,0.01891556,-0.019453662,-0.008318969,-0.016483271,-0.0048513664,0.023521688,-0.046108108,0.041852802,-0.0002092327,0.018056812,-0.07900828,0.005139403,-0.040091895,0.07236662,-8.816273e-33,0.056537133,-0.08198404,0.0154147325,-0.007442319,0.010434269,0.012137077,0.07206006,-0.04641175,0.022648666,-0.06387187,0.02935865,-0.059053086,0.025987186,-0.005265469,0.049224667,0.03662874,-0.040863797,0.042976644,0.0536291,0.010835171,-0.018050727,0.0021564788,0.08403443,0.08604464,0.024579002,-0.00055119,0.0024297917,-0.040424526,0.038360417,0.09414146,-0.057510603,-0.0028004143,-0.10523734,0.006378088,-0.06756497,0.01114892,0.0106155295,0.025898503,-0.051934592,0.03862137,-0.008588361,0.04208712,0.031143416,0.044733245,0.0436962,0.08090811,-0.038109288,-0.011034715,-0.027700445,-0.07401031,0.040961016,0.041381367,-0.06554352,0.06597008,0.06374757,0.04120095,0.05652733,0.051858757,-0.012236247,-0.018902756,-0.021778831,-0.11415166,-0.04089903,-0.053142928,0.08332626,0.06203604,0.07224506,0.121573895,0.0012812805,-0.035564195,0.04040515,-0.019124772,0.080638774,0.034335013,0.039768737,-0.013983569,-0.014935717,0.06852969,-0.033340566,-0.009685047,0.064103335,-0.024519464,0.004424362,0.015195467,-0.08902025,-0.10613989,0.00820759,0.03165473,0.0021549226,0.081588775,-0.065263726,0.05616065,0.0049289493,-0.016134363,0.103154145,-5.073048e-08,0.021584198,-0.08147769,0.0490776,0.00626649,0.05505071,0.05897752,-0.053944357,0.016326316,0.019357929,-0.059031595,-0.026978076,0.1055598,0.016735537,-0.013370975,0.037936553,-0.051503897,-0.006363683,0.03595182,-0.05528087,-0.03166202,-0.07834629,0.0346273,-0.061695118,0.0028932376,-0.04261065,0.0114247305,-0.018406127,-0.10118085,0.05460741,-0.04174282,0.053477798,0.012463594,0.033129435,-0.102491565,-0.14554642,-0.005778465,0.069160715,-0.043446537,-0.06694072,0.054274615,-0.11996408,-0.005687057,-0.053770818,0.022155808,0.051891215,-0.032514848,0.059200987,0.04316725,-0.071860254,-0.046376415,-0.029813813,-0.013334203,0.0028345876,-0.07709083,-0.07592645,-0.0433049,-0.008526323,-0.020286474,-0.005251231,-0.07270373,0.02682652,0.09865259,0.12516664,0.010236006 +1.2.3.4,Contains Mn2+ as a cofactor. The enzyme is not a flavoprotein as had been thought [3].,384,1.0,-0.016232053,-0.08586791,-0.09496787,0.062568955,0.13049379,0.012876562,-0.014916802,0.03440244,-0.047865354,-0.035894074,0.041222885,-0.004572418,-0.009153687,-0.011743646,-0.039168194,0.053483795,-0.034955632,-0.05496891,-0.012640586,-0.0021353895,0.053059433,0.0024274236,0.03412536,-0.06440692,0.07178633,0.0838696,0.02641323,-0.08300268,-0.021898832,-0.016319552,0.017543823,0.07324722,0.08139841,-0.061348554,0.022221748,0.055072114,-0.018931951,-0.05284305,-0.005425654,-0.00433193,0.047892626,0.03147537,0.121787734,-0.03405661,0.057301067,-0.0001846569,0.01287801,-0.03839271,-0.0033570095,0.1299947,-0.07661871,-0.043843992,-0.083434224,0.0344312,0.014119016,0.007185305,-0.08922238,-0.018110674,-0.0651956,0.042291436,-0.004856836,-0.031910777,0.029095745,0.003650915,0.07015565,-0.031696066,-0.044290077,-0.03688483,0.06350029,-0.05753573,0.05001907,-0.004913736,-0.036106434,0.055982813,0.01032686,0.06442023,0.04564738,0.015694201,0.09607908,0.004870678,0.0071842526,-0.0051486036,0.1211099,0.073725946,0.04498982,0.05961146,-0.037042085,0.021454796,-0.040860265,0.025232436,0.019171637,0.048347108,-0.009704524,0.06283033,-0.031962097,0.044303905,-0.00818381,0.054871693,-0.07049148,-0.018039338,-0.02849116,-0.043543566,-0.02535133,-0.06089727,-0.028637161,-0.027329318,0.050272662,0.058347665,-0.0050006732,0.007827485,0.044551514,0.04710617,0.07036977,-0.031243525,0.036460396,0.059033312,0.048375696,-0.047382034,-0.027712185,0.020329246,0.025150778,0.06512423,0.039771408,0.057627376,-0.04495051,0.011601067,-0.08182201,3.791022e-34,0.045355868,0.036013555,0.01169367,-0.04436965,-0.0037167505,0.02306936,0.007144875,-0.015435129,0.027871793,-0.060801294,-0.102154985,-0.033694673,0.052138675,-0.00091933174,-0.002726297,-0.055215277,-0.0013043387,-0.06718514,0.11295306,-0.032307122,0.02730577,0.04430596,-0.0676573,0.0238924,-0.034067515,-0.019684754,0.031534426,-0.032056417,0.038493022,0.020945666,-0.056128755,-0.11053615,-0.07605579,-0.0041204197,0.023059152,0.03072217,-0.08126658,-0.07446253,-0.13708377,0.0260408,-0.030832443,-0.013844936,-0.10208094,0.025043335,0.00022327919,-0.08844801,-0.1051114,0.04201366,-0.010298405,0.02840674,-0.000702595,0.023223514,0.091468416,0.06944525,-0.09494624,0.044562127,0.026104182,0.061606478,0.03900909,0.041789267,-0.061504856,0.04770857,0.030550376,0.05956348,-0.0461206,0.0028052342,-0.038206175,-0.070264384,0.014565948,0.07544109,0.06910831,-0.05088614,0.07236919,0.010045267,0.026530748,-0.06804214,-0.06471033,-0.006293006,0.026614824,0.054266304,-0.010494949,-0.049587242,0.022284925,0.009153641,-0.10892354,0.03672206,-0.0130303865,-0.07319522,0.006104793,-0.002735806,0.07361198,-0.03260888,-0.0377854,-0.0055803,-0.026338339,-7.2967875e-34,-0.007063297,-0.07267832,0.019259589,-0.015747577,-0.07857396,-0.00041624848,0.04387607,-0.10619625,0.049753647,-0.0453232,0.09090281,-0.07728761,-0.07141431,-0.013478617,0.014557198,0.048357017,-0.011727542,0.09203621,0.09895933,0.026972197,-0.035347052,0.01646886,0.024173565,0.0649855,0.016733622,0.016452782,0.018293437,-0.0487028,0.043282732,0.03615999,-0.04510641,-0.014520887,-0.05624617,-0.06492763,-0.047301736,0.0047687506,-0.046464875,-0.083343215,0.016596075,-0.003095809,0.010241434,-0.0011831534,0.00636239,0.077252276,0.03308931,0.006428244,-0.037169922,0.06772925,0.03328943,-0.009679681,-0.018033871,0.008591948,-0.06141441,0.032416485,0.016465323,0.027009632,0.06625691,0.034297463,-0.006005947,-0.00879715,-0.03058551,-0.08010615,-0.01963604,-0.018213958,0.115255,0.11895718,0.042534325,0.069782495,0.0013912403,-0.017460555,0.071812905,0.011915369,0.058704846,0.08350588,0.017152747,-0.05704393,-0.026484458,0.084921084,-0.005407217,-0.06033088,0.044401404,-0.021676779,0.019614533,-0.029409124,-0.026956398,-0.0951538,0.015818033,0.07010102,-0.0016673701,0.0534813,-0.011188145,-0.06344347,-0.058700264,-0.007798654,0.05319498,-2.54689e-08,-0.002914308,-0.073195726,-0.009942556,-0.04989327,0.017476793,0.05628387,0.020291803,-0.077398896,-3.7375496e-05,0.018608337,-0.006362927,0.07290239,-0.072624676,-0.0097258575,0.0070221117,-0.043228514,0.0222771,0.054876935,-0.027430413,-0.0075858175,-0.033809893,0.022393104,-0.105767265,0.044680938,-0.044965748,0.029354759,-0.036584698,0.020109149,0.09996184,-0.04465734,-0.019623693,0.019314615,0.03412446,-0.08716896,-0.14483358,0.04298594,0.07214422,-0.055481754,-0.05825525,0.06388919,-0.13191397,-0.0010308314,0.013377442,-0.018162856,-0.0007484372,-0.053060893,0.027735053,0.016228518,-0.007637619,-0.050312273,-0.00013358372,-0.048166677,-0.040680293,-0.054048706,-0.059138793,0.0005845902,-0.0050648563,-0.04673229,0.0021428168,-0.07996802,-0.004310157,-0.00032710243,0.15373747,0.00048819353 +1.2.3.6,A flavoprotein (FAD). May be identical with EC 1.2.7.1 pyruvate synthase.,384,1.0,-0.08005361,-0.068288885,-0.08712,0.02549897,0.106619224,0.027570033,-0.036906328,0.072488815,0.04933418,-0.051032834,0.006126508,-0.010800506,-0.09752753,-0.038819697,-0.06452894,-0.016467948,-0.04833137,-0.08563129,0.0004790357,-0.024763593,-0.014762392,0.0194031,0.07601437,-0.002001094,0.04644608,-0.020647153,0.043350466,-0.01034853,-0.011265011,-0.021037674,0.07422315,0.032685794,0.043771915,-0.014727091,-0.00462434,0.059745494,0.024060966,-0.04122502,-0.038172048,0.019471208,0.10560002,0.014104058,0.044545583,-0.009524572,0.030876111,0.032091543,-0.025255771,0.060026143,-0.046707533,0.0409503,-0.0021708785,-0.054521427,-0.13672437,-0.0004786168,0.03461284,0.054709915,-0.046608645,-0.044544507,-0.042958595,0.012128249,-0.02643306,-0.0069054277,0.070216745,-0.038847774,0.020069946,-0.0656962,0.027000863,-0.070708625,0.043166887,-0.051533364,-0.058504563,-0.039387267,-0.0038475164,0.06601124,0.0322085,0.09027754,-0.07918187,-0.027540548,0.039758425,-0.021366669,0.051531997,-0.038426228,-0.0011444585,0.011443811,0.014095874,-0.053848326,0.038446624,-0.030882945,-0.032309085,0.052196603,0.0042410484,-0.007484859,0.03458626,0.046423282,-0.057853237,0.0686928,0.07226277,0.012919321,-0.035623383,-0.048745304,-0.056607004,0.05695674,0.017032335,0.026246248,-0.051580545,-0.075668134,-0.016442303,0.063871376,-0.018414022,-0.07193533,0.04086863,-0.024204187,0.06760864,-0.053931013,0.03349583,0.0048153694,-0.04076122,-0.049198914,0.006189463,0.053321417,0.00625891,0.07293322,0.07675853,0.10171045,-0.018088644,-0.010125827,-0.12778373,8.1554595e-34,0.053964753,0.008010811,0.015343703,0.009449977,-0.009605246,0.013521143,-0.11197071,0.033315953,0.03805457,-0.032155972,-0.069372,-0.03062922,0.058191594,-0.033269,-0.020446504,-0.027765421,-0.043930408,-0.011760336,0.0433631,-0.13306056,0.048954714,0.032580215,0.015664648,0.050316755,0.034228038,0.0033723393,-0.0619995,0.04356865,0.0426635,0.010914969,-0.025511254,-0.07506479,-0.04749133,-0.0079371855,-0.065789014,0.018403713,-0.031771332,-0.108167626,-0.06991226,0.06633087,-0.021258857,-0.0034954161,0.009178529,-0.03595936,0.018040368,-0.030513547,-0.066940725,0.10273504,0.03236247,0.059536368,0.0034969389,-0.05437047,0.13846138,0.04840787,-0.04043576,-0.003647125,-0.020355988,0.010818075,0.031067679,-0.00042363702,0.06313922,0.13450648,-0.022115555,0.044500764,-0.11130064,0.006011628,-0.022915162,-0.06833366,-0.02659647,0.11469023,0.03592516,-0.031885616,0.1152186,-0.020129915,0.09313908,-0.06151345,-0.109871104,-0.008932161,-0.069093846,0.02631117,-0.061580144,1.9130835e-05,-0.0202926,0.015170695,-0.06633545,0.017055359,-0.022213005,0.013985473,0.044720057,0.07011071,0.024600832,-0.015222099,0.026329266,0.031965286,0.019126803,2.7390855e-34,-0.00020859798,-0.09188553,0.0005361308,0.03166013,0.030479867,0.012503773,0.040828142,-0.026979666,0.021790506,-0.082617246,0.08792861,-0.08245744,-0.03222345,-0.021508403,0.06974923,0.03762663,-0.05457788,0.036042884,0.05937975,0.07600545,-0.048853442,-0.039939776,-0.009577051,0.071136914,0.060998086,0.014543863,0.057994504,-0.010791214,0.016656388,0.010478907,-0.054347727,0.027578497,-0.091122426,0.0006448697,-0.08591618,0.0051660086,-0.031378783,-0.032649923,-0.031559993,0.0065739877,0.0077000773,0.06925852,-0.0020194259,0.05398894,0.08548575,0.05855511,0.03148188,0.022422496,0.08019473,-0.00741925,-0.0027670113,0.030396994,-0.028201766,0.028681248,0.035315838,0.056988943,0.053021703,0.07715942,0.0068916674,-0.020776186,-0.0055155414,-0.13892217,0.028540013,-0.009769569,0.08621378,0.068294816,0.040190406,0.12137998,0.034716677,0.045159735,0.13321611,-0.024157882,-0.009045407,0.03259162,0.04251822,-0.040391985,0.00056876364,0.08629523,0.016584247,-0.03425684,0.019503875,-0.01606504,0.009850714,-0.0057165255,-0.06929337,-0.07874941,0.01862507,0.060889274,0.013359088,0.04880149,-0.044727437,0.0077974536,-0.05319203,-0.04765772,0.07037476,-2.4184267e-08,0.036216915,-0.05550411,0.000752174,0.02472748,0.116843514,-0.009235461,-0.029380785,-0.000765133,-0.0033787512,-0.0046732253,-0.04733774,0.08517246,0.04545592,-0.017205134,0.045791037,-0.024627082,-0.039766166,0.072021194,-0.007442774,0.0049214996,-0.09384953,0.040757623,-0.10130621,-0.019558722,-0.060361948,-0.045194063,0.003449703,0.01879584,0.037437327,-0.06998374,0.038651098,0.03001006,0.056577146,-0.05412441,-0.10134429,-0.0007516487,0.029977428,-0.018606253,-0.034718804,0.08939566,-0.083134055,-0.056983713,-0.014275768,-0.031384513,0.0074407533,-0.000882676,0.06733817,-0.048564218,-0.028568704,-0.039476935,0.029019048,-0.006679463,0.01779194,-0.030862104,-0.033329446,-0.019335294,-0.03463912,-0.0653501,-0.020213569,-0.069432415,0.020766398,0.03215721,0.11729718,0.004639902 +1.2.3.7,"A hemoprotein. This enzyme is an isoform of aldehyde oxidase (EC 1.2.3.1). It has a preference for aldehydes having an indole-ring structure as substrate [6,7]. It may play a role in plant hormone biosynthesis as its activity is higher in the auxin-overproducing mutant, super-root1, than in wild-type Arabidopsis thaliana [7]. While (indol-3-yl)acetaldehyde is the preferred substrate, it also oxidizes indole-3-carbaldehyde and acetaldehyde, but more slowly. The enzyme from maize contains FAD, iron and molybdenum [4].",384,0.99999994,-0.044856615,-0.06788132,-0.10981782,0.016289085,0.11511187,0.025846131,-0.09776926,-0.014863367,0.056817897,-0.02371224,0.0780943,0.014132065,-0.12800255,-0.05359103,-0.008865158,0.07303001,-0.039742317,0.024896596,-0.021364339,-0.07405607,0.019390956,0.044928774,0.0015498907,-0.026626285,0.07929249,-0.09620619,-0.01739305,-0.008300591,-0.061221372,-0.06986512,-0.00066443894,0.029755343,0.07035393,-0.019714657,-0.018593704,0.025007078,0.03397599,-0.11116969,0.03054301,-0.05560299,0.003721363,-0.02805093,-0.059601735,-0.048302077,-0.064535655,0.0043445784,0.043586,0.025156697,-0.027237523,0.0189487,0.019271579,-0.061833628,-0.075449094,0.013300332,-0.0024619598,-0.03794797,0.053589225,0.06365517,-0.021127338,0.059770238,-0.018588422,0.0069250115,-0.05082216,-0.0009887209,-0.0060717235,-0.053688496,-0.0093275765,-0.074566506,0.014066165,-0.073611386,-0.046033375,-0.08293201,-0.0534852,0.04353875,-0.032025333,0.08463921,-0.05627471,-0.021919886,0.09580463,-0.031194633,0.019330867,0.061606593,0.080579,0.094341196,0.013057375,-0.01834485,-0.049565725,0.05994313,-0.039010532,0.02218954,0.03192285,0.018892014,-0.035989013,0.015869869,-0.0067465235,0.109174326,0.08060253,-0.017452756,-0.03099289,-0.036874592,0.020426473,0.044832267,-0.038995717,-0.03624926,-0.045934703,0.028185824,-0.035774227,0.02722104,0.004523116,-0.010707003,-0.035030533,0.017224852,-0.01377649,-0.02158225,-0.049582146,-0.02034311,0.0028705394,-0.029685933,-0.03941559,0.023872312,0.0038263923,0.08845778,0.05395334,0.08609726,0.01198896,0.03601751,-0.10157409,1.6358776e-33,0.05978072,0.059979994,-0.05739884,-0.03504039,0.015856244,-0.016825028,-0.05826022,0.04458668,0.02950997,-0.03233996,-0.04076391,-0.09169762,0.04953794,-0.05659027,0.04015194,0.016853357,-0.12127492,-0.042135265,0.06822778,0.052934114,-0.010565327,0.00059264037,-0.08324267,0.036105704,0.016561378,-0.012796049,-0.026731486,0.008430873,-0.018306099,0.014597513,0.037468027,-0.07269256,-0.04890222,-0.049265053,0.02005561,0.0087309275,-0.045450196,-0.036271974,-0.09700811,0.04527344,0.00992974,0.051275395,0.042827744,-0.033872515,0.06186057,-0.030773988,-0.04906813,0.13289753,0.035674855,0.10820381,0.025814353,-0.016899336,0.14088063,-0.012472166,-0.047968984,0.06021131,-0.0048107225,-0.013688815,6.8193556e-05,0.05772783,-0.037326247,0.039934386,0.01818916,0.029389346,-0.054121982,0.013688493,-0.075337775,-0.030144516,-0.020380853,0.13885136,0.0064705443,-0.025677297,0.04875232,0.0056280475,-0.03070132,-0.018374179,0.003168613,0.010781958,0.025162768,-0.04201276,0.0064718914,0.014234119,0.03387238,-0.08814202,-0.028552858,-0.020440241,-0.09612473,0.024837473,0.025445433,0.031962544,0.09503179,-0.03848515,-0.041817736,0.0023345011,0.011452751,-2.017249e-33,0.10542231,-0.07978862,0.028810035,-0.08650275,-0.015613325,0.008156972,0.0189876,-0.020561298,0.022747256,-0.0012377779,0.04923995,0.009497584,0.023527043,-0.03084026,0.07092597,-0.014216168,-0.059867717,0.064555645,0.06583244,0.035199553,-0.0439872,0.076155044,0.036746252,0.0074513215,0.10980118,-0.039898746,-0.07720787,0.028263485,0.0619203,-0.0051775,0.014944704,-0.019292602,-0.02117039,-0.0512915,0.040042777,0.012812524,-0.08973888,0.039406687,0.024433363,0.05818765,-0.07041356,0.067791305,0.019076135,0.061408058,0.056356907,0.053042676,-0.10045261,0.031445514,0.009357562,-0.009080471,-0.0019883749,-0.018710287,-0.033905245,0.061363984,0.038543373,0.032356463,0.05176124,0.042628236,-0.044206437,-0.0014558116,-0.029078439,-0.019119084,0.03346381,0.019895881,0.014904531,0.0595916,-0.0094909035,0.092966385,-0.0025266558,0.073379666,0.08787506,0.004637215,0.0017072243,0.047888335,-0.012449116,-0.06456398,0.038060434,0.060601927,-0.0796479,0.027470239,0.001376734,0.05618642,-0.018450009,-0.00734195,-0.026487907,-0.040601723,-0.022746768,0.17450245,0.024501624,0.029371897,-0.04224643,-0.021263987,-0.026328092,0.012150586,0.0653131,-4.682673e-08,-0.07314591,-0.064222686,0.050183345,-0.059056077,0.0053566685,-0.0069880895,0.027424479,0.0030949977,0.02246152,-0.024168817,-0.0059613823,0.120999835,-0.022935325,-0.011618541,0.030928444,-0.05098003,0.00434041,0.06967403,-0.013820558,0.02798888,-0.03401994,0.0373204,-0.11484573,0.05509727,-0.0016626801,-0.05418897,-0.013515492,-0.034123514,0.08208214,0.0251189,0.019179089,0.080167525,0.0036887003,-0.08333637,-0.1414133,0.02574095,0.00842037,-0.034363557,-0.06037182,0.014750982,0.0056816544,-0.09473034,-0.019379202,-0.036636315,0.055184685,-0.071322046,0.059447974,0.0054787453,-0.0015030307,0.008630212,0.009755711,-0.045869708,-0.008740846,-0.052006993,-0.034413487,-0.0047116545,0.0051383157,-0.0893629,0.003292605,-0.05590514,0.026683081,0.025268203,0.17659418,0.0009787949 +1.2.3.8,A molybdenum protein.,384,1.0,-0.057789776,-0.10159288,-0.07879037,0.012779828,0.006347619,-0.06955515,0.023978738,-0.0068427785,0.040866874,-0.09939824,0.03475878,0.030188493,0.01990616,0.013718661,-0.09729213,0.01204493,0.025402045,0.00934008,-0.01678378,0.029906865,0.03711482,0.07406415,0.041264046,-0.036125533,-0.008970744,0.01138494,-0.014261996,0.007741523,0.03623872,-0.10017346,0.032965545,0.04694001,0.009078177,-0.043097213,0.0701626,0.026245879,0.026683442,-0.021071693,0.054482363,0.011442532,0.03792833,0.032129683,0.08208513,-0.048428632,-0.013835766,-0.020187149,0.018378973,-0.008601038,0.041396942,0.047653478,0.014534657,-0.11617038,-0.062801324,0.06139532,0.02442678,0.029707754,-0.1158972,0.06274343,0.02370558,0.017830763,-0.029074134,0.085555576,0.11365185,0.061690524,0.0439581,-0.07428597,-0.044322893,-0.05384549,0.014065692,-0.029594472,0.01195975,-0.007493401,0.069520324,0.07666583,-0.043927442,0.06500095,0.0023920818,-0.0021027979,0.12053721,0.013302012,-0.029030649,0.03677869,-0.0011988991,0.08715254,0.013957637,-0.025836578,-0.002883252,-0.00011584376,-0.04899801,-0.047918163,0.04206389,-0.014882275,-0.028001346,0.017632756,-0.06989596,-0.03651803,0.06927305,-0.06934922,-0.10705554,0.03259745,-0.02773402,0.009830128,0.05775041,-0.07823074,-0.06532504,-0.053603657,-0.027231773,0.050267395,0.021666592,0.020625299,-0.0073557976,0.057960767,0.044584274,-0.052531276,0.02756874,-0.05530506,0.03020484,0.029949635,-0.03134892,-0.06324667,-0.044924404,0.013519145,-0.029168895,-0.017852565,-0.079401165,0.051460076,-0.014660385,-2.0155366e-33,0.11114452,-0.059556518,0.06683709,0.045136124,0.019336672,-0.029378664,-0.027470093,-0.042833664,-0.0040305154,-0.0850701,-0.03140898,-0.080381416,0.016789954,0.034804452,0.020593569,0.0023599232,-0.07491163,-0.07925843,0.07540444,-0.0010620154,-0.040429004,0.11101767,0.019960627,0.034402397,0.060136747,0.0030234074,-0.002454,-0.060672116,0.043216735,0.033987075,-0.014196812,-0.036172085,-0.103712685,-0.04399591,0.0026175864,-0.0062630586,-0.034876525,-0.08374492,-0.0027308671,-0.0054562553,-0.039009456,-0.033858757,-0.059080187,-0.04096517,0.038708936,0.01306353,0.03350126,0.11289587,0.014997342,-0.03301074,0.042119917,-0.0455601,0.013517731,-0.018331856,-0.1253217,0.015939144,-0.0048144883,0.00073007634,-0.029566918,0.09221727,-0.017803555,0.045513663,0.012518174,0.06066606,-0.044306807,-0.02260422,-0.13242123,-0.057327628,0.014145616,0.030881705,-0.040926676,-0.0017941789,0.0598954,-0.035512537,-0.03726375,-0.05211118,0.07818414,-0.07973376,0.005957863,0.04048589,0.03567616,-0.024318233,0.042024367,-0.041380525,-0.028664593,0.004194374,-0.06928738,-0.05023424,0.042281475,0.053221572,0.052469175,-0.013908055,-0.09052976,0.024938205,-0.09343482,3.387435e-34,0.070471674,-0.10637337,0.13296358,0.045704234,-0.050664276,0.0022430653,-0.018415669,0.010387969,0.008462849,-0.016363667,0.023094097,-0.00506607,0.024461942,-0.06863836,0.028578622,0.0615565,-0.024648733,0.05826705,0.03596824,-0.0072846175,-0.013257806,0.03745927,0.009513647,-0.06832995,0.002222848,0.10509716,-0.03478305,-0.0071283886,-0.022896597,0.038931627,0.04023452,-0.008106563,-0.096998,-0.11810489,-0.064524435,0.007361762,0.020861626,-0.05550265,-0.025600143,-0.05672656,-0.04416101,0.017708728,0.042578284,0.073351346,0.07358903,0.021330962,-0.017030807,-0.009731143,0.011369047,0.04832728,-0.006901632,-0.039058246,0.041448306,0.033427317,-0.015892366,-0.01388153,-0.045764133,0.019171795,0.039792407,0.016446315,-0.01038336,-0.017638197,-0.002166323,0.043350462,0.02290515,0.10276202,0.0358479,0.0111524835,0.04959969,-0.03694224,0.04352562,0.031632286,0.01390899,0.06229888,0.11071809,0.054924153,-0.07552177,0.01430243,-0.021377249,0.015171103,-0.09139945,0.0415366,-0.012701323,-0.03375009,0.11284219,0.027144017,0.021873228,0.12817071,0.049440112,-0.01055913,-0.054725237,0.005405841,-0.073528,-0.016652975,0.09297799,-1.5645629e-08,-0.003338468,-0.106214374,-0.043500796,-0.08777199,-0.012674257,0.105404444,0.023489127,0.012763817,0.040615655,-0.028058875,0.05086085,0.07301766,-0.017197192,-0.038599472,-0.039265454,0.090929836,-0.048622463,-0.060899526,0.0011158604,-0.01513412,-0.002315542,-0.015827922,-0.027380863,0.13333037,-0.021454528,-0.047546227,-0.0027854005,0.102786586,-0.069596514,0.045897093,0.017859912,0.011617134,-0.011615096,-0.07184157,-0.02573352,0.020633103,0.022251131,-0.009540431,0.00053010567,0.019964209,-0.021131504,0.014211114,0.04795101,-0.022736378,0.025577137,-0.021453252,-0.07966036,0.10675983,-0.014048654,-0.008758724,-0.0063252007,-0.04189497,-0.02293723,0.015762383,-0.14014581,-0.04508896,-0.024973728,-0.0705919,-0.034929458,-0.017417971,-0.07495315,-0.048773255,0.08562593,0.027980573 +1.2.3.9,"Acts on benzaldehyde, vanillin and a number of other aromatic aldehydes, but not on aliphatic aldehydes or sugars.",384,0.99999994,0.017888445,-0.11008643,-0.04089202,0.010347162,0.08955543,0.049254157,0.042828955,-0.076192565,0.07277966,-0.0075520207,0.050713293,-0.017916972,-0.078811035,0.013932591,-0.031118203,0.032450363,-0.06260188,-0.023269353,-0.049102437,0.035661638,-0.0072704945,-0.032789648,0.044240225,0.011845134,0.03341104,0.0062483856,0.008311537,0.064536415,0.0061534485,-0.08014702,0.008461382,-0.0092871925,-0.11689824,-0.012839824,0.02563007,-0.0075491294,-0.052938752,0.023031445,0.09008654,-0.015268902,0.054988,-0.11487088,-0.072561696,-0.038890734,-0.02311093,-0.007868549,0.014339558,0.01325839,-0.05692759,-0.0066750096,0.007506743,-0.0030507608,-0.013356489,0.034569938,-0.057537254,-0.055252753,-0.051203087,0.026076915,-0.040030297,0.0064385817,-0.08101496,-0.02070828,-0.017148247,0.03507542,-0.08357761,-0.0221498,0.016272726,-0.007869882,0.01620974,-0.048996896,-0.039912794,-0.066612005,-0.013757895,0.050202135,0.083047114,0.012639392,-0.036471747,-0.049833108,-0.012847732,-0.06560041,-0.031482384,-0.010206574,0.058933206,0.0700589,0.020544654,-0.077204704,0.011791816,0.03375074,-0.029245459,0.099606015,0.016956458,-0.025755811,0.020049673,0.017345337,-0.030317614,-0.003727408,0.1051778,0.008863613,0.071598925,0.019318484,-0.07234909,0.03750967,-0.047586393,-0.083344065,-0.01986834,0.03360526,0.00918311,-0.036230344,-0.011628835,-0.07393763,-0.003486046,-0.03008878,0.06531075,-0.016650891,-0.058780342,-0.011131625,0.07903745,-0.061884407,-0.09690991,0.002063626,-0.050759107,-0.013704964,0.019154126,0.07078695,-0.0431758,0.048106,-0.064530365,1.1922148e-33,0.031668536,-0.054850172,0.010071655,-0.05690135,0.097065166,-0.0017242478,-0.12627588,0.059993364,0.032690916,-0.003510427,0.0032301552,-0.068860196,0.012595187,-0.019871633,0.011463996,0.08902536,-0.025638849,-0.048587937,-0.0066295043,-0.057663087,-0.045118388,0.029700592,-0.09661227,0.020777829,-0.053922776,0.050069917,-0.058524206,0.032792494,-0.045153625,-0.015061995,0.06715839,0.010877987,-0.061430685,0.014853361,0.0050212713,0.09226015,-0.047649406,-0.018348193,0.0069141765,-0.086197436,0.03845796,0.057027634,-0.013327687,-0.08886737,-0.08909787,-0.0033298982,-0.0358093,0.11940982,0.07062502,0.034857202,0.08521508,-0.035556696,0.06875294,0.045075744,0.0003469648,0.10300563,-0.01883625,-0.022514496,0.061284304,0.023180725,-0.002994314,-0.0031162908,-0.04236095,-0.081676185,-0.021854086,0.008215677,-0.033599794,0.029644758,-0.04321902,-0.054037638,-0.046716206,0.01395461,0.09063557,-0.011137114,0.021885194,-0.009378644,-0.06331693,-0.008355869,0.074681036,0.082223274,-0.0015628977,-0.0705223,0.035785448,-0.095646404,-0.11307181,0.03629981,-0.051996827,0.020541383,0.0056973915,0.036367588,-0.030475888,-0.05150834,-0.025341706,-0.015768502,-0.022811305,-6.0787355e-33,0.022125788,-0.047162797,0.029410228,-0.010388475,0.029299876,0.03037433,-0.043578085,-0.03992979,0.014569363,0.018967671,0.08577964,-0.0059936494,0.026814569,0.031991348,0.013563731,0.023482855,-0.008601875,0.07281585,0.028766703,-0.036338273,-0.07377971,0.095531106,-0.04294416,0.04136504,0.034133077,0.021037254,-0.010847618,-0.019182246,0.05293269,0.04767426,0.004360653,0.004068934,-0.014105998,-0.12085746,0.044992767,0.011694058,-0.015638325,-0.0020817048,-0.090602815,0.0533909,0.024584746,-0.04193705,0.03901121,0.089463845,0.07782166,0.057770565,-0.09133806,0.01358573,-0.044685967,-0.030398251,0.0373447,0.09434487,-0.038687594,0.05208473,0.04715393,0.15794072,0.03005274,-0.075432025,0.0035868622,-0.059256412,-0.04340318,-0.000120166755,-0.055234533,-0.09654,-0.052737698,-0.0056063416,-0.07502925,0.032668117,0.107983194,-0.0770539,0.07212678,-0.02821043,0.0072522652,-0.021782547,-0.07034422,-0.0704012,0.03540594,-0.023972416,-0.029833924,-0.06929972,0.0032604823,0.017528147,0.011821137,-0.022627268,-0.070622005,-0.02353312,-0.020575663,0.023779077,-0.0599713,-0.0027900427,0.004424466,0.06376868,0.055569623,0.0646555,0.017502887,-3.130429e-08,-0.018049989,0.023788488,0.11294264,-0.003992394,-0.040030275,-0.0236822,0.088349774,0.0651281,-0.04381218,-0.018329475,0.021227244,0.068884544,0.02116905,0.037491053,0.04125152,-0.04680932,-0.050015517,0.041953363,-0.044637542,-0.014420152,-0.12064934,-0.0003579854,-0.041140307,0.056469608,-0.043724775,-0.04911442,0.04041158,-0.03836578,-0.026614094,-0.02974061,0.07637721,0.13162227,0.029972138,-0.061183397,-0.04394404,0.018118087,0.005119309,-0.09601178,-0.025144596,-0.021526154,0.0028441858,-0.075737655,-0.07112723,-0.00883105,-0.0016321597,0.021557027,0.017847119,0.034383994,0.028480435,0.03151233,0.09982367,0.037426945,-0.00152539,0.035918415,-0.011938458,-0.0051426063,0.036307175,-0.03146425,0.1216697,-0.044523124,0.08289343,-0.00356524,0.114549205,-0.02044901 +1.2.3.11,"May be the same as EC 1.2.3.1, aldehyde oxidase.",384,1.0,-0.056525245,-0.036180668,-0.050280504,0.045737125,0.12319438,-0.028287604,-0.022957884,0.029538332,0.05991064,-0.09689702,0.09158566,-0.042916387,-0.07378518,-0.00051275204,-0.044361975,-0.0034122947,0.0032969306,-0.060498927,-0.040502213,0.018888732,0.037794303,0.049080476,0.03277727,0.0341612,0.06485981,0.0032549882,0.023200724,0.05563076,0.008037958,-0.097574234,0.07528841,-0.029776284,0.045916952,-0.050166383,0.022417935,-0.023700956,-0.0006840069,-0.11851776,0.00056953344,0.03131965,0.04706353,0.021209996,0.027389297,-0.03237791,-0.008066404,0.0059338463,-0.01693216,0.031536862,-0.036047686,0.028014932,0.07866529,-0.107009165,-0.08397642,-0.0057136896,0.06039659,-0.0017437724,-0.07969198,0.024759324,-0.043023903,0.07487835,0.03768612,0.027965842,0.0064101443,0.021584054,-0.018651035,-0.03531174,0.09677371,-0.16171116,-0.0042873346,-0.06476918,-0.11712679,-0.1072262,0.03559822,0.04689616,0.04040843,0.054218575,-0.020475946,-0.07817609,0.02099007,-0.04056425,-0.048299205,0.0033196274,-0.049286675,0.046351317,0.024013832,-0.01466602,0.033228405,-0.045188997,-0.0046274234,-0.008691344,0.005847036,-0.01839004,0.021282462,0.07914953,-0.04770277,0.07208799,0.08152928,0.16935743,0.0077357693,-0.004337655,-0.06472152,0.086956725,-0.028619742,-0.05291851,-0.03081268,-0.0025287378,0.048443824,0.04357128,0.0071630785,-0.03420406,-0.014496872,-0.08523479,-0.0061769253,-0.028959876,-0.030811956,0.018185092,0.02794239,-0.03633497,0.03302046,0.0541717,0.075368635,-0.050617162,0.057877317,0.039306145,-0.049890764,0.026827881,-0.078123674,-4.531382e-34,0.018541861,0.036025766,0.042505454,-0.0042780507,0.01735072,-0.014681591,-0.11413432,0.050884318,-0.050427742,-0.018202998,-0.0734689,-0.005148505,0.040989447,-0.01496937,-0.03686163,-0.05573954,-0.076049045,-0.017344005,0.009256038,0.0009123925,0.015835386,0.0025808022,-0.044286523,0.025739959,0.027796287,-0.031355526,-0.0102109825,-0.047575977,0.056189243,0.0013592007,0.021909487,-0.047661755,-0.069216736,-0.045416407,-0.11496209,0.02198469,0.0001926647,-0.03920445,0.008321475,-0.013414213,0.042914685,0.04300214,0.062713265,-0.07674348,0.019647308,-0.04950742,-0.070195906,0.10418581,0.099545754,0.018052503,-0.016134989,-0.024180051,0.09961776,-0.012303986,-0.029798469,-0.0043302146,-0.015043492,0.081230186,0.03455927,0.04974426,0.018876031,0.120447226,-0.02775999,-0.0077433013,-0.013280559,0.024728412,-0.05131399,-0.025721502,-0.010975253,-0.0092170965,-0.0608397,0.029813575,0.09726855,-0.0033927325,0.04472226,-0.048488986,-0.08877145,0.047132235,0.030223174,0.015893454,-0.13209715,0.019832771,0.026704183,-0.018902235,-0.09463293,0.0006153962,-0.0278434,0.06703619,0.015878808,0.056643523,0.025967302,-0.0046579516,-0.033028215,-0.0035552697,-0.06807791,-8.95249e-35,0.023790317,-0.060543742,-0.021570321,0.0025308758,0.04352117,0.026000004,-0.010646508,0.06759531,0.042959023,-0.012948219,0.14858404,-0.018031169,0.026147917,-0.07123786,0.09062706,0.0026920757,-0.08376609,0.026149208,0.019563528,0.045777265,0.0094011715,0.0381067,0.008765384,0.04102701,0.054454133,0.022054488,0.045840632,-0.007975875,0.057562634,0.02414992,-0.08436061,-0.0115631865,-0.03990321,-0.01178672,-0.039098185,-0.011769933,-0.021812286,-0.08303964,-0.02830819,-0.00054066785,-0.004435578,0.028101273,-0.018281877,0.063315324,0.04981658,0.10224571,-0.004596325,0.03539674,0.046988852,-0.026991704,0.023736091,0.0036774056,-0.06952246,0.04047539,0.016714962,0.08282336,-0.027119163,0.044389483,-0.010931362,0.009010521,-0.0033509047,0.015123353,0.04480938,-0.02508025,0.015176618,0.038157035,-0.09638985,0.061579753,0.042916078,0.015289958,0.113775894,-0.015909081,-0.041637894,-0.050301187,-0.0050916597,-0.123003274,0.015056383,0.02287017,-0.021958638,-0.03463308,0.03577756,-0.004173549,0.012311572,0.02143641,0.018141268,-0.03152493,0.0029135563,0.113962226,-0.021763654,0.011152399,-0.07623852,-0.0102226045,-0.1036326,0.085795626,0.008601274,-2.2764578e-08,0.031638566,-0.04222205,0.0782536,-0.03882397,0.040369116,0.028970253,0.044553753,0.027906591,0.005284071,-0.0019425302,0.027397435,0.05915958,0.020253887,-0.017946051,-0.00405189,-0.03141143,-0.07948576,0.07129208,0.0006280906,0.023623787,-0.029717432,0.024622431,-0.02060943,-0.05844534,-0.011507212,-0.022411996,-0.012139954,0.02037399,-0.017575238,-0.07314547,0.017505746,0.06310125,0.04800056,-0.043981638,-0.051244233,0.04272743,-0.03760406,0.015167767,-0.09168278,0.057273556,-0.029842872,-0.13086478,-0.042850353,0.0044016987,0.07625686,-0.0036434147,0.03523511,0.0046325033,-0.016960312,-0.11404967,0.029798867,-0.019399721,-0.018950203,-0.021422107,-0.08341635,0.007625569,-0.053479,-0.08333677,0.03420401,-0.06638558,0.04171301,-0.001608478,0.15995657,0.06591869 +1.2.3.13,Involved in tyrosine degradation pathway in Arthrobacter sp.,384,1.0,0.005349701,-0.015636379,-0.061251674,-0.0021464652,0.026252551,0.0029955246,0.02665843,0.087693505,0.031120634,0.051978666,-0.04701493,0.009788602,-0.027702156,0.05918886,-0.01777827,0.11543402,-0.08182558,-0.011747934,0.026314091,-0.031887293,-0.022268925,0.025020614,-0.012252961,-0.033763047,-0.07373949,-0.039814293,0.031306513,-0.05524752,-0.076951414,-0.03163126,-0.013485781,0.026643733,0.056085933,-0.06277967,0.068545654,0.08996221,-0.05766956,-0.07512188,0.029475192,0.024598759,0.021416722,0.055188697,-0.11708816,-0.04642856,-0.014217559,0.024939293,0.002639235,0.008663941,0.03931224,0.0592353,-0.063232206,-0.027460705,0.007817557,-0.0124584725,0.0018184333,-0.013086011,-0.010357738,-0.021576993,-0.07563293,0.044227745,0.050668027,0.0412589,0.057301473,-0.036837224,-0.02676374,0.008121836,0.036138475,-0.0127086425,-0.044386696,-0.025199821,-0.11381677,-0.031283315,-0.037199307,0.058910478,-0.030125264,0.005959406,0.0046819793,-0.037783645,0.02297766,-0.08727063,-0.050616276,-0.047663648,0.015787106,0.06396803,0.007089044,-0.0029902863,0.008780329,-0.062940724,0.08767404,0.082612336,0.062820025,0.016826421,0.04042176,-0.056040227,0.021356156,-0.037980955,0.04191464,0.042840436,-0.012448426,-0.015947452,-0.08576147,-0.0013017592,-0.045197237,-0.03889696,-0.035056718,-0.007934007,0.019283086,0.09839311,0.013292018,0.04964668,-0.003493652,0.043114275,0.090669096,0.0076244893,0.0056953686,0.006966606,-0.017826678,-0.0064766086,0.009758926,0.015950322,0.0006985858,-0.021180524,0.0683186,-0.00835103,0.03579898,0.026292054,0.05479073,-8.750455e-34,0.06835315,0.025143668,0.040504556,-0.0030546158,0.010650404,-0.043345265,0.0037998648,-0.038872328,0.059668142,0.005320506,-0.040252555,-0.11902511,-0.0043752245,-0.0020093806,-0.0091583,0.077682376,-0.06280868,0.038457684,0.0022919,0.070608586,-0.0208841,0.07925724,-0.05150201,-0.022062272,-0.030788574,0.13431895,-0.05096001,-0.017518105,-0.07733755,-0.024995316,0.07435663,-0.007660824,-0.09633333,-0.0070836074,0.049078174,-0.013730376,0.02485987,0.042413075,-0.053772435,-0.055282198,-0.008192072,0.04580393,0.021961592,-0.022869578,0.07780274,-0.0691414,-0.033071436,0.11347239,0.006415756,0.015392195,0.043916956,-0.031243278,0.09893803,0.06289492,-0.014039759,0.0004593778,-0.047059588,-0.08771203,0.08512593,0.06334287,0.07880186,0.008329775,0.019531509,0.03430301,0.06888806,-0.037667993,-0.07471343,-0.03580289,-0.032128554,0.033793002,0.004460484,-0.09537079,0.07729808,0.058497243,-0.038391557,0.023810165,-0.094281726,-0.016950957,-0.011028734,-0.06765394,-0.01865951,-0.009031344,0.06382616,-0.031487584,0.02774239,0.06082617,0.03428751,-0.0670852,-0.02719438,0.04871318,0.027783077,-0.06346733,-0.12446588,0.023074081,-0.00915876,-1.2263483e-34,0.08492706,0.016924886,-0.057623252,-0.057514913,-0.052332662,0.0038050476,-0.040885523,0.08449674,0.030013153,0.015335032,0.10841468,0.025779553,-0.020121159,-0.069767185,0.008165383,-0.061531205,0.0872244,0.059141148,-0.1021198,-0.06681513,-0.046648707,0.03507343,0.014162465,-0.0651495,0.007359987,0.021702426,-0.055854026,0.1267167,0.032279287,0.034840018,0.038190667,0.03920671,0.014787909,-0.030739514,0.039018467,-0.008501189,-0.09010595,-0.07786971,0.07722815,-0.029020552,0.08291172,-0.07830967,0.00019102728,0.012331805,-0.0037465482,0.081213504,-0.13989441,-0.033062927,0.03349133,-0.016737385,-0.009728132,-0.06522554,0.0072030076,-0.07344944,-0.021600123,0.060074214,0.019340329,-0.04775787,-0.06072035,0.060043763,0.048373386,0.0885621,0.12275206,0.04777016,-0.02606215,0.045933485,0.021485152,0.12666889,0.06085833,-0.0023173334,0.021784246,0.07851001,0.07432948,0.050988305,0.0067854533,-0.08331079,-0.10255814,-0.023234092,0.075613126,-0.06811281,-0.06360644,-0.006490201,-0.04061704,-0.04812617,-0.04037356,0.0025937965,-0.08811329,0.028327156,-0.025672391,0.034762546,0.00673658,-0.066257365,-0.051219072,0.021081686,-0.032993387,-2.0331376e-08,0.01314229,-0.00075990625,0.07042642,-0.047314774,-0.052846853,0.025103206,0.015807196,0.082687184,0.07041256,0.012794645,0.047910996,0.037873358,-0.027474897,-0.043832477,-0.015206929,-0.023982108,0.015538236,-0.0018351192,-0.046054013,-0.09530916,-0.058269497,-0.024747536,-0.00032329734,-0.039293464,0.07844435,-0.090813994,0.0066881133,0.015012861,0.009531294,0.0077645835,-0.0009504844,-0.006759308,0.038938582,0.048964214,0.023543412,0.005489814,-0.07559875,-0.049276546,-0.007816214,0.056277085,-0.07040141,0.0742601,-0.13435225,-0.009892506,0.038294904,0.016740438,-0.0150467055,0.017139258,-0.07105183,-0.023097439,0.028680526,0.05743278,-0.014458683,0.0013090842,-0.10272795,0.02355613,-0.0054871975,0.0058589834,0.00170992,-0.021532062,-0.01646429,-0.044206716,0.08155755,0.006211525 +1.2.3.14,"Acts on both (+)- and (-)-abscisic aldehyde. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.1.1.288, (xanthoxin dehydrogenase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.14.137 [(+)-abscisic acid 8'-hydroxylase]. While abscisic aldehyde is the best substrate, the enzyme also acts with indole-3-aldehyde, 1-naphthaldehyde and benzaldehyde as substrates, but more slowly [3].",384,1.0,-0.038640514,-0.07435931,-0.10336928,-0.0425193,0.12042932,0.04128504,-0.08380484,-0.01959281,0.058746967,-0.0005058968,0.113860734,-0.055547155,-0.005626679,-0.029372623,-0.037599754,0.08597018,-0.06845417,-0.018088775,-0.0069200066,-0.028382398,0.02684435,-0.0032111017,-0.019592337,0.004440863,0.10236987,-0.059947122,-0.034822416,0.0033200833,-0.010327191,-0.069056764,-0.03207752,-0.039243456,0.032803237,-0.0070076543,0.0071136067,0.08871562,-0.023198402,-0.00058335764,0.09388486,-0.02579397,-0.0090882145,-0.047222733,-0.04133449,-0.04321501,-0.062373854,-0.017532224,0.033824913,0.02731877,-0.030483807,-0.021295808,0.0013905084,0.032017007,0.0037735961,0.0002692713,-0.032998152,-0.05444052,-0.0291124,0.09186994,-0.03905273,0.040470365,-0.008537124,-0.03676873,0.0069165565,0.032616388,-0.031035248,-0.04238476,-0.017450642,-0.05160358,-0.006428366,-0.043862954,-0.058914594,-0.082609855,-0.037285298,-0.011391898,0.040893577,0.026918702,-0.04057271,-0.013999513,-0.01948215,-0.03639686,0.049708,0.04602828,0.03163261,0.052998547,0.026149618,-0.060458373,-0.0024617293,0.06975977,-0.041224916,0.06907637,0.075065985,-0.0019007481,-0.029460827,0.018739466,-0.012396201,0.089186914,0.10230138,-0.008791756,0.014920599,-0.07364781,-0.053538956,0.103251986,-0.07815778,-0.029608456,-0.020655952,-0.047739115,-0.03378375,0.04687572,-0.046770338,-0.061349645,-0.012464164,-0.06663771,0.030876108,0.0108365305,-0.02173205,0.04074042,0.058054335,-0.0758372,-0.022748597,-0.046528976,-0.047830787,0.04736686,0.051824674,0.10393897,-0.022723649,0.063607454,-0.08726114,1.2027423e-33,0.05168198,0.041990165,-0.1304633,-0.07119764,0.049928743,-0.024501625,-0.08259608,0.06655482,-0.03940514,-0.01599064,-0.020899195,-0.052778356,0.070258856,-0.023251478,0.028813917,0.010066222,-0.03691902,-0.06995942,-0.00022031774,0.035951998,-0.017203083,-0.03598395,-0.11349155,0.026310327,-0.020530893,0.04553545,-0.0096723465,0.03680886,-0.069768175,-0.0376678,0.009876582,-0.06081581,-0.070710614,0.022673907,0.047434393,0.027111065,0.015332955,-0.016386738,-0.04681746,0.03511653,-0.031697076,0.09161626,0.019684488,-0.10106104,0.08124355,-0.041180138,-0.07373223,0.107377075,0.07699398,0.059990615,0.0666209,0.05080675,0.15071042,-0.052173257,-0.027773416,0.046321984,-0.037269868,-0.0063543804,0.0135568585,0.028826594,-0.06004307,-0.017024655,-0.03275957,0.00825698,-0.004364539,0.015699344,-0.07571629,-0.050205722,-0.012368505,0.059870113,-0.06673185,-0.060244128,0.06848452,-0.04113184,0.0038005218,0.019944983,-0.08954381,0.036753263,0.032650594,0.04878962,0.0077054203,0.059642848,0.09852528,-0.07585779,0.0029281932,-0.025012055,-0.045693133,0.009095336,0.026332526,0.051986445,-0.01259229,-0.047840707,-0.015982218,0.028884206,0.03692196,-2.6601658e-33,0.14058867,-0.0659907,0.052195337,-0.050629187,-0.027482823,0.10943711,-0.04329446,-0.0044730203,0.054412298,0.013155217,0.02955301,0.05204388,0.022972818,0.030818906,0.05394052,-0.01800862,-0.01234335,0.081331246,0.009015102,0.0009040445,0.022237929,0.1406242,-0.009417681,0.020863269,0.05241873,-0.024731325,0.0036766895,0.0540974,0.0081355795,0.0022524917,-0.039862726,0.00033418465,0.0026462395,0.014985426,0.03537227,0.06310872,-0.12413299,0.03981402,-0.045881946,0.10011152,0.012312183,0.029004272,-0.06308055,0.053770278,0.06217715,0.043626282,-0.118998975,0.008142032,-0.022573853,-0.05164761,-0.008412606,0.043001298,0.025656637,0.029223807,0.049307227,0.043340538,0.010935448,0.014678147,0.006907623,-0.028035587,-0.026515732,-0.050022088,-0.011791835,-0.035699297,-0.030746985,0.031760845,-0.0052591893,0.037546054,0.0037787016,-0.0023350874,0.10132965,-0.011720663,-0.009659178,0.06113924,-0.03534205,-0.021406267,-0.006757475,-0.05740028,-0.0015180076,0.033212382,0.034775782,0.05525477,0.00082708604,-0.02131203,-0.036808774,-0.0064485157,-0.027757134,0.07517265,-0.029994017,-0.012610903,0.010424379,-0.0222948,0.006305013,0.008492827,0.087953456,-4.317291e-08,-0.0104154805,0.017017337,0.06369687,-0.03601762,0.0072957515,-0.026254011,0.02725375,0.005812733,-0.027309977,-0.0581352,-0.016151473,0.018024184,0.020614913,0.038662758,0.05718044,-0.03755219,0.053577874,0.038679235,-0.029290494,0.09107061,-0.09388359,-0.004631438,-0.09285639,0.011349885,0.027347632,-0.09210145,0.04262523,-0.019622069,0.036269788,0.038207117,-0.018595884,0.05818799,0.041130766,-0.022674631,-0.1120365,-0.012934548,-0.003916131,-0.06282891,-0.06722999,-0.00050392264,0.037461307,-0.11284243,-0.020574268,-0.018231679,0.013505868,0.0154371625,-0.008978226,-0.02513842,-0.016406527,0.00872245,0.06860469,-0.08041269,0.083966196,-0.060361452,-0.061736356,-0.02446493,0.005357422,-0.064077936,0.014236488,-0.010752421,0.02988227,0.06611012,0.22610451,-0.050929103 +1.2.4.1,"Contains thiamine diphosphate. It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex, EC 1.2.1.104, in which it is bound to a core of molecules of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.",384,0.9999999,-0.088647924,-0.009729019,-0.07355252,-0.057538904,0.08825976,0.017066967,-0.008588557,0.03619411,0.004368838,-0.018442852,0.06379944,-0.07607675,-0.058341768,-0.069870286,0.033125963,-0.027083775,-0.030173618,-0.07129948,0.0028104843,-0.043310948,0.08659797,0.10254508,0.012331405,-0.015863802,-0.02958872,0.081701435,0.07123759,0.011902535,0.0378123,-0.09284174,-0.020109057,-0.008044213,0.0518153,-0.050313257,0.029986309,0.14390592,-0.03196484,-0.028844053,0.04541047,0.039003037,0.08541203,-0.008335655,-0.026888564,-0.013645886,-0.022311151,-0.020230697,0.049262185,0.059629817,-0.036256354,0.018004565,-0.022087026,-0.028534228,0.039669145,0.04643595,0.033672713,-0.011565929,0.008152146,0.0257583,-0.09264103,0.031306766,0.020811105,-0.030732887,0.02475183,-0.025645824,0.024183927,-0.072671376,0.10279808,-0.13201891,0.027797563,-0.08302137,-0.11532386,-0.04843567,0.07114518,0.056133743,-0.007968443,0.051330537,-0.014444006,-0.027635524,0.041027885,-0.081191584,0.04161966,-0.058045525,0.0034591462,0.037081324,0.02250175,-0.05621318,0.0057939203,-0.07083112,0.010150403,0.018679932,-0.0004309275,-0.026213402,-0.0059785773,0.013010344,-0.05735519,0.079624906,0.029758133,0.054664623,0.000218011,-0.035258222,0.034320954,0.0872851,-0.082501575,0.012833878,-0.069837086,-0.03492052,0.032193515,0.0030312652,-0.0610533,0.008426385,0.0073469062,-0.028507693,0.08878254,0.01572993,-0.0074741305,0.0021404198,0.001671302,-0.053302128,0.00348209,-0.006912248,-0.0025616311,-0.03652854,0.098239906,0.077700436,-0.067289814,-0.002274408,-0.13979389,4.6795302e-33,0.07419074,0.04197628,-0.0057892827,-0.029448843,-0.04999937,0.009843774,-0.09899564,0.024043646,-0.048278127,-0.00017377746,0.013751286,-0.06855355,0.07651657,0.03999094,-0.06124436,-0.0762695,-0.018580081,0.04542494,0.105241634,-0.05561463,0.0056531234,0.057959996,-0.060014144,0.011104732,-0.018504826,0.054282792,-0.03012198,0.04394334,0.06388302,0.002369272,0.036011912,-0.06057597,-0.05163593,-0.018123029,0.04912912,-0.035776485,-0.050472148,-0.03190722,-0.061517783,-0.01597111,0.017874032,-0.0031742225,0.03655418,-0.052597366,-0.048772994,-0.09218551,-0.026147487,0.06563752,0.055249523,-0.029095223,0.015725777,-0.04797588,0.14589746,-0.082614966,-0.028045183,0.00583743,-0.020547122,-0.0039141555,0.06592583,0.082990125,-0.022389378,0.04497648,-0.08238499,0.0039053902,-0.005273358,0.044146243,-0.13559435,-0.051283695,0.009342131,0.020700162,0.008551883,0.003914847,0.1150996,0.014487627,0.028178334,-0.0035367517,-0.061298497,0.06526779,-0.05062173,0.025372952,0.013676653,-0.0006322625,0.03708335,-0.05570471,-0.046880458,-0.01704429,0.003295724,-0.07344312,0.020730102,0.024839144,-0.024332052,-0.0334716,-0.06374994,-0.010662481,0.023560641,-5.7810202e-33,0.032855876,-0.015798049,0.022689268,-0.07436205,0.013623502,0.08216175,0.04414821,0.021196885,0.022142254,-0.05896655,0.081230044,-0.013964467,-0.0021846725,-0.086170025,0.035081405,0.11164616,-0.05952049,0.01935725,-0.001374417,-0.03137279,0.0054941177,0.011039477,0.03648183,0.08503223,-0.018901391,0.030112997,0.0098867845,0.012851466,-0.00498102,0.066335656,-0.038181793,-0.0018489464,-0.11095368,0.0015568417,-0.1103857,-0.038770072,-0.076252244,-0.07790602,-0.04296451,0.0333449,-0.005879507,0.03830158,0.050833415,0.045131058,0.072476715,0.07786315,0.00081476883,0.021524267,-0.032646958,-0.004195859,0.018213952,0.018511668,-0.012173303,0.061757084,0.10143432,0.06967962,-0.01375431,0.053328954,0.06758565,-0.08091231,-0.0027065128,-0.07506257,-0.0009489673,0.021520702,0.083436355,0.012403216,0.0050666,-0.003344912,0.07388532,0.058522485,0.054581977,0.011878255,-0.002674338,-0.06734694,-0.012649168,0.046409663,-0.04705947,-0.024194367,-0.059526104,-0.030550327,0.04596224,-0.05811195,-0.048912995,-0.09027806,-0.0043418356,-0.020356048,0.0095635075,0.04953465,-0.036465038,0.014771534,-0.0684948,-0.008078579,-0.0712185,0.068451576,0.106970154,-4.8642267e-08,0.044249065,-0.066728726,-0.0017163524,-0.041353665,0.031066151,0.013236182,0.035710804,0.04594881,0.07809185,0.025110865,0.048599433,0.05319874,0.03710157,0.016505398,0.044705786,0.012033913,-0.0173961,0.071442,-0.011885255,-0.047882047,-0.0023545984,-0.05267026,-0.049893077,-0.00046713508,0.016941488,-0.07073303,0.04080623,-0.027826805,-0.023860458,-0.057886995,-0.009635651,0.023416441,0.010373042,-0.08524429,-0.014227489,0.038435843,-0.02825626,-0.012969386,-0.057563115,0.09436369,0.025933135,-0.037639752,-0.11527869,0.044964716,0.026145082,0.061557304,-0.014685374,0.07096939,-0.061879758,-0.037976783,-0.0620916,0.03913657,0.016338611,-0.020316742,-0.08150101,0.01574067,-0.058934826,-0.023962462,0.047205057,-0.007601723,0.046522845,0.017709559,0.14360328,-0.05283139 +1.2.4.2,"Contains thiamine diphosphate. It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex, EC 1.2.1.105, in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, dihydrolipoyllysine-residue succinyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.",384,1.0,-0.09019598,-0.019984685,-0.05087945,-0.05814341,0.08606459,-0.016719772,-0.0053981417,0.04147087,-0.012559354,-0.028141329,0.066891424,-0.0852133,-0.028905505,-0.05267564,0.019458916,-0.015356102,-0.033334162,-0.054160256,-0.026801275,-0.039069023,0.08740254,0.11163781,-0.01962732,-0.013176709,-0.033600666,0.10509701,0.036700316,-0.016703486,0.019183751,-0.1111622,-0.028030446,-0.009669505,0.048083086,-0.059297662,0.03276016,0.09701599,-0.031274285,-0.033429235,0.06292633,0.06385935,0.06815895,-0.032001898,-0.019985372,-0.04353168,-0.021476666,-0.041422296,0.04202916,0.046763048,-0.0001822527,0.03448261,-0.03240205,-0.049754377,0.054473244,0.0338284,0.032809444,-0.03115707,0.010989278,0.027312694,-0.08618642,0.05722476,0.026099637,-0.024690384,0.018340137,-0.02070567,0.051762998,-0.07620138,0.09533776,-0.13055395,0.037322834,-0.07008385,-0.10032895,-0.043585002,0.04826934,0.07397817,-0.006592798,0.06212861,-2.665061e-05,-0.03858684,0.05557074,-0.07840527,0.06383961,-0.05675857,0.025751261,0.05920386,0.03564183,-0.052841604,0.007117562,-0.046453785,0.02188792,0.014613056,0.009791351,-0.02405066,0.006530779,0.01861409,-0.0422501,0.08968662,-0.008095668,0.08099649,-0.01633334,-0.02408585,0.03274292,0.05671738,-0.07735516,-0.003923836,-0.042329278,-0.035371978,0.023996165,-0.007986219,-0.07512748,0.010693565,0.023536017,-0.054665804,0.08097184,0.01283517,-0.018402867,0.034618404,0.02662663,-0.03444989,-0.015305815,-0.06178285,-0.00712197,-0.031026999,0.11032285,0.078822106,-0.048164,0.0049190302,-0.13828984,5.1271445e-33,0.06889653,0.04386103,0.0033051278,-0.01720169,-0.053105857,-0.0042098733,-0.09103729,0.046032757,-0.05370544,-0.010366261,0.016045831,-0.05759607,0.067412056,0.01858724,-0.041178692,-0.08794119,-0.0056849583,0.03474656,0.090301454,-0.031774107,0.014639396,0.05904006,-0.077915706,0.0044789994,-0.011301779,0.048058465,-0.038036305,0.016353449,0.064346425,0.012507798,0.050738633,-0.069944605,-0.054626577,-0.020724092,0.04668268,-0.058108836,-0.05350898,-0.029804984,-0.060176194,-0.0022768085,0.014952488,0.0026571017,0.013191059,-0.055314213,-0.033310793,-0.07616244,-0.049478117,0.072344325,0.0626089,-0.024958974,-0.00025145858,-0.039951034,0.1270863,-0.08122094,-0.02520477,-0.021309981,-0.017073346,0.0038292757,0.06887606,0.09011952,-0.038799655,0.04086973,-0.0939134,0.009567634,0.0013151044,0.04022366,-0.13830987,-0.02211198,0.012998694,0.017497698,0.026384389,-0.004966252,0.10817024,0.015588852,0.026271539,-0.014891653,-0.030546077,0.088055335,-0.04586202,0.042599324,0.027020235,-0.003221159,0.024363516,-0.0641397,-0.05350638,-0.007344018,0.016672997,-0.0746816,5.6092555e-05,0.03705346,-0.0067557567,-0.04102287,-0.08927147,-0.018906096,0.020603996,-6.0533852e-33,0.040696155,-0.03420612,0.027979435,-0.07229869,-0.00369321,0.06052523,0.052995782,0.03608535,0.039019875,-0.047180697,0.09551761,-0.00033835685,0.011207579,-0.09272744,0.019430324,0.08432317,-0.074362904,0.009192605,0.0064314236,-0.017740319,0.023622064,0.0124751385,0.06307355,0.09174167,-0.005637599,0.029510584,0.0031044008,-0.0050944504,-0.0049569313,0.071664795,-0.0646924,0.0023773555,-0.08402939,-0.001077391,-0.12230755,-0.050874613,-0.06751039,-0.0696764,-0.03448006,0.02757641,-0.051072408,0.020478409,0.056311194,0.04893059,0.06069646,0.08586012,-0.009965784,0.026440717,-0.03568519,-0.03654788,0.015724625,0.019401992,0.0031529414,0.08415035,0.0659517,0.056227937,-0.012699654,0.066105194,0.06747853,-0.06106041,0.024338542,-0.060294278,-0.021727227,0.003646143,0.08220671,0.02273339,-0.008490496,0.009303639,0.05430571,0.018798271,0.06509268,-0.012640876,0.031185074,-0.072419204,-0.012808133,0.043227058,-0.054108582,-0.028154785,-0.07268706,-0.016691897,0.037820745,-0.04577794,-0.044366583,-0.06598064,0.01388761,-0.0015745602,0.016086036,0.06400676,-0.046015672,0.015197459,-0.094624326,0.018456906,-0.0726312,0.08803515,0.10744282,-4.8845095e-08,0.0337106,-0.0762704,0.0040279804,-0.05595658,0.04118407,0.036531176,0.019220058,0.060871277,0.070646346,0.024084723,0.025041824,0.073745966,0.021709014,0.024324972,0.05137024,-0.007593491,-0.025166728,0.050306164,-0.00596689,-0.046399932,0.0047350735,-0.05997732,-0.036411215,-0.001938363,-0.011078224,-0.044776157,0.051408324,-0.025394004,-0.028139595,-0.06534027,-0.020342251,0.008545415,0.007709193,-0.07708605,-0.016852787,0.03340564,-0.02116756,-0.037336368,-0.080871165,0.08331299,0.02881808,-0.03842223,-0.109869644,0.04821176,0.036162764,0.0401834,-0.009843319,0.09315675,-0.05052869,-0.045950174,-0.058084346,0.027496178,0.019489257,-0.010193036,-0.07843915,0.00021862917,-0.04440022,-0.013383291,0.039668914,0.025396882,0.052578215,0.006273368,0.17032973,-0.041635606 +1.2.4.4,"Contains thiamine diphosphate. It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2-oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine. It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168.",384,1.0,-0.06422789,-0.08010622,-0.0703306,-0.056423776,0.10047303,0.00808978,-0.0618112,0.06748564,-0.0188534,-0.03740271,0.020425731,-0.10340076,-0.03833779,-0.038004987,0.013927109,0.060721993,-0.054703876,-0.00074664183,-0.026251495,-0.036963902,0.093170844,0.042824205,-0.037538603,-0.025220297,-0.049198806,0.10626002,0.017346308,0.009805678,0.005606174,-0.09637241,-0.015366052,-0.039517052,0.017220251,-0.07465678,0.04582079,0.106835715,-0.06334978,-0.06100751,0.028575307,0.07444221,0.090246014,-0.024549613,-0.050221562,-0.024165897,-0.0055679153,-0.053213574,0.023078451,0.012872789,-0.030558303,0.0041847355,-0.008487423,-0.073586956,0.023238188,0.10584103,-0.001864845,-0.007883144,0.034942955,0.05819709,-0.06784141,0.043805134,-0.026783831,-0.0069461176,0.03750734,-0.047245916,0.03393473,-0.04307646,0.04158627,-0.09169691,0.0026202796,-0.11176732,-0.09002179,-0.035524074,0.0073538297,0.0833906,-0.05139842,0.0032761681,-0.0049999463,0.02853117,0.011440252,-0.09784796,0.039631754,-0.062032,0.002636559,0.016364368,0.012621658,-0.050518468,-0.046192575,-0.05317894,0.038278714,0.07870411,0.044853445,0.00664079,-0.040719893,-0.017802812,-0.0021710629,0.04463394,-0.0074968133,0.08535369,0.011479672,-0.015346404,0.01642984,0.06953686,-0.0981288,-0.0032271745,-0.042000122,0.010022236,0.03124843,0.0057972753,-0.07604527,0.016999867,-0.0023196365,-0.0355914,0.08938432,0.026052529,0.0019594785,0.062097568,0.022009447,-0.03431385,-0.038812045,-0.028092787,0.0010212327,-0.028626174,0.15662245,0.04350455,-0.049355693,0.010025147,-0.11586022,5.3424764e-33,0.07350175,0.038438622,-0.009944093,0.0066332812,-0.04773739,0.0049689705,-0.09939929,0.08176947,0.008033062,-0.02403035,-0.03700508,-0.0034567113,0.109732896,0.0061853733,-0.022634694,-0.04896435,0.013402394,0.005029591,0.06918163,-0.023199977,0.053494964,0.035128422,-0.06282932,0.013314486,-0.03891524,0.035634037,-0.0074580414,-0.026904393,0.042960815,0.008282106,-0.0059790285,-0.09042238,-0.055269804,-0.0072198184,0.05660532,-0.026986828,-0.036752816,-0.024662498,-0.039892275,0.04149441,0.0006539303,-0.038287688,4.5837947e-05,-0.053176094,0.0271766,-0.10417092,-0.047213707,0.06551977,0.031617977,0.046072513,0.013709358,-0.09017419,0.08209967,-0.084611885,-0.064782195,-0.025840344,-0.0676321,0.0011417354,0.06275034,0.08763092,-0.019110328,0.072245695,-0.049945038,-0.024629332,-0.019340804,0.028555438,-0.1326059,-0.060124498,-0.0070548574,0.0141333025,-0.00724771,-0.0074300272,0.09293168,0.03487887,0.048555285,-0.04157051,-0.047846247,0.10234745,0.003760125,-0.0026115759,0.011975789,0.011525793,0.047758162,-0.03901709,-0.0076946146,-0.009801242,0.02228572,-0.0814682,-0.04859531,0.03653439,0.040381446,-0.011066338,-0.07449877,-0.016849928,0.07447327,-5.8167277e-33,0.071932584,-0.05070871,0.021752767,-0.089273065,0.01919463,0.06737739,0.02843176,0.046470944,0.029400626,-0.067723915,0.09132129,0.012554519,-0.008784845,-0.10874452,-0.00018980759,0.014934289,-0.039563365,0.054646175,-0.006652955,-0.05807597,0.08207394,0.019796481,-0.0023155562,0.0966438,0.019489232,0.027318746,-0.0071121105,0.0076998835,0.050028067,0.11906895,-0.025715474,0.025822448,-0.029180871,0.04021425,-0.03947979,0.012379489,-0.06678786,-0.025151147,-0.01408513,0.04395508,-0.03210745,0.011410685,0.064507045,0.044787616,0.0395614,0.09475906,-0.10100485,0.003241219,-0.021147039,-0.045012247,0.04821395,-0.014696979,-0.018080128,0.074318975,0.0823291,0.055267915,0.0005109304,0.026154434,0.014941821,-0.045983154,-0.0015852993,-0.037977006,-0.0041218945,-0.021925125,0.065908745,0.031230647,0.04066722,0.02786991,0.05001458,0.0025874346,0.019525036,-0.024062144,0.020757977,-0.077765286,-0.03504253,0.012930217,-0.06231351,-0.015420617,-0.04811261,-0.03822087,-0.0065922556,-0.054026898,0.0066625252,-0.104646504,-0.0064201765,-0.019042108,0.00982816,0.074281365,-0.023802549,-0.010060557,-0.06557641,0.002519238,-0.07806218,0.09124109,0.09985497,-5.977314e-08,0.019815426,-0.081029035,0.03558443,0.004234625,0.033850487,0.057911173,0.01187152,0.038503323,0.07044229,-0.003383525,0.026288968,0.081367865,0.01275281,0.01369862,0.07520035,0.014603185,-0.012615829,0.069713004,0.0007072944,-0.0021539812,-0.012358749,-0.070239305,-0.053550396,-0.0022028608,0.017074926,-0.064785555,0.016461574,-0.006690097,0.02010225,-0.0582929,0.05023765,0.025456324,0.03751255,-0.04527635,-0.055834617,0.04316776,0.0043982165,-0.04122576,-0.089953534,0.070617095,0.018112862,-0.03279198,-0.123530425,0.035433743,0.0954292,0.008977209,-0.010809635,0.08137136,-0.06453314,-0.050891817,0.0014631018,0.0037042664,0.045300744,-0.003958377,-0.08409828,0.033051427,-0.041493896,-0.06289309,0.032145176,0.0013485295,0.043813173,0.016268637,0.1709024,0.007925855 +1.2.7.1,"Contains thiamine diphosphate and [4Fe-4S] clusters. The enzyme also decarboxylates 2-oxobutyrate with lower efficiency, but shows no activity with 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).",384,1.0,-0.008239293,-0.038076486,-0.07409193,-0.023271345,0.08966118,-0.031757783,-0.0868951,-0.0076695527,-0.026774157,-0.023671215,-0.042456854,-0.06610655,-0.037071887,0.024198314,-0.04624457,0.043821454,-0.038411044,-0.052344475,0.05053708,-0.020633701,0.045936186,0.006433427,-0.013780423,-0.028965127,0.015817624,0.050995704,0.041853752,-0.042636003,-0.06721589,-0.10817281,-0.065960936,-0.03860508,0.028008562,-0.007926243,-0.0051511223,0.07092761,0.0038404667,-0.042966824,0.04391209,0.030758236,0.0018076329,-0.007944777,-0.011009184,-0.04751321,-0.039808657,-0.0845916,0.024076633,-0.045124568,-0.015614988,0.052831974,-0.03296961,-0.0057003302,-0.021042382,0.09421348,0.055634983,-0.05634213,0.0064095813,0.031345516,-0.044094585,0.030686596,0.07365011,-0.021781236,0.014477785,-0.016516725,0.03298556,-0.018085845,0.0066370782,-0.04880619,-0.014896417,-0.11579553,-0.06650187,-0.020913089,0.042996265,0.017186455,-0.058952138,0.049386494,0.053995233,-0.013243222,0.04813608,0.0037674257,0.0077676354,0.037965525,0.036773782,0.067254454,-0.00078832667,-0.008379481,-0.05130977,-0.013603595,0.030443026,-0.023494096,0.06773227,0.0512685,-0.041206006,-0.0013101157,0.013912204,0.04941271,0.013604226,0.082447186,-0.0022642156,-0.002443362,-0.030236967,0.06452374,-0.025454711,-0.08729476,-0.0638007,0.008236349,-0.027697273,0.06479635,0.036499057,0.048284214,-0.017364318,-0.013505786,0.021266008,0.098000355,-0.007436246,0.08024719,0.039147355,-0.02474326,-0.082231686,-0.007819314,0.06889493,-0.0010695297,0.13366549,0.042992614,0.017292414,0.00448452,-0.17261435,3.742915e-33,0.09967044,0.0090860035,0.041161146,0.02494958,0.04455341,-0.0010050429,-0.06774196,0.070457734,0.019812336,0.029636774,-0.054492198,-0.007808132,0.12884592,0.0039635464,-0.020707773,-0.118605755,-0.019116616,-0.03344305,0.07752633,-0.012809405,0.025423614,0.103339314,-0.061220746,0.039089195,-0.03618125,0.05359199,-0.0146860555,0.038616277,0.031859223,0.034645397,0.011922422,-0.11981548,-0.07979864,-0.04908133,0.04242813,-0.06377893,-0.11302786,-0.01748954,-0.08612,0.022349235,0.026911682,-0.02241465,-0.013930776,-0.09687148,0.07077946,-0.10800612,-0.03254557,0.09337722,-0.0010305732,0.048550993,-0.009490828,-0.03286751,0.028292775,-0.058808878,-0.033226516,0.013191012,-0.049259067,0.016555201,0.11873452,0.042589363,0.020025201,0.0049809646,-0.053738844,-0.015886227,-0.030276492,0.0032935252,-0.045626212,-0.049189698,-0.039658476,0.06271008,0.0425048,0.01654898,0.062421925,0.012706252,0.06885034,-0.07648808,-0.003050389,0.07504273,0.070086,-0.055680286,0.04510041,-0.018327842,-0.0031865167,-0.05367152,-0.004291197,-0.03935054,0.009771527,-0.0054307794,-0.05604804,0.0916381,-0.0043853913,-0.015499921,-0.106019564,-0.04844989,0.075845495,-4.0033143e-33,0.10114143,-0.083993606,-0.0055076745,-0.11499606,-0.01646963,0.023212897,0.07155689,-0.012461042,0.0229268,-0.04343601,0.108418606,0.008720074,-0.028393766,-0.056897655,0.056828566,0.05768169,-0.003564169,0.019100277,0.039834894,0.0052858326,0.06334153,0.0592826,0.0098098945,0.004512083,0.08187493,0.0063488972,0.0012869263,0.030528283,0.063827425,0.06965897,-0.056396596,0.008212436,-0.008072212,-0.023275113,-0.08700921,0.01890744,-0.07103916,-0.053649608,0.01523902,0.03298805,-0.05057809,0.022808056,0.018105023,0.07319019,0.0485653,0.015271187,-0.09159632,0.018999796,0.0139085855,-0.04976524,0.024235185,-0.024731874,-0.06825226,0.019059103,0.055432286,0.060618274,-0.006820984,0.049666543,0.03709409,-0.0051393653,-0.0076570665,-0.083474405,0.02531044,0.002266658,0.07776101,0.052507073,-0.024207667,0.037691984,0.043046314,0.053713262,0.10086823,-0.05895401,0.0038948888,-0.025110375,-0.0075887656,-0.037767,-0.054097608,0.01508719,-0.044447135,-0.028359111,-0.018020656,-0.025407659,0.033410247,-0.05833339,-0.01122268,-0.05356727,0.031146076,0.09662196,-0.024387088,0.054171246,-0.056517836,-0.031411357,-0.03921206,0.08997168,0.062364366,-4.4972943e-08,-0.054095738,-0.093691446,0.0387144,-0.021189757,0.034673642,0.03444232,0.0036056417,0.059404634,0.024305614,-0.03469173,0.040479425,0.09576059,-0.007843171,0.020651055,0.09000298,-0.052447062,-0.010386699,0.045501307,-0.039259356,0.029791806,-0.012694422,-0.02259286,-0.08640324,0.034421675,-0.015676918,-0.020582398,-0.0024392894,-0.03487212,-0.007817822,-0.057647713,-0.018968325,0.060348347,0.05714788,-0.118516475,-0.10295851,-0.006846758,0.004195141,-0.049683716,-0.06930225,0.021221716,0.01191949,-0.093534485,-0.006039211,0.022947047,0.043760393,0.0060865213,0.001675789,0.031700205,-0.028019002,-0.048630185,0.03575611,0.006322859,-0.019546876,-0.024810158,-0.09014698,0.03534452,-0.02468914,-0.04404686,0.033409357,-0.016217502,0.0028033352,0.05294224,0.18906441,-0.03124707 +1.2.7.3,"The enzyme contains thiamine diphosphate and two [4Fe-4S] clusters. Highly specific for 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).",384,1.0,-0.018758532,-0.007549188,-0.07879297,-0.013973096,0.095500484,-0.02718564,-0.07642287,0.003985033,-0.021065623,-0.039365523,-0.019148117,-0.07778923,-0.031278133,0.03309033,-0.06779917,0.009199148,-0.04991586,-0.044025045,0.038891636,-0.03353749,0.066049114,0.05553904,0.013312145,-0.03942322,0.006110894,0.02970617,0.057113566,-0.045149516,-0.047393713,-0.08274676,-0.06458626,-0.033191197,0.037057806,-0.03562993,0.0105866045,0.086225614,0.0031874848,-0.024926063,0.021382296,0.047628127,0.011094213,0.010727438,-0.025091918,-0.054709367,-0.0400547,-0.07708172,0.02889609,-0.0127280345,-0.023106799,0.053671114,-0.0359014,-0.0383999,-0.036818013,0.0704244,0.04677279,-0.0732565,0.006131362,0.020354666,-0.06841302,0.01324739,0.075483195,-0.033080056,-0.012772104,-0.018537821,0.05123516,-0.037917607,0.049138308,-0.06150218,-0.02289026,-0.13462126,-0.086852714,-0.021621488,0.08353353,0.0052992837,-0.046234228,0.032592084,0.055875525,-0.026524397,0.06069223,-0.014576276,0.019336652,0.024772046,0.03473055,0.066564,0.022317896,0.006629246,-0.024221031,-0.02939451,0.015711257,0.014365604,0.038947806,0.021237174,-0.02394565,-0.013198408,0.0040642982,0.0691394,0.008638341,0.06374965,0.04607838,-0.02172927,-0.013180097,0.0879159,-0.010624909,-0.06808583,-0.061142504,-0.005157641,-0.05293953,0.07351056,0.05289486,0.022652833,0.024846664,0.017818032,0.023371104,0.060281217,0.0047580046,0.082891464,0.024926843,-0.034483206,-0.055331707,-0.0027233579,0.038082007,0.0102343215,0.10406057,0.04805966,0.009843682,0.009512646,-0.17914195,2.6505792e-33,0.09920984,0.015678702,0.00846957,0.022674304,0.023401361,0.003458274,-0.085567124,0.056379545,-0.036323663,0.044569716,-0.08775624,-0.038635865,0.12161288,-0.024663404,-0.024524312,-0.11552421,-0.03522175,-0.030661127,0.08449852,-0.020313727,0.022979064,0.11658381,-0.043970797,0.034063365,-0.033457313,0.065872386,-0.01542037,0.033828594,0.028943738,0.020515906,0.047729038,-0.114875965,-0.09704382,-0.058076825,0.041274734,-0.07170665,-0.098845765,-0.014612581,-0.06645813,0.016323628,0.008651694,-0.0014061177,0.009837293,-0.07959132,0.06933063,-0.10174876,-0.036899254,0.097947076,0.004212899,0.06494503,-0.005879265,-0.019161033,0.06744152,-0.05877699,-0.06653216,0.01636137,-0.030675894,0.009148345,0.11005553,0.05407347,0.0327141,0.033684943,-0.034051143,0.010650896,-0.03104662,0.00037569526,-0.02149632,-0.027130296,-0.015218324,0.090208836,0.027020289,0.0015946414,0.08749435,-0.001632116,0.053626984,-0.0796543,-0.0064782887,0.081906535,0.04319884,-0.039237663,0.022116901,0.00256017,0.0011234656,-0.04555882,-0.04257156,-0.03490165,0.00751819,-0.0072509926,-0.05146806,0.08750329,-0.0014246304,-0.0065973992,-0.07199428,-0.04773989,0.06229915,-3.116693e-33,0.11021746,-0.09264174,0.009546378,-0.1336247,-0.044190258,0.012471572,0.061634734,-0.004256963,0.001984029,-0.00012018663,0.114214525,0.013949834,-0.0036598272,-0.06577416,0.04434778,0.069742866,-0.043986782,0.020554071,0.053466775,0.015179061,0.0487226,0.068548664,0.003358861,0.013024393,0.083478995,0.0013362442,-0.0195075,0.023418292,0.05110877,0.056304943,-0.068649866,-0.018924609,-0.007132904,0.0003439787,-0.08558513,0.019824648,-0.056671802,-0.0424966,0.014727671,0.057555217,-0.043259747,0.034645554,0.017378118,0.08787405,0.043861132,0.024688147,-0.07201717,0.023060413,-0.011247002,-0.03269086,0.014282071,-0.018446533,-0.05040163,0.008405911,0.048628237,0.053665128,-0.023621641,0.04229015,0.0035673077,-0.003308897,0.011419774,-0.11109728,0.047658652,0.03927621,0.06681063,0.04429649,-0.028580582,0.00042285767,0.031105058,0.07353069,0.06947965,-0.0474513,0.021254268,-0.04035476,-0.016922481,-0.06844113,-0.038404178,0.018217977,-0.046304394,-0.022911241,-0.001534543,-0.015008012,0.031000033,-0.036863185,-0.015918434,-0.07408068,0.048109148,0.12038877,0.0068295994,0.020395752,-0.0433993,-0.019016877,-0.020717902,0.041510217,0.051092967,-4.3438476e-08,-0.041620605,-0.10571577,0.045872748,-0.017087704,0.036598567,0.014838566,-0.013678078,0.047068197,0.023235912,-0.0063750446,0.036873747,0.11154489,-0.005400715,-0.006143221,0.08596926,-0.044084035,-0.035543703,0.05753261,-0.037428476,0.014289388,-0.032296754,-0.02538329,-0.09444511,0.038430844,0.01604722,-0.025749482,0.0010348416,-0.039627314,-0.014285517,-0.06702893,-0.02474451,0.04416105,0.019580657,-0.12865761,-0.104644515,0.0111232605,-0.0136968335,-0.04446244,-0.07138265,0.03126109,0.015210871,-0.096825264,-0.014198085,0.033039756,0.032812122,0.025756063,-0.0017310501,0.018267883,0.0007993922,-0.016479697,0.015674325,0.0057842704,-0.004815552,-0.02087008,-0.09610319,0.028368501,-0.025631659,-0.04470085,0.03819297,-0.023424055,0.03783142,0.08100705,0.19058584,-0.0617676 +1.2.7.4,"This prokaryotic enzyme catalyses the reversible reduction of CO2 to CO. The electrons are transferred to redox proteins such as ferredoxin. In purple sulfur bacteria and methanogenic archaea it catalyses the oxidation of CO to CO2, which is incorporated by the Calvin-Benson-Basham cycle or released, respectively. In acetogenic and sulfate-reducing microbes it catalyses the reduction of CO2 to CO, which is incorporated into acetyl CoA by EC 2.3.1.169, CO-methylating acetyl-CoA synthase, with which the enzyme forms a tight complex in those organisms. The enzyme contains five metal clusters per homodimeric enzyme: two nickel-iron-sulfur clusters called the C-Clusters, one [4Fe-4S] D-cluster; and two [4Fe-4S] B-clusters. In methanogenic archaea additional [4Fe-4S] clusters exist, presumably as part of the electron transfer chain. In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S protein EC 1.12.7.2, ferredoxin hydrogenase, which catalyse the overall reaction: CO + H2O = CO2 + H2. cf. EC 1.2.5.3, aerobic carbon monoxide dehydrogenase.",384,1.0000001,-0.07520475,-0.027523516,-0.11877727,0.017241802,0.1346767,0.05099684,-0.07785633,-0.032362208,0.034031376,-0.05250403,-0.026457243,-0.061889425,-0.03532945,-0.038595185,-0.048354674,0.014234824,-0.054666303,-0.018204039,0.0058417516,-0.03914042,0.010550151,-0.022109266,-0.03798287,-0.041296136,-0.04610569,0.09288131,0.02507183,-0.06762251,-0.05561121,-0.0618399,0.010000472,-0.061112065,0.06444091,-0.04558235,0.0057351477,0.08441601,0.035605278,-0.03453619,0.04356579,0.0025507465,-0.023644218,0.04437014,0.023381501,-0.048716247,-0.034956302,-0.046176065,0.035099614,-0.016007766,0.0020869342,-0.13364847,-0.030526288,-0.035561662,-0.085775346,0.065703966,0.030445974,0.036055595,-0.036348928,-0.09102374,0.06311789,-0.06574188,0.07806277,-0.03787359,-0.005239063,-0.014728505,-0.00886888,-0.024541453,0.07006657,-0.08079272,0.019901225,-0.039535247,-0.05354446,0.027034927,-0.057142418,0.017072268,0.000108327185,0.04093024,0.051702257,-0.06082603,0.07457966,0.0034472558,-0.028748928,0.07734784,0.044400815,0.03704644,0.02313711,-0.016677411,-0.0004483292,-0.03729301,0.0235333,-0.0038155366,0.021847282,0.028228728,0.011411425,-0.02739993,-0.08984732,-0.001456538,0.08894577,0.056658894,0.096385404,0.0044373004,0.014043726,0.100208424,-0.05895121,-0.1367396,-0.03989008,-0.007898837,0.027357357,0.22503352,0.08609697,0.08171106,0.02400403,-0.0030553397,0.021485884,0.0107738385,-0.026899232,0.1381045,0.06571831,-0.042803723,-0.06587549,0.07512175,0.052256882,0.039489415,0.06273705,0.04189061,0.011983591,0.010760141,-0.17159931,2.4534591e-33,0.099364705,0.052740928,0.029533185,-0.029948086,0.03596664,-0.049591456,-0.12572868,0.03092182,0.06068562,0.0010566604,-0.067943946,0.0009051312,0.057510976,-0.044962745,-0.03922705,-0.04984327,-0.03267978,-0.011352209,0.007901335,0.02681813,-0.03953727,0.056711856,-0.00958553,0.032833282,0.029370336,0.036768544,0.0051711146,0.0072665093,0.028777385,0.01247991,0.017425466,-0.07224084,-0.09446495,0.008781635,0.09364266,-0.02506051,-0.026571706,-0.00398861,-0.01674552,0.017916005,0.0043350407,0.042339087,-0.07225505,-0.031976968,0.07302945,-0.06397971,-0.008400707,0.054254036,0.0074811047,0.04231043,-0.008250481,-0.015015931,0.100754306,-0.00079286296,-0.08061256,0.018257858,0.011169402,-0.01262455,0.08857067,0.053530086,0.00031473226,0.062390573,0.033558417,0.056150816,-0.0039312225,0.030043896,-0.0012413212,0.0037687188,0.05712137,0.075073406,-0.052872464,0.027361512,0.08788344,0.04793603,0.016181195,-0.06659463,0.0026501257,-0.055627823,0.05009948,0.011764112,-0.013001349,0.0009299152,0.020284493,-0.08542847,-0.012073898,-0.032461964,-0.044093534,-0.052914478,-0.0348651,-0.004405968,0.014632643,-0.053815767,-7.2838346e-05,-0.051566184,-0.051041342,-3.0114051e-33,0.09681449,-0.09518697,-0.0023135897,-0.12717602,-0.11425295,0.049525533,0.024915455,-0.016896855,0.026712524,-0.01068327,0.09301406,0.015177787,0.053827498,-0.0038365568,0.025539814,-0.008014624,-0.0016053546,0.049574263,0.0016630205,0.011442073,0.038400687,0.030240722,-0.00072750624,-0.0064519793,0.06232813,0.011796359,-0.038541943,0.023790589,0.11784829,0.045314237,0.028122533,-0.02260231,-0.04405393,-0.029235711,-0.07354406,0.00946972,-0.04314329,0.038548503,0.01689672,-0.009774442,0.02798228,-0.053007208,-0.035227127,0.0750936,0.036768556,0.011056439,-0.08244027,0.02618717,0.004716919,-0.021674318,0.012704322,-0.02608718,-0.08307639,-0.009040797,0.013965873,0.042083587,0.022236133,0.044369936,-0.013098889,0.023943376,-0.06301082,-0.09923353,0.039356314,0.0022228316,0.059069566,0.028460069,0.0009900845,0.021853503,0.032909695,0.021055931,-0.020701515,0.03090428,0.06703635,-0.0027598636,0.015336506,-0.05196443,0.012777236,-0.022583848,-0.03752123,-0.01260193,-0.03246785,-0.0056401305,0.043325793,-0.08426318,-0.03330536,-0.090409584,0.034564734,0.10323817,-0.034785762,0.04793541,-0.05091344,0.008844607,0.027026584,0.013632147,-0.024544448,-4.2573394e-08,0.015419969,-0.012472523,0.08502215,0.030558309,0.016932273,0.07994975,-0.006550499,-0.037297018,0.020058393,-0.034457054,-0.001097119,0.10441296,0.018165667,-0.049832527,-0.020149052,0.02022942,-0.062136855,-0.01912438,-0.015437535,-0.0048528044,-0.040683467,-0.039079882,-0.08023318,0.089951396,0.028582923,-0.10758543,0.035885647,0.025746066,-0.09496188,-0.09895197,-0.05065958,0.039640754,0.015909428,0.007606696,-0.041259166,-0.041679867,-0.031511046,-0.009890212,0.015743084,6.4548185e-05,0.0068258466,0.04219597,-0.10061726,0.019486297,0.022495707,0.033969067,-0.023076667,0.05892465,-0.006419697,0.031462524,0.022193464,-0.008547773,0.02312178,-0.054625675,-0.07686019,0.0648725,-0.008157565,-0.035271667,0.0013506928,0.029052043,0.038038645,-0.042155117,0.083925866,-0.049045216 +1.2.7.5,"This is an oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters. Catalyses the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. However, it does not oxidize glyceraldehyde 3-phosphate [see EC 1.2.7.6, glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)]. Can use ferredoxin or methyl viologen but not NAD(P)+ as electron acceptor.",384,0.99999994,-0.015298917,-0.02634215,-0.0935345,0.068845056,0.10968864,0.024864502,-0.048452057,-0.048577916,0.0051182243,-0.03856562,-0.017742869,0.016105574,-0.07603203,0.0013893332,-0.08237819,0.051679738,-0.00883829,-0.051583007,0.013156566,0.009985043,-0.016310545,0.018030457,0.044876523,-0.040116813,0.059908614,0.07929292,-0.004010817,-0.0045793387,0.010841809,-0.027687011,-0.0003434418,-0.036756143,0.02396999,-0.0023037544,0.00813677,0.08323446,-0.0671901,0.01706392,-0.01396827,0.015502303,-0.030560069,-0.0065891533,-0.031154282,-0.040782947,-0.044910766,-0.07046863,-0.0004371696,-0.029166004,-0.025533497,0.07873983,-0.01849715,-0.057527542,-0.012207741,0.030295854,0.045134082,-0.052015085,-0.0007594486,0.0075113378,0.009700689,-0.030817464,0.015084764,-0.04294147,0.051625457,0.021673746,-0.004745771,-0.06886269,0.06617421,-0.052995052,-0.017483745,-0.1299289,-0.07831999,-0.011341708,-0.012355162,-0.0015107254,-0.043771528,0.081099786,-0.02947568,-0.049778216,0.119805776,0.042308275,0.021741064,0.026435578,0.030374419,0.14006434,0.093928345,0.008198591,-0.041535277,-0.0072736335,-0.04019924,-0.025223989,-0.031637985,-0.00073599844,-0.026453879,0.0022467372,-0.06459178,0.01506475,0.061201315,0.0365073,-0.029565768,-0.004883786,-0.065604314,0.1136705,-0.040934127,-0.09989649,-0.08444996,0.027798666,-0.08036251,0.121004,0.052145064,-0.02073509,-0.033995453,0.02820202,0.03559384,-0.045616023,-0.004856991,0.08798471,0.014647582,-0.03346838,-0.06269926,0.013069153,0.025286814,-0.010970672,0.03746404,0.017773284,-0.033479765,-0.028649516,-0.0374524,4.8136795e-33,0.10350128,0.048527706,-0.025928197,-0.028476126,-0.0036985045,0.0015501311,-0.074130304,0.030283064,-0.061417527,-0.0027601724,-0.03286168,-0.0630307,0.09786592,-0.012632661,0.05224385,0.018918434,-0.031047683,-0.07272925,0.051646728,-0.029020494,0.102107294,0.05367018,-0.02862576,0.01554831,-0.04125348,0.062754646,-0.027402617,0.021101668,0.02648332,-0.0110342,0.07528133,-0.044997692,-0.10734075,-0.031062385,-0.02110644,-0.025630904,-0.09362154,-0.06509957,-0.01497866,0.024238149,-0.017412044,0.010305784,0.0027875055,-0.06688134,0.0798474,-0.048040833,-0.016398435,0.05878366,0.042662457,0.089888416,0.049633246,-0.029266564,0.08695028,-0.003224311,-0.09814539,0.06674009,0.02932749,-0.036204983,0.04930018,0.06251422,0.016616805,-0.036977038,0.008152666,0.014189796,-0.020469168,-0.03155754,-0.009714022,0.0056078816,-0.012828513,0.058294643,-0.013868483,0.056523953,0.05936812,-0.0047651604,-0.013005507,-0.04340953,-0.0063153924,-0.019020494,0.03914135,-0.053757206,0.003903098,-0.02687933,0.05128207,-0.052025776,-0.014315688,-0.010602537,-0.078975275,-0.053178485,-0.026964188,0.031274576,0.023549067,-0.06909119,-0.06276964,-0.0781029,-0.039177828,-5.4092444e-33,0.12684928,-0.048447944,0.021339865,-0.103356995,-0.04208557,0.05588312,0.009733734,-0.0020270643,-0.000743985,-0.034004,0.037766527,0.014040081,0.07922067,-0.042040054,0.054845296,0.038709752,-0.012932733,0.029047571,0.026591707,-0.026273204,0.09080747,0.0538239,-0.0005872158,-0.016177362,0.0832225,-0.0010047951,-0.026954848,-0.03747826,0.12672672,0.05986449,-0.0282178,0.032224085,-0.015334126,-0.06013266,0.015629584,0.041737203,-0.090999775,-0.022328733,0.0003265831,0.03988671,0.023040112,0.014758731,-0.022064755,0.11042607,0.038146574,0.08676554,-0.15446907,-0.010250191,0.04626262,-0.055965926,0.014171874,0.05001579,-0.07122835,0.040577088,0.09099174,0.08866022,-0.028229335,-0.04366316,-0.026011512,0.006339493,0.0007098128,-0.040298216,0.03915421,0.007812084,-0.014387968,0.10015996,-0.008926871,0.02466454,0.016157957,0.014600918,0.059353396,0.0018940222,0.027992684,0.04340367,0.032072335,-0.07616375,-0.010533042,0.076085106,-0.03049314,0.014495531,0.07284486,0.011188977,0.033347275,-0.05755801,0.034130517,-0.072823815,-0.022612523,0.12815368,-0.023166109,0.001533081,-0.03746281,0.039182324,0.023257876,-0.025398087,0.025738679,-4.6586134e-08,-0.034953356,-0.066303365,0.10261261,-0.07083432,-0.013469159,0.026709111,0.09971555,-0.02574262,-0.05961515,-0.047305983,0.027085716,0.07860115,-0.0028827705,-0.06892051,0.012663446,0.018081099,-0.044123083,0.023821827,-0.04462554,-0.0018009351,-0.0849099,0.0047687828,-0.03849204,0.08032372,0.004596108,-0.022230873,0.0009012827,-0.030388592,0.0063549103,-0.04158772,-0.041936092,0.0706175,0.03336491,-0.036065888,-0.14039913,0.029883834,-0.024058929,-0.009114664,-0.069286525,-0.016551105,-0.007178146,-0.071139544,-0.022204325,-0.00074406335,0.021151742,0.041655842,-0.0004984434,-0.024683323,-0.024850708,-0.0017817478,0.075467885,-0.00071486156,-0.0074568377,-0.006852725,-0.1348115,0.08679265,-0.006460748,-0.075417005,0.0071732625,-0.09624773,0.007307249,-0.031839095,0.18131292,-0.032615583 +1.2.7.6,Contains tungsten-molybdopterin and iron-sulfur clusters. This enzyme is thought to function in place of glyceralde-3-phosphate dehydrogenase and possibly phosphoglycerate kinase in the novel Embden-Meyerhof-type glycolytic pathway found in Pyrococcus furiosus [1]. It is specific for glyceraldehyde-3-phosphate.,384,1.0,-0.021147184,-0.04872789,-0.14906698,0.011843306,0.068382986,0.016330294,-0.08423968,0.004800154,0.021052072,-0.010792607,0.013551976,-0.0104864435,-0.097477674,0.011998209,-0.10459754,0.0018976866,-0.059444703,-0.0024887868,0.03038062,0.019026022,0.026801405,0.0029588225,0.040180933,-0.060235538,0.012757781,0.0044007916,-0.02329664,0.022942858,-0.029900743,0.013590169,-0.036321744,-0.09562322,0.015222584,-0.033820312,0.055922437,0.07905546,-0.019819967,0.033929262,0.044850107,-0.009114338,0.02741217,-0.022962898,-0.02910535,-0.0032636914,-0.038529806,-0.007824807,0.05330704,0.029085433,0.005461736,0.0057218024,-0.035542298,-0.04948985,-0.058548838,0.041572355,0.009776574,-0.04082683,-0.059197336,0.028538076,0.046999753,-0.04319209,0.026648516,-0.04956617,0.08441337,0.02042366,0.014530967,-0.05490956,0.057143293,-0.010265649,-0.018838178,-0.03767893,-0.074599996,-0.00089523266,0.0015307235,0.009785896,-0.017083237,0.19231533,-0.054159477,0.0021604917,0.046932943,-0.024828723,0.04138531,0.039324176,0.039125077,0.08560414,-0.0040956535,-0.05583994,-0.007350958,-0.063103974,-0.0029049413,0.015455906,0.016930366,-0.045363035,-0.041371003,-0.02050572,-0.095440425,-0.02284042,0.060414523,0.08949141,-0.012798486,-0.04790606,-0.102620356,0.027725749,0.030368589,-0.052824624,-0.06931712,0.002870983,-0.069146074,0.082169384,0.07949378,-0.0039551295,-0.0632928,0.111353256,-0.053991385,-0.02740296,0.048210453,0.026098043,0.06715589,-0.0820199,-0.081891514,0.07638784,0.010939296,0.006129391,0.011404113,0.027740706,-0.06313955,-0.012060844,-0.012632369,3.983871e-33,0.069310874,0.04118035,0.0677534,-0.02155172,0.07593921,-0.06633227,-0.07657516,-0.05690317,-0.09606562,0.020640252,-0.031083114,-0.046337295,0.087407954,-0.0031495949,-0.05731523,0.035008013,0.0010828449,-0.046610452,0.06340797,-0.019841984,0.105429694,0.045823324,-0.0005472168,-0.05250513,0.04425847,0.097573556,0.030970767,0.010355928,-0.005645243,-0.005048303,0.03706564,-0.13075203,-0.13161898,-0.033939645,0.063076355,-0.07211171,-0.029159168,-0.078988574,0.040113866,-0.028175177,-0.03287327,-0.020820562,-0.008156407,-0.019667674,0.061383024,0.003873877,-0.021678388,0.0481941,0.02126783,0.06850688,0.026704501,-0.05160621,0.092726655,0.02307991,-0.04106694,-0.01922377,0.006427404,-0.041646503,0.013081295,0.055699393,0.042907298,0.032966737,-0.022311207,-0.015714314,0.02394874,-0.032060042,-0.08320694,0.004143406,0.015345133,0.0831301,-0.045719095,0.018707732,0.059595093,-0.02073074,-0.054060966,-0.04565362,0.00876231,0.01615159,-0.042284925,-0.009383625,-0.0034595379,6.795773e-05,0.037885427,-0.02776528,-0.06577922,0.025614358,-0.10394633,-0.07262128,-0.038520552,0.06634521,0.007022154,0.051454168,-0.07047319,0.018029468,-0.07748816,-4.9520256e-33,0.14118187,-0.057922203,0.112183884,-0.058310896,-0.09717723,0.11679405,-0.014585485,0.028666595,-0.0053346995,0.004567741,0.053611185,0.006210562,0.04909467,-0.034696274,0.019401357,0.038590923,-0.012011372,0.052358467,0.062315404,-0.016111605,0.06015863,0.035354137,-0.04961755,-0.03919203,-0.0056342124,0.025385413,0.026868666,0.042180937,-0.028051663,0.011598963,0.018434495,0.017268006,-0.042165995,-0.07520255,-0.052295864,-0.022105517,-0.06380911,0.0037302386,0.021631137,-0.05036529,0.03920211,0.010447892,-0.0031830468,0.072808646,0.023597704,0.07537067,-0.062089637,0.036476023,0.05782499,0.005976392,0.036546618,0.022688242,-0.047899406,0.06343131,0.052007142,0.085002564,0.0069141807,-0.033687033,-0.04580911,0.026783066,-0.01776695,-0.09366196,0.042922944,0.05160895,0.053996876,0.07273701,-0.0060390085,0.0260381,0.055517584,0.04090558,0.03910612,0.049979147,-0.019040938,-0.013945653,-0.020818273,0.062246952,0.024774762,0.001571553,-0.0032647992,0.03628569,0.03962045,0.035506357,0.007991359,-0.065025285,0.066568024,-0.052692596,0.030981457,0.12195405,-0.02357028,-0.03297092,-0.039579205,-0.046241853,-0.02763971,-0.0116389245,0.0312295,-3.8480117e-08,-0.015053269,-0.046139777,0.009578376,-0.03833991,-0.004141531,0.015621651,0.017582387,-0.008719379,-0.054665316,-0.037561025,0.077223465,0.0355708,0.040792506,-0.07581992,0.060002923,0.03145799,-0.05112724,-0.008674844,-0.008269508,0.030078124,-0.04869181,-0.027108528,-0.08860055,0.09407626,0.052803878,-0.032708995,0.040929906,0.016796945,-0.040629208,-0.015950225,-0.010060645,-0.0026297194,-0.000566263,0.045925636,-0.043500215,-0.039688844,-0.14616264,0.010447961,-0.06029875,-0.026915152,-0.0021433507,0.014744034,0.008369765,0.014008931,-0.050843965,0.080540866,-0.056322977,0.05426155,-0.05342786,-0.004658675,0.06897866,0.023130832,-0.0001288453,-0.040299006,-0.17149913,0.07733588,0.017416155,-0.08847163,-0.049235493,-0.03750511,0.03328464,-0.103274904,0.101705074,0.006369212 +1.2.7.7,"The enzyme is CoA-dependent and contains thiamine diphosphate and iron-sulfur clusters. Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo-pentanoate, and 2-oxobutanoate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that reversibly catalyse the oxidative decarboxylation of different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase, and EC 1.2.7.3, 2-oxoglutarate synthase.",384,1.0,-0.030931521,-0.043992978,-0.08903151,-0.0113746915,0.11431508,-0.0040132287,-0.11047023,0.037861492,0.036824133,-0.029656556,0.009606962,-0.058241714,-0.041021626,0.032070763,-0.016280394,0.013865458,-0.042452987,-0.013126042,0.037199706,-0.04576581,0.069406725,0.029729558,-0.020364027,-0.010189196,0.009975404,0.04385209,0.097853206,-0.035798978,-0.04279657,-0.06768273,-0.057124257,-0.080282696,0.019465169,-0.04306,-0.005712187,0.086254984,-0.013617241,-0.059412524,-0.032230426,0.020527648,0.045089718,0.02303029,-0.044155896,-0.066671275,-0.031171221,-0.094187096,0.047025695,0.00062771887,-0.05937309,0.030135414,-0.01768926,-0.063183,-0.07424199,0.06218359,0.044630688,-0.04431226,0.004083442,0.0069520264,-0.0377117,-0.021596575,0.026291784,-0.0044618957,0.005374438,-0.04799097,0.01733376,-0.02680132,0.065746434,-0.060164105,-0.0076097604,-0.12201562,-0.087931305,-0.018507777,0.04347027,0.022820566,-0.026620217,0.047571663,0.049817644,0.00046158434,0.03936537,-0.0037749815,-0.016789354,0.032567207,-0.022092741,0.061379444,0.015038633,0.0005100104,-0.0049724355,-0.011476573,0.060420305,0.011608288,0.038747583,0.0057096356,-0.013177699,-0.032609526,0.00078819465,0.038938817,0.01395623,0.115273714,0.037760876,-0.015316123,0.00066879153,0.107299596,-0.019503433,-0.08989284,-0.033706866,0.0025758261,-0.04172972,0.079537705,0.04772157,0.045591664,-0.016973918,-0.019202994,0.013742362,0.007935152,-0.0004148115,0.0983175,0.021155613,-0.024517521,-0.06907492,0.051457603,0.06343152,0.030548645,0.105589926,0.06774222,0.024024274,0.0037289949,-0.14847562,2.4745074e-33,0.074196905,0.02540682,0.024537092,0.013794749,0.032074183,-0.030714907,-0.10230589,0.074166656,-0.009312923,0.03335898,-0.045335874,-0.003263235,0.09137729,0.0117542045,0.013961375,-0.10005589,-0.012924541,-0.0027206973,0.06619924,0.012641347,-0.0072914334,0.08179395,0.002863457,0.045894235,-0.046142213,0.027640551,-0.013216037,0.069516815,0.019065855,0.018142294,0.02444284,-0.12945266,-0.10083351,-0.076694205,0.039095826,-0.07571529,-0.097384766,-0.016021322,-0.05830125,0.036100492,0.03672477,-0.019081196,-0.01895432,-0.039414354,0.06710515,-0.11294058,-0.029192094,0.100719586,0.024122233,0.024988206,-0.016116468,-0.026675664,0.07075639,-0.03806707,-0.06574363,-0.007084698,-0.062356997,-0.0016746073,0.08028138,0.02573788,0.033438236,0.055501778,-0.03463207,0.015082984,-0.060820773,0.0053743925,-0.058215946,-0.029347885,-0.011457485,0.06895513,0.004444016,-0.0121565135,0.023847893,0.031217577,0.048609104,-0.11616072,-0.035714615,0.061014283,0.067147635,-0.05130269,0.003108562,0.0062878476,0.006258202,-0.015083568,-0.06329196,-0.03133259,0.005423456,0.003816754,-0.05161088,0.0579658,-0.006592113,-0.016290613,-0.033448476,-0.038683306,0.082819566,-3.2778564e-33,0.08040061,-0.09938454,-0.021272885,-0.15462653,-0.054511555,-0.0056808274,0.027861748,-0.01106986,0.0053061047,-0.07814895,0.043034904,0.0065861284,0.0001440703,-0.049207237,0.033759624,0.056477822,-0.0003870627,0.059962872,0.040776916,-0.012165652,0.04366001,0.02870912,-0.0048715402,-0.016084086,0.08263455,0.023716467,-0.023146462,0.04907852,0.06693644,0.08871781,-0.060799614,0.030412843,0.0056852954,-0.011230816,-0.09541723,0.053068172,-0.050947364,-0.03154663,0.038246803,0.07331232,-0.048038084,0.020751037,0.042188857,0.054351475,0.056325857,0.021817232,-0.0715701,0.005033178,-0.025526889,-0.052754592,0.026641449,0.01894661,-0.053240746,0.038866565,0.039535873,0.04739905,-0.040720258,0.048688345,0.033934683,-0.04748451,-0.01959761,-0.080997765,0.022867123,0.005328548,0.04366765,0.04212828,-0.02634039,-0.014115659,0.031979356,0.07278663,0.044099554,-0.0152233485,0.013781819,-0.0746079,-0.013139691,-0.06024463,-0.051679637,0.04412465,-0.053435966,-0.04569131,-4.8049584e-05,-0.044025123,0.033826157,-0.03681604,-0.042798378,-0.060790405,0.034542706,0.11199999,-0.009816146,0.05166949,-0.028597679,-0.0594902,-0.04235722,0.10206838,0.05111202,-5.076857e-08,-0.05230258,-0.11061378,0.050643105,0.0230001,0.03802513,0.03833581,-0.009299426,0.0031110577,0.03549524,-0.010073999,0.029186632,0.11734123,0.01456698,-0.002985932,0.06966346,0.012458099,-0.015697094,0.10346745,-0.016478907,0.03729573,-0.04708106,-0.020194992,-0.081054,0.025945133,0.025547344,-0.040355094,0.0142975785,-0.026857918,-0.03936858,-0.04193561,0.013803237,0.053198267,0.035487793,-0.100387104,-0.040863,0.008656312,0.0021842485,-0.025059583,-0.06372607,0.054079615,0.022397911,-0.051124316,-0.066715635,0.051930986,0.09014578,0.024127409,0.0038230766,0.045969516,-0.047274422,-0.040216677,0.041476745,0.016769916,-0.025833407,-0.05312703,-0.08705509,0.023130702,0.0013808714,-0.077306606,-0.010058575,-0.013020638,0.03851061,0.07017821,0.21041447,-0.064150214 +1.2.7.8,"Contains thiamine diphosphate and [4Fe-4S] clusters. Preferentially utilizes the transaminated forms of aromatic amino acids and can use phenylpyruvate and p-hydroxyphenylpyruvate as substrates. This enzyme, which is found in archaea, is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).",384,0.99999994,-0.031474814,-0.041678425,-0.08497564,-0.02839077,0.10135009,-0.020531697,-0.115369625,0.001581079,0.022899207,-0.038032062,-0.023610428,-0.095924154,-0.018908685,0.015880456,-0.0630233,-0.0018653192,-0.053769298,0.003650554,0.07733687,-0.024358632,0.039039254,0.08953374,-0.002690716,-0.0025989567,-0.021756865,0.04184288,0.08058038,-0.048250742,-0.046414375,-0.07565009,-0.023945857,-0.057373505,0.07118167,-0.03798723,0.009752542,0.11886636,-0.01688277,-0.04270312,0.055025715,-0.012145952,0.035431873,-0.014726579,0.013193266,-0.07111325,-0.052072637,-0.053174462,0.05141589,-0.022912107,-0.014379475,0.020960549,-0.026764294,-0.033632476,-0.05860516,0.08415,0.035341885,-0.0072986954,-0.0029823887,-0.030032743,-0.029190669,-0.0142594585,0.0485513,0.00015205007,0.03866162,-0.03464069,-0.008210242,-0.016028343,0.050343513,-0.06355408,0.024248268,-0.11092437,-0.05033794,-0.020703128,0.058402244,0.036818054,-0.073564984,0.08031686,0.04224398,-0.026008043,0.025904546,-0.04216982,-0.01631003,0.0018110784,0.014650373,0.063466996,0.03362723,-0.03263213,-0.025714656,-0.025295941,0.018106896,-0.019556945,0.071080096,0.049495574,0.0034973936,-0.05485446,-0.006559958,0.01661564,0.03550675,0.058243494,0.03736349,-0.013238099,-0.022054369,0.08928203,-0.015729656,-0.09773737,-0.08810547,-0.021421358,-0.036130983,0.13332747,0.040659893,0.029390315,-0.0016963792,-0.026637647,0.032595545,0.03735264,0.0050374684,0.058196317,0.02061404,-0.05560633,-0.100266315,0.037744097,0.00814934,-0.0025656202,0.13449427,0.05702236,0.004768061,0.03069589,-0.1667668,3.77724e-33,0.108138464,-0.001729659,-0.00431819,0.0063762423,0.042135425,-0.00056307507,-0.08761197,0.06195206,0.018023238,-0.018603897,-0.055958822,-0.024550382,0.118419684,-0.028489003,-0.0074388497,-0.0919757,-0.04941102,-0.020259734,0.056467377,0.01592257,-0.00822756,0.07570454,0.0013285422,0.019124368,-0.007588517,0.018104276,-0.0038643787,-0.002566171,0.039887544,0.025266308,-0.0066480553,-0.14087324,-0.12262226,-0.06257053,0.057436984,-0.030330954,-0.06334872,-0.016921911,-0.10131718,0.02424513,0.0066115023,-0.018265488,0.014042848,-0.07660373,0.08992219,-0.06999341,-0.005936991,0.14689401,-0.019336432,0.061337084,-0.0072664763,-0.03635745,0.086772725,-0.05676203,-0.07049771,0.004475183,-0.055618975,0.004285437,0.09472256,0.052991826,0.042707857,0.063336305,-0.031670596,0.037405785,-0.027096983,0.012173333,-0.04094217,-0.028168706,-0.01555083,0.0681724,0.052081335,-0.009227909,0.058206156,0.053812303,0.016585443,-0.09835054,-0.062446102,0.032234546,0.053785745,-0.037167512,0.005253462,-0.01749807,0.0036021983,-0.023684524,0.0092172,0.016040295,0.010389298,-0.003085696,-0.045094952,0.064953506,0.02619112,-0.0491529,-0.040265705,-0.03933184,0.02765382,-3.745992e-33,0.085715406,-0.12665439,-0.020727674,-0.11732467,-0.04993633,0.034717757,0.01318279,0.027067808,2.1946093e-05,-0.06200192,0.08730551,0.02742731,-0.0020848864,-0.10647606,0.03969391,-0.008519869,0.010562452,0.025151748,0.062097523,-0.0010743676,0.084941715,0.022616856,-0.017029798,0.0019649968,0.0763274,0.031529184,-0.022608042,0.059079017,0.03669623,0.07922082,-0.058309693,0.057177257,-0.018933846,-0.0049488554,-0.075732924,0.0527014,-0.069716565,-0.05719681,0.0348842,0.015697056,-0.0259166,0.04342549,0.010628508,0.06753605,0.056906946,0.025616005,-0.07550491,0.03089846,0.01817163,-0.029107373,0.020237723,-0.06737727,-0.04001552,-0.023258608,0.02762789,0.04054807,-0.036997087,0.0859636,0.021828054,0.0023020993,-0.013875289,-0.11070878,0.057514504,0.01229436,0.036932006,0.0404913,-0.012525744,0.04335856,0.028419979,0.051911455,0.049292143,-0.041783407,0.026094252,0.022386031,0.027529338,-0.034886666,-0.008292441,0.012072494,-0.019482646,-0.04479401,-0.009090328,-0.035210747,0.03445449,-0.062337782,-0.011934312,-0.05773471,0.044449054,0.084082164,-0.036630392,0.03249516,-0.049460415,-0.041392166,-0.05063042,0.04002573,0.050185744,-4.6281368e-08,0.0036715697,-0.069905035,0.07644198,0.0023129825,0.035638765,0.03875283,0.015863972,0.026265463,0.030987864,-0.07165214,0.044190697,0.075957336,0.0117960265,0.01673566,0.052180037,0.013939408,-0.025309192,0.06490878,-0.054017734,0.00878668,-0.038271856,-0.028565012,-0.06573451,0.043727703,0.027161425,-0.04998649,-0.0029426839,-0.046744574,-0.0034071342,-0.08404494,-0.011140933,0.042592738,0.043298155,-0.085823864,-0.03769807,0.010396038,-0.030734893,-0.04447249,-0.0586559,0.037369277,-0.023824746,-0.044978227,-0.07301757,0.014593228,0.08643768,0.028682511,-0.023555716,0.09051135,-0.06291926,-0.0164406,0.03893162,0.0010970448,0.047125567,-0.04727101,-0.08447768,0.00089164113,0.0028104915,-0.061823506,0.009951207,-0.0062605897,0.03907818,0.066793665,0.1729178,-0.023742847 +1.2.99.2,"Contains a [Ni3Fe-4S] cluster and [4Fe-4S] clusters. It uses many electron acceptors, including ferredoxin, methyl viologen and benzyl viologen and flavins, but not pyridine nucleotides. Forms part of a membrane-bound multienzyme complex with EC 1.12.99.6, hydrogenase (acceptor), which catalyses the overall reaction: CO + H2O = CO2 + H2.",384,0.99999994,-0.028860668,-0.008020418,-0.12465584,0.0072315214,0.09693743,-0.0032695993,0.013765522,-0.027007304,0.021177467,-0.08720966,-0.00529781,-0.08791078,-0.113712005,0.022402221,-0.022512771,-0.040583216,-0.073795974,-0.021127686,0.055035464,-0.06478554,-0.046726137,-0.016371567,0.05688255,-0.094996095,-0.103086695,0.116394244,0.07125864,-0.052956127,0.039380126,-0.09596672,-0.02765083,-0.011095728,0.08626334,-0.058431245,0.01606647,0.0723894,-0.010478463,-0.029124202,-0.0063867485,0.0023637773,0.010505221,-0.02029234,0.07093305,0.0071202163,-0.0036804844,-0.025657902,0.014940255,0.0059005106,0.02962641,-0.07924687,-0.0030532768,0.0032175158,-0.01555582,0.07512733,0.0014382718,0.029548183,-0.057378866,-0.040446885,0.024326025,0.0019359614,0.11662466,-0.039221812,0.034147017,-0.025684517,0.04306924,0.042450562,0.08505889,-0.06474714,0.03086233,-0.07155702,0.007949921,0.014945706,-0.027024135,-0.048562992,-0.007654783,0.06559876,0.03576897,-0.04820691,0.087179914,0.024389561,-0.039778877,-0.0072602173,0.054576337,0.082543105,0.057456538,0.04181648,-0.055725027,-0.012472457,-0.021379521,0.05246913,-0.049837187,0.0154110305,-0.033132017,0.020290062,-0.09413139,0.094886735,-0.005436814,0.058063205,0.081683256,-0.0053772395,0.013274395,0.06129754,-0.04123143,-0.04716343,-0.053411424,0.06422874,0.035764564,0.086918175,0.028043676,0.037616756,-0.036101382,0.014643296,0.02952759,0.013539524,0.002549978,0.01103622,0.07867651,0.0054442245,0.012397522,0.06587512,0.028932365,0.040373903,0.009295121,0.037996665,-0.044504806,-0.004543597,-0.15095527,5.1822186e-33,0.0204132,0.03839929,0.008573726,-0.009289861,-0.038241763,0.0024099757,-0.092086054,-0.054132715,-0.0890635,-0.04419958,-0.08254899,-0.0703054,0.100884624,-0.020905923,-0.02864965,-0.072923146,-0.038824238,0.047063567,0.055325914,-0.0781064,0.030928629,0.091051064,-0.040156044,0.05428409,0.04178364,0.03817814,-0.03761813,-0.012337616,0.110669754,-0.033962313,0.09299516,-0.07030566,-0.06255087,0.0033556398,0.021164892,0.013524715,-0.042969313,-0.05098828,-0.027044617,-0.005438303,-0.09547063,0.046709854,-0.053710822,-0.024542555,0.06472749,-0.07470669,-0.07291871,0.017861184,0.034948956,0.010058951,-0.0014041372,-0.05575438,0.020281756,-0.046816297,-0.053217445,-0.008359919,0.019305354,0.044113472,0.0586456,0.019603712,0.048532743,0.038892012,-0.06548922,0.014473717,0.05759992,0.07131074,0.03284517,-0.041737862,0.02578349,0.05748055,-0.055947624,0.027053956,0.031915635,0.01818941,0.06834075,-0.06776518,-0.041899398,-0.09784555,0.012596936,0.029109592,0.0029214127,-0.014396393,0.06492735,-0.026682505,-0.008524589,-0.05372103,-0.10734424,-0.078085825,0.04459244,0.024537247,0.038987473,-0.009683812,-0.038208995,-0.05075864,-0.047066584,-5.5517753e-33,0.053107075,-0.052210733,0.013526601,-0.08541242,-0.08837691,0.07581307,-0.025258223,-0.041239876,0.07749931,0.0041787624,0.09042034,-0.026319925,0.0865303,-0.102161355,0.016301973,0.025493361,-0.024951499,0.028793197,0.091764025,-0.008242331,-0.014884029,0.019661883,0.0055394527,0.08562689,-0.0004351924,0.013078857,-0.0432326,-0.05182713,0.09955295,0.04696732,-0.035851594,-0.06966799,-0.055153638,-0.007133323,0.042251326,-0.0072473153,-0.02291744,0.021377387,0.007812018,-0.04110565,-0.015470311,-0.0027690665,0.038106803,0.08867215,0.0031859817,0.06751944,-0.03957158,0.06842598,-0.05138517,0.01413295,0.0025919261,-0.008922293,-0.09891038,-0.0054138605,0.068991326,0.043230757,0.09068373,-0.01435682,0.012698305,0.00020530581,-0.017079545,-0.14145426,0.06195245,-0.0056516402,0.06675495,0.010382621,-0.027550243,0.047977407,0.046283916,-0.00490514,0.07068386,0.04835543,0.05889893,0.009556087,-0.027722845,0.00964054,0.029039158,-0.04448137,-0.026155096,-0.019947719,0.027661014,0.051001716,0.027262896,-0.07579723,0.059502475,-0.04849336,0.06511941,0.07351081,0.025038261,0.03270186,0.01930315,0.017424978,-0.013870114,0.003853419,-0.01845142,-4.6657938e-08,0.049294516,-0.03674561,0.024888668,-0.07619778,-0.0051173945,0.072614886,0.06301079,-0.00089566957,0.0007923111,0.018784052,0.027191395,0.047692213,-0.013877863,-0.08652315,0.076888114,-0.015559362,-0.060159422,0.03168458,-0.038556267,-0.004649017,-0.05634141,-0.010657405,-0.13047253,0.0231869,0.021173522,-0.050039228,0.0075356243,-0.059020575,-0.04951569,-0.08243792,0.0073010814,0.012455813,0.05198495,-0.0031834135,-0.07387158,-0.00030411017,-0.007826416,-0.015036036,-0.047985654,0.034801677,0.013645938,-0.018164253,-0.010970211,-0.017933222,-0.024531832,0.055000745,-0.03486247,0.0039404077,-0.046946034,0.030314423,0.021362565,-0.041521456,0.036808614,-0.0053961533,-0.12040925,0.07651814,-0.048143398,-0.041245583,0.070064284,-0.061417814,0.011438441,-0.025172325,0.123700425,0.03139968 +1.2.99.3,"A quinoprotein. Wide specificity; acts on straight-chain aldehydes up to C10, aromatic aldehydes, glyoxylate and glyceraldehyde.",384,0.9999999,-0.019541897,-0.040417884,-0.0010233317,-0.04673561,0.06468513,-0.0063682916,0.051765546,0.0036584286,0.025577327,0.027527157,0.041039396,0.008904486,-0.061370764,0.032329626,-0.027683634,0.071290016,-0.038854793,-0.02391073,-0.041691385,0.0040987567,-0.07199981,-0.039037354,-0.093932055,-0.009934928,0.04062654,-0.04009034,0.02224123,0.05147418,-0.006022025,-0.008624087,-0.029527491,0.012822943,-0.020337954,-0.00026740332,0.010561953,0.052865725,-0.041128054,0.025965644,0.0303216,0.025709437,0.027974065,0.034500573,-0.0038363258,0.020135788,0.0278382,0.037491646,0.028043363,0.13248508,-0.07672746,0.12678695,-0.047116708,-0.078070536,-0.044788413,0.08580294,0.024411915,0.02459005,-0.097457804,0.03448146,0.0042307964,0.07146016,-0.0073118554,-0.03516475,-0.010164427,-0.008618299,0.017541219,-0.039197806,0.038722504,0.01381864,0.019035958,0.011159917,-0.012156264,-0.022884937,0.007840402,-0.030109752,0.07824295,-0.033445723,-0.09324942,-0.011233783,0.05397144,-0.017772712,-0.016257912,0.08241943,0.057493586,0.06718289,0.037969846,-0.027775945,0.078353494,0.042840313,-0.06556179,0.010385004,-0.0010184987,-0.08180303,0.010534536,-0.09805173,-0.013925441,0.07485441,0.029346198,-0.0299231,0.038329605,0.006815224,-0.01631455,-0.071745634,-0.006674769,-0.09250764,-0.11615283,0.054728154,-0.015294864,0.052842014,0.04475199,0.0053597908,-0.05604403,0.0012082979,0.043853167,-0.10073847,-0.0513417,-0.0147140995,0.014528648,-0.09530643,0.030561302,-0.037445087,-0.0070421207,0.049377054,0.059396777,0.036573116,-0.01872327,0.04112176,-0.02453616,3.0864518e-33,0.041554485,-0.00094480906,-0.0053252773,0.09043002,0.013916365,-0.014973285,-0.07078685,0.03415995,-0.108518526,-0.001768722,-0.012054698,-0.04024469,0.04658131,-0.0007796456,0.0019108842,0.10735772,-0.026755331,-0.054548796,0.052119467,-0.07796238,-0.025701556,0.054262754,-0.093084216,-0.019557906,0.016546616,0.021053625,-0.00828387,0.024104824,0.0025488338,-0.015829261,0.01126688,-0.002384195,-0.022310415,0.03198601,-0.014534711,0.020239294,-0.061575674,-0.05303683,-0.047792967,0.034228645,0.013709668,0.055880107,0.0084890155,-0.05907849,0.026101096,-0.007962827,0.014825474,0.049808357,0.008091674,0.027301852,0.060562044,0.00058708934,0.02951856,-0.047492415,-0.16966781,0.07640058,-0.03920359,-8.693987e-05,0.035480145,-0.008210724,-0.03188968,0.036791336,-0.027454428,-0.09583495,-0.034380075,0.034270223,-0.048507746,-0.052103046,0.09800102,0.075134024,-0.042818304,-0.027223255,0.07909157,-0.017829252,-0.022025589,-0.012803208,-0.05602213,-0.042568684,0.03457234,0.045224573,-0.033911735,0.0105251735,0.054268982,-0.053865544,-0.06114021,-0.11855287,-0.022668798,-0.05178511,0.02281353,0.012296444,-0.015337705,-0.0038020904,-0.020025661,0.034387253,-0.018398898,-4.1039384e-33,0.07006871,-0.13295056,0.0032037203,0.03443459,0.027862374,0.034539577,-0.037167426,-0.015377834,-0.011984507,-0.0025746406,0.11916232,-0.038642023,0.010382868,0.033247177,0.049954668,-0.015997624,-0.025429897,0.020870911,0.055511933,0.008345098,0.0012984595,-0.007526347,-0.011683082,0.03556339,0.033837583,0.06603029,-0.032622416,0.014018258,0.14098786,0.102701254,-0.08487189,-0.040146954,-0.025240907,-0.044897735,0.03582215,0.039024554,-0.037621748,0.048212625,-0.059648324,-0.0005970307,0.012001659,-0.0009506467,0.06377287,0.086573765,0.008433656,0.03978914,-0.077314585,0.052660204,-0.0576529,-0.026101166,0.013903055,0.06411632,-0.060523443,0.037120875,0.034275018,0.13510075,-0.056386583,-0.047253214,0.025380502,-0.01818406,-0.10095374,-0.11735403,-0.0007566339,-0.034665253,0.0063818,0.09191841,-0.113138236,0.036149073,0.015011735,-0.017120022,0.032401342,0.034924034,-0.021958714,-0.002018134,-0.0041261865,-0.07305846,0.018626312,-0.07140433,0.0028866616,0.06922587,0.06759616,-0.019889064,-0.03416511,0.017435618,-0.014639403,-0.07336025,-0.0065974295,0.1564637,0.0025919524,0.010357937,0.0272803,0.016207878,-0.06515875,0.025139172,0.03446359,-3.2887808e-08,-0.052521385,0.005032001,0.038357925,-0.005470855,-0.044702083,-0.0064024976,0.081953794,0.06346053,-0.03850867,0.02555756,0.06032345,0.054109134,-0.04874436,-0.030703403,0.046622574,0.0030955595,-0.110156745,-0.033214606,-0.054287314,0.05865147,-0.0811111,0.039874166,-0.08882609,-0.004819632,-0.061684642,-0.054014865,0.015721526,0.01687247,-0.09812273,0.011422204,-0.01695573,0.09313776,-0.071649015,-0.015674908,-0.08299987,0.040457673,-0.013136784,0.035219196,-0.03982733,-0.035486445,0.040985364,-0.032939345,-0.09673541,0.013936936,0.016545108,-0.08022694,0.020230014,-0.030573199,-0.037572626,0.056055706,0.07294196,0.04383453,0.04616841,-0.004703451,-0.04110367,-0.044134878,0.0037342221,-0.057388376,-0.03974103,-0.025833769,0.04155119,-0.006326996,0.20165567,0.044966117 +1.2.99.4,"The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. The enzyme from Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, NDMA-dependent alcohol dehydrogenase and EC 1.1.99.37, NDMA-dependent methanol dehydrogenase [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2].",384,1.0,-0.088309236,-0.0007566748,-0.085434966,-0.016941426,0.08488108,-0.0041754628,-0.06807072,0.03566049,-0.030242473,-0.0034779722,-0.029545408,-0.034072082,-0.040495504,0.03831869,0.018012103,0.051014278,0.046875503,-0.034273565,0.050293956,0.029939389,0.022620792,0.07786774,0.011570349,-0.087013476,0.06665187,0.041947097,0.08919068,0.049435213,-0.020740723,-0.08331094,0.010389512,-0.0323863,0.010646726,-0.060695253,0.13102797,0.027908703,-0.05425832,-0.09000534,0.024449985,0.031554185,0.08541846,0.07602396,-0.009138391,-0.008996992,-0.017221216,-0.03183465,-0.010158942,0.056568626,-0.062937304,-0.029078295,-0.030299881,-0.00042377147,0.009212027,0.013733945,0.06289297,0.008562311,0.009639836,-0.025364216,-0.02791217,-0.010434911,0.020331696,-0.040714324,-0.0011128826,0.0034759114,0.095736675,-0.056387205,0.034157343,-0.04166827,0.037450228,-0.022472713,-0.11816642,-0.042133443,-0.0058540995,0.022464825,-0.018565869,-0.01833398,-0.053384412,-0.067644835,0.07769399,-0.0010786626,-0.069360405,0.014692758,0.013701588,0.038584348,0.049916405,-0.020420216,0.07235264,0.02976353,0.004853246,0.09763974,-0.007196071,-0.0560123,0.019642916,-0.022390315,-0.119020246,0.011237511,0.088361025,0.09410814,0.034287997,-0.07468746,0.02670187,0.11450959,-0.0024551915,-0.06633475,-0.061205193,0.0529397,0.0065300195,0.11267689,0.053978935,0.06760504,-0.039568476,-0.026040407,0.048965573,-0.040869363,0.0028322504,0.062992126,0.049287573,-0.07090851,-0.07869494,-0.055213228,0.037020013,-0.086088054,0.052981272,0.011903533,-0.04588319,0.07612839,-0.115154296,4.576473e-33,0.067518935,-0.031028181,-0.06332057,-0.0107762385,0.019141493,-0.04308752,-0.09118969,0.058354113,-0.051545154,-0.0026962885,-0.053175118,-0.038433637,0.06146269,0.0012501149,-0.109858334,0.07052437,-0.030114925,-0.038267605,0.037930988,0.086957246,0.020318845,0.009271607,-0.022077916,0.031756777,0.009975296,0.038256016,-0.038447775,0.06395109,0.010527395,-0.012658928,0.03492276,-0.12651746,-0.065059416,-0.025184574,0.04166794,-0.019141275,-0.056735367,-0.048921376,-0.010734455,-0.010526088,-0.033028424,0.021220809,0.037865125,-0.033779707,0.023366941,-0.035251614,-0.036715332,0.030670969,-0.010340997,0.039895266,0.05478723,-0.06257336,0.07979041,-0.065836705,-0.049898114,0.0041955896,-0.024389053,0.03651371,0.049133085,0.049028907,-0.010916587,0.030640215,-0.043361288,0.07595465,-0.025806924,0.021924123,-0.048811305,0.0044784164,0.07282224,0.01440703,-0.036599115,0.04529906,0.04815495,-0.0056463405,0.04063371,-0.026193503,-0.012507973,-0.025384372,0.07509161,-0.0044608884,0.030971134,0.042267527,-0.019239359,-0.050941195,0.016521672,-0.054878287,-0.08751643,-0.0435423,-0.012843577,0.009247561,0.0010751148,-0.07650238,-0.011541954,-0.012850025,0.016427329,-6.055895e-33,0.11206567,-0.08173307,0.08569202,-0.14860135,-0.03168708,0.053436805,0.026863739,-0.024998039,0.06655628,-0.040984124,0.071955584,0.0035911999,0.09851283,-0.01606479,0.038873486,0.008564814,-0.06536571,0.07785855,-0.047185525,-0.07245542,0.039598517,0.09187877,0.025161333,-0.02987339,-0.012461252,0.012194928,-0.047250446,0.015818981,0.08758928,0.068011574,0.0041731508,0.02074659,-0.0845232,-0.08606155,-0.029223,0.025114086,-0.08028261,0.0013015496,0.009133424,-0.041054327,0.016670676,0.028875861,-0.026021665,0.043378603,0.055161208,0.008049128,-0.12569594,-0.04366458,0.033300605,-0.016561572,-0.0076806797,0.006115529,-0.05503285,0.02547802,0.051839814,0.065947965,0.0534288,-0.019848306,0.062380597,-0.013122328,-0.061570026,-0.01213245,0.058235165,0.01236948,-0.0014074787,0.031987038,0.036731213,0.0911871,0.0421489,-0.029483885,0.078264035,0.024434552,-0.045844983,0.059092287,-0.005704466,-0.048743505,-0.055077616,0.08208024,0.007867137,0.008926995,0.027250063,-0.008268113,-0.0135742435,-0.03849528,-0.0038314892,-0.05390084,0.039957576,0.049273755,-0.0433874,0.03592387,-0.019812066,0.05931618,-0.033875838,0.05476523,-0.021013565,-4.6101903e-08,-0.008351599,-0.031861227,0.09691398,-0.016693477,0.054026827,0.055097915,-0.016132453,-0.051603463,0.06511944,0.036863413,0.07927675,0.08125925,0.006213785,-0.016807359,0.006993231,-0.02227635,-0.082030974,-0.075210206,-0.03965608,-0.05037486,-0.051280543,-0.019156057,-0.03657834,0.10445828,0.018363832,-0.05587328,-0.02050125,0.008190182,0.022273207,-0.04328577,-0.052511774,0.08754548,-0.019364713,-0.070105195,-0.1093673,-0.034912817,0.011848197,-0.05344872,-0.03650634,0.044305693,0.026974631,-0.09533983,-0.055775505,0.00955126,0.008633341,0.038379863,0.014851723,-0.061305948,-0.10451453,0.022381851,0.038137145,-0.039883506,-0.025466572,-0.012574917,-0.0719886,0.042978507,-0.018729603,0.0047748066,-0.0025655807,-0.05712443,0.043997526,-0.002819371,0.13216414,-0.042183664 +1.2.99.5,"A molybdoprotein containing a pterin cofactor. Tungstate can substitute for molybdate. The enzyme catalyses a reversible reaction in methanogenic bacteria, and is involved in methanogenesis from CO2 as well as the oxidation of methyl-coenzyme M to CO2. Methylviologen can act as acceptor. Also oxidizes N-furfurylformamide.",384,1.0,-0.06379545,-0.024259383,-0.04005245,0.06556895,0.064917766,0.03358037,-0.05592551,0.013454534,-0.06548577,-0.070379294,0.02157152,-0.018486986,-0.06547694,0.040881217,-0.019223247,0.09587502,-0.02741792,0.01261647,0.032116804,0.049460996,0.024153622,0.014421471,-0.006144999,-0.029153826,-0.02350959,0.039303202,-0.020633847,-0.044869594,0.06148301,-0.013224008,0.01744519,0.041352734,0.019650878,-0.04310874,0.037535425,0.05562206,0.08009774,0.027310573,0.022397505,0.02786045,0.003020347,0.0593238,0.08621941,-0.049162876,0.010963719,-0.026658118,0.051629778,-0.007121229,-0.08749977,-0.0070657125,-0.04731432,-0.084862486,-0.06377232,0.03486035,0.058310203,-0.028051471,-0.03420221,0.03384304,0.06348173,-0.046885524,0.0021104033,0.032318108,0.060021907,-0.0008681726,0.031505372,-0.097076006,0.019760456,-0.028366588,0.051043894,-0.03097857,-0.064524606,-0.0017421546,-0.02119084,-0.020362493,-0.060387764,0.039101277,0.021076882,-0.045201834,0.10193197,-0.024499554,-0.017842054,0.026229434,0.06653988,0.008750399,0.071072236,-0.032548424,-0.056582853,-0.022025201,0.038529545,-0.03794975,-0.025853924,-0.03517516,0.016175486,0.0020976493,-0.15043393,-0.011824914,0.11559357,0.025502237,0.025657872,0.05679448,-0.047932368,0.051294908,-0.10171134,-0.042149715,-0.093179174,0.00041600372,-0.010592686,0.05978073,0.04855683,0.08139445,-0.021502605,0.06356949,0.043983474,-0.030986413,0.05367352,-0.011741834,-0.033315454,-0.058785602,0.0038391806,-0.0619929,0.021062475,-0.010991815,0.03152234,-0.010410934,-0.06669531,0.050505407,0.019605042,5.8454638e-33,0.14333257,0.041942555,-0.020841602,0.0072874753,0.03603973,-0.054889217,-0.04030809,-0.058392417,-0.010521305,-0.078369536,-0.033901878,-0.043389313,0.03580041,0.002712359,4.534828e-05,-0.05788922,-0.03762159,-0.0032585703,0.06620007,-0.00826987,0.035274513,0.048208512,-0.02218321,0.027642397,0.04767095,-0.004713608,0.029320015,0.045315847,0.038594507,0.00072808436,0.030307613,-0.06902922,-0.10268041,0.003126749,0.013612392,-0.01562513,-0.13144493,-0.068262406,0.007377982,-0.004271063,-0.023815691,-0.017074063,-0.075227775,-0.026389128,0.08559678,0.0012863359,-0.008526736,0.10841246,0.0146746505,-0.008481674,-0.06544357,0.011409235,-0.033612892,-0.04940447,-0.08869673,0.017885413,0.03447888,-0.07265035,0.02953276,0.039692026,0.004898628,-0.013681212,0.012329156,-0.0029749938,-0.05401834,-0.014377041,-0.01993764,-0.060049776,0.040385786,0.07531611,-0.052259035,0.004774807,0.01804479,0.08227795,-0.031780913,-0.11692745,0.08015535,-0.057698786,0.033630494,0.0118044745,0.021316936,-0.0015322648,0.032395866,-0.06059699,-0.014090675,-0.041488715,-0.089380994,-0.07264825,-0.0405777,-2.285789e-05,0.018088575,-0.0446441,-0.024497153,0.025865225,-0.032089066,-5.6543637e-33,0.0995894,-0.07381258,0.07350426,-0.07424796,-0.07927021,0.03093101,-0.018387351,-0.05014527,0.023788951,-0.0801242,0.022446899,-0.03264305,0.08013693,-0.0015533707,0.021220408,0.024584834,0.02303232,0.06270399,-0.0072594723,-0.036576726,0.05302318,0.063002,-0.09206458,-0.030137049,0.014738688,0.040171612,-0.067612186,0.0224931,0.0944101,0.0746487,-0.019551547,-0.021481577,-0.066984326,-0.09609714,-0.059153315,0.078018725,-0.043508243,0.0020976986,-0.03566704,-0.023143522,0.046960033,0.02104016,0.027597094,0.0917508,0.0349424,0.06979163,-0.10840002,-0.03757054,0.07259785,0.0067225597,0.019028716,-0.04335314,-0.017322857,-0.0115657,0.0016878207,0.048327096,0.01922865,-0.073375255,-0.0037569504,-0.02243484,-0.037162952,-0.057500686,0.07396537,0.043620963,-0.007550747,0.09611427,-0.0011285245,0.029615864,0.08807319,-0.052763578,0.06849579,0.076398686,0.033314217,0.013884765,0.0334697,-0.078422725,-0.07796699,0.027591653,-0.042348746,-0.006253932,0.0067455363,0.06061101,0.060707483,-0.050809164,0.0042838785,-0.0076210164,0.0009030599,0.1063911,-0.0040812897,0.0050967806,-0.0829651,-0.024439244,-0.01115407,0.057824,0.07487126,-3.8520614e-08,-0.06413352,-0.08897908,0.073430456,-0.06761113,-0.045440488,0.07938359,-0.0024633983,-0.041368116,0.021419542,-0.04274577,0.057400487,0.10063083,0.022524392,-0.052321725,-0.0007609986,0.072309576,-0.06573747,-0.02860887,-0.04715794,-0.011920708,-0.022226412,-0.0012284832,0.0038455743,0.12699766,-0.0035574632,0.013724955,0.018914869,0.14358743,-0.038679004,-0.008169022,-0.029365204,0.037475325,0.012219211,-0.012277913,-0.050777268,-0.0036727323,0.017550997,-0.049507517,-0.0885239,0.046390384,0.020312166,0.03268808,-0.05531946,0.056479383,0.08546574,0.0014165482,-0.05028786,0.015334234,-0.053205438,-0.019235568,0.041938152,-0.012965245,-0.012977998,-0.017709868,-0.12603109,0.045059107,-0.023968875,-0.034688212,-0.049401075,-0.0059312917,0.02071354,-0.02849457,0.17663829,-0.025905129 +1.2.99.6,"A tungsten protein. Methyl viologen can act as acceptor. In the reverse direction, non-activated acids are reduced by reduced viologens to aldehydes, but not to the corresponding alcohols.",384,0.99999994,-0.00037548898,-0.01792719,-0.019624356,0.04762022,0.088454396,0.088115126,0.014173395,0.0005066929,0.0048013525,-0.04798798,0.073341966,-0.035442334,-0.06140217,0.023815578,-0.013554963,0.077899754,0.0018316976,-0.019522397,-0.045253392,0.031005124,0.021181533,0.017627316,0.02141996,-0.052072868,-0.009834871,0.10423655,-0.018630115,0.042662088,0.1069794,-0.04693295,-0.0021023452,0.029655479,-0.0053066523,0.019948555,-0.01328957,-0.026712803,-0.027337883,-0.038399737,-0.013151588,-0.012545769,0.011682482,0.01307205,-0.019428575,0.0052094054,-0.045707572,0.025888002,0.03531966,-0.01835063,-0.027253678,-0.019609893,-0.017530443,-0.038608976,0.0040211547,0.06941729,-0.0750933,-0.012793528,-0.033630095,0.021577274,-0.023650477,-0.04308089,0.052853037,-0.024349488,0.019603942,0.0058226176,-0.010600177,-0.02613804,0.011748181,0.042563967,0.023126548,-0.011812877,-0.027576718,-0.044808302,0.009533334,0.04867974,0.018852891,0.029930893,0.010971954,-0.026357805,0.0699526,0.061352383,-0.035516515,0.0067836726,0.022001607,0.11310132,0.057113033,-0.04697298,-0.06731822,-0.037384514,-0.035503715,0.02641031,-0.07438373,0.00044448726,0.050848186,-0.06463727,-0.01937448,0.018476339,0.10949496,-0.033573166,0.03701287,0.040474683,-0.054403286,0.030310757,-0.051925603,-0.09944505,-0.045609985,0.0470763,-0.04458243,0.061960656,-0.028885463,-0.008751699,-0.009320693,-0.0025987837,0.09063759,-0.010440008,-0.032944195,0.043658674,0.06973963,-0.07150348,-0.052905925,-0.09277505,-0.03389302,-0.024729436,0.10355354,0.008118229,-0.054487355,0.007867915,0.0054305634,-1.0185509e-34,0.004790055,-0.042008374,-0.018923607,-0.049741674,0.0074606384,-0.052135777,-0.022537293,0.031495094,0.0065332036,-0.041400965,-0.050373316,-0.048186906,0.08705945,0.07746719,0.021938331,-0.014330067,0.012779167,0.0075164917,0.02346604,-0.071898,0.024974182,0.10501519,-0.010271804,-0.0123360455,-0.08495617,-0.009721163,0.02015944,-0.054193284,-0.010004423,-0.047252778,0.0009709324,0.06158301,-0.032882713,0.018769493,0.013750884,0.10263788,-0.06172329,-0.020958297,0.021088313,-0.04577089,0.069787204,0.06457695,-0.10695311,-0.016589537,0.08210266,-0.03019548,-0.03350893,-0.0057136477,-0.057135954,0.00935492,0.008075581,0.012798705,-0.04745406,-0.04263072,-0.09748438,0.010962342,0.095225796,0.03132659,-0.09368727,0.001597011,-0.06465012,-0.028073385,-0.03750581,0.045620758,-0.034689777,-0.08604218,-0.032390673,-0.10656577,-0.061681096,-0.005872466,-0.03140705,0.021105101,0.025224289,-0.029041182,-0.018704146,-0.080634244,-0.09205224,-0.044844277,0.027393287,0.008606375,-0.054793436,0.031175612,0.0016884838,-0.069842055,-0.08445034,-0.08829347,0.03615702,-0.077605456,0.03340691,-0.052022208,0.04159248,-0.041471727,-0.012591293,0.010428491,0.067919254,-1.8944812e-33,0.053059787,-0.052172944,0.023378348,0.040311318,0.01844772,0.09309394,0.06360507,-0.012211101,-0.00045511127,-0.06261566,0.156203,-0.020657046,0.004861284,0.024737956,-0.0006692424,0.03925,0.025998032,0.09545755,-0.016573101,-0.0075633004,0.016820477,0.0798887,0.023801416,0.044678524,-0.01243427,0.039551236,-0.007987479,0.023657963,0.036612704,0.10590642,-0.000842637,0.064804815,0.011254964,-0.07849049,0.039977636,0.001430531,-0.049788363,-0.030543247,-0.06178134,0.024580538,0.051850077,0.029153824,-0.062821776,0.08840256,0.034259506,0.06340145,-0.111438915,-0.024476634,-0.012291832,-0.087141246,0.08570374,0.0041617043,0.014640991,0.034136463,0.042102057,0.08505169,-0.0061659035,-0.08205453,0.0027380479,0.055541042,-0.062127583,0.006168564,0.049988966,-0.058049973,-0.027066883,0.010375016,0.040889464,0.09422207,0.058686204,-0.12653378,0.14907674,0.10619888,0.08556543,0.02150556,0.089377865,-0.1112773,-0.0051512015,-0.024733622,-0.06842634,-0.07844219,-0.04785481,0.07973818,0.026390858,-0.0687709,0.006978299,0.011882174,-0.08134059,0.0066094156,-0.034543242,0.06374736,-0.0018404579,-0.016972326,-0.021371426,0.043894626,0.07094846,-3.345466e-08,-0.010943919,-0.0276519,0.025766771,-0.0097961165,-0.110302195,0.059199702,-0.0056882547,0.024578191,0.042697445,-0.011697671,0.029690815,0.05740635,-0.044335496,0.008651785,0.0058335317,-0.0024478838,-0.08223741,0.016742475,-0.06537443,-0.009180164,-0.040575195,0.024090504,0.011351615,0.008453784,-0.0114349825,0.020323459,-0.021074517,0.016978905,0.009736963,-0.0065487246,-0.0054338495,0.09067297,-0.016254593,0.029925799,-0.062299997,0.026381144,0.10098837,-0.025206506,-0.11253621,0.014476663,0.040346276,-0.023961065,-0.13147064,-0.022581529,0.04948177,0.046393972,-0.017077453,0.0469929,-0.010023234,-0.0122853555,0.06457443,0.016492587,0.007529269,0.0068492587,-0.15052097,0.02724342,-0.02210284,-0.005655082,-0.04544395,-0.08783851,0.043573983,-0.08093137,0.14689586,0.0124641955 +1.2.99.7,"Belongs to the xanthine oxidase family of enzymes. The enzyme from Desulfovibrio sp. contains a molybdenum-molybdopterin-cytosine dinucleotide (MCD) complex and two types of [2Fe-2S] cluster per monomer, but does not contain FAD.",384,1.0,-0.06830326,-0.104269624,-0.05937837,-0.03699599,0.10958956,-0.028146744,-0.057581402,0.041037366,-0.011457809,-0.058058873,0.06517558,-0.031522952,-0.020908585,0.0078060096,-0.039073847,0.042580135,-0.0736198,-0.0054796333,0.0067136735,-0.0016741772,0.08310187,0.025531251,0.041912552,-0.0369689,-0.039304286,0.11975579,0.055466376,-0.02504785,-0.004575466,-0.048788115,0.04826283,-0.020199178,0.045717336,-0.012747687,0.06818426,0.08049355,0.08295821,-0.0046594124,0.033560432,-0.06384955,0.021628067,0.053252026,0.08124778,0.0053241667,0.020399645,-0.03527965,-0.046340868,-0.006567017,-0.0078009986,0.018095622,0.0032436503,-0.05366663,-0.042606935,0.068984725,0.07193296,0.05628202,-0.037416376,-0.012852954,-0.0059176153,0.034191526,0.078613035,0.02384084,0.04821462,-0.0116420435,0.05159666,0.018780012,-0.0016899966,-0.049323883,0.042733524,-0.08884276,-0.034885127,-0.024770582,-0.01949105,0.062927574,-0.041517053,0.06687859,-0.007557499,-0.07257476,0.056115814,-0.05366389,-0.04150712,0.018576507,0.118732035,0.081528634,0.023344,-0.06329331,-0.0019049589,-0.03324418,-0.0022674524,0.055119313,0.014627823,0.022199826,-0.025105454,-0.007001277,-0.06620697,-0.0058176788,0.0660888,0.09958071,-0.026536105,0.007453243,-0.030749813,0.07045071,0.004695067,-0.06078109,-0.081796296,-0.062337242,-0.02394006,0.06887252,-0.02835402,-0.023388572,-0.049051747,0.05070963,-0.0042214436,0.030678872,-0.0035678712,-0.0007081808,0.056307998,-0.026829852,-0.026990708,-0.039289113,0.028135192,-0.0054804534,0.0002457682,0.08865192,0.00038755522,0.015940784,-0.12889571,4.2498646e-33,0.01744421,0.02347146,0.03416652,-0.019825306,-0.011619604,-0.016039545,-0.040837318,0.106683746,-0.030730706,0.0055070487,-0.06721103,-0.048444238,0.030170348,-0.030027337,-0.0031108006,-0.063155405,-0.063507535,-0.01210199,0.07765873,-0.072738744,0.030480666,0.102795236,-0.020518098,-0.036087554,0.0017824199,0.02297382,-0.02061121,0.02448577,0.11548089,0.02489291,0.009328384,-0.111080125,-0.09915098,0.021856138,-0.024590528,0.04922656,-0.05549664,-0.10631836,-0.04430357,0.024583386,-0.06340599,-0.02441129,0.025575327,-0.0756891,0.046155237,-0.10126085,-0.086278096,-0.005008514,0.035952307,0.01808865,0.012284723,-0.07698218,0.038628723,0.03439449,-0.01149939,-0.00858098,-0.03805376,0.06525515,0.039978784,0.08764878,0.03977707,0.026981486,-0.02702791,0.042647567,0.0573899,0.013360256,-0.015196499,-0.031280894,-0.033615638,0.12705106,0.008034529,-0.02898623,0.071318895,-0.030208373,0.031784,-0.0755906,-0.00869686,0.004567451,-0.010588475,0.040512778,-0.033656064,-0.046737842,-0.013640804,-0.053108517,-0.024717124,0.024825227,-0.06978233,-0.022567766,-0.039936822,0.07600331,-0.015994038,-0.043181967,-0.082644135,0.017643968,-0.01671248,-4.47211e-33,0.011067762,-0.052605115,0.09202216,-0.08595473,-0.057374533,0.05595655,0.034265902,0.0015630443,0.048674777,-0.027373211,0.08840014,-0.0071443804,-0.018721633,-0.105573654,-0.0062208646,0.07492572,0.021405883,0.0535376,0.045619667,0.008540205,0.027893735,0.10705814,-0.001622161,0.03626316,0.065017,0.04084845,0.0109209735,0.0643456,0.05934689,0.03372759,-0.025645982,0.036973342,-0.04635601,-0.00043637492,-0.07918033,-0.03776495,-0.08612893,-0.003761576,-0.028590873,0.027103351,-0.053475127,0.0654243,-0.012219439,0.17311707,0.051540256,0.05909557,-0.055085562,0.007004828,0.083808206,0.01311042,-0.010235904,-0.06618615,-0.03833291,0.048962273,0.02354988,0.059868034,-0.008458433,0.08422179,-0.056804456,0.0032935468,-0.0077503817,-0.063947424,-0.016351286,-0.0484304,0.0859487,0.008898109,-0.013658831,0.08048004,0.006997702,-0.008429737,0.080271356,-0.032516226,-0.0466926,-0.013408997,-0.05776578,-0.01884769,-0.02396857,0.0724066,0.00665248,-0.02363841,0.058756743,0.058203723,0.011204596,-0.0057758,0.02706802,-0.037065793,0.0021771255,0.12380867,0.03305837,-0.0108056255,-0.03286554,0.030453002,-0.009210821,-0.020183377,0.06817008,-3.6137237e-08,0.0023462728,-0.10720224,0.017493851,-0.0688835,0.018134367,0.04033349,-0.04060472,-0.0028844164,-0.027801273,0.024602411,0.040532347,0.071436994,-0.045168307,-0.06439303,0.017623942,-0.044550065,-0.012743395,0.049550965,-0.046020772,0.017152961,-0.019066675,-0.037896626,-0.103091866,0.062362194,-0.036533304,-0.06644299,0.045535427,-0.06189591,-0.023253612,0.016645713,-0.032540247,0.003866276,-0.016149372,-0.026335726,-0.046635326,0.057802506,-0.009850802,-0.07715924,-0.050612006,-0.01746703,-0.033922173,-0.047603816,-0.03150939,0.045553476,0.031280857,0.030794961,0.0018545372,0.026020238,-0.023019439,-0.007528853,0.0016098998,-0.022253776,-0.024180153,-0.09078308,-0.16215591,0.07587852,-0.03126602,-0.060970023,-0.017104486,-0.061887868,0.05993226,-0.046778735,0.15842013,-0.026592445 +1.3.1.1,"An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [1]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [2], Pseudomonas strains [3,4] and Escherichia coli [5,6].",384,1.0,-0.077713646,-0.016993457,-0.118354596,0.080477566,0.07620031,0.027703801,-0.040030137,0.0034595386,0.019073676,-0.01702407,0.020022977,-0.01177207,-0.06421925,0.039165225,-0.14109603,-0.0035298232,-0.034273744,-0.023096332,0.053753167,-0.021951424,0.06889847,0.010716241,0.048731692,-0.05406114,0.014030859,0.028717313,0.05158083,-0.06425136,-0.0081756795,-0.0342428,-0.03481391,-0.035285633,0.06619595,-0.07481065,0.049820855,0.04906487,0.011715681,-0.0409473,0.065622315,-0.0030772134,-0.023960838,-0.011990159,0.020495743,-0.053924266,-0.050197206,-0.013159278,0.019676208,0.04869593,0.0368983,-0.016822837,-0.06915207,-0.054427486,0.00797501,0.024801653,0.023158722,-0.018282877,-0.015764799,-0.061512593,-0.014544833,0.010134884,0.06795679,-0.016583253,0.03338062,-0.060290158,-0.005419229,-0.008919363,0.027265783,-0.07413436,0.029305015,-0.084649235,-0.040311623,-0.012111192,-0.02495691,0.06440964,-0.0069502546,0.0043699695,0.038899567,-0.024914673,0.04271887,0.032288123,-0.0046758936,-0.04199537,-0.0051749414,0.079731934,0.011962252,0.004043552,0.011490915,0.007259028,0.059155103,0.036213934,0.015336472,0.023728868,-0.061475247,-0.08115502,-0.021334302,0.02784157,-0.04316556,0.082246,0.048962396,-0.046875153,0.0034037211,-0.015016975,0.011371588,-0.072616495,-0.02980271,0.013566438,-0.003710403,0.0969018,0.103765644,-0.00056268973,-0.01740691,0.04219947,0.014549556,-0.03052741,0.033091977,0.04559666,0.07922125,-0.06962961,-0.12303192,0.018732348,0.032644622,0.029515581,0.021981081,0.102937356,-0.015821705,0.06410144,-0.12688039,2.6646446e-33,0.060961947,0.079533644,0.0069909794,-0.04123106,0.010771705,0.0086253835,-0.013447069,0.009535375,-0.027214075,-0.0910371,-0.08300972,-0.0629548,0.03371708,-0.04285515,-0.036993213,-0.036770653,-0.03919444,0.002410525,0.071071215,-0.047604598,0.0331211,0.03652568,0.066097885,0.009604048,0.0247062,0.041932747,0.024499482,-0.0013850975,0.013820058,-0.014001201,0.09052094,-0.081858635,-0.07762672,-0.018495832,0.12876633,0.010190816,-0.03024643,-0.04770936,-0.05343703,0.058411185,0.093189046,0.048601855,0.035165835,-0.01939178,0.043827817,-0.0877411,-0.12433414,0.12059428,0.027710844,0.029591268,-0.041139327,0.0061485465,0.11140647,-0.025139628,-0.060629424,0.056029018,-0.025389932,-0.017142072,0.07725791,0.02998508,0.01992471,0.083417736,-0.008596867,0.078364976,-0.057634845,0.0023749014,0.019562239,0.020207165,0.064124525,0.09646741,-0.015218841,-0.0045135138,0.005321755,0.018486237,0.03983835,-0.08639256,-0.13276528,-0.061234176,0.047952037,-0.027451742,-0.009761139,-0.06729996,0.012553508,0.030195002,-0.08862021,0.012806462,-0.09275809,0.010663501,0.0009178948,-0.0019358011,0.010164705,-0.05496174,-0.04434111,-0.014332401,-0.023516357,-3.6241736e-33,0.09118109,-0.09716991,0.094933555,-0.02867137,-0.036408506,-0.00042935513,-0.030613694,-0.032550983,-0.019536149,0.037296746,0.13954417,-0.031666595,0.040372588,-0.07647124,0.062873766,0.09383721,0.02331481,0.007626608,0.047022615,-0.001455598,-0.068416245,-0.01292281,-0.025509082,0.010244161,0.021848539,0.019579807,0.05956391,-0.022602117,0.05349255,0.029163351,-0.07424535,0.064250186,-0.03227591,-0.11091833,0.0006086191,0.055613626,-0.015443382,-0.0049983994,0.08040123,-0.015279923,0.01881344,-0.003391991,-0.023651734,0.08920406,0.021484805,0.03930274,-0.0818082,0.0340488,0.036374822,-0.012051705,0.05216286,-0.021164108,-0.0009082852,-0.02629614,-0.005029782,0.027505107,-0.029933285,0.09740106,-0.06535235,0.03639138,-0.037447985,-0.064752094,0.019990517,0.016287684,0.026490496,0.08019999,-0.07310235,0.0886719,-0.012423562,-0.04773552,0.029398633,0.046419986,0.027942475,-0.0050203595,-0.05746008,0.0032973618,-0.018042287,0.043790776,-0.02235762,0.034096353,0.027733771,0.0036420901,0.017499344,-0.054390546,0.012723538,-0.11700167,0.037806243,0.06516493,-0.04924956,0.041398868,-0.09558077,-0.041642126,-0.10482642,-0.041043583,0.004634192,-4.3740233e-08,-0.01982368,-0.027836671,0.05959922,-0.021083418,0.06598433,0.04969091,0.023869634,-0.012336734,-0.028039679,-0.0013932881,-0.05691145,0.11037716,0.030590896,0.029731179,0.041246984,-0.032371107,-0.06811888,0.03586821,-0.00019837673,0.02878054,-0.017508755,0.033439998,-0.07878848,0.02050645,0.018928165,-0.059127357,-0.018156251,-0.050527256,-0.020548314,-0.045911036,-0.020224845,0.030781996,0.022497857,-0.0300045,-0.06876572,0.034285065,-0.068608165,-0.059481975,-0.06512086,-0.027799726,-0.022043433,0.06370807,-0.05479663,-0.03844247,-0.0078057097,-0.0052905623,-0.0509419,0.02607533,-0.04834539,-0.017235864,0.07891614,-0.019169865,0.022065515,-0.051013593,-0.02908397,0.051670738,0.046419088,-0.159343,-0.00915314,-0.02177358,0.007354412,-0.008673954,0.15806499,0.002745699 +1.3.1.2,Also acts on dihydrothymine.,384,1.0,-0.009617865,-0.041995406,0.03956072,0.021417694,0.03807916,-0.02918645,0.06946863,0.049340148,0.021485109,0.009579545,0.0069971173,0.0048725074,-0.055433024,0.075363345,0.007361104,0.06996815,-0.058839284,-0.0061925384,-0.00566164,0.008744336,0.029884132,0.025502885,0.004934405,-0.02989992,-0.038142297,0.07541407,0.01842518,0.03492475,0.018701924,-0.015949484,-0.006910179,0.018248243,-0.025613625,0.017968172,-0.039997164,0.11918796,-0.04672696,0.0353268,-0.04124465,0.056239527,0.067915566,-0.07141783,-0.02748873,0.0010401964,-0.051674504,-0.03934033,-0.058535576,0.020771815,0.044132136,0.069744475,-0.04305761,-0.032399684,0.048571933,0.08862796,-0.011880342,0.049863923,-0.07600502,0.061464977,-0.043423742,-0.014282684,-0.065671295,0.027068872,-0.053345546,0.010178179,0.07353008,0.004809122,0.029648183,-0.05414206,0.015385778,-0.041837983,0.08200894,-0.06299982,0.056610476,-0.01896193,-0.020768747,-0.0057961554,-0.032142367,-0.09174136,-0.016807582,-0.01254891,-0.035129596,0.037587903,0.031767033,0.018277243,0.07638532,0.0029392235,-0.013759988,-0.06280847,-0.073498,0.040167723,-0.019594453,-0.04656839,-0.052297782,-0.00965568,-0.0498117,0.03255309,-0.016125096,-0.019470656,-0.016850246,0.035002075,-0.023280447,0.055355914,-0.1271112,-0.026939422,-0.024690777,0.0018607265,0.01403401,-0.033086568,-0.09029651,0.024905253,-0.0015207906,0.008828934,0.034814466,0.09536214,-0.029444763,0.10519152,0.014980752,0.010860522,-0.08281139,-0.043273337,0.025204824,-0.074772984,0.012047045,0.037438862,-0.03966619,0.03138226,-0.05547674,-1.7141995e-33,0.041067827,-0.047341313,0.030502552,-0.028100433,0.06714703,0.055781014,-0.051343642,0.012817572,0.06683281,-0.04649122,-0.0095787,-0.026382208,0.06411496,0.018876065,-0.06670253,-0.07566278,-0.037796654,0.031946238,0.06579478,-0.07078005,0.048451636,0.09240601,-0.034791585,0.037333682,-0.07628203,0.047070224,-0.025420569,0.041555498,0.05680578,0.0058453027,-0.0018879493,-0.08007288,-0.0077914633,0.013799415,0.006530297,0.1096855,-0.069826335,-0.0038485655,-0.014223622,0.04892611,0.02596575,-0.017501168,-0.06930815,-0.0004930492,0.016468704,-0.021770554,-0.075379595,-0.024856383,0.0049616396,-0.019849947,0.042930923,-0.046897445,0.09017115,-0.089989975,-0.054324634,0.0048992853,-0.0064913235,-0.120434515,-0.028075973,0.06760624,-0.026097963,0.04140001,-0.033538267,-0.012394749,-0.01475153,-0.048348617,-0.048238985,-0.06113905,-0.048389386,0.013662915,-0.07931781,-0.007837145,0.13259971,0.009256339,-0.034886662,-0.0126388995,-0.03284871,-0.0019900948,-0.03522524,0.010486323,0.028532347,-0.088597134,0.08837044,0.0012036988,-0.013097828,-0.001355051,0.00036793033,-0.13275656,-0.035741594,-0.037551586,0.07018923,-0.064158686,-0.02976001,-0.073294766,-0.0354203,-4.1182894e-34,-0.008116344,-0.07375319,0.027628465,0.035953887,0.036930066,0.07535055,0.023624389,0.022795428,0.015865896,-0.022088623,0.04663611,-0.016413279,-0.10189127,-0.0417661,0.03461428,0.060624965,0.03148042,0.124943085,-0.059000816,0.026200447,-0.0323948,0.11340425,0.03701291,0.10138095,0.06733394,0.028423505,0.013958087,-0.025322426,0.021518286,0.07495718,-0.021445774,0.044524003,-0.10381288,-0.09180875,0.00020935622,0.04717249,-0.06570634,-0.056080427,-0.07277599,-0.039483782,0.021806585,-0.028924355,0.11498507,0.08310307,0.029742954,0.06911422,-0.02642707,0.0052914787,-0.09920303,0.012396232,0.046901207,0.009383071,-0.032659158,0.051834736,0.08258724,0.028080879,-0.018127056,-0.067315325,-0.032409634,-0.006499344,0.015533594,-0.022173034,-0.044059165,-0.019872675,0.03593989,-0.005340063,-0.011128816,0.070640385,0.087392315,0.040902857,0.09915071,0.024424652,0.023559015,0.043078806,-0.097388804,-0.01638402,-0.038694266,-0.036910858,0.0131387655,-0.0523216,-0.052853286,-0.0071310136,0.00022992745,-0.05181165,-0.036189638,-0.092725344,0.0071066734,0.07176046,-0.0583381,0.058423117,-0.036377657,-0.02216105,-0.079492204,0.0620752,0.062327445,-1.7391562e-08,0.061467677,-0.08038149,0.07280144,-0.035932936,-0.0058104987,-0.012907047,0.11571615,0.041437823,0.025734317,-0.03033248,0.002558552,0.09234257,0.11179889,-0.001022463,0.05005119,-0.007538408,0.048203968,0.054313526,-0.074925356,-0.061884493,-0.09021673,-0.014551453,-0.019024022,0.05474254,0.0058276793,-0.024170818,-0.0035156633,0.09936061,0.024732245,-0.027617643,0.032468304,-0.030726435,-0.034093942,-0.04253567,0.0412936,0.030185705,0.04504672,-0.017011696,-0.022137778,-0.0039139916,-0.03958256,0.011556751,-0.0393091,0.08164059,0.007100739,-0.021762598,-0.026868148,0.03397475,0.047451835,0.011554928,0.07575325,0.055484794,0.025850544,-0.061511196,-0.10156827,0.040178306,-0.036717795,-0.06981877,-0.02013398,-0.095700935,0.049382485,0.01995745,0.15999256,0.014358564 +1.3.1.3,"The enzyme from human efficiently catalyses the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent [8]. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3-one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates [9].",384,1.0,-0.0036897054,-0.03949991,-0.041463446,-0.034720104,-0.0035533085,0.06660918,-0.037236914,0.013791631,-0.030648626,0.019046152,-0.009184174,0.03823664,-0.07939345,-0.001768197,-0.0024039093,0.031923298,-0.019608784,0.0011226124,0.028485836,-0.039542947,0.031201532,-0.074838616,-0.008023324,-0.017913396,0.049816463,-0.011486047,0.06337868,-0.0014506691,-0.08479512,-0.039969094,-0.005307628,-0.029262032,0.053774387,-0.07283048,-0.097442694,0.050857116,-0.06431986,-0.03687097,0.016649134,0.0651914,0.034935284,-0.03884065,-0.09176248,-0.011108412,-0.03369351,-0.040092077,0.026286019,-0.009812179,0.034892805,0.03833255,-0.036824744,-0.039410412,-0.011993506,0.05429257,0.006772104,-0.0037498905,-0.06254993,-0.064958096,-0.006061039,0.05076275,-0.014719622,0.016432112,-0.025627617,0.012766301,0.016302226,-0.019233089,-0.0030697882,-0.04077187,-0.07296553,-0.07729081,0.023705658,-0.029107586,-0.047360953,0.011688317,0.004930731,0.045263287,-0.07771453,-0.075376146,0.04041685,-0.058235966,-0.0073318956,-0.032636516,0.00149196,0.12750977,0.03482166,-0.03899287,-0.014948732,0.011227866,-0.017247334,0.020903446,-0.03587867,-0.04688804,-0.0084334025,0.008232449,-0.035970822,0.016729658,-0.032505374,0.008994125,-0.05031029,0.0051511284,0.015459315,0.08005299,-0.0852256,-0.11084454,-0.09312095,0.09547756,0.019263495,0.04835767,-0.014350498,-0.021588078,-0.019353965,-0.04935115,-0.024917088,-0.013079306,-0.016886223,0.11847071,0.041902553,-0.032923818,0.013158624,-0.019030586,0.0005819954,0.022050757,0.07737449,0.055820417,-0.023125762,0.021842461,0.0193597,3.0658098e-33,0.08613918,0.00042257088,0.027932048,0.024905501,0.03256797,0.11788149,-0.0022147074,0.035330072,0.06084611,-0.083837554,0.0024887384,-0.0024643806,0.010995135,-0.0033953802,0.017498607,-0.022351488,0.061981216,-0.007494067,0.10956708,0.023293214,-0.048903372,0.04326196,-0.09757219,0.00053200015,0.029449504,0.07362324,-0.042559266,0.097311676,-0.021011697,-0.00018728159,-0.037803024,-0.051464554,-0.0069315066,0.038535524,-0.002897643,0.02844759,-0.08019524,0.029721158,-0.048287626,0.07402916,0.083142824,-0.082307614,0.0043675867,-0.05224617,0.00014425685,-0.057807386,-0.010466867,0.053218987,0.059850793,0.04817773,0.043709863,0.020205464,0.075533025,0.016909398,-0.056268346,0.0722332,-0.06389796,-0.0409652,0.011993566,0.035316985,0.044677246,0.026172105,0.014878766,0.06171859,0.0016344308,0.008727273,-0.05821315,-0.106849775,-0.14891648,0.09658451,-0.08954749,0.03332115,0.082439356,-0.024894442,0.017617406,0.053461473,0.011880725,0.023372753,-0.0054544164,-0.08518681,0.03928599,0.03123414,-0.004915595,0.0108390525,-0.029788462,0.049469724,-0.029675193,-0.077122405,0.03752357,0.012034464,-0.041235235,-0.05537169,-0.08813735,0.033838212,0.038418695,-4.9879954e-33,0.03170633,-0.077443644,0.025092112,-0.05509617,-0.04251371,0.121681,0.13044608,-0.07469582,-0.009982368,0.05252375,0.040949315,-0.05666859,0.023330005,-0.1061752,0.029593999,0.006518401,0.0041840672,0.045268673,-0.03528809,-0.075139105,-0.013631462,0.18585043,0.001344079,0.057916593,0.072860114,-0.023402218,0.031667504,-0.030635586,0.12445376,0.1320935,-0.03536776,-0.0238403,-0.01296789,-0.04114959,-0.021579526,0.07998086,-0.06713294,0.019707391,0.021621365,0.0132370675,-0.037975915,0.0022288936,0.06270715,0.010501821,0.032883048,0.037830204,-0.018358821,0.024030585,0.016125077,0.028246785,0.02683534,-0.02940467,-0.107453085,-0.039838824,0.038063128,0.05441536,0.018809427,-0.07336903,0.054364145,-0.12277916,-0.07114261,0.0321036,0.04506584,-0.019932702,-4.992709e-06,0.014066132,-0.04471113,0.0017874218,-0.019747352,0.028639032,0.03434488,-0.038145997,0.04769098,0.07751777,0.018356578,-0.0058760988,-0.038284257,-0.021788217,-0.026173977,0.0041291434,0.009844503,-0.040723257,-0.021624964,-0.10160938,-0.04142626,-0.03450147,-0.04049577,0.10758453,0.025346888,0.06990663,0.0026479382,0.012949824,-0.078542046,-0.009569639,-0.044641875,-4.277562e-08,0.10410876,-0.045672048,0.022754006,-0.010867794,-0.04472364,-0.04613394,0.021613939,-0.027932052,0.08399299,-0.06159323,-0.040905528,0.11734621,0.05903054,0.048205838,-0.019416284,0.01655099,0.012183179,0.039062224,-0.010990109,-0.03777453,-0.0566237,-0.04053808,-0.08541725,-0.010226047,0.007769636,-0.044390924,0.016378548,0.059742864,0.0025296046,-0.040530328,0.040194422,-0.016613064,-0.023985902,-0.071907714,0.0025297634,0.05026571,0.017957777,0.04811376,-0.011255267,0.038151182,-0.032614164,-0.083487906,-0.01710442,0.07073588,0.0210413,-0.0060760803,-0.0083473725,0.038704455,0.009703242,0.0672055,-0.099390775,0.050688237,0.013287324,-0.04883012,-0.019711446,0.0157607,0.02463079,-0.12048238,-0.048932385,-0.081014596,0.016914655,-0.0038176002,0.16508423,0.014792124 +1.3.1.5,Requires Mn2+. Fe2+ or Zn2+ can replace Mn2+ to some extent.,384,1.0,-0.096784,-0.012094616,-0.020752551,0.07209677,0.0620554,-0.052611154,-0.03160595,-0.00286591,-0.07498551,-0.045772295,0.0033826197,0.012086066,-0.00032042892,0.045813162,0.009931977,-0.008220198,-0.0061817574,-0.00058267626,0.021373833,0.06646504,0.09663508,-0.03496875,0.04388528,-0.109905936,0.024671262,0.04656153,0.02035071,0.0024741192,0.05177211,-0.045428813,-0.0181126,0.0914087,0.014570826,-0.044662345,-0.0078039416,0.04230108,-0.001966644,-0.011970172,-0.04866913,-0.052183624,-0.054240026,0.017359002,0.08194093,-0.013207335,-0.008455488,-0.05809678,0.12013375,-0.11400004,0.009030428,0.05535777,-0.04023875,-0.019559365,-0.03164986,0.06897088,0.059420433,-0.0012887651,-0.080905266,0.004016481,-0.0426525,-0.028227536,-0.0012168173,-0.050959505,-0.036509518,0.02338909,0.1079468,0.043570597,0.0017420934,-0.045706682,-0.04337199,0.04041172,0.038222134,0.015762651,-0.06722467,-0.025013758,-0.018117793,0.045943834,0.090882525,-0.05794442,0.07466564,0.0008147733,-0.110278234,0.021261014,0.025946941,-0.0008052231,0.11719251,0.09523626,-0.05097361,-0.030350195,-0.07594961,0.012251874,0.030119227,0.075288795,0.05903027,0.043462202,0.024499381,0.034844898,-0.021895248,0.03949393,-0.050567444,0.037916243,0.0010301368,0.06038642,-0.039346907,-0.037722975,0.0031597416,-0.017703831,0.059870113,0.06704956,-0.07123332,0.05899365,0.10847651,0.0065413704,0.028667917,-0.028056217,-0.0059035723,0.00027202704,0.016316563,-0.030894214,-0.030535236,0.014549555,0.03625013,0.034452718,-0.09110834,0.00975153,-0.06331718,0.02162437,-0.07809653,4.7786997e-33,-0.023094071,0.05625478,-0.018014133,0.028847238,-0.006111785,0.067449376,-0.051996965,-0.04665174,0.026369086,-0.050122082,-0.086310305,-0.037333366,0.024674166,0.015859514,-0.012495025,-0.13763551,0.03834291,-0.03688185,0.14786609,0.010711277,0.06709182,0.012406731,-0.015367946,-0.065347485,0.019906728,0.096534096,0.12182661,-0.055008188,0.009005522,-0.007947229,0.016616087,-0.057382222,-0.07253281,0.013252069,0.046111062,0.017264802,-0.045021135,-0.013493175,-0.010066131,-0.066598706,-0.027146304,0.05837837,-0.12525539,0.02667759,0.042762984,-0.088758364,0.032494467,0.090182304,-0.048736136,0.021178842,-0.018973632,0.041161858,-0.040458422,0.010858107,-0.032909,0.0011458758,0.04968895,0.021842847,0.05367087,0.07981107,-0.0259373,0.0083403,0.077314384,0.09528717,0.041206446,0.06573621,-0.046542205,-0.018835386,-0.027566504,0.03185808,-0.014941411,-0.07628818,0.059916485,0.0757269,0.028039053,-0.054186374,-0.057553463,-0.0842889,0.08053647,0.028722845,-0.063161194,-0.008148425,0.014424203,0.010724406,-0.04394409,-0.044242416,-0.019079732,-0.08196947,0.026773103,0.005783343,0.060930848,-0.0798077,0.011170943,-0.04267099,-0.016352562,-5.2416425e-33,-0.088114575,-0.0051617995,-0.012657646,-0.028387407,-0.060426176,0.019658905,0.008158156,-0.17261173,-0.006526565,0.008691684,0.057076357,-0.021186955,-0.0040567787,-0.04280049,-0.03740748,0.009822146,-0.059243593,-0.0030090634,0.11279329,0.006409906,0.03371631,0.13101947,-0.014859537,0.05757549,0.023490429,0.088435344,-0.0596779,0.025248775,0.03803109,0.06736922,-0.0031792934,-0.009032456,-0.063594274,-0.08600277,0.006417445,-0.025872579,0.038908143,-0.006703416,-0.051943526,-0.030113693,0.050674442,-0.038806494,0.013051064,0.11528052,-0.03524069,-0.038281847,0.019084783,-0.05833585,-0.029367538,0.006724374,0.0017512835,-0.02905394,-0.09522481,-0.07600051,0.021461707,-0.034061056,0.05182157,0.032809682,0.047743723,-0.019235471,0.034289107,-0.08304011,0.09812091,-0.07157586,0.05123281,0.009356653,0.023527067,0.061329514,0.048017092,0.008733604,0.088026926,0.083180964,0.116256356,-0.03712423,-0.022983475,-0.013744948,0.0020959813,0.03198775,-0.008322474,-0.094001785,-0.017015943,0.0011412549,0.023405535,-0.012271512,0.023164101,-0.09597035,0.0320876,0.030838965,-0.050492376,-0.007876691,-0.03633914,-0.0074595828,-0.0066470215,0.05498578,-0.08350131,-2.6910934e-08,-0.066834636,-0.054117188,0.0036807861,-0.059021976,-0.022778893,-0.035019126,0.0053157886,-0.043626323,-0.010583451,-0.0019568147,0.047925193,0.053475354,0.049221747,-0.026924962,0.06811367,-0.0020416426,0.015342241,0.026632233,-0.07024393,-0.052313723,-0.06747882,0.010121174,-0.068633266,0.057955742,0.032950018,0.0041176314,-0.020604014,0.007350053,0.07123445,-0.026490083,-0.032188337,-0.0032746408,0.048796844,-0.012196738,-0.013024627,0.03065311,0.018809443,-0.03078241,-0.025453076,-0.06279042,-0.120995164,0.017713776,0.00733205,0.035231277,-0.044650853,-0.09386411,-0.06420337,-0.038933955,-0.02298783,-0.0051250793,0.04978497,-0.03378724,0.027837954,-0.059883006,0.011804533,0.04071952,-0.014690386,0.047294278,0.026106069,0.021033453,0.0503987,-0.038463145,0.02930054,-0.06114748 +1.3.1.8,"The liver enzyme acts on enoyl-CoA derivatives of carbon chain length 4 to 16, with optimum activity on 2-hexenoyl-CoA. In Escherichia coli, cis-specific and trans-specific enzymes exist [EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) and EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)].",384,1.0,-0.028207596,-0.055803943,-0.045534957,-0.03617442,0.012809585,0.0015939281,-0.14686199,0.09835559,0.009067679,-0.03210539,0.01968175,-0.08605057,-0.04441111,0.07975517,0.061153546,-0.003274797,-0.034651548,0.03580775,0.010516817,-0.09624695,0.002496119,0.00867147,-0.01423302,0.017548144,0.021378826,-0.052167688,0.049884595,-0.013469549,-0.06232442,-0.08808953,-0.060187325,-0.05873476,0.002848236,-0.058533665,0.06039478,0.030476391,0.006152286,-0.07935958,0.038467735,-0.016969722,0.027432308,0.0072311643,-0.0549963,-0.020356487,-0.037061937,-0.11731809,-0.032617457,0.053712633,0.05011301,-0.023339301,-0.034685846,-0.022547266,-0.023854198,0.013060645,0.066111706,0.008019443,0.026979377,-0.08286617,0.021104788,-0.0038742246,0.022352682,-0.12676159,0.044353314,-0.026369756,0.002480682,-0.018659826,0.07183776,-0.06836931,-0.062844016,-0.014393823,-0.11463399,-0.059436575,-0.02628313,0.06457777,-0.033137895,-0.00981122,0.0014285039,-0.0128901405,0.023733312,0.0029870458,-0.052665323,0.007863955,0.053326327,-0.0011893836,0.020533131,0.075725496,-0.03722596,-0.00909891,0.0003380361,0.09654514,0.012615386,-0.010621503,0.032018226,-0.06600284,-0.040959585,0.028444078,-8.726831e-05,0.045934755,0.00546073,-0.060083367,0.073571086,0.06829014,-0.06976129,-0.041245174,-0.045119744,0.018503355,0.030118035,0.16608621,-0.045022763,-0.011941026,-0.02239047,-0.044471536,0.07225042,-0.019939166,-0.06887709,0.11435153,0.013474854,-0.024235567,-0.06351436,0.065545656,0.0024013922,0.0115810335,0.08001373,0.04547559,0.029458413,-0.011873552,-0.00042941436,1.2394924e-33,0.06469817,0.04655388,0.050902728,0.058767404,0.042330544,0.02162449,-0.09905093,0.09142499,-0.080041416,-0.06575452,-0.02629456,-0.01936291,0.025950933,-0.002899392,0.041238125,-0.016803373,0.021020753,-0.00014257521,0.048885185,0.0068294103,-0.0009302654,-0.04230605,0.037173532,0.049689498,0.016346544,0.0058524082,-0.0757628,0.0853082,0.015186427,0.018474175,-0.03926592,-0.051326703,-0.028197832,0.062176608,0.057181165,-0.043487612,-0.024372963,0.020474175,-0.016197136,0.09463264,0.10743871,0.0442422,-0.0055473954,-0.069970824,0.024498595,-0.04880574,-0.014516054,0.071511954,0.011113951,0.06247622,0.012820497,0.031090604,0.053211667,-0.11008536,0.04893215,0.032875493,-0.0001900012,0.036178578,0.00797064,0.017614843,0.011912089,0.08866906,-0.020640094,0.051572073,0.010489474,0.059101813,-0.10452782,-0.06638161,-0.07978361,0.07332078,-0.035658356,0.053905252,0.0638609,0.06434494,0.03283293,-0.064621754,-0.12496896,-0.0061596795,0.03753466,0.024996458,-0.06461074,0.016669769,-0.034716733,-0.031077221,0.012278084,-0.042150483,0.033308096,-0.0365146,-0.00023490537,0.07115691,0.059286296,-0.09150451,-0.052252416,0.0009592867,0.09535083,-1.6422729e-33,0.076166146,-0.067055605,0.026998127,-0.10871404,-0.087270476,0.023845805,-0.007412264,-0.027203137,0.114760295,0.03916885,0.12416773,0.077530876,-0.005955036,-0.02541736,0.018327545,-0.005119712,0.008474774,-0.021098226,-0.030294899,-0.0652935,0.0047232932,-0.024173606,0.02617394,0.008484304,0.051693838,0.04673695,-0.032917254,0.027999545,-0.0012800586,0.02976468,-0.04679605,0.016142957,-0.029409766,0.047318812,-0.012710949,0.037337586,-0.08380288,0.064307734,0.07186374,0.037777916,-0.07001461,0.025439555,-0.012462864,-0.014719923,-0.016142469,0.023432953,-0.069277935,-0.016815122,-0.015040059,-0.09289329,0.00019904017,0.03289962,-0.002217292,-0.001173114,0.00067081663,0.004165259,-0.01356428,0.04705413,0.033230744,-0.05792017,-0.03639729,0.042214036,-0.010866841,-0.0014044128,0.040356707,0.009600633,-0.06904552,-0.03291387,0.049654126,-0.034159962,0.038189657,-0.049490705,-0.00017008017,0.04371404,-0.055498224,-0.08890311,-0.022669071,-0.069093086,-0.03227338,-0.011531055,-0.054825395,-0.022644874,-0.03583157,-0.0076718023,-0.033722546,-0.07579302,-0.0073415334,0.10953584,0.02919964,0.037638474,-0.02316884,0.010095829,-0.004930467,0.044471726,0.05336708,-4.192159e-08,-0.017947765,-0.075181834,0.01758663,0.0010718978,0.05530134,0.08607165,-0.032952055,-0.06647587,0.107818685,0.014992388,-0.013396334,0.14141107,0.09996967,0.0070238994,0.052875753,0.007953841,-0.024103824,-0.017377473,0.029344264,-0.059635196,-0.050815023,-0.0256078,-0.05080216,0.025671916,0.00090383325,-0.08333139,0.024687838,-0.002942357,0.005647113,0.03853092,-0.0084934635,-0.03564678,0.050826292,0.03589723,-0.021096699,-0.03708695,-0.0153364455,0.025193907,-0.041219924,0.13928182,0.10469575,-0.051946066,-0.10881442,0.008223198,-0.00033904475,0.05430983,0.0044487864,0.047507897,0.0018600358,-0.0005814076,-0.021358633,0.015138051,-0.0022742304,0.0017366523,-0.033428714,0.03156867,0.0229468,-0.06817695,-0.046118602,-0.021668138,0.02924315,0.058323994,0.14520088,-0.07066441 +1.3.1.9,"The enzyme catalyses an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier-protein] derivatives of the elongating fatty acid moiety. The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18 [3]. The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.",384,1.0,-0.04093165,-0.021089977,-0.083334014,-0.005522291,0.028829508,0.04322576,-0.112661354,0.08331648,0.0207918,-0.047002573,0.040982693,-0.08049328,-0.010462904,-5.557798e-05,0.046232563,-0.0071689966,-0.056071036,-0.004519269,-0.009444482,-0.07424698,0.070433244,0.017596137,-0.020407893,-0.022446053,0.026436698,-0.05963737,0.020839447,-0.06362566,-0.023990631,-0.07619438,0.024721427,-0.1099496,0.056109555,-0.052319445,0.07230544,0.020818383,0.01499461,-0.0694187,0.1840946,-0.0011926255,0.029522827,-0.02279946,0.014503798,-0.0114342915,0.046982016,-0.02713394,-0.041208677,0.077276535,0.021786602,-0.02702086,-0.060997657,-0.035896514,-0.058740877,0.0015268376,0.026265386,0.010467661,-0.016946236,-0.013435618,-0.02087311,0.03271351,0.08535414,-0.078136295,0.0091698095,0.03368426,-0.053913016,-0.089074925,-0.0003357489,-0.11539779,0.033068907,0.040977065,-0.10060528,-0.057025366,-0.07610212,0.034194443,0.013935598,0.025932005,-0.049745206,-0.020682154,0.02285669,0.00906896,-0.025230976,-0.06497089,0.01821426,0.03408948,0.022886995,-0.016064864,0.04325556,-0.027146785,0.0018104058,0.11374277,0.038839445,-0.0932758,0.005250688,0.017956732,-0.094522476,-0.0016449038,0.064215645,0.014733934,-0.031260338,-0.038065337,0.05837918,0.00020029393,-0.03276145,-0.037119653,-0.07159248,-0.0026927465,-0.027927117,0.09399508,-0.029940147,-0.018064694,-0.0077698086,0.006234551,0.05053934,0.017624564,-0.04860618,0.07354462,0.06203323,-0.119355455,-0.01133546,0.0076454733,-0.0079538375,-0.027633222,0.022371287,0.03441873,-0.05487537,-0.018384745,-0.051311467,2.022226e-33,0.0038187765,0.022370277,-0.001965206,-0.05570408,0.07750898,-0.037559528,-0.13419197,0.01345942,-0.08726702,0.012546773,-0.02578879,-0.06585079,0.054925475,0.03552493,-0.012434719,-0.0022779,0.03585359,0.0462088,0.1047618,0.010551533,-0.031295575,0.00885552,0.072350375,-0.00037298154,0.044326164,0.010183039,-0.01835165,0.0135849975,0.01921906,0.020964516,0.00035801373,-0.049095094,-0.06886687,0.012117442,0.07003493,-0.023937304,0.011589753,-0.028395798,0.004897164,0.028533462,0.090897545,0.050393045,0.03413303,-0.03553259,0.04291334,0.04585072,0.013297419,0.053661224,0.011906862,0.023830267,0.05021371,0.009580015,0.08387917,0.006994466,-0.012604163,0.0030800889,-0.06284612,0.016661217,-0.0052069854,-0.0052614124,0.021326937,0.04924275,-0.023819653,0.06742199,-0.06443378,-0.0019848077,-0.051115863,0.002688952,0.0015982651,0.10884343,0.031945184,0.035166446,0.07307416,0.011641653,0.044955313,-0.04152343,-0.11229708,-0.069354765,-0.0019853427,0.00990728,-0.023073673,0.054880567,0.0146084875,-0.065137185,-0.029163718,-0.075916395,-0.080524966,0.018656716,0.064226516,0.010078684,-0.05106159,-0.07599908,-0.012425853,0.08683628,0.0077799708,-3.371706e-33,0.1172041,-0.12720822,0.101467,-0.1096247,-0.036862507,-0.032212228,0.028603585,0.017212413,0.07643449,0.019093847,0.0752527,0.027871933,0.036894593,-0.01309158,0.024991566,0.014049309,-0.05490465,-0.024035348,0.019773632,-0.06980435,0.021188058,-0.05078923,-0.008528254,0.05715537,0.019720374,0.08026731,-0.06700585,0.030177187,0.048894487,0.044737946,-0.033839833,-0.025381569,0.0066676033,-0.038702976,-0.081326105,0.06863055,-0.054471776,0.0652259,0.05594569,0.025239632,0.01508465,0.043927383,-0.016470132,-0.024307828,0.054142997,-0.030363966,-0.031160366,-0.014578799,-0.013748943,-0.13174643,0.0055473438,-0.030117733,0.043979608,-0.021777323,0.042351853,0.07127338,0.007710678,0.04953792,0.021954935,-0.09373702,-0.05650673,-0.054205608,0.0014981022,-0.040205345,0.02893542,0.09667004,-0.010381758,0.021807006,0.009873295,-0.013356914,0.032344684,0.05524213,-0.05895781,0.09727517,0.031924296,-0.050581455,-0.061875917,-0.04584062,-0.041905742,0.006077226,-0.032698344,-0.025229933,-0.025585514,-0.06873556,-0.052345403,-0.053488605,0.036471922,0.10722373,-0.03847137,0.061593857,-0.018161532,0.043245308,0.0013785335,0.051033974,0.06253433,-3.895804e-08,0.024594782,-0.04727076,0.060577046,0.012219131,-0.049825933,0.05398072,-0.0028083196,-0.01019922,0.075475514,-0.07337842,-0.046199184,0.08965741,0.0684682,0.066716015,0.025093978,-0.006942091,-0.09628101,-0.07576417,0.0054569696,-0.061022162,-0.07508677,0.02854857,-0.014845442,0.032720678,0.0065198657,-0.056825303,-0.039715614,0.025836898,-0.032819524,0.04575569,-0.027107405,0.037299458,0.008586713,-0.006656813,-0.010077426,-0.051746722,-0.01085804,-0.1026962,-0.015707577,0.119252525,0.07206982,-0.028355703,-0.053166267,0.003004109,0.023280555,0.0070691057,-0.018493848,0.054551218,-0.022311838,0.006604621,0.06412267,0.00078675186,-0.0499624,0.0090093985,-0.005397149,-0.010654908,-0.06615579,-0.053433206,-0.04769912,0.0044182725,0.063868366,0.014337122,0.18472469,-0.07788729 +1.3.1.10,"One of the activities of EC 2.3.1.86, fatty-acyl-CoA synthase system, an enzyme found in yeasts (Ascomycota and Basidiomycota). Catalyses the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16. The yeast enzyme is Si-specific with respect to NADP+. cf. EC 1.3.1.39, enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 1.3.1.104, enoyl-[acyl-carrier-protein] reductase (NADPH), which describes enzymes whose stereo-specificity towards NADPH is not known. See also EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH).",384,1.0,-0.029494116,-0.013607232,-0.0666089,0.0008714654,0.05818577,0.06252601,-0.10185622,0.052243013,0.028040601,-0.048441604,0.08040763,-0.100925945,-0.09264515,0.021404691,-0.005406155,0.006173003,-0.011831816,0.03372453,-0.0154872015,-0.05919898,0.02604163,0.019875709,0.012928925,0.05541618,0.032848526,-0.08588006,-0.004635301,-0.02855451,-0.10863807,-0.17326446,-0.05520951,-0.025731623,0.043438945,-0.04015716,0.06580579,0.02733902,-0.03407235,-0.05841691,0.043508746,-0.00040063093,-0.003867322,-0.04254601,-0.06477666,-0.0114317825,-0.010648129,-0.018014304,-0.041323487,0.051613074,0.02715415,-0.042482693,-0.04013526,-0.018976668,-0.033184238,0.034367617,0.008238583,0.011104093,0.022729559,-0.016257908,-0.022525553,0.0073329294,0.041806452,-0.069837734,-0.02413106,-0.015318934,-0.034912776,-0.03294647,0.08605857,-0.08138417,-0.0027564657,0.015953531,-0.07568793,-0.09460644,-0.024477707,0.06416868,0.06971473,0.08281365,0.021100398,-0.026571605,0.02147488,-0.022825424,0.030615177,0.061976228,0.001793892,-0.027140211,0.08835689,-0.0037209478,-0.017182063,0.009188332,-0.033221103,0.027904637,-0.009402165,-0.047837675,-0.0011617033,0.041893322,-0.041880634,0.057467513,0.042805493,0.052583795,0.004680495,-0.062221207,0.049852926,0.072753765,-0.0019930154,-0.056399263,-0.024771538,0.027782293,0.038009178,0.13244148,-0.013132569,-0.022542201,-0.019578265,-0.07878432,0.033747084,-0.014154456,-0.03414947,0.103793725,0.016456865,-0.017554035,-0.059813604,-0.0015204898,0.0249934,0.027683198,0.03590038,0.01109627,-0.015324604,0.0035305412,-0.13327865,5.384087e-34,0.077660844,0.063659094,-0.02300184,0.03714132,0.054900452,0.010112553,-0.12618104,0.069542,-0.055192847,-0.03620552,-0.0057512606,-0.04285081,0.028337011,0.051425226,0.01940879,-0.05997252,0.03896429,0.012495712,0.013300307,-0.026635636,-0.035639066,0.055607144,-0.044491753,-0.025074143,0.040996995,-0.034913857,-0.074611336,0.028854547,0.0012635909,0.0026339937,-0.0030980313,-0.084587716,-0.05192036,0.054039605,0.06352756,-0.04403325,0.027978074,-0.027832462,-0.018623963,0.036300197,0.029922068,0.10272811,-0.023603665,-0.07075028,0.0028145919,-0.04477772,-0.023035994,0.046835694,0.041768283,0.0468214,0.036069717,0.013073309,0.11630989,-0.021679292,0.031986464,0.05004286,-0.07874844,0.027114738,0.0012707127,0.045255803,0.035752226,0.10741263,-0.015555366,0.025338002,-0.06858039,0.03061772,-0.12022732,-0.046364333,-0.03386352,0.06170604,-0.012711751,0.057404004,0.07573551,0.049170114,0.048871677,-0.07448618,-0.07684239,0.011935269,-0.004261613,0.036059037,-0.05059032,-2.1910158e-05,0.0044949427,-0.018398857,-0.08446166,-0.011749385,0.032609303,0.017114045,0.034640744,-0.007857207,0.04106867,-0.046022672,-0.060225446,0.020916002,0.033327945,-1.985688e-33,0.09986568,-0.022260265,0.09300532,-0.16702107,-0.091793,0.088958055,0.04435177,-0.015569435,-0.0010738545,-0.03828414,0.08905579,0.033951342,0.04151938,-0.060255013,0.05876645,0.0035212613,-0.0637,-0.026537182,0.010213002,0.004452302,-0.016674243,0.02698441,-0.034874115,0.051976837,0.04449514,0.026188057,-0.030727815,0.07598198,0.014455734,-0.020882418,-0.040079456,-0.0024423494,-0.04959478,-0.018761173,-0.01553597,0.0401194,-0.09635987,0.050572243,-0.03625633,0.061653625,-0.014769021,0.027977724,-0.06081314,-0.030668212,0.06691176,0.05649641,-0.03152273,0.040898554,0.05903091,-0.097670406,0.05722283,0.010479709,0.015353964,0.0006522703,0.042876415,0.044534843,-0.0114288265,0.04508024,0.039715137,-0.042367127,-0.0073044593,-0.027550846,0.013015922,-0.01615698,0.045689788,0.031710632,-0.08264809,-0.03257945,0.055127516,0.014615339,0.06486306,0.028019054,-0.024807692,0.044671506,-0.06416549,-0.09730908,-0.073126264,-0.058871105,-0.0709928,-0.020700108,-0.0031624814,-0.039229974,0.018741695,-0.018402444,-0.023164472,-0.0024393995,0.020103764,0.043123342,-0.019475726,0.033999022,-0.021010345,-0.02098935,-0.076090746,0.15835787,0.035058033,-4.6230152e-08,0.09033292,-0.009488476,0.044947192,-0.062648706,-0.008936831,0.029214801,0.070710056,-0.013890164,0.060590368,0.0016331966,-0.09231484,0.12867354,0.08854974,0.061029553,0.028175395,0.008814355,-0.02983677,0.038976256,0.02852729,-0.008614744,-0.025480384,-0.009973053,-0.08809844,0.05594933,-0.0051606307,-0.066448756,0.04473265,0.005292313,0.035943512,-0.04866231,0.00029912888,-0.008427788,0.090137064,-0.002622658,0.010855395,0.0023261348,-0.08857081,-0.05888828,-0.09332417,0.1271633,0.034011498,-0.05519527,-0.02827021,0.034829028,0.043975566,-0.048008196,0.057609,0.029655397,-0.004058763,-0.022536894,0.011722392,0.046763428,-0.02521873,-0.028556574,-0.077662066,0.027034992,-0.04822391,-0.045950633,0.0060535907,-0.028640099,0.01911764,-0.020674793,0.14586988,-0.032117814 +1.3.1.12,This enzyme in the enteric bacteria also possesses chorismate mutase activity (EC 5.4.99.5 chorismate mutase) and converts chorismate into prephenate.,384,1.0,-0.04210706,-0.07203874,-0.018470947,0.00068873225,0.009967929,-0.015227876,0.005133363,0.020707691,-0.01507607,0.018286576,0.035535745,-0.03982462,-0.012780106,0.018742567,-0.06708126,0.014547023,-0.022641769,-0.000999781,0.007689407,-0.014899836,0.01995492,-0.02218658,-0.007704306,0.013170024,0.03357582,-0.071613826,0.08941611,-0.022666875,-0.092318214,-0.057405666,-0.08740108,0.008174662,0.18423845,-0.042365406,-0.007128077,0.05577307,0.010636887,-0.034849964,0.10449974,-0.014856723,0.06896155,-0.040271513,0.018419828,0.009366747,0.018573137,-0.011181977,0.017264204,-0.028544225,0.034040667,-0.016307177,-0.13054858,0.014508849,0.0022864142,-0.0038881751,-0.0315914,0.0709365,-0.07112641,-0.075749405,-0.0061541046,-0.0629118,-0.013711262,-0.0072043687,0.032016773,-0.027112108,-0.03737712,-0.047768306,0.03962839,-0.035554662,-0.011681085,-0.034244448,-0.0032892711,-0.049690306,-0.027043661,0.031189114,-0.01693981,0.04927546,-0.0105013,-0.022507327,0.03386604,-0.020466626,-0.007352076,-0.008433613,-0.052076444,0.044565037,0.08292986,0.042014614,0.052314777,0.0033957118,0.014394788,-0.0007152269,-0.01885256,-0.018487416,-0.04329131,-0.059472866,-0.083989084,0.0045103375,-0.004925158,0.03140752,0.025453718,-0.026120558,-0.01921231,0.04928148,-0.006239043,-0.08597281,-0.08724398,-0.03364623,0.0505958,0.08507107,0.054722063,-0.0061772,-0.001605085,-0.03296652,0.08307429,-5.4213906e-05,-0.0687106,0.1485696,-0.0063862437,-0.043954756,0.05230742,0.08755309,0.01480456,-0.01682405,0.01037323,0.052630797,-0.074986674,-0.056418743,0.0069295894,2.8821307e-33,0.014688492,-0.012669269,0.015623445,-0.007449975,-0.031928677,-0.027663643,-0.08194978,-0.028987477,-0.0415469,-0.08009736,-0.026142184,-0.071706645,0.0043161605,0.07251349,-0.015863739,0.042761236,0.056227334,-0.007179315,0.037110403,0.038074274,-0.0057645007,0.015386575,-0.06527397,-0.0009317166,0.12740329,0.00051662145,-0.01704269,-0.031891096,0.06278356,0.0075996057,0.06668414,-0.048306704,-0.023717957,0.023071572,-0.019394854,0.095691346,-0.055092745,-0.0060075703,-0.079554334,0.04353487,0.0054334966,0.016145077,0.022625545,0.006086533,0.016593188,-0.066662036,-0.07885953,0.10424272,0.08810336,0.07014871,0.034402635,-0.0017099999,0.071779326,0.0014287417,-0.056474827,0.02258307,0.0471007,-0.01163889,0.0081741605,0.044257663,-0.009702654,0.015208512,-0.08737474,0.038595308,-0.02112236,0.033932578,-0.08176854,-0.06829668,0.03013518,0.08254917,-0.14974992,-0.0791471,-0.089166194,0.08645651,-0.028569112,-0.042868756,-0.0590292,-0.04501141,0.042956755,-0.04249238,-0.04007975,-0.036776923,0.0010768046,0.033292416,-0.040793538,0.02617004,-0.04077803,0.03137352,0.055406634,0.025858203,0.10419743,-0.06357217,-0.10761448,0.061897386,-0.047741078,-3.7237637e-33,0.051281646,-0.0838229,0.04262106,-0.004651948,-0.08167958,0.12041422,0.035569638,-0.03568792,0.06396187,-0.026218666,0.107754305,-0.025243828,0.012531233,-0.092560135,0.017852873,0.050552335,0.07992769,0.07188172,-0.04161901,-0.00277724,-0.021749688,0.063885,0.06578987,-0.016113171,0.027697422,0.032952175,-0.013680403,0.11168988,-0.01668224,0.06290037,-0.071138665,0.00978007,-0.0323325,-0.019154081,-0.050409887,-0.00070054835,0.010960264,-0.02521325,-0.011215141,-0.02796839,-0.019119538,0.043020576,0.023869375,0.11515159,-0.012261042,0.081569925,-0.020445568,0.06408662,-0.0023120996,-0.011365004,0.035459302,-0.0071422225,0.03939832,-0.06678603,0.06041321,0.043166753,-0.032499913,-0.040414825,-0.02359949,-0.1119824,-0.053014074,0.0019833192,0.09486587,0.00018991815,0.03897387,0.028533004,-0.061368912,0.050636556,-0.007819361,-0.093313485,0.020517591,0.04447863,-0.01537533,0.042269815,-0.014031167,-0.01994492,-0.08666244,-0.016823413,0.05360992,0.0052838395,-0.009865575,-0.028913189,-0.0055528074,-0.00853521,0.027735034,-0.0054439264,-0.011405928,0.06438163,0.03548341,0.07337042,-0.058039892,0.026095146,-0.05997152,-0.017722335,0.029752359,-3.1428474e-08,0.063986376,-0.10046507,-0.028651671,-0.022153873,-0.016558459,0.009905532,-0.021187758,-0.0082949875,0.074268505,-0.026076436,-0.07054451,0.13116865,0.023784956,-0.055875994,-0.044196274,0.07686134,-0.0003700873,0.0008491621,-0.044505287,0.02522978,-0.047251083,-0.014683113,-0.09602108,0.06378751,0.082176894,-0.0043763327,-0.017830959,0.102945276,-0.027281782,-0.034588736,0.014966153,-0.027378913,0.03901477,0.012855673,-0.044562984,0.02744304,0.00701709,-0.03334945,-0.016972193,0.058429416,0.07053339,-0.0411568,-0.08313059,-0.044821918,-0.028911855,0.004736167,-0.04624901,0.03894421,-0.027305096,-0.05186191,-0.00407398,0.014712867,0.031658813,-0.0025123549,-0.08772734,-0.0069557843,0.072668165,-0.07962401,-0.00936439,-0.014679136,0.0028317901,0.05971576,0.20294443,-0.012306299 +1.3.1.14,"Binds FMN, FAD and a [2Fe-2S] cluster. The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit [4]. The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.",384,1.0,-0.07847918,-0.044166174,-0.09374484,-0.101815306,0.06942665,-0.051376086,-0.0773476,0.08113788,-0.0023287344,-0.06463819,0.03399868,-0.031145126,-0.15760033,-0.0051149265,-0.04052117,0.013411189,-0.09305284,-0.05608307,0.008757343,-0.038057063,0.019505732,0.003945461,-0.00975515,-0.07088828,-0.06396845,0.044443153,0.04279204,0.054912183,-0.01982913,-0.039252304,-0.016962983,-0.038780548,-0.010712573,0.029513985,-0.059328943,0.112485014,0.04370933,-0.020465814,0.004852614,0.041471668,0.0037001062,0.0056502344,-0.012792353,-0.016958386,-0.009879185,-0.019185916,0.021932421,0.0650095,-0.01171434,0.004486738,-0.018982364,0.022549566,-0.004645919,0.047469817,0.043804824,0.04947609,0.023240756,0.027874265,-0.097124115,0.04811006,0.0049695536,-0.023367355,-0.035555203,0.0035267281,0.048231315,-0.02220874,0.06858727,-0.09472478,0.01498417,-0.026876189,-0.059048373,-0.03864623,0.004933085,-0.032614253,0.00047499928,0.08712887,-0.03239632,0.012135551,0.040150244,-0.052832454,-0.0023360674,-0.043479305,0.09074222,0.053278696,0.05106885,-0.029274601,-0.04386338,-0.03839526,0.015832672,0.09122907,-0.0006878628,0.024303816,-0.016589511,-0.015943909,-0.093388274,0.11781347,0.023290003,0.09283179,0.000303193,-0.011580698,-0.009191032,0.062854685,-0.07713647,-0.03423118,-0.058341403,-0.042576503,0.02253852,0.047708675,-0.054382473,-0.024894224,0.028485984,0.021251602,0.050956726,0.0014198886,-0.01975855,0.05394099,0.03743885,-0.035487212,0.03270443,0.008088514,-0.026448367,-0.000944127,0.0009791636,0.09761052,0.016539564,-0.019578058,-0.21076466,2.5490845e-33,0.035576753,0.06208379,-0.022228101,0.0018810349,-0.016105708,-0.00040097343,-0.07642539,0.026438778,-0.092082344,0.009189795,-0.029489886,-0.047131106,0.08859842,-0.037635367,-0.02429929,-0.081500985,-0.020433022,-0.0061567007,0.031339455,-0.04669376,0.07903785,0.05838424,0.039750427,-0.034457993,0.052071083,0.06750864,-0.07622149,0.067578666,0.06358902,0.0077206995,0.028589383,-0.15172422,-0.016448988,-0.0005872556,0.010762787,-0.05150436,-0.06504889,-0.02238076,-0.045571856,-0.040184345,0.0055609266,0.040071685,0.0006333555,-0.023468466,0.05831819,-0.060168978,-0.017715285,0.04871254,0.01701615,0.028444735,0.018482953,-0.06241779,0.07139803,-0.06708875,-0.025461113,-0.04231762,-0.01298805,0.032986257,0.03952124,0.122312255,0.015300539,0.07784429,-0.02903958,0.051153228,0.070164174,0.013447212,-0.036887236,-0.07702352,0.0588354,0.09552892,0.00602107,-0.016463997,0.12069444,0.0078522535,0.051858462,-0.04191686,0.0016874579,0.004997315,-0.0067739496,0.006257189,0.024209758,-0.037813365,-0.01724439,-0.020323731,-0.09736381,-0.041695133,-0.020269625,-0.047683906,0.028789895,0.019418268,0.031383827,-0.061384108,-0.0022059504,-0.047036476,0.06505968,-2.8470413e-33,0.028713424,-0.009809509,0.031368937,-0.084931254,-0.01732752,0.13960561,0.031886693,-0.059603028,0.051422957,-0.011385895,0.09457265,0.013836179,0.012900478,-0.05509515,-0.041773535,0.010672928,-0.041558977,-0.019629868,0.026882755,0.007328205,0.02425953,0.091235094,0.0543266,0.14603412,0.00508805,-0.016741972,0.029130556,0.044408485,0.020073116,0.019031744,-0.07556676,0.040286385,-0.046618078,0.0067917653,-0.004578446,-0.025974376,-0.06299896,0.009518106,0.014367467,0.040275373,-0.006225062,0.010579138,-0.0029914666,0.075399004,-0.030411415,0.08581832,-0.05727507,0.017893896,0.008819041,-0.03237911,-0.009927207,0.010104288,-0.066575356,0.056676686,0.0849926,0.03936072,0.015570765,0.0039754226,0.0074315188,0.034238294,-0.0050085643,-0.11353569,0.033586252,0.006468935,0.013481882,-0.020735916,-0.050927304,0.1332579,0.0019418839,0.091754965,0.052017193,0.045638394,0.07480416,0.0059935013,-0.051599257,-0.015086414,0.012934165,0.01994811,-0.0007864794,0.038232982,0.017631153,0.013665847,-0.04733707,-0.0054078535,0.04540434,-0.04892703,0.09027241,0.09866014,-0.020169472,-0.03907647,0.050573,0.020052206,-0.014729295,0.040335134,0.023038892,-4.0379703e-08,0.021237053,-0.094205715,0.084777154,-0.041199762,0.018318465,0.05377525,-0.004997046,0.032149214,-0.033174016,0.030379599,-0.025047531,0.10367183,0.0053257085,-0.03416239,0.037327975,0.029359508,-0.04404843,0.03033466,-0.024698528,-0.010272626,-0.033578925,-0.013752592,-0.13132031,-0.001536896,0.038181834,-0.08553318,-0.030631322,-0.060175203,0.020096572,-0.016182868,-0.023011018,0.0059510544,0.027253123,-0.037428062,-0.06004577,-0.028914126,-0.056153126,0.01019558,-0.108410105,0.039910857,0.04388165,-0.057421897,-0.023272365,0.0187429,-0.016020393,0.06956143,-0.008845086,0.008961438,-0.016322358,0.04354059,0.07734528,0.019471554,0.048980605,-0.078440264,-0.11938815,0.006704069,-0.076350935,-0.07380262,-0.03099708,-0.0225346,0.025124352,0.037430227,0.11778589,0.017537901 +1.3.1.15,Binds FMN and FAD [2]. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor .,384,1.0,-0.09097555,-0.025695661,-0.08005609,-0.12489953,0.01208309,-0.037880566,-0.04482226,0.07447457,0.015842462,-0.039314304,0.043588813,-0.045961484,-0.16070516,0.019154483,-0.030922499,0.009523938,-0.057259228,-0.054961503,-0.014995068,0.011022092,0.02983693,0.021269487,-0.031450838,-0.07129619,-0.030214436,0.014667598,0.017857265,0.062053405,0.013098067,-0.046523817,-0.01152305,0.011182503,-0.02497667,0.06264458,-0.116750985,0.075176835,0.03121015,-0.04020506,0.020988641,0.09019324,0.0060606385,-0.007781977,-0.0047838343,-0.023245884,-0.013984066,-0.029453592,0.017318003,0.088688776,-0.007629765,0.011065815,-0.008140172,0.007854711,0.02797249,0.06597992,0.0072023054,0.011678494,0.042769976,0.037993453,-0.110238224,0.060643658,-0.021201698,-0.023255432,-0.041104734,0.008770042,-0.0025182571,-0.045339707,0.06171071,-0.063140556,0.016391167,-0.016465742,-0.05477992,-0.06744161,0.022944229,-0.04073589,-0.016770933,0.12432728,-0.04941356,-0.002828689,0.039105095,-0.08032365,0.0024066994,-0.006467553,0.05673324,0.053984705,0.07993414,0.008453072,-0.051342297,-0.017454538,-0.020999778,0.06426083,0.019955138,-0.0058277743,-0.013735552,-0.012284654,-0.08108665,0.11530244,0.04504459,0.058984015,-0.013403238,-0.019117218,-0.03201518,0.06816092,-0.06451974,0.010204245,-0.064319886,-0.016796222,0.026094366,0.041233316,-0.10512264,-0.049623076,0.006928708,-0.045980763,0.04874101,-0.00042872754,-0.023619698,0.021264281,0.009824429,-0.058874823,0.05203585,-0.035589885,-0.082728505,-0.038415994,0.0055771777,0.07700512,0.03834466,0.021347383,-0.14812532,3.204013e-33,0.06165428,0.02473051,-0.04707586,-0.026812084,-0.03376472,0.0076133967,-0.07398333,0.017173141,-0.07743591,-0.021174606,-0.014188664,-0.01647425,0.07522319,-0.026332391,-0.010440942,-0.016643966,-0.010514936,-0.032731824,0.02175957,-0.032068044,0.09341001,0.06579072,0.025396202,-0.05647031,0.042058136,0.05235863,-0.06517518,0.0873816,0.05484311,0.008127352,0.03962419,-0.13299349,0.010300397,-0.010352065,-0.026485093,-0.025240304,-0.09480534,-0.0035366002,-0.050405487,-0.056574907,0.025044668,0.06663051,-0.00800219,-0.02525527,0.043947037,-0.038333822,0.00493016,0.042004738,0.0024074535,0.0076512387,0.035081327,-0.034355134,0.032707736,-0.09180318,-0.008395629,-0.029894155,-0.00762819,0.06774668,0.02560619,0.11107156,-0.025371237,0.060284488,-0.03668471,0.053983614,0.05163547,0.0029942915,-0.04909251,-0.1158754,0.02983558,0.05144489,0.009345837,-0.028359022,0.11530332,0.013979527,0.06758213,-0.018318031,0.008275934,-0.02775716,-0.018762449,-0.018102888,0.043374293,-0.041093297,-0.010033793,-0.008495864,-0.12120388,-0.02228597,-0.00920431,-0.020285597,0.0574184,-0.002791745,0.012840477,-0.069569044,0.011586316,-0.031663537,0.086245716,-3.3115656e-33,0.024892807,0.016404876,0.0281894,-0.04858912,0.00825291,0.21332397,0.020250598,-0.088788554,0.05827621,-0.020018835,0.09648862,0.0311732,0.006013308,-0.05581843,0.007192614,-0.0023712849,-0.09364349,-0.05839637,-0.008618552,0.0167263,0.029368708,0.08701946,0.07260578,0.10250306,0.013467496,-0.025422826,-0.01239464,0.04141644,-0.007339372,-0.003228234,-0.09025504,0.03890369,-0.014065505,-0.013839408,-0.018644456,-0.029764237,-0.042227283,0.036151573,-0.0017159574,0.052756444,-0.031122724,-0.0065952316,0.018762656,0.07074758,-0.022589881,0.08774249,-0.07714832,0.0073196567,0.033691153,-0.004445101,-0.016610125,0.025118189,-0.05505892,0.040114786,0.09597198,0.06858765,0.052508723,0.007921116,0.0005391176,0.023899373,-0.016643854,-0.09721194,0.05376571,-0.01816858,-0.02327725,-0.013504269,-0.048404224,0.1277071,0.03415146,0.0662676,0.060389616,0.05508973,0.0670883,0.017763935,-0.007632155,-0.0018372741,0.0029060857,0.00073671143,-0.01930124,0.056634218,0.006107307,0.03688409,-0.09180067,0.009599997,0.060240965,-0.000331866,0.081691176,0.032419052,-0.027847407,-0.02033155,0.07044714,0.037686173,-0.015221074,0.019561965,0.028621148,-3.5986112e-08,0.03468862,-0.077447526,0.095343456,-0.04312882,0.018491415,0.0048727896,0.009793569,0.043147646,-0.019498494,0.03987915,-0.002356515,0.09806399,0.022285588,0.007633202,0.06800622,0.00069515605,-0.026852852,0.0018861671,-0.049495574,-0.0011199373,-0.01087751,-0.037238304,-0.08320221,-0.014801187,0.025080666,-0.056118328,-0.01675181,-0.068300925,0.0011246352,0.050534934,-0.0072334423,0.016347824,0.026714118,-0.044553407,-0.03398135,0.010635321,-0.013988959,0.0034392253,-0.14072873,0.06954736,0.07432821,-0.08375956,-0.05587964,0.0062464927,0.023814877,0.06700883,0.009137669,0.006067067,-0.013160999,0.046589363,0.048269235,-0.006106994,0.04807011,-0.08264345,-0.110325485,0.009593309,-0.077948235,-0.085031286,-0.011847571,-0.03237942,0.032512985,0.0076755066,0.11861594,0.013502746 +1.3.1.21,The enzyme is part of the cholesterol biosynthesis pathway.,384,1.0,-0.05683963,-0.029335033,-0.11436289,-0.007645467,-0.01003218,0.029610517,-0.120162904,0.021337755,0.032588754,-0.047751095,0.013748558,-0.014381282,-0.063720874,-0.04334036,0.013452888,0.050176006,-0.110511556,-0.023202304,0.016857764,-0.0535023,0.061780114,0.04227633,-0.043582894,-0.0054032966,0.00015490648,0.021607025,0.0876016,-0.07630952,-0.030555982,-0.033484817,0.01136195,-0.036124624,0.03275834,-0.06144651,-0.0044148425,0.07661232,0.010145947,-0.019957006,0.034452528,-0.028087374,0.07615766,-0.014646534,-0.030062264,-0.019079512,-0.008684075,-0.036790956,-0.0015728935,0.014095132,0.011428352,0.06395413,-0.083489984,-0.060779035,-0.054532617,-0.049207717,0.03848106,0.09187136,-0.008378182,-0.047450554,-0.023165282,0.014317379,0.016875401,-0.035886347,0.00051153055,0.038127016,-0.040640935,-0.11010588,0.03079863,-0.016276056,0.004695658,-0.07396342,-0.050315164,-0.092976905,-0.083871745,0.020208642,0.022583038,0.030373065,-0.048088066,-0.03968424,0.056454267,-0.03551546,0.06814831,-0.05416675,-0.016793653,0.12143607,0.09419736,0.027913066,0.03955033,0.027355991,0.0028710878,0.019117588,0.015005337,-0.09034087,-0.007199393,0.025603289,-0.03368564,-0.013688287,0.055342484,0.00038667035,-0.0068585547,-0.03938857,0.038741987,0.018465018,0.007534126,-0.0487873,-0.065724865,-0.030634651,0.012933523,0.05985087,-0.032467525,0.016576441,0.0109402295,-0.005107236,0.06742485,0.0022384017,0.0030036592,0.101814605,-0.03086223,-0.0558778,-0.025576338,0.0666665,0.031601496,0.058145873,-0.0067258817,0.09190706,-0.02317613,-0.007447872,-0.06577215,-2.5365227e-33,0.045323353,-0.0020321982,0.018240163,-0.046073887,-0.004437865,0.02250189,-0.036391657,-0.013274314,-0.0095702605,-0.026984515,-0.008473694,-0.11782972,0.017499028,0.031105988,-0.028276136,-0.002078728,0.0076365164,0.047410645,0.051372945,0.019921143,-0.055080462,0.07921647,-0.09727401,0.028426073,-0.018186983,0.016958637,-0.027527396,0.039804842,0.0094471155,0.011119357,-0.026448403,-0.09547404,-0.10152727,0.004891451,0.09192312,0.031907763,-0.029981539,-0.05127835,-0.061706197,0.08407628,0.014885358,-0.021563174,-0.033073273,-0.023499558,0.015767924,0.02056597,-0.043173887,0.022782052,0.06332022,0.044035483,-0.012616882,-0.0075212815,0.14502819,0.023965387,-0.00082495675,0.059262615,-0.025087621,0.034634795,-0.007940126,-0.015651865,0.0009760017,0.07638842,-0.08461655,0.05946823,-0.00923081,0.026588274,-0.051831897,-0.03336945,-0.05566233,0.1579612,0.010846132,0.013333134,0.0072538718,0.008146071,0.038722523,0.0143305,-0.041990697,0.056466248,-0.03731646,-0.03154792,-0.019567136,0.022965264,-0.015831733,-0.083180636,-0.044518504,0.046785925,-0.024449958,-0.026637098,-0.038018856,0.030437304,0.034616135,-0.02969607,-0.09614323,0.05286742,-0.027877105,-8.214503e-34,0.023587745,-0.101941615,0.063469075,-0.08006684,-0.049237728,0.07772923,0.018458076,-0.031497326,0.09845022,-0.006155474,-0.020554747,0.019324912,0.03243766,-0.07946481,0.054821223,0.08450904,-0.025450379,0.035695013,0.0051994207,-0.02653253,-0.022552066,0.092400126,0.0393508,0.121740445,0.022644017,-0.010669362,0.009287217,0.043344982,0.060100973,0.057861168,-0.017095387,-0.085624486,-0.07413823,-0.039992098,-0.097740404,0.07361424,-0.06345914,0.022097198,0.024190657,0.027300572,-0.048404206,0.029917667,0.04083605,0.022865538,0.0007501803,0.021694763,-0.010645287,0.07428704,-0.009615869,-0.10459653,-0.02737124,0.042868923,0.060711555,0.06844431,0.02253015,0.0653954,0.039667975,0.022469861,0.046500426,-0.09508033,-0.06407245,-0.01518133,-0.0021821249,-0.029284267,0.011335665,0.059278037,-0.021538662,-0.015742624,0.018519731,-0.013116193,0.037834857,0.104620405,-0.010866064,0.090539835,0.006625618,-0.0092296675,-0.12054867,-0.052752413,-0.028188227,-0.057801627,-0.02484728,0.011838443,0.036931902,-0.09930782,-0.07879514,-0.09071753,-0.0151662715,0.06049394,0.08734071,0.013130493,0.001938076,-0.0040403213,-0.10533037,0.06629495,0.0045866203,-2.2193861e-08,0.055803314,-0.07805925,0.041523166,-0.04523417,-0.045144435,0.014652054,0.03879396,0.03694394,0.053297292,0.01893145,-0.029201806,0.12592864,-0.0020499176,0.010714659,0.013012242,0.043492515,0.009815505,0.01938212,-0.0053037736,-0.0034677787,-0.008996841,-0.03129017,-0.066854015,0.033769127,0.033318613,-0.03266909,0.0031429464,0.03683817,0.011390051,-0.048817523,-0.0047953753,-0.023030527,-8.339648e-05,-0.03413042,-0.055309962,0.04173683,0.011724539,-0.061949287,0.012406072,0.08085678,0.027722703,-0.04290209,-0.008968535,0.020969784,-0.033963747,0.0072147567,-0.006136484,0.039107285,0.009963404,-0.017432619,-0.077072226,0.023995087,-0.032327075,-0.012352562,-0.07422981,-0.018351417,-0.019241191,-0.09958227,-0.005829235,-0.035190564,0.0123328455,0.09109445,0.27455115,-0.008989852 +1.3.1.22,"The enzyme catalyses the conversion of assorted 3-oxo-Delta4 steroids into their corresponding 5alpha form. Substrates for the mammalian enzyme include testosterone, progesterone, and corticosterone. Substrates for the plant enzyme are brassinosteroids such as campest-4-en-3-one and (22alpha)-hydroxy-campest-4-en-3-one. cf. EC 1.3.99.5, 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor).",384,1.0,-0.015317859,-0.009154113,-0.06408656,-0.05484754,0.013869838,0.07096751,-0.08572255,-0.028393973,-0.041524176,0.03492663,0.042437527,-0.043905362,-0.120251186,-0.04592407,0.057680894,0.027015958,-0.074941725,0.048599686,0.044398617,-0.0953555,0.04699217,-0.0375051,-0.07176255,-0.05604691,0.051521912,0.0046861353,-0.018305697,-0.0028567647,-0.017236467,-0.07595524,-0.00419734,0.0026249324,0.025113093,-0.0482166,-0.07101726,0.013149614,-0.083423845,-0.08696442,0.105611674,0.095628634,0.08839889,-0.014766903,-0.03773893,0.014790727,-0.06490536,-0.01735633,0.004411138,0.020735964,0.053678576,-0.054899123,0.015352472,-0.09503519,-0.019053798,0.037404533,-0.09071223,-0.06486186,0.019337758,0.043486055,-0.011077416,0.09413728,0.013219232,0.024649305,-0.062807426,0.026514146,0.013735722,-0.0031320073,-0.080191106,-0.046503708,-0.0332594,-0.002179833,0.017915325,-0.035778075,-0.06446626,0.03139271,-0.0639846,0.06714232,-0.01197672,-0.032687966,0.08030098,-0.027638061,-0.010465875,0.03702042,0.008902636,0.05315174,0.033719778,0.042589072,-0.0575959,0.030309374,0.014523736,0.061026655,0.009725183,-0.0056490526,-0.041999202,0.008163331,-0.04358663,0.12882218,0.009743056,0.006669262,0.030845031,-0.029860195,0.03979724,0.029077135,-0.0673807,-0.063663475,-0.06644764,0.09117258,-0.012612227,-0.00018010393,-0.049154222,-0.0002999353,-0.03102088,-0.013523557,0.0025229477,0.03319488,-0.020813858,0.020256806,0.010176055,-0.059192255,-0.04990884,-0.085804,-0.009371294,-0.007139469,0.050644603,0.036071215,-0.017882785,0.029489148,-0.06063696,-1.6788252e-34,0.05323614,0.0057130307,0.0050424705,0.017039066,-0.013145767,0.034331523,0.01802531,-0.026243553,-0.049674965,-0.014941954,-0.061798945,0.003008353,0.0011841615,0.018165361,0.0122642955,-0.0439123,0.033975128,0.06040914,0.09016956,0.04219993,-0.006655426,0.037745167,-0.116513714,-0.0086749615,-0.0013543406,0.09329253,-0.028891966,-0.032562364,-0.015697416,-0.004054046,-0.07393717,-0.052779756,0.013354274,-0.0324939,0.02731016,-0.05854141,-0.011340924,0.0031211637,-0.06767217,0.043436803,0.06642232,-0.0075136824,-0.015263133,0.038625244,-0.0071463087,0.011334559,-0.0765502,0.022894917,0.117782705,0.064288914,-0.013037785,0.019128425,0.11458779,-0.010693154,-0.018377075,0.078365825,-0.05257875,0.031324293,0.021482227,0.0027739103,-0.00013386487,0.08334108,-0.035797503,0.050983313,0.005992139,0.009268443,-0.052010894,-0.11995454,-0.02030983,0.10939317,-0.017843755,-0.049223006,0.028090736,-0.014788052,0.0897145,0.029766733,0.040347695,0.042536944,0.0066609173,-0.050967805,0.013238929,0.0024457744,-0.011843095,0.003802603,-0.027158024,3.8790255e-05,-0.009333067,-0.02910244,0.04500555,0.049492728,0.10481369,-0.064647615,-0.040433213,-0.004282234,-0.006481515,-1.1380441e-33,0.069485515,-0.047254346,0.042750016,-0.12885399,-0.056094892,0.10687118,0.055093996,-0.06478961,0.042520676,0.10146446,0.0014591933,0.011971253,-0.007683509,-0.06222665,0.019625243,-0.050387517,-0.0007806197,0.07628393,-0.05778034,-0.052005775,0.0019101221,0.16919845,0.00015120064,0.07681687,0.049884707,-0.008061238,0.037647165,0.04877662,0.033692256,0.020043362,-0.021052089,-0.020121833,0.058895927,0.0075104334,0.0031829292,0.028156742,-0.0039682626,0.059307188,0.014175517,0.028975254,-0.054515466,0.042493526,0.0105404435,0.07862202,0.009971691,-0.021600092,-0.078307,0.06187668,-0.025820024,0.05011075,0.0068588965,-0.03368008,-0.07424788,-0.037580863,0.022828404,-0.017632818,0.016888874,-0.053873118,0.030000877,-0.03434388,-0.030265506,-0.06061588,0.036484588,0.052922413,0.022548402,0.0659327,0.029126797,0.0047369995,-0.060315188,0.05001422,0.053666137,-0.00614077,0.029254401,0.07449018,0.0318161,-0.023135528,-0.052510552,-0.011878246,-0.049587246,0.029185262,-0.04354003,0.0017256555,-0.012877269,-0.05006426,-0.018970033,-0.047338285,-0.0035988046,0.14035647,0.08355709,0.0697895,-0.008368395,-0.040033188,-0.08728907,0.06733551,0.08494505,-4.215036e-08,0.019753007,-0.0035107243,0.063453145,-0.036622014,-0.124946944,-0.0052371426,0.029937977,-0.029488966,0.13991484,-0.046602312,0.0013395083,0.067286536,0.052125648,0.046307724,0.072370835,-0.0040486087,0.014929444,0.03711661,-0.016344694,-0.016927762,-0.060556434,-0.012009747,-0.07185613,-0.0029356547,0.017332248,-0.041642953,-0.0174939,0.09753593,0.007839917,-0.0077622468,0.05392272,0.039711505,-0.0072916374,-0.047460794,-0.04775801,0.025652727,0.0047160923,-0.025975741,-0.011424976,0.046999168,-0.0872084,-0.0984687,-0.012729946,0.031191831,-0.0140439775,0.0014155044,-0.004213905,0.039912917,0.07259269,-0.0134166805,-0.06812449,0.0015161736,-0.052331723,-0.100908026,-0.08160276,-0.035705697,-0.031910427,-0.032226324,-0.022842795,-0.08756674,-0.0038053256,0.046468314,0.21368891,-0.001996793 +1.3.1.27,"Specific for long chain 2-trans- and 2-cis-alkenals, with chain length optimum around 14 to 16 carbon atoms.",384,0.99999994,0.053737406,0.01014242,-0.013363563,-0.01936275,0.01009674,-0.015110745,-0.0821768,0.14425279,0.02129067,-0.045779463,0.01409195,-0.01038891,-0.03736057,-0.057657663,0.009904123,0.061807558,0.015133877,0.015184454,0.020183604,-0.026394794,0.03904672,-0.048866466,0.035233013,0.0070535294,-0.10221911,-0.07162739,0.0012725871,-0.02347214,0.045740426,-0.03902933,0.02832201,-0.023873666,-0.019119222,-0.020666989,-0.023182524,-0.058770046,-0.015513744,-0.015758198,0.048843488,0.009743377,0.021195726,0.044018067,0.06609014,-0.0025519482,0.008960581,-0.05346364,-0.058163248,0.028033214,-0.035118997,-0.007684193,0.06994138,0.006487216,-0.06657965,0.14946556,0.07914174,0.050280035,-0.12921031,0.014536334,0.012580805,0.040284403,0.09629185,-0.053199053,-0.04250571,-0.044091906,-0.011559205,0.032502282,0.017841741,-0.04840485,-0.030383242,0.07729538,-0.084036194,-0.02851078,-0.08489988,0.06758588,0.068534344,0.022830276,0.0013683586,-0.029400358,-0.04117174,-0.09517278,-0.046072405,0.034501843,0.09094275,-0.048777565,0.02248212,0.063283525,0.01723757,-0.018624136,0.005812144,0.035829708,-0.005505227,-0.03191196,0.04844986,-0.086568885,-0.0015000765,0.047079638,0.07802272,0.045482557,0.01662361,0.0035504047,0.11718408,-0.033029355,-0.08590927,-0.06796054,-0.11086897,0.040094495,-0.034167964,0.037639435,0.0046572764,0.020443177,0.026737517,0.05306463,0.014986985,-0.106116906,-0.036887493,0.016459417,0.01074596,0.014021184,0.10088643,0.08135087,-0.01743236,0.01393555,-0.011885208,0.043173075,-0.11383438,0.021478986,-0.012441343,-5.826215e-34,-0.042509645,0.06304578,0.05817434,0.057355795,0.0034726763,-0.018476242,-0.08464013,-0.08227575,-0.07092158,0.014746739,-0.05677128,-0.047009747,-0.002444056,-0.031525638,0.05672072,-0.096643634,0.027808297,0.054317463,0.06219971,-0.081023544,-0.046418957,0.03216307,0.041544974,0.058040973,0.09228507,-0.0650685,0.03599819,-0.03798063,-0.035259165,-0.025638077,-0.032822214,0.033867955,-0.028788099,0.039281856,0.03188977,-0.017291702,-0.02396756,-0.007034782,0.049310938,-0.039846145,0.10352148,0.014172232,0.08209059,0.023893636,0.023504136,-0.007661511,0.007525579,0.0040648347,0.01597362,0.07752714,-0.027059736,0.052848723,-0.08702172,0.007741032,-0.029672856,0.016588164,0.01286639,0.0072680875,0.04566953,0.062243152,-0.078137584,0.0785545,-0.017421477,-0.007955176,-0.021792661,0.102706544,-0.11512998,-0.02007364,-0.04701837,-0.0063924645,-0.0006453356,-0.0023368027,0.14739615,-0.007051673,0.05558667,-0.021992553,-0.14883259,-0.050791733,0.0096400995,0.08029078,-0.081352055,0.027058093,-0.06205152,-0.010091495,-0.04909737,-0.10366832,-0.031733878,-0.004657382,0.010281686,0.104433514,0.01299773,-0.038088925,0.025175171,0.056213118,-0.01990255,-7.568045e-34,0.05480311,-0.08089557,0.061774876,-0.010612111,0.060684048,-0.05319918,-0.015944302,-0.027345791,-0.0073307343,-0.0041814116,0.16846445,0.029144472,-0.019822516,-0.004154381,-0.024928859,0.010484228,-0.016199986,-0.00064005953,0.08267557,-0.015310991,0.1128465,-0.07821331,-0.070959695,0.115865126,0.02018087,0.022923626,0.11215442,-0.03854362,0.08129041,0.007103631,-0.037165128,0.009022621,0.02985801,0.07833399,-0.09006061,-0.010351062,0.007403145,0.09271843,-0.04489888,0.06063614,-0.019495329,-0.011797504,-0.009785371,0.01812388,-0.007634663,0.03669454,-0.017121002,-0.054158136,-0.011475425,-0.05571681,0.013849113,-0.037949327,-0.010436013,-0.022730332,0.0016455742,-0.024798794,-0.13627505,0.05511189,0.10132967,0.0016976622,-0.021784248,0.027262654,0.029391889,-0.031862866,0.011212147,-0.04322293,-0.05342191,-0.052241676,-0.0070164986,-0.023079192,0.029447947,0.0222632,0.018274762,-0.00514476,-0.047521554,-0.10821958,0.090585135,-0.09392967,-0.000102899685,-0.0019037205,-0.056722887,-0.043039605,0.0104429275,0.03564178,-0.015881568,-0.016731618,0.05733117,0.06806572,-0.019759478,0.01982422,-0.0080935145,0.004344305,0.035478525,-0.055211205,0.013531695,-2.3803572e-08,0.035372343,-0.06098044,-0.027756784,-0.031928353,-0.0006362424,0.03302357,0.040603876,0.043359395,-0.020139677,-0.0466453,0.01545072,0.064122334,0.035415202,0.022724014,0.019963328,-0.059393577,-0.043308377,-0.018989887,0.027729431,-0.016977532,-0.055773318,0.03252853,-0.01971478,-0.026394418,-0.08286999,-0.059494816,0.07159576,0.030629983,0.009478966,0.026846314,0.020509003,0.018456843,-0.035585716,0.006574953,0.05952336,-0.033625957,-0.0670302,0.0069577713,0.0008756618,0.05963211,0.025929881,0.03449231,-0.009698777,0.009017975,-0.011823587,-0.037980754,-0.059017286,0.03872299,-0.021212745,0.03997705,0.05935264,0.0014934655,-0.032640126,-0.024443077,-0.015119628,-0.010622769,-0.045098647,-0.009938303,-0.096142784,-0.090706244,0.055844992,-0.012962334,0.05589119,-0.037592262 +1.3.1.29,"Also acts, at half the rate, on cis-anthracene dihydrodiol and cis-phenanthrene dihydrodiol.",384,0.99999994,-0.044899393,-0.08940043,0.014313372,-0.0039205304,0.103191644,-0.06262842,-0.047907498,0.05483925,0.097656846,-0.0050871,0.015989203,-0.024731552,-0.03151469,0.06913753,0.0045164865,0.033055414,-0.08264467,0.009213019,0.0038918718,-0.0010121184,0.008911203,-0.019046782,0.0063449284,0.038801562,-0.047824748,0.031696737,-0.013224739,0.047048006,-0.012255313,-0.037107725,0.062772386,0.02823554,-0.028721273,-0.008849514,-0.030341597,0.11652069,-0.089619145,-0.010748594,0.053533275,0.0060048793,0.053903725,-0.06358515,0.023872027,0.0059991647,-0.053396415,-0.0029356638,-0.040176947,-0.03201284,-0.027566547,0.01355333,-0.022629833,0.012992945,-0.06384649,0.054317813,-0.058492932,0.0038771702,-0.07863281,0.04799807,-0.015010606,-0.018149512,-0.017895525,0.0025523547,-0.022527274,-0.012415473,-0.053152237,0.00058033987,0.044397514,-0.07539734,0.012312788,0.0014324575,-0.062212136,0.022198433,-0.0073994654,-0.03506129,0.07454164,-0.044878323,-0.037508,-0.06506879,-0.018056063,-0.10637716,-0.015766082,0.021442143,0.03327289,-0.056281593,0.013075246,0.048785318,0.030199846,0.038572297,0.029740693,0.024090363,0.020858072,0.11377737,-0.01067065,-0.008752919,-0.050117306,0.02612411,0.035823707,0.041022178,0.026190443,-0.0030677759,-0.066866115,0.0140866935,-0.18434617,-0.0678564,-0.106008746,-0.038843688,-0.02179014,0.059219465,-0.10295844,0.069229834,-0.019996544,-0.005241427,0.0547793,0.023978293,0.028638678,0.050995998,0.0070319725,-0.025161082,-0.044324014,-0.073508345,-0.06101413,-0.060898352,-0.016914554,0.06852357,-0.07623842,0.04139913,0.032117687,2.491709e-33,0.04999093,0.015674308,0.024554476,-0.032906633,-0.020454355,-0.017751463,-0.11519999,0.017178815,-0.03635868,-0.091914855,0.0016931557,-0.091687046,0.032189198,0.009027243,-0.08707383,-0.08441605,0.03848114,0.061638445,0.016610248,-0.05278084,0.014669414,0.084817186,-0.067111745,0.056929506,0.04801355,-0.008896411,-0.03457879,0.05008579,0.0067037665,-0.037200894,0.06252635,-0.045077085,-0.06902704,-0.0035552846,0.07217817,0.096166864,-0.08862756,0.053299308,-0.005559131,0.03682766,-0.038734637,0.029964162,-0.003971002,0.012939713,0.046056423,0.033270568,-0.04273972,0.122267224,-0.032838453,0.0121498415,0.029809995,0.021160446,0.035915714,-0.024531996,-0.015780838,0.019225046,0.026096279,-0.07576198,-0.0011745996,0.09692959,0.023249894,0.055582173,-0.052565496,-0.007512534,0.016194887,0.059251416,-0.053686637,0.008479192,0.039883476,0.05175884,-0.066233724,-0.03429871,0.13421051,0.01872672,0.041926812,0.059805993,-0.08162031,-0.05745083,-0.00025126498,0.07808884,-0.07917152,-0.06816316,0.012421038,-0.08225592,-0.065718144,-0.01511888,-0.008276106,-0.050606553,-0.009772806,0.07542625,0.037829064,-0.096968055,0.022209762,-0.0041650226,0.037019357,-3.544363e-33,0.05274605,-0.07219892,-0.0019566584,0.045233645,-0.021057881,0.0803772,-0.03453453,-0.0103740115,0.056664813,0.03438803,0.089665435,0.020621546,-0.10325014,-0.020274965,-0.0054963483,-0.011394224,0.04444188,0.07659989,-0.0049925973,0.105799414,-0.013668508,0.0770472,0.028440675,0.06460304,0.07417961,0.034092776,0.029902821,0.018467367,0.060427617,0.02837299,-0.042331483,0.0032245652,-0.06969832,-0.10246019,-0.010178683,0.024196487,-0.033142567,-0.037549213,-0.05175183,-0.04405847,0.019467972,-0.031619076,-0.006526828,0.08104944,0.010136968,0.08957936,-0.043229215,0.038286123,-0.05408635,-0.01722352,-0.04715631,0.05744919,-0.016414179,0.0039975084,0.114584185,0.05756088,-0.010987503,-0.012787576,-0.015911276,-0.04031514,0.023684407,-0.032508805,-0.032901544,-0.06810683,0.024501223,0.014342601,0.01367344,0.044566114,0.11142002,-0.042134188,0.111847565,0.05961821,0.035579465,0.00547634,-0.108917326,-0.09482061,0.03348624,-0.11002067,-0.045036625,0.030801497,-0.0038540724,-0.007641022,0.0037879313,-0.080476016,-0.06958855,-0.039068174,0.025691193,0.017564004,-0.053460382,0.03701823,0.01643941,0.03130733,0.042966112,0.056072496,0.037177335,-3.313991e-08,0.03492039,-0.027042976,0.09805492,-0.066957645,0.0032918814,0.04034066,0.075102955,0.038476396,-0.030024845,-0.024101887,0.0096101,0.034822017,0.11534019,-0.020506946,0.07913311,-0.02653476,0.005528716,0.0062227687,-0.046934284,-0.030521149,-0.06894494,-0.055815313,-0.09321994,-1.7029392e-05,-0.036380094,-0.032365423,0.06585063,-0.008519512,-0.05145646,-0.021444248,0.046811692,-0.081054635,0.038485218,-0.015046552,0.05000357,0.017256,-0.013410826,-0.033828437,-0.0022345167,-0.006431334,0.00569957,-0.0079061305,-0.05084898,0.07315009,0.030439502,0.06032351,-0.045883916,-0.02225285,0.001874856,0.013664693,0.06624115,0.04652401,0.01296092,-0.009340446,-0.07176718,0.08744928,-0.012844801,-0.030978559,-0.023870662,-0.03579282,0.057079263,-0.027500292,0.13334407,-0.024647916 +1.3.1.30,Testosterone and 20alpha-hydroxy-4-pregn-3-one can act in place of progesterone.,384,1.0,-0.013274877,-0.0400544,-0.04885303,-0.027701044,-0.021397054,0.04980183,-0.00091851945,-0.003978021,0.02640045,0.055782255,0.0495328,0.06704167,0.012480082,0.033929963,0.1236998,0.042842057,-0.0065656146,-0.005951548,0.030017048,0.004076181,0.04120699,-0.07730549,-0.024817558,-0.0416732,0.015494076,-0.06973146,0.0047369995,0.10384477,-0.02581421,0.030862512,0.042069882,0.03411713,-0.012027888,-0.018968804,-0.0925842,0.017076213,-0.12808448,0.007335449,0.06498387,0.08685811,0.062387764,-0.045877874,-0.07025189,0.021032268,-0.010944458,0.050909184,0.010969481,0.014372808,0.01907502,-0.018145459,0.03573698,-0.15075336,0.045081977,0.10357769,-0.00855089,-0.0050285,-0.029210178,-0.0072001745,-0.019425184,-0.012342192,-0.0671253,0.011375177,-0.019661197,0.00018369594,0.04135641,0.075157814,-0.04453708,0.015915798,-0.07903216,0.021054152,0.08625729,0.016881984,0.007448156,0.026309123,-0.062037647,0.031972855,0.012134766,-0.007848864,0.040161207,-0.030199641,-0.054077167,-0.0046020304,0.01967241,0.07234049,-0.057979226,-0.042477727,0.0012011571,-0.065134965,-0.026296416,0.05742511,-0.1300097,-0.06483183,-0.044236723,0.07715133,-0.05637327,0.08026366,-0.08367361,0.008914635,-0.050891362,0.0037826071,0.015283653,0.07434743,-0.057637755,-0.0008090733,-0.07747309,0.09022908,0.010761023,-0.02096865,-0.10270471,0.028921949,0.0051478744,-0.08518605,-0.018296221,0.06607605,0.023750884,0.019739194,0.015191486,0.046123248,-0.005644247,-0.16511586,-0.051663674,-0.020640029,0.079146825,-0.06126029,-0.00021122338,-0.023174653,0.029912287,-1.3093335e-33,0.048785564,-0.040524226,0.021893114,0.06356184,0.0022188006,0.13726182,0.039982393,-0.019222476,0.022654347,-0.07775487,-0.0035305417,-0.011098477,-0.026238248,-0.036122102,-0.04248861,-0.03990828,0.030146299,-0.020045144,0.028953275,0.018967925,-0.009595082,0.050729383,-0.09185255,-0.06144931,-0.057721768,0.0680312,-0.0024013852,0.014419274,-0.057107102,-0.011159473,-0.017382048,-0.0076855654,-0.0012029394,0.035475977,-0.021061206,0.020869104,-0.038221426,-0.01196831,-0.01801507,0.021824948,0.003773967,-0.05434157,0.0036532804,-0.05425725,-0.022272348,-0.10352845,0.02760749,-0.0062136296,0.076300755,0.03520635,0.016749151,0.054473966,0.05757803,-0.0056435545,-0.07009386,0.07907699,-0.051569562,-0.052168738,-0.019113615,0.03418916,0.00847945,-0.00873087,0.028940244,0.0007995865,-0.03248584,0.058677055,-0.05609101,-0.04275711,-0.050994683,0.13137308,-0.0072970446,0.021285348,0.07140077,-0.0063486034,0.022092197,0.08242849,0.024560206,-0.004768769,0.010876935,-0.05567246,-0.013363058,0.014544513,-0.0016145248,0.088334754,0.012103237,-0.0020411317,0.052174527,-0.06272421,0.07767443,0.0975481,0.039054975,-0.067563534,-0.037893545,0.04527917,0.013299074,-7.915682e-34,-0.0068584722,-0.033127952,0.036343116,-0.0355948,0.029183343,0.11121867,0.10821097,-0.006803348,-0.027901443,0.06276133,0.021132318,-0.020395612,-0.06868506,-0.060252886,0.00746676,-0.01760858,-0.047857657,-0.025200108,-0.041380506,-0.05814787,0.059603836,0.14489709,-0.005770646,0.09863365,0.040375944,-0.035625,0.07610664,-0.03144551,0.040126503,0.16158566,-0.035836104,0.0021112766,0.05879141,-0.00975147,0.04859841,0.05671002,-0.018228197,0.059325933,0.0015153758,-0.08200753,-0.061710387,0.004097014,0.0033878612,0.02146792,-0.023238419,0.1044938,-0.020240668,0.064756155,0.047422443,0.11434284,-0.05770303,-0.03796337,-0.042029552,-0.042672243,0.0022645944,-0.06817318,-0.05138144,-0.059788354,0.020861752,-0.035492927,-0.019233832,-0.03736842,-0.020049982,-0.037798695,-0.011587394,-0.011521305,-0.06753777,0.02570391,0.020685712,0.09831509,0.07081279,-0.05647247,0.009549829,0.035284285,0.017177798,-0.06318961,-0.037138302,-0.041431177,0.0016671009,0.023709957,0.008650481,-0.02914002,0.010093256,-0.009847189,-0.06996003,-0.022684516,-0.003700698,0.0030342948,-0.03559263,0.018759258,-0.024494113,0.10151377,-0.069989644,-0.017180342,-0.051793464,-2.7430259e-08,-0.01676657,0.024066394,0.0975451,-0.04516273,-0.03764493,-0.09537763,0.018362585,-0.01964033,0.112371355,-0.014604331,-0.055039648,0.029271964,0.03603371,-0.07746443,-0.012769466,-0.028350353,0.014120207,0.055350043,-0.04968623,-0.082082346,-0.0048412154,0.0010037042,-0.05319179,-0.022803139,0.0075638667,0.027193144,0.013456035,0.057958167,-0.039271925,0.0046346495,0.08483528,-0.04426488,-0.002662001,-0.012372904,0.004915279,0.10554315,-0.01448688,0.047758404,-0.037136033,-0.054347903,-0.04642492,-0.11977473,0.056431748,0.06512455,-0.06659583,-0.005353376,-0.0051347013,-0.04087243,0.017752936,-0.02040116,-0.07164176,0.029064618,-0.010923599,0.00756581,-0.06956731,0.045300156,-0.014795074,-0.07618597,-0.007263709,0.011166507,0.0033657392,-0.0039193416,0.11822655,0.04871091 +1.3.1.31,An iron-sulfur-flavoprotein (FAD). Acts (in the reverse direction) on a wide range of alkyl and aryl alphabeta-unsaturated carboxylate ions; but-2-enoate was the best substrate tested.,384,0.99999994,-0.06142454,-0.087274656,-0.07794613,0.014349316,0.07926922,0.02470549,0.0017744767,0.05588989,-0.00776843,-0.05330205,0.030207008,0.034790277,-0.08444546,0.025846612,-0.090206355,0.011169133,0.003969,0.032137316,-0.003162652,0.005174487,-0.026707515,-0.042367674,0.027926931,-0.05650417,-0.00049983594,0.012581851,0.0064637563,-0.024054253,-0.04169687,-0.046546243,0.06628735,0.033396464,0.022192352,-0.008399508,-0.06279741,0.058869317,0.023264678,-0.03057945,-0.036803022,-0.04260091,0.036341827,-0.022109313,0.0207902,-0.03845394,0.039732084,-0.044739652,0.013293452,0.007760368,-0.014818839,0.03507941,0.0063731996,-0.020597827,-0.108896084,0.064447135,-0.040700592,0.029513134,-0.010944682,-0.03596209,-0.013569961,0.026906786,0.052533988,-0.02929813,0.02433522,-0.028350567,0.024077063,-0.021088833,-0.0018152022,-0.026710248,0.03913884,-0.00021246006,-0.00028692014,-0.012939008,-0.13200742,0.020416616,0.03771733,0.05503071,-0.044476166,-0.097411945,0.10181227,0.0052274605,0.03191583,-0.020055784,0.10522372,0.09723091,0.07955379,-0.02301418,-0.023542166,0.0038193213,-0.0540199,0.07199928,0.007013444,0.049318083,0.029274048,0.023944749,-0.036056127,0.07003834,0.014891086,0.009728297,-0.058978148,0.03470149,-0.030198153,0.023642171,-0.0084504625,-0.037469544,-0.021596303,-0.075869314,-0.013111899,0.098288015,-0.0630736,-0.029669415,-0.014630628,-0.04856231,0.030549338,-0.081406265,-0.031573396,0.056884225,-0.01865826,-0.018957308,-0.020481339,-0.027455222,-0.02243668,0.13380627,0.039039176,0.106611975,0.08136543,0.027230324,-0.09665799,1.9072732e-33,0.06826615,0.05239129,0.028032783,0.006551621,-0.04992845,-0.039091732,-0.09317962,-0.0038625952,0.01022625,0.0111010745,-0.045133296,0.00838345,0.028383281,-0.020768771,0.06382757,-0.027597392,-0.061191626,-0.009362062,0.05485287,-0.09632312,0.013197906,0.08051701,0.00070976454,-0.052804142,0.012846379,-0.03925772,-0.04543332,0.02073024,-0.015406853,0.023127593,0.04478415,-0.0461882,-0.07740739,0.009757218,0.017814768,0.026264014,-0.10414299,-0.07204974,-0.084554836,0.044859935,0.06463026,0.019167071,0.027339356,-0.026072312,0.07506162,-0.062361363,-0.09348363,0.0946589,-0.01888896,0.038356893,0.040130388,-0.027573029,0.05557645,0.08129297,-0.07824136,0.024148464,-0.014726379,0.019890245,0.026679141,0.048101496,-0.0011244137,0.030809296,0.005534916,0.07587653,-0.08008848,0.003917594,-0.08419994,-0.03623231,-0.041181237,0.11553366,0.057394326,0.007576111,0.09199353,0.027879389,0.019645816,-0.049154922,-0.0555124,-0.058516156,0.028620789,0.016165264,-0.05343198,-0.0026412893,-0.06079981,-0.015201554,-0.09786125,-0.010602578,-0.06597293,-0.051982034,0.034907896,-0.003149993,-0.018540028,-0.010798219,0.011263134,0.00051329384,0.031742718,-1.8501409e-33,0.010744609,-0.09661369,0.044309538,0.07047875,-0.026226657,0.027294897,0.09050367,-0.029209448,0.037631374,0.046183627,0.08141875,-0.019937653,-0.013074174,-0.010699832,0.074413955,0.063230984,-0.026059728,-0.013638217,0.11781759,-0.020948602,-0.07543494,0.027956065,0.057987962,0.11566693,0.06732552,-0.018646989,0.052544042,-0.062467363,0.038334936,0.06429144,-0.026483426,0.033089004,-0.009017266,-0.020955205,-0.10600098,0.059430826,0.016291782,-0.011082406,-0.04070815,0.044003822,-0.053831954,0.013423055,0.009516763,0.13156827,0.03295413,0.03479449,-0.06665127,0.07819786,0.0970533,-0.06722468,-0.0050875135,-0.016228503,0.0037821066,0.024399092,0.029489491,0.09903741,0.07312819,0.05892238,-0.021528542,0.06970608,0.015874792,-0.056411006,0.037779287,-0.11277456,0.048909627,0.065789856,-0.0036422743,0.10001127,-0.020072004,-0.07979915,0.14767464,0.005541603,0.012844479,0.04959225,0.038755402,-0.08604282,0.028285598,0.079353966,-0.009461629,0.007804871,-0.00671446,0.012486783,-0.025262272,0.051996194,-0.028534455,-0.13817763,-0.028656155,0.029908938,-0.0344859,0.05154527,-0.046000294,0.024445733,0.00087659835,0.0014242121,0.008432188,-3.6971567e-08,-0.0025510176,-0.053050324,0.031938087,-0.055271108,-0.04427153,0.031137314,-0.02022507,-0.051597208,-0.02823295,-0.08201266,-0.040905204,0.1166717,-0.044270314,0.023019265,0.06700579,-0.019001879,-0.020147061,0.044093627,-0.07414503,0.0008625464,-0.06682197,0.06227619,-0.075656004,-0.014518492,-0.10024581,-0.013741623,0.030389473,-0.011208687,0.04285733,-0.0030760032,-0.014255025,0.028196981,0.013389765,-0.017834334,-0.07542808,0.052436415,-0.029711954,-0.072640516,-0.06321371,0.05355231,-0.06516704,0.003333404,-0.01724632,-0.03675131,0.027743166,-0.015768908,0.006069586,0.01781484,-0.07493687,0.01107458,0.03026591,-0.03456764,0.02536232,-0.0029912286,-0.019415233,0.036291964,-0.014226447,-0.13042884,0.038120177,-0.02857343,0.04392003,0.012940184,0.079807356,0.0215576 +1.3.1.33,"The enzyme catalyses a light-dependent trans-reduction of the D-ring of protochlorophyllide; the product has the (7S,8S)-configuration.",384,0.99999994,-0.05322456,0.045046736,-0.02304941,-0.023689706,0.034173798,0.015817957,0.0030823783,0.07135409,0.05252312,0.05087206,0.002551832,-0.02521399,-0.07923308,0.0023979929,-0.007875869,0.09553709,-0.10326673,0.03432069,-0.06423901,-0.054960012,0.035319984,-0.048774842,-0.0056428122,0.03325227,0.026407823,0.022050867,0.05670225,-0.005612122,-0.040543377,-0.08269119,0.031906947,-0.009084378,0.0020664425,-0.023040801,0.0076078945,-0.012613649,0.04682061,-0.05181269,0.0059947395,0.036479507,0.0050577186,0.03080512,0.013710831,-0.08272096,-0.11018109,0.048140552,-0.02651106,0.03131018,-0.021502318,-0.090823315,0.049405407,-0.033227682,-0.07841115,0.076611176,0.028952697,0.05727018,-0.00056638353,-0.05446025,0.016568383,0.0056502083,0.046344575,0.0034621533,-0.020857835,0.017965449,-0.010970125,-0.036668155,-0.022131916,-0.05035361,0.020958489,-0.013853963,-0.03578952,-0.04124958,0.0066967136,0.033692602,0.04124505,0.00037613438,0.029839756,-0.046140775,0.021005122,-0.06632797,0.07860776,0.04157552,0.03529556,0.09218938,0.03830936,0.025741706,-0.02498073,0.004693548,0.041298512,-0.024123093,-0.033107016,-0.045374,-0.023818165,-0.052578464,-0.12854908,0.098811164,0.03304575,-0.085769646,0.0052099586,0.017313289,0.07915238,0.010254656,-0.08944234,-0.061916538,-0.043868396,0.018706113,0.0056690834,0.1276301,-0.06326825,-0.030823816,0.06859969,-0.001018709,0.058701884,0.014466286,-0.07412683,0.05783503,0.024413887,0.014752073,-0.010070827,0.006370517,0.0010260686,0.032179486,0.015060216,0.094946854,-0.071431436,0.07488995,-0.09300902,-3.0884994e-33,0.075368606,0.042033423,0.0041511604,-0.008282034,0.0010136389,-0.084127426,-0.03557458,-0.015951253,-0.079401225,-0.080001995,-0.053468194,-0.103298046,0.03684595,-0.04455019,0.009443397,-0.05591553,0.093547024,0.06982979,-0.05099765,-0.018316561,-0.00911993,0.074019566,-0.06967905,0.06028771,0.067536876,0.121388465,-0.033069745,0.048050016,0.096629344,-0.019907694,-0.047440458,0.024287205,-0.056615904,0.0987701,0.06346095,0.019788219,-0.016843062,-0.028085029,0.040341873,0.04087824,-0.015286455,0.0079918085,-0.027827993,0.0012605404,0.06722818,-0.013987766,0.0049673864,0.045455344,0.07399314,0.08146675,0.03055236,-0.014345304,0.060299028,-0.0352788,-0.03647122,0.04844088,0.024143858,-0.03513728,0.07205604,0.024875889,0.00025828846,0.026757646,-0.030929295,-0.020104349,0.016847681,-0.012664987,-0.0544072,-0.075160146,-0.08277611,0.008905032,-0.10766336,0.019040057,0.08362564,0.04168779,0.12296495,0.0051867273,0.02861973,-0.066661224,0.006773384,0.04068781,-0.04534013,0.057958156,-0.0060899635,-0.09711504,-0.043743357,-0.015220533,-0.03421322,-0.06723501,-0.075550094,-0.020483652,0.06253428,-0.06861792,-0.05829319,0.004288555,-0.04239323,1.9325946e-33,0.036400594,-0.057207365,-0.008269213,-0.012017399,-0.009832028,0.035331912,-0.014102708,-0.057993665,-0.03592283,-0.007598396,0.0981328,0.019816054,-0.075984895,-0.0030518288,-0.016182764,-0.030352358,0.042800058,0.121716656,0.027792105,-0.040759694,0.0014375229,0.0574971,-0.0012028741,0.019857159,0.00055687455,-0.043043964,0.014001242,0.041330796,0.10813469,0.0209384,-0.017728377,-0.063090004,-0.0070670624,0.09250739,0.007538075,0.07601375,-0.041718736,-0.00086713425,-0.03386845,0.061988078,-0.076612115,-0.07887729,-0.029741947,0.022099843,0.0479618,0.04104166,-0.060088716,0.03718743,0.041232426,-0.014787896,0.03267966,0.019724295,-0.022833513,-0.028089374,-0.014700608,0.03850104,0.108363554,0.028200684,0.0059458176,0.0019134185,0.033082884,-0.049757555,0.08606716,0.022406483,0.035397567,0.11191733,-0.027525045,0.08326051,-0.0031751906,-0.09086551,0.052836567,0.025182227,0.014512733,-0.011952222,0.03344148,-0.14182714,0.0062262556,-0.030078253,0.013256796,0.01402988,-0.06366464,0.0037393237,0.036811497,-0.06629621,-0.009094764,-0.034106728,-0.00058459834,0.033342257,-0.036825366,0.02396769,0.037624616,0.04099337,0.03780517,0.05879219,0.098716594,-2.8754977e-08,0.060398858,-0.073365584,-0.014675485,-0.062704965,0.035680704,0.0067033772,-0.022849314,-0.0043311343,0.06798646,-0.058912475,-0.047805555,0.042467497,0.03505678,0.070550896,0.020816203,0.01527704,0.00069169106,-0.07722537,-0.046608865,0.025483962,-0.04205345,-0.0059712054,-0.10127612,-0.034958676,0.00043380633,-0.03492517,0.06358779,0.09919058,-0.0055755395,-0.026485076,0.06415934,0.01943067,-0.0783285,0.010035736,-0.015330388,0.01901517,-0.040188648,0.017374607,-0.03652146,0.08678264,-0.018130487,-0.041849174,-0.039593734,0.06798979,0.0068738325,0.016449666,-0.018037666,-0.0072817206,-0.050872073,0.08708233,0.047568634,0.013769443,-0.010420816,-0.08170669,-0.1505972,-0.03922009,0.022162588,-0.05322864,-0.084152564,-0.033856906,0.025278643,-0.020515898,0.14011697,0.024060844 +1.3.1.34,"This bacterial enzyme catalyses the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (2E)-2-enoyl-CoA. The enzyme from Escherichia coli contains FAD, FMN, and an [4Fe-4S] iron sulfur cluster. cf. EC 1.3.1.124, 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing].",384,1.0,-0.04343986,-0.019445699,-0.0842647,0.042783935,0.11225103,0.015400541,-0.09722989,0.047905188,-0.0054270327,-0.060047507,-0.001624926,-0.062178746,-0.019741451,0.04329498,-0.045108754,-0.005701491,-0.042517543,0.040954594,-0.02261173,-0.078917354,0.014782114,9.420405e-05,-0.017311126,-0.039608493,-0.0028952544,0.024445547,0.06824383,-0.033862837,-0.04965428,-0.070260756,0.024917169,-0.031162174,0.058443554,-0.08379892,0.07954843,0.03231233,0.088408336,-0.07257647,0.042760175,-0.013876557,-0.034739163,0.028868977,0.0065730517,-0.059697267,0.0076822084,-0.005505285,0.011303627,0.023098338,0.03836609,-0.07505031,-0.03743524,-0.031949308,-0.090832666,0.07005687,0.06309062,0.0011372493,0.01148565,-0.08327026,-0.028512072,0.058818586,0.091296904,-0.04363938,-0.009693504,0.0048511233,0.025562596,0.009706936,0.04286643,-0.064451165,-0.023224503,-0.06995347,-0.03125517,0.0030280284,-0.021334568,0.017934829,0.016993297,0.018978747,0.056553166,-0.038125053,0.05795422,0.015534197,-0.0196987,0.007752439,0.051724438,0.051262207,0.019966828,-0.026394485,-0.032580033,-0.07718437,0.078681484,0.07904243,0.0021745928,0.035642542,-0.013970142,-0.06470168,-0.050557546,0.08708544,-0.02779845,0.07476662,0.04640651,0.011314106,-0.025120033,0.053816527,-0.050693702,-0.06530498,-0.04223942,-0.046181317,0.062120974,0.16607179,0.0022631397,0.014470501,0.014245289,-0.024721667,0.036006723,0.012519622,-0.057157893,0.07357939,0.079207286,-0.050873265,-0.10408557,0.04899064,0.035381943,0.04762417,0.04715603,0.060849596,0.06677831,-0.01742284,-0.14932245,1.0027666e-33,0.045616545,0.09183198,0.06832142,-0.02230706,0.02309319,-0.0133432895,-0.101985216,0.047179516,-0.010059853,0.025850633,-0.061980437,-0.06034509,0.07064973,-0.039118297,0.0046956027,-0.09877686,0.009527283,0.027851772,0.04903833,-0.03551628,0.02555188,0.03338313,0.035194702,-0.00058868004,-0.0012446066,0.041335683,-0.01716165,0.041767605,0.041668948,0.012275299,-0.010519369,-0.079836935,-0.07474879,-0.027170168,0.0694596,-0.06372865,-0.07061564,-0.00806529,-0.08212493,0.07434791,0.05288795,0.08196488,-0.05466275,-0.019883735,0.053612683,-0.09125265,-0.04010541,0.058944907,0.09107789,0.08322704,0.0417783,0.0013286268,0.079911925,-0.023781495,-0.0475724,0.031290073,0.0024984663,0.015554495,0.04435502,-0.004765131,0.018409498,0.085008495,-0.044778857,0.03349649,0.051019125,-0.020523354,0.031969566,-0.05504314,-0.008580253,0.09204098,-0.020310832,0.0082771415,0.08389956,0.023897512,0.023890806,-0.10060272,-0.030200869,-0.017157694,0.06206575,-0.053859934,-0.008921526,-0.0033981148,0.0023090765,-0.059968185,-0.0060411673,-0.014154658,-0.04740116,-0.018846713,0.01506851,0.0224656,0.059490494,-0.08101923,-0.05783162,-0.027167385,0.03675223,-8.237112e-34,0.05905102,-0.06510688,0.00652454,-0.1284864,-0.112832405,0.022589149,-0.007014299,0.014969936,0.061772443,0.07091196,0.143428,-0.029961202,0.050346147,-0.028959995,0.014467504,0.05272095,0.03514431,-0.03386958,0.044077553,-0.017906094,-0.011986444,0.033878908,0.04686055,-0.009349545,0.05085556,0.06975729,0.0046972763,0.054831974,0.048959985,0.0672423,0.0063067754,-0.03907615,0.0005255751,-0.026860991,-0.06664881,0.009775171,0.0017638169,0.040193476,0.039288163,-0.022525053,-0.055756148,0.039334305,0.02251462,0.08879648,-0.015742004,-0.0015918683,-0.06789196,0.03739489,-0.0063248146,-0.030561067,0.006188474,-0.025895184,-0.09802636,-0.03198527,-0.013833917,-0.015575679,0.024145816,0.031150011,-0.070943795,-0.035482258,-0.018130714,-0.10856193,0.05075798,-0.012325527,0.12676916,0.042543232,-0.027562585,0.055003863,0.0057965764,0.0025047015,0.009983303,0.0062380307,-0.010047045,0.012723067,-0.0065119644,-0.020057319,-0.026923893,0.0189566,-0.004085146,0.029688267,-0.03200971,-0.030762242,-0.054882303,-0.056208104,-0.065835305,-0.15648317,0.018810313,0.13423334,0.015719853,-0.003277443,-0.039612416,0.017139744,0.07118897,0.037573453,-0.011552995,-4.0484778e-08,-0.0046116733,-0.12514144,-0.018521458,-0.0030340478,0.019625653,0.018159362,-0.085872106,-0.019396659,0.041509796,-0.029183332,-0.015184512,0.124902196,0.0027670907,-0.03999592,0.064830095,-0.022544533,-0.043969736,-0.0018096969,-0.01911589,-0.04240045,-0.014584845,0.016699964,-0.09745486,-0.0051730294,0.031990085,-0.06264047,0.036219534,-0.037854023,-0.034129277,-0.038263686,-0.03643037,-0.016238153,0.012891765,-0.0070540365,-0.08359198,-0.032044757,-0.025143852,-0.026244806,-0.07663725,0.1066716,0.04215544,0.04384715,-0.08432719,0.019449877,-0.020802623,0.033514246,0.0024834874,0.045005083,-0.023289567,-0.03869117,0.0055864286,-0.035117667,0.012558927,-0.0051069604,-0.09316593,0.052469205,0.027933866,-0.043191075,-0.0068412134,0.03343908,0.013940841,0.0010818978,0.13250239,0.021881092 +1.3.1.35,Also desaturates phosphatidylcholine containing the oleoyl group on O-2 of the glycerol residue.,384,1.0,-0.024741018,-0.010719495,-0.026313886,0.0480474,0.041248154,-0.04714955,0.0035825465,0.024302794,0.027114447,-0.0682908,0.055873875,-0.013105493,-0.079050936,-0.039215486,-0.023967864,0.0064550466,0.041640766,0.014814765,-0.058729913,0.02492528,0.10823645,0.041288655,0.00264907,0.021782868,-0.022993911,0.02951627,-0.04181681,-0.030535452,0.061285842,-0.091064416,0.050585374,-0.040434986,0.05092855,-0.05529301,0.019304251,0.01513322,-0.010683312,-0.012307923,-0.013389935,0.024281358,0.09884684,0.012126661,-0.029903058,-0.007343578,-0.012861585,-0.0033107677,-0.015526536,0.030555304,1.1670853e-05,0.025666445,-0.0029509442,-0.046540275,-0.067095384,0.007176328,-0.016510528,0.04413288,-0.027811097,0.10073036,-0.066796914,0.022173062,-0.0011399175,0.035983864,-0.0038224827,0.017404627,-0.08192672,0.0041869576,0.07816272,-0.08058541,0.067628235,0.04120965,-0.046444084,-0.04185115,0.08618192,0.03264436,0.0336917,0.11138935,-0.0064575803,-0.01774776,0.06350648,-0.107845396,0.059483625,-0.035916444,0.008787172,0.09236534,-0.0042991918,0.06663765,-0.009731733,-0.10967751,0.047048602,0.013126439,0.028042333,-0.040799722,-0.06683316,-0.013502093,-0.039909314,0.006868668,0.04831757,0.03513617,-0.031932686,-0.016072208,-0.018673968,0.011554036,-0.052862186,-0.046889495,-0.08498575,0.062650524,-0.014772442,-0.11633178,-0.013008281,0.0037429677,-0.023208052,0.02026537,0.072530724,0.008811637,-0.006314033,-0.016740546,0.009525585,-0.008109842,-0.0198777,-0.03930752,0.030545678,-0.07637533,0.011365621,-0.0056010457,-0.08845983,0.029250072,-0.023622504,3.162741e-33,0.06053888,0.03473141,-0.022787632,-0.055509117,-0.026282817,-0.09321133,-0.09447607,-0.025535025,-0.063669905,-0.015633268,0.012745874,-0.05404478,-0.030474667,0.10290246,0.01499161,-0.054398045,0.014954144,0.05163822,0.10011507,-0.1018884,0.014875243,0.06047911,-0.035396166,-0.045141943,0.01890304,0.07354477,-0.046705246,-0.037251912,0.05713644,0.028641842,0.096019596,-0.121823706,-0.09048483,0.05473415,0.008612259,0.05720738,-0.04013961,-0.075411394,0.08098992,0.020528002,0.018371057,-0.0073758014,0.013234043,0.03811275,-0.006000882,-0.014871476,-0.05848804,0.10387486,0.12559384,-0.011058744,-0.008771903,-0.06525613,0.03721271,-0.006522659,-0.03210136,0.008005926,0.0024974665,-0.02415405,-0.0019432537,-0.00055598974,-0.030858818,0.13664424,-0.067193374,-0.044518545,0.07263683,0.034862127,-0.096335694,0.00040074575,-0.016714297,-0.027615534,0.004987051,-0.013317786,0.0673711,0.08181888,-0.012425183,-0.029394185,0.05717133,0.06202899,-0.026523637,0.055606253,0.078638166,0.017438341,-0.048934378,-0.032208417,-0.09039026,0.048819523,0.014794325,-0.0070282174,0.002968508,0.037150107,-0.033115268,-0.030273769,0.0023417529,0.0055158534,-0.08037613,-4.0678136e-33,0.060021695,-0.049696915,0.105109304,0.049243126,-0.02526625,0.017489437,-0.02470327,-0.01491259,0.06410419,-0.0057584564,0.029602604,-0.0014644325,0.0406025,-0.01918186,0.006498964,0.011490819,-0.06094915,0.079509564,0.018251957,-0.08197604,-0.0074160686,-0.004112162,0.018367644,0.100597,0.05570892,-0.024239816,-0.013351191,-0.047794588,-0.05517009,0.058554094,0.023652429,0.020718973,-0.046082385,-0.06680865,-0.0408466,-0.0025330847,-0.050385036,-0.02569884,-0.07410969,-0.026124187,-0.05263015,0.00077483477,0.16916972,-0.06270685,0.076096505,0.06221712,-0.043024253,0.0041927435,-0.0516081,0.0077889482,0.03996603,0.04718049,-0.060692787,0.03334554,0.03928194,0.14025415,0.007905275,0.0039458536,-0.004377627,-0.0848025,0.027770251,-0.024263121,-0.069785945,0.016533569,0.063312314,0.05146285,0.0461193,-0.033834163,0.018957717,0.0022415128,0.040201243,0.009976892,0.02397845,-0.027403422,0.003954449,0.061996512,-0.07189387,-0.046130404,-0.042440187,-0.025701914,0.040240347,0.00980807,0.045121603,-0.07757304,0.0050409674,-0.003365414,-0.089905225,0.0943662,0.015443105,0.033342656,-0.054443154,-0.06865171,-0.021730624,0.04433412,0.07400301,-2.6803658e-08,0.03211327,0.044122223,0.03793904,-0.04058088,-0.06183393,-0.052418627,0.04858384,0.007138539,-0.0284198,-0.045899473,-0.038926873,0.056938812,0.003927108,-0.07188976,0.036927156,0.041586768,-0.028554369,0.023364574,-0.025256287,-0.06203684,0.04217329,-0.043044526,-0.035708997,0.027299242,0.017677607,-0.044373665,0.0777599,0.054451432,-0.037782997,0.063394554,0.0311247,0.00431808,-0.01935732,-0.059103988,0.051275562,-0.022267705,-0.06455133,-0.031153606,-0.07357205,0.14141051,-0.01871116,0.0013298277,0.050782267,0.051786054,-0.0010085504,-0.010203204,0.05288323,0.011851166,-0.043271,-0.005132077,0.0007932008,-0.017917402,-0.042256564,-0.03847758,-0.18954371,-0.063016504,-0.018523954,0.018317116,-0.029692747,-0.056106288,-0.034591336,0.050923128,0.15515342,0.01038892 +1.3.1.36,Involved in the interconversion of heteroyohimbine alkaloids in Catharanthus roseus.,384,1.0,0.027918937,-0.016355237,-0.1064032,-0.010205952,-0.09964911,0.019934274,-0.03765245,-0.0052443473,0.02012306,-0.05639419,0.0059700483,-0.011862549,-0.010089674,-0.04807036,0.0031787762,0.06499869,-0.039602943,0.047523703,-0.065250196,-0.019713936,-0.013400512,0.05996479,0.017658314,-0.009327038,-0.003977528,0.07053999,-0.049161978,-0.0046021785,-0.0061833686,-0.03600193,0.023869455,-0.038524296,-0.031484764,0.028007211,-0.06274685,0.030261984,-0.090360306,-0.017265467,0.09578689,0.11082742,-0.0023634417,0.03774495,-0.042157933,0.028151045,-0.09438036,-0.03266267,-0.058733426,0.03125968,-0.004429037,0.0008625875,-0.015760018,-0.0371625,-0.019200016,0.07334163,-0.01661449,-0.105082266,0.010185539,0.08068061,-0.042040177,0.08043698,-0.00032530248,0.07930868,0.043225925,-0.01021643,-0.048169345,-0.016773995,-0.014072895,-0.011066292,0.1163845,-0.032310124,0.058150887,-0.012378112,-0.016368497,-0.041232474,-0.05913854,0.06355624,0.021430913,-0.006463316,-0.058374677,-0.018990992,0.003922536,0.070332825,0.03989544,0.09787046,0.0040124897,-0.0653798,0.032367658,0.090998515,-0.007755002,0.02114304,0.11579936,0.014473215,-0.019120187,-0.028042234,-0.022872074,0.004683238,0.050280694,0.012596377,-0.07218941,-0.01581138,0.053269297,-0.050574236,-0.101059206,-0.01980018,-0.038160186,0.02272697,0.0016439921,0.01587985,-0.06804488,-0.026178477,0.07635483,-0.046737537,0.00059239025,-0.00050393597,-0.046176996,0.019187499,0.049920756,-0.025333727,-0.05443382,0.022540182,-0.09435513,0.0122338,0.06858386,0.013056804,-0.027851867,-0.03925291,-0.054902293,1.518932e-33,0.014235474,0.008812716,-0.04233884,-0.021363148,0.045815613,-0.012611922,-0.051569983,-0.004486081,-0.026494859,-0.026562052,-0.1204716,0.06808357,-0.033398878,-0.067885846,-0.0009052088,-0.009222568,-0.01933411,0.013741648,0.1053855,-0.022842411,-0.02253243,0.012189919,-0.072217464,-0.005910645,-0.084634125,0.08242934,0.045132942,-0.009798785,-0.028272875,-0.026003879,0.01535615,-0.11800711,-0.03014585,0.027666362,0.008791997,0.024853608,-0.03697889,0.007168137,0.0086925,-0.00524467,0.020902235,0.037039366,-0.008865575,0.038936254,0.08665064,0.06581035,-0.061221894,0.10616366,0.053859223,0.00761566,-0.049201157,-0.060207736,0.14529935,0.08497084,-0.11505583,-0.0038829192,-0.0013832763,-0.020167978,0.05653878,0.05877847,-0.061051797,-0.00068079715,0.016743675,0.043623235,0.029537752,-0.037303284,-0.025297504,-0.011110159,0.040497042,0.04854555,-0.030534338,-0.060501903,0.0052659977,0.009756792,0.031225795,-0.039335806,0.027135586,-0.006852693,0.0021395776,0.098040745,0.08698529,-0.02428072,0.015455573,-0.016623562,-0.06658484,-0.015311994,-0.018164303,-0.009593494,-0.04467518,0.09153193,0.02523576,0.06993201,-0.020371597,-0.068416595,0.13786045,-2.2866216e-33,0.11234714,-0.07465724,0.0436883,-0.053223647,-0.047269203,0.08628778,-0.048714817,0.02362996,-0.0010537539,0.078797475,0.016953077,0.03404214,0.00727102,-0.01027203,-0.108151294,-0.122746654,0.011468465,0.15694351,0.064083844,0.052826066,-0.13078572,0.038967095,-0.065111645,0.03174907,0.024833491,-0.010786321,0.009627134,0.009465159,-0.028962107,0.047175024,0.10687329,0.0123798875,-0.084167525,-0.029464696,-0.015902342,0.062081184,0.010635632,-0.010747372,0.028008597,0.044519655,-0.039831154,0.012872408,0.068960726,0.022091007,0.0880006,0.040927343,-0.0756963,0.10262943,-0.09423475,-0.035742108,0.01867855,0.017419156,-0.009699231,0.0022849713,0.041187864,-0.042149547,-0.019564858,-0.02781939,-0.0030560782,0.037169162,0.03544887,-0.083225556,-0.036437403,-0.014396154,-0.076445565,0.04787631,0.036780555,-0.0028598234,0.08981699,0.011594078,0.021850947,-0.008627052,0.05957673,0.034934465,0.017335027,0.022449292,0.038722128,-0.035794973,0.039680596,-0.07639618,0.07242642,-0.008649918,0.056123905,-0.073684946,-0.027607013,0.007902506,0.042126495,0.11342288,-0.08948137,0.0013652156,0.019250415,-0.032270547,-0.0462237,0.010459083,0.050679974,-2.141772e-08,0.04304634,-0.026370492,0.012452614,0.03819186,-0.01644779,0.0204724,-0.016652236,-0.030850219,0.023286905,-0.018832847,0.03266956,-0.017548867,-0.028721828,0.06048311,0.018935872,-0.06177097,0.05193206,-0.009630886,0.022924121,0.08505269,-0.086484626,0.0059684543,0.007382029,-0.07042142,-0.0009971325,-0.04161977,0.04934704,-0.024527838,0.0197833,0.028450899,0.07202031,-0.020685054,-0.0180699,-0.046178676,0.015829643,0.00049945136,-0.010749702,5.656511e-06,0.07607125,-0.122819245,-0.053505443,-0.00816333,-0.020102331,-0.009268884,-0.054458205,-0.027880888,0.04060006,0.022644892,-0.018417297,-0.031265806,0.049487267,0.021563513,0.05563836,-0.1065306,-0.09650376,-0.024223901,-0.013976874,-0.052930728,-0.074987724,-0.09701978,0.043546584,-0.0760352,0.06754906,-0.009372971 +1.3.1.37,Not identical with EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].,384,1.0,-0.12091414,-0.027219191,-0.060364585,-0.044598553,0.05559085,-0.024528759,-0.112466194,0.065454096,0.015390491,-0.08070142,0.042518828,-0.07538197,-0.047288258,-0.0042643533,-0.013383797,-0.04734745,-0.0246341,-0.055661418,0.038453404,-0.03417915,-0.034499668,0.037209753,0.011466826,0.03246668,0.1467651,0.014840986,-0.0007218119,0.061116144,-0.07024216,-0.11920646,-0.03911658,-0.029235393,0.0072662462,-0.0523586,0.044012375,0.041019563,-0.040284935,-0.037001323,-0.015623316,0.021548536,0.018304138,-0.017408414,-0.077387005,0.003914419,-0.06538593,-0.04761617,-0.06476942,0.096933775,0.0050524855,0.012124231,-0.0045009265,0.009229484,-0.011781364,0.016699394,0.07482312,0.00016362726,0.00424445,0.006093663,-0.08052688,-0.023300504,-0.010972886,-0.084187746,0.012168887,0.02317481,0.027083928,-0.013245782,0.09002589,-0.14206392,-0.010729343,-0.033189945,-0.104545906,-0.040090177,0.02211175,0.055596434,-0.027730051,0.06481326,-0.01937122,0.0074163373,0.023068897,0.003597632,0.0039980393,0.00029958008,-0.043386366,-0.005184793,0.041982822,-0.030560367,0.01723882,-0.015663834,-0.027044164,0.0030293819,0.036793154,0.01009048,0.012021827,0.050473567,-0.0961281,0.08543885,-0.0026476502,0.10568782,-0.0055653714,-0.076342024,-0.0051880633,0.13838312,-0.015842345,-0.03504994,-0.040598754,-0.0055675823,-0.0026912072,0.114570215,-0.07639565,-0.03448339,0.027047228,-0.07005475,0.05136602,0.021252837,-0.02792978,0.092217624,-0.040016815,0.0077816104,-0.039334275,0.027709726,0.056461636,-0.044755057,0.04382868,0.04381324,0.024494609,-0.015952501,-0.09381098,-2.6284781e-34,0.061304808,0.055900298,0.012000062,0.023848318,0.007114352,0.025846645,-0.120631784,0.11520349,-0.07002467,-0.017062042,-0.0051760837,-0.0031916525,0.07544099,-0.03845357,-0.01940426,-0.028909951,-0.030007677,-0.012474086,-0.031757575,0.016070822,0.06301073,0.08274288,-0.014644404,-0.016904954,0.004098714,-0.022162331,-0.07756767,0.05141833,0.01403609,0.018348165,0.022050537,-0.10230623,-0.025226332,0.035277184,-0.003812781,-0.06961255,-0.021026319,-0.076400794,-0.0038161946,0.09102577,0.031551167,0.08788831,0.034770627,-0.06746827,0.018761305,-0.08522327,-0.026873723,0.05558461,0.060828645,0.041392963,0.005228019,0.029873194,0.104861334,-0.0938894,0.035821684,0.02534527,-0.031997953,0.060938396,0.011675119,0.07548122,0.04521982,0.1025597,-0.022689912,0.010782495,-0.02804216,0.044522244,-0.096641295,-0.03774187,0.0025897643,0.04529109,0.020648906,0.05824761,0.0876325,0.050620936,0.058507495,-0.04881977,-0.018167797,0.04908484,-0.015162981,0.036341015,-0.08251601,0.0310422,-0.023955666,-0.035907846,-0.041309983,0.020249909,0.043374702,-0.008033813,0.023779048,0.05225456,0.07775826,-0.009465009,-0.020493226,-0.06406727,0.063596934,-5.347989e-34,0.052532226,-0.02523099,0.024650121,-0.1294984,-0.024364972,0.09301953,0.058262262,-0.03863692,0.048396036,0.003740131,0.15898332,0.07791035,-0.029711355,-0.06907439,0.090978414,-0.0317312,0.012313626,-0.0026689616,-0.013777663,5.7848625e-05,0.030201305,0.0475246,0.02349465,-0.015006452,0.044481028,0.009637161,-0.05368528,0.019060083,0.040044628,-0.017939243,-0.037560605,0.042844824,-0.029727941,0.04312758,-0.009978669,0.039666463,-0.09246323,-0.02810859,0.017386826,0.024643121,-0.04142782,0.019842498,-0.038922947,-0.015790028,0.072994985,-0.0066020745,-0.0479618,-0.0043302807,0.036680974,-0.109801956,0.005052738,0.05043511,-0.060499877,-0.0083816955,0.016526211,0.02176972,-0.0028435455,0.055465613,0.04628719,-0.018139081,0.006955669,-0.0027467497,0.0064965785,-0.009769018,0.019227741,0.013508881,-0.028859785,0.008019315,0.039360564,0.012342554,0.027865369,-0.043129023,-0.009707523,0.031044897,-0.01198383,-0.108881444,-0.034846984,0.03971901,-0.05326169,-0.061225485,0.010048833,-0.012312936,-0.06182721,-0.015663268,-0.02297208,0.011499717,-0.0250733,0.022057839,-0.042978566,0.043893985,-0.053883445,0.025067372,-0.07558836,0.10985016,0.05225262,-3.1038727e-08,0.107592285,-0.036495447,0.031147892,-0.014389202,0.08465031,0.030692855,-0.050476216,-0.06702983,0.038047023,0.026508447,-0.017903503,0.10007293,0.09902746,-0.014026022,0.019468218,-0.015056254,-0.027882686,-0.018253649,0.013750286,-0.006630191,-0.02209586,0.02355816,-0.099181734,0.012081486,-0.022071885,0.016201243,-0.030925883,-0.07190662,0.032506023,-0.051280506,0.058811918,-0.01044947,0.108331256,-0.0151209235,0.024104185,-0.03088014,-0.060057763,0.062766716,-0.10386294,0.10317972,0.028118344,-0.10082195,-0.021988742,0.051518977,0.04989659,0.018929865,0.052386135,-0.06381271,-0.04753041,-0.048152234,0.011994961,0.0053541437,0.014714199,-0.03953215,-0.037352964,-0.005788565,-0.048199736,-0.07706968,0.01163843,-0.0014460171,0.030500652,-0.012559725,0.11965057,0.024706805 +1.3.1.38,Not identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].,384,1.0,-0.12313204,-0.031227194,-0.070475005,-0.043260198,0.06717143,-0.038825776,-0.11232639,0.0622709,0.030657135,-0.09150592,0.043344542,-0.07410154,-0.023811996,-0.013021051,-0.010353889,-0.06348477,-0.02064378,-0.060998198,0.019986352,-0.036791485,-0.041750424,0.03258909,0.012007205,0.0405623,0.11427133,0.018762892,0.0074695093,0.07672585,-0.075082734,-0.10010247,-0.020034574,-0.027462715,0.012136247,-0.05667356,0.05289096,0.031620406,-0.020875987,-0.040679887,-0.00975672,0.018698819,0.016438104,-0.008936236,-0.06818442,0.014765136,-0.06474432,-0.048887365,-0.0716395,0.09294615,0.0014548135,0.009719792,-0.0030886633,0.0016996562,-0.02048285,0.009559647,0.057245795,0.008088204,-0.0004037837,0.0029663725,-0.08239359,-0.001077544,-0.0012781373,-0.08692009,0.0147941215,0.01567312,0.031963695,-0.008536902,0.09352553,-0.14464094,-0.008398321,-0.037517074,-0.10653198,-0.035405334,0.008216912,0.06318814,-0.024057966,0.076394476,-0.026136512,-0.0038765445,0.021757424,-0.015424289,0.009404725,0.023491435,-0.024112111,-0.010180542,0.045781672,-0.033354662,0.028786592,-0.011626746,-0.020512788,-0.011782314,0.042118743,0.008929,0.0097381715,0.04954234,-0.107392244,0.08508787,0.0004130476,0.10972205,-0.019133685,-0.06424408,-0.0030329307,0.12911105,-0.03140291,-0.044816345,-0.04117132,0.0031524994,-0.016304074,0.11527204,-0.07883757,-0.021296578,0.014349871,-0.08702937,0.049239524,0.028555095,-0.009608285,0.09906291,-0.035236735,0.015439918,-0.031475402,0.023655452,0.051671166,-0.045458302,0.048162904,0.04192924,0.02629996,-0.014559333,-0.09782468,-2.201628e-34,0.045678075,0.054531712,0.030115884,0.023456048,0.0033972086,0.019070648,-0.12092866,0.10351216,-0.08307521,-0.02323441,-0.0076117725,-0.007980862,0.0712193,-0.053788256,-0.026668847,-0.030456305,-0.031159567,0.0013445591,-0.041782323,0.020474553,0.07436524,0.0786549,-0.0022931662,-0.008652934,0.016313689,-0.0089686075,-0.083240874,0.054223966,0.02212781,0.018028455,0.025989028,-0.106192335,-0.030012872,0.038679168,-0.007651002,-0.051350534,-0.013233009,-0.06169725,0.0048847045,0.10113825,0.027001146,0.07820282,0.036614884,-0.06960834,0.028228823,-0.090612724,-0.04525258,0.061355665,0.053835228,0.022384547,-0.009635346,0.03301767,0.096001774,-0.08184207,0.018098354,0.016025113,-0.026403142,0.06564729,0.0095135495,0.060954724,0.041558694,0.10416225,-0.041994467,0.017749539,-0.01212083,0.053738493,-0.10015567,-0.02170148,0.0026067088,0.058923993,0.013722224,0.05080822,0.08969171,0.04288156,0.058395326,-0.053551596,-0.03476722,0.053251017,-0.024104968,0.065398484,-0.09623709,0.03294881,-0.02832768,-0.04061844,-0.05521758,0.004745188,0.047798414,0.01335184,0.023551406,0.04998247,0.07806077,-0.016918669,-0.0054307515,-0.06243385,0.062769696,-5.9468085e-34,0.0526465,-0.03188836,0.03276885,-0.122431986,-0.023496717,0.097876295,0.052699134,-0.058365334,0.03742942,-0.0014771015,0.16080071,0.061824497,-0.032601368,-0.058517784,0.09116922,-0.036910783,0.002098809,0.0037949681,-0.010368768,0.023696162,0.03673652,0.024665657,0.027829796,-0.010806683,0.039808523,0.009588065,-0.029934866,0.016347969,0.04656108,-0.008693244,-0.031484123,0.040573396,-0.038042266,0.027341964,-0.01401948,0.03390949,-0.11017661,-0.036357176,0.0062131244,0.026265763,-0.043785658,0.020917721,-0.03030264,-0.018774841,0.062044434,-0.00027124296,-0.049269356,-0.007005115,0.0355176,-0.11999245,-0.0077231256,0.050768096,-0.06360061,-0.0049418774,0.023779217,0.018409021,-0.0052788644,0.05968313,0.04297189,-0.0034610722,-0.0029192816,0.007322842,-0.019048398,-0.0097516505,0.02649082,0.016052658,-0.027253848,-0.0042815334,0.05537611,0.008769189,0.030916236,-0.04095866,-0.00778789,0.024049755,-0.01789833,-0.10302994,-0.040428795,0.048046794,-0.060791593,-0.050969478,0.010486239,-0.017148193,-0.06345259,-0.007888308,-0.026704224,0.019093804,-0.026538622,0.04335801,-0.031414375,0.04662692,-0.04862458,0.021747766,-0.066786245,0.095332116,0.061127823,-3.1196123e-08,0.09966445,-0.041902915,0.039167278,-0.017628592,0.08654804,0.018368933,-0.052174874,-0.08104999,0.045803025,0.027356714,-0.0004541441,0.07921214,0.10199756,-0.03525997,0.025462331,-0.021024792,-0.0029166583,-0.0037273222,0.021199299,0.0047375415,-0.02406574,0.0156373,-0.094293796,0.0052843806,-0.028756531,0.010991927,-0.020286499,-0.072169185,0.027224405,-0.028786236,0.05622266,-0.028088454,0.11080556,-0.019128425,0.028585501,-0.037885517,-0.05195216,0.06497353,-0.099502414,0.084376775,0.042973492,-0.08828357,-0.04254702,0.048259933,0.06780742,0.03524862,0.060917333,-0.06734948,-0.050508603,-0.044755936,-0.026328979,0.01571899,0.022139382,-0.026496759,-0.04512251,0.011789824,-0.06279231,-0.06564844,0.0043023424,0.0075138337,0.032125503,-0.025061244,0.11820346,0.026206682 +1.3.1.39,"This enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl-carrier protein. It is one of the activities of EC 2.3.1.85, fatty-acid synthase system. The mammalian enzyme is Re-specific with respect to NADP+. cf. EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.104, enoyl-[acyl-carrier-protein] reductase (NADPH).",384,1.0,-0.06452641,-0.0018475967,-0.069377534,0.00915764,-0.0001824543,0.054541063,-0.09573262,0.017309105,0.021640867,-0.08137047,0.07898545,-0.06089572,-0.07237561,-0.035228733,0.024365403,-0.0240761,-0.02654054,0.0064945878,-0.01588439,-0.111746155,0.06378248,-0.023000656,-0.0071884715,-0.008179841,0.049205076,-0.04258778,0.02822287,-0.037502084,-0.090709925,-0.12538029,-0.010048384,-0.093656644,0.037838705,-0.053867374,0.042969618,0.03476236,-0.040700197,-0.060747743,0.024702325,0.0051772804,0.03472144,-0.06013908,-0.08647966,-0.01487081,0.01178394,-0.061981086,-0.06462808,0.0640777,-7.467523e-05,-0.016286712,-0.029305715,-0.030414369,-0.020402124,0.0076095383,0.02188572,0.028867122,0.014717336,0.023287257,-0.06306618,-0.019452117,0.09336118,-0.039595738,-0.0034604874,0.018068284,-0.04643803,-0.0736732,0.07299985,-0.11030158,0.013786911,-0.021792846,-0.07859952,-0.0572183,0.01730565,0.03478633,0.023441518,0.043923814,-0.049309157,-0.016905325,0.07016326,0.0023645065,0.038222622,-0.008692334,-0.055112686,0.007955955,0.08457743,-0.01492013,0.00019962771,-0.023850389,-0.043616816,0.041673545,0.007222063,-0.03794766,-0.02233244,0.057341076,-0.10298563,0.04960106,-0.022112822,0.012525995,-0.032960232,-0.05206855,0.048676495,0.090499535,-0.0053096497,-0.08079587,-0.06310168,-0.012073043,-0.039191507,0.10375849,-0.057533585,-0.027837405,0.010726711,-0.05967596,0.05747525,0.043754067,-0.006249587,0.14850575,-0.037760697,-0.044054125,-0.052879933,-0.013250559,-0.016576404,0.0045119897,0.026233677,0.031644974,-0.002981012,-0.07120873,-0.12978268,-5.551872e-34,0.0479097,0.005104839,-0.023178633,0.012936269,0.03294345,0.008153228,-0.12422797,0.08305521,-0.055102192,-0.070408896,0.04292858,-0.07164959,0.06358103,0.026140597,-0.0020107352,-0.060685087,0.036109634,0.060113512,0.044843603,-0.008529709,-0.023600277,0.06667852,0.01809899,-0.053373784,0.013484447,-0.016135173,-0.10628642,-0.018247895,0.02002811,0.03216582,-0.016555158,-0.068806924,-0.07003593,0.069176935,0.060766924,-0.022263179,0.05728994,-0.06102664,-0.015591328,0.07027589,0.03378841,0.06523223,0.039672144,-0.06525965,0.01734237,-0.027921218,-0.041635998,0.059191715,0.062459014,0.008920093,0.061058167,-0.008594097,0.13899538,-0.004474302,-0.014611496,0.029823594,-0.0907517,-0.012556657,-0.037314747,0.03487296,0.042786412,0.07988213,-0.06207037,0.034815088,-0.040652953,0.0030161208,-0.09749548,-0.03117426,-0.029879384,0.13636258,0.050342437,0.033702303,0.11456957,0.024509279,0.031658065,-0.044498067,-0.039066505,0.05036884,-0.050505303,0.038478665,-0.05225773,0.033502534,-0.016940054,-0.016684875,-0.053942606,-0.006350194,0.025547236,0.022421397,0.0927431,0.043303072,0.035953425,-0.04298324,-0.032234814,0.009669684,0.049817864,-1.1879082e-33,0.11238299,-0.04499359,0.05268659,-0.1113954,-0.015552777,0.052119587,0.036566522,0.016782321,0.0060693184,-0.05417402,0.060083732,0.046864454,0.05824266,-0.039081786,0.041958824,-5.793479e-05,-0.02162905,-0.029216558,-0.009095177,-0.057336837,0.01792267,-0.0040693595,0.013013493,0.0780454,0.048251785,0.0046308115,-0.05019446,0.07730886,0.014068541,0.011962278,-0.028564092,-0.0149731655,-0.06369283,-0.02148167,0.007831824,0.08645253,-0.08726789,0.019927619,-0.0045096455,0.06248346,-0.018545482,0.03172494,-0.04229554,-0.019552348,0.11276644,0.024345504,0.012535824,0.020511208,0.035857845,-0.1392589,0.05936489,0.022751408,0.008515498,0.0021919634,0.038354047,0.097293764,-0.0042229276,0.042809494,0.019402126,-0.040319856,-0.041306786,-0.048403095,0.015032015,-0.012693501,0.010100903,0.0015543669,0.0029689295,-0.011590712,-0.0060409205,0.03668536,0.0708396,0.059608847,-0.019113326,0.09276467,-0.028752841,-0.08752415,-0.03919709,-0.03750688,-0.051171843,-0.05272871,-0.032609507,-0.048496544,-0.013731558,-0.063668974,-0.021679398,-0.011443467,-0.016579373,0.05815399,-0.018924318,0.044188354,-0.039780516,0.011656881,-0.091981485,0.10163038,0.026506746,-3.99065e-08,0.057679586,-0.034093812,0.044496525,0.0027641435,0.0072244774,0.04950701,0.06550013,-0.05432595,0.07109158,-0.055006724,-0.05060194,0.11593943,0.078734614,0.05384568,-0.014706696,0.024497967,-0.020961048,0.03422229,0.031676173,-0.048338424,-0.05413933,-0.019981226,-0.09416188,0.027321734,0.008260157,-0.041234866,-0.0027249432,0.028453022,0.043180067,-0.044211403,0.011644074,-0.018723477,0.13158487,0.031092692,0.049291957,0.003217695,-0.047540016,-0.006510058,-0.071296,0.11622217,0.048104607,-0.03243672,0.012970556,0.028571943,0.06044846,-0.02457788,0.031531446,0.006221618,-0.02188114,-0.013847998,-0.025611958,0.030991761,-0.0039841584,-0.035273585,-0.039515715,-0.0053200545,-0.051855143,-0.05500415,-0.0010378509,0.023568096,0.016288005,0.03914779,0.13592023,0.012609401 +1.3.1.40,Broad specificity; reduces a number of compounds produced by Pseudomonas from aromatic hydrocarbons by ring fission.,384,1.0,-0.004159504,-0.024891738,-0.04862842,-0.0016355785,0.0789317,0.035132,-0.04414885,0.08761489,0.015480769,-0.04055579,0.020925837,-0.074851036,-0.08007672,0.010739918,-0.035498273,0.02269967,-0.019250032,-0.006071547,-0.021838928,0.081246406,0.06501845,0.074039824,-0.08778307,0.08272144,-0.021862727,0.029882498,0.07624398,0.0328511,0.0068666036,0.014982038,-0.0050828643,0.09678903,0.05180131,-0.06636757,0.05380961,0.019795533,-0.06656854,0.0861669,0.11641611,0.008908929,0.016763244,-0.002041682,0.013412667,-0.051859036,-0.018079365,-0.005142759,-0.002518524,-0.03403538,0.027368769,-0.14435796,-0.00067022967,0.036869444,-0.07904385,0.08052947,0.007678546,-0.03731385,-0.010336084,-0.014216486,-0.084694415,0.0042386963,-0.0066900244,-0.059401087,-0.01554029,-0.0049199616,0.054340728,-0.0023066977,0.060605843,-0.019860825,0.06303677,-0.037634887,-0.045938186,0.054484226,0.04130653,0.03281571,0.005174544,-0.05857228,-0.044780437,-0.05972398,0.022407282,-0.04565793,-0.056679867,-0.022668632,0.04306514,0.0008798849,0.0102000795,-0.027654355,0.0019394775,-0.029695382,0.026470928,0.07262107,-0.014482382,0.012669663,0.06705088,-0.09031259,-0.08385792,0.104750365,0.044184458,-0.004207299,0.058129024,-0.031875953,0.03944372,0.0062329695,-0.045645423,-0.113882825,-0.04580897,-0.015562072,0.042967476,0.059369538,0.033999227,-0.0674415,0.014021202,-0.00015481199,-0.002627526,-0.12152281,-0.04966862,0.033992033,0.057568494,-0.03287917,-0.023354996,0.057909742,-0.025095558,-0.08167684,-0.01822562,0.0482604,-0.013677792,-0.004998419,-0.10902496,8.806033e-34,0.014553372,-0.03349591,-0.01643173,0.04912412,0.01979956,0.027251594,-0.115786545,-0.15484048,0.00021794456,-0.032386124,0.028348994,-0.0030122546,-0.0034091074,-0.036727637,0.06810483,-0.027603015,-0.065451846,0.077041574,0.072383,-0.028793594,-0.042164844,0.02228053,-0.027888376,-0.009394128,0.05540047,-0.026537161,0.05346521,-0.0118611595,-0.08006651,-0.008932875,-0.014719216,0.08837153,-0.11724431,0.01669528,0.06330123,0.031765725,-0.08438188,-0.07321196,-0.015153955,0.020342218,0.055729207,0.029838106,-0.0043517426,0.018733185,0.07407337,0.01834088,-0.06647119,0.15331283,-0.035959877,0.09573388,-0.007696521,-0.012008223,0.06976657,-0.010693599,0.013324993,-0.01956887,0.018868735,-0.0396234,0.044486,0.035268333,-0.01628529,0.03887238,-0.14241533,0.06470618,-0.021281099,-0.00846209,-0.054054167,0.021487428,0.0823413,0.04149244,-0.1055176,-0.012373944,0.03994041,-0.0049290624,-0.02268243,-0.061637133,-0.04427598,0.019343965,0.03132047,0.060162243,-0.049483914,0.0051367497,-0.002451006,-0.061338175,-0.13685341,0.04534282,0.010933455,0.0113399755,-0.00083847245,-0.016214646,0.064956434,-0.13150258,-0.015259411,0.030189361,-0.03931435,-2.327388e-33,-0.0042176098,-0.063545555,-0.026737118,-0.0031942155,0.027377853,0.010390911,-0.04120485,0.0035143816,-0.039359737,-0.08500317,0.07905215,0.042141087,-0.051602036,-0.002176449,-0.050355095,-0.0050180643,0.08906849,0.02957801,0.051646482,-0.0108020445,0.056535065,0.0008951026,-0.098604634,0.06832423,0.027416466,0.0074604964,-0.13536894,0.065442175,0.04346167,0.08901261,-0.02200062,0.037471473,-0.07654843,0.0134922555,0.026671454,0.003057451,-0.0067793666,0.03346461,0.06762437,-0.013902279,0.017174345,-0.00604807,-0.031111835,0.03248098,-0.025323143,0.040501487,0.0056597707,0.020498786,0.043060437,-0.039085813,0.0009162866,0.0071942834,0.0011624501,-0.028141446,-0.012627547,-0.031073393,-0.052039903,-0.02315855,-0.021302097,-0.044556737,-0.05347424,-0.05525029,0.031262036,-0.006443319,-0.017505404,0.0728887,0.0027224037,0.0018775022,0.012562725,0.01282616,0.007184263,0.017727075,0.027986724,0.0008433736,-0.120396875,-0.041410863,0.040303905,-0.09527026,-0.035796598,0.086845435,0.058576975,-0.041044783,-0.02880339,-0.071189456,-0.0021461544,0.0085562905,0.0029685423,0.021691104,-0.021241548,-0.0014091914,0.008509451,-0.028116705,0.013350895,0.034031868,-0.024304925,-2.5070655e-08,0.05322583,-0.033426143,0.04714973,0.018629948,0.069325194,-0.003760787,0.03371597,0.03850564,-0.0036144117,-0.04328014,-0.02018363,0.046373826,0.010769424,0.08939433,0.15455224,-0.005945719,-0.07645009,0.0147132855,-0.049305078,-0.068591826,-0.029205011,-0.09197468,-0.0707605,0.02607657,-0.00024310121,-0.013990202,0.091093406,-0.0084210085,0.042588193,-0.0058624297,0.017158138,-0.03037338,-0.049807906,0.08882011,-0.024762508,0.037055705,-0.028492982,-0.048499618,-0.019109974,-0.0045215324,0.015142251,0.009094904,-0.08964612,0.055122167,0.08610466,-0.00624297,-0.020844651,0.052890096,-0.021868821,-0.0039273803,0.09775211,0.02957748,0.044628374,0.03176671,-0.07636183,0.06960482,0.051760882,0.046357967,-0.032982264,0.016210144,-0.012517606,0.04235974,0.13150185,0.0002724706 +1.3.1.41,From Drosophila melanogaster.,384,1.0,-0.06022093,0.037125863,-0.027794011,0.02773766,0.034503035,0.0036787104,0.08769358,-0.00812146,0.021184372,0.04845584,0.04766808,-0.06775183,-0.085855074,0.015371638,-0.08382532,0.12467443,0.0024071375,-0.00747995,-0.049648095,-0.031618718,0.058750324,0.11178657,0.060091555,0.006542791,-0.060443666,-0.0019255497,-0.029909102,-0.0041344,0.0690485,-0.10827697,-0.03525285,0.0126802325,0.032349925,0.048828516,-0.027081251,-0.026892329,0.02492204,-0.012913288,0.09235099,-0.0010215122,0.050915137,-0.005067608,0.0033907166,0.0055831126,-0.044247292,0.070792705,0.024968052,0.0074927956,0.08561507,0.02246668,-0.06474805,-0.059366874,-0.05921735,0.035624184,0.026587347,0.055330545,-0.016067391,-0.0708318,0.036594648,-0.037920184,0.038319957,0.052778896,-0.048798684,-0.002332463,0.045772247,-0.06687935,0.008986558,-0.038749106,0.06783462,-0.096361615,0.017202958,-0.02357086,-0.04836656,0.049242206,-0.028378282,0.016821764,0.11279235,0.029032722,0.048943296,-0.005045328,-0.045716632,-0.033331126,0.017531458,0.077764295,0.00837428,0.004274977,0.01312041,0.043423425,-0.04069271,0.041881837,-0.09207451,-0.025624257,-0.0016236354,0.010958812,-0.070772186,0.020693423,-0.02245905,-0.07082634,0.04966569,0.084972136,0.0017859918,0.013169791,0.05631034,-0.018687896,-0.06275008,-0.06918615,-0.038665637,0.0014568154,0.05127002,-0.017311864,-0.0018312661,-0.0097926045,0.031897027,0.10810145,-0.016345104,-0.05926432,-0.07446801,0.034979153,0.091443926,0.03911585,0.037867855,0.050501373,-0.07882474,0.017846148,-0.091433905,-0.06411257,-0.14093417,2.83584e-34,0.064314164,-0.010081552,0.09600654,0.049436968,-0.010157886,-0.042174123,-0.025007222,-0.037972286,-0.016624464,-0.056107443,-0.10379325,-0.055444617,-0.053450983,0.012607386,-0.0075803767,0.038536657,-0.065718815,-0.019383458,0.04409279,0.05458118,-0.07423735,0.03227741,-0.049992036,-0.12800503,0.007999341,0.0057216105,-0.041634638,-0.037834927,0.02219186,0.01046369,0.04900218,0.028741403,0.027075956,0.06681385,0.031964272,-0.010846245,0.031700812,-0.13930975,-0.043816246,0.060053006,0.044244222,-0.0113201095,0.00489506,-0.0018160382,0.025365612,-0.02323348,-0.06754782,0.012728858,0.01861546,0.015609559,-0.026989521,0.015052083,0.09659678,-0.089976005,-0.047686294,-0.038442362,-0.04050366,-0.061093234,-0.06693109,0.027696548,-0.051145706,0.082724676,-0.042398475,0.07381401,0.06741462,-0.03145758,-0.043659914,-0.06278096,-0.054971375,0.001884717,0.011119612,-0.0368768,0.01474951,-0.11881015,-0.01565344,-0.03327926,0.0066818064,0.0081946505,-0.06320655,-0.031543754,-0.051687334,-0.00023093645,-0.042613387,-0.020553172,-0.04246208,0.05553566,0.013653366,-0.046370756,0.06344757,0.066469386,-0.08682087,-0.09616521,-0.023565749,-0.028323377,-0.018930953,-2.2188907e-33,-0.030390996,-0.049351614,-0.0006241358,0.050848074,0.037329886,0.042071,-0.019546077,0.026308194,-0.053920843,0.04781117,-0.04901066,0.060872532,0.114567146,-0.054383405,0.07917348,-0.011380878,0.1269205,0.016438298,0.0039531277,-0.022110943,0.011780946,0.11289017,-0.083225794,-0.00541895,-0.033531208,0.02053973,0.06086903,0.07688319,-0.055437416,-0.030789321,-0.037255432,-0.027270403,0.0011415653,-0.008063211,-0.030576203,0.045793753,-0.0292712,-0.037545305,0.066072986,0.00056767126,-0.013737186,0.053836294,-0.028514076,0.017821347,0.051125612,0.0038208172,-0.0028387827,0.036689125,0.049344096,-0.008958473,0.019885378,0.0030141098,0.03433212,-0.057623822,-0.025202762,-0.033794943,0.029461332,-0.022656888,0.14609928,0.006434762,-0.041068204,-0.058792714,-0.014527998,0.049576253,-0.060487833,0.07062929,-0.012202799,0.08664139,-0.041698605,-0.022008449,0.06891733,-0.0021220187,0.0088784415,0.030825868,-0.09716863,0.048750985,-0.041625373,-0.026065899,0.018239701,0.0044650077,-0.063776255,-0.05426438,0.04454714,0.0014369517,0.061867524,-0.047694873,-0.019570932,0.025624167,0.045503154,-0.03172453,-0.033682827,-0.0018169062,-0.07138722,-0.0030242386,-0.026529703,-2.1001144e-08,0.06808946,0.024604794,0.009552846,-0.016222311,0.03870901,0.083553545,0.04912892,0.0720545,0.037174046,-0.0058115404,-0.025092017,-0.05403871,0.07561318,0.03126548,0.16076297,0.03152779,0.014657744,0.011348269,1.3856254e-05,0.011711322,-0.053893287,0.01572926,0.0646856,0.019491123,-0.06462105,-0.015525193,0.03448381,0.027469309,-0.0040912335,-0.026478136,-0.046480153,0.10021796,0.0024335394,-0.059646185,-0.02740219,0.040874902,0.054441553,-0.050172105,0.035434693,-0.034828976,0.04107131,0.10226125,0.037254572,0.0031574643,0.00056981394,-0.03577406,0.029393548,-0.095255084,-0.034693643,0.012890096,0.0030966504,0.061692804,-0.005752117,0.020286312,-0.10948941,-0.07698045,-0.046571765,-0.10373987,-0.09290488,0.033896014,0.028131887,0.06665173,0.06645025,0.011362526 +1.3.1.42,"The enzyme catalyses the reduction of (9S,13S,15Z)-12-oxophyto-10,15-dienoate during the biosynthesis of jasmonate from alpha-linolenate in Zea mays.",384,1.0,-0.06009609,0.0861069,-0.06427067,-0.05075676,0.12626478,0.048446827,-0.020399146,-0.014544676,-0.0032225868,-0.0009219318,0.04409675,0.016682168,-0.022335827,-0.05340988,-0.028486468,0.0382714,-0.005806317,0.065050825,-0.07390509,-0.021210395,0.054458182,-0.060564075,0.0029153351,-0.024114292,0.07582258,-0.036775347,0.0349776,-0.03729219,-0.033126533,-0.080845065,-0.028123768,0.010958167,0.005561592,-0.10008222,-0.0218227,-0.021377167,-0.02152222,-0.09706555,0.024176843,-0.006659359,0.013323341,0.041433066,-0.030177988,-0.024167331,-0.011971509,-0.0138722025,-0.04429257,-0.013361726,-0.015512523,-0.020381467,-0.06318368,-0.060557958,-0.067225195,0.008912969,0.050933022,0.007511921,-0.008193321,-0.020862546,-0.049376752,0.07879979,0.0403078,-0.0037589357,-0.05377282,-0.02037141,-0.021955082,-0.0632472,0.064945996,-0.031770308,-0.0023150223,-0.07439229,-0.04210142,-0.041775785,0.014489967,-0.0074710385,-0.085870266,0.08077792,0.044857457,0.009094332,0.031768553,0.014582057,0.002679713,0.041048925,0.015472921,0.021428293,-0.020940192,-0.016808683,-0.029915923,-0.0077461805,0.09313635,0.1305427,0.031592757,0.018481154,0.020576533,0.026396466,-0.076159224,0.062003415,0.09115364,-0.03496121,-0.0019945079,0.004916677,0.08137619,0.0886183,0.03393087,-0.075164795,-0.12963258,0.022391252,-0.021039758,0.0024747723,-0.0071394686,0.063478515,0.015323075,-0.053124513,0.0051208204,0.017725516,-0.037343368,0.033244364,0.063915275,-0.04462051,-0.08172654,-0.0045222538,0.036426023,-0.02528112,0.048409052,0.016998356,-0.042315934,0.097288795,-0.1045731,1.4276709e-33,0.09787305,0.03666879,-0.043524086,0.014731694,0.012264682,0.0015892533,-0.08489804,0.08222703,-0.04086535,-0.04282275,-0.098181866,-0.10603849,0.0087359445,-0.10553586,-0.05678364,-0.027533175,0.037018564,-0.055362787,0.0050760396,0.043643203,-0.05116932,0.0084591685,-0.06500139,0.014562534,0.015344566,0.08061369,-0.031983234,-0.028590288,-0.016581926,0.019517848,0.052553546,-0.031555124,-0.11527452,0.033467863,0.10662651,0.013736371,0.054723524,-0.011485321,-0.025327846,-0.02531246,0.0051249126,0.030962003,-0.0074926494,0.04064931,0.08808499,-0.009777302,0.013744099,0.07179448,0.17268118,-0.00060962,-0.060301345,0.024990669,0.060636625,0.031944145,-0.01804863,0.11760351,-0.010514967,0.008765776,-0.0010380775,0.02592461,-0.048481207,0.039527625,0.023076508,0.060575213,-0.009152392,0.008266845,-0.091394186,-0.06984535,0.027799299,0.044079587,-0.024086703,-0.028548969,0.058069535,0.034333177,0.062073268,-0.068592295,0.060044233,0.0013997873,-0.018702134,-0.0011108108,0.09645112,0.042558644,0.0013958603,-0.06549007,-0.0019114551,0.01188532,-0.066432126,0.03217047,0.015268348,0.019310819,0.0902076,-0.013790494,0.011693286,-0.026750969,-0.079098016,-1.808024e-33,0.047833778,-0.058323424,-0.036765825,-0.02980114,-0.026232315,0.0046982565,-0.041246243,-0.07146254,-0.059480704,-0.021740623,0.031024596,-0.03296305,0.08523025,-0.031067926,0.011453658,-0.020079713,0.053423844,0.11355061,-0.006025462,0.0005159201,0.0040725386,0.037469544,-0.009333555,-0.041929875,0.04915143,0.00818162,0.036108285,0.02077573,0.046215825,0.025351629,0.05501127,-0.07363338,-0.04090187,-0.07746448,0.01538575,-0.009788998,0.0045953076,0.07099516,-0.01501872,0.059548486,-0.059452746,-0.010640712,0.02593621,-0.030638617,-0.001274806,0.019563422,-0.12560569,-0.0046032765,0.06814963,0.012657061,0.07562585,-0.013014668,-0.0734842,0.05528006,0.024785765,-0.010203041,0.047963858,0.037854787,0.0044716652,-0.029248638,0.021085558,-0.044062726,0.04418502,-0.04294384,0.06871241,0.084127985,0.03463578,0.094533846,-0.00018121068,-0.018845852,0.011246405,0.030324979,0.010277771,0.01525663,-0.0028627173,-0.025389845,-0.021179391,-0.046273023,0.009497157,-0.06391676,0.010415069,0.025458986,0.01836269,-0.12020608,-0.09369211,-0.09087143,0.028045882,0.091795936,0.010746922,0.057791717,0.014850749,-0.018541202,-0.024907393,0.03464965,-0.0076360796,-3.159765e-08,0.0064416258,-0.11555879,-0.011583956,-0.01262211,-0.002673937,-0.004449245,-0.015053613,-0.018323252,0.114404626,-0.040071074,0.058591917,0.10210119,0.037203625,0.0730681,0.065713674,-0.097018525,0.022748789,0.06604612,-0.04729309,0.067543864,-0.017827576,0.036620725,-0.06367902,-0.029616605,0.082544394,-0.102884926,-0.023599926,0.0527496,0.061341338,-0.025969684,-0.06964525,0.032291695,0.06247872,-0.08700597,-0.14977543,0.01810799,0.044680025,-0.050217275,-0.0029389712,0.008224695,-0.019745931,-0.08117966,-0.029631915,0.029944161,-0.04299408,-0.06845342,0.042843245,0.0022997037,-0.020164205,0.04951892,0.00065640145,-0.003925559,0.033951998,-0.043146115,-0.052089956,-0.035395455,0.06360689,-0.02087019,-0.013419344,-0.003278347,-0.036739357,-0.007721621,0.12505755,-0.029867511 +1.3.1.43,"Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NAD+-specific enzymes have been reported from some bacteria [2] and plants [3]. Some enzymes also possess the activity of EC 1.3.1.12, prephenate dehydrogenase.",384,1.0,-0.10077912,-0.019965122,-0.054705776,-0.07199536,0.042715695,0.07614867,-0.085960336,-0.019841976,-0.0042538466,0.022606006,0.018168855,-0.027503323,-0.09960872,-0.013470318,-0.0074655702,-0.0042196666,-0.04428834,-0.01903831,0.07627444,-0.030825391,0.024108686,0.027855264,-0.04492013,-0.019000372,0.09540671,0.004275822,-0.00766598,0.03971725,-0.043540195,-0.050426293,-0.028837183,-0.013488593,0.04320551,-0.06087499,-0.024249401,0.0841265,-0.09500504,-0.067889504,0.048326805,0.06513437,0.035986047,0.01350711,-0.04803083,-0.035100967,-0.0480246,-0.058918282,0.03486476,0.08072526,-0.013299975,-0.05105605,-0.036257893,0.02184104,0.07271229,-0.005634647,0.010916242,-0.04695752,0.0018683946,0.035428993,-0.065879226,-0.05378787,-0.011479332,-0.10007291,0.0023985808,0.0012005351,-0.024416521,-0.012865706,0.08929922,-0.0534637,0.0020558685,-0.029749736,-0.114158995,-0.01369475,-0.00022472847,0.050638672,-0.040139258,0.103281856,-0.047936115,-0.035001304,0.050753426,-0.07839835,0.027530262,0.021536168,-0.041207477,0.008055372,0.082201995,0.0047858125,-0.01560883,-0.0027517974,-0.025227942,0.0380978,0.05179668,-0.034781072,-0.0067674643,0.05307256,-0.118428335,0.07456775,0.047634773,0.047749117,0.02552238,-0.111546054,0.013978658,0.1301106,-0.052922234,0.01734481,0.0005326394,0.05332002,-0.007216211,0.07204757,-0.07050123,0.015690219,-0.0012280317,-0.06078101,0.02772193,-0.029316736,-0.028572436,0.08677992,0.036443986,-0.098488726,-0.042616792,-0.050569862,0.03858534,-0.061590362,0.07303433,0.043215442,-0.00943181,0.04894819,-0.122239046,-2.9527217e-34,0.08405654,-1.9599167e-05,-0.031478975,0.0018211093,0.02995062,0.04146674,-0.09803246,0.10710037,-0.023811366,-0.06208955,-0.058361087,0.0034239257,0.0702351,-0.029605204,-0.014698879,0.051843442,0.021474423,-0.037453864,0.009654692,0.047004428,0.008566276,0.0036353818,-0.045648765,0.028313283,0.03331532,0.038597573,0.003798913,0.02387927,-0.0013374235,-0.010260705,0.06698086,-0.15499553,-0.06912281,0.0039780536,0.0587268,0.0055839904,-0.028493915,0.0060937246,-0.009150527,0.06625634,-0.03143602,0.08407943,0.05852698,-0.088585034,0.014856545,-0.06485352,-0.029937332,0.09048058,0.032712873,0.09401735,0.032544658,-0.009994592,0.100276165,-0.09053137,-0.01960045,0.067418724,-0.01096788,0.05672642,0.02765936,0.09224443,-0.009175266,0.03752287,-0.02067792,0.049447175,-0.051730398,0.02226816,-0.062143575,-0.049906105,0.038917873,0.053445697,-0.06703431,0.010087381,0.06404365,0.0021601724,0.03721091,0.0020957666,-0.02660543,0.00486254,0.036801625,0.016693948,-0.031342186,-0.023365274,0.0035566941,0.01521104,-0.039596368,0.039383475,-0.017879354,0.02763136,0.05677572,0.052112587,0.07271119,-0.030633088,-0.03840974,-0.033001836,0.042702436,-1.2245528e-33,0.0731257,0.012561861,-0.0035322213,-0.1285515,-0.060075574,0.18641521,0.06641125,-0.118133925,-0.014134231,-0.07486983,0.084627755,0.05208619,0.018723706,-0.033858802,0.038621183,-0.0489078,-0.081618935,0.03360964,-0.028714957,0.008191944,0.0005579816,0.07791782,0.085921876,-0.030151093,0.03678986,-0.05890454,-0.05512833,0.06667329,0.006870417,-0.0005247566,-0.028245933,0.032732908,-0.034360625,0.004999292,-0.006376864,-0.00059526943,-0.047257826,-0.007400166,0.027255585,0.0348635,0.027840426,0.0016869468,-0.03974903,0.063653246,0.040006056,0.0592557,-0.12991144,-0.012931624,-0.004389765,-0.03569211,0.011568915,0.02059404,-0.041508935,0.013185356,0.05732251,-0.014992683,-0.0005286933,0.059074774,0.05894515,0.023793368,-0.026222082,-0.006767856,0.031167185,0.0072624832,-0.01034652,0.011106599,-0.031728465,0.03771909,0.031450473,-0.01577549,0.0568626,0.015890975,-0.0247108,0.010775007,-0.023556156,-0.030807668,-0.06103574,0.0027726532,-0.009561537,-0.022099765,0.0030857532,0.027541494,-0.047878847,-0.037833463,-0.0026625295,-0.0043310462,0.01856281,0.029144915,-0.06279438,0.03757096,-0.052758455,0.06059811,-0.07513773,0.013422486,0.008684724,-4.015972e-08,0.021543315,0.01248268,0.08989584,-0.03351699,0.054972444,0.005324428,-0.0027401005,0.034956995,0.04534094,-0.0031612338,0.010151831,0.105064705,0.061488472,0.017874215,0.037906475,-0.029516656,-0.025335588,-0.016538743,-0.032345686,0.024765354,-0.036463235,0.032858614,-0.14754586,0.048428733,0.061948705,-0.04610764,-0.0076179444,-0.055139188,0.07497892,-0.03692241,0.019251544,0.016398689,0.0966867,-0.051232047,-0.0064262226,-0.006006375,-0.06028099,0.021241788,-0.081804045,0.05227114,-0.009426735,-0.12615918,-0.08523545,-0.017220058,0.025001286,0.045329098,0.013172157,-0.017212126,-0.054143064,-0.020977775,0.039132964,-0.035592914,0.07832572,-0.07434468,-0.08271927,0.018950256,0.0007478671,-0.10900301,-0.013793733,-0.012359956,0.05391683,-0.020032058,0.097578004,0.009189201 +1.3.1.44,"The enzyme from Euglena gracilis acts on crotonoyl-CoA and, more slowly, on trans-hex-2-enoyl-CoA and trans-oct-2-enoyl-CoA.",384,1.0,-0.065439634,-0.077362485,-0.039032985,-0.039940808,-0.045572348,0.0069115474,-0.030829431,-0.009207392,-0.018087974,0.023142725,0.032246552,-0.09898682,-0.054841194,0.06564095,-0.0043632886,0.026632087,-0.045664486,-0.085373916,-0.0010495362,-0.015513573,0.040917136,-0.044888977,-0.04519256,0.03332869,0.036192264,0.0400096,0.017373443,-0.023074264,0.035068665,-0.08779085,-0.053151187,-0.021447197,0.024635721,0.01767927,-0.015095541,0.06717007,-0.039899692,-0.08389555,0.021888683,0.021580324,0.07614564,-0.035922356,-0.09938394,-0.020755218,-0.038851004,-0.08372151,0.03936425,-0.013160734,-0.039343353,0.030584417,0.016788715,-0.0868364,-0.073628835,-0.012625146,0.031059619,0.07140633,-0.00898445,0.028673446,0.032676376,0.0008166221,0.016362524,-0.030018272,-0.02113338,0.006421641,0.00035976546,-0.03457021,0.018798294,-0.03320001,-0.006268303,-0.032635,-0.020138953,-0.09025743,-0.024850365,0.09142706,0.005764718,-0.06207012,-0.0113101965,-0.046526328,0.025642432,-0.015566454,-0.04783711,0.027441552,0.009965669,0.07029372,0.036035813,0.069143154,0.03765788,-0.0039410004,0.030718315,0.016397927,0.112033315,-0.019713167,-0.012578157,0.0018520227,-0.03428947,0.10124558,0.013396513,-0.013873054,-0.0048034885,-0.038067356,0.05698005,0.06307509,-0.0351511,-0.009981839,-0.062547624,-0.008536724,0.034313295,0.08896523,-0.031334214,-0.022005195,-0.05917439,-0.03224359,0.051539566,-0.019436007,-0.058615305,0.09956083,-0.006910378,0.015233998,0.054072812,0.020942148,0.007867622,0.013568603,0.016917692,0.04915995,0.03280533,0.07519704,-0.04599501,-7.32697e-34,-0.0020789143,-0.0066706105,-0.0136168385,0.050277386,-0.005210065,-0.016197171,-0.099179894,0.050244197,-0.050403688,-0.07536447,-0.05131193,0.03697759,0.02523266,0.050081797,-0.00046870322,-0.00885829,0.018597443,-0.017350797,0.02841036,0.05021471,0.0782197,-0.014825874,-0.02908513,-0.007418893,-0.08030975,0.013562242,-0.049746674,0.08828433,0.058534417,0.014509145,0.0028541351,-0.07051657,-0.01868496,0.03363513,0.0575959,0.013377655,0.022242619,0.000990378,-0.018241927,0.07893004,0.085971415,0.041123874,-0.037834495,-0.064756595,0.06538799,-0.08469933,-0.045925267,0.09028903,0.036387928,-0.0019961307,0.1429979,-0.009103302,0.0636,0.017268214,-0.031445097,0.14123745,0.014249963,-0.027811928,0.1050082,-0.002615159,-0.017996384,0.017830713,0.075703695,0.0021180094,0.104598254,0.0582904,-0.07556084,-0.06741596,-0.09032332,0.051192787,-0.06859136,0.0036848756,0.05241347,0.0063416627,0.06389822,-0.046090927,-0.060470458,0.0060030967,-0.038705166,0.032232918,0.023499595,-0.02623555,0.059636626,-0.022209724,-0.0015350202,-0.0538766,0.047584686,-0.057818115,-0.04945935,0.10565274,0.09829713,-0.015796488,-0.053272393,-0.0643395,0.04974066,4.403197e-34,0.07849023,-0.11662601,0.03911202,-0.087710425,-0.042322204,0.08447882,0.031816296,-0.07806428,0.07350723,0.054400273,0.17135698,0.05893989,-0.04339716,-0.03211752,0.0058987276,0.056367386,0.04268245,0.054857813,-0.009553826,-0.09045987,-0.023823189,0.045564774,0.009038988,0.0031841795,0.065645665,-0.009012484,0.010733518,0.050649676,0.011817293,-0.024021864,-0.034596093,-0.057867456,-0.03349129,0.02783479,-0.05767031,0.045826904,-0.044732925,0.056922264,0.011625415,-0.0697888,0.0031090358,0.0043967282,0.06304098,0.061644066,0.010772334,0.018794032,-0.07291486,0.026413051,-0.08409281,0.036286872,0.051588736,0.022067763,-0.034118824,0.012110107,0.05686665,0.01651076,0.03182978,-0.04254895,-0.025326932,-0.0122055095,-0.05504406,0.0077522225,-0.021921,0.009490322,0.093538806,0.007626347,-0.06337745,0.054276694,0.007504429,-0.019650266,0.07077031,-0.00098982,-0.0027981263,-0.011323478,-0.04914373,0.0006809419,-0.042199526,-0.009891978,-0.0046195136,-0.074405596,-0.015055874,-0.00658667,-0.014191826,-0.051137745,-0.122793496,-0.07092077,-0.040958505,0.08038726,0.046794023,0.06627853,-0.057805683,-0.03814993,0.014999848,0.021026444,0.15106474,-3.4296285e-08,-0.05611262,-0.096563175,0.012371132,-0.015679916,0.020305905,0.058731224,-0.07797973,-0.017152773,0.08155869,-0.057211272,-0.009725533,0.030802783,0.05588463,0.059536528,-0.010911495,0.05820138,0.04210739,0.03292067,-0.006473521,-0.07118646,-0.0881035,0.015959833,-0.0430598,0.06310325,-0.011508834,-0.06668054,0.012882489,0.086076535,-0.024848387,-0.043747053,-0.024220044,-0.020607721,0.021202432,-0.032098353,-0.06961813,0.04276463,0.026146106,-0.0075611803,-0.05671547,0.07925513,0.060399473,-0.048752487,-0.056761548,-0.042253584,-0.039925337,0.026598645,0.02954521,0.010056374,0.021554893,-0.009963284,0.04964464,0.025456702,0.0075628045,-0.07055934,-0.12654424,0.020337816,-0.047054663,-0.085439846,0.004747117,-0.014660768,-0.032176565,0.08723662,0.12925477,-0.0061147986 +1.3.1.45,"In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.",384,1.0,-0.008434609,0.0005070481,-0.09992905,0.0640056,-0.04158132,0.051834937,-0.09230884,0.025094658,0.018374892,-0.06520681,0.03399183,-0.035368674,-0.08520088,-0.08008047,-0.085482195,0.054077446,-0.092140965,0.037697885,0.018336168,-0.017000685,-0.009494819,-0.06532904,0.0158441,0.016953198,-0.03474894,0.033669062,-0.007230128,0.0289941,-0.017230595,-0.010935074,0.040993046,-0.013852622,0.0145288315,-0.03409828,-0.055838138,0.07123569,-0.06088018,-0.0025325292,0.12090558,-0.0088696405,0.10713441,-0.032234374,0.017683553,-0.00864907,0.06941548,-0.027546154,-0.0467914,0.017070074,0.07577138,0.04156391,-0.05348226,-0.010743736,-0.059079487,0.059440553,0.06807748,-0.014688286,0.052102044,0.051172398,0.035344884,0.03349395,0.023947064,-0.028183734,-0.011466197,-0.0042246548,0.030200336,-0.05076188,-0.083764106,-0.060085427,0.03946641,-0.04964763,0.008123981,-0.01237272,0.055069666,0.017944736,0.022306941,0.09177129,-0.10952205,0.04020334,-0.04302414,-0.013781693,0.06971321,-0.03479732,0.014321419,0.11916659,-0.017485382,-0.04604734,-0.02536538,-0.04713205,0.022404192,0.04366292,0.06683509,0.07293054,0.04441641,0.012362483,0.0059694164,0.029269854,0.02451778,-0.012299677,-0.07319617,0.0179737,-0.040307734,-0.0259537,-0.13347597,-0.086856134,0.01692983,0.04133281,-0.041057102,0.003872069,0.053579032,0.014208302,-0.030321663,-0.036952607,-0.010555607,-0.042848147,0.010183386,0.038700838,0.02443366,0.026171051,0.035148863,-0.008514312,-0.014312951,0.027795902,0.045091476,0.01370453,-0.046534356,-0.03857282,-0.022773722,4.0047994e-33,0.045332227,0.054077625,-0.028169662,-0.0084370645,0.0659791,-0.018285643,-0.024608893,-0.081810735,0.075190336,-0.056027845,-0.10115182,-0.016831439,-0.056021437,0.038541153,-0.07748584,-0.10825726,-0.038270593,0.03469325,0.06810312,-0.052774474,5.0641986e-05,0.046066444,-0.09058003,0.005941079,-0.0403827,0.047759004,-0.04291826,-0.019793306,-6.561079e-05,0.0057689804,-0.042037446,-0.019969633,-0.07499097,-0.04054408,0.011992982,-0.027276022,-0.024305245,-0.083164416,-0.117420144,0.03494298,-0.06645608,-0.031121964,-0.057918996,-0.05574593,0.087241955,-0.022956664,-0.023137553,0.07211778,0.035715327,-0.0074483915,0.024158664,-0.043788627,0.09083866,0.02088501,-0.06316669,-0.028146874,0.04877027,0.013965382,0.05431598,0.07834193,0.05368391,0.04082355,0.010908634,0.0020454568,-0.06402392,0.019851541,-0.020147027,-0.049055252,-0.0248963,0.055645946,-0.016928826,0.023453716,0.009623961,0.035200905,0.022732897,-0.019415895,-0.040779658,-0.0070334277,-0.027809907,-0.04158364,-0.07434485,0.010355401,0.05046421,0.023716332,-0.011471433,0.024652006,-0.044478677,-0.029426835,0.03142437,0.008123993,0.012047781,0.0031644395,-0.075004645,0.03337062,0.087001085,-4.8522713e-33,-0.014226082,-0.028735356,-0.04276165,-0.03376002,-0.07308453,0.0138366185,-0.07493618,0.01855246,0.0073736175,-0.0043469467,0.040801328,-0.075600214,0.002225981,0.013621539,-0.030017223,0.05187004,0.05471354,0.086097345,-0.033428106,-0.051350094,-0.02691087,0.022553543,0.0027381708,0.13873525,0.08162753,-0.008508694,0.12270678,0.059296884,0.063090615,0.06391932,-0.011772385,0.01949876,-0.023235451,0.034254625,-0.0022471624,0.12927619,-0.061085332,0.027218154,0.023599656,0.04647302,0.061172497,-0.030997744,-0.0061298846,0.036454365,0.019830348,0.013136558,-0.046680976,0.041906863,0.007053959,-0.07239534,0.024770986,0.0078020627,0.020940036,0.04079234,0.02404195,0.016432304,0.044526685,-0.045727726,0.09275536,-0.05555461,-0.022432067,-0.06304137,-0.0033716494,-0.0022536928,0.03909578,0.06929294,0.04372945,0.022669053,0.03366231,0.013701027,0.15005973,-0.00081598706,0.058567975,0.06803002,-0.008725469,0.02893923,0.016930146,-0.02259872,0.006088521,-0.0127719315,0.013088088,0.005696382,0.088855416,-0.10883158,-0.08902247,-0.040899433,-0.012477509,0.07146417,-0.07291819,0.08722557,0.0436801,0.041320536,-0.051690698,-0.03727923,0.029523563,-3.8069782e-08,0.062054947,-0.023772532,0.037867296,0.043631252,0.018176999,0.014877866,-0.0820285,0.046066042,0.018621374,-0.07075324,-0.062269896,0.02086378,0.004191922,0.03432815,0.013251162,0.0677685,-0.02255758,0.03311621,-0.008944979,0.0624866,-0.13856,-0.010203003,-0.06503132,-0.020132743,-0.058159415,-0.066228874,0.032664612,0.035391565,0.08311234,0.005549059,0.070298456,-0.012192414,-0.032740843,-0.040277902,-0.14533,0.08946794,-0.016311219,-0.0772572,-0.0018925614,-0.0049979617,-0.09726932,-0.051514354,-0.038151566,-0.015383179,-0.0053705117,-0.017765695,0.028854212,0.056267954,-0.048428666,-0.06978782,0.024061427,-0.025554303,0.040874187,-0.0479872,-0.061874762,0.017142938,-0.012339285,0.034927994,-0.037385706,-0.04796142,-0.090922974,0.030749012,0.20151283,0.002085071 +1.3.1.46,Some other isoflavones are reduced to the corresponding isoflavanones.,384,1.0,0.0078640925,-0.03873309,-0.048380673,0.07626712,-0.035959046,0.060861077,-0.028850833,-0.016988285,0.041416276,-0.072746105,0.055927116,-0.0399834,-0.01953692,-0.040856645,-0.035390716,-0.03488751,-0.0046161455,0.080075465,-0.091596015,-0.030573212,-0.010031998,-0.10155116,0.03142806,-0.001785644,0.029294353,0.02680388,-0.035846137,-0.0076979822,0.017457655,-0.07486991,0.04196445,-0.008082562,0.058618974,-0.047772523,-0.0046009393,0.024427913,-0.06305423,0.057307355,0.077861115,0.014279838,0.032092154,-0.049888235,0.032019418,-0.01366179,0.04202534,0.0034056988,-0.030008895,0.034630273,0.012214182,0.0011609464,-0.02875082,-0.03925138,-0.07999881,0.09956607,0.0513342,-0.06263678,-0.016224805,0.0030599623,-0.06873255,0.050857328,-0.009446069,-0.047479138,-0.018995069,-0.0076417327,-0.030544087,-0.021023547,0.005855287,-0.019976854,0.025269184,0.0090141,0.03242662,0.014352287,-0.07145474,0.034783375,-0.036895636,0.11094266,-0.019288914,0.023279265,-0.05898562,0.0066070016,0.07821269,-0.012189611,0.039729342,0.052951913,-0.05348622,-0.07223763,-0.04102751,-0.050435714,-0.040457733,0.0687313,0.018377393,0.08609481,0.06165663,0.005896676,-0.013163774,-0.0012452591,0.028100612,0.08806366,-0.06492997,0.010214221,-0.06531892,-0.06347828,-0.11936751,-0.07302169,-0.058064166,0.033786114,-0.0450805,-0.04590363,0.0019350556,0.008620461,-0.052284393,-0.0303464,-0.04248207,-0.02006716,-0.0036379949,0.03217744,0.098441236,0.013591351,-0.0045045633,0.02422027,-0.07518374,0.059961535,0.1314628,0.044876475,-0.04743944,-0.012515821,0.013699085,-9.759824e-35,0.027458176,0.036241937,-0.02310993,-0.015569873,0.038448207,0.0020545106,-0.0046685217,-0.014425272,0.06778435,-0.055201452,-0.15798885,0.0584017,-0.055530827,0.007708674,-0.032267343,-0.008828103,-2.4235194e-05,0.0016366852,0.038566284,-0.08386381,0.0067509515,0.061371453,-0.05135407,-0.009304832,-0.043111358,-0.020129588,-0.03234359,-0.0026901958,-0.059313525,-0.016985003,-0.059447184,0.009366152,-0.026499348,0.00053607934,0.013337029,0.018393386,-0.04186513,-0.03633397,-0.13188523,0.05681133,-0.03059829,-0.018766055,-0.060447246,-0.06929607,0.096031174,-0.0020503243,-0.047138367,0.0079111075,0.05422278,0.057955984,0.028221874,0.0052988967,0.055917468,0.015848428,-0.056597102,-0.016288526,0.04045229,0.011406678,0.048044905,0.033257622,-0.0323836,0.032072186,-0.01808671,-7.458557e-05,-0.037706602,0.05813156,-0.07303698,-0.04535112,-0.044361167,0.02729607,-0.0004175222,-0.03740125,0.08204288,0.032837257,0.08797786,-0.023723103,-0.08548782,-0.051699087,0.013472968,-0.0057779574,-0.07566241,0.00031273448,0.018047078,-0.022838276,-0.052886046,0.011055762,-0.008108174,0.016791796,0.09139362,-0.06185559,-0.0014545076,-0.005725381,-0.07741246,0.01672619,0.087754376,-1.2156643e-33,-0.0012715788,-0.07603699,-0.058755986,0.0076553863,-0.02079406,0.07266228,0.014940309,-0.039998155,-0.032598864,0.037251733,0.031480096,-0.12148425,-0.038803276,-0.019362092,-0.07692041,-0.02972527,0.036382116,0.08426377,-0.046273522,0.019711807,-0.0626745,0.06702324,-0.03268876,0.11930359,0.05738596,-3.0636647e-06,0.12648736,0.056277774,0.051190436,0.07103312,-0.0035543672,0.0041668736,-0.05503478,-0.012902324,0.036921613,0.035919648,-0.022798019,0.050486892,-0.06122856,-0.0029323513,-0.0683063,-0.021538673,-0.010384938,0.050657894,0.07991412,0.036753893,-0.022190277,-0.030360585,-0.030894995,-0.07788845,0.033889532,0.018006383,-0.00802758,0.0959945,0.069179974,0.03645435,-0.014236714,0.034211773,0.101461865,-0.021991977,0.007701465,-0.06875311,0.034089424,-0.01387079,0.0893306,0.08499186,0.030261206,0.07526509,-0.034774505,0.008481556,0.07643676,-0.084908195,0.060137916,0.042489856,0.050357375,-0.0015653825,0.03365537,-0.02898744,-0.094540834,-0.032745615,0.0053437767,-0.072787575,-0.035326853,-0.08860881,-0.08928061,-0.022363931,-0.015118679,-0.01698966,-0.014077114,0.1203726,0.022216253,0.07315595,0.0073095397,0.03900263,0.05515369,-2.0090347e-08,0.07305199,0.0028640833,0.046895266,0.06771525,0.040584154,-0.013762069,-0.06871512,0.06330033,0.00073080877,-0.025731549,-0.008579518,0.06521438,0.052753106,0.07339757,0.073022656,-0.02190743,0.00093141745,0.04545196,0.009677261,0.062407844,-0.11393831,0.030580591,-0.03728685,-0.10765849,0.010792458,-0.08270126,0.053377982,0.038760018,0.09788348,-0.00080292975,0.08652166,-0.02058985,0.060656853,-0.052963957,-0.066588305,0.106554724,0.06851821,-0.032157928,-0.05292882,0.040827375,-0.10502196,-0.071662,-0.040558886,0.00806724,0.059887588,-0.0059056277,0.025400532,0.030563049,-0.03952183,5.6813347e-05,-0.032009587,0.017012347,-0.02316928,-0.029256852,-0.03602847,0.0091100335,-0.008572077,0.023546811,0.0042575905,-0.07254924,-0.063562885,-0.030024994,0.1406571,0.037022807 +1.3.1.48,"Reduces 13,14-dehydro-15-oxoprostaglandins to 13,14-dihydro derivatives. The enzyme from placenta is specific for NAD+.",384,1.0,-0.050560556,0.06492813,-0.049237523,-0.06447779,0.13557594,-0.022486988,-0.044713475,0.089849815,0.041774984,-0.0016974965,0.020466374,0.009891328,-0.163762,0.03386942,-0.034570143,0.062351953,-0.048890803,0.046241865,0.004389456,-0.036987733,-0.015878534,-0.045015782,0.10857151,0.02980674,0.060183834,0.04166168,-0.018966725,0.08011636,-0.012294801,-0.022965366,0.0067159925,0.0018251837,0.024621766,-0.07599576,-0.035689097,0.06923833,-0.029908793,-0.012417894,-0.016697424,0.03353896,0.042054214,0.012008406,-0.035063986,0.04776823,-0.05801246,-0.08923915,-0.023882592,0.07931869,0.053274564,0.09803236,-0.020163057,-0.043295525,-0.014998652,0.06752738,0.053113163,-0.002346283,-0.050780546,-0.062343795,-0.017393304,-0.013909517,0.016435433,-0.07953057,-0.07354795,0.0006900543,-0.027462723,-0.01911179,0.10336024,-0.04061143,-0.042842463,0.0016608204,-0.014029446,0.003256927,0.12219945,0.032362416,-0.00043548044,0.12793645,-0.059847075,-0.051610246,0.014410537,-0.04251545,0.019303853,0.035819605,-0.0140919145,0.11944179,0.020966895,0.0052549504,-0.022082785,-0.026220068,-0.028932907,-0.008529558,0.031262502,-0.004969682,-0.018991718,0.03826589,-0.1375026,0.03809919,0.066644505,-0.00420713,-0.031516366,0.05170645,0.012169229,0.06851452,-0.042736,-0.07078917,-0.07778845,0.023724716,-0.0698605,0.061464604,-0.039677385,-0.014988554,-0.02030573,-0.022995297,0.027893733,0.021391945,-0.060937557,0.08193266,0.04531823,-0.032709386,-0.017379805,-0.039206106,0.017137898,0.017989218,0.00034821496,0.026673337,-0.033737157,0.018364998,-0.091508806,7.1820032e-34,0.112646244,0.023690272,0.0012849148,0.03410554,0.008354431,0.0440878,-0.07987613,-0.014209615,0.017411362,0.008968709,-0.05041149,-0.1208329,0.008905709,-0.07799845,-0.00043516935,-0.018343452,0.0139976125,-0.07279963,0.029883606,0.048196577,0.07504709,0.06434677,-0.09338743,-0.032009516,0.07196273,0.04342379,-0.05956855,0.06848582,0.010935383,-0.0062595755,0.014102154,-0.065736584,-0.099967375,0.0076046973,-0.0044259955,-0.009038408,-0.050655086,-0.08040233,0.042306177,0.028116541,-0.08486774,-0.021356469,-0.022855183,-0.024901837,0.109000556,-0.039988644,0.030508772,0.040462054,0.03692332,0.045187086,0.06135759,-0.05750788,0.021343062,-0.045455612,-0.112076424,0.023164494,-0.080697864,-0.04004015,0.049668897,0.05510611,0.052836087,-0.06049889,0.06785015,0.003658657,-0.016195169,-0.092192166,0.01831285,-0.088349216,-0.059308056,0.053292315,-0.04010188,0.060149383,0.05294658,-0.029273273,0.038410794,-0.010023598,0.01879278,0.0982077,0.047299042,-0.014094661,0.02187855,-0.018409539,-0.047320265,0.015831906,0.016733645,0.0035955482,-0.055555608,-0.0039624185,0.0238205,0.018761814,0.010218413,-0.09833433,-0.047460146,-0.07988576,0.0011018863,-8.2897395e-34,0.031025695,-0.041519545,0.022228379,-0.06924232,-0.08291384,0.07016731,0.030173551,0.019745603,-0.001859825,-0.06250695,0.05534837,0.03612586,-0.026310185,-0.09795578,0.05416524,0.052073576,-0.02318946,0.050077524,-0.017220546,-0.00011484333,0.0058189738,0.06796428,-0.021884969,0.018667677,0.10830621,-0.059276722,0.011730777,0.040321894,0.05715099,0.027533047,-0.024436729,0.017997136,-0.043150965,-0.03445785,0.035453957,0.005335015,-0.06235203,-0.014637757,-0.017715631,0.033887655,-0.023657314,-0.048171114,-0.013464161,0.08186904,-0.027296083,0.08328969,-0.12085569,-0.021146286,0.07547702,-0.0025278304,0.015458372,0.025847498,-0.10950469,0.02776839,0.055350654,0.014309722,0.05401362,-0.069371894,0.065640315,0.011185072,-0.019358493,-0.01891564,0.00088791,-0.011912444,0.010941659,0.064063154,-0.06508262,0.04440983,0.022203417,0.06487913,0.062474363,0.017759081,0.016240498,0.015868755,0.011400307,-0.10918101,0.027388431,-0.018610429,-0.027250273,-1.64913e-05,-0.02736605,-0.037395187,-0.026498493,-0.0370886,-0.02065337,-0.009571659,0.08926847,0.08801948,-0.08454779,0.053594287,0.037312333,0.017344475,-0.038226243,0.08960716,-0.032889076,-2.6732955e-08,0.039541326,-0.07788214,0.0029685867,-0.05574616,-0.026240919,-0.028093237,0.042559702,0.067843564,0.0022090026,0.024444392,0.0147986105,0.14889269,0.07597548,0.033262394,-0.034755476,-0.036567207,0.0008800038,0.06767158,-0.035776034,-0.0018034568,0.0052581024,0.023647705,-0.055368446,0.04633087,0.076382965,-0.03660909,0.045883454,0.040432252,0.08025391,-0.040592115,0.06982406,0.00038146108,0.047879048,-0.014226962,-0.043819517,0.059735686,-0.012515332,0.007091859,-0.019127443,0.010458428,-0.037412304,-0.09082056,-0.03232243,-0.002264451,0.0045351014,-0.06607379,0.03998505,0.03373833,0.023893544,0.072855115,0.033336487,0.010248724,0.0070030726,-0.03425413,-0.04929091,-0.004611132,-0.00241933,-0.06509179,-0.013846784,-0.02864442,-0.0072304388,-0.059220806,0.13073623,0.0010775136 +1.3.1.51,"In the reverse reaction, the 2'-hydroxyisoflavone (2'-hydroxydaidzein) is reduced to an isoflavanone. Also acts on 2'-hydroxyformononetin and to a small extent on 2'-hydroxygenistein. Involved in the biosynthesis of the phytoalexin glyceollin. The isoflavones biochanin A, daidzein and genestein as well as the flavonoids apigenin, kaempferol and quercetin do not act as substrates.",384,1.0,-0.037273858,-0.05235731,-0.046215788,0.06300008,0.016940394,0.06634623,-0.055397116,-0.010107366,0.007704834,-0.063340634,0.032239284,-0.0072768424,-0.07016495,-0.048373256,-0.09867122,-0.012654734,-0.06065219,0.06837826,-0.11483397,-0.052133616,0.058152765,-0.053668197,0.0121984035,-0.021687815,0.040263887,-0.0285721,-0.018055482,-0.003797526,0.042215873,-0.044094346,0.04942783,-0.007111471,-0.02657727,0.00047799904,-0.105425864,0.06730823,0.003277408,-0.04258408,0.09131281,-0.031863656,0.06725758,-0.02572787,-0.036546525,-0.02166184,0.055635437,-0.03146874,-0.022364754,-0.015429242,0.028834684,0.060708776,-0.05714594,-0.05272084,-0.039319813,0.059161846,0.044150524,-0.0017799188,0.019236645,0.078725606,-0.018774278,0.079437286,0.0036484948,-0.03928539,0.017027706,0.018521512,-0.040111158,-0.07100149,-0.05678709,-0.01761664,-0.012350914,-0.054613713,-0.0074365134,-0.018041838,-0.019379385,0.019517813,0.054294366,0.11594172,-0.10685809,0.029484836,-0.0569294,-0.02258759,0.07010772,-0.0787905,0.074170545,0.16543809,0.008738215,-0.09504483,-0.05097022,-0.023619704,-0.0014552589,0.09278713,0.034154925,0.08334604,0.07391119,0.0052295653,0.05449618,0.08515645,0.056927454,-0.0024162836,-0.04898328,0.006966659,-0.07191467,-0.015545089,-0.059656505,-0.04480198,-0.0043876567,-0.0011003466,-0.07903495,-0.05174971,0.06410825,-0.042957067,-0.0060868775,-0.013412959,0.014689993,-0.04060988,-0.029242499,0.061334394,0.033117842,0.012355909,-0.012516682,-0.069162995,-0.046655774,0.061601836,0.08078088,0.0401985,-0.061104197,-0.050270937,-0.015156282,5.6112697e-33,0.049368694,0.016243644,-0.029582063,-0.01816194,0.017897742,-0.05658724,-0.03725907,-0.015454085,0.050620716,-0.03737621,-0.07179334,0.014945088,-0.07594877,0.068804316,0.018096177,-0.032846138,-0.02319945,-0.05839348,0.11007861,-0.035873163,0.041733783,0.0011144812,-0.08845977,7.232262e-05,-0.022751566,0.0008284118,-0.028167948,0.026040329,-0.026714073,-0.003691759,-0.024405211,-0.07856435,-0.03203693,-0.015006158,-0.022502197,0.011989753,-0.054578856,-0.06385186,-0.08326513,0.028010305,-0.005436662,-0.013295784,-0.010975477,-0.09185531,0.030548254,0.052930478,-0.031067546,0.034605365,0.11381082,0.0129768215,0.036659814,-0.015992822,0.10673418,0.041340996,-0.0019316999,0.028561767,0.019048525,-0.03315959,0.033619672,0.098366074,0.031390127,0.022714334,0.030920083,0.04543303,-0.033074256,0.06754248,-0.02630657,-0.025024626,-0.038018007,0.040568195,0.024529072,-0.031209495,0.054739136,0.004499441,0.07471776,-0.042547967,0.0012324695,-0.018433671,-0.035560973,-0.013066983,-0.002798488,0.054106925,-0.020654837,0.01711936,-0.08733014,0.016815118,-0.06074396,-0.032781437,0.02738402,0.021240398,0.004094476,-0.02738342,-0.031293772,0.014260188,0.03335862,-6.615565e-33,0.020948721,-0.06306963,-0.0018346728,0.0038177234,-0.041608248,0.045581445,-0.003364226,0.03132536,-0.0060266387,0.01836141,0.04124616,-0.06391976,-0.034743544,0.03475175,-0.0716294,0.017520027,0.037053097,0.051198952,-0.0062101907,0.006477352,-0.04157486,0.045470066,0.014413113,0.09695844,0.09032335,0.019024424,0.069220886,0.038616348,-0.017196937,0.08619807,-0.019057415,0.009409339,-0.012986802,-0.009206601,-0.022762625,0.08340578,-0.04801282,-0.003879825,-0.04633969,-0.0043564625,0.018946214,-0.0063800765,0.012029954,0.053366296,0.075210854,0.03651154,-0.05901204,0.007384518,-0.006893014,-0.054102864,0.017488549,0.11975638,-0.0038143187,0.07114298,0.04261716,0.02831952,0.050296426,0.0046587493,0.091977075,-0.055824403,-0.0018512382,-0.08857862,-0.0032383155,-0.013311998,0.053139642,0.06704342,-0.02232855,0.06128582,0.008023455,0.016304536,0.105802484,-0.086945206,0.08676761,0.043195274,-0.022218408,0.034691256,0.0146468915,0.007974906,-0.044232156,0.022694547,0.04385603,0.011091359,-0.00011755106,-0.12401066,-0.058489,-0.08996524,-0.043736253,0.07620188,-0.021157201,0.07150195,-0.006310463,0.010342189,-0.07043293,-0.029824935,0.052351166,-4.5737327e-08,0.013650262,-0.052937575,0.08039462,-0.0145931095,0.010109623,0.027477367,-0.0573346,0.05513788,-0.037849247,-0.074477315,-0.08531475,0.059923425,-0.0076738857,0.027419606,-0.03254888,0.042419277,-0.055262845,0.04400343,0.006622452,-0.00050326675,-0.12189078,0.016772207,-0.14774159,-0.009387542,-0.021913905,-0.050670628,-0.040395226,0.049846325,0.10340109,0.0003681605,0.06535027,0.014758129,0.019113295,-0.07024975,-0.14738451,0.018689537,-0.020424595,-0.04539997,0.0018966675,-0.04037869,-0.115362704,-0.028347548,0.010981286,0.0155025255,-0.0070908866,0.0069853645,0.060013864,0.055312235,0.007387884,-0.00044912216,0.05282532,-0.05774524,0.047880348,-0.057456013,-0.07703146,-0.02813364,0.0057949745,0.014848675,-0.05667615,-0.050952375,-0.10260497,-0.015337792,0.18445608,0.030466465 +1.3.1.52,A flavoprotein (FAD) from Ascaris suum. The reaction proceeds only in the presence of another flavoprotein ('electron-transferring flavoprotein').,384,1.0,-0.09273471,-0.037125085,-0.1285214,0.0765332,0.10894746,0.017283512,0.017988522,0.058884464,0.05083583,-0.038878858,0.08416583,0.001194047,-0.061716147,-0.05620741,-0.12085812,0.023901546,-0.003266043,0.005249639,-0.09550709,-0.024765354,0.014312339,0.014496898,0.037993204,-0.067135856,0.011430604,0.0022784323,0.012234823,-0.08887596,-0.008920729,-0.06303651,0.048712302,0.042102378,0.027010253,-0.025937814,-0.06929469,0.02978825,-0.011993493,-0.052350495,0.026434198,0.001109016,0.07076339,-0.047866356,0.03311549,-0.018629856,0.032617386,-0.02248271,-0.028870843,0.08822252,0.037331764,0.02910528,-0.011221352,-0.010347216,-0.10955704,0.04848256,-0.052766453,0.06692442,-0.05614879,-0.08290293,0.014833161,0.0022288798,-0.009585434,0.025145963,0.029455388,0.008472367,0.044866752,-0.071477205,-0.062158376,-0.03417126,0.004195907,0.016118648,0.04534932,-0.031231973,-0.026473064,0.043228623,0.047352713,0.04837623,-0.06635854,-0.03284254,0.064339116,-0.0076002087,0.07423992,-0.04878733,0.07186401,0.061812416,0.046819,0.0021111635,0.029910525,0.04221258,-0.04486338,0.05103344,-0.042709988,-0.034495633,-0.008128056,-0.019053036,-0.08415756,0.047211096,0.06945935,-0.02518617,-0.031076293,-0.030419767,-0.07962251,0.01732546,0.025128243,-0.035482086,-0.104755394,-0.053644955,-0.060955014,0.024372203,-0.0012271397,-0.04609016,-0.015471058,-0.09426106,0.013054588,-0.09623828,0.006016156,0.047744907,-0.030389365,-0.04967137,-0.06850175,-0.0405985,0.05310349,0.07977979,0.019304296,0.11042718,0.036261406,0.03913662,-0.08629901,1.9772283e-33,0.056776352,-0.013384485,-0.00292676,0.014934319,0.001958274,-0.025914425,-0.053100687,-0.023318665,0.02075246,-0.0142818475,-0.029150307,-0.026593128,0.015560868,-0.048975013,0.014549769,0.027497048,-0.009938941,-0.07579668,0.09217429,-0.11961714,0.027340302,0.099473864,-0.035730757,0.041503783,-0.0072948984,-0.043270297,-0.047448233,0.036801938,0.028447945,0.013816191,0.049385358,-0.00622999,-0.068819255,0.008390537,0.0076399017,0.05874377,-0.06903462,-0.11629845,-0.097581014,0.060672633,-0.010735532,0.0030045041,-0.038580988,-0.03085279,0.021709146,-0.07004049,-0.06753581,0.053011052,0.045376446,0.0897708,0.032186903,-0.024440916,0.14881012,0.08375032,-0.047530346,-0.004801017,-0.019309217,0.03078146,0.0025391418,0.04448106,2.3657938e-05,0.017654458,-0.048120923,0.08920204,-0.07205251,0.04075289,-0.070743635,-0.045350865,-0.026341474,0.06449315,-0.016105488,-0.0012007925,0.049756244,-0.015581438,0.025503023,0.0062966687,-0.06762833,0.011130834,-0.03762804,0.012936324,-0.062918484,-0.018546777,-0.025727069,-0.007307818,-0.010723124,0.047707707,-0.07311229,-0.06523966,0.0084491335,0.0049560023,0.04294838,-0.047634218,-0.03076166,-0.004113665,0.08797253,-2.2015751e-33,0.008682435,-0.1180827,0.029957522,0.06242212,0.0053480035,0.056290712,0.06352283,-0.022598369,0.023301572,-0.048233878,-0.012989563,-0.0026411794,-0.0018876458,-0.014550609,0.047450542,0.029884515,0.023953782,0.053329818,0.033839513,-0.011863254,-0.03338391,0.045142878,0.083472304,0.08113016,0.062997945,0.0009102419,0.054569136,-0.04870509,-0.015515941,0.05599263,0.002831657,0.023232605,-0.06715531,0.011614313,-0.06311348,0.020618578,0.017827338,0.01720634,-0.031732205,-0.0010280249,-0.043753814,0.0060396194,0.0675454,0.08804573,0.096872166,0.027038077,-0.056800704,0.06519817,0.057793435,-0.051491525,0.027838865,0.03243462,-0.022197513,0.018683378,0.071164764,0.073108904,0.09113009,0.0074731763,0.033340294,-0.058841955,0.013907626,-0.11548375,0.016223012,-0.052830625,0.083667725,0.063531354,0.049486786,0.10093157,0.0061023557,-0.018768815,0.1312571,0.038620252,-0.00970337,0.07149998,0.03098065,-0.021821855,0.004443072,0.033132087,0.017342288,0.00027347342,-0.06049646,-0.009955533,0.021560721,0.012030369,-0.03283338,-0.07527914,-0.005735792,0.04273795,0.036796384,0.008874401,-0.06690867,0.049025863,0.010570574,-0.048377853,0.06250832,-2.7236636e-08,0.015621495,-0.035665184,0.0025115705,-0.027664365,0.08523882,0.025652329,-0.044641003,-0.029697755,0.007906544,-0.051078215,-0.08437048,0.16961826,0.057940792,0.010695549,0.06994259,-0.04809779,0.035908043,0.016379323,-0.017487826,-0.10544604,-0.09054054,0.021742798,-0.039576396,0.049529593,-0.06508753,-0.05022306,0.05816817,-0.0051811174,0.06682503,-0.06582491,0.00576433,-0.0140211675,0.011257148,-0.034163844,-0.06100025,0.031675383,0.027606452,-0.06888586,0.0113558145,0.054382123,-0.057355214,0.01957089,0.025223173,-0.01500147,-0.046680503,0.016831076,0.027194979,-0.033529334,-0.07079774,-0.0029060512,0.013197508,-0.06496156,-0.012527571,0.015032545,-0.057410732,-0.026135378,0.010328104,-0.055665974,0.02895067,-0.055905093,0.011677266,0.06019082,0.12262168,0.08218977 +1.3.1.53,Requires FeII. Involved in the terephthalate degradation pathway in bacteria [2].,384,0.99999994,-0.008046336,0.007739334,-0.030276598,-0.015809953,0.05170571,-0.012108527,0.007478826,0.022859158,-0.0054530953,-0.016485205,-0.023632577,-0.0016008691,-0.04402653,0.090999134,-0.0094637005,-0.035281826,-0.07781974,0.016406061,-0.06974572,0.011809258,0.05683364,0.121214636,0.005228095,-0.051228546,-0.07627988,-0.02955435,-0.010683885,-0.027667968,-0.017104924,-0.019023422,0.043064635,0.110896714,-0.022519985,-0.12054393,0.004089702,0.10245418,-0.04805069,-0.015886473,0.1589159,-0.03922886,-0.014235403,-0.03944258,-0.044280525,-0.0835375,-0.01255324,0.0074711903,-0.0005857636,0.01448339,0.06124983,-0.010149773,-0.11640533,0.060795356,-0.041852586,0.09494285,-0.007532848,-0.05842868,0.06820101,-0.04020712,-0.11542926,-0.011332405,0.005891429,-0.0007424631,0.02266886,0.024264477,0.03723983,-0.025072493,0.0026327926,-0.016095484,0.0662203,-0.00013288572,-0.030948918,-0.018766098,0.030189835,0.083970584,0.023045665,0.09690156,0.03265768,-0.05473644,0.052047238,-0.025466513,-0.01870975,0.0068453006,0.08486202,0.06553286,-0.022300309,-0.0819202,-0.006330782,-0.059031814,-0.010507991,0.08630537,0.057802994,0.024437498,-0.0023653985,-0.019168023,0.0042505567,0.000644399,-0.010544294,0.010421803,0.012922309,-0.035663296,-0.116062574,-0.03864439,-0.093026415,-0.013459112,-0.09600974,-0.032704018,0.044010222,0.020248637,0.041868076,0.007010029,-0.015001336,0.011322704,0.047415722,-0.053976357,-0.036476247,0.053056534,-0.031474333,-0.037665,-0.028420957,0.012357518,-0.013855271,-0.01873522,0.0020163853,0.050554015,-0.03555057,-0.046677824,-0.058926284,-2.182307e-33,0.08368813,0.038991384,0.00947505,-0.015332827,0.013166405,-0.08592172,-0.0587072,-0.07629196,0.024909014,-0.02207328,-0.01382745,-0.06604509,-0.0804442,-0.05334196,0.0127479695,-0.023817996,-0.062957644,0.056196626,0.01960965,-0.06243955,0.080548465,0.03488558,0.042341806,-0.08310144,0.056848302,0.060587723,0.056906022,0.033612605,-0.073536225,0.003906001,0.078519136,-0.0676991,-0.14442307,-0.048573725,0.1077254,-0.020367311,-0.034707535,0.024276653,-0.041932978,0.0043158866,0.0046378877,0.09461479,0.04260614,-0.028210456,0.051918313,-0.057428442,-0.0807203,0.121551335,0.029664299,0.073026106,0.004165705,-0.063744746,0.04731914,-0.013778104,-0.024424883,-0.045430448,0.03420395,-0.101276204,0.012070781,0.023658004,0.02060757,0.020491658,-0.09524797,0.046447508,-0.0037483345,0.012861136,-0.033287164,0.0014185656,0.045827806,0.0647566,-0.03178716,0.02718971,0.018022412,-0.035701033,0.01286808,-0.03943582,-0.048733648,-0.00032752578,0.067107715,-0.0054134247,0.019266866,-0.04042458,-0.07634456,0.03975383,-0.04715364,-0.0109102335,-0.0020309081,0.0037177475,0.047449727,0.020118967,0.09259825,-0.0638048,-0.058678128,-0.00036292354,-0.03137938,-3.5707728e-34,0.05400235,-0.009551718,0.029629832,-0.02136067,-0.07498562,0.033518538,-0.022264168,0.057552233,0.03690806,0.015783854,0.017562345,0.03702927,0.03588342,-0.038050886,-0.031471837,0.008409799,0.05832849,-0.029838374,-0.04524699,-0.026497519,0.0055982457,0.023305325,-0.048993543,-0.011966258,-0.026054924,0.016210709,-0.03868627,0.09537422,0.00086518633,-0.01227792,0.04039286,0.004760566,-0.078093834,-0.052711457,0.015756464,-0.040552538,-0.017822418,-0.017039798,0.019012671,-0.07701655,0.13165408,-0.00013674595,0.027645838,0.071264386,0.0019459317,0.010714204,-0.09488857,-0.035737485,0.08719203,-0.0010402618,0.06765317,-0.045405976,-0.05568671,-0.073161446,-0.02127824,-0.010989514,0.037335288,-0.032144275,-0.023127088,0.0070809294,0.03609383,-0.02538681,0.035488684,-0.017068306,-0.0417904,0.075490385,-0.0038226459,0.079635724,0.09357108,0.024701834,0.09849792,0.03253912,0.07166505,-0.06771479,-0.06820213,0.012251671,-0.05266183,0.023518767,0.049151335,0.064934716,0.0365835,0.022515815,-0.07311691,-0.11491217,0.09711906,-0.006757855,-0.03466386,0.0468191,0.0030180283,-0.0006502221,-0.022391489,-0.044319533,0.04667977,0.0040799314,0.0142483,-2.2673289e-08,-0.024762798,-0.026291173,-0.0017381388,0.07133196,-0.042597875,0.0035953699,0.034299683,0.005038493,0.057055037,-0.018076278,0.041069508,0.103517294,-1.148072e-05,0.011877798,0.07251216,-0.037030216,-0.06536812,0.00936485,-0.01607957,-0.089065924,-0.090447694,-0.015465663,-0.091704816,0.058508184,0.032792144,0.0058886292,0.03752267,-0.07975137,0.04799027,-0.080320865,0.032471273,0.06332059,-0.0032721737,0.021450866,-0.062473383,0.0057967207,-0.02987995,-0.009548451,-0.030836169,0.06345354,0.0017331722,0.08856639,-0.11011088,-0.018607177,0.043582413,0.0027398388,0.012125567,0.0820424,-0.119278245,-0.07441558,0.04673977,-0.01581916,-0.014688541,0.048059218,-0.10108384,0.0576924,0.0013615867,-0.013247785,0.008399893,-0.009436017,0.09669402,-0.030043492,0.093420506,-0.053751525 +1.3.1.54,"The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of precorrin-6A. See EC 1.3.1.106, cobalt-precorrin-6A reductase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.",384,0.99999994,-0.07124944,0.06178951,-0.10613948,0.042127077,0.043746494,0.09310111,-0.10440557,0.004293137,0.0651948,-0.0059561473,-0.0041101403,-0.023160992,-0.05537035,-0.025366124,-0.015827682,0.026357407,-0.082954735,0.017393196,-0.08892665,-0.05071277,-0.033568677,-0.001723929,-0.008603631,0.04662079,0.060440045,-0.06529377,0.027697781,0.0021650258,-0.042166363,0.03976559,0.013173077,-0.015608847,0.0774572,0.010022656,0.0060942546,0.10143101,0.003369581,-0.030437889,0.07242117,-0.009475923,-0.013344712,0.031312276,-0.0015392987,-0.0014143318,0.028333966,-0.008763141,-0.014808646,0.08452502,0.026561975,0.0098061375,-0.01849167,-0.011394969,-0.08146548,-0.04615154,0.048830695,0.069639765,-0.10244281,-0.055513017,0.085415214,0.0042534354,0.053860568,-0.069341,-0.03526701,0.06569955,0.017296894,-0.043729603,0.08397914,-0.030609049,0.03615226,-0.066328295,-0.023054015,-0.062287796,-0.006745064,-0.057174522,-0.02835778,0.07425358,0.002305973,-0.043162066,0.0076734545,-0.0314084,-0.0090870885,0.031791367,0.03822531,0.047291968,0.04535081,-0.031444915,0.024732422,-0.029532135,0.030502262,0.07522959,-0.019223819,-0.010654499,0.025172485,-0.01104429,-0.16680822,-0.016996825,0.050051328,0.057482023,0.005377413,-0.009964227,0.06707073,0.104069136,-0.042336125,-0.023308368,0.033191178,-0.05569612,0.0417853,0.15803052,0.031366922,0.06795553,0.03611658,0.097151905,-0.017674977,0.031164054,-0.0014786819,0.16663627,0.010204768,-0.045928217,-0.08818713,0.057193816,0.018748004,-0.032323584,0.0074157626,0.00851888,-0.059345443,-0.084341384,0.00094724476,1.7463671e-33,0.040168718,0.0092077125,0.022987438,-0.03850145,0.008306647,0.019567268,-0.13252197,0.037876215,-0.03606123,-0.016505418,-0.014734353,-0.055099797,0.04626602,0.017763339,-0.06873102,-0.06006149,-0.007665975,-0.047457904,0.052271027,0.039920945,-0.04846701,0.08098339,-0.0040656775,0.018305534,0.020071283,0.009891569,-0.026325889,0.05324445,0.039806608,-0.0037445955,-0.021723961,-0.025456363,-0.07755448,-0.039345372,0.0020137457,-0.028431049,-0.06948292,-0.008496711,-0.0027345438,0.058686797,0.02250361,0.048931297,-0.10669743,-0.032230206,0.062291745,-0.095460296,-0.0073728613,0.09999083,0.02052333,0.057350766,-0.014277237,0.036066912,0.08858113,0.038387895,-0.04490038,0.03817819,-0.013316693,-0.027615162,-0.0060325926,0.080089964,0.07165567,0.025046153,-0.03321582,0.09562893,-0.041985363,-0.04427919,-0.026537605,-0.05429702,0.027263125,0.03660992,-0.059383485,-0.03602696,0.019112013,0.050621726,0.0011553259,-0.022536822,-0.027003821,-0.033940047,-0.0052414797,-0.07441608,-0.049409296,0.057129752,0.03359188,-0.05865271,-0.06416872,0.049271397,-0.045671754,-0.050880883,0.026463095,-0.042129107,0.023771588,-0.06694513,-0.10310088,-0.010590134,0.061131,-3.4588657e-33,0.14695112,-0.07664931,0.06664477,-0.12862186,-0.008247449,0.04124489,0.07560838,-0.12339765,-0.019018007,-0.05010466,0.09056434,-0.03513717,0.0041447943,0.010689651,0.031558335,-0.0020059778,-0.0037859788,0.07029435,-0.012338026,0.03279175,-0.04102224,-0.00061531493,-0.006009974,-0.014892658,-0.0079187,0.057726353,-0.009726646,-0.006993204,0.048840813,0.06120673,-0.053674877,0.013836026,-0.00021974603,-0.0154075455,0.007401339,0.0948776,-0.015253182,0.010981564,-0.0085000945,-0.027193196,0.028528374,0.020535903,-0.044307776,0.056422714,0.028978491,0.07871398,-0.05768749,0.056149706,-0.07846897,-0.023016913,0.05218652,0.00902536,-0.05535337,0.0446248,0.076122954,9.267157e-05,0.046025798,-0.077194914,0.033979733,-0.087274514,-0.033328768,-0.029819053,-0.0014637191,-0.08028142,0.06316426,-0.019988626,0.0240222,0.094394766,0.052254368,0.012468034,0.063295275,0.083877064,0.001361801,-0.0077781514,-0.08955633,-0.01060104,0.028057203,-0.04767643,0.004897438,-0.037211988,-0.04396619,0.038956445,0.029580623,-0.04487323,-0.07123859,-0.04026791,0.07036902,0.018235639,-0.07520958,0.07241355,-0.04862158,-0.029213231,-0.005794104,0.0026436883,0.031273823,-3.3987973e-08,0.053521894,-0.10516877,0.025991185,-0.016600654,0.019415494,0.043178465,-0.029234232,-0.0018840454,0.011592463,-0.0023153133,0.0108850775,0.07705387,0.039361108,-0.06338153,-0.092183955,-0.03322851,-0.083255686,-0.00022646028,-0.017595561,0.012102101,-0.07242891,0.043012995,-0.08130839,-0.013486563,0.064764746,-0.110141635,-0.031743605,0.052441623,-0.03386115,0.016978564,0.0008806141,-0.044381283,0.058120195,-0.049626082,0.027690321,0.015044902,0.0038638702,-0.02709575,-0.012365283,-0.024467155,-0.04115119,-0.083955705,-0.063482754,0.01334519,0.01413031,-0.016556991,-0.014095725,0.06475878,-0.058608368,0.006350688,-0.006469456,-0.034415975,0.024320051,-0.018863296,-0.046295725,0.054970436,-0.039455716,-0.072667085,-0.03625748,-0.014597243,0.008700968,-0.0057077166,0.08307421,-0.090188175 +1.3.1.56,Catalyses the second step in the biphenyl degradation pathway in bacteria.,384,0.99999994,0.04179495,-0.013352673,0.028980043,-0.018549347,0.05722494,0.04892178,-0.01291571,0.015092527,0.06406098,0.0027979957,-0.009538715,0.017674008,0.02408455,0.06695607,-0.04337856,0.07514856,-0.16832183,0.06485932,-0.028444696,-0.00038610116,0.071461156,-0.011138337,-0.041845065,0.0086988835,0.04402429,0.0019173804,0.08279268,-0.028462805,-0.027010834,-0.06647055,0.06303398,0.015070387,0.061001968,-0.068110615,0.06242121,0.0461385,0.043123893,-0.024887098,0.121975236,-0.02435758,-0.02137794,-0.01432602,-0.027028104,-0.08757461,-0.0070442446,0.049907293,0.005701401,0.007401727,0.009068138,-0.030624574,-0.07261902,0.023900429,-0.012759037,0.021200433,0.07389988,0.029783366,-0.026209615,-0.022234159,0.0037426902,-0.04240716,0.04682994,-0.031182854,-0.002306383,-0.023869356,-0.07291117,-0.07490492,0.043735653,-0.0351974,0.06447545,0.025290817,-0.048170555,-0.050580997,-0.036895644,-0.05233527,0.04383395,0.04020112,0.037274543,-0.11510991,-0.020312093,-0.07506562,-0.03131623,-0.026299542,0.06184033,0.026444016,0.019493142,-0.026227074,0.025216203,-0.06291236,0.027735803,0.03182505,-0.007485057,0.006039793,0.07738593,-0.07239562,0.010574076,0.025827654,0.040216267,0.009940646,0.06985178,0.010624632,-0.053430293,0.05064033,0.0015900173,-0.09641833,-0.04503341,-0.011577296,0.08096454,0.16915643,0.071750104,-0.028662287,0.07014109,-0.0031537735,0.09711601,0.03783735,-0.036712993,0.10836301,0.051667474,-0.018156666,-0.08358129,0.025405478,-0.047130536,-0.022773052,-0.010272767,0.067231186,-0.112269364,0.07625226,-0.00629161,-2.643983e-34,0.06319711,0.017037705,-0.03604958,-0.014136967,0.007961479,-0.04272893,-0.085222036,-0.03309101,-0.009275322,-0.12743135,0.012179445,-0.07968678,0.0016366462,-0.018901825,-0.02515881,-0.026929336,-0.04709842,0.0510845,0.07020206,-0.030354664,-0.017671429,-0.020348903,-0.030861799,-0.024135074,0.0728546,-0.00211236,0.039171487,0.041372452,-0.05213498,-0.032786984,0.04292351,-0.028675409,-0.13194707,-0.00929147,0.061902005,-0.046743702,-0.02497919,0.0016011088,-0.038893875,0.040106777,-0.040172536,0.016658591,-0.006781092,-0.038383376,0.06236442,-0.020908216,0.0042268606,0.12161577,-0.016748192,0.086517535,0.017310468,-0.009279823,0.05810758,0.003331808,-0.051894434,-0.002262373,0.03243972,-0.09233558,0.037199568,0.017620688,0.053556703,0.11890198,0.004421283,0.025672728,0.09518395,-0.0068879053,0.0072866483,-0.042389434,0.036269017,-0.0013194665,-0.08251173,0.024670115,0.041848592,0.0076826815,0.03280802,-0.02802019,-0.09235052,-0.037068397,0.10065573,-0.01127994,-0.03380609,-0.0068923105,-0.02599023,-0.031716023,0.0032586383,0.007933965,-0.04427725,-0.13447338,-0.06165258,0.046785817,0.023837429,-0.07585127,-0.069251955,0.05888824,-0.035597872,-9.793237e-35,0.07790462,-0.0935519,-0.0038430365,-0.005798474,-0.11387031,0.016007308,-0.02173563,-0.028187707,-0.001520111,-0.056302484,0.03851449,-0.0017625659,0.03066898,-0.013240858,0.026231525,-0.042999417,0.14819747,0.017727925,-0.048404794,-0.017342038,0.014867671,0.06325573,-0.062548496,0.053395577,-0.027901955,0.05618473,0.009901617,0.005679951,0.061284635,0.041452,0.029191457,0.022112194,-0.040404297,-0.026240604,0.014887315,0.07851757,-0.064798996,-0.024151854,0.048866004,-0.06896475,0.03392389,-0.0055226334,-0.058325652,-0.028758187,0.028796539,0.019390568,-0.010868871,0.072451346,-0.015023736,-0.078091934,0.038677905,-0.014576074,-0.012238022,-0.05025686,-0.04032142,0.020138599,0.047666382,0.016307492,-0.01178295,-0.028189221,-0.05199691,-0.0005865637,0.11732725,0.043412995,-0.020511014,0.055470575,-0.03781206,0.09140363,0.047944933,-0.096976355,0.033400137,0.024399426,0.074691474,0.053425476,-0.011861949,-0.052307148,-0.018689943,-0.032161698,0.031559646,-0.018870184,-0.025389634,-0.043312296,-0.049564045,-0.066617645,-0.02534894,-0.06646115,-0.04636725,0.037712466,-0.025237579,-0.008691519,0.007493581,-0.056614783,-0.011052268,0.012096151,0.0437713,-1.9403258e-08,0.010196427,-0.010619638,0.041785225,0.011560909,0.021353194,0.027108585,0.021692606,0.055778127,0.030712679,-0.007916204,-0.02379621,0.05775975,0.009126409,-0.02491367,0.013445761,0.056700595,-0.028202482,-0.07393122,-0.023257863,-0.05811195,-0.10658568,-0.037981983,-0.09750911,0.057997793,0.030947417,-0.073126815,0.073003285,0.04088298,0.02059988,-0.07113087,0.07498077,0.00520791,-0.022469835,0.05018176,0.05656446,-0.039390393,-0.023253351,-0.003868601,0.031424068,0.061173048,-0.006948602,0.070087686,-0.1155431,-0.019037882,-0.017360268,0.063091315,-0.0353727,0.07728272,-0.077530414,-0.004638446,0.10304852,-0.03322586,0.036345,0.04964508,-0.09903631,0.008628305,0.06210623,-0.052543998,0.027935687,0.0057268534,0.03824597,0.026968844,0.114289284,-0.04364001 +1.3.1.57,Involved in the gallate anaerobic degradation pathway in bacteria.,384,1.0000001,-0.029619299,-0.08151851,-0.010211308,0.048362374,0.040005837,0.0015851007,-0.0061170473,-0.027094323,-0.010415699,-0.024603296,-0.028425101,-0.04426755,-0.009180885,0.054477848,-0.081770346,0.033495933,-0.084767684,-0.02032202,0.032707125,0.025937004,0.0061902474,0.03226405,-0.01306947,0.058108117,0.012478031,-0.023339769,0.04489642,-0.01841433,-0.12262738,-0.035538696,0.047705393,-0.00060309505,0.12958667,-0.022568693,0.00589585,0.12445392,0.008544921,-0.05850927,0.09712847,-0.036598764,0.0073958402,0.064209215,-0.0066420976,-0.03315244,0.0882255,0.10032031,0.021245722,-0.042176746,0.049113445,-0.070373185,-0.036267236,-0.03352737,-0.05450027,0.013518715,0.09146426,0.005102335,-0.00055776443,-0.1368657,-0.036046166,0.020829266,0.015572289,0.014495911,-0.010116613,-0.019773064,-0.07049574,-0.04556753,0.09134043,-0.01872339,0.004047652,0.0011540294,-0.11182819,-0.03173188,-0.05282703,-0.003128935,-0.00089433545,0.053465273,0.0024790305,-0.060224053,-0.026594965,-0.12591277,-0.025529532,-0.07760393,0.030001167,0.021892458,0.03364313,-0.07837387,0.07228033,-0.034846574,0.080673724,0.018006641,0.002863062,0.0906123,0.03772382,-0.07157994,0.01435606,-0.057366014,0.034226313,-0.0091130445,0.012510579,-0.03556866,-0.022097044,0.084817,0.00011327515,-0.09184771,0.027269026,-0.0013683455,0.0673284,0.108194634,0.041579966,0.028983505,0.018776702,-0.0077475864,0.0736695,-0.03508709,0.018807696,0.07609712,-0.00487628,0.009257867,-0.090335004,0.097925544,-0.09028366,-0.047336604,0.0068176733,-0.011405132,-0.05428812,-0.01878601,-0.04044627,-1.2292152e-33,0.062190738,-0.032950282,-0.011647077,-0.01493746,0.01631537,-0.051235106,-0.09759704,-0.094894566,0.09393754,-0.04238683,0.07268027,-0.040612146,0.00763855,-0.005165112,0.040917136,0.07591441,-0.011782331,0.02972461,0.018909557,0.0028590155,-0.09852703,-0.007029836,-0.025943121,-0.07700565,0.112652145,0.029849585,0.039809853,-0.032204498,-0.09954184,-0.029959336,0.06594569,-0.034360275,-0.08800138,-0.004190852,0.07747714,0.055424366,-0.050203606,0.028563041,-0.046018984,0.0703465,0.054736245,0.02473474,0.028499873,0.042787336,-0.017454261,0.00804648,-0.05140493,0.08450854,0.048477925,0.062243663,0.02128466,-0.035188884,0.05972717,-0.053049672,-0.0081262505,0.014793297,0.05483237,0.049266778,0.068850435,-0.033165872,0.052739024,0.04478188,-0.08843997,0.047625925,0.0380297,-0.026565831,-0.08455749,0.029389367,-0.03381494,0.04751987,-0.07479821,-0.09115967,0.0045325393,0.0014963786,-0.057971116,-0.0058945846,-0.10424864,-0.025065249,0.015141275,-0.04553923,-0.03897327,-0.008952006,-0.023319071,-0.06309325,-0.01762145,0.080103956,0.03289451,0.06018514,0.027217884,-0.016122997,0.053110026,0.016840816,-0.023649832,0.018571842,-0.0072525656,-8.0432254e-36,0.069208145,-0.0112420665,-0.040028162,-0.014323896,-0.039440054,0.0098968,-0.019927807,0.061294824,0.0008616115,-0.017616782,0.01859067,0.018530352,0.0011304651,-0.025216624,0.074697636,-0.036479384,0.07595703,0.021420982,-0.06566903,-0.0008502485,-0.003454874,0.07578988,0.00082327,-0.044417635,-0.018805355,0.06887336,-0.012987989,0.07631826,0.035268355,-0.0029303657,0.01818145,0.0057247705,-0.023993952,-0.079355486,-0.051226247,0.045238134,0.019833583,-0.043906298,-0.020902691,0.0333433,0.07385498,0.019848213,0.015700836,-0.005933548,0.00806648,0.049230892,0.009214259,-0.008855806,0.0057496214,-0.008552177,0.05206237,-0.07400341,-0.030564345,-0.012272989,0.017238721,0.03026272,-0.017008683,0.014367807,-0.034250423,-0.10598214,-0.08157373,0.028342772,0.14073777,-0.02453236,-0.028171048,0.050194,0.005016746,0.061479256,0.025247013,-0.04524039,-0.029337568,0.0885521,0.023758927,0.022561016,-0.060023177,0.030948812,-0.06426557,0.006604098,0.053039692,0.012185382,0.02929127,0.019902453,-0.039180517,-0.021174911,-0.025515718,-0.08501786,-0.052870672,0.012702585,-0.0058800136,-0.058260746,0.07676235,-0.1389589,0.012233868,0.012182669,-0.052522253,-1.5043412e-08,-0.026236124,0.031847697,0.034693863,0.057797182,0.035048112,-0.052990824,0.028626468,0.043974474,0.10495508,-0.028720032,-0.016300727,0.05621869,0.04161396,-0.041195773,0.0076469867,0.03932622,-0.023085224,-0.026377685,-0.03656382,0.010627234,-0.069845684,-0.07922399,-0.046013307,0.11080481,0.06278695,-0.022871224,0.06221415,-0.0051929564,-0.056076698,-0.058362048,0.018757207,0.022668524,0.012315979,0.0017833383,-0.013530669,-0.08164039,0.011138706,-0.062507235,0.043650556,0.063877955,-0.024203641,0.0018255616,-0.14749354,-0.0004310568,0.045294162,0.073089436,-0.018259553,0.022628903,-0.08222744,-0.029957158,0.03487401,-0.04471232,0.06247702,0.04015364,-0.03935673,0.021378584,0.11710055,0.0067533297,0.0142824035,0.016177561,0.0180501,-0.040614303,0.12256233,-0.050632115 +1.3.1.58,Involved in the p-cymene degradation pathway in Pseudomonas putida. 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+1.3.1.59,Involved in the m-xylene degradation pathway in bacteria.,384,1.0,0.016541863,-0.028725011,-0.009015866,0.002562545,0.095279366,-0.0099631585,0.004264892,0.05393328,0.010927391,-0.009677726,0.046714503,0.03371636,0.07917051,0.09678859,-0.012918066,0.046948306,-0.111574404,0.048216175,-0.036430165,0.07178638,0.109198034,0.05284884,-0.015152238,-0.021123061,0.00677157,0.00887227,0.043042384,-0.06127636,-0.013959582,-0.062495008,-0.008310542,0.055876486,0.047501296,-0.04306082,0.088100426,0.06648275,0.035189733,-0.0906701,0.04677352,-0.04870104,-0.014357778,-0.023641502,0.011047532,-0.08678851,-0.013938124,0.022188121,-0.020739898,-0.0119226035,-0.030933201,0.0019532267,-0.0067905863,0.018713037,-0.04031822,-0.0247568,0.04861719,-0.0126792565,-0.013394952,-0.03624506,-0.025894526,-0.013767647,0.09830139,0.02756715,0.06774438,0.03425367,-0.036290143,-0.046373963,0.010455009,-0.025547687,-0.016554741,0.008574309,-0.138051,-0.040015806,0.015108979,0.018036306,0.029348332,0.053946868,0.027644116,-0.082328916,0.0066536306,-0.00767793,0.021150297,0.02475595,0.0142842205,-0.008022388,0.030976707,-0.024922162,0.009241088,0.008171655,-0.03594815,0.091485076,0.040761698,0.06125826,0.03808442,-0.038111728,0.0030185026,0.014400754,0.124183595,-0.013588132,0.034537584,-0.030127242,-0.054522257,0.013168685,-0.050255846,0.021778941,-0.0118662985,-0.08176677,-0.005703948,0.07593877,-0.03817498,-0.024474103,0.03734125,-0.05789212,0.041278422,0.02249183,0.01279184,0.0734623,0.10141958,0.008962205,-0.0307044,-0.03811882,-0.07244038,-0.10808056,-0.05947317,0.0016542097,-0.018256508,0.011680429,0.0010189054,-2.4454309e-33,-0.0036226085,0.03828525,-0.023897594,-0.05874483,0.06354753,-0.048924703,0.04595735,0.046465036,0.083731934,-0.03334225,-0.027548844,-0.047880933,-0.009583303,-0.061289072,-0.08353507,0.00878317,-0.05235973,0.008376656,-0.012768097,0.0005314308,-0.017018406,-0.010917997,0.017963178,-0.050567597,0.026256941,-0.007697003,0.01739569,-0.053742014,-0.02653076,-0.060011216,-0.059866793,-0.054171402,-0.069592945,0.02533615,0.030229317,0.034066495,-0.06436228,-0.07136514,0.0007822326,-0.0029495864,-0.045312904,0.021188373,0.041820195,-0.055927824,-0.06843783,0.054707326,-0.056501895,0.055145584,-0.0115953125,-0.037565716,0.04542843,-0.002427969,-0.015757343,-0.048137587,-0.005567939,0.007078597,-0.02485931,0.02117389,-0.03879431,-0.012488173,0.018303197,-0.0035409015,-0.05344954,0.055817936,0.063784726,0.02840029,-0.08242105,0.010303145,0.046975117,0.027643858,-0.06509366,-0.0820899,0.0510639,-0.043867223,0.024960274,0.042564,-0.108130306,0.05871512,0.06677516,-0.012084262,0.079213426,0.045818355,-0.0017327552,-0.078437045,-0.04760732,-0.012004925,0.02583799,-0.043973334,0.09064211,0.08523407,0.071132034,-0.11590044,-0.060067885,0.053468525,-0.04357221,1.4194852e-33,0.058914278,0.032120176,0.05498117,0.05681125,-0.06351709,-0.025662525,-0.018142253,0.03047818,-0.024298936,-0.070183866,0.08438154,0.08303343,0.046171352,0.014240375,0.013955437,0.01474788,0.12278437,0.004360906,-0.04757568,-0.06229259,-0.06254271,0.06774742,-0.016151957,-0.045046844,-0.02658566,0.03214801,0.004288676,0.0006691812,0.10479898,-0.001051994,0.041200362,0.01801209,-0.02731901,-0.0009795019,0.010372581,-0.04604699,-0.008585956,0.019690465,0.05098223,-0.009497226,0.055054255,-0.026877748,0.03163606,0.048669744,0.012498285,0.12220587,-0.011853035,-0.030992363,0.09000974,-0.0031173814,-0.01802517,-0.015037391,-0.09636836,-0.012265003,-0.056270607,0.062157374,0.029715212,0.04114072,-0.03232931,0.020983009,-0.08538528,-0.032547243,0.07659701,-0.033684198,-0.023073042,0.024766445,0.019508902,0.09640533,0.0014926846,-0.06867647,0.12105912,0.054180797,-0.004360018,-0.0061678146,-0.10366753,-0.02881711,-0.07401367,-0.06955558,0.047921464,-0.031199481,0.032907676,0.009409023,-0.09174076,-0.057546604,0.029700803,0.005612419,0.0020839134,0.08799388,-0.015275274,-0.06821922,0.04995071,-0.069495074,-0.041387223,0.015080198,0.123321995,-1.702896e-08,-0.054174453,-0.025835978,0.03244821,-0.0091874115,0.02375717,0.005802356,0.04905503,0.096143425,0.15256341,-0.026182847,-0.013110234,-0.048876982,-0.033658102,-0.0037724338,0.0069816546,-0.01531744,-0.07438331,-0.060088985,-0.0015311607,-0.069394924,-0.09610374,-0.10045342,-0.0634521,0.06330359,0.046390012,-0.0509195,0.108366475,0.055717297,0.061008465,-0.10308629,-0.020867875,0.016571982,0.021936852,0.06974675,-0.029517092,-0.010247477,0.014343196,-0.057298586,0.07894744,0.032694466,-0.012247294,-0.007896145,-0.08190404,0.029242517,0.026422104,0.07909904,-0.015884917,0.03622625,-0.09982405,-0.06037979,0.05490786,-0.029917557,0.02347911,-0.037219997,-0.035364885,0.00761576,0.037668213,0.068936914,0.037749123,0.006986384,-0.023202637,-0.03716509,0.14993511,-0.066688515 +1.3.1.60,Involved in the dibenzothiophene degradation pathway in bacteria.,384,1.0,-0.083051056,0.039754324,0.046290692,-0.010634621,0.053497627,-0.047268182,0.035091188,0.06743059,0.015618154,0.044703558,-0.04059907,0.0044065076,0.0170941,0.09465677,-0.10405941,0.090309024,-0.09476469,0.04673652,-0.055016633,0.05041784,0.023524819,0.044378247,0.014209478,-0.025417084,0.02832609,0.026439201,0.06311993,-0.004523181,-0.02457996,-0.028870098,0.05014458,0.030429881,-0.0054410174,-0.043018043,0.07045958,0.10954605,0.03845181,-0.06260478,0.036516327,-0.022454925,0.02045159,0.08206817,-0.04159506,-0.034811787,0.037555143,0.04430424,-0.017643455,0.06312572,0.06834654,-0.08387989,-0.059801396,-0.015020431,0.024654042,0.09593358,-0.022059876,0.024167337,0.04813753,0.01856432,-0.11358362,-0.056822386,0.0080436915,-0.013911488,-0.016836109,0.0058969324,-0.066145375,0.05072672,0.014198652,-0.012946716,-0.004236722,0.05331981,-0.12669848,-0.052449077,0.0010234844,-0.024918068,0.05602936,0.025806315,0.04931045,-0.027105326,-0.050900426,-0.10303012,0.028784174,-0.023628939,0.112822115,0.019055797,0.022581248,0.059931338,0.007523002,-0.061247338,0.03836575,0.025802867,-0.035732098,0.010870995,0.06226065,-0.04069556,-0.060155246,0.047924947,0.023301283,0.060758352,0.045450337,0.029961223,-0.035201296,-0.06610417,-0.1041701,-0.08436916,-0.054912206,-0.0025238201,0.05082431,0.06959453,-0.0059162974,0.00066837936,-0.025948975,0.026546007,0.068004735,0.028866,-0.016304715,-0.022757953,0.053848147,0.03139569,-0.015725562,0.0189178,-0.055088785,-0.056132928,0.020286659,-0.010644843,-0.07754533,0.04871366,-0.0008990614,-4.7202394e-34,0.0023295477,-0.03403517,0.03280129,-0.056019355,0.0545844,0.010707599,-0.07515745,-0.03909828,-0.005796841,-0.085798234,-0.072714515,-0.09694385,-0.026102167,-0.08979061,0.0129072005,0.02556493,-0.04645689,0.09185733,0.018147323,-0.002319629,0.015749142,-0.009157164,-0.04987426,-0.043404292,0.059187744,0.06939435,0.03135574,0.060648654,-0.070720315,-0.038472317,-0.03344068,-0.03904522,-0.11789691,-0.038989823,0.03780936,0.043966703,-0.053762943,0.014906569,-0.040136922,-0.032158326,-0.012228803,0.012627643,-0.06638078,-0.01697693,0.02845579,-0.015954703,0.0032652286,0.047315285,0.012387726,-0.013774773,-0.0070413565,-0.06333633,0.074378386,0.020763045,-0.10267469,0.015797025,0.07056392,-0.043074895,0.0795415,-0.020147001,0.006043229,0.048949793,-0.08703099,0.010835555,0.073031224,0.0007536805,-0.036776427,0.018674647,-0.02119156,0.040839825,-0.07554175,-0.039574236,-0.023756264,0.037069373,0.019198667,-0.07330615,-0.07638755,-0.008030533,0.07363041,0.017020928,0.03604782,-0.09254036,-0.009717856,-0.064429514,-0.027229207,0.09278619,0.04508663,-0.020733662,0.018419025,0.034109686,0.10135057,-0.104832955,-0.027186876,-0.03291422,-0.007199247,-4.7865988e-34,0.06547517,0.05681627,-0.011764485,0.019046541,-0.031619232,-0.032088928,-0.1027305,0.060133774,0.044590615,-0.024413502,0.047037292,-0.035256375,-0.003348797,0.022296932,-0.008953965,-0.0036546576,0.05291698,0.013410156,0.022585625,-0.06852234,0.003218245,-0.010316675,-0.042260487,-0.020597612,-0.08053419,-0.024682244,0.024233686,0.12082122,0.058218762,-0.0038802477,-0.06521445,0.09886068,-0.031284116,-0.0030851162,0.0024499937,0.003747148,-0.11648698,-0.0036872022,0.0550834,-0.02102746,0.0056113824,-0.024648035,0.0060298215,0.0431912,0.041080963,0.10492867,-0.1174949,0.01584838,0.0020024884,-0.01254469,0.017143667,0.028560031,-0.01881854,0.0032454599,-0.017689751,0.035731163,0.0025833587,0.005980256,-0.028679961,0.026366204,0.0034588228,0.00970114,0.02625274,0.12354189,0.041188683,0.0683058,-0.058939938,0.14755689,0.006263015,-0.01811931,0.011408467,0.054314785,0.045542914,0.008797969,-0.09832557,-0.01786749,-0.09379883,0.04907989,0.055002127,0.05078247,0.028832735,-0.0021068864,-0.041245695,-0.033933263,-0.056793332,-0.09296778,-0.03069434,0.061101247,-0.033121333,0.0147837335,0.029127104,-0.05010636,-0.0053810254,0.048930302,0.004436359,-1.9068121e-08,0.023638736,-0.059128635,0.041232586,-0.011889794,0.004733633,-0.069992244,0.071642905,0.081317544,0.099741004,-0.021744622,-0.036677223,0.022088634,-0.01597683,0.035536006,-0.0019947847,0.09545316,-0.04877279,-0.0625519,0.02236531,0.016752217,-0.019140024,-0.07600634,-0.03603871,0.08079957,0.07706367,-0.030570084,0.07927433,0.050839845,-0.0057200603,-0.07807959,-0.023186143,0.01750817,0.023047404,0.022529874,-0.030411305,-0.009135526,-0.12494621,-0.036338568,-0.009749921,0.039592564,0.006845334,0.059324358,-0.039452024,-0.013490323,0.057831176,0.058148492,0.04848294,0.059184067,-0.010700742,-0.08831407,0.047564443,-0.004189562,-0.010780004,-0.062132124,-0.13789941,0.018342521,0.05078664,0.043380648,0.008412227,-0.040807515,-0.02204666,-0.0302271,0.10844267,-0.016081119 +1.3.1.61,Involved in the terephthalate degradation pathway in bacteria.,384,1.0,0.008481804,-0.009655226,-0.009145976,-0.009949179,0.02197081,0.009058165,0.0052960697,0.021014508,0.025716113,0.009576939,-0.034943275,-0.004571588,-0.0023052145,0.04193804,-0.012086454,-0.023741608,-0.06591438,0.011968991,0.003203815,-0.015152183,0.027479555,0.12471468,-0.031278543,-0.061187457,0.032062434,0.025785685,0.045170177,-0.071083926,-0.0026763747,-0.0038017386,-0.006348853,0.006268884,-0.06477788,-0.05602723,0.05874949,0.08372449,-0.04664328,0.010489588,0.124132946,-0.0629624,-0.0069025815,-0.014202487,-0.0704553,-0.057343382,-0.066692255,0.04239593,-0.034080442,0.03926334,0.0045835525,-0.049077325,-0.041428965,0.0032436908,-0.02454363,0.061391417,-0.045994453,-0.059711356,0.08302137,-0.0014542821,-0.10489246,-0.031136837,0.0025818476,-0.007055482,0.0054314006,0.0045332154,0.026869845,-0.035098042,0.038370416,0.060496025,0.004317184,0.009867166,-0.119990826,-0.0072296164,0.06499729,0.087531365,-0.012394383,0.018349187,0.05799791,-0.06704038,-0.034833588,-0.035344057,0.04661547,-0.0015526508,0.06389868,0.051235948,-0.019360181,-0.081222124,-0.02406629,-0.025949724,-0.008470444,0.049931474,0.05218042,0.012309201,0.014635582,-0.054347888,0.016244281,0.032102402,-0.0061535714,0.021931468,0.07180975,-0.06774413,-0.12137255,0.0006297179,-0.08333776,-0.0636687,-0.04459469,0.0036009962,0.03525964,0.081518926,0.09969527,0.00030863393,-0.023658901,0.004635486,0.057023022,-0.012468107,-0.033559047,0.027295195,-0.0046551246,-0.013739977,-0.08227867,-0.00033052848,-0.02390104,-0.054697827,0.022162642,0.027708894,-0.06672406,-0.017133202,-0.014233227,-2.4610993e-33,0.07468373,0.018247621,-0.0014660163,-0.049492422,0.033416376,-0.05180623,-0.02054996,-0.049729694,0.036825728,0.035840187,-0.026690178,-0.12656572,-0.05865942,-0.054547433,0.008968117,-0.0045614,-0.095251285,0.08966153,0.0074976846,-0.05715636,-0.024712682,0.070780426,-0.0040281126,-0.01677748,0.021265185,0.068924755,0.06314703,0.0734377,-0.089989625,-0.02010171,0.0702381,-0.013779895,-0.17027894,-0.045162056,0.13102971,-0.023239458,-0.04542551,0.05700155,-0.013428527,0.014447952,-0.0028380824,0.042816058,0.007288126,-0.058393583,0.030022752,-0.0656719,-0.046301752,0.13397647,-0.036242094,0.029008254,0.022203552,-0.061896175,0.03954423,-0.028120402,-0.043130096,-0.044660237,0.05225149,-0.07942481,0.009588774,-0.004862921,0.06356575,0.013505214,-0.09629734,0.007681982,-0.023719193,0.0049734022,-0.06259564,-0.0020336981,0.036819536,0.050620433,-0.026392918,0.04203899,0.08269366,-0.046597682,0.025619432,-0.016351426,-0.078314446,0.06361295,0.064884074,-0.032489713,0.031105397,0.0003451752,-0.026577702,-0.027796188,0.003951607,0.0077358875,0.008218034,-0.0057650646,0.03447924,0.036979545,0.06908031,-0.059474267,-0.10300347,-0.0259966,-0.037308645,2.375576e-34,0.10059136,0.03294708,-0.017709292,-0.028301684,-0.022647988,0.021264108,-0.014701929,0.12918134,-0.012096702,-0.010072917,0.085856095,0.05587302,0.043656494,-0.010294399,5.661898e-05,-0.013291798,0.09076467,-0.0046350383,-0.067674115,-0.110072754,0.010252432,-0.034730054,-0.085651405,-0.01727455,-0.012782531,-0.011708648,-0.017356085,0.10144213,0.03056392,0.0064596343,0.047863696,0.0058956053,-0.012256699,0.029825643,-0.0070987977,-0.025135586,-0.019699855,-0.02105163,0.010080874,-0.05097409,0.09023365,-0.023545533,0.013235523,0.02797044,0.020968597,0.024843782,-0.093356945,-0.044651765,0.08995546,0.0014227043,0.07576576,-0.031302508,0.0025201137,-0.019441163,-0.004656178,0.03046313,0.006577447,-0.02163852,-0.01595264,-0.031304643,-0.004005488,-0.014142418,0.05610122,0.04841314,-0.0069556143,-0.011073009,-0.021430667,0.10118174,0.07704866,0.010787547,0.03753183,0.044374984,0.037588473,-0.08403743,-0.064926304,-0.04466853,-0.032233454,0.0032006546,0.04342153,0.035561495,0.038517196,0.0036890584,-0.07577978,-0.09836998,0.07423538,0.030310813,-0.012928793,0.10041915,-0.009557143,-0.011518095,-0.05458972,-0.0726408,-0.0107191615,0.0390989,0.0786481,-1.9550528e-08,-0.03288709,-0.030182619,-0.0024312707,0.07131119,0.010928822,0.037318356,0.04820184,0.07633634,0.044293456,0.005409564,-0.0151505405,0.04702012,-0.025305916,-0.002493799,0.056196813,-0.025534129,-0.09164827,-0.035095844,0.00041983806,-0.05947011,-0.06549296,-0.045518786,-0.058184322,0.09793382,0.0752696,0.017536223,0.020661231,-0.07827935,0.01691974,-0.0854919,-0.008015765,0.06556331,-0.042156167,-0.006656586,-0.060084596,0.009614899,-0.05020212,0.0012599662,0.021294117,0.10436649,-0.016751038,0.09969038,-0.14244011,0.016419902,0.0919085,0.060347416,0.01385865,0.054171346,-0.14916499,-0.09365115,0.023064708,0.0039572087,-0.02963343,0.036501173,-0.059969947,0.055497486,0.02159196,0.013270473,-0.021852188,0.021935169,0.05942576,0.004687305,0.124625,-0.038609073 +1.3.1.62,Involved in the benzoate degradation (anaerobic) pathway in bacteria.,384,1.0,-0.05238989,0.025011042,-0.007661872,0.016794998,0.06754983,0.075773016,-0.03127474,0.037279706,0.023962,-0.018190175,-0.04463278,-0.07760194,0.012376995,0.113061525,-0.09411742,0.029866347,-0.11724564,0.025117667,-0.06235049,-0.006385182,0.011538344,0.056444563,-0.015031448,0.035959873,-0.0013749142,-0.06775841,0.012556741,-0.042554263,-0.07963252,-0.03778354,0.045975897,0.010888055,0.08360355,-0.049437247,0.10745342,0.0630712,0.021535996,-0.057941858,0.12859324,0.039907943,-0.019070826,0.011835029,-0.0613861,-0.007232312,0.064888805,0.08460255,0.04916114,-0.026773443,0.036145408,-0.06306842,-0.07641953,0.017915811,-0.030259408,-0.006631361,-0.01904244,0.0024678786,0.03848238,-0.024192682,-0.06566074,0.027512783,0.054742917,-0.019432822,0.020924022,0.009680512,-0.089362636,-0.04907758,0.086035304,-0.021377407,0.032817453,0.027798636,-0.14570647,-0.07485302,-0.033974055,-0.020197738,0.004928495,0.019717459,0.0054920306,-0.08054288,-0.058723133,-0.10571929,0.013688233,-0.05761842,0.018653497,-0.007634967,0.0034021009,-0.075928554,0.004462085,-0.04542476,0.105385885,0.0738083,-0.03888294,0.04104291,0.017077697,-0.07989143,-0.05967431,-0.024810262,0.04176943,0.041338623,0.03685041,-0.008611472,0.009733695,0.075730324,-0.007687494,-0.066708714,0.042377636,-0.00558362,0.101691276,0.11642353,0.024432493,-0.0022343986,0.017709075,0.017180463,0.05347896,-0.015659602,0.0017331742,0.06669587,0.032714147,-0.00895237,-0.10755074,0.09045497,-0.012252117,-0.07270624,0.0052452357,-0.023487486,-0.05942296,-0.0014169738,-0.04123636,-2.0648333e-33,0.036451682,-0.021162594,-0.0019921095,-0.01494228,0.009371595,-0.053144224,-0.110848434,-0.08796076,0.050624523,-0.07935712,-0.016337868,-0.051120225,-0.015776223,-0.012955915,-0.03920476,0.066651456,-0.0586097,0.050011817,-0.052410774,-0.0063909353,-0.0029316205,0.019200027,-0.024859603,-0.092472784,0.103056006,0.024466844,0.019026466,0.02622138,-0.08609036,-0.033400822,0.01052192,-0.040413976,-0.14997387,-0.02286152,0.05433122,0.026412465,-0.03872825,0.020167287,-0.0066841287,0.039396815,0.01382177,0.09450085,0.024969554,-0.0043669464,0.015721224,0.0054836646,-0.03443578,0.13363945,0.061799396,0.0071663926,0.027787436,-0.060696125,0.02148733,-0.017808566,-0.0020507586,0.028605472,0.07138499,0.032095633,0.023265071,-0.02379626,0.058225658,0.06170853,-0.098309554,0.032289587,0.04895385,-0.003940164,-0.043384768,0.08867033,0.007066936,0.021543745,-0.08079765,-0.020001298,0.057172727,0.075777695,-0.028877186,-0.078476116,-0.12666959,-0.06749426,0.0497641,-0.022214778,0.0039971424,-0.051189303,0.011834505,-0.0413402,-0.013587471,0.016003147,0.012925164,0.013882835,0.024045104,-0.011876471,0.037947573,-0.065344475,-0.0205924,-0.030020284,-0.016148478,-3.6570183e-35,0.07556073,0.067763075,0.00420106,-0.017996518,-7.955622e-05,0.02890903,-0.04150491,0.063669086,-0.046743494,-0.026080556,-0.004978044,0.017976273,-0.0022571422,0.00755516,0.02636464,-0.051277258,0.09075306,0.008650922,-0.073880725,-0.051757462,-0.04607811,-0.0068142954,-0.0242043,-0.015430698,0.005339979,0.04583941,-0.008515181,0.06782441,0.0013301527,0.03138804,0.025050536,0.04785936,-0.04063603,-0.079781435,0.025451498,0.03828326,-0.025374468,-0.018847866,-0.026794216,-0.01943477,0.01896951,-0.072965235,0.008845028,0.014672753,0.024254154,0.05586274,-0.06452913,-0.044631004,0.02681257,-0.019802503,0.025867557,-0.030070405,-0.027239341,-0.017898977,0.016340343,0.039483868,0.021790817,-0.008975296,-0.009366487,-0.014716435,-0.026092097,0.023209272,0.069658615,-0.0032738359,-0.021833671,0.02857905,0.020745827,0.13040143,0.016913941,-0.01872256,0.048801,0.086714946,0.08220736,0.033340048,-0.100663245,0.004757407,-0.05965703,0.002584088,0.03386844,-0.0075617023,0.0370589,-0.022347061,-0.035674118,-0.046571665,-0.050534893,-0.08026618,-0.049595386,0.019712353,0.008500117,-0.03284924,0.05030641,-0.09437824,-0.018406112,0.051045414,-0.014610035,-1.8458877e-08,0.038228817,-0.031305358,0.06351605,0.0056966585,-0.020297147,-0.027237955,0.008202828,0.04281189,0.09604764,-0.041769877,-0.026232718,0.024180261,0.019889599,0.012293701,-0.013214099,0.028717991,-0.0666161,-0.00064587337,-0.012215304,0.09148299,-0.08886083,-0.033125043,-0.08201075,0.06307982,0.08457034,-0.046453927,0.057924755,0.06387857,-0.004469068,-0.07453779,0.05065447,0.035222024,0.03154156,0.08689926,-0.06151656,-0.053263936,-0.020308973,-0.049103096,-0.03310542,0.041224107,0.00092297595,0.030859081,-0.13497415,-0.017062386,0.12412755,0.074367434,-0.026809415,0.09138892,-0.047070645,-0.06889013,0.034022126,-0.02329552,0.0059341467,0.060260274,-0.072149806,0.03919862,0.057499208,0.041707896,0.039736237,-0.008975723,-0.007532718,-0.01299617,0.13386181,-0.0437847 +1.3.1.63,"Acts in the reverse direction to form part of the 2,4-dichlorobenzoate degradation pathway in bacteria.",384,1.0,0.0070855333,-0.023667594,0.019917388,-0.026435861,0.078062505,-0.033162538,-0.0013541003,0.008506563,0.008328687,0.034022145,-0.025206372,-0.03548459,0.0014620741,0.07069673,-0.041545834,0.09878017,-0.08238415,0.03608091,-0.03872464,0.042875007,0.039139725,0.009132746,-0.08436681,-0.026604826,-0.013561924,0.08198089,0.083986856,-0.0038804454,-0.016011773,-0.106656455,0.052016623,0.04776863,0.07469846,-0.037902396,0.037819084,0.08908569,0.048556376,-0.07153926,0.09324363,0.029730553,-0.004506215,0.09669716,-0.01901333,0.007898024,-0.027764784,0.054525755,-0.02485754,0.03497637,0.051493984,-0.025451586,-0.04265689,0.061550174,-0.062540844,0.059149697,0.0017718419,0.044740587,0.03204498,0.050808836,-0.06313981,0.0032256695,0.09392672,-0.030880582,0.005197246,-0.020134805,-0.036274515,-0.012278415,0.06326135,-0.0021291568,0.031765558,-0.004819892,-0.08929487,-0.0099521205,-0.004080037,-0.0426495,0.024799066,0.035669792,0.034279253,0.015597954,-0.0179104,-0.06952181,0.03061819,0.004930353,0.11979878,-0.003509081,-0.001844533,-0.06732122,-0.029401014,-0.14149716,0.09460681,0.06264505,-0.01528571,0.028963612,0.054217737,-0.054883093,-0.008314259,0.074305534,-0.03644618,0.002407385,0.09157497,-0.0039396156,-0.031761788,-0.017885862,-0.06970313,-0.05848489,-0.022248728,-0.038371608,0.01404596,0.08804025,-0.009982687,0.03132624,0.048440967,0.05755316,0.14968947,0.028700307,0.040870346,0.0076563447,0.032146666,0.02617212,-0.03672538,0.03943062,-0.03715378,-0.027009154,0.022783197,-0.014107058,-0.08952386,0.028345246,-0.061465792,-1.2191582e-33,0.047479656,0.0040206346,0.026299478,0.023157107,-0.022909837,-0.025419127,-0.07152487,-0.024974791,-0.037552383,-0.09091368,0.05588748,-0.10314102,-0.019236185,-0.03142609,-0.048986733,-0.04266142,-0.020769052,0.06966841,-0.013877027,-0.013893223,-0.051503703,0.08161312,-0.045586757,-0.06644997,0.047658265,0.09142074,0.04193771,-0.012756005,0.03315893,-0.012874472,0.0154995285,-0.015695766,-0.13138661,-0.014956911,0.06262357,0.017187707,-0.02765605,-0.009752606,0.024947148,0.013847906,-0.029146047,-0.015092371,-0.07720493,-0.042452127,0.06922039,-0.036298104,0.008408432,0.083456606,0.047423955,0.011347432,-0.038671568,-0.06848905,0.07644815,-0.023821369,-0.051133014,-0.007399705,-0.012273872,-0.049637493,0.044991035,-0.04668365,0.04972037,0.11077747,-0.14106898,0.035723135,0.034015056,-0.06547478,-2.1245605e-05,-0.025537645,0.00855392,0.033245284,-0.036197368,-0.05909368,0.019123757,0.045760073,0.0153795,-0.07301695,-0.07024181,0.005666453,0.096097074,-0.0053017233,-0.012695856,0.021267716,-0.01609156,-0.056533944,-0.07636159,0.03893647,0.034631412,-0.08193532,0.00041647683,0.04227298,0.06940671,-0.071260005,-0.065529145,0.041248526,0.012174061,4.5168706e-34,0.042681225,-0.015982488,0.0027540158,0.046145547,-0.082021065,-0.020130487,-0.03979853,0.022261767,0.019058932,-0.0016885916,0.027645491,-0.016110606,-0.06503723,-0.020474862,0.0026432602,0.016951729,0.1179735,0.032463875,-0.05832763,-0.07361436,0.051857214,0.05332177,-0.0060399906,0.0031647114,-0.00884469,0.031473257,0.047093783,0.07727958,0.078124024,0.024060454,-0.057403926,0.08931746,0.035820823,0.0041512214,-0.062346414,-0.0145814745,-0.12248374,-0.030506115,-0.0005759378,-0.029626712,-0.041189633,-0.0007279891,0.019006642,-0.014670434,0.01963849,0.048685547,-0.031118074,0.053110912,0.06904477,-0.05484506,-0.007908954,-0.02171594,-0.07032097,0.034956828,-0.028314827,0.0029380466,0.0123157175,-0.00032311789,0.0056582857,0.014868946,-0.03510431,-0.012738092,0.100646555,0.0044587604,0.052730203,0.06827443,0.0036172315,0.09362394,0.039984353,-0.0461841,0.04229402,0.060702886,0.055437513,-0.034202762,-0.04131863,-0.006164579,-0.0960389,-0.01337322,-0.054370858,-0.0051703607,-0.050491665,0.0040610335,-0.010673344,-0.06379664,-0.07836851,-0.12222722,-0.044789467,0.068975486,-0.05234042,0.06261154,-0.012331638,-0.055855215,-0.010701586,0.07444917,0.06661219,-2.4634039e-08,-0.028646637,-0.021291493,0.07619976,-0.002662258,-0.030534081,0.036136076,0.03987624,0.10222993,0.10738313,-0.032714635,-0.07529146,0.01883318,0.025646077,0.023311835,0.0370709,0.09518533,-0.0490917,-0.13041674,-0.02985507,0.015310341,-0.06332066,-0.08363706,-0.05652501,0.0411077,0.025481494,-0.020747406,0.009406535,0.024348069,-0.0031028455,-0.037297122,0.03337154,0.0623184,0.024073282,-0.021803888,-0.09990164,-0.020326069,-0.012539934,-0.07196786,-0.010561458,0.046083566,0.0016309926,0.075903915,-0.091988154,0.03105199,0.027005145,0.0039907857,-0.0026834398,0.028893964,-0.05503724,-0.10413934,0.04058982,-0.005464684,-0.00921232,0.027002404,-0.088182226,0.028150491,0.027306333,-0.0006973923,0.004361292,0.03347747,-0.041082017,-0.028967533,0.113409154,-0.056561157 +1.3.1.64,Involved in the phthalate degradation pathway in bacteria.,384,0.99999994,-0.048303615,0.0011875039,-0.015898896,0.03483434,0.05639294,0.036397398,-0.02572506,0.040078636,0.0064258003,0.011439813,0.01909553,-0.03721992,-0.04529341,0.07454219,0.020021528,0.0056673023,-0.096922636,0.040702146,-0.0086707715,-0.022657048,0.015384087,0.015971616,-0.046534173,-0.010290982,0.016148297,0.04065938,0.11539945,-0.0960644,-0.021601489,-0.0010511955,0.04652694,-0.037734285,0.020502232,-0.03820198,0.074360535,0.13124241,-0.016190039,-0.0868231,0.09926452,-0.036851432,-0.02189032,0.032121718,0.047726586,-0.06145078,0.031278543,0.042237494,-0.021906909,0.013408223,-0.021510784,-0.07431715,-0.037994456,0.045022417,-0.03344252,0.02723595,-0.008059678,0.026271125,0.024542125,0.0024171767,-0.103039086,0.015137713,-0.015591873,0.0065739667,-0.0022778655,-0.020013189,-0.09141821,-0.054283474,0.07906372,-0.043404553,0.028370885,0.047688443,-0.12616892,-0.037799906,0.020691564,-0.026343657,0.10060928,0.0028347499,0.0360096,-0.042464733,0.019051291,-0.057991557,0.038320784,-0.007699592,0.05710305,-0.026561696,-0.0414712,-0.02251452,-0.008481815,-0.05951126,0.032675106,0.013982006,0.013431492,0.026100807,0.00052632473,-0.014761137,-0.09200261,0.0417302,0.051594652,0.058168005,0.073169895,-0.036888078,-0.0800022,-0.0063090464,-0.09406189,-0.03545866,-0.04826252,-0.0526775,0.027607571,0.111665815,0.017474743,0.052760005,0.013362463,0.036868263,0.0677734,0.017414475,0.03794649,-0.020424565,0.0151498895,-0.033539858,-0.06873512,0.029391497,-0.051075194,-0.08074179,0.03781601,-0.01496815,-0.08119575,-0.06590242,0.027176984,-2.9133e-33,0.07818997,-0.066286325,0.055634543,-0.07475763,-0.01432884,-0.0017278765,-0.08221189,-0.0695178,0.023216475,-0.115633704,0.050731853,-0.09138454,-0.047243804,-0.039692402,-0.0002181952,0.06398126,-0.10502363,0.04159554,0.051709015,-0.054767694,-0.023982074,0.037113644,0.016410816,0.0024402556,0.04542843,0.062303923,0.075529635,0.057784867,-0.11590146,-0.025107944,0.029216992,-0.03742355,-0.15826961,-0.013707799,0.0779766,0.050268434,-0.058021907,0.030189702,-0.020685177,-0.03243794,0.012272466,0.053149663,-0.010740583,0.004823056,-0.03395067,0.0346643,0.002664344,0.101949394,0.0020761648,0.02849104,-0.04236553,-0.016452318,0.055472545,0.05649372,-0.045358177,-0.030442765,0.08170698,-0.102800384,-0.014159514,-0.043237664,0.01609597,0.0751707,-0.066155955,0.035333943,0.04009708,-0.024791988,-0.022891564,0.010782208,0.03888157,-0.00011966341,-0.032603376,-0.047114685,0.02043256,-0.009186528,-0.060340077,-0.034627542,-0.07996767,0.059464537,0.008160107,-0.00556745,-0.0017418766,0.012540757,0.004403428,0.010759926,0.0052797487,0.010014816,0.0024683739,-0.02291013,0.06426249,-0.009972002,0.03360116,-0.13336839,-0.013772311,0.036447663,-0.043381784,5.963577e-34,0.06396542,-0.016682414,0.027022319,0.04188812,-0.029298408,-0.06706772,-0.019345123,0.121058956,0.029815134,-0.046389226,0.019477766,0.05019577,0.06161951,0.055299714,0.06863388,-0.00037333072,0.04396326,0.07879265,-0.03795058,-0.014751656,0.061920665,0.022371909,-0.05528261,-0.01064997,0.018589549,0.04667984,-0.0189717,0.029526621,-0.009090128,-0.0030511036,0.019757014,0.028007763,-0.061862856,-0.030459613,0.030686576,-0.08408138,-0.039816733,0.0014257953,0.0013890513,-0.056542575,0.07040492,-0.032982636,0.03455488,-0.0077837836,0.07955881,0.071410045,-0.04636388,0.0033962845,-0.014921199,0.03036602,-0.027079886,0.012438568,-0.043204557,-0.042837486,-0.039324243,0.024760598,0.020075062,0.048849724,0.044632796,-0.04065504,-0.04453172,-0.019542275,0.060174994,0.070037656,-0.0233052,-0.0038735666,0.049605787,0.07962791,0.095946886,-0.093641125,0.050575178,0.06278883,0.08169065,0.003937119,-0.059242398,-0.08542365,-0.11427714,0.03327149,0.061554287,0.101668455,0.04991153,-0.032524634,0.011701435,-0.0426066,0.020257438,-0.04443903,-0.020433431,0.05448275,-0.030978715,-0.00079487823,-0.014644157,-0.09683132,-0.017672924,0.051558115,-0.006767323,-1.8173733e-08,-0.009664723,-0.018622601,0.038397156,-0.0007612032,-0.010265854,-0.0024703855,0.021637486,0.07356865,0.0910553,-0.0041525993,0.021721093,0.05384235,-0.030908689,0.004435822,-0.046425138,0.035032835,-0.04371684,-0.071969174,-0.025895333,-0.010536844,-0.10090586,-0.08070965,-0.025154967,0.09407277,0.06506904,0.03402694,0.018652216,0.019590382,-0.030546071,-0.07538172,0.04365509,0.020714108,0.07982556,0.042301353,-0.024733523,-0.02408658,0.025979746,-0.022603422,0.019232603,0.08914565,-0.052369118,0.05644093,-0.10564273,0.03854785,0.077280134,0.069413066,0.0044555264,0.052470744,-0.079745725,-0.068393655,-0.007931467,-0.04943813,-0.08471276,-0.03862324,-0.13200484,-0.036103025,0.04079141,0.055090398,-0.0055808765,-0.018536264,0.051765203,0.00455559,0.12158206,0.0036742112 +1.3.1.65,Acts in the reverse direction to form part of the 3-methylquinoline degradation pathway in bacteria.,384,1.0,-0.0043491665,-0.05091682,-0.015126794,-0.032163333,0.043598555,0.0065913843,-0.058024872,0.013341565,0.058270674,-0.009833076,0.017269515,-0.022983465,0.037532814,0.013162578,-0.01935613,0.08215081,-0.17051466,0.028798131,-0.0065001496,0.031304337,-0.020202167,0.0440972,-0.067309394,0.02074232,0.022107674,0.080628015,0.0120026115,-0.017841969,-0.026932549,-0.0076778997,0.0151117975,0.03586614,-0.0028860755,-0.050908487,0.040464066,0.093583085,0.007742596,-0.016795263,0.08882108,0.03178514,0.031225676,0.028443275,-0.028060531,-0.03718691,0.0075262156,0.049076684,0.016543875,0.023424167,0.07221898,0.004027277,-0.057573438,-0.017368203,-0.06429168,0.10128922,0.0062126657,0.062737994,0.013608018,0.02068133,-0.069427386,0.01075141,0.058568086,-0.00700647,-0.0054222634,-0.002346883,0.011585454,-0.010492478,0.015805205,-0.04714318,0.053341378,0.042886775,-0.10988716,-0.09178612,-0.02944556,-0.0146029135,0.02558205,0.08355835,0.038144857,-0.024670286,0.022175003,-0.118154466,0.009565316,-0.0081544,0.07842558,0.057108723,-0.0066273366,-0.091576286,-0.010705336,-0.087739125,0.12105033,0.09223316,-0.03936753,0.021353416,0.0025085085,-0.06859787,-0.026480597,0.014998485,0.035888985,0.01505617,0.08104506,0.0021867575,-0.03651153,0.029598482,-0.09212967,-0.06868644,-0.0051792567,0.01617063,-0.0008036218,0.0630737,-0.039627686,0.0020163457,0.00215571,0.031723876,0.044251706,-0.044270907,-0.0038317423,0.052855935,0.073793836,0.014117585,-0.12046061,0.011443162,-0.10730637,-0.011057033,0.029362468,-0.071488105,-0.07612829,-0.034131616,0.0010374241,-2.5106049e-33,0.05174814,-0.012348463,0.008679799,-0.06094165,0.013652731,-0.0021066044,-0.038507305,-0.0028904604,-0.0023371663,-0.06102633,0.02631195,-0.1272236,-0.013878736,0.027383901,-0.050945427,0.028915368,-0.0652077,-0.0028945312,-0.008194901,-0.070518345,-0.03468079,0.053049494,-0.01593727,-0.114410244,0.025798006,0.021464135,0.04568067,0.03400475,-0.056160595,-0.035430036,0.033150177,-0.07391845,-0.15353192,-0.052696917,0.11742273,0.078406885,-0.031077558,0.002072569,-0.0045750868,0.11228588,-0.018532129,0.034653876,-0.025143873,-0.046766523,0.0084589245,0.021389386,-0.004010165,0.08704221,0.019036096,-0.009205536,0.035391822,-0.034490425,0.056927588,-0.010745347,-0.057616156,-0.055051878,0.05973406,-0.02375387,-0.030712456,-0.055911385,0.018039798,0.017750684,-0.070360444,0.04394507,0.06245333,-0.026378907,-0.054296583,0.027410816,0.023529787,0.0027682646,-0.039865218,-0.0019541061,0.014009404,-0.020356942,0.00575324,-0.023633614,-0.1664653,-0.031627383,0.08510471,-0.040992696,-0.0724323,-0.029536415,0.016669948,-0.035257027,-0.04613006,0.042150147,0.052028704,-0.08102224,-0.02190377,-0.029557273,0.0840187,-0.02514173,-0.007966409,0.03968959,-5.5557284e-05,2.637436e-34,0.0128374435,-0.04067854,0.017109115,-0.0110125365,-0.087038636,0.017007148,-0.049599692,0.068429165,0.0004575816,-0.008485255,0.058347937,0.028757036,-0.015319535,0.02119417,0.020335015,-0.015392543,0.02325384,0.06219192,0.0018983937,-0.077568874,0.05262231,0.044009157,-0.05946474,0.098333836,-0.04184583,0.014768958,-0.007058865,0.04586918,0.094108194,0.054564275,0.009686146,0.03913379,0.012215193,-0.0096539585,0.020621728,0.05886014,-0.040129755,-0.010227733,0.022112343,-0.032817535,0.0693024,-0.028870724,0.0037706278,0.004078436,0.03140236,0.08939316,-0.059826426,0.07898988,-0.015262435,0.014462991,0.04043491,-0.05550146,-0.026134053,0.021102032,0.03124902,0.05340349,0.025647309,-0.035684977,0.031525984,-0.024890075,-0.059970696,-0.03365819,0.04454789,-0.019795716,0.016991593,0.08231935,0.04241871,0.07078367,0.05093889,-0.082510084,0.07817004,0.09929111,0.022332996,-0.013060935,-0.056522634,-0.05455682,-0.024744147,-0.006547374,0.028663954,-0.004147181,0.017001718,-0.025370529,0.016436571,-0.060322408,-0.045304365,-0.06650241,-0.059345122,0.07590764,-0.046692178,0.03399414,0.0017546868,-0.02323159,-0.034586832,0.014492836,0.06381914,-2.2762217e-08,0.05948081,-0.046590064,0.058779135,0.017204573,-0.0062672314,0.042330794,0.018250406,0.111133054,0.112643495,-0.024425343,0.0101807555,0.015914077,0.013858836,0.0021850031,0.0077983374,0.048389245,-0.043477003,-0.045018967,-0.040186025,-0.06284684,-0.13481782,-0.043828797,-0.0304963,0.028552866,0.09115207,-0.038764015,0.014994928,0.09011574,-0.05324357,-0.05172218,0.05228305,0.038018394,0.0005750185,0.0002903681,-0.08947744,0.01164352,-0.014773276,-0.07950001,0.0473846,0.07389721,-0.045960225,0.0986533,-0.13126105,-0.0015274341,0.04381371,0.009417123,0.009371015,0.08869434,-0.08046604,-0.0796037,0.025324745,-0.023224624,0.0760171,0.004945412,-0.11157909,0.00909515,-0.04492227,-0.0037071197,-0.010099626,0.005372651,-0.019250484,-0.013749866,0.13406499,-0.05094326 +1.3.1.66,Involved in the ethylbenzene degradation pathway in bacteria.,384,1.0,-0.052534115,0.0059655122,0.011595488,-0.027251279,0.09596416,0.016149828,-0.02245221,0.09540926,0.028455403,0.006074864,-0.03114921,-0.048610434,0.0067782076,0.032088663,-0.06010029,0.06649519,-0.101207756,0.048570383,-0.05111272,-0.007415744,0.035372324,0.023498887,-0.020370074,-0.028546218,-0.014423452,-0.001640927,0.047931623,-0.030222187,0.023103895,-0.06533122,0.08444495,0.0023432106,0.0014641556,0.0046339743,0.062245138,0.03677939,0.07674166,-0.1008495,0.052341904,-0.03485207,0.0036682857,0.051550027,-0.08470013,-0.05548565,0.020853931,0.029171491,-0.009088828,-0.030655267,-0.014903399,-0.09985729,0.022989187,-0.025076466,-0.0019243852,0.026977485,0.03670461,-0.029514274,0.06949175,-0.016212687,-0.08396765,0.037407756,0.080412805,-0.070566885,-0.026529983,0.032716792,-0.07172978,-0.0069290395,0.11722248,0.017497879,0.012313272,0.07091659,-0.12409087,-0.08733048,-0.004178629,0.053025533,0.022237396,-0.0065592024,0.093930915,-0.09219105,-0.052156184,-0.07814573,-0.021562506,0.007363309,0.08730807,-0.017616218,0.02869684,-0.017969292,-0.010637914,-0.029121306,0.06825998,0.089516714,-0.04860085,0.017327596,0.041259766,-0.040697478,-0.004114252,0.06406193,0.04591893,-0.015032171,0.071431555,-0.013241419,-0.04949984,0.09975624,-0.1204029,-0.08720549,-0.00033157997,-0.00051840866,0.07780858,0.09087714,-0.024672871,0.024323203,0.008359021,-0.034229323,0.015675815,0.025182284,-0.041805554,-0.010895839,0.06844636,0.017368166,-0.0676622,-0.0022073828,-0.06437665,-0.037626173,-0.030608626,0.0074849254,-0.07762146,-0.029129755,0.031666394,-1.9843458e-33,0.007932737,-0.045736015,-0.05788536,-0.05424298,0.09467837,-0.009644583,-0.039310582,0.019957813,-0.0038464575,-0.061146595,-0.027869577,-0.08464779,-0.030006066,-0.06350601,-0.004535589,0.07698094,-0.05911252,0.087140314,-0.018695967,-0.062158003,-0.045585003,-0.036878508,-0.0071741072,-0.04869299,0.044893388,0.045735285,0.08769549,0.063755475,-0.039756496,-0.06334352,-0.038810518,-0.023441318,-0.11904912,-0.0063033192,0.106036305,0.0673522,0.005223008,0.08521639,0.03486936,0.073162235,0.03481517,0.030936077,-0.035263885,-0.02415406,0.021905884,0.00798204,-0.067171864,0.05244435,0.0020013861,-0.014750481,-0.027815323,-0.044189174,0.07415891,0.015521079,-0.0228078,-0.002487674,0.025737848,-0.021958306,-0.00888746,-0.07906224,0.011018401,0.01476302,-0.06367872,0.030410314,0.09412232,-0.0020573023,-0.0674936,0.028531907,-0.02574294,-0.005343813,-0.08541699,-0.02088394,0.040811304,-0.005853566,0.044256497,-0.04352047,-0.13523154,-0.03167319,0.019003553,0.04133017,-0.015113057,-0.005212783,-0.028118555,-0.074737325,-0.022697985,-0.010986428,0.008229056,0.02131483,0.033846136,-0.0008113012,0.14158039,-0.12813585,0.016389972,0.025241734,-0.05374591,2.6581406e-34,0.080727585,0.056692503,0.016981043,-0.009757464,-0.012361702,-0.0015243414,-0.06478828,0.08922202,-0.027089678,-0.002411234,0.052439764,0.007104173,0.0018349052,0.023669044,-0.014764953,-0.003165004,0.056448076,0.016324574,-0.048553046,-0.09345363,-0.04012841,0.021863546,-0.013375215,0.029784828,-0.034318056,0.062712364,-0.006263375,0.06530629,0.0067318734,-0.015189459,-0.010391284,-0.014796241,-0.037651017,0.023203209,-0.024271231,0.06651492,-0.03789908,-0.012785165,0.013658785,0.008421974,0.023574011,0.004416631,-0.029484456,-0.011174754,0.06053169,0.10270465,-0.09125333,-0.0148264,-0.009347717,-0.046659112,0.052516934,0.025361601,-0.03695663,0.02228736,-0.038460612,0.0322417,0.036607433,0.0071151406,0.0036327597,-0.008925469,0.022301355,-0.0027476202,0.025902871,0.086478464,0.011430494,0.016507316,-0.0069196536,0.16027975,0.0054127886,-0.022324607,0.0925267,0.09347948,0.010539989,-0.0013135431,-0.074071705,-0.048012577,-0.02557944,-0.071102954,-0.029743988,-0.03657877,0.022102788,-0.023752851,-0.050298877,-0.025586389,-0.054444972,-0.028056756,-0.040064424,0.0398626,-0.01889435,-0.016868753,-0.00072259153,-0.028660646,-0.042828765,0.08748959,0.05080087,-1.9305746e-08,0.039514463,-0.017046828,0.026214577,0.042257544,0.0072844494,-0.046230074,0.0329075,0.13678354,0.10181497,-0.0028384933,-0.07192553,0.029418817,0.008267943,0.029883558,0.040666435,0.008127339,-0.048077576,-0.019857267,0.030800316,-0.020179851,-0.080696404,-0.02566115,-0.05415825,0.066568,0.04639257,-0.011024752,0.06700244,0.09414215,0.038702633,-0.07764011,0.0002724832,0.05020687,0.039873645,0.07416249,-0.037734292,-0.02254985,-0.012238986,-0.04011821,-0.015494803,0.034729406,-0.011214421,0.065888904,-0.12081323,-0.007114913,0.0743314,0.05948188,0.05086057,0.054728754,-0.047463413,-0.08131867,0.04291723,-0.038088255,-0.005750227,-0.017672865,-0.16440547,-0.020294636,-0.03468141,0.030911215,0.023478843,0.0021096321,-0.02119131,-0.06903188,0.113837585,-0.028977739 +1.3.1.67,Involved in the p-xylene degradation pathway in bacteria.,384,1.0,-0.008478143,-0.021170966,-0.019792842,-0.013607273,0.07886597,-0.0050514103,0.016742151,0.048645306,0.035302218,-0.0017824791,0.024068682,0.061020758,0.032027192,0.108965054,-0.00025764896,0.008304332,-0.15263079,0.029671663,0.003869153,0.04299317,0.09847577,0.04424336,0.00930666,-0.02235098,-0.037431154,0.042829834,0.041420463,-0.05663314,-0.012220795,-0.057794556,-0.033150863,0.03070935,0.056829147,-0.047400728,0.09217646,0.10219592,0.00650139,-0.05706808,0.06547726,-0.058717437,0.04083546,-0.055155676,-0.046022285,-0.06081693,-0.014424409,0.017911805,-0.035272982,0.0019136341,-0.010190518,-0.05596105,-0.008023173,0.008218956,-0.017543564,-0.05423058,0.040243592,0.0011827622,0.014699898,-0.04570302,-0.023065759,-0.043513633,0.08021084,0.0300075,0.057838634,0.033946034,-0.05228198,-0.035532422,0.04968611,-0.040604215,-0.019521033,0.015088178,-0.1548778,0.012821542,0.011286716,0.0047287303,0.043234784,0.038733263,0.02454011,-0.093896545,-0.037243683,-0.048042644,0.04282738,0.00060346106,-0.010188318,0.011842542,0.031037366,-0.053398304,-0.0036367036,-0.009577531,-0.065461755,0.046397936,0.048430186,0.06586186,0.039629567,-0.014631923,0.009328691,0.027932396,0.10474181,-0.04530199,0.03959049,-0.03729858,-0.06513898,0.001789315,-0.031680234,0.0019555222,-0.032659303,-0.073726796,-0.033424336,0.045607686,-0.018196281,-0.0048177196,-0.009137952,-0.028766582,0.01643012,-0.0074671465,0.010140147,0.062098294,0.06565671,0.03520567,-0.03758239,-0.039211504,-0.07401334,-0.08812618,-0.045310866,0.059625007,-0.043174755,-0.025910983,0.0019385808,-2.1775243e-33,-0.0098205395,0.02864841,0.0040059993,-0.0696151,0.06942536,-0.04864959,0.021904005,0.008672596,0.035057303,-0.031064432,-0.0076317387,-0.0746377,0.0029361867,-0.056202788,-0.051649254,0.031443853,-0.082172796,0.06233503,-0.017233804,0.0016638477,0.0010962163,-0.030958738,-0.0037677742,-0.009836537,0.04595493,9.24474e-06,0.023562122,-0.033470962,-0.05123868,-0.07478359,-0.030452847,-0.05235687,-0.06687638,0.024049032,0.03076689,0.029103719,-0.06355926,-0.04389803,-0.009801394,0.005333127,-0.039918456,-0.027756853,0.051244877,-0.05061365,-0.045968942,0.04157572,-0.0633247,0.0710002,-0.029440371,0.010334484,0.05643637,-0.018823836,-0.017318187,-0.008668435,-0.020629935,-0.026071029,-0.006717529,0.012940673,-0.016828086,-0.014604796,0.122419655,0.0112984385,-0.0602797,0.01447053,0.05248555,0.048620716,-0.03463328,0.006913384,0.030775512,0.043585707,-0.10198856,-0.043448776,0.0336175,-0.060065,0.023355192,0.036519554,-0.12957293,0.06965125,0.08612006,0.030090954,0.04119659,0.024215091,0.016996594,-0.043791186,-0.053945646,-0.023686351,0.029441545,-0.017074348,0.06554998,0.07241082,0.08953266,-0.13042246,-0.045719363,0.056440674,-0.012836554,7.597062e-34,0.07655279,0.005811711,0.056219563,0.039076332,-0.04448581,-0.020116888,-0.011239222,0.020620085,-0.007642132,-0.060011014,0.0698522,0.075101726,0.021533249,-0.0008521275,0.041810803,0.028270703,0.09649539,0.020759165,-0.06093597,-0.031533986,-0.040189855,0.057546232,-0.0027191713,-0.016493803,-0.029902548,0.017236043,0.033022605,-0.0073576984,0.083542645,-0.023744844,0.01783643,0.040175736,-0.054197058,0.00048138347,-0.0026427729,-0.08952464,-0.038015794,0.0065087616,0.0767856,-0.0077192443,0.06304448,0.02754765,0.022048105,0.030266559,0.014118776,0.122919895,0.001727278,-0.0628739,0.06393113,0.012202823,0.005013497,0.061155066,-0.08618978,-0.008105889,-0.044927303,0.059023105,0.004102258,0.04137382,-0.013048154,0.006614504,-0.09961511,-0.06305581,0.08836056,0.034576327,-0.019590423,0.0062669143,0.038515296,0.106846154,0.027878618,-0.07126908,0.103352964,0.07093049,0.0053883204,0.038392846,-0.103117526,-0.0064631673,-0.06702716,-0.038284715,0.045360588,0.014133593,0.021401646,-0.021577122,-0.10725215,-0.06385235,0.017287927,-0.030344917,0.010421454,0.08420286,-0.0012718819,-0.07013201,0.048877016,-0.056916982,-0.00813667,0.020722752,0.11241094,-1.7010409e-08,-0.06878385,0.016285507,0.042488817,0.01916327,0.04179972,-0.0022703987,0.07781129,0.09494826,0.1161443,-0.051235385,-0.040051386,-0.03618421,0.0075852424,-0.025402451,0.014759742,0.02287284,-0.0773625,-0.054030288,0.02935469,-0.07895854,-0.11635603,-0.09476864,-0.10699157,0.046926882,0.0427449,-0.030245801,0.10678096,0.023097202,0.053290136,-0.13058648,0.006921519,0.010990715,0.018693576,0.044674724,-0.0015001482,0.016250076,0.015706329,-0.07125115,0.053777326,0.054279745,-0.04335615,-0.008647433,-0.08621011,-6.404044e-05,0.05285368,0.114188075,-0.02980917,0.044948883,-0.09798473,-0.06930944,0.079493344,0.00019011117,0.0013055541,-0.055048298,-0.05688289,0.044475857,0.053016193,0.060373344,0.012569518,0.002632107,-0.022661733,-0.054949813,0.13510013,-0.029238855 +1.3.1.68,Involved in the o-xylene degradation pathway in bacteria.,384,0.99999994,7.6637e-05,-0.011797615,-0.034623194,0.019830007,0.107106656,-0.05228143,0.011295003,0.03894142,0.057051543,-0.039547678,0.022155479,0.06074471,0.029585248,0.076159045,-0.023000024,0.04898667,-0.12058351,0.050096452,-0.047340874,0.05835346,0.11452742,0.041949023,0.006704283,-0.031935073,0.00033934112,-0.0057378965,0.00878073,-0.052087463,-0.016565258,-0.09382845,0.019864837,0.033527143,0.067253634,-0.06243388,0.09328415,0.05760911,0.08810717,-0.11282547,0.035384353,-0.0112383,-0.002124523,-0.0187334,-0.041590218,-0.049870376,-0.024464913,0.005009767,-0.009142182,-0.037650097,-0.010625103,-0.018849703,-0.019630594,-0.015684085,-0.038484,-0.039590374,0.035173118,-0.0024895712,-0.015362685,-0.063690916,-0.03189582,-0.0026990022,0.084838755,0.024164,0.07997226,0.03383361,-0.06040965,-0.040691208,0.035979733,-0.058452465,-0.04672493,0.014586152,-0.13978578,-0.0017435385,0.039192043,0.021328816,0.052650806,0.04123096,0.043076873,-0.08567463,0.015974743,-0.042369906,0.021064594,0.0100762965,-0.009349646,0.020500852,-0.024628326,-0.040253285,0.012907918,-0.008157599,-0.024689341,0.0785035,0.009332731,0.059533283,0.0464098,-0.07475954,0.029324403,-0.003290125,0.16297995,-0.023317939,0.017633667,-0.021253716,-0.0864715,0.002437122,-0.034036294,0.01753958,-0.022701498,-0.080975495,0.00053663447,0.06368045,-0.0318878,-0.009584584,0.031812076,-0.048079666,0.040343974,0.008769154,-0.024272276,0.05086491,0.036940873,0.009129977,-0.064641654,-0.015871735,-0.07605661,-0.10634452,-0.051414322,0.072757415,-0.030125534,-0.00040703118,0.018209897,-2.4903364e-33,0.009489171,0.036802277,-0.0052735256,-0.09541855,0.05026167,-0.07057267,0.019237716,0.018854925,0.05553063,-0.026317952,-0.010888586,-0.043821108,-0.001304326,-0.060295798,-0.0156228,0.013204216,-0.06196399,0.039897032,-0.03681302,0.02195339,0.0236319,-0.020364793,-0.0059244726,0.00802057,0.03556891,-0.004498455,-0.0010992868,-0.077986546,-0.040483624,-0.053543247,0.0031436768,-0.07649556,-0.08049805,0.052319977,0.054494143,0.031194078,-0.058547106,-0.047168955,0.02329098,-0.005166518,-0.034854148,0.02518118,0.04201857,-0.042202882,-0.033099532,0.049032483,-0.049093466,0.067420155,0.001549823,0.0076238294,0.015773391,-0.012179984,-0.026396224,-0.014129273,-0.0012303662,-0.033650197,-0.0524633,0.0070240935,-0.014378107,-0.0065248045,0.05749166,0.0037305532,-0.055139195,0.02931516,0.017963754,0.021626823,-0.059721585,-0.0121358475,0.04315139,0.025544979,-0.08484464,-0.061273243,0.011263847,-0.04898617,0.0041167825,0.05796093,-0.12449748,0.051801007,0.08937683,-0.011862339,0.07324345,0.01977428,0.021636436,-0.06497765,-0.048262674,0.014471326,0.021385176,0.021273727,0.04747409,0.11940958,0.07209363,-0.13431074,-0.034901008,-0.0063095447,-0.019454807,1.1410576e-33,0.08349629,-0.012072727,0.06197166,0.026546502,-0.051421713,0.008259458,-0.06246888,0.044398207,-0.0079803765,-0.06657422,0.05261776,0.098521136,0.04057382,0.0056767226,0.029631292,0.0025495687,0.08333168,0.02878402,-0.06807079,-0.036696862,-0.06877406,0.03792755,0.013951825,-0.035319492,0.009371581,0.035908736,0.000584075,-0.019401997,0.07801388,-0.0057574576,0.02181166,0.032666508,-0.022019226,0.019920811,0.038831916,-0.06410617,0.0077972505,-0.014108947,0.049162716,-0.018217448,0.030291094,-0.035768095,0.027425831,0.022377653,0.0045682634,0.12904747,-0.051060244,-0.01261898,0.06594204,0.013737327,0.02047339,0.01817936,-0.09980554,-0.022490617,-0.064012796,0.07187246,0.04062991,0.012983532,-0.03442507,-0.0051555373,-0.060225006,-0.050416782,0.09612101,0.018168626,-0.019045394,0.018687718,0.04520576,0.10885177,-0.0034410974,-0.08229681,0.077887155,0.0484873,-0.0053813565,0.0027913954,-0.069141306,-0.0012933961,-0.07361307,-0.053125322,0.031180106,0.010376485,-0.036889076,-0.006054012,-0.064341426,-0.045678474,0.025862273,0.019221831,0.01269964,0.10345055,-0.007811717,-0.031285733,0.025222927,-0.076847844,-0.039986867,0.03565118,0.11272914,-1.699709e-08,-0.06006051,-0.0038990376,0.06615734,0.016838891,0.02807139,0.007966883,0.0781776,0.110434674,0.12954013,-0.011264872,-0.018126504,0.023929182,0.014338255,-0.04712808,0.021998147,-0.011818963,-0.045498844,-0.060947694,0.016246974,-0.0662837,-0.11246212,-0.08852896,-0.071405955,0.08665342,0.014691278,-0.05276472,0.110937886,0.043692272,0.075426735,-0.12788656,0.008643162,0.0121271,0.032091822,0.02997927,-0.0471471,-0.03150705,0.031518824,-0.057339977,0.050848257,0.06452662,-0.03678638,0.033360645,-0.07613279,0.00091512466,0.07393713,0.10969313,0.006716932,0.034465298,-0.09953703,-0.06661152,0.044322778,-0.030185927,-0.007587595,-0.0078113168,-0.09158971,-0.02717147,0.032742277,0.047582846,0.01487817,0.039154507,-0.028828284,-0.017303789,0.15497383,-0.048282105 +1.3.1.69,Previously classified erroneously as EC 1.1.1.242.,384,1.0,-0.04684279,-0.021624459,0.012118273,0.030406639,0.03553154,-0.034913782,0.021221327,0.01974127,-0.026220798,-0.03490949,0.049700957,-0.036214225,0.012377852,-0.04196354,-0.070156336,-0.13736545,0.022371763,-0.09924499,-0.01037876,0.06922395,-0.00033418683,0.08970567,-0.032338005,0.043642435,0.045198362,-0.01918737,-0.019302884,0.038404476,0.014887877,-0.11745769,0.04176305,0.038369697,0.0709839,0.021020152,0.042991538,-0.011829439,-0.0022480267,-0.12396809,-0.009913383,0.05115932,0.040971454,-0.016480774,0.034526005,-0.02357853,0.009728491,-0.0151125,-0.051124867,-0.0027760277,-0.05541783,-0.019979069,0.0802569,0.014196946,-0.018836884,0.0292126,-0.005337227,-0.018054314,-0.055978015,0.03232532,-0.024756653,0.01090575,0.040301487,0.0076816496,0.09417371,0.014818931,-0.027765766,0.028131763,0.04936555,-0.13220665,0.05151564,0.017216371,-0.07174482,-0.040265046,0.027806291,0.105941005,0.03666927,0.04699985,0.0097733885,-0.0053097554,0.09587314,-0.050238904,-0.04437144,-0.060918897,-0.09639709,-0.071360126,0.030284446,-0.001511783,0.024480697,-0.029881576,0.010547788,1.1600024e-05,0.017021,-0.1344718,0.112810336,0.045244843,0.0016750626,0.02268437,0.0052935802,0.11872973,0.03212197,-0.010891689,-0.042070296,0.08663915,-0.071738176,0.04336675,-0.042866725,-0.028427606,0.08926153,0.0428722,0.01413094,-0.07878858,-0.032939266,-0.11871128,-0.03249444,-0.09542522,-0.011607854,-0.03594258,-0.02743694,0.031856168,0.06026035,0.034782503,0.031789772,-0.01037856,0.023489816,0.026957413,-0.032533713,0.026401546,-0.0922866,-3.119243e-33,-0.0047343518,0.02771854,0.036541454,-0.021315245,-0.010475673,0.06787703,-0.081657425,0.07342647,-0.0067360476,0.008777714,-0.003356919,0.09814635,0.041838054,0.01962182,-0.007540921,-0.011431255,-0.02826122,0.054475747,-0.029570837,-0.05535317,0.017284349,0.005274638,-0.0067146653,-0.041167695,0.0017973012,0.07443986,-0.042365275,-0.03487611,0.07069297,0.039021716,-0.0024038907,-0.06010539,-0.006215765,0.013624764,-0.03647816,-0.0010163747,0.039559484,0.03208875,0.001816922,-0.035361107,-0.016354624,0.0782546,0.005677338,-0.043676548,0.055268105,0.00085342524,0.013037368,0.077782474,0.08242975,-0.0069319084,-0.08850967,-0.055481773,0.08523251,-0.025161145,0.054815978,-0.04530563,0.0026677218,0.064607404,-0.046889573,0.028786976,0.06312053,0.14580679,-0.03299942,-0.007439408,0.010909583,0.022617016,-0.041247427,0.005050039,-0.019326456,-0.059002787,-0.08362672,0.027394865,0.019046457,-0.0020220184,0.05324693,-0.06440488,0.008249116,-0.0127735445,-0.029730458,0.014995739,-0.14941265,0.016712263,-0.01162337,0.020871473,-0.065051585,-0.0002231622,-0.008811668,0.07310484,0.053453844,0.113526694,0.056682725,-5.2948184e-05,-0.04100268,0.02475964,-0.05373106,1.5613338e-33,-0.05612781,0.036561657,-0.08487342,-0.015601698,-0.024267994,0.043264054,-0.0045298645,0.046287328,-0.02882827,-0.0068885777,0.10942786,0.02127634,0.021246599,-0.07457261,0.027459485,-0.033111263,-0.12512447,-0.040986747,-0.01540524,0.12800272,0.0111652855,-0.0043415218,-0.014085766,0.0623996,-0.0013203297,0.09129031,0.055635437,0.004937132,0.039425,-0.0502393,-0.07506629,0.04468844,-0.10130122,0.07616809,-0.05980531,-0.060747173,-0.0043059546,-0.037884045,-0.030112755,-0.04410278,-0.041150454,0.045405615,-0.100756824,0.056563243,0.048518267,-0.0048909653,0.11133673,0.07799554,0.05686619,-0.025488656,-0.06500478,0.02189032,-0.01708592,0.06505278,-0.012335533,0.023628088,-0.103259005,0.09378776,-0.003431672,0.06788289,0.05334043,0.06306048,0.032441266,0.028506512,0.018062154,-0.07793386,-0.07905729,0.059643153,-0.031313352,-0.014158161,0.08041234,-0.02459409,-0.046356812,-0.08332303,-0.021987002,-0.03353394,-0.076106995,-0.065718316,-0.026109556,-0.040108867,0.00724198,0.04751842,-0.002264042,0.018852292,0.031128887,-0.028612947,0.06057459,0.027187927,-0.003730654,0.014022391,-0.029441757,-0.03950589,-0.09842388,0.082925364,-0.0572077,-2.3037888e-08,0.011539421,0.08602159,0.03302966,-0.017700678,0.10668461,0.040054783,-0.013079756,0.016687859,0.014497626,0.00058506004,7.5374766e-05,-0.015882932,0.017635755,0.0020649945,0.049209498,-0.04363143,-0.0860731,0.08483687,0.0010221169,0.06131683,-0.0042874725,-0.03275855,-0.04392609,-0.10987568,-0.030544724,-0.07063381,0.037220456,0.051999595,-0.005541585,-0.062175825,0.0065581743,0.021368643,0.001859943,0.0028838662,0.023328451,0.04911813,-0.049242318,0.05575261,-0.06676144,0.021547649,-0.048134845,-0.03807786,-0.046324085,0.049248148,0.06686514,0.037917532,-0.014495004,-0.011524571,-0.0050646453,-0.080881126,-0.037224453,-0.0058515724,-0.00349146,0.020697616,0.0010549357,0.0009927663,-0.050704468,-0.053184163,-0.03898431,0.06382219,0.01725984,-0.032110274,-0.0092311725,0.041526344 +1.3.1.70,This enzyme acts on a range of steroids with a 14(15)-double bond.,384,1.0,-0.04089212,-0.0029169414,-0.09920643,-0.050054498,-0.022245502,-0.016621111,-0.07960803,0.075650245,0.01538799,-0.042907678,0.06911795,0.007789234,-0.11354152,0.08488134,0.00028990125,0.067856595,-0.021792082,0.014442787,0.029494831,-0.03328523,0.086671844,-0.03044358,-0.0117707625,-0.020945812,0.04048096,0.053575628,0.059633072,0.0028923042,-0.048106052,-0.06191303,0.03565391,-0.082828194,0.04887313,-0.030945659,-0.0061052,0.044756815,-0.07827024,-0.088091865,0.039798625,0.031434324,0.05179047,-0.0074728713,-0.049098235,-0.047391072,-0.023228507,-0.10364225,-0.06569176,0.047090974,0.05837244,0.013470087,0.021325242,-0.080967635,0.024370082,0.09301598,0.035657693,0.036456265,-0.1622131,0.040157855,-0.044487998,0.0393002,0.07548509,-0.002215258,-0.053901847,0.043834332,-0.02317269,-0.041157667,-0.012600796,-0.016146181,-0.024446042,0.00062512304,-0.009620665,-0.04689122,-0.009530112,-0.019614996,-0.00615679,0.00222812,-0.064371675,-0.026665613,0.06743265,-0.016782645,-0.00237221,-0.043872103,0.0337163,0.08618852,0.0749111,-0.013239992,0.029870044,0.047426,0.030712198,0.09030896,0.010718622,0.02316949,-0.015082215,0.017509352,-0.106370226,0.05019766,-0.03291631,0.027991533,-0.08774784,0.011350612,0.048311945,0.05727667,-0.036666613,-0.053653445,-0.048260517,0.012898148,0.019016111,0.00494345,0.0077074794,-0.023337502,0.045477547,0.053321905,0.0752817,-0.021559816,0.011258353,0.11502221,-0.027946072,-0.011250398,-0.040045876,-0.0403412,-0.0065524,-0.04362264,0.008227185,0.07538955,-0.044662766,0.017281035,-0.11181423,-3.9273964e-33,0.113049,0.024884894,0.02072351,-0.0316699,-0.041102465,-0.0025851098,-0.019522473,0.044940896,-0.094398245,-0.034982916,-0.044941645,-0.065567076,0.08600549,0.03464105,-0.028511776,-0.043940093,0.08691817,0.048701853,0.140974,0.0136159705,-0.025559723,0.06811908,-0.071612075,0.020468485,0.00900962,0.03204133,-0.048423953,0.048827734,0.007628453,0.015198225,-0.035780217,-0.0024920076,-0.05588461,0.034627315,0.04615812,0.028270327,0.026897684,-0.056752075,-0.0020075392,0.0060001747,0.07676202,-0.011005145,0.022340167,-0.007817535,0.0868208,-0.031302623,-0.08766137,0.05675184,0.08711639,0.040469546,0.044267483,0.024944346,0.044699684,0.0072088456,-0.07465223,0.12824343,-0.017659627,0.0019289373,0.03495846,0.06600423,-0.026182333,0.012468714,-0.046992086,0.032480393,-0.072855696,0.08769758,-0.044502612,-0.120150685,-0.05716589,0.14721337,-0.06281929,0.051562276,0.032881066,0.00025207776,0.03386762,0.0211632,0.010426034,-0.01410593,0.046042085,0.062148906,-0.081012964,-0.054645333,-0.010154205,-0.05282142,-0.071684405,-0.042766422,-0.031255234,-0.0752937,0.037394747,0.06853116,0.054929852,-0.080879375,-0.088257276,-0.0002097366,0.024989316,2.0440267e-33,0.078609444,-0.07978229,0.058348466,-0.054505464,-0.013168968,0.06131451,0.009237862,-0.039653562,0.020812863,0.032794587,0.06276687,-0.03300675,-0.021945436,-0.034139063,0.0283307,0.051394865,-0.065567285,0.028885366,-0.025154412,-0.037365768,0.00025032734,0.122416064,0.04688711,0.10690511,0.0044121253,0.016712278,-0.014193103,-0.0063664652,0.037548352,0.04998083,-0.013931958,-0.06361435,0.010820627,0.032616373,-0.015152156,0.09269345,0.005646577,-0.05809174,0.026565254,-0.03306107,-0.021056166,-0.037493132,-0.020928264,0.09484431,-0.00087116135,0.039429843,-0.01807515,0.03313205,-0.035538692,-0.07688336,-0.0019132799,0.019989517,-0.013122629,0.03083083,-0.014953741,-0.01960527,-0.032740146,-0.004874087,0.022707637,-0.050607562,0.033818137,-0.06456918,-0.012692453,-0.023276184,0.014018142,-0.00028206024,-0.056319043,-0.043612707,-0.03991421,0.016578292,0.00799687,0.00023369052,0.0067611896,0.076512665,-0.046479996,-0.07699726,-0.01578753,-0.11995038,0.0049148384,0.01039101,-0.06622436,-0.004449546,0.01849577,-0.07738814,-0.021154268,-0.025681997,0.045113716,0.09392828,0.026493879,0.09712587,-0.033038396,0.061687436,-0.08967578,0.041264907,0.013954473,-2.061537e-08,0.025547843,-0.050940007,0.037001293,-0.03602427,-0.0011196504,0.042823747,-0.011339759,-0.003746781,0.07088954,-0.02871378,-0.026602877,0.08230677,0.010831003,-0.0011762114,0.017252905,-0.034469448,-0.0071496293,-0.0044823224,-0.044264894,-0.067509525,-0.071081206,0.039488114,-0.049213015,-0.019358465,0.021181323,-0.06367264,-0.058260705,0.1266723,-0.032868378,-0.0038297803,0.084148936,-0.02836349,0.024125487,-0.0073568095,-0.051654864,0.09158123,0.0048685963,-0.023282055,0.026224393,0.078539774,-0.03769351,-0.096442685,-0.035951115,0.06798727,-0.033998985,0.0050426843,0.005630594,-0.02445171,0.004097651,0.011434035,0.027717128,-0.009413176,0.019052748,-0.062083054,-0.064113714,0.011828196,-0.040658176,-0.059050377,-0.013049094,-0.055632796,0.032222774,-0.03581534,0.14779767,0.0002245938 +1.3.1.71,Acts on a range of steroids with a 24(241)-double bond.,384,1.0,-0.025747351,-0.023663921,-0.107647054,-0.07707135,-0.13261189,-0.010355311,-0.02908473,0.08122993,0.0047383667,0.0070504933,0.039188,0.037612166,-0.05806018,0.019196229,0.0435533,-0.019285431,-0.010753795,0.028639223,0.01677142,0.073810995,0.0705134,-0.0026277953,0.030737076,-0.029130215,0.007084452,0.067757554,-0.028559051,0.0030900398,0.015917765,-0.03247586,0.06138346,-0.014655203,0.023332639,0.00093486416,-0.046745833,-0.022928046,-0.07774331,0.014235417,0.09138359,0.010897704,0.060007732,-0.03034121,-0.0030823105,0.038270324,-0.03463289,-0.08333095,-0.122723185,0.025799017,8.1334736e-05,0.0023707766,0.07639881,-0.050613053,3.4103991e-06,0.109500796,0.05144656,-0.025904939,-0.1456805,0.053337153,-0.027084002,0.046991706,0.103874564,0.020830972,-0.019417752,0.041132763,-0.033202548,-0.01449614,0.011260489,-0.008522628,0.02269272,-0.018686013,0.04380962,0.030790376,-0.013098307,-0.0214711,0.00033084807,0.023920497,-0.05438826,-0.025337989,-0.004017184,-0.03752917,-0.0053142267,-0.045193326,0.040179502,0.06798829,0.0870608,-0.038707845,0.018905038,0.042170607,0.026090715,0.07338786,-0.023197679,0.032952506,-0.032682043,0.007889974,-0.15156457,0.05362167,-0.030606601,0.04652946,-0.07268023,0.06759234,0.07658449,0.059499588,-0.06018254,-0.023295145,-0.0027072784,0.020310443,0.018370328,-0.03962095,-0.054853566,-0.027842361,-0.002231088,0.019590639,0.037752915,0.0033780523,0.038918503,0.05333217,-0.06689832,0.07588508,-0.00024226634,-0.095345825,-0.009394088,0.011349014,-0.03595477,0.018843204,-0.051745363,0.037744466,-0.0957597,-3.608744e-33,0.05228463,0.02340334,0.0547113,0.060170814,-0.07008061,0.064801656,-0.046738174,0.018924253,-0.04377629,-0.0022827475,-0.045866247,-0.06260307,0.108304545,0.055905122,0.01960385,0.0024149744,0.07587612,0.07466065,0.12218507,-0.024244636,-0.043723695,0.12296524,-0.06987743,-0.0032565123,0.0037242952,0.021854566,0.009265094,-0.045674738,0.023367189,0.043255795,-0.081706405,0.052724916,0.019744918,0.043749947,0.03730371,-0.015240755,-0.066961974,-0.025977354,-0.04290853,-0.0058826637,0.05132232,0.072577305,-0.04673538,-0.068439595,0.014669312,-0.049802843,0.012261475,0.059914876,0.056640822,0.019819738,-0.00380857,0.012619304,-0.009991604,0.05881147,-0.04739276,0.057695817,-0.02510679,-0.030883746,-0.041717518,0.113439545,0.024992712,0.017688958,-0.023068838,0.03734533,-0.10863926,0.040376443,-0.07072711,-0.112642415,-0.06621092,0.101626694,-0.046707995,-0.008510946,0.032363545,-0.08156693,0.0021801775,-0.0022333255,0.075489976,-0.010528826,-0.0024287659,-0.0113568865,-0.07933921,-0.023227593,-0.0008353494,-0.028734423,-0.059083674,0.022055902,-0.03084509,-0.043798506,0.04960388,0.15273158,0.046253704,-0.1218535,-0.10482788,-0.07712143,0.011273277,2.031835e-33,0.019003322,0.013947201,0.005777421,-0.054659467,0.06262665,-0.010725213,-0.04188332,-0.020228865,-0.02099881,-0.007313072,0.064488865,-0.02289499,-0.014610338,7.796538e-05,0.01852132,-0.021721119,-0.012074839,-0.0024316686,-0.0027221558,-0.057849254,0.030975165,0.07050688,0.051636666,0.14398159,-0.017535757,0.07106969,0.006833191,-0.020489305,0.021887468,0.050856795,-0.048000623,-0.025036214,0.008644488,0.0530228,-0.025232943,0.10259981,0.0597852,-0.031164594,-0.002785943,-0.07802217,-0.027112097,-0.0063948906,-0.0064352998,0.12083751,0.026685737,-0.004316639,0.041676063,0.0670888,-0.008375067,-0.03313459,-0.023717096,-0.036238305,-0.064196125,0.019916583,-0.007908782,-0.08720624,-0.055608843,-0.031381268,0.024977025,-0.012883249,0.07985903,0.0013108182,-0.046401985,-0.0054046544,0.0144056585,-0.0320992,-0.048342053,-0.023015104,-0.04334647,0.023704473,0.03346073,0.01349392,-0.056661244,0.0003876238,-0.021918429,-0.068271995,-0.008152791,-0.122147545,-0.009074939,-0.0028495651,-0.11707176,-0.010274746,0.019949589,-0.009585096,0.004907899,-0.0035415138,0.03940771,0.041463587,-0.02760427,0.05011402,-0.04711615,0.07306962,-0.06261678,0.05290573,0.020934949,-2.0789042e-08,0.012221171,0.0013929137,-0.050419297,0.0029502339,-0.08213419,0.049284726,-0.025984295,0.031033598,0.06649469,0.024034435,0.019540848,0.05348165,0.05861676,-0.0076971627,0.010514454,-0.030055102,-0.060118016,-0.026036054,-0.102852955,-0.003811449,-0.026433978,-0.035687856,0.0069970773,-0.0027205523,-0.037424,-0.04004818,0.004537961,0.07969721,0.015258626,0.019333173,0.11581372,-0.080171406,-0.02030267,-0.01017695,0.027622877,0.05403425,0.036927998,-0.014143247,0.043460287,0.081522174,-0.05839766,-0.08746493,-0.06381678,0.14189632,0.022779102,-0.034369897,-0.037157252,0.012616209,-0.0063565294,-0.022155557,-0.028852528,0.034085184,0.027681326,-0.03434743,-0.057973832,0.027313715,-0.047661833,0.0076926127,-0.01317634,-0.007970375,0.027086172,-0.12257384,0.086936,0.017274175 +1.3.1.72,"Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol.",384,0.99999994,-0.06194145,-0.0071481774,-0.03523636,-0.06551565,-0.090878375,-0.02458111,-0.07488411,0.08341942,0.004409836,-0.0037344052,0.029615106,-0.024799492,-0.022119654,0.006275265,0.016451709,0.0009251532,-0.025843052,0.062302254,0.013224696,0.03700783,0.09227,-0.04082033,0.018678881,-0.015093108,-0.008630217,0.056587417,-0.020211115,0.08015901,-0.009053164,-0.10425565,0.03470331,-0.016947262,0.030280419,-0.010596084,-0.06234749,-0.025682105,-0.08907576,-0.029957812,0.11956332,0.028566092,0.07255146,-0.047381245,-0.014965858,-0.000780948,-0.036106575,-0.06708532,-0.11714597,0.06834559,-0.006266317,0.0378929,0.014314017,-0.087481365,0.025531447,0.11516817,0.04357556,0.07022604,-0.12087942,0.033942472,-0.020283857,-0.020911835,0.10973529,0.021322766,-0.05565359,-0.004864777,-0.056022447,0.044188622,-0.0074062296,-0.023785917,0.035903305,0.02942487,0.011783253,0.013013164,-0.01470379,0.01272335,-0.053354826,0.07280464,-0.031053029,-0.077507935,-0.03942234,-0.039872926,-0.015213295,-0.0084811775,0.057366904,0.04275339,0.11136082,-0.015373418,0.013661624,0.016043132,0.0053013,0.048477065,0.010390967,0.03873561,-0.055421036,0.010271839,-0.11752089,0.0087502785,-0.015203027,0.08606825,-0.1194929,0.0267417,0.08054067,0.057399083,-0.04714181,-0.06023586,-0.035919,0.012044853,0.027638867,-0.060954023,-0.10575647,-0.06664005,-0.047127385,0.0046230033,0.024914691,-0.0154984845,0.0052694282,0.06252704,-0.021356028,0.040520344,-0.004816178,-0.07049641,0.0029900786,-0.009611855,-0.025357472,0.03451093,-0.044381138,0.02773114,-0.06759649,-2.5268565e-35,0.021691632,0.029280687,0.0207629,0.09306127,-0.065385655,0.047335435,-0.025449473,0.032942697,-0.075292856,-0.06304492,-0.0344638,-0.01785832,0.11953267,0.040939655,-0.01263306,-0.038369205,0.104357004,0.059896324,0.11369813,-0.04147412,0.0006297229,0.15273632,-0.08125132,-0.036168266,0.011331471,-0.013671668,-0.011247582,-0.041597433,0.009696196,0.037376445,-0.07860766,-0.01410373,0.016509082,0.040820763,0.06428019,0.06546308,-0.038953505,-0.023658654,-0.01912825,-0.011147513,0.05182804,0.010825578,-0.048509277,-0.025799617,-0.020455146,-0.027022682,-0.056561418,0.013746099,0.036093492,-0.023363745,0.040797472,-0.0038033698,-0.04955974,0.060954567,-0.068789214,0.06784952,-0.039594907,-0.023551641,-0.013129358,0.10095705,0.016968809,0.009317229,-0.016144596,0.04385913,-0.021759491,0.051058277,-0.0901843,-0.10031383,-0.08734738,0.08890828,-0.017491661,-0.01105085,0.062605396,0.0030405477,0.033840373,0.0559342,0.028698787,-0.04821575,-0.001722635,0.03312588,-0.09355119,-0.038826916,-0.03913757,-0.052298132,-0.038784605,0.00978521,-0.018149272,-0.03081362,0.06033095,0.12060905,0.028459255,-0.14491636,-0.08418403,-0.028903807,0.014310992,-1.4664911e-33,0.007304555,-0.022335816,0.026920825,-0.028315915,-0.0016284968,0.05960652,0.0009159317,-0.063686326,0.018458012,0.025685506,0.11423083,-0.014264668,-0.053329125,-0.019149063,0.0082094995,-0.010876285,0.007457983,-0.03343238,0.017855037,-0.021726688,0.050992098,0.07719058,0.049009655,0.13820201,0.02328456,0.07757096,0.072138354,-0.018582156,0.024061708,0.060708053,-0.02700073,-0.023365805,0.06567723,0.009224522,-0.037847802,0.106738456,-0.025084298,-0.042501993,-0.003286838,-0.057469178,-0.099902615,-0.03570971,0.013824626,0.087428115,0.07784291,-0.05174935,-0.014961073,0.02187939,0.006263671,-0.015663635,0.02714044,-0.016676808,-0.06042074,-0.0008909523,-0.0013571959,-0.030318337,-0.051246922,-0.02287531,0.056179255,-0.044245113,0.038538646,0.0027695314,-0.04963037,-0.069928214,0.051883347,-0.011476077,-0.023293303,-0.015093672,-0.021589708,0.007597493,0.030051455,0.06100415,-0.023089532,0.0046929726,-0.055152837,-0.041705143,-0.015894717,-0.06474592,-0.011356644,-0.010411175,-0.12299026,-0.03209775,0.031818897,-0.0036471991,-0.027588021,-0.036584485,0.050205696,0.0547538,-0.011948418,0.04406624,-0.015833942,0.022316467,-0.064517796,0.056658287,0.030097883,-2.972456e-08,0.049584832,-0.03417712,-0.05848188,0.030404167,-0.06331326,-0.015053726,0.003754003,-0.038194876,0.08717731,0.009981144,0.019022005,0.07252177,0.06333057,0.006488922,0.030770523,0.00095211534,-0.0406828,-0.0035660078,-0.042718865,-0.022771122,-0.018612329,-0.011684782,-0.008599587,-0.009743937,0.02490087,-0.04418171,0.026465224,0.060126822,0.020387966,0.011039934,0.11853935,-0.071886376,0.011684684,0.030613748,0.07026546,0.108852245,0.012194019,-0.037792146,0.0008986646,0.08599733,-0.07279252,-0.08643654,0.0008328928,0.1048128,-0.029006647,-0.05584489,-0.0009407814,0.016923254,0.02186339,-0.026965028,-0.07357584,0.014785725,0.029455148,-0.015167498,-0.060285628,0.09317225,-0.027764745,-0.0190199,-0.034796495,-0.019104818,0.010330544,-0.072565645,0.09758428,0.039190754 +1.3.1.73,"The enzyme, characterized from the plant Rauvolfia serpentina, participates in the ajmaline biosynthesis pathway. It has a much lower activity on vomilenine.",384,1.0,-0.056142036,-0.009637406,-0.118976474,0.014017505,0.02495042,0.029394075,-0.108205125,-0.001046863,0.033205997,-0.073797226,0.031736907,-0.029181976,-0.0058158548,-0.052289445,-0.10535348,0.06743429,-0.0018276972,0.07009998,-0.079235025,-0.07026222,0.075398214,0.048184674,-0.022797633,-0.05543145,0.038591556,0.029560635,-0.039698243,-0.020190723,0.045624305,-0.05012518,-0.0056503606,0.009009219,0.056308664,-0.06642036,0.040275246,0.048749145,-0.07275489,-0.037897862,0.071648635,0.04023349,0.026947748,0.036800697,-0.045120697,-0.0120351035,-0.08639845,-0.050962754,0.037302118,-0.021167396,0.024625495,-0.010832589,-0.059419893,0.0009943148,-0.06226187,-0.029589457,-0.061976947,0.016503148,-0.020843107,0.020737035,0.00085741834,0.014241568,0.07699659,0.019999111,-0.026912943,0.02430618,-0.0540824,-0.115823634,-0.002354641,-0.004990975,0.073375165,-0.080801904,-0.009533142,-0.008469525,-0.011854472,0.01399933,-0.021674335,0.05725587,0.03495758,-0.050621714,0.035040144,-0.011237168,0.039568804,-0.02033995,0.039591417,0.048198935,0.09371463,0.0006794228,-0.00010503883,0.05272386,0.03280575,0.06570036,0.06453705,-0.023508975,0.006190756,-0.056846756,-0.02250152,0.023438921,0.045588832,-0.06639564,-0.0316305,0.014353784,-0.040744886,-0.0149811,0.017252425,0.030230565,-0.035200585,0.02866796,-0.041123476,0.01749628,0.024135038,0.02296853,0.009153518,-0.028067403,0.042440582,0.03083642,-0.003448797,0.08949908,-0.00028240733,-0.058922183,-0.018578885,0.00025287483,-0.030939389,-0.042914893,-0.0016390549,0.038035527,0.04259624,0.057054218,-0.11332501,9.765983e-34,0.033335246,0.018403605,-0.0447311,-0.037850972,0.027575383,-0.016165655,-0.053845134,0.031449445,-0.010885746,-0.039589994,-0.096829996,-0.05237772,0.042000875,0.01837452,-0.036349382,-0.041746087,-0.019225895,-0.057344966,0.011848578,-0.033227842,0.002176229,0.021507794,-0.07038706,0.057107694,-0.0046606525,-0.029559163,0.0042345696,-0.026627136,-0.014139359,0.015120489,-0.00014750368,-0.09857021,-0.04103856,0.016355785,0.06119636,0.077893466,0.017543731,-0.09493734,-0.076199844,0.033888374,-0.08492918,0.07757758,-0.022001088,0.013680619,0.034060705,-0.047964852,-0.05207143,0.08309283,0.026359469,0.0660217,-0.04225713,0.010626145,0.17370467,-0.031071773,-0.048265737,0.013394729,-0.039371807,-0.010124664,0.043533314,0.022289084,-0.02408178,0.000295457,-0.044843778,0.07644118,0.03931521,0.05797503,-0.090221666,-0.12119526,0.07122507,0.045116134,-0.07755854,0.018012227,-0.02286464,-0.009652984,0.07275775,0.009889366,-0.00015722885,0.0077640796,-0.016966961,0.0067874426,0.0319423,-0.014779713,0.07124049,-0.0362131,0.019734217,0.009144753,-0.011086299,-0.038331866,0.040072635,0.006742019,0.09317745,-0.00090292987,-0.10206593,0.06223269,0.052559342,-5.155583e-34,0.034033563,-0.06599068,0.06322027,-0.0078562405,-0.0658647,0.10297797,-0.049133208,0.011582401,-0.021096412,-0.06864052,0.066146985,-0.005353497,0.02782915,-0.005681694,0.013731108,-0.039081514,0.052950554,0.049138993,0.027325705,0.071729824,-0.12027923,0.101582736,-0.03592309,-0.032221768,0.037684247,-0.07177926,-0.004290113,0.022264425,-0.013695885,0.0632271,0.026705896,0.019983497,-0.009620703,-0.0050921883,-0.0024483087,0.07933407,-0.047569547,0.016475791,0.0044633937,0.09701983,0.029938588,-0.00768873,0.0150000835,0.06435801,-0.0034504281,0.044418532,-0.013725957,0.076055124,-0.031406827,-0.10212656,0.035094537,-0.017972756,0.044429634,0.07634576,0.10988838,0.03262544,0.0584954,0.0033167368,-0.03889562,-0.0043799244,0.014382543,-0.028038528,-0.0184736,-0.020560363,0.05894756,0.12384524,0.0049694306,0.07385703,0.047621373,-0.0123231085,0.043314047,0.03086042,0.07040013,0.07423243,0.026629727,-0.047364186,-0.064678915,-0.025751982,-0.051309004,-0.019174851,-0.0037676888,0.04272063,0.010539438,-0.14637113,-0.017683694,-0.022893902,-0.0051765917,0.13109049,0.048856527,0.036849238,-0.042395238,-0.015835196,-0.0839969,0.008987115,0.12967458,-2.7237608e-08,-0.03205502,-0.031051058,0.027080402,-0.04253016,0.00065343897,0.041268963,0.08242728,-0.0039373036,0.023381824,0.055302724,0.0066253333,0.08709932,-0.0043592746,-0.033082876,0.0042393506,0.06410722,-0.0041923034,0.05256067,0.021204395,0.04120424,-0.037487406,0.018387366,-0.04856593,-0.0063713775,-3.1477353e-05,-0.13543165,-0.0067105275,0.02167468,0.015598064,-0.06081584,0.019524453,0.05401271,0.05190545,-0.09722596,-0.17768855,0.023173917,0.00064186665,-0.03234752,0.030653592,-0.031954,0.0354847,-0.0011991828,-0.049482618,-0.03453272,0.0055238577,0.03500171,0.08075231,-0.008434466,0.004930597,-0.0874862,0.0025213277,0.0016520119,0.060898438,-0.039361697,-0.039387874,-0.06645384,-0.022975413,-0.049618877,-0.042027097,-0.0505611,-0.029134655,0.024475642,0.15736167,-0.10665272 +1.3.1.74,"Highly specific for 4-hydroxynon-2-enal and non-2-enal. Alk-2-enals of shorter chain have lower affinities. Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones [cf. EC 1.3.1.102, 2-alkenal reductase (NADP+)].",384,0.99999994,-0.0006789323,-0.04701048,0.008955704,-0.0070721726,0.05604315,0.01094493,-0.0473159,-0.043825746,0.016518792,-0.030596707,0.027787559,-0.0058947583,0.024016093,-0.02525021,-0.05509451,0.14243607,-0.043673232,-0.007544812,-0.022458212,0.030660296,-0.039085228,-0.051310256,0.029984506,0.018210456,0.05985666,0.00066893134,-0.0008060379,0.014028894,-0.08579209,-0.14404471,-0.0052570836,0.020778542,-0.03868618,-0.055308152,0.054998286,0.074541345,-0.08581736,-0.007699275,-0.01640754,-0.030985964,0.0067382464,-0.0052124355,-0.060430728,0.036721364,-0.016157107,-0.03466998,-0.06688895,0.03231118,0.017098159,0.020543858,0.062448792,-0.05726623,0.018489063,0.10319017,0.08050673,-0.030157708,-0.09553429,0.04889434,-0.06425414,0.06523244,0.099665605,-0.032024555,-0.03192822,-0.02369459,0.0059375805,-0.006025569,0.067155674,-0.0850098,-0.07714136,0.0046823574,-0.084314324,-0.09728347,-0.018222764,0.019159717,-0.009602027,0.008664613,-0.023796022,-0.06073214,-0.062414896,-0.0133243045,0.028050568,0.004711376,0.010824432,0.06525955,0.08477324,-0.055447217,-0.04353099,-0.034175992,-0.0507068,0.07745102,-0.0029088273,0.0029349343,0.04507001,0.01238581,0.076142505,0.059836052,0.022206575,0.08319597,-0.087498605,0.016167017,-0.031763233,0.06567963,-0.041406337,-0.08171392,-0.03085969,0.018605722,0.042503595,0.04247204,-0.02817158,-0.055803753,0.029885381,-0.04745823,0.053677157,-0.030434268,-0.016812934,0.10720768,0.01900082,-0.047916975,-0.03657392,-0.039220374,-0.039068088,0.02496217,0.061696216,0.027354138,-0.07254714,0.0066807596,-0.03391274,9.0851565e-35,0.06330029,-0.014932287,0.007888476,0.05828203,0.021818029,-0.024049342,-0.07427887,0.010272771,0.04451795,-0.06355353,-0.041510373,-0.013872025,0.07379531,-0.04486744,-0.0067740134,0.022171339,0.0123541355,-0.013379366,0.03965394,-0.024017196,0.0008450585,-0.003856918,-0.059088252,0.009401524,-0.020519707,-0.006698263,-0.023642847,-0.016255816,0.006406563,-0.01458012,0.027414374,-0.010423112,-0.08787004,0.061599005,-0.005732902,-0.008142852,-0.02904813,0.0198126,-0.0065704715,0.019652126,-0.021667117,0.055241313,0.0041043353,-0.012628712,0.028559146,-0.06925311,-0.017207926,0.07059934,0.047830045,0.045666438,0.092092596,-0.008890928,0.029973993,-0.052457634,-0.036565293,0.019592082,0.023793282,0.01743567,-0.0036836124,0.07056013,-0.0678958,0.017216126,0.017765686,-0.020713013,-0.058282733,0.04641298,-0.15339339,-0.041633487,-0.11505321,0.0012576132,-0.00762119,0.053687125,0.12212221,0.010427986,0.036483847,-0.0041788328,-0.055570155,-0.0069402494,-0.025322475,0.09080215,0.03646884,-0.055674933,-0.035553355,0.015215665,-0.040915795,-0.015896486,0.025147965,-0.048867043,0.07082685,0.06528567,0.030368274,0.060621724,-0.07651634,-0.026520772,0.09821727,-1.6174352e-33,0.15584016,-0.06909632,0.04628177,-0.102888785,0.04367264,0.10181283,0.04316813,0.028918542,0.03549778,0.032284506,0.10160817,0.0878218,-0.0023720968,-0.03760961,0.04358394,-0.05739448,-0.051884614,0.09085521,0.014424332,-0.09089745,0.019102082,0.09151421,0.0041523417,0.067145355,0.04152065,0.04632537,-0.063400395,0.038745094,0.036431275,0.038948227,-0.009755296,0.0045290547,0.001632626,0.06369411,0.035648454,0.09487463,-0.10426972,-0.016838616,-0.0983712,0.07171479,-0.04988513,-0.00041956015,-0.03810691,0.025838384,0.11600908,0.02363581,-0.06882125,0.004788455,0.0046881884,-0.077661745,0.114577584,0.015101228,-0.04983153,0.03297936,0.07780915,0.0769676,-0.096265875,0.03824445,0.09424672,0.012393213,-0.03427651,-0.002504457,0.02285193,-0.007540306,-0.04226642,-0.043251004,-0.023197336,0.06777272,0.008423395,0.03612652,-0.010296773,-0.007014196,-0.045867823,0.036650322,-0.011613528,-0.03425954,-0.030658105,-0.0590285,-0.05331752,-0.041462507,-0.06280788,0.027066357,0.0068523986,-0.016141618,-0.015833642,-0.047230672,-0.0009711875,0.039424848,-0.05648813,-0.019036356,0.016831333,0.008124076,-0.09207099,0.12444132,0.027654305,-4.553501e-08,0.07644354,-0.011521083,0.018760653,0.0079705,-0.01653729,-0.02112095,0.048681006,0.08110668,0.063270286,-0.042335376,0.013504604,0.100491524,0.035568334,0.027356831,0.031173414,-0.043099795,0.009243193,-0.02509839,-0.009373304,-0.0134789115,-0.026635401,-0.0257414,-0.049179498,0.021483904,-0.060869735,-0.045222018,0.020941552,0.020453334,-0.011952569,-0.025955625,0.08301393,0.0041339975,0.02077616,-0.03951224,-0.035407826,0.0458867,-0.07183285,-0.009928843,-0.044619087,0.067244455,-0.10307742,-0.084706455,-0.055875488,0.032849737,0.00788582,-0.065911,0.044307187,-0.023298718,-0.0107544735,-0.03207529,0.045967136,-0.0053756805,-0.024180807,-0.029783107,-0.08371399,0.047371235,-0.01266938,0.011358848,-0.025409833,-0.14358927,0.0055851354,-0.011421802,0.103230946,-0.008594699 +1.3.1.75,"The enzyme, found in higher plants, green algae, and some phototrophic bacteria, is involved in the production of monovinyl versions of (bacterio)chlorophyll pigments from their divinyl precursors. It can also act on 3,8-divinyl chlorophyllide a. cf. EC 1.3.7.13, 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin).",384,0.9999999,-0.115075655,-0.012445766,-0.059933208,-0.031603917,0.06146686,0.051336143,-0.02414344,0.03909246,0.06378898,-0.0013506786,0.03765664,-0.08565831,-0.043002676,0.036181662,-0.021946445,0.06765704,-0.13979103,0.029286845,-0.073266245,-0.030268641,0.005237367,0.016280688,-0.069196224,-0.0034244305,0.01720266,-0.026617883,-0.0022075656,0.020464024,0.0010244278,-0.08016845,-0.024201535,0.044630557,0.07522244,-0.00087830337,0.07002845,0.070901886,-0.02123701,-0.11577871,0.033723343,0.018814005,-0.014161849,0.024491383,-0.023657326,-0.04351909,-0.06568433,-0.020454437,0.013020846,0.065234765,0.023226699,-0.057952218,-0.030242769,-0.031116175,-0.021370295,0.009195183,0.029715946,-0.021273801,0.03691062,-0.049027614,0.017053664,0.01872827,0.02512595,-0.01777739,-0.0083972365,0.020686615,-0.03994377,-0.031673662,-0.016608756,-0.06738196,0.021246275,-0.06855805,-0.034649506,-0.08515148,-0.014075714,0.03018873,-0.006707954,0.030113341,0.04449764,-0.008638127,-0.033514522,-0.03288372,0.06660128,0.029727485,0.0005918312,0.054623205,0.072827704,0.026704673,-0.03759833,0.031502504,0.017573578,-0.010959819,-0.012883118,-0.0021417388,-0.06574556,-0.065004356,-0.097528026,0.106737964,-0.022549737,-0.10230178,0.09532951,-0.029705768,-0.014548804,-0.026134377,-0.0060255392,-0.10933301,-0.023392487,0.004512655,-0.017513892,0.06945311,-0.0095794685,-0.023308918,0.031829543,0.005097706,0.006936917,0.006717693,0.0050405203,0.052118856,0.080843575,-0.07161557,-0.06783884,0.018967347,-0.01873341,-0.0656766,0.010081896,0.04132733,-0.07994396,0.05531445,-0.12751068,1.1515778e-33,0.09379811,-0.016858455,-0.025842363,-0.021725733,0.08150512,-0.026882794,-0.021803634,0.002021992,-0.06611584,-0.115639836,-0.03698143,-0.068066806,0.027961908,-0.015514532,-0.030996032,-0.019434592,0.009090939,0.014681483,-0.05351963,0.0008068047,0.009900731,0.03904091,-0.051838268,0.061385874,0.052232813,0.09745971,-0.0042447816,-0.0156872,0.1409723,-0.053140253,0.059733197,-0.072351165,-0.04470586,0.032400638,0.095947415,0.033229105,-0.05779505,-0.018294645,-0.046863336,0.10520371,-0.005576223,0.060242362,-0.041962795,-0.005724077,0.08961881,-0.0031002036,-0.07403471,0.05073703,0.05126508,0.09143976,-0.0048339944,0.05833776,0.040581524,-0.046481114,-0.044343915,0.05140249,0.013992436,-0.022596011,0.038763497,0.030152036,-0.036910757,0.054127228,-0.05712392,0.020700531,0.025151324,0.058592174,-0.01589594,-0.0017233908,0.033981778,0.07936989,-0.08857148,-0.037812736,-0.023731418,-0.0039905114,0.13037743,-0.02826585,-0.0561123,-0.03762227,0.034129705,0.015347554,-0.00018269225,0.03382711,0.023680307,-0.099410534,-0.1165161,-0.018117603,-0.060150445,-0.010708321,-0.008638774,-0.02003546,0.11052056,-0.05805799,-0.012442702,-0.02681315,-0.036998726,-3.256032e-33,0.05525875,-0.08925781,0.062528044,-0.060616177,-0.0034791061,0.020253336,-0.05451584,-0.06408688,-0.021571241,0.05277992,0.0789544,0.04718515,-0.033691034,0.048282612,-0.008592299,-0.010309832,0.08783162,0.14711374,-0.018465046,0.0004908281,-0.05613065,0.021233562,0.10059042,0.042509872,0.03561755,-0.00735255,-0.016255684,0.04038722,0.040957272,-0.035015773,-0.051816408,-0.02332932,-0.0015062742,0.0054945936,-0.00173983,0.0022315825,-0.07077453,-0.01933277,0.023331609,0.035643045,0.01363271,-0.05068806,0.013924819,0.070381045,-0.036520276,0.01825417,-0.07739335,0.07160477,-0.0082514305,-0.007919493,-0.014647186,0.044221032,0.001724245,-0.0013730655,0.011740949,0.034009937,0.094545454,0.018107599,-0.013734394,0.03904388,0.0125325015,-0.11152553,0.037099004,0.07608184,0.034401458,0.11232724,-0.00983077,0.09060967,0.024709223,-0.02200982,0.045151345,0.044273056,0.05477374,0.02506001,-0.07165448,-0.05536059,-0.013066284,-0.06633465,-0.029180283,-0.0021195572,-0.030291902,-0.010884171,-0.002268835,-0.030737188,-0.021722652,-0.08988241,-0.0026780418,0.0130659565,-0.0016607164,0.003284341,-0.011456501,0.037211612,0.005274579,0.046133056,0.10195704,-4.20125e-08,0.007819273,-0.037153155,0.041017458,-0.06293225,0.046984155,-0.01911321,-0.0007467556,-0.004640553,0.0621405,0.008417468,-0.02426221,0.08405167,0.028752897,-0.031899083,0.069132045,0.016701266,0.018065989,-0.049688417,0.0048875045,0.041073147,-0.048589017,0.001079543,-0.10346504,0.06693383,-0.046181396,-0.03047187,0.0027021456,0.07009517,0.008873157,-0.015072895,0.036667336,0.06275765,-0.069117144,-0.008893953,-0.04840377,-0.03618257,-0.089050524,-0.0513974,-0.11046647,0.030722108,0.035375815,0.0043096547,-0.047715172,0.012546715,-0.017210724,0.038322777,0.0051967665,-0.009208175,0.01372315,0.04675298,0.03409484,-0.025326367,0.03280494,-0.031153116,-0.13704255,-0.016660374,0.026110213,-0.041360345,-0.05727237,0.00488044,-0.012844712,-0.030630942,0.2056566,0.069085844 +1.3.1.76,"This enzyme catalyses the second of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107, uroporphyrin-III C-methyltransferase) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction.",384,0.99999994,-0.102590166,-0.066253364,-0.067856625,-0.006775321,0.05798878,0.033837095,-0.10477068,0.023705827,0.04928155,0.0030818782,-0.059341945,-0.03028421,-0.07268549,0.019943947,-0.0680514,0.031680502,-0.121010214,0.020859819,-0.040866513,-0.039077934,0.1490274,0.020707201,0.042162526,-0.064642,0.01731336,-0.06672798,0.050371666,0.036907542,0.0037561518,-0.061115243,0.05700561,-0.030263262,0.02696239,-0.056294613,0.02027804,0.11011973,0.07933901,-0.019176617,0.04553404,-0.010130875,-0.0075460337,-0.03469536,-0.052927136,-0.0075221793,-0.009723448,0.03018957,-0.015461525,0.040286563,0.0262174,-0.06101374,-0.02174275,-0.009140785,-0.01396535,-0.031025156,-0.009809159,0.01602999,0.00032701791,-0.09598904,0.029201146,-0.00812988,-0.04224135,-0.076011315,-0.02387103,-0.0015875298,0.048858795,-0.036988176,0.0036547128,-0.1296897,0.06990025,0.01729015,-0.05834514,-0.035673518,-0.06233713,-0.013902157,-0.029364917,0.042713694,0.032981277,-0.045657195,0.017417986,-0.043730605,0.043053236,0.023844376,0.07886977,0.066290446,0.063554645,-0.041878205,-0.042205285,-0.004537195,-0.038332734,-0.007427113,0.014430423,0.04025076,0.0128130885,-0.026032323,-0.00083600474,0.055363454,0.015371482,0.031825848,0.026111323,-0.0148543455,0.056521546,0.03602853,-0.07220275,-0.09939426,0.03747759,0.024303323,0.012703546,0.16922344,0.05929731,0.039679464,0.006318194,-0.00033137697,0.04490427,0.02817695,-0.08873801,0.08407804,0.028791893,0.00050267915,-0.03417722,-0.016269056,0.027679006,0.06423598,0.012427145,0.051259395,-0.098368354,-0.0019931353,-0.07534056,5.102241e-33,0.06099108,0.083627395,-0.0665663,-0.0027741187,-0.06691648,0.022235123,-0.032843776,0.01767913,-0.0057230624,-0.070925705,-0.032082867,-0.06263595,-0.026462557,-0.042097345,-0.08148447,-0.049487107,0.020583754,0.030440725,0.034915984,-0.042755604,0.018811902,0.09154807,0.030072538,-0.0073160147,0.03507557,0.06949287,-0.003987387,0.03276778,0.025987245,-0.014090244,0.03025829,-0.051389083,-0.10338414,0.016276358,0.05415972,0.0008903415,-0.008588775,-0.04189186,-0.0056460435,0.050355017,-0.121674724,0.004109166,-0.034240317,-0.085410655,0.04359506,-0.06627599,-0.082019985,0.04151398,0.0117366845,0.04123156,-0.07153998,-0.02741782,0.09528264,0.012121615,-0.025055941,-0.06686364,0.0011365466,-0.027682556,0.01657229,0.07276852,0.03161101,0.09452666,0.008976034,0.13505363,-0.02129691,-0.036678486,-0.0057207416,-0.020858273,0.031872485,0.15103,-0.019746633,0.07996836,0.06694038,0.020846717,0.057791535,-0.051213555,-0.042898316,0.0045552347,0.010731549,0.05290266,0.04093748,0.0054773693,-0.03593563,-0.0018706761,-0.030919416,-0.026969777,-0.026722029,-0.087902576,-0.040254947,-0.0105067855,0.008745619,-0.097351015,-0.030059414,0.026245346,-0.04977617,-6.6222e-33,0.1337922,-0.024069894,0.13013284,-0.08438365,-0.111234024,0.07866714,-0.0023719012,-0.10266127,-0.015400613,-0.01969565,0.05049105,-0.04583706,0.09755609,-0.11386518,-0.018944265,-0.010688291,0.04430097,0.052159112,0.00037494482,0.047304407,-0.0073415847,0.07542635,-0.04179599,0.08458242,0.04449183,-0.038925353,0.031435043,-0.004753365,0.035754107,0.05167129,0.0147333555,0.022103745,-0.06738933,-0.045715205,-0.015427272,0.069324575,-0.037360948,0.045161154,0.059680197,0.035963167,0.044042766,0.023286968,-0.026986541,0.0044279555,0.056115624,0.013958997,-0.12265129,0.039179265,-0.03691392,-0.0678444,-2.2461443e-05,-0.022842772,-0.056176957,0.0008941701,0.026900629,0.005179311,0.049914688,0.008596688,-0.009224929,-0.0023823108,-0.042633463,-0.04522325,0.040675726,-0.039055523,0.01952747,0.10237062,-0.02525614,0.053663235,0.043751583,0.03405825,-0.003100525,-0.04413591,0.07736208,-0.0061641783,0.0006277604,-0.011084756,-0.044585306,-0.05243818,-0.032499034,-0.046740156,-0.0004582564,-0.009464674,0.037564613,-0.03985382,-0.0023617253,-0.09609343,0.07995132,0.08535778,-0.03559468,-0.027717575,-0.01495992,0.06319765,-0.01921051,0.034568995,0.062059227,-4.6969006e-08,0.091444135,-0.03732465,0.01785818,-0.07254812,0.01066275,0.041881125,-0.027335135,-0.017728096,0.0131412605,0.0030469156,-0.029871214,0.083818704,0.041466027,-0.05263901,0.038108487,0.004829855,-0.0542836,0.035705242,0.043258086,-0.011324381,-0.03095142,0.0058615184,-0.08240026,0.0063684895,0.0040553524,-0.069646254,0.038479272,0.012266233,0.012329716,0.026747255,0.0135127185,0.03755463,-0.047752418,0.02892698,-0.02548983,0.058651358,-0.04412139,-0.027608454,0.02084792,0.018846786,-0.026717996,0.024117898,-0.064150915,0.060854856,-0.027849168,-0.016681598,-0.043182816,0.021952871,-0.010750284,0.021674603,0.035099,-0.047450382,0.050943334,-0.06579837,-0.059630625,0.065778166,-0.05011663,-0.118030846,0.0033130106,-0.014123181,0.04558147,-0.034101106,0.07907506,-0.08511544 +1.3.1.77,"The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].",384,1.0,-0.10692476,-0.04237059,-0.14562693,-0.029801074,0.08901304,0.03884495,-0.035458263,0.054097798,0.055309057,-0.020324543,0.034258984,0.0038542196,-0.09366872,-0.07061377,-0.044739537,0.0026420546,-0.049973164,0.042479288,0.0006503666,-0.029693956,0.021733008,-0.02351387,0.020908175,0.021748492,0.039724413,-0.041391816,-0.015190979,-0.023629524,-0.014343082,-0.077871166,-0.0060751047,-0.002436614,0.042491842,-0.04814784,-0.061372314,0.10197229,-0.07463907,-0.049830493,-0.009068208,0.0061718714,0.05615983,-0.011445495,-0.028930672,-0.068329535,-0.008831237,-0.03576613,-0.054740477,0.06467601,0.029423656,0.025912814,-0.045637377,0.03931558,-0.032121666,0.007732296,0.0639898,-0.005270636,-0.019156596,0.008740735,0.01729694,0.034127466,-0.010449331,-0.03598663,-0.01932975,-0.041425806,-0.012675111,-0.044207588,-0.0337572,-0.018931014,0.043518364,-0.030898722,-0.022534503,0.010019524,-0.01752522,-0.016077472,-0.048501033,0.16371466,-0.015613245,0.046577126,-0.07630295,0.0024888816,0.03200031,0.060925007,-0.026504062,0.070444345,0.04440585,-0.022209276,-0.063305266,0.03604137,0.0069003776,0.094959565,0.110013045,0.051756646,-0.00310338,0.043306,-0.10051834,0.05206467,0.049070835,-0.0028081746,-0.022178737,-0.015867135,-0.0018871203,0.0071107084,0.061312474,-0.1212076,-0.0836499,0.009322425,-0.03765923,0.022596601,0.054290447,0.03604155,0.024470136,-0.018739624,-0.018998725,-0.012578163,-0.043561146,0.072632395,-0.085183606,-0.028225172,-0.0051868614,0.014822121,-0.07473646,-0.005662901,-0.0050044847,-0.008221592,0.05233423,-0.040527884,-0.122502215,5.3024842e-33,0.07158714,0.027394727,-0.05939493,-0.033649016,0.09207929,-0.008159121,-0.028042948,0.08744204,0.01770909,-0.06695766,-0.07085736,-0.04495095,0.01417232,-0.04257347,-0.018523587,-0.05168505,-0.032652363,-0.0991465,0.04103252,-0.009449915,0.023667397,-0.005528579,-0.13286826,0.014772108,-0.072586894,-0.024994994,-0.009461373,0.019286806,-0.042273276,0.01424824,0.019858913,-0.110959925,-0.027342802,0.042387843,0.088241085,-0.053974397,-0.06870097,-0.07909968,-0.07689737,0.067185596,-0.05591042,0.006408437,-0.008950497,0.06083339,0.103916295,-0.04521342,-0.01863871,0.09151052,0.03825136,0.090301916,0.057333797,-0.022081222,0.1551873,0.018697202,-0.04449605,0.038047917,-0.07846569,-0.0025891636,0.031164056,0.070089854,0.0077016843,0.058293633,0.042064242,0.034670547,-0.060528405,0.0737167,-0.117493026,-0.11841488,0.060025837,0.0084028,0.059574213,-0.03384088,0.042188328,0.0525451,0.095602885,-0.013769894,-0.040294502,0.029827457,0.04418003,0.010031744,-0.008627741,0.03187518,-0.025396852,0.08134134,-0.06864818,0.035147898,0.014486569,-0.019224973,0.032020144,0.0440286,0.10826987,-0.05180613,-0.033030882,-0.025726482,0.038756367,-4.3402925e-33,0.10351357,-0.03100661,0.07928086,-0.063741036,-0.080020525,0.032398995,0.06072693,-0.08378013,0.002763447,-0.07680814,0.061230157,-0.016377745,0.023965603,-0.0067485673,0.006349767,0.033926833,0.029149072,0.07819258,-0.06816953,0.0073019457,-0.040901963,0.07073997,-0.027487732,0.040825747,0.028982295,-0.052058414,0.015015253,0.044950053,-0.01447048,0.051565554,-0.021864178,0.022888374,-0.085228875,-0.043764677,-0.007041187,0.037408542,-0.052982695,-0.001161832,0.01625569,0.07303984,-0.0024237586,-0.014280269,-0.0195139,0.045374725,0.057328656,0.0039813276,-0.08204967,0.04456571,0.011252659,-0.016129738,0.024987435,0.051716562,0.017255992,0.048228014,0.049209747,0.00023401687,0.033901386,-0.00022677076,-0.0061597005,0.014469166,0.03524268,-0.10926136,0.027265975,0.043095607,0.07727202,0.045803603,0.07453458,0.04473759,0.048804156,0.0003549091,0.07721866,-0.006748929,0.095960945,0.060056865,-0.018576518,-0.0015538642,-0.0084117,-0.013788527,-0.096665815,-0.03977439,0.00816631,-0.04977755,-0.023211826,-0.09970236,-0.07745383,-0.014230708,0.05077959,0.020680407,-0.07032468,0.031440765,0.01712535,-0.001184586,-0.024993032,0.06704239,0.071089,-4.26517e-08,-0.0006971594,-0.0558693,0.009196681,-0.0014090675,0.04501719,0.009605665,0.020094458,0.028452516,-0.03597227,-0.011649559,-0.030079613,0.08012511,0.0010618791,0.027762605,0.1294482,0.007843046,0.067693345,0.039373692,-0.027635561,0.025645088,-0.050256085,0.003919092,-0.1320182,-0.008755522,0.013051183,-0.027786637,0.023759771,0.012230327,0.0847796,-0.019196376,0.06161567,-0.012270149,0.041373864,-0.027288968,-0.037512403,0.051684514,-0.05510572,-0.034481216,-0.015662346,-0.02250138,-0.04873186,0.003127651,-0.01340964,0.018259173,-0.028374404,-0.047532164,0.0053329295,0.07014257,-0.052654993,0.0020587642,0.042299144,-0.00017821048,0.039869845,-0.06280956,0.007942788,-0.032548264,0.034504335,-0.0102072675,-0.0699495,0.026105758,-0.043102235,0.032151796,0.09027468,-0.044522755 +1.3.1.78,"Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].",384,0.99999994,-0.11478178,-0.04135288,-0.07648487,-0.06379727,0.011250542,0.0513206,-0.09988437,0.008697002,0.00830922,0.02513722,0.0591307,0.024394583,-0.12671235,-0.016407717,-0.009822103,0.04194875,-0.017115466,0.012630644,0.062016238,-0.029194973,0.06891434,0.019369844,-0.05872046,-0.033038374,0.123825595,-0.043195978,-0.06255449,0.042984907,-0.021546762,-0.038169246,-0.0920457,0.037322868,0.014936964,-0.041028738,0.0030551606,0.0914883,-0.083875075,-0.08139714,0.03816775,0.01948225,0.0729747,0.002480577,-0.11300931,0.027345655,-0.06731743,-0.041914638,0.025437534,0.073241055,-0.025872633,-0.06719312,-0.03408807,0.033349942,0.06384116,-0.03915912,-0.02755171,-0.02772076,0.014900355,0.034481816,-0.0077949213,-0.037123512,0.0048009115,-0.062222555,-0.017333558,-0.020743504,0.02815891,-0.042830627,0.035740327,-0.024347562,0.02302357,-0.011134673,-0.096098974,-0.008108967,-0.023626039,0.037113354,-0.0651867,0.12603077,-0.03500165,-0.014388638,0.012075525,-0.04988589,0.022873772,0.04690229,-0.027781041,0.024714744,0.096545875,0.014176491,-0.044704355,0.03463044,-0.025724595,0.06386516,0.05941795,0.036930516,0.037400395,0.009293488,-0.11983179,0.10088323,0.05380875,0.0025231463,-0.0064845006,-0.048766907,0.03697073,0.10649464,-0.040366787,0.004625781,0.00664872,0.034407835,-0.034501035,0.026468284,-0.044857975,0.011739674,-0.020201711,-0.03483701,0.00784193,-0.029643944,-0.049836595,0.055085517,3.3361168e-05,-0.05956849,0.009183621,-0.05777036,0.0023551213,-0.059841864,0.038446747,0.03011196,-0.011529905,0.017158976,-0.12692796,3.7154067e-33,0.11405084,0.013334009,-0.03734696,-0.008217672,-0.0043939273,-0.0070265797,-0.07637438,0.08144847,-0.04659906,-0.04138579,-0.10305272,-0.08599463,0.039275233,-0.024312967,-0.028191421,0.046006735,-0.034852155,0.022874704,0.0061639696,0.06543984,0.001400874,-0.0028490596,-0.06087342,0.002445403,-0.005529729,0.02473712,-0.039896693,-0.0026226616,-0.008607643,-0.01659409,0.05799583,-0.109556496,-0.07558109,0.008073575,0.05685923,-0.03588443,-0.036615524,-0.033032794,-0.03424283,0.04305698,-0.05746782,0.115997896,0.09590794,-0.058825776,0.061669145,-0.022708979,-0.009411636,0.09005809,0.034421254,0.08062645,0.04295559,0.008934146,0.08219048,-0.064701304,0.0019796717,0.04145666,0.011378408,0.043419335,0.022503622,0.092976645,-0.014857845,0.01172607,-0.022653677,0.0757593,-0.05502933,0.05358584,-0.11707745,-0.061153762,0.047204606,0.07849307,-0.018631231,-0.022218294,0.033016868,0.066461965,0.054816615,-0.024622273,-0.0022059544,-0.008580776,0.027987331,0.00091149495,-0.014577947,-0.033266395,-0.035393808,0.0023579644,-0.03802095,0.009513988,-0.02756133,-0.00031053482,0.04180354,0.05552315,0.08339712,-0.0029874959,-0.02499871,-0.055259578,0.039114665,-4.119657e-33,0.103700876,0.023501199,0.007638468,-0.12164152,-0.07599306,0.14007567,0.041955233,-0.11578564,-0.00032063,-0.028979504,0.07908403,0.041444212,0.043883007,-0.04445827,0.009824697,-0.052588545,-0.0282134,0.054488555,-0.02613367,0.0038987442,-0.025796829,0.06699454,0.065323986,-0.0006704406,0.038314212,-0.10532422,-0.07013779,0.08871607,-0.004491141,0.0016810802,-0.038495243,0.04646363,-0.031763565,0.016649812,0.0048734643,0.009287259,-0.0719401,-0.016586564,0.014508332,0.03652262,0.049802065,0.00025996641,-0.08428549,0.064596236,0.013518005,0.017758856,-0.1322802,-0.005704559,0.003506914,0.002295639,0.02514823,0.021105526,-0.012636881,0.012165496,0.055585615,0.0007887212,0.02961726,0.034625854,0.009323376,0.031515803,0.02249576,-0.038480714,0.051095817,-0.00056504714,0.033483967,0.020949092,-0.0048616845,0.11721791,-0.020581776,0.013068871,0.041814554,0.018626528,0.02467647,0.01148267,-0.011974541,-0.06532891,-0.02611347,-0.017706422,-0.04755648,-0.066132754,-0.015922219,0.07068363,-0.05192769,-0.02743199,0.0077827317,0.028774545,0.04000645,0.06213294,-0.045580357,0.055607524,0.0015514547,0.052813005,-0.024408694,0.063711144,0.017915275,-4.6926672e-08,0.026502432,0.025532436,0.08359245,-0.0639084,-0.018545246,0.011152579,0.021574829,0.0036204236,0.044310857,-0.0056086564,0.008130692,0.11103234,0.048328485,-0.012434444,0.05964107,-0.017263532,-0.027850969,0.013227784,-0.04674759,0.028607087,-0.043899424,0.033856813,-0.19040288,0.030437892,0.06421509,-0.042754315,-0.005125206,0.024292527,0.09114133,-0.036658473,0.05832497,-0.0032020453,0.06267751,-0.032758903,-0.01030988,0.021122187,-0.06100614,-0.012658895,-0.051034484,0.006793114,-0.058119286,-0.07289791,-0.07427117,-0.01442597,0.0060462495,0.010048488,0.007740595,0.009871963,-0.031387366,0.034051612,0.04895461,-0.003287061,0.06332295,-0.11822333,-0.03079419,-0.0011403833,0.016676426,-0.03757634,-0.057782866,-0.024655247,0.046312958,-0.032184735,0.13124196,-0.02332182 +1.3.1.79,"Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans.",384,1.0,-0.037042487,-0.06349328,-0.15251303,-0.1039556,0.029937292,0.07675123,-0.10362693,0.006551309,-0.013485964,-0.03418023,0.048987165,-0.06787423,-0.10374905,0.021480152,0.00038627625,0.0064923093,-0.020669175,-0.028480008,0.05513526,0.012552423,0.05878304,0.047484674,-0.036488958,0.014182383,0.0053665023,0.037564985,0.036255866,0.048085097,-0.009545983,-0.0756205,-0.07054735,-0.014720386,0.055771075,-0.0648612,0.05715082,0.063444525,-0.07960386,-0.06935281,0.082787484,0.08456076,0.08000403,0.04045524,-0.05717691,-0.03111913,-0.041184206,-0.058052115,0.026529096,0.09693454,0.046176586,-0.03582027,-0.045127045,0.014433618,0.027291048,0.00049133017,-0.029115142,-0.02635644,0.074056976,-0.025871683,-0.06363279,-0.044495318,0.00389695,-0.0706435,0.042723343,-0.007818952,0.0017268062,-0.042205002,0.03151519,-0.044852715,-0.008227021,-0.051688664,-0.13860191,-0.0017316105,0.0144165,0.06453396,-0.018788034,0.07716037,-0.05928031,-0.09198104,0.04671812,-0.06427724,0.03973038,0.011385725,-0.025458867,-0.0037795687,0.060248584,-0.030754056,0.0033589574,0.031891685,-0.011435091,0.013486533,0.07883038,-0.040051937,0.056425024,0.017681971,-0.10250472,0.034345273,0.015381767,0.041865423,0.034043044,-0.09845236,-0.03538096,0.056023274,0.0018940058,-0.0062113954,-0.023590682,0.01783843,0.010146729,0.111967154,0.017564664,0.029835392,-0.015845427,-0.049349036,0.0072382214,-0.04738071,-0.013397035,0.088783056,0.057139162,-0.097137675,-0.0031997415,-0.051416222,0.048884366,-0.1064622,0.05209091,-0.011890254,-0.010014456,0.03580322,-0.12656507,4.091587e-33,0.092125386,0.017174486,-0.009047294,-0.020692633,0.015436898,0.04519003,-0.12614343,0.03518537,0.004725065,-0.062155675,-0.031932995,0.043406002,0.056937683,-0.04278347,-0.011016872,0.02600313,-0.027870584,0.035237342,-0.023176733,0.08078115,0.0652205,0.07900892,-0.05354794,0.010546955,0.040847786,0.04255177,0.025529893,0.021626737,-0.026861103,-0.004342722,0.0618171,-0.11323696,-0.112755,0.012388445,0.0763193,-0.027204515,-0.027781218,-0.035486534,-0.0066931825,0.00561945,-0.029921725,0.07395488,0.017381676,-0.0771605,0.030641697,-0.13970077,-0.03048885,0.10551758,0.011379238,0.09645442,0.032780185,-0.015772574,0.073451154,-0.051126923,-0.011016914,-0.00271577,-0.0137636475,0.043830447,0.07009295,0.06647281,-0.011516446,0.04490441,-0.026407152,0.04471904,-0.028784577,-0.011067553,-0.067232884,-0.019845385,0.068822294,0.05541769,-0.035449874,0.027315203,0.01541597,0.02829319,-0.03782895,-0.05709528,-0.008882918,0.0067897826,0.0028693415,0.02249561,-0.02643918,0.039599914,0.032197412,0.0064460775,-0.055641856,0.10551081,-0.04145593,0.021953644,0.024652118,0.01685358,0.08059263,0.022684714,-0.0022062282,-0.0108137205,0.028200895,-4.1208795e-33,0.095791094,-0.045163006,-0.0034799834,-0.12997714,-0.042621102,0.13347973,0.047791377,-0.061682828,0.01186521,-0.049721256,0.06504227,0.0633773,0.07068738,-0.03344393,0.087254375,-0.040907588,-0.034424312,0.016754474,-0.048121795,-0.06414115,0.03362541,0.04466501,0.0743502,-0.031624664,0.037922766,-0.037148423,-0.06333421,0.02935518,-0.014035888,0.022921318,-0.024955224,0.036216557,-0.029111534,0.009236985,-0.021149836,-0.03735682,-0.07097982,0.042138454,0.02244414,-0.019544173,0.0021169807,0.025352763,-0.039242513,0.045078978,-0.0044206753,0.056318484,-0.061220083,-0.031597584,0.09696454,-0.0052269865,-0.021799516,-0.012311319,-0.09059671,-0.025786772,0.0029773058,-0.006866077,0.015399097,0.031263594,0.021590779,0.020110756,-0.030514421,0.001984451,0.004245188,-0.00030225702,0.032070328,0.027451148,-0.0008128811,0.015118429,0.07714282,-0.025654769,0.053472552,0.068143055,-0.01772361,0.040008783,-0.02179327,0.005321361,-0.0727092,-0.0019856098,-0.0062767244,0.030186502,0.033973355,-0.04165708,-0.029761313,-0.0065854145,-0.024420677,-0.04720705,0.01227402,0.008674947,-0.09003077,0.03398031,-0.049058747,-0.0036442094,-0.0072707837,0.028265627,-0.016000085,-4.2564423e-08,0.04618782,0.016466418,0.08739777,-0.015514174,0.0069289766,0.018324392,-0.06238194,-0.04020304,0.08988958,-0.022606932,0.03275635,0.052660447,0.029071633,0.03544985,0.052169457,-0.013607621,-0.016945021,-0.023513181,-0.018273337,0.027931249,-0.054336876,-0.03336489,-0.09648406,0.08756793,0.0039926707,-0.006282144,0.017209902,0.0037397936,0.08075097,-0.027999252,-0.016326154,0.025555503,0.07983327,-0.04838011,-0.015833609,0.015351087,-0.06490507,0.060043328,-0.08341207,0.068810806,0.057965774,-0.12813978,-0.08690853,-0.024088303,0.025443302,0.043479398,0.019170891,-0.033334684,-0.041645184,-0.06850628,0.02986123,-0.053897813,0.076909825,0.0067392588,-0.06958371,0.029049056,0.0056485515,-0.09801839,0.003832615,0.0026347188,0.07147538,0.007858701,0.14804538,0.0037288968 +1.3.2.3,"This enzyme catalyses the final step in the biosynthesis of L-ascorbic acid in higher plants and in nearly all higher animals with the exception of primates and some birds [5]. The enzyme is very specific for its substrate L-galactono-1,4-lactone as D-galactono-gamma-lactone, D-gulono-gamma-lactone, L-gulono-gamma-lactone, D-erythronic-gamma-lactone, D-xylonic-gamma-lactone, L-mannono-gamma-lactone, D-galactonate, D-glucuronate and D-gluconate are not substrates [5]. FAD, NAD+, NADP+ and O2 (cf. EC 1.3.3.12, L-galactonolactone oxidase) cannot act as electron acceptor [5].",384,1.0,-0.064851396,-0.07642997,-0.038315877,-0.017971748,0.12263889,0.074755825,-0.10908203,0.033892687,0.016971292,0.028117914,0.036395192,0.000956422,-0.106364965,0.03214858,-0.057603333,0.04113901,-0.050225947,0.009571958,-0.02874158,0.036453497,0.0865374,0.020535395,0.025060395,-0.03375992,0.13638198,-0.059063498,-0.037213527,-0.044124003,-0.021094061,-0.08891461,0.002467861,-0.053430837,0.05122611,0.024201173,-0.038753476,0.044551183,-0.0049096984,-0.06923264,0.10359965,0.025185699,-0.008060804,-0.06265085,0.0069424934,-0.06339614,-0.04398561,-0.03229626,0.01720421,0.0008934011,-9.714919e-05,-0.027236003,-0.020398071,-0.01086832,-0.027535157,0.002343746,-0.095016524,0.04932491,0.010201604,-0.027593747,-0.025611805,0.00050359813,0.012907015,-0.00030869685,-0.022440672,0.03813101,-0.019351719,-0.043366097,-0.032507107,-0.059804793,0.03278205,-0.008916547,0.005146467,-0.09152866,-0.0074533103,-0.01060317,0.037250407,0.10736009,-0.010616827,-0.00994439,0.07544259,-0.06740629,0.017067302,0.0014156431,-0.009776382,0.045159757,0.034332972,-0.04795605,-0.05096063,0.110419706,0.024494287,-0.005021368,0.022534136,-0.02867129,-0.04417283,0.04498718,-0.04512716,0.05796588,0.1447709,-0.030362649,0.012782121,-0.029222839,0.0072115245,0.074169606,-0.015090995,-0.049997017,-0.0038667014,0.031887192,-0.02902343,0.060473625,-0.017727256,-0.094587825,-0.01855984,-0.030518813,0.0048808614,0.029210424,-0.021578733,0.06398782,0.024827376,-0.104512036,-0.091068216,-0.032005206,0.0035772931,0.007055727,0.043447275,0.06515746,0.020046035,0.034591008,-0.046258256,1.6883442e-33,0.072960444,0.067756414,-0.05931764,-0.10356413,0.026858391,0.024086524,-0.104298756,0.033025775,-0.046944443,0.017784692,-0.086443365,-0.065992,0.0511376,0.008800688,0.024135584,0.052009292,0.01946805,-0.056919888,0.04197214,-0.013933794,0.017529903,0.02478154,-0.047546074,0.053639613,0.039014578,0.019590763,0.02027787,0.057772327,0.01766086,-0.010177338,0.03005676,-0.13202962,-0.049617745,0.050246138,0.032436844,0.027659355,-0.10392382,-0.07589416,0.043253623,-0.014797089,0.005534056,0.06199278,-0.066877715,0.01688221,0.0019060301,-0.0004579373,-0.011202817,0.037951767,0.038883857,0.089851476,0.062412966,-0.031920448,0.060298484,0.019610472,-0.028268125,0.047349032,-0.1078674,0.056963272,0.02982626,0.035528027,0.053087544,-0.010647905,-0.013402309,0.08445314,-0.020129984,0.0087167565,-0.04730992,-0.015905619,-0.014052446,0.05681714,-0.036521707,-0.097276844,0.05576613,-0.015988722,0.03642306,0.010086346,-0.024721393,-0.0026192968,0.0349867,-0.004879053,0.002404151,0.03874034,-0.04445458,-0.0077010933,-0.02662149,0.048420653,0.027001306,-0.041455228,0.042999305,0.025650175,0.0031433597,-0.057259567,0.01895088,-0.039140508,0.028377952,-3.1648242e-33,0.07178091,-0.07898582,0.08014304,-0.09441114,-0.054477397,0.05949159,0.034691647,-0.087264605,0.03397411,-0.05953329,0.03430147,0.03700275,0.036302716,-0.06365291,0.0155412285,-0.012464382,-0.030463569,0.11969432,0.024616536,0.028521199,0.025813576,0.10042817,-0.0056510703,0.03469427,0.09416303,-0.023904061,-0.061197896,-0.0022250612,0.043250594,0.022596192,0.035144113,0.06299895,-0.017117443,-0.06666207,0.029323392,0.048750207,-0.082868636,0.023151461,-0.008639391,0.05029625,-0.009661613,0.009077168,0.017609252,-0.0027958597,0.113825455,0.07149497,-0.11309395,-0.025036173,-0.021869695,-0.038030732,0.0006026737,-0.0009769397,-0.0074245967,-0.0061496724,0.09105972,0.06984361,0.025007073,0.009388759,0.008208501,-0.045935113,-0.04159328,-0.07716627,0.032330416,-0.061064288,0.05941364,0.011816452,-0.029130157,0.08466634,5.409011e-05,0.0087721255,0.10377459,0.046727736,-0.016796498,0.08197959,-0.009873247,0.03701202,-0.08480168,-0.047616057,-0.06340727,-0.04605855,0.011187274,0.04062664,0.015038186,0.0027475005,-0.039091967,-0.07141975,0.018173384,0.15067309,0.0014329471,-0.00051616284,-0.055090934,-0.037907775,0.013247073,0.033617176,0.112496085,-4.844956e-08,0.013952857,0.0070960075,0.060045995,-0.09810692,-0.009305094,0.0020011752,0.018065836,-0.055538207,0.043781597,-0.052094232,-0.015835978,0.10960797,0.004582027,-0.015843492,-0.014282797,-0.029806335,-0.030498698,0.056774657,-0.016920352,0.06034788,-0.05926909,0.026990516,-0.12800722,-0.016337233,0.019254878,-0.08944666,0.022609273,0.040691197,0.01810436,-0.05427202,0.04037457,0.040736042,0.11398183,-0.055718604,-0.02603823,0.022965068,-0.020041399,-0.05798813,0.021099346,0.025618376,-0.012401386,-0.0819219,0.022921039,0.006682817,-0.037413113,0.004130746,-0.0077100815,-0.0033181757,-0.024155257,0.031169463,0.007946198,-0.05297476,-0.042923424,-0.11970363,-0.05864387,0.028912237,-0.032393456,-0.05614293,-0.015223397,-0.10587446,-0.0035116225,-0.010303807,0.12079479,-0.074956514 +1.3.3.1,"A flavoprotein (FAD, FMN). Ferricyanide can act as acceptor.",384,1.0,-0.008866717,-0.08248841,-0.1340518,0.10596174,0.07019215,0.006794433,0.08100478,0.04961561,0.02500543,-0.071251325,0.0075647193,0.012240538,-0.088609405,0.028930368,-0.10758871,-0.008001609,-0.053738303,-0.006226082,-0.044529457,0.06464699,-0.08783685,0.004023619,0.06255126,-0.06816361,-0.070343964,-0.020044535,0.0022827126,-0.02503024,-0.0041488167,-0.04899697,0.062305886,0.084253006,0.0912236,0.053131018,-0.06420504,0.012888814,-0.014704927,-0.009781324,0.0032822313,0.015390077,-0.010122936,-0.054543223,0.05636006,-0.044763085,0.039265238,-0.02594482,-0.04297988,0.04481138,0.01614134,0.05394015,-0.050382018,-0.043922503,-0.08582973,0.09476336,0.01889651,0.027072284,-0.023369607,-0.070636086,-0.025751377,0.04904812,-0.035691455,-0.043659355,0.0238692,0.0066415584,0.04194961,-0.04321756,-0.029225575,-0.059642117,0.018875092,-0.013731053,0.06337322,0.016854694,-0.044143483,0.009146703,0.015293869,0.12948732,-0.0354572,-0.013936863,0.07753764,0.012657959,0.030653967,0.017798157,0.06886074,0.036355834,0.060761724,-0.037391223,-0.048165426,-0.009063225,-0.086391486,0.14299893,0.0072867596,0.0670864,0.022747155,-0.023190707,-0.046874516,0.0076316157,0.077225685,-0.032164816,-0.08535993,0.016488642,-0.09329105,-0.04991325,0.02588256,0.014335127,-0.11348233,-0.04264211,-0.004268126,-0.033219837,-0.04307596,-0.0656534,-0.027380317,-0.036216535,0.027448874,-0.10232841,0.012011956,0.0038001942,-0.002344181,-0.028791105,0.028260665,-0.01339987,-0.07213347,0.101006754,0.021000922,0.026238233,0.016100856,-0.024175327,-0.10108213,1.600857e-33,0.05232861,0.049271155,-0.05157495,-0.007046847,-0.006419931,0.01651392,-0.04080532,-0.028102186,0.06188466,-0.038915887,-0.065115504,0.034202844,0.013092383,-0.06486186,0.012429935,0.015333771,-0.023396816,-0.053586658,0.05632552,-0.092213646,0.08464877,0.04420743,-0.0053814,-0.019065667,-0.007104235,-0.015904162,-0.08337546,0.037104625,0.010321821,0.03795314,-0.0034342597,-0.05980833,-0.017916335,0.0031130058,0.01705417,0.016560458,-0.023767972,-0.074771896,-0.10125043,0.03298787,0.0012148612,-0.02753166,-0.089758046,0.044434763,0.04694579,-0.0017580828,-0.07714271,0.0575632,-0.0044835075,0.09879871,0.031606004,-0.07569643,0.046954926,0.0310122,-0.07862615,-0.008761658,-0.022267934,0.021588668,-0.0035894576,0.010411223,0.018668257,0.05201316,0.013929099,0.014803793,-0.049678523,-0.03622808,-0.038273767,-0.037853368,0.017970724,0.03304493,0.059324704,-0.022728112,0.10901143,0.017155612,0.07686346,-0.037206493,-0.07962909,-0.040104505,0.027316548,0.0175525,-0.023055334,-0.031221533,-0.022378342,0.023854895,-0.031483326,0.060369235,-0.02142249,-0.031444535,0.016511356,-0.021158002,0.0637634,-0.039280944,0.017900318,-0.010249515,0.06909293,-1.3788166e-33,0.030016378,-0.11174622,-0.009017048,0.073472105,0.0021291566,0.042090513,0.0045154225,-0.044748418,0.03229265,-0.03043102,0.051607054,-0.079070896,0.014187027,-0.0456342,-0.0055904994,0.01820592,-0.025091626,0.0864928,0.036448713,0.03529169,-0.097544774,-0.026398718,-0.013272986,0.0939138,0.05956437,0.03788471,0.033784885,-0.061138015,-0.010392114,0.07481681,-0.034807034,0.052987177,-0.062512554,-0.07529286,0.012042816,-0.010786671,0.004395551,-0.038515262,-0.011074433,-0.0068486077,-0.045924816,0.02134147,0.041660886,0.10380243,0.056319322,0.06471167,0.018324986,0.057926036,0.06740437,-0.004682841,-0.018020814,0.03782771,-0.03415684,0.0624499,0.03820801,0.03569341,0.11563079,0.0013245903,-0.030212764,0.047425933,0.0009752946,-0.13201922,0.03624872,0.014846556,0.09242518,0.08268274,0.02579334,0.13260734,0.06923998,0.0035782184,0.0807707,-0.034765724,0.061022736,0.06251908,0.04388659,0.00391163,0.02350832,0.07251293,0.0014698023,0.042053893,-0.019349083,-0.017057916,-0.03587737,-0.0028379473,-0.022108017,-0.11896699,0.015384649,-0.022926107,-0.02269606,0.018146485,-0.009520767,0.079576544,-0.020776484,-0.059663344,0.050160885,-2.4192286e-08,0.0068720444,-0.082263894,-0.039232817,-0.045311227,0.12236732,0.0055434695,-0.07248431,-0.04238572,-0.030770924,-0.03026764,-0.038037613,0.14438002,-0.008914411,-0.005435616,0.075901195,-0.06536922,0.04223793,0.030277468,-0.02669632,-0.0068391347,-0.08996909,0.033202123,-0.059323553,-0.019661818,-0.054977875,-0.025298042,-0.015630106,-0.01764796,0.0714226,0.002111147,0.041417774,0.017305456,-0.0064115915,-0.05300397,-0.08590031,0.055456225,0.07297979,-0.093176894,-0.05239577,0.03886885,-0.019154625,0.007297478,-0.016695475,-0.03640626,-0.05808015,-0.016308418,0.018736608,0.004030901,-0.05757444,-0.052211095,0.018951133,0.0048175976,0.015063563,0.020566845,-0.0360105,0.0038772384,0.041518476,-0.012517189,-0.014395636,-0.060517263,-0.040786352,0.041083977,0.1246122,0.019876776 +1.3.3.4,This is the last common enzyme in the biosynthesis of chlorophylls and heme [8]. Two isoenzymes exist in plants: one in plastids and the other in mitochondria. This is the target enzyme of phthalimide-type and diphenylether-type herbicides [8]. The enzyme from oxygen-dependent species contains FAD [9]. Also slowly oxidizes mesoporphyrinogen IX.,384,1.0,-0.068797804,0.027034992,-0.08199924,-0.0399426,0.13923453,0.029122058,-0.023490846,0.055612464,0.04510562,-0.010802531,0.044607636,-0.034845125,-0.08799344,0.021228319,-0.03847406,0.09076361,-0.15387712,0.026507746,-0.08867695,-0.059498552,0.03780401,0.090492465,-0.06064185,-0.011985685,0.02977536,-0.057312995,0.026033144,-0.045443952,0.022018686,-0.070920505,-0.006156665,0.012055796,0.03418063,-0.014319734,0.040687617,0.07639387,-0.004303519,-0.10699103,0.032268,0.025987526,-0.023002397,-0.010685814,-0.069363706,-0.049389094,-0.10469797,-0.011209137,0.006966247,0.015077045,-0.018547306,0.017840238,0.03404618,-0.03973695,-0.055227477,0.011572343,0.0501018,-0.042054683,0.02405414,0.029671831,-0.009936154,0.012728921,-0.013425755,0.014872724,-0.02233293,0.008540646,-0.026441433,-0.008199163,-0.01211546,-0.043698,0.051013857,-0.11084201,-0.026771747,-0.11953345,-0.0851443,-0.005913735,-0.016919408,0.024765663,-0.026322521,-0.025991501,0.012625675,-0.06728316,-0.00221741,-0.02425546,0.064961575,0.023013603,0.071795784,-0.009854049,-0.05632096,0.031424932,0.056195576,-0.009270171,0.004478114,0.03280616,-0.040783834,-0.01198236,-0.072789244,0.13012736,0.06918375,-0.027953876,-0.034478806,-0.00030381363,0.017599178,0.019288328,-0.043196674,-0.053074572,-0.031944983,-0.0280692,0.009459047,0.02342707,-0.018941097,-0.0572939,-0.025524372,0.016312681,0.03418519,-0.020346371,-0.02020214,0.024297357,0.015173015,-0.05720152,0.013112545,-0.0010222648,-0.045225758,0.022954034,0.01601798,0.06417232,0.025974326,0.051338248,-0.10365736,3.460451e-33,0.074365415,0.039688703,-0.021861926,-0.03877174,-0.077756695,-0.04387544,-0.077463046,0.027898557,-0.012217745,-0.06950761,-0.053724196,-0.11442941,-0.038298357,-0.078259274,0.029729832,-0.043502122,-0.02271358,0.008335416,0.030419985,-0.016403474,0.008380139,0.08090986,-0.103220046,0.0050934833,0.02094633,0.031678263,0.0013501693,0.012936515,0.08859423,-0.006748799,0.04107548,-0.05679117,-0.055161737,0.026918802,-0.008594272,0.0339203,-0.09092055,-0.0004787425,-0.06326712,0.0709418,0.026680622,0.057524834,0.012767777,-0.05326741,0.10558136,-0.039309558,-0.07950396,0.048437666,0.056450907,0.07789643,-0.06415274,0.02059465,0.11988749,0.041259527,-0.06533221,0.024163347,-0.018550202,-0.042619426,0.03452671,0.044351783,0.010073081,0.06512206,-0.054473788,0.055130698,0.049192466,-0.008855715,-0.032854103,-0.012139782,0.007339792,0.11980258,-0.03870695,-0.07777223,0.021536816,0.011527625,0.114460446,-0.08961394,0.043764815,0.0059232726,-0.003354114,0.0012652114,0.068204105,0.047777895,0.024006246,-0.08121797,-0.047882274,-0.02211328,-0.0520403,-0.051890053,-0.021626806,0.07235534,0.076774664,-0.08165417,-0.023453059,0.0026363328,-0.016548105,-3.7372782e-33,0.054334603,-0.058755267,0.09150174,-0.08351093,-0.026564255,0.04886337,-0.017115567,-0.023151238,-0.01281261,0.011783887,0.066055536,0.02099559,0.010732322,0.011658748,0.011595699,0.045870412,0.028134743,0.070555486,0.049570274,0.03827814,-0.07106185,0.03540753,0.037194777,0.025939913,0.04745377,-0.0026201413,-0.013957645,0.01363478,0.0607198,-0.02222523,-0.015931267,0.03235779,-0.026435094,0.04613361,-0.020888051,-0.03497922,-0.029875621,0.023001758,-0.024771193,0.026700243,-0.037158336,-0.0035549493,0.032595165,0.046832006,0.03914818,0.008008365,-0.14488566,-0.0009809767,-0.050022773,-0.06905335,-0.035671845,0.07197722,-0.02075847,-0.031818952,0.06586586,-0.03919468,0.039698947,0.05092622,0.012040582,-0.036784846,0.004525868,-0.04015969,0.009865716,0.05213436,0.07349686,0.06505461,-0.050400626,0.09453735,-0.046441432,0.043310415,0.039928608,0.030209402,0.0008624807,0.024440642,-0.02425188,-0.058144785,0.058087207,0.0070052124,-0.007146111,-0.03290487,0.037533112,-0.002336448,0.022958303,-0.06569502,-0.101606585,-0.08861681,0.0018106601,0.07267789,0.047892146,0.03208701,-0.061857324,0.012094714,0.021250037,0.079934545,0.111216664,-4.1969397e-08,-0.04016513,-0.05324286,0.04647168,-0.074719176,-0.0005647458,0.0106282635,0.0055016642,-0.0028935664,0.018028967,-0.014448959,-0.058186408,0.11661187,0.07026035,-0.024390312,0.07108973,-0.007822124,-0.009156788,-0.013301556,0.021393593,0.06283293,-0.046729017,0.05235195,-0.09580234,0.038760137,0.019503234,0.0091050435,0.054016132,0.034547463,0.058616687,0.042029243,0.028489016,0.03446529,-0.009083409,-0.07311784,-0.07063553,0.024236262,0.018524315,-0.03360826,-0.06185439,0.041320644,0.00267625,-0.03823486,-0.028201673,-0.00017670759,0.05729181,-0.013865822,0.07078745,-0.0064848433,0.03538307,-0.027037177,0.020288903,-0.052507848,0.021351676,-0.089101695,-0.10368657,-0.036482785,0.0074670976,-0.035946127,-0.04465329,-0.09420107,0.044483237,0.030831294,0.20539035,0.055031907 +1.3.3.6,A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18.,384,1.0,-0.07518482,-0.071715266,-0.054721657,0.022670139,0.07450126,0.022731481,-0.07378498,0.06491309,0.03606835,-0.09104188,0.032187715,-0.004309506,-0.07816859,-0.029115604,-0.03795328,-0.024027493,-0.0341714,-0.011503929,-0.073972985,-0.02760082,-0.02406319,0.022289876,0.03708121,-0.008847506,-0.013428441,-0.018592393,0.030651236,-0.0701163,-0.0057141357,-0.008728888,0.12264395,0.040533036,0.06180919,-0.004608494,-0.06489592,0.017726604,0.04753855,-0.047429413,-0.0007409622,0.009901,0.089508414,-0.06775073,0.037202325,-0.017967759,0.05862718,-0.043154996,-0.050829925,0.07221923,0.00072438805,0.07405358,-0.017111843,-0.053964406,-0.13495322,0.046578426,0.01949845,0.041750707,-0.05060427,-0.02895968,0.001951931,0.03384114,0.0047252784,-0.04533082,0.03635561,0.023944417,0.01938181,-0.08230586,-0.010586535,-0.025040515,0.07528368,-0.0047400855,0.0016143887,0.021237085,-0.08335014,0.037053034,0.037278686,0.08214115,-0.07696673,-0.041347247,0.05729761,-0.03800731,0.018020006,-0.0009467549,0.09927989,0.10439875,0.012186847,-0.037704397,-0.026241992,-0.011085643,-0.06890966,0.07712542,0.036127213,-0.014589401,0.010522091,0.05596448,-0.0811344,0.089995176,0.036694594,-0.062057365,-0.086334184,-0.0048913658,-0.051362816,-0.007282052,-0.016400335,0.013081595,-0.07078451,-0.06590578,-0.06928903,0.0454829,-0.0544257,-0.0316283,0.011655557,-0.04897588,0.051621124,-0.07504119,0.022169435,-0.035917833,-0.034734532,-0.048738547,0.020168256,0.0018043058,-0.045612667,0.08813421,0.0554015,0.065436356,0.014948664,-0.0040750275,-0.038219154,-3.0333962e-34,0.06602504,-0.024815163,-0.0071448283,0.028393699,0.026252726,-0.05720118,-0.05274725,0.010510315,-0.00087043183,0.021460231,0.010117842,0.019558696,-0.0064131673,-0.0027918564,0.07917238,-0.0020433667,0.02704302,-0.0113929985,0.07290708,-0.101015754,-0.009795514,0.04840627,0.057932585,0.0073851068,0.027034342,-0.0563283,-0.084735066,0.04953947,0.038633756,0.053711664,-0.05980887,-0.044488426,-0.0402831,-0.005168346,-0.016319357,0.032272212,-0.07788402,-0.08704764,-0.12306093,0.08764162,0.071243696,-0.040062502,-0.033084422,0.0006978094,0.022441838,0.01868035,-0.041464545,0.06763123,-0.022295538,0.076182984,0.04962612,-0.009315728,0.114655,0.05435682,-0.07966474,0.006896375,-0.070852205,-0.002898368,-0.013296738,-0.025797324,0.00969636,0.08686585,-0.01739784,0.08483334,-0.09212884,-0.015910124,-0.05404719,-0.04942884,-0.0087338025,0.095340155,0.10903098,-0.0047723665,0.072265714,0.015093835,0.06263953,-0.039682377,-0.049131073,-0.0132100545,0.014148097,0.03761347,0.009486515,0.03518635,-0.0014617633,-0.009634969,-0.041701313,0.020430766,-0.015540375,-0.016007336,0.03935154,-0.015371168,-0.018654605,-0.06838842,0.04992809,0.00399022,0.041549027,-3.98568e-34,0.04414085,-0.10959202,0.013715824,-0.0006323732,0.019197488,-0.020181881,0.03992649,0.005052695,0.0480451,-0.041328456,0.054879982,-0.061319917,-0.050148714,-0.0061197584,0.043400012,0.056870025,-0.037279624,-0.009259311,0.015436171,-0.0045890696,-0.062155075,-0.066208735,0.028034668,0.14205319,0.044502825,-0.0010621094,0.033611774,-0.0548881,-0.03183641,0.054229204,-0.033494674,0.0009708945,-0.054005813,0.012784125,-0.06218166,0.04024936,-0.006822451,0.029400997,-0.0030952012,-0.00030873923,-0.039569326,0.009081778,0.048557207,0.0024342043,0.0798554,0.017044434,0.00040421216,0.035445835,0.017979166,-0.055805974,-0.0019946452,0.03632542,0.011846982,0.07969629,0.01774761,0.07890487,0.036512997,0.09045976,0.048629835,-0.07302982,-0.029886872,-0.1039279,-0.021385616,-0.05096606,0.08469458,0.114120744,0.041494675,0.04094834,-0.03264173,-0.00113301,0.101063944,-0.0054098163,0.040521085,0.049609866,0.049519766,-0.06836952,0.0047110463,0.027181877,-0.04199374,0.033521418,-0.0019899637,-0.045247804,-0.017503234,-0.001015522,-0.07923999,-0.12746042,0.027026871,0.042041633,0.014536406,0.062905155,-0.032033443,0.03507358,0.008267807,-0.030488692,0.054675154,-2.2012209e-08,0.023323558,-0.08596034,-0.040089447,0.009561274,0.087986946,0.046559915,-0.08124712,-0.064858496,-0.0057182168,-0.021134755,-0.029109573,0.13380463,-0.0041375533,0.038613774,0.021019194,-0.07437707,0.007303021,0.014587463,-0.02370075,-0.07530875,-0.09886016,0.067347705,-0.006515902,0.015819691,-0.046011534,-0.033034664,-0.024582053,-0.0246358,0.052279692,0.0109212985,0.07399554,0.039937977,0.017956894,-0.010607704,-0.025184192,0.017180586,0.09917766,-0.050641846,-0.04772343,0.14233796,-0.06245672,-0.03416815,-0.0060206032,-0.040239446,0.004518547,-0.04772928,-0.009021307,0.056779128,-0.07248908,0.0046394104,-0.01332981,0.032597646,-0.04498934,0.016383046,-0.027687036,-0.10843827,0.007090953,-0.08474047,-0.06932167,-0.051556446,-0.004390682,0.0406256,0.12849098,0.00026301242 +1.3.3.7,Also oxidizes dihydrothymine to thymine. A flavoprotein (FMN).,384,1.0,-0.021665348,-0.009609934,-0.027077647,0.07430483,0.09553105,0.03524247,0.0018255237,0.044282477,0.017701907,-0.028973728,0.012563137,0.056182504,-0.060866922,0.018317413,-0.036954414,0.02794719,-0.074635305,0.030250905,-0.05179117,-0.036353048,-0.052651215,0.01200318,0.04976498,-0.023054352,-0.04898823,0.0047188182,0.020137044,0.013456419,-0.02987694,-0.036899645,0.05497347,0.057322036,0.0053116204,0.027355455,-0.09908075,0.07005217,-0.00068053004,0.00208246,-0.01258189,0.010673788,0.025156885,-0.047796667,-0.017970337,-0.03527891,0.0020412651,-0.020588355,-0.07469466,0.048237257,0.025251033,0.10776356,-0.028026678,0.046395287,-0.019359777,0.11279688,0.001962055,0.06273804,-0.056965377,0.03177994,-0.070544004,0.06880381,-0.049401283,0.014376842,0.0009403526,-0.009616994,0.085459106,-0.029482985,-0.023565456,-0.02305518,0.019037355,-0.020887773,0.07581906,-0.04107963,-0.026834732,-0.009493572,-0.033461805,0.05462881,-0.05711298,-0.06008264,0.026006902,0.053372417,0.013267493,0.038070325,0.03506266,0.09213136,0.08495001,-0.042303707,-0.087006584,-0.048473544,-0.046609815,0.078766145,-0.027808707,0.04174066,-0.018636106,-0.01760973,-0.021165496,0.06816138,0.04237035,0.018260326,-0.0665374,0.03740797,-0.027123254,0.002831712,-0.08952927,-0.021277886,-0.046162155,-0.020298399,0.022473054,-0.019855157,-0.0241197,-0.03306868,0.019230898,0.018579323,0.034214552,-0.028453223,-0.025981033,0.035065442,-0.019625245,0.0024475642,-0.043278467,0.02542261,0.01838646,0.03847598,-0.014702669,0.10192134,-0.008393567,-0.013029423,-0.0665026,2.0460038e-33,0.045434963,0.013930756,0.013958704,0.00225593,0.028981104,0.041735753,0.0088517815,0.0125747705,0.06603267,-0.044683315,-0.078603685,0.02676689,0.017625725,-0.043015048,-0.0015439211,-0.07574217,-0.07286085,0.02534676,0.095300235,-0.0567681,0.0896415,0.015025797,0.013037836,0.049387086,-0.0076926644,0.017364323,-0.036356673,0.04060464,0.011736969,0.02327949,-0.03051025,-0.0615695,-0.0054233577,0.0008044824,-0.011629274,0.023609927,-0.12454374,-0.04937388,-0.05341423,0.12117744,0.016171178,-0.023511073,-0.071963,0.034665518,-0.003679601,-0.02884284,-0.0839596,0.015676977,-0.020591421,0.0156647,0.0409969,-0.065684155,0.082983166,-0.027543234,-0.03397435,-0.008120636,-0.0020826545,-0.08601775,-0.01361421,0.06085266,-0.04706604,0.0076516722,-0.037035696,0.009097521,-0.0075453473,-0.065067045,-0.040396143,-0.033070497,0.004064477,0.021846205,0.031691812,0.012676618,0.13412939,0.008533738,0.022465548,0.008996396,-0.08322701,0.0013225682,0.004448347,0.004566363,0.046064653,-0.048815504,-0.02321383,0.046053812,-0.0038242964,0.008157143,-0.0072759534,-0.07867564,0.0031202498,-0.06475463,0.10052026,-0.073410444,-0.035502758,-0.12655659,-0.010953151,-2.0806948e-33,0.0013021355,-0.05235059,-0.037202243,0.056624454,0.0066417186,0.028335338,-0.014271875,-0.014205969,0.010641152,-0.0046864753,-0.0047001936,-0.08603623,-0.08247101,-0.05856203,0.001939909,0.050811008,0.017285904,0.09209401,-0.015305609,0.012239554,-0.06559218,0.022931483,0.03877483,0.093816005,0.085936174,-0.013021484,-0.0006238147,-0.027024824,0.066332586,0.09338875,-0.042365808,0.033130355,-0.04839695,-0.055275105,0.091048755,0.045458205,-0.038091186,-0.04265922,-0.0302488,-0.020013193,0.026462475,0.0011234245,0.081532955,0.050689638,0.033134002,0.072719164,-0.074424505,0.019506346,-0.017272241,0.017663801,0.0674198,-0.000467348,-0.0823026,0.05224551,0.05544825,-0.022693384,-0.011228689,-0.0044943527,-0.010515292,0.008838732,0.017653123,-0.09618121,-0.011550896,0.009922621,-0.012207975,0.03400685,0.022866778,0.12192459,0.027522355,0.06565047,0.0878805,-0.019327698,0.13642296,0.019457495,-0.012690158,-0.008493604,-0.024027025,0.0752215,-0.0052223206,0.003529262,0.019012574,-0.04653991,-0.008505769,-0.124805376,-0.032204844,-0.068914935,0.008714991,0.09675591,-0.012898182,0.06597125,-0.026922317,-0.016090188,-0.07432521,-0.0046084947,0.021382282,-2.3482107e-08,0.049159322,-0.11454801,0.055723984,-0.00021375796,0.038127594,0.0067239534,0.095169075,0.034992468,0.0058215363,-0.021468865,-0.00022292123,0.1079076,0.06244874,-0.037618507,0.033339705,-0.03473133,0.07179035,0.07569976,-0.04045045,-0.061647322,-0.113832556,0.07021459,-0.05055904,0.014462188,0.009454935,-0.012279134,-0.02477659,0.0041897898,0.1252733,-0.05380941,0.047758654,-0.005196975,0.026603142,-0.07955324,-0.09643395,-0.01545205,0.040190667,-0.0416414,-0.0533402,-0.020069955,-0.12729636,0.037799597,-0.042966835,0.019467607,0.024424741,-0.055977117,0.034546845,0.06442745,-0.023660783,-0.04062423,0.0114952065,0.029346846,-0.041525677,-0.07165478,-0.12137488,0.018365482,0.009870982,-0.046386,-0.030882811,-0.14188853,-0.052534163,0.08384946,0.19636403,0.014448278 +1.3.3.8,The enzyme from Berberis sp. is a flavoprotein; that from Coptis japonica is not. (R)-Tetrahydroberberines are not oxidized.,384,1.0,-0.07096798,-0.05357586,-0.17840317,0.018547203,0.06285814,0.05338977,-0.061988637,0.018874103,0.032679833,-0.033953924,0.042138174,0.048530333,-0.011561033,0.013778956,-0.060343776,0.02193439,-0.01294654,0.029067727,-0.05508268,-0.028955933,-0.033182483,0.032930307,0.03497018,-0.03586722,0.07013711,0.029273532,-0.04048219,-0.04173125,-0.011306424,0.010166483,0.0563976,0.12993634,0.065322824,-0.03355484,-0.017099341,0.05933755,-0.045726415,-0.043107618,0.0528989,0.0078046382,0.033580493,0.011277199,0.019756122,-0.0071668257,-0.016735453,-0.058576364,0.0066857236,0.07102306,0.023141183,0.08320734,-0.1166301,-0.013400922,-0.0580461,-0.012168563,-0.062245037,0.00012598821,0.06099222,-0.013194358,-0.02107159,0.017256819,0.008348545,-0.03997225,0.056286458,0.05563255,-0.016907312,-0.04400195,-0.054238092,-0.066182084,0.044079844,-0.062616944,-0.054052938,-0.046767317,-0.07928976,0.062422983,-0.015381709,0.101565756,-0.009556081,-0.07345111,0.01019708,0.03387975,-9.081888e-05,-0.015933625,0.059954923,0.06439683,0.045076255,0.031665638,-0.00688114,0.014143481,-0.030585997,0.02146517,0.0684238,0.080401,0.03631432,0.01426824,-0.06509076,-0.01980173,0.053463858,0.047793206,-0.084039755,-0.04464643,-0.029351799,0.011169989,-0.034759082,-0.10392128,-0.16362754,-0.00032349076,-0.0019085468,-0.008453447,-0.00851789,-0.024169752,0.017399108,-0.0021652218,0.037544474,-0.07601745,-0.007574007,0.09936484,0.035674766,-0.037967827,-0.031790547,0.054260097,-0.015356898,0.003972059,0.062089767,0.011382545,-0.028887216,-0.01880993,-0.022538386,1.3668599e-33,0.05048766,-0.0056502055,0.038327157,0.010813494,0.02561817,-0.010169379,-0.06317901,-0.039862484,0.020525858,-0.018854097,-0.08081438,0.0044023795,0.029388137,-0.029485816,-0.028421508,0.052230608,0.002838763,-0.10103398,0.043389834,-0.0052556647,0.09942076,0.11318588,-0.029272534,0.0023338664,0.041409876,0.011723365,0.028613552,-0.025478208,0.051729042,0.024328066,0.011146617,-0.100371264,-0.14798155,-0.009895668,-0.0332492,0.02220512,-0.066226244,-0.004601421,-0.105565235,0.05417764,-0.0002683807,-0.0051897946,-0.0055518784,-0.0060670283,0.07625397,-0.08263178,-0.028281655,0.048045382,0.017888844,0.0729508,0.05134903,0.018690126,0.13403897,0.069471814,-0.04093652,-0.00010559302,-0.00048417758,0.05616138,0.028543813,0.083198175,-0.0015628384,0.044462178,-0.0159681,-0.03629632,-0.030091273,0.018145042,-0.019734958,-0.060548827,0.005938349,0.0869828,0.06280876,0.015827514,0.11484096,0.061827548,0.05071627,-0.012774086,-0.061717566,-0.027784497,0.025530439,0.01889415,-0.049560893,0.014324421,0.075552724,0.044585075,-0.08453067,-0.017754372,-0.039348874,0.05792898,-0.07286432,0.0034750914,0.085330024,0.025803067,-0.06922761,-0.018872019,0.031635188,-1.8770643e-33,0.045726392,-0.0650199,-0.020571558,-0.0150156235,-0.09922559,-0.018643137,0.024232935,-0.04250687,0.05761954,-0.045299966,0.06933045,-0.051923882,-0.02983703,-0.0167612,0.052731548,0.0037430364,-0.02737849,0.045793504,-0.043751244,0.0056129764,-0.093810365,0.02534899,0.03987618,0.019855948,0.053815085,0.018286917,0.021311816,-0.006891794,0.036841296,0.06654405,0.026671236,0.03400198,-0.077910714,-0.023352189,0.007701196,0.046276283,-0.11289368,-0.024782455,-0.015091355,0.034770407,-0.012471922,0.025591811,0.047386907,0.052852385,0.05170411,-0.006143377,-0.100661255,0.026790876,0.005974223,-0.030201916,0.03208303,0.07820085,-0.031796478,0.03616893,0.13589768,0.03580098,0.004788912,0.0076143146,-0.035210997,-0.034528505,-0.01900811,-0.066408195,-0.040694974,-0.012113049,0.057632916,0.06916193,-0.004003003,0.06191983,0.0795182,-0.03857415,0.12439074,0.030628165,0.024919061,0.015013823,0.041656416,0.0023538156,-0.038471073,0.08651361,0.011368405,-0.05134653,0.007910307,-0.016986659,-0.0063090706,-0.049906086,-0.0048854477,-0.03643141,-0.041883066,-0.022402514,0.11582335,0.03967192,-0.013283042,-0.059530836,-0.08882585,-0.017948557,0.062428504,-2.9425983e-08,0.0028405725,-0.04462297,0.05836276,0.018749941,-0.020427767,0.04883425,0.010014708,-0.021512412,-0.014665309,0.004817539,0.04262234,0.04857554,-0.013486313,0.020902185,0.0015804028,-0.0063882563,-0.016462442,0.0075224186,0.004465393,0.0022636626,-0.06385247,0.012876768,-0.12551872,0.038093623,-0.06817343,-0.039236553,-0.032986276,-0.06409972,0.05196924,-0.054817352,0.038161423,-0.0042528072,0.03539651,-0.06992223,-0.14903334,-0.047336176,0.029298045,-0.02625506,-0.05829642,0.016722338,-0.061864126,-0.038257178,-0.04244599,-0.050467294,-0.028806075,-0.064762175,0.07177344,0.052043896,-0.020401208,-0.074449554,0.03431936,0.008274734,-0.007272017,-0.020413166,-0.059307527,-0.02130466,0.0042902506,0.010074876,0.0004784909,-0.11583017,-0.06252711,-0.012665491,0.16281067,-0.018650405 +1.3.3.9,A heme-thiolate protein (P-450). Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids.,384,1.0,-0.03685464,-0.053189512,-0.029302558,0.0002198545,-0.053425457,0.057920452,0.012702146,0.075538315,0.08102959,-0.020569323,0.0371547,-0.06701705,-0.056935932,0.013926654,-0.033658516,-0.022557594,0.026369281,0.039088298,0.013503286,-0.07830508,-0.048820585,0.05150655,0.03144019,0.010599,-0.0051924186,0.06696086,0.036757052,0.07270118,0.02912642,-0.018715141,0.032284252,-0.0092415605,-0.0025178073,0.010441522,-0.03167471,0.024444392,-0.07440889,-0.009821476,0.11337867,-0.009694699,0.07036568,-0.100046374,-0.05272895,0.05376018,0.005369798,-0.057111975,-0.07664319,0.036350053,0.06468327,-0.037051097,0.044996496,-0.052950587,-0.059016727,0.098137364,-0.03327882,-0.04485666,0.034717496,0.04411097,-0.009346388,0.058508936,-0.005536111,0.04714054,0.00024140584,0.013311913,-0.0139339445,-0.024261098,0.004076843,0.037299633,0.058423653,-0.0021084296,0.027257564,-0.028949114,-0.027838698,0.05969191,-0.08794741,0.070530355,-0.037695862,-0.0019092452,-0.111217216,-0.11855844,0.12636459,0.09657256,0.06026792,0.14191054,-0.002335449,0.016716506,0.031094134,0.064927936,-0.07134231,-0.042202614,0.037900925,0.06512578,-0.042331222,-0.011355361,-0.04248575,0.033859763,-0.023200883,0.020481994,-0.02017279,-0.021442326,0.031600643,0.048719876,-0.12925735,-0.05998103,0.005802375,0.01801559,-0.02307917,-0.040806673,0.089648314,-0.036484767,-0.020809606,-0.055145793,-0.017761385,-0.014152371,-0.002691333,0.049879458,-0.02283471,0.08732475,0.009530743,0.0063322843,-0.01080373,0.02432853,-0.04137074,0.036786206,-0.08495229,-0.063696764,-0.020008573,1.5374596e-33,0.09744495,0.020914622,-0.0273374,0.012666191,-0.03840949,-0.014187744,-0.05466572,-0.0056932173,-0.09415466,-0.027415989,-0.10782356,-0.070191756,-0.03636464,-0.016987795,0.0015810848,-0.06842634,-0.13129675,0.025607912,0.08289512,-0.09845044,-0.084953755,0.047689248,-0.037231456,0.019772053,-0.001187082,0.07552619,0.023119526,0.059636362,0.017056894,-0.025270956,-0.079203784,-0.025278049,0.0021213074,-0.04555643,-0.01642292,-0.055109955,0.03805746,-0.0046303635,-0.057204153,0.02960653,0.03269113,0.048977178,0.010290999,0.018931007,0.053115044,-0.029886084,-0.10712167,0.057988808,0.038630806,0.0024659438,-0.02533437,-0.040440004,0.07788693,0.05494361,-0.09997246,-0.021072237,0.0055381726,0.03780728,-0.020471357,0.02875898,0.08197839,0.02284924,-0.04573178,0.008706958,-0.028081663,0.09296809,-0.047058858,-0.021315088,0.01721877,0.07105996,-0.03866841,0.056592807,0.011841919,0.02316433,0.11265012,-0.007916921,-0.0006172264,0.07308343,-0.03422752,-0.022761092,-0.06256763,-0.049292974,-0.022480799,0.031322774,-0.056009725,0.008575184,0.019422371,0.059766777,-0.021034956,-0.00090044475,0.042431984,0.002106736,-0.05294829,0.07889988,-0.07824446,-2.0516318e-33,0.028426344,-0.04286406,-0.02139444,-0.03291872,-0.09849777,0.07976738,-0.07466096,-0.011155047,-0.042081665,0.065531775,0.110263616,0.011846085,0.07164363,-0.045712825,-0.05185389,-0.026590409,-0.0479235,0.06934297,-0.051656764,0.06303247,-0.027540782,0.032446813,-0.030500248,0.049394276,0.098943345,0.038752172,0.052586064,-0.01805439,-0.033765938,0.083149314,0.03918553,-0.0029598665,-0.14206046,-0.04974209,-0.08220067,0.0146652,0.053678136,-0.011004706,-0.022036642,0.012992683,-0.0373245,0.08783151,0.02774511,0.08794243,0.07706472,0.02721405,-0.032774154,0.006091676,-0.05647156,0.014603765,0.018570522,-0.002397527,0.038477782,0.0073316623,-0.0147818,-0.03170794,-0.03015793,-0.016061237,0.049394235,-0.04608709,-0.0009590184,-0.04533765,0.01392053,0.016524866,0.014379041,0.051875304,-0.009733842,0.089636594,0.097812854,-0.045329623,0.06732385,-0.010629102,0.030565327,0.026538225,-0.018062897,-0.0121009825,0.07408083,-0.052820873,-0.00020690917,0.009960605,-0.030884346,0.04663153,-0.037982695,-0.062238004,-0.02173696,0.0205911,0.018729666,0.11241408,0.018650351,0.024402268,0.0004353828,0.05684117,-0.031994224,0.040784072,0.027407182,-2.7299563e-08,0.062460154,-0.034545153,-0.0055382424,0.042528197,0.040869597,-0.023770094,0.028822199,-0.019192273,0.0073451013,-0.025945202,-0.041796472,0.017601613,-0.043401264,0.035420436,-0.006751672,0.014529758,0.05040611,0.06345806,0.03442907,0.006725001,-0.023148514,-0.0056824237,0.02967418,0.005572723,0.01410872,-0.09573627,-0.019701716,-0.025502264,0.034309622,-0.025343828,-0.0067980317,0.042887535,-0.022111509,-0.015243087,0.0304981,0.10285677,-0.055711932,0.014252958,0.0013983275,-0.036145866,-0.049048312,-0.11599733,-0.03148594,-0.033516288,-0.00513521,-0.015863141,0.08817275,0.046264403,0.028312378,-0.06386685,0.018957943,-0.032549273,0.02362035,-0.07720774,-0.14294018,0.029370239,-0.03653862,-0.009677798,-0.00928654,-0.15103263,-0.02719207,-0.05906646,0.1250771,0.021034254 +1.3.3.10,"Requires heme. The enzyme from Chromobacterium violaceum is specific for tryptophan derivatives possessing its carboxyl group free or as an amide or ester, and an unsubstituted indole ring. Also catalyses the alpha,beta dehydrogenation of L-tryptophan side chains in peptides. The product of the reaction can hydrolyse spontaneously to form (indol-3-yl)pyruvate.",384,1.0,-0.009445649,-0.048127048,-0.08849572,0.026243288,0.02241086,0.13093035,-0.029990876,0.05177201,0.04641199,0.067161426,-0.01394277,-0.07817867,-0.17283423,0.07128172,-0.026872547,0.08794774,-0.05112299,-0.0009915602,0.033005793,-0.03720948,0.021128593,0.03896593,-0.003543919,-0.008259865,-0.04800334,-0.008016049,0.030721996,-0.002268179,0.047091838,-0.023348266,-0.018061426,-0.031831633,0.04920216,-0.05106596,0.08038291,0.110130765,-0.06283544,-0.1159413,0.03848248,-0.014196236,0.039145693,0.022760669,-0.08910093,0.021676637,-0.05244765,0.009538704,0.074313216,0.065733895,0.014595252,-0.044702683,-0.013106581,-0.06333153,-0.08322432,0.012702493,-0.06285257,0.07020076,-0.00079438963,0.0069117006,0.051552154,0.031063167,-0.061733354,0.069400676,0.044449184,-0.008230165,-0.003654033,-0.070360795,-0.018053746,-0.05076685,0.0062990044,0.0026688334,-0.061860655,-0.08806071,-0.040956765,0.05559824,-0.048873663,0.021291992,0.0063555925,-0.038112257,-0.008668612,-0.061002564,-0.0442763,-0.022936651,0.00640349,0.12223415,0.0004315307,0.03896625,-0.04405906,0.01489196,0.0428254,-0.0066921087,0.052651566,-0.0005813676,-0.023882158,-0.084629335,0.025227556,0.030673133,0.04743338,-0.07712315,0.050662216,0.00063601206,-0.0041474076,0.00401938,-0.022947133,-0.095976695,-0.058488928,-0.0158325,0.0216235,0.052669853,0.09130405,-0.007992091,-0.04689774,0.030945068,0.06505564,-0.013730237,-0.0542279,-0.0007335291,0.003161523,-0.08234665,-0.029704496,0.0135120675,0.07156772,-0.07221827,0.06439784,0.060927067,-0.07992545,0.02261792,-0.086592525,3.7143326e-33,0.114892416,0.003312416,0.02629583,0.0020251372,-0.07340794,0.0338307,-0.07915069,-0.03189299,0.002437827,0.0144596705,-0.052011825,-0.12215631,0.057999715,-0.024761083,0.022835374,0.021961818,-0.12129765,0.012394383,0.033679876,0.013760292,-0.07314887,0.010393642,0.013953834,0.012976849,-0.031952266,0.04933761,0.020635929,-0.0121695,0.0767068,-0.014581347,-0.014169874,-0.010301579,-0.1178271,0.012606897,0.034767516,0.039941087,-0.04745417,-0.029563569,-0.057255317,0.060982984,0.02143955,0.0496588,-0.0022407668,-0.027476145,0.1244922,-0.04389356,0.010433857,0.08935922,0.0521237,0.03523017,0.02498838,0.0031354318,0.08547326,-0.03413454,-0.03719058,-0.0047433367,0.021407163,0.007288289,0.07376226,0.03813824,-0.036423445,0.04231112,0.006976827,0.011811596,-0.04954999,-0.010677187,-0.058151253,-0.096216165,-0.025521921,0.0047389814,-0.040050726,0.003836305,0.059656803,0.00044078307,-0.028139586,-0.08200431,-0.033568736,-0.014693224,0.03915416,-0.046317417,0.04555882,-0.036235064,0.032773506,-0.03755837,0.025608493,-0.05812692,-0.053040605,-0.040592317,-0.052277546,0.015484753,0.058052156,-0.041799825,-0.056971982,0.06137823,0.042331457,-4.6883413e-33,0.028687386,-0.11618394,-0.058389712,-0.07300931,0.01119537,0.029349372,-0.001266356,-0.053691324,-0.013025078,-0.014330073,0.06867483,-0.01750476,0.0004790186,-0.02339626,0.050030783,-0.025219893,0.0033861483,0.09694446,-0.017473334,-0.07272509,0.015281957,0.056719977,0.04546404,-0.0042466796,0.079134054,0.040623493,-0.061735563,0.09377927,0.010492165,0.03789441,0.039151434,-0.014889259,-0.10882564,-0.034863565,0.04428034,0.046917077,-0.05236452,0.05655272,0.052039634,0.009833217,0.006980455,0.061856084,0.091899335,0.057452425,0.01818852,0.080285445,-0.08164253,-0.0026311942,0.0250853,-0.011840329,2.1021975e-05,-0.07573254,-0.05645257,-0.049048387,0.030000618,0.070301816,-0.018062336,0.0054935426,-0.049710862,-0.02459414,-0.05468546,-0.018273624,0.09273927,-0.021847134,0.004034758,0.062724695,0.03416202,0.088024005,0.0771348,0.005109969,0.052763492,0.04564447,-0.0027578524,0.06621531,-0.023987645,-0.02751887,0.009097911,-0.062134705,0.060230028,-0.06816762,0.027401542,0.043375347,-0.004514736,-0.01994303,0.0060210233,-0.09929674,-0.018500667,0.08791981,0.005162291,0.021684313,0.005391727,-0.056540664,0.022870025,0.0743654,0.119550854,-4.3796508e-08,-0.0027039226,-0.093587235,0.008673281,-0.026085949,0.047767133,-0.0049091945,-0.036983132,-0.028993592,0.06800434,-0.09784342,0.010553038,0.015203312,-0.0085569145,0.06414286,0.042460546,0.028120693,-0.03198967,0.0567624,-0.055248443,-0.014225028,-0.08173213,-0.010345823,-0.045159057,0.03245284,-0.0032159614,-0.09085019,0.015152436,0.014487352,-0.012377935,0.028302202,0.018534508,0.038186524,-0.036993384,-0.009113856,-0.03350134,0.08758586,-0.04192703,-0.0041302,-0.052503955,-0.030040883,0.00306688,-0.022236511,-0.03743536,-0.0013579355,-0.007915268,-0.041081574,-0.044609547,-0.0013053108,-0.00712924,-0.019028498,0.03046041,-0.047447544,-0.024955647,-0.0027882948,-0.064461365,0.01222608,0.016877484,-0.04502003,-0.008035919,-0.089400366,0.04410427,0.056683425,0.21289112,-0.0041849287 +1.3.3.11,"So far only a single turnover of the enzyme has been observed, and the pyrroloquinoline quinone remains bound to it. It is not yet known what releases the product in the bacterium.",384,1.0,-0.08194294,-0.058070846,-0.03880217,-0.060689647,0.046656366,-0.0012852737,0.0033509755,0.072581924,0.023654869,0.028713003,0.043545496,-0.04419288,-0.009958523,0.048223555,-0.08542899,0.08818362,-0.08845139,-0.07584471,-0.0027153618,-0.0033949844,-0.030575547,0.014172067,-0.0107100615,0.024964992,0.019362796,-0.000119222736,0.02700986,0.0012388943,-0.049455583,-0.024881825,-0.015774101,0.0051838355,-0.036468793,-0.048589677,0.08056557,0.10093019,-0.047205154,-0.0051597776,0.10517933,0.04049636,0.076370664,-0.049126796,-0.0032194078,0.022782948,-0.016789231,0.07111405,0.07246108,0.07612005,0.021259354,0.0035605975,-0.050846424,-0.055319186,-0.016630813,0.10152964,0.010037537,0.027272932,0.041600153,-0.011664714,-0.065777704,0.033704914,-0.00834234,0.0068772472,-0.040960595,-0.027704537,0.01241199,-0.008797424,0.009776485,-0.06728514,0.037079554,0.007973878,0.006983661,-0.06698896,-0.014882562,-0.031201376,0.016179048,0.048149418,-0.0062050754,-0.036051314,0.049353335,-0.044345748,0.018069705,-0.054755054,0.018960545,0.035979025,0.0023300557,-0.043619346,0.05528086,0.008960849,0.057629563,0.052068006,0.017822457,0.038236246,-0.012106183,-0.10219768,-0.065791,0.029782945,-0.027011951,0.023635892,0.032679074,-0.03156642,-0.058343403,-0.018354833,-0.07993275,-0.1458584,-0.11124043,0.008022064,0.0069768187,0.052159496,0.049539264,0.0110515235,-0.017855708,0.058576245,0.0489258,0.018970575,0.02021477,0.10176465,0.105747625,-0.008094461,-0.09771027,0.04134027,-0.035546303,0.017112197,0.1305057,0.03804535,-0.053037576,0.047895007,-0.00058132346,-5.8844495e-35,0.02491566,-0.056656737,-0.0012258916,0.02865269,-0.006487672,0.043248452,-0.09095474,0.023572363,-0.059988916,-0.11224768,-0.05876638,-0.10950214,-0.020764919,-0.0061458135,-0.08476479,0.027704922,0.02541886,0.012715701,0.027407195,-0.03246136,0.044229254,0.039374907,-0.04332352,0.018063778,0.03831412,0.05932509,0.002187076,0.08569655,-0.02674509,-0.030839907,0.018979125,-0.031524092,-0.12076055,-0.04898367,-0.0049937903,0.00986081,-0.08432386,-0.007991339,-0.047142405,0.0594846,0.0029001958,0.063194044,0.027040832,-0.043081403,0.007030344,-0.0908564,-0.024678256,0.06872708,0.03548752,0.029573912,0.038899455,-0.0059892717,0.060535837,-0.028631475,-0.10399371,0.004520083,0.03408876,-0.032418344,0.09174655,-0.018595245,0.05537696,0.14498027,-0.034092464,-0.031265274,0.017509291,0.05860296,-0.04342133,-0.036524143,-0.025007136,0.097627915,-0.02403676,-0.014671889,-0.003095147,-0.057010435,0.0148674715,-0.050755266,-0.07981584,-0.07527473,0.012409394,-0.023224222,0.025075126,-0.08458933,0.0912104,0.023312585,-0.047586467,-0.0127546135,-0.018014781,-0.00838535,-0.0155522,0.048955403,0.04876949,-0.04679767,-0.07103079,-0.004497761,-0.003128892,3.0647686e-34,0.020609438,-0.061326858,-0.009342842,0.003359044,-0.012936082,0.07646568,-0.011481466,0.047333073,-0.00512154,-0.047778443,0.07311298,-0.030426657,0.010874955,0.04012268,0.01395189,0.0002763864,-0.00371086,0.04156719,0.05299628,-0.012794639,-0.021050712,-0.051219676,0.03370081,0.0114863645,0.023611242,0.03959097,0.004201933,0.110341445,0.018424153,0.024893556,-0.0023688804,-0.01768489,-0.010397876,-0.039986286,-0.0071899276,-0.0125168245,0.005625433,-0.011895251,0.050510697,0.01542676,0.04268671,-0.0051864474,-0.012395352,0.07172788,-0.025155518,0.060529087,-0.027406396,0.047563616,-0.005456288,0.01606455,0.06739027,0.049804967,-0.060191076,-0.045575686,0.048409816,0.053657208,-0.013105838,-0.012167418,0.02030503,-0.061287817,-0.075081274,-0.06674269,-0.037807647,-0.016040057,0.08577164,0.13107084,0.00481132,0.12758692,0.017188206,-0.03238044,0.121174425,0.042935297,-0.011561631,-0.011690642,-0.051965047,0.09371147,0.004478895,-0.062282596,0.09903701,-0.026918286,-0.006331523,-0.062209032,0.0050802566,-0.08666724,-0.0121677555,-0.10118965,0.027753294,0.011418531,-0.002960978,0.04249059,-0.018079717,0.009841569,-0.010061831,-0.00060765474,0.092376895,-2.9574249e-08,0.069787204,-0.052915737,0.07655707,0.0404021,0.04787906,-0.005509851,0.052447326,0.055142645,0.04613332,0.0065265,-0.0012972447,0.026042325,-0.023679689,0.05672645,0.07676623,0.04581207,-0.03476453,-0.055456575,-0.06923943,-0.05996517,-0.06170249,0.030130552,-0.06693072,-0.06394286,-0.026902616,-0.05520709,0.024411228,0.06447482,-0.10856942,-0.07850488,-0.0035824438,-0.0046348437,-0.026997093,-0.031569235,-0.032962196,0.036564153,-0.104461,0.02752579,-0.0027829695,0.02446429,-0.0412385,-0.00022626203,-0.0794738,0.030726627,-0.012227561,0.023461403,-0.01551366,-0.014097347,-0.013751468,0.0076174214,0.12333048,0.0064005665,0.082697466,-0.010560124,-0.09433195,0.05829289,0.023615967,-0.08588798,-0.04594354,-0.09335285,-0.024088608,-0.061050147,0.16228072,-0.0033046014 +1.3.5.1,"A complex generally comprising an FAD-containing component that also binds the carboxylate substrate (A subunit), a component that contains three different iron-sulfur centers [2Fe-2S], [4Fe-4S], and [3Fe-4S] (B subunit), and a hydrophobic membrane-anchor component (C, or C and D subunits) that is also the site of the interaction with quinones. The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of bacteria and archaea, with the hydrophilic domain extending into the mitochondrial matrix and the cytoplasm, respectively. Under aerobic conditions the enzyme catalyses succinate oxidation, a key step in the citric acid (TCA) cycle, transferring the electrons to quinones in the membrane, thus linking the TCA cycle with the aerobic respiratory chain (where it is known as complex II). Under anaerobic conditions the enzyme functions as a fumarate reductase, transferring electrons from the quinol pool to fumarate, and participating in anaerobic respiration with fumarate as the terminal electron acceptor. The enzyme interacts with the quinone produced by the organism, such as ubiquinone, menaquinone, caldariellaquinone, thermoplasmaquinone, rhodoquinone etc. Some of the enzymes contain two heme subunits in their membrane anchor subunit. These enzymes catalyse an electrogenic reaction and are thus classified as EC 7.1.1.12, succinate dehydrogenase (electrogenic, proton-motive force generating).",384,1.0,-0.068814136,-0.01741819,-0.11875998,0.008111647,0.08180993,-0.0064330124,-0.054842733,0.030986639,0.045770764,-0.0508838,-0.011914035,-0.08100657,-0.015401151,0.0051662894,-0.04920842,-0.022752343,-0.0749035,-0.006461463,-0.058975592,-0.035186674,0.04470655,-0.02455006,-0.051069878,-0.056079186,-0.02757073,0.01594265,0.033369046,-0.011420514,-0.09889482,-0.00588335,-0.050468493,-0.02544741,0.041939978,0.009399194,-0.02003112,0.16410187,-0.027496297,-0.027048256,0.03725365,-0.03533703,-0.014958114,0.037946865,-0.00059419207,0.018792892,0.032419242,0.0029818108,0.042795744,0.02553339,0.016986057,-0.03578987,-0.056425482,-0.027683556,-0.05310722,0.11404798,-0.011543336,0.059432533,-0.032339867,-0.066632606,-0.05669242,0.037855413,0.024676684,-0.038325988,-0.00587454,-0.010046,0.03309292,-0.053619456,0.0060735354,-9.037811e-05,0.03572433,-0.037429284,-0.0952664,-0.022231082,-0.042449113,-0.015222051,0.023422543,0.06431507,0.029679567,-0.04406468,0.043708313,-0.029672131,0.021775242,0.027165394,0.09244927,0.03698524,0.09636681,-0.007712461,0.046717525,-0.023813993,-0.001839893,0.089905925,0.060933784,0.021274682,-0.007618972,-0.060814783,-0.04610539,0.02605935,0.0030145585,0.08308563,0.018187268,-0.010611152,0.02336011,0.064507656,0.03320381,-0.09520932,-0.022561612,-0.015124005,0.029658852,0.119158655,0.0018395175,0.014459089,-0.011899894,-0.0011399299,0.07724038,-0.009811102,0.043133948,0.12975334,0.058195394,-0.031533565,0.010143184,0.012541683,0.006612903,0.004854867,0.044433318,-0.010844953,0.028330473,0.0014254771,-0.13481884,1.34531315e-33,0.024026502,0.0074375267,0.02534028,0.031787556,-0.02841823,-0.04021644,-0.11280413,-0.010908555,-0.02781828,0.06759866,-0.053904343,0.0029291469,0.02824861,-0.051957946,-0.012964119,-0.05135243,-0.077313304,-0.020724514,0.058132336,-0.04252354,0.026127016,0.019758144,0.02933695,-0.068868116,0.06137759,0.017631829,0.0010206049,0.034683734,-0.0014815602,0.0013519403,0.05480842,-0.09966517,-0.121890955,-0.018121947,0.0005552866,-0.013140376,-0.056080233,-0.006822813,-0.08763698,0.07874539,-0.024467742,0.053801022,0.0025274812,-0.0017614983,0.0363474,-0.08856975,0.009260127,0.1316857,0.0553802,0.041310184,0.0132239675,-0.057539076,0.12989534,-0.03379027,-0.02675769,0.0455075,-0.0071199383,0.0018079161,0.041563727,0.09131325,0.07600561,0.023013115,-0.08257723,0.08863497,0.039072044,0.076504774,-0.12840796,-0.025460854,0.0610897,0.12997103,-0.060495008,-0.041611955,0.08201631,0.00028164714,0.036628857,-0.031152707,-0.050945755,-0.035884246,-0.06965152,0.00787248,0.028636076,-0.06314439,0.005903617,-0.022694623,-0.063924596,-0.05597742,-0.0041107237,-0.04004143,0.0053830156,-0.07451332,0.029386042,-0.0055343094,-0.03136546,0.0045687025,0.029242983,-1.4206993e-33,0.09296084,-0.12859643,0.06629541,-0.101246834,-0.027784448,0.11046696,0.021076865,-0.07349852,-0.0062280097,-0.04471824,0.04602883,0.01544421,0.026701095,-0.0072148712,0.05657081,0.0070401886,-0.021931564,-0.017462146,-0.019796103,0.0051515223,-0.018684633,0.097375065,-0.00065068493,0.04378079,0.022088649,0.010832169,0.0059001776,0.048899557,0.0479541,0.03251347,0.005761571,-0.009972672,-0.014231691,0.0030279097,-0.058648847,0.0006783559,-0.0023173785,-0.016673453,0.057630215,0.07406814,0.02268346,0.006710567,0.0002774828,0.045045476,0.029466653,0.075801484,-0.12299967,0.016163923,-0.014842276,-0.03644854,0.03546874,-0.05581604,-0.088269174,0.0021247307,0.092243,0.06457601,-0.00088280946,-0.047152303,0.01051258,-0.027052058,-0.03279507,-0.10465096,0.03707662,-0.0496746,-0.0099388305,0.0012223097,-0.05593548,0.058453538,0.021271328,0.036108088,0.012224504,0.024700707,-0.032848425,-0.0077514113,-0.026758218,-0.022185305,0.0037715456,0.029381638,-0.0005974309,0.04034343,-0.023816742,-0.012174028,-0.038607176,-0.07573305,-0.008908926,-0.08715964,0.050243985,0.06238398,0.019425409,-0.02580966,-0.0019991538,-0.018497461,-0.019547062,0.08956703,0.035981964,-4.6754955e-08,0.018071642,-0.03627275,0.07854184,0.012055358,-0.04690036,0.07068096,0.048791457,-0.043471713,-0.01150014,0.051119644,-0.010138875,0.10604389,0.035050526,-0.043210365,0.027286563,0.058418106,-0.05342761,0.02888364,-0.013297254,0.0019808628,-0.0035684363,-0.031943664,-0.11687236,0.080925874,0.08315565,-0.084773436,0.0004726915,-0.02457018,-0.0267569,-0.025628317,-0.039039653,0.031535838,0.057510275,-0.03388774,-0.10968199,0.016397078,-0.023801716,-0.046925895,-0.07786846,0.029349167,0.06539432,-0.04054898,-0.119105384,-0.017002275,0.02004581,0.033711113,0.01944734,0.05010882,-0.039715294,0.021339431,0.043067407,0.024029626,0.0314037,0.05492599,-0.049726374,0.08517064,-0.03236832,-0.056550387,0.02788787,0.0004963585,0.0815012,0.03466041,0.11772537,-0.080756 +1.3.7.2,"Catalyses the two-electron reduction of biliverdin IXalpha at the C15 methine bridge. It has been proposed that this enzyme and EC 1.3.7.3, phycoerythrobilin:ferredoxin oxidoreductase, function as a dual enzyme complex in the conversion of biliverdin IXalpha into phycoerythrobilin.",384,1.0,-0.054191872,0.019937068,-0.059420712,0.010373877,0.061733272,-0.015891556,-0.080888085,0.035025794,0.03102929,-0.019425195,-0.03478472,-0.043377176,-0.026756259,-0.0027285323,-0.059963364,0.0025531338,-0.104853466,0.02699746,-0.021302288,0.016322454,0.041129783,-0.034603603,-0.0060669216,-0.0322404,0.0070954734,-0.009128556,0.048673365,0.049290694,-0.027861292,-0.060867514,0.001591033,0.00024928842,0.026486153,-0.09561764,-0.025310626,0.059906427,0.008996458,-0.04774009,0.09951056,-0.04431872,0.036798783,0.032303397,0.00091374473,-0.07727513,-0.037598576,-0.0043508396,0.0028723394,-0.037956852,0.07010875,-0.0071878876,-0.050932582,-0.0035023466,0.011022148,0.031050758,0.041632406,0.006717494,-0.10223951,-0.030387562,0.067134745,0.09040797,0.07067849,0.020618506,-0.0017425026,0.055562805,-0.031467,-0.078400284,0.0180825,-0.091780454,-0.021251723,-0.08441097,-0.044531617,-0.006508974,-0.012531068,-0.059017606,0.034192353,0.0600104,-0.02203669,-0.053678397,0.05281194,-0.012356673,-0.0831554,-0.040817887,0.030626792,0.09240205,0.044318378,-0.0037159382,-0.04493285,-0.04716428,-0.047323413,-0.010477766,0.02671342,0.04050591,0.04634241,0.0070188884,0.010800453,0.07339349,0.06437786,0.08369437,-0.0035947186,0.035984565,0.0036686442,0.119010635,-0.00010690873,-0.09174766,-0.060494553,-0.012402165,0.04406009,0.084407635,0.008724305,-0.024505822,0.043214656,-0.080029674,0.09693582,0.017180722,-0.008880546,0.16909683,0.0028229142,0.002972324,0.0093532,0.020384086,0.03941277,0.005823276,0.028096858,0.030929253,-0.008011408,-0.0061841006,-0.01830196,5.8790117e-33,0.03623702,0.0926967,-0.03769157,-0.036479257,0.0019431623,-0.06268684,-0.10354651,0.07004728,-0.053733714,-0.025787758,-0.0015110858,-0.049993925,0.052683458,-0.055803545,-0.0923794,-0.097792074,0.010643835,-0.050006203,0.0629541,0.013297607,0.08000963,0.041591626,-0.02334202,0.0748979,0.0041043423,0.020118274,0.030855535,0.003736521,0.0156235285,0.010889661,0.012299201,-0.024547296,-0.076571755,0.04280364,-0.051207393,0.007204109,-0.062007606,-0.039942417,-0.036676824,0.073779844,-0.029026996,-0.028166903,-0.030408485,-0.093757324,0.07272616,-0.055253975,-0.080409415,0.0660751,0.08659734,0.104774125,-0.0016863516,-0.0031841057,0.058852144,-0.019330157,-0.061350256,0.039090313,-0.046349276,-0.0149738,0.05118428,0.062766075,-0.0031725946,0.01663872,0.02680529,0.031454373,0.0297481,0.03246335,-0.0032835552,-0.13305624,-0.05201542,-0.024513949,-0.041943643,0.028073423,0.029831072,0.008253009,0.11900196,0.02206788,-0.07858746,0.0006322453,0.07686051,-0.033247102,0.0012409695,0.0578508,0.057078175,0.02002997,0.09051195,-0.065544255,-0.059278443,-0.008089231,-0.00921677,0.0062808455,0.037199073,-0.098287605,-0.09122834,0.0045700585,-0.018987453,-4.9350636e-33,0.050953586,-0.052940283,0.01794039,-0.03214799,-0.07011415,0.06814255,0.050186653,-0.07390123,-0.00657815,0.004635775,0.17111728,-0.01614377,0.015779605,-0.04240163,0.0024374214,0.02148579,0.0715621,-0.019328944,-0.001355273,0.037584968,-0.03588818,0.0449316,-0.010002858,-0.019422982,0.043602947,0.039680157,0.028818043,-0.055895872,0.086940326,0.05504461,-0.054574188,0.0019616731,-0.043496545,-0.03916004,-0.013314214,0.11717941,-0.04582183,0.028323753,0.021222068,0.01644735,0.024843866,-0.032755595,-0.014854611,-0.050550465,0.0376874,-0.010579605,-0.058050882,0.036453694,0.0050613787,0.022437658,-0.026064528,0.07396871,-0.02677126,-0.026371315,-0.028961971,0.061565302,0.12129307,0.03029627,-0.016279532,-0.061440185,-0.037802204,0.0032311282,0.1019267,0.059403613,0.028368585,0.06438146,-0.06346889,0.055772796,-0.0008129036,-0.0857297,0.0220132,-0.021578284,0.10846142,-0.00018223703,0.029138042,-0.07275751,0.051621728,-0.046829958,-0.015465044,-0.0015860524,0.0094677005,0.0016103582,0.008782987,-0.12960218,-0.036222484,-0.078165226,-0.02325815,0.05142938,0.01905083,-0.032793213,-0.0033632743,0.021350883,-0.08080845,-0.030157724,0.10060114,-3.6556656e-08,0.057538234,-0.014474047,0.008335236,-0.028074047,0.015520356,-0.032785863,0.0005154246,-0.020719048,-0.038120274,0.0319282,0.02435961,0.06979544,0.026141904,-0.051584788,0.0110498695,0.04247285,0.003000345,-0.013007783,0.0005453309,-0.04508737,0.019557387,-0.08009986,-0.082324326,0.038174864,-0.004216909,-0.13527061,-0.010827237,-0.07873619,-0.018883985,-0.06275825,-0.025983201,0.09933311,0.013718252,-0.027377373,-0.041581158,-0.0105723655,-0.02540539,-0.018944321,-0.05149329,0.01120673,-0.022162661,-0.035424482,-0.045640096,0.000941403,0.074183956,0.028675122,0.021279784,0.04599457,0.08812496,0.021709146,-0.014232428,0.012143289,0.076854944,-0.047296915,-0.044843785,0.099466495,0.006619,-0.0030720702,-0.024382817,-0.013806674,-0.042203337,-0.004340717,0.13446759,-0.10136678 +1.3.7.3,"Catalyses the two-electron reduction of the C2 and C31 diene system of 15,16-dihydrobiliverdin. Specific for 15,16-dihydrobiliverdin. It has been proposed that this enzyme and EC 1.3.7.2, 15,16-dihydrobiliverdin:ferredoxin oxidoreductase, function as a dual enzyme complex in the conversion of biliverdin IXalpha to phycoerythrobilin.",384,1.0,-0.041569382,0.05901518,-0.042090196,-0.0564598,0.11144955,-0.038635764,-0.05881617,0.045416404,0.06104899,-0.027009793,0.0028281794,-0.03815367,-0.058106337,0.0019675458,-0.080098726,0.0048443037,-0.086188816,0.032460447,-0.049114317,-0.0058354675,-0.03579952,-0.082516655,-0.046075746,0.00027914695,0.029670065,0.01934173,0.03118545,-0.008161828,-0.06713144,-0.032055333,0.057551563,-0.042960785,0.038958944,-0.08828059,-0.030854799,0.07615268,-0.005624545,-0.07669043,0.05160036,0.012361075,0.0063874787,0.042799316,-0.055837523,-0.04129448,-0.049214564,-0.07088506,-0.045935974,-0.005293029,0.067153186,0.0051781586,-0.06750194,-0.019876907,0.022163063,0.072390385,0.058842834,-0.029360332,-0.06280394,0.026839307,0.005974314,0.073114984,0.00954602,0.009366005,-0.025581049,0.025825165,-0.055650137,-0.06404159,0.053088,-0.059717815,-0.02992734,-0.05117678,-0.045259643,-0.029205576,0.021449367,-0.001399684,0.050196458,0.069503926,-0.0075383144,-0.0033614289,0.03860675,0.0023912059,-0.050968308,-0.027701817,0.03565838,0.051775858,0.027540054,0.002953994,-0.050001904,-0.041552458,-0.0006274127,0.019732883,-0.021609362,0.040335853,-0.009322302,0.019561036,-0.018538468,0.09082801,0.06275115,-0.0058976864,0.019004889,0.009264078,-0.009213237,0.12058028,0.014824314,-0.10434973,-0.030235812,-0.019327784,-0.0029944351,0.055429026,-0.012231362,-0.019227486,0.060753446,-0.07658051,0.07803344,0.02168593,-0.015568286,0.14251453,-0.038530294,0.005429782,-0.005089282,-0.013458908,0.027299266,0.0055905157,0.067479454,0.032068707,-0.0040684454,-0.041757703,-0.037995394,3.9367776e-33,0.09777041,0.0700715,-0.053717636,-0.0032579105,0.022819053,-0.056307986,-0.062087074,0.13111846,-0.047417447,-0.02245086,-0.03323057,-0.12568659,0.07265996,-0.08366949,-0.07208961,-0.10600328,0.007214886,-0.052798644,0.0645149,0.026423438,0.068904646,0.037178755,-0.008197035,0.037556857,0.058306172,0.03670327,-0.019904895,0.045051463,0.08453567,-0.004600801,0.009724751,-0.047933567,-0.08845701,-0.0065369224,-0.016882492,-0.0051512555,-0.025787864,-0.05003285,0.023737479,0.032247253,0.026977146,-0.033136632,-0.016162736,-0.07249562,0.10983948,0.020299353,-0.006627242,0.038061872,0.0788803,0.032390784,0.035807066,-0.0002020993,0.04719684,-0.05473402,-0.08067964,0.045790162,-0.07128563,0.005190509,0.08811256,0.07359093,-0.0297784,0.045602523,0.049053628,0.008174935,0.027286388,-0.0026962515,-0.040451847,-0.10070974,0.0006367877,0.010105964,-0.06791415,0.010201279,0.08207497,-0.04330324,0.1342125,0.008567688,-0.10125709,-0.021699931,0.07656923,-0.02013458,-0.009425947,0.025376571,-0.012232282,-0.035994697,0.004875879,-0.030140193,-0.067637585,0.0057624546,0.0006578325,0.025829317,0.010462712,-0.0959935,-0.041655947,-0.015207363,0.0079051675,-4.59487e-33,0.07288952,-0.058944922,0.029166678,-0.027803622,-0.020832794,0.068669885,0.03623421,-0.060313024,0.004747835,0.03342487,0.16358949,-0.037765644,0.0003017526,-0.05402536,-0.027732737,0.046232942,-0.05362479,-0.001896091,-0.0066108415,0.036624923,-0.039507102,0.013374239,-0.023597924,0.009807319,0.06966867,0.023258572,0.01397897,-0.053017084,0.09461277,0.042305645,0.005411678,-0.012228855,-0.04138485,-0.010416001,-0.010827165,0.10832467,-0.09750499,-0.021150056,0.042282514,0.06935215,-0.019161992,-0.070715256,-0.001645306,-0.012947696,0.03305918,0.029605703,-0.054094836,0.031178761,0.062706344,0.012787641,-0.02459099,0.056297053,-0.08109855,0.023461273,0.012213685,0.0686052,0.082038365,0.058285795,-0.0041521476,-0.094530545,-0.022963991,-0.07419807,0.09347213,0.09215448,0.002126068,0.06872796,-0.03675456,0.0498844,0.025462773,-0.022828963,0.046966925,-0.009989108,0.11685349,0.020943768,0.032190435,-0.06702523,0.0802533,-0.06254575,-0.025874238,0.0010882597,-0.017961055,-0.011688078,0.0027340713,-0.11857267,-0.042238884,-0.09200085,0.000101825215,-0.012901111,-0.015373136,0.0070595862,0.013930821,0.028801115,-0.022329058,-0.014161777,0.07486873,-4.2138968e-08,0.056475636,-0.034828804,-0.037997566,-0.026709402,0.018398518,-0.06865798,-0.0015795043,0.016460303,-0.042201295,0.029729916,0.019316759,0.0646637,-0.022998452,-0.05123897,0.07721566,-0.016191822,-0.0043676277,0.02625368,0.0026291811,-0.035126723,0.056539577,-0.05363926,-0.10192123,0.034817666,0.013415457,-0.09329753,-0.02098974,-0.034733165,-0.051610705,-0.03739486,0.014628076,0.057115078,0.042661134,-0.0011473908,0.0069997516,-0.022167828,-0.05443152,0.011531953,-0.014869283,0.011592679,-0.020435913,-0.059527084,-0.11024398,0.0032788902,0.05107105,0.02579411,0.017469784,0.05702097,0.035431232,0.10630553,0.014877686,0.0019090644,0.07212671,-0.044870753,-0.004395152,0.07956236,-0.04903096,-0.03190413,-0.066007406,-0.049097866,-0.045472957,-0.023111079,0.16580883,-0.07866969 +1.3.7.4,Catalyses the two-electron reduction of biliverdin IXalpha. Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum. The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm. Flavodoxins can be used instead of ferredoxin.,384,1.0,-0.024261376,0.015791118,-0.09494863,0.039010238,0.03610026,0.054143425,-0.01885859,0.016006164,0.031158714,-0.05284775,-0.00043090887,-0.040020518,-0.04739294,-0.020663997,-0.064297564,0.021229818,-0.075790085,0.09183037,-0.003255719,0.043893795,-0.027423536,-0.06501825,0.042463727,-0.025205012,0.005802902,0.046386536,-0.0040710135,0.021634463,0.025416322,-0.058058795,0.022916647,0.009188366,0.07387162,-0.036299534,-0.0354728,0.06587687,-0.015717879,-0.068024695,0.09733225,-0.025796523,0.010788707,0.05615472,-0.0013595074,-0.07987522,-0.08611072,-0.049846794,0.00068538846,-0.036057174,0.034493536,-0.015527902,-0.025660004,-0.035187535,-0.054171555,0.029116085,0.031447336,-0.045720305,-0.013841362,-0.014446116,0.044694964,0.07166991,0.030717919,-0.012604404,0.022667697,0.06673091,-0.033707254,-0.071438454,-0.031677216,-0.033575166,-0.023174908,-0.03485361,0.024198046,-0.005660297,-0.020619903,-0.04384971,-0.023947462,0.1375309,0.0203533,-0.021922437,-0.024381695,-0.029062107,-0.03822766,-0.03243296,0.03005368,0.119749784,0.009192041,0.0008523673,-0.09610361,-0.004544389,-0.05734272,0.04209556,0.09530858,0.12312343,0.08846077,0.004220712,-0.010120334,0.07646811,0.09341494,0.023048734,0.0126128625,0.004246479,-0.04124818,0.06946536,-0.05147057,-0.111877605,-0.0005267141,-0.028617142,0.005226781,0.009362776,0.042443816,-0.032348204,0.0007200994,-0.09710202,0.04225297,-0.019615266,-0.02345894,0.080106154,0.048777163,-0.030239273,0.029821135,0.050898734,0.002853755,0.004706032,0.017337587,0.004644895,-0.036848016,0.010682309,-0.06082677,7.9361606e-33,0.10252393,0.090660684,-0.043110684,0.0075458046,0.036754213,-0.017267352,-0.03244906,-0.058710758,0.025081666,-0.031563826,-0.06650338,-0.034234732,0.063431114,-0.07689495,-0.055018134,-0.07587732,-0.06614587,-0.031216297,0.09193782,-0.0060226284,0.09361672,-0.030147444,-0.047565483,0.06543149,0.04761406,0.01692108,-0.011948386,0.0012625743,0.0040927604,-0.015074414,0.06884814,-0.024352582,-0.11870244,-0.027752433,0.0051175286,-0.06492995,-0.013412987,-0.035578933,-0.12338034,0.04157037,-0.058942806,-0.029611923,-0.07945327,-0.07555135,0.15738969,-0.05126264,-0.098282404,0.10027459,0.026208047,0.10980039,0.03068506,-0.037193026,0.075391404,0.0031498182,-0.0936205,0.043623336,0.028480688,-0.016154753,0.09840015,0.055010993,0.029338015,0.07802184,0.045013472,-0.008519334,0.05799118,0.051106147,0.007703548,-0.072097205,-0.064074494,0.022154968,0.011216844,-0.033754006,-0.001462908,-0.009089764,0.08495331,-0.01176241,-0.09674371,-0.08417816,0.071172774,-0.0033319988,0.0086908955,0.05588895,0.04100791,-0.022666035,0.006582749,-0.044689544,-0.10145251,0.030316602,0.001861209,0.011073194,0.08394486,-0.033709478,-0.07389177,-0.037705895,-0.08274518,-6.7776514e-33,0.07644009,-0.057965644,0.0115156295,-0.015588673,-0.054943398,0.015573744,-0.0015620971,-0.02856186,0.018080669,0.018865641,0.09845534,-0.011735732,0.022772541,-0.022141894,-0.012217223,0.03669159,0.024867553,0.03116493,-0.0041474886,0.019894626,-0.05056296,0.0035491306,0.00761723,0.052071977,0.05148062,0.0001147541,0.014073902,-0.04294168,0.11937609,0.044252235,-0.0048621134,0.008274972,-0.058784112,-0.07101624,-0.0012844673,0.06493162,-0.035775248,0.005555606,0.057633974,0.003328008,0.002672437,-0.023192618,-0.008091319,0.035143334,0.043032423,0.019272106,-0.08416948,0.036513202,0.025463086,0.046615917,-0.053461917,0.014449482,-0.07076531,-0.012138332,0.021857886,0.014295541,0.07537555,0.008604898,-0.0045524756,-0.02839297,-0.014671439,-0.08250702,0.094374344,0.09526307,0.023423849,0.13727678,0.0003816187,0.10486948,-0.0034523418,-0.090360545,0.05378701,-0.044745516,0.07382583,0.009289372,0.013043678,0.026887726,0.083872825,0.01286664,-0.016682975,-0.003488748,0.0056414134,0.013191431,-0.0007744966,-0.0643588,-0.039139144,-0.10381913,-0.0355901,0.030015327,-0.00058642763,-0.051909402,-0.0116416775,-0.021723816,0.044777606,-0.019398533,0.049786914,-4.1605233e-08,-0.008485865,-0.020730084,0.07877699,-0.0061357035,0.039319806,-0.030691314,-0.055030793,-0.023079507,0.008472836,-0.03973591,0.006909199,0.08217823,-0.008053558,-0.0071492586,0.049747534,0.034211908,-0.0005007493,-0.00778531,0.012070908,0.0055451095,-0.07492418,-0.024263555,-0.09370638,0.042744894,0.0451408,-0.07228033,-0.040703025,-0.07017285,0.052342977,-0.028263664,0.035740346,0.08565689,0.017612249,-0.0076169805,-0.07925198,-0.048686918,-0.039740164,-0.06124593,-0.060649317,-0.008739471,-0.060946938,-0.027042098,-0.053076033,-0.06159692,-0.039826367,-0.011253696,0.017339615,0.05971623,0.0066241245,-0.009071716,0.04053854,-0.047470804,0.054703414,-0.04703688,-0.01939047,0.053341784,0.07429643,0.010158891,0.024545206,-0.03536495,-0.076718755,-0.019026453,0.15116185,-0.0032115623 +1.3.7.5,"Catalyses the four-electron reduction of biliverdin IXalpha (2-electron reduction at both the A and D rings). Reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Flavodoxins can be used instead of ferredoxin. The direct conversion of biliverdin IXalpha (BV) to (3Z)-phycocyanolbilin (PCB) in the cyanobacteria Synechocystis sp. PCC 6803, Anabaena sp. PCC7120 and Nostoc punctiforme is in contrast to the proposed pathways of PCB biosynthesis in the red alga Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as an intermediate [2] and in the green alga Mesotaenium caldariorum, in which PCB is an isolable intermediate.",384,1.0,-0.09642176,0.019050986,-0.08647131,-0.013171584,0.032134358,0.0473296,-0.028594013,-0.006095894,0.037595455,0.036253516,-0.031840414,-0.07163025,-0.059372306,-0.017482996,-0.04877379,0.044299636,-0.07810576,0.07838465,-0.02969427,0.09380606,0.05204233,0.010253182,0.0013847029,0.0017789555,0.001711081,0.0041418346,-0.037708763,0.021689493,-0.023523407,-0.039968554,0.008876278,-0.012739562,0.051244095,-0.07899617,0.02776645,0.04423491,-0.027099924,-0.09517934,0.06109848,-0.01336025,0.06369251,0.075211115,0.003992009,0.0005539496,-0.06856507,0.065472044,0.023361575,-0.013545633,0.03407718,-0.093733855,-0.016500369,0.012248912,-0.063953936,0.07714838,0.006428758,0.031245446,-0.08021632,-0.028512124,0.099507734,0.048299607,0.06431559,0.0023692504,-0.015982378,0.022412108,-0.02995323,-0.068735406,-0.020231048,-0.071318395,0.027306214,-0.012878228,-0.036582768,-0.0072614583,-0.021657156,0.0025441258,-0.01733516,0.14027092,0.084935464,-0.028077532,-0.045738634,-0.05862217,-0.03449569,-0.03128222,0.021974145,0.066582054,0.028477078,-0.069003284,-0.05944224,0.010627241,-0.06757993,0.044894125,0.099214755,0.1017133,0.1263801,-0.07530055,-0.002513828,0.044911183,0.12734032,0.021689832,0.043696124,0.030065825,0.0035922802,0.083042756,0.020335613,-0.13568257,-0.026988396,-0.029353347,-0.021623004,0.049203213,0.036880456,-0.009092725,-0.020223463,-0.048096478,0.0029326004,-0.03191743,-0.037229057,0.08800453,-0.010766562,-0.004509222,-0.03531916,0.01577583,-0.032020025,-0.05234329,0.041836265,-0.004071264,0.0035599782,-0.004045177,-0.10178232,6.743594e-33,0.059184242,0.022733241,-0.050065354,-0.037732977,0.04877014,-0.035984363,-0.033057705,-0.033700164,-0.014892533,-0.06981885,-0.06642829,-0.040963966,0.059810348,-0.044198398,-0.07931874,-0.012029718,-0.055286225,-0.07070497,0.052186508,0.057486746,0.061445467,-0.014900506,-0.024522085,0.051315695,0.0053930515,-0.024904896,-0.018053764,0.0115146255,-0.0060142307,-0.015715174,0.020647205,-0.0167075,-0.12426185,0.015113657,0.08181323,-0.06760967,-0.029242022,-0.072160035,-0.022956876,0.054165468,-0.09008775,-0.019014124,-0.05801334,0.014031296,0.08806937,0.037765384,-0.046981934,0.09014229,0.08115136,0.042533062,0.026229536,-0.029052895,0.060198996,-0.0128987655,-0.08085954,-0.02409283,0.0065627415,0.0129682645,0.06904229,0.02953911,0.045319196,0.059730947,0.029802632,0.05523013,0.050827637,0.042305738,-0.05079305,-0.051987562,-0.0030906731,-0.0691226,-0.02728731,-0.036471125,0.0909073,-0.011119166,0.104947634,0.008374082,-0.09454485,-0.08467423,0.0008425055,-0.011847046,0.016414784,0.03113347,0.039565008,-0.04241244,0.005569545,-0.04488063,-0.06528683,0.006873727,0.015809739,-0.033542085,0.06808725,-0.055914465,-0.05675511,0.011494195,-0.03351661,-5.6403767e-33,0.10389739,-0.016605213,-0.019472634,0.02704721,-0.031151503,0.030376382,0.0443585,-0.0736666,0.018505005,-0.042912405,0.15373611,-0.018811533,0.027845504,-0.022885418,-0.02110794,0.007763871,0.04537071,0.05765651,-0.036145315,-0.040920738,-0.031255733,-0.011151918,-0.044557143,0.0036359713,0.02313898,-0.020566538,-0.022231914,-0.05951676,0.047293637,0.05098652,-0.05289074,0.08341809,-0.081478715,-0.04961714,-0.031589087,0.020045746,-0.024382662,-0.027012035,0.03537684,0.06379685,0.05908529,-0.040322978,-0.035414588,0.02853685,0.070539795,-0.026250767,-0.027960362,0.08152095,0.021322777,0.079166494,0.036064357,0.033602897,0.009102067,0.0052521355,0.016676983,0.07210703,0.08036274,0.017143365,0.019866904,0.012269287,-0.025796784,-0.083283655,0.13197383,0.014661959,0.03651823,0.111316904,0.015566219,0.14263847,0.037325315,-0.075552754,0.040872224,0.00029684062,0.059631206,-0.025638139,0.015172435,0.0158695,0.070748314,-0.090831086,-0.056389622,-0.0027885814,0.019047095,0.013692968,0.052365422,-0.07440771,-0.013839097,-0.024638439,-0.005723339,0.010745177,-0.0810345,-0.049883865,0.011984123,-0.04940118,0.024339695,0.089742094,0.07571224,-4.561468e-08,0.048667952,0.037152577,-0.011514468,-0.00871736,0.07561326,0.0076541794,-0.019186236,0.037649117,0.005137699,-0.019899456,0.020923538,0.04222887,0.0053656246,-0.019324882,0.08446131,0.06638605,-0.024978567,-0.04224225,-0.0055647474,-0.005322153,0.010062032,-0.07806589,-0.12224862,0.032169737,-0.012193474,-0.107507996,0.010953284,0.005935676,0.017328626,-0.038142987,0.009685023,0.010561243,-0.03206346,-0.024112891,-0.0026637889,-0.010265364,-0.049062595,-0.06987362,-0.015265843,-0.004282644,-0.06937432,-0.013153128,-0.080733486,0.028287653,0.0047156885,-0.012218177,-0.047242235,0.058585763,-0.0070318044,0.01997461,0.061046034,0.0033358708,0.02260352,-0.048082795,-0.059268437,0.07436732,0.04552121,0.022991525,-0.1046129,0.025865601,-0.04781968,-0.010806913,0.11088165,-0.050468586 +1.3.99.1,A flavoprotein (FAD) containing iron-sulfur centres. A component of EC 1.3.5.1 succinate dehydrogenase (ubiquinone).,384,1.0,-0.05176843,-0.035496354,-0.13157365,0.049937617,0.111505814,0.050630014,-0.014088751,0.034045406,0.0185384,-0.09397553,0.028931998,0.004973676,-0.03435421,-0.07819327,-0.07677006,0.0023793392,-0.017678719,-0.012333096,-0.044303976,-0.029031593,-0.026166448,0.012580845,0.01596674,-0.03156392,0.011396906,0.045363158,0.035091527,-0.0019617928,-0.096091084,-0.021504372,0.10309179,-0.022232134,0.05247664,-0.028796557,-0.059748854,0.087776065,0.002586591,-0.03852117,-0.025144637,-0.0047965962,0.02272141,-0.0330925,-0.016929694,0.03128247,0.043560084,0.0085724555,-0.043687623,0.0840728,0.019849526,0.041205835,-0.038525544,-0.030935584,-0.04032234,0.07555727,0.010195652,0.040247783,-0.008055355,-0.022791687,-0.04217626,-0.0103842085,-0.008638155,-0.03499509,0.05274737,-0.016292913,0.040456872,-0.025396364,0.015332616,-0.05732396,0.05859766,-0.022140905,-0.016570352,-0.009138421,-0.07640606,0.04303698,-0.028542269,0.1240131,-0.07564474,-0.057208914,0.099942796,-0.03471519,0.08050493,-0.012203846,0.098303124,0.09620036,0.0510018,-0.04854756,0.045168165,-0.040225238,-0.055693522,0.07525057,0.013175374,-0.009904268,0.005696718,0.033109073,-0.0688755,0.06747146,0.049064673,0.07995296,-0.06256881,-0.037451435,-0.05397906,0.0367782,-0.011904578,-0.031612393,-0.07112146,-0.060733367,-0.026478846,0.091642596,-0.034759786,-0.028234374,-0.011736461,-0.10871465,-0.020800278,-0.08159232,0.018453494,0.022877868,0.07279884,-0.04623782,-0.05672718,-0.052307434,-0.0047645755,0.13525176,0.06182831,0.07950359,0.041475553,-0.017086953,-0.13599996,1.1844932e-35,0.085595116,0.0032622803,-0.010773567,-4.2198248e-05,-0.059510242,0.01321369,-0.11731471,0.050493762,-0.011512937,0.013426719,-0.051911507,0.028285963,0.054120325,-0.06676293,0.036339544,-0.03481489,-0.0021594248,-0.046006612,0.098250285,-0.08959573,-0.016604358,0.057146616,-0.0020072765,-0.012227914,-0.009331445,-0.0030882715,-0.055655137,0.032550544,-0.01593438,0.03171447,0.0025549699,-0.07944923,-0.0734105,-0.033130907,-0.005551729,0.020764625,-0.10395155,-0.062339734,-0.10187317,0.059182312,0.018023262,0.02492,0.017515628,-0.026623847,0.023581687,-0.037621364,-0.07544107,0.11693367,0.027672287,0.06475406,-0.0032730158,-0.0012913268,0.13578567,0.023348482,-0.07075909,0.019956533,-0.00598403,0.06274662,0.014365637,0.03186241,-0.02041799,0.061711825,-0.022812514,0.07447012,-0.045293625,-0.022514002,-0.05804989,0.0075839707,0.02704577,0.06447427,0.033774026,-0.0045518405,0.10439137,0.0036982147,-0.01020896,0.007091074,-0.041517314,-0.039186224,-0.04077332,0.038314205,-0.07694703,-0.053602293,-0.05132142,-0.0063925916,-0.04322703,0.09716589,-0.031938296,-0.009101191,0.0046583437,-0.015697932,-0.00047542425,-0.024675887,-0.010275251,-0.011140256,0.053649623,-3.6295868e-34,0.033537067,-0.07896145,0.0013792904,0.025946442,0.017665042,0.07319985,0.0472495,-0.03360413,-0.0063510616,0.023796445,0.08836347,-0.06435598,-0.0022064836,-0.058448236,0.06683061,0.05298192,-0.054254033,0.037108276,0.088848986,0.029246148,-0.009799376,0.017384905,0.030733941,0.073601454,0.039775424,-0.009825732,0.061943427,-0.06599594,0.04470165,0.043246724,-0.03605347,0.02848937,-0.042385966,-0.015595614,-0.07627364,-0.010138629,-0.016424531,0.007023896,0.037740514,0.034950737,-0.034631606,0.0053114477,0.0033955495,0.0976918,0.10812753,0.07359836,-0.04936143,0.08767816,0.023127854,-0.0066652335,0.017690435,-0.021666048,-0.037930585,0.06294709,0.041911304,0.0515244,0.0328833,0.063520476,0.0041395565,0.018742334,0.042477883,-0.060725726,0.03305493,-0.014386604,0.009865381,0.0702858,0.026206978,0.06580714,-0.030091712,-0.008463382,0.11518823,-0.05341063,0.013147529,0.025418956,0.042417686,-0.027494734,-0.0046507395,0.10352615,-0.028780272,0.06247612,0.016453682,-0.0044057183,-0.015538023,0.005030183,-0.0010158387,-0.112306975,0.0042813495,0.04052462,-0.037755586,0.032962214,-0.0921075,0.06171693,-0.06840773,-0.024112727,0.011918951,-2.6105171e-08,0.017670052,-0.048398893,0.037587073,-0.005441064,0.116426356,0.0028499772,-0.017714497,-0.01838528,-0.02702283,0.030744843,0.0006742539,0.08773371,-0.024680777,-0.025140896,0.05717114,-0.021937381,0.03301859,0.038368724,-0.011873277,0.006538143,-0.0705749,0.03207504,-0.07959773,-0.02659929,-0.02586385,-0.07036079,0.007390755,-0.07538251,0.048067685,-0.05004469,0.021101817,0.030008966,0.04096648,-0.09045674,-0.087386064,0.040847234,-0.0141443815,-0.05700793,-0.049321633,0.065358,-0.096131675,-0.014863999,0.0031062597,-0.00951912,0.0022107265,-0.010029952,0.036527388,0.04599963,-0.10341094,-0.023305576,-0.0052881045,-0.041295834,0.047389142,-0.030593373,-0.03806033,0.067198254,0.009703591,-0.13389516,0.0087334355,-0.0615818,0.0040062005,-0.013921832,0.08223356,-0.0012796568 +1.3.99.2,"A flavoprotein; forms, with another flavoprotein ('electron-transferring flavoproteins') and EC 1.5.5.1 electron-transferring-flavoprotein dehydrogenase, a system reducing ubiquinone and other acceptors.",384,0.99999994,-0.09102543,0.04736654,-0.05635912,0.05086027,0.07013026,0.017466908,0.031056816,-0.0033801536,0.0019654843,-0.082141645,0.033076305,-0.040107723,-0.044954453,-0.039302904,-0.059097443,0.021833083,-0.0624437,0.0018950537,-0.07560811,-0.015208429,-0.03683942,0.0023993675,0.0032392596,0.006950913,0.0060239267,-0.0030361263,0.026029546,0.0009371113,-0.04528933,-0.09295849,0.10789065,-0.0029199068,0.069521606,-0.061748933,-0.12579256,0.07751595,-0.011645059,-0.084369205,-0.02796934,0.031201553,0.057349402,-0.063593104,0.016947584,0.05257707,0.034312643,0.016282145,-0.047024574,0.10833888,0.026906524,0.032420143,-0.020140488,0.039543126,-0.068111256,0.06955234,0.03144399,0.047804125,-0.02806305,0.009464383,-0.055965725,0.020101277,0.015555634,0.020410573,0.0601803,0.043447543,0.014105768,-0.06293754,-0.019200591,-0.060931236,0.04019511,-0.023720488,-0.026667695,-0.037548818,-0.103811786,0.060136653,-0.019539285,0.063660555,-0.08906362,-0.002457478,0.07007731,-0.015655508,0.035096213,-0.058126368,0.0064523728,0.026753515,0.049894206,-0.013884258,-0.040368054,-0.060026307,-0.03350739,0.023710113,0.021479586,-0.06447893,0.052935258,0.04003184,-0.047039434,0.043004707,0.06775501,0.042277716,-0.055434555,0.010977787,-0.030118283,0.017595759,-0.045820016,-0.03448366,-0.073162094,-0.049947675,0.020874385,0.03977575,-0.034627765,-0.074775934,-0.008760754,-0.10461459,-0.03889875,-0.051024124,0.036583796,0.048854135,0.024646906,-0.04763305,-0.011642333,-0.0063186097,-0.0054803067,0.079944745,0.053838946,0.061705645,-0.008436171,-0.007196201,-0.10949729,2.7061052e-33,0.03490278,0.047972437,0.0032520054,0.020893207,-0.019573966,0.037086826,-0.05515377,0.018442588,-0.018800681,-0.07069176,-0.040077854,0.08587718,0.09008061,0.0032038852,0.034503616,-0.051710833,-0.0036819472,-0.014792559,0.10863258,-0.056088924,0.0012662988,0.036965087,-0.037973896,0.010203351,0.0148392925,0.030116653,-0.06675358,-0.004504382,-0.007192208,0.027922219,-0.055028677,-0.005755519,-0.08532339,-0.013124343,-0.04323482,0.025206592,-0.079611346,-0.06717718,-0.04102717,0.013851722,-0.034213185,0.022044662,-0.08821424,-0.032321073,0.047324963,-0.006464737,-0.043411776,0.10722565,0.0021066123,0.02869004,0.01881354,-0.04487596,0.12994628,-0.05076838,-0.06705953,0.036579583,0.0060446784,0.053107407,-0.036800988,0.02409057,-0.01603026,0.06945278,-0.03431497,0.019085178,-0.055069387,-0.014451192,-0.027602008,-0.07173721,-0.019324392,0.016188884,-0.007989298,0.04213405,0.09763809,0.021462088,0.039413735,-0.0071502905,-0.112731256,-0.021257626,-0.010304395,0.009615457,-0.11889724,-0.048985418,-0.017263358,-0.00944636,0.0052053523,0.06962981,0.00042729944,-0.00055268,0.006753514,-0.019150063,0.030811587,-0.039180484,-0.02361848,-0.002085131,0.09234151,-3.6412113e-33,0.0051460606,-0.06848791,-0.046713207,0.07050594,0.053766973,0.040407974,0.074510366,-0.07519937,0.0401388,0.030337466,0.06554915,-0.03879439,0.014814591,-0.08659189,0.038525764,-0.030090021,-0.05513381,0.053062633,0.061505716,0.0046304273,0.022762729,-0.0040090145,0.0063357307,0.05466212,0.020914232,-0.006511702,-0.01826138,-0.053026203,0.09082992,-0.008434281,-0.09665469,0.005763468,-0.040320873,-0.006722687,-0.01831439,0.038683128,-0.016785938,0.07262474,0.032214016,0.016376289,-0.009580321,0.016171776,0.022486202,0.047125008,0.08150674,0.13637315,-0.059860494,0.11688178,-0.0212208,-0.022296624,0.015703622,0.028417572,-0.09088807,0.08069206,0.014203048,0.094399065,0.07835895,0.01997506,0.028028864,0.00875212,-0.0579661,-0.068807065,0.0379986,0.037063293,0.014890249,0.041075125,0.044924114,0.11440601,-0.00809259,-0.049243137,0.13579036,-0.057833973,0.08193451,0.03357033,0.015479486,-0.018145509,-0.011954191,5.5042885e-05,0.0034380504,-0.00027052726,-0.0013542499,-0.045700897,0.0011528287,-0.014776894,-0.011064578,-0.086536154,-0.0022458371,-0.0015026797,0.002591522,0.072680004,-0.07683277,0.05123448,-0.048125435,-0.036705576,0.0007847298,-3.1522468e-08,0.057611205,-0.037613537,0.026114244,-0.011354086,0.13844122,0.045458004,-0.049995046,0.06939816,0.042905238,0.0088473065,0.030065387,0.084948145,0.04696838,0.00084186613,0.067984834,-0.022044191,0.08812523,0.020569269,0.004022487,-0.026100846,-0.049304787,-0.0045289714,-0.07944339,-0.054704517,-0.015675783,-0.085639104,0.031406075,-0.0072745895,0.07775184,-0.08596942,-0.0046805968,0.057115447,0.011969291,-0.015299409,-0.0906649,0.030046947,-0.02227404,-0.03612746,-0.024799185,0.092873745,-0.105169885,-0.029338233,-0.0406621,-0.024554633,0.06308712,0.014752778,0.050083008,-3.8322076e-05,-0.040956415,-0.018712573,-0.021065218,-0.024751928,0.03977163,-0.056485444,-0.06056311,0.036000744,-0.055321928,-0.07302518,0.04066996,-0.14026661,-0.020976571,0.030213557,0.13707192,0.042436462 +1.3.99.3,"A flavoprotein; forms, with another flavoprotein ('electron-transferring flavoprotein') and EC 1.5.5.1 electron-transferring-flavoprotein dehydrogenase, a system reducing ubiquinone and other acceptors. ",384,1.0,-0.08740809,0.0492413,-0.057269994,0.050197117,0.067863256,0.021437258,0.034049537,-0.0034892797,0.0049901255,-0.08314977,0.03439949,-0.041723102,-0.04178938,-0.040652487,-0.053488355,0.021560362,-0.06448817,-0.0011099176,-0.07702324,-0.014486395,-0.0357244,0.0028334726,0.0031342886,0.0043725395,0.0051675485,-0.0023352143,0.026417077,0.0012226104,-0.046033878,-0.08914088,0.10639471,-0.0029312933,0.069710284,-0.06332355,-0.12698701,0.075599276,-0.012503795,-0.081254706,-0.02874632,0.03208173,0.058092877,-0.0647065,0.01700744,0.054659072,0.03661723,0.01959138,-0.0439765,0.10575729,0.027165275,0.033289224,-0.016756868,0.04072927,-0.06605301,0.07074491,0.030730695,0.05034676,-0.028548503,0.009573627,-0.055795263,0.017773462,0.015298837,0.020906752,0.06199191,0.04352883,0.014895414,-0.06499489,-0.01873832,-0.06131109,0.03660284,-0.024055237,-0.02723034,-0.041148905,-0.10204174,0.05588514,-0.017652703,0.06583515,-0.08846047,-0.003208188,0.06882071,-0.013891349,0.034826443,-0.057167556,0.005284316,0.026054204,0.04956468,-0.01203275,-0.037389874,-0.067625746,-0.035070285,0.024730219,0.023398357,-0.06565561,0.049657967,0.040615663,-0.04433111,0.040904436,0.06932503,0.04398,-0.05394286,0.012484372,-0.029385054,0.018112909,-0.048698142,-0.03789812,-0.06923397,-0.04871338,0.020702997,0.042936444,-0.034523323,-0.074682035,-0.010331423,-0.10639605,-0.038515877,-0.05192686,0.037509758,0.052158523,0.022156248,-0.049021382,-0.010469851,-0.0050460873,-0.0050783153,0.07863314,0.053278986,0.06577648,-0.008142818,-0.008433297,-0.10888542,2.5438609e-33,0.03668323,0.047434136,0.0044976124,0.017977819,-0.01827105,0.03726195,-0.05518478,0.017019415,-0.021820296,-0.07334784,-0.039495975,0.08587238,0.091882035,0.0053268666,0.033452984,-0.049097523,-0.005463921,-0.016161213,0.10803664,-0.05746941,0.0021083038,0.03354761,-0.037261836,0.008850396,0.011491709,0.031432472,-0.06638521,-0.00394129,-0.007687052,0.028753147,-0.05321347,-0.0068281107,-0.08663497,-0.011290596,-0.043250475,0.022736825,-0.07877864,-0.06510374,-0.039870605,0.012691075,-0.033823878,0.02127887,-0.08776935,-0.029799938,0.047311902,-0.00813634,-0.03936336,0.10419536,0.0033532858,0.026548907,0.019614337,-0.045162767,0.13135378,-0.051207,-0.06548377,0.038956307,0.0056990995,0.05422319,-0.038576365,0.021925928,-0.019155538,0.07110563,-0.031914566,0.021269556,-0.05484116,-0.015849806,-0.027700609,-0.071600914,-0.019285219,0.013040928,-0.0036587142,0.042144664,0.09815058,0.020806756,0.04089364,-0.006762188,-0.11375701,-0.020875039,-0.0098795565,0.0069358177,-0.11879968,-0.04814126,-0.01756505,-0.009334468,0.0048626647,0.06788934,-0.0004916212,0.0020910322,0.007230131,-0.016287904,0.032641657,-0.036907844,-0.027367234,-0.005361042,0.09480787,-3.3932327e-33,0.0057643717,-0.06418643,-0.05037634,0.0677398,0.054056756,0.039094694,0.07683081,-0.07429413,0.041120104,0.03223143,0.066965476,-0.03495895,0.013772679,-0.08734688,0.039121814,-0.031401966,-0.055325408,0.05490038,0.061712507,0.002041015,0.024500707,-0.005120737,0.0059626987,0.050786648,0.021194985,-0.0053440277,-0.01886336,-0.052208323,0.0896757,-0.008880298,-0.09613447,0.0067072357,-0.04208457,0.00067067344,-0.019389171,0.03876122,-0.01938336,0.07608218,0.032850444,0.01400816,-0.01058858,0.013889856,0.024239011,0.04762781,0.08418061,0.13642596,-0.059089083,0.11936516,-0.022398751,-0.02114358,0.016786417,0.029850682,-0.09233959,0.07808362,0.013799751,0.09982323,0.07796465,0.020142626,0.02816572,0.0066951197,-0.05544604,-0.06854312,0.0402507,0.03483175,0.0118379835,0.040646993,0.04712286,0.11207854,-0.007910461,-0.04903493,0.13411584,-0.05633739,0.07804193,0.033034995,0.015213905,-0.019514792,-0.011911312,0.0012482146,0.0027094549,-4.7241763e-05,-0.0029575713,-0.04652249,0.0039058414,-0.01619366,-0.013370552,-0.08269179,-0.005806476,-0.00017334048,0.0036645061,0.072698124,-0.075505644,0.049843825,-0.04825301,-0.04018589,0.0021982894,-3.1327602e-08,0.057235897,-0.037867144,0.027070392,-0.011968167,0.13836455,0.04159892,-0.049778476,0.0660081,0.043066695,0.00617897,0.029374316,0.08645086,0.049442578,0.0014571445,0.06898534,-0.022997113,0.09490167,0.019723797,0.0037440686,-0.028716527,-0.050922893,-0.0050864536,-0.080811456,-0.051028144,-0.012815699,-0.0842579,0.031785898,-0.0033312372,0.07694212,-0.088087395,-0.0027699738,0.055569783,0.0078089237,-0.013523748,-0.094091974,0.028749034,-0.022465441,-0.03814962,-0.023284985,0.088611044,-0.10522151,-0.031119628,-0.037147257,-0.024103036,0.06433602,0.018710474,0.05074719,0.00037003198,-0.039582986,-0.019176954,-0.023711002,-0.02737791,0.040393468,-0.05773871,-0.06250533,0.03737346,-0.05396134,-0.074909925,0.04274249,-0.13954009,-0.021610076,0.031029345,0.13742703,0.03944972 +1.3.99.5,"A flavoprotein. This bacterial enzyme, characterized from Comamonas testosteroni, is involved in androsterone degradation. cf. EC 1.3.1.22, 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+).",384,1.0,-0.07986925,0.010345426,-0.09195663,0.017149735,0.08972641,0.037338607,-0.08839886,0.07403731,0.029054608,-0.059337627,-0.007824202,-0.012385392,-0.09370709,0.032162,-0.1029601,0.058843814,-0.035341877,0.0011579191,-0.013498543,-0.004949793,0.026331702,0.044702873,-0.0005305548,-0.0075686425,0.04104658,0.033228006,0.020213602,0.0122234365,-0.07560295,-0.024679456,0.015149329,0.039464124,0.0899716,-0.055803154,0.017154245,0.08783761,0.023663202,-0.07420132,0.0927506,0.05018463,0.04933188,0.017600996,-0.033304885,0.018718941,0.06318182,0.007981551,-0.029762486,0.09732592,0.02450527,0.0046320143,-0.07200593,0.0018192276,-0.019164767,0.04485099,-0.003100761,-0.02356239,0.024298564,-0.07289127,-0.088723674,0.016708206,0.035593916,-0.026578313,0.05055446,0.062957734,0.032088008,-0.056325264,0.041722264,-0.04592478,-0.00035388695,0.0025963422,-0.08016391,-0.043405082,-0.018963493,0.11938514,-0.05967911,0.07875956,-0.008017389,-0.04919808,0.083542734,-0.02360248,0.075534195,-0.037849944,-0.0008336672,0.0732866,0.04932074,-0.057837684,-0.021378186,-0.016821763,0.03040455,0.07450019,-0.03510187,0.020323975,0.012342684,-0.020274714,-0.08179865,0.036579505,0.016074972,-0.040248424,-0.04773118,-0.037337497,-0.045104425,-0.0021738694,0.0061445734,-0.047394365,-0.06866815,0.018425323,0.0078385305,0.023676878,0.02489444,-0.016203957,0.019101415,-0.074678496,0.01912073,-0.06703362,0.05853586,0.070136905,0.015941495,0.0017445189,-0.08273344,0.014740776,-0.002044228,-0.028051523,0.0044677006,0.049284764,-0.0141674075,0.015466488,-0.11399429,6.4486477e-34,0.10630052,0.0036112822,-0.053903483,0.019355178,0.029137906,0.005013866,-0.00076826353,0.033739697,-0.056804113,-0.07403293,-0.01618395,-0.05555499,0.0269304,-0.028117357,0.048060756,0.024581358,-0.014187934,0.005375356,0.056823798,-0.03966309,0.0034410467,0.07272315,-0.037352942,0.0074293097,0.079056665,0.048717823,-0.03880579,-0.044764843,-0.027749443,0.0017417606,0.0127134165,-0.071583,-0.13527806,-0.029608455,0.077409945,-0.016116243,-0.051995024,-0.051874813,-0.07889184,0.07430433,-0.07737795,0.01233799,-0.033116855,0.013269552,0.010080571,-0.053244576,-0.07296861,0.100649774,0.052424364,0.03910119,0.013434133,-0.045053728,0.10915029,0.010280545,-0.07941708,0.066438936,-0.02326548,0.014769585,0.0009836298,0.02460428,0.014195581,0.054609403,-0.06832941,0.0427504,-0.051692046,-0.007806315,-0.05245434,-0.101649545,0.056888532,0.07884132,0.009292067,0.010439389,0.05892191,0.04659864,-0.018838586,-0.0059685595,-0.06683616,0.013226544,0.0011535272,-0.015602945,-0.014511996,-0.06218901,0.016746359,-0.018573252,-0.047652505,0.106136374,0.041698534,-0.0025609245,0.016870692,0.020321934,0.08744644,-0.06063649,0.0016171664,-0.034302574,0.046509176,-1.1820056e-33,0.06012911,-0.10065971,-0.013003073,-0.01718162,-0.04966289,0.066171534,-0.034218334,-0.01999772,-0.04729779,-0.049882665,0.027416026,-0.058558702,0.0063648266,-0.03932534,0.062041096,0.015253587,-0.043941136,0.04986441,-0.039895944,-0.041003514,0.056211054,0.05054551,0.044648338,0.024046758,0.010128697,-0.002208886,-0.018108413,-0.0024161658,0.03856023,0.05028211,-0.052223314,0.06405318,-0.047633532,-0.053950083,0.015566259,0.089901745,-0.0459119,-0.00023000722,-0.0071038445,0.036951613,0.014177523,0.05866478,0.013918621,0.056498356,0.03625725,0.049805317,-0.0641189,0.054002557,0.088645965,-0.04451812,0.007971201,0.0021391038,-0.049816076,0.07342867,0.011141361,0.015994793,0.008541014,0.025820449,-0.04057066,-0.012016977,-0.025642196,-0.11134835,0.038784884,0.024742171,0.10509147,0.10585385,0.05230309,0.057201397,0.021213364,-0.020202046,0.10977255,-0.043622743,0.0406608,0.081190094,-0.0099810865,-0.021874567,-0.09555026,0.031847112,-0.00069164863,0.045479972,0.00012502883,-0.02066091,-0.0029960135,-0.0012245738,-0.048270196,-0.12591252,0.02693232,0.09258151,-0.0043596183,0.018074626,0.014930619,0.00048439944,-0.0871555,-0.03742791,-0.022308772,-3.4675722e-08,0.057880297,-0.054908533,0.028524904,-0.012330972,0.06288712,-0.00102748,0.039796393,-0.0127294,0.10874605,-0.04051628,-0.0045553707,0.12493968,0.023590999,-0.013842922,0.07022365,-0.056614462,-0.019083701,0.030422235,-0.009258416,-0.025651233,-0.06542766,-0.038086623,-0.11489753,0.04037953,-0.018626848,-0.008288802,-0.013174807,0.0017366542,0.123031296,-0.03141661,-0.011143434,0.034364544,0.0725359,-0.03994586,-0.09952561,0.035114497,-0.05084384,-0.049662374,-0.04570741,0.07864888,-0.09862289,-0.024762783,-0.04615381,-0.0016113515,0.035370596,-0.0086271,0.073375255,-0.001085171,-0.058119338,-0.07953782,-0.018638767,-0.019991918,-0.0017532853,0.015354314,-0.104117155,-0.028455023,0.005182128,-0.0391438,-0.03810749,-0.07141132,-0.0011046976,0.004493197,0.17881803,-0.012951397 +1.3.99.7,A flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.3.99.8,"A copper protein. The oxygen atom of the -OH produced is derived from water, not O2; the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH2- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH2-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors.",384,1.0,-0.097253546,-0.038795903,-0.014227542,0.06103318,0.15758882,-0.013215446,0.001049763,0.014340777,0.017583936,-0.038706955,0.069404274,-0.054793354,-0.07666912,-0.023809472,-0.08686749,0.07803241,-0.04915931,0.00642624,-0.05547556,-0.0015421252,0.041859306,0.052070647,0.0008422231,-0.00728182,-0.031590786,0.09475866,-0.001776376,0.00110877,0.0796691,-0.038228244,-0.028954921,-0.04643888,0.04939505,-0.033748437,0.005989934,-0.040436525,0.040255994,-0.039874975,-0.03633079,0.00081244565,0.060198143,0.0049721035,0.04512119,0.025932826,0.0012782774,-0.065199435,0.10112471,0.024833336,-0.02984176,-0.01851286,-0.041529886,-0.041053455,-0.07396008,0.053844783,0.0026193499,0.077509776,-0.036685526,-0.07376509,-0.008607098,-0.067781016,0.009470186,-0.033380993,-0.006551126,0.045456078,0.039318305,-0.0010433046,-0.0032588614,-0.0355219,-0.041790236,-0.052167006,-0.007467384,-0.04071026,0.041074503,0.018584017,-0.011976894,0.08152275,0.099761434,-0.05491751,0.07446519,0.0047075343,-0.033000145,0.03785181,-0.004867501,0.093382604,0.07713047,0.025418978,0.0045790737,-0.010831017,-0.06538891,-0.06689437,-0.043081343,0.029313846,-0.022485347,-0.07580654,-0.052549962,0.06314032,0.1104046,0.0013693841,0.015793046,-0.018461358,-0.00426839,0.092920154,0.012703492,-0.11719475,-0.01934889,-0.0042872066,-0.040484533,0.090093486,0.07867091,0.036832362,0.028036881,-0.05777167,0.015692001,0.019951621,0.070060566,0.026446136,-0.006173437,-0.040328264,-0.07427921,-0.0405298,0.0015068693,-0.051762152,-0.018144669,0.017623916,-0.04649112,-0.021094885,-0.06657995,2.8324473e-33,0.06593597,-0.005617122,0.0068187434,0.028354254,0.06311829,-0.04660305,-0.08222406,-0.029360576,0.027664993,0.045183774,-0.060975883,-0.026662905,0.049887467,0.012246568,0.01775471,-0.040638417,-0.055493783,-0.017404199,0.064594135,0.040611215,0.024164993,0.09341929,-0.031180765,-0.0032435698,0.06514811,-0.05056966,-0.01744966,-0.064580455,0.006497672,-0.026143322,0.048909105,-0.034286544,-0.042847004,-0.024467094,0.032606296,-0.08995693,0.022171048,0.0069393516,0.025253525,0.055983257,0.010329359,0.0129638575,-0.07399743,0.0116330655,0.06815802,-0.08886805,-0.050448455,0.1110141,0.04313622,0.028815381,-0.006241345,-0.075458676,0.08012839,-0.007455635,-0.08603362,-0.07138507,-0.07617917,0.05015388,0.041915666,0.047893573,0.0019641686,0.07896481,-0.04205961,0.031768117,-0.0593873,-0.018094415,-0.055856913,-0.04148805,0.05447492,0.01185203,-0.06701862,0.038685575,-0.011070228,-0.02434294,0.031375956,-0.07609356,-0.058559816,-0.025399618,0.08640516,0.07415515,-0.025218448,-0.018907964,0.016732987,-0.008702294,-0.03983459,0.01913107,-0.04799638,0.025537513,-0.009552145,-0.043191288,0.11344004,-0.061673265,-0.012907687,-0.08626549,-0.007345689,-2.8813273e-33,0.06323023,-0.087739654,-0.0020059166,-0.0310253,0.039770547,-0.026027288,-0.043506864,-0.0128255,0.09935333,-0.061768107,0.111558065,0.054458536,0.033697072,-0.035997372,0.052956644,0.0133487545,-0.09653866,0.12915792,0.020692635,0.011460954,-0.016948914,0.00024137416,-0.016821334,-0.009635634,0.056270733,0.092243955,-0.07282768,-0.013485802,0.092741996,0.07923053,-0.04320235,0.069239765,-0.024195395,0.009477703,-0.006790937,0.04881784,-0.034242626,0.006039992,-0.0021040505,0.08804239,0.05016481,-0.008936695,0.039588798,0.06470535,-0.0014198847,0.029090673,-0.103714034,-0.01756592,-0.06584501,-0.015099987,0.11292546,0.0132808145,-0.035209067,0.03855839,0.056049228,0.054388452,0.00812564,-0.02347331,-0.022522215,0.03499109,-0.04682247,-0.05841494,0.0064688954,0.054943893,-0.024297412,0.047760963,-0.046374172,0.11358218,-0.036292907,-0.0567446,0.03785298,0.048390362,0.010753568,-0.018155113,0.026114324,-0.030571345,-0.031859998,-0.0050669005,-0.018142473,0.04643539,-0.05765706,0.048894126,0.023753705,-0.05149726,-0.0124066835,-0.031874064,-0.031148812,0.065634295,0.00991227,-0.005548901,-0.03819692,-0.052899536,-0.054426905,0.119732805,0.061016485,-5.005682e-08,-0.032948293,-0.06040794,0.0937262,-0.0052408855,0.002362276,0.102220245,0.09292397,0.0012462419,0.05450651,0.01630378,0.009077393,0.090718426,-0.015824793,-0.09203626,0.0372915,0.037084263,-0.040532853,-0.036930107,-0.020496031,-0.051581156,-0.033055633,-0.04805258,-0.04108356,0.05527031,-0.020917209,-0.039417047,0.025596716,0.013708129,-0.056073178,-0.017374182,0.02279653,-0.012307148,-0.008142417,-0.009477968,-0.043399677,-0.024110833,0.035164572,-0.017005485,-0.06349772,-0.0072222077,-0.065629035,-0.0037229452,-0.10235209,-0.034658916,0.085937545,-0.013246827,-0.04274716,0.048570663,0.010227419,-0.06015749,0.017850835,-0.03303667,0.007125121,-0.046593495,-0.083692886,-0.010485778,-0.008888104,0.017610721,-0.06548366,0.015036356,0.0063887783,0.04895318,0.19762994,0.027317885 +1.3.99.10,"A flavoprotein; forms with electron-transferring flavoprotein and EC 1.5.5.1 (electron-transferring-flavoprotein dehydrogenase) a system reducing ubiquinone. n-Pentanoate can act as donor. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.99.3 (acyl-CoA dehydrogenase) or EC 1.3.99.12 (2-methylacyl-CoA dehydrogenase).",384,1.0,-0.09786486,0.038725246,-0.07508157,-0.0067329938,0.065206185,0.0065227114,0.005668042,0.015116685,0.015061042,-0.11725154,0.04299391,-0.06704788,-0.056693017,-0.016328903,-0.07511998,0.009886966,-0.05828915,-0.011257286,-0.04823079,0.009264422,0.0051809237,0.018294903,0.011407101,-0.04228815,0.046056304,-0.028084068,0.019820362,-0.0023265758,-0.015637223,-0.091398664,0.05652289,-0.020297239,0.032625977,-0.096335545,-0.08541409,0.10124342,-0.019170938,-0.032350767,-0.035017647,0.09235888,0.05716234,-0.075284265,0.003180503,0.053380482,0.04353381,0.0058026123,-0.028066952,0.114760615,0.0079795765,0.041081764,-0.05317071,0.006624579,-0.046744827,0.1026994,0.052989792,0.017398931,-0.010965417,-0.015466132,-0.08179457,-0.019120375,0.054302275,0.043118212,0.059439577,0.015869372,0.04399172,-0.050739534,0.02443032,-0.0728876,0.08045333,-0.053259205,-0.011382038,-0.031959828,-0.10431731,0.043183163,-0.02743953,0.087226115,-0.109124064,0.020692494,0.023268247,-0.016875582,0.05102855,-0.011239218,0.009931181,0.017436547,0.066633336,-0.026800225,-0.04106438,-0.06438362,-0.018088764,0.049023367,-0.028421061,0.004070466,0.028671885,0.023542253,-0.09885761,0.043878485,0.06717942,0.06787443,-0.061718147,0.018731553,-0.0065796087,0.042259052,-0.07330108,-0.044926517,-0.057762556,-0.027783196,0.013731669,-0.009006924,-0.010699948,-0.051112726,-0.034814175,-0.08171157,-0.03069083,-0.032632947,-0.003020276,0.032680552,-0.03816349,-0.04186921,-0.012767467,0.020023013,-0.0110337855,0.08803479,0.042287473,0.058703437,0.020374307,0.040703814,-0.11605477,2.4161903e-33,0.039125517,0.032598335,0.012680954,0.0011032269,-0.011317377,-0.006234328,-0.069431156,0.010893942,-0.054824647,-0.08832532,-0.03014701,0.0636536,0.08870219,0.043033592,0.015633987,-0.05260145,0.008404111,-0.008810503,0.11159411,-0.048127305,0.026436986,0.0571719,-0.06437818,-0.0017189521,0.034212966,-0.014834703,-0.059749912,0.016225053,0.006271867,0.022227999,-0.0404162,-0.040295277,-0.064084664,-0.05507464,-0.02574785,-0.025147416,-0.05262213,-0.08645326,-0.07746988,0.02693997,-0.03268113,0.039488055,-0.049142238,0.0055477056,0.08173277,-0.0042784517,-0.037305616,0.07408209,-0.0050514373,0.023418033,0.00970295,-0.032253493,0.100761496,-0.053074073,-0.064350575,0.0019991798,-0.0158936,0.054186728,-0.024518928,0.018546518,-0.0062655504,0.086773776,-0.032156855,-0.011525647,-0.06162957,-0.012710475,-0.043618254,-0.07967556,-0.010476711,-0.008487057,-0.0038375885,0.016756168,0.06435627,0.04744103,0.038388498,-0.02110575,-0.08768576,-0.026869508,0.011625306,-0.020617608,-0.109243505,-0.03327471,-0.0017764285,-0.058132615,-0.03754698,0.036769193,0.01605235,-0.01777673,0.03662931,-0.048327833,0.04829823,-0.006916426,-0.07405381,-0.06436685,0.12117321,-2.7930749e-33,0.022601068,-0.057261556,-0.050650258,0.06465284,0.036434196,0.05492862,0.061848868,-0.044974808,0.06317073,0.0062249852,0.041721307,-0.03603786,0.04338618,-0.07108556,0.046841495,-0.018559977,-0.051310357,0.076732665,0.067637235,-0.005390233,0.0032411518,0.033356804,0.0028002982,0.061528794,0.0013859883,0.007383717,-0.03821058,-0.046505753,0.073165976,0.002063941,-0.039031077,0.015751561,-0.07125012,0.053217996,-0.035347175,0.08350046,0.02381486,0.04976164,0.0020091527,0.040268037,-0.022876259,-0.042486824,0.028370392,0.03817944,0.04054651,0.088522464,-0.06648721,0.07667188,0.013413126,-0.020207256,0.039460775,0.05659684,-0.0434465,0.056602202,0.039528277,0.07731272,0.09623514,0.0052058944,0.04135152,-0.012089809,-0.007029768,-0.056867823,0.039858956,0.046827458,0.014127636,0.03697671,0.04720149,0.123189054,0.005624358,-0.03795265,0.100518495,-0.014160421,0.08223814,0.006947962,0.0022596328,-0.004532098,0.0027244887,-0.008906941,-0.016334143,-0.041478526,-0.008985005,-0.0741154,0.025406439,-0.011904019,-0.032405104,-0.06640618,0.0413404,0.015810344,-0.0017285667,0.07421143,-0.047987826,0.029608073,-0.07078024,0.021850033,0.063715465,-4.021821e-08,0.07316516,-0.029486714,0.024792643,0.006999534,0.10480068,-0.021853903,-0.040363126,0.045384116,0.059486724,0.020162307,0.0057268334,0.09360299,0.06662021,0.035012566,0.066289455,-0.0023839378,0.11426969,0.022906711,-0.0066693886,-0.003273485,-0.06603807,0.019686263,-0.10201158,-0.0611165,-0.016834075,-0.065523334,0.067098744,0.034614284,0.061871067,-0.0649144,0.013684347,0.052051302,-0.0061925226,-0.016735874,-0.07973833,0.027875226,-0.020564305,-0.04265241,-0.043641046,0.06287002,-0.104292154,-0.05447148,-0.064297386,-0.006086055,0.093448676,0.0027171485,0.031599827,0.009775139,-0.060147736,-0.02122089,0.0046788612,-0.030301679,0.061764903,-0.033772692,-0.05215329,0.042074956,-0.058520302,-0.04158627,0.07211252,-0.11609279,-0.022237722,0.013459944,0.19506116,0.029893743 +1.3.99.11,"An iron-zinc protein. Oxygen can act as acceptor, but much more slowly than 2,6-dichloroindophenol or 1,10-phenanthroline.",384,0.99999994,-0.074144095,-0.05142883,-0.030582998,0.07621199,0.13750692,-0.043410193,0.09495366,0.04161548,0.06852258,-0.016163256,0.011873322,0.02326513,-0.06516725,0.033827867,0.0029619408,0.08272593,-0.004916156,0.047211114,-0.086264625,0.04503488,-0.029766772,0.038128026,0.007142752,-0.070449054,-0.054994617,0.02937422,-0.0051938426,0.0044462592,0.032335922,-0.048755243,-0.021495894,-0.019617558,0.043348268,0.03114355,-0.058599472,0.036693282,-0.025604824,-0.07404525,-0.059407074,0.01358083,0.012072483,0.058540348,0.008361361,-0.028885452,-0.03705513,-0.05424013,0.018501377,0.019257484,0.025086433,0.013434798,-0.036611125,0.02611826,-0.094489746,0.080907434,-0.046372913,0.052816913,-0.0975162,-0.015270221,-0.024498736,-0.047986988,-0.045678735,-0.04576464,0.0071006627,-0.016638367,0.02725622,-0.029425304,-0.0055271294,-0.024424748,-0.025147842,-0.061401524,0.033188898,-0.0043548625,-0.02503809,-0.008060582,-0.0306726,0.07205789,0.02854206,-0.060107786,0.101828426,0.0065263137,-0.026058652,-0.014117089,0.043068543,0.10911228,0.07446649,0.026471576,-0.058247283,0.023999915,-0.09895291,0.07118143,-0.033795692,0.072085276,0.011984606,-0.040251307,-0.029541861,0.030262647,0.06154421,0.017517382,-0.037433434,0.04029757,-0.004027302,0.09263286,-0.030121863,-0.07173982,-0.028943809,-0.005599329,0.008859088,0.026590968,-0.0063772593,0.0041084476,0.016962355,-0.10095677,0.098761745,-0.013004857,0.0047589033,0.030442003,0.030538216,-0.013850621,-0.039284267,-0.015160992,-0.0017333127,0.03556505,0.004889568,-0.0425283,-0.056687396,0.02767149,-0.04806723,2.4153013e-33,0.016066883,0.021238696,0.044482317,0.066798635,-0.0881063,0.04147545,-0.07053051,0.03657646,0.0087971445,-0.06915549,-0.08024065,-0.053744745,0.053656023,0.047454957,-0.02158834,-0.10845446,0.0081073595,0.012799388,0.09449665,-0.02528796,0.03988484,0.05893839,-0.02992163,-0.03588575,0.037395187,-0.009941366,-0.06416906,-0.019533422,-0.033442855,-0.031815078,0.046030905,-0.056371167,-0.03160575,0.023428677,0.030333966,-0.0175451,0.034094047,-0.033605307,-0.02396426,-0.11293089,-0.04383035,-0.024201991,-0.13418916,0.049496416,0.08414522,-0.046285152,-0.017451327,-0.0036288712,-0.05110736,0.012101728,-0.014464076,0.024657698,0.03253303,-0.05972285,-0.07769379,-0.03893083,0.014624765,0.031834163,-0.00088859635,0.066203505,-0.023809997,0.10018742,-0.05537572,0.07717268,0.044477448,0.012262618,-0.08013347,-0.046479095,-0.012583476,0.07068202,-0.014631982,-0.014528946,0.012408405,-0.0031277053,0.032014396,-0.06430714,-0.008397536,-0.026476346,0.050676897,-0.0048988247,-0.012092647,-0.06829045,-0.041341588,0.029409453,-0.13347323,0.017444557,0.017858254,-0.05523093,0.053091217,-0.04250346,0.056709237,-0.0938702,-0.06952435,-0.07173871,0.043467373,-3.0415145e-33,0.05030657,-0.113064796,0.02028769,0.09244831,0.0666264,0.063784376,-0.0239793,-0.045980092,0.037516676,-0.03306708,0.12389402,-0.010794509,0.107706785,-0.04482613,0.05222335,0.08611514,-0.079523265,0.07859969,0.072166584,0.029661102,-0.03622588,0.02921165,0.020819627,0.07993413,0.015822843,0.07169769,-0.041194927,-0.096310705,0.08959609,0.06850791,-0.06252779,0.041341893,0.047184367,-0.07690082,-0.02202877,0.021219485,-0.02999495,-0.06861312,-0.07887507,0.02070788,-0.021154445,-0.049206793,0.036581658,0.061407004,0.033772837,0.020900311,-0.022184549,-0.017197335,-0.052831326,0.027557548,0.05809406,0.0544202,-0.086233936,0.022922553,0.1259231,0.015781967,0.02061696,-0.054773297,0.0152728455,0.044825107,0.00037656183,-0.056075595,0.057097383,0.059953615,0.033513095,0.038820695,0.039609097,0.10007449,-0.0013611829,-0.03406429,0.13022767,0.041912608,0.12768953,0.011275946,0.08496967,-0.018633047,0.05353883,0.010739807,-0.04283213,0.037365362,-0.10219818,0.050454047,0.01740834,-0.026780253,0.024407817,-0.04619699,-0.017350432,-0.027042942,-0.0663347,0.04437784,-0.053716056,-0.019888248,-0.0047072694,0.046432707,-0.010835732,-3.658434e-08,-0.035309184,-0.06150587,0.07360157,-0.08172206,-0.0419345,0.033941887,0.0865513,-0.040444996,-0.050396323,0.0096754525,0.050806034,0.08595315,0.05388837,-0.05107746,0.075986825,-0.0006531179,-0.038172767,-0.025841456,-0.01677466,0.012100255,-0.02107421,0.034470055,-0.012674774,-0.03201473,0.0078214295,-0.06324206,-0.039935194,-0.00037693887,0.036193334,-0.011412461,0.012647239,-0.007160955,0.0011602066,-0.05638925,-0.030098872,0.01835404,0.021541653,-0.07571103,-0.11153514,0.03369638,-0.05258796,-0.0012455102,-0.07448158,-0.0010848666,0.015443877,-0.017734114,-0.008743646,-0.0014497297,-0.035067875,-0.006395051,0.02496834,-0.042252783,0.01952096,-0.04592182,-0.056391157,0.049544305,-0.011228783,-0.017969415,-0.023689043,-0.03709305,-0.04257986,0.0058657075,0.12572522,-0.011953124 +1.3.99.12,"Also oxidizes 2-methylpropanoyl-CoA. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.8.7 (medium-chain acyl-CoA dehydrogenase), EC 1.3.8.8 (long-chain acyl-CoA dehydrogenase), EC 1.3.8.9 (very-long-chain acyl-CoA dehydrogenase) or EC 1.3.99.10 (isovaleryl-CoA dehydrogenase).",384,0.99999994,-0.08535285,-0.06975008,-0.01567512,-0.022549184,0.116869286,-0.02989496,-0.16638222,0.009661291,0.016253162,-0.08910723,0.079024576,-0.057405144,-0.055631474,-0.021981202,-0.02699982,-0.0011533962,-0.016293792,-0.011597664,0.0145441,-0.05827366,0.006106364,0.03485486,0.02093259,0.04370721,0.035087973,0.007416844,-0.008449937,0.05126193,-0.022371525,-0.1288883,0.016210591,-0.008662001,0.03579464,-0.05987932,0.0002550834,0.036390558,0.013489177,-0.06057564,0.017214967,0.10055788,0.009222821,-0.0059094136,-0.021360274,-0.050707944,-0.05767364,-0.09883393,-0.006243918,-0.013538449,-0.02543772,0.027447898,0.00068612385,-0.013398569,-0.03997415,0.02656399,0.046957053,-0.023597559,-0.00036497248,0.01755034,-0.0923519,0.051295772,-0.06890974,-0.022774559,8.931868e-05,0.025515964,-0.039097853,-0.00796451,0.09066031,-0.11412086,-0.0013463366,-0.035993055,-0.108367786,-0.10331801,0.024384677,0.10507993,-0.04045808,0.04354905,0.008519945,-0.08483836,0.021259176,-0.05861107,-0.06010942,-0.024182213,-0.014500655,-0.03229681,0.026653629,-0.044499107,-0.0018736261,-0.054637134,-0.0046009123,0.007904575,0.033947665,0.046853077,0.033823248,0.017147755,-0.028711092,0.11812458,0.046077996,0.107065514,-0.0426425,-0.048139613,-1.9517522e-05,0.092767686,-0.10479916,-0.04607101,0.02292666,0.014045639,-0.009346262,0.036493026,0.0012835251,-0.039059702,0.03698206,-0.03072058,0.03971403,0.027060393,-0.03917895,0.01885814,0.013821237,0.00021619504,-0.00013722069,0.03253652,0.0527088,-0.06670055,0.061104674,0.057290327,-0.019584525,0.007311437,-0.045820113,1.4450156e-33,0.036675084,0.021386053,0.035728663,0.028198482,0.009803321,-0.00050473824,-0.1026503,0.08029908,0.017102834,-0.046810146,-0.007902893,0.04553156,0.053246744,0.025313249,-0.0022361006,-0.06101336,-0.012071919,0.013668604,0.034014404,0.0068710144,0.046166565,0.060986668,-0.010121632,0.0060282173,0.06443101,-0.04887251,0.0001518184,0.06097814,0.0048216777,0.006726442,-0.0070472187,-0.06398415,-0.060132418,0.019926548,-0.032085538,-0.023012869,-0.03574948,-0.03862177,-0.01882653,0.09830517,0.027184207,0.030835293,-0.016006652,-0.06197386,0.029067285,-0.07237134,-0.03250657,0.12385748,0.04360442,0.06646264,0.00047540368,0.028018497,0.09209665,-0.045191217,-0.0110699935,0.026765937,-0.030053297,-0.019979643,0.049642306,0.07370597,-0.03125999,0.07147926,-0.045634966,-0.023678163,0.0024496946,-0.015820257,-0.06635364,-0.02773772,-0.032178976,0.008688953,-0.00038207785,0.0280158,0.0847531,0.054141276,0.036721237,-0.016721074,-0.13031578,0.07914241,0.045540255,0.03641654,-0.056705777,0.04500385,0.027733067,-0.017552085,-0.059161182,0.030327562,0.04323759,0.022769991,0.021481555,-0.007946036,0.067459844,-0.06409494,0.025534866,-0.040676963,0.09877638,-2.9333995e-33,0.07243335,-0.029875897,0.012991274,-0.111088455,-0.03324903,0.043753553,0.060019758,-0.015905006,0.011129411,-0.018418388,0.1419866,0.030106928,-0.04646616,-0.10022758,0.08413011,0.03648976,-0.02982401,0.037379865,-0.012790116,0.0093578845,0.05244637,-0.010402349,-0.014840046,0.061231006,0.08869685,-0.008876109,-0.03286104,-0.050675195,0.05947857,0.016071867,-0.0357743,0.04433911,0.0070296116,0.014208021,0.0065026847,0.030541552,-0.11453093,-0.012689881,-0.026039269,0.008840762,-0.022670196,0.023240814,0.024239816,0.029633636,0.039188374,0.019240387,-0.08525931,-0.07828168,0.031972032,-0.059304886,-0.02580924,0.045149405,-0.060055044,-0.013617528,0.048303973,-0.01238255,-0.028788142,0.05780712,0.0027208517,-0.05255556,-0.016670173,0.04741684,0.027423576,0.019893762,0.008936269,0.057283256,-0.07838108,-0.01165174,0.03475542,0.028579183,0.077699326,-0.032068375,0.005604543,-0.049543753,-0.06541649,-0.06388526,0.017563486,0.02005193,-0.10048935,0.010928661,0.09290664,-0.046382092,-0.030984577,-0.0027890925,-0.12750778,0.006546991,0.021527266,0.041022565,0.01713793,0.057380445,-0.03530297,-0.005626669,-0.030055806,0.10087234,0.05543525,-4.5209767e-08,0.004127257,-0.06494355,0.090529084,-0.03854504,0.06406098,0.056982614,-0.0121896025,0.012173989,0.052009493,0.028385004,0.0027986232,0.10632045,0.09262165,-0.008640936,0.027816383,-0.063630566,0.006163951,0.053228926,0.055446822,0.009415075,-0.096368514,0.012325341,-0.061561015,0.030023057,-0.00620843,-0.019952627,0.017429825,-0.05762039,0.04210261,0.0039388025,-0.015410176,-0.0072445273,0.047920216,-0.039842702,-0.009254248,-0.013621767,-0.0025110438,0.0022781242,-0.11761548,0.08097302,0.021849202,-0.073561,-0.038492158,0.010930338,0.13758533,-0.0068937447,0.023617784,0.0058407946,-0.027746689,-0.059348132,0.009903223,-0.0034207264,-0.02583382,-0.08009547,-0.08016227,0.026722504,-0.08734525,-0.09388134,-0.01625778,-0.02544499,0.041661393,-0.0028126123,0.18799803,0.009245877 +1.3.99.13,"A flavoprotein (FAD); forms with another flavoprotein ('electron-transferring flavoprotein') and EC 1.5.5.1 a system reducing ubiquinone and other acceptors. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.99.3 (acyl-CoA dehydrogenase), EC 1.3.99.10 (isovaleryl-CoA dehydrogenase) or EC 1.3.99.12 (2-methylacyl-CoA dehydrogenase).",384,1.0,-0.080159895,-0.0010710602,-0.08142434,-0.005208865,0.1009796,0.021290243,-0.031006439,0.029960845,0.019922655,-0.09011279,0.03772878,-0.003148856,-0.04139889,-0.04641012,-0.07151445,0.005870382,-0.033838313,-0.017050665,-0.051082753,-0.009515194,-0.02476143,0.012836207,0.012665274,0.0008221028,0.031378333,-0.028450718,0.010001633,-0.017163752,-0.04416851,-0.03780765,0.1166152,0.0009873029,0.052125357,-0.06089277,-0.10396687,0.05446515,0.042602,-0.037050407,-0.034542922,0.04656831,0.03748386,-0.063542366,0.01007796,0.043750513,0.06023791,0.011451882,-0.049778838,0.09369628,0.0063931914,0.05459538,-0.019753264,0.021859018,-0.085401766,0.07559028,0.020179857,0.040472098,-0.021141136,0.0025198248,-0.07786542,0.015717063,-0.023214241,-0.023463579,0.052855864,0.035699796,0.0329583,-0.036631558,-0.029573828,-0.06829992,0.06737886,-0.040935073,-0.009980983,-0.04626332,-0.08419919,0.046299767,-0.018839145,0.08081535,-0.10102755,-0.0071316413,0.06084815,-0.027916279,0.0443325,-0.023164822,0.04966332,0.023809826,0.04888349,-0.05785636,-0.01499204,-0.06088058,-0.044419482,0.04650766,0.0348002,-0.0027310196,0.039043255,0.042559545,-0.06399318,0.08253699,0.0847057,0.024338352,-0.07409321,-0.031856637,-0.049992356,0.017497197,-0.054152753,-0.028959058,-0.063394286,-0.05788519,-0.027752087,0.041440237,-0.051561784,-0.081621006,-0.017739842,-0.081685506,-0.026724575,-0.049264647,0.023183439,0.005199668,0.026749386,-0.064096585,0.0031325521,-0.008392663,-0.033553496,0.09414324,0.09762804,0.087664634,0.055944473,8.205323e-05,-0.11629148,2.479013e-33,0.058018096,0.023167256,-0.03184303,-0.01301592,-0.011094275,0.014492309,-0.07999869,0.048404623,-0.007866811,-0.042116284,-0.009141027,0.059355684,0.07181239,-0.0056701372,0.054614957,-0.019374266,-0.0027598303,-0.03381954,0.10045501,-0.09695493,-6.578545e-05,0.055153582,-0.012787788,0.032100547,0.029178414,0.00047050673,-0.08423554,0.061766688,-0.003658013,0.031549923,-0.038518313,-0.037819438,-0.060097888,-0.0262622,-0.05440165,0.04441577,-0.09804539,-0.062550925,-0.08546536,0.040603835,6.433997e-05,0.02211474,-0.05920101,-0.023375409,0.08244416,-0.031193098,-0.04995632,0.09614308,0.010055363,0.05842081,0.023513505,-0.01837245,0.13548577,-0.01148086,-0.0729858,0.023854747,-0.014159973,0.04665143,-0.017513234,0.019116148,-0.00594111,0.08655111,-0.016428802,0.05146648,-0.058431137,-0.033499803,-0.024464527,-0.06176849,-0.030063696,0.054997493,0.053736,0.0077870837,0.09654667,0.022966633,0.06497216,-0.028524257,-0.07334886,-0.021170372,-0.014485328,-0.008393461,-0.09689985,-0.0026905406,-0.024206378,-0.013377937,-0.011859686,0.07460127,-0.003950194,0.0076948064,0.03918517,-0.013671871,0.034064353,-0.022352366,-0.008795128,-0.0010162449,0.10918326,-2.4064406e-33,0.029932527,-0.07029375,-0.024355413,0.040313274,0.05308755,0.046854652,0.09037216,-0.046447538,0.073764,-0.017666,0.07652669,-0.06843832,-0.031133242,-0.038654502,0.03960044,-0.0042193313,-0.067217,0.03069531,0.061310165,0.037773408,-0.008858941,0.010617861,0.023072517,0.06319445,0.041008584,-0.019264625,-0.013307341,-0.066621736,0.056972157,-0.012247011,-0.06065922,0.030127369,-0.055413138,0.021230102,-0.05258066,0.037124213,-0.046548642,0.06180283,0.011561963,0.0261968,-0.019904662,0.0051757745,0.0009827261,0.016199835,0.09318641,0.08982913,-0.05479778,0.070470735,-0.003544869,-0.03778094,0.0064810314,0.011533318,-0.044570997,0.08289157,0.0390136,0.0684814,0.08911045,0.04920084,0.005756386,-0.012396731,-0.00027983196,-0.08371995,0.024161328,0.026056472,0.034531888,0.06764542,0.04839389,0.13009155,-0.017833766,-0.019144787,0.11392818,-0.043508496,0.052937157,0.041266054,0.03870481,-0.020413324,0.0018155496,0.04554127,-0.012310955,0.0056363335,0.007536068,-0.035974763,-0.017720414,0.031723678,-0.09565612,-0.0818357,-0.0061551775,0.010119277,-0.001394847,0.07376749,-0.049813416,0.061676472,-0.03468781,-0.040705662,0.052532036,-3.9783483e-08,0.052278962,-0.057836283,0.022399062,-0.019069472,0.1497257,0.024398765,-0.067401886,0.020201677,0.015882824,-0.012329418,-0.008601532,0.09315535,0.028134922,-0.0016690822,0.05719439,-0.052647308,0.059867714,0.020308265,0.0060411044,-0.007118675,-0.07620625,0.0469248,-0.094920255,-0.0372192,-0.029754002,-0.04658239,0.033108227,-0.036473416,0.06483425,-0.049134824,0.015831957,0.033710614,0.019416347,-0.03698407,-0.09008558,0.016474638,0.024824627,-0.049411144,-0.040500604,0.0761653,-0.0964667,-0.051446874,-0.022034962,-0.036134295,0.07513217,-0.007848499,0.05992246,0.0035898788,-0.07134601,-0.030858679,-0.009519683,-0.038881924,0.04448283,-0.056198306,-0.04910843,0.01226571,-0.052365854,-0.11770923,-0.0030701063,-0.1332695,0.004282219,0.012962328,0.13662298,0.03318364 +1.3.99.14,"2,6-Dichloroindophenol can act as acceptor. The corresponding ketones of cyclopentane and cycloheptane cannot act as donors.",384,1.0,-0.0790173,-0.039878603,-0.004434151,-0.039155938,0.024357984,-0.018636486,0.004754726,0.037429944,0.06605389,-0.035556417,0.030282466,-0.04311558,-0.047954425,0.031187449,0.0013466096,0.1096445,-0.07587853,0.07536334,-0.08659501,0.08042868,-0.0057539176,-0.03969906,-0.00012981154,-0.023689292,-0.02179498,0.06880706,0.0072145504,0.044195797,0.018435718,-0.044013504,-0.013036835,0.039984696,-0.056640785,0.02275151,0.037058134,0.05940272,-0.0839311,0.028283391,-0.009151944,0.03079045,-0.014085506,-0.045255583,-0.017027363,0.0019118986,-0.014769537,-0.04629248,-0.012830141,0.038975585,0.020921862,-0.10275174,0.10355129,0.02969439,-0.013387939,0.062270965,-0.034319,0.09576307,-0.10948785,0.0112925675,-0.0050496208,-0.01115246,-0.016281754,0.023555232,-0.034805473,-0.0019586906,-0.017296387,-0.0010860448,-0.013901279,-0.06053744,0.030953884,-0.051106434,0.022644032,-0.02173392,0.045349315,-0.053209383,0.039593752,0.08228298,-0.039317716,0.019059688,-0.0341885,-0.05697581,0.0211467,-0.062243197,0.08413444,0.030594986,0.081967965,0.010222727,-0.04364494,0.05826316,-0.043846533,0.10036701,-3.277701e-05,0.060626213,0.04128212,-0.08470627,-0.04062667,-0.0016766367,0.041024636,0.025940005,-0.016211132,0.06440678,0.054839004,0.038545597,-0.0942992,-0.042322565,-0.026710413,0.010306445,-0.0017153383,-0.05070421,-0.03187082,-0.032717902,-0.015205417,-0.08792324,0.11055615,-0.0023939903,-0.0097501315,0.06589667,-0.022001479,-0.020962484,0.010223104,-0.034174405,-0.030297045,0.025993085,0.025235817,-0.00089639804,-0.09899218,0.07004602,-0.0019788814,5.2651887e-33,-0.042038273,0.056258105,0.075124994,-0.011023526,-0.04405568,0.0073963758,-0.055620838,-0.020029357,-0.026432335,-0.1650797,-0.03757196,-0.022112373,0.047925394,-0.018926488,-0.010390477,0.04173923,-0.012492892,0.036794525,0.051910788,-0.03868054,0.015409485,0.033825915,-0.05820825,0.0068842,-0.029791808,0.023192557,-0.022868825,0.02173531,0.049334336,-0.005482571,-0.03983924,-0.022801397,0.048620682,0.09242041,-0.07359811,0.033518493,0.02542253,-0.025397968,0.011220619,-0.07657902,-0.02354987,-0.044149317,-0.06601726,0.038287036,0.030551016,-0.017597783,0.019240234,-0.07380551,-0.07191879,0.046040084,-0.027444148,-0.05655802,-0.046388797,-0.05137076,-0.008297069,-0.024826294,0.025279762,0.0355553,-0.00883679,-0.002012182,-0.019846315,0.09081521,-0.007345289,-0.051093116,-0.025807155,0.023753705,-0.07680815,-0.027776254,-0.13615009,0.043079954,-0.05691039,0.0134513,0.009421021,0.081212625,0.07197867,-0.028724948,0.00068493106,0.0054513183,0.05110524,0.046043787,-0.001606395,-0.068427175,0.03584624,7.88141e-05,-0.10079059,0.03143103,0.012235598,-0.10793947,0.055593107,0.017748764,0.031959467,-0.09396716,-0.05219679,-0.01399645,0.03388937,-4.995934e-33,0.04528304,-0.016567647,0.051410306,0.04057848,0.05339372,0.07886119,-0.036157835,-0.119057134,0.08685005,-0.02639177,0.08472962,0.010578966,0.088686526,-0.008331206,0.0053852755,-0.064344384,-0.013044857,0.12502761,-0.004400108,0.05052301,-0.011893061,-0.010597861,-0.057342824,0.07703573,0.015189806,0.06653984,-0.00596065,-0.04985413,0.106119744,0.037583776,0.0027577905,0.045748364,-0.0046274797,-0.003336701,0.067810014,0.0490172,-0.062569186,-0.052817233,-0.08042991,0.06583215,-0.116784856,-0.065008745,-0.025078483,0.028743146,0.012227985,0.0048461966,0.08039225,-0.032585252,0.02374902,-0.0781049,0.048634518,0.043513797,-0.057740636,0.075156815,0.060905736,0.083485804,0.078674994,-0.052152306,0.060183275,-0.04459117,-0.009575546,-0.059701946,0.0074148374,-0.007377889,0.023179438,-0.014745448,0.011852786,0.1870441,-0.007410722,-0.04518027,0.07762553,-0.04007312,0.08687859,0.034999818,0.04296321,-0.02984279,0.0031591703,-0.048327923,-0.0010568063,-0.057510443,-0.05772403,0.030041374,0.027002687,0.0056889225,0.030400196,-0.101967685,0.08267773,-0.0063008247,-0.08772892,-0.0056150015,0.0031414786,0.08762353,0.033549525,0.116929404,0.09045434,-3.26831e-08,0.061347287,-0.090538815,0.022649122,-0.04903866,-0.035005193,-0.025899814,0.06654579,-0.011524442,-0.02065325,0.027853021,-0.022579996,0.02150701,0.03815775,-0.014788518,-0.024439426,0.04413438,-0.03216561,-0.028446425,-0.012429088,-0.02189634,-0.04214788,0.006433654,-0.025490765,-0.07545249,-0.020580132,-0.030477608,0.033419576,0.060194112,-0.017706696,-0.0006273407,0.044540104,-0.046178084,-0.075285226,0.019130915,0.03473317,0.061030436,-0.017833205,-0.043765295,-0.07976025,0.033342708,0.0041009784,-0.074380636,-0.11559821,0.04845947,0.017760895,-0.006652422,0.028744848,-0.028186785,-0.031966805,0.047191653,-0.018107383,-0.009996671,0.044886712,-0.029945992,-0.037999645,0.058386736,0.0018700745,0.03364408,0.0075618913,-0.09854769,-0.030915393,-0.011203615,0.12919435,-0.017270686 +1.3.99.15,"An iron-sulfur protein. Requires Mg2+ or Mn2+. Reduced methyl viologen can act as electron donor. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate + H2O = hydroxylamine + reduced acceptor + 2 ATP. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.",384,0.99999994,-0.05219912,0.023689229,-0.017900275,0.026149405,0.08751673,0.046107247,-0.008215495,-0.011283739,-0.030963728,-0.038442638,0.016294118,-0.05012719,-0.053230416,-0.016760457,-0.0033016298,0.043596808,0.009266732,0.032729864,-0.0026646247,0.00082933105,0.07494477,-0.030713571,-0.01591583,-0.10676077,0.0079252515,0.08762574,0.0325896,0.0061760643,0.034514733,0.0050535984,-0.041875146,-0.036578983,-0.010453175,-0.08310859,-0.01370605,0.09841025,-0.0403192,-0.07653732,-0.059053067,-0.059919097,0.03320545,0.0022803508,-0.029595463,-0.064126045,-0.06520898,-0.08432335,0.12230161,-0.018946765,-0.024018958,-0.04702035,-0.06521521,-0.022479322,-0.03892433,0.036367897,-0.03463132,0.0022300666,-0.091355555,-0.045851003,-0.06185231,-0.050328214,-0.023428835,-0.025534108,-0.04099315,-0.05662068,0.08268493,-0.060784392,0.033487555,-0.009040598,0.022436725,-0.032530647,-0.03040839,-0.024394045,-0.08582207,0.035322234,-0.0548542,0.03264682,0.0070577185,-0.077647224,0.13386029,0.004889072,-0.03228813,-0.002136246,0.020742219,0.106839605,0.10761129,0.0015722881,-0.013924955,0.014895633,-0.016872775,0.06929546,-0.027711893,0.012200928,0.039658558,0.0048953323,-0.026997428,0.058343716,0.030883003,0.043305464,0.0116431555,0.052986503,-0.012679269,0.112614214,-0.03514286,-0.07900164,-0.0028008204,0.033668984,0.0056463326,0.13921107,-0.0030004464,0.053289514,0.01526699,-0.017423492,0.054268543,-0.024704797,0.0030583672,0.107829824,0.007092116,-0.102603644,-0.08640135,-0.024579508,0.014628532,0.01795545,0.053752642,0.057444997,-0.034673378,0.042437524,-0.1308547,7.434518e-33,0.026507465,0.045894314,0.07122669,0.019025581,-0.056886975,0.032153323,-0.06448641,0.009048049,0.025843883,-0.039002806,-0.08311801,-0.10260033,0.08040948,0.05706546,-0.03563807,-0.09628735,0.0057218475,0.03361617,0.13769569,0.0031297235,-0.006072111,0.08659562,0.021611301,-0.034189902,-0.029346464,0.01905936,-0.02309889,-0.0064324574,-0.042051245,-0.0052012615,0.011946128,-0.0660336,-0.09114156,-0.009404367,0.054369498,-0.017979778,-0.058870785,-0.05512847,-0.018622596,-0.0057769064,0.0029488704,0.027314553,-0.089256346,0.0066205375,0.082514495,-0.07148822,-0.023535473,0.029265301,-0.039025847,0.053038515,0.010118554,-0.00953039,0.052622017,-0.040552866,-0.13151866,-0.012202538,0.06443818,0.01420246,-0.034749985,0.064374454,0.021270385,0.035956606,0.013267265,0.069618575,0.013664814,-0.051442355,-0.02763488,-0.052721057,-0.037940435,0.05958724,-0.038509924,0.0045538284,0.061637342,-0.0075549223,0.020655878,-0.0746819,-0.044176552,-0.041490808,0.066062205,0.038003784,-0.02633374,-0.042851433,0.00012319566,-0.014150038,-0.06664641,-0.033424184,-0.011826599,-0.04417441,0.06080213,-0.039733507,0.049626753,-0.070257865,-0.07250861,0.02648038,0.025718413,-8.994383e-33,0.040911473,-0.011190139,0.0040697674,-0.096450105,-0.068983205,0.04303462,0.07156176,-0.0663489,-0.00054975925,0.004896368,0.080081284,-0.06101452,0.070391566,-0.057208475,-0.01527373,0.04862385,-0.013715946,-0.0093124565,0.038065705,0.010170067,-0.0026975013,0.13826859,0.027839152,0.061630834,-0.0035620276,0.0051043173,-0.009097208,0.0031343896,0.068219624,0.0876876,0.048077147,0.022664025,-0.030065652,-0.10648116,-0.0052662315,0.06512098,0.008407538,0.030822355,0.04227204,0.01900378,0.028270418,-0.021617185,0.04902971,0.11327157,0.01539148,0.027035004,-0.06674776,0.0032760783,-0.036076322,-0.05913613,0.07716111,-0.0072206277,-0.024601925,0.027961645,0.03466161,0.024411276,-0.0023180705,-0.0033218418,-0.010880278,0.031795267,-0.08895027,-0.020666819,0.06276026,-0.035380196,0.02018425,0.047079664,-0.0027013968,0.039981663,-0.0063867345,-0.010506775,0.05579885,0.06481117,0.060633965,-0.020927176,0.07276469,-0.0065003093,0.0068266336,0.04283962,-0.022120306,-0.070079915,-0.024276733,0.044924043,-0.025053993,-0.10583133,-0.0013768998,-0.06603693,-0.029288106,0.032778643,-0.024723373,0.02888501,-0.024420807,-0.03352207,-0.028738573,0.07145152,-0.058169555,-5.0239684e-08,-0.053018037,-0.040113527,0.044129804,-0.024662381,-0.0022060727,0.054807268,-0.0063577546,-0.07012326,0.095779374,0.023494426,-0.0026566694,0.09501818,-0.008774506,-0.010296361,0.03352836,-0.0094558075,-0.053693224,0.0933711,-0.065334775,-0.074358724,-0.037703622,-0.026674805,-0.0750731,0.06769839,0.08142455,-0.059117123,0.013673335,-0.064254895,0.029170187,-0.025738647,0.035226822,0.045557246,-0.025082206,-0.0033770616,-0.04635432,0.029611547,0.038517747,-0.048746265,-0.056001507,-0.042725272,-0.026247146,0.0041337702,-0.08170734,-0.010719735,0.07061822,0.076453,-0.056165658,-0.010503179,-0.035544906,0.02386985,0.06723068,-0.050968036,0.033890907,-0.07601764,-0.12981226,0.0472367,0.01639688,-0.020136027,0.0512735,-0.06470877,0.06777968,-0.031335972,0.11395862,-0.041710343 +1.3.99.16,"The enzyme from Pseudomonas diminuta is specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors include 1,2-benzoquinone, cytochrome c, ferricyanide, iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue and phenazine methosulfate.",384,1.0,-0.07061894,-0.010291375,-0.04586448,-0.035343956,0.03221398,0.025831962,-0.048580583,0.070548765,-0.02445238,-0.07817518,0.051520687,-0.07641927,-0.08632109,0.12470995,-0.03289254,0.041015077,-0.03600152,0.00011149521,0.03838564,0.05484663,-0.012732348,0.102890685,-0.045194387,-0.008906153,-0.011950307,0.034596108,0.045772422,0.054554515,0.016651696,-0.0091801025,-0.037411474,0.01221198,0.07157611,-0.038812857,0.036246117,0.0030139338,-0.07359358,-0.002258759,0.08029818,0.021549426,0.085505046,-0.025098193,-0.0036508064,-0.07483265,0.03263409,-0.05805414,0.035995685,0.03980828,0.09860845,-0.040965803,-0.030315846,-0.049365647,0.028630216,0.16244005,-0.046828385,0.008056941,-0.0011775095,-0.06045768,-0.024751442,-0.004263338,0.0077621075,0.013860812,-0.009147916,-0.040253673,-0.028795127,0.034045245,-0.015053075,-0.053506467,-0.009153766,-0.060955793,-0.080030926,-0.035311215,0.014835397,-0.01893072,-0.0049851835,0.034562543,-0.0038057896,-0.013826092,0.034451596,-0.10643459,-0.010840578,-0.071385734,-0.022046246,0.09767035,0.023468295,0.006200498,-0.018403687,0.047419768,0.0638725,-0.010604187,0.01593478,0.030782657,-0.024478232,-0.07660614,-0.08836109,0.03584977,0.03689871,0.06618621,0.05483625,0.013180823,0.03774401,-0.0059182635,-0.088692896,-0.0848383,-0.08499402,0.060556278,0.07920294,0.03365452,0.03501993,-0.06386973,-0.04152286,-0.025473515,0.033586282,-0.053414162,-0.02702991,0.0109691005,0.08671839,-0.03413974,-0.030442208,-0.011171845,-0.040770974,-0.05001632,0.07679509,-0.00358783,0.010328997,0.02129955,-0.05988114,8.0042805e-33,0.092502035,0.042138714,-0.02906914,-0.039664958,-0.010563952,0.025664097,-0.07054923,0.018657036,-0.06108931,-0.11163008,-0.04146515,-0.018373076,0.02908003,0.033275302,0.01792925,0.056996554,0.025240595,0.01966578,0.088794105,-0.024686117,0.059892353,0.020041374,-0.071934305,0.0076322476,0.041500203,0.060902108,0.0023084774,0.02993301,-0.1009567,-0.01717174,0.038684428,-0.013016029,-0.058984905,-0.007760028,0.082856484,0.057840142,-0.0558439,0.037355542,-0.01077505,0.015591392,-0.003946802,0.0904231,-0.008909061,0.01868043,0.045486502,0.032577287,-0.077100396,0.12107002,0.022497363,0.11489291,-0.0009817977,-0.04368972,-0.017750954,-0.029761763,-0.031399626,0.039015077,-0.0059369975,0.025969218,0.059326753,-0.016609423,0.04282399,0.06713343,-0.09778931,0.010821158,-0.014630304,0.0050566024,-0.015379505,0.007145409,-0.009284303,0.0012743169,-0.09369283,0.051838327,0.019495033,0.046045724,0.01386848,-0.07291753,-0.07654102,-0.0920403,0.06457288,-0.019861806,0.011011605,-0.04542627,0.00859631,-0.1116519,-0.11708667,0.006440359,0.006991281,0.002832093,-0.01916147,-0.09349086,0.0992284,-0.095185846,-0.07363417,-0.02231342,-0.005373868,-7.858793e-33,0.1175249,-0.061723553,0.03818418,-0.05762682,-0.019422742,-0.003055994,-0.03641129,-0.027981464,0.02813342,-1.9370538e-05,0.11832549,0.05015421,0.02152139,0.034697153,0.040296663,0.0155469645,-0.022755649,0.047494475,0.08380893,-0.064154446,0.00097026443,-0.014558682,-0.051641423,0.042846132,0.04246829,0.022895167,-0.03158447,0.042692456,0.072663985,0.10848146,-0.05708261,0.06099845,-0.026067238,-0.063308075,0.10455829,0.02902109,-0.018559322,0.028193785,0.017001836,-0.034877814,0.040916663,-0.013749069,-0.038947165,0.039871193,-0.06296399,0.07675287,-0.092423774,-0.0021985695,-0.0020816377,-0.0139438445,0.017768223,0.036537915,-0.008953967,-0.0006585659,0.034652404,0.098966084,0.0007730048,0.008707694,0.051758267,-0.08326188,-0.024419414,-0.13247688,-0.01373744,-0.022870189,-0.02009422,0.052339297,0.0069753295,0.040286012,0.0015907625,-0.03433594,0.016910886,0.0033809748,0.04254317,0.02271582,-0.15655604,-0.016622944,0.039078746,-0.03474646,-0.04318037,0.047009453,0.097719744,-0.025190614,0.00010764655,-0.049866736,-0.003442819,-0.0069617224,0.014106566,0.061831456,-0.04214265,-0.006779027,0.022344511,0.027516661,0.04489412,-0.028358404,0.0038801723,-4.711566e-08,0.054446556,-0.057994395,0.036254056,-0.03137134,-0.027598605,0.010799487,0.008103579,0.006488951,0.053750366,0.030920444,0.03599271,0.10644207,-0.041993797,0.021075934,0.08101352,0.012608625,-0.05982418,-0.037055783,-0.024594016,0.023662644,-0.060377236,-0.009553338,-0.10273761,-0.047092266,-0.00036068502,-0.05852654,0.07275134,-0.00048525754,0.013754747,-0.055065513,-0.013852311,0.019958911,0.027149703,-0.055030975,-0.019293947,0.028246824,-0.032295104,-0.06999899,-0.037057046,-0.026216175,0.03881721,-0.07662139,-0.10768908,-0.043761715,0.0814234,-0.0454129,0.020201316,-0.00047249164,-0.022050386,-0.05812779,0.045325663,-0.06135444,0.060862534,-0.02941076,-0.087356,0.06180207,-0.0038792887,-0.012109616,-0.04494919,-0.012276258,0.0073753553,0.023801662,0.13106944,0.029368378 +1.3.99.17,"Quinolin-2-ol, quinolin-7-ol, quinolin-8-ol, 3-, 4- and 8-methylquinolines and 8-chloroquinoline are substrates. Iodonitrotetrazolium chloride can act as an electron acceptor.",384,0.99999994,-0.061834127,-0.0048975158,-0.044145808,-0.058125667,0.13019949,-0.049948942,0.09030508,0.09240519,0.035515618,-0.025304908,0.0517449,-0.022288049,-0.033592626,0.11008363,-0.006941816,0.07093673,-0.03580073,0.030443102,0.039093666,0.02184248,-0.043719996,-0.014262365,0.012926751,-0.023119826,-0.0034220626,0.055827104,-0.009457092,0.07602855,0.033693463,-0.04195841,-0.015122912,0.021850722,0.032122727,-0.021677716,-0.01392426,0.041853227,-0.0857793,-0.04391405,-0.032658186,0.01657021,0.042450428,-0.025141945,0.010818005,-0.055317827,0.034236055,-0.037150692,0.044528745,0.025954328,0.0412673,0.05482988,0.029397829,-0.045610286,-0.059491444,0.06699673,-0.003016574,0.045409318,-0.07394096,0.0065566604,-0.019469807,0.0971954,0.018567562,0.011855507,-0.04885979,0.039880663,-0.02418766,0.05864403,0.023473449,-0.047134805,0.019561954,-0.04568666,-0.024425833,-0.017493045,-0.027859723,-0.016131524,0.063367,0.03590007,0.0037698096,-0.020714272,0.020322258,-0.08437221,-0.0557361,-0.05308429,-0.003086227,0.06894043,0.01102318,0.044052362,-0.08109092,0.04013238,0.02710515,0.03356684,0.008932686,0.011644785,0.012547795,-0.084226094,0.0011995445,0.069853164,0.015010345,-0.020208096,0.03425498,0.044524588,0.03482918,0.028482053,-0.124652505,-0.047888204,-0.05533465,0.046377677,0.03322954,0.016760714,-0.10891641,-0.024417749,-0.03060836,-0.0712291,0.07664172,-0.07339,-0.019210499,0.021322148,0.0777035,-0.04719089,-0.008248712,-0.01134078,-0.026226897,0.038064044,-0.005183249,0.003922274,0.0071911262,0.038808946,-0.00069267297,1.0544903e-33,0.038454954,0.06894562,0.0055498467,0.0050368956,-0.07013502,0.024182254,-0.02033432,0.01046955,-0.09029824,-0.11973261,-0.033085294,-0.037478555,0.061861407,0.0006997831,0.032921437,0.029147347,0.037710384,0.0013116049,0.082000405,-0.03234404,0.02082188,0.10893716,-0.06072471,0.01864636,0.03538952,0.026183998,-0.03749296,0.04805525,-0.02671128,-0.044121858,0.059874915,0.016472379,-0.03220536,0.02619045,0.018416949,0.044224728,-0.08087681,0.011271737,-0.014481207,-0.022003345,-0.043828335,0.050759193,-0.07868966,0.014171598,0.026731811,-0.056452185,-0.022528779,0.04561479,0.116300024,-0.04375917,0.030611096,0.0006260226,-0.05852624,-0.08778869,-0.078117765,0.067159265,0.049190935,-0.017199619,0.01496341,-0.013278072,-0.013351424,0.048048683,-0.058142748,-0.022638626,0.042426173,0.025576875,-0.05170337,-0.0946824,-0.054532543,0.03418095,-0.037600722,-0.0063621504,-0.022625694,0.028052125,0.0466008,-0.0057636113,-0.08722381,-0.08868805,0.06265918,0.0031662935,0.045859918,-0.048662692,0.06396759,-0.022320455,-0.14206856,-0.052630927,0.014547892,-0.04699062,0.04355288,-0.008149451,0.015806336,-0.078786135,-0.04464795,-0.052735474,-0.019504571,-1.8995496e-33,0.06216078,-0.023757296,-0.01959443,0.017318787,-0.02800152,0.096347585,-0.022344029,-0.07515846,0.046875432,0.046912473,0.059657823,0.036574576,0.045246907,-0.042834572,0.009549334,-0.029942784,-0.04525723,0.08074778,0.08081435,-0.021937517,-0.04194023,0.06058239,0.04548368,0.12077166,0.023962395,0.052157965,-0.01972068,-0.06278154,0.082790636,0.08052356,-0.064935036,-0.07455085,0.044714358,-0.012467918,0.069097206,0.045596175,0.03118849,0.008615662,-0.09452848,-0.03408947,-0.060757954,-0.05827243,0.08164856,0.01161493,-0.06853943,0.0332914,-0.056430507,0.07718201,-0.12403734,0.004921627,-0.013662994,0.06520835,-0.07974988,0.004806205,0.08378633,0.11215428,0.027979827,-0.048507597,0.12549485,-0.05245705,-0.021863688,-0.09052949,-0.04086132,-0.048363592,0.03614262,0.03394716,-0.06365709,0.08071074,-0.010797379,-0.048861112,0.07653501,0.06488579,0.08054694,-0.011359176,-0.022652375,-0.033559,0.024646673,-0.029767945,0.0041464195,-0.021781657,0.024888594,0.0010120367,0.014962972,0.029185424,-0.0814679,-0.05231498,0.013159811,0.0772555,0.027173739,-0.021681195,0.023887,0.01808464,9.548414e-05,0.062140327,0.039141666,-3.8837772e-08,0.016045399,-0.03656345,0.0050728857,-0.059527833,-0.114330806,-0.03531385,0.052500702,0.012317642,0.009598665,0.008543548,0.052779928,0.08486737,0.05891951,-0.046631612,0.07427889,0.030234054,-0.011971579,-0.0058537247,-0.053636964,0.045469806,-0.030189838,-0.0037376604,-0.10958368,-0.071499065,-0.0034109212,-0.063043654,0.010549052,0.05513202,-0.015751455,0.03391898,-0.030717468,-0.032140613,-0.029786037,-0.071650684,0.020162705,0.05957246,0.0003340198,-0.08475984,-0.019746406,0.0036818758,0.0067147166,-0.052529797,-0.07084165,0.03234549,0.03342074,-0.015007289,0.026141657,-0.010708328,-0.0059336014,-0.004844479,0.010529845,-0.066515416,0.06616016,-0.06670222,-0.074846715,-0.004807096,-0.014017793,-0.061310206,0.006660378,-0.09340011,0.030777905,0.00037587236,0.17956342,0.0583798 +1.3.99.18,"The enzyme from Pseudomonas sp. AK2 also acts on quinoline-8-carboxylate, whereas that from Serratia marcescens 2CC-1 will oxidize nicotinate; quinaldate is a substrate for both of these enzymes. 2,4,6-Trinitrobenzene sulfonate, 1,4-benzoquinone, 1,2-naphthoquinone, nitroblue tetrazolium, thionine and menadione will serve as an electron acceptor for the former enzyme and ferricyanide for the latter; Meldola blue, iodonitrotetrazolium chloride, phenazine methosulfate, 2,6-dichlorophenolindophenol and cytochrome c will act as electron acceptors for both.",384,1.0,-0.055603884,-0.029737502,-0.041290917,-0.04792861,0.027668925,0.066510215,-0.070615105,0.05877093,0.010700854,0.012399072,0.00214977,-0.05596696,-0.07314854,0.09049187,-0.042500205,0.054981157,-0.03510805,0.018418886,0.023578925,0.0692871,0.012324133,-0.015628135,-0.056521773,-0.047461994,0.0010783852,0.0847597,0.022769973,0.024097787,-0.052384593,-0.04266528,-0.051313583,0.005569432,0.030173039,-0.01679837,-0.008661279,0.004177006,-0.05921207,-0.023834206,0.03083424,0.0086951805,0.018660417,0.038841266,-0.06676402,-0.028129604,0.040515844,-0.026517643,0.058943514,0.02454373,0.016075555,0.008325538,-0.104578346,0.010371314,-0.005926689,0.07101628,-0.025170486,0.0488869,-0.038891923,0.016398173,0.044958495,0.04775816,-0.007497984,-0.019952947,0.0019660604,0.0018019094,-0.04635961,-0.03501239,0.018828837,0.0078494325,0.0324381,-0.085664526,-0.106224954,-0.049392056,0.05037616,-0.045939676,0.037610274,0.038458407,-0.016500955,-0.028212348,0.020330578,-0.106954016,-0.017063128,-0.0890936,-0.0215332,0.08546928,0.056600366,0.019173479,0.005136902,0.041329823,0.07468861,0.055206303,0.06398107,0.042133115,0.06475686,-0.09102337,-0.093793176,0.08643786,0.0036361453,0.05483308,0.012275067,-0.017471297,0.02748559,0.022918556,-0.09137771,-0.11165694,-0.027875109,0.041293878,0.027530782,0.042837165,0.027877431,-0.009945162,0.01826452,0.021349918,0.0017873242,-0.069208525,-0.018710377,0.0945096,0.07942243,-0.061866432,0.025329098,-0.042139404,-0.024878204,-0.07518863,0.058640167,-0.0692965,0.028076902,0.014627447,-0.06848176,8.433247e-33,0.05936169,0.06059312,-0.023935275,0.019622365,0.011247355,-0.022713808,-0.087760285,0.022897081,-0.048037272,-0.11537626,-0.051689073,-0.04754805,0.007020605,0.0034955593,0.026851736,0.058658674,0.0040187393,-0.0607491,0.08224251,-0.030944435,0.054830205,0.036384195,-0.057905637,0.012377316,0.063449666,0.03901064,0.018525507,0.038224027,-0.03457361,-0.022861976,0.056291807,-0.02139777,-0.05898732,0.03480389,0.037280817,0.06419501,-0.017585551,0.021503896,-0.09683893,0.033505026,0.0346602,0.053693924,0.006518526,-0.0066037276,0.045395065,-0.12652582,-0.10456709,0.11438732,0.105419986,0.09211773,0.0008210723,-0.041578796,0.09780224,0.015997346,-0.063130155,0.07836898,0.02078035,0.0066125127,0.04330225,-0.009912357,0.031097893,0.040085506,-0.020108793,0.029567663,0.0027251863,0.026015453,-0.067706704,-0.057579167,0.012646215,0.042926136,-0.071076676,0.040835977,0.060618054,0.053493034,0.0068023656,-0.048656803,-0.05227276,-0.016662933,0.054386154,0.03089717,0.05071817,-0.10041505,0.05259838,0.015637634,-0.0948665,-0.055732287,0.049366567,-0.020811293,-0.0016211808,-0.021146689,0.07148187,-0.07032736,-0.028966147,0.014843866,0.0054840166,-7.408033e-33,0.123895034,-0.026342569,0.07193309,0.012627597,-0.027700195,0.054604877,-0.01779063,-0.064295374,0.011849646,-0.06316929,0.06733719,0.007307402,0.113541014,0.0069186958,0.009863322,-0.0199516,0.04946849,-0.009501357,-0.0019088776,-0.06942672,-0.0412168,0.045958858,0.0030308547,0.035035774,0.064379625,0.015622349,0.038993716,0.015517511,0.009718386,0.05319974,-0.007471336,0.07268602,-0.018073125,-0.058194194,0.016707895,0.07002759,-0.050800517,-0.0015991026,-0.01391446,0.058740515,-0.026610935,-0.029776681,0.0119483955,0.06936005,-0.047370844,0.06935905,-0.053364426,0.00998951,-0.016061611,-0.018522605,0.013332597,0.04123369,-0.08848808,0.04906554,0.10271085,0.04563007,0.00087508356,-0.06909554,0.0022065903,-0.026400257,-0.059787974,-0.102382,-0.034382954,-0.07353816,0.018046753,0.047744058,-0.04864874,0.095547125,0.045628507,-0.09267023,0.107693456,0.023401603,0.038215924,0.04562081,-0.118440896,-0.018653478,0.01969807,-0.018528301,0.016995272,-0.0047120415,0.092134744,-0.005556454,-0.023291627,0.00041091282,-0.057432845,-0.035948098,0.003984112,0.062066797,-0.04460949,-0.05368389,-0.0025394708,0.02022697,0.0016821409,0.061916955,0.027846802,-5.1270963e-08,0.008161317,-0.06553078,0.00030393817,-0.017027672,-0.0075890105,0.011469653,-0.0055137617,-0.010927576,0.01571253,-0.05891429,-0.012805188,0.08212264,-0.02447,0.04001251,0.057517976,0.02891698,-0.06428364,0.0023771701,-0.06818862,0.06531265,-0.07651221,-0.0364391,-0.12421774,-0.021075875,-0.0033418227,-0.052826595,0.018602302,-0.008724258,0.037085224,0.014012713,-0.06925814,-0.0026092748,0.040255196,-0.045068793,-0.06813655,-0.025574682,-0.020808402,-0.0332381,-0.05944553,0.008574736,0.11492839,-0.09872399,-0.13294241,0.01990318,-0.00719503,-0.05856942,-0.019544307,0.011772935,-0.017520467,-0.0548249,0.06310173,0.014371992,0.08507635,-0.06351327,-0.12850238,0.025201,0.030392716,0.0073133716,0.022298457,-0.05209824,0.013751888,-0.020297522,0.11596924,0.04371739 +1.3.99.19,"A molybdenum---iron---sulfur flavoprotein with molybdopterin cytosine dinucleotide as the molybdenum cofactor. Quinoline, 4-methylquinoline and 4-chloroquinoline can also serve as substrates for the enzyme from Agrobacterium sp. 1B. Iodonitrotetrazolium chloride, thionine, menadione and 2,6-dichlorophenolindophenol can act as electron acceptors.",384,1.0,-0.092111126,-0.086422436,-0.12760796,-0.025798667,0.076545686,0.007070953,-0.024404686,0.054178007,0.004943663,-0.07231725,0.0342179,0.028062992,-0.0420517,0.011908687,-0.06883676,0.08205148,-0.0019173156,0.016132392,0.01376295,0.03345766,-0.039400823,0.003883902,-0.02386429,-0.12945157,-0.0080648875,0.07708584,-0.033315077,-0.016896497,-0.033413645,-0.033989184,0.02625689,0.03966202,0.07153055,-0.022100218,0.028015373,0.05693719,-0.0060082856,-0.03195411,0.048971348,0.016397394,0.06900017,0.06595355,0.013799272,-0.05640419,0.009759161,-0.028055938,0.029447965,0.036811076,0.041370865,0.060824625,-0.0053600837,-0.018535653,-0.05408058,0.058144543,-0.02956222,0.032911964,-0.012152513,-0.026265139,0.027021619,0.022705171,-0.0118333725,-0.013656528,0.08373958,0.029198423,0.02762308,-0.05762135,-0.0018956944,-0.0646395,0.021539563,-0.045523096,-0.0774532,-0.002006157,-0.023698907,0.028428018,-0.010806891,0.11900403,-0.02488541,-0.0051537645,0.1314497,-0.07491272,-0.019247238,-0.018978365,-0.0049283993,0.0896058,-0.01019947,-0.036901195,0.010280016,0.044002883,0.035484567,0.039487537,0.03487837,-0.0054954533,0.046556015,-0.040975343,-0.11596324,0.04548784,0.038379543,-0.03518562,-0.07223878,-0.0075942082,-0.007909053,-0.007834506,-0.033165067,-0.064059064,-0.10347067,-0.021232337,-0.021111805,0.074801326,-0.0021533011,0.015178478,-0.015923528,-0.00014454173,0.04564207,-0.09335422,0.02184771,-0.030955518,0.057635613,-0.025860108,-0.044940695,-0.049063206,0.0034702956,0.0066501913,0.03622574,0.016290296,0.04616512,0.04990158,-0.062120005,8.017858e-33,0.13030884,0.043722477,0.05680691,-0.049192186,0.0112569425,0.026884776,-0.05116156,0.061978597,-0.054708257,-0.06363697,-0.030720446,-0.07522434,0.07728714,-0.061747387,-0.021505324,0.07007467,-0.05759657,-0.041479073,0.091339454,-0.0063380683,0.02122803,0.019970316,-0.001648564,0.037338365,0.06898289,0.027282754,-0.035028465,0.030051759,0.025497535,0.0060698627,0.034274466,-0.08888635,-0.086290196,-0.023135852,0.08431558,0.012717539,-0.051286146,-0.047381107,-0.04980836,0.043102477,-0.07876019,0.018940391,-0.029509237,-0.0042681433,0.044555966,0.011138277,-0.05419078,0.09494734,0.037904218,0.041643277,-0.028658804,-0.08334781,0.07511281,-0.019318156,-0.06421334,0.06061365,-0.0064453944,0.05314064,0.007740527,0.020268517,-0.02053221,0.09125533,-0.0061425837,0.030313348,-0.032440063,-0.0122977095,-0.068843,-0.026764436,0.043410055,0.0966485,-0.014464351,0.035926774,-0.023421686,0.052301787,-0.013490989,-0.06207024,-0.01098902,-0.1234128,0.051793188,0.026140064,0.025827272,-0.06476215,0.061090976,-0.075895146,-0.0824542,-0.002961769,-0.08192998,-0.05160698,0.00084138504,-0.024032354,0.07509636,-0.027373256,-0.041268043,-0.014233685,-0.030898402,-7.0895556e-33,0.10753871,-0.097344436,0.03724514,0.01586505,-0.028424362,0.024751216,-0.016428648,-0.028352225,0.01153983,0.017650506,0.024108792,0.021603564,0.040360257,-0.056066208,0.050857775,-0.0029846027,-0.019322947,0.10890209,0.065440334,-0.0054717963,-0.02698663,0.013987152,0.045948204,0.0148430895,0.039406054,0.022679374,-0.05558683,-0.0433036,0.066346906,0.039062344,-0.023235273,0.03677516,-0.043088753,-0.11833671,-0.014708178,-0.0020563048,-0.014422336,0.008364616,0.01922649,0.0050179353,-0.04547548,0.021696731,0.03274066,0.058734212,0.019379368,0.030501889,-0.059335712,0.058799744,0.010596527,0.0413747,-0.009430455,-0.037719153,-0.03089695,0.049330883,0.05911424,0.084569424,0.06695537,0.014191387,-0.0034131804,-0.0054451167,-0.07648652,-0.124691494,-0.0069469297,-0.009759536,0.06598775,0.15690319,0.025817417,0.13099472,0.035096902,-0.08644758,0.04014538,-0.008080895,0.025848294,0.02277655,0.020482305,0.043060884,0.01570066,0.05348833,-0.007421102,0.020642662,0.0133735165,0.02149692,-0.014148708,-0.028136302,0.004990906,-0.047530483,-0.017710194,0.12226861,-0.03221134,0.039207306,-0.08657854,0.009749905,0.01967663,6.823208e-05,0.027986718,-4.720819e-08,-0.017947204,-0.029509936,0.009957651,-0.06631408,0.03774797,0.06406681,-0.008879504,-0.038020555,0.024894074,-0.029610394,0.01561732,0.09057426,-0.0079108635,-0.025267463,0.077002116,0.06307816,-0.055037,-0.06913129,-0.042620517,0.03533609,-0.036543924,-0.005488562,-0.18281874,0.10468822,-0.03161454,-0.058745705,0.025302414,0.0021267217,0.008607649,0.044612944,-0.039351158,-0.0077945753,-0.035085093,-0.083537854,-0.06616461,-0.034025755,-0.0077284775,-0.087047085,0.033544105,0.02332601,-0.023837965,0.007715903,-0.07467928,-0.0038668688,0.0048530423,-0.013529968,-0.033670273,0.05970953,-0.06963478,0.004362151,0.00086458714,-0.058767144,0.0018127201,-0.050425526,-0.08294474,0.046892878,0.04503914,-0.11061497,-0.017672827,-0.02649197,-0.04383571,-0.04475336,0.14504583,0.049261257 +1.3.99.20,A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3],384,1.0,-0.06518032,-0.025515756,-0.12715878,0.07633578,0.11098132,0.041130997,-0.034727592,-0.03075697,0.0356272,-0.10166674,0.006223618,-0.08435307,-0.04777566,0.03860295,-0.055792242,0.010975231,-0.07707931,0.04954102,-0.047277875,0.027660692,-0.017879773,0.013466733,0.06756202,-0.031903252,-0.021661453,0.06619393,0.020569162,0.0040179794,-0.0456547,-0.048403427,0.02259669,0.062471505,0.10707088,-0.044928856,0.020277943,0.121033765,0.060033157,-0.07168051,0.060215734,-0.00856468,-0.019685533,0.039986324,0.06382092,-0.06129657,-0.035185024,-0.03123566,0.035800133,0.0009931978,0.06762588,-0.03013576,-0.017296815,-0.011619303,-0.057567474,0.09575517,0.030472655,0.040872935,0.0075550447,-0.061439227,-0.01967287,-0.05650189,0.019904079,-0.031198462,0.05675047,0.01895046,-0.04634922,-0.02416669,0.01901318,-0.05505701,0.016047541,-0.051939707,-0.058266833,0.008093058,0.041707043,-0.0009196047,-0.041104008,0.13243794,0.08446866,-0.026625255,0.084720746,-0.04044339,-0.05031077,-0.042893406,0.01861775,0.056655265,0.038652334,-0.059835188,-0.06956097,-0.04008306,-0.0077033406,0.08069505,-0.0070529766,0.06734999,0.037597567,-0.038188655,-0.08265181,0.012682464,0.08100162,0.009570145,0.0014011665,0.025174282,-0.034224514,0.07809756,0.01839539,-0.07994989,0.0006226299,-0.06221779,0.005141978,0.1398033,0.043124683,-0.002601679,0.05592824,0.007855372,0.0966039,-0.038291775,0.015897661,0.053593148,0.030273193,-0.037619416,-0.08711868,0.020285312,-0.0068050246,-0.027777057,-0.004737534,0.020140111,-0.026193941,-0.057208907,-0.10909029,1.3560994e-33,0.14929527,0.01716376,0.043917082,0.026989808,0.017872712,-0.041786727,-0.11546563,-0.017997464,0.047865722,-0.07650567,-0.06898635,-0.04143767,0.10942372,-0.078691036,-0.01443653,-0.067540154,-0.09688399,-0.0659385,0.093237735,0.0035508103,0.025876125,0.03337937,0.038852077,-0.02408634,0.039887484,0.082432434,-0.0012657972,-0.02819554,-0.029012661,0.027261838,0.049721565,-0.06853598,-0.10871328,-0.002859516,0.026063567,-0.0056099454,-0.034445673,-0.055125523,-0.05567268,0.025014471,-0.055664845,0.022120148,-0.0067097535,-0.060271412,0.056662973,-0.008388689,-0.0335473,0.095659375,0.05643039,0.08584312,-0.0008357138,-0.08066423,0.081808254,-0.0022161964,-0.074690245,0.042959448,0.016531425,0.030484365,0.009684759,0.05401416,0.040672783,0.064792745,0.0038390406,0.052129127,0.006458839,0.028669918,0.00097636983,0.0044485503,0.028148526,0.07214233,-0.030586254,0.034788214,0.06610871,0.040117647,0.010603361,-0.0114626475,-0.02577945,-0.1035442,0.022389635,0.0038807145,-0.003183419,-0.058669224,-0.015454934,-0.0697291,-0.047834173,0.0158967,-0.047416996,-0.0017585834,0.005068361,-0.026981631,0.04281182,-0.047085132,-0.03678617,-0.034742173,-0.08444933,-1.8755883e-33,0.0764239,-0.06403147,0.015206806,-0.035934713,-0.0785427,0.021657513,-0.053624168,-0.009189476,-0.009177826,0.05279843,0.07486175,-0.0040374747,0.049183235,-0.075826585,0.054888546,0.035680037,-0.0024413103,-0.03576706,0.04808111,0.035017353,0.01820729,-0.018652102,-0.01759126,-0.009427513,0.047856316,0.045814503,-0.052415427,-0.018281536,0.06831445,0.032621365,0.0118224425,-0.00020739024,-0.0628077,-0.105352834,0.009906652,0.010152892,-0.02887631,0.008437045,0.037012618,-0.042486742,0.024584997,-0.010748173,-0.0095825875,0.08852884,0.0516606,0.034161016,-0.08640663,-0.0031109166,0.0029523994,0.028848,-0.035380274,-0.014729178,-0.062782034,-0.009926191,-0.02026465,0.053205647,-0.001908674,0.046884924,-0.0047042845,0.009379819,-0.042468507,-0.10995223,0.06604575,0.048063245,-0.01528902,0.08296806,-0.010266058,0.06270548,0.030607834,0.004118058,0.008018034,-0.016215855,0.04467242,0.07004469,-0.0094588585,-0.0146836,-0.0010335126,-0.00013896966,-0.0039321724,0.049990878,-0.021955423,0.014873961,0.010578148,-0.06928569,0.044291083,-0.10576938,0.014590193,0.08599462,0.026075939,-0.0062112394,-0.025890019,-0.02265045,0.0090544475,-0.050172426,-0.02889935,-3.108137e-08,-0.05196992,-0.05388614,0.050279696,0.008984767,0.04343425,0.067587376,-0.014157728,-0.014428425,0.018485392,-0.0048531285,0.059980504,0.10242963,0.0074700285,-0.05439956,-0.002855979,0.0825872,-0.0900159,-0.05437223,-0.027570369,-0.014012554,-0.05225704,-0.04105319,-0.11872922,0.12051089,0.06695779,-0.057181586,-0.026169505,0.004741161,-0.016279921,-0.07825863,-0.021994416,0.034074947,-0.011543801,0.0025420194,-0.09752591,-0.028809676,-0.037646044,-0.05763893,-0.030573199,0.043243892,-0.038124714,0.019482011,-0.06250603,0.008350338,0.034795776,0.06947255,-0.031095332,0.06285333,-0.009225737,-0.016431035,0.040808976,-0.049833562,0.0087950565,-0.0045635547,-0.13312115,0.08655411,0.012354367,-0.015604908,0.06665295,0.029206548,-0.01757495,-0.017690612,0.07084568,-0.057786647 +1.3.99.21,"Requires FAD as cofactor. The enzyme is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Uses the ferricenium ion as the preferred artificial electron acceptor. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity.",384,1.0,-0.090382025,-0.03275458,-0.16446882,-0.038424782,0.13130848,0.059677392,-0.12647125,0.04620189,0.029597912,-0.031040516,-0.020061191,-0.06400906,-0.06198843,0.04405524,-0.046412382,-0.009931745,-0.025078598,-0.0307797,0.008394228,-0.099265866,-0.024021203,-0.014798599,0.02935789,-0.03987225,0.030413812,-0.083288796,0.0020738523,-0.0073299278,-0.058331564,-0.04028185,0.0794045,0.058900565,0.03607614,-0.03983239,-0.040245965,0.10673236,-0.02706323,-0.0281406,0.059708603,0.065557085,0.0019090265,-0.043445073,-0.0447531,-0.03744972,-0.031217854,-0.083804846,-0.023391608,0.049953263,0.015646905,0.0045931884,-0.022381736,0.028151253,-0.059490588,0.015139972,-0.04267946,0.06190048,0.03537896,-0.048937153,-0.0677005,0.0010208264,0.0048596542,-0.06483912,-0.025468692,0.051229488,0.016477652,-0.055354547,0.010390157,-0.07898101,0.048075885,-0.008357535,-0.049101777,-0.066833235,-0.06565123,-0.0037572777,0.022630392,0.015288439,-0.033838484,-0.014572574,0.07228262,-0.08233319,0.0078418655,0.033465665,0.07291149,0.053392444,0.09121183,0.0047864025,-0.017647173,-0.0662754,0.026200308,0.08037662,0.099813685,0.03872651,0.009934306,-0.0011382063,-0.060261812,0.08405457,0.10144523,0.0084189605,-0.006875762,-0.04734473,0.03319373,0.010229704,-0.025546163,0.016318165,-0.083903365,-0.06506426,0.002479552,0.110811815,-0.022067627,-0.053783048,0.0049687424,0.02190131,0.08063096,-0.03495851,-0.010494186,0.03773343,0.03624363,-0.08265706,-0.012039675,0.014169129,-0.05923097,0.016435308,0.028227234,0.04838932,0.04608574,-0.01859224,-0.12918329,4.9827534e-33,0.114688985,0.055818535,-0.028004471,-0.020562245,-0.060611714,-0.014499967,-0.09010269,0.053614505,-0.02657292,0.0189939,0.007952336,-0.0356508,0.037155986,-0.035759274,-0.03647857,-0.045367416,-0.023904411,0.0073100673,0.017397815,-0.019966697,0.04259303,0.06504635,0.0119062215,-0.001986457,0.045944355,0.049762502,-0.0019025649,0.08263093,-0.009132772,0.02295152,0.027384039,-0.07562719,-0.07017063,0.018466504,0.00418988,-0.019487657,-0.06340802,0.0070459894,-0.052243713,0.043563064,0.06416872,0.075614005,-0.0053120335,-0.020914627,0.018937573,0.006141398,-0.02624447,0.09422344,0.0459247,0.10315855,0.06094527,-0.008339667,0.099993125,-0.016300313,-0.040431432,0.08047096,-0.039647292,0.028814185,0.064446114,-0.0020981508,0.0034083924,0.015208049,-0.02772244,0.09597213,-0.014695862,-0.037453268,-0.066521235,-0.04043822,-0.014254236,0.10585786,-0.042306766,0.017667143,0.05454861,0.049290035,0.08830857,-0.044382617,-0.07912016,-0.031079948,0.049766418,-0.020701678,0.010513007,0.0016309337,0.028095894,-0.02215985,-0.0401749,-0.036800615,-0.049574032,-0.035083927,0.030531261,-0.00540846,0.09458942,-0.070578545,0.0033307965,0.0077103507,0.105194256,-3.962827e-33,0.12597884,-0.087112024,0.02631134,-0.08886868,0.020431701,0.06241046,0.040533725,-0.055388603,0.0728704,0.03612201,0.108417034,0.024740502,-0.012530786,-0.057239372,0.04000011,-0.012526192,0.04755744,0.006044831,-0.01553886,-0.013119317,-0.06679082,-0.009755095,0.017555017,-0.033791285,0.044513468,0.035637636,-0.08003398,0.003554056,-0.0031732654,0.005152506,-0.021290548,0.030278532,-0.05018293,-0.0064343,-0.05189421,0.023337888,-0.06422408,0.0768481,-0.043193884,0.03711593,-0.023100896,0.0073766694,-0.0073812124,0.07068458,0.05763079,-0.039939832,-0.11216751,-0.041363187,0.011465666,-0.027390247,-0.04611727,-0.03991593,-0.009504973,-0.016498871,0.062881395,0.071926996,0.05235028,-0.018217493,0.008360861,-0.025353024,-0.0020757162,0.014977642,0.0034878412,-0.005710814,0.047708288,0.056824394,-0.044118837,0.12849315,0.060093567,0.0017025826,0.099990666,0.026158847,0.04390443,0.049585484,-0.026613437,-0.058217525,0.036369152,-0.0027553427,-0.017987188,0.014393352,-0.017427504,0.0039576394,-0.053188853,-0.02447249,-0.10197356,-0.09649512,0.010149344,0.016418159,-0.024972204,-0.009848863,0.0042089196,-0.0021594765,0.006136906,0.08508686,0.09025706,-4.0637104e-08,-0.054802995,-0.07714501,0.014173932,-0.03553431,0.025717093,0.00015859965,0.018993014,-0.06914075,0.044140596,-0.055898976,0.0033896836,0.072676234,0.08124586,0.030220293,0.0887297,-0.032183,-0.04608103,0.015317639,-0.056517735,-0.0067287227,-0.05154006,0.027047766,-0.10747603,0.03172382,0.03384921,-0.0190553,0.0073734443,-0.015765367,0.0364317,0.038761947,-0.05457594,0.022961397,0.022605319,0.07322841,-0.055549324,0.02051079,0.010453977,-0.055944577,-0.0668942,0.036781784,0.05477914,-0.0005219631,-0.057619385,0.0018377488,0.048781738,0.014190405,-0.055890344,0.003563439,0.018336447,0.021279614,-0.04638459,-0.026561642,-0.02425042,-0.0010289927,-0.046879992,0.040471714,-0.020311316,-0.05848456,-0.010917063,-0.07665978,0.042550992,-0.0060549392,0.1808984,-0.053229023 +1.3.99.22,"This enzyme differs from EC 1.3.3.3, coproporphyrinogen oxidase, by using S-adenosyl-L-methionine (AdoMet) instead of oxygen as oxidant. It occurs mainly in bacteria, whereas eukaryotes use the oxygen-dependent oxidase. The reaction starts by using an electron from the reduced form of the enzyme's [4Fe-4S] cluster to split AdoMet into methionine and the radical 5'-deoxyadenosin-5'-yl. This radical initiates attack on the 2-carboxyethyl groups, leading to their conversion into vinyl groups. This conversion, ---(.)CH-CH2-COO- -> ---CH=CH2 + CO2 + e- replaces the electron initially used.",384,1.0,-0.06299183,-0.0017163208,-0.059736706,0.06227384,0.13160788,0.016957685,-0.08097984,0.028203066,0.029530874,0.0018977391,0.028938405,-0.07177126,-0.11125873,0.0061561833,-0.00667919,0.0335122,-0.08541896,0.012656748,-0.026984908,-0.00092676264,0.028967375,0.02508138,0.01674154,-0.052578676,0.050465792,-0.03227961,-0.0015568724,0.01613189,-0.04548367,-0.067960866,0.09702472,-0.059304215,0.07083568,-0.027901908,0.024569714,0.03527571,-0.02417217,-0.12168716,0.0370206,0.022426005,0.012372862,0.015077975,-0.062076267,-0.012090516,-0.012743145,-0.027157981,-0.042214677,0.006238167,0.024780512,-0.036818586,-0.020273676,-0.021108652,-0.053088658,-0.017238362,-0.046967085,0.007339841,-0.0012152599,0.094843715,0.0047791894,-0.046569843,0.091872975,-0.023013785,-0.025498472,0.007618976,-0.04860831,-0.06502748,0.09687481,-0.055978898,0.06308349,-0.012270633,-0.041223586,-0.046076987,-0.0061181313,0.034449257,-0.02478412,0.0017041519,-0.036826428,-0.060291886,0.047853146,-0.0041995854,0.05526454,-0.012874934,0.0056898477,0.026556933,0.06674639,0.06262008,-0.024152273,-0.026569944,-0.0037053272,-0.011506555,-0.018973844,-0.0023556072,-0.003201706,-0.009549908,-0.02120506,0.018649962,0.09389948,0.09286423,0.01640907,-0.022368222,0.0019147183,0.1111446,-0.054736327,-0.1213922,-0.02277628,0.0042102933,0.070077665,0.06911025,0.01125982,0.042941216,0.020962823,-0.022210406,0.023815682,-0.0592117,-0.05428935,0.14380127,-0.022894591,-0.048245978,-0.008456559,0.043893117,0.08366025,-0.103757575,0.026648182,0.0434739,-0.06703291,0.043165684,-0.087322876,2.0180035e-33,0.060056373,0.04883884,-0.013062755,0.0011818209,0.04651528,-0.020646714,-0.13592784,-0.024652908,-0.030668812,0.008823737,-0.08409945,-0.037970714,0.08201054,0.021442654,-0.071553916,-0.0455919,-0.11936352,-0.019024968,0.0063709216,0.030223029,0.004213499,0.018348908,-0.07729025,0.077817485,-0.024721052,-0.022066552,-0.010912732,0.0403269,0.05206305,0.028134523,-0.07357589,-0.061108004,-0.082769305,0.039658085,-0.023421293,0.039177287,-0.06339031,-0.06695273,0.041162703,0.0134084085,0.028422201,0.018183446,0.009304801,-0.050910484,0.10253197,-0.01416808,-0.07535098,0.06603676,0.06305792,0.09349877,0.007614392,-0.027009247,0.09143596,0.020346973,-0.07446057,-0.0027800726,-0.0060571074,-0.02858751,0.011138201,0.07885715,0.001289056,0.07459444,0.028298656,0.015120731,-0.01660824,0.062152006,-0.036978535,-0.04656087,-0.009937848,0.050901223,-0.004491989,0.008321211,0.05614579,0.02587038,0.051495902,0.047577687,-0.023372512,0.07397227,0.028105576,-0.018357392,-0.004296985,0.015622664,-0.007062268,-0.07599653,-0.029377356,0.0060335426,-0.028024528,0.016568283,-0.013521611,0.036369238,0.07276914,-0.1053253,-0.0009647606,-0.024387712,-0.04001287,-3.6192336e-33,0.065275215,0.0051443237,0.030391619,-0.119754694,-0.038503077,0.074787125,-0.046921477,-0.04236229,0.060624704,-0.0078967195,0.06989322,-0.032618392,0.02385212,-0.043251395,0.051174283,-0.009686674,-0.051091693,0.022307146,-0.0016480848,0.03183947,0.09801892,0.013325465,0.0115594985,0.07240303,0.086707614,-0.021280628,-0.0055226604,-0.022481943,0.10077548,0.03859319,0.0027312099,-0.05369004,0.004608516,0.027918484,0.019467968,0.04380024,-0.069452934,0.06722963,0.01099241,-0.0061812126,-0.039788175,-0.023591114,0.03025875,0.043982606,0.057158537,0.058719527,-0.073478945,0.018121114,-0.017007245,-0.092506744,0.033049054,-0.0051397504,-0.009738734,-0.052485988,0.0026910354,0.1321686,0.04319309,0.004516478,-0.07944096,0.01979138,-0.02638906,-0.023090208,0.065517604,0.0067526596,-0.011331134,0.01916354,-0.028230207,0.06581603,0.0037113333,0.008082973,-0.028974295,0.03702723,0.015245682,0.024184912,-0.06157594,-0.06900558,-0.10454223,-0.023393534,0.0044350172,-0.034391135,-0.014812452,-0.0291997,0.042549808,-0.08013635,-0.05891392,-0.013168621,-0.0028685709,0.06928825,0.017458355,0.037418846,-0.06108401,-0.0016988297,-0.0070073074,0.07872285,0.07159602,-5.2932723e-08,0.07004837,-0.022904873,0.09472102,-0.036731094,-0.0067831236,0.032475103,0.0066608847,-0.032346915,0.039442692,-0.037517488,-0.022095129,0.09747379,0.0128048,-0.012851163,0.0013533274,0.028695976,-0.06648602,0.04004195,-0.020277089,0.014983345,-0.047307577,-0.029234873,-0.078413166,0.023832994,-0.016750047,-0.029002609,0.044654276,0.097744845,-0.00049503497,-0.059847407,-0.026975745,0.022259735,-0.07591585,0.017903548,-0.14078568,-0.019954741,-0.081218734,-0.06142004,-0.08779755,0.040570043,0.007867438,-0.04316408,-0.05003723,0.06887322,0.017608967,-0.010260677,0.050678577,-0.009252868,-0.015124012,-0.035028286,0.059699137,-0.04929867,-0.046588723,-0.043804273,-0.11551816,0.043596383,-0.10922513,0.055568323,0.011295964,-0.009178442,-0.051058028,0.04445767,0.16763377,0.062108956 +1.3.99.23,"The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A.",384,0.99999994,-0.060417082,-0.025406796,-0.057809226,-0.04167608,0.016080342,0.06782995,-0.00068653387,0.042692814,0.037815303,0.042149283,0.104826525,-0.031221705,-0.040869057,0.031785984,-0.05490461,-0.05514352,-0.052373514,0.05869697,-0.04171512,-0.04485695,0.0067799105,-0.02337873,0.039327886,0.019079426,0.026601588,-0.023034908,0.06621839,-0.038695037,0.002516595,-0.027383527,-0.06081845,-0.008626907,-0.060480196,-0.020961242,-0.04372078,0.07979518,-0.059634954,-0.084755324,-0.033668812,0.049314104,0.054914042,0.0007066598,-0.049016193,0.019284392,0.07896642,-0.07713294,-0.007565788,0.019228434,-0.0108806975,0.03429172,-0.05659681,-0.031164905,-0.09629161,-0.0077984463,0.0019387975,0.05593431,0.01843846,0.016096525,0.052247435,0.07379506,0.067149736,-0.08532678,0.013818465,-0.039231434,0.076278746,-0.057591833,0.042812888,-0.06079332,-0.034052644,-0.052942976,0.002131113,-0.09246206,-0.046005882,-0.063201696,0.014070479,0.038603052,-0.053186838,-0.005005384,-0.006317424,0.017281909,0.07849429,-0.0090798335,-0.037719518,0.0834454,0.08180524,-0.08122239,-0.009675339,0.0014820525,0.07476059,0.1177215,-0.07454944,0.039527044,0.008726108,-0.013506166,-0.061867993,0.016872754,0.025142135,-0.022406785,0.023759503,-0.0285177,-0.026601778,0.01914846,-0.06633372,0.004317234,-0.11437363,0.024081787,-0.066020034,0.089995064,-0.07642611,0.019932063,0.0417432,0.042041503,0.009891923,-0.017560994,0.0018459811,0.08633599,0.036225718,-0.09371256,-0.035726484,0.020055255,-0.09938612,0.03065117,0.07491441,0.02472482,-0.021614257,-9.916647e-05,-0.026770057,-1.4597367e-33,0.019822335,0.06902614,-0.020250691,0.022183448,-0.028699106,0.048544966,-0.09520827,0.08877924,-0.037016667,-0.094687305,-0.0043948554,-0.039796613,0.005567782,0.043645307,-0.02402477,-0.009724585,0.10644248,-0.004082493,-0.005981131,-0.05828465,-0.026399117,0.0154242385,-0.050384082,-0.018661728,-0.04244769,0.040598415,-0.043367464,0.058009796,-0.039879236,-0.023253182,0.003469987,-0.039409094,-0.03243844,-0.011754251,0.1361705,0.058052026,0.014619806,0.02410117,-0.0074891974,0.053317655,-0.022827057,0.019829212,-0.013464928,-0.04970692,0.10492057,-0.0075298883,-0.043238696,0.05457409,-0.026936783,0.013249658,-0.020999428,0.03377011,0.028935967,-0.02518658,-0.03671411,-0.0012320522,-0.060557034,0.012789151,-0.030387701,0.08098165,0.03662459,0.047578707,-0.058343172,0.08626756,-0.046312556,0.045599613,-0.09174152,-0.07492849,-0.029694168,-0.013549984,0.037491042,0.062635474,0.12813736,-0.024052909,0.0346603,0.0367298,-0.14182551,0.07085757,0.0051936693,-0.02321249,-0.020982495,0.03801401,0.003975496,-0.007917201,-0.07875845,-0.0019842659,-0.0033266656,-0.037136782,0.05208144,0.0011774139,0.09202462,-0.04100361,0.0041885288,0.004456806,0.08400965,-6.0672673e-34,0.058797788,-0.08733253,0.015159862,-0.15918198,-0.052717194,0.02358019,0.034906592,-0.07352864,0.017693793,0.00076813326,0.05566646,-0.07057731,-0.051059775,-0.03740035,-0.040211678,-0.016557548,0.05194882,0.10955585,-0.0057675363,-0.030946745,-0.0304035,0.0016838886,0.019322392,0.062058505,0.052980933,0.055279415,0.0496546,0.073624775,-0.03392702,0.071176015,0.0035622849,-0.030077025,-0.00917423,0.048292916,0.021142878,0.079327986,-0.08407112,-0.013124824,-0.015330277,0.04768975,0.022931922,-0.060833875,0.0078096134,0.02808058,0.007565352,0.030098291,-0.012535918,0.0017637864,0.02796733,-0.055977028,0.04752473,0.023878697,-0.023947395,-0.009640338,0.023714479,0.092034236,-0.027155,0.010140364,0.06083442,-0.035308346,0.043543175,-0.062741324,0.008458814,-0.084760986,0.02616053,0.053077754,0.043135926,0.042472698,0.08078353,-0.06863265,0.13383734,0.04330207,-0.017380483,-0.0052484777,-0.07278758,-0.04635656,-0.009028793,-0.053910345,-0.043199908,-0.0380383,-0.069604024,-0.072630614,0.0050717276,-0.0053144204,0.01469158,-0.063025296,-0.05832211,-0.0071067177,0.019151563,0.0028060214,-0.01845077,-0.01611971,-0.08100676,0.011132626,0.1236766,-3.5731397e-08,0.0385961,-0.05317036,0.013678697,-0.001387339,0.026002524,0.025801247,0.004143146,-0.0147689935,0.085451126,-0.015361719,-0.08561011,0.07790787,0.017194541,0.04827518,0.048434895,0.03535717,-0.026374849,0.011992507,-0.011621834,-0.023102518,-0.10458775,-0.0267194,-0.016863411,-0.029496253,-0.10333171,-0.0816829,-0.04935846,0.08035703,0.057681724,-0.037558254,0.09291466,-0.042987693,0.025604878,-0.02945769,-0.001867029,0.0045796228,0.11240162,0.016170442,-0.008606238,0.034329273,-0.03559019,-0.064301156,-0.0841401,0.09774358,-0.00054826064,0.024191763,0.01962649,-0.008904442,-0.012248825,0.07941418,0.011712868,0.015077234,-0.007699417,0.00604669,-0.07333794,-0.040814772,0.03290852,-0.050683282,-0.06572603,0.022539997,0.06606191,0.034287002,0.09941659,-0.03908038 +1.4.1.5,Acts on aliphatic amino acids.,384,0.99999994,-0.017784799,-0.13856018,-0.038469587,-0.009831972,0.022573102,0.092057794,0.11232008,0.055458315,0.10343231,0.046670195,0.037033193,-0.0058817174,-0.019106537,0.06966747,-0.006554828,0.037378848,-0.043734197,-0.02543187,-0.080753274,-0.056840047,-0.0009941593,0.055558067,-0.05515856,-0.008131924,-0.058713086,0.050694965,0.06242404,-0.064881064,0.022937298,-0.061938975,0.048082,-0.08043904,0.03841074,-0.0042089596,-0.023582073,0.09460812,-0.07977276,-0.08546884,0.018964812,-0.010078831,0.055701558,-0.017073365,-0.0427228,-0.07689067,-0.008104118,-0.022418195,0.0710564,0.018899003,0.047462612,0.046870667,-0.020298462,-0.08836889,-0.049450297,0.023710148,-0.07412795,0.026320266,-0.11846944,-0.027720455,-0.058353785,-0.01337175,-0.07358241,0.022039594,0.024909418,0.030791981,0.007550418,-0.0018775827,0.040150337,-0.044179264,0.026349535,-0.019409236,-0.0066558705,-0.092445716,-0.0013682826,0.053563043,0.028981717,-0.060130846,-0.038123954,-0.12039041,-0.003382971,-0.04723008,-0.0334502,-0.008414653,-0.00592543,0.08937133,0.03337125,0.028004954,-0.009707959,0.0040039765,-0.022520537,0.06159064,0.04263677,-0.03132119,0.05493115,-0.017252516,-0.01626156,-0.026030065,0.021478554,-0.027908187,-0.015806029,0.048838623,-0.025594018,0.104045466,-0.103642195,-0.08379851,-0.06575802,0.007738925,-0.032899383,0.0010812194,-0.06889481,-0.0035580625,0.0025622244,-0.044887234,0.048410174,-0.009656116,-0.028525444,0.06404479,0.099884756,-0.02482588,-0.047313686,-0.040674843,-0.038710803,-0.03206529,0.047569387,0.063339494,-0.04163059,-0.00097140926,-0.046837177,-3.397923e-33,0.0816649,-0.10285143,0.050528213,-0.0037502293,0.032561004,0.019772777,-0.034377232,-0.00057071226,0.08240197,-0.004996551,-0.03541715,-0.052834075,0.0842467,-0.012438781,-0.024046749,0.0028123024,-0.07280127,0.0321428,0.020475812,-0.016830442,-0.05140055,0.054528028,0.00044244417,0.012239194,-0.01883259,0.017012816,-0.030748947,-0.018522728,0.03072325,-0.004992229,-0.018438509,0.02523864,-0.16772847,0.0032719593,0.033813905,0.055099282,-0.017360153,-0.014500523,0.024936153,0.028024463,-0.0058431085,0.0007400596,-0.059508212,-0.035565615,0.08080577,0.054667797,-0.05784751,0.11404018,0.032408573,-0.026368449,0.113607176,-0.08780846,0.10774229,0.030830631,-0.024919637,0.036421742,-0.06805377,-0.03390482,0.012532317,0.11224156,0.03951471,0.017120153,-0.04662234,0.06870782,-0.009480458,-0.013218784,-0.13110746,-0.072738774,0.040442027,0.052414257,-0.05200234,-0.039417293,0.06945164,0.0047960957,0.008258948,-0.0525043,-0.09427308,0.025355618,-0.0051202676,0.11224106,0.072533645,-0.083410986,0.037366953,-0.0047794734,-0.07695149,0.011861429,0.053830262,-0.07828921,-0.02076684,-7.3775875e-05,0.057478126,-0.04620889,-0.040184114,-0.026299266,-0.01845149,9.487625e-35,0.046874035,-0.13713683,-0.06291207,0.048878744,-0.008975294,-0.0085566575,0.03876583,0.0031404719,0.01967253,0.008307972,0.09903247,0.008967161,0.02134868,-0.02335911,0.06680803,-0.028695611,0.008325989,0.06584766,0.01640715,-0.015564955,-0.07196184,0.027878746,-0.009184308,-0.02397307,0.06787209,0.015690148,-0.047412906,0.06646451,0.054885436,0.05682921,-0.015214214,0.022894438,-0.07350473,-0.073877305,0.0033846262,0.023303356,0.005627804,-0.004849148,-0.047319382,-0.06208237,-0.0010669413,0.020522105,0.111104175,0.124184355,0.07730377,0.075736284,-0.03198677,-0.005031284,-0.12492866,-0.05962584,0.05773202,-0.014784433,0.01040908,-1.2869959e-05,0.048625067,0.05823162,-0.021969639,-0.035602868,0.04185093,0.0029436678,-0.033025254,-0.04432966,0.010444689,-0.04715957,-0.020107506,-0.04445946,-0.0200602,0.0043600523,0.06654059,-0.01010773,0.06352856,-0.040023718,0.060947478,0.013395761,-0.030092385,0.012386964,-0.02383533,-0.018753149,0.017381994,-0.05999533,-0.08918843,0.015043752,-0.03198743,-0.021496946,0.015550186,-0.032103583,-0.0019330923,0.07510923,-0.005566434,0.05121494,-0.07545277,-0.03196723,0.01931883,0.053482376,0.04127254,-1.7236024e-08,0.04083241,-0.012588022,0.031605653,0.017202482,-0.02245761,0.049998607,0.0070073796,-0.0013928749,-0.02208188,-0.084952295,0.019131841,0.068817,0.04237259,0.09825976,0.028334668,0.07643717,-0.028233219,0.023189066,-0.026438415,-0.054415308,-0.085450076,0.020461516,-0.073809244,0.024610225,-0.05675557,-0.02144557,0.016391698,0.0680263,-0.03153989,-0.035347097,-0.0071693365,0.01875663,0.060670063,-0.078812756,0.028643865,-0.009071777,-0.019947855,-0.041865297,0.017929805,-0.04132559,-0.012398584,0.020949507,-0.06306639,0.008113569,0.03509656,0.027412863,0.0035511046,0.062560335,-0.030145446,0.038388744,0.061634652,0.00864326,0.0249386,0.03559414,-0.077448115,0.0048352256,-0.019285707,-0.15360793,0.03756046,-0.017659124,-0.012611314,0.050399423,0.10120159,0.012067646 +1.4.1.9,"Also acts on isoleucine, valine, norvaline and norleucine.",384,1.0,-0.011188893,-0.099061914,-0.05006191,0.0054609436,-0.03183259,0.02884787,-0.03582665,-0.024582395,0.09270761,-0.08130447,0.04760527,-0.00023243629,-0.036281098,0.05430864,0.008882847,0.003742162,-0.04472346,0.05541714,-0.00897404,-0.031298388,0.029738778,0.06897778,-0.021284183,-0.026830187,-0.041012447,0.011745094,-0.009446305,-0.0039970083,0.033714708,-0.11448375,0.037333313,-0.03346035,-0.009103029,-0.029429639,0.009437785,0.033602964,-0.07224623,0.050229352,-0.030334733,0.08356525,0.044407357,-0.06280691,-0.035452712,0.0021726473,0.012029265,-0.033061065,-0.030553248,-0.047513966,0.03831784,0.04990891,-0.01324797,-0.07494541,-0.04276524,0.12010826,-0.047502715,0.03167837,-0.12544882,0.0027388704,0.025401816,0.0072293035,-0.013383153,0.04861681,0.021094995,0.011510814,0.04465221,0.056830265,0.06755772,-0.06058273,-0.015503005,-0.10788272,0.022343772,-0.08851464,0.00092474755,0.013835569,-0.03873254,-0.00043676808,-0.03306683,0.009207704,-0.006006999,-0.042739626,-0.090805106,0.058467895,-0.02650208,0.04208666,0.018257955,0.0041586473,-0.021619622,-0.031969592,-0.001724507,0.065839216,0.026456727,-0.031052537,-0.0067529427,-0.00093091594,0.02008128,-0.004521142,-0.0017154032,0.06101028,-0.028290583,-0.036673043,-0.030202463,0.00070301234,-0.18237181,0.0006697323,-0.032859024,0.015896037,-0.0032070077,-0.042833935,-0.05002748,0.0037456618,-0.046315257,-0.024614258,0.032990728,-0.008537079,0.017644111,0.06553542,0.071090624,0.013819214,-0.014146933,-0.024792835,0.007991028,-0.06356755,0.014895586,0.10054425,-0.043264408,0.093366385,-0.029660806,1.0464504e-33,0.065285824,0.0036646621,0.07273229,0.020429127,-0.019804401,0.002106959,-0.041257884,0.0118864,0.04906317,-0.12728441,-0.03445115,-0.0339525,0.08186331,0.03365822,-0.021062242,-0.037020925,-0.00075214193,-0.02704967,0.040761076,-0.08034249,-0.023058308,0.13474554,-0.031553075,0.03151595,-0.05302139,0.011500281,-0.019539757,-0.005159403,-0.013712523,-0.030377338,0.023348805,-0.076374434,0.022470422,0.054113913,0.04568104,0.13136001,-0.02530644,0.046874624,-0.029838035,0.069150746,0.014234245,0.016758207,-0.056728348,-0.018611873,0.09063432,-0.07304665,-0.07580616,0.10290646,-0.0062656235,0.0008408765,0.07075054,-0.024296556,0.06736581,-0.033400893,-0.027824465,0.06415878,-0.043568235,-0.023659758,-0.054658078,0.06738471,0.029810296,0.06843089,0.05517014,-0.0067805205,-0.02108709,0.017202169,-0.13924956,-0.07984795,-0.032038722,0.00033308653,-0.10393168,0.048140008,0.09546494,0.05036057,0.016231906,0.01489864,-0.09323721,0.00081155705,0.030544307,-0.02646722,-0.042053156,-0.08086612,0.06528956,0.018483449,0.018889707,-0.044093326,0.029511776,-0.075586714,-0.011967787,0.00969496,0.052756637,0.014845617,-0.052115798,-0.0635678,0.048173033,-2.8949287e-33,0.061317384,-0.10285982,-0.011147543,0.011777711,-0.012274885,0.027230226,-0.050933257,-0.020358568,0.037270647,0.0097083235,0.0367752,-0.038740378,-0.017134208,-0.07998717,-0.00603042,-0.042723894,0.016383318,0.10008927,-0.029126365,0.01646151,-0.08797927,0.058835994,-0.03460629,0.075260006,0.03534858,0.051762626,-0.0017192664,-0.017958885,0.019585341,0.06413898,0.012416439,0.01995321,-0.056880996,-0.08642713,0.027150529,0.05371065,0.013789774,-0.022293424,-0.033391643,-0.13599223,-0.035662655,-0.00084579247,0.061829425,0.060104687,-0.0007332974,0.03714516,0.033545878,-0.0012087375,-0.14061351,-0.032376472,0.017769195,-0.04928435,-0.021066623,0.07579097,0.07053767,0.0723681,-0.004988407,-0.064748324,0.04458459,-0.044384267,0.025615828,0.015389456,-0.01532187,-0.07679204,0.067669965,-0.04075772,-0.027372815,0.05103508,0.039746977,-0.02863149,0.058117624,-0.03634706,-0.011910859,-0.009536801,-0.089455076,-0.04616982,0.051173832,-0.08651252,0.0063341577,-0.06436178,-0.07433747,0.010716722,-0.029484196,-0.06277567,-0.029521458,0.03527834,0.026858104,0.088490784,-0.0055650375,0.06900425,-0.02620545,0.007814037,-0.050749242,0.023912732,0.071894646,-2.4216211e-08,0.07980661,0.000763573,0.026269598,0.0063707703,-0.056208134,-0.013089838,0.09918386,0.0037876344,-0.023711877,-0.005135324,0.030000221,0.09268809,0.06458738,-0.054168344,0.06740437,0.028185239,0.038208734,0.06472095,-0.03607678,0.006292955,-0.0662554,-0.021043986,-0.049690735,-0.027208544,0.0062181223,-0.08829537,0.07983278,0.06527037,0.09109909,-0.047693543,0.0794504,-0.04407009,0.058841508,-0.12120634,0.0029567752,0.061944198,0.08184305,-0.027308267,0.050617915,0.019597972,-0.038384773,-0.044032406,-0.058138907,0.024290562,0.05015744,-0.010261098,-0.02939741,0.01766029,-0.010945416,0.025094748,-0.0057861977,0.010785359,0.03871087,-0.00532679,-0.062706135,0.0673242,0.015950983,-0.050279368,0.055811662,-0.038519915,0.021785775,-0.004327904,0.13295962,0.043665674 +1.4.1.12,"Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].",384,0.99999994,-0.0055472464,-0.06403607,-0.0016441278,-0.050593324,0.06247505,0.016816113,-0.05807453,0.021100089,0.0070632887,0.034299273,0.0016062179,-0.0040253834,-0.11126293,0.059099354,-0.019079806,0.10044656,-0.0344953,0.022429792,0.012151856,-0.05381657,0.036640648,-0.009453171,0.030076798,-0.00040565888,0.056696128,0.060431603,0.010061359,0.07532616,0.006042872,-0.08885404,-0.039858237,0.00203523,-0.018427681,-0.04696268,0.005975839,0.08974174,-0.043840088,0.008424002,0.0060698627,0.00027833693,0.050688315,-0.016753923,-0.06618905,0.028753765,-0.046013616,-0.06727203,0.03479981,0.048461914,0.026234657,-0.012058017,-0.017485814,-0.023978822,-0.0164858,-0.008779462,0.013709333,-0.014294391,-0.0042483723,0.048702687,-0.06874367,-0.060221527,0.0049416698,-0.022229077,-0.042925987,-0.025344476,0.03952675,-0.02719274,0.07033176,-0.074097775,0.0050016916,-0.037502415,-0.0650157,-0.022530435,0.026780844,0.03577711,-0.047396522,-0.027863348,-0.11376294,-0.047887236,0.07890296,-0.023416989,0.047954675,0.05324564,0.003594895,0.0034811893,0.032328144,0.039321955,-0.003926108,-0.0011195951,-0.018652804,-0.02620636,0.012313057,0.036180235,-0.079017796,0.039284118,-0.07964798,-0.009821621,0.053493753,0.081688814,-0.012122272,-0.032359898,0.0313423,0.10437898,-0.060404304,-0.06457097,-0.0115527185,-0.016931983,0.004394533,0.08456884,-0.07084256,-0.007792045,-0.0048792763,-0.032811366,0.03302566,0.020121053,-0.053245734,0.13654298,0.0012222922,-0.0028634695,-0.09114685,-0.044698194,0.025954371,-0.0021833929,0.057533614,0.066048615,-0.056455866,-0.0058544506,-0.057809018,1.581169e-33,0.05823675,-0.046747964,0.008524103,0.10178593,0.044876765,0.0046671615,-0.09161553,0.02402993,-0.010697214,0.009219779,-0.035949413,-0.034147643,0.079046555,-0.021238793,-0.033451803,-0.047506273,-0.06715317,0.013532465,-0.0023457601,-0.022342255,0.04591075,0.13039534,-0.029747438,0.045141064,0.030823488,0.015942076,-0.020262286,0.035270847,0.06180899,0.0008965491,0.012766611,-0.13499825,-0.0998624,-0.044506393,0.093730934,-0.026772847,-0.015080277,-0.03432859,0.037282962,0.06568094,-0.09906464,-0.015628364,-0.048459426,-0.07374917,0.025971543,-0.10561649,-0.013356,0.12377936,0.005967562,0.03394973,0.07446666,-0.04481613,0.07622464,-0.04531561,-0.053018518,0.032101166,-0.012702447,-0.016175065,0.019305907,0.11132152,0.050150704,0.009345558,-0.04445499,0.005451248,-0.023889786,0.013106253,-0.0689137,-0.06343901,0.031279236,0.09903879,-0.0027641633,0.02000525,0.092499845,0.04239628,0.054528542,-0.03291526,0.029771125,0.019879172,0.01596997,0.018976104,-0.0045608766,-0.052527618,-0.019241268,-0.014232289,-0.03418561,0.06628633,-0.0059246533,-0.06072243,-0.027401749,0.07096938,0.0010602176,-0.08356759,-0.018077224,-0.015279243,0.06937795,-2.2529956e-33,0.08011187,-0.08318303,-0.012315205,-0.056466386,-0.017877176,0.11202635,0.016011132,-0.051788963,-0.015219297,-0.031004386,0.08295372,0.07961345,0.007819507,0.039096653,0.028908493,-0.028052082,-0.027570026,0.10775598,-0.013241002,0.039809965,0.074533544,0.07713889,0.010207026,0.053847566,0.0982173,0.01194221,-0.057974678,0.02162975,0.06911803,0.051272348,-0.049857337,-0.005386688,-0.05803814,-0.045614474,-0.024470884,0.07234465,-0.0410547,-0.0062934803,-0.06642471,0.08410644,-0.09447122,0.0161348,-0.038832057,0.028086687,0.032926664,0.011959982,-0.123530895,0.0021564236,0.008178379,-0.07012945,0.031409476,0.054524355,-0.08102836,0.043337326,0.045268033,0.015462789,0.0052658347,0.0052663893,0.07258787,0.035474237,-0.033110283,-0.07555824,0.0063185594,-0.035988335,0.053716578,0.014566342,-0.011736665,0.017472466,0.054906663,0.020239305,0.06610028,0.0022023737,0.007691232,0.059114408,-0.05400649,-0.017874178,0.03221655,-0.047722813,-0.016593318,-0.047887363,-0.031059595,-0.020393737,0.002074215,-0.07597294,-0.08036568,-0.042089663,0.03433571,0.109286375,-0.030520298,0.07640131,0.019939581,0.01726758,-0.06242352,0.07910201,-0.027865695,-4.288124e-08,0.03461973,-0.025544295,0.07548905,-0.040736984,-0.00081866013,0.036739092,0.030394867,0.0065539214,0.062496495,-0.050799187,0.056865875,0.08348512,0.044708245,0.04173844,0.026750231,0.02752916,-0.0256597,0.033161692,-0.026124781,-0.034213282,-0.08467832,-0.010799813,-0.100505866,0.004704836,-0.008913123,-0.06574226,-0.0015449878,0.04653468,0.009220138,-0.039236203,0.016072288,0.03986765,0.060787067,-0.04365301,-0.05708688,0.077913366,-0.06732174,0.065425865,-0.117064744,0.009183625,-0.035743337,-0.09591813,-0.013369752,0.022659862,0.03809031,0.008340418,0.028182803,-0.04852558,-0.029692829,0.015369673,0.09367247,-0.020189725,0.024741912,-0.038808987,-0.12116077,0.06726944,-0.047975935,-0.084040746,-0.0044764946,-0.063742414,-0.057291776,0.007852548,0.14219715,-0.0116273835 +1.4.1.13,"Binds FMN, FAD, 2 [4Fe-4S] clusters and 1 [3Fe-4S] cluster. The reaction takes place in the direction of L-glutamate production. The protein is composed of two subunits, alpha and beta. The alpha subunit is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.4, glutamate dehydrogenase [NADP+]). The beta subunit transfers electrons from the cosubstrate. The NH3 is channeled within the alpha subunit through a 31 A channel. The chanelling is very efficient and in the intact alpha-beta complex ammonia is produced only within the complex. In the absence of the beta subunit, coupling between the two domains of the alpha subunit is compromised and some ammonium can leak. ",384,1.0,0.0045093964,-0.08291328,-0.07153814,-0.07488787,0.061470043,0.018640282,0.0059118057,0.022580435,0.013949985,-0.026666367,0.018969936,-0.061458975,-0.051202472,0.05305064,-0.06403144,-0.030973505,-0.099627316,-0.05933899,-0.07413563,-0.059889685,0.032789122,0.06809358,-0.030329416,-0.09232155,-0.0011619154,0.08521397,0.06601454,-0.06617673,0.062155366,-0.0903554,0.0055471985,-0.054042377,0.01983882,0.002324425,-0.014284252,0.06431234,-0.01446132,-0.058921535,0.07557793,0.031627856,0.0037113687,0.0749865,0.026893187,-0.094525866,-0.014585666,0.058226902,0.03982046,-0.008274545,0.004298265,-0.03648672,0.051778726,-0.03261251,0.008273038,0.115999416,-0.0074655386,0.050488003,-0.08288744,0.023623154,-0.070036486,0.10881551,-0.00284465,0.035642028,0.021694805,-0.043160234,0.1325451,0.00023654256,0.014765651,-0.07866257,0.01121101,-0.050506454,-0.03897898,-0.016575232,0.017050182,-0.049833007,-0.006781554,0.048200306,0.05046178,0.035000954,0.038920533,-0.04961653,0.055265527,0.025063744,0.10711025,0.046242535,0.023106707,-0.04737084,-0.04390203,-0.019841796,0.032255396,0.052515205,-0.0511302,0.01506584,-0.01791524,-0.008231442,-0.050454747,0.046584032,0.059998825,0.034961533,0.032915954,0.026978258,0.004776331,0.13470021,-0.0186048,-0.051295623,-0.057336446,-0.021437328,0.021947905,0.12723118,-0.025322946,0.044831004,0.03280933,0.07727397,0.06535907,-0.03281489,-0.03228012,0.015987834,0.01241609,-0.031126436,-0.03636229,0.004702631,0.009020373,-0.008295373,0.01240657,0.07310573,0.006405544,-0.0031186428,-0.1666614,3.050353e-33,0.05489029,0.008680682,-0.0617676,-0.01603344,-0.018638602,-0.02389526,-0.062346075,-0.031211521,0.046095077,0.008058219,-0.079489544,-0.024350217,0.016463196,-0.06271115,-0.021131007,-0.03430509,-0.055335503,-0.027201835,0.011540754,-0.020416925,0.045942537,0.053837202,-0.037286986,-0.004860274,0.008234774,0.041890983,-0.03068087,0.03946452,0.0086820815,0.0045244386,-0.0054822112,-0.07955915,-0.1346154,-0.0013897992,0.020488745,-0.020981524,-0.08633541,-0.05687262,0.0051394897,0.032752573,0.0058350274,0.047911637,-0.05462113,-0.014353718,0.0594231,-0.013310342,-0.024681477,0.041766416,0.020834625,0.052717526,0.026216822,-0.0887736,0.054668132,-0.019228712,-0.0299425,-0.027602296,-0.05574915,-0.04281014,0.060152415,0.08599975,-0.012566477,0.029943872,-0.06925524,0.06449487,0.030594885,0.059414748,-0.014827843,-0.08852408,0.08673399,0.019883463,-0.030222293,-0.035728592,0.11287582,0.0066923997,-0.05351611,-0.033628765,-0.009924406,0.012255546,0.007839539,0.028621692,0.051682968,-0.009679896,-0.012911451,-0.017228898,-0.011531757,-0.055429846,0.05926368,-0.07998643,-0.040545013,0.012587065,0.040930573,-0.007357485,0.053287245,0.0018395832,0.017677898,-3.1286058e-33,0.070923425,-0.063652396,0.0073920004,-0.093998305,-0.07259687,0.06596892,0.0005432377,-0.056998324,-0.024141029,0.0069236984,0.028297594,0.015021991,0.013591273,-0.006081174,-0.014821187,-0.035215475,0.011433345,0.051871244,0.04476445,0.015807737,0.05590669,0.08197681,0.051389802,0.09680326,0.04802027,-0.0043491516,0.05208854,0.024142172,0.0029188788,0.06489237,-0.011439899,-0.0086005945,-0.04561244,-0.06974136,-0.014640366,-0.06664292,0.013717825,-0.0397349,0.004489029,-0.04981099,0.054216057,0.07850647,0.02226474,0.045537036,-0.0117612975,0.11014104,-0.030605294,-0.0442088,-0.024950916,0.006015589,0.009400321,-0.04878824,-0.07385451,-0.052525513,-0.013305652,0.022676589,0.053187575,0.016741773,0.035324935,0.024047704,-0.02037767,-0.14167073,0.033853877,-0.036142424,0.022671089,-0.015445983,0.072979406,0.06666641,0.072244346,0.089028426,-0.012267051,-0.03593417,0.1364602,0.037822835,-0.004301438,-0.005760915,-0.013463161,-0.03335725,0.024145572,-0.08367416,0.012532058,0.024423806,-0.042751785,-0.048066676,0.07088334,-0.054825634,0.056993857,0.18733598,-0.0185212,-0.0045948294,0.04103594,0.033359077,-0.009586685,0.026181743,0.061666705,-4.933137e-08,0.040931933,-0.045243803,-0.0008433542,0.001912881,-0.010557998,0.11995752,-0.010602959,-0.0118808765,0.019642204,-0.03508244,0.026600026,0.103162564,-0.07266465,-0.011385212,0.008210829,-0.034066934,-0.091436066,0.0255996,-0.037324622,-0.054624274,-0.03947226,-0.007447935,-0.08219677,0.042252928,0.033209722,-0.08408957,0.0045163953,0.026772598,-0.015559795,-0.05018031,-0.01589719,0.0793644,0.060708586,-0.06895549,-0.13265078,-0.046467993,0.022961691,0.02295401,-0.0865864,0.011305368,-0.00955689,0.0018467214,0.014426238,0.0035960313,-0.039448682,0.060169812,0.026589066,0.033547625,-0.031502616,-0.020996612,0.050231818,-0.044470225,0.051133,-0.014257236,-0.11087285,-0.046898186,-0.1098555,-0.031069199,0.036407657,-0.03416903,-0.04265961,0.036901053,0.026200335,-0.034506235 +1.4.1.14,"A flavoprotein (FMN). The reaction takes place in the direction of L-glutamate production. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.2, glutamate dehydrogenase). ",384,0.99999994,-0.06151887,-0.10020125,-0.10550771,0.010457029,0.06344208,0.027032403,0.015537333,0.04093758,0.052081693,-0.057548024,0.043863185,-0.018842272,-0.05678371,7.1519644e-05,-0.078361474,0.016063383,-0.07129587,-0.054747436,-0.08450368,-0.016731994,0.059185583,0.080987595,-0.006050869,-0.050054908,-0.028654316,0.025498988,0.027624344,-0.043111477,0.028419603,-0.053396355,0.10140299,0.011544314,0.0505314,0.030007197,-0.05339098,0.04311603,-0.026599243,-0.06730278,0.052892804,-0.007838467,0.026332714,0.015640765,0.03281602,-0.12022854,0.057626948,0.01371793,0.0026598438,0.052104134,0.022167925,0.054063108,-0.008972954,-0.04773625,-0.08482889,0.08301724,0.030458476,0.05476495,-0.08709252,-0.028384484,-0.06134541,0.091635145,-0.0122192195,0.06517124,0.0047011045,-0.034758847,0.1532132,-0.08822202,-0.00731654,-0.05278877,0.052954186,-0.026269251,-0.018918151,-0.032107502,-0.023743933,-0.014250966,0.006647862,0.04447868,0.0006984179,0.071045876,0.028782409,-0.031744108,0.119809866,0.00046181033,0.051774006,0.08990347,-0.005653186,-0.078772694,-0.09370298,0.04884108,0.038852837,0.07558698,-0.0658051,0.01658758,0.015367747,-0.011036745,-0.04592199,0.06839276,0.025137508,0.005187045,0.008338732,0.040749528,-0.029521229,-0.0023650562,0.0364721,-0.05659868,-0.030590884,-0.022687184,-0.029389752,0.054780316,0.027448874,-0.038661197,0.024349919,0.02315638,0.035959113,-0.07644549,-0.020288419,0.0047137225,-0.0057218126,-0.046548836,-0.017581321,0.0023498186,-0.015080226,0.06103172,0.022675363,0.07665227,0.025176926,0.020661552,-0.1383667,2.2840662e-33,0.05012298,-0.018788889,0.0073408308,-0.013766842,-0.0058199307,-0.011369892,0.014711198,-0.022275906,0.06042846,-0.010053962,-0.09606074,0.0024130882,0.01487783,-0.0044352454,-0.012386212,-0.03820068,-0.056873187,-0.01269929,0.025474524,-0.011883772,0.017804185,0.04549729,-0.028096702,0.016712718,0.018305624,0.038113534,-0.03845332,-0.03650245,-0.026461039,-0.0052985055,-0.03223403,-0.056461174,-0.07457325,-0.00092079607,0.056602478,-0.011505822,-0.067327194,-0.07595756,-0.03852644,0.08740344,-0.006237766,-0.019791737,-0.089670755,0.023487132,0.019754814,0.036469135,-0.097754605,0.089411706,0.023387806,0.08085171,0.059316244,-0.06874346,0.101148345,0.009717495,-0.043457195,0.030150611,-0.030620143,-0.009754347,0.046964925,0.048271973,-0.04602174,0.04239448,-0.07986822,0.031061823,-0.009739538,0.006220352,-0.016270919,-0.064061396,0.083086796,0.03268714,0.0029478788,-0.028435875,0.08260102,0.032601498,0.0176455,-0.023558622,-0.08378028,-0.014739213,-0.015486319,0.0601302,-0.007415709,0.0053400607,-0.03420228,-0.015566746,-0.060209826,0.009480655,-0.002917308,-0.0804833,-0.012652659,-0.008415171,-0.0051135453,-0.013726735,0.03419816,-0.005938937,0.053778566,-2.9392557e-33,0.028965594,-0.100900695,-0.09126984,0.020545397,-0.012056761,0.016962737,-0.014031527,-0.043757807,-0.017953394,0.061627295,-0.009391636,-0.07631355,0.012098497,-0.017636903,0.01158134,0.008680625,-0.013963433,0.0841397,0.033285707,0.014473335,-0.032444,0.024612501,0.05366253,0.10749429,0.049472895,0.002193342,0.04147111,-0.006069183,0.010813588,0.084420405,-0.07322563,-0.04196921,-0.01608725,-0.07207596,0.016579168,0.014528802,0.005167141,-0.03688455,0.015144959,0.008521611,0.026640432,0.047940597,0.07546611,0.073642604,0.003791639,0.08401161,-0.03927984,0.015567367,0.013040055,-0.028294003,0.03685996,0.024527378,-0.020071005,0.02613446,-0.010542082,0.025838405,0.063611746,0.009667872,0.014572382,0.029290562,-0.047962748,-0.16136275,0.013866844,-0.044226117,0.053764753,0.07001516,0.08104437,0.081683904,0.030489808,0.00058692216,0.09138553,-0.047742847,0.12260726,0.06611546,0.021749368,-0.031595115,-0.01889829,0.011841721,0.010132408,-0.05624413,0.056903563,-0.03500346,0.032646753,-0.05586152,-0.0069190077,-0.09620646,0.008453449,0.109649114,0.036014426,0.012791958,0.023847723,0.025957275,-0.07687783,-0.03910578,0.026185712,-4.195957e-08,0.022905773,-0.12508042,-0.0035244306,0.01626939,0.061842516,0.1051274,0.0073316637,0.0038495099,0.0056632254,-0.019187395,-0.005222332,0.102644354,-0.09089701,-0.035166934,0.019788444,-0.040720087,-0.01428409,0.07967109,-0.036930088,-0.050185967,-0.054036107,0.038330548,-0.08573553,-0.014350217,-0.0018483455,-0.060695495,-0.016911305,0.029733721,0.08182681,-0.034919597,0.016174998,0.087409325,0.0054919217,-0.061015513,-0.17018147,-0.05728154,0.03253196,-0.026564175,-0.04739826,-0.008848143,-0.1188102,0.064918876,-0.014872853,-0.032959644,-0.011781501,-0.007942613,0.04935117,0.02876305,-0.016026042,-0.03791638,0.0034451035,-0.021205107,0.018607566,0.023523804,-0.10441506,-0.051966917,-0.05140716,-0.0647593,0.022274164,-0.061715405,-0.048176788,0.08389319,0.122939765,0.05159071 +1.4.1.18,"The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4].",384,1.0,-0.048227377,-0.13579969,-0.05648958,-0.033466794,0.109909326,0.0711211,-0.12395063,0.080287024,-0.0128478035,-0.0045988685,-0.0007980875,-0.003560854,-0.037277173,0.06661535,0.020040886,0.0457892,-0.010639167,-0.024662806,0.047049046,-0.023110988,0.051747758,0.024007667,-0.06549176,-0.061554346,0.11650992,-0.06790165,-0.018429307,-0.023338703,-0.037931304,-0.039368328,-0.0067389854,-0.03348577,0.025907237,-0.07804628,0.023339469,0.053781897,-0.12232038,-0.026124774,0.08402568,3.581971e-05,0.007127258,-0.002838057,-0.044585373,-0.0098991245,-0.075803146,-0.033742856,0.031178214,0.041563217,-0.018815126,0.00031646746,-0.015548707,-0.034546707,-0.017875835,0.0083927,-0.08654359,-0.05794625,-0.0483231,-0.016466985,-0.0092304265,-0.039066862,0.014038804,-0.0073288013,-0.022077367,0.011445809,0.050948367,-0.06049716,0.056336094,-0.08865789,0.011331806,-0.022688827,-0.07808625,-0.019791268,-0.010470455,0.10659736,0.031850558,0.050064735,-0.035741,-0.0024649277,0.06511844,0.0015829178,0.012928388,0.029631915,-0.05102597,0.07897545,0.05451311,-0.006371473,-0.0033862211,0.084780134,0.01834223,-0.040645827,0.074319914,0.017688815,-0.03819559,-0.0014167206,-0.108346015,-0.04055556,-0.0032756785,-0.00011493142,-0.018776115,-0.05023437,0.04828298,0.07650574,-0.027337112,-0.009405944,-0.0460104,-0.029486312,-0.0074287355,0.07666713,-0.057136096,-0.042579178,0.020906864,0.0046232413,0.0712802,-0.055326797,-0.031231739,0.042309374,0.026721645,-0.06540852,-0.09644676,-0.022874054,0.025301663,-0.017842676,0.060125265,0.04346846,-0.0010587305,0.07877746,-0.09137001,3.51591e-33,0.08654352,0.0052541695,0.018700937,-0.0522389,0.04704112,0.037183493,-0.0987365,0.079756126,-0.0017692248,-0.03001318,-0.08926718,-0.06069616,0.061006833,0.036039673,-0.018793171,0.101887144,-0.017326958,-0.07520569,0.04764125,0.07746378,-0.0029022475,0.041709665,0.018587744,0.08773827,0.04524696,0.01570585,0.040592406,0.048357416,-0.027908951,0.016788607,-0.005266933,-0.15731654,-0.08761305,0.015104254,0.081609435,-0.019320248,-0.04305689,-0.06500223,0.03605024,-0.0068802405,0.0050853873,0.1041666,0.065525934,0.0067985896,0.031153275,-0.008169158,-0.055781625,0.08041995,-0.042367082,0.02953303,0.107612066,-0.05719635,0.040856764,-0.060108423,0.02326857,0.078045666,-0.03245549,0.0854603,0.001042459,0.07009733,0.05297632,0.0773987,0.016167076,0.07078185,-0.059595432,0.04077348,-0.054489728,-0.056720007,-0.0006171794,0.043485653,-0.021069787,0.036771093,0.045212477,0.04981087,0.04766491,-0.080558375,0.00793136,-0.013067791,0.076204166,0.0057823993,0.023603035,-0.052569494,-0.03751869,-0.015453847,-0.05094281,-0.07708441,0.0132509,-0.0142996255,0.006669342,0.017273054,0.024037072,-0.07478391,0.02197128,0.019874264,-0.030649364,-4.0265446e-33,0.05011791,-0.07871939,0.088180356,-0.09135277,-0.022461956,0.05139241,0.059432983,-0.07769458,0.027667379,-0.01798214,0.065596856,0.067795776,0.028352484,0.026705053,0.06489797,0.022974104,-0.012116206,-0.004298442,-0.020422636,-0.022243407,-0.065608025,0.07030866,0.09228505,-0.064735524,0.08523618,-0.046291005,-0.090494774,0.09662723,0.022331784,0.011607383,0.010443123,0.02677421,-4.7926434e-05,-0.10398002,-0.07304327,0.0821266,0.010669546,-0.062436268,0.034044307,0.00777878,0.036485087,0.00045464022,-0.0123777585,0.03455772,-0.007899689,-0.0068631624,-0.09032425,-0.09139321,0.019055683,-0.06114731,0.02840028,-0.010827054,-0.035137422,-0.03190335,0.041801322,0.05916216,-0.026900876,0.034077335,-0.066889994,-0.015121591,-0.026498824,-0.053733908,-0.013476929,0.022347152,0.04278575,0.06109357,-0.013705406,0.07782421,0.008185189,-0.017628824,0.08680122,0.010240246,0.03756029,0.07291825,-0.03563416,0.0027445257,-0.04980563,0.024564233,-0.016318612,-0.0062373006,-0.024873653,-0.028799174,-0.010744412,-0.016377239,-0.0017189209,-0.044790927,-0.0016646013,0.08844519,-0.013281941,0.026724067,-0.014039289,0.0010463172,0.016782947,0.07074244,0.108892985,-3.7756447e-08,0.060315255,-0.04644742,0.022718411,-0.0807209,-0.04612184,0.032647986,0.004563608,-0.033824194,0.006834915,-0.00039608346,-0.017924018,0.13950147,-0.017386468,0.009371007,0.047356974,0.020196673,-0.033103116,0.0029946633,-0.030606415,0.014841445,-0.018577587,0.023654057,-0.11042658,0.012033019,-0.021639708,-0.045324337,0.00038700376,-0.052740093,0.028363215,-0.05192715,-0.0124805765,-0.01131356,0.0032288805,-0.042827964,-0.07985874,0.0064680898,-0.085304864,-0.050497375,0.032156494,0.07681301,0.01735958,0.0026741843,-0.09474846,0.03475378,0.0014666108,-0.009427948,0.009283394,-0.014189252,-0.030016266,0.015324377,0.004988638,-0.05022385,-0.014263559,-0.05252936,-0.0052017653,0.013081837,-0.026056908,-0.040892266,-0.03452243,-0.0674163,-0.046752684,0.03357619,0.18261859,-0.014054328 +1.4.1.19,Activated by Ca2+.,384,0.99999994,-0.05304563,-0.0002820681,-0.021134285,0.07623617,0.026732536,-0.011337265,0.09874507,0.07023802,0.078159556,0.03287204,0.08410986,-0.040694315,0.038716428,0.05782158,-0.03291351,-0.0068778093,-0.008397657,0.017815348,-0.018045869,-0.091534905,0.06500268,-0.01898964,-0.041772768,-0.00051757554,0.004993538,0.0674742,-0.07124228,-0.008773828,0.07577091,-0.023497975,-0.05676444,0.049780257,0.04076295,-0.05430383,-0.07418649,0.021972053,-0.043489046,-0.047336623,-0.06620597,-0.05736061,0.06660082,-0.063564315,-0.027332904,0.039193206,0.019165149,0.001181762,0.021155627,0.0313545,0.036813203,0.02199111,0.008269191,-0.0036586297,-0.036304638,0.07993308,-0.02006712,0.030602384,-0.08252427,0.06619174,0.05933007,-0.048241436,0.0012446298,-0.04839687,-0.0062941345,0.043008685,0.06854467,0.002296676,-0.042244542,-0.08944424,0.055825338,-0.014902461,-0.027349494,-0.019428998,0.049622245,-0.024322158,0.086028606,-0.044501558,-0.044228178,-0.07241863,0.0793333,-0.0033746273,0.043994404,-0.016931074,0.011383858,0.07153009,0.07175546,0.086319156,0.026851475,0.0148059605,-0.041323945,0.0015809158,0.046958722,0.023941291,0.020459747,-0.0041316166,-0.07918886,-0.010616644,-0.024342334,-0.062920354,-0.055788267,0.020169577,0.03612862,0.077643365,-0.13043213,-0.080577046,-0.030732775,-0.033721045,-0.021667566,0.025022095,-0.007341528,0.05868404,0.061587807,-0.002828379,0.01590863,0.0039542643,-0.024937913,0.20249797,-0.0039225323,-0.023017325,-0.010661217,-0.081458524,-0.003689888,-0.07381729,-0.09457823,-0.088159814,-0.08208432,-0.022703454,-0.0073212986,-2.677465e-33,0.013286688,0.017139018,0.010149794,0.034131918,0.029787961,-0.019081486,-0.027246848,-0.038626656,0.008729412,-0.036282156,-0.017934904,-0.03154871,-0.043436874,0.08437111,0.016691837,-0.0479416,-0.030657707,-0.069224596,0.12837298,-0.0049704043,0.060548335,0.05176873,-0.015336219,0.048792742,0.04703831,0.1086914,-0.020359928,6.431658e-05,-0.0043585273,0.018121459,0.065166235,0.0005146349,-0.10532744,0.03270957,0.016931226,0.08422958,0.024517233,-0.012490082,0.023380361,0.062554516,0.022869926,0.014037352,0.01517175,7.4912e-05,0.04002581,-0.09514034,-0.05311177,0.010048856,0.10117595,0.09887861,0.023302786,-0.028445672,0.007396551,-0.034704223,-0.042280164,0.021074075,-0.027440082,-0.0354482,-0.09763542,0.0030368376,0.015838383,-0.0022139568,0.0078053726,0.058112375,-0.037584297,0.038016744,-0.032233622,-0.04368186,-0.02257243,0.044647902,-0.055223633,0.00747978,0.11188636,-0.010539345,-0.030526938,0.02218818,-0.04058502,0.08939652,0.0024025985,0.03130563,-0.045336243,-0.074535616,0.011100054,0.074616194,-0.019133557,0.0075848717,-0.055363595,-0.039359167,-0.027229138,-0.00019349043,0.026780458,-0.04073626,0.03331222,0.0067960983,-0.084878825,1.7172106e-33,0.0067177494,-0.051726207,0.020034198,0.014507424,-0.006954936,0.027231926,-0.009444197,-0.08811129,0.013044357,0.04068067,0.051525097,0.07940103,0.020255249,0.021376725,0.055964343,0.046973977,0.012193214,0.0842282,-0.081238955,-0.0138566205,-0.023219379,0.04772169,0.03370766,0.062265795,0.08034474,0.032338083,0.061348557,0.027984995,0.055057757,0.032169342,-0.035959985,-0.006502489,-0.101516254,0.0031526724,-0.083891265,-0.0024539677,0.051828414,-0.0037432902,-0.069236115,0.00818467,0.014531416,-0.037554123,-0.0026322643,0.14647831,-0.0020551598,0.025814652,0.07997473,0.011633974,-0.107286535,0.029909348,0.03878172,-0.03460759,-0.031711496,0.028967833,-0.00246498,0.08469155,0.06330165,0.048356034,-0.029050605,0.014153321,0.043094642,0.026077515,-0.04269537,-0.12230337,0.019616725,0.020942735,-0.016734188,0.05568619,0.051469047,-0.08542823,0.13982786,0.04821905,0.028527452,-0.06286049,-0.100297354,-0.07241051,-0.08720776,-0.046369996,-0.0029919122,-0.07347373,-0.06642113,-0.01692949,-0.0032985387,-0.040506475,0.0059433444,-0.036846288,-0.045389008,0.044714727,-0.020925803,0.04242282,-0.10092387,0.033325475,-0.05413903,0.018449698,0.022196852,-1.4847335e-08,-0.03326471,-0.02309229,-0.04534116,-0.04865388,-0.004317002,0.05801531,0.029063594,0.05556025,-0.003731717,-0.06784918,-0.005238222,0.014501378,0.03414052,0.024314236,0.071381494,0.054619458,0.02808607,0.032096338,-0.0922773,-0.08031738,-0.085206255,-0.062330272,-0.0363614,0.05137344,-0.029775875,-0.011767789,0.043487985,0.08608621,0.02900763,0.007015845,0.004771879,-0.01880775,-0.015657002,-0.07347045,0.009478643,0.06937481,0.03325572,-0.04369582,-0.01107745,-0.033011023,-0.043053027,0.0045310124,-0.033615842,0.043845005,-0.05915394,0.0033844276,-0.011837889,-0.0064474833,0.01062506,-0.017685167,0.06284161,-0.060577907,0.021701567,-0.038978785,-0.16069302,0.046697654,0.023551796,-0.028686509,0.036527235,0.015896205,0.055817455,0.021690292,0.10207563,-0.064806 +1.4.1.20,The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine.,384,1.0,-0.035424083,-0.11399568,-0.013997341,-0.06601705,0.0621839,0.087912284,-0.08213485,0.020685038,0.017626286,0.02626295,0.06820628,-0.050506413,-0.018468209,0.11895864,-0.037729535,0.06930513,-0.13275519,0.032656856,-0.011637992,-0.025235185,0.109106734,0.06966025,-0.028809857,-0.00034336958,0.009806153,-0.11444875,0.055594873,-0.077658445,-0.051573474,-0.025096957,-0.038309813,-0.035468146,0.039135717,-0.086731665,0.033644706,0.03140015,-0.055728793,-0.028169762,0.10456808,0.028547244,-0.025327286,-0.05821132,-0.010241289,-0.08013366,-0.0750756,0.02504735,0.028883608,0.03287424,-0.023186756,0.04311056,-0.06701066,-0.0040144296,0.005359738,-0.011993192,-0.050559945,0.004136256,-0.06788174,0.077533245,0.041411523,0.016535837,0.012383079,0.029501308,0.04649015,-0.017498687,-0.048180524,-0.017829163,-0.02428736,-0.051126458,0.0018752026,-0.06943507,-0.033574637,-0.08151585,0.016816996,0.013268194,0.0227027,0.04846844,-0.040646292,0.015460723,-0.058109738,-0.088699184,0.04303926,-0.044180114,-0.029970484,0.06953878,0.04925388,-0.014883769,-0.008477957,0.03551497,0.10702324,-0.02062694,0.10466411,-0.01802851,0.006203693,-0.03711057,-0.010642727,-0.012782904,-0.009903137,-0.0012635071,-0.022739217,-0.020168187,-0.0647202,-0.0070428797,-0.06831779,-0.06298581,-0.005426322,-0.04419935,0.024913503,0.0647076,0.010279331,-0.043774173,0.09984392,0.02786121,0.09726657,-0.03060299,-0.038392387,0.0043220697,0.034897543,-0.08004953,-0.09201747,-0.038755152,-0.024569398,-0.011183504,0.054441296,0.07342341,-0.025202729,0.07192657,-0.0749645,4.3431232e-33,0.10973541,0.0021651674,0.033904854,-0.010916616,-0.0133051025,-0.04783884,-0.053346477,0.041822914,0.041788545,-0.11109083,-0.085127115,-0.07452419,-0.006802788,0.022369593,-0.07309577,0.07233313,0.0030235965,-0.03276754,0.03537908,0.02519874,0.031169204,0.061409965,0.002036568,-0.011951563,0.04789049,0.016942708,0.07244448,-0.039591815,-0.0077536763,-0.027466808,0.03396655,-0.1488576,-0.021630157,0.02788968,0.07096724,0.032613914,-0.07427874,0.0134770125,-0.047252283,-0.009074165,-0.03322491,0.052362844,0.014054436,0.0008494228,0.03333101,0.013357675,-0.02276125,0.06119261,-0.043615162,0.04548412,0.057121642,-0.029881842,0.019430425,0.02440258,-0.043043163,0.013314872,-0.006880755,0.009855714,0.014855036,0.095581144,0.0703787,0.06569683,0.040872212,0.029123258,-0.0064438847,-0.033757273,-0.018582549,-0.037086744,-0.008554048,-0.030712487,-0.082593195,-0.047261115,0.13181332,-0.0055707716,0.0027833255,-0.04277002,-0.06382435,-0.06870489,-0.004758136,-0.007459091,0.028642943,-0.09863625,0.04070026,-0.0053853015,-0.0774836,-0.039268065,-0.035789326,-0.08917088,0.019780692,-0.0060214484,0.0004992572,-0.08973925,-0.066385746,0.07653501,0.018172,-4.1607772e-33,0.06769408,-0.10156098,0.12508424,-0.055627108,-0.038477182,0.04137765,0.05393445,-0.030743383,0.0040989593,0.01532458,0.030004352,0.016736405,-0.0062915753,-0.03706632,0.020364122,0.02452229,0.11080061,0.07929948,0.03273389,-0.034640126,-0.058072176,0.065995984,-0.007808329,0.013425461,0.11038811,0.072714664,0.015675621,0.108012095,0.0023236445,0.010401411,-0.013228909,0.057385728,-0.008325037,-0.024570562,-0.01704673,0.071001224,-0.01835575,-0.0082681365,0.07745855,-0.035583086,0.00773193,-0.07251911,-0.007569963,0.04297766,0.0047789495,0.018470943,-0.06233598,-0.05079989,-0.035486396,-0.091525644,-0.020029819,0.004963243,0.058050044,-0.07270323,0.026506253,0.03998401,-0.047842115,0.026118323,-0.03241688,0.013185745,0.0061667264,-0.061664578,0.0031473972,0.061554555,-0.019167697,0.029151531,-0.02529615,0.029513573,0.05661659,-0.041363668,0.01320786,-0.036194913,0.06587742,0.10897907,-0.06645521,-0.089695744,-0.035217263,-0.079272576,0.06554788,-0.032796703,-0.035139225,-0.052989773,0.036395907,0.020422816,0.051482312,0.028175345,0.02226046,0.04749532,0.011684176,0.00061747554,-0.028499765,-0.0013862535,-0.0066731726,0.013745028,0.11986094,-3.0985777e-08,0.107682504,-0.08305414,0.028502755,-0.0005288485,-0.048208024,-0.046067085,-0.05144107,0.07425536,-0.00939829,-0.038865082,-0.052984368,0.017004227,-0.01651469,-0.0031832426,0.059923775,0.043013547,-0.059633534,0.009713484,-0.038742546,0.027557787,-0.02049857,0.016893744,-0.12002163,0.030608285,-0.007883871,-0.05517115,0.010627494,0.036281295,0.017329918,-0.025667911,0.044241164,-0.049408693,-0.020985285,-0.02145027,0.035600543,0.07242631,-0.07635718,-0.055685956,0.02267932,0.06386415,-0.0079657985,0.045897353,-0.058225583,0.006770537,0.004517349,0.030821217,-0.019237742,0.031629,0.03983351,0.020728352,0.076648176,0.021597203,0.0013264476,-0.036087148,-0.07895204,0.038649753,0.025542071,-0.036692586,0.029611489,-0.032534078,0.03376718,0.07073245,0.13044621,-0.033058044 +1.4.1.21,"The enzyme is strictly specific for L-aspartate as substrate. It produces the unstable compound 2-iminosuccinate, which, in the presence of water, hydrolyses spontaneously to form oxaloacetate. The enzyme from some archaea and thermophilic bacteria is likely to transfer 2-iminosuccinate directly to EC 2.5.1.72, quinolinate synthase, preventing its hydrolysis and enabling the de novo biosynthesis of NAD+.",384,1.0,-0.050710157,-0.063554026,-0.016158536,0.001828962,0.112656794,-0.010133151,-0.101276845,0.07236263,0.012326976,0.0010930856,-0.010943599,-0.10103469,-0.06060175,-0.020047147,-0.1420429,0.028530667,-0.020447552,-0.09625489,0.057510827,-0.01656837,0.077155754,-0.012593133,-0.049133897,-0.01004087,0.096460015,0.007942866,0.010353819,-0.026662596,-0.0114162015,-0.106044,-0.019766182,-0.042973742,0.06719295,-0.068483934,0.007662609,0.049149353,-0.025529567,-0.03831414,0.041867804,-0.035684776,0.054399382,-0.032900427,0.023494624,-0.0030172972,0.0047997655,0.003399099,0.04920892,0.04769725,0.0028889887,0.016201634,-0.055456568,-0.07251847,-0.051550295,0.039946433,-0.07742059,0.011945834,-0.01905795,0.035963565,-0.029714623,0.037186474,0.028569756,0.04809407,-0.012886341,0.011256027,0.019823207,-0.059515733,0.04021649,-0.043247014,-0.042301323,-0.026173439,-0.06834493,-0.028089006,0.06272193,0.028247243,0.08897072,0.014242122,-0.037050065,-0.033101033,0.04471834,0.025002437,0.046237823,-0.015199706,-0.03740858,0.014894453,-0.002800617,-0.038840674,0.03833238,-0.005098888,0.09535824,0.015123422,-0.0008245081,-0.0072829816,0.014765443,-0.012499978,-0.07863188,0.07667453,0.0018634113,0.082477495,0.070180595,-0.054636423,0.0069499924,0.095649056,-0.032391116,-0.06945337,-0.048359983,-0.05371453,-0.032901555,0.0869638,0.07807264,-0.027231082,0.028179789,-0.040371582,0.042878,-0.010406852,-0.022013895,0.08332649,0.057324212,-0.068846844,-0.08767631,-0.037740473,0.0059331665,-0.012471691,0.05859138,0.01877023,-0.029232446,0.040791374,-0.12222994,9.850428e-34,0.07333671,-0.004107144,0.015324738,0.039110843,-0.031485297,-0.012610509,-0.110206276,-0.02678614,-0.039999932,-0.075242855,-0.03965739,-0.10623863,0.016120696,0.031053921,-0.029394342,0.0029875624,0.024633886,-0.059839968,0.0075840624,0.062626846,0.014830678,0.05036918,-0.06152304,0.011113037,0.04498896,0.07813882,0.06801816,0.05458772,0.04786258,0.005504102,0.00037777613,-0.12310041,-0.11340615,0.015702281,0.09274525,-0.06440993,-0.04077273,-0.023616524,-0.021900866,0.011505551,-0.005217622,0.12463724,0.037080795,-0.039696857,0.073261686,-0.07117194,0.041778263,0.088859074,0.06478556,0.03087316,0.0060212407,-0.03524311,0.09608052,-0.03857563,0.001237641,0.036470383,-0.0446158,0.043536127,0.056444358,0.02795846,0.02524974,0.06325313,-0.007012172,0.050363418,-0.08085401,0.06914986,-0.050369706,-0.039233666,0.043652683,0.0934646,-0.08733232,-0.056696642,0.021350732,0.028118463,0.00935743,-0.082012415,-0.030737823,-0.0065208836,-0.006741862,-0.0042186845,0.007794336,-0.018962502,0.006721256,0.048711874,0.0031729196,-0.005518196,0.0014038078,0.016573759,0.025283137,0.07333101,0.06715924,-0.058567606,-0.012839389,0.010215244,0.031780615,-2.6228708e-33,0.07841486,-0.121443115,0.034155205,-0.10398227,-0.07546618,0.07101456,0.026641844,0.020229597,0.019285524,-0.040083,0.037403114,0.06781192,0.033115365,-0.026204651,0.014074903,-0.06700815,0.051250536,0.05585393,0.013907957,-0.0124090435,0.040056594,0.0637567,0.051852092,-0.013904201,0.07643116,-0.00056697073,-0.009629309,0.07237274,-0.0037321872,0.061361413,-0.052189708,0.00011696501,-0.017689027,-0.062428415,-0.04464454,0.011832812,-0.03475532,-0.07030143,0.0031914744,0.02220676,-0.026613766,0.03207143,0.019216869,0.033299074,0.0024570734,-0.0075466554,-0.07969663,0.022408577,0.04267569,-0.035185862,-0.019308606,-0.038238663,-0.023222549,0.029594112,0.025727497,-0.02590803,-0.06696263,0.06943767,0.001971494,-0.026311846,-0.05695909,-0.10119285,0.013721135,-0.10349694,0.05176147,0.053521357,-0.034041714,0.066545546,-0.008274683,0.028265093,0.06877881,0.015575424,-0.0029755565,0.020738395,0.022318933,-0.06507114,-0.08234771,-0.0127852475,0.014271448,-0.041552976,-0.045765582,-0.00405345,0.015517214,-0.05148093,-0.0039914693,-0.117085025,0.018949512,0.09467682,-0.04057133,0.04238619,0.010212342,-0.038295064,-0.07821947,0.062241253,0.015609655,-4.029149e-08,0.009376048,-0.041886415,0.063796535,-0.011269762,0.0036349902,0.06787048,-0.061589893,-0.029241303,0.06751641,0.025231516,-0.042154916,0.08255614,0.059620954,-0.010877139,0.018130157,0.011679745,8.197919e-06,0.067352764,-0.06635845,0.084388144,-0.014693284,-0.046267975,-0.118936844,0.028506432,0.0389054,-0.0424815,0.055534083,-0.024416948,-0.03562366,-0.056457616,-0.026329463,0.04156791,0.08075731,-0.049718753,-0.11673591,0.019121103,-0.060010538,-0.0033213934,-0.01510817,-0.023776304,0.052157525,0.032379813,-0.065639615,0.039837603,0.0075634657,0.049788907,0.010866144,-0.005711974,-0.05553589,0.027527483,0.05807909,-0.05979314,0.025524484,-0.031848893,-0.030011814,-0.02054736,0.014728227,-0.061341595,0.012520635,-0.036308404,0.04903263,0.023377126,0.19356023,-0.024896936 +1.4.3.1,A flavoprotein 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+1.4.3.2,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.4.3.3,A flavoprotein (FAD). Wide specificity for D-amino acids. Also acts on glycine.,384,1.0,-0.0577199,-0.102814116,-0.07903021,-0.04797399,0.055850577,0.027216779,-0.0090713445,0.060287777,0.052893743,0.0076661683,0.007906785,0.082444094,-0.05161957,0.014655371,-0.058881547,-0.0006169358,-0.027419588,0.0017430818,-0.11594104,-0.02737304,-0.029520825,0.05288501,0.0032524257,-0.039355446,-0.003507035,-0.022962417,0.04854808,-0.050361644,-0.004689486,0.0005063578,0.05334862,0.009219535,0.03882652,-0.0062122755,-0.052203014,0.041897133,0.025545992,-0.013564995,0.019596864,0.0043564443,0.036563266,0.011174258,0.058847442,-0.03110286,0.03126982,-0.00014766162,-0.029381225,0.06373327,0.00973545,0.0692728,0.017282313,-0.045179542,-0.11187534,0.026869353,0.015266862,0.046639714,-0.05817546,-0.026521591,-0.022735612,-0.009969542,-0.030598093,-0.008326203,0.0970129,0.0027017726,0.056301337,-0.060804125,-0.020287063,-0.012208947,0.040400937,-0.060031693,0.018230155,-0.035050664,-0.06361262,0.05505127,0.02831059,0.017283905,-0.07073869,-0.02703463,0.07193144,-0.06462967,0.0818909,0.0026719132,0.07488682,0.09419182,0.015726827,0.019407174,-0.02556053,0.032018434,-0.041572124,0.029353425,-0.0067453105,-0.023080166,0.02015741,-0.003174722,-0.0568365,0.02054307,0.038596958,-0.04449635,-0.1303656,-0.0076323394,-0.052058585,0.03375067,0.0041373027,0.031746432,-0.107638255,-0.05906541,-0.05480668,0.035734124,-0.06303924,-0.08485374,0.010597964,0.013056035,0.040659707,-0.058405567,-0.015502572,0.0063113063,0.016518822,-0.0134213185,0.02349376,-0.0570399,-0.038426474,0.10636922,0.08455653,0.09909339,0.016014758,0.025459908,-0.042812396,-7.111199e-34,0.09412221,-0.025915425,0.010513118,0.0357937,0.019724527,-0.015817475,-0.062276788,0.01744523,0.06648622,-0.013424018,-0.06519368,0.006103037,0.032172132,-0.029142339,0.04767388,0.0513955,-0.009948539,-0.04852608,0.04059475,-0.09725459,0.05113378,0.089488864,0.033621836,0.036509562,0.04709951,-0.03647868,-0.04653637,0.040356573,0.030077996,0.039071955,-0.094126634,-0.06473963,-0.07367375,-0.02740377,-0.018329488,0.036228195,-0.088601366,-0.11306379,-0.005617247,0.068703055,0.03420405,-0.06143352,-0.05295741,0.020468587,-0.0080854865,0.07024497,-0.048493735,0.062729925,-0.060619276,0.057826646,0.058976572,-0.078927554,0.08662996,0.048503723,-0.11008371,-0.0001423641,-0.045277014,-0.034070548,0.0072655934,0.07930391,-0.013895893,0.049706526,-0.004186543,0.06229514,-0.057967238,-0.04459828,-0.06692157,-0.040030133,0.020256579,0.090484634,0.039682936,-0.051491883,0.14328508,0.010453464,0.023183942,-0.08319729,-0.010880091,-0.033874422,-0.019758686,0.023430003,-0.003565485,0.004357007,-0.057563387,-0.0057441164,-0.033188853,0.020605877,0.015148164,-0.12246877,-0.009013433,-0.033191856,0.0060750223,-0.018862663,-0.011478409,-0.020670786,0.010848998,-5.5173003e-34,-0.0008219691,-0.13499986,-0.008309931,0.08192597,0.014696924,-0.016616395,0.0501606,-0.022147238,0.050243273,-0.07734298,0.02142234,-0.060530946,-0.07106669,-0.0035640502,0.010166916,0.042972587,-0.070603274,0.0078080096,0.017055951,0.025849737,-0.065679304,-0.06882143,0.031517874,0.05900889,0.057563853,0.0076494813,0.0072789025,-0.00019710498,0.010781163,0.06571741,-0.0029233224,0.06468091,-0.0709159,-0.024933476,-0.076400645,0.053049993,0.0046918485,-0.026581718,-0.045995645,-0.021834478,-0.021784771,0.055736978,0.047509525,0.073328964,0.06605706,0.0850741,-0.010149448,0.04138319,0.005158992,-0.047756623,0.025294404,-0.017216362,0.03556123,0.09965749,0.012551545,0.05967606,0.07163829,0.07739774,-0.011433973,0.06717256,0.008441999,-0.13334963,-0.004852181,0.019564945,0.053805493,0.02997089,0.05464881,0.078409985,0.018110188,0.030193254,0.09616437,-0.050622556,0.07205423,0.077479154,0.029683115,-0.00957667,-0.04559843,0.06891543,0.026273957,0.030063521,-0.056197222,0.0143350335,-0.039609134,0.07423461,-0.022409678,-0.12655257,0.015740277,0.13345836,0.012430665,0.03838164,-0.057955187,0.039505098,-0.01718793,-0.0009865912,0.053799845,-2.1848303e-08,0.058856614,-0.046744134,-0.0034231725,-0.016198196,0.07742377,0.05450886,-0.04848735,-0.008080872,-0.022595854,-0.04420872,-0.06294277,0.101477295,-0.046988573,-0.02670042,0.0052526137,0.05267673,-0.040867265,0.041773107,-0.02956407,0.0013373533,-0.06583185,0.08473979,-0.09672089,-0.038477816,-0.0869568,-0.018069243,0.0017998313,0.011603278,0.035891067,-0.017607637,0.036203615,-0.009166524,0.02116065,-0.097239435,-0.08455546,0.034785092,0.044657663,-0.06247468,0.016678013,0.02485004,-0.08586224,-0.0059220283,-0.0029175598,-0.010481941,-0.014273635,-0.016627895,-0.0020162407,0.04233002,-0.08320331,0.0063481187,-0.019678364,0.013842281,0.01731642,-0.020651646,-0.10003104,-0.033473596,-0.058121283,-0.085018694,-0.0043122754,-0.09269149,-0.041213688,0.047268543,0.062353745,0.047133043 +1.4.3.4,"A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [3]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22 (diamine oxidase), it is not inhibited by semicarbazide.",384,1.0,-0.05634547,-0.036802463,-0.08147712,-0.019910537,0.113417186,0.017273588,-0.035965312,0.014979965,0.039457142,-0.050449055,0.017472314,0.023622021,-0.07013459,0.0038636662,-0.042318683,0.06894523,-0.044057343,-0.03765332,-0.03939531,-0.00574934,0.03090901,-0.036363173,0.02307066,-0.036839657,-0.0045715505,0.0029091379,0.053479414,-0.035014875,-0.020067083,-0.062434003,0.043081187,-0.020201173,0.037034336,-0.014456052,-0.035533063,0.038953222,-0.004479589,-0.03513372,-0.029078094,0.032817483,0.025640978,-7.8962716e-05,-0.01752807,-0.050863102,0.053413585,-0.045988273,-0.009273683,0.027688542,-0.034541056,0.017021755,0.032550495,-0.026931891,-0.041639134,0.10345141,0.02954667,0.053882547,-0.06420593,-0.054159623,-0.047225956,0.07006915,0.017574972,0.043926675,-0.021787021,-0.039703887,0.020332167,-0.05933161,0.017800547,-0.09980222,0.058572624,-0.056961086,-0.0019846756,-0.11184103,-0.065700844,0.02627966,0.016027339,-0.027439479,-0.01340722,-0.043877628,0.035629205,-0.056976702,0.021234915,-0.04949892,0.08883076,0.1002991,0.0973962,-0.01100898,-0.05222153,-0.026397314,-0.004940097,0.10217198,0.042412993,0.010716624,0.029960504,0.07165597,-0.08968619,0.03400801,0.056691594,0.02464846,-0.076391324,-0.0011916616,0.023487289,0.05615523,-0.049785264,-0.054058563,-0.029347604,-0.024775889,0.047971163,0.06277168,-0.03970554,-0.044685546,0.0075775553,-0.014034064,0.03366642,-0.020549096,-0.0066281324,0.050565578,0.032103546,-0.06407343,0.023497764,0.015363621,-0.01401806,0.07533373,0.08953772,0.07088602,0.04040491,0.013989003,-0.09136969,4.689878e-33,0.03927322,-0.036663003,-0.056717712,-0.029826876,-0.043009967,0.009715725,-0.06963523,0.0257558,0.05883233,-0.064319246,-0.045465376,-0.033575974,0.028381383,-0.012969534,0.079828456,-0.018978845,-0.05238097,-0.06268948,0.11789693,-0.09201495,0.016885335,0.032281954,0.0010656326,-0.021852525,0.053398486,-0.060870443,-0.06819234,0.02981418,0.07621679,0.051972285,0.015865639,-0.12633772,-0.09088343,0.0015186801,-0.12385167,0.07433623,-0.11629336,-0.050347082,-0.098137304,0.08747624,-0.038335156,0.018001974,-0.033613615,-0.048924506,0.018509883,-0.055477694,-0.05084177,0.12650073,0.015567984,0.037063252,0.028143289,-0.0526065,0.08927063,0.039872035,-0.0641447,0.021050336,-0.046613693,-0.014980478,0.035225358,0.012032436,0.10868371,0.018079726,-0.026059788,0.061672717,0.042194366,0.023186134,0.0060611614,-0.08169124,-0.017600438,0.031421334,-0.06536916,-0.010439327,0.12876412,0.01802789,0.090426214,-0.094645046,-0.042197164,0.018709788,0.016486455,0.05321353,0.0141983405,0.0055018025,0.043612495,0.022847606,0.008618433,0.025884798,0.008993722,0.008437176,0.01986864,0.022918623,0.06362352,-0.06757147,-0.014030107,-0.007047647,0.026809305,-3.828744e-33,0.032921154,-0.092618875,0.03443553,-0.016669735,0.004739748,0.045963928,0.0045032157,0.0022380282,0.015543008,-0.06711708,0.080181986,-0.048954457,0.020324154,-0.032517154,0.08229702,-0.021990335,-0.10582207,0.0038879807,0.010354292,0.016208237,-0.024749111,0.027521588,0.0028972994,0.12216789,-0.0011526488,-0.032693274,-0.042976476,-0.042543035,0.027105464,0.048995573,-0.02744748,0.071959965,-0.06677527,-0.029675586,-0.065949686,0.053079993,-0.06888494,-0.014019086,-0.028024921,0.037215363,0.015134366,0.038089868,0.008285449,-0.031057019,0.03504901,0.07437972,-0.112103045,0.005740248,0.014860025,-0.06435507,0.011502613,0.04816288,0.0023870522,0.014729019,0.11431061,0.007343412,0.04229254,0.02966358,0.082959116,-0.009835736,-0.029916635,-0.04937782,0.020714484,-0.057571176,0.0909552,0.05190009,-0.026156588,0.16368192,0.043868523,0.023640612,0.084427044,0.00020061505,0.012440317,0.02296631,-0.030128215,-0.016499918,0.022703107,0.037123613,0.004399393,-0.026071394,0.01875736,-0.011305605,0.0032894274,0.0043488857,-0.06052608,-0.07268343,0.013141558,0.069907136,-0.02928045,0.017765388,0.037107754,-0.0504633,-0.038936775,0.030930232,0.034644302,-4.4692904e-08,0.039927714,-0.07626705,0.050488424,-0.007909696,0.020164857,0.071115784,0.023959327,0.004129591,0.005463047,-0.054645047,0.020031884,0.09248026,0.015956692,-0.005963427,-0.00052008306,-0.010659387,-0.030273627,0.05555373,0.0031834592,-0.044744223,-0.03940942,0.02983528,-0.12797135,0.021694321,0.032170255,0.0018499536,-0.019544471,0.022485735,0.04790992,-0.048869796,0.022244344,0.05605056,0.07233719,-0.010388226,-0.08227312,0.015811991,0.03694355,-0.044207856,-0.08927644,0.043722644,-0.0006698677,-0.07477548,-0.04958955,-0.025185144,0.07217987,-0.032245502,0.07949512,0.012685527,-0.0606857,-0.022389727,0.026550988,-0.04303912,0.067603774,-0.035202727,-0.08106899,0.0057671936,-0.040333167,-0.11756891,-0.038110703,-0.095092885,0.07156211,0.029145632,0.105732664,0.051357042 +1.4.3.5,"A flavoprotein (FMN). In Escherichia coli, the cofactor pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). N4'-Substituted pyridoxamine derivatives are also oxidized in reaction (1) to form pyridoxal 5-phosphate and the corresponding primary amine.",384,1.0,0.0073347394,-0.05408805,-0.09533015,-0.059879523,0.0740693,0.03892344,-0.10099848,0.024715304,0.02669424,0.0016644729,0.009364802,0.023121951,-0.091523305,0.06416989,-0.052439336,0.009203951,-0.057368916,0.02889993,0.033243477,-0.05131342,0.069602124,0.012065914,0.019124672,-0.0031670246,-0.017750867,0.040094536,0.05651816,-0.0020638392,-0.04808967,-0.049851354,-0.018775789,-0.01994247,0.020691546,-0.093666986,-0.0038754721,0.101216294,-0.04927543,-0.048348926,0.068059504,0.025955893,0.02400963,-0.04454247,-0.02476944,0.0009512766,-0.0039517274,-0.034906317,0.031967215,0.059424244,0.02399426,-0.023568375,-0.070752464,0.029740624,-0.038114663,-0.0353691,0.034445282,0.021843646,-0.010487302,-0.0039332453,-0.034236148,0.0028786138,0.004482205,-0.024911745,0.06459382,-0.03912422,-0.010347161,-0.0011743557,0.037710473,-0.07699365,-0.0046076966,-0.029285701,-0.0750828,-0.005534986,0.056907296,0.018025512,-0.05795625,0.11136356,-0.007682278,0.042833146,-0.041753363,0.0212526,0.054778997,-0.04268827,0.025209272,0.04578488,0.066789925,-0.005117008,-0.0690693,0.009763418,0.028934661,0.043296635,0.045167893,0.019438688,0.064749286,-0.0028873994,0.018974483,0.06547698,-0.03810282,0.072829515,0.013050634,-0.08829501,-0.016056221,0.022137033,-0.0750209,0.0298152,-0.038316507,-0.012767213,0.049469568,0.09157654,-0.006543852,-0.016237356,-0.055239722,0.006948318,0.012580541,-0.043968625,0.002898193,0.033899494,-0.010954642,-0.04554692,-0.044242598,0.081744544,0.040968094,-0.0020175625,0.04483045,0.09508767,0.0019503313,0.007710533,-0.12193644,6.035384e-33,0.08109714,0.1326249,0.030664733,0.01745124,0.019049238,-0.0024027764,-0.037732653,-0.030151187,-0.04447676,-0.06654451,-0.044113092,0.039745554,0.08620256,-0.05351583,-0.030794278,-0.05354101,-0.06907379,0.016321644,0.11405567,-0.014744316,0.06728948,0.042551275,-0.009403465,0.104358,-0.010950859,0.08307465,-0.052181024,0.004881049,-0.012213868,-0.004711636,-0.051447842,-0.1163565,-0.06911023,-0.053940475,0.052686505,-0.081958234,-0.07451408,-0.019797409,-0.07700724,0.059930418,-0.05182998,0.02781052,-0.028091926,0.007073431,0.049545497,-0.062162414,-0.09068092,0.10055495,0.006598695,0.08955005,-0.009096447,-0.004403053,0.11295282,-0.0070347157,-0.08928007,-0.0610746,-0.0216686,-0.040929917,0.021973945,0.025002731,0.0309382,0.051097993,-0.0333797,-0.030627161,0.010648561,-0.030287825,0.024662498,-0.08048439,0.044086408,0.08742768,0.029064292,-0.012243651,0.0556634,0.07389634,0.018740632,-0.050388724,-0.06932543,0.04076723,-0.02097356,0.010115622,0.018740075,0.031851936,-0.028321816,-0.0023793774,-0.0012944564,0.032122865,-0.008918361,-0.018007578,0.02728261,0.05207469,0.027845748,-0.12585588,-0.0006073173,-0.008984858,-0.0010533619,-4.518041e-33,0.09886814,-0.033389427,-0.0019288622,-0.023393853,-0.08239661,0.040956486,0.06207662,-0.032456838,0.061601732,-0.038276043,0.039655995,-0.027456764,0.017274188,0.005744718,5.7415393e-05,0.028899213,-0.0392198,0.038780943,0.05881227,-0.0010935196,0.045206282,0.01315682,-0.03891524,0.07825376,0.11025291,0.07175185,0.045296278,0.01058477,-0.016344072,0.01830567,-0.08555393,0.028507167,-0.017901935,-0.014861819,-0.033208866,0.05316442,-0.10485398,0.051866457,0.014205084,0.025582818,0.026708877,0.09698474,0.04051257,0.00034071042,-0.015777534,0.040944435,-0.04189858,0.049330357,0.023106538,-0.016861364,-0.01199547,0.041127153,-0.09447934,-0.0012820589,0.021696966,-0.008203212,0.051514618,0.07347718,0.0063066175,-0.009956813,-0.033319972,-0.08500701,0.071206406,0.026363473,0.017572867,0.05815743,0.030008199,0.088791765,0.01903868,0.03683064,-0.033373356,-0.015699307,0.080632724,0.059290666,-0.01010148,-0.0027435645,-0.058608867,0.067475416,-0.013503876,0.025212552,0.023910815,-0.0577263,0.009539009,-0.07706675,-0.0081837885,-0.05904696,0.08615813,0.10010116,0.040640675,0.02713335,0.03142401,-0.04258574,-0.013244462,-0.0069145802,0.045169067,-5.1826692e-08,0.0644163,-0.051469292,0.0015818283,-0.01997183,0.07658197,0.017311377,-0.0011787092,-0.03368365,0.068755,-0.059268277,0.026900146,0.043316003,0.029163087,0.010248931,0.030644583,0.009716406,-0.07560765,-0.005158406,0.019041328,0.013707541,-0.09116709,0.0055057793,-0.17849828,0.005292372,0.07615187,-0.037122834,-0.038292687,-0.10037851,0.07371466,-0.02815567,0.031535428,0.012219169,0.059457727,-0.08566663,-0.09093556,-0.017132102,-0.045964174,-0.0028752782,-0.06675157,0.032171182,-0.08050293,-0.08115869,-0.03801761,-0.010048922,0.03663069,0.046797905,-0.023122827,0.021600889,-0.050986167,-0.059909813,0.020308249,-0.038620014,-0.022484545,-0.08490301,-0.11399161,0.027910467,0.03799936,-0.06349445,-0.02118976,-0.13071536,-0.014508417,0.008929601,0.13694705,-0.05024971 +1.4.3.6,"A group of enzymes including those oxidizing primary monoamines, diamines and histamine. They are copper quinoproteins. One form of EC 1.3.1.15 orotate reductase (NADPH) from rat kidney also catalyses this reaction.",384,1.0,-0.046732984,-0.017340872,-0.023201142,-0.01903089,0.044679526,0.0060910312,0.023940077,0.015538119,0.032416385,0.031750847,-0.026649278,-0.07456416,-0.027314728,0.025668964,-0.067046754,-0.012477483,-0.0813819,-0.06706925,0.003365665,-0.019133355,-0.008081204,0.01705619,-0.024363412,-0.025986161,0.01615596,0.10453725,0.048455846,-0.01159054,-0.00976874,-0.074463025,-0.01808632,-0.04288102,0.026661767,0.014439382,0.04334385,0.064938925,-0.07835247,-0.036826774,-0.022072325,0.018809242,0.02907465,0.039431587,0.0023452272,-0.029533489,0.002614356,-0.038694043,0.03669337,0.043275904,0.013384848,0.022572435,0.024289677,-0.012684799,0.015987258,0.13422911,0.08398813,-0.002444573,-0.09780244,-0.07136788,-0.027168509,-0.041480146,0.011486266,-0.0023745862,-0.011913272,-0.040593553,0.07016795,0.027275985,-0.015367659,-0.019370614,0.0046259467,-0.097765625,-0.059689555,-0.07694143,-0.006138737,0.015055212,-0.010691121,-0.03162325,0.0061307102,-0.052550025,0.04716452,0.008088617,-0.045601074,0.037546065,-0.03272577,0.04601265,0.11368195,0.06639689,-0.01297051,0.03911148,0.0025845387,-0.032577664,-0.02017513,-0.050641328,0.008597162,-0.047545288,-0.060463123,0.024409004,0.010187434,0.012773373,0.039568584,0.011493805,0.039770663,0.09921736,-0.022066837,-0.09942134,-0.06434378,0.036118947,-0.0062609483,0.15357974,0.0086616315,0.007148229,-0.026904535,-0.05476693,0.009560082,-0.012986478,-0.006762426,0.09403073,0.01202454,-0.044302896,-0.07660353,-0.015470837,0.021551432,0.018031072,-0.011447698,0.05212919,0.007173773,-0.026562426,-0.10425869,2.9000246e-33,0.09304893,0.034558687,-0.032793537,-0.033443145,0.037367243,0.08943449,-0.027058614,0.083423056,0.046460867,-0.10291078,-0.06648362,0.011854931,0.07206217,-0.009717323,-0.023747483,-0.031629477,-0.039971128,-0.012950861,0.094824255,-0.11414188,-0.010193434,0.080122896,-0.03283826,0.03401367,-0.021325292,-0.012456036,-0.056460828,0.021619562,0.03128949,-0.0049911793,0.015232061,-0.0060524424,-0.02086344,0.039269682,-0.04589152,-0.014181937,-0.018243209,0.0066861,-0.019001352,0.11183252,-0.04611931,-0.00024079991,-0.04295209,-0.04075414,0.044961922,-0.11553334,-0.102152735,0.08988895,0.02084486,0.027715608,0.038898837,-0.041247565,0.113900974,-0.07891633,-0.09569397,-0.0011746652,-0.07576924,-0.074529134,0.027166663,0.053741865,0.013395419,0.045720242,-0.09311779,0.065683566,-0.036756832,-0.013881093,-0.02281636,-0.057607394,0.026341762,0.106822796,-0.11928041,0.011688506,0.029325774,-0.009464315,0.0331787,-0.03714384,-0.07717887,0.015500367,-0.004086754,0.06535765,-0.0475571,-0.018733358,0.0052049197,0.062488202,0.0048447703,-0.024476804,0.0059411908,-0.07306311,0.015835155,0.026879791,-0.023122197,-0.035975885,-0.096103825,-0.03154374,-0.003179172,-4.1425012e-33,0.10736042,-0.07683308,-0.045881055,-0.049700577,0.01659052,0.03005666,0.028488344,-0.021148631,0.035655227,-0.03580521,0.038895063,-0.033505782,0.066874,-0.034694422,0.05419934,-0.038679894,-0.008103522,0.10170688,0.017883701,0.027414342,-0.02727587,0.02114791,-0.048605576,-0.0019657058,0.044552863,0.011447831,-0.06458028,0.0022851562,0.09746513,0.06691687,-0.06366536,0.031522,-0.02359507,-0.024498045,0.007262331,0.09482139,-0.05201823,0.00069171144,-0.03632884,0.00956804,0.04122387,0.012362848,0.0465916,0.07384786,0.025788551,0.038773987,-0.095600285,0.04000123,-0.10128396,-0.025293102,0.03946251,0.06090883,-0.024081647,0.012053457,0.06786518,0.00369475,-0.0021780606,-0.03424439,0.065483265,0.0005506728,-0.05292492,-0.03224402,-0.009701097,-0.002748559,0.029990476,-0.04247041,-0.040272996,0.054744747,0.016613841,0.038268413,0.10380527,-0.011021586,0.06243079,-0.0013922595,-0.026784858,-0.062258337,-0.053853568,0.03036889,0.043595534,-0.049978696,0.022027109,-0.0025282032,0.073299885,-0.01662027,-0.07939209,-0.009293389,0.033837214,0.15244965,0.016118085,0.038965188,-0.032043185,-0.053838428,-0.07033237,0.13269287,0.060599927,-3.6700325e-08,0.017192058,-0.032951917,0.04440432,0.030668318,0.0064864433,0.08457065,0.105177894,0.049969204,0.02659199,-0.021407537,0.0550975,0.09346649,0.042188283,-0.063424125,0.0070687616,0.045750424,-0.0096039,0.010251466,-0.019966893,-0.029983079,-0.049477726,-0.029747589,-0.03656916,0.02469031,-0.008832335,-0.0519582,-0.03530794,0.02067448,-0.10042583,-0.028629525,-0.012838858,0.0094355475,0.058930483,-0.10944978,-0.039154217,0.038176004,0.042259313,0.0018960435,0.01977736,-0.054400925,-0.052872412,-0.048979763,-0.076195285,-0.024008418,0.027875908,-0.049023725,-0.009251249,0.0086599225,0.017115032,-0.052491363,-0.007992976,0.0072998735,0.043697443,-0.0868277,-0.059008148,0.02445781,-0.018161913,-0.10904265,-0.05227055,-0.050546195,0.08870649,0.07762903,0.16289587,0.027344102 +1.4.3.8,A cobamide-protein.,384,0.99999994,-0.0013159194,-0.04288797,-0.13098638,-0.082895935,-0.07467786,0.01169255,0.07214399,0.08746791,0.051308453,0.0024101743,0.08074216,-0.07431328,-0.033590034,0.010518958,-0.05652825,-0.01889104,0.050298788,-0.017059674,0.0048900717,-0.017975787,-0.01406379,0.0652734,-0.013225938,0.030840585,-0.0662088,0.04714496,0.068708204,-0.008589048,0.0012259397,-0.09884352,0.09090932,0.0002214727,-0.015695438,-0.036815945,0.034245174,0.022504423,-0.032075815,-0.07082108,0.10581712,0.02950673,0.05880459,0.02579869,0.027146943,0.002845932,-0.011400361,0.011055914,0.012850197,0.06533813,0.07209888,0.0368174,-0.04111053,-0.11165359,-0.031516332,0.036383517,0.00927386,0.032397203,-0.13355651,-0.010338404,0.05590216,-0.029217422,-0.032953385,0.0021866916,0.10568089,0.06981809,0.0669892,-0.04610568,-0.00856031,-0.07456208,-0.015185001,0.06130558,0.026809556,-0.058798615,0.06869807,0.020422937,-0.054750666,0.018309094,-0.07879071,-0.044608716,0.06939554,-0.0088914335,0.009184168,0.022779355,0.059272446,0.102090985,0.040716037,0.011258761,0.06422662,0.0035218624,0.026379982,-0.05364122,0.013199139,0.0041201166,0.06792136,0.0007495128,-0.100964755,-0.028306566,0.02438834,0.029059451,-0.0361173,-0.0341915,0.015547697,0.0698472,0.04110065,-0.012264462,-0.09591605,-0.026407328,0.04546753,0.11209218,0.036049735,0.019250253,-0.06695829,0.015489805,0.037194703,-0.06051125,0.022380387,0.027434705,0.09897282,0.011357989,-0.006937693,-0.030251991,0.045716394,-0.03518163,0.02913203,-0.013579352,0.0095628705,0.034799665,-0.066568084,-5.2877883e-33,0.07557729,-0.0055430024,0.06151955,0.071915306,-0.026310697,-0.044224285,-0.06984877,-0.054718673,-0.05071093,-0.07733962,-0.04689981,-0.03441895,0.0164,0.04086444,-0.021499442,0.022719387,-0.040704634,-0.002943528,0.0864011,-0.026042607,-0.024491023,0.14232081,0.04599013,0.056361675,0.044453364,0.008925835,-0.0034288203,-0.0110515505,-0.010007782,-0.0054182787,-0.011777262,0.03209488,-0.08729862,0.003047902,0.044886027,0.013109237,-0.05157851,-0.060182482,0.0003198944,0.044893406,0.014790622,-0.055031475,0.011549404,-0.04999581,0.07949173,-0.047863282,-0.04189028,0.029122086,-0.051332887,-0.0035352237,0.06843092,-0.030393222,0.057639495,0.018631635,-0.09880273,0.017978907,-0.06989538,0.045464717,0.014788982,0.06823847,-0.01242433,0.05296558,-0.08656482,0.063118316,-0.05190742,-0.008469129,-0.06542347,-0.04598261,0.01100245,0.012783989,-0.018563498,-0.11129808,0.104105815,0.0071675368,0.011996981,0.020076059,-0.062442027,-0.056790277,-0.05796247,0.0036650216,0.017868852,-0.09776565,-0.01503876,-0.003884741,-0.007345689,-0.04140875,-0.018757418,-0.045082927,-0.02030058,-0.0024159912,0.058243275,-0.06109977,-0.034915995,0.015733156,-0.061935786,2.6213827e-33,0.041223608,-0.08634721,0.060214035,0.024892978,-0.03837933,0.029023346,0.106008776,-0.052126408,-0.009161111,-0.045124102,0.0850945,-0.003239357,0.002090677,-0.07342943,-0.0054642786,0.08547224,-0.029261045,0.025733165,-0.0018980964,-0.08208994,0.0039973846,-0.012612421,0.025325732,-0.032260824,0.010731284,0.13630572,0.047816787,0.033253063,0.029441863,0.01663744,-0.023504838,-0.0032332314,-0.042373728,-0.10425345,-0.07396662,0.013364612,0.0068558166,-0.043478377,-0.006786898,-0.12394588,-0.052542932,-0.0016865946,0.028695041,0.05203355,0.107385546,0.02176769,0.0022376038,-0.039127138,-0.012762523,0.046475276,-0.025820276,-0.0043839035,0.008173069,-0.026972452,-0.012753622,0.014016642,-0.020903127,-0.012765151,0.058628898,0.023442702,-0.00029538537,0.015221756,0.05430363,0.08086251,0.022777626,0.0053022695,0.010082974,-0.0025716575,0.063410595,0.033065014,0.045872606,0.05009447,0.02556787,0.036945276,0.003292988,0.034796365,-0.10051313,-0.0044645257,0.003397109,0.034865566,-0.13902494,-0.058190607,0.039686967,0.018720787,0.034455985,-0.017639901,0.016699275,-0.034631506,0.011449206,0.012512927,-0.030951938,-0.025295278,-0.029853571,0.06364804,0.051268846,-1.5468807e-08,0.085876375,-0.062715046,0.0006709653,-0.14538004,0.051044635,0.091092624,-0.051771797,-0.04782932,0.062386397,0.0040224376,0.012591626,0.050057482,0.031065894,0.092042185,-0.017537663,0.0536154,-0.046955947,-0.07968016,-0.025653938,-0.10359582,-0.06501148,-0.015470367,0.0060331402,0.07028059,-0.012292325,-0.05081236,0.010877831,0.09501129,-0.06828741,-0.007719466,-0.04879171,0.04751859,0.062602945,-0.05054771,0.007460265,0.025081625,0.0042349314,-0.011587084,-0.0043422906,0.014837813,-0.019744748,0.03177617,-0.06356973,-0.007711078,0.10374496,0.009107885,0.010739876,0.07185745,-0.06903707,-0.03841733,-0.0023520726,0.03315869,-0.066058554,-0.008840388,-0.076335445,-0.02141242,-0.07358651,-0.04598787,0.013664133,-0.06331803,-0.060075868,-0.04982414,0.11628689,-0.014223325 +1.4.3.10,A flavoprotein (FAD). 4-Aminobutanal condenses non-enzymically to 1-pyrroline.,384,0.99999994,0.0028134438,-0.11458338,-0.08757126,-0.03844284,0.092790596,0.059218217,-0.012552688,0.072597794,0.05212057,-0.033027217,0.017823,0.053366974,-0.04560361,-0.010481409,-0.07485572,0.05446873,-0.064898305,-0.03763955,-0.058421332,-0.056626145,-0.035915393,-0.03884549,0.014835855,0.009240245,0.014840133,-0.007491619,0.018712591,-0.053457994,-0.030870713,-0.021127343,0.07278743,0.055769663,-0.01340635,-0.010571355,-0.01282043,0.05347245,-0.007925267,0.01815415,-0.024694897,0.0056529287,0.10758516,-0.0030423168,-0.015506156,0.0075585963,0.011813618,0.012683309,0.005316729,0.06349529,0.044625733,0.029880555,-0.031103771,-0.02953409,-0.111831054,0.026763279,0.0023511106,0.06556666,0.00860777,-0.008096629,-0.057589445,0.044426274,-0.023029223,-0.0036273773,0.029561928,-0.05260259,0.06971793,-0.015530079,-0.027848557,-0.007854536,0.09664793,-0.009835884,-0.02365554,-0.004452667,-0.03233192,0.09999835,0.0016906761,0.019103993,-0.07969298,0.0055549657,0.05169401,-0.0073872516,0.057842612,-0.016002031,0.072096825,0.06626676,0.04154503,-0.018560594,-0.007267815,-0.023141291,0.0033086662,0.035008486,0.015876781,0.043434843,0.0304754,0.016647344,-0.06174541,0.059278395,0.025849886,-0.047052998,-0.07065311,-0.033024076,-0.022808101,-0.015983487,-0.025638716,-0.031812496,-0.09213861,-0.04064195,-0.017525844,0.028300984,-0.040355407,-0.042808942,0.00032926776,-0.031626634,0.0647318,-0.066305585,-0.014799952,0.021774007,0.023589566,0.00010514355,-0.040705334,-0.00017303255,-0.030705549,0.14245939,0.14992313,0.10541322,0.012403099,-0.028062142,-0.041760724,1.0484898e-33,0.07233886,-0.018044626,0.032275863,0.06724118,0.006059948,-0.006229719,-0.03982066,0.010110892,0.05106034,-0.01935066,-0.01738184,-0.057676118,0.0035158098,-0.06169584,0.036744587,-0.016170882,-0.036937192,-0.02628141,0.06613257,-0.09263248,-0.014057837,0.09702471,-0.0035815963,0.07966811,0.012544625,-0.026935088,-0.0539532,0.016091712,0.029916266,0.019165436,-0.04540235,-0.030940805,-0.14489968,-0.031712603,-0.022050308,-0.02231043,-0.09901998,-0.077483945,-0.054914005,0.089390315,-0.030581638,-0.049320713,0.009544415,-0.03043304,0.029474791,-0.01593377,-0.10225052,0.10333232,-0.044534612,0.042713255,0.044950854,-0.039211996,0.110172555,0.07990237,-0.09636169,-0.0012607976,-0.0041087074,-0.016152117,0.03291999,0.025300186,0.019047959,0.06935915,-0.059863545,0.04605244,-0.063239105,-0.032479152,-0.013240514,-0.03652678,0.023603141,0.08890089,0.04401659,-0.024739644,0.073682,0.026430134,0.07883424,-0.07634454,-0.079154536,-0.013664896,-0.036952175,0.042444352,-0.015064895,-0.013173996,-0.015189015,0.016299913,-0.046300475,0.0006104168,0.03843984,-0.017215714,0.010640838,0.011700931,0.008173438,-0.047125462,-0.008302789,0.023155063,0.030609151,-8.933447e-34,0.03006217,-0.09986391,-0.013328077,0.08459678,-0.007861522,-0.0104059065,0.06577477,-0.04829612,0.029365828,-0.028388867,0.05158214,-0.05242794,-0.06525632,0.01678476,0.06536155,0.053006615,-0.08754486,0.015269558,0.038746722,0.042091954,-0.06150646,-0.047749583,0.027800735,0.10137625,0.052099556,-0.0112600885,0.039534293,0.026251148,0.046802502,0.06935847,-0.025800627,0.022126889,-0.051526137,-0.030561844,-0.11075555,0.00048523652,0.01839813,-0.002373972,-0.005962096,0.01693802,-0.023961471,0.057699684,-0.0075995834,-0.0061217705,0.042781886,0.027987078,-0.021323593,0.022458196,0.0153141,-0.045827344,0.03888899,0.020624096,-0.0109972665,0.0468284,0.013252798,-0.010860976,0.041256838,0.049188983,0.039538987,0.014013334,-0.02676031,-0.141015,-0.0048643267,-0.0146447485,0.048381962,0.07225593,0.07398779,0.12884218,0.025690066,0.005399443,0.1248215,-0.030743368,0.110828966,0.085298665,0.057938166,0.010874149,0.0477815,0.06356323,-0.00047110958,-0.062090963,-0.03213079,-0.0289403,-0.011275322,-0.058271088,-0.07731966,-0.14509362,0.07555733,0.07061776,0.014658913,0.069392025,-0.018685965,0.023305245,0.037982132,-0.005198113,0.087163284,-2.5126086e-08,0.039849382,-0.016642723,0.030433454,0.0329648,0.07478511,-0.0018848269,-0.018479113,-0.0036910924,0.0051073623,-0.031508666,-0.07593875,0.057831373,-0.018785335,0.030128608,0.03200073,0.015839206,-0.015742758,0.028017325,-0.0138259195,-0.04373168,-0.101862006,0.06919798,-0.15969023,-0.04936591,-0.067954615,-0.028839124,-0.011755013,-0.010490986,0.034304176,0.0004916831,0.040646084,0.021905271,0.057259396,-0.09314611,-0.107109904,0.019864587,0.019078711,-0.057161666,-0.02536515,0.022299185,-0.120273866,-0.0018839038,0.024519274,-0.060516328,0.0026057814,-0.045283716,0.027643366,0.008314104,-0.022594094,0.020582113,0.04250382,0.02672415,0.0048656687,-0.04425067,-0.071907066,0.0037464444,0.0003109939,-0.075308636,-0.0245735,-0.120020285,-0.0933174,-0.013139246,0.092889875,-0.008668572 +1.4.3.11,"A flavoprotein (FAD).The enzyme from Azotobacter previously listed under this number, which did not produce H2O2, was a crude cell-free extract that probably contained catalase.",384,0.99999994,-0.03859164,-0.042943433,-0.13530461,0.057166286,0.084603,0.039863463,-0.015236468,0.093002595,0.034900554,-0.016151134,0.029773373,0.042144373,-0.03563758,-0.022327542,-0.048671436,0.027159518,-0.04788626,-0.017410139,-0.059805743,-0.009139513,0.027560074,0.039359227,0.033298075,-0.042246375,0.014924685,0.02515929,0.0021356598,-0.030864343,0.015026045,0.02264624,0.072238885,0.033341076,0.053314112,-0.029045485,0.026331099,0.014510893,0.06544568,-0.09193138,0.05766339,-0.0045479056,0.07171011,0.013062764,0.027751422,0.0250181,0.03448664,0.048409946,0.056659013,0.030941423,-0.0369963,0.0064786314,-0.07885085,-0.025494447,-0.10409301,-0.008910534,-0.029314788,0.02872944,0.021191658,-0.04890219,-0.009609057,0.023545705,-0.027664924,-0.027903456,0.073544756,0.02114827,0.052639063,-0.10794195,-0.08723809,-0.03044743,0.052899156,-0.05115025,0.009584246,-0.017947378,-0.021722782,0.022283295,-0.013711772,0.0179321,-0.01603273,-0.021225639,0.05605905,-0.006586538,0.052171104,-0.065416224,0.13776258,0.11755235,-0.004917533,-0.018986868,0.03894062,0.009811712,0.010127834,0.0755213,-0.00048465352,0.015795857,0.062473875,-0.019082634,-0.06450757,0.00712665,0.034230556,-0.04513337,-0.05399215,-0.033658937,-0.0290258,-0.004786756,0.002149765,-0.026139209,-0.09530612,-0.050163202,0.015890408,0.060548604,-0.0040686387,0.015447754,0.034659967,-0.011430663,0.007525138,-0.08633711,0.0200992,0.01719972,0.07031695,-0.07356676,-0.039446887,-0.0016915784,-0.054510023,0.025924113,0.08558726,0.05206636,0.029405443,0.007570676,-0.10312399,1.0119799e-33,0.037752777,0.0143316705,-0.04142547,-0.04945259,0.02576595,0.010856917,-0.07121232,-0.03743676,0.045872483,-0.02894755,-0.11635628,-0.05138639,-0.0012241884,-0.055683125,0.011727601,0.03539954,-0.06366195,-0.043707885,0.09029335,-0.017370684,0.030478204,0.02385492,0.01852005,0.055555172,0.014036395,0.046202485,-0.050372303,-0.049232304,0.026658535,0.009560726,0.02148559,-0.07531441,-0.09653197,-0.035159156,-0.04195307,0.036421612,-0.1056313,-0.050249305,-0.09017625,0.059248246,0.03825014,0.014854049,0.035744015,0.0012499287,0.058373664,-0.05412356,-0.09748692,0.075912006,0.02377622,0.06764706,-0.0033992785,-0.032409005,0.0826071,0.05998261,-0.10643799,-0.02266075,-0.036358092,0.06932651,0.07968306,0.08012362,-0.025418576,0.07577588,0.020092279,0.108205155,-0.08381042,-0.022828436,0.030159017,-0.024453811,0.04392236,0.14678483,0.03707152,-0.03564289,0.10743701,-0.0016690413,0.06189859,-0.09735217,-0.006926964,-0.077431336,0.013976322,0.022410646,0.032299235,-0.02570326,0.052890122,-0.0113577945,-0.011042538,0.0091605345,-0.09119642,-0.0015556306,-0.03256021,0.053312045,0.008886948,-0.0056663305,-0.038039032,-0.004825016,0.050086975,-1.7794403e-34,0.03098478,-0.09203432,0.03300672,-0.054246545,0.013572493,0.036709037,0.00703998,-0.012980063,0.058349032,-0.022613816,0.07460005,-0.029518206,0.019069253,0.016916057,0.03241226,-0.00116872,-0.041203946,0.011730142,0.08552169,0.029336978,-0.060983296,0.01078746,0.010024691,0.07814864,0.049921837,0.029750325,0.017253729,-0.0127341,0.03887464,0.039100457,0.008506164,0.011858641,-0.08508671,-0.059421286,-0.10493463,-0.0026007101,-0.02362235,0.018793453,-0.038684927,0.030352974,-0.011893499,0.020902982,0.018627279,0.07687585,-0.008793808,0.020280804,-0.040605463,0.024542268,0.03202659,-0.036722872,-0.00073987676,4.842388e-05,-0.03305733,0.051852614,0.042993344,0.028033804,0.02650378,0.07734424,-0.046060503,0.05371227,0.002406312,-0.076844834,-0.012078416,-0.038609277,0.0986698,0.10577721,0.08738328,0.08987319,-0.036297705,0.008478995,0.120472066,0.035432663,-0.010946921,0.054932006,0.018000329,0.056589194,-0.06394083,0.069491215,0.014559356,-0.015866173,0.042362027,-0.014844566,-0.014192795,0.01498985,-0.006272086,-0.105920285,-0.04114033,0.06630453,-0.021546746,0.03935867,-0.001250362,0.0002548095,0.021453986,-0.05645741,0.0036359418,-2.9289199e-08,-0.027179077,-0.08853657,0.021429824,-0.0032342817,0.08497456,0.03798224,-0.10687027,-0.025260989,0.024111949,-0.04160836,-0.016427074,0.05850394,-0.025142089,0.017633192,0.062024403,-0.021814244,0.033082027,0.0023938562,-0.019987276,0.008902521,-0.10375146,0.046080697,-0.10755161,-0.018109659,-0.05379949,-0.040773116,-0.0359785,-0.048831154,0.014838041,-0.05962671,0.055151284,0.00019251855,0.049515277,-0.08606513,-0.12977012,0.020411516,0.082501955,-0.14401472,-0.026800608,-0.046242334,-0.047832586,0.020375418,0.028627526,-0.059099298,-0.04520917,0.0300405,0.032698795,-0.06780847,-0.036738373,-0.05694275,0.008794605,-0.011557197,0.02132608,-0.026686465,-0.06936702,-0.0047545484,0.037106417,-0.09014093,0.013888039,-0.053674348,0.034634482,-0.006889769,0.13754225,0.018931469 +1.4.3.12,"A flavoprotein (FAD). Some other cyclic amines can act instead of cyclohexylamine, but not simple aliphatic and aromatic amides.",384,0.99999994,-0.07327997,-0.10446157,-0.0759234,-0.019615596,0.08679807,0.0006052982,0.023417542,0.053105835,0.055200137,-6.62495e-05,0.016683204,0.04082681,-0.03831229,0.024377085,-0.03621933,0.02519444,-0.051927738,-0.049037557,-0.018682446,0.028981855,-0.052230332,0.033848535,0.04800776,0.003088774,-0.026377093,0.028952759,-0.010223049,-0.037536323,0.0021488282,-0.0009997169,0.08492347,0.10602729,0.052853648,-0.005212627,-0.03984411,0.046162,0.013976969,0.025842369,-0.020612942,0.01298282,0.011078635,-0.010342255,0.062741175,-0.06907299,0.062744066,-0.030955408,-0.0077817966,0.03354285,-0.011997395,0.02678407,0.02753762,-0.05647368,-0.076135516,0.05223901,0.0056982753,0.03924031,-0.082099654,-0.028604664,-0.048451453,0.025073763,-0.03777078,0.011771598,0.01300598,-0.000929959,0.0403947,-0.02808696,-0.06168686,-0.060031977,0.07349217,-0.018714454,0.012581857,-0.07087704,-0.04216575,0.03634171,0.021802513,-0.001559965,-0.04724041,-0.060155243,0.019706102,-0.027789919,0.027932001,-0.029839296,0.092622444,0.06219938,0.08414955,0.00593692,0.003918963,0.0049458314,-0.03276325,0.031433083,-0.04275538,0.03102325,0.020410234,-0.009085912,-0.043933526,0.020533802,0.08428043,-0.037321422,-0.067044504,0.04075253,0.003776878,0.025897598,-0.033685125,-0.042095017,-0.09401028,-0.06750722,-0.0038193255,0.02459087,-0.07551857,-0.051388733,-0.030112999,-0.022369616,0.041019257,-0.10820182,-0.005901086,-0.016711831,-0.01230951,-0.0591328,0.028576963,-0.044916928,-0.061133865,0.084723,0.033387616,0.11802955,0.05891363,0.030466342,-0.056270573,1.7360193e-33,0.0649728,0.01306019,-0.010301675,-0.007749357,-0.009277593,0.039376404,-0.036031913,0.005435727,0.06745774,-0.095047764,-0.015377597,0.042610154,0.045060787,-0.06144504,0.0900377,-0.028690957,-0.0570013,-0.013871672,0.10665625,-0.1630405,0.01810628,0.09223222,-0.0051555587,0.045630258,0.003791207,-0.042602114,-0.04780961,0.03675956,0.036706235,0.02246578,-0.035050713,0.0022534449,-0.064157195,0.015883766,-0.049077023,0.08168794,-0.15051918,-0.09384003,-0.12169935,0.06771416,-0.025468132,-0.02171559,-0.018145343,-0.002503031,-0.011828807,-0.016355565,-0.07735835,0.089007474,-0.055144057,0.034771275,0.037143175,-0.023317475,0.08543738,0.07806056,-0.11706818,0.042298026,-0.029112464,-0.044533104,-0.01524977,0.0037518186,0.024795236,0.019151032,-0.053877845,0.049736265,-0.101941146,-0.01774829,-0.028935248,-0.0359292,0.03552096,0.13822258,0.03476474,-0.009215654,0.095153734,0.050227012,0.109667726,-0.04549856,-0.012294336,-0.01435934,0.007975035,0.050388347,0.023045005,-0.069210015,-0.011426647,0.018436292,0.000104202554,0.0022242018,0.0080988165,-0.013407493,-0.0020005032,0.016954912,-0.017030802,-0.11528368,0.050711047,0.035883658,0.028754674,-2.4930683e-33,0.04143209,-0.08580399,0.008846114,0.06243108,0.04411689,-0.0149391135,0.050649825,-0.07411579,1.7383085e-05,-0.08318889,0.03286317,-0.06419421,0.0013357552,0.03311389,0.026414236,-0.0046280096,-0.051729333,-0.02040829,0.08495413,0.07179724,-0.06296045,-0.05053883,0.018181298,0.07216108,0.05581847,-0.0025425097,0.00047730614,-0.03928905,0.024942674,0.051728964,-0.09221831,0.02854019,-0.058932755,-0.07100475,-0.060362812,0.059347454,-0.030302076,-0.036393408,-0.06877327,0.008632746,-0.03592807,0.021715429,0.043013666,0.077556744,0.06472754,0.061538953,-0.047764994,0.052319672,-0.019411633,-0.052858405,0.025640761,0.033027466,0.0012120866,0.021315498,0.058276996,0.045759596,0.040895365,0.04135653,0.023512792,-0.0014345422,0.01631005,-0.07922418,-0.029255059,-0.0086615775,0.057139196,0.022074105,0.00041336872,0.08620586,-0.03522583,0.011249597,0.14875947,-0.041795276,0.078493334,0.071799956,0.02410853,-0.056191858,0.024621196,0.04033139,0.003362003,-0.020989392,0.060252514,-0.025390526,0.02313219,0.05712018,-0.106112786,-0.041384097,0.018262196,0.02052637,-0.038700297,0.039862126,-0.00063877285,0.09328444,0.052748773,0.027130205,0.06262024,-2.8135318e-08,0.01586183,-0.055199824,-0.01551235,-0.041735765,0.080223665,-0.0018755612,-0.028518744,-0.05593616,-0.009487443,-0.07846232,-0.017420396,0.099336736,-0.015578337,0.030749086,0.023856314,-0.01596947,-0.04439318,-0.0069216224,-0.02725187,-0.021172749,-0.124731146,0.09525141,-0.10125543,0.0048654745,-0.07353476,0.013846271,0.0032920542,0.010800782,0.040493246,-0.009652244,0.005438803,0.026266437,0.03727805,-0.047160115,-0.07299091,0.057877164,0.043854456,-0.085368,-0.05894052,0.008703754,-0.051874686,-0.010694277,-0.01250964,-0.037768204,0.03789755,-0.046829406,0.044506382,-0.0077569596,-0.043811284,-0.012522605,0.02061011,-0.0218467,0.03400561,-0.015115359,-0.008874204,-0.06340283,-0.027394185,-0.107113905,-0.015610167,-0.067150064,-0.0078455955,0.020880038,0.12592538,0.06485948 +1.4.3.13,"Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5]. Some isoforms can also use [protein]-N(6)-acetyl-L-lysine as substrate deacetamidating the substrate [6]. ",384,1.0,-0.056143742,-0.12699983,-0.060684543,0.008582581,0.08519757,0.030969994,-0.088300265,0.01945027,-0.045594897,0.0017036886,0.050613873,0.057928655,-0.069284946,0.07192075,-0.03983635,0.032306984,-0.13635473,-0.02422211,-0.08315841,-0.040444523,0.054490827,-0.023639662,-0.059231278,-0.04077859,0.063282475,-0.14989768,0.059884083,-0.0153625375,0.009254924,-0.048508868,0.0073979115,-0.06183531,-0.04626669,-0.061884005,0.05293255,0.024905438,0.016504776,-0.043485243,0.04665299,0.031471215,0.047749825,-0.0775696,-0.051631395,-0.042096756,0.0671346,-0.04785227,0.0106302295,0.0058292556,0.045194875,0.06471677,-0.039130438,-0.049573142,-0.031692177,0.02577975,-0.09126914,-0.04502525,-0.14065781,-0.01786812,0.020510642,0.052208096,0.038587112,0.01715754,0.014513404,-0.038335428,0.002787282,-0.09385399,0.05737948,-0.00654637,-0.0031269235,0.044360466,-0.049069267,-0.07726886,0.057429247,0.035260875,-0.03737284,-0.04484228,-0.07238857,-0.009902222,0.0041604345,0.02201605,0.0011449812,0.016511442,-0.013511267,0.12533243,0.04392726,0.017367959,-0.02693951,0.021180274,0.022950826,-0.013888708,0.031417973,-0.01504349,-0.031032586,-0.0020186948,-0.04738942,0.010853772,0.02596477,0.018339347,-0.005044528,0.0011955991,-0.00736439,0.037895333,0.0061683822,-0.02271711,0.012906185,0.004150083,0.012017466,0.11736067,0.011008489,-0.026359608,0.004694267,0.021227067,0.01743594,0.030135134,-0.009450454,0.11093903,-0.03808332,-0.08733962,0.02018294,-0.02055684,0.021092823,0.051545445,0.11133638,0.07158118,-0.10974638,0.058726657,-0.041683964,2.7939025e-33,0.027987933,0.013517962,0.00789475,0.023577522,-0.03361467,0.032998186,-0.11784403,0.013273904,-0.050328843,-0.055873424,-0.051842842,-0.018017951,0.096763276,0.046720557,0.0060163713,0.030228578,-0.0044849575,-0.016571794,0.06684145,0.0049747573,0.016243612,0.03800243,-0.046080448,0.024888786,-0.0042788936,0.040057607,-0.010906127,0.0063205054,0.025064807,0.006679189,-0.03467933,-0.038312484,0.022632385,0.026616564,0.05346466,0.02291904,-0.02003048,-0.0056555574,0.010518289,0.025817037,0.11136499,0.030147875,0.032097578,-0.062046256,0.032371752,-0.0035896741,-0.0324173,0.06425681,-0.03796649,-0.038950987,0.113207966,-0.00601891,0.072851546,-0.060662214,-0.04769328,0.02329832,-0.09687326,-0.017329108,0.004241461,0.033941414,0.034935374,-0.03830092,0.024171904,0.051877048,-0.04265276,-0.0042120833,-0.06140965,0.020605205,-0.028554557,0.014598222,-0.078050725,-0.014474624,0.043940492,0.044870403,0.021305347,-0.04203737,-0.009891281,0.07122484,0.024546308,0.040404882,0.03148479,0.004460744,-0.0722367,-0.014576701,0.019181922,-0.0141207315,0.0096525615,-0.04613269,0.03550516,0.062135898,0.060286496,-0.119676396,-0.07218944,0.09345492,-0.030130753,-4.6550296e-33,0.09546253,-0.08357206,0.029648414,-0.076106116,-0.050303042,0.015288578,0.085016176,-0.027547542,0.026469152,-0.0066971076,0.06404306,-0.01111884,-0.013242893,-0.011456034,0.060276013,0.032017775,-0.04485768,-0.0321856,0.004710204,-0.018947579,0.00067306333,0.036869474,0.07955047,0.023886893,0.10141214,0.030713068,-0.07448225,0.0020022246,0.008971379,0.07390387,-0.069673665,-0.07730972,-0.0154355895,-0.025249783,-0.00479757,0.10070943,-0.0052432753,0.014898354,0.025852054,-0.086053595,0.013773589,-0.006284519,-0.015583107,0.10096409,0.018889496,0.032174572,-0.060903605,-0.017046506,-0.1047951,-0.04276104,0.031371105,-0.053745262,-0.0031347063,0.0029604563,0.002309806,0.05536246,0.024157064,0.053495586,-0.04390021,0.024101226,-0.0108341025,-0.032272298,0.0053198226,-0.079949416,0.07227899,0.03486103,-0.061072357,0.05672221,-0.05495501,-0.010304294,0.06222093,0.007992004,0.062385157,0.05956465,-0.009888931,-0.031560566,-0.019138811,-0.1135609,-0.0831001,-0.037802473,-0.068993516,-0.02507114,-0.032760803,-0.04233407,-0.04472138,-0.023277946,0.07759322,0.13490164,0.043672666,0.012491388,0.04720575,-0.047970954,-0.06765949,0.040896393,0.010767544,-4.3380624e-08,0.016441267,-0.06903413,0.017718617,-0.13600393,-0.05905093,0.021980373,0.021385107,0.014338422,0.043073382,-0.018089395,0.018102149,0.06762183,0.008887312,0.05327114,-0.072887294,-0.02147594,-0.042228937,0.062015645,-0.01810492,-0.030306801,-0.07795448,-0.009113577,-0.028954206,0.085348666,-0.004435119,-0.06847527,-0.012523576,0.049931567,-0.027584955,-0.06806771,0.021191727,0.010655177,0.010750029,0.02875504,-0.08458509,0.098193154,0.006667339,-0.039854057,-0.052218422,0.045650993,0.026698653,-0.039860442,-0.023582224,-0.023728361,0.0870229,-0.0152540775,-0.016856195,0.04977501,0.035717327,0.051679164,-0.010660311,-0.09660232,0.0056991507,-0.074548855,-0.050363854,-0.05201422,-0.04382548,0.010629021,0.072814845,-0.0013869575,-0.029888283,0.028207468,0.18522611,-0.019722568 +1.4.3.14,"Also acts, more slowly, on L-ornithine, L-phenylalanine, L-arginine and L-histidine.",384,1.0,0.0119196,-0.16432914,-0.033081003,-0.012718928,0.0869506,0.05248472,-0.038748793,0.04468754,0.04565354,0.014576902,0.071607664,0.0332101,0.004449871,0.11033467,0.014297947,0.055576205,-0.07515127,0.007941965,-0.04064244,-0.018046303,0.025462586,0.030941205,-0.0055771973,-0.018884875,0.021322852,-0.017433131,-0.023038825,0.00787079,0.03758898,-0.09404323,-0.0013634259,-0.03345662,0.044508167,-0.027820254,0.0010796401,0.040066473,-0.08171624,0.00093244633,0.04278119,0.04463264,0.04572668,-0.05944487,-0.056515656,-0.04160524,0.011828838,-0.004692152,-0.042918712,-0.031850163,0.0156266,0.08254783,-0.042955276,-0.05257325,-0.035852022,0.039804257,-0.07784693,-0.014312859,-0.14892131,0.044282965,0.025809865,0.030433895,-0.062425558,0.021872131,0.02827765,0.033306506,0.020669248,-0.00040704184,0.07250417,-0.068060964,0.028182955,0.020936666,0.060376026,-0.022308305,-0.004137634,0.028800178,0.011773914,-0.11663608,-0.020762308,-0.040140007,-0.03228235,-0.018991683,-0.052294087,0.0017369587,-0.04740723,0.058102824,-0.03718898,-0.017844342,-0.013309753,-0.003626636,-0.028831366,-0.015396613,0.07739634,-0.03443172,-0.083274886,-0.01835573,0.028304437,-0.018205259,0.024154088,-0.0047795586,-0.036832098,-0.026222277,-0.045354918,-0.020090478,-0.119951636,-0.019346433,-0.0034217122,-0.005977396,0.050371468,-0.04785189,-0.09782479,0.028950492,0.044694982,-0.01711398,0.037199765,0.019237742,-0.035959348,0.07565575,0.024378771,0.0047085867,-0.009657641,-0.021571983,0.024964968,-0.04806902,0.030716795,0.0892621,-0.03034946,0.09338447,-0.021442473,4.48936e-34,0.06256466,-0.037591647,0.0059614684,0.0015847742,0.0030190563,0.04838834,-0.04881781,0.036193293,0.09652421,-0.12982675,-0.053148538,-0.05689277,0.061208066,0.039479855,-0.084879465,-0.054377947,-0.0064180195,-0.00617245,0.009762305,-0.0326342,0.019970832,0.089018576,-0.030873427,0.035861798,0.0109447725,-0.029854545,0.027202053,0.002447689,-0.03636683,-0.028544614,-0.0004003976,-0.061112456,-0.028425677,0.021078838,0.029485902,0.106467895,-0.044037677,-0.0027007852,0.035299484,0.00043263534,-0.020222222,0.06111124,-0.098084256,-0.009222936,0.005121702,-0.0030961256,-0.08731185,0.06785637,-0.07707297,0.023902917,0.105837725,-0.043774024,0.004875807,-0.043180496,-0.05018233,0.042598985,0.011690596,-0.034367003,-0.010217794,0.09123927,0.05583907,0.012103614,0.044491827,0.047009617,0.029930959,0.038583595,-0.09231316,-0.04114214,-0.006392695,-0.009280499,-0.075421065,-0.033121936,0.15122996,-0.015006918,0.05542747,-0.017441254,-0.094988346,0.018665062,-0.017836884,-0.01100932,0.0026615667,-0.102408916,0.026926588,0.01872861,-0.033178262,-0.056827657,0.014197925,-0.12445201,0.04010976,0.0038285584,0.0050553093,-0.06661154,-0.014650588,-0.016373899,0.0136835035,-2.3036133e-33,0.03491499,-0.10144469,0.06964141,0.05396009,-0.022217723,0.07451,0.022780947,0.050399616,0.06050892,0.010389995,0.050820798,-0.028160626,-0.08669284,-0.047814317,0.0076958067,0.04750883,0.06222466,0.090697564,0.050610766,0.02359212,-0.079841025,0.052895993,0.023868337,0.07209815,0.08189447,0.033246122,-0.041938752,-0.007899178,0.00535837,0.0332682,-0.029928885,-0.02059939,-0.0735152,-0.112405874,0.00933409,0.07116823,-0.032923132,0.0007053067,-0.044712413,-0.062145054,-0.003928302,-0.062454335,0.10896393,0.043069318,0.011255888,0.02251329,-0.013188145,-0.039864644,-0.124829054,-0.054144487,0.013688328,0.009941846,-0.017174773,0.006388222,0.06490224,0.04411128,-0.010697958,-0.06516925,-0.024734208,0.0067323702,0.007335338,-0.061916564,-0.045123354,-0.0072431783,0.025550034,0.008076375,-0.03149856,0.008442702,0.10620981,-0.034005728,0.030203754,-0.06363384,0.05816632,0.08049254,-0.11104668,-0.06144317,0.021859711,-0.122686185,0.021440107,-0.056989852,-0.08320021,-0.027031304,-0.03467776,-0.033776768,-0.11339925,0.05662635,-0.03139049,0.056898452,0.0037908284,0.06438321,-0.004105947,0.011754993,0.0018409403,0.014720587,0.07782285,-2.9754768e-08,0.08784447,-0.060123697,0.07859485,0.03945485,-0.012280828,3.2226693e-05,0.022997528,0.07773154,-0.00484594,-0.03584251,0.044654977,0.09233709,0.051694553,-0.045529164,0.062449835,0.035388008,-0.0043035722,0.03666493,-0.0133312475,0.024432048,-0.092505984,0.00043424396,-0.034890745,-0.04046405,-0.02850444,-0.033268467,0.038423203,0.120803505,0.049322188,-0.07210309,0.056820765,-0.015167686,-0.0037857634,-0.05157305,-0.009504012,0.05081365,0.04683029,-0.03864687,0.056798767,0.044507187,-0.071029946,0.017586736,-0.020862563,0.030290872,0.0129737705,-0.05892312,0.03815106,-0.027378973,0.050060797,-0.048827473,0.026668169,-0.0101110665,0.008976887,-0.012678823,-0.037944674,0.07645726,-0.062219575,-0.043217737,0.061660755,-0.025927898,0.0016549766,0.02316966,0.12443097,0.06028686 +1.4.3.15,"A flavoprotein (FAD). D-Glutamate and D-aspartate are oxidized at the same rate. Other D-monoaminodicarboxylates, and other D- and L-amino acids, are not oxidized. cf. EC 1.4.3.7, D-glutamate oxidase and EC 1.4.3.1, D-aspartate oxidase.",384,1.0,-0.037562888,-0.13398947,-0.016183361,0.028066855,0.09292522,-0.0031890245,-0.05207658,0.05192324,0.06763679,-0.018864404,-0.0035717487,0.08638505,-0.069754034,0.01374722,-0.04447163,0.00950172,0.0042801285,0.016901381,-0.11253839,0.037519686,0.020270845,0.014536953,0.013474612,-0.036028177,0.1031689,0.020361483,0.031230837,-0.056782864,-0.014876782,-0.037401147,0.07034506,0.008226939,0.03928043,0.024030972,-0.069803625,0.0018407545,0.01266679,-0.04408207,0.026787281,-0.038574208,0.007219554,0.053431477,0.060224563,-0.026890758,-0.00021369687,0.005839587,-0.044633314,0.014171685,-0.049377616,0.029616486,0.078914195,-0.030396566,-0.0933793,0.029540492,-0.034706537,0.0637091,-0.02757067,-0.038740005,-0.024833176,-0.0023400025,-0.038067725,0.02930122,0.074578226,0.008680472,0.021735992,-0.05570864,0.031547446,-0.03730453,0.019903736,-0.09267598,-0.013027593,-0.040674504,0.033880807,0.0019317681,0.025334504,-0.018727416,-0.0011373026,-0.04869075,0.039126143,-0.053562965,0.0795096,-0.018379124,0.06413925,0.050890572,0.04614133,-0.04726899,-0.08909391,-0.0052578053,-0.015740653,0.048997704,-0.0047347355,0.061003916,0.03350705,0.0034436956,-0.07226245,-0.0043740286,0.06174164,0.07278767,-0.09112079,-0.026860297,-0.054802872,0.070275135,-0.07703782,-0.015876615,-0.013823198,-0.038479365,-0.04274094,0.023801694,-0.043549843,-0.03261013,0.04740637,-0.020465659,0.05507036,-0.03287652,-0.0531607,-0.02740106,-0.016920278,-0.061228376,-0.061854146,0.010228904,-0.030468512,0.028840074,0.085104465,0.0720115,0.035344724,-0.0033621818,0.0023165848,1.3841726e-33,0.05646138,-0.05263712,-0.026683057,-0.03311748,0.010847624,0.003826416,-0.021909459,-0.0035103876,0.14297476,-0.04920451,-0.12751825,-0.0060587167,-0.0019667575,-0.0032770522,0.05738627,0.031706385,-0.036695253,-0.054531835,0.05262926,-0.084885724,0.086771764,0.047430452,-0.03783566,0.0631811,0.026164806,-0.06043707,-0.04022873,0.0605718,0.010750615,0.030476928,-0.0724982,-0.068724506,-0.06838899,-0.009547672,-0.066879526,0.032818664,-0.09203789,-0.042968903,-0.06629686,0.033161625,-0.0062421546,-0.005818794,-0.061601672,-0.018938608,0.013126047,-0.035870932,-0.048558325,0.10141095,0.0022187112,0.08861079,0.016491383,-0.06327773,0.09785558,0.026212879,-0.018933695,0.021250589,-0.06327525,-0.029041236,0.09263356,0.07889131,0.011325065,0.044688392,-0.05613388,0.016051492,-0.028064484,0.036336575,0.023466086,-0.03474494,-0.0067258175,0.0417925,0.031504583,-0.035784572,0.08436884,0.049324214,0.014333528,-0.052258108,-0.03618843,0.042214673,0.019443275,-0.009816024,-0.0009856095,0.016826112,-0.06455333,0.023964535,0.0269813,0.061144985,0.023394428,-0.016774254,0.03022902,-0.0050196596,0.03868364,-0.06537187,0.010317629,-0.06078931,0.08994882,-1.2527308e-33,-0.00048549165,-0.022751214,-0.032356653,0.045452703,0.032321356,0.017866202,0.03302892,0.011080147,0.05520649,-0.07205112,-0.024603464,-0.007837092,-0.107517734,-0.0051738177,0.037681423,0.0038217765,-0.06054579,0.058589347,-0.011972246,0.02304291,-0.033021804,0.00076002354,0.035148203,0.06606651,0.10821115,-0.030064212,-0.03660877,-0.038621176,0.03306307,0.086954,0.025093252,0.10810419,-0.043354154,-0.03438015,-0.071118206,0.052389897,-0.054122176,-0.019092655,-0.056679092,0.051041402,-0.011727957,0.072086945,0.03224593,0.0768594,0.0584044,0.018816877,-0.11131956,-0.02146764,0.08686577,-0.075973645,0.017122336,0.0068729213,0.009455898,0.0134492675,0.06815599,0.02934444,0.08657059,0.041999154,-0.033786174,0.00849135,-0.039976913,-0.112588294,0.02406928,-0.058915216,0.034783076,0.019446684,0.056775298,0.11428996,0.038984418,0.003215745,0.059558928,-0.056776293,0.03456882,0.019120002,0.03273301,-0.108319916,-0.03355752,0.12084948,0.045173455,0.020728676,-0.0041131033,0.012338336,-0.01682416,0.01567486,-0.09588604,-0.113305055,-0.029663967,0.05401,0.016382307,0.048701234,-0.05960175,-0.0073620635,0.06250155,0.014841228,0.063885786,-3.7310738e-08,0.036557633,-0.006894304,0.04392835,0.022362128,0.10262668,0.08240579,-0.076688886,-0.022726428,0.0030804512,-0.047144618,0.023188958,0.13240471,-0.07166506,-0.048533726,0.004879787,-0.009268939,-0.030599216,0.03402073,-0.024626669,0.04435495,-0.04415142,0.05864547,-0.07274219,0.013880859,-0.0064682015,0.01583223,0.026655773,-0.062312547,0.021805814,0.022840224,0.02352866,0.030095397,0.052472543,-0.08565314,-0.10204151,-0.07239554,0.10866434,-0.01793017,-0.044888422,0.02873173,-0.09237793,-0.045322966,-0.0023134097,0.015893254,0.048313133,-0.0104213515,0.033205822,-0.01948376,-0.07882968,-0.043495256,0.013582729,-0.054633196,-0.03088139,-0.04149792,-0.088449255,-0.01442855,-0.032354787,-0.052256364,-0.026074117,-0.0979631,0.0126502905,0.056827772,0.12647569,0.025320552 +1.4.3.16,"A flavoprotein (FAD). L-Aspartate oxidase catalyses the first step in the de novo biosynthesis of NAD+ in some bacteria. O2 can be replaced by fumarate as electron acceptor, yielding succinate [5]. The ability of the enzyme to use both O2 and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions [5]. Iminosuccinate can either be hydrolysed to form oxaloacetate and NH3 or can be used by EC 2.5.1.72, quinolinate synthase, in the production of quinolinate. The enzyme is a member of the succinate dehydrogenase/fumarate-reductase family of enzymes [5]. ",384,1.0,-0.06763575,-0.009870279,-0.11403858,-0.012952916,0.13325211,-0.003123708,-0.046331815,0.058664717,0.025771856,-0.00537896,-0.023100823,0.0018793672,-0.08383928,-0.026766803,-0.12361119,0.046926454,-0.010054957,-0.040808734,0.0078319805,-0.026264424,0.05682502,-0.03837629,-0.016964242,-0.02768085,0.08124114,0.0040946323,-0.0034337714,-0.014289092,-0.07884269,-0.03742557,0.004063286,-0.0039613303,0.07029221,-0.0454945,-0.04908509,0.08157172,0.018800862,-0.030460931,0.03103556,-0.009870012,0.0053046895,0.009969314,0.020532236,0.02041914,0.064507894,0.024160372,0.020309867,0.07245445,-0.012802216,0.044725817,-0.09860557,-0.06082264,-0.08217558,0.020196006,0.021924919,0.044899672,-0.016313182,-0.028713634,-0.03637729,0.05079684,-0.0027499434,-0.027975727,0.01832759,-0.029077448,0.0078068096,-0.07225244,-0.017557085,-0.013600275,-0.0148504255,-0.043062612,-0.042575337,-0.009571208,0.017708087,0.021053119,0.015714625,0.108840235,-0.02223852,-0.025254382,0.03544841,0.034594335,0.058328707,-5.362087e-05,0.042205434,0.03645611,0.074148394,-0.03781447,-0.0030705025,-0.017483594,0.03621483,0.082332075,0.0036372656,0.010072308,0.015761107,-0.009468004,-0.07916889,0.08399585,0.015807515,0.029114228,0.024399927,-0.06501907,-0.02681912,0.033591703,0.024995012,-0.059453446,-0.082452126,-0.018308518,0.014689687,0.08913188,0.025822558,0.019637326,-0.024770707,-0.024414824,0.032740124,-0.06614765,0.011098331,0.10528668,0.019196818,-0.0668806,-0.0790263,-0.03338256,-0.026643828,0.06541889,0.07950111,0.04158524,0.008141143,0.0043495386,-0.09590908,5.6881077e-33,0.070189856,0.036109153,-0.012552245,0.0540303,-0.031223617,-0.018675711,-0.07862519,-0.003355119,0.002095376,-0.040690403,-0.04906637,-0.047369633,0.038567763,-0.040517353,0.019686434,-0.014742195,0.009217911,-0.08204915,0.032038074,0.0005011719,0.034011424,0.02257124,-0.02974583,0.014769234,0.04397983,0.054252654,-0.00460923,0.05136409,0.036583412,0.006899572,0.0339918,-0.10101196,-0.09989246,-0.015049999,0.0046356744,-0.022297291,-0.09716217,-0.025710441,-0.09520302,0.07827601,-0.018263394,0.08269226,0.007753783,-0.029938517,0.05545292,-0.051246762,-0.011167006,0.11318871,0.08538269,0.065651245,-0.0008352585,-0.024809364,0.11852488,0.00427586,-0.036301438,0.040302843,-0.022502359,0.037888568,0.039985765,0.031108798,-0.025498046,0.04849369,-0.018425995,0.043856878,-0.08801424,0.0297574,-0.08394788,-0.081318535,0.06768787,0.12946852,0.009308061,-0.06748124,0.026374081,0.018132022,0.028148565,-0.06566161,-0.008370073,-0.025602601,-0.031109272,-0.011816962,0.061473813,-0.011002874,-0.02383615,-0.023219896,0.0027936234,0.014064937,-0.020554656,-0.0021888835,0.023143332,0.050311945,0.025538666,-0.055906765,0.009812284,-0.010800292,0.023878518,-5.2178964e-33,0.10831082,-0.12627418,0.030750146,-0.05141026,-0.050536275,0.105988845,-0.0005437401,-0.041004777,-0.006497934,-0.09920764,-0.020122256,-0.05220956,0.065113954,0.0013594206,0.004432534,-0.03628651,-0.06001497,0.030407207,0.007904007,0.018248226,-0.02429094,0.09494992,0.07712058,0.01658027,0.06799521,0.020084234,-0.00596849,0.035749376,-0.0010138298,0.052595332,-0.06778003,-0.011385375,-0.034657095,-0.024027502,-0.026774177,0.011884444,-0.0068495027,-0.018999733,-0.013154702,0.047044795,-0.012451608,0.055634372,0.039539862,0.050313678,0.003425345,0.034243576,-0.11728485,0.04061904,0.03613745,-0.008003439,0.037209526,-0.037322786,-0.08497007,0.048934605,0.09283283,-0.002050124,-0.0041676597,0.045250192,0.006406339,-0.017989699,-0.039830063,-0.1375809,0.029247008,-0.08758059,0.08685516,0.07381258,-0.021195028,0.13455084,-0.0152994245,0.045422237,0.04881065,0.016123872,-0.0054098787,0.048683584,0.051599946,-0.015231023,-0.05691902,0.051909905,-0.01637434,0.028501382,-0.030128075,-0.02343023,-0.028882137,-0.024011772,-0.057471834,-0.11034839,0.0378281,0.054775123,-0.0072867256,0.022734363,-0.021081898,0.003121839,-0.0182617,0.031810064,0.04886033,-4.653911e-08,-0.0037332405,-0.060560204,0.060866926,0.023557033,0.023427213,0.042471193,-0.04260177,-0.06580556,0.04364645,0.005097051,-0.02317995,0.1363597,0.03775524,-0.010687652,0.024313109,-0.04605032,-0.014153068,0.05571302,-0.036299523,0.06389914,-0.028953135,0.0027615183,-0.15429874,0.06825031,0.048202686,-0.076686665,0.005423515,-0.09484363,0.022552673,-0.02511109,-0.047951113,0.03339127,0.097108334,-0.05644622,-0.162911,0.013466641,0.015548678,-0.026371894,-0.07721492,0.0076369876,0.008525893,-0.02168372,-0.07189748,-0.008175049,-0.03593353,0.00012879114,0.062177256,-0.016767288,-0.089443944,-0.015900549,0.014704204,-0.053882185,0.04381872,-0.01654847,-0.08356725,0.002717656,0.0018841499,-0.046695977,0.009830331,-0.052835,0.01610796,0.006091618,0.17681694,-0.018755484 +1.4.3.19,"A flavoenzyme containing non-covalently bound FAD. The enzyme from Bacillus subtilis is active with glycine, sarcosine, N-ethylglycine, D-alanine, D-alpha-aminobutyrate, D-proline, D-pipecolate and N-methyl-D-alanine. It differs from EC 1.4.3.3, D-amino-acid oxidase, due to its activity on sarcosine and D-pipecolate. The intermediate 2-iminoacetate is used directly by EC 2.8.1.10, thiazole synthase.",384,0.99999994,-0.06366234,-0.09568303,-0.08854904,-0.03927698,0.06746116,0.00846719,-0.067623466,0.09655324,0.048984453,-0.013925151,-0.025361694,-0.012817317,-0.010051001,0.072122246,-0.08017611,0.034595814,-0.03478482,0.04116695,-0.044334468,-0.052667577,0.061001934,0.057059728,0.046988234,-0.026491018,0.01913765,-0.013703771,0.09297656,-0.08895793,-0.042038605,-0.029072665,-0.01305774,-0.016189706,0.07979768,-0.06618129,0.029327853,0.031089261,0.06538829,-0.032842387,0.1060049,-0.0024896918,0.019503718,0.037468825,0.044241108,-0.08960912,0.03794134,0.02357364,0.014570826,0.0034225013,0.0054989727,0.021802535,-0.078856066,-0.041696467,-0.04913094,0.042755667,-0.02605454,0.02754516,-0.06289137,-0.029665671,0.0006230946,0.038658585,0.04520122,-0.0043268604,0.08150356,-0.022385305,-0.014222284,-0.041861936,-0.04216739,-0.02324358,-0.021687156,-0.014291324,-0.06620732,-0.023468195,-0.059403706,0.023304394,0.061590288,0.011158498,-0.016170163,-0.0024830906,0.027369088,-0.04206154,0.025548663,-0.061844792,0.041150007,0.13193172,0.04244696,-0.0064708977,0.0653598,0.013663621,0.057290655,0.06338229,0.033299785,0.022051023,0.031531855,0.018263998,-0.030035049,-0.019391976,-0.011819164,0.0944106,-0.0011244982,-0.04801192,-0.018645443,0.008132091,0.01545549,-0.002034355,-0.043099847,-0.068465844,0.027586456,0.04258472,0.043571874,-0.0007554625,0.020816902,0.004378989,0.037112866,-0.11090843,-0.0023584452,0.03382616,0.0007619923,-0.028792014,-0.038000803,-0.061776202,0.0030793794,0.025237849,0.08655772,0.09078003,0.028639894,0.01871291,-0.11281472,2.224765e-33,0.060606577,0.05845845,0.023106845,-0.0018435294,0.0544939,-0.038558904,-0.061137024,0.017304221,-0.04149001,-0.023618072,-0.12953188,-0.015054023,0.010770313,0.025383666,0.054450728,0.010818247,0.016559882,-0.07384532,0.047786877,-0.05235008,0.07169124,-0.0102190515,0.008136137,0.053796753,0.03850998,-0.035487406,0.060170144,0.072584644,0.04776664,-0.015433177,-0.01747148,-0.12505662,-0.047645807,-0.035916526,-0.03250154,-0.00085679657,-0.109066196,-0.007361671,-0.07436514,0.06611348,0.02781282,0.025939286,0.016161872,-0.02860215,0.030456979,-0.06006758,-0.08290781,0.11192033,0.046085488,0.07506943,0.013392065,-0.018635081,0.10461209,0.014161531,-0.028622467,-0.012426557,-0.01956238,0.04148413,0.053081844,0.021284176,-0.0008516694,0.019475872,0.0050349566,0.12151098,-0.09008822,0.095263354,-0.037504587,-0.033963848,0.023811458,0.043795012,-0.016262932,-0.035300102,0.05185199,0.00047115085,0.02409586,-0.09372345,-0.08069061,-0.07125179,0.02543147,0.02967709,0.02031166,-0.005781466,-0.025990376,0.027505077,-0.06749461,-0.003142481,-0.048759583,0.0059716734,0.028721977,0.080514506,0.027824344,-0.12809066,-0.048314553,0.0811518,0.03772767,-1.46370435e-33,0.115052484,-0.08263626,0.039448015,-0.06429608,-0.06378964,-0.020044964,0.04871513,-0.00019162701,0.077282146,-0.057634953,0.035033785,-0.044132713,0.002032447,0.012479365,-0.032765266,0.011845634,0.0073705628,0.01973198,0.039395723,-0.024602637,-0.034703355,0.03414464,0.020371094,-0.022062948,0.016250605,0.0457606,0.029941894,0.08685222,-0.02163963,0.007194306,-0.0481456,0.03448131,-0.06975097,-0.077079915,-0.091663495,0.07550941,-0.010230976,-0.03583819,0.020315139,-0.008279049,-0.034791905,0.042436592,-0.0064036814,0.094193295,0.061468862,0.115204066,-0.02235946,-0.014955271,0.012620475,-0.0728913,-0.003671666,-0.022696126,0.0429386,0.0040400065,0.067873344,0.02468243,-0.037719004,0.1015312,-0.04049034,-0.05858463,0.0033075046,-0.10251334,0.06870219,-0.055832677,0.0428657,0.11592251,-0.05274684,0.09986322,0.078266375,-0.0044392045,0.07770711,-0.011553974,0.028408846,0.06400902,-0.0042398106,0.004020093,-0.06339881,0.041520324,-0.0021516394,-0.011139857,-0.010943529,-0.033090577,-0.055207774,-0.025192225,-0.06646446,-0.047442954,0.04169888,0.08538592,-0.0009099543,0.034347292,-0.030923162,0.02405078,0.020886922,0.0064006075,0.043208696,-4.830257e-08,0.06299644,-0.08736059,-0.014545501,-0.009344874,0.07025459,0.05015613,-0.012840825,0.015186612,0.036774237,-0.069583185,-0.09642877,0.08420999,-0.025719907,0.02858785,-0.0003158601,0.012006727,-0.070500135,-0.0028636097,-0.015305112,0.0014885487,-0.05867186,0.07510527,-0.12969723,0.01278159,-0.014571941,-0.075287044,0.017385596,-0.0591097,-0.033336237,-0.030961204,-0.014124456,0.045506123,0.032551583,-0.04325653,-0.09746656,-0.020657456,-0.024957493,0.011960096,-0.06388373,0.00036904222,0.04404331,-0.011187409,-0.070232615,0.0029179626,0.033780273,0.0044366117,-0.05072047,0.034480855,-0.030879874,-0.06857623,0.04881056,0.013600729,0.016427392,-0.055268448,-0.07474458,0.021670312,0.01425488,-0.06471997,-0.0434587,-0.021156648,-0.054664582,-0.036513817,0.15369773,-0.02642804 +1.4.4.2,"A pyridoxal-phosphate protein. A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10, aminomethyltransferase), the L protein (EC 1.8.1.4, dihydrolipoyl dehydrogenase) and the lipoyl-bearing H protein [3]. Previously known as glycine synthase.",384,0.99999994,-0.025626624,-0.07203491,-0.059148416,-0.0985212,0.03505443,0.031130614,0.008321959,0.04967232,0.054933738,0.005076317,0.057646766,0.07256651,-0.027152546,0.08056629,-0.020277794,-0.034869906,-0.043896552,-0.005232688,0.02163716,-0.075273775,0.029369723,0.0814445,0.009835204,-0.005388305,0.00061647187,0.041425087,0.009741592,0.012258196,0.032394774,-0.002870912,-0.03201315,-0.047346223,-0.0020492282,-0.07397514,0.020271553,0.10976332,-0.06334962,-0.008765523,0.03407669,-0.0031751066,0.078673415,-0.050488174,-0.043276306,0.007658237,-0.033812214,0.04007828,0.088389486,0.03272528,-0.0056667374,-0.017059453,-0.04820375,-0.032723513,-0.085825466,-0.01175846,-0.012891009,0.011188705,-0.02336584,0.040008634,-0.056392983,-0.059783723,-0.041456822,0.03314695,0.03131473,0.002240737,0.09383001,-0.032805648,0.03255607,-0.04509283,-0.010987039,0.014471015,-0.035973497,-0.054033954,0.0386405,0.026246032,-0.08057624,0.0630343,-0.08068263,0.01717952,0.015543843,0.0033938321,0.03627433,-0.0032333925,-0.014644443,0.053491548,0.017156214,-0.0004127593,-0.020271897,0.034963086,0.0013150068,-0.04614711,0.003910579,-0.04218844,0.046581015,0.033287045,0.0044052424,0.049450785,-0.0055121677,-0.066243775,-0.015792642,-0.047956422,-0.043316305,0.041230123,0.018388208,-0.024156952,-0.082899906,0.027026607,-0.096196234,0.055654377,-0.017309085,-0.041768514,-0.05789272,0.0314151,0.013335843,-0.022945307,0.04122359,0.04634092,0.054792915,0.023506587,0.014919437,-0.00074773753,0.026381953,-0.016648006,0.05672245,0.12235015,0.010655226,-0.0007899139,-0.11423631,-4.6466176e-34,0.1027868,0.061831716,0.04006836,0.03494124,-0.03807109,-0.00413591,-0.049572162,-0.013690897,-0.026558055,0.013602617,-0.049556233,-0.060658365,0.06836595,0.03968218,-0.042443365,-0.0062831095,-0.04479265,0.07457754,0.071904406,0.002433524,-0.016909264,0.09201812,0.015750198,0.059131723,0.026979238,0.090487696,-0.030670386,-0.026494693,-0.033971645,-0.0035611521,-0.060128085,-0.09020312,-0.11251503,-0.015572932,0.036463648,-0.1170337,-0.035110097,-0.101515345,0.044375177,0.020253805,-0.008744369,-0.092462964,-0.012341556,-0.02226667,0.02515686,0.0013137116,-0.014058463,0.017380483,-0.04494721,-0.012134477,0.0727109,-0.07171639,0.08215638,-0.047353875,-0.15960416,-0.022049613,-0.033711866,0.016593998,-0.0029511328,0.11126057,0.035550147,0.03523501,-0.053581562,-0.024736544,-0.023932675,-0.035337217,-0.06235311,-0.05034759,0.049641978,0.08732835,0.027654096,-0.024724217,0.08663102,0.057498485,0.020280728,-0.044601988,-0.016376603,0.03178618,-0.0041487846,0.07072486,-0.07104727,0.012311867,-0.067268945,-0.07312013,-0.06363269,-0.012871598,0.05115254,-0.14363502,0.021606224,-0.00333029,-0.0030319015,-0.051095612,-0.053273965,0.04243923,-0.041937653,-9.472587e-34,0.05034629,-0.10299502,0.05770921,-0.019484214,-0.041038994,-0.017415233,0.06532665,0.014564671,0.05565674,0.021136893,0.051187143,-0.03181739,-0.01631975,-0.07310251,-0.009008667,0.028060129,-0.039161418,-0.03038966,0.04332452,0.0057541495,-0.00048297664,-0.0156472,0.047855943,0.040079296,0.05114882,0.093804196,-0.00045412604,0.06471581,-0.00042950842,0.07316667,-0.04215639,0.046070177,-0.012952954,-0.024688154,-0.094471864,0.053454675,-0.057557534,-0.0023971756,0.01910381,-0.05472075,0.054673407,0.08211235,0.06784928,0.02026946,0.017900543,0.039721597,0.019492619,0.0102623375,-0.009417778,-0.05441825,0.027760826,0.054613076,0.02306474,0.033187635,0.010743646,0.035277713,-0.0057438817,0.033402853,0.026278583,0.031507105,0.0066787205,-0.092633136,0.023314819,0.11315619,0.048514485,0.024627035,0.045709226,-0.0022919208,0.08578141,0.081428684,0.06886996,-0.025517875,0.07933461,0.10738084,0.033649128,0.010172866,-0.06427096,0.027945003,0.013144897,-0.04657319,-0.052638948,-0.015087399,-0.05202584,-0.06432596,0.029606024,-0.08617081,0.011399494,0.15463342,0.050561257,-0.0141394185,-0.0048057493,0.0023992402,-0.05309889,0.118914835,0.07106799,-4.501505e-08,0.062221844,-0.06852751,0.0026992662,-0.059520792,0.023633305,0.03034309,0.037492618,0.0040462567,0.08520959,-0.02530339,-0.008562366,-0.022408348,-0.024642333,-0.04952778,-0.02471474,0.10037733,-0.07818043,0.035997294,0.0008974247,-0.05115336,-0.01495408,0.029078946,-0.10614359,-0.0012128473,0.026606828,-0.017219093,-0.05090164,0.029441802,-0.0010435405,-0.048396282,0.014591438,-0.0062880297,0.018822664,-0.031732723,-0.03608029,0.055835128,-0.024318945,-0.036834225,-0.03803218,0.024426362,-0.081304036,0.0029057732,-0.02423777,-0.023765614,0.028219895,0.04540642,-0.06453428,0.036983732,-0.021530652,-0.018027294,0.027943378,0.06365393,-0.05766952,-0.09730874,-0.14973281,0.016030442,-0.026638241,-0.06408123,-0.009208554,-0.11181883,-0.037974495,-0.012066905,0.14751932,-0.053352028 +1.4.7.1,"Binds a [3Fe-4S] cluster as well as FAD and FMN. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate. The NH3 is channeled through a 24 A channel in the active protein. No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein [5,6].",384,0.99999994,0.0067166183,-0.116867304,-0.08720473,-0.030211437,0.07024599,-0.013528648,0.021823578,0.020978963,0.007571289,-0.067479946,-0.007924392,-0.03603249,-0.011000129,0.06349332,-0.04065138,-0.0218712,-0.11220645,-0.04835961,-0.06536254,-0.036927275,0.06315459,0.06052146,-0.020087106,-0.07634504,-0.034647707,0.026235258,0.06785074,-0.049830783,0.042513162,-0.09073503,-0.01360952,-0.028508691,0.019425713,-0.0139964055,-0.005349165,0.05468019,-0.00037806458,-0.0494722,0.046614844,0.01190683,-0.001519383,0.0091773225,0.03940908,-0.09209158,-0.003438769,0.012222873,0.01643146,-0.0031477138,0.03398958,0.0071938597,0.009226677,-0.05007329,-0.028557263,0.13939102,-0.015287684,0.040436886,-0.12748562,-4.6876437e-05,-0.04866855,0.08346275,0.0029480248,0.03700663,0.018654134,-0.02272116,0.14494653,-0.029209157,0.026878282,-0.057374373,0.026633268,-0.019837826,-0.03024268,-0.023409955,0.039232165,-0.046428934,0.024270177,0.020061018,0.027729144,0.026404835,0.059080243,-0.024755646,0.023409853,-0.020529013,0.10331179,0.13211538,-0.02474643,-0.03640857,-0.082947314,-0.04321121,-0.0023082264,0.034706686,-0.04594248,0.019221518,-0.028704012,0.020449996,-0.036722224,0.016782936,0.014811022,-0.0070954873,-0.0077714683,0.05942749,-0.024376899,0.07069871,-0.03283711,-0.039392795,-0.02252712,0.03228656,-0.03338841,0.118241854,-0.0135814855,0.029384244,0.032128017,0.074767336,0.07206057,-0.0159142,-0.06807196,0.033730302,0.03696604,-0.07463374,-0.033635598,-0.03894557,0.012357838,0.032885745,0.02400771,0.05523044,-0.037266392,0.023470176,-0.10437537,3.972848e-33,0.060261827,-0.043466143,0.0011818802,-0.006438674,-0.014524773,0.016620122,-0.06892614,-0.048841696,0.057217035,0.013549061,-0.09630265,-0.022505555,0.06320515,-0.037836112,-0.042720977,-0.030225646,-0.08634373,-0.031045245,0.024220726,-0.03004918,0.04537607,0.10540207,-0.045181137,-0.017497692,0.004469293,0.06383775,-0.021310683,0.0024239614,0.010722716,0.022403302,-0.019986592,-0.0689086,-0.08939538,0.0054582665,0.013451742,0.007689432,-0.027560337,-0.070306115,-0.026387913,0.027224742,0.024753354,0.01600227,-0.0639354,-0.07164134,0.048812076,-0.043409176,-0.043801244,0.072128855,-0.009384642,0.09928907,0.049203776,-0.10432322,0.045543905,-0.00013535543,-0.04981437,-0.044047307,-0.055811193,-0.010831532,0.07738226,0.09883786,-0.0038110819,-0.014033824,-0.04823901,0.045658145,0.029041141,0.085173264,-0.012268727,-0.031860203,0.064379476,0.04329382,-0.061906315,0.019902498,0.07466258,0.01835564,-0.0323787,-0.06789416,-0.038276136,0.027317764,0.033906773,0.07645658,0.06636335,-0.033068683,-0.001267117,0.03592324,-0.061843283,-0.047395863,0.030608255,-0.10478902,-0.025714569,-0.018618224,0.05147843,0.0063428897,0.028472684,0.032727394,-0.005193158,-4.9421746e-33,0.087493226,-0.07654406,0.0038660185,-0.029605005,-0.05234155,0.02102239,0.025957877,0.002237015,-0.027585166,0.018542876,0.07664636,-0.006519994,-0.022229971,-0.03725226,0.013128848,0.0012513612,-0.037503067,-0.0108910855,0.0395749,0.047874074,0.0012852035,0.04260952,0.008530162,0.12731205,0.03975319,0.017985983,0.0025036035,-0.010232569,-0.005536641,0.05902661,-0.0069955564,-0.077808514,-0.018281935,-0.07268654,0.005010965,-0.028095037,0.00016623485,-0.012568135,0.0016943563,-0.06011589,0.04696658,0.0863769,0.02721551,0.0831199,-0.0019832542,0.12743177,-0.0584722,-0.0033010703,-0.029712763,-0.006947584,0.023804856,-0.07620478,-0.017239777,-0.042341076,0.0055028345,0.018801924,0.08627017,0.004777053,0.00542098,0.0716088,-0.012355326,-0.14998029,0.010690093,-0.017511386,0.055500038,0.034204114,0.024208723,0.09857375,0.02776169,0.080679715,0.03064383,-0.03487611,0.13311797,0.021706494,0.031567205,-0.021220831,-0.0063592377,-0.026504073,-0.015125718,-0.05894437,0.005948156,0.03031965,-0.009587362,-0.04588269,0.06146701,-0.031239338,0.05754261,0.11514208,0.027743965,-0.010868309,0.0038699207,0.04382889,-0.036812704,-0.013708231,0.0766083,-4.4716856e-08,0.04386306,-0.068485275,-0.0032039103,-0.024773864,-0.069807805,0.1195978,0.004211074,0.042264704,0.004495354,-0.012564086,0.052545194,0.09562114,-0.089515306,-0.0532359,0.020970661,-0.05328594,-0.09929953,0.0373875,-0.055764344,-0.051477574,-0.10952377,0.006951969,-0.08579987,0.01414417,0.04611807,-0.06564104,0.015594706,0.011699511,0.0019766951,-0.04641663,-0.010341394,0.055234026,0.006281091,-0.036560144,-0.18584515,-0.019906081,-0.005861159,0.012806933,-0.08678555,0.01887993,-0.042359866,0.03913108,-0.016680175,-0.04169968,-0.004070078,0.027175512,-0.0054254467,0.05230556,-0.033045467,-0.010951769,0.018306157,-0.038255937,0.055317525,-0.024043454,-0.11715307,-0.03645931,-0.11428445,-0.023906158,0.04693043,-0.047571335,-0.04547823,0.018021865,0.06627752,0.01574127 +1.4.99.1,"A flavoprotein (FAD). Acts to some extent on all D-amino acids, except D-aspartate and D-glutamate.",384,1.0,-0.0655911,-0.12620217,-0.06550262,-0.0061347308,0.08490712,0.03279695,0.017814836,0.06271107,0.05765947,-0.0035302776,-0.014545901,0.056795705,-0.08033885,0.010326663,-0.038559724,0.018627193,-0.045114405,-0.014462658,-0.10223756,-0.011916114,-0.018824594,0.0427976,0.026706973,-0.054863628,0.0039639734,0.006325029,0.057611298,-0.059647065,-0.009327676,-0.013445182,0.069372065,0.023090752,0.05610304,0.04401274,-0.0455519,0.040122885,0.019314516,-0.030275391,0.0010489846,-0.009716877,0.051111963,0.022155395,0.07569978,-0.036836863,0.053947642,-0.007142289,-0.04251538,0.07160723,-0.014933014,0.052257217,0.02602359,-0.058741126,-0.08802432,0.051544573,-0.0059244675,0.07183568,-0.01087044,-0.04279283,-0.020901946,0.013433761,-0.031671304,-0.0071694786,0.08157336,0.016386788,0.0753299,-0.052702975,-0.036584184,-0.005009703,0.060936335,-0.05414978,0.015468802,-0.025899734,-0.03029385,0.060738806,0.06633951,0.0007666379,-0.058845453,-0.030025706,0.06919066,-0.047415797,0.10869424,0.015371658,0.09359373,0.0776091,0.04259341,-0.03995033,-0.02916376,0.012572768,-0.033847686,0.068819076,-0.033311788,-0.0022324282,-0.007227974,-0.0001429094,-0.095681146,0.028501324,0.04450674,-0.06678059,-0.108348556,-0.0028696286,-0.06342488,0.023830066,0.0053453604,0.012600905,-0.073872775,-0.050477307,-0.062467214,0.008750538,-0.07545896,-0.083038,0.004102089,-0.039779045,0.04748544,-0.05057596,-0.018839516,-0.044052858,0.01005497,-0.050300512,-0.03442511,-0.041050624,-0.061974436,0.096617505,0.07605337,0.112436354,0.03076347,0.019055339,-0.083491325,2.2867168e-35,0.07169148,-0.052275103,-0.03227004,3.2600315e-06,0.02137939,-0.021955645,-0.0361816,-0.0086646965,0.08328227,-0.02280491,-0.046136983,-0.0027942774,0.02381095,-0.012406398,0.056385584,0.040679596,-0.0323708,-0.040855292,0.05750953,-0.11056828,0.039951574,0.087866046,-0.0062931296,0.042619888,0.017409584,-0.03436253,-0.07928268,0.05142726,0.029381836,0.029946465,-0.07826157,-0.046208672,-0.072874874,-0.0072894203,-0.013938876,0.05379199,-0.0776827,-0.090697765,-0.07728338,0.05727084,-0.001667583,-0.049687058,-0.08127769,0.0098392,-0.0048425626,-0.004007985,-0.06596289,0.07488925,-0.02793847,0.094230145,0.063235745,-0.08809577,0.13252409,0.049451858,-0.09379172,0.016306685,-0.0649303,-0.03798222,0.046443835,0.04131842,-0.005892085,0.013751101,-0.035707902,0.07037569,-0.07074343,-0.023135465,-0.021934953,-0.06749378,0.013490178,0.090109296,0.027977305,-0.036195807,0.09496127,0.010847,0.03951994,-0.058399066,-0.024871092,-0.031448606,-0.024620052,0.02337215,-0.004265015,-0.03164516,-0.020288402,-0.008449797,-0.007511014,0.02959879,0.0074767,-0.088865966,-0.0013072243,-0.045559842,0.0017428594,-0.028378535,0.005871321,-0.00247701,0.0662844,-8.755701e-34,-0.005511602,-0.102778286,-0.017792072,0.084990025,0.0076970668,0.017615179,0.047515567,-0.02710305,0.03438465,-0.062020954,0.0039989096,-0.068161726,-0.062784515,0.011992243,0.028662182,0.028689716,-0.07686143,0.03789305,0.031046502,0.039917223,-0.061590035,-0.03932892,0.0653386,0.09674052,0.06324791,-0.009548142,0.01604265,-0.038521484,0.01058401,0.054857213,0.01569267,0.063697375,-0.056204684,-0.030958844,-0.07030635,0.034468032,0.017082484,-0.02013615,-0.04446405,0.016369801,-0.01579366,0.05004815,0.056696203,0.06473625,0.05241234,0.06305704,-0.0069116303,0.058925025,0.009720304,-0.05606848,0.01442067,-0.008789367,0.062689826,0.07404479,0.043024823,0.055684354,0.107883625,0.05968268,-0.026828613,0.03635065,-0.012983329,-0.14706257,-0.008797016,-0.010343004,0.08150315,0.03652867,0.0684699,0.108706884,0.004021766,0.023306318,0.11967667,-0.033146407,0.035617158,0.06923027,0.019824233,-0.053298954,-0.02971861,0.08625212,0.037690323,0.027876697,-0.020554524,0.006980599,-0.0073495307,0.025768105,-0.06602541,-0.13240549,-0.01823416,0.065179914,0.015807576,0.055190217,-0.060903247,0.039060127,0.01045255,-0.03975365,0.045791812,-2.8236112e-08,0.043656647,-0.014612048,-0.0106031615,0.005162003,0.11065386,0.031652268,-0.051619407,-0.022539673,-0.014919381,-0.038871713,-0.03130857,0.11907641,-0.057869222,-0.010079523,0.03418096,-0.010431537,-0.0017412303,0.041208077,-0.04481954,-0.009664218,-0.050193653,0.056312826,-0.08721873,-0.008020128,-0.053651974,-0.028317878,0.0046791956,0.011223325,0.06376359,-0.009000099,0.025089044,0.006463759,0.031274952,-0.074887805,-0.090242386,0.028239924,0.06066523,-0.09219659,-0.016180228,0.044007994,-0.077272356,0.010900135,0.014254429,-0.028580448,-0.031093579,-0.012473831,0.028070884,-0.004979538,-0.065615185,-0.006908851,-0.007814731,-0.001156157,-0.009324818,0.014836288,-0.0938187,-0.03303995,-0.030962,-0.069899,0.0020849858,-0.102680966,-0.010883811,0.064703606,0.05487364,0.050173458 +1.4.99.3,A quinoprotein.,384,1.0,-0.026808793,0.0089054415,-0.0065810955,-0.009748162,-0.013398741,-0.032459147,0.17527722,0.07089106,0.072509624,0.057045847,0.049330775,-0.01800541,-0.04548517,0.012345441,-0.020670475,0.057696097,-0.01729245,0.016466727,-0.028861616,-0.03108936,-0.07035824,0.024703642,-0.05874439,0.013062397,-0.0028670526,0.011542782,0.0073006256,0.011913794,-0.027451688,-0.0380117,-0.054480743,-0.002668249,0.010860843,0.0096198395,-0.008538235,0.09911593,-0.00903653,0.005145776,0.04339848,0.024374528,0.03496398,-0.002736288,-0.006532573,0.021856122,0.024961838,0.05669325,3.9088744e-05,0.15358242,0.020841293,0.09234599,-0.11214831,-0.09856754,-0.060303643,0.063322335,-0.019072736,0.031417623,-0.07937592,-0.0014472583,-0.021217156,0.062281527,-0.0062075313,-0.01974554,-0.01791249,0.011490769,0.0886107,-0.04695351,0.0150054,-0.021168351,-0.020640528,0.09986615,0.10051869,0.0290119,0.025294142,0.013664712,-0.014042544,-0.0699384,-0.036903728,-0.052573908,0.072463185,0.008095576,-0.0034590603,0.07959945,-0.007734378,0.06419744,0.021150853,0.015456669,0.09956308,0.0143097695,-0.083449155,0.0046700714,-0.011585035,-0.06463083,-0.0014149777,-0.08834353,-0.018556984,0.071275294,-0.036231004,-0.090200454,0.02044473,0.09043183,-0.013430053,-0.039596472,0.024776202,-0.086718164,-0.10053452,-0.002579382,-0.065946236,0.008580238,0.041490052,0.072630204,-0.04010952,-0.040914968,0.030739166,-0.051346827,-0.008599552,0.03815223,0.048630435,-0.061296586,0.054317635,0.011062304,-0.005649343,0.04695346,0.023533018,0.062886916,-0.004370474,-0.01702801,-0.065918915,-2.9910373e-33,0.03053904,-0.01791832,0.04192064,0.10629851,-0.041236073,0.068298206,-0.042778086,-0.013041179,-0.09833544,-0.06579225,-0.10802029,-0.041604355,0.023971666,-0.0045999214,-0.0033688787,0.05230605,-0.047066398,0.007997262,0.055851992,-0.07879532,-0.071063794,0.10251665,-0.10219418,0.004350394,-0.021422287,-0.01426867,0.0077658044,-0.029111845,0.03900474,0.0036745023,0.02663315,0.034965005,0.02542058,0.025637938,-0.0028666253,-0.026846755,-0.033396747,-0.017451596,-0.051842075,0.05109964,-0.006954509,0.030241124,-0.0036380934,-0.04904007,0.06537902,-0.045909405,0.04317547,0.002509919,-0.02568854,-0.02005331,0.07232918,-0.022090834,0.051300153,-0.07841086,-0.13453919,0.010303665,-0.047470465,0.032304812,0.0023155806,-0.003638568,0.010502499,0.05223847,-0.08078295,0.030293837,-0.050479483,0.011028965,-0.08817555,-0.106389694,0.10948986,0.068415165,-0.066194475,-0.043945998,0.06919129,0.0029159484,-0.032805763,-0.026270764,-0.021027377,-0.03959045,-0.029780665,0.06482592,-0.0355743,-0.036590654,0.007877373,0.016640116,-0.016637305,-0.06348425,-0.010579087,-0.06979662,0.037028156,-0.0065053315,-0.0038733622,-0.010116853,-0.050312314,-0.016296733,-0.034977887,1.2235391e-33,0.027782189,-0.12178669,-0.003766464,0.11649733,0.031822722,0.048070095,-0.043377865,-0.02099003,-0.03525631,0.021343488,0.058775157,-0.11099603,0.052098278,-0.030202165,0.06552339,0.014627623,-0.0053602546,0.01410744,0.029713275,0.03899532,-0.07296797,0.012091228,0.031084169,0.024001133,-0.041601136,0.0737585,-0.009273048,0.01718893,0.05707393,0.06292726,-0.085001856,-0.06328216,-0.0814338,-0.042553313,0.012319484,0.05122715,0.022114526,-0.01792554,-0.02095089,-0.032124706,-0.020016061,0.0061186324,0.10051414,0.13234952,0.011813894,-0.008130997,0.021801295,0.05130053,-0.080348976,-0.008884198,-0.02482755,0.006570328,-0.075228915,-0.03041197,0.017948722,0.028166948,-0.05872047,-0.030250078,0.050235216,0.021094427,-0.018081866,-0.123953275,-0.0138024725,0.036680486,0.03652798,0.075157695,-0.12636751,0.10338669,0.0023875195,0.023406105,0.06702292,0.080049895,0.018154705,-0.020549405,-0.016202917,-0.02119916,-0.04330188,-0.034804963,0.005824332,0.060656436,-0.03519915,-0.029577514,-0.05876158,0.00075417815,-0.0047059124,-0.08994541,0.01748756,0.09697844,-0.0021807721,0.025026074,0.008899748,-0.0081422385,-0.09889167,0.06802499,0.055553872,-1.733597e-08,0.0083883125,-0.020040153,-0.044047635,-0.03714469,0.008611885,-0.022377169,0.051151093,-0.0022147812,0.018081786,0.03906468,0.035896067,0.062342823,-0.021365097,0.028811717,0.08284188,0.013698939,-0.017879305,-0.029025866,-0.05389359,0.030663056,-0.010078054,0.017528161,-0.039652396,-0.0541043,-0.037426945,-0.043883298,0.019037671,0.024973886,-0.10446807,0.02833501,-0.0136938635,0.06302615,-0.07854951,-0.01834133,-0.05104347,0.03964083,-0.0016315151,0.0511511,-0.0093519585,-0.03274695,0.03316142,0.015535092,-0.08595286,0.021884758,0.025252886,-0.08905928,0.020056622,-0.011018611,-0.018014494,0.026774684,0.039813153,0.045906793,0.05776422,0.005865417,-0.0029928607,-0.04962361,0.04510045,-0.046412192,-0.09900936,0.015613946,0.03925925,0.012641228,0.17670678,0.06315429 +1.4.99.4,"Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine (cf. EC 1.4.99.3 amine dehydrogenase).",384,1.0,-0.041421477,-0.047297213,-0.059985664,-0.08203673,0.05484204,-0.0026456327,-0.0025362927,0.0038180135,0.011907574,0.0600496,-0.00034973488,0.023738742,-0.04562464,0.05566488,0.021333808,0.051870957,-0.044532854,-0.028084012,-0.011697177,0.042782456,0.016544761,0.07758144,-0.0011494214,-0.041553535,-0.07164257,0.06451552,0.013411838,0.031258356,0.045742333,-0.06749481,0.021785492,0.0102482885,0.0044495426,0.022268191,-0.08239674,0.064394325,-0.047859833,-0.0049012094,0.008441227,0.024749126,0.04075464,0.036384515,-0.026560124,-0.06979894,-0.038402386,-0.08948364,-0.0070211375,0.033832517,-0.024151538,-0.05999786,-0.028715312,0.03418709,0.03870993,0.08860616,-0.053116057,0.010614483,-0.107670866,-0.0031336173,-0.048186883,-0.023224562,-0.09513348,0.004543101,-0.04867636,-0.05360336,0.019814577,-0.03856817,0.027013635,-0.055258974,0.07956479,-0.053939488,-0.035095382,-0.051924124,0.028245049,-0.011242234,0.034660514,0.008116445,0.013502152,-0.004458104,0.015562474,-0.054337304,-0.07224975,-0.09057261,-0.017014306,-0.043231152,0.099477164,0.009005873,-0.10710281,0.03828407,0.099416375,0.022850525,-0.01481193,-0.0140022505,-0.004198353,-0.023694651,-0.038311593,-0.032545604,0.065993324,0.0756043,-0.011418178,0.02392023,-0.0051471544,0.07009551,-0.18415448,-0.05216632,-0.073018745,-0.07545614,0.1382444,0.042849507,-0.09385445,-0.011612446,-0.056530036,-0.055914056,0.09958193,0.04222031,-0.038736098,0.029558329,0.058159765,-0.13442038,-0.04834347,-0.12737653,-0.032697555,0.003732263,0.031415977,-0.030815266,0.029063083,0.049092792,-0.034129974,1.2207218e-33,0.007958389,0.04989281,0.01576806,-0.038193226,-0.06395262,0.057663478,-0.050053347,0.10907635,0.04009425,-0.11862344,-0.031824023,0.010725711,0.03274054,0.053757485,-0.00536081,-0.01991091,0.072944865,0.029255293,0.08381303,-0.089896806,0.029794963,0.042296562,-0.06990223,0.010484841,-0.03145937,0.005088043,-0.017308515,0.054954886,0.0069759684,-0.01340077,0.091680974,-0.033718716,-0.028451314,0.05392092,-0.013447696,0.10141246,-0.11580028,0.07213428,-0.026207568,-0.04498363,-0.047587134,0.0049705165,-0.020534154,0.08204443,-0.050211076,0.010802374,-0.056757666,0.0049227295,-0.0063804514,0.029814186,0.015303949,0.003272029,0.053363435,-0.006598653,-0.05838399,0.06922428,0.024965795,-0.06303016,0.019955343,0.02015274,0.012835546,0.04137695,-0.08130727,0.02506063,-0.024609389,-0.024746353,0.008239963,-0.016367642,0.03910575,0.076005965,-0.022483772,-0.012954516,0.017147593,0.091312505,0.053104263,-0.009236952,-0.0014299473,-0.03538992,0.037593167,0.011050059,0.029016795,-0.056512766,-0.011509388,0.10637104,-0.076595515,-0.018239308,0.024488645,-0.039189037,0.028197741,0.01230065,0.059260543,-0.12668048,-0.0056497627,-0.014944603,0.055906717,-3.479118e-33,0.06629251,0.012908862,0.025219768,0.002299323,0.04012862,0.07502972,0.047334142,-0.06408079,0.024401857,-0.06406951,0.10161534,0.005461642,0.033267897,0.012857503,0.045473665,0.024310552,0.029210491,-0.008689407,0.010203519,0.01195833,-0.01808457,0.058718875,-0.011330851,0.030031072,-0.010022961,0.001087323,0.056319926,0.019225148,0.014090678,0.0026954757,-0.022817474,0.02705217,-0.01867946,-0.0934175,0.0045655956,0.07157122,-0.0624433,-0.0063005034,-0.09315525,-0.016810477,0.046435285,-0.006807864,0.0014706755,0.09474332,0.053670697,0.0054133553,-0.019449014,-0.04796615,-0.086362444,0.015680438,0.018505733,0.09828309,0.019457899,-0.056191992,0.16052708,0.041285206,-0.023955343,-0.10423085,0.015781164,-0.037292928,-0.0004174981,-0.027186554,-0.053645812,-0.04379477,-0.015132427,-0.06804275,0.020398889,0.04105472,0.06693215,0.0052078795,0.05815122,-0.046787556,0.07602541,0.043073356,-0.06314315,-0.06480996,-0.02955643,-0.007186728,-0.017493859,-0.033953577,0.009126669,-0.032910045,0.09050936,-0.0788056,-0.014041952,-0.021177122,-0.007352712,-0.039355513,-0.025580173,0.04551547,0.041704375,-0.0015885337,0.039752617,0.047513723,0.022248913,-3.6344648e-08,0.03681672,-0.056148324,0.082347736,-0.015037128,-0.040174183,0.016061218,0.044157553,-0.021636482,-0.016372375,0.019336954,0.03461939,0.047968864,0.056982603,-0.015872113,0.036496643,0.016463667,-0.059427686,0.0044413162,-0.06318441,-0.01462794,-0.11585827,0.024076138,-0.110826276,-0.012655188,0.044677682,0.012299828,-0.07457766,-0.061853737,0.0054094954,-0.018154027,0.049145397,0.060795467,0.08461899,-0.013588291,-0.003925465,-0.0055801147,0.06940532,-0.03989698,-0.076488994,0.0008165896,0.07009372,0.02310517,-0.06317779,0.03946853,0.03322389,0.050546795,-0.0055515403,-0.02384583,-0.007467051,-0.03830983,0.059614956,0.03490604,0.081768386,-0.02777927,-0.08077678,-0.035374578,-0.0843488,-0.059075296,-0.020172842,-0.03920896,0.07326138,-0.0075958027,0.068134315,0.054467093 +1.4.99.5,"The enzyme from Pseudomonas sp. contains FAD. The enzyme is membrane-bound, and the 2-electron acceptor is a component of the respiratory chain. The enzyme can act with various artificial electron acceptors, including phenazine methosulfate.",384,1.0,-0.08002219,-0.042732153,-0.053531136,-0.042105407,0.05929771,0.005203174,-0.07676368,0.07382828,-0.017761875,0.009216108,0.023970746,-0.05178044,-0.06527052,0.08654676,-0.00085559796,-0.0049745706,-0.08449471,-0.03296836,0.016862337,0.044748418,0.06451744,0.10437799,-0.009004858,-0.07877869,0.01583301,0.04095513,0.060079664,-0.059303798,0.018584784,-0.01619908,-0.008401952,-0.024244323,0.01921399,-0.031619843,0.0089194,0.044245556,0.024821267,0.015318884,0.052454244,0.00993658,0.027691836,0.0327453,0.0018764145,-0.09361726,0.0069185114,0.012820718,0.019576145,0.018269923,0.022990664,-0.0609016,-0.040596824,-0.0319489,0.011344093,0.11558406,-0.062581815,0.05188768,0.020256989,-0.063272476,-0.04267229,-0.036800575,-0.033788588,-0.036664736,-0.022295278,0.008079351,0.05248471,-0.046298746,-0.018133698,-0.04374385,0.019668888,-0.051336277,-0.046008073,-0.045272183,0.06347721,-0.0038945596,0.03989815,-0.024265736,-0.008039635,-0.08983483,0.07121369,-0.029125394,0.010220041,-0.0913659,0.033238415,0.08497042,0.05291965,-0.019586,0.019499615,0.0025840164,-0.042807788,0.0003623183,0.0011823791,-0.054275095,-0.018979091,-0.040831536,-0.07233045,0.07292901,0.03793493,0.07871997,-0.002160097,-0.03905649,0.0047742995,0.044368174,0.008604919,-0.08457707,-0.035831954,-0.05233302,0.028335068,0.07962417,0.00953902,-0.008383166,0.010055715,0.0036278188,0.036051955,-0.052088805,0.002660961,0.038281906,0.039415862,-0.092628926,-0.030064972,-0.05308986,-0.031013152,-0.05402413,0.050697424,0.060453165,0.08878316,-0.00479615,-0.122370645,-7.589727e-34,0.02484977,-0.00039618392,-0.024902117,-0.09688141,-0.044222344,-0.0030570042,-0.07929961,0.02326995,0.016109064,-0.058730587,-0.02398485,-0.050065625,-0.0052011474,0.015027421,-0.006580684,-0.0120015675,-0.028290704,-0.041672934,0.122965425,-0.08094524,0.06468203,0.05147466,-0.008663098,0.029638527,0.07569613,-0.053478144,0.0038550114,0.07830947,-0.02721768,-0.0014518916,0.092536524,-0.030482981,-0.08641946,0.04871389,0.017989127,0.07995356,-0.09514628,-0.0009766881,-0.065619364,0.0018917968,0.018037243,0.036049288,0.014184175,0.043139074,0.046276398,-0.06348173,-0.091377504,0.072082125,0.043702573,0.10280591,0.03132514,-0.026740814,0.043827657,0.008644482,-0.051500257,-6.6420296e-05,-0.025797797,-0.012293341,0.040282696,0.03540368,0.050803408,0.067536116,-0.04945855,0.12640487,-0.05129017,0.031077493,0.012420366,-0.05189388,0.03091437,0.11187879,-0.072582036,-0.011694059,0.03504632,0.045272365,0.03391347,-0.06622853,0.012157006,-0.04422326,0.025604997,-0.011477918,0.043123327,-0.10449714,-0.003534275,0.039488543,-0.09450655,-0.06563005,-0.015340621,-0.035469394,0.00085789367,-0.0532994,0.09106406,-0.10947042,-0.05945125,0.091533594,0.032110687,-4.6256277e-34,0.06619738,-0.049183518,0.12939058,-0.06343668,-0.018191468,0.11324937,0.01822414,-0.022104371,0.058315773,-0.04119335,0.077628024,0.045569494,0.02786117,0.0067255525,0.049031433,0.06443106,-0.018603906,-0.06248122,0.07274053,0.019551096,0.0013145577,0.05890046,0.00842352,0.06857995,0.057849925,0.04258985,-0.0380857,0.014670106,0.05564093,0.011963005,-0.007122765,0.04233101,-0.03961924,-0.014549897,-0.059367504,-0.044569436,-0.028450754,0.03187482,0.008586077,-0.012251922,0.028731428,0.001497503,0.010949449,0.09862608,0.016593987,0.03694642,-0.03704084,-0.055880617,-0.013346769,-0.073330075,-0.009266098,0.030811848,0.017710207,-0.020825617,0.0943322,0.07053866,-0.014676021,0.008066388,0.010948902,-0.055989947,-0.006000477,-0.08467035,-0.011009214,-0.050454598,0.016513214,-0.02289177,0.0064553404,0.027940787,-0.0108910175,0.024310788,0.056317035,0.036427263,-0.015720543,0.034527488,-0.07901514,0.016206836,-0.029268974,-0.006072156,0.035394423,0.040245824,0.05725388,0.064800724,-0.0173694,-0.018460253,-0.011457646,-0.034186244,0.020484047,0.056289833,-0.029013334,-0.009864892,0.0014470454,0.060041882,0.05181248,-0.020742167,0.05985803,-3.300163e-08,0.030299243,-0.066759564,0.060381144,-0.05020092,0.01787764,0.03517136,0.013180236,-0.010290223,-0.021216035,0.026348267,-0.059994556,0.12495953,-0.039920177,-0.028001338,0.07176717,0.009053332,-0.120352425,-0.010139103,-0.06783732,-0.026319671,-0.06139363,-0.009655941,-0.1370574,0.032508615,-0.015162126,0.01334059,0.033919618,-0.062694974,-0.029484225,0.020616377,-0.05435072,-0.020057684,0.03711095,-0.039134942,-0.08201786,0.02800183,0.053271607,-0.093987174,-0.11528504,0.021616613,0.09885594,-0.037946563,-0.0344734,-0.01458707,0.018695652,0.016213065,-0.001206364,-0.050958432,-0.013361195,-0.02704815,0.10802247,-0.05893475,0.030289544,-0.033989236,-0.13348077,0.045333713,-0.089912996,-0.08259797,-0.040479936,0.02227041,0.052596726,0.047074106,0.10541272,0.05522088 +1.5.1.1,"The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.",384,0.99999994,-0.059764825,-0.04939029,-0.12408739,-0.0163354,-0.0011704381,0.0870855,-0.031965356,0.09434989,0.059195165,0.021139704,-0.023235008,-0.037270866,-0.038995795,0.03931919,-0.04253386,-0.0042425315,-0.089992955,-0.054577783,0.009449436,-0.04287524,0.047674723,0.03937435,0.015051055,0.011811278,0.054505263,-0.006118259,0.030788586,0.020794667,-0.079473116,-0.051929537,-0.030688269,-0.058348212,0.044144616,-0.043883894,0.08136725,0.054874532,-0.036032386,-0.04418173,0.00045189683,0.03099554,0.031798195,0.020642634,-0.067044236,-0.009342586,-0.06939954,-0.0017623006,0.009728482,0.082619056,0.040033225,-0.013766556,-0.06283607,-0.014319206,-0.037575256,0.08030327,-0.002793702,0.064800285,0.039121248,0.0006865029,-0.072647735,-0.037660412,-0.018663041,-0.027180998,0.037424058,-0.008064307,0.01221942,-0.026325142,0.014062866,-0.0569727,-0.019279506,-0.07535044,-0.12468641,-0.071623065,0.050153382,0.03172215,-0.031169465,-0.011994427,-0.034548283,-0.03075584,0.0061802748,-0.026827212,0.01859121,-0.0123256715,-0.033899795,0.031374276,0.0072289878,0.0061519346,0.019441178,0.00040504916,0.033688407,0.015899751,0.03294309,-0.042871613,0.01716913,0.040448174,-0.13037051,-0.018449701,0.022738643,-0.00751727,0.020899203,-0.06364611,0.026752537,0.08539652,0.008093248,-0.07917866,-0.044593617,0.042158708,-0.00094725395,0.15666096,-0.034066886,0.008820572,0.03163678,-0.040138695,0.0032256863,0.011322101,-0.032739867,0.09545966,0.007024669,-0.057657287,-0.13513684,0.004577483,0.016264979,-0.059067395,0.044380207,0.032244295,0.0035993084,0.04692208,-0.088067815,5.036001e-34,0.073653705,0.023350501,-0.019433849,0.00029789263,0.041026987,0.048621338,-0.123279035,0.06577179,0.011828501,-0.07410866,-0.030691653,-0.0471051,0.03145354,-0.005526558,0.012272216,0.03615165,-0.09135062,-0.020124268,0.006344999,0.048326604,0.03985246,0.027577639,0.011045452,0.03862824,0.024656862,0.07309597,0.0049945493,-0.0014931203,-0.01967383,-0.0106868,0.06350249,-0.17881063,-0.090426505,0.011634704,0.049846534,-0.012664744,-0.025943983,-0.05389983,-0.04216066,0.113813825,-0.03639964,-0.0012990094,0.04779102,-0.037267346,0.060082644,-0.12374658,-0.03836555,0.12192189,0.060937107,0.056852132,-0.011468674,-0.027018009,0.14042978,-0.06027855,0.019095354,0.036026765,-0.076467395,0.036818195,0.041606873,0.051066905,0.053494208,0.04202544,-0.020353593,0.06459393,-0.025681643,0.061452635,-0.118271366,-0.0533871,0.035059188,0.11435182,-0.05453133,0.03992848,0.09723964,0.04225306,0.013309776,-0.040556047,-0.04163866,-0.029791357,0.012882556,0.016569525,-0.032775704,0.02389408,0.00041775455,0.038931623,-0.028812539,0.015729638,0.02701524,-0.029488442,-0.022513183,0.073718116,0.05500423,-0.015023224,-0.055737317,-0.010041863,0.01899805,-1.7961941e-33,0.08857555,-0.040090445,0.062400777,-0.113037735,0.023923283,0.0991144,0.027555304,0.019766703,0.051022604,-0.038066924,0.03470956,0.08114268,0.013204306,-0.034782346,0.054686617,-0.062149074,0.02366345,0.014971164,0.0391514,0.0017874183,0.015265889,0.05173852,-0.013543025,-0.00984498,0.00051512365,-0.07021063,0.00086358405,0.058876697,0.012824837,0.0024195048,0.06509,0.033635903,-0.024159232,-0.060751382,-0.052498057,0.089952946,-0.07932971,0.021484027,-0.017839115,0.035187747,0.019985383,-0.03525912,-0.03263297,-0.06718545,-0.0033424068,0.024470875,-0.12727514,0.015092401,0.018421724,-0.040745325,0.02556976,-0.00915472,-0.021111531,-0.006469314,0.037949353,0.007814566,-0.08546056,0.053303108,0.011171536,0.025332542,-0.018332768,-0.059908845,0.04516839,-0.005444829,0.028765542,-0.036709603,0.055102397,-0.017298052,0.08070561,0.026795425,0.1295493,0.011760301,-0.02584439,0.08371889,-0.05281605,-0.04681906,-0.06941675,-0.00810534,0.0023518472,-0.04885128,0.06305512,-0.056418482,0.02183744,-0.08201509,-0.004754354,0.029382352,-0.005596528,0.051111143,-0.015553368,0.008766803,-0.01426397,-0.027036518,-0.08717671,-0.0022769286,0.003504794,-3.9877825e-08,0.07883689,-0.02873118,0.063571185,0.0067688683,-0.0006519241,0.017331678,0.048519548,-0.022159405,0.02336758,-0.021498973,0.026325049,0.08188639,0.04540409,0.005629034,0.046023972,0.043544047,-0.046950694,0.03684991,-0.027485712,0.039766684,-0.069668025,-0.016765907,-0.13244781,0.025603462,-0.00012369337,-0.039480515,0.039709233,0.0039483355,-0.0019593758,-0.060050093,0.0153106935,-0.0143559305,0.12094484,-0.037591986,-0.04948721,-0.035799433,-0.07575282,0.05236939,-0.08624122,0.059753366,0.057469595,-0.059074063,-0.036253795,0.0023153299,-0.007773337,0.0022218847,-0.013221035,-0.036243908,-0.028656866,-0.0016610809,0.022534335,0.01030127,-0.011289911,-0.055177312,-0.089530595,0.061337616,0.019436352,-0.08776353,-0.039321225,-0.012600398,0.07234512,0.028256707,0.12991942,-0.049779113 +1.5.1.2,Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.,384,0.99999994,-0.027846295,-0.025504813,0.07179939,-0.011268585,0.0780157,0.06840516,-0.03388501,0.039623305,0.0029904775,-0.056750853,-0.020256177,0.06776639,-0.05336476,-0.02140367,-0.0145075405,0.070746586,-0.05314392,0.051550414,-0.019683195,-0.02965873,-0.0067866202,-0.083994895,0.015855042,0.09625463,0.024750043,-0.0027701613,0.039252155,0.0791676,-0.04600224,-0.07370024,0.019810997,0.034925308,-0.03186367,-0.076540895,-0.0015625817,0.028967422,-0.09113332,0.0015472113,-0.031170327,0.036585074,0.05256012,-0.054662358,-0.015717665,-0.021414768,-0.03304819,0.021316439,-0.011051243,0.010085571,0.024176834,-0.017856658,-0.03940812,0.021671314,-0.0637647,0.0028694277,-0.05959212,0.011248182,-0.027222207,0.08262381,-0.03704633,0.031478543,-0.035370104,0.01836845,-0.022019027,-0.048377782,0.014932354,0.0062159463,-0.00052416325,-0.01839785,0.060137603,0.07477153,-0.06456131,-0.047167588,0.0898442,0.029308125,-0.0036192832,-0.023325097,-0.047884293,-0.051314097,0.09146121,0.024316529,-0.0050123134,0.036099084,-0.041713692,0.081586614,-0.01151825,-0.023727503,-0.038043767,-0.04438144,-0.029089814,-0.020478714,0.066204384,0.015695794,-0.02072756,0.105761774,-0.105040826,0.013177564,-0.009226131,0.00038106376,-0.070523836,-0.04904345,0.0093857795,0.029411454,-0.059227403,-0.091821,-0.05275718,0.0010811187,0.08730614,-0.0028448747,-0.0047740396,-0.025389507,-0.03472611,-0.02961667,-0.028602859,0.052910235,-0.10157671,0.094533294,0.063211925,-0.01078844,-0.043976508,-0.036551606,0.040681478,-0.004495871,0.061748255,0.047546595,-0.07991573,-0.02641978,0.01449469,2.2963278e-33,-0.021754863,0.040104598,0.011526554,0.08534226,0.04739471,0.018639628,-0.121149704,-0.030714596,-0.02036477,-0.0330828,-0.023360288,-0.062322047,0.0050358125,0.031294815,-0.07178573,-0.09703114,-0.12957853,0.030065907,0.0125371795,-0.052026197,0.001533507,0.075269684,-0.02647789,0.065474436,-0.016695434,-0.012033165,0.06858029,0.0017627832,0.04247761,-0.0116470475,0.014792419,-0.06616,-0.06816533,0.0076032905,-0.047323123,0.07710438,-0.04473762,-0.10694651,0.02274707,0.10887675,0.016666234,0.020699263,0.029820397,-0.025100159,0.031154692,-0.07580693,-0.03125585,0.10381533,-0.056782737,0.0103469165,0.09591227,0.0023188258,0.022879163,-0.03820888,-0.043370254,0.02149602,-0.069975905,-0.025212638,0.0010313415,0.032391597,0.033275377,0.005485406,0.0014932149,-0.02860722,0.027287502,0.03572318,-0.00058367447,-0.03816572,-0.025879608,0.00018286819,-0.05848369,0.009952084,0.13083304,0.088229336,0.03361756,-0.0021904043,-0.030443672,0.013587974,0.020794338,-0.016182225,-0.01507248,-0.007617941,0.04631139,0.045995817,0.0060768854,-0.04842561,0.033547465,-0.040962365,0.065813966,0.008447342,-0.010624797,-0.14020126,-0.008829727,0.071815945,-0.05720825,-2.6245283e-33,-0.0045025423,-0.09072921,0.080535516,0.01959995,-0.0020195295,0.000164617,0.09406836,-0.07166903,0.072465286,0.03690152,0.087196164,0.0031167248,-0.032584965,-0.03862079,0.02950738,0.0010659733,0.01354566,-0.008273358,-0.0436753,0.0165178,0.038485844,-0.0015589085,0.021649092,0.1293692,-0.0074999086,0.009653586,0.0331209,-0.02489636,0.11461235,0.064475484,0.048287626,-0.02408983,-0.058286786,-0.13132133,-0.05486722,0.096231125,-0.05132782,0.041849863,-0.03736552,-0.013538254,-0.0054740184,-0.058040246,0.018489258,-0.08741908,-0.012371977,0.02627763,-0.046600267,0.014064097,0.0036274618,0.052258123,0.0028441984,0.018303672,-0.026906323,0.014842476,0.03840443,0.016851941,0.01180974,-0.056529548,0.002670093,0.026409585,-0.032687522,0.03471707,-0.015651159,-0.05214326,0.027948163,0.030905284,0.015628563,0.040610246,0.11886871,-0.03529068,0.15675546,0.07481384,0.054663777,0.05708353,-0.03334196,-0.011731626,0.04394063,-0.03758741,-0.0073177963,-0.021355951,0.048961423,-0.073339604,0.014842345,-0.11205429,-0.028276227,-0.0042174347,-0.026923016,0.1472854,0.043280516,0.04711309,0.024775712,-0.05951496,-0.031070527,0.025623705,0.009138385,-2.7071573e-08,0.02225439,-0.03298502,0.06654328,-0.04568143,-0.08561431,0.011873959,0.041764725,0.05281175,0.020661931,-0.08380114,0.018496571,0.054489058,0.0044891303,0.028540572,0.004260907,-0.004902162,-0.017992642,0.078806944,-0.025337793,-0.03468756,-0.10414318,-0.015022023,-0.06712661,-0.017869854,0.021527389,-0.0381072,0.0779596,0.083632,0.02637182,-0.030763881,0.038825292,0.011282089,0.057487193,-0.01528533,0.015171282,0.04565889,-0.01784416,0.04912756,-0.043522943,0.09731722,-0.041177824,-0.037158675,0.013352789,-0.008823869,0.039686408,-0.082682565,-0.053192884,0.040479463,-0.015877657,0.059464328,0.07014987,0.027360305,-0.04358171,-0.060553852,-0.10806829,0.017222121,-0.020901233,-0.03673362,0.0142913,-0.13017692,-0.074560925,-0.012434019,0.1361783,0.03672354 +1.5.1.3,"The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.",384,0.99999994,0.056779295,-0.0007240547,-0.03868619,0.030593345,0.10141218,0.01545843,-0.09349698,0.06984314,0.048109982,0.022090998,0.015349482,-0.008406563,-0.09439493,0.029247193,-0.036513068,-0.02629154,-0.08650357,0.029966319,-0.081543304,-0.025598917,-0.019240858,0.014159366,-0.04776318,0.06598998,-0.012443631,-0.09160381,0.008313744,-0.041107133,-0.08013444,-0.018872097,-0.049874984,0.04597559,0.072172135,-0.00032331483,-0.01652951,0.13004589,-0.010222389,-0.022405464,0.029100494,0.033171237,-0.048247617,-0.09404896,-0.028572727,-0.06343071,-0.04924187,-0.021821167,0.017785054,-0.0057700546,0.047454838,0.057022247,-0.12656207,-0.01720336,-0.07379714,0.016980233,-0.014460739,-0.04440336,0.027885973,0.0067796013,-0.04753489,0.1087956,-0.0016209532,-0.044649106,-0.025707014,0.03555314,0.041632652,0.044868186,0.06245508,-0.15828267,-0.062352456,0.024569899,0.024083693,0.0017669045,0.09342761,-0.02624661,-0.0028138543,0.026784869,-0.06343486,-0.040944025,0.042479016,0.013747666,0.04068811,0.043622743,-0.024421345,0.021169804,0.059083622,-0.09085901,-0.03875714,0.0011263724,-0.039325755,0.023463897,0.04584541,0.050467446,-0.055655815,0.012420141,-0.098256506,-0.0039456007,0.04753892,-0.06816268,-6.8898815e-05,-0.040183805,-0.045159813,0.038870256,-0.06657511,0.008483284,-0.006254036,0.025073223,0.013952394,0.059028856,-0.08807284,0.027740728,-0.011845917,0.044043195,3.391688e-05,0.049602643,-0.047109906,0.06637721,-0.011928858,-0.071495995,-0.024141667,0.06873794,0.006476779,0.036178958,0.0620388,0.06546501,-0.02411873,0.027098017,-0.017424606,-2.7887915e-34,0.040193297,0.057558853,-0.016162934,0.026466714,0.046722785,0.0017487755,-0.048557285,0.060953595,0.05640832,-0.036630698,-0.0042286986,-0.035014622,0.046115723,-0.028036831,0.031410262,-0.05753325,0.020635983,-0.039309166,0.08181791,0.037439074,0.017487623,-0.004578206,0.0038605283,0.012327631,0.0024328246,0.08110843,-0.03854041,0.08553903,0.0012230045,0.009580341,-0.03325407,-0.09506655,-0.102735095,-0.05909378,0.13287613,-0.023226932,-0.017505331,0.007119635,-0.02718778,0.08444359,0.070182994,0.023572978,0.015030733,-0.038830772,0.0720116,-0.026917918,-0.044803463,0.047177874,-0.01647918,0.031258173,0.08353494,-0.018066416,-0.0012200957,-0.007135382,-0.04263649,-0.072369345,-0.04776589,-0.024172435,-0.07948658,0.06863388,0.013759758,-0.025536552,0.025588578,0.026378196,-0.028240297,-0.036193307,-0.049645986,-0.059123535,-0.07217534,0.035496708,0.026154907,0.042168528,0.13353983,-0.016576689,0.0095014,-0.022147205,0.022825487,-0.003468755,0.043767795,-0.042832877,0.071043104,0.020123819,-0.016686238,-0.0065455534,-0.08832123,-0.0009865849,-0.0032636323,-0.019980459,0.028160546,-0.08096254,0.044980798,-0.13820659,-0.04767383,-0.05396204,0.049469095,-4.3923173e-34,0.05808152,-0.08926333,0.052765917,-0.034257475,-0.044849496,0.0737723,0.07132209,-0.015650094,0.02352075,0.00081384473,0.0724477,-0.007926824,0.054808684,-0.0898144,-0.06478887,0.07146509,-0.0052051772,0.026909526,0.05070332,-0.07502806,-0.0710256,0.037778772,-0.011680006,0.026642669,0.07381638,0.064216085,-0.07390863,0.056433596,0.07649044,0.021914259,-0.0062730843,-0.0075987037,-0.02549796,-0.031132713,0.0051661944,0.084363125,-0.08389335,0.0037939372,0.020698117,0.058728985,0.016823402,0.0029039667,0.066953436,-0.058063332,-0.013275671,0.08552834,-0.021425556,-0.0332198,0.010248182,0.036710914,0.09716149,0.016997112,-0.12480662,0.005845235,-0.0060937204,0.02375216,0.029455837,-0.011964453,-0.033252303,-0.033919003,-0.013242815,-0.0030485257,0.035254586,0.0056156227,-0.01718045,0.025307896,0.010068235,0.08193216,0.09215113,0.06734922,0.07638553,0.020913802,0.04183548,0.033106655,0.0073793232,0.011534022,-0.0072777653,0.0034421263,-0.010395971,0.05809553,0.023111999,-0.032705907,-0.0073250923,-0.011313459,-0.041459974,-0.08171505,0.006639419,0.013710051,-0.0107533755,0.048597604,-0.0056810337,-0.05217291,-0.0023637724,-0.013655377,0.10061116,-2.4529019e-08,0.0837282,-0.11252853,-0.060310654,-0.03733258,0.06908334,-0.05302631,-0.005727743,0.038824826,0.027369462,-0.034750175,-0.09221395,0.070494756,0.011235786,0.08912673,-0.017833421,-0.023920037,0.010992394,-0.037263643,0.013596607,-0.010804666,-0.124455094,0.022192543,-0.10478785,-0.043374207,-0.009645608,-0.047007143,-0.027333776,0.015219811,-0.02474141,-0.015439364,0.01980031,0.03695033,-0.023413923,-0.025978351,-0.054785818,0.08519016,0.015190222,-0.008761769,-0.08140657,0.104614265,-0.026059754,-0.015054529,-0.13679779,0.005225722,0.010338062,-0.052289836,-0.020539194,0.051250607,0.0067906273,0.040050514,0.023532853,0.075893566,-0.047056384,-0.0068316,-0.04406274,-0.024581064,0.0030918766,-0.039335143,-0.03906251,-0.051764492,0.0013912047,0.013346416,0.15106635,-0.06738583 +1.5.1.5,"In eukaryotes, occurs as a trifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and formate---tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes occurs as a bifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase activity (EC 3.5.4.9).",384,1.0,-0.029682275,-0.088127084,-0.09956285,-0.05064753,-0.004450344,0.005461658,-0.079766236,0.068587184,0.054132666,0.009664824,0.08383031,-0.0910441,-0.03176757,0.07297221,-0.0063562035,-0.015461183,-0.13039201,0.004556817,0.018098088,-0.07045825,0.0639495,0.047916684,-0.008981904,0.008513788,-0.0018329014,-0.07710565,0.03997746,0.012022698,0.020091245,-0.022244276,-0.03155043,-0.0038025146,0.015185256,-0.0028773441,0.082897715,0.09096748,-0.05761411,-0.08399882,0.0101588,-0.013763194,0.06582563,-0.022043135,-0.013018703,-0.014444105,-0.018430443,0.07976346,0.057272147,0.011407125,-0.0035224967,-0.0316931,-0.049078036,-0.06284933,-0.031561196,0.01224542,0.004266212,0.0038234957,0.019218542,0.011844954,0.034041725,0.024959704,-0.014875656,0.018002002,-0.020938637,0.009200597,0.015140392,-0.053165693,0.103562005,-0.075618505,-0.04637546,-0.016344681,-0.035284813,-0.05783646,-0.052703947,0.059856288,-0.061583105,0.05015202,-0.025007019,-0.085195206,-0.045042865,-0.01792595,0.02335065,-0.0073523014,0.01777352,-0.020447591,0.01566578,-0.082182676,-0.02994628,-0.04484451,0.0072604483,0.01653724,0.013704307,0.0074342145,-0.034953613,-0.053596694,-0.083541356,0.025540821,0.11676581,0.06521306,0.10651976,-0.083083585,0.006086834,0.029998206,0.008056982,-0.018322414,-0.022711333,0.015843486,-0.010533309,0.070766024,-0.03552674,0.06290881,-0.032663584,-0.07418749,0.061002903,-0.034930594,-0.02977446,0.053270586,-0.0021112543,-0.05885381,0.023023462,0.06978336,0.01272141,-0.015104342,0.09959256,0.07035236,-0.006773338,0.081314005,-0.085140534,4.4430064e-33,0.046859447,0.010100291,-0.05534517,0.042474646,-0.012306026,-0.008672416,-0.04928858,0.03120798,-0.047263175,-0.06130738,-0.072844245,0.019644529,0.08752386,-0.016249623,-0.01579444,-0.0049534165,0.044662632,-0.021308215,-0.00064687926,0.110915,0.015201032,0.016513508,-0.0029732054,0.018767392,0.013468817,0.002861591,0.014203375,-0.019648924,0.036804825,-0.0026709803,-0.04850329,-0.179758,-0.11583393,0.04501076,0.09830802,0.029867139,0.0029520271,-0.049213484,-0.032886326,0.02534188,0.0025261906,-0.059310406,0.027373698,-0.105798766,0.07709899,-0.021045836,-0.052479792,0.07750633,-0.028373148,0.021643013,0.03521166,-0.022348624,0.09822572,-0.016610691,-0.040954597,0.06144533,-4.673454e-05,-0.039201405,0.043511856,0.08575232,-0.044841055,0.07752848,-0.06626028,0.01527626,-0.015374518,0.039357524,-0.05947229,-0.07385271,-0.012263416,0.007834739,-0.06359986,-0.007707642,0.11083369,0.033359617,0.05871373,-0.021591874,-0.069119446,-0.059288777,0.017924277,0.043470345,0.0011733036,-0.016578292,0.04392315,0.025402473,0.023425916,-0.027733857,-0.045251843,-0.011037187,-0.06953344,0.01908985,0.08760293,-0.07898175,-0.009337091,0.03974883,0.05751802,-6.4096386e-33,0.083192214,-0.011791232,0.025022285,-0.13354763,-0.02254724,0.08881285,-0.042053293,-0.050612755,0.035188757,-0.042431377,0.07696367,-0.072576955,0.015753787,-0.043212976,-0.035163008,-0.037348732,0.004996824,0.11603218,0.024207938,0.027696485,0.0072484436,-0.006500524,0.011642393,0.0014292126,0.04617523,-0.026128788,-0.0007417036,0.06733453,-0.028468182,0.057918597,-0.07160661,-0.01407519,-0.004579345,-0.030045323,-0.06211409,0.044025864,-0.054887254,-0.023199677,0.049994715,0.0044991514,0.049929675,0.08855539,0.04241369,0.05636168,0.005295382,0.056831535,-0.06836102,0.0006581432,0.0067688483,-0.02967167,0.015217024,0.006930117,-0.014923556,-0.0045131743,-0.026888074,0.08057922,0.078940034,0.074473865,0.0013668579,-0.009815098,-0.0071077226,-0.054153673,0.054900855,0.030640688,0.033908505,0.018483048,-0.065175176,0.030863384,0.041281395,0.003916472,0.044565886,0.026817027,-0.041677464,-0.03218811,-0.018978465,-0.017093861,-0.068414964,-0.031179965,0.03633957,-0.0052716434,0.061514873,-0.021326544,0.03408509,-0.023350304,-0.023848403,-0.08246579,0.0103902295,0.067790076,-0.021834781,-0.0321348,-0.014555138,-0.032507457,-0.058716185,0.06563104,0.07783393,-4.705636e-08,0.03743678,-0.0029285678,-0.0048863576,-0.10965939,0.09363302,-0.008953792,0.024465855,-0.0035906497,0.05457155,7.514081e-05,-0.018873474,0.019619733,-0.01630978,-0.01823944,0.069010295,0.08265711,-0.02971114,0.03425954,-0.005052362,0.075599596,0.0148108555,-0.042005073,-0.10815999,0.06913821,-0.047154576,-0.05052763,0.05448424,0.056473125,0.0014927752,-0.028837856,-0.09544505,0.030903464,-0.068311095,-0.026167529,-0.077392586,-0.012239035,-0.021198483,-0.019085396,-0.07214569,0.06686717,0.030300897,-0.04180452,-0.10818399,0.025107816,0.04688832,0.036792606,0.02259594,0.032963175,0.008780725,-0.044573214,-0.012823399,-0.010636458,0.02153696,-0.061396517,-0.06734894,0.0052533336,0.0008845785,-0.08155205,-0.06777344,-0.0057980693,0.0128479665,0.044846833,0.22670038,-0.058498006 +1.5.1.9,"The activities of this enzyme along with EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming), occur on a single protein.",384,0.99999994,-0.030668093,-0.06583367,-0.032569434,-0.03490343,0.091282666,0.056636818,-0.06691534,0.06525945,0.041344795,-0.0048916256,0.039200395,-0.006767464,-0.059283957,0.04616749,0.0045805983,0.046398774,-0.08049249,-0.072830774,-0.0028429064,-0.03788918,0.054462664,0.0048300438,-0.024457539,-0.023951136,0.06681359,-0.0024845928,0.04110866,0.031026531,-0.04630098,-0.05718215,0.023689609,-0.047957726,-0.01186289,-0.012494147,0.00783871,0.11190129,-0.072635785,-0.073040396,-0.006854213,0.056536898,0.030211974,-0.026128277,-0.11020491,-0.053710423,-0.010849547,-0.018192315,-0.020789629,0.0915667,0.008432178,-0.0024971266,0.027136099,-0.043173566,0.011228101,0.004645388,-0.0577269,-0.05926643,-0.0661012,0.04717527,-0.015333042,-0.04513877,-0.033501647,0.034097727,0.0422124,0.0147973625,0.07431986,-0.090206556,0.06293539,-0.03978275,-0.0066635995,-0.012838862,-0.08531397,-0.064656645,0.013808135,0.06718667,-0.036973573,0.009039587,-0.028837936,-0.05160553,0.08681046,-0.06254247,0.040723976,-0.0035057412,-0.03313113,0.05270193,0.028408581,-0.010915218,0.052893117,0.013169465,0.025413452,-0.0023630424,0.035542667,-0.088125266,-0.041691367,0.031099087,-0.07211648,0.027935542,-0.006093603,-0.0007709713,-0.0053588967,-0.06477003,-0.006969317,0.08760605,0.02782643,-0.0039189765,-0.026422927,0.0183983,-0.015916314,0.06923053,-0.05625653,-0.051693305,0.026302543,-0.02869679,0.041907873,-0.008184669,0.030134445,0.1274696,-0.013079416,-0.04973401,-0.07329779,-0.019543434,0.030459028,-0.045289338,0.09675404,0.08000309,-0.04749862,0.07579265,-0.12762064,-1.9489944e-33,0.10732481,-0.056550596,-0.03874209,-0.046331003,0.0075044697,0.0054471483,-0.09670155,0.10979467,-0.013768466,-0.024756027,-0.012839078,-0.04598549,0.12047811,-0.021331862,-0.035428107,0.013664368,0.022818679,-0.011454805,0.037195276,0.013658132,-0.0019338694,0.055909794,-0.00027956936,0.015878344,0.030112246,0.026270531,-0.046788402,0.017826991,-0.020810284,-0.007011468,0.017307844,-0.13419475,-0.1186862,0.027336612,0.085766695,0.07078629,0.023098007,-0.02139247,0.010754384,0.010122934,-0.011921332,0.031603076,0.025227748,-0.09833802,0.024238886,-0.039398268,-0.07309813,0.053141948,0.03985625,0.012285146,0.082199045,-0.046927318,0.09130911,-0.13068457,-0.043890107,0.050520472,-0.05380458,0.0015868817,0.029129028,0.07963992,0.045742296,0.030231256,-0.074006215,0.036775745,-0.008544673,0.028404793,-0.093848266,-0.06342939,0.027102048,0.03480616,-0.08138738,0.0015365672,0.12344011,-0.04570249,0.033606198,0.008169205,-0.034512777,0.050180484,-0.0099920975,0.07865476,-0.028336393,-0.06487845,-0.06484922,-0.027674362,0.008496712,0.07566266,0.04614296,-0.06052723,-0.0043785535,0.031838927,0.039942317,-0.010367676,0.027799368,-0.025213413,0.021361085,-1.1459882e-33,0.02643292,-0.037465435,0.047010537,-0.09617044,-0.00010306809,0.10608939,0.044402044,-0.054404587,-0.021877518,-0.013840475,0.064403765,-0.013456564,-0.010192786,-0.050068803,0.04210451,0.05272976,-0.099539585,0.074613035,0.004685702,0.044711985,-0.000990535,0.105095096,0.09137803,0.041106556,0.08975765,-0.036622155,-0.035237707,0.042839915,0.04966996,0.005420898,-0.044317465,0.012861956,-0.013455393,-0.04145841,-0.031936698,0.011717117,-0.06164371,-0.029675186,0.068385825,0.011825399,0.014915582,0.017817106,-0.05077619,0.09506909,0.0639912,0.014533428,-0.088257626,0.009897393,-0.03221935,-0.054882802,0.0071812207,-0.018998504,-0.03203853,-0.017066889,0.011008985,0.12026367,-0.013278605,0.1320496,-0.0019509771,0.023358822,-0.022550885,-0.0077387965,-0.009732159,0.00061226863,0.08985724,-0.0057023326,-0.04388924,-0.036156744,0.023177553,-0.034107715,0.08175906,-0.0031921403,0.028759236,-0.005467538,0.0053568315,-0.04796835,-0.114633895,-0.049994674,-0.0238434,-0.031023325,-0.030071143,0.025447069,0.008550438,-0.04998023,-0.023276983,-0.016579561,-0.0025828616,0.0949738,0.022722721,0.01352088,-0.05372765,0.019324858,-0.05807776,0.045941275,0.023710018,-2.9423886e-08,0.053174354,-0.038658857,0.033840645,-0.04381589,0.037859194,0.018246762,0.044506233,-0.026444796,0.009400593,0.034572106,0.011758144,0.12526648,-0.025044907,0.013661824,0.032586396,-0.021570409,-0.048945483,0.052494995,-0.036253527,-0.022122769,-0.0007588062,-0.034047186,-0.06938672,0.063344285,0.020052992,-0.06629854,-0.05339888,-0.007298586,0.021314675,-0.07630393,0.014164675,0.0464807,0.06202608,-0.06673928,-0.02809857,0.03422238,-0.07576294,-0.0047273804,-0.049795344,0.11247261,-0.01642993,-0.06411824,-0.010586676,0.0043650344,0.021238962,0.036878455,0.04764391,-0.051023543,-0.030843481,-0.026441308,-0.00017322363,-0.052212458,-0.00019957585,-0.039598797,-0.03609935,0.008127554,-0.053870495,-0.085611194,0.049494956,-0.06495464,-0.011523676,0.055574022,0.16092971,-0.053776797 +1.5.1.11,"In the reverse direction, acts also on L-ornithine, L-lysine and L-histidine.",384,1.0,-0.021251002,-0.09133949,-0.022173692,-0.023375977,0.06454013,0.058721576,-0.03043552,0.05133171,0.010565881,0.043921836,0.0474073,0.06807317,0.015627524,0.09045314,-0.030118931,0.0687007,-0.07357904,0.0137087535,0.004928769,0.024793373,0.03473692,0.039645415,-0.0012952504,-0.013353837,0.00053918397,0.025851715,-0.012196559,0.020963628,0.023690732,-0.09614025,-0.0033161524,-0.012429638,-0.006671642,-0.020381834,-0.054609697,0.012780717,-0.10151507,0.010385124,0.07390658,0.08320054,0.045722187,-0.070520975,-0.110606484,-0.063483946,-0.0044838106,-0.0075118435,-0.08890881,-0.009792331,0.034198374,0.12599401,0.0046166214,-0.034632742,-0.05070788,0.10031027,-0.119487286,0.008530191,-0.12460549,0.05936993,0.006903142,0.06048202,-0.0012381739,-0.0021653464,-0.012299395,0.037785478,0.05256874,9.842032e-05,0.031659164,-0.05372101,0.013808309,-0.01062049,0.061854817,-0.078149945,0.024604576,0.016524144,0.039603807,-0.05416631,0.0074445833,0.027873285,-0.042566083,-0.015969474,-0.033425853,-0.0051506143,-0.041684832,0.114589155,-0.0025819195,-0.02614672,-0.09212068,0.02350019,0.053323973,0.015647994,0.01042867,-0.07061293,-0.032999836,-0.018594883,0.021379093,-0.009307751,-0.005890638,0.023157785,-0.005625653,-0.03197644,-0.021391135,-0.013630164,-0.14382929,-0.03357019,-0.012825921,-0.033006158,0.026341734,-0.07462109,-0.059987545,-0.06809381,0.023242526,-0.017104588,0.08326704,-0.0026444145,-0.04558484,0.059777126,0.04034557,0.028832432,0.0065896143,-0.06398992,0.020740489,-0.059384346,0.015703036,0.076768994,-0.032579467,0.08378809,-0.031662963,-1.1768518e-33,0.06791105,0.015511296,0.04782907,-0.0016059615,0.01615625,0.06948032,-0.02962337,0.002366666,0.050802156,-0.08121007,-0.0020510133,-0.020635623,0.05504912,0.041108213,-0.10487886,-0.062087253,0.022206107,-0.016271455,-0.019027047,-0.06478764,0.04041976,0.115234055,-0.06935878,0.0018007023,-0.006921593,0.016380645,0.022755994,-0.023235666,-0.027518028,-0.019804958,-0.016475836,-0.044126958,-0.016604051,0.0043196445,-0.008138767,0.12291214,-0.06265816,-0.017188853,0.007721077,0.016413908,0.0236351,0.05872444,-0.10517215,-0.016561696,0.032565445,0.008743623,-0.10505206,0.047171798,-0.03181282,-0.0058435667,0.10996495,-0.07621516,-0.003219843,-0.08514543,-0.04538453,0.051753595,-0.034527604,-0.007639584,0.010520979,0.082337335,0.09641952,0.05336256,0.02031448,0.01566559,-0.008670801,-0.005554354,-0.06764583,-0.08085796,-0.04018423,-0.008465371,-0.11166553,0.012351942,0.10191805,0.029196726,0.043509904,0.02489243,-0.1246991,0.03406537,0.042543586,-0.020400925,-0.0047065546,-0.06171583,0.021994516,0.024584144,-0.012628637,-0.073798,-0.005618638,-0.15462911,0.004501844,0.006293678,0.03264056,-0.038506027,0.018386513,-0.009311541,0.010929963,-1.3760003e-33,-0.013134984,-0.09253502,0.040880036,0.046722505,-0.040844414,0.03902809,0.03809534,-0.0093983365,0.092439964,0.05913761,0.045034103,-0.044034503,-0.07280343,-0.058666356,2.7835125e-05,0.040130604,0.043320574,0.08259571,-0.010532234,0.028525114,-0.09400625,0.049879167,0.067425355,0.07291815,0.084102154,0.026183689,0.03977604,0.051021606,0.04627081,0.013952656,-0.010306095,-0.028618313,-0.031134373,-0.096993424,0.012529957,0.08134948,-0.04473954,-0.026258066,0.0031757418,-0.09795441,-0.0018662203,-0.040570777,0.08665446,0.06076491,-0.01687042,0.006443045,-0.05612862,-0.0061189937,-0.07142416,-0.08533606,-0.028177693,-0.006432026,-0.0027495495,0.018569645,0.07194335,0.045910064,-0.0029530204,-0.043932285,0.0022561846,0.01708344,0.009437303,-0.014061103,-0.022547679,-0.019886175,-0.01701643,0.052122682,-0.044054847,-0.0074902796,0.055826433,-0.069176205,0.03922633,-0.010135721,0.03923925,0.013604134,-0.073504135,-0.039290454,0.0031249323,-0.14867507,0.011171369,-0.06493966,-0.09773377,-0.035781506,-0.03199316,-0.012437425,-0.046104826,-0.008050814,-0.03891167,0.106370434,-0.0014223881,0.03722924,0.0011323681,-0.029541237,-0.02579635,0.016628128,0.1288024,-2.6966736e-08,0.040620595,-0.088508695,0.102269575,0.04334226,-0.02998543,-0.009859054,0.034081973,0.022511303,-0.0117126,-0.052678317,0.011270508,0.09353103,0.05194653,-0.058910586,0.050652415,0.032992326,0.004475639,0.068336606,-0.015088446,0.042526845,-0.05596965,-0.041150678,0.0015912396,-0.015334073,0.03354589,-0.008894975,0.022225227,0.08663711,0.07291229,-0.07692614,0.055680413,-0.030003328,-0.0031841786,-0.03464874,-0.041313335,0.024153328,0.02791087,-0.007931843,0.06494136,0.024794979,-0.028665587,0.034665525,-0.041380998,0.062501,-0.03622578,-0.035916924,0.02931388,0.0058791474,-0.0034637877,-0.04593655,0.016622411,-0.04663047,0.04746069,-0.01118424,-0.026267044,0.057833184,-0.054138497,-0.03266753,0.001177036,-0.033556223,-0.016995294,0.05157959,0.13376857,0.051353127 +1.5.1.12,"This enzyme catalyses the irreversible oxidation of glutamate-gamma-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.99.8, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity [5].",384,1.0,-0.0536473,-0.080148436,-0.024347601,-0.059004184,0.06313953,0.042908072,-0.039442305,0.048437737,0.0214409,0.03620783,-0.0034367752,0.03957469,-0.018789027,0.05729653,0.013880473,0.036410764,-0.055979725,-0.044311713,-0.008922536,-0.032601807,0.010980162,0.023705566,-0.061322547,-0.026013844,0.05713278,0.0300492,0.09728506,0.03474891,-0.09704414,-0.08392003,-0.018311316,-0.0641851,-0.016348021,0.0007725734,0.036218658,0.084026255,-0.13103253,-0.048862163,0.069143996,-0.027529337,-0.018435584,0.043004844,-0.079858914,-0.079751655,-0.03660327,-0.037715025,0.03242833,0.0219996,0.022328012,-0.050059855,0.011538643,0.06626746,-0.0017939688,0.06361996,-0.028496075,0.01597609,0.01579982,-0.03292566,-0.058183298,-0.020995902,-0.050296232,-0.04612717,0.0061078602,-0.07947402,0.00078209094,-0.027242215,0.058331262,-0.04618294,0.020048397,-0.02603242,-0.16185696,-0.046998065,0.029541407,0.0529346,-0.032040965,-0.031986866,0.008417493,-0.03110321,0.053874537,-0.049297698,0.021127759,0.011513874,0.038883884,0.036696367,0.0397693,-0.038520973,-0.0216514,0.05228677,0.07025892,0.037563063,0.0069937916,0.0365224,0.010117003,-0.01298164,-0.05551986,0.007490753,-0.03920034,-0.013416805,0.014852648,-0.07745364,-0.003660187,0.08281201,-0.0028193598,-0.07695442,-0.025265642,0.053783942,0.042567834,0.096026875,0.0058442648,-0.016277337,0.0064619454,-0.045073614,0.047979303,0.029741272,-0.03399175,0.051678974,0.0037500826,-0.029841261,-0.08270505,-0.020359611,0.02972572,-0.014386474,0.0968579,0.0013202006,-0.042051557,0.058249228,-0.05806156,4.4600357e-33,0.011632014,-0.005872833,-0.035247043,-0.0039633797,0.049739357,-0.0053684777,-0.09691828,0.084300965,-0.0062901913,-0.03382209,-0.046372008,-0.09300684,0.036570355,-0.028160896,-0.0035094724,0.005678985,-0.07104013,0.00422559,0.008247489,-0.011752338,0.0136255715,0.100980505,0.022103887,0.009858985,0.025442578,0.03217384,0.03287102,0.061412055,0.0066502313,-0.027225967,0.05314881,-0.13881464,-0.11585861,0.033418015,0.05902572,0.012844371,-0.016141575,0.0032107462,0.030485155,0.10060032,-0.036032047,0.037920143,-0.031601887,0.002410025,0.049299408,-0.079055205,-0.0106418375,0.14373001,-0.028587414,0.08374876,0.054752078,-0.026825512,0.10021527,-0.09331539,-0.05207025,0.058413923,-0.016657542,-9.984293e-05,0.081386805,0.06297528,0.03157893,0.053276695,-0.06427244,-0.020716911,0.05560698,0.04148508,-0.026815861,-0.09114321,0.024079831,0.022410894,-0.039687067,0.04735619,0.1014562,0.036721602,-0.01142563,-0.0055777193,-0.065738425,0.036733925,0.0652178,0.0023382083,-0.08346243,0.033359557,-0.0048881867,0.020787809,-0.019392708,-0.015790092,-0.0034043412,-0.08403535,0.004230103,0.047635093,0.039606366,-0.08479566,0.0033041562,0.02926816,0.03258886,-4.028136e-33,0.10048982,-0.05693403,0.039172567,-0.031610586,-0.02941863,0.105087794,0.015838208,-0.0489658,0.04770235,-0.005232116,0.031612128,0.09332471,0.053950667,0.023988677,0.05864042,-0.011333499,-0.05326473,0.084665574,-0.06771298,-0.033336755,0.09854237,0.081315376,-0.0155501105,0.041600604,0.035792563,0.019633178,0.041105784,0.024787942,0.07614772,0.0488201,0.040486082,0.03935786,-0.021138541,-0.08028645,0.0043250667,0.04822807,-0.084036306,0.030788682,-0.026133494,0.057530917,0.023112984,0.06369845,-0.013968585,-0.047122907,-0.026436035,0.044981726,-0.0851667,0.0014371516,0.012988406,-0.039065786,0.02638542,0.0180491,-0.061275966,-0.049574103,0.032604057,0.024090879,0.026859242,-0.016261693,0.0042321924,0.008980131,-0.060704943,-0.07962468,0.09556288,0.014912461,0.0073734997,-0.015045055,0.051675025,0.023515102,0.0784043,-0.03294096,0.07924888,-0.002971475,0.0336193,0.015307842,-0.008752019,0.052595235,-0.009997125,0.001918417,0.04417085,-0.01791506,0.06531082,-0.06297727,-0.029709516,-0.09518238,-0.03229475,-0.088204615,-0.016119998,0.129028,0.06110129,0.021107903,-0.019694079,-0.04010947,0.00024075077,0.05105218,0.050355766,-4.6987033e-08,0.009963714,0.010373882,0.07681944,0.012558358,0.013556674,0.037264008,0.04932062,-0.050813742,0.07927925,-0.056259483,0.012952911,0.070344955,-0.054114696,-0.027519438,-0.012310826,0.009853324,-0.043168366,0.03069904,-0.01733716,0.0037095072,-0.08162676,-0.042181633,-0.1476249,0.02028298,0.06758958,-0.07272395,-0.005675528,-0.0020232382,-0.026886055,-0.043890577,-0.039619826,0.07753464,0.058321,-0.06614753,-0.045005295,-0.06486672,0.0045576543,0.04772811,-0.055064715,0.06327398,0.019361554,-0.06678652,-0.063798025,-0.051617064,-0.032352507,0.04970858,-0.017842626,-0.006190052,-0.086822726,0.012195348,0.043646432,-0.02096829,-0.017455002,-0.0223466,-0.11575391,0.071361646,-0.013390262,-0.09125557,-0.040329404,-0.05736802,0.024839517,0.045351427,0.11284335,-0.03886098 +1.5.1.16,"In the reverse reaction, a number of L-amino acids can act instead of L-lysine, and 2-oxobutanoate and, to a lesser extent, glyoxylate can act instead of pyruvate.",384,1.0,-0.035352245,-0.10932646,-0.019398466,-0.0078122932,0.03302452,0.089840665,-0.053394597,0.038033985,0.018805504,0.083056286,0.004240165,0.02735824,-0.08121106,0.01710025,0.023251574,0.03251822,-0.028175652,-0.050073087,0.002912103,0.023645602,0.061838813,0.0014887567,-0.054381534,-0.017317284,0.049013846,-0.014970004,-0.015234359,-0.0019012148,0.009667389,-0.033543907,-0.0028604055,-0.04066939,-0.012560258,-0.044671524,-0.020679729,0.12050965,-0.1358508,-0.055226285,0.040497977,0.010462187,0.022573857,0.03857658,-0.029517166,-0.05591716,-0.041731823,0.017084174,-0.0025063846,-0.01072839,-0.029921545,0.027507635,0.032541174,0.01126895,-0.13935934,0.04131123,-0.07018008,0.03510507,-0.079597786,0.05427025,-0.045275465,-0.0064020515,-0.05147953,0.043834034,-0.0081809275,-0.021689577,0.037109092,-0.048424423,0.024848025,-0.09471685,0.01863641,-0.032599166,-0.021904338,-0.07262921,0.0614048,-0.026538946,0.035664152,-0.026847139,-0.06368013,0.042739663,-0.037372395,0.00356032,0.009749326,-0.030228373,-0.05168611,0.03658682,-0.032346208,-0.055586193,-0.05427376,0.008110268,0.04985383,-0.0008491519,0.0059153596,-0.016713338,0.060203,0.027481986,0.03345559,-0.034133375,0.096446656,-0.0076346,0.04814596,-0.04782101,-0.010773386,0.13206756,-0.057223223,-0.066056214,-0.05210236,0.025696166,-0.015601878,0.024884697,0.00052995636,-0.04427122,0.014116843,0.055390436,0.12870437,0.009864031,0.016093615,-0.0015565923,0.03949798,-0.027697822,-0.09959808,-0.014071619,0.00014654556,-0.026282929,0.074373156,0.018071622,-0.09189756,0.04610499,-0.042560365,4.052208e-34,0.06727833,-0.031452063,0.045919932,-0.021368563,0.05508776,0.028567526,-0.08511431,0.004216311,0.09933856,0.016466415,-0.061397966,-0.024230378,0.090286866,0.025811883,-0.077127084,0.05367088,-0.049239676,-0.018499615,0.04815391,-0.057672836,0.007197487,0.058056884,0.021339467,-0.0061505563,-0.009189121,0.0702588,0.05782765,0.014461194,-0.06050548,-0.024277983,-0.015946368,-0.08752508,-0.059343077,0.004941295,0.04933448,0.0045412397,-0.04365202,-0.072413504,0.026698042,-0.019886065,-0.07010907,0.052023824,-0.06926298,-0.029574692,0.059700344,0.020668559,0.035324167,0.069684505,-0.07061317,-0.008628428,0.085177645,-0.073328465,0.008205016,-0.011590694,-0.028181065,0.03405777,0.018950325,0.032098662,0.03688752,0.12095037,0.111109056,0.10037912,0.02326993,-0.002762927,-0.034468874,0.015573454,-0.04329771,-0.059771914,-0.020871755,0.026888615,-0.0389165,-0.05172293,0.07909695,0.011023908,0.053503253,-0.07578962,-0.051112812,0.03091525,0.023718083,-0.04646408,0.022946415,-0.023183312,0.0026264458,-0.017984789,-0.0011214619,-0.058308583,0.031457704,-0.113312475,0.011253214,0.06025852,0.0056205564,-0.028222464,0.073131606,0.0009905341,0.035863005,-2.1604923e-33,0.027235033,-0.13300893,-0.04466361,-0.01577873,-0.016168652,-0.0043610716,0.04832364,-0.057525042,0.024442062,-0.00079779024,0.055995956,-0.029196477,-0.012637811,0.006530534,0.08777798,0.013219446,0.044137627,0.05574425,-0.0009267322,-0.02176887,-0.019757383,0.032641213,-0.039201938,0.010353123,0.08567382,0.02666479,-0.025993282,0.082065344,0.09629559,0.0011748001,0.039518688,-0.0049620443,-0.014167993,-0.04074292,0.014458353,0.06278694,-0.066028945,0.0030244247,0.01861656,-0.031144984,0.06456343,0.02845056,0.11656872,0.06722108,0.027017849,-0.038102444,-0.12255531,-0.11705131,-0.0069469516,-0.071168765,0.016307458,-0.024787435,-0.062050104,-0.04042616,0.061587814,0.0751599,-0.0015610682,-0.01055254,0.0399541,0.01223656,-0.041296896,-0.11292403,0.05640443,-0.024187436,0.0015746497,0.04691926,-0.015423482,-0.028799532,0.10387167,0.008321661,0.10398893,0.0058422363,0.026492823,-0.00034935362,0.00016833904,0.0012217446,-0.056958,-0.0127473315,0.0008090287,-0.075842366,-0.039999023,0.010979974,0.047426578,-0.05911086,-0.03808195,-0.079296574,-0.050304677,0.117395334,0.004072413,0.015759716,0.027256517,-0.07841579,0.05263629,0.019138426,0.16785365,-3.171825e-08,-0.0036146005,-0.027092053,0.10615714,0.07296487,-0.060016163,0.0036800674,-0.009896479,0.010655701,-0.02597953,-0.06448848,0.043281,0.046011195,0.03714816,0.004707224,0.0026185198,0.0900131,-0.08339033,0.047695722,-0.007145311,0.048674952,-0.09767844,-0.01582819,-0.09497254,0.049621284,0.009810853,-0.059238836,-0.04029288,0.028162714,-0.03819557,-0.03561103,0.054917645,-0.00069613644,0.028695477,-0.01616579,-0.050453763,-0.061390877,0.034935534,-0.023000566,0.0077486974,-0.036516614,-0.06305838,-0.034334008,-0.08145107,0.07011244,0.0080111995,0.015456593,0.033039648,-0.046107464,-0.0690733,0.027059695,0.10774101,-0.034026805,0.002800145,-0.026616542,-0.0010916801,0.035377007,-0.06061633,-0.012211148,-0.03196129,-0.014128762,-0.011377482,0.06351819,0.122982755,-0.030625166 +1.5.1.17,"In the reverse reaction, L-alanine can be replaced by L-cysteine, L-serine or L-threonine; glycine acts very slowly (cf. EC 1.5.1.22 strombine dehydrogenase).",384,1.0,0.0052803084,-0.036341526,-0.05277993,-0.04322702,0.059036102,0.08965256,-0.110463165,0.051569697,0.039649755,0.04812508,-0.0016954307,0.06496592,-0.07673719,-0.015721768,-0.011319584,0.010958452,-0.008223764,0.029098468,-0.045972034,-0.050199933,-0.03723612,0.044916242,-0.06491269,-0.0101828305,0.06598669,0.04448693,-0.036678933,0.013231765,-0.016458616,-0.075308755,-0.01033383,-0.06479425,0.037514247,-0.025623664,-0.10015219,0.09248438,-0.083032414,-0.019248484,0.0538157,0.04304535,0.017460292,0.018273976,-0.05105399,-0.070338294,-0.06695857,-0.03715922,-0.045532778,0.021848813,0.02279324,0.0943755,0.037365373,-0.031911746,-0.0342214,-0.0037685996,-0.018190943,0.020986788,-0.10575007,0.043838553,-0.0052068816,0.018556789,-0.019023806,0.05760107,-0.052356515,-0.020534342,0.026230235,-0.024764169,0.065470085,-0.09613353,0.08436396,0.0061696637,0.0146686975,-0.06331347,-0.034952473,-0.017035823,-0.042266443,0.029730318,-0.05607379,0.027511625,0.009995865,0.0071092104,0.052771565,-0.010475461,-0.008720433,0.044334862,0.03397751,-0.009398653,-0.054674864,0.041776706,0.052166466,0.0034658313,0.03956008,-0.008700582,0.038393732,-0.0035335904,0.023744578,0.008591851,0.028373225,-0.0013353513,-0.029099302,-0.02671606,-0.026079275,0.12129377,-0.075161405,-0.0133967735,-0.031198028,-0.013184321,-0.011671582,0.08195875,-0.07847369,-0.08991813,0.08014747,0.013549397,0.07536388,0.036097642,0.021266615,0.063488096,0.08108792,-0.015649067,-0.060356636,-0.011823748,0.03970826,0.015555175,0.028725205,0.0414772,0.008895088,0.09548338,-0.03597003,1.3580397e-33,0.052957676,0.037186336,0.0629728,-0.011712023,0.014805568,0.0069556776,-0.059862398,0.08705122,0.07491868,-0.02119904,-0.0017965864,-0.0075781518,0.044230305,-0.03726577,-0.053073443,-0.040824935,0.047359996,-0.014333833,0.08186466,-0.008392025,0.0017425567,0.03430954,-0.031747878,0.018791048,0.001182949,0.047166083,0.0891229,0.017048977,0.03585854,0.0019117107,-0.053429782,-0.03925325,-0.05600998,-0.031527568,-0.020356743,-0.049334504,-0.09856225,-0.01777056,0.075234,0.04489968,0.032357547,0.04242836,-0.06401494,-0.006867241,0.0141023155,-0.045929097,-0.0040346133,0.048346054,-0.039247904,-0.0072802105,0.10030885,-0.013585487,0.015003116,-0.035099637,-0.09084123,0.022419449,-0.012449414,0.059777647,-0.002433404,0.1513346,0.07460993,0.06900467,0.0046976586,0.068193935,0.036609493,-0.03952557,-0.07170288,-0.09414619,-0.05400072,0.036935717,-0.031546105,-0.07419771,0.12998737,-0.013037446,-0.004670823,-0.050771385,-0.05049728,0.031286187,0.03165072,-0.05530361,-0.01300257,0.06209068,-0.07622401,0.029339502,0.0002480559,-0.07363094,0.02832041,-0.13224427,0.0016035897,0.008276749,0.019726807,-0.070940584,-0.0018379928,-0.0034661368,0.05375337,-2.4251997e-33,0.044232734,-0.13856295,0.011847773,0.020134104,-0.06035246,0.056631476,0.057741135,-0.03043469,0.03348648,0.024584152,0.082266785,-0.035408985,-0.03931856,-0.021134282,0.022583077,-0.015137868,0.022362085,0.002579597,-0.027473163,-0.024438107,0.03160021,0.05469427,0.09933879,0.04263594,0.11008441,-0.019115077,0.014907734,0.08980222,0.04438556,0.015863497,0.0138473,0.007288995,0.010077082,-0.055322055,-0.07403257,0.12480873,-0.012700182,0.0012682062,0.03272983,-0.010496146,0.027654998,-0.013290932,0.084391646,0.081817806,0.03828759,0.029361242,-0.10696605,-0.067330256,0.010510761,-0.06992796,0.015723389,-0.013140118,-0.06610704,0.026675306,0.011581914,0.020016905,0.0064875344,-0.04239601,0.019512987,0.044761732,-0.017751988,-0.047011048,0.019045448,0.0017149526,0.04823347,-0.009473465,0.0141113335,0.0048666564,0.08549242,-0.031125652,0.118699774,-0.0121029,0.07178487,0.08963543,0.030511178,-0.026941353,-0.018596096,-0.036341593,-0.01711969,-0.1253914,-0.029992737,-0.051740427,-0.015596367,-0.03799494,-0.019401815,-0.06562076,0.008883519,0.15786476,-0.03606329,0.06259737,-0.031318683,-0.07470523,-0.028187813,0.03534017,0.10111746,-3.2772274e-08,0.032734636,-0.092381984,0.061095256,0.008631285,0.0011441961,0.06345144,-0.052069135,0.06584657,-0.019212885,-0.08489121,-0.025735775,0.0030457238,0.027311852,0.015067366,-0.03261209,0.081931,-0.06276464,-0.011029865,0.0023428057,-0.0067179347,-0.12763916,0.004105907,-0.04488035,-0.027101465,-0.007555097,-0.045625538,0.011030752,0.032145128,-0.00036149006,-0.027195603,0.02166247,-0.008640062,0.03993029,-0.016230108,-0.042490225,-0.03326404,-0.0012214663,0.0034295593,0.003634112,-0.01670521,-0.08349409,0.021912895,-0.16100346,0.04696185,-0.015687298,-0.05281354,0.038318217,0.028735258,-0.07131685,-0.02551156,0.08192586,-0.019743662,0.015096134,-0.050096836,-0.017145805,0.016415123,-0.07768223,-0.09169188,0.025747355,-0.015001059,-0.043919135,-0.021372797,0.083467215,-0.047325093 +1.5.1.18,"The product immediately hydrolyses to methylamine and 1-hydroxy-1-phenylpropan-2-one. Acts on a number of related compounds including (-)-sympatol, (+)-pseudoephedrine and (+)-norephedrine.",384,1.0,0.0030375673,-0.054402232,-0.023370806,-0.070167966,0.0521144,0.051906988,0.047757998,0.008043864,-0.019656138,0.04564723,0.052722815,-0.04706139,-0.0031105718,0.03960254,-0.043885566,0.048188154,-0.044681218,-0.05622691,0.034869466,0.03960771,0.04728695,0.008321735,0.013653551,0.017648803,0.01716816,0.09101856,0.025018832,0.066259846,0.076041825,-0.00751965,0.073055066,-0.0030520326,0.015532464,-0.032537468,0.05501308,0.032252587,0.028331384,0.02082574,-0.042568427,0.029608833,0.058829907,-0.08890775,-0.04566723,-0.05968097,-0.025043437,-0.025920426,0.0077480907,0.051018976,-0.0026294594,-0.027057778,0.0022135174,-0.027479136,0.0012150111,0.123437166,-0.04054946,0.104633786,-0.06275997,0.03989291,-0.07588828,0.05736242,-0.06325897,0.034524463,-0.060991086,-0.0230273,0.016715614,-0.01593526,-0.050386567,-0.008961804,0.05706593,0.05934081,-0.05196602,-0.055868708,0.013362114,0.0052908747,0.008555692,-0.06047557,-0.0010459076,-0.048104722,0.045885712,-0.11941192,-0.0493542,-0.010040546,0.03578364,0.037752923,0.041975398,0.009391805,-0.016927153,0.040923875,0.07334614,-0.010530441,-0.04489005,-0.01324692,-0.008780739,-0.018013619,-0.059371464,0.04120632,-0.03834949,0.053809308,0.02000806,0.060553897,-0.004805318,0.009110651,-0.10382842,-0.13069198,0.0019532037,0.0015079555,-0.017777551,0.001151119,0.010417978,-0.011786645,-0.05207039,0.011589892,0.012177562,0.036945675,-0.033848803,0.06818849,0.025297826,-0.01361181,0.00885415,-0.12363651,-0.013852215,0.014754699,0.02160767,0.06491714,-0.038595453,0.033166643,-0.037447203,6.595899e-34,0.03491378,0.032100778,0.029938174,-0.0076084235,-0.042994935,0.07507785,-0.06725468,0.06069232,0.04093179,-0.006835285,-0.060892697,-0.036100287,0.03148533,0.05954024,-0.025617791,-0.11172253,0.023121765,0.0091858655,0.121590905,-0.0466695,-0.05702952,0.12265234,-0.08859975,-0.00036148803,-0.031539503,-0.0057324427,0.024415819,0.020702276,0.042607363,-0.0120962,0.03407492,-0.012049103,-0.124350205,0.010076196,-0.07636973,0.042124584,-0.041978437,-0.049775027,0.02969922,0.03377282,-0.026612332,6.503702e-05,0.01872431,-0.026712218,-0.0035184196,-0.015011624,-0.034681354,0.0609576,0.022897163,0.03663269,0.009407552,0.012814888,0.06716096,0.03798943,-0.14261895,0.0007515955,-0.03463898,-0.04098336,0.038539413,0.0850263,-0.02074727,0.024967594,-0.02291964,-0.021556925,-0.028201984,-0.009244714,-0.0036476874,-0.066866465,0.0039692586,-0.001591687,-0.09025617,0.03048784,0.08532579,-0.006769079,0.072642475,-0.0043519135,-0.029157024,-0.0068142526,-0.058928177,0.035688464,-0.052217815,-0.032926902,0.014694365,0.08359807,-0.068640225,0.021895144,0.017822664,-0.07897497,-0.03932875,-0.01260205,0.024259811,-0.1474468,-0.034815017,0.04550194,-0.03671164,-1.5555598e-33,-0.02535748,-0.082656704,-0.02500435,-0.037697997,0.015983433,-0.019785453,0.02375092,-0.044315033,-0.06510295,-0.019841159,0.0796442,-0.02890084,-0.010732775,-0.04502815,-0.038935646,0.080536425,0.030811906,0.02481629,0.0067224884,0.021671368,0.07101453,0.07050761,-0.04649374,0.11977317,0.05331773,0.022753064,0.16761743,0.046443783,0.0706031,0.11020187,0.0042551053,0.0052878754,-0.0332037,-0.08800399,0.0294242,0.0701344,-0.08318663,-0.06965298,-0.07012771,-0.03900625,0.0038112334,0.00446645,-0.011524209,0.051929805,0.0627512,0.05571672,-0.09802055,0.014527292,-0.101171136,0.015034999,-0.073284864,0.0175098,0.020225305,0.0028300988,0.028695388,0.0071688527,-0.029861685,-0.041926812,-0.028157748,-0.061658178,0.010642088,0.0013435084,-0.047800966,-0.029784746,0.054667193,0.0065265126,0.01971283,0.024820963,0.07140665,-0.011058591,0.094728515,0.043991145,0.04883779,0.04022137,-0.06360039,-0.033100825,0.03835046,-0.08143161,0.0013161835,-0.024536144,-0.0004650037,-0.06779951,0.05376862,-0.06477742,-0.044734105,0.006137659,0.010758501,0.06483748,-0.049814656,0.046989016,0.023827229,0.06701282,-0.101175725,0.10720998,0.037065726,-3.8509707e-08,0.041559514,-0.15363833,0.08510045,-0.050654124,-0.024211118,0.035688054,0.042548046,0.0149992015,-0.040860172,-0.038381465,-0.0075039878,0.057735987,0.013533701,0.0037515594,-0.012146854,0.08213363,-0.0066820118,0.063101105,-0.075064264,-0.06134263,-0.077493675,0.0070286607,-0.045992974,-0.02042379,-0.021588342,-0.018161485,0.018066509,0.041998427,0.07547967,-0.020919265,0.024092572,0.050641265,-0.0054985876,-0.047938123,0.029758416,0.08435895,-0.015608767,-2.5054235e-06,-0.02201924,-0.03864042,-0.002778248,-0.0008403353,-0.0074825906,0.03753303,0.11716786,-0.02813804,-0.0076376074,-0.0036121989,0.054801095,-0.043396216,0.04735188,0.044171672,0.012448782,-0.038225744,-0.10080181,0.022787912,-0.109763235,-0.09755983,0.014187907,-0.0098501155,-0.020875841,0.06086279,0.12668426,0.031061657 +1.5.1.19,"In the reverse direction, forms D-nopaline from L-arginine and D-ornaline from L-ornithine.",384,1.0,-0.05427818,-0.068369076,0.0039741946,-0.041353773,0.0036851948,0.049533956,-0.03788513,0.011668844,0.040320355,0.041070893,0.0403218,0.025132928,-0.0031587908,-0.025795793,-0.046341926,0.10515623,-0.054421656,0.025979375,0.017624708,0.045907985,0.0761398,0.10379155,-0.028357897,-0.027968133,0.07276385,0.0324729,0.03556775,0.0016020123,0.070879124,-0.10772385,0.04262674,-0.01570279,-0.053018324,-0.028858433,-0.017282525,-0.054843996,-0.07353197,0.056460552,0.02747446,0.07508368,0.0078348825,-0.028805459,-0.112207726,0.0015252735,-0.061745565,0.0044429004,-0.11913299,0.067937255,0.03606777,0.059064627,-0.0010903887,-0.06829627,-0.046525333,0.05281865,-0.031849857,0.015225006,-0.11256735,0.019728428,-0.011923311,0.0592474,0.037918564,0.072895825,-0.021844007,-0.008873318,0.05233079,0.017631834,0.020550044,-0.027875554,0.025032965,-0.014508869,0.02623047,-0.025709568,-0.009916255,-0.02092329,-0.005120302,-0.025848066,0.012306111,0.0031659286,0.002892955,-0.042651705,0.019282691,0.12425496,-0.025837999,0.12120054,-0.029024107,-0.014100958,-0.035007346,0.06363137,0.051001854,-0.058358043,0.011087743,-0.074898355,-0.067359775,0.009531051,0.002300883,0.0045345505,0.017416818,0.05464363,0.017105065,-0.01285164,0.0029230984,0.011395632,-0.14034237,-0.0777076,-0.05834384,0.020484895,0.012444548,-0.05379994,0.006432875,-0.03734646,0.008715631,-0.041789267,0.049813565,0.030617101,-0.1347153,0.018202867,0.016878057,-0.0015064701,-0.016810792,-0.039705183,0.0007070556,-0.021776916,0.0074151023,0.14250278,-0.03422075,0.09881519,-0.027541688,1.2121362e-33,0.07044707,0.034565732,0.09589672,0.02102537,-0.010918436,0.015872981,-0.054620985,0.0140016,0.042313166,-0.061321802,-0.07920566,-0.082483046,-0.023072505,0.017874828,-0.06385294,-0.05765151,0.022020554,-0.021497665,0.03112009,-0.021754956,-0.014329828,0.15373582,-0.10708483,0.02481412,-0.007873713,0.012355048,0.0865144,0.009898683,-0.0031729788,-0.023784775,-0.006650737,-0.09046589,0.00060078176,-0.010417223,-0.025099376,0.04552902,-0.007106973,-0.022287156,-0.0070479927,0.049184915,0.0039021282,0.014748752,-0.048282325,-0.019875577,0.019861653,-0.0007450049,-0.07461133,0.04014246,-0.06045437,-0.004477149,0.04078599,0.017323066,-0.02471442,-0.024911573,-0.091756344,-0.012791108,-0.07662289,0.020502754,0.01996629,0.032995295,0.03917444,0.018868988,0.008065455,0.005885498,-0.026465245,-0.03421655,-0.08034575,-0.08084451,-0.021431342,-0.03011789,-0.10771282,-0.0025890935,0.09451263,0.016866503,0.046310943,-0.0025655096,-0.109157726,0.056675278,0.0703151,-0.07317019,-0.020454485,0.0032632512,-0.007509391,0.023919152,0.00954889,-0.066228025,-0.011638285,-0.08336199,0.016547443,-0.016733652,-0.029867059,-0.042692512,-0.057268795,-0.0214688,0.024902109,-2.1282603e-33,-0.044929452,-0.08510262,0.028577233,0.012405698,-0.01224765,0.049149103,0.053839397,0.060310733,0.063572355,0.019993342,0.03627944,-0.01249859,-0.035183746,-0.102149926,0.043392044,0.02948445,0.030394122,0.12260801,0.001469338,0.045270428,-0.068037905,0.03673753,-0.052554898,0.017171443,0.05267147,0.06838962,0.066763684,0.044998728,0.04005841,0.08180852,0.070159405,-0.015756665,-0.0021130566,-0.03196797,-0.039152004,0.08758759,0.011832245,-0.010521433,-0.067787044,-0.0734478,-0.08259097,0.0048048934,0.1173969,0.0053558666,0.017169632,-0.014070908,-0.055366635,-0.0608346,-0.01311704,-0.09441157,0.054114543,-0.01687614,0.029918782,0.01578408,0.01790548,0.025129976,0.025022624,-0.008562948,0.04758648,-0.004255588,0.008547054,-0.04034595,0.000872702,-0.020818433,0.018117584,0.019240135,-0.0251677,0.08975773,0.0073611056,-0.096838385,0.009741146,0.0037468143,0.02744216,0.05522047,0.015261682,-0.031255916,-0.0062819384,-0.1123506,0.009312077,-0.001974811,-0.07746702,-0.03132501,-0.06738018,0.027575485,-0.058213644,0.027576346,0.04403016,0.08508161,0.018565606,0.066310726,-0.025382476,0.0049910257,-0.08390716,0.05303079,0.15869918,-2.5536801e-08,0.089912795,-0.103043616,0.058648918,0.036167976,-0.02664181,-0.053284217,0.071784146,0.050409093,-0.009129199,-0.052899268,0.027080018,0.09419037,-0.007794146,-0.015100467,0.075996794,0.040838063,0.032808624,0.03871361,-0.020510942,0.042628534,-0.046440516,0.016185848,-0.0048450115,-0.074203454,0.005693149,-0.04450897,0.07769694,0.045040216,0.06988862,-0.024526801,0.0034561045,0.026950926,-0.03021176,-0.06578967,-0.055837367,0.021677308,-0.008500582,-0.008157352,0.0684931,0.022755673,-0.059097577,0.009699162,-0.0027132938,0.024352763,0.055548664,-0.06889438,-0.008762931,0.04403021,0.00016306936,-0.03875728,-0.015148669,-0.03401535,0.030106869,-0.08713223,-0.08603757,-0.001842801,-0.08834158,0.012368098,0.006788017,-0.07005422,-0.0109815,0.034102663,0.12656558,0.07405098 +1.5.1.20,"A flavoprotein (FAD). The enzyme catalyses the reversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. This enzyme, characterized from Protozoan parasites of the genus Leishmania, is unique among similar characterized eukaryotic enzymes in that it lacks the C-terminal allosteric regulatory domain (allowing it to catalyse a reversible reaction) and uses NADH and NADPH with equal efficiency under physiological conditions. cf. EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).",384,0.99999994,-0.028543454,-0.01446013,-0.11805431,-0.055384465,0.08567032,0.01170583,-0.08149719,0.039528053,0.028162649,0.016141448,-0.0063551315,0.01646852,-0.041053243,-0.008030025,-0.087754086,0.029975317,-0.04843343,0.028870821,-0.01814037,0.01180154,0.023574995,0.020323018,0.06491934,-0.011705541,-0.026423845,0.02660711,0.021057243,-0.055981837,-0.07078071,-0.07927878,-0.031910334,0.023697574,0.01763063,-0.027104886,-0.07533899,0.091470025,0.04010088,-0.022738477,0.010317506,0.014205864,0.008505873,-0.033504188,-0.013737897,-0.04084691,-0.04524526,-0.038391594,-0.00027029894,0.07324152,0.036247354,0.054124475,-0.035612334,-0.012507369,-0.07263024,0.07267246,-0.0077316733,0.0020456987,0.025213456,-0.028775746,-0.04664681,-0.024709897,-0.048202522,-0.04207605,-0.028880471,-0.046272255,0.061293297,-0.10526522,-0.00010925391,-0.05830003,-0.029349573,-0.0013609127,-0.041956976,-0.03508328,0.012778345,0.056752384,-0.027764859,0.08046793,-0.010926862,-0.0023566438,0.061475098,0.056126773,0.054088455,0.037506983,0.06916232,0.025411593,0.06838792,-0.024693705,-0.06097355,0.069438174,0.06662603,0.07514942,-0.0051031266,0.028870914,0.02543964,0.010856986,-0.10584865,0.022351073,0.0820405,0.010671959,0.012702983,-0.05833864,0.031170161,-0.02158184,-0.0017758465,-0.025944943,-0.049034975,-0.011413433,-0.058301244,0.12660399,-0.033372555,-0.03851451,-0.030316353,-0.01107013,0.039173342,-0.026956372,-0.018672924,0.049329042,-0.022890104,-0.114305064,-0.06299008,-0.01604199,-0.015750663,0.038939636,0.087213874,0.054209482,0.05340093,-0.032486018,-0.11305166,4.7483316e-33,0.057577107,0.06566748,-0.005582001,0.03926898,0.023595987,0.036490988,-0.068010405,0.085258245,-0.008541806,-0.050925817,-0.03716729,0.0066148844,0.07364485,-0.03990682,0.022343269,0.010643559,0.020111391,-0.05503142,0.04214845,-0.083686925,0.035340123,0.013304101,-0.03709362,0.002821361,0.056538295,0.046657935,-0.055309206,0.02689655,-0.044799358,0.0042409194,-0.005969098,-0.11339411,-0.07710571,0.016204063,0.051437702,0.03553236,-0.027852373,-0.07011938,-0.07943511,0.04600113,-0.029179377,-0.021923132,-0.029158149,-0.03051149,0.05614397,-0.06384353,-0.06346859,0.08156556,0.0008761804,0.08332824,0.08686071,-0.028210003,0.13726035,0.030235248,-0.09083212,0.05547745,-0.040560834,-0.053272687,-0.01992784,0.056737516,0.017151171,-0.008005804,-0.044263817,0.07754154,-0.059101176,-0.0060784398,-0.050041016,-0.0419183,0.01597313,0.115383804,0.029149104,0.0026724755,0.09120242,0.0007851744,0.062480967,-0.004278276,-0.019732445,-0.05230946,-0.005844634,0.047643088,0.00291336,0.00092030974,-0.033544227,-0.028224953,-0.052192125,0.07720953,-0.0046813567,-0.038344394,-0.026225466,-0.004822092,0.07841696,-0.09366114,0.011043797,-0.07077492,0.019788653,-5.099286e-33,0.09063035,-0.09377814,0.011310954,-0.07645995,0.018127022,0.049277246,0.05895104,-0.021491311,-0.01015982,-0.11495602,0.006884363,-0.049116887,0.018899167,0.016959801,0.041805822,0.011248073,-0.06592822,0.028299298,0.06949173,0.017785998,-0.078995354,0.059462357,-0.020203605,0.07404909,-0.015871035,-0.036929417,-0.029143373,0.05262304,0.060345154,0.046308827,-0.049763512,0.007378744,-0.039360926,-0.031018717,0.017229395,0.10141093,-0.09338914,0.037359364,0.023589706,0.11942218,-0.031700477,0.0126352655,-0.059790753,-0.011708827,0.058380336,0.0641029,-0.09507389,0.023403613,0.0741487,-0.04732331,0.0822496,0.052275572,-0.008823159,0.048411854,0.04760199,-0.0012178783,0.003854734,0.035908863,0.06136025,0.0051972624,-0.011477542,-0.08457044,0.0044329762,0.015703373,0.09297935,0.0228886,-0.0035307065,0.10984568,0.04092513,0.046131067,0.104208805,-0.0023584142,0.051648315,0.086979166,0.056397848,-0.04035329,-0.037249316,0.04009795,-0.039405085,0.07005124,0.032099243,-0.00844255,0.052021723,-0.012778927,-0.072022125,-0.010018582,0.026394011,0.027697582,-0.072606064,0.023522982,0.022534627,-0.0012530497,-0.029747894,0.023612281,0.04044157,-4.832313e-08,0.055183172,-0.053595312,0.005530094,-0.04416784,0.045278158,0.07782368,-0.00025127328,-0.06439227,0.024096837,-0.0060566803,-0.07452655,0.093328275,0.04641631,0.020242725,0.020259144,-0.020500954,-0.040142212,0.03549405,-0.018053874,-0.0019204825,-0.10394459,0.05924749,-0.15342437,0.020012464,-0.0124974325,-0.019304655,-0.0047015534,-0.030557498,0.09248889,-0.019337125,-0.0376307,0.045634348,0.0495276,-0.055163722,-0.14280432,-0.002865874,-0.019341547,-0.043538544,-0.03110511,0.038542517,0.012240357,-0.01286497,-0.045108072,-0.0022530337,-0.022458205,-0.03431772,0.07763579,-0.010250454,-0.012619922,-0.051673174,0.001191973,0.05729917,0.003499645,-0.06707193,-0.041762173,-0.03618055,-0.057169672,-0.053744327,-0.029186362,-0.06317855,0.018613577,0.041513257,0.110762395,-0.052028015 +1.5.1.53,"A flavoprotein (FAD). The enzyme from yeast and mammals catalyses a physiologically irreversible reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADPH as the electron donor. It plays an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. The enzyme contains an N-terminal catalytic domain and a C-terminal allosteric regulatory domain that binds S-adenosyl-L-methionine, which acts as an inhibitor. cf. EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).",384,0.99999994,-0.030403504,-0.028096851,-0.119888745,-0.018910224,0.10471913,0.042160075,-0.088617384,0.037708316,0.031347785,-0.0024440335,-0.035612397,-0.0019055558,-0.041387692,-0.019058887,-0.06602532,0.03908023,-0.091343075,0.00083506113,-0.016072687,0.0033055302,-0.0039054279,0.04875481,0.010204382,-1.726615e-05,0.0046740198,-0.026530514,-0.0050666314,-0.03875819,-0.08194314,-0.060821142,0.013607918,0.019295242,0.06746437,0.019079296,-0.042335,0.12311411,0.03017225,-0.0259511,-0.0021502206,0.02644759,-0.022036076,-0.051109258,0.002318259,-0.02609848,-0.0030651572,-0.0064724935,0.009010132,0.031785622,0.025573881,0.06081977,-0.030883972,-0.01883662,-0.06529862,0.016559286,0.017878707,0.038875718,0.0514437,-0.018134788,0.0017921376,-0.008183821,-0.013284176,-0.09244691,-0.009718501,0.00030345918,0.07593732,-0.06576786,0.034989253,-0.11170793,-0.0054073646,-0.041245453,-0.022558842,-0.031890783,0.0144519005,0.014704121,-0.0008787057,0.07596235,-0.042738084,-0.026407942,0.058986813,0.020189824,0.07038545,0.028734863,0.069203205,0.028464768,0.08580525,-0.03378982,-0.07840973,0.009397823,0.010673561,0.064302586,-0.03423873,0.0046602827,-0.0031758798,0.024962617,-0.113142766,0.03178993,0.090804204,-0.022154545,-0.03648066,-0.03196122,-0.018159017,0.029492691,-0.028643532,-0.018029006,-0.057762966,-0.02831828,-0.031337187,0.10034382,-0.08147343,-0.029872797,-0.0060380446,0.010178347,0.017296612,-0.014329228,-0.02371346,0.0551451,-0.0078684855,-0.10821123,-0.06047121,-0.013447982,-0.05039225,0.057697717,0.06811137,0.057222776,0.022829922,-0.064044625,-0.09248363,4.7325156e-33,0.074515894,0.096490726,-0.060884405,0.017898675,0.046219066,0.009896619,-0.04648208,0.07765532,0.020210128,-0.034694355,-0.010512703,-0.017413506,0.08442783,-0.04443406,-0.02231222,-0.01594762,0.021757875,-0.072422616,0.060376838,-0.10194937,0.028290575,-0.02195993,-0.011752978,0.033308033,0.029560318,0.011095059,-0.06543146,0.07045177,0.03388369,0.015700128,-0.018887432,-0.0628507,-0.083828494,0.003784285,0.047121394,-0.0037878542,-0.07874252,-0.034603387,-0.03957616,0.10574871,-0.013915047,-0.0029297362,-0.030521205,-0.049409695,0.051747408,-0.026242282,-0.06858968,0.0707679,-0.0038936357,0.10690853,0.0584554,-0.06544895,0.09990749,0.015504572,-0.09577065,-0.008509391,-0.06408033,-0.085882954,-0.08188568,0.074850276,0.0013310144,-0.0067860545,0.00036234286,0.076334685,-0.069708444,-0.011995534,-0.05490304,-0.07437601,0.012722944,0.09705257,0.0515804,0.023350254,0.14083977,0.008596777,0.040320355,-0.0021671471,-0.03624204,-0.009605403,0.010362046,0.040162414,0.035891417,0.024962636,-0.031690814,-0.0376858,-0.034460355,-0.0030376718,0.0012658116,-0.08274265,-0.0011507976,-0.035837706,0.054283448,-0.13017328,-0.003756795,-0.068374895,0.05598691,-5.005654e-33,0.102694936,-0.066149905,0.07302624,-0.063491866,0.005751158,0.07527572,0.08321317,-0.083148755,0.005399717,-0.08293667,0.05500011,-0.025835603,0.019188682,-0.017380316,0.030004686,0.003822431,-0.02457144,0.008315857,0.036868744,0.004604739,-0.03498336,-0.0040818094,-0.036996007,0.062021848,0.044566885,-0.020044893,-0.057311878,0.00051454216,0.078402035,0.05837444,-0.04092629,0.0066959714,-0.0783341,-0.018047819,0.016363867,0.11481868,-0.10242803,0.059626155,-0.0171758,0.0721504,0.0132222865,0.0189622,-0.03477821,0.011472013,0.06949135,0.09096208,-0.08366288,0.031012625,0.055206977,-0.055198558,0.071409225,0.0360948,-0.010767097,0.040514395,0.047622256,0.048393503,0.06883189,0.04769901,0.020294875,-0.05314216,-0.023093406,-0.081003614,-0.0055534197,0.019971887,0.046677273,0.027652306,0.021842146,0.07665567,0.061444953,0.068812065,0.08728994,-0.0031897998,0.0687321,0.079256535,-0.010848282,-0.022192843,-0.006251038,0.018219694,-0.07368128,0.033333693,0.063066445,-0.00013838713,0.028709223,0.007289879,-0.03269297,-0.027042417,0.035193115,0.043675076,-0.040996443,0.006435658,-0.03138536,0.052099824,-0.012028649,-0.02900193,0.09371659,-5.1548035e-08,0.041539807,-0.084635146,-0.024166381,-0.04928634,0.08450488,0.068597145,0.016211892,-0.05978136,0.0054857302,-0.03164134,-0.09574931,0.13775054,0.008623984,0.011946838,0.009745288,-0.029503098,-0.025646752,0.036820747,-0.0020737525,0.007540926,-0.11146377,0.0357945,-0.16134438,0.0046467744,0.0053967834,-0.045256305,0.0012601177,-0.043421436,0.07882168,-0.0077267266,0.06265239,0.012765455,0.035198174,-0.050552767,-0.10921398,-0.011654566,0.023782544,-0.041631967,-0.050008032,0.041315164,0.004354616,0.009806672,-0.024580238,0.017427409,-0.024903795,-0.013194787,0.023928678,0.020847302,-0.011022185,0.006976029,-0.0017974664,0.036512036,-0.025647841,-0.03364402,-0.055892896,0.0034153801,-0.032875784,-0.06734658,-0.009100899,-0.041671574,-0.011767474,-0.0011702869,0.10871566,-0.068048365 +1.5.1.21,"The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH.",384,1.0,-0.04613239,-0.06711811,-0.06463395,-0.034108434,0.0335914,0.09514481,-0.07065067,0.08451411,0.020337773,0.0052927188,-0.03074217,0.0005889995,-0.06583496,0.059225712,-0.050074853,0.0039333147,-0.08908926,-0.030820884,0.0139706135,0.0054317815,0.03363893,0.06295341,0.012249507,0.006756367,0.059707295,0.010031428,0.07984185,0.051063973,-0.060328364,-0.045714155,-0.051577423,-0.05832855,0.05338973,-0.03371402,0.07399243,0.025707606,-0.026166497,0.027736066,0.040460914,0.016563097,0.023990603,0.02105304,-0.052646186,-0.031371485,-0.04536041,0.014587373,0.0056322142,0.08662422,0.039592255,-0.027127415,-0.018141897,-0.024800414,0.025046354,0.05969499,-0.027000485,0.038516946,0.056228187,-0.0020046325,-0.049099833,-0.087209776,0.016547415,-0.02901914,0.04004913,0.019498382,0.04333466,-0.045965135,0.03495977,-0.04750382,0.016896611,-0.11340712,-0.12477004,-0.07082385,0.04682912,0.050418552,0.019363321,-0.029754488,-0.023415446,-0.06262075,0.01648526,-0.04045133,0.034873243,0.0034721226,-0.03165819,0.06480164,0.015317241,0.022009488,0.018756106,0.012886953,0.06031173,-0.06241718,0.013073644,-0.088861495,-0.06701786,0.023323359,-0.1725173,-0.016416116,0.0331354,0.069283925,0.0114972945,-0.06387355,0.013671432,0.074871376,-0.02573509,-0.071570784,-0.05737024,-0.0031934245,0.00591102,0.10708679,-0.005885667,-0.047322173,0.011882772,-0.038413994,0.016373975,-0.0017165006,-0.04772719,0.06491334,0.044137023,-0.023475306,-0.09985998,-0.043212406,0.01937034,-0.0481448,0.062924996,0.06326937,0.0056954473,0.00903144,-0.13343006,2.821314e-35,0.0932501,0.0062116827,-0.01708992,-0.0023555371,0.051416192,0.008901676,-0.10273997,0.05009474,-0.01797726,-0.042816352,-0.03347503,-0.061590675,0.066714704,-0.03860004,-0.0052847373,0.04444787,-0.08529866,-0.04578319,-0.0018437053,0.018193884,0.03503902,0.09228312,-0.0054962737,0.06630694,0.04410317,0.023899311,0.021142863,0.0541338,0.0047195093,0.0041744807,0.0071479506,-0.14891627,-0.068704136,0.009384476,0.026355827,-0.014634313,-0.061936848,-0.04759765,0.0144100655,0.061234187,-0.024329543,0.03981379,0.018805549,-0.0435873,0.038374852,-0.11327462,-0.01965822,0.15871774,0.019020854,0.11004513,0.05626361,-0.06449299,0.12955655,-0.07064222,-0.041935835,0.025077531,-0.07683143,-0.0253895,0.046259284,0.10175661,0.08182874,0.042960566,-0.03378525,0.06282459,-0.022276351,0.015288218,-0.074580684,-0.036893126,0.05166649,0.06735038,-0.092873946,0.04439586,0.06590691,0.048734903,0.016915029,-0.050104085,-0.027183754,-0.0015954665,0.035412766,-0.008762027,-0.030465795,-0.025990594,-0.043736618,0.013385395,-0.05169853,0.0053124274,0.015837736,-0.06812957,-0.06561041,0.019636754,0.03045641,-0.027225142,-0.05475757,0.011440674,0.058859542,-2.0688243e-33,0.041558728,-0.029314904,0.058230635,-0.098206624,-0.008368525,0.08602872,0.031852465,-0.002801833,0.02423216,-0.06042737,0.019760946,0.06530358,0.0020757623,0.019274557,0.036752623,-0.0026373146,-0.03304991,-0.017837446,0.0001499004,0.008203426,0.031632803,0.05004643,-0.0071176914,-0.027113635,0.03867711,-0.032970414,-0.020056086,0.08768792,0.052321307,0.019578176,0.07667947,0.042793926,-0.026936857,-0.06033255,-0.055933993,0.08455512,-0.07010848,-0.012403204,0.017294487,0.018388405,-0.0062926565,-0.02555509,-0.05972993,-0.029434739,-0.005679225,0.05701654,-0.09561211,-0.006014849,0.032296225,-0.0992786,0.0063630235,0.018570641,0.020854853,0.018684028,0.017360525,0.04232259,-0.053796902,0.07224114,-0.02560678,0.024242695,-0.0022536628,-0.06440032,0.022318406,0.04109449,0.01910643,-0.06111693,0.0043743937,0.008037916,0.07120034,-0.013067143,0.10505066,0.03385046,-0.013900061,0.06796308,-0.10781726,-0.07453244,-0.031610817,-0.013924677,0.032271508,0.010802569,0.018521357,-0.027409663,-0.009717651,-0.03654006,-0.020972662,-0.018038971,0.012050466,0.10489765,-0.026006352,0.02122833,0.002207933,0.019733397,-0.020354437,0.010701539,0.031731952,-3.81544e-08,0.09542319,-0.045838255,0.05537963,-0.022516508,0.0069180513,0.016087726,0.028662963,-0.002574183,-0.013768779,-0.006901599,0.00693574,0.098102696,0.0068923566,-0.024164505,0.053646926,0.06654981,-0.075151406,0.017171586,-0.051402505,0.03371443,-0.041203387,-0.040825877,-0.14997257,0.012310535,-0.0047176853,-0.032717686,0.045263413,-0.0071269735,-0.025644023,-0.055086445,0.011048376,-0.02748541,0.08350804,-0.080671094,-0.04372219,0.016129484,-0.08828941,0.02474277,-0.03791507,0.046239667,0.06461166,-0.062457178,-0.033964496,0.030600829,0.008086538,0.026034886,-0.020503215,-0.021967089,-0.023251165,-0.018107923,0.053729028,-0.0061058896,-0.003391076,-0.048175532,-0.13147222,0.09354056,-0.034169916,-0.065927856,-0.025421804,-0.03467346,0.011984127,0.08754548,0.10856533,-0.014140151 +1.5.1.22,"Also catalyses the reaction of EC 1.5.1.17 alanopine dehydrogenase, but more slowly. Does not act on L-strombine.",384,1.0,-0.046967734,0.018913921,-0.061946597,-0.012008298,0.10109398,0.07225718,-0.04433524,0.050493352,0.008960107,0.026621567,0.014115312,-0.015269963,-0.11528127,-0.024256334,0.025148682,0.068194546,-0.033173714,-0.015410591,-0.017825698,-0.08882716,0.021718206,0.00059533713,-0.010132102,-0.022498725,0.051490016,0.08966511,-0.02179213,0.037461393,-0.008909231,-0.10810198,0.00049472234,-0.027406683,0.060106438,-0.021084862,-0.05984799,0.08717367,-0.060866814,-0.08375449,-0.009946381,0.043961193,0.041174155,0.025965627,-0.036904413,-0.054887034,-0.043261793,-0.07051135,-0.035102192,0.081213675,-0.06462866,-0.003949081,-0.01754889,-0.052842204,0.0019047238,-0.059266135,-0.00633694,-0.010573385,-0.12814474,0.014788487,0.0038154905,0.010835707,-0.015900442,0.05125659,-0.022672912,0.044224836,0.02434092,-0.013153347,0.09495973,-0.121293,0.07925977,0.010395375,-0.0054699043,-0.06514259,-0.04220415,0.028207788,-0.016250448,0.040560354,0.013949074,-0.03034616,0.035906658,-0.023330033,-0.029909888,0.028816447,-0.005894496,0.016213443,0.017199581,0.010882173,-0.024363825,-0.02402589,-0.0007908554,0.061423007,0.062359873,-0.044455446,-0.0032369616,0.028404102,0.016049143,0.052593473,0.05469348,0.020690594,-0.0607132,-0.043572493,-0.040269192,0.15733296,-0.11120238,-0.0025649862,0.00019632693,-0.044269774,0.022747012,0.077893265,-0.060742717,-0.09946079,0.053151365,-0.07048758,0.05799116,0.02892635,-0.007945921,0.0661628,0.043720294,-0.04950117,-0.006989355,0.027960483,0.074279994,-0.043161698,-0.0054402943,0.0891294,-0.038234614,0.03498391,-0.08635454,1.1107092e-33,0.049595226,-0.0055039315,0.014030976,-0.012124937,-0.003582987,0.020049263,-0.11005913,0.08677125,-0.028215999,0.038769882,-0.01074901,-0.022408722,0.09050269,0.014881413,0.01657054,-0.06221256,0.026153838,0.060450863,0.0657525,0.0044020424,-0.0028020372,0.0004112814,-0.056157958,-0.004289654,-0.042187914,0.08953014,0.03538912,0.020956678,0.074358955,0.02821167,-0.055284068,0.0030018196,-0.07082873,-0.01712806,-0.025934514,0.0074943257,-0.09545955,-0.043394033,0.032998744,0.06972969,0.024012467,0.042776402,-0.06120532,-0.008932076,0.02292973,-0.0797256,-0.06582782,0.041592833,0.033047814,0.06070477,0.061082225,-0.011600828,0.07848983,-0.026415791,-0.017016416,0.038821973,-0.0743476,0.038684502,0.03435095,0.12839754,0.023718739,0.06991941,0.0063397824,0.029346129,0.0437859,-0.00626571,-0.012073025,-0.098447435,-0.02475988,0.025247527,-0.057169236,0.0001273453,0.14678535,-0.037673835,0.04410288,-0.017258922,-0.030795852,0.029921241,0.039700553,0.02986076,-0.002526226,-0.0009745007,-0.03845593,-0.026680944,-0.01730659,-0.0026220004,0.005634754,-0.08067217,0.009979874,0.060457464,-0.0041968892,-0.07578329,-0.048745427,-0.014675233,0.048346046,-2.7308058e-33,0.05647268,-0.11046165,-0.009354448,-0.056716025,-0.052778993,0.09791853,0.053169172,-0.08032193,0.008929157,0.028427713,0.13613819,-0.022563133,-0.046255007,-0.037942227,0.06482505,-0.0292139,-0.004142911,0.051258184,-0.028950289,0.04712095,0.033488236,0.043630745,0.045997918,0.11763523,0.099149756,-0.016736282,-0.031855933,0.01799284,0.0260535,-0.015193593,0.008449543,6.950015e-05,-0.06313064,-0.052752562,-0.052853115,0.057101045,-0.03019703,0.053199705,0.068149894,-0.05296692,0.04004812,0.0183307,0.06555505,0.03593624,0.06904387,0.08413418,-0.04873998,-0.020254368,0.014531739,0.0075365067,0.0032166746,0.021984052,-0.08274805,-0.0024918243,0.00758571,0.013575071,-0.017145155,-0.05220012,-0.04015494,0.037647087,-0.016747914,-0.03437606,0.018941801,0.00045335112,0.04522249,-0.025887186,0.023594799,0.038200427,0.074074246,-0.04691809,0.14661622,-0.026980668,0.055060074,0.024512587,-0.030865612,-0.025587393,0.019585615,-0.09281383,-0.004557933,-0.12749568,0.027367199,-0.036402922,-0.008612426,-0.046522666,-0.03400617,-0.08552487,0.023522824,0.11514318,-0.022429178,0.08207914,-0.059954304,-0.086760275,-0.047086574,0.0148708,0.0837289,-2.7364768e-08,0.05000567,-0.031996377,0.04603517,-0.012185222,0.011262994,0.10322183,-0.030221937,-0.020955877,0.0071506877,-0.068391606,0.017178524,-0.0018591203,0.042525247,0.022619117,0.030505784,-0.015865587,-0.06272655,-0.027561236,0.016128633,-0.042862713,-0.090657115,-0.02454171,-0.04993237,-0.031154819,-0.024256136,-0.0665201,0.038913094,0.076474786,0.042053718,-0.042536274,0.0045387857,0.020181688,0.050650053,0.01993165,0.0064701852,-0.042637493,0.006549201,-0.009354959,-0.029089082,0.003127439,-0.060031883,-0.06329222,-0.077644296,0.0059594796,-0.054578666,0.019724982,0.042731375,-0.0071198326,-0.08558895,0.014943083,0.073060825,-0.009456939,0.028247792,-0.028997283,-0.046533354,0.01650913,-0.031681553,-0.1388764,0.032499645,-0.05247297,0.017425165,-0.030009389,0.10132523,-0.023451732 +1.5.1.23,"In the reverse reaction, alanine can act instead of taurine, but more slowly, and 2-oxobutanoate and 2-oxopentanoate can act instead of pyruvate.",384,1.0,0.034124933,-0.08528543,0.016244128,-0.0015872185,0.03036323,0.07921138,0.0048336126,0.04836427,0.06242105,0.06239443,-0.057043143,0.0061207227,-0.07766829,0.046237987,0.048432525,0.061618924,0.00023609935,-0.031660922,0.06194116,0.018923517,0.015031233,-0.03646429,0.019116193,-0.020239096,0.0010157665,0.05300576,-0.0009223221,0.06122224,-0.015788596,-0.05400781,0.022523819,-0.089855306,-0.03414363,-0.08976057,-0.086951084,0.08003453,-0.09706003,0.034579564,-0.026539428,-0.0130908815,0.1004665,0.076185286,-0.032968808,-0.00060343253,-0.013286566,-0.007112319,-0.015103406,-0.00508916,0.001572231,0.05554395,-0.00890203,-0.0146075385,-0.11178337,0.032321002,0.04465216,0.1220168,-0.11437888,-0.07761433,-0.058150876,-0.045003552,-0.03220811,-0.0066897203,-0.07710716,-0.06850416,0.033925496,-0.010964356,-0.009086602,-0.035863325,0.081531115,-0.031853504,-0.02457375,-0.018044693,0.050924428,-0.03085936,-0.0031551465,-0.03011716,-0.08161966,0.009813206,-0.039461795,-0.050929382,0.0030428013,-0.046548054,-0.06607749,-0.031711347,0.059444875,-0.014743829,0.013761705,-0.086623475,0.04059628,0.029676614,-0.012796503,0.027896201,0.065692574,-0.032280974,0.0917306,-0.05159755,0.062147558,0.054176647,0.007785051,-0.025210787,0.009066076,0.11018627,-0.099631734,-0.06768153,-0.039050613,0.0002877002,-0.03948434,0.013731915,0.018313088,-0.01133718,0.011060419,0.0025030405,0.06349111,0.05409059,0.07760212,0.09612968,-0.0037573471,-0.05155117,-0.10654706,0.031021716,-0.03330325,0.0053441715,0.05675154,-0.018551385,-0.037281495,0.074829064,-0.02838492,2.7463883e-33,0.014889056,0.005964302,0.033561025,0.005275606,0.04943065,0.0033451666,-0.120244496,-0.0012744798,0.0977826,-0.00055831275,-0.015162785,-0.07113529,0.041504037,0.016992288,-0.028602293,-0.012031654,0.010252248,0.05680774,0.050912276,-0.070175126,-0.018825091,0.11261612,-0.011410808,-0.014065529,-0.02909152,-0.008501676,0.025746746,-0.0034468696,-0.024868535,-0.013574752,0.0020854871,0.01635149,-0.09663388,0.01758232,-0.020235028,-0.010942927,-0.07629623,-0.06574504,0.011873889,0.008071513,-0.04505525,-0.0058732065,-0.030543217,0.033428386,-0.0049354346,-0.07790725,0.05656724,0.03301628,-0.0066449326,0.04236451,0.035954285,-0.023697987,0.05338655,-0.04642473,-0.032738194,0.018720882,0.038378023,0.03039803,0.019905645,0.081050575,0.09351779,0.06178166,0.027173996,-0.008129826,-0.0525621,0.020429965,-0.011543798,-0.12341633,-0.035329383,0.08026374,0.014261316,-0.016465034,0.028673405,-0.0005838611,0.06618501,-0.009778491,-0.07247239,0.083419316,0.008207927,-0.107391074,-0.03292397,-0.0025271114,-0.025285764,0.039168604,-0.023154553,-0.030602243,0.053428836,-0.0530442,0.06373244,0.050033458,0.0396085,0.04322416,0.0043290798,0.02551791,0.029219838,-1.9494014e-33,-0.010895523,-0.111592256,-0.08866373,0.009333676,-0.047666345,0.077255644,0.018191623,-0.012138147,0.021579,-0.025790174,0.12398942,-0.0309171,-0.04984279,-0.02103301,0.07426956,-0.031123996,0.10185451,0.064620174,0.04582821,-0.038635235,0.008739949,0.0228647,-0.049458463,0.06556705,0.10522516,0.02797989,0.051646736,0.0057057366,0.12043405,-0.01064182,0.023954198,0.034803234,0.007176658,-0.027379023,-0.03939071,0.044813674,0.015555275,-0.002805749,-0.040961668,0.015982494,0.044187613,0.046677604,0.06307278,0.095077865,-0.020493213,-0.034955792,-0.056541793,-0.057189763,-0.004108207,-0.020321874,0.052752297,-0.098336205,-0.03764342,-0.07464767,0.06483099,0.050625544,0.025438666,-0.07988701,0.04287216,-0.0488814,-0.032333758,-0.024542594,0.040793445,-0.07972212,0.03155178,0.021859922,-0.028354842,-0.027213234,0.06712034,0.032994665,0.08293674,0.028078059,0.026022283,0.02605939,0.046227142,0.017931862,0.028555999,-0.042050328,-0.007484307,-0.10017677,-0.055786725,-0.002675709,0.037547085,-0.07524646,-0.08193011,-0.03354204,-0.00985495,0.09395311,-0.03183924,0.07335733,0.039088514,-0.0820856,0.026309418,0.06078808,0.08301731,-2.9020676e-08,0.005632628,-0.05823745,0.07214859,0.06730992,-0.06762631,0.02674102,0.036999334,0.011272621,-0.004099745,-0.056819487,-0.020115364,0.06707479,0.10730232,0.0286324,-0.028329104,0.08533942,-0.032654013,0.018164536,-0.023101278,-0.015360389,-0.099590816,0.021524064,-0.06959839,0.00950206,0.046840474,-0.033916313,0.0009768946,0.08119617,-0.07123428,-0.05816092,0.039088897,-0.031218857,-0.018126858,-0.023360632,-0.051365405,-0.024572698,0.089802444,-0.00545848,0.016893985,-0.030857388,-0.038753707,-0.06191954,-0.102643885,0.065835536,0.023075465,-0.030905744,0.0038477257,-0.08195615,-0.04086642,-0.02199973,0.07482955,-0.004482824,0.0518943,-0.059770938,-0.02130721,0.043610193,-0.05819903,-0.08559571,-0.015084851,-0.008061927,0.036343247,0.02494702,0.09515489,-0.04033098 +1.5.1.24,"In the reverse direction, L-lysine can act instead of L-ornithine, but more slowly. Acts on the amino group. cf. EC 1.5.1.16, D-lysopine dehydrogenase.",384,1.0000001,-0.065539435,-0.13768731,0.043101124,-0.05546302,0.10174183,0.051580735,-0.079546064,0.0032781656,0.026490936,0.07520764,0.028886463,0.037501857,-0.019890456,0.06712724,0.027643578,0.08950113,-0.07346635,-0.0003810855,-0.040834714,0.0491869,0.06861459,0.051192604,-0.05568949,-0.0165823,0.036955312,-0.030153818,0.0027745694,0.014815444,-0.019339858,-0.085714824,0.0112747485,-0.023166286,-0.070883125,-0.029826045,-0.06605836,0.085072204,-0.0782138,-0.033090144,0.052609544,0.065181464,0.008959615,-0.046703238,-0.13323985,-0.06801857,-0.027752977,-0.0021817891,-0.06424107,0.036673732,-0.007827334,0.01950862,0.0034143494,-0.035837084,-0.022660809,0.044546355,-0.09984984,0.016850019,-0.0851883,0.07926464,-0.022895655,0.033177245,-0.028358432,0.028368767,0.03273559,0.044525653,0.08779295,-0.035444185,0.0364161,-0.06337316,0.010134034,-0.022927228,0.038143214,-0.07618977,0.0075052446,0.05201658,0.06729926,-0.025876347,-0.013354676,0.055839106,-0.029941134,-0.08887748,0.01919179,-0.01357638,-0.031954017,0.09862315,-0.02866111,-0.06295276,-0.06442107,0.04594022,0.03476045,-0.011303852,0.015170844,-0.06319091,-0.029235657,0.015220551,0.057524063,-0.008887809,0.049189452,0.0034272992,-0.016829763,-0.05955077,-0.03366098,0.0782725,-0.1254843,-0.022529341,-0.03174165,-0.0350587,0.029593075,-0.009109568,-0.06094873,-0.0809952,0.047824726,-0.03673735,0.1380959,0.042220127,-0.057489365,0.013044974,0.009502807,-0.012936667,0.0025358617,-0.058795586,0.002616914,-0.02662407,0.026625866,0.11602168,-0.023009945,0.14711659,-0.06965264,-4.339322e-34,0.064193584,-0.042914465,0.051948924,-0.043032188,0.0012774761,0.016874833,-0.029825516,0.048586283,0.03519831,-0.04021417,-0.01454985,-0.03314232,0.06825617,0.034102697,-0.05358804,-0.009658867,-0.0058616865,-0.015063783,-0.032618638,-0.0011241322,0.013180554,0.052164026,-0.06567076,0.016058357,0.0078008072,0.039473906,0.051426522,0.010277199,-0.024959194,0.0008588588,-0.048877943,-0.11064377,-0.034264907,-0.018326493,0.02063002,0.026145613,0.0047633327,-0.044304494,0.023713931,-0.03176928,-0.039217617,0.049543597,-0.09966806,-0.034022037,0.028628036,0.04950656,-0.055834226,0.05862106,-0.09496944,-0.007536346,0.12411652,-0.05735451,-0.010792669,-0.095862694,-0.05068062,0.017010942,-0.035331123,0.010969002,0.019582674,0.093972065,0.07524968,0.06315069,0.017342642,0.036727194,0.0023393724,-0.033047274,-0.040299937,-0.07469673,-0.012098471,0.0059603304,-0.08552185,-0.019486427,0.07964323,-0.0070619164,0.04695061,-0.03143103,-0.0765234,0.009234451,0.04307563,-0.02043144,0.051837344,-0.050691564,-0.014233232,-0.01937767,0.03362778,-0.062348023,0.061311174,-0.14901711,-0.0050499616,0.008263238,-0.0014265259,-0.05455925,0.019555815,0.015765028,0.023499813,-1.5432162e-33,0.0029838993,-0.0780184,0.020266306,0.03244864,-0.024538359,0.06926665,0.032312572,-0.041677635,0.07573744,0.035986263,0.06944684,-0.033497725,-0.04543035,-0.04821672,0.07562801,0.045444217,-0.010219515,0.046508487,0.0148700625,0.04488185,-0.05089285,0.025499802,0.022992766,0.068543546,0.091509596,0.012099317,-0.01344595,0.13571794,0.051950477,0.01406941,0.005095942,0.022336988,0.0015053839,-0.038537603,0.0053076968,0.09161543,-0.06058605,-0.009090114,0.060683597,-0.081408404,-0.0064631784,0.0012801706,0.08851218,0.012466076,-0.02447505,-0.029887028,-0.05603961,-0.06618061,-0.023206083,-0.05819322,-0.004924244,-0.012171813,0.04081339,0.014074753,0.016214512,0.055207692,-0.006281404,0.020398062,-0.02761189,0.023358613,0.008695697,-0.045123596,0.0174266,0.058004577,-0.03199891,0.037820965,-0.03803797,0.0018293851,0.0734472,-0.07118547,0.07329855,-0.017525854,0.05786603,0.043959327,-0.04274361,-0.018905798,-0.01776492,-0.06796345,-0.009561282,-0.04553502,-0.054322116,0.045481067,-0.023546284,-0.04284903,-0.06041889,-0.015650816,-0.041888516,0.13780232,0.0068417913,0.046859052,0.007909413,-0.06291286,0.014585022,0.013787352,0.15493673,-3.2917594e-08,0.05847173,-0.07017745,0.13002738,0.057861786,0.025329119,-0.02251364,0.02334685,-0.0072237076,-0.004338293,-0.029120293,0.022174694,0.06114694,0.023628162,-0.018730756,0.06803393,0.06055541,-0.01369614,0.057449587,-0.005792364,0.08188215,-0.010578498,-0.027581124,-0.077254586,-0.007895208,-0.0013570986,-0.044348538,-0.015243718,0.023278328,0.047618944,-0.06968209,0.0017895348,0.0024334018,-0.0061439034,-0.024903521,-0.068882704,-0.01949232,-0.04897084,-0.014961365,-0.0028737425,0.021252668,-0.041531526,0.007405221,-0.041757047,0.0219474,-0.00012396004,-0.024427695,0.044889864,-0.04365734,-0.008402132,-0.00022500685,0.034976132,-0.032097813,0.036048222,-0.040983267,-0.02563185,0.07316546,-0.12236515,-0.034967277,-0.0059618205,-0.056170866,-0.027709503,0.07032263,0.14930518,0.0035622006 +1.5.1.25,"The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly.",384,0.99999994,-0.019712873,-0.055831067,-0.007906711,-0.031603176,0.1261791,0.024457784,0.033077307,0.09539223,0.061148424,-0.0053621614,0.06863352,-0.03906768,0.07837614,0.04491445,-0.09676541,0.04648864,-0.012509324,0.031055244,0.028523417,-0.026567673,0.05063402,0.05743485,-0.025687166,0.043806136,-0.022989769,0.005359394,-0.02583616,-0.056223314,-0.03597933,0.0072527053,-0.044586837,0.00402228,0.02702128,0.015809685,-0.019670319,0.05386141,-0.024162011,0.015375158,-0.025101634,-0.020924145,0.018647308,-0.07440163,-0.047362786,-0.031554177,0.0030169361,0.0005867408,0.0506354,0.0038551008,-0.0018954674,0.026139291,-0.014803562,-0.055647045,-0.08160615,0.098743625,0.007676637,0.013092654,-0.09045205,0.030185353,-0.054139085,0.028021602,0.11837262,-0.026434962,-0.021768725,0.00038095794,0.072920874,-0.028423922,-0.010779491,-0.070750296,-0.07093828,-0.08164677,0.032602713,-0.10952911,-0.038956687,-0.03439938,0.018151516,0.012152896,-0.023798846,-0.095637746,0.043679174,-0.057759356,0.020877892,0.016350947,0.024498293,0.045609906,0.063117675,-0.014364558,0.017512653,0.011436833,0.045392927,0.041409224,-0.013940405,0.079981335,-0.011059525,-0.005352503,-0.08012671,-0.012201689,0.049625773,0.11127565,0.03854229,0.077835694,0.02507051,0.07388488,-0.0651929,-0.10396562,-0.09624568,-0.06418446,-0.026241006,0.0020634702,-0.065881714,-0.02640511,-0.046015345,-0.013856848,-0.034704514,-0.021561312,-0.04886108,0.11816885,0.055739842,0.07101009,-0.005945839,-0.009549427,-0.019191552,0.036475405,0.01332511,0.09849586,-0.0062135216,0.056506455,-0.0053795762,-8.911611e-34,-0.014383019,0.0081284,0.019611953,0.034246296,-0.08467658,0.018788598,-0.060918335,0.041642398,0.009014629,-0.045704056,-0.046574555,-0.044676393,0.009221311,0.008545059,0.01919146,-0.107479505,-0.03876487,-0.03591113,0.15019177,0.0007561172,-0.06329433,0.08390102,-0.034652337,0.021085706,0.026744157,-0.07809789,0.008287878,0.006051159,0.0043247463,0.02033281,-0.023272278,0.029678175,-0.04899036,-0.1227853,0.01324742,-0.016564485,-0.049949363,-0.0017327205,0.019136945,0.057816874,-0.03524121,-0.0030549672,0.05835121,-0.029442005,0.027218096,-0.030721676,-0.031836897,0.08240547,-0.012655566,-0.04376799,0.03192973,-0.02866425,0.033443414,-0.0627131,-0.048070315,-0.0101751,-0.03997107,-0.010800757,-0.030414062,0.088739485,-0.021791875,0.05140464,-0.035522334,0.081851736,-0.07330543,0.032082446,-0.08220182,-0.06695314,-0.008058311,0.08231328,-0.015178002,0.0051387204,0.11870195,0.03652352,0.05784337,-0.042864416,-0.035036463,-0.010991993,0.073805615,0.01553201,-0.051161926,0.021186162,-0.07216085,-0.003843126,-0.03621011,-0.044850517,-0.026024042,-0.06234218,-0.03776636,0.04558604,0.024167811,-0.030913167,-0.016681274,0.046599105,0.050293993,-1.1073823e-33,0.019328104,-0.11204508,0.01084721,-0.037871994,-0.004899408,0.022125438,0.0033918875,-0.028682705,0.012440163,0.034814667,0.06273671,0.00531347,-0.006964429,0.037640657,-0.037628897,0.018055564,0.045090098,0.057803348,0.041256525,-0.0092982305,0.0028475279,0.036305353,0.06143168,0.0034619046,0.061103117,0.0391486,-0.017016016,0.093823105,0.08328624,0.11425835,-0.047239896,-0.07432045,0.016394444,-0.046399686,-0.01234124,0.12133249,0.022651473,-0.10013066,-0.020677213,-0.023064809,-0.04086814,0.020477744,-0.0024582637,0.086392306,0.015142027,0.040078998,-0.002915853,0.04242992,0.010730982,-0.09764383,0.025203938,-0.02452777,-0.038658142,-0.057120346,-0.0064204084,0.06428532,-0.027925232,0.024027256,0.023522578,-0.016641652,-0.0060292957,-0.0017440544,-0.02247509,-0.104323216,0.006459823,-0.0011240409,-0.02418453,-0.013923265,0.009732223,-0.002595001,0.08553851,-0.015357374,-0.022904294,-0.022111585,-0.031850062,-0.04660862,0.0388702,0.03305387,-0.01008814,-0.05032529,0.00049624627,-0.01719508,0.02590211,-0.0006328613,-0.05633067,-0.10880748,0.033212136,0.011405415,-0.015473307,0.043739196,0.014192066,0.04047858,-0.048844352,0.12710135,0.06622965,-3.3662225e-08,0.092263006,-0.14111038,0.05915924,-0.09602551,0.0070341807,0.011506124,0.061988436,-0.009054726,0.049386814,-0.107878566,-0.0010683723,0.0628782,0.030740771,0.035877693,0.093401834,0.052665304,-0.04820867,0.007405501,-0.050914846,0.019423647,-0.008778101,-0.026739834,-0.06347537,-0.05111485,-0.11795397,-0.04945771,0.03491971,0.019676708,-0.05151171,-0.053357173,0.042033467,-0.02869002,-0.02217494,-0.015468185,-0.040723126,0.05578248,-0.049922273,-0.036893096,-0.016293898,0.012929165,-0.07877842,-0.0007389539,-0.095869884,0.07321054,0.058844484,-0.045090515,-0.03415372,0.06268315,-0.036950592,0.03751694,0.012414105,-0.041658793,0.020605262,-0.058081325,-0.0138226,-0.0436332,0.058060594,-0.099236116,-0.0029163333,-0.07203757,-0.05500182,0.08237434,0.15992357,0.008808718 +1.5.1.27,"Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions.",384,0.99999994,-0.006929112,0.0172393,-0.0026914836,-2.8843933e-05,0.04083176,0.033204027,-0.02494183,0.03852148,0.01163001,0.012494227,0.03719418,0.0036451053,-0.033371996,-0.01152123,-0.033247553,0.030735964,-0.088424504,0.06352131,0.016178105,-0.06587375,0.01232127,0.005424392,0.047714774,0.05051261,0.017080847,0.036252115,-0.0437164,0.048444442,0.010922138,-0.0777923,0.07983005,0.028458491,-0.042914346,-0.049812563,-0.09090345,0.029090647,-0.06180163,0.0038887064,0.08606599,0.023131715,0.06527029,0.008070602,-0.025081538,0.0032118205,0.010442584,-0.036599968,-0.043608636,0.021730665,0.010514681,-0.021922069,0.061767112,-0.055648524,-0.010835741,0.09248776,0.032512784,-0.057879213,-0.023637345,0.07138346,0.010165892,0.031208636,-0.016762426,0.023541288,-0.0130453035,-0.048173733,-0.022794975,-0.058933396,-0.07929601,-0.014066695,0.0930051,-0.0076706456,0.035069533,-0.04064176,0.020007698,-0.010844346,-0.033741385,0.021029765,-0.06585466,-0.031981003,-0.06188698,-0.0018192227,0.13057667,1.8374121e-05,-0.04685469,0.11919613,0.008831192,-0.049672656,0.008599513,0.024401087,0.059072625,-0.023278398,0.12098995,-2.499285e-06,0.013996276,0.074677475,-0.05989141,0.027191872,0.010741595,-0.07596513,-0.045479044,0.028189389,0.0069388477,0.0015646162,-0.117327064,-0.07251673,-0.066227466,0.017242186,-0.04953466,0.006194097,-0.06450999,0.026969278,0.03387904,-0.05769467,0.015053427,0.06123835,-0.10101174,0.09227741,0.031662825,-0.0075617535,-0.05534745,-0.11494954,-0.020113412,0.015122109,0.0576216,0.009346341,-0.011608408,-0.0028786003,-0.10214325,2.7923029e-33,0.021305952,0.049344294,-0.041949295,0.04161493,-0.0037071623,-0.04630576,0.015178718,-0.009215404,0.03836824,-0.10525596,-0.08503857,0.011922122,0.006502076,0.025343422,-0.08958869,-0.09125841,0.0049273744,0.023731632,-0.031965606,-0.029964902,-0.019423697,0.03478702,-0.084383935,-0.060456716,0.047439456,-0.00438984,-0.027774809,-0.019488312,0.05966681,-0.018522883,-0.0037399852,0.015302937,-0.081537046,0.06328271,0.115366414,0.040872943,-0.0037103018,-0.056395065,-0.016990263,0.01099062,-0.007192923,0.050169874,0.02736308,0.031848688,0.082528874,-0.0011768165,-0.0383994,0.09183112,-0.01093393,0.068462394,0.064700685,0.02091803,0.028070472,0.0052858787,-0.046714634,-0.021120558,-0.027991146,-0.03410767,0.06440978,0.031523697,-0.0118409125,0.010354177,-0.089463465,0.010800307,0.0059401416,-0.011041762,-0.10604133,-0.06118401,-0.029535284,0.08185278,-0.05301693,-0.053950988,-0.012574938,-0.015051214,0.023113603,0.0012560866,0.0058190436,0.07280432,-0.015591267,-0.031958446,-0.010378038,-0.056053262,-0.037120294,-0.040243115,0.0075529497,-0.0022584014,0.011897058,0.026905825,0.0046478803,0.0033653327,0.048787363,0.04377719,-0.062180366,0.017972637,-0.022081012,-1.7015722e-33,0.05835928,-0.063911386,0.023447946,0.03423104,-0.017870631,0.010578819,0.056724064,0.032437805,0.07988319,0.019556152,0.031597115,0.02894646,0.07013175,0.01029921,0.033844285,-0.018157793,0.012805965,0.13660526,-0.014198633,-0.021677328,-0.12107464,0.11887701,-0.0794918,0.03369272,-0.02243631,0.031325724,0.051964138,0.058527123,0.05800175,-0.038299367,0.015966883,-0.09295296,-0.06897433,0.0036807838,0.038886394,0.12482492,0.041839607,-0.01992857,-0.05245229,0.081970945,-0.059158005,-0.021114267,0.026529059,0.061004113,0.05956871,-0.049214073,-0.0681334,0.11636094,0.009734273,-0.05964834,0.07036905,-0.03220571,0.017755149,-0.0032694754,0.031878408,-0.056181695,0.038653087,-0.007645451,-0.008992373,-0.0068682157,0.04057109,-0.034474064,0.007508962,-0.05059546,-0.012810294,0.019703183,0.037598312,0.033037256,0.07399265,-0.0030766267,0.06369031,0.086422525,0.04511469,-0.01988422,-0.0040836744,-0.06030742,-0.060043294,-0.04582978,0.029738052,-0.058153197,0.052735016,0.02246805,0.058256138,-0.059313178,-0.011011674,0.0021916653,-0.030735347,0.09142006,-0.024334705,0.018469391,0.0022604303,-0.044443853,-0.00919116,0.1766149,0.13772073,-3.3563605e-08,-0.0020618634,-0.03556081,0.015347083,0.012597111,-0.011267851,-0.000876345,0.0546549,-0.025510022,0.010614872,-0.09955036,-0.027216652,0.07800925,0.020088878,0.08192113,0.04611512,-0.0098208,0.011819804,0.07919588,-0.05139965,0.030493157,-0.005959488,-0.020994063,-0.07859695,-0.018071633,-0.0037974732,-0.033651825,0.07028033,0.01917306,-0.03170905,-0.029027153,0.09121936,-0.025252827,0.0011208971,-0.0012148931,-0.04263847,0.040940028,-0.00405168,-0.03306109,0.016330319,0.0003249989,-0.00020283872,-0.014535497,-0.047406364,0.006479245,-0.062514454,-0.093986616,-0.035621915,-0.005062572,-0.06739298,0.026326794,0.104828365,0.006213848,-0.0041962317,-0.06614635,-0.115118906,-0.09376086,-0.08271241,-0.008459348,-0.06095404,-0.08077491,-0.007906318,0.023448393,0.19156387,0.030862993 +1.5.1.28,"In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate.",384,0.99999994,-0.033847902,-0.11926958,-0.045012183,-0.058396645,0.05412391,0.073042355,-0.05004509,0.039714318,0.003290941,0.04310764,0.044312198,-0.038974047,-0.1324764,0.04894496,0.006184814,0.09294387,-0.07272778,-7.713387e-06,0.049867995,-0.024831297,0.04074786,0.01289657,-0.09457782,-0.011521175,0.014124261,0.01727173,0.06149324,0.051990718,-0.021410901,-0.032305185,0.0062488876,-0.09861306,0.04159465,-0.009141789,0.006966205,0.08783388,-0.09041116,-0.06138339,0.049126945,0.009819031,0.03497998,0.048146863,-0.023220941,-0.06662315,-0.01984467,-0.021878025,0.0015801811,0.023779565,-0.008565872,0.026789023,-0.013229883,-0.031492572,-0.017469728,0.06822249,-0.017585466,0.029818445,-0.04195145,0.035524346,-0.020861119,0.018353688,0.002723733,0.03652628,0.016124956,-0.09728165,-0.011459386,-0.013613244,0.03156776,-0.08064379,0.009483286,-0.09078633,-0.05328228,-0.081972994,0.024892109,-0.009704891,-0.007843095,-0.026365941,-0.045545008,0.062354844,0.0062398487,-0.07764773,0.004607919,-0.013930832,-0.0017271863,0.03640184,0.016878424,0.006262201,-0.07249841,0.053775296,0.10224217,0.023259327,-0.0052753016,0.0107108895,0.009303874,-0.047193985,0.006670851,0.022056883,0.021333106,0.042730607,0.034191888,-0.0008867026,-0.009315781,0.05394549,-0.056596693,-0.11868349,-0.05275622,0.021328708,0.006609043,-0.019800546,-0.005199454,0.052838728,-0.05182986,0.018210363,0.1171852,0.011084236,-0.002605738,0.066656895,0.0029892065,-0.022582687,0.03364078,-0.034288727,0.027547529,-0.031921647,0.16222261,0.110944115,-0.015570339,0.0774706,-0.113281436,5.4241185e-33,0.06644775,-0.027530057,0.061587162,0.029195659,-0.010117827,-0.017857622,-0.05001224,0.09763349,0.041638475,-0.05245742,-0.07419124,-0.031540945,0.10178223,0.017985588,-0.056874994,-0.031835414,-0.03817252,-0.01140492,0.049979765,0.065779686,0.026333932,0.069087945,-0.034536045,0.075128384,-0.0044441395,0.044061612,-0.01836693,-0.041290265,0.009910268,-0.031960044,-0.015753772,-0.111090906,-0.0631146,-0.03339024,0.028925056,0.008736523,-0.081856124,0.032339923,0.02733159,0.05239409,0.0070429686,-0.0609151,-0.011122764,0.014397294,0.09193758,0.015356652,-0.033622332,0.051964264,-0.036638737,-0.0061858124,0.05450536,-0.05945419,0.0152959125,-0.049475934,-0.10314197,0.05386836,-0.060920276,0.019310618,0.058431044,0.07698107,0.01163185,0.033683825,0.017711056,-0.029626723,-0.0512137,-0.053155325,-0.1182354,-0.069621205,0.0124102,0.05166475,-0.056561984,-0.050162673,0.060889643,0.04969276,0.01994975,-0.041504625,-0.053623952,0.031078648,0.056935232,-0.058530334,-0.019076824,0.06289756,0.0150091,-0.057894733,-0.026528599,-0.07424237,-0.024308464,-0.1295394,-0.02489731,-0.0018458277,-0.026884653,-0.078444384,-0.057101507,0.01412727,0.073370606,-6.221017e-33,0.08639087,-0.0945445,-0.02642382,-0.0327891,-0.042776633,0.06806466,0.08134716,-0.029894894,0.06651614,-0.027001647,0.063207105,0.004576453,0.021848544,-0.021231147,0.03638184,0.0307036,-0.007204486,0.09553222,0.022361761,-0.04603069,0.024860479,0.11139456,0.024160782,-0.031759396,0.044094644,0.010616924,0.0013389022,0.10459719,0.11674471,0.06601719,0.0175762,0.04300206,-0.0036805184,-0.04515306,-0.065265626,0.05433004,-0.09762808,-0.07784965,-0.0039129667,0.05379108,0.009879639,0.0005625054,0.017400468,0.08072602,-0.011811377,0.045659244,-0.09085797,-0.028988035,-0.039122105,-0.05297803,0.012329526,-0.042275615,-0.04854085,0.005588,0.029714439,0.10192931,0.017614286,-0.0089239385,0.0056620655,0.045313947,-0.027015002,-0.07787212,0.08161972,-0.02798094,-0.05335629,-0.030023841,0.044205975,0.017101686,0.03413524,-0.024792254,0.057581406,0.015579865,0.026698014,0.06728,0.011612494,-0.02770315,-0.036931794,-0.028616995,-0.004398737,-0.11734568,-0.066882566,-0.04258226,-0.009622425,-0.013407988,0.0057880725,-0.060923364,0.012158406,0.055439472,-0.0031700428,0.057524443,-0.03252701,0.007957156,0.008111763,0.093231626,0.053724155,-5.5524552e-08,0.03370247,-0.02904375,0.07358053,0.016286425,-0.001621368,0.00045606456,0.004269984,-0.019973684,-0.012978451,-0.09232395,0.010620948,0.04437175,-0.04147555,0.04633233,0.020080753,0.06423885,-0.011188844,0.048123505,-0.052078485,0.024454067,-0.051229056,-0.00035385095,-0.12500574,0.0044060647,0.011075857,-0.037771784,-0.006829752,0.042075954,-0.013109609,0.0035387725,0.0047140955,0.008847951,0.062071946,-0.11208126,-0.012111254,0.039732717,-0.02946007,-0.023548316,-0.028389193,-0.011820296,0.04100276,-0.046758283,-0.093343444,0.004565847,0.061185613,-0.0031992667,-0.043524258,0.02198786,-0.044571992,0.053611733,0.06660714,-0.014007678,0.01983342,-0.008809331,-0.06118411,0.03933978,-0.05168867,-0.041655816,0.050168257,-0.042326648,-0.0312535,0.10566653,0.14384021,0.025088545 +1.5.1.29,"Catalyses the reduction of soluble flavins by reduced pyridine nucleotides. Highest activity with riboflavin. When NADH is used as acceptor, the enzyme can also utilize FMN and FAD as substrates, with lower activity than riboflavin. When NADPH is used as acceptor, the enzyme has a very low activity with FMN and no activity with FAD [1].",384,1.0,-0.014754259,-0.059909936,-0.10055394,0.0030800814,0.082570545,0.03967254,-0.027043596,0.0676975,0.04416021,-0.0018762709,-0.021028366,0.107149005,-0.1327317,0.119510695,-0.012420306,0.013385405,-0.07483401,0.03029677,0.008616308,-0.0081325695,-0.025117436,-0.027082235,0.058759026,-0.013670232,-0.027190875,-0.017206283,0.009483726,-0.042940773,0.043529138,-0.039507303,0.055674184,0.029474104,0.07711689,-0.03220231,-0.054632578,0.07517368,0.005906684,-0.024723941,-0.01972122,-0.011050476,-0.016852858,-0.04207577,0.04167602,-0.056684487,-0.0070165037,-0.019807903,0.014590435,0.10128821,-0.008911121,0.04918978,-0.034098778,0.032419384,-0.07029704,0.0024977517,0.028443426,0.013371622,-0.035223573,-0.090796754,-0.028151136,-0.032647967,-0.005973111,0.009511542,-0.07218447,0.0013528792,0.071410954,-0.059732895,0.051967543,-0.05690665,0.006849356,0.010606208,0.011654889,-0.002656799,-0.03051262,-0.044074055,0.014228871,0.04470099,-0.04949086,-0.027693521,0.042818055,0.033593114,0.05376605,-0.022692846,0.010005419,0.072189435,0.0326536,-0.0053891283,-0.120662995,0.02438713,0.005230857,0.06795728,0.054219175,0.058836494,0.03605936,-0.034397777,-0.09373752,0.062825575,0.054831762,0.038659174,-0.026820485,0.03020284,-0.012278113,0.04100161,-0.054507006,-0.059541695,-0.070290245,0.0174054,0.030694596,0.059279807,-0.035705864,-0.025735857,-0.011454486,0.009960013,0.010877538,-0.03859581,-0.101213805,0.103173524,0.022070086,-0.066866614,-0.08299338,0.02821766,-0.06768768,0.032152295,0.09435956,0.11487895,0.0041183704,-0.003759601,-0.090949155,4.859347e-33,0.044673715,0.017175788,-0.015155154,-0.060406454,0.01076493,0.00743774,-0.06212477,0.03442758,0.011990381,-0.035789303,-0.056366883,-0.02149396,0.078036405,-0.029525172,0.033776358,-0.09195373,0.01472122,-0.040136546,0.0180557,-0.06605566,0.09955183,0.03372453,0.023549493,0.09008485,0.06704834,0.05132888,-0.04115957,0.07190964,-0.010059335,-0.012285399,0.085813835,-0.10282138,-0.06140392,0.04503574,0.018455975,0.009777846,-0.14268275,-0.04075792,-0.035968233,0.068024695,0.0025758133,-0.011593821,-0.067868024,0.020018464,0.057642803,-0.074994214,-0.01891723,0.079655305,-0.00912164,0.07739779,0.11409478,-0.0075633815,-0.009604155,-0.031099398,-0.015216933,0.018451698,-0.00109777,-0.043036513,-0.0022498488,0.055556003,0.030417792,-0.031693276,-0.014266228,0.0282005,-0.06445534,-0.029161362,0.02276248,-0.10498681,0.023623323,0.05003223,0.0141827855,0.0015463042,0.07463292,0.020491334,0.07248964,-0.009087972,0.020413006,-0.019992819,0.024549643,-0.021498645,-0.027318688,0.01763402,-0.003966424,0.015666636,-0.06538046,0.014091889,-0.029473413,-0.089082316,0.022199027,-0.012091492,-0.0038299316,-0.10726344,-0.030501528,-0.050863784,0.09252731,-4.6267987e-33,0.02450136,-0.07503186,0.023017071,-0.044212505,-0.08820025,0.061314557,0.0399084,-0.12137703,0.060119946,-0.05567437,0.010251446,-0.0046465867,0.010985765,-0.0093397945,0.03231542,0.029033743,0.0039130254,0.008521699,-0.0022069416,0.038166523,-0.06578703,0.09831525,0.03899558,0.033087276,0.027157076,-0.004092319,-0.021253338,-0.020834083,0.08670782,0.09714586,-0.052704632,0.020856496,-0.037495676,-0.03858359,0.010398974,0.046903607,-0.05035481,0.053280063,-0.054000657,0.025888378,0.018924754,0.05776551,-0.033975806,0.02387539,-0.0038775452,0.0715274,-0.09114866,-0.06075396,0.02264607,-0.073241495,0.0708526,0.018637046,-0.0034996024,0.030650718,0.09302916,0.027797429,0.061079185,-0.03590908,0.015026985,-0.015714828,-0.0024020877,-0.09888336,0.008875488,-0.029141372,0.085137054,0.032149773,0.011592014,0.10989471,-0.0018475862,-0.056625303,0.050075684,0.006308348,0.09926356,0.10331738,-0.0032768091,0.026000077,0.0059449766,0.0033400508,-0.023151461,-0.022125188,-0.01354719,0.030885883,-0.03138952,-0.10788181,-0.045491077,-0.038636714,0.026689066,0.013108506,0.016007634,0.060202923,0.027311414,0.042398535,0.077685274,-0.008514783,0.05946166,-3.5876017e-08,-0.009417732,-0.050273493,-0.018700108,-0.05185878,0.012474839,0.061379123,-0.005274955,-0.024312397,-0.020218391,-0.051858988,-0.06276355,0.07317915,0.04112213,-0.022916725,0.104209125,-0.036640715,-0.061532147,-0.011695488,-0.07433772,-0.043064423,-0.07239047,0.101786464,-0.10789309,-0.01360078,-0.023494774,-0.010409963,0.005730035,-0.042067174,0.020013366,-0.018508272,0.026433704,0.034889415,0.05745709,-0.022549827,-0.0910989,0.0024067753,0.089712426,-0.032523468,-0.086274356,0.0765142,-0.061961528,-0.031475727,-0.05426598,-0.020215167,-0.057323605,-0.01842949,0.00013241754,0.024058167,-0.037250154,0.06081776,0.06527662,0.017199881,-0.025266487,-0.053663015,-0.092367366,-0.035642337,-0.033851437,-0.055458445,-0.057216555,-0.09845133,0.010960234,-0.011618362,0.095468946,0.01581346 +1.5.1.30,"The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.",384,0.99999994,0.0024575586,0.0134766875,-0.073373884,0.029757572,0.07658308,0.04940588,-0.12718697,0.10287453,0.067548655,-0.0047797696,-0.034258418,0.08780835,-0.07584794,0.07827402,-0.058268413,0.019742187,-0.0109989485,0.016174555,-0.03707674,-0.050999366,0.024628857,-0.018301412,0.04192136,0.007675057,0.06149713,-0.05109232,-0.037361868,-0.013386062,0.0070244167,-0.019999094,-0.0062453216,0.055597685,0.022918725,-0.023996994,-0.07451009,0.08875622,0.02069569,0.005932169,-0.03765368,0.023052346,-0.039289307,0.003977532,-0.06866511,-0.038315065,-0.010359411,-0.013299335,-0.037291087,0.05807321,0.031243594,0.0795865,-0.096121,-0.0055529075,-0.058319606,-0.0049116444,0.08871198,0.026036348,0.006404575,-0.054542936,-0.07020239,0.011496692,-0.027932355,-0.07062587,-0.045042854,0.032808304,0.096113086,-0.05846931,0.054769296,-0.05499953,-0.025035294,-0.06103586,-0.023016158,-0.02013344,-0.02471976,-0.031096734,-0.009726563,-0.0012009611,-0.069762155,-0.06489457,0.03639005,0.032252017,0.077105924,0.050383367,-0.017810106,0.054680254,0.05259712,0.010528994,-0.006071736,-0.036202326,-0.03797852,0.029091656,0.054803368,0.020359606,0.008883292,-0.035116415,-0.10502422,0.022640416,0.0507195,0.043937333,-0.055586968,-0.003373887,0.030791875,0.06581562,-0.01737537,-0.09198672,-0.08307614,0.021186044,-2.6283606e-05,0.10266828,-0.026730206,0.01403249,0.05338312,0.033233754,-0.008374602,-0.010648624,-0.075523116,0.12406385,0.01831457,-0.011334714,-0.08686845,0.052012417,-0.043560416,0.03363742,0.054441676,0.09252577,0.0089184,0.0057622627,-0.085854046,5.160949e-34,0.06621755,0.019770978,-0.059138715,-0.062301174,0.021712553,-0.011224148,-0.101854146,0.04180651,0.07303912,-0.01327485,-0.052758202,-0.043241475,0.055240557,-0.07342484,0.04561881,-0.060912143,-0.021722961,-0.037901256,-0.009816754,0.009532455,0.092555165,0.03461958,0.015517547,0.07252339,0.044747543,0.002750523,-0.027330888,0.06400678,-0.052884907,-0.008358079,0.018130261,-0.08298503,-0.0872822,-0.008152171,0.038685765,0.007719241,-0.09750974,-0.07315701,-0.027598217,0.05505112,-0.03785363,0.008507289,-0.031252675,-0.028100772,0.07524008,-0.11032736,-0.026840908,0.06980023,-0.002390656,0.07862308,0.08523194,-0.03319194,0.06548144,-0.021129997,-0.01022617,0.019308504,-0.007071519,-0.061903555,0.024571043,0.078897804,-0.001631775,-0.046878394,-0.015773298,0.078898504,-0.04853183,-0.019026438,-0.05219957,-0.08350942,0.0066269133,0.08066652,0.009152778,0.009772536,0.100087024,0.030368293,0.010953037,-0.023429623,0.001623665,0.021229163,0.057054807,-0.028838264,0.015735362,0.013612777,-0.08546845,-0.029122548,-0.014120989,0.008297142,0.05243599,-0.06813514,0.0055991416,-0.047317848,0.08278829,-0.06279786,-0.02588547,-0.06474762,0.07107103,-1.7383569e-33,0.08977069,-0.08349006,0.043637823,-0.06388654,-0.047454573,0.09907289,0.02195823,-0.07956532,-0.026538342,-0.081425495,0.006891237,0.017757524,-0.0011558966,-0.012133044,0.025265133,0.01023,-0.004121641,-0.047612187,-0.0355223,0.022095395,-0.054552782,0.12955308,0.03794292,0.014011337,0.044559702,-0.033185523,-0.07605974,0.02785755,0.08074051,0.066972785,-0.021386446,-0.003467667,-0.08420181,-0.053992286,0.04090798,0.10220024,-0.06167651,0.02719607,-0.007227467,0.052712362,-0.024541024,0.04902368,-0.032618795,0.027251747,0.03269144,0.06650783,-0.11657714,-0.086917624,0.04996727,-0.08383764,0.085531056,0.027032763,-0.007744878,0.0011443507,0.032610755,-0.016760727,0.022919947,-0.017489072,0.0135616865,0.02343885,-0.0069625215,-0.051451895,0.014518054,0.020726101,-0.010889004,0.022643879,0.01209671,0.035749204,0.06674216,-0.01339027,0.031051207,0.012332291,0.078121915,0.070229314,0.0014146216,-0.012747219,-0.035404712,0.04743642,-0.08158195,-0.012809194,-0.0109002255,0.032222044,-0.09242251,-0.07834412,-0.07673464,-0.019098394,0.034210883,0.034700613,-0.020162085,0.03747798,0.017356077,0.06307172,0.009789949,-0.013371581,0.05544534,-2.5322235e-08,0.02999059,-0.05744312,0.0737344,-0.05164683,0.03221129,-0.0024978598,0.030049803,-0.0020036965,-0.0036078298,-0.030155772,-0.04220028,0.15709461,0.0038967843,0.02647443,0.07708329,-0.0010541903,-0.04440109,-0.022818174,-0.023220174,-0.004526261,-0.04050424,0.055232506,-0.108291045,0.030743517,-0.044055495,-0.039921056,0.019908113,-0.020083671,0.029542191,-0.03628275,0.028026193,0.06461628,0.062327962,-0.019291477,-0.10055538,0.031196836,0.0696452,0.022230692,-0.05302033,0.07622459,-0.045748882,-0.06738364,-0.050486542,0.0008536193,-0.03302325,-0.048244994,0.07288557,-0.008293553,-0.020774372,0.03026105,0.071086906,0.033447895,-0.033944264,-0.062335268,-0.063886285,0.0062086377,-0.011209086,-0.07406024,0.0071000834,-0.07278574,0.002376415,-0.023204738,0.11484793,-0.03957613 +1.5.1.31,"Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC 1.3.3.8 tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine.",384,1.0,-0.107427575,-0.022348093,-0.15745,-0.010323249,-0.00021714321,0.08296747,-0.074659504,-0.00901813,0.07908346,0.024074055,0.050515804,-0.05137547,-0.002792345,0.0011554417,-0.043348063,0.04537914,-0.090406634,0.08159404,-0.06633193,-0.016458016,0.040320892,0.063397564,0.01792733,0.017160138,0.038405083,0.038380027,-0.033302143,-0.0033537205,0.068041526,-0.050198026,0.07741587,0.049983464,-0.010634149,0.0013809098,-0.0108974455,0.07762263,-0.115362264,-0.044424877,0.07371232,0.06622381,-0.011741549,0.01983809,-0.020950058,0.0067758146,-0.1275159,-0.08171491,0.0018004761,0.055172622,0.059956018,0.011618182,-0.01160285,-0.01984423,-0.037411854,-0.007226179,0.038678817,0.0052181827,-0.013294182,0.03976972,0.011872503,0.030462999,0.09874971,-0.031322658,0.050150733,0.021160567,-0.056216326,0.0094021065,-0.057066984,-0.07779198,0.049994484,-0.12896729,-0.04394936,-0.035246905,-0.00047763687,0.060990386,0.0038401103,0.071463235,-0.02225654,-0.026168557,-0.056871623,-0.044367414,0.016752545,0.02628372,-0.02658055,0.036100037,0.013735296,0.009885172,0.031000106,0.019600453,0.04921219,0.016148746,0.11075732,0.021813728,0.029181572,-0.020574152,-0.013250895,0.018676156,0.11605942,0.03975536,-0.026159598,-0.06672082,0.025642343,0.042184856,-0.12597455,-0.049112648,-0.08972111,-0.03892494,-0.006319334,-0.041803498,-0.06235087,0.00671476,0.050034206,-0.032090217,0.027969565,-0.013558403,-0.042729884,0.069903724,0.07446519,-0.05718353,-0.042307746,-0.00238231,-0.029771902,-0.031249432,0.014403651,0.006535548,-0.022414763,0.017392304,0.0068212226,3.2691034e-33,0.04908688,0.05131668,-0.017202746,0.015128042,0.103268355,-0.04504868,-0.0744402,-0.028142096,0.011293775,-0.051533516,-0.10076786,0.02675566,-0.011094795,-0.04029474,-0.06530812,0.025818624,-0.060617562,-0.09601812,0.007544887,0.007692967,0.007852,0.081500806,-0.053595096,0.041862234,-0.05182338,0.06386034,0.075683296,-0.020957785,0.06690557,-0.041359056,-0.03334766,-0.13420957,-0.11308825,-0.045628235,-0.014507431,-0.02704205,0.020607054,0.015912574,-0.0400854,0.08528606,0.050738554,0.03337785,-0.0062960163,0.00834951,0.07221339,-0.033991396,0.018898278,0.084359996,0.07351754,0.017633162,0.0420822,0.010490557,0.092159,0.030868346,-0.051370423,-0.020156667,-0.040066756,0.012430122,0.020403095,0.08643739,0.011291502,-0.007935299,0.061128795,-0.018450804,-0.02065042,-0.017520556,-0.06962135,-0.072164536,0.032290015,-0.007366413,-0.025138907,0.00021491821,0.046369784,0.010261265,0.024071088,0.040688097,-0.045019034,-0.027444957,-0.008867492,-0.038712524,-0.046757795,0.019841943,0.07810627,0.06179304,-0.082380086,-0.0669007,-0.032535862,-0.044390608,-0.09457737,0.018146062,-0.013454002,0.025027422,-0.016039973,-0.017692044,0.0073810755,-4.2859905e-33,0.114182524,-0.059324417,0.04363058,-0.074520424,0.018863399,0.0503292,-0.00065145135,-0.0054509793,0.035280164,-0.01967471,0.07047926,0.010962609,0.068016775,0.00612637,-0.016988501,-0.0351546,0.029277965,0.12486323,-0.037185837,-0.013562314,-0.10068107,0.056347255,-0.018927837,0.028493911,0.02962272,0.06097227,0.0071351617,0.02674436,-0.011645848,0.07820568,0.10011273,-0.011827262,-0.038022157,0.052096985,-0.03191715,0.07294068,0.0012859241,-0.018717678,-0.023805274,0.052552428,0.0055008507,-0.025793733,0.013943607,0.036159124,0.029650835,-0.022781616,-0.045676082,-0.0049715145,-0.039448526,-0.034467068,0.07670871,0.02225912,-0.03909686,0.06117933,0.06307037,0.058550883,0.021838905,0.009685169,0.05429269,0.00515516,-0.0010361299,-0.050648984,0.014694708,-0.05220219,-0.02779643,0.036552753,-0.06599323,0.046288237,0.11630891,-0.027218405,0.08976962,0.032080177,-0.016668022,0.035016853,-0.005864705,0.028533516,0.014541762,-0.07295234,0.019933186,-0.07770757,-0.10953771,-0.0030961155,-0.014206825,-0.058005273,0.018142711,0.050413944,0.032567192,0.04043013,0.05910004,0.022076022,-0.006304102,-0.09076645,-0.14206441,0.07071645,0.07787256,-3.4411435e-08,-0.010602095,-0.03850948,0.022359146,0.024445772,-0.0019098566,0.040019784,0.056285433,-0.008480496,-0.005721517,-0.07735857,0.034711454,-0.024951166,0.009967674,0.100760855,0.06790738,0.078577794,-0.067288175,0.03028059,-0.023568824,-0.03310573,-0.06569893,-0.036835216,-0.061800323,-0.026754674,-0.04634941,-0.07661964,-0.015168475,0.008728272,-0.011387213,-0.021529507,0.074139014,-0.024205502,-0.009605182,-0.053938728,-0.033887118,0.006894437,0.0045667584,0.03439248,0.018669901,-0.0060643577,-0.060613204,-0.04982614,-0.09037082,0.024684062,-0.052754343,-0.040885687,-0.023328867,0.08070936,0.0010276373,-0.016785795,0.08985691,0.008849314,0.004806288,-0.06509028,-0.09759142,-0.034759298,-0.06820473,-0.0016591375,-0.00402953,-0.09173997,-0.010639996,0.0033736876,0.13111962,-0.010082034 +1.5.1.32,"The enzyme, characterized from the plant Rauvolfia serpentina, participates in the ajmaline biosynthesis pathway.",384,1.0,-0.06785839,0.006624719,-0.12818627,0.03462022,0.046974808,0.06396866,-0.122912064,-0.024989916,0.0068176044,-0.036557622,0.032835852,-0.0322771,0.016557096,-0.07457663,-0.09506103,0.06351664,-0.030157544,0.0817306,-0.062627934,-0.066550635,0.10294626,0.03144499,-0.0038044876,-0.036819592,0.04572614,0.01043281,-0.035210494,-0.038559664,0.024019334,-0.02667747,-0.024408678,-0.015336516,0.026700264,-0.046007745,0.027363008,0.05134331,-0.0660052,-0.04805147,0.07558469,0.04419579,0.051331714,0.02753337,-0.044579048,-0.02983668,-0.059647124,-0.049592976,0.03776737,-0.03938839,0.040605165,-0.029576,-0.058771554,0.0084128305,-0.06319678,-0.063197255,-0.04791071,-0.036495924,-0.0048781643,-0.027873566,-0.008835707,0.03867579,0.09716806,0.018094191,-0.03035853,0.04920309,-0.01883064,-0.10194077,-0.035894,0.002152627,0.07190176,-0.076821454,-0.04235869,-0.0330763,-0.0035705373,0.010325438,-0.0223827,0.05363653,0.057266936,0.015525078,0.0031659666,-0.0036616516,0.0010525546,0.0071417103,0.055883296,0.01400381,0.07870329,0.036453273,0.01321892,0.079285115,0.023559606,0.07925183,0.061704356,-0.029734723,-0.0047707804,-0.052910045,-0.0011700781,0.049123578,0.049888488,-0.06314336,-0.016566679,-0.0055086734,-0.021136235,0.014209625,0.03328207,0.023360366,-0.00978747,-0.007465044,-0.063276626,0.022771321,-0.0024894916,0.008329441,0.006734358,-0.03224161,0.019599361,0.05306152,0.01832728,0.082751244,-0.024352292,-0.047120273,0.000762555,-0.016914159,-0.014545754,-0.028612208,-0.004439478,0.0608677,0.032576475,0.015114469,-0.13570364,5.887384e-34,0.030427799,0.013105881,-0.06724511,-0.039035976,0.01687034,-0.01708276,-0.075210154,0.024690123,-0.022222728,0.016733194,-0.093752764,-0.055350594,0.03733839,0.0011167447,-0.06391288,-0.023266507,-0.018058019,-0.065122075,0.012091388,-0.044724666,-0.007725182,0.031554278,-0.05048868,0.054886587,-0.021845425,0.012293901,-0.016342118,-0.034349266,-0.0056464286,0.0007069035,0.018017605,-0.09209315,-0.058948044,0.046263322,0.03519927,0.019770814,0.025941169,-0.09270558,-0.039339412,0.03499933,-0.038023252,0.060005266,0.0126129,0.05664855,0.056990594,0.0056579355,-0.057089545,0.084912434,0.067512505,0.058435336,-0.055289544,0.035579555,0.20282619,-0.037224364,-0.08150755,0.007446338,-0.029083036,0.010711804,0.0023559432,0.041215196,-0.057158787,-0.0045475895,-0.048984583,0.07558807,0.035223387,0.055672284,-0.070671275,-0.08361215,0.08583539,0.058194995,-0.051707383,0.026420066,0.021014296,0.022848872,0.08114076,-0.0027643284,-0.0074608233,0.0020755718,-0.048934963,0.014859297,0.0006065991,0.0043061,0.020499023,-0.02777357,0.032129012,0.020843465,-0.029337857,-0.055429853,0.048494246,0.009463262,0.08618805,0.019152086,-0.08831581,0.062811434,0.043556623,-9.057249e-34,0.06695538,-0.060209084,0.050661385,-0.025827166,-0.06306671,0.060058955,-0.05758881,0.035836108,-0.00500907,-0.032397166,0.04567443,-0.00921286,0.04211206,-0.014260241,0.006345914,-0.043378826,0.054611433,0.06771835,0.007302067,0.058144797,-0.094563246,0.121697545,-0.018902216,-0.07680286,0.067243606,-0.06393516,0.0010413821,0.050267447,-0.03982819,0.026319435,0.026119621,0.032720767,-0.032226473,-0.034184974,-0.0179629,0.043968387,-0.07460936,0.021702552,0.009774922,0.12506393,0.053777635,0.018046856,-0.0215951,0.061489023,0.033750534,0.041137006,-0.022429371,0.10018917,-0.016062016,-0.09612287,0.0037841194,-0.029171143,0.06669263,0.02952565,0.0803496,0.046597958,0.0582362,0.01243174,-0.028548244,0.014780849,0.038383897,-0.04480525,0.026488742,-0.032148596,0.019545378,0.12684618,0.03269041,0.053933132,0.022854032,0.033724714,0.071120664,0.024538945,0.032005522,0.08230153,0.013407892,-0.047546264,-0.08082946,-0.051657934,-0.086590044,-0.02964595,0.0110787125,0.059517704,0.015338739,-0.13877544,0.0017067614,-0.019933956,0.006153245,0.13179444,0.037896805,-0.009180225,-0.013826945,-0.019496908,-0.0776516,0.028361108,0.09326831,-2.3183757e-08,-0.03612491,-0.020966193,0.028298449,-0.06004609,0.012504527,0.06485837,0.038694896,-0.012079149,-0.0010223738,0.018977601,-0.01657283,0.07144747,-0.03698367,-0.0036579445,-0.015569253,0.043052103,0.009767797,0.058237426,0.020892797,0.032316916,-0.032182395,-0.00949498,-0.06212467,0.015153382,-0.00078897324,-0.11164511,-0.024127763,0.03365194,0.02897968,-0.05235016,0.025238484,0.020225195,0.077201046,-0.08074537,-0.16688317,0.013137441,-0.022955533,-0.051948622,0.055899948,-0.060752947,0.05321109,-0.024993017,-0.0007754437,-0.011180244,-0.041192874,0.02253793,0.04712509,-0.012472409,0.021950142,-0.086665615,0.021889474,-0.015618585,0.03913509,-0.07803598,-0.036325388,-0.0895718,-0.014352238,-0.02435048,-0.038990874,-0.027358484,-0.04005245,0.01263067,0.15973845,-0.12635511 +1.5.1.33,"The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH.",384,1.0,-0.020543797,-0.03142984,-0.038948264,-0.092891015,0.081468776,-0.0024753765,-0.039242823,0.07073382,0.012564689,0.059697025,0.030891767,0.014947635,-0.11105221,0.01829575,-0.05706043,0.012104906,-0.096264854,-0.019951833,0.024727153,-0.019735243,0.010891739,-0.047021247,-0.0047634495,0.0032842234,-0.010798533,0.004703371,0.08684168,-0.016538756,-0.09661869,-0.02449791,-0.087353624,-0.051657658,0.026685413,-0.05736626,-0.024575273,0.08562107,-0.011537739,-0.009886476,0.024922756,-0.006234037,0.00058196665,-0.02542452,-0.07542206,-0.021149248,-0.008958238,-0.048463613,0.031621043,0.080232434,0.0006376055,0.043724738,-0.014757263,0.022027863,0.009537049,0.07129837,0.016309606,-0.028753264,-0.052100137,0.043488216,-0.031990964,0.055597983,0.0213708,-0.010388619,-0.054135922,-0.08635525,0.036331777,-0.07280804,0.054882824,-0.01895666,0.0045942967,-0.061882153,-0.03685552,0.005495017,0.04493342,0.022596564,-0.026383521,0.077551946,-0.011320391,0.0018827715,-0.0076177767,0.03040366,0.048487734,0.04853836,-0.03322082,0.0311122,0.07779508,-0.03527914,-0.04476136,0.041295037,0.039399028,-0.008906355,0.09314914,-0.003575931,-0.021586299,-0.025719507,-0.07417287,0.026518907,-0.019463552,0.006149095,0.03828086,-0.028206144,0.026630705,0.06768018,-0.1024582,-0.073965356,-0.10039516,0.040559117,0.0050383112,0.098519795,-0.017729424,0.016533162,-0.029886331,-0.0086758705,0.02162449,0.026832642,-0.06138317,0.11905078,-0.011305878,-0.08553196,-0.03648045,0.023790115,0.007332588,0.010493904,0.108818755,0.09292536,0.0329488,0.0266387,-0.07222718,4.92819e-33,0.023298431,0.10989614,0.0061239135,0.027573107,0.043015674,0.053614706,-0.07338973,0.09197799,-0.05825089,-0.05985087,-0.04056762,-0.042778093,0.08045648,-0.06592591,-0.0043238597,-0.04025829,0.026815658,-0.012810514,-0.0059921364,-0.0011165643,0.0415577,0.065811686,-0.05464914,-0.003637874,0.04871174,0.01646575,-0.061271843,0.014608205,0.0050136275,-0.019924795,-0.02355753,-0.10299224,-0.053149015,0.049216606,0.012366573,-0.031188196,-0.052882373,-0.055712327,-0.020368738,0.012851181,-0.05091585,0.02512372,0.011504514,-0.035810787,0.065136924,-0.076429725,0.03322471,0.008863114,0.00795078,-0.0019631987,0.081082724,-0.009119685,0.08955371,-0.062294144,-0.02771666,0.007826288,-0.044681694,-0.0012182825,0.08981795,0.08904948,0.099162266,0.02683632,-0.054107804,0.008068188,-0.055721033,0.0196944,-0.081182696,-0.025081497,0.021370482,0.07924105,-0.042891923,0.028421717,0.070725374,0.0066161067,0.061486352,0.0043314663,-0.05226268,0.020701375,0.005680601,-0.05779796,-0.020960217,0.009552317,0.030063022,0.021075288,-0.018685965,0.06009976,-0.031941634,-0.0092616035,-0.018687544,-0.04075723,0.08114745,-0.02505372,-0.110442854,-0.07489095,0.037392765,-4.4721473e-33,0.06392911,-0.062366344,-0.024356887,-0.12785642,0.003536032,0.07249353,0.058037832,-0.04202631,0.06223039,-0.13420619,0.0281756,-0.07044628,-0.009341611,-0.039016176,-0.0016537609,0.04404493,-0.056330793,0.006732298,0.009504228,-0.04149868,-0.08494943,0.064322926,0.028546825,0.038216732,-0.016234942,-0.02327645,0.036729336,0.11233709,0.12296837,0.037894063,-0.012252419,-0.006254846,-0.045502692,0.009820099,0.016674012,0.0921601,-0.12689215,0.008146445,0.012759058,0.09230194,-0.0049672816,-0.019708192,-0.032314673,-0.027563533,-0.010117074,0.057368003,-0.09791772,0.04079799,0.046877097,-0.059202414,0.07722233,0.009322536,-0.023205645,0.020661661,0.06886038,0.037311245,0.04027166,-0.034650076,0.013732927,0.043480095,-0.0065212175,-0.07229412,0.026711084,0.010987373,0.07232747,-0.031386495,-0.037384514,0.14106637,0.05156759,0.034594946,0.072893396,-0.0031543116,0.02869448,0.036015105,0.012189881,-0.00241834,-0.02048611,-0.019554654,0.023609716,-0.005490526,-0.008207923,-0.0018127227,-0.012322439,-0.046801563,-0.03261658,0.0565525,0.008554272,0.015003985,-0.10178546,0.06653039,0.067593336,-0.038770836,0.025763417,0.073732756,0.017580228,-4.7132186e-08,0.13503478,-0.063440785,0.025231801,-0.042060748,-0.009043222,0.019172769,0.044622894,0.06380886,-0.011700264,-0.0328892,-0.058197137,-0.0079451725,0.06236321,0.0302014,0.02985447,0.016055282,0.00455237,0.019708518,-0.056672372,-0.015583649,-0.045639202,0.0071158838,-0.19689125,-0.007270856,-0.032146566,-0.0011698884,0.020113137,0.011138221,-0.0115405945,-0.05994395,-0.022760259,0.00552236,0.05067699,-0.0385429,-0.061459877,0.053699855,-0.0450712,-0.0027615335,-0.0620876,-0.00091662345,0.027818248,-0.056559764,-0.08014365,0.03428952,0.03547412,-0.027454443,0.040838256,-0.0015382499,0.0389791,0.039594647,0.0670613,0.07126311,0.03183305,-0.071736276,-0.046950754,-0.02598982,-0.0676485,-0.055180073,-0.0070795803,-0.065039,0.053225208,-0.008269399,0.14874889,0.022966586 +1.5.1.34,The substrate is the quinonoid form of dihydropteridine. Not identical with EC 1.5.1.3 dihydrofolate reductase.,384,1.0,-0.07598891,-0.07857107,-0.03479807,-0.106267646,0.08901948,-0.058754977,0.031523928,0.047118556,-0.021724435,-0.064426295,0.0711985,-0.089625746,-0.03823477,0.012768415,-0.04527334,0.0061788205,-0.068397745,-0.07202833,0.0066067334,0.00073812413,0.020653544,-0.050867125,-0.055551473,0.0026083717,0.07131523,0.016559282,0.05774358,0.033063427,-0.05449776,-0.1065053,0.01293365,0.07408872,0.059737526,-0.015323781,-0.019121766,0.093235776,-0.04463494,-0.016986376,0.013044389,0.033383645,0.020388655,-0.054181874,0.020437242,0.03685904,-0.047623347,0.016540693,0.0044893967,0.12843773,-0.007045732,0.014858303,-0.023635965,-0.010206357,0.015847607,0.044632778,0.067166336,0.059101816,0.0012931541,0.06835617,-0.081157535,0.05450214,0.051772077,-0.02350405,-0.047373477,-0.058957987,-0.010336232,0.017121023,-0.035112385,-0.11979734,-0.0034192645,-0.044062324,-0.053014085,-0.07746973,-0.009847123,0.0004910463,-0.0012574185,0.03292379,0.019635698,0.014736082,0.03250796,0.029146334,0.015397752,0.043583002,-0.013057145,0.017214214,0.046368837,0.0056306114,0.0086460905,-0.0660897,0.003049261,-0.029066827,0.04287438,0.041517705,-0.06346439,-0.03189051,-0.08533882,0.10728091,-0.07011938,0.053257857,0.05516505,0.012648829,0.035097808,0.014660614,-0.05825084,-0.015168264,-0.13326105,-0.047736242,0.046989188,0.08079851,-0.074718505,-0.016502228,0.021343602,-0.018357486,0.008386493,0.05581794,-0.04817791,0.03139903,0.025326787,-0.036030576,-0.016503004,-0.0085591795,-0.011789609,0.043067157,0.03616337,0.03739532,-0.04060347,-0.033283517,-0.09766934,2.9733024e-33,0.032806117,0.042766567,0.0069592306,-0.014764511,-0.025591401,0.014070279,-0.093729444,0.05024945,-0.03730149,-0.10485614,-0.0640758,-0.03946812,0.005162597,-0.011984194,-0.06374103,-0.08415572,-0.04239752,0.027691666,0.012795202,-0.0076549808,0.01994604,0.034866016,-0.09051037,-0.035095006,0.036992192,0.0061565624,-0.06491649,-0.05546019,0.084326275,-0.0028885666,-0.003810141,-0.07596268,0.026995605,0.03097098,-0.053318676,-0.013670884,-0.06205786,-0.0036538173,-0.045864906,0.06626007,0.0436212,0.049036235,0.052225668,0.015108069,0.042282704,-0.03322151,0.015895553,0.07519881,0.06723024,-0.038706496,0.025584025,-0.010344286,0.12251589,-0.078995734,-0.0033785487,0.03859202,-0.04174151,0.03477132,0.048834022,0.051879045,0.020032786,0.14265697,-0.051418826,0.0276212,0.0032256383,0.041230492,-0.07423729,-0.05815161,0.01732226,0.03759987,-0.034356665,0.005854463,0.09187795,-0.0005766297,0.03545931,-0.041732043,-0.07583371,0.016969275,0.03291317,-0.0319841,-0.03454762,-0.001525763,-0.027856546,-0.035927203,-0.13320926,0.039545093,0.029373968,-0.03932727,0.038486563,0.03724106,0.031064034,-0.074376814,-0.05107122,-0.09617483,0.09516632,-2.4261397e-33,0.040119812,-0.096467234,0.007632224,-0.031021932,0.040957276,0.072029345,0.06789174,-0.00692494,0.045178402,0.014424255,0.035855845,0.031556036,-0.078973845,-0.038267367,0.002140018,0.010114694,0.010630221,0.02849881,0.023660725,-0.0017299223,-0.010864167,0.055863384,0.04404702,0.027289134,-0.0008135895,0.009911091,0.057749305,0.07353271,0.09847889,0.0060612727,-0.07588802,0.017708031,0.014881863,-0.013416308,0.0002798588,0.088583834,-0.107330464,-0.013445139,-0.06894449,-0.03900967,-0.06241906,-0.013443782,-0.02219596,0.03742933,-0.008282916,0.04909646,-0.0627358,0.061299656,0.01571834,-0.059553895,0.032945953,0.03431741,-0.03749529,0.016887391,0.029602071,0.0689014,0.040335737,0.00082799635,0.0057768417,0.0033078138,-0.048287787,-0.07855081,-0.011444599,-0.039205633,0.07147985,0.023676641,-0.032618407,0.16853814,0.010212762,0.053345595,0.064670324,-0.02652391,0.041013718,0.013930083,-0.030969206,-0.04738847,-0.037657037,0.05390505,0.0007558345,0.06430324,0.022006193,-0.04576023,-0.08782539,0.016086787,0.019654801,-0.0753963,0.06526861,0.053093717,-0.04779672,0.077857204,0.014821395,-0.027520401,-0.07719422,0.123721994,0.052160718,-3.0054235e-08,0.118217215,-0.072214834,0.020128679,-0.033362176,0.055314828,0.02449365,0.05652196,0.010140562,0.034140162,-0.040634513,-0.034378324,0.003633361,0.060343042,0.00917253,0.11543003,0.01931114,-0.0030944254,-0.037324786,-0.03443972,0.043762237,-0.01232766,-0.004785862,-0.14385827,-0.04289788,-0.02552315,-0.0037985598,0.015030085,0.038047064,-0.068975165,-0.00651512,0.0606209,0.07221648,-0.0034364497,0.009036075,-0.020702988,0.043205056,-0.063138254,0.031529658,-0.03590193,0.017211597,-0.014040895,-0.039307088,-0.03920429,0.014271751,0.023196084,-0.002527024,-0.029262345,0.0015451862,0.032730184,0.03667388,-0.014815433,0.02459708,0.04012813,-0.0200841,-0.061243027,-0.012812696,-0.016989773,-0.07111224,-0.01664594,-0.025826534,0.0036307597,0.051347446,0.19101661,0.05022372 +1.5.3.1,"The enzyme, reported from bacteria and fungi, catalyses the oxidative demethylation of sarcosine. It contains a FAD cofactor bound to an L-cysteine residue. cf. EC 1.5.3.24, sarcosine oxidase (5,10-methylenetetrahydrofolate-forming).",384,1.0,-0.05789932,-0.034715284,-0.12019879,-0.003387958,0.13516521,0.017587302,-0.026615364,0.07553827,0.055078704,-0.016710075,0.0019200261,0.026303146,0.008146755,0.06364924,-0.060125113,0.01986348,-0.11015927,0.043312706,-0.057951115,-0.07231775,0.057809174,0.039428934,0.036441058,0.0054717944,0.031067207,0.012788339,0.06914708,-0.052593745,-0.0652896,0.03868458,-0.008000815,-0.006788235,-0.009063201,-0.05180169,0.018222671,0.022771759,0.073850006,-0.023066653,0.040092744,0.039047696,-0.035940696,-0.011570196,0.023609823,-0.043914508,-0.020510394,-0.045381896,-0.000511608,-0.024286438,-0.0032141272,0.023187494,-0.05364104,-0.01568279,-0.07571246,0.042129617,0.04825831,0.049444273,-0.09937522,-0.06710565,-0.01567733,0.0562246,0.025606045,-0.009977045,-0.049076587,-0.0117947515,-0.044195246,-0.06003576,0.04228016,-0.07534596,-0.021672752,-0.04637825,-0.017269235,-0.09333549,-0.001834804,-0.020793533,-0.010474481,0.022534274,-0.001277996,-0.07545116,0.04972673,-0.050171036,0.02339182,0.02548039,0.07836286,0.09798857,0.034960013,-0.0069173533,0.08997092,-0.015442786,0.13315155,0.03291112,0.022539033,0.027394298,-0.089038916,-0.011887093,-0.053952977,-0.015223297,0.08524663,0.1050913,0.017444534,0.0043633967,0.029492116,0.029165778,-0.010350025,-0.05118231,-0.05391711,0.01787002,-0.01312023,0.109731704,-0.0036170227,-0.035209104,0.0068830075,0.087528884,-0.048597183,-0.01205057,0.0127597395,0.10382941,0.04681093,-0.10405134,-0.13674292,-0.04542061,-0.012556223,-0.046860173,0.010833737,0.052275687,-0.0024325298,0.031623147,-0.08799496,1.12145265e-33,0.05157098,0.10807623,0.031624388,-0.041211303,0.032505125,-0.039728016,-0.06404428,0.024712633,-0.016872458,0.031551003,-0.0659253,0.0005707565,-0.038973078,0.034405492,0.013169864,0.0034610494,-0.040298272,-0.082624696,0.005215424,-0.024632853,0.047185365,0.05325574,-0.021624194,0.023144865,0.024855912,0.0015881034,0.02388408,0.019376753,0.040105373,0.02649901,-0.029237911,-0.13068916,-0.038773164,-0.03795412,-0.016388668,0.05891209,-0.09955692,0.0234373,0.008426116,0.07822913,0.08972043,-0.0007282272,0.017816197,-0.05727505,-0.044964183,-0.099053144,-0.008325765,0.08112221,0.026740754,0.11222464,0.029687436,-0.00030668115,0.05809234,-0.0057037096,-0.038420152,-0.007769292,-0.0635179,-0.017355533,0.05753052,0.033758674,0.001994759,-0.06575019,-0.029746622,0.065165125,-0.0071622115,-0.008897306,-0.028192332,-0.046873033,0.014025781,0.054489356,-0.032824025,0.008626212,0.06442575,-0.011931547,0.05547717,-0.048164006,-0.0355184,0.07409754,0.07438354,0.014757106,0.0078845695,0.029534768,0.0017037574,0.009026052,-0.058586154,0.06050913,-0.016958525,-0.024401074,-0.065272026,0.027598852,0.027487919,-0.05053963,0.031167848,-0.0006850005,-0.023366803,-1.5736769e-33,0.090653755,-0.10926576,0.03208848,-0.12982273,-0.04595629,0.0083106365,0.047995843,0.005831393,0.010109071,-0.06636028,0.019674933,0.009812441,0.041845363,0.004206093,0.006026724,-0.028683549,0.029819725,0.055015888,0.018723575,0.0269744,0.04431138,0.04725526,-0.009009824,0.011168804,0.034688953,0.0091674505,-0.026369076,0.017928204,0.022590201,0.045532405,-0.022828914,-0.025359944,-0.02532002,-0.050210133,-0.03789053,0.069549635,-0.034943182,-0.009085602,-0.012231842,0.037953906,-0.072055265,-0.020407455,-0.02082405,0.124021046,0.040361945,0.049029823,-0.0883308,0.015223548,0.03138968,-0.12478966,0.04070505,-0.032922387,0.0018525614,-0.036154486,0.059827533,0.0491416,-0.0067996783,-0.007460405,0.020447038,-0.029147016,-0.057943743,0.013831187,-0.019419128,-0.038432986,0.08846553,0.072885126,-0.018778652,-0.014612909,0.030558104,0.016838813,0.08934553,0.047162056,-0.010556893,0.019520754,-0.00521978,-0.09259875,-0.04446461,0.060748734,-0.048630867,0.052621722,0.093539335,-0.01652144,-0.02151869,-0.09481377,-0.10302335,-0.038190793,0.052312374,0.13918366,-0.012289851,-0.004901132,-0.03961128,0.0027254988,-0.019157805,0.061858654,0.08165238,-3.4938957e-08,-0.011496081,-0.0826008,0.008742166,-0.039065145,-0.008246027,0.1008034,0.080550246,0.03071479,0.05762849,-0.05474347,0.016320435,0.11556423,0.02864928,0.044015713,-0.064740345,-0.021810587,-0.06804438,0.037493408,-0.025100468,-0.034420643,-0.035969116,0.049367264,-0.03009501,-0.009876093,0.021361222,-0.021120239,0.04190831,-0.0023863283,-0.06859904,0.015302929,-0.017450761,0.027858855,-0.026443576,-0.033998083,-0.07716953,-0.0018087009,0.04324638,-0.003236557,-0.009157294,-0.0023248133,0.02574999,0.01471338,-0.11468693,0.031943526,0.033744734,-0.005363705,-0.06888299,-0.01682452,-0.005897141,-0.00013537174,0.06292435,-0.028781548,-0.022726046,-0.09960333,-0.1143786,-0.020939553,0.012377042,-0.05920476,-0.030042507,-0.08380525,-0.023409246,0.026704773,0.16942647,-0.017404376 +1.5.3.2,A flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.5.3.5,"A flavoprotein (FAD). The enzyme, which participates in nicotine degradation, is specific for the (S) isomer of 6-hydroxynicotine. The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyses a similar reaction with the less common (R)-isomer (cf. EC 1.5.3.6, (R)-6-hydroxynicotine oxidase).",384,1.0,-0.082593165,-0.055179328,-0.09632175,-0.00033601504,0.09046255,0.031168481,-0.018350776,0.05910225,0.049403474,-0.04745204,-0.0031836054,0.03294071,-0.119304724,-0.021281702,-0.041770425,0.02048048,-0.065662295,0.0444395,-0.050618283,-0.0036795498,0.0020380067,0.028501602,0.045453846,-0.01916841,0.018866913,-0.0135693345,-0.01720712,-0.046861872,-0.012162271,0.02068813,0.09446709,0.007269109,0.055784106,0.012753916,-0.03942504,0.009161644,0.025957936,-0.010575146,0.024980763,0.020414606,0.008984401,0.033433244,-0.002923788,-0.010303603,0.051347546,0.0214666,-0.018961722,0.042827953,-0.009768655,0.023012778,-0.0041926587,-0.06708711,-0.117293805,0.023964975,-0.01514067,-0.0055584167,-0.020058015,-0.056729708,0.014483066,0.039635837,0.039360806,-0.013355111,0.04091793,0.0097734155,0.07659913,-0.10806025,0.001911784,-0.057852868,0.03827853,-0.049646884,-0.05214993,-0.0660076,-0.054941416,0.0430414,-0.015678087,0.063639596,-0.14745557,-0.018957863,0.06294005,-0.0032127127,0.06820477,-0.06278232,0.044569284,0.13757609,0.05753222,-0.06823435,0.019475171,-0.015505859,0.02029535,0.04352054,0.010687037,0.053864658,-0.008483873,0.023174157,-0.1269744,0.019351091,0.086505234,0.01194913,-0.04922624,0.0057628118,-0.03364159,0.03073876,-0.019315308,-0.032479163,-0.0511622,-0.051326588,-0.033873536,0.07033406,0.0058487756,-0.030560466,-0.039305154,0.017940426,-0.005606403,-0.05590486,0.026923325,0.04173641,-0.023111895,-0.047946263,-0.0030585586,-0.01764736,-0.06377079,0.07388343,0.07408858,0.0823542,0.04730368,0.0015085343,-0.0910384,-2.7741072e-34,0.048998073,0.017457748,-0.013414956,0.0043270364,0.030048149,0.01449696,-0.047730975,0.012988778,0.044469748,-0.0433511,-0.032618627,-0.042933077,0.012805826,-0.004705314,0.03488669,0.030866189,-0.08480855,-0.04836985,0.096317925,-0.109585784,0.042987492,0.021503236,-0.006161003,0.070815176,-0.023090929,0.014992683,-0.07834266,0.033901773,-0.019159734,0.023390893,0.0021492362,-0.03394157,-0.07582685,-0.054540936,-0.004482679,0.080686435,-0.034386408,-0.05673013,-0.12948409,0.05133754,0.03434071,-0.022367725,0.0042625717,-0.023920696,0.058941238,-0.049953,-0.08882475,0.10489209,0.03466168,0.085705906,-0.04096774,-0.07401896,0.1343548,0.03353417,-0.08219463,0.03341674,-0.01619165,0.0025146108,-0.050332397,0.009348938,0.025161194,0.08055148,0.0101356255,0.10659791,-0.07422362,0.020769821,0.0015383693,-0.10834527,0.020877508,0.13790752,0.017452069,-0.0001396785,0.081295885,-0.01095896,0.055491015,-0.08233151,-0.07191998,0.008479518,-0.027338998,0.0066495216,-0.04479484,-0.02374181,-0.014346489,-0.030256288,-0.039135344,0.0026161044,0.022325294,-0.035794698,0.009083396,0.05811272,0.04803254,-0.06976486,0.0015289851,0.047330983,0.032697037,3.9831745e-34,0.0036434024,-0.08121694,0.06027782,-0.003780352,0.021183599,0.039453536,0.038904384,-0.0007737092,-0.0096592875,-0.049693663,0.02725721,-0.053395834,0.022147989,0.027124455,0.0489323,0.014019054,-0.035651375,-0.0005055078,0.041135315,0.036686763,-0.080773614,0.03191115,0.027587308,0.08547848,0.03575234,-0.008262165,0.04106591,-0.013114543,0.03904239,0.0006209457,-0.007794904,0.07871921,-0.040363714,-0.016965047,-0.06110707,0.0644634,-0.024663294,0.0148224225,-0.044640657,-0.0033473575,-0.00983306,0.0028436817,-0.04756906,0.040447336,0.07379011,0.032053575,-0.013355871,0.042692523,0.049935333,-0.01972601,0.07419912,-0.0059050582,-0.014392184,0.0615809,0.07968027,0.061483935,-0.03138653,0.06625665,-0.0397103,0.008279689,0.006019409,-0.0941946,-0.006118218,-0.009911342,0.10271573,0.06327078,0.044928912,0.14267047,0.029904738,-0.018529572,0.1285765,0.005985039,0.03234591,0.050842725,0.020151094,-0.078430146,-0.010877485,0.05895539,-0.012955724,0.010492725,0.0010135712,0.020715175,0.005749639,0.002557099,-0.08276613,-0.1025263,-0.031138545,0.08949423,-0.015770257,0.044318125,-0.015300451,0.006000842,-0.055794187,-0.07125612,0.045866296,-3.8014242e-08,0.05252635,-0.07932207,0.010225518,-0.010352454,0.097020686,0.04495242,-0.034214042,-0.0066324663,-0.005448483,-0.013826989,-0.019205108,0.12796952,0.0029245287,0.017203555,0.017123451,-0.04788232,-0.054505203,0.06523478,-0.02438124,0.04857025,-0.11584758,0.053839818,-0.05081184,-0.029142462,-0.024717266,-0.03159817,-0.0134380255,-0.015196725,0.047629874,-0.0017159383,0.035781454,0.008957417,0.038092993,-0.03448031,-0.13516903,0.018461548,0.043738365,-0.079676114,-0.035225056,0.0332102,-0.063639425,-0.031091671,-0.07754896,-0.02340168,0.0315937,-0.018168194,0.001473855,-0.009290828,-0.060454402,-0.002663653,-0.004979338,0.002213372,0.013152367,-0.04634305,-0.095562845,-0.053533282,-0.01645932,-0.070253834,-0.037073087,-0.06538471,0.04806876,0.010957655,0.16198736,0.014020785 +1.5.3.6,"A flavoprotein (FAD). The enzyme, which participates in nicotine degradation, is specific for (R) isomer of 6-hydroxynicotine, derived from the uncommon (R)-nicotine. The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyses a similar reaction with the (S)-isomer (cf. EC 1.5.3.5, (S)-6-hydroxynicotine oxidase).",384,1.0,-0.086595945,-0.040246315,-0.107434355,0.0037268698,0.09809836,0.037900846,-0.01604665,0.062371347,0.045187294,-0.034967564,-0.012166452,0.03633195,-0.11852516,-0.016542993,-0.034687728,0.015013265,-0.06295041,0.051354334,-0.04872085,-0.0015561893,0.0005546593,0.037566494,0.038568556,-0.020709725,0.028033014,-0.0049378206,-0.02158013,-0.051199857,-0.003359224,0.028270785,0.099382564,-0.006191063,0.06758983,0.010329598,-0.035297673,-0.003813953,0.021791829,-0.00706313,0.039011016,0.012567997,-9.99927e-06,0.04667071,-0.0049840887,-0.0082674185,0.047688335,0.025420165,-0.025271885,0.05128074,-0.012166558,0.020109624,-0.010845859,-0.054882802,-0.11548699,0.028801618,-0.0015388675,-0.008492641,-0.024740886,-0.07005898,0.0041493257,0.027515884,0.04762348,-0.025652878,0.048538256,0.006629865,0.052799508,-0.10275198,-0.00041181204,-0.05410631,0.052863516,-0.047323953,-0.059425335,-0.06146856,-0.065077126,0.03682884,-0.0065521924,0.06207014,-0.13745785,-0.001930688,0.06446149,-0.0044794567,0.076038115,-0.057308897,0.035717543,0.13330343,0.04414483,-0.05648572,0.026832426,-0.023296017,0.027833711,0.03534869,0.028979102,0.050560888,-0.008319511,0.02015173,-0.14200078,0.011474733,0.08078341,0.011968318,-0.042421415,0.0018908973,-0.030334715,0.027282972,-0.0124844825,-0.036570247,-0.071405545,-0.047124393,-0.043695144,0.07116536,0.008995582,-0.035102345,-0.030947695,0.011214593,-0.017996697,-0.047092166,0.015959408,0.04550701,-0.026661407,-0.048877586,-0.0060305092,-0.010377675,-0.064409316,0.07060136,0.07541548,0.07674177,0.05028985,-0.010641808,-0.101036176,-3.2146313e-34,0.051260587,0.02957256,-0.017959535,0.0075609162,0.037018303,0.011212759,-0.04799027,0.014875004,0.05403681,-0.031357236,-0.03316684,-0.054248385,0.018014919,-0.01400828,0.029575715,0.044573568,-0.08545144,-0.05546351,0.08148201,-0.09326294,0.041760106,0.025836417,-0.0040017497,0.07345158,-0.016752781,0.018368378,-0.07538137,0.0278855,-0.012510271,0.02099945,0.009487121,-0.031577483,-0.08356083,-0.053159356,-4.8201382e-05,0.07525254,-0.02641433,-0.06114524,-0.1247864,0.05273121,0.041462913,-0.023266181,0.002461168,-0.01200326,0.055934712,-0.050119516,-0.08942783,0.11626126,0.045251764,0.10057919,-0.049883157,-0.071641,0.13483688,0.028291935,-0.08343004,0.03224435,-0.027422747,0.014642523,-0.040340733,0.008971732,0.02334678,0.07651019,0.011104456,0.09939653,-0.07705778,0.020107875,0.0028139863,-0.12089403,0.026640583,0.1375807,0.02198379,-0.015236552,0.07622027,-0.012499906,0.06086311,-0.081711754,-0.07700788,0.0014486277,-0.013781936,0.011767999,-0.06002196,-0.015666436,-0.011480988,-0.036745887,-0.03444166,-0.012431126,0.012897145,-0.045344576,0.011352529,0.060613062,0.044657134,-0.06442572,-0.005735949,0.049417723,0.0297215,3.4670393e-34,0.007747494,-0.084370896,0.050989654,-0.003263655,0.014450489,0.038710974,0.026330926,-0.001704574,-0.009071319,-0.049305603,0.02528297,-0.05489052,0.025970258,0.043133646,0.053745717,0.0070962436,-0.021628868,1.1084637e-06,0.031091336,0.044151098,-0.08183694,0.026930464,0.03223189,0.07274386,0.035039663,-0.004233916,0.047244076,-0.0015511779,0.04764217,-0.0118358815,-0.00022367481,0.082771845,-0.042199392,-0.015686201,-0.06569197,0.07014446,-0.008536386,0.013029249,-0.04040108,0.0024220143,-0.005667092,0.002356876,-0.04326805,0.037817825,0.06876602,0.012089485,-0.02083979,0.04871789,0.0465422,-0.029804604,0.072821885,-0.007536322,-0.014828924,0.05642039,0.07635157,0.06233072,-0.030105434,0.073424354,-0.03802749,0.013112467,0.003618676,-0.09686506,-0.0092758,-0.007017411,0.09730409,0.06401536,0.059931614,0.1306295,0.035818096,-0.03072457,0.1224107,0.0071443855,0.031702865,0.055192385,0.015526616,-0.071766555,-0.020561028,0.046151698,-0.002543746,-0.0007767452,-0.004676132,0.016001664,0.014092109,0.005053405,-0.086067505,-0.10509633,-0.037126247,0.08786117,-0.013710616,0.042810205,-0.017705861,0.0057601905,-0.053144217,-0.061208915,0.04940901,-3.787076e-08,0.05445602,-0.07585292,0.005372862,-0.012176299,0.10802973,0.05209847,-0.032927267,-0.015272045,-0.014469273,-0.0066524073,-0.019982757,0.11375484,0.0040898477,0.011766509,0.02722118,-0.04285313,-0.04942618,0.06977667,-0.025364412,0.0525643,-0.10910436,0.053155337,-0.045899797,-0.035113376,-0.016857836,-0.03183418,-0.005997213,-0.030040644,0.05011987,-0.010922094,0.034718335,0.0060792617,0.049824413,-0.024810536,-0.14460808,0.0028922183,0.04202151,-0.075143196,-0.041878168,0.032379076,-0.06497662,-0.0145339295,-0.08567375,-0.020954797,0.01746134,-0.022555767,-0.010169172,-0.009029156,-0.07665348,-0.016650327,-0.0026094518,0.0044863145,0.003796356,-0.044558324,-0.104379766,-0.059468184,-0.020292033,-0.06023224,-0.03510439,-0.055034515,0.04211598,0.01985812,0.14470996,0.017414581 +1.5.3.7,The product reacts with water to form (S)-2-amino-6-oxohexanoate.,384,0.99999994,-0.04646493,-0.07063011,-0.039532226,0.009482906,0.09774043,0.09470344,0.046996396,0.05771462,0.0033062152,0.01570779,0.013340964,-0.06882771,-0.056663282,0.01844871,-0.07587896,0.10651133,-0.03035286,-0.016657483,-0.0008864691,0.017098052,0.071723185,0.007135536,0.03362834,0.04138798,0.037275612,0.07878917,0.10518768,0.029560646,0.0049098236,-0.027000964,0.055014443,-0.035165954,0.061991755,-0.08693476,0.0117190005,0.04780174,0.0054753525,-0.10187277,-0.011719255,-0.039841793,0.026370844,-0.049494594,0.017621266,-0.07128943,0.058757316,-0.023759289,0.05291203,0.046023592,0.029180406,0.023834677,0.0012622144,-0.12026285,-0.09180185,-0.002723958,-0.021395238,-0.0056467745,-0.07169057,-0.022079872,-0.005042619,0.008389207,0.05469327,0.028889727,-0.048399746,0.040698763,0.049886342,-0.039208356,-0.039227493,-0.015320434,-0.004647921,-0.030998835,-0.025027374,-0.049702905,0.0708178,0.02480232,-0.047424354,-0.032156017,0.006784259,-0.08073013,0.11493807,0.006646256,0.028723361,0.012144493,0.0092298305,0.1154795,0.030233413,0.070588335,-0.018260017,-0.06385449,0.013364259,-0.047160782,-0.024525715,-0.009740457,-0.023743222,-0.06461725,-0.057366088,0.062475868,0.030742686,0.0676278,0.04994434,0.067656174,-0.03664271,0.07087313,-0.055587724,-0.16613878,0.010812656,0.005065962,-0.057769682,0.06105769,0.026732033,0.03195186,-0.04929274,-0.07177978,-0.0245689,0.06285523,-0.0385362,0.09385786,0.019263072,-0.0092373,-0.07126604,0.0021415313,0.013189256,0.032363962,0.03440719,0.0748323,-0.06419067,-0.03738803,0.008518683,-3.7592688e-33,0.051406078,-0.072884135,0.020755962,0.061385237,0.015722688,-0.059557356,-0.04975279,-0.06225113,0.01106369,0.012848239,-0.13784559,-0.040974095,0.03343091,0.039048977,-0.026042288,-0.0515221,-0.002194494,-0.005490537,0.0408051,-0.008008609,0.00081347005,0.072387874,-0.014884851,0.020659713,-0.018277768,-0.07729718,-0.005912706,-0.018076943,0.061701786,-0.01799472,0.016339192,0.01433304,-0.049696743,-0.07682922,-0.023313481,-0.036118142,-0.047460333,-0.08186817,0.05273529,0.037403718,0.041647065,0.0097210985,-0.05337312,0.029267734,0.072691366,-0.019704733,0.0013265597,0.08528595,0.12880422,0.0010984292,0.021025443,-0.05717721,0.053821154,0.04773665,-0.04613207,-0.03713246,-0.027434358,0.009444463,0.07685047,0.06238833,-0.09370997,0.06773264,-0.008907629,0.032557048,-0.038589314,-0.037732337,0.0035163735,-0.006258675,-0.005392867,-0.0004163028,-0.048162185,0.019992433,0.07225842,0.017516145,0.013622208,-0.11191384,0.00826237,0.021291919,0.022795666,0.021820258,0.053841002,-0.051420677,-0.011042917,0.0481942,-0.055135626,0.025363566,-0.042837456,-0.041985795,-0.025200281,0.10189591,0.11090437,-0.06082931,-0.06505415,-0.018871864,0.044385694,1.633223e-33,0.05446289,-0.14436686,-0.064781494,-0.022043435,-0.03786263,0.022105709,0.033641547,-0.00023479169,0.019692283,0.019039705,0.06252588,-0.0017404741,0.04206604,-0.052357547,-0.031390518,0.011084013,0.015673315,0.07977459,0.06824102,-0.021386446,0.041622765,0.020743933,0.0024589554,-0.0072334805,0.07480973,0.010502133,0.053004935,-0.015275797,0.06690847,0.056419376,-0.037869606,-0.083193436,-0.012887555,-0.015302853,0.012341245,0.045028616,0.010103523,-0.0432075,-0.05720353,0.00848176,-0.027355334,0.00660369,-0.004719784,0.07672574,0.09202424,0.05790954,-0.04238496,-0.02566561,-0.053464085,-0.06457874,0.076302,-0.05707007,-0.09677856,0.015253434,0.017127642,0.020539785,-0.008506279,-0.08007524,-0.023601225,0.005526198,-0.008394785,-0.05786602,0.03547475,-0.07182001,0.0013106852,0.08519056,-0.03968478,0.06558351,0.029657004,-0.020413369,0.08626595,-0.02169909,0.03156518,-0.026449943,0.04350494,-0.10829771,-0.026226476,-0.011073939,-0.018049952,-0.091192365,-0.039530963,0.056054354,-0.011984848,0.0077618877,-0.01109628,-0.028015476,0.037694357,0.087018706,-0.01873187,0.09165553,-0.00041839917,0.0028524888,-0.0653689,0.06516541,0.091506176,-2.620403e-08,-0.033603117,-0.11133642,0.1039808,-0.0014601166,0.0047919117,0.086185835,0.087799706,0.00902016,-0.012138689,-0.1053022,-0.016942687,0.07449669,-0.020170871,-0.01659107,0.011442847,-0.0048992825,-0.0061903587,0.040735766,-0.07973744,-0.024687622,-0.059918545,0.00075829896,-0.010386878,-0.030625025,-0.020854512,-0.032959864,0.016743954,0.06856512,-0.047842342,-0.060947977,0.0056214035,-0.0047642286,-0.053216863,-0.012447189,-0.018128568,0.007660225,-0.004031575,-0.02446495,-0.059335865,-0.02124397,-0.07948395,-0.0014837687,-0.014482926,-0.0007506712,0.059399687,0.022954248,0.00455649,0.010342751,-0.01487701,0.021468265,0.09090174,-0.048766147,-0.0068868194,-0.030766929,-0.088947035,-0.0026332862,0.0049094954,-0.099931546,-0.0024203658,-0.019417735,0.016503442,-0.015173018,0.18129802,0.04633853 +1.5.3.10,"A flavoprotein (FAD). The enzyme, characterized from the bacterium Arthrobacter globiformis, contains two active sites connected by a large ""reaction chamber"". An imine intermediate is transferred between the sites, eliminating the production of toxic formaldehyde. In the absence of folate the enzyme does form formaldehyde. Does not oxidize sarcosine. cf. EC 1.5.8.4, dimethylglycine dehydrogenase.",384,0.99999994,-0.054788407,-0.061239924,-0.12347752,0.010467467,0.13034227,-0.01776746,-0.018870544,0.0631726,0.06317309,0.00025503486,-0.0004144532,0.022195928,-0.06051094,0.032535538,-0.064394034,0.031467725,-0.064877294,-0.011058951,-0.052845117,0.002349705,-0.012321271,0.055236865,0.021674959,-0.03892013,0.012372436,-0.045183796,0.02806837,-0.044715874,-0.079598874,0.0072524427,0.0674945,0.044467773,0.06817363,-0.03407446,0.004132868,0.068605244,0.06990528,0.0042931107,0.0033786695,0.0010302806,-0.026711237,-0.024151735,0.035924952,-0.02244239,0.045334052,0.03017596,-0.027418792,0.037834153,-0.014900798,0.031745594,-0.060329672,-0.035940208,-0.14173779,0.07207712,-0.0071872436,0.004098917,-0.028291889,-0.07864592,-0.040005896,0.013684734,0.013644253,4.319576e-05,0.01681202,0.008408749,0.06545895,-0.0803857,0.002955802,-0.06712299,0.03896477,-0.040324032,-0.015221693,-0.07391184,-0.060897194,0.021713892,0.008381005,0.009731239,-0.094943896,-0.012333246,0.11418795,-0.016430987,0.04130814,-0.03017439,0.10967663,0.07585745,0.04174797,-0.048787404,-0.0064336117,-0.020049173,-0.0012243052,0.07174314,-0.014301568,0.025008129,0.0020531132,-0.0003131673,-0.04246186,0.029536815,0.06337234,0.023469111,-0.008094988,-0.0028161835,-0.06803242,0.012638943,-0.0034510663,-0.00016313519,-0.06683691,-0.09010971,-0.024558706,0.11451385,-0.026192559,-0.06601287,-0.026430853,0.014915884,0.0053972714,-0.05614998,0.034392808,0.06429181,0.027828066,-0.07939295,-0.016528606,-0.0037327074,-0.031119809,0.06639624,0.08128706,0.10707465,0.035985213,0.007727399,-0.09078576,3.0965923e-33,0.080279134,0.02098454,-0.003962977,-0.024989298,-0.007256024,-0.016163737,-0.0719518,-0.002915512,0.064564764,0.011681021,-0.035233915,-1.2654441e-05,0.015654907,0.026615098,0.06396532,0.04359012,-0.0837054,-0.025859091,0.10129657,-0.05590334,0.047883213,0.05954737,-0.00048554075,0.052579984,0.040144924,0.028260052,-0.050843377,0.06364147,-0.018420924,0.030071184,0.020623341,-0.09117132,-0.08129804,-0.02201036,-0.054728292,0.05480916,-0.10957744,-0.044363514,-0.09571312,0.054534033,0.035023216,-0.019572197,-0.014489302,0.0046377135,0.0428641,-0.035434585,-0.08486367,0.10590496,-0.017760972,0.10258319,0.04234236,-0.03474005,0.1246701,0.02698871,-0.07643599,0.028820595,-0.031663787,-0.024538903,-0.0045327055,0.027684592,0.03782131,0.029544197,-0.04554275,0.1122044,-0.07319685,-0.022864493,-0.0369714,-0.05013538,0.037226263,0.096052706,0.039626796,-0.01603259,0.106095836,-0.00365988,0.009611927,-0.06417862,-0.0704742,-0.028763913,-0.033697434,-0.0057771783,0.0062801223,-0.012251662,-0.03427507,-0.0075015468,-0.023776224,0.030537894,-0.03694096,-0.070850514,-0.0019360427,0.01026623,0.020954294,-0.04005585,-0.029143872,0.038312305,0.042478103,-2.3218491e-33,0.0918172,-0.08642321,-0.0140825985,0.023401413,-0.014400265,0.024479276,0.050490424,0.008042106,0.06864036,-0.019423604,0.03623129,-0.04561725,-0.017993823,-0.0051908246,0.040296756,-0.0065448093,-0.024442196,-0.0067212335,0.026481755,0.029188294,-0.0394788,0.014958012,0.05665672,0.031960614,0.036727596,0.009148548,-0.04700484,-0.007956568,0.011528022,0.036874056,-0.027245164,0.055569705,-0.03647346,-0.042122997,-0.04468953,0.036942925,-0.040612362,-0.016371142,-0.022597555,0.008978473,0.004407466,0.027640691,-0.040124252,0.0980614,0.048287567,0.06788595,-0.05969196,0.005806597,0.060866296,-0.080164,0.019343968,0.007112852,-0.031799715,0.011992006,0.03832056,0.08693607,0.0147530055,0.057111762,-0.057917077,0.019414952,0.012830588,-0.097184144,0.02119754,-0.031531155,0.08571971,0.07342863,0.039181963,0.12583461,0.017622646,0.058219247,0.11539971,-0.027770922,0.003593549,0.06356219,0.020607704,-0.05887839,0.0034186884,0.065229535,0.031397793,0.043921206,0.02931201,-0.012955747,0.0127691645,0.008653209,-0.06985349,-0.12428786,-0.028599165,0.08340042,-0.008623421,0.054860152,-0.014370525,0.04700328,0.016652334,-0.036210906,0.020849558,-4.037589e-08,0.010230915,-0.06409736,0.030393396,-0.02652555,0.061569456,0.011918126,0.009098861,-0.0030588766,0.0150794005,-0.030497257,-0.06716165,0.11865354,-0.0011153412,-0.01642132,0.01740036,-0.033595793,-0.031022595,-0.004983579,-0.066154,-0.045102093,-0.11299845,0.06440827,-0.10501311,0.026232632,-0.013152376,-0.048979223,0.021765552,-0.01939729,0.051972356,0.04449832,-0.023435311,0.08787065,-0.007752666,-0.052357435,-0.1746166,0.025812477,0.060487606,-0.0677868,-0.043012425,0.031476445,-0.065072514,-0.013560677,-0.07562191,-0.047188465,0.051698964,-0.016162155,0.0031269568,-0.03391685,-0.09497985,-0.013455444,0.035626255,0.018880926,0.009233724,0.031424727,-0.0775608,-0.016480468,-0.03726066,-0.080084674,0.014763772,-0.056822494,0.011870412,0.02089906,0.1563802,-0.030575905 +1.5.3.11,"A flavoprotein requiring Fe2+. Also acts on N1-acetylspermidine and N1,N12-diacetylspermine.",384,1.0,-0.011864791,-0.05725923,-0.10585776,0.09681879,0.078522824,0.018730214,0.048765846,0.022346731,-0.028662598,-0.09681199,-0.06306277,0.02144854,-0.08123491,0.03281741,-0.079389475,0.013491397,0.021971455,-0.009613483,-0.009940856,0.0008697765,-0.008172892,-0.024875933,0.05684317,-0.069061175,-0.0608378,0.023136673,0.047628645,-0.030395092,-0.009150882,-0.0859008,0.021282675,-0.014428381,0.08913874,0.006415254,0.005606145,-0.010426216,0.019493464,0.016392628,-0.0117898835,0.03631762,0.019033765,-0.005565616,-0.042677753,0.029481221,0.018461311,-0.08856859,0.014163226,0.019921502,0.02563214,0.09771578,-0.023462977,0.0071658003,-0.032792915,0.085376315,0.07585634,0.05019057,-0.046302047,-0.016486723,-0.056046244,0.0643662,-0.0065339687,-0.029698873,0.052415706,-0.03534903,0.06562322,-0.026162295,0.019231945,-0.03145889,0.0701238,-0.022546398,0.021446582,0.0010515272,-0.065367915,0.012792691,0.021672023,0.03693423,-0.027643189,-0.007044995,0.12621905,-0.0074095186,-0.02237639,-0.011630112,0.01819929,0.047369886,0.050638527,0.0037795424,-0.08227928,-0.025066884,-0.0016938645,0.08239123,-0.024304776,-0.04485669,0.028138831,0.03884219,-0.025709933,-0.03260477,0.019257272,-0.051051546,-0.08948857,0.016139695,-0.07446552,0.034898154,0.032229517,0.031480562,-0.058105394,-0.008579813,-0.017821623,-0.0017983012,-0.041147996,-0.016758824,0.017861895,-0.030666603,0.05319445,-0.0026983004,0.02775243,0.036720913,0.015674548,-0.011934335,0.007887553,-0.020589188,0.054691017,0.061478905,-0.007621791,0.08016565,-0.038732644,0.0021783286,-0.0867418,3.732884e-33,0.053939167,0.048120514,-0.001770864,0.071341805,0.033869192,0.05344156,-0.017676894,0.00016999929,0.12499279,-0.0689244,-0.042957805,-0.030749688,0.06647656,-0.023852507,-0.022132637,-0.044702977,-0.01665705,-0.036261488,0.11929779,-0.051932327,0.009450988,0.07857195,-0.0028095718,-0.02135389,-0.014278406,0.025268646,-0.090786874,0.029453982,0.06139589,0.01713756,0.0038318494,-0.068932205,-0.027605593,-0.0032417045,0.0017860804,0.037240706,0.0077957986,-0.058839627,-0.07013886,0.05906368,-0.065261394,0.0533899,-0.064092994,-0.0005888362,-0.017024217,-0.101552375,-0.09656122,0.082790405,-0.040218253,0.10530483,0.010228015,-0.081618324,0.08443093,0.060049765,-0.069374986,0.027348733,-0.058689635,-0.06748743,-0.0075111724,0.031004418,0.059385464,0.0149605805,0.049282037,0.007382995,-0.012149616,-0.049278274,-0.048358068,0.022759883,0.01451791,0.086218104,-0.012273524,0.04357295,0.10808852,0.027132027,0.044918694,-0.06906469,-0.10169175,-0.009897926,0.025240561,0.029393034,0.0026206682,-0.07324963,0.040357012,0.007031683,-0.07396889,0.024964927,0.01102787,-0.06228714,-0.01359744,-0.01172839,0.033443995,-0.016222991,-0.0035513549,-0.005364597,0.06352124,-3.704743e-33,0.005455325,-0.11529653,0.0029783794,0.062354643,-0.053794917,0.007260158,0.01139967,-0.13165638,-0.061138198,-0.005734173,0.025622074,-0.08853684,0.025602523,-0.0595509,0.016374368,-0.0067500016,-0.0651464,0.116180934,0.04616472,0.016442876,-0.053517867,-0.016091751,-0.026330855,0.07900678,0.07169122,-0.0101817455,0.0048212046,-0.060143553,0.010051035,0.085207775,-0.016126715,0.064607434,-0.052839015,-0.114025325,0.015746517,0.019773096,-0.0073806695,-0.0076556914,-0.03305958,-0.032798924,-0.009165568,0.04075673,0.031014267,0.08958838,0.004015803,0.054364946,0.033448327,0.0890969,0.022154829,0.030392619,-0.016571218,0.003956052,-0.07558129,0.0939817,0.026783252,0.026310269,0.047087803,0.06331008,0.013283899,0.058542356,-0.024861729,-0.064011045,-0.045064446,-0.0343856,0.103388324,0.0083268145,-0.011600942,0.16759469,0.083528005,0.024367996,0.05443822,-0.004758503,0.14877658,0.025795862,-0.03080529,-0.06350526,-0.048581563,0.027441554,-0.019902503,-0.015993621,-0.035227507,-0.046896335,-0.022248022,-0.011010301,-0.058885243,-0.08906645,0.04489211,0.071163766,-0.039061014,0.017212022,-0.021968711,-0.029037092,-0.10020338,-0.050125152,-0.04952125,-2.8876762e-08,0.017826714,-0.07285666,-0.017416216,-0.020502787,0.026592754,0.024822548,-0.06551799,-0.009930604,-0.029108772,-0.050842386,0.02379193,0.15434754,0.030128945,-0.0035629952,-0.0006312806,0.0044258763,0.06383752,0.08095695,-0.003962137,-0.015259831,-0.11940474,-0.008130346,-0.10547911,-0.009422467,-0.040838335,-0.0785213,-0.02437982,0.04622861,0.13843822,-0.05619899,0.037056018,0.017231705,0.020504344,-0.116851844,-0.048559863,0.029343018,0.02771563,-0.037978567,0.009394687,0.016457336,-0.06974266,0.043681003,0.016357874,-0.017883688,0.008976587,-0.03142924,0.048186876,-0.013708464,-0.0517644,-0.03801119,-0.006748783,-0.004939205,0.03551114,-0.020170908,-0.014262437,0.048606478,-0.022029456,-0.0117460145,0.052129112,-0.024207529,-0.06712231,0.030408889,0.07504424,0.0083045205 +1.5.3.12,A CuII enzyme found in higher plants that produces oxidized forms of the benzophenanthridine alkaloids,384,1.0,-0.07823289,-0.02580425,-0.08122938,-0.035498433,0.019751087,0.09602652,-0.09619718,0.0028344428,0.058314092,-0.041125007,0.02198355,-0.08677146,-0.0042328034,-0.06006399,-0.1036286,0.031733293,-0.08410979,0.028058475,-0.07829738,-0.05904127,-0.056494746,0.069752686,0.037826043,-0.005963946,0.056180276,-0.019512355,-0.025575269,-0.010455236,0.01360503,-0.046056423,0.030024694,0.038832124,-0.014852507,0.036352664,0.048442785,0.029496348,-0.06988128,-0.061560888,0.05148544,0.055762008,0.03193596,0.04513347,-0.07169794,0.0095385555,-0.048045482,-0.052460596,0.06495682,0.028171528,0.027651368,-0.027061358,0.018017923,-0.04363139,0.020242639,0.06700296,-0.036507897,-0.05816385,-0.03950269,0.0015010609,-0.067472644,0.052234698,0.10609571,0.016854366,-0.0058725923,0.025490033,-0.06861082,-0.015295777,-0.011914193,-0.052098483,0.038463224,-0.10144511,-0.043770064,-0.031275213,0.010880056,-0.0075937705,-0.05118307,0.04794078,-0.009918692,-0.0067294016,0.012424242,-0.02847745,0.023730095,0.064697474,-0.021898694,0.07528509,0.06602369,0.025169924,0.007648241,0.048306644,0.0539658,0.008736265,0.08187024,0.024775902,-0.02713477,-0.055563927,-0.08549834,0.05688957,0.040128175,-0.010825539,-0.03393088,-0.02214195,-0.002822612,0.05700526,-0.036025137,-0.060251143,-0.07306157,0.04891064,-0.054425597,0.0070038796,-0.08623933,0.02387273,0.026329137,0.041270602,0.01733441,-0.030404035,0.0066694315,0.104490876,0.041030467,-0.103983015,-0.032264724,0.0002713201,-0.02076882,-0.045310363,-0.009076676,0.032228008,-0.04270529,0.075816646,-0.019294577,3.8793334e-34,0.012303197,0.0671644,-0.013705342,-0.044182736,0.09290841,-0.026975362,-0.13103482,0.04242074,-0.048794873,-0.06759372,-0.12940283,0.031044886,0.006537653,-0.027376235,0.08724943,0.016977318,-0.004935471,0.017345268,0.07278476,-0.09992266,0.023167603,0.018153006,-0.06441277,-0.03759447,-0.035389856,0.09933843,0.038095858,0.01668698,0.008184178,-0.046895042,0.0241162,-0.03386534,-0.020094704,-0.019878872,-0.009319764,0.027733488,-0.058515612,0.007851264,0.03138175,0.07974947,0.047484607,0.025561795,0.03592255,0.012648503,0.059502296,-0.034760214,-0.123921424,0.0288162,0.054570477,-0.020902872,-0.005244281,0.0098643415,0.104638435,0.07825107,-0.046787992,0.059758242,0.047850143,-0.032616835,0.029394893,0.0212282,-0.048703752,0.025196856,-0.060071636,0.01997658,0.009095274,-0.004781446,-0.08140382,0.042323556,0.0037692694,0.09495991,-0.052214924,-0.014191255,0.011035874,0.049046997,0.071743645,-0.042070895,-0.057600964,0.035586413,0.013002239,0.029675694,0.01635527,-0.05864237,-0.012123396,0.06363322,-0.0096236225,-0.0652323,-0.043135736,0.034845687,0.04064808,0.027867535,0.01081459,-0.0007243718,-0.032128096,-0.06578407,-0.010886963,-1.9368791e-33,0.11954155,-0.027516877,0.061834317,-0.073764525,-0.0132746855,0.014789544,-0.09630587,-0.015541865,-0.017160608,0.027044239,0.021137232,-0.02555318,-0.0007762371,0.017984558,0.030914472,-0.045784533,0.05033845,0.15405414,-0.031552024,-0.022909177,-0.072109714,0.015877195,-0.02330174,-0.015845349,0.016590556,-0.043293417,0.060782183,0.04913437,0.014488943,0.0077354284,0.023209188,-0.0005667112,-0.053029478,0.00740686,0.0016259431,0.06252155,-0.045158807,0.0041627483,0.03656965,0.10976574,0.05611638,-0.02108601,0.0058684023,0.07949622,0.046223693,-0.0035429315,-0.13915959,-0.036405794,-0.07431132,-0.034136593,0.09349848,0.07864293,0.007850243,0.010010296,0.100092664,0.06720845,0.035663206,-0.12391715,-0.0024136151,-0.023335418,0.0048454204,-0.025129087,-0.045735788,-0.015794225,-0.06745841,-0.00926722,-0.04418476,0.14074798,-0.00586181,0.011464279,-0.03526585,0.00089099637,0.06004889,0.040337134,-0.10576691,-0.0131346965,-0.011126993,0.03534083,0.078015156,-0.036616568,0.026317459,-0.007079175,0.08335643,-0.06179551,-0.056709573,-0.037907366,-0.013645332,0.10528388,0.049441148,0.009319161,-0.007027617,0.020813745,-0.04226323,0.078450434,0.09206991,-2.2628678e-08,-0.0009170959,-0.060910877,0.048932716,-0.002314906,-0.04879453,-0.025560036,0.015830677,0.0027916208,-0.0112192575,-0.09644295,-0.021628963,0.07101696,0.015067358,0.028913518,-0.018317956,0.072764516,0.0033649264,-0.01721022,0.029519213,0.10353099,-0.07062836,0.076810695,-0.035022877,0.010602494,-0.007749505,-0.01193002,-0.016900906,0.014176766,-0.029189114,0.046097588,0.059906203,0.026673738,0.04396687,-0.022016596,-0.014686648,-0.01277745,0.011701558,-0.102021925,-0.01289754,-0.06255955,0.02486891,-0.016942492,-0.07345846,-0.016405024,0.028072838,-0.02080961,0.010222043,0.02750297,0.05698216,0.012838025,-0.008255105,0.03217303,0.0100971935,-0.10005524,-0.06176028,-0.05331999,-0.062466327,-0.042014115,-0.07087792,-0.08352235,0.03139088,-0.010828149,0.14740738,0.030828927 +1.5.4.1,"In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.",384,1.0,0.0009837465,-0.010872071,-0.06963038,-0.037261914,0.00043029437,0.052156758,0.0552846,0.02994287,-0.00027598502,0.040025204,-0.0044294316,-0.0062726634,-0.118082084,0.022551168,-0.05029454,0.10440118,-0.12854774,-0.019586716,-0.04049314,-0.006166107,-0.021956986,-0.01649438,0.053497937,0.022358684,0.018357478,0.057666913,0.030258322,0.044827435,0.059628595,-0.06985471,-0.041897856,0.05231444,-0.041441925,-0.008554264,-0.04462595,-0.03323725,-0.054336257,0.02940775,0.034763034,0.046030425,0.057246637,0.011141093,-0.110448904,0.017103173,-0.04827833,0.015410844,0.05205357,0.07955811,0.029355122,-0.004579036,-0.0061742873,-0.015733225,-0.04215914,0.07815129,0.040704325,0.014596733,-0.0600453,-0.015498139,0.03224191,0.0076483553,0.089954615,0.026383396,-0.034449067,-0.025595605,-0.0024702104,-0.05598915,0.040247217,-0.04843776,0.12973376,-0.05048106,0.013849196,-0.020404587,-0.003084522,-0.003263332,-0.033082094,0.06236761,0.05818274,-0.025257267,-0.041016717,-0.023245908,0.057891782,-0.057741158,0.03426947,0.09912697,0.03268946,-0.017247334,-0.03978316,0.0011039367,-0.010048358,-0.007869413,0.058654055,-0.027952723,-0.060110055,-0.058086116,-0.05557091,-0.013566919,0.029511513,-0.05479589,-0.030159056,0.053087324,0.013525362,-0.060709868,-0.0677299,-0.08076926,-0.05178514,-0.046237268,0.051318467,0.0029168746,-0.031814292,-0.0132416785,-0.028126873,0.004867155,0.022176221,0.10248687,-0.053084865,-0.0046741352,-0.050441626,0.018400492,0.06442364,0.12433471,0.054776214,0.09844111,0.027025176,0.059270322,-0.053636532,-0.06828871,-0.14369972,3.692969e-33,0.027370142,0.06944985,0.024026616,-0.008800277,0.07969535,-0.018635554,-0.06408291,-0.038304,-0.061488353,-0.059987623,-0.053218126,-0.061477076,0.0040083546,0.069909185,0.00533437,-0.067509,-0.017357092,0.023556028,0.056613076,-0.085533775,-0.052436788,0.09346333,-0.11406111,0.031815797,0.014075764,0.09647413,-0.07111432,0.08288232,0.033470266,0.0034509357,-0.0005306458,0.027845547,-0.04224731,0.07382509,0.05521425,0.021190487,-0.01627189,-0.049854696,-0.04073495,0.019605938,-0.00012737728,-0.03262849,-0.07117513,0.016382748,0.02801286,-0.026638547,-0.04759882,0.09408728,0.035567522,-0.03007783,0.024271138,-0.07358159,0.061723065,-0.022906797,-0.059971415,0.00050832966,-0.048747517,-0.04303901,0.045532804,-0.027425224,0.0053068763,0.010053486,-0.030737713,0.040838357,0.025986558,-0.053239692,-0.03477407,-0.04348254,-0.07907659,-0.03377034,-0.07873327,0.056707177,0.040560126,-0.023693465,0.038522117,-0.014655336,-0.030231815,0.036507893,-0.021244116,-0.026522394,-0.021311138,-0.019021003,-0.015972314,-0.057466097,-0.06525315,0.022176797,0.0183013,-0.01643875,0.015875127,0.02879647,-0.003404861,-0.12171845,-0.061938852,-0.07443434,0.07092738,-4.3951708e-33,-0.0032478592,-0.044835445,0.02913037,0.0026065954,0.015741298,0.105998345,0.05752313,-0.032713573,-0.018337665,-0.07528755,0.0264546,0.022777835,-0.07099716,-0.0469786,0.008624863,-0.03735276,0.08913957,0.04706527,0.0731525,-0.0106791435,-0.068703815,0.012380907,-0.078142755,0.018186994,-0.042209048,0.00037335005,0.07557726,-0.007957439,0.040952697,0.03334836,-0.0090403445,-0.056246072,-0.06687052,0.0014909063,-0.0006302888,0.03445326,-0.078486584,-0.038620792,0.010381928,0.065173626,0.03318959,0.0042407173,0.03265967,-0.0010675606,0.10178413,0.0080383485,-0.029149799,0.0070089074,-0.0031163911,-0.050016418,0.076764256,-0.0081490865,-0.008167734,0.015661296,0.06433238,0.015840176,0.10988219,-0.043190304,0.10946956,0.03211783,0.007325941,-0.10944483,-0.030492254,-0.004594906,-0.008030884,0.015556873,0.011047032,0.1497726,0.10338348,-0.03927905,0.11684032,0.01717575,0.053315315,0.07043082,-0.055882193,-0.025349876,0.021158267,0.0291446,0.043556087,-0.017211376,-0.011226179,-0.03412803,0.012282433,-0.049142644,-0.004011468,-0.054747693,0.046946008,0.0837776,0.015151537,-0.031269345,0.03703042,-0.021360729,0.0234009,0.07880145,0.021207945,-4.1367002e-08,0.1394742,-0.08451862,-0.0025289075,0.017372197,0.050153065,-0.043106712,0.039387617,0.029914996,-0.032165293,-0.05975067,0.010828949,-0.014670244,0.07260276,0.02423,0.10917991,0.025008725,-0.0010412055,0.027943391,-0.019598896,-0.0154586565,-0.10640172,0.028330855,-0.07783641,-0.0105315475,-0.0095917685,-0.0043572574,-0.017717209,0.048356745,-0.035417512,0.018394092,0.07278416,0.04987902,-0.004422189,-0.054339167,-0.0777243,0.015775712,0.00093151454,-0.050213985,0.054883208,0.014378429,-0.014410015,-0.028839767,-0.009650897,0.021108678,-0.05252557,-0.038100615,0.049684364,-0.048208166,-0.043814544,0.019695679,0.020383647,0.10448983,0.013755846,-0.039616395,-0.14009811,-0.02291252,-0.001964494,-0.037026968,-0.08596783,-0.10544627,-0.03585066,0.04012959,0.07204018,0.026661655 +1.5.5.1,"An iron-sulfur flavoprotein, forming part of the mitochondrial electron-transfer system.",384,1.0,-0.0708611,0.012121681,-0.12581852,0.08457086,0.08486918,0.0039276984,0.012963645,-0.0007104151,0.03207581,-0.08322691,0.063033246,0.0251436,0.011591432,-0.06745617,-0.07885026,-0.010088507,-0.050393023,0.011706315,-0.030834375,0.04144728,-0.030717105,-0.029864075,0.058639105,-0.101259686,0.013712076,0.061224233,0.04201877,-0.029429996,-0.053318907,-0.026412899,0.03332073,0.014279558,-0.043541502,0.0010742847,-0.09005987,0.13133241,-0.011965927,-0.05329483,-0.072370596,-0.03700124,0.062164467,-0.01447213,-0.0034369808,0.01688591,0.009721014,-0.003508605,0.005831786,0.06911475,-0.00279237,0.033774763,-0.033076353,-0.047698732,-0.08267706,0.11653825,0.0084621,0.029283542,-0.013090439,-0.09006633,-0.04068063,0.03402152,-0.015235152,0.0014102295,-0.012301927,-0.017621564,0.027119426,-0.063867226,0.043265745,-0.017203059,0.025485098,-0.076136634,-0.006207905,-0.00063543126,-0.09542186,0.05322838,-0.014828092,0.062016483,-0.0132822,-0.026396193,0.09511814,0.022409102,0.0042565605,-0.0227988,0.030444147,0.12012971,0.055143848,0.014598803,-0.072968654,-0.004496136,-0.094445005,0.058642518,-0.019331887,-0.009022941,0.036993418,0.05183564,-0.065442495,0.059319906,0.05025507,0.108658955,-0.08449383,0.001501972,-0.016526313,0.017738752,0.047872074,-0.045801897,-0.030725578,-0.07472975,-0.00855113,0.077137016,-0.02581759,-0.03768573,0.032953322,-0.06360663,-0.010138773,-0.038123634,0.064502604,0.108449936,0.0100715775,-0.007943802,-0.031178592,0.028446445,0.012306083,0.1317293,0.022128882,0.05317003,0.01728964,-0.015312628,-0.12191714,-2.1842356e-33,0.050354082,0.072702035,0.05502371,0.0492499,-0.07159755,-0.008912495,-0.071847886,-0.01712779,0.028135618,-0.013823227,-0.10982043,-0.0047626933,0.037840683,-0.05450757,0.016215062,-0.046521112,-0.051098015,-0.012412411,0.14393935,-0.059011206,0.016933635,0.04893926,0.04076536,-0.060468007,0.026318133,0.018564349,-0.06724667,-0.020821717,0.0023801343,0.024718806,0.022870727,-0.0773286,-0.1010483,-0.009799673,-0.016106967,0.007541602,-0.0506149,-0.09208836,-0.094748445,0.03304253,-0.019975286,-0.028629318,-0.026583249,-0.029764313,0.013764534,-0.04648134,-0.06920018,0.005062096,0.012812525,0.066892356,0.002463546,-0.07865777,0.12898792,0.078840345,-0.11883406,0.043929614,0.007891609,0.01997326,-0.016296534,0.021103384,0.05435227,0.06013114,0.052960724,0.065278746,0.04545534,0.0088920295,-0.037197735,-0.023965364,-0.03616305,0.06500329,0.02519416,-0.0030928983,0.09488869,-0.012047513,0.044784673,0.021766873,-0.10404644,-0.009983663,-0.008297043,0.013885476,-0.027381033,-0.045842193,-0.022756882,0.018200662,-0.045090813,0.068545274,-0.008895604,0.008185213,-0.0035699343,-0.057196256,0.060463898,-0.0063028797,-0.028638478,-0.066234425,-0.007792422,1.07085735e-33,0.005561831,-0.074857436,-0.017826552,-0.013232097,0.004443336,0.024341073,0.02101758,-0.054578193,-0.021035468,0.06373872,0.065354995,-0.05060676,-0.022855382,-0.0739945,0.07558269,0.009669667,-0.03645363,0.0400664,0.08400013,-0.009709656,-0.02491805,0.012058125,0.031562462,0.07964235,0.036820814,-0.06189216,0.028469708,-0.08538515,0.07057073,0.027278805,-0.04160931,0.011271225,0.0052263504,-0.054769743,0.005378606,-0.003114574,1.3079463e-06,0.045094565,0.0714887,0.031062718,-0.005201149,-0.022014404,0.050214585,0.05258273,0.09160055,0.05017945,-0.07039032,0.07435487,0.047415167,0.007486179,0.057093136,0.037598807,-0.07223733,0.05389624,0.036684494,0.075187854,0.05304835,0.07855322,0.054044977,-0.029198958,-0.08968265,-0.09492228,0.013108315,-0.043679222,0.03822226,0.09666607,0.011389716,0.036666434,-0.010983955,-0.039567772,0.07128823,-0.016035097,0.021478746,-0.00229825,0.02113068,-0.05218526,0.038266223,0.08938462,-0.01316584,-0.01776932,-0.019783707,-0.033904485,0.027403042,-0.05092977,0.027052226,-0.18168354,0.0073047588,0.044015784,0.0019088357,-0.035471607,-0.01273591,-0.027839756,-0.04270028,-0.029360732,-0.080159664,-2.0740512e-08,-0.011453666,-0.004187626,0.022191301,0.030935656,0.059263535,0.06555344,-0.0049238154,-0.0385537,-0.026890848,0.0049665635,0.028647501,0.12692292,0.020873683,-0.011737078,0.02395461,0.00056262885,0.0009875208,0.039642118,0.0017758498,-0.026413424,0.014884098,-0.02599452,-0.06927055,0.034248307,0.03075321,-0.026090195,-0.013376767,-0.039321553,0.08428193,-0.10776109,0.016804565,0.034343798,0.012967215,-0.015779862,-0.09325978,0.018303001,0.0064943763,-0.032748755,-0.015383373,0.08054131,-0.10270454,-0.013322277,-0.02757143,0.007695474,0.02705211,0.02537776,0.0348929,0.018512527,-0.027381478,0.01803364,0.0041548875,-0.0027524752,0.045678634,-0.059764646,-0.075865716,0.048648346,0.0521438,-0.07388346,0.047400292,-0.04943529,0.042963672,0.018450124,0.070432566,0.034547802 +1.5.7.1,"An iron-sulfur flavoprotein that also contains zinc. The enzyme from Clostridium formicoaceticum catalyses the reduction of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or FADH2 with 5,10-methylenetetrahydrofolate. However, unlike EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); or EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H], there is no activity with either NADH or NADP+.",384,0.99999994,-0.027328413,0.002110934,-0.08316733,0.016944222,0.13955428,0.03218124,-0.044703364,0.002449321,-0.008673022,-0.06855492,-0.01991041,0.040647827,0.036142178,-0.002412954,-0.055938542,0.016985357,-0.02254355,0.010054647,0.04209822,0.03259277,0.024873447,-0.0009340849,0.044390995,0.0068238582,-0.004064854,0.029839493,0.017622214,0.011240727,-0.053458244,-0.033759456,-0.05551826,0.0025728666,0.03162902,-0.04861872,0.012409848,0.034524452,-0.01061963,0.022697518,-0.0118997255,0.00853983,-0.02966769,0.017109066,-0.034801137,-0.0520515,-0.019286867,-0.01236932,0.008668563,0.010958054,-0.0428845,0.02832028,-0.088304184,-0.023482516,-0.029776873,0.05402995,0.0728729,-0.038984776,-0.036247514,-0.052790828,0.0031441688,-0.028607922,-0.00048030342,-0.07360477,-0.0161628,-0.0324175,0.016267478,-0.01404923,0.020276822,-0.053685423,-0.011860817,-0.09329369,-0.06922261,-0.005461811,-0.010582167,0.026194973,-0.0134221995,0.06900157,0.03673635,-0.06691033,0.052693304,-0.013265133,0.002425525,-0.0046304953,-0.035323516,0.100276165,0.082944885,0.03513286,-0.035832755,0.0008249569,-0.037754543,0.04642208,0.042030703,0.05946592,-0.003065213,-0.028494956,-0.09021318,0.092295736,-0.017310861,0.054493826,-0.0024028628,-0.015259597,-0.010218312,0.025176076,-0.04074109,-0.092543036,-0.062410504,-0.01674061,0.019500034,0.13992502,-0.024170263,-0.01840075,-0.011647794,-0.029546058,-0.009029345,-0.028108323,0.01899134,0.06470215,0.063747995,-0.041796684,-0.121677525,-2.1873004e-05,0.02475505,0.044584714,0.06340574,0.00407998,0.01684284,0.030299827,-0.12384751,8.205325e-33,0.06600296,0.120664395,-0.026226377,0.015109104,0.03192377,0.08234244,-0.09160219,0.073706575,0.053028654,-0.044119008,-0.04550266,-0.033407576,0.046948552,-0.10078677,0.0011654098,-0.092940204,0.011430653,-0.028481776,0.027097322,-0.057713687,0.08169032,0.08418925,-0.0028143453,0.018884523,0.0397617,-0.009902632,-0.063384295,-0.016367575,-0.012050504,-0.016705863,0.030174412,-0.08666501,-0.093857765,-0.024828766,0.0850895,0.0017965466,-0.0625676,-0.053064913,-0.098127246,0.010536382,-0.049151618,0.019747151,-0.07684794,0.018432219,0.034801234,-0.10287832,-0.07319738,0.13199012,0.026058197,0.057601456,0.034596667,-0.005443297,0.10440772,-0.075308666,-0.119214416,0.07571751,0.011323633,-0.000101121645,0.018760161,0.08583723,0.06390676,0.06938397,-0.012924084,0.028385323,-0.017866118,-0.029934606,-0.051712885,-0.023830129,0.002205041,0.052849956,0.023575291,0.039358594,0.08006784,0.047010075,0.07379629,-0.04391614,-0.061360814,-0.050133485,0.06711076,-0.013527704,-0.05990452,-0.03851684,0.016054504,-0.008536532,-0.021647407,0.023270542,-0.043073058,-0.017683562,0.036018103,-0.027331192,0.03562753,-0.11386682,-0.046993695,-0.08109034,-0.03000447,-7.076921e-33,0.03918033,-0.03769841,0.039642464,-0.070143335,0.0267862,0.023156311,0.07648845,-0.026260903,-0.00044406802,-0.0696813,0.0876318,-0.0003950044,0.039604075,-0.0005560249,0.011814637,0.044879276,-0.013884804,0.030997245,0.05367426,0.004129545,-0.078416795,0.056038696,0.034208763,0.050158408,0.045931842,0.024346298,0.0115012275,0.036956757,0.12573653,0.045540173,0.005490803,0.07032272,-0.03573926,-0.07682585,-0.03621847,0.09711346,-0.1082379,0.019873362,0.023732869,0.04571149,-0.014144531,-0.029624935,-0.04920848,0.014089962,0.052629873,0.05872812,-0.12917484,0.06358698,0.056091625,-0.038485873,0.040916372,0.04386337,-0.05030601,0.027195439,0.087608084,0.014814655,0.011240672,0.009978685,0.030692339,-0.000936566,-0.030040879,-0.017010037,-0.013400566,0.05655444,0.06573303,0.043463744,0.037629027,0.049730893,0.033584367,-0.029664105,0.059601843,0.011349275,0.0346303,-0.0075720525,-0.01570396,-0.005085714,3.6794485e-05,0.079685844,-0.051193394,0.048210192,0.08465853,0.013051831,-0.022484137,-0.03892756,-0.051612012,-0.04825277,-0.02942553,0.053021383,-0.026091127,0.013065523,-0.061984137,0.02405812,0.0020822277,0.007284828,-0.0337603,-4.9700684e-08,0.042488318,-0.03690909,0.10659695,-0.041438747,0.07940466,-0.027352752,0.0047503905,-0.05349252,0.018045153,-0.008733244,-0.011570636,0.06494666,0.041659147,-0.04654534,0.025897654,-0.03350554,-0.036098227,0.04791447,-0.028553644,0.02889186,-0.07147709,0.008869868,-0.17006841,0.07192985,0.0380609,-0.047857787,-0.008490817,-0.093456924,0.044540707,-0.04580338,0.06205534,0.03165993,0.08593406,-0.035773028,-0.11996563,0.025742833,-0.023588797,0.0029924659,-0.04336367,0.073762834,-0.048384693,-0.06978843,-0.045182,0.0033694233,0.0063655446,-0.068009205,-0.027341912,0.0083157355,-0.021555701,-0.027433662,0.005549183,-0.005949679,-0.0033630696,-0.06458952,-0.027203728,0.0403597,0.05023625,-0.058213018,-0.005807708,-0.07451508,-0.01990101,-0.01849816,0.17258346,0.024188176 +1.5.8.1,Contains FAD and a [4Fe-4S] cluster.,384,1.0,0.015071582,-0.008478099,-0.08616457,0.0007538606,0.09798336,-0.012215831,-0.01316045,0.0017538479,-0.025013184,-0.054446362,0.027821764,-0.030951183,-0.034390986,0.0011444483,-0.048845902,-0.031117253,-0.03443391,-0.04323298,0.019452712,-0.048718534,-0.05653244,-0.03455991,0.03909112,-0.01827715,-0.036109187,0.048550386,0.0058375904,-0.03949171,0.02807511,-0.08420148,0.02585547,0.11937142,0.06271731,0.016125372,-0.031411897,0.07349046,0.13547991,-0.012844656,0.02595105,0.012906406,0.02096962,-0.013402933,0.104886726,0.035848875,0.010181849,-0.0033517338,-0.052919783,-0.0051763277,-0.007715792,-0.03813274,-0.010609593,-0.020555286,-0.08862081,0.13061439,-0.0013204381,0.042375986,-0.03486147,-0.053406797,0.009685811,0.05918374,0.06736647,-0.068961985,-0.0030147652,0.05150314,0.057430748,0.06878103,-0.034295235,-0.025267603,0.053121753,-0.058410775,0.05498948,0.038751557,-0.03988791,0.04290028,-0.0026211347,0.13851158,0.027593832,-0.046043836,0.09665191,0.011350542,-0.06674332,-0.0032470128,0.09787797,0.0075998,0.03250461,-0.006205549,-0.035993632,-0.13227937,-0.08763646,-0.023611104,0.0039226976,-0.0035601049,-0.03557933,-0.051510844,-0.065168135,0.066508055,0.015471641,-0.083753794,0.021704987,0.048423234,-0.01445501,0.039467722,-0.035293993,0.030356329,-0.10068055,-0.026843691,-0.01648662,0.11130113,-0.03653123,-0.005209837,-0.017746806,0.03449419,-0.014802461,-0.01563742,-0.057847895,-0.06831878,0.005474713,-0.023337433,0.009373534,0.0095107695,-0.010838592,0.039832022,0.026934177,0.016135382,0.054599807,-0.035604358,-0.16612852,-1.2264359e-33,0.04422697,0.032972787,0.042525813,-0.04596071,-0.005852141,-0.033021756,-0.0829449,-0.030435244,-0.016028648,-0.0077027143,-0.06919689,0.014899107,0.020304589,-0.05160804,0.07159896,-0.0693353,0.0012949954,0.016177585,0.056306597,-0.1458251,0.030023158,0.11184952,-0.008657367,-0.015316317,0.030734105,0.028678529,0.00048338494,-0.028569456,0.05067057,0.06609157,-0.03123646,0.009032097,-0.050390486,-0.02337865,-0.04251362,0.08163478,-0.067483574,-0.094444245,-0.078598656,-0.0043835305,0.013105871,0.025302403,-0.020038512,-0.06615237,0.076024696,-0.07389732,-0.012789758,-0.004964252,0.054128148,0.069726,-0.031430192,-0.052326456,0.049839716,0.06376168,-0.05375331,0.004797046,0.00066943635,0.021489408,0.0674587,0.094293624,0.050102144,0.03497547,-0.06702434,0.015038041,-0.02835476,0.022428242,0.038812146,-0.009570982,-0.005752038,0.13924888,0.016734853,0.02368983,0.0781829,-0.03492769,0.00898502,-0.06948013,-0.010614113,-0.04537167,-0.068221405,-0.02290116,-0.05182898,-0.058041338,-0.022250248,0.012583831,0.0016279982,0.0016448651,0.019522294,-0.06872038,0.014133919,-0.027824568,0.020065986,-0.0048012803,-0.0091315145,0.00056473195,-0.05530562,1.2848342e-33,0.02117598,-0.031262934,0.075606525,0.01667692,-0.0072020474,-0.019274995,0.05487774,0.0673597,0.02704543,0.024827596,0.07858585,0.0058392496,-0.013605969,-0.09381666,0.018539768,0.047383655,0.014250694,-0.0419754,0.09945119,0.08730439,-0.03418861,0.064569555,0.042889666,0.0730452,0.07744154,0.038223516,-0.0068326984,0.00038159094,-0.021199325,0.009122958,0.042158924,-0.07666299,-0.08518569,0.026194341,-0.08705868,-0.07102983,0.0036168874,-0.027600883,-0.020947792,-0.051492278,-0.0062987027,0.058365136,-0.027181795,0.17599063,0.022228876,-0.00836215,0.014305899,0.07933733,0.054612666,-0.027555326,-0.018299432,-0.10420868,-0.034360968,0.0071703563,-0.008598648,-0.0127869835,0.03362371,0.097087875,-0.11181534,0.018266024,0.04800008,-0.1260725,0.042028308,-0.010215943,0.12180085,-0.043593597,-0.0016981101,0.067371,-0.078202076,0.10084428,0.051039565,0.06756151,-0.0044936487,0.023387728,0.020855611,-0.0040556286,-0.031826694,-0.0036672093,-0.0019201363,0.035846915,-0.0639736,0.02969873,-0.00805775,0.01991724,0.0040940396,-0.050699156,0.055734783,0.08384118,0.043116514,0.013340446,-0.035073232,0.058542885,0.03621859,-0.018963689,-0.001578702,-1.8528711e-08,0.02204365,-0.037965074,-0.04004687,0.0007311705,0.01335257,-0.0048831813,-0.03983549,0.01971042,-0.008158995,-0.0013290875,0.030874938,0.0059264977,-0.086955704,-0.053393625,0.08885651,-0.0845633,-0.06889218,0.0523128,-0.0674594,-0.0048002778,-0.06351298,0.027776822,0.028561182,0.009874264,0.016117916,0.022735745,0.04254977,-0.06577829,0.025543539,0.013012265,-0.0031513106,-0.024330411,0.022832679,-0.040599857,-0.06913769,0.043979518,0.01671396,0.028782072,-0.03254355,0.06309555,0.014421194,0.0040927725,-0.045283824,0.027618557,-0.067769065,0.016278792,-0.03349443,-0.012740118,-0.015310474,-0.02344133,0.024153532,-0.046638124,-0.032628678,0.0028036921,-0.08517715,-0.031985268,-0.08166103,-0.029075257,0.04923819,-0.018743446,0.09175442,-0.05351747,0.080600105,0.053546514 +1.5.8.2,"A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors; phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. Contains FAD and a [4Fe-4S] 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+1.5.99.1,A flavoprotein 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flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.5.99.3,The product reacts with water to form (S)-2-amino-6-oxohexanoate.,384,0.99999994,-0.04646493,-0.07063011,-0.039532226,0.009482906,0.09774043,0.09470344,0.046996396,0.05771462,0.0033062152,0.01570779,0.013340964,-0.06882771,-0.056663282,0.01844871,-0.07587896,0.10651133,-0.03035286,-0.016657483,-0.0008864691,0.017098052,0.071723185,0.007135536,0.03362834,0.04138798,0.037275612,0.07878917,0.10518768,0.029560646,0.0049098236,-0.027000964,0.055014443,-0.035165954,0.061991755,-0.08693476,0.0117190005,0.04780174,0.0054753525,-0.10187277,-0.011719255,-0.039841793,0.026370844,-0.049494594,0.017621266,-0.07128943,0.058757316,-0.023759289,0.05291203,0.046023592,0.029180406,0.023834677,0.0012622144,-0.12026285,-0.09180185,-0.002723958,-0.021395238,-0.0056467745,-0.07169057,-0.022079872,-0.005042619,0.008389207,0.05469327,0.028889727,-0.048399746,0.040698763,0.049886342,-0.039208356,-0.039227493,-0.015320434,-0.004647921,-0.030998835,-0.025027374,-0.049702905,0.0708178,0.02480232,-0.047424354,-0.032156017,0.006784259,-0.08073013,0.11493807,0.006646256,0.028723361,0.012144493,0.0092298305,0.1154795,0.030233413,0.070588335,-0.018260017,-0.06385449,0.013364259,-0.047160782,-0.024525715,-0.009740457,-0.023743222,-0.06461725,-0.057366088,0.062475868,0.030742686,0.0676278,0.04994434,0.067656174,-0.03664271,0.07087313,-0.055587724,-0.16613878,0.010812656,0.005065962,-0.057769682,0.06105769,0.026732033,0.03195186,-0.04929274,-0.07177978,-0.0245689,0.06285523,-0.0385362,0.09385786,0.019263072,-0.0092373,-0.07126604,0.0021415313,0.013189256,0.032363962,0.03440719,0.0748323,-0.06419067,-0.03738803,0.008518683,-3.7592688e-33,0.051406078,-0.072884135,0.020755962,0.061385237,0.015722688,-0.059557356,-0.04975279,-0.06225113,0.01106369,0.012848239,-0.13784559,-0.040974095,0.03343091,0.039048977,-0.026042288,-0.0515221,-0.002194494,-0.005490537,0.0408051,-0.008008609,0.00081347005,0.072387874,-0.014884851,0.020659713,-0.018277768,-0.07729718,-0.005912706,-0.018076943,0.061701786,-0.01799472,0.016339192,0.01433304,-0.049696743,-0.07682922,-0.023313481,-0.036118142,-0.047460333,-0.08186817,0.05273529,0.037403718,0.041647065,0.0097210985,-0.05337312,0.029267734,0.072691366,-0.019704733,0.0013265597,0.08528595,0.12880422,0.0010984292,0.021025443,-0.05717721,0.053821154,0.04773665,-0.04613207,-0.03713246,-0.027434358,0.009444463,0.07685047,0.06238833,-0.09370997,0.06773264,-0.008907629,0.032557048,-0.038589314,-0.037732337,0.0035163735,-0.006258675,-0.005392867,-0.0004163028,-0.048162185,0.019992433,0.07225842,0.017516145,0.013622208,-0.11191384,0.00826237,0.021291919,0.022795666,0.021820258,0.053841002,-0.051420677,-0.011042917,0.0481942,-0.055135626,0.025363566,-0.042837456,-0.041985795,-0.025200281,0.10189591,0.11090437,-0.06082931,-0.06505415,-0.018871864,0.044385694,1.633223e-33,0.05446289,-0.14436686,-0.064781494,-0.022043435,-0.03786263,0.022105709,0.033641547,-0.00023479169,0.019692283,0.019039705,0.06252588,-0.0017404741,0.04206604,-0.052357547,-0.031390518,0.011084013,0.015673315,0.07977459,0.06824102,-0.021386446,0.041622765,0.020743933,0.0024589554,-0.0072334805,0.07480973,0.010502133,0.053004935,-0.015275797,0.06690847,0.056419376,-0.037869606,-0.083193436,-0.012887555,-0.015302853,0.012341245,0.045028616,0.010103523,-0.0432075,-0.05720353,0.00848176,-0.027355334,0.00660369,-0.004719784,0.07672574,0.09202424,0.05790954,-0.04238496,-0.02566561,-0.053464085,-0.06457874,0.076302,-0.05707007,-0.09677856,0.015253434,0.017127642,0.020539785,-0.008506279,-0.08007524,-0.023601225,0.005526198,-0.008394785,-0.05786602,0.03547475,-0.07182001,0.0013106852,0.08519056,-0.03968478,0.06558351,0.029657004,-0.020413369,0.08626595,-0.02169909,0.03156518,-0.026449943,0.04350494,-0.10829771,-0.026226476,-0.011073939,-0.018049952,-0.091192365,-0.039530963,0.056054354,-0.011984848,0.0077618877,-0.01109628,-0.028015476,0.037694357,0.087018706,-0.01873187,0.09165553,-0.00041839917,0.0028524888,-0.0653689,0.06516541,0.091506176,-2.620403e-08,-0.033603117,-0.11133642,0.1039808,-0.0014601166,0.0047919117,0.086185835,0.087799706,0.00902016,-0.012138689,-0.1053022,-0.016942687,0.07449669,-0.020170871,-0.01659107,0.011442847,-0.0048992825,-0.0061903587,0.040735766,-0.07973744,-0.024687622,-0.059918545,0.00075829896,-0.010386878,-0.030625025,-0.020854512,-0.032959864,0.016743954,0.06856512,-0.047842342,-0.060947977,0.0056214035,-0.0047642286,-0.053216863,-0.012447189,-0.018128568,0.007660225,-0.004031575,-0.02446495,-0.059335865,-0.02124397,-0.07948395,-0.0014837687,-0.014482926,-0.0007506712,0.059399687,0.022954248,0.00455649,0.010342751,-0.01487701,0.021468265,0.09090174,-0.048766147,-0.0068868194,-0.030766929,-0.088947035,-0.0026332862,0.0049094954,-0.099931546,-0.0024203658,-0.019417735,0.016503442,-0.015173018,0.18129802,0.04633853 +1.5.99.4,"A metalloprotein (FMN). The enzyme can act on both the naturally found (S)-enantiomer and the synthetic (R)-enantiomer of nicotine, with retention of configuration in both cases [4].",384,0.99999994,-0.043290414,-0.0260017,-0.06546802,0.02403238,0.042955343,0.077627786,0.037703834,0.066879794,0.023796163,-0.037476566,0.031113114,-0.028790135,-0.09130247,0.037373714,0.037899166,0.018861312,-0.036234766,0.074665725,-0.011848158,-0.023158636,0.025228098,0.021824246,-0.0039583137,0.006036028,-0.04767273,0.04495192,-0.02495537,-0.015510463,-0.010890487,-0.027039597,0.0075954394,0.0012124229,-0.00034831685,0.029946052,0.018408112,-0.016975207,-0.091187656,0.030338138,0.017740542,-0.041814063,0.05472382,0.013007939,-0.060386892,-0.031964373,-0.020063754,-0.021251082,0.022892173,0.01401416,-0.0051983455,0.11085706,-0.032750852,-0.08869633,-0.0112830205,0.09647154,0.052966647,-0.0102583915,-0.096395336,-0.009751097,-0.010304281,0.037423406,0.121417604,0.017882211,-0.013861412,0.0030324166,0.11408061,-0.053325117,0.010594347,-0.023623496,0.029276812,-0.031798393,0.014347361,-0.103188135,-0.052278798,-0.007896288,-0.008729447,0.023024352,-0.040032882,-0.012021957,0.07179657,0.02108371,0.053373087,0.061875746,0.024822885,0.068126105,0.028797036,0.012105687,0.011050706,0.020690322,0.04174444,0.017450875,-0.004895966,0.026652228,-0.056707237,-0.049543686,-0.088669695,-0.008864255,0.0037269683,0.07068136,-0.010221268,0.044753898,0.06480621,0.050802324,0.007855084,-0.04570921,-0.024976395,0.031423952,-0.0041524065,-0.030251397,0.051090352,-0.008410585,-0.031443175,0.027133025,0.045615666,-0.023174891,-0.009154558,0.09210147,-0.022839863,-0.0006003571,0.047563117,0.0041239276,-0.04215764,0.004223198,0.00078301376,0.06954137,0.030553844,0.040668342,-0.15163773,-1.666158e-33,-0.006361091,0.003237384,0.10721618,0.06268084,0.03275924,-0.017691923,0.043571156,0.056327883,-0.016321395,-0.010133233,-0.09895909,-0.03211066,0.0050612804,0.048471887,0.019210247,-0.066472486,-0.063972674,-0.04913684,0.06939358,-0.05542728,0.037120212,0.06267108,-0.048599873,0.02829816,-0.11806284,0.04951197,-0.073940665,-0.035555024,0.039522372,-0.010837099,0.044391982,0.0038752377,-0.053111933,-0.013689413,0.08058099,-0.04555462,0.06658964,0.009644373,-0.067289315,0.020302225,0.034150504,0.003318928,-0.022974594,0.012537211,0.05076298,-0.09139428,-0.15783033,0.039970152,0.073135205,0.045922678,0.06394681,-0.10630669,0.07124004,-0.0836116,-0.058832493,0.078265466,-0.043415144,0.053251993,-0.06181413,0.04884063,-0.031827774,-0.023739105,0.005054648,0.05778195,0.056071714,0.019700537,-0.03031044,-0.13676563,0.009682602,0.033234574,-0.04808962,0.025034742,0.072031714,0.005162801,0.023839323,-0.06847919,-0.09227404,0.011574174,-0.014945569,0.044166468,-0.027132092,-0.06622557,-0.1064346,-0.019205762,-0.05306695,-0.10742531,0.014094164,-0.10673349,0.048470747,0.03415449,-0.017579243,0.0005651942,-0.051147085,0.06973949,0.001795708,-5.9086733e-34,0.023249434,-0.09096415,0.093056604,0.016306138,-0.031796582,0.101104505,-0.033067144,-0.056937218,-0.0014127472,0.063634396,0.048202742,-0.053975545,0.13619849,-0.009007229,-0.014406528,0.04787931,-0.0383327,0.05795257,0.008744696,0.034448545,-0.10137508,0.026065193,0.0034072432,0.06966235,0.0003803906,0.048740935,0.017939638,0.084994905,0.06553175,0.04117627,-0.038320187,0.02030514,-0.050905433,-0.07044501,-0.015142895,0.07102823,0.031948965,-0.03140159,-0.060818605,-0.019516706,-0.037285272,-0.0046331887,0.0052791936,0.13040991,0.04517888,-0.0070735547,-0.032804057,0.011374016,-0.032258958,0.017417701,0.07301735,-0.05504303,-0.109475605,0.027381461,0.028240502,0.050808836,-0.04362564,-0.016717667,-0.035552576,0.0079594795,0.012229836,-0.03964583,-0.050017748,-0.038715478,0.0119653,0.012458566,-0.011491941,0.06285265,0.052196864,-0.07744646,0.097565,0.019621208,0.072836645,0.015955264,0.0011239923,-0.051476415,-0.008832468,-0.09152357,-0.034751553,-0.07506079,-0.046936918,0.017345518,-0.019271247,-0.07542125,-0.00054458977,-0.008143357,0.0132389935,0.0847521,-0.028987357,-0.011964508,0.0069418517,-0.03818448,-0.08816688,0.06678639,-0.0044607525,-3.7293482e-08,0.040937617,-0.10708705,0.037577324,-0.06756774,-0.016193286,0.055175554,0.07081663,-0.036790144,-0.03806448,-0.010389215,0.009639953,0.07377965,-0.0046403785,0.010692973,0.062914625,0.0025873962,0.008395942,0.06938583,-0.052460063,0.021701675,-0.08130913,0.03691133,0.02672078,-0.060826354,-0.010476117,-0.035890326,-0.010166224,0.06266244,0.0056201927,0.038337454,0.03528773,0.013255357,0.029084284,-0.028197052,-0.108748905,-0.025768356,-0.02921907,-0.04304507,-0.05947477,-0.026761413,-0.016495677,-0.045149263,-0.09398211,0.00079992897,-0.06387256,-0.07008717,-0.014938418,0.033481248,0.039656915,0.0025539456,-0.004826472,-0.0051015276,-0.041125372,-0.061180554,-0.11920841,-0.025516273,0.013924165,0.028992562,-0.007152087,-0.07008522,-0.0071974467,0.0070219906,0.13591707,0.009566682 +1.5.99.5,"A number of N-methyl-substituted amino acids can act as donor; 2,6-dichloroindophenol is the best acceptor.",384,0.99999994,-0.04992979,-0.06961548,-0.035704494,-0.11154445,0.047371194,0.053886812,0.03402961,0.0954856,0.07244987,-0.02413507,0.015552236,-0.008851259,-0.116818346,0.042353258,0.025567224,0.13539779,-0.021600181,0.017904604,-0.07556816,-0.0098854825,-0.04014223,-0.010326623,-0.027819114,-0.071558766,-0.009454645,0.033141688,0.044442825,-0.043830164,0.06996448,-0.013219879,0.0026450255,-0.008273576,-0.0021697218,0.041358616,-0.027443467,0.064655006,-0.045232948,-0.06287719,-0.025242232,0.053166453,-0.006466615,0.02020251,0.031709503,-0.03722246,-0.0402253,-0.07022034,0.038620915,0.034392282,0.08769876,-0.028937222,0.06659678,0.002849954,-0.03717152,0.07221772,-0.038185365,0.11272464,-0.08137795,-0.046283357,-0.052772686,-0.011178875,-0.017740674,0.03108522,0.013599168,-0.06848855,-0.013936177,0.024111027,0.00700598,-0.07140929,0.052856077,-0.041625656,-0.00053323276,-0.0061153737,0.031670485,-0.01824917,0.030507976,-0.0051232125,0.010300104,-0.0021350104,0.0581658,-0.0709544,-0.0075403657,0.009439461,0.012870722,0.07014486,0.100064196,0.023408331,-0.0708764,0.06546063,0.025386855,0.08037928,-0.0049852263,0.03887224,0.09471776,-0.046813153,-0.11334797,0.047201686,-1.0634605e-05,0.02616145,0.028991587,0.07502713,0.018297056,0.066226,-0.08983313,-0.0931314,-0.06544738,0.010013352,-0.016887944,0.009708866,-0.028493593,-0.041627068,-0.0030828589,-0.010662355,0.06687585,0.04792981,-0.032988857,0.024227997,-0.01278244,-0.052524865,0.010672606,-0.055702407,-0.02434086,0.009435045,0.081210636,0.02011518,-0.09972517,0.05123515,-0.034013875,1.18254805e-33,-0.0039319624,0.017042203,0.08342743,0.05195384,-0.02638763,0.0650905,-0.041564975,-0.003115794,0.04316223,-0.16687547,-0.09423649,-0.07314476,0.036481358,0.024198996,-0.010397629,-0.038184974,-0.027431477,0.06435763,0.054393396,-0.014643206,0.01712513,0.056487087,-0.027918842,-0.004046792,0.04293069,0.0020910644,-0.018202467,0.017553423,0.092769764,-0.009043755,-0.03502149,-0.026940653,-0.0036318037,0.00069265853,-0.062206935,-0.0042810044,0.018180707,-0.011931541,0.043344073,-0.015935075,0.0059746094,0.046555694,-0.0221586,0.04753835,0.1110866,0.039898112,0.011794481,-0.02814395,-0.10636988,0.014065875,-0.05074799,-0.055127077,0.0034862023,-0.07018197,-0.032862216,-0.061470583,-0.002736301,0.021257559,0.017066903,0.05835949,-0.009565107,0.06910925,0.022002934,0.007253886,0.002278211,-0.04339525,-0.010651589,-0.06955195,-0.0408138,0.046581358,-0.04038141,-0.032088537,0.03148965,0.085468076,0.027121074,-0.1324969,0.00042205155,0.008451485,0.038782388,0.007036442,-0.0010111771,0.026761733,0.022080647,0.0073096333,-0.06521221,0.03298764,0.012470427,-0.16290453,0.017123073,-0.023840573,0.043818794,-0.08843174,-0.069264084,-0.081296146,0.046740666,-1.0802459e-33,0.054687455,-0.12506561,0.04370773,0.07491718,0.039338842,0.0033507862,0.036379166,-0.07516332,0.10395764,-0.010346583,0.08891389,0.011152298,0.07546006,-0.036250323,0.03563379,-0.024854476,-0.04392751,0.045283712,0.011103241,-0.034783054,0.0023199143,0.053634122,0.0106981965,0.029299174,0.001141598,0.033902206,-0.07382001,0.013904055,0.123318315,0.029698322,-0.047429085,0.05414563,-0.021327203,-0.024599122,0.052639987,0.051793426,0.008069676,-0.02673712,-0.06021743,0.05643758,-0.03743113,-0.022573663,0.032395218,0.070933186,-0.07684915,0.011180159,-0.0102323275,-0.035053197,0.007623553,-0.057344414,0.043311853,-0.04999601,-0.058772292,0.020410363,0.06632151,0.0284882,0.06069274,-0.043831624,0.02076181,-0.020065099,-0.082525186,-0.041019708,0.043090224,-0.018209409,-0.010891845,-0.012592777,-0.007768864,0.1251303,-0.004443191,-0.07305651,0.053456016,-0.027481182,0.096896976,0.06725318,0.0015905735,-0.060674056,0.009000266,-0.0010665751,0.012544404,-0.04848248,-0.11563312,-0.02073312,0.014423341,0.020447895,0.05400509,-0.064101994,0.101546496,-0.0059294114,-0.08055365,0.061352883,-0.035721365,0.01677663,0.012455697,0.07994888,0.06538342,-3.0412945e-08,0.0015852666,-0.06465376,0.023193479,-0.026687842,-0.022207385,0.012352868,-0.069138765,0.04635287,-0.017395863,-0.009032863,-0.010666647,0.065600924,-0.005658118,0.0690599,-0.06299249,0.052125737,-0.037349906,-0.05007682,-0.039539266,-0.03953113,-0.06284801,0.06890892,-0.018085731,-0.08734499,0.01086466,0.012983678,-0.0049620993,0.03705997,0.0324319,-0.03679349,0.02294347,-0.043706305,-0.04826555,-0.02329729,0.09181658,0.0656693,0.0210396,-0.077597946,-0.040601116,0.028921688,0.034598146,-0.060633846,-0.099636406,0.04197929,0.042999145,-0.035486866,-0.019970201,0.013465192,-0.089227274,0.064050585,0.024356987,-0.055616632,0.036014464,-0.04382012,-0.07625936,0.0108352015,-0.041254006,-0.014701201,0.07158193,-0.022072539,-0.011302437,0.03309506,0.10713081,0.043352865 +1.5.99.6,"A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline.",384,0.99999994,-0.04573962,-0.11061627,-0.09731791,-0.0069136675,0.09945224,0.048628762,0.038583722,0.07413223,0.04398345,-0.034907527,0.004628592,0.01761682,-0.09408853,0.024447454,-0.07395149,0.04867145,-0.09915091,-0.010687922,-0.03877356,0.006803267,-0.084093355,-0.03823514,0.030195229,-0.026399741,-0.02155552,-0.004373096,0.004588851,-0.012916239,-0.032471534,-0.031458285,0.054910902,0.0695815,0.01189231,0.037926216,-0.036492903,0.030295499,-0.011681643,-0.009649621,-0.024916096,0.016165558,0.03710607,-0.01872987,0.006949398,0.007743474,0.013748795,-0.01318155,0.0015725683,0.052269567,0.027863804,0.015704278,0.0043145386,0.0010410105,-0.09928462,0.068844505,-0.0012596344,0.06302092,0.0028390696,-0.052314743,-0.027889889,0.016379343,-0.044336114,-0.029954202,0.039318435,-0.014035915,0.050765138,-0.031904504,-0.047507927,-0.039699357,0.059105985,-0.03592794,0.013905711,-0.024693856,-0.0045443876,0.033355065,0.019598171,0.071065545,-0.076956086,-0.02274896,0.06075492,-0.03349787,0.03325887,-0.036967557,0.084639885,0.07243469,0.08412499,-0.038730886,-0.039940856,-0.019236077,-0.040075,0.10579274,0.010465513,0.062328424,0.03492637,-0.018925702,-0.061730374,0.03444442,0.089429185,-0.05896308,-0.08144038,-0.018193794,-0.05864021,0.006385247,-0.003221228,-0.024802301,-0.099231154,-0.046014242,-0.018272024,0.0065160133,-0.05711794,-0.057985794,-0.041008882,-0.041971333,0.035400834,-0.071841925,-0.0005027847,0.0005627838,0.043642752,-0.037262395,-0.02139429,-0.03230555,-0.058564045,0.114021815,0.08946734,0.08224042,0.014663607,-0.021782935,-0.0515916,5.517472e-33,0.07238694,0.00010465916,-0.016984545,0.034684476,0.0016448307,0.025278535,-0.06225801,0.011917371,0.042423394,-0.0422205,-0.03694876,-0.030297995,0.018671127,-0.05169257,0.031604886,-0.012007275,-0.038739283,-0.013187117,0.08551614,-0.1520459,0.04956243,0.075049035,-0.0220591,0.013454703,0.033835262,-0.0065751644,-0.094682105,0.050176565,0.05596166,0.027550558,-0.008768813,-0.05206813,-0.09380115,-0.02200246,-0.023918042,-0.008886899,-0.093472295,-0.05907483,-0.07169972,0.05512604,-0.034116726,-0.07240661,-0.028989013,-0.0056702504,0.045189183,-0.027606785,-0.09805056,0.07624843,-0.046872705,0.09401532,0.036204256,-0.06439513,0.054942444,0.04121401,-0.07946012,-0.0019511504,-0.016779859,-0.028111251,0.013410463,0.025303688,0.03793483,0.11036092,-0.041746292,0.044890184,-0.03695603,-0.04217837,-0.0023560969,-0.047780756,0.00029608994,0.09753677,0.018794,-0.027515396,0.0796336,0.02591917,0.08845345,-0.0561706,-0.06656391,-0.03314768,-0.01918392,0.017915279,-0.02388524,-0.029198421,-0.002519195,0.023440363,-0.047482125,0.025035208,0.003929616,-0.05328914,0.0055594216,0.01587563,0.021224575,-0.070207514,0.008696874,0.006786264,0.067747034,-4.3735472e-33,0.032107435,-0.10181939,0.030273223,0.062871486,0.009247275,0.029049912,0.056690674,-0.0578567,0.0535164,-0.034702506,0.06765072,-0.034832425,-0.02326248,-0.0010266443,0.044583034,0.0046440945,-0.07626403,0.048515752,0.034130313,0.06723012,-0.058231607,-0.06488556,0.011799155,0.10959031,0.054046273,0.031082127,0.01591338,-0.017628819,0.05538425,0.06709302,-0.047839407,0.07057101,-0.044292476,-0.049554866,-0.046988375,-0.011808634,-0.01359592,-0.00011467231,-0.032225482,0.0341788,-0.04923091,0.015908135,-0.017776573,0.04892938,0.037462164,0.03554491,-0.0003676071,0.038566325,0.05631771,-0.024215449,0.009736693,0.045855902,-0.02317459,0.07228068,0.06915702,0.034275617,0.09691455,-0.007522531,0.03093229,0.031054676,-0.00308632,-0.13629244,0.030382324,-0.017971441,0.087174006,0.04619786,0.036172193,0.16849989,0.044648807,0.010622941,0.1451087,-0.0010664234,0.10556748,0.0855621,0.049058404,-0.02725006,0.077937044,0.07131685,0.03161796,-0.0093968855,-0.023623059,0.019428615,-0.0105750365,-0.017372837,-0.0391344,-0.13755909,0.031463917,0.013991376,-0.014550468,0.026282413,-0.0053731287,0.0755806,0.037933756,-0.005153604,0.08837947,-3.763011e-08,0.009853824,-0.037383158,0.02364677,-0.014161014,0.1004271,-0.019177437,-0.048869036,-0.04970038,-0.020630745,-0.043938145,-0.035702724,0.12286269,0.0071993596,-0.012602412,0.04898116,-0.010851644,-0.023567865,0.0022009134,-0.015176295,-0.009874687,-0.096662,0.06264251,-0.14004634,-0.040165935,-0.05562859,-0.028511167,-0.032012194,-0.01345089,0.038841978,0.045963634,0.05023651,0.00015374104,0.019456748,-0.059710305,-0.057625487,0.02443393,0.020925282,-0.09201473,-0.07917733,0.013866514,-0.051209684,-0.006881251,-0.010218103,-0.031884868,-0.004607382,-0.026724989,0.008944543,0.0070512258,-0.049858745,0.021182248,0.039757397,0.0001465901,0.045059416,-0.022117132,-0.061106034,0.014151411,0.0166257,-0.07698576,-0.04692578,-0.101293124,-0.058513593,-0.007692434,0.1165031,0.028803248 +1.5.99.8,"A flavoprotein (FAD). In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88, L-glutamate gamma-semialdehyde dehydrogenase [2]. Both activities are carried out by the same enzyme in enterobacteria [2,3].",384,1.0,-0.11554105,-0.088881604,-0.116848625,-0.033361416,0.053459466,0.022518381,-0.009593079,0.12578094,0.027816607,0.0009059506,0.04270465,0.03313658,-0.07165647,-0.01882803,-0.04463038,0.025839759,-0.055950608,-0.06387421,-0.07128962,-0.017414495,0.013779848,0.035277322,0.00899491,-0.037075605,0.009375729,-0.03313647,0.06389949,0.026260795,-0.04037811,-0.024863645,0.075896464,0.0020172799,0.06305399,0.01904638,0.010882308,0.029396566,0.0081649795,-0.04611733,0.013688209,0.006513502,0.048941933,0.022010446,-0.046109565,-0.054598544,0.07769153,-0.017724412,-0.059682894,0.034853235,0.018901728,0.03588781,0.00045208467,-0.039828274,-0.093942344,0.0659333,-0.041367877,0.049329016,0.030767169,-0.08175495,-0.024517123,0.013372754,-0.037612922,-0.028557165,0.047000136,-0.0020115704,0.05151081,-0.05761194,-0.028288348,-0.015524255,0.0666284,-0.072849885,-0.046560545,-0.050594304,-0.03553192,0.06768883,-0.006756524,0.0037849888,-0.063103884,-0.055699326,0.018581765,-0.08131429,0.08764832,-0.021078577,0.05541316,0.034057267,0.055153985,-0.044868823,0.035100766,-0.0010640409,-0.0008165266,0.073189035,0.0063275737,0.026846016,0.002770787,0.0468338,-0.11092233,0.06439302,-0.013739193,-0.073882066,-0.053841285,-0.025025632,-0.044553094,0.021683402,0.039509185,-0.048959598,-0.02491033,-0.01582422,0.0039569926,0.10724905,-0.0435519,-0.029961096,0.040888682,-0.039129592,0.013584677,-0.009082338,0.03824394,0.025815,-0.022730125,-0.046430413,0.009602219,-0.013844339,-0.033195663,0.060794935,0.055891965,0.06586679,0.008731137,0.045637414,-0.048993226,2.8057517e-33,0.05866146,-0.053169567,-0.025111089,-0.05487821,0.03262703,0.009917356,-0.13308443,-0.0039538075,0.061823227,-0.05786031,-0.07117243,-0.06527332,0.02743628,-0.043766104,0.059570275,-0.009529092,-0.051183034,-0.010453312,0.08249243,-0.024467051,0.0042549395,0.034465525,0.035863843,-0.0011896746,0.07835536,0.0022258312,-0.052140664,0.030201424,0.0009351919,0.021524493,0.028554587,-0.12579864,-0.07404093,0.051652614,-0.046025474,0.052738022,-0.03663399,-0.08839226,-0.08048492,0.075619236,-0.009343568,-0.0052548572,0.0013451483,0.013710157,0.025784988,-0.08524871,-0.0796308,0.15134087,-0.015147556,0.11314018,0.021461634,-0.02078741,0.12944336,0.012773221,-0.07369132,0.05138897,-0.023325255,0.010074585,0.10126188,0.02952617,0.034025002,0.094145276,-0.059596654,0.07911434,-0.006119452,0.009906727,-0.03818113,-0.045980733,0.008423644,0.0765374,-0.038718354,-0.017490702,0.12422969,-0.029571606,-0.013252046,-0.031301584,-0.070492744,-0.028832857,-0.006895417,0.017689846,-0.0443924,0.042778946,-0.044621356,0.024266874,-0.016659189,0.04310316,-0.03309181,-0.06747747,0.02179074,0.021013647,0.071417995,-0.008962178,-0.023479747,0.022736976,0.03435681,-2.8971963e-33,0.06058216,-0.06084303,0.036107693,0.014940498,0.010328982,0.054684136,-0.007236733,-0.007938349,0.03159353,-0.005979129,0.020840209,-0.008532924,0.0066104773,-0.029610354,0.09645446,0.008139742,-0.06252324,0.0720964,0.030886613,-0.032597926,0.013718073,0.010902775,0.076912485,0.06822612,0.045872703,-0.042690676,0.04837849,-0.012748754,-0.010094186,0.012287215,0.0130298175,0.08294316,-0.06252021,-0.06401445,-0.0542125,0.040823374,-0.0026713582,0.041497145,0.016595028,0.04619066,-0.0058445963,0.06693018,-0.0044181314,0.015629346,-0.00087909086,0.08073223,-0.022490056,0.020550715,0.053546708,-0.04110797,0.03259761,0.013090763,-0.020158427,0.004968101,0.042968553,0.05188101,0.0014720586,0.033747014,-0.058077935,-0.012155148,-0.0073953564,-0.12700555,0.0147920195,-0.021595562,0.080220886,0.036387805,0.055831723,0.043185826,0.04030406,0.011498524,0.116619214,-0.02178446,-0.060570505,0.037602972,-0.005060435,-0.022408543,-0.0059003225,0.036699995,0.0072084498,0.018999353,0.07899621,-0.04915423,0.009858434,-0.019050773,-0.061512172,-0.12127559,-0.03909144,0.121434785,0.040850904,0.043137506,-0.04461982,0.03774146,-0.019037029,-0.017247265,0.043658476,-3.8676824e-08,0.01630771,-0.03333161,0.073361956,0.012392977,0.1249933,0.016384235,-0.017889792,-0.04289922,0.05825532,-0.054066963,-0.067712784,0.12433937,-0.0627232,-0.014166887,0.020034097,0.02139656,-0.015780097,0.037250068,-0.04398775,-0.00873773,-0.06829677,-0.014021609,-0.13373643,0.03698646,-0.033908658,-0.07512725,0.011314168,0.0068483073,0.027269263,-0.02691073,-0.021799862,0.06536854,0.03827919,-0.07035093,-0.08421946,-0.03253602,0.089904845,-0.01697575,-0.050968207,0.041629024,-0.05767654,-0.049137235,-0.022590555,-0.06595554,-0.015655816,0.003143232,0.023926338,0.026028413,-0.08634259,-0.016400242,0.00010657243,-0.028961547,0.013172897,-0.0025220814,-0.10506025,0.02643443,-0.023412172,-0.09645863,-0.04355158,-0.04017919,0.052633252,0.04493907,0.158563,-0.01826387 +1.5.99.9,"Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum.",384,1.0,-0.044760566,0.010370839,-0.12373972,0.030005218,0.037254192,0.01790152,-0.09208357,0.11880773,-0.02426887,-0.0015192317,-0.013443836,-0.123091966,-0.116714306,0.010305276,-0.014008236,0.028509045,-0.033026606,-0.05310093,-0.021246165,-0.07191638,0.0043004015,0.05882652,-0.029272255,0.02728977,-0.0156278,0.0004406231,0.009442392,0.0135396505,0.02806921,0.030057786,-0.027414657,0.0036476736,0.0822408,-0.010506031,0.022283498,0.069982335,-0.007890054,-0.07685567,0.08776795,0.040880226,0.009986344,0.02657271,0.04256095,-0.005828159,-0.021398323,0.0026427943,-0.036201123,0.018413208,0.042676765,-0.058688864,0.009654508,0.025110103,-0.073175356,0.027762728,0.08111122,0.0033237743,0.00624096,-0.05031533,0.007955515,-0.029692113,0.09346242,-0.044474557,0.032256346,-0.010518838,0.04047139,-0.014699922,0.06366888,-0.09890564,0.084332675,-0.015669825,-0.06822533,0.017831529,-0.01984998,0.0022499505,-0.03289171,-0.013980024,-0.04002775,-0.057985518,0.0811258,-0.029092904,0.07845375,0.011413357,0.051388975,0.011610083,0.038651653,-0.038722046,-0.02533779,-0.03189307,0.062184215,-0.04466624,-0.049746763,-0.016281545,-0.041686952,0.02340806,-0.17356282,0.009867398,0.105689116,0.0007572215,0.021307712,0.03674322,-0.04254709,0.03598214,-0.10988743,-0.06618536,-0.09124699,-0.00040039825,0.08024782,0.096237265,0.041656107,0.03832309,-0.037061695,0.010800177,0.038087375,-0.022942659,0.022262078,0.018804096,-0.004702689,-0.0580182,0.053980302,0.073151045,0.040297672,-0.0076393774,0.039585896,0.091429956,-0.024969963,-0.023700802,-0.08989221,4.6725728e-33,0.06498427,0.06922307,0.027003815,0.04270404,0.05002198,-0.03774366,-0.0696144,0.011176521,-0.03996798,0.021339584,-0.041275524,-0.04749024,0.048296038,0.015892202,-0.05198248,-0.07589731,-0.049171537,-0.023766613,-0.0069412487,0.023921143,-0.012078902,0.08875763,-0.0008464622,0.033238243,0.060432736,0.031381667,-0.011015364,0.03568422,0.060118094,-0.005644214,-0.010337016,-0.057783183,-0.15835527,0.016093807,0.020872565,-0.025301013,-0.08576315,-0.051464126,-0.08846537,0.06263279,0.04174483,0.0019488132,-0.010034888,-0.041093726,0.077589855,-0.008434247,-0.023420935,0.091106966,0.066155046,0.043544304,-0.032847103,0.016650127,-0.025140654,-0.027161667,-0.05654933,-0.0598871,0.002628434,-0.025258325,0.025433727,0.056169134,0.010296026,0.0061231935,-0.03189964,0.05462959,-0.048748463,0.0206435,-0.030152028,-0.059380498,0.074300215,0.055748615,-0.02294666,0.03259481,0.028809402,0.08177895,0.048148446,-0.04913413,0.0021845654,-0.040572457,0.02666226,0.0141125405,-0.01266581,-0.020112189,0.026635457,-0.0026030138,-0.08719834,-0.026718944,-0.05487044,-0.06300678,0.03228594,0.052328665,-0.02530927,-0.036125395,0.0357325,0.0147043625,0.030521609,-4.249595e-33,0.02900792,-0.040266115,-0.018053317,-0.10206976,-0.043441564,0.05670197,-0.03888352,-0.044650648,0.0149941,-0.038409535,0.19238046,-0.037983872,0.052455906,-0.0014509608,0.05329005,0.065091304,-0.0181302,0.0345779,-0.014121608,-0.05565824,-0.011606341,0.016398357,-0.011529491,-0.0029949958,0.050798003,0.022069704,0.015852308,0.0006757971,0.04608208,0.08566804,-0.04929678,-0.024214141,-0.04390376,0.05354638,-0.08438207,0.046257988,-0.042933676,-0.0009026291,-0.032908175,-0.025014956,-0.024466371,0.046976577,-0.031199154,0.035676617,-0.020101428,0.012545779,-0.030801998,-0.05742514,0.0718217,0.013366046,0.023981728,-0.09000768,-0.09540162,-0.051398844,-0.07436809,0.09919153,0.03147376,0.0069274143,0.053019866,-0.003995178,0.05193048,-0.015723169,0.050900195,0.08345045,0.04654949,0.067565516,-0.053318676,0.044233844,0.086563535,0.039454095,0.079727225,0.036102585,0.04772434,0.09663465,0.022806678,-0.06821199,-0.024253564,-0.018204305,-0.07312066,0.020685583,0.0040215086,-0.029785497,0.048330694,0.0024376614,-0.064226836,-0.09959977,-0.004585223,0.029753601,-0.01688351,0.06955171,-0.028840195,-0.00227698,-0.037496455,0.016568214,0.04261442,-3.7456164e-08,0.043400504,-0.04219626,-0.017071873,-0.04313103,0.009145994,0.037177823,0.019719075,-0.100794695,0.0014437811,-0.0059497524,-0.029467104,0.07683445,0.052605763,0.037998956,-0.002539941,-0.011001517,-0.022503346,-0.018884497,-0.028167296,0.01884231,-0.06181953,-0.010127882,-0.045771778,-0.016713265,-0.023594657,-0.04764172,0.0032561598,0.15395394,0.040974308,-0.043209746,-0.0034585844,0.07498843,-0.016544802,-0.032570533,-0.08226776,0.08129062,0.012723528,-0.020443548,-0.12450607,0.044299316,-0.0064829,-0.012657328,-0.055863213,0.0154705895,0.11555486,-0.048227586,-0.015458952,0.010883084,0.018620452,-0.02587059,0.06184398,0.0054703616,0.0020350541,0.02623107,-0.05763501,-0.021993404,-0.06927716,0.0009383702,-0.028075643,-0.059046086,0.0037313527,-0.0067996774,0.17436457,-0.0786263 +1.5.99.11,Catalyses an intermediate step in methanogenesis from CO2 and H2 in bacteria.,384,0.99999994,-0.06298666,-0.011934232,-0.0674095,0.03720793,0.03907111,0.015475764,-0.068759985,0.03165803,0.007699727,0.0237293,-0.00803062,-0.0973063,-0.04518436,-0.019179355,0.031488024,0.004832091,-0.061550062,0.0116960555,0.03498583,-0.03263922,0.075439945,0.049182054,-0.06159266,-0.056686364,-0.033100083,0.061107606,0.05937386,0.0018179475,0.03690527,-0.006640934,0.038005102,-0.046823915,0.05102516,-0.057495035,0.08660166,0.050212864,0.1032796,-0.07088635,0.09509968,2.9952953e-05,-0.018284522,0.03534427,0.066646636,0.012426965,0.04568093,0.029743973,0.09061705,0.03792908,-0.0037718625,-0.15062086,-0.089546114,-0.0109926555,-0.043646723,-0.031259082,0.041336484,0.06676496,-0.016913312,-0.006928822,0.054942675,-0.07081727,0.02005326,-0.011494808,0.042074498,-0.008522393,0.010552238,-0.085366644,0.03892308,-0.039897148,0.0943814,0.026269767,-0.05914292,0.042754803,-0.024229588,-0.06386424,-0.03259486,-0.037707686,-0.018683655,-0.0672566,0.05514129,0.002063318,-0.012625671,0.027547361,0.07872818,0.0012983389,-0.02866054,-0.0352281,0.02057696,-0.005937425,0.03716103,-0.012156068,-0.07731081,-0.0385924,-0.01220501,0.014763144,-0.11752734,-0.025846194,0.17094141,0.036945608,0.07316475,0.00092583935,-0.03199695,0.04574726,-0.06644979,-0.057071224,-0.022982396,-0.05182229,0.08909176,0.1498494,0.051275026,0.07522443,0.061140988,0.019482657,0.031903654,0.012416967,-0.0006343784,0.09279206,0.030463798,-0.04979694,-0.048701443,0.0069806646,0.032226305,-0.01940369,0.011809642,0.010830907,-0.083814,-0.035977036,-0.033214167,-1.088178e-33,0.0636223,0.0045496775,-0.015415789,0.018941179,-0.016986655,-0.0496266,-0.11957753,-0.055341132,0.04355786,0.01701206,-0.0406644,-0.06073906,0.060915697,0.0038328082,-0.05287667,-0.035404857,-0.061781425,-0.033165615,0.04931526,0.023107847,-0.07352128,-0.029737657,0.021018999,0.0035608732,0.014799289,0.034229558,0.03789021,-0.028921677,0.046548545,-0.002010029,0.03816301,-0.043879848,-0.08335062,0.067892544,0.05429198,0.013436622,-0.11980562,0.00426304,-0.027004166,-0.01838511,0.035215974,0.039374214,0.003616768,-0.06680491,0.0166829,0.019699696,-0.0035754154,0.113812335,0.03693911,0.00591214,-0.032366134,0.014500501,0.06939426,-0.0019056987,-0.06346444,-0.030501852,0.027853098,-0.048390493,0.0045728786,0.043890256,-0.05138327,0.05571034,-0.007067751,0.09099263,-0.050720904,0.01960261,-0.034890734,-0.034160968,0.121654846,0.13446595,-0.05790946,0.02593939,0.009243823,0.025881244,-0.009637194,-0.043294292,0.0457901,-0.048205253,0.076993346,0.05357816,0.06613902,-0.022535808,0.041588716,-0.07532723,-0.014229696,-0.008020168,-0.11751397,-0.03206101,-0.031331554,0.063357584,-0.012846826,-0.040783737,0.03076713,-0.007104819,-0.0104795145,-1.9745387e-33,0.057560317,-0.052850474,-0.007681595,-0.12158459,-0.08977887,0.049375534,-0.050316107,-0.097838044,0.011084007,-0.0018311081,0.04932705,0.0055509843,0.05827266,0.01972421,0.0076760026,-0.04618989,-0.01010904,0.07066012,0.028464599,-0.026107585,0.0883985,0.0027477685,-0.082663305,-0.105657116,0.04740209,0.010174462,-0.042841133,0.03710938,0.005689871,0.022959542,0.051476203,-0.055378117,-0.06816896,-0.05420468,-0.06561312,0.017481137,-0.0482036,-0.020518562,0.014684947,-0.021967623,0.025831195,-0.019252192,0.02828742,0.03991131,0.049854092,0.010787424,-0.0514333,-0.011884383,-0.050889708,-0.0149486475,0.017941764,-0.05443024,-0.11619811,-0.10301953,-0.02704445,0.07930218,0.04274551,0.013360902,0.039558005,-0.04400704,-0.025595823,-0.07639132,0.02322961,0.031104714,-0.0004181169,-0.009438709,0.024431145,0.023863414,0.04844946,0.004130018,-0.010950209,0.10013609,0.00871257,-0.023653004,-0.040754776,-0.029839423,-0.09237342,-0.050284155,0.035897452,-0.0362668,-0.02933731,0.0050941748,0.03864517,-0.019669097,0.0051129633,-0.07892481,0.014487357,0.0058972766,-0.039193474,0.049474012,-0.05937518,-0.008153967,0.03433782,-0.014502009,0.009560089,-2.0370658e-08,-0.03314927,-0.034337185,0.05728346,0.04730523,0.0040812804,0.15673426,-0.008475112,0.021770116,0.07496371,-0.030042436,-0.013811015,0.06444894,0.07391501,-0.045969665,-0.023700899,0.038668312,-0.04535078,-0.08812255,-0.04109085,-0.039305132,-0.023619648,-0.056022976,-0.060052484,0.09210431,0.011148292,-0.06961773,0.037516307,0.07983026,-0.043745495,-0.115135014,0.00871801,0.012378905,0.012184819,-0.026630431,-0.051433798,-0.05851239,-0.01974697,-0.023803648,0.0017035984,-0.051035546,0.039910886,0.08513904,-0.07975579,0.040015347,0.022934739,0.043764006,-0.025468014,0.026910871,-0.054562524,-0.0061257244,0.05739735,-0.026382687,0.040321916,-0.011742102,-0.040350057,0.0396949,0.004432735,-0.005200458,-0.015766019,0.054816812,0.06193125,0.053759284,0.077813186,-0.022718279 +1.5.99.12,"A flavoprotein (FAD). Catalyses the oxidation of cytokinins, a family of N6-substituted adenine derivatives that are plant hormones, where the substituent is a prenyl group. Although this activity was previously thought to be catalysed by a hydrogen-peroxide-forming oxidase, this enzyme does not require oxygen for activity and does not form hydrogen peroxide. 2,6-Dichloroindophenol, methylene blue, nitroblue tetrazolium, phenazine methosulfate and copper(II) in the presence of imidazole can act as acceptors. This enzyme plays a part in regulating rice-grain production, with lower levels of the enzyme resulting in enhanced grain production [2].",384,1.0,-0.071361296,-0.058400422,-0.040981654,0.018202139,0.13909316,0.047281034,-0.036169913,0.015810026,0.07532338,0.029617202,0.08678837,0.03146165,-0.08417059,-0.080800384,-0.12936391,0.09392364,-0.05836638,0.06962498,-0.10641057,-0.07728489,0.0057155415,0.005813132,0.02891088,-0.030747516,0.03559495,0.015852153,-0.0030220086,0.016879048,-0.02550502,-0.042617086,0.020119628,0.041370686,0.056802478,0.0535063,-0.027234828,0.08765288,0.05466802,-0.07990774,-0.00344138,-0.074268624,0.0026878743,-0.051403027,0.030335579,-0.015442537,0.029161476,-0.0248867,0.0592261,0.022727208,0.024574231,-0.017453661,-0.013759516,-0.0033665842,-0.028367965,0.034300614,-0.0035796356,0.06845684,-0.085297525,-0.0083672255,0.0036993786,0.04093278,-0.0065630577,-0.038402863,0.020374268,-0.0022701023,-0.019423483,-0.045712717,-0.10390921,0.017683335,0.03595532,-0.05424007,0.018920472,-0.024196379,0.021469446,-0.010287303,-0.034409005,0.103002496,0.015497642,-0.02555472,0.030123366,-0.042221725,0.015775003,-0.008113879,0.14118429,0.06114578,0.06313467,-0.04186255,-0.048986856,0.03617388,0.05185556,0.06026927,-0.013456755,0.0517231,0.055110894,0.041302957,-0.021284472,0.06577286,0.052100863,-0.020039067,-0.057695176,-0.026874244,0.006015675,0.047270257,-0.07040783,-0.043144055,-0.06593046,0.02198924,-0.056439333,0.034557965,-0.024204107,-0.009831702,-0.013399827,0.014137751,-0.055014834,-0.024412636,0.009893369,0.01803612,-0.007308046,-0.061514746,-0.059644867,-0.03846848,-0.021822898,0.009390571,-0.020325894,0.022642542,-0.026898015,0.014876442,-0.079745375,4.8188888e-33,0.059637,0.050360683,-0.007421158,-0.007699919,0.016122995,-0.07534345,-0.04729232,-0.020775195,0.030990394,-0.060408816,-0.109394185,0.0008032566,-0.0057930625,-0.063300945,0.056112412,-0.046947807,-0.05844415,-0.017265137,0.13427974,0.009050025,-0.018109808,0.016953282,-0.10864754,-0.028123591,0.007573039,-0.005075879,0.025319474,-0.058403894,0.025687914,-0.004009747,0.024867753,-0.04762813,-0.042332184,-0.00088713545,-0.050982103,0.0120005505,-0.06924856,-0.027143264,-0.045902666,0.06940876,-0.070150875,0.015877612,-0.017685357,0.0021661366,0.073155336,-0.028024673,-0.029927941,0.10403891,0.020903436,0.097398944,0.058380812,-0.008586305,0.14093737,0.04391524,0.017765773,0.021451982,-0.043062694,-0.060320407,0.011844785,0.053406965,-0.03177094,0.0071550617,-0.057267565,0.06823595,-0.051791746,0.018393815,-0.07000587,-0.044120215,-0.008086741,0.13675663,-0.008359309,-0.048875485,0.02986011,0.0385611,0.04415638,0.00090598944,-0.036958862,-0.006835041,-0.029478002,0.019451817,0.046950415,-0.017059628,-0.030229688,0.01748485,-0.052412905,0.07720895,-0.124362364,-0.02761401,0.08624053,-0.011738937,0.12802215,-0.10428774,-0.024647778,0.010919408,-0.05740461,-3.2923584e-33,0.059594426,-0.061011788,-0.03374903,0.017944876,0.0037878235,-0.02064328,-1.5616633e-05,-0.049898613,0.08918453,-0.06820501,0.0106079085,-0.03929945,-0.00032231375,0.015740102,-0.012034926,-0.0043140217,-0.012383539,0.12866247,0.020684753,0.016758977,-0.068034,0.08130259,0.028351722,0.06547892,-0.01243195,0.012821277,-0.023841638,0.00052849593,-0.009463514,0.043972492,-0.01902395,-0.04840017,-0.0025179028,-0.050068386,0.0659131,0.026510568,-0.057596542,-0.050270982,-0.008178331,0.06498891,-0.0039205025,0.03298473,0.009115723,0.03128374,-0.05260623,0.07191863,-0.077036574,0.05026445,-0.010346855,-0.0056668506,0.022279682,0.04549205,-0.0062239356,0.047792155,0.07638847,0.042543627,0.08712026,0.012358002,-0.031937554,0.04645506,0.011496143,-0.08821617,0.05656553,-0.035244104,0.062439833,0.065329865,0.010970915,0.15821022,-0.008308497,0.031895135,0.051852845,-0.057403583,0.049165417,0.052304257,0.009256546,-0.020325037,0.0078102127,0.004653625,-0.041511133,0.03871808,-0.0013582362,0.0102419695,0.048257872,-0.06460223,-0.054472733,-0.0112402355,0.026145922,0.11176311,0.05739061,0.055145636,0.043989036,-0.0072162254,0.03907046,0.059687965,0.040748827,-4.8358107e-08,-0.011370322,-0.11447484,0.043058157,-0.055586442,-0.0018968254,0.045961954,0.047799673,0.008384349,0.035476107,-0.05724843,-0.0314166,0.15238515,-0.0033412543,-0.051804263,-0.026841853,-0.023504747,0.031347383,0.0104356585,-0.019842068,-0.044918053,-0.092891864,0.051632408,-0.13647793,0.0066947164,5.204772e-06,-0.010242771,-0.00213132,0.0048366706,0.05007275,0.023438852,0.038660377,0.050282847,0.04741355,-0.052747782,-0.14136064,0.029499236,0.058911964,-0.04764772,-0.06612253,-0.033569507,-0.08381436,-0.01980283,0.00889995,-0.01217913,-0.008780644,-0.020445636,0.03148504,0.02275505,0.0074896314,0.00029079744,-0.012464067,0.013132556,0.0123594105,-0.07168952,-0.05071226,-0.027668195,0.0071536507,-0.027293999,0.0045673787,-0.086881116,-0.019343313,-0.00912623,0.13025571,0.0044208723 +1.6.1.1,"The enzyme from Azotobacter vinelandii is a flavoprotein (FAD). It is Si-specific with respect to both NAD+ and NADP+. See EC 1.6.1.3, NAD(P)+ transhydrogenase, for enzymes whose stereo specificity is not known.",384,1.0,-0.06485401,-0.03176571,-0.124511525,-0.0034977433,0.044023417,0.056492865,-0.016677404,0.06486186,0.018912803,-0.009348579,0.0006354869,0.011537531,-0.04911791,0.038985543,-0.06030663,0.032803807,-0.036930792,-0.017323485,-0.03484049,-0.006766273,0.019137954,0.05707485,0.040804747,-0.061339963,0.04788967,-0.025166316,0.011988622,0.015297679,-0.026313208,-0.021825131,0.017707732,0.05005589,0.07216549,-0.081970215,0.010669695,0.04911996,-0.019381704,-0.052019067,0.020243881,0.0048403232,0.08816079,0.024529317,0.010900819,0.032274444,-0.0028786422,0.03451164,-0.0077483687,0.074129246,-0.009799029,0.048700426,-0.04196947,-0.06367308,-0.06811236,0.037761033,0.016055655,-0.003621622,0.061507016,-0.031053679,-0.017518943,0.047345217,0.028188169,-0.03739557,0.038728904,-0.0013532705,0.056843527,-0.05524995,-0.020167604,-0.046560753,0.017550059,-0.085053064,-0.07019958,-0.031353153,-0.06770446,0.048515644,0.00544388,0.026099673,-0.047845975,0.002707336,0.04252686,0.0046397476,0.018378243,0.015051885,0.0485634,0.028251756,0.053938348,-0.012786173,0.006182238,0.059202753,-0.008072946,0.046302244,-0.020447565,-0.013114794,0.028584447,-0.014812333,-0.07328326,0.025302077,0.032703724,-0.06629206,-0.016090402,-0.052259736,0.021837505,0.030604772,0.016966589,0.0017503075,-0.08602026,-0.044165626,-0.03144373,0.13494997,-0.07891775,-0.026818888,-0.00037114363,-0.017597059,0.066651225,-0.10421572,0.0016816912,0.032033637,0.031436976,-0.03392169,-0.04501837,0.010707042,-0.04292471,0.031869512,0.034875587,0.056666203,0.053967416,0.060364414,-0.16067141,1.1482044e-33,0.103332624,0.037446193,-0.046943706,-0.035847593,-0.014898486,0.037028976,-0.063752666,0.032954376,-0.030781128,-0.044437326,-0.05989968,-0.10526589,0.058478598,-0.036463805,0.0059749354,0.11637806,-0.059401616,-0.0702476,0.062524244,-0.008573519,0.060023632,0.07037001,-0.05357361,0.04243842,0.028043797,0.057266995,-0.07371331,0.027740642,-0.019771818,0.0045943246,0.026689382,-0.08587979,-0.12468478,-0.047034524,0.024517054,0.021350315,-0.07723892,-0.05925274,-0.06268169,0.03462427,-0.018756978,0.022601256,0.013848811,0.028817086,0.07198921,-0.011583235,-0.07546082,0.059106827,0.03321927,0.013467811,-0.026212107,9.087728e-05,0.13177636,-0.0014378754,-0.061791413,0.049934495,-0.021184724,0.093370534,-0.018192366,0.02213261,0.06120176,0.05150088,-0.018438423,0.13356619,-0.11286253,0.033192154,-0.037299592,-0.043460775,0.061218154,0.12543513,0.018694982,-0.0045434167,0.08354842,0.0069543817,0.042552207,-0.063985154,-0.006223291,-0.089481175,0.035982072,0.042190377,-0.09073183,-0.008890744,-0.022510445,-0.07918466,-0.073151305,-0.017789986,-0.034376957,-0.030952685,-0.007360318,0.028247334,0.071668655,-0.028037814,-0.05637682,0.023435663,0.01743775,-1.3536895e-33,0.07165745,-0.042057008,0.09841578,-0.060216624,0.0015415654,0.027937451,0.03185344,-0.05211536,-0.027884137,-0.03182813,0.061328128,-0.018457022,-0.04138758,-0.017161267,0.050550412,0.04071431,-0.02051659,-0.010246539,0.09184386,0.050643634,-0.03862912,0.023435436,-0.0048303697,-0.0061216387,0.011882894,-0.050924573,-8.680691e-05,0.0077781775,0.02905058,0.02923736,-0.040247884,0.005764432,-0.07932419,-0.059004594,-0.08709778,0.017532105,-0.02447841,-0.030744031,-0.013135435,0.044257447,0.027394563,0.016790748,-0.05442092,0.06581386,0.025164474,0.03334018,-0.083550125,0.023176169,0.040263515,-0.07156321,0.016401168,0.026636606,0.01436359,0.050770763,0.03200108,0.021758601,0.030705119,0.095862366,-0.041275803,0.026610985,0.021901896,-0.120683506,0.028252428,-0.00528192,0.058558922,0.115815215,0.08587469,0.10567814,-0.006135171,-0.028014971,0.094383106,-0.009896837,0.008221438,0.08207864,-0.019396504,-0.045894034,-0.051500607,0.08398673,-0.017209344,0.019212434,0.048271954,0.01006384,-0.048148423,0.023815151,-0.014091569,-0.015989026,-0.015304016,0.05722955,-0.018133579,0.022113627,-0.046644818,0.047128685,-0.048198186,-0.021215158,-0.0015502428,-3.6099152e-08,0.039321657,-0.051981106,0.00023404369,-0.07959383,0.038794134,0.02723061,-0.051472317,-0.04412179,0.007587442,0.0406222,-0.014148214,0.10701149,0.012344888,0.03103459,0.14313826,-0.06270952,-0.0049058706,-0.0052455715,-0.027782425,0.015593258,-0.05721875,0.041281216,-0.12108313,0.0102207195,-0.053348344,-0.033965617,-0.019513998,-0.054384317,0.07479497,-0.028619267,-0.0019279884,0.013628649,0.057169955,-0.048001442,-0.1309204,0.064154275,0.03563503,-0.12812528,-0.05198172,0.031091835,0.0070947935,-0.066885464,-0.04704704,-0.012545901,-0.0062093255,-0.0042113275,0.06976041,-0.044923943,-0.057087444,-0.0072855186,0.016226955,-0.01994758,0.014444219,0.0013828841,-0.0498316,0.031269014,0.0009203053,-0.091215685,-0.018499203,-0.023015631,0.05066077,-0.007513434,0.14411631,-0.04398456 +1.6.1.2,The enzyme from heart mitochondria is Re-specific with respect to NAD+ and Si-specific with respect to NADP+ [cf. EC 1.6.1.1 NAD(P)+ transhydrogenase (Si-specific)].,384,0.99999994,-0.018456671,0.02167312,-0.0070867864,-0.0055866917,0.033524014,0.068228036,-0.099797376,-0.0034015563,0.019674446,-0.018335141,0.0326097,0.020474982,-0.06776647,0.06373445,0.007598631,-0.04404938,-0.035057373,0.02235416,0.0014026782,0.026793877,0.026253998,0.0022142006,0.032589767,-0.053320996,0.031631216,-0.042481013,0.03760226,0.030637722,-0.037874017,-0.0165843,-0.03697961,0.063318424,0.008864767,0.0041396148,0.0027312369,0.07010665,-0.07563118,-0.009957616,-0.07334557,0.020452831,0.04624912,-0.033599555,-0.048787296,0.045527622,0.019305857,-0.044923745,-0.02222303,0.023176786,-0.012767801,0.06698147,-0.03430137,0.0016973309,-0.0810219,0.0147384275,0.045311775,0.007517318,-0.0006918686,-0.03869133,-0.019855618,-0.012325714,0.009963227,-0.05127903,-0.037002794,0.016495863,0.07965469,-0.032148886,0.08379757,-0.04369304,-0.01907654,-0.053789306,0.008369616,-0.04105315,0.027817035,0.031291425,0.0025481589,0.022358224,-0.07669816,-0.0365242,0.03975455,-0.014537526,-0.018221883,0.052246112,-0.06017491,0.026089536,0.09238032,0.058213066,-0.031270273,0.032825045,-0.024081737,0.0010128771,-0.0096475575,-0.07549251,-0.011032852,0.040151004,-0.07241195,0.019278033,0.031368505,0.04347005,0.03297631,-0.089491755,0.05558019,0.112099774,-0.046929553,-0.024668949,-0.021926997,-0.023671547,0.0065426277,0.12905036,-0.05579826,0.03138641,0.048397493,0.011199757,0.08277553,-0.07380678,0.0315791,0.120922916,0.01914973,-0.029946953,-0.064833,0.053457204,-0.021596806,-0.037414845,0.005644318,-0.025240073,-0.045966502,0.08315137,-0.12954785,-2.132029e-33,0.06908174,0.0047988696,0.030933898,0.032444954,0.017259149,0.022014052,-0.08053704,-0.034415983,-0.059148666,-0.030340014,-0.024019238,-0.019706015,-0.009137422,-0.01629203,-0.0046073846,0.025024291,-0.044349488,-0.05094164,0.043113686,-0.04882262,0.01093509,0.101375416,-0.059790727,-0.05257791,0.011368131,0.047623783,-0.027384004,0.06245609,-0.0016811836,-0.013182323,0.02257158,-0.10368841,-0.08488577,-0.015068581,0.021628134,-0.006107455,-0.031702362,-0.03617349,-0.016960915,0.030437034,-0.021812724,0.043617368,0.0013370649,-0.07027584,0.07678904,-0.11053474,0.0050143595,0.010564694,-0.012142376,0.008324431,0.036998402,0.015079063,0.12549397,-0.084076196,-0.0765401,0.027324935,-0.04282734,0.03679323,-0.038642406,0.09709273,0.06025385,0.011720835,0.020913724,0.13020523,0.005040563,0.036978617,-0.10304659,-0.05944315,-0.026632505,0.11842775,0.0065712747,0.012361529,0.06198229,-0.0516833,0.006434612,-0.0025749747,-0.0041754856,0.10913964,-0.01643658,-0.03615974,-0.07887235,0.04610239,-0.034521006,0.044959728,-0.063725874,0.0066709365,0.04268107,-0.026078442,-0.02381047,0.018186908,0.10985467,0.0124259675,-0.023906088,-0.051453594,0.0024211747,-2.0458252e-35,0.02396996,-0.013907319,0.078834,-0.18349618,-0.033027794,0.10596509,0.032741755,-0.11998464,-0.0077690096,-0.020975608,0.06226829,0.006801091,-0.028840838,-0.08854182,-0.0031442787,0.01349619,-0.05503089,0.02147289,-0.022911472,0.015387629,0.0002802818,0.10909912,-0.009934941,0.05265535,0.039378244,-0.036612973,-0.032034043,0.096785784,0.025997516,-0.06596727,0.036196325,-0.04672774,-0.07586636,0.012692314,0.021844177,-0.04535078,-0.039520044,0.035218887,0.029131465,0.057998717,0.01632705,0.038878303,-0.07417973,0.022135701,0.027766699,0.0048664683,-0.063588366,-0.078693554,0.056514755,-0.11244625,0.013327738,-0.02834013,-0.063326485,-0.022137355,0.028928434,0.0769917,-0.0140878055,0.08054858,0.014061054,-0.044744216,-0.03172948,-0.0383869,0.06938936,-0.014597049,0.022444643,0.043511104,0.002168591,-0.06527249,-0.04086298,-0.006389156,0.050040226,0.100487225,-0.036652885,0.04012758,-0.03601372,-0.107142426,-0.031003796,0.0137081975,-0.04224065,-0.011140886,0.025600428,-0.0064409263,-0.059259545,-0.027248934,-0.003502651,0.015192776,0.015596601,0.054033946,0.033265393,-0.017043523,-0.011598813,0.011129275,-0.116721466,0.0027771667,-0.055868052,-3.0645783e-08,0.052843302,-0.026829315,-0.038219094,-0.06322183,-0.0492108,0.020922463,0.041595098,-0.06941897,0.04674307,0.06862135,0.051245835,0.08825316,0.04724553,-0.02224008,0.069028735,-0.049911495,-0.024629215,-0.0011702486,0.0033548078,-0.016267054,0.041047435,0.028160116,-0.044829324,0.09272826,0.060545627,-0.027111998,-0.0042392416,-0.03514116,0.041314837,-0.047689438,0.029917851,-0.052916877,0.08128703,0.023695327,0.004912026,-0.0032168147,0.039165482,-0.0064308364,-0.06914352,0.09886029,0.031165635,-0.12186308,-0.08256543,0.04677673,0.002567783,-0.02698799,0.04895608,-0.0212464,0.011142282,0.06276353,0.020980002,0.014499723,0.008027505,-0.09139009,-0.07092266,0.049307384,-0.036779176,-0.0486748,-0.007365493,-0.06406632,0.14540698,0.06358633,0.12128013,-0.011959939 +1.6.2.2,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.6.2.4,"A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases (e.g. EC 1.14.14.1, unspecific monooxygenase) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. It also reduces cytochrome b5 and cytochrome c. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.",384,1.0,-0.11867693,0.035412215,-0.07968562,0.023891063,0.06644654,0.046660207,-0.010988485,0.084157325,-0.023752177,-0.07011065,-0.013786616,0.0059158774,-0.092380986,0.0069320234,-0.10767135,0.045522053,-0.072947174,-0.019074304,-0.02445925,-0.017509837,-0.013124122,0.0017347508,0.08211511,-0.021150654,-0.0033732168,-0.021985533,0.02366324,-0.019839229,0.0047150184,-0.012001983,0.09006245,0.088833526,0.037538815,0.0076403306,-0.049137145,0.06414762,0.025761196,-0.02456235,-0.01552518,0.023209564,0.04255556,-0.020340323,-0.024395036,-0.017222643,0.031820018,-0.029386414,-0.0030160516,0.08057621,-0.012652193,0.042302374,-0.03604812,-0.0070341867,-0.12168141,0.076784395,0.0672631,0.0008162535,-0.044827033,-0.07977555,-0.06983499,0.041294694,-0.00087788084,0.022594722,-0.021565257,0.0209045,0.11690966,-0.05404795,-0.0076857004,-0.13059084,0.008011727,-0.012197358,-0.016267113,-0.04501442,-0.067428015,-0.050452914,-0.03563528,0.06376711,-0.07309139,0.0016548168,0.048887547,0.001689354,0.039410144,-0.015640145,0.018721346,0.08892291,0.05344271,-0.037975203,-0.054215245,0.020808255,-0.039443515,0.042016756,-0.02137578,0.013691239,0.05806839,0.040569954,-0.12056129,0.086691715,0.04892983,0.028273996,-0.045669977,0.022617273,-0.0053370586,0.037415314,0.043067265,-0.020840855,-0.14009498,-0.057098184,0.024068493,0.059648927,0.038904388,-0.076549046,-0.006445045,-0.026865378,0.019122964,-0.045633223,-0.0010650151,0.08400429,-0.0073094335,-0.027530892,0.002482114,0.017068284,-0.030797385,0.043167267,0.03792877,0.057376202,0.024978202,0.046585936,-0.14012368,3.8774375e-33,0.08854582,0.015549083,0.007518841,-0.011501824,0.002416813,0.007931248,-0.021896213,-0.014600815,0.0076852543,-0.0048303544,-0.050675157,0.002917659,0.09034632,-0.03653696,-0.011948724,-0.07214203,-0.04746755,-0.007326831,0.0833499,-0.047907762,0.052278172,0.009014439,-0.042146143,0.04697086,0.05197903,0.026439285,-0.062769234,0.036139548,0.003994731,0.04480599,-0.020351266,-0.037317015,-0.07344016,-0.017978024,-6.990106e-06,-0.012287063,-0.08972965,-0.05443572,-0.085426316,0.066576175,-0.08619897,-0.0071260175,-0.044965077,-0.043463275,0.09983195,-0.100735776,-0.09344503,0.08064299,-0.004784825,0.10962165,0.041102666,-0.046370305,0.10095949,0.028827671,-0.038542517,0.05351092,0.006085376,0.021202462,-0.0067685433,0.023659067,0.076659024,0.031750172,-0.016095994,0.041970894,-0.00028151346,0.010719043,-0.004782628,-0.08182199,-0.015705217,0.115305856,-0.009411568,0.03134321,0.08589465,0.0028226743,0.05231806,-0.026097832,0.012470029,0.0074740904,-0.008773982,0.030417318,0.001865802,0.005616974,0.005428362,-0.07717626,-0.008417901,0.020775877,0.0018338378,-0.07984572,-0.009163922,-0.028887566,0.07128294,-0.113633625,0.0011861972,-0.056372724,0.02432578,-2.9263036e-33,-0.0025185521,-0.07899686,-0.05283374,-0.03396707,-0.035611574,0.046538137,0.06212126,-0.046556517,-0.01332435,-0.008347283,0.07046095,-0.033038512,0.035204574,-0.022214765,0.03340941,-0.0059349923,-0.01910945,0.0371387,0.0565599,0.054812435,0.0240441,0.048416536,0.023761377,0.061327215,-0.009823736,-0.0064839637,-0.0311515,-0.02637811,0.09614136,0.027391637,-0.11075925,0.022037134,-0.07851196,-0.022082038,0.02595629,0.025995065,0.012240035,0.05348797,0.00066167995,0.043612044,-0.00066074124,0.002777901,0.06531542,0.078203425,0.055714436,0.0697096,-0.11431002,0.00048153073,0.05146832,-0.029752614,-0.017611543,0.06992691,-0.043661144,0.06684653,0.026723126,0.021005098,0.072946094,0.04297865,0.038105562,-0.02185602,-0.030037433,-0.10638484,0.003034605,0.060607247,0.059674036,0.056148622,0.0024195644,0.09836923,-0.022344965,-0.017346902,0.05800453,-0.010814503,0.09041361,0.036631215,-0.034157157,-0.016992765,0.012974523,0.03876995,0.0034563064,0.01365276,0.053970296,0.007504362,-0.020598648,-0.07166099,-0.054851618,-0.13233607,0.028231617,0.04646363,0.008341862,-0.010655141,-0.008291622,0.049364854,-0.008682436,-0.08956456,0.036016915,-3.90181e-08,0.014329223,-0.07138553,-0.0019713715,-0.006467139,0.1276705,0.025971236,-0.054230016,-0.013609912,0.018517066,-0.033580523,-0.0010058957,0.12459448,0.014720366,0.033707667,0.060694695,-0.03970781,0.011577913,0.0032155826,-0.025402041,-0.06509117,-0.079792194,0.04878944,-0.022133393,0.01633104,-0.021020543,-0.04731783,0.014658425,-0.016639564,0.07518991,-0.052059002,-0.023293654,0.056360733,0.033542715,-0.026375644,-0.13163692,-0.003990791,0.014857572,-0.0047046123,-0.07991577,0.050334353,-0.060478877,-0.06955133,-0.024734518,-0.023085615,0.063999996,-0.0030662394,0.05697281,-0.042969238,-0.060043182,0.019942079,0.006801443,-0.012901324,0.003891775,-0.05323753,-0.08792827,-0.0026015982,0.011411453,-0.04645168,-0.0016352372,-0.089246586,-0.0067077545,0.06946064,0.12654278,0.02906637 +1.6.2.5,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.6.3.1,"Requires FAD, heme and calcium. When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen. The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups. This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalysed biosynthesis of thyroid hormones.",384,1.0,-0.06786265,-0.0026824027,-0.07613526,-0.006489448,0.09259886,0.012874619,-0.02264467,0.05639868,0.022332681,0.03350646,0.0020040723,-0.03941356,-0.08369556,-0.035724983,-0.041853443,0.007678138,-0.10794058,0.008651505,-0.02815486,-0.06761855,0.035988823,-0.020537125,0.0077485037,-0.082400694,0.010191873,-0.034048785,0.040526018,0.0045322785,0.03348637,0.0024514976,-0.006837096,0.0049594603,-0.012624322,-0.07574703,-0.038059007,0.10627781,0.023567034,-0.0632157,-0.06037127,-0.06289977,0.089988746,-0.061064456,-0.029675538,0.023705723,0.042970847,0.005038806,0.0766614,0.025638247,-0.022172665,0.0252507,-0.016136598,-0.021458082,-0.061391756,0.040588275,-0.053131286,0.10485202,-0.0014094032,0.058495495,0.031569533,-0.038120214,-0.046840623,-0.068709396,0.049641743,0.016690286,0.09908003,-0.08014054,-0.020907091,-0.05774344,-0.054014765,-0.039350245,0.009014596,-0.041177,-0.024110578,-0.06095569,0.014677253,0.04952992,-0.08713792,-0.030383375,0.09403195,0.033653833,0.07372695,-0.006407752,0.09152151,0.12076626,0.061293524,0.06969719,0.0040795146,-0.0151375495,-0.1285635,0.03355267,-0.018532518,0.02729021,0.00056877104,-0.01983418,-0.039851867,0.106302574,0.09902434,0.008264437,-0.0076942206,-0.0398024,-0.018689651,0.061659567,-0.002292609,-0.017130489,-0.04305317,-0.0101749515,-0.057146378,0.039828975,-0.03538983,0.0293266,-0.0072753825,0.026922734,0.026211623,-0.038780008,0.007946986,0.068003304,-0.023268897,-0.014929463,-0.009829751,0.010871969,-0.033370577,0.032102123,-0.004156565,0.055389773,0.029944364,-0.06694345,-0.114370756,6.307855e-33,0.07933675,0.044944894,-0.018845007,-0.009882782,-0.014412378,-0.010964345,-0.07264105,-0.04106705,0.008511189,-0.001049834,-0.066966474,-0.07461866,0.030696865,0.0073228055,-0.005676719,-0.03631238,-0.045331553,-0.04538429,0.06309532,-0.048248425,0.06857958,0.05335161,0.010479985,0.050268337,0.079850435,0.05257471,-0.0335452,0.01557644,0.009398171,0.002621295,0.0142531395,-0.104030825,-0.0016119137,-0.0075059677,0.0017860455,-0.004006489,-0.06372464,-0.039845552,-0.049143575,0.10828789,0.046486143,-0.0035055836,-0.0014303328,0.007737321,0.05622668,-0.09471597,-0.047270685,0.010262097,0.059465785,0.11948412,0.003412674,-0.041182414,0.043964718,0.019567452,-0.0441551,-0.039509483,-0.07046016,-0.039295208,0.027708411,0.05162969,0.011814723,0.03329035,0.0064717545,0.09396495,-0.0030331267,0.0024481737,-0.05559285,-0.046925284,-0.000716857,0.08433508,0.012964448,-0.016013574,0.07372795,-0.016408395,0.04115075,-0.009802531,-0.005099626,-0.0032886057,0.051985994,-0.052600168,0.056400772,-0.0005835993,0.0057462924,0.0320779,0.017596252,-0.04064605,-0.04901115,-0.08157351,-0.0046476447,0.04422295,0.05930238,-0.08483908,-0.014057837,-0.073066406,-0.0067826095,-6.0928106e-33,0.05770289,0.014714199,0.03689,-0.08827719,0.018172517,0.07394723,-0.0061010746,-0.10875501,0.10341178,0.00422062,0.03070976,0.016363349,-0.011012648,-0.033043694,-0.040401816,-0.0005022798,-0.02918378,0.0069323997,0.025353763,-0.0011169929,-0.020781666,0.049231388,0.07410374,0.06793356,0.0844557,-0.034520138,-0.0166064,-0.025180949,0.04981298,0.08757111,-0.07914595,0.022460805,-0.07716042,0.024591194,-0.0080957515,-0.02029949,-0.041557666,0.082210235,-0.0004425408,0.052686814,0.021977957,-0.061751902,0.0426527,0.026608782,0.011775003,0.020383475,-0.10878976,0.025167977,-0.00940508,-0.028126976,0.01945415,0.022162436,-0.07786853,0.017628357,0.04299612,0.04835672,0.03343967,0.076552935,-0.016685914,-0.0022758555,0.016642947,-0.086763166,0.020103594,0.006373916,0.06054297,0.056990396,-0.034818318,0.0724776,-0.057092678,0.089577585,0.055500284,0.023808122,0.03845765,0.036864918,-0.0052002654,-0.015910892,-0.03738035,0.039450027,0.095180176,0.015673364,-0.0246101,0.06668276,-0.016218219,-0.026665619,-0.0024754107,-0.10569327,-0.005759529,0.06897245,0.025187409,-0.020880118,-0.033766508,0.031120894,-0.040629797,0.002249159,0.048419815,-4.1682004e-08,-0.0011619631,-0.07910353,0.039552305,-0.020900121,0.042212896,0.029600928,0.007092358,-0.03759955,0.038375597,-0.020832669,-0.05476885,0.105038986,0.027132168,-0.07957677,0.044653405,0.025832528,-0.011226325,0.08883511,-0.053958494,-0.1233235,-0.117124215,0.026306814,-0.11264259,0.047250748,0.016798439,-0.050270487,0.012024634,-0.005893141,0.0022735999,0.025676817,0.02409765,-0.03513711,0.011710501,-0.090416186,-0.08523401,-0.0046007913,-0.0056257537,-0.025171164,-0.051930867,-0.033149276,-0.046294637,0.006286608,0.03906145,-0.019130297,0.0051794066,0.055885017,0.030159509,0.0073772953,-0.019887784,-0.0032786308,0.029369269,-0.054948077,0.003627883,-0.12968566,-0.11992238,0.05526526,0.014591533,-0.05540173,-0.013780588,-0.093852095,-0.045248136,0.10707849,0.19403479,-0.027335556 +1.6.5.2,"A flavoprotein. The enzyme catalyses a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone [6]. The animal, but not the plant, form of the enzyme is inhibited by dicoumarol.",384,0.99999994,-0.09094188,0.030082885,-0.03484358,0.012162455,0.052629776,0.031073838,-0.03789332,0.051434256,0.057254225,-0.014169183,0.040152594,0.019792203,-0.062055726,-0.0075690746,-0.077569425,0.09845546,-0.050739054,0.020146549,-0.0298278,-0.0007673096,-0.03151596,-0.05544623,-0.018598028,0.02035143,0.0487337,-0.005785311,0.015871143,0.040765613,-0.042078618,-0.039907016,0.038748454,0.026603814,0.024290781,-0.020507997,-0.106773645,0.03276065,-0.03363707,-0.041281644,0.04123785,0.021395184,0.015961956,0.02197998,-0.005760239,-0.008496389,0.038014494,-0.016536003,-0.033377666,0.07965591,0.04173777,0.042949565,-0.042409077,0.018388603,-0.082348764,0.10220194,0.026409844,0.014745354,-0.05290967,0.034678083,-0.046155587,0.06737758,0.0114313,0.0068003824,-0.030654604,0.00879432,-0.013292522,-0.055541586,-0.06718532,0.020928629,0.043944646,-0.027373815,0.018569995,-0.0692488,-0.029789643,-0.023662122,0.010287593,0.06368548,-0.06475868,0.03923298,0.07008798,-0.017045787,0.053265482,-0.05143491,0.018046321,0.09878736,0.07394249,0.029595945,-0.026658177,-0.023237944,0.04391787,0.017939858,0.04587555,-0.0014351031,0.012683469,-0.04926143,-0.037756838,0.09313293,0.037208483,-0.003728566,-0.081703745,0.027542342,0.035607856,-0.027699308,-0.025365612,-0.10763664,-0.1103421,0.032579362,0.027931236,0.024167426,-0.012331152,-0.06663351,-0.012733439,-0.01901164,-0.0023610909,-0.009938576,-0.028166724,0.096085526,0.06886624,-0.09185707,-0.051097285,-0.017084025,-0.032593906,0.03538026,0.087114856,0.026007652,0.02009782,0.044639353,-0.08116324,1.4681843e-33,0.043629523,0.015598814,-0.04008288,-0.03753657,0.03263331,0.017594695,-0.076379344,0.036245685,-0.07914897,-0.09215,-0.046987746,-0.026551194,0.013517192,-0.0012926024,0.029810335,-0.039504383,0.04663124,0.0056510284,0.0835485,-0.0696699,0.050948758,0.013676952,-0.0662672,0.030669857,0.021382323,0.031638164,-0.061470382,0.012267821,0.012591547,0.030503444,-0.027525093,-0.064963974,-0.052191377,0.04145793,-0.029287156,0.01717721,-0.13957906,-0.063047625,-0.07569441,0.048954975,-0.015384987,0.00021030055,-0.04648013,-0.01911136,0.0361941,-0.056899786,-0.04168552,0.06350243,-0.024991453,0.042696793,0.044069543,0.0038490745,0.105357975,0.033596616,-0.07839897,0.06571615,0.053249832,0.013842561,0.023854153,0.020995697,-0.03790592,0.0876771,-0.06548667,0.03828458,-0.0194664,-0.019223778,-0.059227247,-0.059642944,-0.022860141,0.10208323,0.008892748,-0.021563893,0.057521023,-0.003352572,0.07433275,-0.03637903,-0.057580132,0.0015264653,0.021328922,-0.026953511,-0.03812041,-0.07254782,0.012264211,0.03004273,-0.04763433,-0.0024123366,-0.009774885,-0.058383428,0.008670268,-0.04960257,0.06759624,-0.036390178,-0.052678924,-0.019390903,0.09253081,-9.1141945e-34,0.04922486,-0.08142314,0.03006015,0.01812932,0.0060506477,0.07417104,0.032575212,-0.12199189,0.046731964,-0.041792832,0.05155183,-0.081045315,-0.022242358,-0.021903554,0.041671764,-0.022580968,0.0038416027,0.031651236,0.036992073,-0.04481712,-0.0319557,0.025648015,0.069156334,0.041668046,0.0014501088,-0.013724497,0.010405943,-0.030895907,0.07361242,0.04284543,-0.085289225,0.021776678,0.0037559723,-0.03232963,0.00096915604,0.05747641,-0.06917686,0.03419504,-0.0023963281,0.06473309,-0.0028170506,-0.024391051,0.007982579,0.07839366,0.03921386,0.07219513,-0.08258687,0.09467173,0.017906943,-0.026089376,0.051107712,0.084919095,-0.009120198,0.10099,0.09336966,0.038756784,0.073131934,-0.052696697,0.027318457,0.0043814923,-0.05591088,-0.091552824,0.0023151597,0.012888432,0.049409397,0.0791498,-0.008568423,0.14906855,0.0073937443,-0.056060854,0.1223431,-0.019213319,0.042688858,0.07685449,-0.041544277,0.025598835,0.014834955,-0.02162543,0.0033563694,-0.0076293503,-0.013284911,-0.047131278,-0.019737141,-0.036112458,-0.08918212,-0.119255856,-0.07017567,0.0834873,0.0050806394,0.07131449,0.016252212,0.041926406,-0.021018954,0.016334401,0.07881251,-3.7545426e-08,0.010118064,-0.08308595,0.02951465,-0.011197685,0.0329057,-0.018143877,-0.014849749,0.058173604,0.020862954,0.018385626,0.0033234628,0.0817095,-0.040696066,0.02807153,0.06050837,-0.006940957,0.08910305,-0.000511265,-0.050651662,0.013481119,-0.06275614,0.023292921,-0.12810123,-0.050928943,-0.05378089,-0.10204975,-0.0094926655,-0.007307695,0.0029308698,-0.0002486577,-0.00389543,0.06195888,0.018347677,-0.047540467,-0.11354778,0.029954558,0.013145341,-0.039859515,-0.017000504,0.0025903033,-0.030487955,0.010127684,-0.058303103,-0.026103245,0.015592015,-0.019792693,0.08611933,-0.020800484,0.017897602,0.02477478,0.0001600786,0.014647522,0.062420715,-0.081832826,-0.08876245,0.022599244,-0.005448606,-0.049981635,-0.017457671,-0.1438927,0.0003859515,0.012435329,0.19675961,0.052478813 +1.6.5.3,"A flavoprotein (FMN) containing iron-sulfur clusters. The complex is present in mitochondria and aerobic bacteria. Breakdown of the complex can release EC 1.6.99.3, NADH dehydrogenase. In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD+ to NADH.",384,1.0,-0.0871284,0.01080724,-0.12759191,0.09308896,0.105804786,0.03144276,-0.034491904,0.04857054,0.037041392,-0.0656919,0.037998185,0.019145897,-0.06353123,0.013489704,-0.07497335,0.0058858683,-0.059267018,-0.005398833,-0.048782904,0.022292826,-0.017627697,0.04020264,0.016678682,-0.05998172,-0.05286184,0.0300115,-0.001969931,-0.003643649,-0.047696747,-0.05182747,0.07262745,0.03799624,0.038820185,0.00019668075,-0.020235533,0.11012364,0.035313796,-0.06972736,0.020467887,-0.00470054,0.022446176,0.00024212613,0.006964749,-0.0614219,0.03128605,-0.008973201,0.0006642168,0.062739626,0.029241888,0.010723104,-0.06251221,-0.0064622574,-0.05358196,0.13174243,0.07587211,-0.0058554425,-0.0033456727,-0.0652047,-0.08293783,0.020494437,0.032198273,-0.015595454,-0.01921553,-0.027180608,0.08027133,-0.057930183,0.02642664,-0.04393241,0.042819746,-0.048056062,-0.03080903,0.0014706339,-0.080029525,0.016673187,-0.03768833,0.102873564,-0.031638023,-0.03789125,0.07691824,0.0018713278,0.04151287,-0.013181152,0.024110567,0.08999773,0.03184206,-0.055030305,-0.008903849,0.0034998702,-0.037482817,0.08407899,-0.0688378,-0.00052007043,0.005384994,-0.011327794,-0.11274141,0.057136975,0.050336402,0.039532192,-0.018403022,0.019746227,0.0026431116,0.0513888,0.012383267,-0.0678012,-0.08421259,-0.023869002,0.039017823,0.1124023,0.0030194968,-0.0182479,0.017356435,0.012919151,-0.00992837,-0.1014153,-0.019784953,0.073778965,0.0471909,-0.03297834,-0.085573584,0.036623664,-0.027033385,0.060684316,0.026549174,0.07353265,0.05434016,-0.0050009815,-0.20122342,2.2739547e-33,0.055335592,0.008270154,0.061490927,-0.025678826,0.00536733,-0.05237093,-0.06951508,-0.017888246,0.042193707,-0.025931654,-0.113244876,0.007168432,0.049820106,-0.075431615,0.012713625,-0.056523945,-0.05818825,-0.03396447,0.044532552,-0.0012004585,0.078925304,0.0055840123,0.016881697,-0.0216901,0.038128793,0.04835617,-0.033707347,-0.001306053,-0.004979386,0.011406921,0.05569853,-0.094755575,-0.09676626,0.0019377337,0.09754835,0.015094828,-0.0723798,-0.060475096,-0.06405022,0.044745,-0.06981911,0.0038647207,-0.034942217,0.005902715,0.043888543,-0.019429835,-0.03513265,0.045129057,0.012272837,0.05329558,0.0357857,-0.06204301,0.10339482,0.0027851395,-0.053900417,0.026693065,0.024310289,0.008658685,-0.001474608,0.082921,0.023924904,0.032979235,-0.045618314,0.08112187,-0.0037228486,0.011562338,-0.04941162,-0.015951894,0.059698354,0.060815185,-0.0059823496,0.008529243,0.119646974,-0.016290866,0.025305541,0.038498074,-0.05911653,-0.030066002,-0.03460139,0.021378048,0.006671365,-0.07986375,-0.040995646,-0.039604135,-0.079678975,0.050738655,-0.00037437916,-0.0140563045,-0.020240748,-0.04364034,0.06524386,-0.02093776,0.003736368,-0.09899149,-0.00212566,-2.5512467e-33,0.032913662,-0.04436976,-0.04405877,-0.07922402,-0.021688627,0.09700771,-0.005032478,-0.024930764,-0.052053157,0.020756397,0.03526219,-0.034205057,0.0004923278,-0.05691604,0.027664246,0.017544018,-0.00917529,0.03985971,0.04746032,0.01039808,-0.04702338,0.068103984,0.057700127,0.04305815,0.028560601,0.01234714,0.009947417,0.014631316,0.073929965,0.051988997,-0.044912875,-0.0024963059,-0.039973643,-0.051505152,0.052808084,0.017934458,-0.03779225,-0.026819164,0.047450583,0.005484317,0.03368064,-0.044381276,-0.0030646871,0.094042346,0.041874565,0.050067246,-0.12781817,0.02060979,0.05545551,0.015618563,0.031568456,0.0040589673,-0.06693659,0.050042912,0.050734792,0.03428579,0.028191308,0.06999042,0.02418136,0.023011902,-0.0345938,-0.12541573,0.027039142,-0.021092003,0.017334534,0.043527268,0.025157925,0.06361372,0.0097266305,-0.00219439,0.07947109,0.022417562,0.070740476,0.023603266,0.007723438,-0.014331223,-0.017663697,0.10012892,-0.044089165,0.03433623,0.024778472,-0.019563057,-0.030364344,-0.09709457,0.06569523,-0.09826052,-0.008988061,0.033177417,-0.018547574,-0.015262656,0.0023236542,0.03706524,-0.0371181,-0.050756343,-0.059879515,-3.368839e-08,-0.0005226267,-0.097545594,0.030858949,0.0038886091,0.08092936,0.017538743,0.028498108,0.019052487,-0.020899963,0.062172595,0.04136065,0.13534419,0.016723923,-0.043740552,0.053114623,-0.030170023,-0.00028255457,0.0066186558,-0.02550879,-0.03191634,-0.057313304,-0.013782893,-0.10781388,0.051932022,-0.0004840662,-0.059166748,0.007317737,-0.057585068,0.06089584,-0.09128122,0.04745767,0.05237555,0.04210486,-0.025047263,-0.1690071,-0.01931032,-0.030586103,-0.011088894,-0.072122514,0.06291113,-0.07100415,-0.0034422835,-0.06620094,0.019838046,0.008096628,0.030950036,0.05662447,0.060966026,-0.05978688,-0.007901851,-0.0045691854,0.0054757227,-0.012200552,-0.011982815,-0.11287933,0.034856103,0.009439369,-0.06746657,0.021133594,-0.005958791,0.019078353,0.0013661337,0.10131781,0.012218419 +1.6.5.5,"A zinc enzyme, specific for NADPH. Catalyses the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates [1]. Dicoumarol [cf. EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)] and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2 [1]. In some mammals, the enzyme is abundant in the lens of the eye, where it is identified with the protein zeta-crystallin.",384,1.0,-0.06251785,0.036013987,0.020899843,-0.023029873,0.0938795,0.003172929,-0.006308021,0.08663197,0.025355272,0.050517976,-0.020017691,0.022906326,-0.0074153147,0.0220744,-0.059443604,0.082369015,-0.05406395,-0.016938077,0.0045830896,0.022355502,-0.009423668,-0.03910483,0.015006718,0.0075590503,0.08232817,0.017825386,0.02083115,0.066762574,-0.05212733,-0.004372884,-0.04643476,-0.008071723,-0.048903078,-0.0035255093,-0.08839902,0.02928573,-0.025867976,0.021039888,-0.020473035,0.024029303,-0.00036910523,0.04023439,-0.1334478,-0.012252615,0.0680429,-0.038883906,0.04805821,0.06143198,0.033446863,0.06478035,-0.13292971,0.0012212937,-0.012863134,0.10230974,0.05851278,0.045899972,-0.10216588,0.025035674,-0.015605282,0.04718319,0.008557909,-0.06037828,-0.059352595,-0.0054546823,-0.015084653,0.029006986,0.011270965,-0.0429455,-0.0012655089,-0.06484056,-0.0521929,-0.026322423,0.017783478,-0.059862953,-0.059903752,0.08188257,-0.019595359,-0.044325404,0.04271871,-0.010670288,0.064436086,0.02014041,0.012260319,0.09698558,0.09126529,0.050952453,-0.012385148,-0.0017109609,0.046725918,-0.00945584,0.008077323,0.002199261,-0.03189881,-0.05953736,-0.08716571,0.04599718,0.010717481,0.008393339,-0.0021940751,0.049985483,0.046526946,0.036780655,0.011955336,-0.14711766,-0.11454234,0.0678774,0.049607664,0.068993025,-0.053203486,0.0017842073,-0.011692796,-6.6710876e-05,-0.021551628,0.023903001,-0.03797295,0.093787484,0.04759534,-0.052412633,-0.0621428,-0.011339674,0.004406499,0.01882272,0.09038157,0.004765929,0.02068912,0.07376798,-0.053326074,1.9864021e-33,0.076777644,0.081396334,-0.00945927,-0.023167448,0.017149378,0.036770497,-0.08507683,0.11075541,-0.08628407,-0.053679552,-0.038415235,-0.048149068,0.0118334545,-0.02209195,-0.005083954,-0.03437911,0.04133726,-0.02177252,0.00024084424,-0.024288919,-0.007417816,0.02731468,-0.10198684,0.008742728,0.015806906,0.027658679,-0.07031404,0.014283705,-0.03768272,-0.002874788,0.048051603,-0.06539788,-0.025018323,-0.03810017,0.05398498,-0.02370966,-0.09588852,-0.022259587,-0.028723322,0.01182138,-0.07690588,0.053916913,-0.015209469,-0.025611676,0.03051142,-0.08864197,-0.012384008,0.09881867,-0.010377804,-0.01875768,0.045267876,0.011052061,0.052135006,-0.059985645,-0.07391567,0.031741545,0.012881792,-0.0052859113,0.057684142,0.05504773,-0.00047741205,-0.015942505,-0.04860673,0.07261037,-0.0042542815,-0.057905734,-0.10699126,-0.04456062,-0.0707864,0.061721355,-0.0018928023,-0.007961189,0.036185924,-0.015960213,0.039729584,-0.05105468,-0.02027002,-0.011340827,0.047709253,-0.012344688,-0.0060494407,-0.05896713,0.012570379,0.00077690074,-0.035967488,-0.016342763,0.040797655,-0.053272508,-0.049627416,-0.059917703,0.09278761,-0.017637935,-0.052813906,-0.12388207,0.046371292,-2.1743055e-33,0.041694075,-0.041482393,0.021080181,-0.050493576,-0.0053606224,0.14876698,0.050141364,-0.06830178,0.044494458,-0.07860452,0.08010251,-0.019725379,0.03750797,-0.020632152,0.014688132,-0.0480246,-0.026563976,0.04986987,0.037655067,-0.03073441,-0.006900392,0.10200773,0.067783095,-0.018929688,0.0247186,0.015442852,-0.013811175,0.021488661,0.043163214,0.12748535,-0.0511259,0.015228081,-0.039012324,-0.051460553,0.037875257,0.07784533,-0.054676227,-0.0118043125,-0.03401651,0.052562613,0.022411004,-0.087021194,-0.010781784,0.031741157,-0.0057404586,0.047227215,-0.119097136,0.056463864,-0.021355508,-7.0167625e-05,0.04960199,0.07999759,-0.03545681,0.011108882,0.0646611,0.037633408,0.025643893,-0.057710927,0.069410235,-0.0035498973,-0.040217098,-0.06562642,-0.028664982,0.04762166,0.015686126,0.04147131,0.00083493476,0.09266883,0.06344605,-0.0667552,0.05159784,0.028516805,0.008773013,0.0467548,-0.0617405,0.031181505,0.008292442,-0.013806946,-0.047793094,0.033093475,0.040357105,-0.016192237,-0.03743871,0.005565527,-0.09707865,-0.01926297,-0.010736855,0.07833873,-0.07567942,0.0037761177,-0.014335065,-0.005174671,-0.069597304,0.072001725,0.021555822,-4.1703327e-08,0.057870682,-0.079459414,0.068189785,-0.0367383,-0.02240982,-0.009302349,0.028798483,0.05774463,-0.023600465,0.031568255,0.075795315,0.1062018,0.009830994,0.04009349,0.066218056,0.022164239,0.07334621,0.010171091,-0.07476331,0.0074359914,-0.018052146,0.029760972,-0.11111095,-0.02636507,-0.006946176,-0.087613024,-0.0020211868,0.035644684,-0.048558977,-0.024072163,0.027653212,0.0002847806,0.0599362,-0.03651864,-0.101789266,0.010148952,-0.047700737,0.031260423,-0.045562766,-0.025553653,-0.061854403,-0.016567493,-0.043053243,0.03329476,0.012937296,-0.043493304,0.107557796,-0.0325549,0.040203735,0.02406128,-0.009416637,0.0031908336,0.06610428,-0.10399261,-0.11373619,0.04475585,0.030051062,-0.05230817,-0.04369996,-0.1083376,-0.0010746458,0.002422334,0.111433595,0.004053535 +1.6.5.6,Involved in the 4-nitrophenol degradation pathway in bacteria.,384,1.0,0.003249642,-0.0198383,-0.009051085,-0.03553252,0.06016543,0.03898463,-0.01803278,0.02050283,0.07913231,-0.0484874,-0.038835842,0.0006926525,-0.034521863,0.05876772,-0.06892414,0.052543037,-0.08342421,0.06690482,-0.025133887,-0.018868677,0.015134647,0.0005687873,-0.049039066,-0.06826583,-0.05658654,0.047243327,0.02222543,-0.07162818,-0.022058917,-0.027088864,0.05054989,0.024450902,0.02836841,-0.050418235,0.09957113,0.047868717,0.06206901,-0.059822403,0.08420317,-0.008018885,0.01803745,-0.0052781543,-0.03546097,0.041357722,0.026721455,0.045230947,-0.012831861,0.020126255,0.08867556,-0.12295296,-0.08858489,0.0018772557,0.03788532,0.040163744,0.037348468,0.04206071,-0.0069558085,-0.09343505,-0.01833269,0.059554532,0.09157373,-0.04631363,0.049589425,-0.03960276,-0.04432549,0.05387285,0.05407703,-0.013888255,-0.0014608247,0.028250312,-0.09672941,-0.03474539,0.019818915,-0.007190276,-0.009855038,0.02465934,0.06965743,-0.04189845,-0.00010211378,-0.08368955,0.039443754,0.050113883,0.04277569,0.034737732,0.008452613,-0.0787621,-0.0037451393,-0.018460667,0.0077677704,0.119814225,-0.048066854,-0.004942584,0.09843477,-0.038260486,-0.06637231,0.045100477,-0.044668786,-0.023042645,0.047293663,-0.005203713,-0.0455909,0.01955759,-0.04008626,-0.043518625,-0.07441377,0.03422157,0.018295491,0.12734418,0.028967632,0.075380586,0.03827803,0.015143084,-0.0195003,0.023814445,-0.014449902,0.01461099,0.043383922,-0.0006121433,-0.113674566,0.0316799,-0.062269587,-0.06249898,0.030513342,-0.008785482,-0.10138182,0.05602611,0.07925461,-1.1184324e-33,0.08205674,-0.018956188,0.01572306,-0.018219026,0.0577331,-0.030416045,-0.10217371,-0.034024253,0.03706425,-0.07380272,0.009170078,-0.09079249,-0.075425334,-0.06899245,0.004489367,0.07912825,-0.08186341,0.07155748,0.018818619,0.033620976,-0.015311686,-0.0019864626,-0.06395804,-0.023005772,0.034399424,0.052007023,-0.016482666,-0.019298756,0.015035545,-0.035146534,0.00020625726,-0.07149807,-0.052586317,-0.0019135767,0.09766033,-0.024590064,0.0021714822,0.030574488,-0.0051597133,0.048911426,-0.05669741,0.060009245,0.031865273,-0.025810229,0.03542878,0.011589339,-0.033790376,0.072894625,0.018205013,0.035189703,-0.036975347,-0.040070195,0.04277527,-0.012780758,-0.020784989,-0.02772385,0.022780232,0.007295797,0.02312667,-0.13662809,-0.001150847,0.046633575,-0.031845078,-0.023167906,0.10672519,0.031183796,-0.03323269,-0.025916934,0.035506688,0.040547535,-0.08037393,0.019854227,0.0023717459,0.023104439,0.014289434,-0.063931815,-0.094219,0.0119079705,0.051889133,0.045421716,-0.03011532,0.026003487,0.002132044,-0.047526915,-0.0046067475,0.067422695,0.015550893,-0.004674306,0.041470904,-0.07163209,0.084088005,-0.07839599,-0.051970057,0.0008603482,-0.047639254,2.3915191e-34,0.06618226,-0.051550765,0.0068492056,0.03544007,-0.053248927,-0.0045886743,-0.10342847,0.04777776,-0.014863332,0.030015526,0.06487137,0.020492578,0.0150913745,0.04710179,0.026667465,-0.04623945,0.052559767,0.026416097,-0.0912397,-0.050716843,0.027645081,0.0034116162,-0.008001317,0.025936153,0.0012090865,0.047035716,0.010423805,0.017610079,0.06081982,0.01692214,0.068079464,0.08118648,-0.06015793,-0.046364937,0.08055009,-0.03655525,-0.06444037,-0.008084508,-0.014765486,-0.036889184,0.061199863,0.024602428,-0.00048016798,0.00496645,-0.032104854,0.05703014,-0.09065516,0.02336174,0.043236025,-0.020778416,0.021171674,0.018386515,-0.11286383,0.02735847,-0.02610269,0.0051444233,0.063785136,0.0095844185,-0.025898606,-0.017556807,-0.104335986,-0.07693405,0.089351736,0.022154612,0.013846278,0.014727156,-0.016590381,0.17355546,0.020174067,-0.06005141,0.01230931,0.065308176,0.078785375,0.060762227,-0.03880639,-0.024602117,-0.026188856,-0.07336544,0.031139445,0.016765753,-0.03432408,-0.04452685,-0.09320464,-0.0654334,-0.031357493,-0.0875986,0.014241802,0.0851323,0.005319812,0.013230834,0.032301255,-0.020419415,-0.084681466,0.005391512,-0.09157185,-1.9408418e-08,0.0389562,-5.916e-05,0.06095526,0.054063443,-0.018046213,-0.016217524,0.012154801,0.09704773,0.14262012,-0.003467007,0.0032833656,0.057031482,-0.04275819,-0.054277856,-0.0033910563,0.008068616,-0.034523804,-0.10430256,0.008968171,-0.0024845283,-0.081228375,-0.041819092,-0.078432664,0.042005952,0.05601198,-0.059482314,0.075157955,0.009616161,0.044091456,-0.10283332,0.025505817,0.023723789,0.03889329,0.03494769,-0.05743349,-0.032712035,-0.003607121,-0.01112034,-0.018431751,0.054677308,-0.03678536,0.020681752,-0.1324211,-0.00011846513,-0.0018007043,0.05404202,-0.018078642,0.062027417,-0.07357587,0.020013962,-0.0021497156,-0.041028045,0.008693452,0.037209634,-0.13446006,0.022845156,0.07746568,0.02028657,0.017030537,-0.021402279,-0.010786545,-0.029678172,0.04776916,0.035002396 +1.6.5.7,"A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate.",384,1.0,-0.01312201,-0.0706053,-0.17702036,-0.03793065,0.06659074,0.047469188,-0.02683509,0.042790364,-0.0005773776,-0.112330794,0.0682107,-0.12737933,-0.045004748,-0.016229367,-0.121156186,0.04545585,-0.016521106,-0.017027898,-0.06848827,0.0046803434,0.00026535758,0.0018806206,0.033309076,0.05109806,-0.04753265,-0.015921615,0.05167763,-0.02454486,-0.07208603,-0.07369466,0.00016839079,0.054508325,0.09342099,0.0067099407,0.030972553,0.083255775,-0.03519515,-0.049057517,0.026284011,0.011918729,0.02855048,-0.04738989,0.0034897844,-0.036469284,0.053713042,0.0059881825,-0.021552414,0.08921145,0.08630676,0.03377595,-0.035113163,-0.05822299,-0.067409836,0.079071894,0.009614734,0.025986588,0.01664144,-0.012076176,-0.04805828,0.084419735,0.04932662,-0.011175895,0.021315988,-0.024130909,0.059680875,-0.019608866,-0.079454266,-0.06280137,0.024772378,-0.06424566,0.022950377,-0.015533257,-0.040044807,0.044409357,0.023035053,0.06823777,-0.027741268,0.057290524,0.033526137,-0.055780206,0.07054564,-0.022076048,0.049599454,0.09003173,0.050648123,-0.033549923,-0.022172181,0.019360567,0.02160983,0.028946042,0.079978324,0.08059011,-0.01982246,-0.044544715,-0.058038943,0.0817262,-0.04233685,-0.010482544,-0.005057836,-0.002488241,-0.04922971,-0.058769934,0.018877922,-0.030676408,-0.099816225,-0.03717862,0.06109486,0.027736763,0.05618146,-0.08440157,0.0085723,-0.057679895,0.054119304,-0.045415174,0.0054592015,0.07757264,0.0121048875,-0.080765694,-0.030340787,-0.001992117,0.0044570686,0.0436627,0.01006549,0.020634245,0.0054467293,0.043825436,-0.12072842,4.507734e-33,0.08225066,0.033714693,-0.0050370987,0.015533554,0.013788423,-0.002139233,-0.012817096,0.0057200943,0.0032187032,-0.12551576,-0.018999806,0.012629381,-0.003754451,-0.11355468,0.010254214,-0.0025577634,-0.030549048,0.0053653345,0.022527717,-0.017105784,0.08252403,0.036104564,-0.075990595,-0.048976615,0.05599294,0.032213766,-0.06535425,-0.03442135,0.008135649,0.015277145,-0.018110923,-0.040925924,-0.03351141,0.00084493565,0.010445075,0.0037851573,-0.028415475,-0.066937186,-0.11869445,0.06291651,-0.003616857,0.018263694,-0.029746298,-0.00012349951,0.041323904,-0.057280645,-0.07387199,0.08954709,0.03911997,0.05676069,0.027821722,-0.02607314,0.095576786,0.04572729,-0.041480895,-0.02225975,0.011650425,0.00055468845,0.026474718,0.015980672,-0.013449279,0.090487294,-0.038709067,0.031806678,0.0006465858,-0.022536958,-0.062177807,-0.01781221,0.044119794,0.05551727,0.03624424,-0.023927104,0.022406667,0.061067525,-0.038792178,-0.070506,-0.024479413,0.0050940933,-0.07220908,0.027156899,0.003087815,-0.05734338,0.003949877,-0.011271559,-0.09185388,0.043349408,0.006913835,-0.025050115,0.0083764335,-0.05207829,0.07851279,-0.022639956,0.029462859,-0.068880126,-0.00863341,-2.5357053e-33,0.0504238,-0.13257514,-0.032377575,0.022194587,0.00547307,0.020815842,-0.05234084,-0.017857958,0.017738461,0.0040231994,0.06009093,-0.050236363,0.021673754,-0.008530602,0.024584426,0.051706824,-0.011863144,0.12384917,0.03634627,-0.055258784,-0.014168794,0.019399516,0.043335557,0.06397545,0.041697316,0.031178601,0.015354641,0.031482417,0.019388197,0.06346106,-0.0931566,0.010116415,-0.033773825,0.009022503,0.0036143844,0.0030692862,-0.06309014,0.035738114,0.034410957,0.056596737,-0.025156446,0.024730058,0.011512529,0.02815024,-0.031913333,0.054276723,-0.014213678,0.07338908,0.072724506,9.7832184e-05,0.05831528,-0.022463705,-0.04205323,0.07287988,-0.024938181,0.057425976,0.06637443,0.04588748,-0.028225983,-0.0059957746,-0.023858285,-0.11446242,-0.02458661,-0.031896286,0.058563564,0.09565078,-0.01720466,0.14420553,0.039710604,-0.032729324,0.029027754,-0.07735747,0.09759615,0.094046496,-0.08058756,0.04178563,-0.0076206764,0.04393012,0.031383757,0.052053433,0.018042088,-0.031060811,0.020807937,-0.049813524,-0.016740436,-0.047086682,-0.0051023243,0.025581969,-0.022166064,0.006206863,-0.006429821,0.0068768505,-0.0040718927,-0.011241549,0.052608896,-3.1709163e-08,0.083789386,-0.07199108,-0.0029706778,0.0016273903,0.0641786,-0.054253627,-0.0015945564,-0.020259822,0.003503795,-0.0050065527,-0.04489961,0.050103128,-0.015260958,-0.01698922,0.05367126,0.035323203,0.06469277,0.042430792,-0.036649164,0.03267084,-0.03786898,-0.012244685,-0.08952216,0.022003114,-0.07811883,-0.024070833,0.03320698,0.06792729,0.10435249,-0.050862096,0.039325487,0.04295443,0.024512513,-0.012874602,-0.10272628,0.022622053,-0.0815179,0.0044107554,-0.11556408,0.08809606,-0.050002337,-0.05870049,0.000113201604,-0.04643006,-0.042960927,-0.087677374,0.06746084,-0.0047726287,0.04424021,-0.023980329,-0.044003036,-0.007529624,0.06169498,0.0042512105,-0.067074865,-0.0035662334,0.04853093,0.03142367,-0.0042155315,-0.060255393,-0.019385789,0.06698088,0.19620363,0.043614425 +1.6.99.1,"A flavoprotein (FMN in yeast, FAD in plants).",384,1.0,-0.04567449,-0.040424995,-0.11685085,0.044372227,0.07392589,0.039516114,0.02289192,0.06692176,0.042736564,-0.03655122,0.06068934,0.019703345,-0.11479906,-0.02024395,-0.133314,-0.00011342799,-0.052715376,-0.0097652385,-0.07802624,-0.0067482768,-0.013445726,0.040695235,0.051260713,-0.0045670257,-0.023796381,-0.06837546,-0.018864034,-0.025185566,-0.01309583,-0.08022557,0.06828843,0.12787697,0.09062199,0.024252659,-0.049564123,0.024201626,0.07542518,-0.06372796,0.0569737,0.021959942,0.03796784,-0.040108874,0.025831454,-0.031875078,0.043933786,0.044390447,0.0016942347,0.06403578,0.059549484,0.06909659,-0.025277017,-0.04886968,-0.057906445,0.038890455,0.030397128,0.03450877,-0.012394205,-0.030693976,-0.035022013,0.0696159,-0.031965658,-0.005829135,0.026382012,0.007860975,0.050916173,-0.07420497,-0.052432448,0.01572897,0.07417905,0.011058706,0.04571142,-0.012046803,-0.08022975,0.041529138,0.006691481,0.12586504,-0.01794264,-0.030016357,0.036299672,-0.0026322354,0.06504684,0.015618059,0.06551198,0.05549065,0.042087667,-0.08974313,-0.027583783,0.039530866,-0.024493398,0.08193637,-0.012618519,0.049023096,0.009481689,0.02430751,-0.04102717,0.09154783,0.06329834,-0.02930104,-0.079909585,-0.0056707375,-0.037149135,-0.04763928,0.074758545,-0.0009250815,-0.06532568,0.0049682027,-0.014502264,-0.0022715887,0.020399818,-0.056239866,-0.001728454,-0.014378983,0.007036646,-0.122760326,0.0074934424,-0.021328926,-0.0009743771,-0.050647993,-0.013075039,-0.0033811913,-0.06703362,0.091625966,0.004477711,0.08161206,-0.0065948674,-0.006897292,-0.09908252,-8.210944e-34,0.03725526,0.024654891,-0.042635147,0.016273424,0.031053418,-0.03688361,0.0071890852,-0.022296144,0.0099050645,-0.05561021,-0.075912826,0.004087583,-0.02068129,-0.03833686,0.016666433,-0.0039764186,0.009269581,-0.052736804,0.052596428,-0.044987414,0.009408865,0.011570953,-0.031183077,-0.003677815,0.043130934,-0.01607953,-0.038412634,-0.030923577,-0.00014628423,-0.0016466535,0.0028253996,-0.07216194,-0.0009633666,0.028983891,0.009767432,0.012195242,-0.033713054,-0.071681164,-0.117394485,0.060106713,0.00041409617,-0.013789961,-0.030256059,0.014810816,0.027411371,0.030202152,-0.09749718,0.055481307,0.014397327,0.119585745,0.022914357,-0.027562171,0.11560135,0.08535726,-0.04546681,0.009484756,-0.03147011,0.03539789,0.008311691,0.01278414,-0.04846379,0.07110245,-0.029942846,0.06819139,-0.041948408,-0.0035688935,-0.071205296,-0.037823293,0.038612522,0.07823354,0.022134535,-0.03474977,0.05442527,-0.01766892,0.051550716,-0.01915725,-0.06824304,-0.025863599,-0.06169375,0.059171304,-0.0014811704,-0.075205125,-0.05082428,0.00012455731,-0.102412716,0.049389996,0.008498945,-0.0044748257,0.00077480805,-0.054872196,0.073077336,-0.045757588,0.016730007,-0.007815071,0.022335062,-1.5396521e-35,0.039860457,-0.09459594,0.0042776614,0.06427493,-0.030736446,0.051275,-0.008391502,-0.062163733,-0.05590603,-0.018737525,0.0034114753,-0.12862869,-0.018008461,-0.021147901,-0.0018088041,0.02200889,-0.025291815,0.09690392,0.044361286,0.056449085,-0.11128709,0.012889869,0.032914642,0.12700504,0.051416837,0.004583934,0.070566356,-0.0055715395,-0.041431636,0.018332893,-0.045972884,0.021095304,-0.055819675,-0.05783606,0.0047561787,0.0062914607,-0.0070693553,-0.049828958,-0.00474258,0.023070898,0.0065963403,0.069178246,0.029819157,0.050708264,0.03652996,0.097171284,-0.029611621,0.06006612,0.05978395,0.0035753057,-0.0051268185,0.030254088,-0.015551458,0.08941441,0.02527886,-0.0059694336,0.08017424,0.089679316,0.00726751,0.017779542,0.0067500253,-0.1262274,-0.019801974,-0.026732681,0.046435185,0.06798342,0.007529563,0.094114974,0.00629541,0.035868023,0.093858115,0.008805321,0.07933495,0.085508704,0.0075357594,0.027119651,-0.008599522,0.040292766,-0.040439088,0.020231381,-0.016422909,-0.03035445,-0.0041939346,-0.022323336,-0.040926907,-0.10856132,0.01424905,0.038627766,0.006187722,0.021245236,0.01026932,0.03131018,-0.07338424,-0.06011586,0.045329757,-1.9365006e-08,0.04585245,-0.05780209,-0.015804308,-0.044609133,0.0896617,-0.0067791725,0.023634922,0.018723043,-0.031595174,0.026445653,-0.072578534,0.11418289,-0.015428308,0.012584593,0.07481366,-0.06660199,0.021369237,0.032725718,-0.017822435,-0.018914621,-0.075721145,0.050347358,-0.09053799,0.016963538,-0.069735646,-0.04375122,0.035524838,0.015163081,0.11354947,-0.05328161,0.046648398,0.042199817,0.006905741,-0.07263565,-0.1436603,0.02457504,0.015114705,-0.06602911,-0.06463644,0.036543418,-0.10375362,-0.023897974,-0.012001408,-0.06785075,-0.060199887,-0.060883082,0.08658198,0.04777252,-0.009511134,-0.040678818,0.026129797,0.011307462,-0.01975448,-0.019094154,-0.07413114,-0.035116658,0.0052842884,-0.027482208,-0.025324438,-0.09222399,-0.05409545,0.01449953,0.10242984,-0.0063530654 +1.6.99.3,"A flavoprotein containing iron-sulfur centres. After preparations have been subjected to certain treatments, cytochrome c may act as an acceptor. Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. Present in a mitochondrial complex as EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating).",384,0.99999994,-0.08608023,0.018035337,-0.1204096,0.089167304,0.021358225,0.041075215,0.019797316,0.056264948,0.020756437,-0.08128095,0.08449297,-0.0067968173,0.0004540222,-0.022280592,-0.049140655,0.0051386175,-0.05170118,-0.0030628534,-0.056146648,0.017341333,-0.061476246,-0.042651013,0.07059802,-0.029489229,-0.008740901,0.00028443278,-0.011059501,0.03390952,-0.050900497,-0.077415325,0.014465928,0.008097965,0.017261604,0.030225687,-0.025673557,0.082786664,-0.061537463,-0.051354207,-0.06543669,-0.057909343,0.05400409,-0.00681217,-0.014722338,0.095136754,0.04052879,-0.0008896397,0.0032473544,0.0658311,0.014725893,0.0015741576,-0.011193748,-0.0072599105,-0.08694324,0.13464707,0.014619477,0.059506327,-0.04903978,-0.066618524,-0.0076145907,-0.00059328985,0.031191729,0.001840008,0.011377668,0.0048529366,0.039333727,-0.09225518,0.037966955,-0.038962636,0.058746856,-0.044253998,0.017750567,-0.06543424,-0.11413582,0.031525064,-0.051127087,0.050914668,-0.04228814,-0.028670609,0.05840756,0.023113994,0.010335879,-0.031171164,-0.00080680684,0.06840283,0.07132732,-0.015004668,-0.06142162,-0.022989716,-0.08084683,0.07376357,-0.010551435,-0.013049566,-0.011453934,0.019220114,-0.10081016,-0.0062563885,0.1014199,0.075284615,-0.035245728,0.0067344764,0.0343365,0.0518902,0.046066046,-0.07009842,-0.043766964,-0.05140092,-0.04887321,0.06421826,-0.0189548,-0.050751965,-0.03489469,-0.1073848,-0.01871215,-0.10001949,0.0281541,0.107235596,0.08115615,0.005447877,-0.03604359,0.00861987,-0.024822205,0.1153084,0.02620489,-0.003171962,0.030780561,-0.083928816,-0.13700204,1.6193449e-33,0.046802618,-0.009592874,-0.004498627,0.057143707,-0.05216238,0.048981775,-0.06964822,0.017442347,0.008779781,-0.023575732,-0.05709735,0.02735094,0.04503178,-0.0118259555,5.6537916e-05,-0.015206728,-0.055025958,0.006380264,0.076824345,-0.05915936,0.017308459,0.059154887,-0.007403303,-0.09550571,0.035437204,0.009606714,-0.09506307,-0.019410487,0.008120241,0.04163796,0.028176893,-0.050456,-0.10936052,0.023975596,0.005187863,0.022412734,-0.085996024,-0.06914563,-0.023118196,0.031614542,-0.08438555,-0.03940473,-0.027054666,-0.00957069,0.06429861,-0.058259733,-0.06350467,0.063493215,-0.02329857,0.04411515,0.060015388,-0.08206829,0.12009977,0.03390544,-0.06679929,0.08016266,0.021635838,0.03138882,-0.04308274,0.06926695,0.08013953,0.10655192,-0.05393513,0.08878731,0.022124566,-0.001285289,-0.09319471,-0.007636422,-0.04248411,0.06790471,-0.004826452,-0.016659478,0.13321485,0.00092811394,0.018120993,0.038499724,-0.09783714,-0.021251846,-0.024579756,0.033578426,-0.08656359,-0.07623631,-0.03324318,0.026318995,-0.01548127,0.065119244,0.031329248,-0.036708158,-0.016914967,0.022025239,0.03796567,-0.0038596536,-0.030274425,-0.045228086,0.06962534,-3.7277266e-33,0.046933386,-0.045664165,-0.014169706,-0.05342497,0.039516144,0.047127053,0.017281292,-0.053041894,-0.015595827,0.007913692,0.023385663,-0.05535228,-0.027162513,-0.019962471,0.03634146,-0.02327809,-0.04370876,0.10603027,0.027107012,0.04387055,-0.030207355,-0.034367826,0.011965415,0.036672425,0.029989727,-0.035644904,0.022011278,-0.05636244,0.07094536,0.017869828,-0.06955443,-0.0062831356,-0.06025954,-0.050017808,0.028476989,0.051082373,-0.036736675,0.0063540144,0.0685077,0.040114798,0.00031908596,0.0013296981,-0.027909651,0.05394499,0.091701284,0.052262604,-0.0775222,0.075818524,0.039069913,-0.021540884,0.06687864,0.015239663,-0.04129275,0.08000523,0.026101813,0.08236396,-0.0027142595,0.008080742,0.051194273,0.0018805771,-0.04280001,-0.10340526,-0.026927134,-0.020909604,-0.0011887983,0.00739258,0.03710354,0.03360595,-0.033407073,-0.022805026,0.10649048,-0.040286012,-0.005856957,0.0071297754,0.016451769,-0.03637543,0.021609493,0.04850549,-0.001318621,-0.021534918,-0.0007785295,-0.018588597,0.0380385,-0.019439342,0.06754427,-0.14179751,-0.050050955,0.008648691,0.0071878484,-0.04910715,0.02299986,0.03554994,-0.05318377,-0.0035630055,-0.023121566,-3.8056964e-08,0.042614795,-0.026919955,0.035956983,-0.031734835,0.11366129,0.0068072095,-0.026570853,-0.052361403,-0.018916167,0.04001087,0.048612624,0.12603657,0.015059042,-0.07014784,0.050614312,0.060337525,0.0058462494,0.012070835,0.018720083,-0.0039292467,-0.040242318,-0.024449049,-0.08182075,0.027748939,-0.028611308,-0.015255887,0.007978849,-0.0021848788,0.03093591,-0.0340218,0.11290553,0.046570856,0.03953791,-0.016199412,-0.07217533,-0.03040545,0.007534353,-0.05546711,-0.05570922,0.030319987,-0.069577195,-0.051968243,-0.05068998,0.034915633,0.041036993,-0.0319948,0.045562193,0.058611162,-0.0573386,0.0060502626,-0.024022525,0.0069228327,0.01573949,-0.05394266,-0.05399016,0.042612597,0.054529212,-0.04724142,-0.021140179,-0.086516105,0.047842808,0.047461133,0.10394142,0.022801874 +1.6.99.5,"Menaquinone can act as acceptor. Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives.",384,0.99999994,-0.029463084,-0.04176969,-0.11876462,-0.004798976,-0.07154791,-0.000874984,-0.00085232186,-0.015785271,0.039381877,0.038197666,0.01626278,0.02433999,-0.024635358,0.083967656,-0.0058102757,0.021095837,0.008226189,0.010445388,0.015854053,0.07455797,-0.02048591,-0.012175191,-0.03253368,-0.100193724,-0.040104643,0.007926458,-0.051276375,0.08024704,0.0028854713,-0.04276673,0.010420557,0.028123336,0.060115587,0.027473597,-0.11393455,-0.005880246,-0.08829773,0.0046593132,-0.010003617,0.082137965,0.0010145282,-0.019990327,0.0076912823,0.0039030293,0.032344256,-0.06581086,-0.0673397,0.02712602,0.042351227,0.0717318,-0.04234809,0.026772218,0.038744498,0.08169293,-0.022661407,-0.045174085,-0.07283503,0.023701638,0.026865287,0.005761463,-0.0011711153,-0.04658812,-0.0069646286,-0.0052396096,0.002530663,0.007950689,-0.09822983,-0.067669965,0.011367541,0.059696365,0.09244503,-0.060458012,-0.012029789,-0.0688776,0.04264122,0.066470444,-0.07622732,-0.010574223,0.06471452,-0.030133422,0.018621432,0.03449591,-0.018162427,0.13060525,0.025164194,0.03551512,-0.03558409,-0.0032902625,-0.03496448,0.080208726,-0.009183289,-0.031795193,0.029273817,-0.0627746,0.012865793,-0.05783097,-0.004489301,0.050392285,-0.10740576,-0.020529551,0.020510143,0.013566573,-0.14368558,-0.08049624,-0.089806,0.0426611,0.064846925,-0.014366293,-0.047382746,-0.012218443,-0.10015494,0.022423008,-0.03137015,0.023993215,-0.028220167,0.021860017,0.0964556,-0.073087275,-0.06703768,-0.020173417,-0.039923117,-0.047111668,0.04624049,-0.034914214,0.01888692,0.046265315,0.015198846,1.5134077e-33,-0.03660999,0.02574633,-0.008030182,-0.013571469,0.017892558,0.01105257,-0.03375418,0.0009104114,0.011159122,-0.0951262,-0.037159927,0.03677185,-0.023507653,0.03634628,-0.0032816096,-0.02874333,0.046431188,-0.04207827,0.076693244,-0.070806764,0.08883463,0.077814944,-0.07040633,-0.013262249,-0.052024577,0.03489476,-0.023684915,0.08402192,0.040909488,0.015205136,0.01508901,-0.0055171545,-0.017930498,0.0007662654,0.0037238244,0.03504992,-0.015642043,0.03819133,-0.044412155,0.0034618375,-0.00051920547,-0.004613798,-0.14879021,0.044058926,0.077018276,-0.049531788,-0.05261095,0.0026327476,1.6668964e-05,0.0069879643,-0.015555283,0.0263806,0.00885321,-0.06687069,-0.013325018,-0.014336239,0.0052687274,0.035218917,-0.011053638,0.057431772,-0.008867019,0.014244263,0.0053580236,0.029508876,-0.08283196,-0.015399378,-0.0058974517,-0.098267674,-0.07024871,-0.00013304222,0.022682568,0.008184529,0.048919834,0.05356047,0.04646907,-0.04417113,-0.011221151,0.07853154,0.043821268,-0.046701185,-0.009553396,-0.08015993,-0.030370014,0.10838573,-0.0687252,0.01588573,0.054720808,-0.06775862,0.011691052,-0.04318827,0.030378168,-0.027721379,-0.03877181,0.016356392,0.11787782,-3.6109603e-33,0.07305598,-0.026932776,0.04866805,-0.01084284,-0.008631839,0.118984856,0.020316496,-0.04501943,0.064091444,-0.013899479,0.10531174,-0.019841516,0.031740647,-0.012151334,-0.06928066,-0.038872156,0.022898471,0.027993716,-0.072275065,-0.015703827,-0.029359896,0.03973876,0.090116516,0.034776855,-0.010788799,0.045666784,0.03768641,0.022657318,-0.008605391,0.13633338,-0.003910942,0.034944184,-0.05570819,-0.11456781,0.05559316,-0.012344549,-0.10978736,0.049667105,-0.0570615,-0.009979942,-0.0073568835,0.010367912,-0.012023326,0.06631837,0.08896613,0.042464938,0.010187897,0.039754815,-0.036232345,-0.045019187,0.021125715,0.025293728,-0.054213267,0.03244238,0.11906833,0.053774823,0.08643593,-0.11246583,0.021044292,0.013855498,-0.08871283,0.009250514,-0.020178622,-0.049521763,0.049193893,0.009665607,0.0021125318,0.08906479,0.11147108,-0.028729035,0.087944455,-0.12045252,0.09796843,0.070257016,-0.041649744,0.03502062,0.008360164,-0.056753825,0.029020673,-0.039801195,-0.08563378,-0.008158866,-0.0043541947,-0.023613794,-0.06407942,-0.060549024,-0.0011405121,-0.031557422,-0.07940029,0.124406725,-0.0026134625,0.020555157,-0.035424713,-0.019240025,0.03908362,-3.1046206e-08,0.07326177,-0.019759709,0.0703132,-0.035651717,-0.024195869,-0.04288711,-0.06912421,-0.043289747,0.08071475,0.049171813,0.0022998576,0.06481814,0.050333753,-0.01624803,0.01338837,0.033676285,0.07041861,0.025274908,-0.021236463,-0.031188143,-0.12744503,-0.014715894,-0.014673973,-0.08203547,-0.018460862,-0.037549876,-0.009458688,-0.043684904,-0.0094266385,0.016688518,0.03208025,0.029033938,0.032635067,-0.035387266,-0.00943186,0.07868596,0.030414745,0.011399763,0.018602202,-0.039304473,-0.017760376,-0.041756768,-0.0031541479,0.029096544,-0.061930675,0.023722174,0.04752075,0.025635505,-0.05454623,0.00962002,-0.013956339,0.002991985,0.07203214,-0.085311644,-0.08859757,0.047372956,-0.042463113,-0.035662293,0.020481747,-0.112568416,-0.037889052,-0.00023969538,0.05742228,0.041289236 +1.6.99.6,"A flavoprotein. Menaquinone can act as acceptor. Inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.",384,1.0,-0.051502503,-0.04842774,-0.13665006,0.031238927,-0.013009982,0.022944363,0.004932585,-0.016483326,0.048666175,0.0010281779,0.0018861268,0.052541167,-0.06585767,0.05611612,-0.032399323,0.019545216,-0.02274136,0.01817749,-0.00325698,0.05005101,-0.05852747,-0.03567492,-0.018753795,-0.082340375,-0.042487957,-0.0096658105,-0.03223184,0.044715278,-0.017783448,-0.022671377,0.048055798,0.05394632,0.07319469,0.032410543,-0.11032979,-0.02391379,-0.05701455,-0.028040579,-0.012523571,0.04107261,0.012883644,-0.02442651,0.030236704,0.01884342,0.0713853,-0.039272375,-0.061999522,0.06693885,0.051954176,0.09105591,-0.067763135,0.041200418,-0.02838344,0.070714556,-0.006514676,-0.020809505,-0.039288554,-0.012304395,0.00052622,0.02348599,0.003488282,-0.059726797,0.038889356,0.006801234,0.006766499,-0.039828952,-0.08728518,-0.04617505,0.03729513,0.040013198,0.08979211,-0.027486667,-0.057664063,-0.0012127558,0.029936355,0.087604195,-0.094598256,0.0035733855,0.082152165,-0.030667344,0.030770298,0.015482478,0.024286972,0.14802411,0.032045197,0.015275884,-0.06086617,0.0034271907,-0.025867544,0.1038691,-0.011781538,-0.010282258,0.03698114,-0.02318224,-0.013570062,-0.01844098,0.034166355,0.0017242869,-0.14453863,-0.010737296,-0.0155274905,-0.037509248,-0.08092465,-0.062468007,-0.099099934,0.04398855,0.034669954,-0.034167938,-0.029132143,-0.046949398,-0.09176743,-0.023372231,-0.014550631,-0.035492368,0.00080483913,-0.006173666,0.07820572,-0.059936,-0.058619406,-0.004393407,-0.046350446,0.035397723,0.074987665,-0.0031472535,0.017617568,0.035443433,-0.0016294597,2.3622198e-33,-0.022805095,0.024645792,-0.010801954,0.016678942,0.00894673,0.004573662,-0.0076012504,-0.0033594524,0.0145740695,-0.07369369,-0.03293241,0.02862351,-0.019142235,-0.0012850133,0.051590003,-0.010861162,0.06487524,-0.046544343,0.075368345,-0.07705035,0.06386244,0.0600664,-0.057555005,-0.016414288,-0.0016927031,0.015472405,-0.047167085,0.028971588,0.051921334,0.022872109,-0.011921303,-0.013212257,-0.031860854,0.005281939,0.013023478,0.025798973,-0.03456992,-0.014044528,-0.0811395,0.03189787,-0.0065159444,-0.04362222,-0.14257018,0.026482398,0.05339627,-0.021355188,-0.07326064,0.039061774,-0.029354574,-0.0035004201,0.008153525,0.009382034,0.04255302,-0.014218828,-0.028288437,0.0004311237,0.019876843,0.043127052,-0.0040345173,0.018659433,-0.010042096,-0.004414831,-0.012477134,0.045383498,-0.07458834,-0.026903737,-0.019068722,-0.09513953,-0.057159368,0.029981244,0.054048534,0.026509002,0.067988746,0.05613751,0.057824463,-0.04042499,-0.049850788,0.050670348,0.019938732,-0.017304238,-0.024466017,-0.081980765,-0.035633013,0.09657485,-0.059020292,0.041351825,0.049024854,-0.053904425,0.023725942,-0.049977604,0.04104395,-0.050096776,-0.021049466,0.013265072,0.11020984,-3.4133167e-33,0.0425902,-0.0700357,0.013873269,0.040492274,-0.008978859,0.081660695,0.00905511,-0.06585954,0.054247227,-0.023258353,0.08043859,-0.07993609,6.171405e-05,-0.026071861,-0.046725817,-0.020148328,0.0014946425,0.065889165,-0.04152509,-0.020440409,-0.02861259,-0.015364855,0.09402782,0.065914884,-0.013925968,0.022228751,0.03636702,-0.012366498,-0.00831692,0.13966538,-0.038210098,0.046130594,-0.052220948,-0.110639736,0.053168196,-0.00023263291,-0.09287554,0.01815225,-0.03306633,0.020612672,0.016932936,0.025194742,-0.0045502232,0.043216396,0.0968144,0.06785825,0.001389869,0.07724721,0.009475065,-0.04248743,0.034675766,0.039117143,-0.056540474,0.07965292,0.12284372,0.058819134,0.11133979,-0.08405222,0.03269656,0.019838138,-0.09645218,-0.053508855,-0.01641695,-0.009798757,0.08296162,0.051071227,0.02041853,0.13120088,0.07006263,-0.04289924,0.10862038,-0.1258492,0.123701476,0.11212914,0.010188091,0.02737806,0.026812114,0.011013286,0.012362937,-0.009118668,-0.069520384,-0.0431809,0.00544849,-0.010187037,-0.06432449,-0.1059057,-0.014335157,-0.050257742,-0.063625105,0.09847257,-0.0035886716,0.044709403,-0.036728796,-0.041157573,0.027541352,-3.0948158e-08,0.06379225,-0.01617048,0.047697335,-0.025635224,0.035898577,-0.037947293,-0.08392861,-0.028028913,0.078084715,0.036432896,-0.01925224,0.07338278,0.02805854,-0.030835422,0.017462434,0.013037334,0.06906609,0.0036794755,-0.011980957,-0.03864882,-0.10298872,0.005079347,-0.04030248,-0.0652339,-0.06405812,-0.043623693,-0.035225596,-0.051539995,0.0654741,-0.0064666225,0.030029299,0.035404745,0.05094526,-0.028574875,-0.07128687,0.047103055,0.033605315,-0.015192233,0.02788657,0.00086451607,-0.06455647,-0.021769231,-0.007920509,-0.022019643,-0.033795297,0.02347342,0.058917385,0.019828772,-0.07040846,-0.011417428,-0.03724691,0.03815197,0.051228005,-0.03704708,-0.07861095,0.019743893,-0.014048978,-0.022030171,0.009596784,-0.14665738,-0.06557403,0.012336817,0.076588444,0.059593063 +1.7.1.1,An iron-sulfur molybdenum flavoprotein.,384,1.0,-0.048515577,-0.049284626,-0.1409859,0.100148514,0.052892797,-0.016475504,0.029839464,-0.0067990758,0.0298131,-0.13116929,0.0071055945,0.075774826,-0.012841348,-0.03637378,-0.11747973,0.00822416,0.0074621355,0.00421405,-0.037804265,0.04044412,-0.042026002,0.017205384,0.04931658,-0.051950656,-0.04774001,0.044518363,0.017258007,0.0046336227,-0.060924,-0.031964593,0.05086096,0.066980295,0.01978337,-0.00586911,-7.844924e-05,0.027279604,0.0048660934,-0.008386635,-0.026341438,-0.020213654,0.024463352,-0.010288838,0.0349591,-0.024110211,0.018128566,-0.042711195,-0.01277226,0.031402573,0.021217812,0.090399586,-0.010724294,-0.07307884,-0.102854244,0.07200094,0.028085997,-0.015975736,-0.03328357,0.010536234,0.0073228804,0.012679164,-0.026915297,0.016703675,0.09315106,-0.00054374133,0.011148116,-0.06673627,0.036950815,-0.061938275,0.0470744,-0.061053585,0.008184187,0.049185645,-0.0532933,0.09521929,-0.029297652,0.11125877,0.002975086,-0.012812299,0.14728786,-0.009348214,0.017996486,-0.004119051,0.036895365,0.09024659,0.04416665,-0.028463554,-0.047499426,-0.00672419,-0.046811484,0.027268196,-0.002108694,0.015892062,0.014978442,0.055714414,-0.06606997,0.010014333,0.05127781,0.028621169,-0.16439983,0.028606193,-0.07567582,-0.030037783,0.027649038,-0.03349207,-0.06220048,-0.06237759,-0.006671487,0.0503363,-0.008572484,-0.03353502,0.00826552,-0.01424862,0.05059876,-0.090794556,0.07046636,-0.0075834882,0.049747672,0.03405193,-0.05333592,-0.009025263,-0.01310682,0.123012364,-0.0028670505,0.028446944,-0.032336924,0.014058823,-0.06902035,1.0227848e-33,0.11888724,0.05231327,0.08414213,0.039744806,-0.029043967,-0.0062255575,-0.042744536,-0.011756232,0.016255772,-0.023537217,-0.04149008,-0.05478491,0.037304085,-0.07650548,0.045490455,0.0067903087,-0.026090752,-0.08376091,0.088349804,-0.05271049,-0.028189281,0.07523466,0.010359093,0.0025303408,0.019834742,0.019768331,-0.035529524,-0.029897664,-0.003940278,0.053564716,0.027935017,-0.07149453,-0.08932448,-0.04124758,0.014665366,-0.009730196,-0.05282774,-0.07256154,-0.086151,0.0104548,-0.03630555,-0.03499438,-0.04605475,-0.025167005,0.007345575,-0.0046188706,-0.0705469,0.13487831,0.021404026,0.032133844,-0.021439275,-0.042664535,0.08313771,0.0874908,-0.12516116,0.031851508,0.010408612,0.0071067577,-0.01140597,0.05722607,0.0049989494,0.07245389,0.029005244,0.061451744,-0.062168397,-0.047691617,-0.103571504,-0.012196869,0.003941429,0.06696137,0.04991491,0.040449206,0.08985155,-0.014617583,-0.022741737,-0.027531212,0.0028087895,-0.08984631,0.0063214884,0.04218908,-0.041889526,-0.03180287,0.030235847,-0.013673276,-0.050524823,0.06635627,-0.051491905,-0.011540025,0.012335423,0.0024203556,0.02272008,0.011846719,-0.048549753,-0.03782906,-0.05090042,-1.4714412e-33,0.017867183,-0.0861928,0.01870978,0.053314943,-0.017778957,-0.02612082,-0.011679334,-0.038854294,-0.031592764,0.0066220416,0.046887383,-0.06615822,-0.0027983186,-0.062686615,0.06471154,0.083687685,-0.013556612,0.078427225,0.0864797,0.004723241,-0.04637776,-0.0373662,0.019821657,0.038266197,0.019405348,0.0044046603,0.038564004,-0.08058747,0.030115418,0.055981632,0.0038646506,0.03323947,-0.06652168,-0.12088548,-0.04585091,0.007440447,0.010698602,-0.045318842,0.027612628,-0.014457077,-0.04787135,-0.0020218277,0.052208714,0.1124886,0.109140344,0.055492945,0.007701094,0.080174856,0.07313065,0.059362557,-0.012442154,-0.014137974,-0.0053840657,0.12917599,0.023561677,0.026934061,0.025206368,0.0671916,-0.016805213,0.047706265,-0.023993308,-0.055747483,-0.01819423,-0.00019868115,0.038063843,0.14088611,0.0449697,0.060207818,0.04847218,-0.07000745,0.052066237,-0.04979406,0.0071062096,0.015365151,0.07943073,-0.013346966,-0.013998155,0.1473057,-0.05887705,0.04928022,-0.025016824,0.010863267,0.025841286,-0.048156094,0.043767396,-0.12181364,-0.01701502,0.080871776,0.014884782,0.012175695,-0.07830988,0.0037697013,-0.06884574,-0.07736049,-0.022306021,-1.9489423e-08,-0.0331745,-0.08365946,-0.0072252075,-0.06204272,0.058997568,0.06750513,-0.007000923,-0.03400334,-0.03009042,0.014272798,0.02862188,0.09608977,-0.012869221,-0.034464475,-9.9863464e-05,0.03140988,-0.010801023,-0.0058624707,0.009650841,-0.01713732,-0.0124828,-0.030401202,-0.04116342,0.08526584,-0.047080293,-0.026647095,-0.033105083,-0.045292173,0.026255006,-0.017685594,0.03044616,0.030908285,-0.013713474,-0.06835841,-0.10293436,-0.0028803197,0.018910075,-0.030333793,-0.0035769283,0.047477916,-0.11109211,0.01298881,0.019496761,-0.0048241923,0.039980706,-0.047494937,-0.0054443846,0.054871563,-0.039911143,-0.029603219,-0.026239714,-0.02030655,0.0022487883,-0.0019165179,-0.06958734,0.047094826,0.06418447,-0.05964354,0.008878651,-0.03884944,-0.037133276,-0.0401658,0.05160534,0.01668734 +1.7.1.2,An iron-sulfur molybdenum flavoprotein.,384,1.0,-0.048515577,-0.049284626,-0.1409859,0.100148514,0.052892797,-0.016475504,0.029839464,-0.0067990758,0.0298131,-0.13116929,0.0071055945,0.075774826,-0.012841348,-0.03637378,-0.11747973,0.00822416,0.0074621355,0.00421405,-0.037804265,0.04044412,-0.042026002,0.017205384,0.04931658,-0.051950656,-0.04774001,0.044518363,0.017258007,0.0046336227,-0.060924,-0.031964593,0.05086096,0.066980295,0.01978337,-0.00586911,-7.844924e-05,0.027279604,0.0048660934,-0.008386635,-0.026341438,-0.020213654,0.024463352,-0.010288838,0.0349591,-0.024110211,0.018128566,-0.042711195,-0.01277226,0.031402573,0.021217812,0.090399586,-0.010724294,-0.07307884,-0.102854244,0.07200094,0.028085997,-0.015975736,-0.03328357,0.010536234,0.0073228804,0.012679164,-0.026915297,0.016703675,0.09315106,-0.00054374133,0.011148116,-0.06673627,0.036950815,-0.061938275,0.0470744,-0.061053585,0.008184187,0.049185645,-0.0532933,0.09521929,-0.029297652,0.11125877,0.002975086,-0.012812299,0.14728786,-0.009348214,0.017996486,-0.004119051,0.036895365,0.09024659,0.04416665,-0.028463554,-0.047499426,-0.00672419,-0.046811484,0.027268196,-0.002108694,0.015892062,0.014978442,0.055714414,-0.06606997,0.010014333,0.05127781,0.028621169,-0.16439983,0.028606193,-0.07567582,-0.030037783,0.027649038,-0.03349207,-0.06220048,-0.06237759,-0.006671487,0.0503363,-0.008572484,-0.03353502,0.00826552,-0.01424862,0.05059876,-0.090794556,0.07046636,-0.0075834882,0.049747672,0.03405193,-0.05333592,-0.009025263,-0.01310682,0.123012364,-0.0028670505,0.028446944,-0.032336924,0.014058823,-0.06902035,1.0227848e-33,0.11888724,0.05231327,0.08414213,0.039744806,-0.029043967,-0.0062255575,-0.042744536,-0.011756232,0.016255772,-0.023537217,-0.04149008,-0.05478491,0.037304085,-0.07650548,0.045490455,0.0067903087,-0.026090752,-0.08376091,0.088349804,-0.05271049,-0.028189281,0.07523466,0.010359093,0.0025303408,0.019834742,0.019768331,-0.035529524,-0.029897664,-0.003940278,0.053564716,0.027935017,-0.07149453,-0.08932448,-0.04124758,0.014665366,-0.009730196,-0.05282774,-0.07256154,-0.086151,0.0104548,-0.03630555,-0.03499438,-0.04605475,-0.025167005,0.007345575,-0.0046188706,-0.0705469,0.13487831,0.021404026,0.032133844,-0.021439275,-0.042664535,0.08313771,0.0874908,-0.12516116,0.031851508,0.010408612,0.0071067577,-0.01140597,0.05722607,0.0049989494,0.07245389,0.029005244,0.061451744,-0.062168397,-0.047691617,-0.103571504,-0.012196869,0.003941429,0.06696137,0.04991491,0.040449206,0.08985155,-0.014617583,-0.022741737,-0.027531212,0.0028087895,-0.08984631,0.0063214884,0.04218908,-0.041889526,-0.03180287,0.030235847,-0.013673276,-0.050524823,0.06635627,-0.051491905,-0.011540025,0.012335423,0.0024203556,0.02272008,0.011846719,-0.048549753,-0.03782906,-0.05090042,-1.4714412e-33,0.017867183,-0.0861928,0.01870978,0.053314943,-0.017778957,-0.02612082,-0.011679334,-0.038854294,-0.031592764,0.0066220416,0.046887383,-0.06615822,-0.0027983186,-0.062686615,0.06471154,0.083687685,-0.013556612,0.078427225,0.0864797,0.004723241,-0.04637776,-0.0373662,0.019821657,0.038266197,0.019405348,0.0044046603,0.038564004,-0.08058747,0.030115418,0.055981632,0.0038646506,0.03323947,-0.06652168,-0.12088548,-0.04585091,0.007440447,0.010698602,-0.045318842,0.027612628,-0.014457077,-0.04787135,-0.0020218277,0.052208714,0.1124886,0.109140344,0.055492945,0.007701094,0.080174856,0.07313065,0.059362557,-0.012442154,-0.014137974,-0.0053840657,0.12917599,0.023561677,0.026934061,0.025206368,0.0671916,-0.016805213,0.047706265,-0.023993308,-0.055747483,-0.01819423,-0.00019868115,0.038063843,0.14088611,0.0449697,0.060207818,0.04847218,-0.07000745,0.052066237,-0.04979406,0.0071062096,0.015365151,0.07943073,-0.013346966,-0.013998155,0.1473057,-0.05887705,0.04928022,-0.025016824,0.010863267,0.025841286,-0.048156094,0.043767396,-0.12181364,-0.01701502,0.080871776,0.014884782,0.012175695,-0.07830988,0.0037697013,-0.06884574,-0.07736049,-0.022306021,-1.9489423e-08,-0.0331745,-0.08365946,-0.0072252075,-0.06204272,0.058997568,0.06750513,-0.007000923,-0.03400334,-0.03009042,0.014272798,0.02862188,0.09608977,-0.012869221,-0.034464475,-9.9863464e-05,0.03140988,-0.010801023,-0.0058624707,0.009650841,-0.01713732,-0.0124828,-0.030401202,-0.04116342,0.08526584,-0.047080293,-0.026647095,-0.033105083,-0.045292173,0.026255006,-0.017685594,0.03044616,0.030908285,-0.013713474,-0.06835841,-0.10293436,-0.0028803197,0.018910075,-0.030333793,-0.0035769283,0.047477916,-0.11109211,0.01298881,0.019496761,-0.0048241923,0.039980706,-0.047494937,-0.0054443846,0.054871563,-0.039911143,-0.029603219,-0.026239714,-0.02030655,0.0022487883,-0.0019165179,-0.06958734,0.047094826,0.06418447,-0.05964354,0.008878651,-0.03884944,-0.037133276,-0.0401658,0.05160534,0.01668734 +1.7.1.3,An iron-sulfur molybdenum flavoprotein.,384,1.0,-0.048515577,-0.049284626,-0.1409859,0.100148514,0.052892797,-0.016475504,0.029839464,-0.0067990758,0.0298131,-0.13116929,0.0071055945,0.075774826,-0.012841348,-0.03637378,-0.11747973,0.00822416,0.0074621355,0.00421405,-0.037804265,0.04044412,-0.042026002,0.017205384,0.04931658,-0.051950656,-0.04774001,0.044518363,0.017258007,0.0046336227,-0.060924,-0.031964593,0.05086096,0.066980295,0.01978337,-0.00586911,-7.844924e-05,0.027279604,0.0048660934,-0.008386635,-0.026341438,-0.020213654,0.024463352,-0.010288838,0.0349591,-0.024110211,0.018128566,-0.042711195,-0.01277226,0.031402573,0.021217812,0.090399586,-0.010724294,-0.07307884,-0.102854244,0.07200094,0.028085997,-0.015975736,-0.03328357,0.010536234,0.0073228804,0.012679164,-0.026915297,0.016703675,0.09315106,-0.00054374133,0.011148116,-0.06673627,0.036950815,-0.061938275,0.0470744,-0.061053585,0.008184187,0.049185645,-0.0532933,0.09521929,-0.029297652,0.11125877,0.002975086,-0.012812299,0.14728786,-0.009348214,0.017996486,-0.004119051,0.036895365,0.09024659,0.04416665,-0.028463554,-0.047499426,-0.00672419,-0.046811484,0.027268196,-0.002108694,0.015892062,0.014978442,0.055714414,-0.06606997,0.010014333,0.05127781,0.028621169,-0.16439983,0.028606193,-0.07567582,-0.030037783,0.027649038,-0.03349207,-0.06220048,-0.06237759,-0.006671487,0.0503363,-0.008572484,-0.03353502,0.00826552,-0.01424862,0.05059876,-0.090794556,0.07046636,-0.0075834882,0.049747672,0.03405193,-0.05333592,-0.009025263,-0.01310682,0.123012364,-0.0028670505,0.028446944,-0.032336924,0.014058823,-0.06902035,1.0227848e-33,0.11888724,0.05231327,0.08414213,0.039744806,-0.029043967,-0.0062255575,-0.042744536,-0.011756232,0.016255772,-0.023537217,-0.04149008,-0.05478491,0.037304085,-0.07650548,0.045490455,0.0067903087,-0.026090752,-0.08376091,0.088349804,-0.05271049,-0.028189281,0.07523466,0.010359093,0.0025303408,0.019834742,0.019768331,-0.035529524,-0.029897664,-0.003940278,0.053564716,0.027935017,-0.07149453,-0.08932448,-0.04124758,0.014665366,-0.009730196,-0.05282774,-0.07256154,-0.086151,0.0104548,-0.03630555,-0.03499438,-0.04605475,-0.025167005,0.007345575,-0.0046188706,-0.0705469,0.13487831,0.021404026,0.032133844,-0.021439275,-0.042664535,0.08313771,0.0874908,-0.12516116,0.031851508,0.010408612,0.0071067577,-0.01140597,0.05722607,0.0049989494,0.07245389,0.029005244,0.061451744,-0.062168397,-0.047691617,-0.103571504,-0.012196869,0.003941429,0.06696137,0.04991491,0.040449206,0.08985155,-0.014617583,-0.022741737,-0.027531212,0.0028087895,-0.08984631,0.0063214884,0.04218908,-0.041889526,-0.03180287,0.030235847,-0.013673276,-0.050524823,0.06635627,-0.051491905,-0.011540025,0.012335423,0.0024203556,0.02272008,0.011846719,-0.048549753,-0.03782906,-0.05090042,-1.4714412e-33,0.017867183,-0.0861928,0.01870978,0.053314943,-0.017778957,-0.02612082,-0.011679334,-0.038854294,-0.031592764,0.0066220416,0.046887383,-0.06615822,-0.0027983186,-0.062686615,0.06471154,0.083687685,-0.013556612,0.078427225,0.0864797,0.004723241,-0.04637776,-0.0373662,0.019821657,0.038266197,0.019405348,0.0044046603,0.038564004,-0.08058747,0.030115418,0.055981632,0.0038646506,0.03323947,-0.06652168,-0.12088548,-0.04585091,0.007440447,0.010698602,-0.045318842,0.027612628,-0.014457077,-0.04787135,-0.0020218277,0.052208714,0.1124886,0.109140344,0.055492945,0.007701094,0.080174856,0.07313065,0.059362557,-0.012442154,-0.014137974,-0.0053840657,0.12917599,0.023561677,0.026934061,0.025206368,0.0671916,-0.016805213,0.047706265,-0.023993308,-0.055747483,-0.01819423,-0.00019868115,0.038063843,0.14088611,0.0449697,0.060207818,0.04847218,-0.07000745,0.052066237,-0.04979406,0.0071062096,0.015365151,0.07943073,-0.013346966,-0.013998155,0.1473057,-0.05887705,0.04928022,-0.025016824,0.010863267,0.025841286,-0.048156094,0.043767396,-0.12181364,-0.01701502,0.080871776,0.014884782,0.012175695,-0.07830988,0.0037697013,-0.06884574,-0.07736049,-0.022306021,-1.9489423e-08,-0.0331745,-0.08365946,-0.0072252075,-0.06204272,0.058997568,0.06750513,-0.007000923,-0.03400334,-0.03009042,0.014272798,0.02862188,0.09608977,-0.012869221,-0.034464475,-9.9863464e-05,0.03140988,-0.010801023,-0.0058624707,0.009650841,-0.01713732,-0.0124828,-0.030401202,-0.04116342,0.08526584,-0.047080293,-0.026647095,-0.033105083,-0.045292173,0.026255006,-0.017685594,0.03044616,0.030908285,-0.013713474,-0.06835841,-0.10293436,-0.0028803197,0.018910075,-0.030333793,-0.0035769283,0.047477916,-0.11109211,0.01298881,0.019496761,-0.0048241923,0.039980706,-0.047494937,-0.0054443846,0.054871563,-0.039911143,-0.029603219,-0.026239714,-0.02030655,0.0022487883,-0.0019165179,-0.06958734,0.047094826,0.06418447,-0.05964354,0.008878651,-0.03884944,-0.037133276,-0.0401658,0.05160534,0.01668734 +1.7.1.4,"An iron-sulfur flavoprotein (FAD) containing siroheme. The enzymes from the fungi Neurospora crassa [1], Emericella nidulans [2] and Candida nitratophila [4] can use either NADPH or NADH as electron donor. cf. EC 1.7.1.15, nitrite reductase (NADH).",384,0.99999994,-0.050051324,-0.02910529,-0.106224395,-0.021217206,0.06865947,0.03956759,-0.03594138,0.022332031,0.016316403,-0.0319174,-0.00046034524,-0.022537474,-0.09350468,0.04180431,-0.09445123,0.044147804,-0.02061917,0.00017484161,-0.011807698,-0.035930935,0.03885003,0.019894077,0.056946166,-0.100624,0.06455359,0.027598921,0.0065574427,-0.0729928,-0.01971389,-0.07671326,0.019207634,-0.026724841,0.007147569,-0.060350668,-0.031531762,0.075162835,0.017846106,0.053925253,0.0021600404,-0.0093874065,0.004268614,-0.024093209,0.005564638,-0.015083855,-0.03115152,-0.0073289215,0.016978495,0.06573558,0.063570455,0.020466004,-0.010329277,-0.05465768,-0.0025428429,0.07289555,0.033455353,0.04109071,0.046605814,-0.11542021,-0.004426814,-0.0041862153,0.025625007,-0.059051976,0.026419923,-0.022098713,0.015416171,-0.063325845,-0.014682973,-0.06929948,-0.0038980152,-0.05615769,-0.0060767797,-0.035173606,-0.042019792,-0.0058509833,-0.007486116,0.12592423,-0.004319582,-0.070873424,0.08190099,0.012501757,0.011819786,0.045607183,0.074113466,0.09371014,0.11735239,0.009255249,-0.050670132,0.04034225,-0.07623997,0.0034023563,-0.04551409,-0.009967253,0.036099233,0.009039406,-0.13926692,0.074376844,-0.00045202227,0.04500441,-0.033137437,-0.009702547,-0.019998897,0.07121097,-0.0120552685,-0.07089582,-0.1303596,5.601837e-05,-0.029485095,0.108333394,0.034335684,0.022484804,-0.0153932,-0.023619743,-0.010392065,-0.05934039,-0.027234707,0.040732473,-0.014437018,-0.017090186,-0.09246865,-0.026291287,-0.02127133,0.09144976,-0.013682216,0.04586779,0.051982682,0.009999409,-0.12000939,3.3730766e-33,0.08505999,0.07914063,-0.055096563,-0.024290165,0.0005354549,0.006200672,-0.05945675,0.02486816,0.022418443,-0.08082248,-0.036026727,-0.037174687,-0.0042901705,-0.07406745,-0.0009238705,0.04488202,0.015239419,-0.072336584,0.06873339,-0.053408924,0.049599633,0.092325225,-0.031513624,0.03567931,0.053903624,-0.010365863,-0.033080656,0.06817694,0.030594574,-0.012207697,0.03755207,-0.07651641,-0.0669815,0.019793296,0.029572252,0.007771506,-0.029090803,-0.07151071,-0.07314555,0.03974686,-0.026216388,0.04813445,0.0091279885,-0.036246475,0.045511305,-0.08683652,-0.0373772,0.02460068,0.032122158,0.06417107,-0.01836926,-0.02942135,0.12017371,0.014511382,-0.066126466,-0.00542893,-0.025075864,0.05301632,0.043394346,0.027373342,-0.0052949586,0.025458116,0.0040362766,0.08891962,-0.04214604,0.013508637,-0.016521204,-0.048575908,0.002216138,0.11473953,-0.025047954,0.061059214,0.021174097,0.012251719,0.014543654,-0.094330065,-0.0027939074,-0.074353874,0.045176134,0.027117131,0.059016064,-0.064526595,-0.031185735,-0.040658202,-0.024167474,-0.006201534,-0.05776342,-0.06316158,0.039777506,-0.07255225,0.014974232,-0.07015857,-0.055569515,-0.018844303,-0.0013483256,-3.3601917e-33,0.097493455,-0.07805951,0.07919136,-0.034460217,-0.021018948,0.13422635,0.031741116,-0.020825129,-0.025739973,-0.031431004,0.030583404,-0.04924251,0.036651403,-0.042757895,0.03565872,-0.017014619,-0.022787543,0.03573544,0.080773704,-0.0062820087,-0.07017083,0.12342917,0.0072514424,0.010231095,0.09038721,-0.021327503,-0.015386485,-0.011809069,0.057263114,0.01480488,-0.03436589,0.040723145,-0.081141874,-0.05420851,-0.037281487,0.03521975,0.010650161,-0.0001585233,0.023958,0.057795893,0.007830504,0.007732655,0.030347312,0.08665944,0.035033822,0.032920584,-0.15356629,0.103922546,0.06834802,-0.054556955,0.045914907,0.0021507859,-0.023847211,0.015518515,0.09703244,0.011176345,0.06962052,0.04106056,0.06850173,-0.011983251,-0.069134,-0.078905374,0.011586864,0.0005008506,0.029644739,0.08185605,-0.028703544,0.07970408,-0.009443684,0.057028033,0.06545449,0.025347276,0.03316918,0.06486439,0.010976324,-0.058533505,-0.013557481,0.039576404,-0.022133296,0.012249646,0.058013245,0.0031257414,0.0016780703,0.003000237,0.06574233,-0.0633527,0.037639268,0.06527703,-0.06241,0.010395164,-0.03423387,0.08661389,0.0032632994,0.016712958,0.025852952,-3.908709e-08,0.06863294,0.0060118604,0.032685097,-0.0804984,0.04681984,-0.0102761965,-0.0054700715,-0.08316543,0.016812587,0.023483174,-0.022561584,0.12847897,0.016894585,0.014023718,0.018320385,-0.0064621605,0.022495588,0.013619755,-0.0036784576,0.019336093,-0.048749954,0.042520113,-0.11721339,0.05131946,-0.028503247,-0.031805597,0.07372377,-0.0573114,0.030405637,-0.03380527,-0.04952152,0.03565933,0.056424025,-0.057468776,-0.077730596,0.03927273,-0.018239705,-0.057469245,-0.03735509,0.0056918976,-0.030459188,-0.020106796,-0.020648822,-0.021504141,-0.040036805,-0.04283597,-0.003435264,-0.018807255,-0.030990485,0.000226838,0.034234654,-0.07176672,0.037341755,-0.094061844,-0.10803349,0.037357282,0.007047202,-0.0880611,0.04413299,-0.078249685,0.048663348,-0.030702857,0.099945426,-0.016150799 +1.7.1.5,A metalloprotein.,384,0.9999999,-0.04937257,-0.014977882,0.0007191776,0.10740987,-0.030543778,0.0013909625,0.17494436,0.06890332,0.017018707,-0.021298703,0.01120824,-0.070450395,0.017127732,0.018356713,-0.024764296,0.002881452,-0.019848805,0.047574665,-0.057096943,0.0036901622,-0.022636302,0.039455645,-0.014499267,-0.009465489,-0.081853725,0.10234323,-0.021852747,-0.042476103,-0.039705925,-0.04492146,-0.029629335,-0.02217242,0.00980554,-0.002942266,0.059381347,0.03457918,-0.039465234,0.050326977,-0.045976456,-0.0027506799,0.043010402,-0.0013307524,0.02393769,-0.0052541024,-0.037324443,-0.019994391,0.047602974,0.02943217,0.033035323,0.14564078,-0.07320614,-0.121366285,-0.0154879745,0.087673694,-0.024330502,-0.01239874,-0.063918345,-0.0217041,-0.011435829,-0.0036438534,0.03741416,-0.02179381,-0.013877686,0.054301523,0.11266387,-0.06302253,0.047087148,-0.022601174,0.0063067744,0.05934965,0.079587825,-0.017558279,-0.004447963,0.05637311,0.011175349,-0.0068997955,0.09208549,-0.12437636,0.1242092,-0.0020081385,0.024085287,0.10564609,0.007841462,6.0211205e-05,0.0395011,0.07290301,0.059089847,0.010335949,-0.14143415,0.003944407,0.0011544281,-0.026774323,-0.042705394,-0.049620934,-0.063973725,0.0071576964,-0.0034605192,-0.022399759,-0.019108953,0.0967321,0.009333152,0.035292752,0.033531323,-0.042749688,-0.020071201,-0.079693295,-0.068375774,0.031137072,-0.0049116462,0.0575759,-0.0023427818,-0.021798007,-0.035945676,-0.01447158,0.03442226,0.028990066,0.016732715,-0.017831085,0.01669636,0.041668344,-0.021272307,-0.0035022385,-0.011945489,0.087757155,0.017975498,-0.019413404,-0.12108727,-4.4768886e-33,0.034195807,-0.055094123,0.107960984,0.07963761,-0.0050429995,0.0075123035,-0.013219524,-0.010994778,-0.021847837,-0.016532674,-0.11233131,-0.0112739345,0.0692092,0.005459985,0.03635677,-0.06569177,-0.054127432,0.00869769,0.083667986,-0.08882298,-0.0741971,0.1597543,-0.025040822,0.012602152,-0.039477985,0.011580252,-0.04074191,-0.054519426,0.021813734,0.032730628,0.00016894152,0.008579328,-0.017859325,0.032112725,0.076364174,-0.041585334,0.014523729,-0.070295975,0.0013132449,-0.018060785,-0.050429065,-0.0054053897,-0.07178538,0.013834504,0.07466646,-0.08312504,-0.08476384,0.004027855,-0.07992833,0.010666655,0.08982449,-0.012029981,0.061198615,-0.041346956,-0.12072076,0.057921596,-0.096567184,0.03303645,0.0037727,0.048229955,0.022022124,0.0747172,-0.070600085,0.08692223,0.020393943,-0.033522304,-0.030689502,-0.0730068,0.029043147,0.028180627,-0.0626936,0.004000629,0.112383015,0.029812984,-0.0051436448,0.027510293,-0.031283733,-0.017822709,0.018616728,0.059681572,-0.07447464,-0.0049987077,-0.026209446,-0.007423142,-0.04360696,-0.05348414,-0.016340185,-0.09563171,0.006924938,-0.021097723,0.005790925,0.010912501,-0.05775171,-0.006893723,-0.08141134,5.1395363e-34,0.07427476,-0.10263114,0.050411813,0.046607886,0.010659402,0.010312958,-0.066589095,-0.012629094,-0.030014928,0.07382375,0.08332296,-0.038238093,0.064682215,-0.06843434,0.035553202,0.015033497,-0.04505239,0.077043764,0.05519664,0.03894857,-0.065283336,0.0026750166,0.028668264,0.025624858,-0.061311983,0.012891904,-0.028989263,-0.00977737,0.046084866,0.06865047,-0.025314288,0.020035086,-0.038963698,-0.11869458,-0.040158793,0.031217055,0.008958305,-0.061266266,0.012621597,-0.00019560088,-0.020690465,-0.0009813117,0.044004995,0.15031521,0.0835403,0.028910123,0.017329425,0.04722001,-0.005094698,-0.011446914,-0.027028061,-0.04888099,-0.020703552,-0.059853327,0.014273199,0.016147442,-0.013077043,-0.08059476,-0.0034313642,0.08163848,0.026185429,-0.03719695,0.0058850558,0.060313918,0.0093336655,0.055053513,-0.007453825,0.039233264,-0.017081318,0.0052825985,0.11534878,0.046448197,-0.023447298,-0.03399751,0.0039952355,-0.08649123,-0.025833257,-0.0070870514,-0.022132676,0.02099194,-0.048145134,-0.0025482874,0.0028834401,-0.008208066,0.055867195,-0.09130614,0.026589898,0.083445,-0.05292057,-0.004445941,-0.04159861,-0.06669375,-0.086486764,0.08243836,0.018194381,-1.8209311e-08,0.0056077563,-0.009013927,-0.002213321,-0.13953291,-0.0020250352,0.07398772,0.0151316915,-0.08978276,-0.0038295903,0.021801682,0.044118345,0.04176032,-0.021246437,-0.013963772,0.037709575,0.03407311,-0.028460499,-0.07235807,-0.018419381,-0.008722568,-0.029752387,-0.009595356,0.050449353,-0.04647914,-0.04866343,-0.022623235,0.027433913,0.048218664,-0.113918744,0.029980574,-0.03434195,0.06461847,-0.086500205,0.015655287,-0.03848525,-0.007600964,0.0004595771,-0.006882468,-2.3903754e-05,0.023826756,-0.047747962,0.04019872,-0.018302625,0.025580473,0.02679533,-0.026461318,-0.023250867,0.014860647,0.005745053,-0.04837473,0.003355074,0.0281158,-0.03749475,-0.0064793006,-0.03325572,0.028939223,0.024066493,-0.04251014,-0.078180484,0.003114249,-0.009788011,-0.037212085,0.097513914,0.05343963 +1.7.1.6,"The reaction occurs in the reverse direction to that shown above. Other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B can also be reduced [2].",384,1.0,-0.0071817287,0.06626007,-0.054917928,0.0341511,0.0667974,0.02486594,0.1156249,-0.0030880854,0.055601407,0.059830226,-0.013618879,0.071785994,0.04241548,-0.013016787,-0.052398063,0.1182716,-0.05159346,-0.0025558115,-0.09864511,0.009462928,0.010292968,-0.08300604,0.018901827,0.033710912,-0.058370415,0.004654749,0.04327795,0.04539691,-0.03449584,-0.043339897,-0.0026132897,0.057689786,0.071351945,-0.09887824,-0.017848348,-0.07345064,-0.03748346,-0.05272073,-0.016897324,0.021063786,0.054736942,0.039743926,0.0001667094,-0.018698469,-0.030304797,0.078165725,0.043944243,0.014257384,0.021755602,-0.019880105,-0.019214028,0.010989684,-0.10493496,0.052837726,0.008016985,0.055115473,-0.1281072,0.020529758,-0.008960861,0.029461099,0.031554002,-0.031173998,-0.039462626,0.0126247,0.026932932,0.046260674,0.03525407,-0.039005607,0.014929174,-0.023202263,0.043201793,-0.019162636,0.0007065359,-0.056296986,0.052310817,0.097360544,0.09003204,0.029028736,-0.0037150022,-0.011420444,0.0059264116,-0.011701647,0.034239274,0.05257086,-0.0085363025,0.03376042,-0.044868488,-0.033145335,0.050436344,0.07246171,0.039990302,0.07964681,0.055645738,-0.07319577,-0.031402197,-0.053660166,0.039220124,-0.005751726,0.06476061,0.028165782,0.02357524,-0.017578103,-0.07785655,-0.08039493,-0.084771916,0.03270612,0.04564746,0.044581268,-0.056991387,0.042648293,0.00013963818,-0.042858522,0.061663635,-0.013866735,-0.041282855,0.10265495,0.11939486,-0.023290318,-0.15610091,-0.00028022882,0.0134527385,-0.042490963,-0.0311137,-0.0062011136,-0.04510586,0.020902814,-0.046820845,1.5211292e-33,-0.025869692,0.11748539,-0.006912204,-0.11815299,0.07509729,0.049055632,-0.06758436,-0.02138624,-0.011555781,-0.04434391,-0.01885069,-0.010858944,0.01084222,0.01731158,-0.072583705,-0.074926,0.08137741,0.010032564,-0.07990927,-0.015132608,-0.01412579,0.115100406,-0.089881085,-0.04224843,-0.054881424,0.08573363,-0.018518476,-0.027760306,-0.011632774,-0.049919553,0.0463489,0.038988683,-0.116704755,0.002606627,-0.050852098,0.022514159,-0.088977195,0.04459802,-0.01746519,0.048632905,-0.02304776,0.049697492,-0.09966882,0.09835219,0.050639793,-0.088197164,-0.031027531,-0.038003024,0.11017447,-0.020982714,-0.035834175,-0.030020554,0.023548776,-0.005842474,-0.015198509,0.012668348,0.036929306,-0.002695014,-0.03101363,0.013678126,0.009498301,-0.01926479,-0.023299962,0.024983443,-0.04436523,0.0125145875,-0.042735305,-0.038808566,-0.022729555,-0.056917123,0.019786214,0.03812298,0.11340381,-0.013947486,-0.017954709,-0.009871933,0.031567376,-0.046263468,0.06996887,-0.043251783,-0.08252917,0.017534327,0.03395098,0.011466661,-0.05875878,-0.043949887,-0.011406775,0.045001205,-0.025422467,0.01172343,0.042909387,-0.08990312,-0.06133505,-0.026869718,0.017662387,-2.1653647e-33,0.022022173,0.009924676,-0.058547735,-0.034904785,-0.047973897,-0.0004677689,0.1248139,-0.0035781153,-0.0007247351,-0.020981468,0.1126552,0.0019389536,-0.003703037,0.059726857,-0.050041277,0.031496014,0.12412379,0.11727937,0.019246964,-0.06857686,-0.12066129,0.05358901,0.073776096,-0.0086854985,-0.020423817,-0.015543522,0.08261836,0.017354196,0.080363184,0.03848251,-0.013501503,-0.031860396,-0.06947791,-0.03645872,-0.009120815,0.047223,-0.014168835,-0.016083704,-0.059804134,0.048407927,0.05849396,-0.1358934,0.0025536688,0.026201421,0.0058531077,0.040546503,-0.11816656,0.06404465,0.012399417,-0.038723134,0.025119206,0.011659883,-0.046365704,0.07797786,0.043446954,-0.009840839,0.06987861,-0.011521439,-0.037570328,0.08221213,-0.023228312,0.011633773,0.048586022,-0.060533624,0.036245394,0.09064912,0.08966695,0.06527245,0.029907893,-0.10282305,0.12918915,0.0918937,-0.010556482,-0.000117678406,0.060393043,-0.057992887,-0.05117139,-0.011948791,-0.038876712,-0.053887624,0.007899878,-0.02477452,0.040039018,-0.038982946,-0.04637376,-0.02828016,-0.045804843,0.04450258,-0.0016981137,-0.009859172,0.044711914,-0.027656645,0.07221299,0.062091324,-0.021454247,-3.1450067e-08,0.014457382,-0.072434,0.057070896,0.007369649,0.00792957,0.029050969,-0.017158473,0.051874164,-0.0066115255,-0.05976499,-0.035729185,0.04838818,0.029748363,0.03246365,0.022507543,0.0038469103,-0.015145291,-0.0752474,0.0042377985,-0.027167996,-0.10534758,-0.011974437,-0.06669054,-0.040589646,-0.025574489,-0.026687084,0.005681114,0.021660035,-0.02465405,-0.048425596,0.03671074,0.025306353,0.023695724,-0.036443107,0.0003427222,0.01195167,0.023282338,0.004597404,-0.048631664,-0.0027443417,-0.07677737,0.0006973021,-0.023355873,0.020213831,0.025282456,-0.0074501242,-0.042675175,-0.051373,0.0010249409,-0.006081584,0.02609889,0.0078536775,-0.0037782043,0.011164399,-0.074097425,-0.082770154,0.03518286,0.04418398,0.002011091,0.041174594,0.008015205,-0.056928765,0.03451577,-0.013799865 +1.7.1.10,Also acts on some hydroxamates.,384,1.0,-0.02779873,-0.09213289,0.059879914,0.04794775,0.0036526113,-0.024978386,0.046949096,0.0037745554,-0.018722553,-0.03774822,0.03203857,-0.004204353,-0.028969675,0.096095264,-0.03627324,0.07291547,0.008394826,0.024531642,-0.03138627,0.03799624,0.024229972,-0.03125775,0.023102256,-0.00034506808,-0.10965642,0.072686136,0.0030538766,0.034429792,0.045466725,-0.11205515,0.0058386414,0.09197767,-0.026374359,-0.07355328,-0.030936463,0.11179393,0.012648014,-0.0005706538,-0.011785004,0.022798775,0.12060764,-0.110571474,0.06733223,-0.06880295,-0.015045048,-0.0519148,0.015989311,-0.043423817,0.049052503,0.05736892,-0.017360762,-0.111820355,0.02278684,0.070794106,-0.045659438,-0.009933874,-0.082084894,-0.034237497,0.044147406,-0.024332425,-0.017302183,0.071497135,-0.013925983,0.069186315,0.012385873,-0.0058430787,-0.010754953,-0.027785785,-0.026605688,-0.020608837,0.016925618,-0.03509042,0.04503313,-0.006332504,-0.06411316,0.007610585,0.009329791,-0.073707715,0.024844559,-0.0008986227,-0.089586176,-0.02250398,0.046941284,0.030517535,0.058306426,0.017570203,0.044009514,-0.085126944,-0.056529723,0.04597079,-0.062252425,0.032373816,0.03666789,0.06480249,0.029304616,0.025936017,-0.004241489,0.008392709,-0.03675124,0.019047676,-0.06206065,0.008005671,-0.02928767,0.031250246,0.025535949,-0.01820064,-0.031905517,0.033592198,0.0021382943,-0.010188147,-0.090427026,-0.0113432575,0.023496611,0.0850806,-0.026259666,0.056691866,0.0004719021,-0.022834543,-0.043377567,-0.069021516,0.034859035,-0.082211725,-0.012806693,-0.0017228422,0.031393897,-0.007244336,-0.033267975,-2.6242577e-33,0.044586774,-0.07583739,0.01629698,-0.019638356,0.0106192455,0.00978431,-0.053131368,-0.026147608,0.01079583,-0.009984216,-0.077240214,0.038288742,-0.0033224835,0.07060944,-0.04943609,-0.08399377,0.0046357927,-0.005103657,-0.033273157,-0.047255244,0.014699841,0.08747629,-0.099093646,-0.018263299,-0.0764009,0.026429174,-0.037481662,-0.057923242,0.020850115,0.018208394,0.037960283,-0.015644131,-0.044993956,0.12560335,-0.038058333,0.15861176,-0.0591506,-0.075621866,-0.060357925,0.038621522,-0.002048149,0.000104021856,-0.03285011,-0.08375207,0.005574493,-0.04088005,-0.04525933,0.005665913,0.02036644,0.014347494,0.078127734,0.037311293,0.038765363,-0.016819375,-0.007060395,0.038835213,0.00069475325,-0.005472777,-0.031001695,0.105631575,-0.0406832,0.04242033,-0.061621908,-0.003959703,-0.013945128,0.018611103,0.0017357492,-0.013277287,-0.032557327,-0.00076781143,-0.11286141,0.044836793,0.11030622,-0.013194508,-0.024086105,-0.06463805,-0.021106515,-0.042788457,-0.00470565,0.082460135,0.056453615,-0.044626754,0.06823687,0.02854083,-0.05589158,0.02343136,0.009448166,-0.039123077,-0.005732468,0.05841062,0.07620566,-0.0837759,-0.027700087,-0.05542664,-0.001738249,1.2420677e-34,0.022405853,-0.05905153,-0.009775387,0.04794049,0.04762352,0.044955954,0.068614945,0.027219936,0.0006724345,0.008395524,0.03994634,0.038387988,-0.034387663,-0.046317153,0.013588498,0.015390991,0.04991555,0.0015973195,-0.0004915133,-0.10033077,-0.0029186644,0.06887223,0.050282765,0.057098996,0.017796578,0.067195915,0.008449027,-0.00077035796,-0.04038233,0.04798204,-0.06454951,0.02224489,-0.09662789,-0.056443654,0.008190757,0.025176348,-0.1273946,0.037360042,-0.007427656,-0.103450835,0.0139489435,-0.09671498,0.060107034,0.1010141,0.031915653,0.105461,0.021410333,-0.025554564,-0.06579506,0.066183716,-0.037361722,0.07103956,-0.070375614,0.036883384,0.035141267,0.003016222,0.040289406,-0.088621885,-0.021298908,-0.03589443,0.00093397836,0.059365384,-0.022134999,0.002748043,0.0009418386,0.044304043,-0.044819042,0.024811352,0.083297305,0.036796562,0.120815255,0.00065584213,0.0076179556,-0.038531527,-0.051262088,-0.059972405,-0.0683551,-0.11619573,-0.019212252,-0.046698045,-0.016337503,0.011670685,0.040180378,-0.009847482,-0.0024476608,-0.052817747,-0.017442925,0.024650887,-0.00087515096,0.032680206,0.012329491,-0.02908032,-0.043830816,0.029095719,0.04081365,-1.7315298e-08,-0.014434162,-0.02610795,0.028657502,-0.03880721,-0.0033384454,0.05772009,0.037606336,0.07836553,0.040450726,-0.038674284,0.028371125,0.056007784,0.093423665,0.033728026,0.08160838,-0.04145853,-0.0033496586,-0.044026572,-0.09625099,-0.058093753,-0.17090398,-0.043249555,0.015575499,0.12637451,-0.075665385,-0.009232772,0.03503196,0.020266455,0.07873389,0.0030346042,0.024139598,0.0057245037,-0.028388435,0.00062863255,0.00807118,0.10119671,0.046341617,-0.019815484,-0.010304055,-0.0027868194,-0.017146682,-0.037493784,-0.0013224069,0.023904832,0.040452108,0.029766267,-0.061391436,-0.028350797,0.043603476,-0.0031392006,0.084163845,-0.008043587,-0.017468398,0.029082166,-0.0328996,0.05076577,-0.02584142,-0.1178221,0.03506416,-0.013388421,-0.04604114,-0.017160865,0.18639931,0.037615605 +1.7.1.12,"Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl.",384,1.0,0.05597604,-0.09703718,-0.029396128,0.021191707,0.06967919,-0.0066697737,-0.013792083,0.026504973,0.06387434,-0.06935077,0.06190861,0.051939327,-0.014215052,0.06821098,-0.0141009735,0.06264497,0.010062553,-0.023994567,-0.030479481,-0.022540186,-0.018034874,-0.02471254,0.03453218,-0.025584247,-0.015517217,0.04466293,0.04777344,0.011891005,0.024617953,-0.121298224,0.04098629,0.06573155,-0.009001287,-0.023679372,0.016798405,0.029212892,-0.043671414,0.054376993,0.07903036,0.00454418,0.03974852,-0.032875393,-0.0014310183,0.019252807,0.038612746,0.008635873,0.013304084,0.023355601,0.09418184,0.044632442,-0.05465638,-0.05749637,-0.0028010118,0.04637863,-0.02650392,0.03521241,-0.20429824,-0.032162163,0.036592916,0.052771922,-0.048260882,0.003173096,0.0057492624,0.021996848,0.037598584,0.04302633,0.07819489,-0.09044181,-0.0028588662,0.032785706,0.03261173,0.025876353,0.009646995,-0.0022755875,-0.0403496,-0.07519965,-0.026076911,-0.016604653,0.008283366,0.000101906364,-0.0319845,0.006815468,0.0029644186,0.07762101,0.03939847,0.008741912,0.00794254,-0.110234134,-0.025336461,-0.0011950545,0.01750259,0.0019050662,0.004416687,0.03583272,-0.05415893,0.0074253483,0.0035940341,0.045002934,-0.0335336,0.03155558,-0.076021634,0.02559886,-0.07411661,-0.07268575,-0.012730799,0.015984809,0.09271372,0.03224918,-0.05769879,0.0782941,-0.0028346882,-0.015134247,-0.015111888,0.018433945,-0.111931615,0.07191359,0.00074046664,0.008941892,-0.037623372,-0.051191602,0.0018205962,-0.00532317,-0.029799808,-0.006101515,-0.028916704,0.14288586,0.013794276,-2.713222e-34,0.059443496,0.018950682,0.0068051526,-0.0320578,0.044216163,-0.008549067,-0.10448009,0.011683373,0.014631399,-0.06338331,-0.04447297,-0.06852564,0.020671057,0.047039565,-0.014641314,-0.06746296,-0.0367494,0.008747687,0.043596487,-0.037684027,0.0070185885,0.040375944,-0.09196543,0.045071304,-0.13026994,0.0070326086,0.025134781,0.016176548,0.04880745,0.0060553337,-0.02377841,-0.018486857,-0.046039123,-0.006449295,0.0021058149,0.08831174,-0.03500394,0.005237513,0.027195355,0.00846714,-0.05595626,0.065617815,-0.06633103,-0.076526366,0.014888483,-0.06534994,-0.08778814,0.08982472,-0.01980052,0.075264625,0.06665794,-0.046362363,0.11737091,0.017273149,-0.030642973,0.014133893,-0.018881928,-0.024028238,-0.015370921,0.032704644,-0.008748739,-0.040808868,-0.010603406,0.026961155,0.042886753,0.04442996,-0.027366836,-0.024631849,0.0061090267,-0.0353996,-0.031656474,0.021656496,0.118983746,0.06930274,0.028999416,-0.07835662,-0.013846212,0.0014357797,0.08108371,-0.0036351897,-0.0036456264,-0.026051711,0.05733107,0.00916815,-0.0036000952,-0.016331276,0.012291217,-0.08152834,-0.014784293,0.014110256,0.03167264,-0.08250491,-0.056931335,0.023605755,-0.011327925,-6.3666165e-34,0.054278605,-0.05907729,-0.0013080558,0.07043464,-0.03353668,0.057898484,0.022584772,0.05344902,0.008016254,-0.0003327673,0.10932672,-0.06055645,-0.06510592,-0.024393544,0.02691051,0.039107647,0.058945224,0.06120818,-0.019628722,-0.0046927924,-0.0061143073,0.06804972,0.02272724,0.117538385,0.084540874,0.020473696,0.055787053,0.0045690304,-0.0030476619,0.07112021,-0.05740278,-0.00840063,-0.063726656,-0.071556136,0.00026870667,0.12136934,-0.021985533,0.0029868765,-0.05992483,-0.02929446,-0.0073271166,-0.0136756385,0.039624047,0.07538885,0.0098534785,0.078156814,-0.046278358,-0.005413307,-0.10992374,0.041208018,0.0265945,-0.006251849,-0.05782857,0.05391124,0.060447328,0.06729856,-0.005101907,-0.053179987,-0.055751346,0.0035376386,-0.038115185,-0.019703023,-0.01945458,-0.040089995,0.07254672,-0.0027147287,-0.07496955,0.0398594,0.04936979,0.0010223278,0.02375829,-0.028839791,0.027285075,0.09247817,-0.05145247,-0.09917435,0.02272022,-0.09901829,-0.07312124,-0.048676744,-0.042810418,-0.007177067,0.019282842,-0.09961103,-0.101074904,0.01747057,-0.034225676,0.0306219,-0.047692448,0.105589435,0.035988215,0.0066610076,-0.06966839,0.035640426,0.017386958,-2.453544e-08,0.08243915,-0.05754802,0.092173874,-0.041666288,0.0047728927,0.042316817,0.030722704,0.07610288,0.017099267,-0.12270995,0.007202944,0.12419956,0.024509367,0.041217532,-0.013323065,-0.01299016,-0.01826478,-0.010861824,-0.08782115,-0.024664039,-0.14772312,-0.0037697644,0.01706931,-0.007095511,-0.006428709,-0.047675524,0.011683088,0.06461577,0.025363049,-0.106101155,0.047935072,0.024750022,-0.01740964,-0.12048619,-0.061221242,0.048591107,0.058714908,-0.027042769,0.040686633,0.055252813,-0.071669154,-0.042261798,-0.06615026,0.01098689,0.012614863,-0.06561821,-0.014897608,0.009531149,-0.005209594,0.0129312035,0.025409812,-0.013493688,-0.014026548,-0.061350774,-0.058399867,0.016562713,-0.033438914,-0.061227255,0.09612103,-0.052861303,-0.015121208,-0.015867826,0.095905505,0.06649621 +1.7.2.1,"The reaction is catalysed by two types of enzymes, found in the perimplasm of denitrifying bacteria. One type comprises proteins containing multiple copper centres, the other a heme protein, cytochrome cd1. Acceptors include c-type cytochromes such as cytochrome c-550 or cytochrome c-551 from Paracoccus denitrificans or Pseudomonas aeruginosa, and small blue copper proteins such as azurin and pseudoazurin. Cytochrome cd1 also has oxidase and hydroxylamine reductase activities. May also catalyse the reaction of hydroxylamine reductase (EC 1.7.99.1) since this is a well-known activity of cytochrome cd1.",384,1.0,-0.13179919,-0.016748236,-0.07062886,-0.017901117,0.0018379207,0.043548897,-0.006764495,0.05827228,-0.032019634,-0.010153725,0.016392713,-0.042489987,0.021714052,0.018096833,-0.069643565,0.052982446,-0.07069903,-0.012545271,0.033932235,-0.041987002,0.023801442,-0.00010271967,-0.026712894,-0.010187666,-0.017156957,0.029254207,0.022140551,-0.025356555,-0.09625525,-0.06977467,0.014451013,-0.035556138,0.018530443,0.013129678,0.10569792,0.04072159,-0.08706295,-0.05331475,0.029041281,-0.03147116,0.0688774,0.049966313,0.012627155,-0.032119162,-0.014778596,-0.09139042,0.039785307,0.08122563,0.020331563,-0.06635483,0.035772912,0.018409608,-0.018980155,0.043526705,0.07318602,-0.009451438,-0.0772079,-0.0603417,0.045463584,-0.014396987,0.004051299,0.024169087,-0.007600504,-0.0069178194,0.016676683,-0.0748912,-0.014330433,-0.026741026,0.0422653,-0.047243085,-0.027237445,-0.079168975,-0.020434896,-0.011381654,-0.038943507,0.03363418,0.07534148,-0.045946725,-0.018818237,-0.056655873,-0.014408829,0.026918625,0.05075961,0.10039102,0.078900345,0.03150686,0.014386066,0.022970144,-0.004619295,-0.034027487,0.0020715194,0.031246228,-0.013327369,-0.025630902,-0.087521456,0.01494317,0.04693678,0.04541858,0.06421671,-0.020409714,0.008867774,0.103961565,0.051659603,-0.109665,-0.032104187,-0.021521365,0.00029700805,0.17988189,0.08595549,-0.039070293,-0.03643377,-0.02635042,-0.0181412,0.0229793,0.008564956,0.06926797,0.09503831,-0.027736837,-0.11252016,-0.07169474,0.02199881,-0.113927685,0.0088858735,-0.048297945,-0.013250035,-0.0074691884,-0.1537804,6.8715484e-33,0.032809798,0.018915234,-0.025514727,-0.021461729,0.009768313,0.024968095,-0.043758743,0.026989928,0.04974387,-0.016303133,-0.030967833,-0.019319935,0.028073102,0.025532829,-0.10170601,-0.052955125,-0.009344309,-0.0022015404,0.010854099,-0.018737048,0.03496572,0.09144962,-0.029341044,-0.051774457,0.040733557,0.016205795,-0.026828863,-0.037058234,0.030141262,-0.007960752,-0.0016426916,-0.03727812,-0.08867314,-0.018419234,0.057903375,-0.004291923,-0.018384023,0.04509267,0.010794992,0.12470175,-0.06924591,0.03593932,-0.042969376,-0.060633425,0.079822555,-0.045519333,-0.10521335,0.116984285,-0.006879998,0.0708976,0.073733486,-0.0041842633,0.13836107,-0.028861133,-0.0041153743,0.024791645,-0.014675208,0.00086965685,0.07770625,0.043878645,0.07217508,0.059321843,-0.09539076,-0.008725479,0.02735759,-0.006222466,-0.01061807,-0.008763331,-0.00428923,0.06576846,-0.103304245,0.056754306,0.07493435,-0.0049884166,0.07426433,-0.039209906,-0.056057986,0.007904096,0.05997765,0.04577461,-0.026995212,0.011574743,0.021872336,-0.01529526,0.014437247,-0.011860336,-0.047797956,-0.009053219,-0.026187979,0.04596871,0.07251138,-0.07087029,-0.08670956,-0.03202842,-0.009938383,-7.253445e-33,0.038677905,-0.058513623,-0.004146269,-0.13030612,-0.019395033,-0.020508813,0.030094422,-0.0018225022,0.04209261,-0.0077011753,0.061332412,0.014331667,-0.012630445,0.009959288,-0.027243616,0.0012735217,-0.040758606,0.095525414,-0.096172065,0.04083586,-0.028914629,0.030802384,-0.018041408,-0.006475047,0.017007176,0.051834505,-0.02653147,0.07511078,0.084809475,0.0031896015,-0.062027816,0.06555043,-0.033696186,-0.05627165,-0.035730526,0.056242976,-0.08532871,0.023584034,0.036367822,-0.0025779656,0.06066919,0.01751114,-0.010662246,0.07877512,0.07644777,0.06970426,-0.06960451,0.013532957,-0.03753072,0.0335228,0.04275886,-0.024489813,-0.0023216538,0.006071221,0.034401495,0.00021474177,0.03444866,-0.007042364,-0.0088049965,0.015409769,-0.056768883,-0.068688266,0.014805011,0.03630311,0.009427909,0.0035557891,0.016286796,0.11090523,-0.01621553,-0.024213525,0.09954472,0.06368927,0.016706321,-0.053358026,-0.01178283,-0.04151734,-0.07358293,-0.018274134,0.030054579,-0.0067876484,0.04119078,0.01817878,0.019130638,-0.08806688,0.040609505,0.037854455,0.010227172,0.04819791,-0.057651386,-0.04423687,-0.043974347,-0.03324034,0.042571876,0.09069769,0.007708962,-4.3481286e-08,-0.0068123615,-0.04687332,0.05306006,-0.036856733,0.04414771,0.072846994,-0.050705444,0.018682327,0.04255742,-0.06610985,0.022576768,0.11988889,0.01006293,-0.031360254,-0.029733444,0.066447936,-0.010161552,-0.08890189,-0.007861806,-0.030680608,-0.052943908,-0.011877497,-0.13149232,0.08573913,-0.014848657,-0.04817104,0.01740241,0.020048028,-0.06216093,-0.057532933,-0.010716687,0.04174436,-0.01790151,0.008764786,0.020835537,-0.0741956,0.029242376,-0.017037649,0.021268055,-0.073153876,0.00019608646,-0.061820377,-0.06550071,-0.019281918,0.01859461,-0.027778141,-0.020686947,0.019354045,-0.023052834,-0.014521596,-0.00083272014,-0.062956415,-0.00017893204,-0.09596181,-0.08721371,0.038681366,0.04020712,-0.019216761,-0.039754022,-0.00018480196,-0.009880134,-0.007351899,0.18771668,0.055761933 +1.7.2.2,"Found as a multiheme cytochrome in many bacteria. The enzyme from Escherichia coli contains five hemes c and requires Ca2+. It also reduces nitric oxide and hydroxylamine to ammonia, and sulfite to sulfide.",384,0.99999994,-0.06644461,-0.002898328,-0.044161856,-0.011687198,0.0076265736,0.05683339,-0.046824742,0.09800938,0.047119632,0.013309982,-0.010826214,-0.07976688,-0.03478868,0.087625995,-0.054831117,0.0030349116,-0.03062033,0.022461182,-0.010089896,-0.088931695,0.02046361,0.04556516,-0.002933127,0.002114975,-0.04552329,0.020610483,0.0124317715,-0.018796148,-0.032632265,-0.05382265,-0.012853363,0.010579619,0.09615883,-0.06438603,0.090577155,0.02194367,-0.013282582,-0.08871136,0.05279573,-0.057161868,-0.013405913,0.08088243,-0.011466406,0.039504975,0.0065224767,-0.02587223,0.048414376,-0.018546114,0.050569996,-0.080370694,-0.01266092,-0.0042890036,-0.0708963,0.07495836,0.05370202,-0.023835588,-0.06587326,-0.047950923,0.015252412,-0.012801959,0.022367412,0.008246945,0.04085788,-0.037236255,0.029064935,-0.047623478,0.009060125,-0.04486178,0.006861315,-0.047503635,-0.048366442,-0.07116702,-0.00020406874,0.05833588,-0.070272475,0.043847773,0.039491903,-0.09015221,0.05051407,-0.023287542,-0.017325625,-0.022125663,-0.0014607938,0.15316857,0.05451871,-0.015606353,0.0044971053,-0.01358059,-0.020449368,0.008889332,0.028632384,0.025505483,0.022934303,-0.105034664,-0.041139565,-0.02042066,0.014604006,0.07563035,0.041803617,-0.062575236,0.071443744,0.07754384,0.022752702,-0.04851142,-0.043934584,-0.014186133,0.06729204,0.11284841,0.04470071,-0.040809438,0.011968889,0.025429133,-0.017897747,-0.050058916,-0.03290698,0.068660796,0.101212636,-0.03188042,-0.08028854,0.0724146,-0.060897067,-0.09289068,0.017487837,-0.030821092,-0.03813902,0.015252897,-0.1113671,2.7964318e-33,0.03546372,0.042486813,0.049035836,-0.02213017,0.0028461772,0.017617613,-0.07151196,0.005247253,0.00014621032,-0.036952153,-0.05647341,-0.048646603,0.04308249,0.028413104,-0.008817537,0.062256195,-0.07239541,-0.04993297,0.074000046,0.00392164,0.015918722,-0.0050639254,0.018441651,-0.06998307,0.029160192,0.042764414,-0.015314211,-0.0019620075,0.028855568,0.0038996097,0.006280807,-0.0558682,-0.07742692,0.021760572,0.13093072,0.0063848197,-0.020175025,0.040848557,-0.0316543,0.09777298,-0.04603113,0.052296788,0.038991414,-0.032402966,0.09476062,-0.0768441,-0.13562746,0.04756255,0.043777928,0.09797741,0.01762935,-0.019299658,0.07923315,-0.03106122,0.0044518085,0.0060409503,0.019949486,-3.7087448e-05,0.030003589,0.046480343,0.037064787,0.08260199,-0.08398757,0.049792275,0.08175478,0.026565855,-0.03101323,-0.0049731913,-0.03317305,0.10395631,-0.114346825,-0.029952668,0.047910616,-0.016963959,-0.0008427575,-0.04158662,-0.0627924,0.03196801,0.09275061,-0.023804402,0.015229794,-0.05787305,0.022912875,-0.0073812352,-0.016980087,0.0027810817,-0.011544974,-0.014924355,-0.053267132,0.06982773,0.06600814,-0.10613037,-0.05250866,-0.02456727,-0.043480236,-4.182362e-33,0.1049836,-0.05753343,0.011938039,-0.1355734,-0.05180803,0.050940383,-0.018902877,-0.06528668,0.050514314,-0.0067461007,0.12022717,0.038710885,0.04014835,0.0015806095,-0.022385145,0.026902197,0.008029783,0.040961154,-0.01494765,-0.025498448,0.035342027,-0.022023765,0.00082285336,-0.023873921,0.047158018,0.041555468,-0.058229674,-0.022881899,0.0805088,0.022959149,-0.050280582,-0.0023473052,-0.020095,-0.09015064,-0.02599367,-0.0077259517,0.005324732,0.01830506,0.0076856758,0.019087818,-0.029761638,0.015627721,0.07500138,0.10551752,0.010011204,0.09129124,-0.07728029,0.0013468979,-0.018040203,0.032439042,0.035133503,-0.0676202,-0.071179256,0.01178428,0.02467075,-0.016278192,-0.017015096,0.052744534,-0.06604458,0.017743,-0.029235907,-0.038840592,-0.013498511,-0.015077549,0.008522342,0.031442452,-0.04497258,0.04809017,0.008480521,-0.06799945,0.017282385,0.009678593,0.03285321,-0.02999654,-0.06793895,0.0002809866,-0.036428463,-0.018300949,0.08377008,0.05251206,0.009668878,0.026791407,-0.03872792,-0.042100653,0.057848763,-0.042025857,-0.039057072,0.10173259,0.0279972,-0.037061848,-0.019493423,0.028688543,-0.011359968,-0.0015484701,-0.00081117044,-3.571786e-08,-0.009101638,-0.10212293,0.0010858398,-0.040626377,0.011454725,0.05902503,-0.018717157,0.0400848,0.062033556,0.015702486,0.030517623,0.121814795,-0.06430274,-0.018667009,0.04325894,0.007950606,-0.05691953,-0.051741976,0.020348778,-0.010762098,-0.046761844,-0.014437566,-0.05026006,0.0667112,0.04626332,-0.0944075,0.026367545,-0.055882372,-0.05391724,0.003081145,0.0023147734,-0.012593089,-0.012796167,-0.043380868,-0.013540856,-0.042656567,-0.021041965,-0.056236126,-0.04387991,-0.025178242,0.070072785,0.010686916,-0.13606039,-0.0052046943,0.070147075,0.024751144,0.002272265,0.07261507,-0.07542182,-0.04323228,-0.00091765367,-0.054135147,0.0106684305,-0.029279208,-0.1302249,0.0080494145,0.08921676,-0.08040411,0.009440744,-0.07249525,0.06305192,-0.009306951,0.16824618,0.034098275 +1.7.2.3,Contains bis(molybdopterin guanine dinucleotide)molybdenum cofactor. The reductant is a membrane-bound multiheme cytochrome c. Also reduces dimethyl sulfoxide to dimethyl sulfide.,384,1.0,-0.0395868,-0.014186122,-0.137874,-0.026885767,0.0064955656,0.004139269,0.019804187,0.05088266,0.01572592,-0.088638574,0.04971905,-0.033324227,-0.027832812,0.04738074,-0.035706483,0.031993013,-0.020088837,0.047007658,0.019357217,-0.06405594,-0.049427032,0.0024768712,0.06509137,0.012022159,-0.052598767,0.053374648,-0.0059530805,-0.058757164,0.005334678,-0.040958453,-0.026488122,0.047334697,0.10611794,-0.05573955,0.017726734,0.07397812,-0.046390932,0.018317582,0.011865933,0.014111628,-0.00313334,0.104960196,0.048015196,0.030072294,0.0662456,0.014304381,-0.021262309,0.029342921,-0.03052229,-0.012214867,0.041778572,-0.0002474936,-0.09554998,0.09734386,0.045121495,0.042281542,-0.07426457,0.029270612,0.04436858,0.061337356,0.02626969,0.036183767,0.01663346,-0.029889686,0.049882114,-0.0012417758,0.026362993,-0.058981325,0.06665799,-0.024284462,-0.033977006,-0.041164134,0.005608485,0.00016057111,-0.037110083,0.07658507,0.046670236,-0.01839701,0.07756722,-0.041281775,-0.039075382,-0.010625397,0.023207283,0.09103549,0.088679366,0.011448421,-0.00075375376,-0.063248955,-0.051184956,-0.023936817,0.080184996,-0.004691788,-0.043291423,-0.046934906,-0.1421292,-0.06220032,0.0112623535,0.056401946,-0.0513661,0.010346321,0.059312705,0.055105958,-0.042158682,-0.07850224,-0.10505126,-0.008087792,0.049348895,0.022713294,0.056121703,0.015315098,-0.04317955,0.076719284,0.031410873,-0.026819913,-0.024517987,0.019292243,0.036139097,-0.0050154803,0.054169226,0.021568619,-0.03486159,0.01223403,-0.057425793,-0.033774216,-0.015408887,-0.009520511,-0.066930674,9.261607e-33,0.06799111,0.05315987,0.035733324,0.01357424,-0.041143063,0.007531864,-0.08183693,-0.02817892,-0.031711936,-0.010709622,0.006915009,-0.03348894,0.013890282,0.032784306,-0.024298286,0.0008788648,-0.089337416,-0.078363165,0.08472058,-0.08948484,-0.042988382,0.044523515,-0.06224826,-0.043205652,0.10908549,-0.02348399,-0.028602984,0.061370708,0.008090627,0.018646467,-0.012006222,-0.07778282,-0.11917704,0.03771471,0.022816405,-0.0036688964,-0.033166017,-0.07200174,-0.012442721,0.047260378,-0.09338865,0.0053772167,0.029885098,-0.00913467,0.082951546,-0.035526596,-0.10569605,0.082375914,0.095304884,0.027619418,0.038643662,-0.06716361,0.0025586544,-0.018483328,-0.0881961,-0.015855085,-0.016179068,-0.020869043,0.0025780164,0.12782608,0.0063787475,0.034565743,-0.04646157,0.007838058,0.03382724,0.031624075,-0.10701946,-0.056423757,0.01789544,-0.015867256,-0.051207233,-0.016703043,0.10822716,-0.004155094,-0.05328265,-0.044309143,0.07416601,-0.001106746,0.043301187,0.009367304,0.0076248925,-0.052970905,0.04665263,-0.05472049,-0.07269574,-0.023118988,0.020245306,-0.1054328,-0.02626844,0.033091504,-0.041413344,-0.01646629,-0.060736828,0.0050362083,-0.016945176,-8.671477e-33,0.080659114,-0.111008376,0.08886766,-0.11597572,-0.09094862,0.011083036,0.0723212,-0.06119435,0.04900945,-0.07572408,0.06796358,-0.007556189,0.06400153,-0.02098264,0.014840962,0.043421283,0.0032531286,0.06702969,0.028117096,0.047125068,0.022327425,0.039482437,-0.022420729,0.053343147,0.006652314,0.062022507,-0.031462416,-0.010494156,0.09632461,0.03145838,-0.04508999,-0.023938248,-0.10116132,-0.07055181,-0.06405638,-0.031965274,0.02885678,0.029301787,-0.09524123,-0.027644811,-0.05364007,0.006381597,-0.018873243,0.10801918,0.072267614,0.04098423,-0.025556622,0.02849201,0.0013668197,0.030981267,0.0629091,-0.079466715,0.002914329,0.074952945,0.02104518,0.04958486,-0.014656418,-0.084182195,0.009405566,0.0034248396,-0.0155103365,-0.031311125,-0.02391545,-0.047479603,0.06561527,0.034636006,-0.011005514,0.065514125,0.084077634,-0.053690996,0.042325787,0.037454925,0.024590814,-0.039923407,-0.077403255,-0.008525713,-0.036602847,0.013252515,-0.006527169,0.05895951,0.02113957,0.038743902,-0.032171726,0.0104903625,0.07030787,0.0017216891,-0.033921074,0.078027725,0.0379374,-0.041023843,-0.050718643,-0.006063001,-0.014295206,0.014486832,0.030673275,-4.021209e-08,0.036511138,-0.06481807,-0.02939181,-0.08194651,0.012691784,0.051191095,0.016020138,-0.0336825,-0.055791564,0.01815782,0.02631487,0.12184898,-0.053670388,-0.059489053,0.0431815,0.05446315,-0.06618839,-0.017761996,0.015146289,-0.0013234303,-0.04224339,-0.039795775,-0.049129155,0.08730419,-0.014357483,-0.03833729,0.069442794,0.029049298,-0.028305436,0.07448381,0.063327454,-0.045944817,0.038712934,-0.056133784,0.05735474,0.027356109,0.033675738,-0.042004876,-0.04678405,0.029659962,-0.030001571,-0.012072123,-0.0320711,0.059831437,0.027653614,-0.08196438,0.00046276057,0.10057395,-0.0063991067,0.0065621333,0.012844635,-0.05733535,-0.01973793,-0.051149923,-0.12228924,-0.035197183,0.023028126,-0.04658587,0.00991129,0.005316539,0.0098976195,-0.043944694,0.13890664,0.009880592 +1.7.3.1,"Has an absolute requirement for FAD [4]. While nitroethane may be the physiological substrate [2], the enzyme also acts on several other nitroalkanes, including 1-nitropropane, 2-nitropropane, 1-nitrobutane, 1-nitropentane, 1-nitrohexane, nitrocyclohexane and some nitroalkanols [4]. Differs from EC 1.13.12.16, nitronate monooxygenase, in that the preferred substrates are neutral nitroalkanes rather than anionic nitronates [4].",384,0.99999994,-0.052717265,-0.10955794,-0.08840852,-0.05453138,0.09183702,-0.030072838,-0.07827981,0.06346625,0.014852145,-0.064263456,-0.061624106,-0.045020863,-0.07398251,0.08123534,-0.021847727,-0.0034000003,-0.010788222,-0.066134036,0.017411813,-0.033050552,0.015490328,-0.021948641,0.02707024,-0.062825374,-0.035078205,-0.035043422,-0.0077958643,-0.07759346,0.036561232,-0.053553328,0.05595592,0.03808737,-0.006229797,-0.053961255,-0.03162806,0.075846694,-0.028813155,0.03662789,-0.016764222,0.0017997947,0.04244777,-0.021263156,0.0032851782,-0.04827314,0.019843148,-0.033156943,0.00022034884,-0.048227116,0.011307997,-0.0070949453,0.01292172,-0.04690001,-0.012676995,0.023928514,0.053801227,-0.04394099,-0.06847222,-0.09719825,-0.03555048,0.07448343,0.019359458,0.01992285,0.014674446,-0.027181488,0.042944524,-0.015416445,0.032392558,-0.056188315,-0.014346892,-0.07182911,-0.058333263,-0.07144104,-0.0118406145,-0.03497233,-0.028328313,0.02765902,0.001313293,-0.034589827,0.055545103,-0.06608967,0.0031739452,0.05075707,0.104164965,0.04680752,0.051787157,0.011747813,-0.00897811,0.007146978,-0.019552646,0.103255734,0.04059271,0.043718483,0.056299556,0.004411225,0.00020354656,0.036911484,-0.028856188,0.057473864,-0.01380434,-0.034358248,0.0075068055,0.032012668,-0.06794347,0.018353349,-0.12118815,0.0045309346,0.0003685787,0.044517137,0.077104636,0.00850826,0.0010503993,-0.008750779,0.04792209,-0.013349239,-0.06447368,0.03952531,-0.0045762206,-0.05882067,0.02709127,0.048295412,-0.04195604,0.014510493,0.05704256,0.042748466,-0.013383627,0.078030795,0.0031443154,7.376417e-33,0.030544778,0.021824835,-0.01875247,-0.0876305,0.018099573,-0.014910528,-0.1263818,0.018358666,0.02910721,-0.05077393,0.038991436,-0.0052570277,-0.0013351886,-0.03073679,-0.029922185,0.0077411635,-0.007696751,0.011091065,0.04716787,-0.04083855,0.005554979,0.038918495,-0.04875866,0.050296858,0.033852696,-0.003454988,-0.06556242,0.087241806,-0.016808454,-0.021987636,-0.05442065,-0.103230216,-0.027239615,0.03559898,-0.002074135,0.0044344855,-0.022976598,-0.026965098,-0.07603396,0.01609982,-0.010932697,0.066827,-0.02375697,-0.046599124,0.07444866,-0.015506854,-0.102641135,0.13133575,0.024320986,0.09556778,-0.005032333,-3.9582847e-06,0.071539536,-0.073543705,-0.02344386,0.023820836,-0.059410248,0.013955489,0.13907605,-0.018173387,-0.048804145,0.015729401,-0.011423756,0.018810991,0.00934506,0.067202896,-0.031180535,-0.02533636,-0.023036238,0.083914205,-0.049250722,0.027490547,0.023770433,0.015874175,0.117841125,-0.07567019,-0.029249182,-0.016915793,0.060664937,0.008247698,0.012296653,0.051341984,-0.045557845,-0.06891421,-0.03229725,-0.008794348,-0.07120861,-0.043080166,0.056494478,0.03353205,0.059993524,-0.09351841,-0.04661022,0.028924663,0.03861143,-7.768598e-33,0.04246335,-0.057110593,-0.014958401,-0.093424246,0.013355913,0.113824695,0.064211965,-0.056102265,0.0084259305,-0.037411585,0.07352055,-0.009181423,-0.015881987,0.010219519,-0.025577735,-0.008960304,-0.04249704,0.046615455,0.04225023,0.01621413,-0.022669693,0.086631924,-0.061249886,0.07407255,0.07359124,0.039292544,-0.0753355,0.047805876,0.098675884,0.030530106,-0.005118082,0.043405175,-0.07748089,-0.004427486,-0.003931575,0.014490269,-0.030926565,0.041291762,-0.045005973,-2.1193096e-05,-0.0037503866,0.07529267,-0.0050380994,0.08788974,-0.02198981,0.07046377,-0.1455572,-0.03844059,0.05561048,-0.09558719,-0.029972654,0.07311763,-0.0052621253,0.007581673,0.0120181795,0.042505022,0.09401422,0.05679619,0.04633778,-0.035801347,-0.025436336,-0.084624305,0.009502159,-0.0027991766,-0.0061102537,0.026272833,-0.019534776,0.108782746,0.03337607,0.0249183,0.04567882,0.028089285,0.08726835,0.043541316,-0.06787187,0.025187492,0.12751336,-0.057762004,-0.010816918,-0.01650746,0.054765347,0.07140606,-0.051599678,-0.023762073,-0.10850681,-0.053044476,0.100339174,0.045774415,0.03200175,-0.014108865,0.011168533,0.055300787,-0.088901825,-0.021289788,0.03478768,-5.4947723e-08,0.03519444,-0.0954929,0.065969154,-0.010357029,-0.041219868,0.039673924,0.0050341845,-0.055851534,-0.0064912527,-0.024842268,0.039873466,0.100225516,0.01922053,-0.0052065533,0.0875867,-0.05988383,-0.023324413,-0.004685321,0.0011772759,0.024314947,-0.087461635,0.033853464,-0.10317512,-0.019309243,-0.058126066,-0.106307365,0.037953287,-0.013325845,0.009889351,-0.0049962965,-0.07694641,0.07556527,0.012746964,-0.030466652,-0.052337375,0.013624344,0.009234209,-0.010498119,-0.08234249,-0.02187062,-0.0033031984,-0.0539513,-0.06764667,-0.0314302,0.031082097,-0.005355515,0.018250605,-0.014193012,-0.026604846,0.010817766,0.04114676,-0.0716102,0.023435276,-0.04250141,-0.05315236,0.046124585,-0.06252021,-0.062900394,-0.05511153,-0.09186315,0.039673034,0.016675277,0.15479133,-0.013683016 +1.7.3.3,"This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase).",384,1.0,-0.0913307,-0.048976067,-0.034328014,-0.009165657,0.08359293,-0.038425278,-0.07649454,0.04644827,-0.003972986,-0.07522435,0.042772237,-0.06323524,-0.05263876,-0.020302106,-0.10653785,-0.06898719,-0.0037336561,-0.040659145,-0.009779499,-0.05768967,0.12997925,0.052304197,-0.02506328,-0.043358497,0.006347009,0.030827915,0.070512295,-0.06440278,0.004526576,-0.10270858,-0.038877666,-0.0647968,-0.035098575,-0.020432519,0.04340089,0.05510767,0.00029874351,-0.06129093,0.04653724,-0.03352665,0.06495913,-0.017396444,0.10483601,-0.052343056,0.03017666,-0.032890376,0.0062005348,-0.030007882,0.02865606,0.014780782,-0.077282794,-0.060323443,0.015737195,0.037886415,0.07572099,-0.025797816,-0.05559206,-0.06288774,-0.01249034,0.004878429,0.023738217,-0.026935728,0.0417582,-0.0013968387,0.014668597,-0.009575403,-0.034303136,-0.09860419,0.013122959,-0.07648125,-0.03099582,-0.047775313,-0.028894024,0.046097763,0.0018763328,0.11262034,0.028850919,-0.04367149,0.08586655,-0.02378602,0.023279896,0.043635696,0.08362533,0.05474943,0.025183639,-0.018055907,0.020189548,0.0136109525,-0.04576175,0.015646178,0.06999014,0.055195313,-0.0175404,-0.0046704053,0.03835617,0.064452976,0.0037008047,0.00718841,-0.04225281,-0.062228676,0.00036705306,0.087397315,0.014243797,-0.06642248,-0.064626865,-0.0032142657,-0.010709883,0.12933758,0.084434584,0.03894767,-0.0074428553,-0.007873749,0.024530245,-0.030523395,0.015185167,0.041493643,0.028505128,0.0027163527,-0.051789835,-0.030747235,0.014154109,0.05518212,0.020825991,0.05870442,-0.039290063,-0.013273104,-0.0684487,2.8745403e-33,0.058351725,0.010081218,-0.056064054,-0.041561518,0.024917819,-0.01628788,-0.08688605,0.039078254,-0.010248849,-0.057418,-0.09009832,-0.022571752,-0.031910848,0.0090946555,-0.0244325,-0.011178314,-0.03576977,-0.0047726003,0.081876464,-0.06615867,0.07715787,0.07589163,-0.0143569885,0.031913094,0.002337333,0.014797802,0.040337604,-0.031645413,-0.017809825,-0.010946082,-0.006455414,-0.06310594,-0.0466021,0.023212852,0.06304727,0.016150348,0.042677794,-0.012179124,-0.025461178,0.117729984,0.0350493,-0.008353066,0.049521033,-0.04760031,0.047962293,-0.10549795,-0.09174107,0.10366267,-0.000641733,0.02355158,0.018804256,0.0014473536,0.08661732,0.014640528,-0.038882833,0.003806712,-0.054989137,0.034108065,0.040418036,-0.009511359,0.014393496,0.07419247,-0.00940013,0.09380502,-0.10230586,0.017458566,-0.039303932,-0.025829319,0.02656451,0.107336074,-0.028084628,-0.021602003,0.05127554,-0.038334556,0.06622536,-0.089610405,-0.0599734,-0.030317424,0.073535904,0.078334585,-0.0237947,0.021251833,0.08359889,0.008514487,-0.037341457,0.0047853137,-0.04297096,0.027145859,0.02637486,0.001911836,0.052049424,-0.03126937,-0.09768492,0.024269514,-0.0099271685,-3.2148345e-33,0.13179314,-0.10408307,0.09578688,-0.070340306,-0.06124205,-0.03750371,0.062503055,0.024248697,0.072232,-0.05996847,0.13077135,-0.018268002,0.046520144,-0.07864556,0.059547715,0.045540135,-0.07876422,0.061395574,0.03879565,0.008028711,-0.06261474,0.039051708,-0.030488012,0.024827302,0.062053375,0.033516817,0.017518897,0.03571774,0.055386875,-0.009287806,-0.04491663,0.028483965,-0.048743706,-0.020062959,-0.09445543,0.07766608,-0.030862037,-0.012344341,-0.0049842396,0.017646577,0.038245466,0.01499277,-0.023091963,0.04040133,0.056856822,0.063956045,-0.047412716,-0.008955964,-0.05174873,-0.022744957,0.060305536,0.0190369,0.015025097,0.008777224,-0.00014458908,0.04023286,-0.016255287,0.038334742,-0.01858969,0.051284503,0.021635976,-0.032474708,0.014801119,0.00040854746,0.05890516,0.08593748,-0.023535881,0.049107958,0.0032135209,-0.025414532,0.099645086,-0.0061670826,0.015937123,0.00487,0.059215344,-0.04309759,-0.039406184,0.04348654,-0.004819002,-0.06858479,0.009208382,0.04260688,0.021560332,-0.01518452,0.018402055,-0.028982889,-0.007864527,0.15932846,0.012543317,0.05887851,-0.08996333,-0.04144396,-0.035406943,0.04503482,0.09972247,-4.3569862e-08,-0.020802805,-0.0021101476,0.033265162,-0.044473153,0.021165242,0.08320809,0.019222535,0.0077535044,0.06790219,-0.038679708,-0.07374775,0.049941532,-0.04517037,-0.0041398755,-0.037566293,0.022396818,-0.029508714,-0.024022274,0.033781845,0.006337586,-0.06638878,-0.032610293,-0.10071138,0.022434967,-0.056212794,-0.032349374,0.006272444,0.06744741,-0.08727864,-0.013855301,-0.0625082,0.054060057,0.036013015,-0.054217804,-0.09362869,0.037571568,0.009400153,-0.049161833,-0.038506687,-0.040669266,-0.06420398,-0.049544357,-0.016273864,-0.055753905,-0.018076167,-0.05741484,-0.037353188,0.07493819,0.055029187,-0.03867455,0.0226198,-0.015593253,0.0012513739,-0.08445341,-0.015432817,-0.02280339,0.030087296,-0.084640175,-0.046973113,-0.0149813,0.045919135,-0.052478988,0.15745135,-0.051633354 +1.7.3.4,"The enzyme from the heterotrophic nitrifying bacterium Paracoccus denitrificans contains three to five non-heme, non-iron-sulfur iron atoms and interacts with cytochrome c556 and pseudoazurin [2,3].",384,1.0,-0.08218358,-0.0590501,-0.1377889,0.0015376761,-0.007605201,-0.016227435,-0.00014837316,0.025641354,-0.033022806,-0.007958112,-0.02674713,-0.07131353,-0.014421139,0.061665162,-0.08154553,-0.041936357,-0.08161914,-0.05286238,0.014421156,-0.023571948,0.030854244,0.06174134,-0.07089535,-0.044716224,-0.003808134,0.021867868,0.04470506,-0.02271996,-0.058751576,-0.008329871,-0.047324482,-0.05811203,-0.001307785,-0.049356904,0.15714793,0.022423983,-0.024903875,-0.016550897,0.0726284,-0.019969665,0.018811427,0.038345568,-0.024378086,0.02763508,0.016897162,-0.031430177,0.025780601,0.070000984,0.036295492,-0.06762838,-0.035098605,-0.012076754,-0.018331908,0.10260894,0.03986703,-0.030239608,-0.057554476,-0.0497154,0.051622696,-0.023654852,0.03926335,-0.020424165,0.0052025905,-0.03318748,0.017453583,0.022617757,0.06099632,-0.040555507,0.00982252,-0.009724813,-0.06361732,-0.0044525387,0.009081238,-0.009435146,-0.023198457,0.028537063,0.07457099,-0.06476079,0.0149577055,-0.09079046,0.032888986,0.021863258,0.028752204,0.12032964,-0.015051339,-0.015110303,0.038418658,-0.058331184,-0.0100149615,0.051569134,-0.011177482,0.030244231,-0.0043413155,-0.10448382,-0.09039052,0.039830618,-0.047108468,0.1254233,0.0019871371,0.011302262,0.012433217,0.044739746,0.02534027,-0.08648621,-0.040670026,0.000559162,0.01547539,0.120593466,0.12285202,0.090026125,-0.025070747,0.016997322,-0.025156038,-0.046866924,-0.021829786,0.06644431,0.13505958,-0.026656602,-0.08666358,-0.004709929,0.019918317,-0.008885781,-0.0087468205,-0.030531209,-0.0071644736,0.03994392,-0.10105928,2.9299536e-33,0.06964336,0.018944874,0.024462482,-0.009414584,-0.030198965,-0.01832934,-0.112157695,0.021132533,0.017443066,0.008732963,-0.09047491,-0.055579018,0.027933817,-0.015135055,-0.013276783,0.023596616,-0.008254221,0.015624454,-0.029693915,0.045009624,0.033045363,0.07357421,-0.039279666,-0.048346028,0.037523355,0.039313704,-0.004118188,-0.021937398,0.032703824,-0.0335172,0.055170603,-0.095801786,-0.06692994,0.005944272,0.16296679,-0.023918549,0.037860498,0.024283411,-0.026374435,0.012894255,0.019980935,0.061008677,0.018011242,0.004947565,0.03183853,-0.07979073,-0.039990667,0.05960953,-0.03513123,0.05326476,0.019878458,-0.016531993,0.07909917,-0.022519995,-0.009531857,0.019054973,0.028687766,0.038065996,0.12148413,0.0042468742,0.06311566,-0.0072754384,-0.024146166,0.03833236,0.12767798,0.027374139,-0.04779349,0.05803084,0.0884229,0.06543103,-0.1586494,0.07698494,0.034143075,-0.0010343659,0.01457472,-0.056601197,-0.054695375,-0.034983292,0.07583085,0.0064423573,0.021887636,-0.07253993,0.03108454,-0.04427303,-0.03545516,0.014414221,-0.035312667,0.017243525,-0.009286397,-0.063939154,0.055579204,-0.026780922,-0.09880359,-0.09151914,-0.026429117,-3.0984896e-33,0.088519245,-0.025621476,-0.00082884904,-0.05319498,-0.06185273,0.044599984,-0.03276078,0.001995543,-0.023685591,0.0011623304,0.14600538,-0.0047377357,0.060801484,-0.019213803,-0.0032266907,0.009108011,-0.029910496,0.01732106,-0.03085395,-0.06256641,-0.008626787,0.006150581,-0.019112896,-0.08524658,-0.0032059993,0.04027135,-0.024857974,0.077306256,0.070755035,0.04187522,0.016537178,0.05157035,-0.05204359,-0.11332677,-0.0072526853,0.022573864,-0.0013971925,0.027636187,0.03385455,-0.04086193,0.009331357,0.01721552,0.002174081,0.15748322,-0.0032845987,0.033768307,-0.10944034,-0.032286353,0.029872227,0.040601354,0.038688015,-0.033452462,-0.07227671,0.011095323,0.042786203,-0.0030457655,0.020259997,0.060797982,-0.026147546,0.02976199,-0.066595025,-0.03209534,0.023930153,-0.008121271,0.020918265,0.015077977,-0.02023702,0.048538703,0.03538491,-0.04860771,0.004673064,0.06297299,0.024952643,-0.076176636,-0.08179713,-0.05690184,0.04883104,-0.0009729092,0.029620789,0.02201853,0.025343893,-0.004381324,-0.04053456,-0.025535693,0.051643882,0.0017912472,0.00843255,0.028189242,-0.09085636,-0.011708597,-0.04803695,-0.010286826,0.05318677,0.0034244277,-0.08454895,-3.1773293e-08,0.04066862,0.029517824,0.001382798,0.0001833798,0.041227005,0.079906456,-0.04508109,-0.04792973,-0.0009331504,0.018427305,0.062489174,0.026796008,-0.050820783,-0.019216308,0.03780114,-0.00536793,-0.027345678,-0.013211282,-0.034416817,0.037355088,-0.012514693,-0.012834615,-0.13440636,0.069696724,0.08056468,-0.066348486,0.05448843,-0.055839643,-0.015560102,-0.010512375,-0.0262947,0.052242182,-0.0070002982,-0.025031317,-0.047799867,-0.029415237,-0.029644735,0.03625494,-0.06595222,-0.02733522,0.02067658,-0.021623576,-0.13765453,-0.012856872,-0.047315795,-0.034887128,-0.01191586,0.041020483,-0.04959544,0.0520886,0.03452147,-0.03515522,0.046017833,-0.02261353,-0.067591995,0.07594916,0.106363416,-0.03175633,-0.027758881,0.079150744,0.029721782,-0.035801586,0.07602201,0.040377587 +1.7.3.5,"A flavoprotein (FMN). The primary products of the enzymic reaction are probably the nitropropanoate free radical and superoxide. Also acts, more slowly, on 4-aci-nitrobutanoate.",384,0.99999994,-0.054668605,-0.044608988,-0.13263619,0.051900543,0.10282245,0.034672335,-0.019934498,0.06305011,0.042625394,-0.0641453,0.04250153,-0.011371786,-0.10536411,0.008186391,-0.09507613,0.07971331,-0.04763161,0.0019402595,-0.09532465,-0.06753176,-0.005759994,0.012645708,0.056163106,-0.03157722,-0.030134557,-0.030750122,0.011754301,-0.06931646,0.012800265,-0.045892112,0.09358573,0.05636736,0.07922134,8.547913e-05,0.00447867,0.024525369,0.007878317,-0.07757204,0.019934949,-0.014632672,0.059449807,-0.0424116,-0.00020652103,-0.044642776,0.075995915,0.0038567774,0.017455656,0.061199825,0.033460774,0.07935516,-0.03589285,-0.03007881,-0.09038555,0.08405009,0.07580512,0.009452061,-0.063698106,-0.07443085,-0.037626307,0.11585938,0.022352144,0.01742612,-0.029024588,-0.019635484,0.03074827,-0.019227237,-0.005643184,-0.018004417,-0.01229857,0.0045248764,0.027984342,-0.03387476,-0.06579061,-0.010494448,0.017883347,0.035930905,-0.017584715,-0.032016966,0.045432635,0.013342054,0.06335171,0.00821429,0.049026746,0.08872722,0.06600801,-0.04510031,-0.04674415,0.026956446,0.008071363,0.0987105,-0.079036064,0.04945262,-0.0028247805,-0.022468664,-0.024542306,0.074951075,0.028251655,-0.009362361,-0.020825122,0.027165536,-0.021965051,-0.0509033,0.039437067,-0.08072727,-0.097269714,0.010892191,0.024583392,0.023134517,0.04534102,0.021625323,0.009984829,-0.01597786,0.0050570485,-0.0690292,-0.035593,0.054614704,-0.028916271,-0.043313757,-0.03884179,0.023715658,-0.012770619,0.10744741,0.020657837,0.09847194,-0.044070516,0.078359365,-0.0960668,2.6173965e-33,0.03768726,0.05983467,-0.014345749,-0.017288204,0.008261708,-0.008923899,-0.011786613,-0.00072754116,0.03725531,-0.006522946,-0.07890084,-0.0035273419,0.010701525,-0.047171492,-0.011184441,-0.06912265,0.0058809677,0.0019784523,0.031171046,-0.02170941,0.021657437,0.045238737,-0.059085082,0.0388385,0.003570966,-0.042995274,-0.0634916,-0.03511372,-0.011169543,-0.0145815825,-0.01531777,-0.02933694,-0.012330136,-0.053503618,0.037101347,-0.046222474,-0.030165507,-0.065922104,-0.047425,0.09775459,-0.018147595,-0.015393669,-0.06476992,0.019282937,0.040055107,-0.013660692,-0.13358077,0.09592511,0.05307901,0.06490906,0.06258053,-0.008537419,0.078224726,-0.007136095,-0.04368698,0.018706715,-0.008231653,0.028420454,0.050964486,0.014184073,-0.091884494,0.04160508,-0.03182978,0.039049786,-0.017097998,0.0013468051,-0.008187801,-0.026110249,-0.0045144456,0.017576229,0.016744426,0.008165466,0.08403112,0.008623506,0.05691021,-0.025619991,-0.06647639,-0.0004891603,-0.037728094,0.0405706,-0.026605837,0.043954805,-0.02197401,-0.034737032,-0.067598164,0.007620387,-0.084426,-0.004386003,-0.025890779,-0.004432236,0.050286844,-0.042573873,-0.041633155,-0.022589926,0.06178553,-2.1106947e-33,0.002739004,-0.117766865,-0.0381191,0.004451798,0.015505203,0.0645421,-0.039312474,-0.058383346,0.008230127,0.031431884,0.041573245,-0.11270763,0.012376864,-0.009501259,-0.00039534684,0.037916947,-0.02570189,0.10515604,0.055415228,0.008478638,-0.016408999,0.03788532,0.0526222,0.09955886,0.047887277,0.032230847,0.029358309,0.02557189,0.064007066,0.08251575,-0.06505707,-0.03592762,-0.062365543,-0.061561655,0.041203864,0.07368636,-0.0014466154,-0.043055173,-0.022665823,-0.012902031,0.0306914,0.03256391,0.07549693,0.11521,-0.01820952,0.056618303,-0.073623665,0.016338222,0.036934838,-0.002200765,0.011472715,0.025225794,-0.05967579,0.057103224,-0.0017362242,0.041829653,0.08040322,0.013227937,0.005509311,-0.0079531595,-0.03401704,-0.1192127,0.023562009,-0.026817461,0.06532729,0.07516158,0.06868305,0.108497955,0.03576026,-0.020205699,0.09774389,0.018258214,0.06575913,0.047401853,-0.0040159645,0.010199262,-0.0042673484,0.003376141,-0.015615043,-0.0331753,0.01246959,-0.02690465,-0.026627146,-0.07086439,-0.07196927,-0.07058416,0.022760142,0.04835032,0.055050388,0.014462389,0.008710741,0.032599982,-0.09874984,-0.019342406,-0.0008879351,-3.310646e-08,0.044813436,-0.10068392,0.036395423,-0.0052738227,0.06448028,0.036162443,0.010224448,0.043620028,-0.010366179,-0.041646626,-0.02055862,0.10269305,-0.0139863035,-0.019594107,0.06053687,-0.076474145,0.021998692,0.017308258,-0.020344418,-0.06215334,-0.043958634,0.07783579,-0.040273555,0.0027290308,-0.10648835,-0.076973066,0.03048511,0.02179271,0.076473504,-0.023461217,0.037790876,0.03169625,-0.022315437,-0.05662689,-0.16748545,0.0038530268,0.047511347,-0.0321801,-0.071757816,0.018647222,-0.1478953,-0.016948031,-0.031012917,-0.025719637,-0.08739179,-0.03259011,0.058975913,-0.00882091,0.012675479,0.00065139396,0.007587317,-0.028775305,-0.020013738,-0.014004107,-0.09634747,0.0046130605,0.039319705,-0.0006444818,0.039966352,-0.06345429,-0.10448927,0.029901901,0.14788789,0.07195694 +1.7.7.1,An iron protein. Contains siroheme and [4Fe-4S] clusters.,384,0.99999994,0.033063322,-0.07474116,-0.08650036,0.109731466,0.08059692,0.043929093,0.02739055,0.03064486,0.015534483,-0.055658996,-0.018142372,-0.0398849,-0.03321425,0.004456742,-0.045908667,-0.028807629,0.0023981705,-0.019793477,-0.026075942,-0.041512042,0.028780188,0.03387476,0.045439303,-0.044514764,-0.079006605,0.062489886,0.08706492,-0.0227402,-0.015991552,-0.05340852,-0.031862848,-0.044390053,0.088416874,-0.045070942,-0.015768377,0.07908389,0.067207776,-0.04507995,0.027117282,-0.01662926,0.0063830204,-0.009992915,0.041618932,-0.015539462,0.0066034338,-0.00607829,-0.020513358,0.01685253,0.067621686,0.06799188,-0.029315468,-0.069418654,-0.020845415,0.07383049,-0.006200069,0.023586677,-0.039863173,-0.06683135,-0.025080102,0.054733526,0.051778607,-0.08077365,-0.010362867,0.01732528,0.047475945,0.01938478,0.035216197,-0.04013731,0.013372375,-0.041413177,0.034506414,0.027966881,-0.04572751,0.043342516,-0.01754843,0.10346375,0.060806658,-0.0922794,0.1367637,0.035921264,-0.0736206,0.034215022,0.08065146,0.10461195,0.0583048,0.023247315,-0.013905342,-0.1030909,-0.109927274,-0.015787728,-0.04880666,-0.0070427395,-0.034117967,-0.051200617,0.028620476,0.038786776,-0.008882716,-0.005072937,0.013470842,0.0066758594,-0.041056816,0.0521053,-0.047800746,-0.08107069,-0.053963263,0.025732126,-0.069018275,0.087835096,0.049904168,0.04958687,0.014505795,0.009292995,0.032409184,-0.024460165,-0.032915458,0.010996662,0.08392361,-0.012238457,-0.05692424,0.05471626,0.02649788,0.08043254,0.029487543,0.04639762,-0.041745175,-0.058133587,-0.102231584,-2.7624367e-33,0.017951371,0.02349843,0.059274465,0.00753635,-0.018791303,-0.015444187,-0.06787658,-0.02249213,0.020076673,-0.015143911,-0.06348648,-0.020737538,0.0757941,-0.032191213,-0.0057922737,-0.08264384,0.031399623,0.017271595,0.056528512,-0.0863872,-0.0042266147,0.16940057,0.07090978,-0.005988636,-0.033444587,0.034244567,-0.03381628,-0.0549802,-0.003238014,0.015132446,-0.03915309,-0.017387634,-0.10259696,-0.07346967,0.0073184213,-0.016155947,0.01581578,-0.10396999,-0.048404474,0.022774348,0.026681071,-0.005646017,-0.043929834,-0.06260294,0.050531317,-0.11209477,-0.06444212,-0.012077548,-0.0020892818,0.0072071007,-0.02763559,-0.021133592,0.07500219,-0.015384753,-0.05213737,-0.061184313,-0.014593167,0.03408466,0.017088389,0.095880955,0.039823472,0.007044549,-0.0075007323,0.08713644,0.037851196,-0.025110308,-0.064472824,0.023596412,0.010873861,0.10392926,0.015640043,0.057323504,0.109301984,-0.03484532,-0.025498984,-0.07318555,-0.06610627,-0.003155089,0.030685466,0.049360245,0.0042668716,-0.073968776,-0.049269777,0.019890832,-0.047131546,0.026085299,0.008039825,-0.045714375,0.06503619,-0.07125799,-0.002973208,0.006954763,-0.06858839,-0.0030267204,-0.088630766,-7.7455424e-35,0.03801329,-0.024691757,0.021503998,0.029718976,-0.045082547,0.036087487,0.024023568,0.021460833,-0.04025335,0.051375248,0.13136758,-0.0826914,0.023732087,-0.14324495,-0.012485519,0.12580891,-0.037949156,0.047325276,0.09859709,0.031613566,-0.06536449,0.015664803,0.040412184,0.06602979,0.06932432,0.023342483,-0.013120379,-0.043643292,-0.008104593,0.12804945,0.009015851,-0.040304035,-0.050918054,-0.08192215,-0.021354793,-0.013209787,0.018842217,-0.04409835,0.06154246,-0.03259451,-0.005817491,0.039057124,0.06738375,0.124838874,0.07098635,-0.00803755,-0.06530723,0.060590323,-0.0396092,-0.0076339673,0.03209828,-0.08503263,-0.058183063,0.018269746,-0.0379854,-0.019964676,0.00044536378,0.08301487,-0.022353578,0.07850549,-0.03457392,-0.08315412,0.06971132,0.011528139,0.06261007,0.05496144,-0.04987417,0.03362992,0.0006038901,0.039607238,0.05280324,0.009519334,0.07641814,0.019692972,0.05883698,-0.019661404,-0.008424561,-0.0398577,-0.09049547,0.04589538,-0.06025321,0.01432209,-0.017798912,-0.035405878,0.06604856,-0.06671011,0.012172728,0.079931945,-0.008011339,0.027873136,-0.06735205,-0.0070905257,-0.039242506,-0.014793061,-0.008180274,-2.1339215e-08,0.063537546,-0.04309218,-0.016624171,-0.050882902,-0.029900625,0.0014800535,-0.031508263,-0.04771105,-0.004771677,-0.013748872,0.020610675,0.070874214,-0.05763955,-0.02971656,0.048063874,-0.0010805519,-0.019618345,0.06017574,0.009384908,-0.0007224875,-0.05724672,0.003082542,0.024371214,-0.019825257,-0.02221779,-0.044771634,0.00674645,-0.027851835,0.009884829,-0.05148519,-0.017085696,0.053686783,0.0036270788,-0.028027711,-0.09560459,0.040698458,-0.032091204,-0.007117227,-0.07682011,0.04928149,-0.034290943,0.012601138,-0.073847815,-0.008863524,-0.026044283,-0.024631396,-0.054606304,0.08152903,0.019387161,-0.0026366108,-0.03422561,-0.011902994,0.06406076,-0.0017999641,-0.06612696,0.044398073,-0.028726378,-0.08254289,0.09036765,-0.022159362,0.00326661,-0.04601704,0.07799674,-0.057267584 +1.7.7.2,A molybdenum-iron-sulfur protein.,384,1.0,-0.06326358,-0.069993734,-0.113616034,0.069243,0.05016624,-0.0004623399,0.032349773,-0.01183474,0.027407568,-0.11072062,0.021125967,0.036538146,0.008697821,-0.013317375,-0.06185862,0.004027372,0.027650366,0.014175708,-0.01500937,0.029085007,0.031459615,0.030012514,0.022241954,-0.056253057,-0.02264657,0.06654184,0.019435564,0.014273192,-0.014265371,-0.079552904,0.02806998,-0.006674215,-0.0050592734,-0.058511134,0.03817439,0.033040356,0.018711723,-0.034815002,-0.008229983,-0.027154041,0.0003506663,0.049117163,0.029125735,-0.05773366,-0.023643622,-0.058381416,0.025857192,-0.0017478624,0.040988725,0.048077863,0.0012117756,-0.08165302,-0.04787028,0.094346814,0.039270956,-0.0029970766,-0.08968536,0.041407544,0.02536085,-0.029135417,-0.027667198,0.037869886,0.07483259,0.021029511,0.021593422,-0.042748895,0.0057029016,-0.06755749,0.02096429,-0.055723645,-0.019771425,0.027464133,0.012785982,0.072484694,-0.050427683,0.10612347,0.041505966,-0.042695682,0.15334858,0.023876755,-0.031745456,0.043221008,0.027835162,0.11676274,0.032972034,-0.03572423,-0.0133055365,-0.002954381,-0.058225796,-0.00805219,0.020791853,0.00937396,3.994612e-05,0.013690906,-0.06946515,-0.0009303326,0.04461622,0.051045984,-0.1050379,0.02790622,-0.041302815,0.024315769,0.018188886,-0.09277526,-0.039735563,-0.054043144,-0.026886072,0.13196535,0.014076086,0.0318334,0.0028373355,0.0056894063,0.04199137,-0.08227542,0.017136028,0.011783918,0.06261607,0.022960827,-0.08063126,-0.035876047,-0.015416328,0.071357615,-0.029905163,0.01790324,-0.07816998,0.012686501,-0.07437543,-2.6263315e-33,0.12348942,0.036580887,0.110156536,0.02876426,-0.028379424,-0.06651087,-0.075954825,-0.0070223087,0.005516856,-0.014652707,-0.034931827,-0.072719015,0.039783586,-0.031456646,-0.00047713175,-0.031786405,-0.03928969,-0.08697342,0.08410496,-0.005038279,-0.043672107,0.12905516,0.06897341,-0.005510322,0.049393438,0.01884695,-0.00538089,-0.035058312,-0.018862491,0.02393769,0.034872048,-0.0920676,-0.09362593,-0.040840402,0.04922308,-0.03795333,-0.033708736,-0.057050884,-0.015439965,-0.033733506,-0.0044096927,-0.023970922,-0.04065548,-0.04412849,0.03636377,-0.0412943,-0.02586188,0.11447505,0.012287684,-0.0056409277,-0.00011049381,-0.031481244,0.0058925506,0.03157294,-0.12857215,0.020495657,0.0045522293,0.0046064155,-0.025852824,0.09112945,-0.0013914437,0.050517786,0.03154813,0.060385242,-0.022950578,-0.042590737,-0.10381974,0.013101621,0.025891438,0.051778898,-0.033471145,0.014487256,0.08125401,-0.023947507,-0.032033574,-0.04071151,0.040712222,-0.110588655,0.05468713,0.06084934,-0.0026945756,-0.058421776,-0.0025389735,-0.027050398,-0.08535881,0.02179289,-0.06466991,-0.015703473,0.045229964,0.015393922,0.020480994,-0.020790152,-0.07795112,0.00937493,-0.11780531,2.169157e-34,0.048445757,-0.08780941,0.091017544,-0.0065478184,-0.0543789,0.0017734637,-0.010825242,-0.033068147,-0.021828769,0.032773476,0.056368243,-0.022501811,0.040677544,-0.0895136,0.035490885,0.1080926,-0.01137359,0.019121848,0.058357503,-0.0024431706,-0.015153708,0.04472149,-0.02092467,-0.020541407,-0.007997203,0.06943904,0.021589423,-0.0385371,0.057173945,0.10072293,0.048703674,0.01206056,-0.05822849,-0.15145971,-0.061742958,-0.016942007,0.0001741433,-0.02864459,0.0026145934,-0.04827756,-0.024477659,-0.012424879,0.051242765,0.12660079,0.08330314,0.028049244,-0.04847412,0.008417175,0.010790369,0.053784467,0.006680382,-0.06904666,0.009474868,0.039791368,-0.029587755,-0.008636056,-0.043999717,0.04311783,-0.01616286,0.05708364,-0.0057183146,-0.034173816,0.035198927,0.011573729,-0.012356636,0.107114196,-0.0046908827,-0.028938875,0.033042807,-0.051958174,0.021480272,0.005156039,0.0059946105,0.0070420215,0.098393865,0.011349215,-0.035952657,0.08316972,-0.054238625,0.050818786,-0.075484015,0.04699959,-0.013158861,-0.055038847,0.1239291,-0.023147358,-0.016357409,0.11411503,0.031338185,-0.004200323,-0.0934788,-0.006053922,-0.05801444,-0.0019205607,-0.008399786,-1.7749603e-08,-0.051758688,-0.073731005,0.01534044,-0.048660092,-0.03857252,0.099657595,0.03462785,-0.049392145,-0.020124042,0.009103984,0.06708242,0.12662426,-0.005641311,-0.050263785,-0.026837675,0.07329036,-0.051714167,-0.030391678,0.014129652,-0.022770016,0.007784704,-0.019411787,-0.014880369,0.108793885,0.0002830119,-0.06013856,-0.0052198297,0.0068894834,-0.054023154,0.014645911,0.023699021,0.03458185,-0.011130478,-0.06773823,-0.015411516,0.00087330415,-0.0032208976,-0.02238766,-0.02356522,0.002316595,-0.035772357,0.05646947,0.0009966408,0.015456045,0.039360076,-0.021654814,-0.07928342,0.12884128,-0.05251298,0.012085919,0.035147738,-0.024392834,-0.010602057,-0.04736284,-0.10640867,0.04491521,0.03907568,-0.090035304,0.022749333,0.003371932,-0.019033289,-0.11213758,0.04886661,-0.0057899724 +1.7.99.1,"A flavoprotein. Reduced pyocyanine, methylene blue and flavins act as donors for the reduction of hydroxylamine. May be identical to EC 1.7.2.1, nitrite reductase (NO-forming).",384,0.99999994,-0.088902116,-0.031816,-0.056494027,0.041544687,0.068511166,0.035604436,0.052224666,0.019950861,-0.0013136984,-0.10818977,0.013986027,-0.00084911386,-0.073930144,0.024033224,-0.07592817,0.0647227,-0.06316206,-0.041400023,-0.044319276,0.027148591,-0.0014017096,-0.011279292,0.07151462,0.061018676,0.0034860384,-0.0042031775,0.02445252,-0.032370597,-0.01334293,-0.075627156,0.064864844,0.02688646,0.06473999,-0.006678644,0.0036010372,0.024066797,-0.015549832,-0.048146486,-0.07144456,0.0023404902,0.050131213,-0.036817834,0.019989852,-0.009529595,0.038624335,0.05045498,0.015842734,0.07522122,-0.020381534,0.024619175,-0.0054945727,-0.04379456,-0.08891073,0.0797801,0.09230695,0.051579915,-0.082474254,-0.043281216,-0.018667731,0.03603485,0.04922242,0.030923495,0.008509148,-0.008273891,0.033907108,-0.029395653,0.04448002,-0.03168787,0.046947427,-0.058768548,0.036203157,-0.03552882,0.0018884485,0.08904027,0.019352404,0.055925984,0.016890014,0.0076049035,-0.021159468,-0.004839324,0.04105232,-0.031433936,-0.002827664,0.10489457,0.06366024,-0.058293726,-0.05650511,0.014394519,-0.03353036,0.04938275,0.003068128,0.054735925,0.07494396,0.02590076,-0.09314494,0.028080134,0.0066478387,0.018171998,-0.011876298,0.033895772,-0.026316945,0.008398281,-0.0095079085,-0.042113826,-0.081264324,0.011536058,0.032630138,0.012247708,0.019452473,-0.03508312,0.03355845,-0.074762814,-0.010097241,-0.025428839,-0.023728244,0.064066686,0.004077213,-0.0066216327,-0.09266934,0.022285292,-0.0019303735,0.04912795,0.062432334,0.02884978,-0.05285337,0.0354285,-0.16445161,2.4594659e-33,0.05412373,0.0012940012,0.006673833,-0.026892884,-0.004847209,0.030575281,-0.020270156,-0.010221137,0.06678718,-0.120639324,-0.07368419,0.0060411724,0.06828254,-0.038255133,-0.017149111,-0.088694856,-0.03523871,-0.010929591,0.074161336,-0.012705442,0.008948425,0.050522033,-0.08255982,-0.0053869863,-0.00609229,-0.05123345,-0.07524545,-0.0095935995,0.011882234,0.007545828,-0.010806038,-0.05077891,-0.053847246,0.016772678,0.0038997272,-0.0033058072,-0.09051453,-0.07804025,-0.073230036,0.06645625,-0.10107096,-0.00023328813,-0.053121768,0.0033914351,0.054088548,-0.020620124,-0.069962166,0.07931099,0.030006383,0.060082622,0.02573326,-0.05160703,0.07957963,-0.03357122,-0.034824222,0.05847581,-0.0063618645,0.0060358816,-0.00015020109,-0.0059968396,0.032990478,0.06663407,-0.031678174,-0.023391172,-0.04384346,0.020423343,0.00912664,-0.076164216,-0.025954364,-0.06772183,-0.012898265,0.017109876,0.09975312,0.017752124,0.08532776,-0.046422154,-0.06339196,-0.012892696,-0.01833321,0.013048948,-0.027229283,0.01041161,0.0452935,0.011898643,-0.036861196,0.026843894,0.03649575,-0.006325462,0.05787757,-0.031157212,0.024321312,-0.11292759,-0.040102974,-0.072134994,0.039795782,-1.2015699e-33,0.0019556023,-0.07594741,-0.047005642,0.034009203,0.042029653,-0.009299258,0.11035666,-0.06656914,0.012288692,0.013907275,0.105942614,-0.07279822,-0.029631592,-0.034309827,0.08127695,0.017480014,-0.048914295,0.039730072,0.01344011,0.03254902,-0.06948827,0.0076010977,0.012247847,0.06936667,-0.012401621,0.03327044,0.0091163395,-0.031774968,0.13031535,0.022694942,-0.119620964,0.026297279,-0.070517704,-0.07563712,0.029410522,0.06539195,-0.032033335,-0.0021902286,-0.010110371,0.0046377108,-0.006733031,0.040354054,0.036360368,0.042524308,0.013482736,0.112936355,-0.032939672,0.073938236,0.036149394,-0.027041411,0.009566895,0.067783244,0.009361635,0.11708386,0.035773404,-0.02642397,0.0702025,0.03453468,0.025775922,0.01830586,-0.044328988,-0.14156164,0.030701082,-0.0010708048,0.048021287,0.016958944,0.046236936,0.14904475,0.008965605,-0.04440622,0.08864668,-0.06620167,0.10849346,0.048643265,0.004223229,-0.07442087,-0.013113111,0.0022316033,-0.051845986,-0.05155007,0.08353813,-0.013681362,0.0066715116,-0.046632983,0.025237622,-0.06813381,0.030042764,0.002478799,-0.015619513,0.037699904,0.012168556,0.027125632,-0.029545529,0.03272692,0.009546688,-3.3341305e-08,0.040563613,-0.06770854,-0.0005933073,0.023250712,0.12155472,-0.010797944,-0.042446993,0.03464178,0.039235406,-0.010581413,0.015836464,0.081541985,0.042086378,-0.03166853,-0.013678634,-0.03272905,-0.01568053,0.005975629,-0.02758786,0.02231969,-0.0578737,-0.002294838,-0.16214663,0.019916678,-0.05364485,0.015702112,0.014110872,0.002028739,0.07904123,-0.10986709,0.07827745,0.079801075,0.060802367,-0.024325365,-0.096625045,-0.005815306,0.038336013,0.012075679,-0.051370062,0.045174386,-0.13568944,-0.015689438,-0.020413041,0.0078536095,0.10013918,-0.063774794,-0.0072307964,0.009775455,-0.016847724,0.0031444125,0.01706634,-0.03038595,0.011081835,-0.03476619,-0.059385452,-0.02988718,0.027572598,0.024334,-0.0005571319,-0.07007156,-0.029913481,-0.0071014212,0.14610322,0.06322672 +1.7.99.4,"The Pseudomonas enzyme is a cytochrome, but the enzyme from Micrococcus halodenitrificans is an iron protein containing molybdenum. Reduced benzyl viologen and other dyes bring about the reduction of nitrate.",384,1.0,-0.04361507,-0.026976224,-0.08793006,0.0123273125,0.09314056,0.018973326,-0.05572011,0.01855881,-0.005519997,-0.048275508,0.0260091,-0.035871837,-0.0016067703,0.059416506,-0.12413624,0.006895826,-0.03145404,-0.022639435,0.023743408,0.0723495,0.0051484364,0.043494977,-0.06841334,0.0025130974,0.020691311,0.042266227,0.042490065,-0.023361923,-0.067933336,0.01588365,-0.053866845,-0.023932327,0.124774925,-0.09670137,0.1158172,0.015296011,0.027247017,-0.0011350664,0.08260336,0.00567707,-0.01042293,0.03838238,0.0037217499,-0.06226296,0.019186398,0.004788954,0.040203482,-0.026277456,0.056170113,-0.03307716,-0.071975395,-0.052051574,-0.052564412,0.05364122,0.01059945,0.036525067,-0.0470829,-0.06623948,-0.016471203,0.002093272,0.002302182,-0.025731755,-0.015185786,0.02368616,0.0653774,0.0005225817,0.032192327,-0.047162656,0.03605102,-0.10272317,-0.04875495,-0.018569928,0.03259863,0.029194742,0.012360921,0.033955097,0.02153497,-0.029746989,0.06105855,-0.003939141,-0.026854252,-0.022826197,-0.020976106,0.098861896,0.019290816,-0.041301537,0.023339927,-0.023550507,-0.032194644,0.0025583406,-0.0050958935,0.030491162,-0.029604694,-0.08268236,-0.055833343,-0.0010119417,0.013319759,0.06634336,0.02924069,-0.032322593,0.02040109,0.01725909,0.024654321,-0.14167504,-0.06773095,0.0065529095,0.040663783,0.09980233,0.07050959,0.007175386,-0.0036623832,0.0091422545,-0.016550144,-0.07646888,0.031085594,0.03821571,0.124032155,-0.051257122,-0.10792688,0.10506724,0.020128185,-0.01585334,0.02134627,0.026596166,-0.024933062,0.034124628,-0.105529815,3.253652e-33,0.05393577,0.05349689,0.048367787,-0.03942493,0.02783432,0.026656725,-0.08228388,-0.04439733,-0.011224608,-0.0863719,-0.020584878,-0.0032608088,0.021512963,-0.02559219,0.0031240534,0.025590703,-0.0108268615,-0.06121231,0.061017513,0.06051484,0.025539683,0.09414033,-0.015343077,-0.011921617,0.08208359,0.017740697,-0.034687307,-0.03933323,-0.007950121,0.017145015,-0.0028457209,-0.043243185,-0.10569581,-0.028453534,0.0886759,-0.020358533,0.0015185509,-0.046550456,-0.05577731,0.024603281,-0.036018737,0.03995471,-0.059180662,0.0045414995,0.06931505,-0.057406224,-0.10942548,0.123287804,-0.00023538673,0.07110955,0.0010523879,-0.051830612,0.037347686,-0.06273657,-0.05292819,0.040515482,0.0136537645,0.042835332,-0.014607703,0.049422313,0.017405784,0.063358925,-0.011295374,0.094186656,0.035336476,-0.053283494,-0.043770816,0.025712783,0.03039571,0.060253944,-0.13727981,0.0792436,0.058431298,0.04706203,-0.022491323,-0.10657227,-0.031905603,-0.05486672,0.05359078,0.009068661,0.026821623,-0.033180464,0.028030911,-0.09987769,-0.09980781,0.037992384,0.010217533,0.02788363,-0.025041467,-0.04614194,0.05084111,-0.09553866,-0.058791175,-0.014948343,-0.055963818,-4.9754576e-33,0.09675961,-0.095127046,0.024638074,-0.0048330287,-0.051922224,0.056846365,0.014258679,0.015048861,0.0037929835,-0.0045315395,0.09260778,-0.012969865,0.0008368311,0.01036391,0.005006666,0.075284846,0.015761472,0.013380975,0.021769954,-0.023945859,-0.010682578,0.007827487,0.015137127,-0.02345015,0.010369649,0.058783595,-0.08418803,0.06444828,0.06229823,0.08334906,-0.039122857,0.07435318,-0.03771136,-0.16514425,0.005723492,0.019866556,-0.019702781,-0.008195644,0.05372949,0.020819867,0.033329964,0.009104118,0.013317015,0.078945585,-0.05263842,0.04681169,-0.091880195,0.009184992,0.035859205,-0.047203667,-0.0033780136,-0.049890734,-0.04270045,0.079076685,0.0074706487,-0.0035302474,0.023400096,0.061484292,-0.039345887,0.036731075,-0.05605383,-0.08142193,-0.0099465195,0.0076621003,0.052801844,0.06518296,0.03164266,0.04218255,0.014513161,-0.06016109,0.051553518,0.04338544,0.057239,0.0078031514,-0.04765477,0.012097608,-0.003465466,0.0248912,-0.0259839,0.023587268,0.081266664,0.009423898,-0.03738946,-0.04959663,0.028285554,-0.0445884,-0.006710449,0.09893777,-0.067851394,-0.034905355,-0.012346093,0.016068252,0.033773277,-0.048583828,-0.046052,-3.4958845e-08,0.053435285,-0.037907667,0.050430343,-0.026548177,0.0064786407,0.0708005,-0.0015796949,-0.03113942,0.019975614,0.0012097456,0.010272734,0.05985277,-0.05834913,-0.04265503,0.04125824,0.033824924,-0.08375289,-0.043769635,-0.010479146,0.026711894,-0.094945095,-0.016286006,-0.13117635,0.066117674,-0.018560952,-0.049917497,0.074271955,0.006850018,-0.02176381,0.008234668,-0.07028403,0.008712815,0.0025667814,-0.022378951,-0.13936713,-0.0373743,0.008956875,-0.03266415,-0.068390094,-0.0251297,0.021030998,0.0005858906,-0.13174935,-0.029421153,0.04383894,-0.04311062,0.024021508,0.05488707,-0.0023087033,-0.009443641,-0.0012065338,-0.030692862,0.0101848105,-0.00167214,-0.09040472,0.048703235,0.07320297,-0.029241487,-0.060387604,-0.012366124,-0.02654596,-0.040709347,0.14105922,0.03687581 +1.7.99.6,A copper protein. Reduced viologens or methylene blue act as donors for the reduction of nitrous oxide.,384,1.0,-0.07381403,-0.0056936513,0.0026358627,0.03732505,0.10231726,0.033738688,0.071401075,0.066329055,-0.024734793,-0.07039452,0.020342177,-0.020435227,-0.043450147,-0.049711738,-0.10219289,0.037848182,0.058957662,-0.0109206345,-0.020036513,0.013952952,0.05152656,0.018594423,0.0036635445,-0.04216079,-0.09131298,0.0961948,-0.02953128,-0.021200104,0.073542364,-0.019206122,-0.026656944,0.015543762,-0.014383863,-0.01764976,0.010315655,-0.03196759,-0.031720635,0.0014893454,-0.0743841,-0.018967949,0.08105833,0.024857916,0.06333039,0.0075373133,0.029314684,-0.0011307906,0.073414735,0.042819,0.021083124,-0.06161708,0.016257929,-0.03812501,-0.02103029,0.06854324,0.055161178,0.026170237,-0.10862162,-0.14243641,-0.007428911,-0.017498728,0.07265189,0.002332352,0.012827486,0.032740343,0.1552428,-0.008748913,0.02663545,-0.0068952744,-0.017684251,-0.028552303,0.0010410296,-0.018654667,0.0035596301,0.0210069,0.014233957,0.09561567,0.12139113,-0.07439328,0.05516408,-0.029731145,-0.014365659,0.07589027,0.017111378,0.04735398,0.0760237,0.06539687,0.011649563,-0.01730207,-0.07826644,-0.0357215,0.013002259,0.07487711,0.030487707,-0.03501341,-0.06519234,0.031228296,-0.024748318,-0.05422141,0.0037748322,0.038277753,0.0188205,0.06854133,-0.04097679,-0.11729978,-0.110812455,0.038908407,-0.04186306,0.052546572,0.048742693,0.060763367,0.0073270723,0.00032448414,-0.032920748,-0.024820575,0.0067029833,0.051610027,-0.003744497,-0.028052814,-0.07423629,-0.02720524,-0.00032164413,-0.013161438,-0.037080925,-0.02507288,-0.10077847,0.0008680135,-0.040049862,-7.465844e-34,0.020878267,-0.0018509069,0.01843491,-0.0052097077,0.0864487,0.036176033,-0.081543006,-0.027314141,0.022723662,-0.008812285,-0.025278969,-0.043779865,0.057571128,0.01097405,-0.034014814,-0.063425116,-0.043167673,0.036234837,0.074635394,-0.05574625,-0.015703004,0.13400224,-0.017776974,0.009209808,0.034472518,-0.050476093,-0.10161953,-0.053511858,0.017567573,-0.049989205,0.0075412705,0.054670926,-0.034699995,-0.04464389,0.070253566,-0.049218938,0.0443424,-0.051708903,0.00095451484,0.07275686,-0.0053355866,0.05360099,-0.09493596,0.05401542,0.047168147,-0.08954392,-0.06297433,0.039293557,-0.0059671085,-0.02244317,0.008613685,-0.046864085,0.06326129,-0.09872365,-0.055232037,-0.0027370537,-0.02472249,0.014326775,0.0200648,-0.04208506,0.007809857,0.0065940493,-0.031616367,0.027584966,-0.025054563,-0.009737716,-0.021655962,-0.05401388,0.008883101,-0.040570773,-0.10825085,0.021305723,0.029814169,-0.06596832,0.054458734,-0.08189555,-0.05684387,-0.038420253,0.033241913,0.033725575,-0.043642856,0.037048217,0.027946899,-0.048757937,-0.0065877517,-0.05439498,-0.059498526,0.024111953,0.09955611,-0.1056958,0.07921209,-0.05643707,-0.076977864,-0.08541908,-0.049131893,-7.737052e-34,-0.016631948,-0.051497787,-0.03808293,0.024811385,0.044757515,-0.03223259,0.038104266,-0.015542739,0.03912497,-0.046858843,0.139894,-0.01493562,0.06765983,-0.05046698,0.034333583,0.057766646,-0.0967729,0.09060725,-0.015700331,-0.00031242764,-0.0963781,0.044884976,0.03409658,0.014564369,-0.040355463,0.064530954,-0.07817007,-0.004529872,0.11317354,0.057404,-0.0016161016,0.0728611,-0.101567805,-0.028162733,0.034527276,0.052266728,0.038752727,-0.016690154,-0.016475175,0.03154545,0.046525113,0.053636562,0.031011619,0.08226251,-0.034948774,0.050676357,-0.07945475,-0.036744036,-0.08421859,0.019597227,0.09851253,0.021388182,-0.023616815,0.058442026,0.035949267,0.00537647,0.022291176,0.008657168,0.013512607,0.07256879,-0.008322188,-0.022627043,-0.005889349,0.023487017,0.0072436123,0.04689289,0.013493956,0.1391149,0.044930305,-0.0718428,0.0708092,0.10211848,0.067186706,-0.01870552,0.017769244,-0.035877317,0.01642561,-0.036922745,-0.061990753,0.028593952,-0.057859797,0.038253628,0.004785128,-0.06844715,-0.024218043,0.021043705,-0.004780051,0.08530688,0.007663963,-0.03185362,-0.03405785,-0.12046086,-0.027653655,0.10476027,0.001350644,-2.3558922e-08,0.014246683,-0.030471422,0.08176431,-0.025563909,-0.020830767,0.025310554,0.044678044,0.0030920075,0.051454134,0.02122522,0.028572159,0.03815084,0.010640259,-0.0865342,0.03905019,0.029549027,-0.030308796,-0.03667769,-0.02656044,-0.0004556037,-0.021456359,0.021706475,-0.03573716,0.010515635,-0.010303687,-0.016336463,0.06481026,0.012262082,-0.08732853,-0.0144086685,0.0073637334,0.06363989,-0.029596318,0.010439731,-0.060820557,0.009013712,0.04586846,0.019117674,-0.03285054,-0.009237736,-0.058727242,-0.044486348,-0.053964294,-0.019734824,0.021190587,-0.026374469,-0.053956002,0.08303662,0.035434626,-0.024367722,-0.047010146,-0.011040174,-0.029152166,-0.038972076,-0.08818876,-0.03411656,0.009875457,0.047356736,-0.032837093,-0.074478105,-0.012233837,-0.032585472,0.11522431,0.008605883 +1.7.99.7,A heterodimer of cytochromes b and c. Phenazine methosulfate can act as acceptor.,384,1.0,-0.082203686,-0.026157167,-0.06036757,-0.048054773,-0.030532163,0.011323341,-0.009135714,0.039197534,0.0063514435,0.026797846,0.013196613,-0.0026434967,0.003897688,0.042640805,-0.01803564,0.068554826,-0.0774276,0.0033382243,-0.02368432,0.097079426,0.0015298522,0.02300961,0.009500836,-0.01600269,-0.077143185,0.07508288,0.0066773635,0.070915654,0.004523092,-0.071391635,2.1676693e-05,0.051877234,0.017722666,0.019061117,-0.038846232,-0.0025866597,-0.050233897,0.00795542,-0.0077853887,-0.046784006,0.010855307,0.07609527,-0.03767589,0.02661606,-0.046260506,-0.10884915,-0.020916011,0.027619954,-0.00017906449,-0.072647244,-0.04369766,-0.01224087,-0.06263374,0.11592987,-0.04290208,0.05843151,-0.11722988,-0.0016156189,0.036422927,-0.04061735,-0.08173992,-0.001646567,-0.02864368,-0.04541067,0.034178726,-0.03610023,-0.0135764545,-0.0272121,0.06384086,-0.032593735,-0.03691637,-0.051661402,-0.009399421,-0.03825444,0.006116072,0.07817344,-0.018466014,0.006545412,-0.010095453,-0.029829528,-0.07151715,-0.07765888,-0.0031947973,0.0633746,0.07776878,-0.03753961,-0.06243387,0.030179294,0.027092643,0.0043765884,-0.031032247,0.017475635,0.011771557,-0.032482725,-0.08018867,-0.046518527,0.11036744,0.13581935,0.02426887,-0.0072989934,0.075433955,0.09043214,-0.0755964,-0.05754663,-0.072725125,-0.065747224,0.08265701,0.090234056,-0.024483928,-0.07304882,-0.024025213,-0.08446353,0.07381114,-0.009636588,-0.033872858,0.093728036,0.059456494,-0.11169254,-0.019703371,-0.076200135,-0.04328672,0.025255218,0.016798083,-0.10325807,0.041481245,0.024904126,-0.039182033,1.1758931e-35,0.016933735,0.09107844,0.018903008,0.042022634,-0.072987676,0.034447983,-0.08303346,0.045429792,-0.032238357,-0.068426274,-0.08799746,0.027078198,-0.005095684,0.02602188,-0.018673254,0.053122684,0.04695193,0.030885825,0.09497363,-0.0922408,0.033355415,0.050827656,-0.06588361,-0.044664104,-0.015024282,0.016987756,-0.045456856,0.050837032,-0.027705373,0.003329226,0.09799345,-0.062145207,-0.047749832,0.03756671,0.0019500137,0.08783417,-0.089867845,0.04591051,-0.018446682,-0.03151363,-0.063883066,-0.062115755,-0.013235875,0.054289635,0.039180666,0.010960311,-0.12615415,-0.032394446,0.0042228466,0.06352899,0.03689399,-0.08093741,0.06763981,0.049686637,-0.082368426,0.08422926,0.046226796,-0.0381395,0.003493707,0.029107837,0.06879425,0.097346775,-0.095797494,0.08477409,0.038882133,0.002670079,-0.0238637,0.013286373,-0.063721955,0.1143081,-0.032521322,-0.036456034,0.067135274,0.09342025,0.047326226,0.041513648,0.0006472033,-0.03263952,0.030548034,0.079526566,0.014969739,-0.051311705,-0.031941585,0.028264832,-0.12202449,-0.019751403,0.048873764,-0.058986973,-0.016596928,0.03962979,0.05803917,-0.11373987,-0.04536233,-0.041830737,0.020964958,-2.9472509e-33,0.102941655,0.004495106,0.02535423,-0.052609213,-0.02014771,0.066496104,0.040917374,-0.09177224,0.029941583,-0.06513193,0.07721296,0.01816203,0.01767735,-0.0037780295,-0.017053429,-0.022330953,0.0337654,0.015218365,0.014010625,0.034952156,-0.02546802,0.03224086,-0.03601792,0.02226254,2.1420337e-05,-0.0050752605,0.074926294,0.010323622,0.056036275,0.059147984,-0.0008889058,0.027748808,-0.015940886,-0.09358332,0.040860116,0.049560636,-0.055978525,-0.020192511,-0.01286386,-0.010032646,-0.028565569,-0.014048861,-0.0079334285,0.08143355,0.1068985,0.040474802,-0.014631181,-0.005467668,-0.040918607,-0.005323789,0.018505681,0.07996374,-0.023586458,-0.009406268,0.11392778,0.071394145,-0.050567806,-0.094205014,0.026964337,-0.051412888,0.018944476,-0.099955864,-0.032938503,-0.016415501,-0.059990544,0.0047892747,-0.019426864,0.028793203,0.03021482,-0.003834592,0.010146613,-0.01672157,0.043317102,0.03886456,-0.033032093,-0.011585205,-0.009687198,-0.006853674,-0.016613754,-0.010196187,-0.00085628184,0.027434742,0.09610572,-0.070676565,0.014856697,-0.045315098,-0.05212565,0.020191683,0.0046409788,-0.03968421,0.034775604,0.0035970465,0.006884678,0.0052764146,-0.016055714,-2.722101e-08,0.054255795,-0.029761588,0.0427012,-0.016782487,-0.035936244,0.0040031103,-0.011218194,-0.05067026,0.010118374,0.0773478,0.0258876,0.06584742,0.004629923,-0.02593377,0.027573623,0.027986517,-0.055565745,-0.056434624,-0.039025858,0.023072535,-0.09442933,0.0033811748,-0.0627897,-0.015268798,0.07347625,-0.07495458,-0.04621139,-0.0744802,-0.02239887,0.037395246,0.09626477,0.03593749,0.05014534,-0.018194225,0.034346793,-0.03261733,0.049425323,-0.0423656,-0.045175843,-0.023829112,0.06910781,-0.035655312,-0.09434292,0.043793306,0.020321785,0.014703747,0.02864709,0.04337806,-0.01929799,0.006436923,0.010452166,0.008127151,0.061549786,-0.043775726,-0.09029494,-0.023927767,-0.0066403365,-0.010431687,-0.05253685,-0.082694516,0.071010545,-0.0047659413,0.057661574,0.032596637 +1.7.99.8,The enzyme is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria. The conversion of hydroxylamine by the enzyme from Brocadia anammoxidans results in the formation of NO and N2O [1]. Hydroxylamine is not a substrate for the enzyme from planctomycete KSU-1 [2]. ,384,0.99999994,-0.018686915,0.010737484,-0.038572155,-0.038707152,-2.2020766e-05,0.051140264,-0.019578142,-0.032769985,-0.035259336,0.0037404306,-0.023561804,-0.0644636,0.004859245,0.010116492,-0.09665352,0.10488923,-0.071506545,-0.093131766,0.027168835,0.034962576,0.08723076,0.00781544,-0.009052711,0.011607081,0.0705052,-0.0021507186,0.026168909,0.0067921146,-0.06293892,-0.05120635,0.040273566,0.05719682,0.06787557,-0.032114226,0.107964344,0.059604824,-0.015049752,-0.04049497,0.03589127,0.026819393,0.030963657,0.019606942,-0.019497724,-0.008206889,0.0295499,0.018066099,0.06818663,-0.0037343174,0.051083427,-0.004467947,-0.082342565,-0.0552041,-0.016775483,-0.018318223,0.061193638,0.041763738,-0.029932667,-0.047343854,-0.062638395,0.04580047,0.004587073,-0.008165034,-0.023646774,-0.009189546,-0.0063748546,-0.117684916,0.013197813,-0.06775005,0.011973178,-0.06780458,-0.057044666,-0.100982524,0.018318217,-0.01661445,-0.036405224,-0.040967297,0.040377647,-0.06365577,0.040370494,-0.022461494,-0.050457444,0.010094434,0.012899005,0.080405995,0.044859257,-0.040903434,0.03861477,-0.0024293053,0.065597855,0.01904135,-0.0536124,0.010362117,0.021805204,-0.02759425,0.004748843,0.0039014877,0.0085360035,0.0707458,0.013224715,-0.0054702945,0.051397126,0.066530906,-0.05399222,-0.109723225,-0.02906399,0.03444966,0.083269656,0.120481946,0.042858277,0.01883001,-0.008464389,-0.027544044,0.063322715,0.032902777,0.02306259,0.069261104,0.078721315,-0.07227336,-0.09898648,-0.006127834,-0.017932283,-0.079446286,0.05155589,0.0006148347,-0.047508318,0.09179472,-0.06861066,3.7179953e-33,0.0776885,-0.0046928716,-0.024127603,-0.013580286,-0.039607313,0.010475763,-0.09286506,-0.050203595,0.060196664,-0.11132442,-0.05457963,-0.015637679,0.02803294,0.027968492,-0.060409423,-0.043877177,-0.037554827,-0.011564384,0.047941618,0.07569465,-0.030989194,0.0037135268,-0.053513102,-0.03887733,-0.038827986,0.019969642,-0.003860912,-0.049041502,0.029725946,-0.006064162,0.093959436,-0.061483603,-0.097302124,0.027857635,-0.02042925,0.015280961,-0.031154864,0.024160368,-0.06219946,0.061949313,-0.08751132,0.07102616,0.028573798,-0.07732848,0.018603446,-3.1380965e-05,-0.04968466,0.09384915,0.115729354,0.038998604,0.022885673,-0.009700254,0.11048337,-0.0861088,0.03963683,0.0704066,0.04037082,0.061062835,0.104111865,0.037392054,-0.062375233,0.012273862,-0.045742523,0.05443915,0.023932328,-0.0006734017,0.018068936,-0.007018813,0.014169072,0.015351018,-0.11229358,0.012335719,0.07825283,0.07968721,-0.016042968,-0.056847125,-0.048617985,-0.0038534584,-0.019891493,-0.017117893,0.107082985,-0.00027904514,0.07615755,-0.078138985,0.012590233,-0.008329769,0.014326884,0.028906735,0.017494855,0.025852451,0.09153664,-0.07982516,-0.05789737,-0.011553445,-0.0014054547,-3.9982526e-33,0.09546339,-0.07335637,0.0068752114,-0.10442546,-0.02189841,0.048201907,0.032961704,0.035834927,0.021169102,-0.008551997,0.08193805,0.016254013,0.040625542,-0.012516637,0.057453565,-0.09187692,0.010207361,0.058272384,-0.022968862,0.0039089657,-0.01019469,0.09436658,-0.06125976,0.0067256396,0.0003264806,0.041541025,-0.058367163,0.07263035,0.0671692,0.009685596,-0.059271947,-0.023180988,-0.026800375,-0.05102432,0.05025883,0.06083847,-0.072365314,-0.0020350504,-0.021790672,0.038699184,0.0086755,0.045521405,0.01315217,-0.0003498877,-0.03146235,0.023348209,-0.105553664,-0.027879663,-0.01964442,-0.056710485,0.0002219396,-0.01310824,-0.0046447823,-0.020053258,0.049247004,0.01616272,-0.021386774,0.03797458,0.018179798,-0.027715044,-0.0414349,-0.03433204,0.06121924,-0.038306817,-0.013667304,0.08447434,-0.06399974,0.067138866,-0.030858163,-0.005106322,-0.009402922,0.018099269,0.030390067,0.03949812,0.016267002,-0.06296053,-0.1006429,-0.010037283,-0.017998062,0.007819131,0.050265256,0.023202773,-0.011987556,-0.037068285,-0.0066565834,-0.04688995,0.031705882,0.028781759,-0.040249903,-0.019452598,0.052875876,-0.03889256,-0.06505666,0.047748733,0.044705153,-3.4078898e-08,-0.018652292,-0.054197606,0.14204375,-0.01507418,-0.0055520567,0.029921984,0.017786179,-0.0010407706,0.09884009,-0.015693627,0.063757256,0.1151982,0.038689185,-0.027102511,-0.052490104,-0.014775066,-0.03662953,-0.02813858,-0.026671449,0.028177464,-0.06891666,-0.025768394,-0.112859026,0.0885719,0.022111868,-0.019973004,-0.002033822,0.029813815,-0.0022757612,-0.058469977,-0.055570535,0.027808178,0.023062117,-0.026497032,-0.14714053,-0.025675982,0.02807379,-0.030933687,0.023329625,-0.04622892,0.032258976,-0.083513886,-0.031235728,-0.03938335,0.049496118,0.0381674,-0.012959131,-0.015653437,-0.0753818,-0.039697103,0.04313794,-0.045510344,0.019358128,-0.0415596,-0.08873049,0.024484847,0.0014526208,-0.027799116,-0.0061450284,-0.012822791,-0.035964336,0.026858525,0.21025802,-0.053392526 +1.13.11.56,This enzyme is involved in naphthalene degradation. Requires Fe2+.,384,0.99999994,0.0036899906,0.031039324,-0.07904894,0.060710203,0.09181862,-0.0022521075,-0.04404542,0.013006588,0.0013807586,-0.10595309,-0.065540105,0.0078072413,-0.039629165,0.0627516,-0.0295626,0.012210153,-0.039575294,0.009012766,-0.015190967,-0.009150498,0.0624744,0.04482128,0.04991911,-0.052292246,-0.013617736,-0.0018428559,0.054966945,-0.060596105,0.0054261917,-0.07194285,0.007578293,0.00047384578,0.0017370331,-0.055003908,-0.030274749,0.08880426,-0.064979255,0.002037492,-0.013566086,0.014848141,0.012564934,-0.053061925,-0.079674564,-0.07184659,-0.02524638,-0.05046742,-0.018244203,-0.028985152,0.04483982,0.07583267,-0.09366376,-0.021490835,-0.038512398,0.044169165,0.039034612,-0.048178297,-0.024783587,0.006108417,-0.08384627,0.0077495724,0.044512127,-0.021793265,-0.020627184,0.0016305085,0.034918092,-0.040955026,0.06597037,-0.05958438,0.011246931,-0.011318026,-0.05399572,-0.05144013,-0.00030034466,0.0071887365,0.0057777218,-0.0033481221,0.045893192,-0.089899406,0.11128788,-0.021663278,0.03658147,-0.0020144153,0.0103805885,0.088088565,0.06859715,0.084297396,-0.05509059,-0.04334985,-0.07167617,0.06595033,0.008556404,0.054231536,-0.025563395,0.030086378,0.0030532759,-0.010514891,-0.011659275,0.046237916,-0.037836064,-0.002919367,-0.0750307,0.065312944,-0.057283398,-0.066568695,-0.08534352,-0.026891313,-0.004087229,0.056707684,0.01912933,-0.014436925,0.06515642,0.04647689,0.074690945,0.0010428285,0.011000207,0.10235194,0.006817915,-0.056871414,-0.06664427,0.041806053,0.038141824,-0.019101249,-0.01125822,0.038873564,-0.07837763,-0.0060428977,-0.10033722,-3.2905581e-34,0.039948132,0.08150401,0.0064679664,0.00414492,-0.046760537,-0.021664552,-0.082945034,-0.056340717,-0.030811358,-0.053469155,-0.034851458,-0.097911395,0.0024454934,-0.018918058,-0.0022185808,-0.07421598,-0.0040602125,0.020229788,0.08029306,-0.04013418,0.029846732,0.04590796,-0.025654273,-0.040647145,0.025542993,0.091973014,0.020908408,0.043843277,-0.05456974,-0.019992435,0.09360386,-0.04715037,-0.12286098,0.002035041,0.079384245,-0.004273307,-0.012282076,0.00042460952,-0.05221828,-0.0033329036,-0.05228542,0.06955727,-0.03159293,-0.047958653,0.03400673,-0.10846789,-0.05621338,0.19594353,0.08031894,0.09423846,0.03862967,-0.026455805,0.07517734,-0.030603433,-0.06324298,0.016340358,0.0004731942,-0.05868672,0.04590916,0.08887869,-0.0054306714,-0.0065263966,0.0143083725,0.025369568,0.036673073,-0.020491473,-0.09045622,0.04976845,0.008230139,0.106760934,-0.02208509,0.028966624,0.11751098,0.003430783,0.04387962,-0.056882467,-0.07933757,0.01205398,0.09486447,0.026612224,0.04201674,-0.060901504,0.010525929,-0.030440057,-0.070383236,-0.033929054,-0.037537195,-0.021634903,0.0027544529,0.060974516,0.012635219,-0.055770073,-0.071014866,-0.0018764668,0.017043771,-9.408484e-34,0.06626189,-0.04761205,-0.023702566,-0.043742284,-0.025087884,0.049792238,0.04139785,-0.049628053,0.006858586,0.039737005,0.07313501,0.013011104,0.04497399,-0.06733064,0.0036411686,0.04107467,-0.05871775,-0.017955428,0.01156848,-0.016756238,-0.034505438,0.10405004,-0.06337464,0.09863625,0.0055481237,0.03621933,-0.074113406,0.062107287,0.074009076,0.03494936,0.0405398,-0.030538924,-0.068764836,-0.020755522,-0.0074900533,0.006728663,0.028962664,0.0064528952,0.007992515,-0.028528882,0.01324302,0.010203388,0.0021985339,0.0713047,0.04052437,0.044114087,-0.014622734,-0.013779318,0.007601271,-0.03383392,0.02281747,0.018398808,-0.084197655,0.0035987147,-0.0124002425,0.04616382,0.063577875,-0.017038705,-0.016637458,0.018816005,0.0011934921,-0.021196706,0.060792826,-0.012318171,0.0069920765,0.005246247,0.007730363,0.1017576,0.07059056,0.03280501,0.07210757,0.049030043,0.062472492,-0.008465696,-0.06690345,-0.06763739,-0.017097289,0.0369229,0.011409557,-0.009360756,0.031181859,0.012118403,-0.025470445,-0.09381713,0.018607251,-0.06717904,0.015705636,0.058479767,-0.00037028134,0.0009280089,-0.045621876,-0.02907755,-0.09756434,0.012907464,-0.014441703,-1.9848835e-08,-0.021636419,-0.08493192,0.04801645,-0.05652953,-0.04863067,-0.01196241,0.05341026,0.009877389,-0.019577866,-0.015676787,-0.034724236,0.1269787,0.033878215,-0.026017444,0.045057666,-0.051999133,-0.0051774005,0.08396599,-0.02696727,-0.06908149,-0.11054094,0.007694071,-0.12997329,0.0276934,0.01913394,-0.05577741,0.020623043,0.03588614,0.07635323,-0.05256043,-0.04389503,0.055616032,0.008748933,-0.048213817,-0.06728055,0.03115632,0.0007574341,-0.025414202,-0.039007418,0.06275234,-0.03810418,0.037011124,-0.019528963,-0.0046782056,0.026743172,-0.00952013,-0.0022172215,-0.04171638,-0.0069098007,0.007379142,0.08045574,-0.013563792,0.0013746929,-0.027573446,-0.09022796,0.07960343,-0.022791944,-0.050034486,0.09034605,-0.0554647,0.0551459,-0.0053026504,0.20164965,-0.03845628 +1.8.1.2,"Contains siroheme, [4Fe-4S] cluster, FAD and FMN. The enzyme, which catalyses the six-electron reduction of sulfite to sulfide, is involved in sulfate assimilation in bacteria and yeast. Different from EC 1.8.1.22, dissimilatory sulfite reductase system, which is involved in prokaryotic sulfur-based energy metabolism. cf. EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin).",384,1.0,-0.027001053,-0.026906505,-0.08327875,-0.0034592517,0.048985235,0.05165533,-0.049721528,0.03204579,0.024793738,-0.059281725,-0.016734248,-0.002555914,-0.07582366,-0.0072434815,-0.108599745,0.019214874,-0.065452345,0.049255803,-0.03678873,-0.09579375,0.03597996,0.005567323,0.007697168,-0.045579705,0.043777753,0.040934324,0.017607626,-0.030607585,-0.090057775,-0.07591501,0.033056322,-0.011613159,0.07113756,-0.04130754,-0.013842907,0.12784447,0.051364303,-0.051967442,0.04610005,-0.031027235,-0.04260219,0.024811443,7.9299825e-05,-0.0915273,0.01154722,0.0064807604,-0.024150841,0.032197315,0.050477773,-0.09370409,-0.017894594,-0.023830414,-0.048392568,0.09753082,0.05293629,0.019019082,-0.020578656,-0.051923677,0.016040314,-0.018377973,-0.013371802,0.021616144,0.0066044675,0.003946263,0.054531924,-0.017773774,0.05774753,-0.0750664,-0.021238083,-0.022206634,-0.07402208,-0.031514153,-0.008011615,0.03024232,-0.0050716363,0.08941177,0.031743813,-0.07807575,0.08493774,-0.020442076,0.024139531,0.009371933,0.05753536,0.06666244,0.0074545434,-0.07787002,-0.0021524427,-0.070439994,0.015397101,0.004592387,-0.0123696895,-0.008387109,0.0019725973,-0.03884047,-0.05120818,0.053985734,-0.012892065,0.13328391,0.045096498,-0.027062923,0.024475044,0.069111824,-0.069528125,-0.08922719,-0.032657027,0.006483904,0.036870077,0.17936324,0.012745517,0.025215972,-0.003754792,0.0028437867,0.00045400218,-0.018836198,-0.051916666,0.088281885,0.07621339,-0.046343748,-0.09236979,0.033163972,-0.021679724,0.051188145,0.03681582,0.065727815,0.018355312,-0.05494202,-0.19304408,1.8164793e-33,0.077289715,0.047525007,0.058152802,-0.07753176,-0.0052913283,-0.030201912,-0.09692781,0.025177496,0.0206315,-0.027442992,-0.050901726,-0.010823908,0.018476145,-0.033975206,-0.02999565,-0.047234572,0.011835297,0.00020454875,0.05277322,-0.06489747,0.04786908,0.028665457,0.009673119,-0.019343678,0.044601843,0.020453636,0.01949152,0.035274517,-0.02139872,-0.0076155597,0.010909264,-0.09883357,-0.051810265,0.030642383,0.04660551,-0.051103815,-0.029424617,-0.02063539,-0.021547347,0.042014815,0.005523474,0.04153431,0.015593963,-0.0659162,0.06366731,-0.07511574,-0.06421196,0.040007755,0.11261122,0.088738956,-0.019334799,-0.0670218,0.103498474,0.0011460852,0.0134460665,-0.011396651,-0.0014207411,0.020720733,0.047176905,0.058814112,-0.0017873804,0.04684179,-0.038377035,0.00029749758,0.023820158,0.016970774,0.0026380091,-0.013344858,-0.02043974,0.11306177,-0.10113747,0.018774644,0.059112206,0.019593721,0.031318005,-0.06377579,-0.010459928,-0.037415065,0.01070016,-0.0044176998,-0.031047815,-0.06598165,-0.057387203,-0.0037757352,-0.070676014,-0.030062443,-0.03206482,-0.01735587,0.0046419767,-0.004110072,0.010900472,-0.07980665,-0.1123691,0.022899227,-0.020446403,-3.4499606e-33,0.0597654,-0.020290384,0.035478126,-0.09226711,-0.05552263,0.06595035,0.07649204,0.029417047,0.017596887,0.008676515,0.04354817,-0.021759853,0.067724384,-0.08348582,-0.013561635,0.046686657,0.0019152843,-0.0025631697,0.024303589,0.05390772,-0.04954385,0.10725534,0.023696642,0.03443001,0.06689062,-0.0033972098,0.034595106,0.039759725,0.06395204,0.032318946,-0.010066066,0.011340573,-0.050972607,-0.04289486,-0.059550174,0.03574557,-0.04953158,0.042681452,-0.0017436149,0.0018232862,0.014549339,0.0055052903,-0.021708155,0.08953374,0.043330457,0.059784353,-0.0887948,0.0725399,0.044105012,-0.03734031,0.052437443,-0.041209415,0.017683243,0.032748993,0.028281298,-0.02301728,0.025392871,0.022060841,-0.041313116,0.012266226,-0.03260372,-0.11274313,0.06133439,-0.044165038,0.0061335494,0.05612358,-0.050760046,0.014483269,0.008538528,0.031783197,0.0345816,-0.04297928,0.006129899,0.010940633,-0.04533171,-0.041400127,-0.04176585,0.022408472,-0.019526703,0.038846087,0.035077874,0.050504033,-0.02297322,-0.09122257,0.05939556,-0.061928466,-0.0046616113,0.10200859,0.009984563,0.05348053,-0.028735032,0.023604523,-0.010464239,-0.0067224912,-0.05552828,-4.0122877e-08,0.032795496,-0.033022773,0.08111265,0.0119891325,0.038237136,0.026203042,0.012529573,0.0032496247,-0.01800961,0.03286852,-0.015101898,0.11841457,0.006517234,-0.06813141,0.06852457,-0.0046059694,-0.05967022,0.04590257,-0.01707832,-0.0036811323,-0.018685535,-0.04401718,-0.14843333,0.07466782,0.095700614,-0.071803816,0.07750117,-0.07079987,-0.04984063,-0.041389417,0.012005974,0.046650514,0.022186464,-0.056896016,-0.062521055,0.05246626,-0.042521406,-0.03177925,-0.05571177,0.011404665,-0.039135963,0.040067457,-0.086241685,0.024156395,-0.017355885,0.036534227,-0.018925669,0.041519616,-0.0041171373,0.013990093,0.045148466,-0.039889038,-0.018584248,-0.093776755,-0.11777327,0.059067227,5.1833245e-05,-0.075712614,0.0651587,-0.0032265012,0.074122496,-0.06721109,0.12066679,-0.035582233 +1.8.1.3,A molybdohemoprotein.,384,1.0,-0.04025757,-0.020429708,-0.054259907,0.047124024,-0.029078135,-0.08115993,0.039314643,0.060184192,0.00023576434,-0.084457174,0.027200615,0.0072845127,0.013476607,0.022458013,-0.08416375,0.0745026,-0.008594451,-0.05809613,0.008687192,0.08751288,-0.06782315,0.080406405,0.017025065,-0.013238459,-0.0066179894,0.0174287,-0.00568857,-0.014675186,-0.021536617,-0.028767414,0.052188694,0.11013188,0.04235798,-0.009248329,0.066497,0.021419454,0.024336142,0.011719135,-0.0130583495,0.028571827,0.0328244,-0.021843756,0.039483517,-0.004104773,-0.010488694,0.023229389,0.04703805,0.051434927,0.0017630827,0.06071058,-0.027185753,-0.13913296,-0.1129153,0.04817217,0.028719502,-0.022144333,-0.012972364,0.05803435,-0.005419994,0.018069187,-0.061995655,0.065261476,0.10917685,0.023286598,0.052805386,-0.07955556,0.0760577,-0.06930042,0.046473708,-0.017708061,0.033374928,0.013515421,0.025834072,0.06017411,-0.03987243,0.052930422,-0.000104210245,-0.059926145,0.1683743,-0.05138454,0.013171112,0.0030806325,0.0158261,0.018080315,0.051985614,0.013907245,-0.0012840563,0.020569773,-0.075736314,-0.019980913,-0.056422442,-0.06654799,-0.008565386,-0.0030382557,-0.10187181,0.013747104,0.050549332,-0.07878322,-0.1309173,0.061709393,-0.031162782,-0.0023240754,0.06432858,0.014881374,-0.04619702,-0.017719056,-0.012054278,-0.013555144,-0.027281644,-0.022479875,-0.002992153,0.040030174,0.079629116,-0.012066383,0.054043636,-0.015819604,0.0037859823,0.061971236,-0.02122637,0.026620978,-0.03007751,0.042202502,-0.030844845,-0.0004821455,-0.05018581,0.08347785,-0.0114859585,-7.0232633e-34,0.1085772,0.0042322217,0.07614793,0.013488706,-0.03951775,0.037174035,-0.04534484,-0.0074805706,-0.028577974,-0.08400609,0.011307914,-0.05665415,0.06561211,0.04789324,0.058238048,-0.013899955,-0.062075656,-0.0067968206,0.04929436,-0.059048895,-0.07117732,0.072159015,-0.03404565,0.015578541,-0.01252115,0.029381284,-0.031311132,-0.055611905,0.05060476,0.053708125,0.0033507773,-0.009831575,-0.10171631,-0.04114292,-0.030171806,-0.012759931,-0.053155743,-0.103380874,-0.062007055,0.001490826,-0.06635675,-0.021682426,-0.09356826,-0.050595783,-0.009023501,0.017538384,-0.032828048,0.06672678,-0.023202833,-0.011291842,-0.005456909,-0.07627699,0.068863995,0.016823864,-0.10009198,0.016388515,-0.002068963,-0.05671882,-0.011823793,0.011412408,0.03655159,0.08872112,-0.012229069,0.041008368,-0.07521982,-0.085377365,-0.10042862,-0.061168283,-0.013436405,0.057708997,0.05309778,0.02654892,0.08435317,0.012661717,-0.07397851,-0.015910912,0.079350896,-0.030834543,-0.048653822,0.015986348,0.0010791125,-0.0233846,0.05301185,-0.101445556,0.0034304555,0.052841663,-0.00877915,-0.04408699,-0.056587704,0.029553909,0.034175996,-0.00036133965,-0.07072857,-0.083978444,-0.057226524,-4.347411e-34,0.022345463,-0.092354365,0.047413938,0.008495882,-0.0076751136,-0.009422192,-0.019483574,0.021519922,-0.069798365,-0.065598965,-0.0042842743,-0.045364298,0.05435496,-0.0887552,0.08979841,0.020728067,-0.029032305,0.041718036,0.07539013,0.00839556,0.023490973,-0.07161237,-0.0069146245,0.052104637,-0.00010284412,0.020124821,-0.02467494,-0.06786469,-0.023126828,0.059863064,-0.017931947,0.034284253,-0.08609268,-0.07932597,-0.00462898,0.03979796,-0.03665629,-0.0455577,-0.0025023788,-0.036543854,-0.071474284,0.05170412,0.08410588,0.09629447,0.07355531,0.08281242,-0.0070326724,0.047532994,0.12299536,-0.0035586213,-0.068165764,0.030419517,-0.0066671344,0.06970249,-0.011651121,0.032629345,-0.004125916,-0.013411686,0.013308049,0.01154367,-0.01175519,-0.03248667,-0.07891644,0.046289302,0.025582356,0.1416998,0.032043356,0.014735338,0.04900878,-0.059729647,0.062232055,-0.0071731745,0.040791355,0.019512089,0.0210806,-0.03138716,-0.085265785,0.052823722,-0.020449314,0.02003042,-0.02043369,0.0008532868,0.036413625,0.0037941143,0.028395994,-0.10615459,-0.025067177,0.10053536,0.041469797,0.00048852566,-0.05622133,0.053285114,-0.11235002,-0.048273813,0.08099969,-1.8149104e-08,0.022823162,-0.12169214,0.022913884,-0.0986407,0.021698505,0.09543579,0.002425705,0.017148836,0.034414396,-0.014132373,0.0635684,0.020430012,-0.03716054,-0.01284421,0.04234751,0.03601847,0.004733347,-0.01369089,-0.03234967,-0.017807785,-0.007600523,-0.031416308,0.001948522,0.118014626,-0.058859125,0.027271004,-0.00739881,0.03751992,-0.040967144,0.010520695,0.019699985,0.045231987,-0.04661021,-0.054531664,-0.06444206,0.033069145,0.051336855,-0.017640747,-0.014460615,0.041590936,-0.02291928,-0.04362986,0.02052375,0.0031204072,0.08781664,-0.03827754,0.050015435,-0.0026790504,0.0014453146,-0.05764656,-0.038879972,-0.0054349205,-0.012763127,0.063346244,-0.098388694,-0.015584945,-0.021916103,-0.04804494,-0.06800709,-0.03640819,0.01210494,0.03320666,0.112289526,0.04993899 +1.8.1.4,"A flavoprotein (FAD). A component of the multienzyme 2-oxo-acid dehydrogenase complexes. In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes. Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system ({AminoAcid/GlyCleave} for diagram), in which it acts, together with EC 1.4.4.2, glycine dehydrogenase (decarboxylating), and EC 2.1.2.10, aminomethyltransferase, to break down glycine. It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate. This enzyme was first shown to catalyse the oxidation of NADH by methylene blue; this activity was called diaphorase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein [6].",384,0.99999994,-0.08279527,-0.040024474,-0.10419745,-0.068720356,0.12336607,-0.003558608,-0.079970695,0.051113315,0.01039402,-0.031820666,0.007796908,0.051811635,-0.0878184,-0.009710433,-0.02926093,0.035835937,-0.06276695,0.004113204,-0.028875304,-0.019900277,0.066678666,-0.011479922,-0.04649835,-0.020678617,0.0021408047,0.018166542,0.010026874,0.010312641,-0.028106809,-0.03833692,0.097436614,-0.03624964,0.03186613,-0.009518785,-0.03805122,0.13682091,0.029700257,-0.036309626,0.0376269,0.026179172,0.034724403,0.024013547,-0.0069895633,-0.026876684,0.03153435,-0.03563525,0.0040350724,0.05549835,-0.013806612,0.012387249,-0.0313956,-0.019238159,-0.049714666,0.046988677,0.0309734,0.03886743,-0.010912635,0.011460838,-0.047757667,-0.013856565,-0.028059566,-0.031540893,0.02096087,-0.026139399,0.007198018,-0.06553283,0.026694011,-0.07819686,0.046415392,-0.025100023,-0.06853744,-0.05333616,-0.01486606,0.016402038,-0.02973289,0.06827122,-0.08910546,0.0419027,0.04321513,-0.05902869,0.08556031,0.014639723,0.06497348,0.06731897,0.02285945,-0.008951766,-0.051623538,-0.02244569,0.002565134,0.04624942,-0.009107668,0.010409322,0.0115965465,-0.0071826656,0.005966786,0.07016315,0.06844841,-0.018688004,-0.042284813,-0.021222923,-0.01396698,0.079014726,-0.01734414,-0.039923504,-0.08199426,-0.0204633,-0.054427456,0.08946022,-0.05058882,-0.020641612,-0.023485173,-0.0005091367,0.038436227,-0.020616077,0.018836087,0.105051145,0.018632323,-0.03568705,0.01080095,-0.042359047,0.03831867,0.05666504,0.1134495,0.09671753,0.0073459535,0.042548984,-0.12437617,5.268398e-33,0.050944258,0.026302196,-0.047919348,0.0100405915,0.007625912,-0.0547114,-0.093502,0.07044746,0.036512285,0.0074729505,-0.05190187,-0.009328411,0.052045114,-0.068410106,0.0074631544,-0.012290795,-0.029897468,-0.0030915842,0.037493177,-0.02566771,0.03426834,0.017118774,-0.019219475,0.040727194,0.024319705,0.05783313,-0.044998277,0.007847514,0.02099017,0.022106728,-0.0007644476,-0.12599163,-0.08323338,-0.021801947,-0.025827656,-0.03443319,-0.11452644,-0.09233352,0.0126002235,0.03255623,-0.01640388,-0.0425461,-0.0061576944,0.009643461,0.04272363,0.0064004804,0.004208773,0.08381731,0.004813932,0.031839527,0.06160812,-0.07438661,0.1051559,-0.03346065,-0.106987,0.035037626,-0.03398014,-0.025060667,0.055871617,0.11114936,-0.02785302,0.07688952,-0.02305539,0.028727604,-0.035717864,-0.032427717,-0.07067579,-0.030602077,0.02240618,0.094390795,0.023732603,-0.030243717,0.16370885,0.0041035456,0.05146699,-0.056753684,0.0052166823,0.013535929,-0.021218605,-0.0056747063,0.01227983,0.052029803,0.007267857,-0.06460652,-0.03485596,0.029558418,-0.0043601096,-0.08858759,-0.0021555368,0.019445676,-0.0052271043,-0.03284572,0.013781175,-0.042239185,0.019754535,-4.7780822e-33,0.07514734,-0.12599131,-0.015051526,-0.043479443,0.008160243,0.05199816,0.037075456,-0.01915649,0.02871706,-0.07650861,0.0140450625,-0.038148165,-0.047555964,-0.034100384,0.06557738,0.024267556,-0.07134743,0.025771817,0.0017439895,-0.00957092,0.01397198,0.04247373,0.029313937,0.044862214,0.054795887,0.005477614,0.011562346,0.006031505,0.076773554,0.08534367,-0.06536156,0.046636865,-0.052955844,0.009666268,-0.0651264,0.06666249,-0.09207359,-0.029903932,-0.044889167,0.028708456,-0.011097133,0.036441468,-0.010673546,0.030332955,0.054163463,0.06338249,-0.07332749,0.01693984,0.019831043,-0.010536383,0.049752153,0.015280152,-0.06567632,0.08849863,0.048767947,0.088184856,0.05547871,0.04815874,-0.021397157,0.007252044,-0.026751991,-0.118783616,-0.0050058705,0.044851772,0.10566763,0.034452714,0.053390455,0.08124534,-0.0014345074,0.07905194,0.06530094,-0.029396353,0.05343017,0.041366305,0.061249632,0.019015215,-0.0698735,0.015357829,-0.067950025,-0.010835986,-0.008785952,0.0021446408,-0.021166487,0.004776447,-0.0095886495,-0.12456545,-0.017029816,0.1809084,-0.035547588,0.039428968,-0.007828658,0.002376203,-0.020469267,0.059220675,0.08734894,-4.8722928e-08,0.007676789,-0.040529177,0.035104927,-0.01361612,0.06845659,0.03539079,-0.02461304,0.012081479,-0.005193821,-0.062349215,-0.040451664,0.07361144,-0.018610302,-0.016477767,-0.01932474,0.0447419,-0.049213298,0.05711142,-0.02097895,0.004825547,-0.076869436,0.033495903,-0.15277082,0.022791335,-0.021583805,-0.056777008,-0.006434274,-0.0042742267,0.03888294,-0.025420012,-0.00855116,0.054975063,0.022688106,-0.045567468,-0.08783405,-0.03722636,-0.0052314196,-0.014771096,-0.029928984,0.020399379,-0.04686203,-0.03786397,-0.03259081,0.0096822055,0.06253581,0.031478245,-0.006453327,0.030075364,-0.05961267,0.041763056,0.011387375,0.015162949,0.018834379,-0.056634795,-0.11239307,-0.03645346,-0.08471837,-0.101495825,0.01524901,-0.049932882,-0.008857859,0.04466396,0.18658142,-0.0070379316 +1.8.1.5,"Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-sulfanylethane-1-sulfonate); no CoM analogs will substitute. This enzyme forms component II of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.",384,0.99999994,-0.028429007,-0.05904516,-0.083446346,-0.059192374,0.0470458,0.028857095,-0.12017819,0.06932802,-0.015057433,-0.06561747,0.02488156,-0.040028214,0.0074838414,0.022069007,0.06429275,0.08016504,-0.05177781,0.04502075,0.01729441,-0.01610012,0.08417708,0.027916383,-0.018775733,0.056462057,-0.06305427,0.005512591,0.03565003,0.026208822,-0.12836905,-0.045873005,-0.016655548,-0.026647458,-0.004716985,-0.01540334,-0.009155756,0.08303962,-0.05792493,-0.032143507,0.06648274,-0.06407747,0.073419005,0.029688254,-0.03649204,-0.040382296,-0.04390868,-0.00419368,0.0056754653,0.037055146,-0.0281426,-0.044478435,-0.014078115,-0.031692646,-0.013828863,0.05662185,0.015453671,-0.033815954,0.018471716,0.022351157,-0.046022173,-0.028279021,0.009796672,0.0026837825,0.032333005,0.0059407474,-0.030796895,-0.06803738,0.051462688,-0.05407769,-0.0127367675,-0.010052442,-0.16569957,-0.03003844,0.025124595,0.07022929,-0.019749481,0.020317541,0.04736832,0.006267409,0.085059755,-0.06876906,-0.0033743635,0.036677416,0.020310791,0.041403223,0.0028353122,-0.08744164,-0.012506718,-0.014355218,0.048531417,0.018613908,0.13497066,-0.034646925,-0.023949299,0.05436557,0.0013805922,-0.019251574,0.033642836,0.040109616,0.011582901,-0.022711784,0.01581634,-0.00037428507,0.0163607,-0.082117125,-0.012511215,-0.041565884,-0.007873037,0.08002609,0.033005778,0.040184043,-6.049394e-05,-0.064748704,0.085357495,-0.020552266,-0.04760356,0.09180281,0.0024984595,-0.01872047,-0.06792308,-0.060301866,0.057230957,-0.046998527,0.056268193,0.044121664,0.008326443,-0.030830545,-0.115226775,3.3331576e-33,0.043577753,0.061516505,0.048705637,-0.030480526,0.0339469,0.024651356,-0.01798784,0.09786676,0.0037940838,-0.026109194,-0.10438736,-0.0014742168,0.03520997,-0.01823017,-0.07889906,-0.04782123,-0.057848133,0.06582955,0.005983978,0.027693521,0.0063114846,-0.0075734523,-0.06448994,0.041830238,-0.022186896,0.03552765,0.0028437956,-0.024245009,-0.0022139736,0.006838865,0.013051037,-0.11351044,-0.04893148,0.05885794,0.0064443345,-0.06741307,-0.03700459,-0.041351527,0.012480759,0.013500837,0.02370046,0.009816203,0.02936379,-0.050096273,0.023282608,-0.09741711,-0.06365405,0.12444586,0.030319747,0.10487367,0.03459029,-0.08090958,0.080200896,-0.006964715,-0.07277727,-0.009264039,-0.08197943,0.030874558,0.10859633,0.014458374,0.009891645,0.06951368,-0.006188949,-0.031024413,-0.0032840427,0.05456349,-0.043792114,-0.027822306,-0.048032384,0.081170104,-0.045707546,-0.010941635,0.043564737,0.057102248,0.031853195,-0.059425782,-0.015624648,0.05657591,0.050075244,0.034231693,-0.07209235,0.033810377,-0.005064817,0.002242534,-0.02646035,-0.03334957,-0.012153144,0.036940265,-0.025994057,0.07626031,0.06404532,-0.07714042,-0.05992731,0.038174815,0.064010285,-3.7531294e-33,0.063913725,-0.03636334,0.06499702,-0.06431628,0.041182738,0.033390682,0.08220314,-0.0023584287,0.004336686,-0.045309935,0.08313504,0.0170583,0.011284842,-0.015236735,0.040502105,0.059703644,-0.023233846,0.059399273,-0.03980296,-0.0016791399,0.105888054,0.038522407,-0.038432393,-0.014318062,0.018433277,-0.0305865,0.00881348,0.010739733,0.10768701,0.070649154,0.0026018077,0.009314754,-0.077522986,0.016509335,-0.029916493,-0.011670663,-0.09959513,0.032723304,0.02656053,0.034951206,0.042824004,-0.0054960377,-0.0032919967,0.0909949,0.04307854,0.045495365,-0.106598675,-0.021291297,0.07624561,-0.004996867,-0.05680187,0.06865324,-0.05304659,0.010042258,-0.016520558,0.06544867,-0.01023528,-0.012317486,-0.04156452,-0.04437123,-0.09746289,-0.05652056,0.049169898,-0.05138972,-0.0033732664,0.025032489,0.0078021744,0.07688907,0.09183755,-0.048493773,0.06827596,-0.025133934,-0.02661313,-0.075696155,-0.03247827,-0.016559048,-0.044566,0.019298567,-0.0054472764,0.034728464,0.056854896,0.0040643476,0.07787991,-0.06742395,-0.015170609,-0.0183436,0.0339092,0.123506896,-0.047720093,-0.020494495,0.024313873,0.0011735535,0.03337538,0.041618325,0.09118612,-5.3290826e-08,-0.035608944,-0.08251625,0.09346351,-0.001795475,0.008602812,0.04200906,-0.0045683566,0.05048876,-0.003466632,-0.019523578,0.029638965,0.09082843,-0.013032818,0.009213854,0.041109018,-0.00030838768,-0.08706957,0.026380142,-0.03290626,0.022906918,-0.083973326,-0.08558961,-0.11111345,0.013349633,0.057636984,-0.0599835,0.016805116,-0.06403629,-0.030263493,-0.043664724,-0.00070882024,0.02785885,-0.044392038,0.010433608,-0.06707261,-0.013703986,-0.05288148,-0.010316645,-0.05484348,0.051199965,0.00913263,-0.094665825,-0.0307827,0.03253131,0.12898986,0.03619325,-0.031498652,0.032647967,-0.054135833,-0.030439049,0.0472025,0.024247913,-0.023225024,-0.089255005,-0.050623685,0.079379424,-0.008300387,-0.029337028,-0.030525329,0.02898247,0.02436664,0.026983231,0.17368452,-0.03361403 +1.8.1.7,A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres.,384,0.99999994,-0.037189897,-0.1121679,-0.0777545,0.043475367,0.07084953,-0.010567071,-0.018385468,0.07020299,0.068238236,-0.050565794,-0.018830836,0.058448873,-0.06672857,-0.0076984363,-0.03620859,0.01761214,-0.017587371,0.04393149,-0.096038155,0.0012516815,-0.02429265,-0.066403076,0.06655504,-0.013811527,-0.0402246,0.017818997,0.03951013,0.00036078473,-0.039688982,-0.027906952,0.08371849,0.06710431,0.08281955,0.050554164,-0.082800396,0.061047357,0.011260293,-0.012621484,-0.028252684,-0.03994745,0.04240617,-0.004081673,0.054707553,0.025925398,0.08891914,-0.0112099545,-0.08587936,0.07684795,0.010878107,0.036659945,0.025711345,-0.015904961,-0.09355725,0.09705544,-0.012658835,0.083411165,-0.027795155,-0.0037403607,-0.017610058,0.016956821,0.00907227,-0.027370336,0.05257208,-0.021729546,0.017678423,-0.06643211,-0.0012049219,0.019986639,0.04245157,-0.03013438,0.007904366,0.028385542,-0.05425185,-0.008080706,0.05136384,0.06174894,-0.09755362,-0.010058844,0.033018596,-0.018286314,0.11281224,0.017774006,0.13393612,0.12947655,0.05486327,-0.014416936,-0.016251592,-0.03226698,-0.056543462,0.038094077,-0.035894796,0.07414996,-0.014875162,0.022746336,-0.07744739,0.04083078,0.013079395,-0.016174886,-0.123831,-0.007980246,-0.011869263,0.009543805,-0.01982206,-0.0020012099,-0.02972743,-0.079945646,-0.02954583,0.060699474,-0.031135935,-0.05471176,0.043996125,-0.011788921,0.07712064,-0.046524946,-0.0054022875,-0.013313934,-0.008786478,-0.052744698,-0.0008479401,-0.058274824,-0.04320401,0.0771291,0.050956186,0.031873517,0.009749464,-0.040061507,-0.048536383,6.060934e-34,0.035896316,0.0051022717,-0.008494515,0.101315804,-0.043310232,-0.000744914,-0.056382045,-0.031773545,0.056392677,-0.0059649204,-0.043819867,0.018308388,0.021138119,-0.007265344,0.081129044,0.038869444,0.00010299565,-0.022503506,0.07746475,-0.12673634,0.036691595,0.035923027,-0.019337239,0.002417479,0.05115278,-0.035771072,-0.08014876,-0.011026914,-0.009144648,0.024225235,-0.017880347,-0.05267031,-0.05301427,0.02443397,-0.016026607,0.091729,-0.08120527,-0.06717264,-0.08805834,0.019740487,-0.049625494,-0.04924438,-0.0032189896,-0.035858206,0.032946106,-0.016879844,-0.063247636,0.086427845,0.008318458,0.07326084,0.04923318,-0.034688853,0.13483188,0.056745403,-0.07926973,0.008052403,-0.01781775,0.007735451,0.046586815,0.03628209,0.0065893997,0.03107471,-0.07287238,0.06986983,-0.061241258,0.023601936,-0.028211288,-0.06060183,-0.01910768,0.14671719,0.0781714,0.011950404,0.10776499,0.0005026177,0.046665143,-0.025896184,-0.022633672,-0.05226132,0.011876403,0.0444152,0.008885953,-0.036347613,-0.030782036,-0.023498954,-0.06256692,0.0049807495,-0.0015879273,-0.0150556285,-0.001991619,-0.0017635648,0.07100082,-0.06427897,-0.01718859,-0.02117064,0.054328874,-8.4497146e-35,0.003961204,-0.07307685,-0.032470968,0.034897484,0.022234555,0.024517886,0.018222567,-0.020588111,0.057778593,-0.04843393,0.062147193,-0.06013181,-0.0673351,0.037307266,0.032756433,0.06204138,-0.102473274,0.038837653,0.0414747,0.044075247,-0.074008204,-0.04501127,0.038810976,0.1440129,0.04902642,-0.0040457537,0.025047436,-0.035201445,0.03549204,0.04330309,-0.012550092,0.015509752,-0.094378345,0.0075056776,-0.07120145,0.019960186,-0.03185793,-0.02174961,-0.03105821,0.017330011,-0.044296056,0.0053991987,-0.0055849957,0.010520873,0.089676574,0.06742936,-0.025582979,0.07735334,0.078627,-0.06867678,0.017566156,0.026889391,-0.010103698,0.08257035,0.078619264,0.07226688,0.017610004,0.029380672,0.0044770306,-0.015064619,0.0026367067,-0.12898387,-0.014970956,-0.0051200013,0.009959568,0.06319476,0.028542144,0.17165478,-0.03513889,0.025243087,0.11800404,-0.017790148,0.028660374,-0.0024512887,0.013230617,-0.05594428,-0.00452039,0.074494876,-0.00015241567,0.06938137,0.033382762,-0.017362198,-0.016030932,0.0031846478,-0.0611376,-0.08616603,0.013188184,0.050401136,-0.029070105,0.014752712,-0.015942272,0.029034326,-0.02786484,-0.062409215,0.05606628,-2.6847694e-08,0.03665142,-0.015940923,0.017433679,-0.043423124,0.04679874,-0.0036306817,0.0044017006,0.030060211,-0.041600637,0.03723427,-0.04634587,0.08684439,-0.04794215,-0.06258788,0.029798586,-0.008955047,-0.004937472,0.021520894,-0.027333928,-0.047551304,-0.01537244,0.04051875,-0.08254816,-0.009135816,-0.0612214,-0.022033235,0.013666359,-0.09880399,0.067589544,-0.009551654,0.07063638,-0.01171842,0.019364785,-0.024085887,-0.14544906,0.010142831,0.036889438,-0.03209357,-0.022412533,0.044218797,-0.13059865,-0.04625857,-0.008325541,-0.033495445,-0.021188503,-0.00058560615,0.05895632,0.004528624,-0.045730263,-0.03846952,-0.027497323,-0.015183355,-0.0058122776,-0.022200601,-0.07474392,-0.020290757,-0.02364286,-0.031184748,0.016626699,-0.10939152,-0.041966096,0.058458507,0.06568523,0.009593053 +1.8.1.9,"A flavoprotein (FAD). The enzyme restores the activity of thioredoxin by reducing an internal disulfide bridge. cf. EC 1.8.98.8, thioredoxin-disulfide reductase (factor 420-dependent).",384,1.0,-0.08459798,-0.04258088,-0.070674114,0.00832894,0.12471123,-0.021356013,-0.054925516,0.11147109,0.014677449,-0.0440601,0.008221553,0.0891359,-0.07651392,0.002283759,-0.03764744,0.045197748,-0.0029227615,0.062075313,-0.06236339,-0.057205707,-0.05296268,0.004671707,0.029347928,-0.02490405,-0.0033453053,0.0014575863,0.028228672,0.0044832886,-0.015568244,-0.032707423,0.031383384,0.026381629,0.03548504,0.0119562885,-0.0786449,0.09333214,-0.026209995,-0.020157252,-0.028995361,-0.082536116,0.018215183,-0.009978661,0.029817546,-0.0043432266,0.06212235,0.04430092,-0.07191141,0.07850036,0.0083412705,0.02969226,-0.015434475,0.004152214,-0.020074109,0.06579474,-0.018651264,0.04080262,-0.029438866,-0.07114389,-0.041356057,0.02989712,0.001456234,-0.010391627,0.016821047,-0.00951574,0.08712168,-0.055988893,-0.012603581,0.02480934,-0.0030586524,0.0047121365,0.018449338,-0.0072904606,-0.03802374,0.023908542,0.06388226,0.022862561,-0.08691612,-0.025840212,0.0798267,-0.021604609,0.10389982,0.04705005,0.106385924,0.1294971,0.059651904,-0.063933164,-0.015592751,-0.040089667,-0.06909751,0.08648697,0.06130333,0.045426898,-0.017716475,0.03913856,-0.08281033,0.033840545,-0.00061111903,0.006550858,-0.084765375,-0.0056196507,-0.03799583,0.021396138,-0.06941828,-0.045255933,-0.010208801,-0.07632301,-0.012296287,0.08082884,0.00694495,-0.03820964,0.042396676,-0.022844138,0.040740218,-0.04948011,0.0039478173,0.026996113,0.012335279,-0.031550147,-0.027755285,-0.051698,-0.0061454745,0.08763525,0.024594482,0.050562046,0.0030495583,-0.03526033,-0.1089789,2.5976747e-34,0.047444105,0.01047864,-0.06709999,0.005143861,0.025510767,-0.0079081105,-0.039590836,-0.024096996,-0.018701648,-0.014460837,-0.06355278,-0.03192783,-0.06815789,-0.042756353,0.08331102,-0.04720312,-0.017322777,0.011324736,0.09696946,-0.116620935,0.04156636,0.05988123,-0.017049834,-0.017764704,0.05540568,0.030365827,-0.01755552,0.07454251,-0.020085473,0.022092834,-0.035741184,-0.04719369,-0.042258196,-0.006075713,-0.00968566,0.064893514,-0.044578232,-0.07419651,-0.12208695,0.03364975,-0.006080029,0.023989458,-0.085983865,-0.024220062,0.033116,-0.108628966,-0.04991981,0.08140817,0.002497754,0.057331692,0.024164185,-0.057118542,0.11590234,-0.0001221997,-0.08847253,-0.020268468,-0.049839694,-0.015046314,0.022622839,0.037671205,0.012609597,0.00854767,-0.047242913,0.120297514,-0.059440274,-0.022600237,0.01481627,-0.063166566,-0.02336641,0.11440637,0.029083401,-0.01206364,0.042965606,-0.024658184,0.036402147,-0.06408893,-0.029433526,-0.028868757,-0.015668765,-0.027773311,0.0018245908,-0.013684546,-0.014241978,0.03380142,-0.013677245,0.057860598,-0.016096523,-0.06529675,0.04512662,-0.027672827,0.037709065,-0.10451686,-0.010381995,0.026449164,0.048692282,4.959617e-34,0.04414573,-0.083621584,0.08168866,0.013262374,-0.013544704,0.04091461,0.04291979,0.010585958,0.03327405,-0.036090095,0.05523334,-0.07032392,-0.012896852,-0.0096083395,0.039795574,0.049231566,-0.041763116,-0.021543913,0.012208684,-0.010028341,-0.07046927,0.017394733,0.03476703,0.07947809,0.016011963,0.029180491,0.012051829,0.027839338,0.014600652,0.002756607,-0.030876387,0.0016459686,-0.043603845,0.008662713,-0.06676121,0.09049479,0.00042501424,0.019827878,-0.051407184,0.024928013,0.005937107,0.033712924,0.021651637,0.03889797,0.03880445,0.044848025,-0.042212147,0.008677228,0.08723767,-0.098033205,0.0780995,-0.004745455,0.02874433,0.12383576,0.036633942,0.006842993,0.05935809,0.03591794,-0.032728117,0.002880744,0.02654826,-0.13520409,-0.01269192,-0.00013597692,0.09492203,0.019538008,0.0029150196,0.12086672,0.012974963,0.025561173,0.07214343,0.0021922996,0.05638511,0.018390067,0.038874134,-0.022345372,-0.01670817,0.12264515,0.027333073,0.08000475,0.04012244,-0.0119129885,-0.017924285,0.016212314,-0.06077588,-0.099779755,0.04970423,0.120436385,-0.023116125,0.04570061,-0.024913842,0.0119360145,-0.025840014,-0.050735217,0.015989373,-2.9659887e-08,0.026417349,-0.08428343,-0.027601238,-0.07411972,0.08293007,0.010732907,-0.014002303,0.033221643,-0.024179596,-0.006283301,-0.07031272,0.12557705,-0.008265519,-0.076843746,0.051312298,-0.03341984,0.024574157,0.026576312,-0.011372611,-0.032824233,-0.053774077,0.03575532,-0.091882974,0.011369979,-0.02611715,0.017186671,0.027229758,-0.058473065,0.049058504,0.015692214,-0.0095008295,0.017322896,0.020356305,-0.023247171,-0.09023177,0.07722021,0.024050752,-0.07589848,-0.04000707,0.017582761,-0.10573598,-0.010293204,-0.025023367,-0.021523478,-0.012220295,-0.027495999,0.06972553,0.00068397506,-0.089983255,-0.028804617,0.02404192,-0.036512725,0.034154367,-0.04634021,-0.08870666,-0.0003040273,0.012274263,-0.028415209,-0.060520183,-0.117073685,0.06324734,0.044938337,0.1460035,0.036165077 +1.8.1.10,"A flavoprotein. The substrate is a mixed disulfide. May be identical to EC 1.8.1.9, thioredoxin-disulfide reductase.",384,1.0,-0.07126508,-0.027762968,-0.07376119,0.0030049337,0.10234122,-0.025735125,-0.0043910714,0.104735546,0.030716322,-0.110084705,0.05954601,-0.025301252,-0.0681595,0.004304222,-0.05462399,0.004816046,0.014239357,0.0009279473,-0.05400744,-0.019766614,-0.032995664,0.0075015333,0.004680451,0.014841076,0.010722139,0.02910209,0.05745784,0.026509183,-0.0058735716,-0.082812496,0.037395444,0.010909092,0.074840955,0.021971656,-0.07485334,0.098472364,-0.06584168,-0.09011944,-0.015165612,-0.0674446,0.05484426,-0.006331286,0.031019943,0.0077907257,0.0368381,0.027911725,-0.06282258,0.10453598,0.0080704475,0.048433498,-0.000108142136,-0.02984228,-0.06500786,0.051157095,0.023596846,0.025131771,-0.059059016,-0.02055885,-0.054066934,0.018661223,0.02666703,-0.00051221676,0.062793486,-0.009936746,0.032800123,-0.047990978,0.033557482,-0.01912025,0.029006403,-0.007949687,-0.010590315,-0.029952463,-0.04519208,0.080593236,0.058152325,0.065952554,-0.014712562,-0.0011789985,0.064796925,-0.01987116,0.049082894,0.019245934,0.005173285,0.092877164,0.060098447,-0.060696658,-0.047527675,-0.0395705,-0.024139808,0.035214264,0.0030943926,0.08255704,-0.0008740624,0.027972411,-0.045414984,0.045515332,-0.00587611,0.05584293,-0.04615857,-0.0067045335,-0.02786735,0.030300219,-0.051919747,-0.003923019,-0.04181473,-0.059402447,-0.021860253,0.037384517,-0.02968606,-0.08564156,0.03592057,-0.051253986,0.04611881,-0.067371674,0.03431662,0.013805585,0.0077030337,-0.014273142,-0.014880978,0.012729136,0.015048275,0.057769757,0.032511495,0.056739446,-0.0276799,-0.023268133,-0.12523404,-3.892824e-35,0.044547755,0.0119654825,0.004039395,0.002541759,-0.0045575434,-0.008180209,-0.046657644,-0.006234508,-0.061841317,-0.04176492,-0.07865969,-0.012748968,-0.025730966,0.011560679,0.08471081,-0.06001732,-0.024051325,0.042823892,0.06218475,-0.064352125,0.010785064,0.034267597,-0.05052792,-0.040040094,0.076499,-0.014039974,-0.054934844,-0.019421423,0.00010411085,0.018362205,-0.012051082,-0.059397683,-0.03305454,0.011307607,-0.0072718663,-0.0064777704,-0.054309998,-0.06037411,-0.08840697,0.029898016,-0.015190046,0.01279367,-0.014846613,-0.022524552,0.05673003,-0.057560835,-0.07766301,0.08071747,0.061551623,0.011835741,0.011373805,-0.073617205,0.1756546,-0.030129172,-0.04322128,0.012437769,-0.022417089,0.06553258,-0.006436291,0.062697195,0.013328463,0.1268799,-0.093492866,0.076302506,-0.06734302,0.0060937065,-0.05122348,-0.05107574,-0.012946739,0.061976627,0.044040743,0.023130013,0.08439834,-0.009520119,0.022584315,-0.059509046,-0.09918058,0.021401366,-0.008836818,0.03154157,-0.03750337,-0.012243206,-0.041794524,-0.019780183,-0.1278036,0.07308366,0.022830103,-0.018962122,0.041173942,0.02086722,0.021805106,-0.06419449,-0.044690486,-0.032426428,0.04832268,-2.3054658e-34,0.015854292,-0.09014452,0.012609257,0.03022355,0.0032703143,0.017051177,0.0695385,-0.014408398,0.020737238,-0.005591079,0.082464434,-0.06327272,-0.0361458,-0.05309315,0.021473331,0.07620611,-0.074217305,0.08101249,0.06112475,-0.013579258,-0.05036805,-0.016029716,0.07097796,0.07920562,0.03423908,-0.016562141,0.057296783,0.04766599,0.051981658,0.0077382727,-0.080189794,0.013604061,-0.010457415,-0.0014716339,-0.06022058,0.07458666,-0.041505814,-0.043643888,-0.01373606,-0.012122954,-0.014632392,0.05614596,0.026765702,0.042173304,0.039732788,0.10773437,-0.0052925684,0.055173922,0.07143045,-0.06777192,0.03763224,0.021351866,-0.017944986,0.1497855,0.0052261227,0.039860122,-0.00380789,0.069391236,0.014854104,-0.0044848016,0.007897144,-0.12748435,-0.038825616,-0.025757315,0.0743596,0.020352447,-0.018646296,0.10295693,0.010759272,0.00754475,0.1358638,-0.053503145,0.0492099,-0.014638585,0.037085693,-0.053709272,-0.030668287,0.09269111,-0.011067419,0.03759101,0.047529157,-0.039391268,0.007966471,0.030415408,0.0077767256,-0.060334716,0.018196477,0.07232437,-0.03058497,0.07835793,-0.016723152,-0.02700537,-0.0977871,-0.013032231,-0.004886764,-3.0372174e-08,0.095561035,-0.0892823,-0.006402423,-0.09696888,0.08366204,0.009520826,0.021661473,-0.012870775,0.0033641804,0.028186822,-0.044932682,0.0706261,-0.015762007,-0.0815997,0.06158438,-0.019183345,-0.016225938,0.040576722,-0.00016344046,0.0061886567,-0.024697747,-0.0017386583,-0.09303903,-0.01007747,-0.066844136,0.020447036,0.0067159785,-0.033492915,0.068040796,-0.05962557,0.043330155,0.049248368,0.013842776,-0.047044106,-0.094099954,0.044379048,-0.048108652,-0.013765184,-0.039883412,0.05398298,-0.11623167,-0.05675081,-0.022677545,-0.007663751,0.05467486,-0.008679215,0.052597407,-3.9283557e-05,-0.04533909,-0.045975834,-0.003092383,-0.040042963,0.00787069,-0.038972117,-0.089530334,-0.047293965,0.01207976,-0.025455216,-0.011031111,-0.09088299,0.048266616,0.066907406,0.17612521,0.05092109 +1.8.1.11,Also acts on lipoate.,384,1.0,-0.021615742,-0.11968052,0.042052254,0.049160466,-0.04595405,0.04892321,0.10215822,-0.044257764,-0.004915076,-0.03918486,0.036558487,-0.029415581,-0.09194561,0.099594414,0.045723144,-0.023741161,0.016041936,0.076470934,-0.017297467,-0.005549524,0.0691161,0.03665686,0.080720805,-0.035712775,-0.0860781,-0.007416198,-0.033262927,-0.021009414,0.041731328,-0.09328755,0.038444895,0.01952901,0.022681335,-0.080203794,-0.085301705,0.058147494,0.018712003,0.059222814,0.008762265,0.044953078,0.032829784,-0.079975985,-0.024135983,-0.023881128,0.03078382,-0.043653462,0.013424472,-0.005975868,0.046481557,0.062408037,-0.042105068,-0.13115835,0.0054859878,0.0028553142,-0.04457685,0.02615777,0.03603718,0.0031956453,0.021320676,-0.02336112,-0.02968946,-0.011054104,0.010271586,0.075681746,-0.04785424,-0.0035008006,0.029473357,-0.019704334,0.018366344,-0.022613196,0.04996508,-0.04617017,-0.046261262,-0.00034218762,-0.02162862,0.021462679,-0.027485225,-0.085382804,-0.035793014,0.015514721,0.014586106,-0.10388227,-0.0027350895,0.057971235,0.02446687,-0.034810226,0.022840034,-0.14627983,-0.09266514,0.059509,-0.02932606,0.006716871,-0.054318037,0.03818557,-0.05760775,-0.018629076,-0.029066168,-0.0075717503,-0.047398042,0.049820557,-0.03484302,-0.08201778,-0.007581743,0.024424016,0.036102887,-0.050919116,0.005805531,-0.108567186,-0.04422685,0.0022523096,-0.03394507,-0.05908214,0.040304717,0.038756244,0.0020955189,0.05840055,-0.036866467,-0.02642187,-0.08080512,-0.027454223,0.019915467,-0.051088445,0.0061270935,0.007954672,-0.02319743,0.020003537,-0.045081694,-2.7168073e-33,0.025973847,-0.069564916,-0.0026911816,-0.02499048,0.08232407,-0.0055831345,-0.035672203,-0.023628388,-0.0014432237,-0.012425546,-0.0005707163,-0.109638155,-0.005809946,0.075494744,-0.050093096,0.026003364,0.023642978,0.07169394,-0.0042064795,-0.03149812,0.02915643,0.12036198,-0.032603927,-0.027288644,0.00982383,0.026555346,-0.0094936425,-0.05295273,0.013736349,0.013885774,0.03275445,-0.037603267,-0.002768252,0.004207982,0.02934952,0.09187143,-0.021773469,-0.06487617,-0.07765478,0.021115398,0.017047968,-0.005147527,-0.044132072,-0.029973581,-0.05001678,0.015426545,-0.08769845,0.09088587,0.12867928,-0.023804186,0.0756357,0.041440703,0.07934067,0.018792156,0.016092455,0.034659028,0.019119238,-0.0223723,0.032807693,0.026292823,-0.0009884532,0.06629376,-0.044891533,-0.051781002,-0.038111802,0.026003765,-0.059314903,-0.021614425,-0.045502815,-0.018929968,-0.013805715,0.008705625,0.070011064,0.02561928,-0.0027304396,-0.0650619,0.023920998,-0.02532281,0.010543728,0.026878715,-0.008282157,-0.02282483,0.08341176,-0.048733927,-0.07647099,0.0074496423,-0.023870673,-0.09024475,0.017569838,0.042268116,0.011707798,-0.012530325,-0.04397853,-0.022990603,-0.102982596,9.256216e-34,-0.0743206,0.00781525,0.005907541,0.085368104,0.043348726,0.09783087,-0.007777815,0.094568096,0.07683143,-0.013955178,0.0134283705,-0.01219748,-0.050643254,-0.022815393,0.06230908,0.087938085,0.011231635,0.06548084,-0.008082748,-0.009394044,-0.024466807,0.011611827,0.03599245,0.12965722,-0.022965426,0.07781416,0.011151681,0.006070755,-0.04186353,0.032982714,0.0014875521,0.008709269,-0.116881154,-0.09584591,-0.07011934,0.05746205,-0.04884931,0.023434794,-0.08668271,-0.027586272,0.0218798,-0.08228628,0.119523264,0.078207396,0.027268378,0.007924067,-0.011993495,0.047438566,-0.086299255,0.003311057,-0.077472255,0.018430108,0.036866233,0.0816871,0.048822265,0.099104375,0.031927593,-0.06910793,-0.0065790373,-0.055035006,-0.003477502,-0.010335646,-0.047482863,-0.023189465,0.09851451,0.06475492,-0.029427337,-0.02310348,0.06182354,-0.004781624,0.07607449,-0.004160457,-0.004876767,0.016594991,-0.05439624,0.040859472,-0.0460968,-0.08439269,-0.05381688,-0.032910388,-0.008389671,-0.0111465985,0.011125375,-0.06039501,-0.0016346303,0.034067363,-0.0549832,-0.038956646,0.0042561423,0.057403438,-0.032318458,-0.03414087,-0.05534294,-0.021215148,0.07914387,-1.646494e-08,0.0141253695,-0.0067925043,0.09434404,-0.050714977,-0.032946713,-0.00025740484,0.12592451,0.0051085413,0.039449897,-0.02570562,-0.011684421,0.08879421,0.12685807,0.035094947,0.097598776,-0.012484447,0.024820652,0.046551514,-0.11688834,-0.04441333,-0.08061851,-0.03110241,0.02649569,0.037442073,-0.067627445,-0.030073522,0.009632755,0.13225977,0.0030248133,0.011826696,0.061766177,-0.02547437,-0.015645383,-0.013135729,0.037754923,0.030337509,0.03136361,-0.05910351,-0.054729585,0.10693726,-0.029214561,-0.00033414038,0.04798731,0.03803875,0.00055620767,0.010721285,-0.0044581313,0.012728086,0.06007264,0.04439079,0.048523743,0.0431265,-0.013270189,0.04060525,-0.0371586,0.039035536,-0.013461794,0.01707868,0.045330763,0.030411426,0.016858088,-0.063765965,0.16316815,0.027575493 +1.8.1.12,"Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC 1.8.1.7, glutathione-disulfide reductase)",384,1.0,-0.021192439,-0.042510387,-0.06809936,-0.002491971,0.045243476,-0.0035829525,0.014782411,0.050438475,0.009729006,0.008873732,0.069281854,0.0011135674,-0.035636805,0.074531846,-0.13814059,0.010229465,0.034883708,0.0040229578,-0.00062484754,-0.08315324,-0.006305553,0.04717728,0.038499217,-0.026904982,-0.0042909333,-0.016415821,-8.814889e-05,0.026059873,-0.008044571,-0.019313026,-0.052218072,0.014143849,-0.007998475,-0.030828377,-0.035147127,0.044666037,-0.021406442,0.038005114,0.021718223,-0.013446696,0.000376732,0.014698857,-2.8334225e-05,0.029581428,-0.017861016,0.0024928683,0.010748557,0.08688828,0.09432274,-0.0055341586,-0.030772174,-0.061051853,0.005249559,0.066368856,0.061518967,0.05464786,-0.0074574864,-0.011277217,0.01563157,0.047011085,0.015963053,0.004089888,0.040902488,-0.08033101,0.079995684,-0.066954345,-0.056487706,0.009323148,-0.003805312,-0.03607747,-0.026375081,0.008576313,-0.04527548,0.019232895,-0.0011822789,0.051544227,-0.093804196,-0.04036157,0.04037444,-0.04139403,0.016974831,-0.055893324,0.07779539,0.07938424,0.07645843,-0.012757624,-0.020466685,0.074717894,0.064770296,-0.0108065065,-0.01714745,0.055195127,0.022308374,0.017157905,-0.08392302,0.07465287,-0.042593114,0.061110124,-0.099599466,0.009957496,0.05408084,-0.04212647,-0.041508656,-0.074070536,-0.05650453,-0.017070966,0.029194457,0.082922705,0.056572266,-0.04882801,-0.050495725,0.019303072,0.059557118,-0.007847239,-0.077857,-0.013469052,-0.024661245,-0.025405243,-0.032276157,-0.022593942,0.01260335,0.061356805,-0.035698194,-0.024319554,0.022622103,-0.010934486,-0.0366615,5.5002766e-33,0.06627836,0.058895715,0.009358529,0.12315234,-0.016930163,0.0038700742,-0.0499062,-0.045451906,0.006791771,-0.07226503,-0.06684701,-0.062198844,-0.046545226,-0.048235934,0.010871418,0.019233318,0.008863762,-0.02984627,0.11334124,0.004963027,-0.0028734214,0.019486865,-0.03774855,-0.11591599,0.056524213,0.007820008,-0.059388362,0.022630751,0.01027498,-0.009793231,0.045302227,-0.06075463,-0.07038724,0.08765869,0.020759022,-0.014844571,-0.015957106,-0.08532067,-0.13581304,-0.023396194,-0.055519633,0.036591604,-0.0018765201,0.014502298,0.07119095,-0.05911789,-0.0348523,0.094888456,0.08538202,0.11933395,0.07216715,0.0031201257,0.15897442,0.019827057,-0.08062633,0.03745496,-0.013121141,-0.024835456,0.047923878,0.050455477,-0.0015925156,0.04049326,-0.080728434,0.010277044,-0.064186506,0.011904609,-0.03937899,-0.10313063,-0.029678663,0.05411754,-0.0011508261,-0.026526723,0.02856949,0.032791696,0.02022559,-0.048696928,-0.034695987,-0.008819836,0.00966637,-0.047453526,0.03335982,-0.07698002,-0.04069278,0.003194066,-0.11582159,0.052275315,0.012784175,-0.033025373,0.06992259,-0.03833164,0.07897946,-0.13917483,-0.031351633,0.00358167,0.07956666,-3.1989496e-33,0.029430458,-0.07672225,0.04857286,-0.0148651935,0.0084157735,0.018172635,0.036856353,-0.057520196,0.009477779,-0.010252576,0.07435807,-0.057181478,0.032756764,-0.022106152,0.03076175,0.0035622972,0.0010223745,0.04825668,0.076467395,-0.06026658,-0.06300114,0.089308694,0.020054607,0.033389613,0.004275846,0.03166488,0.058189515,0.03681936,0.039818577,0.012826926,0.00038285318,0.026031494,-0.0353539,0.016906956,0.046933968,-0.005346482,-0.046990123,-0.003406418,0.018054469,-0.0012563292,-0.0053543737,0.05009314,0.020498464,0.073239885,-0.01121782,0.09947151,-0.10067877,0.048481937,0.05584017,-0.04213615,0.0011490196,0.04602773,-0.06533982,0.032775037,0.12152394,0.024963832,-0.025354352,0.03844466,-0.012329414,-0.025783561,-0.0531936,-0.066205256,-0.032052796,0.037097506,0.05324086,0.034881033,-0.1287375,0.14590903,0.03140966,0.0864682,0.06923644,-0.06645832,0.0793056,0.013804479,-0.032225166,-0.06825522,0.01035472,0.010844642,0.04496456,0.05957729,0.062413506,-0.039051384,0.02758128,0.0275903,-0.019993315,-0.108881034,0.01023157,0.080692194,-0.007661786,0.00676252,0.0065281414,-0.019214673,0.017526284,0.05981629,0.08262142,-4.1680195e-08,0.03141864,-0.051348418,0.05655623,-0.10427984,0.013692716,-0.05661799,0.0017372102,0.014137397,0.022190243,0.03705819,-0.054113444,0.020013547,0.046482116,-0.03932535,-0.016050868,0.06965302,0.028275447,0.042628046,-0.016897967,-0.02075609,-0.079294,0.026692057,-0.09396733,0.003439994,-0.035336565,-0.020873414,0.07235354,-0.052854057,0.03368551,-0.049871545,-0.038550068,-0.023445709,0.04339102,-0.06066474,-0.14730322,0.08085059,-0.056870393,0.037260834,0.004899347,-0.046300538,-0.030520316,-0.04063239,0.037312977,-0.010177982,-0.0070615937,-0.018016713,0.031970695,0.01579753,-0.012841617,-0.04709333,0.0034829783,0.030553697,0.017765222,-0.07457978,-0.107662134,-0.039947663,-0.011860403,0.029308802,0.0044127335,-0.056937385,0.0028714593,0.09317872,0.1138278,0.013461954 +1.8.1.13,"Contains FAD. The enzyme, which is found only in halobacteria, maintains the concentration of gamma-glutamylcysteine, the major low molecular weight thiol in halobacteria. Not identical with EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.14 (CoA-disulfide reductase).",384,1.0,-0.028366173,-0.04878959,-0.07230158,-0.042829234,0.08033207,0.050904825,-0.05348819,0.11871663,0.044267647,-0.032656617,0.0005512176,-0.07161256,0.0044169766,0.020945044,-0.047320306,-0.03710374,0.02812419,-0.022576224,-0.069092974,-0.0706002,-0.019262195,0.03425956,-0.025326539,0.006648924,0.0048505175,0.030538613,0.06490589,-0.048999522,-0.053530514,-0.08186359,-0.017238853,-0.06353718,0.08011019,0.0035932115,0.061862905,0.06895316,-0.0024288248,-0.09488987,0.07521043,0.0012940508,0.017103678,0.018095404,-0.011692309,-0.027275888,0.030668776,0.03147998,-0.008262555,0.037103966,0.013759113,-0.020765869,0.0032674924,-0.07309643,-0.018911058,0.07495312,0.012383233,0.056414224,-0.027131667,-0.051362533,0.0037050545,0.024646053,0.030083707,-0.002863619,0.049326085,-0.03574834,0.021514453,-0.049331103,0.030443221,-0.08287275,0.014460554,-0.07709887,0.0072015254,-0.034077045,-0.009816318,0.090501264,-0.001570628,0.010509552,-0.016418312,-0.058482658,0.04780098,-0.0066725207,0.0041893274,-0.02721892,0.072174616,0.08407928,0.041731924,-0.09627851,0.0491745,0.052388396,-0.042680766,0.041179582,0.052312285,0.007751996,0.009122047,-0.08775589,-0.11429014,0.024097385,-0.00027723386,0.03233176,0.031458408,-0.056583222,-0.00979783,0.027625455,-0.021278504,-0.010395445,-0.107381836,-0.060143914,0.03344347,0.0877108,0.0019883243,-0.02997003,0.039182648,-0.026468223,-0.00020438404,-0.018372055,-0.034002963,0.011456651,0.09728251,-0.059412785,-0.13458256,0.054187592,-0.0012861295,-0.028556306,0.104411334,0.06793069,0.020621674,0.032817997,-0.13190679,2.8924361e-33,0.079329304,-0.007724603,0.03010526,-0.09839529,0.010151268,0.024122557,-0.10102598,0.0716967,0.014943269,-0.10152408,-0.07397607,0.018342933,-0.022587681,-0.063200004,0.004407256,0.044546254,-0.055193055,-0.00915289,0.030978728,-0.033650614,0.018413704,0.034477197,0.04426818,0.022102723,0.0683335,-0.014445511,-0.035989247,-0.003870781,0.059562463,0.026822852,-0.030186519,-0.13411091,-0.019578092,0.040063612,0.011521927,0.07124702,-0.083970435,-0.025947617,-0.049259715,0.031149257,0.030129077,0.04671204,0.023745669,-0.030568317,-0.0016931802,-0.062967956,-0.07213713,-0.0126831,0.02331072,0.053453434,0.0334921,-0.042801782,0.06701393,-0.08454857,0.019215172,0.025397027,-0.03579777,0.03784812,0.060801767,0.05647395,0.08098737,0.10487085,-0.045781277,0.066326,0.00020508074,0.03767478,-0.04928983,-0.019182466,-0.019261463,0.08893419,-0.043765977,-0.023841161,0.079144925,0.031805523,0.016809516,-0.08368032,-0.0391178,-0.0021160198,0.030971177,-0.051337644,0.011715571,-0.029579539,0.005807095,-0.020475823,-0.044643532,0.017059177,0.0025259776,-0.005207702,0.023366902,0.0017933553,0.040366594,-0.031827662,-0.043481547,0.014793471,0.00024709746,-2.6914556e-33,0.04903434,-0.11911737,0.026974672,-0.016711013,0.029656582,0.12736519,0.015696017,-0.0704641,0.07949934,-0.032621395,0.13079095,0.0016157342,-0.062699094,-0.0089669805,0.022110276,0.007294326,-0.007846483,0.042460285,-0.034018356,-0.041502412,-0.047611002,-0.02915762,0.06833609,0.035798453,-0.0057067117,0.014569383,-0.076217085,0.015603429,0.076395355,0.051142234,-0.029162252,0.08816635,-0.041607022,-0.08302138,-0.09937356,-0.020323649,-0.046294183,0.011511981,0.0034205166,0.022991998,-0.016911557,-0.0012386583,0.0072954036,0.05468026,0.020602087,0.09118236,0.021076256,0.0108766295,0.047380712,-0.06327577,0.049146287,-0.07226087,-0.024418272,0.0290316,0.020402199,0.037748426,-0.012183705,0.076202966,-0.011127314,-0.049527552,-0.048237335,-0.08767701,0.02072598,-0.006356842,0.039663754,0.03281962,-0.012321835,0.097774215,0.0009268187,0.023975618,0.061440855,-0.05160083,0.03149237,0.039701127,-0.027815154,0.027367793,-0.052834354,0.009587625,0.047950577,0.022093032,0.022704242,0.03303795,-0.07157281,-0.015726095,-0.03420698,-0.045408823,0.00718996,0.06925237,-0.058356643,0.062257808,-0.11678717,0.057025004,0.016545583,-0.016982332,0.06465122,-3.792247e-08,0.04400107,-0.052462846,0.0016350686,-0.010220848,0.09473061,0.040711775,0.0006336636,0.03790328,0.07830789,-0.0005439867,-0.03126303,0.080334865,-0.004976148,-0.048209164,0.018739732,0.054925866,-0.027309414,-0.015487013,0.017309034,0.031624004,-0.08090633,0.038136948,-0.03925601,-0.013323503,-0.03238687,0.0017693879,0.022876887,-0.033368405,-0.03878842,-0.03563115,0.036177136,0.0382199,0.010839288,-0.059792027,-0.080252394,0.00096005254,-0.0011010105,0.0032229982,-0.055235498,0.03155963,0.007190617,0.024322031,-0.11406893,0.0027177867,0.013986124,0.03185645,0.05608546,0.05151548,-0.08949963,-0.040775932,-0.016330393,-0.05419325,-0.012667842,-0.018190853,-0.10984894,0.040389173,0.05407004,-0.14758082,-0.04958056,-0.049918983,0.056038603,-0.02348332,0.18657047,0.07021803 +1.8.1.14,"A flavoprotein. Not identical with EC 1.8.1.6 (cystine reductase), EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.13 (bis-gamma-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1].",384,1.0,-0.04183202,-0.026917087,-0.07897164,-0.02226545,0.023472808,0.034797546,-0.057955135,0.103611484,0.051250793,-0.087405905,-0.0053748298,0.022819705,-0.00017368166,0.027846936,-0.06988701,-0.01288554,-0.005301749,-0.053695474,-0.0116358865,-0.007295451,0.03814217,0.012123294,0.008368459,-0.024953512,0.066207305,-0.0044989963,0.025443869,-0.032989524,-0.08187092,-0.082520775,-0.039587982,-0.02320849,0.05508513,-0.0017525814,0.0032002144,0.047364365,-0.034896106,-0.0036658496,-0.000623761,0.010034144,0.020828405,0.03796809,-0.0029868765,0.007306786,0.010436051,0.00081106543,0.0075661945,0.09747846,0.023003442,0.030087441,-0.050479952,-0.016161792,-0.06131776,0.080647096,0.08441082,-0.031631153,-0.030888183,-0.048193477,-0.03024676,-0.016214816,-0.01371563,-0.055281047,0.07259946,-0.051136065,0.026779387,-0.052369725,0.040146373,-0.074249074,-0.005189626,-0.07140653,-0.08165051,0.0044769254,0.0027191655,0.10270513,0.0018105544,0.08727099,-0.07038415,0.013532096,0.03921062,0.017778264,0.046959694,-0.04044598,-0.06136204,0.10917763,0.11022584,0.008440581,-0.042792734,0.04006642,-0.017609967,0.027815554,0.030104248,0.019043945,0.025455404,0.006962489,-0.12374019,0.01969595,-0.0296545,0.011331093,-0.035170805,-0.065171875,0.0003496456,0.027858863,0.028770445,0.0137689635,-0.05117218,-0.031480905,-0.0071987514,0.07994707,0.02023289,-0.07996078,0.04162968,-0.031838473,-0.01951528,-0.08875459,-0.054149665,0.06759214,0.0115665,-0.021407163,-0.1340756,-0.029939603,-0.010589802,0.04244547,0.047823794,0.010622575,0.026866969,0.0024769066,-0.14545909,4.77201e-33,0.068782106,0.036588784,0.02330096,-0.015656646,0.038752146,0.029039383,-0.09238037,0.06251812,0.055636995,-0.09210273,-0.07113818,-0.029533017,0.04579958,-0.04481691,0.073176,0.070434645,-0.012619256,-0.046390995,0.0055167433,-0.067454115,0.08276248,0.05139651,-0.00849662,0.05389739,0.05590893,-0.045306455,-0.018093573,0.0066990918,-0.009271531,0.014647866,0.0018676553,-0.14207497,-0.07619485,0.02520063,0.04603641,-0.026870146,-0.112926066,-0.084301636,-0.051433954,0.04212572,-0.093859136,0.02656883,0.015978295,-0.0021992752,0.061145708,-0.055177756,-0.068091966,0.08638888,0.038625844,0.0679168,0.042053476,-0.014246539,0.14676122,0.013508106,-0.026644787,0.06762863,0.026896283,0.03338938,-0.004890291,0.10145836,0.040430617,0.11362297,-0.04635665,0.045451574,-0.073651984,0.070199504,-0.05948404,-0.034134462,-0.012058141,0.097997725,0.03906374,0.030977597,0.08515014,0.034756366,-0.019047113,-0.021794578,-0.061527506,-0.013580159,0.021770658,-0.021167062,-0.03061185,-0.046035804,-0.029320404,-0.0061707366,-0.10227902,0.06169121,0.044400595,-0.016891247,0.04255874,0.03845691,0.05299491,-0.03645278,-0.0137255415,-0.030239722,-0.033547472,-3.499445e-33,0.07306315,-0.09396302,0.08635098,-0.05690775,0.04095844,0.048840918,0.05318974,-0.07369773,0.010889668,-0.06575561,0.035202507,0.03356092,-0.007486823,0.0052153342,0.06484908,0.019691648,-0.033404995,0.093526885,0.03876698,-0.0024352258,-0.030408284,0.058516905,0.058145527,0.007646205,0.028233385,-0.05381853,0.015739327,0.03585192,0.047612112,-0.034544833,-0.051400345,0.08394672,-0.015707785,-0.08562995,-0.03844463,0.05638248,-0.038451366,-0.031435,0.030177074,0.055175323,-0.010504992,0.016150992,-0.0406821,0.011004353,0.0876551,0.08020787,-0.06838251,0.06444123,0.0752528,-0.043742895,0.065084934,0.02777925,-0.00073439564,0.040949408,0.059944935,0.007863548,-0.0019162302,0.06238735,-0.005063168,0.018062318,-0.016685484,-0.10845184,0.0135610225,0.021532087,0.008048655,0.03614515,0.042238288,0.06204935,0.0023437445,0.010702243,0.06826857,-0.07710953,0.021907318,0.07444021,-0.035146873,-0.05360598,-0.0636684,0.0780177,0.009257605,0.00097120745,-0.002234792,-0.003478587,0.0040991902,0.030647991,0.00088506186,-0.011652898,0.010236717,0.020008124,0.006565544,0.027002027,-0.072995596,0.046293568,-0.012213027,-0.019098869,0.018911103,-4.524107e-08,0.11018162,-0.0293939,0.0156553,-0.016844979,0.09345476,-0.0113295205,-0.027656382,0.00025213303,0.01254343,0.03867449,-0.0076568774,0.103607155,-0.02279888,-0.05853034,-0.0022586747,-0.0076642036,-0.043089844,-0.05491523,0.011925913,0.029760819,-0.042853467,-0.0031589784,-0.121560015,0.04285225,-0.010123314,-0.031660922,-0.011489348,-0.031235173,0.03039117,-0.071307816,0.06669273,-0.0013589773,0.04116666,-0.0730522,-0.13072535,-0.046539947,-0.06639087,0.030713618,0.019726504,0.08091182,-0.0081515685,-0.061551478,-0.02639094,0.026822874,-0.0057605505,-0.023389626,0.030420534,-0.04114947,-0.043882623,-0.024284746,-0.00044741802,-0.020629967,-0.0004654038,-0.03241846,-0.06647336,0.008276882,-0.007488243,-0.06916729,-0.0291601,-0.05817652,0.088075325,-0.0014913675,0.14589882,0.03409012 +1.8.1.15,"Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate.",384,1.0,0.015133587,-0.066787615,-0.04283193,-0.017960925,0.07046724,0.035096385,-0.009303159,0.04944145,-0.051128954,0.004670519,0.09972105,-0.08091354,-0.04990109,0.083101615,-0.042527966,-0.04591431,0.036691427,-0.02892277,-0.025097482,-0.049796373,0.0065618367,0.027400339,0.05830148,-0.0144445235,-0.0074350582,0.015810708,0.015371402,-0.040465824,0.042526104,-0.0018296504,-0.08025234,0.016454315,0.017459124,-0.008929203,0.02257176,0.050774,0.0037703246,-0.022082537,0.02295529,-0.009765223,0.015509129,-0.029338373,0.04199001,-0.039074954,0.06134636,0.00788971,-0.044574387,-0.04180881,-0.014797222,0.014739057,-0.01707885,-0.06984678,0.003162353,0.039783537,0.02340574,0.034454156,0.0103387665,-0.051888533,-0.013937084,0.078072436,0.0045385254,-0.03776525,-0.024362933,-0.0523632,0.043668326,0.0073077506,-0.057521917,-0.008613619,0.009625638,-0.051577523,0.052512355,-0.074502066,-0.015525777,0.023450151,-0.032927796,0.029213835,-0.012976475,-0.098892756,0.07002136,-0.0085372655,0.005398518,-0.01957248,0.09825036,0.12150799,0.05334188,-0.006374815,-0.025556494,0.04074084,-0.032250937,0.0047638956,-0.019117283,0.033360817,-0.07393103,-0.03970849,-0.08447631,0.07717951,-0.051445883,-0.0101570515,-0.07624289,-0.01261648,-0.0029583997,-0.022683237,-0.00198939,-0.03668322,-0.11295217,-0.006868494,0.004332302,0.062419184,0.024865888,-0.020681893,-0.054359045,0.018551014,0.027398963,-0.031707995,-0.054248445,0.0044647935,0.10372072,-0.05886789,-0.06632529,-0.020307075,0.012454968,0.057504375,0.10716372,0.04521843,0.012100975,-0.044109467,-0.0019141306,3.572307e-33,0.08167369,-0.019996217,-0.012224782,-0.009151465,-0.011096166,0.047945157,-0.058210842,0.006110684,0.054277092,-0.080732726,-0.09554942,-0.014322676,-0.02662499,0.026976988,0.03911285,0.0038683405,-0.01658371,-0.044931162,0.12453045,-0.082332924,0.029851655,0.044699974,-0.008296868,-0.014247893,0.015503655,-0.07372401,-0.05938674,0.0182786,-0.0040348377,-0.014390299,-0.02773049,-0.028878398,-0.040223747,-0.009520791,-0.010331225,0.051904462,-0.08455197,-0.029940281,-0.11050391,0.025119895,0.052206803,0.02638307,-0.005143016,-0.014697366,0.049086858,-0.08006737,-0.043450665,0.048908263,0.048157845,0.12608095,0.06326369,-0.026590642,0.022170082,0.0093581835,-0.051342133,0.018401595,-0.05446716,0.023244135,0.046166915,0.06639207,0.026025988,0.054554038,-0.08886777,0.07138745,-0.053315587,0.0382476,-0.07287485,-0.01856464,-0.05294718,0.04425042,0.019632736,-0.053872816,0.04906273,0.056495607,0.051590115,-0.0779968,-0.005873275,0.0178167,-0.012736782,-0.03499042,0.04761505,-0.06982281,-0.002863212,0.032704964,-0.118380554,0.045199946,0.012529454,-0.051854365,0.074451864,-0.051044304,0.05117963,-0.05568434,-0.049728923,0.04337963,0.043133557,-3.638998e-33,0.054539155,-0.08795597,0.085285656,-0.066063136,0.026116136,0.04533693,0.060191598,-0.054168586,0.095935725,-0.047380697,0.110513456,-0.038837798,-0.061511222,-0.03944933,-0.0009965124,0.05118419,-0.027590718,0.07969888,0.048160043,0.011897832,-0.07475569,0.06817612,0.031527575,0.05758598,0.10436629,0.044809714,0.026793864,0.0019910934,0.02654946,0.05279305,0.0629194,0.010239701,-0.07609485,-0.016067382,-0.034054957,0.0034687128,0.006156509,-0.037133414,-0.062352963,-0.028400285,-0.015026531,0.047358632,0.010953256,0.151597,0.02070192,0.06514627,-0.100130774,-0.038697932,-0.01807944,-0.056569688,0.03008594,-0.037198186,-0.023230199,-0.035128865,0.09602437,0.0054481956,0.037251037,-0.0034848165,-0.058661748,-0.049629714,0.02616084,-0.041969366,-0.050936777,-0.07086272,0.12287812,0.04216511,-0.013105348,0.08581559,0.020960502,0.07497589,0.09618364,0.038018264,0.028584665,0.012122769,-0.03218372,0.004350791,-0.028215637,-0.007180512,0.0023784707,0.0034305563,0.061249603,0.01847819,-0.02431069,0.0051516066,-0.065201156,-0.060691256,-0.04217102,0.0440153,0.0023729561,0.04982659,-0.045725938,0.047583558,0.04621654,0.038248237,0.084489375,-2.646246e-08,0.056799337,-0.04811057,-0.009320925,-0.080517866,-0.014308332,0.013063064,0.058607828,-0.0069284653,0.025664946,0.015737066,-0.07022077,0.122992314,-0.03005671,-0.014960304,-0.019135552,-0.049850125,0.034158558,0.040296428,-0.02415188,-0.0041725105,-0.13480772,0.06846949,-0.05621117,-0.053949356,-0.088111766,-0.037640754,0.07236331,0.017928759,0.034446232,-0.019670617,0.016628863,-0.04150499,0.043802265,-0.06575559,-0.042266447,0.06841098,0.07250909,-0.023355968,-0.088152856,-0.0023077552,0.0005549735,0.006990053,0.010510983,-0.022047382,-0.00033506015,-0.062067218,-0.0043604006,-0.036842383,-0.002197039,-0.025806705,0.06192814,-0.010643598,-0.013660422,-0.035040516,-0.14878248,-0.04669013,-0.018813197,-0.0670269,0.009392929,-0.08942818,0.048668347,-0.019199599,0.16348031,0.08048763 +1.8.2.1,"Associated with cytochrome c-551. The enzyme from the bacterium Starkeya novella contains a molybdopyranopterin cofactor and a smaller monoheme cytochrome c subunit. cf. EC 1.8.5.6, sulfite dehydrogenase (quinone).",384,1.0,-0.10296563,0.0031936981,-0.10167013,-0.0011160923,0.013535974,0.057353873,-0.11509928,0.059887912,-0.0296987,-0.03079175,0.026341464,-0.0978741,-0.016973302,0.022963064,-0.07161166,0.038360685,-0.054049697,-0.050981708,0.012239086,-0.0014431837,-0.05926052,0.025587,0.012983861,-0.014423303,0.03825175,-0.014781521,-0.020798298,-0.0020682442,-0.098700754,0.03117545,0.024618113,-0.023466105,0.06620819,0.0037193352,0.09702681,0.067909844,0.010245593,-0.05672195,0.11272452,0.046141256,-0.0021950186,0.08640651,-0.023707759,0.043996148,-0.03419738,-0.013435584,0.013723627,0.030050507,0.0487801,-0.0017358843,-0.04194321,-0.033010088,-0.041223966,0.053254392,0.029550606,0.03243799,6.402011e-05,-0.06653983,0.0631816,0.022752538,0.01399557,0.01300729,0.10830954,-0.009832443,0.044673763,-0.09011262,0.06667008,-0.067007676,0.061782617,-0.111977965,-0.07379642,-0.04754221,0.0225085,0.023922704,-0.060060363,0.040376484,-0.018581778,-0.006011539,0.05860022,-0.09532495,-0.031933803,-0.019072779,0.009214921,0.10334776,0.045560926,-0.08433617,0.045562815,-0.024303773,0.021792656,-0.011819812,0.010365732,-0.03558948,-0.008753252,-0.077904,-0.06343236,-0.02696225,0.06917085,0.08955481,-0.049552705,-0.01008762,0.026937459,0.010039597,0.04019673,-0.06833955,-0.07675083,-0.034278188,-0.0142073445,0.10900591,-0.008044362,-0.03508192,-0.019977087,0.041525226,0.009937645,-0.032258887,0.050651845,0.056176417,0.07054888,-0.016440397,-0.017382963,0.060941994,-0.009072861,-0.037227783,0.02554703,0.015473887,-0.03977344,0.076182984,-0.09133976,3.256306e-33,0.10850234,0.07104772,0.04234361,-0.026671099,0.01180448,-0.0352751,-0.0649346,0.06799506,-0.044095024,-0.04733603,-0.055299934,-0.03403259,0.04803644,-0.04131047,-0.1070763,0.055871308,-0.05478164,-0.07618514,0.036849868,-0.033160772,-0.017186377,0.06155209,0.0041523613,-0.07449497,0.04390857,0.020712309,-0.03095085,-0.00052606926,0.014254631,0.015509842,-0.03636384,-0.080915466,-0.07947294,-0.023877257,0.088157274,-0.068297826,-0.033857215,-0.081901,-0.061312493,0.05257839,-0.057414524,0.059370857,0.029343886,-0.09518667,0.04689075,-0.0053843493,-0.0604202,0.05562156,0.019204149,0.054659404,-0.012832251,-0.056903593,0.06103175,-0.007282091,-0.08774886,-0.011786459,0.015908284,-0.0011810438,0.06871188,0.06277542,0.06295372,0.08035056,-0.011685962,0.031577926,0.060468834,-0.016319698,-0.07386898,-0.0037507166,-0.006055964,0.10276161,-0.08249602,-0.036302827,0.049807232,-0.003361036,-0.02687867,-0.07062533,0.006895208,-0.042983845,0.004905542,-0.008029641,-0.015482747,-0.05490294,-0.0043157986,-0.06953953,-0.0466525,0.005941045,-0.051844735,-0.08814977,-0.05347441,0.022589056,0.014150519,-0.04269737,-0.036991905,-0.00573995,-0.01753529,-4.051735e-33,0.073982336,-0.069454,0.030269597,-0.14949591,-0.028573524,0.12901504,0.014897915,-0.03209309,-0.035784088,-0.014343759,0.09892188,-0.031393617,0.01853299,-0.049287938,0.025475493,0.022106562,0.0050207884,0.072232865,0.044152703,0.048202455,0.0055318777,-0.067507125,0.0041415244,-0.002922702,0.072657615,0.044299453,-0.020372938,0.038359486,0.06977346,0.0010358652,-0.0210294,0.07838763,-0.034921456,-0.06952027,-0.039004587,0.020861687,-0.04653603,-0.020481735,0.07795962,-0.0011578606,-0.0035842068,-0.012159475,0.07122997,0.16398951,0.009328845,0.04172888,-0.07750362,0.016542112,-0.01047333,0.0051027024,0.003602016,-0.04866761,-0.029531317,0.02720998,-0.009268046,0.086449996,0.017595386,0.0262218,0.017419802,-0.0029173992,0.017036384,-0.023502164,-0.03884645,0.05154446,0.05275419,0.03882276,-0.05174953,0.06152356,0.05398081,-0.012649606,0.04752393,-0.009224509,0.004861833,0.011900793,-0.036416974,0.004616405,-0.03427725,0.018895617,0.008452464,0.033001024,0.06975906,0.024746692,-0.0017334529,-0.029794492,0.01875008,-0.04668157,0.014432651,0.092865296,0.013266742,0.0054826844,-0.03779993,0.011009122,-0.08788928,0.04432945,0.03671523,-3.5561214e-08,0.07972235,-0.06963798,0.054089945,-0.017598554,0.01351103,0.054647587,-0.007162364,-0.013280921,-0.044560608,0.022720017,0.087581865,0.059413195,0.0027427876,-0.0336447,0.005091203,0.05984545,-0.06688788,0.0053400677,0.00054128875,0.106167085,0.024365338,-0.050556716,-0.048745252,0.070796154,-0.008071943,-0.08096033,0.01033871,0.06775141,-0.053065,-0.018583879,-0.026061246,-0.015145277,0.002862539,-0.033152107,-0.030069036,0.021799069,-0.036732372,-0.07499042,-0.07031553,-0.037889652,0.008365776,0.036716655,-0.1078072,-0.00015825042,0.08215702,-0.0024667613,0.017221715,0.040433656,-0.034925885,0.039325465,-0.0017592558,-0.031673547,0.031801905,-0.01154329,-0.12117797,0.024014575,0.011181672,-0.08883758,-0.023272905,-0.044444107,0.04772371,-0.02391512,0.15181905,0.0075140633 +1.8.2.2,"The enzyme catalyses the reversible formation of a sulfur-sulfur bond between the sulfane atoms of two thiosulfate molecules, yielding tetrathionate and releasing two electrons. In many bacterial species the enzyme is a diheme c-type cytochrome. In a number of organisms, including Thiomonas intermedia and Sideroxydans lithotrophicus, a second diheme cytochrome (TsdB) acts as the electron acceptor. However, some organisms, such as Allochromatium vinosum, lack TsdB. The electron acceptor in these organisms may be the high-potential iron-sulfur protein (HiPIP).",384,1.0,-0.079747096,-0.043561403,-0.102063335,0.0073431414,-0.023744447,0.002506632,-0.033182308,0.09660914,0.01702222,0.020101897,0.010857251,-0.033659536,-0.069243036,0.018641494,-0.005050765,0.04472955,-0.06528405,-0.016267255,0.055767007,-0.017414983,-0.0029436438,0.00063184585,-0.050525397,-0.05523668,-0.0274245,0.08426588,-0.008643483,0.04206008,-0.06975753,-0.007603261,-0.017632365,-0.0014654805,0.006218004,-0.010268241,0.021699019,0.08702152,-0.0972591,-0.059988886,0.009857433,-0.049963884,0.038666897,0.0086266445,-0.08299097,-0.051595483,-0.028616872,-0.05336051,0.0061934697,0.046674166,0.055882715,-0.06286862,-0.024138905,-0.01802082,-0.020889228,0.09941092,-0.028729325,0.006173037,-0.0067797913,-0.051174644,0.0061827786,-0.05795741,-0.041197613,0.021983292,0.011101918,0.017121753,0.086194836,-0.030842803,-0.030503476,-0.013339418,0.0328251,-0.036666475,-0.042608645,-0.054055855,-0.0400006,0.016532602,-0.014828042,0.046312287,0.02819074,-0.05004883,0.028739935,-0.006977724,-0.058753137,-0.054779105,-0.012952781,0.09124872,0.072128035,0.00033550413,0.018686987,0.025497172,-0.008121496,0.058114115,0.038149945,0.0538511,0.009849489,-0.10212248,-0.048445676,0.01831098,0.027942635,0.016010499,0.010631532,-0.038718924,0.012690816,0.0691503,-0.01725183,-0.0944862,0.016585223,0.006095165,0.03565145,0.07173105,0.017704254,-0.010648983,0.014623785,-0.012059305,0.05977674,0.01582145,-0.044371374,0.095557764,0.046915106,-0.07148644,-0.053050306,-0.013373529,-0.026923545,-0.012028033,-0.015574114,0.013108272,0.019352106,0.030831993,-0.14323384,1.8279009e-33,0.08279998,0.044197157,-0.01120417,-0.10620541,-0.007431296,0.031922717,-0.07908728,0.042765453,-0.056275107,0.06909445,-0.06733412,-0.0371491,0.07981274,-0.01423142,-0.0057391487,-0.0018822708,-0.05971888,0.07258882,0.06426399,0.022612536,-0.00693049,0.01801241,-0.008169679,-0.049382254,0.002945883,0.09623774,-0.04125433,0.01142681,-0.034916732,0.033540905,0.028577253,-0.076403834,-0.08863302,-0.0029137982,0.13499361,-0.025296748,-0.017819688,0.009411609,-0.018476108,-0.023655118,0.0024703038,0.014398808,-0.000489582,-0.02965201,0.04249788,-0.0770038,-0.07478613,0.005535215,0.0069208364,0.031035278,-0.01962475,-0.06755456,0.06436336,-0.04157339,-0.044410594,0.039585434,0.048787586,0.04869159,0.054808117,0.08077614,0.0030494363,0.120869905,-0.08423258,0.023479372,0.033328623,-0.009358837,-0.039304566,-0.022843562,-0.030193884,0.10836019,-0.047019847,-0.019949177,0.036053836,-0.018742714,0.03665638,-0.020283585,-0.011472255,-0.029273462,0.087902784,0.027191048,-0.0017980022,-0.117194496,-0.012394921,-0.046302393,-0.056246456,-0.025438864,-0.029099824,-0.07821704,-0.04744428,0.0010448279,0.0437454,-0.045707107,-0.07689989,-0.04840262,-0.027979696,-4.2148463e-33,0.05485449,-0.03288367,0.026310362,-0.06331464,-0.026888458,0.056474652,-0.022743678,-0.016433358,0.023189805,0.041056868,0.1527388,0.003493229,0.037768714,-0.08148303,0.023891725,0.052254263,0.032030188,0.0026138076,-0.010895713,-0.0369366,-0.0030807073,0.04377636,0.041021693,0.05380997,0.021628283,0.014016621,0.015030736,-0.0005783663,0.09575717,0.058369804,-0.029857958,0.04850654,-0.01797988,-0.080525585,0.019225292,0.038943257,-0.056269493,0.012978549,0.11912336,0.043739803,0.054700516,-0.027310323,0.059385452,0.08054194,0.013849692,0.035761192,-0.09833089,0.090980045,0.010050283,-0.03908301,0.07411295,0.010794011,0.045238435,0.03909532,0.015628431,0.042714145,0.037207905,-0.027372949,-0.062110286,-0.029570777,0.013682197,-0.08808712,0.026041873,-0.0072795604,-0.0018261899,0.006538528,-0.08931594,-0.02284522,-0.021082293,-0.039272763,0.047240727,0.004093908,0.019913882,-0.05672636,-0.030925361,-0.0062466706,-0.05007247,-0.023744112,0.062639624,-0.014200449,0.0024926835,0.0921444,0.030061975,-0.086817615,0.060693946,-0.108029425,-0.093977965,0.09521877,-0.03281318,0.006896727,-0.036517352,-0.019000497,-0.033706855,0.0483306,0.038588673,-4.2350436e-08,-0.026082385,-0.09322376,0.046412073,-0.0047362517,0.007607906,0.0035403483,-0.006707034,-0.034085155,0.059134558,0.01740029,0.04430235,0.14666,-0.0376009,0.022845846,0.09932893,0.08834269,-0.04295902,-0.07899349,-0.025141103,-0.0025170331,-0.01709542,-0.05178356,-0.050163064,-0.013366159,0.017228365,-0.0285451,-0.003557338,-0.055017304,-0.035867184,-0.026570302,0.04418407,0.04157444,-0.041771125,0.03016058,-0.020788113,0.010416452,-0.056683443,-0.09141413,-0.03106814,0.0055004605,-0.008765543,0.046784494,-0.13738137,0.045157507,-0.035473146,0.0026234523,0.04970032,0.1066252,-0.04464326,-0.03387065,0.017376412,-0.030519847,0.04721747,-0.09466996,-0.066218935,0.07623085,0.045451507,-0.08299736,0.032130513,0.0008025113,0.12630484,-0.020969233,0.17701308,0.0061706784 +1.8.3.1,A molybdohemoprotein.,384,1.0,-0.04025757,-0.020429708,-0.054259907,0.047124024,-0.029078135,-0.08115993,0.039314643,0.060184192,0.00023576434,-0.084457174,0.027200615,0.0072845127,0.013476607,0.022458013,-0.08416375,0.0745026,-0.008594451,-0.05809613,0.008687192,0.08751288,-0.06782315,0.080406405,0.017025065,-0.013238459,-0.0066179894,0.0174287,-0.00568857,-0.014675186,-0.021536617,-0.028767414,0.052188694,0.11013188,0.04235798,-0.009248329,0.066497,0.021419454,0.024336142,0.011719135,-0.0130583495,0.028571827,0.0328244,-0.021843756,0.039483517,-0.004104773,-0.010488694,0.023229389,0.04703805,0.051434927,0.0017630827,0.06071058,-0.027185753,-0.13913296,-0.1129153,0.04817217,0.028719502,-0.022144333,-0.012972364,0.05803435,-0.005419994,0.018069187,-0.061995655,0.065261476,0.10917685,0.023286598,0.052805386,-0.07955556,0.0760577,-0.06930042,0.046473708,-0.017708061,0.033374928,0.013515421,0.025834072,0.06017411,-0.03987243,0.052930422,-0.000104210245,-0.059926145,0.1683743,-0.05138454,0.013171112,0.0030806325,0.0158261,0.018080315,0.051985614,0.013907245,-0.0012840563,0.020569773,-0.075736314,-0.019980913,-0.056422442,-0.06654799,-0.008565386,-0.0030382557,-0.10187181,0.013747104,0.050549332,-0.07878322,-0.1309173,0.061709393,-0.031162782,-0.0023240754,0.06432858,0.014881374,-0.04619702,-0.017719056,-0.012054278,-0.013555144,-0.027281644,-0.022479875,-0.002992153,0.040030174,0.079629116,-0.012066383,0.054043636,-0.015819604,0.0037859823,0.061971236,-0.02122637,0.026620978,-0.03007751,0.042202502,-0.030844845,-0.0004821455,-0.05018581,0.08347785,-0.0114859585,-7.0232633e-34,0.1085772,0.0042322217,0.07614793,0.013488706,-0.03951775,0.037174035,-0.04534484,-0.0074805706,-0.028577974,-0.08400609,0.011307914,-0.05665415,0.06561211,0.04789324,0.058238048,-0.013899955,-0.062075656,-0.0067968206,0.04929436,-0.059048895,-0.07117732,0.072159015,-0.03404565,0.015578541,-0.01252115,0.029381284,-0.031311132,-0.055611905,0.05060476,0.053708125,0.0033507773,-0.009831575,-0.10171631,-0.04114292,-0.030171806,-0.012759931,-0.053155743,-0.103380874,-0.062007055,0.001490826,-0.06635675,-0.021682426,-0.09356826,-0.050595783,-0.009023501,0.017538384,-0.032828048,0.06672678,-0.023202833,-0.011291842,-0.005456909,-0.07627699,0.068863995,0.016823864,-0.10009198,0.016388515,-0.002068963,-0.05671882,-0.011823793,0.011412408,0.03655159,0.08872112,-0.012229069,0.041008368,-0.07521982,-0.085377365,-0.10042862,-0.061168283,-0.013436405,0.057708997,0.05309778,0.02654892,0.08435317,0.012661717,-0.07397851,-0.015910912,0.079350896,-0.030834543,-0.048653822,0.015986348,0.0010791125,-0.0233846,0.05301185,-0.101445556,0.0034304555,0.052841663,-0.00877915,-0.04408699,-0.056587704,0.029553909,0.034175996,-0.00036133965,-0.07072857,-0.083978444,-0.057226524,-4.347411e-34,0.022345463,-0.092354365,0.047413938,0.008495882,-0.0076751136,-0.009422192,-0.019483574,0.021519922,-0.069798365,-0.065598965,-0.0042842743,-0.045364298,0.05435496,-0.0887552,0.08979841,0.020728067,-0.029032305,0.041718036,0.07539013,0.00839556,0.023490973,-0.07161237,-0.0069146245,0.052104637,-0.00010284412,0.020124821,-0.02467494,-0.06786469,-0.023126828,0.059863064,-0.017931947,0.034284253,-0.08609268,-0.07932597,-0.00462898,0.03979796,-0.03665629,-0.0455577,-0.0025023788,-0.036543854,-0.071474284,0.05170412,0.08410588,0.09629447,0.07355531,0.08281242,-0.0070326724,0.047532994,0.12299536,-0.0035586213,-0.068165764,0.030419517,-0.0066671344,0.06970249,-0.011651121,0.032629345,-0.004125916,-0.013411686,0.013308049,0.01154367,-0.01175519,-0.03248667,-0.07891644,0.046289302,0.025582356,0.1416998,0.032043356,0.014735338,0.04900878,-0.059729647,0.062232055,-0.0071731745,0.040791355,0.019512089,0.0210806,-0.03138716,-0.085265785,0.052823722,-0.020449314,0.02003042,-0.02043369,0.0008532868,0.036413625,0.0037941143,0.028395994,-0.10615459,-0.025067177,0.10053536,0.041469797,0.00048852566,-0.05622133,0.053285114,-0.11235002,-0.048273813,0.08099969,-1.8149104e-08,0.022823162,-0.12169214,0.022913884,-0.0986407,0.021698505,0.09543579,0.002425705,0.017148836,0.034414396,-0.014132373,0.0635684,0.020430012,-0.03716054,-0.01284421,0.04234751,0.03601847,0.004733347,-0.01369089,-0.03234967,-0.017807785,-0.007600523,-0.031416308,0.001948522,0.118014626,-0.058859125,0.027271004,-0.00739881,0.03751992,-0.040967144,0.010520695,0.019699985,0.045231987,-0.04661021,-0.054531664,-0.06444206,0.033069145,0.051336855,-0.017640747,-0.014460615,0.041590936,-0.02291928,-0.04362986,0.02052375,0.0031204072,0.08781664,-0.03827754,0.050015435,-0.0026790504,0.0014453146,-0.05764656,-0.038879972,-0.0054349205,-0.012763127,0.063346244,-0.098388694,-0.015584945,-0.021916103,-0.04804494,-0.06800709,-0.03640819,0.01210494,0.03320666,0.112289526,0.04993899 +1.8.3.2,"R may be =S or =O, or a variety of other groups. The enzyme is not specific for R'.",384,1.0,-0.0356562,-0.07263631,-0.11431641,0.036772616,0.08820401,0.0037754693,-0.013932392,0.05603694,-0.022811344,-0.0005876895,0.036148783,0.003720801,-0.034820933,0.06926855,-0.03285886,-0.005434908,-0.052211717,0.030618783,-0.027722446,-0.032784846,0.054650526,0.03965383,-0.00022133741,0.0528296,0.07952138,0.04006847,0.008510378,-0.040416364,0.03705915,-0.039169177,-0.006116839,0.012217434,0.09761107,-0.032840602,0.0012308547,0.021827966,-0.03631146,-0.053535253,0.05679,0.041789845,0.015336754,0.021891523,0.054483533,-0.0068220524,-0.032794904,-0.021685032,-0.012913558,0.0397474,-0.010611318,0.038416874,-0.009003436,-0.09212551,-0.1155266,0.05053977,0.030169956,0.015518135,-0.10594443,-0.09782617,-0.11404573,-0.04709244,0.046627156,-0.0859862,0.03711103,0.056517836,0.025885487,0.02157449,0.05074395,-0.011730385,0.027693568,-0.019417817,-0.062525764,-0.07561513,-0.05595129,0.02227194,0.007929741,0.013044405,0.10094522,-0.0022431843,0.07103171,0.012395264,0.013137976,-0.013213506,-0.04352102,0.07458839,-0.009487206,0.074317545,0.057808764,-0.015892068,0.011340895,0.02955005,0.03138161,-0.007953128,-0.026787296,-0.07795335,-0.042109113,0.003466824,0.0152953565,0.032809075,-0.016743418,-0.04367354,0.018706318,0.016165428,0.0024864902,-0.009059188,-0.14773653,-0.014603009,-0.030814402,0.02989018,-0.0027356374,-0.02140491,-0.005232219,-0.008970402,0.024507593,0.02905548,-0.055022825,-0.009424926,-0.0009018157,-0.028477522,-0.048698734,0.060317706,0.007102655,-0.0032507526,0.017601844,0.028769406,-0.021217993,0.0134802675,-0.11647689,-2.7780576e-33,0.01534729,0.05891637,0.03033542,-0.09272927,-0.011721444,0.000426685,-0.115293786,0.08079078,-0.07579594,0.0006796931,-0.096595146,-0.087547876,0.052937347,-0.055445272,-0.050292965,0.064559296,0.045897312,-0.0075245365,-0.022055311,0.02859044,0.026925055,0.12017879,-0.08747405,0.05350961,-0.033802275,-0.0023716686,-0.009556486,-0.045840014,0.04601469,-0.02526867,0.01043696,-0.034578804,-0.055957314,0.08723446,0.02398583,0.0005572303,0.044286262,-0.021770256,0.048527308,0.053359568,0.055945147,0.01876448,-0.010229648,0.03190067,0.047202192,-0.06686309,-0.07987745,0.06244905,0.036827426,0.09611947,-0.029528597,0.022024525,0.11444412,-0.020029476,-0.00094459194,0.020880615,-0.074496895,0.12406469,0.024450932,0.031781957,-0.070299834,0.049444955,0.010510137,-0.012128705,-0.042893097,-0.009765182,-0.06208246,-0.07724031,0.031331547,0.13352503,-0.012405939,-0.061584115,0.029192932,0.11060685,0.041882653,-0.023285415,-0.024351537,0.026949065,0.08980605,0.06932221,-0.10342296,0.035380546,-0.0046238904,-0.030223833,-0.05757386,-0.08223307,-0.01519465,-0.05287696,-0.048846822,-0.020637693,0.04496006,-0.050191183,-0.049496353,-0.0058739074,-0.019647222,-3.4742374e-34,0.05566574,-0.044071946,0.00078690343,-0.0053061256,-0.008730221,0.0010229961,0.006549197,-0.027672336,0.10075736,-0.013422112,0.0893496,0.009433034,-0.04972981,-0.017519152,0.07101468,-0.018368818,-0.03647519,0.075339876,-0.03155802,0.054477554,-0.097844675,0.07746252,0.06257373,0.020526152,0.054058235,0.015479866,0.0034510859,0.06830604,0.01031789,0.011845609,-0.024447454,-0.036160495,-0.06488015,0.039209086,-0.08343537,0.09715497,0.00687652,-0.0033998182,-0.064670704,0.028756613,-0.025329838,0.042213313,0.055054236,0.072326615,0.043801922,-0.019409677,-0.04474049,0.020788487,-0.007208195,-0.050710887,0.0018447442,-0.043359555,-0.011850707,-0.0017614576,0.03270726,0.026889652,-0.05941858,0.037662927,-0.04701733,-0.053699262,0.012759486,-0.084795505,-0.021933267,0.019330455,-0.059361096,0.0006802737,-0.009676441,-0.008527293,0.04281715,-0.061760627,0.07916439,0.030374328,0.02206998,0.011392185,-0.005875024,-0.055687953,-0.07160386,-0.03128255,-0.0005901247,-0.06155449,-0.02336206,0.030934857,0.026934655,0.005188016,-0.038970415,-0.079016946,0.031910706,0.10376968,0.054595422,0.02127082,-0.018721335,-0.0023065917,-0.056897443,0.06820976,0.099044554,-2.6821033e-08,0.076201506,-0.073400855,0.021595428,-0.06742032,0.085031144,0.052236073,-0.0115667805,-0.09671882,0.018105308,0.03960569,-0.040329702,0.060597487,0.005244147,-0.046537112,0.044208866,-0.017921045,-0.045533776,0.054039586,-0.03732331,0.012659811,-0.046893172,0.00981218,-0.049792018,0.016310448,0.005340111,-0.021445416,-0.00015039643,0.0019361344,-0.019711029,-0.076054655,0.057497524,-0.02772894,0.05144568,-0.0019824172,-0.07939191,-0.03729711,0.05879735,0.04114161,0.028599136,0.08498203,-0.052639477,-0.043001294,-0.013621056,0.03203806,-0.036976874,-0.016694559,-0.014120109,0.034166656,-0.0021127812,-0.1062941,0.07624922,-0.041435488,-0.13838536,-0.06320708,-0.054919712,-0.027181549,-0.016041419,-0.011887016,-0.046719722,-0.08289536,-0.0020913898,0.06617814,0.16225998,-0.08779509 +1.8.3.3,"A flavoprotein (FAD). Also acts, more slowly, on L-cysteine and several other thiols.",384,0.99999994,-0.012359131,-0.10271031,-0.06702761,0.049940214,0.13797125,0.016093625,0.0031974555,0.09512332,0.083625756,-0.037029415,0.033562124,0.040837165,-0.05500948,-0.00863853,-0.066232815,0.009010147,-0.037379336,-0.01614959,-0.091838144,-0.036475033,-0.03638341,-0.004372225,0.008981475,0.0012024242,-0.009604829,-0.031783618,0.007360666,-0.02104564,-0.04283439,-0.018070137,-0.0077091265,0.06855588,0.066531785,0.046568725,-0.07507603,0.06878517,-0.00065679057,-0.010663037,0.0036131039,-0.039383814,0.053850066,-0.07898865,0.029010264,0.009682818,0.04507039,0.021397697,-0.034984637,0.09501859,-0.015785063,0.07964716,0.0009973071,-0.05921095,-0.088914126,0.082320206,-0.04354681,0.059180755,-0.07043676,0.0025792837,0.0022579269,0.026075214,-0.039320175,-0.0033068855,0.033342145,0.03769012,0.07118475,-0.05893162,-0.009791571,-0.003334691,0.039184686,-0.012848357,0.073435575,0.021591756,-0.06981162,0.061077006,0.041781474,0.020844724,-0.08445927,-0.044243433,0.043454845,-0.02212345,0.083728865,0.048724163,0.038789254,0.068803415,0.050375983,-0.070741884,-0.007974323,0.020277688,-0.09521908,0.038482554,0.017303504,0.05154071,-0.04952276,0.0069990475,-0.07535402,0.05139783,0.091918126,-0.038311377,-0.08885369,-0.035042092,-0.043560307,-0.0054980605,0.0372968,0.023538204,-0.08308797,-0.06489182,-0.031813767,0.021797996,-0.06724575,-0.07047307,0.023409398,-0.049249135,0.05144353,-0.07784963,-0.008786305,0.042265728,-0.008310253,-0.0139961075,-0.03834823,-0.0143344095,-0.031742472,0.09586609,0.01624169,0.061319914,0.0007049335,0.009667409,-0.072954945,3.5285732e-34,0.08246977,-0.02265722,-0.039779827,0.0073232353,0.04120224,0.008831959,-0.029982118,0.028422745,0.02880558,0.000996844,0.0009992538,-0.027859805,0.0018466164,-0.070977956,0.025485612,-0.042509638,-0.04801402,-0.04132252,0.054354988,-0.09265468,0.011313667,0.06389411,-0.023731072,0.04222367,0.0091542015,-0.028015714,-0.039969184,0.019037848,0.004571391,0.038320232,-0.035598673,-0.01470583,-0.03634759,-0.039709516,-0.0020498505,0.025362948,-0.046926614,-0.07836855,-0.075195014,0.034755863,-0.016783737,-0.01628719,-0.04517114,-0.032719605,-0.017806137,-0.06308177,-0.09645029,0.07013128,-0.023418568,0.0905093,0.10223124,-0.09688537,0.11775347,0.049020343,-0.06720978,-0.0018196219,-0.029177146,-0.008711925,-0.048353143,0.036992136,0.058493733,0.0538548,-0.04567978,0.119324334,-0.09375446,-0.0010268508,-0.09652253,-0.05807041,-0.018810349,0.11501702,0.053361364,-0.009059177,0.1149317,-0.0362282,0.048412584,-0.0026234442,-0.049424097,-0.013387538,-0.017825913,0.015457027,-0.032329205,-0.035395462,-0.024269126,0.023577722,-0.02273081,0.009346037,0.01565404,-0.03326414,-0.0036050747,-0.03770422,0.016719043,-0.054847848,-0.0019528053,0.003558765,0.044960745,-9.218557e-34,0.045667194,-0.123201385,0.065514766,0.08455439,0.048876613,0.041705377,0.0075367684,-0.031077871,0.037967976,-0.050168112,0.020468969,-0.08207059,-0.06301999,0.013048926,0.049347177,0.029812332,-0.01986967,0.038805384,0.016647058,0.059842903,-0.093142316,-0.043097835,0.07850768,0.07946382,0.06283278,-0.027757432,0.021360345,-0.020480726,-0.005368425,0.060624372,-0.04225903,0.031785585,-0.06560827,-0.07175499,-0.053436097,0.08159474,0.0123881055,-0.03582561,0.0074718,0.008332972,-0.026852569,-0.007327349,0.07196561,0.06163756,0.060591433,0.07696739,0.0039022593,0.044723865,0.01552512,-0.025545545,0.03021179,0.011379112,-0.023724884,0.132864,0.03735416,0.044732813,0.017789615,0.025762806,-0.023778701,-0.031970616,0.0024192904,-0.12159165,-0.053294964,0.0008548803,0.069004595,0.019073522,-0.00074332143,0.07855772,0.015436655,0.048411455,0.11994212,-0.01871578,0.0067654117,0.09361476,0.007585328,-0.0586105,-0.0076043312,0.060559824,0.00094082183,0.02303806,-0.006086909,0.0026525178,-0.011757247,-0.015640933,-0.09620541,-0.1010772,-0.007250996,0.05004482,-0.0022725754,0.066590235,-0.04025441,0.04837279,-0.010476012,-0.04359371,0.030532515,-2.591258e-08,0.027034575,-0.086874895,-0.024705067,-0.05396037,0.10157466,0.033272583,0.010059194,0.04903782,0.01215794,-0.049585976,-0.020178385,0.10341122,0.01043855,-0.02841801,0.079313606,-0.024489177,0.032523755,0.01122766,-0.016438004,-0.01345865,-0.07504754,0.023902988,-0.039665263,-0.034592684,-0.0760871,-0.016366487,0.013003175,-0.014384388,0.023378408,-0.038995523,0.06883748,0.023749787,0.01063908,-0.057329994,-0.09141897,0.10339261,0.033355676,-0.051492784,-0.03699946,0.029888902,-0.10821932,0.007634501,-0.06649219,-0.017182505,-0.017639918,-0.08007141,0.06665956,-0.009773735,-0.015511861,-0.03994932,-0.02244692,-0.029310368,-0.0021505076,-0.007772168,-0.023917729,-0.020771282,0.029999414,-0.046556253,0.006367641,-0.10855679,-0.015056111,0.059769493,0.13353044,0.046097863 +1.8.3.5,"A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18.",384,1.0,-0.050982248,-0.080479495,-0.060618684,-0.002474551,0.14263785,0.067773074,-0.022567516,0.07984856,0.08426936,-0.0037230037,0.051599815,0.06561658,-0.0983359,0.032546744,-0.057097778,0.022571322,-0.050120424,0.005651232,-0.07153858,0.022228759,-0.02045354,0.043237604,-0.029888991,-0.012548239,0.03956967,-0.08156324,0.013241283,-0.077771656,-0.028581535,0.030329667,0.04813799,0.002053909,0.086322255,0.019935997,-0.041269246,0.0665567,0.020327235,-0.06909001,0.030160464,0.035946704,-0.018685345,-0.054131817,0.028764611,-0.0153739,0.05091429,0.031289026,-0.036642868,0.048303325,-0.01710431,0.040710695,0.0019183434,-0.039884165,-0.09297646,0.0465732,-0.04138555,0.059098326,-0.08543846,-0.052951008,-0.029380266,0.033997796,-0.010135278,0.0034384958,0.055496175,-0.004189696,0.06126264,-0.05275883,0.011870179,-0.04213394,0.052758273,0.012192094,0.027980365,-0.0067768176,-0.05902044,0.091025256,0.009577757,0.037795655,-0.08738057,0.008407077,0.033628095,-0.030544048,0.0903834,0.007161301,0.07405174,0.06491744,0.06673278,-0.029006414,-0.05710165,0.025219662,-0.047145743,0.010589265,0.015050488,0.0055031218,0.015052148,0.0363228,-0.08896173,0.047602948,0.070117526,-0.03785627,-0.053462464,-0.0023654816,-0.032802563,-0.0178495,0.034063015,0.024401201,-0.010378977,-0.0650434,-0.03558599,0.06712881,-0.071132556,-0.036985967,0.042484827,-0.049011666,0.03942348,-0.0759089,0.003046548,-0.00080040685,-0.041230626,-0.0025186674,0.025585596,-0.006267158,-0.025509061,0.10737988,0.056074735,0.12648499,0.04404686,-0.014307596,-0.08322915,4.1871296e-33,0.096305184,-0.027780835,0.01793396,0.021271931,-0.030416178,-0.02936807,-0.054135907,-0.00499229,0.057618145,-0.018874941,-0.018136803,-0.0014627167,-0.014282545,-0.05434448,0.034676727,0.020609813,-0.063970715,-0.03561362,0.1145938,-0.08353842,-0.022156378,0.0766262,0.0286893,0.006805411,0.023929287,-0.026272042,-0.06330343,-0.04257885,0.005889254,0.055309523,-0.082658604,-0.04434513,-0.029489404,-0.041264683,-0.044573434,0.017449154,-0.06705338,-0.10420696,-0.08913808,0.044625923,0.014580179,-0.0076548075,-0.022046138,-0.045566577,0.029932952,-0.038596224,-0.08456107,0.0819202,-0.058937296,0.030577488,0.057795502,-0.08690358,0.08275285,0.068849415,-0.12302724,-0.0041310205,-0.03915796,-0.02399947,-0.049336385,0.052004885,0.018689204,0.0663606,-0.022842446,0.025331853,-0.07765003,-0.049164325,-0.029736951,-0.07921908,-0.0060438197,0.10283173,0.038136233,-0.037449725,0.1020532,-0.009535171,0.087463066,-0.05106923,-0.039994188,0.020380303,0.0025204679,0.047660526,-0.03532962,-0.0013667747,-0.060614303,0.007174408,-0.02446166,-0.014993089,0.04995798,-0.04633866,0.032561485,-0.0018601399,0.011753657,-0.051879536,0.01530146,0.03690937,0.02710019,-3.911605e-33,0.034339603,-0.11021022,-0.0032787558,0.056275975,0.007002598,0.039895184,0.020635188,-0.0058103967,-0.028057326,-0.049043886,0.024594553,-0.0873795,-0.061212417,-0.021401413,0.06363742,0.010808078,-0.08259408,-0.006404674,0.038531072,0.017526878,-0.07230855,-0.048584618,0.05743314,0.09689131,0.09383165,-0.024508052,-0.007616344,-0.02168545,0.0071119284,0.06551541,-0.046549015,0.02032204,-0.06025973,-0.02614698,-0.06961512,0.039857265,-0.016920932,0.039249722,0.012629434,-0.00090429955,0.019837424,0.002035704,0.0021925461,0.043378092,0.023152335,0.049827933,-0.012732868,0.0630198,0.095827155,-0.07811257,0.000108536275,-0.0010860696,-0.011226157,0.037170973,0.008006498,0.0669999,0.018367985,0.037161823,-0.0075412444,0.010415772,-0.03105475,-0.12686889,-0.007066348,-0.0071772924,0.11509508,0.024455387,-0.0025418843,0.13312519,0.0002868301,-0.009536461,0.11527226,-0.0020665936,0.048315935,0.07479652,0.061001033,-0.05294911,-0.03454774,0.021051776,0.04001737,0.026682239,-0.015718061,-0.010794303,-0.022675045,0.048803736,-0.05342706,-0.122688144,0.062015444,0.0781391,0.0007033167,0.021082785,-0.0134251425,0.050706577,-0.0061167246,-0.01236524,0.035572644,-4.1135827e-08,0.045156717,-0.04277023,-0.052463736,-0.032448392,0.065746956,0.019496921,0.0044481903,0.05512873,-0.010167381,-0.0071504842,-0.065701835,0.116791494,-0.025177658,-0.010379699,0.029871836,-0.026071591,-0.016058246,0.037999928,-0.014211049,0.006052985,-0.03863009,0.04061217,-0.08640213,-0.058034036,-0.08703674,-0.027116327,0.025073769,0.03330165,0.035454433,-0.0124665545,0.0094555775,0.005615566,-0.010523528,0.010472061,-0.06589484,0.0365553,-0.013700603,-0.09815753,-0.036895383,0.07218508,-0.110882305,0.016205328,-0.05117961,-0.012337158,0.023122823,-0.053030837,0.062396225,0.086023614,-0.062145416,-0.0047096945,-0.0145469075,-0.027527994,-0.026826179,-0.014975039,-0.0489815,-0.052467097,0.0070757214,-0.05511198,-0.0059823426,-0.076718934,0.008828361,0.056905746,0.17819655,0.03519038 +1.8.4.1,The reactions catalysed by this enzyme and by others in this subclass may be similar to those catalysed by EC 2.5.1.18 glutathione transferase.,384,1.0,-0.084935546,-0.022812301,-0.027397104,0.016295323,0.11447356,0.006997242,-0.062591895,0.038082965,-0.012963114,-0.06676195,0.055875946,-0.07235379,-0.05837554,-0.023203945,-0.056572143,0.029531457,-0.002262605,-0.03928808,-0.101217896,-0.07370883,0.04852667,-0.016008176,-0.026197605,-0.020569181,0.011274108,0.032892894,0.056074314,-0.042212207,-0.025309265,-0.088730656,-0.0033502684,-0.07461913,-0.025006657,-0.041821178,-0.008101129,0.06307617,-0.08811303,-0.080434084,-0.005205836,-0.0034152817,0.05934161,-0.027376885,0.031381477,-0.07749425,0.028918412,-0.044617098,-0.034353986,0.013035306,-0.0028467868,-0.048095442,0.028209789,-0.07955455,-0.038232844,-0.00034499567,0.039226636,0.001446213,-0.022628719,-0.033168007,-0.012453704,0.019456876,0.03260232,0.03352323,-0.0118906405,-0.079076864,-0.007519176,-0.06871518,0.059665743,-0.0924562,0.008265435,-0.035335142,-0.07933192,-0.063444376,-0.02414759,-0.0041130004,0.017262178,-0.011708274,-0.048438523,-0.03284811,0.059560917,-0.010623034,0.053385522,-0.044862885,0.00073273375,0.014666734,0.009281576,0.042319015,0.016127896,0.0141372895,0.0485469,0.014227954,0.008148365,-0.03656425,-0.011094426,-0.00538784,-0.091236204,0.06992884,-0.06583066,0.103598006,0.06540298,-0.032338683,0.0028387874,0.08816695,-0.072425626,-0.066945866,-0.0641858,0.005726453,0.0863256,0.09628315,0.030285109,-0.049318887,-0.019356541,-0.036815636,-0.010076622,0.001807,-0.006709137,0.15848854,0.028489215,-0.04003595,-0.08133317,0.045144513,0.10195007,0.0036947473,0.055691183,0.08012729,-0.043444663,0.027759504,-0.12839179,1.5051729e-33,0.051250774,0.06495277,0.01673962,-0.027751265,0.011799174,0.0136462245,-0.13700297,0.021225689,-0.04199754,-0.06811732,-0.10579072,-0.018501392,0.024296215,-0.0038643964,-0.038834058,-0.043878768,-0.025220424,0.01989935,0.035319176,-0.011213464,0.067538776,0.048555467,-0.040089518,0.021425586,0.027652953,0.083508424,-0.020075763,-0.015997153,0.069227606,-0.010764489,-0.013007224,-0.061305698,-0.06126045,-0.0008598624,-0.017800137,-0.009837259,0.008577966,-0.01309192,0.044621583,-0.03735065,0.035988823,0.034424156,-0.009449148,-0.017551024,0.07236926,-0.04292581,-0.04898338,0.05108329,0.0979934,0.08428275,-0.009937972,-0.05543805,0.09687316,-0.0453583,-0.009538569,0.011893348,0.016037673,0.045421492,0.053625423,0.08652776,-0.0054054568,0.15134282,-0.019700918,-0.035354644,-0.028807368,0.05699987,-0.060205154,-0.020125654,0.026371503,0.09061821,-0.05013733,0.034537107,0.028825039,0.0754409,0.09634447,-0.07718806,-0.05060698,0.014493588,-0.012539555,0.036436953,-0.063424125,0.024099674,0.01880526,-0.017063763,-0.09151697,0.02697999,-0.050458487,-0.019156024,0.031634923,0.12497374,0.0643317,-0.035309296,-0.0345324,0.016505016,0.020036167,-2.8562904e-33,0.11995731,-0.05246494,-0.010172384,-0.07615875,-0.0047599943,0.0574544,0.010527235,-0.011655055,0.06305834,0.044862207,0.05524121,0.015962144,0.036386855,-0.03519215,0.053607725,-0.057511397,-0.05275575,0.06603315,0.0076137357,-0.017185997,0.043401115,0.07943056,0.040958878,0.03836444,0.07830507,0.02914653,0.022326544,0.06878883,0.09170748,0.03768213,-0.07215086,-0.03876032,-0.015029914,-0.012909884,-0.008129296,0.035949882,0.0034957794,0.0378914,-0.002718142,-0.01679944,-0.050742533,0.031826515,0.001128932,0.1076266,0.021646855,0.06968812,-0.039589997,0.042770054,-0.044887085,-0.076955244,0.021319909,0.0035498266,-0.08879921,-0.019463457,0.024353234,0.03587537,0.025236886,0.0204011,-0.04858174,-0.02084065,-0.019320354,-0.082746506,0.014053534,-0.079706915,0.026111642,0.025076078,0.009231264,0.025484832,0.0017079804,0.024834858,0.07709284,-0.04324002,0.0007235574,-0.0033015846,0.019364541,-0.038619045,-0.003573155,0.018158637,0.053306006,-0.07575079,0.030830657,0.024581136,0.0199944,-0.049508557,0.0008762242,-0.059294418,0.031166662,0.12742151,0.010293372,0.053939696,-0.10320159,0.014019375,-0.011704143,0.014467301,0.012533048,-3.152641e-08,0.010021479,-0.06967494,0.059923586,0.007326934,0.038316384,0.07854053,-0.070529304,0.031013407,0.06673354,0.015894322,-0.04620873,0.10248855,0.039711002,-0.027468996,-0.021292927,0.0043045618,0.0048964317,0.03365018,0.007873362,0.011982786,-0.055676308,0.000729094,-0.097947456,-0.0368574,-0.06120789,-0.08724316,0.009595701,0.043811467,-0.051376455,-0.09114206,-0.009110956,0.018699605,0.0037122576,-0.015539594,-0.002824765,0.03617546,-0.04287661,-0.028273167,-0.025578381,0.0032644097,0.00061700767,-0.071247056,-0.051976122,0.011381345,0.022123065,0.002656511,0.014477952,-0.08954851,0.0041225376,0.053883854,0.038102902,-0.0793542,0.008104057,-0.04786928,-0.09282301,-0.008274035,-0.030843688,-0.12248285,0.03145967,-0.048400275,0.05490801,0.04863945,0.15100728,0.0580424 +1.8.4.2,Reduces insulin and some other proteins.,384,1.0,-0.033695806,0.11230171,-0.023879644,0.099883206,0.049565073,0.021807635,0.10187871,-0.0010195296,-0.018861266,0.0072301193,-0.04407179,0.08534479,-0.0473999,-0.011383906,-0.005754968,0.0045073773,-0.015666474,0.04217202,0.0032627853,-0.09514557,0.038135804,-0.033875037,0.06294023,0.08549992,-0.034902427,-0.028743928,0.068557136,-0.03232734,-0.043911386,-0.054030627,-0.006569128,-0.039010737,0.012967957,-0.03466656,-0.08413486,0.0979541,0.023452155,-0.015618934,-0.08645672,-0.059812695,0.10471482,-0.031029088,-0.051597316,0.06771956,0.016271733,0.0028992144,-0.05992687,0.020372495,0.032149818,0.03648067,-0.10655815,-0.09570453,0.0046553765,0.0056943335,0.0640568,0.012196987,-0.14646402,0.006631734,-0.020215975,-0.028700702,-0.08060211,0.004143047,0.0007441446,0.033013165,0.08492778,-0.08310768,0.007696965,0.008322622,0.014947018,0.0404517,-0.008116183,-0.007956294,0.013094275,0.033191226,0.01622303,0.0015533905,-0.06484005,-0.051613525,0.012983689,0.05194422,0.038367312,0.02347847,0.12954614,0.102653995,-0.002911035,-0.026777504,0.027251216,-0.08258328,-0.10777308,-0.033742484,0.06671802,-0.027335385,-0.021489628,0.03559433,-0.07196787,-0.026373023,-0.03435597,-0.067934595,-0.0671962,0.04634781,0.019265765,-0.0015166999,0.036454808,-0.009186546,-0.06117557,0.0044929776,0.041935228,0.03486932,0.0039496655,0.05627461,0.009750186,0.04441413,0.0017682574,0.09060771,-0.07868173,0.12321088,0.030389097,0.00999483,-0.024981687,0.00912868,-0.06000264,-0.014483361,0.058030482,-0.050847307,-0.014197812,0.08622118,-0.009565075,-2.7882891e-33,0.0147533445,-0.0473835,-0.0020984947,-0.0015786595,0.05389964,0.015331903,-0.03721905,0.031378724,0.103656314,-0.0053892317,-0.07539919,-0.08259317,0.054442912,0.04643316,0.0021569557,-0.1184459,-0.024251228,0.08764823,0.10883106,0.030739231,-0.05680343,-0.00813005,0.05720435,-0.010730887,0.021372207,0.054350317,-0.021285346,0.02154932,0.0080659045,0.0012225268,-0.01265492,0.048883736,-0.026659397,0.01014043,0.03471644,0.028321365,0.0042122006,-0.08423522,-0.0063234535,0.06397077,0.0577834,-0.007002853,-0.015817618,-0.01610933,0.073860675,-0.01730904,0.01333133,-0.033512473,-0.0674472,-0.0071341614,0.06183466,-0.024926247,0.03614373,0.01231392,0.0106020365,-0.0078200465,-0.046464607,-0.066543415,0.0036766566,0.008685938,-0.053894535,-0.006282595,-0.035349533,0.007676751,0.0013767013,0.012422771,-0.08256518,-0.077814326,-0.10682762,0.0066362764,-0.011871625,-0.07156247,0.08182372,-0.032330237,-0.024458777,-0.0148704415,-0.03706312,-0.018387482,-0.004569335,-0.045806658,0.036736157,-0.003296188,0.010701808,0.015162326,0.06526372,-0.002088854,0.010728807,-0.007401491,0.092023045,-0.11328152,-0.07213678,0.0020985478,-0.13308996,-0.020345377,0.0012351816,1.1472641e-34,0.03505608,-0.107932925,-0.013833871,0.0014822101,-0.01041188,-0.008794014,0.06705605,-0.09096023,0.036830362,-0.07416253,0.04115943,-0.029872833,0.0029650333,-0.032915033,0.015505496,0.03645631,-0.08639245,0.03205662,-0.0744746,-0.03459143,-0.03381507,0.08551626,0.03598706,0.012908427,0.024363726,0.003088796,-0.030199727,0.07512124,0.031247726,0.016851025,-0.0043659816,-0.0313185,-0.067307025,-0.04119191,-0.009590179,0.030217096,-0.035348445,0.010395921,-0.05300671,-0.023448177,0.06344797,0.007478494,0.047935825,0.031507652,0.05559045,-0.014579859,-0.013962883,0.035068065,-0.023416981,-0.016023148,0.02075375,-0.069822446,0.008527463,0.01950847,-0.04648469,-0.054254707,0.015511564,-0.09083875,0.014677579,0.02421827,-0.050272733,-0.020215113,0.039327603,0.03826304,0.07514439,0.007870013,0.061901573,0.013010072,0.06608221,0.052402075,0.09896733,-0.028310442,0.004493491,0.04407079,-0.032493427,0.06662414,-0.05449121,0.048450485,-0.020373566,-0.03916843,-0.05343501,-0.07789316,-0.049531985,-0.12505339,-0.07414851,0.0502062,0.020575037,0.0027014501,-0.03445651,0.0729449,-0.046783824,-0.09375998,-0.01606072,0.011746173,0.011513882,-1.6958992e-08,0.07824662,-0.031478077,0.039388604,0.0013369289,-0.03946063,-0.021670975,-0.008665639,0.09528849,0.071152695,-0.039559845,0.0122881,0.13759848,0.058820512,0.047841404,0.052766144,-0.0033272028,-0.030477252,0.08449714,-0.047053587,-0.037555337,-0.10440259,-0.063245684,-0.05428752,0.018397573,-0.00907982,-0.07282906,0.11203957,0.048945855,0.0065022735,-0.06980157,0.010602291,-0.0008369477,0.10884333,0.078012414,0.017307363,0.036576625,0.09156317,0.03431277,-0.0016606766,0.026956666,-0.06198466,-0.015142891,-0.06311348,-0.022645213,-0.035709273,-0.029572414,0.03827743,0.07504821,-0.01690112,0.0606354,-0.04761998,0.044314645,-0.024870362,-0.025612047,-0.033479616,-0.0049659805,-0.079691656,-0.030293325,0.023248311,-0.025480755,-0.014086958,0.0054039326,0.116287686,-0.028344683 +1.8.4.5," In the reverse reaction, dithiothreitol can replace reduced thioredoxin, and other methyl sulfoxides can replace methionine sulfoxide.",384,0.99999994,-0.062846534,-0.014266797,0.02288447,0.032666832,-0.022160815,-0.035972442,-0.07151667,0.07610877,0.021845585,0.0063393633,0.019623524,0.031513717,-0.062157523,0.0056375726,0.0009686322,0.08041676,0.04685596,0.09339935,-0.029326586,0.006155405,-0.031294815,0.039069384,-0.07821127,-0.00023538213,0.007150339,0.10012842,-0.009938859,0.08824285,-0.028427107,-0.06533989,0.0034860817,0.0018502818,0.014330888,-0.022460306,-0.057046648,0.10935195,-0.08959959,0.004972912,0.0020611053,-0.092892155,0.0012560624,0.043868683,-0.038793184,-0.031071845,0.02493695,-0.0147806,-0.1556937,0.050505254,0.061898444,-0.039874557,-0.058228176,0.024975216,-0.0011213904,0.08181659,0.022186253,0.022167241,0.0006232806,0.010608815,-0.0034864505,-0.033450443,-0.013995739,-0.0022169994,-0.07221158,-0.05850631,0.0806432,-0.059329458,0.0059120087,-0.020774113,0.062107135,0.083750725,-0.01681313,-0.0064105853,0.05963982,-0.019342598,0.030171389,0.012800225,-0.026781583,-0.05395676,0.04144099,-0.030210122,0.087380454,0.058862492,0.05748877,0.089773595,0.05875256,-0.0025003918,-0.04883029,-0.08683692,0.032052457,-0.00031186375,0.027649373,0.03427902,0.006943998,-0.04367758,-0.026796302,0.018490754,-0.055014078,0.103631176,-0.004841737,0.03960759,0.0083553195,-0.009582128,-0.20460396,-0.1294151,-0.042519845,0.0018836142,0.058264893,0.039310146,0.0046675066,-0.006571057,0.018444987,-0.02065868,0.079307996,-0.0022164073,-0.057813738,0.04913994,0.06837835,0.016540276,-0.029730735,-0.076070614,0.023052694,-0.041915417,0.048452288,-0.052072886,-0.049699493,-0.014556294,-0.052372105,3.932257e-33,0.05465928,0.06785789,-0.006242083,-0.044345327,0.057503678,-0.03146499,-0.039575454,-0.011380742,0.017078815,-0.0775746,-0.051510587,-0.010913204,-0.085719585,-0.04449034,-0.03136416,-0.1013091,-0.036808267,0.0823918,0.056063928,-0.072615065,-0.010085218,0.02388982,-0.07092998,-0.031527795,0.025922751,0.032407444,0.031732433,0.06957928,-0.060026422,0.017863834,0.027734289,0.025896585,-0.03474798,0.017318832,-0.020422006,0.05627918,-0.049011506,-0.009446721,-0.03157883,-0.029956475,-0.0061517823,0.043143645,-0.087941214,-0.0015331483,0.022724643,-0.049245737,-0.06515064,0.02960922,0.010514433,0.00059661677,0.03381005,-0.09215758,0.010600717,-0.06361723,-0.09854653,-0.014590564,0.0025132617,-0.035054978,0.10690143,0.10959557,-0.020452347,0.008594908,-0.043563254,0.019297538,0.006402243,-0.065948345,-0.007431936,-0.0011346732,-0.028666476,0.02093777,0.01677007,-0.029173262,-0.036418464,0.045979004,-0.03967737,-0.06936417,0.0128910225,0.052266728,0.019579286,-0.06024303,0.056016702,-0.039784875,-0.03594891,0.017999228,0.012838291,0.056812543,0.022501027,-0.0783086,0.025538286,0.023715852,0.038208283,-0.08207703,-0.03137825,-0.012227233,0.014704938,-3.2146773e-33,0.01574721,-0.02406133,0.02952118,0.010982842,-0.0898276,0.025307376,0.00869505,-0.023785666,0.07216095,-0.022368018,0.09096208,-0.0582725,0.0039335634,-0.005396535,-0.03792428,0.076542474,0.053752143,-0.029681766,-0.04440271,-0.009462655,-0.004871531,0.049597993,-0.044459317,0.057529848,0.04024076,0.03544398,0.053488463,0.0870034,0.08668705,0.02833658,0.01737066,-0.01824094,0.0023541704,-0.012938696,-0.0055827335,0.100610435,-0.033056427,-0.018674864,-0.04294196,0.0023542957,0.0056684916,0.014562028,0.08655726,0.092110455,0.0405805,-0.00036120487,-0.07293039,-0.078497596,0.011378062,-0.079176225,0.11777959,-0.035622854,-0.02577279,0.10306887,-0.024046127,0.021341821,0.025667686,-0.059537012,-0.021219717,-0.037200697,0.022980379,-0.07095986,0.007860104,-0.025261583,0.06266544,0.068091676,-0.00875481,0.037261583,0.06588901,-0.054523457,0.0015732093,-0.024716899,0.08794079,-0.08483863,-0.00461465,-0.056366846,-0.046361845,0.12203415,-0.012198607,0.064572,0.028881155,0.010713161,-0.012997733,-0.048535522,-0.03994049,-0.03911143,0.010809527,0.13720047,-0.06606594,0.08263343,-0.04887152,0.01091863,0.0030019204,0.047888864,0.058774948,-2.7505717e-08,0.008803206,-0.14599505,0.02880788,0.020015135,0.016653195,0.013604223,0.0057186782,0.02701301,-0.026490163,0.023291504,-0.06821387,0.09541964,0.024969848,-0.017566236,0.019597236,0.045033786,0.013811692,0.016814796,-0.0038438034,-0.020568049,-0.043658756,0.030357217,-0.007943937,0.003428107,0.07260855,0.019997662,0.015234729,-0.081742726,-0.039854255,-0.01570046,0.028984796,0.040564466,-0.06430554,-0.012820393,-0.01604747,0.007082506,-0.038426835,-0.06828006,-0.026228983,-0.008963714,-0.03987686,0.05387604,-0.05813042,0.086311445,-0.0122965295,-0.06777445,0.070812546,0.021731207,-0.058333497,0.008557119,0.068740696,-0.017506875,0.06671118,-0.10610494,-0.07111386,0.008109093,0.044971816,0.03791486,-0.05526183,-0.014385067,0.091648,-0.013625769,0.14905158,0.017123528 +1.8.4.6,"Dithiothreitol, but not 2-mercaptoethanol, can replace a reduced thioredoxin in the reverse reaction. Does not act on free methionine (cf. EC 1.8.4.5 methionine-S-oxide reductase)",384,1.0,-0.053116735,-0.013165706,-0.008100178,0.03038455,0.07571646,-0.055288363,-0.05909762,0.11195353,0.0007765082,-0.0028673974,0.023775771,-0.04071034,-0.03151221,0.012424213,-0.016914977,0.03170693,0.020512082,0.07565982,0.006356781,0.040853728,-0.03692218,0.03577906,-0.001614902,0.015303778,0.05636062,0.014481245,0.0044729817,0.06989143,-0.04780669,-0.067108735,-0.017710594,-0.02178047,0.050785445,-0.02560393,0.0142537635,0.111879766,-0.102711216,-0.0024566362,-0.016408183,-0.11088669,0.0054718754,0.003027466,-0.028902585,-0.016622396,0.015437155,-0.0040405015,-0.09716911,0.069029704,0.050817337,-0.029887106,-0.08464287,0.003377018,0.015478847,0.07161441,-0.010977864,0.043679364,-0.023782393,-0.016943246,-0.031397767,-0.0045087165,0.0006014441,-0.028107768,-0.044162024,-0.07504194,0.119290546,-0.023351282,-0.019719353,0.0023651551,0.031331938,0.07648342,0.016759874,-0.0050748778,0.052967504,-0.0041871257,0.030131135,-0.02539601,-0.0314325,-0.024550896,0.04905125,-0.033641204,0.039166335,0.009553446,0.04364956,0.066466525,0.040619854,-0.024651725,-0.08655594,-0.07523391,0.009527105,0.014055593,0.037616964,0.0476401,-0.0044466467,-0.07022332,-0.048760384,0.020616319,-0.028200911,0.101961926,-0.025960466,0.034007423,-0.014933564,0.02073904,-0.17448941,-0.10417788,0.0065132948,-0.00496236,0.047464952,0.02199631,0.0016477838,-0.043008383,0.089395225,-0.02796246,0.061656278,0.007923043,-0.041720416,0.08236483,0.05059494,-0.012320521,-0.036413565,-0.04257242,0.0011306654,-0.043390427,0.06992939,-0.053828854,-0.054854926,-0.023488631,-0.041039564,4.204141e-33,0.009482113,0.028720723,-0.023448762,-0.041948255,0.07691378,-0.01593346,-0.058572125,-0.04239983,-0.027500864,-0.07502482,-0.060783736,-0.0341632,-0.07446304,-0.05429438,-0.013524409,-0.13168605,-0.0031363936,0.070925474,0.05183471,-0.05596918,-0.0050455434,0.021860724,-0.05335696,-0.013375,0.009451769,0.024286874,0.005999246,0.043712806,0.025467519,0.031948525,-0.020412423,0.082793,-0.018378427,0.027396845,0.011424972,0.06857725,-0.10129729,-0.014874789,-0.06761898,0.010534769,0.0028332714,0.053258855,-0.091080755,-0.017606273,0.008610321,-0.06559915,-0.061194196,0.052745257,0.007867586,-0.0026418332,0.00093516125,-0.07578936,0.015824901,-0.09515479,-0.07547931,-0.027057517,-0.0038187988,-0.007770096,0.115641646,0.122800514,-0.025371958,0.019020809,-0.053532895,0.06525807,-0.011953041,-0.019690702,-0.024021355,-0.0064367964,-0.03312481,0.042090986,0.0647021,0.0033251797,-0.025710113,0.0823047,0.0010359846,-0.05923548,0.028958304,0.045973524,0.00016136133,-0.04741777,0.060505543,-0.013390558,-0.00761271,0.027004572,0.025439668,0.06915315,-0.0039058533,-0.07100847,0.045660492,0.038706608,0.039554525,-0.0938055,-0.048981015,-0.02014671,-0.017720172,-2.6117927e-33,0.009254572,-0.032813665,0.03878234,0.031169249,-0.060442418,0.059463516,-0.0122989,0.0007903034,0.046761964,-0.019552426,0.121466875,-0.06161793,-0.04306087,-0.03614123,0.0063003115,0.06970169,0.060086645,-0.050443694,-0.034185316,-0.024482163,0.0085693775,0.00902806,-0.022463309,0.034353156,0.035801057,0.029193291,-0.0058384794,0.09735573,0.045539945,0.005280891,-0.05554226,0.028032025,-0.0093986085,0.0009175551,-0.03037875,0.076785795,-0.05049391,0.008321659,-0.0061001256,0.040051196,0.023656407,0.0095584765,0.057548296,0.09969824,0.04931738,-0.021727858,-0.09339062,-0.043122713,0.022845322,-0.08500991,0.08565329,-0.06068661,-0.004926856,0.08136219,-0.015886616,0.016766075,0.030372744,-0.033700556,0.0037603816,-0.03648183,0.0332164,-0.098409556,-0.038909666,0.0014951101,0.11848826,0.024278935,-0.014438269,0.061169185,0.060422134,-0.014277631,0.051333528,-0.03832473,0.09930843,-0.0585169,-0.02288451,-0.023843672,-0.03945904,0.11630094,0.017348025,0.002368965,0.026335848,0.007814401,0.004422015,-0.044569097,-0.008715921,-0.067858435,0.053623207,0.13380146,-0.083592266,0.11676209,-0.052411705,0.010577047,0.0134089235,0.04919584,0.077306435,-3.6245424e-08,0.06883219,-0.1079587,0.028617965,0.018098408,0.079565,0.01594783,0.00043640326,0.022662971,-0.0044511785,0.02492311,-0.08968144,0.09317727,0.03196156,-0.03767315,0.012177219,0.038075525,0.051250942,0.042404145,-0.033575166,-0.002451409,-0.051906537,0.038465504,-0.051771704,-0.004470187,0.011558478,0.018951572,-0.0032363655,-0.02995657,-0.026924554,-0.07897182,0.01609329,0.003130149,-0.030619754,0.0033141708,-0.063229054,0.0065543,-0.06733037,-0.06981465,-0.050710607,-0.004857853,-0.045518044,0.05105232,-0.016267505,0.0814958,-0.041245185,-0.053902384,0.03273593,-0.0011250104,-0.045477644,0.031154964,0.03155815,-0.032599986,0.08643481,-0.09922162,-0.09055421,0.03899673,0.08424111,0.061621092,-0.08945339,-0.068171985,0.115852214,-0.008687222,0.13001409,0.026519164 +1.8.4.7,Converts EC 1.17.1.4 xanthine dehydrogenase into EC 1.17.3.2 xanthine oxidase in the presence of glutathione disulfide; also reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol reagents.,384,0.99999994,-0.024011184,0.016387401,-0.05562667,-0.026555633,0.082538895,0.021040227,-0.04566743,0.052259333,-0.028016845,-0.05194076,0.074973054,-0.07139696,-0.039163116,-0.0536195,-0.010594698,0.0333337,0.04618843,0.046558067,-0.04472931,-0.07555236,0.0261067,-0.035392918,-0.0038623272,0.008896345,-0.009654859,0.066931315,-0.015160018,-0.0022038026,0.0004179593,-0.070801236,0.033324864,-0.06007755,0.0628335,-0.009158684,-0.04312197,0.118406534,-0.01206604,-0.054039925,0.06271883,-0.022657888,0.080267906,-0.012185372,-0.010928193,0.014189633,-0.0011137556,-0.11789199,0.009101416,0.06262528,-0.0035904597,0.011862991,-0.006682409,0.014238083,0.0097861895,0.062312555,0.053418186,-0.043721985,-0.047823764,-0.0034827616,-0.06838967,0.008885364,0.050275072,0.020741254,0.034094173,0.010833037,-0.017943965,-0.067482635,0.016253054,-0.045122493,0.038503952,-0.0024268231,-0.0363891,-0.047993734,-0.0046374733,0.0012087771,0.028981028,0.08446034,-0.015244996,-0.057459146,0.039717052,-0.046395198,0.04831907,0.056223903,0.039876763,0.014821661,0.016764589,-0.060177878,0.040987443,-0.048937563,-0.051585257,0.06147132,0.05930275,0.010796287,0.004747799,-0.0063651637,-0.03280825,0.014070786,0.034990765,0.059796486,-0.004102661,-0.031781837,-0.012120815,0.15058066,-0.1184461,-0.051195677,-0.087915674,-0.06952697,-0.010817834,0.102590695,-0.038815774,-0.027567329,0.0044585266,-0.078515776,0.027777003,0.074778944,-0.009518459,0.09385113,0.036732867,-0.022201255,-0.08384991,0.0014538959,0.05578768,-0.04093208,0.0013915435,0.095283285,-0.009544223,-0.033177555,-0.06559706,6.1537184e-33,0.036410872,0.050589643,-0.015986329,-0.04736909,0.0076057496,0.030043479,-0.11786143,0.04941547,-0.0054592425,0.004258623,-0.05053555,-0.024089703,0.05977085,0.011412822,-0.0062397043,-0.09727656,-0.048283216,0.014073874,0.08300794,-0.019490156,0.042243987,0.0084963,-0.10111336,0.0039552283,0.0032951871,0.12300115,-0.0006894752,0.027224569,0.038683895,-0.012179278,-0.0504944,-0.04752462,-0.03627886,0.07273864,-0.080476135,0.010494743,-0.033175997,-0.0685189,0.039075248,0.05780185,-0.014967162,0.036387265,0.031081494,-0.07419455,0.05618301,-0.07362922,-0.0578576,0.03019117,0.09994128,0.009291217,0.014818528,-0.044436064,0.11780386,-0.020407671,0.023344161,-0.021055121,-0.0662215,0.029335344,0.0036989814,0.04352239,-0.0089203995,0.012228439,-0.047053114,-0.014828441,-0.008053245,-0.008381491,-0.0402168,-0.1305574,-0.08123358,0.09022967,-0.109483324,-0.025338857,0.07044624,-0.032174975,0.01890248,0.008078772,-0.049703114,0.05498272,0.041158114,-0.013863097,-0.04233453,0.076969214,0.0034484335,-0.0026129778,0.02484298,-0.009580919,-0.070243225,0.03711558,0.09539335,0.045708798,-0.008684755,-0.07708811,-0.08872538,0.012419837,-0.0052175014,-5.276128e-33,0.025889376,0.019407293,0.020254092,0.02529793,-0.03482305,0.083394274,0.0028995383,0.011069431,0.0644965,-0.008886238,0.108406305,-0.033629257,0.013143638,-0.06435094,0.04531178,0.01814854,-0.0002068308,0.06496097,-0.13917698,-0.019667407,-0.01599222,0.077071235,0.015017564,0.036945537,0.085861176,0.01830731,0.052916605,0.03199111,0.11046286,0.029856931,-0.08884862,0.004477725,-0.071968846,0.0050043315,-0.028092092,0.030972756,-0.04200226,0.054541636,-0.016767252,0.11712897,0.020929527,0.03454851,0.014384802,0.07199502,0.03324349,0.10538544,-0.023811493,0.010658387,0.054343507,0.009811614,0.049323596,0.024643384,-0.061124064,0.067267366,0.008494785,0.029246874,0.014510526,0.015237591,-0.02583777,-0.033236805,-0.05151585,-0.055923134,0.06460754,-0.106239095,-0.053506803,-0.03680923,-0.038168103,0.13014674,0.047967188,0.045657113,0.11503089,-0.0933945,0.012052623,0.0071482644,-0.0024943026,-0.010663947,-0.056698095,-0.046495065,0.019938264,-0.045228314,0.051567964,0.027137205,0.06461419,-0.064284034,0.05450452,0.025650458,-0.0010683318,0.11256448,0.0059343223,-0.0061561586,-0.02388827,-0.013125896,-0.012811523,0.019116567,0.06121387,-3.6983064e-08,-0.047430877,-0.044470638,0.062946774,0.032604344,-0.013397893,0.054742683,0.030449657,0.012419676,0.012183393,0.015235943,0.00042883502,0.018502446,0.033146285,-0.06012478,-0.02605186,-0.00026048435,0.05810911,0.07014293,0.01339785,-0.051929228,-0.09477094,-0.06538622,-0.098592855,-0.01200608,-0.014695351,-0.098295204,0.036996573,-0.011402048,-0.019275965,-0.026441209,-0.021261567,-0.0043140855,0.042399123,0.018347716,-0.0559132,0.015050241,-0.048715375,0.0093612345,0.02017263,-0.032672632,-0.041365545,-0.047932044,-0.09602004,0.03654969,0.03462215,0.01163324,0.06257977,0.025067756,-0.048335455,-0.029835047,0.04696095,-0.055790767,0.044964194,-0.123257115,-0.039792318,0.035415392,-0.03921817,-0.03983212,-0.0076894816,-0.040109318,0.0070897588,-0.030774022,0.11900927,-0.053260013 +1.8.4.8,Specific for PAPS. The enzyme from Escherichia coli will use thioredoxins from other species.,384,1.0,-0.08619051,-0.027367016,-0.0246206,-0.075416885,0.023301037,0.017379783,-0.08705121,0.06050353,0.0026459421,-0.0013673821,0.06045723,0.014103863,-0.11675242,0.09199581,-0.007087486,0.04609948,0.021168193,0.056694064,0.07305185,-0.037290897,0.022664052,0.084430665,-0.04995135,0.017656274,-0.051035285,0.05102516,0.020265216,0.023942506,0.013670707,-0.042734444,-0.07913472,-0.056312487,-0.0058719926,-0.05428355,0.06050879,0.11397107,-0.1250227,-0.07853251,0.051402986,-0.07185765,0.06247162,-0.045892287,-0.050015155,-0.007700982,0.010118641,0.014658619,-0.101226814,0.049080662,-0.02335065,-0.07639868,-0.026867516,-0.009166352,0.03865956,0.018920427,-0.0039348844,-0.054397676,-0.037306238,-0.08548499,-0.06463743,6.3910666e-05,-0.07723078,0.014235452,0.004532469,0.01078977,0.06731296,-0.001763338,0.03577037,0.02005684,-0.012122593,0.03339382,-0.05363654,-0.021267097,0.015064842,0.06619929,0.006797711,0.017182728,-0.02205882,-0.06370037,0.060972627,-0.021683611,0.027804272,0.059117828,0.0430097,0.0818391,0.061210852,-0.023465933,-0.024984045,-0.010999243,-0.020270685,0.02852233,0.05853159,0.0044109873,0.031960607,-0.017699966,-0.0009528261,0.034675848,-0.07521467,0.008810556,-0.009393237,-0.112270065,-0.025819734,0.03450516,-0.07522634,-0.0930673,0.030608669,-0.0363082,0.01680141,-0.022422608,0.06425166,0.017897468,-0.0060986485,0.029053334,0.025212364,-0.08191668,0.008331752,0.04734689,0.037145197,-0.069105536,0.0046555493,-0.020901186,-0.040223457,-0.09384261,0.0018912463,0.058816895,-0.0637281,0.023866497,-0.14084773,5.813109e-34,0.0334215,0.0064472114,0.004540752,-0.07614232,0.056849495,-0.013918062,-0.0040167687,-0.068313025,-0.052277353,-0.06548171,-0.1002009,-0.09356436,-0.0789267,0.0028375844,0.08401413,0.022983853,-0.06888252,0.09057217,0.06879936,-0.02049072,-0.00817136,0.04637191,-0.02073972,0.024101451,0.102022514,0.091488086,-0.08387644,0.040902115,-0.08490438,-0.012230974,0.050340977,-0.018125659,-0.09140082,0.049391363,-0.003367974,0.048042286,0.002707186,-0.051039997,-0.07411426,0.04625243,0.045829676,0.060149033,-0.007964401,0.043725878,0.046736702,-0.06436948,-0.11557801,0.034768373,-0.016449545,0.01463377,0.037900835,-0.00855024,0.020451156,-0.088518344,-0.0056892806,-0.030338217,0.013724618,0.049844105,0.046890583,0.0417143,-0.013253286,0.01306549,-0.02016554,0.01607985,0.040095124,-0.031704556,-0.007605299,-0.008143668,-0.04222107,0.06070127,-0.029272098,-0.018908186,0.010671275,-0.015161538,0.027085664,-0.08503219,-0.043035522,0.078772426,0.052717723,0.023799632,0.03277079,-0.06368077,-0.021767883,0.021713126,-0.03523003,0.0008603819,0.038965855,0.057577282,0.042694736,0.016356638,0.10999496,-0.043091465,-0.03339513,0.050044406,-0.04831458,-2.635712e-33,0.033253282,-0.042389728,0.024103038,0.011021349,-0.06603291,0.031711265,0.01198328,-0.036257774,0.07221893,-0.005229506,0.025734339,-0.018374851,0.05484538,-0.03839498,0.011276179,0.07665338,-0.047369916,0.012260654,-0.040191386,-0.03255569,-0.008118482,0.025523964,-0.023534805,0.02921931,0.0704369,0.028595665,-0.048902616,0.0732075,-0.030951554,-0.052226968,-0.014388462,0.037874255,-0.034131713,-4.6509133e-05,-0.055528305,0.037203923,-0.011906533,0.05337932,0.020162847,-0.0075114486,0.03571479,0.055534244,0.03435231,0.09384123,-0.06724963,0.036148895,0.018312978,-0.09082497,0.017876407,-0.038500614,0.035422966,0.030040246,-0.013165844,0.054162364,-0.044977985,0.012016603,-0.025153236,-0.013549871,-0.037094414,-0.08508814,0.0021537805,-0.04654762,-0.06755096,0.05009315,0.07192792,0.023525018,-0.0066027627,0.010505131,0.03762477,-0.04073202,-0.03396967,0.057719003,0.07895421,-0.041146237,-0.02097186,-0.008544314,-0.034937076,0.053979855,0.09904318,0.052237388,-1.0328397e-05,0.012610896,-0.023232497,-0.029481277,-0.0046094535,-0.024237046,0.056454,0.11179353,-0.032210514,0.003278647,-0.023619164,-0.013308681,-0.043060325,0.016616814,0.015462606,-2.3570916e-08,0.040074907,-0.04788361,0.019140886,-0.05564488,0.050313935,-0.00078364485,-0.030876825,0.059366792,0.042353388,0.046425227,-0.0273986,0.09901826,0.03548016,-0.0561619,0.14065418,-0.07882136,0.014238786,0.014584615,-0.025739942,-0.02586846,-0.101476125,0.021012345,-0.04231056,0.045474343,0.02200096,0.038203917,0.06216491,-0.05887876,0.022182666,0.02863265,-0.029988352,0.04575466,-0.038577743,-0.022780888,0.004948827,0.05910024,-0.009132048,-0.09115382,-0.004585249,0.062078636,-0.062809885,-0.062977046,-0.06359914,0.012994788,0.0026760912,0.005612616,0.026023125,-0.039677706,-0.047653623,-0.03692799,0.05776138,-0.078716815,0.03506983,-0.081601016,-0.07356381,0.008626265,0.08394125,-0.036239672,-0.05189303,-0.07745648,0.04769305,0.01993903,0.24244265,0.0624291 +1.8.4.9,"This enzyme differs from EC 1.8.99.2, adenylyl-sulfate reductase, in using glutathione as the reductant. Glutathione can be replaced by gamma-glutamylcysteine or dithiothreitol, but not by thioredoxin, glutaredoxin or 2-sulfanylethan-1-ol (2-mercaptoethanol). The enzyme from the mouseear cress, Arabidopsis thaliana, contains a glutaredoxin-like domain. The enzyme is also found in other photosynthetic eukaryotes, e.g., the Madagascar periwinkle, Catharanthus roseus and the hollow green seaweed, Ulva intestinalis.",384,0.99999994,-0.04445854,-0.040926173,-0.11087576,-0.05688529,0.047595233,-0.025529057,-0.10566918,0.059070177,0.03633959,-0.03903931,0.08935111,-0.022632267,-0.03867184,-0.0046630865,-0.02266965,0.07481468,-0.017283766,0.010186492,-0.061629403,-0.07813951,0.020375183,0.053020924,-0.049816824,-0.004343317,0.0062800776,-0.027702902,-0.007218748,-0.014759912,-0.05189598,-0.08113223,-0.06996595,-0.107042044,0.020466859,0.029390963,0.04361654,0.09213228,-0.09569576,-0.088511884,-0.011303998,-0.08066519,0.029962413,2.4874369e-05,-0.036950532,-0.021131946,-0.030409228,-0.0052033854,-0.034375053,0.00010832141,0.031392947,-0.024690116,-0.01610824,-0.076395534,-0.0116966,0.048505433,0.044086285,-0.040751792,-0.009186175,-0.029778203,0.019608717,0.05024781,0.005529934,0.0016321006,-0.018295601,-0.0907853,0.05750877,-0.043635122,0.03120574,-0.051360715,-0.028848492,-0.0688505,0.0014860784,-0.061130855,-0.011906289,0.050516132,-0.033871196,0.043778624,-0.06399887,0.032361146,0.027126905,-0.003327213,0.06740731,0.045190472,0.071040824,0.09183936,0.074174024,-0.04168257,-0.028963722,0.04513584,-0.0017592036,0.002377211,0.05048893,0.015081298,-0.038494844,-0.033730015,-0.04462456,0.061172124,-0.066174634,0.021766027,0.022359237,-0.052415438,-0.006240263,0.025793001,-0.055310663,-0.077230625,-0.0034275253,0.004730009,0.006002579,0.09668885,0.0068534273,-0.0387956,-0.038650423,0.032188,-0.0044023893,0.0005696886,0.0017626625,0.059896234,0.03798707,-0.020921465,-0.071490765,-0.009713644,0.004196555,0.010009528,0.04727419,-0.017886735,0.031545676,0.0027993196,-0.14980018,4.9996882e-33,0.057406634,0.054619435,0.004846995,-0.06020187,0.0437143,0.0012303089,-0.07887497,0.02218998,-0.037712198,-0.071751215,-0.12936847,-0.018068995,-0.05447461,-0.02028206,0.02152422,-0.0051499694,-0.021880556,-0.03549006,0.057051368,0.004541361,0.023369262,0.0015599382,-0.053641062,-0.009067567,0.021508178,0.046692558,0.0059341714,0.0005689221,0.0011263073,-0.006957489,0.006747132,-0.083644845,-0.06774794,0.017282043,0.06634384,-0.021371394,-0.002652075,-0.058949605,-0.06720647,0.014227863,-0.027901614,0.03205368,-0.045229767,-0.024081009,0.08930716,-0.014444395,-0.0703222,0.06369983,0.082338184,0.075201735,0.03032497,0.0028224392,0.112728946,-0.042416252,-0.06320263,0.011587093,0.024181426,0.0024851263,0.04150935,0.061320964,-0.0041368427,0.05738511,-0.010211396,0.016813437,0.059495967,0.08079938,-0.066776335,-0.005920965,-0.013405284,0.05693572,-0.019173304,-0.069134526,-0.02236637,0.054797396,0.017565563,-0.10264817,-0.00070888427,0.058371305,-0.033644795,-0.0076763383,0.010768501,-0.0070152446,0.0032118997,-0.004939706,-0.10031889,0.0126690855,0.0037071574,0.0011644327,0.019969445,0.019271152,0.08587815,-0.033731785,-0.03270294,0.014029848,-0.02381472,-4.8292188e-33,0.06620759,-0.07558882,0.061890617,-0.042251706,0.0019539783,0.08218492,0.031705298,-0.008906358,0.07135548,0.021909194,0.069026254,0.04785986,-0.02610459,-0.031585578,0.04776943,0.042423036,-0.018881535,0.054896683,-0.034628447,-0.06510745,-0.06938088,0.0816922,0.017569656,0.023430154,0.05966969,0.032439116,0.044642124,0.05949693,0.03436641,-0.034137424,-0.014475101,0.0696165,-0.011328897,0.009138199,-0.038255326,0.020580595,-0.051558014,-0.001103052,-0.0041781384,0.057603266,0.005320023,0.05578567,0.032890853,0.07081432,0.019835472,0.07548279,-0.0978707,0.050541747,-0.04819186,-0.082403354,0.071704015,0.035591863,0.039804954,0.047527123,0.0670709,-0.005146798,0.035916336,-0.022319743,-0.03364479,-0.013005882,0.011100425,-0.10884251,-0.029100502,0.053649794,0.029632006,0.006731376,0.03300492,0.024666894,-0.04882336,0.090225816,0.08132218,-0.03922539,0.021130163,-0.024694804,-0.04060547,0.03127827,-0.0035304008,0.063233994,0.0021325357,-0.024986401,0.08541821,0.027035393,0.021123093,-0.05755205,0.0093733445,-0.0484521,0.020123964,0.15443563,-0.014041773,0.02504705,-0.0416138,-0.008198806,-0.04612268,9.854662e-05,0.087865226,-4.8421146e-08,0.038817436,-0.06258075,0.016276287,-0.035533793,0.063622214,-0.0012218587,0.012778857,0.07098806,0.007838584,0.052064873,-0.03215018,0.09103425,-0.0036263769,-0.08221541,-0.0066767083,0.012480187,0.09072939,0.038713716,0.050737165,0.12071898,-0.11085515,0.0083255265,-0.1848718,-0.049611542,-0.007696044,-0.03146373,0.052832726,0.038421962,0.017119896,-0.0098166,0.040601853,0.034412082,0.043214645,-0.07536148,-0.1186892,-0.0069425306,-0.03928102,-0.038662396,-0.042833727,-0.03689054,-0.009786379,0.013335953,0.005690076,-0.01562221,-0.047605526,0.020087294,0.05655365,-0.018501768,-0.03008785,0.04665398,0.03365112,-0.056313064,0.03318259,-0.10238994,-0.13067566,-0.00798997,0.033866063,-0.073262334,-0.017205756,-0.04093355,0.054309703,-0.045970645,0.19747706,0.06406144 +1.8.4.10,"Uses adenylyl sulfate, not phosphoadenylyl sulfate, distinguishing this enzyme from EC 1.8.4.8, phosphoadenylyl-sulfate reductase (thioredoxin). Uses thioredoxin as electron donor, not glutathione or other donors, distinguishing it from EC 1.8.4.9 [adenylyl-sulfate reductase (glutathione)] and EC 1.8.99.2 (adenylyl-sulfate reductase).",384,0.99999994,-0.0480007,-0.015875649,-0.070939735,-0.08119842,0.048363946,-0.017215116,-0.06545904,0.09140289,0.017248709,-0.047045533,0.06946588,-0.019713856,-0.06976138,0.009964087,-0.016973158,0.018478248,0.038022816,0.01955147,-0.027639223,-0.075114205,0.015115354,0.032958243,-0.048378296,0.03037716,0.052239038,0.031083724,0.004303865,0.034648757,-0.04422665,-0.061050277,-0.054044344,-0.09679869,0.034602422,0.00076004496,-0.0058048666,0.10635273,-0.13310742,-0.07270166,-0.04228922,-0.061784465,0.010063857,-0.03361456,-0.016139567,-0.01615466,0.004804766,0.0034698409,-0.02266538,0.042314466,0.022072017,-0.0061286795,0.023579614,-0.04632006,0.008762231,0.022346735,0.009991359,-5.812558e-05,-0.06897343,-0.06858655,-0.029572938,0.012880848,-0.023578314,0.030111752,0.017422065,-0.03353139,0.045909528,-0.043754134,0.07075111,-0.07646512,-0.04646472,-0.016032629,-0.015718495,-0.06462989,0.04535755,0.08315464,0.033315998,0.015610671,-0.012903825,-0.0016195473,0.07439703,-0.05225353,0.06965671,0.016572572,0.002455445,0.10016342,0.050034072,-0.0022196325,-0.05152418,-0.024290416,-0.049350195,0.02633611,0.100498036,0.023610024,-0.0025495116,-0.013168841,-0.033682585,0.02463307,-0.074307516,0.13612853,-0.0043025687,-0.04233098,-0.011014597,0.0634102,-0.09515679,-0.066444576,-0.013100435,-0.027805397,0.010084562,0.06517221,0.025259348,-0.027762562,0.013518575,-0.014899734,-0.0056673647,-0.045748234,-0.0076871463,0.088303,0.0070172083,-0.03338499,-0.09438913,0.022590324,0.03404583,-0.026522825,0.050822902,0.051782545,-0.023819363,0.0063444767,-0.116224945,3.9141497e-33,0.05829376,0.059323486,0.042414103,-0.078231394,0.0121050235,0.016721679,-0.06045303,0.047153868,-0.06616967,-0.06586523,-0.08335194,-0.010103845,-0.033525083,-0.014370717,0.023986567,-0.0009080645,-0.048524782,0.021978434,0.068323225,-0.030751137,0.025374265,0.010294043,-0.026004842,0.014543292,0.031321812,0.059255295,-0.017314237,0.052449737,0.007070582,0.010121291,0.019441852,-0.0767151,-0.032115404,-0.0047522057,0.00561824,-0.042097054,-0.019932967,-0.040221393,-0.07189647,0.020895936,0.0021856872,0.07059065,-0.025649477,-0.015296125,0.07781202,-0.058616657,-0.0505908,0.04638396,0.049998723,0.06701779,0.0034941328,-0.03631743,0.09723879,-0.04024917,-0.020971633,-0.008922848,-0.011846578,0.009966001,0.0010653646,0.07472109,-0.011245984,0.08287972,-0.030043848,-0.024650479,-0.019814415,0.009236986,-0.021883888,-0.0099973725,-0.036104426,0.06637916,0.0018907438,-0.005077552,-0.00059800775,0.020440215,0.027669452,-0.07424852,-0.026880188,0.033736918,-0.028267333,-0.0587839,-0.037281808,-0.008578955,0.018732158,0.015771784,-0.08232125,0.04094906,0.006574062,-0.010180372,0.06014972,0.029261608,0.022676196,-0.093308,-0.089036725,-0.014482077,-0.026222253,-4.760333e-33,0.0676111,-0.032350637,0.03778203,-0.043310486,0.02685601,0.024432236,0.057004597,-0.022859419,0.08181684,-0.012951882,0.08528872,-0.0050908364,0.0051428205,-0.09882459,0.070967905,0.031617347,-0.090551406,-0.033583045,0.000819474,-0.039388184,-0.009605599,0.045081604,0.031739302,0.007393932,0.045997005,-0.012978009,-0.04168811,0.07315355,0.10687407,-0.026903793,-0.05386288,0.018468102,-0.018614464,-0.0045876014,-0.03154193,0.091393515,-0.047740005,0.008031095,0.02675765,0.0183069,0.011765556,0.051843256,0.060141005,0.05607629,0.012744241,0.12015836,-0.07140643,0.055504877,0.06679345,-0.08833515,0.094577216,-0.007922322,0.0232088,0.09996299,0.0078044627,0.04728075,-0.018203795,0.019315694,-0.05585798,-0.017173069,0.006609621,-0.13534424,-0.03340731,-0.03361802,-0.013577882,-0.0430379,-0.015532395,0.037942637,0.008151935,0.03504837,0.0060701356,-0.04125312,0.025349863,-0.022445973,-0.066567995,-0.012413088,-0.019084573,0.07603987,0.03476869,0.0017981321,0.04267814,0.050059807,0.021714693,-0.016687876,0.051932912,0.0037944058,0.03993232,0.13205495,-0.04505897,0.06068215,-0.051557843,0.011080047,-0.020759242,-0.009186458,-0.01955963,-4.6145132e-08,0.057734817,-0.081942536,0.043944646,-0.105487384,0.112147175,0.02712148,0.015811063,0.066857934,0.021692922,0.046601098,-0.041536845,0.10882295,-0.027561788,-0.0773158,0.030020878,-0.015458832,-0.0045273504,0.052689284,0.024212006,0.007677219,-0.10017283,-0.01504196,-0.16056333,-0.0059012324,0.008482657,0.03885783,0.059776027,-0.048633456,-0.048175287,0.017586859,0.027622733,0.015428486,0.0018018638,-0.034899347,-0.03304936,0.03905189,-0.07223872,-0.0035012688,-0.058511764,0.0004504058,-0.033588868,-0.0334697,-0.06376643,0.040557615,0.032563984,0.006992294,0.053265743,-0.022202557,-0.062012725,-0.0031723436,0.051054493,-0.120433815,0.024774916,-0.120071,-0.1081187,0.003361561,0.04091379,-0.072173625,-0.004409357,-0.070692234,0.13305938,-0.006761372,0.20884103,0.063980326 +1.8.5.2,"The reaction can also proceed with ferricyanide as the electron acceptor, but more slowly. Unlike EC 1.8.2.2, thiosulfate dehydrogenase, this enzyme cannot utilize cytochrome c as an acceptor.",384,0.99999994,-0.101681076,0.032176208,-0.07597075,0.024241101,0.07187494,-0.023713721,-0.08198023,0.0758656,-0.021926751,-0.013258161,-0.0010159055,-0.065416075,-0.08307686,0.011075316,-0.045860637,-0.017185977,-0.029588996,-0.024461333,0.024468979,0.02909342,-0.041573375,-0.022836313,0.006664017,-0.042116217,-0.018529043,0.03702249,0.0049327547,0.034549776,-0.077593885,-0.10619069,-0.008797126,-0.011617724,0.036789656,0.0075380285,-0.057716116,0.10704721,-0.066273555,-0.060761426,-0.030069863,-0.025457088,-0.033664204,0.032666836,-0.039038565,0.010895427,-0.022286886,-0.07070492,0.017476661,0.0035912746,0.022932313,-0.04503907,-0.041131437,0.008032035,-0.0013320515,0.03059362,-0.027590811,0.017420929,-0.053554237,-0.063008755,-0.016869409,-0.010934809,-0.04811341,-0.03304637,-0.0020762351,0.06576954,0.03079755,-0.069055825,0.022864785,-0.1277239,-0.030151747,-0.032910086,-0.02352245,-0.045740467,0.010302484,0.004357399,-0.018348876,0.11640066,0.0031960956,-0.04889953,0.042067666,-0.024306616,0.0031282366,-0.103499934,-0.009758632,0.028148012,0.022027712,0.028210826,-0.019585265,-0.031016076,-0.028310755,0.10011608,0.08412498,0.060127884,0.032036815,-0.04988052,-0.035231296,0.00733507,0.11959567,0.09542195,0.009044942,-0.027082514,0.00253357,0.07474483,-0.06086903,-0.0380479,-0.045307275,-0.023484882,0.07384456,0.04844282,-0.03737018,-0.033235583,-0.021479879,-0.080855645,0.01633861,-0.021278642,-0.034947876,0.0877713,0.054182198,-0.10065929,0.015592279,-0.03370077,0.015085226,-0.0017576262,-0.021294903,-0.009849912,-0.0075288434,0.03511755,-0.1271763,1.6308019e-33,0.04266497,0.06731946,-0.055283893,-0.119831435,-0.040113803,0.01746047,-0.08428103,0.064033575,-0.00855823,-0.019655507,-0.09520116,2.4069062e-05,0.09652447,-0.05899479,-0.037259236,-0.034656215,0.026450878,0.0038904808,0.043626472,-0.04525311,0.09083707,-0.040219527,-0.018625928,-0.04545544,-0.009333189,0.031512503,0.005775166,0.073913515,-0.010027502,-0.0038575483,-0.0005469742,-0.06837135,-0.044764172,0.020215644,0.07691239,-0.0250809,-0.029256664,0.028504912,-0.0031255241,-0.008159425,-0.05145847,0.038704734,-0.030958729,-0.01159674,0.043016836,-0.059777673,-0.08588487,0.075212486,0.039505143,0.0861008,0.0670062,-0.030201884,0.03517039,-0.054424226,0.018926827,0.053554364,0.037585426,-0.0013179459,0.015448813,0.070336,0.04795812,0.101204805,-0.028835325,-0.008183742,0.003534364,0.0063913567,-0.069124855,-0.008024416,-0.025722276,0.037138753,-0.06701614,0.010476303,0.14331795,-0.013313823,0.08410203,0.005972139,-0.09992453,-0.025511809,0.071661435,-0.021939257,0.01077025,-0.015698627,0.007108593,0.029133571,0.023129279,0.0072785877,-0.03781985,0.0107100755,-0.0012499926,0.07055292,0.04987661,-0.08863895,-0.008735485,-0.022135992,0.06709853,-2.8715777e-33,0.084493026,-0.019725706,0.029001825,-0.049796935,0.0038496344,0.11248416,0.0149920415,-0.044504803,0.097878605,-0.007806351,0.12328755,0.027059875,0.08353079,-0.06104736,0.033582564,-0.027609436,-0.03607032,0.06377304,-0.04375593,0.02177661,0.004844608,0.019458503,-0.056338836,0.021726811,0.05912632,0.005314945,-0.0029676748,0.028594825,0.06508633,0.024315644,-0.055199184,0.011081139,-0.037373517,-0.02193351,0.059158728,0.04469887,-0.050671276,-0.0009933193,0.04749303,0.04396442,-0.032105345,-0.051042866,-3.662038e-05,0.11129248,0.060801428,0.06861779,-0.025458265,-0.01390916,0.023583442,0.0532703,0.009726088,0.03116316,-0.04552232,0.042623956,0.05479094,0.07378802,0.07006229,-0.023757659,-0.045320712,0.03089075,0.016221808,-0.09447471,0.07952292,-0.03255088,0.019953024,0.02598646,-0.10007765,0.10783463,0.06390013,-0.0008293486,0.07211528,-0.021729704,0.004188095,0.015550667,0.03789867,-0.01940269,0.034555353,-0.028546862,0.0024284641,0.0060162893,0.014407159,0.10540264,0.016619548,-0.042247236,0.05120902,-0.07014452,-0.0074651716,-0.04377964,-0.066657595,-0.043230377,0.006240939,0.0098679755,0.023497956,0.07297345,0.050877854,-3.181305e-08,-0.03801337,-0.064027,0.039750002,-0.030936278,0.09586148,0.034929365,-0.0519404,-0.06620759,0.0039255153,-0.05362172,0.0063144085,0.16094324,0.03385558,-0.0018021367,0.08035954,0.00041368298,-0.0032428282,-0.018777281,0.0038591628,0.043969546,-0.06357393,-0.03509124,-0.11713103,-0.037753187,0.003858755,-0.047784023,-0.059414092,-0.038765676,-0.032566957,0.0055032163,0.011313589,0.026576385,-0.009652522,-0.007003786,0.03201886,-0.029893812,-0.0294582,-0.05005846,-0.07315941,-0.029303255,0.07923151,0.00023939126,-0.10148309,0.049878906,0.0032520867,0.010427954,-0.01137669,-0.018141055,-0.066629164,0.019303814,0.04106331,-0.04122433,0.029587764,-0.06948076,0.03479289,0.021477481,0.021017643,-0.09139195,-0.035522845,-0.019238623,0.075015314,-0.009139829,0.18784064,-0.0042225476 +1.8.7.1,"An iron protein. The enzyme participates in sulfate assimilation. While it is usually found in cyanobacteria, plants and algae, it has also been reported in bacteria [4]. Different from EC 1.8.1.22, dissimilatory sulfite reductase system, which is involved in prokaryotic sulfur-based energy metabolism. cf. EC 1.8.1.2, assimilatory sulfite reductase (NADPH). ",384,1.0,-0.08091614,-0.03846611,-0.09574631,0.031226307,0.064525925,0.042128384,0.010752702,0.042912163,0.053642936,-0.0594221,0.012396928,-0.015530545,-0.05675458,0.021370009,-0.05545837,0.029564884,-0.015777553,0.03744108,-0.029092161,-0.054635264,0.03824257,0.010854782,-0.06851988,-0.024452833,0.03811598,0.042021256,0.005816226,0.004441108,-0.10529959,-0.040676508,-0.04496934,-0.07334851,0.05273795,-0.020463804,0.05991865,0.124716684,-0.028900474,-0.13729379,-0.011561331,-0.0374689,-0.008182575,0.031485222,-0.026067479,-0.059640795,-0.011061457,-0.0041852505,0.053365756,0.049311314,0.029204989,-0.047973797,-0.051198278,-0.036401648,-0.04249233,0.06448614,0.025376018,-0.0022403828,-0.0057514478,-0.04344725,-0.015682364,-0.0774409,0.0040689902,-0.005016613,0.01401906,-0.022338517,0.050185848,-0.035957478,0.08395138,-0.048734322,-0.020717083,-0.0753978,-0.08876389,-0.02236786,-0.051753838,0.088003255,-0.022475176,0.047650512,0.030452797,-0.05819587,0.078923345,-0.011250844,0.03417815,0.022070993,8.7083674e-05,0.05450394,0.017614355,-0.0126362005,0.008475488,-0.016238423,0.016381655,0.046694953,-0.0101646865,-0.019590829,0.0059021083,-0.040590163,-0.07326786,0.014132807,0.01311535,0.11763291,0.06611868,-0.013924224,-0.023952577,0.06823913,0.004185219,-0.063919105,-0.0060235006,-0.01992269,-0.006677984,0.16883714,-0.015608913,0.04550878,0.017508741,-0.033197362,0.02093351,-0.023878468,0.024649456,0.11284382,0.10152645,-0.038564872,-0.13248023,0.05420043,0.013454919,-0.007835776,0.02884081,0.0681124,0.022824943,0.021271352,-0.20732397,1.5196482e-34,0.0880985,0.0085174395,0.06929827,-0.018914916,-0.024550697,-0.013041593,-0.084213644,0.018115623,0.028853822,-0.034916915,-0.08479061,-0.010463894,0.075665675,-0.014017876,-0.034129553,-0.020649903,-0.016859451,-0.011781542,0.03429488,0.03454441,0.04209793,0.028885331,0.026552623,-0.0515071,0.008921508,-0.0027649337,-0.04059816,-0.018472482,-0.037429262,-0.014865267,0.02778728,-0.15684882,-0.08117718,0.021588266,0.1550967,-0.07551933,0.05816541,-0.031973157,-0.033968765,0.018040024,0.053193375,0.016083483,0.0137285665,-0.037729952,0.059903562,-0.064047255,-0.070595056,0.06840488,0.08024262,0.028058782,-0.0012841758,-0.026507463,0.11321184,-0.04013145,-0.022373844,0.0075303297,-0.002808212,-0.015974592,-2.6531377e-06,0.074460916,-0.0035087343,0.034610663,-0.030672448,-0.001105406,0.04788039,0.01180191,-0.07136275,0.02117936,0.041917704,0.0936914,-0.08787501,-0.02682934,0.055816773,0.01939205,-0.015364293,-0.06539425,-0.07604343,-0.008411817,0.007203473,0.022210136,-0.056379862,-0.08705631,-0.047431953,-0.006031601,-0.1229394,0.01954321,-0.007312507,-0.035590366,0.010239049,-0.02812819,0.051636342,-0.016886817,-0.08042627,-0.014091052,-0.018243022,-2.9014492e-33,0.06105115,-0.0593034,-0.012848487,-0.08184823,-0.034844194,0.042986836,0.033508897,0.01961437,0.011985307,0.03594844,0.06617474,-0.0031115192,0.043488067,-0.03950797,0.036874883,0.054395683,-0.015589673,0.041101873,0.013355104,0.03148427,-0.07647614,0.083698474,0.072960064,-0.0053344527,0.032763332,-0.0080106985,-0.025683977,0.04132666,0.020129712,0.045334153,-0.01194689,0.040678766,-0.009110663,-0.10305249,-0.077631235,-0.0023038979,-0.062349953,-0.038025007,0.06602662,0.0203544,0.046772927,-0.028820343,-0.014595143,0.11481959,0.04665429,0.044503402,-0.042086214,0.06564609,0.0040898984,-0.013649605,0.06796505,-0.034445595,0.026393674,0.051565025,0.006555248,0.012630044,-0.0049198684,0.0798007,-0.019845916,0.06351902,-0.031973694,-0.066595584,0.058629856,-0.0029033234,0.006801402,0.04103583,-0.035823938,-0.015605104,0.028182248,-0.009947846,0.034254324,-0.039188795,0.004759719,-0.009930436,-0.041596387,-0.052924078,-0.056701086,0.0582845,-0.03585472,0.03195756,-0.06678218,0.031483307,-0.0118260365,-0.08544165,0.06831092,-0.08378636,-0.020498706,0.03404321,-0.021735054,0.0019315673,-0.07474129,-0.038187597,-0.045775585,0.026043283,-0.055762567,-4.1618428e-08,-0.010206682,0.018960485,0.07230324,0.030980712,0.038478795,0.05112335,0.0643862,-0.04363923,0.012823352,0.077517055,0.012866781,0.12088484,0.015266029,-0.06602329,0.06881689,0.03968978,-0.014748072,0.044004507,-0.02389419,0.010737797,0.013528803,-0.04244114,-0.107640475,0.075913556,0.05141963,-0.06569037,0.0013893073,-0.03547087,-0.0022250894,-0.051899325,-0.003716842,0.042295065,0.038788334,-0.056246143,-0.062357765,0.012149147,-0.06568354,-0.023294784,-0.049108647,0.020685712,-0.047383253,0.037489377,-0.10752709,0.007638682,0.026736844,0.06467152,-0.0041309954,0.049427163,-0.026968116,0.0068774386,0.061289582,-0.026837809,-0.015788272,-0.06158553,-0.06647493,0.049916994,0.039267335,-0.07105018,0.037433542,0.054460827,0.033456665,-0.045453902,0.09369348,-0.057580452 +1.8.98.1,"This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase and EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.",384,1.0,-0.044577178,-0.018878162,-0.12724854,-0.03412921,0.07515377,0.016320733,-0.08171302,-0.008984114,0.009407607,-0.088225275,-0.035394512,-0.079560585,-0.050118633,0.011216779,-0.062000535,0.029599857,-0.048855476,-0.05097025,-0.01506705,-0.057403937,0.02729139,0.094080314,-0.023302488,-0.0022440976,-0.062414806,0.0069393255,0.051983204,-0.046861358,-0.090413444,-0.08099532,-0.02054062,-0.059600625,0.0921603,-0.0011464831,0.053672846,0.10576239,0.010067465,-0.08434386,0.029348327,-0.031914055,-0.006464585,0.04855263,0.059510935,-0.02337889,-0.036341228,0.006835425,0.012194185,-0.023376647,0.011047923,-0.080848485,-0.03536653,-0.027493313,-0.08503166,0.15755986,0.0934553,0.051597,-0.016318219,-0.04247055,0.026195405,-0.03765222,0.038597222,-0.008602294,0.07237341,-0.030955203,-0.03588316,0.018280031,0.079412356,-0.066899434,0.05127229,-0.04932788,-0.046507005,0.018828992,-0.04947683,-0.045206044,-0.026700905,0.052833606,0.0023783566,-0.026150526,0.051185653,-0.031992644,-0.016421948,-0.003631738,0.041445233,0.04072489,0.025060682,-0.061154287,-0.066092394,-0.047983218,0.03823259,-0.0017978775,0.03179008,0.020455522,-0.018043235,-0.017935548,-0.08823909,-0.030313851,0.06161887,0.079618685,0.05196243,-0.013383553,-0.03361443,0.03206297,-0.034801785,-0.06835315,-0.08301819,-0.06608839,0.06919849,0.18185818,0.07739219,0.022675319,0.037246205,0.005479986,0.09875096,0.008001694,-0.01355565,0.06798564,0.03370391,-0.060666315,-0.02593246,0.05780602,0.051487714,0.03889866,0.1074173,0.0027037673,-0.0045116902,0.009913411,-0.16785754,5.681686e-33,0.100475796,0.03135542,0.035499036,0.023581656,-0.029387398,-0.013985874,-0.11052937,0.02283924,-0.041782353,-0.05046931,-0.07202138,-0.02599609,0.07926469,-0.077053405,-0.029337985,-0.073401436,-0.008298317,-0.01954786,0.015735274,-0.009640638,-0.0058284868,0.066979386,-0.027406491,0.006841307,0.027814325,-0.0341043,0.006920206,0.0006185543,0.07074807,0.014309123,-0.01538498,-0.09434124,-0.07584822,-0.016314488,0.049385004,0.011669069,-0.05759116,-8.157263e-05,-0.080970675,0.0032252097,0.0012870176,0.030431323,-0.020966616,-0.060968664,0.13378653,-0.07860461,-0.07926008,0.14643256,0.054013703,0.08059612,-0.0577883,-0.026176162,0.11011207,-0.010191081,-0.07605802,0.00077554624,-0.0024917177,0.009676115,0.08590294,0.07427228,0.07348751,0.05668194,-0.052242078,0.0368038,0.034778267,0.061312214,0.01153917,0.002069273,-0.0036412342,0.10064901,-0.013976364,-0.008698903,0.045025054,0.07349144,0.032451198,-0.070803806,-0.005126934,-0.07784487,0.02804498,-0.022975503,0.01953654,-0.057507772,0.037702844,-0.039629705,-0.054241814,-0.03174989,-0.028763032,-0.019612635,-0.015393455,0.029219406,0.052517448,-0.03786806,-0.039646976,0.004706306,-0.023321807,-5.2303305e-33,0.09350234,-0.05952567,0.02095237,-0.10305658,-0.038239963,0.07952908,0.02467982,-0.037645765,0.018403763,-0.047418844,0.13076036,0.038572796,0.021171875,-0.041719705,0.056905843,0.020205703,-0.024747664,0.030727593,0.057214405,0.027869083,0.042220093,0.0068669417,-0.017987235,-0.0058539202,0.009259391,0.023173029,0.007322323,0.08118739,0.07065016,0.047749214,-0.025720747,-0.0042138803,-0.07837713,-0.018709991,-0.11904151,0.012551889,-0.069874406,-0.020593932,0.04166994,-0.023724496,-0.0053982222,0.038444884,-0.017235525,0.05741556,0.057361256,0.063167244,-0.08954745,0.06321784,0.043352887,-0.011919401,-0.037162073,-0.014212483,-0.057442695,-0.05203235,-0.010569385,0.033229634,-0.006313498,0.037300322,-0.01724739,-0.007129558,-0.014954372,-0.07405896,0.06077047,0.02642498,0.033245694,0.043573085,-0.0030884717,0.01899222,0.034005,0.04965885,0.02357468,0.025424931,0.0040311003,0.0264955,-0.013240028,-0.02288449,-0.037219226,0.028847657,-0.023791423,0.035901632,0.012546843,0.029130267,0.089246646,-0.042822953,0.0052898526,-0.08819441,0.028359387,0.04745128,-0.004885869,0.019579299,-0.079411395,-0.027490443,-0.032152444,-0.009297436,0.009686149,-4.796744e-08,0.024447598,-0.04756581,0.056820586,-0.0064772377,0.060017526,0.07090052,0.04661952,-0.025642626,0.016816191,-0.022164298,-0.014662683,0.049672257,0.0008954652,-0.031223504,-0.013636159,0.042978354,-0.04795208,-0.039942153,-0.011827765,-0.0005547122,-0.018345779,-0.050807465,-0.03926828,0.038821854,0.006350999,-0.0915272,-0.019948952,0.012185783,-0.012646696,-0.08839624,-0.016696727,0.04695322,0.047371853,-0.036003835,-0.083361045,-0.008077884,-0.07970237,0.032662153,-0.059346486,0.04424139,0.016889751,0.012783149,-0.051333167,0.0038879632,0.08355519,-0.010506401,-0.0032699597,0.042373765,-0.025100263,-3.541778e-05,0.07127089,0.00480367,0.04770434,-0.002457245,-0.0904137,0.016334295,-0.0054152207,-0.021922847,6.3495456e-05,0.006791247,0.051122308,-0.018118825,0.107066974,-0.02242357 +1.8.98.2,"In the course of the reactions of the peroxiredoxins (EC 1.11.1.24, EC 1.11.1.25, EC 1.11.1.26, EC 1.11.1.27, EC 1.11.1.28 and EC 1.11.1.29), the peroxidatic cysteine residue is alternately oxidized to the sulfenic acid, S-hydroxycysteine, and reduced back to cysteine. Occasionally the S-hydroxycysteine residue is further oxidized to the sulfinic acid S-hydroxy-S-oxocysteine, thereby inactivating the enzyme. The reductase provides a mechanism for regenerating the active form of peroxiredoxin, i.e. the peroxiredoxin-(S-hydroxycysteine) form. Apparently the reductase first catalyses the phosphorylation of the -S(O)-OH group by ATP to give -S(O)-O-P, which is attached to the peroxiredoxin by a cysteine residue, forming an -S(O)-S- link between the two enzymes. Attack by a thiol splits this bond, leaving the peroxiredoxin as the sulfenic acid and the reductase as the thiol.",384,1.0,-0.05335664,-0.051606596,-0.059071776,0.03162118,0.1053456,0.060734186,-0.066566266,0.039922014,0.06723689,-0.037260305,-0.021628434,0.10833528,0.035135582,-0.007814753,-0.09146578,0.06400601,-0.028191589,0.043153543,-0.008494774,-0.020893876,-0.0029209047,-0.08431405,-0.057955626,0.034890376,0.023219185,0.015048682,0.00031708603,0.0025798539,-0.1284901,-0.020830683,-0.05582336,-0.023993488,0.033584274,-0.013631652,-0.01662444,0.102286115,-0.050701004,-9.015014e-05,-0.05669513,-0.0178287,-0.026467338,-0.03627743,-0.04168212,0.025560983,-0.008662949,-0.013244983,0.025560817,0.036893677,0.019195009,-0.0468167,0.05875671,-0.022275819,-0.042808354,0.033179875,0.031896662,0.02822998,-0.061742835,0.025171604,-0.013309171,-0.016814116,-0.041121397,-0.02699924,-0.011189825,-0.009788866,0.025092091,-0.043455128,0.08786956,-0.08170818,-0.026470428,-0.055161424,-0.004015205,-0.035319485,0.014594402,-0.02034097,0.0024898702,0.058127142,-0.028956631,0.0040218583,0.043257684,-0.020173406,0.044305388,0.029071279,-0.002212006,0.107839905,0.08174251,-0.07292466,-0.024954908,-0.04632734,0.025961882,0.057664108,-0.0103651555,-0.014816743,-0.09994411,0.0062813493,0.001044291,0.0051234146,-0.003326824,0.12244516,0.0020858021,-0.031682696,-0.014967162,0.1019274,-0.04489198,-0.11073281,-0.014893296,-0.0106214825,-0.026944222,0.110567935,0.024674037,0.015661009,0.027321182,0.003478614,0.035052586,0.01088617,-0.0071263975,0.11946556,0.029576112,0.00350819,-0.076818965,0.024125384,-0.006856092,0.012219483,-0.032977935,0.019313224,0.0109165255,-0.012581303,-0.068091094,2.6699093e-33,0.105594255,0.091205634,0.02217995,0.02493267,-0.026760744,0.014367421,-0.077841744,0.057201635,0.043122984,0.02586546,-0.06630069,0.006799442,0.045284003,-0.053690787,-0.070266284,-0.08032485,0.009996752,-0.11562341,0.023219094,-0.05168206,0.011988567,0.019608257,-0.056463026,-0.008174522,-0.023552058,0.06497772,0.0026971423,-0.01552726,-0.031262416,0.020621033,-0.010276872,-0.041598573,-0.059066467,-0.0069105667,0.013090877,-0.025286946,-0.035850387,0.012379016,0.031484064,0.047656085,-0.0169983,0.039580204,-0.008686287,-0.07400716,0.0591627,-0.123494245,-0.07641717,0.16687058,0.051355727,0.05697196,0.04950625,-0.06849485,0.092963174,-0.021166781,-0.092285804,-0.018053032,-0.015119517,-0.031948358,-0.0072329435,0.08345532,0.06664012,0.05432512,-0.046793092,0.024383867,0.052152324,0.07764688,-0.05135783,-0.06076461,-0.09194074,0.011885651,-0.016479542,0.042717822,0.047372606,-0.0050877887,-0.03054318,-0.00294871,0.027217275,0.09466847,0.08660533,0.040401556,-0.036497,-0.005528868,-0.028388375,0.044333026,-0.043111797,-0.011386133,0.0045886375,-0.052501947,-0.039092824,0.00697178,0.0939311,-0.09233886,-0.019534621,-0.029119879,0.024753563,-3.23651e-33,0.018311067,-0.09292876,-0.0036142839,-0.10990626,0.077622,0.052784428,0.05400006,0.0069480306,0.021632738,-0.027688906,-0.009812321,-0.033191573,-0.028128449,-0.012820148,-0.013635945,0.0011676113,-0.054613926,0.07314534,-0.061554547,0.03772952,0.014645947,0.069594875,0.047460027,0.07763464,0.05944501,-0.021040928,0.021859596,0.043694526,0.035183333,0.10796186,-0.033349797,-0.009931587,-0.034339283,-0.019683613,0.0024189954,0.12233512,-0.116756044,0.04925417,0.018941768,0.017329382,0.036450047,-0.010428968,-0.022687318,0.07049278,0.10366646,0.0905473,-0.15191717,0.07494955,0.0032557112,-0.09501731,0.05307265,0.016543675,0.02860205,0.009126889,0.02397046,0.036508888,-0.004999086,-0.021495476,0.044809766,-0.018675363,-0.06157614,-0.016770663,-0.05083612,0.011515948,-0.055322286,0.011193468,-0.010051049,-0.047999304,0.027846182,-0.00862463,0.011973704,-0.0274279,-0.010634385,-0.005638106,-0.040776487,-0.059447423,-0.02938542,0.06196735,0.010223076,0.016171,0.034999773,0.010010837,-0.0024884932,-0.05784241,0.017359894,-0.020728458,0.031520206,0.0802927,-0.0022483156,-0.0320348,-0.032265704,0.03010278,-0.050580256,0.032267295,0.042938493,-5.216484e-08,0.030999897,-0.047804173,0.067747705,0.0062077516,0.06523997,0.032438327,0.075295605,0.07142042,-0.008038216,-0.06473083,0.04424318,0.08742478,0.028941022,-0.11020793,0.04309505,0.059701495,0.031256348,0.025313469,-0.018361846,0.03477392,-0.023155274,-0.06703868,-0.08387055,0.015506288,0.016875997,-0.07429161,0.03749391,-0.06431277,-0.03218894,-0.03563253,0.113207474,-0.030053824,-0.0042624073,0.0025514686,-0.10941437,0.043418054,-0.034197174,0.0024306194,0.038846754,-0.062168255,-0.089464545,-0.0014008763,-0.06295136,0.033264868,0.024763266,-0.022386469,-0.011337409,0.050097916,-0.026188083,0.015082378,0.021627015,-0.054524012,-0.03564857,-0.10827477,-0.063115954,-0.006497198,0.09483389,-0.067825034,0.030236717,-0.063318245,-0.008102691,0.046503466,0.08416125,-0.0050274604 +1.8.99.1,An iron-protein. A stoichiometry of six molecules of reduced methyl viologen per molecule of sulfide formed was found.,384,1.0,0.011227628,-0.016263945,-0.096777685,0.04967458,0.053304695,0.04162753,-0.030046958,0.040580828,0.013362486,-0.06030412,0.02223882,-0.025141304,-0.010413449,-0.06861746,-0.056342375,0.016794628,-0.022602845,0.023374433,-0.009273986,-0.009184116,0.03365094,-0.023875691,0.009385764,-0.087298535,-0.05452398,0.11661538,0.013945062,0.07274709,0.005575547,0.003511949,0.015602234,0.0024738165,-0.006002812,-0.030500397,0.022979544,-0.00062663073,-0.013244531,-0.074118,-0.028856425,-0.04091071,-0.03896681,0.04781082,-0.030991223,-0.034052502,-0.03200046,-0.02301945,0.046094332,0.008785291,0.015034948,0.009934067,-0.080007866,-0.05058124,-0.029729623,0.06768393,0.0020600844,-0.046142068,-0.040997267,-0.03969604,-0.01612195,-0.04759264,0.015846964,0.020923192,-0.017754108,-0.06655691,0.014933631,0.022795565,0.09637198,-0.032771,0.032216698,-0.0045807897,-0.08358243,0.058549426,-0.05360172,0.03857267,-0.027355948,0.09328764,0.043606147,-0.09657859,0.06444326,-0.012283843,-0.03517637,0.05552481,0.075319596,0.09045923,0.025307963,-0.01374911,0.019970512,-0.011380434,-0.010939798,0.057087973,-0.020765899,0.04617255,0.019892782,-0.016413026,-0.0365618,0.057361733,0.021656487,0.05917161,0.061340928,0.0038273537,0.015775658,0.014992826,-0.07281032,-0.09824355,0.03561409,0.043278452,-0.0051001413,0.16734008,-0.02439841,0.022608664,0.02132456,0.066665865,0.037851125,-0.050279956,0.009552754,0.1369744,0.09165696,-0.009899186,-0.09053698,0.032746732,0.0390099,0.08523517,0.044885278,0.010010828,-0.057557236,-0.036555506,-0.11894782,-1.2220728e-33,0.07062869,0.040738575,0.14029603,0.042284414,-0.0495384,-0.014845429,-0.064122185,0.03559716,0.007556757,0.03900266,-0.071481444,-0.14035074,0.077810965,0.002315707,-0.04678129,-0.03560474,0.0294411,-0.052900646,0.042076807,-0.06990689,-0.026473045,0.1042324,0.10769141,-0.1083527,-0.044793036,0.018479524,0.015641421,-0.0488937,-0.022266563,-0.01648491,0.018740045,-0.067527115,-0.06462674,-0.0049544675,0.14591339,-0.008677725,-0.019639103,0.0055023623,-0.032645296,0.010557893,0.112967834,0.025240162,-0.026824258,-0.041998144,0.06633952,-0.09227402,-0.0808923,-0.0021022777,0.025434643,0.040407255,-0.0066527883,0.02210314,0.033628322,0.005649249,-0.10036793,-0.013458273,0.045460552,0.018554933,-0.026672916,0.08591159,-0.013474558,0.022029031,0.02062014,0.03896762,-0.024026243,-0.055652905,-0.067344494,0.023301898,-0.044162124,0.06489441,-0.0029323127,-0.022181503,0.07161723,-0.060677346,0.008753961,-0.05932477,-0.06532157,-0.07865901,0.08127413,0.03109167,-0.050503243,0.014132716,-0.04702266,-0.09142814,-0.15516293,-0.014702685,-0.028755497,-0.010529076,0.042317286,-0.0191834,-0.005215883,-0.04185395,-0.06815435,-0.054690093,-0.046176948,-2.7567631e-33,-0.030180754,0.007346902,0.04015485,-0.029569088,-0.05503529,-0.0019738146,0.03952975,-0.0010492492,-0.06951897,0.036379993,0.1609341,0.00028781046,0.024765952,-0.07725218,-0.014026084,0.11623224,-0.0069413097,-0.00493179,0.09828721,0.029567758,-0.08846763,0.023568122,0.04305638,0.033034697,-0.0012497624,0.003526509,0.08302396,-0.032700736,0.059946816,0.10128696,0.07210333,0.026593795,-0.014258879,-0.07130043,0.0013279727,-0.01656983,0.0028573186,-0.039340086,0.02421069,0.008244222,-0.018142354,-0.02580279,0.019412164,0.11019725,0.071639426,0.038981784,-0.07046713,-0.011369194,-0.013703821,-0.027681753,0.053388875,-0.06940468,0.015589236,0.02617491,0.021583457,0.015813958,-0.03780392,0.017407324,-0.023901775,0.06551919,-0.0058328644,0.0014592357,0.023211928,-0.07724064,0.040354513,0.03510157,0.014590423,0.034747712,0.04608476,-0.07602454,0.013177817,0.055012073,0.030862657,-0.088901825,0.026799282,-0.06310667,-0.011491041,0.0622406,-0.08105548,0.016111614,-0.014857753,0.005796523,0.011759432,-0.06985756,0.014483081,-0.051673017,-0.0022559608,0.06099601,-0.03565407,-0.006412972,-0.051338337,-0.03443221,-0.060482588,0.037533246,-0.011891423,-2.8075911e-08,-0.02472989,-0.041166224,0.018781455,0.0045751887,-0.057007946,0.050709922,-0.018891415,0.0022321471,-0.023741296,0.099000715,0.013287229,0.0468108,0.026517173,-0.029071845,-0.04778488,-0.028834496,-0.041582663,0.04850458,-0.025940511,0.015661245,0.02968439,0.028160619,-0.047316417,0.006554991,0.055803344,-0.046846144,-0.032801714,-0.10474267,-0.074194334,-0.062158093,0.031626783,0.014587054,-0.044544112,-0.047413774,-0.043623455,0.008927757,0.035231203,-0.021834897,-0.022608513,-0.022950117,-0.038158078,0.030555267,-0.07823937,0.018389167,0.063545406,0.037732538,-0.04244553,0.10088392,-0.04026197,-0.03557777,0.034687813,0.030591402,-0.007466714,-0.029015088,-0.07814567,0.06120946,0.016170198,-0.017262831,0.025474269,-0.052742615,0.006109578,-0.09436796,0.0071099596,-0.04572502 +1.8.99.2,An iron flavoprotein (FAD). Methyl viologen can act as acceptor.,384,1.0,-0.029448882,-0.037177835,-0.10279096,0.068842225,0.11137786,0.04721362,0.037929557,0.026452783,0.019597221,-0.08200449,0.030856704,0.006471358,-0.044614185,-0.0414814,-0.036088273,0.013156634,-0.017167674,-0.004538376,-0.04227046,0.044508394,-0.0275175,0.007293633,0.032956347,-0.08761835,-0.085946985,0.049418032,0.011633592,0.017355718,0.0494933,-0.00033636813,0.02040732,0.085207336,0.049876984,0.04477025,-0.05342199,0.007934135,-0.00037546686,-0.046452224,-0.0847277,-0.018516922,0.0307655,-0.012351215,0.04626214,-0.016254766,0.044926267,-0.035287824,0.038659617,-0.000105419036,-0.012485108,0.061924156,-0.025945503,-0.053785097,-0.04800667,0.058953866,-0.04319457,0.051788088,-0.027427826,-0.10222236,-0.024510307,-0.001543026,-0.0115677295,-0.07191052,0.015355051,-0.03966397,0.027355513,-0.03717465,0.013964958,0.008499286,0.02848879,-0.05203747,0.012325098,0.012567498,-0.1333214,0.06961304,-0.0027440765,0.107725985,0.005946933,-0.050830953,0.118325084,0.015581077,-0.013013862,0.008517086,0.11220272,0.06628027,0.0648068,0.012853619,-0.015129086,0.008307986,-0.03558466,0.10575051,-0.046152942,0.032943945,0.04890071,0.007554293,-0.0074024154,0.03589609,0.079900496,-0.05922868,-0.025807153,0.021390537,-0.08927461,-0.0068130004,-0.02788798,0.008097399,-0.043120023,-0.015900327,-0.019087382,0.08039154,-0.056668334,-0.05433441,-0.0069982656,-0.03885415,0.09509147,-0.07831769,0.026983878,0.02464753,0.024516212,-0.04920812,-0.002488135,-0.05004717,-0.019632388,0.098706365,0.04257508,0.025395606,-0.019324364,-0.018147942,-0.041739427,1.1160435e-33,0.010749533,0.02272946,0.009689521,0.019571546,-0.025237622,0.067187235,-0.052676637,-0.00700899,0.014617961,-0.05364316,-0.07259366,-0.07944966,0.060990132,0.022062404,0.002698031,-0.011566303,0.013770597,-0.04410179,0.050477337,-0.14233851,0.043153226,0.086838,0.016918618,-0.018550519,-0.08694356,-0.012704048,-0.046393976,0.017170267,0.036781505,-0.00587624,0.01679158,-0.023697203,-0.033216566,-0.020192774,0.015133106,0.09381687,-0.025009245,-0.049782604,-0.09335335,0.049978938,0.054525778,0.009832858,-0.12158294,0.020045701,0.057780866,-0.05670454,-0.08782573,0.01893195,-0.06473942,0.0557816,-0.023993341,0.016027175,0.026453521,0.017751608,-0.13671012,0.0116665065,0.022281956,0.04529444,-0.063088454,0.014192098,0.0015303615,0.015805122,0.025055978,0.11335452,-0.05061655,-0.028325142,-0.041358467,-0.053100467,-0.055169124,0.09231557,0.052227434,0.023553599,0.09628918,-0.035642706,0.029349294,-0.08568359,-0.1096646,-0.06740774,0.026270857,0.018182721,-0.08482928,0.007459487,-0.023600856,-0.0022938142,-0.07834156,0.002141145,-0.010825302,-0.0579506,0.045893483,-0.075228564,0.046037633,-0.030713808,0.03098171,-0.005349605,0.036752407,-1.8095966e-33,-0.005811316,-0.055057388,0.033680834,0.08119861,0.026698083,0.061658077,0.047241665,-0.08925646,-0.01561798,-0.04147382,0.08709773,-0.065957464,-0.013663192,-0.011899406,0.004313715,0.06455655,-0.035144925,0.056663424,0.040043656,0.031031452,-0.06839249,-0.052117262,0.045908157,0.1203793,0.032928336,-0.006144651,0.031440265,-0.046674173,-0.018597279,0.08531466,0.0066471603,0.056489307,-0.05100092,-0.062351856,0.004182886,0.022980656,0.017398212,-0.042237133,0.0042745383,0.024942148,-0.038330484,-0.00678458,-0.0036414163,0.11090127,0.038838614,0.07434663,-0.02338101,0.04337962,0.031942282,-0.05685386,0.027538914,0.020451497,0.009335618,0.09617792,0.09047467,0.042696647,0.057359368,0.035786703,-0.0033612833,0.06453692,-0.021169413,-0.05096739,0.022961674,-0.017761905,0.0871506,0.042522885,0.0685512,0.11320037,0.024166841,-0.051145848,0.14060529,0.049415708,0.043382887,0.03924679,0.078323565,-0.078716695,0.02846144,0.06621891,-0.08143634,0.0072332146,-0.033401832,-0.031891357,0.006903877,-0.006850541,-0.07782968,-0.104739115,0.006327967,0.017805543,-0.029975504,0.040557664,-0.06323649,-0.010365206,-0.034472987,-0.055143222,0.015999898,-2.5164718e-08,9.456801e-05,-0.08607494,-0.024181552,-0.063627146,0.028422955,0.06522576,-0.05420448,-0.052713607,0.02193471,0.03587395,-0.012937046,0.073149875,-0.00091097155,-0.021182887,0.044065423,-0.04398763,0.0011382909,0.05929313,-0.034173302,0.017116182,-0.0736,0.050711796,-0.0048469156,-0.031112203,-0.025017895,-0.027440354,-0.038776428,-0.014607815,0.062343366,-0.02063603,0.017550794,0.027926208,0.0157872,-0.034504224,-0.13798869,0.06261825,0.11566171,-0.048970595,-0.035087083,0.057375945,-0.0069118114,-0.04104011,-0.05373689,-0.060256496,-0.025145551,0.014725677,0.017986376,-0.0142494,-0.033396874,-0.055571374,-0.009512378,0.014288402,0.03632551,0.03460539,-0.083144024,0.021739407,-0.0068537486,-0.03433957,0.018110909,-0.08150897,-0.011417555,-0.027793126,0.07855907,-0.020900518 +1.8.99.3,Methylviologen can act as acceptor. A group of sirohemoproteins containing iron-sulfur centres (P-582).,384,1.0,-0.0006900288,-0.075174116,-0.08614749,0.054768298,0.05994041,0.041797522,-0.013301872,-0.030461755,-0.0031823663,-0.028823016,0.04672687,0.015947334,-0.0061154165,0.02601538,0.017305702,0.09724122,-0.10947203,-0.036493003,-0.018567966,0.03556005,-0.01149886,0.05183687,-0.0042685973,-0.060975917,-0.06834586,0.06611746,-0.0034490786,-0.0047201733,0.027999548,-0.04532767,-0.0057730973,0.016050236,0.061737712,0.056160126,-0.033040877,0.05078659,-0.013549911,0.023834782,-0.08484261,-0.07544204,0.046075005,-0.05664055,-0.013779705,-0.055140693,-0.049488865,-0.059574377,-0.0045139743,0.015390906,0.009903428,0.043888252,0.006019813,-0.04319571,-0.005083313,0.090098664,-0.020547058,0.040681716,0.006042219,-0.06955977,-0.0007699776,-0.0852509,-0.011830481,-0.038592853,-0.042741895,-0.029132413,0.030087128,-0.054086052,0.08701351,-0.016839534,0.029550873,-0.022237562,-0.0018451774,-0.011666459,-0.036217786,0.054523427,0.03991373,0.09761904,0.016682401,-0.08096543,0.13230865,-0.03497353,-0.025483085,0.021176804,0.11231282,0.0729574,0.08291278,0.0029696398,-0.08892146,0.05416521,-0.072761945,0.014249349,-0.049230076,-0.04147599,0.040967952,-0.03610193,0.028136805,0.017139032,0.023308052,0.02458664,-0.0603719,-0.0056654625,-0.04013874,0.034759264,-0.13758385,-0.07414105,-0.050973408,0.035758115,-0.030487675,0.037348624,-0.016861932,0.0040808576,-0.02638159,-0.069869906,0.08317759,-0.04016754,-0.00597751,0.034302063,0.06241423,-0.00386337,-0.06906298,-0.04870382,-0.07973427,0.10573187,0.050543208,0.007359178,-0.009737272,-0.012259266,-0.10234571,-3.2209672e-34,0.056740183,0.035066,0.03974375,-0.023343353,-0.021055937,0.029264288,-0.046461638,0.023600709,0.082476005,-0.10462105,-0.06419046,-0.109347,0.05863604,0.0018330413,-0.015839579,-0.022557696,0.016333936,0.043946538,0.059110917,-0.12615725,-0.056382228,0.11934073,-0.005939954,-0.04469901,-0.038149577,0.02787304,0.007872287,0.015739545,0.042290796,0.006333093,0.030889768,-0.06256051,-0.09039183,0.008447003,0.036369167,0.092265055,-0.020286363,-0.015677905,-0.09255921,0.009133844,0.0035020213,0.0020085236,-0.07919416,-0.019601101,0.010182547,-0.027630365,-0.07321477,-0.031649824,-0.060344305,0.06312565,-0.042744864,-0.023911396,-0.013918357,-0.022354888,-0.064698435,-0.05550465,0.03472907,0.023101928,-0.009161383,-0.0037087526,0.020712681,0.0055226814,0.013504963,0.057538103,-0.012861218,-0.030509613,-0.07364941,-0.022071619,-0.07367859,0.12556283,0.023942694,0.035998315,0.09145176,0.030608796,0.011935091,-0.026140455,-0.08084277,-0.026280094,0.018401105,0.054243833,-0.033401087,-0.059955068,-0.081783086,0.030250985,-0.084725305,-0.009812356,0.061691564,-0.09176417,0.01086312,-0.061157793,0.03162848,-0.066277556,-0.02130245,0.03853017,-0.017762605,-2.0484176e-33,-0.016794702,-0.04363873,0.055363208,0.023310727,0.005705919,0.063015595,0.055005535,-0.021467011,-0.033805855,-0.0815964,0.12567253,-0.0049255677,0.03156644,-0.024833852,0.03674838,0.03510478,0.00034563986,0.06671847,0.033394627,0.040113557,-0.014460361,-0.0085159,0.0049248165,0.14511302,0.043199826,0.015139854,-0.004383661,-0.040069144,0.1022392,0.08321773,0.00045892785,0.06479202,-0.07291259,-0.09272937,0.015704606,0.009572958,-0.049977954,-0.00083002367,0.007516241,0.017195871,-0.035231274,-0.008012797,0.006644818,0.12606403,0.06953606,0.042705186,0.008085278,0.011815211,0.023651622,-0.04556855,0.016850768,0.02893717,0.023135621,0.092301644,0.075811125,0.05122881,0.037757557,0.0010968406,0.010055373,-0.005574584,-0.07644329,-0.041256953,-0.023833567,-0.0037146665,-0.02255339,0.074359685,0.02745048,0.047174852,0.034262113,-0.06239097,0.042185403,-0.04672701,0.09148868,0.032180797,0.051432095,-0.10199865,-0.0005173644,0.010836532,-0.06833148,-0.005402809,-0.062874705,0.01518299,0.011162657,-0.024028203,0.031971764,-0.11060705,0.031170385,0.033096865,-0.060117587,0.026010236,-0.05088553,0.05787396,-0.06316688,0.03165802,0.015268248,-2.9524534e-08,0.012333129,-0.12250961,0.06895225,-0.06969884,-0.006935673,0.07154674,-0.060039353,-0.043999612,-0.008749709,0.046874817,0.07685267,0.059305213,-0.020346083,-0.0095246285,0.067886226,-0.021682823,-0.0042620585,0.06563008,-0.0054007275,-0.041988052,-0.09970624,0.008029208,-0.004990967,-0.028984971,-0.013194788,0.011289357,-0.013958152,-0.030872425,0.010918738,-0.026239999,0.031508528,0.07138814,0.004954069,-0.009392785,-0.044411708,0.06709745,0.06381545,-0.06036881,-0.017530084,0.035369284,0.0029179482,0.014517157,-0.06346306,0.013644031,0.023839097,-0.02244799,0.013848802,0.068046875,-0.065432146,-0.028747082,-0.004847075,0.0037793287,0.061872054,-0.034888525,-0.08754042,0.060572546,-0.022413483,-0.09841047,0.06089319,-0.042328447,0.039084543,-0.05921785,0.08550828,-0.008591448 +1.9.3.1,"An oligomeric membrane heme-Cu: O2 reductase-type enzyme that terminates the respiratory chains of aerobic and facultative aerobic organisms. The reduction of O2 to water is accompanied by the extrusion of four protons. The aa3-type enzymes of mitochondria and many bacterial species are the most abundant group, but other variations, such as the bacterial cbb3 enzymes, also exist. All of the variants have a conserved catalytic core subunit (subunit I) that contains a low spin heme (of a- or b-type), a binuclear metal center composed of a high spin heme (of a-, o-, or b-type heme, referred to as a3, o3 or b3)-iron, and a Cu atom (CuB). Besides subunit I, the enzyme usually has at least two other core subunits: subunit II is the primary electron acceptor; subunit III usually does not contain any cofactors, but in the case of cbb3-type enzymes it is a diheme c-type cytochrome. While most bacterial enzymes consist of only 3-4 subunits, the mitochondrial enzyme is much more complex and contains 14 subunits.",384,1.0,-0.06396038,-0.06077924,-0.103759065,0.0023399156,0.052007858,0.0001331373,-0.036854096,0.048789967,0.046900176,-0.06492895,-0.05722302,-0.04513893,-0.036256604,0.016205756,0.015048155,0.02702833,-0.058092613,0.02094446,-0.06273064,-0.05854014,0.00023401128,0.036704414,0.020155398,-0.0040111844,-0.0144459205,-0.0068754586,0.0569046,-0.061810672,-0.07873674,-0.081794694,0.0008659138,-0.032927107,0.09827082,-0.04737724,0.109675564,0.04095021,-0.06742437,-0.044917792,-0.0542925,-0.042792913,0.033651136,0.097691335,0.033328857,0.032272335,-0.026915733,0.031214412,0.07483096,-0.017898923,0.03380019,-0.04522773,0.013549335,-0.057571005,-0.078850456,0.12594716,0.040361684,-0.013781523,-0.042934053,-0.053949635,-0.0024271172,-0.018494586,0.01304008,0.012505751,0.014128411,-0.029226441,0.060962345,0.0021611368,0.029256694,-0.08373909,0.008536006,-0.060523372,-0.033367895,-0.056391064,-0.07984384,0.031984426,-0.027932575,0.04346549,0.101725,-0.015885154,0.03443181,0.008689127,-0.04551024,-0.0017879461,0.060641263,0.1184816,0.04969617,-0.024009546,-0.0031305363,-0.033640485,-0.060776856,0.050787944,-0.016545594,0.061876386,-0.006447764,-0.07112922,-0.048574623,-0.016641473,0.06587905,0.11357129,0.008493901,-0.021666404,0.04514461,0.083257295,0.054412402,-0.06416241,-0.026397042,-0.060685646,0.083926216,0.088365875,0.05407372,0.031199262,0.07144803,0.018968672,0.024869747,-0.028850615,-0.017378146,0.016762331,0.057004783,-0.040406477,-0.023366954,0.08301794,0.030409088,-0.00887647,0.06085567,-0.061975915,-0.036530986,-0.016448008,-0.11329119,2.2503201e-33,-0.0123843895,-0.011428194,0.0153602725,-0.017477918,-0.014617604,-0.026711568,-0.11025115,-0.033389803,0.008536673,0.02757687,-0.07773481,-0.051718272,0.047128357,-0.010337072,0.01749425,-0.08436201,-0.0686338,-0.020659113,-0.007539709,-0.009271203,0.050436478,0.060701575,-0.027552295,0.010317874,0.084288,-0.044198077,-0.006591122,-0.046841174,0.005222884,-0.008838248,0.07853845,-0.10429945,-0.12186111,0.0037244798,0.018095342,-0.03140778,-0.03353054,0.03468482,-0.029385407,0.023599107,-0.027808128,0.026805013,-0.031906053,-0.012934848,0.11123974,-0.09151255,-0.040998608,0.069410786,-0.0034335938,0.020117681,0.043905966,-0.03911724,0.12603629,0.0024730302,-0.0009448252,0.0028595983,0.03135067,0.077276446,0.03385694,0.054391973,0.11720256,0.094228625,-0.09941233,0.064394765,0.013219142,0.04543559,-0.05487779,-0.017840765,0.022379287,0.073433846,-0.060950484,-0.037040476,0.06369165,-0.010975419,-0.0020576946,-0.02942213,-0.04659358,-0.043332558,0.047124695,-0.013998476,0.013460703,-0.027329216,0.072710425,-0.021303875,-0.088016294,-0.021415811,-0.026581166,-0.0055194083,-0.049868003,-0.026022125,0.07038562,-0.05002012,-0.039290167,-0.02848088,-0.026746348,-3.3468532e-33,0.06387118,-0.0743528,0.09025539,-0.13247308,-0.018133258,0.07616524,0.02989657,-0.0342558,-0.014242682,-0.07218849,0.10248048,0.00916313,0.0041182637,0.027497448,0.05120149,0.0019259702,-0.10733243,0.0345469,-0.006281021,0.019795882,-0.021470346,0.016935531,0.00063212257,-0.017860046,-0.037009217,0.014754533,-0.028069355,0.032534976,0.122741885,0.022591498,-0.047041006,0.087681375,-0.012147799,0.018186051,-0.10784369,0.024934778,0.0043854085,0.0001704025,-0.0086586885,0.04228637,-0.010267853,0.023410587,0.041308507,0.0037654515,0.03399896,0.09554877,-0.09017855,0.0062412624,-0.047111686,-0.020303044,0.006915701,-0.0133704515,-0.049762066,0.03125804,0.05801866,0.0051197726,0.02647555,-0.067865945,-0.034683637,-0.056950565,-0.016792715,-0.037633166,0.113476045,0.033440467,-0.018524138,0.017569805,-0.027199747,0.059469372,-0.014630766,0.0062999264,-0.030839974,0.055606492,0.01511269,-0.047472607,-0.0028867174,-0.004048947,0.019988699,0.041054998,0.021051526,-0.0052927677,-0.030132564,0.06238824,-0.016241867,-0.04351353,0.065049194,-0.06817453,-0.014813743,0.07423191,0.022087898,0.022090428,-0.02547003,-0.04863803,-0.012005619,0.09872586,0.003300557,-4.8212716e-08,-0.009207878,-0.039283834,0.055045888,-0.029218867,0.0027480891,0.0361979,0.027433632,0.0028260911,0.03662446,0.033645898,0.012493124,0.07253568,-0.04467968,-0.08470155,0.06765578,0.08635838,-0.043463983,-0.055886615,0.04693889,-0.025094297,-0.013783298,-0.026375493,-0.06940817,0.08917959,0.024927732,-0.045272764,-0.09883481,0.008142614,-0.04589801,-0.011095699,0.010018066,0.059439138,0.057577185,-0.052505184,-0.082422785,-0.062358815,0.010006943,-0.03682953,-0.07878629,0.058136597,0.03328156,-0.043127462,-0.09590787,-0.02507455,0.053196207,-0.022743823,0.002700845,0.066022694,-0.025068684,-0.03266534,0.012640068,-0.03224507,-0.009248993,0.016784666,-0.09724296,0.083403364,-0.031070055,-0.07599278,-0.016318815,-0.0032831668,0.09813916,-0.018781034,0.10388266,-0.010349101 +1.9.99.1,An iron protein.,384,1.0,-0.030547986,-0.03268735,-0.05595656,0.15550317,0.0442354,-0.007506916,0.1622413,0.058103777,0.016559854,-0.058792975,0.0030690578,-0.008893409,-0.075591646,0.017419748,-0.03966154,-0.052111983,0.04198234,-0.025664162,-0.058964368,0.0068538054,0.0027510147,0.04255883,0.006320065,-0.002107357,-0.08329024,0.03714809,0.048363067,-0.026688123,-0.05226514,-0.030014912,-0.020868955,-0.051098548,0.01299584,-0.013005335,0.010010474,0.03439715,0.019343158,-0.08804186,-0.03796503,-0.02848354,0.025082355,-0.04318314,0.011232076,-0.04563005,-0.03692763,0.01863868,0.060054123,0.045620862,0.08031214,0.10587497,-0.06848729,-0.08225148,-0.04627238,0.015060828,0.0038270317,-0.02178657,-0.012633058,-0.05860608,-0.07301761,0.024823286,0.009839735,-0.034348264,-0.036547344,0.0227835,0.1067995,-0.063182995,0.032347493,-0.016381796,0.017907739,-0.0378191,0.044491664,0.037264176,-0.07401127,0.055130348,0.01575915,0.011436892,0.024796715,-0.05587558,0.13305157,0.04799229,-0.046305284,0.029927505,0.012773555,0.08654123,0.05077902,0.040816944,0.035724293,-0.022354916,-0.09736554,0.03525654,-0.02456924,0.02693569,0.0061639952,0.0027245763,-0.0010393744,0.03241702,-0.02799546,-0.011196223,-0.060391255,0.073171824,-0.052279893,0.056657,0.026916659,-0.043743324,-0.01301581,-0.028008236,-0.075971425,0.102866225,0.056486934,0.029414296,0.011236396,-0.003523678,0.031656995,-0.011495763,0.021672964,0.041508224,0.082971364,-0.013394809,-0.052017406,0.05855747,0.044709805,0.042282853,0.00992665,0.061418083,-0.05460479,-0.033508003,-0.055620875,-6.0478332e-33,0.009801702,0.03302355,0.07308017,0.0717402,-0.045413457,0.035399396,-0.08529944,-0.03877216,0.019198408,0.0415423,-0.07346607,-0.035902135,0.053019505,0.019096645,-0.0100326445,-0.10571655,0.0004975177,0.004095414,0.07439895,-0.0051826136,-0.016483264,0.12595978,0.10053588,-0.02218163,-0.009802621,0.003900434,-0.06510544,-0.05278599,-0.066217005,0.020871667,-0.010348511,-0.042238563,-0.061026324,-0.05690128,0.052044537,-0.074288905,0.024347046,-0.09515657,-0.07290331,0.019256324,0.08184817,0.0010281787,-0.04921878,-0.008955797,0.041778803,-0.051745225,-0.02345346,0.062103525,-0.0760717,-0.020936474,0.042986065,0.017649999,0.09250152,-0.034169383,-0.09938647,-0.01682665,-0.005256022,0.026783396,0.0135540115,0.08293358,0.03538349,0.04738584,-0.02766189,0.110920444,-0.0063020573,-0.037647624,-0.061067116,0.0071319146,0.032809302,0.069814816,-0.02330907,0.024190528,0.11841261,-0.056769732,-0.044209834,-0.059741467,-0.10412704,-0.018279396,0.03801016,0.042277716,-0.021437796,-0.037039172,-0.018398965,0.010685505,-0.09204458,0.065621614,-0.015064733,-0.0075299703,0.08099413,-0.079396814,0.0037960778,-0.030279603,-0.026987076,-0.060794983,-0.036137894,3.25156e-33,-0.00015605334,-0.07774647,-0.017012445,0.08494499,0.035413973,-0.017252456,0.010733522,0.00010921009,-0.0657,0.053086944,0.13044572,-0.09169637,0.048356853,-0.0667507,0.07963411,0.14878677,-0.076970205,0.04065113,0.09508405,0.026172925,-0.09290007,0.00073548703,0.0716238,0.046538822,-0.01800282,0.060221285,-0.03058381,-0.05653826,0.006511485,0.075865515,-0.028235255,-0.031092253,-0.0037305208,-0.13466857,-0.06996982,-0.0032241652,0.057824895,-0.04966594,0.0364994,-0.018577367,0.046073556,0.0005558244,0.05080373,0.13955006,0.026521984,0.0026292552,-0.039472908,0.009942361,-0.012719961,0.04213727,0.050094794,-0.066648014,-0.02863319,-0.0040481933,-0.02979368,-0.023425626,-0.025050394,0.04482483,-0.027972117,0.115378596,-0.021861667,-0.019194547,0.07146641,0.065466635,0.038437363,0.032645747,-0.03750081,0.0140900165,-0.031438697,0.0074316496,0.0998737,0.047383063,0.06459466,-0.029312909,0.054895923,0.002885127,0.016903544,0.038604148,-0.048839252,0.049689915,-0.11545964,-0.045598958,-0.017762046,-0.0047896784,0.050341357,-0.06856544,-0.0003149344,0.009648166,-0.03239399,-0.022178855,-0.06619679,-0.06597968,-0.05316923,0.01973258,0.0031741718,-1.2778442e-08,0.010725331,-0.04179835,-0.029455876,-0.067830175,-0.005872341,0.020825097,0.001838066,-0.085639216,-0.013044954,0.022963153,-0.012202513,0.10366144,-0.0036974312,0.024328334,0.017121114,0.0022789757,-0.020842846,0.052050963,-0.022122433,-0.011968845,0.008456651,0.022542236,0.067895524,0.0015558144,-0.03595551,-0.06570697,-0.04500874,0.015109252,0.024354307,-0.006388884,-0.03331594,0.055960137,-0.026549146,0.010442001,-0.06346821,-0.004715345,-0.008321135,0.0033110196,-0.07312384,0.009063667,-0.06763877,0.017750904,-0.06699612,-0.026215198,0.008498962,-0.027425637,-0.048921864,0.039026536,-0.03191648,0.021714957,0.04802261,0.018943755,0.065556645,0.023598526,-0.0036381017,0.038427502,0.007216478,-0.08516541,0.00024349778,0.009282982,-0.024277324,-0.059714332,0.042911,-0.0397725 +1.10.1.1,Some preparations also utilize NAD+.,384,1.0,-0.066306435,0.029219715,-0.07003334,-0.0048755007,-0.0407586,0.029560816,-0.059886206,0.0576244,0.0075689284,0.03462904,0.0051114336,0.032246888,-0.050721243,0.0527591,-0.00012351271,-0.01996151,0.0501137,0.033449546,0.054476988,4.7456153e-05,0.022672666,-0.029170588,0.041967586,-0.020668376,0.064161696,0.02341758,-0.048763264,0.02365251,0.10778593,-0.05783057,-0.03630894,0.0650152,0.0017900178,-0.078544535,-0.0918363,0.054524638,-0.069481745,-0.0063103344,-0.0438493,0.036306687,0.02336516,-0.055488005,-0.05920056,0.061803468,0.025340937,-0.074627005,0.00053179776,0.04128914,0.034595806,0.017238785,-0.02390192,-0.04064501,-0.024896195,-0.016822828,0.042342808,-0.042496357,-0.040326867,-0.03652327,-0.03192046,-0.033714186,-0.052747242,-0.04384489,-0.08644969,0.033884957,0.037023954,-0.028107371,0.075992696,0.010579643,0.05761697,0.011000062,-0.103774026,0.030633314,0.035417978,0.026784196,-0.044651706,0.08743081,-0.049787976,-0.076173626,0.04813436,0.0028980076,0.055476107,0.08878139,-0.052853316,0.024991944,0.089285776,0.11618387,-0.01972268,-0.025010554,-0.025755335,-0.014453875,0.06460292,0.01030745,-0.024466367,0.04944698,-0.14081769,0.028807646,-0.018694859,0.008582216,0.020017648,0.003524855,0.022560723,0.059579268,-0.035523597,-0.06709515,-0.076899625,-0.03468402,0.023829175,0.07234293,-0.037901346,0.02611231,-0.04860999,0.02109814,-0.0019728963,-0.025089907,-0.07300107,0.17061993,0.022557413,-0.0019169378,-0.04492816,-0.010445338,0.016683906,-0.005884361,0.009027557,-0.041321374,-0.0073222998,-0.014480484,0.002272318,-3.8583666e-33,0.08499692,0.017033502,-0.031514525,0.12596305,-0.009693382,0.08287506,-0.08176187,-0.018934984,0.018666003,-0.06585347,-0.025970573,-0.07967131,-0.0034829604,0.024286142,0.0016808534,-0.027953196,0.028179375,-0.0021234027,-0.0071089393,-0.0231869,0.03312416,-0.015260491,-0.0060438896,0.039114986,0.052678507,0.08112452,0.03908154,0.018715406,-0.030639078,-0.002490487,0.061500292,-0.06776128,-0.13864195,0.013474165,0.0028237866,0.097518645,-0.069795735,-0.051358294,0.050351884,0.05030017,-0.06954614,0.0882298,-0.0050526797,-0.036074124,0.021775154,-0.084902786,-0.048710212,0.088142715,-0.00044052242,0.021107163,0.03975697,0.03682177,0.07013308,-0.021800762,-0.007420361,0.0917068,0.029636323,-0.040722635,-0.0024300271,0.13263234,-0.016260862,-0.0024155336,-0.06028042,0.07544526,-0.10905488,0.027199924,-0.11318254,-0.09421117,0.035255887,-0.013836059,-0.03598683,0.005301589,0.051196687,0.011410001,0.012527872,-0.03747739,0.050417345,0.0064726826,0.044746403,0.014237014,0.032186892,-0.04475833,-0.05536544,0.038899876,-0.014786521,0.020766953,0.0028043182,-0.0074561983,-0.013895213,0.046332132,0.010859909,-0.0637519,0.014655252,-0.06909321,-0.008813964,1.6079721e-33,0.07310353,-0.018221283,0.028221613,-0.011219861,0.028927092,0.067613125,0.07078264,-0.14488052,-0.015079529,-0.07559829,0.028115079,0.07083683,-0.037593663,-0.04302819,-0.0372686,-0.003720421,-0.043384515,0.006249999,-0.028473355,0.009618104,-0.010550596,0.122682884,0.09362852,-0.057781268,0.04648753,-0.0473972,-0.042524,0.03447848,-0.024193993,0.05150827,0.017535023,-0.07144527,-0.12638609,-0.054198444,-0.017039072,0.013843263,0.041795902,-0.021100458,-0.035757683,0.05820011,0.035907988,-0.006328372,-0.04988508,0.07361564,0.018692993,0.049515802,-0.04884686,-0.0627943,0.047840007,-0.029516654,0.07237971,0.005677729,-0.108990505,0.018042486,0.068483986,-0.0032205535,-0.028287962,-0.041571505,0.0025485053,0.009035051,-0.02401907,-0.010779469,0.025377374,-0.08649995,0.04390953,0.021718381,0.017779425,0.063735336,0.057184853,-0.029558776,0.0530166,0.048387863,0.012298125,-0.035587277,0.0014513117,-0.04988728,-0.04604612,-0.0076695248,-0.024861166,-0.004427757,-0.1164095,-0.033603474,-0.08050027,-0.01688116,0.052158654,-0.009087057,0.035311434,-0.044614278,-0.05414342,0.034802128,-0.024001975,0.053871248,0.043951966,0.07534072,0.006655719,-1.5728771e-08,0.016136616,-0.034584925,0.048643287,-0.016800314,-0.0057045133,-0.023455119,0.0059562083,-0.016637374,0.0027023265,0.027377145,0.06449963,0.13551447,0.10948258,0.0282973,0.0309772,8.126676e-05,-0.02104999,0.05440516,-0.1235223,-0.08112003,-0.0696716,0.023436863,-0.03826063,0.064044796,0.05402172,-0.04179176,0.072684266,-0.0035186098,0.069919355,-0.042439703,0.025122399,-0.016800085,0.07555465,-0.022338133,0.009087159,0.06591943,0.020850766,0.0637607,0.018078838,0.06591974,-0.08568573,-0.11799555,-0.022669127,0.076042,0.006457301,-0.031430062,-0.027403058,0.021875827,-0.04683857,-0.070137426,0.043929476,0.0143974265,0.024384465,-0.025096336,-0.0022487089,0.05667161,0.0058446997,-0.048712358,0.06154712,-0.036756184,0.016102148,-0.040564917,0.06094829,-0.02558388 +1.10.2.2,"The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. The mammalian enzyme contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non-cytoplasmic compartment (cf. EC 1.6.99.3, NADH dehydrogenase).",384,0.99999994,-0.103048064,-0.01225962,-0.10461703,-0.026560787,-0.008262148,-0.02735094,-0.026872883,0.027831236,-0.015079657,-0.041450996,-0.03301242,-0.07998352,0.019348415,0.026344316,-0.019410342,0.010843957,-0.07700595,-0.035733663,-0.0016706482,-0.013760024,-0.022749558,0.018064229,0.013928554,0.015864564,0.005946768,0.02342514,0.02742038,0.013402895,-0.05118912,-0.034223747,-0.0418312,-0.032960784,0.07234696,0.011219971,0.063818336,0.034946706,-0.041985102,-0.0579202,0.01932964,-0.0011553221,0.041630805,0.09427284,0.012806623,0.0016882347,-0.012152833,-0.025564017,0.0030289707,-0.042068254,0.081039526,-0.01965394,-0.012667864,-0.03401622,-0.048146892,0.11774746,0.052202836,0.008633096,-0.04382296,-0.045259453,-0.050049547,0.036806047,0.0402909,-0.019142907,0.05504211,0.018897116,0.069922395,-0.02551947,-0.013752447,-0.04575055,-0.024969531,-0.09949759,-0.08064343,-0.09801989,-0.08581535,0.016761195,-0.04431289,0.010326095,-0.012678461,-0.018973634,0.007973748,-0.02751032,-0.012506732,-0.05474734,0.012200238,0.14745435,0.016630765,-0.015637187,0.018540118,0.0071498374,-0.05960535,0.048386127,0.005692146,-0.01816585,-0.04999166,-0.01035273,-0.07898317,0.0096651325,0.036312692,0.10672668,0.056255642,-0.028492605,0.047252942,0.104080625,0.07354159,-0.08246836,-0.02550475,0.011020304,0.046098378,0.12431293,0.004913334,-0.024968995,0.0058002537,-0.011826164,0.041586105,-0.013897126,0.020994013,0.10816211,0.077803284,0.033716224,0.01728988,0.038071614,0.017151799,0.0055968342,0.078667514,-0.038738847,-0.03242462,0.002996192,-0.11600537,9.720018e-34,-0.010761911,-0.024036407,-0.029316597,0.0016273671,-0.054268323,0.022803633,-0.0553502,0.011184476,-0.027024804,0.017546872,-0.08775807,-0.031303376,0.04023051,-0.040407248,-0.035960857,0.022813393,-0.055607166,-0.044911027,0.056952573,0.0039930604,0.1066581,0.0074670753,-0.03313595,-0.08859133,0.06728707,0.062765725,-0.008613834,0.02907313,0.021976272,7.774586e-05,0.040883176,-0.11169123,-0.17560746,-0.0025083434,0.023301886,-0.002459985,-0.01578141,-0.014429908,-0.020169796,0.07244658,-0.08718697,-0.05543222,0.00937503,-0.017186038,0.04998339,-0.012300814,-0.075542524,0.013793075,0.017216016,0.01780157,0.050044104,-0.08915466,0.10982461,-0.06276392,-0.053340446,0.02566202,0.054890428,0.023214148,-0.0067112166,0.095341615,0.058375165,0.10106834,-0.059636876,0.12021728,0.07579707,0.03744086,-0.09315953,-0.001913556,-0.037945077,0.085375406,-0.074145116,-0.014606793,0.11678257,-0.044964693,0.08882339,0.0053855507,-0.095120825,-0.023418672,-0.008740892,0.0251419,-0.03019739,-0.10140202,0.030312456,0.006512971,-0.021153241,-0.003116807,0.025720153,-0.044793505,-0.023435187,0.0070293704,0.06961926,-0.022250822,-0.036506977,-0.022708315,-0.02658146,-3.421993e-33,0.08986446,-0.04601693,0.096055105,-0.15206297,-0.07001016,0.11266073,0.0599011,-0.04262757,0.026092745,0.045559775,0.07774978,0.030072693,-0.0057798903,-0.014595753,0.050088193,-0.00027429665,-0.057159457,0.025154062,-0.008310141,-0.04600538,-0.008271,0.005250864,0.0027184743,0.020865412,-0.018660877,0.0029087034,-0.0008598436,0.011032408,0.08975013,0.002716325,-0.0875276,0.0071029724,0.014625956,-0.052340403,-0.008638593,0.029389123,-0.05640112,-0.06991687,0.072218135,0.03213605,-0.052428793,0.045158707,-0.04856191,0.054392993,0.045993693,0.08357004,-0.10371096,0.006744347,0.0142560825,0.02288049,0.012977815,0.0022462027,0.00051484694,-0.02746892,0.07292348,0.03361539,0.023972899,-0.015436204,0.017458769,-0.010510201,-0.026384069,-0.07336866,0.046568815,0.037783206,-0.036594603,0.035773873,-0.035762597,0.023126563,6.0068043e-05,0.012964554,0.07470794,0.01733974,0.0017131362,0.01398373,-0.037810646,-0.005918041,0.03811154,0.043976434,0.022677112,-0.03952438,0.06990135,0.01848045,-0.01714973,-0.04483459,0.04689205,-0.11965819,-0.022889812,0.0769665,0.016154008,-0.06778677,-0.016784482,0.0774606,-0.05611836,0.017976217,-0.0050399606,-4.3592703e-08,0.014478573,-0.04129532,0.033076722,-0.028935835,0.05819838,0.038916524,-0.018284965,-0.04296412,0.039518375,0.020348962,0.0073304614,0.10566976,-0.0054253615,-0.01929336,0.01674028,0.062266603,-0.043944903,-0.075355396,0.04018018,0.025679497,-0.002399556,-0.054658454,-0.11991908,0.053683765,0.035707336,-0.089106396,-0.008365619,-0.000815397,-0.00021515734,-0.0018601404,-0.016135836,0.030655796,0.008183762,0.020815141,-0.07352792,-0.046769083,-0.039247215,-0.057970338,-0.048886117,-0.01039771,0.031400714,-0.1047878,-0.057271708,-0.007163986,0.044042297,0.0051877145,0.02146787,0.06831858,-0.032145523,-0.010280665,-0.02256527,0.005592296,0.018922351,-0.016617008,-0.06304616,0.09072934,-0.035944656,-0.08001073,-0.010113327,-0.04204672,0.049132895,0.0424152,0.13806275,-0.05521663 +1.10.3.1,"A type 3 copper protein that catalyses exclusively the oxidation of catechol (i.e., o-diphenol) to the corresponding o-quinone. The enzyme also acts on a variety of substituted catechols. +It is different from tyrosinase, EC 1.14.18.1, which can catalyse both the monooxygenation of monophenols and the oxidation of catechols.",384,1.0,-0.093406074,-0.050931606,-0.023085946,-0.011693918,0.100850575,-0.00449604,0.03052194,0.0475218,0.041590523,-0.033734065,0.038399305,-0.059700176,-0.14712697,-0.06762544,-0.08470237,0.013783416,-0.04647314,0.03913766,0.0005936402,-0.011044322,-0.007812362,-0.06630518,0.048224058,0.020079257,-0.022444235,0.07553689,-0.0054707658,0.01240048,0.01740072,-0.047637038,-0.0015599107,0.043619655,-0.008072989,0.064824976,-0.013361417,0.022477256,-8.053478e-05,-0.053688943,-0.03823007,0.044733364,0.037986018,0.020799154,0.0077948016,-0.026748152,0.06591686,-0.0761094,0.018829172,0.0075278324,0.019236634,-0.047335617,0.0016236039,-0.045715958,-0.016066423,0.058176853,0.06038015,0.02627408,-0.020491,-0.06989939,-0.029566145,0.06678457,0.016634597,0.016351977,-0.039774068,0.03064891,0.08862624,0.010915326,-0.06588733,0.006053627,0.03233151,-0.0154324025,-0.027898703,-0.03936007,-0.07668033,-0.024740959,-0.045928273,0.10451805,0.1448022,-0.023440002,0.053981524,-0.043688156,-0.018183334,0.07107881,0.0025141723,0.032464847,0.070119664,0.024497675,-0.02809959,-0.023015182,0.049975865,0.032595947,0.018252019,0.019870182,0.016769698,-0.05949819,-0.033005465,0.053263113,0.027492963,-0.011529571,-0.009183758,0.07835871,0.02628565,0.12161482,0.02383201,-0.08564483,-0.083323024,0.0658389,-0.039057717,0.04330372,0.04032729,0.011977447,-0.0017154136,-0.07170537,-0.012673136,-0.079468794,-0.027814193,0.06024927,0.0028417232,-0.034946702,-0.008537347,-0.028366633,-0.02046383,-0.032611154,-0.04218798,-0.03901255,-0.05419704,0.0037754753,0.015302266,1.7880742e-33,0.09512661,0.059771866,-0.030723086,-0.022567607,0.11149959,0.018455023,-0.021960357,0.016692504,-0.0626227,0.022547588,-0.08950685,0.0046013105,-0.033686932,-0.0211329,0.018100753,-0.062464043,-0.0912759,0.019357637,0.060093574,-0.03170324,0.05105774,0.068231575,-0.033676334,-0.005054915,0.0470885,-0.04331804,-0.062030893,-0.04019102,0.008074182,-0.011744136,0.00031405414,0.013751912,-0.03508478,-0.017466359,-0.059109963,-0.07249799,-0.01972646,-0.06478002,0.074753605,0.08503823,-0.0071295914,0.027151257,0.02084918,0.020551428,0.046392906,-0.04963572,0.016385352,0.08307153,0.024283703,-0.014931373,0.04688391,-0.032181878,0.05482122,0.021113265,-0.032967873,-0.03636542,-0.050507694,-0.0106564285,0.13639115,0.04995137,0.047818657,0.057794154,-0.0041079284,-0.0017228734,-0.010745101,0.037386492,-0.09096835,-0.016387999,0.05586947,0.09912301,-0.034213748,0.0111031085,-0.012573361,-0.011237336,0.05409178,-0.016758123,-0.08734924,-0.04036174,0.034101643,0.022949861,-0.08086035,-0.010445877,0.044130724,0.0011155581,-0.041377895,0.03155164,0.0017455941,-0.039937075,0.042155817,0.0030996713,0.019538557,0.011314008,-0.0214712,-0.03665169,0.010404056,-1.1419801e-33,0.033120684,-0.10613847,-0.10518409,-0.08571102,-0.03990812,-0.019422056,-0.013685517,0.0016323485,-0.0026308189,-0.047683027,0.08202512,-0.042555716,0.09751478,-0.088722266,0.0172131,-0.038297854,-0.09804252,0.09815472,-0.02832053,0.029867778,-0.008870771,0.021942204,-0.019885203,0.059409946,0.024166238,0.016181791,-0.08491262,0.010567422,0.05859773,0.04279763,0.0013440785,0.00044301752,0.016514957,0.06895464,0.02661525,0.106206186,0.04058188,0.007753885,0.013777515,0.059586737,-0.0032084729,0.014883308,0.029642005,0.05032106,-0.019008357,0.09603922,-0.15165195,-0.039270658,-0.04609812,-0.0060239327,0.05107211,0.028576255,-0.013273016,0.05589799,0.021925773,0.051363993,0.008109744,-0.12162308,-0.04830252,0.071921796,-0.020274445,-0.094682395,0.019833015,0.03510625,0.07247484,0.055387016,-0.08023921,0.08065493,0.013356034,-0.033562593,0.072863296,0.02737561,0.035789184,-0.021257859,0.02073764,-0.036587853,0.05081632,0.03448528,0.032933198,-0.03786607,-0.016186869,-0.0010851573,0.04381365,-0.0075478237,-0.12465458,-0.014827569,0.037198238,0.09521904,-0.031016262,0.047339406,-0.03137248,-0.04746826,-0.03377344,0.13220611,0.10122916,-3.4824776e-08,-0.008096737,-0.09194384,0.04505383,0.029668722,-0.047478016,0.039366454,0.0642295,-0.013512772,-0.006466926,-0.013789988,-0.0058210017,0.079428025,-0.011561626,-0.069266915,0.08262697,0.045858517,0.013401735,-0.014398816,-0.030432798,-0.0137827955,0.022285597,0.05339895,-0.0084996205,-0.062561475,-0.029415857,-0.039483037,-0.013477285,0.04311563,-0.10234319,0.024110692,-0.045418877,0.024751378,-0.016530782,0.010164108,0.052409444,0.057480253,-0.032385584,-0.04315776,-0.056034427,-0.05181037,-0.088321865,-0.044946842,-0.10035724,-0.03553149,1.7795546e-05,-0.033751156,0.026598496,0.039528478,0.041631754,0.040377453,0.031111745,0.059789907,0.04966295,-0.025576334,-0.096185796,0.005006434,-0.050220266,-0.019929042,-0.06837721,-0.080432616,0.05369418,-0.029256761,0.17815344,0.014768256 +1.10.3.2,"A group of multi-copper proteins of low specificity acting on both o- and p-quinols, and often acting also on aminophenols and phenylenediamine. The semiquinone may react further either enzymically or non-enzymically.",384,1.0,-0.07815289,-0.03795312,0.053893678,0.007845562,0.08026455,0.033661198,0.04711565,0.03843163,0.00081827,-0.025682678,0.04902816,-0.06235847,-0.053268336,0.0005947154,-0.019422913,0.018242447,-0.04599148,0.029905614,-0.0756252,0.0056430222,-0.035685264,-0.031946428,0.006586716,0.074800774,0.0062314766,0.036365546,0.008777225,0.03950797,-0.042244785,0.010272723,-0.032238163,0.021755483,-0.03047264,0.027051397,-0.04381865,0.055165906,-0.024909118,0.007713309,0.02255979,-0.0064082635,0.118188806,-0.025007192,-0.011329873,0.0076618865,0.076903425,-0.039970197,0.03928586,0.09316603,0.029313184,0.018015075,-0.012156429,-0.045641366,-0.048330206,0.098479174,0.025428234,0.09539341,-0.049171418,-0.056388374,-0.014340608,-0.03320483,0.013250573,-0.015971407,0.0061206957,0.03586474,0.08165116,0.05058484,-0.038823098,0.0009326474,0.02621949,-0.009283606,0.029761523,-0.057576627,-0.08444671,0.028586052,0.01746752,0.040620085,0.056495376,-0.026925877,0.028356263,-0.05211149,-0.017103178,0.05530177,0.01722734,0.022539271,0.08363017,-0.0061371275,0.03139919,-0.005643305,-0.030089384,-0.057868052,0.028765503,0.020967035,-0.029429454,-0.07256552,0.0015717584,0.03688689,0.046333067,-0.06445618,0.020414349,0.024763837,0.04169372,0.04176789,0.024072664,-0.118480906,-0.06298197,0.073627576,-0.114821404,0.0048119077,-0.06575459,-0.014750191,-0.033514466,-0.05310689,0.04717863,-0.060943715,0.017126257,0.049653105,-0.022562334,0.025861407,-0.061186165,-0.04491887,-0.06075344,-0.002936192,0.037677053,-0.04130312,-0.026255507,0.01701903,-0.056991193,2.0089373e-33,0.06021622,-0.027762013,-0.0056870976,0.008679131,0.06558628,0.02102709,-0.056497335,0.074539974,-0.07392987,-0.055046495,-0.020587388,-0.021850998,0.056655083,-0.0051792585,-0.0018316157,0.0076410086,-0.027299464,-0.04570272,0.078265764,-0.05283442,-0.104841426,0.10462559,-0.06115295,-0.04588893,0.015583632,-0.033918962,-0.039290644,-0.022140425,-0.028329896,-0.023804912,0.019637387,-0.041787077,0.027152432,-0.04010414,0.016701572,-0.03569919,-0.03063769,-0.04862915,-0.0197698,0.06150564,-0.0063326345,0.041263636,-0.0076133623,0.0067044282,-0.0068185437,-0.056918196,-0.02082105,0.061430946,-0.042909913,0.0044605946,0.06417564,-0.013711054,0.043035947,-0.05205452,-0.09306579,-0.0154953925,-0.029890984,-0.02498333,0.0386521,0.0130979,0.0032434193,0.042799033,-0.047480103,-0.03281015,-0.004680238,-0.014294602,-0.06382416,-0.01798916,0.014737804,0.06988704,-0.05873014,0.030272888,0.004362821,-0.08319202,0.05956979,-0.03536473,-0.06972623,-0.07113554,0.0062970673,0.05232605,-0.08013449,-0.00068077847,0.068954095,0.037154354,-0.045489095,-0.09644972,-0.005585866,-0.011972423,0.0038264089,-0.040112566,0.09979901,0.026852872,-0.05497503,-0.07720114,0.030413518,-2.5923004e-33,0.00809322,-0.10759179,-0.040875178,0.055535827,-0.04068835,-0.00939888,-0.021798592,-0.005674032,0.05940843,0.0039751576,0.1222176,-0.023826059,0.058532666,-0.05817621,0.06406054,0.0082194945,-0.0998203,0.143325,0.07390136,0.037628956,-0.007611293,0.044005215,-0.0033068957,0.040440585,0.04007343,0.06506079,-0.09891522,0.004353611,0.030346613,0.086390615,-0.0064931246,0.017329033,-0.044640165,-0.007339219,-0.0070966794,0.044932686,0.050937828,0.028708687,-0.03750538,0.007139467,0.061486863,0.05008495,0.045989826,0.023058513,0.0024195176,0.065284714,-0.07499209,0.03507928,-0.123116575,0.047366936,0.07556395,0.02576713,-0.0173655,0.04359978,0.039567724,0.038148493,-0.013875753,-0.07103716,0.01381215,0.011171528,-0.041424986,-0.122779444,-0.018092727,0.019802775,0.013901751,0.039981145,-0.07522912,0.060654063,0.0505418,-0.07617305,0.07115182,0.04091442,0.018327067,-0.0013539775,-0.020438083,0.02333876,-0.02503377,0.006062863,0.03705975,0.08737519,-0.027492993,-0.053770278,0.018369896,0.031723857,-0.078314595,-0.053753715,-0.063598774,0.13476582,0.018690975,0.014774401,-0.002640648,-0.028565062,0.003996252,0.120337345,0.09334318,-3.1271913e-08,0.03910778,-0.03893533,0.08298373,-0.018587228,0.0018403555,0.021633899,0.04604495,0.016917072,0.035405688,0.047561835,0.026087563,0.025308205,-0.028340105,-0.03804068,0.07821318,0.11338879,0.051316265,-0.0112892995,-0.03905126,-0.03240596,0.00995948,0.0386109,-0.053991996,-0.028538361,-0.0016119377,-0.08834993,0.07769752,0.083246075,-0.13098577,-0.026697058,-0.020025311,-0.06655729,-0.058680546,-0.038195614,-0.051785104,0.06921008,-0.026589427,-0.028692942,0.021219185,-0.044034816,-0.11765724,-0.06216173,-0.111453444,-0.001547588,0.050726857,-0.08685585,0.065806724,0.020675836,0.025632601,-0.046929944,-0.0013043259,-0.008085725,0.114247985,-0.104011044,-0.08699143,0.08956286,0.036933556,-0.018808335,-0.029854504,-0.082371,-0.0121204145,0.0066157947,0.13446453,0.017833486 +1.10.3.3,A multicopper protein.,384,1.0,-0.082302816,-0.11105399,-0.06972083,-0.016791694,-0.0321616,-0.031776838,0.06453635,0.062505014,0.021216966,0.0014586386,0.05814375,-0.036357887,-0.07446815,0.03898469,-0.038094137,0.034587234,0.012251615,0.031467248,0.004528458,-0.062055804,0.021483907,0.044056356,0.0047265897,0.026613286,-0.031149456,0.014965544,-0.045215916,-0.025582222,-0.03515725,-0.09914974,-0.013280918,-0.050192073,-0.04583688,-0.0046326653,0.06278524,0.00477349,-0.002520202,-0.071088836,0.040343896,-0.0041973162,0.08082696,-0.0007602941,0.04847644,-0.07752251,-0.04394469,0.056230225,-0.098921426,0.08614717,0.0952854,0.0006187141,-0.01721522,-0.11874618,-0.04823124,0.026633086,0.078227565,0.04732865,-0.12920609,-0.04077851,-0.03736348,0.011528064,-0.00024079725,0.049036246,0.026121028,0.009153813,0.14533684,-0.09947139,-0.03187717,0.0026240768,0.029521847,0.056928545,0.042817704,-0.04971154,-0.0009602409,0.05364152,0.022018945,-0.008336712,0.0012625187,-0.032417282,0.080354616,0.04252787,-0.01837527,0.06719451,-0.022891147,0.052157957,0.024984285,-0.022513146,0.016254222,-0.00903508,-0.03741963,0.014829505,0.0027656176,-0.041577082,-0.00020306169,-0.029757954,-0.06390109,-0.01321317,0.0036582083,-0.026132144,-0.022795048,0.017619701,-0.0010707387,-0.019604042,0.14026788,-0.11670749,-0.028078854,-0.055806085,-0.036218915,0.044283193,0.10528697,0.014462426,0.007237022,0.03712858,0.00060554355,0.0067577246,-0.038510054,0.06033281,0.011776482,-0.032925937,0.009655672,0.016699525,-0.053793587,-0.070249625,0.0074959053,0.023104198,-0.0237946,-0.008488803,-0.04113624,-4.6414552e-33,-0.004670381,-0.0730689,0.06907256,0.117036805,-0.003378844,0.042869117,-0.05336282,-0.021106042,-0.02252702,-0.051447563,-0.04582441,-0.0334889,0.040275868,0.09779935,-0.051160432,-0.06982036,-0.030814646,0.05198114,0.073445976,0.011720343,-0.016790146,0.11416158,0.0030982879,0.0016082806,0.0415144,0.012722046,-0.06822878,-0.08943998,0.013771444,0.03604167,-0.0010213943,0.032187678,-0.060569443,0.04510645,0.07817985,-0.008146116,-0.005030965,-0.11610151,-0.020251732,0.053072497,0.016647346,-0.063347414,-0.048380468,-0.039441288,0.015356144,-0.035149787,-0.024305684,0.035184607,-0.07739816,-0.043686837,0.05982366,-0.05143994,0.049683023,-0.021033317,-0.07340137,0.02793499,-0.053766213,-0.004057567,0.04085884,0.038939558,-0.05852702,0.07649423,-0.12643829,0.032466795,0.02519533,-0.03029461,-0.057702933,-0.018075803,0.07252133,0.089317195,-0.017778628,-0.04365689,0.045970596,-0.08426039,0.01709588,0.0071195844,-0.06203623,0.047629558,0.0083487155,0.07518634,0.026583273,0.005154019,0.034252167,-0.00042461057,-0.07371803,0.04865609,0.010426653,-0.020414049,0.057957377,0.07194778,0.028598152,-0.032291766,-0.035405464,-0.02039299,-0.060088903,1.8211644e-33,0.06982747,-0.12855184,0.053474426,0.084472634,0.009066292,0.022134554,0.030204108,-0.029550483,-0.04957664,-0.07038044,0.09788831,-0.02207952,0.05284437,-0.04951957,0.050597508,0.12448608,-0.087749735,0.03025348,0.049250327,0.015128748,-0.04804012,-0.051127385,0.07437968,0.046442665,-0.018314129,0.068368964,-0.06636182,-0.02543578,-0.012573593,0.042791918,-0.021268828,-0.04522297,0.055817924,-0.045147307,-0.06448846,0.016747065,-0.0077050407,-0.005739747,0.03574489,-0.030586498,-0.00779762,0.030538874,-0.0067249252,0.08560182,0.06400698,-0.025014767,0.01305456,-0.025031105,-0.02765293,0.06457617,-0.0031888848,-0.04882289,-0.051477328,-0.0029504958,-0.064317234,0.0040282295,-0.00083101937,0.004041431,0.021521347,0.013492322,-0.04815705,-0.053678356,0.035328727,0.092924654,0.09240144,0.03205452,0.06425297,-0.021524405,-0.01434671,-0.053074405,0.09023959,0.036430057,0.09594791,-0.04214833,0.048607714,-0.035721604,-0.08817195,0.03548508,0.0002113962,0.012109786,-0.1450694,-0.042685784,-0.016191296,0.011360132,0.059861455,-0.043523613,0.09762119,0.12639049,-0.0065842248,-0.0004254028,-0.010520495,0.040828872,-0.037246022,0.046771195,0.0911638,-1.5760541e-08,0.08839721,-0.04529835,-0.04562229,-0.033786174,0.018989298,0.051832244,-0.039179407,-0.017038506,0.014812323,0.07864849,0.035684973,0.03543508,-0.061876602,0.025655093,0.07814619,-0.022448644,-0.050146934,-0.010961015,-0.04291234,-0.03551363,-0.0714523,0.013649173,0.0357277,0.006157226,-0.060544115,-0.011894047,0.0050708423,0.07192506,-0.012255486,0.002048067,-0.022131186,0.050349902,-0.08488283,-0.028908236,-0.045121595,0.048433427,-0.00052015274,0.0016100539,0.00622585,0.019593146,-0.0155644575,0.08188819,-0.053604074,-0.0022730695,0.016019626,-0.01076958,-0.05312584,-0.0020353636,-0.08254674,0.09119537,0.007929347,0.0053221937,0.050672036,0.008304224,-0.049717132,-0.040465914,-0.031531867,-0.07460285,-0.04002254,0.009712084,-0.012481447,-0.03353869,0.0757238,0.056482807 +1.10.3.4,"A flavoprotein which catalyses a 6-electron oxidation. The enzyme from the plant Tecoma stans requires Mn2+ and FAD [1] whereas the fungus Pycnoporus coccineus requires Mn2+ and riboflavin 5'-phosphate [2], the bacteria Streptomyces antibioticus requires Cu2+ [4] and the plant Bauhenia monandra does not require any co-factors [3].",384,0.99999994,-0.03810398,-0.0418685,-0.16701265,0.022511028,0.12389628,0.04626579,-0.0780589,0.041335896,0.02792213,-0.015764164,0.071961366,-0.05708329,-0.019003822,-0.010132952,-0.09776297,-0.002439743,-0.05140971,0.0042843902,0.039743576,-0.015723063,0.012052837,0.0055075916,0.03166016,-0.02214112,0.046624213,0.027882561,-0.03181321,-0.023807162,-0.03858176,-0.07945306,0.01411357,0.11910173,0.06292473,-0.08878903,-0.026931575,0.08976134,-0.004800137,-0.052394886,0.069226205,0.04843044,-0.05528673,0.030066978,0.05964411,-0.017557655,-0.035614703,-0.0024335496,0.058487874,0.08841792,0.02423451,0.01095984,-0.055716608,-0.0007669323,-0.1148907,0.06738042,-0.0004970283,0.039713513,0.0066162944,-0.021644572,-0.016001575,-0.020286556,0.053723898,-0.050166655,0.040998366,0.03549087,0.0033914982,-0.039147016,-0.062359557,-0.03631264,0.0454579,-0.014068117,-0.031852722,0.031292148,-0.0497279,0.01913129,-0.052142713,0.110560335,0.048052818,-0.07029429,0.028505707,0.034262784,0.009004784,0.040537424,0.018479278,0.055820744,0.090339,-0.0046655904,-0.00933011,-0.012619956,0.019387102,0.075291984,0.14929028,0.05292214,0.07618765,-0.014973537,-0.048927512,0.06275591,0.0047711194,-0.015488602,-0.08098224,-0.054768283,-0.058557358,-0.021332318,-0.03302415,-0.013983438,-0.013417751,-0.016301969,-0.0031812172,0.039175168,0.08311544,0.0113146715,0.04707898,-0.04031937,-0.030032292,-0.105840534,0.028010253,0.015400265,0.10571402,-0.07015232,-0.04281037,-0.01366077,0.024806421,0.005926414,-0.033257186,-0.026610607,-0.007046903,0.0023033707,-0.06513317,5.709298e-33,0.06938405,0.08574922,-0.029399734,-0.016273659,0.07963781,0.0021265878,-0.06397771,-0.048012726,0.02132842,-0.068788014,-0.15832698,-0.00843576,0.00039363536,-0.011952902,0.039936356,-0.0049225413,-0.015290225,-0.04171041,0.09056103,0.010003731,0.049739633,0.10115152,-0.054236338,0.017413413,0.08161151,0.0247594,0.06481057,-0.007900285,-0.0067640045,-0.00042201628,0.00037694673,-0.08573058,-0.0930041,-0.0030015423,0.054916427,-0.052395422,-0.07448158,-0.08199457,-0.008265232,0.0020897246,-0.06469924,0.04848575,-0.04183518,0.038893003,0.040892065,-0.06951897,-0.05036364,0.08910775,0.0319293,0.08817351,0.05796087,0.025773332,0.085308656,0.08115034,-0.07157347,0.010176276,0.02438465,0.04450427,0.07950943,0.08855666,-0.013900328,0.016924096,0.033318345,0.041527927,-0.0078316275,-0.01326971,-0.06993173,-0.047277164,0.025943482,0.040719133,-0.0291351,-0.06242367,0.030586185,0.03295327,0.0047180057,0.012813144,-0.015275552,-0.0681515,0.015150105,0.024025287,-0.038054056,-0.043272536,0.03220692,-0.059838623,-0.062380653,0.016175607,-0.07579473,-0.011163066,0.026501302,-0.0021997346,0.045772977,-0.0019185243,-0.019775774,0.01062553,-0.00073815655,-5.2104746e-33,0.0895302,-0.11504612,0.07430861,-0.04587781,-0.09398729,0.016471501,-0.05027294,-0.10416275,0.027627837,-0.051665124,0.04244894,-0.06855149,-0.03327294,-0.024667818,0.059470523,-0.016989728,0.021171082,0.12337344,0.010944957,-0.011817813,-0.019810557,0.063511975,-0.0018533478,-0.015047547,0.009321171,0.012874011,-0.018810142,-0.028725915,-0.01008923,0.009100584,-0.032096326,-0.04153976,-0.036870386,0.01506735,-0.0441738,0.031183926,-0.059472922,-0.018046541,0.07664115,0.0675611,0.11261093,-0.00076268875,0.040790133,0.06786073,-0.00094042876,-0.057817884,-0.11500548,0.054521516,0.092994064,0.0064440337,0.040974244,0.014877177,-0.05971429,0.017470578,0.059436817,-0.020391263,0.04679791,0.004631819,0.009943662,-0.019284727,0.015230404,-0.07479299,0.013925652,-0.027398845,0.043799702,0.095752925,0.0057673254,0.079246245,0.0893363,-0.046582915,0.03372649,0.027808117,0.027000556,0.026107693,-0.03550841,-0.0021065066,-0.028927945,0.052651778,0.007440698,0.011097543,-0.034720708,-0.010457264,0.053561345,-0.04557939,-0.044069514,-0.047045127,0.056972515,0.022682926,0.032113947,0.04017717,-0.007754806,-0.013026845,0.036267586,0.016153734,0.07991716,-4.3602938e-08,-0.00797727,-0.03999909,0.07516831,-0.0493791,0.015872113,-0.014921415,-0.01870017,-0.05742456,0.044408377,-0.006189652,0.030270293,0.103265375,-0.040908795,0.00743959,0.049089983,0.0018394645,-0.038556375,-0.025373766,-0.026278425,-0.019353114,-0.071893916,-0.0219748,-0.11075674,0.07751765,-0.028264435,-0.004235496,0.030282948,0.018379517,0.06439751,0.004281967,-0.004898546,-0.01784455,-0.030730968,-0.058388963,-0.08555686,-0.031605568,-0.020042239,-0.08147018,-0.06737638,0.02390837,-0.072987676,-0.046367865,-0.019079622,-0.0035583295,-0.08882048,-0.060086474,0.0033585783,0.011081879,-0.014541545,-0.019304907,0.05501639,-0.0218786,-0.027110906,-0.024189357,-0.071222536,0.017571978,0.02421355,-0.005820083,-0.06403505,-0.07680734,0.011061655,-0.029417912,0.14828964,-0.043766227 +1.10.3.6,"Acts also on benzene-1,4-diol and, more slowly, on some other p-quinols. Not identical with EC 1.10.3.1 (catechol oxidase), EC 1.10.3.2 (laccase), EC 1.10.3.4 (o-aminophenol oxidase) or EC 1.10.3.5 (3-hydroxyanthranilate oxidase).",384,1.0000001,-0.04035002,-0.10053575,0.02942375,-0.07134884,0.17601764,0.003549137,0.019919096,0.06028962,0.12808685,-0.031050814,0.07962956,0.0035116998,-0.09122361,0.047181364,-0.034400217,0.026441876,-0.046654064,-0.0027189758,-0.03169305,0.0128360735,-0.011698054,-0.0668,0.03256935,0.008044215,-0.043585576,-0.0020210305,0.052641567,0.079033546,0.003318923,-0.08930653,0.04423419,-0.038070682,-0.009070478,-0.0033420236,-0.073218174,0.022421516,0.01723975,-0.093435995,0.031828914,0.028304923,0.088190086,-0.053915553,-0.021932296,-0.02676461,0.06926217,-0.04351733,0.010905736,0.045232873,-0.025154242,-0.032488108,0.014590511,-0.044793364,-0.02914294,0.034886062,-0.03764745,0.057060756,-0.088136025,0.062080856,-0.003923602,0.07205779,-0.034319773,0.05291141,-0.008777953,0.033623017,-0.052925315,0.07843477,0.05810231,-0.08024134,-0.005961367,-0.015267065,-0.06411208,-0.07077981,0.024506502,-0.020105852,-0.01312462,0.020033248,-0.02446136,-0.017956287,-0.04841949,-0.074067175,-0.041909147,-0.031091917,-0.05585015,0.0070921797,0.042342085,0.007955489,0.00025261732,-0.061420873,0.037369017,0.015843742,0.06349418,0.0017719946,0.013792308,0.02457359,-0.07070975,0.0669422,0.023491388,0.082812734,0.028669778,0.0032494338,-0.04464714,0.0948743,-0.06502759,-0.093151554,-0.0818371,0.08190325,0.0565346,0.0028332397,-0.010745178,-0.010342855,-0.0813884,-0.09719905,0.009561136,-0.06972379,-0.04317678,0.02848166,0.03961755,-0.07738155,-0.008827408,-0.018499915,0.014126437,-0.030708218,0.04594773,0.012686863,-0.050527543,0.05884052,-0.032094896,2.6266961e-33,0.042821787,0.021815822,0.035424307,-0.018539086,0.049566343,0.01750475,-0.106137335,0.0612431,-0.07770764,-0.08574332,-0.07015515,-0.027425159,0.005603069,-0.049790055,-0.034197908,0.01867561,-0.013647555,-0.030896783,0.00046252404,-0.025319085,0.04706824,-0.0002612333,-0.079203166,0.011364525,0.04161936,-0.0051580905,0.009210538,0.03054422,0.036034495,-0.016108003,-0.025997626,-0.021475028,-0.05202306,0.001634807,-0.10042784,0.07467936,-0.046396412,-0.016725188,0.020397563,-0.0083438065,-0.0028898513,0.040203035,0.009384162,-0.042518914,0.053774413,-0.031918667,-0.017566452,0.11123916,0.07368169,-0.017663436,0.05926657,-0.03238986,0.03646169,-0.024873216,-0.027728181,-0.019574586,-0.019408159,0.034842737,0.07712642,0.069140285,0.06489912,0.09208591,-0.036294177,-0.026795506,0.039755948,0.084751725,-0.048867345,-0.0051788813,0.012413352,0.027996264,-0.051357843,0.060919516,0.07782423,-0.03270081,0.112036005,-0.067470305,-0.05425811,-0.029920682,0.04250046,0.08340413,-0.030330062,-0.019651707,0.05919093,-0.0007639347,-0.035203386,0.017244384,0.00723734,0.01071291,0.041728504,0.046140652,0.038898777,-0.06839085,-0.0015123094,-0.0126033,-0.0036604316,-1.7024185e-33,-0.018863058,-0.06443396,-0.001529345,0.043589167,0.014430009,0.051769197,-0.022545503,0.004884788,0.055012945,-0.0022930338,0.10469243,-0.09135493,0.005852057,-0.076939024,0.040675916,-0.008319838,-0.055714622,0.02735821,0.039587557,0.0108875595,0.013179886,0.039867297,-0.013365635,0.06722847,0.03528616,0.039387655,0.0009865614,0.002985776,0.071658574,0.018950652,-0.050245143,0.019949744,-0.03614991,0.0046129334,-0.0075140293,0.0660748,-0.08012872,0.009132903,0.01449507,0.0023241919,-0.07845635,-0.049087025,0.033532545,0.059887417,-0.024664167,0.09840065,-0.07912703,0.006107806,-0.021020934,-0.024184166,0.013988777,0.0765915,-0.0852072,0.03646455,0.12321,0.07525764,0.003538185,-0.031120546,-0.031829767,-0.015256645,-0.037057135,-0.011453073,0.008184133,-0.042141203,0.05164929,0.0292872,-0.07308988,0.11528445,0.052253734,-0.020098673,0.05430487,0.0026686464,0.012368097,-0.016413914,-0.05433295,-0.045977417,0.047499824,-0.022884179,-0.0443539,0.0020166663,0.049323652,-0.034701653,-0.06385385,-0.030881988,-0.09854515,-0.0035496983,-0.009862954,0.10225609,0.0007065319,0.056403898,0.011932528,0.061084665,0.00453224,0.084000416,0.030342871,-4.3477154e-08,-0.0019175108,-0.010654673,0.0799608,-0.011774206,-0.028016748,0.0046454477,0.03780408,0.040324327,-0.0013277337,-0.015490525,0.0024346546,0.07742861,0.0034405878,-0.013929645,0.07063052,-0.039202243,-0.048110105,0.04807048,0.004895313,0.09976275,-0.027135778,0.026183559,-0.10243762,-0.08485852,-0.0054387166,-0.063477986,0.049192924,-0.0024045915,-0.109802365,-0.04381566,0.024659915,-0.0034404858,0.021694541,-0.003886024,-0.008940734,0.034301367,-0.057078034,0.025855204,-0.08295123,-0.026895767,0.027993241,-0.12683982,-0.07361277,0.027319077,0.046910316,-0.021813331,-0.01022356,-0.046154212,0.052991137,-0.026325151,0.0296434,-0.023316164,0.02342908,-0.082283236,-0.063302964,0.061713677,0.005660011,-0.09106839,0.039948814,-0.11345712,0.052927908,-0.04319479,0.15328208,0.13191266 +1.10.99.1,"A cytochrome f,b6 complex separated from chloroplasts. Also acts, more slowly, on plastoquinol-9 and ubiquinols. Cytochrome c-552 can act instead of plastocyanin, but more slowly.",384,1.0,-0.118904315,-0.0008683983,-0.07892207,-0.0005285264,0.014638665,0.05849602,-0.04201953,0.042827424,0.010923634,-0.021430783,0.023068951,-0.054894604,-0.028558996,0.06404696,0.017626414,0.056893438,-0.11806632,0.05412075,-0.090963125,0.0148415025,-0.035316415,-0.040650073,0.026831726,0.044753198,0.018006653,-0.028180663,-0.0349739,0.09318781,-0.0036837258,-0.06739538,-0.036179304,0.045877792,0.031780142,-0.015523885,-0.010243861,0.10676375,-0.017233096,-0.06780317,0.012594622,-0.04814632,-0.0012355709,0.015920857,-0.039020624,0.04570092,0.065751806,-0.015703995,0.017189294,0.015485277,0.034150355,-0.009599152,0.019118369,-0.004423771,-0.13226418,0.08202806,0.09296158,0.06057942,-0.11896268,-0.02780196,0.03858145,0.026750345,-0.05112853,-0.025333283,0.062623546,0.0693588,0.022047102,0.040194612,0.011060723,-0.0670751,0.030033896,-0.006468478,-0.014889443,-0.05956159,-0.04514666,-0.020253872,0.009479398,0.000103013226,-0.052307542,-0.0184757,-0.040340435,-0.066003874,-0.0034838084,-0.029715097,0.0026042627,0.11673036,-0.01989099,-0.024339471,0.017812688,-0.06382513,-0.06562461,0.022666994,0.055940215,0.0380245,-0.042725075,-0.063607104,-0.061674926,0.02178314,0.083769575,-0.0015425679,0.034944113,-0.0072113527,0.046995796,0.0372516,0.009357565,-0.09585739,0.012145136,-0.0422268,-0.02827522,0.06164915,-0.052989632,-0.044545285,-0.046272345,-0.00658404,-0.038802072,-0.03711156,-0.021205392,0.035947215,0.089734815,0.027367746,-6.780638e-05,0.06349932,-0.063735016,0.03659208,-0.036148395,-0.0072405417,-0.043642376,0.008544981,-0.0960928,4.102935e-33,0.019021561,-0.02129283,0.008656136,0.035929654,-0.03975787,-0.023629313,-0.07069207,-0.00840984,-0.036055606,-0.022603601,-0.06798834,-0.003531779,-0.0010010898,0.017788785,0.043118343,-0.024434607,0.0050101387,-0.012673334,-0.02118703,-0.07775005,0.04471523,0.058882996,-0.02083233,-0.14920232,0.080947824,0.059827164,-0.0135200415,0.053953517,-0.012220911,-0.002379368,-0.025744855,-0.03140391,-0.070726424,-0.009464316,0.06646278,0.010732283,-0.093195416,-0.05825526,-0.017422372,0.039500788,-0.07485782,0.014644898,-0.12392226,-0.022995722,0.10899628,0.0274654,-0.06681442,0.10766451,-0.013279339,0.055426884,0.054081455,-0.04598726,0.055193383,-0.0063883173,-0.04842395,0.013625313,0.047793612,-0.023915758,-0.055920087,0.06472522,0.054843664,0.04926086,-0.052646708,0.067842126,0.086145565,0.03429448,-0.13803059,0.018027803,-0.07567164,-0.0032354821,0.008420579,0.006397778,0.038554724,-0.04008413,0.12863536,0.012614592,-0.0236286,-0.034815248,-0.02217039,0.0058523524,0.015498463,-0.0311667,0.03391263,-0.05106622,-0.025456803,-0.0089305155,0.012221347,-0.07436878,-0.029581893,0.024934232,0.028029319,-0.033105493,-0.0053054113,-0.06932565,0.03674102,-6.0136443e-33,0.07902299,-0.10754093,0.102410965,-0.023996392,0.007746308,0.05486591,-0.03749098,-0.08854712,-0.0014721953,0.057580493,0.040502127,-0.037167896,-0.043480307,-0.018637313,-0.044264615,0.024650717,0.03675953,0.07159529,0.015814718,0.057468537,-0.053014554,-0.011784476,0.015385902,0.028872546,0.025272368,0.027874392,0.0106148105,-0.027443511,0.08552859,-0.0025427013,-0.11165561,-0.029490206,-0.062559925,-0.042516623,0.032387797,0.018118534,-0.0037045048,-0.013424078,0.015550652,-0.016577767,-0.0023769576,-0.016906863,0.041438676,0.0066286433,0.04464263,0.025820276,-0.07399037,0.05403489,-0.077853784,0.04266266,0.011938009,-0.014087542,-0.046553995,0.04921019,0.017130792,0.054850325,0.044919603,-0.0853137,0.036414936,-0.020143487,-0.023327462,-0.12736683,-0.049008537,0.06797362,0.032215293,0.07314884,0.06286629,0.038286027,0.049075115,-0.091943584,0.112682424,-0.03186919,0.008091397,0.02331814,-0.058102243,0.016449375,0.06325773,-0.02983741,-0.005136019,0.012092626,0.066198766,-0.022069616,-0.02280194,-0.004984192,-0.036961354,-0.023695927,-0.022186618,-0.0056102555,-0.02384487,-0.03662828,0.03216224,0.09810152,0.011244195,0.06676406,0.048929792,-3.5147227e-08,0.0723466,-0.049406286,0.056337666,-0.07286564,0.07493397,-0.019332873,-0.045478705,6.977817e-05,0.0038134083,-0.027750988,0.012568379,0.09440826,0.0896576,-0.0548458,0.04189085,0.030430539,0.045308694,-0.06765289,0.018332642,0.031915627,-0.11342686,-0.03229706,-0.0627718,0.045002446,-0.00682101,-0.1017429,0.03154881,0.090969324,0.021480354,0.022091333,0.083603956,0.017875252,-0.05116171,-0.010109269,-0.023317872,-0.00073570956,0.047384262,-0.08609199,-0.076352805,0.062280755,-0.019102637,-0.066518456,-0.02880043,0.050384242,0.019954352,-0.08813565,0.06451552,0.004275432,-0.0038188833,0.024135591,0.01694643,-0.011012421,0.021050302,-0.082856715,-0.07546955,0.058067173,0.052260403,-0.03787727,-0.022156484,-0.029935146,0.044360485,-0.017641539,0.12534457,0.052265123 +1.10.99.2,"A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the oestrogens 17beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3].",384,1.0,-0.050205074,0.03713057,-0.070548594,-0.042554185,0.07145886,-0.014827512,-0.053127494,0.02545142,0.029824805,0.0034692627,-0.06404563,0.029147834,-0.088634655,-0.00038187642,-0.060019493,0.09207879,-0.016566753,0.015823852,0.019589398,0.02341423,-0.0662628,-0.050271887,0.0045414716,-0.015441538,0.036159728,0.010377625,0.0032305054,0.035841703,-0.11927964,-0.040180083,0.043718174,0.00646014,-0.012366854,-0.009494269,-0.085466646,0.076880984,-0.07414798,-0.0015462764,-0.024083147,0.051550183,0.002009313,-0.012280265,-0.051616695,-0.04312433,0.020325607,-0.088443525,-0.063287914,0.06973771,0.0079888385,0.024108358,-0.06652709,0.010218334,-0.05173655,0.086353526,0.06188998,-0.04699866,-0.06812963,0.06606933,-0.03004087,0.031927474,0.020151079,-0.04323124,-0.045635328,0.007629595,-0.025042793,-0.023412183,0.01415577,-0.05177195,0.009176283,-0.033427015,-0.03161529,-0.0073174373,-0.01527741,-0.008982395,-0.00039155927,0.07165717,-0.03993216,0.03276093,0.08254177,-0.029481573,0.04088474,-0.030342221,-0.0077725644,0.061528485,0.099169046,0.044110753,-0.060221884,-0.009327043,0.0116966935,0.032384094,0.033498585,0.01326143,0.058933474,-0.023777124,-0.055394813,0.08023279,0.026971757,-0.0131516745,-0.0808822,-0.0039417543,-0.013555097,0.04910547,-0.042100415,-0.07364791,-0.14584827,0.018357841,0.048853114,0.07564549,-0.054199822,-0.017316245,-0.04355077,-0.022217488,-0.0027425345,-0.014837629,-0.030263351,0.096232854,0.046430252,-0.08436564,-0.049637906,-0.0066694487,-0.041066304,0.008565533,0.082370564,0.024592865,0.061412275,0.018899813,-0.076420374,6.0891412e-33,0.09528246,0.06815694,-0.0072785835,0.0011998861,0.03544708,0.051900268,-0.082898274,0.055522107,-0.031520613,-0.06276435,0.00092547975,-0.050736435,0.072674565,-0.057153765,0.046784326,-0.0044584163,0.03319773,-0.0060230796,0.043926153,-0.036562197,0.09366059,0.03229452,-0.067885704,0.017524308,0.008020812,0.023369476,-0.042214777,0.07455877,0.0332915,0.021597417,-0.03206098,-0.08726156,-0.041751172,0.061383717,-0.017529672,-0.004096201,-0.14829443,-0.026588015,-0.018312505,0.048764322,-0.07448436,0.018812904,-0.04523523,-0.049107306,0.02848745,-0.033881877,0.005243046,0.05493114,-0.038697924,0.087157026,0.019687146,0.012531266,0.09162122,0.010027747,-0.065854065,0.059788972,0.0015419875,0.01633146,0.036586925,0.067475736,-0.010853197,0.06813324,-0.029507488,0.032776807,-0.045853868,-0.034408115,-0.04356268,-0.09195806,-0.011683608,0.08622933,0.006851017,0.007154749,0.13446072,-0.0034373812,0.07500409,-0.025683759,-0.013644014,-0.041452147,0.045826416,0.018313184,0.030484907,-0.065884255,0.025264367,0.020724922,-0.034466915,0.0059606917,-0.007986538,-0.038413007,0.018746538,-0.011759284,0.016241373,-0.08094849,-0.015755884,-0.08100624,0.07951127,-4.544767e-33,0.06755623,-0.017222364,0.038556583,-0.003741861,0.024295038,0.11025989,0.08181013,-0.114028454,0.06722465,-0.08180821,0.117702566,-0.033297677,0.005197931,-0.03919769,0.017557487,-0.012877378,-0.052759524,0.01248413,-0.004421579,-0.003237499,-0.022475492,0.05365364,0.009041246,0.027971584,0.013401008,-0.0075441655,0.028177958,-0.014425325,0.0704854,0.04026524,-0.08795603,0.061438955,-0.030767236,-0.026357349,0.027935166,0.04470118,-0.1066341,0.028028289,-0.03539396,0.052175507,-0.004938286,-0.04575487,-0.004797401,0.018993791,0.031064043,0.049144067,-0.1102927,0.08536098,0.078568816,-0.007306851,0.026643513,0.058670156,-0.04235895,0.08619115,0.107076466,0.022398721,0.08537722,-0.023647197,0.037130453,0.01404373,-0.07650232,-0.080905296,0.050941426,0.05357775,0.05677058,0.040698167,-0.02282165,0.14019619,0.014641733,-0.024664808,0.07089572,-0.040486533,0.074538514,0.069505304,-0.034399524,-0.04621271,0.043050088,-0.006006184,-0.052860633,-0.0044736066,0.052387938,-0.036997806,-0.018134734,-0.07974433,-0.03586556,-0.043147866,-0.028419843,-6.413232e-05,-0.055139616,0.04568477,0.007926355,0.037847545,0.025702259,0.069186166,0.027938912,-4.838017e-08,0.023789816,-0.06995004,0.029991195,-0.010724871,0.022740586,-0.027343752,0.017846463,0.03722039,0.011110157,0.002504819,0.012233491,0.1159614,0.00793807,0.017487401,0.060941268,-0.036010664,-0.0045614424,0.013132478,-0.037781753,-0.024443403,-0.010307723,-0.023267377,-0.15810482,-0.029581584,0.010292134,-0.05398134,-0.016083995,-0.0673591,0.03701699,-0.028640775,0.00277282,0.0059796367,0.095679164,-0.0066003473,-0.056762993,0.009217857,-0.039636992,0.034720648,-0.08502238,0.005420634,0.006487249,-0.017392201,-0.036150202,0.016327355,0.0058911913,-0.032997176,0.035433337,-0.018565383,0.020022018,0.029705398,0.019013938,0.0699232,0.048272286,-0.09910215,-0.05249351,0.0695733,-0.0052192444,-0.07930542,-0.013985952,-0.10566494,0.050601803,-0.071205854,0.1312358,0.049010236 +1.10.99.3,"Along with EC 1.14.13.90, zeaxanthin epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle for controlling the concentration of zeaxanthin in chloroplasts. It is activated by a low pH of the thylakoid lumen (produced by high light intensity). Zeaxanthin induces the dissipation of excitation energy in the chlorophyll of the light-harvesting protein complex of photosystem II. In higher plants the enzyme reacts with all-trans-diepoxides, such as violaxanthin, and all-trans-monoepoxides, but in the alga Mantoniella squamata, only the diepoxides are good substrates.",384,0.99999994,-0.026491875,0.024689557,-0.12462947,0.014040854,0.099194825,-0.014099169,-0.007611394,0.059967693,0.068402015,0.036495406,0.12067149,-0.046605777,0.015607128,-0.025726112,-0.012385775,0.05987811,-0.05943972,0.007870444,-0.053428866,-0.05878391,0.09756775,-0.06962487,-0.008456763,-0.072496176,-0.010924302,-0.024331208,-0.08945942,0.023950387,0.07553958,-0.045116816,-0.016592428,0.002982996,-0.0009155897,-0.010094289,0.007051027,0.12315372,-0.03485265,-0.16970582,0.008242976,0.01050084,0.021783238,0.024711164,-0.038106255,-0.0353135,-0.07131908,-0.02352167,0.024199964,0.0071557406,-0.096190885,-0.015045324,0.045817487,-0.067758545,0.017291065,0.00068356766,-0.012825967,-0.021016888,0.005631846,0.031131513,0.012633842,-0.00779573,0.034975864,0.009012599,0.0139617715,-0.043352377,-0.024043933,-0.053113338,-0.067139775,-0.0679891,-0.03442493,-0.07152809,-0.07261176,0.006122997,0.066553645,0.063708074,0.019158233,0.016235763,-0.048779193,-0.047144823,-0.024757106,0.017488502,0.06432976,-0.0068786484,0.009094072,0.07719167,0.088181384,-0.0094640395,0.0008487066,0.03936181,0.006622761,0.023297273,0.0042736395,0.00061640114,-0.045046616,0.04291572,-0.04336397,0.09558272,0.053193886,-0.09695252,-0.044840485,-0.061252456,0.020326898,0.006722628,-0.026456572,-0.041091047,-0.013594231,-0.021307081,-0.011247845,0.12626469,-0.087905064,-0.015895998,-0.02078889,-0.01821321,0.03666953,0.0062604984,-0.055814818,0.07870499,0.011318778,-0.031289667,-0.08396245,0.014916886,0.04193618,-0.008506012,0.0020503502,0.0432502,0.01866721,-0.001594073,-0.04283339,3.3338276e-33,0.03319332,0.035080086,-0.032583173,-0.037606888,0.028069096,-0.036928527,-0.027074235,-0.02721713,-0.0011652309,-0.06780409,-0.081556104,-0.05651827,0.03576603,-0.011231853,0.0057554743,-0.049389567,-0.056794506,0.0070842304,0.018693684,0.028435737,0.028501377,-0.03987145,-0.08742788,0.027975732,0.025824716,0.07477251,-0.0062391795,-0.049707234,0.018741548,-0.025931891,0.048718818,0.0036476732,-0.070704095,0.049386647,0.11242408,0.10250266,-0.0077432105,-0.036539618,-0.02733712,0.009564533,-0.029082026,0.07874854,0.01822565,0.008186443,0.060618304,0.015256515,-0.057351694,0.06512876,0.097096905,0.0060575013,0.043855,-0.016525686,0.034519225,-0.013736533,-0.045765013,0.0672132,-0.01248587,-0.035938773,0.0006955336,0.028346527,-0.049477674,-0.007923675,-0.009514963,0.041603435,0.0041592047,0.05350498,-0.09140346,-0.08950877,-0.04181509,0.08965183,-0.07487761,-0.084659554,0.045151144,-0.012123439,0.05956707,0.020194823,-0.015722446,0.054429326,-0.041264325,0.021369988,0.08570437,-0.008523974,-0.03571563,-0.115238786,-0.06162358,-0.03930729,-0.054579753,0.025332144,-0.0035522543,0.050741397,0.14487343,-0.011185611,0.0013161353,-0.0035655592,-0.07290411,-3.2506573e-33,0.056229845,-0.024189426,0.068381414,-0.025809769,0.034543034,0.07765053,-0.070339106,-0.050097704,-0.031199705,0.006498037,0.09822545,0.07716518,-0.06189472,0.06105691,-0.028670121,0.026720824,0.07489752,0.08089993,0.019456327,-0.03762452,-0.0941869,0.088105306,0.004499486,-0.022060856,0.06431395,0.017490871,-0.0008190874,0.004361033,0.035630334,-0.0025552122,-0.07020345,-0.05596596,-0.04685687,0.02424646,0.05057756,0.030553687,-0.018132575,-0.021335451,0.0050055194,0.12337012,0.017398542,-0.058599055,0.03204256,0.04330301,0.023773877,0.05965966,-0.092286535,-0.01748731,-0.040940274,-0.016445668,0.01148624,0.045513596,-0.061807346,0.046277143,0.06399844,0.057936862,0.02274695,0.025020478,-0.0657864,-0.0064316383,0.005876001,-0.03931449,-0.0053359503,0.022180483,-0.0047992403,-0.002728186,0.051906206,0.058421616,0.04544598,0.004636582,0.09933232,0.03245447,0.035024483,-0.026983904,-0.010102078,0.0006864594,-0.06633328,-0.033776168,-0.058836553,-0.062772065,-0.010523796,0.05835468,0.041488778,-0.06593371,-0.038044006,-0.05346281,-0.04294413,0.103282094,-0.025289025,-0.06679281,-0.010740758,-0.02506752,0.02349807,0.033430643,0.11311423,-4.2142606e-08,-0.09926652,-0.011936031,0.009030513,-0.07440495,-0.010891425,-0.055083472,0.038043726,0.011513996,0.05153612,-0.015872186,0.02397355,0.09737486,0.054221813,-0.03837919,0.041360855,0.02516824,0.046743724,0.002460941,0.018039184,0.062209275,-0.11489714,-0.04617218,-0.12773526,-0.017732486,0.02485282,-0.021144783,0.08539843,0.03142481,0.032566857,0.002563971,0.063838094,0.050486315,0.052026987,-0.038719706,-0.13099107,0.026891533,-0.067457765,-0.014176797,-0.04918959,0.0023984436,0.0062519005,-0.010591957,-0.01244113,0.0039920425,-0.015467891,0.0655147,0.06730317,-0.005217776,-0.009014206,0.03493898,-0.0049610483,-0.06959337,0.01871344,-0.04804512,-0.07537919,-0.039616164,0.04241492,0.0108216675,-0.002737703,-0.00041155584,0.007862702,0.039837323,0.17128742,0.041347187 +1.11.1.1,"A flavoprotein (FAD). Ferricyanide, quinones, etc., can replace H2O2.",384,1.0,-0.008966438,-0.045188807,-0.06916737,0.024144042,0.1121725,-0.028098747,-0.01469084,0.08431267,-0.025701601,-0.06104663,-0.008230442,0.04227524,-0.10318333,-0.0051722247,-0.05025723,0.06420901,0.008972436,0.019272432,-0.012314773,0.0076935007,-0.028601598,-0.0065672286,0.002497762,-0.02689184,-0.069405556,0.036165945,-0.0021596728,0.049445223,-0.05452744,-0.032898795,0.055699375,0.06603419,0.029900383,-0.020116914,-0.042194568,0.01795192,0.0049370443,-0.032822073,-0.0087847,-0.005919253,0.05677712,-0.024103792,0.005625927,0.0063521117,0.08974711,0.0035896057,0.0008748396,0.03223327,0.014907613,0.081637785,-0.046510257,-0.042554133,-0.0753746,0.006813123,0.05819529,0.073732145,-0.007823923,0.024272224,0.02469889,0.008520309,-0.026086552,-0.04711423,0.0766789,0.018370425,0.018899582,-0.05871644,-0.008790618,-0.027303662,0.047939282,0.009999516,0.005770458,0.0023529045,0.017392172,-0.0072770785,0.03692365,0.08327259,-0.04641378,-0.02679752,0.11410925,-0.015219412,0.040351838,-0.054007366,0.11292357,0.070502676,0.07352158,0.012887082,-0.014205006,-0.07314657,-0.05638744,0.059935234,-0.029363854,0.04849472,0.09512605,-0.022866309,-0.09448855,0.08281493,0.049909364,-0.017757209,-0.052024476,-0.00045682333,-0.09134952,-0.04746402,-0.016109452,-0.082540296,-0.06453923,-0.018434074,-0.014987531,0.039232213,0.041897416,-0.015695883,-0.0016485351,0.010502917,0.0078075356,-0.0882564,0.0514409,0.042974953,0.057579584,-0.015189042,-0.028042795,0.0011861018,-0.020089868,0.06032028,0.037284847,-0.030999748,0.020424822,-0.040962726,-0.06099832,2.2515007e-33,0.062475104,0.07105337,-0.01859098,0.02897385,-0.013702181,-0.021262564,-0.10154129,-0.037421748,0.11109447,-0.06963359,-0.06192886,-0.022851769,0.0011601556,-0.05625916,0.02088907,-0.032874856,0.023989083,-0.025299419,0.096874386,-0.056011483,0.011628622,0.02585933,-0.025628254,0.019492263,0.056199156,0.043814648,-0.013390689,-0.045464136,0.062863715,0.028802058,0.017398503,-0.08303098,-0.023587542,0.00029403722,-0.071100935,-0.017580733,-0.09194908,-0.050781745,-0.10178302,-0.0037763517,0.027902123,0.037372783,-0.021979026,0.018868543,0.035228685,-0.084597506,-0.017944226,0.09327203,0.024043662,0.023646867,-0.024114963,-0.05496278,0.061631322,0.06328561,-0.07627382,-0.03200265,-0.00010992501,0.018574623,0.122854985,0.0031858198,-0.0034453156,0.08195966,0.021197902,0.067268096,-0.03260565,-0.030047407,-0.06085119,-0.053180944,-0.017566204,0.09325091,0.091610394,-0.04505197,0.12547907,0.0014765016,0.011333985,-0.06897912,-0.0287294,-0.060237568,0.04057016,0.011966578,0.03515616,-0.041046888,0.06651527,0.0039222427,0.010867376,-0.006135283,-0.039376203,-0.028705865,0.009339055,0.054301154,0.052211534,-0.048235923,0.018932397,-0.08442053,0.054389197,-4.425058e-34,0.0048465994,-0.062479895,0.021195142,0.060873702,0.009698073,0.052375834,0.0016596023,-0.053233467,0.03325745,-0.06757135,0.062553845,-0.10966618,0.008489834,-0.05669812,-0.011061346,0.032132074,-0.06682958,0.047468197,0.044082653,0.007945735,-0.004506116,-0.009870724,0.040320233,0.09030227,0.08996088,0.016569339,0.032558676,-0.03536387,0.03230912,0.09507676,-0.044295672,0.028905962,-0.06252214,0.008469117,-0.0015506698,-0.0055316254,0.0042193467,-0.008633691,-0.075303234,0.033395093,-0.04415744,-0.0348113,0.06573626,0.07396383,-0.012587164,0.09008525,-0.021477444,0.04294855,0.03226375,-0.009827791,0.0023208428,0.025392981,-0.13162374,0.07416702,0.026700411,0.034840837,0.041335505,-0.011797839,-0.03511028,0.032541715,-0.017784806,-0.11838158,-0.012272678,0.022834558,0.106483296,0.11903225,0.025186207,0.1211656,-0.0058858185,0.0024099874,0.11143263,-0.012252436,0.050782364,0.03651393,0.049980838,-0.052086268,-0.0038812095,0.063257635,0.0024119378,0.0046890397,0.01651632,-0.027594043,-0.017863132,0.020006342,-0.006722672,-0.11569784,-0.03112697,0.05511949,-0.059980344,-0.013679515,-0.025013614,0.052370403,-0.03598494,-0.046333387,0.05462,-2.8866333e-08,-0.03209705,-0.11024593,0.09717166,0.018688982,0.06794903,-0.0028462196,-0.107232735,0.060438704,0.019924339,-0.014861807,-0.06974668,0.12192046,0.033394918,-0.07226184,0.015365042,-0.03999783,0.06635377,0.04584538,-0.05163757,-0.0016037921,-0.097012445,0.0361458,-0.09961072,0.0023672397,-0.053893253,-0.03781951,-0.016263613,-0.06238584,0.05912595,-0.059830878,0.020037245,-0.025223358,0.03390861,-0.038259726,-0.08044363,-0.0062892186,0.02147528,-0.052694716,-0.08326124,0.008445614,-0.058470704,0.012528224,-0.03340321,0.007306941,-0.01012702,-0.07214235,0.051550183,-0.014647406,-0.043490313,-0.09383767,0.030474309,0.0006377852,0.014280456,-0.056358706,-0.049246293,0.015604802,0.07448979,-0.023494894,0.0108220875,-0.058125004,0.00953808,0.003710078,0.10388605,0.025799308 +1.11.1.3,Acts on long-chain fatty acids from dodecanoic to octadecanoic 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+1.11.1.6,"A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase.",384,0.99999994,-0.036228582,-0.04569667,-0.09144367,0.02063084,0.060848575,0.026286153,0.020701222,0.06779181,-0.009834311,-0.05067467,0.09764315,0.0008545504,0.00032204733,0.011026003,-0.021281822,0.05374831,-0.058456015,-0.018023618,-0.036168754,0.047617815,0.066888064,0.03877941,-0.037425615,-0.08335224,0.08306824,0.0758395,0.038191356,-0.05479246,-0.005229764,-0.01400431,-0.023694925,0.0046139467,0.08030471,-0.06775857,0.14264406,0.0754873,-0.018708779,-0.06494235,-0.04367713,-0.047928512,0.053720936,0.0030589593,0.07487601,-0.06589325,-0.020355953,0.0042093424,0.112723276,-0.035053257,0.005931473,-0.0010061138,-0.030481722,-0.080569096,-0.023751197,0.04265721,0.014458032,0.0073627904,-0.01753534,-0.012989915,-0.040242,-0.025443655,-0.030408697,0.0010156258,0.030861713,-0.02232414,0.069912046,-0.037585065,0.012102655,-0.061384447,0.03604759,-0.062518895,0.021821594,-0.016950008,-0.009256036,0.051679812,-0.020715619,0.06146407,0.015953733,-0.014605472,0.07017978,0.0040577203,-0.052820414,0.016343197,0.075401016,0.04935853,0.050995316,0.07615932,-0.010648602,-0.008835645,-0.06180623,0.019246317,-0.08448157,0.010963417,-0.050525542,-0.011754831,-0.09298884,0.028720763,0.032387856,0.017350845,-0.025527306,0.001175753,0.050693907,0.07074505,-0.06459216,-0.08272591,-0.010487283,0.006581283,0.017679298,0.047412872,0.053700108,-0.034230996,0.046004903,0.019964471,0.033058114,0.008267596,0.035569325,0.04376549,0.09849878,-0.048490122,0.0316556,-0.011670984,-0.0270361,0.019334786,0.022634132,0.023978388,0.04721007,0.03609643,-0.096695244,1.7358125e-33,0.06971288,0.025400743,0.03538622,-0.0396053,-0.034518816,0.011967337,-0.06901922,-0.04140073,0.08284412,-0.069235146,-0.09270068,-0.01572317,0.043367732,-0.015907595,-0.032049213,-0.07378401,-0.018418048,-0.008907321,0.12268521,0.0012220315,0.01332584,0.045565635,-0.022544984,-0.026974313,0.017382255,0.0531562,0.062953115,-0.111936435,0.056759924,0.037931774,-0.0004926347,-0.02779648,-0.10155916,-0.060972508,0.0027032818,0.015024702,-0.011230337,-0.007914153,-0.088241614,0.059724074,-0.028127776,-0.002030309,-0.09459862,0.004079084,0.10576443,-0.142067,-0.0561306,0.07896915,-0.053496514,0.012995085,-0.0685819,-0.035747647,0.1231275,-0.0414662,-0.06988548,-0.05925006,0.051096458,0.058545213,0.027567262,0.085534744,-0.0074643204,0.069479,-0.06853432,0.04927721,0.034686536,0.0026907604,-0.045495,-0.10580334,0.00546353,0.04994318,-0.011550143,-0.060147732,0.06757616,0.011040498,-0.0011240855,-0.08023496,-0.064653836,0.040285975,0.03581637,0.008609128,0.0094289305,-0.013846177,0.021683808,-0.10311896,-0.073098764,0.02750342,0.009293462,-0.09040825,-0.040784754,-0.025325516,0.10408262,-0.020809041,-0.044882268,-0.018859586,-0.044845495,-1.3350716e-33,0.014586951,-0.09344155,-0.023341212,-0.048592214,0.010479281,-0.016331278,0.01138964,-0.023696052,0.011846321,-0.05122367,0.06757203,-0.03088213,0.07005217,-0.027637376,0.022705985,0.021752253,0.0018982055,0.06722129,0.08378777,0.025113637,-0.04971159,0.071992524,0.0399193,0.15828596,0.0560366,0.015778683,-0.047372714,0.047820374,0.016730549,-0.016804896,0.006600609,0.024863988,-0.012995049,-0.06317845,-0.0350449,0.028286029,-0.08562041,0.010362055,0.06947956,0.047131576,0.006839127,-0.02605489,0.0014797497,0.09704042,-0.0346513,0.019594485,-0.13227822,0.054528866,0.0018160085,-0.011218197,-0.027183998,0.0013783415,0.015584328,0.011375387,0.048128024,0.0056713996,-0.01994826,0.0446425,-0.011750087,0.04217827,-0.0540272,-0.0077843624,0.024986923,0.06803881,0.029897876,0.093306385,0.016990235,0.0027696353,-0.010624957,0.00017239546,0.07034314,0.05062557,-0.017237851,0.0135190105,0.030373301,-0.051933497,0.023901854,0.064430155,0.034149803,-0.048164655,-0.045693923,0.040653437,0.004877112,-0.09699535,0.055516873,-0.064581506,-0.01993563,0.11737662,-0.018568322,-0.006443063,0.01054283,-0.016013792,-0.088553965,0.01859964,0.065581806,-4.0970903e-08,0.0008311809,-0.07617875,-0.0051260535,-0.011206073,0.0024419855,-0.0062477104,0.021305814,-0.061388887,0.08079308,-0.030422628,0.026260968,0.05551693,0.00046879816,-0.10965805,0.012101862,0.037653517,0.0550158,0.016784575,-0.042783577,0.019172236,0.013440069,-0.007447271,-0.08828816,0.028081737,-0.004520239,-0.0005085523,-0.006315532,-0.0052685104,0.025297925,-0.026162436,-0.011726248,0.041611716,0.0020148293,-0.03380627,-0.09688056,0.049243566,0.11603387,-0.0077341017,-0.07226531,-0.038987774,-0.07473724,-0.07760505,-0.047039963,-0.06450036,0.012426133,0.004323537,0.023951897,0.013559749,0.021135796,-0.0823762,-0.01866303,-0.075203925,0.024227757,-0.025776584,-0.095251225,0.05727097,0.015306676,-0.03496604,-0.0144219445,-0.017497296,0.029891599,0.031416807,0.15969977,0.024284422 +1.11.1.7,"Heme proteins with histidine as proximal ligand. The iron in the resting enzyme is Fe(III). They also peroxidize non-phenolic substrates such as 3,3',5,5'-tetramethylbenzidine (TMB) and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS). Certain peroxidases (e.g. lactoperoxidase, SBP) oxidize bromide, iodide and thiocyanate.",384,1.0,0.020986378,-0.052617993,-0.13263904,0.007878326,0.11333475,-0.010147779,0.04014796,0.13742429,0.0012464547,-0.003702634,-0.05402438,0.024277445,-0.026095072,0.03707606,-0.045423947,0.021404974,-0.054482307,0.027666027,-0.021606158,-0.032201532,-0.02405695,0.056295957,0.006701179,0.0030809704,-0.053021513,-0.003030205,0.08451423,0.005127251,-0.048291773,-0.045996733,-0.01854526,-0.0781794,0.0984235,-0.019069541,0.031003514,0.032012183,-0.029416628,-0.11639483,-0.04983573,-0.024649883,0.03741921,0.016014135,-0.10653349,-0.022965243,-0.012743066,-0.066182345,0.052757017,-0.067974314,0.016681375,0.10306989,-0.020051997,-0.036719467,-0.05207494,0.049683318,-0.053775832,-0.05030958,0.0144746555,0.014814632,-0.030331174,0.012396569,-0.0071950937,-0.015394523,0.009081695,-0.024232626,0.021049656,-0.023905385,0.07153301,-0.03175216,-0.07893264,-0.09234886,-0.005878095,-0.045701362,-0.08986957,0.018347437,-0.01848367,0.04225604,0.036654536,-0.06860868,0.037019275,0.008184,-0.07058001,0.003917203,0.06578074,0.16282575,0.027906971,0.05919065,-0.08330362,-0.0010838747,-0.012683007,0.037286308,-0.030306844,0.056876563,-0.061942395,-0.038343158,-0.001315028,0.033874374,0.027590975,0.03205833,-0.016458495,-0.009988178,0.0042569106,0.032916848,-0.08407266,-0.019899737,0.010777393,0.031523272,0.015123982,0.051568165,0.036237046,-0.02061854,0.019999899,-0.0040020696,0.09224868,-0.024105372,0.013438553,0.12137422,0.043163378,-0.0179485,0.021054506,0.0026570812,0.017612698,0.052490428,0.063153535,-0.028640874,-0.010044654,-0.014610344,-0.047722623,4.551755e-33,0.04218263,0.08717297,0.03818956,0.03780181,-0.04257448,0.01794653,-0.114633076,0.01370874,0.04715098,0.005104591,-0.09627555,-0.065357625,0.05520858,-0.081674546,-0.017123621,-0.05738303,0.0015494216,-0.018246474,0.0545043,0.008095662,0.030537212,0.06329808,0.010240213,-0.02739826,0.035779104,0.058229495,0.016075926,-0.019575477,-0.0116920285,-0.004699335,-0.029182907,-0.038885936,-0.07137484,-0.059376072,0.032545876,0.016486796,-0.043365885,0.04601077,-0.09514969,0.05829076,0.03150038,0.024445616,-0.022423564,-0.027471384,0.09448229,-0.12666954,-0.05699448,0.08842363,-0.0018954762,0.06426575,-0.024880547,-0.030226158,0.086007126,-0.027741304,-0.05726183,0.018461792,-0.023007983,0.044904873,0.107708074,0.102842145,0.10849339,0.018032392,-0.033376973,0.057685237,0.062037867,0.03205351,-0.07298313,0.016805239,0.035402037,0.054680526,-0.017038792,0.031358372,0.08290575,-0.016326444,0.011614262,-0.09030488,-0.101393536,0.05348158,0.08027059,-0.02749269,0.058597866,-0.048311565,0.0030604277,-0.039706875,-0.08503308,-0.012207444,-0.017967548,-0.0020124281,-0.051752895,-0.035542704,0.07509209,-0.060876913,-0.037850074,-0.07050994,-0.028026557,-4.6569718e-33,0.06940941,-0.07070591,0.021700747,-0.09325638,0.0040296023,-0.0072429036,0.037220083,0.025019791,0.018686315,0.015291693,0.11359676,-0.03626525,-0.03835519,-0.102861516,-0.030429715,0.08444484,-0.02938822,0.013831761,0.044272773,-0.03147942,-0.061342943,0.029309087,0.014860924,0.051246524,0.040751904,-0.030718353,-0.056344453,-0.04736635,0.078314655,0.04629497,0.0326639,0.013407576,0.0068359077,-0.08367529,-0.007879716,0.005870051,-0.033906907,0.010621617,0.04591695,-0.009871138,0.000461634,-0.020716654,0.075296514,0.08364983,0.02211379,0.10807462,-0.18897167,-0.007762137,-0.012833371,-0.014137209,-0.016328344,-0.037509937,-0.050983652,-0.013156594,0.07409273,-0.009526725,0.02134986,0.027155874,-0.0534603,0.04062747,-0.021954514,0.030773155,0.07487535,0.046233162,0.007785417,0.04627994,-0.110567406,0.029503085,0.05128601,0.004417641,0.022548439,-0.035130255,-0.0023482852,-0.03515323,-0.011309738,-0.040644053,0.03953373,0.080999546,0.020514004,0.0059219077,-0.004581907,-0.013157539,-0.029448636,-0.0030821553,0.010133136,-0.048585415,-0.039798073,0.053935524,-0.01737401,-0.050043404,-0.06024963,-0.00641018,-0.015040705,0.01569942,0.012141827,-4.5680444e-08,-0.026271999,-0.12989001,-0.019224405,-0.013454218,-0.056276612,0.028465042,-0.010697006,-0.023462275,0.055637803,0.020426642,0.0056093405,0.091326885,-0.01117146,-0.08259358,0.01247645,0.03543983,-0.0013341114,0.025497826,0.019313442,-0.016262673,-0.044216644,0.049823143,-0.05374381,-0.0060532354,0.06431287,-0.0414548,-0.061659608,-0.07737147,0.060145672,-0.0055688582,0.015887333,0.02993576,0.009476633,-0.045621365,-0.01945565,0.011670939,0.028717445,0.013834152,-0.033192255,-0.014242439,-0.009733704,-0.032126296,-0.08721712,-0.060612872,0.05318507,0.017693004,0.04162576,0.106661394,-0.020398064,-0.07371265,0.0037501315,-0.0320817,0.020673532,-0.020182723,-0.030501153,0.05796333,0.056633275,-0.05357078,0.056556784,-0.06332137,0.043159604,-0.013376377,0.15824148,0.008212849 +1.11.1.8,Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.,384,0.99999994,-0.02992273,-0.0061105876,-0.041145533,-0.053545997,0.11569481,0.096016295,-0.04265872,0.011382689,0.027292239,0.039804153,0.020498533,-0.04713682,-0.021499403,-0.04263989,-0.046394803,0.08596474,-0.13173266,0.0154788485,0.0018728655,-0.068233505,0.0013413569,-0.05673341,-0.03325816,-0.042587608,0.044859957,0.021563163,-0.009589296,-0.039958846,0.017681994,-0.03135419,-0.024718197,-0.059112843,-0.021459373,-0.0909826,0.04156624,0.07258209,-0.04870909,-0.040943418,0.02854336,-0.031264663,0.019128973,-0.07866889,-0.051842585,-0.036586545,-0.032704912,-0.0028942549,0.03991787,-0.013655065,-0.008610475,-0.054844912,-0.0068097394,-0.04317315,-0.064592905,0.022713583,-0.057969894,0.026708633,-0.013574034,0.058812063,-0.03362158,0.035236638,0.013600432,-0.054861017,0.00844239,0.008131357,0.057467896,-0.0031632213,0.032274064,-0.0674835,-0.08850191,-0.10426642,0.053596966,-0.06774543,-0.023002533,-0.021575268,0.0053327056,0.07166648,-0.053158805,-0.029195001,0.017696472,0.04276657,-0.019521879,0.055150993,0.05386601,0.054752197,0.039169926,-0.011244568,-0.0553407,-0.017857756,0.052649803,0.048565924,-0.0038789832,0.00033098712,-0.017049838,-0.0054291864,0.0114880735,0.08895858,0.05774616,0.034400743,0.05667593,-0.051331293,0.0028404386,0.06218752,-0.14994504,-0.018242532,0.029579375,0.06810411,0.0053278636,0.029913822,-0.015708689,-0.030099368,-0.023322416,0.05918436,0.04799151,0.060495578,-0.07504434,0.056588087,0.053654045,-0.007099528,-0.01846688,0.031788357,0.03365905,-0.046346195,-0.019345196,0.050940573,-0.0038770859,-0.016394937,-0.04536902,3.1604102e-33,0.05201997,0.11993685,-0.022942213,-0.008222498,0.04576574,0.016588248,-0.07919058,-0.04604427,0.007862062,0.016461164,-0.09261094,-0.046068117,-0.036593907,-0.0058351005,-0.049614172,-0.071236975,0.011515492,0.022835983,0.007945422,-0.018899763,0.025290743,0.05887812,-0.035350654,-0.0039325533,0.045830216,0.113732666,0.022677954,0.001354994,-0.054749854,-7.7182616e-05,-0.04668297,-0.07481105,0.014587785,-0.030592583,0.045657918,-0.08147294,-0.017275201,-0.036835253,0.036223803,0.0898282,-0.01149796,0.0148096075,-0.079846375,-0.034015592,0.028606994,-0.046456352,0.0034323258,0.053872176,0.025632747,-4.1293406e-05,0.008839346,-0.02004597,0.014822446,-0.038111642,-0.04048075,-0.030973675,-0.020429492,-0.06575373,0.04629167,0.100292325,0.019831158,0.018093001,0.026175426,-0.032825097,0.069913305,-0.05544162,-0.05631048,-0.015704086,0.03486745,0.035475984,-0.025748534,-0.017568845,0.07326246,0.025493212,0.069681294,-0.003946657,-0.04399843,0.039750274,0.06454919,-0.091638416,0.04522355,0.0644313,0.02463249,-0.021621238,0.042742506,0.011648148,-0.07547866,-0.08781264,-0.0046751527,0.002706426,0.044305354,-0.036919117,-0.041113906,-0.0738331,-0.08695224,-3.0803947e-33,0.028983507,-0.049396873,-0.03292877,-0.1381248,0.025309572,0.013529193,-0.023655012,-0.030927224,0.10648314,0.07515125,-0.0069951895,-0.026139611,-0.016663674,-0.058418803,-0.059711263,0.015608067,0.079033524,0.04785949,-0.046454854,-0.052860916,-0.03785077,-0.00089988235,0.024466893,0.07263795,0.060767017,-0.008624956,-0.050179314,0.06926166,0.09305901,0.093555816,-0.012874134,-0.030395534,0.042428553,0.013001267,0.08238188,0.0191303,-0.050613258,0.074097864,0.058548205,-0.018039418,0.048458785,-0.07509447,0.0102827465,-0.0206752,-0.00464599,-0.018513536,-0.16484058,-0.01871351,0.0054732035,-0.10444009,0.067295514,-0.00081072043,0.04064207,-0.033829834,-0.008585134,0.025135083,0.017250406,-0.05780901,0.031451773,-0.013167905,-0.03048587,-0.043039516,0.039773535,0.062761955,0.019324962,0.06673256,-0.038972367,0.001014665,0.0064132554,0.06157622,0.06959183,0.012827707,-0.0013430561,0.023045862,-0.04162833,-0.013067942,-0.009550696,-0.009718371,0.11508338,0.01307883,-0.0042617493,0.024383387,-0.010863719,-0.110483736,-0.043216996,-0.032026283,0.043461327,0.15934354,0.009093242,-0.0069253147,-0.019324778,0.038904406,-0.053387586,0.07920125,0.11589601,-3.6760298e-08,0.04034292,-0.08551931,0.053794704,0.07466012,-0.0104504125,0.026441928,0.038036026,-0.040608637,0.06634961,-0.051638693,0.027636435,0.059170235,0.03442502,-0.0945984,0.051845215,0.065074995,0.0155774,0.053649306,-0.0048063854,0.0036654146,-0.034905326,0.06395419,-0.047859523,-0.05857363,0.030355182,-0.01978445,0.01893156,0.022336973,0.010070366,0.07069211,0.016979985,-0.041505866,-0.027431292,-0.053374182,-0.041877236,0.0035012157,-0.035095554,-0.04022422,0.018181091,-0.07584439,-0.031876825,0.026772076,0.00083560526,0.025606483,-0.008077967,0.037921436,-0.032471716,-0.00915397,0.027859997,0.027639043,0.07376013,-0.061449397,-0.0021428692,-0.06555756,-0.08372208,0.008939197,0.023094576,0.0019055969,-0.024653686,-0.08460579,-0.03949901,0.10971621,0.23333588,-0.043942768 +1.11.1.9,"A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase).",384,1.0,-0.04923246,-0.029835396,-0.050107863,0.005007456,0.085352905,-0.020812854,-0.02510102,0.06697682,0.020212011,-0.099427424,0.10294188,-0.019993614,-0.056418326,-0.0100728385,-0.014959826,0.073961854,0.0059512514,0.026833326,-0.037622318,-0.015607556,0.012391875,0.044402953,-0.043768506,0.035470016,-0.018044716,-0.0009155663,0.008829884,0.015064038,-0.024873469,-0.04776445,-0.012033837,-0.083838485,0.1100798,0.008680147,0.022590669,0.082538866,-0.013483665,-0.074851155,-0.020828404,0.0019696718,0.001009326,-0.030695496,-0.06789044,-0.025910055,-0.030866804,-0.062061213,0.07844322,0.025732525,-0.03885127,0.022290653,-0.014225595,-0.06750615,-0.10170922,0.021394921,-0.008009175,0.03394888,-0.096955195,-0.019462546,-0.061779868,0.0055610947,-0.013070223,-0.06159429,0.068239085,0.03479181,0.04212178,-0.10505274,0.04948255,-0.086564854,-0.037606332,-0.026118727,0.01360242,-0.08056748,0.03639578,0.055698566,-0.025543515,0.025307056,-0.064114794,-0.06895394,0.10387381,-0.019306624,-0.020100115,-0.104382746,-0.021325532,0.110712335,0.048262686,-0.031199723,-0.012558865,-0.022658492,-0.053484116,0.054132726,0.0030612815,-0.049910966,0.062135715,-0.007456378,0.0053920387,0.026586547,0.08520229,-0.0034920198,-0.010860429,-0.0032705788,-0.06014365,0.10685236,-0.053976137,-0.053586435,0.02085053,0.03693247,-0.051561017,5.984808e-06,-0.012821883,-0.023123115,-0.003725095,-0.087730505,0.04461986,-0.008654827,0.041715756,0.06418243,0.06222822,-0.038330693,-0.011205436,0.012360963,0.0057539796,0.017266186,0.022052215,0.029607989,-0.008640131,0.04145692,-0.055952836,4.701008e-33,0.019435706,0.0067186854,-0.018301833,-6.0643142e-05,-0.082581505,0.023599911,-0.112240225,0.061114978,0.015307138,-0.05330601,-0.08372038,-0.038617473,0.099879235,0.031131625,0.04431177,-0.061553396,0.016576277,0.07904501,0.11497369,-0.035286624,-0.014707975,-0.010185239,-0.04605339,-0.015384056,-0.00491661,0.029675605,-0.06590776,-0.052515008,0.045038953,0.0060447617,0.003777078,-0.029470928,-0.020650709,-0.010537895,0.033311788,-0.004696704,-0.0014553242,-0.041080438,-0.035121217,-0.0415785,-0.07766952,0.008742531,-0.0770243,-0.08124967,0.044660226,-0.097522736,-0.011798511,0.080089234,0.06606205,0.014103031,-0.037098978,-0.023858957,0.08268612,-0.07894452,0.028926346,-0.012148025,-0.010637013,0.06585953,0.0031160647,0.11588653,-0.047652036,0.12227362,-0.09899897,0.017060382,0.025616247,0.019453561,-0.09249926,-0.065835364,-0.056416504,0.04494001,0.029271131,0.032874588,0.022622293,0.015253569,0.0029368228,-0.053790543,-0.019084832,0.043318026,0.0058557196,0.020585174,-0.037414197,-0.00846078,0.017143538,-0.042326767,-0.027265422,0.031507,0.02537286,-0.0014963355,0.01876283,0.07458066,-0.008831189,-0.03917948,-0.06103969,-0.004085731,-0.0039770426,-5.739974e-33,0.01302746,-0.11841684,-0.0067213587,-0.04111693,0.07053362,0.12101658,-0.0020235935,0.016191754,0.07051731,-0.020665534,0.030176844,-0.04372898,0.061962266,-0.09180902,0.032931373,0.06254461,-0.103800915,0.062412087,0.009293112,0.030555801,0.036842447,0.026013693,0.026550634,0.104580946,0.021359088,0.034905877,-0.06495355,0.0023271544,-0.005737045,0.095960334,-0.07699331,-0.035824638,-0.035949748,-0.0034474775,0.027848994,0.094611935,-0.10633917,0.006204115,0.0076314844,0.008173923,0.008786502,0.01469333,0.031919908,0.05783746,0.06777575,0.025222853,-0.05937102,0.08201624,-0.053956762,-0.054356724,-0.0034125494,0.016402328,-0.008610347,0.063249916,0.029862862,0.0767929,-0.025955489,-0.016553307,0.0014050261,0.0017081728,-0.009137672,-0.088059425,-0.020739546,0.08271117,0.025708774,-0.006856208,-0.05265159,0.0037049754,-0.009462944,0.039309714,0.13548331,-0.012025407,0.0018293895,0.009411813,0.05192587,-0.06648544,-0.051380344,-0.004156452,-0.041207682,0.026296915,-0.014799232,0.08139552,0.05173383,-0.027931677,0.029466404,0.0006718145,-0.049356047,0.04243514,0.0067114546,0.025069049,-0.01446267,0.0074038194,-0.0753613,0.054871302,0.06953951,-4.0543707e-08,0.040382806,-0.055427924,0.12884183,-0.053684738,0.077818125,0.008205338,0.05638708,-0.019148879,0.03708642,0.020618059,0.04058299,0.13550368,0.00018868885,-0.0711553,0.021349968,-0.00708813,-0.0033435535,0.039072815,0.012319143,0.012753927,-0.028728116,0.0033436099,-0.024974521,-0.019380702,-0.016970273,-0.04365586,0.011737021,-0.0059935716,-0.02711457,-0.01609977,0.08324626,0.0015449474,0.0056782993,-0.07473288,-0.023302177,0.010620889,0.04654946,-0.03584619,-0.09331874,0.058039624,-0.03372494,-0.042173885,-0.0661949,-0.005885992,0.062305525,0.01940102,-0.01019975,-0.03425196,-0.029077725,-0.015541535,0.02726272,-0.058133736,-0.0199383,-0.027670097,-0.059881434,-0.019646486,0.006139775,-0.09957232,-0.038751688,-0.040628016,0.03886458,0.08088737,0.22241768,0.0349687 +1.11.1.10,"Brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds. Also oxidizes bromide and iodide. Enzymes of this type are either heme-thiolate proteins, or contain vanadate. A secreted enzyme produced by the ascomycetous fungus Caldariomyces fumago (Leptoxyphium fumago) is an example of the heme-thiolate type. It catalyses the production of hypochlorous acid by transferring one oxygen atom from H2O2 to chloride. At a separate site it catalyses the chlorination of activated aliphatic and aromatic substrates, via HClO and derived chlorine species. In the absence of halides, it shows peroxidase (e.g. phenol oxidation) and peroxygenase activities. The latter inserts oxygen from H2O2 into, for example, styrene (side chain epoxidation) and toluene (benzylic hydroxylation), however, these activities are less pronounced than its activity with halides. Has little activity with non-activated substrates such as aromatic rings, ethers or saturated alkanes. The chlorinating peroxidase produced by ascomycetous fungi (e.g. Curvularia inaequalis) is an example of a vanadium chloroperoxidase, and is related to bromide peroxidase (EC 1.11.1.18). It contains vanadate and oxidizes chloride, bromide and iodide into hypohalous acids. In the absence of halides, it peroxygenates organic sulfides and oxidizes ABTS [2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid)] but no phenols.",384,0.99999994,0.008883342,0.0026892847,-0.10732047,-0.017257564,0.12250726,0.01943008,0.0055948975,0.03660305,0.08665926,-0.024145236,0.0032682926,-0.09197738,-0.048909955,0.0050936094,-0.08101122,0.04835133,-0.0028769705,0.025400205,-0.025962714,-0.026558142,0.07189712,0.0005188649,-0.012254887,0.011685927,-0.042638347,0.01689723,0.051624693,-0.05347128,-0.06666196,-0.097589776,-0.022034679,0.026156586,0.112952255,-0.0017060098,0.0112062795,0.094527714,-0.045962825,-0.057797182,-0.038511217,0.0073426203,-0.070951864,-0.043464836,-0.07323656,-0.0066817147,-0.0903596,-0.03217745,0.07358515,-0.026864814,-0.046858612,-0.034105442,0.03632256,0.001611194,-0.03659443,0.03775047,-0.07092275,0.0448416,-0.070574835,0.04883626,-0.047686152,-0.014178187,-0.03605915,0.021609811,0.0004701052,0.011258114,-0.050368622,-0.017953506,-0.0023979873,-0.01864727,-0.038199283,-0.09369381,-0.010537152,-0.022837248,-0.033580996,-0.02460717,0.05606467,0.060175993,0.04074043,-0.04896074,0.008525983,-0.06608016,0.005235969,0.04370648,0.015158522,0.08092178,0.05602631,0.0020044143,-0.0018646833,0.00917235,0.0173272,-0.0059721614,0.0626521,0.06757338,-0.051389486,-0.0471685,-0.010863859,0.0647475,0.07173646,0.052812334,0.028354231,-0.047231954,0.0026004843,0.08570655,-0.06446588,-0.111270316,0.027041951,0.041193713,0.009814017,0.08343145,0.09411572,-0.016619379,0.008149141,0.0151774315,0.06010956,-0.032538336,0.028304715,0.045957156,0.0711666,-0.05535148,-0.035550054,0.025719518,-0.016292216,0.012996088,0.010254364,0.019055841,-0.044125557,0.013319482,-0.08789208,4.8391194e-33,0.058648165,-0.0007505735,-0.014409881,0.0034397002,-0.054459587,-0.041746978,-0.04526142,-0.03571223,-0.013795003,-0.050592665,-0.023803871,-0.019385368,-0.054042768,-0.027449563,0.06217442,-0.024486175,0.0326378,-0.0006030613,0.048642505,0.035507265,0.003183718,0.05119667,-0.053177994,0.006308644,0.053176645,0.041814405,0.027191412,-0.03640637,0.034178343,0.016515246,-0.0029733505,-0.023085687,-0.039140884,-0.026138993,-0.027087536,0.09132534,-0.07370454,0.052527297,-0.025865952,-0.012138333,-0.028385404,0.031031495,-0.045691974,-0.07790158,0.04959627,-0.11193404,-0.034570888,0.10549393,0.042849563,0.065239735,-0.020866279,-0.034700345,0.09634083,-0.04775069,-0.01692189,0.034182515,-0.023500316,-0.017427158,0.038343128,0.09904754,-0.0001459129,0.12169446,-0.10835512,0.06014981,0.015342137,-0.010375292,-0.063012734,-0.028013937,-0.03478412,0.054344185,-0.061665375,0.030995615,0.026526138,-0.027239293,0.023808211,-0.043233715,-0.08185214,-0.060497276,0.037376232,0.03806235,0.13627855,-0.050579127,0.072421305,-0.055968847,-0.10452384,-0.01704339,-0.012153121,0.021337852,-0.06631106,0.02904433,0.025947776,-0.0949313,-0.0016738451,-0.046220277,0.019327981,-5.702715e-33,0.09552362,-0.084980376,0.009652758,-0.06647588,0.014303263,0.105576396,-0.050864194,-0.019552996,-0.0692982,-0.068602785,0.05088818,0.0029521785,-0.03643373,-0.05152569,-0.025559511,-0.0335237,0.024088424,0.106623024,-0.01789584,0.01294592,-0.038882896,0.09509816,0.0018419527,0.06019358,0.049732715,-0.016484743,-0.062477868,0.08402022,0.062351722,0.04569081,-0.00823987,0.07388732,0.014637833,0.0061765,0.005851261,0.0045300433,-0.045002885,0.020626295,0.056395743,0.03772586,-0.019482242,-0.07757994,0.04218484,-0.009645606,-0.005413877,0.09246102,-0.12854706,-0.02638415,0.045807663,-0.057133306,0.014796832,0.000949014,-0.084391184,0.004440627,0.07958976,0.04438039,-0.05416978,-0.04197282,-0.00776836,-0.04212357,-0.06297023,0.010684192,-0.012202724,-0.034512956,0.01656499,0.026072964,-0.09552648,0.0047609755,0.03818632,-0.00030248682,0.09332228,0.043736584,0.049606882,-0.04645426,-0.025440576,-0.05278906,0.0062605487,-0.031166364,-0.014133765,0.013330254,0.007092528,0.017179668,0.053365402,-0.05413497,-0.025547355,-0.09967777,-0.028484246,-0.011312665,-0.09063282,0.037883956,-0.06010235,0.020982891,-0.014673757,0.13024092,0.0635213,-4.842421e-08,-0.022353688,-0.04564889,0.082873754,-0.02628093,-0.037276804,0.05679226,0.100596175,-0.0044741035,0.019707775,-0.0060604676,-0.104124755,0.055127624,0.051320475,-0.0022102387,0.06534151,0.044430204,0.05080314,-0.029482985,0.009860252,-0.050664913,-0.029880887,-0.028941067,-0.07052962,0.037327606,0.0031667692,-0.053071003,0.037253335,-0.037473753,0.076603256,0.017123466,-0.010208358,0.027103785,0.01736883,0.00654204,0.018359696,-0.014658815,-0.042808156,-0.06581466,-0.06845728,0.027223703,0.041262507,0.032359954,-0.058201186,0.022496253,0.062621176,-0.026402956,0.06660728,0.032157402,-0.017040271,-0.042569738,0.06391244,-0.0015079129,-0.02482544,-0.0070657837,-0.07517028,0.089734554,0.08808124,-0.062027246,0.040247705,-0.0799055,0.031540476,-0.010264107,0.15832187,0.023663526 +1.11.1.11,A heme protein. Oxidizes ascorbate and low molecular weight aromatic substrates. The monodehydroascorbate radical produced is either directly reduced back to ascorbate by EC 1.6.5.4 [monodehydroascorbate reductase (NADH)] or undergoes non-enzymic disproportionation to ascorbate and dehydroascorbate.,384,1.0,-0.0455698,-0.021554869,-0.06521882,0.10093235,0.035714652,0.03856433,-0.025398673,0.110406764,0.04808815,-0.0037818188,0.017442968,0.041897833,-0.07550977,0.028797066,-0.004325068,0.06842682,-0.0405611,-0.0014054319,-0.07032698,-0.097897924,0.039149035,0.07250645,-0.03280766,0.020905768,0.07977291,-0.08708304,0.026705751,-0.02548276,-0.03417171,-0.07718448,0.09320001,-0.009627547,0.025040079,0.0102988435,0.035955735,0.038842823,0.015095403,-0.10634486,0.04484738,0.03686753,0.04436231,-0.019899208,-0.10430579,-0.020510523,-0.05049636,0.040742617,0.06745327,0.020875618,0.0027034122,0.0005118338,0.021302951,-0.015088918,-0.066745274,0.0038742556,0.012694277,0.012530567,0.03060787,0.020417271,0.0041745487,0.0019149858,-0.03145874,0.028778514,-0.03975358,-0.010598963,-0.0062796175,-0.097235635,0.07968717,-0.025271164,-0.015353228,-0.07264035,-0.021826645,-0.07800483,-0.051171847,0.07220743,-0.0010047931,0.015767574,-0.067424834,-0.06747968,0.012634675,-0.020101754,0.043544322,0.018589051,0.02993693,0.114868395,0.042299334,0.04114913,-0.06355719,-0.003963472,-0.045036383,0.009700044,-0.036345284,-0.007395216,-0.001416143,-0.034117173,-0.07500841,0.020053236,0.12812568,0.023234315,-0.006241299,0.02639033,-0.02661174,0.041040927,-0.026917653,-0.03400539,-0.051614523,-0.026628224,-0.003120567,0.070410825,0.051374577,-0.030487249,0.038436532,0.019594714,0.031496234,-0.045077313,-0.026544899,0.10713563,0.05860767,-0.02362675,-0.09911995,-0.031114569,-0.010452147,0.021799315,0.051448815,0.041769512,-0.05953168,0.0018894082,-0.0549655,7.325888e-33,0.047302928,0.036736995,-0.004645046,0.0026881138,-0.06666682,-0.0072431024,-0.099924736,0.03333751,0.07659759,0.01152214,0.025341598,-0.06283058,0.05016634,-0.005394334,-0.015237856,-0.052037142,-0.045287058,0.030772155,-0.0023769035,0.0005407202,-0.028274413,0.06552546,-0.02838712,0.029580709,-0.016743964,-0.036031533,-0.025895175,-0.045261595,0.036731537,-0.0043660277,-0.059768658,-0.00078210287,-0.07821328,-0.069374844,-0.008656848,-0.06724181,-0.067879535,-0.025402851,-0.061663974,0.040283367,0.010152752,0.04382363,-0.06429788,-0.08525517,0.049163546,-0.077145614,-0.03975144,0.028843239,0.013929959,0.06231483,0.016529057,0.010895096,0.16765836,0.0066702566,-0.0032905422,-0.0024658924,0.012166101,-0.045499947,0.09908981,0.06318174,0.10324868,0.0106571885,-0.13032787,-0.01924176,-0.039708856,0.019612402,-0.04629551,-0.022729069,0.01668428,0.035567094,-0.00066414685,0.004987131,0.023900742,-0.011737826,-0.022274936,-0.043691643,-0.09641776,0.1052326,0.059469596,-0.03744291,-0.0015180234,0.020081375,-0.006257428,-0.03070774,0.010596459,0.006545028,0.059072617,-0.02539003,-0.058037765,-0.025456838,0.07944195,-0.085628115,-0.02589933,-0.10708159,0.08121932,-6.7408995e-33,0.089560844,-0.0152384825,-0.0585738,-0.064660266,0.05694409,0.0455701,0.06884816,0.053469274,-0.08109392,-0.075503536,0.0963702,0.030919185,-0.04936603,-0.002359687,0.076608345,0.0033771093,-0.016878873,0.03337396,-0.024175504,0.020308785,-0.022135917,0.045866314,0.063807674,0.032558415,0.06264484,-0.03727542,-0.07808908,0.018069651,0.09156581,0.03982699,0.013448187,0.040104322,-0.034665953,-0.03365818,-0.025875436,0.06842759,-0.064193726,0.065127395,-0.04982572,-0.032449614,-0.01966991,0.016563183,0.021560213,0.123300284,0.05449078,0.051455412,-0.17910753,-0.00554614,0.039294094,-0.005720912,0.04251401,0.05443541,-0.048947874,-0.03257789,-0.030085852,-0.035602465,0.038531285,-0.011941301,-0.007855929,-0.026443109,-0.09182839,-0.017427359,0.009458235,-0.012583321,0.016316893,-0.013404946,-0.066438906,0.03638652,0.059220847,-0.025643812,0.08631256,0.02024398,0.052098483,-0.024357567,0.040074874,-0.105591685,-0.0281646,0.06950214,0.001118214,0.015071762,-0.06527101,0.013191518,-0.02974628,-0.06159203,0.0005090093,-0.047675166,-0.043361302,0.03938748,-0.03404101,0.0076100505,-0.06262027,-0.02522644,-0.007753567,0.10548812,0.057876345,-4.1743505e-08,-0.052357506,-0.0796012,0.048927415,0.006019607,0.041854452,0.015040751,0.038193215,0.038853988,0.044111345,-0.025232922,0.027293917,0.0766631,0.028259268,0.051148545,0.021546012,0.017418955,-0.070063464,0.033946965,0.00604924,-0.034124445,0.015063745,0.039722487,-0.06861387,0.07729718,0.012237229,-0.071027726,-0.0072603547,-0.025677077,0.021322122,-0.058590975,0.09269765,0.058776505,0.0024307675,0.0022394217,-0.042000644,-0.027259877,0.006153536,0.044568818,-0.055880606,-0.0057012467,-0.047948707,-0.047842562,-0.066763245,0.025527705,0.067400865,0.012929986,0.046542622,0.040897448,-0.04157807,-0.035680268,0.0244592,-0.012468973,0.0063085817,-0.03686033,-0.10995913,-0.035251923,0.0076281307,-0.0010362761,0.016247276,-0.1004073,0.050037153,-0.019646047,0.18267879,0.009592686 +1.11.1.12,"A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).",384,0.99999994,-0.057916787,-0.03790386,-0.064634554,0.00049819215,0.09985638,0.018170608,0.011505359,0.055010054,0.041842423,-0.10182792,0.11416926,-0.022519415,-0.05363034,0.016594173,-0.015638141,0.057000685,0.0044206684,0.015528453,-0.058322683,-0.03079917,0.02263134,0.0318754,-0.03522971,0.017112356,-0.05677139,0.00865532,0.00031553677,-0.0121307615,-0.025530813,-0.064040735,-0.0042302287,-0.073381,0.10899417,0.0049293046,0.019329708,0.09526518,-0.01486657,-0.08469324,-0.025952157,-0.041516423,0.017181106,-0.034456372,-0.04523259,-0.024095988,-0.014751313,-0.06561937,0.095824584,0.030891517,0.008912156,0.009830136,-0.020063091,-0.042140316,-0.106937416,0.02898139,-0.016430888,0.04908704,-0.11375382,-0.012627009,-0.054583445,-0.0098743355,-0.0291449,-0.0674001,0.08345268,0.021291228,0.05193112,-0.116361015,0.07273595,-0.079486325,-0.029064087,-0.035096645,-0.0006883984,-0.063226335,0.021746041,0.010932178,-0.003070148,0.04402762,-0.08225336,-0.057940442,0.101539075,-0.021676691,-0.01837083,-0.08796318,0.0064590713,0.089255095,0.01958184,-0.031097677,-0.013351087,-0.036225617,-0.04888068,0.05457897,0.027033038,-0.07215274,0.049030297,-0.0056393254,0.011608567,0.029691735,0.0687086,-0.012549022,0.016746225,0.001975525,-0.0288306,0.11161953,-0.055647757,-0.040061545,0.0018295732,0.020012645,-0.033967994,-0.0064776842,0.0069975033,-0.030214492,-0.0037199557,-0.085142136,0.06585572,0.0125546735,0.03515958,0.071924254,0.059872366,-0.056112044,-0.0060638622,0.010598554,-0.01041351,0.0046286033,0.0054975776,0.02099848,-0.018023726,0.054509398,-0.09958578,3.2863263e-33,0.02545383,0.010116749,0.011879568,0.018107703,-0.07893958,-0.00093582785,-0.11630558,0.053228334,-0.01550955,-0.06665341,-0.08299438,-0.056949858,0.106055744,0.05126374,0.023388904,-0.06760092,-0.0031069012,0.055556644,0.12218425,-0.048074372,-0.0009095016,-0.016003342,-0.017635617,-0.034460485,0.023206703,0.063229434,-0.07770339,-0.010017172,0.036037844,0.020694062,0.032052368,-0.01429447,-0.0799618,8.3744744e-05,0.040344335,0.010183983,0.019416934,-0.026932603,-0.02940675,-0.056395788,-0.070494995,0.03099667,-0.08506751,-0.079643056,0.043656714,-0.09159192,-0.009805046,0.114635415,0.049330067,0.038737632,-0.02392692,-0.061099764,0.094630815,-0.09014279,0.023634793,-0.009804668,-0.023088468,0.031407878,-0.0046251435,0.098234,-0.002962034,0.07745401,-0.10730238,0.03797248,0.040620998,0.04134456,-0.0943672,-0.0396169,-0.06923852,0.05460154,0.025257923,0.0410111,0.006602199,0.016072404,-0.007511277,-0.050481442,-0.0410106,0.01258472,0.0034088397,0.05187439,-0.0152385095,-0.023787705,0.006022825,-0.050620336,-0.05563586,0.010856354,0.0284742,-0.030627312,0.021103187,0.018561471,-0.0096258875,-0.05178066,-0.048274443,0.02735766,-0.01063906,-4.4053767e-33,0.05235727,-0.09888222,0.0010304627,-0.0454584,0.07209853,0.099649064,0.025145736,0.014340951,0.0923206,-0.0075524873,0.008370804,-0.021471575,0.09547013,-0.08148924,0.02586629,0.053350426,-0.11307672,0.061119936,0.029622002,0.025604328,-0.016199917,0.008207309,0.008184058,0.10387635,0.018702205,0.031147245,-0.056752756,0.006589292,-0.016014554,0.08462815,-0.08162368,-0.032086495,-0.03933052,0.014027019,0.007512999,0.07269768,-0.08146881,0.009956858,0.031152206,-0.0133129675,0.038320474,0.040269822,0.06132969,0.056260314,0.046274792,0.0482029,-0.056116745,0.08227014,-0.07534854,-0.076604635,-0.020363646,0.014111813,0.020370945,0.07548842,0.05279171,0.10857661,-0.019078705,0.0054498385,-0.01986873,-0.004641645,-0.043600406,-0.06873006,-0.030612644,0.061730504,0.044780362,-0.021721378,-0.061166722,-0.034896266,-0.0029332507,0.03179431,0.13571353,-0.01631864,-0.015002763,0.003639143,0.032247066,-0.069364324,-0.05186295,-0.00064750994,-0.009160914,0.025313834,-0.00022238948,0.050354593,0.039944462,-0.05893082,0.02678659,0.007912463,-0.04083518,0.034736,0.0068435473,0.031722438,-0.026641836,0.0018491873,-0.05566833,0.08418608,0.07091589,-4.0801886e-08,0.021268522,-0.066117994,0.12244621,-0.046263687,0.06498516,0.039882414,0.057121072,0.0050733117,0.01829953,0.018965892,0.041965883,0.11016406,0.026635213,-0.08336757,0.01751419,0.013238903,0.014778013,0.0319506,0.011962956,0.023930497,-0.02432065,-0.019015132,0.0007996316,-0.020716643,-0.005286485,-0.066454574,0.013703213,0.0070053726,-0.03671041,-0.009864513,0.049091134,-0.02335854,0.007157598,-0.09009047,-0.059174087,0.0051502725,0.034397848,-0.061184198,-0.06025775,0.063087165,0.013978435,-0.016003087,-0.08378327,-0.051314455,0.04352703,0.033523448,-0.021427112,-0.031448893,-0.038723774,0.009470332,0.023035452,-0.051031813,-0.029058402,0.0025028894,-0.064063676,-0.0039303913,0.003174219,-0.07644819,0.009342059,-0.013273548,0.053668413,0.09534704,0.17277507,0.008292378 +1.11.1.13,"A hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ [4]. The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates [1]. It is inactive with veratryl alcohol or nonphenolic substrates.",384,1.0,0.030556872,-0.058863044,-0.035290774,0.0477349,0.14267893,0.037011992,0.04672978,0.0057612997,0.0030235602,-0.009170513,0.06974794,0.059520405,-0.008213616,-0.0070985206,-0.06987798,0.12686451,-0.07042205,0.036978897,-0.12918952,0.05152847,0.10433191,0.0434949,-0.070006385,-0.009444209,0.09103309,-0.001688757,0.04937952,-0.06703923,-0.03240872,-0.03981913,0.0021862707,0.06601446,0.10934784,-0.018551877,0.07350311,0.06420868,-0.011299155,-0.033499505,-0.029843112,-0.028088573,0.025720691,-0.025132809,0.027367506,-0.054441374,-0.031174138,0.026477827,0.06991101,-0.0782961,-0.05151148,0.048279077,-0.038950104,-0.033334114,-0.05889693,0.072691835,-0.030027347,0.031908017,-0.028484728,0.049971063,-0.029234009,0.00058737904,-0.008044484,-0.0054469225,-0.0008933184,-0.0429887,0.0016041464,-0.061941285,0.052205462,-0.06456147,-0.02787468,-0.05590714,0.01774061,-0.030744622,-0.077831864,-0.04041018,0.029974056,0.041486096,0.08578713,-0.053520575,0.047716744,-0.09636727,0.037306774,0.07062045,0.0810525,0.07816128,0.011245913,0.028705051,-0.02000959,0.01663589,-0.022640767,0.020393237,-0.032497097,0.06800143,-0.042844288,-0.00030327294,-0.034290284,0.06455429,0.06840237,0.04432069,-0.00064369256,0.04798459,-0.02114862,0.04793035,-0.021331934,-0.10095543,-0.03377916,0.0076609002,0.010626743,0.060707543,0.037634786,0.0261321,0.08559849,0.058054414,0.02837072,0.020083262,0.01111734,0.087726325,0.12794006,-0.060969014,-0.057679925,0.00024195453,0.02678261,0.044635717,0.06377865,0.020602018,-0.055849645,0.024267253,-0.0068765264,3.2342015e-33,0.029275069,-0.03943574,-0.07308713,0.031273592,-0.052011825,-0.045035146,-0.05737779,-0.018119767,0.053307466,-0.030854277,-0.031830013,-0.029372586,-0.015441013,0.05145246,-0.006482934,-0.03469966,-0.033188276,-0.017398475,0.08525178,0.022918267,0.0129577825,0.021915829,-0.12688798,-0.0097040925,-0.04226246,0.014183913,0.10578325,-0.042526174,-0.018316388,-0.01732151,0.10118066,-0.054376043,-0.101357,-0.079816714,0.013874544,0.04630868,-0.06358153,0.006503358,-0.06363115,-0.0004610177,-0.036793895,0.04391948,-0.08795341,0.013106137,0.067752756,-0.08390648,-0.042148095,0.062399138,-0.009868678,0.023042668,-0.013104197,0.00427273,0.107944235,0.014953061,-0.020946946,0.01745813,0.019598883,-0.049251318,0.02305747,0.0068317675,0.05942328,0.06433327,-0.0670982,0.099646054,0.04794327,-0.01706818,-0.0740071,-0.009998275,0.0037442467,-0.041927654,-0.008918106,-0.08695456,0.01632133,-0.006317688,-0.12429587,-0.043717746,-0.094785586,0.03733592,0.006555918,0.00058628333,-0.0054149185,-0.024666604,0.0068855607,-0.05893196,-0.09765629,0.060308862,-0.0015101087,-0.08189591,-0.0625492,-0.08459978,0.053030796,0.0017570189,-0.0357649,-0.019781623,0.0006628588,-3.8129095e-33,0.049249064,-0.07220247,0.008282946,-0.012813996,-0.04714049,0.0021713732,-0.009140849,0.015765095,-0.04757799,-0.06696863,-0.0036451132,0.0058183144,0.020917723,-0.018313227,0.06290962,0.0088299075,0.0063297455,0.05398236,0.0066527347,0.043268718,-0.026633684,0.09702492,9.368688e-06,0.08689609,-0.0016546084,0.003929462,-0.03660313,0.031971063,0.018803013,0.02283374,-0.005959879,-0.034482427,0.022635253,-0.046581276,-0.020316923,-0.02653513,-0.09030075,-0.04807932,0.0034397703,0.013598274,0.047448765,-0.040965486,-0.0011376095,0.020562597,-0.0056735324,0.028463457,-0.14126942,0.022865951,0.069627315,0.013264841,0.027007949,0.034582507,-0.07124818,-0.028508924,0.054248426,0.04343413,0.037586197,0.026534488,-0.022872118,-0.0069961865,-0.08175889,0.029096767,0.06522817,0.018392557,0.048986055,0.13434714,0.00415989,0.065204345,0.0126172975,-0.049998477,0.09551644,0.07627163,0.042720456,-0.024148723,-0.03566121,-0.06307816,-0.0029219326,0.04989936,-0.039689954,-0.052819505,0.038491793,-0.017178416,0.03405277,-0.06436121,-0.02303186,-0.11367595,-0.022743503,0.0861974,-0.0024185556,-0.06218866,-0.0039235572,-0.06697011,-0.06884022,0.011188975,-0.0024812159,-4.327322e-08,-0.060285244,-0.012174831,0.03985244,-0.05176904,-0.07705856,-0.027037635,0.11216174,0.0106964605,0.049277253,0.0009681513,-0.022365289,0.033926208,-0.060660426,-0.018567072,0.08119643,-0.008016356,-0.010564534,0.036668632,-0.053168997,-0.04152803,-0.02450972,-0.025584314,-0.055266548,0.08442655,0.0046664327,-0.029211834,0.010464234,-0.010019103,0.11195763,-0.04213033,0.028350081,0.09814858,0.045025636,-0.039051034,-0.0646727,0.07244427,-0.0036647907,-0.04738057,-0.069879785,0.035658058,-0.10115254,-0.04583217,-0.028535873,-0.048172943,-0.0018551439,-0.0664054,0.04322133,0.025323993,-0.01790172,0.021632105,0.017427033,-0.032189026,-0.020433092,-0.012099479,-0.08957898,0.028754804,0.03780148,-0.00012379487,0.032301906,-0.035801474,0.040735897,-0.0048086867,0.10497222,-0.03188528 +1.11.1.14,"A hemoprotein, involved in the oxidative breakdown of lignin by white-rot basidiomycete fungi. The reaction involves an initial oxidation of the heme iron by hydrogen peroxide, forming compound I (FeIV=O radical cation) at the active site. A single one-electron reduction of compound I by an electron derived from a substrate molecule yields compound II (FeIV=O non-radical cation), followed by a second one-electron transfer that returns the enzyme to the ferric oxidation state. The electron transfer events convert the substrate molecule into a transient cation radical intermediate that fragments spontaneously. The enzyme can act on a wide range of aromatic compounds, including methoxybenzenes and nonphenolic beta-O-4 linked arylglycerol beta-aryl ethers, but cannot act directly on the lignin molecule, which is too large to fit into the active site. However larger lignin molecules can be degraded in the presence of veratryl alcohol. It has been suggested that the free radical that is formed when the enzyme acts on veratryl alcohol can diffuse into the lignified cell wall, where it oxidizes lignin and other organic substrates. In the presence of high concentration of hydrogen peroxide and lack of substrate, the enzyme forms a catalytically inactive form (compound III). This form can be rescued by interaction with two molecules of the free radical products. In the case of veratryl alcohol, such an interaction yields two molecules of veratryl aldehyde.",384,0.99999994,0.0421566,-0.08383207,-0.07723504,0.081617884,0.1713374,0.016603101,-0.01305393,0.0062784767,0.059834518,-0.034526784,0.034854516,0.05749918,-0.09617281,0.030367963,-0.050029904,0.074833125,-0.09589365,0.026696624,-0.086070865,0.08456024,0.041136134,-0.004051477,-0.049350854,0.025262805,0.022026103,-0.064334005,0.05482851,0.0064416197,-0.06831263,-0.08752926,0.12243496,0.052291486,0.008285314,-0.011115723,0.00962409,0.033309832,-0.039039727,-0.021888794,-0.013249204,-0.020285686,0.0010852838,-0.11264074,-0.058030456,-0.06717911,-0.0140801845,0.017901588,0.08674519,-0.03971109,-0.021218808,0.004668664,-0.030151693,-0.006584067,-0.0557442,0.054026462,-0.0216452,0.01826146,0.018778626,0.048341665,-0.016769491,0.060576737,-0.037180543,0.024632711,-0.04522947,-0.0040442618,-0.0847023,-0.021149715,0.09761303,-0.07279053,-0.0031883079,-0.057725243,-0.002662592,-0.024488913,-0.052402485,-0.05686799,0.059285216,0.012384228,0.03458362,-0.05145383,0.063538946,-0.07168576,0.022439387,0.07497678,0.029859688,0.04224476,0.0066386233,0.0020525923,-0.013550618,0.023855789,-0.00022437083,0.055668462,-0.010515947,0.053765412,-0.0131115345,-0.0016531865,0.039542124,0.064409666,0.15685226,0.06842906,0.016643925,-0.0008567514,-0.024191516,0.06369307,-0.010926292,-0.1103842,-0.07730406,0.010777434,0.03295858,0.06537687,0.05297174,-0.00085835997,0.07354722,0.08066411,0.072034724,-0.03459048,0.01611459,0.08468539,0.0718316,-0.100351274,-0.034896776,0.014019058,0.008108817,0.044146586,0.067254424,0.059152972,-0.04787382,0.060464125,-0.026700329,3.123925e-33,0.018195279,0.04677453,-0.12037822,0.0070327553,-0.025967596,-0.091043666,-0.081265256,-0.009199281,-0.012019177,0.012312779,-0.024222348,-0.020473696,-0.0008648058,-0.024157146,-0.014182272,-0.0019804386,0.007430736,-0.021552097,0.019851204,0.022288546,0.036036182,-0.018095316,-0.097465284,-0.0051598907,-0.004021012,0.049522854,0.047988307,0.013677048,-0.034478605,-0.022191843,0.05377108,-0.051371764,-0.07103199,-0.016527206,0.03700846,0.016494175,-0.046410028,0.014837636,-0.01784568,-0.043164603,0.0043331804,0.075176775,-0.028037839,-0.031401753,0.098557614,-0.067210354,-0.09959554,0.09752019,0.009969414,0.064561576,0.03682094,-0.01973686,0.097924106,0.02494787,-0.02676051,0.02103776,-0.025618088,-0.06200974,0.03450989,0.011005333,0.060238652,0.06390302,-0.07379941,0.07760771,-0.01927466,-0.021487849,-0.041957542,0.05092175,-0.0068019675,-0.034836184,-0.032390017,0.032191556,0.030494472,-0.04994158,-0.013872817,0.00011687866,-0.05737572,0.020644454,0.05371365,-0.016892383,-0.014442363,-0.004617611,0.026415735,-0.056203857,-0.036576428,0.028635163,-0.023738021,-0.005287032,-0.104750015,-0.07740131,0.041400734,-0.0699212,0.020544993,-0.055097908,0.027641304,-3.5119584e-33,0.063640006,-0.07336131,-0.00011263058,-0.04204741,-0.020539062,0.060713347,0.054387115,0.014213108,-0.057875026,-0.07060782,0.007786172,-0.006722044,-0.014180394,-0.04580276,0.041673295,-0.027808618,-0.023801835,0.030693706,0.007502314,0.04507899,-0.041182272,0.0996265,-0.02122855,0.017665789,0.028663618,-0.036866605,0.017465496,0.031133113,0.051419813,0.038609903,0.04470604,-0.004227387,0.02017164,0.0034275157,0.015762383,-0.016374672,-0.08320934,-0.029315097,-0.0067886948,-0.0041610165,0.072708026,-0.05443525,-0.043748565,0.0016680466,0.027363067,0.051347647,-0.16818397,-0.009186137,0.05375249,-0.0058573326,0.011493955,0.030972248,-0.07232728,-0.026182929,0.030709855,0.024480613,0.07335975,-0.022058869,-0.028040797,-0.037230503,-0.10802903,0.003922681,0.064135835,-0.00044650337,0.055977255,0.076681085,-0.023514193,0.10395042,0.02837134,-0.08441667,0.08912388,0.06724214,0.03466007,-0.013208838,-0.035291735,-0.046619266,0.012711956,0.026833573,-0.03155321,-0.01403082,0.032961834,-0.031347983,0.03388047,-0.109997824,-0.0039778007,-0.10794865,-0.024664542,0.053222314,-0.029928146,-0.07294928,-0.0040925206,0.025764884,0.015075131,-0.0150135225,0.029434301,-4.54861e-08,-0.04972633,0.06592287,0.032481156,0.006906618,-0.005109234,-0.03423174,0.081788294,-0.007683784,-0.056353107,-0.022986177,-0.036937483,0.10227478,-0.0026047046,0.03852438,0.0537379,-0.029446973,-0.041702244,-0.007759921,-0.031927384,-0.0136665655,-0.04397836,0.01602532,-0.08771879,0.06999043,-0.02362093,-0.08947065,0.0018960182,-0.026248896,0.1357709,-0.03822418,0.0041718436,0.079763606,0.007187474,-0.00044588986,-0.07547244,0.010420955,-0.036293484,-0.034349013,-0.023372551,0.06137418,-0.016171068,-0.094178766,-0.029304074,-0.04346959,-0.015800742,-0.020048907,0.020363193,-0.04151899,0.032181267,0.055063143,0.092588395,0.021359447,0.0071810824,-0.008406349,-0.08687128,0.06611946,0.02424022,0.024021832,0.08189137,-0.08972072,0.076309696,-0.055464897,0.072812445,0.014652376 +1.11.1.15,"Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see mechanism). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants (R'-SH) (e.g. thioredoxin, AhpF, tryparedoxin or AhpD), completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond [1]. To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor [3]. The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule [4].",384,1.0,-0.087861255,-0.05970503,-0.05136927,-0.009365521,0.06723475,0.044690244,-0.043068856,0.059400953,0.07537346,-0.017732162,0.026430687,0.059294034,0.05126219,-0.030846834,-0.044391684,0.09784547,-0.064551555,0.05656085,-0.0070097777,0.061837602,0.027746692,-0.08101129,-0.031441994,0.0016929773,-0.02000257,0.047236644,0.043841925,0.06472879,-0.05576493,0.006447532,-0.032674573,-0.007781148,-0.0028125688,-0.02896526,-0.022919884,0.08608857,-0.050054457,-0.04192614,-0.06228936,-0.06721189,-0.009782556,-0.018062241,-0.046388287,0.025473226,0.0051296293,-0.025542466,0.05249604,0.0034693258,0.015755482,-0.05322348,0.025292536,-0.06688191,-0.014089879,0.042883676,-0.00796192,0.0664047,-0.120142035,0.062454667,-0.019996798,-0.041819673,-0.03814468,-0.050918043,-0.032016538,-0.015225982,0.022382593,-0.0042827316,0.04215728,-0.03986673,-0.04009917,-0.07881807,-0.037968166,0.023846794,0.06302763,0.014133104,0.036118846,0.10888609,-0.041781694,-0.024578843,-0.048717536,-0.05788729,0.0186977,0.024474123,0.04892591,0.17096083,0.07940596,-0.06656506,0.011883017,-0.027411286,-0.009887302,0.050100923,-0.036228802,0.04454042,-0.034199458,0.011519665,-0.018539818,0.042808194,-0.0054849144,0.064541675,0.039488308,-0.042472016,-0.0033213496,0.07508255,-0.013711816,-0.10690472,0.031826936,-0.011506704,-0.078179926,0.057937935,0.010044125,-0.036507055,0.008672348,0.015379803,0.011264044,-0.01421963,0.017845724,0.08704012,0.022532823,0.004277777,0.037318338,-0.04675307,-0.010581242,0.031604763,-0.02806742,0.027884062,-0.011302277,0.0024990982,-0.06542664,5.2890707e-33,-0.0020007896,0.056378506,0.02140242,0.061364274,0.0010607357,0.003661784,-0.072561,-0.0064934967,0.020877652,0.073781885,-0.082907766,-0.03894971,0.06999621,-0.016435493,-0.023792261,-0.053938832,-0.018685065,-0.072325334,0.038559623,-0.014867275,0.0088892095,0.05770506,-0.02419268,-0.038235318,0.02370447,0.057771806,0.046493948,-0.025571866,-0.042320576,-0.010013365,-0.0152392145,-0.025513737,-0.028767753,-0.06691242,0.007696108,-0.0081986515,0.015707156,0.020675106,-0.004918368,0.009908329,-0.054589648,-0.015225025,-0.0165058,-0.080235675,0.114089355,-0.14435503,-0.074113525,0.10343026,0.0022611998,0.027565531,0.07733438,-0.062022287,0.08727431,0.009647829,-0.1020861,-0.03462183,0.021390561,0.024222294,0.016257225,0.090755984,0.02060321,0.0366713,-0.073990345,0.008116042,0.023861174,0.06527703,-0.10688992,-0.058284152,-0.065392904,0.0754076,-0.01592963,0.051178005,0.032030333,-0.05070077,0.030313078,-0.0021914085,-0.031911053,0.15415142,0.11890326,0.06679996,-0.061143804,-0.0055286065,-0.06290825,0.035821736,-0.07054372,-0.004525568,-0.009095111,-0.016497226,-0.023642281,0.050137363,0.09178637,-0.08158994,-0.04177607,0.0040697707,-0.0324473,-6.379772e-33,-0.0034604524,-0.033549428,0.0048999614,-0.10386395,0.056279115,0.06725137,-0.0038026709,0.031365655,0.046330232,-0.050563097,0.056178786,0.007050819,-0.03836739,-0.0112794405,-0.032153677,0.028201563,-0.06786471,0.0662332,-0.06710048,-0.0023362837,0.02151476,0.10026149,0.05759044,0.12141695,0.048998833,-0.026125247,0.04024437,0.06422788,0.0483339,0.12804362,-0.032874346,-0.010408316,-0.0166998,0.010286884,0.01897261,0.027992174,-0.12421944,0.024111409,0.071368046,0.014720004,0.014206578,-0.043690577,-0.060740072,0.09114132,0.061371706,0.107076764,-0.079515494,-0.0026027446,0.012066644,-0.041661143,-0.0022553096,0.0059071514,0.025064219,0.012607554,0.04477759,-0.009027665,-0.050035868,-0.037531737,0.06940354,-0.016321484,-0.064381756,-0.032886438,0.028350443,0.048901644,-0.030933134,-0.00333089,-0.06561936,0.0003201818,0.046117116,-0.021576393,0.029500993,0.02780085,-0.05578197,-0.053704683,-0.016382212,-0.027135817,-0.03219476,0.053428218,0.025877418,0.04060613,-0.004372511,-0.0013232586,-0.014387121,-0.041885976,0.0202143,0.018669426,0.043671582,0.058468357,0.050644256,-0.07180493,0.009951271,0.08354705,-0.036516957,0.040804062,0.04823535,-5.0499914e-08,0.016592633,-0.06835843,0.051451698,-0.01602043,-0.025476463,0.011781231,-0.013955572,0.08435126,-0.015205776,-0.046094205,0.05094316,0.12247562,-0.028516218,-0.087973975,-0.037551396,0.003805245,0.016983317,0.008926672,-0.010030751,-0.042779554,-0.06517015,-0.051933274,-0.049329817,0.036040522,0.011276808,-0.08718195,0.020388626,-0.10240792,-0.021884594,-0.030446785,0.082818285,-0.03354793,-0.07904874,-0.002310575,-0.0804792,0.0737946,0.0143334335,0.026843928,0.044723608,-0.08098964,-0.07566371,-0.07267145,-0.072500825,0.0034140302,-0.0016612073,0.0035075066,0.03714679,0.0030311604,0.027838305,-0.0269245,0.0054543666,-0.030467229,-0.04668667,-0.07945083,-0.10805134,0.04320163,0.029803572,-0.0191441,0.023395501,-0.085475884,-0.037418492,0.058973778,0.080307916,0.010207846 +1.11.1.24,"Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [4]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Thioredoxin-dependent peroxiredoxins are the most common. They have been reported from archaea, bacteria, fungi, plants, and animals.",384,1.0,-0.08790327,-0.046699625,-0.064195156,-0.0029443235,0.061936058,0.040776584,-0.04180251,0.063337415,0.080121726,-0.016166085,0.021809202,0.06142925,0.043730084,-0.023670202,-0.047274183,0.09897552,-0.07466023,0.051394798,0.008478328,0.068641335,0.021616144,-0.083007395,-0.028039532,-0.0035650681,-0.028309612,0.05280031,0.05118931,0.055168908,-0.05328284,0.010447597,-0.009202924,0.00532032,-0.0035955275,-0.04107136,-0.016154815,0.08112587,-0.049721655,-0.06253315,-0.0680813,-0.068968594,-0.0011428917,-0.0057046525,-0.045359623,0.02937436,-0.00031340466,-0.023041736,0.055640962,0.004172857,0.022566868,-0.055291247,0.025247512,-0.060723722,-0.012693244,0.03262638,-0.008537228,0.06339185,-0.13198769,0.053392004,-0.024151608,-0.03635341,-0.044057887,-0.05208831,-0.028644603,-0.01243577,0.013227203,0.0040153493,0.048434198,-0.046168957,-0.047063477,-0.081344634,-0.040130492,0.02436833,0.054559033,0.01204527,0.038001996,0.10649717,-0.03193011,-0.04097803,-0.048690528,-0.056122188,0.0154550625,0.03117011,0.050877124,0.16881979,0.07987075,-0.058757268,0.022087466,-0.03994906,-0.0007763003,0.048342887,-0.029090788,0.03588122,-0.03960814,0.014748337,-0.017343223,0.041740306,-0.010011047,0.067942254,0.02670956,-0.03466583,-0.0070337756,0.074482284,-0.0069392566,-0.107096046,0.026342532,-0.00612829,-0.07080665,0.05941179,0.008167535,-0.037339773,0.0015326738,0.011948416,0.015413545,-0.016854553,0.020700088,0.07981453,0.018843725,0.0055615967,0.03758272,-0.05060962,-0.017037421,0.029345691,-0.04017985,0.02110207,-0.0063225203,0.014225549,-0.06849193,6.750604e-33,-0.0016768624,0.046124034,0.033850834,0.052796636,-0.00011526376,0.009848077,-0.07862428,-0.017043585,0.023276094,0.07988375,-0.08498229,-0.034785576,0.07049169,-0.02003615,-0.034457676,-0.055221092,-0.015124996,-0.062348563,0.04005729,-0.012033587,0.005521875,0.051666986,-0.024323486,-0.03892468,0.02551809,0.0763432,0.039829966,-0.026237845,-0.038257707,-0.014090547,-0.005851214,-0.023052787,-0.03845965,-0.0631016,0.0075984136,-0.011730186,0.012209484,0.014909329,-0.0106086265,0.014528505,-0.049584158,-0.0122330235,-0.017145697,-0.07176518,0.11447905,-0.147317,-0.08054788,0.114064865,0.014301901,0.040437803,0.072258994,-0.05418029,0.090155035,0.018142708,-0.10159464,-0.035783857,0.02096503,0.012466276,0.013570961,0.07651209,0.018396687,0.0373026,-0.07632435,-0.005368156,0.031360306,0.073538266,-0.109690614,-0.063284524,-0.055846944,0.06355773,-0.018265156,0.059360776,0.027695011,-0.050239805,0.02718884,-0.0056500304,-0.02533414,0.1484034,0.12018382,0.07018952,-0.06423962,-0.006807733,-0.05750557,0.03290835,-0.073686995,-0.0066486597,-0.014878156,-0.013693703,-0.030006912,0.047589634,0.09565915,-0.07862173,-0.045307133,-0.0019824037,-0.035227187,-7.697086e-33,-0.0064750398,-0.03677858,0.0039927815,-0.10210453,0.05546311,0.06287568,-0.0013288984,0.030642966,0.04813907,-0.05705231,0.05925858,0.011842671,-0.029824473,-0.014542552,-0.022168666,0.035513204,-0.061328363,0.06963847,-0.05656522,-0.0027408465,0.024256729,0.11000405,0.055373285,0.12345369,0.052182138,-0.037931938,0.04855101,0.055430237,0.054050054,0.11856263,-0.033756714,-0.005317118,-0.019591784,0.009728889,0.022515018,0.023160405,-0.12625527,0.027891472,0.06547231,0.0044485778,0.01706202,-0.04361401,-0.0632908,0.09014156,0.061478134,0.10971287,-0.08402511,-0.010232776,0.004238117,-0.02895087,-0.0060807504,0.01894685,0.028397279,0.011224958,0.04342033,-0.018812938,-0.06026653,-0.039017137,0.07565868,-0.015648646,-0.054931898,-0.034111306,0.020620136,0.04801282,-0.026059171,-0.0012734886,-0.056549925,-0.005573504,0.049632493,-0.03168193,0.030207887,0.028456125,-0.05061191,-0.03881072,-0.02435056,-0.027762093,-0.036149308,0.044096183,0.033849843,0.036915634,-0.010056215,-0.0026833387,-0.013132433,-0.04322834,0.019195428,0.026765738,0.035990022,0.05347196,0.05400173,-0.06761412,0.012040453,0.07855779,-0.03331148,0.039898537,0.04723671,-5.2839678e-08,0.01785411,-0.06032613,0.049519006,-0.02060205,-0.014761803,0.014806913,-0.011690756,0.07519488,-0.023470078,-0.04139123,0.05368431,0.12810053,-0.03026615,-0.08569441,-0.026974805,0.0070557916,0.015246339,0.004138667,-0.012923673,-0.04050719,-0.06555508,-0.0549269,-0.051872432,0.03671159,0.013014078,-0.08878095,0.023549257,-0.09150294,-0.020571621,-0.03219219,0.081238925,-0.027172077,-0.08243301,-0.004582784,-0.08299882,0.080585144,0.028285187,0.037132856,0.040724255,-0.07590302,-0.088556044,-0.079321824,-0.06747376,-0.0017042465,-0.004918173,0.017466875,0.034858104,-0.0037820896,0.02192192,-0.0247494,0.013163384,-0.026729837,-0.04717606,-0.08187887,-0.120462194,0.046137776,0.028382706,-0.010511008,0.01639658,-0.08325401,-0.041626997,0.054681864,0.06735386,0.008904132 +1.12.1.2,An iron-sulfur flavoprotein (FMN or FAD). Some forms of this enzyme contain nickel.,384,1.0,-0.08160431,-0.04635423,-0.11080732,0.022277245,0.10421197,0.008389916,0.021000575,0.049136393,0.00651284,-0.0685884,0.021964716,0.013147033,-0.061413154,-0.0024896814,-0.06664261,-0.029603163,-0.0548952,-0.024409967,-0.022976704,-0.020450247,-0.038857475,0.015735518,0.012651279,-0.07128139,-0.07122078,0.034709815,0.030470155,-0.048917014,-0.027941337,-0.008160596,0.06913653,0.022410534,0.03130938,0.0010722198,-0.027840463,0.020083345,0.022340761,0.0050189435,-0.085826546,-0.016916422,0.027812734,-0.009771081,0.037096366,-0.08023107,0.062153302,-0.00583801,-0.01652188,0.019721499,0.009536843,0.054171707,-0.012308315,-0.051232055,-0.049248345,0.07667222,0.050490398,0.01731278,-0.025521912,-0.116611846,-0.050742295,0.06739126,-0.00022104857,-0.020478616,0.014973325,-0.048008747,0.11632872,0.0048145433,-0.021257397,-0.065789446,0.030918,-0.047020942,0.040646642,-0.044741433,-0.11402508,-0.0029774534,0.0014162092,0.07700167,-0.0036301957,-0.05210814,0.08024389,-0.007336158,0.0015197013,0.07784614,0.106643766,0.06972001,0.032576427,-0.031471983,0.0042848787,0.010192404,-0.053071626,0.07899156,-0.02661533,0.051624343,-0.043199737,-0.0024279526,-0.05354195,0.093788624,-0.018624622,0.07755335,-0.09178734,0.026156768,0.008841024,0.010284891,-0.020048136,-0.045107897,-0.08939943,-0.026194947,0.009662191,0.117908865,0.013167912,-0.0045486325,0.013785808,-0.010975104,-0.0020364637,-0.09189681,0.008812027,-0.016017977,0.012849186,-0.014889788,-0.0006434431,0.045039907,0.00028371665,0.11122219,0.005465136,0.11721915,0.04995097,0.03659786,-0.12743662,-9.031923e-34,0.032530468,0.06692145,0.016469646,-0.06596531,-0.06381388,-0.010036937,-0.06684256,0.033633992,0.03902576,-0.020653041,-0.055439014,-0.0066734077,0.0017768184,-0.10051411,-0.034813523,-0.044173006,-0.02748396,-0.03325212,0.083769746,-0.061730333,0.058753956,0.033471704,0.0075909733,0.030486736,0.045064848,0.0003209811,-0.07735146,0.027259354,0.012686304,-0.001699608,0.020746669,-0.076529235,0.00020485143,-0.025751399,0.0396875,0.03239695,0.0067536584,-0.023587424,-0.10731463,0.05408204,0.02520941,-0.032103196,-0.013447434,0.04030755,0.043022957,-0.043823738,-0.109140866,0.10412745,-0.017458469,0.017394967,0.024393957,-0.0012082946,0.060234807,0.049887877,-0.09133971,0.040916797,0.007381548,0.023217643,0.036624074,-0.008735739,0.00011782557,0.05408538,-0.0066223857,0.08564917,-0.016251191,-0.020861456,-0.003272006,-0.013425818,0.02092225,0.1033494,-0.0020205665,0.03909663,0.11262934,0.02819844,0.04613636,-0.0836009,-0.031037508,-0.07831356,0.0320766,0.037478946,-0.02485483,-0.044961274,-0.040851656,-0.012380888,-0.07271271,-0.011461604,-0.06681325,-0.026407868,0.01450271,-0.08684627,0.035034686,-0.023153502,-0.054428812,-0.029666541,0.0050937114,1.8716738e-34,-0.032140918,-0.06389657,-0.024364587,0.034393985,0.0036710787,0.030910295,0.015235695,-0.0309443,0.046258014,0.030029181,0.09578668,-0.107957214,-0.004857055,-0.03291392,-0.0018546518,0.066575386,-0.05355099,0.0538755,0.0762625,0.043195464,-0.112375155,0.04448582,0.019115292,0.11025729,0.03672087,0.013438928,0.010512127,-0.008618407,0.076952554,0.06689303,-0.011902488,0.02423728,-0.031565096,-0.080026515,-0.028157217,-0.0047054063,0.013357008,-0.026687128,0.0025783253,-0.00035081897,-0.027047774,0.00872865,0.064143114,0.11984865,0.0029805838,0.06515007,-0.06512105,0.069350354,0.03708637,0.0026303646,0.0336522,0.016054468,-0.04308347,0.045857757,0.009176923,0.026305346,0.05928028,0.08705787,-0.031088922,0.050618883,-0.013135379,-0.11539981,0.04889247,-0.019559443,0.04270148,0.02387808,0.010267819,0.10632247,0.0044806106,-0.0017618991,0.086635865,0.024603013,0.076862775,0.011760287,-0.0067457478,-0.04251464,0.043830976,0.11730467,0.0050260276,0.027315991,0.028775904,0.0022597997,-0.011792277,0.0050554816,-0.018816404,-0.082798235,0.020052297,0.10126643,-0.019034507,0.004064259,-0.029405354,0.046447348,-0.049033247,-0.04572305,-0.06737301,-2.1879366e-08,0.02470511,-0.10672231,0.02295405,-0.03236418,0.071801126,0.036902305,0.04805687,-0.05975553,-0.046161618,0.0054318313,-0.016273687,0.112162694,-0.09772265,-0.07592777,0.040167376,-0.037177715,0.033234928,0.064413175,-0.026099255,-0.009305464,-0.06605351,0.081484556,-0.06528605,-0.028370654,-0.050548542,-0.025855582,0.026937759,-0.021380765,0.02876308,-0.017323844,-0.022242224,0.016937198,-0.00780194,-0.040189616,-0.13847736,0.05506966,0.056996543,-0.020487092,-0.049566016,0.016517118,-0.12180663,0.0018136766,-0.027577862,-0.05737719,-0.037627842,-0.0695575,-0.0026000426,0.013222966,-0.02265528,-0.01961217,-0.012791645,-0.026363505,-0.0096095465,-0.04184275,-0.053698145,0.066190585,0.05822659,-0.10035062,-0.015064707,-0.027166102,0.002661637,-0.010020841,0.09518916,0.066547245 +1.12.1.3,"The protein from the bacterium Desulfovibrio fructosovorans is an iron-sulfur protein that exclusively functions as a hydrogen dehydrogenase [1], while the enzyme from the archaeon Pyrococcus furiosus is a nickel, iron, iron-sulfur protein, that is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.5, hydrogen dehydrogenase [NAD(P)+]. ",384,0.99999994,-0.093828745,-0.019948252,-0.13516697,-0.026378205,0.077268444,0.015618083,-0.0837647,0.077569366,0.048001733,-0.0769568,-0.02234544,0.00019825283,-0.07648897,0.015617262,-0.014420508,-0.051110957,-0.034114987,0.005314862,0.018177507,-0.040710587,0.06725041,8.584554e-05,-0.036177203,-0.048585016,-0.017139364,0.10241096,0.02215554,0.043548502,-0.096155316,-0.0461778,0.03401695,-0.0865395,0.031188898,-0.05556907,0.025745181,0.096297555,-0.015114876,-0.07223381,0.027796173,-0.04170348,-0.0017147901,0.06735292,-0.00076095504,0.020773329,-0.049686752,0.017941,0.026107322,0.12692665,0.049707275,-0.03742857,-0.07091196,0.007998511,-0.0041984655,0.095918074,0.0076751877,0.031110754,0.006490029,-0.0367913,-0.017576046,-0.080618955,-0.01918759,-0.03900877,0.0142968325,-0.026437398,0.0024245128,-0.019667836,0.036074713,-0.086221196,0.026812073,-0.031180628,-0.09313003,0.0564352,-0.023222042,0.08169997,-0.060747135,0.08626158,-0.02422703,-0.039776195,0.041282482,-0.020771587,0.044068456,0.0307424,0.021346336,0.029592745,0.027873365,-0.04730956,0.027160605,-0.018052954,0.036968064,0.028129332,0.061306626,-0.0417392,-0.0007448195,-0.030549841,-0.13298349,0.033355806,0.012912649,0.12963352,-0.024328189,-0.047206372,-0.011465449,-0.005886094,0.012886902,-0.103805855,-0.06098604,-0.008448751,-0.05051224,0.16772653,0.0009307286,0.0016454078,-0.023890438,-0.050704993,-0.0014530438,0.01823782,-0.004422675,0.051564235,0.09678854,-0.07878762,-0.108069286,0.013486627,0.048429932,0.03703084,0.08288373,0.02952853,-0.013086421,0.008017539,-0.19788733,2.1920216e-33,0.041023735,0.0285987,0.020781035,-0.04885007,-0.00027040427,-0.0008833013,-0.092230536,0.09994577,-0.0020962178,0.01956752,-0.08036471,-0.014906559,0.09322555,-0.067727454,-0.061148953,0.023569984,-0.0131697515,0.017404512,0.04101148,0.043310303,0.056789774,0.12043103,0.047674913,-0.028730482,0.049086235,0.047338914,-0.003968717,0.00501055,-0.012807384,0.017437493,0.045195863,-0.14111808,-0.071200505,-0.01201843,0.13577291,-0.024464332,-0.018672626,-0.05738304,-0.020696634,-0.05326132,-0.011496464,-0.008102696,-0.015450744,-0.020053962,0.053209726,-0.05479522,-0.023340277,0.10075974,-0.0329985,0.03070106,0.02462908,-0.009748631,0.085559115,-0.046445288,-0.07578094,0.009892705,0.00792771,-0.0073632635,0.034105774,0.07060617,0.030043533,0.09032367,-0.035833403,-0.0026148828,0.0047318386,-0.048982985,-0.014351197,0.046253018,0.06072462,0.10329439,0.014740549,-0.013403485,0.047614213,0.040907245,-0.01757212,-0.0033415135,-0.050869863,-0.04082641,0.048537616,0.06521142,-0.056252167,-0.014935477,-0.020064771,-0.050298184,-0.072765484,0.017630683,-0.050151773,-0.0020838212,-0.016586471,0.03561136,-0.004067172,-0.033411913,-0.043066055,-0.0018702325,0.021654334,-3.659856e-33,0.040843327,-0.06656271,0.04377451,-0.09095408,-0.03355302,0.113131784,0.03518333,-0.0004597457,0.016281875,-0.0034253635,0.091705516,-0.026200276,-0.017039677,-0.070400186,0.06294445,0.03491164,-0.04745707,-0.022170981,-0.007139246,0.020238472,0.0081464015,0.10328928,-0.03086293,0.029923927,-0.028070154,-0.01732704,0.050249312,0.065307386,0.065934874,0.046399847,0.011904581,0.02394903,-0.0085368175,-0.07542982,-0.05287674,-0.014881582,-0.058331657,-0.01916989,0.06694378,-0.005722121,0.062239,0.024476169,0.004148568,0.046946328,0.04120714,0.029495122,-0.086595155,-0.003725925,0.0060689794,0.011608834,0.028115682,-0.04229028,-0.025511842,0.03646582,-0.0009107522,-0.029617393,-0.02117703,0.07616415,-0.03949332,0.06475639,-0.03320783,-0.104090765,0.016553944,0.050838143,-0.0055093914,0.009345687,0.0006845111,-0.029664103,0.037843324,-0.0039860085,0.023283562,-0.009478241,-0.011723218,0.023087094,-0.04107559,-0.034672078,-0.02717026,0.050021913,-0.028175011,0.012615526,-0.008553828,-0.026560368,-0.012999942,-0.07249004,0.07978548,-0.07256889,0.01561156,0.071014926,-0.03916201,-0.0017062443,-0.023955228,-0.022955766,-0.034841955,0.040322963,0.02362266,-4.2819934e-08,-0.020194558,0.0050397334,0.05611225,-0.00033409553,-0.022223545,0.024913607,0.014712813,-0.036775287,-0.025268132,0.03425572,0.07414463,0.080061406,-0.022494415,-0.008584862,0.007509783,0.022681134,-0.020545196,-0.0054766918,0.038391326,0.011312511,0.022407275,-0.030959306,-0.10126913,0.05787568,0.036104795,-0.05608906,0.012837651,-0.08204266,-0.01457436,-0.045013428,-0.014557838,0.02281249,0.023826499,-0.026917133,-0.018481722,-0.024951354,-0.045811255,-0.01327548,-0.03006266,0.013180718,0.026739415,0.04103414,-0.094920896,0.006066702,-0.0011781551,0.034851745,0.019895818,0.04308507,-0.07871708,0.02976456,0.08377222,0.012357406,0.0031580422,-0.0678129,-0.09679345,0.07784073,0.00814654,-0.11020149,-0.06299536,0.0588986,0.106600486,-0.04214026,0.12871163,-0.002105419 +1.12.2.1,"An iron-sulfur protein. Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also be reduced.",384,1.0,-0.043356944,-0.0076845293,-0.024355544,0.03277942,0.10216917,0.041536223,0.021684112,-0.023422008,-0.0071917595,-0.07319465,-0.02525381,-0.027978597,-0.03320628,-0.00091472245,-0.02942571,0.03598117,-0.046291072,-0.01057432,0.0029956053,-0.0719998,-0.0075880666,-0.001980934,-0.019651575,-0.015482631,-0.05379435,0.05799658,0.064403564,-0.08367106,-0.05074671,-0.04295139,-0.03418191,-0.09560708,0.051606834,-0.07238801,0.038745318,0.018600093,-0.008065898,-0.023854388,-0.095597915,-0.06281367,0.0385664,0.00920579,-0.02605188,-0.03812569,-0.0124147665,0.0055119456,0.04508617,-0.002418407,0.0064147483,-0.013051578,-0.06528534,-0.06378038,-0.031955354,0.06709259,0.061667405,-0.018556574,-0.06490119,-0.057185248,0.010464644,0.02321741,0.049262963,-0.022207273,0.013433844,-0.03821992,0.06800131,0.035920557,0.064436525,-0.03238434,-0.035113182,-0.06665541,0.008409813,-0.030363483,-0.038749024,0.036328543,0.01031663,0.073247574,0.058628865,-0.048316,0.10449595,-0.007988973,-0.06051579,0.038958393,0.072046384,0.08644997,0.042493533,0.04331919,0.0021669674,0.0188546,-0.0979147,-0.0009813724,0.036667265,-0.0011082214,-0.022911465,-0.029131064,-0.01203136,0.036567897,-0.05887591,0.064930856,-0.008831202,0.008429317,0.016423231,0.027422091,-0.024456857,-0.0914833,-0.07151718,0.06137404,-0.016701583,0.112236336,0.0504667,0.06999981,0.016118413,-0.026656395,0.009188004,0.0051299506,-0.010806575,0.037825413,0.09046728,-0.00804301,-0.08851334,0.0534944,0.046138108,0.062221397,0.06259401,0.06886233,-0.021322226,0.084150314,-0.13038652,2.6171424e-34,0.05183706,0.07649095,0.041769624,-0.059714608,-0.030157572,0.016288323,-0.106474265,0.09328347,0.029064987,-0.025774034,-0.041616388,-0.03941599,0.04684136,-0.068388514,-0.034541097,-0.067532726,0.005408362,0.015355429,0.07120036,-0.0053891987,-0.056417346,0.08430247,-0.049225092,0.024419725,0.028690008,0.0033481999,-0.037421275,-0.0146502685,0.013506274,-0.046823528,0.034066007,-0.09998458,-0.049285237,-0.0038318576,0.07391021,-0.030890096,0.06577891,0.014557141,-0.08694677,-0.0103216665,-0.025693797,0.013911245,-0.04881954,-0.0126380725,0.04226402,-0.1001297,-0.047736835,0.030468836,-0.009675695,-0.01853962,-0.021234902,-0.022796817,0.053286437,-0.08361793,-0.091189474,0.053520136,0.02171533,0.03675905,0.03470274,0.021059336,0.0051140417,0.04831482,0.00048282658,0.0195339,0.009373132,-0.013968935,-0.05442089,-0.035573743,-0.001666258,0.03525686,-0.087492585,0.06415158,0.06828345,-0.009013759,0.01703494,-0.12968795,-0.058394607,-0.09477396,0.05281148,0.023746708,-0.0060683116,-0.053278867,0.00590777,-0.014662043,-0.06815601,-0.028654184,-0.05361941,-0.0030805508,0.031057201,-0.09607206,0.016367028,-0.051035035,-0.10438881,-0.027863884,-0.04541519,-1.9579017e-33,0.03409383,-0.074749365,-0.018742044,-0.04549147,-0.028441802,0.033578873,0.090276,-0.033736058,0.028135376,0.0042693834,0.15019944,-0.061984055,0.06492846,-0.06358378,-0.00067793665,0.09721288,-0.037983745,0.07879346,0.06498611,5.360922e-05,-0.09411547,0.0846896,0.031438373,0.05727211,0.0006264887,0.047509704,-0.02329987,0.020209068,0.15113728,0.04996793,0.014825752,0.0139348535,0.007891274,-0.1012297,-0.022751972,-0.005514901,0.0031076323,-0.020209223,0.028048886,0.026928026,0.010650883,-0.0135813765,0.0511519,0.13680966,-0.009062013,0.06599024,-0.109108895,0.08723282,-0.033413697,-0.0013495372,0.046050496,-0.012146488,-0.069830365,0.042439215,0.005788187,0.006079752,0.045226175,0.046863038,-0.034406297,0.09118066,-0.058954936,-0.035107534,0.053105976,0.06166426,0.040973738,0.011562597,-0.059486385,0.053519316,0.04765483,-0.0545943,0.052878585,0.04271379,0.06395749,-0.018677006,0.0070124404,-0.040324572,0.02680254,0.022192635,-0.007819696,-0.0104757575,0.0063295024,0.036539517,0.006205522,-0.041494466,0.00911683,-0.023486704,-0.0141361505,0.07573556,-7.64278e-05,-0.0050316523,-0.03457061,-0.006751668,-0.050685365,0.085532464,-0.0981418,-3.541351e-08,0.046312656,-0.0856783,0.05939683,-0.033727795,0.013733258,0.010757565,0.07239984,-0.02017879,0.028275961,0.038772803,-0.0035127695,0.07367975,-0.11153501,-0.04976204,0.033340503,-0.0043572313,-0.006679238,0.033578716,-0.0073022055,0.038118806,-0.020875318,-0.0018142136,-0.08750258,0.013988857,0.028561374,-0.085585624,0.026614593,-0.03722717,0.003271156,0.010739895,-0.03270649,0.035199896,0.00818503,-0.044872206,-0.057498097,0.03752778,-0.0019337083,0.021789934,-0.04886548,0.046458602,-0.084724136,0.01499548,-0.088969715,-0.05166201,0.023325268,-0.09323149,-0.024648895,0.057789244,0.0235145,0.026338445,0.009242747,-0.0143314805,-0.010940285,-0.06161119,-0.07643596,0.069711685,0.07145359,-0.07922795,0.026641872,-0.010957486,0.02515594,-0.06272176,0.13046548,0.031793248 +1.12.5.1,"Contains nickel, iron-sulfur clusters and cytochrome b. Also catalyses the reduction of water-soluble quinones (e.g. 2,3-dimethylnaphthoquinone) or viologen dyes (benzyl viologen or methyl viologen).",384,1.0,-0.04940949,0.04600618,-0.015233376,-0.03383468,0.10478855,0.04274169,0.056554224,-0.0148013355,-0.006962364,-0.025746109,0.032110598,-0.04699097,0.016927255,-0.038824372,-0.03781916,0.05336321,-0.06815916,0.01490297,-0.038175922,-0.04281536,-0.042716503,-0.061340313,0.0021855712,0.01324558,-0.04225245,0.086430974,0.0740128,0.011355582,-0.021592943,0.0064523797,-0.009849476,-0.025044976,0.04409608,-0.034452587,0.01751219,0.010039823,0.00060179515,0.036883596,-0.0022819894,0.016195599,-0.04262492,0.0064272056,0.0380478,-0.03286129,0.062582575,0.009182465,0.06410825,0.0022913697,-0.06482723,-0.050382543,-0.057337154,-0.029478515,-0.053411286,0.120394975,0.05218711,0.056684952,-0.04926683,-0.034529302,0.010778014,0.074407525,0.029062577,-0.005711953,-0.05278032,-0.04576598,-0.025944037,0.047945585,0.014173461,0.013452046,0.033027865,-0.052378282,0.012520641,-0.030357793,-0.05093461,-0.058194887,-0.036789946,0.10369356,0.0367188,-0.0066366754,0.029528279,-0.011647587,-0.040333427,-0.008430584,0.105879456,0.12817332,0.06818733,0.058493182,0.02201544,-0.031660657,-0.025533449,-0.019298237,-0.0029691476,0.029723706,-0.040733818,-0.09755151,-0.06886597,0.09432349,0.021569803,0.0007727964,0.08299359,0.038100675,0.034118902,0.030886197,-0.014333202,-0.16172893,-0.08581876,0.037427906,0.062300038,0.16312943,0.052629836,0.0040742443,-0.03565979,-0.012181201,0.0030266058,-0.0060579036,-0.04802397,0.053887933,0.108604625,-0.024315828,-0.022729008,0.0434759,0.037960976,0.04828334,0.038463064,0.009849996,-0.019490786,0.04568179,-0.043996796,2.3355927e-33,0.03601967,0.051975124,0.033065323,-0.014815197,-0.018228997,0.04512766,-0.13181648,0.045230627,-0.060845546,-0.070399635,-0.06010207,-0.018423181,-0.0002793488,-0.00024647915,-0.029028147,-0.0337097,-0.0068991925,-0.035627052,0.007725615,-0.10083165,-0.011230686,0.04990744,-0.044075083,-0.018458046,-0.03961352,0.008562403,0.0067031207,-0.0093866475,0.048578072,-0.039970346,-0.005830649,0.029069742,0.005879835,-0.015831003,-0.070320345,0.05841286,-0.06281711,-0.040208433,-0.03184649,0.10335236,-0.015355712,0.0467509,-0.029078646,0.0052098655,0.036405448,-0.060783464,-0.04240872,0.045973655,0.006808475,-0.04528656,0.015154512,0.02434161,0.010092551,-0.0042863237,-0.108420126,0.049828824,0.09094731,-0.03758945,0.03245195,0.03262476,-0.01943348,0.03400827,0.015232626,0.023979966,0.04622131,0.005495833,-0.037118442,-0.0066668526,-0.037168723,0.03670211,-0.06467929,0.033245154,0.10682131,-0.043725867,0.010829218,-0.07639718,-0.016690537,-0.08388435,0.03993348,-0.0069515756,-0.032044586,-0.09539609,0.041966632,-0.026038531,-0.03071601,-0.08348953,-0.027687397,-0.061408233,0.016587224,-0.08585029,-0.02949709,-0.04313431,-0.06157087,-0.09341566,-0.036016256,-3.3843305e-33,0.010404772,-0.031001188,-0.08039334,0.0019512196,0.009134977,0.021642618,0.045615673,-0.08510329,0.007905424,-0.031186534,0.07539973,-0.06606753,0.045118287,-0.018686451,-0.08583902,0.013618094,0.06844189,0.077688985,0.09101778,-0.07143095,-0.024655182,0.020791037,0.036533784,0.02144931,0.01563569,0.024173317,0.008069517,0.011092543,0.08913711,0.11728571,0.01565224,-0.022791928,-0.0023640564,-0.033189368,0.021759275,0.053882305,0.018115344,-0.0035380751,0.01342586,0.048098832,-0.021699984,-0.083954155,0.026812896,0.11495035,-0.03264331,0.09203741,-0.08994462,0.08954702,-0.06135041,-0.03787026,0.066816166,0.037442848,-0.07684648,0.025726303,0.0405223,0.068087064,-0.013832349,-0.062851295,-0.017698132,0.0498817,-0.06171704,-0.025194151,0.03023071,-0.023403682,0.020895403,0.055526186,-0.017363118,0.12039423,0.0246031,-0.053139858,0.08622147,0.041529234,0.08041853,0.0017042388,0.0017693375,-0.020087771,0.020229986,0.011060542,-0.034975287,-0.02480611,0.07363083,-0.02966785,-0.029312262,-0.04753957,-0.08211002,-0.023488017,-0.053439774,0.09090028,-0.006208566,-0.01074055,-0.014300374,0.0546902,0.0071709156,0.06975654,-0.0039046097,-3.558691e-08,0.032193907,-0.06652575,0.042815506,-0.008014962,-0.0005759285,0.02962747,0.0634175,0.09103073,0.03723873,0.020458724,-0.030454101,0.021359567,-0.09358876,-0.025722636,0.034539957,0.018542232,0.031637225,-0.008342141,-0.053446133,0.0378008,-0.085695446,0.01414185,-0.08255363,-0.05377094,-0.021987384,-0.078956276,0.04004287,-0.03174932,-0.104742974,-0.008881551,-0.007140927,0.024217764,-0.026963862,0.0071903276,-0.030309752,0.06182447,-0.024190977,0.0013123763,-0.060881,-0.06098268,-0.07631308,-0.008405081,-0.103335656,-0.01984851,0.02582409,-0.08306621,-0.008328944,0.08066098,0.0156018445,0.03639865,-0.03128488,0.036102697,0.05197122,-0.014649921,-0.10382095,0.0488208,0.028844088,-0.033105467,0.018059596,-0.075736225,0.012750388,-0.06293985,0.17436013,0.030740678 +1.12.7.2,Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.,384,1.0,-0.013293081,0.016827164,-0.036481235,0.011083944,0.12841877,0.05030023,0.027314596,-0.036316365,-0.028912576,-0.04788193,-0.0075682574,-0.020274736,-0.032255024,-0.024985867,0.0014222786,-0.022065664,-0.0068096938,0.021909539,-0.009211661,-0.04287603,0.02754679,-0.0402247,0.013079438,0.011430889,-0.044506986,0.122466765,0.021241628,-0.069126874,-0.017179208,-0.044302132,0.005871641,-0.026489347,0.07036344,-0.10724035,0.013242152,0.06881367,-0.03916021,0.030033296,-0.056207765,-0.009921285,-0.015205246,-0.017887278,0.014818624,-0.039292768,-0.02423347,-0.017539872,0.014568215,-0.043880295,-0.02711193,-0.060042586,-0.06871604,-0.03300399,-0.057557553,0.05225775,0.041649595,0.00097428955,-0.03290887,-0.021129595,-0.03192328,-0.02398353,0.07356364,-0.031733356,-0.037475567,-0.03529177,0.018922267,0.018520964,0.107156105,-0.041874792,0.008722356,-0.065416746,0.0058781933,-0.045624252,-0.041776326,0.014829666,-0.014796281,0.073883906,0.105553426,-0.08785969,0.10460593,-0.0012757041,-0.036149602,0.09691226,0.046390567,0.06413263,0.003029488,0.067582525,-0.014484797,-0.06560577,-0.083034374,-0.032065444,0.0014996161,-0.013370496,-0.01692543,-0.049134076,-0.0121467365,0.07526794,-0.008939631,0.06803558,0.070865996,-0.009392438,0.04005052,0.09319333,-0.04123085,-0.13455969,-0.09112205,0.04230929,-0.011236711,0.13195947,0.07814534,0.09583572,-0.031259775,-0.0073304814,-0.053369954,0.01582281,-0.025254691,0.024001794,0.14807025,-0.034987208,-0.08377946,0.05808302,0.045852434,0.026148418,0.09735569,0.063979775,0.015347857,0.04835015,-0.09617696,-2.359909e-33,0.010684519,0.0021849065,0.062468875,-0.08670987,-0.03665282,-0.024156049,-0.08682438,0.06018091,0.062735975,-0.03625299,-0.052199278,-0.030006291,0.025256772,-0.04526712,-0.057092384,-0.05183841,0.023447746,0.020141697,0.051973443,-0.020721335,-0.06046526,0.057713192,-0.016117424,0.03280784,-0.031161293,0.00029062357,-0.011675218,-0.04336442,0.015390825,-0.04443508,0.0738134,-0.06746064,-0.058257658,0.055027895,0.080048226,0.049340952,0.033958092,0.018882714,-0.02373654,0.004891366,0.006474984,0.021056388,0.0071158702,-0.012123313,0.072388396,-0.06752039,-0.07947068,0.046423893,-0.0032068251,-0.04640606,0.039541222,0.032333832,0.052735068,-0.03981235,-0.094432905,0.08658275,0.044304907,0.047116052,0.03961678,0.046831064,-0.035878483,0.08048966,-0.011398219,0.07317441,0.030489553,0.0044131665,-0.046094384,0.01537663,-0.011312705,0.067476615,-0.09970216,0.041167807,0.053761955,0.053558193,0.032293856,-0.06544496,-0.026661934,-0.05748029,0.0620705,0.019452125,-0.047867768,-0.076386504,0.0016589131,-0.03034529,-0.05792847,-0.034885697,-0.033147637,-0.029813403,0.04779091,-0.076694116,-0.021763412,-0.04778831,-0.08637681,-0.03773312,-0.020594956,-3.5743337e-34,0.055855535,-0.04047094,-0.011416116,-0.031265877,-0.0038379787,0.03488046,0.02431291,-0.10241224,0.03999214,0.016303267,0.0887176,-0.06636416,0.03133927,-0.07551288,-0.045199607,0.05474288,0.0005433049,0.09513772,0.043080926,0.028817788,-0.073100515,0.049688384,-0.006182756,-0.015778305,0.046241026,-0.01854485,-0.0415586,-0.008069,0.15386763,0.027910326,0.011541625,-0.021022465,-0.022469275,-0.11297354,-0.04783911,-0.032437894,-0.043458674,0.0133450655,-0.0027106097,-0.025023876,0.01826756,-0.04065739,0.038941137,0.10732676,0.04056214,0.06953634,-0.08569066,0.05260192,-0.036765482,0.01546677,0.084075846,0.005080352,-0.05759643,0.004556853,0.034164347,0.027011596,0.0170772,0.03277302,-0.034139697,0.017521348,-0.05313098,-0.03676217,0.04236203,0.035489142,0.027583746,0.0060369316,-0.028069198,0.06808384,0.008318244,-0.035339918,0.033825815,0.06779872,0.10510956,-0.015791027,-0.019965343,-0.014428124,-0.016689137,-0.013256005,0.022569831,-0.017462267,0.04351362,0.021457076,-0.021343427,-0.03825298,0.035716835,-0.019387437,-0.0041481503,0.060039144,-0.020258103,-0.013405381,-0.046988428,-0.048184633,-0.0380078,0.06658068,-0.05857763,-2.7164425e-08,0.048520483,-0.055277202,0.03498396,-0.013941722,-0.005007265,0.06702184,0.058305148,0.05984969,-0.00667341,0.013304145,-0.035009544,0.09879694,-0.08377128,-0.02044329,0.057367202,-0.022956599,-0.012899995,0.026562404,-0.038580354,-0.0031613738,-0.042278554,-0.025252145,-0.0447117,0.02334377,0.043756742,-0.08585371,0.079934336,-0.025786394,-0.06791985,-0.06442982,-0.04561147,0.0082944855,-0.011047127,0.009820628,-0.022642432,0.027993461,0.018147048,-0.00997742,-0.028908992,0.022077724,-0.07084493,-0.008906018,-0.09539664,-0.034238573,-0.014069411,-0.06286226,-0.058506623,0.082227744,0.025401032,0.037643436,-0.017036263,-0.02110487,0.017916003,-0.08356037,-0.06814383,0.09537401,0.05424893,-0.10080791,0.02333058,-0.038097396,0.063557275,-0.029909024,0.1712441,0.016804693 +1.12.98.1,"An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F420, flavins and methyl viologen, but to a lesser extent. The hydrogen acceptor coenzyme F420 is a deazaflavin derivative.",384,1.0,-0.05897037,-0.014631387,-0.090082176,0.04652843,0.10939453,0.015217873,-0.01746178,0.0598765,-0.016603295,-0.06668848,0.015063621,0.03656883,-0.067996286,-0.018575357,-0.06377484,-0.0073332796,-0.015599805,0.025416233,-0.06486142,-0.022244196,-0.053136416,-0.015540025,0.034288302,-0.027051933,-0.04856777,0.018798128,0.0115001695,-0.04593317,-0.030229213,-0.048274238,0.07053751,0.009284262,0.085377075,-0.042265788,-0.031131782,0.013714161,0.02887096,-0.029983817,-0.04681034,-0.021063164,-0.019336522,-0.006096752,0.031810753,-0.041288078,0.050781313,0.0033698478,0.0035351743,0.03917254,0.00017044459,0.04768118,-0.007029911,0.0060435543,-0.08232075,0.042508494,0.030667014,-0.0065631075,-0.0065128068,-0.10703245,-0.03589572,0.01971096,0.04212491,-0.052820142,-0.031014519,-0.023937948,0.050323818,-0.01022151,0.027817534,-0.07144459,0.028840635,-0.019330474,0.051033825,-0.032354508,-0.081890576,0.031151244,0.020324519,0.055342905,-0.0049827877,-0.060372394,0.093368076,-0.004357909,0.066881396,0.0025819533,0.10974215,0.056799635,0.044810116,-0.0061683506,-0.041206274,-0.03070761,-0.049275983,0.04937291,0.008199626,0.017392542,-0.0042212694,-0.00027669236,-0.08166241,0.08065632,0.015814656,0.024571933,-0.06668292,0.053481292,-0.04444197,0.033937354,-0.016650517,-0.04380262,-0.06476239,-0.019795427,-0.018152788,0.124740645,-0.028525403,-0.007468106,-0.00037345872,-0.040236313,-0.011318081,-0.050840233,-0.015003578,0.014384814,0.054269057,-0.0537606,-0.007876418,0.008777368,0.0145633565,0.11898276,0.058414206,0.112831384,0.028236246,0.030876096,-0.14121522,4.6138965e-33,0.054433852,0.047559626,-0.016098872,-0.04948615,-0.010478209,-0.0058223982,-0.090327606,0.05226764,0.028777061,-0.025827145,-0.078852504,-0.019758519,0.058490485,-0.08836996,0.0074903374,-0.088412814,-0.027980478,-0.017361907,0.10268551,-0.089419656,0.040537924,0.08143712,0.01050511,0.04376824,0.039413434,-0.005706934,-0.061138272,0.06647619,0.041311,0.014942965,0.03520531,-0.056740675,-0.05444867,-0.025723701,0.03319913,0.052959297,-0.067310505,-0.045440692,-0.11381977,0.06195788,0.0149061745,-0.011375773,-0.036683377,0.024688607,0.050012395,-0.08272647,-0.052155595,0.091118604,-0.008730451,0.052846167,0.035820287,-0.0112865,0.036828708,0.031829823,-0.09819142,0.007480922,-0.004390331,0.0057849805,0.032856155,0.014322106,0.036878213,0.042421006,0.002571032,0.086885236,-0.02512295,-0.02071813,0.0058919806,-0.0708204,-0.03583585,0.08681818,0.01733853,0.0077646794,0.08940054,0.027580481,0.045515038,-0.07755387,-0.038430415,-0.081803456,0.031055303,-0.020387579,-0.03395677,-0.031194987,-0.024153348,0.007882245,-0.050500013,-0.01849264,-0.062060345,-0.053191796,0.076190315,-0.071091525,-0.01913981,-0.054221217,-0.031012723,-0.026193436,0.04569895,-3.2204504e-33,8.391273e-05,-0.08466525,-0.0025969173,0.044942833,-0.0073106186,0.040851668,0.04292232,-0.04222697,0.036551625,0.00089997734,0.107519746,-0.092019804,0.0030029146,-0.03266663,0.009719058,0.060076546,-0.0446073,0.0012193357,0.03076178,0.024810372,-0.08504848,0.05023558,0.048039652,0.073567145,0.028297791,0.00839503,0.0107396655,-0.053484004,0.07774844,0.081568554,-0.03499135,0.019767245,-0.036175318,-0.043131612,-0.08727018,0.060037307,0.013034377,0.020493446,-0.027810855,0.014746996,-0.053808972,0.045095295,0.029356781,0.089465775,0.05409651,0.05291225,-0.07727157,0.055649944,0.03916138,-0.028460864,0.04562679,0.0052296263,-0.027296528,0.08156647,0.010763907,0.024877165,0.07045866,0.045695305,-0.040073413,0.075660594,0.010664944,-0.08684433,0.035742503,0.020206878,0.13096988,0.041511256,0.0033492919,0.12292349,-0.009705299,0.0015596804,0.10925374,-0.008715276,0.049169503,0.05065139,0.03306735,-0.050211124,0.033275053,0.08712627,-0.03902717,0.053658474,0.045781247,-0.00897676,0.010487309,0.0500926,-0.072258554,-0.121745266,-0.036264118,0.093904436,-0.0009969203,0.03447731,-0.042434674,0.013780038,0.0024018849,0.011576436,0.0062451884,-3.665493e-08,0.003888175,-0.027720353,-0.016675185,-0.025372233,0.056243423,-0.0014677723,-0.007579704,-0.07867303,-0.025941156,-0.035593003,-0.07764414,0.16036533,-0.05962315,-0.041713387,0.04549938,-0.02870712,0.008325971,0.04444513,-0.037461184,0.033104546,-0.040709864,0.08793389,-0.076939195,-0.02809232,-0.033675846,-0.029410357,0.0047204904,-0.033424467,0.058098543,-0.016297089,-0.0051137,0.047438193,0.019583179,-0.07316823,-0.1320559,0.051935658,0.0732921,-0.038677998,-0.080196,0.08764017,-0.09479175,-0.01677523,-0.052795,-0.043015897,0.014472653,-0.063976035,0.01842242,0.00034641993,-0.0389518,0.00154719,0.008519756,-0.0029854698,-0.004271215,-0.012534752,-0.06082212,0.009854134,-0.0007726121,-0.097204946,0.0005699598,-0.056556877,0.02979766,-0.019641837,0.13582273,0.03216608 +2.1.1.167,"Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2'-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 [1]. ",384,1.0,-0.027395178,-0.080782205,-0.09396404,-0.028488869,0.018356506,0.0682722,-0.03209323,-0.02459342,-0.0054910406,-0.01868569,0.021358896,0.056381866,0.0069787535,0.041371405,-0.0269987,0.09535483,-0.110601895,-0.063682206,0.11600659,0.010673372,0.048134454,0.07351354,-0.03930979,0.038348958,0.014720154,-0.02191187,-0.004662007,-0.005624866,0.0046833185,-0.04258629,0.059037503,0.03536906,0.0063221194,-0.042362023,0.058903325,0.0233191,0.0022227336,0.0141628245,0.048762824,0.02017417,0.012932724,0.04033742,0.00944999,-0.01871977,0.0003995557,0.0017099556,0.028695904,0.071481116,-0.0637918,-0.009236434,-0.008372882,-0.042971384,-0.008469049,-0.020885024,0.13407765,0.062649384,-0.09262666,-0.010584253,0.0043929503,-0.026098471,0.01271259,-0.057500493,-0.013081428,-0.0692857,0.07706691,-0.05978153,0.078384236,-0.060446795,0.030399106,0.01378269,-0.08688451,0.0013420195,-0.08414856,0.10136849,-0.010357181,-0.008535731,0.0067847385,0.018545799,0.042088076,-0.04901949,-0.006147882,-0.04216621,0.014506276,0.0377349,0.008830333,0.024628233,0.03339489,0.090803936,0.046660487,0.012718028,-0.005714887,0.045905214,0.076251656,0.034713704,-0.07239609,0.06270877,-0.030271735,0.06142496,-0.0038614117,-0.03310262,0.03540718,0.056076888,-0.011637333,-0.061910108,0.013634907,-0.04260362,-0.0077607315,0.09324047,-0.03925564,0.05824048,0.03903842,0.042279348,0.03281506,-0.014541603,-0.042261172,0.045139797,-0.028228931,-0.003144707,-0.019096663,-0.04701346,-0.04347778,0.027819622,-0.0411343,0.041272897,-0.12145873,-0.06270968,-0.10149525,2.0271758e-33,0.04728412,-0.01417998,0.02755366,0.057149366,-0.039451085,0.006709833,-0.013081296,-0.025783282,-0.04246739,-0.09918029,-0.14669284,-0.13122909,0.02280709,0.014432185,-0.07855292,-0.042252373,-0.07845792,-0.014510235,0.023108298,-0.008341399,-0.046431817,0.04620569,-0.03633973,-0.03257139,0.051159214,-0.0459434,0.002187647,-0.099672474,0.031919867,-0.037068762,-0.030769486,-0.016267177,-0.13581152,0.029898137,0.02500242,-0.08373795,0.021456346,-0.04488415,-0.033766814,0.11940387,0.011848284,0.030432845,-0.03257751,-0.00066742214,0.07054565,0.03239035,-0.027160555,0.08672173,-0.030923372,0.07977683,0.034121115,-0.009583285,0.04275423,0.01798758,-0.078969,-0.036477007,-0.011155044,-0.06991779,0.02849681,0.017010624,0.022859389,-0.010172237,0.05739287,0.027801892,-0.0032555126,-0.05135886,-0.04271496,-0.09370876,0.038117386,-0.027546901,-0.026950078,-0.029268974,0.13605013,-0.05604309,0.0037342242,-0.060017087,-0.052936833,-0.011923732,0.044441123,0.07427544,-0.09203814,-0.06783036,-0.010639021,-0.03366977,-0.031864773,-0.025796013,-0.013456431,-0.10556368,-0.03310106,0.048978046,0.0061263377,-0.054549485,-0.054676868,-0.0037123857,0.07363674,-2.2550046e-33,0.0418456,-0.08461227,0.07654934,-0.037879534,-0.06555922,0.0062106294,0.065427445,-0.13077714,0.012547514,-0.008226766,0.028504401,0.033835433,0.033392448,-0.089794956,0.018862149,-0.056776885,0.0373333,0.023443198,-0.023883848,0.028764144,0.011456794,0.08438378,-0.10919042,0.11200365,-0.03393281,0.05095674,0.042876955,0.04199985,0.11493282,0.027403856,-0.012352976,0.03530254,-0.030767035,-0.004643006,-0.053752635,0.05948963,-0.02302498,0.013713505,0.014056494,0.0049624383,-0.056432046,0.054667924,-0.10517637,0.09671063,0.012025793,0.056175265,0.0107109025,-0.00380484,-0.033135068,-0.067176886,0.049520347,0.044345886,0.03512704,0.010762808,0.06397315,-0.049825188,-0.05462894,0.0055610132,0.0030476812,0.008246377,0.025297958,0.047909293,-0.041763507,0.011515403,0.03476937,0.07920509,0.02133908,0.053182606,0.0060137343,-0.034931824,0.022567462,-0.0152611565,-0.017025605,0.014817228,0.035184696,-0.045920808,-0.07805547,0.008195763,-0.025751568,-0.003836653,-0.040256217,0.0052945353,0.012559757,-0.0009956401,0.11449197,-0.0716412,0.02079672,0.06385442,-0.013314004,0.041185617,-0.040480863,0.026490191,-0.029870553,0.062368486,0.009623739,-3.875004e-08,-0.018359685,-0.025807519,0.013989829,-0.0188295,-0.03939516,0.039244097,-0.004265614,0.07060733,0.068717465,-0.042006552,-0.050158627,-0.027555076,0.027276749,0.004714302,0.086333886,0.073932,-0.06660076,-0.008650088,-0.05178364,-0.04177285,-0.039663605,0.0014276137,-0.08240754,0.047760617,-0.028358966,-0.024545636,-0.0077864937,0.11633607,0.093116306,-0.093569696,0.05303816,-0.013785515,0.06388786,0.02564944,0.02280203,0.05201265,0.09352441,0.011599137,0.0725105,0.049117506,-0.026047772,-0.0454913,-0.033562724,-0.014673065,-0.053368196,-0.006743339,-0.06686072,0.0576741,-0.005503306,-0.0041900882,0.082873024,0.09328399,-0.043722708,-0.013192988,-0.060072087,0.056768764,-0.04556933,-0.040470444,0.04324782,0.038493667,0.0068188533,0.028585818,0.06830606,-0.054053567 +1.12.98.2,Does not catalyse the reduction of artificial dyes. Does not by itself catalyse a H2/H+ exchange reaction. Does not contain nickel or iron-sulfur clusters.,384,1.0,0.004163298,0.017836062,0.0054457975,0.0115094595,0.10784677,-0.0006058995,0.06158726,-0.014049737,-0.026756348,-0.007008505,0.003557861,0.071262024,-0.0017298156,-0.065277375,-0.03703411,0.081477225,-0.07066252,-0.011876202,-0.04508523,-0.03673424,0.0038422572,-0.17176653,0.014911361,0.005840514,-0.04284599,0.073133394,0.02736655,-0.016000139,-0.04915339,-0.03549702,-0.012686068,-0.05584032,0.057419036,-0.07390556,0.04220331,-0.013379531,-0.0063551334,-0.005458382,-0.03365243,0.0035152498,-0.010850765,-0.016745564,-0.035799522,-0.08741677,0.023140732,0.014734774,0.045349717,-0.028052881,-0.11723521,-0.08047966,-0.06132451,-0.011834298,-0.03304294,0.022354223,0.03607708,0.05631376,-0.01931146,-0.010585555,0.045166485,-0.02294469,0.01730726,-0.060408574,-0.03683,0.0077702957,0.07570124,-0.0053763427,0.02085154,-0.03635784,0.04046297,-0.04167116,0.03377078,0.0030401286,-0.030998308,0.02859088,0.059642177,0.050738584,0.07918927,0.029255578,0.05111589,0.02746479,-0.043009676,0.008474688,0.07784168,0.08189823,0.025803016,0.017369859,-0.040920876,-0.034995522,-0.053280596,0.019073388,-0.032507535,0.02588149,0.0052692113,-0.029591193,-0.030310879,0.0462114,0.067752235,0.087332875,0.07364613,-0.022365998,0.059141226,0.0584366,-0.12095329,-0.18074737,-0.073380336,0.03330102,0.013652056,0.12351419,0.03786043,0.010238231,-0.019698046,-0.046061732,0.03310836,0.010640657,-0.066800855,0.107904196,0.11230242,-0.03894863,-0.07000315,0.040350005,0.09500421,0.015436343,0.030318012,0.020036535,-0.057637166,0.009761228,-0.077127345,1.0691615e-33,-0.038612332,0.036961094,0.0372488,-0.08785547,0.020591758,-0.0027272392,-0.16446485,-0.0046876073,0.029911896,-0.059021533,-0.03296253,-0.03197324,-0.0036994796,0.010616479,-0.04925976,-0.058156893,0.045939896,-0.030730138,-0.013614959,0.016710317,0.005138026,0.081059575,-0.008905601,-0.010351417,-0.021473067,0.016927674,-0.018255183,-0.0100277215,0.05248395,-0.031084387,0.035129536,-0.024941346,-0.061016347,0.04572299,-0.047004838,0.036088403,-0.0150898015,-0.031260125,0.0020353138,0.050677992,-0.028257404,0.068547115,0.002590721,0.06774513,0.05248957,-0.02519139,-0.013963132,-0.0076327934,0.069174334,-0.0034929728,-0.026950367,0.03921884,0.03812851,-0.050261907,0.03958127,0.0537486,0.03722052,-0.04349172,0.03082853,0.037285116,-0.03907612,0.025902366,0.040637232,0.03631154,-0.009466326,0.018404864,0.03575518,0.010689559,0.042015214,0.012664585,-0.05796997,0.07737191,0.058686588,0.009910658,0.010691845,-0.045747183,0.023806244,-0.07745695,0.090732604,-0.011550948,-0.025256727,-0.012829185,0.013104145,-0.03369853,-0.02766183,-0.088522494,-0.08731982,0.012855459,-0.031629506,-0.028122803,-0.022549165,-0.04315479,-0.074614115,-0.06910035,-0.02867535,-3.3388984e-33,-0.02060159,-0.013985204,-0.09694915,-0.027540673,-0.03025055,0.019693129,0.017198542,-0.045670345,0.05628304,0.0013465898,0.071352854,-9.285523e-05,0.0199786,0.045223914,-0.033787966,0.033520825,0.0155170495,0.0633076,-0.0020934625,-0.07647321,-0.047609214,0.05829719,-0.036385365,0.013242383,-0.011304698,0.054680448,-0.031609442,0.025392527,0.17906493,0.06808664,0.027912214,-0.03607174,-0.037539896,-0.023854267,0.044058554,0.05256732,-0.0014369963,0.017994659,-0.0096735135,0.034511227,0.031024335,-0.09673993,-0.033571847,0.024173696,0.011717906,0.029324725,-0.09320624,0.051208034,0.0040494744,0.013102251,0.043360632,-0.0064101256,-0.04768012,-0.004312021,0.029516848,0.0066771684,0.06773694,-0.03451521,-0.12511699,0.07542874,-0.057676803,0.0065631103,0.027439823,0.0048117726,-0.030087875,0.029486004,0.02240011,0.05818958,0.0048473254,-0.12386678,0.13332938,0.042261016,0.025027905,-0.054515287,0.073788576,-0.014074856,0.015147927,0.05036095,-0.025087932,-0.035850674,0.06550427,0.04653241,0.03935035,-0.1118786,0.01944241,-0.037313137,-0.08157201,0.06258727,-0.040870316,0.025064923,0.061206214,0.018974492,0.062212348,0.05654126,-0.030516962,-3.092657e-08,0.020006247,-0.04640288,0.109010056,0.012456861,-0.010064454,0.01942426,0.02522537,-0.02013159,-0.031407546,0.020413298,-0.043230608,0.03137076,-0.008054043,-0.028931756,0.017352477,-0.028521916,0.058095187,-0.07214469,-0.066777945,0.022200724,-0.088828735,0.039591104,-0.16164555,0.00026964914,-0.04038649,-0.06876693,0.070085935,-0.044021778,-0.08812374,-0.07262882,-0.016074635,0.06435199,-0.026823154,0.034937873,0.0008592331,-0.0346858,0.028078282,-0.0136812655,-0.037584007,-0.04916296,-0.09235109,0.030829404,-0.053530734,-0.010700203,0.039069396,-0.05023191,-0.07655285,-0.0011435084,-0.024980765,0.065818325,-0.0038013887,0.0130622685,0.0013371117,-0.0400616,-0.0863234,0.019132681,0.04092043,0.05584063,0.008907661,-0.052546665,0.048554953,-0.10061723,0.1359244,-0.013148233 +1.12.98.3,"Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine.",384,1.0,-0.020409804,-0.055813614,-0.08193524,0.01677809,0.07881399,0.04193691,-0.01985067,0.0039440785,-0.006501459,-0.08786936,0.048235822,-0.0552708,0.033393532,-0.040649243,-0.02473111,0.040367227,0.022541782,0.002755201,-0.025152355,-0.048796624,-0.014284315,-0.011177311,0.023920214,0.025792496,-0.010005405,0.048621483,0.028827468,-0.053893737,-0.078714184,-0.05948245,-0.057815377,-0.056016713,0.09587447,-0.03519011,0.078515366,0.030045917,-0.030409735,0.011296368,-0.04443109,-0.056077044,-0.021505337,-0.003332549,0.0012756002,-0.013332114,-0.04995548,-0.03749411,0.016294628,-0.008548261,0.0027023186,0.0418112,-0.047797732,-0.048066847,-0.10786973,0.07517438,0.039418336,0.026243076,-0.06478371,-0.011275108,-0.025129287,0.035493307,0.026975729,-0.010908422,-0.0023072225,-0.021079449,0.04872209,0.0043732,0.08356087,-0.027962219,-0.0016594798,-0.1025902,0.023170695,-0.083100356,-0.018676002,0.031660557,-0.056433275,0.05484707,0.036247816,-0.07383194,0.078507185,-0.008042827,-0.05726596,0.028407576,0.06313825,0.13530478,0.03974498,0.053144224,0.021661732,0.021014027,-0.084171586,0.01648222,0.06010853,-0.02468122,-0.06351713,-0.0677562,0.025245888,0.057827875,-0.003168578,0.07780603,0.020120291,-0.039920162,0.041386403,0.057957813,0.014615568,-0.07435454,-0.05946098,0.051694687,-0.033883177,0.07372981,0.0641992,0.0068259807,0.008439793,-0.0076289615,-0.006221884,-0.00051851454,0.018300366,0.02499409,0.122320466,0.009417932,-0.06041271,0.0765275,0.020378752,0.06439091,0.089349404,0.06864713,0.0031821309,0.039685264,-0.09442127,6.7506404e-34,0.036139674,0.03252029,0.0681169,-0.03146759,-0.086881645,0.039729174,-0.064535365,0.12880675,-0.019745769,-0.06144329,-0.12628363,-0.049998973,0.091727994,-0.047677893,-0.0036669618,-0.028481109,-0.012975374,-0.013042197,0.07292427,-0.026217913,-0.015739655,0.026938975,-0.02797035,0.0027853234,-0.056811865,-0.022113508,-0.021597583,0.0072168843,0.031533826,-0.011488345,0.024109282,-0.06844998,-0.056815393,-0.028711377,0.07851106,0.06991098,0.033814784,0.012435832,-0.096777305,0.041039303,-0.015840631,-0.015433329,0.0069625243,-0.045081995,0.023313435,-0.117465466,-0.11001613,0.049656883,0.036712214,-0.01616155,0.021788122,-0.049129266,0.0770274,-0.012452626,-0.06829053,0.07313095,0.028778445,0.05354295,0.04034225,0.097487666,0.01668834,0.067291394,-0.028827317,0.014396837,0.044275485,0.058046177,-0.08534054,-0.015320291,-0.065333545,0.068626605,-0.04955232,0.025737725,0.05955767,0.014754627,-0.0019696492,-0.037479237,-0.087505445,-0.009750572,0.04805131,0.017248925,-0.012624665,-0.090280324,0.025330784,0.0011415302,-0.07663666,-0.041150276,-0.01751977,-0.016706293,-0.007840854,-0.016994312,0.009123319,-0.056296434,-0.08078982,-0.03978148,-0.052945998,-1.9670847e-33,0.064766265,-0.08221536,0.03798958,-0.041023567,-0.00845245,0.02817389,0.033662546,-0.0715413,0.03818007,0.041345555,0.08894229,-0.04612139,0.01249071,-0.07598301,-0.050277255,0.07427506,-0.019632865,0.10883898,0.087736025,0.024852643,-0.059318222,0.01441594,0.015228535,0.017199844,0.042059377,0.012227915,-0.015352206,-0.01501568,0.10684532,0.061088223,-0.028307987,-0.013049321,-0.024709677,-0.047696404,-0.068313666,0.060721286,-0.066925906,-0.051136006,0.047519613,0.0150668025,-0.043141555,0.047992367,0.05335154,0.1386727,0.093180574,0.045968805,-0.08102442,0.12943695,-0.053751636,-0.009665004,0.070949204,0.0027625184,-0.037101626,0.02840285,0.023671702,0.073159195,-0.03971886,0.032853205,-0.058685992,-0.01939982,-0.055381052,-0.03655106,-0.020302081,0.0092831,0.032770835,0.033310045,-0.058725473,0.049559817,-0.027688446,-0.029329581,0.03367394,0.01659252,0.0445381,-0.0044379537,-0.027805615,-0.0623651,-0.0001951857,0.034013726,0.014004618,0.002048128,0.027643476,0.025701212,0.008476669,-0.019918002,-0.009466886,-0.006232071,-0.014121868,0.09471235,0.047809955,-0.028974479,-0.07542106,-0.013736198,-0.050925415,0.06362042,0.02730066,-2.4335353e-08,0.07110069,-0.054485798,0.03826314,-0.03570938,0.069811836,0.04751575,0.09167073,0.008977849,0.0012487251,0.03467586,-0.04100628,0.08999189,-0.11567046,-0.056230508,0.029331729,0.023422712,0.0027478596,0.01359466,0.0035857745,0.030583594,-0.018772248,-0.018018514,-0.038184807,0.027787864,0.010324104,-0.079777785,0.001586869,-0.035359,-0.012112453,-0.009008079,0.0003184855,-0.044322025,-0.01568458,-0.08321238,-0.050272606,0.024523305,-0.020299578,-0.01937209,-0.0131227365,0.046671987,-0.033723664,-0.04800837,-0.065086395,-0.032453835,0.016142506,-0.0912417,-0.024083821,0.059402663,0.005953335,0.00091716537,-0.036939684,-0.054072317,-0.027596166,-0.037531875,-0.05924131,0.04791614,0.037175674,-0.13684192,0.042483848,-0.031287033,0.007925037,0.024672708,0.16951036,0.02834461 +1.12.99.6,Uses molecular hydrogen for the reduction of a variety of substances. Contains iron-sulfur clusters. The enzyme from some sources contains nickel.,384,1.0,-0.023686467,0.03668421,-0.02066843,0.0021766436,0.12657386,0.0595966,0.035039827,-0.007771943,-0.010984324,-0.046675745,-0.0040703854,-0.013388941,-0.0758058,-0.038684808,0.0011117577,0.0006628755,-0.008324553,0.019262144,-0.00046478532,-0.06320683,0.032806013,-0.055345464,0.022900354,0.029028462,-0.04874285,0.111015946,0.040288452,-0.024456661,-5.5022632e-05,-0.043557517,0.034241002,0.0027081226,0.06910699,-0.1097256,-0.028380742,0.07028387,-0.051909063,0.022109248,-0.065539196,0.0009088663,-0.02576015,-0.03523644,0.0034151904,-0.0078067393,-0.01984775,-0.024629526,0.019482233,-0.027698066,-0.012754846,-0.058978863,-0.029704766,-0.010888537,-0.035230692,0.012052506,0.024038823,0.0036663706,-0.030643756,-0.012695803,-0.021997696,-0.04299153,0.060455076,-0.013252993,-0.060463153,-0.041843776,0.019508693,-0.0073461514,0.111287884,-0.061220337,0.02561405,-0.04083037,-0.014513872,-0.035857093,-0.027763138,0.013824341,-0.010211342,0.048397817,0.09084763,-0.09431217,0.110994264,0.0034648878,0.0018050201,0.0840402,0.027788097,0.06808588,0.028767746,0.08726631,-0.0065685795,-0.09281987,-0.06642358,-0.06631057,0.0035763814,-0.041368082,-0.0022234037,-0.04937311,-0.041283242,0.07663432,0.009301915,0.06495829,0.09525636,0.006685836,0.057933632,0.087194026,-0.06453306,-0.12395935,-0.106991194,0.037726387,-0.018499251,0.13414933,0.09153359,0.088120185,-0.052875713,0.010447097,-0.072469845,0.016509337,-0.012971064,0.009014294,0.12852637,-0.022382831,-0.06016647,0.07340847,0.026148666,0.012323146,0.079804905,0.056342006,0.003486438,0.042270694,-0.101119295,-3.1308528e-33,0.013657702,-0.006889223,0.0565373,-0.07005177,-0.042771462,-0.024974456,-0.09039558,0.06782311,0.059737872,-0.061252322,-0.021868778,-0.020358754,0.038358398,-0.046475157,-0.072090246,-0.04901139,0.02194313,0.03548053,0.050343182,0.0055042123,-0.07967318,0.051118873,0.0038084364,0.06650506,-0.030680401,0.0021157942,0.0068636206,-0.023425793,0.027540179,-0.025759397,0.065493,-0.0599787,-0.07018507,0.06016662,0.067155026,0.046548475,0.012039766,0.0031677717,-0.0074635455,-0.007931637,0.011031834,0.044570357,0.02725531,-0.0006744532,0.060783524,-0.056955922,-0.04031393,0.045906004,-0.001339506,-0.038429882,0.040217347,0.02991824,0.05641172,-0.040896267,-0.061304107,0.07791369,0.04265074,0.029189061,0.044004053,0.042591996,-0.059953474,0.09568148,-0.010106766,0.094455615,0.028940214,0.00654093,-0.045484073,0.0001784017,-0.016290054,0.070083335,-0.091844626,0.027102742,0.05345944,0.043684322,0.020955844,-0.047400136,-0.010279619,-0.070340335,0.05784569,0.01033134,-0.050105777,-0.06959935,0.01957636,-0.036032353,-0.055171967,-0.06064054,-0.04077225,-0.056754928,0.039888054,-0.03966734,-0.0032044807,-0.07422791,-0.06285905,-0.06691124,-0.015164629,-1.1951715e-34,0.026348285,0.0004362485,-0.028099021,-0.010778517,0.008764143,0.025255645,0.032272354,-0.106804974,0.02624551,-0.005453773,0.078155674,-0.062859625,0.033036347,-0.055322953,-0.03451749,0.04640084,-0.016579106,0.05042927,0.013043265,0.029871553,-0.058054317,0.062782355,0.022107566,-0.03261041,0.02332118,-0.054374844,-0.049414508,-0.023828516,0.14127532,0.011405497,-0.020420011,-0.055277657,0.004509705,-0.103745125,-0.021514904,-0.02870986,-0.030413577,0.038312357,-0.017685903,-0.032091692,0.010054714,-0.0466762,0.046372082,0.08740754,0.01787486,0.093209095,-0.09660795,0.04372539,-0.001283912,0.000955066,0.08702634,-0.041618288,-0.046804532,-0.019645972,0.011090029,0.02688474,-0.012561715,0.030962365,-0.03006201,0.04969489,-0.039380264,-0.04627831,0.038474027,0.061809584,-0.010542448,-0.014162565,-0.027737888,0.03080867,0.006494385,-0.05387938,0.041825186,0.078877464,0.12526125,0.016295407,-0.039644755,-0.028982664,-0.009949862,-0.032638118,0.011472893,-0.008177922,0.04368449,0.019553255,-0.0428326,-0.050955653,0.023093397,-0.032946296,0.014355695,0.07170308,-0.053967502,-0.027767777,-0.014326077,-0.0022625527,-0.06044269,0.07261742,-0.05093333,-2.6032458e-08,0.04472403,-0.063452244,0.06911853,-0.05765783,-0.0011143237,0.07346139,0.07252691,0.07351074,-0.0007350235,0.0036081262,-0.030683411,0.11325478,-0.073254466,-0.0079084225,0.05270393,-0.024769776,-0.01774818,0.025136646,-0.056601364,-0.016623475,-0.04805781,-0.024250733,-0.05431551,0.02854687,0.061321687,-0.07987028,0.096956745,-0.0068123876,-0.07656067,-0.07015776,-0.031956326,0.013282953,0.0037876915,0.03831979,-0.017758248,0.03858964,0.009720361,0.006738258,-0.027753718,0.047861718,-0.050345,0.021458538,-0.102858596,-0.025976753,0.0006669043,-0.0589298,-0.060694687,0.09652751,0.0009178725,0.06829887,-0.026563287,-0.026303174,-0.0016745044,-0.07459222,-0.049972657,0.080951884,0.030912613,-0.11883872,0.02089102,-0.059259985,0.06878361,-0.014079113,0.15293919,0.023081826 +1.13.11.1,Requires Fe3+. Involved in the metabolism of nitro-aromatic compounds by a strain of Pseudomonas putida.,384,1.0,-0.022178536,-0.049249336,-0.09643235,0.025839336,0.06732984,0.03773504,-0.01871732,-2.785673e-05,0.025622705,-0.104122534,-0.02655354,-0.03655403,-0.10049523,0.042798486,-0.02551597,-0.034499653,-0.022574415,0.018838413,0.0046038805,0.054046012,0.033497237,0.05958843,-0.025059348,-0.016329326,-0.083252035,0.04923157,0.042193234,-0.018189512,0.002350439,0.001575024,-0.022714974,-0.015950436,0.018850032,-0.13500856,0.011883156,0.018922316,-0.034776255,0.029440444,0.023883902,-0.020480534,-0.014303282,-0.03914893,-0.031509027,-0.04362811,-0.018700747,-0.07523436,0.05674936,-0.0047095967,0.08058393,-0.069070086,-0.077218436,0.008288021,0.034442116,0.0484486,0.021524776,0.007194528,-0.0047692405,-0.041011404,-0.07356259,0.008704797,0.007059933,-0.049105812,0.013084857,-0.024133703,0.024644539,0.035017382,0.0712988,-0.03028902,0.02644809,-0.011017848,-0.030582175,0.010500171,0.038475152,-0.006734859,-0.041364074,0.0147734275,0.07908771,-0.022634113,0.07021555,-0.050192058,-0.022273531,0.01535397,0.012415706,0.09668666,0.014697861,-0.010517022,-0.047043543,0.04295849,-0.019744294,0.11318348,-0.043431047,0.037883986,-0.012680324,-0.033086598,-0.017491763,0.06766823,-0.0011546168,0.054974888,0.034235507,-0.004169104,-0.01120091,0.077450186,0.012757196,-0.030399054,-0.08788639,0.015215791,0.034787558,0.07257375,0.012587598,0.041978903,0.05466529,0.01659766,0.008126493,-0.057246257,-0.030237546,0.013595319,0.059824597,-0.085899785,-0.09457249,0.001536955,0.010486635,-0.0072110742,-0.022162477,0.06162666,-0.070582055,-0.007396143,-0.045190997,-1.3860047e-33,0.05034767,0.021843841,-0.016430557,-0.0012268297,0.040195707,0.027628332,-0.13014577,-0.08445163,0.03491104,-0.009807473,-0.0054539414,-0.10373832,-0.0068105347,-0.080030486,0.0027621344,-0.012043981,-0.03881122,0.030299287,0.1070213,-0.012145805,0.0733275,0.0095806,-0.03371534,-0.044173602,0.015640758,0.052193835,0.0066048526,-0.06626624,-0.038350515,-0.032345954,0.0866805,-0.060303424,-0.082706094,-0.07890973,0.09738238,-0.03655786,-0.0011714996,0.0061727613,-0.0814417,0.07096239,0.056976132,0.115015335,-0.009716694,-0.0136663625,0.044886254,-0.023815136,-0.04804687,0.20252247,0.03236548,0.14146768,0.0060985913,-0.06832557,0.044248812,0.03596546,-0.05791606,-0.011313117,-0.03214615,0.009251902,0.07318488,-0.029479133,0.045460455,-0.013523397,0.00039448257,0.05933402,0.03347468,-0.038401503,-0.072501265,0.113771416,0.08578736,0.055729493,-0.097537965,0.036663905,0.024146603,0.037971124,-0.0016061043,-0.0904026,-0.13344672,-0.02802839,0.0878824,0.06976183,0.03338421,-0.04643284,0.013118006,-0.034942433,-0.064793885,0.05908401,-0.05348396,0.020998752,0.012958651,-0.06337767,0.10345563,-0.091501914,5.4157554e-05,-0.0036911468,-0.037635233,-4.6315253e-34,0.03310694,-0.054857206,0.034835685,-0.033734914,0.0051214625,0.021646006,-0.102500334,0.0055081984,-0.002719841,0.014302023,0.0319864,-0.0055018603,0.045099873,-0.06204509,0.004007559,0.015041886,-0.03529001,0.012788288,0.03473286,-0.0340563,-0.021878336,-0.016465632,-0.11103056,0.057769958,0.030393781,0.1008104,-0.036092374,0.040636297,0.038151123,0.087008364,0.07255394,0.04352448,-0.09289763,-0.07102196,0.10573391,-0.0074534374,-0.032446746,0.058320727,0.044543415,-0.014887425,0.04127002,0.07001133,0.029576335,0.09524596,-0.05466427,0.07878739,-0.11499659,-0.011565382,0.05498656,-0.040464014,0.010008821,-0.02762104,-0.11335783,-0.026098588,0.026394349,-0.033506423,0.03588909,0.05012422,-0.020480923,-0.012474766,-0.0738741,-0.07631898,0.023703812,-0.013973926,-0.03553018,0.024486503,-0.03625113,0.08997995,0.052412644,0.0020113655,-0.029606171,0.03540794,0.07690853,0.023641435,-0.057288557,0.007307626,0.008847612,-0.017098302,0.024258869,0.060249873,0.033524178,-0.03364343,-0.059352644,-0.06688607,-0.0012993218,-0.0384048,0.03993878,0.043430492,-0.06436715,-0.087144785,0.0039492487,0.0074147745,-0.018213078,0.005598334,-0.062063735,-2.3226615e-08,0.032769244,-0.079847276,0.050448578,0.048720933,-0.06313303,0.031958546,0.01613547,-0.008951536,-0.00039745602,-0.045646157,0.03611126,0.013918548,0.02234747,-0.0064345556,0.050694417,-0.041628525,-0.041774355,0.0024938611,-0.045351252,-0.040028907,-0.13446356,-0.022340285,-0.08054356,0.020017372,0.040256917,-0.052720997,0.0059679714,-0.028401563,0.08499021,-0.028376186,-0.008146757,0.0011343239,-0.012880277,0.055939734,-0.043630697,0.004059193,-0.00825547,-0.012750697,-0.04025687,-0.02706899,-0.0049245036,-0.0409681,-0.04288083,-0.027113805,0.029433325,-0.009432223,-0.07045053,0.08946199,-0.07251332,-0.020781297,0.04676121,-0.047520548,0.057692975,0.05636185,-0.06161371,0.06838417,0.03141049,0.03554924,0.0025831785,0.01506518,0.0060408036,0.015463182,0.058105733,-0.007826021 +1.13.11.2,Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation.,384,0.99999994,0.04937219,-0.025050439,-0.07707591,-0.021936025,0.09816882,0.012590373,-0.06640639,0.05705253,0.053585943,-0.010212216,0.0025459272,0.025312057,-0.12067309,0.0343011,-0.032519326,0.0030799867,-0.13290043,0.062961124,-0.061820343,0.014734065,0.0820514,-0.0064744996,0.003933515,0.0048820577,-0.10350596,-0.0019231038,-0.021994315,-0.021392835,-0.062374976,-0.052691683,0.051233876,0.0746429,0.019116085,-0.060751837,-0.031719994,0.0636212,-0.024901887,-0.05753306,0.084537126,0.028483875,-0.003270885,-0.06935332,-0.079379484,-0.08240367,0.06775489,-0.059935246,0.013233298,-0.017862879,0.07925383,0.017499007,-0.10377093,0.014799462,-0.018976487,0.029194133,-0.002701205,0.04862577,-0.01419347,-0.032993834,-0.04712037,0.07979692,-0.024096074,0.06887517,-0.038285013,0.054238655,0.06298928,-0.022052523,-0.016480058,-0.01109449,0.09783544,0.024475463,0.033604804,-0.08195,-0.02907868,-0.004459085,0.014817061,0.1298183,0.030151028,-0.021402858,0.09938163,-0.03397134,0.0130189685,0.059667513,0.07679258,0.07364491,0.031925723,0.02076231,0.018539239,-0.0943491,0.037294365,0.09488342,0.07098563,0.0041716155,-0.01241939,0.04764622,-0.008102608,0.040460628,0.005794693,-0.024228787,-0.031323712,-0.025304513,-0.037317477,0.039933544,-0.050333664,-0.033375107,-0.095855415,0.045696512,0.006201106,0.06685824,0.012413459,0.0043436955,0.0432925,-0.01641527,-0.0089420425,-0.07296113,0.030972088,0.1286532,0.0076817106,-0.05789879,-0.03348204,-0.0075417175,-0.045417134,0.006992556,-0.05320682,0.0747565,-0.07523697,0.0025695283,-0.02195369,-2.2294516e-33,0.038776807,0.02074681,-0.043399252,-0.012579946,0.01595983,-0.075658426,-0.044358965,6.7323315e-05,-0.04233789,-0.04592371,-0.02742515,-0.0489721,-0.09226869,-0.0838204,-0.017075228,-0.021088887,0.0002611329,-0.017584428,0.05857249,-0.007927281,0.08384506,0.0063863103,0.028853513,-0.05544413,0.023491038,0.03450996,-0.023651145,-0.0080998065,-0.01096133,-0.008250205,0.04096999,-0.08698958,-0.08376528,0.03744246,-0.0057033426,-0.02296151,-0.017277211,-0.010154217,0.015107991,0.094273455,0.022564648,0.059898835,0.010536996,-0.0022617495,0.08313266,-0.02475886,-0.03506181,0.097577065,0.053941857,0.040895052,0.062098935,-0.031367827,0.04198046,0.04756337,-0.034365702,-0.02763911,-0.05165414,-0.10176869,0.026933817,0.06707204,-0.00090861367,0.025175925,0.002483295,0.10503036,0.042587638,0.011900858,-0.024920385,0.01931034,0.0548442,0.063434,-0.060732245,0.0082633635,0.01639334,-0.03626953,0.04741177,-0.025807863,-0.05734239,-0.025958678,0.025376135,0.056882773,0.020663692,-0.016521338,-0.06818721,0.0630324,-0.048172995,0.035382126,0.023393886,-0.035440143,0.015942054,0.02099724,0.07729043,-0.02273686,-0.022541407,0.033516075,0.02315224,7.857771e-34,0.061224137,-0.09659065,0.038807403,-0.05675842,-0.13602196,0.040717762,-0.0018484809,-0.0499561,0.02398464,0.03198828,-0.013033852,0.0040673874,0.017653493,-0.08703207,-0.06613667,0.0054866667,-0.023814404,0.03468075,-0.0068586674,0.030908553,-0.0043493216,0.103054814,-0.0036707849,0.045102686,0.027779533,-0.0019596266,-0.016620938,0.007831904,0.098309815,-0.009001983,0.11201486,0.005605248,-0.066637956,-0.07164664,0.019962288,0.05784813,-0.045704603,-0.009459227,0.07003356,-0.044164192,0.024660083,0.023228437,-0.009677513,-0.00676927,0.009352947,0.031103171,-0.07778144,-0.0051281857,0.017229328,-0.05155453,0.04244082,-0.028646316,-0.044695847,-0.021803027,-0.0060653556,-0.005474797,0.050255705,-0.04033765,-0.041970454,0.04574582,0.023297912,-0.05175438,0.011411011,-0.049176894,0.010959164,0.110546306,0.05565336,0.12552924,0.03687464,-0.005462251,0.1483427,0.04828073,0.051565815,0.03437147,-0.041168384,0.037039608,-0.03134549,0.022832759,0.003542137,0.00756517,0.02525423,0.014551659,-0.024362762,-0.14919782,-0.015403046,-0.056416705,-0.021763746,0.085159644,-0.02688713,0.06620753,0.0611169,-0.095391795,0.006601572,-0.022938913,0.018046737,-1.9359094e-08,-0.009249954,-0.013504962,-0.015727367,0.0039262753,-0.032154646,0.010016732,0.036780097,-0.047832396,0.047816742,-0.07362645,0.006532012,0.06796817,0.037860155,0.040037002,0.04240475,-0.0142045235,-0.017520292,0.0015271445,0.0021582814,-0.017912805,-0.12320451,-0.0047762566,-0.11962664,-0.052688994,0.01753711,-0.101257354,0.021752717,0.03251924,0.01909855,-0.0099928165,0.052292958,-0.007950171,0.05716606,-0.0063083675,0.0444299,0.022255575,-0.025198564,-0.096654676,-0.04421255,-0.024025131,-0.054798692,-0.04046152,0.019042246,-0.056958973,-0.062026802,-0.043973964,0.047298953,0.044339646,-0.008460049,0.045089252,0.07876433,-0.01747994,0.0013607773,-0.06257529,-0.12783675,0.007115646,0.0041872724,-0.038560335,0.019410444,-0.12175063,0.042371094,-0.075907856,0.09311872,-0.052639667 +1.13.11.75,Contains an Fe2+-4His arrangement. The enzyme is involved in retinal biosynthesis in bacteria [2]. ,384,1.0,0.0066203806,-0.041227482,-0.08048565,0.070896834,0.0887019,0.01109682,0.008125253,0.027969724,0.0013191041,-0.02379934,0.020459281,-0.078302346,-0.047273215,0.0553138,-0.06315184,-0.018135192,-0.09445528,-0.03296609,0.011603942,-0.02516492,0.11369933,-0.009796489,0.013804733,-0.06702524,-0.05356499,0.081460945,0.10145052,-0.05130654,0.014888735,-0.113605276,-0.032028057,-0.02523465,0.059986934,-0.076681495,0.02875442,0.06765006,-0.0016498428,-0.06898989,0.061943132,0.01685539,-0.0062826676,-0.0060461923,-0.007858213,0.009563371,0.03826037,-5.9221475e-05,0.09100758,-0.0071792323,0.026060974,-0.015211062,-0.119721435,-0.019783942,-0.0805815,0.05420947,0.08086389,0.04542524,-0.0618979,-0.025671229,0.0030113563,0.023054833,0.09892743,-0.062660545,0.020555234,0.00014951883,-0.021192234,-0.008039543,0.02648052,-0.07793642,0.03127344,-0.07676317,-0.020432942,0.0029073055,0.029803392,-0.017784389,-0.07154677,0.033509392,0.08309796,-0.05543026,0.09745708,-0.012177236,0.030309238,-0.003134075,0.023110718,0.09217186,0.060043238,0.0409249,-0.0053351084,-0.038609575,-0.027973289,0.052797545,-0.014762479,-0.034458652,-0.0591423,-0.05860001,-0.051231313,0.041823566,0.026030095,0.022689981,0.016295934,-0.02520644,-0.030661786,0.037945557,0.018541671,-0.064508736,-0.03686443,-0.039881732,0.00905187,0.13563564,0.0010345788,0.03253699,0.03794886,0.06457938,-0.0011082643,0.02423971,-0.007951027,0.044694256,0.027280029,-0.057113547,0.013737741,0.02113207,0.057933196,0.028946528,0.06127944,0.043884926,-0.029997721,-0.0053163557,-0.12775633,4.771968e-34,0.03292942,0.052957486,0.0040431893,-0.04313015,0.038082216,-0.026191723,-0.06379496,-0.0011465894,-0.07805177,0.0026626054,-0.092550285,-0.11716423,0.02508066,0.056005042,0.020606255,-0.06504374,-0.035321873,-0.009910085,0.030917645,-0.050910518,-0.05395709,0.123792656,-0.022778373,-0.03398468,0.021789452,0.046416618,-0.024574619,-0.02153925,0.041297782,0.0056333323,0.0730569,-0.013476665,-0.10017367,-0.0043882616,0.11805991,-0.013783295,-0.002411199,-0.049960867,-0.025903238,0.0039162035,0.011898781,0.083622456,0.013020664,-0.050867002,0.061907638,-0.055288818,-0.07063025,0.13250975,0.04880508,0.07478974,0.010483481,0.0030548112,0.07899405,-0.067827895,-0.076647066,0.015846096,-0.030717295,0.070521854,0.04170872,0.04055207,0.031688496,0.04708309,-0.00337424,0.08341961,0.04696093,-0.0062797354,-0.034089558,-0.0056308596,-0.014760012,0.06010082,-0.03501721,0.039893482,0.043528803,-0.0573525,0.012592837,-0.046406,-0.07401609,0.0032137665,0.040093865,0.026340613,-0.042490277,-0.0244876,0.09079186,-0.031076021,-0.05192431,0.042511173,0.006712745,-0.016893495,-0.0072641573,0.004587637,0.06698147,-0.032078873,-0.083316915,-0.0274613,-0.0066728387,-1.8432178e-33,0.018354598,-0.08856173,0.07391667,-0.07026994,-0.11749377,0.03189116,-0.0026452623,-0.019552555,0.017038103,0.00045614183,0.08134597,0.017741272,-0.014676557,-0.08671099,-0.008166032,0.0002015002,-0.0391648,0.06495315,0.035640527,-0.027035238,-0.029844327,0.059210338,0.013732128,-0.03959026,0.07271079,0.057566386,0.0105404565,0.047770917,-0.019914156,0.024746027,0.018610192,-0.020854974,-0.057766147,-0.06773765,-0.05079339,-0.018040452,-0.025836086,-0.036860984,0.033911977,0.02826555,0.027929435,0.0104850335,0.058441024,0.11529022,0.042477068,0.018774388,-0.023393579,0.08331361,0.00710572,-0.016987676,-0.04743714,-0.06461082,-0.097733445,-0.017471004,-0.020198075,-0.0048088185,0.032368757,0.041709,0.0065745604,-0.0057441085,-0.0036135695,-0.12710881,0.08064346,-0.02720802,0.090597466,0.05359054,-0.036021415,0.069089435,0.06923662,-0.04453903,0.15210117,0.0075702025,-0.041982513,0.028057238,-0.03401396,-0.026549635,-0.045222465,0.0010212103,-0.022560725,0.041660774,0.039346565,-0.0028578728,-0.045028303,0.012851084,-0.021989975,-0.074103706,0.06597102,0.09857158,-0.0033031066,-0.038875926,-0.06928887,-0.0012969516,-0.048778944,0.013930494,0.0046711834,-2.5603722e-08,0.027901744,-0.0775722,0.029309832,-0.08409036,0.01186945,0.025704306,-0.016215054,0.028399851,-0.004522432,-0.012777198,-0.03251183,0.089841984,-0.012102066,-0.018265981,0.0662289,0.025407314,-0.021949772,0.027744474,-0.03165628,-0.025301771,-0.0770488,-0.04509736,-0.10486341,0.05090891,-0.017290106,-0.03856304,-0.009671833,-0.012864837,0.01668656,-0.040754907,0.03918032,0.038101792,0.036186628,-0.040973075,-0.1267303,-0.03263416,-0.062223047,-0.0344392,-0.040718336,0.017329631,-0.004947929,-0.031722993,0.0054789926,0.022523727,-0.04627665,0.00018730629,0.019916033,0.005665154,-0.04715485,-0.007986246,-0.014716309,-0.010958481,0.011174141,-0.041712794,-0.16657318,-0.011723435,0.03495566,-0.046881434,0.043559514,-0.0507775,0.036700614,0.050956897,0.15465645,-0.007522013 +1.13.11.3,"Requires Fe3+. The enzyme, which participates in the degradation of aromatic compounds, catalyses the intradiol addition of both oxygen atoms from molecular oxygen, resulting in ortho-cleavage of the aromatic ring. The type of cleavage leads to mineralization via the intermediate 3-oxoadipate.",384,1.0,-0.035258874,-0.0030586699,-0.030508043,0.04963782,0.14457408,-0.039813243,-0.0027492433,-0.061460365,0.015677301,-0.06694514,-0.048121534,0.0026457668,-0.07183521,0.012434032,-0.020876393,0.040568404,-0.07277718,0.04421088,-0.025364505,-0.01964437,0.049949672,-0.026871147,0.00677555,-0.034438487,-0.012455068,0.017689435,0.012634998,-0.049183305,0.026459971,-0.025017958,0.01128128,-0.030875545,0.04416908,-0.07535604,-0.055909097,0.08113015,-0.056464873,-0.042986337,-0.061637275,0.04928697,-0.05728908,-0.03054962,-0.06619476,-0.047380276,-0.008821817,-0.13978595,0.06323273,-0.05339419,0.04019594,0.0016870378,-0.063171536,0.019745227,-0.08747166,0.043523278,-0.029598821,0.005426757,0.0014584466,0.008555716,-0.10728914,0.0015596905,-0.012729846,-0.022628866,-0.022718674,0.039251585,0.069724195,-0.02399724,0.060207013,-0.06599568,-0.041737206,0.0062927087,5.6604596e-05,-0.04817341,-0.047820676,-0.010527824,0.018615482,0.0582441,0.02102874,-0.018588636,0.07903567,-0.020431822,-0.0051212586,0.020295281,0.008771353,0.08558687,0.071550004,0.08236912,-0.060641207,-0.054845944,-0.030844202,0.042023245,-0.01155416,0.03854751,-0.10307946,0.016035121,0.063957095,0.04368009,0.07287553,0.007873558,0.013052571,0.009763007,-0.03579549,0.1077998,-0.031219384,-0.06793724,-0.051110543,0.03157372,-0.025315009,0.108635426,0.0015877347,0.052022863,0.046879373,-0.039183557,0.055779252,-0.027835673,-0.029684935,0.11636977,0.025453132,-0.043338448,-0.05198831,0.016672997,0.041014403,0.018396173,-0.045478962,0.07505456,-0.06350454,-0.01920306,-0.06948105,1.6015234e-33,0.042126086,0.03202968,-0.024151163,0.043339014,-0.090572454,0.054315202,-0.08934513,-0.04074292,-0.059507713,-0.022058591,-0.03096852,-0.04431269,0.023422455,-0.040361226,0.04286932,-0.1031675,0.03608116,0.0040179705,0.055784497,0.006118998,0.04946018,-0.005861572,-0.06390852,0.052674167,0.030608658,0.09448662,0.019185707,-0.016754804,-0.07569808,-0.023295352,0.07399794,-0.065646835,-0.124713354,-0.024990467,0.06448735,-0.008844846,-0.00570068,-0.007845878,-0.046869356,0.027997084,0.0051435237,0.04490954,-0.024866913,-0.016558828,0.058337644,-0.07745502,-0.0057822536,0.2009446,0.033370283,0.07404061,0.024570977,-0.00084312557,0.057879653,0.03377967,-0.10076338,0.010824306,-0.013534871,-0.10791917,0.029775122,-0.002503684,0.039555933,-0.036944054,0.02637088,0.10255541,0.02890358,-0.022914093,-0.026098786,0.07245267,0.026768697,0.102882616,-0.08797278,0.06015243,0.021611521,0.04893703,0.024877753,-0.05156423,-0.07684777,-0.033458967,0.12363541,0.019226614,0.012874679,-0.04886085,0.024774728,-0.0072616027,-0.077128485,0.019442214,-0.029169237,-0.013367431,0.028093725,0.03605195,0.058302782,-0.06452231,-0.024824807,-0.022397155,0.013466303,-3.257101e-33,0.078514464,-0.105370745,0.01730809,-0.07101142,-0.04352213,0.006684003,-0.034474425,-0.084221646,-0.0066072936,0.00552044,-0.0020345594,-0.009464353,0.044360243,-0.1295875,0.0029383397,0.03179361,-0.052422162,0.038222343,0.06588266,-0.012217721,0.012457647,0.06801661,-0.022049688,-0.027301278,0.029778171,0.033366166,-0.10324142,-0.0033438709,0.07367924,0.07801639,8.272525e-05,0.019758336,-0.03437281,-0.01736842,0.004004627,0.09985495,-0.0025373239,0.033494916,0.049515415,0.035958048,0.0044636466,-0.015900472,0.021950468,0.07804823,0.0031188938,0.044125956,-0.04286203,0.053639434,0.006033096,-0.023944095,0.06308931,-0.0035088581,-0.06459997,-0.024845786,0.064999335,0.037725758,0.056210652,-0.028099395,-0.05511738,0.014704113,0.0082101,0.0023863777,0.075173676,0.032357976,-0.030462613,0.05827704,0.007812984,0.12826048,0.017642543,-0.0044019646,0.045135643,0.029989682,0.08038154,-0.009161388,0.007467178,-0.021099938,-0.026526878,0.045207333,-0.030252924,-0.012413093,-0.014224562,0.016489457,-0.01413691,-0.06679943,-0.0045089754,-0.073175475,0.015331691,0.040957503,-0.058464818,-0.048849754,-0.028416589,-0.026190257,-0.04421495,0.030499801,0.016995583,-3.634421e-08,-0.06213037,-0.028316075,0.023013877,-0.05249079,0.014161939,0.0013841095,0.07752629,0.02772369,0.005402698,-0.06476637,-0.013047883,0.073056,0.040236294,-0.040591966,0.09756885,-0.020664036,0.007031286,0.05918307,-0.06143834,-0.07419608,-0.07960993,-0.04425413,-0.10269052,0.017270075,0.036869135,-0.045571983,-0.007411353,0.017304175,0.020917265,0.021397097,0.01547833,0.021222642,-0.01678067,0.010892411,-0.067061365,0.01905385,-0.0028760468,-0.04627475,-0.034230113,-0.04985221,-0.079915404,0.012595759,-0.042071585,-0.024819728,0.023773747,-0.00075210514,-0.059595905,0.014400358,0.006294096,0.018807678,0.046328433,-0.06499068,0.04246422,-0.05597291,-0.056124642,0.040612772,0.04203927,0.025660872,0.05133253,-0.04294661,-0.017163875,0.007332206,0.19488537,-0.090190336 +1.13.11.4,Requires Fe2+.,384,1.0,0.0017429227,-0.0120922215,-0.038558863,0.09142432,0.06785902,-0.058863577,-0.01458679,-0.014261219,-0.07332533,-0.05796829,-0.011215821,-0.015509965,-0.07202684,0.04249708,0.024249421,-0.03321543,0.019945407,-0.020375494,0.030671543,0.04413522,0.05039896,-0.076645784,0.061869685,-0.0806471,-0.07299566,0.021112347,0.025108593,0.011541391,0.031364482,-0.07522699,-0.013137532,0.024824042,0.00782358,-0.025159573,-0.07306664,0.037389968,0.028623296,-0.041204736,-0.07766069,-0.044195645,-0.092444964,-0.051226787,0.004661776,0.019761538,0.016014727,-0.08959922,0.10965217,-0.073083736,0.07675235,0.025391651,-0.047817487,0.012119977,-0.019110482,0.06658772,0.051607575,-0.03403417,0.020699611,-0.032469366,0.0004800927,-0.011221626,-0.017793885,-0.06576893,-0.036475454,0.05335543,0.06464099,0.022822551,0.047862507,-0.07560602,-0.05039111,0.036225423,-0.025612224,0.03532552,-0.052344717,-0.028691012,-0.016723612,0.03522456,0.07033103,-0.055389967,0.12350712,0.0123082185,-0.123151205,-0.03510367,-0.03319499,0.027769485,0.08925549,0.071048334,-0.042034563,-0.054983024,-0.099674575,0.055655226,0.028191065,0.060977615,0.023211394,0.05470533,0.03721542,-0.0003429361,0.0072218375,-0.019805033,-0.08760099,0.06914633,-0.09391643,0.05948289,-0.02463003,0.067270935,-0.015539489,-0.028376048,-0.031077085,0.06590933,-0.0741654,0.0145040555,0.07959369,-0.0071991794,0.03405784,-0.004239101,0.03415664,0.02927697,-0.0066822385,-0.003935083,0.025430325,0.02711847,0.076907285,0.034331284,-0.06844991,0.025891433,-0.060349308,-0.089497626,-0.018967083,-2.074728e-33,0.03875058,0.09118988,-0.0090543805,0.06307697,-0.019233564,0.035965927,-0.06977131,-0.034298696,-0.03491918,0.013025775,-0.051146638,-0.037127115,0.012320491,-0.006813886,0.08286553,-0.12027711,0.062278084,-0.0055497363,0.08970242,-0.0406022,0.06444415,0.01447369,0.01988652,-0.07293302,0.043469448,0.12426544,0.011997116,-0.021612443,0.012783716,0.044091817,0.034164663,-0.05379804,-0.05068308,0.012276918,0.032229804,0.026016157,-0.051090825,-0.02843097,-0.012233348,-0.02187568,-0.010255581,0.07091546,-0.048615243,-0.031659544,0.042125147,-0.101625815,0.0625771,0.08382098,0.008944647,0.108518094,-0.041440237,0.015257649,-0.0135497,0.03280594,-0.008964016,0.0077318638,0.04506646,0.0095773125,0.060724284,0.096419096,0.007831181,0.0152376685,0.09397592,0.07084752,0.008463016,0.0075988555,-0.037691083,0.06428395,-0.022946876,0.04885402,-0.04825891,0.054102004,0.101672865,0.012057786,0.039643303,-0.04500026,-0.039373722,-0.10287057,0.05524383,0.014613132,-0.080241226,-0.04578716,-0.008564254,0.006317822,-0.01804736,-0.030574838,-0.055968333,-0.005918972,0.03520392,-0.021981578,0.021104828,-0.063459106,0.028721329,-0.046397213,-0.032900482,1.9423185e-33,-0.050131872,-0.07233176,0.006517437,-0.009770115,0.0012152584,0.03262746,-0.026354922,-0.17247894,-0.019856434,0.081106424,0.02197408,0.05406422,0.04717696,-0.04765909,0.060986374,0.03714663,-0.064488016,-0.05029234,0.0886715,-0.009229691,0.0075599453,0.08849569,0.027635824,0.04191214,0.039998353,0.05784655,-0.032710597,0.009904373,0.018160459,0.054377098,0.05682356,0.02135305,-0.09520718,-0.037526492,-0.050535947,-0.08163383,0.08369463,0.043726932,0.0040038014,-0.003337331,0.037788805,0.036244527,-0.0042140274,0.14379315,-0.04684554,0.013663093,0.07926568,-0.020665063,0.030223744,0.05057593,-0.018513858,-0.086178035,-0.07583318,-0.03216732,-0.025714448,-0.06935636,0.028185032,0.059341352,-0.026195612,0.029161802,0.062405966,-0.021127302,0.07086086,-0.05336216,0.03923583,-0.052638926,-0.013585774,0.13479158,0.02843234,0.049202528,0.04161349,0.09417971,0.10558358,-0.06084688,-0.021666436,0.0059049153,-0.015171688,0.037239682,0.025117068,-0.019119684,-0.02553583,0.00070164853,0.0087346425,-0.04532933,0.030254306,-0.12709531,0.025486352,0.0056386716,-0.031363763,-0.0065417024,-0.044666093,0.03406188,0.051363,0.020588111,-0.08177112,-1.4773268e-08,-0.07523463,0.0011237485,0.016023146,-0.042561483,0.008760203,0.0085942,0.04015263,-0.031745512,-0.028120264,0.0130028855,0.03657854,0.03740095,0.09984513,-0.0011536697,0.05729272,-0.034588095,0.019776205,0.089067765,-0.07187036,-0.05924737,-0.080893286,-0.041323666,-0.033375647,0.0396294,0.011878222,-0.019456035,-0.0046423576,-0.029919215,0.07149047,0.021430269,-0.058517,0.0038932343,-0.027600368,-0.023435276,-0.02749246,0.027492367,0.0054548956,0.009215663,-0.013423877,-0.050297283,-0.012353761,0.062447686,-0.02013099,-0.022789508,-0.031834174,0.0075663156,-0.07518661,-0.059446964,-0.055041708,-0.0062214406,0.053594608,-0.006450981,0.023155697,-0.008346988,0.014302364,0.09564623,-0.009267767,0.011880439,0.09211617,-0.026712509,0.060796443,-0.03838758,0.041849215,-0.062430806 +1.13.11.5,Requires 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+1.13.11.6,Requires 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+1.13.11.9,Requires Fe2+.,384,1.0,0.0017429227,-0.0120922215,-0.038558863,0.09142432,0.06785902,-0.058863577,-0.01458679,-0.014261219,-0.07332533,-0.05796829,-0.011215821,-0.015509965,-0.07202684,0.04249708,0.024249421,-0.03321543,0.019945407,-0.020375494,0.030671543,0.04413522,0.05039896,-0.076645784,0.061869685,-0.0806471,-0.07299566,0.021112347,0.025108593,0.011541391,0.031364482,-0.07522699,-0.013137532,0.024824042,0.00782358,-0.025159573,-0.07306664,0.037389968,0.028623296,-0.041204736,-0.07766069,-0.044195645,-0.092444964,-0.051226787,0.004661776,0.019761538,0.016014727,-0.08959922,0.10965217,-0.073083736,0.07675235,0.025391651,-0.047817487,0.012119977,-0.019110482,0.06658772,0.051607575,-0.03403417,0.020699611,-0.032469366,0.0004800927,-0.011221626,-0.017793885,-0.06576893,-0.036475454,0.05335543,0.06464099,0.022822551,0.047862507,-0.07560602,-0.05039111,0.036225423,-0.025612224,0.03532552,-0.052344717,-0.028691012,-0.016723612,0.03522456,0.07033103,-0.055389967,0.12350712,0.0123082185,-0.123151205,-0.03510367,-0.03319499,0.027769485,0.08925549,0.071048334,-0.042034563,-0.054983024,-0.099674575,0.055655226,0.028191065,0.060977615,0.023211394,0.05470533,0.03721542,-0.0003429361,0.0072218375,-0.019805033,-0.08760099,0.06914633,-0.09391643,0.05948289,-0.02463003,0.067270935,-0.015539489,-0.028376048,-0.031077085,0.06590933,-0.0741654,0.0145040555,0.07959369,-0.0071991794,0.03405784,-0.004239101,0.03415664,0.02927697,-0.0066822385,-0.003935083,0.025430325,0.02711847,0.076907285,0.034331284,-0.06844991,0.025891433,-0.060349308,-0.089497626,-0.018967083,-2.074728e-33,0.03875058,0.09118988,-0.0090543805,0.06307697,-0.019233564,0.035965927,-0.06977131,-0.034298696,-0.03491918,0.013025775,-0.051146638,-0.037127115,0.012320491,-0.006813886,0.08286553,-0.12027711,0.062278084,-0.0055497363,0.08970242,-0.0406022,0.06444415,0.01447369,0.01988652,-0.07293302,0.043469448,0.12426544,0.011997116,-0.021612443,0.012783716,0.044091817,0.034164663,-0.05379804,-0.05068308,0.012276918,0.032229804,0.026016157,-0.051090825,-0.02843097,-0.012233348,-0.02187568,-0.010255581,0.07091546,-0.048615243,-0.031659544,0.042125147,-0.101625815,0.0625771,0.08382098,0.008944647,0.108518094,-0.041440237,0.015257649,-0.0135497,0.03280594,-0.008964016,0.0077318638,0.04506646,0.0095773125,0.060724284,0.096419096,0.007831181,0.0152376685,0.09397592,0.07084752,0.008463016,0.0075988555,-0.037691083,0.06428395,-0.022946876,0.04885402,-0.04825891,0.054102004,0.101672865,0.012057786,0.039643303,-0.04500026,-0.039373722,-0.10287057,0.05524383,0.014613132,-0.080241226,-0.04578716,-0.008564254,0.006317822,-0.01804736,-0.030574838,-0.055968333,-0.005918972,0.03520392,-0.021981578,0.021104828,-0.063459106,0.028721329,-0.046397213,-0.032900482,1.9423185e-33,-0.050131872,-0.07233176,0.006517437,-0.009770115,0.0012152584,0.03262746,-0.026354922,-0.17247894,-0.019856434,0.081106424,0.02197408,0.05406422,0.04717696,-0.04765909,0.060986374,0.03714663,-0.064488016,-0.05029234,0.0886715,-0.009229691,0.0075599453,0.08849569,0.027635824,0.04191214,0.039998353,0.05784655,-0.032710597,0.009904373,0.018160459,0.054377098,0.05682356,0.02135305,-0.09520718,-0.037526492,-0.050535947,-0.08163383,0.08369463,0.043726932,0.0040038014,-0.003337331,0.037788805,0.036244527,-0.0042140274,0.14379315,-0.04684554,0.013663093,0.07926568,-0.020665063,0.030223744,0.05057593,-0.018513858,-0.086178035,-0.07583318,-0.03216732,-0.025714448,-0.06935636,0.028185032,0.059341352,-0.026195612,0.029161802,0.062405966,-0.021127302,0.07086086,-0.05336216,0.03923583,-0.052638926,-0.013585774,0.13479158,0.02843234,0.049202528,0.04161349,0.09417971,0.10558358,-0.06084688,-0.021666436,0.0059049153,-0.015171688,0.037239682,0.025117068,-0.019119684,-0.02553583,0.00070164853,0.0087346425,-0.04532933,0.030254306,-0.12709531,0.025486352,0.0056386716,-0.031363763,-0.0065417024,-0.044666093,0.03406188,0.051363,0.020588111,-0.08177112,-1.4773268e-08,-0.07523463,0.0011237485,0.016023146,-0.042561483,0.008760203,0.0085942,0.04015263,-0.031745512,-0.028120264,0.0130028855,0.03657854,0.03740095,0.09984513,-0.0011536697,0.05729272,-0.034588095,0.019776205,0.089067765,-0.07187036,-0.05924737,-0.080893286,-0.041323666,-0.033375647,0.0396294,0.011878222,-0.019456035,-0.0046423576,-0.029919215,0.07149047,0.021430269,-0.058517,0.0038932343,-0.027600368,-0.023435276,-0.02749246,0.027492367,0.0054548956,0.009215663,-0.013423877,-0.050297283,-0.012353761,0.062447686,-0.02013099,-0.022789508,-0.031834174,0.0075663156,-0.07518661,-0.059446964,-0.055041708,-0.0062214406,0.053594608,-0.006450981,0.023155697,-0.008346988,0.014302364,0.09564623,-0.009267767,0.011880439,0.09211617,-0.026712509,0.060796443,-0.03838758,0.041849215,-0.062430806 +1.13.11.10,Requires Fe2+.,384,1.0,0.0017429227,-0.0120922215,-0.038558863,0.09142432,0.06785902,-0.058863577,-0.01458679,-0.014261219,-0.07332533,-0.05796829,-0.011215821,-0.015509965,-0.07202684,0.04249708,0.024249421,-0.03321543,0.019945407,-0.020375494,0.030671543,0.04413522,0.05039896,-0.076645784,0.061869685,-0.0806471,-0.07299566,0.021112347,0.025108593,0.011541391,0.031364482,-0.07522699,-0.013137532,0.024824042,0.00782358,-0.025159573,-0.07306664,0.037389968,0.028623296,-0.041204736,-0.07766069,-0.044195645,-0.092444964,-0.051226787,0.004661776,0.019761538,0.016014727,-0.08959922,0.10965217,-0.073083736,0.07675235,0.025391651,-0.047817487,0.012119977,-0.019110482,0.06658772,0.051607575,-0.03403417,0.020699611,-0.032469366,0.0004800927,-0.011221626,-0.017793885,-0.06576893,-0.036475454,0.05335543,0.06464099,0.022822551,0.047862507,-0.07560602,-0.05039111,0.036225423,-0.025612224,0.03532552,-0.052344717,-0.028691012,-0.016723612,0.03522456,0.07033103,-0.055389967,0.12350712,0.0123082185,-0.123151205,-0.03510367,-0.03319499,0.027769485,0.08925549,0.071048334,-0.042034563,-0.054983024,-0.099674575,0.055655226,0.028191065,0.060977615,0.023211394,0.05470533,0.03721542,-0.0003429361,0.0072218375,-0.019805033,-0.08760099,0.06914633,-0.09391643,0.05948289,-0.02463003,0.067270935,-0.015539489,-0.028376048,-0.031077085,0.06590933,-0.0741654,0.0145040555,0.07959369,-0.0071991794,0.03405784,-0.004239101,0.03415664,0.02927697,-0.0066822385,-0.003935083,0.025430325,0.02711847,0.076907285,0.034331284,-0.06844991,0.025891433,-0.060349308,-0.089497626,-0.018967083,-2.074728e-33,0.03875058,0.09118988,-0.0090543805,0.06307697,-0.019233564,0.035965927,-0.06977131,-0.034298696,-0.03491918,0.013025775,-0.051146638,-0.037127115,0.012320491,-0.006813886,0.08286553,-0.12027711,0.062278084,-0.0055497363,0.08970242,-0.0406022,0.06444415,0.01447369,0.01988652,-0.07293302,0.043469448,0.12426544,0.011997116,-0.021612443,0.012783716,0.044091817,0.034164663,-0.05379804,-0.05068308,0.012276918,0.032229804,0.026016157,-0.051090825,-0.02843097,-0.012233348,-0.02187568,-0.010255581,0.07091546,-0.048615243,-0.031659544,0.042125147,-0.101625815,0.0625771,0.08382098,0.008944647,0.108518094,-0.041440237,0.015257649,-0.0135497,0.03280594,-0.008964016,0.0077318638,0.04506646,0.0095773125,0.060724284,0.096419096,0.007831181,0.0152376685,0.09397592,0.07084752,0.008463016,0.0075988555,-0.037691083,0.06428395,-0.022946876,0.04885402,-0.04825891,0.054102004,0.101672865,0.012057786,0.039643303,-0.04500026,-0.039373722,-0.10287057,0.05524383,0.014613132,-0.080241226,-0.04578716,-0.008564254,0.006317822,-0.01804736,-0.030574838,-0.055968333,-0.005918972,0.03520392,-0.021981578,0.021104828,-0.063459106,0.028721329,-0.046397213,-0.032900482,1.9423185e-33,-0.050131872,-0.07233176,0.006517437,-0.009770115,0.0012152584,0.03262746,-0.026354922,-0.17247894,-0.019856434,0.081106424,0.02197408,0.05406422,0.04717696,-0.04765909,0.060986374,0.03714663,-0.064488016,-0.05029234,0.0886715,-0.009229691,0.0075599453,0.08849569,0.027635824,0.04191214,0.039998353,0.05784655,-0.032710597,0.009904373,0.018160459,0.054377098,0.05682356,0.02135305,-0.09520718,-0.037526492,-0.050535947,-0.08163383,0.08369463,0.043726932,0.0040038014,-0.003337331,0.037788805,0.036244527,-0.0042140274,0.14379315,-0.04684554,0.013663093,0.07926568,-0.020665063,0.030223744,0.05057593,-0.018513858,-0.086178035,-0.07583318,-0.03216732,-0.025714448,-0.06935636,0.028185032,0.059341352,-0.026195612,0.029161802,0.062405966,-0.021127302,0.07086086,-0.05336216,0.03923583,-0.052638926,-0.013585774,0.13479158,0.02843234,0.049202528,0.04161349,0.09417971,0.10558358,-0.06084688,-0.021666436,0.0059049153,-0.015171688,0.037239682,0.025117068,-0.019119684,-0.02553583,0.00070164853,0.0087346425,-0.04532933,0.030254306,-0.12709531,0.025486352,0.0056386716,-0.031363763,-0.0065417024,-0.044666093,0.03406188,0.051363,0.020588111,-0.08177112,-1.4773268e-08,-0.07523463,0.0011237485,0.016023146,-0.042561483,0.008760203,0.0085942,0.04015263,-0.031745512,-0.028120264,0.0130028855,0.03657854,0.03740095,0.09984513,-0.0011536697,0.05729272,-0.034588095,0.019776205,0.089067765,-0.07187036,-0.05924737,-0.080893286,-0.041323666,-0.033375647,0.0396294,0.011878222,-0.019456035,-0.0046423576,-0.029919215,0.07149047,0.021430269,-0.058517,0.0038932343,-0.027600368,-0.023435276,-0.02749246,0.027492367,0.0054548956,0.009215663,-0.013423877,-0.050297283,-0.012353761,0.062447686,-0.02013099,-0.022789508,-0.031834174,0.0075663156,-0.07518661,-0.059446964,-0.055041708,-0.0062214406,0.053594608,-0.006450981,0.023155697,-0.008346988,0.014302364,0.09564623,-0.009267767,0.011880439,0.09211617,-0.026712509,0.060796443,-0.03838758,0.041849215,-0.062430806 +1.13.11.11,"A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism [5]. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan [2]. ",384,0.99999994,0.0034100378,-0.022012992,-0.03619096,-0.0715207,0.06374409,0.028071927,-0.05327943,0.01334568,0.023785397,0.08650399,0.05776538,-0.055805143,-0.07353222,0.064888746,-0.006815629,0.046357512,-0.018704262,-0.0634734,0.061675344,-0.048239615,0.0118245715,0.05169023,0.028989,-0.017251298,-0.0068273502,-0.009070056,0.037512757,-0.024862505,-0.016052347,0.003694802,-0.015619779,-0.06664745,0.009236633,0.030025883,0.03580106,0.034489755,-0.06480106,0.098587915,-0.0038241004,-0.010270973,0.003094809,-0.037609432,-0.059433106,-0.021432443,0.017550437,-0.022095082,0.000940134,-0.014781635,0.023842115,-0.0026868267,-0.0011772668,-0.056935973,-0.019757535,0.074113525,0.032576032,0.037784796,0.006049283,0.012911339,0.029558772,0.025755474,-0.030554352,0.047881734,0.0001712674,-0.068018645,0.1302014,-0.07425686,0.0010272234,-0.038057674,0.032822646,-0.03962793,0.0110954875,-0.07351693,-0.010995295,0.023191137,-0.039069638,0.004684268,-0.005423881,-0.04182477,0.02432787,-0.08295917,0.02462792,0.0150562255,0.032379158,0.071093075,-0.0036651033,0.013039815,-0.08261415,0.066888355,0.0018588703,-0.028212266,0.016143685,-0.030617978,-0.06252556,-0.0159855,0.009508958,0.029909007,0.011419363,-0.03947052,0.024552733,-0.038751114,0.035225734,0.032476097,-0.07263083,-0.09302713,-0.06581938,0.015357241,-0.021475272,0.05607839,0.073906094,-0.014619135,0.043073498,-0.020783449,0.075112745,0.0847284,0.01178734,0.046650533,-0.00903371,-0.064718395,-0.04063033,0.04578287,0.0022467265,0.066279575,0.05822295,0.12291855,0.00024431612,0.04808551,-0.023865473,7.1787036e-34,0.12820113,-0.01607559,0.006703658,-0.016882941,-0.060149796,0.039222367,-0.0033215687,0.033739757,-0.010959456,-0.07045176,-0.078449965,-0.12834363,0.05681208,0.0027939873,-0.025815502,-0.014312746,-0.10808621,0.029089019,0.05853286,0.005765096,-0.064849526,-0.044881348,-0.045960702,-0.031171128,0.008709097,0.06089903,-0.045273058,0.02241465,0.0379472,0.022728562,-0.03976494,-0.051163435,-0.10997864,0.045964796,-0.03342289,0.01466425,-0.020457162,-0.0012806534,-0.11651629,0.051038794,-0.0034430807,0.02748403,-0.018408097,0.01319357,0.047426134,-0.010577185,-0.046295002,0.07895466,-0.0013136459,0.025428243,0.024658293,-0.05147071,0.054779388,-0.04484571,-0.0458268,0.009523824,0.004586167,-0.049848255,0.0775807,0.048507854,-0.011369529,0.03906332,-0.08691051,0.084226474,0.0003506167,-0.022497803,-0.076511756,-0.08222952,-0.057892706,0.099192694,-0.033676542,0.030579617,0.095968276,-0.044674035,-0.015577923,-0.029213203,-0.027471859,0.036351126,-0.06063346,-0.036821354,0.039242722,-0.008117284,-0.028637568,-0.033224527,0.004923646,-0.001176729,0.008320442,-0.09466557,-0.0127452295,-0.010333432,0.033743363,-0.06330049,-0.07854593,-0.0039497027,0.02777868,-1.6054562e-33,0.062148187,-0.06548225,0.020643855,-0.058386985,0.00612156,0.054082565,0.025728045,-0.033844072,0.018004192,-0.03404123,0.05689506,-0.06112313,0.06615385,-0.024913535,0.08484119,-0.034194294,-0.04035177,0.14388232,0.0705575,-0.007936466,0.011972872,-0.041890405,-0.057910066,0.007884542,0.038218923,0.019242018,-0.047161486,0.03285822,-0.008026838,0.009337344,-0.030239612,-0.0049570687,-0.089919254,-0.00017433854,0.038587045,0.076946765,-0.13588049,-0.021504356,0.06736908,0.060425017,-0.018772596,0.106655926,0.050724573,0.020021344,0.0056513306,0.08448426,-0.06515886,0.037915736,0.043169014,-0.09019515,0.00086049084,-0.024067892,-0.0054922043,-0.009354084,0.03674049,0.1302239,-0.00853265,0.06985431,0.03223006,-0.04801705,-0.03732989,-0.05770868,0.031293117,0.040000584,-0.008992703,0.07780793,0.04661185,0.11106755,0.012829814,0.016743302,0.018052096,-0.06851287,0.096747614,0.09027159,-0.058141705,-0.090325676,0.01947274,0.033594295,0.07427352,-0.006651577,0.0555615,0.06553078,0.030538077,-0.04553839,0.026749607,-0.050229166,-0.04644163,0.118755616,0.04905826,-0.012400026,-0.028195705,-0.030821042,-0.055949703,-0.037974928,0.082489386,-4.1776076e-08,0.058512747,-0.10434986,0.02395554,-0.016076278,0.0045284345,0.042013824,0.093969904,0.044706263,0.057242557,-0.031008512,0.05968731,0.030029375,-0.022204703,-0.012865928,0.044098184,0.028878503,-0.013506457,0.00014468492,-0.038333252,-0.01550661,-0.110896945,-0.010687468,-0.051585402,-0.026882675,-0.045447327,-0.0047982275,0.0008945578,0.06970346,0.0070336647,-0.03435073,-0.05808961,0.02543582,-0.02093535,-0.046830267,-0.03000787,0.034657408,-0.043587394,0.054676164,-0.005070127,-0.023663156,-0.023656972,-0.10037421,-0.033661842,-0.036875583,0.044429928,-0.038758114,0.028301807,0.007651141,-0.021825392,-0.0133687835,-0.07598718,-0.051492874,0.033654243,-0.03361343,-0.070900805,0.0010305913,-0.059347406,-0.13246949,-0.059032988,-0.104625925,0.07716353,0.11860924,0.13867699,0.025450042 +1.13.11.12,"Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids.",384,1.0,-0.06370078,-0.07382945,-0.08398384,0.037317414,0.1410688,0.15498655,-0.08692351,-0.011525919,0.008607312,-0.06579397,0.047780868,-0.04270334,-0.082276106,-0.08892809,0.016116915,-0.020962743,-0.04347568,0.03882592,-0.01242848,-0.030942304,0.03723734,0.016542066,0.056860708,-0.021645905,0.034957025,-0.003302196,0.033258323,-0.05433574,-0.03459475,-0.08174806,-0.012700265,-0.0022567848,0.07247508,-0.012659025,-0.038161714,0.009176031,0.020488493,-0.10513459,0.027478658,0.034129974,-0.023308726,-0.037510462,0.012317547,-0.05105206,-0.00030758858,-0.025565358,-0.008940832,-0.030451877,-0.0070795617,-0.0037133233,-0.018302614,-0.09226678,-0.021889443,-0.0022203769,-0.0066414126,-0.0068958495,0.05365972,0.018849593,-0.033795785,0.055470485,0.058109164,-0.0071387086,0.018173227,0.06648688,-0.030790458,-0.04817565,0.01859174,-0.043205664,0.049844913,-0.08961792,-0.055161275,-0.045040168,-0.059578273,0.015850605,-0.1163789,0.08544413,-0.052749116,-0.05097232,0.054062888,-0.012501373,0.009586381,0.004677056,-0.061825313,0.07737187,0.037717905,0.007071965,-0.03458847,0.027298475,-0.023680834,0.06862613,0.030250773,0.03518504,0.032218162,0.06505708,-0.072127506,0.079399005,0.12724143,-0.029848674,-0.020304505,-0.01987738,-0.03175826,0.08746371,-0.004585911,-0.033060517,-0.04984708,0.012623929,-0.10357222,-0.055356245,-0.039989803,0.017057758,-0.02443932,-0.03743959,0.011067497,0.03594506,-8.848562e-05,-0.001491891,0.12065849,-0.09300825,-0.065383464,0.015698198,0.014770729,-0.09491073,0.021995151,0.044114344,-0.040563807,0.013823962,-0.059856202,2.8933695e-33,0.11423191,-0.017058741,-0.04909131,0.0050564297,-0.061499614,-0.00319551,-0.09826838,0.04302211,-0.028636787,0.019997532,-0.067989565,0.006998119,0.03030678,-0.0073347427,-0.031647626,-0.0070153857,0.015016507,0.020443952,0.13115391,-0.0073915683,-0.03921031,0.08647974,-0.02101826,-0.028096367,-1.0259957e-05,0.012017388,0.019599218,-0.05641998,-0.01227038,-0.026284156,0.046394084,-0.06486732,-0.02445752,0.061174925,0.047706157,-0.03166927,-0.015348529,-0.045791995,-0.018562553,0.046543088,0.034997508,0.03911967,0.08071093,-0.05124903,0.07504927,-0.027488908,-0.07511526,0.08928173,0.10340315,0.058219902,-0.0030938857,0.06322259,0.08177826,0.06770193,0.037576146,0.0031307214,-0.021415649,0.030573579,-0.01017042,0.07032446,-0.009726214,0.043321796,-0.022987554,-0.01920407,0.03002376,-0.039706074,-0.13402988,-0.0034578592,-0.028635427,0.09203992,0.08696223,-0.02369351,0.053541683,0.043231957,0.05241904,0.01043224,-0.04143235,0.050138246,0.006775508,-0.020797426,0.06922411,0.025503889,-0.0010852057,-0.0038253923,-0.07349393,0.05582565,-0.07074219,0.03457917,0.0042685606,1.8400902e-05,0.038389213,-0.013514434,-0.03295065,-0.025648255,-0.004931217,-2.7464243e-33,0.071314536,-0.033230618,-0.0139708705,-0.07242409,-0.017539356,0.05908272,-0.011655236,-0.11221188,0.030007476,0.030959828,0.05180308,-0.024442658,0.08616687,-0.0955272,0.046461698,0.0033681262,0.011309004,0.07124445,-0.03846476,0.0028350381,0.032928053,-0.013602087,-0.038542658,0.03528528,0.060756277,0.0033888011,-0.06364287,0.027095074,-0.041013494,0.07425969,0.060716562,-0.039563775,-0.0449632,-0.06317442,-0.0026566288,-0.035273936,-0.06138927,0.04775059,-0.010280922,0.038481474,-0.04592828,0.017242188,0.057020117,-0.021181516,0.0638272,-0.035508864,-0.114375345,-0.04566545,0.06469513,0.016021626,-0.023819294,-0.02517021,-0.011986123,0.050384134,0.054095358,0.05474417,-0.018734992,0.051294357,-0.016728995,-0.07091891,0.043015134,-0.02085988,0.0226165,-0.03727505,-0.04125248,0.057668354,-0.02608327,0.00036083895,-0.02367587,0.021333963,0.0066584838,0.007856092,0.04524947,0.022827456,-0.03068928,-0.056930102,0.06836684,-0.037386023,-0.03616982,0.017715499,0.06739069,0.033305086,0.0099318195,-0.09035524,-0.020475172,-0.0114531005,-0.0033199482,0.011244674,0.08293695,0.016434478,-0.04202085,0.017251847,-0.074528195,-0.0021430806,0.07397605,-3.9098587e-08,-0.04520029,-0.083234526,0.058859635,-0.023718785,-0.04114616,-0.042085003,0.01986164,-0.045177676,0.034172945,-0.09377748,0.014650807,0.13666812,0.03771449,0.042413373,0.096850574,-0.030276947,0.053455688,0.04577018,-0.041895315,-0.011547285,-0.055170234,0.002317976,-0.03231645,-0.008118968,0.006685118,-0.048240025,-0.013531173,-0.014397431,0.11536817,0.069271006,0.0068184542,0.020071799,0.074020535,-0.10627519,-0.04024076,0.032487277,0.058851887,-0.031653527,-0.062235396,0.07404356,-0.015420938,-0.050981063,-0.073736735,0.018444331,0.05874386,-0.022456802,-0.013662937,0.040360715,0.006675097,0.072299026,0.014213539,-0.026183313,-0.006308412,-0.024615223,-0.046731472,-0.01862046,0.019634932,-0.04170394,0.0041911197,-0.0053408374,-0.023563648,-0.009749027,0.21884705,0.0008142834 +1.13.11.13,Requires iron(II).,384,0.99999994,0.0014523091,0.027252575,0.017929079,0.14652438,0.028499665,-0.07374985,0.044689853,-0.024867844,-0.044972967,-0.038950577,-0.007944057,-0.00930845,-0.039508447,0.042648185,0.023895964,-0.070207894,0.03478252,-0.044564117,-0.05675341,0.057358988,0.053185023,0.002313728,0.03796027,-0.029366715,-0.058299087,0.016295183,0.011448823,0.0595313,0.018484415,0.008140258,-0.005221072,-0.012147138,-0.06039624,-0.0028405336,-0.026067061,0.017309526,0.010601276,-0.036861863,-0.068499915,-0.018606562,-0.015039532,-0.11111492,0.019859834,0.019101424,0.014097741,-0.007364287,0.06008752,-0.012114141,0.015921555,0.049425174,-0.08074685,0.039302077,-0.015895054,0.05718556,-0.01385979,-0.0039961915,0.0108495,-0.029758504,-0.011128948,0.025854643,0.010918698,-0.07108024,-0.08090309,0.047503352,0.10147377,-0.028184576,0.054938894,-0.046469588,-0.06838021,0.039978802,0.007083465,0.03556207,-0.1379736,0.027731998,0.005539074,0.029246073,0.043913156,-0.05515014,0.08982839,0.027445488,-0.14043196,-0.0005275654,0.019506758,0.064473405,0.046654392,0.08633993,-0.0042501125,-0.041572694,-0.13786075,0.049790043,0.020294946,-0.019988356,0.015585006,0.051941156,0.06503691,0.010421412,-0.019767003,0.03375018,-0.10854892,0.033853635,-0.10367238,-0.0016567648,-0.053759914,0.051686544,-0.026726527,0.004622056,-0.044103406,0.00036654237,-0.003591875,0.023541052,0.022569235,-0.023933593,0.06838805,0.013870685,-0.008313731,0.049025256,0.07875068,0.016993912,0.0029642237,0.07624696,0.057215378,0.025888538,-0.009263245,0.015902126,-0.031328,-0.1355765,0.045060225,-6.394196e-33,0.016387064,0.03079215,0.05699989,0.04036546,-0.03762866,0.032003846,-0.12474885,-0.05322417,-0.010901688,0.019643623,-0.05535641,-0.011823006,0.013934648,0.0032307259,0.030237451,-0.063035145,0.11116909,-0.030703938,0.10299545,-0.042499516,0.06523321,0.029667115,0.06524572,-0.040416297,-0.03883727,0.07817232,0.048914894,-0.039703257,-0.029419739,0.04507585,0.044800516,-0.05833638,-0.01895969,-0.007811858,-0.0021943513,0.030469207,0.0016875152,-0.015753223,-0.046503153,-0.005475343,0.02135818,0.013856562,-0.014957764,0.01568572,0.10248507,-0.08834165,0.024694674,0.08417159,-0.02417116,0.07292593,0.0019015038,0.07003174,0.066555604,0.01728124,-0.0053855865,-0.024484891,0.025828423,-0.020529104,-0.0012035227,0.09663611,-0.009050834,0.042365696,0.053211834,0.14183725,-0.027597858,0.041049987,-0.06468994,0.060408056,-0.06501275,-0.012520816,-0.051135127,0.030415002,0.11675433,-0.01949768,-0.024545105,-0.0445555,-0.04547554,-0.03685935,0.038575336,-0.05949756,-0.052883167,-0.039195567,-0.029194878,0.016007364,-0.053043757,-0.029280432,-0.04170247,-0.0020592988,0.0845642,-0.065231234,0.006199312,-0.06046538,-0.0007473051,-0.09139075,-0.022749193,4.1639478e-33,0.00020910175,-0.0326671,-0.023898734,0.020729234,0.007994924,0.025245592,-0.014203039,-0.12578931,-0.035318017,0.045799673,0.07128179,-0.0391464,-0.011500358,-0.04711551,0.058107965,0.07241081,-0.044044692,0.05679117,0.038529664,-0.015383889,-0.022884656,0.08613345,0.057248645,0.06922727,-0.023207957,0.034127202,-0.0544015,-0.02746851,-0.017834343,0.07187955,0.017325997,-0.018496169,-0.08158515,-0.081566975,-0.060472548,-0.04690105,0.034349613,0.024487723,-0.038509686,0.0021187137,0.02820191,0.008290703,0.08784376,0.15234081,-0.03183167,-0.011680772,0.045052778,-0.013639911,-0.005673024,0.052165724,0.012678911,-0.10627482,-0.061664876,0.0071892412,-0.0053000827,-0.043398965,0.00017878384,0.038774624,-0.05023905,0.039956044,0.016429596,-0.0033799533,0.045510158,-0.01624218,0.043761186,-0.052542154,-0.032375436,0.09545709,0.08185468,0.031858724,0.01547778,0.07070013,0.092564225,-0.11593673,0.009264118,0.031142784,0.03909415,0.06736096,-0.032055814,-0.023993446,-0.09234198,-0.05039753,-0.026554387,-0.007218034,0.03772231,-0.1298595,0.003445029,-0.097242415,-0.020879513,-0.014344707,-0.07040379,-0.01950206,0.067094915,0.039922353,-0.010760454,-1.5617143e-08,-0.04493823,0.002795271,0.019648628,-0.05302319,0.0060290247,0.01207727,0.018367697,-0.020780537,-0.007784412,0.020311713,0.0011957579,0.08678758,0.11951801,0.025286961,0.065014906,0.019497944,0.022639645,0.058934376,-0.062303692,-0.0683609,-0.07021503,-0.07294208,0.019333972,0.048217777,-0.011219556,0.003934842,-0.024722993,-0.06129205,0.041724075,0.07906756,-0.0078302035,0.0070402822,-0.018332656,-0.03150886,-0.10910299,-0.027190175,0.027429353,0.04108503,-0.027549312,-0.02304325,-0.081277505,0.014852986,-0.07297852,0.04405214,0.02521566,-0.030940091,-0.06745954,0.02891074,-0.041366845,-0.0005734273,0.03461176,0.01498418,0.059721977,0.058256824,0.005071149,0.11200412,0.00538853,0.0029015644,0.035510294,-0.01081553,0.063558385,-0.0015410167,0.04271254,-0.08328148 +1.13.11.15,An iron protein.,384,1.0,-0.030547986,-0.03268735,-0.05595656,0.15550317,0.0442354,-0.007506916,0.1622413,0.058103777,0.016559854,-0.058792975,0.0030690578,-0.008893409,-0.075591646,0.017419748,-0.03966154,-0.052111983,0.04198234,-0.025664162,-0.058964368,0.0068538054,0.0027510147,0.04255883,0.006320065,-0.002107357,-0.08329024,0.03714809,0.048363067,-0.026688123,-0.05226514,-0.030014912,-0.020868955,-0.051098548,0.01299584,-0.013005335,0.010010474,0.03439715,0.019343158,-0.08804186,-0.03796503,-0.02848354,0.025082355,-0.04318314,0.011232076,-0.04563005,-0.03692763,0.01863868,0.060054123,0.045620862,0.08031214,0.10587497,-0.06848729,-0.08225148,-0.04627238,0.015060828,0.0038270317,-0.02178657,-0.012633058,-0.05860608,-0.07301761,0.024823286,0.009839735,-0.034348264,-0.036547344,0.0227835,0.1067995,-0.063182995,0.032347493,-0.016381796,0.017907739,-0.0378191,0.044491664,0.037264176,-0.07401127,0.055130348,0.01575915,0.011436892,0.024796715,-0.05587558,0.13305157,0.04799229,-0.046305284,0.029927505,0.012773555,0.08654123,0.05077902,0.040816944,0.035724293,-0.022354916,-0.09736554,0.03525654,-0.02456924,0.02693569,0.0061639952,0.0027245763,-0.0010393744,0.03241702,-0.02799546,-0.011196223,-0.060391255,0.073171824,-0.052279893,0.056657,0.026916659,-0.043743324,-0.01301581,-0.028008236,-0.075971425,0.102866225,0.056486934,0.029414296,0.011236396,-0.003523678,0.031656995,-0.011495763,0.021672964,0.041508224,0.082971364,-0.013394809,-0.052017406,0.05855747,0.044709805,0.042282853,0.00992665,0.061418083,-0.05460479,-0.033508003,-0.055620875,-6.0478332e-33,0.009801702,0.03302355,0.07308017,0.0717402,-0.045413457,0.035399396,-0.08529944,-0.03877216,0.019198408,0.0415423,-0.07346607,-0.035902135,0.053019505,0.019096645,-0.0100326445,-0.10571655,0.0004975177,0.004095414,0.07439895,-0.0051826136,-0.016483264,0.12595978,0.10053588,-0.02218163,-0.009802621,0.003900434,-0.06510544,-0.05278599,-0.066217005,0.020871667,-0.010348511,-0.042238563,-0.061026324,-0.05690128,0.052044537,-0.074288905,0.024347046,-0.09515657,-0.07290331,0.019256324,0.08184817,0.0010281787,-0.04921878,-0.008955797,0.041778803,-0.051745225,-0.02345346,0.062103525,-0.0760717,-0.020936474,0.042986065,0.017649999,0.09250152,-0.034169383,-0.09938647,-0.01682665,-0.005256022,0.026783396,0.0135540115,0.08293358,0.03538349,0.04738584,-0.02766189,0.110920444,-0.0063020573,-0.037647624,-0.061067116,0.0071319146,0.032809302,0.069814816,-0.02330907,0.024190528,0.11841261,-0.056769732,-0.044209834,-0.059741467,-0.10412704,-0.018279396,0.03801016,0.042277716,-0.021437796,-0.037039172,-0.018398965,0.010685505,-0.09204458,0.065621614,-0.015064733,-0.0075299703,0.08099413,-0.079396814,0.0037960778,-0.030279603,-0.026987076,-0.060794983,-0.036137894,3.25156e-33,-0.00015605334,-0.07774647,-0.017012445,0.08494499,0.035413973,-0.017252456,0.010733522,0.00010921009,-0.0657,0.053086944,0.13044572,-0.09169637,0.048356853,-0.0667507,0.07963411,0.14878677,-0.076970205,0.04065113,0.09508405,0.026172925,-0.09290007,0.00073548703,0.0716238,0.046538822,-0.01800282,0.060221285,-0.03058381,-0.05653826,0.006511485,0.075865515,-0.028235255,-0.031092253,-0.0037305208,-0.13466857,-0.06996982,-0.0032241652,0.057824895,-0.04966594,0.0364994,-0.018577367,0.046073556,0.0005558244,0.05080373,0.13955006,0.026521984,0.0026292552,-0.039472908,0.009942361,-0.012719961,0.04213727,0.050094794,-0.066648014,-0.02863319,-0.0040481933,-0.02979368,-0.023425626,-0.025050394,0.04482483,-0.027972117,0.115378596,-0.021861667,-0.019194547,0.07146641,0.065466635,0.038437363,0.032645747,-0.03750081,0.0140900165,-0.031438697,0.0074316496,0.0998737,0.047383063,0.06459466,-0.029312909,0.054895923,0.002885127,0.016903544,0.038604148,-0.048839252,0.049689915,-0.11545964,-0.045598958,-0.017762046,-0.0047896784,0.050341357,-0.06856544,-0.0003149344,0.009648166,-0.03239399,-0.022178855,-0.06619679,-0.06597968,-0.05316923,0.01973258,0.0031741718,-1.2778442e-08,0.010725331,-0.04179835,-0.029455876,-0.067830175,-0.005872341,0.020825097,0.001838066,-0.085639216,-0.013044954,0.022963153,-0.012202513,0.10366144,-0.0036974312,0.024328334,0.017121114,0.0022789757,-0.020842846,0.052050963,-0.022122433,-0.011968845,0.008456651,0.022542236,0.067895524,0.0015558144,-0.03595551,-0.06570697,-0.04500874,0.015109252,0.024354307,-0.006388884,-0.03331594,0.055960137,-0.026549146,0.010442001,-0.06346821,-0.004715345,-0.008321135,0.0033110196,-0.07312384,0.009063667,-0.06763877,0.017750904,-0.06699612,-0.026215198,0.008498962,-0.027425637,-0.048921864,0.039026536,-0.03191648,0.021714957,0.04802261,0.018943755,0.065556645,0.023598526,-0.0036381017,0.038427502,0.007216478,-0.08516541,0.00024349778,0.009282982,-0.024277324,-0.059714332,0.042911,-0.0397725 +1.13.11.16,An iron protein. This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.,384,1.0,-0.005540469,-0.032920774,-0.062136773,0.10420163,0.15368561,0.028123936,0.029571354,0.011577116,0.013810237,-0.060438436,0.01997999,0.04051112,-0.0504367,-0.008862731,-0.05610697,0.0040255776,-0.09443552,0.0563603,-0.05196963,-0.0019463763,0.027315062,-0.010042076,0.006012023,-0.016804297,-0.019680636,-0.01074083,0.09229603,-0.032967784,-0.0312763,-0.0030978406,0.03756885,-0.008352688,0.036087077,-0.040140208,0.0072732735,0.041206416,-0.008832028,-0.09486616,-0.015325895,-0.0073565496,0.0054994067,-0.013184308,-0.028364979,-0.0956252,-0.0363286,-0.017902913,0.012775755,0.020393128,0.036897678,0.036233578,-0.06153224,-0.037400212,-0.01860771,0.015223658,-0.02721138,-0.0035164857,-0.009095454,-0.044478953,-0.0464493,0.060901396,0.008408684,-0.055234484,-0.054064304,-0.027774919,-0.018435137,-0.019320825,0.044095777,-0.017896011,0.029019747,0.005013996,-0.05133321,-0.037322786,-0.08949296,0.009319755,0.031293243,0.051680215,0.019779734,-0.073471844,0.084203325,-0.06852772,-0.0034867958,0.02779172,0.06551324,0.02838977,0.06976167,0.035326485,0.021707667,-0.05845662,0.034719605,0.06748022,-0.020408012,0.05374562,0.04182204,0.031791154,-0.011070517,0.06757209,0.030828202,0.024849007,-0.017908817,0.049362004,-0.03913079,0.0542666,-0.01225352,-0.086310185,-0.028793504,0.0437766,-0.03607247,0.127103,0.014289711,0.0011406362,0.041904133,-0.0212744,0.06335639,-0.044980083,0.05405487,0.050554685,0.05879272,-0.017162938,-0.07027308,0.027653443,0.01972329,0.06648881,0.02060873,0.06294029,-0.07516849,0.005089446,-0.07403717,-9.2280375e-34,0.034891818,0.039756857,-0.0118691195,0.04952853,-0.045085654,-0.022665793,-0.11185447,0.0044184662,0.006268501,-0.05147102,-0.05031816,-0.10308025,0.023810018,-0.06754193,0.02009028,-0.092234835,0.032880463,0.04786248,0.1171221,0.008094716,-0.004672039,0.06898373,0.003863572,-0.039067168,0.033818234,0.06335179,-0.036967758,0.016041324,-0.09262694,-0.005881117,0.021758711,-0.08732294,-0.15455633,-0.0064032,0.038723692,-0.055686533,0.012506902,-0.06639213,-0.07064976,0.038333233,0.002926326,-0.02064066,-0.046670496,0.009728961,0.051555734,-0.06507185,-0.002773332,0.10909747,-0.029109754,0.059562992,-0.031723704,0.03821391,0.09889488,0.02834054,-0.13823655,0.023827368,-0.0034089475,-0.04206771,0.050606098,0.056668602,0.049096387,0.08774084,-0.013058379,0.071741045,0.035820257,0.005735253,-0.05184354,0.008297428,0.010734575,0.087435074,-0.016945587,0.014355541,0.10088575,0.0079211425,0.053629383,-0.08565955,-0.14166044,-0.03556535,0.027172862,0.04870473,-0.051958006,-0.033089038,-0.045003515,0.015639948,-0.09521892,0.07413596,-0.019059215,-0.054037023,0.04075104,-0.08952017,0.044128865,-0.06601521,-0.027714293,0.004019294,-0.006502391,-5.7855495e-34,0.049566966,-0.046527874,-0.037798993,-0.006630353,-0.06758657,-0.030727359,-0.010492298,-0.008613586,-0.099207535,0.0032359285,0.0872979,-0.10773296,0.0046740663,-0.10442444,0.035908002,0.10253644,-0.008806379,0.013728851,0.0670717,0.0029308086,-0.055980653,0.05088603,0.003052283,0.055446014,-0.008912746,0.0031363235,-0.008206403,-0.026891178,0.09021082,0.09978417,-0.007752968,0.031077394,-0.019233312,-0.083541915,-0.0012024818,0.03395888,-0.019774215,-0.055031613,0.054254916,-0.0032403662,0.054446906,-0.00048496775,0.024549542,0.09407006,0.060731802,0.068127,-0.075242415,0.079358585,-0.007570052,-0.02851423,0.047156755,0.05279437,-0.0210708,-0.015060085,-0.016166022,0.026828606,0.05568528,0.04537047,-0.05645369,0.07852975,-0.045667674,-0.06307776,0.09053163,0.09172693,0.05223884,0.066762835,-0.04086451,0.11632928,0.033777073,-0.033594638,0.08778697,0.047104347,0.08358425,0.004740629,0.0056582657,-0.037540894,0.012913574,0.02562728,-0.05129842,0.03872463,0.00012234875,-0.0945302,0.018494314,-0.069011,-0.019429026,-0.11706165,-0.036469378,-0.0063918894,-0.03538957,0.01360988,-0.018939268,-0.10951815,-0.06656028,0.03906687,-0.028222112,-2.1960489e-08,-0.011171887,-0.027369518,0.029952563,-0.07789422,0.020802224,-0.012246117,-0.0029617425,-0.006190558,0.00043720036,0.01437293,-0.046156254,0.07862882,-0.012258188,0.01437703,0.001712065,0.039927326,-0.02445983,0.04610882,-0.00548296,-0.00077622867,-0.06804215,0.011218107,-0.04964233,0.021008475,0.0070872046,-0.061023924,0.045610502,0.02689302,0.044389553,-0.051558454,-0.034726672,0.032208465,-0.011029575,0.029606251,-0.001515604,0.023988321,-0.025790649,-0.051893465,-0.05236237,0.06919146,-0.07931057,0.033595875,-0.08054321,-0.019424943,0.033414077,0.030255351,0.011626326,0.036107484,0.0043996274,-0.02583789,0.054426968,0.01338016,0.0046299743,-0.012750936,-0.058540348,0.03321308,0.027261626,-0.062376946,0.03802513,-0.020684188,-0.05267255,0.01534601,0.11911551,-0.095139086 +1.13.11.17,"Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (2,1-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product.",384,1.0,-0.083833754,-0.04165667,-0.14571792,0.0023802489,0.14746368,-0.012161562,0.009519941,0.029468605,0.022562545,-0.029041126,0.07300619,-0.023550594,-0.015647437,0.003989992,-0.09523095,0.0012028468,-0.010167658,0.023165056,-0.038751893,-0.06559187,-0.00032378963,0.01176588,0.0017975785,-0.029289633,-0.044276416,0.010556702,-0.035526138,-0.0009572146,0.002665398,-0.0510472,0.0017068636,0.060556572,-0.04248452,-0.027387677,-0.024613377,0.017879564,-0.060910016,-0.07504618,-0.0075351633,-0.01899158,0.030818304,0.041187447,0.01650015,-0.042703237,-0.006212817,-0.0048059816,0.002753035,0.009116768,0.01583469,0.045258753,-0.063201025,-0.029646972,-0.10465931,0.07807244,-0.018325252,-0.02307528,0.03303538,-0.051131524,-0.08420649,0.038945485,0.05860774,-0.05779075,0.014121291,-0.011465463,0.0036586963,-0.024210654,-0.020836627,0.04615435,0.058959212,-0.08832615,-0.057187725,0.028688814,-0.06333303,0.09941702,-0.06309079,0.14948271,0.08618048,-0.017657619,0.060896203,0.008046317,-0.023696832,0.057199858,0.038003024,0.037320983,0.037026145,0.027984656,-0.059076678,0.04492228,0.08923855,0.049422536,0.1235441,0.059378225,0.0058617597,0.0036389288,-0.051916853,-0.0050398437,0.036969796,-0.046944287,-0.051822867,-0.05789075,-0.045653217,-0.0012291035,0.056941293,-0.089767694,-0.11998855,0.013215472,-0.081510685,0.036925968,0.06966148,0.0028210462,-0.0052159135,-0.04679039,0.06403024,-0.04787358,0.0025663946,0.019389864,0.043885928,-0.046090025,-0.029915107,0.046143994,-0.017824784,0.030600464,0.034060255,0.056052495,0.041465987,0.015029992,-0.12031838,5.0632472e-33,0.060163777,0.074429706,-0.03764039,0.0430751,0.03481937,0.056168288,-0.015275279,0.0010380663,-0.02909318,-0.030351121,-0.10540872,-0.041511,0.025772061,-0.052111927,-0.014066271,-0.019549107,0.011842183,-0.06560854,0.004754466,0.020724865,0.009925554,0.13452043,-0.05978153,-0.0009767791,0.055737182,0.038993303,-0.013375082,-0.0062507526,0.0075967545,0.01922302,-0.005364276,-0.069186635,-0.08867222,0.04213465,0.10499849,0.0551136,0.015799671,-0.033161,-0.02343003,0.04517631,0.0033619266,0.024367208,0.009971419,0.03514083,-0.0015282794,-0.058898948,-0.11759861,0.13174729,0.0734369,0.010210165,0.022029977,-0.011825994,0.08745809,0.009067804,-0.08583699,0.06994597,-0.06689833,0.008717509,0.035168976,-0.010348799,-0.043532398,0.024179535,-0.06631298,0.07046426,-0.046291944,-0.023824122,-0.07411155,-0.056347907,0.021893704,0.12085091,-0.019988611,0.0009823645,0.08545867,0.0396911,0.07149367,-0.04298541,0.015841037,-0.06881814,0.012933822,0.06964722,-0.0209773,-0.013847674,0.012228818,-0.035753783,-0.06592318,-0.030433884,-0.057098955,0.012199305,0.01214422,-0.009767726,0.046917517,-0.025184756,-0.04466546,0.0018909646,-0.044595398,-4.9631583e-33,0.03864701,-0.026893692,0.023158487,-0.015291217,-0.015056472,-0.030944437,-0.025478328,-0.035468202,-0.00020374877,-0.033979446,0.0807095,-0.055214167,-0.01770903,0.013046937,0.02826052,-0.018341616,0.033539057,0.124524675,0.03823212,-0.023929885,-0.09658529,0.004304528,0.032820426,-0.045639824,0.0047407905,0.011003795,-0.03718875,-0.008838899,0.025954204,0.04218425,-0.033272248,-0.01777268,-0.063025035,-0.0075715617,-0.050721485,0.0405181,-0.016145015,-0.018287174,0.0758134,0.029747507,0.0547487,0.0020260175,0.06405814,0.070528425,-0.032894798,0.025293605,-0.05736005,0.04102943,0.035547215,0.0017012763,0.016890474,0.0102754105,-0.042160623,0.054319687,0.050548557,0.012116864,0.0793273,-0.0066842083,-0.10677017,0.015892688,0.03189226,-0.09110017,0.0051604267,-0.04396381,0.04731096,0.107199304,0.059206422,0.07155395,0.07623741,-0.049130764,0.08959262,0.06113217,0.053828843,0.023891862,0.013707762,-0.036833398,-0.044566236,0.035457127,-0.0104964925,-0.10927696,-0.003404265,0.020405442,0.029307256,-0.040653884,-0.009463862,-0.06149914,-0.02590403,0.121715285,0.07183808,-0.00022618656,-0.036185138,-0.03016829,0.03310147,0.06403453,0.071095444,-4.310409e-08,-0.02693267,-0.10631505,0.0038849774,-0.063867174,-0.059966553,0.053240996,0.005459719,-0.010724953,0.04402345,-0.017236149,0.035430335,0.14838,-0.09350025,0.023285873,0.022763487,0.017202169,-0.03220552,-0.033164475,0.005700965,-0.01319639,-0.047192294,-0.0054757427,-0.079230055,0.033326324,-0.049087938,-0.043573707,0.0054146713,0.033668146,0.034259386,0.0010386965,-0.057249676,-0.023673374,-0.004259645,-0.018683461,-0.1343661,-0.02915862,0.0018169056,-0.010813567,-0.02749853,0.0024857742,-0.024553481,-0.016255923,-0.029619578,0.0005478216,-0.0087226285,-0.109082215,0.01513996,0.008608026,0.070561655,-0.06300049,-0.015003178,0.021202927,-0.0033847243,-0.03931765,-0.042089216,5.520735e-05,0.050184406,-0.019576853,-0.002076427,-0.07031678,-0.04738873,-0.005327725,0.16310145,0.0013865063 +1.13.11.18,"An iron protein. Perthiols, formed spontaneously by interactions between thiols and elemental sulfur or sulfide, are the only acceptable substrate to the enzyme. The sulfite that is formed by the enzyme can be further converted into sulfate, thiosulfate or S-sulfoglutathione (GSSO3-) non-enzymically [2].",384,1.0,0.0063208127,-0.054021254,-0.060685918,0.07914643,0.0632983,0.0141093945,-0.0060911537,0.027516834,-0.030528054,-0.0014328917,-0.0051234122,-0.035807576,-0.04567073,0.019889675,-0.030119427,0.009419802,-0.01175694,0.006983156,0.033123262,0.021821294,0.060362868,-0.018289346,-0.07096501,-0.017718572,0.0014091508,0.027970962,0.06611181,0.014318718,-0.05116118,-0.009837821,-0.06552358,-0.10647482,0.02444515,-0.030074473,0.0031278364,0.059688255,-0.003728405,-0.039845526,-0.037060753,-0.030622082,0.0048102005,-0.01391249,-0.002768831,-0.02387111,-0.03451946,-0.08192537,0.023044772,0.011402419,-0.0028134384,0.088285424,-0.06460468,-0.11303882,-0.037593577,0.046970982,-0.022054367,-0.0128062535,-0.06084683,-0.031491682,-0.035002954,-0.0482563,0.03119412,-0.024503121,-0.04313195,-0.068223745,0.07967779,0.02849222,0.004100261,0.008110817,0.030490454,-0.0059194556,-0.018819131,0.0046046786,-0.08433699,0.04663581,0.008501289,0.12453358,0.0015517774,-0.035930563,0.09707291,0.008080066,-0.015733398,0.0503203,0.0075517152,0.09043382,0.06919177,0.013157896,-0.0022667227,0.00018231256,-0.03755565,-0.0034959558,0.0073573925,0.015515765,-0.0152091095,-0.028353509,-0.039873876,0.022438092,0.0010638785,0.08178429,0.0041102828,-0.008610986,-0.039436553,0.038410872,-0.030380448,-0.07746961,-0.027397614,0.020127816,-0.1500421,0.09282703,-0.0151895415,-0.009575891,0.013771878,0.016959112,0.02416042,0.023017125,0.04690452,0.12431305,0.085552454,-0.053464446,-0.13308266,0.03978482,0.05421051,0.09520663,0.0290606,0.054584324,0.019082483,-0.026287183,-0.08836644,1.3241308e-33,0.06880736,0.0608712,0.035402693,-0.0153584,-0.044604257,-0.069406,-0.07166657,0.037477396,0.0061182184,0.06868597,-0.090977035,-0.01874799,0.077010825,-0.06858061,0.046668984,-0.06270107,0.05495984,-0.003947846,0.10380538,-4.4138797e-05,-0.046320315,0.084960245,0.017419953,-0.07923357,-0.014917494,0.019866657,-0.005589622,-0.060550477,0.018773668,0.020385811,0.029742477,-0.11942598,-0.0510542,0.00715259,0.057966072,-0.033469647,-0.0011369821,-0.020677157,-0.03347032,0.0026086273,0.080402836,-0.0017739665,0.017335182,-0.039221704,0.038085025,-0.11152911,-0.08032416,0.05105235,-0.015845472,0.033632684,0.03844679,-0.016461365,0.10293807,0.022413949,-0.061439876,0.004715182,0.010441287,0.013185525,-0.003550271,0.08333899,0.078522846,0.0058218534,-0.0046436545,0.0197863,-0.019402506,-0.010840269,-0.038645502,0.019024484,-0.02127957,0.09531501,-0.025699519,0.03936712,0.014149291,0.011837131,-0.06502167,-0.059658058,-0.032384735,0.03232094,0.03649491,0.019219149,-0.022567995,-0.009655353,-0.106402785,-0.012722636,-0.10125673,0.013036102,0.024218203,-0.018638821,0.007951501,-0.04294834,-0.034493256,-0.025805788,-0.066748045,-0.022531051,-0.027003584,-3.126787e-33,0.064560324,-0.10179075,0.030785043,-0.030973991,-0.07863654,0.07193785,0.07767905,-0.0033526374,0.021296091,0.05439455,0.08029162,0.0121201025,0.02488569,-0.09038119,0.05149046,0.06978571,-0.0454526,0.026302308,0.061835054,-0.04907288,-0.056837153,0.10420989,0.039729767,0.03285474,0.014121611,-0.00857145,-0.04169069,0.04336941,0.05026811,0.11973941,-0.02090908,0.028881552,0.03076167,-0.14799997,-0.10351924,0.02754053,0.0391222,0.026942844,0.08443301,0.039525528,0.004332088,0.015693104,0.03798418,0.16823533,0.02742251,0.055777095,-0.043081194,0.0075615477,0.018586276,0.012906429,0.06424767,-0.07781775,-0.03970402,0.03228194,-0.025288789,0.038313795,-0.035652976,0.011303513,-0.085058995,-0.00302397,-0.08353717,-0.037056305,-0.012030113,-0.057876807,0.034786236,0.0725592,-0.09087895,-0.01887616,-0.018757826,-0.011369991,0.051313676,0.024401456,0.010410623,-0.021948908,0.052008294,-0.048509665,-0.04733507,0.055471204,-0.04816924,-0.005819446,-0.017286794,0.08573045,0.0308655,-0.0021549244,0.07532652,-0.106118105,-0.007725958,0.099932395,-0.0038275872,-0.031598903,-0.05987536,-0.044963144,-0.050004043,0.04639051,0.022501092,-3.850095e-08,-0.038722362,-0.022350073,0.008202258,0.0015683663,-0.05041171,0.07001218,0.031349093,-0.047122512,0.010350213,0.019391358,-0.070020944,0.086389855,-0.059647284,-0.025756389,-0.017549902,0.004206732,0.0010552558,0.05908723,-0.031268835,-0.045024075,-0.053831905,0.025070922,0.00084473845,0.022472586,0.016827999,-0.028940678,-0.006984827,-0.12535514,-0.023573896,0.022198701,-0.00245225,0.040365394,-0.014443084,0.0020341352,-0.0856702,-0.009086721,-0.057326857,0.01580591,-0.026700554,0.0021292192,-0.05056318,0.044814255,-0.12747538,0.016531777,0.018778017,-0.010860552,-0.009906728,0.060378984,-0.005352087,0.011278699,0.033755552,-0.02249052,0.032881804,-0.08313089,-0.058439735,0.062130913,0.029892167,-0.0752663,-0.009126869,0.019246345,0.040415667,-0.055067025,0.15387192,-0.04158542 +1.13.11.19,"A non-heme iron protein that is involved in the biosynthesis of taurine. 3-Aminopropanethiol (homocysteamine) and 2-sulfanylethan-1-ol (2-mercaptoethanol) can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3].",384,1.0,0.030117847,-0.05202908,-0.03741731,0.00375683,0.09803988,0.046855282,0.041942246,0.045200348,0.022914723,-0.066429965,-0.023371123,-0.029657854,-0.019783493,0.014187221,-0.0052313562,0.030902158,-0.0082158595,-0.0136611825,0.030638227,0.0025548972,-0.010000577,-0.028329857,-0.006892843,0.017080622,-0.032240808,-0.01303772,0.04025971,-0.009551195,-0.040770162,0.018735541,-0.047288716,-0.096498415,0.01759656,-0.051287472,-0.009737862,0.023512935,-0.07109112,-0.018851427,-0.038614944,-0.012040334,0.09361094,0.023681968,-0.039937083,-0.05068713,-0.004156191,-0.046588633,0.063505076,-0.04007822,-0.018058648,0.047412544,-0.049319465,-0.012992376,-0.02340912,0.07088857,0.03643698,0.09521501,-0.049943242,-0.12272985,-0.02798797,-0.0017814537,-0.040787358,-0.013822845,-0.11279144,-0.09572077,0.047332555,-0.010495349,0.02239521,0.050117135,0.0286368,-0.0028713068,0.0015205605,-0.0054679746,-0.054554235,0.038733717,0.00030947127,0.060519163,-0.052516382,-0.025282076,0.05688011,-0.08026338,-0.0150870485,-0.03321679,0.020980475,0.08350242,0.13543268,0.02559951,-0.013556318,-0.023792313,-0.009977724,0.021934861,-0.02263594,0.1046599,-0.030166391,-0.072691575,0.0028344335,0.029026158,0.04824774,0.052135866,-0.03362746,0.034758423,-0.030898193,0.040119715,-0.024512503,-0.059065297,-0.043500792,-0.03087948,-0.025724944,0.07420123,-0.012429184,-0.019758645,-0.0056710276,-0.033992846,0.0041446616,0.012869632,0.058944665,0.100186296,0.07547631,-0.08296785,-0.052121073,0.014803702,0.01432026,0.053771827,0.07769955,0.027774507,-0.038068563,0.03019056,-0.023841875,3.2846706e-33,0.041646708,0.09394057,0.035736915,0.017773222,0.0015217826,0.022647005,-0.11545017,-0.08621273,0.05338792,-0.005646267,-0.01670828,-0.07158709,0.00991376,0.008351314,0.0736618,-0.09688708,0.021312755,0.03103856,0.12889712,-0.0017562468,-0.031293027,0.12009926,-0.033937417,-0.040004272,-0.008017547,0.017990721,-0.090701975,-0.030067787,-0.056552548,0.031324815,-0.025292972,0.080951214,-0.049459547,-0.026516957,0.060344126,-0.036649257,-0.086122535,-0.08925717,-0.025419526,0.04163997,0.06559739,-0.01774356,0.015497393,0.017947221,-0.0051386654,-0.017152961,0.017861841,-0.007841042,-0.019404035,0.057557784,-0.0031016376,-0.0037700264,0.101905465,-0.099907406,-0.07797083,-0.030683063,-0.007109794,-0.08352109,0.046736646,0.10796004,-0.018501973,0.07206075,-0.0052970448,0.033758484,0.03565573,-0.028644009,-0.063315116,-0.03327143,-0.03887093,0.084534876,0.026825815,-0.042600565,0.029616594,0.043526065,0.0389763,-0.0029369525,-0.124112494,0.04549689,0.0015728333,-0.05942385,-0.02473088,-0.033850066,-0.07423154,-0.008490697,-0.043899875,0.020984096,0.05686176,-0.030436385,0.074517675,0.0023399815,0.034456424,0.0032401686,-0.06507284,0.018403322,-0.070757106,-3.4504455e-33,-0.0030957405,-0.10816601,-0.027401777,-0.056735277,-0.055632513,0.09781894,0.009197928,-0.03712039,0.023105934,0.022295017,0.14639162,-0.025189072,-0.05411835,-0.040718682,0.015755843,0.032942638,0.01521352,0.04668461,0.07460275,-0.041451614,0.025062386,-0.012419115,-0.031376686,0.1121978,0.066124104,0.017477846,0.012782129,0.010883173,0.12960586,0.049715567,-0.02606258,0.048071638,0.039376806,-0.10062356,0.03243764,0.014894495,0.09214434,0.034865398,0.025448414,-0.04642936,0.030417634,0.022429757,0.058229037,0.10973981,0.030248543,0.034515362,-0.062223457,0.004829405,-0.0384949,-0.003926958,0.027291413,-0.107889846,0.013739978,-0.048980445,-0.012831361,-0.022622054,0.041787658,-0.06482137,0.018557169,0.004877845,-0.014524737,0.049540028,-0.05006075,-0.025413487,0.07360855,-0.011320843,-0.05894334,-0.0049229236,-0.040034283,0.05241038,0.082180254,-0.020016663,0.071903184,0.024190951,-0.013139861,-0.00730582,0.005583883,0.03628568,-0.019208215,-0.01313138,0.024921674,-0.0059966184,0.013241419,-0.038485844,-0.049712136,-0.07839816,0.025476143,0.08755187,-0.012339157,-0.0032899706,-0.03937892,-0.030825067,-0.03778891,0.12003966,-0.0072935894,-4.288521e-08,0.019890534,-0.078503475,0.02056798,-0.040627792,-0.11284938,0.030922733,0.07175288,-0.051485024,0.065370575,0.005733108,-0.056426037,0.11228491,0.064402245,-0.0164029,-0.034916494,0.07722082,-0.011386487,0.039368805,-0.012735892,-0.030597404,-0.03935372,0.07056105,-0.019640263,-0.039235204,-0.010815813,-0.07834621,0.004041811,0.019598326,-0.012040035,-0.07995827,0.0560081,-0.022415165,-0.031096356,-0.0059624407,-0.033228427,0.00913843,-0.016868047,-0.10685001,0.01606016,-0.024798846,-0.03103742,0.04469193,-0.074364536,0.004782512,0.08883305,-0.026894666,-0.0028232713,-0.0107607525,-0.007130108,-0.007220623,-0.0066037276,0.013515258,0.052546922,-0.09634652,-0.074686535,-0.005198788,0.018316489,-0.08968269,0.020738648,-0.06296826,0.020080293,-0.0090743555,0.17319342,0.017213937 +1.13.11.20,Requires Fe2+ and NAD(P)H.,384,0.99999994,-0.0439441,0.03070985,-0.048670072,0.07099415,0.030092519,0.05052779,-0.029900618,0.017894993,-0.031684835,0.0063584107,0.008011545,-0.012499623,-0.09042995,0.044123087,-0.0053201155,-0.013248634,-0.05191687,-0.0025953741,0.04499736,0.04741759,0.060344618,-0.051213022,0.09267106,-0.058365338,-0.06368404,0.051349547,0.043572087,0.043970667,0.04170436,-0.10368713,-0.03649469,0.018890511,-0.012438766,-0.03900028,-0.018759608,0.07152029,-0.06350647,-0.016576156,-0.07547217,0.01156233,-0.00972515,-0.07108741,-0.014510573,0.038602162,0.016407365,-0.072186984,0.10590169,0.0040341276,0.05640865,-0.01227169,-0.0488301,0.00851025,-0.01312908,0.010483463,0.021094117,-0.024166802,0.033652585,-0.021261735,-0.00809157,-0.07543597,-0.039442595,-0.05186011,-0.07584925,0.027082223,0.10109863,-0.0080147805,0.08167734,-0.04556273,-0.06343592,0.04817096,-0.05626117,0.01888411,-0.050572183,-0.043312147,-0.0026732497,0.042723358,0.013191409,-0.082268305,0.12772104,0.020868147,-0.035740007,-0.0045157545,-0.06707525,0.031696208,0.11060918,0.058220644,-0.06511875,-0.02246,-0.10005454,-0.009677029,-0.012593149,0.020688113,-0.049278624,0.06337865,-0.06127897,0.02502848,0.08873276,-0.0035606988,0.0025760764,-0.0055599776,-0.036100563,0.106334455,-0.05017414,0.012892817,-0.077606834,0.031500246,-0.034115482,0.10920403,-0.028264891,0.051315404,0.0033582323,-0.0055453344,0.03583806,-0.020534135,0.010801607,0.04391751,0.025616804,-0.009721779,-0.04292256,-0.0037196141,0.038962428,0.023477709,-0.003922572,0.052297894,-0.029819671,-0.07730463,-0.08866727,-1.4239094e-33,0.087104626,0.060466994,0.017443594,0.05586364,-0.046439845,0.04620693,-0.09946482,-0.041241683,-0.037004814,-0.0069668563,-0.07142934,-0.115059204,0.047908854,-0.05355997,0.0007523076,-0.020730626,0.01478333,-0.026566075,0.01157998,-0.0008516582,0.055982333,0.0816248,-0.0018185909,-0.027498726,0.01502803,0.06899846,0.019603644,-0.009599346,-0.018552214,0.010340695,0.054537304,-0.06600047,-0.051690556,-0.0011723175,0.015397886,0.0067288787,-0.078606054,0.0088972,0.0064574196,-0.03818136,-0.04715891,0.064148724,0.016320275,-0.05717758,0.05761124,-0.12862206,0.07130598,0.10313782,0.011578871,0.10227085,0.01610465,-0.010514039,0.04302692,0.0072586527,0.007790436,0.025908414,0.003238471,0.03546317,0.0035972453,0.119088314,0.04194857,0.03471803,0.019079555,0.086028606,-0.030462183,0.031443138,-0.09922744,-0.0077120764,0.034288146,0.043715205,-0.014980264,0.065786876,0.09680523,0.0036653865,0.04687295,-0.026489584,-0.017654575,-0.07624988,0.08252783,0.036702275,-0.011750887,-0.04193807,-0.0076224706,-0.023964282,-0.05220781,-0.044345856,-0.013401867,-0.020184485,-0.022631701,0.030585306,0.050681736,-0.07266347,0.06393907,-0.115508445,0.04035702,-3.316648e-34,0.02594407,-0.0025603154,0.036251973,-0.084077746,-0.016312107,0.04155503,0.042347055,-0.1792649,-0.024328243,-0.00016972046,0.03302855,0.014002811,0.013110232,-0.094626516,0.024773508,0.02154565,-0.070534475,0.0046962183,0.038215626,0.021241605,0.012235192,0.13476609,-0.0029933737,0.019421855,0.03724557,-0.007751094,-0.036085576,0.0015232034,0.04271679,0.079917625,0.004687236,-0.0010377895,-0.10299942,-0.017571356,-0.003600793,-0.024379726,-0.0014335666,0.043883547,-0.0035908392,0.056429427,0.01395906,-0.013457225,0.0067803604,0.05458933,0.005006909,0.039778635,0.0030585013,-0.057542656,0.039206937,0.025051156,-0.0055978997,-0.041901503,-0.10257304,-0.036046334,0.04795032,-0.0018276224,-0.020555308,0.06542525,0.026956849,0.013020492,-0.009095201,-0.024694059,0.06959903,-0.037447903,0.018991405,-0.028443245,-0.03557203,0.090596154,0.072814114,0.0026842265,0.027877571,0.10542448,0.09152833,-0.026530737,0.029990535,-0.03393083,-0.024014967,0.047254805,0.0025883804,-0.033450603,-0.042654987,0.025811909,-0.034132782,-0.06601978,-0.0057870233,-0.12269225,0.03793519,-0.03736713,-0.020320982,-0.016928798,0.019198662,0.06684597,0.07832131,0.03585429,-0.03425578,-1.8414973e-08,-0.024610203,-0.021734856,0.0415306,-0.062154215,0.03229671,0.018813934,0.041724,-0.06813317,0.0062374435,0.022459636,0.039176706,0.091257535,0.103165284,-0.020110328,0.07546468,-0.06685229,-0.04463394,0.050860528,-0.067873456,-0.08852235,-0.102991946,-0.040619195,-0.11234708,0.08364256,0.01780301,-0.045415785,-0.017776093,-0.100621,0.067908645,-0.050452415,0.021914752,-0.0090050185,0.032414805,-0.027465852,-0.029933691,0.015038005,0.022507446,0.029635303,-0.04916548,0.007511116,-0.006313641,-0.013776806,-0.022616485,0.02087244,0.02981189,0.047745485,-0.0783801,0.0025209582,-0.061826788,0.02057575,0.030651119,-0.010245206,-0.0045768525,-0.07503165,-0.01737006,0.08021853,-0.019057078,0.0018399695,0.07618441,-0.1269888,0.09590198,0.0059663258,0.05248552,-0.036916807 +1.13.11.24,"The enzyme from Aspergillus sp. is a copper protein whereas that from Bacillus subtilis contains iron. Quercetin is a flavonol (5,7,3',4'-tetrahydroxyflavonol).",384,0.99999994,-0.089208975,-0.09079633,-0.10311482,0.091492474,0.04689574,-0.0151176,-0.00034745087,0.06321068,0.04906747,-0.14629632,-0.0026101987,-0.06891318,-0.036663182,0.0040486385,-0.12826072,-0.06677679,0.05791381,-0.003172822,-0.022455024,-0.06921954,0.032622382,0.027087945,0.045776833,-0.00080880313,0.040810473,-0.0070739132,-0.013718742,-0.040619053,-0.06161512,-0.026523596,-0.02973366,-0.02393857,-0.025884854,0.006849156,-0.0039204266,0.0045207716,-0.0336482,0.000178783,0.036684476,-0.0126590375,-0.0103045525,0.0027511236,-0.0038254063,-0.008165726,0.011361122,-0.027119627,-0.014601431,0.03467522,0.039273195,0.054914292,-0.09351603,0.0061668656,-0.058367115,0.029556543,0.03481808,-0.0036485028,-0.021153852,-0.048672635,-0.020677919,0.02741724,0.016869778,-0.007829529,0.0011371684,0.0107750455,-0.029216776,-0.01813168,0.031117639,-0.016363025,0.0076520564,-0.07202023,-0.050660193,0.004881942,-0.02112241,0.026158212,0.043346584,0.15302272,0.024912432,-0.040336564,-0.014153119,-0.010169589,0.04128508,0.03560782,-0.011047872,0.102587044,0.03297525,-0.029728875,0.033826258,-0.008016113,-0.007392575,0.053325105,0.10148131,0.13329992,-0.021446913,-0.057472374,-0.032075807,0.05646624,0.000627403,0.032088574,-0.026634185,-0.023645608,0.015921133,-0.046883605,0.05359047,-0.019644141,-0.02137382,0.006033087,0.07146585,0.01585543,0.1477799,-0.017088534,0.03113591,-0.04383181,-0.0052571837,-0.11521075,0.056670297,0.014816563,0.037127722,0.035399627,-0.061268423,-0.03321819,-0.012706162,0.1323444,0.021960294,-0.04309664,0.030195778,-0.017358089,-0.068262696,2.6647711e-33,0.05953969,0.03602308,0.012501706,-0.030476462,0.02618484,-0.014576879,-0.02651947,0.07393009,-0.026366897,0.00298425,-0.06592926,-0.08073193,-0.052180447,0.03478295,0.037905168,0.03164824,0.010016791,-0.06766836,0.029577974,0.008538163,0.06279681,0.075153925,-0.05600243,0.07571767,0.06476981,-0.05986359,0.0010518905,0.057511352,-0.056750804,-0.038240228,-0.017528128,-0.073057435,0.00033639546,-0.03073936,0.048207264,-0.00903202,0.06495164,-0.012488764,-0.033836264,0.0029165056,0.0072222226,-0.004185111,0.033414777,-0.029636335,-0.009547708,-0.08251805,-0.11594727,0.06276231,0.0013570717,-0.02151358,0.060967654,0.008947463,0.123503976,0.027433833,0.0063937875,0.060023542,0.0072552245,0.09937215,0.06544879,0.051196974,-0.01773706,0.008712568,0.003579241,0.03604627,-0.020001084,0.056396008,-0.047167573,0.0069998866,0.0773416,0.027685884,-0.025992276,0.04837701,0.047894098,0.0021433264,0.05978409,-0.027523713,-0.12761663,-0.027928852,0.014972494,0.07819043,-0.07050033,-0.04937774,-0.027059747,0.013580297,-0.18109429,0.029964002,0.042918168,0.055959426,0.08396026,-0.033786383,-0.009891822,-0.10760314,-0.04055142,-0.01507805,0.036441498,-2.3787928e-33,0.08610481,-0.07612598,0.06731723,0.013932314,-0.06346196,-0.00933539,0.02264236,-0.031945147,-0.025568081,-0.029799042,0.07831908,0.0023608156,0.044744715,-0.04022854,0.016272675,0.08995249,-0.051019922,0.07890534,0.070580475,0.025182744,-0.10192596,0.051815033,-0.010515346,-0.037730575,0.07817685,0.028026376,0.015155387,0.010518609,0.025487565,0.009495944,-0.0390536,0.0238116,0.03592315,-0.06886118,-0.090767294,0.05024616,0.032468915,-0.038963463,-0.014700938,-0.0216987,0.0397588,-0.022261534,0.027639294,0.12656352,0.036148507,0.038796797,-0.035798516,-0.037039433,0.003139226,0.021529272,0.051080402,0.04249766,-0.011464564,-0.0005582462,0.023704322,-0.027118202,0.0117257405,0.016487114,0.0016055728,-0.038693797,-0.05360251,-0.037373204,0.009698075,-0.0027912648,0.054662827,0.104754955,-0.044037543,0.033299703,0.076849736,-0.14065932,0.04785904,-0.027423363,0.0827552,0.062110886,-0.006991172,-0.022420064,0.033712056,0.111828476,0.0010775664,0.042289328,-0.0074612726,-0.07578235,-0.030812254,-0.03392634,-0.056568194,-0.00096599746,0.022715833,0.072987296,-0.037472606,-0.009748338,-0.0729941,-0.060468715,0.0092369635,0.0027891616,0.06688212,-3.4279424e-08,0.021912808,-0.0120137045,0.022855546,-0.014708171,0.030519992,0.027712928,0.008996354,-0.0144708855,-0.04589118,0.025970193,-0.074750334,0.06753586,-0.077975616,0.051548485,-0.004255431,0.007200646,-0.027237643,-0.021234477,0.04667592,-0.053312678,-0.0705386,0.01693591,-0.12808289,0.0027943917,-0.07739073,-0.02734965,-0.01678949,0.018187966,0.013498252,-0.029795611,-0.04945169,0.010592322,0.0122125475,-0.04044192,-0.06980642,-0.04399949,-0.031970143,-0.036167063,0.018050259,0.03782426,-0.02908651,-0.021719828,-0.05956443,-0.05117216,-0.06955781,-0.094006255,0.0031354488,0.09604353,0.042877663,-0.031800892,0.033688232,-0.018076688,0.019213803,-0.07207947,0.012690657,0.04754264,0.10002105,-0.007759601,-0.06846982,0.012813282,-0.029561179,-0.09600744,0.119005166,-0.015663458 +1.13.11.25,Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.,384,1.0,-0.023982683,-0.073989175,-0.039164435,0.0519209,0.07479169,0.003600176,-0.02402649,-0.018930664,0.014790857,-0.05639484,0.036299445,-0.03563265,-0.104767546,0.08117984,0.020059759,0.018638898,-0.028743677,0.031712517,0.020072633,-0.01772668,0.034494244,-0.034503985,0.064664006,-0.029254423,-0.095956355,0.03565715,0.01719455,0.016956154,0.024808023,-0.113936484,-0.041696385,-0.013640343,0.009524445,-0.0744185,0.008532101,0.055135712,-0.06716496,0.002117834,-0.01893121,0.007468814,0.01582584,-0.0953206,-0.036639165,-0.0011097569,-0.04830363,-0.12233092,0.032372262,-0.040140633,0.0506022,0.033277858,-0.06860653,0.033873033,-0.031503044,0.05051321,-0.004751541,-0.033267394,0.018641755,0.025698578,-0.033977166,-0.020607518,-0.042648297,-0.0014905813,-0.08731924,0.020810219,0.019029154,0.05932073,0.00901938,-0.04557292,0.0033516295,0.037364237,-0.02647744,-0.0490471,-0.02302981,0.051942587,-0.010902295,0.0264151,0.0817516,-0.07075855,0.09578584,-0.022545157,-0.10285487,-0.02421323,0.032927863,0.049213104,0.094161116,0.0055719535,-0.10196271,-0.031978246,-0.07432281,0.08308472,0.030757908,0.02236699,-0.019603437,0.009980394,0.041969135,0.05428473,0.0041552754,-0.018292805,-0.05152662,0.016168388,-0.07736393,0.03022941,-0.06904563,-0.002940045,-0.0022406203,-0.037524,-0.032950066,-0.010918438,-0.036368005,-0.010051408,0.009283604,-0.058688864,0.068324834,0.026162341,-0.03404099,0.047208387,0.023446351,-0.036817104,0.015943008,-0.061182197,0.046367157,0.01374269,-0.010171406,0.02657781,-0.120290615,-0.01992035,-0.0048943306,2.2668172e-33,0.08237808,0.0741743,-0.024076575,0.10566292,-0.0512441,0.06311118,-0.087153025,-0.0221295,-0.018932732,-0.018547963,-0.016676143,-0.116201356,0.017971672,0.013383246,-0.0057838745,-0.07193187,-0.01143534,0.014070269,0.0782962,-0.06407845,0.023854183,0.122451,-0.01774097,-0.056129985,-0.006384985,0.0788655,-0.022617085,-0.00020341121,0.04053308,0.016159775,0.042713277,-0.021650001,-0.061167248,0.002055339,0.043270845,0.100855164,-0.04041942,-0.03427294,-0.028557729,0.03532647,0.062004454,0.06726852,-0.04242452,-0.059769575,0.081585325,-0.06737194,-0.03309745,0.12690333,0.0029317557,0.11574077,0.028698048,-0.006639585,0.031053869,0.01949045,-0.061642013,0.0054312497,-0.0056764605,-0.021114495,0.042856585,0.04370206,0.0031873328,0.019034674,0.08286056,0.031342383,0.0704754,-0.021634456,-0.08213604,0.040262975,-0.020638632,0.05943734,-0.027843053,0.04568868,0.1092786,0.0361556,0.065386124,-0.04262251,-0.10298738,-0.03884632,0.086535655,0.0219265,-0.029477183,-0.074287936,0.027910791,-0.013955666,-0.052472405,0.020036627,-0.033450674,0.0009349041,-0.0011739586,0.0008327752,0.07660876,-0.043266904,0.0036680826,0.0395117,0.03659587,-3.774927e-33,0.0019825087,-0.08609897,0.08260306,-0.05194448,-0.040915914,0.009075524,-0.0020374262,-0.13629675,-0.00096046354,0.03235723,0.09592641,-0.04544768,0.011140365,-0.07341016,-0.0028346314,0.06615517,-0.07508782,0.0002624895,0.03909857,0.008245057,0.013843763,0.09463777,-0.050759077,0.18734357,0.055800527,0.039394464,0.00090365065,-0.012121952,0.04852883,0.079502515,0.00074562046,0.021485668,-0.0774961,-0.11843998,0.0039017226,0.026613075,0.0042501823,0.011227005,-0.045663293,-0.031163761,0.00234725,0.02774131,-0.006314374,0.082164995,0.0022787943,0.043300953,0.03911092,-0.022096077,-0.021922523,0.025236754,-0.0023025204,-0.08530307,-0.064770184,-8.605005e-05,-0.0026596116,0.010255775,0.052906245,-0.006375535,-0.02790486,0.0013230796,-0.025820073,-0.0053111743,0.06324335,-0.104013085,0.054360017,0.005543785,-0.009973054,0.10272207,0.084290236,-0.01653239,0.052635167,0.057648927,0.11001119,-0.03218815,-0.009576105,-0.058736347,-0.0011246111,0.004300102,-0.023944078,-0.00799336,0.0072749658,-0.022328354,-0.014850005,-0.0243569,-0.017718004,-0.083131954,0.032864723,0.034361653,-0.044582147,0.036248054,-0.036920607,0.036672376,0.024316141,0.05604352,0.0013929065,-3.4650114e-08,-0.013873312,-0.041326825,0.008566357,-0.0817226,-0.039123572,0.009099794,0.010334887,-0.040715456,-0.021346465,-0.040570468,0.02208356,0.08861733,0.05170187,0.048774302,0.039419595,-0.059854817,-0.033143148,0.106540024,-0.035573903,-0.11279852,-0.15568525,-0.03200345,-0.060827408,0.011928158,0.016510693,-0.019040648,0.012360451,0.0069996193,0.08019747,0.0072680376,0.0088753505,-0.0020028125,-0.06285332,-0.004210996,-0.02619388,0.08537822,0.02638889,-0.0709695,-0.03722086,0.04513918,-0.021100221,0.047902368,-0.028915793,0.012623592,-0.0042260215,-0.045291983,-0.047376767,0.05043658,-0.055293042,0.0018255593,0.018358301,-0.037452314,0.030902047,-0.051483497,-0.028390255,0.06055808,-0.007494112,-0.0010638847,0.078802094,-0.039277986,0.047842342,-0.035148714,0.12594163,-0.049424607 +1.13.11.26,Also acts on tryptophan.,384,1.0,0.003399296,-0.06754462,-0.04713621,0.055213436,0.006173921,0.029530182,0.09417791,0.0031103946,0.07260337,0.016806126,0.036799982,-0.020746468,-0.093578786,0.1356019,-0.013054187,0.02345959,0.004870609,-0.013257313,0.024230972,0.031592157,0.019899122,0.044155143,0.01687502,-0.023367736,-0.07078987,-0.02506776,-0.015397099,-0.040130068,0.0437628,-0.048090354,-0.027685195,0.017653598,-0.0076018707,0.009531775,0.01778253,0.11377707,-0.01621389,0.03210544,0.057934158,-0.021598546,0.040542018,-0.051417623,-0.014960819,0.011549284,-0.026787335,0.032401886,0.033110857,0.038781025,0.02777115,-0.022782858,-0.06664305,-0.039296553,-0.025925055,0.051117167,0.020566536,0.060955685,-0.043974258,0.0028357985,0.018560903,0.0050827623,-0.04355012,0.07230731,-0.015303227,0.0038204885,0.099423535,0.02433525,0.006414414,-0.08455412,-0.007049465,-0.01129175,0.045112718,-0.034953237,-0.0032337145,0.03045705,-0.014774589,-0.024535298,-0.027878081,-0.118453845,-0.07176808,-0.049546972,-0.049694054,0.0062373737,-0.0077599776,0.0678072,0.041341774,-0.017616298,-0.07062111,0.025528038,-0.03627665,-0.00039410434,0.07082944,-0.05636919,-0.049445607,0.018275086,0.01596191,0.0023394625,0.010222585,-0.09818552,-0.036820237,0.03819074,0.002528615,-0.009243543,-0.048929922,-0.057054542,0.019379478,-0.008493106,0.046242114,-0.049408164,0.037033156,0.030897323,-0.05626349,-0.042344354,0.068381116,0.06564686,-0.015623582,0.04880069,-0.0062034195,-0.001546698,-0.08918791,-0.062153157,0.056408063,0.012848521,0.011869433,0.091265276,-0.048677217,0.05293749,-0.060502768,-1.5278559e-33,0.09219842,-0.05501981,0.0656935,-0.024417318,0.004302629,0.048174072,-0.003123089,-0.044137444,0.076423794,-0.014190591,-0.05349203,-0.16042016,0.04988859,0.040869232,-0.059150983,0.031982724,-0.1311897,-0.006096147,-0.00017141036,0.012124329,-0.06394542,0.0777256,-0.071151145,-0.048172027,0.0098875025,0.049542107,-0.004031718,-0.018044574,0.061780807,0.008673585,0.042137235,0.04620716,-0.15267898,0.041651055,0.009678816,0.09819871,-0.0066510416,-0.00056790997,-0.0707414,0.0012144905,-0.017255798,0.061250176,-0.060768094,-0.0005665147,0.069504656,-0.008638126,0.0054152114,0.0915241,0.05418603,0.020031892,0.030166496,-0.055353865,0.035632823,-0.04323945,-0.043613423,-0.037244406,0.022819793,0.023384986,0.031530432,0.069310755,-0.023157027,0.008391691,-0.025175368,-0.026526473,-0.07095834,0.036960207,-0.09215179,-0.111997634,-0.0048216186,0.04763891,-0.06496418,0.011358721,0.09063838,-0.0024336076,-0.027372757,-0.07870116,0.007982508,-0.040124,0.00659514,0.046811383,0.06876387,-0.14130215,0.07959449,-0.059512835,-0.06300523,0.0020235386,0.009017591,-0.14320576,-0.045766145,-0.05266227,0.06717456,-0.006633187,-0.0031189846,-0.011717611,-0.043387342,-4.0424505e-35,-0.049211815,-0.08784536,-0.009361626,0.043213174,-0.002628902,-0.011014024,-0.07535798,-0.07237131,-0.010867339,-0.006851603,0.08504964,-0.049002107,0.021626946,-0.015193627,0.074842416,-0.012537663,-0.038042102,0.16505499,0.021535201,-0.023203295,-0.042850643,0.073785685,-0.006774301,0.0058089164,0.09233247,0.10095844,-0.042018563,0.013350292,0.031504877,0.010364487,0.0021129395,-0.0055760215,-0.18144302,-0.07364426,0.011811351,0.022357035,-0.053014085,0.015486813,-0.028236242,-0.03693823,0.043154888,0.007384773,0.15047865,0.07214364,0.014231422,0.074837804,-0.005465841,0.053803746,-0.038818464,-0.03464511,-0.04139055,-0.037135188,-0.04996082,-0.0063897693,0.09363384,0.11998542,0.029758964,-0.025559569,-0.027336072,-0.091290325,-0.035483442,0.0027889167,0.02384993,-0.031137625,0.03496855,0.020502783,-0.0012547658,0.069184646,0.12475575,0.02263638,0.053300712,-0.02739168,0.020467507,0.0038612045,-0.095596634,-0.02462846,-0.02040481,-0.052061368,0.023826435,-0.03157098,0.03637285,0.026560077,0.026357394,0.02069002,-0.004908797,-0.033425797,-0.018371278,0.045829244,-0.030284453,0.057354536,-0.062279813,0.02500233,0.035025693,0.043187216,0.03726535,-1.5777797e-08,0.044347163,-0.050537158,0.04719588,-0.041990478,0.022823159,-0.008534969,0.06273382,0.04680373,0.01712361,-0.020760987,-0.0036530271,0.051350452,0.04860943,0.009783244,0.07570648,-0.06020846,0.023769705,-0.010082494,-0.07204168,-0.0018377282,-0.08314125,-0.039812118,0.014603907,-0.020680008,-0.060643766,-0.0064853164,0.03619929,0.09050046,0.010330617,-0.03283521,0.00874892,-0.02585305,-0.009918329,-0.017270636,-0.025490848,0.08799508,-0.018410426,-0.002230687,-0.0027799455,-0.0027721638,-0.024264112,-0.06980251,-0.012642194,0.055388767,0.0017281473,-0.08153474,-0.018087834,-0.037566494,0.051655922,0.013108627,0.016667683,0.023989445,0.031770438,0.019853001,-0.029467119,0.072619505,-0.041047618,-0.031754557,0.016289098,-0.044756718,0.11119242,0.035454184,0.0745809,0.048326533 +1.13.11.27,The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the enzymes from other sources may contain essential iron or copper.,384,0.9999999,-0.0076111513,-0.06547794,-0.07837969,0.081176974,0.12336581,0.026998695,-0.03443154,0.0020403482,-0.04565091,-0.095792666,0.012124034,-0.096472524,-0.047802813,0.0022124157,-0.056982893,-0.053857744,-0.03899612,-0.01162757,0.003871154,0.077576995,0.03605629,0.048560634,-0.011239177,0.02228897,-0.053619362,0.078043096,0.057124555,-0.028708927,-0.03209303,0.025049862,-0.10334606,-0.055729836,0.093463756,-0.03825967,0.05856626,0.010649359,-0.054301925,0.03831361,0.040477023,0.03347351,0.0128919305,0.047687415,0.06317398,-0.0504091,-0.023588803,-0.064966105,0.04651943,-0.03503631,0.074819945,0.002721884,-0.07489117,-0.01759031,-0.027702278,0.100463465,0.030997692,-0.033091813,0.057969783,-0.05527686,-0.07866528,-0.0002791966,-0.0045828777,-0.072457716,-0.07454679,-0.0012754037,0.08217352,0.010108236,0.0532882,-0.029461829,-0.02191962,-0.029674144,-0.047219455,0.034459878,0.0016082352,0.004106949,-0.010302618,0.04812231,0.11713898,-0.07197704,0.07538378,0.0017596618,-0.060636993,0.017520685,0.0179479,0.02817058,0.017080644,0.004558268,-0.014462379,0.02783198,-0.041778907,0.010216035,0.026534272,0.02814778,-0.04743529,-0.105373934,0.02979828,0.08874676,-0.030273916,0.037395176,0.035892,-0.08341691,-0.00626538,0.059214592,0.036550894,-0.0796822,-0.006939162,0.041082863,-0.069095604,0.10769523,0.014795918,0.07856183,0.02263527,-0.03647834,0.056411415,-0.019244336,0.048248146,0.04595609,0.10362259,-0.057665665,-0.0626006,0.06477631,0.05841504,-0.032696076,0.092581235,0.04133626,0.00027488352,-0.034040246,-0.085792735,4.4293803e-34,0.01889608,0.029965006,-0.0114492355,-0.0683097,0.018826084,0.048250515,-0.075805806,-0.009945541,0.009551126,0.0078002177,-0.029813785,0.0024315296,0.020351142,-0.02468383,-0.072426125,0.0013605026,0.0134921735,-0.027553467,0.08871651,0.003563455,0.03881455,0.06642438,0.010210503,-0.02211459,0.042041577,-0.0071065444,0.0083331885,0.0076007214,-0.078316614,-0.03611288,0.05757966,-0.021377793,-0.07781766,-0.053372655,0.1263214,-0.002267386,0.043975133,-0.035893977,-0.02920516,0.032884642,0.06368763,0.05957785,0.034139324,-0.014998782,0.023686128,-0.080255516,-0.13179944,0.124863036,-0.0065451227,0.10768426,0.024294525,-0.02084375,0.060386732,-0.019074878,-0.068024114,-0.019956734,-0.02801765,0.055532575,0.069446675,0.045929734,-0.0077710943,0.02860318,-0.028490746,0.10317892,-0.006107243,-0.021666184,-0.024397109,0.09444773,0.07129461,0.08418787,-0.12651944,0.0420097,0.037676554,0.0043413965,-0.035483778,-0.12127001,-0.06345155,-0.06601607,0.06004772,0.07506431,-0.06676301,-0.040204223,0.039786935,0.0007117428,-0.10982504,0.05355674,-0.024359722,0.035873562,-0.005388784,-0.099048436,0.08187391,-0.04801396,-0.07209852,0.0027053086,-0.02132339,-1.8373902e-33,0.017590737,-0.058903854,0.07665334,-0.05401536,-0.041297168,0.010448176,-0.0033980375,-0.026957378,0.04380651,-0.008965676,0.08121282,0.0009449493,0.032437135,-0.076134734,0.023483915,0.116986796,-0.04517462,0.058002755,0.027913345,0.022082604,-0.01218532,0.00065957825,-0.012222182,0.021207953,0.059460234,-0.002333703,-0.06536429,0.056147482,0.038822312,0.07495977,0.053147264,0.04033799,-0.007727115,-0.08183434,-0.0567841,-0.045880385,0.027760241,0.016358446,0.103211224,0.07169028,0.07629327,0.030281633,0.03211701,0.064059146,-0.06086079,0.060093097,-0.049192693,-0.046558738,0.006708842,-0.014691329,0.0023956024,-0.029780865,-0.080490604,-0.011919193,0.036863282,-0.011088394,0.02090243,0.048075907,-0.034716457,-0.014901803,-0.019081393,-0.056258276,0.0011900533,-0.02025722,0.01100296,0.051482696,0.007417861,0.05018069,0.0021782294,0.0225412,0.02621993,0.06246626,0.014332449,-0.039566856,-0.079611994,0.029652601,-0.011380311,0.017665977,0.0040527955,0.06593411,0.073668726,0.0129982075,-0.015144171,-0.010143922,0.014222359,-0.045570623,0.047094624,0.08687974,-0.071071915,-0.028576868,-0.06727365,-0.03939779,0.037844643,-0.026788905,-0.01863433,-2.3244342e-08,0.013255861,-0.046211436,0.041668985,-0.01805107,0.010925502,0.04597581,-0.010880595,0.00240904,-0.038263246,0.056858756,-0.032269444,0.043882802,-0.06914471,-0.050875474,0.038138986,-0.023727758,-0.079851106,-0.008243797,-0.023159347,-0.054804213,-0.05943132,-0.026197625,-0.07613166,0.0052101077,0.014979253,0.020271264,0.010400553,-0.028716158,-0.033303343,0.033459984,-0.05867025,-0.068297304,-0.030672433,-0.013993784,-0.09491429,-0.022884205,0.012103749,-0.06508529,-0.06475843,-0.0057278355,0.03320409,-0.10502769,-0.058945064,-0.0448584,-0.030492803,-0.035624757,-0.053086206,0.019211473,0.04873191,-0.0655384,0.07684732,-0.05378925,0.036241673,-0.004212487,-0.008952082,0.06682276,0.02288325,-0.028821416,-0.0333323,0.025118938,-0.0015552238,0.008051769,0.10886977,-0.019713072 +1.13.11.28,"Also acts, more slowly, with 2,3-dihydroxy-4-methylbenzoate and 2,3-dihydroxy-4-isopropylbenzoate.",384,1.0,0.020521235,-0.14192887,-0.027016394,-0.006994192,0.043252166,-0.007917864,0.004555013,0.027954767,0.06445088,-0.01436324,0.120267,0.0142579675,-0.06204011,0.08373231,0.00028674016,0.08830216,-0.01030192,0.056815837,-0.015305033,0.008507625,0.007872195,-0.047293562,0.06064497,0.0068599437,-0.017342012,0.051064234,-0.013357084,0.049973395,0.0917,-0.11472214,0.026914025,0.034046344,-0.015888475,-0.046788715,0.025894824,0.054479264,-0.029603845,-0.009745312,-0.0074812407,0.018312892,0.0768037,-0.063261345,0.049753536,0.022426536,-0.02421636,0.007758781,0.021654861,-9.4262934e-05,0.0520704,-0.047203884,-0.08055857,-0.0670511,-0.028583271,0.052611,-0.060352426,-0.012501532,-0.026210168,0.076039374,-0.021138776,0.028005302,-0.040819343,-0.0013271432,-0.038452774,0.01644241,0.0047664177,0.048072778,0.024774242,-0.045751296,0.0021565207,0.061542444,-0.034947786,0.019402742,-0.0014073496,-0.026035707,-0.018111998,-0.043654345,0.0019580193,-0.07109506,-0.017874436,-0.081632316,-0.057618655,-0.008046833,0.014204189,0.0256891,-0.0047108065,0.042088456,-0.0058898632,-0.090167776,-0.05355585,0.001672971,0.0069634914,0.098703645,-0.035404053,0.0017052726,-0.048965808,0.06815706,0.036001995,0.049406372,0.039162077,0.030606316,0.010984284,0.014499797,-0.11695141,-0.08320508,0.011733277,-0.033875026,0.03262369,0.018562578,-0.089199446,0.08017595,-0.055987056,-0.024271846,0.0439356,0.062458165,-0.076140754,0.016764779,0.056479394,0.027841186,0.017181473,-0.04073654,0.016441455,-0.023953807,0.032241903,-0.0610345,-0.0523241,0.054351088,-0.027242787,1.7417572e-33,0.02040808,0.043472353,-0.016251132,0.048336882,-0.008094969,0.011560815,-0.110276416,0.016629722,-0.0608583,-0.06049665,-0.079972394,-0.07249408,0.022465425,0.031052042,-0.05161558,-0.13218272,-0.01841017,0.07813864,0.047061484,-0.06618828,0.006552697,0.09552392,-0.07456035,-0.012605091,0.010318887,-0.02162617,0.019434555,0.005182017,-0.02443641,-0.026733696,-0.0021826513,0.02094599,-0.107779264,-0.03654556,0.049757667,0.04967773,-0.03660831,-0.044049054,0.0531531,-0.03876599,-0.01633255,-0.008871351,-0.07102443,-0.052165538,0.070977196,-0.024635851,-0.056913085,0.110911086,0.020423414,0.038040824,0.116832525,-0.010541201,0.08153232,-0.009536216,-0.03840755,0.011974971,0.018746445,-0.020483382,0.03259672,0.03584005,-0.039477456,0.048492737,-0.032897066,0.025547631,0.04772774,-0.027700495,-0.056382,-0.0028910136,-0.029701905,-0.015318114,-0.006866131,-0.047287077,0.114349715,0.013825018,0.067555435,-0.06338547,-0.07299569,-0.0740439,0.055306643,-0.013516163,-0.057695262,-0.021346418,0.0040081707,-0.031437144,-0.09489087,0.056989048,0.02171101,0.0007137296,-0.00022615246,0.035947282,0.038876217,-0.13071382,-0.04420211,0.011809019,0.035619527,-2.2182172e-33,0.043292098,-0.030176714,0.042236097,0.043602444,0.036230657,-0.008334443,0.021506915,0.024642723,0.04163529,-0.0054210536,0.15057062,-0.065382205,-0.04447957,-0.0121758515,0.035957463,0.06102926,0.043632105,0.009234493,0.033083916,-0.0026867373,0.036137216,0.075790465,-0.018618908,0.13676903,-0.0010396913,0.014055528,0.06786367,0.027319258,0.019754866,0.08773976,-0.045824077,-0.01899222,-0.06435684,-0.07895147,0.0013360358,0.10748072,-0.06157092,-0.027470471,-0.08276808,-0.062111426,-0.03719805,-0.02793811,0.060291417,0.06868456,0.039023165,0.09261106,-0.034372643,-0.0048926272,-0.07489649,0.035966717,-0.0003455404,-0.0040695737,-0.07381455,0.069436,0.06957566,0.03259883,-0.044787426,-0.065454364,-0.06924201,-0.006650253,-0.029659867,-0.01771977,0.05138724,-0.053613976,0.093321115,0.0021238143,-0.04078532,0.0050788154,0.08545384,0.011330607,0.085625954,0.037648913,-0.01626341,0.045478906,-0.07020841,-0.053070568,0.06515725,-0.0705168,-0.10908911,-0.03898597,-0.010834949,-0.0048364527,0.038319122,-0.052174345,-0.16509338,-0.011061207,-0.028252635,0.014631227,-0.050496913,0.07466112,0.056769956,0.07577696,0.035559326,0.05559136,-0.0017798683,-3.638332e-08,0.02495756,-0.031275034,0.099631704,-0.07788564,-0.011571453,0.021752354,0.021804443,0.098080724,0.029577332,-0.053301185,0.05691452,0.05498375,0.08774325,0.04868698,0.04352103,0.014615472,-0.068880156,0.019483978,-0.037663523,-0.07663065,-0.09203512,-0.009243519,-0.019736517,-0.017319825,-0.02587149,-0.02008552,0.013539172,0.065819584,0.039320633,-0.0604375,0.048170466,0.030299129,-0.00302219,-0.03827574,-0.019593848,0.07208237,-0.009661514,-0.024413139,-0.027244134,0.029271957,-0.008197284,-0.043798357,-0.07394572,0.048928082,0.011725268,-0.053205952,-0.009240587,-0.01577387,0.009660677,-0.029932646,0.046492305,0.029633578,-0.011542721,-0.03004413,-0.04864281,0.039822612,-0.04939574,-0.011280864,0.03536588,-0.028962415,-0.01296609,-0.026257131,0.11799313,0.04562566 +1.13.11.29,"The intermediate product undergoes ring closure and oxidation, with NAD(P)+ as acceptor, to stizolobic acid. The enzyme requires Zn2+.",384,1.0,-0.039463826,-0.022625763,-0.13054632,0.018177157,0.053913098,0.023449931,-0.07493364,0.08942079,0.04291973,-0.084769845,0.002318465,0.039780363,-0.052172814,0.031150194,-0.031378143,0.04375295,-0.079982944,0.007276941,0.020625189,-0.04127725,0.050730128,0.02574743,0.032723602,-0.05475142,-0.022377456,0.06789105,0.017483005,0.0008902143,0.061624467,-0.04075478,0.0037537792,0.041857608,0.050637998,-0.032657586,-0.036494073,0.0283301,-0.06307942,0.021771824,-0.011064254,-0.030627519,0.10592517,0.024361944,-0.035803903,-0.042920955,0.0002398995,-0.002738073,0.09464691,0.039341066,-0.005337478,0.026217321,-0.07418695,-0.024631135,-0.026873644,0.04453974,-0.029911153,0.09737147,-0.0637431,-0.025001656,-0.012041636,-0.07905027,0.07075577,-0.060399354,-0.06557229,-0.008561015,-0.0033645,-0.075556904,0.06627869,-0.029109221,0.002079087,-0.01628936,-0.06625384,0.043236163,-0.04308929,-0.0696134,-0.056738805,0.074729666,-0.009603759,-0.100761525,0.023269784,0.0009080548,0.04669463,-0.037288204,0.018225964,0.09153049,0.08799664,0.060765248,-0.026888987,-0.0019886165,-0.032348935,0.0629569,0.010491443,0.035424404,-0.03349364,0.039233852,-0.06314811,0.031950768,0.057635754,-0.0032928975,0.030132685,0.02067984,-0.003647421,0.015188067,0.071036674,-0.10288636,-0.046808977,0.053215027,-0.049065266,0.0794438,-0.0026809117,0.039062936,-0.030092247,-0.048238993,0.021219105,-0.06858049,0.039689198,0.13928072,0.017396448,-0.042851314,-0.064921424,-0.009267409,0.005105819,0.03983277,-0.025276896,0.021677883,-0.07036344,0.019096572,-0.062009033,1.5032984e-34,-0.009282247,0.047773935,-0.023789328,-0.014505863,-0.044501327,0.06372911,-0.08885292,-0.014367804,-0.042248577,-0.030851113,-0.06344746,-0.09395806,0.028655829,-0.01602249,-0.034272093,-0.045915186,0.044853877,-0.021939786,0.046726994,0.045546472,0.05085249,0.059683643,-0.072227105,0.034814842,0.036606014,0.014017029,0.043736964,-0.007698725,0.019417718,-0.024801845,0.07306301,-0.04482447,-0.06528889,-0.0065027736,0.11987071,0.021772984,-0.033908527,-0.008831614,0.014199959,-0.023337664,-0.002606765,-0.019256743,-0.025730984,0.06063008,0.03695459,-0.12041741,0.013025103,0.11614702,0.07440123,0.07317595,0.05148372,-0.0029183032,0.06394901,0.027144784,-0.045493893,0.0057971966,-0.02675538,0.018801704,0.01002822,0.021127163,0.022635458,-0.007043439,-0.10200706,0.12422981,-0.027974835,0.04283653,-0.10804643,-0.026307523,0.016690357,0.0022778537,-0.043824084,0.018463919,0.05136847,0.058147773,0.035831377,-0.02050272,-0.067113236,0.01215721,0.1512128,0.003524246,-0.065964684,0.022861091,-0.08608636,-0.056617558,-0.07178063,0.018447988,-0.021953586,-0.02004956,-6.866238e-05,0.04138963,0.017111365,-0.08154286,-0.007323757,0.058009762,0.103657894,-1.565027e-33,0.10201747,-0.057538282,0.07059999,-0.063861206,0.039912257,0.0694257,0.023994405,-0.12411934,-0.016458714,-0.050422907,0.069333196,-0.002607846,0.015041909,0.03600058,0.015380558,0.0043040914,-0.031228848,0.112171784,0.03857812,-0.029286645,0.059967484,0.09168399,-0.017914077,0.011521646,-0.05315177,0.009509058,0.008790983,0.0065335613,0.061324824,0.11356706,-0.017043406,-0.08281841,-0.07219923,-0.04828445,-0.011489147,0.055208262,-0.086280614,-0.03403357,0.031576794,-0.038406823,0.07371159,-0.07233439,-0.04291201,0.0730447,0.09026108,0.030436974,-0.06452724,-0.001140559,-0.03645371,-0.075169496,0.0581048,0.0540907,-0.06359316,-0.0047739753,0.060388852,0.05167081,0.05072347,-0.0056506917,-0.02507203,-0.04954454,-0.028728507,-0.053734113,0.07264261,-0.041364815,0.026909646,-0.05165504,0.050313912,0.08577874,0.042777963,-0.03530152,0.0076322127,0.11509543,0.011066313,0.042055722,0.0075505488,-0.02443731,-0.090302445,-0.0010606613,0.04370825,-0.042157844,-0.027502252,-0.0054768305,0.033540208,-0.05015677,0.039464425,-0.08285777,0.037099417,-0.035522774,0.01714247,-0.0029874265,-0.003786557,0.0036233582,-0.0660061,0.013087935,-0.001188459,-2.9954965e-08,-0.007163357,-0.030067202,0.0800066,-0.072680734,0.027167562,0.015121145,0.026161667,-0.06493924,0.033084642,-0.048388954,-0.009885077,0.067940876,0.024217663,-0.012192738,0.033666905,-0.022769012,-0.047241054,0.012791474,-0.01323235,-0.09315862,-0.09779059,-0.000944853,-0.046852052,0.04463221,0.00010373636,-0.086792625,-0.036157545,0.0064907013,-0.008915781,-0.0401926,0.08676939,-0.014074061,0.052844193,-0.031621452,-0.02389067,0.020679334,0.06543281,-0.03499353,-0.047055274,0.008542326,0.020076692,-0.076371476,-0.009396673,-0.016005147,-0.005474406,-0.017304868,0.03890081,-0.009606251,-0.05333277,0.053525083,0.060672432,-0.03589813,-0.0470538,-0.05160321,-0.046435315,0.007286579,0.027535142,-0.009062686,-0.046709456,-0.041444033,-0.04619955,0.055155713,0.113955095,-0.016242329 +1.13.11.30,"The intermediate product undergoes ring closure and oxidation, with NAD(P)+ as acceptor, to stizolobinic acid. The enzyme requires Zn2+.",384,1.0,-0.04026241,-0.028879063,-0.12443381,0.0002851238,0.054731637,0.026018906,-0.04478467,0.09814272,0.056096006,-0.07474744,-0.0005775353,0.048492942,-0.047458988,0.035943333,-0.04212211,0.035238013,-0.06401943,0.009847641,-0.00036239598,-0.056506645,0.056059983,0.052803744,0.02917992,-0.04999382,-0.0028786017,0.052367143,0.046239164,-0.030963909,0.05525225,-0.041607674,-0.009829464,0.029671522,0.023248332,-0.030614706,-0.052729066,0.035952512,-0.04029282,-0.011656196,-0.045016613,-0.036867257,0.11829587,0.021839969,-0.046487503,-0.03893418,-0.030816583,0.0049216812,0.077287406,0.050676864,-0.0025268688,0.051932,-0.058037926,-0.03808729,-0.03272536,0.05060562,-0.023219097,0.10375249,-0.08111963,-0.031090343,-0.018343283,-0.06523476,0.048426855,-0.042870894,-0.066822045,-0.0016598777,0.025687216,-0.083028935,0.08557158,-0.04373988,0.0118512865,-0.03325354,-0.07098834,0.037246138,-0.054695312,-0.057938848,-0.056766193,0.069855206,-0.017734854,-0.08432054,0.048369206,-0.0065787225,0.013932386,-0.012398289,0.018465394,0.12554808,0.08690471,0.09227578,-0.07243113,0.002621932,-0.044936996,0.054354236,0.003587607,0.017645704,-0.03156851,0.04079849,-0.064633645,0.033302683,0.07136293,0.006155633,0.034363378,0.017635526,-0.008375355,0.045668703,0.06796024,-0.09790226,-0.053976677,0.034043625,-0.05720371,0.071395285,-0.018384686,0.031436842,-0.01113062,-0.055122938,0.062267534,-0.0936116,0.027882561,0.14082855,0.014334204,-0.0174901,-0.071589835,0.0029993067,-0.013029344,0.05690216,-0.037369046,0.030781753,-0.057167508,0.023726644,-0.068389855,5.3051506e-34,0.013224742,0.017707705,0.010708918,0.022250043,-0.046861712,0.061405268,-0.09387822,-0.023524167,-0.04687508,-0.015800072,-0.028663233,-0.10231307,0.031864204,-0.017449278,-0.012246115,-0.05555653,0.039019126,-0.037742756,0.06267398,0.05610591,0.029556321,0.060200907,-0.06454482,0.041487955,0.018157924,0.019115947,0.042030882,0.01572285,0.029480308,-0.008691284,0.06398472,-0.026956297,-0.093303375,-0.018210795,0.08929708,-0.012993896,-0.016542662,0.0019082958,-0.0013137254,-0.013368512,0.01026638,-0.033871133,-0.05988413,0.030317837,0.050817505,-0.13348678,0.029875536,0.11456455,0.08100923,0.075243115,0.06753421,-0.007177834,0.0980378,0.024015335,-0.05539005,0.008402647,-0.04018318,0.021394761,0.016052656,0.021259975,0.027288841,0.016961494,-0.09512006,0.13197842,0.0021472117,0.05688981,-0.07933066,-0.058532655,0.016497202,0.010985682,-0.03611034,0.018373638,0.054570984,0.046016824,0.042760212,-0.03325566,-0.08176558,0.039937552,0.14515242,-0.0014324996,-0.051704716,0.036203295,-0.06311239,-0.035046376,-0.06653188,-0.015954837,-0.017117595,-0.0324121,-0.009091329,0.04238071,0.011877626,-0.09030803,-0.0088914195,0.04658543,0.082643494,-1.7978042e-33,0.10868033,-0.062025327,0.06462918,-0.04865874,0.03501944,0.07027458,0.020619124,-0.12384838,-0.002123958,-0.036068693,0.0903018,0.006458856,-0.002706108,0.046887074,0.019732544,0.016237797,-0.054156713,0.10235244,0.039348632,-0.027421772,0.054375008,0.074319,0.007291229,0.013425563,-0.052803006,0.00551203,-0.019096935,0.0075075245,0.03317572,0.10084439,-0.0083407415,-0.07779092,-0.081534795,-0.056077298,-0.04352029,0.023230433,-0.07464931,-0.016883021,0.056944903,-0.041171353,0.04903216,-0.0641905,-0.01734523,0.048078805,0.09360099,0.0073545515,-0.06336583,-0.010746117,-0.039574806,-0.062102336,0.03797837,0.08651657,-0.07016561,0.0023888103,0.043993752,0.06264262,0.05959521,-0.004972924,0.013337855,-0.04708824,-0.0411242,-0.04890907,0.07573527,-0.026968943,0.041453347,-0.04168493,0.06903009,0.08321463,0.058054812,-0.03975934,0.028602658,0.09526279,0.046879314,0.033368833,0.04459781,-0.037847955,-0.056419656,0.004953297,0.040584523,-0.030691238,-0.03491939,-0.013928651,0.010261694,-0.05837127,0.053369936,-0.07573298,0.049285877,-0.022794351,0.0045807417,-0.020113291,-0.018453471,-0.016641727,-0.06876243,0.006638899,0.0183437,-2.9708714e-08,0.008402858,-0.03468717,0.040397234,-0.077530265,0.029980721,0.0111953085,0.013513672,-0.03731729,0.015464798,-0.027710471,0.017962277,0.056913015,0.01036239,0.0072064097,0.052123513,-0.024722217,-0.03851308,0.0063418057,-0.029849937,-0.117350414,-0.07661954,0.0015791949,-0.014679858,0.050562125,-0.01693842,-0.099471174,-0.04335657,-0.0066420985,-0.0025889073,-0.016591104,0.06303115,-0.00066618895,0.031247722,-0.04078435,-0.048103098,-0.010062267,0.050294455,-0.014864572,-0.020936003,0.03230475,0.013408716,-0.07755639,0.0020375561,-0.014407308,0.013539406,-0.010936752,0.040590912,0.0039012055,-0.06680918,0.06943675,0.040877514,-0.008352809,-0.05197265,-0.06300251,-0.077824436,-0.0059376406,0.022474255,-0.022950979,-0.04522687,-0.060301527,-0.06339237,0.04935958,0.08540844,-0.039836265 +1.13.11.31,The product is rapidly reduced to the corresponding 12S-hydroxy compound.,384,1.0,-0.0073235147,0.031634558,-0.019468704,-0.012927549,0.045047726,-0.0012309381,-0.006213223,0.06293624,0.023592817,-0.048757743,0.062011115,0.10568516,-0.010098482,-0.027561327,-0.074910626,-0.0007697622,0.014120611,0.035236396,-0.06913893,0.062043283,0.05256286,-0.09352263,-0.0054601477,0.07828531,0.04796446,0.022280803,0.06803144,-0.0021933652,0.02876846,-0.047840025,0.021186212,0.0839027,-0.013048357,-0.09542371,0.0057605775,0.028092237,0.011132833,-0.06826028,0.029131882,0.019810949,-0.01375012,-0.06957759,-0.016524699,-0.018274894,0.028158933,-0.017301016,-0.010760896,0.07554006,0.018951938,-0.04614039,0.00089183287,-0.0067782025,-0.09801905,0.101235576,0.03730339,-0.037446767,-0.1676693,0.0128820045,-0.043661214,0.074711725,-0.03052464,-0.007999017,-0.014905315,0.058175866,0.0077954256,-0.009146772,0.008171552,-0.024769029,0.007019822,0.063327014,0.0070838584,-0.015127902,0.050808083,-0.027062252,-0.011007551,-0.016746854,-0.0009649666,-0.05545809,0.07582743,-0.0044290097,0.033366024,0.020841971,-0.040897667,0.08490491,0.047083784,-0.064828105,-0.030924633,-0.043825466,-0.04154072,-0.023298342,0.007557736,0.026889658,0.0010321896,-0.020690722,-0.07728084,0.012369289,0.073722,0.0067664743,0.021041634,0.02082789,0.014698866,0.058684908,-0.06777513,-0.14809275,-0.104479335,0.03125272,0.045434773,0.08314256,0.04307281,0.066474944,-0.07064273,0.0027365836,-0.052238308,0.033440784,-0.09101802,0.072363265,0.07026813,-0.03077237,-0.042667374,0.023593616,-0.035069156,0.046669014,-0.0040609282,0.003742671,-0.08653578,0.075081654,-0.0005575381,-2.8833471e-33,-0.0018618129,0.014332828,-0.01596396,-0.005604965,-0.017027782,0.03741056,-0.07320639,-0.007792313,-0.033068273,0.00298695,-0.0765751,-0.0011176886,-0.028077232,0.031219779,-0.07139984,-0.13251671,0.041310713,0.04122829,0.10747876,-0.06707476,-0.041353054,0.06538939,-0.07373999,0.012229567,-0.051931728,-0.010652159,-0.004296126,0.026174132,-0.02380911,0.04501711,0.04607779,0.033614397,-0.10788724,-0.0061280807,-0.062085386,0.006399825,-0.031013088,-0.03657081,0.11107439,-0.00047138726,0.017982177,0.0404089,0.01389745,-0.031892996,0.04184994,-0.012930685,0.041211225,0.04599569,0.061480787,0.0023636764,0.019877357,0.016513377,0.022926336,-0.045139816,-0.0075720474,0.027746405,0.018576175,-0.035447948,-0.016531724,0.08371827,-0.028666664,0.08626393,-0.0422274,0.046895925,-0.007647541,0.0036493307,-0.010993232,0.001386346,-0.07896093,-0.022591645,-0.021481348,0.09808134,0.11451208,-0.014765463,0.09338781,-0.025445338,0.061841328,-0.0075293854,0.04404665,0.040357336,-0.0264499,0.013002807,0.008194166,0.010122392,-0.08792747,-0.010335343,0.005970629,-0.015033854,0.0014695581,0.052846745,0.025471296,-0.16433938,-0.048901048,-0.011575152,0.007680259,1.0140256e-33,-0.011972208,-0.054112285,-0.029294362,-0.01859498,0.011207083,-0.031775568,0.09617398,0.03678029,-0.0046933577,0.011665094,0.1078534,0.013942778,-0.023398202,-0.072611526,-0.058339205,0.116423376,0.03394761,0.07034507,-0.012782433,-0.059286192,-0.00077166077,0.0702678,0.0023478847,0.06637379,-0.036038436,-0.00083374954,0.05773002,0.018001573,0.08635283,0.12173945,0.004716606,-0.028834682,-0.10414926,-0.010565016,-0.028799022,0.06921551,-0.057639547,-0.031204177,-0.068178095,-0.075349525,0.06349246,-0.052118484,0.008347508,-0.032123175,0.07471657,0.050398286,-0.0039285,-0.014639454,0.024644624,0.067975864,0.011690824,-0.0027594161,-0.01357923,0.08806583,0.035440944,0.019683504,-0.039038174,-0.00249482,-0.0728732,-0.006207217,-0.0032101397,0.023581235,-0.019395178,-0.033303127,0.063308656,0.0531656,-0.043987084,0.019395782,0.0664904,-0.015110011,0.08591682,0.03574694,-0.032025162,-0.026824707,-0.03931961,-0.07758881,-0.031754594,-0.054950442,-0.081183225,-0.076107815,0.02740417,-0.0022527939,-0.019393202,-0.11561392,-0.06388591,-0.032859173,-0.028516443,0.04235431,0.037779193,0.10229067,0.027676051,-0.009264695,-0.07131778,0.026840914,0.025528481,-1.9989637e-08,-0.011864914,-0.093145534,0.062166076,-0.037364535,0.021579146,0.06790537,-0.026118625,0.10487773,0.07359039,-0.09832083,0.04858885,0.07970055,-0.008836664,0.010672313,-0.04183566,-0.05218349,-0.047946613,0.0029329509,-0.048571225,-0.08060754,-0.030120272,0.01894311,0.0459554,0.0020989291,-0.020238554,-0.037252348,-0.0007062048,-0.0060990057,0.012483402,-0.08237521,0.020252323,0.041428395,-0.071961105,-0.013918339,-0.025831064,0.085701786,0.012409655,0.031595845,-0.01803173,0.068656996,-0.08115975,-0.090534136,-0.077251345,0.046634372,0.043831646,-0.034197338,-0.066034906,0.008918888,0.026878962,0.028802425,0.08647448,-0.0017053371,-0.013862958,-0.036028944,-0.043096244,-0.015577357,-0.01564946,-0.024791965,-0.01174168,-0.029256014,-0.015159252,-0.008602665,0.15185359,0.04074872 +1.13.11.32,"While the enzyme from the fungus Neurospora crassa contains non-covalently bound FMN as the cofactor, that from the yeast Williopsis mrakii contains FAD [2]. This enzyme differs from EC 1.7.3.1, nitroalkane oxidase, in that the preferred substrates are anionic nitronates rather than neutral nitroalkanes [2,3]. The enzyme has broad substrate specificity that is independent of substrate size [2,3]. Some other nitroalkanes, including nitroethane, 1-nitropropane and 3-nitropentan-2-ol, can act as donors, but more slowly.",384,1.0,-0.041172024,-0.086513326,-0.0702164,-0.0625311,0.122109815,-0.022338392,-0.060461737,0.04089228,0.025297567,-0.05624755,0.048330784,-0.07288466,-0.1312796,0.09841499,-0.091057114,0.008181178,-0.03946538,-0.03656305,-0.02267586,-0.0027317246,0.07092741,-0.010839173,0.020912953,-0.04051606,-0.041706316,-0.04434699,-0.0035427748,-0.036738694,0.045377847,-0.06355072,-0.025164975,-0.012690125,-0.024150286,-0.023020903,0.017527632,0.063174315,-0.0043910276,-0.03113451,0.007283447,0.023228608,0.021252248,-0.010842004,0.0077402545,0.0038419822,0.012644303,0.022908403,0.011421614,-0.020408954,0.066897556,-0.070566855,-0.051830247,-0.10316819,0.016887104,0.050352067,0.041779235,0.058738954,-0.02209717,-0.049812045,0.001108123,0.06994863,0.04301541,0.02006251,0.04933334,-0.03273763,0.06812694,-0.014067992,-0.03373442,-0.07185175,-0.030317914,-0.0009959715,-0.015448925,-0.022495914,-0.003594804,-0.05037789,0.024749516,0.096249685,-0.022840505,-0.03701641,-0.01740646,-0.01630469,-0.014161808,0.05698614,0.06292829,0.042197097,0.08180903,-0.051112153,0.002633691,0.028046925,0.033878904,0.095623694,0.012144561,0.061461315,0.02760491,-0.036118913,-0.08543869,0.06989012,0.004925655,0.059143648,-0.017735505,-0.008724734,-0.014882065,0.04877661,-0.015445802,-0.03190712,-0.109540455,0.030473957,0.011053684,0.005325931,0.11030948,0.08953645,-0.012472959,0.041883297,0.028581817,-0.05502746,-0.062440176,0.017836008,-0.033770617,-0.00086055277,0.014407183,0.01489027,-0.02212707,-0.0013861601,-0.022052357,0.024423422,0.008395452,0.07188191,-0.11688187,3.8452404e-33,0.0116379345,0.033419337,-0.09763121,-0.041188926,-0.0100078825,-0.082567535,-0.0602124,0.000662537,-0.009030949,-0.042454872,-0.055934835,-0.0047351313,-0.03148667,-0.026891649,-0.05826121,0.01651308,0.013107896,-0.044487573,0.011834492,0.048202436,0.06330806,0.04665363,-0.059415728,-0.036976855,0.038798552,-0.07767094,-0.052858926,0.06521004,0.0025857815,-0.033166133,-0.004634503,-0.11774261,-0.028808834,0.045420323,0.036269274,-0.024108136,0.01952049,-0.06545687,-0.092595465,0.00045526208,0.02035774,0.042729262,-0.024802193,-0.037145887,0.07842501,-0.038325284,-0.036736574,0.061384913,0.06060587,0.038079273,0.0067464733,-0.030889701,0.023304014,-0.0051146494,-0.03203154,-0.041838374,-0.039948713,0.012899633,0.1445112,0.026057728,-0.07312679,0.016171537,0.010719459,0.021204598,0.031575564,0.060880393,-0.023654863,-0.069294415,0.05052799,0.03430979,-0.05152222,0.0085492665,-0.055126116,0.03391215,0.036675986,-0.12378763,0.019909257,-0.022916006,0.04312656,0.074285224,0.04580011,-0.026652623,-0.012216143,-0.059532356,-0.06815579,0.025340747,-0.03479778,-0.0065423693,0.047616217,-0.04057515,0.070143916,-0.088650264,0.0070009967,-0.002020142,0.06347376,-3.2806622e-33,0.059585568,-0.09143302,0.067615576,-0.05918565,-0.06303426,0.1338544,-0.034669705,-0.006161437,0.0024310353,-0.05618257,0.04071043,-0.03964945,0.024142073,-0.03957605,-0.0070703216,-0.00063054246,-0.03580675,0.07539616,0.057676222,-0.016720645,-0.064532384,0.1386259,0.007853334,0.048540168,0.05701917,0.064494304,-0.029084116,0.10361953,0.016919253,0.02383688,0.0046295826,0.020029115,-0.09223397,-0.018654227,-0.01784632,-0.017400945,-0.058169354,-0.016545705,0.013696403,0.054814786,0.05387736,0.0548943,0.037437033,0.08413984,-0.11720839,0.06277164,-0.13506356,0.045500312,0.11623091,-0.060630225,0.013190826,0.028797597,-0.049036283,-0.035391603,0.07868726,0.050054375,0.082584105,0.026205508,0.025546007,0.0007258414,-0.023798127,-0.058261696,0.015273022,-0.009283896,0.02596322,0.10229855,-0.029077137,0.09622989,0.04235976,0.057264965,0.020832047,0.050171312,0.06985759,0.026484482,-0.061272886,0.005635981,0.026106372,0.016778558,0.03321795,-0.018645765,0.055303834,0.008087548,-0.04477638,-0.03193921,-0.03422161,-0.024848802,0.041941978,0.025639752,0.0017374757,0.010839575,0.055662036,0.03550387,-0.0037339402,0.05438506,0.07769313,-4.258004e-08,0.09066386,-0.05612315,0.0761467,-0.0603287,-0.0019610329,-0.009108883,0.04653325,-0.03764877,0.028376363,0.067665525,-0.0032670973,0.07170264,-0.012359629,0.0040167067,0.005955853,-0.0118825,-0.010508879,0.048402824,-0.00025439472,0.047444195,-0.022507159,-0.005359917,-0.11236387,0.002343558,-0.013085757,-0.04412451,0.101816505,0.07671512,-0.029824376,-0.033842124,-0.07007939,0.03764541,0.015826995,-0.026982931,-0.08223625,0.020811956,-0.039286874,-0.03897526,-0.14353229,-0.02916568,0.0057514156,-0.028912038,-0.017354026,-0.041216485,-0.061002403,-0.041660298,-0.01980722,0.023763856,0.023742847,0.0031123366,0.08684557,-0.05485281,0.039592218,-0.034048878,-0.09806524,-0.023034187,0.008402722,-0.017657604,-0.032466,-0.061017644,0.006374023,-0.025407335,0.14470337,-0.016871914 +1.13.11.33,The product is rapidly reduced to the corresponding 15S-hydroxy compound.,384,0.99999994,-0.044267002,0.04877729,0.03374957,-0.009206616,0.10183961,-0.029252144,-0.005743615,0.06822895,0.033731144,-0.05844665,0.088298015,0.03080519,-0.004472298,0.016624717,-0.08721039,0.047761697,0.05207463,0.011116306,-0.044254113,0.0060832924,0.020966303,-0.10629479,-0.016987376,0.083589725,0.02168465,0.06351418,0.06114034,-0.018417824,-0.042850293,-0.07748681,0.03642452,0.08237928,0.018231418,-0.12485721,-0.020282045,0.026397347,-0.0102069955,-0.062128298,0.06510693,0.019093743,0.017239304,-0.08094688,-0.05578292,-0.018770473,0.026151873,-0.061084826,-0.015138951,0.092474185,0.053093143,-0.02251972,-0.029416934,-0.026893435,-0.048019916,0.07283991,0.0030546964,-0.07092005,-0.11575792,0.023024943,-0.005330639,0.05894235,-0.00010854344,0.013145898,-0.08748858,0.03736084,0.003457507,-0.01543318,0.03525056,-0.07755584,-0.0002214337,0.08240628,-0.013045883,-0.028961295,0.04165486,-0.020542296,-0.008242868,-0.002708421,0.02654859,-0.055806156,0.09688897,0.01624763,-0.0059414646,0.043237835,-0.024047732,0.07516941,0.041359913,-0.032602035,-0.032183837,-0.020241633,-0.013534976,0.010087545,-0.04899013,0.026764613,0.0019391862,0.019000215,-0.0806566,0.030501308,0.04722542,-0.0016413269,-0.013497871,0.016199064,0.010982856,0.040867515,-0.026679501,-0.10874948,-0.1374248,-0.015974456,0.077518225,0.054434374,0.04096228,0.06727329,-0.046601556,0.0034408998,-0.02820984,-0.012196715,-0.11057157,0.12386728,0.04742643,-0.027722716,-0.04795404,0.0024937857,0.006151463,0.013205174,0.0018054708,-0.017457908,-0.08939683,0.0516593,-0.0066456185,-2.2996703e-33,0.026959175,0.029332114,-0.010384344,0.0103650885,-0.03636274,0.021784881,-0.04969335,-0.013417712,-0.03607392,-0.014907917,-0.08563447,-0.021685533,-0.023425145,-0.0021264865,-0.06347054,-0.10552473,0.031352278,0.04707735,0.09193984,-0.03476492,-0.053045217,0.08435924,-0.0817178,-0.0041012634,-0.023865083,-0.0679799,-0.036437113,0.0064889286,-0.0064231893,0.036636885,0.011664424,0.04592887,-0.10968004,-0.035197176,-0.036558855,0.034723774,0.035888284,-0.06462172,0.12018423,0.047748152,0.011352374,0.037216336,0.040235516,0.010705966,0.076370224,0.027584665,-0.03949388,0.04325446,0.053774066,0.011020762,0.041013487,0.06664094,-0.00866179,-0.052867487,-0.036166478,0.066138186,0.02311905,-0.013566938,0.0008387748,0.056635484,0.004758314,0.07092823,-0.017594362,0.03223458,-0.02003351,0.011462055,0.0014312814,-0.01898389,-0.026744751,-0.0022378764,-0.046849597,0.08591174,0.14769413,-0.024909036,0.10715963,-0.038049188,0.05167785,0.0120244855,0.08072157,0.04443261,-0.07932806,0.004256596,-0.0030190249,-0.044572506,-0.05425912,-0.008965452,0.005577697,-0.015874796,0.028464748,0.015218211,0.017068392,-0.17875749,-0.02359136,-0.016337927,0.0003742166,1.2718735e-33,-0.012082134,-0.053337436,-0.009265315,-0.0071274326,-0.009441462,-0.051287957,0.07468176,0.038731225,-0.012124128,0.018690754,0.12142069,-0.022143736,-0.023578128,-0.061119363,-0.022479504,0.12307227,0.01565209,0.05932967,-0.061740432,-0.033096306,0.030057741,0.053593546,0.008547781,0.073863044,-0.022998111,0.0014877755,0.045572337,-0.01991853,0.09279686,0.061646346,-0.002376563,-0.007193615,-0.086511396,-0.015045878,-0.004979974,0.06481299,-0.054280154,-0.024995193,-0.05428147,-0.09605431,0.037629765,-0.058770753,0.024403036,0.020122942,0.04330575,0.089681186,-0.040435683,-0.057248697,0.019355776,0.024296222,0.010402301,0.02480376,-0.0423723,0.06183108,-0.02135566,0.03721725,-0.034326773,0.034260366,-0.035543006,-0.033889435,0.009181225,0.024213968,0.025743766,-0.03368289,0.065500446,0.040983785,-0.058775492,0.000892444,0.08532218,-0.005259017,0.035819594,0.013652615,0.015399259,0.0020217197,-0.0027510386,-0.06554393,0.024202118,-0.0501312,-0.049189243,-0.046200313,0.07278344,0.026227137,-0.027293509,-0.17767794,-0.0755525,-0.02658613,-0.031957887,0.021764591,0.03174521,0.11585941,0.017378787,-0.0060783164,-0.062081907,0.03675664,0.037022386,-1.937461e-08,0.022684228,-0.08018205,0.0404079,0.0019513138,0.0025809908,0.05759856,-0.021199698,0.097019896,0.09881024,-0.057508804,0.05116009,0.04914356,-0.015962962,0.017496355,-0.010263049,-0.06753619,-0.016885772,0.00957427,-0.031360704,-0.112870336,-0.022475554,0.070429444,0.03666688,0.0014271152,-0.017616604,-0.02380726,-0.021633867,0.0008787871,-0.030286096,-0.07992472,0.020413322,0.040907122,-0.015664615,0.034105703,-0.023046019,0.053542156,-0.014243246,0.039444663,-0.0130345635,0.08286801,-0.08645001,-0.10225348,-0.05412739,0.025036134,0.04395927,-0.030530736,-0.04967182,0.05398031,0.030527439,0.039297644,0.050601486,-0.044333715,0.008962456,-0.051839154,-0.030203033,-0.020812087,-0.03550255,-0.018570619,-0.042215113,-0.073927574,-0.018279022,-0.031292725,0.13944638,0.027909426 +1.13.11.36,"An iron protein, requiring additional Fe2+. Not identical with EC 1.13.11.1 (catechol 1,2-dioxygenase), EC 1.13.11.2 (catechol 2,3-dioxygenase) or EC 1.13.11.5 (homogentisate 1,2-dioxygenase). Involved in the breakdown of the herbicide chloridazon.",384,1.0,-0.03724637,0.033015393,-0.073790684,0.010608406,0.14995351,0.034033738,0.022379188,0.048605297,0.033724047,-0.0894898,0.06513447,-0.039624576,-0.06380824,-0.0431796,-0.05354976,-0.009421233,-0.052487403,0.035384703,-0.058968116,0.01850698,0.0066202213,0.045498136,-0.0049374863,-0.0019824249,-0.08527641,0.04162143,0.0075846664,0.026527513,-0.036255077,-0.10736544,0.049892806,0.043541044,0.039004017,-0.05413691,-0.031359423,0.039548952,0.020381559,-0.12548527,-0.01717398,0.061088175,-0.03963489,0.0220409,-0.03875849,-0.023170855,-0.03992868,-0.10654444,0.028265078,-0.008869337,0.022065127,0.021676874,0.024913035,-0.038568195,-0.041930985,0.041125085,0.05385017,-0.021748416,-0.05682995,-0.0032397783,-0.06971467,0.027254546,-0.023579746,0.033421237,-0.027486943,0.039722748,0.040884666,-0.023263108,0.035207145,-0.06183214,0.03493954,-0.047311638,-0.00402839,-0.08301343,-0.088134184,0.00085089856,-0.04388664,0.06482322,0.042889122,-0.046394907,0.05252446,-0.08490058,-0.06569033,-0.010770134,0.02530551,0.03698162,0.06404704,-0.0007931519,-0.03116466,-0.035980552,0.018832972,0.06773478,0.060498506,0.042092312,0.039428767,-0.0038967398,0.0055250176,0.08726113,0.015026081,0.012658162,-0.051074512,0.026618851,-0.03742784,0.095151484,-0.0460773,-0.065855205,-0.010535512,0.023530874,-0.033772696,0.074701436,-0.013520851,-0.03411877,0.024390733,-0.03576492,0.02371223,-0.032956883,0.03411949,0.03952525,0.06914451,-0.07270936,-0.01571244,0.022879906,0.061967526,-0.0057645314,-0.052305374,0.047216497,-0.050911166,0.03643765,-0.07175539,1.5307698e-33,0.07367729,0.012143203,-0.0021507177,0.011671483,-0.003020348,0.0007270903,-0.11825009,0.021702664,0.00023370965,-0.019513575,-0.097499795,-0.05473168,-0.012278144,-0.038892858,-0.007959263,-0.12005555,-0.03777818,0.011486356,0.09612235,0.013191847,-0.028787175,0.111647286,-0.04971151,-0.023515921,0.016542492,0.032402303,-0.052448727,-0.028345602,0.015641619,0.016454142,0.027370527,-0.04940752,-0.113278955,0.015831321,-0.008562901,-0.027737405,-0.012663105,-0.055865116,-0.052525755,0.03305605,0.028836777,0.056413375,-0.036013525,-0.012330459,0.1137359,-0.0842328,-0.016570179,0.109551996,0.046110783,0.030856369,-0.0430516,0.03937946,0.09629062,-0.02866017,-0.051031105,0.03297861,-0.021530526,0.025583697,0.050846696,0.13924757,0.03173777,0.11873175,-0.018963167,0.07261457,0.11401758,-0.020872133,-0.043231692,0.037873518,0.048446726,0.06959378,-0.058649946,0.014135964,0.07579512,-0.002073563,0.082362436,-0.101523496,-0.08167377,-0.028850585,-0.0049110856,0.06208909,0.011672071,-0.017484559,-0.008841267,-0.059869874,-0.09531119,0.08807852,-0.007151037,-0.020830244,0.015336924,-0.051721334,0.0677674,0.021799322,-0.05540528,-0.056925602,-0.0010511463,-2.1128495e-33,-0.03334279,-0.080723226,-0.0023932483,0.010713472,-0.02532065,0.050841916,0.014510066,-0.03907781,0.0014335411,0.032159477,0.15824917,-0.04378276,-0.0023051382,-0.119270064,0.04124268,0.07368375,-0.082102545,0.04092103,0.03344263,0.052424554,-0.051730506,0.033703882,-0.04548466,0.07894068,-0.0020021459,0.029237807,-0.081846714,-0.013539499,0.09496703,0.010100294,0.028794978,0.015348073,-0.014287961,-0.019566998,-0.017259603,-0.0063420837,-0.028727574,0.004885527,-0.0016416169,0.015126971,-0.0071434947,-0.017294357,0.038204696,0.09555733,0.029218161,0.013252551,-0.086729504,-0.0015596906,-0.0049481955,0.0021239815,-0.027919762,0.030544687,-0.053423826,0.044968344,0.024652846,-0.039353747,0.04791015,0.021966284,-0.003961425,0.106539205,0.03968285,0.01764447,0.00931788,0.073369235,0.07976737,0.017803788,-0.07489307,0.08443188,-0.009211836,0.048401527,0.05099168,-0.0061446843,0.0700601,-0.092604846,0.00025430456,-0.033277344,0.04027981,0.0019380423,-0.069505624,-0.0009679975,0.030512901,-0.015289173,0.015907757,-0.026808495,-0.032817435,-0.09309922,-0.058570765,0.01615248,-0.0009130865,0.05109696,-0.04550471,-0.05896887,-0.036668044,0.06656936,0.023935637,-3.924172e-08,-0.020029383,-0.050431207,0.02934855,-0.050823558,0.056554932,0.006258451,-0.011259568,-0.033170167,-0.0050995885,-0.003883701,0.00042279114,0.11944237,0.0155627625,-0.005576561,0.04595535,0.009876053,0.009512305,0.03426805,0.036260802,0.023025315,-0.034259636,0.025334453,-0.0804626,-0.08730132,0.013495388,-0.03570531,-0.028605143,0.03802289,0.088509925,0.023498226,0.008558144,0.020067856,-0.0112158265,-0.074984804,-0.037813596,0.029385516,-0.07484744,-0.06654585,-0.07414725,-0.019041287,-0.045449764,-0.029842364,-0.068908975,-0.014768547,0.085150935,-0.030280618,0.04325609,0.035785202,-0.0033996813,-0.04404176,0.0541308,0.0028418235,0.08007289,-0.023416014,-0.04116809,0.07434706,0.005844313,-0.09162259,0.025916988,-0.0813706,-0.02082955,-0.026132097,0.1375685,0.003020695 +1.13.11.37,An iron protein. Highly specific; catechol and pyrogallol are acted on at less than 1% of the rate at which hydroxyquinol is oxidized.,384,1.0,0.029345442,-0.09973017,-0.04074649,0.060351856,0.08552808,0.034400057,0.019692251,0.05691623,0.06638859,-0.08196463,0.008610833,0.032403458,-0.06247302,0.009941512,-0.021786654,0.044759188,-0.022799708,0.04450645,-0.062280055,0.05129018,-0.015582687,-0.05605973,0.072873235,0.037858017,-0.038536415,0.024829283,0.020629864,0.05379975,-0.09647671,0.00046553704,0.014526207,0.029680528,-0.023666268,-0.05357421,-0.034363814,0.05531841,-0.024688978,-0.112337485,-0.004525664,0.022678802,-0.0064460067,-0.06635186,-0.061576962,-0.00904978,-0.010555937,-0.0046803756,0.08191337,0.046479337,0.0013424769,0.09216468,-0.038116544,-0.030040205,-0.06993201,0.009762899,-0.020660484,0.026781214,-0.0340297,-0.05621696,-0.03222764,-0.013573701,-0.042170305,0.03906133,-0.047220528,0.05572098,0.007875136,-0.0127312355,0.025366817,-0.017663928,0.025304057,-0.013582645,0.0010022926,-0.057945605,-0.030278426,0.032209244,-0.072591946,0.024078397,0.023219623,-0.08868783,0.10230828,-0.04987324,-0.054985534,0.016000006,0.0063217906,0.12991439,0.08917757,0.004508804,-0.024454234,-0.061003737,-0.01713852,0.06924916,0.017869595,0.035547685,0.026638668,-0.0013479737,0.043131396,0.03838076,0.0594884,-0.003312749,-0.006770307,-0.003109069,-0.061262395,0.07168588,-0.04025177,-0.056812346,-0.06786636,0.0061167986,-0.041758973,0.080682725,0.01800126,0.0005220184,-0.0074635325,-0.031077001,0.01544515,-0.031927515,0.032440756,0.06703866,0.10292526,-0.020676315,-0.08775207,0.0034417608,-0.010521112,0.030355526,0.018184775,0.017666746,-0.09615968,-0.022228234,-0.027343553,4.2454916e-34,0.04812243,0.023334553,0.0203453,0.016926803,-0.02931199,0.009908263,-0.09711225,0.013859635,0.031717625,0.017510429,-0.10040553,0.016606346,0.026643736,0.03432457,-0.030543828,-0.058130804,-0.034511846,-0.013625266,0.098447554,0.008345144,0.028465088,0.12833998,0.07770212,-0.042685896,-0.04861255,0.018991044,-0.0743596,-0.009086501,-0.09048609,0.020146063,0.035737798,-0.088527516,-0.112543985,-0.048638124,-0.035540763,-0.0394079,-0.0614831,-0.053714883,-0.020977212,0.0649744,-0.022259703,0.003072966,-0.036242023,-0.0022047865,0.07960276,-0.018967254,-0.05349485,0.095034316,-0.052727778,0.013449934,0.03574204,0.0330157,0.02648948,-0.0309027,-0.07344074,-0.028904356,-0.02549206,0.0040389057,-0.0070903455,0.10897728,0.070769124,0.09043059,0.081508055,0.010755048,0.049408972,-0.025190506,-0.015632885,0.06423835,0.018582374,0.05256362,0.011466019,0.07209414,0.08728083,-0.027643379,0.0598107,-0.038112327,-0.108960755,-0.028854337,0.014708849,0.048880592,-0.070706874,-0.07651033,-0.009569183,-0.0137589155,-0.057927355,0.061433677,0.052760124,-0.0052289376,0.002276211,-0.018994495,0.058832057,-0.04684649,-0.015254736,-0.08073625,0.039818604,-2.791566e-33,-0.0058448617,-0.103119604,-0.038191315,0.027090855,-0.034382463,-0.03748488,0.017257944,-0.015340577,-0.011670877,0.07041484,0.081354074,-0.033959232,-0.022163441,-0.08220244,0.0065174615,0.05046675,-0.13204005,0.02849588,0.048050925,0.04151714,-0.004121272,0.014749559,0.019391043,0.12129808,0.05616325,0.009455187,-0.12444777,-0.08028413,0.10157252,0.064263,-0.0014696465,0.029820967,0.031588886,-0.10145545,0.02848599,0.027180325,-0.06216475,0.03219161,0.07047984,-0.0016822078,0.05523898,0.011131254,-0.028299002,0.016561877,0.04881538,0.05153379,-0.11946941,-0.053508084,0.0024985445,0.02827873,0.062485415,0.025364794,-0.0061000027,0.022942096,0.041230064,0.039322827,-0.029375358,-0.02740967,-0.006992139,0.10737875,-0.026485125,-0.042497072,0.028928803,0.034634776,0.042859595,0.0574495,-0.017060671,0.053154584,0.05689527,0.023468204,0.12916647,0.013466654,0.08224495,-0.0012101241,0.038645457,-0.034417633,0.0651595,0.017994743,-0.057587318,0.014475391,0.015270599,-0.027958436,0.0084538525,-0.062495366,-0.04834384,-0.034076687,-0.02550558,0.0012827135,-0.030432833,0.021335525,0.019031052,-0.04058074,-0.009466278,-0.022750469,0.02040276,-2.9936587e-08,-0.04380137,-0.060423367,0.03894161,0.0006771999,0.026600901,0.01955941,-0.022740083,-0.04493265,-0.016988711,-0.026119845,0.068044454,0.09634275,0.028455757,-0.034275007,0.029353341,0.0025551033,0.028300392,0.0007783616,-0.001716994,-0.032315325,-0.041172147,0.06254512,-0.02660664,-0.0359593,-0.0029208623,-0.09049973,-0.05353343,-0.032791197,0.02850626,-0.039673932,0.00077356986,-0.00019126816,-0.022959705,-0.043607663,-0.03322423,0.054687098,-0.05953397,-0.069357984,-0.05048322,0.002337326,-0.13381626,-0.07611007,-0.016319001,-0.01334664,0.074635305,-0.040261928,-0.006900502,-0.0024269582,0.017891506,0.020924864,0.058522336,0.0143891135,0.07372766,-0.085887454,-0.10456709,0.12199321,-0.019109458,-0.069649786,-0.033603564,-0.11729293,-0.032369748,-0.052968085,0.073574916,-0.07026186 +1.13.11.38,"Requires Fe2+. Involved, with EC 4.1.2.34 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase, in the metabolism of phenanthrene in bacteria.",384,1.0,-0.00800526,-0.019674677,-0.06465119,0.027377844,0.013283679,0.029851366,-0.08430843,-0.009085448,0.014643155,-0.03786373,0.033081483,-0.13463953,-0.06316738,0.050117943,-0.059777044,-0.024630668,-0.09348655,0.024274202,0.030255964,0.025681632,0.06052863,0.019275932,0.04777365,-0.034178693,0.0058897804,0.037570633,0.025859289,-0.025623139,-0.042982634,-0.03930775,0.03813514,-0.109925225,0.061410937,-0.06271917,0.0017310304,0.0915813,-0.03163375,-0.0891635,0.041750953,0.07371571,-0.030731134,-0.023340827,-0.036365684,0.03199531,0.0023416998,-0.04826286,0.031579517,0.031047825,0.016533323,-0.0029215699,-0.07749775,0.017146992,-0.06780215,0.06253895,-0.0051552686,0.024854762,-0.031062335,-0.016664706,-0.018183839,-0.0048234123,0.03258814,-0.011672767,-0.009747004,-0.013225962,0.0064332364,-0.020733353,0.015496757,-0.071319304,0.013664967,-0.025680952,-0.017974587,-0.043576367,-0.015232628,0.035741534,0.016284373,0.06073365,0.036248002,-0.07853858,0.0139577575,0.012403403,0.028459933,-0.053094238,-0.012054882,0.04399893,0.08740621,0.009654547,-0.029681524,-0.043134995,-0.044449493,0.05601215,0.0320057,-0.013559382,0.00052346865,0.02713844,0.020443723,-0.024343532,-0.023156496,0.03723002,-0.013224164,-0.021962749,-0.058527224,0.059113007,-0.055787563,-0.035318688,-0.04187035,-0.037793864,0.0688339,0.14168471,-0.044985216,-0.004725865,0.04335205,-0.0022854179,0.032636106,-0.053039763,0.041942373,0.10012057,0.018427357,-0.0997861,-0.05777752,0.017238326,0.014111241,-0.072171316,-0.0048558535,-0.0033517343,-0.048202105,-0.012065925,-0.06438386,2.1540328e-34,0.13281578,0.061527394,0.035686277,0.014233353,-0.0065519824,0.033719216,-0.11963586,-0.0012630117,-0.014625409,-0.12856317,-0.042519238,-0.101151064,0.050722357,0.034657486,-0.005470311,-0.04910833,-0.0096306205,-0.022614306,0.123093545,-0.034752313,0.02562248,0.042129423,0.02897393,0.04338999,0.047667753,0.05532567,0.032102033,-0.00397959,-0.04846117,0.0077251834,0.0564096,-0.12337708,-0.11871733,-0.020281177,0.0065660225,-0.017471489,-0.058045384,-0.041293886,-0.059230767,0.048543576,-0.019256344,0.07776183,0.07724772,-0.016779048,0.07550939,-0.025873063,0.006138731,0.1800753,0.037207335,0.12184695,0.0440286,0.006070796,0.07032071,0.029142195,-0.07258152,0.045770478,-0.038907465,-0.0028100032,0.04050127,0.025934683,0.07799489,0.11442276,0.05468854,0.056537595,-0.0072592213,0.05502172,-0.10493928,-0.010700415,-0.01469308,0.088733725,-0.08192304,-0.034557868,0.075561926,0.028210178,0.05751128,-0.011584218,-0.08538959,-0.073463954,0.0045084893,-0.038323615,0.018718032,-0.00688391,0.045162503,0.07333249,-0.050048556,-0.0016672816,-0.020641102,0.023743913,0.037901692,0.061827432,0.05983351,-0.028445983,-0.08937725,0.0047134315,-0.01095522,-9.9218005e-34,0.07458754,-0.10648463,0.0020528084,-0.026716601,-0.029264662,0.048886012,-0.02520839,-0.061140973,-0.0061356556,0.0010429053,0.10910825,0.0050598457,0.029525869,-0.091593,0.09276866,-0.014533621,-0.04069679,0.008292531,0.025525237,0.029765347,0.03289132,0.006179109,-0.019341193,-0.0028538906,0.12099934,0.04745861,-0.01607045,0.017326767,0.034851354,-0.026142593,-0.04522917,0.03322798,-0.063606784,-0.059785113,-0.025170917,0.08400148,-0.03558168,-0.024412742,0.023938945,0.05227416,-0.025887763,-0.011112617,-0.000498581,0.065442055,0.038145445,0.01298263,0.025262628,-0.036021058,0.026789058,0.009268439,-0.002570576,0.012956939,-0.07771651,-0.020683926,0.05485581,0.047491528,0.004269932,0.028376536,0.02036205,-0.0046564373,-0.015204225,-0.05787691,0.09022932,-0.045103684,0.03095641,-0.033449877,-0.012995129,0.10796408,0.07196709,-0.016039802,0.07021478,-0.020601485,0.07707014,0.034982458,-0.056388,0.014054591,-0.060048636,0.013414414,0.0066603483,0.06906202,-0.039136015,-0.0050430647,0.052367456,-0.042833228,-0.0016532844,-0.09125187,0.07981291,0.0042525316,-0.073856086,-0.012207548,0.013630282,-0.06638856,0.0062883627,0.02515377,0.0023165424,-3.557323e-08,0.01809185,-0.038033385,0.0020832475,-0.03340336,0.020698778,-0.011667446,-0.0083062425,-0.03743439,-0.025669072,-0.04962418,0.058502,0.05003801,0.064246885,0.03887036,0.04161509,-0.03698675,-0.051495735,0.015536345,-0.064849555,0.006873748,-0.10874445,-0.037988435,-0.17813943,0.015604562,0.021472244,-0.037444405,-0.007913232,0.013713378,0.018771878,-0.009741976,0.06352075,0.006959837,-0.0011584145,-0.06519671,-0.08634672,0.023791041,-0.06462557,0.0037799897,-0.07520995,-0.00040608217,0.0022588773,-0.042099178,-0.023028051,0.07114904,0.068229266,0.048751675,-0.031767607,0.045773517,-0.072340526,-0.048741665,0.037671037,-0.040201105,0.01628778,0.00023708257,-0.071086146,0.061617427,0.019303743,-0.065413356,0.027087495,-0.06342383,0.027782742,0.012898132,0.11287998,-0.023681672 +1.13.11.39,"Contains Fe2+ or Mn2+ [3]. This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls), and catalyses the first ring cleavage step by incorporating two oxygen atoms into the catechol ring formed by EC 1.3.1.56, cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase.The enzyme from the bacterium Burkholderia xenovorans LB400 can also process catechol, 3-methylcatechol, and 4-methylcatechol, but less efficiently [1]. The enzyme from the carbazole-degrader Pseudomonas resinovorans strain CA10 also accepts 2'-aminobiphenyl-2,3-diol [5]. The enzyme from Ralstonia sp. SBUG 290 can also accept 1,2-dihydroxydibenzofuran and 1,2-dihydroxynaphthalene [4]. The enzyme is strongly inhibited by the substrate [1].Not identical with EC 1.13.11.2 catechol 2,3-dioxygenase.",384,1.0,-0.020215038,-0.04198652,-0.09125508,-0.0745978,0.077551685,-0.0013561381,-0.05990948,0.03448385,0.045540877,-0.05677853,-0.008766709,-0.03225054,-0.021222407,0.016112844,-0.024229012,0.09041927,-0.0606107,0.05329581,0.0057406365,0.0753002,0.051981553,0.025066836,-0.042816076,0.028993163,-0.01304615,0.06834439,0.079207644,-0.031949412,-0.052076083,-0.03937896,0.050416764,-0.048057877,0.09387499,-0.03771804,0.060762867,0.09036912,-0.0404685,-0.032641523,0.02976991,0.0056883725,0.010543546,0.0151014365,-0.00017088653,-0.08483896,-0.03415392,-0.076792054,-0.0075866845,-0.00803995,0.024188573,-0.06762861,-0.03905467,-0.013159728,0.04065185,0.039689507,-0.0055410513,0.01786247,-0.0008791606,-0.011522998,-0.04454604,0.008282819,-0.014033358,-0.009580509,-0.0023558177,-0.00081461243,-0.08938962,-0.013196655,-0.028017681,-0.034097854,0.06818822,-0.019272514,-0.06640776,-0.03549443,0.002184966,-0.050512448,-0.02751565,0.035647374,0.103928894,-0.013532559,0.05632525,-0.110412896,-0.01454838,-0.06319859,0.08390592,0.03231096,0.02843136,0.03747175,0.018016845,-0.0040958407,0.01310182,0.0689207,0.06659466,0.095362276,0.061268978,-0.07567527,0.006092587,0.069694415,0.03953151,0.003243442,0.06633825,-0.002604512,-0.028600775,0.10014709,-0.021392468,-0.12875187,-0.035460215,-0.010546101,0.00839397,0.11375042,0.08149546,-0.03195917,0.015753932,-0.027339714,0.038883433,-0.0010048599,-0.005709741,0.083042994,0.059455127,-0.047004618,-0.032596197,-0.0098683955,0.010218589,-0.07933237,0.009073773,-0.025812753,-0.023084965,0.088615604,-0.09227901,6.81296e-33,0.045631655,0.02573095,-0.07900158,-0.025287705,0.012358242,-0.024130901,-0.07073169,0.042248294,-0.06020079,-0.10176577,-0.038408853,-0.04944222,-0.0074292272,-0.03134115,0.0005883752,-0.058560252,-0.07913403,0.024295326,0.06743725,0.06230331,0.061443496,0.010481492,-0.047886103,0.02386714,0.065452866,0.024223926,0.032296177,0.008972675,0.008367693,-0.011107007,0.0027211239,-0.049833752,-0.16317493,0.01904909,0.03289312,-0.019686067,-0.032320164,0.0013850428,-0.025205804,0.053337682,0.036655214,0.0133756185,-0.032086004,-0.00079563697,0.127115,-0.051654205,0.027660899,0.13309239,0.0017055518,0.100569665,0.003331485,0.016037209,0.068778396,-0.0010500822,-0.095943525,-0.028506532,0.018446261,-0.007147689,0.05616677,0.028435742,0.042019855,0.12312202,0.00049981097,0.041439563,0.07000728,-0.06606847,0.026589911,-0.013602005,0.040762562,0.014988854,-0.046971988,-0.018772956,0.043344207,-0.0013113037,0.03929462,-0.059426308,-0.058874737,-0.013323726,0.059702095,0.01641785,-0.006642372,0.008944718,0.062069964,-0.0791382,-0.043566722,0.04962278,-0.022013832,-0.05849894,-0.05259006,0.035442673,0.045733534,-0.096516296,-0.011886796,0.04221599,-0.0064132996,-4.497669e-33,0.07701952,-0.102038294,0.04754643,-0.015300418,-0.08588018,0.042629562,0.016667113,-0.013097908,0.012385693,-0.09403748,0.10739152,0.025628148,0.06290159,-0.008869146,0.049619693,0.03904568,0.010477038,0.049248017,-0.056482293,-0.054957896,0.058068324,0.12002621,-0.03769622,0.050575748,0.018622003,0.030297711,0.044343732,0.029056123,0.08523821,0.03719579,0.01082587,0.06647962,-0.0167732,0.033456177,-0.037711263,0.027453383,-0.08642492,-0.03635855,0.046427988,0.019213533,-0.019293515,-0.003793216,-0.087889716,0.0026314883,-0.064936206,0.019702585,-0.057923026,-0.024916738,0.045555566,-0.055903558,0.003528886,-0.015398303,-0.03627434,0.033911306,0.007936012,-0.009024659,0.042346723,0.02586733,-0.06895721,0.011881378,-0.042081073,-0.0017410279,0.10114662,0.025536662,0.055462904,0.0931751,0.039262865,0.09648657,0.021682497,-0.059158035,0.064386174,0.02179746,0.069675975,0.09814948,-0.049579713,0.040574133,-0.0014386905,0.0006580248,-0.015594886,-0.01210745,0.075159565,-0.023804722,0.004500263,-0.033463147,-0.030901695,-0.08154023,0.0056278277,0.044111226,-0.07391072,0.029333014,0.009979009,-0.031049231,0.0142936045,0.048975557,0.07758012,-5.0633354e-08,-0.030447489,-0.05935425,0.0023571763,-0.061982006,0.029197372,-0.014701827,-5.8057223e-05,-0.05545784,-0.0040284265,-0.04632169,-0.018058702,0.031653374,-0.024850449,0.021646727,0.02491298,0.0029752762,-0.020296657,-0.00084919616,-0.013890663,-0.027170599,-0.08051307,-0.049391884,-0.11685093,-0.0034101566,0.044232413,-0.082610376,-0.029726041,0.041935466,0.10610963,-0.027367199,-0.05579675,0.0176106,-0.0144560225,0.019221345,0.025683695,-0.004956519,-0.07869063,-0.06409538,-0.05502476,0.03686296,0.060939696,-0.06875128,-0.07689167,-0.01930168,-0.006895195,-0.026310265,-0.022218628,0.049541418,-0.047696613,-0.011099565,0.10133668,0.004023077,0.05135598,-0.025030829,-0.12512375,0.07159622,-0.021985084,-0.05194543,-0.030203808,-0.008121382,-0.01925452,0.004029849,0.1331618,-0.050412465 +1.13.11.40,From the coral Pseudoplexaura porosa.,384,1.0,-0.055063974,0.06934945,-0.014169329,0.053160492,-0.06607109,-0.0843109,-0.025363335,-0.068525024,0.0026925926,-0.009501879,0.07614575,-0.10143503,-0.041114695,0.025879072,-0.059789706,0.058741163,0.0153587265,0.012338862,0.10097801,0.08370266,0.0650476,0.06883034,-0.030745365,0.04621152,-0.08433709,-0.027123844,-0.0684224,0.025726499,-0.00755549,-0.06019514,-0.025260577,0.050502993,-0.0030424877,-0.06263655,0.084013864,-0.001526128,0.007106572,-0.0054572774,0.099037476,0.07307367,-0.0015423959,-0.01904275,0.058454067,0.07845116,-0.042960756,-0.023109222,-0.039448515,0.027679143,0.066256285,0.00999158,-0.050660376,-0.043459643,-0.10305805,0.03217385,0.0021534597,0.04262595,0.020647258,-0.012029235,0.07960016,-0.09763715,0.088043384,0.022253305,-0.029134512,0.061547928,-0.04585113,-0.043538157,-0.049518388,-0.019109458,0.024207773,-0.007729448,0.031381287,0.008561225,0.047631215,-0.0028866432,-0.026606323,-0.004270392,0.059103053,-0.04355829,0.019555928,0.008231088,-0.024867084,0.003126733,-0.025220353,-0.052518792,0.10269723,-0.009431772,0.03242049,0.033286627,-0.04904159,-0.04958814,-0.0008644506,-0.0018939873,-0.09955757,-0.05900005,-0.12158098,-0.010128795,-0.03021758,0.026970733,0.07092648,0.03538597,0.063393325,-0.04932051,0.014537977,-0.0656527,0.0333754,0.011563186,-0.024745148,0.010916903,0.06749407,0.016760865,-0.12650706,0.04150905,-0.00018009562,0.008988822,-0.020459523,0.0923856,-0.053687617,0.022180118,0.056461524,-0.06413797,0.008655243,-0.08492313,-0.0070265806,0.0010371602,-0.015699698,0.01158602,-0.06554294,-4.136595e-34,0.054723177,-9.270866e-05,0.04219924,0.0042722914,0.0729217,-0.03711536,0.020829836,-0.11458871,-0.054121897,0.0217513,-0.10522401,-0.039008703,-0.037109416,0.0119910315,-0.071600474,0.014819501,-0.09735279,-0.0068782964,-0.07124865,-0.025807736,0.01207924,0.09617142,-0.045264423,-0.047622353,0.016455328,0.018549375,-0.016665312,-0.07766326,-0.01026665,0.058149826,0.040854204,-0.083848216,-0.015770819,-0.020698516,0.023393672,-0.029584719,0.041661408,-0.112837635,-0.01157057,0.024014594,0.053785153,0.023551177,0.07715306,0.060294487,0.03193009,0.020732624,0.0007953626,0.11115367,0.10289277,0.043926947,-0.004668148,-0.0650785,-0.08057811,-0.01373332,-0.07018323,0.02860135,-0.0036609503,-0.050614867,0.026326913,0.035060216,0.04441112,0.012340134,-0.008966164,-0.0511226,0.033458423,0.057702746,-0.03091631,-0.021261098,0.023301456,-0.07652102,-0.04258985,-0.09661276,0.029190896,-0.0410691,0.046800952,0.0064750086,0.066444,-0.04728829,-0.048452497,-0.0029068517,-0.06059586,0.047674954,-0.01411734,-0.025460854,-0.027021885,0.023067817,-0.02112378,0.0047754897,0.04243296,0.063942514,0.032459084,-0.0443064,-0.00088996027,-0.12002618,-0.08352486,2.8405633e-34,-0.019796936,-0.0013328879,0.0731621,-0.026713721,0.032500245,-0.027522745,-0.05135469,0.066119485,0.04666439,-0.02965969,-0.048337765,0.020163191,0.048333984,-0.03436026,0.030036677,0.06810369,0.08802927,0.03390982,-0.024405647,-0.04733205,-0.051409863,-0.010766198,-0.07337898,-0.0011110475,-0.01670171,0.06298799,0.03830289,0.02681347,0.015619568,-0.013315829,-0.08163438,0.020314058,-0.044496972,0.042270448,-0.092141464,-0.011083564,-0.08510671,0.016411262,-0.01966549,0.008998657,0.033049572,-0.027610658,-0.04132194,0.11560307,0.012550777,-0.02277312,0.042146493,0.02112958,-0.03329834,0.07681036,0.0187679,-0.0015807014,0.08872337,-0.019619144,-0.0021896395,-0.02536539,-0.04034235,-0.0070421854,0.067093834,0.02031743,0.06808618,0.031852864,-0.06922021,0.033104442,0.05124111,0.1154708,-0.010067551,0.04625923,-0.116711505,0.07093181,0.012928189,0.07322581,-0.123950705,-0.008469831,0.015230067,0.044560514,-0.14466771,-0.056181844,-0.0013823161,0.07766666,-0.0204262,-0.027097387,0.07331036,-0.010432566,0.03621642,0.043478962,-0.02554297,-0.037641127,0.03443417,0.00072727393,-0.06090268,0.014429176,-0.04350652,-0.013481651,0.044945985,-1.6057898e-08,0.08011879,0.056322105,0.042855855,-0.048442107,0.008806433,0.0018008385,0.027305556,0.035821974,0.040111538,-0.0066638035,0.016337054,0.01439838,0.07534387,-0.04636653,0.040965293,0.017820742,0.07967971,-0.03399802,-0.017960893,-0.055902254,-0.003116332,0.081556804,0.016688958,-0.017702026,-0.029108165,0.09836589,0.09293359,0.081246845,0.02966775,-0.038370047,0.0053599817,0.042236786,-0.08414785,-0.02777468,-0.0071723415,0.02332025,-0.075868085,0.015799684,-0.0441188,-0.07648056,0.030767564,0.037130333,0.0037674173,0.020438533,0.044617794,0.07261122,0.013086124,-0.024619946,0.06672653,0.0051169023,-0.006670956,-0.0079180375,-0.025586506,-0.026385417,-0.09486319,-0.021025594,0.008995838,0.043197654,-0.10294704,0.030378852,-0.019520687,-0.019733252,0.10026489,0.09404496 +1.13.11.42,"Acts on many substituted and unsubstituted indoleamines, including melatonin. Involved in the degradation of melatonin.",384,0.99999994,0.058186915,-0.005751545,0.08279309,0.062454343,0.011648321,0.10319438,0.03807978,-0.06695416,0.086654566,0.042762775,-0.049391612,-0.017848158,-0.048241295,0.08334265,0.028117552,0.09840192,-0.04370452,-0.016048202,-0.025568277,0.03662347,0.021207543,-0.014288994,0.02052475,0.021490987,0.009652972,0.038361955,0.017615616,-0.06231934,-0.014446747,-0.026796471,0.004141198,0.008350073,0.044678584,0.035925865,0.0063585513,0.047203504,0.0019223907,-0.03417728,0.06348098,-0.01175467,0.05026512,0.04335884,-0.021278549,-0.019973587,0.0074314796,0.0035707538,0.012729831,-0.08766722,-0.021691207,0.028637918,0.053214643,-0.045434073,-0.02487723,0.13261718,-0.0012828327,-6.452423e-05,-0.05130688,0.07515028,-0.033382665,0.008543192,-0.021921443,0.033061516,-0.028642029,-0.031408016,-0.03153415,-0.005915495,-0.00727258,-0.012767415,0.043960113,0.036215562,-0.020775074,-0.06555876,0.02995645,-0.08627872,0.042425234,0.017637584,0.012975581,-0.06294612,-0.049238753,-0.09496095,0.011873341,0.062480155,0.094243824,0.016961368,-0.007741916,-0.054962445,0.036519106,-0.042688355,0.04698145,0.031618822,0.007030529,-0.049760096,-0.07428441,-0.043250583,0.056913804,-0.046066213,-0.04250338,0.06511705,0.027177641,0.03720982,0.0076745804,0.021615142,-0.095767505,-0.0704645,-0.052155513,0.025258113,-0.06648664,-0.058758173,0.012912675,-0.0283728,-0.014454666,-0.0100203995,0.011747648,0.11489408,0.013873802,0.027288636,-0.015537414,0.07891709,0.0024477532,0.06315055,0.050209295,0.055890385,0.08454361,0.055521972,-0.11865198,0.008858215,-0.03441761,1.6909609e-34,0.03406312,-0.012111666,0.011923202,0.02499159,0.02106469,-0.024315793,-0.08376304,-0.010123802,0.033680033,-0.0646135,-0.021974923,0.023715982,0.020372074,0.0003900817,0.02294027,-0.053238526,-0.038156874,-0.025281463,0.10665046,-0.06476569,-0.082021266,0.13569127,-0.040385105,0.0009837389,-0.1007927,0.027084738,-0.015787268,0.1228914,-0.08786347,-0.022689098,0.06862175,0.020844733,-0.071562424,0.05393313,-0.0015445167,0.09860122,0.040402062,0.013856683,-0.01796044,0.017690478,-0.023862852,0.044089857,-0.038687304,-0.018262785,-0.00031727194,-0.06709814,-0.013899937,0.09533096,0.036172092,0.060637545,-0.014738438,-0.10054722,0.029265162,-0.056232218,-0.05148051,-0.00026993194,-0.007969234,-0.06121414,0.016084073,0.045421597,0.018254891,-0.053344388,-0.011926118,-0.0347172,0.015970562,-0.026790842,0.0033277113,-0.02825776,-0.13039322,-0.0348015,-0.014445101,0.0063903197,0.03409716,0.0603212,-0.021801716,-0.02488032,-0.00040862637,0.05825579,-0.033797376,0.0071386504,-0.048238203,-0.074194595,-0.05260188,0.016685162,-0.017636523,0.004122285,0.011469395,-0.059975542,0.031692695,0.019745085,-0.04530653,-0.07569416,-0.07291243,-0.017757867,0.028850926,-2.5748164e-33,0.018423289,-0.13456482,-0.03457772,6.6630324e-05,-0.03370077,0.030317752,-0.04840484,-0.050127108,-0.02898289,0.01987888,-0.024235874,-0.03718259,0.04298851,0.025342517,-0.016258573,-0.06176201,0.016447695,0.031057823,-0.06336158,0.00501187,-0.028489457,0.09959629,-0.08837702,0.030748323,0.07811501,0.03516433,-0.0055001867,0.07246979,0.057946354,0.031203367,-0.0376267,-0.02507329,-0.09999038,-0.027533477,0.090012856,0.11102331,0.039724458,0.0013849058,-0.1015802,-0.07164205,0.025997762,0.10143782,0.06372271,0.027416037,0.10160973,0.082063764,-0.05339117,0.04265973,-0.07272803,0.010236732,-0.01051847,-0.07926466,-0.04169972,-0.102007784,-0.068057,0.010500086,-0.01932928,-0.04096796,0.083954945,-0.0480742,0.0074218228,-0.022669608,0.03158133,-0.057155948,-0.029450683,-0.018573008,0.042913947,0.07349468,0.08501176,-0.055905674,0.14484785,-0.030389158,0.043126304,0.038105022,-0.09327148,-0.042739272,-0.0129412655,-0.035115995,0.0031840897,-0.13384804,0.007532703,-0.018405149,0.029900214,-0.05252512,-0.01896465,0.016396156,0.053036246,0.09190382,-0.027586179,-0.06043253,0.029021297,0.010292343,-0.033702116,0.08380067,-0.039604776,-2.6904914e-08,0.057662718,-0.049280584,0.004794374,0.0058048987,-0.009202269,0.015402975,0.053991053,0.051088482,-0.012855848,-0.07197831,-0.010233992,0.022895608,0.03431224,-0.03134902,-0.0448649,0.05962939,-0.039701294,0.074644424,-0.015044317,0.009171789,-0.085981004,-0.013895254,-0.010208729,0.012904323,0.0056386604,-0.04578566,0.001253803,0.08232373,-0.013323819,-0.069693685,0.122297674,0.09797989,0.024843635,-0.054951377,-0.030550236,0.029358149,0.04077885,-0.006127921,0.0029717132,0.04762908,-0.094294526,-0.024055324,-0.049767673,-0.0008369367,0.028020868,-0.05442956,0.017352482,-0.058269802,-0.016779918,0.01929346,0.013019078,0.04495692,0.006486688,0.045092903,-0.13087957,-0.05591198,0.031237818,-0.008445587,-0.00051330734,-0.09559804,0.0061032097,0.0010214726,0.05702685,-0.006888679 +1.13.11.43,An iron protein. The enzyme catalyses oxidative cleavage of the interphenyl double bond in the synthetic substrate and lignin-derived stilbenes. It is responsible for the degradation of a diarylpropane-type structure in lignin.,384,1.0,-0.01847519,-0.04068734,-0.0546042,0.14334075,0.14035165,0.013951057,0.030925767,0.000590289,0.027876817,-0.06473869,0.022086563,0.029366717,-0.10458604,0.0046759173,-0.023698205,0.013615813,-0.08226821,0.052726597,-0.045009885,0.03689674,0.005435022,-0.0041815885,0.009130491,-0.0042009894,-0.024551174,-0.047230147,0.06394594,-0.03596942,-0.012076929,-0.03559852,0.027502999,-0.033299264,0.023568561,-0.016863914,0.013524346,0.067027956,0.04767692,-0.11942786,-0.0052733887,-0.02620987,-0.009645498,-0.034255564,-0.021435184,-0.054072402,-0.02032187,0.018705187,0.07585317,-0.015789209,-0.0543458,0.055982288,-0.041724965,-0.05248422,-0.04229554,0.026799412,0.0045185243,0.04151417,0.013404025,-0.008430058,-0.03913063,0.030246453,0.023291424,-0.012714555,-0.05612547,-0.027776312,-0.04123065,-0.015517542,0.07040429,-0.030846693,0.005159017,-0.02720569,0.00195728,-0.028525181,-0.083969645,-0.024892855,0.023857854,0.009730481,0.009946268,-0.07915822,0.09263305,-0.019498318,-0.036793653,0.056655955,0.06584584,0.059068006,0.06590853,-0.030480085,0.010058448,-0.045671653,0.008078502,0.06462938,-0.025000041,0.049627244,0.01976917,0.014010587,-0.013120238,0.07204418,0.06670109,0.048059188,-0.010578504,0.03875674,-0.04097531,0.084288605,-0.04704999,-0.08215287,-0.011283809,0.055803932,-0.06435267,0.11238295,0.039358884,-0.0059724385,0.051078822,0.032541756,0.048558243,-0.043083455,0.02841334,0.06022787,0.0948463,-0.05074667,-0.030013965,0.050539155,0.04216184,0.08942648,0.049615294,0.08823506,-0.072423205,0.01256083,-0.09276308,1.10917865e-33,0.007667444,0.064306945,-0.059280187,0.024030855,-0.053456124,-0.04044789,-0.07254738,0.011563008,-0.03648696,0.045536764,-0.064542554,-0.087323025,0.010283942,-0.029341772,0.015520214,-0.03046432,-0.0089174,0.0346863,0.056738913,0.0023754209,0.019405365,0.059898537,0.011127344,-0.052086003,0.018388173,0.054070394,0.012794428,-0.015222761,-0.06644099,-0.0038250466,0.06719749,-0.08353307,-0.12110298,-0.02390098,0.08614874,-0.040761057,0.045341793,-0.018846525,-0.07243647,0.022557719,0.032689326,0.006502411,-0.042246114,-0.06519718,0.06625144,-0.0445935,-0.036949825,0.11927177,-0.026117153,-0.021512015,0.00015568086,-0.001310387,0.03689175,0.04419221,-0.07811209,-0.0075244424,-0.031040113,-0.04246558,0.02223891,0.03567969,0.08328125,0.010747092,-0.0011234117,0.06791658,0.019881846,-0.05368386,-0.02774196,0.052196775,0.047750402,0.04106726,-0.01980865,0.00457711,0.015852813,-0.01809396,-0.016102862,-0.09340564,-0.10435636,-0.033608202,0.10420327,0.08610687,-0.07314922,-0.033084203,-0.02849701,-0.06383904,-0.08458514,0.012590098,-0.021824224,-0.025674952,0.020678584,-0.072561555,-0.011974311,-0.0058096475,-0.021646522,-0.041690137,-0.016414477,-2.2003397e-33,0.031121217,-0.06723325,-0.063303135,-0.033719823,-0.061065715,-0.04407599,-0.0045916666,-0.051762816,-0.041389287,0.0071644275,0.06760303,-0.07721751,0.031260587,-0.0717924,0.055655565,0.03366989,-0.044652954,-0.013833479,0.07965493,0.019311868,-0.07523636,0.030545129,-0.0041290103,0.056421857,0.022098858,0.009104391,-0.07195492,0.0075474163,0.10130015,0.10436604,-0.0024702065,-0.017456472,0.066403545,-0.07898517,-0.014441288,0.013625328,-0.0411522,-0.02772736,0.068538316,-0.008072931,0.08616003,-0.042142734,-0.007164058,0.059802745,0.007008617,0.034858704,-0.12929259,0.032374218,0.023706215,-0.010000608,0.06660325,-0.03356777,-0.065550774,-0.0023935083,-0.04619357,0.016358092,0.032909993,0.052800134,-0.018251522,0.10091177,-0.029796088,0.0146390805,0.099510744,0.056150906,0.10158643,0.098899074,-0.041529097,0.07574731,0.031890925,-0.037630923,0.107220694,0.08525239,0.04993984,0.008599083,0.023235882,-0.06410291,0.023151368,0.07255794,-0.042092163,-0.02881607,-0.0060304347,-0.054451104,0.02342615,-0.044600155,-0.029522797,-0.09445147,0.0013273902,0.07956103,-0.01901362,-0.02547552,-0.05292892,-0.0677448,-0.071539365,0.060241714,-0.02920546,-3.333125e-08,-0.08728557,-0.008396041,-0.0066486504,-0.040324744,-0.0359911,-0.011418359,0.07967703,-0.034727093,-0.07050729,-0.0060586384,-0.0049635195,0.11133281,0.0055938456,0.000459268,0.046265308,-0.048663236,-0.025029985,0.065128066,-0.038957845,0.009886049,0.013492003,0.06202743,-0.029475586,-0.009174679,0.00068890955,-0.056948,-0.01990734,0.013673406,0.09817727,-0.045636907,0.0022289075,0.08983509,0.011562186,0.024340708,-0.04365729,0.044123102,-0.028971087,-0.042852167,-0.05959453,0.035687905,-0.0970551,0.013970115,-0.080958836,-0.054885227,0.0038076136,-0.026076617,0.013536074,0.016775597,0.016508242,0.08803929,0.05407457,0.008812319,0.029851485,-0.009966055,-0.07580326,0.034071345,0.02244614,-0.043593563,0.022205962,-0.075860046,0.024349444,-0.049274262,0.11624252,-0.10109924 +1.13.11.44,"Oleate and linolenate are also substrates, whereas stearate, elaidate, gamma-linolenate, arachidonate and icosapentaenate are not. This enzyme differs from lipoxygenase (EC 1.13.11.12) because it catalyses the formation of a hydroperoxide without affecting the double bonds of the substrate.",384,1.0,-0.035614274,-0.10086285,-0.073711626,0.015039211,0.0498515,0.022230184,-0.09418443,0.05777222,0.019244893,-0.07930052,0.015436006,-0.038900785,-0.067044415,-0.060184345,0.059329845,-0.042917203,0.02394652,-0.021987332,0.0239129,0.012636063,0.16117391,-0.03060373,0.014411721,-0.04590405,0.032403648,0.05886797,0.053382885,-0.041857406,-0.008489199,-0.075640805,0.03307054,-0.060896568,0.027836865,-0.03808346,-0.035065565,0.020242753,-0.023471551,-0.020393817,-0.0070649707,-0.014778887,0.04320253,-0.03150697,-0.03713735,-0.083854556,-0.008195598,-0.06570217,-0.03997897,-0.05357132,-0.081375614,-0.030285975,0.024724498,-0.13356054,-0.07428975,-0.0013609235,-0.026735127,0.0063630785,-0.0017959015,-0.06581224,-0.073492244,0.07456595,0.011922856,0.019243024,0.01095181,0.042822704,-0.06764203,-0.053407513,0.06620825,-0.05064566,-0.01609393,-0.10686483,-0.05421606,-0.023057163,-0.05769529,0.09337173,-0.021742446,0.030820386,0.014072037,-0.03849212,0.02800572,-0.05792048,0.012998187,0.005186249,-0.04862277,0.082082875,0.04668257,-0.004129439,0.031983074,0.0050051673,0.050602786,0.056517884,0.09225533,0.12147399,-0.017636355,0.06369711,-0.050228488,-0.041809324,0.085548714,0.0992567,-0.013985454,-0.023541,-0.00039947388,0.07877049,-0.06217554,-0.026575582,-0.025690537,0.021057773,-0.003800818,-0.055324323,-0.01301814,0.005081667,0.012174213,-0.0783332,0.069261566,0.03465027,-0.059035905,-0.003727857,-0.01231275,-0.089979984,-0.04446327,0.04218067,-0.023950065,-0.028399153,0.0756844,0.06113972,0.01748988,-0.0007511767,0.04202546,7.961861e-34,0.051683754,-0.025781587,-0.0564451,-0.049198356,-0.016003564,0.035555407,-0.04505367,0.040464688,-0.021988224,-0.036300205,-0.037240278,0.03427459,-0.001850935,0.08489054,0.043063007,0.039314196,0.032235097,0.11484169,0.061664738,0.0069648135,-0.014746888,0.03338508,-0.01157722,0.0029675532,0.027890392,-0.023095839,-0.056521777,-0.004211255,-0.038886916,0.0142079005,0.0079683205,-0.10508424,0.0035458112,0.04482372,0.013167104,0.0145589635,-0.016133483,-0.064969085,-0.06794809,-0.0019111854,0.0518844,0.042982735,0.043475848,0.015358166,0.023021445,-0.018200692,-0.0863518,0.08855247,0.10704033,0.03021016,-0.01951299,0.030611848,0.056477826,0.024097983,0.0036523559,0.07469334,-0.042405155,0.059163623,0.046750367,0.01044545,-0.036985178,0.14713071,-0.026477031,-0.002199772,0.01167944,0.04716279,-0.073527716,-0.024134958,-0.054488413,0.04690928,0.054330908,-0.049838882,0.061509423,0.09050163,0.060168482,-0.010835451,-0.041035973,0.03084058,0.041154608,-0.028404398,0.012534006,0.011656813,-0.02637499,-0.090720996,-0.09251006,0.06283712,-0.025529996,0.066309,0.020654967,0.085167825,0.03293317,0.01265476,-0.059012435,-0.020036401,-0.019891724,-2.7089545e-33,0.043993704,-0.070290685,-0.0030413182,-0.058116168,-0.0086790025,0.110719875,-0.04726149,0.0006838067,0.04635422,-0.02278745,0.07140617,-0.00026996332,0.017214013,-0.052750144,0.048012365,-0.0022443014,-0.034210134,0.035200678,0.012589735,-0.025598748,0.007089714,0.05572334,-0.031420164,0.050125502,0.054256883,-0.0058190203,-0.020305207,0.025006894,0.030301545,0.045769636,0.016530715,-0.006144997,0.005339639,-0.023028262,-0.051423047,0.06436446,0.016836349,0.007722926,-0.035381097,0.06278789,-0.075271234,0.018952895,0.03708666,-0.035292555,0.055283748,0.029036295,-0.11838757,-0.035765864,0.042807255,-0.04526597,0.018122396,-0.009443816,-0.004885404,0.017448694,-0.0035941321,0.01633231,-0.006091368,-0.0028070617,-0.057178807,-0.13234676,0.05466377,-0.037908852,0.0012074038,-0.06022139,-0.0029313753,0.0682592,-0.03374764,-0.026878279,-0.030350786,-0.02995398,-0.010019322,-0.045921188,-0.017053375,-0.026479157,-0.011837486,0.0033211717,-0.0056560184,-0.049403265,-0.08657718,-0.041984443,0.033753,0.05231681,0.050819576,-0.08396095,-0.086921945,0.055911925,-0.018480418,0.035865504,0.026613398,0.050500855,-0.06358447,-0.0059461333,-0.080634125,-0.008583217,0.042184316,-3.64504e-08,0.040912952,-0.01377896,0.07291447,-0.013436215,-0.08319243,-0.078786835,0.012100855,-0.055427343,0.06873357,-0.06971586,0.0036621362,0.12711506,0.021496942,0.02579066,0.08198568,0.015159726,-0.037070308,-0.012409491,-0.018515017,-0.0047001014,-0.050888997,-0.009391337,-0.013829916,-0.033828463,-0.0067084157,-0.02518882,0.021630092,0.05348698,-0.0054899435,0.012649393,0.011345308,0.0417016,0.06928647,0.007263943,0.03972552,-0.009015081,0.06317871,-0.07045918,-0.05944967,0.10535147,0.023499247,-0.09108636,-0.061642196,0.015350408,0.08622225,0.03471111,0.049223114,0.0358979,0.02546658,-0.05172406,-0.035296813,-0.036755476,-0.057920408,-0.06426972,-0.008000989,-0.03154639,-0.062320303,-0.044905044,0.00042381053,0.0077448785,0.05181483,-0.018585,0.26369086,0.008272921 +1.13.11.45,"The product (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate, is converted, more slowly, into (9Z,11E)-(13R)-13-hydroperoxyoctadeca-9,11-dienoate. The enzyme from the fungus Gaeumannomyces graminis requires Mn2+. It also acts on alpha-linolenate, whereas gamma-linolenate is a poor substrate. Oleate and arachidonate are not substrates.",384,0.99999994,-0.050405476,-0.029891582,-0.10106084,-0.08809197,0.12827602,-0.0056241765,0.0061762366,0.040960215,-0.05248518,-0.041049507,0.06303182,-0.008442928,-0.016372658,0.013089206,-0.08235225,-0.030677617,0.004561133,0.04107754,-0.012855722,0.055290807,0.12417284,0.010146157,0.02309227,-0.0875585,0.064756766,0.025203438,0.06947444,-0.04824139,0.00344331,-0.07859456,0.01565799,-0.0016973552,0.010641334,-0.054486915,0.024141522,0.046753254,-0.04155638,-0.026472647,-0.02266278,0.023083344,-0.0077693425,-0.0027077452,0.07816068,-0.026962524,-0.07488263,-0.019800039,-0.03258969,-0.030283334,-0.025945084,-0.03225935,-0.039039996,-0.11440745,-0.09048713,0.051283736,0.035063673,0.019443627,-0.10227126,-0.043222245,-0.09436557,0.051593203,0.047107797,0.013862475,-0.009267345,0.021961035,-0.018213715,0.004856965,0.018305881,-0.07334062,-0.05585625,-0.049302433,-0.037927143,0.002961475,-0.017202124,0.015907828,-0.016152777,0.045080453,0.014892129,-0.044167522,0.050490435,-0.007662534,-0.015681963,0.02992085,0.017827375,0.07762488,0.07367051,-0.02403497,0.05330973,0.08245456,0.037294585,0.073161684,0.09315674,0.13118955,-0.012832883,-0.010324914,-0.074550465,0.04709402,0.037815243,0.0547138,0.019852336,-0.006125027,0.013924653,0.045751713,0.0018352767,-0.091978215,-0.09566247,-0.0017878449,-0.026753707,0.06948477,0.023633968,0.07315689,0.032848775,-0.015466911,-0.033845536,-0.03827885,-0.056221563,0.0011604605,0.028995803,-0.06560625,-0.06972709,-0.029709382,-0.04492488,0.026055427,-0.017343264,0.004057383,-0.029231587,0.058156606,-0.010830754,1.1623218e-33,0.04633238,-0.025876759,-0.08228822,-0.027971556,0.0064945435,0.085230336,-0.066443324,0.024616666,-0.0008639764,-0.00526402,-0.10765022,-0.0296753,-0.020596242,0.031792916,-0.00091813295,0.0384756,0.023757068,0.01632872,0.07158199,0.03332335,0.021059282,0.03065132,-0.091172665,-0.0034968164,-0.0069585326,0.055055045,-0.017643731,0.018381575,0.019764997,-0.012211317,0.042274896,-0.1170341,-0.099752374,0.03020518,0.059379738,0.01189045,0.01795911,-0.00035891155,0.00056642474,-0.08032291,-0.011437023,0.050238833,0.0030170754,0.042662714,0.064668044,-0.019143132,0.039917767,0.08063964,0.11466137,-0.03451324,0.0025692694,-0.0039882804,0.056560148,0.058363993,-0.02554502,0.06604136,0.020234242,0.041412786,0.025200073,0.045682102,-0.01753006,0.122370146,0.043776974,0.07355226,0.043256413,0.026811484,-0.04340356,-0.08259593,0.0066075413,0.023085747,0.005085618,-0.08752275,0.05182186,0.057646792,0.030292733,-0.041936092,-0.0012517906,-0.0472755,0.019891305,0.030621195,0.05033181,-0.013428279,-0.014099301,-0.08467807,-0.08814335,0.07296353,-0.08252081,-0.006665437,0.018585157,0.06646766,0.09437265,-0.041910287,-0.022582132,0.014476724,-0.027793726,-2.4390654e-33,0.084209464,-0.11017815,0.0048116455,-0.059665907,-0.05586429,0.034324918,-0.036286835,-0.02182263,0.013332378,-0.026716718,0.08872903,0.009088776,0.025936002,-0.022953242,0.0010519279,-0.06335265,0.029811531,0.13603485,0.058923915,0.0023416681,0.03224753,0.14110562,-0.056156684,0.010114545,0.009274637,0.00046647163,0.047357053,0.07479934,0.035764765,0.059568755,-0.00860505,-0.058297202,-0.0449334,-0.072503835,-0.03803265,0.033773504,0.026156565,-0.025501719,-0.031179719,0.047191873,-0.008903241,-0.002656025,-0.018605858,0.041499242,0.009670685,0.037318677,-0.10226574,0.048356492,0.035378832,0.01619411,-0.015931146,-0.024347367,-0.036457196,-0.010335565,0.028959181,0.0021252462,-0.00513835,-0.015861956,-0.0157886,-0.052090205,0.02541412,-0.058583796,-0.04242508,-0.049663384,0.028478004,0.15080854,-0.04840222,0.03212646,-0.0069976216,-0.0040818737,-0.023248112,-0.014089219,-0.016836278,0.040570073,-0.037888642,-0.020932782,0.033700153,0.011207064,0.020223986,-0.095854715,0.05784491,0.025368987,0.039241143,-0.09491077,-0.027269108,-0.036532138,0.038357273,0.049676407,-0.0031358334,0.04008905,-0.0038648061,0.017387124,-0.048947856,0.04944766,0.011440684,-4.313416e-08,-0.03641041,-0.05233319,0.039915763,-0.12053108,-0.039601516,-0.049638867,0.04807971,-0.027922092,0.12122612,-0.061609972,0.023224989,0.14806335,-0.023881517,0.053611673,0.076858155,-0.0069417036,-0.0064110425,-0.016734827,-0.054676104,0.028500386,-0.052124463,-0.047334585,-0.0064603626,-0.03457315,-0.03782214,-0.049285498,0.050313596,0.09066118,0.0036736026,-0.0067680245,-0.03996177,0.07083915,0.008691886,-0.0575918,-0.046563163,0.030893115,-0.0129239885,-0.06112539,-0.010255306,-0.020282244,-0.02216935,-0.059347875,-0.07016258,0.017279867,-0.051669158,-0.07574951,-0.00860783,-0.0011697016,0.013844653,0.03602985,0.041525103,-0.029182537,-0.0060014487,-0.09433383,-0.030755246,-0.077656426,0.0033067819,-0.016109847,-0.077888906,0.03294137,-0.027029248,-0.038642958,0.18216261,-0.04000592 +1.13.11.46,Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.,384,1.0,0.03502224,-0.024287924,-0.11840972,0.00898535,0.07072004,-0.018051144,-0.054357696,0.05800301,0.012066196,-0.093745135,-0.006211956,0.012197909,0.027636448,0.039292872,-0.03001942,-0.11175057,-0.026708405,-0.024115974,-0.01809279,0.008453117,0.04979382,0.05838173,0.077238664,-0.050963584,-0.0383017,0.033077784,-0.014507596,0.0187697,0.036937702,-0.0668324,0.0252993,0.035154674,-0.02078941,-0.06891286,0.022131136,0.030642506,-0.053324547,0.010296922,0.103680894,-0.025267525,-0.01856873,-0.033757444,-0.043495487,0.0024248187,-0.019117141,0.0051257443,0.07583809,-0.05747082,0.032880347,0.11023039,-0.0047658123,0.03315145,-0.05090996,0.064731725,0.06449932,0.026887426,-0.0815076,-0.009202797,-0.008024554,-0.042670242,0.009462883,0.0011611483,0.0054958765,0.019865086,-0.09848469,-0.04310694,0.072275855,-0.061578903,0.04157182,0.047943436,-0.04877862,-0.028971829,0.009405297,0.031192945,0.014779909,0.024262594,0.024614101,-0.043628667,0.019673962,-0.02410558,0.03155952,0.011905613,0.02781799,0.12991905,0.011264102,0.015440043,0.044075444,-0.029090973,-0.036869828,0.08990105,0.07210988,0.008498244,0.0016577997,-0.05812082,0.006212971,-0.05413999,0.028782625,-0.033308063,-0.056280334,-0.014550895,-0.0833117,0.029774629,0.008175087,0.0021541151,-0.01443097,-0.043109268,-0.0131899025,0.039311152,-0.023341576,-0.0021133095,0.031537004,0.049070537,0.036721572,-0.04238344,-0.038289577,0.039285097,0.08100435,-0.046512417,-0.052074175,-0.025196126,0.07799777,0.043099772,-0.020548731,0.041225508,-0.03990981,-0.00882186,-0.04923557,7.061536e-34,0.016313393,0.107196845,0.012709753,-0.015976805,0.024659576,-0.011162914,-0.10326795,-0.08225383,0.0010426028,0.013417378,-0.07848608,-0.110198595,0.009611235,0.08067548,-0.03299224,-0.00021939969,-0.0019259977,-0.0026342764,0.018603966,-0.057426423,0.05656877,0.05909097,0.042855408,-0.049207654,0.0183674,0.10509697,-0.0007276796,0.060383208,0.05791456,-0.01338864,0.010310321,-0.062825754,-0.034654073,0.0071991747,0.09189382,-0.029711677,-0.041237537,-0.11032566,0.10374333,0.045621112,0.014136969,0.09223558,-0.01903057,-0.06804525,0.07088912,0.013699655,-0.035722338,0.112496145,0.022848401,0.0994508,0.059366684,-0.059854012,0.0077022393,-0.028829286,-0.056023512,0.020293087,-0.020542592,0.019012107,-0.021015888,0.06350018,-0.0063140644,0.011642168,0.0736498,-0.0019953463,0.11714557,0.019254435,-0.09294451,0.030773068,-0.025147699,-0.01567718,-0.04950682,-0.008929327,0.09713089,0.0053600036,0.07310484,-0.013364192,-0.057332948,-0.03577768,0.1047561,0.008291452,-0.045162577,0.020608926,-0.015146963,-0.044102706,-0.021457048,0.0075812875,-0.05727991,-0.059437018,0.01930917,0.044864666,-0.0038325503,-0.04740629,-0.04269632,-0.005366661,-0.04748778,-3.4715177e-33,0.04368013,-0.041362274,0.069489114,0.025198285,-0.016868599,0.055631626,-0.09090145,-0.110264115,0.029826714,0.046221483,0.03317268,-0.0031268967,-0.0005834233,-0.083267435,-0.018513659,-0.040790964,-0.010910841,0.08906629,0.0009517927,-0.0018892487,0.0010373949,-0.013516818,-0.008638702,-0.006772724,0.07078575,0.02995455,-0.015344566,0.014920645,0.041010175,0.05190094,-0.0046603475,0.0016202375,-0.105599135,-0.09710552,0.010073159,0.060739197,-0.01579394,0.055089343,-0.013418556,-0.04310535,0.021679929,0.018286979,0.038805816,0.028402321,0.03681637,-0.02757005,0.004486991,0.031239353,0.04380781,-0.022252448,-0.0021397045,-0.025842937,-0.024377158,0.015680678,0.01815869,0.04681976,0.10923315,0.012532987,0.08300917,-0.016659088,-0.03476284,-0.023653293,0.023132876,-0.031717952,-0.010569096,0.014951123,-0.023340054,0.07850185,0.11194622,0.008658509,0.05373339,-0.007169892,0.091635495,-0.029360158,0.002098437,0.06973218,-0.05882728,-0.09304856,-0.004703471,0.011522417,0.00092821673,0.017307164,-0.031465333,0.004283741,-0.061134078,-0.082884066,0.04829699,0.055234574,-0.009324115,-0.027977895,-0.0063248966,-0.03906437,-0.008810151,0.03609715,-0.008066075,-2.7193627e-08,0.008776129,-0.035074286,0.0107909525,-0.05123744,-0.0119465785,0.028893903,-0.0518784,-0.03580295,-0.044821274,-0.015006122,0.01776244,0.06158363,0.01853165,-0.07886932,-0.0005225711,0.08807052,-0.07664086,0.03733839,-0.03183661,-0.01593722,-0.15019162,-0.059649322,-0.13574484,0.04867553,0.050611526,-0.050610192,-0.012244355,0.011495978,-0.028195195,-0.01212628,0.061455462,0.020240039,-0.06984955,-0.045114186,-0.09714548,-0.08148585,-0.07719117,-0.020022836,0.061631598,-0.03289342,0.002987185,0.069335945,-0.044957615,0.046627507,-0.07560646,0.023829585,-0.03437944,-0.012109217,-0.12549604,-0.030048441,0.07603064,-0.033590015,0.03157028,-0.038708623,-0.10676833,0.08214322,-0.015887637,-0.0677625,0.04068837,-0.07671155,-0.12445261,-0.0119003495,0.16102551,-0.047618955 +1.13.11.47,"Does not contain a metal centre or organic cofactor. Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. The enzyme from Pseudomonas putida is highly specific for this substrate.",384,0.99999994,-0.014964996,-0.05602143,-0.091455884,0.01724072,0.08144145,0.02278166,-0.058121182,0.02737155,-0.0046333885,0.0041833017,0.070535295,-0.15338312,-0.07990754,0.043072984,0.023811515,0.0069361054,-0.07835661,-0.012197145,0.039037175,0.064586185,-0.008593026,0.05788504,-0.02759366,0.008606412,0.020148577,0.059820205,-0.031821877,-0.03439714,0.014341572,-0.0032770077,-0.058615554,-0.0031705017,0.010864098,-0.02812646,0.112865195,0.017461006,-0.029467477,-0.0049576713,0.065334894,-0.03535805,0.018471677,0.03631682,0.032181248,-0.018127808,-0.014043651,-0.020072572,0.04745279,-0.017081939,0.010866747,-0.05471171,-0.0054176874,-0.03521226,-0.0045353007,0.046123594,0.024120491,0.028609699,-0.0051709358,0.016009845,-0.0047290893,0.029672425,0.04266986,-0.014343353,0.033783194,0.045005534,0.052605126,-0.00069615437,0.027689936,-0.017815245,-0.028209053,-0.06066104,0.00075790775,-0.050488688,0.070736125,-0.013546528,0.025856733,0.0642637,0.028051384,-0.07840155,0.08308585,-0.023676218,-0.010424156,0.02750742,0.07798983,0.03080847,-0.045615666,0.010671886,0.055458304,-0.0020910087,-0.0451074,0.014880485,-0.055624735,0.07270565,-0.031480294,-0.12142804,-0.033889286,0.0563534,0.03562134,0.053199023,0.030675825,-0.02892311,0.0007581758,0.064348966,0.007903046,-0.13437977,-0.07194683,-0.0019106634,0.012851332,0.0775399,0.047395587,0.0421378,0.0073808804,0.05914759,0.029313067,-0.053757988,0.021399694,0.037873436,0.08840746,-0.08667849,-0.0035714442,-0.029647889,0.014570083,-0.11069917,-0.0151540255,0.05187663,-0.027834237,-0.05425485,-0.060491387,2.2285452e-33,0.027430475,0.0068291677,0.059938718,-0.03594474,0.02305649,-0.019201837,-0.07955291,-0.009999929,-0.011177514,-0.023770178,-0.04695742,-0.06012201,0.06446999,-0.032005273,-0.03019218,-0.07716519,-0.015805122,-0.006000356,0.050244786,-0.0140623,0.005776158,0.10330783,-0.06853826,0.00046543597,0.097549096,-0.020656314,0.0032600902,-0.05368057,-0.019184623,-0.026565326,-0.017824717,0.019015435,-0.08792735,-0.012365098,0.06518545,-0.03724416,-0.06877607,-0.0008169767,-0.08979438,-0.019243766,0.06058282,0.03393218,-0.08964412,-0.030734561,0.07616054,-0.14531386,-0.0835286,0.13599813,0.0070822043,0.06429799,0.034647983,-0.0035038637,-0.008415679,0.008473153,-0.06021157,0.03582462,0.008193161,0.0037891546,0.06369273,0.019018473,-0.02743975,0.043718074,-0.12754278,0.039915305,0.053278968,-0.021491418,-0.07475541,-0.008408941,0.02246927,0.051357135,-0.09298125,0.004780389,-0.018150294,-0.00089733483,-0.050357535,-0.03178388,-0.054295816,0.042687226,0.061933015,0.00503369,0.027626008,-0.0046356423,0.06132605,-0.09680068,-0.09211732,0.027143592,-0.011612463,0.008072958,-0.081037804,0.022832219,0.069398716,-0.103232,0.00013464973,0.0060676583,-0.0392772,-4.8728127e-33,0.05588903,-0.110830955,0.04826748,-0.13356714,-0.0051393406,0.029275907,-0.03923933,-0.06852633,0.023975043,-0.02776454,0.102234304,0.022087004,0.04036509,0.007475767,0.03599028,0.008200514,0.018325107,0.09257021,0.041024785,0.017083509,0.022908362,-0.023331206,-0.037251845,0.034979127,0.06570492,0.04798019,-0.0891929,0.070403725,0.054498658,0.05778277,-0.012152446,0.055750474,-0.009990414,0.004347171,0.011700925,-0.03825733,-0.04683431,-0.007785224,0.030654443,-0.003289154,-0.038522128,0.010379785,-0.059181783,0.12580797,0.014118443,0.041768566,-0.10114171,0.020627547,0.00962822,-0.0102596255,-0.017948037,-0.028555147,-0.090125844,-0.06836768,0.06090793,0.08515283,0.020779781,-0.025916487,-0.03603462,-0.061396874,-0.007377108,-0.010485255,-0.009498263,0.01729395,0.068232596,0.021387823,-0.023377018,0.08115126,-0.039596558,-0.03783859,0.03863596,0.114489965,-0.05323859,-0.042749293,-0.1267083,-0.01707933,0.036651075,-0.03608294,0.010380601,0.053425096,0.027643252,0.015607824,-0.0111739375,-0.039951023,0.010769915,-0.035157572,0.014610862,0.045958992,-0.018647468,0.022863865,-0.069515124,-0.017228384,0.033768013,0.07440081,0.034943134,-3.8748347e-08,0.011329948,-0.0051900926,0.073697634,-0.031763848,-0.04014483,0.07676091,0.036571287,-0.079506055,0.005348421,-0.039182648,-0.011318313,0.034748334,-0.029554741,-0.014235175,0.052693978,-0.053489193,-0.09697069,-0.069620214,-0.039909538,-0.039701104,-0.055740654,-0.11057253,-0.035427175,0.065621085,-0.05249077,-0.04366752,0.052752748,0.06953773,-0.04494469,0.020858804,-0.006993587,0.0053547956,-0.017905308,-0.027767168,-0.020334447,-0.014637702,0.05683268,-0.022498481,-0.07481611,0.012649022,0.018405734,-0.0011751284,-0.06377224,-0.00012237456,0.04757076,0.010112327,-0.028847238,0.04533621,0.030091235,-0.07516516,0.03753561,0.0021286865,-0.08535879,0.015361693,-0.08443898,0.036596797,0.02497975,0.038507603,-0.01820413,-0.0051535717,-0.005143074,0.011135395,0.21622825,0.021432454 +1.13.11.48,"Does not contain a metal centre or organic cofactor. Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. The enzyme from Arthrobacter sp. can also act on 3-hydroxy-4-oxoquinoline, forming N-formylanthranilate and CO (cf. EC 1.13.11.47, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase), but more slowly.",384,1.0,-0.052005734,-0.07139039,-0.10033387,0.016481575,0.07136855,0.00852918,-0.05079841,0.0067403936,0.008030746,0.0077631935,0.055907767,-0.12832221,-0.08845746,0.037766527,0.026762333,0.066344954,-0.08050466,-0.05404583,0.056131702,0.030401882,-0.06027132,-0.0025729232,-0.023842502,0.0013153875,0.01450055,0.030089518,-0.005889355,-0.048690114,-0.037977636,-0.026039066,0.006923577,-0.016036129,0.02032613,-0.014815238,0.081120215,0.045802098,-0.024693169,-0.041697126,0.07052554,0.044358227,0.019042037,0.072731845,0.0014777129,-0.009238028,0.01256394,0.0034587698,0.008806983,-0.011674628,0.034479517,0.026980951,-0.030382115,-0.054075707,-0.05802622,0.07248761,0.030005578,-0.027221978,-0.027009295,0.012403111,0.0016978848,0.05954566,0.028248833,0.045208424,0.07743303,0.05795432,0.020731017,-0.0028863542,0.007852987,-0.050288957,-0.036973268,-0.066363566,-0.024022209,-0.08330248,-0.0004933977,-0.0037373672,-0.015121437,0.044922102,-0.022208918,-0.076519355,0.08946895,-0.06053913,-0.04217179,0.021503793,0.06261115,0.045542542,-0.036742523,0.029630844,0.030861199,-0.053764205,0.03493567,0.04859362,-0.04267887,0.080541804,-0.025491199,-0.08463709,-0.019784387,0.013846653,0.08505153,0.08530245,0.022963721,-0.016074348,-0.030786257,0.057127643,-0.0075336667,-0.13223042,-0.08492286,-0.02128125,-0.0043959534,0.09408211,0.04933062,0.041088518,-0.029854633,0.037201144,0.06127614,-0.06390581,0.017854286,0.077891685,0.035959892,-0.08688959,0.005276168,0.0082996115,0.027044103,-0.07697603,0.028891455,0.011293036,-0.029870633,-0.012704116,-0.044196837,3.1385482e-33,0.066284716,0.018604094,0.08472008,0.011855878,0.0034139997,-0.011719398,-0.06751552,0.004663626,-0.03415808,-0.040318977,-0.016573755,-0.037079867,0.11796662,-0.021255234,-0.0454636,-0.033308215,-0.026187368,-0.0005340209,0.030222083,0.016503183,-0.00080160884,0.088666975,-0.06629442,0.014375873,0.005210759,0.026849506,-0.03701134,-0.023712397,-0.031689238,-0.014947846,-0.023282867,-0.002457797,-0.0892322,0.0034722586,0.037765432,-0.02491917,-0.08454545,-0.043142676,-0.117236376,-0.017345281,0.031656165,0.014294435,-0.06852798,-0.03495789,0.054708935,-0.10098373,-0.0888702,0.10485559,0.027969727,0.06557913,0.037087563,0.05649812,0.045963947,-0.0026058007,-0.04832289,0.06170708,-0.0060693854,-0.045806468,0.10289629,-0.015058454,-0.015063203,0.04600332,-0.079456314,0.023670807,0.05715057,-0.043498904,-0.060638133,-0.026646752,-0.0050532874,0.069285266,-0.043623954,-0.042345937,0.0027185308,-0.0026270202,0.012237164,0.0030764865,-0.043462884,-0.015587214,0.016973807,-0.031112993,-0.013972412,0.024204496,0.11941544,-0.088173516,-0.02711036,0.028338278,-0.029974686,-0.00022475829,-0.08702743,0.050835118,0.06027303,-0.077587426,-0.06833782,-0.029405184,-0.014883334,-5.2338757e-33,0.077267975,-0.09733747,-0.054156497,-0.1241983,-0.033843752,0.026438188,-0.006874704,-0.034855545,0.04201913,0.026648993,0.13631009,0.02743518,0.035475366,0.011346705,0.06802745,-0.0058165193,0.02255111,0.13085215,0.04401207,0.01419818,0.054153334,0.0018130554,-0.013727747,-0.0048645064,0.028415842,0.035075143,-0.10764539,0.049792696,0.09313426,0.043243375,-0.028192416,0.028447231,0.010690157,-0.0078063235,0.0070021106,-0.03591531,-0.07818665,-0.031840798,0.025132978,-0.0059446674,-0.00093979825,-0.052174926,-0.04608904,0.12081264,0.06030211,0.02034151,-0.0933003,0.053255774,-0.009329841,0.05910704,-0.017647626,-0.03643321,-0.07730004,-0.0857564,0.07115285,0.11268345,0.0062571103,-0.023375208,-0.024537597,-0.024804117,0.011471835,0.03598215,0.05334497,0.01800077,0.030202886,0.07797526,0.023835428,0.073031396,-0.0031894823,-0.036528736,0.06226817,0.11562964,-0.019767536,-0.015576459,-0.050963752,-0.049644135,0.026243264,-0.0041986005,-0.013939483,0.023363464,0.026808236,-0.0070057544,0.067084946,-0.048392687,-0.03150078,-0.0491351,-0.04093081,0.030303491,-0.000116024836,0.026992118,-0.04840849,-0.037593003,0.03318175,0.04853835,0.017241785,-4.9328982e-08,-0.03563811,0.041066602,0.1279028,-0.07464772,-0.009514691,0.07519045,0.0397339,-0.08025115,0.0020527034,-0.010134149,0.058372345,0.03822469,0.0070878346,-0.007715672,0.054969545,-0.052366264,-0.013046577,-0.02771339,-0.05594728,-0.03202714,-0.07233158,-0.07971228,-0.002135653,0.034253415,-0.04973249,-0.06980241,0.030424727,0.047960237,-0.06072214,0.012442864,-0.038958587,0.052093215,-0.011598713,-0.063615546,-0.05773135,-0.035018492,-0.014474041,-0.032209758,-0.045960996,0.02866815,-0.046295032,0.032179266,-0.08141539,0.018604266,0.06057775,0.010510899,-0.03817224,-0.022129042,-0.013283463,-0.042276677,0.041009404,-0.007299011,-0.05635323,-0.023537101,-0.082599245,0.062277317,0.0029083956,-0.02587855,-0.033014443,-0.07761933,-0.027153617,-0.00759205,0.21497563,0.020748565 +1.13.11.49,"Reaction occurs in the reverse direction in chlorate- and perchlorate-reducing bacteria. There is no activity when chlorite is replaced by hydrogen peroxide, perchlorate, chlorate or nitrite. The term 'chlorite dismutase' is misleading as the reaction does not involve dismutation/disproportionation. Contains iron and protoheme IX.",384,0.99999994,-0.004370022,0.027342243,0.018670483,0.012036992,0.07570262,0.036253124,0.0674517,0.036496114,0.03909684,0.014864194,-0.027101798,-0.03594827,-0.03167638,0.039384425,-0.060720414,0.04585644,-0.0053213034,0.030717285,-0.014014048,0.07594671,-0.013211977,0.004257935,-0.08800233,-0.02034098,-0.01856613,0.12719224,0.04664492,-0.034819525,0.029504105,-0.050723948,-0.009079278,0.035097186,0.12674591,-0.009586397,-0.016534198,0.05944733,-0.014434533,-0.06481729,-0.020957429,0.0069112363,-0.0258835,0.033990286,-0.09319404,-0.027339695,0.0066152737,0.020012513,0.05247611,-0.037900764,-0.0006520958,0.028748648,0.009901199,-0.01430333,-0.04729002,0.040525932,-0.008075653,-0.01753082,0.054881968,0.0001970785,-0.0016326271,-0.042640075,0.041163944,-0.078463435,-0.04955109,-0.05443552,0.013419263,-0.017346816,0.022445977,-0.011470592,0.017073292,-0.09594696,0.056943838,0.021132087,-0.022785798,-0.026157087,0.009597799,0.03720314,0.09327002,-0.04867904,-0.00925363,-0.012488514,-0.018603329,0.024410341,0.061718773,-0.0030799487,0.08542724,0.02259926,-0.09607837,-0.04263686,0.045700293,-0.01564972,-0.09729187,0.07501862,-0.026192203,-0.062575944,-0.08458513,0.071975425,-0.020125775,0.014846516,0.08153739,-0.038721878,-0.018017532,0.083640024,-0.1619604,-0.08275639,-0.0050096842,0.014656046,-0.004976464,0.06886269,0.005644756,0.012981255,0.0011919796,0.0076985806,0.0383935,-0.0067806123,0.013040052,0.024379099,0.08281913,-0.05202293,-0.08907811,0.012905214,-0.00026952615,-0.008465921,-0.017483959,0.018153531,-0.07184626,0.022990745,-0.042147685,4.165261e-33,-0.012615291,-0.0067933323,-0.04879379,-0.014506259,-0.038111962,-0.016372325,-0.07054002,-0.042687204,0.04604065,-0.12914865,0.038771927,-0.059319526,0.0040568677,-0.07205835,0.020188794,-0.03598731,0.051671106,-0.010782759,0.034503903,0.0019295627,-0.0015997108,0.09589095,-0.09223414,0.024677515,0.0019469017,0.034291595,0.032502867,-0.049258918,-0.021536093,-0.0586627,0.09073832,-0.044731002,-0.06524962,0.023144946,0.056134365,0.038813148,-0.016034946,0.0490072,-0.01969081,0.009608369,-0.050183747,0.019475002,-0.119404174,0.018645143,0.0728206,-0.09633396,0.020720383,0.09159202,0.046563692,-0.0101910895,0.0016772988,0.018401293,0.060608003,-0.04277051,-0.052748885,0.089882515,0.04197895,-0.039107166,0.07848573,0.065013684,0.062794626,0.09748768,-0.06082732,0.08676754,0.09123209,-0.037118614,-0.010986072,0.0073985,0.041299738,0.037355915,-0.06738265,-0.0059987325,0.07405525,0.08045179,-0.0059115477,-0.05428285,-0.05065311,-0.026938144,0.0884658,-0.0020413848,0.06455142,0.028501192,0.06955197,-0.076851904,-0.06909723,0.024920894,0.0039931475,-0.057191957,-0.002517283,-0.00570553,0.099678434,-0.04837055,-0.046671167,-0.08480969,0.008005215,-4.1065168e-33,0.0189365,-0.07700062,-0.036715742,0.0075681047,-0.07402399,0.0027738113,-0.12156513,-0.041296802,0.0051420643,0.025541313,0.0476102,-0.037841663,-0.057956807,-0.018109618,-0.02189153,0.035565708,0.041858356,0.10015353,-0.061374906,-0.05738073,-0.05071949,0.021167362,0.023418846,-0.024454389,0.013548171,-0.0128487265,0.027882965,-0.007964632,0.13489798,-0.03344831,-0.009947056,0.054402597,0.018942613,-0.051460568,0.05783766,-0.008184029,-0.070375256,-0.032738313,-0.0002656147,-0.026894985,0.023856321,-0.052028645,0.095308684,0.06798274,-0.019344166,0.019617083,-0.12069717,-0.006363194,0.033247124,-0.020638078,0.059909187,0.028421633,-0.07121462,-0.039311465,0.10696403,-0.03904865,0.04178162,-0.023807757,-0.010580515,-0.02058232,0.011663232,-0.02525392,0.041138917,-0.012302659,0.04861937,0.07330713,-0.032796834,0.087979496,0.09579205,-0.025399301,0.038940273,0.084132485,0.055169187,-0.11741211,-0.042882267,-0.0494204,0.014304475,0.0512233,-0.011235099,-0.016161129,-0.021318957,0.02290359,0.019102462,-0.04641034,-0.034829725,-0.06388582,-0.07917403,0.06976615,-0.051355846,-0.023374321,-0.049065676,-0.03274376,0.025504172,0.026944462,0.029471358,-3.9958454e-08,-0.049645845,0.001346123,0.06643289,0.010432514,-0.024025826,0.0031249388,0.027640035,-0.019972594,0.030149763,0.01802497,-0.08619698,0.043438826,0.046900246,-0.101214394,-0.01820381,0.050950382,0.051765963,-0.09304738,-0.007913646,0.022119636,-0.04261913,0.021817997,-0.047054738,0.096373126,0.008236314,0.005314884,0.043278757,-0.026628256,0.018405946,-0.039922323,0.0051687504,0.0021945415,-0.006434351,-0.013210284,0.029993245,-0.05458182,0.07133418,-0.04129639,-0.011138339,-0.036681775,-0.0068589295,0.020958722,-0.07193535,0.08408106,-0.06912386,-0.00034497393,0.017840577,-0.038592502,0.008284969,-0.078627214,0.08287345,-0.014049089,0.016765688,-0.010900368,-0.0790088,0.15541446,0.09034225,-0.06355275,0.023965005,-0.009064481,0.057209466,-0.04601143,0.07083748,0.04702755 +1.13.11.50,"An iron(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates.",384,1.0,-0.086049855,-0.052910853,-0.094874434,0.08027314,0.07052008,0.076933496,-0.049280103,0.0051679513,-0.0045372336,-0.03769698,-0.050465174,-0.008795865,0.008138984,0.010424689,-0.049700797,0.025234293,-0.035776667,0.012092877,-0.020672739,-0.030611442,0.029781992,-0.027425257,-0.060642995,-0.15164009,0.007857291,0.014518476,0.017290454,-0.021868257,-0.044206183,-0.07491103,-0.010828541,-0.048895862,0.028127557,-0.0208769,0.06393182,0.043866728,-0.00911298,-0.067056336,0.11626355,0.012973087,0.014327354,0.07019744,-0.0133237215,-0.02911593,-0.01238102,-0.060980253,0.017954603,-0.015186109,0.024606539,-0.0020870448,-0.037377615,0.013210838,-0.029715111,0.03571355,-0.024126792,-0.024794778,-0.02779335,-0.09719415,-0.028698718,0.01252911,0.08492125,-0.03045472,-0.03072091,-0.0048955926,-0.027131505,-0.04472691,0.07120712,-0.059759762,0.016652014,0.030226976,-0.07273469,-0.030140407,-0.096152395,0.037361354,0.07688564,0.0136680575,0.0016241306,-0.05150141,0.030062983,-0.04495657,-0.068302326,-0.038970787,0.043115284,0.07224853,8.368809e-05,-0.006269487,0.005300106,-0.04472126,0.03781685,0.09510655,0.012589606,0.019037372,0.07752709,-0.07672819,-0.030629069,0.0014535588,0.07137432,0.0022695982,0.014489618,0.027172364,-0.05098059,0.049918294,-0.036648013,-0.023464102,0.010361927,-0.041373212,0.016806085,0.11105351,0.04277954,0.013904727,-0.02508661,-0.04078514,0.011262139,-0.044265382,0.011563023,0.047261227,0.037334286,-0.015397891,-0.030015877,0.0425205,0.054546222,0.026481956,0.029545616,0.08014666,-0.012332708,0.02472944,-0.07334908,3.5240336e-33,0.014490297,0.055018242,0.04781125,-0.04606401,0.03683963,-0.023497358,-0.11532238,0.031408664,0.04416451,-0.020215988,-0.08328257,-0.04631858,0.01488248,-0.011581919,-0.03589176,-0.016938005,-0.06623203,-0.0072554043,0.051799264,0.022158056,0.001538572,0.033672977,0.060613587,0.034547985,0.024991708,0.02292565,0.033733908,0.07714702,-0.060578257,0.0141223585,0.013915056,-0.064994894,-0.1267666,-0.046303675,0.0646359,-0.015562656,-0.014952698,-0.008405541,-0.01994833,0.087666795,0.027007418,0.031147288,0.009413297,-0.014969854,0.046529274,-0.07399159,-0.036062203,0.12897895,-0.00911067,0.03603869,-0.028012002,0.0016756057,0.118910894,-0.023493879,-0.06769181,0.02570343,-0.051037,0.039312582,0.056536105,-0.008541381,0.07966487,0.01783481,0.019249573,0.07310432,-0.01758492,0.072936356,-0.0653519,-0.0046444777,0.03326379,0.048799507,-0.025681125,0.04777767,0.07212215,0.03649983,0.0912282,-0.042119827,-0.12140924,0.0015657089,0.08573034,-0.015083125,-0.04612911,-0.039390374,0.0055613024,-0.045892127,-0.06533571,-0.051016454,-0.028956044,-0.048382673,0.049448166,-0.020118559,0.040335048,0.032221776,-0.05081819,-0.0013551838,0.040922508,-4.8239434e-33,0.09871822,-0.054349173,0.048748843,-0.054217618,-0.09434477,0.0102391075,0.013737293,0.028113803,-0.009953027,0.034486614,0.10970617,-0.0038798975,-0.009261079,-0.07947737,-0.0025720417,-0.0044876854,0.0027173127,0.040665455,0.042618956,-0.018284794,-0.07579082,0.034584474,0.010613754,-0.018008677,0.010100138,0.009729055,-0.086646244,0.017389817,0.051489767,0.07763647,0.013235912,0.036868762,0.068826646,-0.0985968,-0.095476955,0.03884857,0.007341513,0.021648327,-0.004230036,0.02899444,0.081557594,-0.049571615,-0.0024152996,0.0956141,0.07778555,0.034322668,-0.07089154,0.032003198,0.011564067,-0.060083676,0.016205592,-0.06399974,-0.06618023,-0.020260684,0.04824065,0.11167964,0.049348515,0.029949037,-0.010855317,0.052993603,-0.06660029,-0.008143733,0.1097821,0.043211974,0.082470156,0.0797067,0.015935596,0.14941253,0.027444288,-0.038970295,0.018731756,0.03832728,0.05702997,-0.050601847,-0.0008789517,-0.02832182,-0.0023632592,0.005284449,-0.09626925,-0.017930765,-0.035433035,-0.065267764,-0.08238903,-0.03883656,-0.112127595,-0.058826916,0.006960857,0.010541638,-0.049140364,0.0008837979,-0.054567304,-0.0018247927,-0.05784275,0.01889774,-0.011161204,-3.8661554e-08,0.03796532,-0.012554304,0.07571156,-0.041745428,0.021928096,0.036910776,-0.015456505,0.0075391755,0.08020058,-0.05723385,-0.058601003,0.08407049,0.06631983,-0.019666446,0.010763463,0.010533986,-0.07133232,-0.011856308,0.008993205,0.021786682,-0.106176384,-0.009461263,-0.0014508844,0.02142441,0.01344013,-0.08183393,0.013587039,0.014696001,0.0075894156,-0.03776481,-0.05450205,0.07591209,-0.025597822,0.00021083678,-0.07335355,-0.05747886,-0.013211228,-0.100701354,0.016204648,0.045734126,-0.030014293,0.0912203,-0.1561981,-0.0007023865,0.09836108,-0.005422652,0.020259773,0.0237919,-0.058583606,-0.07097886,-0.012866659,0.038301896,-0.024650943,-0.019721495,-0.025851391,0.056609344,-0.027166583,-0.049402326,-0.033300906,0.03493134,0.0053837188,-0.03967475,0.12631357,-0.063471146 +1.13.11.51,"Requires iron(II). Acts on 9-cis-violaxanthin and 9'-cis-neoxanthin but not on the all-trans isomers [2,3]. In vitro, it will cleave 9-cis-zeaxanthin. Catalyses the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress. The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.14.14.137 [(+)-abscisic acid 8'-hydroxylase].",384,0.9999999,-0.08775465,-0.05704911,-0.14153343,-0.00031890816,0.09128865,0.0036616463,-0.045314174,0.05481436,0.009016418,-0.084336385,0.064555764,-0.089238584,0.008490412,-0.028175034,-0.03592051,0.019799367,-0.078733996,0.010695579,-0.04077667,-0.06432243,0.07872193,-0.0242769,-0.003097313,-0.021252107,0.03108419,-0.030556967,0.030902809,-0.04276833,0.02137305,-0.024124121,-0.10331572,-0.070695505,0.047898315,-0.06400327,0.039873462,0.06700935,-0.05403037,-0.05477449,0.035986446,0.0048583904,0.018297143,-0.043903727,-0.03625072,-0.05321257,-0.012023167,-0.054360792,0.040046472,0.003226139,-0.037822913,0.035714474,-0.032008115,0.018635603,0.0046369615,-0.0077614514,-0.04161866,-0.06765002,-0.052221537,0.0018282022,0.029856505,0.04710393,0.057089012,-0.050101526,0.019426918,-0.021155389,-0.020451402,-0.023899365,-0.017451694,-0.05194658,-0.006139923,-0.050556403,-0.03206839,-0.021820145,-0.049282737,-0.028310679,0.007027225,0.04012415,0.022516241,-0.03075708,-0.05241001,-0.008790992,0.052839722,0.02772654,0.0685959,0.07030887,0.058193248,-0.0007949427,0.011932453,0.06675378,-0.071505174,0.09765266,0.020398373,-0.012264833,0.022189979,0.012883169,-0.029154606,0.12263297,0.051794045,-0.07075388,-0.012648378,-0.092079945,-0.05226724,0.103903584,-0.042385474,-0.009815774,0.0229928,-0.048392057,-0.035870112,0.102330536,-0.046333253,-0.040244665,-0.0049011903,-0.040540945,0.039494775,-0.029866707,-0.02244707,0.09412643,0.019329552,-0.046813607,-0.025678616,0.043915607,-0.0064539807,0.0648742,0.0053868364,0.07477537,0.029659472,0.05934057,-0.086004965,2.8809908e-33,0.01993475,0.114621356,-0.07140317,-0.010701005,-0.032718796,-0.02490489,-0.11204656,-0.020833327,-0.039576333,-0.06346284,-0.04913032,-0.0762456,0.021668738,-0.044474494,-0.011541185,-0.050643567,0.036378823,-0.06654837,0.029566813,0.00012579355,0.020286283,0.034903545,-0.06893045,-0.0019402365,-0.0063231555,0.040791433,-0.019846201,0.03494702,-0.0072597023,-0.032490578,0.02169399,-0.04216354,-0.072290234,0.015760493,0.13973145,0.06300567,0.03284547,-0.03128198,-0.07674475,0.060637258,-0.018127838,0.09171903,-0.024065021,-0.09923317,0.12085058,-0.062382866,-0.039280944,0.07987113,0.11240782,0.049557213,8.457025e-05,0.111263104,0.09546647,-0.013595582,-0.07027896,-0.019166488,-0.01184549,-0.03964947,-0.017188966,0.05326408,0.007843729,-0.0053688325,-0.028728673,0.036186278,-0.0006955953,0.04105873,-0.11887682,-0.04107155,0.0110207535,0.04103062,-0.10519603,-0.052456386,0.067920096,-0.013875182,0.051331833,0.0012361448,-0.04126673,0.00081953045,0.009782013,0.029057669,0.0077985306,0.10692451,0.090662345,-0.0381484,0.01912526,0.010136607,-0.042308394,0.027337836,0.060939938,0.030455548,0.018285207,-0.054204386,-0.05450959,0.005020247,-0.031309295,-3.3875113e-33,0.0894098,-0.077383734,0.052716777,-0.03131431,0.01613394,0.08321529,-0.086650915,-0.07348947,-0.012215053,-0.018072488,0.06005084,0.06431286,-0.008189882,-0.026093796,0.024158083,0.030641988,0.018799452,0.120389186,0.017052127,-0.00011256778,-0.011620908,0.11631167,0.0024090605,0.04720625,0.027888397,0.012254801,0.047137503,0.014282935,0.0649985,0.041590605,-0.02225355,-0.0128002325,-0.06768317,0.019205505,0.024028817,0.031010242,-0.06100814,0.056752615,-0.021417018,0.09632212,-0.007536785,-0.06291612,-0.05622763,0.00076115853,0.029444408,0.037335373,-0.040960662,0.0006475471,-0.05668005,-0.017656084,0.05536177,-0.011087636,-0.005924191,0.034892675,0.09938422,-0.021489566,0.036443602,0.055662155,-0.0043646037,-0.013193209,-0.02807215,-0.0044106445,0.049413934,-0.07001758,0.04243424,0.05248142,0.020277843,0.08543058,-0.018193921,-0.022628423,0.08373599,0.047758233,0.026592804,-0.013815488,0.04461985,-0.02264608,-0.046702463,-0.033416986,-0.01838207,-0.020992972,0.011508172,0.030406598,0.028011011,-0.007103609,-0.03115561,-0.0058112186,0.01484662,0.06077643,-0.0033739184,-0.033100814,-0.013403358,-0.047046658,0.015626242,0.021650258,0.083898015,-4.652187e-08,-0.01766465,0.00992816,-0.002560866,-0.05592901,0.0054439376,-0.048288673,-0.036527026,-0.06348553,-0.01175561,-0.03120695,-0.065793216,0.022679532,0.087944485,0.0205257,-0.0062343283,-0.023290766,0.07948941,0.041924745,0.020425022,0.10755417,-0.14889114,-0.03144008,-0.11134571,-0.004156318,0.06266386,-0.08754247,0.04016077,-0.04464272,0.088654,0.053232297,0.05316967,-0.020926965,0.05881383,-0.030341934,-0.080140375,-0.0152798435,0.00027635987,-0.030242093,-0.0660314,-0.0052775335,0.04287932,-0.042565532,-0.030985635,0.021408446,-0.017989004,0.023872344,-0.026990026,0.02309901,-0.031168936,-0.008851845,0.02535683,-0.0649668,0.042899255,-0.024737801,-0.03997954,-0.0060322904,0.066555515,-0.03638394,0.007129469,0.010049082,0.016039703,0.057989616,0.18166775,-0.049240526 +1.13.12.1,A flavoprotein. Also acts on canavanine and homoarginine.,384,0.99999994,-0.03140793,-0.03642309,-0.15905017,0.05237886,-0.0031261973,0.051653884,0.06980019,0.03376513,0.06043953,-0.025656978,0.016831907,0.041514598,-0.037742104,0.045937046,-0.039690904,0.048923414,-0.027785907,-0.048948497,-0.04717412,-0.032511402,-0.018549915,0.050848346,0.03377173,-0.023834206,-0.032972876,0.017362604,0.007228665,-0.057582147,-0.008563065,-0.039983954,0.028473223,0.05047406,0.007087688,0.015756713,-0.057223734,0.0012229956,-0.038545657,-0.049525984,0.036182422,0.0015174736,0.032647617,-0.013078933,-0.004208111,0.024953416,0.04738076,-0.03054913,-0.017777363,0.11892044,0.04394551,0.07916172,-0.036765795,-0.06782676,-0.06219744,0.026889222,0.054793775,0.020389441,-0.09682987,-0.015298242,0.00021190742,0.051103186,-0.048469465,-0.018083828,0.07504435,-0.00090073486,0.053629715,-0.10884845,0.010111179,0.0086731445,0.0705869,-0.055368382,0.037219908,-0.037207056,-0.065394215,0.07320467,0.009850979,0.02250906,-0.028993519,0.016363593,0.05340487,-0.0083703585,0.057675846,-0.00801276,0.031017866,0.08404206,0.037686598,-0.05356293,-0.019738846,0.048910666,-0.027009452,0.062238168,-0.013766817,-0.014136451,0.01819697,0.020561729,-0.02657281,-0.0017762068,0.004314898,-0.03338915,-0.10983236,-0.0011146689,-0.051727142,-0.08158031,0.03452829,0.025412995,-0.06384673,0.025784327,-0.030285139,-0.03783083,-0.013547531,-0.06211575,-0.020578414,-0.06965341,0.051523287,-0.044638686,-0.0020445876,0.0155328065,0.059372492,0.0031985126,-0.047422953,-0.0051761353,-0.037017982,0.06690559,0.040185753,0.05249509,-0.047405437,0.054629356,-0.052277606,5.576113e-34,0.07659004,-0.016162483,0.013596259,0.05905136,0.024507033,0.04398189,0.018875474,0.004064047,0.054111764,-0.07044436,0.0036888528,-0.01722142,0.016473534,0.028542474,0.037440445,-0.019677661,-0.008372472,-0.02606799,0.04442794,-0.054427065,-0.070038654,0.12732573,-0.05084257,0.029372105,-0.04497003,-0.00045586625,-0.049017463,-0.025855444,0.029687522,0.007912558,-0.025920527,-0.04754817,-0.05043462,0.0076132766,-0.0037301565,0.03280768,-0.0013902738,-0.071469754,-0.12622617,0.06431543,-0.024024978,-0.058160737,-0.09924119,-0.0035912052,-0.014588664,-0.021250539,-0.10929012,0.045627113,-0.04520883,0.07717136,0.014789252,-0.060919967,0.12893334,0.030771691,-0.10263905,0.056058772,0.012523155,-0.003068577,0.029163845,0.020464092,-0.024387259,0.02914056,-0.017251013,0.017256157,-0.05360099,-0.029470881,-0.104425184,-0.080121145,-0.03442354,0.039437793,0.01771907,0.040418513,0.11405237,0.020747317,0.0073474613,0.007463251,-0.108198166,-0.00058995973,-0.011711931,0.007826434,-0.029050758,-0.076400906,0.07297498,0.031984784,-0.060896803,0.034652986,0.0059186136,-0.08155719,-0.015744576,-0.05888661,0.022113949,-0.008367555,-0.013431498,-0.02652704,0.07774761,-2.2654436e-33,0.039091945,-0.129563,-0.02246685,0.07560805,0.057699427,0.015767815,0.018407138,-0.011783019,-0.035772264,-0.03504357,-0.0049768263,-0.13350035,-0.004223845,-0.031738386,0.024017971,0.04051045,-0.03243604,0.112484135,-0.011801459,0.029269777,-0.09434918,-0.024486732,0.021441579,0.103015035,0.050764147,0.016222667,0.047580585,-0.10265874,-0.036227588,0.060063675,-0.017400613,0.013147959,-0.05934393,-0.078385085,0.0067646997,0.024692161,0.048775118,-0.04647675,-0.0384118,-0.044915024,-0.01897932,0.04065492,0.08518094,0.08725611,0.07825296,0.09266366,0.016314773,0.058292583,-0.018375928,0.015544895,0.00839965,0.02028945,0.017085485,0.12820546,0.037072703,-0.011534953,0.06725999,-0.008826224,0.02117876,0.028133279,0.00033678696,-0.11688608,-0.05213961,0.008604045,0.0815715,0.018885517,-0.009012464,0.046398662,0.03947325,-0.02553807,0.09919028,-0.07140124,0.036799718,0.075001776,-0.007544007,-0.013858729,-0.034752764,-0.00020536216,0.032083716,-0.01662288,-0.052649744,-0.06720764,0.018395655,0.0020999683,-0.013972932,-0.10695425,0.026463533,0.015221999,0.012313649,0.050435226,-0.035576917,0.013794845,-0.13867691,-0.0053346986,0.026546469,-2.259764e-08,0.033549458,-0.089370415,-0.026767822,-0.028509445,0.067202315,0.038087416,0.03258365,0.02249851,0.0748767,-0.023410717,-0.0066498006,0.06180932,-0.008754099,0.024616215,0.046229158,-0.026765859,0.06326773,0.028466597,-0.003245029,-0.027961921,-0.09451884,-0.019760262,0.011392471,-3.3832708e-05,-0.063715786,-0.09614208,0.006675859,0.07463246,0.11817133,-0.056818135,-0.013268698,0.025341883,-0.017763115,-0.07033432,-0.111161225,0.045808963,0.09215095,-0.05311636,0.028906679,0.056393415,-0.08198179,-0.0092645325,-0.029899474,-0.029014168,0.0346027,-0.045616303,0.06639616,-0.0058724973,-0.039271887,-0.05630457,-0.00030501015,0.04777591,0.026844924,0.029089237,-0.08784855,-0.013725365,-0.017899396,0.017942738,0.012415968,-0.09482831,-0.028539557,0.05485767,0.12913942,0.024946364 +1.13.12.2,A flavoprotein (FAD). Also acts on other diamino acids.,384,0.99999994,-0.039796554,-0.08540586,-0.108330145,0.006427189,0.09824625,-0.0052008634,0.04773255,0.052221317,0.05623764,-0.057893258,-0.0022547909,0.027968047,-0.057786193,0.017040621,-0.048852324,0.057243735,-0.015000112,-0.0051119593,-0.10727467,-0.04179549,0.0044063632,0.0007146908,0.025178064,-0.007506518,-0.034383465,0.039674092,0.07893402,-0.009490682,0.0053786095,-0.056417696,0.031527184,0.04655182,0.07075622,0.0059514386,-0.05830078,0.02114922,0.02288618,-0.044877533,0.01779504,-0.002168566,0.09106912,-0.0056263064,0.06467189,-0.016018456,0.071889326,-0.017222758,-0.040811248,0.117681175,0.038990323,0.048696846,-0.025864836,-0.048604887,-0.09031576,0.04216623,-0.021138418,0.07465584,-0.058725618,-0.038618002,-0.0162154,0.024826135,-0.024505584,-0.03076985,0.06745331,0.0010619003,0.051917642,-0.08251211,-0.024450338,-0.01352613,0.08662044,-0.046753693,0.055501595,-0.025514176,-0.04175,0.058591798,0.03263264,0.037242778,-0.05878159,-0.027737152,0.0764986,-0.030209685,0.05550685,0.04654974,0.0739253,0.08153447,0.03461966,-0.02893651,-0.028199222,-0.01678368,-0.06999553,0.049313817,-0.0025092328,-0.014253813,0.023585904,0.036525726,-0.08636734,0.009705177,0.03731355,-0.056043997,-0.094794944,-0.01331836,-0.050286464,0.012942349,0.02688708,-0.011089808,-0.0986465,-0.035726964,-0.039337505,0.029049154,-0.054024257,-0.05651619,0.011460753,-0.025906654,0.045344528,-0.066205576,-0.0073804744,0.006074182,0.028032232,-0.032238033,-0.064513326,-0.033613566,-0.034600217,0.033041432,0.045216203,0.054320015,-0.009483907,-0.008155745,-0.046036787,1.3502318e-33,0.06937584,-0.023739832,-0.0028587992,-0.0026085302,0.01667545,0.01654955,-0.05199769,0.02255912,0.08269473,-0.034729082,-0.060778018,-0.00037723008,0.031417392,-0.008366784,0.01539663,0.009431386,-0.027617991,-0.025822982,0.05816905,-0.06000061,0.024341999,0.115401536,-0.01692331,0.019091545,-0.010410335,0.01862478,-0.06252778,-0.014490882,0.02566693,0.025070474,-0.013853078,-0.03332384,-0.034761563,-0.0013312688,-0.03930209,0.05629044,-0.061539795,-0.0778933,-0.105030276,0.06961278,-0.038813185,-0.029194916,-0.10410893,-0.0316366,0.003963684,-0.07592572,-0.06433246,0.09640147,0.0002851948,0.050096128,0.02945808,-0.08261991,0.14422995,0.05802054,-0.076664925,-0.025953151,-0.01913524,-0.039560474,0.022911018,0.015453039,0.03975805,0.00873979,-0.054050084,0.08315838,-0.066267714,-0.0017003202,-0.08621405,-0.037687637,0.014811157,0.09086725,0.025041094,0.0057144123,0.09452975,0.00908192,0.00591775,-0.050030902,-0.058708236,-0.03894416,0.0034010874,0.048981436,-0.017343676,-0.055577006,0.042836305,0.017316245,-0.07178042,0.07007122,-0.01956259,-0.020998701,0.00076715846,-0.04283891,0.0065918644,-0.028655583,-0.00073608564,0.007465044,0.061476406,-1.902317e-33,0.046597414,-0.12910335,-0.018971326,0.070011824,0.05929733,-0.013528193,0.01087285,-0.010000304,0.015022325,-0.031081222,0.0014618954,-0.11404588,0.0019713494,0.018057982,0.050490107,0.071866706,-0.032564208,0.10109318,-0.026698207,0.036060467,-0.09537627,0.022533089,0.04724103,0.095208645,0.0440992,0.016560508,0.009052092,-0.0959711,-0.031632528,0.10883936,-0.0138066225,0.022994163,-0.08351563,-0.06899107,-0.025452174,0.028997231,0.005638677,-0.059690323,-0.030709304,-0.018233271,-0.019038562,0.051828988,0.084146604,0.07077446,0.07197572,0.07120293,-0.021368567,0.06323744,-0.026708933,-0.026201922,-0.004459841,0.020256516,0.009894031,0.09575989,0.03661947,0.0392915,0.042405255,0.04630265,0.020157829,0.030377723,-0.046399012,-0.15084027,-0.047878675,-0.007735005,0.05765923,0.05541157,0.0034838305,0.13737223,0.024402939,0.017401181,0.121405095,0.018099813,0.038210344,0.093500145,-0.0062318677,-0.02568681,-0.047611747,0.026598258,0.011297091,0.038885213,-0.0758954,-0.038510002,-0.02571211,-0.000105850224,-0.092992544,-0.08935778,-0.019032173,0.06572804,-0.017476639,0.044748902,-0.020181766,-0.012409239,-0.074728265,-0.0023352648,0.039770342,-2.1884755e-08,0.052500788,-0.091909274,0.020621363,-0.012284737,0.04114028,0.026162807,-0.01233986,0.030051246,0.024341064,-0.05239126,0.009178331,0.1110371,-0.0303783,0.00675828,0.033919696,-0.010836897,0.050983272,0.037818138,-0.02467716,-0.04975274,-0.06995456,0.012756388,-0.030709527,0.012867091,-0.0430595,-0.066774696,-0.007614787,0.023896229,0.05742733,-0.017848974,0.06193435,0.003110816,0.02907159,-0.07572139,-0.07295099,0.097766474,0.09341791,-0.050988764,-0.026230214,0.026198115,-0.07082932,-0.028500142,-0.046953853,-0.037100673,-0.003356968,-0.008270515,0.039396197,-0.031146558,-0.06318593,-0.033612993,0.0065952777,-0.038675062,0.039375793,0.02866082,-0.08747114,-0.036342025,-0.009269865,-0.065147266,0.029310547,-0.08011718,-0.018204188,0.064191125,0.13567017,0.03449175 +1.13.12.3,"The enzyme, studied from phytopathogenic bacteria such as Pseudomonas savastanoi, is involved in a pathway for the production of (indol-3-yl)acetate (IAA), the main auxin hormone in plants.",384,1.0,-0.07317552,-0.05010318,-0.12450432,0.03518943,0.03832044,0.108953804,-0.07342565,-0.0003175559,0.046791278,0.050223827,0.100716606,-0.05738157,-0.09562386,0.0055349623,-0.053307243,0.052496083,-0.089758985,0.0075076986,-0.013176896,-0.06458493,0.023511535,0.08161436,-0.03293457,-0.012831327,0.04193254,-0.030069094,0.0072986456,-0.01826342,-0.0019506079,-0.049671892,-0.0281084,0.023296652,0.12251445,-0.03609272,0.013686621,0.055814218,-0.015958603,-0.12360149,0.08799361,0.024159528,0.060062,-0.0046716863,-0.021643795,-0.064593546,-0.01616809,-7.7719014e-05,0.014857897,-0.015098876,0.124191724,-0.08074116,-0.032160282,-0.022088327,0.006711948,0.009060945,-0.02757194,-0.02466657,0.075491525,0.038172197,-0.04030637,0.101769954,0.029654881,0.014405579,-6.3534586e-05,-0.015518489,-0.013136082,-0.069263235,-0.01879312,-0.029198047,0.024409397,-0.03451686,-0.034316063,-0.0821635,-0.041843142,0.06275579,0.016549066,-0.0029006437,-0.06483198,-0.021733271,-0.006422215,-0.0681789,0.030166307,0.014429987,-0.0054049524,0.040103823,-0.03807968,-0.0027245441,0.0023629833,0.06525399,0.02652763,-0.008874554,0.015182803,-0.07123982,-0.033192266,-0.07646018,0.02432062,0.091406226,0.02659596,-0.09357039,0.034934092,-0.027047435,0.038792074,0.06718291,-0.0734242,-0.088675514,-0.067873016,0.042172804,-0.032141376,0.057794794,0.010148958,0.05032735,0.0025553417,-0.04152065,-0.013810942,-0.022009963,-0.026804758,0.060843255,0.011363255,-0.02962176,-0.030717274,0.022340432,0.00091698027,-0.019153852,0.043806635,0.14679027,0.018459268,0.021999937,-0.07816154,-1.2433827e-34,0.08289473,0.018805178,-0.061599437,-0.044566154,-0.026703468,-0.032597456,-0.058105964,-0.0013165845,0.07943659,-0.12015891,-0.05879592,-0.029803867,0.03236762,-0.04250542,-0.03477506,0.01888529,-0.044616397,-0.0060338476,0.06452247,0.057125036,-0.009182155,-0.02039623,-0.06342222,-0.0075254883,0.025099851,0.043646082,0.048217427,-0.020555431,0.013618843,-0.044110343,0.05967013,-0.04893934,-0.07775093,0.010058639,0.041305725,-0.0236208,-0.021757657,-0.0024639848,-0.020764362,0.07877254,0.04127248,0.098250814,0.0891013,0.021519678,0.052738428,0.035756845,-0.082344994,0.107105,0.076078914,0.08259365,-0.016676007,-0.011088167,0.11057536,-0.019524317,0.0057305642,-0.006102286,-0.030546362,0.005505097,-0.007166886,0.050492175,-0.019225972,0.0008477805,-0.054803573,0.058800485,-0.09093474,0.0388015,-0.094377235,-0.03316549,0.052958112,0.091143765,-0.097279556,-0.029876744,0.004119849,0.06561797,-0.021228703,-0.028823374,-0.042101078,0.036751527,-0.051975105,-0.0075705126,-0.030103793,0.005757887,0.008466134,0.015686559,-0.05200684,0.0039049205,-0.067871675,0.037301134,-0.002895123,-0.081901684,0.118474245,0.00873103,-0.018215843,0.092957884,-0.017886287,-1.6014206e-33,0.087829,-0.057254314,0.04372434,-0.12580958,-0.037200104,0.059988912,-0.027954293,0.023015898,0.0021320283,0.06194788,0.057585195,0.026252506,0.051814564,-0.0015711795,0.030971456,-0.059157554,0.016850436,0.062126465,-0.009182389,0.0609376,-0.07262057,0.051559232,0.04277272,-0.037638884,0.09004723,-0.017465265,-0.0538559,0.055867184,-0.055691235,0.06708689,0.07614873,-0.074715845,-0.12945004,-0.04505259,0.008235674,-0.010151378,-0.04343552,-0.017608935,-0.029791081,0.0070766564,0.06738145,0.069149025,0.010549266,0.038147956,0.02839594,0.033103492,-0.07454774,0.050963033,-0.033105265,-0.038554918,-0.024493823,-0.053068206,0.053532105,-0.033899628,-0.008000072,0.008407845,0.019363035,0.03877641,-0.035745263,-0.02117191,-0.015393958,-0.08746242,0.052882694,-0.026168438,-0.054152288,0.05726349,0.032050695,0.06297399,-0.004924497,0.004345331,0.07124147,0.011509207,0.024612581,0.10357743,-0.06380555,-0.02690724,-0.032595254,-0.08019634,-0.030887824,-0.031371836,-0.017558519,0.022067413,-0.06813427,-0.08436985,0.0043746633,0.036043517,-0.012126967,0.05756501,0.0028252876,0.046132907,-0.034007672,-0.0069829663,-0.05247502,0.028805027,0.012082731,-3.0755523e-08,0.013970681,-0.013641019,0.05121939,-0.021122044,0.009559628,-0.02001185,0.0036087625,0.03256514,0.011099168,-0.01953861,-0.07021882,0.07848767,0.011951785,0.02389662,0.051825896,0.02358255,0.02198807,0.0899164,-0.00459997,-0.044283044,-0.008538275,-0.022489592,-0.10891848,0.06310036,-0.017269894,-0.052858774,0.050716646,0.056646604,0.051404923,-0.044178016,0.06073786,0.04120407,0.039367694,-0.052266236,-0.08263802,0.014747552,0.0006040127,-0.019705392,-0.04124919,-0.018343335,0.014424332,0.0030033847,-0.093092516,-0.034490164,0.061360877,-0.0029615385,0.046377406,-0.035147216,0.02087334,-0.029680876,0.040434584,-0.07715099,0.045288473,-0.012421476,-0.060828004,-0.056149743,-0.020999217,-0.054500673,0.014231477,0.022750784,-0.014291525,0.035855737,0.17819315,0.028813161 +1.13.12.4,A flavoprotein (FMN).,384,1.0,-0.032478023,-0.05179858,-0.13370027,0.104683064,0.012068459,-0.0017250342,0.07882856,0.09061309,0.03566907,-0.07908727,0.029951362,0.036009923,-0.09061876,0.023842787,-0.11243062,-0.0014840491,-0.026581708,-0.04076453,-0.058442995,0.0078994455,-0.10094376,0.030740384,0.06847269,-0.024649855,-0.07463993,-0.02579874,0.00866155,-0.0039613545,-0.011395027,-0.01838179,0.10734743,0.075404376,0.058687795,0.044467833,-0.030367117,-0.018590461,-0.00011803854,-0.037540983,0.016161278,0.017737206,0.051187176,-0.049844746,0.0464887,-0.03263261,0.05681386,-0.022497332,-0.045473088,0.09122509,0.04574022,0.0928817,-0.030805469,-0.05418055,-0.079523414,0.07582417,0.054068547,0.0031989994,-0.054437216,-0.036465265,-0.042837996,0.08668061,-0.044175263,0.029741524,0.043668725,-0.020028906,0.07832068,-0.06502889,-0.037002347,-0.028821452,0.08690994,0.041425783,0.047731034,0.0041383025,-0.07954754,0.042886104,0.00017102087,0.06421507,-0.026586568,0.014902445,0.06609365,0.01566831,0.07088899,0.008283497,0.032013036,0.06821586,0.019018183,-0.06440397,-0.032013487,0.02226496,-0.051459502,0.08374453,-0.058850396,0.043978866,0.020078534,-0.011874117,-0.032488678,0.043991975,0.02480479,-0.020194514,-0.10990464,0.07156895,-0.044114336,-0.060478102,0.048465896,-0.0067846677,-0.08943393,-0.03166091,0.023670886,-0.014387124,0.033599257,-0.0850211,0.0051401816,0.007989691,0.020751959,-0.09695264,0.013776301,0.008630331,-0.016768532,-0.01655476,0.014374001,0.051366694,-0.053508047,0.083449066,-0.0034076737,0.07690282,0.024218459,-0.0023440302,-0.112727016,-1.9186883e-33,0.03852834,0.019891744,0.046163093,0.039754275,0.0022122094,0.018996533,0.04035592,-0.02211705,0.031606216,-0.0347224,-0.07180371,0.0122316275,-0.019900158,-0.045158464,0.037821498,-0.0020732796,-0.02968479,-0.03379632,0.027989564,-0.04273078,0.011760624,0.00035117535,0.0021589133,0.0055074696,-0.0013049658,-0.0013194898,-0.07552234,-0.035060633,0.021296833,0.026747014,-0.040911134,-0.00034930828,0.006692563,-0.00040305042,-0.00060928566,-0.033922307,-0.021979408,-0.06947102,-0.09944165,0.080656566,0.009878658,-0.03139382,-0.06179944,0.042605925,0.020570265,0.022809248,-0.092422545,0.080705605,-0.027389307,0.06775612,0.057683945,-0.048154116,0.10301367,0.041856654,-0.05734651,0.008119861,-0.005858283,0.024239706,0.0073395255,0.0042485255,0.018779658,0.0361811,-0.057235107,0.033917088,-0.050236404,-0.03528599,-0.023148492,-0.019809144,0.028765416,0.017232815,0.07218966,-0.002723962,0.09685423,0.015676921,0.016317908,0.0022662408,-0.05820639,-0.014613427,-0.040661894,0.031282317,-0.026203461,-0.026515247,-0.016242258,-0.00939285,-0.07652859,0.038655963,-0.0063172025,-0.029923445,-0.012393217,-0.040152647,0.037135005,-0.026183374,-0.02416439,-0.054804165,0.009824763,1.1281629e-33,-0.04028331,-0.09180406,-0.09146443,0.084735826,0.021626778,-0.013784433,-0.02003762,-0.02396626,-0.01038554,0.021873843,0.030013118,-0.1429387,0.019305548,-0.04468063,0.022724254,0.06710919,-0.027860332,0.09689544,0.061932225,0.032016605,-0.09994565,-0.035143442,0.046241775,0.13037029,0.028258797,0.02460241,0.09233267,-0.040578514,-0.027514566,0.061942395,-0.06275373,0.010805331,-0.0537398,-0.069762625,0.022303319,0.027658273,0.02064955,-0.08221571,-0.00315379,-0.026435276,-0.01207723,0.03567952,0.065991,0.08751679,0.033791218,0.09215163,0.0044160555,0.07492928,0.06613222,0.017597968,-0.020362414,0.031105943,-0.023372646,0.108297385,-0.000650131,-0.00044539678,0.056748327,0.05376454,0.006783218,0.024704996,-0.0011306674,-0.12745833,-0.04617474,0.0012318956,0.04472942,0.061008062,0.041625567,0.08365091,0.022285942,-0.022474643,0.091585934,-0.042432804,0.05706201,0.043919753,0.0005173123,0.01581554,-0.0062559135,0.09307378,-0.012809298,0.010322789,-0.03610541,-0.06908507,-0.020006813,-0.06258574,-0.0016009465,-0.09212458,0.02650021,0.0148678105,0.014178474,0.037363753,0.01767256,0.04253881,-0.09963732,-0.088668644,-0.025291463,-1.7478245e-08,0.03698026,-0.098238304,-0.046438336,-0.027305461,0.094271585,0.02195522,-0.0060105445,0.008022498,-0.034563277,0.030605989,-0.021566773,0.06949981,-0.032453623,-0.01904091,0.04430776,-0.05992992,0.065974236,0.048647195,-0.023735488,-0.042773675,-0.063094325,0.033100907,-0.019003958,-0.014941031,-0.08194262,-0.037103478,0.0030725559,0.0118781645,0.09512537,-0.04446524,0.039923783,0.05020535,-0.012346734,-0.057177357,-0.16712473,0.009163928,0.05032497,-0.04586911,-0.04699767,0.030583449,-0.12796594,-0.013004693,-0.008857267,-0.05870428,-0.034531265,-0.04312602,0.061448682,0.008672175,0.0070219054,-0.040545963,-0.0064151166,0.0040601213,-0.011420789,0.031102978,-0.047946263,-0.030640777,0.038545787,0.012308286,-0.024769237,-0.07554625,-0.052430492,0.07297109,0.11289945,0.05876168 +1.13.12.5,"This enzyme has been studied from the soft coral Renilla reniformis. Before the reaction occurs the substrate is sequestered by a coelenterazine-binding protein. Elevation in the concentration of calcium ions releases the substrate, which then interacts with the luciferase. Upon binding the substrate, the enzyme catalyses an oxygenation, producing a very short-lived hydroperoxide that cyclizes into a dioxetanone structure, which collapses, releasing a CO2 molecule. The spontaneous breakdown of the dioxetanone releases the energy (about 50 kcal/mole) that is necessary to generate the excited state of the coelenteramide product, which is the singlet form of the monoanion. In vivo the product undergoes the process of nonradiative energy transfer to an accessory protein, a green fluorescent protein (GFP), which results in green bioluminescence. In vitro, in the absence of GFP, the product emits blue light.",384,0.99999994,-0.06390554,-0.058807846,-0.026282463,0.032473557,0.09252567,-0.10807232,-0.04214556,0.07227378,0.03713419,0.018420894,0.055540226,-0.12138965,-0.08282428,0.09675849,-0.040398605,0.07423042,-0.0659791,0.04374055,-0.025882557,0.04786106,0.09873511,-0.031721268,-0.07463194,0.028161295,-0.06161639,0.011039954,0.0034269395,-0.010482494,0.033749573,-0.028818972,0.01914433,-0.053800825,0.055622764,-0.050993197,0.034089763,0.07169518,-0.020426843,-0.06647847,-0.019890506,0.036918744,-0.02055243,-0.013514314,-0.0011425043,0.026491597,-0.012074424,-0.061084267,0.032279246,-0.03213128,0.023233706,-0.03943801,0.025529815,-0.06352968,-0.051472016,0.05156599,-0.00166544,0.057545513,-0.053440522,-0.043759923,0.07703052,-0.0829203,0.040300794,0.0076463604,0.020163203,0.024838574,-0.0010502058,-0.0194571,-0.032030135,-0.040826537,-0.052277535,-0.0889839,-0.024338672,-0.06374367,0.047574587,-0.04662096,-0.044587646,0.0626007,0.00648003,-0.019406203,0.010355315,0.054273583,0.116194114,-0.023455342,0.029927587,0.053643208,0.1618894,0.074796215,0.059254795,0.04023689,-0.011222284,0.033306353,-0.040919166,0.066123866,-0.043760158,-0.0049608583,-0.1363611,0.017415002,0.055763595,0.04471265,0.0014070097,0.0037052303,0.001957769,0.0026896696,0.00940775,-0.08081469,-0.047865625,-0.022183292,0.08333274,0.09734931,0.059349068,0.04933349,-0.048579995,0.07538461,0.0067339484,0.01511377,-0.01558201,0.14874794,-0.036633704,0.003585782,-0.04426859,0.06377604,0.020606542,-0.017920122,-0.0073194867,-0.009035547,-0.00932622,0.033334993,-0.05764452,2.4627097e-33,0.06558811,0.026022341,-0.05240604,0.04117671,0.03525419,-0.078750126,-0.04412069,-0.04448237,-0.13875851,-0.040561218,0.008098148,0.008689295,0.042525202,0.08345203,-0.036961503,-0.052985266,0.018467443,-0.039525032,0.021404676,-0.06263512,0.00883584,0.03603184,-0.038518377,0.050647415,0.015937,-0.014978697,-0.08960975,0.04668061,0.078043886,-0.010632847,-0.06018525,-0.07446258,-0.06291137,0.01806314,0.061399527,-0.0051259706,0.010640809,-0.03974202,-0.06983053,0.007286537,0.023470227,0.020063283,-0.037515894,0.0025359264,0.06471943,-0.09179039,-0.03039793,0.14096786,0.06454759,0.030031618,-0.0057583144,-0.046856456,-0.010456966,0.005770466,-0.04263597,0.03922891,-0.009548945,-0.07977418,-0.0031292778,-0.028730845,-0.05345556,0.01970298,-0.028093686,0.040216602,-0.021857983,0.08312832,-0.083711825,-0.015873821,0.020494385,-0.026555853,-0.05214499,-0.029161964,0.005417832,-0.056507535,0.041628037,0.033380874,0.052255902,-0.0027421599,0.01479927,0.037670407,-0.027353233,0.027960606,0.02366814,-0.038475294,-0.040000405,-0.0027193346,0.026507737,-0.010955964,0.0084011825,0.050068807,0.09605456,-0.10314879,-0.00066319533,-0.09090092,-0.021512626,-2.3157362e-33,0.017406538,-0.033110414,0.041373234,-0.040192265,0.03661666,0.057232175,-0.034922644,-0.0008463338,0.029152136,-0.09799976,0.03790854,0.0628443,-0.032809626,-0.035709966,-0.023489118,0.06969618,0.053973015,0.059853837,0.018773867,-0.019672198,0.002501243,0.083260186,0.003087997,-0.02653221,0.018189998,0.06175161,0.038872942,0.031916294,0.01636161,0.048265576,-0.056508783,0.044550445,-0.03757283,0.06750049,0.0034654674,0.058767863,-0.044447143,-0.029653143,-0.019942943,0.030032333,-0.0774062,-0.025953999,-0.026905367,0.078895286,0.010174497,0.059126094,-0.03489036,-0.0040668603,-0.047878433,0.031120466,-0.0022948333,0.012663723,-0.075450264,0.0304536,-0.001448491,0.0039888974,0.047947746,0.06780532,0.046186145,-0.03290853,0.03820693,-0.067883,-0.062115584,0.0069405143,0.012043801,0.053027615,-0.022115523,0.056021437,0.047670018,0.033454962,0.064419344,0.06500478,0.019900758,-0.0036260837,-0.0069441176,-0.013795106,-0.077548906,-0.13283275,-0.05910637,-0.0068195714,-0.061333086,0.026584525,0.044441693,-0.11598363,-0.021798026,-0.074158125,0.01681711,0.02110482,-0.044013944,-0.04775745,-0.021540672,-0.046145625,-0.0027274473,0.08269861,0.15543167,-4.991193e-08,0.0014291371,-0.041829403,0.003633944,-0.039443485,0.02624563,0.034574725,0.023605285,-0.04567003,0.015931914,-0.0037311525,0.008233916,0.042080175,0.034779206,-0.0010504855,0.071599685,0.017141396,0.050050158,-0.002886732,-0.042679474,-0.014979897,-0.04438684,0.03143246,-0.04246118,0.0020802622,-0.03398799,-0.0267337,0.030424966,0.06462494,-0.06963864,-0.011873795,0.058585446,0.07517392,0.025897624,-0.041894984,-0.0976586,0.015875706,-0.036143485,-0.029244775,-0.09067444,0.017341308,0.027476378,0.0028860613,-0.07246317,0.031034421,-0.03360215,0.02485843,0.02190267,0.014381905,0.0354308,0.048471525,0.085666336,-0.06260748,-0.060375113,-0.06549983,-0.08531346,-0.020042997,0.0033623406,0.089695476,-0.06982619,-0.04197207,-0.024961056,0.001376332,0.17547947,-0.0455453 +1.13.12.6,"Cypridina is a bioluminescent crustacea. The luciferins (and presumably the luciferases, since they cross-react) of some luminous fish (e.g. Apogon, Parapriacanthus, Porichthys) are apparently similar. The enzyme may be assayed by measurement of light emission.",384,0.99999994,-0.035666775,0.0068947165,-0.084951065,-0.0329026,-0.008145229,-0.01490154,-0.002586114,0.039365347,0.038944367,-0.022003997,0.037397746,-0.13163233,-0.010833452,0.05732706,-0.07941367,-0.0023795115,0.018485785,0.008675294,-0.022449909,0.029473571,0.007150535,0.03181641,-0.057124835,0.036005076,-0.0610731,0.10279552,-0.037771266,0.07297508,-0.03304272,0.02061933,0.009363609,0.041009497,-0.003973122,0.012763935,0.06004628,0.022262447,-0.012441987,-0.009033963,0.055395808,0.10099582,0.03392552,-0.034438558,-0.021816665,0.013320817,-0.0702065,-0.045447707,-0.029193996,-0.057178818,0.005151283,-0.102392375,0.011258325,-0.09311254,-0.004615177,0.090663046,-0.014245745,0.031071372,-0.08979762,-0.1072645,0.033623952,-0.06216647,0.005388769,0.06902659,-0.0057216007,0.019026084,0.0010366552,0.03171782,-0.023322266,-0.091038406,-0.041881092,-0.09326618,-0.023361193,-0.018373271,-0.00113341,-0.006378897,-0.050871745,0.016619492,0.02581284,-0.037322238,-0.08676851,-0.041986648,0.074603975,-0.032319136,-0.02876997,0.05469991,0.100660704,0.07684697,0.050216883,0.04642655,-0.08750069,0.03190011,0.027048588,0.04341164,-0.07754575,-0.034897704,-0.08181303,0.03521442,-0.014106939,-0.05491605,0.035263985,0.030592311,0.016323643,-0.076152846,-0.005967627,-0.07613334,-0.025112174,-0.053385783,0.048590537,0.10634912,0.08951745,-0.0012335068,-0.031581692,-0.028507777,-0.027766675,-0.009819037,0.030559229,0.08443214,-0.046713825,0.06921128,-0.025301911,-0.01302529,0.06805326,0.04454323,0.067927524,0.06736407,0.037851572,0.029272884,-0.15948357,-3.1786352e-34,0.10209542,0.01214946,0.037537504,-0.015386667,0.030416781,-0.012676991,-0.015622446,0.02228088,-0.0031356378,-0.08908808,-0.07235469,0.077899955,-0.015869386,-0.0066113463,-0.005865795,0.038950827,-0.029678538,-0.08163226,0.01027558,-0.029559111,0.045579,0.017851995,0.05138425,-0.037456937,-0.014262555,0.01786377,-0.075158425,-0.0066623697,-0.0058708573,0.025522534,-0.03273433,-0.043036025,-0.034214128,0.053438928,0.06403238,0.008884684,0.033765607,-0.06369728,-0.03093282,-0.05898727,-0.014934072,-0.04227693,0.035075728,-0.0031572815,0.06491484,-0.031418607,-0.0762349,0.06867859,0.047977548,0.04145243,0.064921744,-0.056248017,0.051673286,0.02004021,-0.12531278,0.082211256,-0.033326074,0.011372817,-0.018604677,-0.011138513,-0.0026439414,0.07873269,-0.027095113,-0.016034788,0.016969752,-0.008697918,-0.024631372,0.06952685,-0.036915205,0.06500441,-0.06919264,0.009024088,0.03666876,0.030357605,0.051186807,-0.05202635,0.011759738,-0.025194537,-0.058876045,0.06527253,-0.032152265,-0.01992619,0.047582414,-0.04029256,-0.10901545,0.052839343,0.10960433,-0.0001430324,-0.020017479,-0.0015197829,0.03329615,-0.023618057,-0.020682905,-0.04926579,-0.04757079,-1.04478875e-33,0.036445886,-0.052785847,0.0020969037,0.026099877,0.06654903,-0.01122998,-0.019808372,0.023602918,-0.030201714,-0.016587483,0.014004137,0.029406475,-0.017671922,-0.06394571,0.006502376,-0.017396847,0.015932798,0.05952716,0.045560393,-0.05381609,-0.13540179,-0.022095913,0.010735774,-0.0147786485,0.034094922,0.012477465,0.108996,0.04167576,-0.07296997,-0.023695292,-0.045672607,0.10295581,-0.025826214,-0.09178229,-0.02639346,0.08868795,-0.04095506,-0.07438098,0.036325075,-0.0029621844,-0.031104364,0.0015228564,0.04213502,0.044116277,-0.00919903,0.12760538,0.034762733,0.042108484,0.016773425,0.038499113,0.030628124,0.046398394,-0.0010057084,0.015547191,0.06051205,-0.022150131,0.004730983,0.048036996,0.078328274,-0.00038066108,0.0651475,-0.0034634445,-0.016934475,0.0840914,0.06298496,0.06468996,0.05655868,0.04754216,0.03937247,0.042694584,0.132759,-0.019239143,-0.036263943,0.044530883,-0.022373736,-0.035712715,-0.042387005,-0.06239447,0.0028376798,-0.0039374894,0.07219791,0.0024614453,0.009933868,-0.06356595,-0.04373883,-0.033427037,0.034352425,0.07395968,-0.092682704,-0.059340123,0.052482493,0.038445503,-0.00079164025,-0.053532425,0.05089241,-3.2831856e-08,0.097331375,-0.07958651,0.011537223,-0.031107932,0.0043428317,-0.034819983,0.060975127,-0.027400155,0.02314909,-0.10196435,-0.017527571,-0.04079527,0.049628496,0.032794997,0.016062452,0.06642909,-0.004609027,0.00025363732,-0.019907326,0.028233211,-0.10126617,0.032389674,-0.05771034,-0.03419481,-0.04562141,-0.030974662,0.019146213,0.054835204,0.037412047,-0.009967316,0.07196952,-0.015842605,0.06253337,-0.079796724,-0.0531966,0.082278654,-0.124343984,-0.07410474,-0.019941982,-0.029785734,-0.045412153,-0.06380912,-0.0042994865,-0.041392367,-0.07104566,-0.03699336,0.057512745,0.024010563,0.028564908,0.0022304193,0.00014666344,0.00977981,0.038330022,-0.039128758,-0.10685308,-0.040600162,0.046547286,-0.015920697,-0.036822386,-0.08243922,-0.014254606,-0.03227008,0.08818951,0.09220334 +1.13.12.7,"The enzyme, which is found in fireflies (Lampyridae), is responsible for their biolouminescence. The reaction begins with the formation of an acid anhydride between the carboxylic group of D-firefly luciferin and AMP, with the release of diphosphate. An oxygenation follows, with release of the AMP group and formation of a very short-lived peroxide that cyclizes into a dioxetanone structure, which collapses, releasing a CO2 molecule. The spontaneous breakdown of the dioxetanone (rather than the hydrolysis of the adenylate) releases the energy (about 50 kcal/mole) that is necessary to generate the excited state of oxyluciferin. The excited luciferin then emits a photon, returning to its ground state. The enzyme has a secondary acyl-CoA ligase activity when acting on L-firefly luciferin (see EC 6.2.1.52).",384,0.99999994,-0.045582738,-0.051462065,-0.022653192,0.022671947,0.07151036,0.014633282,-0.0031461995,-0.015525703,0.05924981,0.075075015,0.02481587,-0.03209906,-0.10056873,0.022694908,-0.048018206,0.11757013,-0.0713956,-0.06636181,-0.048514254,-0.015421374,0.06799358,-0.009726463,-0.014050324,0.0028242448,-0.009153751,0.011128543,-0.01469568,0.020551916,-0.016688338,-0.06935948,0.06587319,-0.05613802,-0.060958404,0.018247522,0.010804777,0.071563385,-0.022863414,-0.05756702,0.024916561,0.06276036,-0.0123402,-0.035279233,-0.06363504,0.024399748,-0.07569552,-0.035015725,0.035137385,-0.059763882,0.027763644,-0.058924913,0.030398848,-0.021580528,-0.02542016,0.10179133,0.04255224,0.023297407,-0.023925982,0.00036272613,-0.048540153,-0.07396306,0.015260591,0.027778078,-0.025726702,0.031172486,0.008716906,-0.07055102,0.029373279,-0.08319451,0.048688836,-0.1167181,-0.03282403,-0.022078546,0.023156747,-0.034528878,-0.02339213,0.04786425,-0.00071656174,-0.034974087,0.031668164,0.031964615,0.06235832,-0.0065037725,0.04854118,0.12415798,0.07226058,-0.005449613,0.08168112,0.052115157,-0.051239207,0.07600253,-0.081990786,0.0025025953,-0.050461993,0.018399682,-0.07574342,-0.036209762,0.1308603,-0.027281577,0.03205966,0.023318231,-0.042308122,0.043158457,-0.05786533,-0.07637211,-0.05885261,-0.045005098,-0.010648671,0.11747032,0.07696012,0.015459587,0.04535782,0.009011163,0.03621344,0.06315719,-0.0117613785,0.06538169,-0.042529523,-0.0046477607,-0.03422648,0.035634942,0.042495523,0.039322525,0.028249724,0.082149036,-0.03530561,0.017860342,-0.13613838,1.4316112e-33,0.106430456,0.042243917,-0.027741663,0.016586453,-0.029593842,-0.075097255,-0.11798072,0.042006526,-0.04128807,-0.0006438026,-0.025758646,0.018763177,0.10467489,0.009872162,0.0082052015,-0.03615203,-0.04964356,-0.058540236,0.050423328,-0.01989794,-0.040089026,0.032765735,0.020880809,0.041224744,0.0071342075,0.060954377,-0.08790707,0.044051766,-0.022355525,0.023110006,0.05126768,-0.091669455,-0.056919016,0.0089865215,0.06968329,4.7733778e-05,-0.05328698,-0.055040047,-0.023063065,-0.0040907287,0.01215713,0.01931001,-0.022780405,-0.010973366,0.05764812,-0.05868515,-0.0944967,0.09447097,0.07775077,0.06364128,0.00055203744,-0.03977785,0.17455943,0.0035552522,-0.047893517,0.07012089,-0.030309407,-0.118555054,0.02817364,-0.012523656,0.026090313,0.022586426,-0.022625243,-0.018586103,0.018987264,0.008664258,-0.014552677,-0.014527892,-0.0103582125,0.010749637,-0.027911225,0.04985711,0.023019968,-0.03933282,0.02366963,0.023935357,0.0024930362,-0.00802145,-0.033154897,0.023573551,0.055843532,-0.07650079,0.04980283,-0.06388011,-0.03373769,-0.027274912,-0.009219253,-0.019493258,-0.05396983,0.09855223,0.022668434,-0.085780784,0.057138264,-0.080130264,0.03197529,-1.6061887e-33,0.10345324,-0.095912404,-0.073861636,-0.078003444,0.04406721,0.059034202,-0.025572535,0.0016632493,-0.039385557,-0.02269866,0.0036421062,0.061474036,-0.019511282,-0.013425111,-0.010815018,-0.065822855,-0.026998272,0.06391265,0.08062296,-0.0018746413,-0.037779473,0.06395887,-0.010496892,-0.011111015,0.031914346,0.02683326,-0.0019852128,0.0032611685,0.016200982,0.0065683257,-0.0010252584,0.038164552,-0.023955444,-0.014148068,-0.015197562,0.06633771,-0.0719363,-0.054819796,0.032897227,0.062289648,0.040739045,0.013940222,0.019548707,-0.0036688196,0.028008863,0.064839765,-0.0817025,0.014329896,0.010862908,-0.020889224,-0.0032820788,0.028983563,-0.09950925,-0.005840426,0.007901691,0.032852765,0.01895017,0.008241647,0.057804994,-0.0093903355,0.0070677227,-0.09112242,-0.0040239617,0.09056099,-0.05552845,0.052184813,-0.018083813,0.10293832,0.060813297,0.014512816,0.06241755,0.03796808,0.035536148,0.006160221,-0.028837329,-0.03315868,-0.043753102,-0.04378466,0.045609005,-0.030247604,-0.015021049,0.063719206,-0.0021526765,-0.0467592,0.03815401,-0.055717565,-0.017383527,0.058616836,-0.10036386,-0.06530736,0.013706377,0.028985966,0.04394571,0.033692367,0.05792982,-4.8297213e-08,0.02879254,-0.021561211,0.07269214,0.017212382,0.074495085,0.07270096,0.085271165,0.007809478,0.006199339,-0.09392057,0.0357699,0.09030947,0.0827688,0.0099883,0.05655689,0.01563009,0.017652396,0.020431478,-0.04321687,-0.038842347,-0.12789844,-0.019327046,-0.060625006,0.061310478,-0.0298041,-0.04931608,0.017949222,0.046927724,-0.03354882,-0.004245694,0.0055317488,0.04397882,0.035149757,-0.084800005,-0.09506964,0.002426112,-0.054626074,-0.024070619,-0.0257337,-0.046262596,-0.0015457049,0.000761761,-0.021934321,-0.006989553,0.008098383,-0.00024867064,0.057442162,0.0027448388,-0.03171026,0.03599497,0.08271944,-0.029724462,-0.054854706,-0.03394688,-0.12939236,-0.043653578,0.018342469,-0.038354352,-0.009296457,-0.11147075,0.03420466,0.0148571795,0.13024633,-0.049802788 +1.13.12.8,The enzyme from the luminous squid Watasenia may be assayed by measurement of light emission.,384,1.0,-0.021709494,-0.009632105,0.035903797,0.023658743,0.0029905445,-0.032011583,0.026994357,-0.0108986255,0.0068774563,0.056316447,0.0106692435,-0.11929527,-0.036312692,0.13648595,-0.022251016,0.00704813,-0.010162988,-0.052311465,0.00046769885,-0.059571467,0.10802904,0.011452556,-0.0018702615,-0.037200645,-0.03208453,-0.011660037,0.022320114,-0.06620347,-0.022376267,0.0075169415,0.037395183,-0.057567853,-0.035766713,-0.036492933,0.011877666,0.0025512257,-0.038992994,-0.079513445,0.046682272,0.03081839,0.05026381,-0.028660135,-0.008730675,-0.022473931,-0.065449394,-0.033643063,0.0012783908,-0.0036317033,-0.044571675,-0.06664803,-0.036367517,-0.1155818,-0.045814432,0.011797995,0.058498293,-0.0054383134,0.0029869112,-0.07825293,0.0084580025,-0.08282408,0.0038349489,-0.003882659,0.036133513,-0.004842536,0.015251276,0.041264605,-0.02707829,-0.0034923293,0.013429233,-0.06299209,-0.09956756,-0.0018057863,0.051026937,0.01300317,-0.05970137,-0.03219752,0.040587705,0.0016351076,0.064135015,-0.017732726,0.028938808,-0.052652895,-0.05899188,0.118761964,0.16825517,0.095978044,0.046115085,0.01738007,-0.08204357,0.009468902,0.07127825,-0.025762478,-0.101803444,-0.029955983,-0.03433116,0.031445306,-0.0021054316,0.011960574,0.010121883,-0.034212135,0.0039074332,-0.044286758,-0.051366143,-0.060472183,-0.054924052,-0.027202334,0.07967817,0.0698409,0.07906404,0.03551851,-0.029025009,-0.012122022,0.08230407,0.019622989,0.008946763,0.07232731,0.014463314,0.022241907,-0.055436816,-0.0021514932,0.061988078,-0.023699967,0.122654326,0.012986083,0.0387355,0.020768961,-0.045777805,-1.694433e-33,0.1268479,-0.03549211,-0.025320671,0.054353073,0.052315727,0.0068370136,0.014822668,0.061645497,-0.11328229,-0.04566901,-0.019630836,-0.019316569,-0.017148728,0.025395805,0.032398947,0.041943405,-0.0033604205,0.0057840683,-0.027004179,-0.011475808,0.017987175,-0.04442953,0.011303168,0.027605109,0.0021285738,0.008643821,-0.0904342,0.046273526,0.012904859,0.017849602,0.030541116,-0.07671224,-0.10733145,0.04108788,0.009502308,0.00011584276,0.024273874,-0.010436475,-0.0915654,-0.061019942,0.039911915,0.020330776,0.06577731,-0.015133796,0.021510739,0.017466445,-0.043726236,0.064838134,0.14427106,0.015051852,0.07775443,-0.045377392,0.048801407,-0.12744923,-0.02527581,0.11230371,0.017565181,-0.018493678,0.019462341,-0.025378244,-0.019442184,0.03684924,-0.010443671,0.026688907,-0.027535765,0.06491319,-0.015126751,0.03553247,-0.048906546,0.028816726,-0.032416373,-0.035311926,0.006717722,-0.04109227,0.0021510948,-0.00026791342,0.023217818,-0.024493346,-0.03024322,-0.017903112,0.08529367,-0.058970477,0.05963425,-0.04437736,-0.060654927,0.011238876,-0.0096020745,0.009818858,-0.025047623,0.05993608,0.10267251,-0.015703075,-0.03820843,-0.06732529,-0.11475477,-2.536828e-34,0.030378265,-0.029715167,0.029707517,-0.015530183,0.02123095,0.051643386,-0.008245578,0.04829795,0.07604707,-0.008833222,0.08176879,0.04541118,-0.04972598,-0.09288915,0.04909197,0.045108136,-0.036890235,0.011699477,0.03398035,-0.054042455,-0.06306342,-0.01432157,0.04268859,-0.054114718,0.031312153,0.072885275,0.10619226,0.092599966,-0.009767049,-0.047625307,-0.075014494,-0.020520521,-0.034708634,0.036816914,-0.013735541,-0.007835261,0.05185317,-0.076041065,0.030706067,-0.02130901,0.023064582,0.0041817767,-0.0038438088,0.04619815,0.011032308,0.061347097,-0.08803926,0.010291314,-0.01223368,-0.008458275,0.062188923,-0.0018033957,-0.027395718,0.016427204,-0.0012692357,0.061891414,0.031641074,0.042381074,0.05534797,-0.0029959083,0.0132374475,-0.079290494,0.011536563,0.06549715,-0.033114,0.022700263,-0.0054107876,0.091570266,0.002397001,-0.0063826265,0.11952782,-0.01584491,-0.07653134,-0.0059702084,-0.036006954,0.010304745,-0.06762135,-0.07398932,-0.00032762653,0.012947348,0.02842988,0.029855438,0.033584043,-0.1353765,0.04237746,-0.075551264,0.00039203852,0.022729127,-0.018146014,-0.04487772,-0.059243325,0.022376588,-0.034071855,-0.066166565,0.12555625,-2.0637707e-08,-0.0029790131,-0.045555983,0.077146985,0.033204094,-0.013691712,-0.020785976,0.032508124,0.011311797,0.055943985,-0.0361839,0.006155717,-0.023515396,-0.004292316,0.07190272,0.03348501,-0.02957517,-0.043225937,-0.069260515,-0.045776445,-0.034263976,-0.05361019,0.0006388661,0.014780596,0.010892093,-0.028124662,0.034184378,0.01657495,0.053524904,0.023914784,-0.040804558,-0.04180655,0.029500974,0.042075574,-0.0033509166,-0.13902539,0.011981281,-0.13888949,-0.039914113,-0.056611806,0.12338961,-0.007870584,-0.044726238,-0.0026679905,0.018159073,0.0043955087,-0.013932008,0.009146517,-0.006148249,-0.023702204,0.034245588,0.094514914,-0.007500607,-0.046797123,-0.06845062,-0.17728908,-0.056768864,0.023825018,0.036750697,-0.08069931,-0.030357875,0.06703041,-0.010702568,0.110584654,-0.017014045 +1.13.12.9,"The reaction shown above is about 80% of the reaction catalysed; the remaining 20% is:     L-phenylalanine + O2 + H2O = 3-phenylpyruvic acid + ammonia + H2O2 a reaction similar to that of EC 1.4.3.2, L-amino-acid oxidase.",384,1.0,-0.01161943,-0.0016074749,-0.07573265,0.013517565,0.113341816,0.010215698,0.02246837,0.0314903,0.008164204,0.013767048,0.080953754,-0.06557404,-0.029613929,0.004890704,-0.037211765,0.08671001,-0.078037865,-0.03668081,-0.14081809,-0.04684927,0.038110252,0.019601077,0.037489593,0.004541169,0.03811038,0.00064904103,0.052864138,-0.041181155,0.0125050545,-0.024830298,0.040197305,-0.07158464,0.059372757,-0.11219963,-0.007940289,-0.0075113517,-0.036279056,-0.13055533,0.02677817,0.037680097,0.002694058,-0.0074006985,-0.027591525,-0.042006623,-0.020376243,0.04461231,0.0111557515,-0.024278464,0.027960302,-0.01041429,-0.015023914,-0.052617732,-0.036071673,-0.060366005,-0.0016572747,-0.011180301,-0.08300481,0.010299142,0.012686262,-0.027192593,0.01822344,0.058988556,0.010272416,-0.008896013,0.0012560727,-0.088759124,-0.056058373,-0.13958043,0.012734149,-0.024709549,0.0139589105,-0.08784303,0.058634497,-0.07873323,0.0017861921,-0.03517096,0.019094488,-0.012229246,0.04950112,0.0054577375,0.04578128,-0.040329367,-0.027837766,-0.018178603,0.0023412164,0.00023368506,-0.03637875,0.0044076256,0.097823344,-0.028152118,-0.029921917,-0.044568177,0.0049557216,0.018812465,-0.0074023046,0.036815953,0.040576622,0.005290968,-0.015490417,0.025504503,-0.08379002,0.10821726,-0.039302498,-0.14197277,-0.060073525,0.02681168,0.03430625,0.14020759,-0.0036233186,0.038468916,0.03524606,-0.06996319,0.019176826,0.04730141,0.037256442,0.06884913,0.057223808,-0.08426791,-0.06399398,-0.018928804,0.033439,-0.020967273,0.06811326,0.08997455,-0.08578253,0.017464515,-0.061314017,5.269927e-33,0.030005587,0.038227186,-0.021698771,-0.03450551,0.01909104,-0.021434784,-0.06178666,0.047039732,0.100460015,-0.063003935,-0.14492667,-0.06759091,0.009114912,0.020618739,-0.10019166,-0.053261828,-0.011315279,0.03809224,0.025234388,0.031494446,-0.01880498,0.027261032,-0.027306799,0.078166716,0.022000993,-0.010779701,0.0117539335,-0.05020497,0.010867384,-0.015663108,0.056117594,-0.06363626,-0.07736324,-0.09245973,-0.13173054,0.008772004,-0.10925664,-0.02049974,0.013998676,0.093740486,-0.04868573,0.02605497,-0.018579422,-0.03795793,-0.022733826,0.020045226,0.025678946,0.0881435,0.056321315,0.05483001,0.00052366045,0.012040878,0.02220396,0.03894581,-0.04515011,-0.022212448,-0.010684013,0.007010479,0.11008554,0.081234984,0.030026767,0.06757441,0.026523655,0.010441959,-0.023103395,0.022961916,-0.017262828,-0.02021604,0.013936764,-0.0031167255,-0.050137315,-0.01000037,0.13133433,-0.013953696,-0.008376012,-0.07547642,0.00064572075,-0.010047928,0.025926925,0.017740041,0.023839863,0.018604828,0.010561846,-0.02827094,0.0074302824,0.022563249,-0.033646423,-0.033456326,-0.05279592,0.09279231,0.009683813,-0.11045471,-0.027524082,-0.01936963,-0.0065134964,-5.420598e-33,0.024107,-0.065181606,-0.019907024,-0.07309329,0.011052049,-0.011109583,-0.023057053,0.037119634,-0.017181452,0.018675212,0.06592257,-0.0036493097,0.06777122,0.028327975,-0.0077596884,0.020210322,0.035664394,0.10059682,0.054331217,0.013342041,0.053284347,-0.027304713,0.031100767,0.04346516,0.09946108,0.07027101,-0.02753185,-0.037427507,0.06582385,0.053457186,-0.036112256,-0.06611126,-0.031481948,-0.027393684,-0.012634854,0.059667822,0.023244824,-0.015325909,0.051976983,-0.014731601,0.019723216,-0.076932155,-0.025066253,0.0644897,0.046288375,0.029116835,-0.018369181,-0.011502927,-0.0143058365,-0.08541618,0.090304874,0.057958372,-0.04046287,-0.019658761,-0.03375882,0.08439315,-0.010394573,0.0041865204,-0.012170106,-0.0097931605,-0.0007355631,-0.08253677,0.03407392,-0.035736363,0.037370037,0.058225147,-0.025390992,0.08555871,0.058323048,0.009218964,0.08665512,-0.0071998127,0.06569499,0.063812815,0.039989788,-0.03711494,0.021287302,-0.03864839,0.059460796,-0.05158176,-0.023430211,-0.11049156,0.05734082,-0.064497314,-0.009441848,-0.07720972,0.022232877,0.036425233,-0.03301529,0.041279435,-0.04509837,-0.0008218236,-0.012557082,0.036279026,0.109742604,-4.2517655e-08,0.023267573,-0.09474656,0.05334543,0.001105908,0.052200835,0.10452935,0.015621028,0.02322273,-0.05383589,-0.06607953,0.014259419,0.07822627,-0.06849347,-0.011616404,-0.028044978,0.035474006,-0.07181893,0.0729089,-0.0013689054,-0.069124736,-0.010964235,0.032627396,-0.053195033,-0.0073260954,-0.021056503,0.0033798723,0.018530764,0.069481984,-0.07412219,-0.12331052,0.034228668,-0.059423376,-0.035983335,-0.015353705,0.015472012,0.011774473,-0.03572499,-0.019155154,-0.035891604,-0.013525174,-0.119373985,-0.010409587,0.005865016,0.048920862,0.042671807,0.03332275,-0.023836358,-0.016391896,0.0017020458,-0.07927692,0.09309241,-0.040801547,-0.0012854451,0.031217556,-0.07080668,0.008181491,-0.031443603,-0.051188696,0.011068558,-0.007048019,0.011029097,0.082944974,0.13330907,0.02849201 +1.13.12.11,A flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.13.12.12,"A thiol-dependent enzyme. Unlike EC 1.14.99.36, beta-carotene-15,15'-monooxygenase, it is not active towards beta-carotene. Presumably, 2-methyl-6-oxohepta-2,4-dienal is also formed in this reaction.",384,1.0,-0.024787534,-0.003132666,-0.07741107,-0.0036332752,0.060164724,0.026239228,-0.11415411,0.050899666,0.029452441,-0.012523911,0.03402116,-0.08396443,-0.05483579,0.031963795,0.005955482,0.06822059,-0.04263837,-0.06714224,0.020585634,-0.045561355,-0.03249331,-0.008802942,-0.0024422144,0.009638013,0.052602906,-0.010314969,0.052441802,-0.032369483,-0.101478435,-0.053403713,-0.03336851,-0.042349603,0.028065817,-0.035338864,-0.0474462,0.028770026,-0.09745528,-0.062364906,-0.021053826,0.028758772,-0.00060109724,-0.053859524,-0.09629321,-0.030505855,-0.009746464,-0.09382801,-0.049805127,0.07757397,-0.00091263384,0.02539163,-0.04037629,-0.13589203,-0.0063427207,0.031146007,0.011624659,0.0056310142,-0.08068974,0.013984516,0.020887557,0.038984124,0.062281493,0.03909652,-0.0054892735,0.016294915,0.027389344,-0.033830233,-0.023693822,-0.022306228,-0.061535392,-0.07079151,-0.009414341,-0.08984834,-0.0063858526,-0.026567621,-0.008224818,-0.021478433,-0.014578839,-0.010936123,0.09113394,-0.037873883,0.017826328,0.030462062,-0.0035588546,0.037002847,0.0322352,0.002968199,-0.018922096,0.006251911,-0.030101852,0.03317297,0.042266898,-0.0058922805,-0.036296945,0.009244927,0.010969393,0.0060225665,0.08665897,-0.057160903,0.024695838,-0.013191912,0.025393914,0.087228686,-0.08337645,-0.018158784,-0.025092138,0.039473876,0.025619391,0.04063053,-0.0039236797,-0.02748663,0.064456455,-0.02461745,0.06710361,-0.008557055,-0.0292596,0.08841732,-0.051887494,-0.08375243,-0.06575978,-0.014988858,0.02423653,-0.022916535,0.035565175,0.072500624,-0.0026717663,0.004049723,-0.07630266,-1.636331e-33,0.12849563,0.017514637,0.018247308,-0.031212533,0.06252031,-0.038723174,-0.016443977,0.07162845,-0.056806035,-0.00992286,-0.050744552,-0.0520458,0.010083744,0.01347882,0.052347425,-0.045061108,0.002999813,0.018112501,0.06472357,-0.0064196535,-0.08264376,0.013227922,-0.08008772,0.02084455,0.019014811,0.050084546,-0.018070804,0.05371811,0.024002185,0.028644769,-0.015458891,-0.07460049,-0.052300565,-0.004930506,0.02305191,0.004627386,-0.07993479,-0.009892992,-0.092714556,0.025983853,0.042843264,0.033920467,0.024757473,-0.07521019,0.02942568,-0.054494124,-0.015405342,0.035027735,0.05194974,0.058456287,0.0059714746,0.02298906,0.081285045,-0.06471637,0.014729288,0.06926944,-0.024535406,0.07860633,0.026311062,0.045202345,0.015670937,0.03299381,-0.059068944,0.034117177,-0.05284645,0.099438444,-0.12040046,-0.103238694,-0.045351937,0.06350938,0.015614764,0.1025023,0.06325508,-0.020033823,0.02592157,-0.0015689458,-0.044313237,0.012105403,0.014887315,-0.046467386,0.009572057,0.0012574667,0.0029288868,-0.07341736,-0.017309364,0.009500195,0.0191771,-0.042023532,-0.014032748,0.0698862,0.024568802,-0.029087797,-0.08493414,-0.012818267,0.10652014,-4.2146225e-34,0.05745073,-0.0700305,0.046625443,-0.10346059,0.034790486,0.08834576,-0.025375694,-0.07944212,-0.0012189766,0.019075448,0.089602016,0.05898936,0.035472248,-0.053052157,0.07398993,0.006310864,-0.05503322,0.028254457,-0.044292666,-0.000815533,-0.00293308,0.03294884,-0.04188417,0.024158228,0.020886688,0.03898004,-0.038393345,0.051443342,0.093071945,0.007524193,0.005707717,0.013591192,-0.024731835,-0.0073626623,-0.0012555158,0.06113187,-0.06233877,0.009445574,0.039488297,0.10744452,-0.04623571,-0.032816313,0.027366968,0.08620756,0.04414313,0.09097986,-0.029373517,-0.028532213,0.05615069,-0.072622985,0.047082935,-0.008759809,-0.034575038,0.087711215,0.03380669,0.05534253,-0.00742079,0.024662193,0.027794825,-0.12848131,0.012760913,-0.075415306,0.03814683,-0.058772106,0.0055414164,-0.03632069,-0.07570692,0.05571877,0.085106134,0.038322862,0.08623168,-0.03716793,0.0068563377,-0.031941652,-0.03531506,-0.07475576,-0.06351197,-0.046834033,0.0076759164,-0.027367778,-0.00034291577,0.08050337,0.040474888,-0.068874136,-0.061872546,-0.035869427,0.015090243,0.09262972,-0.028186414,0.09013905,-0.009670299,0.055038,-0.04997862,0.059747983,0.0650807,-3.880254e-08,0.060840633,-0.06704813,0.0058109798,-0.014774213,0.011708615,-0.029281717,0.07934013,-0.011572822,0.05381442,0.015487394,-0.058109254,0.064587675,0.059577864,-0.030286439,0.049430232,-0.06917781,0.005262812,-0.010857015,-0.02929845,-0.047877703,-0.02797272,0.03270459,-0.05165518,-0.016201686,-0.022697983,-0.05726082,-0.014476553,0.007977912,-0.04375111,0.001679972,0.043007955,0.11066394,-0.03250363,-0.06032003,-0.109024376,0.03283669,0.04711904,0.013499507,-0.053650275,0.011626055,-0.009653146,-0.09769502,-0.12925367,0.04254858,-0.019161088,0.0106827365,0.100789554,-0.010349907,-0.008326402,-0.031612568,-0.051902752,-0.03549867,-0.011305078,-0.009970709,-0.018582636,0.048352562,-0.003055105,-0.00389385,-0.038839377,-0.07689373,0.08914285,0.025280207,0.22280078,-0.0073730727 +1.13.12.13,"The luciferase from the deep sea shrimp Oplophorus gracilirostris is a complex composed of more than one protein. The enzyme's specificity is quite broad, with both coelenterazine and bisdeoxycoelenterazine being good substrates.",384,0.99999994,-0.058750287,-0.0340772,-0.09775565,-0.04181465,0.05568702,-0.060702305,-0.05238456,0.011144611,0.0841983,-0.035777148,0.0053979415,-0.09746853,-0.028394897,0.093785204,-0.039789394,-0.019233907,-0.04514211,0.048508998,-0.035116613,0.04594449,0.037747927,0.05144589,-0.022113368,-0.041901905,-0.06989483,0.083137184,-0.064495124,0.025794655,-0.008572124,-0.092333846,0.009958648,-0.0129979905,0.0730601,0.026294991,0.01601311,0.0662003,-0.033629987,-0.030962689,0.06474014,0.0891175,0.00061493384,0.013493625,-0.009802376,-0.011520408,-0.075217284,-0.066117704,-0.01533201,-0.06915772,0.05997379,-0.038214162,-0.03177899,-0.08870475,-0.024050776,0.06727793,-0.013306929,-0.024810575,-0.09887554,-0.02327317,-0.06331866,-0.02025804,0.082546726,0.095491156,-0.06010844,-0.0070100017,0.04914051,0.022732731,0.00069916004,-0.005370419,-0.028673386,-0.034744862,-0.015811088,-0.012721606,-0.03179996,0.07775008,-0.033900555,0.020117028,0.027337767,-0.020119367,0.032698758,-0.012549553,0.06026507,-0.018185182,0.0051378445,0.077202484,0.108974524,0.042954512,-0.0025164539,0.021201145,0.019607598,0.09435518,0.028348716,-0.04639836,-0.04159426,-0.08499692,-0.035616014,0.03315078,-0.06348637,0.0013731448,-0.0255702,0.060211264,-0.024911523,-0.06933677,0.05406924,-0.056916356,-0.041558295,0.0053137043,0.02592909,0.08266962,0.034635153,0.0034066788,-0.045608453,0.0031370763,0.059652574,-0.0069907294,-0.018255683,0.11206736,-0.05908186,-0.0048608286,-0.029901436,0.04004908,0.022175377,0.02671164,0.086027585,0.08742073,-0.016834062,0.06731276,-0.12041759,3.7692226e-33,0.028204393,0.08481725,0.0023022636,0.014968214,-0.0013347486,-0.027208421,-0.062800586,0.053390075,-0.041676074,-0.023071496,-0.09361616,0.0571471,0.013062178,0.05105014,0.011306716,0.044067662,-0.013921766,-0.025573928,0.052530754,-0.053742766,0.07226941,0.028606046,0.008447862,-0.09174312,0.028169854,-0.022370944,-0.054393776,-0.01467995,0.025824035,0.023813883,-0.01827471,-0.07763633,-0.08274291,0.06492544,0.067178465,0.039009955,0.0021058228,-0.09432154,-0.007239975,-0.08519893,0.06093146,0.003175157,-0.0067568826,0.03223125,0.08797209,-0.07760415,-0.09206864,0.09514899,0.039163694,0.08731962,0.060263276,-0.036942966,0.0066425446,0.005748295,-0.114885285,0.088504426,-0.028303148,0.011905584,0.03253778,0.030488744,-0.051064737,0.038872052,-0.026877668,-0.03675263,0.028217258,0.06498258,-0.016555343,0.009727233,0.038023144,0.06885974,-0.08144429,-0.040008403,0.052479092,0.00074911467,0.016098754,-0.038481604,0.021142358,-0.09046445,-0.005545082,0.05269466,-0.0036243622,0.00093420496,0.05963202,0.012627222,-0.12525865,-0.004081536,0.07671578,-0.01539982,0.008420488,0.04296877,0.033023793,-0.06549879,-0.05988286,-0.048621867,-0.03948806,-2.9928071e-33,0.050170977,-0.11310895,-0.00033297893,-0.0655034,-0.022515759,-0.0044470793,0.03611531,-0.022584356,-0.03170932,-0.004098891,0.037008405,-0.035291832,0.026521655,-0.107966445,-0.008308522,-0.029048558,0.002048205,0.070882,0.09033646,-0.043536127,-0.061917413,0.057852745,0.07198888,0.06497175,-0.036004324,-0.00034609204,0.07999406,0.09699809,-0.035063025,0.046935476,0.022631133,0.055781744,-0.014640446,-0.038422145,-0.05138259,0.09030964,-0.04073711,-0.025387205,0.027429054,-0.05198708,0.016860161,0.044510957,0.011027701,0.031522702,0.020908933,0.12968054,-0.0003670834,0.026834851,-0.017291067,-0.07065643,-0.0048808316,-0.01946614,-0.030470228,0.0012115483,0.012339048,-0.029852463,0.017737303,0.007249983,-0.00022667181,-0.0038069927,0.004499474,-0.0043772296,0.0060592727,0.06229114,0.09855736,0.053526442,0.043299578,0.049026776,0.037276104,0.071197756,0.056619182,-0.034135945,0.004767064,0.033165295,0.0057798866,-0.04193013,-0.032757614,-0.042152185,0.03876214,-0.014560872,0.030166386,0.0324568,-0.030452108,-0.082289346,-0.011641208,0.029849807,-0.012761625,0.15884897,-0.023264877,0.034258742,0.021210136,0.0131115215,-0.01845105,-0.026826825,0.10667175,-3.4155324e-08,0.10149332,-0.019310946,0.03856922,0.026564786,-0.03513866,-0.016849361,-0.01092396,-0.015874915,-0.026077012,-0.009117367,-0.0020970474,0.026669823,-0.03698156,-0.00681733,-0.0010876952,0.029465169,-0.04457584,0.059523676,-0.055985857,-0.042092975,0.0029051572,0.10658355,-0.07860492,-0.017542955,-0.012358504,-0.02614344,-0.04679312,0.028765256,0.01823397,0.025174957,0.03981032,0.026545357,-0.032492638,-0.033852987,-0.06582175,0.009268651,-0.052441172,-0.065070465,-0.0551503,-0.044431783,0.048794717,-0.006577,-0.0239948,-0.021458212,-0.04505542,0.042690534,0.009799539,0.00021637103,0.02368994,0.02652533,0.07346588,0.026077358,-0.028280118,-0.020458741,-0.18444483,-0.03867593,-0.07863479,-0.05910918,-0.062283825,-0.07143225,0.01104531,-0.07051413,0.13201016,0.029762255 +1.13.99.1,An iron protein.,384,1.0,-0.030547986,-0.03268735,-0.05595656,0.15550317,0.0442354,-0.007506916,0.1622413,0.058103777,0.016559854,-0.058792975,0.0030690578,-0.008893409,-0.075591646,0.017419748,-0.03966154,-0.052111983,0.04198234,-0.025664162,-0.058964368,0.0068538054,0.0027510147,0.04255883,0.006320065,-0.002107357,-0.08329024,0.03714809,0.048363067,-0.026688123,-0.05226514,-0.030014912,-0.020868955,-0.051098548,0.01299584,-0.013005335,0.010010474,0.03439715,0.019343158,-0.08804186,-0.03796503,-0.02848354,0.025082355,-0.04318314,0.011232076,-0.04563005,-0.03692763,0.01863868,0.060054123,0.045620862,0.08031214,0.10587497,-0.06848729,-0.08225148,-0.04627238,0.015060828,0.0038270317,-0.02178657,-0.012633058,-0.05860608,-0.07301761,0.024823286,0.009839735,-0.034348264,-0.036547344,0.0227835,0.1067995,-0.063182995,0.032347493,-0.016381796,0.017907739,-0.0378191,0.044491664,0.037264176,-0.07401127,0.055130348,0.01575915,0.011436892,0.024796715,-0.05587558,0.13305157,0.04799229,-0.046305284,0.029927505,0.012773555,0.08654123,0.05077902,0.040816944,0.035724293,-0.022354916,-0.09736554,0.03525654,-0.02456924,0.02693569,0.0061639952,0.0027245763,-0.0010393744,0.03241702,-0.02799546,-0.011196223,-0.060391255,0.073171824,-0.052279893,0.056657,0.026916659,-0.043743324,-0.01301581,-0.028008236,-0.075971425,0.102866225,0.056486934,0.029414296,0.011236396,-0.003523678,0.031656995,-0.011495763,0.021672964,0.041508224,0.082971364,-0.013394809,-0.052017406,0.05855747,0.044709805,0.042282853,0.00992665,0.061418083,-0.05460479,-0.033508003,-0.055620875,-6.0478332e-33,0.009801702,0.03302355,0.07308017,0.0717402,-0.045413457,0.035399396,-0.08529944,-0.03877216,0.019198408,0.0415423,-0.07346607,-0.035902135,0.053019505,0.019096645,-0.0100326445,-0.10571655,0.0004975177,0.004095414,0.07439895,-0.0051826136,-0.016483264,0.12595978,0.10053588,-0.02218163,-0.009802621,0.003900434,-0.06510544,-0.05278599,-0.066217005,0.020871667,-0.010348511,-0.042238563,-0.061026324,-0.05690128,0.052044537,-0.074288905,0.024347046,-0.09515657,-0.07290331,0.019256324,0.08184817,0.0010281787,-0.04921878,-0.008955797,0.041778803,-0.051745225,-0.02345346,0.062103525,-0.0760717,-0.020936474,0.042986065,0.017649999,0.09250152,-0.034169383,-0.09938647,-0.01682665,-0.005256022,0.026783396,0.0135540115,0.08293358,0.03538349,0.04738584,-0.02766189,0.110920444,-0.0063020573,-0.037647624,-0.061067116,0.0071319146,0.032809302,0.069814816,-0.02330907,0.024190528,0.11841261,-0.056769732,-0.044209834,-0.059741467,-0.10412704,-0.018279396,0.03801016,0.042277716,-0.021437796,-0.037039172,-0.018398965,0.010685505,-0.09204458,0.065621614,-0.015064733,-0.0075299703,0.08099413,-0.079396814,0.0037960778,-0.030279603,-0.026987076,-0.060794983,-0.036137894,3.25156e-33,-0.00015605334,-0.07774647,-0.017012445,0.08494499,0.035413973,-0.017252456,0.010733522,0.00010921009,-0.0657,0.053086944,0.13044572,-0.09169637,0.048356853,-0.0667507,0.07963411,0.14878677,-0.076970205,0.04065113,0.09508405,0.026172925,-0.09290007,0.00073548703,0.0716238,0.046538822,-0.01800282,0.060221285,-0.03058381,-0.05653826,0.006511485,0.075865515,-0.028235255,-0.031092253,-0.0037305208,-0.13466857,-0.06996982,-0.0032241652,0.057824895,-0.04966594,0.0364994,-0.018577367,0.046073556,0.0005558244,0.05080373,0.13955006,0.026521984,0.0026292552,-0.039472908,0.009942361,-0.012719961,0.04213727,0.050094794,-0.066648014,-0.02863319,-0.0040481933,-0.02979368,-0.023425626,-0.025050394,0.04482483,-0.027972117,0.115378596,-0.021861667,-0.019194547,0.07146641,0.065466635,0.038437363,0.032645747,-0.03750081,0.0140900165,-0.031438697,0.0074316496,0.0998737,0.047383063,0.06459466,-0.029312909,0.054895923,0.002885127,0.016903544,0.038604148,-0.048839252,0.049689915,-0.11545964,-0.045598958,-0.017762046,-0.0047896784,0.050341357,-0.06856544,-0.0003149344,0.009648166,-0.03239399,-0.022178855,-0.06619679,-0.06597968,-0.05316923,0.01973258,0.0031741718,-1.2778442e-08,0.010725331,-0.04179835,-0.029455876,-0.067830175,-0.005872341,0.020825097,0.001838066,-0.085639216,-0.013044954,0.022963153,-0.012202513,0.10366144,-0.0036974312,0.024328334,0.017121114,0.0022789757,-0.020842846,0.052050963,-0.022122433,-0.011968845,0.008456651,0.022542236,0.067895524,0.0015558144,-0.03595551,-0.06570697,-0.04500874,0.015109252,0.024354307,-0.006388884,-0.03331594,0.055960137,-0.026549146,0.010442001,-0.06346821,-0.004715345,-0.008321135,0.0033110196,-0.07312384,0.009063667,-0.06763877,0.017750904,-0.06699612,-0.026215198,0.008498962,-0.027425637,-0.048921864,0.039026536,-0.03191648,0.021714957,0.04802261,0.018943755,0.065556645,0.023598526,-0.0036381017,0.038427502,0.007216478,-0.08516541,0.00024349778,0.009282982,-0.024277324,-0.059714332,0.042911,-0.0397725 +1.13.99.3,"A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.",384,1.0,0.006292263,-0.061049584,-0.007028664,-0.034126297,0.031671572,0.005940114,0.021234851,0.024096023,0.06577297,0.004579346,0.054477748,0.0044305394,-0.08572514,0.085831836,-0.008575222,0.07493674,-0.03977856,-0.006193358,-0.022008063,-0.029453272,-0.016571067,0.07277031,0.016304059,0.024864197,-0.028043522,-0.03229273,0.062969804,-0.044835407,-0.045504697,-0.060451224,-0.035236012,0.01858109,0.024268802,-0.0006076088,-0.017776534,0.05161987,-0.05233811,-0.04381472,-0.005209928,-0.016630646,0.0341461,-0.06903559,-0.07786715,-0.005196832,-0.024021365,0.028423468,0.05276888,0.04374204,0.027217975,0.02959281,9.787074e-05,-0.018267995,-0.08910463,0.05319268,0.011187984,0.019871773,-0.05581429,0.082022674,0.013054671,-0.0030654322,-0.022279676,0.05646821,0.022128025,-0.021648357,0.022352763,-0.1047144,0.07984965,-0.01994311,-0.014798654,0.030080948,-0.051250968,-0.024241984,-0.071244776,-0.008252539,-0.00042677912,0.034531582,-0.0023496437,-0.08874123,0.03744939,-0.079385184,0.014119078,0.015344111,0.07035983,0.17437717,0.008042088,0.02824437,-0.0918299,-0.0019207142,-0.062017426,-0.062594764,0.022480829,-0.008174077,-0.01734096,-0.02316872,0.03197939,0.045882974,0.017579092,-0.0467641,-0.04194405,0.037242156,0.026669765,-0.0034902508,-0.05561116,-0.05034809,-0.048803024,-0.0030890498,-0.03352274,-0.029409073,0.04547034,-0.042288933,-0.011301063,-0.0010857568,0.07573538,-0.011753321,-0.08422113,0.030083753,-0.0075912517,-0.0446205,-0.026730634,-0.024956448,-0.011005979,0.059939474,0.011173482,0.05623004,-0.06846303,0.013173869,-0.018184256,-1.7651898e-34,0.090042256,-0.0005375479,0.07396655,0.041760936,-0.075887576,0.008566026,-0.05704779,-0.029373584,0.020265307,-0.002593933,-0.0063532954,-0.06506928,0.0803449,0.0031676209,0.057994053,-0.009373954,-0.1175972,0.03636101,0.032602612,0.012350461,-0.08158908,0.017316554,-0.053450033,-0.041980013,-0.010651837,-0.004986978,0.02476618,-0.04186346,0.022449061,0.026348213,-0.024651013,0.008294469,-0.10981037,-0.03387996,-0.030631196,-0.002146587,-0.03450994,-0.0074128006,-0.095657825,0.019471202,0.01012802,0.0824454,-0.015316093,-0.041756786,0.0664452,0.04534704,-0.021440418,0.11604705,-0.048085213,0.0923952,-0.012918488,-0.0642204,0.11059665,-0.048961565,-0.014279986,-0.03528949,-0.0131182615,-0.011812021,0.058967847,0.053482454,-0.036100015,0.037284747,-0.06202182,0.036429472,-0.036559574,-0.0025702638,-0.118435495,-0.051436868,-0.041368067,0.03761078,0.01825908,0.07026446,0.097622596,0.009198338,-0.080993615,-0.01862884,-0.09407325,0.016618261,0.032853585,0.022607474,0.07475304,-0.05610955,0.04209266,-0.057433672,-0.024264663,-0.038976416,0.022265073,-0.06294841,-0.03380607,0.015746346,0.060746048,-0.04662372,-0.005420047,-0.013130923,0.05837347,-1.1191211e-33,0.043823414,-0.10469908,-0.054224133,-0.037234746,0.005470543,-0.019072695,0.055186443,-0.039007634,-0.035267323,0.013388628,0.086315215,0.016780894,-0.0034786847,-0.0005558648,0.08931066,-0.016673028,-0.072104104,0.05686001,0.042969547,-0.0018520032,0.019779732,-0.039517738,0.013923448,0.11825527,0.05989435,0.049479242,-0.068090945,-0.0020518673,0.012035216,0.048923906,-0.01637693,-0.062355675,-0.027649453,0.03331088,0.044861097,0.0608799,-0.02829101,0.049280737,0.038517833,0.002621141,-0.03998675,0.051987886,0.10220018,0.024222147,0.020316085,0.12610368,-0.070088394,0.06263656,0.04101609,-0.09353147,-0.07773896,0.008823223,-0.037734192,0.0012755166,0.050358586,0.077525795,0.028114054,0.02083118,0.0108523825,-0.018340046,-0.09852219,0.009120419,0.04193027,-0.016943,-0.07379456,0.100046754,0.029040454,0.058177125,0.054043923,-0.071305424,0.04367384,0.022837538,0.108241476,-0.049585115,-0.03733853,-0.10929028,0.019251466,0.015603993,0.0033196607,0.037410855,0.040139258,-0.0005385204,0.005469293,0.0010344009,-0.013642566,-0.09519897,-0.00082097045,0.09273942,-0.009223991,-0.022796169,-0.008185334,0.015276766,-0.042430095,0.05485156,0.10970131,-3.9617795e-08,0.020557392,-0.10591668,0.06302093,-0.066045,-0.04509224,0.049552113,0.044469684,0.10273525,0.07090661,-0.0743418,0.025668845,0.060376845,-0.014305386,0.014328085,0.10988279,-0.03589748,0.00016636887,0.023348203,-0.04215467,-0.051682398,-0.07291351,0.0027420942,0.019510085,0.008780564,-0.05066892,-0.0544776,0.0039499165,-0.09314511,0.073914826,-0.061123915,0.012933164,0.07266929,-0.034116324,-0.023261443,-0.03431974,0.016615162,-0.025897782,0.056373775,-0.017004937,0.056324,-0.06144349,-0.0689535,-0.077094294,-0.029878806,0.1195501,-0.057344057,0.04602237,-0.0014900547,-0.034796823,-0.0711461,-0.038727444,0.012752327,0.021999542,0.04049013,-0.043766685,-0.02997865,-0.06311564,-0.04515331,-0.0104268445,-0.0871906,0.06602238,0.07687674,0.10955326,0.067858666 +1.14.11.1,Requires Fe2+ and ascorbate.,384,1.0,0.004124434,-0.051354267,-0.060412705,0.09901642,-0.011559343,-0.019695476,0.009181307,0.013098153,-0.049380504,-0.037341837,0.03959026,-0.0055141808,-0.08832038,0.059819613,0.042381227,-0.039317414,0.098113924,-0.0325441,0.015588932,0.051180568,0.123099945,-0.028480688,0.08289687,-0.05802108,-0.07791917,-0.014590836,-0.04010224,-0.024484629,0.034198742,-0.08973618,9.3954106e-05,0.0048319628,-0.007135337,-0.06491593,-0.07164672,0.0041014636,-0.020468865,-0.0048646093,-0.03402048,-0.014489571,0.023970854,-0.074299574,-0.02160852,0.023310533,0.016668228,-0.039474797,0.090037085,-0.04664531,0.060221747,0.05835281,-0.05206555,-0.02244425,0.024491256,0.071849935,-0.030625233,-0.021087443,-0.040811565,-0.054319482,-0.016097303,0.023016851,-0.07018526,0.009026886,-0.039565776,0.028430779,0.014954204,0.0010352334,0.010944532,-0.032164503,-0.018683458,0.048419975,-0.042469017,0.0014899017,-0.020810528,0.05150577,-0.0026296722,-0.00884715,0.0505166,-0.056830365,0.067691326,0.022053778,-0.10321405,-0.0538491,0.004538305,0.05587948,0.046709508,0.08306765,-0.024001647,-0.0384922,-0.1337014,0.088401444,-0.02572032,0.040524453,-0.022029905,0.019421227,-0.010993662,-0.02727087,0.018769413,-0.015915742,-0.077441275,0.04130723,-0.08133127,0.0718422,-0.054680616,0.056784797,-0.009606944,-0.06435656,-0.07635962,0.00744762,0.003978297,-0.011408741,0.015102946,-0.0057537006,0.018099647,-0.0061748745,0.03272898,0.069261916,0.0058845216,-0.0025713267,0.014989733,-0.004228114,0.05205622,-0.0026679407,-0.055393063,0.038267307,-0.04996847,-0.09770224,0.032118384,-7.1639475e-34,0.05841243,0.10381546,0.044895284,0.0624173,-0.058408987,0.084315814,-0.0484664,-0.03332188,0.02412716,-0.02661737,0.0033307474,-0.062410492,0.017200667,0.033913728,0.048683126,-0.14971116,0.021229649,-0.026431022,0.080655135,-0.04873955,0.059519533,0.035531264,-0.0020676528,-0.0074908165,-0.05770358,0.08081117,-0.028241668,0.009227095,0.018702412,0.039029438,0.020965923,-0.019656487,-0.037403725,-0.055228565,0.027502047,0.039120946,-0.044212554,-0.047428537,-0.021039028,-0.010531438,-0.024407499,0.03544007,-0.09694866,-0.024670115,-0.018324574,-0.07179034,0.036607143,0.06970383,0.030849837,0.07003276,-0.0053930925,0.052110903,0.07791187,0.005462096,-0.012642633,0.02275819,-0.010304155,-0.048324008,0.02519482,0.063924804,0.0626058,0.009885993,0.012501716,0.0510577,-0.068664655,0.04343895,-0.012236792,0.016121069,-0.012297096,-0.0021210157,-0.06938487,0.07362139,0.06461386,-0.006003747,-0.011510255,-0.0029026987,-0.05858666,-0.07215756,0.058810737,-0.017007004,0.0034846575,-0.06354861,-0.0253717,0.021897424,0.022731839,-0.017746337,-0.021823423,0.008806094,0.05394825,-0.047474727,0.0137573425,-0.043390773,0.029154362,-0.082994014,0.054455735,-2.4161155e-34,-0.014195737,-0.0718742,-0.010806257,0.06985909,0.03920389,0.05977598,0.040455677,-0.112389594,-0.06295592,0.04418154,-0.0004156027,0.02244394,0.016045269,-0.038251106,0.050148003,0.013290346,-0.0661799,0.04687132,0.0648844,0.027702792,-0.0029073327,0.1237578,0.04144074,0.09312009,0.0028234294,0.039927486,-0.046164937,0.0011801299,0.008131356,0.06171399,0.062941216,0.015005858,-0.103732534,-0.08662015,-0.06788121,-0.028836424,-0.001562136,0.050091196,-0.015815953,-0.039836664,0.013529718,0.023907416,-0.01549037,0.1605826,-0.030886173,0.00841369,-0.014370387,0.026236176,0.06257649,0.10479247,-0.03628514,-0.081199065,-0.110691965,-0.07589982,-0.003115336,-0.0648983,0.07300865,-0.03513872,-0.009218595,0.042570006,0.0074040033,-0.024664266,0.0062943897,-0.057389293,0.08022398,-0.04534081,0.031465877,0.13557026,0.06832914,0.078610055,0.02525788,0.10850726,0.10252656,-0.09303516,0.025837854,-0.00808202,-0.0175572,0.007170376,-0.008954623,-0.037027992,-0.045662183,-0.02351984,0.024727657,-0.016372884,-0.0142566655,-0.09442157,0.04630112,-0.034304302,-0.07306289,0.019616093,-0.0750716,0.0024076207,0.078918405,0.05467998,-0.0027565039,-1.8126642e-08,-0.08050925,0.010130529,0.049432673,-0.020129232,0.0071261222,0.025264323,0.036105826,-0.05996495,0.0040671197,-0.052028347,0.0017699895,0.0790233,0.16072726,0.04275628,0.053195626,-0.044865057,0.05511907,0.11720408,-0.062657915,-0.06661379,-0.09723387,-0.06789632,-0.051061172,0.026112782,0.026207205,0.021803517,0.035006654,0.006111371,0.084354594,-0.029238822,0.026229862,-0.043917373,-0.003059834,-0.028853405,-0.10537471,-0.030031051,-0.023757808,0.00016009774,-0.03562493,-0.03339227,-0.011417447,-0.006316148,-0.013844411,0.038314328,-0.045274302,0.0023489755,-0.004488566,-0.06112775,-0.048164006,0.07229555,0.021424996,0.0033747712,0.025545679,0.0072756642,0.014615922,0.075033605,0.008413371,0.009344983,0.09265562,-0.03857441,0.07211084,-0.02583843,0.07285315,-0.04682338 +1.14.11.2,"Requires Fe2+ and ascorbate.The enzyme, which is located within the lumen of the endoplasmic reticulum, catalyses the 4-hydroxylation of prolines in -X-Pro-Gly- sequences. The 4-hydroxyproline residues are essential for the formation of the collagen triple helix. The enzyme forms a complex with protein disulfide isomerase and acts not only on procollagen but also on more than 15 other proteins that have collagen-like domains.",384,1.0,-0.07326549,-0.0991665,-0.054706585,0.013384303,0.06450555,-0.030353157,-0.039513092,0.08655866,0.0049275802,-0.043464344,0.038765896,0.095258825,-0.07680315,0.050388034,-0.06137638,-0.022327654,-0.07218215,-0.021399995,-0.021623148,-0.0751699,0.09505733,-0.0777564,0.04630539,-0.051982798,0.014845255,-0.06407829,0.058014754,-0.002739387,0.03343551,-0.06935721,0.018269315,-0.067857884,0.0012672936,-0.008662107,0.06572272,0.060436603,0.012813822,-0.06776914,-0.009779439,-0.018902244,0.08698127,-0.032798797,-0.031556785,-0.03071045,0.090285845,-0.07594407,0.070395544,0.0025315231,0.050673176,0.0891864,-0.055747636,-0.05755997,-0.051638685,0.06790621,-0.04259132,0.064697884,-0.05472669,-0.041757017,0.0087685175,0.044461403,-0.007426184,0.0133840805,-0.03762678,-0.04880436,0.048708376,-0.031743195,0.0062234644,0.019225061,-0.036894724,0.06857638,-0.008821034,0.014203611,-0.0012460976,0.009748884,0.0018218023,0.025625486,-0.05434898,-0.015898056,0.02349528,0.0047444636,0.06117799,0.038691886,0.06889786,0.100444585,0.021126304,0.043642614,-0.00042995156,-0.045373812,-0.036540054,0.051966365,-0.012711503,-0.013256466,-0.03821289,0.046937723,-0.046817966,0.07420838,0.06108358,-0.006604989,0.025332445,-0.026610931,-0.02521866,-0.025176134,0.09904179,-0.07168753,-0.014890266,0.00769358,-0.05878893,0.136172,0.013766209,0.0012071028,0.040012714,-0.013966875,0.030688407,0.016273726,0.02929334,0.08395832,0.01476965,-0.07187352,0.007121533,-0.050158314,-0.010846027,0.023636602,0.0691253,0.05546377,-0.100085296,0.03615736,-0.07195568,2.838713e-33,0.025338791,0.068841375,-0.0061185136,0.04592879,-0.07387364,0.027040957,-0.12308836,0.02699913,-0.07935887,0.0005038468,-0.063361615,-0.041682936,0.082935154,-0.013284241,0.00630345,-0.09540092,0.023971185,0.021060763,0.043017767,0.004938952,0.041724697,0.020018276,0.0001239123,-0.040337943,0.052002784,0.043103542,-0.027487198,0.012368597,0.042532273,0.0023622476,0.03337053,-0.108079456,0.010438138,0.042897493,0.093614615,0.040507507,-0.032263964,-0.0710435,-0.028098436,0.08169014,0.00238962,-0.023712924,0.024159117,-0.06996153,0.08196371,-0.05555334,0.03414724,0.06887341,-0.016470712,0.016339723,0.06202094,0.06673093,0.09333096,-0.031073788,-0.05210091,0.030026004,-0.05388634,-0.018213967,0.03702988,0.03573651,0.040380996,-0.0058966777,-0.06251513,0.06935849,-0.00876525,0.04158127,-0.06127198,0.022185255,-0.0057004313,0.08429693,-0.081451975,0.01287747,0.07833436,0.0031776493,0.031537846,-0.02339888,-0.07591422,0.06476551,0.0045989137,-0.0055753314,-0.030029068,0.03145616,-0.054172687,0.03599893,-0.018385129,0.020907866,0.02172398,-0.022200204,0.035998315,0.026194165,0.06269104,-0.040499702,-0.06579349,0.05363495,-0.007598945,-3.4446044e-33,0.057718076,-0.111768365,0.06501869,-0.046974376,-0.06991736,0.046174355,0.074414015,-0.06983912,0.03535512,0.056592338,0.07863502,-0.011168331,-0.013086205,-0.08835643,0.04848379,0.04913591,-0.10262922,-0.020422217,0.012004113,-0.055621054,0.04184691,0.061345123,0.072598375,0.055840585,0.014661016,0.0072253607,0.016999645,0.0070309057,0.020817159,0.10875619,-0.038593166,-0.023199294,-0.020177498,-0.06340007,-0.075011455,0.035128504,-0.07152705,0.020934027,0.031912602,-0.04887384,0.025557216,0.0106799705,-0.008202573,0.0698224,0.012600689,0.06631396,-0.042565826,0.08002821,0.01928405,0.022238225,-0.012523084,-0.059022587,-0.054922853,-0.007230482,0.00534468,0.028119171,0.015193719,0.028537678,-0.018714337,0.015088198,-0.054663457,-0.0605219,0.060721193,0.0033913408,0.09140476,0.00958464,-0.0514445,0.015610178,-0.015426983,0.016906988,0.07319313,0.02208691,-0.034720182,0.020326667,-0.009828753,0.013262206,-0.040229857,-0.023206897,-0.07444852,-0.030360483,-0.033179794,-0.02812673,0.016819749,-0.08642408,0.0008907922,-0.010990419,0.02679189,0.13822693,0.006085022,-0.012460998,0.027233962,-0.0207261,-0.061339825,0.0035916034,0.010744257,-4.1318135e-08,-0.09049756,-0.008257841,0.054691445,-0.12476592,-0.048800018,-0.015570823,0.08172308,-0.0066777077,0.032892525,-0.029885536,-0.03536744,0.07959894,-0.060246013,-0.043622915,0.0034892994,0.033767283,-0.011958561,0.042880714,-0.04900316,-0.090501055,-0.067340165,-0.05042696,-0.08229397,0.0997356,-0.0028794862,-0.039704952,-0.0015714011,0.048523743,-0.06447406,-0.014600948,0.02927908,-0.008953149,0.025384502,-0.05710334,-0.07492692,0.029383305,-0.011961229,-0.010937118,-0.048549935,0.003786391,0.010739598,-0.049031425,0.051743247,-0.028125426,-0.027830312,0.022134831,0.03493497,0.050431594,0.019385828,0.08953742,-0.047239915,-0.08499433,-0.03310624,-0.09948029,-0.0899417,-0.00613163,0.009687033,-0.06362583,-0.007573284,-0.05139513,0.025555829,0.01187158,0.18978979,-0.06008256 +1.14.11.3,"Requires iron(II) and ascorbate. Also acts on thymidine. cf. EC 1.14.11.10, pyrimidine-deoxynucleoside 1'-dioxygenase.",384,0.99999994,-0.046678625,-0.0064786216,-0.062108476,0.023757279,0.07635815,0.008571977,-0.038740803,0.031013435,-0.04280858,-0.014685408,0.01964441,-0.026925962,-0.06164105,0.06663217,0.009469996,-0.021057773,-0.014961027,-0.014232227,-0.025157545,-0.06209934,-0.037575714,0.032518815,0.049395394,-0.036738914,-0.01857176,-0.01731941,0.020607674,-0.0005804505,-0.032296117,-0.030415488,-0.0024604257,-0.10689823,0.041524038,-0.043893944,-0.014553854,0.10720183,-0.056333214,-0.027389502,0.035588842,0.03367662,0.019229928,-0.0421923,-0.075475454,0.008845529,-0.021817528,-0.0513416,0.041422006,-0.0046623405,-0.016820442,0.08974092,-0.05026835,0.106476404,-0.02897664,0.019219076,-0.06149904,0.03119073,-0.060522504,0.022524718,-0.0728648,0.020657228,-0.060809787,-0.07063026,-0.0020804738,0.011900557,0.009059164,0.0013894043,0.06693747,-0.0072287964,-0.013835842,-0.054726817,0.038051073,-0.060257494,-0.049727768,0.08344705,-0.03112997,0.010817121,-0.015142598,-0.08476198,0.07280504,-0.0066698953,-0.07127265,-0.05500349,0.0211884,0.027303552,0.052866478,0.036194816,-0.07589273,-0.022831412,-0.027071336,0.08983698,0.03266336,0.0007622641,-0.04241824,-0.003478792,0.06893052,0.035019886,0.068895,0.069350146,-0.03450759,-0.049036015,-0.061755877,0.008835921,-0.12648912,0.056483243,-0.0027372842,-0.048380528,0.009919263,-0.045965765,-0.019414674,-0.017526804,0.027494714,0.023121811,0.030023133,-0.011197576,0.028860651,0.066552155,0.06983455,-0.054709975,-0.017685067,0.021349812,0.072504856,-0.03214836,-0.016441608,0.10084952,-0.056221753,-0.02815564,0.02331732,1.4876878e-33,0.050377823,0.068148665,0.010922905,0.050432965,-0.012860273,0.08725724,-0.07620685,-0.02643833,-0.052203126,-0.037069745,-0.048925336,-0.08807258,0.09920602,0.021140842,-0.0680675,-0.08588029,-0.00030252893,-0.0027372057,0.1009828,-0.062887855,0.099488094,0.08432402,0.024780884,0.03672482,-0.08286651,0.04973768,-0.037858095,0.07126044,0.05585623,-0.0046379487,0.01626464,-0.12287924,-0.05317547,-0.016102942,0.028399877,0.018534627,-0.10135806,-0.019226328,-0.019256327,0.061097182,0.013324336,0.065395795,-0.068298906,-0.033744738,0.030026512,-0.067326315,-0.01082354,0.078983255,-0.027469423,0.081008226,0.021441221,0.009407535,0.116921805,-0.046196178,0.009183593,-0.001177536,-0.033210717,-0.050121844,0.053562216,0.10995075,0.05946217,-0.009929722,-0.00796312,0.031708762,0.06295176,-0.0067232,-0.077459924,0.021979863,-0.0014616967,0.023680072,-0.024069168,-0.017278805,0.032597277,-0.0063669207,0.04069658,0.010637133,-0.094338365,0.06620205,0.01192938,-0.06536232,-0.001636454,-0.013537301,0.0015937185,0.021024419,-0.017541567,0.012575787,-0.045634136,-0.03691271,0.056590635,-0.04795485,0.091175355,-0.058664195,-0.037787274,-0.07343785,0.072089516,-3.2036875e-33,0.05600854,-0.04205621,-0.00083248125,-0.03358698,-0.02385903,0.07529125,0.057624254,-0.10649479,0.018738413,0.014004571,0.06293625,-0.04713888,-0.054277983,-0.07219295,-0.044381153,0.052869383,-0.014820084,0.06996439,0.024084467,0.02210711,-0.012107212,0.05312018,0.007269902,0.12027883,0.056462064,-0.0041011805,-0.051145487,-0.00579265,0.06598166,0.01842955,-0.028259374,0.036544576,-0.044275485,-0.072606735,0.043933276,0.0078094364,-0.05534364,0.02875376,-0.03135091,-0.041003656,0.04232693,-0.008469301,0.02902201,0.13821922,0.00609855,0.024489986,-0.099984474,0.018025339,-0.023235856,-0.00045735994,-0.031793565,-0.046619616,-0.05563555,-0.013590191,0.098306224,-0.025424462,0.025134023,0.00819252,0.020121377,-0.009141731,-0.0025736187,-0.051998314,-0.007012313,-0.022379266,0.046483535,-0.0343632,-0.07405188,0.07874823,0.05974014,0.04410752,0.03225197,0.027705204,0.094644934,-0.104396984,-0.06499709,-0.014458341,-0.006470625,0.04965222,0.043186214,0.021137752,-0.023524987,-0.03733386,-0.039458305,-0.047921408,0.012492904,-0.084137276,0.028608002,0.008569558,-0.04943878,0.00031856852,-0.055633448,-0.096851476,0.011432462,0.08598786,0.050849915,-3.5469316e-08,-0.007947038,-0.018321663,0.044838525,-0.031013137,0.005967312,0.045395706,0.057170082,-0.056010623,0.018480636,-0.061939925,0.039998516,0.08701128,0.11744223,-0.013014121,0.062219687,0.0060274024,-0.043777727,0.08225325,0.010706254,-0.03475777,-0.08641892,-0.0194945,-0.09929346,0.021421084,0.061091058,-0.008033733,0.012042656,-0.007342528,0.10055603,-0.041270126,0.037412897,-0.058745835,0.020338574,-0.09717767,-0.05766013,-0.011482927,-0.008484882,0.03770269,-0.0068666553,-0.03979362,-0.07518355,0.038507283,-0.027895104,0.038503624,0.030047862,0.03229452,-0.025477601,0.05703243,-0.054720588,0.0062256916,0.043639027,-0.03131878,0.027764026,-0.022200674,-0.0842196,0.09544974,-0.010258101,-0.06645556,0.008198136,-0.06756055,0.020217728,0.05652015,0.1585079,-0.05039444 +1.14.11.4,Requires Fe2+ and ascorbate.,384,1.0,0.004124434,-0.051354267,-0.060412705,0.09901642,-0.011559343,-0.019695476,0.009181307,0.013098153,-0.049380504,-0.037341837,0.03959026,-0.0055141808,-0.08832038,0.059819613,0.042381227,-0.039317414,0.098113924,-0.0325441,0.015588932,0.051180568,0.123099945,-0.028480688,0.08289687,-0.05802108,-0.07791917,-0.014590836,-0.04010224,-0.024484629,0.034198742,-0.08973618,9.3954106e-05,0.0048319628,-0.007135337,-0.06491593,-0.07164672,0.0041014636,-0.020468865,-0.0048646093,-0.03402048,-0.014489571,0.023970854,-0.074299574,-0.02160852,0.023310533,0.016668228,-0.039474797,0.090037085,-0.04664531,0.060221747,0.05835281,-0.05206555,-0.02244425,0.024491256,0.071849935,-0.030625233,-0.021087443,-0.040811565,-0.054319482,-0.016097303,0.023016851,-0.07018526,0.009026886,-0.039565776,0.028430779,0.014954204,0.0010352334,0.010944532,-0.032164503,-0.018683458,0.048419975,-0.042469017,0.0014899017,-0.020810528,0.05150577,-0.0026296722,-0.00884715,0.0505166,-0.056830365,0.067691326,0.022053778,-0.10321405,-0.0538491,0.004538305,0.05587948,0.046709508,0.08306765,-0.024001647,-0.0384922,-0.1337014,0.088401444,-0.02572032,0.040524453,-0.022029905,0.019421227,-0.010993662,-0.02727087,0.018769413,-0.015915742,-0.077441275,0.04130723,-0.08133127,0.0718422,-0.054680616,0.056784797,-0.009606944,-0.06435656,-0.07635962,0.00744762,0.003978297,-0.011408741,0.015102946,-0.0057537006,0.018099647,-0.0061748745,0.03272898,0.069261916,0.0058845216,-0.0025713267,0.014989733,-0.004228114,0.05205622,-0.0026679407,-0.055393063,0.038267307,-0.04996847,-0.09770224,0.032118384,-7.1639475e-34,0.05841243,0.10381546,0.044895284,0.0624173,-0.058408987,0.084315814,-0.0484664,-0.03332188,0.02412716,-0.02661737,0.0033307474,-0.062410492,0.017200667,0.033913728,0.048683126,-0.14971116,0.021229649,-0.026431022,0.080655135,-0.04873955,0.059519533,0.035531264,-0.0020676528,-0.0074908165,-0.05770358,0.08081117,-0.028241668,0.009227095,0.018702412,0.039029438,0.020965923,-0.019656487,-0.037403725,-0.055228565,0.027502047,0.039120946,-0.044212554,-0.047428537,-0.021039028,-0.010531438,-0.024407499,0.03544007,-0.09694866,-0.024670115,-0.018324574,-0.07179034,0.036607143,0.06970383,0.030849837,0.07003276,-0.0053930925,0.052110903,0.07791187,0.005462096,-0.012642633,0.02275819,-0.010304155,-0.048324008,0.02519482,0.063924804,0.0626058,0.009885993,0.012501716,0.0510577,-0.068664655,0.04343895,-0.012236792,0.016121069,-0.012297096,-0.0021210157,-0.06938487,0.07362139,0.06461386,-0.006003747,-0.011510255,-0.0029026987,-0.05858666,-0.07215756,0.058810737,-0.017007004,0.0034846575,-0.06354861,-0.0253717,0.021897424,0.022731839,-0.017746337,-0.021823423,0.008806094,0.05394825,-0.047474727,0.0137573425,-0.043390773,0.029154362,-0.082994014,0.054455735,-2.4161155e-34,-0.014195737,-0.0718742,-0.010806257,0.06985909,0.03920389,0.05977598,0.040455677,-0.112389594,-0.06295592,0.04418154,-0.0004156027,0.02244394,0.016045269,-0.038251106,0.050148003,0.013290346,-0.0661799,0.04687132,0.0648844,0.027702792,-0.0029073327,0.1237578,0.04144074,0.09312009,0.0028234294,0.039927486,-0.046164937,0.0011801299,0.008131356,0.06171399,0.062941216,0.015005858,-0.103732534,-0.08662015,-0.06788121,-0.028836424,-0.001562136,0.050091196,-0.015815953,-0.039836664,0.013529718,0.023907416,-0.01549037,0.1605826,-0.030886173,0.00841369,-0.014370387,0.026236176,0.06257649,0.10479247,-0.03628514,-0.081199065,-0.110691965,-0.07589982,-0.003115336,-0.0648983,0.07300865,-0.03513872,-0.009218595,0.042570006,0.0074040033,-0.024664266,0.0062943897,-0.057389293,0.08022398,-0.04534081,0.031465877,0.13557026,0.06832914,0.078610055,0.02525788,0.10850726,0.10252656,-0.09303516,0.025837854,-0.00808202,-0.0175572,0.007170376,-0.008954623,-0.037027992,-0.045662183,-0.02351984,0.024727657,-0.016372884,-0.0142566655,-0.09442157,0.04630112,-0.034304302,-0.07306289,0.019616093,-0.0750716,0.0024076207,0.078918405,0.05467998,-0.0027565039,-1.8126642e-08,-0.08050925,0.010130529,0.049432673,-0.020129232,0.0071261222,0.025264323,0.036105826,-0.05996495,0.0040671197,-0.052028347,0.0017699895,0.0790233,0.16072726,0.04275628,0.053195626,-0.044865057,0.05511907,0.11720408,-0.062657915,-0.06661379,-0.09723387,-0.06789632,-0.051061172,0.026112782,0.026207205,0.021803517,0.035006654,0.006111371,0.084354594,-0.029238822,0.026229862,-0.043917373,-0.003059834,-0.028853405,-0.10537471,-0.030031051,-0.023757808,0.00016009774,-0.03562493,-0.03339227,-0.011417447,-0.006316148,-0.013844411,0.038314328,-0.045274302,0.0023489755,-0.004488566,-0.06112775,-0.048164006,0.07229555,0.021424996,0.0033747712,0.025545679,0.0072756642,0.014615922,0.075033605,0.008413371,0.009344983,0.09265562,-0.03857441,0.07211084,-0.02583843,0.07285315,-0.04682338 +1.14.11.6,Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil to oxidize its -CH2OH group first to -CHO and then to -COOH.,384,1.0,-0.0076025473,-0.079463765,-0.015383326,0.11908266,0.044859074,0.004700458,-0.028477268,-0.0084227845,-0.025490565,-0.063320756,0.064436994,-0.0617173,-0.10451689,0.028762486,-0.032112766,0.032605782,-0.03955874,-0.035725437,-0.035865337,-0.018155983,0.12930447,-0.058605533,0.0128175225,-0.012974944,-0.008942247,-0.012404632,0.002647425,0.0144935995,0.0009821382,-0.14207661,-0.00027939706,0.07446882,0.021604013,-0.05239201,-0.07764121,0.04127863,0.01657252,-0.035599545,0.053219672,0.03192556,-0.014139142,-0.06883262,0.00037391586,0.0055858563,-0.030978706,-0.09257587,0.06700742,-0.030885756,0.05974921,0.0017213713,-0.029723927,0.021962136,-0.052119415,0.024160776,-0.049675453,0.019352393,0.008669573,-0.039466348,0.0040987977,-0.025551748,-0.010635125,-0.019036286,-0.047679495,0.008567231,-0.048816934,-0.020870145,0.001861781,-0.07166746,-0.04699928,0.02403208,-0.029173667,-0.06836431,0.03836759,0.020462735,-0.026545642,0.04462713,0.017490283,-0.11083286,0.07611665,-0.035284333,-0.03009019,0.04050795,0.0021717015,0.07368054,0.1134119,0.066040814,-0.068415195,-0.084606804,-0.09345602,0.03158669,-0.045793753,0.052431278,-0.050407298,0.0022192544,-0.018904937,0.0014986015,0.11748125,-0.0023725473,0.0038323824,0.0032968326,-0.051816482,0.06196417,-0.07498876,-0.07264299,-0.0528332,-0.023746222,0.0014498349,0.05081285,0.022825781,-0.006091496,-0.017809879,0.011230192,-0.027381703,-0.065803,0.005986621,0.1164828,0.016657988,-0.04989842,-0.060449112,-0.03795908,0.032375578,-0.01381444,-0.07418717,0.0856803,-0.13012648,-0.01628994,0.011997024,2.3051527e-33,0.05497021,0.045046076,-0.017919574,0.03241551,-0.056986775,-0.021953842,-0.07964228,-0.05560843,0.036847547,-0.028571436,0.01407045,-0.040316954,0.019277884,0.0014121276,-0.035069037,-0.06763542,-0.048943404,-0.033651166,0.06274766,-0.033475872,0.07028127,0.10016891,-0.06620613,-0.025255278,-0.07454571,0.03485081,0.01619302,-0.0080111185,0.07361911,0.031799566,0.04532814,-0.0017401186,-0.057455685,-0.0075513986,0.024036769,0.033336703,-0.04960355,0.032401495,0.0014156334,0.03165597,0.04287181,0.072708115,-0.038047317,-0.028184406,0.06445909,-0.05189208,-0.03620399,0.10136253,0.05400642,0.11342672,-0.022698618,0.022656143,0.07091197,0.061496742,0.003115851,0.00021315696,0.005598572,-0.047760494,0.016911315,0.08821645,0.012748563,0.03653681,-0.022811085,0.021808896,-0.05475922,0.065461315,-0.014155076,0.0012465221,-0.0112809315,-0.010146407,-0.078587666,0.082370214,0.05339895,0.06300964,-0.0038393105,-0.0022726334,0.0025494515,-0.016694214,0.042811405,0.041821793,0.0053531006,-0.032714736,0.0018850402,-0.0110441875,-0.048046842,0.04262759,0.021146046,0.0067702876,-0.015896482,-0.0020713236,0.106562555,-0.09779937,0.064225905,-0.037984844,0.03131919,-4.294381e-33,0.07520133,-0.07403411,0.032576393,-0.04287423,-0.013728674,0.027012538,0.0365768,-0.11106047,-0.027792543,0.02381175,0.04870474,0.039579097,-0.026827771,-0.038234442,0.03488115,-0.0045116046,-0.028253915,0.073730044,0.04512419,0.056879345,0.02432088,0.12446394,0.010400075,0.09474,0.10219327,0.051998664,-0.039269798,-0.056044374,0.031583138,0.07409742,-0.00024115141,-0.026393013,-0.023363402,-0.07875295,-0.012645704,-0.0035446645,-0.0696252,0.056220226,-0.057583913,0.009718729,-0.037709173,-0.004169035,0.0070434515,0.10091891,0.012753225,0.06689715,-0.07246374,-0.02651995,0.014573696,0.058612984,0.035312556,-0.036032807,-0.13252874,-0.06412802,0.012707935,0.0285914,0.06806578,-0.0051005026,0.0024963021,-0.025266726,-0.054895177,-0.017522251,0.07709313,-0.115518354,0.009531869,-0.0047915378,-0.013557899,0.037942547,0.07522803,0.017617378,-0.023687866,0.090424664,0.09796551,-0.01059888,0.023487475,-0.08234491,-0.029372707,-0.015483073,-0.05301335,0.022433471,-0.025214544,0.029649919,-0.0014543124,-0.03527121,0.00027444033,-0.086621776,-0.01690436,0.05672685,0.019075181,0.03770053,-0.03885614,0.018581765,0.028334988,0.019802785,0.05800735,-3.4960983e-08,-0.06131447,-0.015217765,0.071499646,-0.009191836,0.005047308,0.04377966,0.016431127,-0.06442406,0.06743247,-0.099166326,0.009372116,0.14893973,0.10057964,0.0045075365,-0.0052119084,-0.097454935,-0.024003701,0.060823783,-0.0062076445,-0.07183793,-0.12710367,-0.06038093,-0.075028494,0.010716093,0.041954316,-0.041402176,0.034699656,0.019927977,0.02368001,-0.014900433,0.03348807,0.0069002886,-0.06499546,-0.00470421,-0.06361245,0.023520984,-0.018345516,0.00017485979,-0.098699026,-0.016896237,-0.019244026,7.9597216e-05,-0.03790086,0.042833418,0.0534874,0.0032462173,-0.041323002,0.0025372608,0.010476916,0.060373656,0.01868305,-0.08913599,-0.010778091,-0.034720786,-0.06225957,0.039304897,-0.008950842,-0.019442545,0.011278364,-0.067378245,0.020461114,0.0311935,0.13117462,-0.013143924 +1.14.11.7,"Requires Fe2+ and ascorbate. The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum. It modifies proline residues within the procollagen peptide of certain collagen types. The modification is essential for proper collagen triple helix formation. ",384,1.0,-0.06914386,-0.057551537,-0.05277415,0.053899333,0.07228199,-0.024007022,-0.048724357,0.063594885,0.021937482,-0.0355439,0.029033152,0.07880145,-0.10759517,0.08055915,-0.042314023,-0.047259677,-0.045624275,0.015265756,-0.0026297455,-0.05979922,0.096321695,-0.02805882,0.027381701,-0.06157451,-0.020020863,-0.06886265,0.040967554,0.008270826,0.0350325,-0.08772972,0.010380678,-0.10533647,0.028191563,0.0122734895,0.026987618,0.0633659,0.008420128,-0.024478061,0.028301787,-0.007593651,0.048651487,-0.05613544,-0.041800305,-0.005708304,0.076701604,-0.07016491,0.04780274,0.007984964,0.021509418,0.08544804,-0.09986923,-0.032286394,-0.006491872,0.06641136,-0.057284057,0.06456637,-0.03174167,-0.021644495,-0.018106055,0.010156958,0.022095041,0.0006302004,-0.03225162,-0.044588983,0.039345045,-0.006291417,0.024111638,0.051925756,-0.0013045156,0.014749608,0.018159512,0.008684854,-0.0032968891,0.0151089365,0.013880921,0.0037468644,-0.06250152,0.010427009,0.03785679,0.026725108,0.07572252,0.044636887,0.057545617,0.10960517,0.035637602,0.06428918,-0.012235403,-0.047246538,-0.04795124,0.03116328,-0.0103918975,0.0008531661,-0.06377724,0.012608316,-0.022767285,0.04859092,0.025260193,0.04847931,0.043366723,0.017528685,-0.012312786,0.0029079062,0.052314054,-0.049491003,-0.017807974,-0.021425387,-0.073911935,0.088359445,0.039217968,0.004577459,0.06364524,0.019640518,0.011195774,-0.005544406,0.04908831,0.06846642,0.034921344,-0.06791366,0.0014943734,-0.024283288,0.028323032,0.01864549,0.03920587,0.06654178,-0.108952075,0.06059176,-0.11523791,4.6288356e-33,0.012607127,0.076143175,-0.0071765673,0.08408006,-0.09158107,0.014420121,-0.11354427,-0.0030542167,-0.037362102,-0.023503438,-0.06140401,-0.06077044,0.07149162,-0.0052684136,0.030622147,-0.07934377,-0.007093935,0.020330915,0.06721979,-0.037439022,0.08231669,0.074937806,-0.021803346,-0.035162147,0.036132473,0.05860305,-0.027711032,0.02359072,0.042135287,-0.017718604,0.06994129,-0.08122617,-0.011032004,0.007102793,0.12958209,0.011930267,-0.021219756,-0.062082272,-0.04871717,0.026461374,0.028292995,0.0030857194,0.0038279758,-0.054848757,0.08645092,-0.08758305,0.043117315,0.083037876,-0.018530525,0.0089719035,0.05704958,0.056319457,0.08515429,-0.061587106,-0.03398022,0.011854127,-0.044035725,-0.058890484,0.03142517,0.05311757,0.04826347,-0.048399765,-0.04752022,0.06941104,-0.011913585,0.034651607,-0.06521366,0.03432225,0.0054231337,0.10889694,-0.0906527,0.015056229,0.011996534,0.00800929,0.0044490746,-0.02888584,-0.101310484,0.06496626,-0.017061006,-0.030297784,-0.03701295,-0.00851234,-0.061713595,0.03618875,-0.023179047,-0.012822041,0.018071566,-0.018313885,0.06477496,-0.025113558,0.06651833,-0.013265561,-0.08459971,0.0593998,0.041559916,-4.543318e-33,0.046032846,-0.12717424,0.04097334,-0.055850517,-0.08946198,0.045013297,0.07940263,-0.05355048,0.038622316,0.048599053,0.06167986,-0.038336787,-0.02375234,-0.11218572,0.023674322,0.06615059,-0.09982544,0.006900405,0.045034446,-0.04260972,-0.0005970119,0.0875163,0.0843173,0.057586197,0.035745982,0.031945847,-0.039814662,0.02435662,0.043185856,0.07955327,-0.022142377,-0.026165377,-0.026630048,-0.051949885,-0.08654236,0.048773363,-0.08034649,-0.0030061794,0.019418078,-0.04396405,0.021619871,0.0066887066,-0.032877356,0.112835154,0.022233566,0.05424114,-0.045877293,0.062399272,0.005613691,-0.0058036856,-0.0026342934,-0.09890358,-0.046230618,-0.017794903,0.03471351,0.024922293,0.033185042,0.028449766,-0.009108653,0.025987988,-0.062931314,-0.03573366,0.036813308,0.0072440347,0.09632308,-0.025667036,-0.06168658,0.06909316,-0.021136483,0.020928627,0.06167332,0.034201317,0.021103181,-0.0043194126,-0.0033587662,-0.0061134216,-0.029451504,0.041403905,-0.07529362,-0.011736083,-0.074524865,-0.028979853,-0.025380807,-0.067691796,-0.01693642,0.034287468,0.029417366,0.103170805,-0.003041393,-0.007210389,-0.010985816,-0.0056028985,-0.0429773,0.01776823,-0.021235174,-3.7490544e-08,-0.056935754,-0.016952572,0.035873614,-0.1378826,-0.063628316,-0.028505424,0.07484003,-0.0068564406,-0.027906982,0.009288339,-0.03358351,0.1095246,0.0048429896,-0.046812493,0.010543201,0.020086061,0.012413224,0.07358339,-0.040191196,-0.0799665,-0.05126906,-0.051385123,-0.07725279,0.10544913,0.031883895,-0.033861473,0.005390984,0.035390805,-0.06951687,0.0062491065,0.022197394,-0.013439993,0.022351168,-0.039359428,-0.07935689,0.07192762,-0.02759931,-0.045527168,-0.052775897,0.00021203188,0.0062887655,-0.04526293,0.024019012,-0.010160795,-0.01220126,0.017425036,0.05544719,0.051150262,0.0065577542,0.06272341,-0.053225394,-0.07464772,-0.049234487,-0.076890714,-0.089983046,0.0062868665,0.005015092,-0.059396688,0.030469457,-0.044184368,0.049895935,0.0016249254,0.15668586,-0.064188175 +1.14.11.8,Requires Fe2+ and ascorbate.,384,1.0,0.004124434,-0.051354267,-0.060412705,0.09901642,-0.011559343,-0.019695476,0.009181307,0.013098153,-0.049380504,-0.037341837,0.03959026,-0.0055141808,-0.08832038,0.059819613,0.042381227,-0.039317414,0.098113924,-0.0325441,0.015588932,0.051180568,0.123099945,-0.028480688,0.08289687,-0.05802108,-0.07791917,-0.014590836,-0.04010224,-0.024484629,0.034198742,-0.08973618,9.3954106e-05,0.0048319628,-0.007135337,-0.06491593,-0.07164672,0.0041014636,-0.020468865,-0.0048646093,-0.03402048,-0.014489571,0.023970854,-0.074299574,-0.02160852,0.023310533,0.016668228,-0.039474797,0.090037085,-0.04664531,0.060221747,0.05835281,-0.05206555,-0.02244425,0.024491256,0.071849935,-0.030625233,-0.021087443,-0.040811565,-0.054319482,-0.016097303,0.023016851,-0.07018526,0.009026886,-0.039565776,0.028430779,0.014954204,0.0010352334,0.010944532,-0.032164503,-0.018683458,0.048419975,-0.042469017,0.0014899017,-0.020810528,0.05150577,-0.0026296722,-0.00884715,0.0505166,-0.056830365,0.067691326,0.022053778,-0.10321405,-0.0538491,0.004538305,0.05587948,0.046709508,0.08306765,-0.024001647,-0.0384922,-0.1337014,0.088401444,-0.02572032,0.040524453,-0.022029905,0.019421227,-0.010993662,-0.02727087,0.018769413,-0.015915742,-0.077441275,0.04130723,-0.08133127,0.0718422,-0.054680616,0.056784797,-0.009606944,-0.06435656,-0.07635962,0.00744762,0.003978297,-0.011408741,0.015102946,-0.0057537006,0.018099647,-0.0061748745,0.03272898,0.069261916,0.0058845216,-0.0025713267,0.014989733,-0.004228114,0.05205622,-0.0026679407,-0.055393063,0.038267307,-0.04996847,-0.09770224,0.032118384,-7.1639475e-34,0.05841243,0.10381546,0.044895284,0.0624173,-0.058408987,0.084315814,-0.0484664,-0.03332188,0.02412716,-0.02661737,0.0033307474,-0.062410492,0.017200667,0.033913728,0.048683126,-0.14971116,0.021229649,-0.026431022,0.080655135,-0.04873955,0.059519533,0.035531264,-0.0020676528,-0.0074908165,-0.05770358,0.08081117,-0.028241668,0.009227095,0.018702412,0.039029438,0.020965923,-0.019656487,-0.037403725,-0.055228565,0.027502047,0.039120946,-0.044212554,-0.047428537,-0.021039028,-0.010531438,-0.024407499,0.03544007,-0.09694866,-0.024670115,-0.018324574,-0.07179034,0.036607143,0.06970383,0.030849837,0.07003276,-0.0053930925,0.052110903,0.07791187,0.005462096,-0.012642633,0.02275819,-0.010304155,-0.048324008,0.02519482,0.063924804,0.0626058,0.009885993,0.012501716,0.0510577,-0.068664655,0.04343895,-0.012236792,0.016121069,-0.012297096,-0.0021210157,-0.06938487,0.07362139,0.06461386,-0.006003747,-0.011510255,-0.0029026987,-0.05858666,-0.07215756,0.058810737,-0.017007004,0.0034846575,-0.06354861,-0.0253717,0.021897424,0.022731839,-0.017746337,-0.021823423,0.008806094,0.05394825,-0.047474727,0.0137573425,-0.043390773,0.029154362,-0.082994014,0.054455735,-2.4161155e-34,-0.014195737,-0.0718742,-0.010806257,0.06985909,0.03920389,0.05977598,0.040455677,-0.112389594,-0.06295592,0.04418154,-0.0004156027,0.02244394,0.016045269,-0.038251106,0.050148003,0.013290346,-0.0661799,0.04687132,0.0648844,0.027702792,-0.0029073327,0.1237578,0.04144074,0.09312009,0.0028234294,0.039927486,-0.046164937,0.0011801299,0.008131356,0.06171399,0.062941216,0.015005858,-0.103732534,-0.08662015,-0.06788121,-0.028836424,-0.001562136,0.050091196,-0.015815953,-0.039836664,0.013529718,0.023907416,-0.01549037,0.1605826,-0.030886173,0.00841369,-0.014370387,0.026236176,0.06257649,0.10479247,-0.03628514,-0.081199065,-0.110691965,-0.07589982,-0.003115336,-0.0648983,0.07300865,-0.03513872,-0.009218595,0.042570006,0.0074040033,-0.024664266,0.0062943897,-0.057389293,0.08022398,-0.04534081,0.031465877,0.13557026,0.06832914,0.078610055,0.02525788,0.10850726,0.10252656,-0.09303516,0.025837854,-0.00808202,-0.0175572,0.007170376,-0.008954623,-0.037027992,-0.045662183,-0.02351984,0.024727657,-0.016372884,-0.0142566655,-0.09442157,0.04630112,-0.034304302,-0.07306289,0.019616093,-0.0750716,0.0024076207,0.078918405,0.05467998,-0.0027565039,-1.8126642e-08,-0.08050925,0.010130529,0.049432673,-0.020129232,0.0071261222,0.025264323,0.036105826,-0.05996495,0.0040671197,-0.052028347,0.0017699895,0.0790233,0.16072726,0.04275628,0.053195626,-0.044865057,0.05511907,0.11720408,-0.062657915,-0.06661379,-0.09723387,-0.06789632,-0.051061172,0.026112782,0.026207205,0.021803517,0.035006654,0.006111371,0.084354594,-0.029238822,0.026229862,-0.043917373,-0.003059834,-0.028853405,-0.10537471,-0.030031051,-0.023757808,0.00016009774,-0.03562493,-0.03339227,-0.011417447,-0.006316148,-0.013844411,0.038314328,-0.045274302,0.0023489755,-0.004488566,-0.06112775,-0.048164006,0.07229555,0.021424996,0.0033747712,0.025545679,0.0072756642,0.014615922,0.075033605,0.008413371,0.009344983,0.09265562,-0.03857441,0.07211084,-0.02583843,0.07285315,-0.04682338 +1.14.11.9,"Requires Fe2+ and ascorbate. This plant enzyme catalyses an early step in the flavonoid biosynthesis pathway, leading to the production of flavanols and anthocyanins. Substrates include (2S)-naringenin, (2S)-eriodictyol, (2S)-dihydrotricetin and (2S)-pinocembrin. Some enzymes are bifuctional and also catalyse EC 1.14.20.6, flavonol synthase.",384,1.0,-0.020901715,-0.035116967,-0.13792343,0.12619588,0.09963289,0.05144901,-0.06399797,0.0024389823,0.0137247145,-0.05587687,-0.0049173003,-0.040260967,-0.11377016,-0.064086035,-0.067470975,-0.0020335538,-0.06481255,0.063212916,-0.0324935,-0.008643716,0.10022657,-0.07277368,0.043509368,-0.040048733,-0.004680737,-0.028351668,0.013258267,-0.07737417,-0.009772046,-0.115284264,0.03651443,-0.011162389,0.10038384,-0.042712517,-0.0638374,0.049238212,0.023126174,-0.06810175,0.048903704,-0.0026582289,0.030333845,-0.025400762,0.002485564,-0.061665308,0.022972919,-0.04921173,0.02229814,0.024748236,0.027474914,0.017318176,-0.06587102,0.025994325,-0.049126968,-0.029393725,0.01306386,0.038339127,-0.00023968838,0.01377954,-0.0053860922,0.072916664,0.08082193,-0.023546182,-0.036257375,-0.01772566,-0.032132026,-0.040356144,-0.051939204,-0.0043122973,0.026761144,0.0147617785,-0.003292165,-0.03389392,-0.02846946,0.012241709,-0.028701058,0.0955436,-0.0071812943,0.043691795,0.028985713,-0.014556717,0.015604258,-0.03442895,0.016543312,0.020211836,0.016827328,0.037675437,-0.07408571,0.048252646,0.017982632,0.15285102,0.037972305,0.043082815,0.025984328,0.0069255168,-0.013076771,0.037288588,0.11065587,0.013104263,0.00061501947,-0.035535924,-0.018700147,0.011444596,0.052045014,-0.048041567,-0.015902165,-0.011454516,-0.06273169,-0.025799671,0.074265294,-0.006880127,0.04620837,-0.026197445,-0.01446115,-0.07656737,-0.0021577051,0.0936925,-0.028846871,-0.06563537,-0.04480035,0.027998779,0.008755852,0.024660187,-0.0021196075,0.07648536,-0.039205715,-0.028718669,-0.08497811,5.027577e-33,0.06311228,0.052427,-0.0831359,-0.001457357,0.0038757625,0.0054545607,-0.035563987,0.0008215259,0.014764239,-0.058615528,-0.088891074,-0.055733386,0.029689386,-0.02778046,-0.009220482,-0.062488783,0.010814364,-0.08058612,0.09985689,-0.0034147694,0.009936228,-0.054195695,-0.113785274,0.013965423,-0.024014972,0.036160406,-0.0025245668,-0.00803924,-0.0055728597,-0.0005759829,0.040201508,-0.112874344,-0.031485837,0.029759662,0.05299758,-0.040663134,-0.033785574,-0.047718517,-0.047653325,0.021710915,-0.0068095652,0.0046723248,-0.0032330006,0.0057082064,0.033738177,-0.025183486,-0.046761937,0.08655406,0.11146974,0.11271656,-0.0062488248,-0.00089774514,0.13715552,0.06639494,-0.009215708,0.018965352,-0.04881025,-0.043420073,0.03763535,0.07410932,0.01655271,0.02357945,-0.0038611242,0.015146759,-0.07745053,0.07807805,-0.04392324,-0.020867234,0.051087234,0.023626879,-0.013575875,-0.049569033,0.08124784,0.035371736,0.08705968,0.028369812,-0.05652871,-0.025631076,0.038508445,0.051638324,-0.025147984,0.05261527,0.0015968767,0.042015985,-0.025992215,0.01242341,-0.09174663,0.018149069,0.002249739,0.07610799,0.023303077,-0.05953884,-0.032147326,0.033267647,0.06257936,-4.9386044e-33,0.07720166,-0.061458286,-0.0006763662,-0.040989324,-0.068581425,0.01536689,0.016349977,-0.11843038,-0.01917512,0.021553269,0.0003690583,-0.04331187,0.06336098,-0.02810313,-0.012072097,-0.0049018026,0.02234385,0.10262907,0.03719035,0.020175885,-0.054890137,0.07612749,-0.022479711,0.05318238,0.03432992,-0.013372995,0.016190965,-0.030266738,-0.012679534,0.08794009,0.010114779,-0.008315723,-0.055670492,-0.029386293,0.0025901482,0.06049697,-0.02558845,0.0015625268,-0.031004528,0.013299746,-0.020753803,0.033725593,-0.017295446,0.05914158,0.03385951,0.015619345,-0.06929149,0.05554708,-0.03523234,-0.0022874414,0.025295705,0.05615628,-0.0625333,0.041355833,0.0053963554,-0.01419268,0.04414345,0.045977406,-0.02318347,0.0014699746,-0.052977085,-0.13352776,0.05121895,-0.048467904,0.08779342,0.066317014,0.0097402325,0.14880721,0.003426748,0.018085258,0.11464003,-0.0025044156,0.04341521,0.092800975,-0.027897345,-0.005278773,-0.015612345,-0.04526559,-0.034771446,-0.018118937,0.04293421,0.019476345,0.020441024,-0.055466954,-0.062878996,-0.06760965,0.04045687,0.008121959,-0.04081273,0.053377338,-0.0048275576,-0.033782262,-0.06628674,0.039560895,0.04417386,-4.1802906e-08,-0.08139354,-0.045646165,0.037855115,-0.01959016,0.07485046,0.028653184,-0.027048772,0.016013077,-0.01789823,-0.042214535,-0.05499489,0.096971355,0.02221814,0.047043238,0.069265924,-0.04599754,0.07405496,0.09535409,-0.007243755,0.020400887,-0.053331204,0.0020784237,-0.17144117,-0.05652652,0.010701443,-0.11148429,-0.0065488196,0.014329456,0.12742516,-0.0040026815,0.044981256,-0.007090693,-0.014742569,-0.015976958,-0.099136166,-0.044514537,-0.013605228,-0.072370626,-0.0483132,-0.031030642,-0.059729382,0.0037620447,0.05169157,0.022030294,-0.050478306,-0.013728236,-0.004204809,0.016977033,0.011417962,0.005238378,0.03592563,-0.05107895,0.02990549,-0.07858971,-0.02542632,-0.02187979,0.030412316,-0.011401428,0.0070342477,0.014050167,-0.041840304,0.057536274,0.15734513,-0.040280104 +1.14.11.10,"Requires iron(II) and ascorbate. cf. EC 1.14.11.3, pyrimidine-deoxynucleoside 2'-dioxygenase.",384,1.0,-0.04572365,-0.018052645,-0.08894402,0.04237587,0.042037718,-0.027123932,-0.06500825,0.04843026,-0.044955518,-0.038747363,0.02455967,-0.053006966,-0.08205014,0.047920663,-0.015900936,-0.0063519757,0.004511039,-0.014235294,-0.010155182,-0.034593884,0.003577854,0.02976811,0.0606233,-0.028727219,-0.012937908,0.0022828605,0.02335346,0.009920244,-0.04569597,-0.039580178,0.039280374,-0.1074634,0.043481212,-0.044889577,0.035936534,0.089698024,-0.060601495,-0.041485682,0.025284821,0.045015834,0.01061207,-0.011970841,-0.04278933,0.043500785,-0.010997692,-0.053744454,0.034703463,0.0023097964,0.012592561,0.080406934,-0.052068792,0.08406407,-0.047644272,0.004624082,-0.020806713,0.015525123,-0.058590554,0.002052493,-0.08860576,0.025870414,-0.059234094,-0.041198157,-0.015639054,0.009677057,-0.02107322,-0.006000515,0.06785208,-0.009114774,-0.0010694026,-0.021213068,0.009038543,-0.041568708,-0.06256159,0.076698385,-0.027475273,0.034890857,0.010855502,-0.07848946,0.065951206,-0.029803662,-0.038780015,-0.062407,0.0032370535,0.045221858,0.060808513,0.035848387,-0.06836779,-0.01712042,-0.046221707,0.09346768,0.010730475,0.012525104,-0.03707766,0.015933847,0.05249896,0.025846027,0.086139664,0.09060582,-0.04774551,-0.050010335,-0.054868463,0.009034938,-0.09571138,0.03125817,-0.018259509,-0.05846403,0.0015969516,-0.023922402,0.016019575,-0.036076393,0.05667368,0.02594701,0.037798543,-0.01060037,0.061674975,0.10816262,0.057634074,-0.059856758,-2.9432991e-05,0.040345643,0.05482963,-0.009984249,-0.02162244,0.067121066,-0.05312796,-0.038397815,0.029142397,1.4845215e-33,0.03464392,0.0769731,0.01827992,0.07690488,-0.04216247,0.10324642,-0.10747137,-0.035020825,-0.066772245,-0.029220987,-0.06325733,-0.08735722,0.08844995,0.01743203,-0.05143928,-0.09680418,0.026949652,-0.02777869,0.114634246,-0.044759676,0.07052557,0.038360808,-0.0037946464,0.042553592,-0.06859656,0.0730172,-0.013082436,0.048027206,0.06764579,4.4738692e-05,0.04151752,-0.11674216,-0.06767432,-0.036561817,-0.0037117961,-0.009358744,-0.08231478,-0.030837698,-0.049951825,0.038999226,-0.0010319158,0.07013625,-0.047229614,-0.06380014,0.04867851,-0.08419684,-0.013676893,0.1328349,-0.0015909292,0.102700494,0.013851327,0.035935417,0.12682849,-0.025646027,-0.01359875,-0.0015689898,-0.040409308,-0.0212843,0.075192764,0.10805002,0.06657397,0.037688535,-0.023758305,0.048889343,0.06709586,0.0049303276,-0.059265245,0.027786827,-0.009054506,0.05931299,-0.022799885,-0.037223056,0.051334698,-0.010840945,0.01672077,-0.0057241376,-0.08037852,0.07080876,0.0046411213,-0.051361185,-0.028890235,0.0009311329,-0.015183538,-0.004360359,-0.0076400256,0.03061479,-0.03241704,0.0022262896,0.05646336,-0.0029982578,0.049784604,-0.070877455,-0.04166639,-0.06230837,0.07145533,-3.3725003e-33,0.053706013,-0.04531773,-0.0063806693,-0.030230666,-0.008305666,0.0729006,0.083497934,-0.094847456,0.020568443,-0.0056509115,0.077295415,-0.04974292,-0.008504044,-0.08832448,8.130607e-06,0.039225478,-0.071473636,0.08239314,0.06374813,0.031454552,0.02048831,0.094416715,-0.01615895,0.12252226,0.040734835,0.010402132,-0.06363088,-0.020136816,0.040456325,0.033512607,-0.039695878,0.03853068,-0.07053212,-0.06960437,0.0026605083,0.031462148,-0.07819657,0.022280786,-0.049511734,-0.0046857456,0.0029365139,0.02997389,0.009693383,0.14191207,0.004494561,0.040871747,-0.097302474,0.014759605,0.0239031,0.012920171,-0.05084408,-0.03904089,-0.07805947,-0.018243507,0.07460336,-0.04159879,0.020647686,0.008255044,0.035954174,-0.028360909,-0.037286133,-0.07112785,0.0067448225,-0.035636682,0.03837123,-0.03412022,-0.06409104,0.08261624,0.029214898,0.018604789,0.03131133,0.020095488,0.08610654,-0.05761373,-0.050260082,-0.0169765,-0.024919385,0.073589705,0.027961936,0.021149114,-0.023295075,-0.030731454,0.0095891245,-0.001628672,0.008577611,-0.1129541,0.012566119,-0.014911631,-0.051948667,-0.010269986,-0.047558174,-0.09645084,0.010862719,0.0639824,0.048188504,-3.4584776e-08,-0.017869683,-0.014087507,0.04296632,-0.05166024,0.026285594,0.050286833,0.017032497,-0.0126787005,0.007469332,-0.06679597,0.046687044,0.074975714,0.08917394,0.013127223,0.04845895,0.006631358,-0.043156777,0.07504892,0.01655206,-0.031095486,-0.09144146,-0.03550057,-0.093226604,0.018862443,0.027260866,-0.017338336,0.007917601,-0.03246785,0.097217456,-0.032997116,0.027136872,-0.034767378,0.02869652,-0.106731325,-0.08763959,-0.016781345,-0.026605796,0.047212474,-0.017404506,-0.02023127,-0.082764536,-0.017778972,-0.026743276,0.038916457,0.040512487,0.013813434,-0.011260015,0.03470176,-0.07447395,0.017602181,0.049060926,-0.05788447,0.03327307,-0.01352588,-0.0689643,0.07922243,-0.033038087,-0.05829446,-0.01335183,-0.07245451,0.05327639,0.03146534,0.13601395,-0.05723621 +1.14.11.11,Requires Fe2+ and ascorbate.,384,1.0,0.004124434,-0.051354267,-0.060412705,0.09901642,-0.011559343,-0.019695476,0.009181307,0.013098153,-0.049380504,-0.037341837,0.03959026,-0.0055141808,-0.08832038,0.059819613,0.042381227,-0.039317414,0.098113924,-0.0325441,0.015588932,0.051180568,0.123099945,-0.028480688,0.08289687,-0.05802108,-0.07791917,-0.014590836,-0.04010224,-0.024484629,0.034198742,-0.08973618,9.3954106e-05,0.0048319628,-0.007135337,-0.06491593,-0.07164672,0.0041014636,-0.020468865,-0.0048646093,-0.03402048,-0.014489571,0.023970854,-0.074299574,-0.02160852,0.023310533,0.016668228,-0.039474797,0.090037085,-0.04664531,0.060221747,0.05835281,-0.05206555,-0.02244425,0.024491256,0.071849935,-0.030625233,-0.021087443,-0.040811565,-0.054319482,-0.016097303,0.023016851,-0.07018526,0.009026886,-0.039565776,0.028430779,0.014954204,0.0010352334,0.010944532,-0.032164503,-0.018683458,0.048419975,-0.042469017,0.0014899017,-0.020810528,0.05150577,-0.0026296722,-0.00884715,0.0505166,-0.056830365,0.067691326,0.022053778,-0.10321405,-0.0538491,0.004538305,0.05587948,0.046709508,0.08306765,-0.024001647,-0.0384922,-0.1337014,0.088401444,-0.02572032,0.040524453,-0.022029905,0.019421227,-0.010993662,-0.02727087,0.018769413,-0.015915742,-0.077441275,0.04130723,-0.08133127,0.0718422,-0.054680616,0.056784797,-0.009606944,-0.06435656,-0.07635962,0.00744762,0.003978297,-0.011408741,0.015102946,-0.0057537006,0.018099647,-0.0061748745,0.03272898,0.069261916,0.0058845216,-0.0025713267,0.014989733,-0.004228114,0.05205622,-0.0026679407,-0.055393063,0.038267307,-0.04996847,-0.09770224,0.032118384,-7.1639475e-34,0.05841243,0.10381546,0.044895284,0.0624173,-0.058408987,0.084315814,-0.0484664,-0.03332188,0.02412716,-0.02661737,0.0033307474,-0.062410492,0.017200667,0.033913728,0.048683126,-0.14971116,0.021229649,-0.026431022,0.080655135,-0.04873955,0.059519533,0.035531264,-0.0020676528,-0.0074908165,-0.05770358,0.08081117,-0.028241668,0.009227095,0.018702412,0.039029438,0.020965923,-0.019656487,-0.037403725,-0.055228565,0.027502047,0.039120946,-0.044212554,-0.047428537,-0.021039028,-0.010531438,-0.024407499,0.03544007,-0.09694866,-0.024670115,-0.018324574,-0.07179034,0.036607143,0.06970383,0.030849837,0.07003276,-0.0053930925,0.052110903,0.07791187,0.005462096,-0.012642633,0.02275819,-0.010304155,-0.048324008,0.02519482,0.063924804,0.0626058,0.009885993,0.012501716,0.0510577,-0.068664655,0.04343895,-0.012236792,0.016121069,-0.012297096,-0.0021210157,-0.06938487,0.07362139,0.06461386,-0.006003747,-0.011510255,-0.0029026987,-0.05858666,-0.07215756,0.058810737,-0.017007004,0.0034846575,-0.06354861,-0.0253717,0.021897424,0.022731839,-0.017746337,-0.021823423,0.008806094,0.05394825,-0.047474727,0.0137573425,-0.043390773,0.029154362,-0.082994014,0.054455735,-2.4161155e-34,-0.014195737,-0.0718742,-0.010806257,0.06985909,0.03920389,0.05977598,0.040455677,-0.112389594,-0.06295592,0.04418154,-0.0004156027,0.02244394,0.016045269,-0.038251106,0.050148003,0.013290346,-0.0661799,0.04687132,0.0648844,0.027702792,-0.0029073327,0.1237578,0.04144074,0.09312009,0.0028234294,0.039927486,-0.046164937,0.0011801299,0.008131356,0.06171399,0.062941216,0.015005858,-0.103732534,-0.08662015,-0.06788121,-0.028836424,-0.001562136,0.050091196,-0.015815953,-0.039836664,0.013529718,0.023907416,-0.01549037,0.1605826,-0.030886173,0.00841369,-0.014370387,0.026236176,0.06257649,0.10479247,-0.03628514,-0.081199065,-0.110691965,-0.07589982,-0.003115336,-0.0648983,0.07300865,-0.03513872,-0.009218595,0.042570006,0.0074040033,-0.024664266,0.0062943897,-0.057389293,0.08022398,-0.04534081,0.031465877,0.13557026,0.06832914,0.078610055,0.02525788,0.10850726,0.10252656,-0.09303516,0.025837854,-0.00808202,-0.0175572,0.007170376,-0.008954623,-0.037027992,-0.045662183,-0.02351984,0.024727657,-0.016372884,-0.0142566655,-0.09442157,0.04630112,-0.034304302,-0.07306289,0.019616093,-0.0750716,0.0024076207,0.078918405,0.05467998,-0.0027565039,-1.8126642e-08,-0.08050925,0.010130529,0.049432673,-0.020129232,0.0071261222,0.025264323,0.036105826,-0.05996495,0.0040671197,-0.052028347,0.0017699895,0.0790233,0.16072726,0.04275628,0.053195626,-0.044865057,0.05511907,0.11720408,-0.062657915,-0.06661379,-0.09723387,-0.06789632,-0.051061172,0.026112782,0.026207205,0.021803517,0.035006654,0.006111371,0.084354594,-0.029238822,0.026229862,-0.043917373,-0.003059834,-0.028853405,-0.10537471,-0.030031051,-0.023757808,0.00016009774,-0.03562493,-0.03339227,-0.011417447,-0.006316148,-0.013844411,0.038314328,-0.045274302,0.0023489755,-0.004488566,-0.06112775,-0.048164006,0.07229555,0.021424996,0.0033747712,0.025545679,0.0072756642,0.014615922,0.075033605,0.008413371,0.009344983,0.09265562,-0.03857441,0.07211084,-0.02583843,0.07285315,-0.04682338 +1.14.11.12,Requires Fe2+.,384,1.0,0.0017429227,-0.0120922215,-0.038558863,0.09142432,0.06785902,-0.058863577,-0.01458679,-0.014261219,-0.07332533,-0.05796829,-0.011215821,-0.015509965,-0.07202684,0.04249708,0.024249421,-0.03321543,0.019945407,-0.020375494,0.030671543,0.04413522,0.05039896,-0.076645784,0.061869685,-0.0806471,-0.07299566,0.021112347,0.025108593,0.011541391,0.031364482,-0.07522699,-0.013137532,0.024824042,0.00782358,-0.025159573,-0.07306664,0.037389968,0.028623296,-0.041204736,-0.07766069,-0.044195645,-0.092444964,-0.051226787,0.004661776,0.019761538,0.016014727,-0.08959922,0.10965217,-0.073083736,0.07675235,0.025391651,-0.047817487,0.012119977,-0.019110482,0.06658772,0.051607575,-0.03403417,0.020699611,-0.032469366,0.0004800927,-0.011221626,-0.017793885,-0.06576893,-0.036475454,0.05335543,0.06464099,0.022822551,0.047862507,-0.07560602,-0.05039111,0.036225423,-0.025612224,0.03532552,-0.052344717,-0.028691012,-0.016723612,0.03522456,0.07033103,-0.055389967,0.12350712,0.0123082185,-0.123151205,-0.03510367,-0.03319499,0.027769485,0.08925549,0.071048334,-0.042034563,-0.054983024,-0.099674575,0.055655226,0.028191065,0.060977615,0.023211394,0.05470533,0.03721542,-0.0003429361,0.0072218375,-0.019805033,-0.08760099,0.06914633,-0.09391643,0.05948289,-0.02463003,0.067270935,-0.015539489,-0.028376048,-0.031077085,0.06590933,-0.0741654,0.0145040555,0.07959369,-0.0071991794,0.03405784,-0.004239101,0.03415664,0.02927697,-0.0066822385,-0.003935083,0.025430325,0.02711847,0.076907285,0.034331284,-0.06844991,0.025891433,-0.060349308,-0.089497626,-0.018967083,-2.074728e-33,0.03875058,0.09118988,-0.0090543805,0.06307697,-0.019233564,0.035965927,-0.06977131,-0.034298696,-0.03491918,0.013025775,-0.051146638,-0.037127115,0.012320491,-0.006813886,0.08286553,-0.12027711,0.062278084,-0.0055497363,0.08970242,-0.0406022,0.06444415,0.01447369,0.01988652,-0.07293302,0.043469448,0.12426544,0.011997116,-0.021612443,0.012783716,0.044091817,0.034164663,-0.05379804,-0.05068308,0.012276918,0.032229804,0.026016157,-0.051090825,-0.02843097,-0.012233348,-0.02187568,-0.010255581,0.07091546,-0.048615243,-0.031659544,0.042125147,-0.101625815,0.0625771,0.08382098,0.008944647,0.108518094,-0.041440237,0.015257649,-0.0135497,0.03280594,-0.008964016,0.0077318638,0.04506646,0.0095773125,0.060724284,0.096419096,0.007831181,0.0152376685,0.09397592,0.07084752,0.008463016,0.0075988555,-0.037691083,0.06428395,-0.022946876,0.04885402,-0.04825891,0.054102004,0.101672865,0.012057786,0.039643303,-0.04500026,-0.039373722,-0.10287057,0.05524383,0.014613132,-0.080241226,-0.04578716,-0.008564254,0.006317822,-0.01804736,-0.030574838,-0.055968333,-0.005918972,0.03520392,-0.021981578,0.021104828,-0.063459106,0.028721329,-0.046397213,-0.032900482,1.9423185e-33,-0.050131872,-0.07233176,0.006517437,-0.009770115,0.0012152584,0.03262746,-0.026354922,-0.17247894,-0.019856434,0.081106424,0.02197408,0.05406422,0.04717696,-0.04765909,0.060986374,0.03714663,-0.064488016,-0.05029234,0.0886715,-0.009229691,0.0075599453,0.08849569,0.027635824,0.04191214,0.039998353,0.05784655,-0.032710597,0.009904373,0.018160459,0.054377098,0.05682356,0.02135305,-0.09520718,-0.037526492,-0.050535947,-0.08163383,0.08369463,0.043726932,0.0040038014,-0.003337331,0.037788805,0.036244527,-0.0042140274,0.14379315,-0.04684554,0.013663093,0.07926568,-0.020665063,0.030223744,0.05057593,-0.018513858,-0.086178035,-0.07583318,-0.03216732,-0.025714448,-0.06935636,0.028185032,0.059341352,-0.026195612,0.029161802,0.062405966,-0.021127302,0.07086086,-0.05336216,0.03923583,-0.052638926,-0.013585774,0.13479158,0.02843234,0.049202528,0.04161349,0.09417971,0.10558358,-0.06084688,-0.021666436,0.0059049153,-0.015171688,0.037239682,0.025117068,-0.019119684,-0.02553583,0.00070164853,0.0087346425,-0.04532933,0.030254306,-0.12709531,0.025486352,0.0056386716,-0.031363763,-0.0065417024,-0.044666093,0.03406188,0.051363,0.020588111,-0.08177112,-1.4773268e-08,-0.07523463,0.0011237485,0.016023146,-0.042561483,0.008760203,0.0085942,0.04015263,-0.031745512,-0.028120264,0.0130028855,0.03657854,0.03740095,0.09984513,-0.0011536697,0.05729272,-0.034588095,0.019776205,0.089067765,-0.07187036,-0.05924737,-0.080893286,-0.041323666,-0.033375647,0.0396294,0.011878222,-0.019456035,-0.0046423576,-0.029919215,0.07149047,0.021430269,-0.058517,0.0038932343,-0.027600368,-0.023435276,-0.02749246,0.027492367,0.0054548956,0.009215663,-0.013423877,-0.050297283,-0.012353761,0.062447686,-0.02013099,-0.022789508,-0.031834174,0.0075663156,-0.07518661,-0.059446964,-0.055041708,-0.0062214406,0.053594608,-0.006450981,0.023155697,-0.008346988,0.014302364,0.09564623,-0.009267767,0.011880439,0.09211617,-0.026712509,0.060796443,-0.03838758,0.041849215,-0.062430806 +1.14.11.13,Also acts on a number of other gibberellins.,384,1.0,-0.013429938,-0.09011565,0.036310904,0.030785332,-0.037287667,-0.033554837,0.09062443,-0.052044936,0.011395264,0.006333277,0.05884343,0.0103833405,-0.07125129,0.09218978,-0.022306427,-0.013672073,-0.0343573,0.06047253,0.032154437,0.010683468,0.000980683,-0.010701764,0.10512682,0.02135053,-0.008909549,-0.071757495,-0.044964857,0.028840581,0.015408387,-0.06542894,-0.026540222,0.044346195,0.028935578,0.02763018,-0.030572291,0.13834257,0.03339687,0.070989095,0.091058485,0.026100896,0.060983945,-0.04570815,0.04726137,0.032874268,-0.035565343,0.0007351824,-0.059065863,0.040415507,0.026074724,0.009592276,-0.027979774,-0.07879665,0.003335755,0.095094785,0.022698307,-0.017314216,-0.04662995,-0.041454565,0.063560255,-0.04499895,-0.06630414,0.030790301,-0.011769238,-0.03483784,-0.05154648,0.018295739,-0.063371934,0.0362321,-0.049828142,0.041163933,0.14739339,-0.023401853,-0.043580778,-0.009511373,-0.044555362,0.018466873,-0.060160566,0.012146989,-0.052923974,-0.07553417,0.0032986875,0.024742203,0.027283935,0.01189798,0.021549731,-0.026032,-0.009336586,0.00814309,-0.034140915,0.1009456,0.020455437,0.008086162,0.059172016,0.0318784,-0.0024736116,-0.06657668,0.03064364,0.068759136,-0.055901665,0.023740657,-0.004902311,-0.073820114,0.06379602,-0.030876307,0.0026449545,-0.03459054,-0.0028683487,-0.03053848,-0.019456979,-0.050690155,-0.09851487,-0.05605585,-0.046488702,0.05875814,0.00088107045,0.07585744,-0.0375333,0.05127707,-0.08866565,-0.004602575,0.06405222,0.032962374,-0.04907609,0.060561668,-0.011057055,0.049361557,-0.11199115,-8.905014e-34,0.05992386,0.025752844,-0.09417158,0.034310117,-0.041079737,0.036080506,-0.08500076,-0.055086073,-0.0052241567,-0.006254608,-0.11727057,-0.019793484,0.009992423,0.049415216,0.017117506,0.04912962,-0.049750224,0.021558104,0.021738846,0.008166969,0.04727624,0.08239706,-0.08415973,-0.033915862,-0.018809361,0.06325932,0.0048940172,-0.069907494,-0.014911706,0.021147933,0.08988707,-0.010871412,-0.022821281,0.062515214,0.0726178,0.039837126,-0.012001198,-0.07324513,-0.07198776,0.04485489,-0.04013417,-0.036189474,-0.06802548,-0.005861998,0.07751576,-0.07151058,-0.0073961504,0.021538021,0.027831094,0.027800178,0.069221504,0.035015997,0.065536834,0.02039314,0.042122975,0.011535881,0.02965934,0.025595535,0.021440452,0.029589383,0.05174446,-0.010279267,-0.02619482,-0.101146154,0.04843596,0.02525025,-0.07571387,-0.0010514723,-0.036467604,0.020292241,-0.007996603,-0.033479232,-0.037783783,-0.0013493126,-0.07927399,-0.012661964,0.026105976,-0.033485446,-0.029232515,0.042565115,-0.08166933,-0.04052702,-0.0074477764,-0.07623482,-0.05102829,0.06781661,0.092155434,-0.07373077,-0.047453206,0.017133275,0.041445263,0.014930704,-0.04741,-0.037661772,-0.07826628,2.8219788e-34,-0.057616133,0.0028420761,0.01397736,0.09533464,-0.07364102,0.0065556173,-0.011051617,-0.03137886,0.049923997,0.046508737,-0.083606645,0.0036410901,0.049337454,0.017303692,0.07355387,0.049037546,0.035184305,0.055778,-0.0139115965,-0.04516702,-0.07831994,0.07277102,-0.0016557521,0.03639581,-0.068899915,0.057948094,-0.017240042,0.0020665133,-0.045505855,-0.026262011,-0.029942807,-0.03171943,-0.06880426,-0.051160224,0.0335496,0.083749615,0.01736234,0.049749047,-0.02557124,-0.022299506,0.06311468,-0.028656298,0.069942705,0.06439211,0.011074175,0.02821793,0.06949198,0.10289771,-0.15090036,0.044991318,-0.03683591,0.02099926,-0.00808079,-0.003862407,0.035985976,-0.025312964,-0.018471284,-0.044100802,-0.02731614,-0.09419346,0.027559228,-0.036529962,-0.019315619,0.014898983,0.061787333,0.016894383,-0.13521023,0.031976152,0.045810737,0.0129482625,0.08791671,-0.057878505,-0.08805276,-0.06565197,-0.01986953,0.06548351,-0.074467346,-0.06945775,0.025341246,-0.07420205,-0.036926262,-0.05556067,0.038645282,0.017129287,-0.010015621,0.026206257,-0.0026215774,0.017603863,0.052574363,0.030731559,0.010360858,-0.009029168,0.06856473,0.02375169,0.0054984847,-1.9188311e-08,0.007238201,0.08350628,0.007051855,-0.003578359,0.055437747,-0.026747517,0.008994745,0.03898591,0.003161673,0.07164538,-0.017341707,0.01701161,0.08104695,-0.035105716,0.1522259,-0.043535393,0.017629042,0.0030306934,-0.086628795,0.03622554,-0.06119376,0.0028915678,-0.024960741,0.04973335,-0.13761862,-0.06622901,0.038884956,0.0037921325,-0.01780742,0.02602534,0.04455418,-0.004387692,-0.07845229,-0.07904957,0.031915937,0.08509786,-0.08807371,-0.0355614,0.07081285,0.0040868237,-0.031157002,-0.07011238,0.0005652296,0.08872253,-0.022957293,-0.01933521,0.0036823938,-0.12570956,0.03548035,0.04818349,0.0471967,0.05098645,0.03805115,0.05714426,-0.034474213,0.014424893,0.04121336,0.0008640218,0.04877291,-0.01043252,-0.041120205,0.00029880527,0.09483414,-0.0058170063 +1.14.11.14,Requires Fe2+ and ascorbate.,384,1.0,0.004124434,-0.051354267,-0.060412705,0.09901642,-0.011559343,-0.019695476,0.009181307,0.013098153,-0.049380504,-0.037341837,0.03959026,-0.0055141808,-0.08832038,0.059819613,0.042381227,-0.039317414,0.098113924,-0.0325441,0.015588932,0.051180568,0.123099945,-0.028480688,0.08289687,-0.05802108,-0.07791917,-0.014590836,-0.04010224,-0.024484629,0.034198742,-0.08973618,9.3954106e-05,0.0048319628,-0.007135337,-0.06491593,-0.07164672,0.0041014636,-0.020468865,-0.0048646093,-0.03402048,-0.014489571,0.023970854,-0.074299574,-0.02160852,0.023310533,0.016668228,-0.039474797,0.090037085,-0.04664531,0.060221747,0.05835281,-0.05206555,-0.02244425,0.024491256,0.071849935,-0.030625233,-0.021087443,-0.040811565,-0.054319482,-0.016097303,0.023016851,-0.07018526,0.009026886,-0.039565776,0.028430779,0.014954204,0.0010352334,0.010944532,-0.032164503,-0.018683458,0.048419975,-0.042469017,0.0014899017,-0.020810528,0.05150577,-0.0026296722,-0.00884715,0.0505166,-0.056830365,0.067691326,0.022053778,-0.10321405,-0.0538491,0.004538305,0.05587948,0.046709508,0.08306765,-0.024001647,-0.0384922,-0.1337014,0.088401444,-0.02572032,0.040524453,-0.022029905,0.019421227,-0.010993662,-0.02727087,0.018769413,-0.015915742,-0.077441275,0.04130723,-0.08133127,0.0718422,-0.054680616,0.056784797,-0.009606944,-0.06435656,-0.07635962,0.00744762,0.003978297,-0.011408741,0.015102946,-0.0057537006,0.018099647,-0.0061748745,0.03272898,0.069261916,0.0058845216,-0.0025713267,0.014989733,-0.004228114,0.05205622,-0.0026679407,-0.055393063,0.038267307,-0.04996847,-0.09770224,0.032118384,-7.1639475e-34,0.05841243,0.10381546,0.044895284,0.0624173,-0.058408987,0.084315814,-0.0484664,-0.03332188,0.02412716,-0.02661737,0.0033307474,-0.062410492,0.017200667,0.033913728,0.048683126,-0.14971116,0.021229649,-0.026431022,0.080655135,-0.04873955,0.059519533,0.035531264,-0.0020676528,-0.0074908165,-0.05770358,0.08081117,-0.028241668,0.009227095,0.018702412,0.039029438,0.020965923,-0.019656487,-0.037403725,-0.055228565,0.027502047,0.039120946,-0.044212554,-0.047428537,-0.021039028,-0.010531438,-0.024407499,0.03544007,-0.09694866,-0.024670115,-0.018324574,-0.07179034,0.036607143,0.06970383,0.030849837,0.07003276,-0.0053930925,0.052110903,0.07791187,0.005462096,-0.012642633,0.02275819,-0.010304155,-0.048324008,0.02519482,0.063924804,0.0626058,0.009885993,0.012501716,0.0510577,-0.068664655,0.04343895,-0.012236792,0.016121069,-0.012297096,-0.0021210157,-0.06938487,0.07362139,0.06461386,-0.006003747,-0.011510255,-0.0029026987,-0.05858666,-0.07215756,0.058810737,-0.017007004,0.0034846575,-0.06354861,-0.0253717,0.021897424,0.022731839,-0.017746337,-0.021823423,0.008806094,0.05394825,-0.047474727,0.0137573425,-0.043390773,0.029154362,-0.082994014,0.054455735,-2.4161155e-34,-0.014195737,-0.0718742,-0.010806257,0.06985909,0.03920389,0.05977598,0.040455677,-0.112389594,-0.06295592,0.04418154,-0.0004156027,0.02244394,0.016045269,-0.038251106,0.050148003,0.013290346,-0.0661799,0.04687132,0.0648844,0.027702792,-0.0029073327,0.1237578,0.04144074,0.09312009,0.0028234294,0.039927486,-0.046164937,0.0011801299,0.008131356,0.06171399,0.062941216,0.015005858,-0.103732534,-0.08662015,-0.06788121,-0.028836424,-0.001562136,0.050091196,-0.015815953,-0.039836664,0.013529718,0.023907416,-0.01549037,0.1605826,-0.030886173,0.00841369,-0.014370387,0.026236176,0.06257649,0.10479247,-0.03628514,-0.081199065,-0.110691965,-0.07589982,-0.003115336,-0.0648983,0.07300865,-0.03513872,-0.009218595,0.042570006,0.0074040033,-0.024664266,0.0062943897,-0.057389293,0.08022398,-0.04534081,0.031465877,0.13557026,0.06832914,0.078610055,0.02525788,0.10850726,0.10252656,-0.09303516,0.025837854,-0.00808202,-0.0175572,0.007170376,-0.008954623,-0.037027992,-0.045662183,-0.02351984,0.024727657,-0.016372884,-0.0142566655,-0.09442157,0.04630112,-0.034304302,-0.07306289,0.019616093,-0.0750716,0.0024076207,0.078918405,0.05467998,-0.0027565039,-1.8126642e-08,-0.08050925,0.010130529,0.049432673,-0.020129232,0.0071261222,0.025264323,0.036105826,-0.05996495,0.0040671197,-0.052028347,0.0017699895,0.0790233,0.16072726,0.04275628,0.053195626,-0.044865057,0.05511907,0.11720408,-0.062657915,-0.06661379,-0.09723387,-0.06789632,-0.051061172,0.026112782,0.026207205,0.021803517,0.035006654,0.006111371,0.084354594,-0.029238822,0.026229862,-0.043917373,-0.003059834,-0.028853405,-0.10537471,-0.030031051,-0.023757808,0.00016009774,-0.03562493,-0.03339227,-0.011417447,-0.006316148,-0.013844411,0.038314328,-0.045274302,0.0023489755,-0.004488566,-0.06112775,-0.048164006,0.07229555,0.021424996,0.0033747712,0.025545679,0.0072756642,0.014615922,0.075033605,0.008413371,0.009344983,0.09265562,-0.03857441,0.07211084,-0.02583843,0.07285315,-0.04682338 +1.14.11.15,Requires Fe2+ and ascorbate.,384,1.0,0.004124434,-0.051354267,-0.060412705,0.09901642,-0.011559343,-0.019695476,0.009181307,0.013098153,-0.049380504,-0.037341837,0.03959026,-0.0055141808,-0.08832038,0.059819613,0.042381227,-0.039317414,0.098113924,-0.0325441,0.015588932,0.051180568,0.123099945,-0.028480688,0.08289687,-0.05802108,-0.07791917,-0.014590836,-0.04010224,-0.024484629,0.034198742,-0.08973618,9.3954106e-05,0.0048319628,-0.007135337,-0.06491593,-0.07164672,0.0041014636,-0.020468865,-0.0048646093,-0.03402048,-0.014489571,0.023970854,-0.074299574,-0.02160852,0.023310533,0.016668228,-0.039474797,0.090037085,-0.04664531,0.060221747,0.05835281,-0.05206555,-0.02244425,0.024491256,0.071849935,-0.030625233,-0.021087443,-0.040811565,-0.054319482,-0.016097303,0.023016851,-0.07018526,0.009026886,-0.039565776,0.028430779,0.014954204,0.0010352334,0.010944532,-0.032164503,-0.018683458,0.048419975,-0.042469017,0.0014899017,-0.020810528,0.05150577,-0.0026296722,-0.00884715,0.0505166,-0.056830365,0.067691326,0.022053778,-0.10321405,-0.0538491,0.004538305,0.05587948,0.046709508,0.08306765,-0.024001647,-0.0384922,-0.1337014,0.088401444,-0.02572032,0.040524453,-0.022029905,0.019421227,-0.010993662,-0.02727087,0.018769413,-0.015915742,-0.077441275,0.04130723,-0.08133127,0.0718422,-0.054680616,0.056784797,-0.009606944,-0.06435656,-0.07635962,0.00744762,0.003978297,-0.011408741,0.015102946,-0.0057537006,0.018099647,-0.0061748745,0.03272898,0.069261916,0.0058845216,-0.0025713267,0.014989733,-0.004228114,0.05205622,-0.0026679407,-0.055393063,0.038267307,-0.04996847,-0.09770224,0.032118384,-7.1639475e-34,0.05841243,0.10381546,0.044895284,0.0624173,-0.058408987,0.084315814,-0.0484664,-0.03332188,0.02412716,-0.02661737,0.0033307474,-0.062410492,0.017200667,0.033913728,0.048683126,-0.14971116,0.021229649,-0.026431022,0.080655135,-0.04873955,0.059519533,0.035531264,-0.0020676528,-0.0074908165,-0.05770358,0.08081117,-0.028241668,0.009227095,0.018702412,0.039029438,0.020965923,-0.019656487,-0.037403725,-0.055228565,0.027502047,0.039120946,-0.044212554,-0.047428537,-0.021039028,-0.010531438,-0.024407499,0.03544007,-0.09694866,-0.024670115,-0.018324574,-0.07179034,0.036607143,0.06970383,0.030849837,0.07003276,-0.0053930925,0.052110903,0.07791187,0.005462096,-0.012642633,0.02275819,-0.010304155,-0.048324008,0.02519482,0.063924804,0.0626058,0.009885993,0.012501716,0.0510577,-0.068664655,0.04343895,-0.012236792,0.016121069,-0.012297096,-0.0021210157,-0.06938487,0.07362139,0.06461386,-0.006003747,-0.011510255,-0.0029026987,-0.05858666,-0.07215756,0.058810737,-0.017007004,0.0034846575,-0.06354861,-0.0253717,0.021897424,0.022731839,-0.017746337,-0.021823423,0.008806094,0.05394825,-0.047474727,0.0137573425,-0.043390773,0.029154362,-0.082994014,0.054455735,-2.4161155e-34,-0.014195737,-0.0718742,-0.010806257,0.06985909,0.03920389,0.05977598,0.040455677,-0.112389594,-0.06295592,0.04418154,-0.0004156027,0.02244394,0.016045269,-0.038251106,0.050148003,0.013290346,-0.0661799,0.04687132,0.0648844,0.027702792,-0.0029073327,0.1237578,0.04144074,0.09312009,0.0028234294,0.039927486,-0.046164937,0.0011801299,0.008131356,0.06171399,0.062941216,0.015005858,-0.103732534,-0.08662015,-0.06788121,-0.028836424,-0.001562136,0.050091196,-0.015815953,-0.039836664,0.013529718,0.023907416,-0.01549037,0.1605826,-0.030886173,0.00841369,-0.014370387,0.026236176,0.06257649,0.10479247,-0.03628514,-0.081199065,-0.110691965,-0.07589982,-0.003115336,-0.0648983,0.07300865,-0.03513872,-0.009218595,0.042570006,0.0074040033,-0.024664266,0.0062943897,-0.057389293,0.08022398,-0.04534081,0.031465877,0.13557026,0.06832914,0.078610055,0.02525788,0.10850726,0.10252656,-0.09303516,0.025837854,-0.00808202,-0.0175572,0.007170376,-0.008954623,-0.037027992,-0.045662183,-0.02351984,0.024727657,-0.016372884,-0.0142566655,-0.09442157,0.04630112,-0.034304302,-0.07306289,0.019616093,-0.0750716,0.0024076207,0.078918405,0.05467998,-0.0027565039,-1.8126642e-08,-0.08050925,0.010130529,0.049432673,-0.020129232,0.0071261222,0.025264323,0.036105826,-0.05996495,0.0040671197,-0.052028347,0.0017699895,0.0790233,0.16072726,0.04275628,0.053195626,-0.044865057,0.05511907,0.11720408,-0.062657915,-0.06661379,-0.09723387,-0.06789632,-0.051061172,0.026112782,0.026207205,0.021803517,0.035006654,0.006111371,0.084354594,-0.029238822,0.026229862,-0.043917373,-0.003059834,-0.028853405,-0.10537471,-0.030031051,-0.023757808,0.00016009774,-0.03562493,-0.03339227,-0.011417447,-0.006316148,-0.013844411,0.038314328,-0.045274302,0.0023489755,-0.004488566,-0.06112775,-0.048164006,0.07229555,0.021424996,0.0033747712,0.025545679,0.0072756642,0.014615922,0.075033605,0.008413371,0.009344983,0.09265562,-0.03857441,0.07211084,-0.02583843,0.07285315,-0.04682338 +1.14.11.16,"Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors.",384,0.99999994,-0.012838683,-0.081134975,-0.06436889,0.036088068,0.12636888,-0.0010362223,0.048763037,0.020694846,-0.035985135,0.023799643,0.061774205,-0.02834392,-0.04730912,0.10586436,-0.013938473,-0.013826588,-0.026906995,0.078053564,0.031072995,0.009185243,-0.05659458,-0.026166659,0.027120842,-0.022156568,-0.08435834,0.0006466677,0.042262875,-0.059563,0.042332854,-0.009696413,-0.028073732,0.01341292,0.029845523,-0.07186018,-0.09572871,0.041581098,-0.029455494,-0.050947957,-0.15091437,-0.0012958443,0.0638627,-0.11338586,0.0009790615,-0.03650204,0.041630615,-0.115333684,0.067110345,0.0049853167,0.0059085684,0.07289501,-0.0037191762,-0.026479753,-0.017365612,0.06785337,-0.029827865,0.003999616,-0.098477714,-0.051986482,-0.0068242145,0.026288899,-0.056754954,-0.069386214,0.0129339835,-0.0029751274,0.05600849,-0.036135573,0.054882452,-0.019921578,-0.053575646,-0.0038922904,0.03878286,-0.029059285,-0.030912297,0.020076487,0.036468398,0.070445284,-0.016067963,-0.012130529,0.06141436,0.05196843,-0.034316108,0.046683982,0.01877601,0.1161616,-0.023831774,0.08486878,-0.08315064,-0.0062412135,-0.12508354,0.08518134,0.07602394,0.023732036,0.07743634,0.021300063,0.035485614,0.04628653,0.032027744,-0.03312297,0.010331993,-0.0016338851,-0.15492566,0.024180606,-0.031625338,0.078580126,-0.019394558,-0.09742697,-0.0986141,0.048725203,-0.04178705,0.055429094,0.054787155,-0.042248122,0.043057118,0.010869569,0.091844566,0.013355955,0.06767265,-0.048694775,0.010494203,-0.05672034,0.029985817,0.07353844,-0.021300092,0.039186697,0.0016562972,0.0062005823,0.0054071867,2.9060672e-33,0.012052652,0.08642458,0.07954244,0.01220091,-0.07225754,0.0021012176,-0.059297804,-0.022371195,0.021131411,-0.014299566,-0.040174782,0.008359292,0.052695017,0.10507395,-0.012490664,-0.053440243,0.048977554,-0.033574626,0.073575266,0.0013797878,0.050605718,-0.013908802,0.0105204545,0.014721891,-0.03464567,0.046645172,-0.062155403,0.09061236,0.0033078024,-0.009652161,-0.038680553,-0.024481902,-0.007233622,-0.019242741,0.0652468,-0.048334766,0.0015336757,-0.047891613,-0.03581427,0.03922857,0.04645266,0.03379241,-0.06861083,0.0011827264,0.062217996,-0.058030624,0.028696463,0.015094817,-0.08121672,0.04232908,0.025233986,0.06176157,0.029033128,-0.06059732,-0.016307011,0.018548328,-0.03212977,0.0041989,-0.038018458,-0.0010648309,-0.08350542,-0.047716413,0.005528683,0.11184286,-0.03586526,-0.013030269,-0.06477329,-0.06869345,-0.045304753,0.01713962,0.00056441984,0.07120244,0.05910494,0.004537087,0.055639274,-0.07947943,-0.101085395,0.06675867,0.050346695,0.034286816,-0.026775768,0.025235686,-0.033959143,0.04211538,-0.006100143,-0.053735,0.030712958,-0.017209666,0.06317563,-0.086252525,-0.007486763,-0.0024696686,0.0059657935,0.01797271,0.040209394,-4.783632e-33,0.044489454,-0.10847324,0.06303541,-0.035247028,0.010957725,0.08896546,0.020766592,-0.050845247,0.09433704,-0.010830823,0.07769056,0.02708418,-0.04649503,-0.026210021,0.005171512,0.0720975,-0.09832423,0.092055425,-0.023371683,-0.06308938,-0.058268454,-0.0036770147,0.030547962,-0.01825368,0.05963715,0.0037803522,-0.103799336,0.020017786,-0.010652498,0.09199615,-0.037006658,-0.030099047,-0.06804329,-0.078271426,0.013610171,-0.00685179,-0.04646454,0.04997272,-0.01602198,-0.015143339,-0.031526446,-0.0062583387,0.035943296,0.02108664,0.021232693,-0.0027424216,0.056048464,0.06274016,0.049563766,-0.008196605,-0.01250761,0.014280749,-0.06072495,0.017039107,0.001961232,0.027237097,0.08883295,0.062177602,0.036328986,-0.021185184,-0.037816178,-0.10341107,0.0665793,-0.037049487,0.036787022,-0.02377398,0.04360074,0.059328303,0.029556986,-0.013118826,0.04802031,-0.019412946,0.11732806,-0.04572166,-0.009396675,-0.044902124,-0.06489255,0.007119027,-0.027299946,0.028898064,-0.06706962,-0.019610768,-0.048026204,0.0052192993,-0.01179177,-0.017439932,0.03638243,-0.028760199,-0.04332513,-0.0103936605,-0.072788484,-0.059046704,-0.060273454,0.052714076,-0.018937362,-3.3630176e-08,0.020733248,-0.061991658,-0.080792725,-0.098767206,0.035986207,0.034990776,-0.07260661,-0.059602447,0.026844937,0.04840697,0.043401774,0.093041874,0.07566666,0.05995413,0.057025775,-0.06373222,0.046735983,0.06654609,-0.057954796,-0.104876354,-0.06521053,-0.020158485,-0.002055201,-0.0028748645,-0.02672548,-0.092943385,-0.011117005,-0.0037892575,-0.028706124,0.026248092,0.043702304,-0.030308861,-0.013267904,0.022141289,0.0036851878,0.033548962,0.018416185,-0.053734623,-0.0195514,0.055444807,0.0015790286,-0.01575939,-0.040958438,-0.0037462,0.00034334205,0.00882891,0.012473779,0.016486172,-0.058495574,0.012836101,-0.002532211,-0.028603774,-0.053273544,-0.080719166,0.00081905385,0.06929696,0.03114894,-0.037785117,0.08214369,-0.0543159,-0.02696326,-0.0059098178,0.13774669,-0.03754209 +1.14.11.17,"Requires FeII. The enzyme from Escherichia coli also acts on pentanesulfonate, 3-(N-morpholino)propanesulfonate and 2-(1,3-dioxoisoindolin-2-yl)ethanesulfonate, but at lower rates.",384,1.0,-0.034814287,-0.08593242,-0.07403406,-0.02101053,0.018867362,-0.014075214,-0.056650896,0.031125307,0.07461038,-0.05392042,0.010880936,-0.00654364,-0.10415537,0.1350991,0.015442902,0.017913671,-0.022022078,0.051871102,-0.0331973,-0.04706577,0.0933661,0.014808074,-0.004128611,-0.022145456,-0.09065561,-0.0036642689,0.041453958,0.039391384,-0.03842573,-0.07480696,-0.0056213536,-0.013015785,-0.00748569,-0.10611937,0.02793228,0.085460916,-0.026340075,-0.051343083,0.111730754,-0.018136378,-0.013054853,0.0038502463,0.013460524,-0.03149106,0.057558484,-0.078553684,-0.00055416033,0.035108205,0.08451085,-0.0404841,-0.127726,-0.0018907327,-0.029111054,0.099875405,0.058438838,-0.03121047,-0.0028914781,-0.05763289,-0.005734741,-0.019294636,-0.0048244246,0.014795953,0.050957523,-0.0113945585,-0.035027213,-0.04000007,0.032040033,-0.05102311,0.053210404,-0.04249496,-0.027949175,-0.00847931,0.02134163,0.034319106,0.014813257,0.067780964,-0.029657621,-0.04241627,0.10274364,-0.028897006,0.0030282214,-0.07187397,0.019047568,0.11041498,0.026943356,-0.023633016,-0.0063755214,0.001176201,0.06090316,0.12102264,-0.0013460999,0.011077765,-0.04077844,-0.038514253,-0.03078546,-0.027580822,-0.0349981,0.03072251,-0.062143777,0.0097715445,-0.023198687,0.016912816,-0.07111673,0.0013634533,-0.050778538,-0.002581021,0.053568017,0.0591589,-0.038917135,0.012917948,-0.005761301,-0.010172267,0.07727415,-0.05087869,-0.07716674,0.042906057,0.033777952,-0.11223996,-0.048162866,0.008463492,0.022751767,-0.004027729,-0.033134557,0.06627731,-0.05689559,0.058464378,-0.069723584,3.3584138e-33,0.09269195,0.08924315,0.031590287,0.021025857,-0.0070526223,-0.036314107,-0.087101735,-0.012021685,-0.056552626,-0.102659516,-0.030384129,-0.04380117,0.0070287306,0.0027824626,0.0028418528,-0.029223299,0.02772124,0.017021228,0.034852725,-0.02776941,0.08377721,7.313488e-05,0.014914183,-0.07220301,0.043585196,0.019801697,-0.0018376107,0.040950097,-0.0057724505,0.0032700796,0.0639417,-0.0982427,-0.06975513,-0.0010675837,0.1039393,-0.0109972805,-0.019686138,-0.04490551,-0.038283285,0.043076403,-0.0026053844,0.09920615,0.0076792752,0.0033024603,0.071822725,-0.050229885,-0.09457564,0.1273389,0.05738873,0.115097776,0.042118136,-0.056460056,0.04421179,-0.04330247,-0.003157389,-0.012490737,-0.0032188105,-0.056928493,0.06805085,0.011294679,-0.04054795,0.026799966,-0.090063676,0.017355805,0.011089732,0.04033871,-0.0066447626,-0.0036428205,-0.0080614025,0.07335438,-0.079075456,0.0003460672,-0.05380591,0.033222023,0.0005279499,-0.039196093,-0.04422379,-0.06732447,0.060674757,0.014292674,0.026045537,-0.095777966,-0.033215124,0.033064537,-0.09931442,0.0017859512,-0.04840297,0.032322444,0.023820573,0.030329319,0.052431066,-0.07803257,-0.019479379,0.037760776,0.021317907,-4.0431374e-33,0.02869321,-0.067484826,0.06158503,-0.07304569,-0.10143839,0.061346643,-0.026659077,-0.055833474,0.092674404,-0.03112335,-0.016670194,-0.0077703004,0.07053446,-0.036945187,-0.045730963,0.038928952,-0.009080953,-0.02053605,0.04352614,0.0070914836,-0.0025428676,0.0870522,-0.02138582,0.10167996,0.0243913,0.060340606,-0.0009075204,0.046028584,-0.004308016,0.030939154,0.009406343,-0.037495013,-0.003902396,-0.05920682,-0.033701617,0.07235535,-0.017262451,0.0009268877,0.035536166,-0.008340002,0.019943865,-0.007663268,-0.0043833912,0.12200208,-0.04187467,0.046951815,-0.06620809,0.012154816,0.05278821,-0.013591622,-0.025480788,-0.060773242,-0.044428088,-0.038488425,0.026436685,-0.030551745,0.010497881,-0.036227353,-0.033925008,0.0009731547,0.028964048,-0.04323222,0.003512445,-0.076340325,-0.0147747295,0.0900441,-0.022208484,0.027973512,0.0711894,-0.021147892,0.085219085,0.038593896,0.054665416,-0.021548739,-0.02447926,-0.0029772525,-0.05756841,0.022906106,0.026219428,0.055763643,0.060091395,0.05002037,-0.007860431,-0.090112604,0.018117186,-0.07238046,0.013409727,0.045127854,-0.00782567,0.030219292,0.022172153,0.018156067,0.03927583,0.010622999,0.015916245,-4.1000884e-08,0.009601684,-0.011232387,0.057887875,-0.023224529,-0.08171785,0.01664897,0.083928,-0.04035541,0.04110591,-0.02587398,0.023164654,0.14696032,0.04534451,0.0074217473,0.0706683,-0.004050129,-0.03989851,-0.0012042884,-0.033331603,-0.04583042,-0.06200539,-0.0072331107,-0.112765215,-0.028644389,0.037814356,-0.07674456,0.031657312,-0.06705955,0.0034019875,0.035922203,0.009163909,-0.0059968713,-0.018040655,-0.0473687,-0.09609587,0.03252131,-0.047829427,-0.03883789,-0.045901958,0.0063659702,0.06846307,0.06457708,-0.10171979,-0.026853444,-0.0017223838,-0.0009811687,-0.015078602,0.043451976,-0.047148287,-0.018977279,0.105983004,-0.06819013,0.021273362,0.01660743,-0.12262076,0.022336148,0.026012871,-0.03493516,0.008673609,-0.05267966,0.08479382,-0.04712833,0.17896482,-0.0030376175 +1.14.11.18,Part of the peroxisomal phytanic acid alpha-oxidation pathway. Requires Fe2+ and ascorbate.,384,0.99999994,-0.024620716,-0.061580617,-0.110858805,0.15684457,0.12206281,0.028689362,-0.0115670925,-0.0075545833,0.024098277,-0.06603712,0.026463725,0.027869677,-0.10791777,-0.025578486,-0.05405665,0.029736634,-0.070739694,0.052488636,-0.011372668,0.030783243,-0.002366518,0.003812219,0.06772849,-0.027037943,-0.0026504167,0.0572885,-0.0011833714,0.0033246798,0.017636178,-0.08858324,-0.007391653,-0.03814447,0.115690015,0.005258554,-0.06533337,0.05766703,-0.06680434,-0.10241369,0.0024650977,-0.010021866,-0.03425669,-0.010972764,-0.047891222,0.020472296,-0.02674151,-0.044239294,0.053259607,-0.05941783,0.06278944,0.02842661,-0.045845523,0.02005416,-0.0637589,-0.022644507,-0.06893957,0.086564876,0.019410798,-0.021705939,0.019770987,0.070519395,-0.011937818,-0.063958995,-0.029133037,0.007285264,-0.032409832,0.0050172936,0.015659735,-0.042814977,-0.0008828504,-0.10160322,0.010806816,0.017847339,0.0041148085,-0.03242132,-0.0313263,0.10093592,0.028097123,-0.05096845,0.0147821605,0.009418472,-0.0037160339,0.031619083,-0.016764324,0.05818907,0.01838121,0.037429743,-0.06122881,-0.054753702,-0.055760387,0.12530474,0.02291974,0.07843511,-0.0020116665,0.014595206,0.035490807,0.04959065,0.14780092,0.03751225,-0.029020512,-0.035451975,-0.05230643,0.0869342,-0.03427296,-0.0039881733,0.035878576,-0.026661487,-0.07800024,-0.0031104046,0.021862471,0.013406764,0.04774822,0.007137617,-0.0042809774,-0.04465187,0.069342986,0.034704134,0.047157127,-0.0003394186,0.0011872392,0.019112283,0.01508907,-0.0024386046,-0.03617907,0.035051573,-0.088997975,-0.08997473,-0.0026101747,1.5083999e-33,0.05206704,0.103169024,-0.035693165,0.029514683,-0.063395865,0.048145145,-0.097876094,-0.04474594,0.103584416,-0.015423254,-0.07721944,-0.029987684,0.037363317,-0.05602249,-0.056733225,-0.096830234,-0.010418192,-0.0631099,0.09516187,-0.0033402843,0.0429104,0.023289207,-0.025451194,-0.022142984,-0.063899375,0.0077817617,-0.04543666,0.021550836,-0.0044801054,-0.020964907,0.057425853,-0.027913526,-0.08938025,-0.058609154,0.05522299,-0.03300079,-0.007907854,-0.02084956,-0.0855531,0.05535708,-0.05503962,0.05889558,-0.044076025,0.0024502354,0.07207474,-0.07023962,-0.045756623,0.18494022,0.042747315,0.072203696,-0.04971937,0.024357527,0.08198239,0.017087374,-0.024962042,-0.05838995,-0.0339703,-0.053118616,-0.01849944,0.114460036,0.097876534,0.035405923,-0.021976149,0.09536881,-0.015826695,0.016242597,-0.093450315,0.07141556,0.049195174,0.038450595,0.00053529703,-0.015625026,0.076998584,-0.0021263934,-0.038114723,-0.014376688,-0.08980674,0.013101124,0.03506365,0.003359532,-0.06609296,0.011480932,-0.0045132027,-0.0006357277,-0.017338289,0.09416326,-0.026167177,-0.0057726935,0.017452858,-0.04877684,0.05276909,-0.02718241,-0.007119909,-0.02190661,0.07281818,-2.536075e-33,0.084030464,-0.09241426,0.001766074,-0.04750822,-0.011287554,0.0085461885,0.028351372,-0.02146113,-0.01594514,0.056380708,0.014429769,0.026133604,0.0047073243,-0.09702168,0.051918525,0.04105647,-0.014208819,0.11827815,-0.031535137,0.058057886,-0.037447944,0.07138999,-0.032340847,0.06550645,0.08208463,-0.006231477,-0.018569054,-0.047686882,-0.0030166265,0.08672737,0.05248213,0.011204458,-0.03559343,-0.034963846,0.018478954,-0.0097516235,-0.06951277,0.0019665614,0.008151879,0.0043927375,0.026413504,0.018644014,-0.028025704,0.096107386,0.023908094,0.035134695,-0.10640654,0.05156543,-0.022888536,0.01564844,-0.0054374393,-0.003904573,-0.096336596,0.008913935,0.024892623,-0.0100525385,0.02835714,-0.0017351183,0.037969567,0.023619747,-0.010691948,-0.050062396,0.038916346,-0.050772827,0.015970623,-0.014086912,0.05483528,0.1198305,0.040751748,0.0042422083,0.026641967,0.03135064,0.049057927,-0.010279762,-0.058320507,-0.010900486,-1.5837752e-05,0.008573604,-0.0189833,0.023362363,-0.026009852,0.02086433,-0.002086895,-0.06128784,0.0006088548,-0.073838666,-0.0051838127,0.05442865,-0.035774022,-0.015445339,-0.028089603,-0.040885694,-0.03228444,0.01790282,0.055161245,-2.4529934e-08,-0.07386431,0.007701642,0.05975648,0.0040110964,0.048195146,0.04272105,0.017601859,0.017473487,-0.020758979,-0.043701164,-0.014265739,0.120964706,0.038628127,-0.0025808131,0.0024167805,0.01851257,0.013904677,0.077313885,0.02908229,0.030831106,-0.10068252,-0.052423075,-0.07139367,-0.0037265264,-0.013099748,-0.11184211,-0.0163257,-0.0031128945,0.0430944,-0.027861156,0.048482966,-0.06273006,0.037557237,-0.07288581,-0.022773808,0.03789474,0.11142054,-0.060370717,-0.07578593,-0.013768339,-0.093854286,-0.089522466,0.013104832,0.00097475987,-0.036609165,0.016931904,-0.050445423,0.047934666,-0.036062267,0.036482807,0.05121892,-0.067007385,0.014011036,-0.014407661,-0.028145308,0.020904422,0.019640157,-0.0012734582,-0.014470757,-0.010833002,-0.015731722,0.036025543,0.0948513,-0.10040135 +1.14.11.19,"The enzyme requires Fe(II) and ascorbate. It is involved in the pathway by which many flowering plants make anthocyanin flower pigments (glycosylated anthocyandins). The enzyme hydroxylates the C-3 carbon, followed by a trans diaxial elimination, forming a C-2,C-3 enol. The product loses a second water molecule to form anthocyanidins. When assayed in vitro, non-enzymic epimerization of the product can lead to formation of dihydroflavanols. Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin and (+)-epitaxifolin are formed. The enzyme can also oxidize the formed (+)-taxifolin to quercetin (cf. EC 1.14.11.23, flavonol synthase) [2,3].",384,0.99999994,-0.074870184,-0.031329714,-0.11826964,0.06029641,0.12272801,0.025349887,0.0141970785,0.008393122,0.010052814,-0.043429963,-0.020263737,-0.012081472,-0.10167816,-0.011307472,-0.09033979,0.02634868,-0.07953302,0.0768437,-0.09425702,-0.033676542,0.04990716,-0.10469926,0.0075579304,0.031757403,0.014123783,-0.028097315,-0.01955195,-0.019313576,-0.03474315,-0.0674864,0.016198853,0.031274993,0.04945455,-0.045215197,-0.0368818,0.042061977,-0.04008959,-0.058661748,0.029173823,-0.036073048,0.006545643,-0.008373858,-0.03837911,-0.048241343,0.0050931904,-0.060814753,-0.040771898,0.02290387,0.017965382,0.05523275,-0.05129469,0.015808742,-0.05670896,-0.008871954,0.041328624,-0.0012282688,-0.02642422,0.05286716,-0.007905784,0.07277201,-0.002054735,-0.018457167,-0.060588893,0.00045344606,-0.03146781,-0.047832232,-0.06285291,-0.02825747,0.08360841,-0.015334933,-0.022518545,-0.008982492,0.0091001745,-0.012103185,-0.0034004324,0.15798762,0.0010333873,0.068598725,-0.007539394,-0.037385125,0.06016913,0.011806238,-0.018778576,0.09047643,0.035001643,0.011185286,-0.03491906,-0.0026117016,0.002937592,0.12603745,0.12305813,0.06463626,-0.058837704,-0.0049641095,-0.0519179,0.054116428,0.13725956,-0.059349474,-0.005306207,0.005744228,-0.045673035,-0.012718182,0.070923395,-0.08182657,-0.038630936,-0.021038873,-0.007231182,-0.021974321,0.043470293,0.0036463675,-0.010866788,-0.026022313,-0.015167451,-0.013047963,-0.027133642,0.04831057,-0.032373965,-0.016703192,0.010131195,0.0009423032,-0.03447215,0.03182238,0.030247072,0.008333597,0.0031461867,-0.013267206,-0.06468143,2.5477643e-33,0.0664816,0.035673384,-0.028391564,0.023959626,0.012001164,-0.005733357,-0.02503266,0.07300953,0.00037962984,-0.07115113,-0.06071702,-0.06604351,0.0050016223,-0.019817429,-0.030719241,-0.025666326,0.005513285,-0.13423316,0.058935165,0.034831468,0.08475969,-0.012330473,-0.15824874,-0.010071654,-0.029408475,0.032970123,-0.024798395,0.048697866,-5.154941e-05,0.025430433,0.041370925,-0.07011946,-0.022504432,0.0328144,0.082104556,-0.0052258084,-0.014002287,-0.040088724,-0.026745006,0.06462467,-0.00874075,-0.012355806,-0.004492107,-0.03155695,0.0008910911,0.0023357437,-0.034963474,0.07797214,0.06834543,0.078796476,0.043351565,-0.02602908,0.12621099,0.048372116,-0.06740673,0.023236077,-0.027943473,-0.079454795,0.050432988,0.024273826,0.01477399,0.014739745,-0.012416358,0.0145346895,-0.009513652,0.0441747,-0.13012575,0.0034046427,0.055026423,-0.025134163,-0.01518039,-0.06507704,0.047321446,0.025940692,0.07932512,0.015268165,-0.07889679,0.07368719,0.04110035,0.044013422,-0.014401416,0.019075258,0.012761211,0.031458292,-0.05405843,0.013372371,-0.008874405,0.034641568,-0.042914897,-0.0015644018,0.07351116,-0.079519056,0.03554241,-0.021477418,0.05161859,-3.900042e-33,0.11149469,-0.0415256,0.033599075,-0.026726715,-0.02983464,0.059713893,0.044325553,-0.09237113,-0.009589312,-0.025780804,-0.0016689888,0.011680786,0.074498594,-0.025909932,-0.032700893,-0.0027805218,-0.0031772354,0.1042664,0.026144575,0.05744244,-0.06705447,0.05569085,-0.016902914,0.005942474,0.05084976,-0.03316013,0.040044714,0.007895563,0.00016252573,0.07979196,0.0077334843,-0.021141479,-0.04643687,-0.028502617,0.022238549,0.0289393,-0.03504202,-0.031788524,-0.03465199,0.025425235,-0.061551042,-0.08570638,0.0007939088,0.056802873,0.08841013,0.0530314,-0.0658852,0.06300769,-0.007410493,0.033740878,0.01848646,0.043514173,-0.058003347,0.08370592,0.024143364,0.007435797,0.096128315,0.010234893,0.017716516,0.010515202,-0.046516225,-0.12272179,0.0075100465,0.018173799,0.015907519,0.07198958,0.021571053,0.11758541,0.07755527,-0.07982245,0.09075289,-0.011972617,0.10279955,0.05904303,-0.052449334,-0.008399624,0.018603986,-0.013265328,-0.052991297,-0.032694206,0.011577869,0.01706492,-0.028995162,-0.05101395,-0.076553285,-0.080228984,0.052550856,-0.012446683,-0.093198635,0.0061386963,-0.0074451054,0.011471954,-0.06970285,0.0920644,0.101431444,-4.501456e-08,-0.07752298,-0.07593617,0.032566912,-0.065453276,0.04812984,-0.0015326852,0.0075546606,0.012982123,-0.024448672,-0.05681937,-0.020825181,0.07811099,-0.006629717,0.049621027,0.032982435,-0.028698964,0.07273648,0.04556066,-0.030578684,0.022468107,-0.122528225,-0.041769832,-0.15213434,-0.055948097,0.009123862,-0.07547399,0.014011511,-0.010243521,0.041090965,0.0046565547,0.02806591,0.03180065,0.018951045,0.0028529703,-0.08069778,-0.01539081,-0.031495415,-0.08650846,-0.038985755,-0.041054912,-0.008431841,0.023552792,0.014025924,-0.01843494,0.01778519,-0.054980487,0.014448067,0.046113294,-0.025258377,0.048794284,0.06783422,0.00034528415,0.012746441,-0.085988194,-0.01924765,-0.028148066,0.045448568,0.013569202,-0.024261827,0.022204867,-0.077053495,0.016802598,0.14643568,-0.01659021 +1.14.11.20,"Requires Fe2+ and ascorbate. Also acts on 3-hydroxy-16-methoxy-2,3-dihydrotabersonine and to a lesser extent on 16-methoxy-2,3-dihydrotabersonine.",384,0.99999994,-0.039448895,-0.06828119,-0.038416304,0.056491412,0.026513696,-0.018855348,-0.00021917961,0.017743917,-0.0013993696,-0.08313281,0.037056047,-0.037134744,-0.077181734,0.06677207,0.031545434,0.010603088,0.045865797,-0.03296218,0.00941415,0.046764236,0.086252555,-0.061876617,0.035286747,-0.029913615,-0.018513033,0.036787514,0.00080381456,0.013045467,0.012292841,-0.07873595,0.023457723,0.0322856,0.015563062,-0.050142616,-0.008593953,0.057731472,-0.05514211,-0.028670002,0.042630263,0.07855382,0.05223231,-0.06934321,0.019821147,0.029933803,-0.0122204535,-0.0871818,0.022988474,0.002870701,0.039141856,0.027788613,-0.08607532,0.039590042,-0.025333984,0.07796253,0.00058402895,-0.025605135,-0.038452625,0.023120055,-0.030292308,0.036319055,-0.067773074,-0.0545253,-0.047700047,-0.019438362,0.024361962,-0.04620504,0.0030988317,-0.05679258,-0.0017358116,0.059249118,0.0018886473,-0.009796696,0.010758844,0.023429094,-0.008984793,0.049451005,0.012350792,-0.03458074,0.052206807,-0.069595546,-0.03744452,-0.028619288,0.024955085,0.10201256,0.09281422,0.046084985,-0.08572268,-0.068362646,-0.109668866,0.09480249,-0.035114273,0.013113233,-0.080581985,0.028891692,-0.047699824,0.015250074,0.07544772,0.012193048,-0.03359827,0.028108217,-0.050730668,0.08739201,-0.08274167,-0.018694922,-0.02672718,-0.046385307,-0.03319447,-0.0123209115,-0.009201043,0.018693767,0.026867773,-0.039683416,0.012466799,-0.013782388,-0.047165293,0.079107895,0.037516184,-0.09240018,-0.022472307,-0.051487215,0.04005788,-0.044628784,-0.0035510696,0.0620576,-0.10302311,0.025347354,0.010483431,2.7536337e-33,0.04411848,0.075296916,-0.0003667253,0.062929176,-0.033368677,0.057856437,-0.10180296,-0.003852248,0.019095115,-0.075365275,-0.031795267,-0.044554863,0.064762324,0.0030307847,-0.03829053,-0.111749366,0.007816915,-0.063268065,0.08107701,-0.06753984,0.08380137,0.061051015,-0.050977804,-0.00045787703,-0.10058594,0.026958205,-0.021337245,0.05056429,0.042047888,0.012918003,0.066698164,-0.03677115,-0.03350663,-6.03517e-05,0.018716877,0.05468234,-0.09699606,-0.08002497,-0.022682933,-0.00951448,-0.005063506,0.06919214,-0.060037058,-0.059717078,0.0432848,-0.03563428,-0.015331852,0.070438944,0.049677636,0.05468496,0.05242415,0.022231149,0.094488315,0.010179069,-0.042329922,-0.008877582,-0.035447005,-0.07949129,0.06470969,0.07122112,0.020340849,-0.01899072,0.01229856,0.025861252,-0.061819777,0.06622878,-0.021886507,0.022972167,-0.024182178,0.045337867,-0.035444535,0.045613743,0.055111557,0.017166864,0.022951534,0.008480593,-0.07530965,-0.0047216625,0.05447187,-0.03840428,0.017809143,-0.04109946,0.04619476,0.051894773,-0.06559733,0.032051504,0.018392691,-0.0067263697,0.04201158,0.02742783,0.030838542,-0.082776815,0.018326038,-0.06270257,0.05826647,-4.0832578e-33,0.0026790702,-0.044923738,0.019431366,-0.022398856,0.018318595,0.062041696,0.08035993,-0.14137395,0.00874492,-0.02570365,0.10571074,-0.03395703,-0.02556011,-0.10615484,0.037238546,0.0564136,-0.09485598,0.05910067,0.02580159,0.027132995,0.04058008,0.11027772,-0.011131486,0.1753694,0.020257136,0.0055603213,0.0063058427,-0.06322383,0.018378695,0.09063838,0.042398933,0.0034483161,-0.047370665,-0.054526545,-0.028111916,0.04250801,-0.05385627,0.038958788,-0.040554024,-0.019362302,0.020829102,0.0097054485,0.06048727,0.14373499,0.0049064816,0.043181367,-0.068021744,0.019337673,-0.041131463,0.09389908,-0.023899244,-0.09525174,-0.100968055,-0.00852083,0.011227198,0.050523106,0.034445222,-0.034035876,-0.02207709,-0.017353563,-0.014407598,-0.05176546,0.0028302828,-0.07761695,0.058152292,-0.02573835,-0.022427967,0.076767534,0.09630145,0.049080446,0.039380316,0.06159598,0.061063632,-0.04302482,0.010142614,-0.03240778,-0.014930606,0.018480591,-0.050885405,-0.014058313,-0.033233345,0.03607148,0.0002622201,-0.019160943,-0.04654542,-0.09355432,0.024880387,0.02288,-0.05825357,0.027068267,-0.043999285,-0.002574873,0.021902738,0.033601303,0.05439129,-4.270663e-08,-0.042772733,0.00020596608,0.041650984,-0.006889815,-0.0091360845,-0.03205571,0.048187032,-0.022254035,0.0041619446,-0.054338228,0.05070752,0.087719575,0.09385787,-0.029935054,0.043162372,-0.07203275,-0.008266961,0.09215493,-0.060535148,-0.04902678,-0.11778919,-0.03462862,-0.08498409,0.021461006,0.008282112,-0.016107492,0.0014083098,0.0072020753,0.049080387,-0.03630678,0.073043235,-0.02279151,-0.022435492,-0.052950762,-0.123994686,0.018580917,-0.04935562,-0.018706124,-0.03146639,0.0035205898,0.0035219768,-0.02456269,-0.030849647,0.059046473,0.0061919624,0.00026590106,-0.06343161,-0.003283991,-0.039247457,0.100435875,0.024346074,-0.007339808,0.062291484,-0.055702545,-0.043872055,0.022475518,-0.048335068,0.008218033,0.03375108,-0.09244261,0.055840865,0.00080250204,0.1391896,-0.018677752 +1.14.11.21,"Contains nonheme iron. Catalyses three separate oxidative reactions in the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site.",384,0.99999994,0.026931874,-0.049695652,-0.113247894,0.036406845,0.089734554,0.052493814,-0.042765502,-0.0016162348,0.050820075,-0.0713865,-0.012689991,-0.0545182,0.03665541,-0.0691134,-0.040116284,-0.011834985,-0.042905767,0.03931135,0.042082414,0.017847277,0.06333175,0.015005291,0.056215536,-0.011682702,0.05684277,0.10838836,0.05864412,-0.022944076,-0.05990233,-0.040426854,0.024156068,-0.024274938,0.047262672,-0.02319141,0.017022561,0.030731296,-0.053102747,-0.07019065,0.060320795,0.022647822,-0.005440507,0.026230834,-0.036585577,-0.010830813,-0.0006013824,-0.06030436,0.017718188,-0.012828079,0.0024934928,-0.06895366,-0.033765107,-0.09699803,-0.11287416,0.010177923,0.04246475,0.011170917,0.013814051,-0.008137232,0.036290824,0.0049734227,0.03339625,-0.0058276774,-0.0040834527,0.00018727577,0.005847222,-0.058440942,0.032246847,-0.07860953,-0.0060938587,-0.024349347,-0.034876,-0.013814488,-0.038209923,-0.02577809,-0.0035783264,0.05977138,0.07480662,-0.041310575,-0.05897014,-0.048191726,-0.018629601,-0.00825042,0.014749761,0.090727575,0.0317004,-0.004632425,-0.017014109,-0.017596748,0.06975232,0.078130774,0.024515247,0.068158165,-0.02460766,-0.00788008,-0.09214951,0.050408058,-0.009121154,0.042733394,0.027493093,-0.018731287,-0.044795934,0.07098746,0.010533326,-0.052836213,0.016282251,0.048180547,-0.010671765,0.10419561,-0.008142311,-0.012452685,0.04801889,-0.05303879,0.02670306,0.019231427,0.0173504,0.07479443,0.12024813,-0.056017682,-0.020983644,-0.0021277692,0.05561798,0.010654128,0.03783424,-0.0057172216,-0.074571766,0.04837727,-0.083661556,4.938859e-33,0.01945849,0.034816224,0.009799386,-0.04419836,0.014874822,0.025402779,-0.10040465,-0.011450913,0.04676359,0.0033112464,-0.07304492,-0.04308687,0.028125336,-0.018188238,0.028931702,-0.067898996,0.03929626,-0.0072996444,0.053170368,0.01781108,0.018613953,0.0057389108,-0.028308889,-0.010513861,0.011984539,0.024589643,0.02531614,0.04241898,0.058789685,-0.033528168,0.049082074,-0.05727192,-0.1063667,-0.0026495424,0.058199152,-0.03723188,0.0009808012,-0.015979806,-0.024196796,0.061162952,-0.0515994,0.011780557,-0.06520265,-0.038255095,0.06308847,-0.10878788,-0.054154735,0.118644625,0.02764572,0.0850014,0.002991778,0.0041715074,0.12761772,0.035659306,-0.06610442,0.037207905,-0.030213041,0.011569897,0.07288096,0.054272186,0.010026667,0.029724412,0.033124976,0.009054202,0.038901933,0.032033335,-0.05601291,-0.025114661,0.007546884,0.03611055,-0.057110265,0.027647063,0.07366101,0.0006249409,0.048060793,-0.061455205,-0.090070635,-0.03045862,0.044665124,0.027537739,-0.016686091,0.040324934,0.021378415,-0.026393913,0.0095826695,0.08882966,-0.099075735,0.0022250498,-0.019225301,0.010747772,0.004637668,-0.0007741302,-0.05536562,-0.03798598,-0.0064935656,-4.085476e-33,0.12010993,-0.080220975,0.052493025,-0.08499929,-0.08928041,0.03758802,-0.096974336,-0.08762373,-0.05144622,-0.047976486,0.029530145,-0.04437178,0.01475342,-0.12073497,-0.015023348,-0.016856277,0.00077506155,0.1349573,-0.05903196,0.0052798497,0.060594022,0.07988715,-0.008623295,0.035364375,0.041701365,-0.04456062,-0.0073791826,0.026244026,0.054538354,0.09929634,0.052594934,-0.018606726,-0.026709821,-0.08313574,-0.03876889,0.058683224,-0.03233248,0.046496145,0.10328252,0.071005866,0.028924283,0.0031519,0.021816969,0.06905216,0.03435407,0.06383274,-0.10042662,0.0032383043,0.0326187,-0.010194338,0.008237378,-0.00042798975,-0.06787983,-0.02132772,0.07261789,0.01120604,0.019031571,-0.029413808,0.04544697,-0.088133775,-0.046550367,-0.040377535,0.09602914,-0.065152355,0.083393306,0.06679994,-0.022899866,0.12816335,0.08242981,-0.06982742,-0.024213348,-0.032150485,-0.05912529,0.018331293,0.022513498,0.004625177,-0.03138591,-0.014293793,0.01189299,0.028447729,0.031111315,-0.018687092,0.026346846,-0.060997047,-0.038646698,-0.09963362,-0.011563977,0.035439912,-0.05487479,0.0016044147,-0.0062046964,-0.05420434,0.07958687,0.08090007,0.05350664,-3.7430713e-08,0.004795669,-0.05282726,0.053364858,0.01057722,0.029762698,0.031220898,-0.073378704,-0.081691615,0.04506853,-0.038050048,-0.049652364,0.02991019,0.004339322,0.01975073,-0.0058197062,0.036760073,0.028917588,0.02194391,-0.027167909,-0.007920506,-0.072097816,-0.011297862,-0.10271426,0.07025649,0.10382537,-0.10041283,-0.015837507,-0.0024228685,-0.008706081,-0.0026739887,-0.020838518,0.029248618,-0.0003892629,-0.036130715,4.8474798e-05,-0.05047564,0.0010316046,-0.013500644,0.005746077,-0.005686976,0.0010668673,-0.050744276,-0.050219428,0.015917055,-0.07039972,0.03965868,-0.017588336,0.023976693,-0.07672743,-0.035304267,0.12547886,-0.03885185,0.053962108,0.014394071,-0.09482184,0.10389064,0.06969232,-0.07708696,-0.026128527,-0.029021902,0.022275232,-0.011731814,0.1593837,-0.06397579 +1.14.11.22,Requires ascorbate for full activity and Fe2+.,384,1.0,-0.002324426,-0.05699196,-0.046426926,0.10652402,-0.00963605,-0.008684468,0.039823852,0.056528665,-0.038811147,-0.026527127,0.041274004,0.009479037,-0.100571625,0.052202,0.036831647,-0.01869618,0.12623084,-0.0640004,-0.00056683173,0.04734916,0.12632483,-0.004446664,0.09834811,-0.033603724,-0.062234905,-0.0015815926,-0.077280544,-0.052760523,0.048765447,-0.09526466,-2.108027e-05,0.018701205,0.053780887,-0.057793453,-0.068994395,0.014280159,-0.026299147,-0.023731627,-0.031109193,0.006040459,0.021000301,-0.06758194,-0.017946348,0.03933214,0.013000534,-0.028541159,0.06641228,-0.07813675,0.052919146,0.07832154,-0.03567397,-0.011263902,0.018912302,0.06634329,-0.046202723,-0.008203076,-0.066573314,-0.038808845,-0.047817476,0.036893398,-0.07217961,0.0071314247,-0.044539344,0.024968727,0.02275218,-0.011344244,0.005059626,-0.044230767,0.0060474244,0.017607618,-0.03994778,-0.012453379,0.004302893,0.07366862,0.006869517,-0.026696503,0.0381562,-0.058749307,0.035217565,-0.013846509,-0.04594484,-0.03346669,0.003126178,0.06818481,0.049579285,0.061071403,-0.027950192,-0.026490595,-0.11125619,0.10827822,-0.006585015,0.04119343,-0.04374156,0.006389008,-0.045545522,-0.024177777,0.0054202876,0.004205565,-0.067576855,0.012952323,-0.044570643,0.061485104,-0.055962004,0.044185974,-0.033871263,-0.07397371,-0.07549303,-0.0048377183,0.03941027,0.016006282,0.020824667,-0.00732806,0.0037668843,-0.0021119653,0.03600583,0.0927527,-0.020837864,-0.007314623,0.0069003785,-0.0046511632,0.050794855,-0.021992628,-0.03792932,0.035952095,-0.057851374,-0.0687266,0.04262611,-3.3832038e-34,0.04266596,0.08936288,0.042831354,0.051234722,-0.07959571,0.08265206,-0.054417826,-0.025088588,0.061981253,-0.05560988,-0.011211632,-0.047148198,0.027631978,0.0870706,0.024212632,-0.14416079,0.01995157,-0.016510157,0.09674661,-0.055832792,0.07637975,0.031950854,-0.017385332,0.039227717,-0.06835636,0.06174622,-0.0034600636,0.02706411,0.011568504,0.023210607,0.02573742,-0.027386473,-0.07083649,-0.07875351,0.058961295,0.055842042,-0.026382152,-0.05042081,-0.031532627,-0.022515943,-0.036251746,0.066317424,-0.09390049,-0.04503437,-0.030964185,-0.074725494,-0.0036026696,0.034748968,0.034408346,0.057304047,-0.00078693795,0.0426725,0.102449775,0.0031499928,0.0055763563,0.04760839,-0.0074949935,-0.046910748,0.017381407,0.079235695,0.08301777,-0.0049838675,-0.011236211,0.04656805,-0.10663615,0.08323355,-0.022170106,0.01229089,0.0023435983,0.0064973817,-0.06633338,0.050919216,0.053940974,-0.0072427564,-0.009424042,0.02314251,-0.080023624,-0.03624761,0.033108637,-0.0078603225,-0.018931521,-0.07028805,-0.014857533,0.03184851,0.011804474,0.0038033312,0.011679168,-0.027747381,0.024246586,-0.03941917,0.015694505,-0.040496577,0.004023314,-0.0634908,0.059454914,-1.0560796e-33,-0.023912236,-0.07105636,-0.019436656,0.062313166,0.046010397,0.076009706,0.045110468,-0.104973435,-0.059996024,0.0325191,0.031577468,0.03075987,-0.0078866305,-0.049388044,0.058575436,-0.0025635562,-0.082922764,0.05693055,0.06786179,0.039961267,0.012343491,0.13674448,0.036250535,0.07852174,0.013251437,0.034585718,-0.08033413,-0.025101578,0.011055496,0.057975743,0.101730846,0.024602026,-0.10889683,-0.102054626,-0.07653539,-0.0047687595,-0.03397901,0.0629898,-0.05372296,-0.052068777,0.019712053,0.025876295,0.01464733,0.14190966,-0.024658054,-0.001449732,-0.048069976,0.019255493,0.030464234,0.081221275,-0.0068331975,-0.073734805,-0.082615264,-0.07171888,0.021001786,-0.027432764,0.034238826,-0.061339404,-0.023317797,-0.014734373,0.01203281,0.0057054176,-0.0212293,-0.067504615,0.06915632,-0.023903525,0.051975943,0.1097741,0.06836905,0.038052253,0.021294821,0.078705974,0.063167326,-0.070060045,-0.007178164,0.014664042,-0.0071748164,-0.020347372,-0.0064236685,-0.027814638,-0.108556345,-0.031137172,0.0012405126,-0.018870112,-0.036216322,-0.084513165,0.008042063,-0.01524135,-0.064498596,0.046278782,-0.06576744,-0.030524064,0.05763844,0.07455053,0.0009815249,-2.0193145e-08,-0.06266808,0.02856892,0.048181005,-0.0070309406,0.014227337,0.014999843,0.03454087,-0.041837715,0.0041530514,-0.029906293,0.035659093,0.07545561,0.1575219,0.03502224,0.040114697,-0.03406597,0.04739888,0.109307565,-0.06333602,-0.04560662,-0.077213034,-0.07716688,-0.08251741,0.017397465,0.003226037,0.013510827,0.04266723,0.02861142,0.07125201,-0.058973324,0.039772145,-0.03053421,0.028785279,-0.02644089,-0.07440124,-0.0038947435,0.008926365,-0.0057630897,-0.047526803,0.012360227,-0.043723915,-0.05787746,0.034581013,0.062479183,-0.05092263,0.002759719,-0.007174932,-0.058687337,-0.048314102,0.065901384,-0.0035689974,-0.021028563,0.010061163,0.009818466,-0.013389058,0.10071023,-0.014083506,-0.009361038,0.0646945,-0.059695,0.06469229,-0.025505794,0.04224089,-0.034628022 +1.14.11.23,"In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from the satsuma Citrus unshiu also has a non-specific activity that trans-hydroxylates the flavanones (2S)-naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively [2]. Requires Fe2+.",384,0.99999994,-0.040528055,-0.094521485,-0.11272462,0.08081489,0.0278853,0.08982839,-0.11990538,-0.0031781273,-0.0026147142,-0.10357134,-0.037529416,-0.061281867,-0.080417894,-0.07280789,-0.043758526,0.012690494,-0.027788451,0.0844495,-0.08299885,-0.04889632,0.041119665,-0.08851831,0.018814327,-0.042065226,0.007714813,0.0031882632,0.032250874,-0.06662899,0.015470126,-0.109384835,0.09527292,0.026242407,-0.026469087,-0.002332696,-0.05571714,0.01589013,-0.04235969,-0.085043706,0.0022443708,-0.037159674,0.083888926,-0.014934799,-0.045144174,-0.044195842,0.051265463,-0.06876275,-0.09644393,0.012753324,0.07725539,0.034337524,-0.06294024,0.007559482,-0.01652011,0.08593831,0.041069157,0.028621214,0.04388345,0.015620534,-0.015891455,0.09001947,0.06563316,-0.05416652,0.008034468,-0.0062315455,-0.0713945,0.012028289,-0.052029684,0.015059065,0.027835077,0.043174896,-0.037754238,-0.0056784484,-0.0143730445,0.018172001,-0.018625923,0.04834042,0.012568,0.036355708,-0.014099485,-0.031649556,0.05423625,0.0045595877,0.03145829,0.056543466,0.017513106,0.025130006,-0.12026793,-0.02120314,0.022118488,0.16326272,0.007557501,0.07468199,0.004833804,-0.058139946,-0.010515496,0.036654994,0.015094074,0.005505533,-0.02836566,-0.016726281,-0.0054284954,0.053398654,0.02195391,-0.081370555,-0.09093028,0.00080607156,-0.06124599,-0.055228308,0.006929481,0.053701162,0.05908599,-0.054125946,0.036233824,-0.07636503,-0.08341278,0.042101976,0.013166812,-0.034309775,-0.010841655,-0.043693677,0.012572194,-0.039887432,0.012460061,0.015460028,-0.010357651,-0.03394829,-0.044321556,4.7376834e-33,0.035482682,0.017851988,-0.056192584,0.067244865,0.055732805,-0.0681241,-0.08040544,0.034124102,0.051805858,-0.047133747,-0.11076342,0.029852012,-0.049409445,-0.021983366,0.029904835,-0.061658125,0.04245643,-0.073649794,0.068411276,-0.08278092,0.058846805,-0.013065101,-0.072893135,-0.0021334544,-0.0678739,0.0036034205,-0.003218896,0.010497231,0.030580513,-0.029161671,0.024336312,-0.10300794,-0.017636536,0.063723214,0.023299236,-0.014296867,-0.036793116,-0.039833207,-0.030494627,0.09237489,0.029221,-0.009181664,0.037681356,0.044535283,0.03863619,-0.06328949,-0.067127906,0.03062125,0.057027206,0.035689104,0.0069558243,-0.0031877377,0.10349785,0.038976677,-0.006969535,0.016088556,0.016575772,-0.0075861607,0.05341127,0.04643784,-0.06768358,0.015186867,0.027534764,0.029706933,-0.059467927,0.055735145,-0.0783354,-0.0008205875,-0.013325647,0.01391474,0.008095989,0.018750671,0.09207906,0.04252665,0.09458374,0.0022237974,-0.048143834,-0.009178644,0.053469274,0.044725582,0.0042137797,0.029879652,0.0054275594,0.116971135,-0.0773312,-0.032372776,-0.07084015,0.026705544,0.040457986,0.00786598,0.054984257,-0.04857319,-0.025145339,0.020426702,0.061421324,-5.0790422e-33,0.031495016,-0.069087654,0.03043653,0.02298981,0.012115026,0.038740482,0.0047927643,-0.061976817,-0.0012263559,0.033539344,0.07952998,-0.032778714,0.021041946,-0.052965187,0.022749553,0.04264907,0.07823533,0.13506521,-0.09563896,-0.02570087,-0.015226308,0.07898104,-0.009901165,0.019433957,0.033685263,-0.007148683,0.060174037,-0.00030519627,-0.002990039,0.119991824,0.08103672,-0.006673846,-0.065396205,-0.05741726,-0.0060296296,0.03396407,0.03328708,-0.0108669745,-0.05479594,0.06901759,0.006114317,0.0034706045,-0.0142049,0.07523536,0.067458756,0.05073865,-0.097720884,-0.02485572,-0.0014214488,-0.01184439,0.057164896,0.043749,-0.050508372,0.08712231,0.04581747,0.01444742,0.053893335,0.004032398,-0.0060624443,-0.010671018,-0.015613702,-0.12654345,0.030656936,-0.078120135,0.021226075,0.035787147,0.040477525,0.101629734,-0.0095944125,-0.017525664,0.06162703,-0.051400088,0.038307276,0.09440022,-0.011771752,-0.037904352,0.0042271884,0.039259844,-0.0364846,-0.024723647,-0.0051491307,-0.06512851,0.0066245347,-0.09054754,-0.009481768,-0.06553105,0.0042652334,-0.0052070166,-0.026393605,0.005485901,-0.0015558542,0.019423375,-0.09799969,0.032000598,-0.0027786456,-4.554954e-08,0.0024319394,-0.1084501,-0.0021122335,0.01278953,0.06526308,0.0045981803,-0.0659157,0.012022575,-0.045979407,-0.02481776,-0.0884813,0.0525095,0.00590664,0.0033613674,0.061843023,0.0076568057,0.10323979,0.07687985,-0.0041981502,0.024798885,-0.03843637,0.053114235,-0.1011377,-0.07075143,0.009488013,-0.04677802,-0.061784793,-0.023877447,0.13948269,0.0140147265,0.032552272,0.036115214,0.007434877,-0.012240767,-0.11397373,-0.011021268,0.05558365,-0.011619213,-0.06409742,0.02156884,-0.067351036,0.030042194,-0.04053324,0.06381698,-0.055281777,-0.037488278,0.00092385686,0.05101721,0.0057281055,-0.01154893,0.037966084,-0.02963495,0.014437931,-0.022668598,-0.0476698,-0.052009467,0.014026044,0.0038779322,-0.024357308,-0.018309366,-0.020988591,0.0052338257,0.08171631,0.018916154 +1.14.11.24,Requires iron(II). It is also likely that this enzyme can catalyse the hydroxylation of 3-epihydroxy-2'-deoxymugineic acid to form 3-epihydroxymugineic acid.,384,1.0,-0.019587582,-0.07613846,-0.08915649,0.024447499,0.06757857,-0.01903651,-0.052222177,-0.028813833,0.008560833,-0.03467528,-0.0127037065,-0.077071,-0.009770062,-0.03909472,0.04235913,0.0066114236,-0.07593115,-0.0023655817,-0.015521642,-0.01855048,0.042557202,-0.053501908,0.055103343,-0.022834657,0.002703865,0.022553323,0.08052167,0.021963745,-0.02047664,-0.077573664,0.06220044,-0.07190002,-0.008571878,-0.054972608,-0.004141875,0.056651775,-0.071428694,-0.055586,0.03371904,0.018135212,0.0016267244,-0.037254736,-0.024694981,-0.040155113,-0.03702203,-0.09716395,0.03868065,-0.0044984277,0.057174183,0.025004825,0.004109474,0.01934302,-0.053958867,-0.011940438,-0.037415747,-0.021951905,-0.042812135,0.025353268,-0.06633159,0.08393095,0.039636433,-0.00896182,-0.024432935,0.0066367015,0.019722579,-0.06815841,0.037254706,-0.10637821,-0.02420926,-0.01699758,-0.025193144,-0.027200164,-0.059022956,0.026238946,-0.0026644059,0.04230405,0.0015552081,-0.062502995,0.052329175,0.007948808,-0.021708943,0.022252444,-0.0086748665,0.13040781,0.05256818,0.02272623,-0.012750952,-0.03990498,-0.029075272,0.075298406,0.031966887,-0.034159698,-0.045407716,0.045213,0.06784418,0.061202098,0.021355951,0.01604973,-0.008501288,-0.019437358,-0.07168135,0.08038476,-0.023289831,-0.06385305,-0.04653114,0.021302471,-0.038611114,0.11621213,-0.0036575212,0.026174964,-0.0070311176,-0.08519995,0.03568299,0.01194595,-0.049656108,0.16422497,0.063534535,-0.10569962,-0.053171873,-0.021392027,0.06275284,0.0021788094,0.017284168,0.05557093,-0.052887794,-0.01916368,3.1688065e-05,2.7002115e-33,0.015304119,0.06946591,0.001352116,0.005514724,-0.029555805,0.101270236,-0.15168412,0.0018215976,-0.06148874,-0.013071171,-0.06198807,-0.024781246,0.10676842,0.03807884,-0.058892656,-0.046493005,0.031859834,-0.02680697,0.090692356,-0.0023713748,0.04234548,0.011040954,-0.003373076,-0.056357995,-0.064565286,0.09371819,0.050955005,0.029218292,0.11659436,0.0062104333,0.035142213,-0.111405745,-0.06596661,-0.012990608,0.036009677,0.015853085,-0.015902089,-0.0106430305,-0.014022057,0.07734784,0.062368497,0.016012955,0.0054779393,-0.07356956,0.07201089,-0.07459023,-0.006089775,0.094326094,-0.027309464,0.0723573,0.06645497,0.034383588,0.074517064,0.013430186,-0.049380843,-0.03483731,0.0038233015,0.0013686916,0.052241556,0.044467226,-0.011985001,0.020772042,0.00964159,0.072639704,-0.017213646,-0.0015230916,-0.032677222,0.04647757,-0.043929923,0.07372524,-0.06588619,0.0170707,0.05731906,-0.0065938565,0.053325366,-0.037449475,-0.10255326,0.025686447,0.11626943,-0.0056826617,-0.053553104,-0.01006513,0.024331907,0.030467976,-0.07591016,0.011051214,-0.078810744,0.0076310225,-0.009474182,0.011766367,0.026332064,-0.05625422,-0.05496743,0.029865198,0.06501456,-6.325085e-33,0.05425443,-0.09222996,0.015774012,-0.15079424,0.021413675,0.0732695,0.0448901,-0.05248463,0.017762186,0.037239294,0.09223125,-0.08010103,-0.0043557417,-0.0773279,0.072375804,0.017020555,-0.0492882,0.072294466,0.011492341,0.0077681737,0.054034274,0.115286894,-0.0046839775,0.07658788,0.03481964,0.014417093,-0.024486786,-0.003296097,0.043123,0.13291116,-0.05071377,-0.060458682,-0.029767558,0.0020329687,-0.008260112,0.056890324,-0.028073594,0.011872381,-0.006071704,-0.006931539,-0.019552065,-0.019292135,0.029529337,0.07213761,0.058017477,0.08142841,-0.07124973,0.047445055,0.024711477,0.024346178,0.0028338737,-0.027875107,-0.061853886,0.01180338,0.039900776,0.015267405,-0.021045629,0.011446417,-0.008426552,-0.03634246,-0.081345744,-0.022140311,0.053199816,-0.050744884,-0.006153424,-0.001118692,-0.040080737,0.051153127,0.044260405,-0.040869802,0.031770922,0.0032204953,-0.015843738,0.004207052,0.035994932,-0.00073836034,-0.10187642,-0.016185477,-0.0071283984,0.0050082365,-0.011149238,-0.005514917,-0.0011133065,-0.002213231,0.031599026,-0.104886524,-0.007552543,0.048695847,-0.018329611,-0.013130473,0.007234423,-0.015585608,-0.03520988,0.046425514,0.07181502,-4.137673e-08,-0.048300967,-0.066977516,0.029388228,-0.048088383,-0.044735268,0.028925892,0.009435134,-0.023235584,0.019812884,-0.08546415,0.018217515,0.074649744,0.0036801086,0.067142464,0.011673229,-0.025072215,-0.01331671,0.030718049,0.0030771235,-0.086314015,-0.13516657,-0.07816396,-0.036786288,-0.0047180383,-0.0067590373,-0.04749174,-0.050861523,-0.0378461,-0.015080299,0.013879639,0.007280512,-0.0034350278,-0.05976072,-0.009528605,-0.109436214,0.005151748,-0.011117497,-0.004602176,-0.06009577,0.005824891,-0.0035047596,-0.011653308,-0.08499494,-0.005992077,0.028903054,0.000775863,-0.039031476,0.024916362,-0.027466426,0.004569066,0.057532154,-0.080577314,0.023503577,-0.042776108,-0.053485014,0.049494036,-0.0801555,-0.07412828,-0.022267003,-0.046938047,0.046121646,0.06309093,0.20523062,-0.063918196 +1.14.11.25,Requires iron(II).,384,0.99999994,0.0014523091,0.027252575,0.017929079,0.14652438,0.028499665,-0.07374985,0.044689853,-0.024867844,-0.044972967,-0.038950577,-0.007944057,-0.00930845,-0.039508447,0.042648185,0.023895964,-0.070207894,0.03478252,-0.044564117,-0.05675341,0.057358988,0.053185023,0.002313728,0.03796027,-0.029366715,-0.058299087,0.016295183,0.011448823,0.0595313,0.018484415,0.008140258,-0.005221072,-0.012147138,-0.06039624,-0.0028405336,-0.026067061,0.017309526,0.010601276,-0.036861863,-0.068499915,-0.018606562,-0.015039532,-0.11111492,0.019859834,0.019101424,0.014097741,-0.007364287,0.06008752,-0.012114141,0.015921555,0.049425174,-0.08074685,0.039302077,-0.015895054,0.05718556,-0.01385979,-0.0039961915,0.0108495,-0.029758504,-0.011128948,0.025854643,0.010918698,-0.07108024,-0.08090309,0.047503352,0.10147377,-0.028184576,0.054938894,-0.046469588,-0.06838021,0.039978802,0.007083465,0.03556207,-0.1379736,0.027731998,0.005539074,0.029246073,0.043913156,-0.05515014,0.08982839,0.027445488,-0.14043196,-0.0005275654,0.019506758,0.064473405,0.046654392,0.08633993,-0.0042501125,-0.041572694,-0.13786075,0.049790043,0.020294946,-0.019988356,0.015585006,0.051941156,0.06503691,0.010421412,-0.019767003,0.03375018,-0.10854892,0.033853635,-0.10367238,-0.0016567648,-0.053759914,0.051686544,-0.026726527,0.004622056,-0.044103406,0.00036654237,-0.003591875,0.023541052,0.022569235,-0.023933593,0.06838805,0.013870685,-0.008313731,0.049025256,0.07875068,0.016993912,0.0029642237,0.07624696,0.057215378,0.025888538,-0.009263245,0.015902126,-0.031328,-0.1355765,0.045060225,-6.394196e-33,0.016387064,0.03079215,0.05699989,0.04036546,-0.03762866,0.032003846,-0.12474885,-0.05322417,-0.010901688,0.019643623,-0.05535641,-0.011823006,0.013934648,0.0032307259,0.030237451,-0.063035145,0.11116909,-0.030703938,0.10299545,-0.042499516,0.06523321,0.029667115,0.06524572,-0.040416297,-0.03883727,0.07817232,0.048914894,-0.039703257,-0.029419739,0.04507585,0.044800516,-0.05833638,-0.01895969,-0.007811858,-0.0021943513,0.030469207,0.0016875152,-0.015753223,-0.046503153,-0.005475343,0.02135818,0.013856562,-0.014957764,0.01568572,0.10248507,-0.08834165,0.024694674,0.08417159,-0.02417116,0.07292593,0.0019015038,0.07003174,0.066555604,0.01728124,-0.0053855865,-0.024484891,0.025828423,-0.020529104,-0.0012035227,0.09663611,-0.009050834,0.042365696,0.053211834,0.14183725,-0.027597858,0.041049987,-0.06468994,0.060408056,-0.06501275,-0.012520816,-0.051135127,0.030415002,0.11675433,-0.01949768,-0.024545105,-0.0445555,-0.04547554,-0.03685935,0.038575336,-0.05949756,-0.052883167,-0.039195567,-0.029194878,0.016007364,-0.053043757,-0.029280432,-0.04170247,-0.0020592988,0.0845642,-0.065231234,0.006199312,-0.06046538,-0.0007473051,-0.09139075,-0.022749193,4.1639478e-33,0.00020910175,-0.0326671,-0.023898734,0.020729234,0.007994924,0.025245592,-0.014203039,-0.12578931,-0.035318017,0.045799673,0.07128179,-0.0391464,-0.011500358,-0.04711551,0.058107965,0.07241081,-0.044044692,0.05679117,0.038529664,-0.015383889,-0.022884656,0.08613345,0.057248645,0.06922727,-0.023207957,0.034127202,-0.0544015,-0.02746851,-0.017834343,0.07187955,0.017325997,-0.018496169,-0.08158515,-0.081566975,-0.060472548,-0.04690105,0.034349613,0.024487723,-0.038509686,0.0021187137,0.02820191,0.008290703,0.08784376,0.15234081,-0.03183167,-0.011680772,0.045052778,-0.013639911,-0.005673024,0.052165724,0.012678911,-0.10627482,-0.061664876,0.0071892412,-0.0053000827,-0.043398965,0.00017878384,0.038774624,-0.05023905,0.039956044,0.016429596,-0.0033799533,0.045510158,-0.01624218,0.043761186,-0.052542154,-0.032375436,0.09545709,0.08185468,0.031858724,0.01547778,0.07070013,0.092564225,-0.11593673,0.009264118,0.031142784,0.03909415,0.06736096,-0.032055814,-0.023993446,-0.09234198,-0.05039753,-0.026554387,-0.007218034,0.03772231,-0.1298595,0.003445029,-0.097242415,-0.020879513,-0.014344707,-0.07040379,-0.01950206,0.067094915,0.039922353,-0.010760454,-1.5617143e-08,-0.04493823,0.002795271,0.019648628,-0.05302319,0.0060290247,0.01207727,0.018367697,-0.020780537,-0.007784412,0.020311713,0.0011957579,0.08678758,0.11951801,0.025286961,0.065014906,0.019497944,0.022639645,0.058934376,-0.062303692,-0.0683609,-0.07021503,-0.07294208,0.019333972,0.048217777,-0.011219556,0.003934842,-0.024722993,-0.06129205,0.041724075,0.07906756,-0.0078302035,0.0070402822,-0.018332656,-0.03150886,-0.10910299,-0.027190175,0.027429353,0.04108503,-0.027549312,-0.02304325,-0.081277505,0.014852986,-0.07297852,0.04405214,0.02521566,-0.030940091,-0.06745954,0.02891074,-0.041366845,-0.0005734273,0.03461176,0.01498418,0.059721977,0.058256824,0.005071149,0.11200412,0.00538853,0.0029015644,0.035510294,-0.01081553,0.063558385,-0.0015410167,0.04271254,-0.08328148 +1.14.11.26,"Requires iron(II). The enzyme can also use 3-exomethylenecephalosporin C as a substrate to form deacetoxycephalosporin C, although more slowly [2]. In Acremonium chrysogenum, the enzyme forms part of a bifunctional protein along with EC 1.14.20.1, deactoxycephalosporin-C synthase. It is a separate enzyme in Streptomyces clavuligerus. ",384,0.9999999,-0.034637738,-0.029884046,-0.14625517,0.015592223,0.05286253,0.022662718,0.001519717,-0.015342223,0.02792298,-0.06497805,-0.041903257,-0.10563951,-0.044391382,0.0035890338,-0.055212714,-0.034068376,-0.034389693,-0.010016328,0.022705242,-0.050100308,0.03165421,-0.014031941,0.0015776545,-0.01712943,0.032960646,-0.026245238,0.03833035,-0.005687819,-0.035189863,-0.112689756,-0.021229591,-0.049202982,0.042922154,-0.04267573,0.04450077,0.069389775,-0.01719077,-0.047880635,0.038550496,0.008330975,0.040694,0.032472674,-0.03186617,0.024800496,-0.08115726,-0.0058128317,0.0032597368,0.08598741,0.04653588,-0.032106522,-0.03609049,-0.05303928,-0.05368102,0.06081244,-0.017083136,0.004390352,-0.033110797,0.0040057003,-0.038836505,-0.010417008,0.036246654,-0.026411753,0.008355861,-0.053612903,0.0035607975,-0.03955079,0.02566309,-0.07584516,-0.0065351585,0.0067122797,-0.06812515,-0.008463091,-0.077047765,0.07264842,0.042214658,0.107649505,0.032608584,-0.07512107,0.035615876,-0.026493553,0.0054369313,0.05698318,0.012867885,0.09730185,0.046002295,-0.0036016284,-0.006612943,-0.022051346,0.004345444,0.04647027,0.07105841,0.04190104,-0.014741347,-0.011542207,-0.011844331,0.05861473,0.002401889,0.035909537,0.040752046,-0.035908658,-0.06194498,0.034178082,0.025806451,-0.05293814,-0.07638253,-0.013003097,-0.011723709,0.08947899,0.057414737,0.014367603,-0.025570132,-0.03336762,0.030543271,-0.025563253,0.014437664,0.06141076,0.10797589,-0.11499901,-0.027242003,-0.024454908,0.05165377,0.0014306558,8.917057e-05,0.08921641,-0.034523692,0.050256167,-0.12531698,5.6141357e-33,0.040339142,0.043073494,0.018820066,-0.009523463,-0.0033793785,0.022649499,-0.07545584,0.018515807,-0.01018769,-0.07048917,-0.06863236,-0.086126305,0.042050954,0.00567833,-0.014141684,-0.08574897,0.031998828,0.030367875,0.07282445,0.039705157,0.053952623,0.07099908,-0.07119489,-0.04108066,0.06507508,0.043225054,-0.012932431,0.042900894,0.086894326,-0.030136716,0.07579241,-0.09335828,-0.12791848,-0.019469935,0.07576136,-0.040913865,0.00334003,-0.010660067,-0.0053517935,0.03725484,0.016873758,0.029749515,0.03396609,-0.03260973,0.057564355,-0.12221101,-0.044957716,0.09963567,0.06212557,0.018183751,0.061629947,0.022412894,0.11915574,-0.04336884,-0.023719069,0.041517794,0.003906628,0.0027931675,0.08232802,0.01508837,0.021448214,0.07623481,-0.010496418,0.06440207,0.057028953,-0.018587582,-0.06330934,0.022193199,-0.058006957,0.04022241,-0.039396,-0.0066282107,0.018832868,0.008012883,-0.005586994,-0.08397726,-0.10151254,-0.04905164,0.048244562,-0.002997243,0.047234423,-0.050801385,-0.010362649,-0.03944611,-0.052207,-0.003840751,-0.068614975,0.015975611,-0.0025093143,-0.017412033,0.032015465,-0.023633396,-0.074398376,0.006234083,-0.006519849,-6.2194796e-33,0.11773571,-0.08900504,0.029149707,-0.08034759,-0.08118847,0.08235344,0.007899155,-0.008830521,0.029828658,0.024553621,0.12511833,-0.055551603,0.017181652,-0.05434319,-0.009488543,0.013456426,-0.058519322,0.088221036,-0.000942116,0.03716916,-0.08131382,0.06697712,-0.013853537,0.033298735,0.05504238,-0.022895752,-0.020702993,0.13618526,-0.026187722,0.05127262,-0.034423508,-0.040973265,-0.015548706,-0.056477465,-0.0938983,-0.001045513,-0.023831917,-0.049632993,0.04329039,-0.045872234,0.0068093697,-0.020176189,0.04111242,0.11182695,0.04395451,0.060591776,-0.038138688,0.059769265,0.01776841,0.046201468,0.0075384597,-0.0075594685,-0.03616236,0.030782074,-0.003386208,0.036431745,0.030701773,0.05809403,0.026791114,-0.029417858,0.010291656,-0.044745814,0.027236048,0.028421784,0.105226874,0.016103143,-0.10433098,0.10077605,0.048542753,-0.041288137,0.020250542,0.006029798,0.018792734,-0.0006793861,0.014154076,0.03041964,0.0008188671,0.040581487,0.023117425,0.041503627,-0.015228116,0.00088124373,-0.003539192,-0.062216636,0.013057469,-0.047898114,-0.0022029723,0.028859695,-0.06369932,0.05162165,-0.016326297,-0.09968776,0.014508756,0.050852295,0.024601543,-4.519534e-08,0.04677596,-0.03847776,0.06963513,-0.12776859,-0.023039801,-0.06584054,0.03162516,-0.10323667,-0.019598486,-0.013967968,-0.037762832,0.04767889,-0.0012989321,0.024560755,0.021207439,-0.02794284,-0.013350619,0.058777615,-0.005939951,-0.0027611814,-0.05716125,-0.005597884,-0.13868569,0.09064661,0.052916445,0.015754718,0.025297502,0.025188824,0.054373868,0.037489034,-0.00944465,0.03436887,0.018919328,-0.022251042,-0.08909151,-0.017049385,-0.07887035,0.010097994,-0.08755228,-0.0054276935,0.04116003,0.006219015,-0.048430055,-0.05151484,-0.013762985,0.0007524512,-0.05032336,0.009356562,0.0067224884,-0.0009290235,0.07246318,-0.05700127,0.042940166,-0.02575157,-0.08584899,0.05367108,0.0007807646,-0.07158031,-0.046093475,-0.008057907,-0.0128677515,-0.009993355,0.20318685,-0.012704163 +1.14.12.1,Requires Fe2+.,384,1.0,0.0017429227,-0.0120922215,-0.038558863,0.09142432,0.06785902,-0.058863577,-0.01458679,-0.014261219,-0.07332533,-0.05796829,-0.011215821,-0.015509965,-0.07202684,0.04249708,0.024249421,-0.03321543,0.019945407,-0.020375494,0.030671543,0.04413522,0.05039896,-0.076645784,0.061869685,-0.0806471,-0.07299566,0.021112347,0.025108593,0.011541391,0.031364482,-0.07522699,-0.013137532,0.024824042,0.00782358,-0.025159573,-0.07306664,0.037389968,0.028623296,-0.041204736,-0.07766069,-0.044195645,-0.092444964,-0.051226787,0.004661776,0.019761538,0.016014727,-0.08959922,0.10965217,-0.073083736,0.07675235,0.025391651,-0.047817487,0.012119977,-0.019110482,0.06658772,0.051607575,-0.03403417,0.020699611,-0.032469366,0.0004800927,-0.011221626,-0.017793885,-0.06576893,-0.036475454,0.05335543,0.06464099,0.022822551,0.047862507,-0.07560602,-0.05039111,0.036225423,-0.025612224,0.03532552,-0.052344717,-0.028691012,-0.016723612,0.03522456,0.07033103,-0.055389967,0.12350712,0.0123082185,-0.123151205,-0.03510367,-0.03319499,0.027769485,0.08925549,0.071048334,-0.042034563,-0.054983024,-0.099674575,0.055655226,0.028191065,0.060977615,0.023211394,0.05470533,0.03721542,-0.0003429361,0.0072218375,-0.019805033,-0.08760099,0.06914633,-0.09391643,0.05948289,-0.02463003,0.067270935,-0.015539489,-0.028376048,-0.031077085,0.06590933,-0.0741654,0.0145040555,0.07959369,-0.0071991794,0.03405784,-0.004239101,0.03415664,0.02927697,-0.0066822385,-0.003935083,0.025430325,0.02711847,0.076907285,0.034331284,-0.06844991,0.025891433,-0.060349308,-0.089497626,-0.018967083,-2.074728e-33,0.03875058,0.09118988,-0.0090543805,0.06307697,-0.019233564,0.035965927,-0.06977131,-0.034298696,-0.03491918,0.013025775,-0.051146638,-0.037127115,0.012320491,-0.006813886,0.08286553,-0.12027711,0.062278084,-0.0055497363,0.08970242,-0.0406022,0.06444415,0.01447369,0.01988652,-0.07293302,0.043469448,0.12426544,0.011997116,-0.021612443,0.012783716,0.044091817,0.034164663,-0.05379804,-0.05068308,0.012276918,0.032229804,0.026016157,-0.051090825,-0.02843097,-0.012233348,-0.02187568,-0.010255581,0.07091546,-0.048615243,-0.031659544,0.042125147,-0.101625815,0.0625771,0.08382098,0.008944647,0.108518094,-0.041440237,0.015257649,-0.0135497,0.03280594,-0.008964016,0.0077318638,0.04506646,0.0095773125,0.060724284,0.096419096,0.007831181,0.0152376685,0.09397592,0.07084752,0.008463016,0.0075988555,-0.037691083,0.06428395,-0.022946876,0.04885402,-0.04825891,0.054102004,0.101672865,0.012057786,0.039643303,-0.04500026,-0.039373722,-0.10287057,0.05524383,0.014613132,-0.080241226,-0.04578716,-0.008564254,0.006317822,-0.01804736,-0.030574838,-0.055968333,-0.005918972,0.03520392,-0.021981578,0.021104828,-0.063459106,0.028721329,-0.046397213,-0.032900482,1.9423185e-33,-0.050131872,-0.07233176,0.006517437,-0.009770115,0.0012152584,0.03262746,-0.026354922,-0.17247894,-0.019856434,0.081106424,0.02197408,0.05406422,0.04717696,-0.04765909,0.060986374,0.03714663,-0.064488016,-0.05029234,0.0886715,-0.009229691,0.0075599453,0.08849569,0.027635824,0.04191214,0.039998353,0.05784655,-0.032710597,0.009904373,0.018160459,0.054377098,0.05682356,0.02135305,-0.09520718,-0.037526492,-0.050535947,-0.08163383,0.08369463,0.043726932,0.0040038014,-0.003337331,0.037788805,0.036244527,-0.0042140274,0.14379315,-0.04684554,0.013663093,0.07926568,-0.020665063,0.030223744,0.05057593,-0.018513858,-0.086178035,-0.07583318,-0.03216732,-0.025714448,-0.06935636,0.028185032,0.059341352,-0.026195612,0.029161802,0.062405966,-0.021127302,0.07086086,-0.05336216,0.03923583,-0.052638926,-0.013585774,0.13479158,0.02843234,0.049202528,0.04161349,0.09417971,0.10558358,-0.06084688,-0.021666436,0.0059049153,-0.015171688,0.037239682,0.025117068,-0.019119684,-0.02553583,0.00070164853,0.0087346425,-0.04532933,0.030254306,-0.12709531,0.025486352,0.0056386716,-0.031363763,-0.0065417024,-0.044666093,0.03406188,0.051363,0.020588111,-0.08177112,-1.4773268e-08,-0.07523463,0.0011237485,0.016023146,-0.042561483,0.008760203,0.0085942,0.04015263,-0.031745512,-0.028120264,0.0130028855,0.03657854,0.03740095,0.09984513,-0.0011536697,0.05729272,-0.034588095,0.019776205,0.089067765,-0.07187036,-0.05924737,-0.080893286,-0.041323666,-0.033375647,0.0396294,0.011878222,-0.019456035,-0.0046423576,-0.029919215,0.07149047,0.021430269,-0.058517,0.0038932343,-0.027600368,-0.023435276,-0.02749246,0.027492367,0.0054548956,0.009215663,-0.013423877,-0.050297283,-0.012353761,0.062447686,-0.02013099,-0.022789508,-0.031834174,0.0075663156,-0.07518661,-0.059446964,-0.055041708,-0.0062214406,0.053594608,-0.006450981,0.023155697,-0.008346988,0.014302364,0.09564623,-0.009267767,0.011880439,0.09211617,-0.026712509,0.060796443,-0.03838758,0.041849215,-0.062430806 +1.14.12.3,"A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin. Requires Fe2+.",384,1.0,-0.07866874,-0.0622578,-0.1624548,0.050986715,0.10434601,0.0016418596,-0.035100285,0.051637463,-0.002307643,-0.08545591,-0.0045495657,0.019689707,-0.02398861,-0.036530863,-0.0766561,-0.02043525,-0.054121874,0.0037634445,-0.01709128,-0.0044392897,-0.014533728,0.0018169931,0.0028592006,-0.0195393,-0.048201833,0.033752453,0.005281681,-0.04171029,-0.058005758,-0.0321913,0.03845298,0.017107662,0.09420798,-0.027171401,-0.05159024,0.09524546,0.05452472,-0.02728865,-0.09465101,-0.013554074,-0.0290214,-0.018031117,0.045526087,0.0024250515,0.027455598,0.0039211777,-0.014653523,0.023695543,-0.04430902,0.0065355906,-0.07471001,-0.030403385,-0.09620451,0.117008,0.05453009,-0.010571145,-0.005102344,-0.10445767,-0.069195956,-0.044496164,-0.0022274822,-0.06811772,-0.018837912,0.012404339,0.10253359,0.0184064,-0.033330493,-0.01805902,-0.022288624,-0.021470353,0.0067388224,-0.01840443,-0.10095022,0.04689401,-0.005768908,0.020358618,-0.0048796404,-0.033396125,0.10447789,0.00025892435,-0.0016177433,0.04240698,0.028269641,0.083560444,0.05943028,-0.017145421,-0.06161649,-0.044379912,-0.06403839,0.048544854,-0.031815913,-0.007725783,0.008962499,0.0052884603,-0.026094496,0.052262228,0.06727034,-0.023439948,-0.026535118,0.024557857,-0.07745716,0.02673259,0.025912672,-0.035584707,-0.07295676,-0.09204773,-0.0784253,0.15885136,-0.018303754,-0.030621406,0.013062535,-0.055313315,0.008445805,-0.03569987,0.03934976,0.011269143,0.020229835,-0.036643192,0.0034802968,-0.004909967,0.06174013,0.11088502,0.025503498,0.052049484,0.06585375,-0.040135756,-0.14041987,1.0031526e-34,0.061487284,0.03591773,0.026031144,0.056391988,-0.040227108,0.02685061,-0.093297526,-0.025245247,0.026056595,0.032451097,-0.062394768,0.005244025,0.025417855,-0.026053984,0.07253613,-0.058769945,-0.027857352,-0.047265932,0.13572076,-0.09745499,0.064015,0.13090195,0.013307911,-0.039761562,0.025467152,0.034910657,-0.06667464,0.004669978,-0.014132113,0.007725721,0.061150976,-0.03559023,-0.062487468,0.041926607,0.0035529817,0.013644556,-0.043173257,-0.10039544,-0.05792631,0.008087675,0.0059587546,-0.013267328,-0.021350978,-0.018634353,0.088702515,-0.09208253,-0.061145864,0.074840195,0.020468371,0.12268148,-0.008613292,-0.0005677223,0.08829525,0.029976089,-0.0917452,-0.012983283,-0.06210935,0.02680723,-0.008058923,0.06742074,0.029629234,0.033060096,0.016542116,0.073682204,-0.038111024,0.000729241,-0.051780615,-0.05953796,0.042784277,0.11880393,0.02335736,0.0045087044,0.10040952,0.055398196,0.07168114,-0.06495697,-0.011109168,-0.06627934,-0.040577248,0.018622665,-0.079394065,-0.073063634,-0.05023969,-0.00023286161,-0.046859737,0.013194033,-0.057426557,-0.029409768,-0.028046325,-0.044216428,-0.01867994,-0.010128035,-0.02184991,0.02550405,0.07547485,-1.5086702e-33,0.020409016,-0.10818558,0.018416267,-0.00049692934,0.052370813,0.037954476,0.011687614,-0.05350674,-0.011978035,0.0087241,0.034471177,-0.029720519,0.0033425277,-0.038712908,0.03784765,0.039972696,-0.04344501,-0.030115066,0.088190645,0.048025835,-0.049783267,0.069690205,0.009525628,0.04783013,0.05505902,0.021070588,-0.04193555,-0.027206771,0.068730496,0.047014456,-0.035427563,-0.0021837275,-0.03164377,-0.06692175,-0.084779516,0.049961977,0.013897797,0.0021541193,-0.046741914,0.025683166,-0.003934821,-0.004150557,-0.0043851375,0.11314556,0.07417517,0.04165949,-0.045933727,0.06900799,0.040119693,-0.023069296,0.019598518,-0.019273559,-0.019488389,0.022905888,0.05439688,0.007418305,0.037374385,0.05591654,-0.007826426,0.059512544,0.0032848075,-0.13206711,0.0045823934,0.019464573,0.0642079,0.010593581,0.0047048237,0.048313133,0.020251285,0.07347412,0.10263847,0.038153842,0.021300416,0.030350832,0.03558732,-0.07127199,-0.035362735,0.07597701,0.0007835373,0.027253116,-0.0042104274,-0.020282676,0.045711543,0.016312217,-0.00867581,-0.130623,0.0068701156,0.018740047,-0.010591557,-0.009476074,-0.049699623,0.030572461,-0.010023132,-0.0017887846,-0.008609659,-2.750393e-08,0.015724115,-0.057348657,0.018829653,-0.042057954,0.06601555,0.019938493,0.008099821,-0.030314645,-0.058667824,0.004254053,-0.020621791,0.14346245,0.033802163,-0.054086275,0.067390986,-0.017870417,0.021883478,0.06041146,-0.037594244,-0.0103334775,0.013323949,0.026058136,-0.096851304,0.027010614,-0.0067159883,-0.051046237,-0.0067676525,-0.0371884,0.045182902,0.00755862,0.023828654,0.04259093,0.03255053,-0.024576103,-0.116424374,0.05011627,-0.015673593,-0.06282489,-0.027691899,-0.026953483,-0.07630665,0.07788975,-0.029182704,-0.010833761,0.017692458,-0.001137286,-0.007419617,-0.017765565,-0.049936272,-0.017638538,0.019037759,-0.005622187,0.052751333,-0.04186376,-0.058842096,0.045028165,0.06154756,-0.06023564,0.039102573,-0.030027905,0.045817707,0.050273538,0.1093562,0.0063855657 +1.14.12.4,A flavoprotein 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flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.14.12.7,"A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+.",384,1.0,-0.054535877,-0.038554873,-0.17370585,0.09672541,0.06575002,0.0023082984,-0.022585217,0.037585776,0.0017186359,-0.12444355,0.010583133,0.011134295,-0.025600635,0.0053385175,-0.08901781,-0.022055,-0.059726898,-0.0067986967,-0.015437002,0.015313092,-0.045027055,-0.0029785256,0.0049604406,-0.015520431,-0.09159161,0.018116942,0.0016552529,-0.008633368,-0.06108763,-0.04595623,0.035153355,0.015678735,0.0993521,-0.0061770417,-0.037153818,0.080886304,0.033121493,-0.041202538,-0.08230346,-0.017748768,-0.041421898,-0.025589874,0.02889421,-0.03706705,0.0056062774,-0.028868878,-0.013442699,-0.004580548,-0.02400954,0.026696606,-0.105086535,-0.028362542,-0.077787735,0.14583525,0.09775786,-0.021939933,-0.027591776,-0.09013186,-0.102330685,-0.0036073136,-0.007200026,-0.019258332,-0.025608018,-0.005463294,0.1113667,0.027781695,-0.02308241,-0.014430106,-0.037584346,-0.0029494176,0.016638555,-0.025914313,-0.09983968,0.03359036,-0.0131385885,0.049383193,0.018980885,0.0022933928,0.09974232,0.016638236,-0.033604443,0.0385829,-0.00383802,0.100674085,0.039035387,-0.040060233,-0.10022567,-0.016554836,-0.043030996,0.07396157,-0.051947422,0.035457544,0.021123132,-0.028850043,0.027828803,0.02852924,0.040887557,0.012740682,-0.028866477,0.05407492,-0.059679158,0.014841891,-0.003976924,-0.058212604,-0.06972795,-0.049526896,-0.045737505,0.09879425,0.04357704,-0.042783447,0.022905895,-0.045116503,0.035967916,-0.047849443,0.019053342,0.027874468,0.014747936,-0.026599713,0.0110271415,0.038013857,0.06539091,0.08938784,0.009591002,0.06074822,0.050768796,-0.027368601,-0.15010607,-1.1585108e-35,0.053177048,0.056725778,0.068211764,0.04906271,-0.041051302,0.013826227,-0.03736238,-0.03696048,0.013963541,0.018219532,-0.10709377,0.019980965,0.031154182,-0.057077482,0.052443013,-0.08098545,-0.023110298,-0.0518135,0.10840085,-0.041846942,0.09169416,0.077238,0.017765312,-0.05753712,0.02230357,0.060539182,-0.054016598,-0.02207529,-0.011731087,0.007899832,0.050627828,-0.040600263,-0.055896163,0.048802406,0.05083264,-0.042732738,-0.03727532,-0.065136716,-0.05973653,0.028964676,0.000461431,-0.010143753,-0.041458696,-0.034827597,0.108146206,-0.057327766,-0.07651172,0.07579866,0.021023458,0.11671163,0.009236708,-0.0034395102,0.0654254,-0.006202625,-0.055950474,-0.005591133,-0.038727976,0.061360866,-0.0091087,0.081814855,-0.0015846649,0.016660366,0.008617756,0.043368362,0.011558605,0.016719816,-0.056912538,-0.043534745,0.044236876,0.05368583,0.040711664,0.030250952,0.087439805,0.05237226,0.054836776,-0.047773626,-0.041103132,-0.052599985,-0.015842916,0.019125631,-0.04535489,-0.07422508,-0.058889873,-0.004704184,-0.06713098,0.013205136,-0.041304313,-0.0069000707,-0.054265648,-0.045373335,0.002109782,-0.0027119657,-0.031943493,-0.03883996,0.05061354,-1.3127708e-33,-0.0005659927,-0.10416676,-0.04145978,-0.024495246,0.025759954,0.048686516,-0.016831392,-0.07120222,-0.03635117,0.04411967,0.04066445,-0.04966978,0.023521533,-0.06521509,0.0076812566,0.051437613,-0.03993894,0.0054322192,0.08006461,0.044779994,-0.051161107,0.07132008,-0.008291056,0.06871612,0.039122455,0.03093422,-0.0398846,0.029927628,0.092232876,0.06324425,-0.05369463,0.00012946199,-0.023763383,-0.098982,0.00713106,0.060406096,0.014283769,-0.011263785,-0.01870179,0.012672261,0.0025558718,0.0049387948,0.03029799,0.124717444,0.06465698,0.065397486,-0.06594903,0.066395275,0.03653379,0.013439605,0.0076387627,-0.02504444,-0.05283689,0.017316574,0.02226478,0.002094198,0.033892743,0.051726665,-0.0065474086,0.05188734,-0.0060710143,-0.13679317,-0.00028885397,0.015758533,0.027883416,0.024336789,0.009718598,0.048143208,0.046725534,0.04676521,0.08995822,0.008836936,0.055834413,-0.0043032784,0.008283413,-0.032782104,-0.0050141932,0.06884385,-0.01892834,0.0074178996,-0.013211929,-0.033152577,0.0433997,-0.060433872,0.047354627,-0.106838964,0.0077939145,0.0036296481,-0.0025067888,-0.0070524635,-0.004470293,0.034870032,-0.044687405,-0.022385605,-0.04554449,-2.7698766e-08,0.030057117,-0.08715719,0.024350941,-0.019548904,0.06843737,0.015725136,0.0589147,-0.033637755,-0.062895186,0.045860562,-0.0026735913,0.12041251,0.017553281,-0.052858286,0.055873536,-0.024987368,0.039652467,0.08549837,-0.038698185,-0.015368603,0.018180095,0.016160982,-0.11036859,0.017112935,-0.015569563,-0.0767488,-0.019819332,-0.04188881,0.07325025,-0.015233903,0.046552557,0.071732014,0.022254579,-0.031821333,-0.16110575,0.0017726595,-0.012001197,-0.025381459,-0.03835952,-0.053120364,-0.097491115,0.082098365,-0.040159255,-0.015317455,0.008614631,-0.013240674,0.004316357,-0.0240855,-0.00023405747,-0.010893676,0.02711864,0.013965609,0.036196876,-0.031943418,-0.04776943,0.06414016,0.099514134,-0.0018625511,0.0475463,-0.035111967,0.0004594525,0.037507646,0.11704657,0.0069311303 +1.14.12.8,"A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+.",384,1.0,-0.054535877,-0.038554873,-0.17370585,0.09672541,0.06575002,0.0023082984,-0.022585217,0.037585776,0.0017186359,-0.12444355,0.010583133,0.011134295,-0.025600635,0.0053385175,-0.08901781,-0.022055,-0.059726898,-0.0067986967,-0.015437002,0.015313092,-0.045027055,-0.0029785256,0.0049604406,-0.015520431,-0.09159161,0.018116942,0.0016552529,-0.008633368,-0.06108763,-0.04595623,0.035153355,0.015678735,0.0993521,-0.0061770417,-0.037153818,0.080886304,0.033121493,-0.041202538,-0.08230346,-0.017748768,-0.041421898,-0.025589874,0.02889421,-0.03706705,0.0056062774,-0.028868878,-0.013442699,-0.004580548,-0.02400954,0.026696606,-0.105086535,-0.028362542,-0.077787735,0.14583525,0.09775786,-0.021939933,-0.027591776,-0.09013186,-0.102330685,-0.0036073136,-0.007200026,-0.019258332,-0.025608018,-0.005463294,0.1113667,0.027781695,-0.02308241,-0.014430106,-0.037584346,-0.0029494176,0.016638555,-0.025914313,-0.09983968,0.03359036,-0.0131385885,0.049383193,0.018980885,0.0022933928,0.09974232,0.016638236,-0.033604443,0.0385829,-0.00383802,0.100674085,0.039035387,-0.040060233,-0.10022567,-0.016554836,-0.043030996,0.07396157,-0.051947422,0.035457544,0.021123132,-0.028850043,0.027828803,0.02852924,0.040887557,0.012740682,-0.028866477,0.05407492,-0.059679158,0.014841891,-0.003976924,-0.058212604,-0.06972795,-0.049526896,-0.045737505,0.09879425,0.04357704,-0.042783447,0.022905895,-0.045116503,0.035967916,-0.047849443,0.019053342,0.027874468,0.014747936,-0.026599713,0.0110271415,0.038013857,0.06539091,0.08938784,0.009591002,0.06074822,0.050768796,-0.027368601,-0.15010607,-1.1585108e-35,0.053177048,0.056725778,0.068211764,0.04906271,-0.041051302,0.013826227,-0.03736238,-0.03696048,0.013963541,0.018219532,-0.10709377,0.019980965,0.031154182,-0.057077482,0.052443013,-0.08098545,-0.023110298,-0.0518135,0.10840085,-0.041846942,0.09169416,0.077238,0.017765312,-0.05753712,0.02230357,0.060539182,-0.054016598,-0.02207529,-0.011731087,0.007899832,0.050627828,-0.040600263,-0.055896163,0.048802406,0.05083264,-0.042732738,-0.03727532,-0.065136716,-0.05973653,0.028964676,0.000461431,-0.010143753,-0.041458696,-0.034827597,0.108146206,-0.057327766,-0.07651172,0.07579866,0.021023458,0.11671163,0.009236708,-0.0034395102,0.0654254,-0.006202625,-0.055950474,-0.005591133,-0.038727976,0.061360866,-0.0091087,0.081814855,-0.0015846649,0.016660366,0.008617756,0.043368362,0.011558605,0.016719816,-0.056912538,-0.043534745,0.044236876,0.05368583,0.040711664,0.030250952,0.087439805,0.05237226,0.054836776,-0.047773626,-0.041103132,-0.052599985,-0.015842916,0.019125631,-0.04535489,-0.07422508,-0.058889873,-0.004704184,-0.06713098,0.013205136,-0.041304313,-0.0069000707,-0.054265648,-0.045373335,0.002109782,-0.0027119657,-0.031943493,-0.03883996,0.05061354,-1.3127708e-33,-0.0005659927,-0.10416676,-0.04145978,-0.024495246,0.025759954,0.048686516,-0.016831392,-0.07120222,-0.03635117,0.04411967,0.04066445,-0.04966978,0.023521533,-0.06521509,0.0076812566,0.051437613,-0.03993894,0.0054322192,0.08006461,0.044779994,-0.051161107,0.07132008,-0.008291056,0.06871612,0.039122455,0.03093422,-0.0398846,0.029927628,0.092232876,0.06324425,-0.05369463,0.00012946199,-0.023763383,-0.098982,0.00713106,0.060406096,0.014283769,-0.011263785,-0.01870179,0.012672261,0.0025558718,0.0049387948,0.03029799,0.124717444,0.06465698,0.065397486,-0.06594903,0.066395275,0.03653379,0.013439605,0.0076387627,-0.02504444,-0.05283689,0.017316574,0.02226478,0.002094198,0.033892743,0.051726665,-0.0065474086,0.05188734,-0.0060710143,-0.13679317,-0.00028885397,0.015758533,0.027883416,0.024336789,0.009718598,0.048143208,0.046725534,0.04676521,0.08995822,0.008836936,0.055834413,-0.0043032784,0.008283413,-0.032782104,-0.0050141932,0.06884385,-0.01892834,0.0074178996,-0.013211929,-0.033152577,0.0433997,-0.060433872,0.047354627,-0.106838964,0.0077939145,0.0036296481,-0.0025067888,-0.0070524635,-0.004470293,0.034870032,-0.044687405,-0.022385605,-0.04554449,-2.7698766e-08,0.030057117,-0.08715719,0.024350941,-0.019548904,0.06843737,0.015725136,0.0589147,-0.033637755,-0.062895186,0.045860562,-0.0026735913,0.12041251,0.017553281,-0.052858286,0.055873536,-0.024987368,0.039652467,0.08549837,-0.038698185,-0.015368603,0.018180095,0.016160982,-0.11036859,0.017112935,-0.015569563,-0.0767488,-0.019819332,-0.04188881,0.07325025,-0.015233903,0.046552557,0.071732014,0.022254579,-0.031821333,-0.16110575,0.0017726595,-0.012001197,-0.025381459,-0.03835952,-0.053120364,-0.097491115,0.082098365,-0.040159255,-0.015317455,0.008614631,-0.013240674,0.004316357,-0.0240855,-0.00023405747,-0.010893676,0.02711864,0.013965609,0.036196876,-0.031943418,-0.04776943,0.06414016,0.099514134,-0.0018625511,0.0475463,-0.035111967,0.0004594525,0.037507646,0.11704657,0.0069311303 +1.14.12.9,"A system, containing a reductase and an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+. Also acts on 4-bromophenyl acetate.",384,0.99999994,-0.043212257,-0.025752924,-0.13092794,0.05298434,0.03771445,0.024879087,-0.02812411,0.005882955,-0.0031116419,-0.09246852,0.025569042,-0.051467337,-0.0014511136,0.016490271,-0.08781618,0.0063507636,-0.079667196,-0.0007963129,-0.011955474,-0.005755959,-0.027492413,-0.013677852,0.0072041387,0.034029897,-0.03882311,0.019685155,-2.3497734e-05,0.0011400831,-0.043452073,-0.07758692,-0.023182152,-0.007942141,0.096006386,-0.029315226,0.001024119,0.084635615,0.023467252,-0.0161639,-0.026677435,0.0024883712,-0.0439153,-0.039277148,0.026079973,-0.016296128,-0.0403769,-0.039859604,0.0040720343,-0.0060705757,-0.03051337,0.0120782275,-0.10357705,-0.05947345,-0.07509963,0.11371175,0.07415703,-0.044770457,-0.05588581,-0.09159299,-0.06588478,-0.07059613,0.02790633,-0.06510624,-0.03561934,0.017126,0.045310613,0.04682135,-0.0077182944,-0.014843729,-0.07301498,-0.014082364,0.037963845,-0.027380293,-0.08666889,0.040092606,-0.026903085,-0.017360002,0.009003964,-0.07717653,0.09789538,0.025041949,-0.039988946,0.03859481,-0.03977628,0.09005547,0.059334066,-0.0049136616,-0.0599748,-0.052733876,-0.04575635,0.028173368,-0.060214255,-0.00096687255,0.025191411,-0.040137958,0.03361954,0.031908277,0.079593875,-0.0389528,0.017595014,0.04721243,-0.052489597,0.035476513,0.0019850347,-0.045406096,-0.04045805,-0.020602517,-0.042509865,0.10764141,0.027050726,-0.022816373,-0.0033461,-0.079189375,0.03604731,-0.0015799456,0.00073796435,0.051978577,0.053609785,-0.02955416,-0.011989088,0.031502485,0.09134285,0.06281163,0.05408881,0.016851671,-0.003148404,0.0017792501,-0.103563465,1.9198767e-33,0.10147255,0.049286462,0.05729312,0.08255,-0.0064831926,0.017120939,-0.1011876,-0.037768282,0.018709933,0.01282931,-0.076024614,-0.0022322435,0.033174474,-0.022755194,0.07533264,-0.091207765,-0.044452578,-0.027613586,0.086509936,-0.049982246,0.036528647,0.12590893,-0.031466503,-0.017469183,0.028094765,0.025857797,0.001938076,-0.044464108,0.0029398683,-0.00086725753,0.08901355,0.0043101646,-0.08544313,0.018012263,0.042511605,-0.03625881,-0.06426525,-0.06571,-0.030301185,0.02536284,-0.015037508,-0.0046780105,-0.04588862,-0.08265876,0.11251529,-0.10561737,-0.041679263,0.07615321,0.022800907,0.11852863,0.0018881563,0.0052402467,0.0927882,-0.05024605,-0.04295881,-0.016092002,-0.038708095,0.061006423,0.010727051,0.09469663,0.013273011,0.0149521325,0.0140188355,0.04557111,0.0059407386,0.012377667,-0.093561135,-0.08734979,0.022578152,0.060537435,-0.0035797507,0.010781182,0.061840344,0.028690979,0.06700239,-0.06458578,-0.05745632,-0.06510544,-0.014492628,-0.0005777519,-0.03920147,-0.0754036,-0.028470203,0.012346161,-0.04126325,-0.008644806,-0.051440317,-0.03442612,-0.0356184,0.0076904204,-0.03304766,0.0006704103,-0.019192224,-0.019816058,0.06313911,-3.3737022e-33,0.05269878,-0.10734073,0.0130263595,-0.019002572,0.020669946,0.09038504,-0.015532209,-0.039876636,-0.03164834,0.027553532,0.0689162,0.009186789,0.053707827,-0.04362302,0.03715025,0.08727257,-0.029733889,-0.038570985,0.077178024,0.051176727,0.0074485284,0.075264424,-0.026340753,0.07015334,0.07249931,0.07307739,-0.0967184,0.0153142195,0.10145317,0.044388887,-0.08696218,-0.04671576,0.0041485964,-0.06939973,-0.06501921,0.0749404,0.037571102,-0.027400184,-0.04122482,0.026999388,0.015894944,-0.04070052,0.052983876,0.15004525,0.08437518,0.004496085,-0.040738348,0.03803929,-0.0115970345,-0.01718996,-0.010952238,-0.035197474,-0.060147572,-0.019746635,0.043698486,0.010108228,0.023089953,0.017011365,0.0019608121,0.04333391,-0.0039308486,-0.10353887,0.014153783,0.07659993,0.02232465,0.024209755,-0.05198834,0.022949632,0.04337576,0.029801043,0.085661404,0.013606696,0.056458775,-0.020603621,0.060651656,-0.04982152,-0.039440237,-0.004415479,-0.01696431,-0.0059343576,-0.06373523,-0.007064568,0.041094124,-0.05715083,-0.00087750156,-0.12584418,-0.01006785,-0.02903587,-0.004803697,-0.0077684685,-0.026854962,0.033910763,-0.022124058,0.02112967,-0.007797813,-2.794914e-08,0.04771045,-0.04390487,0.061690174,-0.05097419,0.032534793,-0.009386887,0.0884379,-0.03644741,0.008405913,-0.004299817,0.016242024,0.12401841,0.065712966,-0.00018147493,0.07327088,-0.017422099,-0.028514866,0.06185497,-0.051148634,-0.024325062,0.014339072,-0.0036545054,-0.08252017,0.060644284,-0.023914667,-0.073902555,-0.0126510365,0.00023922343,0.03553491,0.008355545,0.04976032,0.06673384,0.012334642,-0.060790915,-0.11961469,0.038340624,-0.048835855,-0.03952195,-0.020776782,-0.032298718,-0.047140494,0.065645486,-0.09678461,0.002821827,0.05581124,-0.0006922934,-0.02547877,-0.04348097,-0.0055211084,0.0028775532,0.03320595,0.0017047364,0.0725145,-0.010828169,-0.043822788,0.08969239,0.10523849,-0.018403478,0.071242854,-0.048691753,0.036206175,0.034801345,0.10889943,-0.0006128015 +1.14.12.10,"A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), and an iron-sulfur oxygenase. Requires Fe2+.",384,1.0,-0.06929313,-0.06368698,-0.16564494,0.06237618,0.09638248,0.00086392945,-0.02944058,0.04830165,-0.0009798935,-0.08729409,0.0031674718,0.015543306,-0.020655382,-0.035874616,-0.07575342,-0.016007345,-0.053028498,0.005293971,-0.0139741525,-0.011738582,-0.0026540936,-0.006603378,0.0015659267,-0.010516687,-0.055173803,0.04312182,0.008099219,-0.045403667,-0.058401912,-0.047870517,0.03527711,-0.002925163,0.1013192,-0.033817198,-0.051656727,0.09962684,0.04238506,-0.039774437,-0.09999058,-0.013798207,-0.019442946,-0.021805989,0.028506508,0.012440045,0.028121786,-0.0020634455,-0.013590197,0.033196263,-0.040227972,0.007890014,-0.086645246,-0.028572693,-0.10719199,0.11704047,0.055463534,-0.010217148,-0.01805698,-0.09391503,-0.07166469,-0.043216217,0.00090173434,-0.07053523,-0.023977773,0.009756568,0.09729362,0.013968335,-0.022079488,-0.013438518,-0.020965843,-0.018692458,-0.0017078066,-0.012820297,-0.1093527,0.055930596,-0.011210874,0.01408649,0.011135612,-0.025169367,0.1103875,0.0042911917,-0.0075581744,0.041888434,0.016567808,0.08830563,0.05934767,-0.010395294,-0.066940404,-0.03938847,-0.05628394,0.04307252,-0.035124045,-0.011526823,0.017478876,0.003184848,-0.016136635,0.053962197,0.06502261,-0.008083108,-0.021794315,0.022925537,-0.06746969,0.01449533,0.023244334,-0.030834055,-0.078580245,-0.08530258,-0.07752634,0.15134938,-0.011380802,-0.024659285,0.015743624,-0.055302482,0.0044210018,-0.044079732,0.041911323,0.020150654,0.034083713,-0.03167696,0.00034290072,0.0012773355,0.06359848,0.11270235,0.02041046,0.04247683,0.049221992,-0.03243438,-0.14302158,-5.6704695e-34,0.055121228,0.052430786,0.048318688,0.060734455,-0.056024663,0.022935392,-0.092672676,-0.025452308,0.0143924095,0.033174373,-0.060553037,0.006121894,0.0211042,-0.009813475,0.07221438,-0.060330175,-0.020854365,-0.043541085,0.13772741,-0.092720546,0.04119647,0.13787565,0.012773495,-0.047390785,0.03178037,0.024536299,-0.05037086,-0.013242036,-0.021713484,0.006392845,0.06268724,-0.034176275,-0.06394263,0.042968854,0.014334598,-0.0010786415,-0.04343575,-0.10336976,-0.046197366,-0.0026881937,0.0026929236,-0.0056185885,-0.025920987,-0.015965044,0.08518435,-0.09005631,-0.05627836,0.079049155,0.02510181,0.11316476,-0.01763103,0.0029143738,0.09631949,0.031595998,-0.097624116,-0.011395243,-0.052986614,0.031708248,-0.00906654,0.0715093,0.027454345,0.040449437,0.0141226025,0.06716093,-0.03380104,0.0038839492,-0.071361385,-0.056403536,0.05112137,0.10963745,0.019658582,0.0069375713,0.0992746,0.056533284,0.058967978,-0.060195096,-0.022584848,-0.06078513,-0.044574335,0.027700704,-0.08759366,-0.08072895,-0.03967642,0.008316547,-0.0606133,0.017273193,-0.05407444,-0.029511377,-0.025100457,-0.052113116,-0.01975642,-0.0048670517,-0.023528295,0.020636579,0.07328747,-1.094099e-33,0.026635105,-0.11224674,0.004640215,-0.0010291692,0.04951261,0.03111537,0.0026813552,-0.07418402,-0.017479468,0.01401777,0.030405048,-0.025332186,0.012108883,-0.05402392,0.032051068,0.047408454,-0.03470144,-0.010549329,0.08385916,0.037746307,-0.04345876,0.07781362,0.008331823,0.046119418,0.047798246,0.026890349,-0.044012547,-0.025666958,0.06691248,0.046325736,-0.035534933,-0.0048217853,-0.01974989,-0.07654905,-0.07693049,0.03588969,0.017801527,-0.00976959,-0.044823375,0.027175488,0.0014862397,-0.0039198743,0.018301658,0.11898855,0.07808435,0.045014504,-0.033710238,0.07851488,0.023622153,-0.020271458,0.024334248,-0.024072003,-0.031457447,0.035278004,0.05401726,0.0013152881,0.031044506,0.0531566,-0.0021872146,0.05271441,-0.008775836,-0.13427396,0.003797689,0.009626428,0.060097095,0.0077169407,0.006197247,0.045616645,0.019149937,0.06378674,0.09418496,0.044576924,0.015258121,0.015183481,0.025971247,-0.06760737,-0.047946002,0.062199693,-0.0037635101,0.021776238,-0.012979473,-0.03281393,0.054343186,-0.00042685666,0.013421477,-0.13329807,0.005938489,0.0090666,-0.012768302,-0.005734582,-0.050236825,0.0157284,-0.0253566,0.016124576,-0.016781667,-2.6668108e-08,0.02147952,-0.055406056,0.015764132,-0.037804674,0.06132471,0.025401738,0.015049667,-0.017432492,-0.052580014,0.023685975,-0.019143982,0.13651432,0.044622365,-0.04941665,0.07070853,-0.014067075,0.023277357,0.073781684,-0.036144927,-0.011277363,0.027086806,0.014465533,-0.09113664,0.028540375,0.005297121,-0.05781425,-0.0011545342,-0.04191084,0.057743203,0.006992039,0.03413396,0.040274326,0.03215836,-0.022790322,-0.11129293,0.04886375,-0.017592935,-0.06559255,-0.026830204,-0.020700997,-0.07785496,0.08194908,-0.041770846,0.0047064032,0.028663132,-0.0018426981,-0.017366616,-0.014875871,-0.046370026,-0.017148102,0.026159192,-0.00034421316,0.048820924,-0.04361308,-0.061068434,0.042282887,0.06320705,-0.051694423,0.049011506,-0.03441644,0.0585013,0.04201696,0.11357626,0.0048780777 +1.14.12.11,"A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase, and a ferredoxin. Some other aromatic compounds, including ethylbenzene, 4-xylene and some halogenated toluenes, are converted into the corresponding cis-dihydrodiols.",384,0.99999994,-0.09023623,-0.06973343,-0.14581215,0.0047482597,0.10987157,-0.007135123,0.00099463,0.08099432,0.03468889,-0.07844733,-0.0036298025,0.031318717,-0.021409377,-0.059681255,-0.07959454,-0.01802356,-0.058556676,0.030193344,-0.036695994,0.0023130975,-0.038813174,0.009856811,-0.012120367,0.0075679645,-0.028056754,0.017204732,0.0036919767,-0.022431724,-0.051901337,0.004340611,0.07330453,0.049819674,0.040086824,-0.014972389,-0.028452775,0.109776184,0.10358406,-0.04164144,-0.07068426,-0.0011424382,-0.0031411138,-0.019504044,0.031036064,0.0013002513,0.019418059,-0.013368533,-0.05327685,0.0153886285,-0.06560079,-0.05965551,-0.042159215,-0.037927162,-0.09521827,0.12751654,0.030949362,-0.002676337,0.0064136675,-0.0816269,-0.0756513,-0.011040561,0.017206188,-0.05326343,-0.02553651,0.0017780658,0.057474505,0.036037974,-0.033839382,-0.034519214,0.011307897,-0.038167488,-0.043183748,-0.02213251,-0.085551895,0.041389707,0.013147434,-0.0092739975,-0.042959552,-0.030192032,0.05717958,-0.06576029,0.06362428,0.08967047,0.03752858,0.025602864,0.067435555,-0.02696145,-0.05883496,-0.021902328,-0.0304268,0.03652701,-0.054840736,-0.012536399,-0.007668878,-0.008369156,-0.08760618,0.055100374,0.0871629,-0.029724987,0.03666399,0.051574063,-0.021727463,0.033041008,-0.014129838,-0.083158866,-0.12658976,-0.08014993,-0.0594929,0.11986264,-0.05979097,-0.036490265,-0.05031634,-0.073984504,0.0050735483,-0.052400507,-0.008147756,-0.018886264,-0.0057647466,-0.039372966,0.022465432,-0.03490155,0.006578599,0.09868976,0.048412625,0.062839195,0.07718184,-0.030362325,-0.13753001,9.749455e-34,0.04411654,0.048275206,0.007496039,0.06334822,-0.01463045,0.038002808,-0.07810201,0.005174058,0.025760753,0.001770716,-0.061368648,0.031486128,-0.01053691,-0.065994814,0.07045896,-0.07321956,-0.049582694,0.030808102,0.13437153,-0.1128608,0.0640557,0.12110925,-0.0057857195,0.007969662,0.050666705,0.030548608,-0.0987268,0.02911553,-0.012001348,0.0059979125,0.008301417,-0.010843345,-0.034193393,0.024420854,-0.020474892,0.06743161,-0.05977594,-0.08150431,-0.017472554,0.027538318,0.016549876,-0.057827268,-0.0131121725,0.024085904,0.06924063,-0.029133312,-0.09085222,0.04419485,0.005266098,0.052429046,-0.024650702,-0.015549775,0.07804704,0.008629813,-0.110897824,0.008567498,-0.06439514,0.017048996,0.0033494292,0.03360649,0.017446453,0.07456552,-0.047974344,0.029460596,-0.027539212,-0.022656947,-0.019247897,-0.052624065,0.042417977,0.114640094,-0.011743597,-0.008593835,0.09936764,0.04396805,0.09496052,-0.022470122,-0.06814129,-0.0813804,-0.052738275,0.017323822,-0.075894795,-0.03425512,-0.048402373,-0.036385763,-0.05026366,0.011008021,-0.03464651,-0.019003095,-0.0011491106,-0.027583366,-0.0052864132,-0.065091155,0.013849204,0.0031285058,0.04905468,-1.8324429e-33,0.03838575,-0.08305702,-0.0037709447,0.0072052763,0.07338432,0.04003671,0.046988346,-0.031917915,-6.144407e-05,-0.00026966358,0.063844696,-0.03849792,-0.008507767,-0.036981806,0.019087575,-0.0030853918,-0.014001741,-0.023117928,0.07636605,0.06199761,-0.045276944,0.06056156,0.028911708,0.06603352,0.019378966,0.019513609,0.025100786,-0.013673032,0.088422254,0.052662976,0.0056662466,-0.025004668,-0.02335435,-0.021888027,-0.095630005,0.05676576,0.0025215112,0.0092223175,-0.089599274,0.045712676,-0.035420503,-0.007186717,-0.010417186,0.08363942,0.05390021,0.056579955,-0.08970602,0.054353625,0.04857655,-0.047650866,0.034813423,0.024488494,-0.026670927,0.022731252,0.05922616,0.006637642,0.02934859,0.029433355,-0.020073114,0.04965479,-0.031091267,-0.13144948,-0.0001229587,0.035751265,0.06632903,0.0065983087,-0.0058628772,0.012006738,0.03630976,0.06548503,0.12767816,-0.0023249597,-0.0051641427,0.05152025,0.011356873,-0.10520572,0.017762784,0.03376401,-0.02402758,0.026617665,-0.0179803,-0.055727743,0.048540402,0.023538012,-0.044954244,-0.14644264,-0.0038966145,0.058917806,-0.0011091898,-0.021810701,-0.002089208,0.08332119,-0.010646087,0.029077955,0.07258168,-3.716021e-08,0.010484227,-0.03686149,0.02031337,-0.011072531,0.06938952,-0.03812298,0.013983469,-0.019755572,-0.027313778,-0.023340954,-0.032405924,0.1022331,0.052020557,-0.065588586,0.090705216,0.027760882,0.026063783,0.07413427,-0.009985927,0.013639484,0.022079613,0.057138484,-0.10972953,-0.011842221,0.004442651,-0.04896878,-0.010929523,-0.02790441,0.046326067,0.060476888,0.046588276,0.034007613,0.051100645,0.016246127,-0.05130213,0.039465606,-0.034505162,-0.032891374,-0.019899068,-0.025977094,-0.048999954,0.0627165,-0.07098731,0.027174188,0.0142615,-0.00017772483,0.007313052,0.030999921,-0.0031263183,0.027610866,0.007775666,0.046894208,0.054261092,-0.055416007,-0.04023032,0.018726956,0.032692898,-0.048949864,-0.0074035893,-0.036017638,0.026689595,0.025100842,0.13881983,0.023416955 +1.14.12.12,"This enzyme is a member of the ring-hydroxylating dioxygenase (RHD) family of bacterial enzymes that play a critical role in the degradation of aromatic compounds, such as polycyclic aromatic hydrocarbons [5]. This enzyme comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.3, ferredoxin---NAD+ reductase), an iron-sulfur oxygenase, and ferredoxin. Requires Fe2+.",384,1.0,-0.06048883,-0.018470477,-0.13519049,0.01568422,0.12399036,0.021700183,-0.05674502,0.034091152,-0.003398885,-0.13202854,-0.0734756,0.013005195,-0.025152335,-0.014217932,-0.10603096,0.048775636,-0.061380066,-0.0066706953,-0.021693584,-0.020704413,-0.043260876,0.039923962,-0.0049677626,-0.028533777,-0.033994842,0.03852801,0.08580141,-0.030479815,-0.10011036,-0.03145171,0.08798643,0.0066825035,0.05296,-0.032524638,-0.02380474,0.15649134,0.009754435,-0.03287617,0.013044765,0.02954046,-0.024049243,0.040610522,0.027637199,-0.064813465,0.013065064,-0.009577612,-0.06266764,0.03149897,0.050082512,-0.008398245,-0.051162884,-0.018605549,-0.0611083,0.11982823,0.09339268,-0.018950466,-0.035540402,-0.0741038,-0.09446115,-0.013689715,0.027157344,-0.038480096,0.0064474405,0.009716355,-0.023859879,-0.024326315,0.042730007,-0.076619886,0.0039362563,-0.082914665,-0.068374984,-0.0054422235,-0.05358274,-0.0029691553,-0.03905784,0.041056752,-0.008313755,-0.04058401,0.10060247,-0.027682198,0.010266654,-0.0018769618,0.05803098,0.07182964,0.062288735,-0.00023054203,-0.04962267,-0.05652574,-0.013065152,0.06987942,0.015465497,0.026255554,0.0036259224,-0.046849802,-0.053177167,0.011174644,0.029202087,0.018331962,-0.027574262,0.00076937035,-0.06758544,0.033151392,0.0016376553,-0.11448062,-0.11795953,-0.04656043,-0.012786343,0.14770654,-0.0014395592,-0.049755707,0.001984315,-0.009487091,0.04402288,-0.03927327,0.0016246461,0.08124051,0.031091053,-0.052238867,-0.08662709,0.021218332,-0.007992812,0.032944273,0.032020606,0.022014156,0.0002147207,-0.06583327,-0.11157845,1.174947e-33,0.037033975,0.032997612,-0.029997505,0.002604537,0.00603133,0.026874008,-0.09720674,0.0044508963,-0.032472204,-0.017906293,-0.024360511,-0.026052853,0.033103343,-0.09037786,0.00071723334,-0.04863896,-0.022064675,-0.0016280223,0.06026175,-0.0446045,0.06223371,0.067623965,-0.0091108475,-0.009724962,0.01574033,0.053520676,0.0071953596,0.0190072,-0.035566214,0.014853258,0.02125436,-0.057565037,-0.12569702,0.013078715,0.016982745,-0.0021603915,-0.07949558,-0.028727958,-0.06466102,0.034022804,0.0042845993,-0.0016118996,-0.0118726855,-0.048843488,0.046012335,-0.05805659,-0.022661066,0.11896083,0.03101468,0.127713,0.0042009093,-0.020209214,0.10585569,0.0045913323,-0.116401754,0.01853255,-0.019564023,0.0046340236,0.04269015,0.04940622,0.013409627,0.045736082,-0.0757297,0.044034492,0.0056625945,-0.037713155,0.007935082,-0.012868242,0.022162829,0.118141055,0.027320905,0.014586481,0.10110281,0.030716494,0.03699319,-0.06216297,-0.04821238,-0.027172845,0.07857238,0.029742897,-0.0381135,-0.027042013,0.013688846,-0.027037432,-0.03690312,0.018431464,-0.030407531,-0.017633628,-0.02228096,0.028336974,0.054352738,-0.10910049,-0.032646727,-0.021146148,0.030460436,-2.2882533e-33,0.041637607,-0.106159806,-0.0024934828,-0.07149266,0.019513944,0.0505663,0.06767646,0.030423,-0.022611063,-0.012592198,0.07791338,-0.013073753,0.0107470965,0.004768627,0.070326954,0.043572314,-0.029933436,-0.002807114,0.04551274,-0.007957899,0.03034787,0.006202994,0.012768185,0.027196525,-0.014207257,0.02124484,-0.02272338,0.049491867,0.08915711,0.061133783,-0.04028087,0.04352562,-0.042913157,-0.016034633,-0.013163559,0.08174264,-0.061465506,0.014793909,0.00197877,0.0037296875,0.033541176,0.01591496,-0.044203725,0.091273226,0.080183186,0.0761179,-0.08174556,0.09059052,0.045499455,-0.052672543,-0.0249108,0.03214865,-0.0086521795,0.041114092,0.015244907,0.04383177,0.017670093,0.03612384,-0.022262292,0.02622919,-0.033346407,-0.099668905,0.03719646,0.0826171,0.045175064,0.03299862,0.03881884,0.04213378,0.012316055,0.038035147,0.09328847,0.0029240388,0.057193294,0.0416669,-0.033778094,-0.089102,-0.0016318267,0.063091606,-0.012804232,0.06601791,0.090626545,-0.03331266,-0.0012832386,-0.0317366,0.024434466,-0.16243047,0.011951444,0.04239352,-0.0033688112,-0.002249398,-0.016243372,0.03500357,-0.067849584,0.0021559948,0.03511376,-3.8579426e-08,0.0013976386,-0.11117181,0.07632092,-0.048385948,0.07670927,0.011131561,0.025795093,0.011883211,-0.046341978,-0.026894592,0.035922088,0.10843293,-0.013283498,-0.052957404,0.041675348,0.01332346,-0.04917384,0.033144295,-0.0048902645,-0.0160225,-0.016784607,-0.02422862,-0.0715359,-0.00026610307,-0.020831399,-0.017551549,0.010292905,-0.03617073,0.030921679,-0.039184775,0.0076423944,0.06751125,0.031533472,-0.008080122,-0.13115354,-0.011651679,-0.045686945,-0.0050423634,-0.03270257,0.02559028,-0.04651719,0.04602946,-0.07541092,-0.013556157,0.04948346,0.021515453,-0.03145659,-0.0023940203,0.0046230406,-0.017813822,0.028039377,-0.021201117,0.027732054,-0.013818503,-0.09638947,0.06445155,0.0014110644,-0.057942342,0.015233569,-0.037151743,-0.01926199,0.06212965,0.15450081,-0.014902178 +1.14.12.13,"A multicomponent enzyme system composed of a dioxygenase component and an electron transfer component. The latter contains FAD. The enzyme, characterized from the bacterium Burkholderia cepacia 2CBS, has a broad substrate specificity. Substrates include 2-fluorobenzoate, 2-chlorobenzoate, 2-bromobenzoate, and 2-iodobenzoate, which are processed in this order of preference.",384,1.0,-0.0008655291,-0.09051651,-0.10590174,-0.062444918,0.057796743,0.007946968,-0.04250698,0.08158263,-0.018493036,-0.068241,0.033649527,-0.18103924,-0.0028355636,0.03428966,-0.07716949,0.02652644,-0.039401475,-0.008051183,0.021269485,0.045881927,0.006008882,0.040976014,0.03343434,0.01641693,-0.024736352,0.07841355,0.02586344,-0.024587892,0.018781576,-0.068502545,0.022753207,0.05977937,0.1029552,-0.013540832,0.025634283,0.13947691,-0.01719225,-0.021877263,0.03216889,0.009589192,0.004778743,0.02644265,-0.010596854,-0.026984014,0.024545394,-0.017255023,0.013962113,0.01643778,0.008487028,-0.045367446,-0.05404486,-0.07401834,-0.04252987,0.1086131,-0.015869733,-0.019134277,0.009751943,-0.04290097,-0.06363397,-0.034048293,0.026219726,0.004119716,0.023487955,0.04715966,0.08112331,0.0037808728,-0.090924844,-0.068514965,-0.011582967,-0.05638486,-0.09007345,-0.06859461,-0.0020371962,0.008695546,0.044998243,-0.038376924,-0.03497438,-0.015862476,0.059851937,-0.07985924,0.036096167,-0.0066653816,0.04217529,0.039953027,0.032269448,-0.025045896,0.027455064,-0.01044002,-0.00421112,-0.006625573,0.051127903,0.043909766,0.05589308,-0.035671588,-0.074146,0.03379622,0.043817807,0.058515754,0.109399736,0.011033057,-0.0007156014,0.00717698,0.04610119,-0.02501672,-0.04951815,-0.09926077,-0.040253203,0.09252653,0.04507899,-0.073617,-0.014024223,-0.011402936,-0.02185039,-0.026162118,0.020912534,0.03809018,0.059243508,-0.08588643,0.035474747,-0.016726809,0.021590365,-0.051018953,0.049235053,-0.0154144475,0.06249689,0.025910722,-0.08818662,1.2685539e-33,0.052601274,-0.01318043,-0.07012898,-0.012274714,0.030678306,0.004663764,-0.076996595,-0.009629696,-0.029844817,-0.012328329,-0.006086826,0.047302622,0.0058288425,0.07034442,0.06617012,-0.045822266,-0.027560918,0.05526276,0.15432301,-0.0005557477,0.060649987,0.089809634,-0.030799203,-0.020898093,0.09729758,0.021922335,0.010508187,0.04294299,-0.044588827,-0.006535063,0.06184646,-0.035557177,-0.10515029,0.004093368,-0.022774378,-0.02933783,-0.071573295,-0.052103527,-0.066491395,-0.030745964,-0.0152630545,0.0043068305,0.017739767,-0.040850468,0.06716766,-0.09458137,-0.03669096,0.1062974,0.050524954,0.04565117,0.001077828,-0.0069397734,0.12793696,-0.032425407,-0.024963599,0.04630601,-0.04941893,-0.0033973204,0.039638847,0.03462008,-0.02594728,0.08562819,-0.080974944,0.06732571,-0.03025139,-0.046420444,-0.030169427,-0.0029333672,0.04232987,0.103944525,-0.03359931,-0.026385065,0.019641956,0.03810556,-0.010492799,-0.0866123,-0.037506733,-0.07067427,-0.03577309,0.04416646,-0.02756244,-0.018588798,0.00812605,-0.07907457,-0.046891905,0.025884043,-0.08906439,-0.050313026,-0.027189938,-0.006747195,0.0068124915,-0.045020156,-0.0375466,0.020089379,0.040127944,-1.5013359e-33,0.068066955,-0.0948649,0.0050925864,-0.021464609,0.007595471,0.019117052,-0.022971824,0.046255153,0.03131738,0.061070386,0.07219815,0.040845133,0.05162152,-0.020266643,-0.004639413,0.0644893,-0.014009442,0.06546292,0.054825887,-0.046887483,0.037253194,0.052953463,0.025181394,-0.028225025,0.026445882,0.048505113,-0.04311047,0.008550286,0.03961602,0.05532659,-0.060816564,0.010464326,0.019793976,0.040621057,-0.05967087,-0.014372802,-0.03915177,0.022056766,0.0018159172,0.06732495,-0.004528284,0.06236753,-0.033106238,0.07891837,0.022782885,0.05564663,-0.05791426,0.02686175,0.0833598,-0.05733396,-0.040484767,-0.016821241,-0.0046408665,-0.008920687,0.020281674,0.039199334,0.0022491605,-0.0002024438,-0.015919397,-0.028447531,-0.0034417463,-0.123861074,0.002603237,-0.019717617,0.106154256,0.030329928,-0.11294712,0.010729133,0.007466791,-0.010625261,0.069213465,-0.04827892,-0.024548722,0.039510593,-0.067177534,0.028207697,-0.05996463,-0.027900675,0.032072663,0.0703899,0.08011093,-0.016519133,0.055256158,0.002893629,-0.058164913,-0.12759122,0.017856358,0.036317322,-0.025520515,-0.03388998,-0.004920181,0.036857817,0.01306597,0.039406795,0.055101007,-3.7404142e-08,0.04576368,-0.077779464,0.02706927,-0.062151708,0.015621472,-0.01288473,-0.052466806,-0.030459868,0.026008269,0.0075788237,-0.04046408,0.099891245,-0.040462244,0.030560793,0.08420029,0.047249217,-0.03084337,-0.004217049,-0.052252974,-0.0019197692,0.025888339,-0.027137876,-0.06198672,0.079754665,-0.010843624,-0.03824992,0.026304884,0.049043674,0.036304668,0.01516766,-0.043807376,0.039758082,0.015294596,-0.033029143,-0.06877668,0.020559587,-0.09522524,-0.07982187,-0.08795927,0.04308536,0.055782825,-0.059489574,-0.06542891,-0.0088539785,0.058097076,0.010722908,-0.026111208,0.013347204,-0.007091076,-0.023696734,0.04813294,-0.026911758,0.033488125,0.012620159,-0.058973607,0.034070086,-0.008648432,-0.07446154,0.046625003,-0.041545205,0.051965855,0.09403737,0.21591784,-0.03300042 +1.14.12.15,Has been shown to contain a Rieske [2Fe-2S] cluster,384,0.99999994,-0.040295586,0.011887049,-0.016680118,0.062396538,0.12871066,-0.03354405,-0.0733071,0.023360085,-0.0017591331,-0.068788424,-0.0003589551,-0.09241785,0.027988898,-0.051300216,-0.021650653,-0.03986624,0.013563652,-0.029763106,0.068305366,-0.013654531,-0.009414271,-0.021127256,0.0059276493,0.0036420543,-0.031439047,0.060228977,0.08295623,-0.024059286,-0.01157094,-0.14614671,0.027291123,0.032913204,-0.06705931,0.023940146,0.010399493,0.07242033,0.0818877,-0.00084798294,-0.023967424,0.016566828,-0.0073406943,-0.035298306,0.038974646,-0.007853954,-0.01569898,-0.041655697,-0.07931971,-0.051548045,-0.008555614,-0.079560325,-0.050114933,-0.022588914,0.03522579,0.08805887,0.057397243,-0.0054223393,-0.031353272,-0.02684302,0.04292206,-0.016319785,0.13395429,-0.050687388,0.048444327,0.02477329,-0.02642675,0.047810107,-0.012411606,-0.037712038,0.074055344,-0.07776163,0.03625461,0.075747535,-0.01683135,0.028479926,0.040570084,0.067391366,0.045848582,0.0826399,0.059691608,-0.03752292,-0.06280077,-0.038541447,0.127473,0.0064412868,0.030875474,0.0112246,-0.04814597,-0.093142,-0.0036550562,-0.037914775,-0.0031888979,0.05464814,0.022656258,-0.008494157,-0.046811573,0.018680252,-0.06700686,0.020946853,0.022387743,0.036642518,-0.030159079,0.04283578,-0.01668347,-0.028980795,-0.01599258,0.04002513,-0.04612375,-0.009450179,0.05364772,-0.017156772,0.05172311,0.07703079,-0.02203972,0.029672023,-0.030312186,-0.033392094,0.09959141,0.023576463,0.024161674,0.024514724,0.031113347,-0.0028349825,-0.093279056,-0.034680173,-0.048679072,0.033322133,-0.1255447,-1.6552654e-33,-0.056003023,-0.056996744,0.007863526,-0.021015693,0.0030362909,-0.008533969,-0.064833805,-0.020883974,-0.051132467,-0.08185009,-0.023828538,-0.013468781,-0.005814392,0.0113497935,0.023904812,-0.110692576,0.074891776,0.053746838,0.018510832,-0.13781685,-0.03402295,0.06422873,-0.028032718,-0.059505552,0.014729458,0.07467384,0.07779092,-0.10800401,0.058173582,0.03998988,0.006719004,0.007481687,-0.0016525923,0.011103599,-0.0977831,0.004455258,-0.0008995038,-0.04433706,-0.010812838,-0.06143741,0.017624095,0.01806643,0.0036849924,-0.08640268,0.03358479,-0.1005697,0.023258716,0.029576791,0.11051565,0.04180449,-0.05878142,-0.025004828,-0.026599968,0.07591502,-0.00017609932,0.014640512,0.0575717,-0.017469717,0.08775474,0.07059663,-0.010271529,0.045131825,-0.0009980196,-0.007905836,-0.0055396156,0.05719106,-0.03001345,0.018421803,-0.044806004,0.07886705,-0.022585128,0.03753972,0.059236225,-0.01318323,-0.016605522,-0.06395943,-0.024295833,-0.040739916,-0.0012250167,0.03836601,-0.016019663,-0.07330075,-0.01982878,0.004359664,-0.013730311,-0.066748336,-0.020958306,-0.03529983,-0.06468671,0.06993692,0.040387478,0.053377524,-0.07183341,0.02420282,-0.077653535,7.3712813e-34,0.009017775,0.043950856,0.010545648,-0.02441841,0.021514235,0.017777003,0.01093823,0.06184573,-0.045032416,-0.009025191,0.09331346,-0.009417762,-0.011891968,-0.09755234,-0.019458016,0.00914645,0.10556192,-0.0047935564,0.091357455,-0.010465703,0.022940869,0.027212499,0.049148407,0.040606312,0.017381227,0.010094119,0.032733444,-0.011533415,-0.07155086,0.071391426,0.027916614,-0.025912596,-0.017060665,0.046998575,-0.01685207,-0.060798656,0.023459636,-0.05044772,-0.008853475,-0.09454276,-0.05542678,0.006434008,-0.11740016,0.12657744,-0.0012050626,0.013697627,0.049895056,0.01029939,-0.0019448804,-0.04316054,-0.055717345,-0.07495489,-0.0013412326,0.09410306,-0.11032639,0.014526917,-0.0661212,0.07307313,-0.047239307,-0.024905428,0.070165835,-0.027119897,-0.05471052,-0.055938963,0.09984593,-0.053238336,-0.012126741,0.05205038,-0.041214973,0.025615906,0.092590466,0.027410164,0.014423627,0.013451077,-0.027189719,0.011686575,-0.012478041,-0.046665464,0.0109386295,-0.010411361,-0.008020612,0.035338134,0.008673431,-0.008160642,0.09338234,-0.051086992,0.019030282,0.053675648,0.053906824,0.009095956,-0.042897537,0.023219125,-0.05634152,0.047888458,0.05914079,-1.898568e-08,0.043256957,-0.08928058,-0.039274953,0.00934043,0.03404472,-0.087164685,-0.02859077,0.10913288,-0.10126423,0.061482105,-0.0064739976,0.009584369,-0.061088108,-0.035997983,0.1264555,0.025903206,0.052642133,0.06722233,-0.030476242,0.024022872,0.0008749611,-0.017780138,0.05138975,-0.007215466,0.011572357,0.0054045203,0.001491205,-0.059221074,0.020052502,-0.07766267,-0.009329078,-0.054495897,0.048503093,0.0105634825,-0.012897741,0.0735251,-0.09415736,0.052403152,0.033208128,0.002713576,-0.010626837,0.072542906,0.037139997,0.053873297,-0.0593663,0.038764875,-0.043994352,0.02067357,-0.020519987,-0.0785699,0.0048543755,-0.055094253,-0.027380545,0.02035893,-0.09683662,0.011958609,-0.122674,0.037088703,0.07364554,0.018104644,0.10443015,-0.028286671,0.030956939,0.041439123 +1.14.12.16,"3-Methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also substrates. Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers",384,0.99999994,-0.027014574,-0.06928654,0.010006512,-0.09227473,0.10402091,-0.040909797,0.05078579,0.06638908,0.027584912,-0.033632502,0.052121647,-0.04482509,-0.0854081,0.02180368,0.047559943,0.10879197,-0.085572615,0.0039049326,0.011953907,-0.030096387,-0.0033354699,-0.05321158,0.009818237,0.03641845,-0.0068770642,0.030737782,-0.0076184943,0.09113343,0.07288404,-0.026222024,-0.044915844,0.0054760696,-0.044006586,-0.016644629,0.013625401,0.035345376,-0.023032945,-0.014838458,-0.022526937,-0.005537406,0.055430625,-0.019769074,-0.010116869,-0.0048966925,0.012936903,-0.017800057,0.0053951037,0.08671112,0.0507291,0.022002755,-0.026199164,-0.04780327,-0.020999823,0.077629864,0.039846443,0.09334002,-0.0838837,0.103735626,-0.024328174,0.08786858,0.024943544,-0.0033631008,-0.07062128,-0.0057055615,0.019163707,0.10717998,0.017776301,-0.047306772,0.024707077,0.027792687,-0.048233826,0.002678001,-0.048263364,-0.0057157963,0.024023404,0.07083971,0.012914921,-0.013669206,0.016652329,-0.05480325,-0.038539406,0.01187059,0.063883334,0.046448443,0.007984617,-0.02008716,-0.06867564,-0.002722523,0.024172757,0.0043438314,0.021501373,0.0021356444,-0.014417155,-0.038482152,-0.020522952,0.07055092,-0.002964467,0.02619713,0.083637446,0.05129526,0.030206453,-0.0013612297,-0.07033906,-0.057679363,-0.060872957,0.08064609,0.03499853,-0.02854255,-0.09086045,0.009187583,-0.019509783,-0.031531792,0.09117104,-0.06570252,-0.052226238,-0.043759067,0.04051862,-0.01969866,0.029302225,-0.061617766,-0.008137196,0.026450124,0.008444786,-0.014493022,-0.041171692,-0.025479186,-0.0052424315,1.9165216e-33,0.02867103,0.08618803,0.03161204,0.026475815,-0.026289336,0.019419335,-0.04118231,0.04240076,-0.0698062,-0.029397547,-0.08017648,-0.07060249,0.009578288,-0.009995086,0.032273762,-0.01777835,0.034059048,0.0028500177,0.047336154,0.006383517,-0.039753113,0.10922246,-0.03711362,-0.0304924,0.01874909,-0.033250414,0.008600611,0.009767059,-0.053022016,-0.047075592,0.03562778,-0.054646753,-0.010319444,0.0029272137,-0.0077677425,0.006781665,-0.084649935,-0.0015042163,-0.0020593817,0.053152826,0.033219922,0.06055357,0.03453882,0.010930308,-0.0042288294,-0.033397388,-0.00068602385,-0.01864141,0.059735853,-0.07789332,0.05813234,-0.020362176,-0.032969765,-0.08903137,-0.04799666,-0.032884587,0.023871057,-0.067469366,0.034009002,0.040235277,-0.058928233,0.009602768,-0.04412147,-0.03697615,0.025175797,0.03354254,-0.09876192,-0.1010634,0.02594949,0.049247984,-0.055404853,0.01531788,0.03192795,-0.04450955,0.046496455,-0.03921706,-0.09139223,-0.084577106,0.08418786,0.019532511,0.027908128,-0.010211512,-0.0071258806,0.012590021,-0.131549,-0.031751,-0.018031143,-0.038005713,0.052070934,0.0465917,-0.05042331,-0.0025809451,-0.009680851,-0.047044408,-0.0028172897,-3.0370158e-33,0.01872927,-0.041664813,-0.020150859,0.00012274749,-0.042195935,0.103240676,0.03893339,-0.0420332,0.03780117,-0.00024124664,0.09784619,0.0040901704,0.048910256,-0.004315147,-0.015830446,0.022355977,-0.059576444,0.08056548,0.06449457,-0.06130105,-0.003944837,0.07411601,-0.009197483,0.11084757,0.0015130138,0.034536313,0.005570097,-0.0116214845,0.07415156,0.15133809,-0.045362677,-0.06667847,0.077366084,0.020662863,0.0470789,0.061165866,0.04467799,-0.0058942735,-0.11465843,-0.027008997,-0.0022804262,0.0100840805,0.072336495,-0.0049180216,-0.08028894,0.06831479,-0.058774043,0.03026878,-0.14153668,0.012880303,-0.009491365,-0.00044642965,-0.11852266,-0.0023901085,0.050974917,0.08593212,-0.085955225,-0.05546,0.087969,-0.004669681,-0.027871087,-0.061497122,-0.027613904,-0.050219018,0.065952286,0.06926017,-0.06284522,0.06314813,-0.0072912113,-0.05595777,0.02027605,0.05148249,0.037866767,0.006248155,-0.038779285,0.0005300778,-0.009535663,-0.037412617,-0.011000837,0.034840498,0.06518404,-0.02879035,-0.0014410418,0.020960623,-0.09788041,-0.05645104,0.043893114,0.103779,0.0027454656,0.03439762,0.04719527,0.0049145273,-0.059537817,0.10502104,0.073931,-3.734068e-08,0.059702568,-0.027412292,-0.0064280867,-0.015664266,-0.13290998,-0.027106386,0.07520843,0.05753751,0.018726535,0.0050861207,0.059688307,0.055998784,-0.021854391,-0.012037638,0.073753186,0.046887007,-0.04840293,-0.0029877066,-0.044458278,0.00013280932,-0.018640427,0.035178125,-0.08078661,-0.033565998,-0.008471729,-0.07202793,-0.011849244,0.08869906,-0.024475887,0.0075392732,0.032778922,0.011991413,-0.026767883,-0.09308461,0.016387131,0.03822529,-0.07798643,-0.03978407,-0.0037167477,-0.013224766,-0.03377187,-0.026784018,-0.08947995,0.015065154,0.058871757,-0.069034904,0.02779518,0.028387291,-0.04377054,-0.020553263,0.017410923,-0.0030262012,0.086319044,-0.05480747,-0.08516213,-0.07639936,-0.059651785,-0.014262288,-0.05930773,-0.098633975,0.047773864,0.001260057,0.19571318,0.01217784 +1.14.12.17,A flavohemoglobin (FAD). It has been proposed that FAD functions as the electron carrier from NADPH to the ferric heme cofactor,384,1.0,-0.046981975,-0.027950715,-0.1251501,0.032090954,0.027371362,0.068283595,0.029963022,0.062319558,0.0068914895,0.020024396,-0.030157428,-0.023458395,-0.12220526,0.032765385,-0.04433172,-0.073694296,-0.025021888,-0.0064762817,-0.042936433,0.021347502,-0.006121947,-0.013661124,0.07674425,-0.039996915,0.016223894,-0.04618115,0.017808625,-0.052606292,-0.031736422,-0.08676606,0.05277419,0.0402173,-0.012239157,0.012512619,-0.10366176,0.036157988,0.049924225,-0.08644455,0.0013935432,0.016806781,0.038922794,-0.029002149,-0.059672784,-0.015162164,-0.017868796,-0.00658279,0.030218339,0.026373826,-0.01636213,0.05195158,0.0021687285,-0.0035683522,-0.089669295,0.073213615,-0.017118365,0.036374886,0.02172248,-0.038816195,-0.015838308,-0.005031257,-0.047895096,-0.01579334,-0.009715202,0.06909408,0.032817133,-0.13353,-0.009091486,-0.033431347,-0.011092139,-0.04344221,-0.011694961,0.010678503,-0.0587915,-0.035180937,0.013529294,0.11952397,-0.032958522,-0.0028886374,0.11480373,0.035889782,0.017301245,0.017956363,0.046041775,0.114599034,0.044444412,0.04525167,-0.07838469,-0.029376643,-0.15854023,-0.014048604,0.0104765585,-0.0058588646,0.034849178,0.03608089,-0.09027204,0.033972647,0.09698626,0.035156026,-0.00847393,-0.04452756,0.0028859174,0.06636239,0.048698597,-0.0018363323,-0.09246441,-0.08266018,-0.012511869,0.09265109,0.006904353,-0.046596907,0.014309027,-0.036591187,0.04856009,-0.10053452,-0.025315568,0.08303345,-0.04487209,-0.006919452,-0.02432464,-0.0379278,-0.07384936,0.029462066,0.013485223,0.044032507,0.0524986,-0.022445992,-0.08948074,2.2924733e-33,0.10470873,-0.018012885,-0.0036647574,0.019350052,-0.0323581,-0.012330032,-0.09487103,-0.043399643,-0.0036571063,0.048265446,-0.04397013,-0.0069119926,0.040142473,-0.0358758,0.011162148,-0.0053419047,-0.0932633,-0.12713881,0.062997125,-0.011010758,0.06117905,0.04411281,0.032147687,0.028520115,0.06332511,0.01435585,-0.094088115,0.07923016,-0.031998247,0.060375582,0.029197419,0.00149668,-0.09056723,-0.051253613,-0.027253145,-0.05955372,-0.084427476,-0.0359257,-0.0828222,0.04287033,0.03119237,-0.033520065,-0.058427215,-0.010593188,0.057401642,-0.07184057,-0.011732406,0.032185365,0.07175073,0.1004151,0.011281224,-0.08529137,0.10124132,0.06174462,-0.020328492,0.033632476,-0.028722007,-0.01732536,0.026376698,0.056585446,0.08404569,0.05956607,0.025574373,0.091768324,-0.0142629305,0.051463053,0.029383995,-0.05213627,0.010627434,0.0713259,0.021547424,-0.0072921226,0.06821031,-0.075125255,0.063451454,-0.02275685,-0.015931748,-0.007444691,0.05358283,-0.057753522,0.12438594,-0.021566411,0.021619042,0.015305078,-0.041418906,-0.027431855,0.0010795789,-0.008622134,-0.039283626,-0.00030035034,0.08133616,-0.052356817,0.04270483,-0.076974034,0.0097531,-2.8370402e-33,0.109325394,-0.031844314,0.0065599503,-0.07345229,-0.023265557,0.093920715,0.059171002,-0.07009725,0.012178262,0.012796455,0.070580006,0.0648809,0.007436921,0.0048098294,0.03484636,-0.010705637,-0.063387625,-0.047029108,0.030252516,0.024374269,-0.066310115,-0.031126365,0.051874235,-0.03345593,0.057105567,-0.04309834,-0.05668721,-0.07403401,0.008717968,-0.0068006273,-0.013050791,-4.225484e-05,-0.07726099,-0.050221995,-0.06009445,-0.07209269,0.02636876,0.061338335,0.04259641,-0.01200634,-0.058282018,-0.014024758,0.066646755,-0.012999828,0.08688241,0.008922819,-0.11506972,-0.024309438,0.06388501,0.040388115,-0.035498444,0.059853356,-0.07184122,-0.011387045,0.005759024,0.08270878,0.00514528,0.03954004,0.040190347,-0.044623148,-0.03531776,-0.07794779,0.0986577,-0.008551599,0.060910337,0.05715142,0.009842927,0.12382011,0.04934623,0.032295763,0.10694823,-0.0044103283,0.03498078,0.03511275,0.076026715,-0.058466896,-0.0024387196,0.047064237,0.022449272,0.068491414,0.029459534,0.041089434,-0.047328196,-0.048419945,0.041688588,-0.07240102,0.0004833567,0.016671533,-0.029165007,-0.027523277,-0.03745678,0.0026956405,0.03744419,-0.02938958,0.049622104,-2.8091636e-08,-0.008827539,-0.0278237,-0.036725085,-0.021953283,0.082186565,0.013112696,-0.061964992,-0.047682047,-0.04253952,0.024160607,0.023179745,0.13036118,0.028401373,0.02933211,0.0715331,-0.0201411,-0.031294126,-0.03051912,-7.6272954e-05,-0.02550872,-0.021808473,0.041433454,-0.026959319,0.06626792,0.02219479,-0.033350073,-0.023288457,-0.06400048,0.0200687,0.022677552,-0.019340292,0.041328855,0.028454566,-0.025319897,-0.05118605,-0.024045672,-0.014907861,0.0197513,-0.06044476,0.037644565,0.012905952,-0.06717075,0.049314678,0.011782769,0.012595738,0.053200558,0.03505912,0.0012857069,-0.06782689,0.021711955,-0.01436882,0.012719587,-0.02120004,-0.03677536,-0.09290108,-0.013041956,-0.038248662,-0.07382838,0.020247282,-0.06178571,-0.0055962447,0.025547177,0.055281572,-0.02679521 +1.14.12.18,"Requires Fe2+. The enzyme from Burkholderia fungorum LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske-type iron-sulfur cluster and a catalytic mononuclear nonheme iron centre. Chlorine-substituted biphenyls can also act as substrates. Similar to the three-component enzyme systems EC 1.14.12.3 (benzene 1,2-dioxygenase) and EC 1.14.12.11 (toluene dioxygenase).",384,1.0,-0.02434354,-0.059315935,-0.123544544,-0.0026492644,0.11469604,0.058328766,-0.09328733,-0.00027627984,0.025418736,-0.12045965,-0.011051217,-0.11335542,-0.05009716,0.035793625,-0.059676852,0.045897815,-0.042670906,0.018832967,0.018198183,0.068682104,0.05664658,0.03663704,-0.0074289436,0.030212887,-0.03561574,0.053413767,0.08480266,-0.047341023,-0.03701299,-0.06917396,-0.06959682,0.0043797237,0.082003534,-0.074598104,-0.0057648844,0.07717359,-0.01416441,-0.015162098,0.05512863,0.025045415,-0.012589127,0.015786512,-0.031449594,-0.086248286,-0.034639955,-0.084176645,0.04916422,-0.02320282,0.06490279,-0.018421052,-0.030855559,-0.02267841,0.0072095674,0.08286775,0.017467542,-0.026589222,0.009990663,-0.03825563,-0.02099267,-0.034907006,0.017929481,-0.05472553,0.030320289,0.003794328,-0.018044755,-0.030582994,-0.03575252,-0.04922652,-0.010865672,-0.11627004,-0.055816736,0.014261292,-0.0040112636,0.02154842,0.015132162,0.062403273,0.0423783,-0.023146484,0.052140385,-0.04323285,-0.008469994,-0.030645976,0.05361972,0.092997156,0.049576078,-0.013967036,-0.0265819,0.02251432,-0.028713526,0.0056613362,0.044804465,0.050367393,0.00453916,-0.02715116,-0.028521338,0.06379309,0.016051536,0.06080069,0.06584549,-0.023312133,-0.05032198,0.054804385,0.015628079,-0.07497535,-0.0032179297,-0.008440956,-0.004444199,0.11167326,0.09226033,-0.036599673,0.02739678,-0.042207137,0.094533674,-0.018654322,0.008315674,0.05157712,0.060707714,-0.0979289,-0.03084149,0.049016207,0.07541732,0.0031920655,-0.002671896,0.060521338,0.015980331,0.060738817,-0.13401401,5.435778e-33,0.10138938,0.06710378,-0.007019334,0.038410123,-0.028222935,-0.0024968064,-0.10100204,-0.021833612,0.0037510425,-0.07473948,-0.0017152708,-0.012467374,0.0037488742,-0.07191442,0.019492213,-0.09579528,-0.019235533,-0.015467822,0.06550176,-0.009127724,0.029242141,0.04359285,-0.05619918,0.0055064075,0.06836055,0.051133294,0.00886565,-0.02190151,0.0060345414,0.0008031533,0.08038316,-0.050788555,-0.11340848,-0.0076244054,0.0023548189,-0.041019626,-0.014924359,-0.027104422,-0.084005095,-0.035237327,0.032531533,0.054637875,-0.03897355,-0.085007526,0.103036806,-0.15397207,-0.061086357,0.17900388,0.055604953,0.13994464,-0.049637537,-0.0019556857,0.08583331,-0.016392378,-0.06352883,-0.010429731,0.001653171,-0.010887354,0.058072932,0.095231876,0.02893951,0.11664146,-0.012597704,0.07027163,0.00322662,-0.017631555,-0.025701122,-0.0048728613,0.0008847574,0.05391576,-0.025888465,0.03985743,0.011033571,0.057218842,-0.0012724467,-0.11977475,-0.042565066,-0.082345225,0.030665841,0.038096286,0.01646523,-0.013779981,0.023508387,-0.013503745,-0.088379174,-0.0033962205,-0.047277465,-0.03213556,-0.052785642,-0.014639064,0.037425876,-0.050009247,-0.05480732,0.008126001,-0.025673905,-4.9762287e-33,0.067325674,-0.11123151,0.045137018,-0.058474354,-0.04911494,0.06395415,-0.021760011,-0.009996244,0.010894369,0.0045634545,0.08608701,0.015576573,0.041160412,-0.045476276,0.05552775,0.07912333,-0.014242088,0.029537663,0.030222885,-0.06143123,0.01862281,0.08670892,-0.023001637,0.04407025,0.053918,0.038888182,-0.03658781,0.009759528,0.05166324,0.09325474,-0.027421411,0.019422824,-0.0233995,-0.00855549,-0.008336282,-0.0010267836,-0.065049894,0.018601853,0.053980008,0.010762109,-0.00211029,-0.028845022,-0.043035205,0.039536882,-0.020872705,0.047073722,-0.06562466,0.016429836,0.08706118,-0.05369655,-0.05237507,-0.048721023,-0.053008918,-0.011115574,0.008591848,-0.0030718148,0.04710174,0.016453125,-0.018575814,-0.02509282,-0.0092045525,-0.039578553,0.014267084,0.0053835926,0.0030968382,0.07150349,-0.055105973,0.06924228,0.03199647,-0.020974917,0.05435528,0.011267865,0.091981955,0.025806727,-0.038578846,0.012345346,-0.0025638654,0.0026547671,0.0139066465,0.01834699,0.024348935,0.010450873,0.013860199,-0.013100897,-0.0032152995,-0.09963068,-0.002397659,0.024158271,-0.0555017,-0.0052555543,-0.035927676,-0.005246901,0.029470949,0.0337684,0.018913837,-4.7447887e-08,0.016097926,-0.07033341,0.0641143,-0.047967575,-0.021361366,-0.0035729224,0.002374934,-0.050081264,-0.024302706,-0.025634838,-0.02495128,0.06481613,0.02502094,-0.013072914,0.062774464,0.02397603,-0.0031300439,0.046481553,-0.029377604,0.005011438,-0.052841265,-0.04524539,-0.1081254,0.022029625,-0.0015665368,-0.045462485,0.013862068,-0.0017053928,0.09876997,-0.013670609,-0.00035312294,0.01619402,-0.02092107,-0.0009324678,-0.074303836,0.01107705,-0.10369338,-0.007996357,-0.10625239,0.049365044,0.03928559,-0.04955022,-0.07005324,-0.028306521,0.0424776,-0.0050350516,-0.041092534,0.025351582,0.01554363,-0.05562271,0.05816313,-0.03370905,0.07629755,0.014116477,-0.0698872,0.103304245,0.050763253,-0.060537875,0.04676999,-0.024984676,0.0072807404,0.056824714,0.1426575,0.004249898 +1.14.12.19,This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. It catalyses the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3-phenylprop-2-enoate.,384,0.99999994,-0.024773292,-0.0144932065,-0.035367783,-0.024205673,0.14743596,-0.008188726,0.0036160243,0.014106478,0.00818682,0.01792034,0.028832205,-0.016145745,-0.051097278,0.02232662,-0.049408536,0.08782069,-0.16988412,0.08088331,-0.044015367,-0.07865127,0.061216686,0.017783752,0.061885342,0.014214932,0.041195963,0.020792406,0.051468562,-0.0019558528,0.018944677,-0.047930762,0.09290634,-0.033371143,-0.0032003864,-0.05520965,0.059568774,0.00046268068,-0.038869597,-0.04170452,-0.0368761,0.020586716,0.013378021,-0.012766826,-0.08893541,-0.07445066,-0.043234766,-0.05920702,-0.0277326,0.012337383,0.019803021,-0.06743037,-0.013521233,-0.02395422,-0.034115862,-0.0037259776,-0.030992828,0.05468799,0.0032046144,-0.007137464,-0.0061058495,0.055276014,0.08267805,-0.01323473,-0.032095022,0.023591703,-0.007503643,-0.050344374,0.008296357,-0.021288794,-0.021710038,0.03376192,-0.071885146,-0.10127979,-0.08617474,0.009622373,0.017887931,0.017384062,0.008998975,-0.05120484,0.033226732,-0.043127038,0.078896046,-0.016647557,0.033285055,0.02912092,0.07153683,-0.0072404533,0.010763766,-0.05207114,0.1023257,0.025321634,-0.04213497,0.0017842858,0.014904664,0.013111932,-0.0035115199,0.07132566,-0.006190797,0.046304602,-0.018542526,0.07129837,0.027967349,0.053023066,-0.010123876,-0.16707383,-0.030250348,0.016510027,0.02893372,0.09105015,0.04914333,0.0012128094,0.0025404443,-0.079038925,0.0803899,-0.0087672975,0.000754998,0.15386833,-0.0070983013,0.012217559,-0.05222392,-0.0044074035,-0.0068193814,-0.0051277895,0.0059929104,-0.01221828,-0.09427047,0.024507629,-0.066237144,3.8286905e-33,0.024081793,0.007481134,-0.03204709,0.043939516,0.0022696038,-0.027012236,-0.09768623,0.03390762,-0.06456439,-0.07996455,-0.07476594,-0.08297135,0.016030755,-0.035252273,0.0045970967,-0.10456208,0.0076248716,0.11923602,0.04923424,0.029610638,-0.0069827307,-0.0003646498,-0.06534633,0.01659131,0.06480796,0.043829042,0.0047350475,0.01156364,0.020768115,-0.031269424,0.06952809,-0.04505939,-0.17987053,0.002848777,0.0060710413,-0.049457274,0.0023412008,-0.060738783,0.0055086133,0.055955585,-0.033883613,0.025274212,0.020330068,0.017101834,0.03549963,-0.010424706,0.047914896,0.10840929,0.070075326,0.08246732,0.048757557,0.0014890577,0.05272437,0.03352707,-0.06369619,0.040756278,0.006424498,-0.049371116,0.07567214,-0.047215935,0.0066835857,0.03388107,-0.031976417,-0.0031054663,-0.0017410946,0.045934286,-0.03903527,-0.060443725,-0.0005491341,0.065813474,-0.07640592,0.018292142,0.044612437,0.028891457,0.0730013,-0.060342364,-0.09201559,-0.043489438,0.008883174,-0.017584857,-0.06761986,-0.011427108,0.003737274,0.0053949603,-0.024273345,-0.027957978,-0.091609396,-0.050172467,0.012758415,0.045552753,0.06993416,-0.11217639,-0.025934534,0.0012312214,0.04000082,-3.59739e-33,0.031238612,-0.030549508,-0.011904828,-0.061445985,-0.021513343,0.006268722,-0.006675467,-0.0076325657,-0.020964963,-0.032265134,0.06133152,-0.06429726,0.06616806,-0.037007466,0.041884128,0.018293383,0.03839599,0.04756189,0.04172711,-0.031698383,0.098442234,0.018203666,0.0060933447,0.0696922,0.0034401533,0.063695766,0.06427687,-0.008994466,0.054437183,0.0459636,-0.03508893,-0.0045378483,-0.042240795,0.07138971,-0.033118967,0.12694824,0.0047079283,-0.050580077,-0.047765654,-0.020982627,-0.026998589,0.028030427,0.021617876,0.04872589,-0.003519841,0.032253418,-0.042281903,0.06160159,-0.009104676,-0.11796318,0.013276872,0.08610829,-0.053259823,-0.038039718,-0.013285027,0.06705478,0.018969363,-0.016379263,-0.075732164,-0.00944025,-0.015723957,-0.023483116,0.087859504,0.04405514,0.018403357,0.044165418,-0.018782498,0.07465555,0.0058648954,-0.0802377,0.068697974,-0.02387059,0.036180116,0.06444685,-0.02640452,-0.03216079,0.013432347,-0.050389346,-0.0017263789,-0.030297056,0.015617084,-0.070553,0.032235175,-0.07058043,-0.05356407,-0.13133487,-0.009077843,0.031111056,-0.022666106,0.02281869,0.0008520809,0.03853104,-0.043567203,0.08148038,0.081346005,-3.31783e-08,0.034382544,-0.09049257,0.061956063,-0.057620253,-0.0012996331,-0.0077672563,0.047024872,0.056380935,0.03603303,-0.07253045,-0.02103118,0.06997639,0.0013583965,0.024402875,0.09698905,0.055613663,-0.013279176,0.05034187,-0.043659966,-0.08904485,-0.06164136,0.0060928343,-0.0934989,0.045276977,-0.018700182,-0.0254907,0.031365488,0.10727544,0.037924632,-0.026204629,-0.005686832,0.02232998,-0.008782613,0.057633914,0.0047982316,0.025491461,-0.07946335,-0.025446557,-0.06120262,0.022768302,-0.048016984,0.029547667,-0.042344898,-0.012088368,0.02561908,0.06309983,0.039690964,0.0490572,-0.017019201,-0.013150465,0.021672318,-0.024085034,-0.027070493,-0.0058406782,-0.10950245,-0.0061110933,-0.02829343,-0.014796713,0.000707554,-0.028530804,-0.07220592,0.06143058,0.16396394,-0.029439233 +1.14.13.1,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.14.13.2,A flavoprotein (FAD). Most enzymes from Pseudomonas are highly specific for NADPH (cf. EC 1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]).,384,1.0,-0.076960616,-0.06682295,-0.08477907,-0.03698752,0.066310816,0.062436935,-0.08051591,0.078658976,0.015873697,-0.034638975,0.008141767,0.002496881,-0.09926241,0.061957885,-0.078558974,0.023994688,-0.04413487,-0.009123194,0.0049519762,0.023618523,0.010455305,0.07952442,0.045522384,-0.013277502,0.057585027,0.021027999,0.027391337,-0.019428302,-0.016950827,0.015309246,-0.012045793,0.03034401,0.06699423,-0.043149997,0.017660176,0.045976892,0.022395626,0.018161647,0.04107932,0.027339742,0.05131717,-0.015833832,0.00712022,-0.047487803,0.0357608,-0.01984424,-0.015334042,0.06345305,0.04551287,0.009018889,-0.05455681,-0.033484954,-0.030317869,0.061943535,0.016261747,0.011915081,0.06911093,-0.060228124,-0.046412036,-0.033599872,-0.049150005,-0.08684231,0.025082285,0.044459626,0.044410747,-0.04536841,0.0016688681,-0.011666341,0.039558,-0.07285098,-0.07885543,0.0024961652,0.02697267,0.043160874,-0.004647229,0.044289168,-0.06379825,-0.062139433,0.034462705,-0.03232851,0.07410664,-0.031586446,0.04405717,0.09308662,0.0761191,-0.04119125,0.00084662373,0.035029765,-0.028203515,0.041503154,-0.016560977,-0.005584443,0.0046060295,0.012191579,-0.11273745,0.07822072,0.084637664,-0.012790967,-0.021001535,-0.06555156,0.0011813734,0.022647072,0.035053737,-0.04201039,-0.032323115,-0.028117208,-0.028300337,0.110346645,-0.019631,-0.04827311,-0.010476656,-0.030457102,0.0063425777,-0.105965406,0.0024966775,0.034505144,0.010326416,-0.049482256,-0.07240868,-0.02043638,-0.07398022,0.027680097,0.058976755,0.054246414,0.073590934,0.01850315,-0.15144569,4.5893343e-34,0.12739873,0.037458997,-0.04391546,-0.016239978,0.015431659,0.0027851304,-0.07518079,0.0105526205,0.017555404,-0.05887362,0.002023697,-0.013544295,0.0043672663,-0.05822096,0.04177315,0.06284789,-0.05962279,-0.05952246,0.024251834,-0.07963131,0.070102856,0.04881757,-0.04323831,0.03676476,0.033834912,-0.021530773,-0.051411964,0.038167845,-0.03619478,0.026149476,0.02255978,-0.06907165,-0.08900926,-0.02458571,0.029149113,0.020056793,-0.09063286,-0.08495671,-0.074250236,0.068537086,-0.0022387311,0.017189994,0.013315322,-0.040050507,0.05910619,-0.08834589,-0.08818889,0.1442103,-0.003631181,0.13444875,0.0054870746,-0.048331972,0.105804086,0.055566814,-0.060972936,-0.00045320534,-0.04816772,0.01005442,0.023838786,0.053023346,0.039425276,0.046484716,-0.057286542,0.10619742,-0.104653865,-0.018830992,-0.026001984,-0.0340909,0.032760423,0.12819429,0.009943797,0.0026516158,0.03859046,0.047711138,0.038690463,-0.07019624,0.010616431,-0.040150557,-0.011324791,0.027175887,-0.0014027695,-0.028706495,-0.049383048,-0.022580348,-0.09458844,0.058925707,0.03510229,-0.029953774,-0.03899281,-0.020010779,0.09058166,-0.08080839,0.0005556297,0.0041728136,-0.00025783668,-6.1649527e-34,0.08008031,-0.05613816,0.06776064,-0.045488358,0.00067573116,0.0465334,0.041959878,-0.034720577,0.02220615,-0.08071475,0.047304712,0.0026306496,0.029081395,0.0018288748,0.046389017,0.025463682,-0.034935288,-0.038614083,0.056955043,0.022862835,0.016672365,0.012156395,0.00052227324,0.07397658,0.07829366,-0.030345429,-0.048168268,0.00783793,-0.008665084,0.06554335,-0.050214767,0.10005193,-0.086664036,-0.013772302,-0.036002412,0.014393767,-0.051057022,-0.0021794133,0.021822572,0.06745038,0.029554678,0.005126851,-0.056173034,0.05175359,0.019508129,0.0693397,-0.0775318,0.0035067482,0.110792205,-0.08097167,-0.024059404,0.036572684,0.019999446,0.056632943,0.06497997,0.014531311,-0.009436934,0.06070098,0.0002351235,-0.0004133446,0.00583726,-0.09065386,-0.0029974508,0.010633727,0.046971552,0.04826066,0.038615108,0.07335732,-0.017660586,-0.0039071385,0.08077483,0.013747269,0.022507094,0.08208779,-0.03768873,-0.0553276,-0.022419313,0.07438874,-0.02185824,0.039554626,0.09593375,0.0316886,-0.010224801,0.0069302213,-0.049951132,-0.051425897,0.029438993,0.04666805,-0.06006393,-0.0072112717,-0.022725126,0.072798334,-0.005010056,-0.042327948,0.0067757266,-3.1522347e-08,0.04679926,-0.038079277,0.052012134,-0.01359722,0.07635541,0.053414464,-0.024495378,-0.028523076,-0.008812011,-0.003891482,-0.030447004,0.12452705,0.01851208,0.0008106655,0.057048544,-0.04646439,-0.07227103,-0.000417696,-0.03803245,-0.033675924,-0.06659158,0.022865493,-0.102302186,0.031430557,-0.050296914,-0.001868612,0.025503842,-0.07389555,0.07596976,-0.030987374,-0.033362985,-0.0115203755,0.050322987,-0.05527221,-0.109753616,0.06690718,0.005356782,-0.048136555,-0.07962326,0.051460624,-0.0073594656,-0.08551654,-0.045625314,-0.037945792,0.024202462,-0.0021073879,0.035293702,-0.016353229,-0.038915366,-0.05622201,0.06493014,-0.03746925,0.042500023,-0.02225122,-0.07922294,0.036236063,-0.023141224,-0.07293776,-0.053267155,-0.07686332,0.020328421,0.042621564,0.10183293,0.021022087 +1.14.13.3,A flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.14.13.4,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.14.13.5,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.14.13.6,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.14.13.7,"A flavoprotein (FAD). The enzyme from the fungus Trichosporon cutaneum has a broad substrate specificity, and has been reported to catalyse the hydroxylation of a variety of substituted phenols, such as fluoro-, chloro-, amino- and methyl-phenols and also dihydroxybenzenes. cf. EC 1.14.14.20, phenol 2-monooxygenase (FADH2).",384,1.0,-0.07247241,-0.0682286,-0.1349071,-0.043933716,0.11959547,0.03277448,-0.0500132,0.046757452,0.02689458,-0.039701696,0.06954572,-0.051506754,-0.13404049,-0.007128828,-0.088377364,0.024129126,-0.053805362,0.033950545,-0.029044809,-0.05523169,0.03229464,0.0008357468,0.0071653365,0.013503164,-0.024355223,0.0028484392,0.058624566,-0.038880453,-0.04585161,-0.039199654,0.06246154,0.047051497,0.0042557465,-0.021288512,-0.06667751,0.07112035,0.017728914,-0.027362136,0.053354274,0.030295737,-0.010653841,-0.054297373,0.007790132,-0.040209845,0.012705067,-0.030052362,-0.0091225775,0.09671531,0.052002706,0.03383029,-0.058793746,-0.0030254996,-0.053807225,0.028680347,0.032438062,0.079008356,-0.011597757,-0.030415934,-0.050870594,0.094331235,-0.024352469,-0.04498881,-0.011917029,0.04049423,-0.038577054,-0.05062709,-0.043130245,-0.045913655,0.0383765,-0.034581065,-0.037884798,-0.035472617,-0.008263595,-0.034187485,-0.022646118,0.094958715,-0.03731916,0.010223446,0.055161335,-0.04785653,0.060781144,-0.024498258,0.09897111,0.06274551,0.073899366,-0.043780413,-0.0512253,0.0028026805,0.010345418,0.086136326,0.07729002,0.06944797,0.046764724,0.036762107,-0.082599334,0.12992379,0.07763923,-0.016926445,-0.045911986,-0.019891785,-0.018595967,-0.020230355,0.019345129,-0.060332734,-0.042730287,-0.047552362,-0.03451427,0.094016135,0.026544906,-0.041839313,0.0015056052,0.01232442,0.004916125,-0.09524028,0.018075336,0.028316792,0.021748502,-0.09970467,-0.037323527,-0.017423937,-0.047486793,0.048946172,-0.006545581,0.024608027,0.033049293,0.022644505,-0.043788847,2.1568804e-33,0.09709995,0.054471403,-0.07742152,-0.021647548,0.006377922,0.0029282228,-0.04434387,0.025877621,-0.033063453,-0.0702681,-0.0039543714,-0.01897196,-0.031976167,-0.035221163,0.040965725,-0.008831468,-0.010177795,-0.028421635,0.08610267,-0.015135448,0.043376416,0.011154103,-0.03857251,0.029680472,0.056912854,0.029776786,-0.06621355,-0.029762452,0.018485386,0.042430583,-0.047332432,-0.08020463,-0.03753485,0.009017212,-0.01545135,0.02128676,-0.06924752,-0.076678835,-0.10933642,0.04290015,0.013721391,-0.030762093,-0.007853186,-0.021762662,0.024754595,-0.05474189,-0.055996455,0.110790536,0.024306122,0.097542204,0.029118251,0.0064921817,0.12159169,0.081422456,-0.058844257,0.025223043,-0.032242253,-0.005984401,0.06994934,0.0020956774,-0.030570248,0.09754293,-0.013710403,0.07747764,-0.061268464,-0.03406362,-0.030569248,-0.052527588,0.020938,0.08890288,0.033891708,0.0076176194,0.026397713,0.01407729,0.07644312,-0.044441655,-0.04129714,-0.049205713,0.0095428545,0.03561469,0.021780584,0.0044027963,0.021562269,-0.020906875,-0.047436047,0.07036873,-0.028258499,-0.0047177584,0.01469594,-0.040645625,0.015973678,-0.078957684,0.011171033,0.0026963875,0.059744265,-1.5418449e-33,0.049392384,-0.10303434,-0.009979159,-0.02040328,0.015228366,0.041408073,0.0057774154,-0.061759084,-0.011571945,-0.029283293,0.028956654,-0.04028796,-0.033240955,-0.0283437,0.0017600356,0.005225439,0.0038818282,0.032966264,0.06866595,-0.018753057,-0.011418709,0.016080776,0.051300723,0.10571869,0.041361917,-0.012167562,0.018485736,-0.031891048,0.02809871,0.08597138,-0.05560328,0.039809357,-0.028064657,0.042267073,0.0031001882,0.05978522,-0.049755804,0.06525573,0.018354628,0.052607574,-0.021543363,-0.020538231,-0.003605753,0.03249991,0.009725585,0.09376553,-0.053391173,0.039200544,0.03142068,-0.0705755,0.0021854606,0.08441879,-0.016065681,0.08003521,0.04546715,0.017006567,0.011501862,-0.019403929,0.0006688711,-0.034182042,-0.05738196,-0.11051944,-0.027838971,-0.00893238,0.12717168,0.08435677,-0.012692314,0.11689577,-0.009474973,-0.03584916,0.10630978,-0.014378824,0.057027742,0.10692627,0.0041002594,-0.04660002,0.008988383,0.041378636,-0.011000497,0.06643152,0.08986445,-0.027523154,0.029241743,-0.033965692,-0.08999037,-0.15944381,0.027216284,0.049660984,-0.055074718,0.0034097321,0.006617513,0.052642267,-0.042294696,-0.016532099,0.10009176,-3.9929514e-08,0.020569261,-0.04751218,0.030929448,-0.04995453,0.07522184,0.035989724,0.020878622,-0.008515195,0.00843905,-0.023389941,-0.062258527,0.07171866,0.034902595,0.081994995,0.025215922,-0.017239979,0.0065215244,0.02150129,-0.009378528,0.015186514,-0.032913364,0.0147207575,-0.110365495,-0.027997667,-0.06006105,-0.018172659,-0.022524739,-0.07580785,0.064604625,0.031526864,-0.061514486,0.031360436,0.007343728,0.0086013395,-0.08017713,0.017609335,0.011584476,-0.050467253,-0.07221869,0.020183327,-0.07609155,-0.050176855,-0.01842946,-0.010967523,0.0016850819,-0.05376045,0.049718864,0.025287975,0.032540947,0.009444696,0.050144434,-0.01754935,0.0613079,-0.04037346,-0.08872672,-0.051107794,0.018209528,-0.059462294,-0.056764625,-0.11249035,-0.015969088,0.031804442,0.14768171,0.034432534 +1.14.13.8,"A flavoprotein. A broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines [3,4]. This enzyme is distinct from other monooxygenases in that the enzyme forms a relatively stable hydroperoxy flavin intermediate [4,5]. This microsomal enzyme generally converts nucleophilic heteroatom-containing chemicals and drugs into harmless, readily excreted metabolites. For example, N-oxygenation is largely responsible for the detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 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+1.14.13.9,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.14.13.10,A flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.14.13.11,"NADH also acts, more slowly. Involves a heme-thiolate protein (P-450).",384,1.0,-0.017124003,-0.05352965,-0.02414724,0.0028854918,0.0452867,0.03302353,-0.048516106,0.0914834,0.0696765,0.036117066,0.009643087,0.03327089,-0.04903232,0.096752696,0.014840551,0.006144822,-0.0072119236,-0.027674157,-0.0049149366,-0.063065186,0.023156175,0.060100865,0.034453847,-0.03236163,0.026749017,-0.013618313,-0.011487718,0.033682372,0.018425997,-0.07376304,-0.0928336,0.051859483,-0.061594248,-0.0038950238,-0.008625298,0.12812404,-0.051450413,0.019299189,-0.0006670695,-0.016880237,0.1033452,-0.06604106,-0.08388585,-0.010504099,0.00693481,0.002841911,-0.021117272,0.08909525,0.051316697,0.005203257,-0.059682257,-0.03120263,-0.035375997,0.045835707,0.027689772,-0.032173973,-0.00422414,0.060449287,-0.007180436,-0.09163766,-0.08817547,-0.009627249,-0.035056386,0.035374936,0.08203759,-0.051160935,0.10317903,-0.02322011,-0.06501183,0.011662104,-0.027607637,0.041468706,0.006285974,0.038084954,-0.034278728,-0.016392028,-0.070013866,-0.071468994,0.01479617,0.02408041,0.027161984,0.08463376,-0.043740857,0.045710206,0.0014512211,0.048808195,0.00059913966,0.014713287,-0.13367915,-0.05837693,-0.004877131,-0.020695955,-0.07677695,0.0325195,-0.106374644,-0.00684979,0.05191372,-0.00021822135,-0.03587429,-0.031629656,-0.03544261,0.083582036,0.007635567,-0.034126304,-0.047854394,0.04221797,-0.018116068,0.07198486,-0.04202479,0.04288868,-0.0016845082,-0.028501775,0.052453607,0.009568883,-0.059060596,0.108204365,-0.03645637,0.040584955,-0.07599,-0.060707744,-0.00894611,-0.012468969,-0.0058079883,0.005499005,-0.019756177,0.016369414,-0.050144088,-2.2173723e-33,0.10908381,-0.048957072,0.023187988,-0.004858008,0.0063851043,0.006426589,-0.109788895,0.057899,0.017781368,0.010664192,0.010773377,-0.14755316,0.060748067,-0.039364073,-0.0376044,-0.07456629,-0.05693948,0.000514671,-0.05816247,-0.017670073,0.005427064,0.068109706,0.009812495,0.029829048,0.017012684,-0.007389479,-0.039340556,0.02630625,-0.024663871,-0.008580908,0.029432153,-0.010874225,-0.072311774,-0.048339333,0.040641766,0.01549586,0.011843764,-0.039819457,0.019104058,0.004770701,-0.060388576,0.021244684,-0.041022204,-0.037280586,0.03296128,-0.11743151,-0.06197507,0.03960778,-0.015743012,0.08743725,0.10412204,-0.06444473,0.12551408,-0.013244125,-0.051252443,-0.0049184305,0.016931498,-0.050215945,-0.06787319,0.116627105,0.086898185,-0.008252858,-0.06642337,0.09961121,-0.055050116,0.033953752,-0.13121745,-0.055397853,0.031101337,0.08602604,0.021368435,0.020037636,0.08229733,-0.047492243,0.03529857,-0.07546705,0.008661101,0.036567762,0.03611692,-0.02796617,0.041026782,-0.08289488,-0.055193234,0.006658737,-0.040089563,0.044505302,0.06595021,-0.027999604,-0.0068741436,0.0043799877,0.06710125,-0.049870446,5.547979e-07,-0.04211916,0.045951318,1.4370003e-34,0.11647247,-0.054400887,0.058052104,-0.030203616,0.032527078,0.11627811,0.051748846,0.008221157,-0.05707771,-0.096068785,0.075575046,0.024313204,-0.047263026,0.019447038,0.055361513,0.024361365,-0.0028744692,0.00039033935,0.02184556,0.031308647,0.0033229769,0.09027892,0.037916843,-0.00801708,0.0937292,-0.04701255,-0.053771626,0.049091734,0.01841091,0.049479097,-0.027009763,0.008396588,-0.15041614,-0.06717849,-0.0033790295,0.06864256,-0.034832373,0.0035292916,-0.02475526,-0.017930811,-0.027758583,-0.009182099,0.035312302,0.026951045,0.048947252,0.08757988,-0.05515312,-0.05608095,-0.026101276,-0.013435082,0.04511829,0.040401243,-0.05489254,0.07250664,0.014077391,0.02633699,-0.06044379,-0.0116665885,0.0030617984,-0.026053237,-0.017545415,-0.029678242,-0.033907305,0.018364506,0.06822539,-0.016815094,-0.013577412,-0.034290735,0.1324112,-0.031539917,0.036789823,0.060739584,0.032237124,0.058257997,-0.020990644,-0.06973884,-0.03959296,-0.008450323,-0.01154564,-0.032278687,-0.057644714,0.07295834,-0.05607073,-0.06319711,-0.06895141,0.024204742,-0.012403714,-0.0063884356,-0.0025265382,0.054909017,-0.012061945,0.04037471,0.038340736,0.041901875,-0.000821521,-2.4947916e-08,0.036903188,-0.08709774,0.034380052,-0.014222122,-0.0007567598,0.038718466,0.070661604,0.0395803,0.04121164,-0.01413138,0.025718128,0.120459944,0.11558654,0.025247835,0.0612975,-0.007294922,-0.028603677,-0.007159973,-0.017246673,-0.053895976,-0.09289709,-0.015095699,-0.05729715,0.031276718,-0.004111015,-0.022501124,-0.015799267,0.0101432195,0.0011016857,-0.122185044,0.022059502,0.029851414,0.021948677,-0.026930641,0.0012717313,0.054811865,0.005385598,0.0650876,-0.005504237,0.032563765,-0.036006708,-0.07220317,-0.06085776,-0.005334257,0.012872958,-0.026959574,0.07123585,-0.03236456,-0.009693602,-0.047041986,0.06348638,0.029060163,-0.037352026,-0.055116568,-0.06748557,0.015972568,-0.023032708,-0.07011087,0.037361678,-0.068071894,0.03133682,-0.0013218878,0.1111877,-0.011708414 +1.14.13.12,Requires Fe2+ and tetrahydropteridine.,384,1.0,-0.0215312,-0.060219575,-0.07689704,0.07608402,0.07794702,-0.03385227,0.020819552,0.0044568772,-0.026287567,-0.06828613,0.047161475,-0.04236631,-0.099065594,0.08225392,-0.0062263957,-0.03741537,-0.017357184,-0.020311575,0.043934334,0.024102328,0.018667223,-0.059278715,0.04128743,-0.03798186,-0.0754228,0.07166543,0.019489042,-0.020731337,-0.010028366,-0.096392006,0.017197857,0.07086369,-0.03268262,-0.07826937,-0.02764762,0.019638581,-0.039089814,0.038128745,-0.012107272,-0.01081897,-0.038657524,-0.0989168,0.02251333,0.026245233,-0.01234141,-0.07823495,0.12044084,0.031196611,0.055854745,0.057619892,-0.024609357,0.06608456,0.014422389,0.07051894,0.022270331,-0.04461018,0.003118405,0.0036248805,-0.014259558,-0.011790648,0.012200728,-0.021281393,-0.06656097,0.021554189,0.017415298,0.0008666915,0.0027364842,-0.036938474,-0.041003086,0.027199658,-0.009917337,0.019399337,-0.038894672,0.033692423,-0.03203601,0.04045668,0.083647765,-0.0728706,0.11439302,0.108294696,-0.08453597,-0.036538165,-0.026737683,0.06606071,0.097578555,0.08508208,-0.019303745,-0.030857345,-0.12128197,-0.0022858693,0.04197987,0.064518385,0.013762677,0.028256651,-0.021818822,0.044548046,0.004664437,-0.042422015,-0.058784932,0.0130719105,-0.08001685,0.010120534,-0.044848856,0.031092351,-0.04527179,-0.060813826,0.0015655346,0.038735937,-0.008454724,-0.013930608,0.04293191,-0.033352867,0.04111937,0.013944682,-0.023327561,0.03824413,0.0020761483,-0.03267485,0.04202119,0.022023844,0.011328517,0.06411937,-0.05522999,0.030718587,-0.056826394,-0.014807944,-0.024669578,3.4431265e-33,0.06540839,0.08560449,0.0020818324,0.053686947,-0.01980662,0.03198834,-0.08069921,-0.046605837,-0.020568881,0.01097947,-0.07009937,-0.0707562,0.009935703,-0.01869793,0.011623575,-0.11577579,-0.007928862,-0.026428703,0.06237839,-0.08116445,0.027030434,0.082692735,-0.03265701,0.0012771699,0.066551924,0.104940504,-0.026566995,-0.046405744,0.06397913,0.01950449,0.050557658,-0.0041691028,-0.03161113,0.024587922,0.007847053,0.017052822,-0.09457536,-0.017141571,-0.02560202,-0.012021446,0.025875982,0.061997924,-0.038611602,-0.022943564,0.058075473,-0.13634068,0.0131182,0.14753793,0.02071396,0.0608507,0.0032817593,0.027907262,0.015996128,-0.001022794,-0.036912367,0.009013071,0.020803778,0.00865898,0.08184842,0.0351618,-0.018594058,0.08170617,0.041614816,0.015342996,0.04982562,-0.02224072,-0.04166927,0.037845597,-0.013118391,-0.0020766568,-0.098306894,0.06321896,0.124870256,-0.0048411484,0.06567672,-0.044158198,-0.061071813,-0.09343113,0.10907204,-0.052464,-0.013331291,-0.07273473,0.045859773,0.0067599025,-0.06454222,-0.025585627,-0.07183517,0.02454148,0.026968012,0.008883434,0.018798783,-0.09193249,-0.024871068,-0.08793225,0.04410693,-3.718338e-33,-0.022118188,-0.0686958,0.01980126,0.01987593,0.046335466,0.03710386,0.0027560676,-0.16035031,0.038530562,0.03362027,0.021584522,0.013445225,-0.0013102889,-0.050088137,0.015442507,0.07901982,-0.045402538,-0.006969601,0.055318426,-0.04908533,0.0045725172,0.058362324,-0.016666058,0.06828678,-0.0011870213,0.022621626,0.008225866,-0.006839891,0.043392178,0.056759164,-0.0015352301,-0.0015683937,-0.078238934,-0.08666536,-0.047773484,-0.031979464,0.029406676,0.0016375745,-0.009239487,-0.0016674232,-0.003995051,-0.004236565,0.011616582,0.13652837,-0.029208913,0.0020330392,-0.006856821,-0.01745258,0.03733754,0.046553884,-0.008572027,-0.057404272,-0.110703826,-0.014158506,0.042787004,-0.03325814,0.09771706,-0.023503209,-0.05299142,0.04018979,0.027823808,-0.038575605,0.03051823,-0.076300085,0.04555307,-0.030588537,-0.034881383,0.16639242,0.0832406,-0.00025391293,0.07770367,0.056973517,0.118612766,-0.06665391,0.047742225,-0.06343895,-0.00826176,0.029415594,0.042676143,-0.00860821,-0.008020353,-0.0078019453,-0.017796068,-0.03479797,0.04049019,-0.09521839,0.032842014,-0.0028469795,-0.03373332,0.03192238,-0.021602403,0.012152774,0.075747974,0.044495624,-0.038176615,-2.2392625e-08,-0.02275845,-0.013980863,0.028668156,-0.047577824,0.015888384,0.037704077,0.090114534,-0.005332051,-0.03666132,-0.102620095,0.048929583,0.03170106,0.09027229,0.047651056,0.116820045,-0.0720361,0.01529279,0.031650092,-0.06864094,-0.066115044,-0.113158934,-0.033042148,-0.07172253,-0.015786473,0.008730642,-0.0071212733,0.0211034,-0.02071903,0.07889,0.02950912,-0.055219132,0.00296922,-0.06249807,-0.04565449,-0.08208776,0.036011532,0.007139519,-0.0211808,-0.027062051,-0.0035373007,0.0041728066,0.055116992,-0.06091343,-0.0023231949,-0.011334438,-0.043732524,-0.057652976,-0.0027683014,-0.022235982,0.038369734,-0.0021925776,-0.011821459,0.016456015,0.0040084734,-0.002581835,0.07033364,-0.0065750456,0.008455065,0.08947287,-0.07297154,0.026592106,-0.027060872,0.0592633,-0.011905602 +1.14.13.15,"The enzyme requires ferredoxin and ferredoxin reductase. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-en-3beta,7alpha-diol, 7alpha-hydroxycholest-4-en-3-one, and 5beta-cholestane-3alpha,7alpha-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25.",384,1.0,-0.02592706,-0.07629132,-0.09560033,-0.030762607,-0.007794702,-0.003233306,-0.095649354,0.011612003,-0.015881862,-0.07588925,0.0012679584,0.015025038,-0.070364654,-0.025858453,-0.00037607708,0.023740932,-0.06735305,0.02090348,0.012873814,-0.056650806,0.041161824,-0.06381651,0.00930565,-0.02281008,-0.03506925,0.008171316,0.095481366,0.031037094,-0.060527816,-0.1343331,-0.020559419,-0.050531123,0.053747,-0.06905345,-0.07338887,0.07044347,-0.0368458,-0.024701914,-0.012250674,0.032444395,0.030707069,-0.020036869,-0.01467292,-0.07819693,-0.006686512,-0.11599174,-0.02627816,0.009768783,0.05849985,0.046924803,-0.01668267,-0.054671347,0.00046959618,0.0365401,0.00090968865,0.037351333,-0.04717236,-0.058137488,-0.010641856,-0.014344472,-0.0007498052,-0.0023024292,-0.02248274,-0.034383565,-0.06810803,-0.07098784,0.018435583,-0.05435769,-0.018305292,-0.037960205,-0.042032205,-0.04984776,-0.06720594,0.0077341227,-0.024614478,0.024260718,-0.047277153,-0.06404206,0.067706965,-0.049209256,0.017890722,-0.017063905,-0.020215122,0.13862346,0.11731404,0.03443091,-0.07147306,0.009995955,-0.013511642,0.071865365,0.05160256,0.041504942,0.003971625,0.020960478,0.010150874,0.028121114,0.028890975,0.033923108,-0.030088138,-0.03664015,0.030957747,0.06004435,-0.03514134,-0.047145378,-0.007485887,0.0028337229,0.0070444266,0.07797934,-0.018285103,-0.04337218,0.0009379269,-0.04447537,0.14494511,-0.044438455,-0.05506453,0.14762224,-0.0190914,-0.07567697,-0.06311939,0.023274342,0.04407895,0.054443806,0.02569751,0.04477564,0.003804166,0.01899173,-0.019146645,4.5146047e-33,0.08330833,0.009485363,-0.010091562,0.054988984,-0.027393008,0.07083546,-0.03794554,0.024461761,-0.0052927993,-0.06305937,0.03337374,-0.04646181,0.020400468,-0.039583623,-0.028460516,-0.007967655,0.06065302,0.023911983,0.039996237,-0.030068062,0.012028211,0.04878116,-0.08325732,-0.035968315,-0.0060594045,0.03919782,-0.022514224,0.032245245,0.019016273,0.026749836,0.0032605035,-0.07168676,-0.06438848,0.034757033,0.06884991,0.057260796,-0.046682887,-0.005512489,-0.07560787,0.11135425,0.045758136,-0.005738684,-0.022419995,-0.053901665,0.050600592,-0.014475004,-0.021469668,0.09926026,0.12013573,0.13141873,0.03912346,0.027397858,0.054734282,0.026457584,-0.021705927,0.060048237,-0.008629495,0.035042748,0.03467742,0.042830378,0.012854703,0.10333638,-0.045081284,0.044871394,-0.001421819,0.010667921,-0.05903629,-0.081047796,-0.11717511,0.093600206,-0.031355735,0.014853857,0.015428523,0.0068105552,0.03557127,0.024381444,-0.03587992,0.0466766,0.025407515,-0.06709147,-0.015550014,-0.029835211,-0.028628184,-0.04930963,-0.038567718,0.040394377,-0.03580932,-0.059128735,-0.029298697,0.018987183,0.0015279718,-0.047728106,-0.098294206,0.01012675,0.038759485,-5.3363373e-33,0.010578772,-0.09554121,0.05815769,-0.06722595,-0.0436902,0.06596508,0.034553453,-0.045745645,0.09778047,0.0065752915,0.025697086,0.0057755234,0.011757056,-0.049879313,0.050762247,0.07393403,-0.049043864,-0.0059735174,-0.00034317147,-0.02293425,-0.038116183,0.11594291,0.027312977,0.1929398,0.037157174,0.03954455,0.024074527,-0.0134115,0.13578625,0.07941324,0.0068651447,-0.06053884,-0.015353661,-0.014759968,-0.10845308,0.04406362,-0.06944161,0.022472873,0.047855884,0.01890712,-0.03041869,-0.03863435,0.029413305,-0.02803393,0.018523889,0.022002522,-0.036247756,0.04320053,0.035152413,-0.03646796,0.015776118,0.026959207,-0.015749678,0.058077883,0.05068942,0.05860512,0.06190719,0.012814269,0.065069064,-0.094401896,-0.027295407,0.03952542,0.0524774,-0.020575235,-0.02634569,0.051545054,0.007843956,-0.04199775,0.012585152,-0.010753081,0.0031127254,0.037098024,0.03453222,0.059297465,0.013756754,0.007360006,-0.021713082,-0.013903956,-0.032671764,-0.03129677,-0.024314905,-0.023045061,0.059756424,-0.071297936,-0.04355511,-0.08152157,-0.03296811,0.054494437,0.06273513,0.0054678055,0.0145324115,-0.00037140047,-0.07046934,-0.008132393,0.017656328,-4.3197232e-08,0.025537588,-0.10934951,0.02840894,-0.06348906,-0.07953574,0.0049040243,0.065972514,-0.046007674,0.05755959,-0.026669156,0.0014071603,0.17610008,0.02517568,-0.02322739,0.023055378,0.044059638,-0.0070053944,0.010929794,-0.014856294,-0.06876116,-0.07081979,-0.046841815,-0.036690995,0.025061278,0.020018244,-0.025941364,0.0013882011,0.02223664,0.029319178,-0.027213836,0.04969461,0.0054939324,-0.016308788,-0.0113909645,-0.022024117,0.04195012,-0.03205052,-0.013320498,-0.020024562,0.0734748,-0.014748195,-0.049140543,-0.04634436,-0.017419254,-0.024182085,-0.022800216,-0.007154466,0.03395881,0.022213012,0.022435414,-0.04757032,-0.02786269,0.015148217,-0.030834885,-0.057765957,0.03648195,0.033034008,-0.10873176,-0.007080351,-0.04194424,0.007706876,0.04958199,0.21991771,0.009951815 +1.14.13.17,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.14.13.18,A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming 2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming hydroquinone and glycolate).,384,1.0,-0.042041834,-0.110409096,-0.036766406,0.022175381,0.07408749,0.014223677,0.010879281,0.052209325,0.027329572,-0.06106531,-6.584826e-06,0.06467868,-0.07769554,-0.01858516,-0.080862425,0.027617048,-0.05745538,-0.02039867,-0.06745101,-0.0034931812,0.019713158,-0.03686407,0.032572508,-0.018022837,0.022829834,-0.012146975,0.024830198,-0.05898753,0.0050031645,0.0329159,0.09515317,0.07889056,0.025108429,0.009559513,-0.08521902,0.03810736,0.083916344,-0.00056688057,-0.012835723,0.024043825,0.068525545,-0.07824608,0.06526633,-0.0023646266,0.08732651,0.014663579,0.0051615876,0.07090616,-0.011405698,0.090097226,-0.01997169,-0.06443626,-0.11558593,0.07923422,-0.006733574,0.064387284,-0.02520391,-0.04783647,0.0134312445,0.04491441,-0.027505398,-0.036493905,0.04911779,0.021671915,0.04864933,-0.027657015,-0.046645243,-0.022686336,0.043516926,-0.03541954,0.03547723,-0.008345899,-0.041118227,0.0007312852,0.0015477473,0.036966395,-0.10228283,-0.033700027,0.07267957,-0.028311763,0.077137865,0.008648989,0.11038509,0.06485952,0.036276784,-0.056204274,-0.016691757,-0.03795296,-0.049946677,0.04887079,-0.037389062,0.0070443987,-0.008136647,0.04072298,-0.07793374,0.053616215,0.07342084,-0.10567024,-0.01976413,-0.0060134404,-0.063936785,0.00939293,0.03403109,-0.0007313301,-0.063746616,-0.05400643,-0.05676649,0.04388896,-0.038167547,-0.03959733,-0.020167418,-0.029586479,0.011113198,-0.05335865,-0.010984473,0.007488247,-0.018572547,-0.05438634,-0.04366543,-0.054726604,-0.08866802,0.10428891,0.07075734,0.03012798,0.0055537256,-0.017140714,-0.07281322,2.8082018e-33,0.07361161,4.3955537e-05,-0.025398834,0.018869309,0.02294025,0.009822886,-0.03988759,0.0007357633,0.024668718,-0.030677082,0.0038305186,-0.0022780686,-0.010598704,0.020497845,0.023077065,0.0169163,-0.03858311,-0.038823377,0.08992626,-0.13091621,0.040524382,0.06605246,-0.019880217,0.008000538,-0.011895008,-0.021962676,-0.06739098,0.047629975,0.039865226,0.025859468,-0.014113856,-0.0508037,-0.051696952,-0.036239192,-0.0341588,0.059928972,-0.1051645,-0.1047706,-0.06883158,0.0764497,0.0042618746,-0.042100582,-0.0051605687,-0.0304683,0.0067232023,-0.006201511,-0.05253844,0.074783385,0.011243454,0.11092513,0.039041903,-0.046960216,0.11273919,0.06416817,-0.10458716,-0.020624373,-0.044539195,-0.04798891,-0.0054436773,-0.024927078,0.026207877,0.049435418,-0.019754782,0.08241069,-0.09212585,-0.01412163,-0.025740087,-0.027510293,0.0055239643,0.10191733,0.03366222,0.003202077,0.09011269,-0.008249839,0.08730501,-0.050494578,-0.04154042,-0.06485936,-0.05199664,0.023837706,-0.053768665,-0.033915497,0.001510982,0.014771491,-0.041986693,0.062407363,-0.0038890855,-0.041307732,0.028758435,-0.03702829,0.011832494,-0.03373434,0.0017610125,0.009505335,0.047390603,-2.8729073e-33,0.014133578,-0.09986451,0.028635113,0.060151942,0.03399213,-0.022629583,0.06584367,-0.0157582,0.054318532,-0.02155586,0.034464307,-0.044821657,-0.021285811,0.00465773,0.028927995,0.020109726,-0.04952763,0.009225454,0.029689537,0.03576363,-0.04775405,-0.02559037,0.0233833,0.11506882,0.05625462,0.0100241825,0.049616944,-0.0962769,-0.004124756,0.09347439,-0.033879977,0.03853614,-0.060520135,-0.009272857,-0.073050685,0.008864047,-0.03240441,-0.019816514,-0.046428088,-0.013985857,0.017219879,0.011944615,0.016856724,0.07835568,0.07114736,0.06701943,-0.029236477,0.08030407,0.03972162,-0.021629434,-0.001257952,0.022392359,-0.0042673294,0.093488984,0.071150094,0.050822977,0.062153257,0.030030793,-0.028876483,-0.02285015,-0.012436294,-0.105987675,0.0075283796,-0.035545565,0.104882896,0.032097146,0.012406877,0.09406201,0.012340482,0.04948324,0.1289509,0.016200569,0.017007535,0.08428578,0.058402006,-0.02384849,-0.0068872403,0.04651307,-0.034824822,0.031264715,0.02869126,-0.0039681974,0.026902486,0.029982153,-0.09906209,-0.120846316,-0.025719464,0.09862022,0.0008332888,0.04399343,-0.02827017,0.078277886,-0.020842992,-0.06157009,0.04761602,-3.4271196e-08,-0.031226076,-0.05309174,0.027343549,-0.02482354,0.05051441,0.0140026575,-0.03680085,0.0054191463,0.015588833,-0.06896429,-0.054424252,0.109703295,-0.029839411,-0.051795077,0.04119941,-0.059738446,0.013380872,0.047316063,-0.056572653,-0.030550461,-0.09877887,0.035292763,-0.056575317,0.04206987,-0.07132278,-0.034457076,0.016189137,0.0055264523,0.03689735,-0.0063393046,0.05503018,0.04381515,0.009249293,-0.06750341,-0.14315882,0.060514234,0.07349114,-0.05113154,-0.018305881,0.013661941,-0.10325347,-0.02929742,-0.0039363354,-0.049373616,-0.0028730456,-0.018486623,0.025943741,-0.010267689,-0.020512199,0.004946002,-0.0034149396,-0.015773054,0.019679043,-0.003122485,-0.06149798,-0.036723677,-0.032178875,-0.055848986,-0.013680619,-0.106488,-0.013700659,0.068577096,0.14472117,0.011139652 +1.14.13.19,"A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercetin or mollisacidin.",384,0.99999994,-0.02088918,-0.066961884,-0.14188169,0.068630666,-0.0030238864,0.004868121,0.054041468,0.02157399,0.033658154,-0.09439607,0.034378257,0.008543879,-0.052965906,0.009786621,-0.09110163,0.026597306,-0.02624779,0.0557909,-0.076435275,0.03990096,-0.0049512805,-0.02586173,0.039575215,-0.006561459,-0.01937204,0.016901411,-0.038341317,-0.042410824,-0.035188463,-0.045929857,0.035449974,0.097573556,0.018420944,0.024427345,-0.06170361,0.029226845,-0.019071491,0.022549838,0.038395546,0.037371844,0.008221511,-0.059132803,0.004772263,-0.019528886,0.07523966,-0.030147906,-0.009367269,0.083311416,-0.018300194,0.10474872,-0.09961796,-0.0146988155,-0.12118294,0.065755084,0.052121866,0.0139773,-0.014096397,-0.008346972,-0.055334263,0.06594492,-0.024883365,0.03352507,0.0204938,0.042880714,0.042994637,-0.091036186,-0.030222937,0.0024422663,0.060514413,-0.06542034,0.016103394,-0.026767354,-0.027802212,0.043697294,-0.015038804,0.065181695,-0.0029702443,0.047465526,0.053055294,0.046870217,0.05580578,-0.010443104,-0.007822691,0.041790046,0.074514695,-0.008403533,-0.079220854,-0.012779755,0.023707949,0.1296638,-0.022177074,0.024978384,0.024655016,-0.025144095,-0.012304903,0.021533316,0.018298814,-0.052297153,-0.07298001,0.024293104,-0.060224928,-0.091492385,0.015996166,-0.024197634,-0.056659013,-0.030662704,0.014251171,-0.034509614,0.024667671,-0.08178885,-0.020265028,-0.049623415,0.035238236,-0.12028741,0.032472193,0.060431637,-0.011363619,0.0089898,-0.018995166,0.012759071,-0.041042056,0.09456814,0.034259014,0.042531352,-0.044186275,0.008170555,-0.018297201,3.9753305e-33,0.10097012,0.010014838,0.007584458,0.053635515,0.05495513,-0.023576178,-0.0045823106,-0.03420846,0.014018414,-0.049384538,-0.03937014,-0.0062416475,-0.023437891,0.0065344507,0.054682385,-0.024534412,-0.027671339,-0.066365704,0.07311088,-0.06209671,0.044716846,0.078451246,-0.051605046,0.054669883,-0.035909556,0.0037334498,-0.06296987,-0.005759027,-0.02203365,0.03704132,-0.01275389,-0.03253197,-0.012878869,0.0038334664,-0.025547443,-0.00084911374,-0.076456085,-0.12261951,-0.06364226,0.0562723,-0.063108474,-0.06638107,-0.03956849,0.06133065,0.019059002,0.018317394,-0.05966123,0.07811493,0.019030828,0.052192822,0.04586824,-0.041565157,0.13617213,0.043609165,-0.08619871,0.020033514,0.010397943,0.019177174,0.021092527,0.044741895,-0.034468934,0.032502677,-0.017660165,-0.031202404,-0.0841815,-0.012846336,-0.04206343,-0.08007389,0.075417355,0.00064411847,0.052089166,0.016927741,0.06572112,0.046422187,0.13389166,-0.0013876385,-0.048523966,-0.01656686,-0.017741373,0.00025042257,-0.022917023,-0.06353608,-0.023209754,0.008486534,-0.065219015,0.060744513,0.01891145,-0.040007196,0.0070200525,-0.0065724025,-0.005016163,-0.062920496,0.0056246966,-0.03333921,0.095955685,-3.5012775e-33,-0.008866461,-0.10154684,-0.040552262,0.09785778,-0.016478997,-0.008094079,-0.018521965,-0.08475914,-0.03093598,-0.032836743,-0.056184877,-0.102749676,0.027520947,-0.02516788,-0.037481993,0.027042618,-0.019151378,0.013804736,0.046876166,0.06290283,-0.02831203,-0.025907129,0.021112708,0.08424415,0.048944723,0.028038464,0.05012119,-0.07261631,0.028976187,0.047462005,-0.06740782,-0.009386578,-0.011185053,-0.07889592,-0.04382103,0.040900465,0.0530238,-0.050422918,-0.06700623,-0.023628507,-0.019430112,0.0148254,0.04167168,0.053611368,0.018816477,0.0644459,-0.06363288,0.014154734,0.025332121,0.014117633,0.05192119,0.099706486,-0.034578394,0.098817624,0.021060016,-0.021546101,0.016159687,-0.02223235,0.00088242145,0.025220377,-0.01605463,-0.14838856,-0.011823894,-0.015323735,0.09078798,0.059248444,0.017958779,0.120945625,0.042611625,-0.052361067,0.12237308,-0.057330064,0.11909972,0.06180842,0.037066117,-0.037523407,-0.003749717,0.017438129,-0.015292995,0.0073945513,-0.02807924,-0.056367993,0.020967957,-0.03417912,-0.03323357,-0.09176554,0.052031677,0.0070158704,-0.008750999,0.042739656,-0.014421381,0.03588911,-0.063893266,-0.0382522,0.032748166,-2.8075595e-08,0.00851673,-0.044985257,0.005968753,0.01617698,0.1280176,0.032160103,-0.0143837705,-0.01330466,0.0025182136,-0.042537592,-0.029575491,0.109012425,0.02513931,0.015143618,0.08870034,-0.03457763,0.040496007,0.015759971,0.00059343275,-0.015752394,-0.049356762,0.035280876,-0.08602254,0.000554024,-0.04048593,-0.039170932,-0.06635992,0.021208966,0.09353278,-0.011562202,0.014300542,0.026343517,0.030267946,-0.07301851,-0.15206276,0.06275615,0.014901306,-0.09004419,-0.033116132,0.020877263,-0.09982098,0.018959437,0.040800884,-0.00089223584,-0.04506533,-0.071878076,0.06515671,0.022114111,0.022083655,0.002017283,0.056743585,0.03757826,0.008706608,0.00071955903,-0.050559316,-0.04684194,0.051493,0.004634321,-0.0022945125,-0.056703467,-0.035438478,0.01943778,0.13747694,0.011144116 +1.14.13.20,"A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but more slowly.",384,1.0,-0.04976742,-0.09342382,-0.07345394,0.0024450317,0.09794733,0.057864245,0.026675105,0.06864009,0.116620086,-0.025510052,0.022779666,0.039746284,-0.087097734,0.04180088,-0.04890577,0.039767094,-0.04259494,0.002928519,-0.09714534,-0.021860475,-0.00081832084,-0.02909297,0.031229556,-0.050081406,0.010523536,0.004860938,-0.01981139,-0.043439373,0.02883989,-0.029895866,0.029572785,0.13023373,-0.0078679565,0.008697341,-0.06300908,0.051662058,0.042945553,-0.018953757,-0.016506657,0.02260766,0.032838427,-0.036957003,-0.012327486,0.026547948,0.04052337,0.0035594872,-0.009665001,0.0955437,0.008515866,0.026463108,-0.026476707,-0.044115104,-0.098719396,0.030438835,0.012828198,0.03217222,-0.009024621,-0.01817684,-0.009246544,-0.013060657,-0.04528257,-0.08424247,0.035175793,0.038200222,0.05277928,-0.03493068,0.013853438,-0.051032253,0.027164904,-0.023636831,-0.009024049,0.017363876,-0.03970963,0.039492328,0.042639486,0.009215153,-0.06451419,-0.051844228,0.062082153,-0.027849598,0.077054486,0.013076785,0.04012216,0.041357525,0.07734203,-0.016141051,0.0027170768,-0.032748595,-0.07690482,0.046164103,-0.01765085,0.0014393748,-0.024857575,0.020946259,-0.12465521,0.06622979,0.07692723,-0.100372545,-0.08212003,-0.0010276225,-0.031613294,0.04031278,0.010797898,0.0009518751,-0.055802748,-0.042109895,-0.053081434,0.07541258,-0.08951945,-0.015733773,-0.018293124,-0.04199104,0.028280724,-0.07803554,-0.037167124,0.028699191,-0.011938528,-0.02383393,-0.035939902,-0.036955804,-0.06317386,0.0848976,0.010013342,0.048929706,0.037156112,0.038002517,-0.08033683,1.9214195e-33,0.11509204,-0.007271619,-0.023306778,0.016138062,-0.0029781412,-0.0019021635,-0.056564122,0.024519159,0.046815224,-0.062961236,0.0063362145,-0.046111707,-0.0039810734,-0.029975763,0.08962344,-0.0045148963,-0.049037054,-0.060090672,0.0055021616,-0.10955911,0.027610248,0.0899651,-0.0015772119,0.025367556,0.017878644,-0.0331305,-0.09392285,0.059908547,0.014581706,0.027298039,0.015427571,-0.026389165,-0.059810482,-0.00029468298,-0.016403442,0.055055812,-0.085130565,-0.10379237,-0.052040085,0.044498548,-0.07721856,-0.013372628,-0.038941793,-0.006493586,0.0248327,-0.09511474,-0.06410762,0.072568126,-0.039176706,0.10757892,0.033098042,-0.039018527,0.11675989,0.06425325,-0.062159143,0.022327498,-0.012478783,-0.052879903,-0.04397402,0.03902015,0.045501992,0.035333928,-0.040940292,0.109259024,-0.075217865,-3.1509753e-05,-0.09397377,-0.07149016,0.019688243,0.08103808,0.072131254,0.009769134,0.07573695,-0.007502657,0.0819895,-0.060515355,0.03834638,-0.052215796,-0.027493645,0.013522168,0.0041880244,-0.045953568,-0.025522929,-0.018977873,-0.07206059,0.05641754,0.053939383,-0.07041854,-0.005895693,-0.02772792,0.008457107,-0.046496768,0.036095995,-0.0419153,0.04914771,-1.7668632e-33,0.054546453,-0.102943115,0.0710204,0.048796702,0.051328756,0.03273126,0.026261553,-0.05387561,-0.015146258,-0.053624064,0.03149744,-0.024635972,-0.019353075,0.020305589,0.079128616,0.034232836,-0.01088927,0.015776958,0.055650745,0.06792487,-0.037290778,0.0420112,0.04393152,0.121972196,0.054912135,-0.07106993,0.013157936,-0.04486111,0.015450725,0.044167433,-0.045958187,0.032402284,-0.070190765,-0.012079014,-0.021139817,0.026911948,-0.023182003,-0.026253283,-0.056754313,0.040869333,-0.041998167,-0.015854318,0.017841548,0.00264087,0.054198176,0.061237633,-0.057907194,0.014292395,0.046160206,-0.026227081,0.031972338,0.056791116,-0.012803719,0.1015976,0.08820321,0.020720376,0.009871805,0.012847183,0.010668096,0.022155102,0.0063909795,-0.09473933,-0.011183519,-0.007002361,0.14038047,0.01285668,0.0062045106,0.08279754,0.054452807,0.005375019,0.10926432,0.019692149,0.01953057,0.0822249,0.01820839,-0.11332859,-0.050751623,0.067236304,-0.05526733,0.003101663,-0.018021101,0.020877976,-0.008332047,0.0014648252,-0.14138973,-0.06939014,0.0040046712,0.0014215185,-0.011624436,0.041205462,-0.01344811,0.09045302,0.031891365,-0.005594018,0.027231913,-3.4055475e-08,0.023189642,-0.054644063,0.03187372,-0.028844507,0.074142344,0.01755385,-0.004077519,-0.033539433,0.009102681,-0.039625723,-0.048866216,0.15303206,0.06372009,-0.0046935864,0.056701798,-0.015253606,-0.026346106,-0.027713103,-0.006123617,-0.022194143,-0.067460164,0.05300569,-0.08102381,0.017648378,-0.06035975,-0.013481555,0.024718545,0.012603709,0.047071137,-0.03785642,0.0420345,0.004280352,0.04748592,-0.059278585,-0.09691292,0.06390255,0.046975005,-0.03369473,-0.058035463,0.104296096,-0.05691747,-0.033636708,-0.012892049,0.018510306,-0.014410829,-0.042174228,0.07304559,-0.079013385,-0.02149718,-0.02844739,0.03770143,0.0087516885,-0.009379032,-0.011370354,-0.04686255,0.0007421831,-0.00531846,-0.066048644,2.9419389e-05,-0.089450814,0.016360346,0.055858944,0.071666084,0.04464585 +1.14.13.21,"Acts on a number of flavonoids, including naringenin and dihydrokaempferol. Does not act on 4-coumarate or 4-coumaroyl-CoA.",384,0.99999994,0.024688222,-0.07359713,-0.04293315,-0.01907063,0.041143604,0.06709806,-0.05383523,-0.0057881535,0.032532323,-0.043244265,-0.04783097,-0.072289765,-0.08498583,0.015714202,-0.03616705,0.010403262,-0.029032761,0.0408651,-0.077615,-0.015393097,-0.0057720523,-0.030626338,0.05687937,-0.015228227,0.020529412,0.034768615,0.00388966,-0.0076941405,0.060634613,-0.08001131,0.060988925,0.077672005,-0.06255538,0.043317765,-0.04546488,0.01714851,-0.0625776,-0.07583222,0.02814347,0.040219296,0.11025598,-0.0064767953,-0.020092217,0.014866263,0.03194513,-0.07750101,-0.11896728,0.031275235,0.039012812,0.05927979,-0.06472203,0.01538537,-0.07863453,0.07690011,0.014025999,0.05864536,-0.0865909,-0.023467334,0.024873024,0.10835824,0.08306946,-0.08479651,0.031628788,0.014590866,-0.058471844,0.058448136,-0.000102065474,-0.012525746,0.0075715827,-0.02906049,0.029556679,9.023039e-05,-0.018031625,0.046253145,-0.02736523,0.06923811,-0.04883194,-0.017282225,-0.016739754,-0.06978141,-0.0011093628,0.060468648,0.10787557,0.005046325,0.054042257,-0.040290933,-0.0693071,-0.047045074,0.0092399195,0.07802822,0.0027625319,0.060727566,0.03421008,-0.010590518,-0.05354996,0.0343252,0.032473907,-0.030263597,-0.09344427,0.014748109,-0.05134968,0.023363851,-0.045796093,0.011078436,-0.092995636,-0.0034315484,0.015782299,-0.05321107,-0.065668784,0.05671898,-0.025907492,-0.07128807,0.030323666,-0.06919011,-0.015116171,0.07607913,-0.02770228,-0.056159608,-0.061331335,-0.012741565,-0.007153155,-0.05550672,0.0757077,0.0002991384,-0.010477342,0.01912088,0.043493126,3.0599178e-33,0.06374989,0.011974035,-0.016357686,0.07196271,0.028136019,-0.066440076,-0.05894882,0.033544447,0.026120627,-0.045130983,0.005230544,0.048094235,-0.005243867,0.04955035,0.055399675,0.012324582,0.05980793,-0.08999711,0.024330944,-0.0054719234,0.03908536,0.09793544,-0.077998646,0.04602911,-0.09301736,0.0147446,-0.06282756,0.049619358,0.06576829,0.018692091,-0.037022036,-0.056989297,0.015755545,0.021660443,-0.0045227343,0.041142333,-0.12969777,-0.02274365,-0.05365719,0.052746616,-0.012355068,-0.023809938,-0.072310194,0.0044135503,0.016027933,-0.080000564,-0.053896647,-0.0034644993,-0.045509867,0.05116739,0.06244751,0.036896754,0.08427177,0.08211127,-0.031929705,0.027386451,-0.008816029,-0.0140641695,0.061095666,0.0011504123,0.0031932055,-0.038805217,0.0024278858,0.017593876,0.013375382,0.07659252,-0.04855782,-0.062759794,-0.012780259,0.012164692,0.04480948,-0.00089606975,0.062038664,0.05727887,0.11925674,-0.0021815747,0.008386709,0.0042273696,0.00258521,0.033955697,-0.019944472,-0.008410191,0.078337714,0.068038896,-0.02098556,0.013317721,0.003366884,-0.0397072,0.02586141,-0.033395767,0.056490988,-0.01958224,0.027738553,-0.0076309647,0.011724326,-3.249648e-33,0.048714228,-0.015370414,-0.0030088485,0.038646586,-0.05445113,0.09599143,0.019955374,-0.12035154,0.02853615,0.014470407,0.15761574,-0.035089556,-0.037217673,-0.03771771,0.02170141,0.022494016,0.09250241,0.06984676,-0.09899265,-0.021601913,-0.035841778,0.04957133,-0.00544749,0.052569453,0.06946248,0.036467686,0.0861996,-0.135698,-0.050407443,0.049940497,0.026932262,0.006561314,-0.038608313,-0.055129316,-0.028199568,0.016759219,0.01776574,-0.008685125,-0.15273207,-0.025139537,-0.022829201,-0.009358367,0.044374634,0.06382927,0.016171498,-0.024897298,-0.07636556,0.039455436,-0.032054465,-0.010216279,0.023918195,0.070030265,-0.02968844,0.026868772,0.08830388,0.06909681,0.08395081,-0.066131726,0.0040270207,-0.03577517,-0.07316927,-0.027477238,0.015977854,-0.091013715,0.11950336,0.034397595,-0.026914908,0.081892155,0.08211918,-0.021340288,0.018332724,-0.018714396,0.048865937,0.043303862,-0.029268049,-0.017559467,0.008999578,-0.017630393,-0.022062214,-0.043507006,-0.04728858,-0.055866297,0.014160082,-0.08851096,-0.12325101,-0.06672146,0.013183875,0.0060092635,0.0030382718,0.075253345,0.013326181,0.012527733,-0.019374382,0.016226878,0.018771775,-3.285062e-08,0.036126874,-0.02994579,0.021930497,-0.004064261,0.056146007,-0.00291838,-0.03973771,-0.08183685,0.0109399315,0.03619583,0.0020830447,0.08058266,-0.025312621,-0.0031248096,-0.007911425,-0.034256946,0.058706194,0.033131827,-0.05363448,-0.035820495,-0.09698978,0.018673807,-0.06445921,-0.018610423,-0.011972941,-0.10546618,-0.008735764,0.014341385,0.08194135,0.010784151,0.06717358,0.049840868,0.03277066,-0.025130909,-0.08771964,-0.045290995,0.11674705,0.01489271,-0.06319451,0.0051830597,-0.04708092,-0.0037078657,0.007853124,0.024650816,-0.058280975,0.00671818,0.005153812,-0.029328715,0.026428632,0.012175107,-0.048356473,0.053052,0.0028534909,0.0073853014,-0.068165585,-0.038351923,0.02760788,-0.04274048,0.0021397262,-0.14750631,-0.013271377,-0.027178084,0.07219962,0.06286715 +1.14.13.22,"A flavoprotein (FAD). In the catalytic mechanism of this enzyme, the nucleophilic species that attacks the carbonyl group is a peroxyflavin intermediate that is generated by reaction of the enzyme-bound flavin cofactor with NAD(P)H and oxygen [2]. This enzyme is able to catalyse a wide range of oxidative reactions, including enantioselective Baeyer-Villiger reactions [3], sulfoxidations [4], amine oxidations [5] and epoxidations [6].",384,1.0,-0.07832441,-0.048431907,-0.12015062,0.05930345,0.1399611,0.062275507,-0.06424672,0.040463146,0.039905135,-0.023192458,-0.0065402025,-0.008141473,-0.113589495,0.003355123,-0.06932926,0.078584544,-0.07607261,0.012908638,-0.029933533,0.011108338,-0.020389084,0.013672931,0.06908385,-0.014508908,-0.023105182,-0.0077613406,0.028062161,-0.031793624,-0.0059319655,-0.025694119,0.10891724,0.025181722,0.050315686,-0.0140439505,-0.05221741,0.061526116,0.028871741,-0.06515029,-0.0045725293,-0.038016196,-0.02429172,-0.006839965,0.039777033,-0.050922174,0.06135046,-0.019207355,0.0066548567,0.08652272,0.00721056,0.047061525,-0.024852125,-0.050786443,-0.10497009,-0.032964263,0.025362182,0.01852614,-0.03334207,-0.13353848,-0.013989358,-0.009339966,0.04778135,-0.016733382,-0.001025087,0.031950414,0.005878854,-0.0805878,0.003544022,-0.060654107,0.0009227005,-0.03662748,0.000120029974,-0.066127576,-0.100522645,-0.011448767,0.0035603126,0.07380544,-0.037611026,-0.05698733,0.07762517,0.0244676,0.09480383,-0.023062972,0.07718029,0.10387594,0.07813256,-0.028809655,-0.019148365,0.008895838,0.022247065,0.09009165,-0.023687258,0.046272676,0.021813614,0.017540429,-0.06935573,0.07119163,0.06471466,-0.013132489,-0.062613055,-0.002884489,-0.042529076,-0.008611954,0.008417893,-0.054057747,-0.028584072,-0.03304044,-0.02075823,0.08474299,0.005314837,-0.06554126,0.009131394,-0.012328568,0.040831517,-0.09567975,-0.01017511,0.0935226,-0.01937133,-0.070830084,-0.051123172,0.024740307,-0.023303567,0.08027544,0.029244868,0.062747136,0.0066867936,-0.02776667,-0.104490936,3.3584098e-33,0.098910816,0.015002364,-0.03538816,-0.008471337,0.018552218,0.0041627507,-0.04631646,-0.008341423,-0.008039399,-0.014198252,-0.07535054,-0.031140951,0.07746046,-0.023292055,0.07381885,-0.015890593,-0.045140326,-0.055951968,0.050848138,-0.08824379,0.034223244,0.010037603,-0.0042375247,0.05197616,0.012888835,0.040936667,-0.025572203,0.036054444,0.0073346943,0.027544495,0.014752075,-0.041031957,-0.0845693,-0.010846218,-0.01660995,0.020021558,-0.13464256,-0.06444717,-0.090724856,0.083302096,-0.015458337,0.013781411,-0.08963689,-0.043557335,0.043785505,-0.07505704,-0.06546994,0.14312053,0.044543333,0.10258398,0.031799313,-0.029907618,0.059028108,0.06022774,-0.056935165,0.04981959,0.012590315,-0.0073659923,0.013735646,-0.00027651337,0.026193352,0.0015596548,0.0077833617,0.031827543,-0.037013356,0.008366397,0.012346136,-0.0645998,0.021372324,0.08059496,0.044749163,0.008024939,0.051441416,0.008995979,0.049913812,-0.026258588,-0.027752755,-0.025135001,0.031138774,0.016770758,-0.0029360126,0.018011888,0.045019865,-0.044813603,-0.009935431,0.013134683,-0.0805708,-0.025600404,0.006066462,0.006117551,0.016810847,-0.07635811,0.012740134,-0.050473236,0.016230883,-3.0398363e-33,0.014271928,-0.080155894,-0.015872326,-0.032157224,0.0026804926,0.012205845,-0.0072231363,-0.056344047,0.042052854,-0.034318577,-0.03728175,-0.035538815,0.064387456,-0.023083227,0.06535249,0.018586759,-0.004213947,0.02140882,0.033664636,-0.012765863,-0.020927494,0.011024067,0.024281155,0.06921928,0.024397464,-0.007097223,-0.01812273,-0.05310718,0.07106752,0.076029375,-0.024300113,0.02247101,-0.034388978,0.00495021,0.009631717,0.08847598,-0.0064035035,0.046455722,0.0202241,0.07362834,-0.016859572,0.021620492,0.0073378356,0.028864447,0.046750937,0.055875402,-0.10326404,-0.0041115466,0.03233596,-0.088806465,0.041487038,0.047246087,0.0042621247,0.035563305,0.059445515,0.059317455,0.06921904,0.009156795,0.04582056,-0.042244013,-0.038837805,-0.08337826,0.03735153,-0.01361519,0.06645621,0.108792916,-0.003319516,0.08678793,-0.024373472,-0.04549761,0.09287101,-0.026432287,0.016710123,0.05596089,0.011951778,-0.032973796,0.004229139,0.039806724,0.014706599,0.016675467,0.029904112,-0.009386193,0.0530023,0.0068201735,-0.09309035,-0.13612148,0.011020674,0.05113623,0.02655609,0.026618036,-0.021769013,0.03703065,-0.0032627895,-0.042157557,0.10254071,-4.435116e-08,-0.036960043,-0.08413608,0.014278072,0.0010270398,0.06428566,0.1043934,0.008047651,-0.041438244,0.020161353,-0.035837043,0.018310696,0.13427126,0.0269287,-0.022669481,0.03739508,-0.039164282,-0.016832268,0.018205835,-0.048125528,-0.015432198,-0.07339173,0.07569561,-0.051021386,-0.022172917,-0.035937645,-0.038405478,-0.035772637,-0.061694484,0.045840353,0.005420904,-0.013867679,0.05883635,0.015599499,-0.04900044,-0.17847496,0.010693338,0.06836372,-0.070889324,-0.0615981,0.042836938,-0.05586609,-0.009845038,-0.033740506,-0.021133024,-0.0129587855,-4.8370144e-05,0.02720798,-0.027327841,-0.053820264,0.009303607,0.02627874,-0.01727631,-0.029702755,0.0031546382,-0.09214504,-0.010948765,-0.01632475,-0.0546987,-0.009931514,-0.10834207,-0.008928561,0.0388483,0.18532349,0.007350608 +1.14.13.23,"A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.",384,1.0,-0.07445314,-0.10954376,-0.08216398,-0.022318015,0.06821211,0.030561201,0.03102159,0.05886653,0.040824704,-0.038104497,0.010748931,0.055965796,-0.091787696,0.0019885371,-0.084101014,0.065581724,-0.038934615,0.014324178,-0.04421749,0.02303849,-0.026293946,-0.01495699,0.10317785,-0.011551823,0.009008212,0.005503872,0.0371154,-0.0293559,0.0058253733,-0.015551029,0.10961867,0.121822454,0.04681795,-0.0064061154,-0.052642785,0.039841387,0.035701673,-0.017041443,-0.022302156,0.03181518,0.04620361,-0.056346107,0.06413962,-0.04109812,0.08791365,-0.00017463473,-0.02389154,0.06736933,0.031172682,0.037446823,-0.013571111,-0.06451677,-0.10833577,0.07704663,-0.018652368,0.036944553,-0.021354266,-0.033060435,-0.027547125,0.019569047,-0.012521591,-0.025991898,0.022340365,0.019990496,0.0076395096,-0.022811325,-0.06696754,-0.0448926,0.052240625,0.023568118,-0.01620108,-0.008717374,-0.038873676,0.008767424,-0.004739687,0.023067007,-0.06447211,-0.04349548,0.04470388,-0.05004557,0.057893228,-0.04505056,0.11300672,0.11239835,0.04128687,-0.012556609,-0.004907332,-0.008902712,-0.022009773,0.067796506,-0.027363297,0.0376461,0.01740834,0.040300835,-0.09847055,0.082212366,0.05379481,-0.002444835,-0.040984165,0.019758275,0.00031694566,-0.012698973,0.002847692,-0.019590154,-0.053672455,-0.0672479,-0.054306313,0.049915787,-0.0698565,-0.08162561,-0.06403999,-0.04531061,0.02654068,-0.08665399,0.0062592276,-0.019138739,0.0024677198,-0.05563058,0.031329963,-0.041054975,-0.019869389,0.101341955,0.061618518,0.031899773,0.023978624,0.015227396,-0.09384725,3.1818956e-34,0.08440656,0.026585711,-0.018125853,0.033400167,-0.0070685223,0.005456948,-0.04937538,-0.020309607,-0.0046114833,-0.029831128,-0.018853841,0.016310742,0.033996798,-0.05554806,0.05090951,0.009638887,-0.034830436,-0.039767567,0.09104134,-0.11544914,0.047251817,0.07304958,-0.04381051,0.02903513,-0.012519474,-0.012066924,-0.046042293,0.04273822,0.00343766,0.031195808,-0.04920595,-0.012577227,-0.07314131,-0.015145524,-0.029862966,0.07356693,-0.08330267,-0.11222078,-0.08387719,0.04007218,0.013706976,-0.042178117,-0.030092327,0.0055414895,0.05765962,-0.008816555,-0.073000304,0.12202806,0.01627121,0.09712892,0.04139218,-0.044935554,0.11610521,0.09131041,-0.08611389,0.009052425,-0.05442478,0.029152501,0.02294257,-0.015005038,0.0014015579,0.034691036,-0.01770595,0.07916892,-0.0907132,-0.031221757,-0.010972801,-0.054004632,-0.006735118,0.09431425,0.039996874,-0.016570877,0.07519239,0.04525803,0.086310215,-0.060019415,-0.043022163,-0.08813137,-0.022222,0.045338027,-0.021453867,-0.016309787,-0.017811503,0.022635339,-0.04341399,0.049851254,-0.0037998017,-0.037461277,-0.0028384735,0.00654621,0.030102352,-0.11007923,0.0085412115,0.017401218,0.0391365,4.282443e-36,0.019778177,-0.080035396,0.014505469,0.07791279,0.027540233,-0.05044571,0.06968883,-0.041265495,0.051852323,-0.036999512,0.05074494,-0.093707554,-0.019612852,0.0008469108,0.030814528,0.02043775,-0.078154124,-0.031792134,0.06770575,0.019149994,-0.02682038,-0.036846627,0.022810435,0.14389734,-0.014434947,0.0074323043,0.07814449,-0.09049094,0.022142896,0.07027534,-0.07216643,0.0063703046,-0.037791748,0.007653539,-0.05077304,0.041111726,-0.0035420253,0.010308614,-0.020485422,-0.005591242,-0.036273982,0.0040068454,0.037007276,0.055744648,0.0782554,0.09223858,-0.033294734,0.08187618,0.03636769,-0.047598943,-0.040446766,0.0055021783,-0.0042062383,0.08119488,0.066661716,0.030312456,0.054479044,0.003526051,0.002938541,0.0040494,0.007904131,-0.072488315,0.024197238,-0.014148134,0.09482455,0.08195336,0.016801078,0.121450186,-0.025185585,0.0049096667,0.09200884,-0.020180577,0.017247658,0.061529767,0.043764863,-0.05611221,-0.003876449,0.07204844,-0.02238415,0.019650748,0.035280485,-0.031346764,0.013027371,0.024414016,-0.12057502,-0.098868065,0.03439995,0.057629433,-0.035613615,0.033073828,-0.018851236,0.114076376,-0.001279702,-0.046381637,0.041954048,-2.8295606e-08,-0.0017830563,-0.05239528,0.019248605,-0.05787802,0.082585074,0.017401643,-0.052247528,0.013062516,0.004459473,-0.0239733,-0.039464854,0.10051833,0.020330196,0.0106901135,0.029014211,-0.048539087,0.004760346,0.011610859,-0.046543818,-0.047635805,-0.057043165,0.07635575,-0.058602076,-0.020096388,-0.061133225,0.006752007,-0.024080724,-0.02059724,0.06407254,-0.035604164,0.023538576,0.042357426,0.03528873,-0.04035074,-0.106781,0.07068002,0.030932873,-0.082426414,-0.042320926,0.048487157,-0.08281605,-0.058968883,-0.01476848,-0.0338795,0.010593547,-0.04701229,0.01365482,-0.03575935,-0.06356664,-0.038392957,-0.006013705,-0.017484482,-0.0037701894,-0.0030455955,-0.038346447,-0.017221117,-0.034062948,-0.08269163,-0.0024150307,-0.09819986,-0.02316481,0.039085083,0.06902124,0.033201467 +1.14.13.24,"A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions; NADPH can act instead of NADH, but more slowly.",384,1.0,-0.07973611,-0.113439284,-0.06749056,-0.021583496,0.066756286,0.058886636,0.02086995,0.06897791,0.07354272,-0.0076998803,-0.009929243,0.070022024,-0.09639971,0.031086383,-0.052955676,0.043626226,-0.036889482,0.00033191778,-0.03753504,0.0055293487,-0.0020689787,0.0041542333,0.1000185,-0.044095036,0.03400277,0.0067317532,0.0029827775,-0.030029664,0.022977576,-0.023878664,0.06891884,0.11491952,-0.006671639,0.0009822727,-0.06435273,0.058731712,0.034974195,0.0005906899,-0.034690525,0.015036069,0.044999704,-0.05317567,0.021855433,-0.023908786,0.07533943,-0.009121609,-0.024834162,0.07825327,0.02391479,0.041894477,-0.025661597,-0.06462329,-0.07558217,0.070929065,0.008269741,0.010821694,0.005214445,-0.030545646,-0.025027508,-0.02355215,-0.015862577,-0.06946611,0.022821866,0.020180935,0.025694164,-0.037041146,-0.029212685,-0.034449566,0.030629966,-0.0099293925,-0.04381097,0.001297089,-0.01942859,0.01764236,0.010513554,0.031934336,-0.089458995,-0.060085014,0.05694889,-0.028662486,0.067807615,-0.011473999,0.06687413,0.089301504,0.062126365,0.0060984367,0.0004899633,-0.005890059,-0.0392043,0.05119058,-0.039217163,0.009389925,-0.010482348,0.04865918,-0.14077924,0.063550174,0.07387427,-0.029056987,-0.036004275,0.022594096,-0.0021677297,0.053103603,0.008750258,-0.025600325,-0.06170978,-0.061285295,-0.070496626,0.06359438,-0.100917436,-0.053111155,-0.06512406,-0.06544765,0.014261644,-0.085320055,-0.014511677,0.019264221,-0.011614001,-0.046709258,-0.024494119,-0.0728026,-0.031151904,0.09023597,0.04495608,0.05412834,0.044156726,0.019191276,-0.11436537,1.1336104e-33,0.13386637,0.025552137,-0.03379432,0.025737612,0.0140118245,0.007868056,-0.042881466,0.0011737952,0.017092625,-0.036526226,0.012059792,-0.0073346607,0.039536476,-0.041086707,0.07142751,0.020182246,-0.046263855,-0.060837753,0.04608267,-0.12284366,0.06083502,0.09104819,-0.025072541,0.035129454,-0.015208858,-0.028040651,-0.074630775,0.078587875,-0.0006160386,0.027418222,-0.0018225706,-0.0310568,-0.07758553,0.003695748,-0.0090689985,0.045130398,-0.10046637,-0.12015569,-0.065409906,0.028263416,-0.032854967,-0.023496985,-0.029561853,-0.002913891,0.045911003,-0.06531674,-0.051797073,0.09802509,-0.011762573,0.09576255,0.056512028,-0.049429495,0.14171478,0.05461144,-0.07007688,0.020998847,-0.048437532,-0.007991288,-0.014754916,0.018637657,0.037984163,0.012051904,-0.016644849,0.11223055,-0.12333248,-0.0149869155,-0.055220935,-0.072662905,0.019071287,0.109598674,0.04978592,0.01120509,0.06028288,0.029379044,0.07683836,-0.0602214,-0.0018161254,-0.08912328,-0.019762969,0.041117206,-0.014410796,-0.044341963,-0.05419538,0.0020850298,-0.046954,0.0493088,0.021991182,-0.06371912,-0.01964596,-0.0061227083,0.028314238,-0.07386146,0.01354187,-0.016364336,0.06339499,-1.13379e-33,0.051793177,-0.054149244,0.044936046,0.050813,0.027930956,-0.0033318363,0.081226,-0.04696485,0.039134495,-0.06658309,0.017797653,-0.037688624,0.003097468,0.01927088,0.058709312,0.00052993314,-0.07097194,-0.04492572,0.06816706,0.03963006,-0.02764314,0.021154024,0.03018086,0.11186851,0.027370641,-0.044169962,0.034948573,-0.058733918,0.016372884,0.06407996,-0.05555127,0.018015072,-0.061351538,0.004785326,-0.030155355,0.038386516,-0.0011890557,0.0014362629,-0.033459384,0.010612575,-0.032695252,-0.023721755,0.005085128,0.04115528,0.082090564,0.0791637,-0.06137585,0.06117948,0.06624627,-0.058769453,-0.0074406,0.02813031,0.00053691067,0.07776591,0.10164159,0.03328886,0.018586684,0.014475152,0.01092455,0.0102940025,0.027444925,-0.07496996,0.009503899,-0.01589465,0.1116581,0.047935527,0.011549828,0.07523322,0.012896947,-0.007473756,0.10383892,-0.0019356165,0.0101098595,0.06232582,0.03828571,-0.100650616,-0.032217298,0.07273278,-0.04347847,-0.0019316833,0.022715935,0.0021105742,-0.00024634256,0.012964296,-0.1090165,-0.049201034,0.035261955,0.048761833,-0.037681434,0.0294906,-0.012724093,0.123366475,0.015136714,-0.023448652,0.018575694,-3.308995e-08,0.017560553,-0.041119546,0.033946764,-0.049842633,0.07601125,0.0013253187,-0.020541703,-0.029318344,0.0043316893,-0.013303911,-0.04497015,0.14024934,0.061428916,-0.0035800012,0.048553865,-0.052502703,-0.014525808,0.009485427,-0.056598306,-0.035589557,-0.06006117,0.060194924,-0.078164816,0.015906394,-0.05655463,-0.0070677632,-0.006901738,-0.03662577,0.04978912,-0.047222205,0.023162039,0.013609891,0.06700074,-0.045382027,-0.104593284,0.08300301,0.01606413,-0.053506963,-0.040765394,0.06603892,-0.059285704,-0.06546758,-0.012803281,-0.007934761,-0.016504666,-0.029705724,0.015347839,-0.070154116,-0.062242616,-0.018045684,0.025087278,0.005768547,-0.0040129153,-0.007515122,-0.045528173,0.008324962,-0.032511994,-0.082980454,-0.007477358,-0.09033764,0.015393921,0.038496394,0.05898414,0.0166448 +1.14.13.25,"The enzyme is soluble, in contrast to the particulate enzyme, EC 1.14.18.3. Broad specificity; many alkanes can be hydroxylated, and alkenes are converted into the corresponding epoxides; CO is oxidized to CO2, ammonia is oxidized to hydroxylamine, and some aromatic compounds and cyclic alkanes can also be hydroxylated, but more slowly.",384,0.99999994,0.018791575,-0.03628781,0.019026585,-0.026050977,0.11401479,0.032494355,-0.067029364,0.012213243,-0.041523293,-0.06585212,-0.0047713653,-0.033751078,-0.08837288,0.027029486,-0.042548396,-0.010235063,-0.01905376,-0.03834919,-0.045853708,0.00034771525,0.06737606,0.019970307,-0.0774018,-0.004409857,0.03539831,-0.025419192,0.06517057,-0.066421166,0.03371052,-0.043451224,-0.008739507,-0.0069544557,-0.0508063,0.014286343,-0.048431918,0.05666815,-0.0021920537,-0.0046073603,0.0058472613,0.0117914425,0.03334313,-0.019267805,-0.07815459,-0.081115596,0.023501776,-0.07188075,0.07474199,-0.04372931,-0.05574028,-0.022405831,-0.016415901,-0.075428724,-0.09246821,0.044672318,-0.028226877,-0.013669459,-0.07397777,0.017360404,-0.047650877,0.012768426,0.03864186,0.023784466,0.0054125106,0.028810814,0.017994225,-0.10299517,0.13492028,-0.05513665,-0.021614328,-0.07115464,-0.07427871,-0.055257082,-0.011585903,0.0037367933,-0.026816765,-0.04033299,-0.06029128,-0.073580794,0.057302874,0.057878822,0.056491725,-0.0041300026,-0.014530583,0.072952814,0.069493465,0.037000973,-0.032888252,-0.013582135,-0.016682044,-0.032925263,-0.035192873,0.0028168876,0.024404274,0.022008302,-0.024873735,0.038288485,0.12217108,0.087729394,0.072980516,0.010162988,-0.057236675,0.052966878,-0.0928879,-0.121312305,-0.07389936,0.0015910704,0.0700689,0.078945756,0.01077234,0.05993195,-0.04306657,0.041844074,0.018867042,-0.051761344,-0.018792393,0.057657134,-0.0075909086,-0.07240305,-0.012957426,0.050848097,-0.050781757,0.015356282,0.101254724,0.10946601,-0.026838427,0.03894104,-0.013727568,2.9540818e-33,-0.0018626315,-0.00536187,0.00064316276,-0.023291895,-0.028539848,-0.003956797,-0.039159063,-0.014725458,0.024169939,-0.0586911,-0.054631144,0.06203724,0.009481055,0.03194371,0.017795013,-0.042873554,-0.011975636,0.049178414,0.022781214,0.039813448,-0.00532951,-0.002460655,-0.12013888,0.057501048,0.010586112,-0.034550082,-0.044212285,0.03654804,0.0033273196,0.0028828066,-0.027079232,-0.081803836,-0.108599246,0.019418616,-0.00062548014,-0.037032414,-0.027875999,-0.005704524,-0.025273291,-0.032599952,0.04413697,-0.0053201816,0.035179492,-0.08112798,0.05406189,0.033323452,-0.073714525,0.09770541,0.042650115,0.01654681,-0.0071527995,0.021102859,0.03171376,-0.03613923,-0.050443042,0.043785527,0.048908796,-0.031234289,0.05458418,0.06751575,-0.05064613,0.04515542,-0.005587048,0.020324836,-0.0066758357,0.020980977,-0.06210687,0.058321994,0.012185851,0.010089182,-0.07275866,0.052142404,0.0885711,0.012455201,0.03323698,-0.07910825,-0.021285085,0.0420233,0.04591799,0.047584087,-0.019162126,0.001756989,0.0024013899,-0.050299115,-0.043708425,-0.007311912,0.0018588693,-0.017311275,0.022458566,0.107085556,0.061285388,-0.045275617,-0.0057685724,-0.06075191,0.04700631,-5.742526e-33,0.09377318,-0.036176484,-0.05767159,-0.086897396,-0.016230764,0.0814778,0.052642837,0.03997043,0.05377198,-0.04256993,0.023659827,-0.0021764713,-0.0091432035,-0.020777037,-0.029070012,-0.0023508365,-0.079556,0.078759104,0.08104076,-0.00036635133,0.0055868328,0.0036974454,0.02930584,0.02781509,0.100857615,-0.011713175,0.0057241796,0.025602149,0.049039815,0.06559531,-0.031961054,-0.08218241,-0.012632035,0.031459235,-0.08957295,0.0134962285,-0.084217824,-0.0037994373,0.013713343,0.014991008,-0.022432514,-0.028667908,-0.03790153,0.0768966,0.008505228,0.13460907,-0.041667193,-0.054823343,0.06115001,-0.069423325,0.07994513,0.055000223,-0.0238018,0.017972587,0.012846098,0.048358135,-0.0051144334,-0.018685412,0.007425707,-0.017958943,-0.04337035,-0.040470008,0.028013758,0.0031819297,-0.02038158,-0.03044851,-0.06994611,0.020613803,-0.020480022,-0.022246823,0.06346296,-0.09493504,0.057479043,0.048077196,0.024253838,-0.081589274,0.058718618,0.007516274,-0.08455449,-0.09977468,0.07550682,0.0455087,-0.023736816,-0.02641511,-0.026959196,-0.039295364,0.03011824,0.003658338,-0.008581026,0.017244596,-0.0030438516,0.051268965,-0.03675335,0.021629596,0.06604021,-4.610792e-08,-0.0072199027,-0.05422557,0.07511538,-0.054293595,-0.016551036,0.098065205,0.034968175,0.0062821996,0.05325541,-0.009900391,-0.032952532,0.044796214,-0.039476033,0.031277705,0.031530384,-0.04976379,-0.08894008,0.09044258,-0.009216779,0.021065028,-0.064848386,-0.011429534,-0.07785857,0.03579191,0.004786699,0.018683586,0.022574091,0.023379754,-0.029739881,-0.014179836,-0.08893009,0.065864995,0.013142106,0.03139073,-0.11716368,0.0063167796,-0.0026053314,0.012745142,-0.120193854,0.028681949,-0.0011969252,-0.050297055,-0.059883103,-0.03231893,0.09915231,0.005675311,0.03462486,0.034784943,0.062063076,0.03172675,0.07881638,-0.035625998,0.00078035385,-0.08106446,-0.06438393,2.0109014e-06,-0.1095578,-0.07144079,-0.01878957,-0.10233261,0.047154848,0.09038027,0.20156674,-0.01072671 +1.14.13.27,A flavoprotein (FAD). Acts on anthranilate and 4-aminosalicylate but not on salicylate (cf. EC 1.14.13.1 salicylate 1-monooxygenase).,384,1.0,-0.075361446,-0.080790885,-0.095233336,-0.0042534936,0.14115077,0.029123105,0.008042176,0.034109235,0.059423964,-0.047584016,0.0037142346,0.04354783,-0.06152455,0.044967674,-0.09003415,0.07372989,-0.0788698,0.01738019,-0.036753207,0.015889104,-0.007776055,0.009956821,0.048675258,-0.035876937,0.035056904,-0.042710654,0.007757107,-0.07092684,-0.072720595,0.00048658688,0.09366933,0.055225972,0.07070072,0.0046290774,-0.025849046,0.08716303,0.045380533,-0.027745025,0.01404647,0.053284362,0.047745958,-0.041327804,0.037748285,-0.045260385,0.046422806,0.009110029,0.00744348,0.049477696,0.0067203366,0.04258604,-0.038367238,-0.03968712,-0.12611943,0.016064394,-0.022649333,0.013601879,-0.057740577,-0.070084706,-0.03490579,-0.0015744977,-0.034011245,-0.037300374,0.070090696,0.035876323,0.042764805,-0.08767476,-0.00081586826,-0.048395075,0.060196873,-0.049018618,-0.0071001346,-0.018895797,-0.06466518,0.024603037,0.002275474,0.028437506,-0.052559365,-0.035580005,0.075529054,-0.03911649,0.052985936,-0.0206284,0.11777013,0.061033174,0.049204804,-0.029757977,-0.0021637145,0.005524235,-0.0062763793,0.052993234,0.002525476,0.026213003,0.038294647,0.051066853,-0.06336806,0.013920381,0.067650236,-0.04120098,-0.074527584,-0.0026955486,-0.07151667,-0.0051344167,-0.016254552,-0.004668575,-0.022557668,-0.07117693,-0.07824045,0.062676415,-0.082382396,-0.09558861,-0.0031828114,-0.042960405,0.069101885,-0.058880553,0.033509787,0.04788592,-0.015870031,-0.08083282,-0.041328352,-0.014814792,-0.06893533,0.07075162,0.054082666,0.10939486,0.033623006,0.032841273,-0.07816541,2.5799456e-33,0.08713495,-0.014346358,0.005988272,-0.011581179,-0.02054991,-0.007966109,-0.025506757,0.0057814093,0.020965446,-0.02596632,0.012205078,-0.00732106,0.06954768,-0.016904628,0.039591283,0.0033638112,0.0013249376,-0.05087624,0.043227136,-0.101492584,-0.005828262,0.078341976,-0.030387841,0.04214657,0.00043321686,-0.021203946,-0.07880636,0.036799055,0.048105102,0.024772532,-0.019957857,-0.04984209,-0.07687167,0.0069717374,-0.026409796,0.04943971,-0.10138886,-0.089628816,-0.1183044,0.07400999,-0.022414034,0.02894547,-0.042076476,-0.037384126,0.05294131,-0.029771088,-0.09798561,0.15834741,0.016547166,0.08097655,0.027909819,-0.01628803,0.14929076,0.05101117,-0.07296736,0.022559593,-0.04815063,-0.011722521,0.017495641,0.011149482,0.013426572,-0.004782742,-0.042679816,0.06674683,-0.05797244,0.018723484,0.0017438243,-0.06149063,0.0220909,0.13804795,0.050421186,0.0075285137,0.055398718,0.04788016,0.047957305,-0.048709195,-0.029783955,-0.01947433,0.0031983675,0.057077087,-0.013843084,-0.013978318,0.00034181232,-0.013160636,-0.049343396,0.013467294,-0.0059322943,-0.043704275,-0.0052033206,0.049650885,0.028672697,-0.06265012,-0.024349399,-0.0068481606,0.03944642,-2.3795993e-33,0.03622718,-0.08810645,-0.05384987,0.039181486,-0.032463275,0.06145319,0.04981491,0.0034884722,-0.0016232806,-0.025125617,0.031853907,-0.072778754,0.00060843874,-0.0022440283,0.03303413,-0.0043894593,-0.036799118,0.018332588,0.03498034,0.09036592,-0.0777726,-0.0054829777,0.030234339,0.07995621,0.049368497,-0.0060957693,-0.019999435,-0.035004847,-0.0035805388,0.014206016,-0.047037337,0.06050082,-0.08126799,-0.009760006,-0.066366166,0.043998092,-0.014997548,0.000726765,0.00544058,0.020334663,0.01386481,0.015175513,0.0078612715,0.10820713,0.07771683,0.058413617,-0.05322549,0.062045347,0.059816755,-0.078906745,-0.07347096,0.025476763,0.05917297,0.044220522,0.06608365,0.051316068,0.035020135,0.0027451722,-0.02754064,-0.03797606,0.003221165,-0.12233224,-0.0036705865,-0.004003414,0.08446438,0.060561065,0.028971504,0.07994498,0.024556458,-0.022450153,0.12598589,-0.02824316,0.067850664,0.05183724,0.022326728,-0.044622213,-0.03298566,0.07284129,-0.0022760474,0.013639452,0.042072505,0.0023492817,0.021492446,0.017579816,-0.065172575,-0.092168406,0.036650512,0.06542347,0.015834361,0.045616213,-0.0044812458,0.038899343,-0.0036048589,-0.042312462,0.065230235,-3.3716024e-08,0.03111512,-0.04022111,0.044320084,-0.05179971,0.050187718,0.057123855,-0.012826752,-0.03786498,-0.032022756,-0.025007712,-0.04155024,0.12684457,0.010101393,-0.018455446,0.050261855,-0.04328885,0.008134146,0.006115527,-0.037536796,-0.025009356,-0.10897935,0.041786,-0.0817096,0.030795587,-0.07498197,-0.03848738,0.023604317,-0.023364488,0.041531377,-0.036137193,0.0039287247,0.008456597,0.032590773,-0.05331794,-0.12527825,0.028201947,0.05148809,-0.07828176,0.01097512,0.03202412,-0.06826697,-0.020063473,-0.019407377,-0.042613458,0.04606751,0.013916383,0.020591373,-0.06339409,-0.06799154,-0.041946825,0.041412417,-0.013345862,-0.0057730637,-0.011453104,-0.065833874,-0.0030652364,-0.010719462,-0.083875686,0.0039779153,-0.0864069,-0.017260982,0.050674416,0.1059729,0.0059972554 +1.14.13.28,Possibly a heme-thiolate protein (P-450). The product of the reaction is the biosynthetic precursor of the phytoalexin glyceollin in soybean.,384,1.0,-0.097066864,-0.0018652607,-0.0738563,0.0011855352,0.10302055,0.074547224,0.020731036,0.09944319,0.056160737,-0.04632513,0.079230726,0.022099646,-0.063726105,-0.051401183,-0.051396646,0.035694417,-0.018459167,0.036913898,-0.04424515,-0.11095428,-0.0006398183,0.1082778,-0.0012205017,0.002649422,0.019957703,-0.0021361036,0.064067334,-0.036503762,0.011337755,-0.042888116,-0.0015518257,-0.061069217,0.026006108,-0.008347223,-0.02951952,0.13470027,-0.06219709,-0.11187028,0.07266554,-0.06936786,0.097412504,-0.047407087,-0.022910802,-0.05903836,0.00211941,0.04317295,0.009561257,0.017448984,0.08546481,-0.023483317,0.0047015278,-0.065616116,-0.014515059,-0.028243555,0.01806026,-0.024690244,-0.011864171,0.0050617303,0.018694928,0.024301933,-0.06508642,0.051234186,0.039942723,-0.0075417515,0.004212662,-0.072982155,0.010237537,-0.037439004,-0.02207996,-0.037214015,0.036246713,-0.027169008,-0.018365812,0.02756782,-0.02047082,0.06994236,-0.056440346,0.046506952,0.061175834,0.03639012,0.055395126,-0.026533794,0.045808475,0.12228081,-0.027963875,0.029414961,-0.04124274,0.026926687,-0.034146678,-0.047940474,-0.020459548,0.017829482,-0.022222407,0.07431425,-0.044120282,0.06966969,0.004992764,-0.05373794,0.023624929,0.0038337908,-0.05594308,0.024831645,-0.02603754,-0.11090301,-0.077596754,0.032900568,-0.04295193,0.004459227,0.05532795,-0.012445684,-0.03338436,-0.018130448,0.004745091,-0.002367784,-0.050049916,0.059663426,0.012970443,0.010726402,-0.044385705,-0.04613149,0.062231354,0.013947323,0.021481214,0.020273564,-0.11442582,-0.023972673,-0.045081206,1.35072695e-33,0.064741835,0.0065633333,0.008968414,-0.013190376,0.030024549,-0.037532475,-0.08964255,-0.051320285,0.009604141,-0.05098217,-0.056672193,-0.12280238,-0.026917676,0.047654945,-0.034543253,-0.0433573,-0.06000825,-0.021496285,0.093480304,-0.013270279,-0.06381449,0.019625468,-0.025694266,0.024846356,-0.0159482,0.054857466,-0.005551877,-0.030482367,0.028574936,-0.005132515,-0.017595494,-0.022828985,-0.047239143,-0.047457222,0.0007620505,-0.03087046,0.0076488396,-0.06300596,-0.0714171,0.07017866,-0.013723745,-0.026261877,0.010963595,-0.030360328,0.030637402,0.021825667,-0.03707599,0.07724227,0.048827067,0.05107909,-0.013573212,-0.02436811,0.14145622,-0.042561002,-0.02213204,-0.030005442,0.040084705,0.06083193,-0.007099552,0.08204522,0.034663636,0.097087465,0.0065256204,0.041920308,-0.0012422558,0.04865149,-0.044575304,-0.0021818627,0.03862056,0.04851951,-0.009460651,-0.0010786656,0.0875156,-0.011887012,0.038849387,-0.097077794,0.0026017358,0.06440323,-0.029090375,-0.0113932155,0.043344773,-0.011522246,0.02475999,-0.004805037,-0.05686963,0.080380745,-0.07065863,-0.023928815,-0.02496853,0.05781626,0.0678876,-0.0058158333,-0.06261402,0.035209745,-0.08263021,-1.2301491e-33,0.070597604,-0.07620117,0.03940521,0.032643657,-0.0060374397,-0.010198706,0.0031785779,0.01810039,-0.00945694,0.015452418,0.092009865,-0.12346764,0.011523939,0.004521199,-0.018751694,0.098700985,-0.016581772,0.02396121,-0.02662178,0.0046909577,-0.028070545,0.006840584,0.049400378,0.016446222,0.09400485,0.0658554,0.013659945,0.033513587,-0.015384367,0.008954946,-0.035576187,-0.034025006,-0.066111214,-0.016710712,-0.040508736,0.004695167,0.029533157,-0.051643882,0.022577446,-0.033250723,0.015239653,0.038719393,0.06168036,0.039020985,-0.004019144,0.06211391,-0.058447868,-0.03477987,-0.007024798,-0.048793513,0.003938279,0.105885796,0.01730577,0.057776943,-0.03364554,0.026095867,0.0021115413,0.039640624,0.026042324,-0.004432347,0.031865254,-0.073695436,0.012871602,0.054090608,0.095930554,0.07060373,-0.035940368,0.043684535,0.0734804,0.029746039,0.08305701,-0.019653719,0.054556575,0.033728056,0.0013421259,0.013726196,-0.019964425,-0.0132444585,0.021884205,0.04116273,0.024768654,0.0076253396,-0.060068883,-0.055025138,0.043358963,-0.044816297,-0.06838917,0.19260764,0.0592607,0.015304242,-0.017349636,0.021766238,-0.10634267,0.06623006,0.08359185,-2.717529e-08,-0.0032161516,-0.11160831,-0.02254277,-0.07245772,0.052260265,0.039779563,-0.010643294,-0.009431191,-0.004497451,-0.05972233,-0.097474344,0.06360948,-0.0676861,-0.014429453,-0.039407305,-0.015677562,-0.051731747,0.077788234,0.027166931,-0.03651044,-0.061852332,0.02266595,-0.071250506,-0.005209595,-0.017524512,-0.07190638,-0.035388764,0.08650348,0.044891097,-0.058145724,-0.018754007,0.059494887,-0.057875387,-0.109753996,-0.013981969,0.058136083,-0.079913355,-0.026402052,-0.016846078,-0.02166068,-0.05507411,0.019598596,-0.0021229459,0.0005775822,-0.020605898,-0.007942148,0.048961356,0.062621556,-0.027748885,-0.0072007934,0.02709508,-0.02644218,0.015275345,-0.04749886,-0.13254808,-0.045794368,0.05405585,-0.043078125,-0.054357074,-0.07832748,-0.037864435,-0.03375562,0.18098252,0.05726715 +1.14.13.29,A flavoprotein (FAD).,384,1.0,-0.060215138,-0.08059517,-0.09776585,0.05920577,0.04895456,-0.007779169,0.08250401,0.08624089,0.04576716,-0.04610633,0.014117844,0.032441754,-0.06571716,-0.01322701,-0.09982518,0.007113922,-0.039412525,-0.042328954,-0.06530897,-0.013698858,-0.07787378,0.019375715,0.050914396,-0.007731047,-0.021849548,0.0018844825,0.021399798,-0.049960885,-0.037254345,0.001489757,0.096044205,0.070055865,0.041591503,0.007257611,-0.030690407,-0.0012432643,0.038097586,-0.012184579,0.005644652,0.008963193,0.053935524,-0.04615204,0.04862307,0.0033053851,0.05689465,-0.0043301056,-0.034646012,0.111042306,0.014167936,0.06529614,-0.01308926,-0.07599109,-0.11671194,0.018468348,0.019921627,0.018663704,-0.027367322,-0.05093831,-0.020190945,0.04349999,-0.044097204,-0.02247833,0.057994217,0.006598579,0.052564356,-0.086190514,-0.0234275,-0.02652962,0.09487984,0.014966777,0.046283673,0.01896531,-0.070308,0.07778589,0.017060578,0.030859213,-0.04845906,-0.04726871,0.09008063,0.009851278,0.08461364,-0.0050276285,0.0788161,0.06904051,0.053640082,-0.041468784,0.0014142009,0.0016655737,-0.087788306,0.05539823,-0.03915923,0.020883294,0.0010806228,0.013243423,-0.06285993,0.05387198,0.042711794,-0.07203253,-0.13497056,0.025480505,-0.0558107,-0.03848178,0.07282992,0.024361378,-0.08010056,-0.06915012,-0.030065749,0.025514152,-0.021697564,-0.07285193,0.003768324,-0.035151985,0.026424762,-0.08171922,0.027826525,0.00066680147,0.011764195,-0.031770892,-0.008920709,-0.000485261,-0.056652103,0.104300044,0.04231766,0.06484951,0.010475294,-0.019723134,-0.075603046,-1.6931352e-33,0.0706775,-0.00274842,-0.0016870318,0.04512353,-0.0010430086,0.044651322,-0.034967653,-0.007999142,0.03149864,-0.029454077,-0.021666288,-0.011627095,-0.019824637,-0.030011905,0.06082323,0.03691845,-0.037378978,-0.033638507,0.041482776,-0.11088397,-0.0268196,0.07698712,0.01464412,0.033632234,-0.0010980364,-0.0374243,-0.07635965,-0.01715701,0.02588975,0.04903531,-0.03558572,-0.0033243513,-0.009887427,-0.023018347,-0.055812042,0.019016901,-0.05863613,-0.10375395,-0.10186671,0.071181454,0.017174745,-0.039456017,-0.029588351,0.01159062,0.0060380176,-0.023514893,-0.067867436,0.08251371,-0.035464548,0.065559216,0.030587906,-0.03955036,0.13789548,0.079426594,-0.101576,0.0062416573,-0.01567028,2.0335125e-05,0.014415136,-0.007561558,0.044023074,0.07218223,-0.046447977,0.07889049,-0.1072334,-0.04707545,-0.045121357,-0.042296372,0.0040691253,0.096143864,0.058384128,-0.012066658,0.094422236,0.0006445984,0.042967316,-0.024009833,-0.032452524,-0.0157232,-0.049025916,0.021962335,-0.037277464,-0.02037369,-0.004299304,0.009134822,-0.04160973,0.047667924,-0.027277328,-0.02591006,0.024100933,-0.018015362,0.0066994647,-0.04382823,-0.006628641,-0.017475598,0.02123402,1.0153532e-33,0.008360983,-0.11396023,-0.0018192654,0.09841543,0.054551505,-0.013978537,0.031113878,0.0015807153,0.027808089,-0.02376798,0.017483331,-0.12273573,-9.1393245e-05,-0.014554717,0.06555467,0.07592327,-0.028304685,0.050297223,0.056193657,0.03656508,-0.082642645,-0.060615297,0.06540341,0.123492226,0.029894967,0.0033364994,0.06252617,-0.10327796,-0.037445042,0.037952323,-0.03980215,0.026372517,-0.060936637,-0.03960751,-0.081494175,0.022115314,0.016462842,-0.061477896,-0.03225264,0.012262953,-0.010193331,0.03903185,0.04716151,0.07952242,0.07860841,0.057538886,0.010400908,0.06688467,0.066902615,-0.027851243,-0.034170937,0.027568053,0.0007672426,0.10082057,0.032723185,0.009390105,0.061720714,0.061782185,-0.008308272,0.017573128,-0.004942049,-0.1186768,-0.04625238,0.015540812,0.09503532,0.051661417,0.023901846,0.091914,-0.013711302,0.011299677,0.12142794,-0.0154574085,0.008418382,0.07149506,0.04409036,-0.020740362,-0.02636856,0.09109474,0.012116535,0.028788514,-0.04722731,-0.04236982,0.002920832,0.020281713,-0.05142227,-0.13776563,0.021058654,0.034298994,-0.0013028621,0.029894771,-0.03688143,0.05827898,-0.058177203,-0.05683608,0.0403702,-1.7324538e-08,0.031077601,-0.054990705,-0.041843772,-0.03301297,0.09767739,0.028651467,-0.037483767,-0.013034313,-0.005746581,-0.012211182,-0.03989884,0.111961365,-0.019815927,0.0035198694,0.035600137,-0.052370038,0.030791469,0.029284338,-0.018894948,-0.039178383,-0.051253557,0.050279677,-0.008178415,-0.001772216,-0.10129571,-0.017734282,0.0007510125,-0.0039930064,0.04207133,-0.011360177,0.028705735,0.027104337,-0.012558231,-0.05830674,-0.12323721,0.0454348,0.06953549,-0.05865077,-0.023883168,0.058581177,-0.1030977,-0.019372163,-0.0016231318,-0.05252629,-0.00391698,-0.040820338,0.04613004,-0.022228617,-0.03709832,-0.03600059,-0.0026573723,-0.008889679,0.01972325,0.032237757,-0.027522145,-0.04114436,0.007567475,-0.03718464,-0.040234666,-0.07876971,0.011906499,0.05617084,0.10108727,0.047212146 +1.14.13.30,"A heme-thiolate protein (P-450). Not identical with EC 1.14.13.34, leukotriene-E4 20-monooxygenase.",384,1.0,-0.06939196,0.04787089,-0.027172547,-0.024081482,0.094541125,0.053925846,-0.0546042,0.12434307,0.021273235,-0.06617861,-0.014609324,-0.048497263,-0.023306029,0.032962494,-0.021988027,-0.012728771,-0.026129501,-0.0068040313,-0.034275256,-0.12707879,-0.037710916,0.049071167,0.008610142,0.01336885,0.015228047,0.0070674405,0.07786859,0.05505761,-0.05878522,-0.007649185,-0.00786248,-0.07179571,0.047428716,0.009943703,-0.038943157,0.11386073,-0.08910927,-0.056492466,0.010114078,-0.026338745,0.08065813,-0.058405098,-0.08204162,-0.030643864,-0.042865627,-0.025364768,-0.043167554,0.014414219,-0.009564636,0.04609696,0.027749091,-0.028416418,-0.06553677,0.01077228,0.015785031,-0.042626247,-0.020955648,0.03599334,-0.016462585,-0.016475031,-0.053558897,-0.0074093323,0.02356617,0.057367016,0.014609149,-0.017116299,0.04312093,-0.04536305,-0.04678954,-0.07678785,-0.02383716,-0.031171788,-0.019259002,0.033114966,-0.07423858,0.09376154,-0.0667021,-0.024978383,0.0039516794,-0.0074309735,0.045190677,0.057735663,-0.010246494,0.07216871,-0.008203385,-0.01496496,-0.007010239,0.021617027,-0.06327625,-0.036692653,0.030450292,0.015809467,-0.029029906,0.031197546,-0.024346638,0.047763813,0.053265076,0.033954915,-0.018341698,-0.032878004,-0.029517146,0.06944104,-0.05035998,-0.048406195,-0.052906092,-0.011247521,0.0016736337,0.046586465,0.011108067,-0.060958315,0.03041878,-0.06805253,0.061893087,-0.010520836,0.06733718,0.08691439,-0.017475538,-0.033460326,-0.03512094,0.017456489,-0.0032790557,-0.054462012,0.0577474,0.031770032,-0.037900086,0.0022072205,-0.014436787,-1.501382e-34,0.06807568,-0.0074797166,0.029966922,0.017283145,-0.009016095,0.007016217,-0.06682783,0.09878572,-0.04597874,0.0059238225,-0.023144467,-0.030832399,0.053524893,-0.036399614,-0.06288966,-0.036949854,-0.023252266,0.04207212,0.029960116,-0.001354883,-0.059537053,0.01111185,0.007526869,0.042533956,0.0007157996,0.06073678,0.0037001406,-0.019758014,0.04675416,0.0019183231,-0.06459269,-0.046430416,-0.050014306,-0.055144228,-0.053512063,-0.022107465,-0.017368514,-0.00566065,-0.06860975,0.015814424,0.014480267,0.0031277193,-0.014541318,-0.14205053,0.080565065,-0.05019727,-0.08475005,0.05615271,-0.0008702902,0.07019069,0.02846043,-0.00914835,0.120246366,-0.016403975,-0.040557057,-0.009350017,-0.038358968,0.05346659,0.033776682,0.08070631,0.1414272,0.085706495,-0.046334237,0.018520666,0.05649797,0.0722748,-0.076481104,-0.050076425,-0.020864272,0.10990874,0.057895243,-0.005253738,0.08059189,-0.016020212,0.04110451,-0.0220822,-0.033720177,0.09883607,0.02133829,0.038073115,0.009338451,0.04258912,-0.024805622,-0.04547382,-0.020650784,-0.024807973,0.026763415,0.00069791265,0.034937713,0.020363932,0.08087159,-0.097731896,-0.066131175,0.020717373,-0.014728918,-7.2544445e-34,0.071167335,-0.06104041,-0.019792937,-0.049452778,-0.003064481,0.12282784,0.06703397,0.0131717585,-0.024036676,0.08228666,0.20839317,-0.013991153,-0.00029437742,-0.05315038,0.0540135,0.019184329,-0.08344128,-0.0057609337,0.011895957,0.07731051,0.017901743,-0.0128298635,-0.0013332918,0.06011934,0.07677755,0.060721032,-0.04184078,-0.007401682,0.044435922,0.025777565,-0.05415179,0.06380682,-0.08141345,0.020417195,-0.029311594,0.013634124,-0.010426426,0.0021371003,0.026332881,0.0051645576,-0.0820603,0.04948594,0.07180562,0.064287536,0.07394758,0.09323277,-0.071560144,-0.03540346,0.0370697,-0.0759004,-0.029446926,0.064500496,-0.044135705,0.019639554,-0.04136385,0.019169915,-0.033694845,0.055529468,0.009858172,-0.12507962,-0.035260916,-0.053999413,0.01651013,0.09478635,-0.024755856,0.03643313,-0.08529513,-0.012427639,0.02060648,-0.010136188,0.037228853,-0.07129912,0.06815667,-0.04006132,0.04257963,-0.001922433,0.045469683,-0.010151059,-0.0019575593,0.02702398,-0.0077136937,0.033031482,-0.060808044,-0.051333856,-0.045572802,-0.07564713,-0.026535982,0.08149741,0.010991652,0.012001281,-0.053679857,0.053788923,-0.119000934,0.03175826,0.09362222,-3.3155477e-08,-0.01078135,-0.093615584,0.043626085,0.00184015,0.010455213,-0.002102949,0.038223002,0.02967253,0.041934922,0.026641687,0.025306419,0.009683418,-0.033112355,0.00069766684,0.030293947,-0.021446917,-0.052427296,0.01859598,0.045040768,-0.00075298146,-0.027887477,0.005916786,0.005964037,-0.029326506,0.0035424095,-0.08182199,-0.04721949,-0.057289798,0.010040372,-0.03215892,0.005392201,0.058090247,-0.024434032,-0.039365813,0.03293831,0.027545558,-0.026955605,0.04405585,-0.060203534,0.0055071674,-0.04140624,-0.10767639,-0.062067106,-0.04452882,0.09095606,0.047171578,0.068599544,0.025549695,-0.05638835,-0.06781938,-0.038609255,-0.028880656,-0.010827565,-0.07143647,-0.06548213,0.016631443,0.012830937,-0.106124975,-0.009377528,-0.084343016,-0.003940045,0.008535054,0.19339387,0.013587892 +1.14.13.31,Involved in the metabolism of nitro-aromatic compounds by a strain of Pseudomonas putida.,384,1.0,-0.040664136,-0.022207635,-0.07730903,-0.01980273,0.02034249,0.0615065,-0.03014511,0.053951763,0.05367358,-0.06960533,0.0030625768,-0.030400036,-0.0915585,0.057882983,-0.05066623,0.0045026243,-0.015294479,0.015451118,0.0076815234,0.030496402,0.015535222,0.06842311,-0.07749516,0.0009618068,-0.025409054,0.033909213,0.01405678,-0.006980138,-0.0032294772,0.020800319,0.01664988,-0.029674096,-0.028581824,-0.10878485,0.0611657,-0.008185193,-0.0043668128,0.038486224,0.055893295,-0.046673913,0.027784022,-0.027371857,-0.04617109,-0.03329477,-0.0071778023,-0.021471564,0.04192511,0.051095437,0.043716338,-0.09674697,-0.060316097,-0.019364016,0.06408623,0.04134412,0.019892301,0.04760823,-0.017325629,-0.021008117,-0.06183293,0.021094844,0.01954459,-0.040224,0.02759671,-0.027850678,-0.0077929352,0.02578637,0.061379623,0.004696676,0.04704396,-0.04682307,-0.046709027,-0.016953764,0.07264542,-0.010354409,-0.055690877,-0.016021328,4.4467495e-05,-0.019610105,0.026033534,-0.09741344,0.002849054,0.005034452,-0.0066767246,0.07061389,0.014630193,-0.052864894,0.0061134393,0.08003909,0.043710515,0.07410348,-0.027262228,-0.0053945826,0.024639543,-0.05815167,-0.04327089,0.040089887,-0.008931954,0.08081361,0.043338038,-0.01967176,0.031433374,0.0275772,0.0068651,-0.06844928,-0.10060879,0.02272052,0.095417894,0.044134628,0.0614591,0.03342235,0.03784867,0.05557157,-0.014142925,-0.063271016,-0.016281685,-0.022006782,0.0660589,-0.0682915,-0.13589068,-0.007850282,-0.066575594,-0.05909731,-0.0004611828,0.057848997,-0.039229855,0.019782756,-0.01581163,-3.3242977e-33,0.047686104,-0.016720992,-0.020121818,-0.035983067,0.08129636,0.008128883,-0.113588266,-0.037224084,0.046365105,-0.03778125,-0.016538136,-0.110697925,-0.045457117,-0.07488503,0.030879015,0.03787272,-0.031305753,0.0576766,0.11211206,-0.0062870528,0.02053815,-0.0044747475,-0.07752905,-0.021485962,0.03448875,0.035480183,0.021924926,-0.07487221,-0.049563184,-0.038154256,0.058015384,-0.059771974,-0.07558319,-0.06207803,0.07365519,-0.038818054,-0.020781938,0.06665968,-0.05828672,0.07410904,0.06263764,0.060280137,0.0021382524,0.0065302365,0.031494237,-0.0008643135,-0.05762084,0.18428196,0.05506979,0.06587292,-0.010802596,-0.11617672,0.030365923,0.060920633,-0.044663396,-0.0018944186,-0.026415857,0.004435125,0.08785182,-0.048192944,0.06458441,-0.0051170522,-0.050253913,0.0038667286,0.007901863,-0.0330263,-0.057561822,0.067262545,0.074656166,0.035605486,-0.10544932,0.042261377,-0.009157141,0.032340147,-0.014573261,-0.0916514,-0.09224143,0.018185398,0.06037034,0.08378315,0.035483394,-0.03880278,0.026189018,-0.04274729,-0.049319923,0.056289416,-0.040026788,0.012001879,0.006551904,-0.03994949,0.086178765,-0.12836614,-0.010012668,-0.025450032,-0.02712444,1.4476843e-33,0.02874205,-0.0306932,0.036673743,-0.03707774,0.041243386,0.037920944,-0.09977853,0.09145891,0.0041130874,-0.0011310561,0.034318775,0.005775734,0.019078322,0.015969133,0.016538244,-0.0338133,0.0053977305,0.06561357,0.026309252,-0.060455784,-0.046881255,-0.046817392,-0.097310394,0.03510142,0.04030833,0.11652993,0.011051305,0.059773248,0.013285273,0.07092174,0.08939876,0.05949342,-0.108991444,-0.030658053,0.124839626,0.01244782,-0.073526815,0.04833703,-0.0010056368,-0.02557461,0.032616563,0.07348343,0.0108258715,0.07292767,-0.053680047,0.033691417,-0.13237332,-0.041717373,0.023823256,-0.11094776,0.055256326,0.030379293,-0.0725094,-0.0053566135,0.03114084,-0.018860286,-0.011399303,0.043730676,-0.014301781,-0.057795566,-0.09722745,-0.09469326,-0.034822788,-0.015317876,-0.060460694,0.0005021258,-0.03145358,0.03616056,0.008803383,-0.009496753,-0.03224668,0.02422431,0.065043114,0.06457241,-0.099712044,0.00062500825,0.016725978,-0.051233146,0.064996146,0.031097487,0.03270556,-0.062527135,-0.05955815,-0.09431559,-0.031031042,0.0057754368,0.031514622,0.06304676,-0.03133192,-0.06884264,0.028923988,0.03681937,-0.029531522,0.012359215,-0.027206654,-2.1786262e-08,0.07475374,-0.09309383,0.07924091,0.09348488,-0.06330901,0.0384558,0.022989105,0.018810218,0.029904896,-0.052921012,0.015667295,-0.0134972455,-0.01059612,0.0038062392,0.014130116,-0.009370413,-0.042559396,-0.04810298,-0.029725838,0.0024118247,-0.094005585,-0.008211863,-0.03748944,0.035787035,0.023767896,-0.06994685,0.043496978,-0.018547008,0.08273467,-0.032370567,0.00959978,-0.012338238,0.006495733,0.06663251,-0.028097114,-0.0007460078,-0.0006301807,0.012166484,-0.020028066,-0.029103592,-0.0032978645,-0.0729199,-0.041254517,-0.005663115,0.0701421,0.00087370165,-0.023239307,0.088110246,-0.06496415,-0.032294445,0.04077601,-0.014460627,0.036051482,0.065959275,-0.09044475,0.031178648,0.04865233,0.03848878,-0.061045174,0.02685512,0.0041410434,0.04635635,0.053331763,0.02728515 +1.14.13.32,"A microsomal flavin-containing monooxygenase. A similar conversion is also carried out by some microsomal cytochrome P-450 enzymes [EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming)]. It is estimated that cytochrome P-450s are responsible for 70% of the activity.",384,0.99999994,-0.08308673,-0.021896467,-0.09769242,0.021109855,0.038462237,0.040668912,-0.02143828,0.08238605,-0.021357827,-0.0076066004,0.010291381,-0.002459837,-0.08079386,0.07008869,-0.034754302,0.057902787,-0.06426316,-0.005426259,-0.010321466,-0.013587919,-0.013037481,0.013233946,0.09921374,-0.012944577,-0.046358187,0.027758293,0.008517669,0.050841283,-0.010482354,0.0070472653,0.07873082,0.06407608,0.08029591,-0.046559867,-0.018885,0.07978006,-0.052090976,-0.08748658,0.015396678,-0.0034443408,0.049761757,-0.00084898685,0.0016961705,0.004872031,0.011268705,-0.0767931,-0.01853667,0.062760495,2.1284914e-05,0.04864877,-0.029425656,-0.04287539,-0.08492401,0.044761475,0.010134545,-0.045216348,-0.018398285,-0.0747171,-0.056233663,-0.040061828,-0.06901063,0.07622141,-0.028327094,0.0709481,0.0028966041,-0.0017770592,0.020590153,-0.08783975,-0.0012656207,-0.037172228,-0.027495608,-0.07583699,-0.02778301,0.0041445303,-0.12054722,0.04104974,0.030636195,-0.03395924,-0.0050280583,0.012630296,0.0049640425,0.010716833,0.010485377,0.064441495,0.035660293,-0.02763289,-0.039413705,0.08297401,-0.036946528,0.04299224,-0.04010011,0.021779474,0.03111474,-0.010684114,-0.029005317,0.035685353,0.03898942,0.066562176,-0.012974073,-0.03625102,0.005008203,0.021214277,0.03660988,-0.014977084,-0.04345078,-0.038402203,0.0149563635,0.083536044,0.009029762,-0.06705576,-0.024964608,-0.035244513,0.04728265,-0.045981202,0.036406018,0.071022086,0.008868074,-0.052694395,-0.040640417,0.097760744,-0.046003353,0.011296878,0.029292058,0.026268825,-0.002404532,0.04148844,-0.07584029,2.391179e-33,0.07929073,-0.044783976,0.02105032,0.014866434,-0.00536002,0.049733896,-0.020924632,0.025776083,-0.01317827,-0.030461513,-0.07083547,0.013772825,0.093973555,0.038117826,-0.03542168,-0.03464447,-0.027870294,0.0032937434,0.07084285,0.0039543025,-0.05832157,-0.036570303,-0.046978977,0.012616391,0.00694133,0.10465518,-0.05886885,0.025850367,-0.04416859,0.009528389,0.002734877,-0.09483804,-0.07999427,-0.03721553,-0.011502238,0.023411704,-0.06986125,-0.02962988,-0.072203055,0.0639814,-0.047314934,-0.06540042,-0.0050651277,-0.03687089,0.049911782,-0.051484697,-0.16855873,0.118497126,0.03173901,0.062287908,0.076419264,-0.011723683,0.05064341,0.026728122,-0.073351525,0.10062452,-0.02880805,-0.019595733,0.024052754,0.0338727,0.09116783,0.013086733,-0.031756077,0.059316613,0.043666214,0.03307158,0.033137165,-0.05907172,-0.048934672,0.09414572,0.009690643,-0.040963218,0.059726518,0.039518915,0.07393345,0.039244886,0.06658949,0.056110606,0.006915263,0.017028643,-0.0006236656,-0.024771165,-0.0015711616,-0.068979606,-0.032897104,0.0487715,-0.0028411914,-0.05306978,-0.032186236,0.033490404,0.040087685,-0.15424801,-0.017650267,-0.05818625,0.010443946,-4.110063e-33,0.018022629,-0.048294082,-0.074236274,-0.1537218,-0.060942255,0.09134235,0.044746753,-0.020273773,-0.008510171,0.08337188,0.036928043,-0.018609049,0.0158901,-0.08807762,0.00064005004,0.023143912,0.0005719584,0.040762268,0.08858051,0.05367751,0.053507976,0.026097598,0.030266546,0.04194562,0.022702463,-0.009852333,-0.023267461,-0.022374874,0.052430958,0.029339228,-0.12832877,0.067738056,-0.062071532,-0.03054142,0.014011931,0.0065498315,-0.019348608,0.03647643,-0.020645592,-0.02192981,-0.03462726,0.04744138,0.013328167,0.07828386,0.022703445,0.1289533,-0.11163822,-0.07364458,-0.03410542,-0.06157388,-0.050808042,0.09179708,-0.021684933,0.054773368,-0.0067437617,0.061910488,0.0016011337,-0.03190223,0.05263012,-0.06825807,0.0063834814,-0.06327645,-0.0067015104,0.0074210647,0.023924876,0.07669931,0.0024010243,0.03609428,-0.023610195,-0.026995478,0.0392683,-0.043018118,0.08698293,0.04872343,-0.087527424,0.020694885,0.0044295182,-0.010698948,0.03097985,0.0008240347,0.10123969,0.010305399,-0.0021187044,-0.057012733,-0.045543294,-0.15565705,-0.016924027,0.04018628,0.025641281,-0.008672783,-0.017248243,0.027257493,-0.08906828,-0.058115005,0.038985588,-3.748046e-08,-0.022668306,-0.026386015,0.056114532,0.019000143,0.024714408,0.10275292,0.020141138,0.0055910978,0.024517989,-0.01964653,0.041309044,0.016336352,0.036819506,0.026547836,0.020506319,-0.0023756104,-0.023181686,-0.016180763,0.0038229951,-0.036889512,-0.067206256,0.028603056,0.011123717,0.038021382,0.03350599,-0.030908164,-0.058261946,0.025273934,0.02797143,-0.023743015,-0.039194413,0.06324957,-0.036053706,-0.018103043,-0.093505375,-0.035594203,0.014419249,-0.02835445,-0.07860613,0.027921911,-0.10287114,-0.10041133,-0.009405946,-0.0002921627,0.04982927,-0.001199006,0.048284464,0.03988393,0.0037594878,0.006665623,0.050677232,0.0006634883,-0.02407435,-0.06626149,-0.1154245,0.005408157,0.048204675,-0.082547836,-0.038648374,-0.063851506,-0.019501233,0.0358819,0.17039034,-0.021201473 +1.14.13.33,"A flavoprotein (FAD). The enzyme from Corynebacterium cyclohexanicum is highly specific for 4-hydroxybenzoate, but uses NADH and NADPH at approximately equal rates (cf. EC 1.14.13.2 4-hydroxybenzoate 3-monooxygenase). It is less specific for NADPH than EC 1.14.13.2.",384,1.0,-0.09317843,-0.06181448,-0.114336655,-0.036850248,0.060445778,0.03855946,-0.04637443,0.09280589,0.053910777,-0.04182688,0.01258181,0.00672935,-0.0844243,0.02393841,-0.0794849,0.05511587,0.0028929517,0.00941062,-0.03192768,-0.03127519,0.016769057,0.015513665,0.09663174,-0.0016539756,0.06170781,-0.016428318,-0.013118781,-0.015946176,0.012741435,-0.0051995604,0.07874087,0.069048174,0.012311496,-0.017478488,-0.00261308,0.05471663,0.008689018,-0.052315187,0.013710632,0.036199007,0.022068674,0.025456337,0.02685594,0.00075827393,-0.0074777515,0.01631248,-0.016218022,0.06868028,0.039884288,0.013023523,-0.006173623,-0.08801439,-0.07992005,0.04760961,0.038171068,0.011838081,-0.017171117,-0.053512614,-0.00075030315,0.0014402427,-0.020582842,-0.06579243,0.02424934,0.050808344,0.0134664,-0.016295223,-0.055341747,-0.0657668,0.0308251,-0.07729375,-0.07595817,-0.021487929,0.011432137,0.06934941,-0.022530967,0.05911747,-0.08551056,-0.05072059,0.041098148,-0.028957246,0.054851968,-0.011050729,0.023851393,0.06468024,0.082135655,-0.021077458,0.031065399,-0.014701231,-0.01208829,0.05125505,0.0324778,0.0361821,0.034559127,0.0032483137,-0.12154025,0.052016463,0.11576799,-0.007111751,-0.014047477,-0.014773198,0.024400963,0.052408647,0.021081744,-0.028106885,-0.09624399,-0.06311283,-0.03194921,0.09048791,-0.052014656,-0.028243344,-0.03205034,-0.01725465,-0.0009109179,-0.107310355,-0.019730084,0.0071369084,0.020646015,-0.05463736,-0.02630762,0.00047996527,-0.06727304,0.04744094,0.059910614,0.051028263,0.07532006,0.031039905,-0.12842584,3.2703803e-33,0.105878554,0.031638745,-0.0273745,-0.018458387,0.029627329,-0.018464155,-0.06735545,0.0294182,0.009912686,-0.058722746,-0.063533396,0.009760939,0.027415216,-0.07595379,0.038760636,0.05939256,-0.07342469,-0.049291436,0.048193578,-0.060081795,0.06644962,0.02492522,-0.012955829,0.07378916,-0.010345815,-0.04193161,-0.047914084,0.07697206,0.018153999,0.03124905,-0.044529848,-0.09188046,-0.09098549,-0.03482229,-0.013783473,0.03290844,-0.09148278,-0.10983123,-0.06801924,0.06817341,-0.032841284,0.011329798,0.022464495,-0.016764978,0.06532739,-0.07133979,-0.070606425,0.10387553,-0.006360164,0.080218874,0.04083069,-0.052369956,0.1377089,0.03989611,-0.05506489,0.039322462,-0.041669577,0.010693161,0.008064736,0.04769156,0.02868624,0.06799438,-0.048292197,0.09259523,-0.09431066,0.014007792,-0.04602245,-0.051816426,-0.003586447,0.11019543,0.045143917,-0.023848759,0.08300261,0.011326019,0.08528108,-0.065645464,-0.010604147,-0.080681376,-0.013867962,0.004630083,-0.017822467,-0.03480381,-0.03378598,-0.02184433,-0.06688079,0.02111871,-0.0022727915,-0.018559014,-0.01594411,0.020194108,0.07433377,-0.09324958,0.027379237,-4.3272652e-05,0.015269083,-2.5952428e-33,0.08387373,-0.040923,0.055172913,-0.045341004,0.05773486,0.027455581,0.091544926,-0.03772991,0.03804274,-0.0769411,0.072429426,-0.014027683,0.018396217,0.020940388,0.027220627,0.020378022,-0.05520697,-0.0019326654,0.04973194,0.032168888,-0.042740256,0.020832708,0.060012255,0.03780248,0.044567447,-0.05530161,-0.023214517,0.0042246655,0.0035321894,0.041550945,-0.06365922,0.05710452,-0.058041077,0.0003972206,-0.08646454,0.03668316,-0.04141163,-0.012128661,-0.005841715,0.04081465,-0.009431642,-0.00652863,-0.0741506,0.057538804,0.051497884,0.052353002,-0.08144457,0.015915338,0.09839276,-0.062434774,-0.015486371,0.025787892,0.019317882,0.05415519,0.04734083,0.045849442,0.013114005,0.06005495,-0.00742624,0.030089846,0.023550076,-0.09709839,0.023684496,0.033942595,0.0840641,0.06333146,-0.010012628,0.09188031,0.002126588,0.04345997,0.08981703,0.011164024,0.007504432,0.051462386,-0.0035396842,-0.024448968,0.01050752,0.06701253,-0.074833184,0.00035186633,0.03078029,0.015456285,-0.02177809,0.035521723,-0.088362366,-0.06270784,0.020921169,0.057805244,-0.037767507,0.027238986,-0.025003418,0.0735708,-0.014828281,0.008396507,0.048420567,-3.748633e-08,0.0043216115,-0.028817806,0.016630104,-0.03989733,0.1026345,0.063040994,-0.03487567,-0.015938614,0.01820931,-0.047254257,-0.033181574,0.14723109,0.0051666484,0.046631485,0.0509916,-0.015303632,-0.069569185,-0.008306264,-0.023181617,-0.017532205,-0.06571062,0.053630207,-0.08695924,0.035411872,-0.073801465,-0.012943745,0.01651698,0.002357194,0.007374088,-0.0316436,-0.006375795,0.020346489,0.007752555,-0.06398867,-0.088632934,0.06801191,-0.014385092,-0.015650043,-0.046328463,0.078431256,-0.040227197,-0.058146875,-0.057740543,-0.0145178335,0.021762425,-0.018533783,0.03807435,-0.0041453512,-0.036374282,-0.006784861,0.044583246,-0.0369127,-0.026095808,-0.04020141,-0.022591058,-0.006324837,-0.043527056,-0.10557989,-0.0773123,-0.10206499,0.02962895,0.003006978,0.14901532,0.008372545 +1.14.13.34,"Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.14.94, leukotriene-B4 20-monooxygenase.",384,0.99999994,-0.06883232,0.006861091,-0.04029929,-0.0069758454,0.09234479,0.061011836,-0.07987603,0.027129622,0.060740475,-0.07609596,0.054611526,-0.042792108,-0.014209932,0.02558883,-0.035353243,0.07589832,0.001247587,0.001776205,-0.08197703,-0.10366049,-0.04332232,-0.015480571,0.0050904574,-0.06102671,0.040407922,-0.018027822,0.02412256,-0.011585445,0.004424786,-0.05372792,0.054778107,-0.016183337,0.020267412,0.017413508,-0.031158403,0.056314263,-0.024352616,-0.027882421,0.030091314,0.057616357,0.046922017,-0.035229027,-0.051818743,-0.06086986,-0.0018546955,-0.048127696,-0.031087054,-0.021595055,0.019744517,0.02912444,0.012029179,-0.0011283287,-0.034366067,-0.017027529,0.04974306,-0.012276131,-0.14826909,-0.017027553,0.023282247,0.04525756,0.00681521,-0.054775696,0.055800628,0.050104916,0.026697299,0.028542142,0.07877193,-0.106345266,-0.0371456,-0.04367285,-0.018825611,-0.038928732,-0.050567083,-0.0015036187,-0.038424592,0.037831847,-0.091774635,-0.047935445,0.018463127,-0.06432178,0.024856953,0.0452549,0.0029633206,0.023004793,-0.013893871,0.0052704117,-0.0017717147,-0.042173453,-0.041882973,0.05044606,0.0357361,-0.030256303,-0.005616518,0.056005064,0.017926665,0.015060257,0.083318494,0.04777151,-0.03773078,-0.0038595025,-0.086741336,0.09868749,-0.09180789,-0.023441836,-0.05882486,-0.010961773,0.0697605,0.035533942,-0.054929316,-0.0033574132,0.04782353,-0.07036109,0.02433319,0.012039594,-0.0039426656,0.073990166,0.0066810423,-0.074696034,-0.03789859,0.060453437,0.047502942,-0.05149516,0.016305465,0.03771381,0.012788359,0.11936166,0.014106901,1.5691613e-33,0.068218365,-0.00556212,0.031060422,0.016827388,0.024213204,0.013615521,-0.06556472,0.045681756,-0.024116535,-0.048575103,-0.010310888,0.017922819,0.0634976,-0.0025544628,-0.097724885,-0.014853041,0.034721326,-0.022430182,0.03729536,-0.013347047,0.026661247,0.0027237516,-0.04016258,-0.021749968,-0.08023199,0.0073502185,0.017328024,0.033316374,0.046240296,-0.0030586268,-0.033346027,-0.036795508,-0.07344253,0.0019154975,-0.02192251,-0.002060378,-0.019417692,-0.035548296,-0.008682746,0.020347256,-0.010117937,0.069276296,-0.08449278,-0.12005098,0.04920579,-0.043075748,-0.078984365,0.08423483,0.038200166,0.08239165,0.047924407,0.028441343,0.061831318,-0.04057769,0.00646426,0.00487208,-0.061500225,-0.020857338,0.01801716,0.054746315,0.05719743,0.015674638,-0.06389107,-0.012517645,0.085573405,0.07440971,-0.063683085,-0.085523106,-0.07096218,0.007560828,0.038456634,-0.032724142,0.13126653,0.040012825,0.06138717,-0.022937184,-0.046603125,0.04643624,0.022511374,0.0339052,-0.024991877,0.07094793,0.036363184,-0.06127359,-0.043592103,-0.04579553,-0.017591525,-0.09231628,0.048639525,0.0009146325,0.07771036,-0.0924343,-0.105907924,0.04098289,0.029661538,-3.3790526e-33,0.026515644,-0.044469763,-0.022971347,-0.012853251,-0.023145467,0.13473667,0.057643726,0.025241816,0.039910443,0.120639265,0.20242538,0.0055792322,0.019423325,-0.035654005,0.079040684,0.0064394595,-0.019206386,0.041328732,0.01826514,0.042468507,0.025798922,0.03591973,-0.0038706705,0.11374101,0.08649833,0.041783273,-0.009345661,0.018768433,0.007752128,0.031564966,-0.033146568,0.027022328,-0.09013691,0.032061424,0.009474738,0.05357541,-0.04059155,0.029786937,-0.039341502,-0.05339861,-0.06377648,-0.015735045,0.06016095,0.053956546,0.07850061,0.055067252,-0.062615044,0.031440366,0.029332004,-0.05051768,-0.013879995,0.09194984,-0.04982784,0.025673559,0.032483764,0.1002656,0.019150933,0.0019661882,0.031066336,-0.067384794,-0.045185335,-0.079750106,0.019794026,0.019503193,0.015974483,0.007235533,-0.0757856,-0.00884504,0.0761298,-0.013098308,0.04754671,-0.06257649,0.03635031,-0.055841535,-0.010026421,-0.012607655,0.015722163,-0.124395095,-0.0828757,-0.034255113,-0.041214637,0.0076467237,-0.0061716246,-0.071271665,-0.09865943,-0.050557602,0.018743502,0.051741745,-0.009526134,0.057876967,-0.016471313,-0.0062778494,-0.13128915,0.013404306,0.037641816,-2.97782e-08,0.018191889,-0.024477333,0.101063944,-0.026473094,-0.0032568765,-0.021814264,0.01788335,0.038602777,0.04488941,-0.024885418,-0.010418914,0.080205895,0.045456223,0.005838693,0.06904885,-0.004028151,-0.026144164,-0.018312315,-0.0011997217,-0.019305749,-0.051284757,-0.030482344,-0.00055971247,-0.056985635,-0.05442233,-0.103196226,0.04147723,0.04605836,0.009704357,-0.08651713,0.0148508875,0.010597185,0.02973408,-0.054466855,-0.052936487,0.015453953,-0.0026171114,0.03110377,0.007098168,0.047304835,-0.080667466,-0.101491675,-0.039282437,0.004453912,0.051399846,0.034528453,-0.0031690276,-0.05531645,-0.027403295,-0.037058014,-0.017142992,-0.07075452,-0.017108023,-0.05645931,-0.02431373,0.024269268,-0.027916558,-0.100178674,0.12367526,-0.04379566,-0.059202246,0.006935657,0.09282663,0.04405796 +1.14.13.35,The enzyme from Aspergillus niger is an iron protein; that from the yeast Trichosporon cutaneum is a flavoprotein (FAD).,384,1.0,-0.054883704,-0.054443657,-0.14724489,0.038837686,0.1428994,-0.0061423997,-0.019240638,0.040476613,-0.018319197,-0.06665153,0.029920042,-0.040140774,-0.12599495,-0.012867431,-0.09393509,-0.021738693,0.019894576,-0.02104927,-0.0030108714,-0.043501858,0.045293283,0.07301213,0.03921226,-0.010834808,-0.01802377,-0.021731092,0.06956555,-0.051239647,-0.03684927,-0.03342705,0.015411283,0.011123539,0.010788306,-0.011731299,-0.0056534596,0.06299501,0.03706741,-0.009493599,0.027217215,0.010523574,-0.0057714963,-0.026818192,0.03665607,-0.05585415,0.027790856,0.027920965,-0.013349222,0.0678347,0.073654,0.07129748,-0.047901805,-0.03291566,-0.091737695,0.030029725,0.026637087,0.014136562,-0.027143016,-0.09547646,-0.055917226,0.05742542,0.012837363,-0.075430416,-0.024104621,0.010243828,0.05078004,-0.030260362,0.042908974,-0.050135553,-0.011209407,-0.08511293,0.026326094,-0.010551049,-0.075421385,0.009027503,0.0015763877,0.096856326,-0.0068843747,-0.0429467,0.076558314,-0.041311372,0.053940807,0.039271444,0.12649322,0.0483746,0.016802547,-0.03799589,-0.014414717,0.016747475,-0.024888732,0.045842543,0.05177229,0.07405556,0.030150747,0.030172091,-0.038678806,0.082686,0.021885969,0.04282162,-0.04292122,-0.012386019,-0.041082773,0.0061403955,0.01808582,-0.040014308,-0.02174561,0.0013800461,0.0038023107,0.10227566,0.043284737,0.0099299345,0.009540938,0.03792192,0.030372988,-0.07032276,0.036137085,-0.016626135,0.043201696,-0.05489257,-0.020640625,0.04059407,0.009429894,0.11824412,0.00021465932,0.06955262,0.00096831727,0.01412487,-0.06600734,1.31354165e-33,0.051748216,0.071665995,-0.057818364,-0.03686639,-0.009821469,0.005215807,-0.09195428,0.0022222104,-0.060927104,0.006556988,-0.03797666,-0.05354765,0.011453939,-0.005802566,-0.016691452,-0.02908154,0.018466484,-0.0567722,0.052875362,-0.013942945,0.028145703,0.11255868,-0.011658991,0.033460323,0.056931484,0.010091019,-0.09015065,-0.0076089273,-0.012552568,0.011389771,-0.018471265,-0.11288537,-0.07786371,-0.032320432,0.05487749,0.0006333626,0.012886577,-0.08068891,-0.14215465,0.016217533,0.042361505,-0.015171377,-0.053353023,0.0010894212,0.008432429,-0.0628113,-0.075272575,0.08270756,0.0033604754,0.06633166,0.013536775,0.00860467,0.11759548,0.04220671,-0.07965777,0.008270236,-0.03399508,0.055406604,0.06595049,0.014123746,-0.0068412093,0.07697737,0.0066705896,0.13055669,-0.031371254,-0.05514657,-0.04180726,-0.005177664,0.074156314,0.06336993,0.00035767432,0.02104853,0.0435249,0.021456717,0.028181685,-0.10502062,-0.07091732,-0.0825255,0.03202368,0.024715405,-0.022437003,-0.031182002,-0.021692676,-0.07471629,-0.15251254,0.08129422,-0.018379265,0.018405033,0.011745301,-0.10076296,-0.00485879,-0.044732418,-0.029015277,0.0044908705,0.042203594,-1.6800402e-33,0.050941397,-0.0812539,0.03313869,0.0044012554,-0.029816061,0.055688318,0.039563596,-0.029966611,-0.02161473,-0.037163354,0.12713513,-0.08939329,-0.031559106,-0.036673322,0.048821278,0.05608529,-0.05771649,0.022564646,0.0758374,0.013047203,-0.1022793,0.020384004,0.016245663,0.06517992,0.014593129,0.04089205,-0.018736072,-0.03989746,0.02470274,0.08614595,-0.039236248,0.053702857,-0.018388592,-0.025095914,-0.06998353,0.05596475,-0.009414033,0.041487183,0.009359673,0.007767543,0.020850785,0.030939728,-0.046612352,0.08900658,0.011841628,0.07538243,-0.026223352,0.054255303,0.027872639,-0.047834497,0.017852342,0.01987377,0.0120450845,0.024032677,0.047883805,-0.021331172,0.0634381,0.012208333,-0.03203919,0.03296479,-0.038247596,-0.06900104,0.030443849,-0.0045865495,0.1684484,0.083030105,-0.050598923,0.033199567,0.034103565,0.0006460258,0.07296943,0.046566427,0.04162046,0.041457325,0.0096876705,-0.040220033,0.029923879,0.057312194,-0.05292931,0.048404384,0.05252238,-0.059432168,0.017609809,0.05623873,-0.07579509,-0.12603728,0.047708206,0.06105901,-0.043956365,0.008823751,-0.067694746,-0.016906668,-0.029769389,-0.009434588,0.010831112,-2.7928172e-08,0.04624696,-0.016223686,0.032304734,-0.07385813,0.0587794,0.049389165,-0.001048214,-0.06503864,-0.027153654,0.008122869,-0.065530196,0.083657995,-0.027320698,0.051257383,0.045616243,-0.03558277,-0.0011084764,0.051351607,0.022681916,0.021592535,-0.01599493,0.01675795,-0.07484785,-0.020118104,-0.049434695,-0.018102463,0.012035982,-0.019616736,0.06486112,0.030965721,-0.10117968,0.030464325,-0.002481148,-0.028516408,-0.0762126,0.022206387,-0.010104012,-0.053750094,-0.044721935,0.02677642,-0.061866723,-0.016625803,-0.028865194,-0.06649144,-0.066073634,-0.08260084,0.057526004,0.023762263,0.012155618,-0.002680107,0.033356488,-0.023350535,0.024835156,-0.0073811314,-0.06506176,-0.008517472,0.006939456,-0.07715575,-0.025893174,-0.07695181,-0.018968608,-0.044269364,0.09985088,-0.043750107 +1.14.13.36,Also acts on trans-5-O-(4-coumaroyl)shikimate.,384,0.99999994,-0.029191967,-0.031696573,0.0021776797,0.03716971,-0.023530105,0.04228418,0.005286072,0.0034428015,0.05749837,-0.0072449483,0.050855897,0.010043839,-0.04511151,0.035245813,-0.011264996,0.07086165,-0.07003759,0.071379706,-0.05065204,-0.06457361,0.033775292,-0.060566913,0.013115166,0.012326221,-0.04956793,-0.025182782,-0.030144751,0.008988835,0.053783935,-0.13725264,0.00031651513,0.08339658,-0.085083604,-0.016168155,-0.112610474,0.05735584,-0.033636842,-0.040519916,0.009181549,0.12384396,0.06261548,-0.047673468,-0.0059734485,-0.074570045,0.017156472,-0.007389093,-0.073609255,-0.010794887,0.048276387,-0.026614675,-0.07345463,-0.0581892,-0.055417094,0.06413853,0.005768983,-0.07208142,-0.09646877,-0.07877078,0.05335875,0.047966428,0.019642008,0.037962254,-0.020203205,0.013567957,-0.033686645,0.021379987,-0.01577631,-0.039417114,-0.013661974,0.0037590864,-0.012462297,-0.05395417,-0.011013024,0.03214998,-0.064604454,-0.0026652187,-0.0235378,-0.038416445,0.012734317,-0.033060975,-0.027219107,0.05149967,0.070422575,0.02964847,0.033938445,0.007584568,-0.017925125,-0.027521657,0.0013884648,0.049141504,-0.004943972,-0.023662966,-0.0055144243,-0.02765291,-0.008666214,0.012437133,0.036224827,0.05585405,-0.01788043,-0.021291729,-0.0214741,-0.004826534,-0.087360665,-0.042922314,-0.09235501,-0.05068308,0.027965555,0.07237682,-0.03359003,-0.018322526,-0.033558946,-0.07244092,-0.019775707,-0.07872795,-0.089452654,0.076439865,-0.05355341,-0.030664146,-0.023081366,0.0400973,-0.016384928,0.017809283,0.0069092116,0.09633278,-0.02378778,0.03473421,-0.007094763,-2.5493644e-33,0.08176732,0.07244857,0.010786343,0.062549315,-0.0513016,-0.05866355,-0.090217605,-0.102039896,-0.03415139,-0.068373404,0.007163863,0.028584812,-0.0164885,0.00864178,0.021571686,-0.036158536,-0.011345164,-0.016775433,-0.014801293,0.0027616867,0.059753716,0.16881701,-0.077034935,0.005154304,-0.03541987,0.07492956,0.014642899,-0.067857906,-0.005166532,0.03356317,0.008003457,0.0047490955,-0.019201316,0.030344673,0.032442454,0.07475347,-0.054453682,-0.02268533,-0.07188797,0.035587683,0.13653795,-0.051833365,-0.09603723,0.051802613,0.07203548,-0.031202074,-0.07161454,0.008993653,0.025332278,0.048807215,0.005961508,0.106313534,0.04343636,0.029784767,-0.04145963,-0.038145375,0.019746954,-0.013439191,0.033992164,0.100887164,0.0023956767,-0.00174847,-0.02566024,-0.016801108,0.00800779,-0.03842697,-0.014900066,-0.03616858,-0.020200634,0.058789812,-0.02384153,-0.01577768,0.11766454,0.11252865,0.076124325,0.00181801,0.007029067,-0.014737401,-0.00079343974,0.055519465,-0.052001093,-0.05248007,0.039513726,-0.011234764,-0.04285125,-0.005874256,0.043429524,-0.053728808,-0.06957785,0.0054372926,0.06420719,0.004857267,-0.00044709886,-0.014127054,-0.035170272,6.7155887e-34,0.010631317,-0.04962119,-0.017001115,0.06110826,-0.09910603,0.072145335,0.026076952,-0.0028935147,0.024487311,0.083083026,0.17464633,-0.0045818374,-0.02444831,-0.01754595,0.021611245,-0.008930466,0.027985618,0.10440232,-0.0351191,0.01252683,0.001770947,0.09046256,0.009150869,0.096358575,0.059214536,0.14609458,0.026200658,-0.054364424,-0.029018665,0.029071033,0.02103348,-0.07280661,-0.01932958,-0.008718271,-0.049827877,0.016552765,-0.015440256,0.045982417,-0.0790424,-0.02352753,0.0097982,-0.060086533,0.10025289,0.10917433,-0.007590993,0.012970062,-0.023629183,0.07380855,-0.011229644,-0.015159329,0.037908837,0.0082752025,-0.027955871,-0.030969735,0.015624299,0.0013965445,0.01718431,-0.07697497,-0.03394373,0.014163476,0.0036965506,-0.010293992,0.06068021,-0.06920065,0.045808326,0.027559998,0.018575322,-0.04920789,0.045723885,-0.04715718,0.020696573,-0.0029023418,0.019472055,-0.029549701,-0.028934566,-0.043220054,0.04376344,-0.057971545,-0.0055150976,-0.014201986,-0.08997628,-0.07396423,0.012852506,-0.057267915,-0.011926491,-0.026048217,-0.03009062,0.056743745,0.09231152,0.057205904,-0.047898397,0.037004407,-0.0390719,0.0015704489,0.0025298109,-2.3203388e-08,0.07333266,-0.031908736,0.013057008,0.011760664,0.030212818,0.030923942,-0.037723493,-0.050400566,-0.0050644074,0.0314327,0.035860233,0.077639505,0.02612855,-0.0050907917,0.10093941,-0.046102297,0.042844843,0.075482674,-0.020876,-0.07638264,-0.15415743,-0.041614182,0.033696767,0.010121927,-0.06514575,-0.032237515,0.04685987,0.053992316,0.067080826,-0.044682425,0.060796842,0.012633074,-0.03429964,0.02215802,-0.03097269,0.03848481,-0.0016828614,-0.002760465,-0.06510904,0.09666038,-0.031270802,0.0024782892,0.004091132,0.054799173,-0.05532564,0.016642416,0.0044335406,-0.08261806,-0.010038499,0.009585768,0.038309846,0.008083407,0.01225625,-0.010554125,-0.15919274,0.036147356,0.030504903,-0.110640295,0.034035306,-0.073709704,0.0026966748,-0.03833981,0.11117228,0.067530505 +1.14.13.37,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.14.13.38,"The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. It can also catalyse EC 1.14.13.234, 12-dehydrotetracycline 5-monooxygenase.",384,1.0,-0.06631211,0.03945622,-0.1614478,-0.03561983,0.03954308,0.018572979,-0.06879697,0.0411998,0.081430554,-0.030434621,-0.028340409,-0.094571985,-0.0013265782,0.038878884,-0.07625362,-0.037851088,-0.085041516,-0.0012983457,0.025817983,-0.10183442,0.025164004,0.07972033,0.014151542,0.013597085,0.015880857,0.04489667,-0.0040900144,0.031891767,-0.06662472,-0.03943093,0.070702255,0.0014819942,0.054615177,-0.064118534,0.043644056,0.089570925,-0.08362978,-0.035897065,0.11143891,0.0030063388,-0.04990096,0.0023000003,-0.025786983,-0.025086958,-0.03671388,-0.0032512646,0.069766276,0.07314861,0.033817735,-0.021800917,0.017803205,-0.031796526,-0.06255488,0.05823981,0.047403343,0.055857193,-0.00082570734,-0.01615705,-0.00020311188,-0.048915405,0.077445984,-0.008519632,0.03747256,0.07647904,-0.0866465,-0.021027474,0.029888954,-0.11232197,0.0021208217,-0.04526243,-0.07312981,-0.0698583,-0.00046929508,0.035641517,-0.025224907,0.028502325,0.027419118,-0.058458555,-0.024099767,0.020200564,-0.013434716,-0.047526184,-0.024509493,0.051511593,0.05426549,-0.06799273,0.0423422,-0.009277456,0.04922949,0.04133152,0.059586644,-0.028306479,0.026439326,-0.04650813,-0.043530516,0.011997234,0.007117396,0.011077258,0.0198473,-0.029868588,-0.069257006,0.04427413,-0.046621356,-0.026562994,-0.03251448,0.041171137,0.031660955,0.054078538,0.015239104,-0.066536546,-0.016828688,-0.058664586,0.041267987,0.008270403,-0.0105833,0.074026346,0.039356288,-0.10111981,-0.032115843,0.058752596,0.03367501,-0.020455211,0.00518662,0.04583624,0.0112871,0.07077378,-0.10216897,2.2747101e-33,0.0013718489,0.04770154,0.019505454,-0.06356184,0.07592899,0.010357365,-0.022033736,0.024889769,-0.022127414,-0.03433512,-0.08387063,-0.042736184,0.08785664,0.027256565,0.008666939,-0.013361316,-0.014891542,0.043577082,-0.003637092,0.03597115,-0.028147353,0.011000306,-0.06424925,0.022147503,0.053574547,0.09783277,-0.010238359,0.016181715,0.10516072,0.0066564726,-0.041066263,-0.06577272,-0.08518274,0.006723235,0.07228177,0.0070891385,-0.06657962,0.006081907,0.046633877,0.059754442,0.02998857,-0.00053260825,-0.02284104,-0.010780537,0.038356606,-0.035030007,-0.043646492,0.107314534,0.06645219,0.06763571,0.049212936,-0.020198742,0.07506534,-0.048666988,-0.029462563,0.07527761,-0.051254384,0.065258734,0.050653905,0.046802644,-0.043118544,0.03334679,-0.05464313,0.012057158,0.013489362,0.028427415,-0.030018242,-0.04855302,-0.034552366,0.029430987,-0.085714325,0.072482854,0.07847457,0.029466596,0.039024655,0.045427855,-0.026590953,-0.0422968,0.10928938,-0.0030769242,-0.04257777,-0.00062404247,0.035169296,-0.08335717,-0.021927537,0.008824483,-0.07933464,-0.052106738,-0.01723279,0.10582259,-0.0036492662,-0.09147324,-0.12523994,0.0067791212,-0.036508407,-4.199866e-33,0.05589973,-0.07797485,-0.010516088,-0.1009404,-0.037146095,0.11029032,-0.03503163,-0.07185194,0.018298015,-0.034629412,0.08083462,-0.025097137,0.0217273,-0.062435523,-0.016345149,-0.033642292,0.024414713,0.08548821,-0.011765327,0.020865196,0.09357073,0.024481514,-0.03383402,-0.035411336,0.029286828,0.009414903,-0.050037984,0.050714552,0.08770327,0.060816314,-0.041881625,-0.040867306,-0.020564543,0.013479643,-0.017579345,0.15358967,-0.08075941,-0.025693549,0.08914612,0.028302426,0.06416008,-0.0010787457,0.033224013,0.07558946,0.03901088,0.055160683,-0.0981246,0.050202664,0.012884911,-0.06699411,0.017713655,0.036537208,0.022253986,0.037316617,0.036121998,0.015270646,0.035975665,-0.031974237,-0.022164008,-0.063122146,-0.028107336,-0.04855601,0.037429404,0.03173193,0.024391694,-0.013490926,-0.08199992,0.022463258,0.043347295,0.002303258,0.06520874,-0.049422357,-0.039508548,-0.014987813,-0.044232607,-0.038233988,-0.062243346,-0.036555897,0.019586762,-0.028255755,0.011029201,0.04460521,0.034248736,-0.08878234,-0.019682515,-0.066488236,0.009900115,0.039766032,0.041715898,0.042871274,-0.045290485,0.01794122,-0.053861596,0.011618913,0.10436295,-3.294909e-08,0.04567386,-0.044966627,0.08112549,-0.0041819587,0.06681607,0.019528376,0.009248737,-0.033073626,0.013076346,-0.058703326,0.027757563,0.021319993,0.01988599,-0.021806609,0.001592141,0.045425486,-0.06061824,-0.058473643,0.029926421,-0.035097875,-0.06817314,-0.002079729,-0.07239447,-0.00921219,0.006671876,-0.043268446,0.0061730747,-0.0009364587,-0.059992548,-0.030591235,-0.021797907,0.015417316,-0.05585186,-0.016305951,-0.07849326,-0.044311184,-0.08616316,-0.019530054,-0.01697557,-0.00575788,-0.016020095,0.019557504,-0.114897,0.0100391265,-0.024768589,0.04017636,0.0013228125,-0.01094958,-0.07090314,-0.052448824,0.07034762,-0.00820775,0.015004173,0.018508995,-0.0632239,0.052344438,0.0045386893,-0.062014006,-0.059858795,-0.02917278,-0.019370448,0.040077772,0.20533445,-0.037822474 +1.14.13.39,"The enzyme consists of linked oxygenase and reductase domains. The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin, and its two domains are linked via a regulatory calmodulin-binding domain. Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. The reductase domain of the enzyme from the bacterium Sorangium cellulosum utilizes a [2Fe-2S] cluster to transfer the electrons from NADPH to the active center. cf. EC 1.14.14.47, nitric-oxide synthase (flavodoxin).",384,1.0,-0.05790031,-0.074203394,-0.17871067,0.06870562,0.116427466,-0.00044131879,-0.05757099,0.050499674,0.04513861,-0.11442475,0.03271678,-0.03094521,-0.043430746,-0.0045319805,-0.05772306,-0.056988306,-0.044362728,0.010330861,0.005122285,-0.030850485,0.047509283,0.01923666,0.01999044,-0.050661847,0.0034467091,0.014230391,0.005685125,-0.017303316,-0.011579867,-0.04164375,0.013381114,0.0010691194,-0.010635429,-0.053384393,0.0055933846,0.07514441,0.0056871297,-0.060309228,-0.020008603,-0.047274187,0.061226834,-0.00885093,0.03610069,-0.027050605,-0.026814433,0.0143948,0.05058113,0.06877848,0.022097694,-0.0028023089,-0.06007492,-0.032656915,-0.009169235,0.06321992,-0.0067432877,0.04754583,0.055890527,-0.008974561,0.06711778,0.008492253,0.005695627,-0.043502998,0.038340077,-0.010031454,0.05487708,-0.071683936,-0.0058803004,-0.045508478,-0.09247307,-0.0909496,-0.052574176,-0.00853292,-0.003918253,-0.008964927,0.0074187093,0.06328795,-0.0414821,0.0017214238,0.0482639,0.031687453,0.043366577,-0.008186936,0.049955573,0.11305727,-0.025594892,-0.00723577,-0.028105568,-0.0071476395,-0.023084346,0.02837217,0.07900072,0.013654703,0.020246584,0.02164018,-0.09704148,0.037597887,0.046465073,0.07413065,-0.0029239391,-0.049740743,-0.031598702,0.054372396,0.0006402811,-0.06953322,-0.012881382,-0.041906185,-0.005210073,0.11031256,0.054335747,-0.008903058,0.046022996,-0.023918752,0.03146339,-0.040835634,0.012588356,0.068874106,-0.014202419,-0.033687126,-0.08066251,-0.06852706,0.012880315,0.028910503,0.00083207147,0.07043332,0.055841956,-0.03936253,-0.17499273,3.1258257e-33,0.10659756,0.0069994926,-0.042747177,0.038138643,-0.025150409,-0.034400377,-0.026115885,-0.043711506,-0.0066871797,0.037660334,-0.06012654,-0.023695527,0.05224178,-0.036172338,-0.008903842,-0.0762136,-0.02381166,-0.08960885,0.057147942,0.04450379,0.07028282,0.025557956,-0.033503152,0.05549921,0.0525844,0.091166906,-0.083021335,0.037661564,0.038626965,-0.0064540217,0.0682723,-0.08996281,-0.13112712,0.00054567226,0.13196282,-0.033156812,-0.02694698,-0.003268511,-0.06632125,-0.003070058,-0.030098666,0.032524094,-0.05760158,0.006534128,0.10908759,-0.04454699,-0.041089423,0.111340106,0.07959659,0.0942221,0.024830185,-0.039371215,0.12415988,-0.019821035,-0.0689502,0.040502686,-0.036708396,0.025718471,0.015401101,0.067130916,0.0121056745,-0.0036381478,-0.039001882,0.07103172,-0.012585144,0.115786694,-0.014546138,-0.08756885,0.05239886,0.06456026,-0.03438027,0.05515473,0.056721557,0.04387099,-0.0017850195,-0.0052750064,-0.06337925,-0.026708582,0.05380728,-0.04064521,0.051443182,-0.0041070315,-0.06937522,-0.01767959,-0.044498246,-0.049050834,-0.08885005,0.005857675,-0.0701586,0.004402138,0.11184435,-0.063484915,0.04277584,-0.023316871,-0.0012807788,-3.3477407e-33,0.12035948,-0.09883087,0.037837107,-0.09425866,-0.024954835,0.06197875,0.053861734,-0.036620017,0.02076464,-0.0030700285,0.06548754,0.022158882,-0.051078655,0.006112527,0.024000986,0.04817157,-0.021376573,0.06743459,0.03933821,-0.04073777,-0.033868086,0.009405908,0.018588884,0.035988986,0.016067248,0.05050426,-0.04467325,-0.019349787,0.013649277,0.028895613,-0.056861833,-0.021988835,-0.07654522,-0.035697054,-0.009424978,0.013241547,-0.054996364,-0.016674744,0.04009123,-0.012995229,0.03816543,0.0009187717,-0.017604014,0.07941619,0.0699887,0.06982324,-0.13718171,0.024938967,-0.07411815,0.0059567373,-0.009309742,0.0046282876,-0.008382376,-0.029761018,0.036149446,0.0024528997,0.1028735,0.04326919,0.0010992612,0.006586557,0.0010854773,-0.08722175,0.009372423,0.061753623,0.008495154,0.04161498,0.0415422,0.05685692,0.011361898,0.01973081,0.06608103,-0.020355742,0.047611836,-0.0007509542,-0.04484305,-0.024758367,0.04547396,0.048337363,0.023513814,-0.008656779,0.004357823,0.025094688,0.0009638797,-0.08486035,0.039280333,0.015411984,0.050671123,0.057033166,0.029736383,0.0020356795,-0.0347084,-0.014946786,0.032037903,-0.06165018,0.025005272,-4.151626e-08,-0.024516707,-0.05623784,0.05095842,-0.04817263,0.057437684,0.04192593,0.047905236,-0.020577716,-0.034521066,0.037115183,-0.0007639534,0.1203787,-0.009200035,-0.07506569,0.051803242,-0.011095606,-0.017960554,0.01612864,-0.02105857,0.009025334,0.01159955,-0.0054880693,-0.1416275,0.04148665,0.03143259,-0.103552535,-0.0012658393,-0.0039907377,0.055543754,-0.02864943,-0.010603305,-0.012677264,0.021800555,-0.048057575,-0.12692702,-0.055922635,-0.026856016,-0.050944027,-0.0437237,0.026119681,-0.05601905,-0.00031168803,-0.015267451,-0.053782456,-0.017869426,0.06485781,0.05872674,0.0032581245,-0.0009756803,0.02644607,-0.015547082,-0.04346436,-0.003786328,-0.04358416,-0.13226181,0.03357625,-0.015288357,0.009486261,0.003738572,-0.005735719,-0.041414514,0.012160845,0.08790889,-0.013983922 +1.14.13.40,"A flavoprotein (FAD). The non-aromatic product is unstable and releases CO2 and NH3, forming 1,4-cyclohexanedione.",384,1.0,-0.06603184,-0.07403475,-0.099036,0.00019622351,0.087940335,0.008794899,0.039412335,0.06664745,0.07527682,-0.056580946,0.017812142,0.015700968,-0.08063924,-0.03733917,-0.09494515,0.020509759,-0.019325746,-0.042850498,-0.062139414,-0.002088749,-0.022098972,0.012559952,0.039654635,0.0045613768,0.0060362113,-0.010480494,0.0055439053,-0.05660589,0.025317905,0.0011359883,0.113221675,0.07029618,-0.012099948,0.0035271524,-0.01435267,0.041465692,0.04197255,0.010567138,0.013417312,0.034281403,0.03795013,-0.017723223,0.045566157,-0.021543281,0.093020156,0.04098027,-0.031389605,0.04737526,-0.03321477,-0.008000122,-0.0014900984,-0.03418042,-0.13920707,0.047408473,-0.0028149714,0.037276756,-0.04895393,-0.033715647,-0.04089089,0.034155816,0.0141107775,-0.039877355,0.033351533,0.016913613,0.05047109,-0.05749258,-0.05728347,-0.028411904,0.052893117,0.0017251844,-0.0053842757,-0.018912172,-0.1050428,0.021505048,0.023097148,0.047750987,-0.076676965,-0.06344045,0.06926788,-0.011247324,0.09949351,0.010983344,0.10545435,0.0737327,0.08293273,-0.016425528,0.027441552,-0.031012274,-0.053084195,0.061323564,-0.06929156,0.040340226,0.033616275,0.029776268,-0.08172156,0.06715968,0.11367461,-0.051281687,-0.054121237,0.040497396,-0.03590793,0.013001756,0.020835973,-0.031014772,-0.104039446,-0.07961315,0.004048552,0.055150308,-0.015064337,-0.024234634,-0.035548974,-0.003600846,0.014485189,-0.13551791,-0.009839073,0.007945833,-0.0049145794,-0.04414141,0.019973086,-0.016256575,-0.03706587,0.09138421,0.031092476,0.07950591,0.006400652,0.0009594054,-0.050943244,3.6061873e-34,0.042653155,-0.0051578097,-0.0023263926,0.028087107,-0.008777409,-0.018024428,-0.07987432,-0.060598306,0.027404618,-0.026082456,-0.014852868,-0.0014817717,-0.011281275,-0.04527206,0.056087326,-0.005949784,-0.03773368,0.00542427,0.112163,-0.14411545,0.013008062,0.0659871,-0.015456123,0.059003454,-0.0048145787,-0.04504027,-0.06085462,0.03337752,0.0026054184,0.03176425,-0.011407608,-0.009749524,-0.05419776,-0.031600386,-0.046843592,0.025494855,-0.12834905,-0.11118399,-0.072841264,0.058565814,-0.02076347,-0.046208266,-0.011594268,0.008182812,0.011909142,-0.044197433,-0.083721936,0.09685098,-0.032826673,0.068336226,-0.0014799606,-0.016522141,0.10634265,0.103452146,-0.10885704,-0.018895013,-0.015048304,-0.024280276,-0.0028025657,-0.011991168,0.0023387088,0.07914249,-0.064825594,0.07229731,-0.08801192,-0.028005553,-0.042665463,-0.04619527,0.022713935,0.106217064,0.0626443,-0.0054508187,0.10704557,-0.004996334,0.10084598,-0.049875706,-0.04596632,-0.033026133,-0.009157509,0.061217327,-0.016141849,-0.038285665,-0.0155204125,-0.012411211,-0.0549961,0.019074997,-0.03936307,-0.03476965,0.01405513,0.033738483,-5.5390155e-05,-0.06315715,0.02442811,0.030310098,0.030337902,-3.5337052e-34,0.019319406,-0.085479856,-0.005341843,0.02144818,0.050121266,0.011337369,0.004381671,-0.03518723,0.017293898,-0.050521523,0.05398849,-0.09649046,-0.0063252365,0.041043136,0.03209518,0.013431092,-0.044496965,0.026643379,0.09861013,0.054355055,-0.018835269,-0.034043994,0.013982683,0.13625728,0.033293154,0.0018746529,0.011626449,-0.057907775,0.004953583,0.05004881,-0.04361648,0.0016589273,-0.047906585,-0.009540618,-0.0832937,0.023358395,0.013724582,-0.025821328,-0.057739742,0.0023929987,-0.02002327,0.019034475,0.039110996,0.0687115,0.08016002,0.048552442,-0.028076772,0.06037312,0.09018128,-0.016856965,0.009850884,0.04264471,-0.0024918583,0.046763763,0.055347137,0.08648786,0.038912967,0.06631604,0.014886269,0.018671652,0.015470156,-0.11709437,-0.009477482,-0.01156988,0.11103979,0.03754467,2.4685316e-06,0.11546498,-0.009741825,0.03564226,0.1216434,0.028773503,0.01466962,0.018911883,0.039558318,-0.057084177,0.013677171,0.035428222,-0.016532429,-0.0065465756,0.0008810216,0.0070518567,0.018166997,0.030133214,-0.09045784,-0.1423543,0.009190794,0.02353395,-0.02896793,0.022864249,-0.0040478595,0.08014969,-0.011091037,-0.01246079,0.053129375,-2.7597919e-08,0.013972507,-0.07018177,0.007734767,-0.035847154,0.08555233,0.03282279,-0.0063141696,-0.046351787,0.004876546,-0.051503498,-0.03848822,0.11004743,-0.012632339,-0.012042616,0.057552908,-0.04046811,-0.047393706,0.026872648,-0.023317866,-0.090162545,-0.069917955,0.05945788,-0.041645613,-0.034175977,-0.07260648,-0.031343378,0.0443179,0.021219686,0.03299237,-0.010536413,0.024075449,0.04263135,0.037111323,-0.038295474,-0.11808849,0.05366181,0.016864318,-0.04020276,-0.04938286,0.032155186,-0.08777831,0.032822784,-0.016910283,-0.026708642,0.031496134,0.004335239,0.04169111,0.002242742,-0.031428106,-0.026301682,0.0020838433,-0.02775562,0.03091653,0.013273779,-0.028072694,-0.03334126,-0.010113467,-0.04337405,0.0055938084,-0.09974974,-0.003607354,0.048465654,0.11544284,0.04853485 +1.14.13.41,"A P-450 (heme-thiolate) protein. This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase and EC 2.4.1.85, cyanohydrin beta-glucosyltransferase. Some 2-(4-hydroxyphenyl)-1-nitroethane is formed as a side product.",384,0.99999994,-0.115542665,0.004114908,-0.065656565,0.00426206,0.08633474,0.036422722,-0.09083716,0.05550837,0.015995048,-0.06378175,0.07007798,-0.023075951,-0.12841897,-0.028621739,-0.056893967,0.0066080834,-0.014078319,0.045091324,-0.0145473415,-0.12313923,0.023835296,0.07801607,0.029334914,0.009483381,0.011374505,0.013899766,0.023838257,0.058574423,-0.022274794,-0.025009314,-0.0007643344,-0.031555824,-0.011930329,-0.0237822,0.0231369,0.09261402,-0.030113772,-0.048895575,0.06936976,-0.0767031,0.12314273,-0.120129734,-0.029738545,-0.008842758,-0.009345966,-0.014544722,-0.011099177,0.09109266,-0.0009491671,-0.0184212,0.024554621,-0.04920364,-0.053157497,-0.022095224,0.017097663,-0.06259971,-0.052151926,-0.025361503,0.011008206,0.02528946,-0.012306193,0.054142337,-0.08356758,0.034008723,-0.018181631,-0.05853067,0.014122003,-0.077412225,0.009113823,-0.06947793,0.0010271096,-0.104244344,-0.0005624911,0.029497072,-0.07260425,0.10896624,-0.011713168,-0.0063354145,0.02994662,-0.03850069,0.092780225,0.07555205,0.098124735,0.070819885,0.0046483735,-0.056548595,-0.047134448,0.09485012,-0.051049158,-0.0629857,0.06286914,0.025792424,-0.0383918,0.04055144,-0.04276365,0.08610766,0.050046314,-0.0040627006,0.010242214,-0.013621504,-0.01555497,0.02411979,0.035590623,-0.06621913,-0.02886442,0.035827383,-0.0585046,0.074338414,0.11425528,-0.024557257,-0.017275289,-0.023426656,-0.023404954,-0.0023228903,-0.0010862796,0.052044656,-0.045247197,0.00041095127,-0.0913837,-0.04773811,-0.02793308,-0.014078002,0.024261989,0.09008272,-0.08362919,0.021514105,-0.05803029,4.1565693e-33,0.07280948,-0.0142581845,0.0141894845,-0.018661082,-0.013346965,-0.04155612,-0.053311035,0.04587406,-0.019700347,-0.027907023,-0.04819438,-0.11857418,0.008028976,0.009664882,-0.041946378,-0.016161485,-0.08637816,0.018733291,0.11083173,-0.010769521,-0.084242225,0.042001925,-0.053742,0.029544542,0.045424752,0.06007813,0.0026734658,-0.050643217,0.063106276,-0.021578949,0.009645749,-0.088650584,-0.017136661,-0.082771905,0.022270067,0.008596577,-0.019248463,-0.036994487,-0.05830222,0.0422093,-0.06261133,0.0014160047,-0.008301005,-0.08280754,0.012030163,0.0017167925,-0.06410609,0.061310943,-0.018790178,0.044614792,0.065762,-0.02861917,0.09510643,0.07606551,-0.056485068,0.030229459,-0.0033957963,0.0433607,0.032698873,0.031228036,0.06683926,0.07442179,0.003873049,-0.003953923,-0.014042267,-0.006024144,-0.047152232,-0.02976189,-0.014626846,0.09944758,-0.022201682,-0.0037492323,0.044767387,-0.013702594,0.026976349,-0.009076268,0.0034151361,0.06437669,0.033308133,0.022466674,0.004262687,0.039483607,-0.006182649,-0.033735678,-0.023129582,0.030689985,-0.047735974,-0.028390609,-0.004414998,0.019949451,0.0444662,-0.052450288,-0.035435233,0.046176787,-0.016367063,-4.7448065e-33,0.05722566,-0.08778359,0.0070458357,-0.06470668,-0.03504999,0.04430596,0.03474039,-0.03766153,-0.049266677,0.05032142,0.119859606,-0.007682254,0.03619685,-0.04953599,0.02086205,-0.013616317,-0.051540572,0.10917829,0.005375748,0.07830929,0.036680527,0.054683432,0.01884562,0.0011391048,0.03155265,0.027578905,-0.0021253708,-0.010803137,0.040307853,0.036704317,-0.018790692,0.011263471,-0.087740235,-0.061928973,0.01742126,0.046406124,0.00075568055,0.007714318,0.014052834,0.031575266,-0.03847657,0.08099421,0.014536277,0.09488973,0.072496675,0.07777605,-0.036262956,0.0037374252,-0.050302185,-0.005846695,0.029987868,0.076466106,-0.043199163,0.057474386,-0.0034893735,0.004850386,0.06721663,0.009003513,-0.045476407,-0.061243463,-0.098885566,-0.044349883,0.01925992,0.0049992264,0.04880282,0.08242066,-0.017851815,0.04553402,0.04569277,-0.006562358,0.06373738,-0.032453105,0.027534045,0.043214448,-0.011300463,-0.01456227,0.06284623,-0.030738652,-0.006627836,-0.0026932152,0.005099223,0.00516255,0.007176974,-0.034092873,-0.03677925,-0.09222579,0.05357021,0.1731573,0.04327643,0.04175135,0.007178754,0.05773574,-0.052239314,0.07263996,0.043826822,-4.6548955e-08,-0.07249838,-0.08914961,0.06253224,-0.054842193,0.007968129,0.032524705,0.10259224,0.011966318,0.044968814,-0.015189978,0.03744802,0.056603555,-0.07037108,-0.031291038,-0.023021795,-0.02975758,-0.04751486,0.05158632,0.030605488,-0.020649472,-0.05309434,-0.008754383,-0.05198158,-0.0062563256,-0.009357133,-0.1171457,0.01564968,0.022564856,0.026871484,0.007331726,0.00868879,0.056824863,-0.05666421,-0.059156574,0.019061295,0.027911248,-0.04161865,0.021842128,0.0049909162,-0.011050089,-0.12395821,-0.05625272,-0.0050136107,-0.014333457,0.04355941,-0.0243188,0.026995394,0.05151499,-0.010685958,0.03093684,-0.036135364,-0.05563401,0.020826697,-0.11022593,-0.108041964,-0.028953874,0.032814875,-0.045495007,-0.019782962,-0.08171537,-0.0027902743,-0.013506214,0.17057644,0.021412145 +1.14.13.42,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.14.13.43,The enzyme cleaves the anthraquinone ring of questin to form a benzophenone. Involved in the biosynthesis of the seco-anthraquinone (+)-geodin.,384,0.99999994,-0.090287745,-0.002115014,-0.09722607,-0.035299264,0.00023571787,0.0039666784,0.029751979,0.019841837,0.08818885,-0.05831129,-0.02585729,-0.013248081,-0.04247287,0.024742005,-0.11290083,-0.0049685435,-0.096263126,0.02727737,-0.065976426,-0.059028205,-0.047995534,0.0035921051,0.026950061,0.075149685,0.022808293,-0.052453347,0.042816557,-0.0012847661,-0.05755392,0.082470454,0.022186916,-0.0023593255,-0.049596146,-0.0288847,0.0024523435,0.06329085,-0.011171753,0.013966634,0.09622836,0.086182244,0.0355076,-0.03718561,-0.039391432,-0.043651115,0.026152542,0.0075181243,-0.037503354,0.03703093,0.07350962,0.006230713,-0.054796036,-0.0076765316,-0.07890753,0.059358686,-0.05212916,0.0002652671,-0.052294444,-0.02349408,-0.01564465,0.031882703,0.0153129585,-0.03762609,-0.009058981,0.11176916,-0.033382725,-0.03183711,0.050647765,0.0025715216,0.01684224,-0.008981926,-0.028547306,-0.032557417,-0.06895778,-0.039745547,-0.034271836,0.07541228,-0.05623994,-0.007956519,0.011861694,-0.07215695,0.045266017,0.039461236,0.072911784,0.16852425,0.039532512,0.03484293,0.06285486,0.047419947,0.08865683,0.034142945,0.04897763,0.0029635685,-0.072472475,0.0070186295,-0.06419846,0.009169492,0.062546976,0.01268942,-0.032402918,0.009659231,-0.01929537,0.02503807,-0.07174964,-0.11393266,-0.036749773,0.032933712,-0.010532712,0.056458607,0.022076461,-0.067606814,-0.042363238,0.028701117,0.07469351,-0.015350081,-0.010816793,0.10547785,0.015097189,0.015732082,-0.039318696,0.07395457,-0.021892913,0.040178515,-0.06520296,0.04461567,-0.049319584,0.033041693,-0.06286263,9.08492e-34,0.07240343,0.0692607,0.07120292,-0.057768647,-0.016601676,0.047078345,-0.15246028,0.03928103,-0.113146886,-0.016759535,-0.019828208,-0.09825728,0.005188922,-0.033300336,0.013957991,0.019436296,0.0057485015,-0.025063932,-0.026868748,-0.047107283,0.022449022,0.050887946,-0.047746714,0.0293717,0.035349876,0.10331961,-0.027503856,0.08097606,-0.07546693,0.023647904,-0.046394136,-0.043705903,-0.06035273,0.02597349,0.01429135,-0.012979508,-0.014270886,-0.04265335,-0.023205517,0.030448241,0.017068654,0.036196467,0.021064924,-0.004040214,0.023348112,-0.081121944,-0.09687549,0.08321403,0.06824865,0.054333147,-0.017942082,0.0017180375,0.0880696,-0.020424789,-0.0633574,-0.008126324,-0.04303433,0.01665579,0.02462253,0.032159578,0.02367419,0.0031760433,-0.04766412,0.050737616,-0.021395935,0.037539195,-0.06912521,-0.007291023,-0.058691606,0.053169817,-0.029609004,0.0421857,-0.02263912,0.10715346,0.07059071,-0.05327934,-0.010072811,-0.027669622,0.026389416,0.03179432,-0.0955707,-0.101957664,-0.024211824,0.06505748,-0.056901906,0.026946157,0.056895107,0.00553805,0.03964011,0.016722767,0.0067129955,-0.06193983,-0.07753565,-0.033029955,-0.00972594,-2.4808707e-33,0.07158807,-0.056053437,-0.0037337022,-0.09330745,-0.049343884,0.058911484,-0.081516534,-0.07570008,0.0017097897,0.021636538,0.029062022,-0.021018721,0.039747164,-0.022694513,-0.00451747,-0.03728775,0.040342297,0.029668031,0.057218365,0.007884334,0.005593782,0.028599884,-0.059692208,-0.040874075,0.022363026,-0.019181633,-0.0052458663,0.07078075,0.03075587,0.09729543,-0.08642406,-0.017775586,-0.097309396,-0.044073954,0.03633483,0.122701414,0.033775233,0.036449417,0.046588276,-0.0030266955,-0.0005077205,-0.05492875,-0.012500442,0.10929103,0.115133524,0.0739077,-0.06852365,0.04728344,-0.028641192,-0.03328159,0.020346802,0.022470206,0.04610446,-0.003623819,0.028387478,0.028497398,-0.032152932,-0.082680576,-0.022958502,-0.083168305,0.01609962,-0.013209795,0.0052947677,-0.0043594213,-0.002665781,0.04886531,-0.033524428,0.06812637,0.016087495,-0.075956866,0.10668392,-0.033613347,0.042132195,0.06061214,-0.081844464,-0.03178546,-0.0255437,-0.03729303,-0.0007247661,0.017368086,0.034086082,0.011192672,0.038864214,-0.022253454,-0.039847996,0.008959634,0.02789327,0.105763644,-0.041946355,-0.008843619,-0.013706615,0.048907496,-0.018044716,0.06038517,0.027618218,-2.9877732e-08,0.08372619,-0.039699603,0.03044263,-0.07656444,-0.036908243,-0.025411323,0.0612088,-0.004528005,-0.03655031,-0.04286979,0.007777533,0.08280059,0.020671694,0.047518905,-0.045177005,0.029241493,-0.018387519,0.008095145,-0.00702312,-0.0061632562,-0.02423947,-0.012791395,-0.05910668,-0.018569814,-0.021759031,-0.05763573,0.048215922,0.010186084,-0.031297278,-0.06710613,0.04226069,-0.033073604,0.032028247,0.008728373,-0.088343516,0.095211335,-0.13189228,-0.014752872,0.07781005,-0.072292656,-0.004218665,-0.05080361,-0.028951187,0.010850784,0.048820537,-0.022496024,0.06816339,-0.021432804,0.047480993,-0.0077398336,0.05396597,-0.008129037,0.06467769,-0.07962385,-0.057490896,0.029306227,0.049886752,-0.024518479,0.024754258,-0.07619671,-0.071714826,0.0012099992,0.123757236,-0.042611077 +1.14.13.44,"Also converts 2,2'-dihydroxybiphenyl into 2,2',3-trihydroxy-biphenyl.",384,1.0,0.046057884,-0.041411392,-0.008540734,-0.06566178,-0.012458621,-0.046487797,-0.0320249,0.021997679,0.03194291,-0.055324685,0.040345218,-0.06230401,-0.012163587,-0.042865377,0.013377306,0.087579526,-0.092051536,0.09510161,-0.022231406,0.010622839,0.062478982,-0.0074895234,0.022715595,0.034593184,0.036537673,0.035952847,0.013321895,0.02225125,0.008731221,-0.059173763,0.09184015,0.058131862,-0.08193037,-0.04492848,0.040646862,-0.01994214,-0.016283477,0.027236095,0.058448456,0.03344899,0.042511765,-0.06200577,0.019028723,0.02393077,-0.054158542,0.0141350245,-0.06272231,0.06762237,0.03177713,-0.012696363,-0.07445467,0.0017292689,-0.055325978,0.074150145,0.029801644,0.08001178,-0.021461554,0.08171438,-0.030766195,0.024292702,0.0028822597,-0.019363064,-0.018820873,0.029696414,-0.038550835,-0.04569045,-0.021364236,-0.095716245,-0.022569241,-0.0075526033,-0.053668335,-0.06419909,-0.025791114,-0.054394573,0.0154829705,0.0057434677,-0.029267235,-0.020356992,0.039010644,-0.08375304,-0.021235842,-0.012026008,0.061346024,0.072226,0.027182844,-0.0073740184,-0.036786854,-0.043603867,-0.038400494,0.011795145,-0.052152306,-0.013161398,0.040441316,0.022338066,-0.045615148,0.061404943,0.046926394,0.023234332,0.056832284,0.04791921,0.011057732,0.044222925,-0.014274669,-0.13035129,-0.10438049,-0.04169765,0.034759,0.04309388,0.015912712,-0.015406582,0.032598734,0.0082407035,0.04319341,-0.03969999,-0.08713353,0.11132115,0.010063008,-0.03757748,0.067924194,-0.018750245,0.013373622,-0.00701358,0.008409766,0.059874065,-0.116902426,0.06941813,-0.027610373,4.0022108e-33,-0.006780514,0.1124682,0.02990566,0.08916181,-0.048648715,0.034194358,-0.12787934,-0.042091142,-0.04366712,-0.07413025,-0.042827792,-0.046476338,0.057010464,0.052520063,-0.017616283,-0.1034886,-0.010275304,0.037866615,0.11429613,-0.014456367,0.031203948,0.09283137,-0.08504761,0.057487246,0.019623235,-0.04415608,0.048623346,0.008718163,0.07055846,-0.002606308,0.03328247,-0.026761282,-0.01843353,-0.009475626,-0.030610653,-0.050429314,-0.06208155,-0.036619738,-0.015986063,0.024304502,0.057181332,-0.024423847,0.05778476,-0.04945887,0.06536983,-0.015813407,-0.0062321452,0.042856455,0.014100356,-0.004828883,0.053124532,0.030254925,0.07884666,0.053312182,-0.046888262,-0.019722322,0.03947132,-0.011737758,0.062327556,0.04443416,-0.024088088,0.11651351,0.022705194,-0.024819288,-0.004432573,-0.048935033,0.009178583,-0.067039385,-0.06078912,0.005796206,-0.0666917,0.021826433,0.10157257,0.062749214,0.058385827,-0.050833598,-0.043487657,-0.076315746,0.09790299,-0.0097401645,-0.06573669,0.0070218225,0.0805171,-0.052784536,-0.06853999,-0.056658953,-0.04736033,-0.11668569,-0.07298576,0.028779326,0.017425137,-0.038829453,-0.0706388,0.033729814,0.0015956814,-4.2355266e-33,-0.02787446,-0.0285931,-0.03780799,-0.034187555,0.03220894,0.013294885,0.04183333,-0.038814332,0.040650368,-0.023005722,0.16152307,-0.029630115,0.008056853,-0.08025538,0.049338,-0.0047262902,0.0669404,0.023057304,-0.042345025,0.011908557,0.09763765,0.044648863,0.001794742,0.08939174,-0.04046573,0.07439664,0.10763926,-0.0065065715,0.04718506,0.15683845,-0.02460052,-0.051358383,-0.044080526,0.03120384,-0.032196358,0.068693146,-0.027715633,-0.028057951,-0.054879073,-0.006790057,-0.0896138,-0.011481124,0.028878933,0.023516858,0.008494963,0.023615813,0.036861382,0.02209811,-0.044145517,-0.062089905,-0.012342868,0.033275343,-0.07532353,0.025122862,0.016898759,-0.038653165,-0.041011836,-0.045468222,-0.0018758716,-0.061199043,-0.08946956,-0.034601152,0.07188722,-0.045465514,0.0035862466,0.045709673,-0.07244315,0.044213776,0.005635404,-0.0035722596,0.077536054,0.03832475,0.0051044305,0.0751221,-0.040030252,-0.09348146,0.049817305,-0.03711818,-0.04307263,-0.040602725,-0.0069525945,-0.064306356,0.065734625,0.015726821,0.0023161853,-0.14059846,-0.017170535,0.019575112,-0.031543244,-0.0056953104,-0.017234799,0.07569734,-0.071081914,0.03603598,0.06299619,-3.1166632e-08,0.014219844,-0.07147921,0.004769561,-0.023166,0.021782475,0.009888898,0.02313911,0.036134385,-0.007643435,-0.02402153,-0.0110429255,0.04233495,0.02492972,0.013082018,0.07365152,0.024113962,0.010544663,0.042140953,0.00097411044,-0.09801888,-0.0624931,-0.0334507,-0.004981494,-0.038019817,-0.035383414,-0.01511091,-0.0853935,-0.027384117,0.093562104,-0.04140131,0.064330235,0.017364018,-0.055623066,-0.03589435,0.009217247,0.015726555,-0.069364466,-0.0073499545,0.010795191,0.046139125,-0.012433676,0.029229792,-0.048670888,0.073011115,0.03520821,-0.06817654,-0.023292951,0.054352544,0.0016282975,-0.01435496,0.09889302,0.028548833,0.028264543,-0.005684488,-0.07235469,-0.0370599,-0.0593428,0.004420231,0.0039999853,-0.043177273,0.02179026,0.07382128,0.13957976,0.020680847 +1.14.13.47,"High specificity, but NADH can act instead of NADPH, although more slowly. A heme-thiolate protein (P-450).",384,1.0,-0.021514036,-0.05688339,-0.02517269,-0.025636533,-0.0023812342,0.058805574,-0.0020135797,0.10267269,0.04068069,0.043572284,-0.03965826,0.037031453,-0.086903825,0.10229433,0.048343413,-0.0053823604,0.022463467,-0.005547251,-0.009007622,-0.040414914,0.03100102,0.05984089,0.030783437,-0.035129618,0.02834189,-0.007962811,-0.017158095,0.063117504,0.017264046,-0.09055621,-0.10641924,0.02192749,-0.06000608,-0.0060133375,-0.007630741,0.11293076,-0.07815928,-0.009625593,5.2289924e-05,-0.045471877,0.094975375,-0.050113596,-0.10610605,-0.00698849,-0.01723686,-0.018799711,-0.02594831,0.102987625,0.026205264,0.042261608,-0.069052435,-0.03417856,0.0008864999,0.06275056,0.025084697,-0.028578894,-0.0056867395,0.059434194,-0.009589657,-0.097744636,-0.07305202,-0.030654367,-0.012005527,0.011771811,0.08790883,-0.068570584,0.05451722,-0.022816079,-0.029953178,-0.040791556,-0.033422086,0.022828052,0.026227878,0.059447575,0.008279865,0.06567941,-0.07684967,-0.053567335,-0.0012178184,0.03670409,0.041293465,0.09386703,-0.008887793,0.059471715,0.051298235,0.041673508,-0.03179926,0.041600194,-0.10760148,-0.031498156,-0.01299232,-0.036060777,-0.020634757,0.003154751,-0.14763933,0.0058797547,0.060881212,-0.027566927,-0.013463221,-0.03402953,0.005502165,0.082717724,0.016274558,-0.047882292,-0.066770226,0.037208114,-0.055195384,0.051205855,-0.026294697,-0.0072952444,-0.044990562,-0.05002555,0.06701691,-0.05119601,-0.07153283,0.08593911,-0.05927338,0.015694253,-0.09583427,-0.06745871,-0.04103353,-0.009668046,0.021357207,0.016835855,-0.024182625,0.025603753,-0.12054123,-9.630012e-34,0.14727728,0.021811077,0.026206676,0.02983992,0.020313382,0.007943546,-0.091253534,0.061891176,0.022331567,0.013687072,0.005685981,-0.10983713,0.06602404,-0.034102913,0.024295485,0.003661393,-0.0635002,-0.020064764,-0.06967904,-0.009720098,0.015575188,0.09608629,-0.0029720988,0.015902534,0.01068708,-0.024828808,-0.03197698,0.049062833,-0.018239383,0.00089055963,0.0013760495,-0.046057634,-0.045860715,-0.020521266,0.059217073,-0.012616566,-0.057471056,-0.051915895,-0.019418363,0.019658713,-0.023260914,0.016407015,0.0021608477,-0.04760434,0.05154097,-0.12862314,-0.022595217,0.015029771,-0.078008085,0.03840502,0.07117038,-0.06086507,0.13756347,-0.017460775,-0.037987728,0.013811244,-0.015242673,-0.03743283,-0.02440696,0.10532068,0.09020413,-0.009577095,-0.048997696,0.07357301,-0.088802844,0.034193464,-0.13026339,-0.04603745,-0.000369295,0.11691486,0.047728956,0.018350003,0.039303023,-0.039005943,0.0311807,-0.05688162,0.025675967,0.046279855,0.074071094,0.007888332,0.025532162,-0.066297404,-0.08061414,0.016234657,-0.04873785,0.025744237,0.096550256,-0.0350725,-0.02281714,0.0012949533,0.07017919,-0.06121184,0.012147875,-0.08138686,0.011425796,-8.865226e-34,0.08316388,-0.025452638,0.05151954,-0.045702606,0.0127078155,0.111189626,0.07186259,-0.044214785,-0.038968824,-0.0986704,0.07458624,0.030724758,-0.0026105698,-0.02095636,0.025904318,0.0015947294,-0.05771142,-0.016058786,0.040177334,0.034886558,-0.035229973,0.070613384,0.009416696,0.011396878,0.095556654,-0.05361213,-0.08491934,0.037887726,0.05306796,0.059860855,-0.030823747,0.024657106,-0.11273672,-0.02601233,0.002736333,0.026544398,-0.026306096,-0.022391386,-0.0003995401,-0.003454797,-0.0243743,-0.01551895,-0.007700683,0.03503269,0.06784188,0.084939964,-0.07593089,-0.050690416,0.030522227,-0.011262074,0.035427276,0.01855721,-0.036623765,0.041213762,-0.0049380166,0.008947606,-0.06091123,0.024746127,0.0003571088,-0.02214744,-0.012421446,-0.036850568,-0.017839354,0.04991043,0.04633438,0.009868213,-0.04653907,-0.037578978,0.08419292,-0.044448126,0.04926728,0.019966504,0.061816104,0.067662686,0.022048049,-0.08510394,-0.033145435,0.003636582,-0.01660332,-0.022865161,-0.05035638,0.07643403,-0.08030178,-0.04081407,0.0251893,0.07824193,-0.012565866,-0.012478061,-0.013478013,0.038742542,-0.023600345,0.08481967,-0.004248555,0.041405987,0.013672017,-3.0055567e-08,0.061047383,-0.05262311,0.019996814,-0.03739339,-0.01681535,0.02872027,0.058134496,-0.014812795,0.032918204,0.030914562,0.016900858,0.10303946,0.07226465,-0.013328939,0.06924973,-0.017639697,-0.030566774,0.028501252,-0.030464536,-0.03899834,-0.0343702,0.02075756,-0.050084826,0.06127604,0.015353151,-0.03198939,-0.047282405,-0.04641242,0.012302699,-0.08377317,0.02996631,-0.00034038114,0.04966972,-0.028075276,0.0275751,0.057796977,-0.058103047,0.05736232,-0.057677716,0.03379565,0.008730876,-0.074997105,-0.0634866,0.021655153,0.01793441,-0.019294396,0.058776945,-0.038538754,-0.024670228,-0.015207131,0.05176086,0.052232478,-0.014012037,-0.06941805,-0.07396355,0.043516017,0.0064620837,-0.05848374,-0.0021972482,-0.09779403,0.06867078,-0.021545995,0.09299043,-0.014199038 +1.14.13.48,"High specificity, but NADH can act instead of NADPH, but more slowly. A heme-thiolate protein (P-450).",384,1.0,-0.022645518,-0.051064424,-0.023307871,-0.019573474,0.0028237784,0.059290256,-0.006237317,0.11115903,0.046937685,0.042736605,-0.03272879,0.03228696,-0.08878036,0.09849449,0.040461287,-0.0057657585,0.023572385,-0.009853598,-0.016130317,-0.04806158,0.026524274,0.0614444,0.033602223,-0.0302389,0.02798932,-0.009648633,-0.020290654,0.05664241,0.017418189,-0.089442685,-0.10560632,0.025796395,-0.053594355,-0.0053240843,-0.012757239,0.117045045,-0.07270585,-0.003428661,0.0015945763,-0.044707708,0.09256716,-0.0491319,-0.10347087,-0.0019376759,-0.019597331,-0.025168302,-0.023559457,0.10325828,0.029142633,0.03731606,-0.072092265,-0.031808417,-0.0065122233,0.055482425,0.032067988,-0.028998338,-0.009600541,0.056672547,-0.010959582,-0.09944653,-0.07290167,-0.033965304,-0.012647102,0.01269411,0.08954855,-0.06758765,0.059808396,-0.019710485,-0.026628874,-0.030589513,-0.038480364,0.028983707,0.019109873,0.06295939,0.0039082016,0.05639035,-0.07422671,-0.056598432,0.002249247,0.032254003,0.043924525,0.097520165,-0.011149753,0.06591706,0.05129409,0.037488535,-0.022525173,0.045645993,-0.11447203,-0.038185928,-0.0077430294,-0.029506844,-0.026801186,0.0023738358,-0.14823605,0.013002887,0.06202333,-0.032608446,-0.016597766,-0.030270712,0.0028934618,0.0806659,0.018865801,-0.043906588,-0.0673383,0.031451784,-0.05312266,0.054727618,-0.02467902,-0.0010721358,-0.037370533,-0.047528256,0.060235467,-0.050439164,-0.074531876,0.088857025,-0.056573167,0.0190837,-0.08445669,-0.06397774,-0.036814805,-0.0076926993,0.018438606,0.013018744,-0.02104945,0.026322298,-0.115633845,-7.997094e-34,0.14535378,0.021591455,0.023115052,0.036535643,0.013948663,0.007494964,-0.09357061,0.060349163,0.023667753,0.015172815,0.004823697,-0.11239898,0.057520363,-0.031011589,0.021103144,-0.009292184,-0.06935161,-0.017378539,-0.06910523,-0.012321658,0.011392305,0.08889027,0.0028360928,0.018380342,0.01745157,-0.025011294,-0.032112308,0.04788883,-0.020507937,0.0002560631,0.008309934,-0.038259916,-0.042095866,-0.031668432,0.05538009,-0.016525866,-0.05696027,-0.060173377,-0.014106612,0.01989466,-0.02812991,0.017388752,0.000782814,-0.0502732,0.05512277,-0.1281043,-0.02802313,0.017952899,-0.07876667,0.04215951,0.07012633,-0.057020616,0.13234837,-0.017930944,-0.041498538,0.011438823,-0.017602801,-0.034918923,-0.030202243,0.11148887,0.08856584,-0.005726909,-0.05042272,0.07942512,-0.0873623,0.03263698,-0.13222942,-0.04555509,0.0042446433,0.1137893,0.05001038,0.014925555,0.04113097,-0.04862632,0.031274408,-0.058092494,0.028128196,0.045099005,0.069392204,0.0037777773,0.025274714,-0.0665728,-0.08706284,0.017105075,-0.045785572,0.02720184,0.09678281,-0.033019144,-0.021185342,-0.0012010044,0.06250448,-0.059044655,0.012198005,-0.081994906,0.010933795,-9.628076e-34,0.09112633,-0.031502478,0.05879824,-0.037156533,0.020201543,0.11089533,0.067464285,-0.042007722,-0.044112805,-0.09306041,0.07799124,0.034117065,0.0021898265,-0.022291861,0.026594141,0.009958824,-0.05186555,-0.020617925,0.045769624,0.03713158,-0.02499558,0.07773701,0.0064477785,0.010666692,0.09186348,-0.05397948,-0.08736054,0.03487782,0.042631973,0.058131054,-0.035320647,0.021725472,-0.11584218,-0.032151707,-0.0027540033,0.032832313,-0.023568466,-0.023655254,-0.006973146,-0.00179893,-0.02550577,-0.011643506,-0.004501979,0.024131583,0.06408327,0.08402009,-0.07866368,-0.05053017,0.029595412,-0.0055601094,0.038031537,0.018510284,-0.040906638,0.042943384,-0.009697974,0.002482331,-0.06522005,0.023996802,0.0044537666,-0.016040519,-0.016244026,-0.04009658,-0.01677539,0.05455693,0.044890072,0.009172669,-0.045486286,-0.037810136,0.0811074,-0.041313764,0.050827798,0.023193872,0.061747648,0.07040704,0.019481622,-0.085233316,-0.036360882,0.0052172155,-0.016193235,-0.019088427,-0.052429598,0.07314102,-0.08402175,-0.03978041,0.018486971,0.075107135,-0.011950629,-0.012779506,-0.007089288,0.04693145,-0.026073104,0.0780563,-0.0051693697,0.043195494,0.007952601,-2.9885303e-08,0.06421196,-0.062232994,0.020421635,-0.039809354,-0.009873456,0.034059446,0.057028063,-0.0022490537,0.03297157,0.026734114,0.026511446,0.10802726,0.073681206,-0.0070484197,0.07408367,-0.013751609,-0.03439038,0.02273596,-0.028771227,-0.041335974,-0.03738693,0.024037667,-0.04392215,0.053111613,0.016306866,-0.033375062,-0.04044451,-0.04219342,0.012231073,-0.090002716,0.028238509,0.0017821345,0.05029905,-0.030058654,0.032119703,0.06884294,-0.058617454,0.056305595,-0.055006396,0.03537564,0.0006248983,-0.076206736,-0.066072695,0.018162232,0.01759627,-0.026761085,0.053926785,-0.032370433,-0.026751285,-0.017350582,0.050332457,0.04998025,-0.016379772,-0.07013596,-0.075043,0.04711269,0.0023695615,-0.06162282,-0.0022531194,-0.099880844,0.067873575,-0.018605184,0.091051,-0.017019032 +1.14.13.49,"High specificity, but NADH can act instead of NADPH, although more slowly. A heme-thiolate protein (P-450).",384,1.0,-0.021514036,-0.05688339,-0.02517269,-0.025636533,-0.0023812342,0.058805574,-0.0020135797,0.10267269,0.04068069,0.043572284,-0.03965826,0.037031453,-0.086903825,0.10229433,0.048343413,-0.0053823604,0.022463467,-0.005547251,-0.009007622,-0.040414914,0.03100102,0.05984089,0.030783437,-0.035129618,0.02834189,-0.007962811,-0.017158095,0.063117504,0.017264046,-0.09055621,-0.10641924,0.02192749,-0.06000608,-0.0060133375,-0.007630741,0.11293076,-0.07815928,-0.009625593,5.2289924e-05,-0.045471877,0.094975375,-0.050113596,-0.10610605,-0.00698849,-0.01723686,-0.018799711,-0.02594831,0.102987625,0.026205264,0.042261608,-0.069052435,-0.03417856,0.0008864999,0.06275056,0.025084697,-0.028578894,-0.0056867395,0.059434194,-0.009589657,-0.097744636,-0.07305202,-0.030654367,-0.012005527,0.011771811,0.08790883,-0.068570584,0.05451722,-0.022816079,-0.029953178,-0.040791556,-0.033422086,0.022828052,0.026227878,0.059447575,0.008279865,0.06567941,-0.07684967,-0.053567335,-0.0012178184,0.03670409,0.041293465,0.09386703,-0.008887793,0.059471715,0.051298235,0.041673508,-0.03179926,0.041600194,-0.10760148,-0.031498156,-0.01299232,-0.036060777,-0.020634757,0.003154751,-0.14763933,0.0058797547,0.060881212,-0.027566927,-0.013463221,-0.03402953,0.005502165,0.082717724,0.016274558,-0.047882292,-0.066770226,0.037208114,-0.055195384,0.051205855,-0.026294697,-0.0072952444,-0.044990562,-0.05002555,0.06701691,-0.05119601,-0.07153283,0.08593911,-0.05927338,0.015694253,-0.09583427,-0.06745871,-0.04103353,-0.009668046,0.021357207,0.016835855,-0.024182625,0.025603753,-0.12054123,-9.630012e-34,0.14727728,0.021811077,0.026206676,0.02983992,0.020313382,0.007943546,-0.091253534,0.061891176,0.022331567,0.013687072,0.005685981,-0.10983713,0.06602404,-0.034102913,0.024295485,0.003661393,-0.0635002,-0.020064764,-0.06967904,-0.009720098,0.015575188,0.09608629,-0.0029720988,0.015902534,0.01068708,-0.024828808,-0.03197698,0.049062833,-0.018239383,0.00089055963,0.0013760495,-0.046057634,-0.045860715,-0.020521266,0.059217073,-0.012616566,-0.057471056,-0.051915895,-0.019418363,0.019658713,-0.023260914,0.016407015,0.0021608477,-0.04760434,0.05154097,-0.12862314,-0.022595217,0.015029771,-0.078008085,0.03840502,0.07117038,-0.06086507,0.13756347,-0.017460775,-0.037987728,0.013811244,-0.015242673,-0.03743283,-0.02440696,0.10532068,0.09020413,-0.009577095,-0.048997696,0.07357301,-0.088802844,0.034193464,-0.13026339,-0.04603745,-0.000369295,0.11691486,0.047728956,0.018350003,0.039303023,-0.039005943,0.0311807,-0.05688162,0.025675967,0.046279855,0.074071094,0.007888332,0.025532162,-0.066297404,-0.08061414,0.016234657,-0.04873785,0.025744237,0.096550256,-0.0350725,-0.02281714,0.0012949533,0.07017919,-0.06121184,0.012147875,-0.08138686,0.011425796,-8.865226e-34,0.08316388,-0.025452638,0.05151954,-0.045702606,0.0127078155,0.111189626,0.07186259,-0.044214785,-0.038968824,-0.0986704,0.07458624,0.030724758,-0.0026105698,-0.02095636,0.025904318,0.0015947294,-0.05771142,-0.016058786,0.040177334,0.034886558,-0.035229973,0.070613384,0.009416696,0.011396878,0.095556654,-0.05361213,-0.08491934,0.037887726,0.05306796,0.059860855,-0.030823747,0.024657106,-0.11273672,-0.02601233,0.002736333,0.026544398,-0.026306096,-0.022391386,-0.0003995401,-0.003454797,-0.0243743,-0.01551895,-0.007700683,0.03503269,0.06784188,0.084939964,-0.07593089,-0.050690416,0.030522227,-0.011262074,0.035427276,0.01855721,-0.036623765,0.041213762,-0.0049380166,0.008947606,-0.06091123,0.024746127,0.0003571088,-0.02214744,-0.012421446,-0.036850568,-0.017839354,0.04991043,0.04633438,0.009868213,-0.04653907,-0.037578978,0.08419292,-0.044448126,0.04926728,0.019966504,0.061816104,0.067662686,0.022048049,-0.08510394,-0.033145435,0.003636582,-0.01660332,-0.022865161,-0.05035638,0.07643403,-0.08030178,-0.04081407,0.0251893,0.07824193,-0.012565866,-0.012478061,-0.013478013,0.038742542,-0.023600345,0.08481967,-0.004248555,0.041405987,0.013672017,-3.0055567e-08,0.061047383,-0.05262311,0.019996814,-0.03739339,-0.01681535,0.02872027,0.058134496,-0.014812795,0.032918204,0.030914562,0.016900858,0.10303946,0.07226465,-0.013328939,0.06924973,-0.017639697,-0.030566774,0.028501252,-0.030464536,-0.03899834,-0.0343702,0.02075756,-0.050084826,0.06127604,0.015353151,-0.03198939,-0.047282405,-0.04641242,0.012302699,-0.08377317,0.02996631,-0.00034038114,0.04966972,-0.028075276,0.0275751,0.057796977,-0.058103047,0.05736232,-0.057677716,0.03379565,0.008730876,-0.074997105,-0.0634866,0.021655153,0.01793441,-0.019294396,0.058776945,-0.038538754,-0.024670228,-0.015207131,0.05176086,0.052232478,-0.014012037,-0.06941805,-0.07396355,0.043516017,0.0064620837,-0.05848374,-0.0021972482,-0.09779403,0.06867078,-0.021545995,0.09299043,-0.014199038 +1.14.13.50,"A flavoprotein (FAD). The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position [2]. If C-4 carries a halogen substituent, reaction 1 is catalysed; if C-4 is unsubstituted, reaction 2 is catalysed.",384,1.0,-0.05303061,-0.064296596,-0.07362967,-0.006864581,0.11713194,0.05620505,-0.033954274,0.054321636,0.04067475,-0.048274253,0.0029130343,-0.0063443137,-0.10200808,0.015075955,-0.09740712,0.05885328,-0.07180041,0.018232815,-0.076079406,-0.035013,-0.0012031486,-0.07071532,0.03174881,-0.016237639,0.036199987,0.019718442,0.029357396,-0.08461618,0.01690696,-0.029615639,0.08955459,0.05414587,0.039658945,0.039629385,-0.034109443,0.04602347,0.033774573,-0.052884262,-0.0023989084,0.022324797,0.0405508,-0.0024756063,0.014351782,-0.022433495,0.07792744,0.01682135,-0.026925124,0.04795278,-0.034444667,0.0065336735,-0.011730615,-0.049029496,-0.12325259,0.056300268,-0.01493049,0.0844862,-0.04682446,-0.0642226,0.01980745,0.03333791,0.057392158,-0.030680712,0.021222766,0.006578106,0.039396953,-0.07626545,-0.030847684,-0.039040856,0.04957678,-0.007971388,-0.026513591,-0.02348482,-0.10340793,0.030182121,0.059422426,0.040907767,-0.04985934,-0.03395468,0.052135546,-0.017523875,0.08604268,-0.012373959,0.09350837,0.030241864,0.07325295,-0.046144824,-0.002972512,-0.02001435,0.006125711,0.06833383,-0.033619285,0.012401274,0.011388079,0.00088282215,-0.08161798,0.07812677,0.08110978,-0.059463184,0.0063293083,0.0155622065,-0.024660535,-0.016124975,-0.0016930624,-0.021574933,-0.0631746,-0.07656271,-0.041075226,0.071862034,-0.04521079,-0.039006427,0.017490558,-0.03520722,0.034734912,-0.075193435,0.008078107,0.026332643,0.0031493914,-0.06113738,-0.02480508,-0.0069177346,-0.041726045,0.0654362,0.06559641,0.078567505,0.010168339,0.010870092,-0.12949401,6.621663e-33,0.10313179,0.028481318,-0.017172424,-0.00361843,-0.013372412,-0.027353434,-0.048482127,0.01262633,-0.027161324,-0.04062322,-0.05193317,0.019451378,0.01239484,-0.047876094,0.078201376,-0.023219207,0.009888592,0.01575135,0.052623335,-0.10096062,-0.011008212,0.062842324,-0.008085086,0.041808415,0.0471221,-0.015231463,-0.07887122,-0.009872979,0.041357398,0.03488496,-0.047059406,-0.018393748,-0.058633097,0.020176044,0.0019314282,0.06859089,-0.094359845,-0.11825069,-0.082898565,0.053912267,-0.016350385,-0.010522003,-0.026037948,-0.02448222,0.060653564,-0.05243012,-0.0696757,0.06308785,-0.01858348,0.10777461,-0.012156919,-0.0037331867,0.12992054,0.04521398,-0.057192996,0.035451375,-0.033836134,-0.02333647,0.045769677,-0.03033358,0.003732618,0.07511905,-0.06267945,0.070898846,-0.045728758,-0.018888274,-0.036434434,-0.04060845,-0.019554144,0.11777168,0.026440525,-0.0128572155,0.03961375,0.030958505,0.08268367,-0.051254,-0.023196103,-0.044507623,-0.015184621,-0.015088369,-0.04942315,0.034793045,-0.008697215,-0.023381015,-0.042056955,0.023718884,-0.028415576,-0.06586157,0.0088597955,0.021464143,0.0069330744,-0.059313256,0.031881023,0.008263794,0.073156975,-5.562461e-33,0.055031233,-0.12607536,-0.04053918,0.03691562,-0.010401546,0.03483061,0.04061118,-0.095512085,0.020222094,-0.02660154,0.028984323,-0.07341061,0.016253047,0.014430048,0.02959262,0.0123379,-0.02920521,0.006745725,0.037905537,0.046809647,-0.0148093,-0.005866127,0.045891367,0.10839693,0.029196244,0.0012230352,0.01940895,-0.033696618,0.029267393,0.03576228,-0.060460724,0.020511689,-0.025360063,-0.012466449,-0.07526424,0.020890934,-0.018912585,0.03634359,0.0066515,0.057729352,-0.023739986,0.0077102077,0.018662475,0.07026877,0.06732817,0.021544604,0.0041430388,0.06878294,0.09150397,-0.0899433,-0.0087684365,0.03227124,-0.0013779536,0.05507121,0.02575013,0.05821731,0.057446614,0.050285146,-0.028423257,-0.02290051,-0.015405581,-0.13442118,0.056219034,-0.023683738,0.11571046,0.060830705,-0.007950899,0.12315564,-0.018478176,-0.05635629,0.11974468,-0.035545122,0.03425257,0.07727188,0.05012783,-0.046196833,-0.01558526,0.04194569,0.01402603,0.008136629,-0.022661034,0.0027631712,0.02829745,-0.0100625465,-0.10091715,-0.18507516,0.033751033,0.032053858,-0.024658538,0.022609983,-0.0065466715,0.06885276,0.030407138,-0.036930934,0.08255463,-4.402118e-08,0.03380484,-0.031642884,-0.00040020517,-0.012523611,0.08333558,0.047393154,-0.04730885,-0.053426623,0.030648801,-0.058266092,-0.07495753,0.08089721,0.010098137,-0.01372228,0.07659292,0.0032027317,-0.031719096,-0.010932977,-0.051734462,-0.023118796,-0.096567824,0.06938166,-0.09647172,0.0031535034,-0.0639831,-0.011437692,-0.013253364,0.022277592,0.04384394,0.008994189,0.012908081,0.08209045,0.02317981,-0.041930083,-0.09267221,0.025029048,0.05745564,-0.060440462,-0.031462405,0.030912273,-0.050644737,0.017734794,-0.039644785,-0.0088717565,-0.017307993,-6.683695e-05,0.06800912,-0.05102027,-0.041394014,0.016400434,0.009848192,-0.031071821,-0.0025208453,0.0041167154,-0.04875441,-0.011737227,0.0028165188,-0.08787335,-0.026059004,-0.108156525,-0.0033070773,0.049548954,0.13147165,0.026350733 +1.14.13.51,"The product undergoes non-enzymic cleavage and subsequent ring closure to form the lactone 4,5-dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one.",384,1.0,-0.023730254,-0.06734849,-0.061937977,-0.008688674,0.06310028,-0.07063574,-0.02083628,0.046082668,0.045810625,-0.03973793,0.08317289,-0.018770412,-0.13931538,-0.031379312,0.0052851588,0.10903127,-0.1369001,0.07832676,-0.07186845,-0.009570204,0.070945434,0.012920536,0.010764125,0.046811607,0.0050469544,-0.032365978,0.09737525,0.015600556,-0.0053278147,-0.06074839,0.031563766,-0.05948016,-0.026971499,0.01628622,-0.02582928,0.014388355,0.037176415,-0.06008804,0.038984835,-0.007134183,0.060145725,-0.055291854,-0.01689854,-0.0057385843,-0.033106253,-0.055786043,-0.04210244,0.036307488,0.035103135,-0.006433532,-0.08515164,-0.038942445,-0.032005217,0.046318088,-0.04917315,0.028845198,-0.021481045,-0.05705511,-0.0019168324,0.056404423,0.03435248,0.043063093,-0.043393567,0.00942631,-0.008602961,-0.024698958,0.01821984,-0.05968907,0.018664299,0.04164401,-0.008688758,-0.09599347,0.013221886,-0.058626026,-0.03670926,0.12393979,0.017904527,-0.0377911,0.046608247,0.028291421,0.011336574,0.011650688,0.08319805,0.12085695,0.0015961471,-0.025372768,0.07205048,-0.041951284,0.022538314,0.005372795,-0.02939861,0.044221073,-0.08360765,0.035678603,-0.07752933,0.06547501,0.0798219,0.03652943,0.02544468,0.0515541,-0.051043052,-0.027931977,-0.0074942177,-0.13190128,-0.09770634,-0.003628037,-0.0036033608,0.021586051,0.057281557,-0.0559639,-0.0336165,-0.0708066,-0.07947157,0.043559976,-0.0014820208,0.1463337,-0.0008910051,-0.060558584,0.01852579,-0.022829326,0.02782045,0.072585344,0.043265928,0.026341744,-0.10719301,-0.007950581,-0.03136237,-7.830967e-34,0.028651778,0.03016913,0.018350853,0.039335016,-0.05669164,-0.007681587,-0.09915353,-0.074804686,-0.09241588,0.026746793,-0.042138148,-0.06587392,0.042772103,-0.046515107,-0.020574119,-0.07622191,0.021705221,-0.0096954005,0.049750313,0.060865045,-0.021325916,0.14744034,-0.04809025,0.04961492,0.04840722,0.026672868,0.046659667,-0.017953942,0.07026871,0.03404084,0.008766756,-0.035994668,-0.063890874,0.017014181,0.020599853,0.053593215,-0.056414872,-0.011156146,0.032838732,0.07652664,0.099147044,-0.04116064,-0.008728502,0.014881719,0.029173484,-0.028109005,-0.027227938,0.05552559,-0.009057178,0.009020369,-0.002728243,0.020858904,0.05991964,0.041339908,-0.061668046,-0.08203236,-0.0467143,-0.026498105,0.10117649,-0.03320356,-0.019384036,-0.019979933,-0.01223755,0.040418573,-0.0044803987,0.027975243,0.019852336,-0.03918385,0.005836221,0.0028472082,-0.02626329,0.043151177,0.04896502,0.025657188,0.05027612,0.0022930312,-0.016068907,-0.0059845354,-0.019113047,0.10151453,-0.046879176,0.021326423,-0.031364743,-0.021070424,-0.06788737,0.002146565,-0.03702282,0.004452581,-0.008400077,0.009384771,0.07528852,-0.017051445,-0.0067561166,0.0016770089,0.014127332,-3.978075e-34,0.10838175,-0.1362167,0.02506041,-0.024196818,-0.05476994,0.037341718,0.0017477194,0.012814202,0.025141122,0.020073595,0.12228739,-0.06969787,-0.0064137653,-0.053114273,0.06591653,0.09430391,0.00695988,0.06288443,0.03168434,-0.01593128,0.10281565,0.07727409,-0.0532085,0.042438712,0.059851732,0.055324864,0.022509765,-0.01645862,0.06404899,-0.0022504667,0.013868746,-0.051429942,0.028847747,-0.023604149,-0.006278979,0.08285906,0.009964724,0.007407316,-0.011636021,-0.009174079,-0.07367545,0.022144413,0.027693273,0.074008495,0.021161443,0.015616974,-0.012279326,0.00935642,-0.023291817,-0.03130254,0.077055804,-0.037539836,-0.041504994,-0.024429431,0.009093205,0.119178444,0.05239053,-0.028730456,-0.04170244,0.033664506,-0.019725064,-0.058937326,0.09081305,-0.066947915,0.013988183,0.02602014,-0.023503736,-0.015085984,0.03210919,-0.025450239,0.051964946,0.10805381,-0.024240265,0.03364047,-0.025806949,0.039296597,-0.033800162,-0.053849213,-0.058264803,-0.023219956,0.013375189,-0.06107264,0.014245432,-0.0019577444,-0.024180619,-0.10561008,0.085705705,0.07067629,-0.04678643,-0.007210758,-0.022349248,-0.025147907,-0.0908727,0.096885554,0.084774405,-3.4711135e-08,0.040105727,-0.08017058,-0.012884617,-0.021674842,-0.0010533307,0.060699414,-0.00022961531,0.028393256,0.07511422,-0.04545257,0.023320986,0.109012015,-0.011100906,0.011949365,-0.01634492,-0.04738809,-0.0063605625,0.008133412,-0.007270889,-0.0890423,-0.061696842,-0.030112693,-0.03454422,-0.09018219,-0.05169228,-0.031998258,-0.019178487,0.055733394,-0.053189207,-0.11427874,0.054530464,0.051928043,-0.022817353,-0.0023274797,-0.024486018,0.0009594684,-0.078175604,-0.07365397,-0.03969461,0.061980702,0.0076991967,-0.03641646,0.009745411,0.03730513,-0.012562561,-0.074180305,-0.01844614,-0.028082414,-0.039553683,0.018457638,0.019695107,0.023775904,0.016540127,-0.014655329,-0.07570638,0.028018018,0.02661114,0.023175228,-0.06366214,-0.046978313,-0.08720279,-0.021945188,0.12123611,0.006090547 +1.14.13.52,A heme-thiolate protein (P-450). Also acts on biochanin A and other isoflavones with a 4'-methoxy group. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.,384,1.0,-0.06730966,-0.013551106,-0.10143637,0.029743765,0.029867029,0.06782707,-0.02066421,0.0798775,0.047036357,-0.06685136,0.0043377588,0.008562996,-0.10641329,-0.0062772427,-0.04545684,0.02613437,-0.08419506,0.025720237,-0.013445302,-0.0773255,0.0101717785,0.04146272,0.023370694,0.030957235,-0.07796687,-0.0187587,0.044442765,0.09071094,0.0009485485,-0.006869456,-0.045982707,-0.030418562,0.03238179,0.00814127,-0.019942597,0.14747351,-0.09507343,-0.024286574,0.062226128,-0.058633912,0.17932115,-0.10610021,-0.018180195,0.024621509,0.027494173,-0.034085564,-0.02096706,0.02400776,0.04108673,-0.006150436,-0.07789494,8.3176135e-05,-0.035351906,0.044208113,-0.014440056,-0.046182156,0.060992572,0.03563954,0.04261939,-0.06501387,-0.019648986,0.009886125,0.029647982,-0.00026094052,0.0014681193,-0.06273227,-0.025672665,-0.004045064,0.01070678,-0.061834216,0.025353171,-0.025051253,-0.0039061739,0.06951618,-0.0032364088,0.10625549,-0.11541638,0.0022557294,-0.0466476,-0.025743775,0.0931982,0.031854358,0.021729706,0.14191379,-0.0026727424,-0.021129554,-0.052169483,-0.0008129431,-0.04283561,-0.06379843,0.061909586,0.051184695,-0.018620282,0.024886953,-0.06196205,0.037432745,0.04034586,-0.019448776,-0.049628563,0.015585785,-0.02938101,0.021636372,-0.1192107,-0.04777518,-0.02472724,-0.0044440697,-0.03395961,0.025646567,0.09637689,-0.026617834,-0.049149025,-0.07502503,0.022495,-0.06605171,0.008843125,0.051391236,-0.03784138,0.019291425,0.056929547,-0.048861034,-0.030109128,-0.0044232826,0.037222795,0.023741545,-0.047449976,-0.033220008,-0.08863611,2.9874247e-33,0.088247195,0.021257738,-0.009166402,0.037825715,0.034377288,-0.06580326,-0.06729886,-0.06378394,0.03188397,-0.015989222,-0.09889066,-0.0842925,-0.026997626,-0.0004020465,-0.036776416,-0.05962221,-0.07424838,0.025567977,0.052471336,9.378912e-06,-0.039063506,0.029367045,-0.06056051,0.057881996,-0.0052426867,0.079824746,-0.035544764,-0.010785995,0.029839102,0.0071301535,-0.05780172,-0.0069047287,-0.035182152,-0.09122252,-0.0058674,-0.017252196,-0.04568853,-0.048558675,-0.0921358,0.005811911,-0.039038002,-0.03257173,-0.019910928,-0.080738984,0.07280052,-0.003919397,-0.108158715,0.07134136,0.008798625,0.026257217,0.06235615,-0.05340874,0.14524579,0.024561446,-0.07230554,-0.052490063,0.0025357788,0.013469678,0.0454208,0.06249103,0.13804244,0.0013527132,0.0045738746,0.02353571,-0.016021777,0.06841839,-0.040630005,-0.0055144676,0.028935755,0.119605005,-0.021662652,0.036548294,-0.006734783,0.008169422,0.021940866,-0.024823068,-0.030135687,0.042080134,-0.001464283,0.015630623,-0.009387265,-0.034872662,0.0073585324,0.047117583,-0.0472523,0.006285703,-0.0013425215,-0.0027507367,0.03558187,-0.033497814,0.056800738,-0.03356329,-0.02297503,0.023652315,-0.023975147,-3.6999067e-33,0.04250554,-0.024952155,0.015153141,-0.029672014,-0.06033765,0.028366009,-0.06404285,-0.015312369,-0.021413725,0.026915263,0.11040356,-0.07602965,-0.018138193,-0.024880463,-0.006938259,0.08901527,-0.01904718,0.027839597,-0.020338757,0.02521553,-0.06051538,-0.0015575502,-0.017448893,0.113368176,0.07526747,0.032852106,0.033101406,0.013692334,0.04286929,0.03248966,-0.03800891,0.035888813,-0.06967274,0.0022052128,-0.05676131,0.076754674,0.0026705351,0.039126758,0.039189383,0.032465298,0.060331292,0.031077769,0.03257548,0.055991054,0.009617759,0.060485724,-0.009247508,0.003980753,-0.015616777,-0.05997918,0.04701144,0.042327564,0.03333959,0.015955545,-0.009309451,0.02769774,0.01453881,0.01129924,0.005294907,-0.09229694,-0.055722386,-0.06790031,-0.00654529,0.07795466,0.014421952,0.060274545,-0.032787573,0.009657007,0.039254226,-0.010880697,0.08029745,0.015407313,0.0923905,0.082600564,-0.00038978827,0.00054327294,0.03321305,0.0054895533,0.039661724,0.029450916,-0.032197293,7.900395e-05,-0.007252778,-0.09841658,-0.06219314,-0.020970445,-0.011084636,0.11088696,0.009145527,0.026670093,-0.000647347,0.071092375,-0.03139391,0.012494845,0.025096113,-3.8455724e-08,0.047529403,-0.065889634,0.0016050541,-0.026740905,-0.010833326,0.004814887,0.012962849,0.025379416,0.02788904,0.002882572,-0.03702635,0.016173856,-0.0406003,-0.043037485,0.019186072,0.05333654,-0.015807867,0.071606845,0.0051518106,0.002301643,-0.09484713,0.0029010507,-0.0546245,0.013066465,-0.0057719396,-0.09434524,-0.017362189,-0.025903203,0.07175565,-0.009609203,0.042917278,0.028049503,-0.048050117,-0.042024374,-0.028816205,0.10527188,-0.08101988,-0.061090823,-0.013946053,0.01582636,-0.0607756,-0.05979944,-0.071170114,-0.061088208,0.0016408064,-0.00026812375,0.018580554,0.06590607,-0.053522017,-0.053484503,0.011178516,0.008754221,0.044090647,-0.07393121,-0.115906306,0.01337171,0.050408527,0.020001495,-0.009269146,-0.11137458,-0.032247838,0.01479226,0.22142628,-0.005105497 +1.14.13.53,"A heme-thiolate protein (P-450). Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.13.89, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones.",384,0.99999994,-0.039854,-0.0385526,-0.0764349,0.027818438,0.018982256,0.06116483,-0.033989854,0.0953967,0.026440065,-0.086387955,-0.003964527,-0.013937013,-0.107285865,0.0011609027,-0.057597276,0.024808282,-0.083082855,0.011698402,-0.019528933,-0.08123156,0.025287071,0.015572678,0.024947483,0.024852905,-0.049006224,-0.032586914,0.039733205,0.076504625,0.0034324252,-0.024805427,-0.014764661,-0.040083528,0.0477462,0.009322545,-0.011600229,0.12295577,-0.08259884,-0.026720874,0.036926717,-0.045747824,0.17183657,-0.1037095,-0.023385972,0.022612892,0.025653463,-0.04155193,-0.012553807,0.03493963,0.017715318,0.020221379,-0.09370404,-0.02223907,-0.054017954,0.06503581,-0.016372524,-0.057040095,0.0566608,0.05593913,0.01759007,-0.050702486,-0.018873582,-0.011226763,0.01723379,-0.0058231954,-0.0021060714,-0.0548655,-0.009288941,-0.007935148,-0.0006545274,-0.053218067,0.027188804,-0.018450487,-0.042037223,0.06392018,-0.005701397,0.090122476,-0.121119566,-0.009404845,-0.041027814,-0.047558878,0.088729426,0.023256978,0.032948814,0.13362053,-0.0050413203,-0.043489963,-0.09012278,-0.017210042,-0.033208057,-0.051618766,0.047110572,0.06768501,-0.0055278772,0.028596843,-0.033263806,0.060430948,0.052072477,0.005218606,-0.04491412,0.022362553,-0.025980214,-0.0014185224,-0.14989151,-0.060777806,-0.025345882,0.012697325,-0.046650488,0.010198712,0.095323406,-0.01855092,-0.0433895,-0.07485649,0.021842906,-0.054679297,0.007087045,0.055583227,-0.009016021,0.010061784,0.055381738,-0.06830263,-0.047738418,0.008023598,0.08113742,0.01822196,-0.043109406,-0.042890552,-0.08628744,4.9494193e-33,0.08819949,0.02395557,-0.025904804,0.04291078,0.015600353,-0.060311016,-0.051486626,-0.014570872,0.025588656,-0.020799795,-0.11049463,-0.063324936,-0.03215454,0.00073957,-0.017811816,-0.05630339,-0.044986673,0.05233387,0.057761338,0.002017778,-0.035042733,0.036232337,-0.067372724,0.035605673,-0.015634585,0.053785816,-0.044421535,-0.025120303,0.023466833,0.005633332,-0.07374943,-0.014200236,-0.027287425,-0.08027159,-0.000107324115,-0.008581621,-0.05640606,-0.03496753,-0.11106413,0.002586645,-0.034495,-0.014712054,-0.00959161,-0.11054042,0.08096232,-0.0099567175,-0.1094284,0.06144776,0.03343957,0.03424768,0.05695537,-0.042150993,0.14964424,0.02260323,-0.040542632,-0.033370815,0.009573509,0.03427688,0.078534655,0.07274481,0.12509254,0.018799625,0.011754726,0.024743391,-0.040135887,0.075475514,-0.05713497,0.004457893,0.023046995,0.13623774,-0.007683669,0.03349049,-0.0047065085,0.0011578979,0.0425983,-0.04184799,-0.035788376,0.025139665,0.008210694,0.01184521,-0.010876845,-0.029734222,0.00962768,0.020606654,-0.05289089,0.009382552,-0.005205945,0.005776933,0.028429361,-0.01356476,0.041844,-0.031527072,-0.037824027,0.03590645,0.022617161,-5.145626e-33,0.037288625,-0.03506881,0.0024022178,-0.056070767,-0.040574916,0.04447884,-0.040980984,-0.0026764271,-0.008546616,0.04498171,0.12813495,-0.07112407,-0.033431195,-0.029736983,-0.015804715,0.05860821,-0.0118053015,0.033055242,-0.015546995,0.036422443,-0.0733108,0.01386113,-0.028269298,0.1429149,0.072305106,0.011079421,0.055081435,0.036853164,0.045488313,0.046725895,-0.035461865,0.028439673,-0.061441086,0.012106862,-0.048255306,0.083920844,-0.0025969648,0.06251557,0.024883486,0.01649402,0.032956824,0.025135977,0.02723708,0.06826706,0.023126656,0.07773823,-0.011446795,-0.008664427,-0.038262654,-0.04283667,0.032068305,0.040206026,0.011232783,0.04899,-0.007997176,0.038737413,0.002332233,0.018439822,0.005786596,-0.094308674,-0.059738833,-0.071299054,-0.0037437226,0.050364714,0.04297923,0.05658424,-0.066596344,0.018954057,0.031193579,0.018545637,0.08403641,-0.021600112,0.06743525,0.07915026,0.01233042,-0.018517664,0.030919477,0.013520203,0.0111180525,0.031402916,-0.020678302,0.00080520276,-0.0017595615,-0.10277269,-0.0700403,-0.040968575,-0.010340609,0.089630544,-0.011859851,0.04712925,0.00073330087,0.076228335,-0.036199264,-0.0028174482,0.027441867,-4.7607386e-08,0.019919679,-0.07344498,0.02184635,0.0013428611,-0.004120107,-0.022241669,-0.0017016497,0.04625334,0.026179893,-0.0037330508,-0.04376002,0.028030315,-0.020853708,-0.04171783,0.012733944,0.035217736,-0.01652854,0.07304547,0.0004229087,0.022758093,-0.07366708,0.01907012,-0.06725711,0.010386465,-0.02687328,-0.0933733,-0.017861076,-0.022679213,0.07857486,-0.0012493336,0.06026333,0.032126345,-0.02495943,-0.026877997,-0.06386086,0.0850216,-0.04695764,-0.047980625,-0.020322395,0.016777715,-0.04700259,-0.062146027,-0.0778753,-0.059607215,0.03446197,-0.00680185,0.027501559,0.05772811,-0.02417526,-0.04712876,0.0014217534,0.011084314,0.0355675,-0.07131075,-0.08082505,-0.0043985336,0.032349806,0.023797033,-0.01044187,-0.105796784,-0.003055234,0.007442368,0.24728695,-0.002967904 +1.14.13.54,"A single FAD-containing enzyme catalyses three types of monooxygenase (Baeyer-Villiger oxidation) reaction. The oxidative esterification of a number of derivatives of progesterone to produce the corresponding 17alpha-hydroxysteroid 17-acetate ester, such as testosterone acetate, is shown in Reaction (1). The oxidative lactonization of a number of derivatives of androstenedione to produce the 13,17-secoandrosteno-17,13alpha-lactone, such as testololactone, is shown in Reaction (2). The oxidative cleavage of the 17beta-side-chain of 17alpha-hydroxyprogesterone to produce androstenedione and acetate is shown in Reaction (3). Reaction (1) is also catalysed by EC 1.14.99.4 (progesterone monooxygenase), and Reactions (2) and (3) correspond to that catalysed by EC 1.14.99.12 (androst-4-ene-3,17-dione monooxygenase). The possibility that a single enzyme is responsible for the reactions ascribed to EC 1.14.99.4 and EC 1.14.99.12 in other tissues cannot be excluded.",384,0.99999994,-0.04817374,-0.02379904,-0.045350067,-0.043812845,0.10811014,0.070813514,-0.08155091,0.010219444,-0.018775862,0.014300565,0.030188737,-0.045978136,-0.078205995,-0.022963217,0.006525001,0.011242553,-0.059435844,0.043742407,0.025879806,-0.0043827337,0.029339222,-0.07278199,-0.017156567,-0.022865022,0.062189475,-0.027657552,-0.0048258505,0.002082048,-0.09700431,-0.022143615,0.09494148,-0.036129944,0.033428207,-0.055241097,-0.07307717,0.0045453706,-0.022966638,-0.09256569,0.096403785,0.022942271,-0.02495334,-0.010473051,-0.04766247,-0.054215673,-0.0020089042,-0.0647091,0.00993455,0.0066623846,0.0002980483,0.008599186,0.0017248358,-0.09462739,-0.0034502454,0.021645084,0.015122959,-0.076688506,-0.053410515,-0.090130866,-0.031364474,0.07067892,-0.02755892,-0.041481093,-0.057683244,0.024809463,-0.057211388,-0.042343054,0.02184488,-0.045855008,-0.059489347,-0.04668869,-0.0007201093,-0.033490814,-0.03948672,-0.009527914,-0.025634632,0.09132332,-0.01292276,-0.04311729,0.05682545,-0.024251023,-0.024058308,-0.02799876,0.015389208,0.12960723,0.042542927,-0.03312157,0.06420316,-0.00608068,0.021498566,0.13194609,-0.018314619,-0.024884677,-0.029348472,0.0284386,0.031226797,0.0458253,0.041204546,0.01871108,0.0008222372,0.0019574803,-0.057506647,0.067563884,-0.021813981,-0.08256404,-0.07631965,0.08318518,-0.006046464,0.028717674,0.031086836,-0.0077695386,-0.015272623,-0.07164039,0.021228798,0.0058398414,-0.015288139,0.08740259,-0.02624078,-0.02954048,-0.027775107,-0.014288064,0.06863889,-0.014938215,0.1001983,0.072300464,0.010069819,-0.0058463113,0.035516683,5.5865152e-33,0.07968412,0.024024868,-0.0015158264,0.04856978,0.026320333,0.13027084,-0.042158395,0.05293704,-0.048226617,-0.037351657,-0.070819065,-0.025941715,0.028763568,-0.034496833,0.019240359,-0.019394493,0.034942955,-0.05798606,0.06392476,-0.019928597,-0.050391205,0.020066248,-0.06739092,0.0029086675,-0.016618837,8.824289e-05,-0.015057232,0.09926012,0.0031946246,0.010101115,-0.049065292,-0.07402718,-0.07225942,0.0518132,-0.041951567,0.033118807,-0.028238371,-0.040326368,-0.012656012,0.07556831,0.07660686,0.0038800323,-0.024038378,-0.05542921,0.026691424,-0.028005183,-0.023454847,0.1045267,0.14734754,0.054803602,-0.026760405,0.020743623,0.052341104,-0.018831056,-0.0430856,0.14310393,-0.09523808,0.028740337,0.072496295,0.051524043,0.009463472,-0.0111226095,0.11457053,0.019804157,-0.018314715,0.015600125,-0.02817973,-0.0967491,-0.05719694,0.06349015,-0.028499572,0.03020191,0.085951254,-0.0261286,0.08339199,0.019905338,0.0067346566,0.022222422,0.057163585,-0.051939406,0.015567577,0.097194284,-0.019897627,0.0073120566,-0.004776901,0.048933387,-0.08988284,-0.021083977,0.06871306,0.094947405,0.03677646,-0.08617565,-0.04520095,-0.003329677,0.028134178,-5.977851e-33,0.055108283,-0.064982586,-0.040269498,-0.13174361,-0.026577417,0.057105493,0.102577746,0.015289947,-0.017440176,-0.011655199,0.08846345,-0.08238295,-0.01794434,-0.11893866,-0.017115125,0.009144279,0.019266844,0.07341865,-0.031410046,-0.0040233745,0.041604437,0.105399914,-0.024315216,0.040225737,0.038200293,0.028278217,-0.023858521,0.017297566,0.051082943,0.12969914,0.016435983,-0.009067688,-0.030587934,0.015051629,0.011606248,0.10175007,-0.03571102,0.035962157,0.03730899,0.074984446,-0.051553827,0.0075838813,0.047434956,-0.0013091987,0.08402589,0.024845023,-0.10567774,0.021151453,0.034466617,-0.029123131,-0.033159353,-0.035588548,-0.08498058,-0.0139702875,0.006003621,0.058672637,-0.007264308,-0.012225554,0.0510543,-0.068740726,0.024853127,-0.008167768,0.014440352,-0.025785925,-0.034074306,0.023978895,-0.080308706,-0.04288874,0.033791676,0.042350315,0.008025906,-0.055281743,0.0068380665,-0.0062991013,0.08502119,-0.04896221,-0.015858922,-0.06610262,-0.044282854,-0.030897623,0.009370697,0.015966726,-0.04945571,-0.0077210623,-0.110773146,-0.045239117,0.017498607,0.11076927,-0.0040284456,0.030304587,-0.011450866,-0.008006139,-0.046924576,0.049146958,0.06514086,-5.090757e-08,0.027848639,-0.08838093,0.052646484,-0.011029986,-0.044762548,0.010595859,0.004067793,-0.06316883,0.06963721,-0.12838055,-0.015663859,0.1312601,0.02486133,-0.0037126762,0.008481754,-0.04219521,-0.023026073,0.044358894,-0.05236095,-0.0012441011,0.013590928,-0.0019459099,-0.049677785,0.0035890634,-0.02165392,-0.011812158,-0.028754748,0.018788515,-0.020610366,-0.01825535,0.022130914,-0.0038430803,0.018844245,-0.061654076,-0.024434758,0.07195468,0.022355866,-0.0051081814,0.041012317,0.0086979745,-0.011919279,-0.111806,-0.02647705,0.04166786,0.054742754,0.0051801424,-0.01709257,0.023657437,-0.018230367,0.035390068,-0.016346734,-0.003631782,0.014258621,-0.011881656,-0.022383215,-0.008625935,-0.02290536,-0.061907176,-0.05900787,-0.04575837,0.0074098282,-0.021840217,0.16875578,-0.037865885 +1.14.13.55,A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher 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+1.14.13.57,A heme-thiolate protein (P-450),384,0.99999994,-0.053650163,-0.0018133667,-0.011805258,-0.017362334,0.062401645,0.033313647,0.040714364,0.13925777,-0.014294931,-0.008644177,-0.04420238,-0.0031940285,-0.10224694,0.01959218,-0.0077783708,-0.034732558,-0.030254852,0.002917383,-0.01723382,-0.10638138,-0.03445353,0.07247251,0.0025464094,0.022343906,-0.041379634,0.0076441993,0.07824796,0.05872678,-0.0530493,-0.063205,-0.054810204,-0.06102229,0.018607406,-0.010916299,-0.006701109,0.09068713,-0.08347299,-0.08293086,-0.010952347,-0.092118055,0.15394975,-0.066905804,-0.08666313,0.007753829,-0.018699598,0.020761196,-0.026521891,0.08995821,0.019710893,0.04943625,-0.0059959632,-0.057527807,-0.036642194,0.06254974,-0.081450485,-0.00654582,0.010460954,0.06595492,0.028869612,-0.05852234,-0.042052504,0.055210326,-0.00767067,-0.006004378,0.026418068,-0.05879127,0.020978779,-0.0034214258,-0.038941912,-0.019952618,0.01873548,0.002727849,-0.022763569,0.07731248,-0.03922749,0.07330039,-0.04014919,-0.027212577,0.011437841,0.037255052,0.039812796,0.07287245,0.014239338,0.119000465,0.003787386,0.0010865508,-0.048207823,0.06209617,-0.079718105,-0.095041804,0.012594595,0.028682461,-0.029618481,-0.0045388946,-0.09183894,0.065572865,0.015406256,-0.01310128,-0.004300504,-0.011527124,0.021213533,0.030879118,0.0077878223,-0.08889759,-0.052840848,0.017116359,-0.024118342,0.04348225,0.092330635,-0.055845473,-0.0060746805,-0.023153774,0.05866875,-0.057111036,0.006147123,0.07468731,-0.07244431,0.020594843,0.0012799472,-0.06456332,-0.04236184,-0.013196906,0.027481448,0.012866175,-0.07694615,-0.042459883,-0.070271194,-1.969414e-33,0.069288924,-0.027364103,0.033669204,0.038804896,-0.019453434,-0.047025267,-0.0837539,0.047052868,-0.022354417,0.016908946,-0.03602349,-0.13466665,0.034192465,-0.059362005,-0.019689087,-0.090487964,-0.058585085,0.06034531,0.012245467,0.019816976,-0.0836309,0.049936518,0.02003257,0.046817254,0.0463936,0.06585769,-0.007840644,-0.046812277,0.04554968,-0.0013697732,-0.038970187,0.005305826,-0.0054268185,-0.07458524,0.004002881,-0.010975569,-0.0020600092,0.013475234,-0.04436872,0.018992577,0.068640165,-0.0061480324,0.02440536,-0.052235648,0.06460949,-0.050696455,-0.071536206,0.0076884646,-0.025394576,0.018525643,0.053811517,-0.06223775,0.11171514,0.05256895,-0.06312668,-0.012500672,-0.0017847595,0.059505254,0.024816023,0.0409582,0.15333176,0.05112679,-0.037290923,0.03527602,-0.02899574,0.06622714,-0.07563195,-0.023822542,0.031156672,0.10191025,0.007245723,0.027058689,0.066074185,-0.07193837,0.02375425,-0.022167206,-0.012808858,0.08239066,0.041921847,0.013491126,0.039413877,-0.032406043,-0.06082672,0.027892746,-0.035150174,-0.026463158,0.074911095,0.039790884,0.031697445,0.0004766438,0.09494747,-0.07910358,-0.012099614,-0.005689414,-0.046439625,1.684681e-33,0.08856758,-0.080809236,0.030916454,-0.006566846,-0.01791255,0.054239396,0.030501721,-0.015001478,-0.06756518,0.0016390976,0.16975018,-0.028682446,-0.022958463,-0.023083314,0.023704654,0.05660146,-0.05948726,-0.035751607,-0.0111655565,0.05494614,-0.024482353,-0.024103131,0.028627453,0.020678202,0.03421203,0.044634398,-0.0117843505,-0.017428946,0.07293467,0.017265396,-0.025110528,0.03287549,-0.090752445,-0.043683294,-0.06678204,-0.0031115669,0.06454692,0.00039293687,0.020808706,-0.013623617,-0.026707783,0.06182922,0.042629074,0.061500054,0.034875,0.114712186,-0.026352653,-0.06694483,-0.033757817,-0.017499385,0.028698368,-0.0100942785,-0.039738037,0.024526374,-0.06191927,-0.021811059,-0.021197407,0.047239248,-0.067595206,-0.08597172,-0.049211267,-0.0039182273,0.036374416,0.07220863,0.008884541,0.06879439,-0.056472197,0.033216015,0.033595953,-0.011650417,-0.0042717415,-0.006291873,0.08648557,0.04390625,0.062078763,-0.011365845,0.03935091,0.015479253,0.066352114,0.026663966,-0.07130995,0.027870415,-0.11469691,-0.054663483,0.027633578,-0.016371548,-0.04585866,0.092860594,0.03656225,0.04456483,-0.06661761,0.03559,-0.023713488,0.075538695,0.07994894,-2.0345915e-08,-0.0020026295,-0.108536586,-0.0401559,-0.004801912,0.013483606,0.030144196,0.036816478,0.023627633,0.029622674,0.012661056,0.007995285,0.019448655,-0.031845037,-0.024831163,0.011048229,0.0035945983,-0.008010161,0.023886971,0.031240122,-0.02951664,-0.02867345,0.03356777,0.024369169,0.007645173,0.028614309,-0.042629074,-0.05033002,-0.06184881,0.01462905,-0.028784232,-0.0024647883,0.08588759,-0.040516272,-0.027327953,0.11886968,0.05009448,-0.04125877,0.02382293,-0.049426354,0.00033435217,-0.004177614,-0.040717945,-0.0764068,-0.0591324,0.02982482,-0.021911735,0.06253379,0.080434166,-0.06572417,-0.048968274,-0.025582524,0.0036791777,-0.012370513,-0.07538035,-0.12305986,0.011809257,0.034132577,-0.06344272,-0.032187056,-0.07067124,0.0030503646,-0.02750546,0.16146573,-0.004398487 +1.14.13.58,The enzyme from the denitrifying bacterium Pseudomonas KB740 catalyses a flavin-requiring reaction (FAD or FMN). Benzoate is not a substrate.,384,1.0,-0.08676856,-0.056167755,-0.07594702,0.034588624,0.055415444,0.03862901,-0.0060823862,0.09696653,-0.0010581753,-0.017451713,-0.0031052919,-0.08123398,-0.08056754,0.122950286,-0.09814133,-0.018112553,-0.08937621,0.007298693,-0.025922084,0.021291468,0.0019233869,0.072653554,-0.013014231,0.0065743187,-0.013188569,-0.050440386,0.06728202,-0.017464742,0.026116766,-0.023805903,0.04237077,-0.010643306,0.065836996,-0.04981465,0.09067782,0.038233373,0.042323362,-0.041479062,0.07822689,0.015060465,0.0025612407,-0.03383831,0.017656578,-0.07756561,0.05251227,0.041978255,0.053882338,0.033431474,0.014797778,-0.029110847,-0.055202182,-0.014522496,-0.043395136,0.045639936,-0.018132376,0.022718657,-0.014499741,-0.06656481,-0.03561693,0.009763598,0.030067256,-0.00033580183,-0.0154399425,0.012913208,0.018894695,0.006880692,0.0054717152,-0.059949864,0.07572018,0.046113,0.0043372493,-0.05719401,-0.027151791,-0.02462599,0.020029332,-0.0366738,-0.02721673,-0.04060737,0.034226727,-0.042529825,0.06818319,-0.016387722,0.04240437,0.05824332,0.006072338,-0.09760847,-0.010840349,-0.009138573,0.0646756,0.093874335,-0.041703902,0.034801017,-0.008533196,-0.07916959,-0.085181646,0.057307128,0.033488195,0.0499044,0.018369958,0.03303163,-0.035413872,0.04663516,0.006580534,-0.047032766,-0.04918142,-0.058626924,0.028984157,0.07811463,0.016214117,-0.050487906,0.013934277,0.03500098,0.06164595,-0.09308311,-0.02884584,0.0538733,0.054567695,-0.13219817,-0.074708365,0.049893107,0.013255287,-0.046611216,0.013237575,0.07768492,0.016737616,0.002871564,-0.15129972,1.9731046e-33,0.06634682,-0.016651213,0.0014698206,-0.09545371,0.0069000013,-0.06873391,-0.06946613,-0.022871159,0.03601008,-0.0854368,-0.042880155,-0.037512563,0.0062557603,-0.029721208,-0.011175512,0.015365573,-0.026681045,0.012333328,-0.039198957,-0.06241982,0.10494951,0.012040744,-0.034665953,-0.04223939,0.071580656,0.04903625,-0.032888614,0.056248307,-0.03645607,0.015045947,-0.024811054,-0.05504859,-0.08409606,0.019652858,0.008786202,-0.0026408236,-0.10514632,-0.06269143,-0.027824301,0.060696185,0.06970414,0.012812355,-0.031082902,0.01862283,0.08287727,-0.018337972,-0.08980658,0.11734314,0.035684455,0.11483504,0.0920612,-0.015749704,0.020234838,0.02682845,0.002997613,0.04854927,-0.010802741,0.005215147,0.020409096,0.010166487,0.029158961,0.05190735,-0.051832136,0.07755313,0.001855313,-0.010631371,0.021435896,0.033292875,0.029033113,0.011099747,-0.05680201,0.017194012,0.084476694,0.066393904,0.003337348,-0.07221448,-0.004537006,-0.046811663,0.025560481,-0.0026050373,0.010574764,-0.031566866,-0.015224257,-0.052426904,-0.08379561,-0.00014381685,-0.02470754,-0.0393067,-0.030065518,-0.014813256,-0.0004635159,-0.106666155,-0.027711809,-0.005225851,-0.03198576,-2.8580156e-33,0.013559797,-0.016462743,-0.0048429794,-0.004336142,-0.0734136,0.04408837,-0.03322447,-0.016321374,0.029114965,0.0062294737,-0.015120698,-0.04588017,0.024193851,0.0047164983,-0.015257068,0.038783714,0.043848965,-0.03152462,-0.027236504,-0.043206096,-0.035599224,0.043938816,-0.019893358,0.061755005,0.00806793,0.0353755,0.015504067,0.075347096,0.028919451,0.13083343,-0.010078053,0.05408078,-0.060856417,-0.0740569,-0.01132165,0.0074515888,0.04344315,0.014852935,-0.023542535,-0.041335687,0.013938083,-0.012337124,0.0008518144,0.08986283,-0.03476641,0.072666354,-0.05894325,-0.07892351,0.06386054,-0.10774174,0.033399474,0.012018084,-0.0150192175,-0.017356712,-0.03233869,0.040688973,0.060593672,0.019181332,0.021399219,-0.024661474,0.0033280738,-0.12981685,0.03989512,-0.049226046,0.050978493,0.041116934,0.0475634,0.15010013,-0.02320034,-0.03695038,0.059678648,0.05683056,0.09170552,0.06757336,-0.09784004,0.029327491,-0.0032437574,0.0043741013,0.010681755,-0.007836965,0.09249992,-0.012516626,-0.010987351,-0.06743422,-0.018390158,-0.067502886,-0.0007837558,0.05241831,-0.027208189,0.01253144,-0.0042167185,0.011659461,0.04244793,-0.004320098,0.012134077,-2.8704301e-08,0.043629613,-0.07019143,-0.0009487581,-0.016936047,-0.017771304,0.05927059,-0.020945942,-0.02950694,-0.024041507,-0.12087356,-0.06812305,0.04161248,0.01218107,0.060821917,0.03415877,-0.05808623,-0.09329373,0.001682699,-0.09141599,-0.010578902,-0.08043489,0.049275037,-0.07754102,0.0052779163,0.010689364,0.021028427,0.06760016,0.08879039,0.050851393,-0.054702837,0.0062661315,0.08437351,-0.0024408165,0.08424534,-0.12961031,-0.030435303,0.056261156,-0.037021197,-0.13356665,0.013704959,0.001642879,0.005684961,-0.08069317,-0.0012999142,0.00711769,0.01391669,-0.04217829,0.0605502,0.026121587,-0.004424314,0.11615413,-0.01817747,0.00505033,0.023414202,-0.072148845,-0.019424237,0.0022475007,-0.008131477,-0.040494747,0.0016152597,-0.0020738167,0.042401887,0.15137152,0.051404532 +1.14.13.59,"A flavoprotein (FAD). The enzyme from strain EN 222 of Escherichia coli is highly specific for L-lysine; L-ornithine and L-homolysine are, for example, not substrates.",384,1.0,-0.0888771,-0.12028828,-0.08448652,-0.009421732,0.12801552,0.048933797,-0.05841206,0.07468966,0.032522492,-0.043925133,0.021007141,0.024616528,-0.08146971,0.050636187,-0.062219236,0.02139874,-0.067476965,-0.010235982,-0.048370663,-0.028227072,0.038959682,0.038265854,0.010130886,-0.051023237,0.018362844,-0.04946766,0.007018243,-0.06642971,-0.028136084,-0.0051353797,0.069370314,0.031532124,0.04923475,-0.023661628,-0.0014303016,0.035493746,0.048578158,-0.062553965,0.05348571,0.008161494,-0.001444178,-0.014980393,0.034376234,-0.02256808,0.071091555,-0.0052721514,-0.02844991,0.0420475,-0.016030816,0.014506129,0.006752702,-0.04219878,-0.09421969,0.027300732,-0.016438607,0.018530332,-0.0056450036,-0.07929009,0.0033379672,0.037340373,-0.006199342,0.0059138625,0.06932493,0.014637515,0.049646422,-0.07974598,-0.026860936,-0.018438753,0.04944981,-0.025987944,-0.00035925242,-0.047260366,-0.049245976,0.07252779,0.06862949,0.043488152,-0.054925397,0.01023969,0.049194276,-0.0351846,0.07335914,-0.063196264,0.064776585,0.10092796,0.023993809,-0.05546963,-0.0010631713,0.031576086,-0.006206144,0.067325674,-0.02399986,-0.017443826,0.0071543274,-0.011381516,-0.039890155,0.050457586,0.024426524,-0.06942756,-0.058392514,-0.02345141,-0.059349526,0.0015524983,0.039293434,0.04201305,-0.056447666,-0.09335431,-0.0123857735,0.077911444,-0.04065529,-0.09498715,0.023114601,0.0054163593,0.06131488,-0.0832212,-0.003385761,-0.019943966,-0.00506872,-0.07799876,0.0069001717,-0.015975779,-0.03373894,0.06858073,0.043516207,0.12786691,0.029218812,0.05097485,-0.12546481,1.9158512e-33,0.09455482,-0.0025312176,-0.0163593,-0.03483999,-0.008612229,-0.007400328,-0.06356279,0.005950977,0.032854542,-0.046652425,-0.02822603,-0.022985123,0.020692172,-0.025117982,0.05401614,0.035807338,-0.03675646,-0.021109812,0.059985604,-0.07095037,0.014466334,0.034312245,-0.012711164,0.03873496,0.06368833,-0.013669157,-0.048286945,0.016108463,0.007927881,0.028979471,-0.036424156,-0.073013745,-0.03435022,-0.0036288344,0.019139428,0.031390086,-0.07276965,-0.085317,-0.07997199,0.04903243,0.04981327,0.014605504,-0.0118906135,0.0066176723,0.048150744,0.021284537,-0.09164793,0.087929115,-0.056966744,0.08952932,0.042591956,-0.04093789,0.076071694,0.02167022,-0.059511457,0.02040987,-0.033952504,0.014295389,0.016085606,0.0063586575,0.033542637,0.11443479,-0.014003162,0.097593345,-0.05415671,-0.0126109915,0.012873794,-0.07487813,0.008064952,0.14461227,-0.020136343,-0.034765035,0.09087535,0.016836159,0.08019779,-0.060744986,-0.07294365,-0.027626894,-0.0042255237,-0.00031173218,-0.007275088,-0.03598217,-0.03346592,-0.050792687,-0.075492606,-0.0039554867,-0.04099897,-0.04613312,0.022668926,0.003541314,0.024865182,-0.046772458,0.026683148,0.034273952,0.002260487,-1.7711442e-33,0.00022100727,-0.12998378,0.05490917,0.0028179623,-0.02594642,0.025518177,0.03554638,-0.025010198,0.06920732,-0.018323457,0.016390976,-0.06001789,-0.026267784,-0.020636903,0.03698637,0.03892435,-0.084887564,0.007220751,0.05645806,0.0627744,-0.060190648,-0.021365203,0.06373659,0.07271773,0.08204708,0.023223314,0.0022150995,0.018088343,2.057847e-05,0.0051979464,-0.04373572,0.022664107,-0.042295236,-0.054281257,-0.114639,0.04433682,0.019005854,0.017228063,0.017880103,-0.008439655,-0.001783186,0.063504755,-0.0191703,0.0547106,0.0077711246,0.055493206,-0.026259603,0.015173163,0.08646727,-0.0839514,-0.03332404,-0.0034271092,0.035674624,0.019565443,0.022039568,0.036431406,0.036272205,0.08010657,-0.055234212,0.0056481916,0.025178738,-0.11357527,-0.011704661,0.032034267,0.09647754,0.0751637,0.034964636,0.11585686,-0.024596622,-0.015744356,0.12049323,-0.0021317003,0.036903422,0.08250637,0.016213156,-0.042408694,-0.049406767,0.022804227,0.029175496,0.046881456,0.021521753,0.0146726,-0.028740905,0.052153025,-0.042526174,-0.11771335,-0.0068793674,0.11739078,0.04393729,0.02468362,-0.028235137,0.030367374,-0.023886325,-0.053449005,0.08763583,-3.3586474e-08,0.06228291,-0.08075977,-0.023171203,-0.032478612,0.080779396,0.023807824,-0.06944854,-0.033716716,0.020069245,-0.0138013465,-0.06252594,0.13834378,-0.04364057,-0.03621517,0.062392466,-0.032656245,-0.030298978,0.027601136,-0.017773984,0.03361795,-0.03988686,0.062094726,-0.08790364,-0.004177223,-0.04320131,-0.04340458,0.0041465517,-0.0239072,0.054497663,-0.02215829,-0.026348962,0.006258692,-0.009769728,-0.04456826,-0.10550173,0.025747597,0.0035895428,-0.10000343,-0.0060561914,0.06111867,-0.06439769,0.019529663,-0.022569222,-0.036751892,0.013247888,-0.0044536814,0.032481954,-0.0064138807,-0.05483334,-0.031044044,0.00019674834,-0.051419076,0.009851684,-0.00957211,-0.07297067,-0.01583872,-0.029290318,-0.07731985,-0.030340428,-0.08572433,0.01903171,0.06398691,0.1823153,0.018974908 +1.14.13.60,A heme-thiolate protein (P-450). The enzyme from mammalian liver differs from cholesterol 7alpha-monooxygenase (EC 1.14.13.17) in having no activity towards cholesterol.,384,1.0,-0.061821193,-0.04940534,-0.029350184,-0.030588951,-0.009573978,0.01426102,-0.06758573,0.115772985,-0.023383686,-0.0141457375,-0.04175229,-0.01685097,-0.123298444,0.050579548,0.034133866,-0.026058754,-0.039263792,-0.044393834,0.048212327,-0.079770796,-0.023714442,0.03269671,-0.015437935,0.0030219536,-0.035403926,0.023948705,0.09802642,0.037644073,-0.03727366,-0.06430897,-0.05782463,-0.06685775,0.02936217,-0.016762195,-0.023554515,0.057940118,-0.060481865,0.0060789725,-0.039739277,-0.056809176,0.119030066,-0.061078295,-0.050986975,0.0046997974,-0.0339468,-0.024979273,-0.040066715,0.017365629,0.010555685,0.07301861,-0.041947775,-0.037736334,-0.07056226,-0.004891728,-0.026678246,-0.012979478,0.010552437,-0.03471566,0.018448027,-0.06620671,-0.094762184,0.007010462,0.043798406,0.02192941,0.012111633,-0.062759176,0.03151984,-0.028796649,-0.044244282,-0.08505339,-0.015911644,-0.055043697,-0.06606218,0.07027247,-0.051724564,0.048768234,-0.070216954,-0.03493643,0.005871272,-0.020880196,0.04703681,-0.007701575,-0.024393722,0.10570789,0.039768763,0.015037847,-0.067652635,0.062826894,-0.07510248,-0.0650926,0.04039095,0.017135793,-0.00077293837,0.0070726466,-0.05969203,0.026343018,0.009936576,0.034798138,-0.035075516,-0.0025269703,0.04566508,0.036009885,-0.052905984,-0.045662556,-0.056576192,0.021482483,-0.018393317,0.010262474,0.064513594,-0.049149416,-0.028598687,-0.040965833,0.067391425,-0.021676125,0.03445737,0.07310017,-0.027921999,-0.018293055,-0.004810157,0.009882525,-0.01200966,0.013869114,0.07184549,0.04025359,-0.021231726,0.0037741445,-0.014700966,7.74691e-34,0.07189638,-0.043800455,0.048149962,0.009497987,-0.014024803,0.00961243,-0.029351141,0.07728688,0.0035229924,-0.006543629,-0.014359266,-0.081027895,0.045617174,-0.020707482,-0.033334006,-0.006963366,-0.029823544,0.05345154,0.012840768,0.0010779285,-0.072126,0.015091973,-0.015923178,0.07390754,0.038364172,0.032264903,-0.037701916,0.043299906,0.0140012745,0.0052419617,-0.08160236,-0.0396546,-0.018984549,-0.02859827,-0.015661683,0.0033689274,-0.048335347,-0.03061193,-0.09609766,0.037337642,0.027064642,-0.044102076,0.007914655,-0.108645186,0.06635126,-0.028986363,-0.092366904,0.014906693,-0.030680744,0.031934526,0.057104256,-0.019786583,0.075284645,0.043268953,0.0013715628,0.002541785,0.029720355,0.11281141,0.0317527,0.02779195,0.17609055,0.087264284,-0.07767211,0.032126874,-0.017286628,0.075377055,-0.057895035,-0.024861239,-0.0685838,0.16355431,0.054800298,0.030072493,0.0019780665,-0.00814361,0.03806189,-0.026483202,-0.018678444,0.11503886,0.0115259085,-0.032661416,0.013574969,-0.0012574069,-0.036982033,-0.04932287,-0.05258137,0.013868275,0.073452085,-0.00684791,0.002581315,-0.013776352,0.09285351,-0.041703034,-0.09120764,0.01931976,0.0039909687,-1.8855475e-33,-0.00044370675,-0.059345696,0.027841773,-0.042446442,-0.03725138,0.07819599,0.0602519,-0.033153012,0.014477037,-0.054166973,0.13346322,-0.023705112,0.0013364513,-0.064671986,0.118755974,0.048125464,-0.06889146,-0.004428648,0.023021758,0.014569258,-0.020275839,0.025722263,-0.02896156,0.1106232,0.04470124,0.014271075,-0.03390772,-0.023249414,0.10647374,0.018535297,-0.06687701,0.036636144,-0.07385705,-0.025789157,-0.0776928,-0.0012321388,-0.030027987,0.009277478,0.009933863,0.018087171,-0.076568596,0.08317458,0.08203131,0.035762146,-0.022941452,0.091519654,-0.039326925,-0.055935897,0.037222773,-0.03602404,0.016263468,0.038788736,0.019834021,0.031469718,-0.0435096,0.03389201,0.014175513,0.04558342,0.049865007,-0.13878815,-0.052015707,-0.026407061,0.0040602093,0.07782422,-0.0168724,0.07338441,-0.065430716,-0.021178242,0.0065941648,-0.034681085,0.003030365,0.003828986,0.042039502,0.078759395,0.03193454,-0.0072849803,0.042228647,0.021088496,0.026264416,-0.023119198,-0.02085255,0.0406332,-0.05419906,-0.049910523,-0.031586975,-0.042896673,-0.08141827,0.05754708,0.09473287,0.03739814,0.0018958515,0.03868527,-0.10950771,0.016956449,0.042161133,-3.4929332e-08,0.0071131424,-0.12352585,0.0034110872,0.017582132,-0.024743903,0.013212955,0.042890497,-0.008468654,0.06220555,0.003471931,0.029353928,0.10020223,-0.02234712,0.010272064,0.034171715,0.045393545,-0.02611449,0.008756657,0.054640632,0.031835783,-0.011603533,-0.007466671,-0.009565712,0.0112261465,-0.00038226557,-0.021710468,-0.07383417,0.00010422648,0.018272923,-0.06189705,-0.003688031,0.037983276,-0.011487682,-0.014621605,0.054211594,0.07252121,0.007445998,-0.0052180905,-0.04295116,0.05868071,0.020244619,-0.0640595,-0.06059824,-0.058366828,0.017307667,-0.013120031,0.027355667,0.071100205,-0.010633684,-0.04943001,-0.07450167,0.03699546,-0.0060453266,-0.070993304,-0.07331637,-0.00087180285,0.025691636,-0.088334955,-0.019800296,-0.08926154,0.09131736,0.025522433,0.23164977,0.036145195 +1.14.13.61,Requires iron. Quinolin-2-ol exists largely as the quinolin-2(1H)-one tautomer.,384,1.0,-0.03154388,-0.010598424,-0.011779408,0.05100401,0.06916724,-0.102130346,0.047911543,0.038963355,0.007521596,-0.017538898,-0.026833568,0.0066802255,-0.107058786,0.003620752,0.030199239,-0.005240936,-0.03314943,-0.04646379,-0.012737122,-0.026399594,0.018500479,-0.065145046,0.061501633,-0.0075291423,-0.0186276,-0.017022368,0.017403863,0.11333097,0.04492813,-0.040504728,-0.040899556,-0.038619675,-0.06797226,-0.007817046,0.010098288,0.054863464,0.032206003,-0.036671195,-0.05468062,-0.003107291,0.0056918054,-0.022612574,-0.0027962858,0.016343392,0.019749932,-0.023780052,0.036858898,0.052706353,0.023695363,0.04877856,-0.0806289,-0.01881802,-0.012825295,0.036287334,0.03750115,0.06477698,-0.04760274,0.04290167,-0.031370945,0.058542553,0.0112534035,-0.05371613,-0.086489014,0.0035897868,0.06021139,0.059362594,0.07888957,-0.065000094,-0.01900959,0.040564716,0.031777557,0.060092453,-0.109320275,0.07559661,-0.03463873,0.05777273,0.031971548,-0.041295264,0.06862972,0.07483377,-0.101331174,0.030261617,0.013446976,0.03715734,0.043845993,0.08051854,-0.009602308,0.0030993072,-0.07943554,0.012090489,0.06022974,-0.018901287,0.021806503,-0.026178284,0.025969587,0.06120045,-0.0128587065,0.04315749,-0.03581321,0.034220036,-0.05747813,-0.007841395,-0.0018751776,-0.0282127,-0.030462027,0.04976345,0.038885333,0.0105291465,-0.03952394,0.053450223,0.028060628,-0.07696976,0.13352208,-0.05460641,-0.03172415,-0.010366327,0.00022401042,-0.010194867,0.015822526,0.01811959,0.06426627,0.03413141,-0.07244168,0.050306506,-0.032918256,-0.021969065,0.023161724,1.3694863e-33,0.020685257,0.12927946,0.07696391,0.054974817,-0.057641476,0.052073214,-0.11080612,0.004645008,-0.057496917,0.02327964,-0.089207,-0.10036382,0.028299384,-0.05804963,0.006978302,-0.03357238,0.07570988,-0.03475243,0.066398494,0.013095054,0.033733457,0.09709885,0.017995136,-0.029727919,-0.041508265,0.0074719246,0.040542312,-0.030947005,-0.031441383,-0.010431182,0.03993677,-0.06873256,-0.036078036,0.024056606,0.00095503055,-0.038611345,-0.04032863,-0.016303472,-0.04529325,0.047736954,0.038856428,0.069652505,0.025438586,0.03688404,0.06190502,-0.124029875,0.055731777,0.04801347,0.00044961687,-0.045898676,0.04925665,0.040635742,-0.0071026105,-0.03778302,-0.03752481,-0.054987457,0.055227056,-0.07863098,0.049932864,0.07663338,-0.00264345,-0.0078613125,0.01878761,0.024195151,0.0032460834,0.050324637,-0.082297474,-0.0452887,-0.014231659,0.07870038,-0.05854894,1.7831406e-05,0.02659615,-0.04770816,0.0009484542,-0.08534395,-0.023356529,-0.11290451,0.12883265,-0.049244687,0.01449535,-0.044626184,0.017709915,0.02383681,-0.07374416,-0.05661184,-0.044852637,-0.009076012,0.09058886,0.0002951621,-0.0011465021,-0.06358969,0.0004399222,-0.08256803,-0.03456711,-1.8557015e-33,0.011389302,-0.048467197,-0.047186602,0.06886818,-0.0154267885,0.12272369,-0.00095046486,-0.09026383,0.02436481,-0.015039345,0.1299622,-0.07078786,0.038735237,-0.023113484,0.05444727,0.05082997,-0.07249084,0.032026626,0.07781775,-0.032925967,-0.057716027,0.06844625,0.0109219365,0.053814873,0.013514243,0.0704405,-0.06104705,-0.03322287,0.050919052,0.14579463,-0.04875089,-0.06587106,-0.016379936,-0.037072808,-0.028102946,0.0284219,0.060319174,0.043006137,-0.052898575,0.0013462332,-0.025821738,0.0045764395,0.07736038,0.103467934,-0.07765793,-0.002844409,-0.01262412,-0.004057713,-0.11459114,0.0201013,0.0050365715,-0.004257734,-0.119574375,0.017677145,0.016830524,0.047923632,-0.09298119,-0.0014824903,-0.00252886,0.04991899,-0.017262837,-0.057517987,0.04935333,-0.022111379,0.09483314,0.009903757,-0.10291973,0.1271188,0.014030756,-0.029754428,0.0134181,0.0619755,0.07752594,-0.05646252,-0.0024562054,0.049711946,0.026945539,-0.008551899,-0.014104925,0.048574105,-0.022414044,-0.007900071,-0.038585044,-0.0019299448,-0.029021706,-0.08724472,0.059627045,0.063300595,-0.014373006,-0.008562095,0.010918884,-0.028992703,0.026850851,0.06892662,0.04745971,-2.8306735e-08,-0.04563349,0.009696838,-0.009695654,0.0037358252,-0.059959125,-0.049724776,0.043809727,-0.026342986,-0.0036219298,0.031126339,0.014449302,0.090371616,-0.0052112998,-0.04961522,0.06759921,0.049721133,-0.033787843,0.03465827,-0.058802627,0.0078023206,-0.045331337,-0.015279128,-0.08190831,-0.044213276,-0.031891722,-0.039308827,-0.04251479,0.0292348,0.012543536,0.04800306,-0.034834012,-0.028470619,-0.0077630645,-0.054399952,-0.08889734,0.014407092,-0.03904966,0.047920577,-0.023553578,-0.07267535,-0.034284584,0.029640462,-0.09797969,0.022514872,0.012938185,-0.07041287,-0.014038503,-0.03695203,-0.082891345,0.015198117,0.06623242,0.034393534,0.08034114,-0.009021705,-0.012171843,0.0124436235,-0.03531433,-0.008748675,-0.031119565,-0.033839256,0.05414953,-0.05806825,0.13265038,-0.024338108 +1.14.13.62,Quinolin-4-ol exists largely as the quinolin-4(1H)-one tautomer.,384,1.0,0.023026321,0.007824812,-0.007530344,-0.06684842,0.03526775,-0.041231927,0.01963644,0.05105146,0.032401294,-0.0111206,0.012360673,0.020261873,-0.062419407,0.019969558,0.008682621,0.045365106,-0.064583585,-0.025392886,-0.034502245,-0.077751815,-0.040298477,-0.072938085,0.07011924,0.02365393,0.02878851,-0.035771288,-0.010121601,0.097395964,0.06576613,-0.058967914,-0.04279107,-0.0012405389,-0.031769417,0.002911215,0.039011978,0.05478784,0.045891352,-0.030678513,0.009796758,0.036447093,0.039401673,0.010297732,0.008420256,0.033645112,-0.0029330999,0.014826249,-0.03474676,0.07713676,0.022206338,-0.011695957,-0.04808045,-0.005611142,-0.029654866,0.05071258,0.044696655,0.060236976,-0.12929554,0.057143345,-0.020187763,0.07291464,0.035294455,-0.031586673,-0.017471252,-0.0069913706,0.048238546,0.12162195,0.061697565,-0.074657544,-0.017273434,0.05130907,0.009292147,0.06812811,-0.06804172,0.08329494,-0.06907051,0.03437146,0.008460802,0.0058455747,0.01625801,0.06794864,-0.02526676,0.06270326,0.0088805845,-0.042945996,0.01650199,0.016438186,0.0037297688,-0.004548381,0.0262879,-0.028156092,0.012901138,-0.04621316,0.01648819,-0.064771906,-0.007056476,0.03846551,-0.01920853,-0.0012117849,0.07323543,0.036501333,0.005821073,-0.008023205,-0.010386804,-0.04422581,-0.012494046,0.08824474,0.07937377,-0.0029935422,-0.08064036,0.050957244,-0.02910066,-0.09251538,0.13672371,-0.033621,-0.026832618,-0.06583567,-0.03557874,-0.011948395,0.019619152,-0.009346986,0.04056546,0.023514565,-0.0035998237,0.038871776,2.7852211e-05,0.029230768,-0.017851727,1.12349875e-33,0.036638774,0.112294756,0.08800588,0.01918582,-0.015201149,0.0559073,-0.02496679,0.069908656,-0.09195457,0.006731886,-0.10735466,-0.08780404,0.012236535,-0.05308381,0.008700211,-5.018872e-06,0.03597618,0.00055739156,0.007300984,-0.0011855708,-0.023810102,0.125397,-0.03700723,0.021243474,-0.0061485763,-0.031278536,0.056814246,-0.025099607,-0.03937791,-0.02356045,-0.029888194,-0.029820252,-0.060973737,-0.0061788885,-0.013165801,-0.04427487,-0.06986269,-0.014281815,-0.016020533,0.05599876,-0.048824053,0.05532573,0.024240434,-0.02854444,0.012537047,-0.07573193,0.024726585,0.0077750226,0.03280444,-0.101072006,0.030374987,0.017746253,-0.012812522,-0.07796153,-0.036582574,-0.0697194,0.035309523,-0.06592318,0.03824463,0.07582576,-0.014758203,-0.007082392,-0.06877095,-0.062864184,0.008582234,0.044942465,-0.044634294,-0.1257719,0.03189916,0.08703957,-0.020015093,-0.018504342,-0.007593839,-0.048080992,0.03503265,-0.07125354,-0.00085597415,-0.10960179,0.069562994,-0.05029151,-0.010299021,-0.031494852,0.031357985,0.034250535,-0.0527672,-0.07772224,0.03519798,-0.061592177,0.07775049,0.03189386,-0.033570524,-0.022627404,0.017319445,-0.07238653,-0.0456017,-6.164718e-34,0.039579637,-0.0076502543,-0.05832876,0.10335988,-0.02840427,0.12524366,0.016945498,0.016868513,0.026441438,-0.03419962,0.121937215,-0.049109615,0.057761792,-0.009588172,0.05348727,0.05858276,-0.049126796,-0.021128815,0.041083984,0.0128478985,-0.015400815,0.0087088635,-0.023643209,0.028134936,0.037121043,0.0615771,-0.014348004,-0.014933196,0.042172678,0.09197633,-0.08263789,-0.10198086,0.0016007696,-0.0076925224,-0.0144551005,0.036340643,0.07017409,0.036871072,-0.062964216,0.0052570696,-0.016766232,-0.013594674,0.081138164,0.044802506,-0.07038965,-0.014614226,-0.025912529,0.04031638,-0.12745553,-0.017835038,0.00010948389,0.05271308,-0.11192068,0.016589016,0.019544527,0.08712853,-0.09912939,-0.04064534,-0.02380834,0.027052304,-0.026505474,-0.09030102,0.057562966,0.0015543286,0.10005207,-0.016811576,-0.11227342,0.047583655,-0.026575662,-0.04010352,-0.016438989,-0.017866889,0.03014465,-0.0025969222,-0.015470571,0.03661349,-0.0023093862,-0.06995907,-0.009966575,0.09518179,-0.0043541025,0.011206593,-0.010835698,-0.026204558,-0.07598439,-0.020241475,0.081558615,0.12839416,0.044716,0.02541241,0.05411158,0.03101887,-0.0011904271,0.08118388,0.05069618,-2.4578698e-08,-0.0019730297,0.043025576,-0.015331209,0.046000343,-0.07327036,-0.077191256,0.06202148,0.0099084005,0.0038553022,0.031517677,0.05211067,0.07407019,-0.05339351,-0.08082071,0.05762294,0.05052461,-0.09693753,-0.019463114,-0.046384666,0.06520553,-0.020952567,0.036627106,-0.12568887,-0.06933251,-0.03563042,-0.008003708,-0.02462199,0.068169124,-0.023011854,0.008728595,0.03612727,0.0045588906,0.03209989,-0.102346815,-0.035331417,0.022755018,-0.06133614,0.07281626,0.0072057773,-0.03192467,0.022540728,-0.039168697,-0.090596706,0.041085664,0.032699183,-0.05991304,0.01679511,-0.0882724,-0.02559144,0.0057671685,0.034607604,0.06788638,0.0543034,0.014538492,0.011217555,-0.028721122,-0.026624799,-0.01319671,-0.06908845,-0.04475963,0.062174916,-0.041780226,0.14754082,0.046452157 +1.14.13.63,3-hydroxyphenylacetate 6-hydroxylase from Flavobacterium sp. is highly specific for 3-hydroxyphenylacetate and uses NADH and NADPH as electron donors with similar efficiency.,384,1.0000001,-0.038846206,-0.08230684,-0.1160698,-0.008195101,0.03775543,0.08549889,-0.01206561,-0.001006748,0.0033427929,-0.038538326,-0.03831376,-0.060254823,-0.089920305,-0.005295346,-0.056398775,0.045491487,-0.044211753,0.0339109,-0.0069549913,0.025568206,0.039254718,-0.05382873,0.11450636,-0.0118877785,0.09359447,0.016325517,0.041416142,-0.012140805,-0.013697333,-0.02478244,0.056952912,0.025164265,-0.04599909,-0.009458518,-0.012300595,0.0755826,-0.06263048,-0.07214972,0.0079786,0.055580784,0.04874423,-0.047969103,0.017214702,-0.04511597,-0.029903917,-0.019354438,-0.0324774,0.07693187,0.06856154,-0.004608837,-0.0050119897,-0.03900799,-0.090027295,0.05499152,0.039135095,0.024657575,0.039976906,0.0011025033,-0.035177317,0.050774097,-0.010154244,-0.028642388,0.047791477,0.026930783,0.008211788,-0.08371883,-0.035894264,-0.046565857,0.020254519,-0.08455108,-0.10769864,-0.038878083,0.03247228,0.037292194,-0.033215042,0.0628712,-0.048803955,-0.004771746,0.04005722,-0.020364508,0.01825565,-0.048039477,-0.016001068,0.16872205,0.03015364,-0.03712449,-0.08390999,0.016606443,0.03676533,0.036252197,-0.013933511,0.051273737,0.02423175,0.028947962,-0.10237116,0.041184384,0.07543938,-0.013470254,-0.010404785,-0.00398144,0.011126254,0.035638686,0.065389864,-0.107560016,-0.08368595,-0.0058660293,-0.07189533,0.1313316,-0.016081631,-0.0030104194,0.018507075,-0.009184863,-0.011025227,-0.08489698,-0.023364365,0.07182326,-0.053029135,-0.05910565,-0.021254903,-0.069833875,-0.02246679,0.021156099,0.110282265,0.033070996,-0.022417458,0.035387035,-0.13154054,4.3675096e-33,0.086852185,0.04580378,-0.015294935,0.029507207,-0.038451254,0.008750514,-0.004774811,-0.010954361,-0.046179153,-0.09400038,-0.03229114,-0.0060554324,0.03961699,-0.0365383,0.04205345,-0.0013824283,-0.09592327,-0.034862373,0.021423358,0.018990945,0.0748034,0.011862874,-0.009684973,0.050229803,0.032722928,-0.02261354,-0.03329735,0.0482448,0.0043706116,-0.0038164838,0.034423564,0.0040234253,-0.06277075,-0.043423954,0.052091658,-0.023528047,-0.08336064,-0.10508289,-0.039404728,0.072629616,-0.04087325,-0.018377483,0.08291039,-0.0532946,0.06776975,-0.02741002,-0.02321729,0.06891741,0.009052957,0.067135796,0.04697979,-0.044276267,0.15815337,0.076272026,-0.028645331,0.039340463,-0.014144968,0.03505983,0.05049556,0.0257798,0.00034177213,0.054135904,0.032085516,0.08085823,-0.11736109,0.03989911,-0.035148256,-0.01071667,-0.0130433235,0.11593208,-0.0110462755,0.0068455758,0.060750578,-0.008833293,0.06410149,-0.08005727,-0.028115287,-0.02926866,-0.007670646,0.01109963,0.04632279,-0.008736276,0.028396053,0.018193623,-0.05225641,0.044746533,-0.044663336,-0.027035672,-0.04521179,0.06344524,0.08370012,-0.071634166,-0.01097753,-0.02267994,-0.016845737,-4.1401848e-33,0.100741476,-0.055546694,0.019927356,-0.059283696,0.04293279,0.031699736,0.10491494,-0.0576241,0.006489663,-0.03997208,0.041574843,0.035226848,0.053258996,-0.08041204,0.040898897,-0.018719452,-0.00013225962,-0.0021351485,0.053364094,0.012800925,0.07779187,0.053662203,-0.043563776,-0.014244502,0.052772976,-0.07397516,0.011570501,-0.031408224,0.024439834,0.020763196,-0.061155252,-0.0025808348,-0.048549127,-0.03750055,-0.003974729,0.0630811,-0.022379043,-0.02530607,-0.019427573,0.017162526,-0.01851308,-0.03490079,-0.022759039,0.08975325,0.030450808,0.06679377,-0.103839904,0.04153871,0.030310787,0.017286057,-0.035588663,-0.041135147,-0.022695059,0.018630873,-0.0054684794,-0.0122410245,-0.0074016266,0.028243009,0.005877118,-0.01551323,-0.049585152,-0.06885621,0.079881266,-0.009200487,0.006981392,0.090175405,0.011310727,0.09575716,0.040998597,-0.025973015,0.08392444,-0.0256739,-0.012590514,0.0998144,0.04998626,-0.06652306,-0.05438309,0.10735121,-0.0488232,0.025899615,0.09391896,0.008759515,0.03278228,0.016524935,0.054514997,-0.024203883,0.019130746,0.025475426,-0.083016545,0.0317422,0.0018408224,0.044387396,-0.060083345,-0.034361906,0.018667331,-3.2121296e-08,-0.006857562,-0.06731316,0.020529866,-0.028168567,0.08427672,0.007373295,-0.043333855,0.0044374564,-0.0044612433,-0.07914426,0.005102437,0.10949331,0.050258968,0.050335236,0.008983479,-0.113243975,-0.05313365,0.013558469,-0.07626409,-0.008655307,-0.067664824,0.023835402,-0.10138198,0.05953831,0.006549667,-0.005412289,-0.023361145,-0.0062415553,0.055359587,-0.036272485,0.014982577,-0.014348351,-0.005713554,0.001608423,-0.05847661,0.06044756,-0.012372222,-0.024074048,-0.019013977,0.031520795,-0.06252513,-0.053939167,-0.0018938225,0.017723866,-0.045347802,0.027123654,-0.0794676,0.0034714844,-0.0040927087,0.023108177,0.0427539,-0.028567225,-0.03658781,-0.05839168,-0.036702443,0.0022350915,0.017600087,-0.07632162,-0.004588117,-0.07176055,0.029490601,0.04524815,0.16404547,-0.0023040571 +1.14.13.64,Requires FAD. The enzyme from Candida parapsilosis is specific for 4-hydroxybenzoate derivatives and prefers NADH to NADPH as electron donor.,384,1.0,-0.05789358,-0.021833258,-0.06048813,-0.09665024,0.013528891,0.018595057,-0.061659344,0.11761751,-0.021547658,0.0066518392,0.030582892,-0.02080104,-0.10117858,0.110109575,-0.0567298,0.059212107,-0.011476789,-0.0015400392,-0.0032820774,0.013309025,0.05527511,0.007256045,0.071918376,-0.040700592,0.033933185,0.0077318167,0.03798307,0.0005588806,0.061455444,-0.026863465,5.4538108e-05,0.058439422,-0.06989139,-0.05721598,0.007994736,0.05937686,0.028745849,0.013718027,0.048245706,0.044866744,0.043058556,-0.03211568,-0.06280927,0.010501976,-0.0020684053,-0.011787822,0.0674765,0.068593584,0.06196935,-0.023539534,-0.020034987,-0.022138031,-0.0204814,0.04176176,-0.056598727,0.0030241404,-0.009970209,-0.027641332,-0.0060667335,-0.03540482,-0.08201226,-0.028796474,-0.012026076,0.037729483,0.022782912,-0.044998784,-0.0048917024,-0.030513614,0.0029064124,0.007498357,-0.04393215,-0.061886206,0.050092477,-0.006052474,-0.0033288158,0.028821098,0.038027186,-0.1224981,0.035781253,-0.008775503,0.040155075,-0.017597307,0.060033027,0.098304406,0.099641584,0.01289899,0.021774272,0.010327345,-0.013165009,0.02541472,0.034067146,-0.027575508,0.018446721,0.061743066,-0.130546,0.10664995,0.016341217,0.029835692,0.005228285,-0.02523653,0.004980894,-0.0075848517,0.01381543,-0.007711756,-0.0101822745,-0.01676246,0.022760551,0.091539,-6.860879e-05,0.013557993,-0.04808659,0.019573348,0.011750124,-0.06940707,-0.05801953,0.0065960237,-0.03440364,-0.048790522,-0.011805562,-0.11220555,-0.03576951,0.054873366,0.047887977,0.0001240018,0.05227409,0.011808229,-0.07449725,1.922457e-33,0.0936217,0.061836053,-0.044504113,-0.03296975,-0.0061197043,0.015351141,-0.083603695,0.013813495,-0.032477535,-0.049471382,-0.07664511,-0.09683675,-0.043357633,-0.009141051,-0.03614109,0.055204127,-0.015564816,-0.05406543,0.027118674,-0.014871965,0.05203999,0.017341455,-0.011320188,0.021395423,0.019834459,0.009216989,0.008408484,0.10818839,0.037753828,-0.008101112,0.014788045,-0.09169399,-0.06846317,-0.0060939966,-0.016785169,0.08493115,-0.02427894,-0.07447931,-0.031431947,0.004174947,-0.020093234,0.0543465,0.026308212,-0.03338518,0.09209077,-0.05810632,-0.028733132,0.04034097,-0.018634666,0.09410092,0.016714767,-0.02677679,0.087495096,0.03694359,-0.0383945,-0.036776535,-0.09340208,-0.01343591,0.03638769,-0.0007663542,-0.029874597,-0.0007340922,-0.01782564,0.123735204,-0.024998562,0.009176794,-0.023005193,-0.02731031,-0.014665984,0.07950877,-0.075744145,-0.0119363945,0.010278026,0.0018290253,0.092286065,-0.1325108,0.005851976,-0.05102196,0.06620946,0.0045085894,0.013375543,-0.089635976,-0.018613247,0.028665923,-0.031129757,0.024188112,0.032053694,-0.016068047,0.035730395,-0.021241857,0.058792736,-0.08763462,-0.016668301,0.014221782,0.033014454,-2.808445e-33,0.081907585,-0.036443148,0.097817935,-0.04227437,-0.019199848,0.06581981,0.083044566,-0.061515927,0.06695213,-0.053123754,0.02771469,-0.042316966,0.034339905,-0.03920444,-0.0324542,0.020762933,-0.10949347,-0.058594998,0.025503939,-0.025155822,-0.039667718,0.1500051,-0.03905564,0.048140254,0.052578256,-0.037129667,-0.028198509,0.029862437,0.019854525,0.05803162,-0.022684949,0.03629728,-0.0804324,-0.021596236,-0.04390018,0.07490822,-0.056378238,0.069341116,-0.05513564,0.04513724,0.010102234,-0.035254158,-0.06161122,0.08405694,-0.0018622996,0.10870137,-0.07798826,0.022760082,0.08988671,-0.04226342,0.004916234,0.037411626,-0.01030493,-0.023194466,0.07737899,-0.0016020419,-0.02333567,-0.0051970286,0.021721719,-0.046352547,0.005300488,-0.068903476,0.03837166,-0.04469372,0.061855815,0.017289022,-0.036425572,0.034761623,0.014582386,0.03826303,0.056282476,0.05701696,-0.0022658764,0.060761135,-0.0024573663,-0.049352746,-0.066616334,-0.03690879,-0.027429564,-0.002801168,0.08317864,0.009979461,0.025860688,0.031695314,-0.06268432,-0.016232092,0.06909168,0.04019751,-0.08686966,0.008821205,0.02814843,0.07960976,0.035532124,0.06269581,0.04127314,-2.8399155e-08,0.046129238,0.029274194,0.01916947,-0.09680157,-0.053184077,0.047929894,-0.02401903,-0.015499045,0.06879158,0.01053453,-0.061120845,0.14821865,0.02200822,0.09832964,0.041045103,-0.077104405,-0.07929902,-0.012314974,-0.071850225,-0.036795266,-0.094266295,0.032263223,-0.14267172,0.055543315,0.03408309,0.008828033,0.046639413,-0.01789665,0.036037143,-0.039536547,0.01106328,0.015965238,0.04229505,-0.027606605,-0.05067618,0.096301444,-0.026592817,-0.03735506,-0.007384532,0.013503805,0.024241304,-0.09801513,-0.0155584365,-0.015249278,-0.047718383,-0.05258031,0.025695119,-0.050379463,-0.03812469,0.013494984,0.08204406,-0.047655422,-0.006117269,-0.099241346,-0.03251022,0.0009083172,-0.0646451,-0.041318785,-0.021347066,-0.12667792,0.035382632,-0.022617707,0.08693839,-0.044231363 +1.14.13.65,3-Methyl-quinolin-2-ol is also a substrate. Quinolin-2-ols exist largely as the quinolin-2(1H)-one tautomers.,384,1.0,-0.019955771,-0.060319323,-0.02077629,-0.08616034,0.107815355,-0.08533193,0.0481663,0.0231876,0.005696812,-0.015952485,0.038497355,-0.043720458,-0.11407534,0.041647907,0.06460689,0.057845213,-0.08083226,-0.009411707,0.061516445,-0.01674238,0.024340773,-0.062016606,0.026768217,-0.014587236,0.0023764723,-0.008464799,0.01643919,0.0930712,0.091394834,-0.053788356,-0.048597112,0.0103864595,-0.040793702,-0.017251283,0.03382261,0.039559036,-0.010788592,-0.037800606,-0.04846769,-0.0062763975,0.056068785,8.409048e-05,-0.0043773353,-0.0047005704,-0.008413355,-0.009297639,-0.0019726388,0.039079066,0.013574227,-0.031187972,-0.02502481,-0.062153067,-0.008047464,0.030413331,0.03183057,0.07033363,-0.07612478,0.0897401,-0.043759838,0.084071636,0.050356567,-0.025871016,-0.06588493,-0.018166568,0.066156894,0.09768166,0.022806069,-0.046793025,0.018262912,0.026913747,-0.04073908,0.007944889,-0.04693065,0.017723292,0.041322365,0.05171038,0.028287185,-0.011831865,0.011972251,0.02470719,-0.06652006,0.044408064,0.03864799,0.032725982,0.015677094,-0.0026648764,-0.053315796,0.026134891,-0.026087798,-0.010233725,0.025645342,0.026447063,-0.0015410399,-0.02754082,0.0050779646,0.056201614,-0.0094298385,0.0151625415,0.06894604,0.04466338,0.010123596,0.031873263,-0.04014038,-0.045831952,-0.029255535,0.08327853,0.035420325,0.030511377,-0.07025329,0.03389847,-0.025606237,-0.023770124,0.10409137,-0.067641735,-0.06980273,-0.033051375,0.005604864,-0.021912172,0.045599233,-0.035584655,0.016084505,0.040247474,-0.027318405,0.009071976,-0.021299755,-0.018861687,-0.024382917,2.2208013e-34,0.0012687342,0.090720974,0.028084986,0.0030285793,-0.032557346,0.018447641,-0.026120974,0.025696134,-0.061262697,-0.032610454,-0.11585002,-0.09116474,0.0041780844,0.026354698,0.04269438,-0.035348102,-0.0027045961,0.006944992,0.04742436,0.02799625,-0.028135426,0.07175579,-0.055752873,-0.053364098,0.03375466,-0.048218742,0.0078118113,-0.026869178,-0.03543548,-0.042803824,0.030077945,-0.03943052,-0.013518339,0.016312415,-0.005500742,-0.02476356,-0.06587855,0.006680888,-0.024274379,0.059997752,0.019892339,0.06075808,0.07343647,0.022607505,0.012493587,-0.0851533,0.005519423,0.005664975,0.054026045,-0.10726475,0.06596382,-0.031629764,-0.027780917,-0.09051641,-0.018598806,-0.026793508,0.024343915,-0.068893895,0.029468812,0.04255568,-0.05165161,0.000942742,-0.050541665,0.01757323,-0.0067698373,0.080368094,-0.09144545,-0.0916935,0.00054485863,0.06449122,-0.049316496,0.018682498,0.04230841,-0.046501964,0.0032673036,-0.05918449,-0.043404333,-0.07385163,0.10986317,0.0022054904,0.05288517,-0.023901917,-0.015793486,-0.004907751,-0.13936467,-0.042241767,0.0016600469,-0.073042296,0.08537337,0.06263927,-0.049126435,-0.037507698,-0.015892873,-0.049261704,-0.025247743,-1.8748784e-33,0.059076402,-0.046154667,-0.011114772,-0.03862674,-0.040059347,0.12355981,0.06400215,-0.04020271,0.007263949,-0.01865355,0.09132765,0.017937567,0.049504496,-0.009416633,-0.003609778,0.032241173,-0.055455595,0.036792982,0.068702504,-0.057426922,-0.024161123,0.087113515,0.017699521,0.07561986,0.020759992,0.03698145,-0.002214241,0.016218014,0.05278716,0.14919613,-0.057421237,-0.097445324,0.074633926,0.02037983,0.04645578,0.07284623,0.06861542,-0.01047463,-0.1094072,-0.03822754,-0.0012284743,0.029140115,0.0661837,0.046505623,-0.08453983,0.06120417,-0.052303825,-3.1393713e-05,-0.14065853,-0.0447974,-0.023059614,0.020086598,-0.08474289,0.004855605,0.03707091,0.107621714,-0.091331825,-0.04601175,0.047058728,-0.00339828,-0.018573029,-0.049215585,-0.0076006744,-0.06104382,0.11063956,0.046772636,-0.09060948,0.059913144,-0.010118149,-0.04153217,0.007051264,0.05471116,0.024691595,-0.010588072,-0.038456228,-0.012023272,-0.055585,-0.030968841,-0.042222004,0.034740154,0.05347507,-0.007865496,-0.009340486,0.022428673,-0.04794676,-0.05900542,0.060843322,0.12055569,-0.0024083725,0.019215722,0.041808467,3.4440935e-05,-0.05698437,0.12875442,0.07237072,-3.4384716e-08,0.048539788,-0.024616908,-0.010903014,-0.026284873,-0.13984908,-0.021040786,0.063233264,0.0038223623,0.030217636,0.011699853,-0.005727187,0.0578227,-0.03774561,-0.031120263,0.066427484,0.02722608,-0.07461802,-0.015054076,-0.04260231,-0.0018811373,-0.04619616,0.030957218,-0.1030249,-0.02416353,-0.0428797,-0.030930689,-0.010173767,0.104753844,-0.0012927991,0.018804708,3.0005964e-05,0.00537771,-0.0028424931,-0.02166582,-0.003563366,0.034534708,-0.050088737,-0.03559537,-0.023012647,-0.018756438,-0.006208927,-0.013107138,-0.06426648,0.0170751,0.057665225,-0.046799783,0.00016797738,0.018514492,-0.03651726,0.015116052,0.046489365,-0.009640465,0.04792398,-0.0056472514,-0.061956927,-0.09202517,-0.07870488,-0.008846669,-0.041357543,-0.033811584,0.071325794,-0.0039612777,0.22495957,0.037080295 +1.14.13.66,The product decomposes spontaneously to 6-oxohexanoic acid (adipic semialdehyde).,384,0.99999994,-0.028350148,-0.026966853,-0.04414192,0.09112939,0.1258491,0.04199307,-0.05952687,-0.026386386,0.03752247,-0.024385467,0.018791646,0.0032044537,-0.105851956,-0.019251335,-0.0077841496,0.05186618,-0.11724165,-0.026307736,-0.12332756,0.0584905,0.022730269,-0.00037477896,0.036642652,0.058245264,0.09717932,-0.0023066485,0.115663126,0.05088405,-0.01903495,-0.081371255,0.034047574,-0.0028585978,-0.00910418,-0.037212588,0.08760041,0.065746725,-0.032038372,-0.068760514,0.02560615,-0.013977537,0.042680163,-0.095911786,-0.068608984,-0.047211673,-0.015921377,-0.026590925,-0.03248248,0.06316939,0.044446543,0.031947747,0.007590808,-0.025826484,-0.031494163,0.03929932,-0.01791865,-0.062197015,-0.03894372,0.012841545,-0.010493596,0.065631405,0.051493343,0.023566775,-0.07077501,0.022587905,0.009824111,-0.07451969,0.016233943,-0.09219037,0.05315364,0.027497586,-0.057484426,-0.055928458,0.002458548,0.005461347,-0.0031519374,0.058623426,-0.034445073,-0.122976646,0.057182282,0.015129965,0.051416434,0.057162385,0.039038062,0.09856758,0.009605856,-0.05874891,0.048772864,0.0050443676,-0.036406446,-0.00027393104,-0.06009181,0.08420815,0.0013721484,-0.037724663,-0.028466536,0.03706794,0.0665288,0.09999787,-0.011195187,0.034568574,-0.053980038,0.030344453,-0.05070395,-0.1164098,-0.052194927,0.021590691,-0.1314413,0.052342806,0.05733791,-0.008969274,0.015163471,-0.015562607,0.04610991,0.042798314,0.004535352,0.0904236,0.008893634,-0.013511129,-0.05938648,0.0035846287,-0.07019603,0.019608147,0.12384124,0.027352542,-0.09268343,0.009226064,-0.0038066613,5.523034e-34,0.024755301,-0.051409427,-0.035080068,-0.011077179,-0.01587453,-0.093585454,-0.077789314,0.03142254,-0.04046642,0.03557446,0.009375421,-0.06573331,0.024906125,0.0020579644,0.0063464395,0.025862636,0.001929432,0.016418202,0.01930983,-0.020792684,-0.030501636,0.11498286,-0.010837873,0.0020587246,-0.05062469,0.02081086,-0.0398304,-0.018193496,0.04340049,0.011967687,0.08596907,-0.013584815,-0.07793464,-0.06331539,-0.04158032,-0.026074313,-0.044583775,-0.0049207457,-0.00720387,0.028021036,0.074266806,0.010082193,0.030846162,-0.009900818,0.030132119,0.0010043415,0.042917576,0.084488705,0.034806047,-0.02204553,-0.010576812,-0.04014944,0.061317846,-0.0005962814,-0.02648168,-0.04317314,0.0072659943,-0.020596985,0.08077519,0.013132616,0.0074959453,0.05851778,-0.05315799,0.05507499,-0.039779644,-0.06681672,-0.029022813,0.004446212,-0.060724333,-0.0153650595,0.012828316,-0.004796727,0.051895943,-0.061259214,0.029762216,-0.064022,0.028633488,-0.012156732,0.044173457,-0.0026654545,0.028898804,-0.007863843,0.027762882,-0.02455298,-0.095683545,-0.019483319,-0.032626696,-0.018370392,-0.041422125,0.07015586,0.017823923,-0.05269862,-0.09827492,-0.03223359,0.010728166,-2.1128684e-33,0.15566532,-0.09837551,-0.05919524,-0.08292696,0.009557229,0.034050576,-0.020221237,0.05506109,-0.02410518,-0.018339712,0.12579975,-0.016745131,0.054246902,0.0045115515,0.069688484,0.024137503,0.015924687,0.07003718,0.043062367,-0.010466233,0.03723619,0.042701915,-0.105173856,0.02882901,0.06608106,0.025665408,0.07007565,0.003558161,0.06714141,0.047334686,-0.011335047,-0.03843387,-0.042813845,-0.0046171965,0.039610937,0.056969594,-0.077025436,-0.0981859,-0.032123204,0.051647037,-0.024325717,0.020665059,-0.033166505,0.021524401,0.12275681,-0.026006302,-0.058840424,0.010050851,0.02119545,-0.015109555,0.083216175,-0.020634636,-0.1006094,-0.0029203936,-0.061975542,0.069451764,-0.037014335,-0.015275558,-0.0076892804,-0.05076963,-0.0117693385,-0.047691938,0.042571783,-0.03382208,-0.040310647,0.08836338,0.014238723,0.044379547,-0.0029818148,-0.06944076,0.08040058,0.028322004,-0.017820084,0.027291447,0.04456067,-0.044286814,-0.038255613,0.005274808,-0.006871123,-0.018534042,-0.04532834,-0.0042377273,-0.028426554,-0.026033139,0.04848016,-0.069781,0.0007220731,0.021601316,-0.050974254,0.023209212,0.08381889,-0.03568878,-0.009867933,0.084448665,0.10054318,-2.7855602e-08,0.02139236,-0.0800517,0.09783844,-0.0130061,0.007582327,0.011428326,0.10126121,0.015711986,0.004046879,-0.03592087,0.00854214,0.06348648,-0.01471323,0.041001786,-0.025874091,-0.0983509,-0.07358891,0.048340023,-0.036615267,-0.041155484,-0.07581888,-0.049395718,0.018169394,-0.05612979,-0.038853798,-0.044785433,0.023985235,-0.029548507,-0.004503374,-0.038686447,0.022381347,0.050196286,0.010887325,0.01533799,-0.009266092,0.040160615,0.025489632,-0.016649013,-0.10898652,0.008874532,-0.03362022,-0.077847905,-0.08153817,-0.023585903,0.019561077,-0.023995783,0.007497884,0.043077745,-0.0019830605,0.054951638,0.074698456,0.021585034,-0.036137678,-0.007934889,-0.02009715,-0.030112889,-0.00044281027,-0.04644533,-0.010290862,-0.034245975,0.06049283,0.09368244,0.1642973,-0.05705161 +1.14.13.68,"This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.41, tyrosine N-monooxygenase and EC 2.4.1.85, cyanohydrin beta-glucosyltransferase.",384,0.99999994,-0.124042,0.037522875,-0.11829676,0.0066544707,0.049494173,0.039238665,-0.13057606,0.018695839,0.03939052,-0.046314944,0.114369646,-0.052857265,-0.13889122,-0.08502916,-0.07198505,0.014309284,-0.006713867,0.050585177,-0.022685533,-0.12649928,0.05263314,0.076804295,0.04477219,0.008954041,0.04087012,-0.009408302,-0.012517221,0.017273769,-0.03775523,-0.015910292,-0.010339011,-0.008049785,0.026592126,-0.01908521,0.017175842,0.062517755,-0.014180149,-0.08160226,0.08092579,-0.05498072,0.078466326,-0.083644494,-0.00551946,-0.04872723,-0.002075618,-0.032281667,0.009583027,0.077313386,0.025358945,-0.016614234,0.04082643,-0.04014143,-0.01145049,-0.059662584,0.029283365,-0.017018646,-0.09478466,-0.05092914,0.010978941,0.07635651,0.007221088,0.041966476,-0.086677976,0.047033966,-0.029298509,-0.04116931,-0.027694603,-0.100071214,0.024753971,-0.06294508,-0.007713706,-0.14036213,-0.0054812534,-0.0035967152,-0.07595018,0.11099035,0.015328294,-0.016718663,0.035820074,-0.045361325,0.09608381,0.03598128,0.11540456,0.04616017,-0.02570582,-0.061671514,-0.017047325,0.08352858,-0.030807594,-0.017887441,0.123754956,-0.026959632,-0.030758196,0.035051983,-0.0008930501,0.053779867,0.08896887,0.045612726,0.0053391703,-0.018335896,-0.017720792,0.0432623,0.029714173,-0.03965974,0.0027673126,0.051060133,-0.02041536,0.07951467,0.081485815,-0.035695106,-0.0119048245,-0.024513068,-0.031736467,0.025620906,-0.0032980079,0.04291585,-0.030714415,-0.025435464,-0.09456124,0.0015827736,0.02104657,-0.026382316,-0.0022497096,0.115137756,-0.0204708,0.028980289,-0.032347664,2.9439744e-33,0.063890435,0.007568775,0.014065082,-0.06783389,-0.00062035077,-0.05627482,-0.017368622,0.009736077,-0.020786779,-0.069660276,-0.07939697,-0.07296192,0.010458803,0.028637799,-0.053294044,0.0048217117,-0.05805278,-0.02669866,0.120712504,-0.015794758,-0.01798396,0.039256703,-0.06082895,-0.012048049,0.019308945,0.04631905,-0.009495043,-0.021506652,0.06803634,-0.01938728,0.03421961,-0.091708966,-0.02808839,-0.024094664,0.044169597,0.023487769,-0.01791948,-0.03887524,-0.03690673,0.039061405,-0.088396214,0.032435454,-0.0033294256,-0.044162463,0.011138694,0.0032189416,-0.049707953,0.06324574,0.020952528,0.06477327,0.07219086,-0.021423211,0.055970065,0.08040224,0.012437881,0.058177967,-0.01317922,0.025213141,0.010465144,0.060668334,-0.0050404705,0.028503397,-0.0067339805,0.008920908,0.011591652,-0.011064444,-0.059242994,-0.041743804,-0.07145591,0.04959981,-0.021508204,-0.013353484,0.04642262,0.023904376,0.01069646,0.03613947,0.0021043199,0.0113098845,-0.02761741,0.006458503,-0.008413129,0.048695054,0.014660188,-0.034770187,-0.034028456,0.06972917,-0.06000984,-0.054825034,-0.011059762,0.031018637,0.020828744,-0.036912847,-0.07909344,0.035435274,0.0134304855,-4.8619688e-33,0.054068934,-0.068156,-0.0054805786,-0.083034515,-0.052460667,0.06417594,0.017493352,-0.047486063,-0.0051865946,0.04897033,0.08852399,0.021390997,0.066344,-0.07776842,-0.004266712,-0.056238998,-0.046326764,0.15081953,-0.027579801,0.07202981,0.024363799,0.055174366,0.014625026,-0.035267197,0.04750715,-0.025510995,-0.027673576,0.029406568,-0.020405814,0.028583027,-0.022619069,-0.0032611177,-0.059497908,-0.03248598,0.0871002,0.06682817,-0.014045532,0.013814232,0.020015324,0.015591668,-0.050805654,0.04451122,0.01268879,0.057409286,0.11887656,0.065426,-0.08403215,0.031387787,-0.06989358,0.036298793,0.0038796414,0.08119209,-0.020344991,0.0582669,0.026351796,0.044648547,0.10244319,-0.0049011074,-0.041639186,-0.031683017,-0.06405273,-0.043334667,0.018022109,-0.040892307,0.063100696,0.035023287,-0.03396458,0.05556487,0.03357214,0.020384647,0.06970842,-0.061565097,-0.006811033,0.031701237,-0.039123602,-0.03649027,0.009085845,-0.045847427,-0.037434053,-0.030486114,0.016521985,0.037316658,0.07047637,-0.014530784,-0.04761703,-0.036132816,0.100627005,0.14717841,0.01717073,0.07832512,0.013196042,0.0040562158,-0.061697334,0.03855118,0.021961305,-3.640135e-08,-0.040707037,-0.043995738,0.05853758,-0.07329382,0.014004932,0.06682837,0.05379314,0.013874075,0.026259288,-0.0050865677,0.024530197,0.09523571,-0.06434502,-0.0424218,-0.051238585,-0.030159276,-0.015908025,0.010926213,0.028459571,-0.038213383,-0.036372803,-0.012847397,-0.08547664,-0.01988463,-0.013601486,-0.12004715,0.028808923,0.07822213,0.011343479,0.0073610186,0.009202702,0.0014578756,-0.018111987,-0.074069045,-0.019214027,0.023364961,-0.039969258,-0.014461133,0.040379375,-0.0014413272,-0.12983221,-0.047279924,0.03318286,-0.0056875376,-0.001596366,-0.015884789,0.04394173,0.027983006,0.016039921,0.068754315,-0.04170538,-0.08252953,0.01588575,-0.10151986,-0.057747215,-0.044121288,0.016343351,-0.02615549,0.0009317109,-0.028750403,-0.013672035,-0.017527537,0.124209665,0.0057002893 +1.14.13.69,"This bacterial binuclear non-heme iron enzyme is a multicomponent enzyme complex comprising an oxygenase, a reductase, and a Rieske-type ferredoxin. The enzyme from the bacterium Xanthobacter sp. strain Py2 contains an additional small protein of unknown function that is essential for activity. In general, the enzyme oxygenates C2 to C6 aliphatic alkenes, although enzymes from different organisms show different substrate range. With propene as substrate, the stereospecificity of the epoxypropane formed is 95% (R) and 5% (S).",384,1.0000001,-0.019195387,-0.02130252,-0.14144866,0.020241534,0.12642422,0.0069114277,-0.032379676,0.06357364,0.01421034,-0.02155879,-0.024071598,-0.088969156,-0.026881104,0.007097872,-0.002916005,-0.0024849186,-0.08392476,-0.032511707,-0.0017348652,-0.023482284,0.040304575,0.014631597,0.053373072,-0.012577929,-0.014586223,0.025509965,0.08080355,0.034668457,-0.028979031,-0.06077208,0.04010126,-0.025325615,0.055184223,-0.031278796,0.028411468,0.097909346,-0.007699686,-0.024482662,0.01332189,-0.007936234,-0.015092081,0.011926221,-0.039730083,-0.06620564,-0.028287904,-0.0028442587,0.03941707,-0.0053850007,0.0038802368,-0.036044106,0.031327955,-0.03923038,-0.06427631,0.047619015,0.035221186,-0.047320493,0.0075253868,-0.050199922,0.011655764,-0.054803915,0.08541963,0.019540919,0.012363786,2.6428033e-05,-0.04801693,-0.042261582,0.03082697,-0.07677297,-0.029576665,-0.09346669,-0.07665665,-0.03683873,-0.037327208,0.056018516,0.006988541,0.0073931627,0.047108863,-0.02840516,0.040519517,0.04481515,-0.030813659,-0.012923636,0.00065668876,0.07491266,0.026127705,-0.015482105,0.021253759,-0.012384128,-0.02948809,0.05559695,-0.0040160124,0.05997282,0.012007886,-0.040579725,0.009392913,0.0041944077,0.048972506,0.05544436,0.057154465,-0.010633697,-0.030239392,0.046814755,0.0029452953,-0.11266733,-0.06944213,-0.032946702,0.02175056,0.13247013,0.079198375,0.008982148,-0.004514863,-0.044608366,0.05991249,-0.024530604,0.00090556685,0.07282052,0.03247675,-0.028525038,-0.053719677,0.053061597,0.056474954,0.04078685,0.032652535,0.04457638,-0.059195932,-0.07336351,-0.09603161,4.129838e-33,0.002897317,0.034112435,0.008674547,-0.067948036,0.044735793,0.04303632,-0.098630674,0.03005141,0.00047193802,-0.0048815846,-0.09355216,-0.087204374,0.02874561,-0.018150538,-0.050283868,-0.08117155,-0.059472136,0.0633574,0.024627285,0.013758528,0.008067773,0.023242969,-0.023349516,0.01639439,0.03621119,0.026400222,0.027238032,-0.032066956,0.0037766935,-0.026829395,0.026006041,-0.09217573,-0.099569194,-0.023686046,0.0063220607,-0.033394445,-0.022255361,0.014832738,-0.035504866,-0.001746576,0.003487703,0.02052157,0.025241103,-0.060123537,0.07583507,-0.08506032,-0.07281092,0.11918745,0.020253306,0.07437254,0.04639594,-0.026434282,0.046876747,0.025768334,-0.07110151,0.07677369,-0.044427022,0.03946105,0.059064575,0.013666957,0.102288984,0.13732691,-0.047702655,0.0268624,0.015902316,0.04793416,-0.028688619,0.00022859409,-0.0004313761,0.10095174,-0.057793465,0.019335495,0.057473306,-0.017601212,0.06086426,-0.03997581,-0.1260738,0.002745865,0.11052898,-0.0016670345,-0.011175384,-0.009777929,0.031139081,-0.03835776,-0.14102206,-0.0112128565,-0.069170415,0.027435558,-0.028462227,0.077141434,0.097289026,-0.11569093,-0.09092338,-0.037519857,-0.020317415,-4.2324758e-33,0.06730774,-0.07843998,0.091636896,-0.06471913,0.010460209,0.07245266,0.020091938,-0.031122364,-0.04928057,-0.044488486,0.12967576,-0.032878153,0.038434494,-0.020443685,0.043681823,0.07317109,-0.02084942,0.07189241,0.04841369,0.0072697825,0.018286074,0.012343811,-0.019086549,0.0024223302,-0.036821317,-0.015679337,-0.013584379,0.037910122,0.111462995,0.06639005,-0.0064518144,0.012757263,-0.05645109,-0.07723796,-0.07288753,-0.017715756,-0.04766391,0.007741933,0.02452352,-0.016041266,0.011361379,0.0013400272,-0.066188924,0.08621768,0.027482823,0.08761687,-0.042525347,-0.02570536,0.05025208,0.0102773225,-0.025644373,0.0136060985,-0.04577089,-0.029108934,0.01459795,0.044136453,-0.029193174,0.0109202685,-0.036625404,0.004184325,-0.01255006,-0.05604002,0.081654735,0.091694504,0.04743636,-0.0068525188,-0.04697706,0.06903522,0.042632397,-0.03838017,0.12526491,-0.014441868,0.012557351,-0.02440283,-0.017556962,-0.026917256,0.038386356,0.023059351,-0.007406894,0.03542458,0.04970043,0.019723779,-0.014616441,-0.051596016,0.0055905464,-0.07871264,0.01090791,0.06644672,-0.009222012,0.00032153135,-0.03008487,0.04365665,-0.004865699,0.03779312,0.10472818,-4.4174254e-08,-0.043956693,-0.105677,0.0938037,-0.04669429,-0.021967083,0.017125731,0.0639279,-0.05065212,-0.039686926,-0.028303634,0.022864653,0.030437734,-0.015081812,-0.050856005,0.07680259,0.046274025,0.0023833439,0.065669306,0.013000505,-0.03911805,-0.03291366,-0.016826246,-0.08082336,-0.0017740378,-0.005576622,-0.060272053,0.0005878252,0.0023435652,0.009702865,-0.01758202,-0.042747926,0.077934705,-0.027057154,-0.03417096,-0.09157343,-0.003032357,-0.061501324,-0.014687873,-0.06788845,-0.001775869,-0.016360454,0.004070401,-0.07714348,-0.031032927,0.04512898,0.034348883,0.027949234,0.026572961,-0.029452614,-0.05942246,0.10206296,0.011123867,0.019123876,-0.023069035,-0.065874614,0.14941978,-0.036291096,-0.043545913,0.0047876453,-0.027874494,0.027284153,-0.015574825,0.16085263,-0.05248178 +1.14.13.70,"This heme-thiolate (P-450) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses two successive hydroxylations of the 14alpha-methyl group, followed by elimination as formate, leaving a 14(15) double bond.",384,1.0,-0.031954423,0.039940335,-0.057248577,-0.052134965,-0.0012877407,0.03499958,-0.06955726,0.09007831,-0.0012900666,-0.009460849,0.010832598,0.005446651,-0.08290217,0.028351031,-0.013894757,0.04203332,-0.08402647,4.6047993e-05,0.024340168,-0.05132421,0.04106033,0.013950471,0.0025324484,0.016171418,-0.0343579,0.07128643,0.1114587,0.06225806,-0.020782601,-0.08204042,0.0031555316,-0.07456808,0.06802144,-0.024003213,-0.009646229,0.10625773,-0.100324735,-0.057774086,0.010836954,-0.0069855535,0.11522051,-0.09402506,-0.090496145,-0.021377396,-0.019377548,-0.059143435,-0.020916965,0.057010707,-0.027061129,-0.0015372229,0.0069328374,-0.09256555,-0.022730138,0.06633074,-0.02959563,0.0080212215,-0.00682633,0.03321751,-0.027743857,0.006508961,0.012187963,0.04514996,-0.09372326,0.025686393,-0.041139275,-0.0036667406,0.038463283,-0.041684408,-0.057310943,-0.0068506612,-0.031412333,-0.040894717,-0.03417071,0.026137536,-0.06629993,0.07225404,-0.052348085,-0.04177012,0.030020889,-0.021081273,0.046269182,-0.013558852,-0.021007825,0.09245838,0.092538275,0.0018289653,-0.03139503,0.037840623,0.011296257,-0.0073064826,0.008897243,0.048661362,-0.041852616,0.01338394,-0.123575725,0.07004834,0.006682385,0.03604706,-0.011245231,0.01106955,0.044946212,0.09172514,-0.051310584,-0.07141807,-0.11435772,0.005753775,0.023624998,0.019448906,0.055485196,-0.054131385,-0.057707142,-0.012920861,0.042868737,-0.04949304,-0.02492836,0.11934741,-0.038024675,-0.00043041876,-0.022022614,-0.06954423,-0.0265066,-0.044114944,0.02406465,0.06997785,-0.06792512,-0.009983372,-0.06475226,3.661093e-33,0.09633708,0.03057572,0.00076347066,-0.010042268,-0.006247987,-0.0049069864,-0.055658698,0.06076148,-0.079880826,-0.033978123,-0.02154669,-0.11509309,0.06850499,-0.012626926,-0.038730748,-0.10350889,0.021749735,0.08744268,0.060616646,-0.0075326716,-0.04451017,0.049619664,-0.04299213,0.038683318,-0.006937048,0.09171079,0.0005043316,0.04769051,0.04310334,0.009629445,-0.021627534,-0.021849249,-0.05433046,-0.04226465,-0.033261172,0.04351069,-0.027294781,-0.035807125,-0.006985837,0.0534031,0.036767043,-0.021306816,0.057714485,-0.027008658,0.043815326,-0.02380455,-0.103183195,0.055470306,0.074363455,0.036624562,0.06984747,-0.0060056834,0.079130836,0.040319297,-0.056917664,0.05416417,-0.032861408,0.036546834,0.030606428,0.035745177,0.15399203,0.053952627,-0.016048618,0.018626906,-0.04777785,0.06906828,-0.0076662353,-0.067849,-0.022167066,0.10843593,-0.020169416,0.07367734,0.026884032,-0.0058339466,0.029239522,0.014245491,0.027090425,0.052637726,0.04680968,-0.004654172,-0.042034008,-0.020735752,0.011577686,-0.031431206,-0.018963078,-0.016678406,0.011929976,-0.016061265,-0.0025545356,0.04778791,0.06576742,-0.084681146,-0.037679184,0.037083253,0.010553703,-2.9946259e-33,0.06979586,-0.09245346,0.050423898,-0.1052217,-0.05760743,0.051503673,0.03990104,-0.031035975,-0.03856798,0.006309833,0.12691143,-0.029223656,0.014689534,-0.03828814,0.024158001,-0.0063638194,-0.018468337,-0.010856318,-0.02267745,0.0020197453,0.04278646,0.075849146,0.01707903,0.073635384,0.04049667,0.03998481,0.016190382,0.009436802,0.08307469,0.057703476,-0.016574932,0.0041659144,-0.017507888,-0.008094302,-0.074343026,0.101345316,0.006042023,0.021178922,-0.0023013314,-0.009789076,-0.06046039,0.019050453,0.013654987,0.031083861,0.009210603,0.08409414,-0.021675445,-0.030998394,0.0018305784,-0.06270203,0.03248312,0.06638282,-0.03301704,0.037690368,-0.027777124,-0.01320913,-0.054786216,-0.041452825,-0.0064618764,-0.17358524,-0.017249092,-0.011956992,0.013396645,0.020763727,0.02350703,0.056443512,-0.052907534,-0.025446871,-0.008703461,-0.0064735194,-0.027333137,-0.014697242,-0.0014533646,0.08618036,-0.018651923,-0.029852396,0.021562576,-0.058170635,-0.008816217,0.008558865,-0.0051345467,-0.015029798,-0.045063406,-0.095956326,-0.06444033,-0.06470282,-0.0012693718,0.09164665,0.012151816,0.0473677,-0.044848263,0.082224414,-0.050628934,0.0750934,0.0711478,-3.962684e-08,-0.038027115,-0.10787871,0.017012388,-0.009905277,0.0005476994,-0.004928157,0.023482684,-0.022076236,0.09669351,-0.07175257,-0.047026772,0.046978947,0.013135043,-0.015429466,0.006910365,0.00044466383,-0.010736355,0.027935931,0.009041544,-0.066278115,-0.06415581,0.024457527,-0.009453539,-0.017009757,0.068468794,-0.042708665,-0.0785803,0.027123133,0.0071227504,-0.0070955995,0.053389583,0.061862573,0.0013200684,0.0071362504,0.024947094,0.12495918,-0.022323903,0.0038477962,-0.02954699,0.045596868,-0.017007751,-0.102741756,-0.054517128,0.027442304,0.008130948,-0.013335946,0.035976116,0.028237628,0.008275493,-0.013141807,0.0076425574,0.010234659,0.03083452,-0.0905119,-0.10162442,0.020349484,0.011013134,-0.054926645,-0.03520478,-0.053164314,0.052121192,-0.060037944,0.21921793,-0.02192957 +1.14.13.71,A heme-thiolate protein (P-450) involved in benzylisoquinoline alkaloid synthesis in higher plants.,384,1.0,-0.055777263,0.020926878,0.009115018,-0.04178794,0.024481747,0.11463632,-0.0729277,0.082461074,0.043801736,-0.03388618,0.019235691,-0.04350926,-0.028019324,-0.067941315,-0.03432766,0.0450359,-0.080111094,0.070596114,-0.0687282,-0.105726495,-0.07762844,0.09745435,-0.0029575943,0.032471795,0.04821614,-0.020264158,-0.025293263,0.049791966,-0.037141383,-0.022343677,0.0008417209,-0.016291901,0.031465773,-0.025187725,-0.052092228,0.056401204,-0.10212664,-0.07062409,0.07551471,0.03717492,0.07698447,-0.028912656,-0.118722536,0.037277598,-0.06631034,0.016541999,0.021397535,0.055102844,0.019391134,0.009405132,-0.011621721,-0.011633401,-0.043447595,0.06131651,-0.08404981,-0.018619198,0.0762827,0.16620213,-0.016299954,0.023935677,0.0006415826,0.05635516,-0.016815502,-0.017799858,-0.03919903,0.010121889,-0.06828093,0.0065060165,0.04572773,-0.03831681,0.00073943875,-0.071207896,-0.020680944,0.03096094,-0.057133894,0.10390321,-0.062020056,0.01800197,-0.036332715,-0.043752976,0.06406184,0.025007252,-0.020072056,0.08576931,-0.053136215,0.002031224,-0.016742362,0.05988118,0.020247525,-0.02911332,0.071001045,0.020924391,-0.06664253,-0.013550505,-0.08445251,0.13871244,0.07560583,-0.017099444,-0.029227635,-0.039901555,0.06401277,0.00050961686,-0.05080497,-0.060849097,-0.029685363,0.04820975,-0.034488667,-0.07413989,-0.028224176,-0.0806297,0.02968624,-0.025645712,0.029311178,-0.05102231,0.00506909,0.056838896,-0.0113510685,-0.0290382,-0.06008967,-0.032003142,-0.07234824,-0.028264709,0.05051288,0.0041760057,-0.045938563,-0.02931405,-0.06569577,5.3607084e-34,0.09396319,0.04068521,-0.030295638,0.03614814,0.021030424,-0.08289395,-0.080804445,0.04768293,-0.08460353,-0.027990503,-0.081195235,-0.07334883,-0.0029494197,-0.066346034,0.012495217,0.0061449204,-0.05832855,0.024067797,0.03724942,-0.038025748,-0.0900607,-0.010401075,-0.059300017,0.034495078,-0.033707365,0.10209582,0.037641518,-0.01299074,-0.026048236,-0.042990867,-0.06137288,-0.045132335,-0.024363652,-0.040694714,-0.0024237575,0.0053193006,-0.0039758286,0.001573653,-0.03537948,0.038850985,0.04739016,0.075687476,0.062612444,-0.0022263222,0.042610656,0.03525432,-0.11421204,0.022478376,0.005636855,0.051895335,0.010301172,-0.04029498,0.13812375,0.07798699,-0.032180134,-0.007388898,0.034828696,0.062430236,0.008862516,0.037453514,0.049478654,0.026821587,-0.012061847,0.05014315,0.0006346178,0.01953751,-0.070335746,0.011031871,0.052892406,0.09332429,-0.00031020393,-0.043510277,0.0329343,0.0070476886,0.05130118,-0.039730947,-0.024784219,0.023366215,0.039715663,0.044912267,0.008700076,-0.07252801,-0.01731515,-0.0071599274,-0.042459555,0.005469036,0.016051108,0.023415938,-0.011681385,0.046628483,0.064690635,0.016986808,0.033445347,0.0018499347,-0.008159567,-5.860185e-34,0.070594184,-0.06608269,0.026202599,-0.028210271,-0.03710234,0.025410566,-0.08770376,-0.017973041,-0.04347384,0.048938613,0.085413694,-0.0011185113,0.014512995,0.028597714,-0.024418829,-0.07594317,0.017673342,0.08594283,0.0027482526,0.060353637,-0.057425752,-0.0233625,-0.03964923,0.067215584,0.00501374,0.017981792,0.008732427,-0.012577863,0.02760903,0.034840655,0.04167582,0.0167401,-0.07354974,0.016790187,0.0059670946,0.03967127,0.047177482,0.014262596,0.004442885,0.05730883,-0.033079423,0.014850043,0.054368693,0.0039050025,0.048950706,0.03740887,-0.047856763,-0.025547469,-0.098620154,-0.011124824,0.096695706,0.02023421,-0.019230563,0.046907604,-0.014979303,-0.009845454,0.009734288,-0.005651683,0.015314129,-0.07237058,0.00436685,-0.037345465,-0.028847683,0.013691766,-0.06814129,0.108452275,-0.03377436,0.07254515,0.01714629,-0.0036662384,0.018689657,-0.017836435,0.0991081,0.08068612,-0.019830257,0.0063412464,0.09123127,-0.03154035,0.038060337,-0.035917852,-0.0027707976,0.03247047,-0.01890563,-0.080843054,-0.029536145,-0.030300027,-0.08747295,0.122016765,0.045527045,0.030118236,-0.011003842,0.03903126,-0.023198815,0.058674924,0.09370677,-2.4932868e-08,-0.027441854,-0.063728884,-0.012402838,0.028124675,0.0149259,-0.010619613,0.026446206,0.01291596,0.0645764,0.0039032227,-0.02178321,0.008098731,-0.054610927,0.058949307,0.043943837,-0.03555458,0.044246316,0.0660276,0.028940585,0.06970311,-0.051699303,0.08331082,-0.02096241,-0.06632733,0.06583492,-0.0998406,-0.014488229,-0.014771305,0.04843621,0.0051383595,0.08347089,0.045301918,-0.032475144,0.0022355262,0.06599347,0.023679547,-0.015306243,-0.034196053,-0.010246143,-0.035382245,-0.041273568,-0.051242698,-0.10404286,-0.044276416,0.011760399,-0.07098094,0.029952796,0.049568806,0.013642097,-0.022193462,-0.0040772054,0.00065216236,0.08367374,-0.15158337,-0.095703416,-0.02117107,0.034578983,-0.01902622,-0.024804488,-0.14037412,-0.014141614,-0.035700653,0.1331714,-0.037121527 +1.14.13.72,Requires cytochrome b5. Also acts on 4alpha-methyl-5alpha-cholest-7-en-3beta-ol. The sterol can be based on cycloartenol as well as lanosterol.,384,0.99999994,-0.047406778,-0.043372132,-0.04216573,-0.04115164,-0.029106349,-0.008608997,-0.039705202,-0.024739144,0.026512804,-0.027410699,0.017849278,-0.016783698,-0.07861671,0.004728391,0.025704607,0.047363095,-0.01995755,0.036078986,0.04603245,-0.03201217,0.025077272,-0.03799455,0.036083583,-0.010993012,-0.046419483,0.030157614,0.044214927,0.11371727,0.004692915,-0.11549265,-0.018781146,-0.018150952,0.039664574,-0.047896914,-0.063895956,0.04916237,-0.05393278,-0.043813303,-0.018710488,0.05235322,0.06274296,-0.034592543,-0.0050532664,0.012662954,0.043868426,-0.08074979,-0.023846125,0.013737865,-0.01342664,0.016775044,0.00857784,-0.07542789,-0.00022764997,0.023567649,-0.06603675,0.041960623,-0.07601522,-0.033258587,0.026449982,-0.019292183,-0.023452088,0.033468958,-0.050649166,-0.035727754,-0.06547303,0.053563174,0.011321998,-0.070002876,0.005457229,0.008457834,-3.399584e-05,-0.051909585,-0.05226063,0.08559563,-0.088900566,0.04842084,-0.019659637,-0.07032948,0.027309924,-0.06292128,0.0008916992,0.024571588,-0.05560534,0.13812962,0.14162022,0.03474004,-0.046697307,0.00049004453,-0.08030095,0.054730423,0.087189086,0.0016218664,-0.0048006177,0.00083063554,-0.024607753,0.0043593575,0.058084026,0.030086888,-0.043821927,-0.040446978,0.024154723,0.022258017,-0.07085959,0.024788545,-0.008790104,-0.038358122,0.031957053,0.0016353158,-0.0092619965,-0.07381515,-0.049178742,-0.08196028,0.041132167,-0.033954274,-0.033499856,0.04188021,0.016739303,-0.06481992,-0.035744708,-0.030172577,-0.009461133,0.039606296,-0.019021966,0.006783625,0.00027359853,0.08222109,-0.019625254,3.7276274e-33,0.08647679,0.054916516,0.0364967,0.13140427,-0.03653167,0.0387955,-0.02051932,-0.019633291,-0.05051326,-0.07877313,-0.027217772,-0.044358328,0.0054500643,0.03205007,0.017033445,0.070707045,0.05013803,0.014968703,0.07169422,-0.11041079,-0.018024221,0.09423911,-0.0755321,-0.07542064,-0.03744467,0.01554717,-0.009093821,-0.014361016,0.06398215,0.031379506,0.0014142982,-0.040439207,-0.03228091,-0.03415368,0.035500657,0.041950922,-0.041628543,-0.027637094,-0.039684497,0.08022984,0.06832757,-0.015185401,-0.010086366,0.0031309312,0.06992414,-0.0069596837,-0.1041784,0.08773486,0.07771198,0.07795741,0.067239225,-0.023726804,0.0026634592,0.048569784,-0.044462785,0.06532576,-0.042564925,0.013574697,-0.0034278824,0.05276973,0.0406997,0.09250605,-0.0028051992,0.07881602,0.037546713,0.044672146,-0.023058504,-0.13859916,-0.17159007,0.013823405,-0.021703437,-0.036635168,0.03832413,0.0374858,0.04106168,0.076242924,-0.003244389,0.028623255,0.007185631,0.0064550927,-0.046439916,-0.08366935,0.031442028,-0.029345566,-0.055755626,-0.007599952,0.048639275,-0.051636327,0.00068617717,0.019570325,0.030246254,-0.07928951,-0.062364567,0.05185712,0.0011149606,-4.420694e-33,0.022980995,-0.08416379,0.11585483,-0.0635,-0.072564855,0.047266748,0.008568999,-0.17332774,0.09827957,0.042064603,0.09577256,-0.014237107,-0.015227369,0.0030900561,-0.009179113,-0.0085666375,-0.03835077,-0.017266031,-0.002858019,0.015782759,-0.049230956,0.067495406,0.03762287,0.19218221,0.043130722,0.045201316,0.07883047,-0.016455848,0.070317715,0.019913267,-0.032997217,-0.008125333,-0.0119429855,-0.063435644,-0.086659595,0.032452434,-0.024186894,-0.0011257724,-0.03230435,0.017599627,-0.09827,-0.01899363,0.014063528,-0.018164614,0.055220883,-0.014877347,0.009505949,0.035848737,0.027142601,0.012234672,0.040802415,-0.0030773245,-0.027282715,0.06626587,0.044900034,0.047111556,-0.018528596,-0.028211735,0.0705254,-0.0695563,0.00090276764,0.031144466,0.032364774,-0.048852965,0.018339401,0.03856428,0.038879294,-0.006889318,0.04814772,-0.06709089,-0.007603805,0.034144603,0.081868425,0.060899753,-0.02290609,0.019848207,-0.017215304,-0.02204336,-0.027110176,-0.06431082,-0.041346584,-0.05504893,0.033137284,-0.016535081,-0.06321465,0.0062286365,-0.0046385187,0.028808955,0.044666883,-0.009317512,0.0067144996,0.006668786,-0.07496214,0.043857604,0.0029721325,-3.7597413e-08,0.07035032,-0.0035881598,0.028189948,-0.08137731,-0.08629297,-0.009122908,0.0439637,-0.0754613,0.08939017,-0.012713958,-0.029922387,0.09594841,0.05058271,-0.02823086,0.020472933,0.020787515,-0.0058962153,-0.0047096927,-0.010078935,-0.08468483,-0.06706831,-0.05271224,0.029486377,0.006484877,0.048081964,-0.09068999,0.026385088,0.060817562,0.057941485,0.025510872,0.09715804,-0.021237891,0.004014466,0.025116432,0.046956938,0.08899108,0.011635728,-0.045218688,-0.019667525,0.11247215,-0.03683526,-0.03434187,-0.010296595,0.0026146444,-0.031591956,-0.046095803,0.03635156,0.03564543,-0.0055586607,0.012454423,-0.04636518,-0.059376594,-0.00082406774,-0.042358257,-0.087978564,-0.008541488,0.01590677,-0.06452263,0.0008737103,-0.05033378,0.046145674,0.0022433065,0.11927876,0.060828492 +1.14.13.73,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.14.13.74,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.14.13.75,A heme-thiolate protein (P-450). Forms a stage in the biosynthesis of the indole alkaloid ajmaline.,384,0.99999994,-0.05043048,0.0067420024,0.0005561721,-0.011705122,-0.021844048,0.08566293,-0.011688013,0.06208063,0.051812932,-0.021272287,-0.008193681,-0.030811932,-0.03679121,0.007120134,-0.009975382,0.039956663,-0.016721567,0.05907352,-0.059691153,-0.118583016,-0.003412147,0.08308159,0.048232257,-0.039408796,0.012578637,0.034654513,0.059118748,0.010719716,-0.021675443,-0.041733563,0.012832189,-0.049657594,0.021631135,-0.010936391,-0.034788996,0.041717708,-0.11008755,-0.024916913,0.10053417,0.007986385,0.060191087,-0.03001397,-0.12993257,0.038173307,-0.056078672,-0.03418745,0.0017137913,0.015518184,0.0016040072,0.023456005,0.006167887,-0.011211826,-0.053706735,0.051667638,-0.048114177,-0.090065576,0.011060425,0.09088878,-0.029000828,0.008165844,0.028183687,0.076185666,-0.020537792,0.011942287,-0.031754855,-0.07941287,0.027274199,0.0019784144,0.038925562,-0.041827116,0.00106296,-0.052258834,0.006654288,0.053845797,-0.053102117,0.07924799,-0.022145469,-0.017148731,-0.06364959,-0.041685075,0.07000225,0.05782675,0.014958301,0.10191743,-0.03283396,0.00420627,0.018535927,0.07764174,-0.00938867,-0.03213817,0.039192885,0.021354116,-0.045512907,-0.036177848,-0.03391649,0.06668128,0.044272378,0.020474458,-0.022441879,-0.009129021,0.04846487,0.033245694,-0.040290814,-0.0307609,-0.04225784,-0.03852877,-0.047503576,-0.012816808,-0.0037627527,-0.059161797,0.0123832235,-0.06646999,0.05605717,0.006889952,-0.016858798,0.08229599,-0.06642271,0.00047293984,0.013014259,-0.035014436,-0.05401571,0.00021197468,0.02173184,0.07641705,-0.056384757,-0.017419316,-0.092204764,-4.2164486e-34,0.07399672,0.014468421,-8.580585e-05,-0.0022185494,-0.01789718,-0.07928074,-0.09613111,0.04045683,-0.026228953,-0.0009655297,-0.06301372,-0.097759,0.06272861,-0.08227655,0.0070321457,-0.04913126,-0.1179744,0.028713893,0.0381529,-0.029498532,-0.13095911,0.030621717,-0.042779144,0.07127708,-0.072265066,0.08464314,0.052048363,-0.019882899,0.004846999,-0.006726866,-0.053947847,-0.016691007,-0.036168728,-0.029937685,-0.032635044,-0.009218309,0.037802104,0.020924129,-0.077068515,0.010402156,0.019778898,0.04353805,0.0336221,0.045328036,0.048042025,-0.021770477,-0.118729174,0.08160576,0.018803915,0.03954456,0.0051604295,-0.026547113,0.1852684,0.03609326,-0.057823267,0.023215966,-0.023953902,0.02051646,0.0045666336,0.0803199,0.05667776,-0.0072151204,-0.024559233,0.072935104,-0.013443668,0.038090896,-0.065038204,-0.111881904,0.04176785,0.10849652,-0.03161933,0.026693359,0.077051684,0.014860156,0.028672952,0.0074392287,0.0488632,0.050280653,-0.00078426884,0.023048779,-0.0023396045,-0.01096325,0.0027620571,0.0052273776,0.03743283,-0.043863554,0.0027887342,-0.0010685012,0.005446269,0.06672919,0.058007203,0.008736597,-0.09853767,0.054115,-0.009663248,2.9983977e-34,0.08795826,-0.07818093,-0.030442799,-0.044613034,-0.056019798,0.05479447,-0.03408912,0.048350096,-0.03399438,0.054553356,0.10324844,-0.023866352,0.07203609,0.009132739,-0.021766465,-0.09001908,-0.014879513,0.046004757,-0.014017862,0.13008837,-0.045635518,0.04741585,-0.025111545,0.015920043,0.041722257,0.039829236,-0.044447992,0.038163852,-0.028734973,0.059344374,0.06377538,-0.0080742445,-0.10322954,-0.04065152,-0.01074274,0.04478372,0.06673516,0.01939303,-0.004218818,0.06567606,-0.063137785,0.06638345,0.033968408,0.04916645,0.07839199,0.0636462,0.009154681,0.02349167,-0.059296925,-0.11443402,0.021205492,0.00078275835,0.008434009,-0.014484268,-0.01201296,0.01563496,-0.008387184,0.015157849,0.0013929907,-0.03644096,-0.015363359,-0.0331941,0.078102306,-0.010801296,-0.04332844,0.046487417,-0.020779582,0.06204418,0.07846593,-0.041820567,0.020559212,-0.03143168,0.028717147,0.061357517,0.057382643,-0.05720826,0.024412505,-0.023186576,0.0412032,-0.0025231834,-0.003893222,0.09214594,-0.04233183,-0.111422114,0.034614727,0.020855159,-0.028469626,0.15394236,0.032606617,-0.0015149981,0.0025963152,0.015983643,-0.09822246,0.11547709,0.046784233,-2.603022e-08,-0.008452939,-0.0789432,0.011042347,0.026098335,0.0099481465,0.045768972,0.04022967,0.005545799,0.039620794,-0.062871374,-0.009270703,0.00688571,-0.07307094,0.054947164,-0.005764169,-0.019763183,0.00672195,0.09865325,0.015106794,-0.02278746,-0.043523848,0.02527935,0.025743356,-0.021749418,0.018375479,-0.07765787,-0.022002345,-0.05446004,0.025872529,-0.040568233,0.016751429,0.067646936,-0.029749973,-0.049279187,0.020626284,0.021147957,-0.019681523,0.022788743,0.012588384,-0.015856326,-0.03244667,-0.07765451,-0.0906564,-0.024110151,0.047642212,-0.011241198,0.039395798,0.04090494,-0.024278047,-0.098792836,-0.00694771,0.0007556803,0.026215257,-0.10205496,-0.106183246,-0.07046985,-0.014911603,-0.061010405,-0.0496148,-0.11563033,-0.0045345635,-0.010913427,0.13543986,-0.044375792 +1.14.13.76,This microsomal cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).,384,1.0,-0.0017058429,-0.002803414,-0.018778205,-0.030963717,-0.027598394,-0.0126019465,0.036727313,0.077030145,0.049914815,0.036959004,-0.0035799008,0.05774946,0.012115137,-0.029696438,-0.022665283,0.029476747,-0.036393866,0.008281658,0.009553897,0.02887761,0.06881654,-0.02874217,0.04703949,0.03837667,-0.060569666,-0.0074806474,0.0024336502,0.0890766,-0.036092717,-0.049403302,0.056186654,0.053679276,-0.02583472,-0.025403138,0.03866223,0.044997804,-0.08508672,0.03102957,0.024674602,0.013820654,0.07404329,-0.046074003,-0.07384023,0.046556413,-0.04356538,-0.16316663,-0.103413545,-0.01385487,0.098745026,0.070960835,-0.029532291,-0.028393682,-0.03999072,0.022148838,0.0363067,-0.026483342,0.041022573,-0.02704255,-0.032961227,-0.039911788,-0.036983795,0.022330826,-0.020203147,0.01718619,-0.04745517,0.066363655,-0.021414476,-0.053772494,-0.00496888,-0.04603718,-0.10567921,-0.07236368,-0.00094208494,0.005010609,-0.08701604,-0.002562303,0.030274851,0.032885674,0.0062976163,-0.05359091,0.062097996,0.031639673,0.004033515,0.06775354,0.053532742,0.028617928,0.081478454,0.028890928,0.07733894,0.00080369035,-0.024994558,0.09056274,0.004279111,-0.0100692585,-0.07094414,-0.019169409,0.025035495,-0.03190019,-0.06133139,0.010748064,0.10161109,0.005510315,-0.048883043,-0.09865835,-0.048774853,-0.0011253711,-0.04337156,0.0025643327,-0.02968657,-0.06867066,-0.02176055,-0.010271287,-0.023735404,0.05169494,-0.019535702,0.07850291,-0.00861249,-0.07195488,-0.018231763,-0.075402826,-0.04565807,-0.059727225,-0.021226095,-0.017604709,-0.02997062,-0.018368872,0.045941062,5.5685366e-35,0.024006441,-0.0057436507,0.028214863,0.018947013,0.039477233,0.024648834,-0.032100324,0.02564644,-0.13551632,-0.06202059,-0.09556926,-0.06049858,-0.054164052,0.034174554,0.013078889,-0.037587464,-0.0030889509,0.030787982,0.06511894,-0.018791271,-0.04800475,0.02777784,-0.042850994,-0.083244614,-0.047450125,0.12811661,-0.08626043,0.007918869,0.012481017,0.003974122,-0.061555948,-0.038593143,0.013068148,0.007561374,-0.019692352,0.021081224,-0.02907276,-0.002685633,-0.040832818,0.050717067,-0.046889953,-0.040715378,0.06369527,-0.009218483,-0.004777326,-0.008695371,-0.04051826,0.02233791,0.026859937,0.0027062304,0.023116838,-0.0004162282,0.063497975,0.042542655,-0.11099338,0.05009241,-0.040322192,0.00060376775,-0.05639222,0.041773632,0.084292956,0.018040372,-0.030244177,0.064240806,0.015787194,0.0637248,-0.0019547339,-0.04685753,0.044405792,0.13340648,-0.057439808,0.019047849,0.124203056,0.041553486,0.07784723,0.045859553,0.025898801,0.08388835,-0.016085975,0.09072756,-0.043600634,-0.036630675,-0.042253524,-0.024807122,-0.04747038,-0.00486489,0.028470902,0.031313434,-0.023944577,0.03143792,0.038808394,-0.10061675,-0.01876093,0.0338985,-0.0012585138,-3.0486705e-33,0.029432734,-0.09534955,0.07422226,-0.089485645,-0.07358015,0.11025398,-0.0043503996,-0.046670668,-0.004945424,0.09452003,0.026840737,0.008920823,0.041156627,-0.054591443,-0.029064564,-0.02746894,0.028506953,0.035332195,-0.034982216,-0.011929035,0.060919043,0.09648835,0.0067698425,0.10266035,-0.040014155,-0.01815871,0.07656587,-0.005294084,-0.0034477578,0.021853104,0.0023881956,0.0782479,-0.039079797,-0.0071815224,-0.0035166244,0.011438541,-0.046054877,0.0027484691,-0.016125172,0.04222359,-0.11959005,0.035872493,-0.027911734,-0.010965121,0.059039447,0.01205825,-0.104627475,-0.004576059,0.022383906,-0.0017861596,0.0401733,0.07520828,-0.013565524,-0.0050637545,0.015161003,0.052479774,-0.049823776,-0.03208518,0.08328332,-0.0143787265,-0.04313242,-0.011160686,-0.014511484,0.0090886075,-0.00070698076,0.041548494,0.0063771387,-0.030570302,0.09059182,-0.002253194,0.04249698,0.050869767,-0.027706621,0.09687566,-0.028220087,0.060746055,0.011437619,-0.09931979,0.03056468,0.010114589,0.032799046,-0.017569825,-0.010405783,-0.040277377,-0.13785125,-0.08844288,0.012729009,0.019902429,0.019136278,-0.0140749635,0.043288387,0.00926138,-0.0762717,0.029629119,-0.0048976587,-2.7766053e-08,0.03325878,0.00954157,-0.007985256,0.037029408,-0.041488733,-0.0135620255,-0.016657831,-0.040076673,0.07787144,-0.047954597,0.024050245,0.041018717,-0.018079557,0.045687586,-0.02939596,0.06824011,0.028827682,0.012628586,0.016309395,0.009438549,-0.081240684,-0.03486292,-0.052444015,0.01686047,0.046930715,-0.1331469,0.0047397856,0.070738904,0.018206807,0.027627915,-0.0031527157,0.0014865772,-0.120814614,0.0020685187,-0.033933844,0.07584414,-0.03287939,-0.051077764,0.046410657,0.05626525,0.040791746,-0.140184,-0.025021095,-0.013226011,-0.039542962,0.024161272,0.020458968,-0.07188126,0.016571058,-0.008223615,0.00485151,0.054205004,-0.0044138925,-0.11146184,-0.09621623,0.008710258,-0.011123443,-0.034763314,-0.044897676,-0.12519307,0.024672909,0.006693254,0.20156771,0.0019864887 +1.14.13.77,This cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).,384,1.0,-0.0044295248,-0.0023768498,-0.018777901,-0.033765774,-0.02915995,-0.0032450736,0.017848719,0.06933085,0.05369936,0.025026077,-0.007078088,0.06007883,0.014181892,-0.038373996,-0.03055552,0.030284006,-0.029794492,0.0010467956,0.010185534,0.025581505,0.072005354,-0.03706825,0.049926177,0.048881058,-0.046449233,0.004432401,-0.0041636666,0.0855726,-0.039273903,-0.056008276,0.04015716,0.03125708,-0.03372042,-0.021950824,0.026719794,0.03927472,-0.080897875,0.025808789,0.034568172,0.021471271,0.06422429,-0.04506244,-0.07296139,0.04055138,-0.03396728,-0.15045533,-0.10040361,-0.01854544,0.100092,0.06655796,-0.01647225,-0.022194037,-0.041626967,0.01798037,0.040251855,-0.019293698,0.03850228,-0.025515106,-0.03653324,-0.036006488,-0.029989244,0.030142719,-0.020175051,0.018573094,-0.051106434,0.053475488,-0.020086732,-0.035687864,-0.008547705,-0.044307116,-0.11689884,-0.07628633,-0.0033676801,-0.001967204,-0.08834453,0.007544202,0.035001863,0.035163566,0.0039344016,-0.074577264,0.09767898,0.02366373,0.012458601,0.07916221,0.056080837,0.022097828,0.07158258,0.028618192,0.08522507,0.007594455,-0.015991578,0.074417576,0.012252974,-0.008361934,-0.07826909,-0.002128259,0.025538994,-0.02575275,-0.066398054,0.01929809,0.096051276,0.004568012,-0.054200854,-0.10512317,-0.046876505,-0.00010360909,-0.035855625,-0.0007600101,-0.03273789,-0.073237926,-0.0236561,-0.018627862,-0.02901327,0.041266195,-0.03284102,0.08619073,-0.017828815,-0.06980286,-0.015319076,-0.082713835,-0.03484015,-0.06540337,-0.0051111565,-0.010280361,-0.024592971,-0.012396353,0.031806566,-3.3884593e-36,0.0314333,-9.875714e-05,0.026672099,0.010779844,0.03684901,0.014144838,-0.03467846,0.031259432,-0.13501354,-0.06620253,-0.10161761,-0.061092455,-0.059299964,0.028826917,0.011371241,-0.029290777,-0.012467824,0.03446276,0.07046251,-0.014120475,-0.038623113,0.027820282,-0.04452273,-0.07941255,-0.036970116,0.13184312,-0.08444374,0.0073136217,0.011069448,0.0055131074,-0.05707897,-0.03659223,0.008104869,0.0017044338,-0.006169924,0.014208714,-0.025775842,-0.0023708139,-0.04081538,0.05731383,-0.051167592,-0.04244341,0.06345238,-0.015995272,0.0056646164,-0.003056155,-0.04485085,0.021539006,0.03642612,0.025557507,0.0119165955,-0.0035360823,0.060557067,0.04555636,-0.10780694,0.038265113,-0.03481127,0.011181052,-0.04856977,0.04062275,0.073212564,0.031847525,-0.03959549,0.052149992,0.011301643,0.07139876,-0.013563032,-0.063317254,0.05176227,0.1384238,-0.07142681,0.014794062,0.10687951,0.037743594,0.08368361,0.040018953,0.013804496,0.075406924,0.0007488648,0.09279909,-0.05498208,-0.030621633,-0.023319429,-0.016776301,-0.05046868,-0.009078418,0.02946108,0.025504623,-0.024029946,0.031401668,0.047318086,-0.092667095,-0.023239082,0.03629824,0.0006585871,-2.617718e-33,0.03306688,-0.07605978,0.076612614,-0.08317264,-0.075777896,0.1138612,-0.006674306,-0.06748866,0.0043547717,0.091880724,0.03581117,0.008779366,0.036114354,-0.041901454,-0.036204018,-0.03955289,0.017617572,0.03445271,-0.059657756,-0.011933774,0.050545283,0.1018272,0.015079602,0.09315785,-0.031001933,-0.01393569,0.08286909,-0.0024811453,0.006838994,0.022071144,0.0042415136,0.06768408,-0.035315298,-0.008799367,-0.011154113,0.02684063,-0.044272654,0.008608361,-0.017775534,0.0551757,-0.11156886,0.03540922,-0.026347013,-0.009949018,0.06484426,0.014031938,-0.11312039,0.0008892632,0.0368486,-0.005412084,0.06845664,0.06757541,-0.0059201517,0.009961559,0.024757838,0.04935082,-0.04239498,-0.027627207,0.059147,-0.018064136,-0.045014963,-0.008297146,-0.0070062797,0.002515965,0.0116177285,0.028631737,0.0008148457,-0.028998286,0.09577367,-0.004801335,0.038022365,0.03613748,-0.027542897,0.099950485,-0.014867714,0.05738601,0.013077991,-0.10549185,0.027405033,0.014642238,0.023493603,-0.018896008,-0.006926659,-0.041147526,-0.14565775,-0.07944889,0.011718548,0.019641297,0.03243385,-0.013730857,0.046916608,0.017844139,-0.07197981,0.0416777,-0.010283776,-2.6880729e-08,0.032263365,-0.001220788,0.0039476724,0.040940087,-0.033303667,-0.01366106,-0.017994057,-0.04297079,0.074019164,-0.05083483,0.021250708,0.054178525,-0.018280398,0.040715814,-0.02236857,0.067887716,0.026621934,0.015269789,0.0128908865,0.019718718,-0.072920874,-0.03944967,-0.06618117,0.0065562367,0.049040124,-0.14191468,-0.0033796616,0.0608046,0.02074544,0.036555715,-0.00400885,-0.011909146,-0.113419324,-0.014235751,-0.030226337,0.08582273,-0.024048375,-0.06847355,0.04274484,0.06700189,0.04313348,-0.12880777,-0.028049493,-0.00895511,-0.028216323,0.017639693,0.016893907,-0.08399072,0.0089011565,-0.02090054,0.0019970017,0.047153562,-0.0034832773,-0.11353341,-0.09726487,0.009892846,-0.0074648005,-0.03503114,-0.044840794,-0.1263482,0.023514513,0.005333536,0.21239144,0.016015785 +1.14.13.78,Requires cytochrome P-450. Catalyses three sucessive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid.,384,1.0,-0.0956156,-0.007949614,0.01605122,-0.02476627,0.07628488,0.05607033,-0.080083475,-0.008970637,0.0053066476,0.024818867,-0.0040860455,-0.040442616,-0.037272032,-0.0023494628,-0.031163314,0.074576594,-0.092064515,-0.017053012,0.015309963,-0.028056378,0.016717013,-0.0719563,0.04868304,-0.0037843683,0.019597445,0.06510618,-0.0013246393,-0.034838285,-0.044577967,-0.056660246,-0.0489172,0.020998979,-0.041261885,-0.025989272,-0.037507344,0.06427492,-0.14236067,0.044165608,0.051070508,-0.017093351,0.004263732,-0.017442113,-0.11463955,0.019201854,-0.02494976,-0.034952726,-0.059420608,0.00037871153,-0.006727378,-0.0011366124,0.016814964,0.012593099,-0.030561475,-0.040401198,-0.009233644,-0.027405486,-0.078037955,0.038749926,0.01259071,0.054613665,0.121025056,0.016753882,-0.050859638,0.011202496,0.009886413,-0.05763597,0.01882605,0.011306591,-0.013892806,-0.005803628,0.0129356515,-0.069738075,-0.06455991,0.0074634016,-0.022122318,0.052381646,-0.0014220864,-0.060335815,-0.051106025,-0.005653806,0.08338343,0.011601878,0.0047653685,0.028919568,0.09436281,0.020255858,-0.047901917,0.0015207164,-0.040509626,0.04732823,0.0036053334,0.01623592,-0.013485153,-0.013279678,0.06432938,0.04428115,-0.027972577,0.065681815,-0.05024231,-0.030940231,0.027205141,0.11657166,-0.070138924,-0.0691393,-0.0060697924,-0.06944083,0.03381676,0.004916169,0.0008198151,-0.07582878,-0.034353767,-0.093097866,0.0130380755,-0.059141643,0.008210105,0.06338437,0.042758644,-0.035292413,-0.03887212,0.013308401,0.0047341436,-0.0041539385,-0.024339091,-0.0020265018,-0.0860609,0.017097488,0.02231304,2.8608645e-33,0.070765674,0.06476942,0.005282115,0.031883072,-0.021285992,0.0054198354,-0.096302055,0.019335113,-0.087169856,-0.032463253,-0.070113964,-0.08491611,0.040265325,-0.025825405,-0.045633063,0.06237848,-0.037187982,-0.0075607705,0.108099654,-0.039322086,0.009233257,-0.010909986,-0.06931711,0.00802614,-0.069030605,0.06471696,0.0035442556,-0.050320286,0.0023782772,-0.027454665,0.03976419,-0.015282381,-0.07196437,-0.0057890615,-0.08442078,0.009492023,-0.01389702,0.0043543754,-0.039340578,0.06376159,-0.052800883,0.011729713,0.049490362,-0.028640144,-0.03792041,0.031048242,-0.076081045,0.055383775,0.007151559,0.067628324,0.064811036,0.018788612,0.0553792,0.07613088,-0.040772416,0.061335977,0.04345255,-0.0798858,-0.013671077,0.015894348,0.09463972,0.010493533,0.009862323,0.038335696,0.051114064,0.0020522026,-0.06424755,0.019767845,-0.031266063,0.09685417,-0.08784634,-0.010952706,0.09636075,-0.0708609,0.039272778,0.06528069,-0.033916485,0.061761945,-0.06349583,0.09833685,0.0036630481,-0.02363414,0.039913215,0.014950347,0.027411161,-0.022708688,0.0048968983,0.019176358,0.09103005,0.07554932,-0.002174568,-0.1235194,0.0080871545,0.008014395,-0.056770224,-3.590261e-33,0.14446922,-0.05936429,0.028548602,-0.037347987,-0.03427743,0.05990283,0.01237722,-0.07773541,-0.010596367,0.047016542,0.13019481,-0.028167441,0.036880057,0.028095646,0.076193176,0.0036505782,-0.011098859,0.03274464,0.038806435,-0.0043311426,0.04120609,0.08239825,-0.024799345,0.08160474,0.03285246,0.05989828,0.022963107,-0.07910665,0.041935947,0.034021676,-0.058130626,-0.06741474,-0.016862743,0.021996884,-0.0040764827,0.08524695,0.013089656,0.05499102,-0.0642955,0.10319015,-0.01608061,0.11614992,-0.02839511,0.051146295,0.028855382,0.009225931,-0.037272118,-0.07255273,0.011635461,-0.06601166,0.13361308,0.045982968,-0.050538685,-0.038598098,0.043106604,0.09235399,-0.043857045,0.038130146,-0.05104703,-0.023678498,-0.008033914,-0.05592043,0.03258838,-0.08370687,-0.05108706,0.033263735,-0.012374195,0.092303686,-0.015893565,-0.070919625,-0.08575707,0.017094163,0.09492093,0.07608661,0.03190877,-0.020784782,0.0043422026,0.02949625,0.061985318,0.019299062,-0.006411505,-0.04980431,-0.04077782,-0.033766985,-0.018515974,-0.083817735,-0.031798974,0.045244407,0.082778856,-0.091369264,-0.028649539,0.06624326,0.03518722,0.093675494,0.038199756,-2.762113e-08,0.079602115,-0.042374823,0.062343508,0.02724626,-0.03932841,-0.009429602,0.007939189,-0.0029864556,0.022223076,-0.121277764,0.0073746806,0.03417551,0.022206228,0.0053703166,0.07115667,-0.029078638,-0.06962697,0.011696704,0.023469342,-0.017568873,-0.1263327,0.024977703,-0.049641654,-0.000983757,0.04991526,-0.01699693,0.0003034284,-0.032470085,0.01740989,0.03918369,0.02177661,-0.005014929,-0.06912036,0.017580822,0.040781107,-0.012083514,-0.025397092,-0.05262483,-0.01736244,0.025431255,-0.09606135,-0.08482393,-0.074095264,0.026003271,-0.054644022,-0.020292683,-0.008126511,0.02143337,-0.025848616,0.01323677,-0.057824153,0.0333595,0.020372078,0.015281633,-0.01966043,0.02986365,0.054990135,-0.07233975,-0.023905283,-0.10804723,0.0065260236,0.01383331,0.11854309,-0.02729869 +1.14.13.79,"Requires cytochrome P-450. Catalyses three sucessive oxidations of ent-kaurenoic acid. The second step includes a ring-B contraction giving the gibbane skeleton. In pumpkin (Cucurbita maxima) ent-6alpha,7alpha-dihydroxykaur-16-en-19-oate is also formed.",384,1.0,-0.07665393,-0.022681851,-0.023637822,-0.022459105,0.012448518,0.03392038,-0.04833361,-0.029576773,0.020780707,0.044210363,0.006146797,-0.04271346,-0.021375,-0.039575726,-0.01378875,0.07060937,-0.053010054,0.041587964,0.012193059,-0.0118657,-0.03591376,-0.051973384,0.03920324,0.016655663,0.065312795,0.031184638,-0.013677739,-0.018080162,-0.063811295,-0.14633878,0.026397828,0.034496076,0.005264888,0.012556979,-0.028171118,0.06556882,-0.111502126,-0.0008083149,0.07245529,-0.045107022,0.02121965,-0.03828941,-0.05098503,-0.013714868,0.027423894,-0.028002333,-0.059272338,0.01574406,0.017762063,-0.044775367,0.012967258,-0.04737963,-0.073597,0.039559223,0.014618186,-0.02126346,-0.021128736,-0.026725678,0.042130005,0.018320909,0.07611999,0.01773844,-0.052063268,0.030024089,-0.007832501,-0.09132281,-0.0025940519,-0.044275973,-0.033769235,-0.025802823,0.046113137,-0.064086854,-0.088448256,-0.05513124,-0.06284254,0.080416165,-0.020088498,-0.021528637,-0.036693048,-0.0027695857,0.05960496,0.05356691,0.066763304,0.07161482,0.06340645,0.051598586,-0.053820953,0.049815204,-0.0441119,0.05381521,0.026779868,0.035637286,0.0017936917,0.021356968,0.03542389,0.0062575024,-0.02389866,0.042442583,-0.024686523,-0.00017518798,0.021285746,0.081058085,-0.025736371,-0.067039154,-0.0362102,-0.026288727,0.017681446,0.051520325,0.038810946,-0.05575437,-0.0069862655,-0.12699063,0.026328273,-0.045508515,0.010088679,0.0978493,0.050683405,-0.0044829887,-0.0049926457,-0.025569938,0.020982534,-0.033041954,-0.00768685,0.016628798,-0.16497646,0.044454217,-0.017679682,5.210167e-33,0.10936148,0.037053484,0.026001383,-0.002038883,0.027747938,0.039074153,-0.12562284,-0.029430358,-0.07822591,-0.047353014,-0.11413901,-0.004049555,-0.00072080846,-0.0042538657,-0.004982255,0.06181149,-0.07456264,0.0068450253,0.06040332,-0.043924484,-0.015060277,0.008972786,-0.10399742,0.007391479,-0.016436066,0.055974558,0.0003131311,-0.0574128,0.002593073,-0.025677653,0.067546405,-0.014732185,-0.06756672,0.013076626,-0.07835622,-0.020536829,-0.028014658,0.016850825,-0.064547375,0.05465045,0.023335243,-0.026004316,0.005281756,-0.03576483,0.019121258,-0.013354445,-0.007641201,0.11189507,0.06591614,0.08561081,0.08674285,0.03968869,0.03128101,0.05746014,-0.070073076,0.0756643,0.055333078,-0.020056989,0.05440595,0.06431991,0.0700541,-0.011244703,0.0147610465,-0.029505465,-0.0057930886,0.035638176,-0.07397077,0.060552392,-0.07608772,0.045603603,-0.07725863,-0.010634915,0.077096574,-0.058260337,0.014562969,0.0141414115,0.0071439287,0.031381648,-0.036070373,0.033568442,0.022159265,0.013234035,0.014636804,0.0048267734,-0.004952765,0.0066073094,-0.007216391,0.025426557,0.028430808,0.092760555,-0.0036507677,-0.052382875,-0.050815146,0.021056717,-0.023748502,-4.2063475e-33,0.11938612,-0.122987315,0.0074419845,-0.046614904,-0.019737516,0.0012732174,0.0012037109,-0.0916166,0.046086054,-0.00035845634,0.06139536,-0.009819579,0.058668315,-0.013574093,0.077501066,-0.04205941,-0.014951231,0.1157162,-0.009227304,-0.006962082,0.009119411,0.07759866,-0.049299743,0.046520233,0.033500783,0.08410667,0.04525703,-0.042546984,0.07609079,0.03786204,-0.05161372,-0.027134623,-0.021588009,0.051754136,-0.059296463,0.07375102,-0.03810276,0.028651457,-0.029753951,0.096369505,-0.050699353,0.094579935,0.011151082,0.058214862,0.07727771,0.0076099657,-0.056084234,0.0020705175,-0.002359099,0.012426273,0.15305486,0.024943328,-0.045175713,0.02390671,0.03530648,0.058803365,-0.03044518,0.04136396,-0.01559756,-0.082772866,-0.011870272,-0.038033098,0.05831988,-0.037837736,-0.011369979,0.052835025,-0.017740339,0.11692743,-0.028297693,-0.055172257,-0.071201816,-0.005141329,0.009599785,0.027463464,0.046313316,-0.017424004,-0.007220109,0.009473341,0.05330057,0.002338441,-0.054502178,-0.0020278997,-0.025606798,-0.042696185,-0.010566161,-0.05519132,-0.015562405,0.07950231,0.079585776,-0.022073383,-0.046172436,0.06346716,0.027348172,0.10768801,0.055723593,-3.881297e-08,0.057857636,-0.06343577,0.05691818,0.028405286,0.0055441423,-0.035414938,0.08994578,0.016396256,-0.020198837,-0.12938173,0.015346754,0.092830576,0.026783362,0.0011274288,0.0369304,0.016097525,0.004846085,-0.00060888985,-0.010277495,-0.041282754,-0.11421893,0.027758,0.026098464,0.03384329,-0.035719234,-0.043777145,0.012045205,0.0077725244,0.012395848,0.04552545,0.0063261325,-0.0051297112,-0.06596564,-0.09093534,0.001384357,0.012285762,-0.006377989,-0.084786616,0.011847382,-0.00082637434,-0.10175677,-0.12262483,-0.018075429,-0.012122697,-0.08412139,-0.027526487,-0.0042566466,0.021078171,-0.0480945,0.058115385,-0.039334446,0.02532369,-0.008117871,-0.031883128,-0.097235374,0.06619243,0.04332136,-0.038884718,0.019789606,-0.07648847,-0.0067108893,-0.013529027,0.17970107,-0.040891152 +1.14.13.80,"The reaction is stereospecific with over 95% yield of (+)-trans-carveol from (R)-limonene. (S)-Limonene, the substrate for EC 1.14.13.48, (S)-limonene 6-monooxygenase, is not a substrate. Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds.",384,1.0,-0.08066461,0.015589484,-0.0949427,-0.027223319,0.034093376,0.07178369,-0.111314006,0.009324794,0.03581804,-0.01697557,0.03755527,-0.113516256,-0.09349864,-0.05366508,-0.046214495,-0.037348814,-0.044422757,0.018174699,-0.012073277,-0.015144867,0.017496325,0.0044966927,0.004051764,0.036269385,0.0066964324,0.00908905,0.026698407,0.011199368,0.018764284,-0.022141302,0.02318836,0.03062611,0.07408382,-0.022022348,-0.0707109,0.016057076,0.01005882,-0.06887101,0.107589036,-0.011706334,0.021186588,-0.06145246,-0.055484813,-0.10755818,0.030430011,-0.095696576,0.017569322,-0.005308264,0.058441404,-0.09639655,0.04113804,-0.0389505,-0.022347283,-0.06552853,0.020647224,0.035915624,0.0014142098,0.004691254,0.01122524,0.033892173,0.048386343,-0.0104061,-0.073956735,0.05708217,-0.11542261,-0.029654263,-0.011633955,0.021748418,0.026145918,-0.0008675566,0.0031152945,-0.10694549,-0.012550704,-0.026532976,-0.011032434,0.1375647,0.054893207,-0.06425604,0.04204059,-0.048611615,0.032305382,0.004327894,0.014600388,0.0053248205,-0.03530134,-0.017286144,0.026157973,-0.029244272,0.07282516,0.06883162,0.028903112,-0.01905332,0.010930364,-0.01873783,-0.0036932707,0.026539912,0.1048171,-0.04080511,0.050597787,-0.03148263,-0.011140556,0.115302,-0.03768307,-0.0636283,-0.05063942,0.074892946,-0.03103986,0.11379818,0.021065582,-0.050398063,0.026268017,-0.043196224,0.06382773,-0.022560688,-0.075742155,0.07200732,-0.004432848,-0.035946805,-0.031275447,0.030027812,-0.014042894,0.00037768044,-0.007359661,0.006726952,-0.007886147,-0.013609379,-0.01932414,-8.182923e-34,-0.0014945208,0.045812592,0.014263705,-0.026302056,0.09898162,-0.0063074464,-0.10389796,0.014100189,-0.029517028,-0.06476425,-0.108148515,-0.034704674,-0.03420324,0.009758053,-0.03716711,0.032482795,-0.048242953,0.014981508,-0.019071793,-0.02260396,-0.06970414,-0.032093532,-0.07145397,-0.025807777,0.016608026,0.03324386,0.022880241,-0.03859921,0.0043782047,-0.009075863,-0.067094564,-0.014428093,-0.003552834,0.02569141,-0.0068940767,0.0064975834,-0.019914886,-0.033786163,-0.035027564,0.03319925,0.06356719,0.042686973,-0.019163333,-0.02430648,-0.006873362,-0.05400525,-0.020666923,0.08535571,0.09214783,0.12976876,0.04696605,-0.013801315,0.05870443,-0.008825964,-0.020836787,0.11882605,-0.066682726,0.048983864,0.0921214,0.009775549,0.02929298,0.09144405,0.029772252,0.020847302,0.0575799,0.080317624,-0.15219344,-0.04141393,-0.058765363,0.06032983,0.0047242083,0.02621494,0.011323379,0.0038674732,0.10123133,0.020632738,-0.0016954552,0.0142569225,0.0165307,0.024289306,-0.06615417,0.06803066,0.027681658,-0.04345841,-0.029558452,0.04521478,-0.06534616,-0.017281635,0.00579057,0.09287192,0.024910795,-0.094915695,-0.03942963,0.0044476953,-0.026185472,-1.0818337e-33,0.04686738,-0.053997956,0.031807587,-0.07621801,0.000105876454,0.071836784,0.012784012,-0.05294158,-0.018305501,0.005069028,0.029620191,0.06981553,0.08261421,-0.020719428,-0.026723783,-0.021253439,0.059549637,0.052825026,-0.064068966,-0.01063901,0.01508579,0.035116583,-0.021576645,0.07008224,0.0641687,-0.05338532,-0.030189205,0.04193252,0.033076156,0.019286083,0.114617005,-0.026804062,-0.0077756178,0.059943374,0.04061884,0.15340948,0.013481357,0.037757877,0.025311735,0.07007604,-0.08887189,-0.058805566,-0.03355194,0.045664202,0.06926182,0.015695272,-0.030077562,-0.04720836,-0.01146996,-0.03215581,0.010632839,0.070596665,-0.0569661,0.04479366,0.03329241,0.03282077,0.04313058,0.0038390367,0.0015624737,-0.06237948,0.008892353,-0.032831583,-0.026908651,-0.050997555,0.04415022,-0.0057353424,-0.04465584,0.032869574,0.041261468,-0.082628265,0.15764824,0.020845149,0.0069506774,0.03697431,-0.050879594,-0.047076996,0.019929659,-0.07254869,0.0057298546,-0.03002514,0.054654293,-0.033335797,0.06414722,-0.001495954,-0.0969825,-0.046151266,0.02832947,0.016162232,-0.004740484,0.06315536,0.010302056,0.009485769,-0.074911036,0.06533779,0.10290585,-3.730035e-08,0.066899836,-0.08095252,0.056070425,-0.016602522,-0.047629848,0.056864083,0.009917781,-0.013713018,-0.041060317,-0.071937576,-0.042040598,-0.030856801,0.011393768,0.001156729,0.00964015,-0.0008501274,-0.023049137,0.044225235,-0.040813327,-0.0004111559,-0.07260294,0.009111529,-0.08961219,-0.047371008,-0.0061987815,-0.15626843,0.017467113,0.028847337,-0.0043972544,-0.083598785,0.02536537,0.03469877,-0.067732014,0.054943837,-0.020185538,-0.009543261,-0.026121581,0.03408147,-0.006643969,0.0017549404,-0.013460986,-0.07195583,-0.050757386,-0.014515425,-0.03247079,0.09496294,-0.0015683235,0.051255595,-0.028549174,0.033623315,0.07850864,-0.012890552,0.059786595,-0.026093438,-0.04707112,-0.0150253,-0.027807014,0.00059127633,0.0038030776,-0.021525215,-0.055457003,0.07441374,0.1510987,-0.022105746 +1.14.13.81,"Requires iron(II) for activity. The enzyme participates in the biosynthesis of chlorophyllide a in aerobic organisms. The same transformation is achieved in anaerobic organisms by EC 1.21.98.3, anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase. Some facultative phototrophic bacteria, such as Rubrivivax gelatinosus, possess both enzymes.",384,0.99999994,-0.093734264,0.010340472,-0.091034204,0.040445656,0.08274462,0.010585527,0.010313131,-0.024190025,0.004493187,-0.019499803,-0.020771747,-0.073604405,0.011239661,0.037049364,0.0012433002,-0.0036389956,-0.08503321,0.043358877,-0.06648688,0.0170698,0.076825775,-0.011815048,-0.034299918,-0.001599075,-0.026194774,-0.02769968,0.013980062,-0.008801168,-0.05149703,-0.025429834,-0.025106244,0.059172973,0.10913445,-0.08515006,0.06646336,0.118275195,-0.004599931,-0.09414731,0.044046465,0.0042413166,-0.019882778,-0.00086997304,0.0011637111,-0.045806643,-0.008591569,-0.0032179684,0.09893669,-0.0036128936,0.033105213,-0.013720472,-0.06372936,-0.012027347,-0.047571413,-0.020303816,-0.043268304,-0.037852813,-0.028685829,-0.07120011,-0.007949865,-0.046829283,0.031579748,-0.045002125,-0.041670654,0.027439406,-0.023068458,-0.07239585,0.029538317,-0.07126178,0.023036031,-0.052022498,-0.06159067,-0.03881066,-0.088804945,0.0028094847,-0.076692194,0.043889098,0.102748685,-0.031106561,0.018072492,-0.063887216,0.031774763,0.0036101898,0.011265041,0.050449878,0.0706259,0.028429171,0.05515753,-0.0002085915,-0.018901918,0.08410744,0.0072802305,0.067578435,0.051914126,-0.05294967,-0.051719386,0.047988877,-0.017580917,0.00515997,0.0465747,-0.037822846,0.022323763,0.049694337,0.00082874193,-0.01809623,0.05705567,-0.053763665,0.00684919,0.09531585,0.0776154,0.039143033,0.054415293,0.024658289,0.023075424,-0.0175036,0.046400763,0.10710374,0.056538776,-0.038179126,-0.044521686,0.020831004,0.025565997,-0.047205336,-0.013843161,0.049015373,-0.026855415,-0.01934522,-0.103576764,4.947061e-33,0.01106141,0.009446433,0.006401083,0.0061342726,-0.039244913,-0.017816024,-0.10727225,-0.04916151,0.013485256,-0.09112277,-0.061629254,-0.021662362,0.058674652,0.01383387,-0.039253548,-0.060075846,-0.0061523104,-0.0031097764,0.055364724,0.03587966,0.0015799612,0.07754319,-0.008202688,0.006366346,0.057193637,0.08310522,0.02866442,-0.051103488,0.05294296,-0.028462203,0.10821975,-0.1215766,-0.08541973,0.043744933,0.11483795,0.024069304,-0.009896536,0.009379172,-0.026774326,0.027515696,-0.050202277,0.042980634,-0.03614385,-0.004164442,0.09504867,-0.057727203,-0.07716231,0.10097827,0.018569896,0.05486094,0.020592988,0.018501468,0.081365876,-0.032117233,-0.025242815,0.051874064,0.023130532,0.029429337,-0.025931474,0.05474521,0.039967086,0.0554479,-0.041273143,0.06636885,0.023359817,0.026741859,-0.018297352,0.005814397,0.012771559,0.05236971,-0.10023124,-0.04901903,0.046620972,0.049489442,0.034128625,-0.005878161,-0.041352615,-0.08050759,-0.04753002,0.033174913,-0.023132937,-0.004797418,0.029943775,-0.094938025,-0.116560206,-0.00439028,0.014994421,0.011488234,0.023446634,-0.043230407,0.10022426,-0.042918514,-0.063627526,0.0281812,-0.028517066,-5.630436e-33,0.09031145,-0.07281623,0.04565164,-0.09453453,-0.07550376,0.046470035,-0.01416168,-0.13179848,-0.079622395,-0.016769897,0.058756992,-0.015569243,-0.0779455,-0.043865964,-0.0038306012,-0.028185219,0.038684495,0.08701857,-0.033417735,-0.003987726,-0.11148199,0.0748572,0.093978114,-0.0013415125,0.030590905,0.02234357,-0.006623176,0.056365505,0.057794075,-0.00018792451,-0.022478241,-0.020587277,-0.030279199,-0.016800195,0.012439561,0.033992734,-0.016832206,-0.008108168,0.023823394,0.049825925,0.03341077,-0.042930692,0.022211848,0.088656075,0.043687295,0.017125573,-0.09609893,0.019919708,-0.032986347,0.019986741,0.04290463,-0.014735726,-0.061024778,0.005748922,0.086375825,-0.01810424,0.081458315,0.055907175,0.021092966,-0.021190125,0.0007788579,-0.032365702,0.06333932,0.032355454,0.024312949,0.106763214,0.013324573,0.1261194,0.001372407,0.036091726,0.08115821,0.0732571,0.032349236,-0.042786844,-0.04456608,0.04477254,0.004721251,-0.008275728,-0.019564247,-0.042693987,-0.054557245,0.014979642,-0.03758927,-0.026527239,-0.08363781,-0.09621295,-0.00817896,-0.026966846,0.00023952559,-0.044669792,0.016148703,-0.04466093,0.033299305,-0.0072131157,0.03465857,-3.777188e-08,-0.033559,-0.006528017,0.031676162,-0.059239972,0.02366322,0.029679669,-0.013239373,-0.0799253,0.06530677,0.028921189,-0.00033089868,0.04786372,0.10467729,-0.045562338,0.037252963,-0.020780347,-0.0020609698,0.020965448,0.0047285953,0.014819393,-0.08590991,-0.023418667,-0.17989238,0.07636963,0.0033415293,-0.08434766,0.007682929,0.012573174,0.06201668,0.019789306,0.0050835744,0.028252311,-0.013063394,-0.043923207,-0.07802033,-0.03635327,-0.019387804,-0.057643864,-0.07961878,0.013250959,-0.04309255,-0.029628353,-0.085814334,-0.008125336,0.019896125,0.0066644913,0.036181774,0.002896841,-0.024141878,0.008378504,0.029596832,-0.04275737,0.03344775,-0.025814127,-0.1303467,0.049922973,0.028308595,-0.051339123,-0.02495264,0.05063761,-0.016377972,-0.014333426,0.12126553,-0.034695797 +1.14.13.82,Forms part of the vanillin degradation pathway in Arthrobacter sp.,384,1.0,-0.008492579,-0.024629077,-0.05523064,-0.015194815,0.0461372,0.0034220344,-0.0386973,0.034160946,-0.005172914,-0.020484425,-0.029829033,-0.037267666,-0.072846964,0.06935062,-0.034081344,0.050887447,-0.07713014,0.036931008,-0.0070796497,0.047780417,0.007286274,0.03658022,-0.02945713,-0.03012334,-0.03151234,0.053722475,0.034794647,0.019592427,-0.018794384,-0.063208476,-0.022731999,0.028583525,-0.015769817,-0.016236402,0.10108118,0.057290237,-0.046004526,-0.011172269,0.06698632,-0.038355175,0.055945978,0.016030356,-0.09201775,-0.09947709,-0.01173412,0.008976728,-0.024664886,-0.057071667,0.07286303,0.0012984618,0.035376415,-0.047648028,0.03731078,0.034904737,0.011158681,-0.08181942,-0.007606974,-0.03690374,-0.07081367,0.011879808,0.012685117,0.056170326,0.026458824,-0.0036936903,-0.073749244,-0.024990702,0.03395623,-0.022055797,-0.065699175,0.036795866,-0.10726402,-0.02779515,-0.04221039,0.09516568,0.021961508,0.08641322,0.0005538647,-0.068402424,0.016148724,-0.09266969,0.010712549,0.016870853,0.040143345,0.11943586,0.00029021734,-0.02928283,0.050214782,-0.091787435,0.04568675,0.075902976,0.050942168,0.04823185,0.019040724,-0.06619711,0.06025004,-0.035048477,0.07490633,0.0082844375,0.0032914865,-0.022900239,-0.10819108,0.041150708,-0.0126441745,-0.12770113,-0.0025557936,-0.012264029,0.001741221,0.09316677,0.077220954,0.0054526636,0.025372759,-0.009676262,0.071493454,0.021916999,0.023693953,-0.014551368,-0.050971217,0.003487898,-0.043505564,0.05325692,-0.028203089,-0.030819172,0.039158598,0.028696176,-0.012113257,-0.04665778,0.010269402,-1.5626491e-33,0.036600754,-0.03143265,0.011401203,-0.017648483,0.014829897,-0.038358096,-0.082092755,-0.012615361,0.075765684,-0.024294198,-0.06448281,-0.09972588,-0.014134902,0.011688866,-0.024303997,0.056227695,-0.03248547,0.05021484,0.0055427733,0.008070892,0.0066393926,0.06830062,-0.074018806,-0.04101833,-0.020314723,0.120729186,-0.029796446,0.0043648966,-0.10051062,-0.019244406,0.06601244,0.023869846,-0.10098491,0.007492564,0.033960164,0.033094022,0.01752087,-0.014289465,-0.034853242,-0.03940997,0.03410936,0.029587379,-0.015898084,-0.087262936,0.037749853,-0.050231718,-0.03267487,0.10441263,-0.021535281,0.030447515,0.014964056,-0.015700031,0.07865678,0.0185482,-0.02874141,-0.003854294,0.0026417912,-0.057750184,0.07236542,0.0032713516,0.06438803,0.060815748,-0.03761194,0.033435047,0.07087896,0.013451913,-0.07144608,-0.101926304,-0.02117904,-0.030323407,-0.006450055,-0.034222983,0.07280085,-0.017709197,0.026226915,0.02232086,-0.07916808,0.04316467,0.021418441,-0.008171617,-0.06946771,0.023569835,-0.03595596,-0.086377546,0.027721984,0.04719067,0.039142005,-0.015387423,-0.046807744,0.004332781,0.061448205,-0.10885237,-0.1546023,0.012596055,-0.018370172,-2.953204e-34,0.06564348,-0.013759495,0.004980927,-0.009151027,-0.037530605,0.013417789,-0.08111937,0.075522214,-0.0028593275,0.015089538,0.08006531,-0.0056519527,-0.011573926,0.009029457,0.047126643,0.01785294,0.031804614,0.02294858,-0.013434751,-0.07380418,-0.07226508,0.057700206,-0.011401461,-0.00046867802,0.028190035,0.013610084,-0.039598722,0.078114815,0.059597608,0.026247678,0.0059606414,0.057078443,-0.0043839407,-0.035402052,-0.009473361,0.017136788,-0.037427872,-0.04570892,0.0886405,-0.049854014,0.07842823,-0.04480156,-0.02038195,0.0034389223,0.051787008,0.025505092,-0.074064575,-0.0068314523,0.08013677,-0.018364023,0.01917258,-0.021469887,0.001498484,-0.0346166,-0.018760053,0.11856446,0.058129586,-0.00479855,-0.005206807,0.0067170477,0.00064877735,0.059377965,0.1018539,0.0742845,-0.07383534,0.06917311,0.034675334,0.104737274,0.060015466,-0.1044221,0.09098605,0.05194167,0.13856027,0.03632397,-0.0118332105,-0.094139375,-0.017802631,-0.0062395367,0.034091722,-0.033224367,-0.07343084,-0.035199087,-0.054220118,-0.03656561,-0.09191798,0.0038645626,-0.06746868,0.03523117,-0.047346562,-0.02288726,0.01899439,-0.048390318,-0.051887833,0.06165164,-0.023450011,-2.0679119e-08,0.04913092,0.00548571,0.12704681,-0.04841126,0.06857447,0.016762367,0.041557208,0.1055632,0.051208913,0.0244218,0.086233355,0.034024343,-0.034172513,-0.054837964,0.009584261,0.065758206,-0.009897845,0.017749475,-0.020448217,-0.043881867,-0.04272146,-0.084170945,0.01871034,-0.007173708,0.048077837,-0.09279327,-0.0022076091,-0.0048076045,-0.04660722,-0.052295078,0.0147422245,0.08488557,0.056073338,-0.011771032,-0.049584605,0.0013757293,-0.05275867,-0.09133425,0.009387955,0.062837034,-0.07188382,0.032131348,-0.10127294,-0.04928522,0.038975418,0.038793225,0.051580064,0.016515756,-0.07410744,-0.10836423,0.014333736,0.035121486,0.017807437,0.011169554,-0.07606245,0.041517865,-0.0118615925,0.00044465312,0.048880167,0.048785195,-0.059653208,0.001760202,0.08909769,0.03260976 +1.14.13.83,"An iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively.",384,0.99999994,-0.0776037,0.023530109,-0.10761612,0.00017660898,0.07803883,0.11186108,-0.08835043,-0.01929889,0.05937875,-0.031822335,0.021812642,-0.02909349,-0.08364793,-0.068048224,-0.030703012,0.011175434,-0.0814376,0.047664262,-0.08602808,-0.030357657,0.020704864,0.050142493,-0.0045484686,0.02275385,0.02888667,-0.046683483,0.025847888,0.043559253,-0.017762145,-0.0027457417,0.03479708,0.035156794,-0.0019220624,-0.020072205,-0.031943634,0.09009937,0.0030245066,-0.09237908,0.073563434,0.03209843,0.0018466453,0.05197548,-0.018899629,-0.0050507914,0.016216287,-0.022099143,0.012120219,0.011632747,0.021236923,-0.049345624,-0.02977503,-0.0057548513,-0.063367195,0.008772745,0.017935054,0.04296718,-0.080664165,-0.053173713,0.06809902,-0.010769798,-0.025504554,-0.029926559,-0.02954391,0.019185826,-0.0066782455,0.057751194,0.049922366,-0.048573725,0.03584927,-0.046659674,-0.040024646,-0.027788198,-0.0053203315,0.0026452544,-0.09156731,0.11057371,0.00787512,-0.021131672,0.046041094,-0.057042412,-0.02079612,0.03380874,0.022405015,0.05796653,0.027757669,-0.030467773,-0.04644258,0.014385284,0.008481312,0.09129207,0.0018583816,0.0040251967,0.036345728,0.022240885,-0.12391682,0.05711625,0.03450921,0.04930971,0.068151444,-0.001423288,0.022614064,0.0878487,-0.0030018417,-0.03771424,0.06389432,-0.04640458,0.053266004,0.18183565,0.04015795,0.067559354,0.01231169,0.01495844,-0.020498883,-0.03766372,0.04023589,0.12247937,0.05504615,-0.03510923,-0.051688474,-0.008774989,0.056600124,0.025143754,0.05674186,0.013108822,-0.08430386,-0.051193845,-0.07143988,2.5981395e-33,0.08348644,0.024748633,0.053722892,0.042806983,-0.08222827,-0.0062126345,-0.13265637,0.02454637,0.0005399414,-0.022069057,-0.037852395,-0.05075964,0.011246047,-0.0016089745,-0.036924575,-0.095708914,-0.020300841,-0.06907013,0.07157143,0.007348442,-0.03050953,0.06265184,-0.023337042,0.018319406,-0.0021130913,0.06384902,0.0136687225,0.039860997,0.01772942,-0.0067405025,-0.0141831795,-0.08655035,-0.049179353,-0.03895752,0.03562854,0.016113475,-0.052264713,0.039318446,-0.0015821367,0.06520349,0.043176807,-0.026540298,-0.10124345,-0.06412124,0.100454696,-0.031960808,-0.081193924,0.07457116,0.006833,0.011099519,-0.026414156,0.015893972,0.12093895,0.094781935,-0.06654228,-0.020886295,0.006671382,-0.00042257286,0.018356469,0.07944742,0.043841224,0.05268432,-0.018562103,0.12416603,-0.017368913,-0.004079936,-0.06036752,-0.016446395,-0.0017864482,0.025041522,-0.024136616,-0.075607546,0.04124384,0.011357903,0.069491014,0.02578861,-0.07633521,-0.041047208,-0.026561765,-0.003705994,-0.036015913,0.04638276,-0.02321124,-0.04691708,-0.10568168,0.038099688,-0.051857453,-0.054983,0.028177928,-0.021464314,0.04519201,-0.040129513,0.013602381,0.013841864,-0.025986116,-3.6334295e-33,0.112655,-0.037621956,0.06497702,-0.09737519,-0.03504889,0.05193864,0.115042,-0.12158996,-0.07281722,-0.05830588,0.06439995,-0.048347298,0.0037514889,-0.06142236,0.010647916,0.038991414,-0.018920949,0.07411225,0.05126505,0.04071961,0.0036655485,0.017204158,-0.05265262,0.020261211,0.016689993,0.07165816,0.05330847,-0.033058114,0.09090934,0.06995583,-0.020525059,-0.010521911,0.02099726,-0.009851089,-0.060173355,0.086258546,-0.049010154,0.004794745,-0.006830061,-0.030046867,0.003482843,-0.036415856,-0.0071541546,0.06131329,0.04458139,0.07433777,-0.049580377,0.029131358,-0.037661,0.037704483,0.032745518,0.009375342,-0.055181254,0.015122123,0.051787566,-0.011011942,0.069387905,-0.06949068,0.035200045,-0.043114487,-0.04593652,-0.019254824,0.04560756,-0.06275797,0.03792557,0.022433389,0.029153075,0.09707038,0.020753335,-0.013925161,0.029106217,0.026209412,0.03321837,-0.041265443,-0.024678692,0.007631048,0.003074649,0.012731311,-0.038963236,-0.01838509,-0.07254032,-0.005259898,0.009893157,-0.0055195116,-0.09326125,-0.062412243,0.037728865,-0.006333275,-0.03940503,0.05390329,-0.073536456,0.015348308,-0.03842034,0.04710968,0.03412634,-4.702112e-08,0.010433021,-0.060381275,0.09001713,-0.010924159,0.034990996,0.071555756,0.012753909,-0.0073444746,0.024061998,0.011321338,-0.007943489,0.097858496,0.026495079,-0.027674042,-0.10146588,-0.0363092,-0.10308188,0.010743482,0.017727055,-0.04375999,-0.045811005,0.020254347,-0.041637085,-0.060015827,0.052072998,-0.15889046,-0.093729615,0.06302453,0.02089925,0.002930109,-0.004079177,0.051735405,0.01262208,-0.05831385,0.0057614134,0.0068396796,-0.029247304,-0.040042114,-0.038118627,0.014558996,-0.097358294,-0.021693401,-0.084796734,0.01636164,0.012719577,-0.06577828,-0.017462438,0.07253495,-0.05017288,-0.000566231,0.008926994,0.007682533,0.0089106625,-0.026336597,-0.074530005,0.0810744,-0.01598604,-0.09072861,-0.017382005,0.007542301,-0.024031011,-0.04873362,0.06410136,-0.035113208 +1.14.13.84,"Contains FAD. The enzyme from Pseudomonas fluorescens ACB catalyses the conversion of a wide range of acetophenone derivatives. Highest activity occurs with compounds bearing an electron-donating substituent at the para position of the aromatic ring [1]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1).",384,1.0,-0.047539745,-0.047574867,-0.112399474,-0.0183208,0.08925865,0.073203735,-0.07248,0.07153518,0.0013458926,-0.010612436,0.0029388263,-0.015829664,-0.081690855,0.035111453,-0.058462586,0.023578558,-0.04296686,-0.0118214665,0.0026087393,-0.008095287,0.017276134,-0.016859509,0.00089827576,-0.04037873,0.035310395,0.017203534,0.0037316463,-0.060381204,-0.033580184,-0.054959357,-0.0012475201,-0.039032903,0.00919602,-0.02360534,0.036610562,0.00019005331,-0.011997028,-0.0042488845,0.083805226,0.011991018,0.042553913,0.00040504578,0.009553226,-0.061867844,0.0358361,-0.017968474,-0.01241128,0.02993266,0.012676585,-0.020990305,-0.02604024,-0.027084762,-0.012321932,0.041408397,-0.018480783,0.04327217,0.029516388,-0.06258776,0.007913458,0.0226994,0.0010829156,-0.025709355,-0.026499832,0.024926417,-0.01838583,-0.061970193,-0.0071853935,-0.049838055,-0.008885748,-0.011086693,-0.03559293,-0.066525854,-0.023042746,-0.0055356314,0.08211345,-0.019032074,-0.06260324,-0.07667857,0.06855619,-0.039434593,0.017198361,-0.016776958,0.055093627,0.1060715,0.094165094,0.011942767,-0.0023128546,-0.0021804923,0.027591271,0.047373638,-0.040671095,-0.03172256,-0.06251161,-0.027728109,-0.12846912,0.06375828,0.059061117,0.04009403,0.017705295,-0.00012569183,0.020416403,0.074965365,-0.0081522465,-0.14478649,-0.06002936,0.042569347,0.014272139,0.118869096,0.023369947,-0.0024248362,-0.045624007,-0.015391973,-0.021415891,-0.1267698,-0.029950503,0.053052396,0.004050955,-0.09813389,-0.052915573,-0.014718573,-0.026659481,-0.012160896,0.05703321,0.10163633,0.023076981,0.028350152,-0.1004827,2.571378e-33,0.02131336,0.03116487,-0.027464401,-0.060381304,0.01366763,-0.005126259,-0.069845304,0.0248863,0.018722817,-0.0036519093,-0.05805506,-0.039776295,0.0026892023,-0.034603477,0.030285992,-0.009359491,-0.020007908,-0.07637241,0.01292761,-0.020836594,0.0749473,0.0030322378,-0.057260603,0.066305436,0.038170595,-0.04469641,-0.026214864,0.082974985,-0.014852331,0.010268403,0.008698192,-0.028215665,-0.09372406,-0.031914055,-0.009967328,0.04012493,-0.055653606,-0.017517403,-0.03501726,0.06807476,0.06976469,0.030739672,0.031437427,-0.02001522,0.047933806,-0.06051864,-0.02524189,0.16586192,0.030294927,0.08169468,-0.0073049767,-0.054951344,0.1016511,0.025837354,-0.041335907,0.048085336,-0.054826766,-0.01028885,0.11149237,0.057495054,0.053139098,0.004904339,-0.060150757,0.06662002,-0.11114426,0.044176277,0.023020102,-0.026005812,-0.0042929766,0.06390036,-0.03810572,0.008518599,0.05461574,-0.0022004896,0.08026737,-0.043229986,-0.004215954,-0.025957221,0.06111224,-0.023233091,-0.0075905044,-0.03830349,0.029890861,-0.036630064,-0.025395537,0.017697008,-0.013939651,-0.050703745,0.0011871859,0.04532226,0.08435819,-0.06562613,0.0036728838,0.021569535,0.01475493,-2.0729314e-33,0.08274501,-0.07405478,0.05020828,-0.14086133,-0.03576996,0.07433582,-0.014190356,-0.03991914,0.04071663,-0.03299769,0.035145964,-0.006857906,0.022780469,-0.07694475,0.004308021,-0.030523332,-0.001758184,0.035956707,0.085400395,0.024764216,-0.012630095,0.07863634,-0.0039667953,0.045668036,0.06792304,-0.013471351,-0.08291709,0.076979235,0.10557195,0.06307343,-0.043583505,0.03575854,-0.027839905,0.0135374665,-0.08325424,0.06396568,-0.022674825,0.031157281,0.008040999,0.07695987,0.024512032,-0.0072895093,-0.044610023,0.10927299,0.06302357,0.10509854,-0.13470973,-0.011566916,0.010072662,-0.11837931,0.05751384,0.015349388,-0.0013188386,0.004493707,0.06541926,0.06429708,-0.01632852,-0.029376453,-0.01590581,-0.0503966,-0.0045126798,-0.05312531,-0.011664412,0.007270225,0.06295278,0.05323663,-0.04617311,0.13073997,-0.06503194,0.044458855,0.052286092,0.054191362,-0.04092946,0.062714584,-0.021886641,-0.0731229,0.016016591,-0.008492846,-0.02115215,-0.0012790138,0.03017718,0.028851693,-0.026547855,-0.0704637,-0.056289695,-0.028645758,-0.002421574,0.04258686,-0.03653963,0.03476627,-0.041090753,0.050112765,0.02427122,0.017648492,0.020628478,-4.2234674e-08,0.00027240702,0.010814211,0.10155109,-0.033912037,0.04837718,0.050900508,0.0382283,-0.0030459582,0.034860138,-0.03998277,-0.11319716,0.12121546,0.06847162,0.0020688844,0.021942971,0.024612457,-0.049757347,0.0633694,-0.0062151817,-0.0028643915,-0.052705016,0.053367767,-0.07015732,0.00711532,-0.014405414,-0.007679125,0.059989993,-0.023136394,-0.02077556,-0.0024586485,-0.07885373,0.0027895567,0.03428378,-0.03621338,-0.061043818,0.056804378,0.009627298,-0.052745096,-0.09007973,-0.022665722,0.026454533,-0.068693794,-0.07563464,-0.010886798,0.00485571,-0.013210375,0.027227806,-0.01794551,0.02946869,-0.04874381,0.1000907,-0.026769364,0.008020345,-0.07534562,-0.100974455,0.027686372,-0.04070927,-0.074271254,-0.02787931,-0.05372967,0.066022806,0.028958857,0.14283293,0.06597199 +1.14.13.85,"A heme-thiolate protein (P-450). Glyceollins II and III are formed from 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan whereas glyceollin I is formed from the 4-isomer.",384,1.0,-0.012466583,-0.060398918,-0.049589265,-0.044261254,0.03802396,0.03702375,0.024501974,0.0700499,0.007870088,-0.01412827,-0.0045657386,-0.013533361,-0.1321647,-0.059784174,-0.038823433,-0.080708995,-0.03962569,0.017893668,-0.07341044,-0.0953605,0.036633234,0.03935222,0.030126806,0.024406178,0.003663975,-0.013069035,0.032551073,0.033451278,0.045085106,-0.05239756,-0.0278377,-0.05107079,-0.0021865882,0.008858978,-0.022695953,0.026773615,-0.034157313,-0.03880584,0.020738015,-0.07879454,0.14128734,-0.05939139,-0.04646593,0.020396007,-0.014820474,0.044034526,-0.015703375,0.05398676,-0.011323113,0.05643527,0.03469487,-0.07517966,-0.058391374,0.058229186,-0.06095842,0.03691899,-0.014731329,0.10143085,0.014527497,0.05582005,-0.021538993,0.030327527,0.068568684,-0.003840421,-0.0039980235,-0.061219666,0.08562742,-0.019981142,-0.0677235,0.0005616529,-0.027506353,0.03470259,-0.059721347,0.014300384,-0.03554942,0.09342838,-0.067305654,-0.0018892126,-0.0026039528,-0.041877124,0.029843325,0.0035480333,0.09043298,0.14287937,-0.037320245,-0.07375677,-0.035507504,0.060882047,-0.07512775,-0.066096485,0.03664229,0.04179044,-0.0057091406,0.0076119397,-0.025269656,0.05520786,0.055636797,-0.0027609353,0.026777728,-0.008097495,-0.015292604,0.0026488588,0.007447356,-0.11779599,-0.06955739,0.070002526,-0.08919603,-0.042514272,0.088723496,0.0077205827,-0.017507821,0.0031783124,0.05482146,-0.0503597,-0.056182213,0.044575438,0.0013979696,0.03305331,0.038104378,-0.0726786,0.0028320535,0.021346962,0.07970066,0.016171927,-0.13605753,-0.03599614,-0.062649556,3.6908572e-33,0.02458305,0.0052117696,0.0439451,0.051475175,-0.018227734,-0.01103081,-0.0871483,-0.009860963,-0.029411888,0.024526872,-0.024544323,-0.09992357,0.02084734,0.013569038,0.013226886,-0.0145505415,-0.034808945,0.01704383,0.047908943,-0.036124054,-0.06826589,0.052288413,-0.030667039,-0.03824162,0.07786961,0.06509885,-0.018895084,0.0015951595,0.041519385,-0.0076624528,0.01044051,-0.063126385,-0.052934844,-0.037769046,0.050215833,-0.026799403,-0.0014855545,-0.04302715,-0.0051833033,0.013388956,0.03196171,-0.04735884,0.035494063,-0.09445279,0.039294217,-0.0175654,-0.042154524,-0.016978152,0.10358409,0.039458856,0.012842544,-0.10113918,0.09533671,0.040346123,-0.062486753,0.0012638726,-0.018856626,0.08967703,0.061008852,0.10279749,0.08701208,0.13376471,-0.017952215,0.0063615763,-0.01502379,0.10764211,-0.0791251,0.02266782,-0.019354405,0.048480213,0.03573959,-0.004005683,0.089072675,-0.017171318,0.11007612,-0.08101645,-0.0042183492,0.1083515,0.002142597,-0.024219364,0.04396606,0.029626992,-0.035335235,-0.047978364,-0.085376374,0.0021454056,-0.058084585,0.0012668619,-0.0061565842,0.047953736,0.044680826,-0.010217431,-0.001572081,-5.2168678e-05,-0.045981634,-4.3965285e-33,0.08327094,-0.05470381,0.045879863,-0.03983993,-0.027430154,0.053659793,0.049498796,-0.07737256,-0.05911289,-0.026822416,0.096879944,-0.038588554,-0.06088551,-0.06798234,0.0060861926,-0.0168655,-0.03614987,-0.011312851,0.02429166,-0.027101588,0.036103196,-0.045366697,-0.02289652,0.04258576,0.046402767,-0.015616266,0.00504043,0.037528284,0.040819097,0.04411581,-0.007442029,-0.016872821,-0.062443078,-0.042229973,-0.11201198,-0.056712765,-0.009653863,-0.0029790082,-0.049943216,-0.06652443,-0.035198744,0.055233594,0.12317435,0.03869116,0.041462477,0.08878011,-0.02902525,-0.027997658,-0.03781113,-0.0018757072,-0.011268521,0.0014995661,-0.04365894,0.019007077,0.03711592,0.04704357,0.013663614,-0.02107795,-0.02186903,-0.056919117,-0.038118057,-0.055343147,0.04754555,0.06349219,0.071562424,0.049629204,-0.062839285,0.06157505,0.05495592,0.019060012,0.023895262,-0.06222616,0.056988038,0.018064834,0.01642177,0.0371149,0.06391805,0.026423648,0.041739628,-0.056956984,0.00089593517,0.018291589,-0.07412916,-0.041634083,-0.02141507,-0.03411835,-0.042212524,0.11929233,0.047686312,0.017982878,-0.050550546,0.065546215,-0.044918127,0.034995575,0.06970416,-4.30747e-08,0.067023076,-0.14076583,0.02912111,-0.06741279,0.020907937,0.012592956,0.023253284,0.059940793,-0.019136496,-0.025542289,-0.023737736,0.0041521676,-0.031913437,-0.05641026,-0.03581168,0.050251573,-0.044390667,0.05654775,0.032327592,0.017929353,-0.061180785,0.033856712,-0.06463469,0.00915855,0.021021456,-0.026405439,-0.03370736,0.018875124,-0.006450183,0.04599772,0.03358213,0.060277052,-0.047360074,-0.055925306,0.02516157,-0.010239509,-0.07568689,0.03145349,-0.056112617,-0.04750588,-0.003859335,0.038888186,0.013669638,-0.033027712,0.03253948,-0.029342525,0.06647997,0.05704146,0.0036723176,-0.024657182,-0.043980487,0.0005179969,-0.0096895285,-0.04087616,-0.12882458,-0.028174771,-0.0062298053,-0.025208615,-0.0020984963,-0.038680166,-0.010535593,-0.046579715,0.17372777,0.072004646 +1.14.13.86,"A heme-thiolate protein (P-450). EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on 2-hydroxy-2,3-dihydrogenistein with loss of water and formation of genistein. This may occur spontaneously.",384,0.99999994,-0.048439793,0.028736949,-0.036829747,-0.02689047,0.07136862,0.016009888,-0.025264516,0.06017698,-0.030157598,-0.064605616,0.0017893079,-0.08313142,-0.078996725,-0.021810489,-0.07914808,-0.004615276,-0.07671708,0.017555123,-0.038207516,-0.031591624,0.0132861035,0.0051824963,0.007886499,0.004809579,0.03361496,-0.020891165,0.118764535,0.08738248,-0.0050393795,-0.04738271,-0.03047573,0.017412279,-0.051482204,0.019255865,0.0024791725,0.15648925,-0.060741223,-0.03568083,0.01838764,-0.032575406,0.13254999,-0.10811776,-0.06895085,0.022644078,0.012844598,-0.019333804,-0.08286475,0.056632612,0.02010185,0.01604259,-0.057546634,-0.08313885,0.06484277,0.07586316,0.016133858,-0.046966206,0.08436115,0.04484151,-0.006550551,-0.036202054,0.047209006,-0.02866682,-0.029838199,-0.059009988,0.05040321,-0.025877107,-0.004584427,-0.017025962,-0.0052957013,-0.06203165,-0.017342819,0.023423946,0.021736369,0.041837923,-0.07072338,0.083622456,-0.07248513,0.054796807,-0.041416634,-0.01725328,0.05526828,0.029138193,0.04264182,0.10630409,0.0115357265,-0.04322009,-0.011442158,-0.011062158,-0.04671972,-0.017233025,-0.0650932,0.052817255,0.01586275,0.020262588,-0.026246512,0.15332703,0.021709273,-0.061674546,0.048144586,-0.00318441,-0.023530163,0.050966784,-0.04557984,-0.034803785,-0.043786924,-0.0016269219,-0.052611426,0.009231441,0.066565365,-0.01356435,-0.00042458405,-0.0522568,0.021198992,0.017656468,-0.017052485,0.054047264,-0.02813265,0.023306567,-0.020899758,-0.052545402,-0.018677987,-0.011765302,0.03598589,0.0009251049,-0.04207182,-0.0023543986,-0.06335633,4.6424946e-34,0.12242133,-0.070337765,-0.018316668,0.071670815,0.052568525,-0.02973958,-0.121770546,0.034530915,0.009525995,-0.07266144,-0.08709495,-0.09461094,0.018076275,-0.064459756,-0.071415715,-0.09012023,-0.023838984,-0.018938221,0.031074226,0.031109175,0.022651669,0.07341419,-0.059098676,-0.0022377677,-0.01735365,0.07702497,0.015558789,-0.050030764,0.07480279,-0.013779274,-0.05405626,-0.08355823,-0.020110128,0.0051173912,0.020237818,-0.020557843,-0.042839468,-0.016165819,-0.024332624,0.04450441,0.05060895,-0.034027603,0.06065336,-0.12830108,0.07040901,-0.0054648877,0.026521888,0.019984428,0.002506027,0.043642458,0.02821837,-0.022369592,0.073476136,0.010103904,-0.049685974,-0.05909759,-0.009868991,0.02459635,0.02861056,0.059601896,0.06540701,0.096822456,-0.020080859,0.042927325,-0.085824914,0.006221555,-0.06948379,-0.034946878,0.006744666,0.02192984,-0.013896883,-0.025973668,0.043172672,-0.033171438,0.009894836,-0.037614968,-0.00488981,0.028370516,-0.01718333,-0.014164792,0.0356132,0.015796337,-0.026697483,-0.0012131509,-0.057643432,0.04203849,-0.001927935,-0.029989777,-0.004594056,0.0018302306,0.05266963,-0.005392648,-0.014160028,-0.056129817,0.05175617,-1.40750865e-33,0.08767991,-0.04763333,0.027966052,-0.02223474,0.042443182,0.07137447,-0.0013327425,0.014520143,-0.052373454,-0.012727126,0.11680345,-0.027301876,-0.075593226,-0.062952645,0.00013555371,0.082455575,-0.026523361,0.033044606,-0.0072639054,-0.010813293,0.010487159,0.062007718,0.02953235,0.09546519,0.087044075,0.032428876,0.1061757,0.0613336,0.0020430244,0.06886994,-0.03696978,0.04588617,-0.013170366,0.0071057063,-0.03218954,0.04451447,-0.0057065347,-0.039468065,-0.012861447,0.030265652,-0.05699489,0.035855897,0.06629201,0.055688564,0.034966446,0.101559,-0.05478743,-0.030382698,0.0015659889,0.008808819,0.07231317,-0.0052096257,-0.033175543,0.028927105,-0.039413173,-0.0059718015,0.027920518,0.08318715,-0.03847978,0.0054840827,0.014862352,-0.059575234,0.03801233,0.09195246,0.010002702,0.08599122,-0.056555137,0.111867234,0.07078405,0.048534494,0.07450582,-0.0053209225,0.031319097,0.035807766,0.035227075,0.029205022,-0.020380002,0.05084002,-0.0010937426,-0.0031147015,-0.045481764,0.070139274,-0.084332325,-0.08800748,-0.041361958,-0.10726497,-0.013569515,0.07942876,-0.07507171,0.030092135,0.0031671375,0.031536385,-0.13903837,0.06882832,0.075203545,-3.764973e-08,0.009548776,-0.11257774,0.03481652,0.0012837449,0.060254443,-0.07702342,0.069619186,0.051606577,0.09887981,-0.02333646,-0.053104177,0.0054161963,-0.0057962663,0.006300216,0.010944917,-0.011947296,0.03264913,0.03381982,-0.044017956,-0.00012919279,-0.00856621,-0.019883791,-0.08575838,0.018972032,0.011641018,-0.051347397,-0.04412084,-0.00053352275,0.059041418,-0.034922723,0.038833525,0.060840312,-0.0053005097,-0.06864574,-0.039803497,0.06225602,-0.05480435,-0.03620574,-0.025863737,-0.065104194,-0.016174942,-0.0042889793,-0.022750665,-0.032595683,-0.03187027,-0.043866348,0.034248453,0.05339665,0.012491491,-0.039049104,0.034374136,0.03961456,0.009611335,-0.047713213,-0.10755828,0.008464433,0.0025982072,-0.028528979,-0.0525733,-0.111895904,-0.00010772799,-0.011723978,0.1540972,0.008680901 +1.14.13.87,"A heme-thiolate protein (P-450). It probably forms 2-hydroxyliquiritigenin which spontaneously forms licodione. NADH can act instead of NADPH, but more slowly.",384,0.99999994,-0.07320688,-0.051804256,-0.01643871,0.008996394,0.0062409556,0.069648005,0.020092,0.07640112,0.04928849,0.03524704,-0.0031076143,-0.016549278,-0.07015608,0.08136769,-0.00814533,0.017477525,-0.023938496,-0.023183525,-0.021892382,-0.026830958,0.03198363,0.07302167,0.018067354,-0.0035551677,0.02336708,0.013837196,0.035266317,0.0098858625,0.069236346,-0.08559079,-0.060991492,0.013554508,-0.09355076,-0.028866585,0.028381204,0.09337574,-0.042411607,-0.0032523097,-0.012847512,-0.060588982,0.11590452,-0.097584635,-0.08704669,0.012731155,-0.041068062,-0.016281154,-0.021701304,0.08563054,0.046135828,0.023786502,-0.036872834,-0.058651883,-0.046230257,0.06882944,0.022555115,-0.07466699,0.013820984,0.05227076,-0.010492714,-0.09068937,-0.07116003,-0.0015497737,-0.031644393,0.026246777,0.0447712,-0.061449792,0.05521158,-0.0055640745,-0.026208837,-0.055298,-0.009368433,-0.01011292,0.020740228,0.056307845,-0.024224684,0.032431282,-0.060635813,-0.087177664,0.013464428,0.041917514,0.062434018,0.104503065,-0.03473405,0.10531196,0.022253552,0.0070072706,0.0069964873,0.04474119,-0.09239101,-0.0803242,-0.061477084,-0.018705504,-0.04004417,0.009728246,-0.13768736,0.05754661,0.080808945,-0.05873652,0.018373776,0.006185466,-0.005802202,0.101613246,0.0274327,-0.03792899,-0.068823904,0.016317056,-0.08293352,0.048168797,0.0051272516,0.02559479,-0.026209736,-0.052162033,0.04333804,-0.049027327,-0.030964654,0.095671624,-0.041821633,0.0219903,-0.069030344,-0.05015166,-0.023857541,0.0038719832,0.006165096,0.040366095,-0.029274665,0.0038168803,-0.111850955,1.6645799e-33,0.14642964,-0.020121027,0.03961732,0.0860678,0.008479773,-0.0050221025,-0.09557087,0.045199037,0.007479396,-0.009193965,0.015662568,-0.12893161,0.02615461,0.004973132,-0.009853734,-0.039893307,-0.08049289,-0.011242152,-0.026930036,-0.03168854,-0.044073172,0.11088207,0.02493844,-0.0004563618,0.00034614227,0.040166423,-0.027594754,0.0042536412,0.018284123,0.0021456187,0.04395754,-0.027649298,-0.06305728,-0.019914722,0.03641456,-0.025128022,-0.072513394,-0.053959128,-0.013056673,-0.009442552,-0.02952404,-0.019468622,-0.013791138,-0.098105505,0.056678843,-0.1311861,-0.02246742,0.018641448,-0.038721804,0.015280195,0.09320786,-0.053630523,0.124159515,-0.009384329,-0.08637826,0.00899434,0.0069303582,-0.0633149,-0.033246975,0.08173504,0.14851254,0.015461788,-0.07232991,0.09056581,-0.056632407,-0.01458482,-0.12541631,-0.08523829,0.031898376,0.078069896,0.022803057,0.009271181,0.049407065,-0.041268338,0.05303356,-0.044887986,0.023371112,0.0316421,0.024363907,0.010754038,0.016091635,-0.08575909,-0.053483445,0.036107883,-0.04893846,0.03773873,0.067309506,-0.017697683,-0.05739151,-0.011667531,0.052241478,-0.060466137,0.008697943,-0.051996272,0.011569727,-4.0491457e-33,0.105601,-0.03988925,0.036995135,-0.07050198,0.024224976,0.059161425,0.032629035,-0.015306748,-0.049190674,-0.04800154,0.08547007,0.021802502,0.026939817,-0.01694549,0.052933972,0.022341287,-0.019931054,-0.030404491,0.04448642,0.034267463,-0.0075898985,0.05163582,0.012505348,0.009028696,0.10162301,-0.045026526,-0.011630437,0.032842178,0.031229645,0.06443836,-0.07664971,0.03504131,-0.06975226,-0.044555854,-0.017142726,0.020164074,-0.03484793,-0.052087177,-0.01672133,-0.017224247,-0.028184088,-0.0018183861,0.058911778,0.027408011,0.08353798,0.047993388,-0.07111412,-0.03922437,0.05657001,-0.020210022,0.03530745,0.02479114,-0.054658778,0.0325876,-0.0038179334,0.02770519,-0.11291711,0.05262363,0.06462632,-0.028145796,-0.010197713,-0.019408166,-0.003977435,0.04783778,0.05445568,0.006461597,-0.048898928,-0.027120065,0.04349512,-0.010442793,0.09503559,0.07013406,0.044511054,0.022314839,0.026549485,-0.08589583,-0.05335162,-0.0056099924,-0.007185448,-0.04386244,-0.028731175,0.035127528,-0.06955383,-0.025868542,0.011749606,-0.023370488,-0.0011862706,0.021751124,0.017292602,0.004217738,-0.009934578,0.08884891,-0.040557127,0.06987976,-0.0010902052,-3.701088e-08,0.027602112,-0.074599825,-0.0050654765,-0.02104927,0.0038701247,0.0029804949,0.090379156,-0.015116716,0.046430696,0.0034400534,0.00085375906,0.07700954,0.06527257,-0.013494459,0.05707686,0.007581575,-0.05609904,0.03329169,-0.03366675,-0.07336574,-0.040388923,-0.0011532146,-0.01787579,0.05578552,-0.037188698,-0.037434947,-0.040190134,-0.041103408,0.04121956,-0.0819201,0.03197045,0.054826897,0.029760169,-0.07852322,-0.0054966193,0.10948114,-0.056408886,0.0047481353,-0.017292805,0.028417135,0.017434692,-0.03747322,-0.041017976,-0.016127463,0.028431961,0.018551737,0.040962853,-0.014916622,-0.0115994215,-0.0082788365,0.07265576,0.040221427,-0.022281159,-0.07022229,-0.09421277,0.031318523,0.006224714,-0.040993553,0.013030828,-0.09097301,0.048195574,0.028158067,0.12678926,-0.0005825757 +1.14.13.88,"A heme-thiolate protein (P-450). The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin. NADH is not a good substitute for NADPH.",384,0.99999994,-0.05012004,-0.050789233,-0.06072568,-0.052571654,-0.02928202,0.012525104,-0.058401957,0.05886935,0.07127981,-0.0029749079,-0.035847876,-0.02430779,-0.07616127,0.07172868,-0.026269905,0.026584862,-0.028375465,0.058516476,-0.046643693,-0.03395111,0.06637604,-0.02855937,0.066884935,0.020965489,0.02117536,0.012274233,0.034804538,0.027088538,-0.032420557,-0.14539559,-0.010569733,0.013029259,-0.078803815,-0.06442429,0.023001615,0.06498321,-0.061409675,-0.013078284,0.049060084,0.009190163,0.04668508,-0.0136246495,-0.09318028,-0.037869275,-0.07065911,-0.03304767,-0.06280116,0.058554824,0.108295865,0.016111134,-0.0676706,-0.050331492,-0.039030924,0.081654906,0.021506626,-0.066762745,-0.025693446,0.030691652,-0.02884439,-0.0160593,0.0027434046,-0.010374436,-0.023054523,-0.03090714,-0.010885806,-0.033517987,0.012480056,-0.06584171,-0.04927065,-0.024706904,-0.032207374,-0.02063807,-0.000398498,0.06810127,-0.027987286,0.10642482,-0.01779855,0.017187666,0.0019489998,-0.010936035,0.029214121,0.107384205,-0.0075426265,0.11908392,0.12048268,0.024102164,-0.07070906,0.016427962,0.010407436,0.0053926045,0.07041142,0.043837495,-0.031887736,-0.0122923795,-0.05444479,-0.0015624432,-0.015056369,-0.013354459,0.0068816617,0.005043592,0.031620827,0.057386905,0.0007789523,-0.09227729,-0.044149876,0.012818261,-0.021794468,0.03719342,0.038819756,-0.0006428505,-0.022282211,-0.05127417,0.05380326,-0.0077034202,-0.073194206,0.10111382,-0.061897293,-0.04324655,-0.047640447,-0.047184244,-0.023879256,-0.026896928,0.06953022,0.050122276,-0.015225019,0.0010677878,-0.113226436,5.530388e-33,0.08948307,0.056874085,-0.014353701,0.043968327,0.0103172865,0.035482258,-0.09143594,0.091690525,-0.044630066,-0.060842045,-0.10168696,-0.007802587,0.044400644,-0.07044499,0.006471333,-0.057740707,0.020994384,-0.01885413,-0.017364714,-0.010008932,0.04551622,0.042326197,-0.061305095,-0.004255323,-0.05730814,0.05734552,-0.068329506,0.04694647,-0.0049351915,0.016865,-0.00808234,-0.12468323,-0.029689306,0.01203158,-0.00061837374,-0.07250599,-0.01297887,-0.06663577,-0.014433368,0.06946153,-0.024083074,0.019283714,0.025384419,-0.011182602,0.04477155,-0.09165149,-0.030889459,0.0363192,0.04533614,0.053229365,0.08354726,-0.030798145,0.1456235,-0.019154886,-0.12013726,0.025163624,-0.032140315,-0.03281749,0.059796322,0.10161152,0.0457899,0.048655573,-0.008537489,0.009463717,-0.03485081,0.0103188865,-0.09732862,-0.054055367,0.042443547,0.08417709,0.021965995,-0.016318832,0.0781813,0.03133185,0.07903039,-0.061620995,0.03755329,0.04878227,0.046183243,0.0015704465,-0.00081391324,-0.0018458022,-0.056372527,0.037056785,-0.066372,0.0162998,0.084573194,-0.03471949,-0.064427055,0.028064629,0.05193212,-0.097178414,0.01033136,-0.053371757,0.05435362,-5.911809e-33,0.1404392,-0.052642375,0.0514208,-0.12948087,-0.045370936,0.11256972,0.08302013,-0.055822335,-0.046600636,-0.03236646,0.06726207,0.022460693,0.0616596,0.0147754885,-0.024442315,0.023762258,-0.040523704,-0.023371946,0.015210691,-0.0066728904,-0.015222422,0.09921466,-0.027248029,0.047980726,0.029931622,-0.006678245,0.008350528,0.0028479553,0.031572398,0.06800013,-0.024254646,0.010620006,-0.0864451,-0.04199723,-0.021235805,0.083009295,-0.032257143,-0.030106872,-0.055446267,0.010775469,-0.055581022,-0.007974301,-0.033636343,-0.013960588,0.06303042,0.059371162,-0.088895954,-0.02288038,0.0059805172,0.005458858,0.06958231,0.050212998,-0.030069994,0.08205705,0.008941485,0.020741502,0.0012940132,-0.0019885004,-0.017882649,-0.02608507,-0.05325538,-0.049442075,0.065973096,0.021999452,0.018877182,0.053234454,-0.0064598154,0.003869144,0.08053131,-0.017970439,0.024182107,0.051075377,0.061262652,0.05782372,-0.0069530997,-0.001735059,0.031013435,-0.03169726,-0.00089489075,-0.026629193,-0.048659664,-0.017293813,-0.047785413,-0.07762266,-0.039658815,-0.025096482,0.06223086,0.08527045,-0.01929528,0.02935808,0.053700984,0.010554595,-0.019560557,0.08385154,0.08945153,-5.3789805e-08,0.017097913,-0.08630924,0.014215397,-0.0069175274,0.03851486,-0.0035338781,0.012894247,-0.07840278,0.01020779,-0.041331567,0.012112226,0.077885754,0.00034042614,0.024507504,0.049335573,0.07446036,0.028167272,0.0015726311,-0.011878429,0.018899724,-0.071595795,0.068523034,-0.08804961,0.0043449244,0.040760584,-0.084392525,-0.048368942,-0.0480544,0.0055276323,-0.032272838,0.03030747,0.03500088,0.009802469,-0.07594481,-0.0382068,0.033886973,-0.051153842,0.04095295,-0.05596035,0.04570413,0.018371355,-0.07446234,-0.06701938,-0.015237596,0.021003364,-0.01670205,0.0062884763,-0.016528018,-0.02257361,0.027671445,0.057813186,0.03287028,0.021753216,-0.081336394,-0.08004831,-0.02396171,-0.056586195,-0.07243273,-0.04088465,-0.032374058,0.021377297,0.0064036036,0.15770267,-0.011446787 +1.14.13.89,"A heme-thiolate protein (P-450). Acts on daidzein, formononetin and genistein. EC 1.14.13.53, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.",384,1.0,-0.07339669,-0.01371458,-0.0325539,-0.018603154,0.054210424,0.071506925,-0.02494563,0.10268757,-0.005440169,-0.05308513,-0.044551335,-0.01779856,-0.09591484,0.05353348,-0.047774386,0.05717491,-0.057854973,0.020288607,-0.01772131,-0.08491808,0.023319481,0.033169754,0.061767146,0.010282627,0.010877018,-0.01446513,0.06654828,0.087837964,0.025432685,-0.048261683,0.00888914,0.0048941923,-0.0019750898,0.03353648,-0.017761482,0.10770041,-0.05287986,-0.051217355,-0.005272496,-0.07334053,0.16159616,-0.07678366,-0.055324346,0.019105172,0.029579517,-0.023603652,-0.08557534,0.056228235,0.014456717,0.03102313,-0.07868057,-0.0667436,-0.019209143,0.067454875,0.0042582033,-0.019693045,0.05684485,0.06141946,0.02359172,-0.039407246,-0.020493638,-0.02004224,-0.019970912,-0.009084173,0.018563677,-0.035290346,-0.0028855158,-0.030937044,-0.01686356,-0.048734643,-0.0033747596,-0.017084032,-0.039674103,0.025528291,-0.036985397,0.037757106,-0.08990287,-0.029135395,-0.009306374,-0.042600293,0.043034777,0.026368601,0.040636793,0.109727554,-0.0012725207,-0.033881374,-0.060779516,0.0028504422,-0.014184191,-0.055772547,-0.048546944,0.028845007,-0.018305512,0.018993337,-0.06882936,0.08608907,0.0129803335,0.0038843679,0.014319546,0.036712263,-0.0040331227,0.024100378,-0.08574453,-0.10625768,-0.10331382,0.035241876,-0.038071163,0.02083964,0.09122231,-0.035558417,-0.020520797,-0.07753953,0.05372526,-0.016534356,-0.008374358,0.048739623,-0.011355903,-0.0010154037,0.025177632,-0.11628566,-0.019447055,-0.0090999175,0.08307145,0.016231706,-0.0639073,0.00088891573,-0.10285659,2.488604e-33,0.11882905,-0.017114418,-0.027294291,0.052810635,0.004807263,-0.0067090653,-0.05819577,0.06809298,-0.0414814,-0.043263987,-0.07609785,-0.074265644,0.010215112,-0.017303431,-0.012959612,-0.094298184,-0.030153293,0.05919707,0.02921566,0.030528553,-0.011086077,0.07722334,-0.044167824,0.04913691,0.027040262,0.03931367,-0.016781025,0.00032638616,0.04046198,-0.012424157,-0.05540581,-0.028145025,-0.031876963,-0.036298357,-0.033264954,0.023509227,-0.06293074,-0.027317801,-0.06130809,0.0010569381,0.013263901,-0.013273334,0.018617136,-0.1180327,0.061085485,-0.04546361,-0.096543536,0.039699357,0.01693058,0.04215157,0.050069593,-0.040680453,0.12816894,0.017317332,-0.02200007,-0.0145440465,0.0032499025,0.057218544,0.09327585,0.05845782,0.119310826,0.033392582,-0.005158725,0.0451487,-0.029082624,0.05112215,-0.027529048,0.00063624844,-0.012978666,0.10976866,0.028873459,0.028593248,0.017738055,-0.017402368,0.05409741,-0.07199004,-0.012965783,0.039801702,0.011312942,0.020983083,0.014181137,-0.013850782,-0.022658149,0.007864276,-0.06307837,0.0014949784,0.004056084,-0.019172046,-0.033281818,0.029597638,0.03942214,-0.071604595,-0.019821856,0.010523557,0.032752793,-2.2600818e-33,0.049612843,-0.03588519,0.012807178,-0.019942094,-0.030039694,0.053836334,0.046709485,-0.02739429,-0.035990022,-0.009109131,0.15759125,-0.08897111,-0.027595459,-0.029839108,-2.6188049e-05,0.027398594,-0.01360204,0.0020514966,-0.022477169,0.065607846,-0.01406945,0.06673081,-0.0106458925,0.09082895,0.079403244,0.020967938,0.06615795,0.020174451,0.020592999,0.06448381,-0.074711524,0.013294027,-0.07683841,-0.014768998,-0.046265434,0.06012081,0.025234886,0.011158048,-0.01697375,-0.024210755,0.01291996,0.08217813,0.05851198,0.13097791,0.033390317,0.10508061,-0.07008622,-0.033760052,-0.032522865,-0.013043913,-0.006554293,0.048298437,-0.026716778,0.032237493,-0.028874299,0.0011585993,0.018585343,0.0052955565,-0.021506876,-0.08322943,-0.03149375,-0.059372723,0.007258361,0.08711994,0.072704725,0.111652575,-0.07230589,0.06965023,0.065830775,-0.0014135177,0.06659318,-0.013250091,0.0779097,0.076666586,0.010464023,-0.018794281,0.012971675,0.026828619,0.035921644,0.024318423,-0.009872956,0.017155409,-0.060379766,-0.085005686,-0.03879411,-0.06161141,-0.03680399,0.08472033,-0.019428546,0.046371978,-0.022688705,0.090452835,-0.07031519,-0.009450828,0.055795785,-4.4532907e-08,-0.0019662462,-0.120895065,0.048421673,-0.028412646,0.053592257,-0.050967842,0.0026779785,0.035105646,0.059857197,-0.022725226,-0.042035162,0.06455748,-0.0004906313,-0.02985079,0.013433123,-0.030837514,-0.010462923,0.040633027,-0.024170958,-0.01149032,-0.042982668,0.036041133,-0.07222777,0.039265145,-0.0056300913,-0.084175706,-0.07371954,0.008311535,0.06776961,-0.027001865,0.036195334,0.058674805,-0.03417637,-0.057517562,-0.009531202,0.05520189,-0.02680823,-0.010338706,-0.01043723,-0.02884684,-0.025367765,-0.07424653,-0.013384076,-0.03439571,-0.003196301,-0.032581873,0.04601395,-0.019473229,0.00083257,-0.019647447,0.023179317,-0.004531875,0.040440395,-0.07472836,-0.11988532,-0.01602448,0.036907997,-0.036000643,-0.0136739435,-0.09326837,0.019747207,-0.03248339,0.2176265,0.02013461 +1.14.13.90,"A flavoprotein (FAD) that is active under conditions of low light. Along with EC 1.10.99.3, violaxanthin de-epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle, which is involved in protecting the plant against damage by excess light. It will also epoxidize lutein in some higher-plant species.",384,0.99999994,-0.02839442,-0.04839612,-0.06626826,0.035064828,0.14916302,0.0164065,0.024508549,0.08977863,0.052338444,0.0023640275,0.098418735,0.021557465,-0.037067425,-0.052180838,-0.06950049,0.049958996,-0.05388024,0.011128412,-0.10085357,-0.00019104165,0.017642118,-0.031892627,0.04704073,-0.035944387,-0.017540842,-0.02199765,-0.035703104,0.004432836,0.036340725,-0.028546253,0.07219337,0.08226079,0.041348223,0.03086513,-0.044807203,0.05467754,0.0638672,-0.07219227,-0.004480354,0.012558446,0.0067940643,-0.027384687,0.012918142,-0.036551725,0.020228676,-0.009236389,-0.0033488355,0.02177415,-0.06653331,-0.0232987,0.048625566,-0.0642705,-0.050553523,0.02536551,-0.0022847126,0.01437236,-0.0074924678,-0.048897866,0.008779952,0.008326305,0.075001016,0.011781801,0.020058788,-0.0013380889,0.04135396,-0.031206733,-0.060504787,-0.04934341,0.048910197,-0.037807513,0.0043713804,-0.052527267,-0.017590616,0.043725315,-0.019894041,0.038563147,-0.081277974,-0.022205707,0.047027975,-0.00021357537,0.079129085,-0.011720767,0.05271091,0.07884387,0.088607274,-0.037842955,0.026362708,-0.0045964173,-0.03776345,0.058795325,-0.023521556,0.018289333,-0.0115774255,0.040655278,-0.07332317,0.08017131,0.074783504,-0.1172169,-0.07808217,0.016749723,-0.04593948,-0.0075449697,0.013428082,0.010213883,-0.061983958,-0.124265,-0.03144355,0.061249018,-0.078777984,-0.09103345,-0.03247288,-0.03918426,0.0022496686,-0.050861407,-0.029688733,0.02369593,-0.01533123,-0.03773192,0.002398703,-0.014340646,0.02992961,0.037593015,0.03126248,0.08466054,0.07156278,-0.03825733,-0.05944271,2.0084618e-33,0.0847927,-0.00271024,-0.0613282,-0.058106605,0.013791519,0.0067834407,-0.025033535,-0.0012996506,-0.030770903,-0.03752463,-0.04225273,-0.021101102,0.021865504,-0.03156956,0.05116703,-0.03448344,-0.06575022,-0.011833561,0.09148833,-0.111526996,0.016189337,-0.00012684465,-0.05691639,0.04611513,-0.0031615107,-0.0006267209,-0.034742102,-0.0004084713,0.007467805,0.03248684,0.0032363825,0.0065780734,-0.026338061,0.05873526,-0.0504669,0.11044727,-0.08119494,-0.08215436,-0.057359617,0.09563385,-0.019727727,0.017192993,0.042470425,-0.03098719,0.06958409,-0.020636486,-0.10760172,0.06913494,0.01265856,0.105895214,0.033868514,-0.025718099,0.08864455,0.029653532,-0.06127794,0.06276216,-0.033924334,-0.014357515,-0.03743848,-0.0103773335,0.022628853,0.009736245,-0.0648581,0.064136505,-0.023197597,0.01105601,-0.030163217,-0.07851904,-0.023799729,0.09572879,-0.04343706,-0.04659022,0.07087267,-0.04692695,0.06005422,-0.02612258,-0.033909462,0.030126588,-0.02225339,0.012071302,-0.04322205,-0.022832563,-0.052660737,-0.06784728,-0.025783263,0.025174618,-0.05726361,0.010611613,-0.02390217,-0.009089968,0.10092001,-0.039579574,-0.00077614014,0.006428791,0.024516577,-1.2011812e-33,0.039587222,-0.07108312,0.057757724,0.05683328,0.0553885,0.0764211,0.007573519,0.008124576,0.009401999,-0.00017868202,0.04876515,-0.025264015,-0.05404155,0.009505674,0.014466073,0.020681968,-0.001826723,0.033932477,0.055232972,0.030722156,-0.10646831,0.0723408,0.055817362,0.041440953,0.025671195,-0.018564394,0.04235333,-0.01432465,-0.015214652,4.117593e-06,-0.062524624,-0.016644021,-0.04159808,0.02487423,-0.050873093,0.037063483,-0.008058377,-0.040383495,-0.08506036,0.04466383,-0.013381815,0.016629988,0.014923467,0.04372631,0.03678318,0.061965737,-0.06942098,0.03430656,0.05721025,-0.01990714,0.03468094,0.025963979,0.00023103968,0.081449896,0.036447093,0.038209196,0.049038865,0.07145874,-0.07424436,0.07207536,0.037888885,-0.071932435,0.013286137,0.031125896,0.0694747,0.042448122,0.013680363,0.14468041,-0.0017331144,0.015523232,0.15725288,-0.014063319,0.0008593534,0.039692137,0.010602095,-0.052574888,-0.036219776,0.053733435,-0.043550823,0.016446672,0.01563092,0.023973377,-0.013194531,0.028314577,-0.09318928,-0.115972035,-0.04769146,0.08854207,0.018691441,0.006070691,-0.0339151,0.06456394,-0.017288912,-0.03288238,0.14272244,-3.4954642e-08,-0.034260996,-0.045182142,0.0016306137,-0.0659001,0.09541499,-0.04686067,0.009852808,-0.013090773,0.011190694,-0.061946053,-0.021363433,0.09336812,-0.0009399979,-0.009585727,0.052191306,-0.03425565,0.04122274,0.043701094,-0.041835286,0.008078523,-0.113377064,0.020558473,-0.040273506,-0.030784901,-0.023629159,-0.023136415,0.03457929,0.014978091,0.04813066,0.0035180855,0.035496186,0.04189118,0.041696776,-0.03644676,-0.20029067,0.06681166,-0.0072339904,-0.0870837,-0.062205803,0.06267759,-0.07905926,-0.035048332,-0.0047751716,-0.045285925,0.0018411474,0.025668366,0.07700504,-0.051403396,-0.037806593,-0.012223505,-0.0073209237,-0.02976089,0.013668267,-0.016541846,-0.10668776,-0.004227593,0.01511959,-0.034008734,-0.022866128,-0.06712511,0.0015604841,0.025923638,0.15825562,0.03905563 +1.14.13.91,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.14.13.92,"A flavoprotein (FAD). NADH cannot replace NADPH as coenzyme. In addition to phenylacetone, which is the best substrate found to date, this Baeyer-Villiger monooxygenase can oxidize other aromatic ketones [1-(4-hydroxyphenyl)propan-2-one, 1-(4-hydroxyphenyl)propan-2-one and 3-phenylbutan-2-one], some alipatic ketones (e.g. dodecan-2-one) and sulfides (e.g. 1-methyl-4-(methylsulfanyl)benzene).",384,1.0,-0.0855715,-0.026363159,-0.03606107,-0.02940132,0.06014117,0.0681058,-0.1104156,0.016173387,0.02951839,-0.040146176,0.0025795458,0.022107035,-0.055599358,0.028040245,-0.04054504,0.03565251,-0.00970867,0.034002207,-0.02272547,0.0019373022,-0.024106435,-0.015321715,0.0655775,-0.022527961,0.056849703,0.0036571296,0.012402201,-0.010691619,-0.004084807,-0.04034484,0.035063684,0.036704928,-0.024438635,-0.0007590821,-0.03860299,0.04714728,0.016579177,0.027090332,0.016347893,0.0035926027,-0.032020383,-0.007276297,-0.06670686,-0.019781545,0.011518528,-0.06254144,-0.0394109,0.028649136,0.009480613,0.031751942,-0.03697645,-0.03024812,-0.021472314,0.05127104,0.044460136,-0.013004695,-0.021157136,-0.019062674,-0.032404218,-0.0436799,0.007386836,-0.055063345,-0.0044317814,0.023209736,-0.035967257,-0.052916605,0.040728036,-0.0027402025,0.08481112,-0.05687602,-0.08772976,-0.030203417,-0.03666166,0.021544982,-0.037176494,0.075459816,-0.056452505,-0.07129964,0.06920824,0.013839971,0.03675917,-0.011841238,0.028848471,0.07129805,0.14238064,-0.021378513,-0.047359094,0.03240705,-0.011289954,0.013529434,-0.021417895,0.012394985,0.03156685,0.04427726,-0.12533635,0.05797678,0.06167274,-0.014635141,-0.016742682,0.00651908,-0.017847396,0.068767376,0.021522261,-0.014313034,-0.062690504,-0.026371296,-0.03140864,0.10448965,-0.017723102,-0.046199746,0.012239575,-0.011029553,0.032982487,-0.088203035,-0.03192756,0.068170436,-0.020838557,-0.041841038,-0.03739238,0.042289875,-0.036521584,0.10341658,0.028031982,0.033648163,0.056823332,0.008757395,-0.09301283,2.744029e-33,0.12710306,0.058426864,0.020458674,0.011955455,0.020157278,-0.0063072997,-0.06841271,0.05155018,0.022940079,-0.09568651,-0.01868659,-0.045425672,-0.005585267,-0.025833184,0.081296146,0.005302404,-0.07863844,-0.056559987,0.050977163,-0.063890494,-0.0012938618,-0.0048607653,-0.025274627,0.037404217,0.031259507,-0.07105278,-0.023052543,0.09817919,-0.00257512,0.030864114,0.029464453,-0.06564721,-0.058154035,0.027554503,-0.04445466,0.04290324,-0.14707062,-0.06670657,-0.09476747,0.088358626,-0.02281586,0.0013767168,-0.010089559,-0.02373552,0.059437312,-0.13099785,-0.044908226,0.12142079,0.011938459,0.07688974,0.0101912785,-0.03562111,0.07115715,0.008701063,-0.066433094,0.06376969,-0.012282215,-0.056250375,0.00854602,0.037194766,0.008034138,0.0033545718,-0.017716782,0.08421401,-0.033275105,0.007943797,-0.10978322,-0.029054731,-0.07969281,0.111368455,0.0412484,0.02009556,0.030008737,0.03261634,0.013121866,-0.043200634,0.00015078305,-0.04447183,0.048661463,0.052492473,0.018621037,0.0018975817,-0.0421801,-0.016806016,-0.04255588,0.040451255,0.02891399,-0.051634368,0.07049621,0.029106552,0.04703251,-0.074221484,-0.0045289355,-0.04158515,0.04193876,-3.43439e-33,0.07852972,-0.00651489,0.03755173,-0.022436628,0.026002908,0.06921527,0.097180426,-0.04807106,0.00072959176,-0.07278557,0.032670416,0.00977981,0.03971312,-0.0007942817,0.03782258,0.033374455,-0.020316232,0.019179799,0.0705594,-0.021718616,-0.021994602,0.08204612,-0.016040538,0.025349725,0.052368443,-0.057327803,-0.019282388,0.014236846,0.018622953,0.0961355,-0.014107406,-0.0018254395,-0.033155754,0.03480545,0.0597335,0.10762408,-0.07454073,-0.023651801,-0.03152741,0.07680299,-0.07400267,-0.028529504,-0.059264187,0.04036174,0.100871295,0.014976229,-0.09413705,-0.049515374,0.1157814,-0.10712075,0.015920598,0.034901716,-0.043916762,0.019151209,0.057024635,0.044781145,-0.012273059,0.025618322,0.0636862,-0.027513593,-0.02901207,-0.05668589,-0.003207698,0.00133218,0.059447806,0.042109605,0.001816762,0.045384005,0.026875958,-0.028662309,0.1003691,-0.00966976,0.057287306,0.0415513,0.013834156,-0.087883964,-0.040991455,0.08985064,-0.13333294,-0.0184891,0.082789734,-0.029815668,0.009681316,-0.014318888,-0.07988462,-0.035454504,-0.0067526354,0.010858394,-0.035889473,-0.0121331755,-0.03729975,0.087830454,-0.048786845,0.004716966,0.045413308,-4.932459e-08,0.04936787,-0.04154814,0.024022728,-0.02161803,0.0460211,0.024869537,0.03772205,-0.09973807,0.0026943928,0.007296167,-0.022903884,0.14005998,0.064308755,0.014560442,0.020582153,-0.044855703,-0.06966363,0.0112001635,-0.04015618,-0.0291455,-0.09447965,0.06267768,-0.06297277,0.012551623,-0.054029875,-0.0027160922,0.00072453904,-0.030612733,0.038239326,-0.0390491,0.0288745,0.023441263,0.05038102,-0.040223535,-0.118282266,0.020942388,0.020703156,0.011318378,-0.07329313,0.076109216,-0.010660707,-0.05652602,-0.069560416,0.017207285,0.086723804,-0.039082374,0.07289429,-0.012369602,-0.07674343,0.0077927373,0.069600135,0.02927944,-0.021845242,-0.022160895,-0.031647272,-0.01259161,-0.01408207,-0.046885714,-0.039477997,-0.10431961,0.009316198,0.0037948873,0.1515567,-0.047919992 +1.14.13.93,"A heme-thiolate protein (P-450). Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone [1]. CO inhibits the reaction, but its effects can be reversed by the presence of blue light [1]. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously. Other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase).",384,1.0,-0.076828346,-0.013659926,-0.1089653,0.0122736385,0.15733546,0.07326962,-0.08615663,0.067711085,0.027793625,-0.009894977,0.06740229,-0.014309499,-0.016055247,-0.08160244,-0.051729992,0.0851949,-0.09339583,-0.006648956,-0.018950514,-0.07244621,0.040762722,0.004317784,-0.059687164,0.043672588,0.03385051,-0.044554617,-0.0042786165,-0.029038629,-0.04719921,-0.06615423,-0.04279484,-0.034797594,0.067013256,0.015443126,-0.0070638387,0.08001092,0.003321102,-0.10787181,0.14261155,-0.011711466,0.034934677,-0.03613132,-0.050057862,-0.035430614,-0.025060924,-0.009902444,0.028042575,0.010244481,-0.04221629,-0.02840315,-0.002089233,-0.0043844013,-0.0034652601,0.012515587,-0.092413396,-0.030927284,0.0007004713,0.092142336,0.03187204,0.062998354,-0.008383412,-0.0033210174,0.017337084,0.025163606,-0.012276156,-0.03714095,-0.04634652,-0.05231522,0.013263213,-0.04377669,-0.025018822,-0.06479624,-0.015329849,-0.022271935,0.009292729,0.065056354,-0.035924383,-0.034019917,-0.030406576,-0.035891954,0.050885346,0.0122243725,0.0017228773,0.08824073,0.03209365,-0.05499479,-0.009713773,0.035498623,-0.054218736,0.029645782,0.017690789,0.0046079666,0.01466349,0.013372116,-0.03491734,0.13200033,0.07081985,-0.053194817,0.008007952,-0.065076455,-0.059724145,0.11003345,-0.08241751,-0.07447168,-0.0653603,-0.03360451,0.014071904,0.08016743,0.0082511,0.001458579,-0.043911897,-0.041069124,0.030768938,-0.00042713856,0.02381843,0.12692034,0.03249285,-0.024345396,-0.018951457,-0.07438309,0.022757102,0.003091008,0.04622928,0.074958585,-0.023326151,0.03228288,-0.06751544,3.43215e-33,0.06512619,0.049552448,-0.08443377,-0.06228689,0.0008105513,-0.03019168,-0.08379714,0.026920909,-0.021696886,-0.016821297,-0.005800793,-0.08276936,0.028468775,-0.054236196,0.0066204295,-0.06666723,0.0024868546,-0.014629656,0.03165239,0.033737604,-0.03213734,0.0049925954,-0.10708756,0.029164927,0.0047749276,0.070330285,0.0067183822,0.03269934,-0.014068697,-0.031046644,0.024018105,-0.023269806,-0.08666446,0.03315523,0.0492209,-0.055106573,0.009067237,0.011552395,-0.038727712,0.064093664,-0.028163765,0.07926255,0.019082734,-0.09485622,0.10161862,-0.05835344,-0.03552282,0.10606089,0.09291319,0.059431884,-0.004224965,0.042647783,0.1488624,-0.0050904183,-0.009568685,0.012344163,-0.02628775,-0.014167931,0.0027820722,0.03315244,0.078892685,0.005698017,-0.022994244,-0.020766083,-0.014331231,0.019834746,-0.111986764,-0.061272163,0.012341948,0.065231934,-0.07909833,-0.0307043,0.039093733,-0.04881478,0.049557555,-0.012295608,-0.050230443,0.09881932,-0.008592098,0.041236963,0.018214477,0.03718267,0.058618728,-0.037234016,0.040523995,0.02921261,0.027307784,0.016281009,-0.02686196,0.015121334,0.04955072,-0.057141267,0.0025441053,0.0317408,-0.0030808193,-2.9810366e-33,0.09672928,-0.044926073,0.018571183,-0.057509273,-0.023928331,0.057599414,-0.02759074,0.006298458,0.025071103,-0.017858053,0.09155697,0.021313218,-0.0031515486,-0.021007301,0.059495673,-0.008001425,-0.019835128,0.0785003,-0.011758099,0.031720016,-0.01049203,0.124933876,0.01224513,0.00026012262,0.073372565,0.007925431,-0.0026227222,0.06399596,0.03683545,0.052275326,-0.050159972,0.051231522,-0.040800758,0.0469113,-0.022790018,0.047778048,-0.116360135,-0.016464954,-0.035811733,0.06032581,0.021446709,-0.0017871162,-0.057103198,-0.0018440242,0.07340487,0.06944155,-0.092529185,0.05198359,-0.016898375,0.00024829598,-0.008136691,0.0032090608,-0.027692355,0.00760964,0.061084107,-0.0024769942,-0.02792647,0.051221002,-0.020320278,-0.059604008,-0.01542327,-0.026566934,0.010334883,0.039386462,-0.008086812,0.05306912,-0.04222772,0.07499983,0.006834791,0.03485656,0.13341722,0.054935846,0.010749179,0.040624514,0.028634435,-0.041015,-0.047981128,-0.040893868,-0.07051359,0.018542334,-0.027962081,0.03205534,-0.021740163,-0.08725832,-0.022409426,-0.035473924,-0.07619437,0.0990991,-0.00011203344,0.000527214,-0.027407505,-0.053553957,0.0009902933,0.04368978,0.0743627,-4.5404615e-08,-0.015813168,-0.03520562,0.046466324,-0.036916375,0.027124086,-0.030811876,0.011459139,-0.023636611,0.013567025,-0.043558344,-0.049532495,0.051045667,0.024002558,0.0012069962,-0.01422833,-0.047475483,0.037701864,0.07154021,0.02308607,0.086695254,-0.07345468,-0.052392527,-0.08912047,0.010167588,0.050862093,-0.07508911,0.04956343,-0.03260708,0.038885262,0.021707987,0.049299277,0.038099665,0.10516087,-0.013980802,-0.0465313,0.028333785,-0.03779213,0.01261293,-0.06111292,-0.001023815,-0.011771646,-0.06254911,-0.079624236,-0.0047578234,0.0346196,0.014807819,0.04365203,0.026490062,0.004893289,-0.020291496,0.028162435,-0.06217855,0.032477338,-0.092949905,-0.051791247,-0.03574776,0.04044433,-0.0477656,-0.020967163,-0.031318747,-0.00065717194,0.03356387,0.22181064,-0.071549386 +1.14.13.94,A heme-thiolate protein (P-450). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters [1].,384,1.0,0.0009896823,0.04618967,0.022345696,-0.026277795,0.06170739,0.029865263,0.03399158,0.08678173,-0.0034161706,0.067037106,-0.056179967,-0.011191541,-0.10550381,0.04890736,-0.022368174,0.007550062,-0.07284077,0.005530239,0.008566319,-0.059552573,0.019349078,0.025269354,0.03550853,-0.025231203,-0.07527967,-0.037246145,0.057480916,0.05652821,-0.066014245,-0.014069985,-0.07860014,-0.045748476,0.06840597,-0.042108316,-0.042605482,0.12104037,-0.05195985,-0.045008115,0.051644128,-0.010716048,0.110929355,-0.104649216,-0.072857276,0.0024949268,-0.039456006,0.04907299,0.008680072,-0.0023985743,-0.0021727404,0.071511246,-0.015775979,-0.06789493,0.016000044,0.06877291,-0.082352154,-0.005764545,-0.036548022,-0.0031708134,0.015695775,-0.057146266,-0.0881524,0.044252943,-0.048627228,-0.0139372945,0.06477556,-0.06282196,0.044114668,0.008472141,-0.041940678,-0.015975155,0.053790487,-0.0031643424,-0.04747275,0.036190607,-0.07174072,0.023160575,-0.037158843,-0.026913015,0.05637073,0.010426822,-0.0058924295,0.031711772,0.035037182,0.073472954,-0.003972978,0.011833213,-0.061848063,0.024276411,-0.105635256,0.013643129,-0.060160473,-0.040943608,-0.010328041,0.024609603,-0.06005735,0.038697567,0.030355128,-0.002757888,0.021980029,-0.0011145816,0.016545689,0.012907411,0.024413163,-0.08618986,-0.06251473,0.047463335,-0.022603955,0.035312284,0.052590456,-0.034078624,-0.08859638,-0.02265105,0.0428003,0.043479357,0.02059364,0.07692661,-0.020692853,0.0064912993,0.012562221,-0.058583006,0.015509965,0.022370197,0.069013886,0.051116485,-0.055160772,-0.008278667,-0.08139991,-2.0004067e-33,0.0232191,-0.029886909,0.025771724,0.040259507,-0.0030592342,0.05491483,-0.035991896,0.06550121,-0.04226116,-0.03641455,-0.10849579,-0.1289829,0.03457966,-0.08875363,-0.0015000164,-0.04021673,-0.030693486,0.011780288,0.014381331,0.026749754,-0.10800198,0.061513457,-0.009437877,0.02482767,0.09948229,-0.030669319,-0.026094101,-0.022923296,0.013157124,-0.00913861,0.00614843,-0.025538627,-0.011754356,-0.05492428,-0.024128739,-0.0070030987,0.013762586,-0.0065691546,-0.031212395,0.045289356,0.04549976,-0.08920334,0.015949737,-0.07627808,0.037436794,-0.050872486,-0.07324375,0.019385295,-0.03036991,0.05332867,0.03498915,0.030010698,0.06457587,-0.0070881885,-0.082264505,0.032311134,0.007486234,0.06494377,-0.05178059,0.110874385,0.1324747,0.05721514,0.010193974,-0.0031022532,-0.043986402,-0.016537042,-0.0362127,-0.033121873,-0.04525914,0.1422378,-0.0066220257,0.019789556,0.042935643,-0.07716445,-0.004824142,-0.05560529,-0.011695622,0.14424405,0.04087626,-0.011198428,0.0106960675,0.041778482,-0.07792004,0.01807726,-0.047355067,0.01514698,0.08433989,0.044505347,0.012259666,0.0063988124,0.123415746,-0.102983214,-0.07065017,-0.019316262,0.04177803,4.487937e-34,0.014837576,-0.079038545,0.05470896,-0.0091778245,-0.043104507,0.10331673,0.05626828,-0.018973857,-0.072851226,-0.02420457,0.12523195,-0.04358954,0.008575872,-0.04075952,0.066617295,0.0074062436,-0.10203218,0.010912279,-0.0012975071,-0.030624116,0.018507674,0.016696457,0.031748988,0.041034006,0.015349088,-0.027768875,0.0012708792,0.03847769,0.08286288,0.05798873,-0.061870404,0.022645924,-0.11075944,-0.020801637,0.041354526,-0.03359136,0.008535976,0.02974233,0.0225652,0.02396268,-0.016591903,0.060599208,0.010452769,0.071488306,0.0063555683,0.16619864,-0.01652254,-0.053574234,0.014877579,0.014099835,0.011281365,-0.0034060495,-0.03097644,-0.043825623,-0.0083162105,-0.0528536,-0.026354644,0.006431478,-0.010652447,-0.056719698,-0.07310742,0.015203303,-0.03431265,0.10389673,-0.00917331,-0.021389581,-0.091283835,-0.0015121005,0.026650973,-0.01358197,0.085541815,-0.0037719202,0.063641034,0.042518646,-0.028168911,-0.048003253,0.040819347,0.0041051726,0.028186636,0.003670566,0.011350388,0.025650054,-0.026379952,-0.019500256,-0.023102537,-0.030905271,0.03042816,0.16191447,-0.020416573,0.025134305,-0.016977105,0.056381404,-0.09466934,0.022993375,0.0480483,-2.9314101e-08,-0.04589803,-0.14839204,-0.04691214,-0.05208912,0.029721577,0.08866773,0.0010418359,-0.00056730624,0.019205425,-0.010008387,-0.01526641,0.044571046,0.016336784,0.039442446,0.021174097,-0.007643232,-0.0080906,0.07701439,0.06377374,0.021779059,-0.042162064,0.01953519,-0.0066096564,0.043462995,0.024314357,-0.0359758,-0.0064477725,0.03280686,0.005265176,-0.07443187,-0.009345327,0.07237775,-0.026351573,-0.015101166,0.06019843,0.069105804,-0.03481865,0.03078583,-0.043724,0.0050901817,-0.006975679,-0.07119771,-0.032992672,-0.05087946,0.036662403,-0.019548142,0.06471118,0.04292626,-0.011272223,-0.0721243,-0.05115234,0.044365622,0.048416656,-0.060393766,-0.0843525,-0.03610655,-0.026079072,-0.08124202,0.01614224,-0.051517233,0.031600904,-0.0004931202,0.13457815,-0.034740303 +1.14.13.95,"A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH---hemoprotein reductase, which reduced cytochrome b5 at the expense of NADPH. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid [2].",384,1.0,-0.044341516,-0.016810363,-0.032679968,-0.051357966,0.029889576,0.06883701,-0.05479413,0.12149102,-0.0052733105,-0.034415588,-0.03242847,-0.00866156,-0.08637522,0.004843683,-0.018383913,0.049863268,-0.05161049,-0.0047041527,-0.031959347,-0.11785879,-0.027269071,-0.008048645,0.044481743,0.015715133,-0.023335388,-0.023782896,0.09592837,0.032357022,-0.062200002,-0.06345339,-0.0681749,-0.03197803,0.060774352,-0.050750982,-0.047523033,0.11043987,-0.058514558,-0.026751963,-0.01906461,-0.008573531,0.07627929,-0.028685275,-0.09940982,0.02140441,-0.013986619,-0.041467156,-0.00024646873,0.06173474,-0.004903132,0.012095494,-0.04571481,0.02385767,-0.028143398,-0.005126998,-0.009511562,0.017857276,0.04165736,-0.031056594,0.024378266,-0.103024445,-0.033564303,-0.007973785,0.025195342,-0.038827404,0.014000771,-0.035754442,0.07169169,-0.06617156,-0.012710976,-0.06302003,-0.057120033,-0.05561957,-0.06212033,0.06938886,-0.061503828,0.08874659,-0.06524829,-0.036548313,0.034262482,0.014218343,-0.01009889,-0.0033282896,-0.038092252,0.105238974,0.10020494,0.0036411197,-0.052066408,0.02045426,-0.09426918,-0.042071167,0.0025510094,-0.004757045,-0.011249042,0.0036913597,-0.10031996,0.025819335,0.030034987,0.007465071,-0.012490459,-0.042220745,0.07104162,0.09900096,-0.019096175,-0.05907504,-0.06909461,-0.020624721,0.018190302,0.08881396,0.047730353,-0.07738398,0.018507851,-0.062346153,0.042148888,-0.0566456,-0.014575209,0.17094542,-0.06363792,-0.025642887,-0.032442644,0.025186518,-0.026982145,0.04369617,-0.004869061,0.034457415,-0.023311593,-0.054463256,-0.07625531,3.3081486e-33,0.104403086,0.028864764,0.0011622693,0.030543372,0.008838415,0.034116566,-0.1002801,0.016603723,0.0004897994,-0.044925883,0.038023658,-0.09226155,0.03239843,-0.07791923,-0.016294556,0.0117814075,-0.034434963,0.028760882,0.01973789,0.011202414,-0.054625012,-0.000923307,-0.046621956,0.012898739,0.052668203,0.059894167,-0.018223912,0.007828209,0.011664258,0.034509603,-0.041925527,-0.05170914,-0.03727418,-0.050821885,0.0026627304,-0.014322835,-0.057130236,0.02432659,-0.067367524,0.06895262,0.023856347,0.019477084,0.006231337,-0.051975064,0.067075774,-0.080604106,-0.057078123,0.058040664,0.013995326,0.056388605,0.04003237,-0.055616412,0.14104724,0.031664543,0.005723121,-0.05623082,-0.012090256,0.015399613,-0.017634556,0.06754067,0.16711481,0.08372342,-0.074624896,0.08455072,-0.034988824,0.033079427,-0.06168296,-0.05639464,-0.034596674,0.07900264,0.017041834,0.013871724,0.056697454,0.00030885608,-0.033029623,-0.018510088,-0.0076674893,0.092126444,0.022295482,-0.01531233,-0.00999267,-0.006338115,-0.039473556,-0.024474543,-0.013502231,0.013313209,0.072409205,-0.00040098777,-0.046374395,0.024354374,0.0565098,-0.05964791,-0.019984987,0.010370104,0.013309145,-3.0199045e-33,0.038400758,-0.055377938,0.018954912,-0.0636583,-0.026702974,0.08677363,0.08231806,-0.080229595,-0.010569414,-0.056061294,0.09534397,-0.024071444,0.024194872,-0.00704089,0.0657771,0.009515362,-0.032248184,-0.004706926,7.304243e-05,0.03897599,-0.0015067059,0.06869465,0.05795939,0.056191526,0.032373834,0.035896752,-0.04556833,-0.014929458,0.06422821,1.645107e-05,-0.06354411,0.047742557,-0.09287542,-0.046504356,-0.05768751,0.01056101,-0.0034461722,0.0426048,0.022212258,0.05179376,-0.045106016,0.06988944,-0.0037864512,0.027829334,0.021499991,0.10766596,0.008127602,-0.025768505,0.05026383,-0.044845372,0.054023977,0.009344002,-0.039311808,0.055257197,-0.02351708,0.04390118,-0.048583936,0.07287712,5.1848987e-05,-0.107677154,-0.10173029,0.021149145,0.04085487,0.04746601,0.0014357597,0.06547718,-0.039486453,0.070932105,0.03765139,-0.03660608,0.007986926,0.031835996,0.10524817,0.09554849,0.008514841,0.005012649,-0.003995948,0.019983914,0.06165817,-0.018602755,-0.04491731,0.010526387,-0.067144096,-0.05534646,-0.0053885994,-0.072414756,-0.07658286,0.061338186,0.03726859,0.010217527,-0.031705853,0.022785658,-0.07430564,0.053746514,0.018769413,-4.057598e-08,0.051753707,-0.067946784,-0.019906428,0.02941057,0.05984747,-0.010870197,0.045494787,-0.016433112,0.06311752,0.00195405,0.012055412,0.10428997,0.007809344,-0.0038422607,0.015346053,0.031842973,-0.0137338955,0.03238033,0.0313039,-0.03418072,-0.061003283,-0.015602508,-0.038192015,0.039476503,0.032261822,-0.048551135,-0.00540605,-0.06634287,0.047488768,-0.046774287,0.035620816,0.026745852,-0.018569047,-0.020001303,0.067764215,0.019622765,-0.07426718,0.044054806,-0.01863292,0.06162717,-0.005248928,-0.071668796,-0.07466081,-0.0002761329,0.051893,-0.028089471,0.024710545,0.027857913,-0.036271095,-0.018387383,-0.08931475,-0.003663718,0.058164824,-0.072287984,-0.08018452,0.046216603,0.086582795,-0.07131763,-0.05301953,-0.089215025,0.044251315,0.026304983,0.15429287,-0.041607417 +1.14.13.96,"A heme-thiolate protein (P-450). This is the key enzyme in the biosynthesis of the bile acid cholic acid (3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid [3]. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent [1].",384,0.99999994,-0.019336794,-0.076948896,-0.10507197,-0.05643582,0.0046530175,0.06698917,-0.07148238,0.10105036,-0.008888074,-0.03150275,-0.016071355,0.003468711,-0.113063745,-0.0041833073,-0.020480685,0.033207875,-0.082006395,0.021429446,-0.017945873,-0.12654474,0.02714154,-0.004479062,0.027113985,0.018086948,0.00097118685,-0.019150931,0.1400659,-0.007897634,-0.016385548,-0.07322882,-0.038420383,-0.06148349,0.102506176,-0.06267136,-0.007350682,0.09161984,-0.07198781,-0.05806561,0.06737001,0.016869508,0.090945706,-0.024215015,-0.07770118,-0.01788545,-0.020584268,-0.012952344,-0.0014331695,0.012318955,-0.006701853,0.045068737,-0.0637385,0.0099369325,-0.057310957,0.00890009,-0.02046994,0.028336527,0.013486173,-0.045124944,0.04124681,-0.04074872,-0.003692794,0.032595076,0.030601466,-0.03555385,-0.014288328,-0.059272047,0.048057638,-0.076072745,0.01921672,-0.09741841,-0.0360052,-0.057329327,-0.055694524,0.036061924,-0.062184844,0.062204197,-0.05840963,-0.02912883,0.026349284,-0.018147374,0.0012252976,-0.01835737,-0.019484073,0.1407564,0.07911492,-0.025491329,-0.038509414,0.019726709,-0.034598976,-0.032569814,0.005561899,0.00025094638,-0.046978127,-0.027938873,-0.03622389,0.0115558,0.054190308,-0.041079983,0.013248326,-0.017462702,0.07293824,0.08258517,-0.023067627,-0.11825355,-0.044073384,-0.008723582,-0.016897088,0.08148462,0.074108206,-0.029012674,-0.00954324,-0.017539978,0.09802918,-0.034449436,-0.029340671,0.16728248,-0.051368788,-0.044426214,0.03457113,0.0524481,-0.006475759,0.015830848,0.028168248,0.05481859,-0.060062774,-0.03722169,-0.04580216,1.7909127e-33,0.08060789,0.01283597,-0.0023944636,-0.017085165,-0.009325449,-0.01742011,-0.08157792,-0.013405203,-0.019450556,-0.001754058,0.024823934,-0.08764826,0.019511446,-0.039515648,-0.03648224,0.007765695,-0.04350804,0.044202477,0.019583583,0.04433504,-0.072834834,0.03755191,-0.07206921,0.027347831,0.06917753,0.051009268,-0.008166266,0.02152649,0.014713176,0.028934753,-0.033697806,-0.040060647,-0.016341893,-0.011876893,-0.0009920797,-0.03080194,-0.06252109,0.03210422,-0.050200194,0.062802516,0.10000567,-0.037351873,0.020287251,-0.042989787,0.04933215,-0.021685867,-0.029117204,0.04952157,0.031905722,0.027817138,0.043415654,-0.019887,0.1284877,0.061755836,-0.003611702,-0.056484967,-0.02817952,0.034184586,0.04191032,0.06974048,0.119479775,0.059889227,-0.055520765,0.052320946,0.0013165075,0.013283314,-0.07146347,-0.023069892,-0.031329278,0.07084381,-0.028232137,-0.0017401595,0.004577721,-0.0035065636,-0.04602544,-0.03522089,-0.025824863,0.06918386,-0.005947409,-0.038481157,0.0031522997,0.04286653,-0.020811835,-0.044762325,-0.062723376,0.00017321356,-0.007702298,-0.029218987,-0.072922334,-0.0011741485,0.010711034,-0.06918417,-0.025066392,0.0635743,0.026683126,-3.178921e-33,0.0392546,-0.0831083,0.02684078,-0.06185667,-0.020992711,0.06516543,0.06376937,-0.023846498,0.0076749185,-0.00082264835,0.08768366,-0.025542494,0.02458311,-0.04243006,0.04411465,0.07323303,0.010787993,0.06442885,0.0023150365,0.03806883,-0.0031630357,0.09941636,0.022456931,0.07573764,0.042124353,0.06439936,-0.048771825,-0.020794569,0.0751139,0.08960291,-0.022010408,0.0017392534,-0.06191715,-0.014700822,-0.09851632,0.008023298,-0.017724104,0.007515997,0.028764207,0.045480967,-0.0209419,0.047147226,0.0708004,0.02580946,0.031876978,0.070003696,0.027096787,-0.065618195,0.0067625367,-0.022824354,0.028042134,0.007174339,-0.0151115665,0.037273366,0.00065416313,0.07822638,-0.054377843,0.047756854,-0.008053377,-0.1310399,-0.104977205,0.00089205016,0.055104967,0.035024676,-0.02245643,0.06924781,-0.07780669,0.0249175,0.020987906,-0.040808335,0.01956509,0.071094915,0.04645636,0.120646864,0.017681768,-0.023759494,-0.023060715,-0.012590303,0.01827244,-0.019891508,-0.02639511,0.008283175,-0.040357836,-0.0721282,-0.03869238,-0.07111653,-0.043233212,0.09778297,0.05341096,0.018219525,-0.01621985,-0.022163356,-0.118680105,0.012439902,0.03549969,-4.5385136e-08,0.029122243,-0.14484203,-0.037644546,0.015064059,-0.020338465,-0.006898742,0.020746998,-0.009026621,0.034787323,-0.04260393,-0.01038525,0.09481007,-0.028711498,-0.0059934515,-0.015550823,0.032546718,-0.029305046,0.052381027,0.02169229,-0.021748519,-0.0435879,0.009788109,0.008979286,0.021326836,0.01660424,-0.03854371,-0.04601794,-0.039728872,0.008288096,-0.036746584,0.037569456,0.03447441,-0.0489388,-0.03770986,0.029610151,0.034772173,-0.038653444,0.0017722395,0.00858767,0.060853444,0.030751774,-0.073627256,-0.09954962,0.0015519075,0.030794656,-0.010639183,-0.0037183496,0.040468615,-0.010155732,-0.019010633,-0.06859148,-0.012893283,0.034352474,-0.06490243,-0.04447365,0.011126064,0.03988612,-0.08424666,-0.054416776,-0.04568445,0.024238134,0.044896536,0.24816963,-0.06401144 +1.14.13.97,"A heme-thiolate protein (P-450). Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid [5].",384,1.0,0.030275077,-0.05595686,-0.042793956,-0.036464017,0.03552743,0.06385668,-0.058394514,0.08548362,-0.011420662,-0.004146652,0.021736315,0.026956089,-0.06859594,0.060295995,-0.0048849946,0.075580016,0.0061696153,0.0074542756,0.008207614,-0.099370055,-0.056327153,-0.024860198,0.0010811507,0.033109434,-0.03676841,-0.027861776,0.074263774,0.0047179665,-0.10449277,-0.0785124,-0.052173235,-0.03342765,0.0989821,-0.061793193,-0.056609422,0.030402575,-0.07357972,-0.0028217277,0.04152388,-0.050804567,0.058846846,-0.07019209,-0.06159195,-0.01424864,-0.052824,-0.057708796,0.011221474,-0.011930535,0.05165677,0.05238744,-0.06059819,0.017810533,-0.038290754,0.050073594,-0.07337968,0.06495158,-0.04285099,-0.024882248,0.051306006,-0.043062825,-0.07665414,0.023629732,0.010486299,-0.03376821,0.034844615,-0.030513475,0.061667044,-0.042265728,0.031877752,-0.034033682,0.008152422,-0.05253305,-0.018300233,0.015304553,-0.067535855,0.07848496,-0.05038057,-0.05008641,0.051500868,-0.048218857,-0.02314903,0.0017586525,-0.048851907,0.12148926,0.119062826,-0.030610546,-0.07446433,0.01537417,-0.07965872,-0.027509386,0.02048735,0.0035393604,-0.03898088,-0.044367023,-0.024745105,-0.00495815,0.03772769,0.037937067,-0.04529465,-0.01993188,0.056500457,0.05311684,0.0024191423,-0.10001326,-0.014211939,-0.0026057416,-0.020429311,0.04165617,0.08382469,-0.054001868,0.012521752,-0.045589413,0.026281785,-0.041880462,0.023661297,0.14121884,0.011380419,-0.047801264,-0.041605595,0.033243094,-0.017871508,0.030585071,0.05517334,-0.0059569324,-0.0263953,-0.0011105178,-0.007766077,5.8327754e-33,0.08690336,0.032714862,-0.032698512,0.040659018,0.011247242,0.018623566,-0.09849531,0.03872448,-0.010734111,-0.011028003,-0.004695061,-0.034832533,0.023030246,-0.032182444,-0.013698343,0.011492839,-0.032571048,0.010093131,0.08117542,0.021339174,-0.088617876,0.047900178,-0.04327321,-0.019251144,0.027960796,0.043746687,-0.0147669865,-0.026740965,-0.022562595,0.05640012,-0.027955936,-0.029490722,-0.061365712,-0.028623575,-0.009628572,0.016849322,-0.052957628,-0.011313304,-0.040579773,0.018981699,0.07964734,-0.016178278,0.01246188,0.00026601748,0.039274335,-0.032383095,-0.05785917,0.031315953,-0.029884867,0.049259026,0.036782283,-0.103936695,0.08151529,0.022778163,-0.02851632,-0.04193049,0.030972058,0.014656796,0.0035621317,0.07452842,0.12441878,0.101373345,-0.094990976,0.06282219,0.0137408255,-0.03818641,-0.07401681,-0.040399957,-0.058283187,0.03031613,0.0012079289,-0.023207476,0.03679728,0.009199492,-0.05677009,-0.045628812,-0.039016556,0.10925355,0.032794267,0.014947013,0.020004597,-0.013074062,-0.042096492,-0.0097288815,-0.050315607,0.053624764,0.066734105,-0.029729018,-0.04056545,-0.0562904,0.031550605,-0.076272056,0.001710399,0.033235814,0.030115625,-5.7589408e-33,0.01943052,-0.08537836,0.0627597,-0.04141096,-0.03884771,0.09138857,0.06496875,-0.048771087,0.009107429,-0.039633326,0.11838551,-0.07007833,-0.01218227,-0.0042917235,0.06988354,0.04611405,-0.045972195,-0.019805353,-0.019306384,0.0064275367,-0.06451041,0.06328196,-0.015581348,0.12758328,0.083357796,0.05718379,-0.007369555,-0.025300825,0.082088046,0.071355335,-0.053381525,0.070944905,-0.056787435,-0.045137335,-0.0077020223,0.00084395707,-0.00900573,0.01168615,-0.024054036,0.034101818,-0.03859008,0.07878451,0.064544916,0.042417407,0.0095038945,0.13219541,-0.025883391,-0.05910433,-0.024050698,-0.00936253,0.055164,-0.04020668,-0.046790466,0.010210013,-0.008992975,0.06600975,-0.061749864,-0.0040950114,-0.049695026,-0.15170543,-0.09874421,0.039605964,-0.013155724,0.02560159,-0.031342994,0.04067591,-0.06469913,-0.03550872,0.02034155,-0.049396235,0.0079359915,0.02928359,0.10132446,0.080022484,0.03153017,0.041938245,0.0072407336,0.019105107,0.036447644,-0.031857286,-0.027174609,-0.0043496448,-0.039516944,-0.061993,0.024992954,-0.07190792,-0.090864815,0.112546,0.029422477,-0.009422412,0.0013743298,0.034727164,-0.085906945,0.022470692,0.047668032,-4.1293923e-08,0.021496741,-0.07786747,-0.022458784,0.025608134,0.02298103,0.014462634,0.032825645,-0.030707324,0.06576831,0.0030682986,-0.07260429,0.09609829,-0.023258306,0.01018952,-0.050823603,0.069738805,0.006730389,0.024213154,0.034671754,0.013054324,-0.06407114,0.0056899725,0.008447689,0.019306343,0.018401094,-0.061742943,0.028529013,-0.040440347,0.032392386,-0.020809473,0.05317341,0.014219324,-0.06619455,0.009214418,0.090904765,0.021302165,0.022910401,-0.02860987,-0.016185252,0.085413925,0.017076358,-0.015539279,-0.13379954,-0.034254584,0.024288736,-0.064672425,0.009831877,0.053583983,-0.055245765,-0.022845516,-0.07389424,-0.0017852262,0.037801877,-0.06538234,-0.04402054,0.008620692,0.08517082,-0.08924995,-0.044215016,-0.06662332,0.05591309,0.042126358,0.1690405,-0.028227841 +1.14.13.98,"A heme-thiolate protein (P-450). The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood---brain barrier whereas cholesterol cannot [3].",384,1.0,-0.056217287,-0.026644003,-0.0355822,-0.035653435,-0.02034773,0.0073145675,-0.02509288,0.10672642,-0.024905402,-0.01704539,-0.058549967,0.033191882,-0.08514015,-0.028780146,0.007176797,0.052218795,-0.041808963,-0.011684324,-0.016727373,-0.047054946,-0.0017861729,0.013550964,-0.05154356,0.030990602,-0.07907038,0.04146322,0.08664045,-0.038569957,-0.049629133,-0.07104066,0.035919305,-0.05009781,-0.016978996,-0.042164933,-0.034316286,0.07073583,-0.07559947,-0.045474898,-0.002585388,-0.05654626,0.11650891,-0.09876582,-0.07443519,0.00010126296,-0.00094650575,-0.035713796,-0.0265219,0.054821618,0.016072249,0.024158709,-0.067427956,-0.041061986,-0.06273111,0.039837237,-0.04341251,0.0060186936,-0.00063076295,0.04750071,-0.027727365,0.029286606,-0.07856964,0.028373387,-0.0033974217,-0.013242307,0.009173496,-0.068799846,0.02212275,-0.059047278,-0.0418502,-0.013475924,0.00010082173,-0.05886891,-0.029181259,0.0037058326,-0.012952231,0.0363121,-0.088044874,-0.07340877,0.041116197,-0.0536722,0.05430491,-0.017232599,-0.0035854217,0.12025137,0.070843846,-0.007454755,-0.03507089,0.08899887,-0.039039217,-0.009648922,0.01675733,-0.00084065454,-0.024303269,0.017539224,-0.06492661,0.009046808,0.0036855142,-0.019416751,-0.0048819873,-0.0078018894,0.03349855,0.038987927,-0.019967407,-0.061228424,-0.09006205,0.027889205,0.040584352,0.011174379,0.031605262,-0.0024711078,-0.033052295,-0.028496196,0.059998926,-0.0028567372,-0.004190184,0.10143456,-0.013132159,0.025676487,-0.0049991724,-0.07268094,0.024378011,-0.007502085,0.04988814,-0.017994829,-0.047866296,0.004082278,-0.022261316,2.507776e-33,0.038622677,-0.053111084,-0.011420077,0.019860845,-0.026097365,0.0397399,-0.048022203,0.06225624,0.020251712,0.0032997935,0.0075693685,-0.14013797,0.03594783,0.022302046,-0.014327253,-0.035626486,-0.03597217,0.0774833,0.041934885,0.0069748247,-0.06513071,0.03990796,-0.051606774,0.032949723,-0.02745793,0.05044474,-0.018994005,0.032947958,0.026489198,0.03141865,-0.08636455,-0.047926504,-0.06873282,-0.077684045,0.01911426,0.03504507,-0.031721584,0.008285666,-0.05816565,0.05577215,0.024701418,-0.012511135,0.008346321,-0.07688875,0.050229285,0.020097483,-0.013038122,0.0126195615,-0.0007734102,-0.0054094656,0.009406446,-0.05055188,0.06040386,0.052807093,0.009785417,0.023553979,0.02112012,0.07845025,0.07304925,0.052015428,0.10986397,0.12605698,-0.08072579,-0.006217797,-0.025975564,0.015267656,-0.04130211,-0.017153641,-0.046992827,0.12831949,0.05086502,0.035931185,0.0149629535,-0.042813573,0.031508382,-0.036370803,-0.0077170716,0.10891054,0.054157156,-0.031001199,0.05499205,0.007920709,-0.012075614,-0.049984194,0.004138389,0.069888264,0.057255883,0.015476969,-0.03920229,-0.004017098,0.07766951,-0.12988584,0.00659603,-0.049812436,-0.021894798,-2.7072465e-33,-0.014645559,-0.0601118,0.018222952,-0.062419835,0.0012208374,0.062838845,0.07135791,0.013830295,0.023521394,-0.031801064,0.081463665,0.01155482,0.010004732,-0.050289143,0.07813518,0.0193696,-0.10383768,-0.033782613,-0.009278856,-0.020178707,-0.004402562,0.049252708,0.026874628,0.15724124,0.012107363,0.016412515,-0.0053727785,0.010213981,0.15445727,0.06827281,-0.055003613,0.0063034953,-0.054078158,-0.020457134,-0.07999375,0.05093178,-0.025415638,0.0078018988,-0.031425674,-0.0073500257,-0.0553882,0.036904175,0.099925496,-0.007634297,0.0032017766,0.11076821,-0.04719463,-0.020723684,-0.017863631,0.00023564651,0.027721008,0.04942166,-0.03091238,0.024105545,-0.045534894,-0.014862808,-0.0035250508,0.03388387,0.013727818,-0.12931015,-0.08173151,-0.02784103,0.025293965,0.030857632,0.02339765,0.08296404,-0.051519424,0.044157863,0.030365149,0.008162649,0.026122393,0.07891119,0.023767482,0.053994913,0.033478856,-0.004868175,0.0015789536,0.0006608196,0.037369374,-0.005876363,-0.013005272,0.029075053,-0.058259707,-0.105412,0.005423984,-0.09298836,-0.075305454,0.026699318,0.046199836,0.03995095,-0.02854647,0.02355032,-0.098947495,0.040167686,0.03416262,-4.5034028e-08,-0.0051184413,-0.14812444,0.010045282,0.031600736,-0.014619897,-0.019106224,0.04714183,0.056423116,0.08004446,0.004033791,0.016782587,0.10428018,-0.01592191,0.04354114,-0.013690325,0.02863132,-0.008548809,0.04894093,0.037698906,-0.048104573,0.01621674,0.0029587073,0.004328037,0.043531854,-0.0030155533,-0.012591764,-0.03541258,-0.063395604,0.013419292,-0.04882544,0.03304415,0.036512833,-0.03035827,0.052170616,0.072396204,0.0333736,-0.024539053,0.026212927,-0.032840736,0.06251103,-0.020222891,-0.061810374,-0.08812694,0.00093771896,0.03894571,-0.035692237,-0.0050272886,0.07275685,-0.018192505,-0.052758187,-0.033822253,0.031689752,0.0095727155,-0.091914445,-0.076978005,-0.01641343,0.0002060329,-0.058399554,-0.046814688,-0.10093622,0.071798936,0.044696666,0.2707722,0.031102993 +1.14.13.99,"A heme-thiolate protein (P-450) that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24R)-cholest-5-ene-3beta,24-diol as substrate.",384,1.0,-0.027947756,-0.046648458,-0.02329291,-0.027852787,0.056437556,-0.00102331,0.045597643,0.1130938,-0.004808144,0.00014883956,-0.008314588,-0.047672417,-0.08330382,0.035649907,-0.032989237,0.008108096,-0.06447005,0.0061486373,0.014232205,-0.13877727,0.007997723,0.03916941,-4.9240083e-05,-0.033595487,-0.024678627,-0.029830704,0.11840905,0.045225374,-0.018185081,-0.07144861,-0.058585573,-0.005615755,0.053864278,-0.008423412,-0.03971163,0.061589662,-0.09368943,-0.03745347,-0.0033252947,-0.070030354,0.111490704,-0.017753057,-0.050134584,0.023027144,-0.04371537,-0.053371698,-0.052054558,0.044236805,-0.00883173,0.039749146,-0.04360548,-0.06022798,-0.02049898,0.046805155,-0.00012376587,0.029906256,0.009255468,-0.029617129,0.043100014,-0.08764581,-0.026155962,0.003293708,0.03492269,-0.032485973,0.020394104,-0.0014563854,0.066707805,-0.031163318,-0.041617315,-0.094131395,0.0059516453,-0.06290635,-0.050815564,0.0692985,-0.045491204,0.08554132,-0.03975084,-0.017374327,-0.0010375842,0.02493476,0.004882072,0.06378112,0.09069823,0.08238924,0.07206335,-0.029872082,-0.03975733,0.038123213,-0.06117405,-0.07970902,-0.032172102,0.027692683,-0.11400322,-0.01211028,-0.07323608,0.01029021,-0.005301243,-0.019423373,-0.026066286,0.008432269,0.047781337,0.043871112,0.0002218079,-0.07417242,-0.10411317,0.008228938,0.018092513,0.04983645,0.06313084,-0.041067306,-0.035087183,-0.023444567,0.05013671,-0.053654023,0.025539435,0.13347617,-0.04560681,-0.0155531755,0.110183544,0.009703258,-0.05365477,0.06947563,0.026088882,0.00427129,-0.062258635,0.055666786,-0.038805373,-1.932583e-34,0.05638862,-0.010076007,0.010232853,0.03643532,0.04101828,0.028514298,-0.036490235,0.07185257,-0.026981376,-0.11464141,-0.010849537,-0.08179177,0.022580747,-0.03402456,0.0040716836,-0.013320903,0.009164545,0.009397466,0.036254805,-0.0032478522,-0.0703373,0.03038613,-0.053464,0.015358666,0.036612686,0.048620585,0.00096418295,0.007487082,0.1005837,0.014822582,-0.05766511,0.022841081,0.03103206,-0.017287806,-0.012059884,0.048386373,-0.026367212,0.037155062,-0.09474206,0.061006404,0.08979386,-0.033193313,0.028324025,-0.1155284,0.01919947,-0.09433599,-0.09362756,0.013518714,-0.027462441,0.018502492,0.053990256,-0.009395234,0.08840792,0.014008365,-0.007412404,-0.0087832995,-0.033625998,0.041371625,0.03179834,0.017617133,0.13304113,0.036768593,-0.02365989,0.08855347,-0.007892591,0.070285544,-0.12812626,-0.040236704,-0.08310651,0.09745951,-0.04392747,0.031347316,0.07724968,-0.041575953,-0.009592345,-0.04687457,-0.033435605,0.054963905,0.00726342,-0.020486072,0.020272503,0.002670937,-0.051826183,-0.054561153,-0.031329684,-0.03185558,0.026205879,0.02649291,-0.034763005,-0.033648327,0.042551152,-0.031359904,-0.076855645,0.038424965,-0.020985955,-1.3597448e-33,0.020475347,-0.07669662,0.07752793,-0.012720763,-0.00796381,0.07352597,0.0686252,-0.021565732,0.06448867,0.008858887,0.11448117,-0.024718303,-0.0069677695,-0.08798583,0.08018015,0.054926515,-0.041743357,0.04923863,0.026052807,0.0037928282,-0.027640333,0.054365642,0.02337729,0.061068695,-0.0040803915,0.042428497,0.009609482,-0.031873655,-0.0011548181,0.03858899,-0.05474711,0.035210885,-0.039135534,-0.00021150064,-0.09136538,-0.029425299,0.006561315,-0.069973245,-0.018954303,0.015166128,-0.052261274,0.063351706,0.06465227,0.11500035,0.0120871775,0.11201297,-0.014916016,-0.029029476,-0.004241438,-0.009042062,0.018855408,-0.0061417795,-0.05868186,0.019366233,-0.043073844,0.050438005,-0.0171115,0.060310815,0.018164124,-0.062031757,-0.05708615,-0.00043623344,-0.0056194346,0.07436813,0.039284386,0.05154106,-0.061653603,0.07710213,0.03403403,0.004141226,0.014184793,0.020309666,-0.0213489,0.06814019,0.02491424,-0.014263202,-0.014184347,0.038225863,0.021634182,-0.011250183,-0.024930961,-0.04309973,-0.03692624,-0.024853548,0.023501502,-0.12343662,-0.06589979,0.09594999,0.050693363,0.03020705,-0.05822341,0.03907267,-0.07555062,0.020349829,0.057308983,-3.9793505e-08,0.08558483,-0.13537991,-0.08825144,0.018865453,-0.036673307,-0.009240586,0.032856937,0.028216988,0.04810803,0.034479458,-0.019051328,0.057611626,-0.064508066,-0.034716763,0.044013057,0.06155242,-0.011923191,0.012301057,0.017202774,-0.0070715365,-0.04185283,0.005577837,0.021404652,0.022186253,-0.015042666,-0.0129724825,-0.013864479,0.011897244,-0.04801569,-0.025737463,-0.0057317093,0.06077373,-0.054253817,-0.0033858535,0.0109751765,0.058379516,-0.02663211,0.006857405,-0.022190746,0.058067583,0.02168791,-0.057228476,-0.06899693,-0.07459757,0.0041083964,-0.011114743,0.03899957,0.07038828,-0.017453698,-0.031913687,-0.12853588,-0.0016108055,0.008565297,-0.016293142,-0.087969884,-0.014042394,0.042229556,-0.037452135,-0.01697581,-0.08771066,0.029059077,0.02916472,0.18552387,-0.0056710984 +1.14.13.100,"A heme-thiolate protein (P-450). Unlike EC 1.14.13.99, 24-hydroxycholesterol 7alpha-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent [2]. ",384,1.0,-0.073115304,0.0062353495,-0.057309058,-0.0062888367,0.06316105,0.010494547,-0.03227954,0.14356327,-0.0056128255,-0.043915644,-0.05952669,0.01809216,-0.08566713,0.013281088,0.010103723,-0.001809474,-0.052933685,-0.0032982621,0.03434887,-0.06283406,0.016573133,0.025717298,0.00836749,0.061838396,-0.065534756,0.025367657,0.057342876,0.07262358,-0.08975942,-0.096468516,0.0012967051,-0.033479508,0.0386051,-0.010544303,-0.017984482,0.08698727,-0.042273015,-0.043027308,0.007159887,-0.017507553,0.09731744,-0.087574884,-0.04721611,0.010594163,-0.044399057,-0.060137607,-0.031137535,0.02671974,0.004177049,0.07328108,-0.033833414,-0.052995566,-0.055018388,0.052411225,0.0068298,-0.020703427,0.019050712,0.0052533215,-0.033798967,-0.010313725,-0.05223567,0.01212321,-0.0062024384,0.017500974,-0.028017782,-0.057574406,0.0075625516,-0.061453473,-0.026873104,-0.09276243,0.006045998,-0.04109412,-0.0065240976,0.06844903,-0.067861855,0.0778324,-0.06828026,-0.0637138,0.01929785,-0.03208956,0.031028574,0.010480397,-0.038169745,0.096887976,0.05996743,-0.06182395,-0.04689473,0.036606736,-0.009743532,-0.018496664,0.06060644,0.0054685976,-0.006899407,0.033109963,-0.049203508,0.016289616,0.04044224,-0.014496316,-0.064683154,0.016614823,0.033793807,0.084444605,-0.049087793,-0.057815205,-0.07431112,-0.00825179,-0.0075976346,0.038183827,-0.001254203,-0.039640706,-0.027794717,-0.044041153,0.06698933,-0.0131999515,0.03820867,0.07566391,-0.014079765,-0.023939727,-0.058966745,-0.043804478,-0.017259492,-0.0063413586,0.051054917,0.028495274,-0.037821252,-0.027809432,-0.0579911,2.2787202e-33,0.040987153,-0.024009919,0.012911195,0.03410815,-0.035756875,0.05570339,-0.077048376,0.06667155,0.019706747,-0.01875149,-0.025696805,-0.07893328,0.061517674,0.009225755,-0.023653397,-0.056726918,-0.059531536,0.100474365,0.0297283,0.033252586,-0.03558606,0.03650772,-0.073695265,0.0216078,-0.027000293,0.062479123,-0.018822521,-0.0052599986,-0.001443087,0.03423436,-0.060134605,-0.056382086,-0.036874652,-0.045455042,0.015962368,0.0003727118,-0.064098716,0.019531405,-0.07952979,0.035328507,-0.0027649158,-0.017412087,0.009920618,-0.09188407,0.046973355,-0.0056325365,-0.06169896,0.08793417,0.020058487,0.026777023,0.03684151,-0.037345946,0.056390513,0.03728147,0.0008800588,0.06788906,-0.031461857,0.058529373,0.048234273,0.031425618,0.14973961,0.08318978,-0.06749979,-0.009311944,-0.033616163,0.05536683,-0.02608931,-0.05279073,-0.042725172,0.16564079,0.042051587,0.07618311,0.039029412,-0.016351948,-0.003288404,-0.024898386,-0.015148071,0.09942776,0.043865968,0.0077181095,0.04438446,-0.039419774,-0.023663092,-0.03989686,-0.020048559,0.033856925,0.04346557,0.032660782,-0.00060665736,0.03336757,0.08974928,-0.1442052,-0.031121485,-0.01664525,-0.056662675,-2.2698981e-33,0.04003434,-0.062091075,0.029438948,-0.0968599,0.0018183147,0.07503736,0.06395375,0.004470271,-0.029262068,0.008143612,0.1012642,0.016123708,-0.0022717605,-0.067335,0.0813364,0.022273287,-0.103623904,-0.012228742,0.04724641,0.0378869,-0.028542645,-0.00090000144,-0.010533477,0.12371163,0.05752915,0.046718773,-0.056169067,-0.0029383905,0.1053958,0.0578907,-0.042274076,0.015274497,-0.014890234,-0.020988371,-0.06738015,0.080814295,-0.037179004,-0.010732457,0.015864315,0.023532435,-0.06607073,0.031516626,0.06061189,-0.015678696,0.008710228,0.07997682,-0.06419378,-0.04101662,0.030383844,-0.03502801,0.00788438,0.046813525,-0.03947632,0.024465473,-0.05449616,-0.0071432767,-0.08215922,0.047090597,-0.0011821855,-0.09997869,-0.031093642,-0.052987877,-0.014498889,0.04937813,-0.00998178,0.04804301,-0.06330387,-0.017553343,0.0146050155,0.02528199,0.033210333,0.007610594,0.05298061,0.032327563,0.0604649,-0.06395497,0.011373418,0.012757545,-0.021994717,0.032605715,-0.019644791,0.020596512,-0.050058775,-0.0993603,-0.032320186,-0.05604456,-0.03381726,0.077660955,0.029993398,0.04389402,-0.013578116,0.05087174,-0.0905807,0.044482905,0.0669532,-4.462512e-08,-0.019464074,-0.12809533,0.05520996,0.03493529,-0.006692052,-0.0040714224,0.054812137,-0.005446533,0.06059467,0.0060317796,0.05021471,0.09041483,0.009775049,0.019886877,0.009889585,-0.019967092,-0.013471305,0.047167704,0.037517976,0.01564019,0.0029490888,0.005432556,-0.0024619189,-0.012553133,0.025842873,-0.028017225,-0.03957368,-0.06261824,0.034569014,-0.0033226465,0.019849835,0.047172897,-0.017833622,-0.007167371,0.0105756605,0.070409246,-0.04425385,0.019480836,-0.065512136,0.028868496,-0.022915611,-0.077023014,-0.09487041,0.010547036,0.056569785,-0.02916189,-0.0028174208,0.08194522,-0.019167246,-0.042420134,-0.02802971,0.011742262,0.023221137,-0.08972973,-0.06778526,0.024747893,0.0063856556,-0.07147285,-0.043236624,-0.07050702,0.075892955,0.008458204,0.27177984,0.01864752 +1.14.14.1,"A group of P-450 heme-thiolate proteins, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH---hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here.",384,1.0,-0.0854037,0.057990354,-0.010414096,-0.022516463,0.09280747,0.03874049,-0.056669153,0.101602696,0.011023656,-0.048271645,-0.006058168,-0.05713419,-0.05705773,-0.006809741,-0.028740734,0.010109293,-0.04539786,-0.01938895,-0.029171547,-0.06208799,-0.006833965,0.052492004,-0.014832738,0.05643652,0.0027441212,0.0151932705,0.07371039,-0.004190213,-0.09815136,-0.07879358,-0.033861753,-0.03803169,0.05706829,-0.026688142,-0.03656271,0.14627972,-0.054163165,-0.07997069,-0.044753022,-0.016104342,0.06566523,-0.05485325,-0.10339587,0.012750491,-0.013817909,-0.037389044,-0.014605761,0.07257806,-0.012832571,-0.0120043885,-0.031010468,0.0021694012,-0.04534493,0.038739514,0.09433779,-0.07757364,-0.03448438,0.028692864,-0.030588478,-0.056172334,0.028726406,-0.0114459265,-0.0016184681,-0.0006134493,-0.0021430687,-0.047433328,0.10086485,-0.06503176,-0.04451735,-0.06299829,-0.07317917,-0.019407677,-0.0059012584,0.00033817164,-0.050121717,0.10844785,-0.03600795,-0.056374867,0.031052448,-0.0061489264,0.046863288,0.03480051,0.002603792,0.06556845,0.054732524,-0.026318016,-0.040221293,0.008531123,-0.04487099,-0.0039199414,0.014268199,-0.013161842,0.058701783,0.03999317,-0.09385197,0.08321041,0.040511794,0.027538342,0.025960121,-0.0011001811,-0.0138324,0.09055417,-0.014398089,-0.06080886,-0.074858844,0.0253288,-0.018228978,0.1022005,0.0018762329,-0.011212844,-0.026762249,-0.08397752,0.012231746,-0.009892226,-0.0256561,0.10462856,0.020350236,-0.03328494,-0.07874921,-0.028474806,-0.01034713,-0.023074925,0.055635273,0.02667326,-0.052515283,0.002042206,-0.10743093,2.1548892e-33,0.105570555,0.03232044,0.0029739311,0.0037724634,0.046928924,-0.0072535393,-0.09091393,0.102039576,0.032163132,-0.024499126,0.0051774224,-0.03287545,0.07927092,-0.045973565,-0.05077654,-0.08696613,-0.03245708,0.027289657,0.003690963,0.016788388,-0.074853316,0.00436786,-0.042123757,0.016985886,-0.017018514,0.032732897,-0.05778172,-0.016010128,-0.019927973,-0.00015451561,-0.071498446,-0.07594159,-0.07904856,-0.028251609,-0.02150906,-0.018954394,-0.008920662,-0.021094782,-0.057376236,0.042718988,-0.03356684,0.03870693,-0.014087754,-0.116014116,0.0646867,-0.037195135,-0.108589545,0.07042325,0.0065930216,0.10029496,-0.0063803666,-0.042204827,0.12648688,-0.04953494,-0.010685547,-0.0126811005,-0.030341517,0.0166465,0.035070587,0.078496635,0.09126488,0.06924969,-0.032833736,0.022702798,-0.032572877,0.029700315,-0.10287943,-0.028834129,-0.021410676,0.07808734,0.0063618654,0.08567174,0.080749445,-0.019325864,0.019472096,-0.02131328,-0.028900612,0.06848036,0.0019529485,0.04015821,0.0027863944,0.018145436,-0.02454934,-0.04549437,-0.028201584,0.045180116,0.02602814,-0.010767228,0.02138724,0.038844004,0.042222966,-0.08092375,-0.014675708,-0.062026042,-0.00037339205,-2.0831332e-33,0.095939465,-0.052801896,0.015074331,-0.12563497,-0.00080658257,0.07930137,0.05786444,-0.013531719,-0.017907014,-0.049032155,0.114923954,0.0016628249,0.034097176,-0.014380724,0.01844738,-0.010868496,-0.005942219,0.022094982,-0.012249849,0.020019596,0.024027,0.05634946,-0.0151851345,0.074078314,0.04581539,0.014487876,-0.045070242,0.036076237,0.0923887,0.046278656,-0.050926138,0.0038124458,-0.0744589,0.018140605,-0.0063777925,0.06803997,-0.03909776,0.07003154,0.034492806,0.025759315,-0.0024813046,-0.016815448,-0.017407546,0.05626479,0.06783645,0.14110914,-0.09220278,-0.009399899,0.048924856,-0.08391908,0.032100458,0.0630711,-0.058841404,0.0654055,-0.017002614,0.03476464,0.0147255575,0.03410759,0.024843154,-0.06453129,-0.055436794,-0.03957827,0.020358019,0.021429932,0.017437944,0.013937515,-0.049343325,0.0072705364,0.050801087,-0.013705903,0.07582377,-0.036356382,0.046884436,0.0075626555,0.0024626283,-0.056382377,0.007906176,-0.015846504,0.0010406269,-0.012717563,0.042679586,0.0031629477,-0.015212559,-0.065667674,-0.035165373,-0.048870925,0.0036392016,0.066152506,-0.036191627,0.0192778,-0.058530733,0.052572753,-0.0818343,0.118462816,0.06254608,-4.715277e-08,0.039677765,-0.08844973,0.060870748,0.03147152,0.048837204,0.05273642,0.05814902,0.04917365,0.08003975,-0.0224904,0.01398265,0.103497475,0.04189225,0.025479438,0.04209606,-0.0012486294,-0.04020136,0.035548247,0.0077996003,-0.015652329,-0.044830203,0.0027399943,-0.045778826,-0.032969583,0.018525464,-0.092571706,-0.009024914,-0.05296235,0.032107953,-0.070809685,-0.01762395,0.044555508,0.036359947,-0.018220982,0.031278156,-0.0011652554,-0.047734894,0.02921898,-0.047191925,0.028982464,-0.050181173,-0.06881161,-0.07553886,0.018379621,0.08102482,0.027944155,0.051183484,0.036852855,-0.032982733,-0.029264748,0.025491692,0.033367794,0.044438496,-0.059355654,-0.110843465,0.036329284,0.029196896,-0.057808317,-0.013203774,-0.06990894,0.053610593,0.0012824081,0.16739117,0.004393595 +1.14.14.3,"The reaction sequence starts with the incorporation of a molecule of oxygen into reduced FMN bound to the enzyme, forming luciferase peroxyflavin. The peroxyflavin interacts with an aliphatic long-chain aldehyde, producing a highly fluorescent species believed to be luciferase hydroxyflavin. The enzyme is highly specific for reduced FMN and for long-chain aliphatic aldehydes with eight carbons or more. The highest efficiency is achieved with tetradecanal. cf. EC 1.13.12.18, dinoflagellate luciferase.",384,0.99999994,-0.046891958,-0.032729633,-0.10290873,0.01929592,0.09909127,0.010897107,-0.0540113,0.029800324,0.04856672,-0.017032217,-0.013001185,-0.044953186,-0.055779252,0.020909848,-0.10619012,0.04605277,-0.09403952,-0.0016571013,-0.02775708,-0.010210309,0.01259477,-0.028387798,0.026294155,0.004481793,-0.07824454,-0.005277411,-0.050341934,0.027939504,0.025521388,-0.08353026,0.10517729,0.026590807,0.0047899075,-0.05661052,-0.0029199189,0.025366817,0.011660163,-0.033660706,-0.017629858,0.02197357,-0.0088196425,-0.057257764,-0.014082724,-0.053430434,-0.032152284,-0.011459084,0.03985028,-0.0025155945,0.03450019,-0.02778209,-0.015061989,-0.060050707,-0.0754353,0.06046638,0.00841758,0.0065806992,-0.08781574,-0.08258637,-0.028826328,0.013815031,0.017497221,0.08248563,-0.035433426,0.04982899,0.035772312,0.0038958597,-0.0024877174,-0.094228685,-0.020166239,-0.03301045,-0.0632142,-0.029831812,-0.040379897,-0.011546428,-0.03700635,0.09060014,0.009224349,-0.045071613,0.027509602,0.0054883086,0.10065563,0.010002051,0.069834456,0.080106564,0.03848826,-0.028502269,-0.01052872,0.051031638,-0.019709345,0.144573,-0.022627795,0.050361935,-0.013024852,-0.033025384,-0.07784618,0.07744572,0.05903706,0.044852633,0.050400723,0.06666212,-0.0773102,-0.040517192,0.004924708,-0.03985814,-0.05088231,0.02340569,-0.0029069055,0.063068815,0.083008066,-0.02043082,0.0029437698,0.047386963,0.013218664,-0.033997968,-0.05090489,0.100361474,-0.026827835,-0.045038775,-0.030551264,0.049318187,0.004152985,0.029498538,0.025374599,0.11305121,0.011093436,0.03166707,-0.10708278,3.7505426e-33,0.04144115,0.061591104,0.004390863,0.0031298776,0.00046970855,-0.016023641,-0.057963498,0.011312505,-0.043166514,0.0040983204,-0.044155017,0.014822213,0.025400275,0.028297465,-0.03733765,-0.08338016,-0.02526891,-0.03470976,-0.040466834,-0.04092986,0.030028572,-0.011965933,-0.0067740576,0.002849877,0.004927174,0.066613644,-0.044635843,0.017868696,0.037933886,0.004359884,0.011475808,-0.0639065,-0.06693968,0.010710064,0.07164813,-0.026703872,-0.025300054,-0.08400634,-0.008722904,0.045398448,0.028381394,0.038332038,-0.028244346,-0.041131437,0.068066314,-0.037176155,-0.08789875,0.13159691,0.085899696,0.11166421,0.023014357,0.021100424,-0.025717763,-0.030079521,-0.05091791,0.04859205,0.0033828015,-0.019421414,0.033574905,0.010381222,-0.028078439,0.021807576,-0.052711878,-0.01588458,0.05101085,0.015339381,0.046864446,0.028401015,0.01768524,0.009737821,-0.030510796,0.025031334,0.056978453,-0.029395897,0.08243957,-0.017239025,-0.010967578,-0.018906713,0.030438239,0.003411037,-0.0014367623,-0.0040589496,0.0432309,-0.099035546,-0.038430892,-0.043582916,-0.05582387,0.0042705145,-0.0105630215,0.0053457846,0.016237902,-0.047686473,-0.0004966273,-0.027432546,0.0013995997,-3.4895924e-33,0.05332185,-0.06704758,-0.023145828,-0.038632106,0.006623211,0.034927726,-0.03667024,0.02926332,0.016519524,0.026100125,0.07463771,-0.0023540515,0.029245539,-0.06607201,-0.015721897,-0.02377983,0.014574066,0.03890897,0.011981353,-0.0173255,-0.031051233,0.082047865,-0.021237995,0.08115957,-0.026785534,-0.0029613613,0.060587946,0.0338492,0.029638141,0.09321583,-0.06934386,0.031354886,-0.0020174582,0.0018589783,0.014069496,0.024216421,-0.0015470182,0.03116539,-0.015644493,0.02557449,0.056916874,0.042991254,-0.006856649,-0.030841425,-0.043537013,0.1421008,-0.1395385,0.0015659514,0.06658355,-0.046669263,6.9806425e-05,0.02940939,-0.07685256,0.01354859,-0.04783761,0.036512874,0.075595744,0.0013286858,0.06256926,-0.023969674,0.022141723,-0.06228722,0.047062285,-0.02860319,0.023634635,0.112426914,0.002862073,0.078014605,0.046595335,0.0004518524,0.07170589,-0.0009141175,0.028553411,0.033936895,-0.0018560733,-0.027355436,0.056060363,-0.11844815,0.011744308,-0.010296347,0.041170448,0.04946456,0.017368412,-0.11141093,-0.02242494,-0.030768484,-0.0038207048,0.07808706,-0.037011705,-0.0016985055,0.062038038,0.09238031,0.018575704,-0.035423495,0.098077305,-3.8586567e-08,-0.028031342,-0.064628124,0.043372218,0.026347062,0.054733917,0.062245525,0.07856853,0.038933903,-0.026521321,-0.078662634,0.037081484,0.07734975,0.016413962,0.005594751,0.0615171,-0.012114803,-0.056443695,0.032315597,-0.05238571,-0.0049731876,-0.10073335,0.110479005,-0.00773256,-0.04677689,-0.056061026,-0.03958435,0.007248348,0.058553413,0.02927518,0.0043051047,-0.014445783,0.08074892,-0.07179133,-0.070431404,-0.17651838,0.016876863,-0.026834566,-0.05504861,-0.09467812,-0.023891307,0.003833652,-0.014639471,-0.03306345,-0.046549987,-0.010895669,-0.0030954625,-0.009064777,-0.012492444,0.0037392457,0.035224028,0.09298139,-0.02848953,-0.056112103,-0.043485366,-0.15148105,-0.046968546,-0.04183173,-0.042732768,-0.07898072,-0.09477544,-0.013591358,-0.03935108,0.21601951,-0.018254932 +1.14.14.5,"The enzyme from Escherichia coli catalyses the desulfonation of a wide range of aliphatic sulfonates (unsubstituted C1- to C14-sulfonates as well as substituted C2-sulfonates). Does not desulfonate taurine (2-aminoethanesulfonate) or aromatic sulfonates. Does not use FMN as a bound cofactor. Instead, it uses reduced FMN (i.e., FMNH2) as a substrate. FMNH2 is provided by SsuE, the associated FMN reductase (EC 1.5.1.38).",384,0.99999994,-0.0106133055,-0.040384974,-0.0931883,-0.017116055,0.0019792498,0.038825296,-0.025374638,0.0714707,0.032266848,-0.10359994,0.022852762,-0.008426127,-0.078705676,0.029838938,-0.07810039,0.0009374666,-0.030946096,0.012351467,-0.0029871124,-0.054174047,0.017114526,-0.0053284285,-0.05302499,-0.031301536,-0.047688916,0.052203268,0.012500603,0.0014854922,-0.06500724,-0.07983882,0.06925643,-0.041829847,0.02897409,-0.027298093,0.0055227913,0.024087444,0.01820504,-0.05737,0.040516347,-0.05602015,0.00080456934,0.04603121,-0.023441171,-0.025785115,0.012228385,-0.03212792,-0.023436459,0.07145707,0.010561391,-0.063567035,-0.0625537,0.04238484,-0.07095737,0.11231831,0.0889506,0.07472477,-0.05033231,-0.112753086,-0.041631613,0.022544958,-0.033379927,0.03426763,-0.008359826,-0.08496622,0.012355482,-0.036190894,0.02969523,-0.075853705,0.044172477,0.018862292,-0.09746365,-0.017021189,-0.009890515,0.007545285,-0.002759017,0.08041384,-0.045839366,-0.037919413,0.0557097,-0.05440547,0.03190612,0.02018292,0.025407622,0.057975568,0.06868769,-0.06689192,0.0047553782,-0.061321486,0.11231348,0.11021602,0.0185409,0.023841476,0.015664348,-0.042910162,-0.089953095,0.04162187,0.0049552773,0.16437593,-0.0033480492,0.022923317,0.0066982335,0.055752587,-0.07730737,-0.105057195,-0.08610708,-0.021577425,0.05067022,0.11430941,0.030379811,-0.024108589,-0.042088084,0.035267424,-0.02519348,-0.02569822,-0.020574236,0.10946123,0.047738932,-0.09735369,-0.064312175,-0.04412031,-0.019741418,-0.02158767,-0.020142673,0.045271408,-0.0037651283,0.027084129,-0.17426535,4.6876496e-33,0.080230735,0.1037807,0.0858422,-0.017924946,-0.05555704,-0.02301487,-0.09529995,0.047145534,0.006397548,-0.019532291,-0.07447239,0.0039628195,-0.013604552,-0.06598383,-0.0036437316,-0.08160404,-0.009158596,0.0051697427,0.054485936,-0.037455916,0.044422187,0.04645258,-0.004084004,-0.06975778,0.019651761,0.01689933,-0.02070953,-0.0029606656,-0.005091796,0.042970173,0.038251426,-0.06101194,-0.07660111,0.04285278,0.09355153,-0.0187476,-0.1043821,0.009607138,-0.01375129,0.0729234,0.0059208903,0.0379959,0.02087509,-0.017590487,0.017676057,-0.04554,-0.05420962,0.08856042,0.07343611,0.11764793,-0.020093516,-0.031767365,0.07125098,-0.032928072,0.029889109,0.021098807,0.038903162,-0.004910405,0.03796394,0.048590943,-0.028968701,0.064367205,-0.100311674,-0.012190055,0.051859684,0.038231958,-0.010735377,-0.014322338,0.02721631,0.04954633,-0.025389059,-0.034390885,0.04559609,0.057705462,-0.009990043,-0.02704266,-0.01186767,0.007851227,0.055381007,0.018731581,-0.006133696,0.005292576,-0.07964787,-0.034475602,-0.06301681,-0.0034527665,-0.060301468,-0.024938164,-0.029857485,0.025334774,0.02275259,-0.079585806,-0.043682512,-0.016334046,0.0046693454,-5.7212853e-33,0.05536219,-0.079084955,-0.045400724,-0.092008434,-0.07658013,0.035499625,0.010731671,0.0031864196,0.015347457,0.012627337,0.035711195,-0.0051484453,0.036592558,-0.025554366,-0.023974108,0.012674341,0.06775594,-0.018715495,-0.0020176996,-0.010325526,-0.00074154034,0.10193972,-0.04006302,0.090953544,0.013043218,0.03306271,0.10999495,0.07105147,0.11152601,-0.018450173,-0.023798663,-0.04632157,0.021905163,-0.08491106,-0.029938,-0.002474078,0.0009570289,0.02520163,-0.027815277,-0.039192967,0.02003429,0.021457274,0.03779926,0.10113052,0.025094902,0.07025905,-0.090942584,0.029441688,0.07088047,-0.0029066505,0.059306625,-0.05989003,-0.052875265,-0.0048005693,-0.017222729,-0.023958419,0.028222572,-0.003255865,-0.029937778,0.0011751378,0.0042259474,-0.015294945,-0.0017282433,-0.095282674,-0.02011862,-0.009913397,-0.015619516,0.0026951388,-0.0018866964,-0.020445906,0.028147994,-0.025853885,0.019152425,-0.037028786,-0.08603023,-0.03691827,-0.04297469,0.04264833,-0.00054976123,0.012313154,0.05542112,0.0023485378,0.000420842,-0.09413718,0.03205499,-0.077179916,0.027928086,0.090927504,-0.007496713,0.04951077,0.022235,0.0054731686,-0.020593721,0.051646747,-0.033167295,-4.4461018e-08,0.008233487,-0.06879547,0.052886523,0.0109151965,-0.015750919,0.062874675,0.052255504,-0.024916006,-0.0037228828,-0.017599994,0.004423088,0.13275252,0.026656467,-0.019912606,0.0038253823,0.017727569,-0.019958945,-0.01773336,-0.018889287,-0.011331079,-0.03800883,-0.008045986,-0.11975924,-0.005630152,0.069849916,-0.054033596,0.058780238,-0.048487473,-0.012596018,-0.022263253,0.017589485,0.03705012,0.027427185,-0.012635684,-0.05908946,-0.027407497,-0.018839262,-0.07951126,-0.040035546,0.0042936886,0.028611751,0.09119583,-0.07081042,0.04908181,0.0062860213,0.042435054,-0.0039985264,0.05628133,-0.03187666,0.035027746,0.03547447,-0.019335361,-0.02047699,-0.060729172,-0.1297879,0.041292176,0.055687763,-0.07565508,-0.027487148,0.006828521,0.09081948,-0.012073315,0.14144476,0.07313976 +1.14.15.1,"A heme-thiolate protein (P-450). Also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide.",384,0.99999994,-0.022725858,-0.046228766,-0.021256987,-0.0016628513,0.108038805,0.036093306,0.064744994,0.105146386,0.033315822,0.00066522334,0.006206595,-0.010823229,-0.11665105,0.04936867,-0.0010253409,0.0038084784,-0.04543019,-0.001741275,0.0051475316,-0.084988,-0.007387993,0.039107196,0.022819594,0.026302692,-0.05136141,0.017945807,0.08051504,0.045445047,-0.024703458,-0.06994285,-0.040874746,-0.024262242,-0.020001873,0.0012456225,0.0060540684,0.08332288,-0.0690908,-0.04558138,-0.04084795,-0.037134323,0.15370354,-0.108025156,-0.044051938,-0.022223907,-0.017131522,0.0058172825,-0.04475418,0.12760337,0.0074778837,0.01951269,-0.02261295,-0.06585415,-0.0874859,0.05689342,-0.051883377,-0.014262931,-0.02083132,0.047515754,0.003629501,-0.0451809,-0.042071383,0.06498109,-0.011264844,-0.011067733,0.0060163448,-0.073374696,0.028491307,-0.009873166,-0.04094195,0.022899885,-0.00017348731,-0.07043021,0.0052463193,0.0132393595,-0.044214204,0.04485388,-0.06587336,-0.01120692,0.048567925,0.0012831962,0.02646739,0.100439966,0.04563396,0.076441586,0.026127499,0.021394297,-0.014941455,0.034340218,-0.023437398,-0.047497857,0.0058660423,-0.023150215,-0.07064904,0.022280555,-0.09737716,0.06304999,0.033457525,0.0013613972,0.00412924,-0.0013408938,-0.009778301,0.035158366,-0.012950176,-0.10490509,-0.1198683,-0.01961361,0.018353974,0.04769253,0.07767405,-0.06559505,-0.058767933,-0.04739356,0.06567123,-0.025396708,-0.03543112,0.083588354,-0.032972105,0.0039162016,-0.016738568,-0.031798344,-0.024402568,-0.0009541625,0.047790002,0.056991246,-0.1181061,-0.01539091,-0.052763578,-1.8706725e-33,0.06306748,-0.061071713,0.05676104,0.098066874,0.042912796,-0.0118289795,-0.10857363,-0.01113716,-0.026526812,0.036546748,-0.063077234,-0.12484074,0.032070298,-0.007320864,0.00012917361,-0.07864113,-0.07384541,0.04860329,0.05588924,-0.0098424,-0.07158393,0.08431351,0.0049035368,0.01311336,0.026145443,0.08527521,-0.0031648655,-0.04117045,0.05197014,0.012015088,-0.0034467399,-0.023038812,-0.0572048,-0.035098985,-0.0035057827,0.008225494,-0.011357254,-0.009588332,-0.063570395,-0.013147689,0.014260766,0.0017558318,0.0018748468,-0.048061714,0.019326242,-0.11315947,-0.04923344,0.03704211,0.017754683,0.020906426,0.072866455,-0.025439147,0.11189719,0.037216622,-0.103549615,0.0036119034,-0.0345518,0.070514955,0.013561258,0.04376686,0.110098176,0.07423915,-0.027910743,-0.018694105,-0.029585814,0.058711074,-0.074038476,-0.020440212,0.037096266,0.062722184,-0.014287552,0.032236684,0.09203305,0.0023814715,0.039453425,-0.013660775,0.04020442,0.07569738,0.012761159,0.041215017,-0.031704806,-0.05866822,-0.018811937,0.06659341,-0.092272,-0.009069368,0.07190477,-0.018206753,-0.00079856307,0.010624517,0.07118964,-0.07186723,-0.04147451,-0.0015488099,0.02760391,8.688649e-34,0.052255843,-0.086426534,0.036503553,-0.070178226,-0.015822489,0.028934369,0.014675337,-0.09637497,-0.038473222,0.008303738,0.10324448,-0.0064312946,-0.01956549,-0.04434827,0.030277183,0.043644764,-0.049392693,0.00065597234,0.0026410143,0.030724984,-0.0019735002,0.021312872,0.018527929,0.061426252,0.05051136,0.07699709,0.02532046,0.010228258,0.07876707,0.0064064986,-0.0024536827,0.0036807593,-0.041331988,-0.026838735,-0.062153373,0.010463569,0.04290601,0.0076725157,-0.019054465,-0.018196408,0.01565222,0.047606904,0.061944585,0.06391074,0.05890816,0.10644297,-0.03470621,-0.046855602,-0.035121825,-0.04758742,0.022526223,0.004615314,-0.05994607,0.011354538,0.012646608,-0.032374978,-0.040040188,0.031558752,-0.05152718,-0.03761759,-0.026988769,0.030449688,0.0007261519,0.07312491,0.029450051,0.006010471,-0.06952393,0.007397281,0.036249314,9.5102514e-05,0.045523968,0.03125833,0.044502884,0.06898222,0.013797342,-0.055465095,0.033210766,-0.028665198,0.04198371,-0.037209146,-0.048773628,-0.023436977,-0.09503764,-0.07160279,0.01869574,-0.038287178,0.012363119,0.13715866,0.048478168,0.028142704,-0.014415478,0.04791677,-0.060769092,0.0925967,0.052609254,-3.656034e-08,-0.012722996,-0.14396954,-0.0017754905,-0.053311087,-0.051829755,0.0011719443,0.04935415,0.016393257,0.050960913,-0.047901787,0.015929164,0.02745991,0.030108377,-0.0318423,0.04177025,0.028352072,-0.033430573,0.053881396,0.0089104865,-0.036723938,-0.091994956,0.0073184147,-0.013242691,0.009978394,0.0098096365,-0.0918654,-0.0306941,-0.009411007,0.022540528,-0.03616958,0.046870243,0.094520256,-0.041725323,-0.021768762,0.042020965,0.10339867,-0.061195873,0.008199358,-0.06375323,0.051616833,-0.017295718,-0.039522376,-0.042993374,-0.06702109,0.034917198,0.0316342,0.018207395,0.051850475,-0.036403503,-0.02618231,-0.008616667,0.029395146,-0.017900255,-0.05135939,-0.143659,-0.0073318663,0.039747886,-0.03840349,0.04630534,-0.12852542,-0.008713064,0.019693514,0.16448969,0.026288418 +1.14.15.2,"A flavoprotein which requires Fe2+. Isolated from Pseudomonas putida. The product is spontaneously converted to [(1R)-5-oxo-2,2,3-trimethylcyclopent-3-enyl]acetate. The enzyme slowly oxidized (-)-camphor.",384,0.99999994,-0.04249757,-0.0230905,-0.1373122,0.09846778,0.11117709,0.05482821,-0.018355483,0.044880223,-8.5885964e-05,-0.093591586,0.033252373,-0.0154271815,-0.080914885,0.037033007,-0.081548825,0.04258016,-0.028819758,0.036567703,-0.02331902,0.041527286,-0.008845715,0.045064416,-0.008180854,-0.009324042,-0.024620276,0.023726813,0.050455894,-0.039581895,-0.031031398,-0.030145643,-0.021945339,-0.002612974,0.07107867,-0.05529975,0.0003517696,0.040944267,0.0068809213,-0.022415567,0.03610704,-0.018742066,-0.0023264217,-0.06406155,-0.016327996,-0.06188447,0.0287374,-0.07629407,0.05327945,0.053782824,0.044400223,0.015585332,-0.10701182,-0.00906388,-0.06772725,0.060532972,0.0342237,0.000523569,0.028213266,-0.064083844,-0.06352017,0.0053885877,0.036090247,-0.033745173,0.0066105304,0.021508044,-0.019517941,-0.058887944,0.025768066,0.01025753,0.048287496,-0.011964833,0.015091965,-0.011133775,-0.025246328,0.032306183,-0.007980292,0.03521079,0.019597968,-0.02616632,0.13031876,-0.00032475335,0.06083818,-0.04549937,0.01353723,0.08537743,0.039793447,0.003421843,-0.056065064,0.038086846,0.009959259,0.062324088,-0.059654128,0.038304187,-0.03482408,-0.019302726,-0.053717814,0.028794523,0.050519545,0.0032065257,-0.045506705,0.05337011,-0.05969793,0.01215803,0.03827697,-0.07880692,-0.06332389,-0.025768591,0.0025099565,0.026531331,0.007427596,0.007941812,0.041481964,-0.041460145,0.018536324,-0.07101136,0.010904983,0.07021662,0.030519096,-0.07917535,-0.03306519,0.037182905,0.042640097,0.077617615,0.017856369,0.07751881,-0.04143515,0.0040434464,-0.09348832,1.3533514e-33,0.060968548,0.052404717,0.025507532,0.041461807,0.027470758,0.006874312,-0.06895372,-0.05863258,0.0030259397,0.013971691,-0.06987061,-0.07080002,0.017568633,-0.013007465,0.07399097,-0.07765829,-0.042172056,-0.018532777,0.12128484,-0.06938635,0.015578584,0.08501445,-0.040411938,-0.013638017,0.050559774,0.005994562,0.011106264,-0.081677996,0.033941824,0.043201063,0.050165057,-0.04206552,-0.09829746,-0.055397365,0.032454077,-0.033201993,-0.075008154,-0.06758999,-0.08274466,0.04458553,0.034919057,0.06580776,-0.03758224,-0.02811098,0.074775636,-0.09033819,-0.06943082,0.18588114,0.015404029,0.12922165,-0.022284541,-0.044436898,0.063776664,0.078706205,-0.13587265,-0.019050933,-0.027616847,0.027509257,0.03826254,0.037104186,-0.002058516,0.07787473,-0.0029764273,0.02148337,-0.038641583,-0.06490294,-0.082481004,0.004324841,0.016152875,0.04953005,0.0008695108,0.05476011,0.029922811,0.021112017,-0.019335823,-0.099418946,-0.065967456,-0.00067926844,0.024489803,0.013020368,-0.015300779,-0.06375708,0.01591558,0.011244522,-0.10347299,0.063061796,-0.03844065,0.008147555,-0.048928946,0.0043200175,0.050857544,-0.0151042435,-0.012011242,0.007367125,0.019764844,-1.5747527e-33,0.010863333,-0.13088223,0.01749031,0.013955288,0.0013406271,-0.0026797578,-0.0496826,-0.023385182,0.010922861,0.00092935195,0.012846335,-0.04698807,0.098508395,-0.08313678,0.06563423,0.04090584,-0.043831695,0.0772262,0.049940664,0.010307,0.018863974,-0.016516842,-0.02493039,0.08718607,0.06959694,0.025375122,0.0008616445,0.01160524,0.01992168,0.09578427,-0.0108080385,0.026074784,-0.06734878,-0.07489992,0.0037792656,0.04036941,-0.015651902,-0.0067080758,0.045441523,0.06803158,0.0010869076,0.051911283,-0.0119655905,0.08585638,0.029474925,0.06302157,-0.032736033,0.033999268,0.07607126,-0.04977778,-0.0044084536,-0.013600653,-0.09139426,0.036805175,0.051900215,-0.021875966,0.04727224,0.050244182,-0.0721178,0.008368125,-0.024363369,-0.09677298,-0.0017280099,-0.019902138,0.08464598,0.055228114,0.024796108,0.09987682,-0.018052047,-0.011666361,0.068934724,0.0015650225,0.008735117,0.040000074,-0.00012724375,-0.03894152,-0.0035961457,0.038769983,-0.017878372,0.016924884,0.039502636,-0.07347814,0.022165004,-0.033606302,0.022741873,-0.12785104,0.030033914,0.06345961,-0.041107245,0.009898502,-0.038900197,0.04487251,-0.057660833,-0.01926196,0.0004344588,-3.7414424e-08,0.027304675,-0.11216483,0.03324362,0.01488684,0.02015937,0.004428361,-0.010706163,-0.055882093,-0.009485785,-0.06928019,-0.017028445,0.10553309,0.020083927,0.02169893,0.052059453,-0.035778258,-0.008678144,0.08605229,-0.035828482,-0.041917562,-0.0934222,-0.004592951,-0.07030518,-0.03178997,-0.054616895,-0.040061075,-0.016764723,-0.024877183,0.13753675,-0.041698713,0.014099373,0.04610866,-0.03264851,-0.029331326,-0.16440967,0.042017132,-0.022418013,-0.014574557,-0.07664198,0.04427762,-0.04062695,-0.011554777,-0.029316783,-0.029278666,0.0038656874,-0.037150916,0.036575776,0.020729685,-0.02923814,-0.08392417,0.037224744,0.024528084,0.046880797,-0.0014146778,-0.018123854,0.04957682,0.01804718,-0.0072900867,0.041655015,-0.055946093,-0.013827402,0.043324478,0.10084869,0.05943245 +1.14.15.3,Some enzymes in this group are heme-thiolate proteins (P-450). Also hydroxylates fatty acids in the omega-position.,384,1.0,-0.055503756,-0.03082126,-0.035814032,-0.007962786,0.042616133,0.057087403,-0.079635054,0.0655316,0.00012597773,-0.071627975,-0.0024266052,-0.018857941,-0.09973666,-0.008540227,0.04380018,-0.013321981,-0.055428226,0.00940746,-0.0509219,-0.12421989,0.02339893,0.050978668,-0.021987585,0.029248796,-0.049792096,0.0038703876,0.05694424,0.017046386,0.014277586,-0.038171407,-0.045862805,-0.07415985,0.046223458,0.011552296,-0.02909147,0.123960346,-0.05606489,-0.07697213,-0.03949125,-0.04016813,0.15682067,-0.07392772,-0.06310299,-0.0025664626,-0.0051461123,-0.024156826,-0.019862315,0.049100745,-0.014763989,0.032573286,-0.06284044,-0.08079997,-0.048620254,0.049211863,-0.04910662,0.0010173504,0.0064417874,-0.018034006,0.0046759644,-0.010385151,0.011004017,0.020760955,0.0002919237,0.030909194,-0.0062350044,-0.041782875,0.0116352625,0.008621504,-0.05096708,-0.062397987,-0.010386637,-0.086823724,-0.02783287,0.058348216,-0.040263172,0.050828416,-0.079475895,-0.05593969,0.02780941,-0.026005955,0.018390743,0.03692988,-0.032055683,0.14305371,0.059923265,-0.011360778,-0.048406526,0.04568416,-0.10179818,-0.04054678,0.00885227,-0.019368185,-0.028589686,0.020798044,-0.05626359,0.054600544,0.000110854926,-0.011801094,0.014033915,-0.05397379,0.013989277,0.043161295,0.012385109,-0.0653823,-0.09782385,-0.0017625883,-0.055544153,0.060968425,0.072019204,-0.010442757,-0.040158864,-0.012802673,0.041516367,-0.013687305,0.008030432,0.06090388,-0.016505778,-0.030518895,-0.02240682,-0.049938213,-0.049497813,-0.044608563,0.09377076,-0.010708778,-0.031436846,-0.015394325,-0.0706169,-9.465366e-34,0.08481908,-0.059560478,0.005920987,-0.035220552,0.03243097,-0.05673258,-0.05685429,0.053979665,-0.002588984,0.035681773,-0.007819322,-0.04633641,0.009268772,0.0012865183,-0.00829276,-0.08697308,-0.004148171,0.07741176,0.0142796775,0.03107456,-0.026590703,0.060817253,-0.013438877,-0.013879192,0.004168031,0.06555978,-0.03570805,-0.027117185,0.030239074,0.02086203,-0.054552924,-0.09223894,-0.07577963,-0.038131036,0.04554432,0.021801025,-0.00918102,0.007737936,-0.05757542,0.03520481,0.040104665,-0.06264664,0.0064895484,-0.09197991,0.045519397,-0.0228468,-0.063995495,0.043407734,-0.00068904075,0.043168545,0.07438596,-0.05057529,0.08614723,0.011786643,-0.03564512,0.0077834395,-0.012568442,0.09608383,-0.034423918,0.03540892,0.095475696,0.094243966,-0.055291407,0.0483197,-0.015805148,0.014379507,-0.07612551,-0.05198888,0.013869126,0.14176674,0.01897929,0.020967832,0.101589106,0.012417033,0.046729963,-0.037463427,-0.02424349,0.0879445,-0.0064348504,0.016512519,0.04308395,-0.0044248225,0.0075319177,0.026136955,-0.07423677,-0.007503576,0.034004662,0.013310436,0.013673586,-0.02403048,0.011854182,-0.053193495,-0.0057326253,0.046496984,-0.04372852,-6.895196e-34,0.08086003,-0.098264955,0.057770606,-0.093809575,-0.015111283,0.044214267,0.04778328,-0.0028225458,0.02474901,-0.016693106,0.12436083,-0.032438535,-0.029936181,-0.033429585,-0.01333187,0.058554724,-0.05627284,0.022849219,-0.010719427,-0.0029941646,-0.00061555224,-0.0009884466,0.029001456,0.1293549,0.056289088,0.06679858,0.035618015,0.041802704,0.06161995,0.037178747,-0.033674378,0.05643117,-0.0451741,-0.06410475,-0.080897674,0.020420806,-0.042166386,0.041128,-0.018900968,-0.01046546,0.025740191,0.04238691,0.08603149,0.06610904,0.023227485,0.089101054,-0.027848156,-0.046937324,-0.057924904,-0.030910084,0.035650454,0.027598578,0.011230194,0.065188214,-0.0052293832,0.051283013,-0.03815905,0.026082324,-0.036841672,-0.12067041,-0.07106312,-0.037872385,0.02349469,0.04925602,-0.0092859315,0.056493755,-0.053062256,-0.039946705,-0.020734234,0.036419634,0.029260112,0.025577797,0.02981132,0.08319897,0.005061335,-0.03579985,-0.022506794,-0.03079277,0.007517915,0.0045538945,-0.009234767,0.018042717,-0.090793006,-0.08702627,-0.020866804,-0.04493967,-0.040028296,0.07246784,0.050288722,0.026270246,-0.04483571,0.048163537,-0.09952343,0.03214578,0.03986252,-2.7181052e-08,0.028470637,-0.112292744,0.029585132,0.018619891,-0.054322574,0.011771229,0.015159483,0.042105295,0.07544285,-0.024741074,-0.027419982,0.061613515,-0.009085784,-0.030626561,0.011515741,0.00949978,-0.006577325,0.03911044,0.026663017,-0.047395557,-0.01860099,0.0066603613,0.029003752,0.029967519,0.039855607,-0.04258596,-0.031809248,0.014139497,0.05676819,0.0096415365,0.016416112,0.048990767,0.012212383,-0.020780448,0.07141565,0.087689005,-0.022826318,-0.01924018,-0.070924014,0.062372282,-0.01842588,-0.04118637,-0.08975571,-0.028829126,0.029579302,0.0075835935,0.00018157724,0.1075246,0.029267887,-0.06795569,-0.01881833,-0.003883523,-0.037401598,-0.082726724,-0.1305761,0.04483458,0.044460624,-0.09045383,-0.06459528,-0.058051705,0.02969244,0.009252148,0.24460627,0.020682542 +1.14.15.4,"A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.",384,1.0,-0.042461134,0.03159891,-0.023941973,-0.043026958,-0.063896954,0.01775842,-0.041008208,0.06682558,-0.006569211,-0.027082676,0.0015206548,0.028861698,-0.07354138,-0.0057682698,0.003822172,0.029207906,-0.0030044985,0.061946616,0.021804322,-0.09429395,0.02973089,0.027889805,0.022006735,0.039107997,-0.0088309385,0.024391118,0.0435264,0.07528974,-0.03216771,-0.010935156,-0.026899379,-0.04240796,-0.003092232,-0.02120802,-0.014171956,0.13910569,-0.08007779,-0.049477354,0.029783385,0.017794253,0.12502329,-0.13901074,-0.038930286,0.026854638,-0.004376727,-0.0006015617,-0.049459074,0.09021119,0.011838197,0.021722592,-0.0019343426,-0.08291698,-0.0408653,0.056312528,-0.044978883,0.021719338,-0.018521367,0.033247232,0.010788225,-0.026112674,-0.016173353,0.054905307,-0.07458402,0.029857036,0.03837101,-0.024720134,0.019420208,-0.009641637,-0.022108499,-0.04675211,0.041599758,-0.041104987,-0.06345918,0.034566868,-0.073648006,0.020481426,-0.056295298,-0.055183407,0.03727079,0.010006396,0.07643878,0.0816306,-0.013611048,0.10207716,0.06458306,-0.022604352,-0.03605371,0.047089532,-0.076641664,-0.017756648,-0.038238496,-0.016833328,-0.026606778,0.038030576,-0.081440456,0.015579702,-0.044644956,-0.0063967337,-0.0046504377,-0.00010899756,0.05002048,0.072122365,0.006576467,-0.041198574,-0.082984805,0.01762165,-0.028767487,0.07192218,0.03888136,-0.013480598,-0.058464892,0.012313972,0.01067437,-0.043064944,0.045823578,0.12935753,-0.038105514,0.047885265,-0.019049149,-0.07801142,-0.03976474,-0.004375697,0.004277923,0.03673938,-0.066344835,0.018560145,-0.05609247,1.1041318e-33,0.12275351,-0.010680813,0.038270153,0.060831647,-0.04532104,0.037413515,-0.048092227,0.019420663,-0.03040364,-0.033989616,-0.032972235,-0.060332384,0.04970816,0.05400042,0.019959297,-0.11622113,-0.010300254,0.10447832,0.10087606,-0.026726482,-0.06393803,0.101363204,-0.034950554,0.027525008,0.015390819,0.04262062,0.0028214233,0.016412444,-0.018933104,-0.005087027,-0.07930673,-0.01383693,-0.018513845,-0.100057416,-0.05059056,-0.026368795,-0.014021546,-0.027980642,-0.04013112,0.06755484,0.043475352,-0.010757657,-0.008659404,-0.061652135,0.076601885,-0.03281641,-0.055557005,0.004995245,0.00022106296,0.0477515,0.057856947,-0.046686377,0.076008126,0.029420132,-0.09537328,-0.015516211,-0.0051510087,0.04450824,-0.009675041,0.02495485,0.15000997,0.09192784,0.024639772,0.03678196,-0.06895122,0.021386009,-0.028975124,-0.07321824,-0.025887148,0.12133384,-0.07134752,0.014456808,0.027038863,-0.023229755,0.038793776,-0.03367104,-0.035888705,0.044826895,0.010432693,-0.023825841,0.013822924,0.007906267,-0.006123515,0.04591241,0.021391777,-0.0028257123,0.051673125,-0.009198117,0.05102183,-0.0013298348,0.03501499,-0.08609121,-0.025490025,0.0015732921,0.014619847,-1.3257981e-33,0.082704306,-0.09808883,0.056492038,-0.043274846,-0.029738825,0.034457337,0.06870668,-0.053598724,-0.022762828,0.02161008,0.10595762,-0.049882397,-0.040213928,-0.08611495,0.048713606,-0.04356777,-0.11145305,-0.04691299,-0.05329228,0.052935623,0.02764473,0.046449073,0.030652773,0.047299605,0.03457065,0.0122623285,0.014712791,0.005666963,0.13539347,0.03393112,-0.07654607,0.0007294752,-0.04470466,0.001945385,-0.05123241,0.11255508,-0.016226213,0.06198993,-0.010086645,-0.0083498685,-0.044546057,0.047749385,0.04764017,0.073013216,0.019046284,0.06304472,-0.021356538,-0.06279865,-0.04342447,-0.009654598,0.01629728,0.029864483,-0.04834056,0.0690079,-0.043163635,-0.055083137,-0.07362763,0.0059339623,-0.027844317,-0.111669935,-0.030860228,-0.010378832,0.017467592,0.0004026616,0.010665018,0.06275049,-0.021165982,-0.012501492,-0.029381903,0.05234038,0.07229059,0.013508055,0.093524985,0.08323671,0.049466446,-0.038377464,0.0056953304,0.0041107275,-0.020531304,0.008204978,-0.04573699,-0.009482467,-0.045780327,-0.03369234,-0.01472791,-0.02486225,0.02924299,0.05109244,0.0072304993,0.06014708,-0.00020018792,0.035265565,-0.077541485,0.015275007,0.035070408,-3.0159672e-08,-0.009482211,-0.07809594,0.0018417187,0.019247537,-0.028303428,0.0021256974,0.058948554,0.008053619,0.07245027,-0.05246971,-0.008469488,0.04276748,0.04634482,-0.03301612,0.0003727726,-0.03391621,-0.01339509,0.08033036,0.00792606,-0.02408779,-0.07650924,0.0060953703,0.0055178762,-0.006781435,0.032566153,-0.04908862,-0.042814314,0.013521349,0.04750279,-0.015742285,0.08395257,0.01585804,-0.027489305,-0.027522368,0.08883668,0.12344344,-0.050596856,0.017728973,-0.028416384,-0.020849872,-0.060198512,-0.13896537,-0.041438024,0.033005815,0.06380754,-0.022837773,0.009411884,0.056145065,-0.0056322957,-0.016137216,0.008454868,0.0067853904,-0.012605422,-0.13386302,-0.09636664,0.0441879,0.013600765,-0.09230056,-0.05419741,-0.089353606,0.029070195,-0.035220638,0.16754273,-0.009602499 +1.14.15.6,"A heme-thiolate protein (cytochrome P-450). The reaction proceeds in three stages, with two hydroxylations at C-22 and C-20 preceding scission of the side-chain between carbons 20 and 22. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase.",384,0.99999994,-0.10042322,0.058300305,-0.04696444,0.010174141,0.0458839,0.05743663,-0.026332483,0.080528766,0.008152951,0.008595283,0.018999517,-0.028528335,-0.04547865,0.019660866,-0.02987782,0.022572596,-0.07606556,-0.0018711766,0.025747215,-0.04445257,0.0034251474,0.019434046,0.017590849,-0.0060370145,0.04031661,0.026913023,0.017167378,0.030682981,-0.045891084,-0.02589702,-0.010460788,-0.015933083,-0.025636222,0.016346341,-0.027350303,0.117227644,-0.07850266,-0.052438285,-0.022932561,-0.012765739,0.07418223,-0.033845093,-0.100086816,0.01352185,-0.001044496,-0.05589488,-0.018561577,0.0803002,0.028640142,-0.03659469,0.01674549,-0.027754406,-0.018223232,0.052220516,-0.037609655,0.01668873,0.008855739,-0.01849777,0.019023798,-0.05451744,-0.053188954,0.02982394,-0.09605355,0.024849487,0.074395575,-0.075252354,0.018907074,-0.03877127,-0.027512062,-0.06861707,-0.03345537,-0.059548937,-0.04106697,-0.046033308,-0.08202582,0.041971296,-0.045905612,-0.04117693,0.025403535,-0.011491586,0.051855806,0.0012499272,-0.023901837,0.120492496,0.067818336,0.010356463,-0.027256079,0.016910957,-0.078018785,-0.020883683,-0.06052756,0.012096561,-0.059028648,0.048623405,-0.13040659,0.034471143,0.05972114,0.04500247,0.061112843,0.0070677684,0.0414595,0.13225758,-0.0072814305,-0.108587,-0.03486113,-0.020722112,-0.011389399,0.12315152,0.062320143,-0.01227529,-0.021057025,-0.058421426,0.045733932,-0.033359274,0.016583914,0.15861103,-0.07349541,-0.0046479995,-0.021344682,-0.05280865,-0.010910963,-0.0064692977,-0.037017774,-0.0049600764,-0.052143626,-0.017893266,-0.06831294,2.352738e-33,0.14627792,0.0037755587,-0.0053729205,0.0696404,0.010852286,0.055547006,-0.104930125,0.021942507,0.0005617923,0.0038009675,-0.054395385,-0.08030555,0.034077358,-0.0037863785,-0.0614267,-0.09048306,-0.047345467,0.019678645,0.07633939,0.0081632845,-0.025756678,0.04484112,-0.03770702,-0.0023767804,0.008200811,0.05961952,-0.09673264,0.04967723,-0.024638083,0.014252166,-0.004746239,-0.027977137,-0.11023764,-0.026912471,-0.0048697493,-0.054551203,-0.029780533,-0.020944353,-0.022693979,0.036044326,-0.030174058,-0.005186349,0.021524321,-0.08132767,0.06538217,-0.045727465,-0.10209324,0.025830833,0.04108244,0.1056619,0.058966044,-0.0602045,0.11131652,0.011748858,-0.06376638,0.027912611,-0.031316333,-0.026716508,-0.0032489395,0.10815915,0.14528944,0.11279989,-0.04625515,0.068391606,0.004723027,0.10994229,-0.032756485,-0.069412835,-0.03710222,0.10200894,-0.059937585,0.06718572,0.0997773,-0.060930215,0.0538296,0.01575683,-0.035206895,0.05180908,0.037870258,-0.008360763,0.008344031,-0.026517497,-0.02820262,0.013793752,0.014837758,0.013488089,0.0300272,-0.045327526,-0.02191685,0.04030371,0.038729228,-0.12703824,0.019349925,-0.0462463,0.019559648,-3.49931e-33,0.10151278,-0.055353984,0.02813903,-0.13718916,-0.024126315,0.051086936,0.030527698,0.008450942,-0.011460474,0.016867809,0.098431386,-0.002126552,0.003923304,0.001297597,0.005623767,-0.02835682,-0.020633055,-0.008532367,0.022058692,0.04913435,0.028633349,0.012591884,0.014267435,0.028550051,0.08282157,-0.032453053,0.011600731,-0.036998875,0.11511054,0.014638058,-0.05317497,0.026540691,-0.040189654,-0.0042649508,-0.034401562,0.106748745,-0.0075364076,0.01087102,0.027653083,0.0023599865,-0.029359385,-0.001019565,-0.009883818,0.058147248,0.08204337,0.07631592,-0.0991346,-0.021238014,-0.027304387,-0.036813308,0.030839192,0.05445194,-0.018139051,0.00589723,-0.019531941,0.013927447,-0.015623334,0.028355058,0.011675469,-0.07268185,-0.045548577,-0.03803348,-0.015785705,0.018744254,0.010118211,0.034006245,-0.06863228,0.024801716,0.042565953,0.0041738735,0.06831762,0.037689846,0.0559854,0.03708648,-0.011050815,-0.090388045,0.017714618,-0.02997442,0.050382864,-0.024872364,0.00062832003,0.031010954,-0.021867849,-0.051551044,-0.008492116,-0.052348524,-0.03539617,0.046635017,-0.016409213,-0.03198098,-0.00914906,0.084185325,-0.0055168024,0.059067134,0.021508731,-4.0041225e-08,0.0031278804,-0.05247694,0.05239037,-0.011990881,0.06145644,0.04434178,0.08032911,-0.018964114,0.033735428,-0.06674419,0.007307869,0.15987976,0.050696373,-0.060767084,-0.0025092093,0.034461617,-0.03634792,-0.0060396907,0.018149303,-0.020225365,-0.031543218,0.012475422,-0.04598305,0.033426575,0.046972115,-0.09672216,0.033832196,-0.014100716,0.0072145355,-0.020464955,0.02813256,0.014426948,-0.027225045,0.0008215857,0.07085129,0.0119940685,-0.08399615,-0.023383588,0.01006319,-0.037726235,-0.052993406,-0.06428706,-0.057294767,0.0046083718,0.03373758,-0.0039717774,0.020614412,0.008074287,-0.007354847,-0.028897222,-0.009497664,-0.0035300166,0.012523954,-0.104918726,-0.08363167,0.02098944,0.01057062,-0.06969044,-0.019710826,-0.062432017,0.050655764,0.040410917,0.12037198,0.016276345 +1.14.15.7,"The spinach enzyme, which is located in the chloroplast, contains a Rieske-type [2Fe-2S] cluster, and probably also a mononuclear Fe centre. Requires Mg2+. Catalyses the first step of glycine betaine synthesis. In many bacteria, plants and animals, betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. Different enzymes are involved in the first reaction. In plants, the reaction is catalysed by this enzyme whereas in animals and many bacteria it is catalysed by either membrane-bound EC 1.1.99.1 (choline dehydrogenase) or soluble EC 1.1.3.17 (choline oxidase) [7]. The enzyme involved in the second step, EC 1.2.1.8 (betaine-aldehyde dehydrogenase), appears to be the same in plants, animals and bacteria. In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 (glycine/sarcosine N-methyltransferase) and EC 2.1.1.157 (sarcosine/dimethylglycine N-methyltransferase).",384,0.99999994,-0.078864984,-0.08274647,-0.1182619,0.007525099,0.06191283,0.07803341,-0.10121106,-0.024132038,0.047549292,0.007991093,-0.006191068,0.030775767,-0.011678246,-0.01135095,-0.046405125,0.021421866,-0.0464926,0.010043406,-0.012709901,-0.016224192,0.023825837,0.0006425758,-0.067660086,-0.009968171,0.011401918,0.024596876,0.06882204,-0.06551887,-0.04274082,-0.0580395,0.0039632274,-0.066097125,0.071493834,-0.03423264,-0.05846014,0.045905013,-0.014415386,-0.08250196,0.09212156,0.018819856,-0.060915522,0.060886096,-0.023887878,-0.061436657,0.020894073,-0.033371404,0.063402966,0.0047048526,0.04797578,-0.086430706,0.0026111011,-0.03865219,-0.047507778,-0.029192084,0.038964037,-0.002130733,-0.07283385,-0.004927002,0.069142744,0.01231832,0.021015486,0.015662756,0.011892903,-0.036634013,-0.008339434,-0.060467936,-0.0024275887,-0.1288875,0.047527615,-0.09063207,-0.06668685,-0.041269735,-0.026659932,0.013438725,-0.027205791,0.018245509,0.001032713,0.04888401,0.013176903,0.002223309,-0.06531422,-0.061840527,0.03802403,0.04071247,0.04344064,0.053684384,-0.0106265675,0.09092373,0.045432,0.035626743,0.06208144,0.050252676,-0.026843019,-0.0020844152,0.01016089,0.028174402,0.05403854,0.027657028,0.0385106,-0.050985653,-0.051562857,0.0831449,-0.034337614,-0.053743865,-0.005483235,0.035538528,0.061049994,0.09402356,-0.022184812,0.009405473,-0.013360978,0.048695914,0.030664513,0.042875934,0.0002913665,0.05740997,0.044533372,-0.035611674,-0.01761365,0.05853448,0.06324174,0.0016450591,0.009562848,0.074627854,-0.04820866,0.11760657,-0.09176368,3.0795166e-33,0.061295625,0.056227677,0.02350632,-0.028387325,0.026769865,0.01332512,-0.111513436,0.02737557,0.04992272,-0.05154483,-0.012700338,-0.046520967,0.029782835,-0.011439417,0.060379792,0.022014378,-0.0051908214,-0.06046958,0.06963449,-0.010735099,-0.046247628,-0.0017133157,0.008650716,0.019436086,0.09043233,0.011830948,0.03532414,-0.01658789,0.018035252,-0.005688687,0.0020511213,-0.16430947,-0.043997213,0.028521825,0.00851622,-0.008982482,-0.06621456,-0.028590603,0.011580831,0.02681415,0.045091156,-0.017574681,-0.013754112,-0.009404036,0.026470143,0.01123284,-0.023176813,0.085034065,0.033875756,0.047539853,0.030587973,0.0018317536,0.05284701,-0.01117663,-0.02261922,0.058576647,0.031201188,-0.018234015,0.036715474,0.1306113,-0.003798821,0.05077582,-0.016136203,-0.018091004,0.048060577,0.018304467,-0.1110777,-0.041068375,0.0076071764,-0.022608446,-0.045698818,-0.045729943,0.09974388,0.019096138,-0.015931914,-0.028317975,-0.012034119,-0.0041258987,0.04972778,-0.078981146,-0.00536764,0.08741211,-0.0106783295,-0.018171635,-0.014199504,0.012406414,-0.03386346,-0.08054947,-0.020215815,0.023831913,0.031799924,-0.0025752885,-0.052896492,-0.02395621,-0.02325149,-3.3510956e-33,0.08466,-0.12617582,0.024179664,-0.078910835,-0.04165703,0.017063217,-0.048406355,-0.14576522,0.047153037,-0.05111156,-0.048519336,0.01910631,0.036303237,-0.037086457,-0.021423008,-0.024746181,0.047941316,0.04839869,-0.014291718,-0.06904627,0.022224043,0.081184655,0.058366347,-0.035837274,0.03219532,-0.02666191,0.01238793,0.088571765,0.10591648,0.08995248,0.022314992,0.049346633,0.0048884694,-0.052248545,-0.04999185,0.059554435,-0.050954904,-0.012334637,0.08239108,0.02647531,-0.008566376,-0.011284535,-0.056087106,0.0009293747,0.07136649,0.10366294,0.02519112,-0.0010051514,-0.05882041,-0.06554823,0.03931296,-0.049605712,-0.028051123,0.04120361,0.025514903,0.024421299,-0.0102377925,0.030627709,0.07744557,-0.07359725,0.04152994,-0.026822267,0.040334873,-0.014376428,-0.024509318,0.028229872,0.0007195298,0.06583054,0.07171581,0.040061086,-0.018351603,-0.035464328,0.040301304,0.07071666,-0.0052831294,0.0473302,-0.021707555,-0.05557754,-0.015986372,-0.028830217,-0.038795307,0.09809536,-0.06609547,-0.045949694,0.0016468085,-0.037878633,0.028124418,0.1657394,0.024479885,-0.0041596,-0.04077696,-0.008037714,-0.015259018,0.08243429,0.09149781,-4.280618e-08,-0.0042401766,-0.06100081,0.067323156,-0.015326659,0.0021178739,0.045146458,0.053767525,-0.010328161,0.03577447,-0.07125017,-0.089514725,0.059159394,0.004248402,-0.02572808,-0.04478368,0.070289664,-0.03552904,-0.00426737,0.0022957136,0.032709826,-0.04815308,0.019450549,-0.13061057,0.054489024,-0.0067578657,-0.1261894,-0.032970205,-0.013311349,-0.054815263,0.013600073,0.03990681,0.05378173,0.035309132,-0.10533872,-0.0699364,-0.07239016,0.013587387,0.0030640655,0.07833007,-0.016161177,0.01522738,0.008646029,-0.062142882,-0.011360102,-0.013779075,0.003255173,-0.017678661,0.04767476,-0.02571266,-0.011361753,0.079225324,-0.019352576,-0.002888022,-0.096702,-0.10067823,0.04209211,-0.05861667,-0.11069231,0.023329854,-0.0396826,-0.047428086,0.020057498,0.14665641,-0.035455044 +1.14.16.1,"The active centre contains mononuclear iron(II). The reaction involves an arene oxide that rearranges to give the phenolic hydroxy group. This results in the hydrogen at C-4 migrating to C-3 and in part being retained. This process is known as the NIH-shift. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.",384,1.0,-0.04661558,-0.09618721,-0.070685744,0.012800854,0.14332367,0.037389368,-0.026422894,0.019306894,0.025797319,-0.035818007,0.020286534,-0.05768432,-0.08693411,0.0021285093,-0.048963767,0.018452445,-0.095154226,-0.027948149,-0.0018045614,0.0013063155,-0.032842677,-0.09130997,-0.011018933,0.0020250976,0.007886179,0.031773917,0.079702474,-0.03021735,-0.06716917,-0.106133945,0.0019071285,0.060930796,-0.030634465,-0.017228005,0.004328319,0.06342879,-0.045201123,0.0074096695,0.054864883,0.032922104,0.010270075,-0.08559756,0.010922316,-0.03526792,-0.016420364,0.014106066,0.040486686,0.10143938,0.032156702,0.03762826,0.004043188,0.027564056,0.015716659,0.07650045,0.04102006,-0.013279306,-0.02220399,0.015195943,0.04226817,0.048847325,0.122946456,-0.0024535707,-0.006456989,-0.032160413,-0.005525458,-0.05919726,0.04993,-0.063489914,0.037929613,-0.11789237,-0.056089316,0.009059743,-0.00037493923,-0.0012984228,-0.019419305,0.04054879,0.03710001,-0.009115948,0.0561385,0.027062235,0.021588907,0.054119706,0.053639248,0.05568704,0.04427876,-0.021545293,-0.047081195,-0.033160213,-0.022929102,-0.011166244,0.0027371005,0.013852363,-0.023396598,-0.010475096,-0.07075106,0.106211334,-0.0027883637,0.010841949,0.078982964,0.020734992,-0.050662782,0.047215525,-0.06148646,-0.041110545,-0.019063616,-0.053847622,0.03642328,0.14701769,0.016735205,0.042922303,0.013029949,-0.03046427,0.04985584,0.056718644,-0.027344648,0.03331019,0.015075549,-0.022155443,-0.071241856,-0.017509492,0.019483756,0.07765713,0.057190876,0.009215773,-0.04197987,0.08377998,-0.10868273,5.446254e-33,0.062237717,0.0014269169,0.07101406,0.055256013,-0.012979264,-0.025925385,-0.1262849,0.0275203,0.019404411,-0.05119705,0.0010220447,-0.08583713,0.10183438,-0.018472206,-0.069369696,-0.13929783,0.0091488855,-0.029496865,0.038143408,-0.048022266,0.0026508383,0.14118055,-0.056520272,0.0038788498,0.03403636,0.04664012,-0.061877664,-0.048708275,0.11150181,-0.02142173,-0.04418887,-0.03166358,-0.08440672,-0.0044281473,0.058382727,-0.018763067,-0.048910104,-0.0072838007,-0.011402375,0.04838738,0.029779702,0.023100043,-0.049720377,-0.09346044,0.06761755,-0.017011292,-0.01209909,0.096168004,0.00032679964,0.031216191,0.056016773,0.03389836,0.052103955,-0.025055204,-0.063589595,-0.01708858,-0.0047113006,-0.011193714,0.09446473,0.01005566,0.03936406,0.059757102,-0.04709895,0.0033030366,0.045039974,-0.055917807,-0.08060238,0.0060519553,-0.013008729,0.035623867,-0.05860134,0.020731634,0.10913998,0.006712753,0.031011939,-0.03307503,-0.12563086,-0.041967575,0.052743457,-0.083706476,0.024339829,0.07236223,0.080667354,-0.002507691,-0.047415353,0.024160428,-0.056893203,-0.03738516,0.010654069,-0.007348438,0.0059949034,-0.085423164,-0.06461508,-0.059950233,0.05429965,-4.6938562e-33,0.070619054,-0.03521936,-0.03724278,-0.016296724,0.06924022,0.04284207,0.050644714,0.00417593,-0.010655186,-0.0677113,0.112551086,-0.003002022,-0.037869945,-0.015773527,0.03293903,0.028983237,-0.005090696,0.05188973,-0.0039886637,-0.0023753173,0.056331217,-0.023347484,-0.07211353,0.019781526,0.054869715,0.021852426,0.036868993,0.028649768,0.117817976,0.072383046,-0.037276693,0.014747884,-0.028239537,-0.011947425,0.04638067,0.023895029,-0.13948293,0.006513331,-0.0115633495,0.04154984,-0.014716076,-0.08953914,0.034859374,0.043945204,0.055383123,0.07325525,-0.0805986,0.04933815,0.03344598,0.051089246,0.040980764,-0.05497529,-0.080203645,0.031908575,0.023559405,0.032867853,0.113855466,-0.008389587,-0.014913182,0.027215246,-0.042914115,-0.06394238,0.05907648,-0.056361035,-0.0014136995,-0.005864967,-0.03132293,0.10360135,0.03896002,-0.09259397,0.055262838,-0.032240678,0.0383641,-0.04828866,0.0321777,-0.102903046,0.018332751,5.392085e-05,-0.01310674,0.021525178,-0.039665367,-0.049548298,-0.0008453354,-0.052458294,0.041993823,-0.01109277,0.04759557,-0.012716524,-0.033941623,0.024233095,0.005628659,-0.048024163,-0.006839081,0.036562048,-0.00036503258,-5.0302514e-08,0.05209648,-0.10968507,0.06475995,0.01085179,0.036069423,0.040600866,0.06875746,0.004824506,-0.01959188,-0.10408853,0.01753189,0.029774517,0.048198454,-0.00512138,0.06573848,-0.012268822,-0.015359867,-0.042459823,-0.039610066,0.006274632,-0.08463066,-0.06424232,-0.07445237,-0.0008010674,-0.028356036,-0.05897462,-0.03488311,-0.025618639,-0.0015550056,-0.05573792,0.037027445,0.093160555,0.03318013,-0.00046489076,-0.058244303,0.0072745103,-0.009319579,0.022314332,-0.0280196,0.0029566803,-0.02655833,-0.02212634,-0.102179796,0.008792319,-0.013977685,-0.05237923,-0.0570975,0.06791612,-0.02650427,0.041692927,-0.015110094,0.047929704,0.04318308,0.021533052,-0.037879925,0.061784137,-0.011593065,-0.04438891,0.019951139,-0.056710098,-0.01367171,-0.028999494,0.08126828,0.053440455 +1.14.16.2,"The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.",384,1.0,-0.041857578,-0.10414701,-0.11315411,0.0066316794,0.1284193,-0.0057292706,-0.038181197,0.029097112,0.020197077,-0.032008152,-0.010256794,-0.019906266,-0.053751305,0.025581669,-0.046894867,0.016399274,-0.091356054,-0.014422664,0.015477704,-0.009146434,0.0022406478,-0.06757951,-0.019800104,-0.0006100194,0.020012565,0.029010748,0.097494155,-0.016542364,-0.10627689,-0.09930464,-0.005940351,0.009822343,0.0023129436,-0.0328054,-0.0025009753,0.08175004,-0.057540517,-0.01099538,0.019147282,0.0326242,0.019173676,-0.08208365,-0.027850928,-0.07514035,-0.034226947,-0.019590389,0.042322695,0.104612835,0.022255464,0.08299902,0.017693466,0.028271254,0.031974796,0.059240308,0.06337678,-0.029337946,-0.015782483,0.009539419,-0.012481805,0.019849442,0.09054983,-0.049757738,-0.008930597,-0.02578885,-0.011629954,-0.057447832,0.07082793,-0.03709778,0.009945187,-0.12331342,-0.08464586,0.018370377,0.017165545,0.036785465,-0.0155919315,0.026146337,-0.0007402373,-0.028361185,0.063729525,0.0442591,0.010002117,0.015020786,0.050171807,0.09849507,0.053650953,-0.00579244,-0.020010918,-0.01343017,-0.022473799,0.009421571,0.07720759,0.027669039,-0.024353262,-0.016138738,-0.08504252,0.11404806,-0.0191597,0.031259682,0.0055215675,-0.0015919424,-0.060819995,0.022262024,-0.05797988,-0.03449795,0.0073593496,-0.05477507,0.038056947,0.14176178,0.017034447,-0.007501052,0.008813829,-0.039215215,0.074191034,0.07665823,-0.0064853583,0.08281287,0.021918453,-0.0476724,-0.05154673,-0.011619397,0.033338886,0.0751592,0.07281089,0.030724857,-0.0072033345,0.075406484,-0.1519532,7.6000735e-33,0.024833465,0.023081152,0.076356225,0.054233138,-0.014858952,-0.014131378,-0.10028225,0.036514696,0.020304598,-0.033203386,-0.009922664,-0.08047524,0.11446272,-0.00788745,-0.04009708,-0.12006035,0.0151798185,-0.04447632,0.0343606,-0.03324152,0.07655362,0.12209791,-0.03877194,0.005920893,0.042689435,0.052887216,-0.053824674,-0.0084675765,0.085858755,0.0059528304,-0.049524087,-0.08780401,-0.060525328,0.032046597,0.075184606,-0.036385823,-0.06312068,0.015536705,-0.02712439,0.05454479,0.047139034,-0.009115619,-0.05002234,-0.072398104,0.04949867,-0.038097143,-0.024427304,0.108148344,0.017756086,0.048171397,0.049699668,0.036553208,0.08612892,-0.037958268,-0.056583207,0.010271798,-0.041471526,-0.025150578,0.07129119,0.04620616,0.03873433,0.05032954,-0.058783635,0.015061218,0.036338598,-0.050377663,-0.07016619,-0.008661052,-0.010644986,0.032014195,-0.04553138,0.05861503,0.12756407,-0.008494262,0.034996558,-0.04351193,-0.08292592,-0.0032584504,0.018146206,-0.015069813,0.011168329,0.027946346,0.03100488,-0.013377057,-0.07027063,0.009476932,-0.029886225,-0.0545209,-3.803341e-05,-0.0066848774,-0.009329435,-0.07314147,-0.079875074,-0.059945725,0.074029826,-6.597792e-33,0.10433203,-0.042089116,0.034627695,-0.009243027,0.026463386,0.06809892,0.0753277,-0.03466717,0.019914119,-0.052362766,0.091980614,0.029911462,-0.06169639,-0.024491677,0.0640218,0.05129877,-0.031082455,0.07105918,0.019507542,-0.035919756,0.0039137164,0.0053601163,-0.027424851,0.00452647,0.07352591,-0.022010913,0.023734609,0.04052042,0.09815325,0.052931014,-0.040437415,0.030811232,-0.017235627,-0.028821146,-0.02453273,0.010645195,-0.13313106,-0.038928945,-0.016792476,0.02655259,0.002360009,-0.07920463,-0.016579209,0.03974463,0.07461196,0.03321789,-0.06947342,0.04235372,0.038157567,0.00075729267,0.037245058,-0.046548866,-0.05757781,0.063046224,0.0700103,-0.015089615,0.1282977,0.041205913,0.012560983,0.048909795,-0.04910377,-0.067287125,0.0392697,-0.001446539,-0.0027495965,0.00082266127,-0.023497945,0.1268276,0.033549815,-0.015433758,0.03908691,-0.023819707,0.013877439,-0.031358562,0.023387248,-0.042914852,-0.038070295,0.045101732,-0.035309047,-0.021295832,-0.036726642,-0.055097234,-0.038042046,-0.06739821,0.019829864,-0.0024906925,0.05346393,0.0010954419,-0.05695345,0.019295448,-0.029254204,-0.08563806,-0.019158969,0.055276524,-0.02791899,-5.306047e-08,0.016599238,-0.10866387,0.041250244,-0.05429069,0.07806615,0.03850287,0.08617852,0.017516442,-0.019567017,-0.08766692,0.018829396,0.011491369,0.05252295,0.0140268905,0.08385875,-0.016889548,-0.008005943,0.009944742,-0.02388562,0.016134404,-0.028315153,-0.075202756,-0.12143447,0.03128834,0.012102394,-0.05224507,-0.04277401,-0.018170733,0.022048077,-0.06833491,0.03987222,0.039450105,0.0077657257,-0.039470106,-0.086958736,0.010049498,-0.068216614,-0.0067022247,-0.042172197,0.043468423,-0.01692716,-0.02598645,-0.06424635,-0.0032059683,-0.01194397,-0.027937487,-0.012754899,0.045344163,-0.004425162,0.004401554,-0.019858474,0.056387298,0.0273324,-0.01620639,-0.054174863,0.08944238,-0.0008824905,-0.0741138,0.0025776823,-0.05463244,0.021421256,0.00013514399,0.08514952,0.010152962 +1.14.16.3,Requires Fe2+. The enzyme has been characterized from the leaves of the plant Tecoma stans (Yellow Bells).,384,1.0,-0.03916481,-0.05976174,-0.11076834,0.09275697,0.088958815,0.058497224,-0.016394364,-0.0013603372,-0.0058418764,-0.008421677,0.026072124,-0.06828711,-0.09917145,-0.015134367,-0.055552218,-0.0123207355,-0.02527382,-0.0045715375,0.013211172,-0.04545776,0.03649103,-0.00861041,0.068485625,-0.03119947,-0.0674463,0.02801807,-0.027556287,0.00466279,0.029517252,-0.0712614,-0.046171628,0.053348657,0.034189325,-0.08798256,-0.05315768,0.08709433,-0.0359979,-0.10276837,-0.0024635901,0.018045275,0.007288275,-0.021557227,-0.028516,-0.05086207,-0.033845264,-0.08972195,0.06249389,-0.041257873,0.056167357,0.022418335,-0.029184869,-0.0003871855,-0.020407261,0.038167264,-0.021263655,0.031097839,0.034627344,0.01838874,-0.018168006,0.05732117,0.036173195,-0.020840371,-0.031113623,0.02154059,0.0105580725,-0.0058384906,-0.02132387,-0.013414438,0.061289616,-0.051353496,-0.016225498,0.0075117354,-0.028945364,0.011989622,-0.03900383,0.043907795,0.098599546,-0.061723888,0.038822666,0.04940893,-0.05975468,0.039821807,-0.022331048,0.06269788,0.09190796,0.10302888,-0.050836142,0.02222052,-0.022035126,0.10310682,0.09474261,0.044968918,-0.034266494,0.015793294,-0.030402098,0.02788288,0.025940938,-0.05196037,-0.034009222,-0.029127672,-0.088996425,0.053981945,0.0020303724,-0.057536177,-0.027889159,0.034941785,-0.065165706,0.033111777,0.046867996,0.034521703,0.04153651,-0.0373901,0.0543263,-0.019884642,0.004983618,0.043814432,-0.019809822,-0.08379689,0.015859736,0.05392144,0.110785045,-0.044451676,-0.059775904,0.07684542,-0.069509424,0.039888468,-0.11077282,-1.4399422e-33,0.069830485,0.09632871,-0.015516786,0.029184613,0.0009973218,0.0090857055,-0.09176149,-0.043890968,-0.044762723,-0.017091356,-0.09262087,-0.094355226,-0.007276192,-0.048846643,0.0043180147,-0.065258026,0.01736952,-0.06757098,0.07318605,0.025033038,-0.008312041,0.09262848,-0.034963448,-0.03534769,0.03783989,0.0633663,-0.030558642,-0.021436619,0.06559506,0.0047928696,0.077592395,-0.08312137,-0.038811043,0.031984415,0.0876171,-0.033212304,0.011001236,-0.01551802,-0.007826917,0.027287288,0.07265839,0.078449726,0.016112745,0.020511487,0.07487004,-0.103833854,-0.030774893,0.12710564,0.10194742,0.102180265,0.057274003,0.033245005,0.071961366,0.03233502,-0.07565046,0.029014893,-0.023074526,0.009513696,0.06652695,0.075095996,-0.02521529,0.0033293846,0.050708186,0.057823278,0.03796255,-0.0150411595,-0.12681586,-0.0038187383,-0.008333674,0.04072038,-0.07627566,0.00024693654,0.07002571,-0.015665358,0.07207287,-0.036676772,-0.023465225,-0.011667572,0.07091079,0.02417216,-0.0028186801,-0.0017633516,0.003290836,-0.023307692,-0.05130868,-0.032101378,-0.05773838,0.032385673,0.009585142,0.017740829,0.060448125,-0.01534491,-0.048672456,-0.0059923767,-0.019459264,1.8047599e-34,0.044302065,-0.03454182,0.077163674,-0.07970473,-0.069142744,0.062425442,-0.036016565,-0.12326172,0.004876022,0.05011882,0.074667305,-0.008669696,-0.0039621894,-0.06490138,0.0012573028,0.04987799,-0.033063877,0.11970127,0.0013065842,-0.048935723,-0.07752432,0.058883157,-0.0084087765,-0.023440145,0.0186537,0.017042696,-0.03870716,0.024079904,0.031150484,0.021070212,0.010384529,-0.052747786,-0.09828162,-0.024637468,-0.053872384,-0.014812432,0.015496442,-0.03273687,0.07956702,0.088885486,0.04792309,-0.005469544,0.034032498,0.07430475,-0.037836216,0.017359173,-0.018881219,0.021924382,-0.042360842,0.027925832,0.04419214,-0.031453207,-0.103450894,0.0075089573,0.034611017,-0.022539837,0.060302913,-0.0115480535,-0.0726308,-0.013228193,0.04634522,-0.04037577,0.06266683,0.0016965773,0.027541736,0.057809673,0.009766854,0.12249225,0.053756166,0.029507566,0.04278507,0.090543106,0.045027185,-0.0428506,0.002027528,0.007908429,-0.07222031,-0.022817284,-0.040301636,-0.054372214,-0.00110199,0.039205305,0.012885067,-0.07582448,0.02082956,-0.0639878,0.023075525,0.050599597,0.015415924,0.0011797979,-0.035200525,-0.013801563,-0.0043374384,0.04944005,0.08334127,-2.455808e-08,-0.08398941,-0.118057854,-0.006847643,-0.0958065,0.00724486,0.028460145,0.017778168,-0.07213004,-0.0020927975,-0.03662123,0.005487606,0.10053344,0.0042632464,0.011055723,0.025750654,-0.019522367,0.0035521754,0.044781957,-0.0214854,0.0070777605,-0.06200856,0.005969886,-0.10246288,0.025542345,-0.023907242,-0.06382606,-0.011320132,0.0639016,0.02231871,0.0116019575,-0.019634986,0.013639287,-0.050543208,-0.06619605,-0.09614255,-0.033128813,-0.0031688947,-0.038044587,-0.12568787,-0.01424218,0.025280086,0.028662905,-0.030498708,-0.007279823,-0.030583937,-0.045219645,0.00026528316,0.060020242,0.039131887,0.0019177157,0.04445849,0.0076069203,-0.0035941557,-0.05556848,-0.10183143,0.02039741,0.021332882,0.020604085,0.022161795,-0.075918384,-0.009253188,0.0074240966,0.12131407,-0.048105653 +1.14.16.4,"The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by a Ca2+-activated protein kinase. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.",384,0.99999994,-0.031720687,-0.12414715,-0.11038243,0.016184364,0.11942077,-0.015887324,-0.029524105,0.032011706,0.033472415,-0.03421626,0.011495465,-0.012986601,-0.031679828,0.026177686,-0.03591773,0.023669314,-0.10054673,-0.021017762,0.024983205,-0.020424364,0.009045115,-0.08019469,-0.036327284,-4.2881587e-05,0.020047836,0.0132546285,0.08496237,-0.022675076,-0.11935908,-0.08930605,-0.002675669,0.015496259,0.004171899,-0.021577314,-0.0008933476,0.0934671,-0.062803224,0.0012974137,0.035526812,0.01813026,0.01639278,-0.06238945,-0.0040996433,-0.059149597,-0.044775676,-0.0024933268,0.032174133,0.107253864,0.034119997,0.06619581,0.020875571,0.050101988,0.045802336,0.050262947,0.060146175,-0.018747399,-0.02153915,0.00965284,0.0062107192,0.031090604,0.1015406,-0.027232165,0.00043584706,-0.028704712,0.006548216,-0.057643045,0.04878243,-0.036542285,0.02344963,-0.1301978,-0.078007326,0.010666421,0.01971996,0.032979637,-0.022665039,0.023990573,-0.00963852,-0.017899424,0.056546133,0.04622462,0.0076033645,0.009042566,0.056465507,0.08905743,0.04611013,-0.007117259,-0.0067710783,-0.036494665,-0.024284845,-0.0038331388,0.068696804,0.02343365,-0.026317421,-0.021881584,-0.074743636,0.09505017,-0.022473194,0.01805211,0.0059031667,-0.00868125,-0.04459854,0.0021879338,-0.047870323,-0.03215592,0.00088006555,-0.0825535,0.053295195,0.13980384,0.013407169,-0.0066361884,0.026922783,-0.029815245,0.07235591,0.08376997,-0.007276402,0.091026515,0.02442253,-0.052104916,-0.08042262,-0.019172331,0.021212786,0.056703135,0.06686458,0.009987763,-0.009216965,0.065117,-0.13835366,6.648013e-33,0.013618811,0.014675842,0.07840405,0.0412253,-0.003842095,-0.030422466,-0.08675493,0.044500574,0.02716246,-0.025846297,-0.005887096,-0.079209805,0.10767074,0.0123449555,-0.061909504,-0.13309918,0.015449894,-0.05304648,0.054581597,-0.019518977,0.06443737,0.13241825,-0.039071474,-0.0007667506,0.043901768,0.049656786,-0.052859034,-0.02568506,0.08729169,0.00063975994,-0.07011117,-0.088595994,-0.067234606,0.037444174,0.067087,-0.029607872,-0.05633145,0.0072932374,-0.028487686,0.04845924,0.06180923,-0.0030561667,-0.024857104,-0.07767479,0.051151864,-0.004033596,-0.034055516,0.10060948,0.0036650375,0.061815944,0.056459557,0.044200674,0.08607542,-0.03540143,-0.047379598,-0.0042775823,-0.03290973,-0.03352428,0.06140083,0.05399407,0.050053343,0.033926405,-0.065534376,-0.0042832033,0.025729846,-0.061726533,-0.042938184,-0.017251568,-0.0041050618,0.027118782,-0.05741149,0.051750183,0.12213304,-0.0063041705,0.039148115,-0.038209394,-0.09097668,-0.0038952043,0.024877563,-0.018454982,0.008960064,0.033624984,0.04991257,-0.0035198303,-0.052445143,0.017133126,-0.03716671,-0.047787197,-0.0044453037,-0.027433114,-0.0147600835,-0.070536055,-0.08382081,-0.039504375,0.08038682,-5.757108e-33,0.100739405,-0.051556095,0.04011452,-0.00093477505,0.053034857,0.06393704,0.06920161,-0.010189963,0.025661383,-0.04981883,0.096052,0.02517642,-0.059672333,-0.03098661,0.06366076,0.06882904,-0.023829753,0.07309292,0.01817778,-0.02735229,0.0043210415,-0.004383482,-0.019231256,0.0010170707,0.08435261,-0.010840359,0.040154662,0.034664724,0.09222374,0.04998018,-0.04109733,0.03415207,-0.01418319,-0.027540851,-0.046307426,0.012117883,-0.12867133,-0.03930951,-0.026732251,0.031023463,0.0064410553,-0.074726045,-0.0061619855,0.048451047,0.062402554,0.019618716,-0.060721684,0.0489388,0.03663632,0.011760356,0.053662024,-0.060018025,-0.046768717,0.055905305,0.056835916,-0.010030465,0.1419521,0.053606972,-0.018424215,0.048325118,-0.06309449,-0.06901923,0.024207963,-0.004007254,-0.022681924,0.016477834,-0.014164323,0.10812706,0.030961428,-0.032042406,0.03325342,-0.042814642,-0.0030187413,-0.033868425,0.013799677,-0.038063753,-0.03609368,0.03889536,-0.02026991,-0.0006735025,-0.049979426,-0.0507868,-0.038633913,-0.073583566,0.042326897,-0.004434104,0.052319292,-0.013608209,-0.06339321,0.039211776,-0.021067865,-0.09219312,-0.005190037,0.03692433,-0.017450435,-4.9072735e-08,0.026161911,-0.103021786,0.029040068,-0.05655447,0.06989694,0.044588342,0.077108786,0.020587431,-0.021929331,-0.08384007,0.02983585,-0.0025044568,0.025164345,0.0021148028,0.088973545,-0.0013253483,-0.00093783304,0.008823824,-0.03199384,0.022187056,-0.02388717,-0.07111334,-0.14158624,0.033201788,0.014043881,-0.038264286,-0.053211216,-0.0190064,0.016542556,-0.049342502,0.050088707,0.047898598,-0.017651219,-0.05628823,-0.08522551,0.0036874418,-0.06136772,-0.029141651,-0.038176723,0.031087609,-0.030408474,-0.0152783785,-0.0640887,-0.012464113,-0.033062577,-0.016279558,-0.04446909,0.03630407,0.002408195,0.025790207,-0.009576808,0.042413656,0.03812149,-0.017964168,-0.06638604,0.09830692,0.014279502,-0.07879679,-0.009101096,-0.05321127,0.025276631,0.0066046766,0.10498128,0.013280887 +1.14.16.5,"The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens). Requires non-heme iron [7], reduced glutathione and phospholipids for full activity. The product spontaneously breaks down to form a fatty aldehyde and glycerol. The co-product, 4a-hydroxytetrahydropteridine, is rapidly dehydrated to 6,7-dihydropteridine, either spontaneously or by EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase.",384,1.0,-0.023665028,-0.0825882,-0.072045095,-0.022262458,0.07625776,-0.01800027,-0.047858205,0.016238114,0.024302108,-0.05392149,0.030763377,-0.060642842,-0.07486544,0.030900454,-0.037049018,0.0011392555,-0.01943081,-0.07635021,0.004332852,0.013315481,0.03748093,0.008419361,-0.013009058,0.047884427,0.06834885,-0.0050638304,0.064117335,-0.07262087,-0.04954709,-0.022633001,0.050698217,-0.06791372,-0.03433841,-0.024027552,0.056869637,0.043278325,-0.014797481,-0.0076463097,-0.005384467,0.093882665,0.026612468,-0.06680231,-0.086914904,-0.020248892,-0.00018277313,-0.046827022,-0.03592046,0.070119895,-0.029102245,0.13625683,-0.023689087,-0.0030824426,0.016556727,-0.0070906924,0.08057539,-0.0625721,-0.07264154,0.036133878,-0.024762161,0.044503912,0.050088916,0.022259854,-0.0041106124,0.011041516,-0.02464683,-0.12449276,0.035092965,-0.016043264,0.051282417,-0.062322024,-0.06608428,-0.039570723,0.022600813,0.054135185,-0.007984161,0.033210985,-0.0656615,-0.07588024,0.023486296,-0.033554256,0.013465676,0.022267776,0.02788448,0.14037344,0.028280495,-0.029415643,0.009921405,-0.0031028804,-0.0012296017,-0.03709788,0.029900147,-0.031372126,-0.021679653,0.028177492,-0.094157785,0.101434134,0.011922482,-0.0003912514,0.00424886,-0.00682556,-0.06546906,0.005521627,-0.002179943,-0.05459312,-0.05711791,-0.02680369,0.02409267,0.09265191,0.03023072,0.02195287,0.039930303,0.0002824535,0.061108958,0.04670658,-0.0053994143,0.062181707,-0.0024361045,-0.046962455,-0.051380113,0.02181115,-0.031268142,0.0113538075,0.096445315,0.05893364,-0.00013325972,0.1341353,-0.043738108,5.878534e-33,0.046097454,-0.017081153,0.021970203,0.0056776567,0.019204237,-0.011348932,-0.11893327,0.06824818,-0.062211532,-0.039760917,0.017550418,-0.043014284,0.06404167,0.035618808,-0.009490766,-0.040229212,0.01962568,0.01283023,0.12069762,-0.0029565692,0.025870692,0.0518635,-0.031475596,0.0076219905,0.016850824,0.055865724,0.0005424037,0.021867417,0.06220382,0.011006547,-0.06358038,-0.086059675,-0.028799834,-0.07052961,0.07653805,0.007876683,-0.060097232,-0.042435706,-0.034835055,0.013328213,0.03131065,-0.017298916,0.0097227385,-0.08785132,0.068941735,0.007463127,-0.07252266,0.1065564,-0.051775306,0.0081568565,0.056459986,0.030023506,0.103764884,0.026130283,-0.0764316,0.0056009092,-0.03797839,-0.04813188,0.060586076,0.055416856,0.015706588,0.13423012,-0.060330555,-0.03362333,-0.054610793,-0.09927216,-0.049310964,-0.005723322,-0.039539445,-0.0073997974,-0.008479119,0.0053092553,0.04712474,0.0032724184,0.0439925,-0.06262076,-0.017793622,0.029262032,0.0037189557,-0.037176646,0.059474986,0.030520817,0.070131384,-0.022952989,-0.0650361,-0.003067648,-0.090365164,-0.05069794,-0.019365875,-0.0077400124,-0.073967434,-0.03952923,-0.057155676,-0.010821962,-0.0070220875,-6.365449e-33,0.066693306,-0.096351944,0.08809917,-0.07055178,0.056155756,0.08308005,0.025122093,-0.012235192,0.050553154,-0.07797521,0.10096146,0.0014551524,-0.04324691,-0.04245815,0.03622007,0.08823963,-0.06835108,0.02903743,-0.017293554,-0.07941218,0.05581625,0.04496111,0.0039539617,0.08506541,0.0624764,-0.02220746,0.036182657,0.043641213,0.047269087,0.07130617,0.042188764,-0.004235327,-0.07358139,-0.06967518,-0.04281058,0.034356467,-0.116097264,0.03770603,-0.052016385,-0.02410726,-0.030669158,-0.039738342,0.026714383,0.013135538,0.07345589,0.02513429,-0.043502484,-0.040643908,0.06919693,-0.013973881,0.039979998,-0.05679584,-0.022551246,0.08748527,0.021344768,0.06279571,0.03200201,0.043219853,-0.0071808007,-0.043911934,-0.06431448,-0.029965766,0.04768256,0.010677007,0.03716522,-0.014105417,0.011334946,0.037278745,0.057175975,-0.027123341,0.07474862,-0.0006429,-0.04501083,0.025398,-0.008187572,0.030923717,-0.04074457,-0.035725392,-0.03974122,-0.00064734055,0.011379442,-0.014333383,0.028117746,-0.06087316,0.006154663,-0.022579418,0.005080324,0.0107635325,-0.06888809,0.10535652,-0.021279847,-0.03891703,-0.032337025,0.009643887,-0.013897422,-4.820142e-08,0.032805286,-0.081142366,0.030399302,-0.04009009,-0.01806494,0.0039131483,0.09337246,0.00026321114,-0.011106786,-0.05800405,-0.0071046622,0.01971564,0.0008707027,0.074528635,0.061837632,-0.01848453,0.0077704084,0.022613265,-0.018643118,-0.03230454,-0.038737454,-0.023015987,-0.045023598,0.089345515,-0.051541988,-0.073229656,-0.0033397656,0.001505714,0.0588136,0.004927366,0.0023209492,0.074649885,-0.022476392,-0.014263114,-0.0017169378,0.012062049,-0.06327389,0.02346819,-0.08973624,0.107590444,-0.01450311,-0.019458571,-0.013703715,-0.018766379,0.015711006,-0.0622398,-0.03208031,0.026616395,-0.0038272035,0.06586099,0.062205106,0.047729906,-0.013801978,-0.017850801,-0.110318966,-0.033666767,-0.053441923,-0.11955917,-0.018462146,-0.09654391,0.05071669,-0.049673747,0.20867391,0.07033674 +1.14.16.6,"Requires Fe2+. The enzyme has been characterized from the bacterium Pseudomonas putida. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.",384,0.9999999,-0.057484716,-0.103880614,-0.08012848,-0.00905942,0.09854162,0.010179798,-0.057774063,0.03653977,-0.0035078814,-0.042866457,0.008683945,-0.02180302,-0.06253193,0.06558131,-0.08438219,-0.0034863455,-0.10170819,-0.016088277,0.02122217,0.011512025,0.027864875,-0.026938915,-0.04509307,0.0052295183,0.045586556,0.03597074,0.0828676,-0.04233746,-0.08122423,-0.080864035,-0.02094895,0.01616679,-0.0027453594,-0.06418918,0.022468284,0.08794436,-0.010917807,0.031987023,0.07327715,0.032810252,-0.021233018,-0.072123036,-0.0068018553,-0.056181084,-0.049664017,-0.024590574,0.085790865,0.1058029,0.034832675,0.03405247,-0.0014897923,0.054530688,0.05052739,0.03854512,0.069919325,-0.026070148,0.008991473,-0.014705635,-0.034096073,0.017311996,0.07072742,-0.008468377,0.0035501835,-0.01109627,-0.010352127,-0.04634595,0.024825107,-0.031919647,0.029660307,-0.08835989,-0.05458781,-0.004228126,0.05390596,0.044976406,-0.027020385,0.015267469,0.034002528,-0.011481785,0.061295006,0.032287624,0.014896083,-0.021684371,0.020709326,0.08521038,0.030885346,-0.060245723,-0.0055632023,-0.005622078,-0.0026377097,-0.0012774486,0.04898542,0.03129784,-0.039746355,-0.046165816,-0.072031416,0.10501702,-0.039330546,0.017892452,0.029073052,-0.024203831,-0.05400525,0.001994035,-0.02976592,-0.021766195,-0.012390148,-0.09370258,0.049785122,0.13940723,0.02550351,-0.013054124,0.042230368,0.0011649147,0.053335484,0.085152425,-0.026512504,0.042053327,-0.0008870118,-0.06813746,-0.0816255,-0.02742244,-0.006816798,0.05006991,0.06675538,0.044975366,-0.013302857,0.044753786,-0.14714397,6.9324346e-33,0.027585171,0.010898421,0.056078825,0.004576715,-0.0033431326,-0.0074798004,-0.10734414,0.057383947,0.043361716,-0.031053606,-0.013447612,-0.1162075,0.06902296,-0.02080227,-0.02842562,-0.09971912,-0.012622727,-0.038060118,0.05882117,-0.029965153,0.068242215,0.098907515,-0.050515056,0.0056885104,0.08401768,0.057350315,0.00051934435,-0.036235362,0.099719875,-0.0029914204,-0.023630084,-0.078195795,-0.06662883,0.01761783,0.075119436,-0.047826402,-0.06936512,0.011516678,-0.020457229,0.051336937,0.07032648,0.043623004,0.0027439017,-0.07824063,0.069594815,-0.02206227,0.009754623,0.1399553,-0.0043848255,0.0969975,0.03682022,0.015111143,0.07029445,-0.012602619,-0.052619494,-0.015044304,-0.017909737,0.0054949154,0.075632356,0.033528227,0.04188424,0.07382058,-0.05232612,-0.029950352,0.0050816704,-0.0819543,-0.028629899,0.016433021,-0.0035287382,0.009900298,-0.08119635,0.0468223,0.06688485,-0.008527968,0.038294196,-0.07350256,-0.09637267,-0.024886463,0.08308853,-0.064031236,0.013902355,0.0070829117,0.055383,-0.025842257,-0.042557776,0.027195225,-0.05007283,-0.018185336,-0.017113423,0.00574878,0.014807395,-0.10393869,-0.093141615,-0.038181253,0.08486381,-5.83119e-33,0.06192703,-0.083643325,0.046231054,0.00810456,0.063398235,0.05017664,0.0255261,0.028629702,0.02475237,-0.06974463,0.058714777,0.034706436,-0.017274918,-0.036566082,0.040575385,0.057006273,-0.039672066,0.034343705,0.020268662,-0.022088265,0.026129534,-0.00788874,-0.030040836,-0.008412543,0.077217326,0.01735988,0.048164576,0.050624933,0.092434816,0.050402857,-0.002161085,0.050387852,-0.03333069,-0.03189897,-0.023682857,0.014429202,-0.124170355,-0.023698214,0.0071385605,0.023770206,0.006431127,-0.032225974,-0.0038775525,0.03673233,0.02314708,0.024854422,-0.06005662,0.019824881,0.07656408,-0.016591955,0.038777538,-0.061133716,-0.047995824,0.016554518,0.024430806,-0.051438272,0.12318466,0.03205486,-0.033878148,0.032001585,-0.03496073,-0.09768348,0.020319296,-0.0003329976,-0.012589599,0.0014207683,-0.021489257,0.14535893,0.020291304,-0.038428646,0.037656724,-0.06083409,-0.009875229,0.012331336,0.01155609,-0.04985243,-0.036070812,0.037201896,0.037697807,0.025426086,-0.014536332,-0.03261863,-0.050271906,-0.08091734,0.06540433,-0.03203362,0.068548866,0.018492002,-0.07532973,0.05859703,0.004531981,-0.0386626,0.010520772,0.042875696,-0.029741244,-4.516913e-08,0.04041502,-0.14591362,0.066977546,-0.027086928,0.07868932,0.02711476,0.053837854,0.029369542,-0.009036167,-0.12978502,0.01794906,-0.002233409,0.03115973,0.029605664,0.08200593,-0.0329803,-0.034677584,-0.03832181,-0.038956106,0.013313392,-0.04705597,-0.08065144,-0.17025466,0.050788615,0.018456988,-0.016387012,-0.025822982,-0.018194973,0.016164701,-0.047121987,0.023739059,0.040417094,-0.03663125,-0.040292364,-0.088313214,0.026522916,-0.03549807,-0.030453539,-0.02804889,0.007738545,0.006343165,0.000493526,-0.06916488,-0.008724991,0.016868215,-0.020360077,-0.050206922,0.03932784,-0.012441003,0.010010619,0.007699436,0.02330458,0.0371622,-0.009591966,-0.05653345,0.08416349,0.00929391,-0.06313071,-0.016786756,-0.020542651,0.016171033,-0.002655233,0.11912085,0.03549315 +1.14.17.1,"A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.",384,1.0,-0.06630866,-0.012905486,-0.040936787,0.06911931,0.036061212,0.04896568,-0.005321889,-0.0024613354,0.06271583,-0.058965094,0.046212733,-0.084562875,-0.06068267,-0.027538776,-0.06786087,-0.043942258,-0.022942223,0.0016258152,-0.046386696,-0.043533094,0.010909379,-0.016329821,0.011428868,-0.039621674,-0.073291264,0.06351056,-0.012686453,-0.028229542,-0.019533344,-0.05322877,-0.02589945,-0.03903964,-0.040834934,0.097013265,-0.027422527,0.011134083,-0.07169395,-0.026860615,0.003248795,-0.030755695,0.09294591,0.02859783,0.06542496,-0.007926829,-0.017903883,-0.04629613,0.087616265,0.035791084,0.03000464,0.079253204,-0.030293489,-0.02107947,-0.022458335,0.041423578,0.048156776,0.011920034,-0.0027129708,-0.059102055,-0.053798247,-0.042087734,0.067290515,0.012890851,-0.03826291,0.061327033,0.040495977,-0.05591483,-0.0058268583,0.021164117,0.0032026703,-0.056151934,-0.0019852913,-0.026835704,-0.03663478,-0.04370284,0.0005819241,0.1017589,0.12189859,-0.075641096,0.09097761,0.004502044,-0.017356984,0.07477681,0.0348449,0.022771481,0.11904164,0.027621143,0.0016924575,-0.0035908248,-0.069789395,-0.07675891,0.087660335,0.024005266,-0.024926981,-0.022968898,-0.021342061,0.048120487,0.021519404,-0.009177983,-0.031627998,0.003414114,-0.0015568191,0.08042795,0.0018797345,-0.057837944,-0.013232905,0.03415796,-0.115410686,0.111388825,-0.010187379,0.020052899,-0.03631296,-0.02297167,0.07628063,0.042974032,0.08344547,0.086654104,-0.039245844,-0.044105005,-0.05106833,-0.018206378,-0.045560446,-0.009682612,0.0014175893,0.05850733,-0.025033213,-0.025462372,-0.07974303,-1.8819508e-33,0.012945896,-0.027602755,-0.009547683,-0.033968084,0.10799175,0.00036237863,-0.048704952,0.018060198,-0.075707294,0.03016058,-0.059936598,-0.0036055609,0.029785814,-0.0030984126,-0.02724049,-0.048636384,0.021936662,0.007677812,0.079709426,-0.0855582,-0.008531896,0.057752818,0.039893135,-0.04343785,0.029352456,0.004872545,-0.08365822,0.004688908,0.012319795,-0.011418204,-0.030802988,-0.050298147,0.0008141511,-0.035257768,0.024695827,-0.057400122,0.030714083,-0.07212155,-0.0113894595,0.04011934,0.058441937,-0.004970066,-0.018861651,0.03642212,0.0231502,-0.07456237,-0.1234277,0.122990504,-0.025180422,-0.00052742066,0.05538279,-0.057806786,0.15462594,-0.0064658606,-0.057379317,-0.011704278,-0.09619526,-0.0014847543,-0.00094291166,0.025085224,-0.024615435,0.0135752745,-0.06979161,0.02819333,0.005046465,0.0015296652,-0.0004728853,-0.020002332,0.041135024,0.1262296,-0.07914659,0.019810993,0.0359114,-0.076660715,0.0662172,-0.039819334,-0.06010543,-0.06444736,0.041543618,0.07516945,-0.039641753,-0.01794075,-0.003095921,0.035446312,-0.07357569,-0.09277087,-0.061690412,-0.016058113,0.06751117,-0.031222232,0.02650362,0.012304224,-0.07679982,-0.009630811,0.063057445,8.4638934e-35,0.017436298,-0.057257853,0.008036895,-0.021507485,-0.030956332,-0.010579711,0.010255776,-0.057506263,0.035194788,-0.028654376,0.06724246,-0.035244387,0.05372951,-0.0728317,0.038606457,0.041908793,-0.08004849,0.1221995,0.034071267,0.033399448,-0.10631243,0.010629054,0.011073305,0.02597471,0.02035304,0.023492659,-0.061882608,-0.016547138,0.02688495,0.03181324,-0.017501129,0.06004276,-0.023645794,-0.046648882,-0.06739443,0.0022819003,0.042617217,-0.031645067,0.06509181,0.07301523,0.10512162,0.09519906,0.028053856,0.11314396,0.06043113,0.10340265,-0.011961269,-0.010006631,-0.107331686,0.011432395,0.067207016,0.020229809,-0.013612161,0.02839969,0.026897443,0.07814831,0.008885721,-0.074629225,0.0044736005,0.029251693,-0.03898891,-0.0657295,-0.027761273,-0.003616518,-0.024280874,-0.0011618354,-0.01997113,0.12060344,0.07013625,-0.021371115,0.08219739,0.06819879,0.013215625,-0.0076728216,-0.0100329835,0.005597709,-0.024838965,0.013926768,0.026599951,0.05517138,-0.051262792,0.049158506,0.049891654,-0.08461294,-0.005242833,0.008941552,0.006290025,0.14720264,0.034286093,0.013684639,-0.06940676,-0.11322257,-0.0056286925,0.05843388,0.023560628,-2.324875e-08,-0.026789995,-0.005503826,0.05960013,-0.040105913,-0.04086605,0.11711612,0.042898234,0.004685722,-0.03309107,0.018779913,-0.025900327,0.050984178,-0.022577563,-0.014431242,-0.011538589,0.09719043,0.00672337,-0.061927218,0.0077742934,-0.006166092,-0.02777838,0.04873538,-0.03195172,0.016563581,-0.043585144,-0.045584112,-0.016209632,0.07396439,-0.14657257,0.01640547,-0.033833712,-0.00050375034,-0.017671892,-0.0066721616,-0.042375136,-0.0015885697,0.053240232,-0.05317966,-0.001881816,0.012485938,-0.032096177,-0.0069760582,-0.06685611,-0.06366021,0.011074146,-0.0006898321,0.040040746,0.051920567,0.04082782,-0.044277824,-0.028691769,0.011869764,-0.00524244,-0.0828505,-0.024290655,-0.020475794,-0.033810895,-0.018478036,-0.052142985,-0.050338265,0.045043096,-0.007099119,0.1250677,-0.07601361 +1.14.17.3,"A copper protein. The enzyme binds two copper ions with distinct roles during catalysis. Peptidylglycines with a neutral amino acid residue in the penultimate position are the best substrates for the enzyme. The product is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide, a reaction catalysed by EC 4.3.2.5 peptidylamidoglycolate lyase. In mammals, the two activities are part of a bifunctional protein. Involved in the final step of biosynthesis of alpha-melanotropin and related biologically active peptides.",384,1.0,-0.067632966,-0.08536454,-0.06263509,-0.0018224175,0.0630211,0.09786974,0.004351887,0.050384987,0.027528105,-0.016797867,0.03981275,-0.03456296,-0.08737559,-0.014004217,-0.06395215,0.026096545,-0.048199195,0.009170154,-0.03312764,-0.0065814755,0.037428576,-0.055084582,-0.044471078,0.00973547,-0.04770999,0.051987913,0.061510187,-0.077092454,-0.0055662203,-0.057125993,-0.00024720826,-0.07771941,0.006236253,0.014389288,0.020787388,0.023510376,-0.068391785,-0.07579035,0.017004792,-0.013512303,0.10007657,0.052759126,0.044771545,-0.047390718,0.034059353,-0.048266135,0.068744145,0.053846013,0.054124266,0.010073168,-0.027410058,-0.030054303,-0.0015806525,-0.0072590746,0.0030270242,0.031046607,-0.04140252,-0.09464336,0.01718797,-0.0012795936,0.031277854,0.010234725,0.0010900256,-0.001291072,0.018941058,-0.09605326,-0.049837895,-0.03662109,0.05796598,-0.028624907,-0.03540662,-0.07248071,-0.049522296,0.0022170597,-0.0038041912,0.07616825,0.09073522,-0.038873065,0.0068442943,-0.0203828,0.02476251,0.051329337,0.060153335,0.024092061,0.076554224,0.052345406,0.022120634,0.011324481,-0.029394897,-0.0814709,0.0913732,0.020560248,0.042912044,-0.024789859,-0.01928461,0.021599676,0.015691744,-0.046048697,-0.03906257,0.030414805,0.0066241706,0.10249761,-0.012864498,-0.0790911,-0.021069024,0.04362071,-0.045165733,0.119985834,0.020789508,0.00022447735,0.042291105,-0.041870654,0.03523904,0.022202346,0.022672491,0.046485897,0.02477109,-0.039236337,-0.033471223,-0.025608044,0.022344274,-0.01872019,0.032741033,0.026617121,-0.06185136,0.013291647,-0.046747815,3.3769356e-33,0.084349796,-0.021358637,-0.016253838,-0.010024598,0.072973266,0.026400542,-0.09051557,-0.027761403,0.03948378,-0.0028223076,-0.055659343,-0.015366859,0.007800159,0.013444708,-0.07225659,-0.055340342,-0.025502149,0.036844905,0.07931014,-0.014645484,-0.015854476,0.048914853,0.011216014,-0.027070148,0.06750155,0.0045890743,-0.058724787,-0.03539807,0.029445104,-0.0094054835,-0.026057532,-0.003586485,-0.07241983,0.025514422,0.04162891,-0.0770751,0.04840151,-0.082341604,0.07571122,0.084354624,-0.029304387,-0.011236333,-0.0034247038,0.0006389066,0.04541163,-0.04037854,-0.051114224,0.11674227,-0.014652054,-0.010152816,0.048671566,-0.055949505,0.13639735,0.012423973,-0.04793845,-0.05405615,-0.09209654,-0.046243764,0.061940905,0.090301484,0.004866689,0.03676345,-0.07282784,-0.026329603,0.010762151,-0.015370609,-0.043282278,0.0029544241,0.030002858,0.07214287,-0.03551468,-0.025061524,0.120034486,-0.0054810178,0.033325616,-0.096593484,-0.085533775,0.03219938,0.019849077,0.09866992,-0.016908785,0.057473615,-0.013775245,0.014294009,-0.0057140808,-0.019791542,-0.04946209,-0.062023707,0.051597513,-0.012248486,-0.042004194,0.04501164,-0.06420049,0.052428223,-0.028125105,-3.899064e-33,0.0794413,-0.1242374,-0.025898041,0.009604884,-0.051132746,-0.039285205,-0.013689454,-0.003485309,0.062126085,-0.04552207,0.07632285,-0.025726449,0.034708735,-0.041560695,0.068516135,0.05018396,-0.10417127,0.14699978,-0.04652518,0.0010907239,-0.07243361,-0.008065056,-0.028399067,0.035669815,0.088164076,0.004811458,-0.047138322,0.039460745,0.0647634,0.019214166,-0.026734237,0.056849293,-0.07780817,-0.03558389,-0.061327472,0.08886342,-0.021474414,0.03830148,0.027914854,0.074096374,0.08262333,0.07928263,0.0088192085,0.06280395,0.07599796,0.059067752,-0.042625353,0.040383793,-0.08010404,-0.0073658996,0.03720666,-0.057534553,0.030123385,0.040933985,-0.012664596,0.065276496,0.017589023,-0.021049814,-0.024575047,0.05663728,-0.03449657,-0.07268025,-0.0033839713,0.019386305,0.018639404,0.008325924,-0.0345051,0.09529779,0.06205398,-0.011323548,0.072824016,0.0050404505,0.07668673,0.02418873,0.029973997,0.05905761,-0.04451466,-0.06591185,0.04455753,-0.024602123,-0.03502545,0.045289498,0.033094097,-0.059140828,-0.039196685,0.0056515317,0.023320151,0.11032133,-0.0057413415,0.017793294,-0.03858732,-0.102790676,0.007768413,0.11591165,0.051630277,-3.8570818e-08,0.0349294,0.03903718,0.040540904,-0.06953095,-0.05385437,0.095402114,0.044514954,-0.022436433,-0.0014425468,-0.03522716,-0.013204684,0.040546454,-0.070792794,-0.042796664,-0.014848016,0.13137065,-0.015329383,0.0049272906,-0.010179601,0.023812532,-0.042573765,0.022290938,-0.063584544,0.03152596,-0.10687709,-0.06437666,0.019490542,0.07520887,-0.12538648,0.03296355,-0.022625897,0.0253504,-0.031716846,0.0070306687,-0.023375219,-0.027829595,-0.014662059,-0.07219853,0.02077631,-0.029224461,-0.05936351,-0.04386323,-0.06483093,-0.058136705,-0.028280808,-0.04883937,0.00824894,0.033978984,-0.01299525,0.007106462,-0.019112123,-0.011350468,-0.00057873456,-0.07796751,-0.031834807,-0.056816064,-0.048486456,-0.0450251,-0.044912428,-0.03421538,-0.023388939,0.024294222,0.1670735,-0.05636402 +1.14.17.4,"A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethene has signalling functions such as stimulation of fruit-ripening.",384,1.0,-0.034489352,-0.025817417,-0.01916004,0.07892834,0.13271819,0.038583368,-0.016272398,0.023568975,0.04011894,0.0031977717,0.031794377,-0.14595628,-0.09609223,-0.016771318,0.036197755,0.0055118464,-0.02371367,-0.012653562,-0.066506565,-0.09017175,0.06602555,0.016319683,-0.004965384,-0.024576126,-0.05577885,-0.050334837,0.035162743,-0.047090106,-0.030404927,-0.056977008,-0.033463597,-0.022249868,0.038299825,0.019236304,-0.064812645,0.031115768,0.047642853,-0.12774491,-0.004401716,-0.023557281,0.02240703,-0.0014076406,-0.025217714,-0.074506536,-0.043499812,-0.029883297,0.042590924,-0.038130596,-0.03428087,-0.020215336,-0.023650246,-0.09165699,-0.056453083,-0.032517396,-0.011800775,0.025988445,0.08711986,-0.0077640824,-0.037407078,-0.013642247,0.10308495,-0.10935304,-0.020199677,0.05887276,-0.006357211,-0.046500426,0.04546259,-0.032178883,-0.03737652,-0.03765644,0.008983272,-0.06191964,-0.102675006,0.03150298,0.013375667,0.028797051,0.0014879245,-0.029491741,0.040140916,0.0035233884,-0.024298359,0.04977506,0.048476793,0.052131917,0.038403496,0.07249844,0.033448003,0.0015273871,-0.03481299,0.070325956,0.01016693,0.0006328938,-0.08582702,0.009321676,-0.016316446,0.037459295,0.05625086,-0.026105747,-0.06970203,-0.013191892,-0.037281323,0.12858489,-0.051100772,-0.028415313,-0.07893228,0.025512472,-0.007328498,-0.007152041,0.0032770569,0.06985819,0.0025798883,-0.04984779,0.042423703,0.0052417284,-0.03166977,0.0851569,0.032164466,-0.042457532,0.024878146,0.047380485,0.077253565,0.047026012,-0.013756106,0.1328024,-0.050179977,0.0382109,-0.063617244,-1.2920137e-33,0.008452142,0.049226917,0.0045869206,-0.0077548474,-0.009905442,0.0018814334,-0.09134061,0.028334312,0.005708851,-0.039030593,-0.109928526,-0.020227032,0.103284895,-0.017943501,0.04905098,-0.036023993,0.056886166,-0.048769996,0.06928737,0.0018357651,0.03763222,-0.03932509,-0.033544704,0.023825735,-0.021803139,0.030269187,0.0071369964,-0.009158598,0.021665636,-0.04586747,0.024597596,-0.10009708,-0.015154996,0.02186632,0.09007297,-0.01985472,0.01026676,-0.012181647,-0.044809915,0.019993678,0.057368916,0.029873861,0.018198673,-0.029472455,0.036240727,-0.124912485,-0.06595366,0.08502717,0.0061154603,0.071520425,0.014557167,0.03818482,0.119736984,0.016065685,-0.061883878,0.039747983,-0.01843197,-0.008217576,-0.0405096,-0.011001986,0.04078717,-0.001623042,0.02054951,0.07424593,0.004925833,0.0904976,-0.11323866,-0.031520475,0.0058576926,0.13872834,-0.03990797,-0.0037456602,0.046827152,-0.015478474,0.06803405,-0.08526434,-0.06332857,-0.027125975,0.02531459,0.046072397,-0.018723624,-0.08560531,0.007062612,-0.03597238,-0.065549605,-0.048654485,-0.049639802,0.060485043,0.042570185,-0.010675444,0.1081837,0.028893143,-0.04098869,-0.017140364,0.015147578,-5.861069e-34,0.056810126,-0.028294772,-0.02637474,-0.06853755,-0.026791885,0.061484743,-0.069280416,-0.12731668,-0.0098392805,-0.031405773,0.068178825,-0.044291437,0.07962043,-0.053077668,0.040234964,0.07047889,-0.053772695,0.07955377,0.07265638,0.010801922,-0.03503935,0.049253963,-0.021486143,0.013611064,0.019322027,-0.017995128,-0.083230674,-0.001973768,0.0011039067,0.024693543,-0.007542881,-0.03034309,-0.025764823,-0.06589759,-0.026552297,0.04861832,-0.006028859,-0.024663998,0.048192404,0.09735265,-0.03295191,0.059733238,0.07390871,0.10715612,0.02240757,0.049580354,-0.0823084,0.026788326,-0.058357876,0.014651965,0.035251364,-0.0050717276,-0.09467226,-0.037345342,0.017109169,0.066106156,0.015702931,0.011910433,-0.034856666,-0.006350256,0.012338128,-0.04486606,0.011879094,0.031535793,-0.0074689994,0.013902538,-0.08204692,0.089686334,0.036546517,0.034492057,0.059868865,0.05046115,-0.018779144,-0.052825686,-0.07521478,-0.045575112,-0.022878276,-0.025015833,-0.05892454,-0.054673478,-0.02053641,0.05310626,0.013941839,-0.04097229,-0.014003084,-0.07517151,-0.053039175,0.020323634,-0.008762821,-0.019993844,-0.06942344,-0.048097752,0.0048356513,0.08915014,0.06227953,-2.812028e-08,-0.017814329,-0.08435764,0.029813794,-0.020315805,0.00036794314,0.001568824,0.07628109,-0.046773553,0.027490353,0.0002536019,-0.09199381,0.06467656,-0.005297574,0.06292138,0.09225119,0.041790694,0.053919602,0.07452517,-0.010273748,0.028224612,-0.046171326,0.01195169,-0.13511366,0.03346943,0.012997446,-0.034620993,0.04146161,0.07349405,0.018502,-0.014398422,0.018420067,0.030955968,0.04928813,-0.03000929,-0.08246573,0.06486129,0.016551405,-0.008048792,-0.08173218,0.006979413,-0.024606492,0.0324164,-0.06643918,-0.03135006,-0.01193673,-0.028137246,0.06404451,-0.013177648,0.042474028,0.015374868,0.038227744,-0.017151855,0.05455542,-0.009487797,-0.03179264,0.037771933,0.030838884,-0.03981379,0.06219353,0.009131686,0.033629294,0.05839864,0.1422793,-0.06848142 +1.14.18.1,"A type III copper protein found in a broad variety of bacteria, fungi, plants, insects, crustaceans, and mammals, which is involved in the synthesis of betalains and melanin. The enzyme, which is activated upon binding molecular oxygen, can catalyse both a monophenolase reaction cycle (reaction 1) or a diphenolase reaction cycle (reaction 2). During the monophenolase cycle, one of the bound oxygen atoms is transferred to a monophenol (such as L-tyrosine), generating an o-diphenol intermediate, which is subsequently oxidized to an o-quinone and released, along with a water molecule. The enzyme remains in an inactive deoxy state, and is restored to the active oxy state by the binding of a new oxygen molecule. During the diphenolase cycle the enzyme binds an external diphenol molecule (such as L-dopa) and oxidizes it to an o-quinone that is released along with a water molecule, leaving the enzyme in the intermediate met state. The enzyme then binds a second diphenol molecule and repeats the process, ending in a deoxy state [7]. The second reaction is identical to that catalysed by the related enzyme catechol oxidase (EC 1.10.3.1). However, the latter can not catalyse the hydroxylation or monooxygenation of monophenols.",384,0.99999994,-0.14172389,-0.08286653,0.007994227,0.035905633,0.10058244,-0.012372963,0.005455286,0.021218048,0.066173494,-0.026738027,0.050254095,-0.04287381,-0.12331177,0.006755067,-0.08846079,0.08935561,-0.09253526,0.0042209374,-0.030368404,-0.030645458,0.090900205,-0.00032505635,-0.014146158,0.00840236,0.0057683815,0.015325125,-0.01496543,0.0064512705,0.021848308,-0.05077789,-0.010096483,0.041799977,0.0139320465,-0.0030767438,-0.012857709,0.042741366,-0.0061812205,-0.088544704,-0.014009862,0.050750867,0.04570481,-4.7141795e-05,-0.0056508793,-0.0049156114,0.027266521,-0.05245604,0.028514113,0.030381741,0.035440758,-0.048450053,-0.013541898,-0.08719377,-0.027715515,0.078877024,0.015183115,0.04866961,-0.023627315,-0.027626857,-0.024352547,0.005826799,0.0001426498,-0.002902483,-0.04749557,0.020972922,0.057925366,0.011536067,-0.051634047,-0.06855334,0.02501651,-0.06126171,-0.07769664,-0.039407477,-0.025721814,-0.043447237,0.009925343,0.072124146,0.10922195,0.0027131275,0.043224256,-0.03302987,0.0047511845,0.025562532,0.009479328,0.043126807,0.056816164,-0.0013164178,-0.0035185192,0.029594595,0.031066503,-0.00932531,-0.019380981,0.013498226,-0.020880243,-0.060392562,-0.05181494,0.06040275,0.097245865,-0.010035795,-0.0015232806,0.08880471,0.020500358,0.06177593,-0.0030275926,-0.10919653,-0.08076225,0.016230509,-0.007912105,0.072353795,0.015825989,0.0012472955,0.050540872,-0.015620413,0.09971729,0.01964336,-0.024042316,0.03248991,-0.005814057,-0.021832712,0.013752303,-0.014340907,-0.013057588,-0.040722396,0.02307915,0.0062347227,-0.03492162,0.07235836,-0.051210858,1.6260619e-33,0.12088728,0.014338904,-0.0032517512,0.05217124,0.036685653,-0.031503484,-0.05898426,0.025514122,-0.035816062,-0.01905685,-0.06852746,-0.030873494,0.028013665,0.029102007,0.007835094,-0.06610235,-0.022669572,0.002531392,0.055474464,0.013179686,0.022708595,0.012023383,-0.0673692,0.004146868,0.053137172,0.060403462,-0.06310041,-0.016594004,-0.011742847,0.0021954062,0.0068375585,-0.049499866,-0.060893208,0.017560545,0.023208171,-0.039428215,0.008230287,-0.045167413,0.03037213,0.052636463,-0.010479989,0.033938203,-0.00032865422,-0.0033097642,0.07102426,-0.13723484,-0.025255626,0.117275916,0.036237884,0.039625116,0.053641826,-0.047087867,0.10071582,0.033171885,-0.03850859,0.02655169,-0.057869997,-0.032153554,0.08801054,0.03473072,0.050508186,0.047137238,-0.05065745,0.004797492,0.0094605265,0.101131134,-0.11196147,-0.012762288,0.008060996,0.07562595,-0.049110476,-0.013681878,0.0041957926,-0.00042212353,0.024809381,-0.020512784,-0.03715447,0.004973066,0.054980565,0.024481386,0.019500757,-0.055490732,0.020017996,-0.02046982,-0.06775394,-0.015023907,0.028921237,-0.052708942,0.021669194,-0.0019199057,0.008438822,-0.07509643,0.03660157,-0.07195839,0.04428187,-8.357416e-34,0.11457148,-0.12098051,-0.06699048,-0.106481925,-0.04177218,-0.037285764,-0.04984008,-0.032218754,0.008569209,-0.065904,0.047117878,0.0152768865,0.07601583,-0.027827175,-0.007937652,-0.03545722,-0.030286957,0.09112773,-0.010397197,0.015764417,-0.01062946,0.06392711,0.014994107,0.022902152,0.011272723,0.013166019,-0.05887751,0.06684952,0.022405222,0.06283469,-0.060741298,-0.007593616,0.026064483,0.027666979,0.023285955,0.080695584,-0.0014597527,-0.057068326,0.061479066,0.10262502,0.013445843,-0.050029237,0.032241512,0.07960365,0.062337432,0.13174124,-0.14387435,-0.019665828,-0.06354201,-0.020294968,0.028829735,0.02629654,-0.027325446,0.024967859,0.013535567,0.021013452,0.012891326,-0.07815533,-0.042174544,0.0021097085,-0.041761816,-0.11978985,-0.0059320927,0.044857927,0.009811516,0.029624933,-0.102338515,0.10178829,0.053281847,-0.04872387,0.023256037,0.021101546,0.050665252,-0.021393368,0.0038106507,-0.03754407,0.008586693,-0.013464791,0.053228375,-0.07338896,-0.09418763,0.025695283,-0.020877674,-0.036656186,-0.057530332,-0.06923678,-0.00711797,0.076585986,-0.026463069,-0.00612368,-0.067754954,-0.016122147,-0.038424294,0.14487138,0.1591935,-4.8582415e-08,0.014367887,-0.004688159,0.07082289,0.016247954,-0.003549383,0.05634702,0.08182118,-0.0060406467,0.032382406,-0.030909026,-0.032781173,0.11279581,0.016612321,-0.062969685,0.052465733,0.07165592,0.026304753,-0.041636027,-0.055694718,-0.026708081,0.01216822,0.00076540635,-0.0292287,0.06017785,-0.02621873,-0.097442865,0.009362126,0.067219526,-0.10338705,0.01666765,-0.014378864,0.06725704,-0.016843406,0.00835913,-0.02704146,0.024499094,-0.042970978,-5.477256e-05,0.0042389194,-0.008929862,-0.038039323,0.025592718,-0.14609809,-0.029121723,0.031995922,-0.0041414015,0.030308181,0.029687399,0.050408952,0.010137054,0.029876288,0.023248073,0.024773967,-0.009688455,-0.10979761,-0.002243563,2.1970061e-05,0.014764388,-0.024626648,-0.023254953,0.0049821977,0.023929985,0.17014493,-0.055842675 +1.14.18.2,This enzyme contains both a Rieske-type [2Fe-2S] cluster and a second iron site. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2). The enzyme can be activated by Fe2+ or Fe3+.,384,1.0,-0.00591832,-0.010437851,-0.11527224,0.06859142,0.1380042,0.0030199054,-0.055578865,0.0021604917,-0.036726158,-0.09315169,-0.05592612,-0.05189562,-0.015745392,-0.045998674,-0.02324337,0.01709386,-0.029610455,-0.016293025,0.017686818,-0.029111069,0.031902526,-0.05732696,0.057960384,-0.04524612,-0.034405973,0.014840962,0.11445347,0.0056055957,-0.059459187,-0.13008785,-0.00021541056,-0.009098893,-0.02400184,-0.049653765,-0.019168904,0.07312464,0.0039223465,-0.00059474277,-0.02895031,0.013539169,-0.051160485,-0.037070792,-0.049058497,-0.0042699473,-0.027639404,-0.07264084,-0.030960666,0.00312845,0.045675945,-0.041046973,-0.060679458,-0.046280343,-0.03230604,0.06503607,0.05790201,-0.013269067,-0.019768078,-0.03969245,-0.0077068377,0.013801294,0.093100846,-0.03112315,-0.015931968,0.0155984685,0.027899554,0.025625944,0.028373927,-0.09007336,0.012427179,-0.11308615,-0.031053783,-0.03287091,-0.012685963,-0.022934983,0.00056863006,0.04073962,0.037523147,0.069055185,0.08047809,-0.0034578596,-0.057147153,-0.04705842,0.10511183,0.09005745,0.04325519,0.03881787,-0.042474534,-0.04070291,-0.048729915,0.030311443,0.041277293,0.044908524,-0.02228006,-0.020825211,-0.09055532,0.01760855,-0.045434136,0.07164066,0.023927126,0.0040787687,-0.05367531,0.071559526,-0.021679698,-0.070615746,-0.057892654,0.005749773,-0.031091599,0.10772068,0.061054997,-0.052353144,0.020731186,0.055991314,0.013531373,0.0078102713,0.007932107,0.081625,0.1131917,-0.029043285,-0.0335944,0.018612089,0.09086676,0.05680144,-0.021468472,-0.019194461,-0.05482762,-0.0030997288,-0.15321164,2.3227691e-33,0.043603044,0.046898615,-0.0019424245,-0.009417763,-0.022072144,0.060603514,-0.098137334,0.009255941,-0.03386748,-0.0014008242,-0.036347736,-0.038506635,0.034589622,-0.044963937,0.019769076,-0.09432143,0.049177606,-0.040969964,0.067083284,-0.056195,0.03004741,0.10811633,-0.050113574,-0.018572493,0.026814293,0.110774495,-0.0021029457,-0.0072537777,0.00393111,0.021936541,0.0060255346,-0.068428,-0.119653046,-0.009336695,0.008383969,-0.055187255,0.009173638,0.025346577,-0.052913047,0.00153068,0.03992678,0.02635219,-0.011150546,-0.054700922,0.09482696,-0.13952349,-0.08924132,0.07865703,0.09975398,0.085493475,0.008514561,-0.029776653,0.088219844,0.013529284,-0.03985166,0.053453036,0.023820678,0.0048405416,0.03287421,0.08732307,0.07664024,0.053317588,0.002342199,0.063180625,0.03450011,0.019439561,-0.0064514526,-0.035922814,-0.022269735,0.103813685,-0.033525057,0.09302517,0.15259865,0.0021123444,-0.00948142,-0.07014012,-0.065659955,-0.024642693,0.050523337,0.017982353,-0.017110359,-0.06095887,0.0034624138,-0.011768645,-0.019044613,0.001666802,-0.040845834,-0.06271254,-0.02763613,0.0025135216,0.026593592,-0.035878886,-0.06583474,-0.033138048,0.0089067565,-3.3725906e-33,0.07395202,-0.048275355,0.02781833,-0.07553074,-0.050440475,0.06560915,0.08280903,-0.05754596,-0.03884563,0.061370406,0.113162026,-0.009846077,0.022873042,-0.05966246,-0.0026240891,0.013801918,-0.0016817538,0.060660042,0.056830283,-0.006292968,-0.019207796,0.07262434,0.067845576,0.0115269115,0.060626663,-0.0057583847,0.014326725,0.036103416,0.050707787,0.05553209,-0.02066211,0.009289668,-0.002052151,-0.05795509,-0.027508708,-0.0070849,-0.039312627,0.020936338,0.016544787,0.015637929,-0.0541188,0.0018700518,-0.08689211,0.09631386,0.021137847,0.057965722,-0.07184006,0.043600045,0.022684598,-0.05223823,-0.007171535,-0.023187432,-0.059599612,0.04567268,-0.053581443,0.0045454334,0.009647714,-0.0006654662,-0.033920318,0.033444695,0.0035004187,-0.042345762,0.04599959,0.013729856,0.10847722,0.049608376,-0.020634122,0.075324506,0.007844137,0.029574763,0.048413176,0.022763807,0.0775338,0.05515107,-0.0242635,-0.024334997,-0.002656816,0.008079271,-0.036888402,0.0072780796,0.045908917,0.019834409,-0.04140793,-0.06591703,0.008099707,-0.1043495,-0.005309464,0.06285922,0.046659965,-0.03750235,-0.038716327,0.0474504,-0.039966412,-0.0036934782,0.030285725,-3.2099177e-08,0.0020407166,-0.08905811,0.015486217,-0.04340664,0.06994727,-0.02588776,-0.08234023,-0.028081367,-0.029767867,0.010104588,-0.04910046,0.11906204,0.0035637543,-0.030415079,0.059109572,0.03177131,0.066213764,0.03106808,0.023328241,0.021637196,-0.02516357,-0.05024017,-0.053884484,0.0087722745,0.04417509,-0.1217603,-0.040797006,-0.050085176,0.044814397,-0.036350936,-0.007880022,-0.008912509,0.05489097,0.014896273,-0.050503485,0.032582372,-0.071221374,-0.0049925353,-0.07405117,0.027674556,-0.012719797,-0.04439757,-0.02114788,0.011156898,-0.036549084,-0.035384852,-0.008847021,-0.0024071392,0.02619031,-0.029840477,-0.0055204676,-0.041797757,0.0386512,-0.041998494,-0.10637668,0.09540396,-0.017920302,-0.024645131,0.07760245,-0.042976573,0.036211487,0.030835934,0.08850775,-0.051191315 +1.14.19.1,"An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).",384,1.0,-0.010152922,-0.022216616,-0.100773744,0.06306056,0.063364364,0.037476886,-0.004742955,0.017703941,-0.018036665,-0.054662894,-0.050887674,0.0065371916,-0.042650834,0.008611114,-0.021584706,-0.02176048,-0.031794567,-0.03601329,0.0029024596,-0.042944957,-0.016426591,-0.036668006,-0.029716715,-0.059026245,0.013741987,-0.022120824,0.10998787,-0.021338146,-0.097266406,-0.046827167,-0.044466794,-0.06566025,0.030502336,-0.0754998,0.012898107,0.018487556,-0.030481707,-0.029923964,-0.051061515,-0.026667317,-0.020781143,0.03346143,-0.044163737,0.0051392447,-0.054653775,-0.022309925,0.04911632,-0.030064391,0.04265307,0.040924985,-0.04411061,-0.012579996,-0.049766835,0.06740038,0.0026739887,-0.029923277,-0.030998474,-0.07659234,-0.052326255,-0.024308998,-0.021392602,-0.03342696,-0.018545939,-0.021261321,0.09928479,0.019791495,0.018325707,-0.02730477,-0.06616453,-0.08723407,-0.03353078,-0.06947681,-0.018455544,0.01848251,-0.056162793,-0.012972016,-0.021207502,-0.0117764715,0.0977093,0.05738112,-0.053276032,0.004196833,0.012901126,0.100588955,0.01195004,0.054988377,-0.06975352,0.0114614805,-0.07193396,0.027113166,0.020179396,0.010333723,-0.008418887,-0.024985477,-0.033946455,0.014865543,0.019892814,0.08553557,0.019871471,0.008342994,0.013661219,0.09218863,0.00059088826,-0.07843488,-0.018983398,0.028937409,-0.025376907,0.15286611,0.047761016,-0.06555903,-0.024800783,-0.0068672015,0.012948585,-0.0040002638,0.040561363,0.08480776,0.1092619,-0.038264774,-0.048756666,0.08846992,0.085028574,0.09223946,0.08462947,0.064646736,0.008857191,0.006905573,-0.10635721,2.1230941e-33,0.06529417,0.029185373,0.009994301,0.025904277,-0.03074523,0.057491373,-0.025985945,0.05252503,0.008319662,0.02903056,-0.07458111,-0.032060944,0.059400257,-0.049103446,-0.0035421348,-0.029245688,0.013256527,-0.040889643,0.10832263,-0.008356962,-0.0025250725,0.06818209,0.016612709,0.011901787,0.04034952,0.07399546,-0.08314281,0.046903107,-0.06720391,0.01584829,-0.030177426,-0.018965783,-0.08672262,-0.019361354,0.034680646,-0.09917678,0.028721118,-0.0036844874,-0.07682834,0.0026051297,0.046937827,-0.0738676,-0.061329763,-0.022892697,0.10000893,-0.095195346,-0.1437215,0.049229458,0.026965138,0.0722896,0.06497782,-0.038045637,0.14581591,-0.060157295,-0.0808444,-0.007030571,-0.01929024,0.042659525,-0.05748359,0.112345465,0.06722309,0.04422587,-0.037226774,0.1050874,0.027269095,0.002210615,-0.0733303,-0.04923713,-0.048558034,0.07300075,-0.060290545,0.060567252,0.0986197,-0.00017942365,0.020215765,-0.06331895,-0.0865397,0.021837436,-0.018623631,0.018269699,-0.030788971,-0.012316551,-0.04510942,-0.051752135,-0.03561596,0.032433406,0.04616819,-0.046549026,0.024978977,-0.05140031,0.04529281,-0.05209756,-0.085845806,-0.012737388,0.034188233,-4.491365e-33,0.051146336,-0.05888861,-0.00768494,-0.049042396,-0.06444914,0.031595834,0.053131297,-0.07008828,0.010827205,0.047267016,0.077112876,-0.028551755,0.0070089945,-0.027520677,0.053752594,-0.001150293,-0.027028913,0.013922449,0.094917916,-0.04198473,-0.0910768,0.048161544,0.050359994,-0.022246022,0.056133103,-0.019560317,-0.035845377,0.02323687,0.107684515,0.036881212,-0.049316093,0.028465025,0.031525828,-0.04947493,0.013185098,0.028654046,-0.056497067,-0.019033,0.043172974,0.007660672,0.0061669867,0.032485735,-0.021598795,0.08224557,0.042571343,-0.0063031265,-0.1018683,0.048563246,0.012475441,-0.038636003,0.016158547,-0.051757146,-0.04825916,0.023376385,-0.008223526,0.016422274,0.051042013,0.061536312,0.04159504,0.05593083,-0.06535709,-0.024655432,0.04706815,0.08335817,0.05365126,0.018660292,-0.021257117,0.054714397,0.0327678,0.03812314,0.057469208,0.014392192,0.06099781,0.108606525,0.034741826,-0.030664627,0.026104106,0.061985824,-0.032593403,-0.041329052,-0.0074957656,0.022809783,-0.0175903,-0.05175107,-0.012125545,-0.085163295,-0.039467562,0.073442005,0.06684881,-0.03907378,-0.011759299,-0.01743457,-0.07061822,0.0019889115,-0.04838515,-4.230841e-08,0.008850924,-0.032275304,-0.0043905615,-0.007911468,0.028542858,0.014192059,0.0446446,-0.06604342,0.018486487,-0.004387494,0.021327373,0.12599888,-0.014160003,-0.044141356,0.03098387,0.043244448,-0.041911013,0.045354743,0.0468402,0.07041943,-0.000106612904,-0.040961254,-0.054732535,0.055165585,0.005919389,-0.12821668,-0.040617183,0.028252224,0.026284674,0.004380209,-0.02902342,0.004184813,0.05917717,-0.0019275426,-0.071028255,-0.022669412,-0.045458727,-0.038586322,-0.05205097,0.06074257,-0.029564766,-0.09260052,-0.05622344,-0.080201164,-0.0053469804,-0.0427629,0.0006580869,0.015589015,0.027943965,-0.011395003,-0.034787774,-0.0055723423,0.0026336533,-0.055342026,-0.047811113,0.01571931,0.039775647,-0.09183035,0.038750205,-0.074412435,0.020003393,0.10743623,0.08822297,-0.0537505 +1.14.19.2,"The enzyme is found in the lumen of plastids, where de novo biosynthesis of fatty acids occurs, and acts on freshly synthesized saturated fatty acids that are still linked to acyl-carrier protein. The enzyme determines the position of the double bond by its distance from the carboxylic acid end of the fatty acid. It also acts on palmitoyl-[acyl-carrier-protein] [4,5].",384,1.0,-0.08301083,-0.08139055,-0.059527315,0.031767573,0.019265989,0.04458143,-0.09361805,0.051107362,0.03842475,-0.0443591,0.09405945,8.121546e-05,-0.067808166,-0.015911141,0.010069964,0.039167665,-0.057348073,-0.0015031642,-0.01945103,-0.084036626,0.1653632,-0.04077578,-0.0049699787,-0.063860446,-0.009108619,-0.03797064,0.055228256,-0.03732398,0.008747779,-0.052799404,0.029897343,-0.053343963,0.031887263,-0.024675488,0.034994338,0.023902224,-0.013882643,-0.057288773,0.09181839,-0.002012786,0.0535043,-0.07036088,-0.02472732,-0.003196539,0.033190135,-0.06372853,0.0075530433,0.082382984,-0.03066651,-0.02007987,-0.0054446156,-0.0708748,-0.031887755,0.008235562,-0.019077454,0.06764989,-0.024222014,-0.0101205865,-0.021342427,0.01945885,0.062744334,0.04178373,-0.014186469,0.01731242,-0.0122990925,-0.09071498,0.06149015,-0.05946041,0.013872312,-0.03650995,-0.022036275,-0.05611464,-0.00070701184,0.011020215,0.047866765,0.018632563,-0.01803584,-0.016438862,0.018217262,-0.027362362,0.053893622,0.00020737978,0.011262041,0.06611586,0.06075466,-0.03180266,0.032483585,-0.0046965373,-0.03338919,0.016308427,0.060514987,-0.06556864,-0.09702032,0.0063703526,-0.09341212,0.08227519,0.016545936,-0.0047897575,-0.016422138,-0.032572888,0.0048427857,-0.0068133934,-0.013277313,-0.06987145,-0.07815233,0.016219122,-0.084333256,0.05498156,-0.04651027,0.0014520824,0.011536229,0.036053766,0.03437093,0.03637208,-0.036096986,0.055941254,-0.039415244,-0.05753459,-0.0073741847,-0.0367393,-0.04690453,-0.032284245,0.032739818,0.08936585,-0.0026978538,0.016088227,-0.11825081,-7.738238e-34,0.053009626,-0.03604162,-0.011970051,-0.02874612,-0.015587655,-0.080718435,-0.03417677,0.04687465,-0.1263443,-0.010256228,-0.0022773691,-0.04359538,0.039897326,0.06549891,-0.003540734,-0.05198493,0.05124242,0.03178026,0.017460903,-0.003210742,-0.05292706,0.09304914,0.040755365,-0.05423219,0.045749594,0.07780298,-0.043002672,-0.082491815,0.05900721,0.0340437,-0.046864424,-0.05264493,-0.018022459,0.06888381,0.08543176,0.046977695,-0.02884515,-0.04813775,-0.08010926,0.036600277,0.08710396,0.018292703,-0.0053339745,0.008377165,0.045989297,0.023271425,-0.059151754,0.036239866,0.05679775,0.025190465,0.02231998,0.006776881,0.10547197,0.031032229,-0.05380202,0.028806102,-0.09726599,-0.052814897,-0.003499867,-0.046871167,0.037613366,0.054374054,-0.038918775,0.0076388204,-0.016084721,0.040875793,-0.12274066,-0.04674763,0.0033743558,0.1560846,0.014203807,-0.021684252,0.023533858,0.059529345,0.061060585,-0.023212647,-0.015754795,0.09625481,-0.008581429,-0.0060239593,0.039643224,0.025446247,0.023135722,-0.063276224,-0.08045207,-0.01896023,-0.052463997,-0.054919098,0.048778035,0.009373579,0.00357317,-0.023097591,-0.010523227,0.0576285,0.004038546,-1.5496154e-33,0.07930886,-0.11356129,0.09359397,-0.058251742,-0.026338968,0.044378437,-0.03185203,-0.014218315,0.019566588,0.022121273,0.021408094,-0.019645771,-0.025730895,-0.044166442,0.08275085,0.10050486,-0.03142236,0.010715183,-0.010245718,-0.028813401,-0.021440718,0.010038898,0.084488414,0.07575879,0.022721553,-0.022517396,-0.009647625,0.056886584,0.0008582097,-0.016405849,-0.043244496,-0.044794336,-0.05831887,-0.008082246,-0.072836086,0.055201594,-0.06588543,0.039658066,0.009552787,0.09933061,-0.0072589447,0.013804173,0.014914736,0.02729701,0.08234877,0.008254576,-0.047249757,0.0031435178,-0.0067715533,-0.15734255,0.07870699,0.008100439,0.040642146,-0.0025216718,0.072821975,0.121028155,-0.007107671,0.038296945,0.00044777084,-0.06076116,-0.041451924,-0.06588187,-0.01449648,-0.015829261,0.040503096,0.044493165,0.008761174,0.010726997,-0.05301908,-0.011311576,0.05456221,0.040959932,-0.054260552,0.07752657,-0.01364283,-0.0138727985,-0.07594321,-0.10353381,-0.061167676,0.011868165,-0.02148971,-0.00946936,0.0027467862,-0.06178156,-0.036706217,-0.03854896,0.07099944,0.054796614,0.0015960357,0.02157495,-0.026543325,0.0062204082,-0.06154733,0.04895252,0.056485403,-3.7566025e-08,0.03704242,-0.06631627,0.041015916,-0.03093895,-0.04285479,0.021008594,0.048585128,-0.023425642,0.034635004,-0.07692753,-0.11559532,0.06485037,0.02825565,0.05837093,0.022685181,0.026801594,-0.05162125,-0.009452369,-0.028853476,0.0023792174,-0.07169892,0.0066177784,-0.025612803,0.06550924,-0.01257429,-0.007168448,0.012492599,0.028728828,-0.023679512,0.055632327,0.020945285,0.01467433,0.047674865,0.0024212562,0.022198863,0.023444943,0.0052555716,-0.046813052,-0.07846611,0.11820521,0.061657242,-0.030251572,0.03693553,0.027313963,0.073895395,-0.009481465,0.0007234672,0.05848713,-0.005438829,0.046397846,0.015986985,0.03544788,-0.082711995,-0.07092794,-0.09528101,-0.10822189,-0.035241403,-0.08499079,0.011012874,-0.018184822,0.024655908,0.024824008,0.19639958,0.024617871 +1.14.19.3,"An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA [4], and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate [3]. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase.",384,0.99999994,-0.07109172,-0.04548597,-0.13074687,0.057987176,0.043848198,-0.0034653223,-0.05561426,0.09869348,0.018336214,-0.033080265,0.008525769,-0.040449597,-0.082005635,0.03036991,0.015563603,-0.04774113,-0.028353672,0.011374252,-0.013223597,-0.0019046657,0.07515412,0.04984512,-0.00033989892,-0.04015954,-0.016738703,-0.034518894,0.062048037,-0.044088393,-0.022056129,-0.050966814,0.03745251,-0.038588084,0.0056543024,-0.039521836,0.024615645,0.05438529,0.027432613,-0.10229371,-0.024576584,-0.021812988,0.047477264,-0.077183366,-0.050439343,-0.02646191,0.0067247944,-0.12245459,-0.028575748,0.08033812,0.04579871,0.04689019,-0.05773193,-0.025051525,-0.05477811,0.05027613,-0.028990699,0.00915272,0.0030632562,-0.01266417,-0.062017366,0.025729567,0.07428963,-0.024942886,-0.062759474,-0.0031955647,0.012583158,-0.027200833,0.04666476,-0.053999487,0.030572582,-0.022985816,-0.07095109,-0.02001144,-0.049042877,0.0110216355,-0.015130502,0.082976274,-0.009057928,-0.044048052,0.05587856,-0.030746523,0.0092781875,0.058802713,0.088399634,0.12909064,0.05938202,0.032569703,-0.021698821,-0.0021175907,-0.008107795,0.09075153,0.016819522,0.0203908,-0.0431886,0.014173036,-0.12723294,0.04365884,0.042467646,0.0333563,0.017849928,0.030804707,0.013071284,0.056752164,-0.010312062,-0.089819714,-0.04550331,0.041288953,-0.08525996,0.05430384,0.03788205,-0.0026162243,0.013900768,0.02824627,0.026091129,0.014984809,0.038513258,0.065455966,0.027094683,-0.058933396,0.025301019,0.030602176,0.021190468,0.008322212,0.034891125,0.0280073,0.030133992,0.011259749,-0.091469295,5.4028795e-36,0.049188796,0.05556082,0.09362134,0.056904707,-0.008164987,0.018934805,-0.10820866,0.026963064,-0.11834727,0.035905298,-0.05952117,-0.040113945,0.091017485,0.039979283,-0.0060436875,-0.05032447,0.00327133,0.03371862,0.09223272,0.022607252,0.026784632,0.1167064,-0.012189799,-0.05559718,-0.02717538,0.10399609,-0.090492874,0.052760527,-0.014087531,0.03827211,-0.09441825,-0.08162476,-0.06763747,0.016002938,0.07101513,-0.023519998,-0.009017966,-0.059314243,-0.06329021,0.046787955,0.123517804,-0.021012016,-0.019813143,-0.045909192,0.082532324,-0.08385087,-0.04136324,0.048049226,-0.024120787,0.03988709,0.02223113,0.013927128,0.07862087,0.012437924,-0.1464046,0.052494667,-0.043038692,0.014064527,0.059202794,0.060589287,0.03965708,0.056181017,-0.039158348,0.07211014,0.013474205,-0.024936406,-0.062655315,-0.015674695,-0.063389234,0.13043614,-0.011649428,0.019771965,0.07667008,0.006735557,0.07518618,-0.045308776,-0.035608202,0.062413637,0.049832232,0.042074684,-0.008245523,-0.0030784204,0.0014164739,-0.08687808,-0.09618303,0.012808409,-0.05476562,-0.036588125,0.010379939,-0.027115688,0.050013393,-0.11286633,-0.037960622,-0.023634147,0.012699322,-2.0682963e-33,0.07660928,-0.084541425,0.022336448,-0.08435608,-0.046408545,0.005562495,0.041082356,-0.041332193,0.0038203702,-0.015847107,0.17992578,-0.042961754,0.040227197,-0.054191448,0.012970291,0.052650847,-0.02640287,0.023992758,0.023832003,-0.012290281,-0.00096521433,0.050249174,0.027297435,0.06763004,0.039622992,-0.026203865,-0.012394357,-0.014940135,0.014446327,0.07552677,0.013792509,0.0018026803,-0.028367884,-0.07401879,-0.038949534,-0.014523059,-0.09552782,-0.010989796,0.09286207,0.028479332,-0.018562652,0.0019500068,0.032319047,0.04986994,0.06398191,0.040783938,-0.10617719,-0.027610775,-0.024574399,-0.006111112,0.031056408,0.012670082,-0.040420283,0.0466089,-0.0061434475,0.03702584,0.06315624,0.0074406466,0.021388128,0.05477049,-0.017847039,0.0016751019,0.0072056046,-0.0019687451,0.09370796,0.03408385,-0.07731245,0.0416035,-0.017417569,-0.0020470845,0.05095713,0.06672873,-0.010244679,0.00016447615,-0.024098827,-0.036577486,-0.030466527,-0.040131204,-0.06514817,0.0034104665,-0.062435374,-0.052955568,-0.014204049,-0.049473256,-0.025052367,-0.064941116,-0.01770944,0.07584797,-0.011535763,0.042032395,-0.07370032,-0.040115666,-0.07716893,0.053616464,0.05246022,-5.6078605e-08,-0.03227159,-0.07486548,-0.046361435,-0.037209485,-0.03197868,-0.024332758,-0.02892993,-0.07815927,0.03508428,-0.06424779,-0.00048682414,0.080381796,0.007814502,0.041071106,-0.0002881351,0.016190544,0.032420073,-0.0012286536,-0.0111274365,-0.0580699,-0.033101514,-0.019877277,0.0017451631,0.020376077,0.060227964,-0.08350043,-0.0056318208,0.044220753,0.07505413,0.003093659,-0.05201677,0.007579573,-0.038875137,0.05273718,-0.008759393,0.0118188625,-0.014780204,-0.036008965,-0.084376715,0.096475184,0.034431323,-0.038219847,-0.085733086,0.023362847,0.0337996,0.0016056546,0.013512545,0.05340882,0.010305059,-0.022177987,-0.007414128,0.019243384,6.9048256e-05,-0.03221072,-0.060440168,0.050894916,-0.010018106,-0.05451728,0.025206415,-0.035054788,-0.001907941,-0.0016644229,0.15646546,-0.047505133 +1.14.20.1,"Forms part of the penicillin biosynthesis pathway (for pathway, click here).",384,1.0,-0.048827186,-0.029001044,-0.04771533,-0.0447425,0.040290203,0.014467969,-0.04228704,0.05667634,0.09430848,0.017297916,0.028826479,-0.016729323,0.024900507,0.052507203,0.0016907611,0.019277016,-0.16159223,0.03515545,-0.01440435,-0.04104534,0.089725874,0.10994927,0.014260399,-0.014456696,0.054216117,0.0064999093,0.074088685,0.021694165,0.078251116,-0.00214373,0.036875986,0.005804696,0.007731518,-0.063296475,0.06706075,0.044889987,-0.07035837,-0.026556876,0.15776171,0.021656599,0.058139585,-0.01932276,-0.021192167,-0.0089716315,0.0025015408,0.044359036,0.025089782,0.016220031,0.0019452298,0.027908912,-0.01773308,-0.06669998,-0.040641382,0.06649538,0.07347699,0.034417797,-0.056923274,-0.108137466,0.020931864,-0.03647879,0.028959345,-0.01891225,0.003702267,0.032488786,-0.07420066,-0.016184721,-0.0059723486,-0.03563125,0.052634012,-0.057609215,-0.039054822,-0.049517754,-0.0041372087,0.025112597,0.005856087,-0.028645433,0.026245145,0.035576556,-0.038853597,-0.049106207,0.06309508,0.017104259,0.0013503255,0.10204559,0.06794478,-0.041907627,0.065850295,-0.0016937433,0.06568213,0.028160335,-0.0018885669,0.014058249,0.030309025,-0.048787463,-0.0605159,-0.028434448,-0.0070557455,0.03021327,0.0198555,-0.003005816,-0.03346375,0.034262445,-0.026084196,-0.014365748,-0.03995492,-0.045557454,0.020483498,0.10269345,-0.061165795,-0.034346804,0.00027925303,-0.04462465,0.024054613,-0.02540227,-0.017971393,0.028521864,-0.023607736,-0.025708616,0.024700249,0.10355358,-0.033697363,0.008293872,-0.034274947,0.027705463,-0.06154255,-0.02334817,-0.102733016,-4.7088407e-34,0.024467822,0.07532454,-0.024092998,-0.044758074,0.031051327,-0.0070862863,-0.01369635,-0.08537021,-0.008730882,-0.0373253,-0.058926817,-0.09320271,-0.006193286,0.06725096,-0.05948319,-0.04341416,-0.003728282,0.050685834,0.006589054,0.04873074,-0.041111864,0.090291284,-0.053732745,-0.024646735,0.06286236,0.018302437,-0.004532108,-0.0010938977,0.023248143,-0.022312356,-0.031288303,-0.014162872,-0.0581143,-0.040170398,0.055844117,-0.022617703,0.015474177,-0.049872976,-0.011464163,0.056067806,-0.009632464,-0.010771651,-0.061524265,-0.00952766,0.015041857,0.05887184,-0.099439144,0.09190267,0.059286177,0.022981301,0.08425194,-0.021510225,0.097042836,-0.049405064,-0.045747623,-0.025035001,-0.109566145,-0.03623906,-0.004468358,0.020039719,0.04366301,-0.024080904,-0.043847498,0.06591625,0.013234726,0.022956036,-0.07723029,-0.07094917,0.016736446,0.029415708,-0.114097714,-0.008021599,0.03119622,0.042526037,0.065918125,0.010194015,-0.118264146,-0.053110156,0.034350317,-0.004098184,-0.073846795,-0.0067529576,-0.033276275,-0.040463947,3.2771597e-05,-0.03242371,0.0039389427,-0.094727024,-0.049670693,-0.029436918,0.02305592,-0.063070215,-0.10970639,0.049948856,0.03203105,-2.0456691e-33,0.07641899,-0.016840843,0.0028324618,-0.05355527,-0.10890874,0.10543947,-0.0076655843,-0.069383495,0.13455015,0.07151248,-0.005789385,-0.012096219,-0.03668475,-0.031913415,-0.07635185,-0.04659996,0.025647711,0.120819144,-0.02760732,0.0031080453,-0.02832362,-0.033521548,-0.00044324461,-0.033980608,0.017336082,0.04981586,0.013550123,0.0637126,-0.0034831024,0.06842436,-0.03453051,-0.0112456335,-0.05594688,0.006150163,-0.07211184,0.122917935,0.022473508,-0.07018516,0.034687307,-0.059287906,0.038689263,-0.05525857,0.09206141,0.10327903,-0.013848054,-0.02043971,-0.030429486,0.09280357,-0.044026386,-0.1107966,0.030287798,-0.03699196,0.02375695,-0.0072878078,-0.020444304,0.026971836,-0.005110919,-0.048871968,0.06748339,-0.018724525,-0.0021433437,-0.02668506,-0.0092688585,0.041446846,0.02163033,-0.03185502,-0.024002561,0.06351342,0.061799318,0.0041622,0.036566373,0.07339822,0.03705704,-0.0005839814,0.01006468,0.023214212,-0.04178838,-0.07724137,0.042253915,-0.017423486,-0.003029497,-0.03921579,-0.042764258,-0.022173587,-0.08054153,-0.023156684,0.05301239,0.06968174,0.0077372757,-5.4861797e-05,-0.024188407,0.027430966,-0.0148269655,0.11406811,-0.014901294,-3.3076013e-08,0.06392527,0.010251552,0.034323487,0.0061563863,0.0031835637,0.06027049,0.023547545,-0.0073230546,0.052195333,0.008816712,-0.046181202,0.05067759,-0.010567459,-0.030851627,-0.020991044,0.11836974,-0.08687922,0.027193986,0.004175543,-0.030244645,-0.040343683,-0.033790946,-0.07103127,0.031984616,0.06149514,-0.10805716,-0.0014734184,0.05377638,-0.062208254,-0.013402573,0.05554238,-0.03624405,-0.029437147,-0.074120305,-0.014256289,0.044701263,-0.076421075,-0.084924705,0.06477076,0.017501662,0.0134461215,-0.028730743,-0.056396887,-0.020472609,-0.013153894,0.062029682,-0.052354284,0.016488709,-0.094945215,-0.05403906,0.059792925,-0.008500531,0.010070274,-0.030919963,-0.109150976,0.025614392,-0.019572698,-0.05582626,0.017404595,-0.047096137,-0.048858803,0.120178975,0.14118506,0.042834286 +1.14.21.1,A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the second methylenedioxy bridge of the protoberberine alkaloid stylopine from oxidative ring closure of adjacent phenolic and methoxy groups of cheilanthifoline.,384,1.0,-0.040903423,0.0043418948,-0.065761134,-0.00035630254,0.03253539,0.069328934,-0.029162582,0.07030573,0.031672683,-0.015783101,-0.02536575,-0.03613166,-0.07829401,-0.05486992,-0.04360405,0.093194924,-0.098427966,0.0326194,-0.051703177,-0.06887188,0.013975612,0.05604578,0.03010959,0.02257829,-0.0142741995,0.026400687,0.061120972,0.054250605,-0.016680393,-0.021968888,-0.0038452854,-0.011256864,0.020412318,-6.226853e-05,0.0062538134,0.068014026,-0.07688071,-0.02724123,-0.011373218,0.011976537,0.057291552,-0.0637212,-0.10961629,0.027434338,-0.052991576,-0.070240855,0.0037751806,0.03724113,-0.04743464,-0.024445346,-0.047936272,-0.031233154,-0.09906654,0.055772882,-0.04361726,0.04337879,0.04652973,0.00473077,-0.0082660355,-0.0063748034,0.056506805,0.012772545,-0.051072907,-0.013601757,-0.00046227736,-0.054318722,0.033982247,-0.0288878,-0.01044848,-0.08313301,-0.045771398,-0.03833729,-0.02024389,0.02025529,-0.013275188,0.030292332,-0.028400598,-0.014326673,0.015427413,-0.024524068,0.07171731,0.041841496,-0.05948143,0.09305568,0.03616468,0.034086015,-0.0422005,0.028080342,0.025870148,-0.05984888,-0.0042021084,0.002248797,-0.058685694,0.00017034909,-0.120319314,0.015681652,0.05039415,0.024275526,0.0022868465,0.0038726658,0.01822429,0.041043192,-0.05018775,-0.09697096,-0.052121766,0.019325439,-0.023317488,0.020431707,0.052846726,-0.02227024,0.0015499311,-0.077166,0.01857932,-0.0046009375,-0.002433201,0.11853717,-0.046281602,-0.033074845,0.014511959,-0.026944034,-0.039683178,-0.02490455,0.036766704,0.009521203,-0.078808114,0.0032032288,-0.06363783,7.290799e-33,0.08997566,0.054195516,0.0007774556,0.038780313,0.029228585,-0.039293613,-0.14753601,0.010821194,-0.049594034,-0.009255492,-0.07735713,-0.05702726,0.002245341,-0.053989924,0.03956884,-0.0598417,-0.11925889,0.04322765,0.0435387,0.021291178,-0.04238522,0.0020888995,-0.035242517,0.039715033,-0.001991879,0.069065735,0.02775072,0.0035301847,0.03218877,0.021755753,-0.043276627,-0.06014002,-0.022548018,-0.06747183,-0.06634217,0.020958642,-0.050765246,-0.046822917,-0.04418968,0.050866462,-0.048673373,0.0097872745,0.03577032,-0.024770236,0.06954443,-0.0801017,-0.098769076,0.07638577,0.048206173,0.08693372,-0.005124806,-0.040805053,0.12950455,0.07155264,-0.10089074,0.014660598,-0.040556,0.010131039,0.051394824,0.054630328,0.08127673,0.039516546,-0.0009398941,0.04070561,0.010617658,0.083081275,-0.028028408,-0.023683596,0.03392569,0.1016663,-0.056257315,0.030543515,0.026738904,0.02356082,0.002231555,-0.044123136,0.016431535,0.100275874,0.09369772,-0.004539259,0.028882585,-0.025710573,-0.03788202,0.024777794,0.0016768557,0.0020613119,-0.0019964948,-0.021317238,-0.05904936,0.052093375,-0.0042871227,-0.07385542,0.016438495,-0.039853204,0.030435037,-6.2329354e-33,0.09035345,-0.08973305,-0.003113205,-0.086810194,0.019108333,0.027183264,-0.04690942,-0.050065972,-0.075183734,0.005132351,0.09259636,0.010720813,0.052467298,-0.03920143,0.0385051,-0.07406372,0.050851807,0.040986136,0.025351612,0.03158188,0.072844,0.007991484,-0.07473151,0.013597144,0.04242813,0.008675827,-0.006264674,0.0077523706,0.0630324,-0.0024041042,0.017647458,0.008001113,-0.056693487,-0.028463027,-0.043554604,0.112772726,0.028030384,0.08430616,0.05188989,0.060821567,-0.017030267,0.0060526477,0.03107514,0.057051387,0.04202577,0.07158884,-0.14726305,-0.05201471,-0.0011530898,-0.07551985,0.07225644,0.091225706,-0.07238625,-0.03089587,0.01805316,0.063874595,0.008314613,-0.034524035,-0.04805112,-0.07207621,-0.040632434,-0.018660394,0.05468175,0.021447368,0.013565198,0.06251728,-0.032146707,0.029306391,0.07171412,-0.0016390851,0.02311996,0.027952414,-0.009369671,0.059323207,0.009744352,-0.03503016,0.0029467824,0.0130718965,0.06644897,0.030667346,0.0040420843,-0.04086996,0.03685854,-0.07726231,-0.017315676,-0.11036289,-0.030239401,0.12265184,0.058082987,0.020371143,-0.011109203,0.0395227,-0.068345904,0.03972198,0.05071085,-4.0534317e-08,-0.004331106,-0.09014662,0.050088365,0.040102627,0.015310276,0.0057028495,0.060479365,-0.044781253,0.052719608,-0.07006728,-0.0047598155,0.046742313,-0.0107074175,0.0134582585,0.03667987,-0.0016730769,-0.018209768,0.019958032,-0.023273254,0.009750365,-0.06238342,0.043492645,-0.0316266,0.010372369,0.03474049,-0.075749904,-0.029043535,-0.010646257,0.023056073,0.024405062,0.046439886,0.07840392,-0.044497177,0.0131222475,0.024811903,0.012726904,-0.022197042,0.003775759,-0.0722215,-0.02041243,0.016858151,-0.049868982,-0.0781506,0.015413922,0.06610714,0.031815853,0.03259925,0.03372188,-0.02015692,0.007463419,0.015855454,0.035194665,0.01936316,-0.08409284,-0.1717326,0.036872067,0.041083734,-0.021828981,-0.052450407,-0.12762508,0.04635548,0.008734655,0.21648397,0.022565445 +1.14.21.2,"A cytochrome P-450 (heme-thiolate) enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline by the oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine. cf. EC 1.14.21.12, (S)-nandinine synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-nandinine.",384,1.0,-0.08705554,-0.024099208,-0.08693285,-0.019695362,0.05498335,0.093204014,-0.04645754,0.071618035,0.0016817526,-0.003366024,-0.031608168,-0.008669153,0.015144963,-0.019712746,-0.0851725,0.07776379,-0.13096899,0.049917333,-0.012018416,-0.021865658,-0.019909156,0.027857332,0.05525825,0.03281214,-0.008615013,0.017309839,0.04066314,0.065151244,-0.0049590156,0.030391205,-0.0019904163,0.030600006,-0.0030878587,-0.013488861,0.02374947,0.036533613,-0.014732885,0.0004804273,-0.00015287123,0.041362975,0.034818582,0.008520632,-0.09463654,0.030953838,-0.052454717,-0.050761808,-0.021936959,-0.013413514,-0.055024553,-0.05366832,-0.071169235,-0.020806748,-0.086163014,0.022262663,-0.02255356,0.025347743,0.005458307,-0.06549778,-0.009593438,-0.0034424113,0.055801854,-0.042178594,-0.0013355471,-0.01312177,0.059044566,-0.051495403,-0.016424412,-0.038165994,-0.00793217,-0.070443705,-0.049609665,-0.08081361,-0.03143574,0.049302954,-0.07927931,0.020385776,0.0006809159,-0.012324523,0.002543071,-0.0026631847,0.001404503,-0.012723594,-0.08941253,0.07884439,0.071267076,0.02669182,0.00089512666,0.06895047,0.06479608,-0.0015786107,-0.018411614,0.022954673,-0.055678885,-0.021609882,-0.15855646,-0.020194044,0.04179308,0.077744745,0.0016849362,-0.0047265794,0.052832097,0.0596618,-0.04024875,-0.09349719,-0.021087058,0.042057443,0.010343142,0.06723856,-0.00731191,0.008525265,-0.0016615387,-0.07511694,0.026022224,0.01041085,0.0054179053,0.09856324,-0.028839516,-0.030898754,0.017329326,0.014009405,-0.025609503,0.0029590868,0.021976858,0.029779406,-0.04980223,0.0027288676,-0.06987853,4.2672774e-33,0.076058134,0.10179736,0.009888691,0.040764917,0.029699601,0.0025667557,-0.12345288,0.07402496,-0.05544837,-0.024274884,-0.10598786,-0.0032134661,0.019058524,-0.035275042,-0.012943681,-0.048753433,-0.1269966,-0.014164637,0.029189441,-0.02921526,-0.04828039,-0.023758395,-0.049610615,0.009331653,-0.006924941,0.002554683,0.017272672,0.004667354,0.0036461155,0.012182795,-0.026589286,-0.11294145,-0.025457155,-0.07326323,-0.06284357,0.005012956,-0.0054441234,-0.019662943,-0.028438807,0.0639352,-0.06288861,-0.02541369,0.023317706,-0.017777003,0.0547124,-0.044576824,-0.089593045,0.09759848,0.043679282,0.027656592,0.00058542984,-0.08026146,0.08419899,0.03772534,-0.10447014,0.041327756,-0.02312966,-0.053193767,0.0150257815,0.07267974,0.070222124,0.02280396,-0.015006658,0.016522042,0.05022028,0.059668735,-0.0233931,-0.0372028,0.030328665,0.053461637,-0.08347584,0.031177636,0.09514858,0.045761738,0.00055503205,-0.012360911,-0.02563011,0.055727616,0.0779938,0.037231877,0.01769306,0.014737052,-0.053406436,0.056168154,0.019118883,-0.03202458,-0.013804131,-0.054170858,-0.034340523,0.068761714,-0.0005768868,-0.13246363,-0.0032618789,-0.0038212657,-0.008331829,-3.9085768e-33,0.05133639,-0.079716556,-0.008484098,-0.08377051,0.009219795,0.017407173,-0.0069799013,-0.011925956,-0.02895646,-0.0055430857,0.114105254,-0.024693018,0.08087403,-0.06598859,-0.011274099,-0.092467055,0.05938616,0.038723033,0.0029128047,0.014594543,0.053686187,0.029653804,-0.067443155,0.0062498855,0.021716686,0.07226829,0.015288788,0.020326179,0.058607273,0.06903646,0.012623107,-0.019722445,-0.05827887,-0.0490164,-0.0044192327,0.13503721,0.021251475,0.067734115,0.04121456,0.053086605,-0.02976545,0.023122236,0.02969071,0.0658428,0.06735181,0.07402222,-0.119092986,-0.010034028,0.007986563,-0.067044936,0.06263164,0.061496086,-0.084407665,-0.005141355,0.026876241,0.06784822,-0.002371824,-0.04585005,-0.05490037,-0.03949178,0.0065576914,-0.024368454,0.012731706,0.0001620986,-0.004328208,0.053313054,-0.08973456,0.059910536,0.10938665,0.00434226,-0.018343406,0.0016905229,0.02534884,0.058346644,-0.014546311,-0.011865245,-0.022799885,-0.016935244,0.041947637,0.017787544,-0.0017365161,-0.038671024,0.028292177,-0.042606056,-0.012023925,-0.07239319,-0.04364253,0.07949905,0.07299827,-0.06174997,-0.008374149,0.036596186,-0.09051809,0.06589971,0.0042453404,-4.4024418e-08,0.016666325,-0.07304862,0.07033105,0.024892678,0.037542187,0.02184204,0.046589006,-0.0677872,0.102048084,-0.06295176,0.0071405056,0.05842643,-0.01633737,-0.0124128,0.027139796,0.037901737,-0.039944783,0.010451646,-0.0047087166,-0.011148135,-0.05697277,0.043527894,-0.06089955,-0.00019267763,0.010373235,-0.06190521,-0.042756658,0.028620305,0.034706876,0.026031733,0.062036306,0.0188815,-0.024618316,0.055214614,0.028242221,0.023566399,-0.03178979,-0.017006328,-0.034222655,-0.04985605,0.026876362,-0.04138289,-0.096301354,0.04855738,0.097522184,0.024051616,0.03320353,0.05787919,-0.021150481,0.009531184,0.0034361703,0.03178044,0.03695069,-0.091326825,-0.117202714,0.038901705,0.009778968,-0.05223908,-0.076124914,-0.10009668,0.03994822,0.043695834,0.22472523,0.023856902 +1.14.21.3,A heme-thiolate enzyme (P-450). Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine.,384,1.0,-0.02176041,0.028631689,-0.0491805,-0.015946269,-0.04068429,0.055599805,0.007927731,0.09472676,0.042125765,-0.0024039352,-0.008856735,-0.054315597,-0.022437789,0.022793496,-0.06372644,0.043946836,-0.023892405,0.015265529,0.0050223395,-0.12480035,-0.04417411,0.06409496,0.056613524,0.082057565,0.013305852,0.010505456,0.030879864,0.055083886,-0.019539902,0.00019751817,0.028224265,-0.01954044,0.06282418,-0.0074984026,-0.029354673,0.061738223,-0.10136537,-0.00017156167,0.014071443,0.02330442,0.053443387,-0.051656544,-0.09417967,0.05525204,-0.02489291,-0.013999612,0.0031349557,0.10794343,-0.00034131453,0.042802975,0.010026428,-0.074460596,-0.11418552,0.094990745,0.012999201,0.03345584,-0.004679961,0.07812147,-0.020165943,0.0689665,0.0229185,0.05874864,-0.023483953,0.016097438,-0.040812988,0.028587122,-0.0044593485,-0.023104997,0.032859825,-0.062041856,-0.0028623017,-0.07542059,5.5357108e-05,-0.032257725,-0.03547215,0.0109193735,-0.03650888,0.00040596523,0.0154055385,-0.049177367,0.06468336,0.0077113826,-0.024692815,0.014456686,0.040004887,0.04333267,0.0340294,0.025373986,0.02213491,-0.07490316,0.07460684,0.00018673079,-0.057023894,-0.1062756,-0.052462228,0.08793986,-0.024871169,0.026783694,0.022593908,-0.010374738,0.059643548,0.0004663966,-0.11250341,-0.08941976,-0.06860652,0.081479385,-0.01028727,-0.037975963,0.016966881,-0.036334895,-0.05156587,-0.050934564,0.058323253,0.0033483815,-0.010270699,0.11986593,-0.0026737058,0.005794401,-0.052324325,-0.044746965,-0.0043045017,-0.036304567,0.04272898,-0.011326768,-0.046509303,0.04099757,-0.0032780697,5.7207464e-33,0.07201031,0.05358341,-0.014344263,0.048699655,-0.009509709,-0.013808292,-0.04555482,0.05317009,-0.11041567,-0.0057043512,-0.045232117,-0.09825608,0.017641697,-0.004816959,0.0033006612,0.0062652295,-0.08038785,0.05659025,0.039903548,-0.052790802,-0.09228365,0.048322234,-0.068344206,0.0009987858,-0.03545743,0.096634865,-0.026489152,0.047098868,0.05076199,-0.033430398,-0.0031345028,-0.058176495,-0.09908544,-0.025955824,-0.063539386,-0.0098595135,-0.031044457,0.026937785,-0.04051659,0.04781467,0.0083609205,0.05603532,0.026509343,-0.017871456,0.07024523,-0.016156677,-0.050947934,0.09119991,0.09992309,0.05672987,0.034233894,-0.0048739896,0.11143128,0.022492927,-0.071976006,0.06889907,0.03393283,0.026271617,0.057061538,0.024124078,0.03760183,0.057674404,-0.04196323,-0.041514855,0.00064355455,0.029563406,-0.06404485,-0.016344758,0.021449208,0.061488416,-0.00908056,0.0146485865,0.03086115,0.0027704667,-0.0063073337,-0.021535626,-0.029271228,-0.033794757,-0.0012022821,-0.06477905,-0.010750184,0.013122818,0.046001866,0.027433597,-0.048534073,-0.0019068248,0.011511215,-0.06547582,-0.06604137,0.0164828,0.0518095,-0.014338311,-0.031294443,-0.026112884,0.026704216,-4.2926853e-33,0.08607132,-0.065137476,-0.019917462,-0.058961365,-0.034843974,0.020669188,0.031225389,-0.013449071,-0.032937434,0.014954141,0.10717141,-0.04358495,0.027382445,0.0060402118,0.07194541,-0.0389811,0.0068986365,0.092828214,-0.0049161958,-0.0020610234,0.015047421,0.06307782,-0.01845001,0.030220175,-0.0015643005,0.05302511,0.017311841,0.0011606412,0.13041638,0.080791794,-0.07649482,-0.014402063,-0.060360957,-0.027711336,-0.016465554,0.023335239,0.057870805,0.030688293,-0.062403556,0.025988765,-0.022590777,0.033159908,0.013387166,0.07846172,0.055210765,0.06819028,-0.067572586,0.037938844,-0.040300623,-0.02286397,0.08053516,-0.002924356,-0.034729313,0.01916234,0.0430495,0.032743633,-0.013717259,-0.07922149,0.0064669265,-0.11098693,-0.041095696,-0.063413635,0.020699061,-0.043311138,0.012455384,0.08598121,-0.035383698,0.069561675,0.02026366,-0.041229825,0.06666665,-0.01949482,-0.0043240716,0.022610003,-0.07845514,-0.038351137,0.017106475,-0.03510134,0.06781074,0.026287077,0.036638346,0.018573409,-0.0031321533,-0.089358434,-0.0129354745,-0.0924455,-0.009768359,0.12183634,0.061595507,0.0510725,-0.05433334,0.06516798,-0.04986742,0.052549195,0.098216705,-4.197512e-08,0.014486248,-0.08844365,0.024916925,-0.013278487,0.033189274,0.008963208,0.055503175,-0.00973449,0.053664483,0.019311534,-0.016153947,-0.0026094273,-0.041024107,0.090985365,0.010951302,0.015597551,-0.036020115,0.010573668,-0.041347098,-0.034487925,-0.10063436,0.07579911,-0.03577354,-0.074632235,0.028200407,-0.100591406,-0.032201152,0.023057567,-0.00784242,0.020147553,-0.018256316,0.054613847,0.0040496318,-0.05305342,0.002564712,0.045851503,-0.024739048,0.06539664,-0.0128421765,-0.031436507,-0.06424642,-0.055130932,-0.05646784,0.0068089035,0.058266625,-0.06892375,0.054048643,0.016576054,0.0049305754,0.010477009,-0.0069531268,-0.026081162,0.049361594,-0.122183815,-0.14707336,-0.027725432,-0.05081405,-0.04254646,-0.038476206,-0.1522441,0.003972015,-0.031319052,0.19798395,-0.011996845 +1.14.21.4,A heme-thiolate enzyme (P-450). Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.,384,0.99999994,-0.0023318664,0.010062156,-0.026896274,0.037125733,0.05028459,0.06773455,-0.011165118,0.10076701,0.031634312,0.0019931041,0.0036716491,-0.015336822,-0.04434649,0.05629683,-0.0334948,0.065074265,-0.08110953,0.063154325,0.018062996,-0.07136899,0.055378392,0.09262311,0.023703838,0.035125144,0.0147401905,-0.019265106,0.044130627,0.068645015,-0.015243335,-0.095534526,0.024701174,-0.05624811,0.004087947,-0.0147926705,0.0019583541,0.08570134,-0.08360415,-0.028373115,-0.02366319,0.043389857,0.066221654,-0.040482465,-0.13987297,0.02615024,0.017573487,-0.054332294,-0.021995477,0.03634131,0.006457923,0.024607003,-0.01783791,-0.06675281,-0.083308555,0.079481445,-0.049291506,-0.05680016,-0.016354674,-0.005188415,0.03581134,-0.0021131244,-0.024748784,0.030634064,0.0099680815,-0.06608267,-0.024412755,-0.07070513,0.015804663,-0.064043984,0.0135576455,-0.110276714,-0.016433565,-0.10730255,-0.03151908,0.0010537221,-0.019747123,-0.007508158,-0.036570296,-0.024491625,-0.055790722,-0.038435753,0.10851937,0.017039077,-0.08649279,0.10570948,0.06295578,-0.015824195,-0.010112027,0.031111212,0.020134374,-0.05043164,0.0050695697,0.024538223,-0.04408943,-0.046003826,-0.046647187,0.02623058,-0.050237607,0.054798085,-0.020401902,0.016722359,0.050129384,0.009679905,-0.1382761,-0.062721305,-0.044975143,-0.0074977553,0.008558192,0.0093755275,-0.004121695,-0.08156806,-0.0047967606,-0.0069339727,0.050402123,-0.012597775,0.020179344,0.10147043,-0.026562104,-0.011776597,-0.063889995,-0.05847865,-0.056353893,-0.023488332,0.05839999,-0.0094779385,-0.033234358,0.02527174,-0.044510342,3.8871027e-33,0.0535319,0.067099586,-0.028253721,0.05170095,-0.052876666,-0.062484164,-0.052809175,0.05902997,-0.01387627,-0.06974926,-0.05723783,-0.048081573,-0.012970327,0.008786431,0.02177824,-0.061118424,-0.033624727,0.028045934,0.041443117,-0.044219036,-0.1036496,0.035148706,-0.04175197,0.030566616,-0.0143711325,0.061313797,-0.004931992,0.025810812,0.035065062,-0.020461066,0.03608055,0.006778599,-0.015404271,-0.010799507,0.040691376,0.0060932124,-0.006451087,0.0065402896,-0.039246347,0.029688958,-0.014147633,0.049639735,0.024392122,-0.004995183,0.06798421,-0.019138535,-0.12843177,0.13046664,0.035573594,0.056393277,0.0064791944,-0.0010599798,0.14968123,0.03317207,-0.08819257,0.023170637,-0.021710182,0.005387734,0.06203076,0.023774624,0.08192258,0.0814047,-0.081719115,0.05804291,-0.011392736,0.028261965,-0.022150094,-0.0011563454,0.053204067,0.0765536,-0.02627324,0.054275203,-0.009457932,0.019353164,0.005989694,-0.058160573,-0.05170245,0.095992215,0.022919498,-0.039764896,0.016590629,-0.02130448,-0.020029077,0.0274651,0.0038043095,-0.024027389,0.060149103,-0.013747604,-0.020989742,0.01753503,0.03541116,-0.016050883,-0.021170987,-0.0033033658,0.023461087,-2.609092e-33,0.13513449,-0.10109233,0.009959567,-0.041166496,-0.032965735,0.018822558,-0.0004881695,0.061513208,-0.054602776,0.014774981,0.111437365,-0.041962028,0.04391186,-0.026331585,0.054807507,-0.036504295,-0.03906356,0.04562831,-0.021326473,0.025075674,-0.07712391,0.08011965,-0.009601193,0.035796214,0.03861772,0.07378467,-0.026456786,0.031778753,0.06417726,-0.0056458884,-0.02645217,0.03822438,-0.06747608,-0.08417081,-0.05008219,0.057892445,0.04242138,-0.007867534,-0.028931968,0.03308157,-0.00010111458,0.05208793,0.043456636,0.05244046,0.06783876,0.0941266,-0.042127036,-0.016883802,-0.026648013,-0.11000698,0.07050085,0.020355409,-0.019277181,-0.04318613,0.006223233,8.9109557e-07,-0.03910557,-0.031460017,0.0025543827,-0.10559536,-0.008058113,-0.04229805,0.030293679,-0.00077183667,-0.018133415,0.05070235,0.04063985,0.032614246,0.08891435,-0.054183695,0.0014091554,0.010560234,0.054659504,0.010780282,-0.043869276,-0.02102067,-0.0019389582,0.019038143,0.08134351,-0.022800395,0.02537168,-0.003334725,-0.037353937,-0.072901696,0.029291919,-0.07949785,-0.0569532,0.07658608,0.024053788,0.0067573567,-0.03997722,0.00847827,-0.038125906,0.10904035,0.07030027,-3.5138616e-08,0.042092953,-0.068838626,0.0685481,0.004268058,0.008896383,-0.014678589,0.08067784,-0.007959923,0.041430414,-0.01355914,-0.015288277,0.05293895,0.0027045084,0.0034611004,0.039256305,0.019532844,-0.014755567,0.12089881,0.016081631,0.0030707833,-0.048458207,0.0341576,-0.016876878,0.056293704,0.03800594,-0.072825685,-0.01242427,-0.062460423,0.010454797,0.019335477,0.056536432,0.0346356,0.02450584,-0.022475217,0.0059458828,0.039728165,-0.030989854,-0.01390957,0.013436853,-0.024829078,-0.0020580543,-0.052399356,-0.068095125,-0.010119337,0.037965167,-0.058449168,0.014972229,0.0033514677,-0.0405145,-0.027110647,0.018184073,-0.024826286,-0.0040238323,-0.10018456,-0.15196835,-0.03526015,0.03737284,-0.09064671,-0.07376998,-0.16585585,0.06668094,0.039700884,0.20501526,0.017291872 +1.14.21.5,A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that does not incorporate oxygen into the product. Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.,384,1.0,-0.0710898,0.03285436,-0.08901899,-0.01660113,0.039480038,0.02480869,-0.06568656,0.05546269,0.0348853,0.012414357,-0.022247884,0.011559039,-0.027244471,0.0034691782,-0.06354529,0.08905237,-0.095235564,0.033238415,-0.005704677,-0.049571585,0.0227367,0.031219346,0.04787394,0.015052553,-0.0065846094,0.053371366,0.03794063,0.08098273,0.0022277515,-0.052809745,-0.033649426,0.036726248,-0.02216924,0.011735797,-0.04494602,0.10166705,-0.09109648,-0.044765856,-0.008200373,0.007624543,0.021802219,-0.100476705,-0.11453397,0.021378305,-0.059957277,-0.1025826,-0.01963155,0.033138156,-0.04625209,-0.007762603,-0.01466463,0.0119674215,-0.02277563,-0.004909336,-0.025227316,0.002543581,0.005737325,0.043357156,-0.025557918,0.02463073,0.04647038,0.0046282024,-0.044492207,0.01112806,0.0027965293,-0.054730058,-0.011433575,-0.03669995,-0.06174752,-0.07884113,-0.027238287,-0.06230133,-0.025682297,-0.009736615,-0.011867424,0.019294748,-0.010142761,0.008120995,0.0041342885,-0.0031334576,0.034057446,0.032504726,-0.08738158,0.08876815,0.05572121,0.026394898,-0.041838955,0.078285106,0.0018465628,-0.04618311,-0.025193874,0.025122656,-0.04448228,-0.024367062,-0.06724182,0.07148835,0.05487955,0.06971442,-0.018419255,0.009692097,0.030117119,0.052408252,-0.11558674,-0.079195105,-0.0640706,-0.015432634,0.018103391,0.016668947,0.056202795,-0.021152765,-0.03196092,-0.073801994,0.05737497,0.02704302,-0.01346276,0.11367538,-0.012240315,-0.036495846,-0.036295,-0.07154201,-0.035621345,-0.032744274,0.006767578,0.009237374,-0.07594362,0.050126873,0.001751434,5.2055213e-33,0.10013396,0.092530094,-0.03668097,0.0072213383,0.004682267,-0.0038694907,-0.08399155,0.059129912,-0.017810274,-0.0115843415,-0.06687789,0.00316789,0.019486837,-0.056577504,0.032983582,-0.08543258,-0.07380486,0.031484917,0.05215972,-0.018562092,-0.07776727,0.01901554,-0.053053323,0.05944775,-0.0698634,0.07211569,0.0061496943,-0.033042587,0.054733936,-0.0064199967,-0.03214217,-0.0345176,-0.050875723,-0.05389139,-0.09756939,0.030498078,-0.050669253,0.010515929,-0.04909328,0.03657953,-0.0028896667,-0.0010833491,0.032963257,-0.04838055,0.0050427835,-0.027636914,-0.07425283,0.09604881,0.03342885,0.040071025,0.010979572,0.030423798,0.10391561,-0.00044147836,-0.06580078,0.031310707,-0.0136695905,-0.00041349133,0.021921517,0.06914291,0.03910653,0.022837626,0.006887647,0.060576398,-0.023424022,0.02956319,-0.026490333,-0.043758377,0.05384802,0.07218149,-0.041798223,0.08237212,0.04366529,0.02025663,-0.035511535,0.015301905,0.0102013135,0.05311581,0.07788722,-0.040507894,0.029056221,-0.009233469,0.007727205,0.044922207,0.022747992,0.010974432,-0.0014545234,-0.06460215,-0.064049646,0.05196834,-0.017648214,-0.097584866,0.024024386,-0.056711096,0.035930905,-4.467361e-33,0.09949264,-0.08776294,-0.02330591,-0.10804047,0.02089178,0.019362228,-0.033611264,-0.05169793,-0.0633809,0.02660957,0.10507526,-0.021191927,0.06440257,-0.03198319,0.041620545,-0.07299462,0.021978365,0.05735731,-0.030709747,0.02651007,0.026825286,0.07770513,-0.036228895,0.02905456,0.0062962966,0.08120559,0.015092786,-0.03152493,0.05352444,0.016642999,0.01260601,-0.009773578,-0.055499356,0.012880253,0.03275204,0.120842926,0.059617266,0.031887174,-0.001972035,0.02722932,-0.03562711,0.034180198,0.03322958,0.042207126,0.04392791,0.0561188,-0.13099918,-0.09144266,-0.005774143,-0.03640468,0.08338241,0.108448856,-0.07810539,-0.0106802825,0.023986394,0.034362823,-0.0025584595,-0.06325297,-0.041799143,-0.1148012,-0.05375647,0.027904931,0.028476113,0.028822854,0.011242016,0.029295694,-0.08601357,0.052605327,0.03140915,-0.008658838,0.02321105,-0.006843786,0.036704108,0.06670663,0.0324666,-0.038942683,0.03501645,-0.01909854,0.06874249,-0.03489559,-0.041179966,0.0030059058,-0.00047418696,-0.09520311,-0.022684168,-0.08593649,-0.022107946,0.10904756,0.044538993,0.019085517,0.0020973615,0.048646618,-0.092573196,0.07979613,0.09568394,-3.9587864e-08,-0.009168992,-0.098226696,0.04987024,0.048511162,0.03459788,0.039050486,0.08594964,-0.007334839,0.07377035,-0.050608262,0.019806517,0.038429245,-0.021329269,0.03144686,0.008572082,0.0049822754,-0.025596151,0.012847588,-0.012632529,-0.038311344,-0.097299196,0.035221457,-5.4361244e-06,-0.0041778954,0.017148215,-0.06845707,-0.079034865,-0.050440982,0.05894592,0.018910654,0.012238425,0.057939563,-0.03269269,0.01951879,0.020874744,0.03160204,0.037082803,0.02839821,-0.0356918,-0.018501807,-0.03641909,-0.040503282,-0.06581753,0.041153662,0.059026003,-0.016447717,-0.017298058,0.03477227,0.02583786,0.009874871,-0.0195323,0.027190369,0.05242316,-0.10964333,-0.12623149,0.016611645,0.017189277,-0.0056200195,-0.037781425,-0.111148365,0.059695195,0.037715204,0.22285831,0.019384634 +1.14.21.6,"This enzyme catalyses the introduction of a C5 double bond into the B ring of Delta7-sterols to yield the corresponding Delta5,7-sterols in mammals, yeast and plants [4]. Forms part of the plant sterol biosynthesis pathway.",384,1.0,-0.07203772,0.01225034,-0.08214388,0.006714089,-0.019869281,0.061681084,-0.07976625,-0.019726325,0.018423695,-0.003371964,0.030304907,-0.032201957,-0.15803736,-0.06687079,-0.0042684157,0.0018855673,-0.100120105,0.06533857,-0.0037210376,-0.101434775,0.03883714,0.024820494,-0.020506598,0.0044646217,0.024721468,0.02431142,0.021549404,0.00689142,0.0245942,-0.13807309,-0.039004136,-0.008430978,0.03255489,-0.04853653,-0.008809962,0.041600995,-0.0080517735,-0.07416253,0.056297205,0.035105057,0.07532646,-0.032891143,0.05518325,-0.023024054,-0.046212625,-0.02108116,-0.03242215,0.0040125125,0.04769599,-0.049745597,0.007812051,-0.059342567,-0.030389767,0.012016202,-0.039418098,-0.008706951,-0.014920513,-0.031422216,0.014172428,-0.017087366,0.06858018,0.0016975228,-0.05561747,0.013670667,-0.11963751,-0.047821432,-0.025824958,-0.015655732,0.045754455,0.016073972,-0.033157308,-0.028986044,-0.04432551,0.06300953,0.003999275,0.04311945,-0.016223393,-0.04755963,0.06400802,-0.04925075,0.0655212,0.02602287,0.018262748,0.073436186,0.059148043,0.00651929,-0.05611769,0.072032884,0.054326415,0.01612641,0.08375003,0.0065343184,0.032072548,0.021952333,-0.1433331,0.11464867,0.021105193,0.015837733,-0.031619523,-0.029288946,0.031216418,0.0543842,-0.04569794,-0.039906826,0.037276093,0.019153344,-0.05396192,0.06425615,0.025633398,-0.048458517,-0.013478566,-0.015028564,0.069895685,-0.00064182415,-0.024712238,0.038323592,0.0015278055,-0.027971037,-0.030492965,-0.04258418,0.0076688924,0.017255597,0.00034482664,0.015729062,-0.046469215,-0.028518261,-0.09327776,-4.1404727e-34,0.08137856,0.018657964,0.024732811,0.057492316,-0.038278323,-0.057324752,-0.030744055,-0.0353565,-0.0833734,-0.07352487,-0.059002247,-0.11912096,-0.007552238,0.020911587,-0.015248418,-0.015550621,0.07051488,0.027902585,0.07468872,-0.028134558,0.0043635145,0.13398777,-0.08802026,0.002817862,0.0793314,0.0018113928,0.019382099,-0.0029628729,0.026204227,-0.0007740163,-0.047970645,-0.0014770207,-0.012098749,-0.010498176,0.12262345,-0.008986097,0.043123063,-0.025124047,-0.046272647,0.08806879,0.052045252,0.019451046,-0.02943059,0.03889335,0.042607233,0.042252902,-0.082121566,0.051198434,0.13610148,0.08781488,0.008058437,0.021133544,0.08441351,0.0782774,-0.057429608,0.06789986,-0.020462882,0.029790001,-0.0034561162,0.031645365,-0.031701446,0.08965913,-0.07740578,0.06286948,-0.025827074,0.0015300028,-0.0296327,-0.076652244,-0.07510715,0.060815495,-0.07125995,-0.067727864,-0.0059389183,-0.01184802,0.07187463,0.018461617,-0.030224737,0.00938155,-0.021627441,-0.017211296,-0.08268344,-0.051645815,-0.0114594055,0.0025031983,-0.02399646,0.009184472,-0.025196383,-0.055348244,0.028832516,-0.033038106,0.03799268,-0.03672178,-0.04403675,0.058448706,-0.015629148,-1.4080373e-33,0.07803472,-0.077778295,0.0995607,-0.022300584,-0.104977086,0.040660445,-0.026564525,-0.12901758,-0.009963505,-0.01623112,0.020884765,0.013780867,0.03061882,0.026803866,0.011684697,-0.02832386,0.018761402,0.08905645,-0.053363096,0.011825094,-0.034520984,0.057939183,-0.011498206,0.13383454,0.017940616,0.015970137,0.06977444,0.02657077,0.043009777,-0.007829324,0.028814401,-0.06788896,-0.0021971173,-0.011284543,-0.07332443,-0.010726958,0.0062236856,0.01770738,0.033398952,0.013502477,-0.033607606,0.0013854236,-0.05185839,-0.038659822,0.04800685,-0.04305442,0.0032271338,0.04285203,-0.018246526,-0.030663084,0.009606041,0.01618468,-0.034473367,0.015584542,-0.00081260805,-0.02515218,0.039751437,-0.005592163,0.115995005,-0.028128631,-0.0069071585,-0.0076256776,0.047271498,-0.016869986,0.06618583,0.0698131,0.020299705,0.0007438092,0.024942448,-0.07449153,0.03849262,0.06876078,0.030582385,0.123809695,-0.0016096126,-0.005080592,-0.015826818,-0.10627021,-0.052707687,-0.0032988514,-0.06965342,-0.041333143,0.09026175,-0.069598734,-0.0790261,-0.05199411,0.05721092,0.07842737,0.06613293,0.0568293,-0.027521353,0.00609388,-0.031625614,0.09001216,0.06313189,-2.9180876e-08,-0.002330407,-0.024661807,-0.0031499867,-0.08769429,-0.06934878,0.01822475,-0.0096208695,-0.05732352,0.08442918,-0.0036701546,-0.060599927,0.06660579,0.041868486,0.044963025,0.008023184,0.046769418,-0.016471922,-0.025586229,-0.008198036,-0.0385359,-0.059477262,-0.029215403,-0.0048167473,0.0029356622,0.029859975,-0.12085197,-0.026704306,0.12317663,0.06513919,-0.03588432,0.027907437,0.0017353847,0.052331716,0.011342171,0.06040321,0.06180159,0.013447315,-0.0869204,0.051964704,0.1053051,-0.0068951445,-0.07049316,-0.022395562,0.023752494,-0.032741223,-0.042809214,0.02845289,0.08604766,0.0105065135,-0.010536989,0.027562806,0.01093331,-0.026771557,-0.06979776,-0.07557149,-0.039895136,-0.029279916,0.011517308,0.016610669,-0.025329228,-0.009742233,-0.02660477,0.13541639,-0.01156745 +1.14.99.1,This enzyme acts both as a dioxygenase and as a peroxidase.,384,1.0,-0.0692799,-0.0044363444,-0.12365256,0.013440534,0.030280994,0.005236321,-0.07481699,0.03234797,0.0071958625,-0.040902466,-0.0011987417,-0.021559952,-0.04275195,0.004752559,-0.036278315,0.09088225,-0.03820208,0.0019385214,0.00980927,-0.029016482,0.056006894,-0.0031564576,-0.0296012,-0.034767464,0.046852984,0.018599065,0.04227115,-0.008178199,-0.038117275,-0.05725475,0.040944193,-0.062306006,0.020738352,0.011352332,-0.05010782,0.10271797,-0.046215508,-0.04739724,-0.0066593094,-0.03909335,0.01565798,-0.0048527694,-0.08834736,-0.030341303,-0.025556777,-0.01306664,0.026446609,0.036136076,0.030457938,-0.0019364608,-0.047794957,-0.050964165,-0.066770576,-0.022202188,0.030944377,0.058762714,-0.06758872,0.0017755778,-0.058519937,0.020848554,-0.0076339673,-0.014836697,-0.009652575,0.097492464,0.04981891,-0.07162393,0.030135013,-0.05647342,-0.049837377,-0.1695994,-0.019612426,-0.057581473,0.034036208,-0.021731712,-0.023716507,-0.017751558,-0.052275594,0.0062336754,0.06278247,0.02077683,-0.0049343486,0.006648588,0.039472036,0.046305746,0.029894823,-0.0038099044,0.018073402,-0.016811116,-0.0119284745,0.027934045,-0.024200125,0.0017278731,-0.04109571,0.012081223,0.01411761,0.032545164,0.053637367,0.06605343,0.0023016077,-0.06020196,-0.030965794,0.067851745,-0.03413506,-0.06289435,-0.048728935,0.011738145,-0.01927572,0.056537833,0.039285704,-0.03912959,0.028518569,0.06228074,0.083412185,0.07402194,0.023580736,0.11853983,0.019103467,-0.036478743,-0.018525373,0.028882911,-0.013777001,-0.043600857,0.012045399,0.052345607,-0.027164415,0.022305787,-0.04552857,-2.0352175e-33,-8.463158e-05,0.0285342,-0.014666555,-0.02551594,0.03578673,0.022998823,-0.11834024,0.010393449,-0.028212896,0.0056715244,-0.057740893,-0.036846697,0.08138021,0.018955708,-0.018617053,-0.013309721,-0.019988842,0.011728651,0.053815365,0.015065809,0.039044164,0.06028532,-0.074873015,-0.021238858,0.006027897,0.06660644,0.04125845,0.010379939,0.0018377197,-0.012317244,0.01494833,-0.05781279,-0.064258926,-0.005720073,0.024896622,0.021734372,-0.057071917,-0.014483996,-0.059381578,0.016937867,-0.04254496,-0.009619003,-0.048340034,-0.083385274,0.08132615,-0.14245455,-0.0654374,0.108635195,0.044815186,0.09558653,0.04585866,-0.012196193,0.11986482,-0.05364768,-0.034338918,0.05730426,0.003374221,0.024619257,0.07283321,0.08169177,-0.0036526374,0.029777339,-0.082103655,0.012389385,0.06718685,0.003466305,-0.06298219,-0.017861672,0.002914808,0.12717032,-0.019999813,0.021451795,0.07089364,0.005997974,-0.0036651413,-0.05735245,-0.06921485,0.07234613,0.09748445,0.017641947,-0.0016393728,-0.0033850137,0.024019415,-0.054772038,-0.01944309,0.044509593,-0.03937127,-0.026070848,-0.02862087,0.037665416,0.07826147,-0.05748372,-0.08374831,-0.068311945,0.06636357,-6.849925e-34,0.070127234,-0.043664753,-0.050272495,-0.05206331,0.034794267,0.09004836,0.005251051,-0.0025782096,0.06273299,0.039167244,0.0050188606,0.014126597,-0.014291415,-0.053688645,0.024259787,0.052082594,-0.030681014,0.046344556,-0.08479804,0.010149299,-0.021781333,0.13219498,0.0104038855,0.060824536,0.04983432,-0.023557369,-0.027083628,0.08050452,0.03714213,0.053141616,-0.04079611,0.013480101,-0.019979194,-0.022752116,0.019182704,0.03399785,-0.10565044,-0.00046823482,0.051569775,0.00840954,-0.0112547325,0.027784498,0.019637499,0.12845299,0.024101468,0.08341644,-0.14534894,0.008872407,-0.0077945576,-0.10892627,-0.021498961,0.06558051,0.013812679,0.003388001,0.028823333,0.019010745,0.033828106,-0.03348436,-0.02853968,-0.032206193,-0.053911876,-0.075355224,0.056534197,0.010390306,-0.016791265,0.034948967,-0.066587955,0.021418344,-0.021814942,0.0048203804,0.06371171,-0.020597672,-0.041598666,0.011033617,-0.02575061,-0.07154542,-0.031361505,0.003368175,0.05059735,0.040195044,0.005912341,0.008970263,-0.0022428385,-0.09689072,-0.057305187,-0.08661177,-0.011268304,0.07899826,0.020848727,0.01045413,-0.015663566,0.027897932,-0.073630266,-0.035539817,0.12525506,-2.0874193e-08,-0.019409638,-0.087637186,0.12805237,0.0008788127,-0.024295388,0.052146103,0.044167522,0.010392516,0.006477844,-0.02707364,0.021806343,0.07904345,-0.022850608,-0.013562775,0.033531573,0.03914364,0.0037880747,-0.012173989,-0.004245498,0.013588386,-0.06777294,-0.024540601,-0.046690207,0.04731717,0.04019076,-0.05131356,0.010695548,0.0065281554,0.0015959055,-0.0053113042,-0.034591183,0.037947446,-0.025640965,-0.08085073,-0.14370464,-0.0084892595,0.057547748,-0.005020139,-0.010917321,-0.019039981,0.023012875,-0.0356601,-0.026374057,-0.010998358,-0.016240815,0.07124207,0.010016928,-0.049491365,-0.002229634,0.018836845,0.06926799,-0.056775656,0.029213224,-0.038324784,-0.1245143,0.03474272,-0.011768464,-0.08806044,0.0037120352,-0.042513885,0.04520639,0.07399356,0.25280446,-0.03970028 +1.14.99.3,"Requires NAD(P)H and EC 1.6.2.4, NADPH---hemoprotein reductase. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The central iron is kept in the reduced state by NAD(P)H.",384,0.99999994,-0.010389363,0.005969925,-0.12307208,0.003981405,0.06621012,0.03360033,0.017389063,0.024457872,0.07856701,-0.045317646,0.004001998,0.01818816,-0.099144295,-0.037655786,-0.019363064,0.044890556,-0.10105559,0.031261515,-0.012714104,-0.02405969,-0.013834513,-0.017353712,0.030534916,0.012851285,0.019491512,-0.0005154446,0.06188669,0.043707468,-0.015479014,-0.048783015,-0.024254788,-0.037374273,0.028644929,-0.07199646,-0.0010670683,0.023682805,-0.03489012,-0.017410055,-0.038737036,0.054637708,0.0058768676,0.0027377484,-0.01597357,0.026435422,-0.05611955,0.0150625445,0.0034443757,0.046375647,-0.0043342775,0.03326635,-0.041133106,0.0058931485,-0.06739357,0.014073904,0.04203974,0.07322649,-0.0066929646,-0.0013576262,0.0484412,-0.062581256,0.026088621,-0.06634908,-0.035856575,0.0008346149,-0.014496148,-0.045846596,0.10457239,-0.081230976,-0.04239848,-0.07809239,-0.06480731,0.005357088,-0.06920585,-0.07099087,-0.008914549,0.081613086,-0.029858373,-0.07803214,0.06958455,0.009047177,0.011555501,0.024142666,0.0054661133,0.09845716,0.06585292,0.074504584,-0.06603726,-0.035684444,-0.1069033,0.0072115064,-0.028247144,0.016403569,-0.0064889085,0.025891386,-0.084356695,0.07072043,0.12838222,0.05745826,5.6863686e-05,-0.02004472,0.0045695645,0.08492855,-0.038443737,-0.07565393,-0.1300644,0.01785484,0.049059622,0.10121234,0.017789776,0.025593374,-0.01988729,-0.020155797,0.03587481,-0.08295315,-0.026997877,0.12488409,0.051164094,0.038729437,-0.061623197,0.05706022,0.014380204,0.09520676,0.043085683,0.026182808,-0.006263226,-0.05177715,-0.067530565,2.4655566e-33,0.114515424,0.08207051,0.016461143,0.08315051,-0.08374261,0.018540926,-0.13657443,-0.08004198,-0.076579,-0.07056638,-0.018888842,-0.09544501,0.054749995,-0.06490429,-0.019331435,-0.057020076,0.009059019,-0.036059026,0.017189674,-0.0076706624,0.05112176,0.16914628,-0.009294083,0.055158567,0.029921452,-0.005081296,0.018002013,0.045048345,-0.012394227,0.0024853486,0.02358159,-0.0049640196,-0.11897658,-0.009824704,0.04470477,-0.064635694,-0.06928684,-0.010227507,-0.058626447,0.034182966,-0.010539538,0.03567384,-0.033105604,-0.04163335,0.093932,-0.12806533,-0.00301678,0.08871915,0.052364957,0.116995715,-0.03691709,-0.0065443036,0.08389253,0.020149015,-0.061961632,-0.01594513,-0.022681711,-0.008879813,0.010063746,0.087679796,0.081493296,0.08005212,0.017953087,0.06271264,0.0018746182,0.053860802,-0.07871878,-0.08802336,0.026992457,-0.00305434,0.034704912,0.03558792,0.059151623,0.044236474,0.022036327,-0.016036695,-0.09104834,-0.018857038,-0.011438732,-0.05210631,-0.0111575965,-0.021873523,0.017678576,-0.022020787,-0.034352314,-0.032991227,-0.0073810946,-0.027165392,-0.012600678,-0.008507637,0.023603065,-0.08559685,-0.023240939,-0.084468246,0.044339582,-1.8770994e-33,0.07099086,-0.017361883,0.031898517,-0.07594401,-0.037080277,0.042484485,0.041717414,-0.18210268,-0.042215284,-0.031958506,0.053972255,0.032375496,0.0026190826,-0.036602065,0.046273727,-0.03561485,0.016429638,0.0123110665,0.053523496,-0.0044333963,0.009095823,0.012538704,0.0011595706,0.033331785,-0.001465471,-0.0034173399,-0.051413797,0.004594142,0.093845524,0.013392926,-0.009820716,0.019448971,-0.040385388,0.0056336382,-0.05692844,0.031789627,-0.04953649,0.07132046,-0.009968707,0.034428105,-0.014061697,-0.06730828,-0.017087761,-0.014706424,0.07021041,0.0022390028,-0.018062856,0.042354602,0.007365142,-0.029623013,0.01179181,0.024230553,-0.019142099,-0.010505858,0.07784614,0.0005089061,0.038397413,0.0560027,0.06399719,-0.01563439,-0.018733032,0.003525597,0.07622036,0.024800137,0.022390813,0.038834505,0.026399812,0.06510182,0.068104066,-0.030045653,0.03027718,0.067550845,0.097384185,0.034274425,0.02511439,-0.050790545,0.046019644,0.008280335,-0.018355643,-0.014602518,-0.06448071,-0.054510143,0.015694508,-0.047116134,0.022410002,-0.10695489,0.02558531,-0.035410427,-0.027792502,-0.02939112,-0.021692896,0.017145041,0.006787984,0.039175674,0.034902606,-3.89886e-08,0.035113007,0.010701286,0.0060394476,0.00079447794,0.013064401,0.013106359,0.07954829,-0.044074964,-0.0015051728,0.039661985,0.0348578,0.07353304,0.108223595,-0.041796774,0.071107194,0.040175933,-0.021749536,0.004477781,-0.0033943981,-0.063628785,-0.026329624,-0.050411433,-0.09994521,0.057298217,-0.027757678,-0.07751406,-0.022515656,-0.04455097,0.034178946,-0.0008847518,0.056250367,0.010497553,0.09342849,-0.06208262,-0.016894547,-0.021732287,-0.05963524,0.07853332,-0.030846495,0.043662984,-0.023717104,-0.039220687,-0.054507576,0.014118532,0.022875896,0.0032001087,-0.012714707,0.030287826,-0.0304809,0.008773608,0.04539316,-0.025864465,0.03524314,-0.016092595,-0.09010874,0.0891289,0.027125807,0.005978118,0.041877463,-0.099031776,-0.05284124,0.0064469962,0.0613947,-0.025814898 +1.14.99.4,"Has a wide specificity. A single enzyme from ascomycete the Neonectria radicicola (EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.12 androst-4-ene-3,17-dione monooxygenase.",384,1.0,-0.034414362,0.033663396,-0.09425627,0.013280082,0.07655272,0.032288037,-0.10132822,-0.0003142024,0.056764662,0.021958187,0.005226997,-0.072549045,-0.086180314,-0.047264088,-0.09059126,0.04017177,-0.0109526515,0.013308501,0.051826026,-0.065411605,0.054462444,-0.050830618,0.014845637,-0.023668747,0.04519456,0.007826197,0.018752031,-0.052125685,-0.07654045,-0.11850061,0.012813069,-0.0028163285,0.076838315,-0.0304555,-0.015925776,0.08896082,-0.030923396,-0.08683126,0.08751401,0.03451007,0.0026006165,-0.012766698,-0.047710896,-0.022713896,-0.09018976,-0.058892433,0.00039535787,-0.0123160705,0.09904932,-0.04767376,-0.013300573,-0.054477286,-0.025233839,-0.049240828,-0.01522228,0.0076417685,-0.09194177,-0.018667549,-0.021892125,0.013149928,0.051569093,-0.027325764,-0.049856238,0.07367354,-0.005967289,-0.021981811,0.017469067,-0.04272801,-0.0731906,-0.069468096,-0.03013095,-0.026159374,0.023149874,-0.007600916,-0.026991906,0.062413134,0.007886699,-0.06247559,0.010424171,0.026050005,0.008743556,0.060227714,0.0240302,-0.013384272,0.03184102,0.023762645,0.024390262,0.063624226,0.05937005,0.05346347,0.043362614,-0.007501059,0.06995671,-0.012475698,0.008549785,0.044365495,0.05740308,0.06402352,0.06625887,-0.07295152,0.001211033,0.07605155,0.006249059,-0.02462299,-0.0017065696,0.039360184,-0.011369705,0.03282233,0.073101595,0.0036706042,-0.041898474,-0.12071875,0.08782789,0.0011416832,-0.011154762,0.085708044,0.03533839,-0.09194976,-0.04014536,0.03378244,0.07366439,-0.053480558,0.0016104468,0.05155232,-0.03202998,0.084986076,-0.09372192,2.4178027e-33,0.05271023,0.043140247,0.018678479,0.014259902,0.02478035,0.05362281,-0.0383931,0.029541612,-0.11144018,-0.014400182,-0.070782594,0.0050965566,0.042342264,0.027397301,-0.022231625,0.0042260773,0.00055668823,-0.0059656715,-0.014704111,0.017916042,-0.032900035,0.0036464883,-0.13858241,0.02533322,-0.018236252,0.048637163,-0.021644194,-0.005550253,0.06504185,-0.009465755,-0.019301035,-0.04233752,-0.094656676,0.036095746,-0.029788012,0.008996227,-0.012460144,-0.0420747,-0.04906821,0.03938543,-0.047974497,0.0541904,0.019274035,-0.071215816,0.06862527,-0.073322274,-0.08380052,0.06843311,0.071207665,0.106535345,-0.0022538034,0.04922785,0.0707259,-0.04797092,0.009201354,0.15037054,-0.04545526,0.04966999,0.050426956,0.03727068,-0.017701859,0.028508471,-0.04481234,-0.012223008,0.038224272,0.053363264,-0.035431903,-0.044643585,-0.044607885,0.087585494,-0.040925834,0.0041842805,0.040548354,0.015787864,0.011911685,0.01138465,-0.0073276577,-0.0224631,-0.034171056,-0.010538983,-0.021477016,0.05191582,0.04050947,-0.04871659,0.011438166,0.041781064,-0.023969658,0.005317588,-0.028013036,0.11361871,0.0482985,-0.08314967,-0.13324325,0.0047623166,-0.0026998443,-3.443732e-33,0.117890544,-0.06747159,-0.044898987,-0.12597007,-0.08696541,0.1015625,0.022301808,0.041430254,-0.01802574,-0.028834667,0.09977299,0.008793897,0.050846625,-0.046186112,0.038289174,-0.006943532,0.035127528,0.06842007,-0.02124704,0.022361446,0.009921877,0.09447571,-0.025447007,0.039254326,0.06105236,-0.026911678,-0.01916326,0.07704264,-0.02686686,0.021176796,-0.07769491,0.0068426956,-0.0021113278,0.038850334,0.034999304,0.07023902,-0.07396381,0.010130774,0.041390654,0.036411572,-0.02627727,0.0056265253,-0.0043474114,0.07541801,0.026116546,0.022107055,-0.11714909,0.037294682,0.08586008,-0.11384618,-0.06776318,-0.009980245,-0.046723764,0.018886542,0.0292069,0.033485003,0.015510919,-0.024562836,0.029027669,-0.054265767,0.00019775223,-0.036658965,0.04774949,-0.026167588,0.03486339,0.05716063,-0.11248456,-0.06725913,-0.03703201,0.06744995,0.061728798,0.007360105,-0.03288394,0.0229357,-0.0076295985,-0.07231138,-0.055236664,-0.058164783,-0.02701031,0.008718693,0.028870922,0.027726877,0.016011145,-0.063197464,-0.025355464,-0.09028407,0.06483957,0.050627317,-0.04413567,0.025866687,-0.011869853,0.0031795157,-0.062394828,0.045185518,0.07465601,-3.8646323e-08,0.08320967,-0.00868638,0.07485112,-0.0754114,0.0018388995,0.07730219,0.010487299,-0.04026364,-0.0022600014,-0.027704086,-0.022560095,0.05961606,0.059347373,0.06627549,0.0710956,0.01707552,0.0048136543,-0.018785767,0.006377618,-0.00469727,-0.03421259,0.009055635,-0.017083187,0.03454011,-0.026112175,-0.036111183,0.05723669,0.009347636,0.05519726,-0.013489688,-0.10523714,0.020264931,0.030605989,-0.024080925,-0.052323233,-0.0043971795,-0.08649184,-0.00325149,-0.035165127,-0.043744337,0.038800202,-0.06794115,-0.03991133,0.0021081562,-0.024872813,0.031589806,0.073784776,-0.04747087,8.092085e-05,0.0014590659,0.05389449,-0.05582701,0.0092228055,-0.0009999567,-0.045242023,-0.03070249,-0.016317014,-0.042491842,-0.039892208,-0.038498335,-0.012859103,0.03780255,0.18273303,-0.004596826 +1.14.99.7,"A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase.",384,1.0,-0.07923378,-0.09345083,-0.08145581,0.023427704,0.1083434,0.005491709,-0.05387539,0.07392212,0.04828129,-0.042067867,0.010863246,0.0030379028,-0.064267196,0.012203761,-0.10211797,0.028392052,-0.087333,-0.015737953,-0.029799998,-0.0376287,0.0017702526,0.010978203,0.051110644,-0.017998166,0.022140874,-0.01953383,0.03176603,-0.045809533,-0.032574777,-0.024728265,0.106049895,0.045503605,0.06190735,-0.015996525,-0.065993845,0.042235818,0.046857893,-0.033110734,0.01114004,0.047575023,0.023422465,-0.029634252,0.049119964,-0.032692168,0.06969791,0.0065616486,-0.036052156,0.034454826,0.0057436004,0.022651386,-0.017292906,-0.071843944,-0.099730425,0.015216799,-0.013696356,0.02975232,0.00035447124,-0.07278181,0.017161049,0.02311754,0.026850179,0.017492522,0.051169235,-0.0076180105,0.041217804,-0.026986677,-0.037426613,-0.05433267,0.042125344,-0.024846928,-0.031020049,-0.044453748,-0.060391236,0.06696851,0.020537792,0.051940102,-0.08800007,-0.06520711,0.046981853,-0.0055458345,0.06372353,-0.03617306,0.035694517,0.032128308,0.097428635,-0.03714368,0.058933638,-0.013108898,-0.039187342,0.03419438,-0.008813064,-0.0048139207,-0.016509546,0.018251546,-0.07240862,0.06271666,0.037236936,0.018110242,-0.08913991,-0.028343799,-0.034403194,0.0021557363,0.004875054,-0.046800695,-0.0701862,-0.09454788,0.029693285,0.07492178,-0.019457927,-0.058242,-0.041270882,-0.035687756,0.006184121,-0.05380353,0.012923011,0.046701882,-0.039288186,-0.064619526,-0.0022013339,0.04085756,-0.020977842,0.09901419,0.0256114,0.13343233,0.056461986,0.0027283381,-0.1062456,2.9480827e-33,0.06643375,0.04842859,-0.018102778,-0.01165711,-0.009024832,-0.0012145482,-0.08367736,0.00855942,0.0064721326,-0.05343687,-0.014428252,0.010698314,0.020992218,-0.055543557,0.04401983,-0.032498214,0.0025153828,-0.013584755,0.094930716,-0.1256638,0.00922335,0.037773244,-0.026856327,0.06152151,0.023921186,0.006094015,-0.074072346,0.030244818,0.08027842,0.040768534,-0.033851903,-0.048204843,-0.058061764,-0.01975548,-0.046643976,0.03808954,-0.072940655,-0.11264355,-0.08689571,0.06721234,-0.00092827284,-0.03709181,-0.021141088,0.013431566,0.026624894,-0.025646117,-0.10739735,0.10566546,0.023137307,0.06095011,-0.022316327,-0.042092413,0.11292152,0.06475195,-0.041128147,0.0010295463,-0.07277445,-0.0016713723,0.015666695,0.010272156,0.036102787,0.10115513,-0.026757663,0.077299744,-0.10718148,-0.009513944,0.0325119,-0.09799315,0.0018702232,0.09590203,0.015371851,-0.016049145,0.07610355,0.013705266,0.092897154,-0.05794935,-0.030358413,-0.0372302,-0.024894001,0.0002445709,-0.048234835,-0.027107509,-0.04317305,-0.02368888,-0.020068662,0.0011181858,-0.039644513,0.0017310705,0.016185952,0.0326555,0.038705103,-0.079217345,-0.011268676,0.033917446,0.028749535,-1.8544217e-33,0.0135312695,-0.09292593,0.050077233,0.019752083,0.0171447,0.03710787,0.03439559,-0.027086534,0.039567053,-0.058914393,0.062285475,-0.109551415,0.016323717,-0.04302161,0.041486442,0.030357115,-0.008935994,-0.03643353,0.08151381,0.06667797,-0.028366841,-0.02420768,0.04226511,0.09248664,0.061710227,0.037490226,0.031288862,-0.00834123,0.012094919,0.04582454,-0.064233795,0.055249088,-0.04932578,-0.00985114,-0.09827158,0.04173817,0.0018704159,-0.001559172,-0.03283955,0.020780817,-0.033972457,0.049786173,-0.010280848,0.08136234,0.06603293,0.045772403,0.005913291,0.047791265,0.083391726,-0.07621202,0.019639771,0.047398064,0.01787275,0.028901061,0.03205305,0.048868407,0.018293474,0.081787065,-0.016636113,-0.023456097,0.007399434,-0.105423726,0.013891653,-0.015018848,0.081561364,0.06154207,0.03203855,0.12645438,-0.020372655,0.022056391,0.13332918,0.0077521103,0.018027507,0.07717315,0.015109486,-0.05229544,-0.0144028375,0.055385493,0.0031190272,0.003168057,0.021942297,0.0062829456,0.007627402,-0.007969467,-0.08386332,-0.10445812,0.036328033,0.09974942,0.004176164,0.040321898,-0.04023588,0.03624929,-0.06764572,-0.018871387,0.07937721,-2.9002363e-08,0.018660279,-0.060855277,0.026690567,-0.03340436,0.1312041,0.0040158834,-0.019488184,-0.018115206,0.0010163406,-0.018062338,-0.066978306,0.11433123,0.015480542,-0.024870442,0.061457995,-0.042884283,-0.00069666596,0.057312485,-0.0016926067,0.017068764,-0.02297638,0.045768894,-0.09691523,-0.013925311,-0.07141453,-0.014778439,0.018658292,0.010838065,0.0030866498,-0.03717277,0.016653731,0.028779583,0.026186757,-0.015192778,-0.124966055,0.035390213,0.022601174,-0.04328921,-0.06489241,0.06600939,-0.08467929,-0.023707123,-0.019900493,-0.04702824,0.009573433,-0.015823023,0.053504784,-0.06771932,0.009204742,-0.03238789,0.004299955,-0.034119118,0.028958196,-0.008577631,-0.033226542,-0.008265539,-0.022151861,-0.10056495,-0.048800975,-0.061893545,-0.009397344,0.0144691765,0.15016705,0.031173173 +1.14.99.9,"Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17alpha-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17alpha-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 4.1.2.30, 7alpha-hydroxyprogesterone aldolase). The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones.",384,1.0,-0.011378175,0.017971791,-0.06548434,-0.08308476,0.029435536,0.032356527,-0.10241805,-0.009038529,-0.01478621,0.021351427,-0.0038780023,0.03401659,-0.06990303,-0.020515397,0.040814914,0.05489837,-0.032938283,0.012680736,-0.013720627,-0.043771777,0.0591166,-0.029562436,-0.06598678,-0.043327503,0.08674728,-0.08197424,0.018219603,0.025356848,-0.10525228,0.011625336,0.006517517,-0.00047700846,0.028725747,-0.08053976,-0.032483675,0.05249982,-0.09174943,-0.11590619,0.067017384,0.08087837,0.005777247,-0.060551196,-0.06841027,0.020178337,-0.04658617,-0.030231595,-0.011990785,0.08337536,-0.03914673,0.032114077,-0.013440405,-0.026621748,-0.037990157,0.06487679,0.0039924835,-0.04494849,-0.039898742,-0.014069523,-0.015086661,-0.009269732,-0.07179866,-0.03390545,-0.08430931,-0.02966353,-0.030731814,-0.040117316,0.07064919,-0.05289203,-0.019058552,-0.031405415,0.036962293,0.0058816597,-0.038004294,0.02147139,-0.030809155,0.05426883,-0.056826673,-0.03345141,0.020781098,-0.0070868246,0.024020314,0.024779713,-0.0044759857,0.13310598,0.06983042,-0.010410907,-0.026835695,0.045468576,-0.034616027,0.102964945,0.01255721,-0.05406665,-0.0019495739,0.04241462,-0.010765522,0.054691378,0.014964715,-0.04354426,0.006600373,-0.046550803,-0.019125666,0.07064696,0.028558612,-0.021738146,-0.061319906,0.043038033,0.025675694,0.101049855,-0.02108673,0.009670314,0.027298149,-0.022854993,0.020216122,0.03045183,0.004111099,0.07316682,0.06329776,0.0043590106,-0.0825892,-0.07219626,0.02804721,0.023312964,0.075528644,0.051963665,-0.005627952,-0.028946843,-0.06900615,4.4647524e-33,0.118521355,0.007708789,0.023072094,0.04730367,-0.047159325,0.1437925,-0.059631024,0.03829001,0.026813658,-0.07200208,-0.036174383,-0.049317855,0.04392403,-0.055807967,-0.018117016,-0.04805675,0.047492724,-0.056660663,0.09013463,0.020917589,-0.0120536415,0.07446229,-0.10549626,-0.012570894,-0.0075185117,0.03624414,-0.047993883,0.055865303,-0.060573738,0.017141793,-0.07267998,-0.071314886,-0.0027513986,-0.011465252,0.028507207,-0.040311,-0.06006201,-0.053614404,0.03239057,0.030972883,-0.0021885666,0.024866542,-0.0001983467,-0.08607651,0.053984176,-0.007393467,-0.014929501,0.0041864356,0.049109753,0.06992252,0.0007241473,0.044534992,0.0903902,0.010690325,-0.07129222,0.07718061,-0.05576366,-0.0598547,-0.004769402,0.10303835,0.01320123,0.05521909,0.04025277,0.014109034,-0.04702207,0.0029722387,-0.026755147,-0.10862906,-0.06630565,0.083255865,-0.0016395232,-0.0073167617,0.09795272,-0.012600547,0.04592144,0.03952498,0.04038989,0.051081773,-0.0123962145,-0.06291249,0.003013985,0.064388104,-0.046887644,0.009491151,-0.0119179655,0.055359818,0.017656941,-0.042455044,0.04034735,0.08340156,0.03582228,-0.09996843,-0.008975304,-0.01677879,0.052494675,-5.4802116e-33,0.1074536,-0.14839996,0.03048747,-0.12065986,0.009660148,0.08206435,0.10902164,-0.08119857,-0.004073517,-0.015414544,0.040120773,-0.03679136,-0.07638349,-0.06134454,0.05888051,0.004751919,-0.07641859,0.07286937,-0.037418563,-0.0108504575,0.01848672,0.09844905,0.041370742,0.077581465,0.07255091,-0.07116238,0.013787058,-0.042476933,0.061457105,0.0933135,-0.046055574,-0.040692993,-0.053001583,-0.024164638,0.020602314,0.08758419,-0.097520515,0.09506752,0.061667655,0.026588963,-0.027759643,-0.011085197,0.01911417,-0.038313415,0.03778166,0.03212369,-0.037978895,0.032694966,0.014864937,0.008251598,0.0035869933,0.0039938833,-0.10481977,-0.014058029,0.005098799,0.020090133,0.043602493,0.01800738,0.054898415,-0.023100205,-0.009695655,-0.051388584,-0.045807444,-0.023535343,-0.018187476,0.005946363,0.02607212,0.018237986,0.0529286,0.05363387,0.047572933,-0.023128686,0.06823004,0.06925855,0.031264175,-0.11119222,-0.05108274,-0.06364212,-0.015160311,0.014216386,0.03872808,0.0109676635,-0.03153092,-0.012158306,-0.07859133,-0.050845526,0.034158144,0.04124827,-0.052558385,0.038353484,-0.04687946,0.012686431,-0.07474731,0.01418731,0.002238537,-4.4662084e-08,0.0114221135,-0.02620104,-0.0010605316,-0.007760875,-0.033170905,-0.020711549,0.014646204,-0.00083141436,0.09243359,-0.02617092,0.042734604,0.11291357,0.025696011,0.005706836,-0.019044418,-0.039727006,-0.027596992,0.021978453,-0.00940257,-0.032881383,0.01074148,0.010552473,-0.12750673,0.030862784,-0.032630045,-0.053920545,-0.0040741195,0.02150657,0.07988522,-0.046009574,0.08192486,-0.052516814,0.0544698,-0.052487057,-0.007681064,0.028297853,-0.04284251,0.014533248,0.09015442,0.012084566,-0.048521925,-0.1134271,-0.001770414,0.07663849,0.015933126,-0.0075322334,0.025618615,0.01956802,-0.018615516,0.04601886,0.017536951,0.010985046,0.04776387,-0.04367707,-0.002442336,0.0035337447,-0.012880781,-0.09069556,0.016925823,-0.05053249,0.006753949,0.013356913,0.11504333,-0.035966713 +1.14.99.10,"Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A heme-thiolate protein (P-450) enzyme responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol.",384,0.99999994,-0.05034132,0.040644582,-0.06785701,-0.048123535,0.03162888,0.036759473,-0.06496242,0.052264452,0.007287978,0.014904344,0.0015173971,0.0070073465,-0.07246868,-0.025662629,0.011676827,0.024300342,-0.040892277,-0.014539025,0.04901864,-0.07315827,0.0019172587,0.005331035,-0.045603495,-0.025199918,0.041834746,-0.02600365,0.031253077,0.076670215,-0.09299371,0.010029851,-0.026705684,-0.03700307,-0.0054604295,-0.030647285,0.024778757,0.11741587,-0.11701743,-0.056461412,0.026242953,0.028776657,0.07789305,-0.058291517,-0.12231122,0.029758705,-0.0071563898,-0.029828057,0.0012681443,0.086547166,-0.019511634,0.05548742,-0.015489723,-0.042894583,-0.04213734,0.06964879,-0.020677581,-0.053531323,0.0191212,-0.030827448,-0.012184238,-0.040214337,-0.079332754,0.014506576,-0.05328026,0.0032593014,0.03424181,-0.05261918,0.044890206,-0.012646237,-0.07764153,-0.081319064,-0.007975261,-0.010461398,-0.020787656,0.037987936,-0.03770738,0.06991716,-0.06160817,-0.033298027,0.027574088,-0.009814099,0.05207068,0.023465965,0.017602172,0.11412809,0.086290434,-0.01405308,-0.021822713,0.008533178,-0.039806765,-0.005438884,-0.050768666,-0.09761263,-0.032290462,0.06326519,-0.09043282,0.06582836,-0.056911178,-0.005233855,-0.036554694,-0.02757402,-0.033989195,0.08879086,-0.015852718,-0.0756336,-0.09889123,0.04850712,-0.0028836643,0.070233375,0.021250717,-0.0128475595,-0.03089404,-0.052253395,-0.012270031,-0.008775906,0.055289626,0.09384223,-0.03053311,0.03754777,-0.017403705,-0.13235177,0.00029809872,0.004444835,0.057371847,0.0065311384,-0.017885841,-0.02255747,-0.07167373,2.8295227e-33,0.13610059,0.02074153,0.03569268,0.050744366,-0.032245222,0.14464042,-0.08753424,0.06629448,0.019235771,-0.09090457,-0.039421897,-0.09644957,0.053213026,-0.086644374,0.012037385,-0.07154075,-0.004662769,0.016069615,0.0855535,0.023585293,-0.03949743,0.06968736,-0.08528764,0.023326408,-0.014419688,0.09137889,-0.028849028,0.07667018,0.006519544,-0.0029676445,-0.049486116,-0.09831113,0.01613628,0.0018072604,0.0069374344,-0.04617535,-0.059452754,-0.028591417,-0.0056126635,0.047400944,-0.018317487,-0.03559737,0.009334606,-0.08917293,0.05343836,-0.045841083,-0.014477597,0.025915263,0.057607993,0.030190477,-0.005530674,0.0057572974,0.13172266,-0.00017723348,-0.0846617,0.05926262,-0.036188096,-0.028529372,0.0022582868,0.06597163,0.07286744,0.0135349445,0.027036417,0.023809474,-0.00082347565,0.058342334,-0.03230201,-0.06465934,-0.020226927,0.16293569,-0.051413275,0.07052393,0.067281805,-0.0185225,0.023983669,0.024490373,0.028806597,0.057024896,0.019455925,-0.0782102,0.008612614,0.037549973,-0.03985348,0.05072991,0.013694584,0.018924747,0.00091951544,-0.0049704765,0.045216944,0.055163495,0.061500933,-0.07070751,-0.032405436,-0.006859895,0.03747027,-3.8069156e-33,0.061994154,-0.07326082,0.017125666,-0.08988604,-0.012415737,0.07333147,0.078019425,-0.046020124,-0.011184993,0.012257672,0.05779267,-0.04247522,-0.031426776,-0.0651434,0.03785214,-0.01069982,-0.0800683,0.010108408,-0.028409354,-0.018088816,0.02800213,0.12357369,0.03770641,0.019356698,0.07852645,-0.03768255,0.009354498,-0.011487791,0.09182906,0.07269082,-0.070631094,-0.0011369429,-0.06394379,-0.02164559,-0.028264135,0.09914378,-0.0610052,0.05933199,0.0122644985,0.026770556,-0.03950917,0.013897729,0.0016347087,0.02202674,0.035080425,0.10402024,-0.03783437,0.012813282,0.0288135,0.0045410073,0.009806575,-0.007329846,-0.08291934,0.0016760186,-0.00770984,-0.010183436,-0.000671692,0.0057345913,0.03288303,-0.0761893,-0.026980525,-0.015517479,0.0061263056,0.00991195,-0.006248834,0.00993132,-0.03859358,0.008794399,0.020575246,0.066410415,0.07148313,0.0021286176,0.04911449,0.09394921,0.026419397,-0.0972907,-0.021865064,-3.329827e-05,-0.007978098,0.018426975,0.008192141,-0.0074766194,-0.03093264,-0.03935064,-0.07053652,-0.04747167,-0.00085836626,0.07155015,-0.015141276,0.05472662,-0.04097592,0.06572362,-0.048759107,0.068518735,-0.039709266,-4.034254e-08,-0.0046456167,-0.029353678,0.032765605,-0.049601935,0.012380114,-0.01487018,0.05957375,-0.018934213,0.083295815,-0.022601902,0.014109468,0.09208417,0.03473262,-0.019405572,-0.028815622,-0.02676518,0.008060153,0.078091905,0.000383782,-0.016447682,0.008005959,-0.010778533,-0.105705984,0.042202007,0.020452715,-0.05155955,-0.024615249,-0.0150721865,0.03996798,-0.055677623,0.0345353,-0.004311029,0.06905232,-0.08975424,-0.0025596507,0.07117374,-0.055943847,0.06271376,0.024859075,0.0055206576,-0.034535646,-0.09703757,-0.01946035,0.04108914,0.019808592,0.0066889366,0.03982769,0.022753527,-0.01224071,0.0064516347,-0.072651766,0.009958472,0.025333934,-0.07982053,-0.056461953,0.01564511,-0.0025241533,-0.10782497,-0.016889451,-0.06250095,0.01740596,0.010961741,0.17366008,0.0027485713 +1.14.99.12,"Has a wide specificity. A single enzyme from the ascomycete Neonectria radicicola (EC 1.14.13.54, ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.4, progesterone monooxygenase.",384,1.0,-0.03962178,0.011739253,-0.12235934,0.006328596,0.035344694,0.02887614,-0.09409054,0.020300822,0.027248234,0.03193044,0.02949115,-0.07705522,-0.07195268,-0.064575665,-0.051966026,0.07265334,0.0035705331,-0.014675847,0.06741064,-0.043682378,0.059145916,-0.046174467,0.018073762,-0.05234592,0.052142616,0.009678849,0.04568839,-0.011121016,-0.08455892,-0.105730824,0.008642857,-0.007871413,0.049731005,-0.04222303,0.017116446,0.09609683,-0.09521028,-0.06787078,0.08768614,0.03338177,0.02153456,-0.02665857,-0.057538643,-0.03598215,-0.06218063,-0.045874998,0.033267308,0.024491236,0.07475702,-0.017744241,0.01698585,-0.08539929,-0.03301571,0.006165951,-0.03858537,0.0009155072,-0.092228115,-0.041610755,-0.022329595,0.031009672,0.0014817807,0.015634693,-0.05337639,0.034475364,0.029317847,-0.042644702,-0.0021924556,-0.020642215,-0.060874082,-0.06962213,-0.039423354,-0.011591465,0.056139603,0.02947367,-0.011107606,0.025695551,0.0066880593,-0.059461404,0.034726195,0.0031107124,-0.026090182,0.023841795,0.021958955,0.009720789,0.062240075,0.014322028,0.05395595,0.05037934,0.048031133,0.020805731,0.0038988064,-0.016662974,0.04431695,-0.00028265212,-0.026982479,0.05660427,-0.0045698993,0.057354543,0.043141555,-0.057409264,0.002350989,0.064422525,0.0014763672,-0.045213543,-0.056603365,0.061909493,-0.025134265,0.046735924,0.05820175,0.0039655385,-0.041729048,-0.12576132,0.028805075,0.012247338,0.013159188,0.039753307,0.03131864,-0.07676727,-0.013724411,-0.010609337,0.049729384,-0.022908494,0.0045694555,0.041396014,0.005318418,0.09172921,-0.0597752,2.125923e-33,0.051523436,0.022621956,0.038592704,-0.0073065017,0.03647166,0.11078924,-0.04089872,0.03395353,-0.054359734,-0.058033753,-0.08177434,0.0018622283,0.048147347,-0.012355313,-0.010117544,-0.01564082,0.021218352,-0.010435938,0.02554577,0.043487642,-0.04304584,0.023499057,-0.10961409,9.7927084e-05,-0.018551378,0.05929799,-0.029626032,0.02705072,0.026161596,0.001832072,-0.025888372,-0.07043177,-0.054711755,0.05286491,-0.033716828,0.024305224,-0.02683762,-0.02456532,-0.057138056,0.05229908,-0.09534434,0.013917335,0.01833613,-0.06790706,0.020747498,-0.0900071,-0.056910653,0.059530947,0.09811441,0.08178642,0.0040537827,-0.0017397654,0.093176864,-0.04312123,-0.023421612,0.14522442,-0.05610018,0.04042491,0.036302432,0.05191822,-0.029300492,0.04308483,-0.044914998,-0.018878251,0.009939134,0.080928154,-0.03015457,-0.03527671,-0.043455295,0.11235073,-0.07747378,0.03313811,0.06865268,-0.009728331,-0.009331198,0.040541355,0.0015021191,0.00080527406,-0.035319783,-0.024402961,-0.017788893,0.041751884,0.036675576,0.020242928,-0.012134131,0.031215584,-0.0359359,0.0050474093,-0.002947925,0.10692659,0.0424411,-0.06676435,-0.11219501,0.017267395,0.023747947,-3.8212805e-33,0.10904153,-0.086649306,-0.00870153,-0.11630878,-0.057555806,0.12225089,0.029663518,-0.0035476214,-0.04325253,-0.011494428,0.073697396,0.011543958,0.052132443,-0.03240964,0.021126024,-0.027057236,0.012616446,0.105357535,0.0066245887,-0.002664208,0.01306436,0.14981711,-0.038843658,0.029954713,0.09665489,-0.06224951,-0.007701223,0.06787332,0.0018409436,0.040172484,-0.08704722,-0.007116364,-0.006161401,-0.03875925,0.04727697,0.06656158,-0.08689357,0.0101921735,0.051845893,0.03242306,-0.04401298,0.010566922,-0.018074332,0.07581373,0.019578477,0.050421353,-0.07725612,0.040873174,0.07526557,-0.0814054,-0.060251538,-0.008338042,-0.06519893,-0.00027049799,0.02106732,0.024659393,0.018624885,-0.06187382,0.06947276,-0.047907833,-0.053241983,-0.04628361,0.026293876,-0.04148893,0.029643405,0.026790788,-0.095641136,-0.053138375,-0.037158046,0.08059814,0.11850405,0.022357734,-0.026918398,0.03809762,0.001413998,-0.065217964,-0.06407531,-0.05990338,-0.04406469,0.03762735,0.052049108,-0.021099342,0.026280167,-0.06242624,-0.05397485,-0.056337822,0.059278965,0.05845366,-0.05286693,0.022854725,-0.020704398,0.008439676,-0.054288313,0.045096863,0.025038974,-3.789943e-08,0.059090097,0.016321132,0.08731371,-0.0925095,0.041335464,0.05947411,0.018485406,-0.046416916,0.028735515,-0.031093173,-0.050420865,0.08865774,0.080025084,0.040399924,0.014963186,0.037778206,0.02099338,0.0005254205,-0.00495295,0.0153500065,-0.028645638,-0.011546438,-0.065565735,0.013464321,-0.02135021,-0.038648173,0.06460846,0.01810148,0.017036708,-0.040465306,-0.073558815,0.026970431,0.05061446,-0.04432067,-0.06853098,0.023424312,-0.025304269,0.02624013,-0.038165655,-0.034455597,0.034752455,-0.09347226,-0.011886087,-0.0018223388,-0.03855804,0.04617527,0.09499127,-0.06341225,-0.023597026,0.004925151,-0.0008770433,-0.05628589,-0.020805422,-0.0020898527,-0.021521525,-0.03964411,-0.01990771,-0.09098461,-0.04997901,-0.009105221,0.017632006,0.035485566,0.20171325,0.015184045 +1.14.99.15,"The bacterial enzyme consists of a ferredoxin-type protein and an iron-sulfur flavoprotein (FMN). Also acts on 4-ethoxybenzoate, N-methyl-4-aminobenzoate and toluate. The fungal enzyme acts best on veratrate.",384,0.99999994,-0.018007837,-0.034388825,-0.13724716,0.039915767,0.09105819,0.04019606,-0.036322284,0.015660243,0.012577254,-0.08904859,0.014479665,0.005868057,-0.08413933,0.10772751,-0.08116775,-0.0105819,-0.04654339,0.02915779,0.0044947034,-0.01615068,0.008687533,0.042111464,-0.0033931008,-0.058376886,-0.029707607,-0.018180685,0.04187155,-0.013546531,-0.054263607,-0.07858473,0.028236095,0.035307616,0.05588404,-0.037852872,0.04200948,0.05358744,0.031786874,-0.06503013,0.07558661,-0.018554902,-0.0018119588,-0.008801292,0.060882125,-0.080137715,0.01559841,0.020160105,0.050770815,0.031150712,0.097845025,0.0057644243,-0.09035248,0.0037947993,-0.032410994,0.11953215,-0.0018546385,-0.021816643,0.02654102,-0.036658324,-0.0552027,0.0057855677,0.0044716615,0.010691204,0.024112377,0.017544586,-0.009159613,-0.05083955,-0.019406367,-0.043071646,-0.025769394,-0.051501315,-0.020914726,-0.033053346,-0.029480398,0.033013932,0.015333096,0.06421448,0.020941216,-0.020768415,0.01169745,0.0106046805,0.0047449567,0.04145756,0.04574626,0.08673948,-0.0009291017,-0.03617176,-0.038965482,0.027885381,0.0025630414,0.12131355,0.04616471,0.08368215,-0.00041970218,-0.058825452,-0.054207332,0.032078262,0.00983981,0.06873041,0.048292268,-0.008378376,-0.06023958,-0.042985164,-0.001467899,-0.05909312,-0.034222774,-0.018186366,0.039492525,0.0980142,0.06738949,-0.048328396,-0.006673456,0.025126072,0.068466574,-0.08275799,-0.005763683,0.017191451,0.059506036,-0.029002637,-0.080548756,0.013296531,0.029494422,0.0056763077,0.051067803,0.084432654,-0.013657303,0.043330275,-0.12425171,1.9861509e-33,0.0843089,0.054815117,-0.012129164,-0.035619665,-0.01144817,-0.043003418,-0.0038809786,-0.0024160636,-0.042292103,0.0049408292,-0.10906856,-0.03500975,0.038861264,-0.02024588,-0.020435004,-0.033519607,-0.03733263,-0.061986648,-0.0028887857,0.02287986,0.13840611,0.06974901,-0.0040312307,0.027785268,0.08067735,0.052409843,0.026432863,0.028809808,-0.029991532,-0.02345345,0.019654535,-0.12693155,-0.0613645,0.0021945979,0.12498552,-0.0016387358,-0.023416443,0.013121678,-0.054642744,0.023903344,0.021316351,0.052791253,-0.04891045,-0.021078596,0.095661975,-0.018731954,-0.08625024,0.11593565,0.054460052,0.07793516,0.075225495,-0.048238534,0.11187576,0.00394687,-0.030671742,0.039443303,-0.012810112,0.02191595,0.019517718,0.013048458,-0.014410576,-0.019254018,-0.03687434,0.005424913,0.016080119,0.027034843,0.016746694,-0.024511687,0.029160315,0.027044643,-0.043217517,0.06674521,0.038344543,0.04969725,0.00046693953,-0.068617515,-0.13001657,-0.10110809,0.056218512,0.019518439,-0.019177718,-0.06011691,-0.0114593515,-0.035610743,-0.101812124,0.0147816315,-0.041576073,-0.0011126254,-0.04295925,-0.042683747,0.094557606,-0.07508541,-0.015659412,0.011199721,0.022845302,-2.1308877e-33,0.06558847,-0.08898169,0.007978417,-0.01218251,-0.08929562,0.04138741,-0.03220644,-0.006779796,-0.02348413,0.054344043,0.023459693,-0.08241124,0.0113980025,-0.020625751,-0.04085475,0.05017541,-0.026630934,0.026984882,0.029735135,0.0151865445,-0.0768639,0.030426592,0.0238742,0.0141436495,0.025913918,0.032252107,0.011635118,0.08950305,0.05632894,0.037252672,-0.034688823,0.034188006,-0.0054945108,-0.11011529,-0.010879769,0.061435986,-0.04036531,-0.023635225,0.050612528,-0.019947104,0.08086715,-0.00048802336,-0.032757796,0.08374035,-0.019208476,0.10303183,-0.121702805,0.07378182,0.012868929,-0.010176026,-0.011732192,-0.037850056,-0.014352094,0.026650267,0.018068885,0.0012050536,0.07107436,0.045455016,-0.040402565,0.024844635,-0.01959509,-0.12165365,0.04888712,0.05355439,0.037321787,0.09650967,0.016670493,0.054974668,0.016374137,0.005920314,0.056410052,0.00012557201,0.072456665,0.05409327,-0.013658826,-0.019120343,-0.0028683597,0.032633405,0.010625137,0.030079216,0.041524325,-0.031804178,0.0033711179,-0.07883131,0.0017770057,-0.032200877,0.013714224,0.08183565,-0.030668385,0.028615505,-0.0075491513,0.0355545,0.0056938445,-0.048564095,-0.012137974,-3.6051432e-08,0.015527895,-0.09319246,0.042095568,-0.068061695,0.0059457463,0.02849843,0.053129714,0.00337516,-0.015754875,-0.01955742,-0.026374865,0.10583553,-0.037527267,-0.033178717,0.062200554,-0.024508253,-0.019241774,0.008712536,-0.035749882,-0.0059340647,-0.04504233,0.008263057,-0.13142467,0.04573838,-0.0053217914,-0.056609094,-0.017672746,0.011578714,0.07489713,-0.023327334,-0.048302803,0.04076598,-0.01960901,-0.05569533,-0.17673881,0.019299185,-0.078712195,-0.07934489,-0.011642602,0.030052528,0.0032828837,0.008969307,-0.09819584,-0.08800936,-0.027751032,-0.028311176,-0.00037707482,0.01651954,-0.020535344,-0.035497457,0.07389869,-0.048343074,-0.022512423,-0.023582458,-0.116173185,0.060459938,0.07046478,-0.025089111,0.026023606,-0.029623741,-0.07710877,-0.020885024,0.10282494,-0.010424518 +1.14.99.19,Requires NADPH or NADH. May involve cytochrome b5. Requires Mg2+ and ATP.,384,1.0,-0.0564328,-0.013813989,-0.036027454,0.0044073565,-0.016706355,0.012588275,-0.013302227,0.026978808,0.009293474,0.04658238,-0.0030829904,-0.038449667,-0.04239009,0.10693203,0.00597421,0.018311936,0.0071205646,0.010697742,0.010316985,-0.0072003114,0.085447304,0.02414985,0.03359256,-0.011440749,-0.006048132,0.009034385,-0.032219235,0.02673379,0.029130349,-0.021417705,-0.07673678,0.050990857,-0.028901799,-0.0317118,-0.028311243,0.10409985,-0.06177392,0.016436704,-0.03265181,0.0043463586,0.034065977,-0.05127055,-0.039405905,0.039188404,0.034820355,-0.06612198,-0.0077471463,0.0360061,0.03495461,0.03161497,-0.05599352,-0.03013579,-0.05316435,0.056656428,0.03679737,-0.02710696,-0.08136736,-0.016163258,-0.033680275,-0.018957188,-0.09668235,-0.039034117,-0.07670588,0.02152018,0.074515425,-0.010627508,0.015617141,-0.03827087,0.0052137403,-0.01899396,-0.051874235,-0.054798964,-0.003806296,0.048454113,-0.092524864,0.033795565,-0.021724325,-0.095811985,0.05581645,0.010939752,-0.05690764,0.050481908,-0.010085112,0.12760565,0.121099666,0.057894923,-0.0028261414,0.042429682,-0.12811421,0.055505194,0.017197572,-0.027868321,-0.008606535,-0.001163642,-0.046877142,0.017420085,0.034021135,0.0027129853,-0.063023664,-0.029304333,0.012982212,0.06245918,0.028392006,0.018763108,-0.07634761,0.011275664,-0.011929382,0.03442903,-0.012900455,-0.016073225,0.03615007,-0.0023888801,0.0035853467,-0.01062871,-0.013880522,0.077061646,0.008656487,-0.043084785,-0.025686309,0.03282386,-0.046719123,-0.0395402,0.017948862,-0.031289477,-0.031385735,0.011778698,-0.015296268,1.6192047e-33,0.08787645,0.05745664,0.05478524,0.10485682,-0.04066215,0.08471433,-0.09721378,-0.009743954,0.0019074047,-0.038536474,-0.037477676,-0.06872839,-0.0041874005,-0.004872299,0.06875406,0.018137908,-0.028299283,-0.025300294,0.07291917,-0.028957594,0.025354883,0.029574705,-0.027820984,-0.054060817,-0.009645624,0.082780555,-0.0020027962,-0.009526558,-0.0048016235,0.0069455933,0.018108843,-0.079390444,-0.061377786,-0.015053156,0.033233386,0.014517144,-0.04282978,-0.045193303,-0.006428382,0.025407057,-0.026763335,0.021629328,-0.010814598,-0.019455623,0.107282616,-0.12780862,-0.061769348,0.058654245,-0.012673001,0.12131851,0.07448485,-0.038686864,0.10628662,-0.032328688,-0.05649158,0.024967259,-0.021215143,-0.018761704,-0.028179409,0.12503824,0.05001292,0.021531973,-0.020070517,0.11795994,0.019048274,0.043278668,-0.1506695,-0.07114097,-0.076882794,0.04694995,-0.030254979,-0.03114495,0.113882266,0.0069493367,0.034265704,0.0068663,-0.0018203371,0.043217704,0.035167135,0.043679032,0.013478515,-0.101537965,-0.024413629,0.019377995,-0.0753279,0.026905894,0.054807935,-0.045513432,0.004269193,-0.0066988277,0.060758118,-0.11456683,-0.03420058,-0.04854394,0.014209671,-3.500723e-33,0.06714913,-0.050931875,0.094863005,-0.086489744,0.031097459,0.10333753,0.072269425,-0.20072886,0.04728693,-0.018581161,0.008592528,0.02177165,-0.05200094,-0.026378917,-0.036923893,-0.002596499,-0.04934917,0.028204797,0.005384652,0.017558957,-0.020466553,0.12972486,0.039665896,0.015780205,0.07920757,0.010615893,-0.02373472,0.00830573,0.025794346,0.04144831,-0.013468568,0.026965251,-0.06489881,-0.08177717,-0.02155309,0.041888222,-0.011494365,-0.011209375,-0.0512184,0.042387675,-0.018438516,0.06314469,0.011564438,0.07182519,0.029789627,0.042208,-0.040860537,0.0074073793,0.042168774,-0.01860577,0.047141306,0.0010372542,-0.10731569,-0.018031396,0.034856327,0.00013014615,-0.07094067,0.009188961,0.03353116,-0.027104871,-0.009433062,-0.04916324,-0.0030595677,-0.025383664,-0.0007286278,0.0028370803,-0.021680024,0.044284724,0.031907696,0.0054240627,0.028041374,0.09275512,0.108397014,-0.010969579,-0.003184314,0.020702923,-0.05700877,-0.015116921,0.005247699,-0.080466956,-0.049332924,0.008153777,-0.10673011,-0.00846545,-0.0018390877,-0.06361224,0.028103547,-0.07676836,-0.009950941,-0.034905747,-0.017638665,0.01277768,-0.041079033,0.067008846,0.0054172957,-2.4773804e-08,0.06794159,-0.006479634,0.06408884,-0.06011545,0.0042657508,0.06917129,0.03737317,-0.049808968,0.07555637,-0.009842417,0.03699715,0.09821677,0.07189049,0.015528087,0.063135445,-0.014210231,0.011986992,0.026768878,-0.05455076,-0.05045959,-0.087564364,-0.07964078,-0.058179293,0.09924878,0.02514295,-0.08688971,0.02933307,0.008679382,0.07557897,-0.03245963,0.07659147,-0.028687445,0.038591344,-0.038853794,-0.030388458,0.06495459,-0.021700278,0.020754432,-0.02823501,-0.010899543,-0.06388247,-0.071124025,-0.044485506,0.05187486,-0.0068585565,-0.044298448,0.00097169454,-0.025845855,-0.031937737,-0.0037454206,0.033746243,-0.0401869,-0.0047432827,-0.07506114,-0.08583253,0.042038664,0.037361722,-0.055991,0.0058024568,-0.12506986,0.06834497,0.06672831,0.099620804,-0.0379283 +1.14.99.21,"A flavoprotein. Latia is a bioluminescent mollusc. The reaction possibly involves two enzymes, an oxygenase followed by a monooxygenase for the actual light-emitting step.",384,0.99999994,-0.010051054,-0.108645245,-0.087276354,-0.008784661,0.04196471,0.020943092,0.0019994401,0.028894857,0.056629244,-0.016051756,0.09890675,-0.059693158,-0.08035559,-0.0063823448,-0.050408415,0.04391089,-0.008050822,-0.01225789,-0.055380836,-0.0021856758,0.046211533,0.013717909,0.016491747,0.024254812,-0.028901476,-0.017338153,0.0069891047,-0.08213656,-0.039454665,-0.07746094,0.09962132,0.080167316,0.05213953,-0.020539105,-0.042888872,-0.0006983407,-0.011593875,-0.100857176,0.01628297,0.047979098,0.008126009,-0.07390629,0.008235049,-0.03021687,-0.014900209,-0.053344652,-0.05146389,0.033980154,-0.043160208,0.004060284,-0.005507728,-0.10829233,-0.12886986,0.04385348,-0.04504681,0.001035384,-0.04695466,-0.045210283,0.0683893,-0.008615315,-0.014560482,0.05569838,0.084128596,0.027037561,-0.01300771,-0.09312714,0.035319448,-0.08125152,-0.007156473,-0.013960469,0.02777414,-0.020560248,0.009997091,0.02718011,0.03569139,0.019950636,-0.023383211,-0.021309694,-0.008104779,0.040158782,0.06282816,-0.051971775,-0.038702995,0.11761223,0.02430019,0.008958656,-0.028697774,0.042896397,-0.015884815,-0.02264558,-0.043958675,0.029334934,-0.02173011,-0.004038438,-0.025054775,0.012224022,0.054723017,-0.060639087,0.0014705966,-0.058437977,-0.06911769,-0.0023764563,0.019340122,-0.0128779905,-0.03156847,-0.052162766,-0.007860314,0.0659006,0.020555735,-0.06823371,0.0035511176,-0.022660885,0.0194845,-0.042749003,-0.014303958,0.08981355,0.037852935,0.00074644043,-0.06027891,-0.051991057,0.04536474,0.06378974,0.013568714,0.042712275,0.047482863,-0.056115415,-0.123476036,4.146856e-34,0.124462776,-0.018799728,-0.034814622,0.0036020328,-0.0205446,-0.015353026,0.007986861,-0.035420887,-0.04836188,-0.09888436,-0.073688164,0.03202902,0.02058787,0.06679103,0.074469514,0.0002162125,0.019446079,-0.017141733,0.04098501,-0.03310656,0.035495352,0.022584682,-0.005848782,0.06294334,-0.019249128,0.03947478,0.020090174,-0.005416583,-0.00302553,0.028381506,0.0029504972,-0.005558469,-0.01147373,0.06674656,0.11685785,0.062365096,-0.040606298,-0.061392475,-0.060940456,0.037677854,-0.04246056,0.026742373,-0.004708417,-0.04694941,-0.0003688917,0.029579313,-0.06387274,0.13059318,0.053476423,0.032388724,0.026995922,0.01643747,0.1120045,0.051019464,-0.0514543,0.09384957,-0.019429358,0.017986925,-0.048370983,-0.03474928,-0.011767961,0.07228802,0.019960353,0.07456999,-0.039870154,0.023661923,-0.058042325,-0.05054833,0.04947002,0.008069402,-0.023025744,0.043756522,0.09766573,0.038004223,0.066440895,0.01016575,0.017985404,-0.04052702,-0.06020768,0.021400353,-0.048981868,-0.044509895,-0.010982081,-0.013771349,-0.043388862,-0.0017583743,-0.00661672,0.05333434,-0.054930244,-0.007909196,0.013650244,-0.065227136,-0.016209787,-0.044537306,-0.014289984,-2.6422714e-34,0.037463076,-0.1274243,0.008178265,0.078962795,0.037133597,0.003438117,0.0132711455,-0.012032376,0.007678873,0.040498585,-0.016672995,0.0093206735,-0.06955514,-0.08013248,0.038981937,0.01786259,0.036283754,0.01925691,0.007405364,-0.025403475,-0.08813617,-0.011655255,0.040774103,-0.045992818,0.04495646,0.06854948,0.058396097,-0.008825715,-0.078850396,-0.034789614,-0.058328167,0.008927541,-0.022920115,-0.055404823,-0.023300856,0.13602875,0.030515179,-0.06788202,0.02894734,-0.012713798,-0.020955872,-0.0077409693,0.046850413,0.03911235,0.056516964,0.024986567,0.018348355,0.025597023,0.00083666254,0.006484445,0.009828659,0.08489158,-0.023407679,0.051017825,0.07353234,-0.02128513,0.029536447,0.024219897,-0.014968524,-0.05865802,0.033514377,-0.06675107,0.0002804729,0.04879146,0.037964817,0.073674776,0.08005288,0.056213725,0.023037454,0.0048982883,0.18028702,0.03718705,0.033208758,0.06440613,0.051362455,-0.103151605,-0.12965539,-0.029399402,0.0044659795,0.040566612,0.013627727,-0.0928358,0.092942186,0.012859954,0.10620302,-0.12797463,-0.080097176,0.09772079,0.032261398,-0.035010096,0.010777671,0.00044448397,-0.05775849,-0.045417055,0.08744245,-3.1026712e-08,0.05171951,-0.009662538,-0.027919142,-0.0058145314,0.078699216,0.015581779,0.0012304658,0.016746042,0.016441481,-0.04925133,-0.052526616,0.07966364,0.01616111,-0.03331757,0.08186935,-0.0281779,0.026322376,0.0066469656,-0.0404327,0.0023848356,-0.074039124,0.0074371044,-0.048633557,0.007283376,-0.077067584,0.0008758909,0.010349742,0.019534934,0.089777894,-0.0715545,0.05084005,0.048736427,0.021364354,-0.08310808,-0.1389977,0.011021586,0.039949883,-0.013278499,0.021115579,0.060610086,-0.10556523,0.007323133,-0.029843638,0.016530344,0.01747305,0.047021475,0.015000624,-0.016469782,-0.018936466,0.039875586,-0.0052152937,-0.027674368,-0.033924185,0.04268347,-0.116042204,-0.05193935,0.01961187,0.010621119,-0.00016182539,-0.07754887,-0.036580995,0.06155899,0.13554475,0.013436283 +1.14.99.22,An enzyme from insect fat body or malpighian tubules involving a heme-thiolate protein (P-450). NADPH can act as ultimate hydrogen donor.,384,1.0,-0.06475616,0.041269135,-0.02664018,0.003137975,0.021724217,0.056697715,0.026029347,0.081414714,-0.008193167,-0.0076834657,0.010876664,-0.047034398,-0.12265845,0.04135566,-0.00016424418,0.028782114,-0.0010139906,0.014393679,-0.040412992,-0.07389832,0.04986119,0.0036151242,0.054688264,-0.020537566,0.03451198,0.04744116,0.004235405,-0.039120346,0.022007737,-0.08140063,-0.073683396,-0.06440933,-0.0043266704,-0.03755953,0.029121276,0.11630531,-0.06618127,-0.022572054,-0.020034192,-0.043658316,0.10352907,-0.086180225,-0.069751374,0.006918968,-0.054191932,-0.038621213,0.0071984334,0.08716001,0.04795571,-0.025151918,-0.041149225,-0.069125205,-0.013734138,0.064647555,-0.029534517,0.015447015,0.04935854,-0.0112219965,-0.04728706,-0.113151714,-0.0040296563,0.04287074,0.026256552,-0.01312006,0.02314698,-0.11191987,0.010465944,-0.047425155,0.03878575,-0.058276962,-0.03607733,-0.04213298,-0.03287561,0.03126008,0.0053049,0.04391142,-0.047885753,-0.023228226,0.059326105,0.057977397,0.019069016,0.018886475,0.007850905,0.07245558,0.054237347,0.06917474,-0.02222474,0.064839885,-0.0693896,-0.030112095,-0.0835853,-0.084718525,0.011373758,0.02761133,-0.1536671,0.08585574,0.022046948,-0.039606065,0.087954946,0.038163304,0.010924397,0.028807748,0.010495605,-0.06830539,-0.12097035,-0.009449509,-0.04837032,0.05351321,0.10138315,-0.03199033,-0.040035307,-0.068972506,0.07654595,0.027342958,-0.05910441,0.05345778,-0.040943787,-0.007758354,-0.024984615,-0.037593115,-0.0011897329,-0.018753888,0.025880903,-0.013678931,0.015137876,0.01191807,-0.19295849,1.7448335e-33,0.12331441,0.02847601,0.039690983,-0.0016813225,-0.07308692,-0.021255122,-0.080277905,0.049572196,-0.0023100527,-0.08432692,-0.030873198,-0.11629344,0.04538935,-0.021322561,-0.01959685,-0.038826797,-0.056750305,0.002982876,0.079410516,-0.025663992,-0.040019833,0.05800782,-0.031589724,0.007159259,0.057382975,0.058040384,-0.035810698,0.0014340951,0.0472459,0.025067043,0.030447338,-0.016715057,-0.008413088,0.023377378,0.020344209,-0.017810117,-0.027714305,-0.089762904,-0.06710445,-0.024626419,0.009214047,-0.0067360396,0.023765434,-0.076371044,0.07448907,-0.05982291,-0.063341774,0.022315463,0.029742781,0.005849464,0.0517003,-0.028952373,0.17137152,-0.020530136,-0.06045241,0.011944312,-0.02766527,0.010394919,-0.016824786,0.028845577,0.0153591875,0.08094577,-0.021012643,0.068186335,-0.002600092,0.01336547,-0.05919005,-0.048594277,-0.022324165,0.09152915,-0.012024131,0.034450304,0.018124724,-0.0059408178,-0.013692727,-0.040220447,0.032221865,-0.004927479,0.019702192,0.014456182,0.006808273,-0.06956492,0.053078555,-0.04877029,-0.0016051974,0.020879963,0.005834545,-0.06310398,-0.004544536,-0.0101920655,0.025468474,-0.06679886,-0.030794395,-0.019587787,-0.005093027,-2.189355e-33,0.0841147,-0.064643614,0.027428236,-0.032587707,0.027518423,0.08268632,0.017967828,-0.051478527,0.003965693,-0.0015634792,0.035642497,-0.020792827,0.08824197,-0.048907068,0.055261888,0.0077454667,-0.028439881,-0.06886577,0.040420335,0.0028013608,-0.022699952,0.09981959,0.0076832385,-0.017607013,0.013820792,-0.029240461,0.003507423,0.06406775,0.03447008,-0.0012689709,-0.0014056045,-0.023479532,-0.03435529,-0.085287765,-0.0019279217,0.0055004153,0.0123072155,-0.01596966,0.022434808,0.03377125,0.015251217,-0.07229503,0.041120876,0.02675557,0.037206754,0.037305634,-0.07162121,-0.02593846,0.059585232,-0.03913143,0.05445657,0.020066442,-0.03358595,0.027631423,0.014475971,0.020448258,-0.005226856,0.04568742,0.04478473,-0.0792063,-0.0701921,-0.05483541,0.054249745,0.12093371,0.004347912,0.04622571,0.005661561,-0.027772151,-0.04444978,-0.013535554,0.088693485,0.022330934,0.0423147,0.14533548,0.02810439,-0.07460439,-0.0010383619,0.011332004,0.0410889,-0.039526094,-0.030229533,0.023226595,-0.05326986,-0.04304986,0.122183815,-0.03444899,-0.050430004,0.10156181,-0.05411553,0.0073446273,-0.0240707,0.08434796,-0.008095889,0.038991142,0.058111604,-3.0170156e-08,0.058498178,-0.07246254,-0.011103489,-0.041028697,-0.0021891845,0.014134264,0.054965977,-0.013623852,0.024791151,-0.0005289438,-0.013991209,0.11004942,0.0806553,0.017780274,0.01731553,-0.031283997,0.016182171,0.03376425,-0.06096332,-0.11532263,-0.09249623,0.03021544,-0.03901201,0.031165374,0.024593893,-0.038660776,0.03752042,-0.008182753,-0.015408176,-0.067049846,-0.009292198,0.06218064,0.045863803,-0.02951766,0.0027048755,0.08418609,-0.0062533943,-0.00032338037,-0.051046338,0.05016091,0.05233727,-0.011619016,-0.012511969,-0.037654698,0.021213286,-0.00036642517,0.012152631,0.018698728,-0.026126472,0.011566013,0.047552448,0.03471355,-0.046800796,-0.07101672,-0.10933268,0.034047797,0.039352603,-0.04148082,0.024353655,-0.04273769,0.123768464,0.016074728,0.15088092,0.020886632 +1.14.99.24,An enzyme system involving a flavoprotein (FMN) and two iron-sulfur proteins.,384,1.0,-0.054865316,-0.08127507,-0.1581855,0.0973089,0.045355413,0.05373374,-0.018818228,0.044501275,0.03194098,-0.11015189,0.022481937,0.029754579,-0.061597686,0.0039051718,-0.072472766,0.022123203,-0.046923727,0.02514392,-0.041057594,-0.025311204,-0.013780276,-0.038555928,0.0026029036,-0.050558414,-0.07864704,0.04368855,0.03898578,-0.003321735,-0.08628139,-0.039673954,0.064284325,-0.022073815,0.039842684,0.0050345864,-0.0483414,0.04498955,0.016304573,-0.06939647,-0.067223616,-0.049360793,0.042983662,0.017515756,-0.034643605,-0.065762945,0.042848315,-0.03700505,-0.027910694,0.057923403,0.04360986,0.03109641,-0.08942093,-0.055753835,-0.053789765,0.09416404,0.027958168,0.027293582,-0.035258725,-0.035255425,-0.04784239,0.038947828,-0.008349503,0.0051520932,0.026169548,-0.041766062,0.07765396,-0.039588448,-0.010464529,0.009820747,0.019576523,-0.023516411,-0.04339472,0.016884299,-0.11475174,0.030317735,0.011694838,0.0740462,-0.023642054,0.010010336,0.07960652,0.011222904,0.021964788,-9.910451e-05,0.04125912,0.108087026,0.023280678,-0.042107232,-0.060625557,0.019175457,0.003952515,0.080502026,0.007912954,0.027224852,0.033256035,-0.0020942548,-0.0120623745,0.046797413,0.011467504,0.0833477,-0.058205184,0.033453155,-0.04394442,-0.04866177,0.024515307,-0.07245678,-0.01776653,-0.03769297,-0.027882392,0.08552914,0.048374865,-0.04328664,0.0054514473,-0.03663922,0.03731922,-0.066889636,0.035071008,0.07079207,0.03754974,-0.025055598,-0.021589134,0.040672656,0.018773321,0.13087068,0.040576164,0.10930123,0.023802523,0.0009532495,-0.14920656,-1.7792183e-33,0.056904774,0.058871556,0.06308867,0.0021065513,-0.024815103,-0.033187404,-0.023985384,0.036004994,0.023709148,0.0351374,-0.115809046,-0.0031807723,0.024832956,-0.093732156,0.050303224,-0.053984847,0.0142532475,-0.040543903,0.08533397,-0.03457691,0.023489704,0.033074465,0.01630251,-0.0065847975,0.044513207,0.036177527,-0.025847562,0.0079053445,-0.042311016,-0.00050203444,-0.0042564035,-0.0846054,-0.05204595,0.007527833,0.067886055,-0.02431938,-2.3095072e-05,-0.069060184,-0.10864072,0.024572795,0.009811773,-0.041093487,-0.044743553,-0.023910534,0.027187021,-0.025350265,-0.12799753,0.08779862,0.016780272,0.06359523,0.016922358,-0.024058977,0.11620049,0.06584202,-0.08821232,0.03928331,-0.027828924,0.01159741,0.021220801,0.020999903,-0.021836635,0.028289365,-0.008236807,0.03426749,-0.00056262437,0.0036448871,-0.037364393,0.0051537403,0.02036557,0.1014615,0.034450963,0.009453179,0.084419176,0.011550549,0.018933844,-0.04867579,-0.07605855,-0.04615745,0.005488248,0.058991086,-0.023989456,-0.05333703,-0.04482867,0.0143393595,-0.10482146,0.020188581,-0.027854307,0.016614208,0.01176239,-0.067755446,-0.00022062076,-0.006635236,-0.022304608,-0.012984636,0.010912552,1.0716386e-34,0.002753356,-0.080053195,-0.04176363,0.01569106,-0.02855607,0.0254629,-0.008847056,-0.056208972,-0.052127123,0.047117602,0.06741738,-0.09668524,0.028916232,-0.06407158,0.006483156,0.09605278,-0.04765197,0.07044622,0.09092952,0.021323813,-0.09805207,0.045131635,0.016829044,0.07248793,-0.003222585,-0.01655348,0.0708761,-0.0043389318,0.048389677,0.11145813,-0.04335762,0.017037844,-0.02040583,-0.089177646,0.019607428,0.024987439,-0.0020789835,-0.02000635,0.056380726,0.005262385,0.009874237,-0.0018891486,0.04629827,0.11602605,0.04928135,0.08562189,-0.036857847,0.08907381,0.019084316,0.0038526151,0.024928194,-0.027997859,-0.042508345,0.08327798,0.004231954,0.025344934,0.059709724,0.063749455,-0.04185121,0.023297928,-0.047694806,-0.14649184,0.028686602,-0.023395801,0.019884367,0.08887412,0.007079661,0.05698692,4.294347e-05,-0.044641215,0.05472315,-0.038585078,0.08404083,0.042619552,0.0201587,-0.029477227,-0.015818434,0.116833076,-0.026017897,0.0066470164,-0.0021539566,-0.03546781,0.010893464,-0.10510355,0.030758085,-0.10858766,0.0071110665,0.067238525,0.015203864,0.023677986,-0.024607485,0.016964933,-0.05689425,-0.048277844,-0.056185752,-2.1639401e-08,0.022477055,-0.061856497,0.031352196,0.013034697,0.043432966,0.03296624,-0.0067724437,-0.025569532,-0.074158624,0.06402438,-0.02502448,0.11237872,-0.04738171,-0.0087207295,0.019169768,-0.018210161,0.029996613,0.07970794,-0.009118207,-0.02314495,-0.024038367,0.03235385,-0.07823671,-0.0065098894,0.014559325,-0.06605952,-0.031297702,-0.050556734,0.083288066,-0.024507813,0.023190834,0.054236654,0.008673003,-0.032072924,-0.14485346,-0.0149900215,0.0068638907,-0.06188682,-0.035061523,0.023234457,-0.117443,0.011597462,-0.043389045,-0.028420491,-0.006567645,-0.023002464,0.040235456,0.024471119,-0.019795354,0.01669971,0.028012078,0.012626149,0.0042337673,-0.042995505,-0.02325643,0.04221075,0.096082,-0.05784285,0.019222794,-0.0409474,-0.016099578,-0.008660843,0.10173502,-0.01349466 +1.14.99.26,"Also oxidizes 2,5-dihydroxypyridine, but does not act on 3-hydroxypyridine, 4-hydroxypyridine or 2,6-dihydroxypyridine.",384,1.0,0.016119113,-0.15292981,0.051149834,0.0155016435,0.061344765,-0.07475052,-0.04571808,-0.03869793,0.01955316,-0.055168718,-0.0069591394,0.059849765,-0.011972941,0.08471154,0.024764046,0.08954593,-0.043519348,0.046485547,-0.013819617,0.021889508,0.034455966,0.008761,0.035879605,0.033279426,-0.030197823,0.053618822,0.0141681265,0.0961474,-0.039649945,-0.078965545,0.035216294,0.060368635,-0.096971974,-0.011290925,0.031562105,0.054858994,-0.055975776,-0.0006344714,0.048647746,0.05527506,0.022298468,-0.039112423,-0.021569757,0.012828159,-0.013530469,-0.017773328,-0.02783304,0.009541337,-0.01078741,0.036612988,-0.046259895,0.0061354763,-0.025502466,0.062771715,0.024674876,-0.06000357,-0.043259796,0.05968049,0.005128469,0.030603688,-0.07033291,0.005705251,0.019453606,0.014683821,-0.03233381,-0.0082758,0.036152717,-0.06983562,-0.03212744,-0.05387658,-0.0824267,-0.066691145,0.111971155,0.035059404,-0.035751328,0.004662608,-0.030015387,-0.079346836,0.046362966,-0.07594554,-0.08677273,-0.057409927,0.019483851,0.08491627,0.02275166,-0.06848798,-0.08585455,-0.0746877,-0.021045271,0.01491369,0.018193183,0.06612088,0.014740951,-0.028511373,-0.026012693,0.009493436,-0.006054547,0.05290683,-0.04232762,0.014858866,-0.029822618,0.029398717,-0.114974774,-0.0515466,0.00794185,-0.05159601,0.032496035,0.00076605007,-0.073512234,-0.05006188,-0.032433394,-0.021699928,0.055484254,0.031601336,-0.016610911,0.037520643,0.034691304,-0.039337937,-0.086184986,-0.048715733,0.00059183105,-0.06769693,0.062153276,0.00045611747,-0.117603846,0.052530516,0.04059762,4.020414e-33,-0.013060764,0.014609184,0.024918996,0.056907754,-0.0011303397,0.05320506,-0.0542805,0.021088237,0.08378984,-0.041259903,-0.025428183,0.0048274887,0.06624067,0.014493441,-0.0038429596,-0.00860559,0.01310937,0.01320783,0.06902703,-0.014937805,0.08900055,0.09191487,-0.05051514,0.010098202,-0.047104497,0.030091072,-0.015016248,-0.015760137,0.05806461,0.007285947,-0.015982091,-0.043912582,-0.025096899,0.0038650967,-0.041843142,0.0237184,-0.08618934,-0.006515102,0.0037389253,0.0019185848,-0.019561568,-0.0026114078,-0.037470266,-0.044963285,0.035756905,-0.028782437,0.0012507715,0.12603797,-0.006130683,0.028464481,0.06319199,-0.013541838,0.061432708,-0.059684154,0.008064804,0.004044721,-0.0070282584,-0.0008023604,0.081708916,0.049632587,-0.0030639204,-0.0016429278,-0.06875093,-0.06791636,-0.013867696,-0.02275695,0.041716956,-0.004066238,-0.0494674,0.037901226,-0.017023632,0.08458296,0.08523803,0.09243826,0.06850055,-0.02504837,-0.042299177,0.029723708,0.07912919,-0.01156736,-0.004758628,-0.050985504,0.08209549,0.06573613,-0.0027233283,0.017422605,0.029686723,0.02505506,-0.003443054,0.023900926,0.12296696,-0.1314213,-0.052339934,-0.055260766,0.063510485,-5.380374e-33,0.0136325,0.00061748846,0.0040634237,-0.035001434,0.031192908,0.023083368,0.024057575,-0.019485243,0.075987436,-0.063291706,0.10523097,-0.017539943,-0.03562855,-0.07000106,0.064772375,-0.0004409252,-0.033127494,0.026380183,0.005428307,0.026181987,0.0744905,0.008576517,-0.0386437,0.073877364,0.048235662,0.047605287,0.0067572906,-0.04174809,0.10139127,0.119878694,-0.028250009,0.03999703,0.023807175,-0.031726297,0.031602565,0.025831109,-0.10705701,-0.017978746,-0.11674779,-0.047797345,-0.026484111,0.0056773927,0.026564324,0.08763967,-0.008242605,0.033853326,-0.038131844,-0.010744342,-0.0022860405,0.027522948,-0.007142156,-0.00563668,-0.10177425,0.0026450194,0.071828865,-0.010775282,-0.035465863,-0.0484944,-0.03711655,-0.013911464,-0.07703044,-0.005861702,0.010788098,-0.032382328,-0.022443926,0.02617735,-0.035875894,0.06160068,0.108137794,-0.019531697,0.04704578,-0.02484384,0.019509584,-0.103285566,-0.047286686,0.006909493,0.0018520611,-0.0022296351,-0.043737076,0.03466986,0.064406164,0.017071348,-0.0031937829,-0.043133244,-0.015481968,-0.029637083,0.004346456,0.068546474,-0.013924287,0.041124176,0.00986827,0.0018235361,0.020269848,0.0038602,0.042820286,-3.683436e-08,-0.02916219,-0.020250663,0.17033327,-5.290927e-05,-0.017826771,0.008819871,0.02905243,0.05510224,-0.0023733105,-0.009142077,0.07720991,0.042955432,0.055126768,-0.07169739,0.0026588968,-0.071540914,-0.020961573,0.042102013,-0.025360065,-0.03479744,-0.12446533,-0.035436295,-0.034548678,0.0296108,0.014421613,-0.014823268,-0.042566154,-0.15187013,0.03953443,-0.095252536,0.10354815,0.020447804,-0.015945986,-0.064627364,-0.08848617,0.00945032,0.013628875,-0.033766918,-0.041884415,0.019488497,-0.07047502,-0.083225,-0.0833386,0.04100542,0.07224583,-0.0115709305,-0.058214672,-0.08249136,-0.04181509,-0.03418124,0.030881513,0.018010274,-0.011428992,-0.08110726,-0.05738487,0.029999949,-0.01785565,-0.023727763,-0.037311506,-0.104095906,0.0044823284,0.031195246,0.18857957,0.006539673 +1.14.99.27,"Also acts on 1,4-naphthoquinone, naphthazarin and 2-chloro-1,4-naphthoquinone, but not on other related compounds.",384,1.0,0.0010744015,-0.05731878,-0.056754787,-0.0078516,0.03575214,0.060191862,0.03968993,-0.0470631,0.047986325,-0.10445102,-0.0076294155,-0.053277936,0.0044628694,0.086432844,-0.027095085,0.050671823,-0.091770746,0.032832008,-0.051349334,-0.011065082,-0.0033911006,-0.03713954,0.0310283,0.040563338,0.005576161,0.028955374,0.009243508,0.012246848,0.010731909,-0.08855258,-0.034130428,0.018228162,-0.030750964,-0.01831367,-0.015350408,0.044540446,-0.059268788,0.028853327,0.024161344,0.085531354,0.058310848,-0.069629736,-0.006546864,-0.015576182,0.013111974,0.002588004,-0.059200693,0.051264662,0.04492264,0.0646224,-0.034775205,0.0071269805,-0.06696164,0.1464055,0.02050195,-0.015467799,-0.07796343,0.11011179,-0.008519574,0.028850805,0.025630228,-0.022388605,0.043815278,0.019427516,-0.023931518,0.018569386,0.023023605,-0.059242357,-0.05071074,-0.01759344,0.004047597,-0.05136349,0.026874097,-0.007931614,0.02543599,0.02165968,0.013016735,-0.039270967,-0.03319922,-0.09836145,-0.00601344,0.009126802,0.06442207,0.056204014,-0.051966857,0.0015396223,-0.012394889,-0.068014175,0.041064285,0.057105854,0.06757857,-0.014213629,-0.0141018145,-0.055840254,-0.07772537,0.03618531,-0.0046858,0.021983335,0.017504444,0.0071974867,-0.040597413,-0.04225424,-0.116741255,-0.08018422,-0.045175854,0.015762657,-0.03810823,-0.058687247,-0.012583353,-0.07284921,-0.014107388,-0.053220257,0.06549494,-0.042924844,-0.040934537,0.007664788,0.063179225,-0.015192271,-0.07509934,0.057377297,-0.02688539,-0.022233387,0.07243178,0.027616423,-0.05637733,0.03607425,-0.054466702,1.4250357e-33,0.08608062,0.011887293,0.02189642,0.00064577896,0.008838788,-0.03046175,-0.10237993,0.022937605,-0.06285853,-0.100884646,-0.014670854,0.0037444266,0.023067009,-0.05884545,0.0022454283,0.021523092,0.04105228,-0.068523966,0.022220198,-0.012569627,-0.051677555,0.14837098,-0.09428097,0.0032737975,-0.02445556,0.078699015,0.00035642297,0.04018645,-0.06623046,-0.0058635115,-0.005413356,0.017092956,-0.08896945,0.006576474,0.014239067,0.056111783,-0.0915455,-0.013621938,-0.016622402,-0.053416047,-0.030960849,0.0418726,-0.08763317,-0.064225204,0.03710727,-0.08305631,-0.050870154,0.08443302,0.06191911,0.07887187,-0.0051990417,-0.033845536,0.049351852,-0.01724442,-0.06810549,-0.026637834,-0.017987525,-0.016269652,0.08722922,0.056580566,-0.0012908962,-0.027411185,-0.067257814,-0.0850897,0.010755002,-0.006336001,-0.044645276,0.03781072,-0.04210517,-0.018224705,-0.012333644,0.027102008,0.054763082,0.027599925,0.099960916,-0.02168788,0.006293756,-0.0577147,0.0267058,0.0692112,-0.04064277,-0.044739094,0.1216223,0.005795016,-0.12034054,0.03419875,0.060929388,-0.03087788,-0.034343157,0.050771255,0.013037255,-0.02618532,-0.020044636,-0.0794085,0.058941614,-3.9860767e-33,0.045614436,-0.07215405,-0.02118678,-0.044311818,-0.013894431,0.03307801,-0.03563241,-0.09077548,-0.0031126312,0.061801422,0.15807967,-0.030446282,-0.0856552,-0.026617559,0.013244451,-0.019263532,0.010796888,0.11920539,-0.0030560326,-0.0031934408,-0.015610635,0.05322309,-0.07072312,0.1423312,0.021269763,0.017596437,-0.015095117,0.00089443015,0.043113884,0.11428273,-0.040605865,-0.039528765,-0.042657748,0.023658356,0.039896764,6.0871207e-05,0.017424038,0.021660035,-0.043467835,0.0034561686,0.048582166,-0.05384973,0.07041811,0.05291116,0.05169779,0.034856733,-0.040797107,0.084773235,-0.08518022,0.0018532908,8.874699e-05,0.048886806,-0.03767691,-0.005764729,0.07370131,0.06581845,0.028351802,-0.07561429,0.024817672,-0.0013468324,-0.007140145,-0.014881404,-0.03990945,-0.017748795,0.01893603,0.014562338,-0.0421223,0.010488766,0.10867188,-0.054593097,0.053696297,-0.040927384,0.06906135,-0.02888266,-0.08733099,-0.08307744,0.01767244,-0.058499653,-0.016113285,-0.03360737,0.013495471,0.0014917719,0.012662876,-0.04268888,-0.05361312,0.002073542,0.033610947,0.009392944,-0.026764682,0.02922791,-0.02161556,0.10222853,-0.0004795817,0.04327052,-0.019187957,-3.193246e-08,0.059138454,-0.044256385,0.069093615,-0.053024426,-0.019080896,-0.01654485,0.0140920235,0.02348172,-0.006503818,0.028367784,0.059957884,0.10055072,0.054572713,-0.025548263,0.06699375,-0.0062950067,0.01080549,-0.0025638032,-0.034661494,0.04812542,-0.08338983,-0.014953097,-0.09881479,-0.04949191,-0.01663493,-0.065464385,0.043841306,0.021713782,0.050450172,-0.048984077,0.10375627,-0.011271888,0.0060532116,-0.098438,-0.019416936,0.024130527,-0.0072863335,-0.038478944,-0.006669354,0.039314106,0.0049189115,-0.021668553,-0.023874963,0.058521997,0.04364274,-0.02169533,0.030642437,-0.117522225,0.0034338231,-0.03602076,-0.0056238333,0.017833019,0.02925435,-0.023327762,-0.09115401,0.059338924,0.06599225,-0.034666903,0.08579464,-0.10352032,-0.007336903,0.0076385825,0.14898255,0.052920353 +1.14.99.28,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.14.99.29,The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A.,384,0.9999999,-0.034332562,-0.039477155,-0.056420393,-0.04101587,0.04977738,0.065127015,-0.07406803,0.031795867,0.012959401,0.07314727,0.024621347,-0.03471537,-0.06641541,0.05819376,-0.01978438,0.013858759,-0.10090089,-0.04358484,-0.053210735,-0.12927137,0.09034406,0.032459352,-0.040731918,-0.018480714,0.011691911,0.0019712206,0.06513842,-0.01612952,-0.000110162495,-0.033423267,-0.044848327,-0.058172848,0.027380949,-0.045341555,-0.006908499,0.064902365,-0.056868933,-0.113155134,0.046572275,0.050543435,0.05890474,-0.020971559,-0.09333797,0.030544875,-0.018137878,0.037540425,0.07516642,0.038311966,0.055827126,0.038473547,-0.024915006,-0.06771465,-0.051723853,-0.07407239,-0.064308524,0.030572401,-0.017344931,0.010930868,0.08876806,-0.024458991,-0.05354101,0.051618885,0.0076865447,-0.016878879,0.0942281,-0.01244059,0.016958313,-0.05187527,-0.015730958,0.067837775,-0.034176018,-0.08170648,-0.022190437,0.025554352,-0.02516825,-0.03114446,-0.02674101,-0.04987579,0.01420244,0.008496595,0.002461915,0.0053736935,0.026855627,0.0801378,-0.0336586,0.022008594,0.040068805,-0.023889944,0.08276295,-0.057949807,-0.0039647412,-0.06113223,-0.012303629,-0.0336314,-0.020329764,0.020855661,-0.015480769,0.0076555996,0.01774684,-0.047855273,0.012693869,0.003468238,-0.03549196,-0.03102076,-0.028129814,0.012599994,0.020811467,0.0962369,0.029536368,0.03756057,-0.027181081,-0.027969472,0.035973445,-0.0074357907,0.059540253,0.06359147,0.02770244,-0.031288564,0.005524389,-0.039185073,0.052947942,0.021944275,0.08380031,0.037649088,-0.09528741,0.006760084,-0.12249478,-1.2371579e-33,0.06774822,0.007789941,0.031364914,0.03420174,-0.048136543,-0.020989478,-0.045899916,-0.012286223,0.028665002,0.042135928,-0.10769431,-0.07022584,0.04962936,-0.06007128,-0.0836318,-0.005948651,0.0031980847,0.004234432,-0.017766256,0.089522466,-0.040298015,0.035716154,0.03270165,-0.03645672,0.0017686223,0.047263004,-0.035185996,-0.016441312,0.065214224,-0.008674158,-0.0635218,-0.09894866,-0.117670536,-0.056707364,0.06160895,-0.016688788,0.09027878,-0.008090943,0.02853267,-0.011015296,0.053402312,0.021306518,0.0012723111,-0.04298211,0.07173094,0.017585687,-0.07021055,0.065250665,0.008437714,0.03404754,0.0019981756,-0.05525963,0.14468433,-0.0036684012,-0.08056496,0.0021745951,-0.03263387,-0.0018502768,0.036731504,0.09000145,-0.029864179,0.038894154,-0.005333565,0.10757391,-0.010750767,0.011665788,-0.037408903,-0.06132907,0.04471045,0.06916889,-0.07389254,-0.026047831,0.04954439,0.05321207,0.011586564,-0.061280504,-0.04286872,-0.0107634915,0.01497527,0.017006956,0.029616317,-0.04852059,-0.0011918755,-0.013165269,0.021722829,0.048306156,0.004679997,-0.056078576,-0.06539651,0.026000971,0.089388534,-0.079604425,0.09548499,0.035474934,0.02341817,-8.218392e-34,0.12734357,-0.15188104,0.0037305707,-0.07003127,-0.047727153,0.06231243,0.04596373,-0.05576524,-0.0019683444,0.024411831,0.09248707,-0.0017513053,-0.020527387,0.0043209693,0.037668116,0.0037676129,-0.008521546,0.1596343,0.062366474,0.03931589,0.016525237,-0.03693209,-0.0079837255,-0.030374613,0.09978932,0.016793149,0.017043663,0.08387014,0.036860425,-0.018482022,-0.05774155,-0.030556964,-0.014221425,-0.010778947,-0.037717965,0.049078427,-0.037643947,-0.007416043,0.033108406,-0.045298003,0.00056473457,0.035719447,0.030723667,0.05433569,-0.05557006,0.05815265,0.012221201,0.0673092,-0.07949596,-0.05894191,0.06990156,-0.11130686,0.0026796286,-0.030846333,-0.039068803,0.058907002,0.05759612,0.0478118,-0.004119709,0.064264685,0.0048897574,0.011015112,0.06601041,-0.015476751,0.02317619,-0.008049469,-0.061278466,0.075819775,0.01156211,-0.044978257,-0.00029162582,0.004599451,0.049817264,0.07651224,-0.018302087,-0.0258557,-0.02875785,-0.06309902,0.0789935,-0.057680737,-0.090373516,0.015307351,-0.053161617,-0.05019025,0.0026001933,-0.09933574,0.058097824,0.10739573,0.07666049,0.047323443,-0.017374417,-0.07299628,-0.0056298883,0.05854657,0.049212202,-2.4178524e-08,0.007974648,-0.014531977,0.04240314,-0.010728094,0.04415644,0.08146808,0.017512375,-0.036018204,0.07290896,-0.050822776,0.033813465,-0.0025747018,0.0137880845,0.035852123,-0.051383108,0.046693344,-0.043463033,0.05089176,0.013005961,0.014977657,-0.05884987,0.0053513767,-0.07230984,-0.010417095,0.048856266,-0.07790301,0.033807747,0.09269523,0.0049837497,-0.07631574,-0.048970733,-0.0057199467,-0.012843358,-0.038118087,-0.053930387,0.07134746,-0.02060794,0.016750881,-0.0370586,-0.058905434,-0.013883428,-0.02211994,-0.056189384,-0.052952584,-0.028753294,0.030443445,-0.015037433,0.01874753,-0.03867996,-0.057971932,-0.03522875,-0.006506831,0.035223387,-0.040570814,-0.04971714,-0.028104983,-0.03048586,-0.11868688,-0.006964323,-0.053113967,0.04987386,0.057948694,0.14467953,-0.023741435 +1.14.99.30,"Also acts on zeta-carotene twice to give lycopene and converts beta-zeacarotene to gamma-carotene, and pro-zeta-carotene to prolycopene (via double reaction)",384,1.0,-0.095657535,-0.043264985,-0.04560216,0.06787493,0.08529214,0.043579515,0.042029236,0.0772767,0.006070768,-0.030122139,0.03950702,-0.0054056305,0.021118708,-0.02221777,-0.012245985,0.03040742,-0.04286456,0.00079364254,-0.05928025,0.020724364,0.052543383,-0.08031411,0.04315487,0.04733263,0.0364951,-0.046834867,-0.02574436,-0.028229473,0.023838967,-0.023882333,0.017399725,0.040940627,-0.08221445,0.004612834,-0.037824046,0.016368456,-0.03403576,-0.020655163,-0.07597812,0.04058985,0.06345978,-0.087928295,-0.06916754,-0.04995249,-0.012837729,-0.036256675,-0.045208022,0.05391086,0.0076852916,0.04745276,-0.04611605,-0.045705445,-0.092354,0.029636983,0.022441251,0.095466696,-0.09465901,0.023414021,0.07558899,0.08956717,0.01278908,0.041608147,-0.026307322,0.0015348961,0.09520833,-0.05339172,-0.03311687,-0.041615635,-0.021543369,-0.029526707,-0.011734837,-0.04690829,-0.033920754,0.01293456,0.06102474,-0.003676166,-0.036485557,-0.01944774,-0.048344553,-0.036225498,0.021490466,-0.023749286,-0.012985365,0.01021232,0.036974832,0.033333752,-0.043382123,0.0381339,0.048309654,0.011997679,-0.003341528,-0.050256602,-0.020802252,0.027839847,-0.07511408,0.003082223,-0.032689076,-0.08289503,0.055441596,0.025969299,-0.032716896,0.028313277,-0.03365057,-0.08413671,-0.08713752,-0.014579366,0.036400426,0.034814592,-0.016133917,0.012151306,0.061549015,0.02741157,0.058169387,-0.015847087,-0.07757827,0.14427596,0.02120632,-0.035281263,-0.059471786,-0.028764665,0.025923338,0.012904789,-0.0022371933,0.03419748,-0.025284601,0.045599066,-0.056795094,2.637714e-33,-0.004394525,0.10878455,0.042959947,0.08617311,-0.01675523,0.036831073,-0.0753034,-0.014213209,0.025998103,-0.07263857,-0.03969512,-0.0066535017,0.04965665,0.09223278,-0.07761111,-0.029289378,0.011097738,-0.003081614,0.03236136,-0.016944623,0.02114325,0.0920434,-0.045798562,0.052905027,0.03256182,0.050309747,0.014154039,0.06297869,-0.0069693513,0.0125393,0.000204846,-0.023692774,-0.035532467,0.028309742,0.07870519,0.03034696,-0.06967346,-0.10254712,0.031355157,0.05426475,-0.024335008,-0.0035739532,-0.09460491,0.020907357,-0.0137549015,0.017046554,0.005178702,0.026701812,0.05004786,-0.06526586,0.046803452,-0.024950648,-0.03190617,-0.026493907,-0.06744398,0.11088646,-0.004620661,-0.04466724,0.019647121,0.03717505,0.011471415,0.035920613,-0.009590755,0.018741846,0.00995732,0.033164393,-0.06824839,0.005802686,-0.038814425,-0.041940488,-0.0755212,-0.0064773997,0.11368632,-0.016388245,0.06251232,-0.0044810767,-0.015318556,-0.05650107,0.056378376,-0.02127049,-0.07128608,-0.058559388,0.06664241,-0.030729637,-0.031216823,-0.009076527,-0.047618818,-0.10958977,0.05277563,0.040963903,0.018731799,-0.004283314,0.014610203,-0.058058336,-0.057811543,-3.5452366e-33,-0.053736314,-0.031273264,0.026777012,0.047819063,0.069126174,-0.018713726,-0.059362307,-0.22481467,-0.010168228,-0.021218196,0.082522504,-0.007883342,-0.0045832433,-0.06182224,0.0021036495,-0.008379824,0.052497637,0.05362647,-0.056056365,-0.0028900104,-0.029798595,0.030727657,0.021839526,0.025697963,-0.004344036,0.049979165,0.03655593,-0.01163712,0.13545182,0.08485905,-0.018188983,-0.064021744,-0.045836423,-0.09473111,0.006560555,0.0789518,0.03661178,-0.0064069605,-0.0021637585,-0.0051987562,-0.05069333,-0.06538249,0.045767963,0.0061946297,0.038202588,0.061260175,0.047346454,-0.058425177,-0.050406646,-0.036173355,0.060713593,-0.0018954003,-0.06309291,0.029874448,-0.03235646,0.015992057,0.08341896,-0.049743585,0.061912015,-0.021225838,0.02260598,-0.05674475,0.00081968465,-0.038794927,0.0117701925,-0.011121917,0.054522786,0.065411404,0.05023829,-8.369825e-05,0.1549712,0.029943332,0.028949466,0.046264667,-0.06595888,0.01538146,-0.042614788,-0.083605975,-0.04661716,-0.10410131,-0.028121782,-0.021874003,0.018089585,-0.06776582,-0.040603064,-0.040677268,-0.009410087,0.08610474,-0.012564875,0.008454347,-0.09230513,0.018907577,-0.012714902,0.08440926,0.120872684,-2.9058375e-08,0.0085711125,0.011422076,0.012612702,-0.003789834,-0.0092208665,-0.07079955,-0.0015626306,0.041298702,0.016890258,-0.010329976,-0.09799441,0.10249413,0.095618516,-0.07386987,0.065063424,0.001339835,0.025492622,0.085627526,-0.062168032,0.020435182,-0.009425433,0.024388839,-0.051385105,-0.06908892,-0.04694091,-0.08556741,0.017254872,0.10352999,0.027659675,-0.07355799,0.040974706,0.023894055,-0.011686552,-0.057194114,-0.061084993,0.030463304,0.024631485,-0.0033055206,0.046905164,0.028396724,-0.0019728863,0.01587734,-0.04845362,0.09726254,-0.06497364,-0.0012661017,0.02549538,-0.047708757,0.026524082,0.09026541,0.035632227,0.00040871266,0.004203894,-0.034715656,-0.07010882,0.047541484,-0.039655134,-0.0074666427,0.055343095,-0.07850022,-0.01666371,0.042160355,0.11623558,-0.00926432 +1.14.99.31,"Involved in sex pheromone synthesis in the moth Spodoptera littoralis. (E)-Tetradec-11-enoyl-CoA is formed by stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. EC 1.14.99.32, myristoyl-CoA 11-(Z) desaturase, forms the Z isomer by stereospecific cleavage of pro-R H at C-11 and C-12.",384,1.0,-0.087900445,0.0264207,-0.06692584,0.01958633,0.06941488,0.026880462,0.0038824677,-0.04588099,-0.032465674,0.00050260656,0.06693696,-0.10052872,-0.04052091,-0.008985863,0.023034297,0.05053649,0.009545282,0.013155062,-0.009504814,-0.026847024,0.07459097,-0.019022973,0.02392397,-0.016138442,0.0002505312,-0.049499948,-0.044588562,0.0038442737,-0.016731739,-0.098055676,0.044060327,0.05084575,0.032477528,-0.038452983,-0.018161858,0.0121220015,-0.05202806,-0.0778004,0.12679054,-0.0069087585,0.044254877,0.057035282,-0.10882126,-0.048931263,-0.13258648,-0.016154919,-0.04551907,0.004766013,-0.06514004,-0.031407252,0.033920996,-0.025749946,-0.001293757,0.13069235,-0.033077363,-0.011231586,0.06315366,-0.009103084,0.028323555,-0.0030496938,0.04370358,0.035502024,0.00019058023,-0.02338106,-0.021420559,-0.09130318,-0.05555781,-0.028576288,0.063699424,0.010883512,0.014633333,-0.027921828,0.005943005,0.04281712,0.0041787094,0.080797136,0.029044451,-0.07213332,-0.043925826,-0.014034764,-0.06939543,-0.0079994425,0.0077612,0.08260122,0.09856676,-0.060542952,-0.013279136,0.0015013572,-0.03445871,0.03988369,0.003135449,0.012194842,-0.0066976184,0.0159176,-0.071402535,0.056644954,0.024107317,-0.0019288379,-0.034299023,0.034912158,-0.03863394,-0.019500732,-0.11078991,-0.08461386,-0.10106864,-0.031559095,0.04033015,0.05186428,-0.009825769,-0.013116371,-0.06273298,-0.07339599,0.03695764,0.07150751,-0.090077154,-0.016345138,-0.03431169,-0.008517297,0.08767946,-0.015891096,0.064161725,0.019635854,-0.015689384,0.0393278,0.012290824,-0.039037675,-0.115566984,1.4534456e-33,0.056247495,0.054988425,-0.026063336,0.07423626,-0.034111485,0.020508628,-0.045446586,0.042322326,0.0020390342,-0.085620865,-0.058912892,-0.0122795375,-0.0039191134,0.014871793,-0.04905773,-0.02304798,0.06654159,0.02096275,0.0683009,0.005630242,-0.069201715,0.034532472,-0.0402321,-0.10321708,0.02120587,0.0878608,-0.1083919,-0.0060847816,0.01550779,0.010525259,0.13947447,-0.006182972,-0.031797457,0.14255019,0.12371553,0.04064385,0.01585209,-0.023792733,-0.052809857,-0.0041163224,0.043664742,-0.028314244,-0.057859182,0.012656207,0.010909224,-0.005054237,-0.06749671,0.08017139,0.08281042,0.0052546705,-0.009790521,-0.009023498,0.07234455,0.006955575,-0.06324537,0.0726081,0.029181486,-0.10197298,0.035095926,-0.026909992,-0.0030620354,0.04240052,0.06893542,-0.011953962,0.07950746,-0.03820384,-0.06075013,-0.035758335,-0.09506474,-0.0066798315,-0.046298902,0.0019401895,0.063002035,0.056901474,0.045022428,0.0660429,-0.013596719,-0.02249428,0.03308382,0.027008971,0.027502166,-0.01666175,-0.032028675,-0.054469924,0.0018065727,-0.08038881,-0.06599297,-0.03207612,0.0555884,0.115442574,-0.03210272,-0.07552106,-0.026682151,-0.035118036,0.014154285,-2.405523e-33,-0.03714899,-0.018134084,-0.022033118,-0.07850695,-0.054393053,0.053227276,-0.018394679,-0.025351914,-0.047510527,0.08667885,0.10829963,-0.036593847,-0.005541236,-0.04942675,-0.004274771,0.026204593,0.060022764,0.047701225,0.055927366,-0.06758814,-0.039645236,0.0834156,-0.022087967,-0.02402111,-0.020694073,0.025289671,0.11823239,0.08416875,0.081716284,-0.0037989286,0.039324727,-0.036604162,-0.028215224,-0.021593524,0.035990115,0.02579477,-0.07749383,-0.027600173,0.06979548,0.042379364,-0.06999069,-0.013477496,0.012673719,-0.0071131475,0.0585612,-0.049526785,-0.046072118,-0.005332319,0.03398827,0.037166677,0.06498092,0.012565707,-0.06653557,-0.087591805,0.0024551698,0.0066804145,0.039891183,0.013154408,-0.0035039596,-0.03994651,0.025837457,0.07753273,-0.026113098,0.055446498,-0.05998836,0.022708168,-0.0011455414,0.07406804,0.051365577,0.0039366386,0.07808227,-0.0105313165,-0.0020436833,-0.007989201,-0.09477042,-0.11102771,-0.0008338673,0.0027160433,0.057772413,-0.043749448,-0.0076464913,-0.018732259,0.036645688,-0.058604106,-0.005527421,-0.030795148,-0.07803637,0.07548517,-0.016687663,-0.029160198,0.0015077211,0.013382776,0.036865674,0.10875565,0.060840875,-3.802884e-08,0.018890178,-0.06430945,-0.015294631,0.011945941,0.01888208,-0.030862462,-0.05243129,-0.16597247,0.008288888,-0.04697821,-0.014552334,0.022807298,0.091170534,-0.016964654,0.06299709,-0.0128630325,0.075624995,0.03992611,0.008775871,0.010718866,-0.017879447,0.028023297,-0.06519288,-0.041051142,0.03834669,-0.019442884,0.053450994,0.013394746,0.0126194935,0.0057854434,0.07919159,0.05899211,0.031006446,0.022566022,0.047831595,0.040821638,-0.049179174,-0.06928534,-0.019066162,0.016247286,0.016175603,0.05304019,-0.014011867,0.016544517,-0.0033747384,0.00033200238,0.038972326,0.0141852,-0.033374388,0.09591766,-0.049237847,0.09224719,-0.026344214,-0.023777938,-0.09794519,-0.019948673,0.037488222,-0.015070103,-0.054710373,0.01305878,0.04089893,-0.0065567787,0.04719801,-0.021269698 +1.14.99.32,"Involved in sex pheromone synthesis in the moth Spodoptera littoralis. (Z)-11-Tetradecenoyl-CoA is formed by stereospecific removal of H from the pro-R positions at C-11 and C-12. EC 1.14.99.31, myristoyl-CoA 11-(E) desaturase, forms the (E)-isomer by removing the pro-R H group at C-11 and the pro-S H group at C-12.",384,1.0,-0.067875795,0.038464576,-0.0607305,0.03337371,0.05335381,0.039870143,0.01140496,-0.06617482,-0.027445737,-0.011283135,0.07095296,-0.08603566,-0.034462236,-0.020382885,0.017160868,0.046978876,-0.00874071,0.0057022767,-0.013709234,-0.039722256,0.082120515,-0.02857782,0.025075985,-0.033977125,-0.015665175,-0.040062547,-0.051929947,-0.0024913668,0.010785382,-0.08642509,0.0392699,0.07404939,0.045175996,-0.048716348,-0.04220378,0.020204334,-0.05608558,-0.06816891,0.11482702,0.023097686,0.052468024,0.04123747,-0.10252937,-0.047348402,-0.13289738,-0.0041932496,-0.039418045,0.0024358016,-0.07974328,-0.032946248,0.03884337,-0.03520578,-0.005959645,0.1404722,-0.0259077,-0.0073336517,0.057846207,-0.00058975664,0.047032516,-0.019829871,0.050951272,0.05234924,0.0019792528,-0.021843815,-0.011266952,-0.08465892,-0.040951587,-0.038627468,0.06176755,0.003916419,0.031535216,-0.018522752,-0.014025999,0.037366867,0.016466951,0.07885265,0.03693748,-0.06883587,-0.038661756,-0.020463403,-0.085869476,-0.010206617,-0.0048493724,0.09271141,0.07218985,-0.058497626,-0.039982975,0.0031742742,-0.052394055,0.029762516,-0.010922745,0.022719555,-0.022960337,0.008447046,-0.08895753,0.06707733,0.041809704,0.005637612,-0.028122783,0.04208655,-0.02781506,-0.019583346,-0.13391651,-0.07038841,-0.10224216,-0.03577994,0.024270806,0.05139997,-0.009100615,-0.0052338107,-0.060639285,-0.054585733,0.037744757,0.054909386,-0.09678389,-0.035026155,-0.03779345,0.005093957,0.0912039,0.0018512929,0.057333384,0.02121176,-0.01325425,0.04010392,0.026777528,-0.042548623,-0.1117678,1.1858991e-33,0.06297701,0.06226199,-0.02721869,0.05817403,-0.014589773,-0.0026502782,-0.048604067,0.03747243,0.01127352,-0.08139561,-0.05471175,-0.020476121,-0.021875862,0.018062396,-0.03029662,-0.03283427,0.07518092,0.005767773,0.066335656,-0.00833448,-0.07601267,0.060983565,-0.035658088,-0.0858351,0.030436603,0.09202409,-0.10089089,-0.013786682,0.0026148944,0.012858734,0.1216528,-0.0013190678,-0.04625276,0.14356013,0.09227666,0.041126482,-0.0042677126,-0.02962008,-0.072673865,-0.00651024,0.041661207,-0.0358696,-0.04888103,0.025100252,0.018735055,0.004104534,-0.0746775,0.069729075,0.09396479,0.019520385,-0.034846805,-0.0033186811,0.09507389,0.013362889,-0.07538705,0.06883714,0.033075966,-0.099164665,0.024762979,-0.037846066,0.0128970165,0.050643858,0.077323325,0.0035759497,0.062964365,-0.021118145,-0.04916136,-0.05368406,-0.07854985,-0.021731718,-0.04614973,0.013463317,0.07061678,0.060282577,0.04575469,0.07123506,-0.012182452,-0.044884812,0.036926948,0.008882574,0.022252148,-0.015346126,-0.025555981,-0.057839144,-0.005509493,-0.08511108,-0.053622402,-0.029585555,0.07313875,0.104416214,-0.030458916,-0.07510575,-0.020929504,-0.036801673,0.013649347,-2.1779763e-33,-0.055793982,-0.0060731503,-0.024047794,-0.081369385,-0.058500003,0.04350222,-0.014962184,-0.0321223,-0.056561757,0.08153235,0.10655038,-0.042523835,-0.027887525,-0.04656603,-0.014378117,0.033765882,0.07345324,0.050184064,0.048053585,-0.06428428,-0.045033235,0.08403484,-0.041588083,-0.00338579,-0.030522877,0.01744411,0.12207573,0.06635616,0.09650406,-0.0009101967,0.04185271,-0.03746675,-0.01802007,-0.029034643,0.04500189,0.025802875,-0.08626251,-0.0036272584,0.062276263,0.056378838,-0.06382554,-0.011409934,0.026588902,0.0021763,0.06015053,-0.023669736,-0.046464574,-0.018165872,0.015789289,0.03694037,0.06383604,0.014059228,-0.06394468,-0.08254243,0.00084471924,0.009032945,0.030462297,0.01369665,0.0025949548,-0.049281143,0.022364372,0.053975396,-0.029491076,0.054164127,-0.06284207,0.038376857,-0.008195603,0.06389732,0.03668468,0.023499455,0.08339998,-0.018493515,0.020052262,-0.0046146708,-0.07733838,-0.118348844,0.0047512753,-0.0012620122,0.035159957,-0.041902546,-0.0059809037,-0.018596586,0.03062519,-0.051922232,-0.016444048,-0.04787938,-0.075576544,0.08339422,-0.013623568,-0.036701366,0.010242707,0.037091974,0.04351342,0.08387706,0.06403473,-4.065803e-08,0.013264847,-0.06538558,-0.014646488,0.015821373,0.029243246,-0.03308566,-0.043504097,-0.14684528,0.017029347,-0.030815769,-0.03593765,0.011655432,0.08955299,-0.037422083,0.06489869,-0.012794131,0.059821896,0.039261322,0.011809932,-0.0021639378,-0.024601623,0.03114116,-0.08032545,-0.039352696,0.04031177,-0.014317362,0.06416225,0.0036870455,0.007856181,0.012702473,0.08370674,0.079716586,0.03337623,0.04450009,0.03355292,0.050749034,-0.038017437,-0.051956628,-0.016360966,0.0075468663,0.0153381545,0.048816722,-0.01898803,0.02137032,0.014080099,-0.005085561,0.034583807,0.032628074,-0.029761909,0.07677581,-0.04131527,0.09636537,-0.035954636,-0.029656265,-0.09620193,-0.03512798,0.039256893,-0.019132793,-0.043237094,0.0020754691,0.052986145,-0.008688211,0.046896268,-0.032137044 +1.14.99.33,Contains non-heme iron. ,384,1.0,0.025025591,0.007010284,-0.04162913,0.116062194,0.07775342,-0.028022252,0.06911097,0.02707452,-0.002638393,-0.042472143,-0.016505541,-0.034576003,-0.070165865,-0.017863683,-0.03249887,-0.084138654,0.048947196,-0.012111374,-0.05304632,0.014003978,-0.025908802,0.07829057,0.04376624,0.045660794,-0.049899846,0.019521307,0.06206934,0.03038261,-0.028583627,-0.017848693,-0.015799783,-0.009817143,0.032608286,-0.0034129478,0.037565626,0.013719335,0.0059730886,-0.046734314,-0.017933527,0.013201197,-0.008503363,-0.06870632,-0.038467847,-0.012034872,-0.00784874,-0.004225567,0.030230973,-0.061885674,-0.02019284,0.07053472,-0.041399516,-0.050226394,-0.05998507,0.062305477,-0.010672811,-0.035257194,0.0467612,-0.006859497,-0.030290633,0.03006959,-0.018192558,-0.01035955,-0.10466023,0.015014201,3.7321617e-05,-0.010877679,0.05591151,-0.006659004,-0.025963476,-0.066101626,0.04076042,0.009259211,-0.081261605,0.08202066,-0.039325707,0.07393578,0.09542664,-0.041181788,0.0757381,0.0594713,-0.09684603,0.052473247,0.057092752,0.12805288,0.04945248,0.059861027,-0.031438902,-0.03989347,-0.129892,-0.0015053829,-0.018890638,0.04589049,-0.022662096,-0.03120715,0.028043402,0.042840824,0.030344693,0.09708592,-0.029784232,0.0009841212,-0.05162627,0.036139347,-0.030090688,-0.034745824,-0.08022308,-0.019326603,-0.012319742,0.0705843,0.09658261,0.0017285785,0.010042144,-0.014135215,0.04957342,-0.033552814,-0.060451504,-0.016899936,0.09241374,-0.0034600666,-0.0128933685,0.036769282,0.03561388,0.0077369073,0.07867904,0.0030558358,-0.070588544,-0.07810392,0.012268315,-2.791892e-33,-0.013401294,0.036485534,0.1036773,-0.01600448,-0.0848539,0.027165106,-0.10701518,-0.019560574,0.06288097,0.055385318,-0.056606527,-0.017662426,-0.008025764,0.0016943208,0.013036705,-0.053293146,-0.011660319,-0.05650571,0.07754146,-0.020599507,-0.02204656,0.06734691,0.045886148,0.015217507,-0.054652467,-0.03512897,-0.011203597,-0.07553795,-0.048471354,0.014707746,0.026280817,-0.032002892,0.012687871,-0.043633427,-0.015639838,0.030377189,-0.06647211,-0.009883467,-0.09079231,0.044637192,0.07604478,0.02697688,0.044440825,-0.01174355,0.024339318,-0.08598193,-0.07052867,0.008932537,-0.03989746,-0.002417879,0.008767636,0.074571945,0.06958223,0.0038029249,-0.03455827,-0.0022370925,0.034748234,0.05078043,0.05862811,0.08411354,0.045332566,0.08253461,-0.0025225482,0.08274431,0.012936673,0.043615375,-0.06330476,0.029456472,-0.0017934754,-0.016185733,-0.0024850587,0.04189801,0.13222927,-0.01421807,-0.013592474,-0.06007244,-0.040399972,0.012487074,0.11037641,-0.05708382,0.0018347205,-0.07831338,0.030842325,0.023497298,-0.054787107,0.042133056,0.0047465162,0.025366498,0.026354298,-0.06487577,0.03847425,-0.0844694,-0.08748585,-0.11793957,-0.008715219,2.013844e-33,0.034930855,-0.032083254,-0.048149742,0.0006756775,0.012557041,0.025132684,0.0021044821,-0.022956599,-0.002845179,0.0019024439,0.16991526,-0.043928005,-0.0414729,-0.046553474,0.042598892,0.13287494,-0.0210499,0.05852375,0.012776228,-0.022129107,-0.024051186,0.018284893,0.026347071,0.03284114,0.018501798,-0.0071438234,-0.07875276,-0.027593693,0.030134069,0.04679503,0.055547256,-0.031066643,-0.03956428,-0.07453988,-0.112823926,-0.062879264,0.03537138,0.03934316,0.011370372,-0.0068534142,0.0048488625,-0.036299072,0.104504034,0.14333779,0.021045716,0.048914902,-0.0934755,-0.027298028,0.027590556,0.08395543,0.013729193,-0.019370176,-0.09214791,0.006189282,0.020425467,-0.035358984,-0.046804063,0.016572315,-0.112711795,0.008706831,0.036003824,0.05239584,0.03555445,-0.00975521,0.07787937,0.046785302,-0.084251866,0.060104907,0.014026273,0.007863646,0.07611331,0.032890033,0.019854058,-0.11093708,0.022580536,-0.022055805,0.0731115,0.044736225,-0.022991175,0.021790534,-0.04702059,-0.029885061,-0.061807584,0.00645853,0.048287515,-0.051317945,-0.060267534,-0.049849205,-0.034210723,-0.016020477,-0.0697096,-0.030167207,0.011978337,0.017517585,0.02905013,-1.4537137e-08,0.009485223,-0.061665438,-0.029516192,-0.023376076,-0.01604747,0.005260838,0.056938093,-0.019780902,0.02345306,0.057142653,-0.036105968,0.044451185,-0.029703509,-0.02097192,0.003707107,0.018901693,0.009744471,0.09541539,-0.013151316,-0.04110432,-0.02189614,0.039763257,0.028029565,0.0075343917,-0.023679646,-0.049434345,-0.022484189,-0.10970827,0.077677816,0.021897312,0.0255116,0.050761607,0.014138067,-0.019939587,-0.0308415,-0.023701124,0.050938986,0.029307604,-0.098655194,-0.027420156,-0.04720168,-0.03965131,-0.052771926,-0.018123984,0.03115424,-0.043580174,-0.03356086,0.062514804,-0.03183143,-0.03299865,0.058857627,0.034104064,0.061653096,0.012868777,-0.051457748,0.059151433,0.08898081,-0.06750797,0.089694396,-0.036887776,0.031903986,-0.10715587,0.16065027,0.017419782 +1.14.99.34,"A flavoprotein (FAD) with high specificity for monoprenyl isoflavone. The product of the prenyl epoxidation reaction contains an oxygen atom derived from O2, but not from H2O. It is slowly and non-enzymically converted into the corresponding dihydrofurano derivative. The enzyme in the fungus Botrytis cinerea is induced by the substrate analogue, 6-prenylnaringenin.",384,0.99999994,-0.040374525,-0.044525396,-0.06098467,-0.008535781,0.09630736,0.055510435,-0.05432447,0.08373646,0.029982336,0.023044106,0.105229214,-0.0012248381,-0.09897602,-0.048549578,-0.08527424,0.025000487,-0.052138012,0.02568786,-0.07374327,-0.04782585,0.02485745,-0.012030057,0.033332177,-0.044140175,0.032335285,-0.039656933,-0.0040289466,0.015022706,0.027006228,-0.03259461,0.11890312,0.039131466,0.057430048,-0.007696408,-0.05307813,0.06942958,0.03840694,-0.033742227,0.049048964,0.054697268,-0.01032615,-0.06538146,-0.009377421,0.01616202,0.023967605,-0.027470278,-0.0048447615,0.09742069,0.0066740685,0.011036048,-0.041796442,-0.05871842,-0.03743627,-0.03314327,0.037824444,0.041495293,0.023712905,-0.092143886,-0.0042040604,-0.010416831,0.003960232,-0.035741825,0.03198632,0.019567544,-0.016355518,-0.029838612,-0.038809158,-0.040726006,0.027085032,-0.016349029,0.0061435755,-0.013781128,-0.07368709,0.012071481,0.026346369,0.10515511,-0.08166504,-0.04622898,0.038405653,0.027196022,0.09856257,0.020557627,0.11021072,0.033276677,0.018183747,-0.002797888,-0.015576821,-0.04437214,-0.014174367,0.06731888,0.0013760041,0.0069110994,0.018468913,0.035229687,-0.106987424,0.084256135,0.036585353,-0.05677211,-0.053151313,0.010857109,-0.04847586,-0.048434407,-0.05258945,-0.039071534,-0.086570665,-0.06852826,-0.015427632,0.036368635,0.0089931255,0.026723633,-0.012167282,-0.040287606,0.024429118,-0.04705936,0.003024823,0.03227019,0.025242778,-0.046188354,0.07802508,-0.056465626,0.013288985,0.12679844,0.026869092,0.05066867,0.002550545,-0.04172674,-0.031229394,3.5015538e-33,0.074687555,-0.011952186,-0.03924546,0.011451625,0.0029589382,-0.029394336,-0.04570227,-0.0077232495,0.04487397,-0.035614077,-0.092563264,-0.00587649,-0.042987157,-0.011561931,-0.015573964,-0.0115624145,-0.0074994657,-0.005336185,0.08967391,-0.056096338,0.07139816,0.027754046,-0.03405012,0.038978003,0.041790746,0.046590198,-0.031065028,-0.010190939,0.058139272,0.01211796,-0.018579995,-0.06474064,-0.046966236,-0.0183145,-0.04668428,0.0018568102,-0.0540287,-0.055858683,-0.12228493,0.043214057,-0.025137356,-0.0067386343,-0.03730151,-0.05734886,0.09396232,-0.07183897,-0.09083673,0.10991399,0.04714215,0.01843263,0.030496327,0.022252139,0.117556565,0.12183999,-0.040931903,0.022705436,-0.015297459,-0.0013255143,0.040237714,-0.004154805,-0.014637154,0.08439616,0.012286437,0.056482717,-0.03844179,-0.010377519,-0.011265207,-0.07247924,0.0026475163,0.10577197,0.0106864665,-0.014673093,0.018115563,-0.0007404971,0.04538646,-0.031806067,-0.08372673,-0.020207113,-0.024942212,0.026128499,-0.03108853,-0.008712039,-0.0074049714,-0.040472955,-0.022571277,0.0047969427,-0.08393274,-0.021286616,0.040634327,0.015090586,0.011591259,-0.049001355,-0.057384785,0.03930551,0.054193765,-3.139523e-33,0.06166567,-0.11878758,0.059646055,0.026846677,0.02799531,0.093388155,0.023536777,0.018920086,0.0064757685,-0.048197784,0.0021728117,-0.08642729,-0.0062831407,-0.022885777,0.027282294,0.008385397,-0.008293799,0.089260764,0.04500558,0.07597972,-0.06316745,0.064312816,-0.013832494,0.07975443,0.073738635,-0.019413162,0.030608205,-0.0037803145,-0.031787176,0.062450618,0.012894072,0.0056223893,-0.00505393,0.008233043,-0.041893415,0.06737002,-0.037025347,0.011349839,-0.024066465,0.052654926,0.00076177326,-0.04288989,-0.017410727,0.02470883,0.04884572,0.034279596,-0.12130295,-0.0027585684,0.096795015,-0.02810422,-0.005161974,0.07839892,-0.0042416765,0.065331966,0.08743069,-0.010579458,0.043627206,-0.010949247,0.024346912,0.023687657,-0.010180028,-0.14485325,-0.007791939,0.0019139275,0.11237194,0.061432455,-0.03045556,0.12109087,-0.0043892968,-0.03336047,0.115975395,-0.009441348,-0.011422063,0.05440415,0.05895948,-0.014294099,0.009014887,0.047021467,0.008697581,0.0547675,-0.02911408,-0.029710421,0.025308184,0.023927893,-0.091956824,-0.11200125,0.035903193,-0.0011311499,-0.038937733,0.028654119,-0.0024699976,0.05803748,-0.039994977,-0.034656875,0.09850061,-3.8684494e-08,0.018124897,-0.042339362,0.07110668,-0.038546335,0.030258255,-0.016906004,-0.0037613818,-8.226518e-05,-0.037769325,-0.023637757,-0.030132746,0.13466704,0.039706744,0.0047573065,0.04828984,-0.067908555,0.003107013,0.07135126,-0.022489745,-0.019588858,-0.05281734,0.05870239,-0.07449456,-0.094050646,-0.039294407,-0.07732431,0.008670631,-0.0072039086,0.054244265,0.018383106,-0.006218388,0.019689783,0.046714008,-0.041688163,-0.12781882,0.07403786,0.018442579,-0.07850461,-0.05354412,-0.0049073165,-0.108403936,-0.038264707,-0.015853604,-0.07963806,-0.02666467,0.0017765668,0.044715557,0.008795381,-0.037407544,-0.021424748,-0.0016742747,0.03746315,0.017583838,0.00032952378,-0.07626159,-0.023141325,-0.007452545,-0.030526344,-0.034800965,-0.10915466,0.027174184,-0.013966718,0.17095992,0.02673934 +1.14.99.35,A molybdenum enzyme. Highly specific for thiophene-2-carbonyl-CoA. Tetrazolium salts can act as electron acceptors.,384,1.0,-0.080155276,-0.04892756,-0.10013486,-0.019433983,0.091859035,-0.057573844,-0.015775595,-0.026740318,0.0022623262,-0.0056238608,0.063724056,-0.049804136,-0.039692406,0.08699612,-0.019918308,0.017787926,-0.022432074,-0.0022467584,0.021832062,0.023772232,0.011614753,0.06460149,0.076026805,-0.05520012,0.030780979,0.04540418,-0.028264701,-0.0031350113,0.028061222,-0.07753804,-0.007058,0.03198142,-0.020002883,-0.027627384,0.0055926894,0.12200452,-0.09674704,0.0021169153,-0.02534539,-0.012124357,0.021506106,-0.050436378,0.054148808,-0.096498266,-0.07574415,-0.09618714,0.09257729,-0.0026691493,0.023082824,0.01956095,-0.0006406824,-0.038390886,-0.0029081933,0.08096016,-0.11568657,0.035866246,-0.018572612,0.07087367,0.0037238256,-0.008937769,0.026415905,0.0414654,0.05994433,0.11446565,0.008919829,-0.030050715,-0.045895007,-0.050630987,-0.04570051,-0.06261193,-0.035043184,0.011795113,0.054216255,0.009952078,0.020087974,0.073367685,0.04322453,0.00012857237,0.08039431,0.007589975,-0.03230435,-0.03857082,0.010304367,0.07459485,0.04943446,0.053789932,-0.037812296,0.002024067,-0.027045479,-0.04568996,0.057074346,0.03202069,0.08067647,0.017322667,-0.06746338,0.045355517,0.052596815,0.0066636917,-0.018516604,0.003836916,0.0073292824,0.019175041,-0.03558769,-0.041630305,-0.0703554,0.021646881,0.0040347017,0.005303158,0.012763893,-0.0069555338,-0.049461048,0.025151577,0.09207227,-0.0062700235,0.01961948,0.028663576,0.015096731,-0.026851542,0.05457953,-0.04793062,-0.03157732,-0.011075091,-0.043664236,0.010178866,-0.0009756471,0.13826504,-0.105672084,2.4021067e-33,0.114192486,0.10325983,0.06378105,-0.047798328,0.039152354,-0.039087635,-0.05379825,-0.0060200808,-0.09519605,-0.06919407,-0.05120727,-0.014763911,0.067892246,-0.00095480017,0.034260593,-0.056031182,-0.023204941,-0.024067422,0.11687122,-0.021624444,0.0023923102,0.070948824,-0.070031844,0.07398782,0.00018195767,0.028354228,0.02643812,0.07977006,0.028522959,0.022077715,0.0033856072,-0.04910928,-0.06594452,0.0014870671,0.023801848,-0.024063943,-0.09299773,0.023565283,0.003877215,-0.080514915,-0.061921395,0.010112272,-0.052278325,-0.037116263,0.01940075,-0.040253654,0.0065317475,0.062162135,0.06356624,0.001850753,0.015377704,-0.0608366,0.0051274872,-0.0860099,-0.08492408,0.06317674,0.011810688,0.046017658,-0.0069296723,0.040407795,-0.046523243,0.060520235,-0.023948133,0.057487555,-0.092784256,-0.006534963,-0.019765908,-0.07997031,-0.035367552,0.021995088,-0.084661044,0.08826549,0.04618496,-0.0023134598,0.059629668,-0.022228854,0.030169565,-0.16390324,0.08428617,-0.03295995,0.043931387,-0.08843963,0.064503595,-0.040832322,-0.06787846,-0.06805257,-0.050670903,-0.0420982,0.03722831,0.044588145,0.06957592,-0.06137908,-0.0671559,6.418306e-05,-0.041689128,-2.6652395e-33,0.11416172,-0.035251092,0.083923586,-0.031486575,-0.04135003,-0.0042784507,-0.0076114037,-0.07885216,0.09565577,-0.035212457,0.077151865,-0.021844909,0.05943371,-0.09914353,0.0019492982,0.0008221249,0.025878804,5.060743e-05,0.06062108,-0.040933765,0.021933774,0.039896064,-0.02238088,-0.07646566,-0.014077118,0.07594893,-0.019774359,0.013911771,0.030744836,-0.005621309,-0.037798,-0.01106654,-0.030138161,-0.05363676,-0.031117609,-0.007135783,-0.05464721,-0.016874269,0.05940537,0.021435926,-0.022597015,-0.031863216,0.05833349,0.06113782,0.009626671,0.052105207,-0.058932494,-0.03156129,-0.035919216,-0.021098811,-0.026100758,-0.0021956952,0.02804755,0.03422315,0.036680132,0.11257207,0.010868099,0.00078003877,-0.017544592,-0.012819796,0.0014783139,-0.03391982,0.02200082,0.036107056,0.009891845,0.022706129,-0.10056232,0.03671027,0.05350617,-0.022766205,0.075205386,0.03175057,0.018939419,0.02929514,0.0159103,-0.03341309,-0.025582625,-0.036987007,-0.034149908,-0.07674133,0.0042853532,0.067654684,-0.005781455,-0.06830304,0.024379933,-0.010477044,0.0031553993,0.10193727,0.0209341,0.015697006,-0.03531302,0.019816445,0.018617062,0.07270739,0.12289169,-2.9258347e-08,-0.059893187,-0.070456736,-0.03260835,-0.10351177,-0.007602468,0.067854404,0.057364784,-0.013447753,0.07312624,-0.039546683,0.0036668216,0.09208571,0.07398091,-0.05519607,0.027648194,0.06711055,-0.05871069,-0.06779879,-0.019917479,-0.022648051,0.035870362,-0.038543843,-0.088561594,0.078923374,-0.022835733,0.00028147918,-0.012109749,0.054029793,-0.07374299,0.034844734,-0.092208974,0.007053352,-0.0058070985,-0.046250347,0.02618909,0.06760917,-0.046606302,-0.09705382,-0.06687468,0.018245904,0.05942572,0.02826578,-0.028581263,0.020674072,0.023473162,-0.011417247,-0.025008913,0.07022975,0.036720235,-0.033212,-0.026006332,-0.009779147,-0.06770933,-0.0033695456,-0.05501665,0.01580769,-0.024940351,-0.013154402,-0.048322015,-0.05750964,0.045765653,-0.011176974,0.103736065,-0.031282052 +1.14.99.36,"Requires bile salts and Fe(II). This animal enzyme catalyses the reaction in three stages, epoxidation of the 15,15'-double bond, hydration of the epoxide leading to ring opening, and oxidative cleavage of the diol formed. Thus only one atom of the dioxygen is incorporated into each retinal molecule. The nature of the acceptor listed in reactions (1a) and (1c) is assumed to be iron within the active site. Formerly classified in EC 1.13.11 as it had been thought to be a dioxygenase. cf. EC 1.13.11.63, beta-carotene 15,15'-dioxygenase.",384,0.99999994,-0.08497334,-0.044651955,-0.067720264,0.058409743,0.12922473,-0.048934188,0.031026807,0.011984403,0.023133462,-0.030644914,0.06003497,-0.059594,-0.08117151,0.0488042,-0.07226124,0.016607776,-0.04364824,-0.042283837,-0.013462354,0.03255836,0.011840457,-0.053519968,0.003463571,-0.041935116,-0.025020974,0.04300907,0.07666103,-0.056330413,-0.08463507,-0.09930574,0.010872765,-0.04405505,0.079968676,-0.052116983,-0.052013416,0.044731703,-0.055499967,-0.090931095,-0.013883472,0.022118954,-0.047831815,-0.008798322,-0.041312102,-0.025038745,0.036163647,-0.11809197,0.03649917,0.045948755,0.04894541,-0.0022956938,-0.009762611,0.010563355,-0.0403643,0.05164463,0.036049306,0.045817684,-0.095081784,-0.033781335,-0.004027951,0.023007208,0.018853823,-0.042232417,-0.05122794,0.0019483918,-0.010753188,-0.043524075,0.030754853,-0.13140722,-0.0014742522,-0.08819691,-0.04566701,-0.03512681,-0.0014216944,-0.07692259,-0.03313703,0.038848378,0.026623309,-0.016423766,0.08912836,0.029943444,-0.021924937,-0.018136783,0.041152425,0.07249912,0.13196042,0.050161555,-0.032340553,-0.004138165,-0.05563411,0.07932317,-0.03803959,-0.007652865,-0.038418688,0.018224686,0.015367774,0.02795216,0.08161712,-0.0019560175,0.01854976,-0.0073562115,-0.03306335,0.055478487,-0.014715348,-0.0752913,-0.06032232,0.0006839412,0.0411301,0.122146,-0.006614831,-0.024303237,0.056169294,-0.026920732,0.093057126,0.011607257,0.00538787,0.13595818,-0.011016694,-0.11897091,0.044636503,0.011529288,0.037690096,0.031541437,0.06564945,0.030242639,-0.034505922,-0.01444026,-0.055703957,1.5868794e-33,0.017955711,0.0578312,-0.04383604,0.003508126,-0.0044943625,0.047755677,-0.05745291,-0.00018959012,-0.03592889,-0.048384313,-0.07747733,-0.033428963,0.0627915,0.0039431476,-0.031728324,-0.055507556,0.027556418,0.029464455,0.08484772,-0.04634884,-0.041285392,0.038458463,-0.06540149,-0.029142315,-0.007852946,0.06119112,-0.11762874,0.037664417,0.031034246,0.020267475,0.11169305,-0.049293578,-0.056385867,0.037383053,0.0042518894,0.046852153,0.069533944,-0.013805276,-0.03332147,-0.04114103,0.07402744,0.036554202,-0.050304122,0.0168435,0.097306274,-0.031114955,-0.06532897,0.10512082,0.018865854,0.053348806,0.004673294,0.06853094,0.040910635,-0.12759233,-0.058514006,0.08711358,-0.014041641,0.056260634,0.0632786,0.09410961,-0.008684521,0.11291823,-0.028892582,0.06884025,0.01653482,0.010713523,-0.049377635,-0.033977695,-0.055349626,0.08333672,-0.040430177,0.04870296,0.063866176,-0.03735236,0.036963362,-0.026128018,-0.045065843,0.054793302,0.06400961,0.026404621,-0.043655455,0.03768054,0.0031477863,-0.056946624,-0.058011837,0.046913322,-0.0125519475,-0.044692036,0.031626627,0.051039536,0.06179546,-0.04792363,-0.0440896,-0.08649153,0.08454384,-2.846665e-33,0.041099876,-0.061617192,0.017982475,-0.037702933,-0.036158357,0.09488777,-0.009912673,-0.0586933,0.094805434,-0.018965038,0.06586789,0.012167096,0.033995923,-0.09086877,0.012681694,0.03940842,-0.051959418,0.08512589,-0.04961979,-0.0054764566,-0.0134107275,0.08007432,-0.013654043,0.020192329,0.022769058,0.05957835,-0.019404018,-0.032408066,0.052911434,0.04523488,-0.035691395,0.018219978,-0.024133628,-0.01138775,-0.009960198,0.010030327,-0.12607054,-0.047532655,0.023854868,0.07929715,-0.010198716,-0.056051143,-0.0130395815,0.07013942,0.00081296,0.043178815,-0.010396493,0.02681487,0.03229398,-0.03621818,-0.019672105,0.02299756,-0.05548369,0.018292403,0.0515101,0.07847409,0.03913303,0.008383913,0.05544161,-0.0130674625,0.04047782,-0.049958527,0.08856325,-0.0130274845,-0.00013533821,-0.03887311,-0.0581074,0.07464546,0.049480006,-0.016106322,0.079166554,-0.04166788,0.058723997,0.011371026,0.023493633,-0.023562202,0.008984525,0.024421053,-0.010249427,0.0020802817,-0.0270053,0.045529857,-0.01944506,-0.020464804,0.008034968,-0.11002625,0.017727567,0.041969836,0.011310249,-0.0018477368,-0.021873636,-0.03513528,-0.06955836,0.05114064,0.079343304,-4.3678412e-08,-0.011818791,-0.051482376,0.01915428,-0.06674366,-0.0041038203,0.053678337,0.017995987,-0.014102937,-0.02121164,-0.055827487,0.030552454,0.12107705,0.011970092,-0.0141617395,0.034286864,-0.010314219,0.0075285714,-0.010318019,-0.02527465,0.003170968,-0.07224557,0.01233746,-0.00067129516,-0.03370647,-0.0318578,-0.059966195,-0.044324256,0.009692596,-0.0537808,-0.0053351987,0.020017942,0.061452355,-0.009663202,-0.037215557,-0.08174853,0.008103313,0.01562563,0.0070724846,-0.06026788,0.04660674,-0.042123552,-0.10328293,-0.067692846,0.0034705966,-0.05626876,0.045335926,0.008030275,0.018020796,-0.050864935,-0.0050020986,-0.061413933,-0.048637513,0.027971731,-0.048541974,-0.095311545,0.06565803,0.011694428,-0.043664683,-0.022138666,-0.062867284,0.006097646,0.05668092,0.13744506,-0.035368353 +1.14.99.37,"This microsomal cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.",384,0.9999999,-0.008605033,0.0076737064,-0.01677759,-0.017201511,-0.022241548,0.006067103,0.023300743,0.07019676,0.05622656,0.03678563,0.023501758,0.0724839,-0.014409979,-0.016121775,-0.029905256,0.055474747,-0.07479919,0.024377936,-0.0039448105,0.02983575,0.06618863,-0.049815398,0.067231365,0.021947991,-0.03289475,0.0225256,0.014855265,0.06520244,-0.020207522,-0.06401147,0.073408276,0.04911755,-0.0281089,-0.028951945,0.030727673,0.043669574,-0.05783647,0.0209887,0.027322756,0.015333713,0.07446224,-0.058601562,-0.06991827,0.02695996,-0.043935042,-0.1531301,-0.090192996,-0.0046569807,0.09803912,0.06564287,-0.009348171,-0.028202463,-0.061391287,0.008925629,0.043047946,0.009398449,0.0047919042,-0.016943727,-0.014166754,-0.035850238,0.0082294075,0.032866783,-0.033770587,0.035516024,-0.03534031,0.052791823,-0.00049495616,-0.056937058,-0.0042685084,-0.046061017,-0.0838914,-0.06757174,0.014093175,-0.027224788,-0.06431855,-0.003312088,0.018372571,0.020092087,0.031259667,-0.069681674,0.051341865,0.018789222,0.025883753,0.07216414,0.064817175,0.023396868,0.06816951,-0.0063871285,0.10037433,-0.022311464,-0.029680587,0.06964785,-0.021102246,-0.0075159497,-0.06726343,-0.0127616525,0.027606828,-0.018753199,-0.058319993,0.04766462,0.09257717,0.027018314,-0.063431695,-0.11534059,-0.040423173,-0.0007744971,-0.04998427,0.019736223,-0.018249776,-0.061431743,-0.028935876,-0.011513615,-0.008732953,0.04802664,-0.024237877,0.08630614,-0.0076845274,-0.06884968,-0.031309865,-0.112283036,-0.045899242,-0.05412473,-0.038457215,-0.010463536,-0.029917637,-0.032886907,0.0025222853,7.850161e-34,0.038213708,0.01973455,0.027631504,0.022714548,0.036813214,0.029290715,-0.03832863,0.0060808635,-0.16099195,-0.059570752,-0.08586385,-0.061207097,-0.024503086,0.027089156,0.0039419085,-0.05619824,-0.014242579,0.059424073,0.087469965,-0.01015544,-0.048973035,0.07307412,-0.0360326,-0.050942115,-0.046463877,0.12404052,-0.06718249,-0.0076216995,0.03239041,0.012299334,-0.063639395,-0.017697496,-0.022181885,-0.009624401,-0.024333945,0.033272002,-0.037004672,-0.016351035,-0.036919575,0.06947059,-0.03563896,-0.023655508,0.04331819,-0.042048253,0.0019135283,-0.031940613,-0.027278163,0.05281566,0.05309228,0.0038483145,0.013859879,0.011919159,0.055609234,0.0415004,-0.119783916,0.059381854,-0.05097985,0.0063706525,-0.040596697,0.03927759,0.096612506,0.019023832,-0.03973117,0.058560155,0.012976978,0.061478548,0.0012250313,-0.053733114,0.03794623,0.12776999,-0.07165859,0.045385167,0.11682371,0.039532885,0.050036795,0.030377172,0.02681255,0.067021936,0.003915741,0.063116126,-0.07532953,-0.043723878,-0.009268694,-0.008723922,-0.047887433,-0.012188461,0.011006881,0.010731773,-0.030841393,0.059436437,0.03372191,-0.105213046,-0.017989665,0.031294797,0.016381746,-2.8257676e-33,0.033456147,-0.097179174,0.07791658,-0.086870305,-0.06549139,0.08847254,-0.00012887866,-0.04573774,-0.009716595,0.085050665,0.05674966,0.0064365854,0.06780234,-0.044530567,-0.019176621,-0.008806701,0.027314268,0.041181058,-0.037774142,-0.031590007,0.08824453,0.09952316,0.03307138,0.11468867,-0.018384542,0.005166191,0.08729338,-0.022399725,-0.0028948665,0.025134286,0.005020542,0.04788661,-0.03658372,-0.00027537535,-0.0014657665,0.031206055,-0.045581337,-0.004134916,-0.02429741,0.019946137,-0.10571098,0.029763926,-0.014335978,0.00491532,0.06505132,0.0055163656,-0.09384331,-0.014893204,0.014532226,-0.030466633,0.04548134,0.0714114,-0.03974797,-0.0043160985,0.011307223,0.055268772,-0.026689544,-0.039381348,0.07162748,-0.011531403,-0.051355094,-0.0063267727,0.008606087,-0.021131828,0.033031356,0.0447685,0.0009118473,-0.029090783,0.08671766,-0.010761251,0.07916813,0.050436556,-0.026595155,0.1004793,-0.0052789645,0.04101927,0.005312786,-0.113123536,0.021452803,0.017579384,0.014304123,-0.046988633,0.014472757,-0.035634186,-0.14463153,-0.10229965,0.028753927,0.07551181,0.01187286,-0.024049811,0.029334463,0.02713139,-0.051614236,0.03612986,0.011103673,-3.42838e-08,0.011104788,-0.00787952,-0.0120924665,0.030887943,-0.0563187,-0.0005540619,-0.024901243,-0.029169522,0.044014063,-0.07012971,0.0058995886,0.057049226,-0.006030305,0.035465397,-0.028101902,0.06861423,-0.0049913,0.02095977,-0.015056706,-0.029060923,-0.0958833,-0.021479016,-0.032094873,0.016731715,0.020935286,-0.1194529,0.014779063,0.07042578,0.018017473,0.0110509815,0.0013745102,0.0028759425,-0.123988524,0.0021341601,-0.04862769,0.07915438,-0.021854272,-0.029632382,0.039554387,0.07302639,0.04424602,-0.14089395,-0.02240768,0.019988557,-0.026655033,0.010147103,-0.006122255,-0.07240427,-0.0026577683,-0.006987523,0.014908771,0.05023747,-0.023470208,-0.09888723,-0.12182864,0.015671799,-0.034055445,-0.036009863,-0.02283167,-0.11323556,0.0071728304,-0.0065741884,0.18084244,0.0045740204 +1.14.99.38,"Unlike most other sterol hydroxylases, this enzyme is not a cytochrome P-450. Instead, it uses diiron cofactors to catalyse the hydroxylation of hydrophobic substrates [1]. The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to the enzyme through interactions with clustered histidine or glutamate residues [4,5]. In cell cultures, this enzyme down-regulates cholesterol synthesis and the processing of sterol regulatory element binding proteins (SREBPs). cf. EC 1.17.99.10, cholesterol C-25 hydroxylase.",384,1.0,-0.061362013,-0.031278733,-0.066397086,-0.047594268,0.02042515,-3.9753497e-05,-0.06764552,0.05182444,-0.022172319,-0.09271274,-0.0018091045,0.015974276,-0.06576668,0.00022180736,0.0037221122,0.033031296,-0.030287674,-0.033962853,0.031244127,-0.062827006,0.01468792,-0.026786173,0.0012385973,-0.022956362,-0.0700335,0.07959366,0.10162753,0.088189594,-0.02488371,-0.035472326,-0.009646731,-0.010221365,-0.0011150937,-0.03700411,-0.067969635,0.09426761,-0.06181184,-0.07282215,0.007589525,0.03075785,0.07807295,-0.011463112,-0.024688665,0.007679302,0.023566272,-0.12223701,-0.040909093,0.041313153,-0.016040219,-0.0045835697,-0.01583939,-0.0664691,0.01666594,-0.029963113,-0.03438666,0.021527397,0.02497843,-0.062006697,-0.02833209,-0.058013186,-0.03931463,0.013448923,-0.03767361,-0.015201152,-0.054466903,-0.009075717,0.008605398,-0.073613055,0.03236882,-0.013104122,-0.092987195,-0.028094219,-0.016441131,0.04902294,-0.049833357,0.03089005,-0.031500775,-0.06508361,0.057780415,-0.04062056,0.08210533,0.010224008,-0.05116687,0.12312108,0.083714485,-0.00032402168,-0.045406573,0.03045354,-0.038420666,0.013350177,0.025762156,0.019904297,-0.017202083,0.07489586,-0.103522584,0.022206951,0.050210703,0.05539895,-0.091706716,-0.06551506,0.06309964,0.07780442,-0.038228575,-0.03015486,-0.048491992,-0.040553376,0.05584204,0.097527,-0.04400847,0.0012846243,-0.035597127,-0.0245559,0.051245753,-0.055172984,0.023595897,0.09118258,-0.018253906,-0.023842487,-0.029936854,-0.02687605,-0.0030078206,0.026663441,-0.013065973,0.027810026,-0.017096845,0.045505963,-0.072409175,2.4584638e-33,0.096829765,-0.008462464,-0.017360825,0.06711932,-0.024438156,0.04349026,-0.021382725,0.023758678,-0.024636496,-0.11039999,0.042384632,-0.04431046,-0.009734517,0.035797544,-0.06918586,-0.04190997,-0.013398483,0.06872196,0.07944194,0.0053757355,-0.023568895,0.057156302,-0.050127335,-0.07363881,-0.016329503,0.027948683,-0.08773017,0.017529378,0.011161189,0.02359637,-0.011064253,-0.048671376,-0.06847748,-0.03328932,0.07484249,0.022754291,-0.016778108,-0.02537702,-0.06523924,0.055991128,-0.021227108,-0.04736903,-0.01562765,-0.04194912,0.046104994,-0.0028437967,-0.09325164,0.07872776,-0.0029192313,0.03915824,0.052489962,0.0023452437,0.02601829,0.05319157,-0.03726554,0.05084525,0.0011916867,0.024869978,0.018302912,0.028025437,0.08263881,0.122818336,-0.06059622,0.1253737,-0.005204503,0.026391711,-0.010070853,-0.08352575,-0.034371063,0.16915825,-0.009665646,-0.0013278848,0.040305484,0.021831771,0.03356659,0.018857906,0.029778454,0.11282083,0.016627079,0.022102734,-0.0031875998,-0.030739628,-0.009383834,-0.053786907,-0.01845347,0.050199088,0.031473394,-0.014575536,-0.012649177,0.023307838,0.010190042,-0.085744955,-0.024058988,0.01698364,0.004649374,-3.7884504e-33,0.039418664,-0.09922865,0.041066147,-0.0965629,-0.091523625,0.055698693,0.06415164,-0.06649791,0.07540209,-0.041915577,0.06887246,0.028249422,0.0055898046,-0.06930485,0.022931263,0.0147266835,-0.08922743,-0.011793787,-0.018864999,-0.016631294,0.0058354237,0.07154465,0.05883526,0.17867908,-0.0049598585,-0.014507141,0.05799347,-0.02426025,0.081650436,0.021610035,0.0071898364,-0.00012874596,-0.042676922,-0.058975916,-0.1000869,0.027792744,-0.06488051,0.029838368,0.0011365522,0.0026290198,-0.061773058,0.0007890468,-0.031264875,-0.016838621,-0.0057311985,0.07353816,-0.037366115,-0.0321264,0.061634015,-0.01456267,0.005793035,0.01956434,-0.011019591,0.04969194,0.04130068,0.02404268,0.03733007,0.021489704,0.073131956,-0.08826038,-0.08010401,0.052066255,-0.0062626037,0.014253387,0.017356314,0.07961152,0.046487153,-0.021614559,0.0570881,-0.00948001,-0.01505204,0.03675745,0.05710217,0.100937,-0.00620394,0.05455565,-0.033732332,0.0059812414,-0.034413483,0.032933068,0.017860513,-0.019136285,0.008855674,-0.03418235,-0.0630596,-0.05286201,-0.052288964,0.072960965,0.05982479,0.008108193,0.04819312,-0.005095028,-0.10026629,-0.021051528,0.020956442,-4.1218897e-08,-0.025278084,-0.055492863,0.058024216,-0.05120689,-0.07167832,0.017504614,0.042933643,-0.08393677,0.094878584,0.007802598,0.03298595,0.10085563,0.0028504527,0.01843992,-0.011384546,0.0090966225,-0.00365021,-0.0019570172,0.038052965,-0.07939085,-0.05543383,-0.03744238,0.0011974869,0.037031565,0.09349042,-0.051108766,-0.014540571,0.040990755,0.053021178,-0.0028953592,0.03134295,-0.03221678,0.009508213,0.034137227,0.064725205,0.05960754,-0.016444866,-0.0599823,-0.042078514,0.068327986,-0.0080529265,-0.08426,-0.0004389259,-0.036839418,-0.013260201,0.01434541,-0.009630577,0.066767864,0.009506251,0.019052465,-0.031405307,-0.014145379,0.0067654317,-0.06753095,-0.080493875,0.0045457175,0.0032523905,-0.09546221,-0.020608,-0.08655193,0.04581902,0.03678893,0.20282269,0.017520314 +1.15.1.1,"A metalloprotein; also known as erythrocuprein, hemocuprein or cytocuprein. Enzymes from most eukaryotes contain both copper and zinc; those from mitochondria and most prokaryotes contain manganese or iron.",384,0.99999994,-0.106883354,-0.011721491,-0.08294534,0.05857699,0.05943252,0.018987073,0.08231073,0.041379996,-0.028823383,-0.041851617,-0.027302036,-0.0820593,-0.05091828,-0.002309813,-0.062144756,-0.027920516,-0.0065536727,0.07233094,-0.029394696,-0.025167983,-0.013421397,0.04650641,0.0602908,-0.0047125095,0.010658715,-0.048292395,-0.0063629393,-0.016839107,-0.056356587,0.026007134,-0.10007891,-0.041445456,0.021095246,-0.027902981,0.06770019,0.06399237,-0.020830233,-0.039777093,-0.06514753,-0.0657261,0.046723265,0.06987152,0.06079267,0.003767031,-0.020796388,0.041288164,0.092595495,-0.020228589,0.022950567,0.029584458,0.0034878976,-0.056231797,-0.060392343,0.09614664,0.03396263,0.013451754,-0.043490347,-0.10665309,0.039506163,0.000818533,-0.005469074,-0.046301965,0.03614029,0.010071062,0.02720187,-0.012274145,-0.0040528844,0.041764256,-0.045523774,-0.032146823,0.014196741,-0.017130397,-0.06534661,0.08295338,-0.023917608,0.10350153,0.087046325,-0.06337581,0.027997233,-0.013467973,-0.016881641,0.10693601,0.025365973,0.04261101,0.028322661,0.041549064,0.002764335,0.042785984,-0.12781076,-0.029509624,0.050107867,0.016174624,-0.008388165,-0.049137726,-0.089657985,0.0047209403,0.040800363,0.021654181,0.014118078,-0.0010240204,0.042221002,0.058135074,0.09144034,-0.099503934,-0.0031448046,-0.0117306905,-0.022208765,0.068893805,0.065928794,0.0067982394,-0.016909217,-0.050420735,-0.056518875,0.00078239915,0.033359144,0.000197373,0.055052362,-0.040842336,-0.014258785,0.040554196,-0.019209813,-0.015099678,0.027491162,0.011053766,-0.0018423552,-0.038293235,-0.13563097,5.654302e-33,0.03158702,-0.04169034,0.06307791,-0.014076569,0.024626134,0.018001948,-0.03428972,-0.021906689,0.037847847,-0.012034672,-0.14514999,-0.013182442,0.046807535,0.0024658993,-0.029288158,-0.07904558,-0.058153562,0.015356165,0.09286769,0.01061408,-0.005931121,0.05660468,-0.028891498,-0.039458785,0.0030442216,0.014905149,-0.04260384,-0.036723368,0.026131472,-0.017709611,0.022408394,-0.06952475,-0.04204359,0.03682747,0.090462886,-0.047346883,0.025875531,-0.021324715,0.005462513,-0.04981334,-0.06188897,0.010753425,-0.0817568,0.021056674,0.0804927,-0.12740463,-0.13645078,-0.0072172983,-0.062309165,-0.013021044,0.0663344,-0.029198982,0.09595043,-0.03215427,-0.09491153,0.02430581,-0.020052124,0.102622375,0.041441407,0.06961667,0.03710726,0.07981844,-0.041994605,0.095876314,0.03761393,0.059085615,-0.03942963,-0.06786642,-0.047729757,0.04157656,-0.04447455,-0.037770066,0.0633609,0.06067834,0.013933545,-0.031638753,-0.0383436,-0.032434203,-0.011665296,0.047303822,-0.023056732,0.01152004,-0.014889714,-0.021309674,-0.06681275,-0.015466548,-0.043989584,-0.020332532,9.8092336e-05,-0.02465454,0.055046998,0.022195479,-0.030611506,-0.019080244,-0.058721706,-7.032103e-33,0.09146438,-0.04102476,0.04926894,-0.08065878,-0.009481111,0.008434365,-0.013151411,-0.08250484,0.0218216,-0.019451413,0.10540296,-0.043947082,0.041001167,-0.03664284,0.027439447,0.004463356,-0.055601224,0.12202675,0.027211366,0.027782777,-0.1134134,-0.037238717,0.036992047,-0.02757465,0.0094665745,-0.010465346,-0.097245395,-0.0058890916,0.06791397,0.047258552,-0.07155539,0.037969314,-0.05649518,-0.057862375,-0.075146236,-0.043961886,0.0068248175,-0.040543288,0.059092164,0.02464455,0.07646503,-0.005857008,0.03096174,0.12683322,0.041704122,0.016607009,-0.08438641,0.07100369,-0.02369552,0.05355187,-0.028229903,-0.006288945,-0.030606098,-0.010526298,0.054092932,0.064964406,0.05557528,-0.0084461,0.0005120109,0.025757156,-0.027969215,-0.059798673,0.0040050726,0.07677761,0.019643363,0.097957686,0.027750159,0.051225126,-0.017765855,0.0072204433,0.13807926,0.06196348,-0.0027758612,-0.057198472,-0.01677741,-0.02506582,-0.014908904,0.019578774,-0.005250218,0.03063941,0.005855252,0.037068572,-0.006734722,0.033636883,0.019385265,-0.098704286,-0.00506409,0.1273126,-0.055786375,-0.046748564,0.001122045,-0.11790503,-0.035309102,0.10411102,-0.016371386,-3.572771e-08,0.0016334949,-0.019227356,0.016165253,-0.13420376,0.018482786,-0.015127599,0.01335886,-0.025326252,-0.0116153415,-0.0040350077,0.029720807,0.05256408,-0.0369272,-0.077622,0.007659771,0.073825195,0.03493468,0.014681084,0.035427134,0.06963574,0.021142095,0.008211086,-0.03753599,0.05822682,-0.048719537,-0.048947167,-0.014792449,0.07088004,-0.055738,-0.024021177,-0.018059647,0.0032831293,-0.021868054,-0.0304196,0.004549371,0.021731574,-0.013022107,-0.047779925,-0.023129787,-0.023938218,-0.08634606,-0.012488425,-0.008836747,-0.04461668,-0.0134998765,-0.027680848,-0.0053752554,0.047125645,0.030131828,-0.071750276,-0.030274674,-0.014185519,0.017384715,-0.06790491,-0.032136265,0.07945523,0.05186134,-0.05546269,-0.05399111,0.02770221,0.008956005,-0.014608467,0.1486733,0.022565356 +1.15.1.2,The enzyme contains non-heme 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+1.16.1.1,A dithiol 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flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +1.16.1.5,"A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin.",384,0.99999994,-0.10579549,-0.061539378,-0.07094621,-0.01856955,0.014100535,0.040167734,-0.012130559,-0.04609466,0.0038735322,-0.085618354,0.014931766,-0.03551283,0.028241925,0.04052095,-0.07195163,0.06689015,0.027201785,0.0196896,-0.072136335,0.0023452616,-0.0790457,0.0078663165,0.033300996,0.03687287,-0.014857345,0.010738852,-0.00070872856,0.043283958,-0.03489639,-0.0031872056,0.008847537,0.080761336,0.064744286,-0.004713387,-0.009874817,0.013476918,-0.02157702,-0.04008195,0.0148618985,-0.03257775,0.05983234,0.0062553086,0.05330507,0.04250231,0.06259524,0.016962336,-0.011357535,0.039252814,0.03770419,0.0638514,-0.03642407,-0.046203796,-0.11040321,0.112072796,0.052153904,0.024155827,-0.12875436,-0.0028005673,-0.0088750385,0.045930732,-0.052821085,0.008974114,0.07860809,0.045554526,0.046715952,-0.0018714338,-0.034532096,0.0296116,0.0607867,-0.07365838,0.025465857,-0.04707269,0.030173516,0.07452571,0.008552193,0.078271866,0.0092660505,-0.015238949,-0.024000354,-0.0504364,-0.017150344,-0.05054351,0.017731898,0.08579796,0.04470833,-0.08897105,-0.06990693,0.0016489843,-0.0543849,0.10462393,0.07400474,0.029058741,0.08902352,-0.028928358,-0.009494578,0.04329211,0.0024052577,-0.012228101,-0.07292524,-0.005843823,-0.038994513,-0.022766877,0.033753324,-0.034211647,0.0040802853,-0.004270843,0.005503561,0.008885687,-0.029710053,-0.047199618,0.014661429,-0.05606307,0.027300263,-0.06547927,0.0023753475,0.056116246,0.037375264,-0.020501113,-0.08618645,0.0102235265,-0.0274476,0.026268141,0.049525864,0.03316661,-0.050367348,0.024665626,-0.044136498,1.9734366e-33,0.0655049,-0.089252576,0.028138842,0.00772235,0.028636048,-0.0052529187,-0.0011564327,0.016368175,0.0076170666,-0.08032028,-0.033079144,0.03610144,0.05987533,0.011086601,-0.0080170175,-0.020538988,-0.033343393,-0.08966509,0.024259225,-0.023508472,0.058320325,0.017874971,-0.043380037,-0.0012868166,-0.061225377,0.0009423998,-0.009523674,0.0072416468,0.027154053,0.04607699,-0.07791052,-0.057416186,-0.08306569,-0.033359714,0.011974118,0.042238865,-0.040954415,-0.050810203,-0.06916477,0.073859856,-0.09060845,-0.045570094,-0.12025482,0.028381433,0.03365905,-0.036381375,-0.06434223,0.10222382,0.015643528,0.067538604,0.03687624,-0.10130318,0.07068136,0.04342633,-0.043997575,0.052077472,0.011947612,0.019805277,-0.06269816,0.02487054,-0.026910186,0.043594,-0.05608333,0.06301453,-0.062989786,0.026726969,-0.071631886,-0.058909465,-0.06365094,-0.008916391,0.031078087,0.023877688,0.08726055,0.0499568,0.07465987,-0.011445304,-0.030652376,-0.04221243,0.0019407765,0.03688966,-0.0081775775,-0.04302521,0.059792798,0.08550049,-0.08802671,0.050895195,0.042419888,-0.040717352,-0.034293063,0.00385414,0.04616191,-0.010764351,0.02447107,-0.018752847,0.0077804932,-2.6008953e-33,0.056981426,-0.072815165,0.0136095015,-0.012656893,0.0078199385,-0.0323618,0.03623587,-0.06315859,0.0520714,-0.028787348,0.033761453,-0.110153735,-0.03153911,-0.033016022,-0.052043788,0.04663787,-0.0300243,0.056664944,-0.027092643,0.06018309,-0.061470762,-0.058550064,0.062243715,0.07333198,0.0077835894,0.020637091,0.07944562,-0.0064391983,0.029377632,0.11585303,-0.108492814,0.048949465,-0.03324124,-0.06549434,-0.05329907,0.06009206,-0.030885888,-0.07463738,-0.035532415,-0.030089803,-0.006233227,0.03128796,-0.03358845,0.0454398,0.04663754,0.14706504,0.01526427,0.122971185,-0.020746099,-0.032609586,0.018074818,0.033988774,0.022060882,0.1618855,0.025612876,0.07171957,0.08743424,0.028263813,0.036458023,-0.010410485,0.0015142974,-0.08884749,-0.0055881506,-0.0513146,0.083010696,0.064722404,0.07288103,0.116714224,0.028896056,4.7586847e-05,0.08281295,-0.08994422,0.049714316,-0.018173944,-0.01100754,0.007928557,-0.04776469,0.028393237,-0.060959585,-0.0069877324,0.030021612,0.010209244,0.02343871,-0.01708888,-0.015215205,-0.023725195,-0.0049229814,0.08165096,-0.008910605,0.047837734,-0.061223354,0.024348263,-0.09737383,-0.012014597,0.05338604,-2.6458936e-08,0.052205704,-0.075457245,0.01743207,-0.025928313,0.041192304,0.08239373,-0.010812934,0.035156187,0.039674703,-0.024623957,0.026689151,0.057055455,-0.049783066,-0.0069827046,-0.015623925,-0.040495764,0.04517814,-0.0021418498,-0.014608902,0.0029169957,-0.12387645,0.0014132734,-0.040945522,-0.05053619,-0.10033223,-0.03836966,-0.051937614,0.011342206,0.044441063,-0.06286181,0.04119426,-0.01345503,0.0140522355,-0.11623853,-0.082677834,0.03844087,0.0077150227,-0.061771777,0.018865217,0.030047437,-0.12308114,0.0070594093,-0.07931669,-0.018040368,0.061883364,-0.056695845,0.06463242,0.050409388,0.019321816,-0.053112216,0.020514183,-0.019513978,-0.0048600757,-0.033528514,-0.024252832,0.02432539,0.0082060145,-0.074150175,-0.0388413,-0.09442435,-0.04598224,0.0030555057,0.06221883,0.025924297 +1.16.1.6,"The mammalian enzyme, which is cytosolic, can bind internalized cyanocobalamin and process it to cob(II)alamin by removing the upper axial ligand. The product remains bound to the protein, which, together with its interacting partner MMADHC, transfers it directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis. In addition to its decyanase function, the mammalian enzyme also catalyses an entirely different chemical reaction with alkylcobalamins, using the thiolate of glutathione for nucleophilic displacement, generating cob(I)alamin and the corresponding glutathione thioether (cf. EC 2.5.1.151, alkylcobalamin dealkylase).",384,0.99999994,-0.10865252,-0.009122492,-0.094783954,-0.062177412,-0.05223018,0.026887886,-0.06586431,0.018731143,0.021872856,-0.005854872,-0.014832468,-0.08261789,-0.0029517456,0.061435483,-0.020703249,0.0021909776,0.03646182,-0.032365605,-0.056742974,-0.090648726,-0.026841415,0.06412036,-0.06719084,0.029133966,0.010232292,-0.011655727,0.015498248,0.003921958,0.029192567,-0.014305703,-0.020756809,-0.049318913,0.020076552,-0.0019179246,-0.024236213,0.06968111,-0.05781663,-0.060461503,0.08178601,-0.032785855,0.04696266,0.06393268,-0.008475518,0.049788944,0.013236927,0.008472393,0.006506142,0.009032687,0.026021086,0.033580065,-0.01636824,0.007824466,-0.07247285,0.12703438,0.04267462,0.00011313106,-0.07236471,-0.0034326045,-0.010091145,0.033490904,0.00085176976,-0.006577901,0.0076347627,0.0045989756,0.054881014,-0.032981563,-0.0080366,-0.011497889,0.016797809,-0.0640844,0.04742019,-0.035878696,-0.014347499,-0.032524936,-0.013013272,0.06998654,-0.023164742,-0.035426468,-0.057188097,-0.02218254,0.039714355,0.029974524,0.057681967,0.047243766,0.029119728,-0.058349926,-0.060285214,0.05092577,0.018633392,0.07844458,0.076219924,0.003900407,0.03008624,-0.074066326,-0.050539676,0.0032804697,0.029883904,0.07604984,-0.0035303163,-0.01425177,0.007679122,0.056750577,-0.030873261,-0.065297976,0.009611253,0.015044511,0.057509698,0.09558777,0.0044673695,0.0061694984,-0.01943257,0.02085628,0.00851411,0.011054942,0.002252093,0.10898025,0.07526475,-0.013685326,-0.06760803,-0.006077336,0.018291237,0.03044956,0.05977593,0.044487026,-0.04086471,0.006502714,-0.057763882,3.9915314e-33,0.027278954,-0.035039626,0.0025909308,-0.008210367,0.013274906,-0.023492621,-0.115414016,0.038795408,-0.030378385,-0.03615047,-0.011593272,0.0154655855,0.029908793,-0.012134487,-0.036670674,-0.06535026,-0.051283967,-0.0682425,0.067890845,0.02650662,0.027374558,-0.0023981489,-0.03112886,0.03633158,-0.026824508,0.07020972,0.007118012,0.090418585,-0.053521167,0.012896348,-0.10145958,-0.02562513,-0.08306145,-0.07172618,0.015446415,-0.055996593,-0.08480095,-0.0015711166,0.007230965,0.033970688,-0.037939675,-0.0384261,-0.103160106,-0.00041485904,0.0353435,-0.05584943,-0.06321566,0.1085466,0.010687306,0.04333345,0.0027421336,-0.055712167,0.076742165,0.009923277,-0.07708726,0.043504406,0.028487442,-0.07744553,-0.0041029803,0.086635076,-0.003644744,0.015905537,-0.068759315,0.07901193,-0.041883122,0.022911787,-0.06956018,-0.054845896,-0.056490976,0.042623177,-0.012106291,-0.03425469,0.04288337,0.023122774,0.018401805,-0.039958604,0.001636267,-0.034212247,0.003417346,-0.016233396,0.025611363,0.027690714,-0.029240232,0.03276442,-0.05107546,0.039684467,0.045168977,-0.03811693,0.0016458816,0.016523821,-0.0045064413,0.015876258,0.0141472025,0.0017230869,0.017202843,-5.9674606e-33,0.14430603,-0.0835697,0.02148704,-0.13158612,-0.023002252,0.043401036,0.050417412,-0.0844316,0.06779848,-0.01724933,0.06770068,-0.027775235,-0.018685061,-0.012417515,-0.023059545,0.004787947,-0.025902143,0.076723106,-0.05586382,-0.07976981,0.0052839364,0.029012451,-0.0060056793,-0.019580327,0.032355748,0.0092086075,-0.03499262,0.09061483,0.04743656,0.17181762,-0.0878488,-0.024963032,-0.07654961,-0.07653537,-0.021502849,0.06692248,-0.0070220195,0.0068955706,-0.00218596,-0.02336545,-0.0034811988,0.09522431,-0.0071526933,0.09060979,0.05445758,0.15081708,-0.051287398,0.019331884,-0.05897559,-0.028263308,0.05939175,0.040012453,-0.041020907,0.03368952,0.0079296315,0.08696745,0.04973353,-0.045308504,0.047217175,-0.087329246,-0.012666626,-0.07945074,-0.019185707,-0.08785984,0.0075320206,-0.02523314,0.06774521,0.045138758,0.061758447,0.0558307,0.070844986,0.007113659,0.02934911,0.021245383,-0.02134166,0.045433052,-0.033430863,-0.024079988,-0.05660231,-0.07210256,-0.023763007,0.02771265,0.019528281,-0.06599857,-0.024195852,-0.020082371,0.033263434,0.14984971,-0.023344848,0.029844163,-0.10405897,0.0012482808,-0.036464058,0.032951217,0.04227202,-4.7815874e-08,-0.02664219,-0.11047539,-0.019843021,-0.04396789,-0.014742954,0.14162849,-0.03409989,-0.014052232,0.078876205,-0.03731655,0.0077556665,0.091216855,-0.021264462,0.07589633,-0.11375847,0.018476818,0.0041271546,-0.0026655998,0.037991617,-0.043973926,-0.07609749,-0.010649985,-0.057376493,-0.037299562,-0.04119682,-0.044729672,-0.08343305,0.082374714,-0.072358735,-0.012987981,0.04133205,0.02340858,0.01253392,-0.06760983,0.009751001,0.007827358,-0.00036366007,0.016241997,-0.0005480803,-0.046851944,-0.06415404,0.026648607,-0.09443391,0.05803651,0.02430917,-0.029991992,0.05653121,0.055977624,-0.013212649,0.04116836,0.108366445,-0.013073436,0.010460992,-0.031415444,-0.011151151,-0.013125323,-0.03936932,-0.11702936,-0.03723363,-0.04756271,0.020086769,0.03257495,0.1174019,-0.09289099 +1.16.1.7,"Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 1.16.1.9, ferric-chelate reductase (NADPH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].",384,1.0,-0.058347657,-0.0019361888,-0.11728272,0.048953306,0.12679867,0.07660776,-0.013399238,0.050930355,0.009206968,-0.027697356,-0.011945047,-0.014877284,-0.07196175,-0.038058355,-0.08716833,-0.07500722,-0.0647241,0.030659808,0.012415855,-0.023385761,0.0072814175,-0.02293233,-0.050006837,-0.06037676,-0.0024354174,0.0062714233,-0.04195537,-0.033046626,-0.061516102,-0.047264278,-0.07088375,0.024346821,0.031541392,-0.029926423,0.021472948,0.09689233,-0.009762073,-0.062906265,0.04181771,0.023691965,-0.020761168,0.0077918726,-0.04158708,-0.026220424,-0.036320973,-0.013701541,0.06055484,0.030567149,0.0004564752,-0.01562471,-0.06738192,0.05824335,-0.068817526,0.033310793,-0.015551953,0.0010027451,0.057896923,-0.03734508,0.036702286,0.022574132,0.017191922,-0.062295478,-0.039758086,0.017719045,0.018617041,-0.057042405,0.04204245,-0.033118475,0.015751787,-0.06826563,-0.012926259,0.004924298,-0.040267516,-0.031865902,0.019831486,0.059234485,0.025655463,-0.055373743,0.026710218,-0.011618508,0.024136405,0.03888033,-0.0122217415,0.04239291,0.00045016897,0.025080055,-0.0017370564,-0.08019985,-0.028795762,0.03656083,0.061103266,0.023503678,-0.0113086905,-0.008382505,-0.1236026,0.060283437,0.04876471,0.026502037,0.04667612,-0.04164464,-0.043336958,0.07105957,0.0065452736,-0.09734406,-0.024416437,0.012925587,-0.043539308,0.17886117,0.003311044,0.053733766,0.0065981452,0.039161958,-0.04743753,0.0076712784,0.016557483,0.07333661,0.13196337,-0.06604289,-0.11556912,0.028216925,0.046488255,-0.009552327,-0.0042470065,0.021256534,0.020657685,-0.005799883,-0.11956905,2.3006537e-33,0.060029913,0.040001057,-0.033032086,-0.058654044,-0.009539271,0.0065620653,-0.10859246,0.0026222633,0.019948384,0.044289242,-0.054500643,-0.043888975,0.01626805,-0.054520585,-0.060374245,-0.06467319,-0.032450654,-0.06468747,0.03727159,0.019340178,0.059322834,0.062473077,-0.006376336,-0.00014187377,0.036652084,0.002187317,-0.06870614,0.035083942,0.020519251,-0.024962544,0.069190316,-0.101878256,-0.06859873,0.0059424653,0.13175409,-0.04057031,-0.009371101,-0.020687731,-0.08745768,0.030260194,-0.01997722,0.05870333,0.0016659001,0.005476737,0.102357134,-0.109124556,-0.07379727,0.084337704,0.018835612,0.069242686,-0.018655878,0.018555854,0.091689914,-0.016856749,-0.016143387,-0.014579655,0.004407116,0.0025201526,0.003917522,0.104268104,0.05811646,0.034072667,-0.005244367,0.07244061,0.051347155,-0.039245795,-0.032462135,0.0014364015,0.05463052,0.060357943,-0.09235975,0.032467462,0.07529575,0.016097335,0.051605247,-0.05858296,-0.05758439,-0.039823744,0.027272137,-0.024823956,-0.0010005987,-0.030134253,0.037139103,-0.043279137,-0.05870245,0.007119405,-0.07537926,-0.0057301614,0.012391502,-0.08500177,0.06748166,-0.024408333,-0.048168972,-0.04136359,0.017153729,-3.288302e-33,0.055966508,-0.061046638,0.06129854,-0.056580152,-0.077271834,0.056064412,0.022687042,-0.028054385,-0.010609194,0.016453272,0.035369746,0.016919607,0.019983675,-0.051528007,-0.014803422,0.008508612,0.012155917,0.038257882,-0.031727154,0.026593283,-0.09772239,0.07434014,0.0742208,-0.0049271355,0.046194583,-0.011923281,-0.057236522,0.035895444,0.033194005,0.034222454,0.04426823,-0.027096935,-0.05547036,-0.054007374,-0.04737737,-0.024123259,-0.04318334,0.040693,0.060423046,0.05269042,0.04587858,-0.0448198,-0.0067987293,0.04445183,0.011079964,0.035052855,-0.10351728,0.050774712,0.050377257,0.055964492,0.02353439,0.0033524362,-0.04892416,0.029679317,0.09350375,-0.011881321,0.08428106,0.026705362,-0.026144786,0.06640623,-0.010116983,-0.05947229,0.050347436,0.010696982,0.11009763,0.07099568,0.028358288,0.10874858,0.058189295,0.028521657,0.073515765,0.06162981,0.023701351,-0.012611458,-0.008036852,-0.028717542,-0.011595808,-0.017745964,-0.058372818,0.038573015,0.045911364,-0.0033395027,-0.04543285,-0.06073725,0.00921203,-0.09723198,-0.014857047,0.018090706,-0.013422837,0.008660601,-0.04601062,-0.06063422,0.06180509,-0.002245832,0.023668075,-4.0816904e-08,0.0058671017,-0.010131339,0.004553423,-0.07827924,0.051996645,-0.004084624,-0.05284369,-0.045078006,-0.0064453315,0.0110529475,-0.049468264,0.13271767,0.01670197,-0.006226433,0.08722089,-0.021604754,0.011265748,0.05823702,-0.019187894,0.025622113,-0.038252484,-0.03412122,-0.15085873,0.07636907,0.06448256,-0.073138975,0.04470952,-0.041422747,0.021528816,0.00049598643,-0.00798386,-0.009660768,0.030760005,-0.022289868,-0.031098355,0.035394713,-0.013340297,-0.023614693,-0.07850247,0.05920958,-0.005155839,-0.013632252,-0.13046636,-0.0025019436,-0.03606295,0.008018549,-0.021806885,0.030955613,-0.035533827,0.054846358,0.05328686,-0.056290857,0.062249396,-0.1063498,-0.09392751,0.08146485,0.04810511,-0.04881436,0.028096145,0.0059674634,-0.04544458,0.029267848,0.12974183,-0.040553607 +1.16.1.8,"In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia.",384,0.99999994,-0.042125404,-0.04390712,-0.12254227,0.081057645,0.12945071,0.0016846699,-0.03401578,0.0656705,-0.0012780848,-0.06290073,0.007993963,-0.024983648,-0.104493104,0.011639203,-0.07754609,0.006710516,-0.08967982,-0.069409944,-0.02094023,0.023507733,-0.023472847,0.012775997,0.015365092,-0.036774144,-0.017171422,-0.051900763,0.049310513,-0.06847802,0.005442665,0.010907212,0.0563715,-0.025647836,0.041821476,0.031595144,-0.03979995,0.06528591,0.05771793,-0.050346352,-0.05220249,-0.01599478,0.04536083,-0.030451545,-0.011521242,-0.07207669,0.056199435,-0.027501725,0.004335653,0.0043250727,-0.01815981,0.108042255,-0.019228246,-0.04818805,-0.060335476,0.06959843,0.03767842,0.050951414,-0.02821342,-0.054351058,-0.05838025,0.052152723,0.03284282,-0.016117815,0.0073842704,-0.05805875,0.12685344,-0.03833589,0.0018372701,-0.08221617,0.053628292,-0.06795322,0.012521981,-0.057950087,-0.056345873,-0.013588836,0.023566624,0.05980376,-0.04177477,-0.052257888,0.090876415,-0.014702805,0.029890506,0.023618074,0.052554253,0.056337874,0.06939942,-0.0044662813,0.02555388,0.009035984,-0.06268071,0.047271077,-0.03051961,0.012211123,-0.0041514672,-0.003829577,-0.079683736,0.062198114,0.06973729,0.09991667,-0.025154842,0.03699217,-0.002998011,0.021806214,-0.03380759,-0.020618426,-0.121041164,-0.029735712,0.03855017,0.09848769,-0.012512896,-0.03926749,0.005469553,0.0010196684,-0.00036629578,-0.026746357,-0.005617928,0.06261835,0.012184052,-0.06805098,-0.017006075,0.07535508,-0.0051110117,0.07198341,0.04527149,0.121448256,0.0950644,-0.0053404826,-0.0910315,1.7856889e-33,0.04521814,0.069683,-0.013832825,-0.0041179126,-0.024490103,0.0352188,-0.07177192,0.03347551,0.004267015,-0.052697465,-0.06305997,-0.030164601,0.03692196,-0.040285554,-0.036943782,-0.06519031,-0.027306449,-0.048917882,0.07916972,-0.004148911,0.06523823,0.055291668,-0.007628029,0.04881571,0.012746167,-0.012796203,-0.12650172,0.073113054,0.04167745,0.043958973,0.0067154435,-0.0902639,-0.066575326,-0.011181556,-0.021646203,0.033462342,-0.05447928,-0.038160138,-0.06685831,0.054930907,0.04969526,-0.039976418,-0.038375515,-0.023741659,0.044502646,-0.058513347,-0.038375016,0.06435269,-0.00947921,0.017307136,-0.0034240254,-0.057510156,0.095494464,-0.017193004,-0.03734051,-0.014427668,-0.057143588,-0.013686113,0.0066985735,0.053845067,0.056128893,0.04091719,-0.043860294,0.13833529,-0.06948528,-0.02967599,-0.01952929,-0.03525243,0.01249862,0.07710286,0.017958945,-0.010576676,0.113233194,0.04401973,0.031103982,-0.052751802,-0.044925988,-0.0038216072,0.02526347,0.005393788,-0.014062511,-0.014597414,-0.05188303,-0.03946658,-0.07198955,-0.018096184,-0.047567744,-0.042202894,-0.035596814,0.010839815,0.044898067,-0.056383844,-0.04685607,-0.023483483,0.03299583,-2.177413e-33,0.011250346,-0.06705017,0.014908404,-0.09917354,-0.055061188,0.07526072,0.037604,-0.042329192,0.024220577,-0.01308423,0.091939405,-0.08700149,0.011588876,-0.038648117,0.005204588,0.02725069,-0.06734919,0.057319663,0.11524567,0.0057759825,-0.039593518,0.025351563,0.033535447,0.048104364,0.046283208,0.0064214547,-0.0058076466,0.028721683,0.096590705,0.07794528,-0.09213082,0.038137574,-0.03814218,-0.050817505,0.004224963,0.022449022,-0.015945828,-0.0029989034,0.012303402,-0.019441621,-0.008602385,0.02611708,-0.0039616544,0.09656119,0.05828184,0.108510464,-0.07641437,0.021955434,0.0125339,-0.044291873,0.02855981,-0.00217106,-0.03565261,0.026785094,0.010570523,0.069033764,0.043064233,0.06649289,0.027704246,-0.0007569707,0.003968506,-0.08020228,-0.013126567,-0.0008553208,0.030263124,-0.002120532,0.008506203,0.12277231,-0.006804709,0.031869575,0.10328252,0.020751998,0.022065556,0.030592624,-0.03518548,-0.04512346,-0.013919028,0.08359514,-0.002055218,-0.05422996,0.02020755,-0.0076540266,0.024350172,-0.0209176,-0.039113242,-0.05009633,0.06269672,0.0896883,-0.017809879,0.024370776,-0.055287343,0.026231945,-0.09004307,-0.049985938,-0.0018988102,-3.8333578e-08,0.020753607,-0.08525001,0.031129396,-0.07244025,0.07770793,0.054658886,0.012464341,-0.016261313,-0.02882111,0.045076404,-0.09237019,0.12680687,-0.0031729985,-0.0573451,0.044866107,-0.016595365,-0.007985491,0.08055988,-0.03169799,0.036967423,-0.023339346,0.051422212,-0.048794676,0.00853933,-0.048939407,-0.032413106,0.047331404,0.02364276,0.0023879888,-0.0673091,-0.00031717942,0.0039812457,0.043707494,-0.022141557,-0.1662849,0.008342582,0.01737983,-0.041928455,-0.11064347,0.03680845,-0.030382194,-0.028201828,-0.03418589,-0.034249637,0.04291268,-0.032225013,0.0155446865,0.0028546504,-0.0049440335,-0.010015669,-0.0008731965,-0.055096615,-0.042714614,-0.038433816,-0.05467653,-0.004061033,-0.029925803,-0.05700425,-0.03489264,-0.057676442,0.024908816,0.08719781,0.12596996,-0.017012313 +1.16.3.1,"The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a.",384,0.99999994,-0.070439994,-0.051101863,-0.100911915,0.05855241,0.07466895,0.011621525,-0.020320445,0.060490295,0.028050968,-0.08553784,0.017417727,-0.06316817,-0.055969648,0.036970466,-0.09973424,-0.092790514,-0.02588949,-0.0012831606,-0.043095056,-0.06541056,0.013797247,-0.022139695,0.025139045,0.0039651105,-0.005964319,0.050257128,0.0145390015,-0.010319162,-0.06035599,-0.06400766,0.034102492,-0.06309162,0.013047788,0.018031368,0.010237601,0.02910335,-0.021206452,-0.09795066,-0.049811758,-0.018040357,0.0077474797,-0.022932563,-0.012532288,-0.07442099,0.007909699,-0.04286807,0.056100123,-0.035278715,0.054998763,0.09595055,0.029308032,-0.019374337,-0.04341616,0.071473196,0.05582314,-0.0050776866,-0.021766832,-0.042694297,0.017353904,0.03743113,-0.024939222,0.025805766,-0.0012973596,0.07774732,0.026804395,-0.010124376,0.057654995,-0.049041964,-0.06992324,-0.103478946,-0.019455867,-0.020275714,0.0033579553,0.077495895,-0.028565848,0.089153245,0.060343552,-0.09391547,0.026771287,-0.018113147,-0.041274495,0.03620823,-0.033478875,0.08627397,0.03337065,0.09067885,-0.0023945547,-0.028936608,-0.03976379,0.019881027,0.008344433,0.050368235,-0.009166701,-0.014296378,-0.031191995,0.042951223,0.04491617,0.060877416,0.006677125,-0.051658083,-0.005320551,0.076767474,0.012841805,-0.06258767,-0.02477897,-0.040491555,0.023585165,0.093786374,0.024996143,0.027653677,0.07140847,0.019186534,0.0010465526,0.0063036783,0.062900454,0.0646698,0.024204003,-0.036776215,-0.10486175,0.034824375,-0.0043091294,-0.0014796336,-0.0019448644,0.03260967,-0.015707776,-0.023079248,-0.03844301,2.6316143e-33,0.07342026,0.0050199656,0.032944553,0.033972193,0.05313742,0.060923386,-0.108603425,0.05033679,0.0034282405,0.020009264,-0.07500855,0.018508658,0.03788562,0.008769165,-0.043759286,-0.06736445,0.002015922,-0.06190298,0.0641142,0.012343379,0.056149613,0.05503395,0.01303567,0.020591052,-0.01539113,0.08780087,-0.09045675,0.052089326,0.004460358,0.041190036,-0.05541279,-0.09091059,-0.06288729,-0.0656052,0.06011638,-0.011297739,0.036371026,0.016209308,-0.055914607,0.073916964,0.006320532,0.025009047,-0.04110564,-0.012583618,0.042757656,-0.12069212,-0.07995598,0.054789405,0.014707119,0.011073738,0.008538333,-0.036658373,0.13191272,-0.02641113,-0.0034381945,0.02048025,-0.08035387,-0.012112413,0.02373843,0.107108206,0.06617003,0.084301926,-0.07267655,0.06530022,0.01525622,-0.0049449895,-0.0012602779,0.032778174,-0.0066329115,0.05507795,-0.097112626,0.014620315,0.044295393,0.020353423,0.03989592,-0.01447317,-0.04504123,0.037265707,0.04515112,-0.057958525,-0.06287284,-0.007441418,0.083133526,-0.024828864,-0.02064225,0.02791066,-0.039851923,0.025578326,-0.048953816,-0.06593837,0.10940765,-0.03001002,-0.006848707,-0.10371447,-0.046470363,-3.5517e-33,0.0739115,-0.039955024,0.034583084,-0.107264765,0.0030983058,0.011452079,0.01617969,-0.021373522,0.013798155,0.023292242,0.06773644,-0.013453321,0.032307718,-0.12068117,0.0401279,0.07163957,-0.060558856,0.0883063,-0.025221717,-0.02575371,-0.056958802,0.04590559,0.048654325,-0.076747775,0.07632576,0.04147481,-0.12600072,-0.010795838,0.056828648,0.0439115,-0.07248363,-0.008017692,-0.03225013,-0.09444747,-0.02250779,-0.028039785,-0.020398233,0.018834181,0.086820714,0.037443224,0.001171168,0.025436351,-0.024504054,0.10596608,0.057117384,0.10563615,-0.078912705,0.00026630255,0.00010791883,0.0382739,0.0062778178,0.015840696,-0.07045189,0.03667976,0.048964277,-0.019285446,0.06665162,0.029477669,-0.07535949,0.041339256,-0.047247898,-0.049321946,0.052749116,0.06869729,0.043451305,0.06076739,0.0010659718,0.09641858,0.049407095,-0.006855253,0.091696344,-0.046092723,-0.010643865,-0.0773232,-0.030458428,-0.04511136,-0.04528909,0.06224093,0.01863762,0.051146768,-0.015634077,0.008372459,-0.004535304,-0.11284718,0.022072043,-0.08085102,0.012451079,0.065249905,0.025877198,-0.04481946,-0.05632252,-0.022209153,-0.008849772,0.0067052213,0.025005033,-3.73986e-08,-0.041369848,-0.023036119,0.016762752,-0.010762432,0.043729167,0.048492003,-0.028186446,0.0018715977,0.04521194,0.019883633,-0.015815224,0.11421286,-0.008204063,-0.07266691,0.01403428,0.056504674,-0.0062653148,0.008615055,0.0029555326,0.039658174,0.0063525313,-0.021616219,-0.0601638,0.062247172,-0.029140811,-0.07353549,-0.009911468,-0.027099788,-0.058132555,0.039730504,-0.073097154,0.0017636807,-0.05505953,-0.067614235,-0.045507185,-0.0145934755,0.022763778,0.00037295732,-0.03678005,0.0115701575,-0.022870574,-0.10454794,-0.05403438,-0.006036727,0.046672106,0.022800308,0.015887488,0.016465155,-0.004007441,-0.051692616,-0.037926205,-0.030652735,0.003014606,-0.045488495,-0.114617154,0.03214207,0.020618275,-0.06470623,-0.010598093,-0.10584663,0.0426061,0.028393004,0.15866491,-0.005873108 +1.16.8.1,"This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH.",384,0.99999994,-0.031820066,0.0024696167,-0.0924819,-0.083208404,0.0393952,0.026970541,-0.04804405,0.01591152,0.01877973,-0.013029173,0.011458896,0.008642286,-0.13492364,0.042832807,0.012398474,0.024716698,-0.009522909,0.03166713,0.035517126,-0.08833167,0.035422616,0.018145943,0.029780835,0.05417287,0.010180822,-0.008944354,0.026350064,-0.015077246,-0.010111504,-0.090270355,-0.007874458,-0.005676475,0.009710413,-0.037345476,-0.011470755,0.024720358,0.010564554,0.0023293658,0.0192916,0.031152006,-0.024717044,-0.0045678713,-0.0230127,0.01735394,0.0033329618,-0.029807491,-0.073346436,0.0100049535,0.02584356,0.0017373674,-0.11878145,-0.022205438,-0.054713357,0.07624004,0.06582379,-0.013101276,-0.03381523,0.008417452,-0.022007966,0.009630845,0.020092575,-0.012656242,0.0194141,0.034284342,0.04750073,-0.040105037,0.029951379,-0.077348046,0.0029153356,-0.07855561,-0.018480696,-0.09235639,0.021478182,-0.04170093,-0.024997182,0.069863215,-0.100759,-0.0243063,0.055776015,-0.0034241974,0.052601513,0.074547276,0.011933645,0.07536138,0.035696216,0.048111405,-0.051740125,-0.026177859,0.007937744,-0.009725146,0.07409868,0.04270811,-0.017605968,-0.016760664,-0.10759744,0.008778302,0.04996964,0.044693448,-0.030492911,-0.024718504,0.036049664,0.09035613,-0.048474107,-0.06417518,-0.11780086,0.03582659,0.05224253,0.10647854,0.01653875,0.03718538,-0.08053584,0.027511787,-0.027845928,0.01130818,-0.04262,0.1351838,0.049638685,0.049774364,-0.011798336,-0.07840468,0.02947417,0.040166803,0.041614138,0.0662413,-0.030787418,-0.008518808,-0.09465447,3.2541482e-33,0.07851553,0.055453323,-0.060363233,-0.06901532,-0.020950811,-0.032573733,-0.100721575,0.046959773,-0.012405466,-0.05549452,-0.039701737,-0.044532817,0.046785228,1.8804441e-05,0.014345963,-0.06465422,-0.0032378775,-0.021880694,0.0832691,-0.012193205,0.05799493,0.07903233,-0.00461485,0.10198841,0.011722809,-0.01371602,-0.036136612,0.0625512,-0.029156644,-0.010786789,0.075376794,-0.056200985,-0.049609773,-0.00012547402,0.0063771745,-0.032977037,-0.09409575,-0.0024569817,-0.06242342,0.06681358,-0.058885194,0.028244141,0.031723287,-0.0030790498,0.054550663,-0.13989595,-0.014797716,0.1382039,0.047651123,0.033591688,0.0030464027,-0.024515424,0.056185663,-0.019895371,-0.027340252,0.076209106,-0.011765276,-0.01871674,-0.007825483,0.050018035,0.008248932,-0.002473166,-0.02720012,0.09042557,-0.071335815,0.013198659,-0.05887106,-0.07165842,-0.036558777,0.085899904,-0.0323021,0.023634892,0.08138752,0.014748915,0.069844745,-0.083809115,0.022025889,-0.06832673,-0.03692278,-0.03482973,-0.02853926,-0.031198416,-0.0103615485,0.0006135578,0.047588047,0.019901497,-0.014008028,-0.019832127,-0.017913247,0.02889517,0.018765861,-0.060300596,-0.052286346,-0.019920046,0.036292396,-4.0626554e-33,0.092905656,-0.07391237,0.030829277,-0.13370796,-0.08114703,0.043507468,0.09345941,-0.12626913,0.030722274,-0.08184729,0.010361379,-0.0001627145,0.07079217,-0.014643889,0.007407586,0.013846063,-0.037714977,0.023464827,-0.0055405116,0.009175918,0.0146404505,0.09321637,0.06140632,-0.07590805,0.0661996,-0.030395502,0.008069084,0.08354408,0.067878805,0.015971296,-0.010987119,-0.03547101,-0.09126022,-0.034431454,-0.03789219,0.0654707,-0.05733045,-0.010028864,-0.040086724,0.019803783,-0.027483035,0.032464523,-0.07215598,-0.0063607576,0.02861056,0.040390853,-0.06859893,0.03652973,0.0008710529,-0.053369027,0.007907683,0.034483284,-0.0413129,-0.023336312,0.024873748,0.04623362,0.019210434,-0.03235325,-0.01603886,-0.041400325,0.010621234,-0.019586494,0.03199739,0.0002291653,0.065711245,0.014099105,0.014552083,0.08901138,0.06641454,0.0026185443,0.09917214,0.05608415,-0.004748177,0.088297464,-0.030780202,-0.10033504,-0.09026482,-0.000619776,-0.023327947,-0.011786852,0.026923629,0.038406607,-0.0037350159,-0.08059296,-0.0056493017,0.033468906,-0.000646937,0.07803219,0.00097024004,0.06439613,0.0011440101,0.04160834,-0.010091999,0.087488346,0.02257857,-3.8625824e-08,0.07304136,-0.0627397,0.058586862,-0.041246038,0.030513605,0.019781813,0.011310563,-0.015896147,0.014364981,-0.058516275,-0.042114012,0.15700889,0.035684172,0.029592946,-0.016301,-0.041116018,-0.02956661,0.03274899,-0.023086632,-0.08684256,0.0068579763,-0.02172389,-0.11360655,0.070399806,-0.0069252537,-0.033591636,-0.007231241,0.01341693,-0.019206794,-0.04013939,-0.019619811,0.0013535189,0.114281856,-0.10769604,0.029374192,0.037575036,0.016050039,0.013694119,-0.047210537,0.028096711,-0.02464019,-0.105496876,-0.06150959,0.02472483,0.080706604,-0.03250604,0.041134693,-0.010289894,0.029713161,0.013676738,0.048170835,-0.027422544,-0.013103044,-0.0016523311,-0.042171437,0.008855129,-0.04030892,-0.05920833,-0.020417891,-0.06833784,0.032913405,0.023887506,0.14997074,-0.07993914 +1.17.1.1,"The enzyme consists of two proteins. One forms an enzyme-bound adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine phosphate, in which the 3-hydroxy group has been removed. The second catalyses the reduction of this adduct by NAD(P)H and release of the CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate.",384,1.0,-0.010000841,0.014212692,-0.062782414,-0.03250539,0.03161294,0.026746625,-0.036259085,-0.00018459022,0.02593226,0.055816934,0.0060307453,0.049113974,-0.15724759,-0.008355302,-0.028582953,0.04574966,-0.10223897,0.031191017,0.030132856,-0.030853465,0.102101125,-0.0396939,0.014441987,0.0012464911,0.08846844,0.024370784,0.08348849,-0.0076889894,-0.011833922,-0.04813628,-0.049757127,-0.0570468,0.011436252,-0.022241082,0.06118671,0.11864219,-0.044792928,-0.004980984,-0.0402291,0.039467655,0.051072754,-0.010770809,-0.039712872,0.02061172,-0.07723191,-0.033976775,-0.07161279,0.090668984,0.07835869,-0.007981998,-0.014416243,-0.028207168,-0.03594031,0.02334093,-0.005425269,0.02713304,-0.010909874,0.046073873,-0.036446013,-0.005957763,0.040858462,-0.0068060146,-0.042923313,0.041888263,0.090110965,-0.05194847,0.05857471,-0.051218685,-0.038122732,-0.06208003,-0.032253195,-0.028896524,0.043951575,-0.047147308,0.006968617,0.024647813,-0.06821063,-0.0563221,0.05234003,-0.009382024,0.10803631,0.049914487,0.008885656,0.10100088,0.03190757,0.009878449,0.024965433,-0.029890765,0.005248643,-0.0055498965,-0.008069087,-0.026595768,-0.07688685,0.0060964515,-0.09829239,0.012509421,0.07013814,0.033959873,0.037475005,-0.026852356,0.04193563,0.062483452,-0.040178534,-0.11864873,-0.06055687,0.025948104,-0.027763378,0.111664556,0.009915067,0.04339868,-0.06357243,0.06681215,0.04360041,0.02006375,-0.061067626,0.14548235,0.008003534,-0.025130324,-0.04232916,-0.07935491,0.021440009,0.0083438065,0.056535948,0.018099952,-0.04572316,0.040356375,-0.05513578,1.4690344e-33,0.06278872,0.013073485,-0.023662783,0.02012313,0.022979729,0.03162328,-0.06370433,0.02989205,-0.13474357,0.06439107,-0.050773166,-0.10313787,0.03832042,0.025788542,-0.039070215,-0.009679172,-0.024369141,-0.022211509,0.07531809,0.041527577,0.033071842,0.123137474,-0.057705455,0.07696067,0.00452107,0.08450972,-0.072901525,0.05606169,0.027631322,0.009826156,-0.0012859588,-0.11175534,-0.116006985,-0.003283836,0.044847917,-0.044161294,-0.07130677,-0.029648041,-0.0056026927,0.032608014,-0.017862353,-0.013326691,0.000554058,-0.1001064,0.047276273,-0.072788455,0.014317778,0.025692383,0.026541794,0.06482485,0.07606515,-0.049659975,0.10731609,0.010174212,-0.08549978,-0.009510006,-0.023451006,-0.04357327,0.042319465,0.038613383,0.06448965,0.043418672,-0.04669427,0.03350941,0.010720031,-0.059842996,-0.026191814,-0.04120885,0.008752426,0.044222806,-0.07742682,-0.0028840695,0.013739073,-0.006995908,-0.0032472392,-0.058037356,-0.020034296,0.026663858,0.009399705,-0.005263742,-0.009372195,0.003277304,-0.007980543,-0.013062132,-0.010573135,0.028344495,-0.04852528,-0.064084016,-0.028369514,0.039317135,-0.0027308287,-0.09422995,-0.09203599,0.005621203,0.07605284,-4.3128105e-33,0.07258932,-0.062818944,0.05443956,-0.12804414,-0.05506162,0.041945707,0.087958194,-0.030807503,0.036455277,-0.08587602,0.048004843,-0.008414291,-0.01703314,-0.017490173,0.06211884,0.063664235,-0.07867224,0.029805738,-0.033367224,0.015843233,0.059888966,0.10233578,-0.0036789807,0.03173898,0.060573734,-0.050361104,0.067857094,0.07030079,0.05915232,0.034896895,-0.00028347556,-0.010874664,0.0085353125,0.0114301825,-0.032386284,0.029171454,-0.086006835,0.020174364,-0.033720523,0.04449198,-0.009543088,0.032446824,-0.027199164,0.043571893,0.080765285,0.07885441,-0.057831045,0.017991384,0.0045109387,-0.00049623224,0.0430635,-0.041251436,-0.040772013,0.03164352,0.046546616,-0.013610028,-0.00069562846,-0.032664068,0.0074984045,-0.017669166,-0.033796325,-0.038060706,0.022601737,0.04766184,0.045738656,0.037154686,0.0016084079,0.011169575,-0.0029715914,0.011175501,0.038008094,0.032119673,-0.036328226,0.018056324,-0.0056237252,-0.03964947,-0.12588958,0.03212508,-0.0070446273,-0.029278891,-0.0019068515,-0.024745554,0.0015646347,-0.08907902,0.010602065,-0.05649296,0.040919833,0.08641498,-0.06429757,0.060696013,-0.0036329206,0.061928473,-0.049555056,0.04474888,0.020863572,-4.599808e-08,0.066944405,-0.064333245,0.021793552,-0.093039244,0.01137855,0.01549138,0.036723603,0.068271734,0.010390004,-0.03542954,0.021416882,0.12361074,-0.034395456,0.018689664,0.009061671,-0.020121545,-0.09147938,0.026239863,-0.045981325,-0.042821877,-0.06106057,-0.033461332,-0.11539657,0.06088781,0.034084275,-0.027291086,0.0024861922,-0.024238816,0.015578067,-0.01757985,0.0560576,0.04015313,-0.0014364666,-0.052891977,-0.04398648,0.05213603,-0.07227738,0.004003004,-0.025164906,0.01227149,0.027686989,-0.05869753,-0.029246148,0.009662387,-0.029016212,0.028155804,-0.034540873,-0.014685232,-0.01024965,0.0858737,0.02216842,-0.039867163,-0.06257359,-0.057979256,-0.12118627,-0.006914795,-0.030295689,-0.0137515925,-0.038558856,-0.08019202,-0.015001914,-0.0021524327,0.16296491,-0.050919138 +1.17.1.2,"An iron-sulfur protein that contains either a [3Fe-4S] [6] or a [4Fe-4S] [5] cluster. This enzyme comprises a system in which ferredoxin is first reduced and subsequently reoxidized by an NAD(P)+-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and dimethylallyl diphosphate.",384,1.0,-0.05151891,-0.009953826,-0.07073844,0.022465711,0.07945886,-0.0005517943,-0.029872427,0.045877136,0.057854746,-0.024560189,0.039453447,-0.0012652109,-0.038237765,0.013250697,-0.09873575,0.066480406,-0.0281321,0.046912648,0.017506856,-0.02208978,0.05655524,0.030963467,-0.029463928,-0.08196371,0.032768458,0.02412484,0.035376135,0.031298313,-0.016734833,-0.061831784,-0.04786223,0.001912112,0.048882626,-0.10413784,0.018849645,0.15317923,0.007431399,-0.07930856,0.019848164,-0.009686586,-0.009557154,0.003931388,-0.020929689,0.0038191753,-0.061409026,-0.014316025,-0.029383576,0.044272717,0.027735218,-0.070019074,-0.083411686,-0.0057992237,-0.047986347,0.043394417,0.050845023,-0.04942405,0.00817666,-0.0007678888,-0.0071114935,-0.048578206,0.06679686,-0.050396632,0.016619978,-0.028373701,0.04602378,0.029904682,0.013406943,-0.041603424,0.02851792,-0.0658681,-0.07175361,-0.0070916037,-0.06944137,0.048810646,-0.03215872,0.05379875,0.024801088,-0.025611265,0.05662686,0.014772463,-0.0011116483,0.063886866,0.048711654,0.045094907,0.05770865,-0.025776597,-0.03455196,0.0071554463,-0.019441547,0.0482044,-0.014910644,-0.019273095,-0.04912807,-0.014920798,-0.03206621,0.059378326,0.030607361,0.00887711,0.013464024,-0.019514633,-0.02999849,0.064627886,-0.061005216,-0.095110126,-0.04181339,-0.032656223,-0.0499434,0.08715141,-0.0008464803,0.003842928,-0.01802686,-0.017900947,0.03501073,0.0052441214,0.035245344,0.08725024,0.069813564,-0.0315356,-0.07107446,0.013130628,-0.006773263,0.00013622508,0.0132175265,0.08316694,-0.020194853,-0.004950564,-0.16223727,8.759741e-34,0.059032213,0.07242049,-0.0029569769,0.023366714,-0.023409253,-0.038813736,-0.05353489,0.0015280679,-0.012490202,-0.010256942,-0.076485425,-0.1037652,0.056316435,-0.08879651,-0.042897847,-0.07117992,-0.043930225,0.027376486,0.0849069,-0.002446908,0.014693494,0.07048969,-0.01103055,-0.08163847,0.019517591,0.084306195,-0.051805448,-0.023424326,0.00978924,-0.016759526,0.03982328,-0.077162325,-0.10811708,0.00024793833,0.08697263,-0.029665874,-0.0065509356,-0.029462256,-0.05840264,0.02152053,-0.032350175,0.07216666,-0.018882075,-0.08273496,0.13869475,-0.082002155,-0.074771255,0.063545674,0.056661814,0.0618988,0.034603536,0.013769854,0.10970264,-0.053733002,-0.117207795,-0.027027823,-0.02430025,0.0006789247,0.012898987,0.10612162,0.036043625,0.05354034,-0.04470367,0.0545229,0.04278719,0.022149963,-0.07958054,-0.038663432,0.063661404,0.1419622,-0.0020827916,-0.063927405,0.06243145,-0.0021553715,-0.002786267,-0.06686976,-0.04275364,0.050237212,0.05860288,0.013311443,0.0041966992,-0.00215076,-0.05965217,-0.080167495,-0.005242933,0.022249512,-0.0066891434,-0.042630497,0.028612725,0.014530625,0.060829096,-0.06300229,-0.05477208,0.0006687546,-0.022750694,-2.2755295e-33,0.07280147,-0.07335949,0.04530654,-0.045348767,-0.04548989,0.067589685,0.041754466,-0.0050647235,0.020901104,0.044622634,0.11429876,-0.0016761555,0.027652796,-0.0145356925,0.021256292,0.05602281,0.0138672,0.052225377,0.0006456877,0.012105484,-0.025035525,0.1179031,0.008560685,0.06872382,-0.014363202,0.0065167965,0.004318149,-0.010812646,0.03325761,0.041632317,-0.005762628,0.025271185,-0.06935859,-0.06643965,-0.030294487,0.014374964,-0.13278073,0.033426445,0.034227185,0.035000887,0.010636053,0.04124502,-0.01747918,0.070210285,-0.015906772,0.01520293,-0.10173172,0.06242475,0.015390179,-0.024416102,-0.012731214,-0.018168867,-0.05509151,0.030853454,0.001657698,0.04343334,0.03593923,0.09448258,-0.0095598055,0.06014897,-0.0760511,-0.08027836,0.065044075,0.0040285205,0.10555888,0.0974599,-0.025111338,0.0045078592,-0.024340812,0.0062147845,0.03662338,0.0032706554,0.03254523,-0.048538223,-0.013402856,-0.06384137,-0.031443298,0.033435658,-0.026763076,0.007386013,-0.047303718,0.016286615,-0.025106754,-0.055826686,-0.021471387,-0.1461652,0.00074924587,0.083885446,0.037582,0.01932359,-0.018883826,0.008870915,-0.037359294,-0.020860648,0.06057008,-4.5755833e-08,-0.025083756,-0.03426866,0.07098276,0.009281826,0.017791,-0.029302172,-0.010265478,-0.0032566483,0.038105607,0.056311056,0.024353266,0.111728445,0.0063506095,-0.068772964,0.044716537,0.01764325,-0.015076481,0.0152065605,-0.005242145,-0.015422822,-0.044307552,-0.03157844,-0.07748307,0.037901413,0.10358818,-0.10585654,0.0009358439,-0.029811265,0.073458135,-0.035748538,0.0242958,0.034216747,0.0022352599,-0.036704708,-0.11371872,0.025091013,-0.06824876,-0.008336367,-0.06104763,0.028561136,-0.034233943,-0.04025695,-0.04009074,0.021813992,-0.03718657,0.07779617,-0.02309259,0.04102736,-0.039272454,0.019047376,0.011323092,-0.040585376,0.042450015,-0.09472953,-0.064421736,0.07836719,0.048846617,-0.007526475,0.05752087,0.0042545153,0.017255338,0.0062914235,0.14548092,-0.05596991 +1.17.1.3,"The enzyme catalyses the synthesis of catechin, catechin-4beta-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins. While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4-diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3,4-cis-leucopelargonidin can also act as substrates, but more slowly. NADH can replace NADPH but is oxidized more slowly.",384,1.0,-0.035374887,-0.061873827,-0.13135196,-0.014612581,0.10423131,0.07555664,-0.036994234,0.07172122,0.111270085,0.028116236,0.029990181,-0.008464409,-0.16014706,0.017836057,-0.049077787,0.007340406,-0.042468593,0.098934986,-0.023842447,-0.0050082156,0.019121883,-0.05002195,0.03916687,0.024908124,0.014941311,-0.022665588,0.0021311704,-0.021707356,0.006910232,-0.02839221,-0.01231335,-0.0120514715,-0.014729343,0.015825037,-0.027838122,0.06780827,-0.042557888,-0.097955674,0.038455497,0.058757026,0.039753012,0.006035693,-0.03450682,-0.09294667,0.015714724,-0.08429831,-0.040314037,-0.02982968,0.06649341,-0.029946975,-0.019140229,-0.0062550674,-0.04449216,0.01922299,-0.0051497305,-0.017087948,-0.048288107,0.015644087,0.0056300475,0.09729364,-0.015811464,0.016574826,-0.014348215,0.008059801,-0.00883265,-0.024255205,-0.062180758,0.018184584,0.017554358,0.029353615,-0.069064565,0.018789312,-0.013607131,-0.022234384,0.0007932031,0.068332024,-0.02170339,0.04638286,-0.048781414,-0.053057875,0.05788144,0.08060473,0.01792985,0.07122519,0.0005047364,0.041972067,-0.014942096,0.03524697,0.0070835855,0.047125116,0.07620881,0.07523558,-0.005227187,0.009473864,-0.06272823,0.0549874,0.058778472,-0.027037887,0.042594686,0.01663705,-0.0038682686,0.014683135,0.020126024,-0.13341261,-0.08334702,0.038728133,-0.015252978,0.05418208,0.055452444,-0.010852202,0.03499885,-0.056910403,-0.017402269,-0.04829992,-0.080816194,0.07570049,-0.041876733,-0.023832612,-0.025237693,0.060239576,-0.057383012,0.008899294,0.06785709,0.04638696,-0.02525933,0.038804017,-0.014455717,3.8382238e-33,0.15750256,0.011851883,-0.03959823,-0.016975865,0.039657712,0.0068387236,-0.008522112,0.05325481,-0.020574171,-0.03395265,-0.10230549,-0.014567385,0.0010840648,-0.023225578,0.0457597,-0.0744166,-0.010621343,-0.043622877,0.074337125,-0.017296055,0.072024904,-0.012718383,-0.034923725,0.03141724,0.024632081,-0.02170025,0.0009208957,0.040372744,-0.034202587,-0.015906498,0.013112874,-0.03576697,-0.039367188,0.08076869,0.038389668,-0.02640286,-0.079229064,-0.0756476,0.043058533,0.06475792,-0.046125803,-0.008314302,0.01382861,-0.016896775,0.075470015,-0.0032228662,-0.02924524,0.082969174,0.004409407,0.062125266,0.008930538,0.0032747323,0.08867455,0.04899767,-0.05041878,-0.013810681,-0.027251346,-0.047350142,0.06924525,0.03320259,-0.029912608,0.026389021,-0.062206004,0.022016168,-0.035833877,0.07541228,-0.10306346,0.008613258,0.04698674,-0.027279714,0.021582052,-0.041922558,0.0023840195,0.021166839,0.11564515,0.007104363,-0.09627527,0.027609885,-0.004497464,0.02466035,-0.014172472,0.08393184,-0.0701922,0.023636557,-0.062053718,0.062113665,-0.028628249,0.004184569,0.024874743,0.058428176,0.022533271,-0.024968266,-0.0031251437,-0.026839912,0.056653254,-3.5618305e-33,0.08920853,-0.06536426,-0.041763846,-0.04523248,-0.06965211,-0.0005615858,0.025139399,-0.08389201,-0.034672767,-0.037936557,0.048724465,-0.014050673,0.04245769,0.001589916,-0.06717663,0.002181614,-0.082466796,0.070578866,0.025668828,-0.038398158,0.0006361259,0.043335058,-0.07023426,0.043545403,0.118316315,-0.042979423,0.04892602,0.009892351,0.016204728,0.08961566,-0.0045568338,-0.028036425,-0.07164668,0.046451975,0.028613435,0.042672582,-0.035932466,-0.026506128,-0.031014735,0.052257754,-0.029441701,-0.06067093,0.014914132,0.005545721,0.047833122,0.035940226,-0.10210613,-0.00018418781,0.025834994,0.026758485,-0.016192097,0.009105706,-0.027073963,-0.0023208824,0.033566162,0.024034645,0.06681202,-0.060849395,0.029525833,-0.049594574,0.007821418,-0.10453447,0.061233487,0.039107803,0.049516562,0.099396124,0.04131791,0.039968796,0.10530059,-0.117866926,0.121616825,-0.07274453,0.094584815,0.051153876,-0.040025305,-0.018598275,0.040104996,0.0016327824,-0.0820676,-0.033603985,0.03757366,-0.051693235,0.0029980387,-0.090772144,-0.09747834,0.022319753,0.08362529,0.014267965,-0.07156029,0.060027447,0.03103875,0.046238173,0.016347788,0.074034475,0.06527886,-4.55543e-08,-0.03361403,-0.045584954,0.024393572,-0.0035240827,-0.02804822,-0.006672808,0.07422669,-0.033068974,-0.04304572,-0.06704262,-0.030791111,0.099523135,0.02372034,0.018091338,0.10130724,-0.0069215824,0.023904866,-0.0099803815,0.0021549582,0.004467532,-0.07928171,-0.011892929,-0.119415656,0.006953852,-0.028928088,-0.10281144,-0.04127224,0.046581414,0.056739464,-0.025237972,0.024768049,0.024297753,0.023783717,-0.024601866,0.010642073,0.023520326,-0.061151236,-0.08317211,-0.048495807,-0.03342562,-0.04879763,-0.036542553,-0.005500827,-0.019004649,-0.025511572,-0.0767108,0.090179965,0.062151898,-0.019390449,0.051462516,0.03789175,-0.024926692,0.009559159,-0.01794743,-0.009208408,-0.02317297,0.02170084,-0.032780893,-0.09152595,-0.018761458,-0.052742414,-0.014854468,0.16703318,-0.01858451 +1.17.1.4,"Acts on a variety of purines and aldehydes, including hypoxanthine. The mammalian enzyme can also convert all-trans retinol to all-trans-retinoate, while the substrate is bound to a retinoid-binding protein [14]. The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum centre. The mammalian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to an O2-dependent form, xanthine oxidase (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds [2,6,8,15] [which can be catalysed by EC 1.8.4.7, enzyme-thiol transhydrogenase (glutathione-disulfide) in the presence of glutathione disulfide] or limited proteolysis, which results in irreversible conversion. The conversion can also occur in vivo [2,7,15].",384,1.0,-0.013870498,-0.040052954,-0.050258532,-0.0075090043,0.06946456,0.041459113,-0.03300445,0.06347082,0.012146815,0.017395822,-0.0074071204,-0.0006724013,-0.06709233,0.031590406,-0.04932091,0.06713867,-0.014689042,0.013877372,0.019903816,-0.003817595,0.088355474,-0.055005487,-0.04070849,-0.046233863,0.024361664,0.0011703053,0.0045533795,-0.029408088,-0.038400598,-0.061214797,-0.06664147,-0.08867425,-0.05779194,-0.023562059,-0.031370237,0.11447238,-0.0044833305,-0.051833585,-0.026872758,-0.0065570674,0.028020862,-0.016768036,-0.10581309,0.053731956,0.056814782,-0.062080313,0.06113484,0.044011388,-0.033702534,0.06645272,-0.007492207,-0.016218191,-0.026276728,0.04624523,0.04419921,0.02334215,-0.020547956,0.06262304,0.010154536,0.053220425,-0.034610283,0.0037605758,0.06275469,-0.012790495,0.05643048,-0.078089096,-0.018745903,-0.055547904,-0.04580853,-0.06298294,-0.038911615,-0.030243449,0.011366482,-0.023505585,-0.0017478067,0.027152346,-0.07746869,-0.026178367,0.011163353,0.009865569,0.06519135,0.03654797,0.019849394,0.05896483,0.07167368,-0.07649133,-0.05741869,0.009421514,-0.026393756,0.07611379,-0.010610193,0.03265177,-0.012044595,0.01139042,-0.011548595,0.007156091,0.09918813,0.062313706,0.063476235,-0.06425495,-0.002931692,0.0955783,-0.03525059,-0.09462869,-0.079866044,-0.010272624,0.0061518573,0.10687191,-0.05983232,-0.014245817,-0.03412317,0.040214427,0.029943638,0.026549058,-0.0031603177,0.11123587,0.015108681,-0.057665747,-0.08446711,0.002554855,-0.04824356,0.0458772,0.046796486,0.08420354,0.02219548,-0.003010916,-0.058910366,3.9628412e-33,0.027470244,0.100821815,-0.062142327,0.0313176,-0.014717752,0.03553879,-0.051961306,0.078706235,0.0028291238,0.0047034244,-0.028346702,-0.08740863,0.015659623,-0.013889737,0.031059122,-0.052198783,0.018201904,-0.037119456,0.08893521,-0.005687742,0.025928704,0.020602798,-0.07502723,-0.00095135014,-0.053420167,0.058645505,-0.035801392,0.072039165,-0.011600235,-0.01505278,0.0050421404,-0.10643483,-0.04200159,0.02748887,2.9593004e-05,-0.03747455,-0.046439197,-0.033090457,-0.009627992,0.024441684,0.002275077,0.0017011549,0.016268238,-0.082908556,0.100120515,-0.07369642,-0.06006821,0.0064711496,0.02751663,-0.0058995937,0.02318064,-0.017903611,0.07986421,-0.012910893,-0.06539254,-0.04817875,-0.07397593,-0.030432004,0.00062487513,0.088547625,0.0047858977,0.04618507,-0.018445015,0.053917848,-0.0070118527,0.0021582204,-0.079139,-0.10792525,-0.0959588,0.09917647,-0.003264337,-0.021849902,0.075042926,-0.091132015,0.02476625,-0.017351208,-0.049494527,0.08832336,0.05575933,-0.047122873,0.047974944,0.03770955,0.02996024,-0.024109662,0.01668368,-0.032217544,0.011324144,-0.035505697,0.023953423,0.07827195,0.11559262,-0.10293493,-0.06213933,-0.051160906,0.044323623,-4.1419087e-33,0.05289602,-0.028630221,0.09953297,-0.11348501,-0.04384761,0.12760739,-0.0055013197,-0.0018977294,0.04043064,-0.0744516,0.030218573,0.002356121,0.05140134,-0.044026874,-0.046589714,-0.020735264,-0.018633083,0.07283172,-0.038325135,-0.08719436,-0.011910011,0.0830726,0.021995658,0.011535512,0.07858254,0.030114962,-0.016909564,0.037022505,0.11410596,0.06184053,-0.052983724,8.694787e-05,-0.0330597,0.034251817,0.04807358,-0.0049781846,-0.082577325,0.04218545,-0.0033807026,0.08925382,-5.1674786e-05,-0.014522418,-0.029713765,0.042004764,0.035147887,0.13459675,-0.08530935,-0.030730374,0.056170106,-0.02332555,0.072036706,0.028936855,-0.07041119,0.00984707,0.029540574,0.03618943,-0.010097738,-0.00942613,0.047032025,-0.018117188,-0.019864812,-0.083483055,0.024538612,-0.07266225,0.033653215,-0.019306798,0.008835731,0.1089794,0.006727884,0.0114414785,0.1073689,-0.033702895,-0.00743095,0.03503867,-0.0288006,-0.0013153345,0.0017631006,-0.024425022,-0.0090521695,-0.026422817,0.009248131,-0.0025378952,0.00691123,-0.040329847,0.054012097,-0.042030994,0.007676726,0.10708401,-0.005814355,-0.029355822,0.002775396,-0.03203383,-0.07575018,0.02715066,0.12059524,-5.476654e-08,-0.06592111,-0.051865246,0.044721566,-0.0046861395,-0.0018520157,0.045784265,0.03640593,0.0014336966,0.042226292,0.0050166966,-0.041190505,0.0663719,0.06235416,-0.03338288,0.027875364,0.004851101,-0.0068921875,0.032016676,0.029810129,0.017542405,-0.080264695,-0.06370259,-0.13356145,0.043749522,-0.022030508,-0.12237785,0.01391787,0.014985543,0.026426105,-0.042712003,-0.0071467566,0.018476805,0.06236424,0.025598988,-0.101513796,0.00560889,-0.017593333,0.009054446,-0.042414725,-0.025032101,-0.024617359,-0.035136964,-0.0287729,0.051729918,0.008546904,-0.0019627798,0.05144132,0.008672823,-0.013599637,-0.009050538,0.028792663,-0.03270945,0.027122092,-0.14066291,-0.06735251,0.02387894,-0.03055378,-0.025011852,-0.007634403,-0.06663591,0.04540885,0.03609333,0.1461029,-0.053372655 +1.17.1.5,"A flavoprotein containing non-heme iron. The enzyme is capable of acting on a variety of nicotinate analogues to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3-dicarboxylate, trigonelline and 6-methylnicotinate. The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.",384,1.0,-0.008128195,-0.01647766,-0.07667073,0.008639763,0.061324906,0.009910196,0.022240564,-0.0038312417,-0.0066378363,-0.08697516,-0.028253831,-0.006938615,-0.07775307,0.017586716,-0.03525912,0.025495613,0.023708897,0.024354318,-0.0053091375,0.033817146,-0.0020365433,-0.013779195,0.070508204,0.020061646,-0.029541045,0.038360063,0.024458759,0.0050785225,-0.041753657,-0.043747175,0.010330774,-0.008889425,0.022835892,-0.020903276,-0.006513158,0.020617675,-0.05945221,-0.018688519,0.0015387437,-0.01283632,0.034692645,-0.005569871,-0.053011686,-0.03869386,0.015999425,-0.024963535,0.022713497,-0.017765353,-0.0438127,0.047503136,-0.11419376,-0.042649113,-0.08878821,0.02252917,0.021267079,-0.024303535,-0.010905977,-0.011221807,0.017573543,-0.01966115,0.069232054,-0.01448449,0.062590785,0.0009505962,0.04820504,-0.10900609,0.003470991,-0.031955972,0.05190053,-0.049774222,-0.022371314,-0.046292692,-0.09243358,0.030997876,0.019485379,0.074733324,-0.014394882,-0.013668947,0.079273805,-0.0033309374,0.009724062,-0.03784482,-0.01045848,0.12551242,0.038015116,0.03865201,-0.033798553,0.045764457,0.030049294,0.007173784,0.04877135,0.05967964,-0.010515767,-0.021195885,-0.067626335,0.031608865,0.044953037,-0.0016091615,-0.040100574,0.022853885,-0.022996096,0.006357138,0.0028603172,-0.07001658,-0.12438135,-0.038353033,-0.008056885,-0.001840445,0.021047534,-0.06802264,-0.019571453,-0.03408072,0.05424533,-0.056612186,0.029103711,0.08345503,0.042284325,-0.023136329,0.01751663,0.035343505,0.06002264,0.045725588,0.066037185,0.04801005,0.027821308,0.03988213,-0.14828004,3.548956e-33,0.04481674,0.08748437,-0.0024794305,0.019932147,0.051147204,0.023074301,-0.07549808,0.006733945,-0.034330666,-0.012895366,-0.06283237,-0.03982571,0.052840393,0.009699352,0.037799794,-0.020321209,-0.04424536,-0.0031897947,0.09733483,-0.083434984,0.083037026,0.059683494,-0.048490167,0.08747113,0.026270624,0.008975856,-0.045760293,0.02279182,0.021110775,0.007834787,0.047061577,-0.032588355,-0.12084643,-0.08325395,0.063144706,0.034272052,-0.09990806,-0.05705353,-0.11885356,0.058412172,-0.0039193593,-0.0052479333,-0.0066163316,-0.004532232,0.0036349958,-0.095038064,-0.09077334,0.12205043,0.03594547,-0.009295928,0.005568972,-0.06873041,0.12188718,-0.013974727,-0.09421435,0.10117984,0.011771243,-0.0035264944,0.05871656,0.013400635,0.028372385,0.037923947,-0.05136604,0.046478845,-0.039153196,0.0053256536,-0.033777088,-0.05766549,0.045269888,0.05056706,-0.009248904,0.032103367,0.013826622,0.0034279292,0.010963893,-0.08432013,-0.094726324,-0.062061585,0.0112927705,0.050166443,-0.047132168,-0.08819101,0.027152946,-0.012378711,-0.021635596,-0.042425275,-0.042650968,-0.0029306004,0.0030598182,0.011916281,0.010102995,-0.06935325,-0.07074885,-0.029681357,0.0007350896,-3.4364784e-33,0.019617697,-0.06813568,0.05681641,-0.0033772707,0.0100686615,0.037999887,0.04849672,-0.07891569,-0.02450717,-0.0710649,0.033606447,-0.07037528,0.05924658,-0.01369012,0.033078495,0.10192037,-0.0067376886,0.006586146,0.0764001,0.019756604,-0.04274969,0.026380792,0.031921387,0.05181083,0.008290826,0.009992395,0.017860712,0.0034149047,0.056969974,0.04200489,-0.044393454,0.03098724,-0.009744008,-0.09651236,-0.03738126,0.08183344,0.011060296,-0.0048055174,0.0043308097,0.03614773,-0.023291368,0.020262351,0.024196323,0.0712382,0.06802399,0.06969234,-0.0438317,0.05991914,0.020909315,0.028435048,0.055692986,0.034456085,-0.06292851,0.040995758,0.0869046,0.028205233,-0.017541735,-0.012420157,-0.0060039493,-0.014735066,-0.05090052,-0.09527443,-0.01639747,-2.3796669e-05,0.08652323,0.089435644,-0.0015322316,0.0548674,0.053158388,-0.11142314,0.10949673,-0.039464567,0.037086222,0.02529907,-0.011826716,-0.0046274103,0.008173951,0.10575045,0.02322016,0.0012366545,0.03873535,-0.02782546,0.069777556,-0.04532985,0.026915317,-0.09841141,-0.060001325,0.061978415,0.010247969,-0.0050226934,-0.03788665,-0.046078723,0.011066135,0.030577233,0.036849134,-4.0148056e-08,0.030424938,-0.11516806,0.011462823,-0.034711108,0.091322005,0.003213929,-0.018343024,-0.031427484,-0.010790113,-0.02256642,-0.0073132333,0.09423794,-0.037622146,0.043743506,0.059302896,0.052376106,-0.009659313,0.08341915,-0.051184107,-0.013656658,-0.05532237,0.05245533,-0.10715139,0.042752642,0.015768897,-0.024666846,-0.051739514,-0.09073769,0.102702565,-0.0024412586,0.01733404,0.0372364,0.09139903,-0.07110064,-0.14581276,-0.0021866618,-0.038049143,-0.03771661,-0.03896034,0.03618719,0.012134241,-0.0454057,-0.07192106,-0.054517455,-0.01648419,-0.07154509,-0.035424393,-0.021241756,-0.038886745,-0.029938737,0.048999142,0.029630192,0.010745348,0.013335102,-0.05634282,-0.0018702721,0.067615174,-0.065542996,0.028682193,-0.10201083,0.046848923,0.0032250439,0.19751596,-0.010412822 +1.17.1.6,This enzyme is highly specific for bile-acid substrates and requires a free C-24 carboxy group and an unhindered 7alpha-hydroxy group on the B-ring of the steroid nucleus for activity. May be regulated by the ratio of NAD+ to NADH [2].,384,1.0,0.02664438,-0.07388483,-0.10074801,-0.051126253,-0.03641148,0.0945877,-0.08065163,0.012889181,-0.022893926,0.00859897,-0.0011983138,-0.04597456,-0.07878522,0.018677616,-0.013714318,0.03100074,-0.044731077,0.029221226,0.010188489,-0.0812952,0.005264082,-0.022402193,0.07778609,-0.011244874,0.011197783,0.0010838598,0.061037965,-0.0071897097,-0.009862526,-0.10382148,-0.027092302,-0.026578093,0.07547444,-0.042555645,-0.055334926,0.027161019,-0.0765297,-0.010968322,0.004423549,0.07897274,0.023804516,-0.0014491057,-0.05690077,-0.00873128,-0.026519334,-0.07325096,0.029573375,0.023115622,0.022247244,0.046054695,0.017684901,-0.050714523,0.032537155,0.027986813,0.026434505,0.06023677,-0.043468304,-0.033963934,0.00089210825,-0.031285364,0.030609801,-0.070529155,0.039768834,-0.021944895,0.019538444,-0.056193586,0.0049941055,-0.012609049,-0.009086877,-0.09700077,-0.040251646,-0.04841406,-0.033236213,0.013510271,-0.07175766,0.049619418,-0.06327603,-0.08227325,0.0540123,0.018560996,0.021479797,-0.009256405,-0.005747411,0.15109359,0.103314325,0.010512033,-0.007952926,0.045234684,-0.039974187,0.046074715,0.011236584,-0.012969175,-0.027544167,-0.061364427,-0.10006973,-0.04505319,0.061186563,0.014573043,-0.02804014,-0.0053024744,0.07355365,0.09200331,0.00988014,-0.049184207,-0.10018244,0.0150941145,0.010079478,0.06250231,-0.026739424,-0.017482026,0.015611896,0.004968104,0.04257714,-0.07432307,-0.047174763,0.14966883,-0.034723736,-0.0488243,-0.031281658,0.010587827,-0.0058555384,0.05295693,-0.010402714,0.07309076,0.02655709,0.03647948,-0.098848596,2.2431725e-34,0.031659804,0.03396616,-0.01160231,-0.014965521,-0.0074206665,0.02555044,-0.05601589,0.0064390423,-0.015918937,-0.06938582,0.033815056,-0.052561305,0.07121693,-0.017721456,0.031321473,0.00052372995,0.029236842,-0.022971788,0.054146465,-0.036503103,-0.002728615,0.022643257,-0.08809982,-0.04304242,0.021281475,-0.00433714,-0.030200735,0.064256445,0.016607448,0.014173817,-0.019933091,-0.018149113,-0.040963076,0.039141,0.091254465,-0.037925687,-0.08375874,-0.012625258,-0.009569237,0.065458834,0.05691829,-0.024311842,0.01071641,-0.03720181,0.049744055,-0.10210744,-0.022010108,0.057912182,0.09401641,0.08393387,0.07617555,-0.030695917,0.03665526,-0.04678328,0.0063688476,0.058303338,-0.041785628,-0.0054817456,0.0057111895,0.06639099,0.030223869,0.037831005,-0.099572696,0.096407115,-0.05561931,0.046395138,-0.10769556,-0.10877686,-0.07592834,0.050927028,-0.043107603,-0.012895607,0.055958815,0.011082963,-0.02981695,0.03420691,-0.02293033,0.027178103,0.0027042285,-0.08209597,-0.015327509,-0.04002945,-0.057869304,-0.015831016,-0.021219328,0.0143351555,0.0070682345,-0.051695533,-0.04579238,0.03137989,0.029164651,-0.056959905,-0.0735866,0.029017007,0.046566594,-3.404172e-33,0.03408495,-0.08612663,0.059187293,-0.11206433,0.017015152,0.15615897,0.03300768,-0.12570843,0.027038028,-0.034531336,0.01509206,0.03359225,-0.0075542033,-0.045351367,0.09613124,0.007458631,-0.032340243,0.063122615,-0.020202123,-0.059106056,0.0037718895,0.12426191,0.031910665,0.08839772,-0.0021394058,-0.030268779,-0.01580095,0.018511636,0.10296322,0.1365739,-0.08467065,-0.006201178,-0.044419013,-0.00018042294,0.0006072227,0.03531579,-0.04979622,-0.017477471,-0.012093384,0.06001105,-0.09196805,0.0121395225,-0.010388429,0.021964598,0.034369078,0.03812425,-0.0006932076,-0.003146464,0.044489726,-0.025035832,0.027913729,-0.033720657,0.0025175274,-0.004913274,-4.9264906e-07,0.09589843,-0.04493966,-0.033941515,0.07093008,-0.102917574,-0.023467502,-0.0041735615,-0.019321932,-0.006510261,0.0043343506,-0.012267472,-0.025183054,-0.013225121,0.016770111,-0.019077213,0.008663493,0.03867047,0.023261985,0.11736512,-0.01413557,-0.02425224,-0.07111936,-0.011477083,-0.010970454,-0.02526731,-0.04877119,0.026971051,-0.0010662986,-0.056640048,0.074853376,-0.049455434,-0.055804644,0.029204288,0.019694956,0.045954525,0.020027196,0.007165768,-0.10434682,0.025128068,-0.004213649,-3.844496e-08,0.09401594,-0.07001109,0.00470572,-0.0020053186,0.021624995,0.00041914225,0.008495336,-0.09564966,0.0647436,0.009128247,0.01287082,0.15972227,0.055683177,0.04643748,0.014910533,0.0291168,-0.018052373,0.02400021,-0.022738444,-0.0462624,-0.0640986,-0.04149441,-0.027461614,0.021891233,-0.015690882,-0.058815595,0.0076781544,0.10833617,-0.007715196,-0.040402867,0.10790461,-0.014015324,-0.003623712,-0.035661723,-0.023648093,0.07822557,0.008284738,0.0127546005,-0.021763852,0.084740706,-0.021631904,-0.055528615,-0.027130894,0.051741507,-0.009907069,-0.020961665,-0.022390971,0.017914394,-0.0047423914,0.02523516,-0.02266191,0.0060291197,-0.018011633,-0.025159327,-0.027555205,0.034734987,0.011772998,-0.10821171,-0.017941635,-0.051047627,0.027050098,0.08359859,0.16352333,-0.0771833 +1.17.3.1,Different from EC 1.17.3.2 xanthine oxidase; does not act on hypoxanthine.,384,1.0,0.020580148,-0.043653376,-0.027817698,-0.032996304,0.10079587,-0.013300572,-0.020344084,0.067819566,-0.017850861,-0.097158596,0.10218972,-0.029464627,-0.056052204,0.013839362,-0.010153938,0.04101968,0.060860496,-0.09594661,0.0052287113,0.012987417,0.05769781,-0.030983573,0.026068402,0.02218775,0.003583855,0.017164329,-0.059461847,0.09507392,0.022310674,-0.043800347,0.009591739,0.036941405,0.041302163,-0.058515124,-0.021203104,0.036611278,-0.033256743,-0.106057,0.027755417,0.029739698,0.08591432,-0.009658833,-0.065894395,0.037390407,0.0015282602,-0.04211728,-0.00696186,-0.028488118,-0.068733566,0.043260645,-0.0049099834,-0.06227195,-0.0020219213,0.020855475,0.0038981945,-0.04734474,-0.123095416,0.033797793,0.009572984,0.035776734,-0.015337283,0.040696446,0.05560763,0.006472791,0.05494636,-0.035111576,0.018762438,-0.12469299,-0.01312261,-0.06511351,-0.057500705,-0.09890617,0.03250949,0.05545643,0.00041620806,0.009954908,-0.003964128,-0.083976895,0.0017900481,-0.025661558,-0.03800947,-0.0071989377,-0.031246096,0.045564592,-0.0027269968,-0.03619767,0.0061003994,-0.058921564,-0.053228885,0.049357343,0.044595197,-0.018417003,0.020841327,0.03611804,0.01838315,-0.019808045,0.027791498,0.13126296,-0.02159815,-0.022954492,-0.019416053,0.11309834,-0.07890829,-0.06712628,-0.021175783,0.009998677,0.031083053,-0.00035041873,0.029545626,-0.0018110387,-0.049591467,-0.09622505,0.03900381,0.0044091917,-0.030778697,0.08656329,-0.024428654,0.019111376,-0.0102393,0.028578162,0.10098467,-0.106343545,0.04470979,-0.012053114,-0.006348365,-0.022453034,-0.09414604,1.3281814e-33,0.088331036,0.037393842,-0.00043426538,-0.04618732,0.002903717,0.04059357,-0.07473715,0.03339022,0.022819536,0.006498832,-0.07565254,-0.027363706,0.021336459,0.019980988,-0.030623319,-0.055138085,-0.07778214,-0.021966822,0.018466191,0.024656456,0.071669586,0.005271392,-0.07137417,0.026299974,-0.0072609005,-0.010106311,-0.04016262,0.056481957,0.025088258,-0.0056617917,0.0057898303,-0.032567777,-0.031389236,0.0433092,-0.09073572,0.031922065,-0.038304508,-0.094765745,0.013627244,-0.026316652,0.0033484648,0.089791276,0.04364836,-0.07141596,0.09324681,-0.055871006,-0.11658433,0.04045666,0.11898191,0.012032926,-0.0485419,-0.038273722,0.049503583,-0.043220725,0.06523307,-0.020631498,-0.070677124,0.10331469,0.011987391,0.038004477,-0.0030710117,0.057383962,0.00077602454,-0.010331165,0.021567965,0.10798421,-0.062361814,-0.09255535,-0.07634842,0.001471721,-0.02750877,0.024170069,0.07470427,0.011381602,0.058267444,-0.060935356,-0.055696096,0.039503545,0.06699406,-0.04012606,-0.02541444,-0.012007764,0.015129359,0.00071450416,-0.030888967,0.024091374,-0.027497979,0.060803287,0.04684779,0.052572638,0.072917886,-0.056909982,-0.029208342,-0.015895197,-0.04118929,-1.6010141e-33,-0.020231517,0.019620137,-0.009465101,0.019917605,0.03614897,0.09671418,-0.0030800074,0.030828403,0.030589828,-0.018893352,0.111371614,-0.04079303,-0.06437554,-0.07137239,0.04852145,0.051949237,-0.029266749,0.023959337,-0.06734058,0.06235091,-0.005157278,0.05577593,-0.04931078,0.06774247,0.07531865,0.017113077,0.01746323,-0.02054215,0.1148183,-0.03700392,-0.08920815,0.019574953,-0.0668371,-0.017922075,-0.017781628,0.007819453,-0.08765189,0.005463783,-0.035075497,-0.010864134,0.0073253065,-0.033902988,0.029638287,0.03692529,0.01974658,0.12662894,-0.026810382,-0.076070316,0.059488587,0.019086126,0.0006666572,0.033422317,-0.0283446,0.034890566,0.030274313,0.069808245,-0.014317447,0.058490183,-0.066401556,-0.025845226,0.03343762,-0.0008326198,0.031229392,-0.036891326,0.0065061636,0.032530613,-0.06834495,0.06131587,0.08224798,0.01997792,0.0733037,-0.07918276,0.021054696,-0.06669937,-0.03222957,-0.051596522,0.018684689,-0.041378267,-0.003309943,-0.050855927,0.037224133,0.08036935,0.014273134,-0.0064563034,0.0049673812,0.029800428,-0.024337819,0.05673249,-0.015173059,0.011685348,0.018406125,-0.0031133334,-0.077101484,-0.008416276,0.073949255,-2.4774497e-08,0.028646197,-0.06113172,0.08138763,-0.01884413,-0.0040428904,0.020304924,0.028865255,-0.024477178,0.020184647,0.04039461,0.033989727,0.047795977,0.058128882,-0.114437155,0.0470372,-0.09495799,-0.008543997,0.10032695,-0.021916747,0.032567453,-0.07888281,-0.021240054,-0.09413585,-0.010533387,-0.012317424,-0.0814724,0.041067738,0.06354605,-0.024593612,-0.05003719,0.021484723,0.054401074,0.093009576,-0.01135079,-0.052364923,0.02262268,-0.023867274,0.024064904,-0.037168738,0.006339129,-0.018489126,-0.11127522,-0.064958416,0.03591858,0.087188385,-0.02200509,0.056076474,-0.06310842,-0.012551327,-0.07177412,0.04347611,0.00013839845,0.043425072,-0.10406419,-0.008023387,0.10473293,-0.03305551,-0.05219762,0.018454876,-0.058209088,0.031062322,-0.061965734,0.13112073,0.027318398 +1.17.3.2,"An iron-molybdenum flavoprotein (FAD) containing [2Fe-2S] centres. Also oxidizes hypoxanthine, some other purines and pterins, and aldehydes, but is distinct from EC 1.2.3.1, aldehyde oxidase. Under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 O2.- + 2 H+. The mammalian enzyme predominantly exists as an NAD-dependent dehydrogenase (EC 1.17.1.4, xanthine dehydrogenase). During purification the enzyme is largely converted to the O2-dependent xanthine oxidase form (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds [4,5,7,10] [which can be catalysed by EC 1.8.4.7, enzyme-thiol transhydrogenase (glutathione-disulfide) in the presence of glutathione disulfide] or limited proteolysis, which results in irreversible conversion. The conversion can also occur in vivo [4,6,10].",384,0.99999994,-0.02386454,-0.071806416,-0.11143882,0.032294147,0.16893038,-0.008544746,-0.07879737,0.068664365,0.029037448,-0.05251107,0.010292921,0.056667525,-0.0683051,-0.013529624,-0.054744642,0.072234094,0.011625862,-0.01542339,-0.023738217,0.0012780381,0.0559406,-0.047349945,-0.0079755895,-0.050912194,0.0033333644,0.018854637,0.0071261986,-0.03567304,-0.048753724,-0.022632567,0.013386244,-0.060632274,0.033297017,-0.027803062,-0.047330316,0.07385965,0.023466295,-0.035575073,-0.029263731,-0.02763974,-0.003146457,-0.007873244,-0.054643612,-0.0027004112,0.021096783,-0.07838481,0.06707228,0.032416847,-0.064830065,0.098170176,-0.012026864,-0.015943082,-0.02494818,0.029847778,0.036032367,-0.010743265,-0.040314768,0.025938679,-0.046887927,0.031194223,-0.019963361,-0.015117883,0.045547634,-0.007629872,0.030900713,-0.06294643,-0.007945867,-0.05423061,-0.014546772,-0.07274022,-0.031134507,0.020452172,0.018099375,-0.0009168923,0.00039798915,0.09310941,-0.050139494,-0.020048402,0.07231009,-0.023916794,0.06160731,0.022841081,0.0653157,0.09179945,0.059281368,-0.057512496,-0.044800207,0.0027296816,-0.07084058,0.06743176,0.028740654,0.052634135,-0.029046109,0.022120232,-0.013426595,0.03233839,0.090719886,0.0684378,-0.01905182,-0.052588988,-0.07796112,0.09618333,-0.035051495,-0.063156046,-0.033703446,-0.021413006,-0.030960144,0.09753046,-0.0041723307,-0.019945413,-0.008923321,-0.0044134636,0.017345756,-0.0031384402,0.018185958,0.06702629,0.036558885,-0.03128078,-0.09893257,-0.0056934706,0.014635117,0.0737331,0.014697171,0.08059234,0.033412177,0.024641804,-0.069005184,6.779126e-33,0.07838575,0.08610982,-0.05405566,0.00075950776,0.0062842607,0.0002054228,-0.059253205,0.055602625,0.04161751,0.047630098,-0.027580079,-0.08661918,0.03858743,-0.08059314,0.049431875,-0.044951595,-0.023330795,-0.063558966,0.09895264,0.007292044,0.061213657,0.021716539,-0.059352905,0.027485382,0.013373134,0.038836356,-0.039134223,-0.0001594695,-0.027471583,0.018819893,0.011241534,-0.12480104,-0.07059761,-0.024768919,-0.025055766,-0.05513426,-0.09946058,-0.047469225,-0.02203238,0.013136273,-0.013990908,0.0070854146,-0.012377405,-0.051493812,0.06921959,-0.07557897,-0.0685574,0.08910276,0.0670891,0.03797489,0.01062501,-0.02890696,0.10678317,0.016322352,-0.07086499,-0.032350037,-0.05261473,0.004137497,0.026004497,0.115268186,0.0062595247,0.044784904,-0.02470564,0.063824184,-0.027123202,-0.038915943,-0.0692953,-0.09966893,-0.04357421,0.12626259,-0.0041702837,0.0022556337,0.08897451,-0.061306726,-0.0054901596,-0.049076818,-0.0015894581,0.030839728,0.047599506,-0.05125497,0.026879886,0.051006064,0.03338481,-0.010935811,-0.016889421,0.031556327,-0.061506506,-0.008381221,-0.0013626318,0.054766234,0.08447768,-0.0642996,-0.042104173,-0.06478028,0.018445054,-5.696084e-33,0.041233853,-0.044993006,0.05403988,-0.07976257,-0.019850228,0.1102931,-0.007970568,-0.014298045,0.03331728,-0.06254281,0.042548805,-0.0032252541,0.014860372,-0.020024288,0.017239237,0.028943148,-0.054927703,0.10600299,0.03439137,-0.05376263,0.0040159924,0.072650194,0.04850756,0.037798446,0.108786516,-0.00944022,-0.016244393,0.017994761,0.12757917,0.06733202,-0.04192645,0.0602324,-0.058904354,-0.034540158,-0.0044576116,-0.0019833012,-0.11348853,0.028642397,0.019668365,0.086884454,-0.012017048,-0.025378682,-0.017669478,0.05597382,0.06589246,0.09653925,-0.10230089,-0.013538651,0.06865447,-0.022171447,0.03700382,0.017759176,-0.07062717,0.063126735,0.068620265,0.0501234,0.018765138,0.018061187,0.02136453,0.0009361575,-0.017761458,-0.053494092,0.033155363,-0.0143275205,0.013870998,0.008255184,0.03298141,0.12147373,0.017778547,0.03621514,0.06585623,-0.04305535,-0.0070732785,0.012650328,0.020909386,0.011361345,-0.02064123,0.052885108,-0.01753997,0.012398761,-0.004229821,0.047371626,0.0364816,-0.020880083,-0.0020852226,-0.04902553,0.020160042,0.1466104,-0.019054651,-0.0044896,-0.027763212,-0.02714034,-0.061911274,-0.05260352,0.06245056,-5.417451e-08,-0.07016997,-0.0682459,0.04711875,-0.0033752392,0.011627946,0.022743175,0.04226544,0.0070179394,0.002205979,-0.0035234494,-0.007251612,0.080960184,0.02808716,-0.086320125,0.006855837,0.005297729,-0.019115327,0.03556731,0.0030079382,0.029876523,-0.06863874,-0.040889457,-0.10766269,0.050275892,-0.031827297,-0.09036152,-0.02853639,-0.062232953,0.051540364,-0.022466738,-0.0055460804,0.026354618,0.038642183,-0.020937452,-0.14374156,-0.0073253,-0.010837637,0.0037546514,-0.034842182,-0.0130128935,-0.07625016,-0.045457903,-0.014889463,0.035791416,0.051973756,0.009341846,0.05872161,-0.0033629388,-0.039881285,-0.07366915,0.015450746,-0.022922406,0.014483599,-0.093717866,-0.07320757,0.0611091,-0.03382833,-0.07874524,0.00080111675,-0.08102037,-0.0044475864,0.029785924,0.11917237,-0.027064202 +1.20.2.1,"A molybdoprotein containing iron-sulfur clusters. Isolated from alpha-proteobacteria. Unlike EC 1.20.9.1, arsenate reductase (azurin), it does not use azurin as acceptor.",384,0.99999994,-0.059624385,-0.050146844,-0.16172342,0.055305626,0.105069086,0.006687416,0.059716776,0.04873307,0.023955604,-0.1028101,0.06055097,0.033795238,0.027270451,0.05084471,-0.070380695,0.0066774543,-0.024832219,-0.0056277975,0.0012268506,0.037687995,-0.04982654,0.013951623,0.03496816,-0.04359191,-0.06742144,0.07802317,0.04196014,-0.021392133,-0.05447349,-0.08266119,0.0018163697,-0.05581051,0.107643865,-0.029261142,0.032253176,0.09214752,-0.009147474,-0.032742195,-0.040315073,-0.020203473,0.044725206,0.045876365,0.018408855,-0.032639083,-0.047671866,-0.020316925,0.02312409,0.03603892,-0.02782158,0.051009443,-0.07373712,-0.049388237,-0.0748243,0.114457384,0.026426474,0.001564434,-0.079659685,-0.014833738,-0.029095255,-0.025639374,0.05520906,0.032190327,0.073807545,-0.021825565,-0.04574608,-0.02506975,0.036718756,-0.028403716,-0.03081185,-0.051534727,-0.02271095,0.029636987,-0.018330704,0.07842559,-0.068785086,0.108838655,0.07775018,-0.052751344,0.094412655,-0.010493236,-0.052536238,-0.03973784,0.07224414,0.053288974,0.01713831,-0.011632836,-0.038173083,0.034625888,0.004599489,0.026991066,0.016985584,0.053645752,0.028598087,-0.06912207,-0.013112679,-0.06944894,0.006911754,0.070819795,-0.034845505,0.04756376,-0.050880898,0.050946746,-0.026901335,-0.11088062,-0.09081016,-0.039944742,0.0015967465,0.061250195,0.031160869,0.07326348,-0.002650101,-0.0032742457,0.031184942,-0.08515329,0.0064771688,0.008586158,0.06389718,-0.038775794,-0.09722199,-0.012261096,-0.01320623,0.016998326,0.06887405,0.030856429,-0.020162152,0.02298254,-0.11965217,2.316547e-33,0.05881022,0.05509235,0.03191475,-0.016309503,-0.028107716,0.009922609,-0.045955654,0.044055227,0.016126104,-0.10015292,-0.049306598,-0.05604779,0.06954872,-0.016326115,0.056635756,-0.06965683,-0.0063120956,-0.026591219,0.059560306,-0.03651108,0.016969146,0.07313182,-0.010211238,-0.0089008985,-0.024313012,0.03277038,-0.004372728,-0.013010643,0.027488867,0.006526678,0.048741706,-0.073251,-0.116649486,0.021507816,0.058574203,0.022202034,-0.04802283,-0.03712649,-0.015140858,-0.036268562,-0.040266126,0.004548111,0.019753866,-0.009409847,0.09632956,-0.0369407,-0.08124893,0.05712604,0.06582732,-0.05365465,-0.056092154,0.00017302512,0.0049999678,-0.020094162,-0.059125956,0.018582448,-0.04852142,0.06216595,-0.026069053,0.090337515,0.05592021,0.04927532,-0.0019345599,0.050433673,-0.056287464,0.040882614,-0.07325787,-0.041384116,0.054164503,0.059242364,0.046238236,0.028954186,0.100245446,0.053409506,-0.055803332,-0.052267797,0.026483135,-0.056096807,0.017784454,0.017348636,-0.08212455,-0.020230494,-0.010135435,-0.0009622626,-0.0706778,0.04376269,-0.007769975,-0.004680616,-0.01277035,0.0054846364,0.03724529,-0.022493273,-0.14372897,0.010032542,-0.093697265,-2.6518528e-33,0.09104144,-0.096098624,0.08026845,-0.039973233,-0.05010731,0.042276323,0.017109912,0.024214063,0.014388458,0.004016581,0.05046078,-0.036605325,0.0775464,-0.12951404,0.030374344,0.018929645,0.0494398,0.0025645974,0.0780981,0.013146013,-0.014524173,0.029917618,-0.015465716,-0.0010482336,-0.020388981,0.029583368,-0.043262836,0.025648767,0.059226844,0.029889321,-0.022377718,0.027103161,-0.070649385,-0.18201604,-0.089002915,0.038621627,-0.05466741,-0.032084595,-0.04262052,-0.080401555,0.041165076,-0.023862831,-0.02467512,0.15895897,0.055022445,0.061536912,-0.037934087,0.04023713,0.042811617,0.018607503,0.0041924315,-0.06112583,0.00082634675,0.0021028502,0.01925532,0.038901348,-0.020540647,0.050143916,-0.06607191,0.047685735,0.023246301,-0.0616134,0.009686351,-0.026214898,0.017356526,0.07238683,0.037362587,0.039296735,0.07501363,-0.031829476,0.03743511,-0.010860076,0.013344226,0.033590473,0.046330325,0.009752401,-0.07804682,0.020055814,-0.025797842,0.01886636,-0.015675405,0.019136883,-0.029731328,-0.0018356994,0.1342981,-0.00016002398,0.0024641596,0.046787392,-0.047530904,0.027903827,-0.06892833,-0.036008693,-0.01018806,0.02919366,-0.043857384,-3.390011e-08,0.006372435,-0.0844231,0.093435526,-0.08720602,0.015718091,0.04968745,-0.034945026,-0.046663284,-0.008632052,0.0016380479,0.033746943,0.06656876,-0.010208363,-0.04736077,0.026775418,0.05914943,0.00092987245,0.016322697,-0.019267341,0.008784702,-0.07698562,0.017091028,-0.07785127,0.022931352,-0.009444228,0.003260781,-0.037399635,-0.029480066,-0.07492916,-0.012200289,0.021631414,0.012292027,0.07791527,-0.017175628,-0.026918052,0.035239026,-0.019626256,-0.026391286,-0.05476902,0.014949814,0.018169504,0.00046425159,-0.022579068,0.04465927,-0.0037572505,-0.012784471,-0.080112554,0.0063147987,-0.034050267,-0.043893494,0.041204657,-0.0074165934,0.020651212,-0.0313223,-0.056428056,0.011321422,0.07200397,-0.09891416,0.051432975,0.078078985,0.047066994,-0.06395778,0.09869258,0.0072374223 +1.17.3.3,"Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid.",384,1.0,-0.07564105,-0.014020157,-0.062629506,0.02259736,0.09010765,-0.01621022,-0.01877361,-0.008207936,-0.0075595486,-0.096878015,-0.0046492233,-0.08261305,-0.02210889,0.015867751,-0.056701586,-0.044540405,-0.02277814,0.06248075,0.0021858872,-0.026678016,0.03105262,0.048044268,0.059782557,-0.057929505,-0.045246728,0.042318583,0.00019704981,-0.043556742,-0.009683941,-0.07687429,0.032103308,-0.0071251453,0.03375759,-0.07358774,0.026331237,-0.016598506,0.008871742,0.045271646,0.014520417,-0.043884523,-0.03819461,0.02389109,0.021087646,-0.046076465,0.038858972,-0.0080975555,0.054050196,-0.07426607,-0.000112648326,-0.030274998,-0.089107156,-0.022570765,-0.027213244,0.065228984,0.06181139,-0.030761182,-0.051252495,-0.019523641,0.07420591,0.030468008,0.09003051,-0.039192032,0.041255206,-0.03151123,0.05038941,-0.008038717,0.020196678,-0.097736605,-0.018778037,-0.045981325,-0.009514225,-0.0019126775,0.010796515,0.017238833,-0.0067179017,0.116524935,-0.024417588,-0.039580416,0.07737257,0.005395457,-0.009467293,0.010174131,0.061313134,0.18199316,0.0031667035,0.031374443,-0.012422341,-0.007218214,-0.033406638,0.06629626,0.07288072,0.07858707,-0.015153478,-0.045042347,-0.06311434,-0.0017227079,-0.017792283,0.063045405,-0.039861742,0.022089783,-0.045308355,0.057692185,-0.0069317585,-0.042444535,-0.14639474,-0.02797884,-0.010698934,0.06338602,0.08908966,0.03107083,0.0277923,0.0219428,-0.029297495,-0.076352105,-0.008720906,0.047479622,0.0984098,-0.01394339,-0.024846463,-0.018221827,0.0055093328,0.036353275,-0.011507859,0.018969106,-0.04204176,-0.005535383,-0.10228987,3.717643e-33,0.0027085629,0.038101774,0.016405364,0.01748028,0.013620789,-0.020320723,-0.094081804,-0.024998298,0.00090676267,-0.090885006,-0.07123059,-0.07583815,0.0055682906,-0.0038960266,0.0034125638,0.00084659667,0.0067929677,-0.06686125,0.10327302,-0.075259835,0.07451635,0.06614073,-0.013372301,0.021284433,0.04954914,-0.01923975,0.028756531,0.020096352,-0.0072407853,-0.006618806,0.06595513,-0.10536518,-0.08315784,-0.028190615,0.091052294,0.054741833,-0.063656256,0.024024814,-0.07796853,0.033838928,-0.0037186258,0.061125934,-0.0056572175,0.0045305495,0.020404326,-0.10322608,-0.073855825,0.12402233,0.08711487,0.024209945,-0.0051707397,-0.018861048,0.036835574,-0.038278032,-0.04938669,0.053747408,0.053798087,0.0018724182,0.0074719903,0.053585272,0.034722462,0.0038575367,-0.014605337,0.089933164,-0.0038719757,0.054801952,-0.07051566,-0.03450386,0.04514091,0.0012914926,-0.084459946,0.06709355,0.12122603,-0.02797971,-0.046218026,-0.07062704,-0.044652555,-0.08813249,0.005894558,0.050786145,0.017130375,-0.10356127,0.01799937,-0.051320847,-0.029909076,-0.027664408,-0.05507621,-0.035073984,0.02463482,0.0033284226,0.013263999,-0.13232864,-0.09492712,0.030272605,-0.055846747,-3.8193464e-33,0.073421024,-0.06757911,0.1205912,-0.06709698,-0.08035348,0.04037124,0.033701587,-0.05753197,-0.0072146794,-0.0118032815,0.04577003,-0.024974294,0.12706281,0.00033785388,-0.01563446,0.07604436,0.04375406,0.040755395,0.07318504,-0.005119397,-0.037504405,0.08124208,-0.0113619985,0.019132776,0.03455184,0.061336506,-0.0137344245,0.025866885,0.048481744,0.021294216,0.00096415705,-0.005076013,-0.051996283,-0.10042185,-0.030944383,-0.012848807,0.027025776,-0.024017042,-0.0037063155,0.0040685274,-0.052979395,-0.0026945106,-0.0152997505,0.13705927,0.02827319,0.06574566,-0.033893008,0.047538295,0.0011098054,-0.010925322,0.0601969,-0.010474711,-0.07816321,0.021210419,0.06680516,0.0322307,-0.011110159,0.080713116,-0.032350127,-0.014158112,0.0095799705,-0.06019576,0.0010516166,-0.011542594,0.046982303,0.08301138,-0.03820873,0.06644776,0.023277108,-0.065184906,0.031181782,0.03433753,0.05490205,0.009108432,-0.04420193,0.0030426297,0.026843628,0.017079217,0.0021193721,0.02814907,-0.001163963,0.031758264,-0.030516714,-0.020689242,0.047520168,-0.038285106,0.012485487,0.06312954,-0.012171831,-0.060687486,-0.08213247,0.0022917206,0.010873805,-0.0063207042,-0.0035188494,-3.6187444e-08,-0.011846794,-0.13365561,-0.019238764,-0.00019218016,0.02608229,0.044936538,0.021055186,0.010093652,-0.018928165,0.0017264829,-0.01684162,0.13789116,-0.060002554,-0.027067864,0.023703814,0.028337443,-0.010003245,0.030437617,-0.0016477901,-0.028580531,-0.054955453,0.028626487,-0.061755892,0.013919747,-0.0064654797,-0.111491926,0.011636443,-0.07241992,0.008724351,-0.016885264,4.9956554e-05,-0.04880361,0.061301913,-0.09696843,-0.05040139,-0.011526395,-0.049249716,-0.02943749,-0.011049036,0.009354756,0.016759321,0.058993258,-0.056616783,0.00031782876,-0.025367154,-0.04694002,-0.09295603,0.092602246,-0.05640301,-0.01660399,0.053003263,-0.026754571,0.017509844,-0.02238028,-0.10146506,0.058313508,0.09135676,-0.031592004,-0.0025323876,0.046584535,0.03453593,-0.04198985,0.121856555,-0.008957521 +1.17.4.1,"This enzyme is responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. There are three types of this enzyme differing in their cofactors. Class Ia enzymes contain a diiron(III)-tyrosyl radical, class Ib enzymes contain a dimanganese-tyrosyl radical, and class II enzymes contain adenosylcobalamin. In all cases the cofactors are involved in generation of a transient thiyl (sulfanyl) radical on a cysteine residue, which attacks the substrate, forming a ribonucleotide 3'-radical, followed by water loss to form a ketyl (alpha-oxoalkyl) radical. The ketyl radical is reduced to 3'-keto-deoxynucleotide concomitant with formation of a disulfide anion radical between two cysteine residues. A proton-coupled electron-transfer from the disulfide radical to the substrate generates a 3'-deoxynucleotide radical, and the final product is formed when the hydrogen atom that was initially removed from the 3'-position of the nucleotide by the thiyl radical is returned to the same position. The disulfide bridge is reduced by the action of thioredoxin. cf. EC 1.1.98.6, ribonucleoside-triphosphate reductase (formate) and EC 1.17.4.2, ribonucleoside-triphosphate reductase (thioredoxin).",384,1.0,-0.08641769,-0.05888752,-0.041946307,-0.041294318,0.040195514,-0.043272983,-0.0945465,0.033682488,0.024025029,0.045932483,0.050367832,0.024785323,-0.04960184,0.058144163,-0.015748313,0.09037098,-0.130971,0.04789221,-0.06552981,-0.03283257,0.041728273,0.038951833,-0.025370374,0.0018343966,0.01020846,0.053729516,0.12442494,0.05058926,-0.04525318,-0.07105129,-0.018139143,0.0009949747,0.028264,-0.03321603,0.04309374,0.10975598,-0.030400665,-0.031941958,0.05554873,0.0063631674,0.037929907,0.016235726,0.010330056,0.034364574,0.0342327,-0.070879646,-0.0017927185,0.0700842,0.021525245,0.0069774063,-0.027750358,0.0007220025,-0.0034928373,0.027412051,-0.01096246,0.029571924,-0.029640514,0.087312125,-0.01092461,0.04393719,0.042492416,-0.0064356877,-0.0792757,-0.0646179,0.034634467,-0.012679495,0.059613056,-0.06580253,0.0503228,-0.035968218,-0.085644566,-0.04671805,-0.039245922,0.06213088,-0.033948794,0.026762439,0.02784141,-0.021716027,0.011916037,-0.0031006793,0.045019872,0.014753205,0.067690976,0.021756582,0.1047801,0.01444492,0.004654165,0.0033055958,0.019666608,0.035550527,-0.020879913,-0.028497469,0.025288025,-0.052386414,0.021364123,0.06754401,0.030020714,0.09220444,-0.017133307,-0.0006571306,0.028524887,0.026043467,-0.08652472,-0.07635252,-0.034791943,-0.007370623,0.027288547,0.08240265,-0.006637848,0.07248386,0.003974144,0.05335392,-0.009747028,-0.026002187,-0.011842215,0.14566022,0.03800641,-0.05284838,-0.0059784027,0.028662905,0.036749937,-0.008424429,0.045020368,0.05733628,-0.049719226,0.024637217,-0.10803556,4.7326336e-33,0.05860223,0.07024736,-0.03121447,0.05405361,-0.039671663,-0.059525482,-0.09584929,0.0018238099,-0.03953497,0.020979099,-0.03274465,-0.057551056,0.09053134,-0.008938899,-0.07274122,-0.07631691,-0.053226225,0.027518075,-0.0029576963,0.05608809,-0.0082049,0.02353681,-0.04256531,-0.009023842,-0.0065466315,0.07967676,0.01339053,0.02235785,0.061751027,0.0039145076,0.03189279,-0.10183641,-0.07247266,-0.013929063,-0.0075425357,-0.028597092,-0.05212256,-0.05009661,0.034741364,0.031166973,-0.09210669,0.020761887,0.008226288,-0.0415715,0.06889575,-0.09665446,0.007555025,0.05076572,-0.016059225,-0.024580417,0.06492857,-0.051678758,0.08374084,-0.04045357,-0.011897286,-0.059961185,0.038505055,-0.008099096,0.051765256,0.111664884,0.038567733,0.0067362413,-0.074636616,0.08398313,-0.029938156,-0.04397623,-0.11405836,-0.07217439,0.027702497,0.088457294,0.015276532,-0.06735593,0.002539772,0.02176206,-0.0077078133,-0.03101958,-0.022815112,0.087294966,-0.0028260313,0.02853868,-0.026131896,-0.048260078,-0.028946849,-0.032473437,-0.09251514,0.02601006,-0.0066605574,-0.049862828,0.007560548,0.009108297,-0.008639379,-0.02607264,-0.022481155,-0.033124615,0.09081961,-6.423153e-33,0.08436681,-0.07274145,-0.07508483,-0.13309066,-0.067535155,0.104875006,0.050766844,-0.060019687,0.052066166,-0.08484417,0.061029956,-0.0039955047,-0.0136374915,-0.07006898,-0.016034687,-0.035313822,-0.010431691,0.043321047,0.0034600897,0.019230194,0.09183078,0.12220136,0.048867054,0.016766671,-0.02771875,0.0014420237,-0.028044036,0.094772086,0.035967957,0.08913929,-0.050963197,-0.032506004,-0.015119361,0.029441755,-0.015125623,0.11028408,-0.06950828,-0.05023247,-0.049628325,0.024723208,-0.041211545,0.0501082,-0.011807556,0.095114544,-0.049635243,0.047088545,-0.04668223,0.022939766,0.05697618,-0.063904986,0.04523063,-0.0014645234,0.0011618239,0.05989008,0.0046093627,0.024229066,0.046286147,-0.050595615,-0.034425482,0.028861696,-0.1034289,-0.056339856,0.041238688,-0.07968435,0.03532537,-0.020569848,-0.06274865,0.040002897,0.04641769,-0.022730751,0.024606543,0.032129146,-0.010008529,-0.0020676476,-0.027994156,-0.04655346,-0.07044268,0.059125487,-0.023424005,-0.06939922,-0.04947107,0.01669234,-0.07367343,-0.03344076,0.039415434,-0.040190306,0.020584214,0.100720935,-0.017590132,0.005944708,0.004183116,-0.010709423,-0.052093737,0.08320613,0.027977362,-5.5967817e-08,-0.015983561,-0.06952314,0.008067665,-0.029782493,0.008631633,0.059170403,-0.022543373,0.042875897,0.05696682,-0.000702875,-0.023324445,0.13797869,0.019890672,0.028069628,0.047425732,-0.0036883964,-0.036108855,0.00071713753,-0.015485284,-0.061045073,-0.004992818,-0.06349784,-0.07605841,0.033062436,-0.012289042,-0.0050274734,0.034733675,-0.008237804,0.0034614531,0.023892982,0.028306544,0.027940318,0.0060892724,-0.09259933,-0.06780898,0.04391091,-0.02755841,0.00061861426,-0.0693816,0.03312807,-0.064836666,-0.07180869,-0.1303912,0.03414443,-0.018481001,-0.030923981,-0.0029169475,0.010199263,-0.011493527,0.023845598,0.023275971,-0.007888882,-0.0052849934,-0.04687288,-0.07397204,-0.009827185,-0.007835551,-0.09248813,0.09826694,-0.016720925,0.06625119,0.008285143,0.1131628,-0.04215374 +1.17.4.2,"The enzyme, characterized from the bacterium Lactobacillus leichmannii, is similar to class II ribonucleoside-diphosphate reductase (cf. EC 1.17.4.1). However, it is specific for the triphosphate versions of its substrates. The enzyme contains an adenosylcobalamin cofactor that is involved in generation of a transient thiyl (sulfanyl) radical on a cysteine residue. This radical attacks the substrate, forming a ribonucleotide 3'-radical, followed by water loss to form a ketyl (alpha-oxoalkyl) radical. The ketyl radical is reduced to 3'-keto-deoxynucleotide concomitant with formation of a disulfide anion radical between two cysteine residues. A proton-coupled electron-transfer from the disulfide radical to the substrate generates a 3'-deoxynucleotide radical, and the final product is formed when the hydrogen atom that was initially removed from the 3'-position of the nucleotide by the thiyl radical is returned to the same position. The disulfide bridge is reduced by the action of thioredoxin. cf. EC 1.1.98.6, ribonucleoside-triphosphate reductase (formate).",384,0.99999994,-0.062801294,-0.06806857,-0.04105407,-0.036390286,-0.002260291,-0.0066806725,-0.120392345,0.067845,0.049063142,0.034012694,0.013531678,-0.009729373,-0.02352953,0.04000932,-0.053237017,0.059158783,-0.10392764,0.07657282,-0.019996658,-8.449432e-05,0.040809754,0.00315794,-0.065139666,-0.0030013856,0.01853903,0.026211787,0.15886018,-0.023830397,-0.10344156,-0.035949085,0.0098447455,-0.06814031,0.023630494,-0.025756454,0.01253077,0.14952728,-0.0021067932,-0.079227306,0.10536042,0.015409049,0.018983105,-0.010065598,0.0063254293,0.009842159,0.03612188,0.008351502,0.006522615,0.10370368,0.023898076,-0.011556129,-0.048753675,-0.0041024745,-0.0153084695,0.02818886,0.025566615,0.020316385,-0.018554794,0.034755006,0.030820478,0.014687804,0.05363278,-0.002932883,-0.034120798,-0.028738968,0.03664449,-0.08155264,0.08728084,-0.066259794,0.024719758,-0.023405742,-0.08817651,-0.024885679,0.021105977,-0.010150962,-0.009450544,0.009189551,0.0025163945,0.0061991164,0.05686493,-0.0064059016,0.052791353,-0.022577487,0.016174765,0.09394222,0.041416045,-0.0333038,0.036277976,0.0015280682,0.030192258,0.04299092,-0.019071186,0.0041813212,-0.01730497,-0.07580561,-0.039420474,-0.010991532,-0.01449556,0.07657801,-0.02222488,-0.030592995,0.0035044134,0.047406334,-0.025960822,-0.102928504,-0.05942023,-0.020088341,0.010993878,0.106290676,0.050115667,0.05526999,-0.004497335,0.046781693,-0.033508323,-0.047749136,-0.026068373,0.12694989,0.065133065,-0.08314879,-0.07613127,0.038812004,0.055603523,-0.047921237,0.033779975,0.05888043,-0.058562044,0.00051700044,-0.071875885,2.822796e-33,0.08770724,0.007699973,0.05099811,-0.0127590485,0.023959626,-0.035036463,-0.1256316,-8.761349e-05,-0.055071827,-0.004786078,-0.021584386,-0.089629054,0.08838937,0.014332876,-0.036509555,-0.045040447,-0.043862112,0.009342286,0.015280048,0.031557057,-0.01060156,0.00773393,-0.0018279968,0.0303238,0.033703517,0.020895388,0.0075181983,-0.0033174972,0.015879603,0.0062727192,0.03366857,-0.13628905,-0.09801752,0.00976332,0.043259382,-0.020042215,-0.045593802,-0.053182434,0.01522056,0.08205827,-0.101165,-0.01275591,0.0067348466,-0.048955858,0.059865575,-0.037474323,0.0010900251,0.033301227,0.020482179,-0.020280905,0.11458155,-0.03271709,0.074106544,-0.026141219,-0.006450407,-0.01810193,-0.0023554887,0.0106218215,0.046835385,0.08656411,0.07881093,0.055187143,-0.065491386,0.04787237,-0.02853975,0.023744058,-0.06814224,-0.077175826,0.04938961,0.07097136,-0.036683545,-0.015782515,0.054848988,0.014653457,-0.03187588,0.0012504888,-0.01523251,0.078319915,0.0121561205,0.011897887,-0.03425119,-0.08669737,-0.0013661076,-0.040086716,-0.08822599,0.023434944,-0.009427793,-0.059926864,-0.03885697,-0.01950748,0.015809884,-0.089303136,-0.054889865,-0.044359148,0.070243694,-5.1336024e-33,0.084942006,-0.10068499,-0.053237375,-0.10256808,-0.04866717,0.039925132,0.030005261,-0.00030356424,0.011334569,-0.08971629,0.034491174,-0.012497846,-0.012207256,0.025688142,0.01733113,0.04123777,0.0033382452,0.06939429,-0.037649713,-0.011756621,0.1078509,0.098060586,0.067183815,-0.0070944363,0.0031715706,-0.008338429,-0.02655722,0.08304839,0.040677976,0.03708105,-0.035219286,0.001060957,0.009434243,-0.07019322,-0.03650171,0.10307016,-0.0966378,-0.031282537,0.031894695,0.041809294,0.004179318,0.038126055,0.0047985357,0.05762788,-0.018640518,0.04699712,-0.048009362,0.013338361,0.046729658,-0.11004635,0.05767341,0.023377454,0.0318143,0.03517166,0.02095816,0.060832392,0.0038448109,-0.008198327,0.02664988,-0.017632969,-0.081000164,-0.08344817,0.040350076,-0.08092802,0.039943922,0.0038301384,-0.051197674,0.017632315,0.044980217,-0.049350046,-0.0066517293,0.0018061592,0.03551916,0.07294238,-0.05348778,-0.020706262,-0.09263631,0.022325953,-0.02114222,0.010556703,-0.008142904,-0.01914947,-0.05127395,-0.033103608,0.0664949,-0.074849464,0.027487813,0.06349082,-0.044829663,-0.025407504,-0.025925305,-0.023367293,-0.04232189,0.09232965,0.04047468,-5.4671265e-08,0.06324171,-0.053481188,0.003196381,-0.028985914,0.05816033,0.07892349,0.0085687125,0.01998067,0.015775153,-0.060737226,-0.0065058563,0.11669755,0.000730939,0.01833045,0.07406762,0.030629406,-0.04321026,-0.062118057,-0.021238867,-0.024507249,-0.04007541,-0.07609893,-0.114351645,0.04537,-0.019635774,-0.008290987,0.06358514,-0.010071147,-0.03713904,-0.025610333,0.021072242,0.051915374,0.0004879907,-0.060541686,-0.094731964,0.06853851,-0.120008945,0.030107459,-0.02158276,0.07783029,-0.06543823,-0.033082668,-0.07549958,0.061664987,-0.024668816,0.0066146324,-0.002711889,0.03951517,-0.064831994,0.017565291,0.027542923,-0.004430858,-0.011893228,-0.006439199,-0.047928464,0.015338743,-0.03681429,-0.094888374,0.041461546,-0.025899023,0.042779647,0.022029249,0.12847506,0.0034527034 +1.17.4.3,"Forms, in the reverse direction, part of an alternative, nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).",384,1.0,-0.021741603,-0.026720097,-0.05657224,-0.005147734,-0.084884614,0.037504636,-0.08627942,0.02860162,0.035633367,0.025676187,0.07779599,-0.033484705,-0.0103934165,0.0012057662,-0.020944493,0.04157557,-0.033673193,0.01770399,0.085124455,-0.0066441204,0.04979495,0.11440719,0.01157407,-0.03653225,0.019453436,0.028164798,-0.00015536575,0.07657664,0.092353754,-0.03984924,-0.08201609,0.08763587,-0.053446557,-0.06373643,-0.013382562,0.029672325,-0.12126603,0.042376615,0.06533375,-0.01878838,0.059734695,-0.051694326,-0.023089426,-0.04648281,-0.010116726,-0.017343424,-0.106539845,-0.030119514,-0.0060228906,-0.029848075,-0.05331974,-0.0411454,-0.078834385,0.0650865,-0.03334447,-0.041181553,0.033652887,-0.05159282,-0.04496073,-0.03975103,0.048587214,-0.001288424,-0.019647775,0.03244292,0.006189508,0.025002586,-0.040959343,0.07129793,0.02033117,-0.02239298,-0.04080908,-0.06395744,-0.051753085,-0.007543819,-0.036114264,0.023690183,0.07260803,0.05343222,-0.0018594351,-0.03289466,0.047751896,0.0914183,0.023922946,0.13676697,0.04483847,0.012755776,-0.007975032,-0.026686536,0.045997594,0.06409488,0.018076627,0.03678274,0.037863817,-0.010741263,-0.041642167,0.04222657,0.043188516,-0.015365372,0.026017616,-0.029540166,0.01331868,-0.010576166,-0.08363784,-0.056972317,-0.024738058,-0.0036547938,-0.018164085,-0.0003923158,0.017240524,-0.013631054,-0.0058847754,-0.047869373,0.02031366,-0.0037851604,-0.06291954,0.06566685,-0.004942286,-0.06482592,0.02013254,-0.024756191,-0.037990216,-0.022402968,-0.04047608,0.045610573,-0.0302772,-0.06663884,-0.05477627,-4.420228e-34,0.11353375,0.1088985,0.023243262,-0.054027572,-0.006193121,0.02468519,-0.05908909,-0.03052803,-0.034215275,-0.0044804527,-0.054613806,-0.02336264,0.0033652391,-0.010514294,-0.057185512,-0.122854024,-0.036573887,0.112192154,0.027618691,-0.07515203,-0.0506924,0.09728628,-0.034717314,-0.06954786,0.027865632,0.059843667,-0.041897092,-0.021711253,-0.020695547,-0.018817954,0.031480763,-0.05057776,-0.05100212,-0.03871484,0.07112851,-0.012010958,-0.03514377,-0.040241838,-0.061913446,0.05619011,-0.016372604,0.01743188,-0.01914864,-0.025462843,0.0671306,-0.06252181,-0.036746614,0.012447346,0.051965706,0.005662889,-0.011827174,0.02383172,0.058280904,-0.04498845,-0.052072585,-0.011068698,-0.0402642,0.030956434,-0.07273386,0.030311482,0.04020866,0.025349401,-0.082537904,-0.0087513905,-0.10730206,0.055514175,-0.15433,-0.10104528,0.031949542,0.0057091587,-0.020187616,0.010686618,0.07977143,-0.020712268,0.098731905,0.0052715167,-0.058120657,0.004614403,0.0363631,-0.0072174715,-0.067504354,-0.013736528,-0.08086867,-0.033038393,0.03534713,-0.03495097,0.040674556,-0.030373167,0.013517971,-0.008514906,0.06854167,-0.006397729,-0.108077146,0.00452501,0.023195434,-1.4310039e-33,0.0017869594,-0.061226267,-0.02511072,-0.050670043,-0.037690688,0.03918119,0.013545914,-0.008614825,0.08107624,0.024423342,0.07295531,0.027940752,0.033972405,-0.076951206,-0.044657156,-0.023076141,0.062429316,0.122628696,-0.007729338,-0.070695095,0.01760204,0.06626206,-0.012102002,0.063356385,-0.048310556,0.019135362,0.016838057,0.01831196,0.011080402,0.10665481,0.039157305,-0.041532986,-0.033030078,0.055772863,-0.0030082127,0.07153198,-0.039477848,0.016948698,0.019848945,0.024767572,0.004280414,-0.029516328,0.05565356,0.07604163,0.037629317,0.024204213,-0.15099634,0.029624876,0.062418766,-0.059720766,0.07839234,-0.0015234706,0.005810226,0.02807372,-0.0066580353,0.030182775,-0.01437491,-0.031522635,0.078748174,-0.018322073,-0.0055574174,-0.052861825,0.027115874,-0.07352861,0.024800703,0.013772831,-0.023140047,0.028579798,0.06627565,-0.029637426,0.043928437,0.122051045,0.0035754247,-0.09146432,0.0627601,-0.062030174,-0.01019918,-0.09312269,-0.039115142,-0.02887494,-0.015832331,0.052715406,0.01490008,-0.0139726605,-0.05645774,-0.0055683623,-0.006056188,0.03926718,-0.025324697,0.07758718,-0.00849839,0.014086121,-0.010304844,0.14208741,0.08822345,-3.409704e-08,0.03098762,-0.04536504,0.05520056,-0.0017267482,0.012823171,0.050022196,0.01684218,-0.05367678,0.06597031,0.023098657,-0.012304329,0.07179586,0.0030965663,0.02333827,0.097723275,0.05740174,0.0076546073,0.0014003516,-0.04209641,-0.10757335,-0.015494719,-0.058140334,-0.086906075,0.026061287,0.052855197,-0.058004502,-0.024606135,-0.04614804,-0.0077468795,-0.05384908,0.05664529,0.027866548,-0.05947032,0.018076843,-0.07714852,0.06614004,-0.010409712,-0.030889936,-0.019347345,0.09972358,-0.015490371,-0.0053755436,-0.09338146,0.043548744,-0.017330933,0.06428178,0.0077939876,0.033824574,-0.08340258,-0.016682964,0.009099652,-0.022826767,-0.0051283375,0.005029169,-0.059045948,0.018710565,0.01330891,-0.0048240563,0.0022503496,0.0039098044,0.02849706,0.09144419,0.19779477,0.0025604651 +1.17.5.1,"The enzyme from Thauera aromatica is a membrane-bound molybdenum---iron---sulfur protein. The enzyme is specific for phenylacetyl-CoA as substrate. Phenylacetate, acetyl-CoA, benzoyl-CoA, propanoyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates. The oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen. Duroquinone, menaquinone and 2,6-dichlorophenolindophenol (DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone [1]. A second enzyme, EC 3.1.2.25, phenylacetyl-CoA hydrolase, converts the phenylglyoxylyl-CoA formed into phenylglyoxylate.",384,1.0,-0.1373502,-0.08170326,-0.09789099,-0.024094362,0.06549635,0.016220042,-0.026985077,0.05018903,0.03664728,-0.06968481,0.043001346,-0.024076946,-0.06386981,0.048702043,-0.012302691,0.101092726,-0.015690198,0.016353397,-0.04662565,-0.011451877,0.02331234,-0.016831763,-0.07403023,-0.07767188,-1.1235509e-05,0.008473661,0.067361616,0.012565012,-0.042072732,-0.0016857524,0.044821456,-0.059099544,-0.009920087,-0.050944157,0.019048642,0.06693233,-0.052780535,-0.10996568,-0.031503893,0.02413602,0.01383275,-0.040742554,-0.057461094,-0.0036642724,-0.002897712,-0.111663364,-0.032486517,0.06572926,0.035757016,-0.018975519,-0.030505328,0.034785554,-0.050199594,0.13889766,-0.056156423,0.06796734,-0.04673077,0.0048851697,-0.042195454,-0.0090652425,-0.105554685,0.013093679,0.02723414,0.004372833,0.000722052,-0.022990474,-0.03754441,-0.05017224,0.06414353,-0.040063996,-0.0805616,-0.085847504,-0.0107394075,-0.016018733,0.0028440638,0.039878193,-0.026809834,0.034552176,0.12923937,-0.059882972,-0.004002114,0.03208391,0.02867953,0.12900531,0.069367394,0.0129181035,-0.01963104,-0.02547057,0.038125254,0.037126917,0.010536428,0.026815102,-0.04986976,0.01688224,-0.065028526,0.054745425,0.10263362,0.05202832,-0.03968081,0.02641917,0.009939356,0.035585083,-0.05628848,-0.14985171,-0.08748843,0.0015604552,0.017161144,0.08275457,0.03016623,-0.018090101,-0.05071973,-0.023748718,0.030118631,-0.011734903,0.06954763,0.023914825,0.04317992,-0.041436683,-0.03193708,-0.034741018,-0.07979651,0.020815644,0.08340326,-0.018448664,0.03437615,0.035159886,-0.098545805,5.044169e-33,0.088418126,0.04246361,0.04235965,0.0079350695,-0.07976517,-0.021389904,-0.08678829,0.085545264,-0.08258941,-0.0765301,-0.01944629,-0.05789739,-0.029914068,-0.026395133,0.009239661,-0.018299049,-0.006520541,0.00961754,0.10424081,0.005833599,-0.005977582,0.03966894,-0.007899437,-0.017758612,0.02617439,0.009507281,-0.092323326,0.063463524,-0.006918525,0.021074088,0.027790025,-0.07215422,-0.074213706,-0.02008002,0.0010244058,0.030862015,-0.058064368,-0.0148077225,-0.058858298,0.013555047,0.024838833,0.008276308,-0.022472655,-0.04289324,0.062399093,-0.011729344,-0.09347443,0.060707428,0.036018454,-0.007902548,0.024395367,0.0036475218,0.09786948,-0.0026436432,-0.08973962,0.0069072265,-0.0095363725,0.025660362,0.059112154,0.00078753056,-0.009792161,0.07804321,-0.021925727,0.054677673,0.0492543,0.0125308465,-0.09558877,0.006318723,-0.02266557,0.07022501,-0.013035237,0.01190007,0.0018477464,0.04803743,0.10331247,-0.11119291,-0.024107458,0.02140525,0.10409821,0.04333141,0.014087737,-0.061080772,0.023620527,-0.045201644,-0.082843564,-0.029830009,0.009419224,-0.038016766,-0.0068335645,0.016682645,0.058124024,-0.08542819,0.009364755,-0.02472679,0.05189622,-4.6324517e-33,0.08860325,-0.116288565,0.030972917,-0.04476231,0.052890986,0.04700402,-0.00028572683,-0.010242643,0.03935874,-0.015992306,0.14538245,0.006639608,0.033558447,0.0121402275,0.023224307,0.04648843,-0.03490829,0.059353568,0.07118508,0.0003299144,0.050271127,0.02207306,0.014532696,0.04997182,0.012340616,0.019410342,-0.0015430928,-0.0031263076,0.07633253,0.069622144,-0.0044578663,0.08940729,-0.06307536,-0.006763401,-0.024232624,0.038495187,-0.10981869,0.02986329,-0.0051533026,0.027387146,0.015957212,-0.071490705,-0.025291625,0.03955289,0.027987681,0.06833789,-0.030204223,-0.03242374,-0.029694391,-0.026676249,0.0287122,0.029958932,-0.08625293,0.056155197,0.046554457,0.12659125,0.03751625,-0.056233462,0.036146037,-0.05163873,-0.06730633,-0.0050732614,-0.024895107,-0.0011183749,0.022919435,0.10074121,0.010739274,0.07340704,0.03519251,-0.096835546,0.104335375,-0.007707012,0.07810985,0.027263952,0.010807723,-0.049825717,-0.01618909,0.025311312,-0.04512573,-0.011923281,-0.0039379704,-0.010985639,-0.002997297,-0.049536042,-0.036089137,-0.07577153,0.013871249,0.00880764,-0.061863683,0.04632124,-0.022840466,0.039184604,-0.07258644,0.08089177,0.071861625,-5.434106e-08,-0.018620064,-0.042213053,0.058102127,-0.055089314,-0.0014603854,0.0156715,0.044541914,-0.041562513,0.0018722069,0.023432314,0.013917777,0.07189866,0.01847484,0.0006520861,0.051770236,0.0210014,0.0014006655,-0.008992846,-0.0110433195,-0.053912535,-0.026554298,0.011994029,-0.03072096,0.04200238,0.026846107,-0.07155302,-0.019115603,0.0010018522,0.017239718,-0.002446203,-0.013213934,0.054857437,0.006995085,0.003124692,-0.011838771,0.0038089973,-0.008098575,-0.08933682,-0.034546614,0.03631955,-0.007810854,0.0040569655,-0.040313408,0.0017537368,0.111940034,0.009585085,0.04639457,0.04643862,-0.017841546,0.015392627,-0.011938755,-0.01918964,0.025845077,-0.08386847,-0.077477865,0.071173266,-0.0008742765,-0.027826607,-0.039091118,-0.065723486,-0.043683663,-0.0024619442,0.17137855,-0.0062235147 +1.17.99.1,A flavocytochrome c (FAD). Phenazine methosulfate can act as acceptor. A quinone methide is probably formed as intermediate. The first hydroxylation forms 4-hydroxybenzyl alcohol; a second hydroxylation converts this into 4-hydroxybenzaldehyde.,384,1.0,-0.116894744,-0.076741025,-0.09606956,-0.017154116,0.0495932,0.04442036,-0.0438726,0.061698556,-0.007363432,-0.008057129,0.011380211,-0.026631584,-0.07362958,0.00021518329,-0.038263395,0.054394495,-0.069604725,0.04725686,-0.046487622,0.029660258,-0.02508912,-0.031089846,0.068015546,-0.035788085,0.037750583,0.017900812,0.0045426446,0.043406848,0.054253403,-0.021006733,0.10138318,0.0826514,0.010258278,0.01877057,-0.02843982,0.007576101,0.034132,-0.0019444833,0.03380852,0.017026944,0.0045449287,0.03474191,0.049461856,0.014206732,0.039225202,-0.027143005,-0.030306572,0.082485884,-0.03424223,-0.022011278,-0.022293871,-0.04789165,-0.12087775,0.07314301,-0.027601715,0.035633296,-0.035323396,-0.019644614,0.031824857,0.09625278,-0.018291106,-0.0053392807,-0.05662395,0.0019372278,-0.008542893,-0.03493926,-0.065406345,-0.017616322,0.109694645,-0.003485342,-0.019070432,-0.08424505,-0.009427153,-0.023303349,0.0216789,0.028336896,-0.05357945,-0.0012556749,0.047473796,-0.038470116,-0.019609978,-0.010745348,0.062148694,0.056928657,0.060064044,-0.069887966,-0.0057065263,0.01348906,0.02194238,0.03730185,-0.041273445,0.04626642,-0.038423702,-0.054087646,-0.08961224,0.08172449,0.10795993,0.035722192,0.020710448,0.04286609,-0.020588722,0.023215316,-0.005590065,-0.072440796,-0.051471245,-0.0881522,0.05364573,0.12051138,-0.02528471,-0.010253528,-0.048732758,-0.0677112,1.9243666e-06,-0.0803013,-0.055815827,0.03996358,0.02437993,-0.09105203,0.0038297116,-0.05258764,-0.06529944,0.062378656,0.07103433,-0.008390943,0.038594715,-0.010149205,-0.033705663,5.4653853e-33,0.07176827,0.033341564,-0.062333636,0.0019768665,-0.023883833,-0.017320208,-0.07989518,0.03710623,-0.024290927,-0.0416531,-0.022465933,0.017995214,-0.058222644,0.011532633,-0.026569564,0.0068014353,0.004935756,-0.06535682,0.076301165,-0.13889088,0.012899805,0.06316651,-0.003602998,-0.013255163,-0.012723253,-0.020564266,-0.043963853,0.07827559,0.04196591,0.01278666,0.039824814,-0.036434393,5.9649334e-05,-0.008089141,-0.087313555,0.117412716,-0.15937842,-0.08013842,-0.061843853,0.04213627,-0.0026669505,-0.041162238,0.017796755,0.0040963804,0.03448792,-0.03397422,-0.070723236,0.0727867,0.01886157,0.04619562,0.036010187,-0.009381808,0.08037042,0.089690246,-0.1311589,0.032197196,0.02506019,-0.029004218,0.045653068,-0.019298324,0.044810705,0.056367666,-0.013588259,0.08770819,-0.02650184,-0.029637275,-0.002509379,-0.041932497,0.0096779475,0.06321889,0.007940448,-0.07027403,0.05260064,0.025137369,0.06152354,-0.02085611,0.031924,-0.09584342,0.0038975806,-0.022589467,0.008709227,-0.033155885,-0.017825313,0.056990873,-0.060610265,-0.020976106,-0.03862999,-0.05733862,0.014542494,0.013158936,-0.027086962,-0.11239076,0.0045749196,0.016106095,0.061205737,-4.2815718e-33,0.061509397,-0.008008728,0.030049292,-0.02359755,0.0065488648,0.048230294,0.017839683,-0.10926672,0.05517714,-0.0010293593,0.075301886,-0.08578285,-0.0011853399,-0.01282794,-0.020151256,0.0025540844,0.048846535,0.020530093,0.051839203,0.060619913,-0.017543998,0.06073658,0.010631539,0.074236274,0.030886011,-0.0030994627,0.07721694,-0.037795976,0.023628287,0.06572658,-0.030527877,-0.023287455,-0.0052107116,-0.012928471,-0.044871263,0.051654387,-0.05512157,0.0057649235,-0.08287067,0.010379153,0.022520788,-0.019059239,-0.022474557,0.10572708,0.06267758,0.031660505,-0.047648348,0.032474447,-0.010104069,-0.016337583,0.053164814,0.054736868,-0.052999835,0.01566349,0.08243935,0.06925441,0.024984518,-0.056471713,-0.005092965,-0.059439823,-0.011183311,-0.11367076,0.019901972,-0.08093254,0.09503122,0.050860498,-0.027222268,0.18856508,-0.00962971,0.010260198,0.124883585,0.02990519,0.034250617,0.047816396,0.01875603,-0.049989823,0.03844764,0.022950517,-0.022073146,0.0077406093,0.0397305,-0.007579541,0.027247608,-0.018910546,-0.07276493,-0.08536588,-0.010070616,0.03514875,0.01859586,0.037659623,0.034452837,0.12671417,0.026239222,0.030351724,0.041841894,-3.6245495e-08,0.004978127,-0.020853931,0.02908675,0.03451892,0.038170163,-0.026622774,0.0006225441,-0.04005844,-0.051525954,-0.02183867,-0.07645965,0.06554246,0.018519692,-0.034701306,0.024933564,0.010041136,-0.061520703,0.027449073,-0.06700482,0.018308239,-0.11740823,0.04354609,-0.010429355,0.020493161,-0.04675481,-0.029792951,-0.052024744,-0.0067268554,-0.0006210216,0.048154406,0.055729713,0.06585596,-0.0048206933,-0.0013679257,-0.07062541,0.042541098,0.06461123,-0.061717644,-0.090817966,0.027938899,-0.017372759,-0.01447083,-0.051658098,0.010158766,-0.012177844,-0.01159665,0.010533674,0.018081903,-0.0038605323,0.023015762,0.060896274,0.0003549634,0.044596065,-0.04945908,-0.07705203,-0.034639124,-0.03154028,-0.028981727,-0.0510793,-0.07377494,-0.0033724932,-0.0115071945,0.16368556,0.06959249 +1.17.99.2,"Involved in the anaerobic catabolism of ethylbenzene by denitrifying bacteria. Ethylbenzene is the preferred substrate; the enzyme from some strains oxidizes propylbenzene, 1-ethyl-4-fluorobenzene, 3-methylpent-2-ene and ethylidenecyclohexane. Toluene is not oxidized. p-Benzoquinone or ferrocenium can act as electron acceptor. Contains molybdopterin, [4Fe-4S] clusters and heme b.",384,0.99999994,-0.015152756,-0.03873337,-0.056732956,-0.0054740007,0.11279835,0.02759347,-0.019007264,0.0793342,-0.03812075,-0.046058938,-0.02935245,-0.0290009,-0.02299039,0.09786458,-0.103816435,0.04792801,-0.015734639,-0.008902766,0.004903773,0.001923398,-0.008231268,-0.023005204,0.04885691,-0.0109164445,0.030413302,-0.012681789,0.032459613,-0.013559579,-0.028912542,-0.043826006,0.035184275,0.029400675,0.04230591,-0.022709874,0.007984435,0.101582594,-0.026453763,-0.047123536,0.05348481,0.009725134,0.03328234,-0.0021315017,-0.064336844,-0.07893073,0.0768443,-0.009315018,0.023943422,-0.02857125,0.01542464,-0.06211226,0.07489757,-0.04663573,-0.024889875,0.018538697,-0.024422018,-0.0912168,0.0297258,-0.030789912,-0.06368598,0.007614591,0.05541599,-0.040025797,0.0043265354,0.053299148,-0.02266282,-0.02746129,0.11728067,-0.02972872,0.028733455,-0.011833832,-0.08799381,-0.039690115,-0.0064155385,-0.003836115,-0.047038067,0.03680552,0.10876035,-0.047458656,-0.002151077,-0.10625103,-0.031975627,-0.013333679,0.0463998,0.04081145,0.08293945,0.038538817,-0.068171546,-0.04142668,0.047796644,0.0671123,-0.057949733,0.11989513,0.017354786,-0.019670004,-0.025167216,0.011224593,0.079411164,0.051905822,0.039665144,0.0074803177,0.009345651,0.14106092,-0.08240488,-0.09115753,-0.04614435,-0.037829656,0.06114604,0.016401978,0.029594317,0.005650469,0.0036327108,0.027799198,0.045380842,-0.0008645767,-0.0039376034,0.023246273,0.10882217,-0.013278209,-0.06912151,0.038456537,-0.056496955,-0.024227457,0.03161973,-0.009236707,-0.07003914,0.0034436139,-0.006726308,7.453016e-33,0.05091819,0.020981912,-0.018264413,-0.012303393,0.03460946,-0.0020269905,-0.07738237,0.042338595,-0.011272264,-0.070262715,-0.08406348,-0.06720085,0.06805443,-0.0021228953,-0.0045875534,-0.022529105,-0.009322721,0.041022267,0.021204198,-0.05898788,-0.017296026,0.019392999,-0.027444456,-0.016495004,0.059581522,-0.01694989,-0.003880312,0.032561526,-0.041026477,-0.04187236,-0.008607324,-0.061114658,-0.120500125,-0.017241705,-0.024649978,0.009780388,-0.0581065,0.04215926,-0.037740365,0.026695421,-0.014392217,0.07329044,-0.021823246,-0.037853308,0.043249805,0.018349713,-0.087553576,0.07600615,0.054048024,0.044231724,0.018002763,-0.02767497,0.10339679,-0.07237445,-0.059039757,0.035826936,0.02320655,-0.0100224465,0.0491958,0.019335482,0.06036958,0.044885855,-0.04194567,0.058671292,0.040923223,-0.032444984,-0.02598291,0.0701465,-0.03335643,0.007497564,-0.080144875,0.007991386,0.07309821,0.03293513,0.04153354,-0.052851047,-0.10509937,-0.10002287,0.009774387,-0.05242584,0.017687488,-0.06721586,-0.01754049,-0.096509345,-0.06019092,0.026098086,0.0088942805,0.020552283,0.043516923,0.01301733,0.094897434,-0.06927806,-0.025741868,-0.044399437,0.022457771,-6.5187105e-33,0.13506499,0.037684266,-0.027136706,-0.09423485,-0.027460085,0.046391577,0.006266785,-0.005025358,-0.0039234394,0.0067450246,0.0463231,-0.045939762,0.03420683,-0.06048793,-0.0166822,0.0203294,-0.047555275,0.046953708,0.012881018,-0.059048098,-0.04804833,0.031196078,-0.007668392,0.040840577,0.03152553,0.09139935,-0.07193147,0.037596542,0.065114245,-0.012308206,-0.020330576,0.0044074333,-0.019440858,-0.014063491,-0.008561742,0.093607284,-0.056573577,0.023362255,0.030479621,0.016546525,-0.009784549,0.05019725,-0.050605085,0.107425764,0.03424724,0.04542269,-0.12198407,-0.049285427,-0.01585729,-0.026286814,0.044955794,0.012110849,-0.048519805,-0.009498625,0.07784216,0.0606665,-0.01472854,-0.03529717,-0.06487666,-0.010450846,-0.011392089,-0.041267667,0.026827909,0.05974563,-0.011978069,0.029383903,-0.049667116,0.161187,0.036174726,0.0017374692,0.058317658,0.062764734,-0.0038272524,0.025976373,-0.08659516,-0.022261634,0.07165191,-0.026281541,-0.057089698,-0.053892016,0.044237368,0.013518899,-0.016853275,-0.015913138,-0.06902089,-0.07243723,-0.018833462,0.0499831,-0.0071383733,-0.042719226,0.021204958,-0.009666386,0.01226861,0.06385488,0.043802835,-4.7112497e-08,0.058041163,-0.08528727,0.0712392,0.03544565,-0.041169055,-0.026555255,0.0461514,0.0035868965,0.015901506,-0.07143213,-0.0070379185,0.038335882,0.037777364,-0.004653388,0.07170044,0.03351371,-0.07220602,0.017030593,-0.046084005,0.018411301,-0.0901496,-0.007862349,-0.16271037,0.069708556,0.053452093,-0.013929273,0.012127701,0.07838456,0.019779943,-0.028997954,-0.020785466,0.030618185,-0.01012949,0.02482256,-0.030565836,-0.0075771287,-0.006103596,-0.058257874,-0.037788104,0.00063357066,-0.0025507365,-0.07480799,-0.06519058,0.015123898,0.05759659,0.004435172,-0.014562058,0.026340077,0.028361239,-0.022192888,0.053591106,-0.040701434,0.026835004,-0.0134131685,-0.14294918,0.11068804,-0.057048023,0.019889282,0.007945294,-0.08485108,0.026206883,-0.036747877,0.19368514,-0.051656242 +1.17.99.3,"Requires ATP. The reaction in mammals possibly involves dehydrogenation to give a 24(25)-double bond followed by hydration [1]. However, in amphibians such as the Oriental fire-bellied toad (Bombina orientalis), it is probable that the product is formed via direct hydroxylation of the saturated side chain of (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate and not via hydration of a 24(25) double bond [5]. In microsomes, the free acid is preferred to the coenzyme A ester, whereas in mitochondria, the coenzyme A ester is preferred to the free-acid form of the substrate [1].",384,1.0,-0.048616942,-0.044967003,0.043331668,-0.00869378,-0.01306542,0.04446489,-0.028081281,-0.011957037,0.023413127,0.046433765,0.06282563,-0.03860167,-0.0050657415,0.006666437,0.005088457,-0.053858764,-0.042665575,0.024298644,-0.029561607,-0.037547838,0.07901096,-0.038195867,0.028196873,-0.035068743,0.0058918875,-0.08699272,0.028110933,-0.025360096,-0.0114655215,-0.07471207,-0.035546713,0.039303977,-0.0113750445,-0.08344153,-0.026885282,0.048068456,-0.032653067,-0.04814684,0.04669403,0.016924715,0.054272704,-0.06292942,-0.03188162,0.03346514,-0.079891026,-0.057268154,-0.007529266,-0.01360098,0.045963746,0.028353991,-0.033859573,0.014582433,-0.09933743,0.033072095,0.0041730003,0.07949147,-0.093710825,0.06536605,-0.060516052,-0.015224074,0.01705985,-0.018053198,-0.014290318,0.016328221,-0.026103493,-0.03341648,0.024819743,0.013778315,0.035562776,-0.05578812,0.006243329,-0.03289739,0.022615178,-0.05551184,-0.07494471,0.012992385,-0.018243728,-0.058794048,-0.052430157,0.062895656,-0.05850648,-0.017441185,0.023251567,0.0480912,0.08288945,-0.03172299,0.01255068,-0.0094108,-0.00053568673,0.023540394,0.015416855,0.0353974,-0.071580306,-0.05247779,-0.08126213,0.0334479,0.09425792,0.008931721,-0.021741753,-0.0036226362,0.054064218,0.07813153,0.033075765,-0.04253349,0.013912215,-0.03343881,-0.01041276,0.03418257,0.0420998,0.014899461,0.050408673,-0.026225094,0.07660978,0.0139106065,-0.031745948,0.05432757,-0.039299525,-0.077208295,0.040370557,-0.043202892,-0.034864306,0.014007998,0.032392032,0.020278126,-0.04254132,0.022385566,-0.13136551,2.291518e-33,0.037934724,-0.027632345,0.030361563,0.042582374,-0.061786857,0.05826047,-0.10992447,-0.0049394085,-0.057676755,-0.06890493,-0.04625633,-0.026520036,0.06570584,0.009908289,-0.02529846,0.0078058965,0.0045300103,0.020044953,0.14252533,0.009800546,-0.027988596,0.07328449,0.012629201,-0.08404062,-0.005929356,-0.10331125,-0.017390369,-0.037822288,0.038297918,0.0090517,-0.0680419,-0.07681145,0.007802405,0.04654789,-0.00036552825,0.012881101,-0.12702233,-0.0209063,0.011675852,0.024600089,0.02571249,0.018116621,0.01119965,-0.03959508,0.059012696,-0.022457348,-0.009792215,0.037606925,0.034194153,0.02226526,0.032257617,-0.01383102,0.10637943,0.03673527,-0.06927945,0.04909314,-0.03250679,-0.034216978,-0.085231744,0.106209904,-0.022466889,0.027937125,-0.015677895,0.045612566,0.005370279,0.0047629396,-0.114845484,0.009310396,-0.018895352,-0.0019301871,-0.017505601,0.035571307,0.1131331,-0.010168373,0.035957817,0.0045627197,0.002765801,0.029430497,-0.0024826739,0.033807058,0.05476149,0.031219987,-0.056139365,0.08505666,-0.04439946,0.06284631,0.03373475,0.009075855,0.0969615,0.08223764,0.046205472,-0.13216798,-0.005129564,-0.029250598,0.076128155,-3.3798416e-33,0.124119475,-0.07690848,0.0051634423,-0.071178995,0.042638537,0.02966597,0.075915195,-0.09451791,0.006708161,-0.04882681,0.043881696,0.06562789,-0.0503149,-0.0931391,0.008811648,-0.011833448,0.0164428,0.05638903,0.030238297,-0.064151175,0.01652148,0.08298929,0.025152566,0.08435785,0.04132624,-0.010433781,-0.0006078217,0.020361105,0.043178577,0.08884911,-0.0075676376,0.025281072,-0.009193249,0.02880366,0.016101792,0.026419474,-0.08750839,-0.015288415,0.047474828,-0.0074106636,-0.030933099,0.03164334,-0.0044337623,0.012262091,0.10707288,0.019210188,-0.039022245,-0.106399104,-0.01123169,-0.007857089,0.0058480855,-0.07734826,-0.123128764,-0.086197935,0.0851681,-0.0011555421,-0.015734091,0.022116715,0.0772375,-0.050888043,-0.020522367,-0.030771026,0.022961712,-0.067104094,-0.09522188,0.0900407,-0.022153404,0.024944527,0.0067148334,0.03158716,0.030698393,0.082534656,-0.00069179904,0.00989203,0.07317733,0.008989627,0.0030726637,-0.019006955,-0.029352454,-0.032971736,-0.07833573,0.055778872,-0.108730555,-0.05727936,-0.02425294,-0.10226722,0.0031146568,0.02802375,-0.05379376,0.023623165,0.011520869,-0.05557799,-0.05394082,0.10018024,0.06277423,-5.040575e-08,0.02713918,-0.0357436,0.009539215,0.03360414,-0.05086869,0.036470175,0.094038084,-0.036480907,0.072616756,-0.046213727,0.056284092,0.04426369,0.059321586,0.10880676,0.040673204,-0.013738183,0.032222953,-0.03332907,-0.098885864,-0.06137208,-0.13124356,0.0070298957,-0.08440296,0.063249566,-0.039545324,-0.05538258,0.011751133,0.042394955,-0.027076025,-0.089535415,0.019536184,-0.009296882,-0.053245142,0.0094317645,0.02542133,0.015034752,0.022581197,0.03239374,0.0347739,0.046507325,-0.028761243,-0.026191229,-0.023296094,0.054910682,0.10733723,-0.032981392,-0.022115061,0.06267046,-0.0009531057,0.03330043,0.03141446,0.037582535,0.043008327,-0.044678282,-0.05453661,0.010204602,-0.019315174,-0.021165645,-0.029236946,-0.006097281,0.020377457,0.008056662,0.16546854,-0.08599677 +1.18.1.1,"Requires FAD. The enzyme from Clostridium acetobutylicum reduces rubredoxin, ferricyanide and dichlorophenolindophenol, but not ferredoxin or flavodoxin. The reaction does not occur when NADPH is substituted for NADH. Contains iron at the redox centre.",384,0.99999994,-0.06409605,-0.026244475,-0.07265914,0.036408536,0.115303926,0.029496998,-0.051788058,0.035312723,0.008601463,-0.06021272,-0.0554376,-0.0014387544,-0.02108144,0.0740872,-0.020874936,0.011641351,-0.010496473,0.03899113,0.03760095,0.041380823,0.013025156,-0.013637662,0.05685265,-0.026357247,-0.005319482,0.0150912795,0.03639974,0.0059031174,-0.041671384,-0.034061953,0.001837486,0.022639537,-0.00033376715,-0.034178052,-0.0033690885,0.0662324,-0.03668823,0.027827982,0.043691102,0.026431587,-0.057015635,0.005373074,-0.005501856,-0.035432752,-0.007921967,-0.061688054,-0.009722671,0.04077226,0.039558165,0.020311683,-0.05344083,-0.006701715,-0.049637735,0.01635905,0.076543346,-0.02719431,0.026848925,-0.05922628,0.00888651,-0.004926358,-0.003988006,-0.072266616,-0.029307477,0.017508386,0.045842305,-0.044145398,-0.0029465372,-0.045218155,-0.017684039,-0.039459556,0.011737801,-0.008974516,0.0074673616,0.014872484,0.06466306,0.08286956,-0.05617493,-0.050009996,0.03323234,-0.023393568,-0.005842479,-0.00060265645,-0.009931306,0.113360524,0.08871962,0.04754505,0.0034853206,-0.050063133,-0.07201991,0.08995471,0.08674311,0.06485145,-0.018337421,-0.05146343,-0.09314669,0.031164225,0.02596929,0.020434577,-0.062106278,0.0014347574,-0.043699667,0.039153196,-0.045245577,-0.09506613,-0.07440896,-0.05093966,0.024059638,0.08209606,-0.052798253,-0.018167572,0.01870101,-0.005355493,0.020352714,-0.054764815,-0.01039649,0.051433176,0.08505813,-0.062723614,-0.047207985,0.0018336058,-0.011212044,0.037564196,0.023070114,0.0765838,0.031550903,0.013845413,-0.053268265,8.45662e-33,0.11404892,0.074142925,-0.089254126,-0.025499748,0.031882383,0.066356845,-0.10142475,-0.028945975,0.045071114,-0.03944567,-0.031893294,-0.038238008,0.05310547,-0.11793083,-0.00012888647,-0.013722031,-0.06703677,-0.102387175,0.036526136,-0.06912412,0.09610319,0.028346984,-0.008652646,0.10606162,0.008560509,0.034219682,-0.07631544,0.06528792,-0.012087658,0.010045881,0.034786116,-0.06470534,-0.07926711,-0.032150023,0.0026486185,0.03168049,-0.06976846,-0.08368915,-0.079959735,0.015803339,-0.025816543,0.05403888,-0.07394624,-0.0040061646,0.063661255,-0.12770243,-0.029415455,0.14660886,-0.0011424533,0.097524635,0.056733776,-0.027736612,0.12981471,-0.063729614,-0.070471436,0.03760417,-0.008781678,-0.047051616,0.050788492,0.05602024,0.08290813,0.026649179,0.004139096,0.061893813,-0.016315697,-0.010791355,0.0074694823,-0.049186137,0.021456338,0.03706542,-0.002185692,-0.0188344,0.0383472,0.056160368,0.048337843,-0.0624092,-0.037792478,-0.06508079,0.0720359,-0.031941056,-0.008362463,-0.052764665,0.018743405,-0.015971964,0.02989813,0.032538407,-0.063516915,-0.009191388,0.026267115,-0.021344434,0.057000194,-0.089606516,-0.026337676,-0.027528794,-0.014355268,-7.2261715e-33,0.056488853,-0.07811584,0.09681581,-0.037362657,-0.04536611,0.044480957,-0.00889389,-0.08722942,0.054474026,-0.034405448,0.062412433,-0.049174674,0.020992748,-0.008075851,0.020706993,0.02628069,-0.04977311,-0.016070504,-0.003862642,0.026232904,-0.071157366,0.080832854,0.030499035,0.05966099,0.0850359,0.010891175,-0.04748531,0.009310073,0.10038994,0.05851258,0.027215833,0.051179502,-0.08510233,-0.04871865,-0.04639954,0.04547837,-0.059381824,0.04456474,-0.02792548,0.04452338,-0.0048032613,-0.041850284,-0.05999,0.049666766,0.035791673,0.012065359,-0.09577358,0.004287845,0.07350104,-0.030644234,0.0032306279,0.02727403,-0.019151337,-0.017452497,0.057449996,0.016365955,0.029067587,-0.040754803,0.027804496,-0.02288688,-0.011609343,-0.05951786,-0.0061041974,0.019926801,0.09707056,0.05846063,-0.017324036,0.13529767,0.07327425,-0.049416848,0.04931588,0.0076512117,0.06453818,0.021245072,0.020041658,0.013770589,-0.015516742,0.10856727,-0.0039712475,0.04370834,0.01849388,0.054870646,-0.08190367,-0.009726205,-0.062731266,-0.0411744,-0.020426024,0.015475375,-0.032960024,0.011564808,-0.04968368,0.044827223,0.06897282,-0.026898315,0.020055465,-3.9618847e-08,0.018159129,0.008874824,0.09746224,-0.015408832,0.057310566,-0.01980783,0.015758134,-0.03118979,-0.033601098,-0.037499722,-0.032840155,0.16555135,0.055372596,0.018198095,0.027224556,-0.012351583,-0.034984373,0.03404601,-0.029288586,-0.007788109,-0.07318545,-0.0029254619,-0.12751685,0.102644056,0.014912665,-0.056041915,0.026404021,-0.053731397,0.005025463,-0.011136845,0.0139113655,-0.02280847,0.021537816,-0.06290143,-0.12152997,0.03742456,0.00077750586,-0.01928008,-0.004028851,0.045449503,-0.031795673,-0.022897651,-0.066992015,-0.029191542,-0.05766544,-0.0596591,-0.008817299,-0.020341964,-0.0525845,-0.027054045,0.048187565,-0.020911982,-0.0015734109,-0.025058534,-0.02184331,0.027029904,0.064762756,-0.05452358,0.018606905,-0.08693991,-0.03561101,-0.009886836,0.16374558,-0.019003456 +1.18.1.2,"A flavoprotein (FAD). In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe-2S] ferredoxins, but in other bacteria it can also reduce bacterial [4Fe-4S] ferredoxins and flavodoxin.",384,0.9999999,-0.09994181,-0.03371416,-0.07352582,0.039526552,0.12582697,0.04405627,-0.014338683,0.05677528,0.017167142,-0.062200017,-0.010701621,-0.0069857826,-0.09062231,0.010714387,-0.09467866,0.024958048,-0.10138787,0.041686535,-0.043934595,0.004392145,-0.02091294,0.0026481075,0.019198658,-0.047367312,-0.010808596,0.0086999,-0.025044814,-0.043268915,-0.03331501,-0.03921375,0.045998916,0.090870894,0.08910114,-0.018523498,-0.041815665,0.055759538,0.08094484,-0.05096134,0.042893108,0.0005167754,-0.02017367,0.007644987,0.07344225,-0.018848179,0.029366259,0.020981032,0.030092562,0.0057792226,-0.0065333317,-0.008112941,-0.024833778,-0.019597886,-0.10186644,0.0695643,0.030315273,0.006781491,-0.002710768,-0.05311351,0.0057745557,0.017145207,0.03813898,-0.059197772,0.029316243,0.043489467,0.04628647,-0.035228826,-0.07818321,-0.029775092,0.009717819,-0.037224036,0.031105123,0.00063305517,-0.030075168,0.04533075,0.031069033,0.06504577,-0.03574538,-0.036420837,0.048744567,0.014254638,0.04921433,-0.03539439,0.06857674,0.05531328,0.040743392,-0.057058346,-0.028431812,-0.045460347,-0.08674255,0.08469488,0.050606664,0.048811503,0.021717556,-0.009408231,-0.10090258,0.07476956,0.048477743,-0.09440058,-0.036634233,0.0017478156,-0.073563956,0.01230147,0.02118807,-0.029965099,-0.010020758,-0.07044933,-0.034572393,0.05389439,-0.010348902,-0.026007984,0.011432015,-0.02061364,0.01319723,-0.058635194,-0.014671266,0.009613132,0.022771766,-0.06936881,-0.012551181,0.012691138,-0.026100978,0.048049934,0.015588488,0.068146035,0.027151575,0.012088973,-0.15133657,4.685731e-33,0.08346685,-0.023094421,-0.032056786,-0.018645838,0.05873626,-0.028549861,-0.064760655,-0.041307047,0.05038104,-0.054269545,-0.0684541,-0.02056899,0.032156825,-0.0847788,0.041805215,-0.021779412,-0.07516074,-0.07118896,0.06320313,-0.08654419,0.06971973,0.05789587,-0.016845444,0.047578163,0.068233185,-0.010394181,-0.046944056,0.023026489,0.03348311,0.020800943,0.0027264901,-0.053708985,-0.08177638,0.019262899,0.009192674,0.03215518,-0.07755976,-0.08323163,-0.09890218,0.04584049,-0.04470505,0.0014538274,-0.039713986,-0.014691902,0.09424922,-0.056209885,-0.06520773,0.09037577,-0.005133253,0.13348556,0.039595854,-0.05456854,0.07095956,0.07057684,-0.0398027,0.018048346,-0.020962942,0.00927893,-0.0035062695,0.039964635,0.025840355,0.059550114,0.003957668,0.05391495,-0.025222229,-0.0024668726,0.012358448,-0.06265446,-0.010548374,0.11966108,0.010113995,-0.020195147,0.0686913,-0.0005108945,0.08464965,-0.05002289,-0.0066066054,-0.062977426,0.0013017177,0.021304866,0.00027863588,-0.021451911,0.008319873,-0.040437732,-0.043084722,0.0027773,-0.047578163,-0.02870268,0.037508015,-0.021237396,0.046585392,-0.053350143,-0.0020279298,-0.009575163,-0.017033266,-3.956543e-33,0.029852001,-0.11662516,0.07406692,0.052290224,-0.03411688,0.037843097,0.007350537,-0.049826562,0.01739051,-0.009752084,0.04843879,-0.038105052,0.005840375,-0.0041782227,0.054075647,0.014549922,-0.040753063,-0.0029776876,0.022016084,0.05557917,-0.08190677,0.014985168,0.057051513,0.06803905,0.047520958,-0.0055953786,-0.02290666,-0.01495154,0.0546948,0.010880414,-0.0371941,0.008316017,-0.08377618,-0.023981147,-0.039182454,0.00045054697,-0.018054437,0.015898207,0.011963541,0.028516404,0.02112617,0.007342845,-0.009599737,0.084536575,0.03491998,0.014303691,-0.064674184,0.0543788,0.0543207,-0.031020438,-0.033633936,0.0063659744,-0.03450345,0.04566325,0.050301377,0.0028395045,0.10673527,0.05686947,-0.033945743,0.06137569,0.012800092,-0.1461473,0.042681403,0.04786832,0.11343951,0.091183536,0.003377472,0.15589249,0.0010013465,0.05731037,0.12681593,0.007768446,0.07611388,0.035679482,-0.0067254044,-0.023470767,0.0072568804,0.047030192,-0.014187446,0.040149216,0.014318616,0.029050352,0.0015143383,0.03538965,-0.079070866,-0.13876949,0.0011574619,0.062101,-0.0017862306,0.03526544,-0.04408445,0.05437398,0.048265588,-0.05686268,0.05296943,-3.4196383e-08,-0.014362826,-0.058223024,0.0032032162,-0.021209436,0.08361344,0.0024607705,-0.08425331,-0.02061991,0.00779959,-0.034548998,-0.062181637,0.13590263,0.009516424,-0.040416744,0.07608535,-0.058940027,-0.0025089881,-0.010295909,-0.021147594,0.0274644,-0.07729145,0.031401865,-0.14401148,0.046617553,-0.027313631,-0.04261452,0.01726458,-0.0049933065,0.043307148,-0.0035053366,0.017461589,0.024819475,-0.0060514114,-0.042430375,-0.15102112,-0.006663035,0.02737763,-0.107807055,-0.057862386,0.031632487,-0.069098376,0.009717647,-0.044496167,-0.041331917,-0.034748737,-0.01501327,0.0693893,-0.008717335,-0.030967211,-0.004266674,0.021492496,-0.020710014,0.018479079,-0.007275086,-0.064394355,0.02645051,0.020735277,-0.019317567,-0.017099088,-0.0417628,-0.05781666,0.015294002,0.14195457,0.029257746 +1.18.1.3,"Contains FAD. Reaction (1) is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems. The alternative reaction (2) is written for a 2[4Fe-4S] ferredoxin, which transfers two electrons, and occurs in metabolism of anaerobic bacteria. ",384,0.99999994,-0.06595103,0.01666272,-0.057180643,0.04836824,0.08534991,0.02406642,-0.047237646,0.039827567,-0.012873971,-0.03990392,-0.041781913,-0.09140385,-0.024561262,-0.019766118,-0.08777935,-0.015928533,-0.06653616,0.0039968924,0.021142995,0.012506135,0.0048141745,0.028847259,0.019140525,-0.058562074,0.0041723545,0.07246264,0.009030806,0.0064999997,-0.054271836,-0.0452506,0.037983887,0.07825658,0.07334037,-0.059644315,-0.031855885,0.10038264,0.048464987,-0.016096124,0.07419368,-0.013486656,-0.05054272,0.0050435322,0.051683318,-0.025650783,0.0074517448,-0.013325278,0.031535584,-0.031127313,0.025292464,0.00537722,-0.048482552,-0.021264667,-0.08237774,0.08261499,0.09430833,-0.04605017,0.014188921,-0.052571695,-0.052103136,-0.018173926,0.03839875,-0.04547329,-0.03699381,0.0454387,0.035116345,-0.028616883,0.0010761338,-0.06257335,-0.032954644,-0.041873194,-0.021819988,-0.004197673,0.021542404,-0.05267683,0.0071567823,0.046630304,0.018246263,-0.05466264,0.04891319,-0.04733125,-0.019877125,-0.043304827,0.07143871,0.040246364,-0.00490866,-0.0027566089,-0.035055477,-0.046185214,-0.026325824,0.034422748,0.03494227,0.052695993,0.056416065,-0.045946747,-0.049004167,0.05285564,0.0028025554,0.04140028,0.07098195,0.01632494,-0.058422524,0.08146287,-0.04710259,-0.06455655,0.013606365,-0.041150082,-0.007195094,0.1288295,0.020101294,-0.032312926,0.035848875,-0.010913335,0.063408285,0.03805525,0.01780181,0.025185922,0.0455925,-0.05871792,-0.028206801,0.017302515,0.025148112,-0.0014141569,-0.003218956,0.021692043,-0.030611772,-0.06152911,-0.12165754,1.5849556e-33,0.0896332,0.047674313,-0.031398095,0.00969511,0.029995734,0.009756633,-0.08516387,-0.061363056,0.05111574,0.0013442979,-0.06280858,-0.04686465,0.09554959,-0.009063166,-0.0495517,-0.08632727,-0.021915928,-0.06846081,0.09307273,-0.06520824,0.06205171,0.10088451,0.0012832729,0.033155598,0.043254446,0.0636396,0.002548321,0.0005647465,-0.014637991,-0.0035088432,0.06473055,-0.046811,-0.09954682,0.0061754733,-0.011516207,-0.030396199,-0.03281267,-0.015747309,-0.0726738,0.014075736,-0.046941884,0.052494846,-0.04808303,-0.072729014,0.12758079,-0.07444044,-0.055043742,0.11328169,0.075886175,0.1305132,0.015973033,-0.037041593,0.08554668,-0.01147483,-0.015495053,0.050951168,-0.021682415,0.045582473,0.07549076,0.09121645,0.03309421,0.06903711,0.021237,0.027404634,-0.0013654715,0.042558406,-0.006869104,-0.036068633,-0.034309473,0.09934065,-0.02802722,0.04410847,0.087185554,0.0040367623,0.063411154,-0.05950691,-0.07048717,-0.10988611,0.047505267,-0.014481195,0.011328381,0.008686739,-0.049851213,-0.029578362,-0.02237648,0.01304111,-0.076532975,-0.023337143,0.0055227457,0.07714565,0.032540657,-0.07167042,-0.07260817,-0.054979667,0.039231293,-2.0384756e-33,0.05533481,-0.06017624,0.014901923,-0.052302282,-0.09485836,0.045047678,0.029837413,-0.043778084,0.050937463,0.01135424,0.085771106,-0.0029594477,-0.016697641,-0.030599736,0.006205321,-0.023350578,-0.03232429,-0.0014575627,0.049827553,0.028452268,0.0020779571,0.043871332,-0.015269113,0.023541508,0.117945395,0.012265156,-0.024196276,0.02616371,0.07568624,0.0498751,0.013176645,-0.05465619,-0.023013307,0.0035202086,0.0042334595,0.009999176,-0.026478536,0.0070677805,0.018620402,0.0076326425,0.009003667,-0.016374681,0.03731314,0.13555317,0.063607275,0.020804534,-0.14269106,0.016309174,0.034348704,-0.0497854,-0.035937514,-0.050752703,-0.08103898,-0.049052298,0.042888965,0.023211373,0.07393499,-0.004093382,-0.00613121,-0.0027848259,0.007510174,-0.08635907,0.08286434,0.012913661,0.039055284,0.055103123,-0.072166845,0.09647194,0.0372111,0.04484756,0.09332856,-0.016807692,0.038287867,-0.008965213,0.0027339542,-0.03461698,0.018384643,0.0077281306,-0.008903176,0.053123362,-0.0012801357,0.064173974,-0.004644832,0.01653826,-0.093055435,-0.12199726,0.046717368,0.039772745,-0.029997116,-0.06211143,-0.011934013,0.066692606,0.092722796,-0.023169935,0.044824254,-3.6806565e-08,-0.043903623,-0.08137605,0.08527112,-0.00025864615,0.060897347,0.084743746,-0.041535076,-0.09571484,-0.02542838,-0.04961204,0.019459995,0.12911735,0.003305113,-0.066450074,0.047858626,-0.025237838,-0.0318374,-0.039740793,-0.052047856,-0.012840009,-0.060443003,-0.010059638,-0.1092018,0.03328295,-0.010509194,-0.042391192,-0.007723842,-0.084496506,-0.011342534,-0.04555494,-0.02625593,0.028618738,-0.018941114,-0.052425336,-0.08205969,-0.043816086,0.0034461243,-0.060452443,-0.013939841,-0.007911564,-0.0054614246,-0.0064631114,-0.07200361,-0.013702765,0.0011069376,0.02532847,0.010362433,-0.045579225,-0.056065243,-0.019240474,0.050588183,-0.062466227,0.049365167,0.03323668,-0.07802765,0.08830116,-0.03036901,-0.02029,0.04902845,0.0064278864,-0.0030987354,0.050692707,0.101517536,-0.0371523 +1.18.1.4,"The enzyme from Pyrococcus furiosus requires FAD. It reduces a number of electron carriers, including benzyl viologen, menadione and 2,6-dichloroindophenol, but rubredoxin is the most efficient. Ferredoxin is not utilized.",384,1.0,-0.05754598,-0.022813587,-0.06685606,-0.009751916,0.084633194,0.020197839,-0.061147776,0.074773,-0.03228817,-0.015703112,-0.009144047,-0.0051390636,-0.08624785,0.09740059,-0.029439315,-0.0008316805,-0.046436876,0.028046496,0.039107494,0.0004417617,0.04132315,-0.03820627,0.054766234,-0.030324671,-0.021927038,-0.01505606,0.017533954,0.031428013,-0.007910957,-0.026408387,0.011529043,0.027841413,-0.016299263,-0.066533856,-0.029330367,0.04201673,-0.046638366,0.0021422736,0.067459196,0.031575322,-0.040588494,-0.010834054,0.0072279368,-0.026538804,-0.01738175,-0.034655444,0.08984401,0.028774856,0.036808148,-0.041192085,-0.0357468,0.035164285,-0.07910787,0.037101563,-0.042069368,-0.046590503,-0.018801415,-0.09300388,-0.035554897,-0.047481634,0.005797291,-0.013522881,-0.017933393,0.004985583,0.0035255668,-0.016575025,-0.01928102,-0.004016945,0.017264051,0.0075277016,-0.0017971115,-0.024007803,-0.013903931,0.0043014484,0.015895396,0.07906779,-0.03124743,-0.07636305,0.045231365,0.008304477,0.013332363,-0.032747746,0.0037161259,0.14663684,0.07665809,0.015460922,0.0479764,-0.021763641,-0.069443606,0.06455744,0.06389022,0.067374215,0.003914006,-0.044922393,-0.07768618,0.04313339,0.026404655,0.04786792,-0.053596225,-0.015786607,-0.045726616,-0.021790372,-0.06235014,-0.045587633,-0.068410516,-0.027350483,-0.00026048758,0.06448695,0.042355448,-0.030228589,-0.010793498,0.058917884,-0.09726323,-0.04475026,-0.035197362,0.051241424,0.07534197,-0.10890846,-0.013938813,0.07103058,0.01690545,0.023222726,0.044571523,0.06479248,-0.012868335,-0.009194876,-0.05505917,5.3594406e-33,0.002118222,0.054710403,-0.051591463,-0.047928687,0.003846045,0.04095317,-0.12755267,-0.052089524,-0.0075010466,-0.04643895,-0.09811009,-0.009276366,0.05655787,-0.049499515,0.007100405,-0.07599843,-0.012410494,-0.02709663,0.07046841,-0.077424444,0.12767778,0.060741983,0.017683761,0.04844481,0.069056965,0.047313806,0.023791037,0.07685809,-0.04276544,-0.0052486737,0.057982277,-0.09012017,-0.06367421,0.0072669936,0.013280195,0.018589092,-0.09622839,-0.09169792,-0.02253114,-0.022753906,-0.034560144,0.049721286,-0.012892417,-0.0031538745,0.09025662,-0.077553466,-0.091046065,0.115634024,-0.038133565,0.09943773,0.06869876,-0.0016840663,0.07511253,-0.017254118,-0.07212492,-0.037590463,0.024462448,-0.060273778,0.01828109,0.06107325,0.050979234,0.024232622,-0.008507517,0.03496163,0.010363934,0.019458069,0.033070754,-0.0005673262,-0.045905128,0.0885492,-0.0776587,0.0312601,0.06590487,-0.01850757,0.04778228,-0.024606658,-0.009950751,-0.006787186,0.0314705,-0.046327442,-0.013327701,-0.021286173,0.0031472677,-0.0019158624,-0.031898804,-0.016125357,-0.076902844,0.020183766,0.05357805,0.044397462,0.053837825,-0.07435022,-0.0164876,0.0137231685,-0.018859398,-3.8969687e-33,0.06120377,-0.07795129,0.10858059,-0.011238007,-0.026778424,0.07681161,0.080254115,-0.05312861,0.04562722,-0.023430439,0.038148154,-0.03712758,0.019283125,-0.017241042,0.0374856,0.055938277,-0.05560574,-0.064397514,0.08613512,0.002306067,-0.07034058,0.08762735,-0.024225162,0.029722812,0.039322153,0.009113011,-0.079570025,0.0215423,0.08043548,-0.00090890547,0.0042847693,0.009662522,-0.051651902,-0.059057876,-0.02785325,0.060925502,-0.0062270435,0.099707656,0.018900715,0.04409359,0.017340254,-0.005526778,-0.0087078,0.087008186,-0.0051708743,0.05494384,-0.1406843,0.0012789464,0.04756326,0.008102239,0.025207603,0.023950243,-0.030483754,-0.039973274,0.06210356,0.013334897,0.06890203,-0.046748158,-0.012015501,0.036599305,0.020681197,-0.105369054,0.0049222684,0.046920966,0.0071784956,0.041552838,-0.04025283,0.12584047,0.0055418336,0.055481244,0.11590823,0.08132703,0.04842087,-0.0030572189,-0.04365097,0.043495085,0.080654606,0.034608576,0.024592826,0.049325198,0.067243665,0.03502614,-0.07446046,-0.02941261,-0.06768998,-0.057150055,0.04853834,0.011749661,-0.0074333693,-0.025567776,0.005004042,0.02081439,0.08068652,-0.039094698,0.07337847,-3.5520472e-08,-0.029609151,-0.03461997,0.061650224,-0.021921314,0.0427858,-0.0006375207,-0.026476614,-0.0020459692,0.036494866,-0.07947882,0.01360078,0.10304382,0.02120711,-0.019734478,0.050280705,-0.024554746,-0.050355967,0.0127611365,-0.010567706,-0.0051350244,-0.11539646,0.044635624,-0.17081492,0.018501343,0.005162895,-0.040825367,0.08182224,-0.061034545,-0.009008317,0.015541917,-0.010703799,-0.024400976,-0.01178347,-0.03751947,-0.098244846,0.034152742,-0.052488856,-0.03391379,-0.03325191,0.020981923,0.012807117,-0.0080936635,-0.0424419,-0.017159134,-0.001863295,-0.03227302,-0.025791673,-0.058711234,-0.004761702,0.026911052,0.08996964,-0.011777976,0.03313192,-0.061441064,-0.10135776,0.06965913,0.018341213,-0.055193644,-0.0401497,-0.088596605,0.022776864,-0.029951656,0.14387222,0.038219575 +1.18.6.1,"Requires Mg2+. The enzyme is a complex of two components (namely dinitrogen reductase and dinitrogenase). Dinitrogen reductase is a [4Fe-4S] protein, which, in the presence of two molecules of ATP, transfers an electron from ferredoxin to the dinitrogenase component. Dinitrogenase is a molybdenum-iron protein that reduces dinitrogen to two molecules of ammonia in three successive two-electron reductions via diazene and hydrazine. The reduction is initiated by formation of hydrogen in stoichiometric amounts [2]. Acetylene is reduced to ethylene (but only very slowly to ethane), azide to nitrogen and ammonia, and cyanide to methane and ammonia. In the absence of a suitable substrate, hydrogen is slowly formed. Ferredoxin may be replaced by flavodoxin [see EC 1.19.6.1 nitrogenase (flavodoxin)]. The enzyme does not reduce CO (cf. EC 1.18.6.2, vanadium-dependent nitrogenase).",384,1.0,-0.05656492,-0.0056453072,-0.10983653,0.014224052,0.104163684,0.0103466,-0.04476512,-0.024260014,-0.01474927,-0.08259929,-0.06943435,-0.028245406,-0.028226798,-0.016520899,-0.047677882,-0.061593488,-0.00510542,0.017742436,0.011593847,-0.005556937,0.018065501,-0.04387839,0.021908473,-0.056592986,0.027913712,0.008980346,0.016318701,-0.022804175,-0.061081965,-0.076298855,0.024869157,0.027433481,0.031114243,-0.039148167,-0.031317916,0.063263685,-0.05503967,0.022526607,-0.0039530285,0.013951855,-0.004413055,-0.008110453,0.024853732,-0.08589544,0.01456573,-0.04143269,0.00069256034,0.00483711,0.008583896,0.0030704702,-0.04758189,-0.0064554806,-0.012135481,0.023688933,0.035541337,-0.01425354,-0.069075994,0.0022565566,-0.06363482,0.024924451,0.07252661,-0.029673927,-0.026148664,-0.050708752,0.09904738,-0.036947347,-0.003351637,-0.10666386,0.058025192,-0.026388882,-0.0069271163,-0.028335767,-0.029732756,0.031198869,-0.00894325,0.05410055,0.0097352555,-0.002371468,0.09213443,-0.040258154,-0.007304151,0.07396924,0.056680497,0.033059455,0.06868482,-0.013164784,-0.029349603,-0.0074714385,-0.056235354,0.053675093,-0.019256175,0.08921319,0.018254347,-0.012362224,0.00175225,0.036601752,0.020539165,0.028159035,0.013929808,0.01350436,0.018535595,0.10344832,-0.1320873,-0.110516235,-0.10595125,0.006192481,0.054144442,0.09848316,0.020251693,0.02982111,0.001304592,0.027157318,0.046322897,-0.000532417,0.019742867,0.09467241,0.014791851,-0.040117975,-0.041308243,0.09114819,-0.011724467,0.012286858,0.06519065,0.08524787,0.009113564,0.038914148,-0.10941511,4.543319e-33,0.03259832,0.05101153,-0.014609354,-0.004184743,0.020535745,0.009687964,-0.0527516,-0.0009254829,0.009764513,-0.030009791,-0.040634427,-0.013170473,0.03930048,-0.07447443,-0.030200439,-0.092551716,-0.0069840727,0.00073435646,0.0557549,-0.00030226598,0.047143064,0.07782155,-0.054095425,0.09602727,0.0243328,0.054816414,-0.0019406709,0.0037896652,-0.016236654,-0.01570924,0.005783292,-0.094508484,-0.07826507,0.044608217,0.04545785,-0.09481632,-0.06578871,-0.010959021,-0.04785106,0.032639187,-0.07318811,0.014404408,-0.055231046,-0.02714671,0.014823495,-0.047663238,-0.03853505,0.08885981,0.03839802,0.049272176,0.058677316,0.0030412911,0.077909164,0.004972186,-0.101622656,0.07134956,-0.028212389,-0.008447688,0.063833766,0.019861689,-0.01640396,0.041741997,0.042832986,0.041766923,-0.024204787,0.07434785,-0.04604696,-0.06362613,0.04757986,0.080101706,-0.022755323,0.022484703,0.07909367,0.04255329,0.087129064,-0.025871497,-0.0043453826,-0.061084744,0.028008562,-0.006978869,-0.0024992994,0.042261418,0.013364572,-0.04195962,-0.06368509,-0.088092834,-0.036572486,-0.0109628355,0.05459607,0.017700894,0.033436976,-0.10447771,-0.053237725,-0.056519724,0.039305367,-4.1656886e-33,0.0900932,-0.050461415,0.0040966864,-0.07420601,-0.0706776,0.043057226,0.05328171,-0.087323174,0.037812687,-0.026806729,0.13422263,-0.04798865,0.04732247,-0.02917834,-0.03680304,0.00926504,0.002190628,-0.001923955,0.052491736,0.0073980284,-0.061489645,0.07780393,-0.00016587012,0.009047716,0.01996418,0.029783862,-0.041699775,0.03214114,0.10897349,0.045077458,0.008436943,0.03729931,-0.07896271,-0.058755573,-0.006988556,0.061512463,-0.05709349,-0.0017755287,-0.077124365,0.021796154,0.025112195,-0.029178403,0.024544947,0.10029108,0.07286023,0.0067379503,-0.06966349,-0.010667388,-0.0017273193,0.0027437955,0.076297596,-0.02047074,-0.049150266,0.00011574918,0.018803071,0.032986686,0.08057162,0.029847624,0.014376859,0.072810076,0.024295114,-0.09435134,0.04577703,0.033462036,0.0047735893,0.0071103037,-0.021509014,0.12719652,0.04349671,0.060694296,0.06886803,-0.015103736,0.17524149,0.11682517,0.01884912,-0.019161562,0.06388343,0.03655575,0.00051138015,-0.0777584,-0.049172897,0.020889286,-0.06097521,-0.09295648,-0.020028796,-0.045343,-0.0049335626,0.07425029,-0.01629621,0.031114424,-0.02852475,-0.02998161,-0.006086864,-0.011263882,-0.044754647,-4.78419e-08,0.046937387,-0.08838951,0.07198902,-0.006269984,0.025560832,0.0065905433,0.038891967,-0.045189045,0.02570276,-0.119357936,0.0091858655,0.09416168,0.05132522,-0.05140687,0.02434273,-0.016711993,-0.024038821,0.027478272,-0.037856795,-0.052725427,-0.062048823,-0.009192158,-0.19184116,0.048303295,0.009000815,-0.053180363,0.028180486,0.041087147,0.008967142,-0.058996495,-0.009574475,0.057762917,0.07849148,-0.052228156,-0.07103652,0.02071925,-0.0010430998,0.010114582,-0.023647053,-0.04243102,-0.079040974,0.013429532,-0.005552158,-0.02114202,-0.0029479228,-0.0051102717,0.015371778,-0.0038145587,0.009533419,0.016433286,-0.016356707,0.01628506,0.010387521,-0.03486739,-0.050820865,0.05955836,0.011394763,-0.06965256,0.019301856,-0.06259035,-0.0748302,-0.04242737,0.12101304,-0.04175655 +1.19.6.1,"Requires Mg2+. It is composed of two components, dinitrogen reductase and dinitrogenase, that can be separated but are both required for nitrogenase activity. Dinitrogen reductase is a [4Fe-4S] protein, which, at the expense of ATP, transfers electrons from a dedicated flavodoxin to dinitrogenase. Dinitrogenase is a protein complex that contains either a molybdenum-iron cofactor, a vanadium-iron cofactor, or an iron-iron cofactor, that reduces dinitrogen in three succesive two-electron reductions from nitrogen to diimine to hydrazine to two molecules of ammonia. The reduction is initiated by formation of hydrogen. The enzyme can also reduce acetylene to ethylene (but only very slowly to ethane), azide to nitrogen and ammonia, and cyanide to methane and ammonia. In the absence of a suitable substrate, hydrogen is slowly formed. Some enzymes utilize ferredoxin rather than flavodoxin as the electron donor (see EC 1.18.6.1, nitrogenase).",384,1.0,-0.04206812,-0.043227475,-0.114072055,-0.0060999277,0.116539374,0.009135568,-0.033920318,-0.034264002,-0.0223516,-0.08771204,-0.08514926,-0.03837931,-0.042391248,-0.0031021752,-0.04724192,-0.072251074,-0.00718832,0.018355656,0.014049212,-0.029267536,0.016980471,-0.06426077,0.026301779,-0.06311885,0.0068927067,0.018613763,0.019299667,-0.049664993,-0.0540015,-0.0626687,0.028989092,0.005739817,0.026265293,-0.043822393,-0.023148289,0.09768499,-0.039646953,0.0018114799,-0.01604554,0.014170268,0.025263708,-0.024291573,0.01808823,-0.06459003,0.038849194,-0.050626565,0.03110004,0.012243853,0.03716932,-0.01563057,-0.05885564,0.00805485,-0.011964527,0.048334222,0.011532752,0.021926532,-0.049810335,0.006018633,-0.06227231,0.013335133,0.049179677,-0.033460874,-0.007901284,-0.07274957,0.103399545,-0.029104905,-0.007646395,-0.085820526,0.04906844,-0.010626296,-0.016576655,-0.00407525,-0.04743768,0.052862424,-0.013109533,0.046158228,0.033818156,0.008761175,0.09711156,-0.037381046,-0.015579515,0.09369893,0.087606475,0.046961397,0.05373098,-0.021957764,-0.02855739,-0.0044585485,-0.056922637,0.041289877,-0.017703628,0.056283664,0.034923293,-0.014803063,0.0066173896,0.041827828,0.003503947,0.042040486,0.029624423,-0.010907527,0.011610352,0.08238118,-0.097876534,-0.10174313,-0.10183536,0.0072149034,0.026838481,0.120441146,0.028055534,0.02977372,0.005268073,0.026725763,0.045155186,-0.023723608,0.009455167,0.082533196,0.0010399976,-0.040198777,-0.046881884,0.07518333,-0.018272398,0.017121492,0.07947588,0.07241808,0.031079005,0.030842463,-0.12958907,3.8509654e-33,0.052018907,0.059894547,-0.00025172022,-0.005460446,-0.019666268,0.018742407,-0.063540705,0.014064079,-0.0014381746,-0.0303732,-0.011970219,-0.020229049,0.050967343,-0.06745252,-0.017863374,-0.09437168,-0.0027916068,0.0047255675,0.028225902,0.01299326,0.043169834,0.06892217,-0.046470907,0.0889129,0.034031518,0.051141873,0.0010326875,-0.020642202,-0.0030147824,-0.010305525,-0.031937145,-0.11443573,-0.056082122,0.056666974,0.07071546,-0.10502673,-0.06414902,-0.023972176,-0.023143213,0.00018412845,-0.06592273,0.00065116206,-0.05077133,-0.043096133,0.0351587,-0.04712036,-0.032403164,0.0648804,0.0075619854,0.06397826,0.06526786,-0.010791673,0.08336497,-0.014412466,-0.11411488,0.06442019,-0.033235285,-0.010842548,0.080503084,0.020750735,-0.041766826,0.048710305,0.02260081,0.052025724,-0.027847992,0.063974276,-0.038712725,-0.054939505,0.052995887,0.086409636,-0.054697406,0.031786837,0.06872198,0.018968364,0.08358161,-0.02892989,0.0050445003,-0.08231714,0.036888704,-0.007987448,0.014011606,0.036235668,0.03368621,-0.03148095,-0.053991213,-0.07546483,-0.04452097,-0.0029817151,0.04300603,-0.0072493893,0.03086662,-0.08973713,-0.030709662,-0.057874527,0.023736214,-3.3999124e-33,0.10755597,-0.06645074,-0.009599039,-0.07922287,-0.06100923,0.03869852,0.051887102,-0.09668185,0.06264218,-0.017847395,0.09979831,-0.056010593,0.048783742,-0.051070914,-0.050451905,0.024727706,-5.4878205e-05,0.022153331,0.046953224,0.0005774156,-0.0431084,0.08703873,0.008469053,0.0021389984,0.0258458,0.029657442,-0.040439248,0.034313817,0.11147935,0.057942025,-0.014803729,0.04968875,-0.063431524,-0.07316964,-0.015427268,0.024100628,-0.05782696,0.005908712,-0.06587491,0.012022896,0.027744828,-0.022185182,0.04269198,0.08587327,0.040811118,0.017786013,-0.08564366,0.01725512,-0.009628501,0.021007627,0.07304806,-0.042330347,-0.049037494,0.0031379606,0.025176598,0.014108166,0.095814094,0.031368215,0.0133533245,0.07456138,0.009891559,-0.10625305,0.06945238,0.037344698,0.011658037,-0.009032851,-0.012833511,0.11514387,0.019947015,0.038184457,0.07554421,0.005070325,0.16934521,0.11512439,0.016683124,0.0063473135,0.04674464,0.039940286,0.016271366,-0.033572074,-0.052295595,0.019679448,-0.04890658,-0.09467327,-0.0016579574,-0.051942904,-0.00022924981,0.07546272,-0.011318472,0.020131115,-0.018153546,-0.052765522,0.024163356,0.015030249,-0.040553357,-4.6523176e-08,0.05136211,-0.05500621,0.054953407,-0.017206475,0.008199066,0.0054967897,0.013886103,-0.04089098,0.043351576,-0.09528684,0.014770929,0.060075186,0.027486986,-0.063215435,0.04429835,-0.013454182,-0.009548414,0.0076901154,-0.045485627,-0.03690161,-0.028635487,-0.036681186,-0.1902937,0.065434664,0.03694511,-0.06239162,0.030572662,0.03694614,0.026238803,-0.06664391,-0.020528048,0.04266581,0.08099096,-0.041277323,-0.083862916,0.020587647,0.0174966,0.014505423,-0.027744789,-0.03024533,-0.05949183,0.026839107,-0.008193381,-0.030417936,-0.033502355,0.0025233645,0.011708164,0.001106966,0.016713355,0.024861036,-0.01605919,-0.006251496,0.015748564,-0.057942543,-0.068130955,0.09456604,0.02049826,-0.08134077,0.027553307,-0.06785249,-0.06641153,-0.030149411,0.1338604,-0.027667096 +1.20.1.1,NADP+ is a poor substitute for NAD+ in the enzyme from Pseudomonas stutzeri WM88.,384,1.0,-0.094442196,0.026778003,-0.022370443,0.0058959574,0.031026762,0.08884777,-0.11980095,0.09188926,-0.019970587,0.019875899,0.030552527,0.014090229,-0.0813192,0.054245215,-0.06917639,0.03195166,-0.013879227,0.002800868,0.029060267,0.021716591,0.03501963,0.059066948,0.018321514,0.017528506,0.092076704,0.06905588,0.009639532,0.028630916,0.030021407,0.013514397,-0.041149907,0.017260985,0.016385771,-0.13898577,-0.005908053,0.045416,-0.027321175,0.0038305859,0.055602018,0.0051213433,0.04041697,0.00760446,-0.072441295,0.0019537115,-0.047613878,-0.054684564,0.05585934,0.046506,0.08887409,-0.019346733,-0.079909734,-0.0015697618,0.010577639,0.03296974,0.02263992,-0.019197633,0.027681114,-0.035024107,-0.05279143,-0.09913464,-0.026649864,-0.08504014,0.009733396,0.024867237,0.07482865,-0.039960288,0.060825273,0.04073381,-0.01124511,0.016369756,-0.13456582,0.019372907,0.02788867,0.058357608,-0.0023897896,0.010285358,-0.027132887,-0.058651485,0.09688641,0.009604835,0.044584647,-0.0051387446,-0.049458157,0.04412012,0.09132588,-0.027434176,-0.029293964,0.003493566,0.03125736,-0.013870195,-0.012088816,-0.016765967,-0.034788564,0.024101777,-0.13723426,0.04166126,-0.0024854008,0.029908434,-0.036452364,-0.055320077,0.019249316,0.040290974,-0.020029768,-0.08765315,0.0318393,-0.022834804,-0.0009366437,0.10268418,-0.028703108,0.0077287676,0.035081074,0.003427864,0.0037399407,-0.087334104,-0.012755333,0.08488071,0.00494855,-0.035875525,-0.10742485,-0.037921757,0.0024291254,-0.055849485,0.036488995,0.028956922,-0.016507532,-0.0053652674,-0.095067486,1.1485117e-33,0.09790502,0.024824003,-0.08707125,-0.010376044,0.064879455,0.0029060454,-0.087197244,0.010832462,-0.038441807,-0.05327718,-0.02887492,-0.121408574,-0.0022073507,-0.016435914,-0.0021879268,0.00922518,-0.020798407,-0.031222759,0.0070975847,-0.010333725,0.05274762,0.039255872,0.010621597,0.025035108,0.08126954,0.081334494,0.0008770449,0.0354276,-0.053736884,-0.020690091,0.07323175,-0.052375603,-0.15782848,-0.033160698,0.096947916,0.006502444,-0.051121,-0.0931036,-0.0029927713,0.050106965,-0.07145214,0.08880148,-0.0014992886,-0.022205368,0.085503004,-0.09525065,-0.04438937,0.06788731,0.045249935,0.09510117,0.03873879,-0.0034653689,0.05470491,0.00256244,-0.085819826,0.037408557,0.036265697,0.025246765,0.0018572945,0.049876228,0.012462085,0.042044885,-0.013059062,0.035735678,-0.098412156,0.00625957,-0.045057636,-0.04211385,0.09176018,0.038968984,0.019037,0.028121384,0.014792615,0.089591436,0.016704714,-0.08381131,-0.0047649047,0.052015625,0.047020957,0.027278641,-0.0117844455,-0.043242387,-0.04023579,-0.0067653814,-0.06499432,0.017908862,0.03867569,0.0029129793,0.0007459909,-0.023879098,0.07760198,-0.029587073,0.008730605,-0.022324812,-0.011621639,-2.4305339e-33,0.04257379,-0.050694674,0.09054072,-0.030369539,-0.053930208,0.07496785,-0.008641212,-0.07931799,-0.046653662,-0.093564294,0.069890104,0.035750154,0.015621923,0.028670494,0.038646977,-0.003073524,-0.034287374,-0.00082107045,0.004145539,-0.08022333,0.06343805,0.10120663,0.014424176,0.0010911513,0.0313689,-0.07359408,-0.061790887,0.094538905,0.023579847,0.05311128,0.008417522,0.06951832,-0.1509188,-0.02131143,0.024304,0.04254001,-0.040896587,0.038067292,-0.009407114,0.027779154,0.09584884,-0.002030366,-0.06536212,0.061971407,-0.03905105,0.05838244,-0.056531116,-0.07254816,0.012199361,-0.060218107,0.05902436,0.06306441,-0.08109921,0.009644489,0.03561571,0.0074114776,-0.028745031,0.008913925,0.066899516,-0.026035704,-0.048094574,-0.051744077,0.011963754,-0.019292457,0.04719589,0.06534332,0.029653661,0.014681546,0.034916196,-0.050632667,0.06914915,0.037642606,0.025671743,0.053005245,-0.016559793,-0.013190223,-0.060680043,0.02114962,-0.0073147328,-0.015599341,2.2486798e-05,-0.030916382,0.010491388,-0.052967355,-0.023466818,-0.008107675,0.031637765,0.06437263,-0.09319973,0.028105032,0.021994853,0.04722091,-0.00037963295,0.001354621,-0.019860664,-2.330293e-08,0.028682383,-0.030315166,0.018194618,-0.06053634,0.015697565,0.0049141105,-0.05781,-0.027631138,-0.0050606467,-0.0013385563,-0.0011205525,0.100728415,0.01498407,0.043036494,0.040216263,-0.015111295,-0.07898296,-0.017013954,-0.051337663,-0.04854154,-0.046677954,0.03130167,-0.08462639,0.041856073,0.025563871,0.025327729,0.0020950662,-0.051072754,0.06392524,-0.09082996,0.017301409,0.052065156,0.023967208,0.04482702,-0.0521799,0.06090558,-0.011332328,0.023249708,-0.08245703,0.05758348,-0.046089012,-0.13775623,-0.031164747,0.00989595,0.020021837,0.033867363,0.040304966,-0.026661353,-0.058151152,-0.06598189,0.120629154,-0.043585017,0.07227043,-0.08486101,-0.088308245,-0.0070691826,0.0058205575,-0.048076957,-0.02345837,0.008900884,0.009613608,-0.07977891,0.04733177,-0.019645967 +1.20.4.1,"The enzyme is part of a system for detoxifying arsenate. The substrate binds to a catalytic cysteine residue, forming a covalent thiolate---As(V) intermediate. A tertiary intermediate is then formed between the arsenic, the enzyme's cysteine, and a glutathione cysteine. This intermediate is reduced by glutaredoxin, which forms a dithiol with the glutathione, leading to the dissociation of arsenite. Thus reduction of As(V) is mediated by three cysteine residues: one in ArsC, one in glutathione, and one in glutaredoxin. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. cf. EC 1.20.4.4, arsenate reductase (thioredoxin).",384,0.99999994,0.05035697,-0.008837401,-0.041073013,0.01856439,0.11518955,-0.021916293,0.05606348,0.043740988,0.05291882,-0.026332911,0.013086981,0.0128630735,0.012547455,0.01723123,-0.09438708,-0.0797104,-0.073351175,0.011439314,-0.05669495,0.013719342,0.065314755,0.0409386,-0.019137219,-0.026026905,-0.029985137,0.046230175,0.064735204,-0.03716742,-0.041106,-0.039626714,-0.042644333,-0.07328945,0.038340766,-0.01501853,-0.041445345,0.10261949,-0.10512466,-0.004211418,-0.015059462,-0.09772328,0.036766887,0.015492841,-0.06837317,-0.029250197,-0.060663674,0.008549087,-0.021731112,-0.048802108,-0.004234255,-0.007820791,-0.015884228,0.027600026,-0.0482408,0.08237481,0.033703607,-0.052431304,-0.034519766,-0.033070143,-0.091338046,0.002011542,0.04630293,0.031076895,-0.07647438,-0.10673941,0.062425785,-0.024000894,0.09353531,-0.03827512,-0.06301091,-0.049945258,-0.010632389,-0.035910122,-0.021669466,0.02020664,0.0057413015,0.084541276,0.05350437,-0.053766888,0.022179302,-0.04886555,0.07287338,0.052765373,0.12407247,0.043951172,0.039360102,0.003493657,-0.06234593,-0.01279047,0.01624519,0.053765144,0.09609954,0.11824625,0.055466767,-0.076931186,0.10814188,0.05193475,0.05705724,0.056961592,0.0817215,-0.00777675,-0.030501822,0.08813313,-0.15377551,-0.031254273,-0.021124559,-0.021127956,-0.0097262245,0.03606357,-0.005415472,-0.00031309112,0.007736782,-0.011245098,0.05563487,-0.027830198,0.013065572,0.12612176,0.086701795,-0.0072566736,-0.07625887,0.0065425234,-0.02070682,0.04817434,0.11889407,0.08260282,0.012318685,-0.027387593,-0.11845725,3.9971102e-33,-0.0012655604,0.120214775,-0.011417408,-0.024176518,0.027106268,-0.012393431,-0.10144295,0.04517476,0.030603843,-0.030489005,-0.049772907,-0.119660296,-0.015037075,-0.06754454,0.0043360195,-0.068665124,-0.009177479,0.0007700561,0.057337914,-0.055304382,0.01782527,-0.024770748,-0.017209565,0.005489245,-0.037422627,0.04373211,-0.017751945,0.07517635,-0.04149758,-0.031406373,-0.002579069,-0.07065013,-0.116098724,-0.06657021,0.03937852,-0.005229633,-0.07479739,0.04510778,-0.055890914,0.025082842,0.004200224,0.015886663,-0.022617688,0.009434619,0.04997938,-0.06381931,-0.08497194,0.066690646,0.076172985,0.008560167,-0.010315015,-0.04297575,0.110402085,-0.09539618,-0.076899976,0.011573485,-0.024874527,-0.044873662,0.0060980553,0.09431999,0.08876284,-0.033434875,-0.060345523,0.08658829,0.0134037435,0.03800894,-0.06812916,-0.018778631,0.02021501,0.072803885,-0.03791813,-0.026561499,0.10679131,0.0025053483,-0.028613426,0.03616583,-0.10066749,0.007971782,0.026937796,0.004067657,-0.0826905,0.053541828,-0.022202734,-0.004762544,-0.016717138,-0.021348353,0.010583003,-0.022113092,0.027206592,-0.02368865,0.049687453,-0.10022075,-0.13444789,-0.022889243,-0.03341487,-4.7153288e-33,0.07985659,-0.023640098,0.029068343,-0.0696288,-0.027148874,0.06673415,0.077418216,0.050728437,0.007723371,0.0014797511,0.074421845,0.020369483,0.02737359,-0.029732104,-0.0048359027,0.015765782,0.021776386,0.039824635,0.004329589,0.034285706,-0.00795449,0.041630853,-0.018100062,0.024178907,-0.011394232,-0.011577243,-0.012376267,0.041888397,0.06411541,0.048643876,0.023163123,0.06275623,-0.015641749,-0.06086428,-0.038002625,0.056808658,-0.027754512,-0.039448764,-0.046103198,0.030935854,0.05022506,0.040221613,-0.021447599,0.08569804,0.10170503,0.043661978,-0.08590161,0.06490511,0.040249597,-0.04840581,0.059009466,-0.012459397,-0.0023234067,0.038212605,0.057229064,-0.011921599,0.044659447,0.018241929,-0.018841011,0.033107992,-0.04782321,-0.050460126,0.017820135,-0.021541972,0.022712383,-0.024736762,-0.01622998,0.034939773,0.025714926,-0.01925986,-0.031204702,-0.020439006,0.026995033,-0.06213843,-0.057502866,-0.045182146,-0.0077427262,0.034674358,0.017294524,-0.026152957,0.002584017,0.044205815,-0.021189794,-0.056047462,-0.031022687,-0.04643896,0.017321382,0.12644492,-0.06363757,0.024004674,-0.05995101,-0.077713996,-0.018032474,0.044181958,-0.015533477,-4.967659e-08,0.009543849,0.0030726623,0.03400979,-0.054330673,0.018732248,0.04011624,-0.027318666,-0.0043443176,0.04334576,-0.04126508,-0.042698447,0.03483718,0.008999847,0.011709098,0.01685803,-6.818653e-05,-0.044248287,0.06126312,0.012587228,-0.007066705,-0.06899314,-0.0151307685,-0.09211024,-0.03515179,0.050247986,-0.055759955,-0.0035159856,-0.023791263,-0.06359705,-0.040551547,0.013633039,0.027939335,0.0732442,0.010446675,-0.05502273,-0.0054420982,0.005034338,-0.04739004,0.0066438317,0.031787038,0.0018695054,-0.013142278,-0.09187462,0.0053313146,0.016273635,0.04775249,-0.03808168,0.030840065,0.026566995,0.02800398,0.036456835,-0.011733111,0.04015203,-0.07162417,-0.038012736,-0.0033724038,0.03181076,-0.015362727,0.047719,-0.013707891,0.09501698,-0.037258856,0.14186981,-0.05242446 +1.20.4.4,"The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin [1]. It has no activity with glutaredoxin [cf. EC 1.20.4.1, arsenate reductase (glutaredoxin)]. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. The enzyme also has the activity of EC 3.1.3.48, protein-tyrosine-phosphatase [3].",384,0.99999994,0.016404586,-0.03666506,-0.104680255,-0.025441,0.081594706,-0.0024715178,0.033592492,0.09517114,0.03652267,-0.02255407,0.017362164,-0.011236346,-0.0367087,0.0562772,-0.017926386,-0.06687899,-0.06748191,0.01669471,-0.007899507,-0.014723207,0.04247739,0.048431262,-0.00701015,-0.009425671,-0.04777215,0.045651145,0.095045,0.0071913432,-0.050887458,-0.05309654,-0.072862834,-0.05264961,0.041482326,-0.044337705,0.013176182,0.103185415,-0.093750164,-0.06050612,-0.005379828,-0.12915511,0.059930105,0.018095922,-0.024707405,-0.053418737,-0.064201705,0.016474059,-0.0057719643,-0.009483637,-0.00029281442,-0.0141964,-0.06323173,-0.014167315,0.03890278,0.03888375,0.023337228,-0.029230379,-0.063314535,-0.05088957,-0.05471032,0.004552973,0.030121835,0.031441644,0.007827977,-0.07748919,0.033778492,-0.044131625,0.047628023,-0.025737887,-0.039979544,-0.011036609,-0.033166934,-0.06750126,-0.052461006,0.055189166,-0.0046955543,0.06878556,0.08797969,-0.048523203,0.058500737,-0.072973266,0.021561837,0.02703254,0.10727675,0.05607609,0.019708488,-0.024753023,-0.046987146,0.03913834,0.010133183,0.07688226,0.10803828,0.09964053,0.059915118,-0.065782726,0.0659748,0.063500986,-0.04189166,0.05926119,0.028714193,-0.032557994,-0.04318705,0.088126145,-0.13557012,-0.0072509684,0.014162192,-0.047792383,0.0064888843,0.0877842,0.015000479,0.021784874,0.015819382,-0.014580735,0.067682296,-0.059817802,-0.0013149166,0.0724016,0.0375648,-0.036391784,-0.11946665,-0.03656702,0.015643872,-0.0040841224,0.09197019,0.061858024,-0.0040130336,-0.051630978,-0.11435399,3.2e-33,0.02731319,0.064024694,-0.04525737,-0.034894448,0.0062928735,-0.031122163,-0.05891836,0.05141085,0.014107582,-0.070069365,-0.07607119,-0.11337874,-0.06369655,-0.011100168,0.060614925,-0.021287613,-0.029407995,0.049759522,0.062270425,-0.008925373,0.018340046,0.007993534,0.027808342,-0.022726234,0.04332702,0.0623615,0.0027097024,0.037979204,-0.004030749,-0.021459473,0.02395182,-0.108902775,-0.08556564,-0.042020384,0.03186874,0.06321269,-0.10871691,0.03524763,-0.061239857,0.037584785,0.008390156,0.025240408,-0.018939001,0.031642746,0.036376532,-0.042022943,-0.08195264,0.08349111,0.09581159,-0.023247033,-0.017536322,-0.037556097,0.07942874,-0.08283579,-0.052174643,0.0036691995,-0.04672514,-0.012368383,0.02960292,0.065252334,0.029240254,0.013180111,-0.045504954,0.07134831,0.011420763,0.0051624454,-0.032098867,-0.02795376,0.011371961,0.051477186,0.017103981,-0.051953297,0.101830274,0.022297041,-0.010498207,-0.033657167,-0.04921472,-0.021796782,0.011556561,0.0011453185,0.020899393,0.011004646,0.06993197,0.012627601,-0.018984748,0.033925723,-0.028455598,-0.007137424,0.04957629,0.028823331,0.029194523,-0.113086015,-0.14020602,0.076009184,-0.088832706,-3.0120458e-33,0.07200118,-0.035993516,0.068821125,-0.058820177,-0.04825127,0.044213552,0.055810895,0.075563684,0.015475664,0.0205377,0.12744403,-0.024649495,0.042147726,-0.076886974,0.0033809037,-0.011794422,0.018484216,0.035030853,0.04010297,-0.009520527,-0.026924035,-0.011849508,-0.040678788,0.03535104,0.005899666,0.028904334,-0.043789092,0.052400418,-0.00434697,-0.015403639,0.0239258,0.07064546,-0.0071974685,-0.02623317,-0.010716871,0.07200124,-0.040360518,-0.017068077,-0.047387287,0.023949625,0.063292444,0.06031272,0.041846167,0.04307013,0.080081366,0.026693271,-0.07189857,0.01888626,0.018167952,-0.018186906,0.06672338,-0.0035578648,0.016018556,0.055121645,0.04389063,0.007472182,0.025090985,0.038682304,-0.020149311,0.012810932,-0.011765522,-0.094895914,0.014323294,-0.004637789,0.042605728,0.0046905144,-0.05331305,0.06714769,0.009254003,0.0026861755,0.024908576,-0.050717644,0.047246505,-0.052758757,-0.05972708,-0.012701008,0.0046485052,0.02826279,0.044690162,-0.025842203,0.07299208,0.055272397,0.011917561,-0.01839126,0.013300686,-0.0063666943,0.061205264,0.1308241,-0.081922956,0.043811418,-0.056851882,-0.10402297,-0.024893494,-0.008883526,0.0011692977,-4.741951e-08,0.0050990162,-0.061474577,0.02807944,-0.07622619,0.03412055,-0.009499156,-0.014809237,-0.021420304,0.037547745,-0.0010036099,-0.06101683,0.009846635,-0.018927412,-0.03215646,-0.0019453117,-0.0033649406,-0.057585858,0.049004097,-0.0055552097,-0.029589089,-0.057574622,0.00803258,-0.11369856,-0.008215783,0.028459452,-0.021862064,0.0071794875,-0.023348652,-0.030266048,0.008932681,-0.0293475,0.031091861,0.052283186,0.030550936,-0.05920665,-0.012629831,-0.021798346,-0.067823224,-0.0796816,0.054033063,-0.013307786,-0.021037119,-0.031100959,0.005374441,0.033816837,0.008327752,-0.041404054,0.023540623,-0.029410573,-0.04493283,0.090453275,-0.029938087,0.06275075,-0.12034825,-0.07144186,-0.02944888,0.020364095,-0.036149062,-0.004801854,-0.021622047,0.12027823,-0.049492773,0.19676329,-0.006145774 +1.20.4.2,"The product, methylarsonite, is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid.",384,0.99999994,-0.0081610475,0.02354127,-0.09835546,-0.012188494,-0.006024993,0.006547195,-0.005255408,0.049657788,0.035562925,-0.043345854,0.070005715,-0.119455345,0.019100571,-0.04224896,-0.011069424,-0.004614678,-0.12201961,-0.029353019,0.0011962733,0.024076581,0.03296342,0.05048121,-0.013712349,-0.010014783,-0.048724532,0.06956405,0.0063473186,-0.022757253,0.05385486,-0.022448258,-0.007107155,0.024406038,0.0479717,-0.013482861,0.033236872,0.06206196,-0.0005337633,-0.038154285,0.030174589,-0.016599204,0.053461645,-0.028174257,-0.0056155673,-0.06901687,-0.06513543,0.0066747926,0.025594993,-0.06975387,-0.034586433,0.0012909252,-0.023755306,-0.005488798,-0.026288724,0.02520367,0.02931378,-0.022842212,-0.031933673,0.044283066,-0.04936091,0.018851288,0.11149179,-0.020437129,-0.04051018,-0.029482674,0.013052191,-0.0413629,0.05139219,-0.08557488,0.050993476,-0.06845781,-0.05694266,-0.057131585,-0.028908692,0.12212047,-0.0031639568,0.055222467,0.0677687,-0.08333175,0.05131265,-0.08119144,-0.003681229,0.028581798,0.009605167,-0.065078765,0.030453892,0.023008032,-0.021327712,0.03312116,0.002522999,0.0529071,0.048919663,-0.015743712,0.054079425,-0.060480703,0.030979378,0.06289892,0.021315673,0.024810366,0.027599806,-0.013410372,0.0146291135,0.107554585,-0.13468915,-0.010193709,-0.015032388,0.02609199,-0.015615642,0.055433318,-0.01391519,0.016841881,0.006133757,-0.021643775,0.001510885,-0.0055403607,-0.02484457,0.119112484,0.021638481,-0.018517185,0.014808687,-0.033739902,0.005008486,-0.019223832,0.042083126,0.035791174,-0.0033086864,-0.03750153,-0.0660316,-1.0952336e-34,0.0013637848,0.089308545,0.018281033,-0.058927074,-0.038457733,0.04003129,-0.07229059,0.074283384,0.050767284,-0.13307846,-0.027388973,-0.12919614,0.022242527,0.07504627,-0.058902144,-0.03226654,-0.07869993,-0.023688078,0.056308422,-0.06576306,-0.03800042,0.035745367,0.031553194,-0.040276937,-0.060285512,-0.027927903,-0.03567759,0.03383635,0.07241865,0.00027317842,0.0137523385,-0.07987283,-0.058557995,-0.022154136,-0.017997002,0.10759609,-0.006539382,0.015688624,0.050516963,0.12420792,0.076993145,-0.011121654,0.011050435,-0.0258085,-0.046859577,-0.027289608,-0.08103671,0.031104248,0.033184692,-0.016237782,-0.028626993,-0.03437609,0.041426636,-0.06496829,-0.04019405,-0.0126319835,-0.02787185,-0.06503851,-0.08257462,0.045992676,0.022396632,-0.012780092,0.05033443,0.07091818,-0.05540518,-0.08130931,-0.060656674,-0.023917938,-0.004047985,0.0044978857,0.002410193,-0.010312837,0.13901404,-0.039620496,0.02911111,-0.014154826,-0.09030446,-0.00519131,0.006643582,0.0781874,-0.02769026,0.06253781,0.025163408,-0.023008274,-0.04425355,0.038039263,-0.016834341,-0.019220915,0.005158542,0.031054601,-0.06951819,-0.06448982,-0.027582426,0.04994458,-0.07049638,-2.3736232e-33,0.033951297,-0.018179055,0.05474195,-0.061823998,-0.005029515,0.04108105,0.05947259,0.0067034336,-0.08678155,-0.027206432,0.12481714,-0.011666838,0.08750789,-0.044595536,0.06343189,0.027643805,-0.014673793,0.080945194,0.025397666,0.055868056,0.016373964,-0.020753514,-0.03296134,0.104410104,0.042182304,-0.026627265,-0.010493523,-0.020021794,0.1003264,0.04034724,-0.0513669,0.0026285278,-0.05480806,-0.046208706,-0.0050869733,0.049677365,-0.021353286,-0.046581414,-0.057642356,0.012011983,0.023850553,0.05108685,-0.064911716,0.08421991,0.07519314,0.03217057,0.012347892,0.018591607,-0.009824966,0.031264335,0.023133438,0.0026125142,0.0038703855,0.08391157,0.025836183,0.08230027,-0.01735345,0.0809765,-0.05361167,-0.03607929,-0.10438656,-0.038284738,-0.03316949,-0.08320237,0.078580625,0.020021401,-0.072114296,0.03348737,-0.012716864,-0.00964268,0.10223474,0.004620047,-0.068586335,-0.038882494,-0.07309357,-0.09342173,-0.07222287,-0.07774308,-0.055906754,-0.07074965,0.031083772,0.015696194,0.023434674,-0.0292409,-0.050518543,0.0008303865,0.01190353,0.07284681,-0.07780075,0.03122437,-0.08002137,-0.0091054095,-0.07485385,0.07351422,0.03155545,-3.502126e-08,0.024116311,-0.12037944,-0.0061859963,0.0035072207,-0.013364803,0.07267667,-0.05673329,0.017513685,0.015111836,-0.0020057142,-0.039025415,-0.011622198,0.014493276,0.07809483,-0.012713731,0.021478217,-0.017216267,0.08110575,0.0066594374,-0.01597554,-0.08835492,-0.004956787,-0.0073299813,-0.009970121,-0.056318175,0.0045299386,0.017104479,0.07766809,0.015573057,-0.0783414,0.01886978,0.011329131,0.03663774,-0.017722389,-0.004646663,-0.006999705,0.07792072,-0.042219076,-0.04602278,0.02482987,0.026633091,0.033195585,-0.049301904,0.04430014,0.085103884,0.010838225,-0.016322762,0.079954065,0.006415751,-0.027884973,0.021885205,-0.011898732,0.0524084,-0.08935228,-0.021938834,0.0050829183,-0.09302994,-0.0179309,0.05121083,0.07938906,0.0748504,0.08604332,0.1630131,-0.0713527 +1.20.98.1,"Contains a molybdopterin centre comprising two molybdopterin guanosine dinucleotide cofactors bound to molybdenum, a [3Fe-4S] cluster and a Rieske-type [2Fe-2S] cluster. Also uses a c-type cytochrome or O2 as acceptors.",384,1.0,-0.037848838,-0.09725803,-0.12765184,0.023271093,0.092849545,-0.017296793,-0.053305052,0.0050455783,-0.010315399,-0.116173595,0.055692974,-0.08405482,-0.06705898,0.047802586,-0.06161616,0.011388524,-0.036734752,0.014593814,0.09006673,0.017999917,-0.021485772,0.009359643,0.091778986,-0.018982533,-0.05410709,0.045543414,0.022193553,-0.056640197,0.062394843,-0.071163565,0.014852891,0.02946958,0.028504882,-0.0030881849,0.028222237,0.07228971,0.04010706,0.012154836,0.039445613,0.06273771,-0.0065768925,0.042433295,0.07241993,0.02366312,0.019873863,-0.027232986,-0.05932602,0.0037102287,-0.02670991,-0.04182269,0.04094296,-0.057578903,-0.067853786,0.08512233,-0.0035629678,0.016878555,-0.09244599,0.00845027,0.08496744,0.068710096,0.07735479,0.011946553,0.10411305,0.00789956,0.076283485,-0.0071153278,0.04394761,-0.063638024,0.03645991,-0.08276315,-0.04510134,0.026611937,-0.009504702,0.009830102,-0.025072144,0.11207378,0.009014832,0.028961273,0.06431391,-0.04150741,-0.02679451,0.02271168,0.10826289,0.1059719,0.09620651,-0.034192577,-0.06467308,-0.00078521384,-0.06996002,-0.028042475,0.051249146,0.0012354454,0.0015322856,-0.05142709,-0.07072035,-0.015500572,0.012428182,0.014778906,-0.025771175,0.04850955,-0.051384382,0.07399861,-0.007011697,-0.050337397,-0.06496006,0.008142482,-0.021620788,-0.006244782,0.056290716,0.042014446,-0.028622525,0.10376249,-0.004631736,-0.042662043,-0.0067626783,-0.053323824,0.029852835,0.03127985,0.08189744,0.04106094,-0.0009034353,-0.01831564,-0.059276894,-0.01765754,-0.05721366,0.053652674,-0.07528344,6.5164036e-33,0.03557496,0.019777682,0.035612736,-0.01574754,0.0036631166,-0.0032154159,-0.05941115,-0.036534768,-0.05237991,-0.01328822,-0.021936173,-0.030137053,0.030265983,0.05238741,0.042315632,-0.02655125,-0.08832722,-0.053317696,0.052434538,-0.11105015,-0.0075059948,0.09281413,-0.01819252,0.030140521,0.06570992,0.0150722265,-0.05066272,-0.017339569,0.056174457,0.0155255785,-0.0048520183,-0.075915486,-0.11685729,-0.030086908,-0.021121772,-0.053000577,0.0050051007,-0.12978445,0.010379724,-0.022576444,-0.094906874,0.009030232,0.0008640307,-0.10690417,0.073102966,-0.01090718,-0.017237948,0.03528537,0.032387443,0.013034273,-0.024659244,-0.112728015,-0.055051852,-0.011150979,-0.06557748,-0.053615425,0.0010962758,0.0018201036,0.042563032,0.06483681,0.010956798,0.011946327,0.022678433,-0.022848677,0.009078963,-0.009906514,-0.08433801,-0.073977955,0.024815133,0.029473532,-0.013481839,0.024925187,0.04884355,-0.0358191,-0.06880644,-0.08066092,0.009740428,-0.06948794,-0.014411918,0.022413502,-0.01690147,-0.03863836,0.021473609,-0.045787476,0.004599662,-0.0068795253,-0.05311177,-0.10993784,-0.023029622,0.028887331,-0.029827932,0.041310348,-0.016706074,-0.011669999,-0.029373782,-6.3507456e-33,0.08513727,-0.06677305,0.0809757,-0.092366286,-0.06918172,0.043180518,0.0041039237,-0.033945385,0.05578076,-0.04870495,0.06925944,0.0072020907,0.062028322,-0.10396766,0.016376711,0.00538735,-0.02054329,0.10557171,0.059651338,0.007786862,0.050729007,-0.013091485,0.033637267,0.050016586,0.07629271,0.073067635,-0.04210652,0.0015227395,0.030614935,0.05472954,-0.06252166,-0.022621777,-0.06455176,0.0063411337,-0.029577553,-0.06308322,-0.029241981,0.0217722,-0.024099048,-0.04684945,-0.016926197,0.053763706,-0.023319308,0.117408045,0.04127445,0.055878926,0.0012761641,0.035261426,0.048994973,-0.0077038025,-0.042782523,-0.089883186,-0.05817844,0.05565697,-0.022505064,0.06745246,0.0035958237,-0.04484348,-0.021679407,0.006318661,0.0045977826,-0.07159075,-0.027048517,0.005130401,0.08040017,0.022409916,-0.008534385,0.11137538,0.07325331,-0.015799634,0.029698027,0.03297176,0.08086389,0.0150106475,0.0049468162,-0.0032489875,-0.02161401,-0.018242404,0.00078506005,-0.038724378,0.0054821987,0.035072904,-0.026316704,-0.029949633,0.09159815,0.019625597,0.030105585,0.10193955,0.061894313,-0.008544454,-0.044044096,0.047645964,0.0148130795,-0.010961874,0.040216733,-3.9579838e-08,0.051351577,-0.11599579,0.027335554,-0.07011485,0.0374924,0.041514657,-0.02410738,0.03354326,-0.08368466,0.012435753,0.0790251,0.067302644,-0.029063344,-0.075801335,0.08291779,0.075145766,-0.041089445,0.03027695,-0.01422945,0.0012788955,-0.032019477,-0.04430007,-0.028874116,0.10514268,-0.033937994,-0.030709978,0.009780299,0.04391574,-0.024906086,0.063897096,0.030424904,-0.041848082,0.049146567,-0.012361051,-0.026287347,0.022932975,-0.025409788,-0.03521022,-0.058589265,-0.018003492,-0.025358733,0.01393851,-0.038645156,0.00842261,-0.00911822,-0.020005975,0.00160841,0.08800577,-0.021566898,0.02760227,-0.007076098,-0.07205752,-0.015258024,0.02803459,-0.13252719,-0.030577496,-0.0653634,-0.04794536,0.03885178,-0.08904479,0.024508867,-0.027989637,0.12894955,0.01621594 +1.20.99.1,"Benzyl viologen can act as an acceptor. Unlike EC 1.20.4.1, arsenate reductase (glutaredoxin), reduced glutaredoxin cannot serve as a reductant.",384,0.99999994,-0.045166615,-0.027206391,-0.08476415,-0.0109097045,0.07509658,0.030930365,-0.016579501,0.080510005,0.025181782,-0.10394147,0.048620168,0.022534424,-0.018687505,0.050818123,-0.030187769,-0.026957883,0.003354735,0.046535388,-0.04044646,0.00932636,-0.07406644,0.02544997,0.00014191639,-0.039266296,-0.049149033,-0.022417821,0.019687967,0.0024959913,-0.029125921,-0.07772838,-0.0027744726,-0.056726772,-0.0042556473,0.026655326,-0.058713403,0.012116793,-0.13622004,-0.051585574,-0.05257962,-0.039848924,0.00052612263,0.0048346,-0.024468636,-0.021285744,0.016530294,-0.00994074,0.0143501405,0.015699191,-0.029475855,-0.07112453,-0.004137642,0.013487059,-0.0022993702,0.06924102,-0.06546877,0.04179006,-0.12895298,-0.08641897,-0.04664401,0.00912503,0.01832108,0.02154924,-0.03222867,-0.1134061,0.015248213,0.00312721,0.06037863,-0.037458356,-0.03711284,-0.0057066604,-0.0012711963,-0.05760693,-0.024239948,0.028092433,-0.017861778,0.050829217,0.0049093077,0.05578722,0.08616604,0.015450631,0.0065118987,-0.026564071,0.056500755,0.05932379,0.04271713,-0.0063509787,-0.026051091,0.00916584,0.0033088883,0.07577793,0.05958916,0.018378453,0.051284287,-0.024495272,0.02024833,-0.028650178,0.036990717,0.028336888,0.016178157,-0.025674975,-0.045332007,0.045878217,-0.06881488,0.003087003,-0.011342831,-0.0036436233,0.05174914,0.06395782,-0.020518135,-0.062213987,-0.021804882,-0.050338626,0.08640259,-0.0293542,-0.05308934,0.06410651,0.011975986,-0.08682116,-0.0827191,-0.008912658,0.03067987,0.009791848,0.072300315,-0.04006686,-0.017179398,-0.016082631,-0.06420455,3.7891737e-33,-0.045276187,0.04027448,-0.00971299,-0.00037245164,-0.014474778,0.06480102,-0.10807085,0.029701963,-0.03962728,-0.12856102,-0.1116783,-0.073401615,0.02045126,0.09213674,0.03389797,0.015897213,0.0013856558,0.008462316,0.027277846,-0.09620794,0.088346496,0.05159587,-0.01854299,-0.026233591,-0.038624097,0.012042656,-0.027135177,0.056399673,-0.032555144,-0.010852604,-0.070353545,-0.0033531436,-0.019303862,0.055891182,-0.004274378,0.09203646,-0.0354864,-0.047076136,-0.013181309,-0.038923398,0.01196596,0.09051814,-0.1062856,0.010809958,0.10239092,0.0046061547,-0.063048,0.022250883,-0.01738641,0.03756819,-0.018593779,0.03617908,-0.02414093,-0.07972925,-0.00012646372,0.052710112,0.022662917,0.09230986,-0.01852684,0.022618204,-0.0092812115,0.07626443,-0.029193096,0.034648377,-0.014185627,0.05167592,-0.050731327,-0.04516101,-0.09085143,0.05215978,-0.005413761,0.02827086,0.03637163,0.046212174,0.021581365,-0.12600827,-0.0238017,-0.021461267,0.03890899,-0.060517907,-0.08717343,-0.020183263,0.007893686,0.024202457,-0.026732918,-0.038490064,0.026645457,-0.017024225,0.09406684,-0.010241889,0.04511115,-0.073370054,-0.025409285,0.014513813,0.023674319,-4.1258856e-33,0.054447055,-0.03410616,0.035550144,0.036627088,0.05023468,0.108803906,0.078297295,-0.029363234,0.06772708,0.042076066,0.076777294,0.008062767,-0.0028416421,-0.010829681,0.0095772585,-0.03311547,-0.007892528,0.003693636,-0.026049744,0.015895592,-0.11477119,0.025942583,-0.009640234,0.023062563,-0.015842319,0.05180035,-0.015050713,0.080981284,-0.015237801,-0.0062012053,-0.016589722,0.065452576,0.008804937,-0.069263466,0.033390194,0.109183945,-0.03547864,0.03621197,-0.060173072,0.023921067,-0.005668463,0.014241618,-0.05392926,0.082493246,0.06287817,0.010338724,-0.022262007,0.009816091,-0.034754254,-0.14122717,0.069867186,0.032687083,0.07701035,0.040537022,0.07308259,0.0054819956,0.09579261,-0.06365299,0.0010713295,0.05200313,-0.00439608,-0.05407653,0.010148186,-0.06320721,0.07028181,-0.08456854,0.034433983,0.13305534,0.06755963,0.011446765,0.10486689,-0.034470413,0.10891852,0.031972133,-0.004517161,-0.029962922,0.019086197,-0.0072775874,-0.00058216625,-0.09430755,0.028578384,-0.0053437385,0.05319985,-0.045080625,0.030476348,-0.022845041,-0.012269993,0.054931406,-0.027438251,0.056130234,-0.029246889,-0.049946062,0.013579715,0.029354522,0.03526232,-3.7449237e-08,0.06797257,-0.002965235,0.009991075,-0.057107862,0.005725657,-0.01714833,-0.054277744,-0.04981649,0.03294928,0.04949582,-0.066634685,0.046536867,0.011729358,-0.04157093,0.0147105465,0.025665034,-0.05698987,0.07183956,-0.0346879,0.11905569,-0.11096997,0.07458377,-0.13565212,-0.05844543,0.0048370026,-0.03415856,0.015176279,-0.009685285,-0.010387273,0.0044218074,0.04571748,0.06316191,0.07912816,0.08239868,-0.09161707,-0.032019917,0.060402807,-0.0052583492,-0.05686539,-0.0014961335,0.0727786,-0.06372054,-0.05900122,-0.008338854,-0.024146656,0.027575672,-0.014336077,-0.09149719,-0.0011675606,0.020723265,0.017353516,0.017146187,0.041824598,-0.028175604,-0.052393015,0.02425782,-0.009308113,-0.009312862,0.024078397,-0.10654771,0.05142165,-0.057097763,0.15372923,0.059074536 +1.21.3.1,"Forms part of the penicillin biosynthesis pathway (for pathway, click here).",384,1.0,-0.048827186,-0.029001044,-0.04771533,-0.0447425,0.040290203,0.014467969,-0.04228704,0.05667634,0.09430848,0.017297916,0.028826479,-0.016729323,0.024900507,0.052507203,0.0016907611,0.019277016,-0.16159223,0.03515545,-0.01440435,-0.04104534,0.089725874,0.10994927,0.014260399,-0.014456696,0.054216117,0.0064999093,0.074088685,0.021694165,0.078251116,-0.00214373,0.036875986,0.005804696,0.007731518,-0.063296475,0.06706075,0.044889987,-0.07035837,-0.026556876,0.15776171,0.021656599,0.058139585,-0.01932276,-0.021192167,-0.0089716315,0.0025015408,0.044359036,0.025089782,0.016220031,0.0019452298,0.027908912,-0.01773308,-0.06669998,-0.040641382,0.06649538,0.07347699,0.034417797,-0.056923274,-0.108137466,0.020931864,-0.03647879,0.028959345,-0.01891225,0.003702267,0.032488786,-0.07420066,-0.016184721,-0.0059723486,-0.03563125,0.052634012,-0.057609215,-0.039054822,-0.049517754,-0.0041372087,0.025112597,0.005856087,-0.028645433,0.026245145,0.035576556,-0.038853597,-0.049106207,0.06309508,0.017104259,0.0013503255,0.10204559,0.06794478,-0.041907627,0.065850295,-0.0016937433,0.06568213,0.028160335,-0.0018885669,0.014058249,0.030309025,-0.048787463,-0.0605159,-0.028434448,-0.0070557455,0.03021327,0.0198555,-0.003005816,-0.03346375,0.034262445,-0.026084196,-0.014365748,-0.03995492,-0.045557454,0.020483498,0.10269345,-0.061165795,-0.034346804,0.00027925303,-0.04462465,0.024054613,-0.02540227,-0.017971393,0.028521864,-0.023607736,-0.025708616,0.024700249,0.10355358,-0.033697363,0.008293872,-0.034274947,0.027705463,-0.06154255,-0.02334817,-0.102733016,-4.7088407e-34,0.024467822,0.07532454,-0.024092998,-0.044758074,0.031051327,-0.0070862863,-0.01369635,-0.08537021,-0.008730882,-0.0373253,-0.058926817,-0.09320271,-0.006193286,0.06725096,-0.05948319,-0.04341416,-0.003728282,0.050685834,0.006589054,0.04873074,-0.041111864,0.090291284,-0.053732745,-0.024646735,0.06286236,0.018302437,-0.004532108,-0.0010938977,0.023248143,-0.022312356,-0.031288303,-0.014162872,-0.0581143,-0.040170398,0.055844117,-0.022617703,0.015474177,-0.049872976,-0.011464163,0.056067806,-0.009632464,-0.010771651,-0.061524265,-0.00952766,0.015041857,0.05887184,-0.099439144,0.09190267,0.059286177,0.022981301,0.08425194,-0.021510225,0.097042836,-0.049405064,-0.045747623,-0.025035001,-0.109566145,-0.03623906,-0.004468358,0.020039719,0.04366301,-0.024080904,-0.043847498,0.06591625,0.013234726,0.022956036,-0.07723029,-0.07094917,0.016736446,0.029415708,-0.114097714,-0.008021599,0.03119622,0.042526037,0.065918125,0.010194015,-0.118264146,-0.053110156,0.034350317,-0.004098184,-0.073846795,-0.0067529576,-0.033276275,-0.040463947,3.2771597e-05,-0.03242371,0.0039389427,-0.094727024,-0.049670693,-0.029436918,0.02305592,-0.063070215,-0.10970639,0.049948856,0.03203105,-2.0456691e-33,0.07641899,-0.016840843,0.0028324618,-0.05355527,-0.10890874,0.10543947,-0.0076655843,-0.069383495,0.13455015,0.07151248,-0.005789385,-0.012096219,-0.03668475,-0.031913415,-0.07635185,-0.04659996,0.025647711,0.120819144,-0.02760732,0.0031080453,-0.02832362,-0.033521548,-0.00044324461,-0.033980608,0.017336082,0.04981586,0.013550123,0.0637126,-0.0034831024,0.06842436,-0.03453051,-0.0112456335,-0.05594688,0.006150163,-0.07211184,0.122917935,0.022473508,-0.07018516,0.034687307,-0.059287906,0.038689263,-0.05525857,0.09206141,0.10327903,-0.013848054,-0.02043971,-0.030429486,0.09280357,-0.044026386,-0.1107966,0.030287798,-0.03699196,0.02375695,-0.0072878078,-0.020444304,0.026971836,-0.005110919,-0.048871968,0.06748339,-0.018724525,-0.0021433437,-0.02668506,-0.0092688585,0.041446846,0.02163033,-0.03185502,-0.024002561,0.06351342,0.061799318,0.0041622,0.036566373,0.07339822,0.03705704,-0.0005839814,0.01006468,0.023214212,-0.04178838,-0.07724137,0.042253915,-0.017423486,-0.003029497,-0.03921579,-0.042764258,-0.022173587,-0.08054153,-0.023156684,0.05301239,0.06968174,0.0077372757,-5.4861797e-05,-0.024188407,0.027430966,-0.0148269655,0.11406811,-0.014901294,-3.3076013e-08,0.06392527,0.010251552,0.034323487,0.0061563863,0.0031835637,0.06027049,0.023547545,-0.0073230546,0.052195333,0.008816712,-0.046181202,0.05067759,-0.010567459,-0.030851627,-0.020991044,0.11836974,-0.08687922,0.027193986,0.004175543,-0.030244645,-0.040343683,-0.033790946,-0.07103127,0.031984616,0.06149514,-0.10805716,-0.0014734184,0.05377638,-0.062208254,-0.013402573,0.05554238,-0.03624405,-0.029437147,-0.074120305,-0.014256289,0.044701263,-0.076421075,-0.084924705,0.06477076,0.017501662,0.0134461215,-0.028730743,-0.056396887,-0.020472609,-0.013153894,0.062029682,-0.052354284,0.016488709,-0.094945215,-0.05403906,0.059792925,-0.008500531,0.010070274,-0.030919963,-0.109150976,0.025614392,-0.019572698,-0.05582626,0.017404595,-0.047096137,-0.048858803,0.120178975,0.14118506,0.042834286 +1.21.3.2,An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine.,384,0.99999994,-0.06881967,-0.050384626,-0.07737733,0.07522059,0.06593925,0.07590365,-0.0055531985,-0.00790678,0.05390501,-0.058916796,0.0053097457,0.005231431,-0.006706988,-0.08163074,-0.034096185,0.0359629,-0.06620533,0.06842449,-0.062294863,0.04457331,-0.026933568,-0.00780273,0.04067087,-0.050988577,0.0050479323,0.08308058,0.020484196,0.008502511,-0.015766133,0.00022429944,0.07455652,0.095465496,0.075801186,0.008268712,-0.015521941,0.057076328,0.053600557,-0.06913929,0.021523586,0.03957265,0.021431297,-0.0130910445,0.0028285056,-0.016864125,-0.024756227,-0.07563772,0.10449916,0.062427096,0.060831714,0.043492205,-0.08241308,-0.002256471,-0.036398184,0.014831134,-0.028830837,0.023681788,0.13564196,0.029829435,-0.04120324,0.042168356,0.0011605653,-0.06301709,0.00023876963,0.01199613,-0.013040328,0.018770844,-0.0047451686,-0.09169861,0.030252097,-0.04497496,-0.008840644,-0.016671441,-0.079865225,-0.00566709,-0.013691449,0.07294828,-0.009229436,-0.0951868,0.040446267,-0.015334841,-0.082278766,0.07922483,0.08437576,0.06284121,0.05090018,0.035767347,0.022244046,0.015211124,-0.06838849,0.043179955,-0.0037667085,0.058045432,-0.0099113975,-0.007602036,-0.0029125507,-0.025375267,0.13453154,0.087007515,-0.034342676,-0.0028882164,-0.012674518,0.04386513,-0.09028583,-0.09595549,-0.08442378,-0.02143493,0.049486626,0.049000144,-0.054504544,-0.008946356,0.039672654,-0.019863252,0.015838508,-0.049879402,-0.059218813,0.04615872,0.0864025,-0.028637068,-0.042241298,0.036692034,0.0075565316,0.004450782,0.09386589,0.020138295,-0.0967163,-0.031811547,0.015348878,-2.9825345e-34,0.019210674,0.007732428,0.043957442,0.0056185257,0.0037399605,0.026623154,-0.10233475,-0.01187528,0.013443821,-0.013130374,-0.04296823,-0.03108134,0.00370557,0.019856108,-0.1028271,-0.039977025,-0.061544463,-0.078605406,0.05127415,-0.061890647,0.030961717,0.10030807,0.023236185,-0.026177429,-0.058530867,0.034108493,-0.020956196,-0.038112953,-0.021759829,0.02394895,0.020466184,-0.12553795,-0.11443792,-0.06581244,-0.10238869,0.017467301,-0.048653543,-0.0034451338,-0.038644224,0.06019131,0.07077447,-0.010370626,0.0017036042,-0.03746678,0.031404085,-0.0362827,-0.051051762,0.044258222,-0.007955062,0.03388528,0.010446573,-0.0032475712,0.084676236,0.05005029,-0.08737681,-0.06641368,-0.064298145,0.00548454,-0.0055846013,0.112361744,0.06565868,0.044125948,0.05407362,0.049723558,0.0076737665,-0.05231571,-0.0036364137,0.044856105,0.03893639,0.036717527,0.06468169,0.040294223,0.09054783,0.05072521,-0.008997194,0.0025392247,-0.019850623,-0.061573572,0.053676467,0.03996431,-0.010846197,0.0035674046,0.033537593,-0.022807103,-0.16034539,0.054444782,0.016969355,0.017035417,-0.09454242,-0.015981635,-0.046922818,-0.0062541654,-0.035853676,-0.058479108,0.0020853153,-1.48159675e-33,0.032593496,-0.047650144,0.039905798,-0.08423433,-0.0843442,-0.03307699,0.03682163,-0.032583702,-0.012906078,0.035970893,0.1139049,-0.048637282,0.037409306,-0.067260996,0.031454086,-0.0011089123,-0.058956698,0.024457347,0.043180853,0.06171168,-0.0856843,-0.00094184757,0.014001806,0.074367195,0.010083296,0.017468013,-0.021182291,-0.05719966,0.07896862,0.16223478,0.0943733,0.047896784,-0.02856864,0.001259779,0.046071544,0.042364176,-0.09282435,-0.025143627,0.0048248866,0.0037259997,-0.019985957,-0.042506266,0.028658023,0.028222479,0.09769754,0.018212618,-0.10554409,0.013659195,-0.05993311,-0.009948002,0.05465798,0.038879417,-0.041455433,0.045763195,0.0358274,0.04862664,-0.030371161,-0.020739207,-0.0034039617,-0.0027410428,-0.031347524,-0.012353471,0.011696271,0.0026837732,0.04060201,0.042086247,-0.028176522,0.005327151,0.02094577,-0.035324126,0.058777746,0.031797443,0.029600818,0.041789908,0.0074170264,0.02069447,0.0071339635,0.0655931,-0.06584009,-0.023007803,-0.033397075,-0.040132385,-0.042654797,-0.05127905,-0.020844106,-0.008402573,-0.017288225,0.015776306,0.06403098,0.006484453,-0.07017761,-0.08896078,-0.15112922,0.024269868,0.026220504,-2.317631e-08,-0.029797344,-0.047545016,0.12061695,0.027474277,-0.08133434,0.02177491,0.030199397,-0.019105684,-0.026065601,-0.00972913,0.046613682,0.027739894,0.03106232,0.016862847,-0.0075947177,0.024181318,-0.04868797,0.014030298,0.025135385,0.0030927386,-0.06238867,0.022609776,0.0074846325,-0.027156062,-0.060687967,-0.06948941,-0.059149526,-0.03216721,-0.0019032402,-0.07660546,0.10269725,0.0125662815,0.02066054,0.014379423,-0.07221828,-0.022112977,-0.042496238,-0.0017861086,-0.029016843,0.035711426,-0.06940422,-0.06587904,-0.02409752,-0.045828626,0.013990227,-0.04493483,0.0025539105,0.09941201,-0.017498696,0.026544394,0.0629524,0.037369866,0.06318896,-0.009915113,-0.059922118,0.03358689,-0.034700356,0.020044396,0.062237,-0.065250196,-0.056982826,-0.018530337,0.07718342,-0.058051042 +1.21.3.3,"Contains FAD. The enzyme from the plant Eschscholtzia californica binds the cofactor covalently [3]. Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)-tetrahydroprotoberberines. The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants.",384,1.0,-0.04958237,-0.0584769,-0.17959669,-0.060547583,0.08346636,0.13405298,-0.04154221,0.056597125,0.066236176,0.049047817,0.032707043,-0.06824784,-0.01790874,-0.024789458,-0.10978213,0.03358168,-0.1046865,0.0055895494,-0.004127966,-0.018103592,-0.04080092,0.05017378,-0.009976252,-0.00064284203,-0.013004337,0.022196319,-0.017432895,-0.057595197,0.028385099,0.0058754967,0.020231979,0.10087299,-0.0418337,-0.036305435,-0.02769457,0.07600203,0.0138896145,-0.01096416,0.061698746,0.03203932,0.0534193,-0.01024624,0.012823315,-0.018109968,-0.04410862,-0.0084295785,0.0482033,0.089774616,-0.012523628,0.010295619,0.028469903,-0.014233715,-0.03159611,0.03769554,-0.047544125,-0.008613723,0.05536603,0.058241237,0.00750921,0.049917493,0.12954679,-0.023392366,0.0032809938,-2.5312465e-05,0.034054007,-0.05928337,-0.054374747,-0.0400023,0.044026103,-0.025463477,-0.025273772,-0.054905176,-0.01924264,0.052937925,0.019724086,0.030121233,-0.028907357,0.0036440035,0.04023974,0.020917684,-0.001330156,0.004685487,0.01518181,0.10468666,0.04396324,0.028882984,-0.013029528,0.07204208,0.054671958,0.0056697973,0.03194317,-0.037817203,-0.0061057596,-0.025156172,-0.17526974,0.0381175,0.00237624,-0.032147277,-0.03911118,-0.03470054,-0.05856773,0.019997815,-0.052321143,-0.0936779,-0.089232974,0.0015554627,0.00712986,0.038753822,-0.062444333,0.033197455,-0.024925804,-0.035484042,0.0426087,0.009720914,-0.0689932,0.074560486,0.009999311,-0.122542545,0.019506974,-0.005502006,0.01175852,0.0523279,0.02041913,0.03118601,-0.029281242,0.004256937,-0.101969324,2.6099716e-33,0.057586517,0.033100855,0.02006867,-0.007926477,0.06614833,-0.038378276,-0.059883833,-0.013023846,-0.04023989,-0.043334004,-0.08527058,-0.05451274,0.08210701,-0.0162727,-0.04436726,-0.0064955107,-0.08367562,-0.08765499,0.052326385,-0.08506378,-0.016198907,0.11800596,-0.08919078,0.036458284,0.020677196,-0.018422527,0.008825453,-0.00937412,0.08125274,0.0003615394,-0.0048867175,-0.07170674,-0.10807218,-0.00079994154,0.0044600717,0.039877806,-0.026171569,-0.021443274,-0.018659556,0.038202237,0.06576237,-0.0003424565,-0.01923499,0.0017372459,0.059255004,-0.0704322,-0.070441045,0.03616669,0.04873008,0.04402257,0.0700039,0.009600773,0.07976643,0.10325149,-0.11514566,0.05232315,-0.075299636,-0.018784573,0.0043262444,0.045448918,-0.045860488,0.0017941388,0.000117518684,0.023951374,0.056232892,-0.0114591485,-0.00926393,-0.02665011,0.0073896954,-0.008963182,-0.075404905,-0.024827084,0.06981035,0.037385464,0.017384293,-0.016735544,-0.0012221368,0.007889848,0.023121145,0.023516802,0.012278429,0.01816594,0.035065386,0.034101587,-0.07727289,-0.040326465,-0.053705644,-0.039023146,-0.06300956,0.032207917,0.018593038,-0.050158877,-0.032330915,0.02293038,0.0058709206,-3.8153237e-33,0.046818245,-0.0736516,0.11315141,-0.04613906,-0.0070756837,0.06706635,0.02156247,-0.06761172,0.0011465972,-0.025663808,0.06341012,-0.0019554705,0.009663358,0.008430875,0.014674297,-0.02805023,0.024214834,0.06573407,0.045749806,-0.059168596,-0.045691174,0.049734835,-0.020166155,0.02906039,-0.054198377,0.0065281736,0.072163895,0.025442075,0.020635024,0.10203223,0.08007685,-0.07837222,-0.10462625,0.0035003426,-0.02963714,0.024292791,-0.037742343,-0.009913431,-0.028455758,-0.020070715,0.024127055,-0.007457255,0.048116725,0.053107526,0.11167409,-0.01161223,-0.11713097,0.048239667,-0.044401616,0.0025119763,0.04633141,0.03404964,-0.038440067,-0.0036990708,0.087648265,0.02434728,0.10298418,-0.032882165,-0.0305641,0.026931819,0.03864846,-0.030566247,-0.06719967,-0.032429654,0.100036,0.003666382,-0.06286609,0.08541179,0.07730051,-0.011552126,0.080480866,0.07661252,0.039095405,0.06794545,0.026473716,-0.059279777,-0.008488109,-0.00084658293,0.01081795,-0.019218525,-0.0016793762,-0.0005190817,0.052292783,-0.013664719,-0.03178208,-0.0052378885,-0.025604973,0.049531512,0.08847326,0.0109125115,-0.050378457,-0.023892948,-0.06311101,0.07335185,0.09949079,-4.689757e-08,0.037034713,-0.033441294,0.025928814,-0.061496098,-0.10487387,0.07522755,0.036117982,-0.067508556,-0.016766267,-0.075497314,-0.0133654615,0.008487836,0.003987773,0.098524936,0.045813907,-0.02435548,-0.008736173,-0.0049234503,-0.06118105,-0.017017463,-0.091026984,0.0013603973,-0.07142541,-0.008673301,-0.06152162,-0.06192879,-0.011240281,0.015859036,-0.020960487,0.0015748588,0.027293187,0.001090782,-0.017220674,-0.0043878336,-0.09459312,0.025621623,-0.022232497,-0.032438327,0.028038664,0.055854153,-0.0061920974,0.048254136,-0.04437498,-0.02590629,-0.017873282,-0.017610382,0.012832164,0.064960726,0.0033440355,0.008396843,-0.00313961,0.045975562,0.017068375,-0.073328815,-0.08667007,-0.029051747,-0.06633133,-0.057365123,0.033249907,-0.09796131,-0.025126478,0.017354678,0.14467923,0.031937297 +1.21.3.4,"Also acts on several diphenols and phenylenediamines, but has low affinity for these substrates. Involved in the biosynthesis of mould metabolites related to the antibiotic griseofulvin.",384,1.0,-0.016449045,-0.034747113,-0.05946839,-0.07112054,0.048131905,-0.014881594,-0.007914909,0.06684619,0.050009616,-0.06264991,-0.013466778,-0.004252326,0.024095533,0.045022722,-0.08760546,-0.0018506424,-0.09578312,0.031376127,0.0069262427,0.014047582,0.06519648,0.034231164,-0.0047450955,-0.015950317,-0.0021278684,0.017870829,0.045574885,-0.041044094,0.0048254263,-0.082938105,0.074177414,0.09498127,0.006577195,-0.017728124,0.0003075563,0.06635077,0.014634199,0.041507743,0.117320314,0.06937065,0.009356451,-0.0072576953,-0.046032988,-0.023949679,0.011811311,0.039645653,0.007212044,0.011795567,-0.09630742,0.035260957,-0.017120734,-0.009597324,0.002766618,0.02199536,0.08343236,-0.028053634,-0.040425226,0.017515216,0.017000357,-0.008095017,0.037533484,-0.056070846,0.022517698,-0.0034928608,-0.10596635,-0.040012956,0.023447774,-0.043537103,0.037331235,-0.03657657,-0.016103437,-0.017578227,0.059180632,-0.012367716,0.049972575,0.083909996,-0.011706814,-0.03899127,0.015904792,-0.076117076,0.03687889,0.053169698,0.02155087,0.062061235,0.059346423,-0.030749796,0.09303593,-0.005581938,0.03214787,0.053018343,0.055054948,-0.056934617,-0.02739878,-0.00229434,-0.092419565,0.030711511,-0.020488864,-0.028748851,-0.04435876,-0.0011015247,-0.0741557,-0.007090313,0.0044360184,0.007820111,-0.04249394,-0.046468202,0.01729312,0.03649579,-0.031174889,-0.00086285284,-0.048620738,0.055650543,0.01421646,-0.022800574,-0.11976866,-0.0028688717,0.09334489,-0.034433685,-0.093275405,-0.037458688,-0.04265965,0.038048197,-0.029370097,0.00071868615,-0.036268935,0.042150475,-0.024261044,3.3243564e-33,0.01413288,-0.009570779,-0.01634255,-0.025435796,0.04879365,-0.06959833,-0.089393064,0.03496767,0.06494485,-0.07620548,-0.04760998,-0.07196839,-0.023301614,0.09742176,0.005383638,0.048102725,-0.024152467,-0.019624962,0.037533663,-0.04222476,-0.020318845,-0.009608282,-0.121497065,0.017142374,-0.00044297686,0.047112286,-0.034895983,0.061454765,0.01116616,-0.024624832,0.04698913,-0.09026974,0.023653338,0.076747,0.04391331,0.0322175,-0.013226591,-0.07432703,0.025504634,0.016048793,-0.005067356,0.016272927,0.024087325,-0.049050845,0.035095986,0.0010734976,-0.060650118,0.07378598,-0.0025340393,0.023683468,0.09335369,0.028346352,0.027084827,0.033869643,-0.03633319,0.037230432,-0.05875542,-0.055705454,0.063790955,-0.026740544,-0.015145433,0.030400898,0.012350514,-0.008185471,0.021714723,0.027904728,-0.05344955,0.019632863,-0.029571403,0.022881178,-0.052651744,0.005823184,-0.0035026218,-0.002399998,-0.0059924014,0.030922238,-0.00066200463,-0.087113515,0.040097304,0.028976062,0.026344642,-0.01441983,-0.0382066,-0.091481425,-0.088120125,-0.026438506,-0.025263786,-0.039071586,0.0438935,0.061377484,0.00024141055,-0.112860315,-0.10230861,-0.0033126085,-0.021903915,-4.4364185e-33,0.06687646,-0.08726076,0.07542681,-0.05242473,-0.03735246,0.04014508,-0.02584116,-0.07692965,-0.06123104,-0.022629408,0.0011894675,-0.033136945,-0.0052478565,0.02105135,-0.05944838,0.05947658,0.054825872,0.019522868,0.011755574,-0.038090773,0.0009445716,0.10038457,-0.0006433509,2.5590969e-05,-0.031427227,0.053176377,0.027668305,0.04784491,-0.0015835471,0.09605622,-0.03512068,-0.071106724,-0.03513082,-0.028935313,0.018613638,0.07825173,0.025821574,0.029630419,-0.03964136,-0.129589,-0.03199527,-0.010257084,-0.019093685,0.088403955,0.06834041,0.087644644,0.0018588688,-0.024125502,0.022591218,-0.09576139,0.010050193,0.114407465,0.032914728,-0.0059320894,-0.009819675,-0.044891585,-0.007664334,-0.12790394,0.0834736,-0.0146968225,-0.00873956,-0.08353245,-0.051469624,-0.056194138,0.03424262,0.08785216,-0.010771923,0.11859099,0.09251238,-0.07474842,0.09955572,0.0036085467,0.07929648,0.050887007,-0.088050194,-0.03189008,0.008133645,-0.043072794,-0.015048946,0.031905808,0.029691463,-0.016985096,-0.040593386,0.017041346,-0.057044066,-0.030656355,-0.022145675,0.053722046,0.0072260117,-0.0007611484,-0.04567661,0.09520779,0.0059939795,0.045077562,0.08620618,-3.256795e-08,0.014553666,-0.056477737,0.061521303,-0.042434517,-0.054494843,-0.03962685,-0.030095834,0.017725088,0.015657391,-0.07101176,-0.028909184,0.10345804,-0.063924976,0.047815673,0.13546643,0.0052057267,-0.042258624,0.0015556487,-0.016008768,-0.044452604,-0.083944306,0.01523722,-0.058105707,0.05996578,-0.019790063,-0.062319703,0.09309775,-0.054462004,-0.028922288,0.016942842,0.036207344,0.11652204,-0.02525545,0.013017664,-0.013336017,0.0526122,-0.074492894,0.026069276,0.015952712,0.04434552,0.019916264,-0.011454349,-0.06625659,0.017564522,-0.05478796,0.003674075,-0.030064981,0.0584796,0.0027571847,0.0055124504,0.07939963,0.039683122,0.055156313,0.004888947,-0.18456279,-0.016017986,-0.009370339,-0.05489627,0.005021173,-0.068959974,-0.0689453,-0.031053487,0.16115597,0.017148497 +1.21.3.5,"Also acts on several diphenols and phenylenediamines, but has low affinity for these substrates. Involved in the biosynthesis of mould metabolites related to the antibiotic griseofulvin.",384,1.0,-0.016449045,-0.034747113,-0.05946839,-0.07112054,0.048131905,-0.014881594,-0.007914909,0.06684619,0.050009616,-0.06264991,-0.013466778,-0.004252326,0.024095533,0.045022722,-0.08760546,-0.0018506424,-0.09578312,0.031376127,0.0069262427,0.014047582,0.06519648,0.034231164,-0.0047450955,-0.015950317,-0.0021278684,0.017870829,0.045574885,-0.041044094,0.0048254263,-0.082938105,0.074177414,0.09498127,0.006577195,-0.017728124,0.0003075563,0.06635077,0.014634199,0.041507743,0.117320314,0.06937065,0.009356451,-0.0072576953,-0.046032988,-0.023949679,0.011811311,0.039645653,0.007212044,0.011795567,-0.09630742,0.035260957,-0.017120734,-0.009597324,0.002766618,0.02199536,0.08343236,-0.028053634,-0.040425226,0.017515216,0.017000357,-0.008095017,0.037533484,-0.056070846,0.022517698,-0.0034928608,-0.10596635,-0.040012956,0.023447774,-0.043537103,0.037331235,-0.03657657,-0.016103437,-0.017578227,0.059180632,-0.012367716,0.049972575,0.083909996,-0.011706814,-0.03899127,0.015904792,-0.076117076,0.03687889,0.053169698,0.02155087,0.062061235,0.059346423,-0.030749796,0.09303593,-0.005581938,0.03214787,0.053018343,0.055054948,-0.056934617,-0.02739878,-0.00229434,-0.092419565,0.030711511,-0.020488864,-0.028748851,-0.04435876,-0.0011015247,-0.0741557,-0.007090313,0.0044360184,0.007820111,-0.04249394,-0.046468202,0.01729312,0.03649579,-0.031174889,-0.00086285284,-0.048620738,0.055650543,0.01421646,-0.022800574,-0.11976866,-0.0028688717,0.09334489,-0.034433685,-0.093275405,-0.037458688,-0.04265965,0.038048197,-0.029370097,0.00071868615,-0.036268935,0.042150475,-0.024261044,3.3243564e-33,0.01413288,-0.009570779,-0.01634255,-0.025435796,0.04879365,-0.06959833,-0.089393064,0.03496767,0.06494485,-0.07620548,-0.04760998,-0.07196839,-0.023301614,0.09742176,0.005383638,0.048102725,-0.024152467,-0.019624962,0.037533663,-0.04222476,-0.020318845,-0.009608282,-0.121497065,0.017142374,-0.00044297686,0.047112286,-0.034895983,0.061454765,0.01116616,-0.024624832,0.04698913,-0.09026974,0.023653338,0.076747,0.04391331,0.0322175,-0.013226591,-0.07432703,0.025504634,0.016048793,-0.005067356,0.016272927,0.024087325,-0.049050845,0.035095986,0.0010734976,-0.060650118,0.07378598,-0.0025340393,0.023683468,0.09335369,0.028346352,0.027084827,0.033869643,-0.03633319,0.037230432,-0.05875542,-0.055705454,0.063790955,-0.026740544,-0.015145433,0.030400898,0.012350514,-0.008185471,0.021714723,0.027904728,-0.05344955,0.019632863,-0.029571403,0.022881178,-0.052651744,0.005823184,-0.0035026218,-0.002399998,-0.0059924014,0.030922238,-0.00066200463,-0.087113515,0.040097304,0.028976062,0.026344642,-0.01441983,-0.0382066,-0.091481425,-0.088120125,-0.026438506,-0.025263786,-0.039071586,0.0438935,0.061377484,0.00024141055,-0.112860315,-0.10230861,-0.0033126085,-0.021903915,-4.4364185e-33,0.06687646,-0.08726076,0.07542681,-0.05242473,-0.03735246,0.04014508,-0.02584116,-0.07692965,-0.06123104,-0.022629408,0.0011894675,-0.033136945,-0.0052478565,0.02105135,-0.05944838,0.05947658,0.054825872,0.019522868,0.011755574,-0.038090773,0.0009445716,0.10038457,-0.0006433509,2.5590969e-05,-0.031427227,0.053176377,0.027668305,0.04784491,-0.0015835471,0.09605622,-0.03512068,-0.071106724,-0.03513082,-0.028935313,0.018613638,0.07825173,0.025821574,0.029630419,-0.03964136,-0.129589,-0.03199527,-0.010257084,-0.019093685,0.088403955,0.06834041,0.087644644,0.0018588688,-0.024125502,0.022591218,-0.09576139,0.010050193,0.114407465,0.032914728,-0.0059320894,-0.009819675,-0.044891585,-0.007664334,-0.12790394,0.0834736,-0.0146968225,-0.00873956,-0.08353245,-0.051469624,-0.056194138,0.03424262,0.08785216,-0.010771923,0.11859099,0.09251238,-0.07474842,0.09955572,0.0036085467,0.07929648,0.050887007,-0.088050194,-0.03189008,0.008133645,-0.043072794,-0.015048946,0.031905808,0.029691463,-0.016985096,-0.040593386,0.017041346,-0.057044066,-0.030656355,-0.022145675,0.053722046,0.0072260117,-0.0007611484,-0.04567661,0.09520779,0.0059939795,0.045077562,0.08620618,-3.256795e-08,0.014553666,-0.056477737,0.061521303,-0.042434517,-0.054494843,-0.03962685,-0.030095834,0.017725088,0.015657391,-0.07101176,-0.028909184,0.10345804,-0.063924976,0.047815673,0.13546643,0.0052057267,-0.042258624,0.0015556487,-0.016008768,-0.044452604,-0.083944306,0.01523722,-0.058105707,0.05996578,-0.019790063,-0.062319703,0.09309775,-0.054462004,-0.028922288,0.016942842,0.036207344,0.11652204,-0.02525545,0.013017664,-0.013336017,0.0526122,-0.074492894,0.026069276,0.015952712,0.04434552,0.019916264,-0.011454349,-0.06625659,0.017564522,-0.05478796,0.003674075,-0.030064981,0.0584796,0.0027571847,0.0055124504,0.07939963,0.039683122,0.055156313,0.004888947,-0.18456279,-0.016017986,-0.009370339,-0.05489627,0.005021173,-0.068959974,-0.0689453,-0.031053487,0.16115597,0.017148497 +1.21.3.6,"A copper-containing glycoprotein that plays a key role in the yellow coloration of flowers such as Antirrhinum majus (snapdragon). The enzyme is a homologue of plant polyphenol oxidase [1] and catalyses two separate chemical transformations, i.e. 3-hydroxylation and oxidative cyclization (2',-dehydrogenation). H2O2 activates reaction (1) but inhibits reaction (2). Originally considered to act on the phenol but now thought to act mainly on the 4'-O-beta-D-glucoside in vivo [4].",384,1.0,-0.08193189,-0.043916136,-0.014477623,0.05858563,0.11722992,0.04828066,-0.001036508,0.0012452689,0.069203824,-0.044146698,0.063499525,0.03842424,-0.046479985,-0.053033024,-0.07573032,0.074811906,-0.020128382,0.057789866,-0.07470432,-0.060127966,0.04620735,-0.040562067,-0.0023282918,0.015133088,-0.039190948,-0.0039687543,0.00061168714,-0.017267669,-0.03511598,-0.04457537,0.037828237,0.057608988,0.04273465,-0.0014246593,-0.037597325,0.0030439247,0.001224795,-0.08372455,0.009072544,-0.024266236,0.0445927,-0.033054344,-0.027522797,-0.01940676,-0.028375896,-0.053366274,0.050894417,0.035226163,0.032567915,0.0025731833,-0.06624486,-0.07233876,-0.07025111,0.015567279,0.023019012,0.10222578,-0.014555006,0.02528564,0.038578566,0.0047417027,0.055246513,0.013650391,0.04546763,0.089388445,-0.06442872,-0.047951605,-0.040571403,-0.024420712,0.034185212,-0.051112168,-0.0066374284,-0.021529531,0.02633311,-0.030344857,0.025952753,0.047763065,-0.0013731645,-0.034150302,0.015662236,-0.047711655,0.032803256,0.02758687,0.0563268,0.079676636,0.0935182,0.059488077,0.004722579,-0.0044906633,-0.03772415,-0.02195511,0.07019317,-0.02613741,-0.022243926,0.028012406,-0.07135827,0.04930397,0.0964858,-0.11639123,-0.08595121,-0.030369902,0.015892038,0.030259568,0.033488024,-0.10298555,-0.020845514,0.03075589,-0.07710959,-0.005134546,0.023419369,0.020114586,0.0003009444,0.0030404693,-0.041581187,0.006920174,-0.059018046,0.03414088,0.01113272,-0.048173696,-0.08501746,-0.045220934,0.03595211,-0.06373905,-0.012565073,0.048826337,-0.054013975,0.00037040075,-0.05795223,1.9408516e-33,0.04610823,0.006821718,0.02449549,0.0035600178,0.020577108,-0.06285944,-0.03967717,-0.05014631,-0.01741724,-0.03854731,-0.111355595,-0.06326061,-0.026085038,0.09485695,0.031493843,-0.020000419,-0.07339867,-0.043217078,0.08441145,0.041127495,0.0038416376,0.018771034,-0.069835976,-0.012404949,0.014904575,0.07073231,-0.035507105,-0.009146951,0.0801271,0.015489428,0.050906416,-0.06497689,0.027035952,0.07417005,-0.017310021,-0.04199817,-0.04137563,-0.097743765,0.017000826,0.09214202,-0.039891083,-0.005222949,0.017105233,-0.022930717,0.044938713,-0.074449256,-0.032011416,0.09895083,0.022001995,0.09265851,0.014908868,-0.025109326,0.10899002,0.020785958,-0.06647183,-0.02708184,-0.038570974,-0.020235606,0.03639984,0.024591345,-0.06379095,0.023580698,0.006930087,-0.015152746,-0.02334914,0.036225587,-0.12146545,-0.03218345,-0.024789244,0.05432283,-0.00068614754,-0.0017750909,0.011707298,0.015085314,0.053377338,-0.06601594,0.031905033,0.037508167,0.09836347,0.05383788,0.013296088,0.022676319,0.008382192,-0.0029684547,-0.0633693,-0.01379837,-0.03526201,-0.0051424457,-0.046074558,0.03120933,0.050297488,0.016024664,-0.04204134,0.016551036,-0.04644504,-4.154952e-33,0.07237342,-0.05883464,0.050754424,-0.018945608,-0.015719464,0.023845822,-0.06524218,-0.031789355,0.02025075,-0.035905853,0.053894654,0.06557301,0.0006822719,-0.0423275,0.036447756,-0.019778747,0.020952675,0.13328505,-0.069439255,0.004380962,-0.055079047,0.0123766055,0.011559471,-0.0427948,0.010157424,0.0064480696,-0.001449369,-0.065109424,0.025595132,0.07423313,0.025491195,0.03311394,-0.08509563,0.01795383,0.023195233,0.014376108,-0.058271337,-0.03162998,0.012920837,0.09268872,0.01663062,-0.021528376,0.06681829,0.07768878,0.07673168,0.051962346,-0.09291762,0.06520686,-0.072260596,-0.033623017,0.0163659,0.073257536,0.001851087,0.091598615,0.10100926,0.03064678,-0.011629413,-0.0606285,-0.036372516,-0.01546109,-0.04427783,-0.055146154,-0.03699199,0.022506021,-0.00078750117,0.055880222,-0.034110326,0.123773955,-0.019448305,-0.033573847,0.08562664,-0.002014936,-0.03238326,-0.020945242,-0.034707554,-0.070082024,-0.05201415,-0.014871827,-0.009008818,0.034493502,-0.053996254,0.04180503,0.001795592,-0.10770917,-0.017572328,-0.102929205,-0.055096246,0.1599956,0.069660485,-0.038631234,-0.037605252,-0.004464276,-0.0468079,0.050173424,0.14463079,-4.686024e-08,-0.047608916,-0.08586921,0.09966149,-0.12956831,-0.010261241,-0.002540683,0.016937511,0.013927796,0.028715564,0.018909108,0.013147683,0.09688509,-0.024810914,-0.06273276,-0.03261475,0.078971155,0.017505938,0.007882228,0.010559626,0.030334348,-0.069433905,-0.0031735494,-0.12820116,-0.009920341,-0.036992285,-0.063663855,0.056792237,0.016447205,-0.09658524,0.005004613,0.035733517,0.05170492,-0.03601249,0.0053693983,-0.06589557,-0.005075946,0.056123175,0.010774084,-0.030580066,-0.016139725,-0.06897432,0.0014437883,-0.006907577,0.0036940046,0.03316756,-0.020873686,0.043102115,-0.0014676248,0.015947282,0.015286934,-0.024512023,0.008781389,-0.014244544,-0.08346086,-0.13703097,0.0161678,0.03493781,-0.006180099,-0.01126679,-0.07208724,-0.017263338,0.0015353799,0.13892394,0.05773344 +1.21.4.1,"A pyruvoyl- and L-selenocysteine-containing enzyme found in a number of Clostridial species. The pyruvoyl group, located on the PrdA subunit, binds the substrate, while the selenocysteine residue, located on the PrdB subunit, attacks the alpha-C-atom of D-proline, leading to a reductive cleavage of the C-N-bond of the pyrrolidine ring and formation of a selenoether. The selenoether is cleaved by a cysteine residue of PrdB, resulting in a mixed selenide-sulfide bridge, which is restored to its reduced state by another selenocysteine protein, PrdC. 5-aminopentanoate is released from PrdA by hydrolysis, regenerating the pyruvoyl moiety. The resulting mixed selenide-sulfide bridge in PrdC is reduced by NADH.",384,1.0,-0.032738637,-0.073878676,-0.061730087,-0.041702256,0.040141854,-0.0063210656,-0.020997846,0.058846813,0.07899076,-0.04313873,0.048701834,0.04266196,0.0037992324,0.009174529,-0.035870858,0.088155404,-0.039802685,0.046494607,-0.031159904,0.024725318,-0.011994418,-0.012314815,-0.00866052,0.030010257,-0.0032508543,-0.027583204,0.07931085,0.050643515,-0.077656254,-0.043413334,-0.023089018,-0.10482345,0.004603698,-0.047527872,0.091684535,0.059081186,-0.08952566,0.024573594,0.009171664,-0.038930632,0.006827772,-0.028436625,-0.088758156,-0.027029466,-0.10629459,-0.01894744,0.020464707,0.04443838,-0.017407913,0.01917216,-0.0032015413,0.0019096622,-0.111673914,0.06964167,-0.0095313415,0.057976685,-0.018488493,0.024984412,-0.024647236,-0.016796026,-0.003451267,-0.013697159,-0.0012073789,-0.035075996,0.010285348,-0.07284643,0.077597335,-0.0055653206,0.016302468,-0.047389645,-0.039651062,-0.020159261,0.04283161,0.02412875,0.05175391,0.04017391,-0.038293615,-0.06720717,0.02000994,0.015067622,-0.030092476,0.0042851483,0.03211821,0.08971102,0.076551564,-0.0019513641,0.046666935,-0.030265983,-0.0046891253,0.02279023,0.064928815,0.033639524,0.000791367,-0.022482187,0.01010872,0.07051873,-0.013265733,0.03443493,-0.043348547,-0.011266754,-0.017730366,0.056891147,-0.039226152,-0.0886081,-0.03548858,0.028824909,-0.024095116,0.055728626,0.006116978,-0.062028147,0.015194517,0.009185923,0.022887522,0.026704485,0.0030466402,0.06831247,0.052803416,0.030460157,-0.002252846,-0.0039947443,0.018662814,0.045420017,0.0135332905,0.068680495,-0.02125452,0.06585691,-0.057037834,4.366568e-33,0.062063348,0.034859493,0.07441682,0.0070528453,-0.028790636,-0.006899486,-0.12390497,0.07223113,-0.03244529,-0.056074493,-0.08065407,-0.15559769,0.097502336,-0.04484815,-0.029656047,-0.10054493,-0.030004729,0.042750612,0.041197322,-0.042111773,0.0050061354,0.06392667,0.058797237,0.02117219,0.025807522,0.020876132,-0.0017621048,0.055159394,0.03635236,0.014452771,0.0029289816,-0.065306924,-0.1211429,-0.025742786,0.094740905,0.04008508,-0.011675398,-0.02829829,-0.08091699,0.060298797,-0.075475276,0.02037586,-0.019827727,-0.050580423,0.016334606,-0.13380896,-0.008729562,0.14264748,0.0056511424,0.037032183,0.0049011977,-0.046875432,0.1007558,-0.015034149,-0.0797982,-0.04376957,-0.035393752,-0.04368219,0.07293767,0.051349994,0.07584679,0.06763962,-0.051458195,-0.045071974,0.049101822,0.02730534,-0.08348348,-0.03707522,-0.0056333616,-0.018813936,-0.058101278,0.01494506,-0.026917323,0.03298183,0.011890956,-0.034440316,-0.10579996,0.033174686,0.061221253,0.006020516,-0.047670335,-0.036051553,-0.034043636,-0.0018747661,-0.06689139,-0.09745294,-0.038135722,-0.05431596,-0.028067263,0.0009724045,0.026398309,-0.114747226,-0.03271251,0.008345825,-0.024260974,-5.054714e-33,0.04733267,-0.099394746,0.028371477,-0.010293878,-0.0116604315,-0.00896346,-0.0028482676,-0.00424071,-0.028423013,-0.067425564,0.016226493,0.0065868082,-0.021037381,-0.016279928,0.03364208,0.030474614,-0.024671841,0.051453568,0.040248115,0.0034570824,0.005477112,0.043117296,-0.010075511,0.10357888,0.019507222,0.025960699,0.057930704,0.0044305753,0.08239469,0.077818595,-0.007849641,0.005167814,-0.02212402,0.04996228,-0.068454474,0.12795562,-0.058797255,-0.0028670044,0.06629916,0.024851985,0.043779306,0.021596774,-0.005675177,0.03648663,0.082879424,0.026704593,-0.067515306,0.124501765,-0.0018542657,-0.039948467,0.046129208,0.019773379,0.025221102,-0.026805842,0.041366544,0.033438995,-0.010980594,-0.020329166,-0.042198006,-0.030048512,-0.072951466,-0.05619307,-0.04964467,0.05764146,0.015452929,0.0018126031,-0.0014544193,0.019337816,0.008150499,-0.07274722,0.040062718,0.010469508,-0.034186043,-0.06972965,-0.05879819,-0.06786026,-0.0075445767,0.061492383,0.009475056,0.07326015,0.005081986,-0.044821523,0.06149683,-0.10569649,0.02976148,-0.023101436,0.011426802,0.053430498,0.022728946,-0.004820012,-0.03988353,-0.005932938,-0.006509604,0.14745465,0.12909907,-4.7972375e-08,0.12540607,0.002969949,0.073049255,0.005161743,0.07458058,-0.044382516,0.061149355,-0.00014295203,-0.031669285,-0.026220962,-0.02036201,0.09702897,-0.016257936,-0.041062336,0.06855064,0.0629579,-0.0349176,0.023608346,-0.02938307,-0.010495414,-0.071332365,-0.0458244,-0.14764701,0.039981835,0.03136113,-0.077336244,0.019186182,-0.04986217,-0.010737547,-0.03558437,0.09159334,-0.03323297,0.009122974,-0.083420336,-0.050322726,0.023672596,-0.029641945,-0.011879136,0.05137785,0.038082317,-0.03689417,-0.016553998,-0.023055717,-0.022382887,0.048518557,0.0021186294,-0.037967376,0.017259374,-0.09136102,0.049192164,0.039836578,-0.004031317,-0.03132254,-0.010002552,-0.07620059,0.087594956,0.0047810487,-0.05207451,-0.012242599,-0.06308142,-0.0045199376,0.058590043,0.11393353,-0.019449117 +1.21.4.2,"The reaction is observed only in the direction of glycine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for glycine binding and ammonia release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.3 (sarcosine reductase) and EC 1.21.4.4 (betaine reductase).",384,1.0,-0.008900244,-0.023963211,-0.09016605,-0.05196476,-0.02274,0.062259685,-0.030836428,0.04738272,0.03850334,-0.007291728,0.03892354,0.033638198,0.020752955,-0.028816033,-0.04822116,-0.02773921,-0.001569289,-0.0026358224,-0.04494383,-0.074564256,0.017031798,-0.005407285,-0.057642758,-0.037479702,0.03619277,-0.0072151353,0.06364889,-0.05054298,-0.09985118,-0.094233595,-0.030527733,-0.12191999,0.05037094,-0.060251318,0.059860576,0.048302487,-0.07776969,-0.066207245,0.067238875,0.006564167,0.027012782,0.019469047,-0.0531797,-0.050845105,-0.059407637,0.06401316,0.0105369985,0.012256731,0.025275014,-0.026925312,-0.036180988,0.0147007555,-0.06853538,0.010989865,-0.0066202506,0.016545879,-0.12479559,-0.0010413973,0.023616413,-0.024909709,0.032801267,0.0061729355,0.034167018,-0.05172049,0.053064376,-0.050040506,0.09215679,-0.11779957,-0.012153252,-0.021028772,-0.036768775,-0.050228726,0.019792333,0.023471087,0.00090713287,-0.028741647,-0.020425327,0.0023537276,0.050865736,-0.00065090595,0.0081410585,-0.029910155,-0.017289924,0.05977753,-0.05483537,0.009322166,-0.018459642,0.004915446,0.030582061,0.050410096,0.09426005,-0.06707302,0.034084357,-0.0120193325,-0.0075874357,-0.024135495,0.008295333,0.0452096,0.0053664725,-0.044754267,-0.023200992,0.09842417,-0.016852932,-0.07226199,-0.056686148,0.0061051375,0.032835662,0.10645699,0.048030972,0.01424215,-0.015703479,-0.009195238,0.0031737767,-0.03766266,-0.007503626,0.07835013,0.08157884,-0.035909694,-0.11919331,-0.003552971,0.08840362,-0.039947048,0.10449357,0.08268862,0.007833383,0.06099895,-0.12620892,5.481604e-33,0.05202218,0.029573273,0.051472023,-0.051362477,0.064967945,0.047843367,-0.119420186,0.034811847,0.003846125,-0.08150815,-0.12647633,-0.0574234,0.026539082,-0.033916987,-0.025479551,0.016895367,-0.04007886,0.016038807,0.04396982,0.010423078,0.039969284,0.01989763,-0.0023270638,0.06734281,0.016101232,0.020615887,-0.06590233,0.017748944,0.021317776,0.014750079,0.01660374,-0.09088211,-0.14109051,-0.012978096,0.06816897,-0.015171177,-0.057234164,-0.0035732456,0.019022048,0.0638892,0.013263648,0.030969596,0.008460334,0.023893373,0.046370417,-0.027531182,-0.015263347,0.08317903,0.060325757,0.033088863,0.012657751,-0.06662927,0.13701586,-0.06087718,-0.01843688,0.035215355,-0.01299669,0.030803358,0.019048825,0.10761805,0.04993859,0.07629086,-0.027998237,-0.02473647,-0.0135469735,0.022878923,-0.083123855,-0.022039872,0.0076601687,-0.02931133,-0.025111202,-0.03421653,0.09452925,0.06893864,-0.036501177,-0.053492863,-0.06486206,-0.00748088,-0.002904488,-0.05850206,-0.027907128,0.036620762,-0.008038377,-0.029658936,0.031758934,-0.004424802,-0.010197236,-0.0578527,0.062676184,0.006124285,0.041121148,-0.049619894,-0.10217347,-0.006745913,-0.026946928,-5.925907e-33,0.108019665,-0.09788586,0.0237819,-0.007220729,0.008258293,-0.0107870875,0.062005956,0.027302807,0.023375615,0.007195063,0.077289835,-0.03495301,-0.013913599,0.017836772,1.2891411e-05,0.015090436,0.023838673,0.074673556,-0.04355042,-0.03327347,-0.039645173,0.023998924,0.0011421255,0.0054331683,0.000653741,0.026501514,-0.020815426,0.069855444,0.047308184,0.01490919,-0.033802204,0.034978896,-0.05948953,-0.07549222,-0.09174291,0.08767455,-0.066735305,0.0010275015,0.012845431,-0.033211883,0.041169338,0.023650117,0.0030053514,0.038291004,0.07804128,0.070936315,-0.0010319452,0.02967121,-0.030210325,-0.047694955,0.055286743,-0.03590846,0.04347933,0.05451335,0.013865863,0.06651711,0.027579328,0.045772925,-0.0419954,0.020361848,-0.0045315563,-0.08317531,0.064225614,-0.0022278696,0.06261239,0.011831378,0.023368612,0.12474573,0.072756335,-0.031579487,-0.025333835,-0.041794427,0.08272009,0.022166075,0.047562838,-0.010435278,-0.09260423,-0.0026745533,0.018883793,-0.033354074,-0.036640253,-0.010698962,-0.050133273,-0.06043434,0.019727442,-0.017496495,0.042535644,0.14641967,-0.058646277,0.056276236,-0.040140733,-0.03246108,0.014387655,0.12946245,0.050909523,-4.6709744e-08,0.07619995,-0.030833732,0.05228395,-0.052507296,0.100026086,0.06439719,-0.033785146,0.049507998,0.03274324,-0.089406714,-0.070648335,0.042010024,-0.032322556,0.0008476725,-0.004123697,0.08593541,-0.09145439,0.0062387227,0.005009577,0.00497104,-0.06254448,-0.016490055,-0.10790922,0.06805218,0.025816403,-0.035923425,0.027433164,0.024862025,-0.08382728,-0.038116574,-0.030551715,0.012696339,-0.014765135,-0.0647563,-0.08590958,-0.029447075,-0.021439685,0.030491754,0.009357807,0.035279863,-0.015389908,-0.01684399,-0.08993812,0.03256382,0.06727815,0.038217973,-0.01807224,0.012654897,-0.08579754,-0.019929646,0.002601796,-0.034376282,0.009251387,-0.04436487,-0.09496787,0.009148072,-0.027031453,-0.0719498,0.0024530813,0.019504938,-0.030202543,0.04920236,0.121154726,-0.005582592 +1.21.4.3,"The reaction is observed only in the direction of sarcosine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.4 (betaine reductase).",384,0.99999994,-0.008060245,-0.032196864,-0.1129263,-0.03018001,-0.017497387,0.06286394,-0.027451102,0.062548496,0.046801627,-0.0057717096,0.03155886,0.019258246,0.030198362,-0.02793781,-0.022587206,-0.018169764,-0.03030582,-0.002980505,-0.01744307,-0.06428911,0.036113217,-0.00029369758,-0.04319661,-0.041708097,0.01842448,0.013449885,0.058196764,-0.05227827,-0.120136954,-0.07649232,-0.017509285,-0.09736489,0.054339,-0.051248427,0.07880194,0.03599517,-0.064960174,-0.06883949,0.057850346,0.005973966,0.021394765,0.02889452,-0.043037202,-0.04928677,-0.06434828,0.04843161,0.003386057,0.01888052,0.026857832,-0.026229862,-0.045039665,0.017467594,-0.063033596,0.037861947,-0.009915385,0.03036128,-0.121792756,-0.011870629,0.028625615,-0.014628697,0.04530595,0.011463593,0.020278862,-0.047320377,0.04812879,-0.047328003,0.09395661,-0.115505785,0.003444154,-0.01110629,-0.048820723,-0.039342996,0.030543812,0.03937016,0.008790194,-0.04620488,0.0043552215,-0.008058904,0.047485594,-0.009743537,-0.012023757,-0.03051809,-0.017477743,0.07705457,-0.058273662,-0.0020517139,0.010426319,0.0029280013,0.05931588,0.0579598,0.11281228,-0.052299313,0.0095642125,-0.0112495655,-0.021317717,-0.025323994,0.012369165,0.05676301,0.013555811,-0.040161546,-0.006742559,0.06937244,-0.024937132,-0.08541135,-0.040377073,0.004176026,0.03727004,0.105940774,0.04226321,0.0019797515,-0.005190925,-0.013373672,-0.011589803,-0.03923366,-0.0011908027,0.07605999,0.07170353,-0.065860085,-0.13720663,-0.005618288,0.07772291,-0.06395135,0.08628434,0.066284485,0.019092448,0.03835537,-0.1444848,5.639141e-33,0.05603219,0.04664858,0.058734145,-0.07117499,0.063200414,0.042879045,-0.1075885,0.02738704,-0.012080136,-0.07090961,-0.1422884,-0.07144329,0.01747733,0.0026513687,-0.013935704,0.018230746,-0.048992686,0.01770128,0.05076333,0.009222765,0.043277252,0.04085615,0.0070711854,0.05670781,0.00795941,0.043633778,-0.07667635,0.028984534,0.029368063,0.017114894,0.024446193,-0.08107263,-0.12317228,-0.008857548,0.07164672,0.007257005,-0.060615618,0.024523173,-0.0048805582,0.07811634,0.0292866,0.040971845,0.0002998759,0.0299792,0.03571552,-0.072924346,-0.024722021,0.07863512,0.07477029,0.057689153,0.007302356,-0.0570377,0.14982371,-0.075227685,-0.014207621,0.028618585,-0.022731338,0.018573819,0.027398195,0.08291161,0.05813287,0.02993849,-0.03256966,-0.021071466,-0.011600647,0.028093811,-0.059960056,-0.02425088,0.0009894067,-0.046682082,-0.037420712,-0.036838602,0.08928901,0.06655978,-0.0151759535,-0.035919644,-0.09470445,0.0031321696,0.0008495433,-0.043234676,-0.03499796,0.01622679,0.0023625037,-0.023956254,0.011404687,0.0135952905,-0.014361296,-0.04070239,0.06608249,0.013261906,0.03233594,-0.054423742,-0.08417359,-0.00067816704,-0.02127645,-6.498868e-33,0.10868017,-0.089994594,0.024047518,-0.026192907,0.0090606995,0.0018449026,0.07598487,0.034677938,0.010401457,0.0124229705,0.084100455,-0.031847272,-0.024602722,0.0065303766,-0.0054331287,0.0140693365,0.032679234,0.10342166,-0.038670894,-0.016735232,-0.028890897,0.032296803,-0.003098103,0.01903627,-0.011330645,0.02464487,-0.0028593796,0.055330534,0.03477673,0.010408685,-0.037923817,0.029407501,-0.06338779,-0.076298706,-0.08629266,0.101002306,-0.08518095,-0.010802492,0.017384788,-0.0019141461,0.031847678,0.02412722,0.016888356,0.039829124,0.08365763,0.044573378,0.004087098,0.037842844,-0.040012717,-0.05937778,0.050157495,-0.045290098,0.048519004,0.023790384,0.028149966,0.060130436,0.0028602518,0.042404056,-0.04923219,0.0069756266,-0.035567302,-0.08469508,0.054908074,-0.018484782,0.07782209,0.01696436,0.0031548485,0.12310254,0.06126049,-0.049487825,-0.01642787,-0.03497636,0.06252643,0.014413473,0.021761775,-0.040477112,-0.112636626,-0.008562346,0.005884087,-0.014592363,-0.020464465,-0.015812377,-0.043610543,-0.096434206,-0.007648416,0.009800632,0.042279948,0.10754464,-0.06264987,0.049209256,-0.0505517,-0.040931102,0.010905805,0.12253578,0.053131696,-4.8395243e-08,0.072379835,-0.02317999,0.033797197,-0.039727546,0.09524616,0.061083898,-0.031924248,0.059802484,0.045849558,-0.08076752,-0.040529337,0.05672483,-0.013721649,0.0193874,-0.023133023,0.06562269,-0.09435918,-0.011306669,0.0026782746,-0.011937919,-0.059773065,-0.027718244,-0.089096114,0.069607325,0.047339033,-0.03611665,0.028909605,0.028796803,-0.080965005,-0.030765777,-0.04502024,0.0053437874,-0.041145343,-0.057764094,-0.068456806,-0.036544174,-0.020203754,0.009997316,0.010186601,0.050345127,0.0044560903,-0.0067333854,-0.10688072,0.042291176,0.07508487,0.04295846,-0.028833626,0.016788583,-0.0886145,-0.03849792,0.013595723,-0.04538079,-0.017564986,-0.06178605,-0.09159944,0.017833155,-0.025785739,-0.062104296,-0.0020191446,0.027549583,-0.026870083,0.04776412,0.12700857,-0.017548252 +1.21.4.4,"The reaction is observed only in the direction of betaine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for betaine binding and trimethylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.3 (sarcosine reductase).",384,1.0,-0.016041325,-0.03138485,-0.082867466,-0.013607877,-0.01586021,0.069877185,-0.032568313,0.047094066,0.033278115,-0.01422365,0.040171787,0.01049668,0.015499575,-0.032435026,-0.029220037,-0.013148039,-0.014337972,0.0034427221,-0.015673665,-0.066177286,0.012765729,-0.0029495559,-0.05731745,-0.020464474,0.04486153,0.0023944152,0.06658986,-0.054452065,-0.107294105,-0.09286263,-0.00705955,-0.120635554,0.082363196,-0.037486956,0.060140625,0.03692298,-0.08359724,-0.095215514,0.06170122,0.0131011745,0.026544191,0.020132737,-0.06010275,-0.040549815,-0.046176568,0.059052736,-0.0012431503,0.028072719,0.035152603,-0.036710676,-0.04130755,-0.0008553884,-0.061429583,0.023323474,-0.015154987,0.019474585,-0.08292785,-0.006585401,0.04720485,0.0032966337,0.041633684,0.013362082,0.028768256,-0.045536052,0.04938995,-0.041655295,0.08164699,-0.11375691,0.0026796395,-0.023877278,-0.04634648,-0.030189505,0.016579816,0.033644512,0.006395736,-0.056971475,-0.0018649689,-0.0074918084,0.028946992,0.00853803,-0.011707603,-0.049466122,-0.02883505,0.06505341,-0.048901983,0.00013690021,-0.013804469,0.008423712,0.028844453,0.06412734,0.10637368,-0.046276532,0.016680637,-0.0024136265,-0.023566425,-0.02094166,0.010606963,0.035442542,0.022553097,-0.0324381,-0.025675613,0.076978125,-0.017682277,-0.076424375,-0.047975574,0.017440138,0.04969103,0.099283256,0.048935547,0.01240842,-0.0052831587,-0.04010119,0.017188523,-0.012148728,-0.008925938,0.05853897,0.07251637,-0.052930404,-0.10653711,-0.0005815921,0.09147836,-0.06715577,0.08223896,0.065715425,0.0010843218,0.055528402,-0.15268801,5.8716413e-33,0.051117774,0.05281787,0.040740136,-0.044544693,0.054878492,0.050459918,-0.12889652,0.021292651,-0.008062514,-0.09285642,-0.1207444,-0.06894859,0.029098717,-0.008677119,0.003249475,0.009497035,-0.04186692,0.038328487,0.06960264,0.016371073,0.024364738,0.011207508,-0.0059924084,0.04918921,0.032469105,0.029050058,-0.078059174,0.033355143,0.030058548,0.019380344,0.015126317,-0.07976711,-0.10713554,-0.0010841672,0.0749138,0.008945101,-0.043461297,0.0057339524,-0.023644336,0.054591447,0.019664826,0.046473593,-0.0106155295,0.03018124,0.044383876,-0.07299263,-0.024759943,0.08133144,0.075157255,0.044817217,0.0025809268,-0.055733632,0.15618286,-0.07968947,-0.0013219625,0.040859815,-0.03550291,0.01717187,0.036202278,0.07970934,0.0533494,0.06126453,-0.031686638,-0.032409362,-0.006230341,0.029781235,-0.0701248,-0.020359857,-0.0027954995,-0.06674606,-0.045730747,-0.017943352,0.07945391,0.0633491,-0.023037562,-0.042509,-0.08723453,-0.015223701,0.014613042,-0.072158515,-0.032053337,0.017568503,0.009129302,-0.044161435,0.05404886,0.0018750853,-0.001686413,-0.03049833,0.06602146,0.0006661063,0.033874523,-0.07289077,-0.100234345,0.015338624,-0.0055443347,-6.167569e-33,0.10725501,-0.09886021,0.017802985,-0.021344665,0.023687018,-0.006151302,0.06003609,0.01761963,0.01575336,0.01296914,0.07748184,-0.037454836,-0.028026085,-0.008456786,0.009121,0.00093584077,0.03724919,0.07717478,-0.048750326,-0.03556383,-0.024907487,0.021666436,0.011388345,0.009430614,-0.021608595,0.0287681,-0.012422999,0.06051869,0.058124337,0.022830695,-0.046113588,0.0369506,-0.05202071,-0.08536048,-0.08933741,0.09305145,-0.08280937,0.012094862,0.046746213,-0.0026479992,0.05004573,0.02606224,-0.0051092533,0.020387957,0.083509825,0.07849622,0.02385703,0.03998903,-0.03622151,-0.06835442,0.052530415,-0.04425412,0.038645677,0.055485036,0.019616015,0.048371535,0.009459152,0.071498066,-0.036657397,-0.018895978,-0.017825965,-0.0835297,0.067512415,-0.0018302379,0.05841558,0.009336552,0.015071528,0.14623518,0.057668217,-0.05717377,-0.031527985,-0.032235455,0.06526223,0.023444183,0.033527758,-0.040399432,-0.11199818,-0.016779711,0.01656367,-0.013507892,-0.03543605,-0.008717598,-0.05167276,-0.080554664,-0.00059427146,-0.0026299073,0.02717344,0.12194623,-0.066719614,0.03661441,-0.0531299,-0.029141888,0.0090515455,0.12337735,0.0649382,-4.6936826e-08,0.07708394,-0.00070645567,0.0461396,-0.05541602,0.09497218,0.040663656,-0.01759451,0.057805166,0.04181117,-0.0832531,-0.05387922,0.05790807,-0.019725302,0.0072123455,-0.007690809,0.05413761,-0.0873031,-0.010058357,0.0051233633,0.005912507,-0.043893114,-0.020664064,-0.072411,0.075582325,0.02787691,-0.057590872,0.026164154,0.02603847,-0.090811625,-0.04146379,-0.039186765,0.025929531,-0.034858175,-0.07586504,-0.070562616,-0.026940156,-0.012948258,0.013360325,0.030113153,0.05018402,-0.0071431366,-0.038301174,-0.103579275,0.02833037,0.06354446,0.041502584,0.010999215,0.027511097,-0.080518484,-0.048090674,0.017572029,-0.052146263,-0.025715956,-0.044175375,-0.08890436,0.02312959,-0.021312771,-0.061669998,-0.0070895376,0.013000631,0.00044478886,0.032758154,0.13107866,-0.01768114 +1.21.99.1,A flavoprotein (FAD). Cytochrome c and various dyes can act as acceptor. Cyclopiazonate is a microbial toxin.,384,0.99999994,-0.087575175,-0.04642081,-0.09641745,-0.0048991833,0.0694732,0.004812417,0.049701355,0.08601391,0.026926737,-0.021591809,0.008058488,0.015740996,0.0057436,0.032342087,-0.10347172,0.07890139,-0.06843634,-0.025316918,-0.059045468,0.036518943,-0.039036978,0.03633598,0.03098955,-0.01900391,-0.039803702,-0.010377187,-0.028841088,-0.017451258,-0.042006098,0.007920826,0.022479676,0.10901467,0.05505498,-0.020485753,0.0015250325,0.011869781,0.01604603,-0.0069362395,0.0043099388,0.0041091386,-0.017385501,0.028023627,0.046404686,0.012456645,0.04622497,0.02681911,-0.0015300125,0.037606858,-0.007727849,-0.007679596,-0.011584297,-0.019773437,-0.110037744,0.034976203,0.0027799115,0.06544811,-0.03541193,-0.06426227,-0.010647715,0.02079563,-0.029795468,-0.026237031,0.011201481,0.04835961,0.07572045,-0.020190945,-0.06278651,-0.05599755,0.052574698,-0.048931517,0.017613908,-0.085120164,-0.05453311,0.02981651,0.049486905,0.08813653,-0.025947781,-0.015557655,-0.009543469,-0.017274443,0.051420324,-0.0016410188,0.10789091,0.0594363,0.10269487,-0.023323474,-0.03164789,0.0136349,-0.075601935,0.113602564,0.018709442,0.06499184,0.028135981,-0.022545394,-0.058624666,0.023600742,0.11005067,-0.08587644,-0.0049408297,-0.011702495,-0.009051991,-0.018007588,-0.005572336,-0.015685221,-0.040712453,-0.07623197,0.019928467,0.03785412,-0.051097523,-0.050147608,-0.041132778,-0.03559035,0.01890358,-0.08626503,-0.0044934275,0.050172333,0.03749958,-0.044915617,0.03694434,-0.007846497,-0.062289365,0.0667486,-0.012828782,0.05041677,0.052204456,0.009411004,-0.10375581,9.897466e-34,0.03785816,0.008502946,-0.001487591,-0.006609261,-0.0015166062,0.02818909,-0.056591284,-0.04410762,0.029416699,-0.05792225,-0.008912355,-0.0023083189,0.001502443,0.003936708,0.04585949,0.06883982,-0.046052575,-0.05894593,0.049913075,-0.122418165,0.050412387,0.033138778,0.000100776175,-0.030268736,-0.003371401,0.010394654,-0.08347304,0.05733471,0.031458735,0.021738138,-0.02210014,-0.0615026,-0.059369884,-0.009586428,-0.039127845,0.058956206,-0.07057509,-0.08722233,-0.1251266,0.039495867,-0.06895969,-0.045873716,-0.07320748,0.05609332,0.038915537,-0.028952746,-0.13506925,0.028386999,-0.04521867,0.06785211,0.049885504,-0.05626544,0.084178485,0.051591657,-0.10061693,0.009709437,-0.017987054,-0.03463365,-0.037991166,-0.02031474,0.02586277,0.08432555,-0.019917572,0.0875329,-0.02520698,-0.005012366,-0.02733709,-0.062342692,-0.027926102,0.0775067,0.014341978,-0.02882986,0.07120167,0.034966756,0.063613065,-0.037989676,-0.015279626,-0.036417533,-0.0032507933,0.023489906,-0.004369034,-0.09882997,-0.026204914,-0.027422678,-0.062929995,0.018415906,0.0023248645,-0.033866465,0.0065947156,0.019994508,0.035716247,-0.078832895,-0.0012505355,0.027396256,0.0023358227,-1.5180022e-33,0.036817074,-0.06748455,0.05301048,0.03456544,0.022292329,0.0038206412,-0.02138099,-0.03324333,0.062654704,-0.059822004,0.01410189,-0.049348056,-0.007923751,0.04779109,-0.008211629,-0.002001328,-0.027522666,0.059309542,0.029066086,0.049545154,-0.08915425,-0.05750165,0.034773618,0.059628967,0.011701633,0.03393277,-0.014291676,-0.053693485,0.038813207,0.033572778,-0.051658582,0.084264085,-0.029951543,-0.04412051,-0.015021485,0.025656208,-0.02989553,-0.012457814,-0.037469655,0.03782066,-0.017631507,0.015947679,-0.0050684917,0.07710108,0.06762264,0.070185594,-0.022974044,0.026892198,0.0588528,-0.031226283,0.044154663,0.059622273,0.019710429,0.07704497,0.09607657,0.0695503,0.095613874,0.031064764,0.00020905862,0.037313007,0.04839765,-0.089632414,-0.0586879,0.01107433,0.1353525,0.06610739,0.041864987,0.14513914,-0.03816942,0.022175828,0.15387087,0.017133005,0.035038363,0.035579737,-0.0010595818,-0.02701253,-0.0038560873,0.07680534,-0.002499958,0.03888728,0.057173956,0.011311357,0.03797516,0.07823401,-0.060941946,-0.11215531,-0.013454741,0.06367335,-0.03121623,-0.019256953,0.008594425,0.07043975,0.015597617,-0.031106163,0.06707018,-2.6951971e-08,0.04685186,-0.076446764,0.0035853838,-0.05978162,0.06650271,0.020497499,-0.029165292,-0.043355387,0.010952584,-0.046872895,-0.07312403,0.08604321,-0.005488101,-0.028790396,0.032273855,-0.007505949,-0.01800284,-0.027339054,-0.0054583936,0.031362034,-0.14448734,0.057650156,-0.08567634,-0.008675171,-0.06847145,-0.04399326,0.047372807,0.046181448,0.029908737,-0.013738126,0.010171987,0.0066393116,0.024492526,-0.016974268,-0.11628002,0.019925863,0.058512207,-0.1424437,-0.053861555,0.0039985743,-0.100251086,-0.011176363,-0.042778503,-0.05557053,-0.0035872697,-0.03859523,0.052551933,0.0016609336,-0.062047634,-0.039080255,-0.020909296,-0.008119728,0.030357627,-0.0054807807,-0.040043116,-0.020597693,0.014298699,-0.0037524698,-0.026189458,-0.09652915,-0.006340126,-0.0027063377,0.15124217,0.017886274 +1.97.1.1,Flavins or benzylviologen can act as acceptor.,384,0.99999994,-0.09380414,-0.058499612,-0.09972337,0.05512308,0.027710125,0.006648555,0.07685195,0.00092383707,0.063272096,-0.043452382,0.0753156,-0.007066781,-0.07259874,0.11241057,-0.0028352547,0.022238249,-0.077774815,0.06661707,-0.059574418,0.075754344,-0.042824842,0.03375384,0.06508382,0.0173837,-0.12057593,-0.0576011,0.003477632,-0.03400526,0.08909139,-0.076527886,0.084296264,0.04549237,0.030504039,0.028807953,-0.051610094,-0.009344299,-0.03217946,-0.056452967,0.022257308,-0.038013604,-0.027983313,-0.041163728,0.054579318,-0.044714667,-0.0051209396,-0.030075638,0.029223677,0.07041181,-0.009360985,0.008516351,0.009972849,-0.004071666,-0.03698951,0.06394049,-0.09569561,0.02606054,-0.123737514,-0.029578304,-0.04219608,-0.051287144,-0.016351959,0.054317508,-0.07291784,0.0469723,-0.047292355,0.018668957,0.0048517324,0.019611835,0.038059983,0.038617793,0.03985661,-0.03655685,-0.0013325502,0.02976898,0.06161427,0.04493922,0.020318849,0.03418545,0.058262218,0.005677283,-0.016820747,-0.025574842,-0.010249536,0.033517886,0.052188523,-0.024014946,-0.114264585,0.06433527,0.032164373,0.10716248,-0.019802801,-0.03909047,0.079324946,-0.039134867,-0.02100145,-0.02392868,0.075394884,0.00022797094,-0.031480107,0.046185203,-0.07483979,0.0049738777,0.02179906,0.012587151,-0.052522574,-0.016677704,0.0053664283,-0.077789955,-0.018942557,-0.093862906,-0.03838721,-0.10320795,0.107890755,-0.06572137,-0.048484035,0.030491175,-0.046267062,-0.070972204,-0.0029417167,-0.012011258,-0.062094852,0.02051331,0.022509221,-0.013031839,0.016527215,0.0046678316,-0.081117,2.0372954e-33,-0.010570953,0.010348806,0.017465645,0.008844296,-0.0139667615,0.032318108,-0.035379212,-0.016865578,-0.0128806,-0.11593909,-0.08423296,0.00554265,0.031520262,0.06798554,0.043427803,0.022354623,-0.01909511,0.037248496,0.034267638,-0.062097438,0.051198844,0.07068127,-0.052966364,-0.008411206,0.008639992,0.033192065,-0.029343234,0.038810175,-0.011918709,0.029071309,0.06140631,-0.017776566,-0.016270773,0.110416725,-0.007035243,0.074637644,-0.05144329,-0.053112313,-0.029128633,-0.07874105,-0.014981376,-0.006444189,-0.14427464,0.0772868,0.05034775,-0.033571973,-0.051839173,-0.037852738,0.013406608,0.04578551,0.043489367,0.002781977,-0.026827384,-0.031860683,-0.00250815,0.029025307,0.0075814095,0.08756425,-0.023763372,-0.023681689,-0.015213828,0.063079044,-0.0030540687,-0.005752252,-0.014342985,-0.008154892,-0.0013247796,-0.07008067,-0.05331409,0.020616034,-0.021453675,-0.017324742,-0.009474966,0.09682636,0.0987941,-0.052684393,-0.0059489557,-0.033726536,0.029847529,0.014457426,-0.091840364,-0.08666101,0.005072141,0.09546465,-0.07276165,-0.0058327573,0.004977868,-0.06243078,0.039732937,-0.026961986,0.007629034,-0.06724606,0.038146373,-0.0009517061,0.00063426496,-3.109158e-33,-0.04402709,-0.043458894,-0.033172213,0.10041044,0.012042259,0.088367485,0.009960176,-0.052839927,0.064733,-0.039578382,0.04869782,-0.0049955286,0.0028672528,-0.0069714584,0.057731405,0.01886512,0.030938614,0.0014662443,0.0021576555,0.022273613,-0.02239918,0.011724682,-0.03464254,0.019183671,-0.030714927,0.029716413,0.010607211,-0.011308052,0.0041576386,0.096944705,-0.037504576,0.056477286,-0.047496643,-0.06916195,0.01277505,-0.0016920939,0.01111226,0.055041194,-0.11892741,-0.019157914,0.0005162535,-0.027201613,-0.0005698954,0.095299736,0.031581707,0.012061935,0.014007438,-0.070432626,-0.022590071,-0.045546662,0.014877559,0.052314747,0.020588597,0.021946311,0.06333611,0.048730817,0.07830361,-0.13236988,0.0048333034,-0.0071321786,0.010546326,-0.10858556,0.036991615,-0.0027503346,0.0583521,-0.010467804,-0.019768782,0.12072043,0.0647352,-0.08818352,0.16519764,-0.07024664,0.054802276,0.105606884,0.023015257,-0.008514232,0.03653738,-0.07626787,-0.020761369,-0.06576912,-0.056827057,-0.014634965,0.07327222,-0.0060121445,0.0069875605,-0.10949007,-0.058980856,-0.047571402,0.019247254,0.07886511,0.023012228,0.06755585,0.030466361,-0.015779117,0.012459736,-2.2994401e-08,-0.03748919,-0.07238904,0.032314837,0.0025315492,-0.024948757,0.042388357,-0.017135238,-0.06667666,-0.07984704,-0.0101488065,-0.025558477,0.072302796,0.046443257,-0.002613895,0.082739115,-0.031240737,-0.027373912,0.047088556,-0.09745365,0.026662873,-0.108374014,0.0761516,0.008330996,-0.06201004,-0.0069436547,0.00349129,-0.040204793,0.016993431,0.042664222,0.0073703257,0.018394148,0.057499517,0.028107792,0.030479,-0.055282153,0.016930608,0.04490609,-0.093065895,-0.07744494,0.045346394,0.030848201,0.0512598,-0.04465492,0.016946092,0.024006372,0.003635173,0.024432225,-0.019010238,-0.006950717,0.013759685,0.050105244,0.05836842,-0.003985367,0.009250041,-0.07046744,-0.009298864,-0.018419866,-6.663107e-05,0.014681058,-0.08987729,0.022007199,0.026688496,0.12783118,0.04283942 +1.97.1.2,"1,2,3,5-Tetrahydroxybenzene acts as a co-substrate for the conversion of pyrogallol into phloroglucinol, and for a number of similar isomerizations. The enzyme is provisionally listed here, but might be considered as the basis for a new class in the transferases, analogous to the aminotransferases.",384,1.0,-0.06675671,-0.07131596,-0.106098615,-0.07067683,0.038338676,0.022547945,0.028101165,0.026184449,0.05986694,-0.046267487,0.016324572,-0.075427696,-0.061641064,0.02866282,-0.05239918,0.013444382,-0.09054849,0.004167946,-0.026393281,-0.06817035,0.05732158,-0.000729726,0.0483444,0.024037318,-0.012760059,-0.030090587,-0.0055670952,0.0009147915,-0.004158569,-0.03973052,0.06253731,-0.014858532,-0.10545341,-0.040685136,0.036750518,0.028104488,-0.0569955,-0.03452534,-0.0036862993,0.012923767,0.06007457,-0.07435995,-0.11092834,-0.0025336102,-0.12829368,-0.019786244,-0.0055175046,0.02852022,0.0053834757,-0.07508116,-0.010801993,-0.081744924,-0.10481018,0.062348273,-0.04006409,-0.0062898095,0.07610375,0.043020125,-0.013893075,0.013221206,0.014900956,0.006383863,-0.03730579,0.02484274,-0.019794187,-0.0074086967,0.021611918,-0.067453064,0.01731672,-0.007551932,-0.086944714,-0.0383264,0.009688837,0.0187723,-0.022974432,-0.060539577,0.009221248,0.010930772,-0.039701488,-0.053998105,-0.018386079,-0.008667206,0.020732773,0.043019388,0.04057715,-0.022291265,-0.11518245,0.033819064,0.08589292,0.036167137,0.018224673,0.06866062,0.00985571,0.04856217,-0.05118766,0.086087584,0.0282228,0.030997481,0.083029754,-0.03597105,0.032050744,0.027113337,-0.035341628,-0.08121513,-0.055822946,0.048303105,-0.0041081375,0.01981827,-0.021052914,-0.08657564,-0.061328597,-0.012261551,0.047659505,-0.027959537,-0.039351337,0.058211215,0.052826315,-0.02692584,0.012665161,0.03779338,-0.017478596,0.01703124,0.05673742,0.046057705,-0.045130752,0.04592833,-0.07987582,1.641383e-33,0.044378504,0.11252671,-0.0026004412,0.07113565,-0.03697367,0.023518398,-0.053508956,-0.02366093,-0.04086634,-0.050696597,-0.077018775,-0.06145041,-0.005516398,-0.006179543,-0.013870932,-0.026058428,-0.06936141,0.055343498,0.042383876,-0.0068395236,-0.02505591,0.11843111,-0.051153336,0.0107015325,-0.0074085356,0.13077821,-0.050191347,0.03837858,0.023192696,-0.0017850129,-0.024327675,-0.061913867,-0.093990505,-0.024967914,0.031027835,0.02908091,-0.023242943,-0.011485535,0.034016594,0.023440339,0.036671575,-0.10147094,-0.037917137,0.032484047,0.09354796,0.0146547705,-0.10349424,0.040730618,0.038598817,0.027503306,0.007352207,-0.07702565,0.036826763,-0.0174001,-0.12663007,0.027698904,-0.016324688,0.017020477,0.05327784,0.01882396,0.03371623,0.080481134,-0.022879323,0.009389881,-0.015353088,-0.018673535,0.0017282501,-0.034642577,-0.041644983,0.0254605,-0.07879384,0.034793034,0.07522456,0.07608147,0.15279692,-0.039895125,-0.01664628,-0.06377867,0.014742663,0.058754764,-0.043065216,-0.011557292,-0.013047473,-0.04060384,-0.1009544,-0.021110084,-0.028452747,-0.06973319,0.0035090758,0.07591251,0.06415404,-0.1142803,-0.029426953,0.031471208,-0.03251176,-2.4570864e-33,0.029399766,-0.0353968,0.058586057,-0.044890087,-0.030611312,-0.026224993,0.026928687,-0.02034854,0.00053722656,0.0649983,0.07465384,0.0035489062,-0.028136611,-0.039477266,-0.020839898,0.005168863,0.003976476,-0.0010454314,0.016831083,-0.028750049,0.038521577,0.019836364,0.0032563547,0.10227825,-0.053329345,0.08615464,-0.024651675,0.013061467,0.12282557,0.08330741,-0.0049708397,-0.012507655,0.09406488,0.04366387,-0.022990393,0.03889281,-0.017505562,0.039526276,0.019373246,0.051745918,-0.03548131,0.012467951,0.035924908,-0.014177288,0.00036225244,0.09916932,-0.04453891,-0.058741905,-0.07798162,-0.04314381,0.011969581,0.1215579,-0.08129891,0.0009774364,0.06212091,0.015857134,-0.011437241,-0.035210315,0.024490304,-0.009704877,-0.028132416,-0.026508944,0.040289268,0.016604604,0.071483254,0.059953738,0.0057412595,0.078210935,0.036231637,0.05712444,0.06408051,-0.007612768,0.011297529,-0.03165516,-0.05165681,-0.043858413,0.012266312,-0.0035850042,-0.04264582,-0.056300793,-0.02868182,-0.02421479,0.06159821,-0.088497534,-0.017787136,-0.10882223,0.030974349,0.073888555,0.027660485,0.0016226195,0.0072707837,0.04161027,0.005129193,0.08748228,0.102808334,-3.7080518e-08,0.029749058,-0.01086182,0.036720276,0.0042836405,0.020630661,-0.002952657,-0.022782473,0.020468712,0.045474734,0.029337313,-0.07098081,0.0114053,0.107154414,0.05753809,-0.023425926,0.09844069,-0.063143335,-0.037448097,0.050653037,-0.049606707,-0.021975903,0.04837046,-0.07398711,-0.022023609,0.016076595,-0.017192913,-0.024830058,0.12075477,0.04360313,-0.05744997,0.0071802265,0.08576771,-0.042140324,0.035683192,-0.009539601,0.086161345,-0.029534137,-0.045674052,-0.04549745,0.06554915,-0.033897437,-0.022313828,-0.03737007,0.022021854,0.07587208,-0.0033068515,-0.021598427,-0.035934974,0.0296277,-0.007142575,0.062008698,0.034169246,-0.014637269,-0.043001264,-0.13317361,0.0010603985,-0.0746127,0.012262101,-0.012522699,-0.11502287,-0.010228515,0.004211518,0.12518337,-0.010513614 +1.97.1.3,"Sulfur can be reduced with hydrogen as donor in the presence of hydrogenase, or by photochemical reduction in the presence of phenosafranin.",384,1.0,-0.024255265,0.03411568,-0.026990186,0.0066899196,0.073785275,0.0650963,-0.015068951,0.02977395,0.012472292,-0.031984758,0.03973259,0.037266463,-0.052313246,-0.0033727144,-0.032410994,0.051525056,-0.028970359,0.05997558,-0.03313882,-0.0701857,0.04869983,-0.114589944,-0.008392715,-0.033986557,0.029293193,0.032867976,-0.024358988,-0.06265587,-0.04642502,-0.016938785,0.024701115,-0.037618585,-0.0077664377,-0.06652149,-0.05501831,0.060438998,-0.03944484,-0.07236335,-0.0075576394,-0.042362537,0.04470425,-0.018725032,-0.10217425,-0.043427926,-0.056735296,-0.04104991,-0.0037789033,0.015226477,0.00029380922,-0.17123601,-0.012873214,0.03794729,-0.095396385,0.044606403,-0.009571092,0.048785027,-0.068074495,0.00953253,0.031454757,-0.063403584,-0.06404858,0.020884942,-0.0013785926,-0.054360427,0.05556693,-0.025688708,0.047589812,-0.043481518,0.06174961,-0.0023663153,-0.03496764,0.029769259,0.0070482516,-0.028376767,0.014092996,0.020599594,0.016711492,-0.03897859,0.053933408,0.021756398,0.010835677,0.026979376,-0.030159816,0.01325532,0.010149824,-0.021014838,-0.030370269,-0.048203062,-0.03337677,-0.04407557,-0.006399235,-0.043628737,0.02539148,0.0020896965,-0.11998266,0.058751002,0.029084424,0.084354274,0.028184727,-0.025355505,0.019404858,0.023573358,-0.08178618,-0.14781229,-0.03986818,0.033422045,0.036698863,0.101448655,0.00016371002,0.020561956,-0.022584904,-0.04538508,-0.012851591,0.021865588,-0.036311254,0.12182164,0.080565855,-0.017398253,-0.15879165,-0.014154234,-0.0059776204,0.045234937,0.07008559,0.0071743545,0.029303325,0.011364477,-0.10265499,-7.169731e-34,0.07923104,0.075951934,0.10028759,-0.115060404,0.024895413,-0.007130991,-0.06798778,0.06676803,0.058649883,-0.0499784,-0.057911362,-0.04400676,-0.010569934,-0.046789333,-0.059645195,-0.036899712,-0.0054515623,0.016479649,0.07183502,-0.0062940046,-0.05212324,-0.010340802,-0.027350549,-0.007143324,0.0150002595,-0.031926807,0.014243316,-0.015974235,0.025940252,-0.024818499,0.04072231,-0.01712041,-0.06676883,0.094418354,0.04238144,-0.037383225,-0.02174204,-0.004971623,-0.026683811,-0.04803636,-0.045771837,0.0074151657,0.035392042,-0.04761908,0.060174722,-0.040143028,-0.018836558,-0.0038344108,-0.0073638447,0.056612264,-0.0025270113,-0.037105218,0.07606321,0.012045688,-0.036597397,0.011117357,0.07348278,-0.07356832,0.024836583,0.018389732,-0.03682358,0.09215768,0.033542555,0.024190873,-0.029213263,-0.002340667,-0.03313415,0.011257775,-0.065814964,0.008764438,-0.07528587,-0.031124543,-0.0045826156,0.026300242,0.027000608,-0.036260772,-0.008017038,-0.026429156,0.028848685,0.020722302,-0.06149005,-0.046877615,0.03383379,0.014974062,-0.033165343,-0.020706283,-0.053537842,0.016975814,0.017725341,-0.014207127,-0.050943978,-0.080516346,-0.027084924,-0.038566954,0.013063606,-1.3747466e-33,0.060963083,0.022559652,-0.026443612,-0.03110816,0.023586428,0.026729928,0.06935265,0.009223813,0.002210822,-0.026001628,0.032454986,-0.04863062,0.02283325,-0.05441625,-0.042796444,0.0920021,0.034740265,0.010299097,-0.062382866,0.023516744,-0.07524611,0.102223225,0.031057766,0.058087133,0.02625876,-0.033397164,0.114096254,-0.006406189,0.104409166,0.03417889,0.013465629,-0.020952446,-0.039551947,-0.09214195,0.017949598,0.007712753,0.049615245,0.018916426,-0.024373075,0.040003683,0.06703944,-0.09836396,0.046478424,0.119352356,0.017728083,0.0624591,-0.07233329,0.027831363,0.008195801,0.011938081,0.0345531,0.0021927669,0.0011771539,0.06708013,0.030498207,0.0008651906,0.07884353,0.0024030774,-0.053298414,-0.0010608034,-0.01589456,-0.09268586,0.03496836,-0.010431019,-0.01676964,-0.0010246675,-0.008084983,0.026822202,0.032697007,-0.05712949,0.057492618,-0.024619548,0.024332762,0.031536862,-0.012562122,-0.058108713,-0.0017721906,0.0113792755,0.052646343,-0.019309599,0.03883369,0.0113994125,0.008614249,-0.17986357,0.07625015,-0.059919577,-0.050631426,0.051141936,-0.05385037,0.012740764,-0.011801488,0.055918973,0.0024309263,0.04727161,-0.029208455,-2.334339e-08,0.0041700024,-0.008180372,0.09751778,0.044077914,-0.0036237715,0.02098974,0.025583837,0.07761042,0.023352183,0.0325459,-0.06802883,0.066594556,0.015781676,-0.023258993,0.028891403,0.009885922,-0.011899207,0.01561693,-0.035253882,-0.039218575,-0.028298773,-0.071110316,-0.14856754,0.08022066,0.11345208,-0.07218058,0.105267026,-0.036003586,-0.03369348,-0.027678171,0.09089031,0.043147396,0.022855591,0.03344043,0.06872905,0.012191129,0.04772982,-0.0072230087,-0.03301207,0.011686443,-0.08760646,0.088333234,-0.087359965,0.0036355844,0.04523637,0.023300989,0.03917803,0.061649702,-0.009050171,0.098864734,0.09186642,-0.039481737,0.005580824,-0.110549755,-0.10901053,0.04980352,0.11348748,-0.0066284565,0.01484151,-0.00045432406,0.10626884,-0.06765106,0.06910775,0.051105257 +1.97.1.4,"An iron-sulfur protein. A single glycine residue in EC 2.3.1.54, formate C-acetyltransferase, is oxidized to the corresponding radical by transfer of H from its CH2 to AdoMet with concomitant cleavage of the latter. The reaction requires Fe2+. The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen radical from the glycine residue.",384,1.0,-0.037707053,-0.016173108,-0.11721906,0.082826816,0.11420159,0.03424896,-0.02899957,0.026894683,0.019179396,-0.063508496,0.05020088,0.063044615,-0.040723324,-0.0034931053,-0.026409606,-0.0068355463,-0.0522328,0.036365006,-0.067546524,-0.013784219,0.016856102,0.012367621,-0.037147302,-0.07179608,0.023177754,0.020212619,0.034044277,0.0004156587,-0.027957775,-0.058471344,0.0052862875,-0.03965954,0.008364702,-0.047968764,-0.010815358,0.08508963,-0.026915662,-0.0673955,0.037011277,-0.016473599,0.015635604,0.007950866,-0.05472167,-0.0569822,-0.023822786,-0.059486143,0.059017655,0.010623354,0.005754313,0.01350986,-0.02236647,-0.010626419,-0.04978353,0.026994824,0.0352504,-0.036376268,-0.03574577,-0.026280839,0.026417993,-0.04146316,0.0028040058,-0.00091224175,-0.03329621,-0.06550862,-0.015907548,-0.07103194,0.14073429,-0.11241733,0.022150073,-0.011413733,-0.067815006,-0.028031776,-0.07242739,0.0014550826,-0.028116265,0.00399929,-0.0526041,-0.0446514,0.11366661,0.004786749,0.020883838,-0.05085702,0.024714042,0.061452787,0.03294547,0.047851723,-0.054264344,-0.02992197,-0.020548673,0.030959275,-0.052187722,-0.051688954,0.01847116,-0.022510104,-0.051176965,-0.01671657,0.051489666,0.093247406,-0.035968788,0.04648226,-0.032084163,0.13319525,-0.07760991,-0.06678382,-0.025204478,-0.037724856,-0.0068541323,0.15172097,-0.02881216,0.023996664,0.03626264,-0.038487613,0.03643335,-0.07143398,0.021233223,0.1483699,0.048025414,-0.058883972,-0.023419367,-0.0215327,0.11192271,0.091372505,0.046790406,0.07687803,-0.05305924,0.033832576,-0.10275792,1.9763638e-33,0.08568975,0.13212855,0.064342186,0.031608388,-0.048642125,-0.03323179,-0.15341017,-0.008151243,0.08690061,0.011162058,-0.04686865,-0.032189365,0.08761376,-0.053740352,-0.05398533,-0.075564176,-0.0017476212,-0.003928259,0.057719704,-9.916043e-06,0.0072776363,0.04492561,0.014800471,-0.027322358,0.036176044,0.038178947,-0.014112726,0.013536208,0.027950179,0.04172184,-0.055115968,-0.06412377,-0.09951413,-0.010373281,0.07394282,-0.036512334,-0.009350577,-0.07775404,0.055372514,0.012404793,0.090463,0.010736379,0.0025068824,-0.029810257,0.05269508,0.022925489,-0.02321152,0.10119183,0.011363275,0.029897472,0.009414339,-0.040188126,0.079919316,-0.025976492,-0.081645295,-0.007787725,0.010196899,-0.03887224,0.028407784,0.16141698,0.02361285,0.056894485,0.008353562,0.03511403,-0.016654387,-0.009557741,-0.12207704,0.038300917,0.006808281,0.052307818,-0.031924296,0.0058434242,0.1441174,0.05123243,-0.012144282,-0.056140363,-0.02662013,0.034887157,0.037706643,0.033474766,-0.078037694,-0.024520762,-0.039305426,-0.025914744,-0.035051,0.044192765,-0.0178848,-0.059680846,0.0012006671,-0.026463766,0.017179118,-0.005125936,-0.023129644,-0.034567494,-0.031888578,-3.5751687e-33,0.015472781,-0.06321774,-0.033824425,-0.03611897,-0.05193784,0.0068247924,-0.006085694,-0.003954651,-0.030262703,-0.01646268,0.068916574,-0.023542697,0.024101317,-0.09997387,0.08106298,0.0064585237,0.0012234441,-0.013475024,0.003085315,-0.0005754823,0.018218784,-0.014752682,-0.008651607,0.026439069,0.026927328,0.021888403,-0.004078013,-0.006006672,0.09745844,0.10839312,-0.0059288065,-0.021016443,-0.0210311,-0.09228911,-0.03592506,0.04207982,-0.028376514,0.0209888,0.0007946695,-0.020784367,0.011802366,-0.019625084,0.0071113613,0.17041692,0.06301401,0.036232073,-0.042016357,0.02129795,-0.011682621,-0.070021205,0.041679293,-0.045387324,-0.05188347,0.015371854,-0.04191815,0.05558741,0.057328988,0.032312352,0.017864447,0.06573124,-0.028969994,0.00282216,0.026572922,-0.021319661,0.04833052,0.0015748771,-0.0076598288,0.0019391975,0.041875865,0.02470347,0.014104905,-0.048253544,0.04166925,-0.01630103,0.041347552,-0.01699795,-0.056936745,0.081071995,-0.02478457,-0.0028100843,-0.02623452,-0.0033916805,-0.029876523,-0.031858996,0.04651877,-0.1108556,-0.031404905,0.13511027,-0.03755039,-0.011059188,-0.12074831,0.006425308,-0.04755349,0.060868308,-0.015537731,-4.1895284e-08,-0.00853423,-0.01872309,0.06210768,-0.0015665209,0.0063224183,0.091584116,-0.028523935,-0.017935792,-0.022473866,0.012209993,-0.034549937,0.124788,0.010794764,-0.06623561,-0.05273237,0.10246697,-0.01409286,0.10274686,-0.009304515,0.0063647293,-0.057800453,0.01976122,-0.04810374,-0.022359211,-0.02554902,-0.060482386,0.020851003,0.0065970966,-0.018233048,-0.059069764,0.016193701,0.02729138,0.001109503,-0.0067870263,-0.0880464,-0.052808728,-0.03333701,-0.020040384,-0.012155541,0.009958001,-0.052896693,0.012068101,-0.10215533,0.06015165,0.023661477,-0.001338898,-0.02484343,0.017860342,-0.092748396,0.019428505,0.023916231,-0.00040318392,0.027909344,-0.06244402,-0.07056781,0.029982246,0.0045279316,-0.05171271,0.06287435,0.012332002,0.0067647556,0.011874457,0.06350043,0.024569765 +1.97.1.8,"This enzyme allows the common pollutant tetrachloroethene to support bacterial growth and is responsible for disposal of a number of chlorinated hydrocarbons by this organism. The reaction occurs in the reverse direction. The enzyme also reduces trichloroethene to dichloroethene. Although the physiological reductant is unknown, the supply of reductant in some organisms is via reduced menaquinone, itself formed from molecular hydrogen, via EC 1.12.5.1 (hydrogen:quinone oxidoreductase). The enzyme contains a corrinoid and two iron-sulfur clusters. Methyl viologen can act as electron donor.",384,1.0,-0.039321195,0.054367602,-0.1383811,-0.04675084,0.09817555,0.031848975,-0.0052304016,0.07347586,0.003495218,-0.027707316,0.008580662,-0.11523892,-0.043874215,-0.009530089,-0.07178853,0.026230562,-0.054278385,-0.0127144195,0.012324671,-0.0645475,0.035683915,-0.009492336,-0.05761637,-0.07721799,-0.067285754,0.065143846,0.009802127,-0.035023503,-0.0049066045,-0.041284956,0.032675877,-0.0142932385,0.017336221,-0.045754313,-0.048701618,0.10538513,-0.055675242,-0.051069017,-0.0052014757,0.1015542,-0.05426038,0.02365239,-0.025427612,-0.00096577,0.0047715623,0.026620533,0.013639223,0.019428458,-0.0055210725,-0.047103602,0.009988832,0.005831414,-0.05055448,0.062479157,-0.00083280256,0.023581462,-0.0051578265,-0.02804164,-0.005805304,-0.031386483,0.09212905,-0.041535497,-0.0042558485,-0.056212507,0.013576421,-0.022060307,0.0054232194,-0.09283149,0.013803734,-0.1113775,-0.026616363,-0.0010236084,-0.04922033,-0.018154925,-0.02423537,0.03329058,0.038348548,-0.0039150855,0.034438018,0.009339842,-0.0047740764,0.0091685355,0.029061481,0.09926125,0.07642772,-0.010686729,-0.016490536,-0.047255997,0.01078604,0.08677356,-0.004765108,0.0203763,0.004301846,-0.040089935,-0.08333083,0.08796665,-0.030384762,0.014548436,0.013592347,-0.034599606,-0.031700615,0.03357882,-0.098397106,-0.109076425,-0.10925815,0.05183462,0.049861316,0.12623087,0.077243984,0.023691928,-0.042391542,0.05900786,0.03398107,-0.037954897,-0.02240886,0.14064485,0.060401704,-0.061746314,-0.06288791,0.029160902,0.038477026,0.017078305,0.041745402,0.010301715,0.021546626,0.040941313,-0.07432078,4.4275156e-33,0.03129328,0.06909113,0.007487339,0.008603679,-0.017564585,0.056213003,-0.097317465,0.023565143,0.008109155,-0.12751785,-0.022134295,-0.09359312,0.006486746,0.00021160964,-0.084682934,-0.038843714,-0.014611102,-0.041937828,-0.009910414,-0.048768163,-0.028819691,0.065677285,-0.049260113,0.0036501575,-0.008124136,0.030093893,0.015113436,0.015507888,0.010413882,-0.018009976,-0.007918835,-0.026127357,-0.082734875,0.037578866,0.060745437,0.05647485,-0.067893766,0.014451113,-0.017839387,0.06376781,0.016038753,0.054558296,-0.03234585,-0.0064314133,0.13546616,-0.07789236,-0.039672595,0.045597024,0.060827732,0.0026469824,-0.022736587,0.021791987,0.05920138,-0.04240269,-0.09928312,0.049537327,0.028814692,0.0050368714,0.0022227245,0.04990071,0.024981273,0.09534727,-0.005837249,0.09931247,0.018528502,-0.019268673,0.0008164003,-0.07214334,-0.013089931,0.034198977,-0.047317084,0.009226156,0.0839875,-0.0066637024,0.026940264,-0.07585334,-0.031131212,-0.033900306,0.08540338,-0.08066801,0.009866513,-0.042693976,0.08755628,-0.09094388,-0.048424482,-0.07114153,-0.03422037,-0.10882225,0.030847033,-0.006349121,0.07245263,-0.103357755,-0.059502054,-0.06017913,0.0039695282,-4.0425063e-33,-0.0039311657,-0.048614487,-0.032726977,-0.04912555,0.0031906762,0.06909359,-0.0022480614,-0.033599667,-0.02128109,0.025125105,0.09142741,-0.029751739,-0.009722974,-0.040074136,-0.0035691205,0.012417924,0.05975466,0.06284459,-0.0004477703,-0.05854872,-0.011141492,0.059898514,0.050147273,0.007784351,-0.018486273,0.039172158,-0.052049838,0.064919226,0.1247469,0.028030504,-0.019851493,0.007368771,-0.04768866,-0.007438112,0.027030569,0.07036709,-0.050358202,0.04607007,0.0591951,0.03132623,-0.015701301,-0.06668547,0.008134113,0.007037124,0.013156327,0.09231361,-0.10210513,0.01626984,-0.004765232,-0.07070415,0.060196932,0.030012865,-0.038408015,0.028086834,0.04751879,0.04739509,0.03598998,-0.012180559,0.020423463,0.010965938,-0.015758058,-0.04821615,0.03490597,0.010047953,0.02109117,0.035159208,0.025694367,0.12624194,0.077742636,0.02134034,0.04605674,0.056389857,0.06445347,-0.03577417,-0.07297374,-0.085059226,0.011785186,-0.022516357,-0.025638562,-0.054334503,0.002370629,0.0016353546,0.020157741,-0.103149444,0.0027426195,-0.1184559,0.007861152,0.07414488,-0.05283682,0.061486192,-0.06486853,0.02438764,-0.062374335,0.05051671,0.07578925,-3.9739803e-08,0.02298809,-0.07026478,0.044488072,-0.0069108866,0.0335099,0.00226176,0.009425582,0.02971573,0.05211777,0.0050260886,-0.0700473,0.052457772,0.069158785,0.009173737,0.064397804,0.05393387,-0.020374903,-0.0033272747,-0.021653924,0.013228105,-0.040368337,-0.0046633654,-0.11803438,-0.00820206,0.014748571,-0.03099618,0.07149158,0.05612272,-0.0062441495,-0.017754938,0.010007405,0.067069754,-0.018156746,0.0060152444,-0.075294785,0.032732356,-0.022312999,0.010766217,-0.012738097,-0.0265138,-0.009482101,0.030402174,-0.085687436,0.07803414,0.047997728,-0.023637252,0.008382376,0.006998425,0.029603807,-0.008439896,0.02796082,-0.009181022,0.06553812,-0.016519677,-0.11068111,0.05697571,-0.00836442,-0.01886814,0.028130969,-0.07932881,-0.011817032,-0.03427669,0.15065151,0.028597347 +1.97.1.9,"The periplasmic enzyme from the bacterium Thauera selenatis is a complex comprising three heterologous subunits (alpha, beta and gamma) that contains a guanylyl molybdenum cofactor, as well as multiple iron-sulfur clusters and heme b. The enzyme reduces selenate to selenite using electrons provided by a diheme cytochrome c4, which receives the electrons from the membrane quinone pool via EC 7.1.1.8, quinol---cytochrome-c reductase. Nitrate, nitrite, chlorate and sulfate are not substrates.",384,1.0,-0.018920394,-0.040568817,-0.091722675,0.00020561644,0.013480843,-0.028779224,0.027565004,0.02279717,0.09125864,-0.073314294,0.027479595,-0.077104755,-0.008658878,5.9171205e-05,-0.066786066,0.0059532714,-0.02493416,-0.029320609,-0.014717246,-0.031157274,0.00026284647,-0.039686263,-0.07032244,-0.038277365,-0.02962019,-0.034897618,0.008769301,-0.056039285,-0.0492623,-0.097681805,-0.017215103,-0.019407358,0.09174829,-0.032146517,0.07348454,0.072607465,-0.012891554,-0.091974385,-0.04085658,0.03056731,-0.031712756,0.04483209,-0.05523065,-0.012955026,-0.04027987,-0.056975164,0.03801521,0.015211373,0.01557572,-0.030418271,-0.0072170254,-0.05526542,-0.08137438,0.066097826,0.024204312,0.010817817,-0.0029194292,-0.011841408,0.0047200574,0.055464264,0.06308145,0.045646258,0.038343985,-0.026159367,0.022163935,-0.046695035,0.065331586,-0.061982848,-0.014559807,-0.080201775,-0.0301511,-0.05022326,0.022219647,-0.042059984,-0.0065088025,0.0067477217,0.04372857,0.0023348755,0.034497373,-0.0068272655,-0.08631282,0.021659194,0.025701238,0.10290748,0.015640616,0.022577645,-0.026310945,-0.038471337,-0.024399722,0.03405474,0.028869336,0.044853628,-0.021099905,-0.07295364,-0.05491433,0.11171465,0.014271392,-0.022163415,0.05445735,-0.015167218,0.03412799,0.11363336,0.020442765,-0.042958252,-0.10023747,-0.011992291,-0.01115302,0.12689316,9.202121e-05,-0.014428611,0.051840186,0.027787564,0.043204695,0.015572184,-0.027902406,0.061104536,0.08213197,0.007642567,0.0027819392,0.07363027,-0.017544407,0.039203573,-0.0014290538,0.044647504,0.0678843,0.02801085,-0.08723169,5.1228025e-33,0.09952691,0.067835554,-0.036712233,-0.016298637,-0.059810255,0.0018850605,-0.096164554,0.04034526,-0.059583414,-0.026434727,-0.024800226,-0.093895055,0.05455406,-0.0693874,0.038698297,0.008027729,-0.049615137,-0.027212834,0.06289667,0.0015941543,0.045309696,0.02417834,-0.036296833,-0.04343491,0.05808593,0.07378456,-0.024645792,-0.020799885,-0.011739024,0.0015622452,0.06268802,-0.062188737,-0.07462244,-0.015909981,0.10287574,0.023937631,-0.0017398343,0.02623296,-0.067561865,0.043282107,-0.017350761,0.09058199,0.029702121,-0.048611674,0.06528356,-0.09253527,-0.020568885,0.12891705,0.0702781,0.018955579,-0.03180916,-0.019586353,0.12616093,-0.066361986,-0.083970405,0.09344873,0.022339448,0.027884895,0.07964875,0.051569358,0.08820377,0.08057706,-0.066437714,0.04506862,0.11173643,0.036600728,-0.060198627,-0.04047596,0.07294673,0.06826376,-0.12311684,-0.003766999,0.08271933,0.006851516,-0.035578605,-0.097344555,-0.059925854,0.005015844,0.05141892,0.024846168,0.010762682,-0.055943582,0.058652863,-0.09025854,-0.00754602,-0.05197207,0.0036149118,0.0014828002,-0.024302423,0.009305795,0.05663668,-0.04284489,-0.093706414,-0.08796798,-0.05188377,-4.4029438e-33,0.07764184,-0.1186823,0.03191431,-0.04820083,0.0056591015,0.0061191004,-0.056611646,0.021450209,-0.0626604,0.0117173325,0.06570705,0.023070883,-0.011246126,-0.06278439,-0.04023621,0.050512236,0.0063839965,0.036567226,-0.016049607,-0.044724796,-0.10294208,0.022629607,0.05269207,-0.019752238,0.018936777,0.014337834,0.006118831,-0.005876679,0.0390629,0.012530737,-0.0011528197,-0.019047583,0.0024645573,-0.093592785,-0.057816375,-0.0047985483,-0.09468045,0.035065763,0.079517394,0.013253936,0.014604211,0.030366931,0.04693777,0.0659215,-0.0029252039,0.07232647,-0.093472816,0.06350984,0.03001152,0.020166632,0.019073764,-0.06526182,-0.050416455,0.0045919614,0.057806823,-0.016076926,0.080948606,-0.020365113,-0.016417135,-0.033942554,-0.0715787,-0.056569334,0.043356124,0.02835541,0.063341506,0.034109358,-0.027433086,0.072821595,0.049352,-0.043265507,0.037906617,0.04319233,0.0020001882,-0.05538339,-0.055209886,-0.050332822,-0.026009217,0.060657647,0.020677013,0.0050638285,0.030594919,0.01387423,-0.026737286,-0.07156957,0.08116164,-0.046143614,-0.0005124162,0.14126988,0.016840609,0.0007736901,-0.018982869,-0.0018625906,-0.009818481,0.029445017,0.069129325,-4.5554724e-08,-0.004467923,-0.014652933,-0.015987195,0.001821181,0.0278955,0.028202929,0.04657198,0.0037562123,0.014133591,0.04561126,0.0057891533,0.094804496,-0.04061766,-0.04280363,0.05889019,0.051621564,0.021490349,-0.024519537,-0.022869647,0.025342219,0.0036698575,-0.029404053,-0.08350083,0.06879438,0.0756714,-0.0335725,0.0041656657,-0.044693016,-0.0074688704,-0.032279156,-0.031646714,0.032676343,-0.010919939,-0.050878666,-0.0663816,-0.034865465,0.021121519,-0.030970577,-0.026859377,0.014670058,0.015487339,-0.022844821,-0.108209945,-0.026367983,-0.009640258,-0.04124757,-0.033879742,0.049696185,-0.00059145014,0.026319858,0.019584734,-0.0963246,0.007984416,0.005784358,-0.08156353,0.038251013,0.08300367,-0.05819543,0.03249654,0.002644362,0.09191862,-0.018798945,0.13904677,-0.04484056 +1.97.1.10,"The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.",384,1.0,-0.030599935,-0.07527525,0.016551018,-0.024574291,0.08080454,-0.0068124495,-0.019780872,0.018943133,-0.019161208,0.0077892146,0.02641971,0.0014701518,-0.045810517,0.0041567152,-0.016731482,0.037957188,-0.048545852,-0.044720005,-0.02629769,-0.09340944,0.011449091,-0.053889543,-0.016438793,0.017323108,0.081547074,-0.023453664,0.04181674,0.005338398,-0.053489197,-0.06073593,-0.0079026725,-0.06323192,0.03611382,-0.034957238,0.03263296,0.07941619,-0.05616087,-0.03883006,-0.017925473,-0.013329402,0.052877672,-0.11646664,-0.057831373,-0.04140837,-0.028490974,-0.06034389,-0.07708058,0.003123199,0.024652671,0.0615715,-0.01783656,-0.048643067,-0.03473254,0.064007126,-0.03249737,0.042353783,-0.055061944,0.09861481,-0.074143894,0.027133176,0.021802418,-0.01826598,0.021118034,-0.03524389,0.11444514,0.046600536,0.033584733,-0.10459515,-0.03737064,-0.047478866,0.05526285,-0.087265514,-0.029245747,0.002374943,0.034919478,-0.068401285,-0.07837738,-0.049040448,0.03164516,0.011204217,-0.03155732,0.0054387907,0.12006519,0.020612137,-0.0015644432,0.071931794,0.026637867,0.019377878,0.0130158635,0.06039109,0.011096556,-0.008210911,-0.09355133,-0.040855218,0.04828743,0.0338441,-0.06552557,0.056737494,-0.002421472,-0.0140911685,0.007025373,0.049645063,-0.13728236,-0.043364003,-0.026688524,0.049103543,0.036586262,-0.008094379,-0.05510693,-0.009550076,-0.008701814,0.007067082,0.029947154,0.05767839,-0.071125254,0.10272028,0.003557801,0.07456686,-0.04359422,0.0036999902,0.09191927,-0.00044672214,0.04597837,0.05514881,-0.032457855,0.051375158,-0.10639052,1.4451627e-33,0.06022222,-0.0055316384,0.05292358,0.016987635,-0.0044307923,0.033243228,-0.053662177,0.07058374,-0.041084882,-0.042285684,-0.04004615,-0.07225046,0.05249771,0.026469646,0.0012428389,-0.09765381,0.04432031,0.03826567,0.027116334,-0.027073205,0.10714305,0.087037675,-0.025323031,0.02964142,0.04640805,0.06010432,-0.04868165,0.08622173,0.014320505,0.023761507,-0.0071509746,-0.14999045,-0.06925914,-0.015348342,0.07776126,0.0026162642,0.020067967,0.01188839,0.015379208,0.06998583,0.0052073738,0.01693937,-0.0072208736,-0.008675152,0.0069920504,-0.024876822,0.021802083,0.021485802,0.043825857,0.019499123,-0.008296019,-0.04857669,0.051900845,-0.049179357,0.014874091,0.017840378,-0.013010013,-0.024652025,0.03164143,0.09287926,0.009193436,0.040871378,0.0110526625,-0.036580145,0.026727276,-0.0025614477,-0.13199598,-0.06842204,0.0036755186,0.082883075,-0.08287342,0.053697545,0.025686866,0.011249563,0.07298303,0.015680404,-0.08597637,0.038776044,-0.015918339,-0.06568748,0.0386002,-0.0397161,0.0137497485,0.0014737237,-0.0026653241,-0.04012479,-0.08381731,-0.07662591,0.017265039,-0.021392241,0.0860841,-0.03510859,-0.039795563,-0.074186616,-0.011743327,-2.3767214e-33,0.031709503,-0.069545336,-0.042848933,-0.04992978,-0.07219303,0.067656875,0.034348164,-0.040900573,0.070171565,0.06127566,0.07406769,0.024483541,-0.05474092,-0.019327406,-0.03607084,0.04580766,-0.0027381878,0.051330756,0.041670464,-0.033786684,-0.05415681,0.07003902,0.058671895,0.0015422748,0.09433053,0.044581477,0.027695801,0.07887483,0.10079028,0.043756507,-0.0687586,-0.033882435,0.0015356106,0.006633757,0.03286596,0.060873993,-0.09102058,-0.010648395,-0.020883111,0.017082157,-0.028098319,-0.006606723,0.05253038,0.011761445,0.0064294245,-0.042999808,-0.103999674,0.124766864,-0.024845552,-0.09208691,0.045974825,-0.044388335,-0.019015424,0.010028008,0.022564828,0.01966015,0.028285148,-0.00762839,-0.07130247,-0.008833195,0.02626882,-0.04146063,0.008594123,0.000401605,0.020446364,-0.004861662,-0.011566109,-0.0049742945,-0.008071093,-0.00034617182,0.04777218,-0.03264397,0.010408694,0.0300039,-0.08229285,-0.0887537,0.0157276,0.0430596,0.059902553,-0.02023828,-0.07974426,-0.015771667,0.0056880265,-0.12646039,-0.0022355537,-0.021486906,0.0029999344,0.1039802,0.025709402,0.03814909,-0.0559994,0.021779273,-0.04147077,0.10996345,0.057551146,-4.083278e-08,0.08474012,-0.09359143,0.063111134,0.007197428,0.07703694,-0.006798723,0.031557895,-0.07279704,0.029861199,-0.035004552,-0.09170862,0.08843646,0.047951728,-0.03122391,0.11160962,0.0032236867,0.026352242,0.050801773,-0.026714105,-0.043814164,-0.044650946,-0.038474433,-0.078631066,-0.035802506,0.02787064,-0.005594127,0.039016634,0.035265572,-0.00021047844,0.016353048,0.00789632,0.0053047366,0.018200044,-0.06252887,-0.05480967,0.010486358,-0.08621878,0.03925775,-0.001466617,0.015969623,-0.048928753,-0.01904867,-0.019381369,0.02793217,0.034864925,-0.0049580657,0.04902002,-0.062278967,0.026185097,0.009249627,0.010538614,-0.02905582,-0.02088939,0.049860872,-0.036374785,0.10000021,-0.0134529425,-0.12667274,-0.021058787,-0.04332886,0.023279944,0.045887146,0.15615101,-0.04200041 +1.97.1.11,"The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine. ",384,1.0,-0.060298316,-0.04396339,0.01130223,-0.014474145,0.09110228,-0.007060706,-0.04620076,0.0058236774,-0.011776445,0.048437823,0.053455703,0.06073386,-0.062329326,0.039288495,-0.030217329,0.027534055,-0.067967534,-0.015921794,-0.062119447,-0.08764446,0.0323316,-0.031954434,-0.04519677,-0.026526682,0.061371725,0.044723604,0.044505432,0.006699746,-0.051710073,-0.09190987,-0.04320324,0.003706099,-0.017462375,-0.07260299,-0.02490301,0.097008035,-0.079485714,-0.016352683,0.054346416,-0.018328859,0.06007851,-0.08068411,-0.12784813,-0.06582315,-0.017243192,-0.013607807,-0.06792832,-0.024413783,0.05203544,0.020482266,-0.019980598,-0.024958763,0.016526733,0.037667766,-0.097173385,-0.010524013,-0.017464135,0.0145563455,-0.046393957,0.03417389,0.0132490555,-0.004407817,0.009694716,0.029569186,0.082738586,0.053261496,0.056311876,-0.035046168,-0.023189457,0.0076602055,0.074142136,-0.10232006,0.004892462,0.033546597,0.0219654,-0.041976713,-0.05487826,-0.062366575,0.042483255,0.027739508,-0.043232072,0.0079017,0.09816078,0.05535215,-0.009300615,0.07119593,-0.024946488,-0.0038636005,0.04093124,0.03915613,0.026945693,-0.008974303,-0.10923488,-0.05879156,0.025931627,0.017228069,-0.08486995,0.01770816,-0.082714066,-0.024381638,0.00046683376,0.0400687,-0.18570964,-0.022189023,-0.021393422,0.021686118,0.0572144,0.009300573,-0.062531345,-0.028916374,-0.05625905,-0.005000719,0.002410137,0.025266783,-0.02760536,0.08756739,0.057164595,0.023438133,-0.015779344,0.004137498,0.041278757,-0.012186337,0.04670302,0.086975046,-0.06829176,0.066621535,-0.08351651,-2.2740818e-33,0.051523127,-0.002986569,0.01841039,-0.020812044,-0.0042732144,0.025421165,0.0046397275,0.021356925,0.034525525,-0.045047045,-0.0022706734,-0.06976821,0.029945293,-0.0869774,0.028935941,-0.046982504,0.0491373,0.05858464,0.013706335,-0.020344552,0.09763848,0.097239934,-0.043701105,0.026856095,0.029366346,0.08498616,-0.007308423,0.018894758,0.00795815,0.027653644,-0.027102003,-0.073957495,-0.048330616,0.027725479,0.104640394,0.018837031,0.014085495,0.043696523,0.04315484,0.09707391,0.0702732,0.011439839,-0.022274837,-0.033722892,0.0030947533,-0.014925034,-0.0006134266,0.018805671,-0.022201328,-0.009279378,0.036414742,-0.010427851,0.06303844,-0.063113585,-0.018118806,0.034987025,-0.01001748,-0.055170726,0.022615395,0.040663406,-0.015124516,0.023946602,-0.011771823,-0.006336607,0.004656002,0.008082078,-0.13887279,-0.0637603,0.018629164,0.07583941,-0.10306443,0.03281239,0.0390236,0.043371916,0.09039601,0.03444557,-0.0964199,0.021181352,-0.008037023,-0.02917946,0.08000889,-0.014879332,-0.018840302,0.044491902,0.03728328,-0.0015739059,-0.024845479,-0.08416882,0.015399592,0.0027472265,0.1632392,-0.046915688,-0.024202188,-0.07413168,-0.065568775,5.70415e-34,0.042005986,-0.09752911,0.04189499,-0.012015276,-0.080719754,0.12442751,0.01044415,-0.0079699755,0.060752463,0.078407,0.084177665,0.054393183,-0.068745755,-0.026740452,-0.04236231,0.07756859,0.025354825,0.06504642,0.031989325,-0.04074943,-0.040386062,0.052263554,0.050565485,0.022549158,0.09098138,0.05666293,0.04557214,0.06794099,0.13620962,-0.02624832,-0.053232078,0.0035121767,0.018867567,-0.040742476,0.071067594,0.037021063,-0.05146541,0.048439782,-0.033642758,-0.024200533,-0.04459644,-0.039743304,0.00078486116,0.045751438,-0.031887066,-0.033078153,-0.07656892,0.07003863,0.011259932,-0.06400693,0.047110327,-0.030848911,-0.044123042,-0.024940412,-0.027921647,-0.0028048349,0.051835533,-0.0063297106,-0.0015366615,0.035275042,0.01983342,0.009009272,0.019406684,-0.032984827,0.049846843,0.039333392,0.015713517,0.041441854,-0.00057086634,-0.04389822,0.03625726,-0.026298162,0.03686251,-0.02456022,-0.03344649,-0.01581309,-0.019322146,-0.046457287,0.032880478,-0.027924255,-0.106868684,-0.03611347,-0.04130448,-0.13742386,0.013719728,-0.078308314,0.032269713,0.11546616,-0.024654286,0.012631794,-0.03209324,-0.03133127,-0.047801815,0.06485357,0.046543185,-3.0950726e-08,0.07045204,-0.076214574,0.04037118,0.023979932,0.020160345,-0.0129736625,0.029951422,-0.042438325,0.081273966,-0.054446097,-0.032538712,0.09572085,0.015937168,0.020508466,0.060151506,-0.03401476,0.0076245586,0.027800182,-0.0019612245,-0.057150856,-0.043326437,-0.033060376,-0.09789404,-0.07569147,0.02869531,-0.008324572,0.07342621,0.035256464,0.011278049,-0.051440388,-0.019293765,0.010755607,0.03136112,-0.004902198,-0.044532184,0.019971443,-0.05068295,0.0022527704,-0.039490126,-0.005943676,-0.045481514,0.011641338,-0.06359552,0.058669873,0.016031364,-0.030086275,0.06256877,-0.024222903,0.026268553,-0.026268471,-0.019124746,0.03616065,-0.030025214,0.013790834,-0.04094946,0.06322365,0.04085243,-0.13516706,-0.058491882,-0.028484477,0.021582758,0.014462061,0.14479701,-0.029827394 +2.1.1.4,"Some other hydroxyindoles also act as acceptor, but more slowly.",384,1.0,-0.049380917,-0.09050538,0.0031030802,0.043077182,0.054415025,-0.09121862,-0.018631501,-0.0064846766,0.03506632,-0.07761561,0.09115908,0.07164459,-0.011829876,0.05364797,-0.04132976,0.04721771,-0.026127134,-0.04207673,0.0055832798,0.03417103,-0.016461356,-0.043703437,-0.002544927,-0.006077886,-0.073122285,0.049998727,0.026871528,-0.0040981746,0.029650304,-0.06604073,-0.06743024,0.0870991,-0.011702239,-0.016312711,-0.11119516,0.042645734,-0.026292913,-0.025955738,-0.025482563,0.02592846,0.06918745,-0.09475323,0.057785433,0.020790653,-0.042612776,-0.064496465,0.04352431,0.00070926617,0.017494142,-0.03252655,-0.06299912,-0.016175147,0.0032859666,0.059123486,-0.04952581,0.03111333,-0.10579879,0.02114778,0.011038425,-0.01705011,-0.035561893,-0.0045714867,-0.04692753,0.052685425,0.03967089,-0.04075033,0.026785586,-0.06922034,-0.0022702608,0.019429242,0.018755605,0.005986845,0.04074056,0.018459443,0.0023519262,0.030302856,-0.012104779,0.014658641,0.07837204,0.034591623,-0.078847066,-0.02951648,0.0038256552,0.07085642,0.05256735,-0.022538114,-0.049043357,-0.024843765,-0.10356,0.020127121,0.040894076,0.023955962,-0.037174374,0.022228193,0.057105944,-0.0046330853,0.08123247,-0.02130393,-0.085474625,-0.014888052,-0.030282896,0.043149844,-0.10076446,0.033120703,-0.047631737,-0.07241442,0.041441806,0.02602139,-0.045605805,0.016967304,-0.056966465,-0.073773846,0.069053754,0.098804876,-0.13352026,0.088441804,0.019363984,-0.016876096,0.06871794,-0.045785643,-0.08274031,0.048116717,0.018451663,-0.06430053,-0.0503087,0.078394145,-0.02427557,-2.5177677e-34,-0.008406967,-0.010881447,-0.031518236,-0.045972567,-0.09416723,0.031795826,-0.09480535,0.022470053,0.0008653826,-0.047180764,-0.09175624,0.036703683,-0.008426849,0.0806246,-0.02350709,-0.11808048,-0.018950442,0.1104206,0.035093494,-0.027064942,0.03916377,-0.023226947,-0.037275817,-0.023487782,-0.08534017,-0.008012406,-0.026871737,0.019839708,0.0064491346,0.016139662,0.03573586,-0.009118515,0.016935367,0.0050903405,-0.033604722,0.0510132,0.040097848,-0.026346315,0.01835002,-0.027056873,-0.037318528,0.029264703,-0.022633146,-0.014950828,0.0563249,-0.023511764,-0.04896334,-0.01278778,0.004743487,0.047398135,0.023425559,-0.0041534407,-0.0073623112,-0.065848045,0.0126188705,-0.014497915,0.030284092,0.048978288,-0.07065545,0.025343271,-0.061014365,0.078515835,-0.04036534,-0.011435061,-0.009919556,0.062737614,-0.02089876,-0.051388897,-0.08922084,0.04808722,0.005688764,0.040158927,0.05711386,0.033892903,0.070838034,-0.06694718,-0.01661125,-0.0076766163,0.04732908,-0.06633325,0.014440935,-0.019167872,0.05746785,0.10514771,-0.03167753,0.022788936,0.029810207,-0.032218445,0.052838847,0.0037705423,0.05431273,-0.051785916,-0.06536426,-0.051940575,0.051628705,-1.5762757e-33,0.03349165,-0.10025172,0.039389547,0.01284276,0.072339505,0.09196499,0.080709964,-0.0078067007,0.12055574,-0.032820236,0.12880042,0.05858006,-0.0162091,-0.0463578,-0.004324208,0.0062345057,0.0034905153,-0.0073725185,0.015181994,0.0014457899,0.016251912,0.05459657,0.051447302,0.07301812,0.003817418,0.002917749,0.07172471,0.045556996,-0.08493981,0.07056353,-0.033872865,0.029524557,-0.08924146,-0.020612499,0.02853714,0.08015493,-0.16111714,0.036379725,-0.042496096,-0.036451105,0.0041595176,-0.044355188,0.057716552,0.0050642192,0.003701933,-0.034866277,-0.00068272656,-0.011800635,-0.04760718,0.032316927,-0.05035236,0.04203385,0.022121487,0.07504872,0.04957614,0.008160334,-0.050946496,-0.06787688,-0.01805804,-0.01665407,-0.011646312,-0.0031831544,0.035755143,-0.053370237,0.007216009,-0.01332744,-0.009183386,0.03375747,0.10068728,0.010143781,0.14299113,-0.032222375,0.059770856,0.075769015,0.0380922,-0.037630104,0.014636763,-0.07389768,-0.08737807,-0.042811003,-0.037467897,0.1201215,0.0069447383,-0.09029664,0.002618118,-0.0100247,-0.03734929,-0.008020306,-0.004359519,0.12338782,0.07505232,0.0036769747,-0.050802622,0.009416231,0.08389974,-2.251305e-08,-0.007093178,-0.023627965,0.099683374,-0.017731039,-0.024856811,0.033026926,0.00021003302,-0.001545893,0.032713454,-0.09506385,0.047682375,0.08410829,0.094394796,0.0014726084,0.06463415,-0.01977172,-0.023383932,-0.021584991,-0.062068313,-0.029710805,-0.14601813,-0.02208645,0.035375886,-0.03486098,0.0034829248,0.035905723,0.022657951,-0.05744316,-0.000349817,-0.015426123,0.029248904,0.013181324,0.039500043,0.021720441,-0.020917574,0.11874978,0.052529003,0.025018938,-0.034050427,0.010507037,-0.017001309,-0.082517125,-0.049625568,0.0024938744,-0.020593096,0.023032295,-0.018569766,0.05021966,0.0125973895,0.019384291,0.03171356,-0.032184165,-0.0044547077,-0.08656688,-0.05462048,-0.038803395,-0.06303255,-0.010329337,-0.018743295,-0.057693664,-0.022308972,0.0152270505,0.13408306,0.019144181 +2.1.1.6,The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.,384,0.99999994,0.083871126,-0.07161603,-0.061341904,0.021791045,0.0042172056,0.046901885,-0.036406957,0.033965193,0.05602652,0.015392445,-0.023604263,0.00067555,-0.108597234,0.053934995,0.028308703,0.0067801015,-0.039184157,-0.02189392,0.036315396,0.027774878,0.006417238,-0.08805469,0.008505861,-0.001294973,-0.015104748,0.056422953,0.017799193,-0.008699604,-0.030331591,-0.026891118,-0.02709219,-0.08771487,0.04181194,0.013357022,-0.025920847,0.06441145,-0.078110605,-0.023551838,-0.005310458,0.08972487,0.029892743,-0.05007936,-0.06903773,-0.005837884,-0.01267267,-0.035333212,-0.007155111,-0.042065278,0.011666224,0.013557514,-0.047387477,-0.046347473,0.005075746,-0.02749088,-0.035454966,0.062753506,-0.06416543,-0.015666857,-0.017307224,0.048508037,-0.09811762,0.11490002,-0.0020543516,0.055799432,0.109221905,-0.022513542,0.056251414,0.012689742,0.03014957,-0.023237288,0.014303944,-0.04573539,0.016012596,-0.0313124,-0.028802948,-0.07115123,0.008541464,-0.019063387,0.04656672,-0.017930882,-0.004130605,-0.035802357,-0.022847522,0.015437637,0.012830751,0.03672124,-0.010390131,-0.03874333,-0.0073961113,0.07227459,0.047533527,-0.06280017,0.0107380375,0.006210512,0.019064749,-0.033288047,-0.04044779,0.01769173,-0.023176845,-0.029224733,-0.0052262857,0.06901263,-0.09847847,0.043582294,-0.03229965,0.053981133,0.020211918,-0.010387345,0.03842427,0.06107072,-0.027731003,0.018093487,-0.0325652,0.07247865,0.059068188,0.08634494,-0.056313574,-0.012888259,0.007014064,-0.0004000695,0.012379491,0.00951333,-0.0070050657,0.05544847,-0.036790594,0.06886934,-0.023891676,1.7093424e-33,0.08968803,-0.045101594,-0.010427511,-0.07170361,0.01847605,0.05914089,0.009336226,0.054391533,0.021139441,0.010551459,-0.12043654,-0.0031647764,0.04253531,0.084380224,-0.015084652,-0.060617246,-0.03835984,0.024853287,0.10182971,-0.021456134,-0.00055978884,0.0036432494,-0.015137947,0.09399735,-0.030990219,-0.02871564,-0.08490404,0.1188905,-0.03287906,-0.022376223,-0.013590086,-0.07024348,-0.036687884,0.04315284,-0.025994092,0.007706786,0.010772489,-0.0054975166,0.06417728,0.028108334,0.015999844,0.01733997,0.012583807,-0.033501137,0.029808763,0.009383394,-0.096239656,0.013514479,-0.013387576,-0.00033317966,0.059398085,-0.0037306785,0.07961534,-0.006903151,-0.027719729,0.050270747,-0.022708256,-0.015953356,-0.008763472,0.08841944,-0.015155304,0.08999821,0.1221769,-0.011379011,0.034428928,0.053184893,-0.030896777,-0.053923097,0.028627144,0.09644913,-0.047729928,0.03656588,0.04004361,-0.0854434,0.08327337,-0.025342379,-0.08667512,0.037415594,-0.076068036,-0.07063604,-0.0021764264,-0.059989486,0.012060428,0.043693487,0.008316508,0.022565382,0.06296966,-0.083659016,-0.038858447,0.07399894,0.040434916,-0.014313496,-0.05290976,-0.017589794,0.07746481,-3.4841777e-33,0.053650122,-0.12048082,-0.018248057,-0.026161067,-0.06313321,0.093067914,0.04631432,-0.0511284,-0.045597102,-0.011647381,0.031194251,0.027020527,-0.0039848695,-0.061827935,0.013604757,-0.0044959527,-0.062001616,0.0986123,0.05399457,-0.03845178,-0.051089644,0.034654044,-0.06366403,0.07946338,0.10308425,-0.05264661,-0.028673897,0.0029881527,0.045401413,-0.09026373,-0.009605534,-0.0055953157,-0.06603902,-0.01556724,0.0015407956,0.066512845,-0.019433687,-0.04077378,-0.0149892755,-0.058378987,-0.013810375,0.07866926,0.012778648,0.038563676,-0.009110665,0.034307007,-0.049307358,-0.08059612,-0.064359896,0.02355085,0.017457832,-0.046634074,0.019748747,-0.0018340527,0.016778762,0.004398397,-0.015337238,-0.10504971,-0.0137398485,0.0032296993,0.0056491047,-0.0077103213,-0.053326916,0.03455168,0.03002569,-0.061929505,-0.007645822,0.04800322,0.071293324,-0.0046860836,0.10020884,0.033281032,0.050830677,0.09183007,-0.06491249,-0.0019727526,0.044521067,-0.045396496,0.0515399,-0.09647975,-0.0016813953,0.05375072,0.015412448,-0.08778013,-0.13374983,0.037189573,0.042330552,0.105515815,0.01332456,0.06807151,0.04517563,-0.032961763,-0.002610968,-0.084192365,0.056206528,-2.6279922e-08,0.05738769,-0.03836874,0.018974585,0.018232757,0.00443103,0.038870122,0.021425484,-0.012119262,-0.060145296,-0.096475706,0.023596829,0.06222725,0.06441402,0.06280419,0.038023524,-0.02850917,-0.028225647,0.0011866626,0.0032779905,0.04751485,-0.08534609,0.0062176883,-0.11932123,-0.01526519,0.058586083,-0.0808421,-0.023037191,0.10937873,-0.024587134,0.019599773,-0.03472012,-0.054020476,0.021680994,-0.08004424,0.08755843,0.016023705,0.025471222,-0.082567126,-0.022396907,-0.03611333,-0.04731518,-0.14233258,0.021781387,-0.03306594,-0.047131866,-0.053937275,0.04957752,-0.037103493,0.09974411,0.0035673373,0.014891759,0.037204944,-0.0018985491,-0.0836761,-0.030804865,-0.01305861,-0.13937367,-0.0877144,0.004153958,-0.061945505,0.08232908,0.014852614,0.09595075,-0.04468377 +2.1.1.9,"H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors.",384,1.0,-0.014997034,-0.023773314,-0.049585,0.005632939,0.05299441,-0.014842034,0.026777543,-0.0061596436,0.032080393,-0.00335743,0.061497,-0.01094914,-0.080869764,0.04226349,0.05357942,0.06789693,-0.046084817,0.035644863,0.038753476,0.02280945,-0.04077939,0.030593956,-0.037711546,0.014884623,-0.11128505,0.0014173537,0.015345834,0.04667565,-0.024096172,-0.11636068,-0.04324802,-0.033313733,0.026044019,0.0026403007,-0.07330094,0.002037742,-0.08570498,-0.00839767,-0.007352879,-0.038264647,0.07907916,-0.107478164,-0.008569298,0.015488072,-0.08382683,-0.047806323,0.037900504,0.07050919,-0.008993783,-0.008913334,0.030397544,-0.013314954,-0.015282115,0.13496448,-0.112148084,0.054449305,-0.1415503,0.067022614,0.017601514,-0.04089148,-0.014906953,0.0046873265,-0.038953383,-0.0032607669,-0.031813703,-0.003521072,-0.04031568,0.036869477,-0.020257957,0.045761146,0.04257933,-0.009891015,0.01893507,0.02460127,0.055010576,0.043184537,-0.0405766,-0.034934565,0.078678645,0.008999582,-0.054494843,0.0163426,0.031474143,0.10109594,0.075416505,0.0014467617,-0.0981245,0.07385486,-0.10622672,-0.033782598,0.027065657,-0.04210068,0.085349105,-0.06253631,-0.012025365,0.017734721,0.13581127,-0.024535568,0.046754256,-0.019887466,-0.0125602,0.008741396,-0.038130827,-0.0550949,-0.03905146,0.059688114,-0.03551098,-0.0047089146,0.007986509,-0.05418351,-0.079175144,-0.077198334,0.054881237,-0.030172106,-0.073324576,0.040391445,0.0066481563,-0.036982812,-0.015810078,-0.12640701,-0.0664845,0.031832553,0.05222859,-0.009535176,-0.037688483,-0.003716104,-0.057871748,3.0097098e-33,-0.00969801,0.040997077,0.0028772159,-0.017077591,-0.00771434,-0.028493373,-0.06917818,0.024806421,0.014222924,-0.03344004,-0.07772384,-0.052100126,0.025474604,-0.0061620288,0.023750002,-0.07378141,-0.0052731037,0.08371183,0.08155316,-0.021331787,-0.038968746,0.07122571,-0.09014068,0.011507575,-0.041716382,0.016325744,0.058004625,-0.023895517,0.07059627,-0.0031701936,0.034443483,-0.004830924,0.018042235,0.009030543,-0.014835044,0.09437237,-0.020441134,0.04518614,0.018515952,-0.09461041,0.020929683,0.037729487,-0.046890337,-0.025713684,0.030167287,-0.040718213,-0.03001268,-0.014239587,0.008846429,0.021812428,0.030663433,-0.09395895,-0.014092661,-0.033195034,0.008303592,-0.021179633,-0.009003483,0.059724573,-0.018732587,0.04720111,-0.0040607774,0.04476571,-0.007211418,0.00841953,-0.10010415,0.026302686,-0.090125956,-0.06497399,-0.070234716,0.09464773,0.0033625155,0.055280015,0.06213153,0.013488797,0.02128138,0.0074526453,-0.014129494,-0.036533274,0.05809759,0.07390726,-0.016054086,-0.06691848,-0.02884118,0.07789877,-0.051701806,-0.0763658,-0.0075636604,-0.04344264,0.03497838,0.023980325,0.02298376,-0.014328247,0.0077118366,-0.021663154,0.051463038,-4.7487474e-33,0.06670827,-0.05816242,0.08220205,-0.0037333416,0.049166482,0.11195028,0.019529328,-0.08534387,0.07268338,-0.014551528,0.12960315,0.028858561,-0.006153581,-0.044381104,-0.016326202,-0.038718864,-0.037264373,0.049276922,-0.008495739,-0.023462895,-0.043533694,0.015698718,-0.0045082816,-0.003475059,0.00914076,0.04035188,-0.03245698,0.039706245,0.07619179,0.12426459,-0.014096716,-0.0131125245,-0.03129608,-0.008785579,0.091090284,0.031153768,-0.04177635,0.065329,-0.051758602,-0.008591237,0.012139764,-0.08971891,0.0414291,0.12836137,0.052997824,0.05473313,0.018386941,0.02791411,-0.02193702,-0.092776805,0.015584929,-0.0076494124,-0.04669745,0.040992547,0.041088406,0.091969155,-0.007467033,-0.06721142,-0.0034201553,-0.0817138,-0.07592427,-0.047930032,0.041233413,-0.05812428,-0.070318036,-0.089097776,-0.08281448,0.008756155,0.0075921924,-0.007278879,0.10203227,0.004013407,0.028991735,0.043425508,0.10231706,-0.067818046,-0.007241589,-0.07188423,0.004647045,-0.023028167,-0.02691979,0.06933568,0.013441037,-0.0363851,0.03801827,-0.016823776,-0.021932246,0.035133544,-0.054836042,0.090601236,0.015236198,0.07853992,0.007947338,0.063905016,0.036767833,-3.2711196e-08,-0.039207272,-0.061751343,0.02898758,-0.044452645,-0.07364372,0.048836894,-0.014482654,0.03953545,0.03897008,0.0075892545,-0.011159279,0.09329665,0.058884926,-0.040508334,0.052568622,-0.02212401,0.007193635,0.0018098252,-0.025320748,-0.052812945,-0.091807365,-0.010151545,-0.009902296,-0.011672483,-0.028737312,0.006316776,-0.022172915,-0.07447878,-0.0076185493,0.012485308,0.09160757,0.036813524,-0.0121114,-0.012808707,0.09348489,0.054613113,-0.01458132,-0.006544864,-0.057830572,-0.042638462,0.010459545,-0.028744983,-0.12185577,0.024260769,0.006398611,-0.036417067,0.01660152,0.056885067,-0.079356655,-0.007900907,-0.02563898,-0.057593003,0.049078554,-0.03768845,-0.05337738,0.015285986,-0.0071474947,-0.046409983,-0.018132167,-0.07875509,0.054129094,0.06658505,0.13243172,0.06835231 +2.1.1.10,The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine.,384,1.0,0.0074788006,-0.03240581,-0.073147275,-0.02248563,0.055483498,0.040051077,-0.11578809,0.079981744,0.029312506,-0.003214025,0.02488873,-0.03488798,-0.01989176,0.053204264,-0.0052230153,0.07108637,-0.038708337,-0.021416025,0.002414534,0.007527631,0.056900267,-0.014391981,-0.03682602,0.003760499,0.11128658,-0.014376305,-0.018019976,4.3161268e-05,0.013363965,-0.005430981,-0.04309754,-0.012059017,0.04287893,-0.007763522,0.044274695,0.10484996,-0.049272515,0.01981879,0.01083445,0.027280057,0.06619878,-0.024471369,0.01485253,-0.021096194,-0.044158217,-0.029201869,-0.020398045,-0.009992974,0.00990493,-0.020745361,-0.030186107,-0.067047134,-0.05152918,-0.0030019335,-0.0037691954,0.08502362,-0.008386139,-0.0048822383,-0.04495518,-0.008613055,0.014382185,-0.029593669,-0.018382123,-0.01851153,0.090225555,-0.09358352,0.04387986,-0.09759481,0.04510878,-0.017138679,-0.0064173853,-0.055785064,-0.0036827198,0.054890525,0.005691721,-0.05618533,-0.0035910234,-0.013093226,0.07996048,-0.03558257,0.036919583,-0.003491477,-0.020780386,0.007007499,0.07448172,0.064180925,-0.041269165,0.016487518,0.06949778,-0.0015199274,-0.022428324,-0.012195546,-0.046467222,-0.10150927,-0.058936805,-0.020492762,-5.831961e-05,0.07676794,-0.051769316,0.0022874523,0.048128895,0.0544193,-0.14322582,-0.07029923,-0.057408676,-0.0028662353,0.04238604,0.026437731,-0.029940682,0.011927378,0.080466025,0.04545537,0.087802544,0.013254241,-0.050427407,0.08782657,0.015644593,-0.047094587,-0.040305268,0.028023742,-0.02228413,-0.04151197,0.0995159,0.03956244,-0.024447829,0.03429844,-0.05811628,2.1650847e-34,0.04869178,0.05233483,8.715319e-05,-0.04575388,-0.0023167315,-0.015705103,-0.040207148,0.04172782,-0.03225799,-0.06685241,-0.1155534,-0.08055047,0.02730042,-0.0007993473,-0.08467452,0.031698406,-0.010447889,-0.008626662,0.00969548,-0.043768696,-0.0058451374,-0.039856452,-0.01939116,0.03721604,-0.0016768586,-0.036140658,0.019156324,0.038569465,0.03842296,0.0037004263,-0.03452104,-0.016015925,-0.03525546,0.025271613,0.02573706,0.067080036,-0.060865827,-0.048908226,0.059659626,0.0739103,0.030324021,0.030267622,0.050790265,-0.04282809,0.026023079,0.0022836197,-0.08003317,0.018031597,-0.028841116,0.07843354,0.04503045,-0.08106606,0.041352347,-0.044061325,-0.13099825,-0.018933756,0.015359529,-0.05126787,-0.016666444,0.0882178,-0.04004812,-0.005456241,0.014002812,0.047436815,0.020232715,-0.0062788962,-0.05543234,-0.028333863,-0.020488145,0.08170344,0.0022242542,-0.036067765,0.06200349,0.0313028,0.012715616,-0.05999339,-0.040616553,0.06551435,0.07143284,0.0042899316,0.0375812,0.013525526,-0.018498123,-0.05079127,-0.07763676,-0.028318357,0.00436754,-0.08466972,-0.00031485697,0.017396724,0.053527556,-0.102950126,-0.020926436,-0.03948935,0.019066164,-1.8529103e-33,0.016661486,-0.052372873,0.05577159,-0.07340638,-0.01128626,0.07214452,0.048469156,-0.08734157,0.061990302,-0.032387316,0.13732624,-0.01540778,-0.0138219185,-0.055826265,0.06611691,0.010376703,-0.03069247,0.0070780404,0.021300033,0.0003370111,0.019178474,0.054972976,-0.015925732,0.062978804,0.06270657,-0.043076187,-0.065505154,0.07838898,0.107117906,0.020246785,-0.028908478,-0.027791047,-0.09213004,-0.028279588,-0.006110561,0.109607644,-0.033167325,0.014222063,-0.0056134006,0.03036983,0.019508453,0.053066686,0.020679818,0.104140714,0.014060589,0.06453171,-0.08412063,-0.069628745,0.016620293,-0.12616356,0.06938002,-0.06852385,-0.0038378006,0.015826404,-0.035405386,0.10789903,-0.006413817,0.013008933,-0.10654804,-0.086162955,-0.06799318,-0.06924714,-0.05352138,0.013425498,-0.03796665,0.027088113,0.026000056,0.018520802,0.011455724,-0.037444696,0.028430128,0.027431404,0.078944445,0.06192887,-0.0896534,-0.042106755,-0.08246112,0.0025123246,0.01773834,-0.07197504,-0.01199939,0.02843676,-0.018937198,-0.031123117,0.0045605013,2.520121e-05,0.040607516,0.078405276,0.0105462605,0.06075557,-0.07561103,0.058459118,-0.0072655478,0.0027575425,0.06045502,-3.1041246e-08,0.08745116,-0.13454923,0.012380111,-0.037566125,0.0038246936,0.09186319,-0.039546356,-0.019009907,0.06234949,-0.0038154984,-0.0737516,0.10294177,-0.03102521,0.05420009,-0.006148821,0.019773394,-0.040241215,0.047683533,-0.02209834,-0.034045,-0.106473036,0.030747307,-0.07260537,0.008940363,0.009770518,0.022133099,-0.007904599,0.14563031,-0.008317672,-0.036221772,0.079681344,-0.011131743,-0.057602584,0.042101543,-0.065170534,0.0150476415,-0.025916165,-0.02319136,0.0028969462,0.05083951,0.0662606,0.00965104,-0.06498372,0.07177155,-0.019582365,0.0052959947,0.002024929,0.03827056,-0.014041333,0.050032448,0.0720766,-0.04815539,-0.03534159,-0.08124849,-0.04317681,-0.050680302,0.0011191517,-0.045006525,0.04397789,-0.045544747,0.061372127,0.019720154,0.17858793,-0.036561955 +2.1.1.12,Requires Zn2+ or Mn2+,384,1.0,-0.110670626,0.0006978345,-0.020952636,0.038075943,0.048726015,-0.046783924,0.0021471549,0.023203846,-0.035645235,-0.011937215,0.040245175,-0.031360082,0.035033192,0.074594766,-0.017422372,0.023828372,-0.02304792,0.012738687,0.01295116,0.013188011,0.07045806,-0.016849607,0.043258112,-0.073288254,0.04197093,0.0135460915,0.029566007,0.029327022,0.119578175,0.004790547,0.005382945,0.060324673,0.03596328,-0.04721979,-0.012631317,0.008426903,0.01045556,-0.042702623,-0.052229118,-0.037190564,0.023166627,0.04259823,0.082739234,-0.015040381,0.053539094,-0.018568158,0.09455487,-0.05401477,0.018713962,0.044051718,-0.049435977,-0.024210678,-0.033597108,0.067595914,0.019657452,0.06302001,-0.15517943,0.036301196,-0.009724664,-0.0056746313,-0.010408302,-0.046009246,-0.035304762,-0.0286939,0.12336833,0.025144164,-0.028650075,-0.05359046,-0.034267876,0.035380688,0.024592247,0.031776108,-0.0546593,-0.029993394,-0.04263345,0.01447196,0.063665494,-0.11448721,0.022559393,-0.016823635,-0.07168537,-0.009432144,0.01933058,0.025799926,0.113451906,0.08064372,-0.005206969,0.020190142,-0.046915974,0.0154254325,0.04803025,0.06822106,0.057750285,0.016916197,0.03546006,0.03310367,0.018056365,0.039882474,-0.06670256,0.10133978,0.03142127,0.027293853,-0.002788715,-0.036091965,0.005751209,-0.01545794,0.08402191,0.024009628,-0.06120631,0.066622786,0.06271435,-0.013847005,0.0084498385,-0.052441727,-0.011293786,0.030487979,-0.0013519335,-0.03260738,-0.032178655,-0.0035716915,-0.0006861833,-0.019085761,-0.08799978,-0.010334011,-0.086988956,0.0049254126,-0.044458766,3.921518e-33,-0.025306487,0.057668254,-0.057541206,0.04242026,-0.01644703,0.081214614,-0.03449433,-0.025402416,-0.018626677,-0.07108325,-0.10450598,-0.08326359,0.0044494015,0.06646218,0.0063414495,-0.111146785,0.053685516,-0.044317696,0.078746244,0.0342705,0.06682999,-0.03858534,-0.034502197,-0.017822528,0.0035355038,0.092265844,0.13124755,-0.072871014,0.041511923,-0.024386724,0.05280708,-0.08673211,-0.0682271,-0.01855924,0.070939444,0.0526825,-0.075540364,-0.0061876453,0.0317406,-0.082314424,-0.03169104,0.04619155,-0.14211495,0.03598756,0.067889355,-0.06250889,0.026395798,0.0804218,-0.03230067,0.023912322,-0.0057169753,0.026364831,-0.055210244,0.015330896,-0.04768213,0.0028794026,0.051491912,0.043339916,0.043187708,0.017688733,-0.018594041,-0.03380325,0.042197373,0.081042476,0.03904657,0.072329044,-0.07493692,-0.06373208,-0.002278698,-0.015852647,-0.03038229,-0.07055894,0.07760813,0.09725415,0.05086452,-0.034652796,-0.023342812,-0.049576316,0.0669214,0.023504794,-0.07035115,-0.009036927,-0.018650277,0.032379124,-0.058171522,-0.040299032,-0.013445241,-0.06414748,0.047923997,0.026372911,0.024007393,-0.07012627,-0.0029579932,-0.032741144,-0.027148664,-3.8382624e-33,-0.07712684,0.02483259,-0.0156593,-0.033577017,-0.026982836,0.029852603,-0.0030451347,-0.19663839,0.020337153,0.0061828564,0.059740342,-0.021702634,0.024517125,-0.01448884,0.026952889,0.009468559,-0.039610453,0.013173999,0.099926144,-0.008928203,0.013504379,0.08885989,-0.006979615,0.05838677,0.0035076793,0.07911733,0.0008684646,0.032030806,0.028058866,0.06604534,-0.056450587,0.006596869,-0.0791132,-0.10879361,-0.043525822,0.006167664,0.039630335,-0.030618658,-0.08541059,-0.011471571,0.046360042,-0.050340086,-0.0010202222,0.13094412,-0.021534935,-0.036381315,0.039961163,-0.056019083,-0.0036976826,0.02517532,0.013790389,0.010741571,-0.089163244,-0.08192494,0.034127202,-0.013723143,-0.0017728949,0.03764005,0.052289072,-0.051447175,0.024990182,-0.074531764,0.0395009,-0.06565167,-0.014286151,-0.03715193,0.045282464,0.08509294,0.028661834,-0.017266622,0.030084908,0.12723595,0.13004185,-0.019918175,-0.07092144,-0.012533139,-0.028315052,0.06339732,0.054198977,-0.10541939,-0.031306554,0.021007003,0.009657558,-0.020416366,0.01896811,-0.08391489,0.06835517,0.008847668,-0.07402084,-0.0071728467,0.006677102,0.010319582,0.0023707617,0.04325019,-0.08967882,-2.083539e-08,-0.04643903,-0.05314697,0.026888158,-0.08064598,-0.00936649,-0.0022751233,0.022141924,-0.027824631,-0.008487158,0.019693414,0.06612892,0.02893551,0.0033020945,-0.010918569,0.054949116,0.005913036,0.030227095,0.011662022,-0.076596834,-0.05964766,-0.032014236,-0.0133744525,-0.059831727,0.06014392,0.034235716,-0.009925956,0.00018397722,0.07132403,0.037756972,-0.02868052,0.016570764,0.016907094,0.09207973,-0.06403553,-0.011627038,0.05536538,0.027280869,-0.031397205,-0.0062248744,-0.09563218,-0.10629841,0.019095387,0.045844078,0.021347705,-0.045018494,-0.08930779,-0.018838955,-0.05257366,0.021542462,-0.009812009,0.006685026,-0.07197194,0.02541994,-0.05754565,0.0047211456,0.026706805,0.018971363,0.036512256,0.007187275,0.007867636,0.05883534,-0.013007904,0.0030355335,-0.07405462 +2.1.1.13,"Contains zinc and cobamide. The enzyme becomes inactivated occasionally during its cycle by oxidation of Co(I) to Co(II). Reactivation by reductive methylation is catalysed by the enzyme itself, with S-adenosyl-L-methionine as the methyl donor and a reducing system. For the mammalian enzyme, the reducing system involves NADPH and EC 1.16.1.8, [methionine synthase] reductase. In bacteria, the reducing agent is flavodoxin, and no further catalyst is needed (the flavodoxin is kept in the reduced state by NADPH and EC 1.18.1.2, ferredoxin---NADP+ reductase). Acts on the monoglutamate as well as the triglutamate folate, in contrast with EC 2.1.1.14, 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase, which acts only on the triglutamate.",384,0.99999994,-0.0281689,0.033293158,-0.09881114,0.026752006,0.09296391,0.093928136,-0.06980098,0.057734974,0.019766914,-0.014087905,-0.025936449,-0.00936893,-0.023450403,0.010536421,-0.06702925,-0.003922717,-0.031941265,0.007268667,0.0015163667,-0.020054115,0.015039807,-0.028943704,-0.038605746,-0.0048512933,-0.002697832,-0.013218058,0.013221822,-0.055407602,-0.053437363,-0.026508583,0.0068920087,-0.041365135,0.054331895,-0.020756988,-0.026313271,0.08528262,-0.0008518643,-0.033004817,0.0628464,0.054994684,-0.0055245403,0.013019984,-0.0033331087,-0.028825184,0.027851356,-0.0061962013,0.01600253,0.0062010917,-0.036724024,-0.046022583,-0.059043687,0.0113623375,-0.03137017,0.07722012,0.040046338,0.011096068,-0.022114024,-0.037123706,-0.0022654117,-0.05486497,0.0086427685,-0.10782468,-0.008326395,-0.009958168,0.011003327,-0.04118823,0.060986426,-0.10549597,0.0051809954,-0.05658035,-0.024197923,0.0026648683,0.01035712,-0.016327133,-0.038146324,0.012165721,-0.0020116104,-0.02741871,0.051796082,0.02469847,0.0707737,-0.0050561745,0.01973118,0.042002987,0.056803588,-0.04242813,-0.11311129,-0.025679952,0.008218052,0.016761145,0.029685402,0.046526305,0.02526806,0.009524844,-0.10753746,0.015311306,0.07352446,0.07155984,0.0044443686,-0.00793188,-0.034218423,0.034956887,-0.06722547,-0.0857546,-0.07359035,0.0083310045,0.080628246,0.14020954,-0.017747546,0.025871985,-0.00551077,0.0074086143,0.014095913,0.020561755,-0.01310749,0.14201884,0.09064079,-0.046845138,-0.06777718,0.015939943,0.020895334,0.0017928231,0.14310579,-0.002557801,0.00028127214,-0.018923178,-0.08131597,4.1119634e-33,0.07234299,0.07479639,-0.0630833,-0.028166529,0.032608088,0.02698377,-0.034387648,0.027270744,0.02475251,-0.098878644,-0.05600039,-0.005518672,-0.0003867663,-0.03283141,-0.05608943,-0.048363496,0.01267731,-0.11141089,0.023816423,-0.032462616,0.039937105,0.005148648,-0.0244787,0.09643902,0.036817282,-0.0052551,-0.050160408,0.0074295774,-0.035660356,-0.005295572,0.0038713564,-0.039890207,-0.096383,0.044980954,0.08703805,0.00673599,-0.11999183,0.01926632,-0.010938596,0.04476623,-0.047437344,0.0019097886,-0.036848843,-0.036985524,0.09805377,-0.0623465,-0.08014932,0.08936553,0.027581066,0.09507874,0.08033031,-0.029850626,0.07733162,-0.010468368,-0.09542472,0.010129528,-0.023302615,-0.06950591,-0.00926856,0.09522043,0.035559677,0.03908084,0.0029109349,0.08895728,-0.026121244,0.007646628,-0.05775616,-0.07481564,-0.009318101,0.058073815,-0.0024382551,-0.0095667625,0.0786685,0.0711902,0.044504177,-0.045384448,-0.018324621,0.0062047485,0.036708534,-0.0277748,0.0288341,0.012353973,-0.00020517438,-0.009176137,-0.011556497,-0.0057493076,-0.020917732,-0.0327297,0.006743689,-0.037672844,0.052498076,-0.10180813,-0.03654121,-0.065544836,0.040150106,-4.3312107e-33,0.08681006,-0.034102302,0.028871458,-0.08422007,-0.049089324,0.07903803,0.078695826,-0.1009461,0.031258557,-0.08597586,0.07537845,-0.008603345,0.0015304685,0.073520444,-0.010376992,0.023318369,-0.015496384,0.020462535,-0.014108087,-0.07166246,0.0006927117,0.052212898,-0.048404545,-0.023506505,0.0609512,-0.025226692,-0.055178806,0.05411926,0.12404205,0.050055526,-0.050509606,0.0154014835,-0.07746593,-0.074556455,0.010051787,0.093888484,-0.10514552,0.0073876497,-0.030742021,0.032811273,0.07745165,-0.041825388,-0.049921438,0.06935184,0.10712652,0.091298304,-0.12808813,-0.007375721,-0.006989078,-0.018979002,0.02623447,0.015524269,-0.05668176,0.0049732467,0.05455622,0.037377734,0.08573396,-0.012073957,-0.021249121,-0.02337987,-0.026630634,-0.09621902,-0.0038565095,0.043802034,0.032516427,0.004852124,0.07740895,0.08519812,0.081901066,0.01250849,0.04874281,0.030375186,0.058714148,0.0020651321,-0.06431905,-0.016763786,-0.06358739,0.02504606,-0.016134426,-0.04744617,0.013048722,-0.008379363,0.021675864,-0.059019584,-0.047827642,-0.06295892,-0.028461607,0.026276458,-0.031096276,0.056601036,-0.06537982,0.009349586,-0.009992141,0.01916993,-0.028502664,-5.4392377e-08,0.047109514,-0.016716968,0.043313764,-0.01050566,0.07623275,0.067208506,0.04464472,-0.05729243,0.019594232,-0.063404106,-0.053254876,0.13387306,0.042939443,-0.0042295945,0.022331327,0.006497142,-0.048845574,0.004174436,-0.004995185,0.01205653,-0.038555443,-0.015939293,-0.15104842,0.06630154,0.021217829,-0.07056946,0.029983042,0.044697713,0.003972887,-0.07949849,0.06343455,0.04230809,0.10798881,-0.008703372,-0.111473,-0.03027047,0.0149120875,-0.012289098,0.013432166,0.024203448,-0.046079747,0.04439288,-0.06431805,0.025232263,0.06853986,-0.0011211273,0.02101516,-0.0031726793,-0.001168983,0.028705254,-0.018041011,-0.013526935,-0.016100373,0.010572898,-0.052917145,0.031909782,0.01826966,-0.0021089702,-0.017666118,-0.068450876,-0.02639324,-0.0015994901,0.11040147,-0.03241918 +2.1.1.14,"Requires phosphate and contains zinc. The enzyme from Escherichia coli also requires a reducing system. Unlike EC 2.1.1.13, methionine synthase, this enzyme does not contain cobalamin.",384,1.0,-0.086223766,0.013542869,-0.009875484,-0.049688213,0.048295345,-0.007990622,-0.08128922,0.029789547,0.019492911,-0.058500648,0.002683575,-0.09504166,0.0148519715,0.011120182,-0.006947713,-0.085244894,0.0430617,0.009416854,-0.012091572,-0.08105762,0.027011909,0.05991407,-0.028251344,0.0018484109,-0.007298102,-0.009381005,0.02929067,-0.0051036347,0.026182413,-0.010548901,-0.033991747,-0.030989662,0.07307466,-0.050356574,0.01675752,0.084658004,0.062401358,-0.06079047,0.042655803,0.03543658,0.0072733085,0.096051864,0.042895284,-0.015737904,0.06981994,-0.03628376,0.044644415,-0.0039911666,-0.047417548,-0.100937806,-0.15349099,-0.038440384,-0.0249725,0.0013601666,0.033412475,0.020627584,-0.06815279,0.014262751,-0.021099828,0.00041035577,0.0041024154,-0.07521515,0.031374734,-0.026412047,0.078949645,-0.04310696,0.058363322,-0.06912445,0.015039553,-0.007890865,-0.04613002,-0.0043038917,0.007996236,0.034563467,-0.05669388,0.07107282,-0.011106197,-0.081494674,0.041192193,-3.3269591e-06,-0.015815154,-0.065761596,-0.040305384,0.047987398,0.037248194,-0.01268676,-0.051410746,0.0058039855,-0.05268673,0.04513496,0.046867717,-0.021546086,0.07280997,-0.037537083,-0.047256626,0.043135077,-0.00643261,0.08896986,-0.011481498,-0.029976843,-0.034665816,0.09060428,0.016206399,0.008642722,0.000190179,-0.031080948,0.12222848,0.12776706,-0.020071968,0.06466378,0.055115398,-0.025956586,0.0032227358,-0.03998497,-0.015768217,0.056179356,0.09715618,-0.0485529,-0.08166556,0.06848816,0.041114055,-0.07286008,0.04987095,0.006366914,-0.015285335,0.03354114,-0.029593121,1.2076163e-33,0.04398174,0.049259424,0.050644126,-0.05014209,-0.0027997026,0.030838076,-0.097929426,0.052237988,-0.018069359,-0.122758634,-0.0320071,-0.008794408,0.032572042,0.019135822,-0.04066948,-0.04453325,0.0090481145,-0.060310565,0.09010177,0.032600578,0.068223335,-0.0478161,-0.010658535,0.061276887,0.011019718,-0.01977009,0.011122345,0.03786004,-0.041003037,-0.011309467,-0.045556925,-0.0681169,-0.07477991,0.02837524,0.084434316,-0.039000846,-0.056492884,-0.008548333,0.016991653,-0.043298397,0.008400695,0.034618665,-0.03865066,0.022969265,0.10088542,-0.058245804,-0.05620545,0.10023743,0.018728608,0.05355451,0.05589395,0.030415647,0.044850435,-0.02564774,-0.042226143,0.008915268,0.034433592,0.016312907,0.003337497,0.109354846,-0.018842317,0.056539975,-0.027107704,0.11817757,0.020484244,0.02975493,-0.07175474,-0.05532712,0.0032876828,0.06308121,-0.04200064,-0.06526391,0.012338846,0.10615679,0.036433328,-0.07408439,-0.051797364,-0.03514599,0.07223997,-0.05511407,0.0033848516,-0.047547206,0.003730663,0.003797334,-0.06604838,0.010461866,-0.0008244641,0.03582791,0.06341456,-0.012454699,0.035695307,-0.0751334,-0.04702999,0.035560675,0.004497103,-1.7254802e-33,0.024116244,0.007327143,0.026833894,-0.07854514,-0.074736394,0.017741907,0.048000026,-0.13570155,0.14178227,-0.048005745,0.11682451,-0.0597702,0.02868781,-0.017589575,-0.03968749,0.060369264,-0.048877675,0.050294727,0.020831678,-0.017396653,0.009753783,0.038913738,0.026773168,-0.007944195,0.0063452846,0.07015793,-0.03189972,0.085883185,0.04697559,0.04919511,-0.045280147,0.015150863,-0.03630179,-0.10438193,-0.12561592,0.008928873,-0.029814838,-0.012794925,0.0056427824,-0.010817115,0.014980888,0.050454076,-0.009055597,0.081670284,0.026820118,0.112592146,0.03284951,0.0056630475,-0.030993808,-0.036929566,0.039844826,0.001421551,-0.062091652,0.013821356,0.021368705,0.00033786966,0.0070954477,0.039644424,-0.0192437,-0.06572561,0.02810232,-0.047053058,-0.019580832,-0.004428007,0.046318468,-0.022075823,0.05590865,0.09209387,0.04364199,0.00086156756,0.018381082,0.02706942,0.08318961,-0.05337746,-0.04985118,0.06182396,-0.114265785,-0.012333356,0.018007671,-0.056355182,-0.022664692,0.04351706,-0.039110366,-0.015919367,-0.0037531622,-0.024858566,0.008492837,0.0036180157,-0.033318557,0.099112906,-0.11223451,-0.0236406,-0.011901793,0.057610672,0.0075349403,-3.014353e-08,0.074798934,-0.0585275,0.035895836,-0.045603544,0.04179316,0.041684527,-0.02637897,0.0048928577,0.119126946,0.041147307,-0.034506645,0.061912656,-0.0103158085,0.016300417,-0.009916834,0.026287295,-0.027002767,0.012291255,-0.031802032,-0.0015431083,-0.023328826,-0.027279517,-0.090619005,0.025131343,0.03526928,-0.08555981,-0.032252926,0.023998413,-0.05860074,-0.048154883,0.022133771,-0.02341973,0.09951845,-0.051475894,-0.10075528,-0.023303926,0.0014160322,-0.05430685,-0.014887166,-0.025722131,-0.038029242,0.006455349,-0.11027608,0.022066377,0.043320645,-0.024710376,-0.012086187,0.033833183,-0.024327405,-0.00603306,0.04429126,-0.08445957,0.03631248,-0.066495776,-0.030933145,0.02093049,0.022667028,-0.06060197,0.007234083,-0.03029166,0.027075753,0.002914784,0.17105183,-0.06867499 +2.1.1.15,Oleic acid is the most effective fatty acid acceptor.,384,1.0,0.006215475,0.0011215105,-0.036362067,0.029022286,0.06263691,0.023545641,-0.06263051,0.07917581,-0.005956538,-0.070797995,0.049850844,-0.004257398,-0.0712871,0.01452572,0.07990268,-0.012776266,0.08446527,0.031120496,-0.039630786,-0.03993916,0.00043834382,-0.01786051,0.061471354,-0.03222057,-0.0615092,0.006079642,0.01478549,0.010558777,0.008426104,-0.07315842,0.061168917,-0.0375864,0.0738682,-0.04830266,-0.09916142,-0.039214924,-0.052057352,-0.07053964,0.023614848,-0.0109552415,0.03568878,-0.06168005,0.05177795,-0.078600705,0.0073658144,-0.066696696,-0.023407096,-0.009064014,0.032726213,-0.034254335,-0.03497302,0.020999152,-0.04218526,0.026753532,-0.07922384,-0.018741025,-0.0630861,-0.061727587,-0.034346513,0.0018467442,0.0027697065,-0.0064728563,-0.00089351874,0.025975717,-0.07411522,-0.020832473,0.0007583839,-0.08409794,0.0102527095,0.016951194,-0.028198335,-0.012852712,-0.024640802,0.06382211,0.05377325,0.107083775,0.01866713,-0.06177525,0.09213768,-0.009260886,0.023748498,0.02228535,-0.055879828,0.081338085,0.09634121,0.011018522,-0.02198822,0.033542648,-0.04973696,0.05968308,0.06550704,0.04407738,0.018528283,0.024092924,0.0006076829,0.006123734,0.0050827693,-0.019602153,-0.031140564,-0.041745335,-0.07758588,0.03161974,-0.08472751,-0.086352475,-0.09863944,-0.014258828,0.025259525,-0.015025519,-0.008648042,-0.048867505,0.01123992,-0.09006995,-0.004281511,0.039860424,-0.094594486,0.015077812,0.064478524,-0.08721371,0.019439397,-0.04536227,-0.062084045,-0.08065101,0.06067874,0.009421375,0.00703335,-0.025265343,0.021410773,-9.5039205e-34,-0.048593514,0.014770903,-0.006880552,-0.07218638,-0.015849903,0.01963707,-0.0859802,-0.03201856,0.037198473,-0.06974968,-0.042328406,0.047872573,-0.004681241,0.11109976,0.0032538269,-0.066025,0.037858263,0.120053135,0.01564471,-0.05113217,0.023094164,0.06217479,0.05516153,-0.092471436,0.007958339,0.009663622,-0.036328588,-0.026983188,0.040293906,0.0044794283,0.03651397,-0.071383744,-0.018517837,0.0516626,0.00042438225,0.07478812,-0.07092623,-0.020223062,-0.0063249595,-0.00094647834,-0.011378554,0.05711905,0.03825049,0.070704795,0.0039162524,0.06307401,-0.071454495,0.04814215,0.04843245,-0.009597053,0.0054474156,0.009816587,0.015204751,0.00064675556,-0.013148557,-0.037846103,-0.013088774,0.039542418,-0.023512911,0.016760722,-0.09284078,0.10146068,-0.046130363,0.035127502,-0.037681483,-0.04835276,-0.06384603,-0.04618976,-0.07211978,0.011843737,0.07654835,-0.0022060452,0.10562954,0.042162478,-0.019775875,0.023019705,0.028933007,0.05005145,0.037503503,-0.017070884,-0.001865878,0.0021626996,-0.03412679,0.045532856,-0.09728493,0.07269611,-0.0776953,0.04601236,0.08742024,-0.008400509,-0.035652205,-0.044237703,0.0031408079,0.058123626,0.008773935,-4.234171e-34,0.11018463,-0.10018708,0.0810441,0.039587397,0.085490994,0.024954032,0.04264064,-0.077013634,0.1264259,-0.0014308431,0.0807648,-0.027475568,0.07409663,-0.02893187,0.030854141,0.025240894,-0.020956462,-0.00071640196,-0.062704585,-0.014034256,-0.0036102075,0.031517014,0.0032697138,0.11253525,0.07516644,0.04327855,-0.04393184,0.023921965,-0.034686644,0.007915816,-0.026636278,0.045944687,-0.025660736,-0.06651948,0.033286378,0.047749978,-0.011639712,-0.02826902,-0.034530625,0.068595365,-0.0016263671,-0.014235711,-0.0023605537,0.004460523,0.0650323,0.031297386,-0.012651691,0.020760842,0.008220619,-0.009632436,-0.003958872,-0.0049718744,-0.0234249,3.582032e-05,0.1051304,0.13137428,0.060008086,-0.037041284,-0.09353436,-0.10474646,-0.059817057,-0.024782225,0.07530407,-0.04741724,-0.014581355,0.051883005,0.021267263,-0.0133684715,-0.026654001,-0.044299014,0.061241485,-0.004283431,0.0165125,0.053758502,0.015094859,0.014508425,0.00047097518,-0.08349861,-0.021209972,0.025731906,-0.061687525,2.084106e-05,-0.014195741,-0.06097469,0.05136575,0.053832546,-0.0625986,-0.10747409,-0.009630422,0.060288463,-0.05220435,-0.03966696,-0.0036773523,0.034383763,0.00497773,-1.7106004e-08,0.01799675,-0.048944067,0.065788954,0.014499409,-0.09928019,-0.05904344,0.015043504,0.018735524,0.008976726,-0.10226646,0.011236212,0.06455771,0.024497738,0.015776636,0.038050745,-0.068064824,-0.0070840353,-0.017286394,-0.036461093,-0.07126319,-0.07498628,-0.030441526,0.06583744,-0.06728209,-0.014506348,-0.01062929,0.0053207693,0.0073792166,0.02148371,-0.014746726,0.037329562,-0.0548074,0.028955607,0.04906008,0.14372535,0.061499804,0.06616319,-0.027854053,-0.08251799,0.1387421,0.059351914,-0.0005719813,-0.047860943,0.011859877,0.050820854,-0.01731555,-0.006271009,0.09215684,-0.03496562,-0.01570921,-0.027890628,-0.021202693,-0.057614032,0.032582697,-0.025857126,-0.07168953,-0.050276294,-0.01610597,-0.0064709713,0.011564281,0.04885495,0.052647773,0.17712899,0.07612801 +2.1.1.16,"The enzyme transfers a methyl group to the 10-position of a Delta-olefinic acyl chain in phosphatidylglycerol or phosphatidylinositol or, more slowly, phosphatidylethanolamine; subsequent proton transfer produces a 10-methylene group (cf. EC 2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase).",384,1.0,-0.07175499,-0.046874084,-0.113076344,0.013192433,0.06574883,0.06224087,-0.0047518183,0.028885495,0.035601158,-0.07725053,0.11577386,-0.034085292,-0.060563195,-0.025523437,0.010014059,0.0025734173,-0.09124114,-0.012062277,-0.07018429,-0.09416945,0.026395425,-0.02393637,0.024202315,0.0023431606,-0.049731094,-0.047587276,0.026855158,-0.051788103,0.040229768,-0.038679294,0.019004531,-0.005832868,-0.019002244,0.00079542835,0.013162177,0.05682039,-0.02889494,-0.03373372,-0.013398697,0.045154076,0.11463889,-0.022325099,0.0031183923,-0.0058154063,-0.06903869,-0.036842294,6.696802e-05,0.026958572,0.025147596,-0.035606578,0.000702715,-0.07530058,-0.063966274,0.06340519,-0.06919017,0.10998121,-0.032473646,-0.04011135,-0.0478313,-0.017291518,-0.0014505376,0.06926815,-0.023439972,0.05462795,-0.036528412,-0.045982584,0.08155675,-0.058580004,0.021427529,-2.9281175e-05,-0.06308386,-0.09651386,-0.065267675,0.015180848,0.0117134405,0.002692585,0.026940737,-0.0560477,0.06424375,-0.038760822,0.02046457,-0.026078016,-0.03847107,-0.013128823,-0.0062882756,0.0032393308,0.009423857,0.06343652,0.012819011,0.022455495,0.0111982515,-0.032592084,0.019404577,-0.03858504,-0.06438329,0.063144565,0.058179133,0.005791081,0.069319315,0.019974563,0.05545507,0.07297853,-0.045917824,-0.056812666,-0.061363336,0.0012291786,0.019692682,0.026572524,-0.039228577,0.00021736234,0.02280145,-0.0022387297,0.069137685,-0.024394881,-0.012049986,0.009226128,-0.034930497,-0.021457095,0.024165938,-0.057910085,-0.01879529,-0.024152372,0.021920148,0.058185764,-0.03592029,0.06607868,-0.13415834,4.0322028e-33,0.030269183,0.029242245,0.036247067,-0.064700596,-0.003992351,-0.028952166,-0.05616599,0.06921026,-0.0647328,-0.030049456,-0.056173187,-0.123464376,-0.0015541613,0.08458064,-0.071604975,-0.07122606,-0.01821374,0.09378283,0.05080326,-0.03206513,-0.053971905,0.066026434,-0.0120863905,-0.034881182,0.032462183,0.07209244,-0.11399746,0.01689066,0.020782867,0.0078936545,-0.035049077,-0.041470792,-0.11017937,0.032559995,0.012310496,0.055973683,0.016753832,-0.04704549,0.07124125,-0.01114698,-0.0033083225,-0.021225167,-0.024151558,0.00095429405,0.03070002,0.014964049,-0.10457273,0.04728052,0.05368705,0.020232892,-0.05148963,-0.030654093,0.09535064,0.0052929465,-0.03602831,-0.019883785,-0.043008413,0.024427867,0.00821966,0.0006672443,0.028566027,0.11542834,-0.08482633,0.027910473,0.033462398,0.03578126,-0.031700555,-0.032339074,0.008095675,0.07250217,-0.0035292294,0.0058119795,0.011043778,0.030264946,0.104612224,0.023012215,-0.05471689,-0.03134385,-0.029726734,0.07848493,-0.0022203017,0.017730514,0.024666369,-0.01193344,-0.034453183,-0.014248023,-0.016722772,-0.03644364,0.014016002,0.013878594,-0.03720724,-0.077961415,0.06405449,0.090696804,0.0005216095,-5.5895484e-33,0.062670216,-0.056695513,0.059133094,-0.1051126,-0.0072547817,0.038532715,0.07418585,0.024958445,0.037580468,0.0033204935,0.040142626,0.04541793,-0.004586653,-0.08043982,0.020060906,-0.01109348,-0.018013803,0.08658087,0.059354536,0.02848658,0.0055012107,0.016785396,-0.021039052,0.15638958,0.07134831,-0.0061684186,0.016446065,0.04958414,-0.005333429,0.03212478,0.0025297129,-0.039506488,-0.04305248,-0.011580523,-0.04919102,0.04519883,-0.066338696,0.03937176,-0.023727713,0.09312147,-0.007869821,0.0062765097,0.06929125,-0.018678382,0.04590988,0.086793974,-0.061289836,-0.021078466,-0.051581614,-0.04322643,-0.009803793,0.05997598,0.026894888,0.04354025,0.029410895,0.13234554,0.024070777,0.034454416,0.0019116228,-0.17024933,-0.10322837,-0.06988295,-0.017938362,-0.0047545633,0.012245094,0.04301727,0.043527704,-0.028662961,-0.0015130827,-0.02305325,0.037611168,0.06375011,-0.00013353932,0.044021454,-0.064260125,-0.069155544,-0.0073190634,-0.07103264,-0.018389178,-0.027676294,0.064149626,-0.036049347,0.029008716,-0.0698322,-0.03656359,-0.02031083,-0.0037316466,0.04976083,0.026464948,0.009720112,0.007474893,-0.010577383,-0.045790654,0.006518429,0.031147292,-4.521635e-08,0.055727903,-0.089888535,0.05738022,-0.07015565,-0.025463464,0.011088682,0.015462159,-0.035660475,0.034709696,-0.024485037,-0.018733555,0.05638208,0.07292335,0.062295508,-0.0014385234,0.02852663,-0.07422495,0.034288716,0.034780096,-0.07278525,-0.07370914,0.022988016,-0.03146039,0.035529952,-0.023532392,-0.010862764,0.024592277,0.087036006,-0.017271664,-0.016592732,0.025154848,0.040595844,-0.075688794,0.10890418,0.04601144,0.009492194,-0.03719918,-0.049660083,-0.025605045,0.047269333,0.015752219,0.029127719,-0.045390237,0.03650774,0.045605104,-0.03129263,0.018796027,0.058768053,0.024369247,-0.014464282,0.041983128,0.023840975,-0.08029686,-0.07246259,-0.08127703,-0.07599379,-0.08278814,-0.0771318,-0.06655687,-0.032518905,0.060877662,0.08542349,0.19864517,-0.083436206 +2.1.1.20,"This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate [4]. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase.",384,1.0,0.021532763,-0.017584896,-0.13830648,-0.039078593,0.037993383,0.05381784,-0.053330414,0.019448992,0.033180654,-0.025565084,-0.0104445,0.019361071,0.02023291,0.06054106,-0.032186348,-0.034850925,-0.059994005,-0.0073008547,-0.028096016,-0.108178236,0.019962506,0.0412172,-0.02081657,-0.036266945,0.01788836,-0.012956704,0.035674505,-0.009339393,-0.08322971,-0.020114454,-0.049161755,-0.042103965,0.033602785,-0.035782225,-0.06097139,0.08529994,-0.0026365072,0.046399746,0.025073724,0.04790889,-0.016438343,0.028563475,-0.004110111,-0.063606024,-0.036414098,-0.09055918,-0.00943501,-0.03628224,0.010924822,0.028101485,-0.0347493,-0.021596989,-0.006231037,0.052797284,0.10515795,0.027980402,-0.1341463,-0.053286057,-0.019324223,-0.090957366,-0.03561916,-0.02875663,-0.018500974,-0.013513158,0.036168985,-0.074388646,0.1006162,-0.105299704,0.018792264,-0.04110171,-0.05516362,-0.10109562,0.040337894,-0.0070865853,-0.06879676,0.039145134,-0.041816305,0.008637673,0.09729692,-0.058239065,0.028702129,-0.01361954,0.039139718,0.047858458,-0.018994303,0.035763048,0.014924139,0.0053955563,0.09062397,0.034249205,0.00879284,0.00858747,-0.04603036,-0.059466127,-0.042464145,-0.07267953,0.010530812,0.004958673,-0.054852407,-0.0013000051,0.07134845,0.0977507,-0.08696647,-0.02406209,-0.036012802,0.017818885,0.015814729,0.09226201,-0.064380094,-0.018320063,0.049538124,0.1064785,-0.010652214,-0.0005305599,-0.012614664,0.101726726,0.070554085,-0.081143945,-0.09510549,0.023356713,-0.01764956,0.0043959315,0.04891664,0.010554112,0.020411829,0.058852665,-0.018989027,1.7094465e-33,0.063061915,0.01296931,0.032884408,-0.022251496,0.078277774,-0.034056205,-0.05112504,0.08794786,0.021726435,-0.0122395875,-0.067370914,-0.034174,0.0016254808,0.07188829,-0.023742883,0.03682169,-0.02085473,-0.06514905,0.072013356,-0.053348586,0.0024931876,0.0130444085,-0.0190125,-0.03860459,0.027085256,0.061970506,0.0053887405,0.042490266,0.059600838,0.039294824,-0.040873308,-0.06677291,-0.06444746,-0.008814356,0.017162304,0.039249975,-0.07009143,0.036656816,0.07985619,0.14084458,0.11239153,-0.028502913,0.009899182,-0.036393978,-0.03528042,0.005198975,-0.044196602,0.059704058,-0.04088624,0.10364707,0.0548666,-0.061152592,0.04439985,-0.03274373,-0.055740133,-0.014198143,-0.011219491,-0.07465862,-0.014966583,0.10523643,-0.02614094,-0.030773256,-0.042129003,0.0468211,0.016266627,-0.0301597,-0.11386223,-0.08156747,-0.050099395,0.024643272,-0.010718162,-0.049362153,0.1416394,0.026704118,-0.026447184,-0.0199101,-0.060089797,0.049269713,-0.0065650926,0.011765835,-0.0013531885,0.018629152,-0.03355277,-0.007388766,-0.07623589,0.036546033,0.040193126,-0.08603785,-0.051316787,0.0024601358,0.018281732,0.011324889,0.012210413,0.01139938,0.031606186,-3.7139355e-33,0.05914936,-0.0648199,0.06073184,-0.08030952,-0.011794497,0.041982193,0.03190627,-0.03860881,0.03066656,-0.04468885,0.06258702,0.02064525,0.04800144,4.9834496e-05,0.0026163955,-0.019122392,-0.0044963257,0.046016075,-0.013905678,0.009073409,0.020102538,0.027903998,-0.025358563,0.07378561,0.0432743,-0.010668395,-0.0204084,0.048069354,0.0036643436,0.09287083,0.0013075946,0.0025940898,-0.06880529,-0.03308936,-0.023589144,0.098490864,-0.07173867,0.028237412,-0.05037561,0.053291474,-0.033697844,0.046348125,0.010035762,0.10763354,0.045782603,0.05478217,0.00921437,-0.011587722,-0.03860609,-0.06500059,0.036652114,-0.029416787,0.053139206,0.005174796,0.04659593,0.08696792,0.01839705,-0.065824725,-0.012835396,-0.019246101,-0.0636461,0.0041451785,-0.0075555085,-0.01647938,0.095501795,0.0016903327,-0.0045196903,-0.026377067,0.05562776,0.034878053,0.04031246,-0.06453758,0.053536523,0.074437514,-0.06350899,-0.006161881,-0.0827106,0.036443792,-0.025851052,-0.009810249,0.022333039,-0.033550397,0.0005321802,-0.10925375,-0.059158873,-0.043628536,0.014517125,0.123184614,0.006994281,0.048360128,-0.060952306,-0.013197256,-0.07993039,0.00037275467,0.020638121,-4.152208e-08,0.02988757,-0.14633618,-0.029272629,0.004548432,-0.041377705,0.11277236,0.0459376,0.011724494,0.08585516,-0.02581913,0.0014951483,0.07265136,0.035652786,0.042493664,-0.063838385,0.08837456,-0.057066604,0.040410116,0.00014089547,-0.06978424,-0.12336784,-0.02457576,-0.04903658,-0.030509437,0.035419527,-0.0070603183,0.022915678,0.115926996,-0.028815165,0.005519973,-0.006037678,0.020096095,-0.04526855,0.017556064,-0.07340739,-0.041366816,0.0456583,0.030981766,0.009704108,0.023862803,0.05231497,0.015091234,-0.10162047,0.03394153,0.00686792,0.0034595774,-0.015650064,0.035394996,-0.022166828,0.0075039053,-0.007305957,0.021500072,0.019614505,-0.023707716,-0.03994545,-0.03666779,-0.07524505,-0.064143084,-0.02938738,-0.01191148,-0.04176581,0.06710647,0.112578385,-0.058022827 +2.1.1.25,"Acts on a wide variety of simple alkyl-, methoxy- and halo-phenols.",384,1.0,-0.06520529,-0.11232873,-0.010908277,0.03530465,0.064601846,0.07473726,0.0010736424,0.0105363885,0.083545424,0.0022846172,0.0075092413,-0.055473596,-0.09214718,0.018183006,0.0063369116,0.13183397,-0.019398049,0.017381659,-0.02198753,0.055496287,0.005638841,-0.030730726,-0.02855468,0.016234512,-0.043399602,0.09318292,0.03053999,0.036413115,0.0034723438,-0.07896341,0.063044995,0.030531527,-0.009796021,0.043427777,-0.039911762,0.017768733,-0.008113143,-0.09907216,0.03824811,0.014917619,0.090021476,-0.059590105,0.020382,-0.028197763,-0.014980754,-0.06307201,-0.03175168,0.036877476,0.03640438,-0.07709439,-0.033630546,-0.052054826,-0.04283404,0.05763547,-0.04304513,0.12358206,-0.10880178,0.08630108,0.04301638,0.014994669,-0.015466554,-0.034041427,0.011246616,0.027948659,-0.09455084,0.0005792491,-0.06296075,-0.03130272,0.0862346,0.020244041,-0.08540732,-0.049117595,0.0025981718,-0.029666545,0.03132802,0.01382349,0.015194694,-0.06392813,-0.014380485,-0.030388528,-0.07721332,0.041861992,0.03340817,0.042093452,0.071324475,0.007926948,-0.007784994,-0.028130556,-0.004165719,0.05616615,-0.028691817,0.0055489647,-0.028196104,-0.04404654,-0.08374003,0.012497134,0.16295452,0.024603877,-0.0012292125,0.060092013,0.0069671,-0.0045694364,-0.025862105,-0.103879966,-0.07532901,-0.021564612,0.045443784,0.012773471,-0.060338277,-0.008351296,-0.0061635124,-0.049950637,0.012859539,-0.07631614,-0.06661749,0.03525195,0.007942869,-0.045260668,-0.056860432,-0.026382344,-0.02006735,-0.058646392,0.04672821,0.045270413,-0.09314335,0.06916258,-0.021986503,-2.9681249e-33,0.09588724,0.027885493,0.014423418,0.05601958,-0.0326122,-0.03819509,-0.10307472,0.015856706,-0.018429043,-0.0642027,0.0014423811,0.11369299,0.030694978,0.0036743053,0.043547735,-0.04357238,-0.0107343765,0.015232545,0.046169885,-0.018404815,-0.048970502,0.05640483,-0.07016688,0.006946287,-0.04055854,-0.03573137,-0.052642934,-0.068926655,-0.0073189978,0.012018174,0.001329361,0.014021319,-0.002051319,0.07979549,-0.053730156,0.15720561,-0.11151269,-0.08208768,0.0604258,-0.095616184,0.0127136735,-0.007583208,-0.021290762,0.0330253,-0.015827755,0.027937058,-0.062439658,0.012515467,0.06396104,-0.007647284,0.03215144,-0.048191365,0.08379452,-0.006381043,-0.012543843,0.07529763,-0.033843685,-0.05768942,0.044218704,0.04216654,-0.037832238,0.02084026,-0.026121773,0.0074044196,0.0009498888,0.0125033185,-0.07451626,0.051286,-0.016926356,0.027354337,0.021992499,0.07373714,0.10004658,0.011308974,0.07451965,0.034153543,0.044338364,-0.044861216,0.052098457,0.102476515,0.049385894,-0.029176207,0.037230607,-0.057785686,-0.12029786,0.07918439,-0.0151756555,-0.0058265966,-0.013196824,0.01974516,-0.0060935305,-0.090408996,0.047027815,-0.05275595,-0.012606579,3.5381902e-34,0.025487091,-0.091721654,-0.047799602,0.017033871,0.005612462,0.04965119,-0.069632806,-0.059582856,0.009361043,0.034985438,0.09264941,-0.006275106,0.02137295,-0.07176524,-0.03741942,-0.0074422783,0.01438752,-0.0020383624,0.012350644,-0.041451596,0.0033692496,0.049345795,0.049025226,0.0713522,-0.015194985,0.010044068,0.002860665,-0.062486634,0.042820826,0.09955353,0.008942995,0.0050504967,-0.016586583,-0.01657414,0.03575962,0.048709832,-0.071976006,0.050760392,-0.019476783,-0.06447493,-0.019171579,-0.08693996,0.05332142,0.020141972,0.052143175,0.09792386,-0.036807183,-0.009006064,-0.073216334,-0.059089236,-0.052752018,0.045402836,-0.10989438,0.02069364,-0.02569996,0.13665557,0.0025809952,-0.072086066,0.030842338,-0.06254367,-0.0617762,-0.001080738,0.02400354,-0.06839538,-0.014365682,0.0008412612,-0.020911058,0.02236972,-0.010558789,-0.049291648,0.11166799,-0.001900482,0.020660799,0.02910062,0.0037336957,-0.10461033,0.019150762,-0.077255525,-0.055369593,-0.019571261,0.033689436,0.00011590402,0.026091738,-0.046897903,-0.018612647,-0.022569679,-0.015750492,0.034303375,-0.06599039,0.08188619,-0.0074605583,0.086282134,0.0027686588,0.032348435,0.027379053,-2.8407852e-08,0.0333828,0.005614466,0.08901551,-0.010172762,-0.03379918,0.061783522,0.028010039,0.02143837,0.049213324,-0.0134725645,-0.063609935,-0.0014239857,0.052092515,0.027558438,0.03476168,0.08088517,-0.0855082,-0.01879603,-0.01752922,-0.031812705,-0.08863847,0.007319967,0.0251559,0.009209703,-0.054563135,-0.02705487,0.018440869,0.049622726,-0.02701281,0.031928953,0.024286786,0.023305792,-0.02574708,0.061957575,-0.03074557,0.049010962,0.009619935,-0.037450988,-0.10382039,0.029119605,-0.046232868,-0.045390405,-0.013041968,0.056547187,-0.024999281,0.03143182,0.04034978,-0.0090320315,0.029759651,0.06599849,0.041214846,-0.049552467,0.028393285,-0.010422376,-0.13902967,0.014249818,0.032416523,-0.022403156,0.027017524,-0.058632046,-0.014697579,0.044270277,0.041122187,0.08782106 +2.1.1.27,Has some activity on phenylethylamine analogues.,384,1.0,-0.06377424,-0.09468905,-0.040093053,-0.037967656,-0.030428028,0.051053815,0.009999603,0.033243544,0.03848965,0.043394435,0.04996982,0.04585479,-0.046529714,0.087268434,0.07711846,0.0849571,-0.087347165,0.0515912,0.01834344,-0.01866973,0.009058102,0.06071257,0.091520764,0.03676678,-0.029296333,0.009417518,-0.0031965408,0.005212667,0.039222106,-0.022209488,0.07252764,-0.011227051,-0.035170987,-0.01138768,0.010607445,-0.0071849716,-0.12067768,-0.04645852,-0.002611043,0.063326254,0.050222915,-0.076359205,-0.057570785,-0.05144208,-0.02721275,-0.09416111,-0.061333165,-0.037632886,-0.010501461,0.052202933,0.013651701,-0.025919378,0.07059952,0.0010873693,0.018751353,0.0619864,-0.11254302,0.07774202,0.055480797,-0.012286321,0.07657339,0.03674535,0.007823063,-0.0012056818,-0.093675114,0.0048848046,-0.011063237,-0.0075447788,0.13476506,-0.07505404,-0.022409042,-0.058228973,0.012569734,0.051962707,-0.0064963745,0.026327781,-0.0033805138,-0.009553973,-0.04683757,-0.019538576,0.03285845,-0.032107357,0.019730082,0.094315775,0.09406249,0.042812213,0.025549907,0.07365139,0.0141150765,-0.084217094,0.060869016,-0.008556349,0.00056881516,0.014713526,-0.059851963,-0.009003685,-0.011649647,0.020648522,-0.0165943,0.052577086,0.02655505,0.020977547,-0.11164187,-0.054295458,-0.037812922,5.491277e-05,0.014244383,-0.07739415,-0.040981703,-0.062760346,0.02130081,-0.05512879,-0.0061620623,-0.0058772387,-0.021835975,-0.0021198508,0.054055523,-0.010359354,0.013446612,-0.040158506,0.002904064,-0.099810086,0.038830217,0.036340363,-0.0029461747,0.074741565,-0.11236744,-1.2057607e-34,0.045979206,0.034518212,0.047015294,-0.028011939,0.06769888,0.0132634975,-0.029442428,0.0042182263,0.093588926,-0.13646902,-0.022808427,0.0584648,0.02547328,0.05556598,-0.037084416,-0.037930503,-0.06983843,-0.020068679,0.07622109,-0.08384413,0.032859642,0.024496926,-0.0005997423,0.092446536,0.0038702562,-0.04690969,-0.08500056,0.055819646,0.05567653,-0.010615198,0.031559836,-0.101593345,-0.054742288,-0.025077356,-0.075053446,0.07276444,-0.11597091,-0.09355335,-0.025129,0.07006412,-0.065893084,-0.06223674,0.01963936,0.027847534,0.022234652,0.055595353,-0.093942,0.02944336,-0.025808113,0.010074669,0.018278569,-0.021097466,-0.044911362,-0.058087304,-0.06172409,-0.0026189277,-0.016596016,-0.07554289,0.06392052,0.04087666,-0.03764091,-0.0029143062,0.019429842,-0.06597119,-0.02612234,0.030039119,0.013360258,-0.06471052,-0.04650173,-0.04884557,-0.008890587,0.015620254,0.030271264,-0.007761662,0.08811199,-0.01625626,-0.028954802,-0.009198678,-0.024543239,0.030253643,0.06751763,-0.046998683,0.035685793,0.07624532,0.002994628,-0.06848428,-0.02259157,-0.10169329,0.07304954,0.030100165,0.013378318,-0.057311356,-0.016104184,-0.007988096,-0.030007565,-7.46508e-34,-0.002546485,-0.00491603,0.002774588,0.064519815,0.035614867,0.02016985,0.08844812,0.018685725,0.01985475,-0.0605267,0.11187881,0.012285721,-0.02426561,0.0051476285,0.016801717,0.043009967,0.021970585,0.050689887,0.027998647,0.06527159,-0.042348042,0.03677809,0.029942531,0.121964455,0.097596444,0.011414468,0.0016592008,-0.060575377,0.035176408,0.010820171,-0.03757714,0.010147427,-0.06386998,-0.078745715,0.018838326,0.046672333,0.037484057,-0.030465877,-0.021392994,-0.033884484,-0.019284092,-0.023407914,0.08098379,-0.013853196,-0.019098666,0.06769728,0.028734874,-0.009818979,-0.098246776,-0.049522664,0.021932533,0.07540054,-0.018779548,0.0024265598,0.05199786,0.039862342,-0.011032522,-0.038476095,-0.013292169,0.021811012,-0.02116949,-0.077282414,-0.015034893,-0.02246168,-0.0077330493,0.030134676,-0.01597586,0.0937674,0.012116407,-0.07689117,0.067863606,-0.01797691,0.09753066,0.063943304,-0.05214262,-0.04502876,-0.003059942,-0.0680798,7.692697e-05,-0.032432683,0.030709213,-0.024414588,-0.0368869,-0.0865662,-0.007419115,0.033307172,0.027200043,-0.0035845083,-0.04846516,0.041762345,-0.006685011,0.028903523,-0.04163725,0.091387086,0.103400536,-1.8893989e-08,0.051270816,-0.04282194,0.048987873,-0.07444212,0.042486385,-0.063833125,0.053135082,0.05302324,-0.06507395,-0.037150092,-0.0057815537,0.06020386,0.067570485,0.06264455,-0.017378489,0.032551784,-0.060348738,0.024595888,-0.055205014,-0.053283565,-0.08199432,0.060083255,-0.082140185,-0.01587106,0.02976005,-0.012514912,0.078584105,0.016114464,0.039135985,-0.08350903,0.026759084,0.0108703235,0.009716897,-0.0034703591,0.0052259513,0.014462399,0.07298814,-0.036293935,-0.056312453,0.033405386,-0.08792277,-0.046170983,0.016318409,0.024533506,0.051102187,-0.035228945,-0.0043493817,0.0218062,-0.043775074,-0.017553959,0.061204042,0.024578098,0.00083481095,-0.05023659,-0.096169084,-0.048903976,-0.03607646,-0.012135555,-0.04634992,-0.08842013,-0.04283572,-0.0062051867,0.17285742,0.033408836 +2.1.1.28,Acts on various phenylethanolamines; converts noradrenaline into adrenaline.,384,1.0,0.045214143,0.009714041,-0.05419404,0.068117246,0.034014862,0.05619339,0.076134816,-0.033291955,0.06102543,0.027278122,0.005381765,-0.023968978,-0.03961667,0.029406702,0.022884035,0.029307414,-0.06993627,0.0018487271,0.0073833982,0.020473085,0.036904007,0.013926551,0.014348118,-0.00547209,-0.0629032,0.07595822,0.035487518,0.0012504653,0.043715432,-0.004699169,0.059306167,-0.07379776,0.03846658,0.022767482,-0.05381175,0.060212996,-0.08261258,0.009781408,-0.013378395,0.1388166,0.06629523,-0.055211615,-0.07046216,-0.040141817,-0.0026635202,-0.037902385,-0.029882459,-0.01410218,0.0065140175,-0.024768962,-0.001357654,-0.031790383,-0.025660489,0.05348481,-0.04221198,0.06665221,-0.088610135,0.051083177,0.026494041,-0.011381463,-0.03835339,0.110505074,0.0067439717,0.028417414,0.044570785,-0.014386065,0.03975174,-0.0253714,0.07899604,-0.100924015,-0.020836296,-0.07450582,0.06892572,-0.056449313,-0.016817177,-0.00898008,-0.05703188,-0.025510581,-0.027480442,0.011967117,-0.0002084987,-0.022161221,-0.016439583,-0.011631568,0.07302164,0.02498927,-0.019955322,-0.03203573,-0.006757564,0.064513125,-0.040614557,-0.07434089,0.0073240586,0.032891143,0.03539249,-0.03062857,-0.034176208,-0.010267976,-0.025703311,0.049735818,0.019944957,0.08254328,-0.1216991,0.043594636,-0.10942088,-0.039581776,0.015166805,-0.06401524,-0.03723194,0.032385286,-0.0790311,-0.028160047,0.00015433354,0.015503975,0.029304137,0.10202929,-0.0930554,0.005646496,0.017875774,-0.03417793,0.051834468,-0.04033809,-0.003567878,0.05574083,-0.009598221,0.100201435,-0.045879643,2.2249985e-33,0.114645414,0.022729501,0.04668931,0.003505448,-0.021238204,0.03595928,-0.032531556,-0.0443339,0.12530723,-0.043872863,-0.048883386,0.0520209,0.06080317,0.10999647,-0.0068793306,-0.06268866,-0.09043709,0.055753224,0.14575787,-0.066326424,-0.0403077,0.057708994,-0.06528065,0.09706837,-0.055409644,0.05737282,-0.07803102,0.08994533,0.00853149,-0.017059267,0.009865281,-0.03495205,-0.025101148,0.0037135617,-0.08591108,0.053201545,-0.04574705,-0.024649544,0.020533824,0.04118349,0.019381022,-0.02814086,-0.007926014,0.042269688,0.0037404818,0.0019725747,-0.06192801,-0.006537657,0.018801145,0.0286767,0.030638788,-0.06855808,0.06834627,-0.012288681,-0.08134027,0.050892692,-0.033350587,-0.05409565,-0.023626989,0.011295409,0.027130391,0.056358237,0.080154866,-0.022846317,-0.01332467,0.047714654,-0.017894942,-0.084804714,-0.037040196,0.007814535,-0.09404038,0.05766706,0.08978362,-0.034633957,0.063989736,0.01277411,-0.08785695,0.046092346,-0.029508438,-0.083144486,-0.008781413,-0.115400314,0.0715413,0.08711357,0.06668068,-0.07244887,-0.0045698555,-0.083591424,-0.011986305,0.031352628,0.016174424,-0.09859702,-0.04895051,0.026786223,0.012518598,-3.621463e-33,0.028866358,-0.062576406,-0.05535371,-0.005851389,-0.011635706,0.026968086,0.0010259483,-0.012603946,-0.0436935,-0.013869928,-0.0014310788,0.017451229,0.0482575,-0.002334241,-0.021521388,-0.038030412,0.030802425,0.05630743,0.0044486923,-0.012000973,-0.0009754376,0.0069989446,0.014197532,0.064200364,0.13013126,-0.0059343916,0.06530802,-0.041147277,-0.0052231746,-0.009841617,-0.018479448,-0.017899277,-0.082701184,-0.013870121,-0.09392231,0.058086723,0.0065944092,-0.048914377,-0.09806582,-0.10240994,-0.033664964,0.008615722,0.09250229,0.031720668,-0.0067991097,0.042268816,0.045455344,-0.021861566,-0.05015596,-0.020870646,-0.0054435795,0.053471845,0.004598144,0.01777019,0.0006365259,-0.008564885,-0.029252997,-0.06166788,-0.008817828,-0.05957359,0.012461091,-0.021141231,-0.032852843,0.025233628,-0.0031049435,-0.0540364,-0.014903531,0.0651376,0.010109984,0.00045898388,0.15481229,0.030489363,0.036645927,0.08374171,-0.07254242,-0.045538917,0.03644885,-0.07210976,0.024881022,-0.10954803,-0.049387902,-0.026443506,0.018750353,-0.04061113,-0.056327626,0.020809032,0.04194957,0.07395634,-0.025045633,0.00809078,0.020497605,0.03849238,-0.024245314,-0.02608641,0.037495557,-2.4158842e-08,0.022201931,-0.022198753,0.02592764,-0.016187299,-0.028278496,-0.019669304,0.062830724,-0.010587589,-0.06450661,-0.15898877,0.02585108,0.039174058,0.12016311,0.0033300854,0.07044212,-0.012196934,-0.043812186,0.09159952,-0.031000752,-0.06449626,-0.092334874,-0.053010806,-0.056531794,-0.002988044,0.08010259,-0.03136223,0.07907207,0.05653385,0.010104101,0.0028358747,0.0029523417,-0.027208028,-0.0041489583,-0.04529011,0.03691242,0.060682546,0.09134791,-0.023141291,-0.0109841665,-0.032967404,-0.0919318,-0.06695706,-0.020474289,0.0018795193,0.037828837,-0.0068979147,0.013323413,0.014720531,0.08621137,-0.035475757,0.038670328,-0.0018054626,-0.0038871125,-0.01921401,-0.04331633,-0.050082352,-0.078240134,0.008616697,0.046832245,-0.020394465,0.031905882,0.057071507,0.060996883,0.01732996 +2.1.1.32,"In eukaryotic tRNAs, two N2-guanine methylations occur, at the N2-methylguanine at position 10 and the N2-methylguanine at position 29.",384,1.0,-0.02989165,-0.09145146,-0.08775681,-0.06876827,-0.04405844,-0.023433493,0.02939465,0.008795183,0.0003980534,-0.03148512,0.10589171,-0.030906923,-0.079345405,0.026127314,-0.010914453,0.051882103,-0.111794114,-0.0538043,0.050677523,-0.016001092,0.028097643,0.09310164,0.006254582,-0.004133634,-0.013073518,-0.020778328,0.024804244,-0.0032089963,0.103323884,-0.048149355,-0.05344829,0.031341396,-0.019959029,0.05324965,0.011963673,-0.0030531622,-0.081455916,-0.0052747442,0.043788116,0.0019156481,0.04839013,0.020484013,0.023198113,-0.0046899053,-0.024778102,0.04133851,0.046492133,-0.01167055,-0.055550855,-0.016874995,0.01884901,-0.07222267,-0.006831423,0.058894906,0.03639594,0.042730436,-0.057371613,-0.047165852,0.045372147,0.036461238,0.09564323,0.015814507,-0.025337484,-0.07859256,0.067444205,-0.010805756,0.10895838,-0.014049341,-0.012415506,0.034814022,0.015460386,0.028283866,-0.042696726,0.034063205,-0.114552945,0.09561106,0.06447408,-0.02478287,-0.020897856,-0.032067467,0.0024887333,0.025619697,0.07879457,-0.04463824,0.012585808,-0.053370178,-0.060494754,0.11085079,0.026139587,0.066493005,0.055407383,0.055937923,0.056476615,-0.023208862,-0.097957805,0.041058637,0.052434776,0.04959348,0.055073045,-0.012246272,0.031145822,0.027609296,-0.04562899,0.026542405,-0.00016169762,0.029056408,0.039325237,-0.04724906,-0.028580287,0.04007279,-0.04888796,0.102777824,0.02604185,-0.00223628,-0.03947504,-0.0047875494,0.04602375,0.04840069,0.04693225,-0.00032091496,-0.09268391,0.034544732,-0.01570808,-0.02411814,-0.056467645,0.015058308,-0.1128819,1.2519598e-33,0.024624024,0.005677851,0.005324124,0.007492438,0.082796,0.021306004,-0.061443843,-0.04771331,0.033797126,-0.04752694,-0.10132551,-0.041961204,0.04418386,0.018726772,-0.056709237,-0.0026574822,0.0066653374,-4.820684e-05,0.020601211,-0.074202776,-0.044872914,0.03341005,-0.029674536,-0.08689588,-0.032663584,-0.0058786413,0.028764093,-0.008127692,0.010885992,-0.036238357,-0.03207784,-0.11547974,-0.03283269,0.04100949,0.14556818,-0.0046191053,0.029838467,0.030892165,0.005291313,0.023888465,0.056725252,0.043883137,-0.022326505,0.01450641,-0.03622494,0.011214436,-0.034181993,0.022171834,0.015479186,-0.0016979225,-0.040346738,-0.04047348,-0.043904904,-0.0153875,-0.008988827,-0.030263202,0.005502487,-0.070306025,0.011590776,0.020816568,0.020671612,-0.06403505,0.021210374,-0.016620282,0.010699627,0.020977752,-0.14906324,-0.06334175,0.05353525,0.018218042,-0.03409352,-0.075523235,0.15664642,-0.04400529,0.023308046,-0.039238106,-0.07552941,-0.09261238,-0.016366264,0.06643735,-0.047973823,0.009842048,0.015835444,-0.03317398,-0.029549556,-0.0024378414,0.020110797,-0.06511139,0.021405544,0.06693987,-0.009211237,-0.03283505,0.005870872,-0.056191064,0.04807878,-2.3894364e-33,0.025105264,-0.0051154206,0.04562704,-0.06804094,-0.029874533,0.04643162,0.035479035,-0.04578846,-0.06706769,-0.07970541,0.1379039,0.07141193,-0.013501841,0.014868743,0.05344629,-0.03238393,0.032727387,0.09295103,0.0145681435,-0.04162368,-9.8896315e-05,-0.06593016,-0.06871363,0.07303399,-0.0055423942,0.000525133,0.06101222,0.020412399,0.019719914,0.06099424,-0.07691175,0.009690789,-0.033815615,0.0570127,0.03750714,-0.040021807,0.0027478943,-0.03550499,-0.045402884,-0.0028522208,0.020076541,0.041367915,-0.004525352,0.10692049,-0.050602347,0.0723995,-0.0075058118,-0.07296489,-0.08214285,-0.06562122,0.07830624,-0.00992106,-0.0115385,0.032882623,0.037751336,0.050158463,-0.015207264,-0.015330911,0.029331986,0.038832817,0.010688268,-0.027908923,-0.06640888,-0.1064063,0.013665232,0.005087072,-0.037824363,0.10055684,0.0323126,-0.011510806,-0.10418358,0.016877143,-0.00680524,-0.040933806,-0.109335825,-0.064134784,-0.038694005,-0.0701604,0.027864374,-0.10314432,0.020493826,0.0030321954,-0.03786448,-0.016991282,-0.0042249914,-0.037454125,0.048680324,0.10031765,-0.004272458,7.863564e-05,0.0004107608,-0.0026520104,-0.0470895,0.05761599,0.020223102,-2.8529504e-08,-0.048812304,-0.079514414,-0.00035577454,0.02450836,-0.00498089,0.115579404,-0.047348764,0.09100781,0.08672658,0.000821393,0.0180959,0.015051548,-0.018997815,0.082410745,-0.010852545,0.079862684,-0.07905938,0.022360336,0.023286346,-0.0015091868,-0.079490714,0.08124294,-0.062030118,0.015229751,-0.025480147,0.029761048,-0.013778179,0.13605261,0.033892017,-0.05203205,0.06531198,-0.037925716,0.023503143,-0.02944281,0.03286142,0.045237053,0.028456181,-0.077940345,-0.02457652,-0.014944983,0.054761074,0.04584654,-0.07220483,0.054194614,-0.001923948,-0.02002322,-0.027663277,0.10508231,-0.059281316,0.009144103,0.0570837,0.02916805,0.0202296,-0.0016567023,-0.048252538,-0.032052696,-0.03376577,-0.03668692,-0.10440761,0.09434968,0.041549936,-0.013522901,0.054885656,-0.06166186 +2.1.1.33,The enzyme specifically methylates guanine46 at N7 in tRNA. 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+2.1.1.34,The enzyme catalyses the methylation of guanosine18 in tRNA. 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+2.1.1.208,"Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2'-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA.",384,1.0,-0.0019475025,0.03439543,-0.18640141,-0.04654994,-0.0321005,0.044367645,-0.096850835,0.06446034,0.07846852,-0.054741316,0.004075398,-0.03250043,0.09047261,0.045589004,-0.04866626,-0.03956565,-0.06794374,0.016033921,0.09681906,-0.007929119,0.04762904,0.15811111,0.013626129,-0.01995016,0.012266976,0.02509238,-0.060394127,0.013821178,-0.018981168,-0.07636449,0.07985874,-0.023006823,0.025100607,0.01700765,0.061295312,0.007986515,-0.037931558,-0.033329256,0.10563297,0.065704405,-0.042082846,0.04018946,0.021056429,0.038465284,-0.054592144,0.010438614,0.008862297,0.06519769,0.010939293,0.00061479566,-0.040152673,-0.07144036,-0.027409611,0.031141236,0.12761278,0.072300054,-0.02283948,-0.0804641,-0.021513142,-0.051573772,0.0770372,-0.044960544,0.03493497,-0.062112257,-0.10955116,-0.013241115,0.045370296,-0.039238915,0.086165,-0.04200932,-0.0926614,-0.02582856,-0.023519954,0.0606909,-0.0387688,0.033952445,0.019409869,-0.02477705,-0.036297835,-0.055714786,-0.0033245701,-0.042974386,0.008600063,0.059123896,0.058167193,0.0011493094,0.087381735,0.04385555,0.03807838,0.080985144,0.081243835,0.0024745055,0.05071688,-0.020412084,-0.07270804,-0.014862639,-0.03820864,0.011312866,-0.027329095,-0.032695,-0.0008895105,0.028333664,0.004899842,-0.00022296692,0.009209157,-0.0053625526,0.058792222,0.056350343,-0.056230932,-0.043155704,0.06545427,0.039912723,-0.015272816,-0.019609895,-0.007912135,0.043171838,0.08870353,-0.042095326,-0.049545933,0.0073530735,-0.027783144,0.04154273,0.0381546,-0.010965984,-0.05323546,-0.010721595,-0.048004173,3.9631983e-33,-0.026109722,0.037700858,-0.039817963,0.0070854323,0.03918122,0.064125866,-0.06738023,-0.012725471,0.034288976,-0.09924706,-0.12928383,-0.10757458,0.038051005,0.040396817,0.017922988,-0.0069449353,-0.042982563,0.004010582,0.013567421,-0.029199949,0.040450018,0.0018457792,-0.01409606,-0.032581765,0.009838387,0.028007906,-0.012507717,-0.046504166,0.097843245,-0.030912764,-0.027107205,-0.03722636,-0.03756484,0.019797908,0.07839371,-0.010529404,-0.04005908,-0.043163173,0.078197844,0.07432513,-0.027824469,0.032671932,-0.004322516,-0.010607507,0.07292508,-0.037877515,-0.017170714,0.06481327,-0.038580526,0.027431939,0.044033915,-0.042786,0.02003469,-0.038670424,-0.099738404,-0.013746345,-0.0019847567,0.025128122,0.012668983,0.00336582,-0.009138317,-0.020873,0.046461396,0.0048488695,0.042911973,-0.012973545,-0.026397318,-0.09970202,0.0020475755,0.058197457,-0.021471867,-0.05608345,0.10347385,-0.047970746,0.019046305,-0.01438048,-0.12877983,-0.019352138,0.11140153,0.04737339,-0.1021939,0.050210208,-0.029981991,-0.08824577,0.024463711,0.0026653756,-0.0043966975,-0.09023146,0.06523488,0.057997007,-0.0012677743,-0.046253182,-0.072247386,-0.015912453,0.088468656,-4.4023582e-33,0.10090272,-0.037135765,0.05916757,-0.044291604,-0.07596768,0.058641307,-0.037378408,-0.03668907,-0.01561816,-0.077742174,0.09155513,0.008260918,-0.031001212,-0.08773399,0.027904162,-0.10255096,0.011776158,0.04579609,-0.02731138,0.01129126,0.013048874,0.029493267,-0.036604315,0.074781865,0.011301356,0.015832964,0.0100602945,0.012855134,0.09352572,0.009302506,0.017959,-0.0070204753,-0.04529322,-0.043961402,-0.035427794,0.11544045,-0.019397551,0.04497938,0.017901028,-0.022020796,0.029469505,0.05214171,-0.045529533,0.082638286,-0.033961352,0.083701886,-0.015183577,0.018186904,-0.011406647,-0.09666095,0.030210106,0.00014277095,0.0021905624,0.040087204,0.0044623935,-0.06360773,-0.00051032525,-0.013959539,0.029660065,-0.0009550036,-0.054155283,-0.012214061,-0.032878436,-0.0040115,0.023153743,0.020158049,-0.009995285,0.06920602,0.14660373,-0.050904274,0.025133317,0.002715129,0.008280999,-0.030838162,0.0025549838,-0.037647452,-0.055098195,-0.041468635,-0.0044463435,-0.08972156,-0.01000367,-0.017686004,-0.009912973,-0.041788712,0.019870356,-0.058116138,0.030823184,0.031867545,-0.01154178,0.080662355,-0.018301839,0.019006845,0.00023871283,0.010638156,0.009784516,-3.887631e-08,0.017573418,0.0023633498,0.05177945,-0.00971664,0.01658203,2.5820516e-05,-0.09030806,0.033003367,0.044115547,-0.0014564178,0.035968293,-0.03051642,-0.009274602,0.003336846,0.0027631877,0.07910684,-0.06895524,0.02248446,0.028958384,0.01881945,-0.093404114,0.017662147,-0.1011658,0.03770511,0.017454779,0.004649287,0.026357364,-0.012146589,0.02141767,-0.026054874,0.120582186,0.0071758796,0.007584544,0.04512547,-0.07050146,-0.03350745,0.053079087,-0.025643706,0.04746627,-0.028388273,0.020504268,-0.060153984,-0.09082668,-0.009179458,-0.07408688,0.00783107,-0.030809134,0.024770638,-0.056424372,-0.024132611,0.09275859,0.043741558,0.056081384,0.010586327,-0.070331626,0.0038995768,-0.0014632668,-0.088158846,-0.023151333,0.013378952,0.004357695,-0.093571216,0.17176774,-0.052567735 +2.1.1.35,"Unlike this enzyme, EC 2.1.1.74 (methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing)), uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54 [4]. ",384,1.0,0.006808774,0.021733837,-0.08466479,-0.03786163,0.09479053,-0.039796304,-0.030106738,0.008267246,0.01073474,-0.077180326,0.03128947,-0.04542504,-0.092436045,-0.0150869815,-0.044799544,0.005485572,-0.073377565,-0.028023,0.028818272,-0.040377103,0.041420005,0.040356252,-0.020842638,-0.024718883,0.01165775,0.024339484,0.01815387,0.014668272,0.068945624,-0.08907418,0.021525983,-0.017016292,0.032076374,-0.056378953,-0.036412187,0.07008425,-0.0234182,-0.063542016,-0.0343356,0.05298365,0.037177984,-0.052059006,0.05029419,0.024051446,-0.014844509,0.008292948,0.008494859,0.032624014,-0.016643897,0.05372589,0.01832088,-0.008181213,0.007276699,-0.027532423,0.06348799,0.0016119981,-0.022239393,6.970184e-07,-0.033282213,-0.02340677,0.0007871506,0.0038762086,0.013065648,-0.009366173,0.012127348,-0.040112253,0.06747324,-0.13378304,0.036286347,-0.07037934,-0.099624194,-0.07103304,0.025282774,0.06671256,-0.00853451,0.019660776,-0.007012963,-0.06882858,0.112128384,-0.020975552,0.0034610373,-0.023053547,-0.012481454,-0.026982443,0.022391949,0.009013676,0.019088043,-0.0004798877,0.004369068,0.03143485,0.09972815,-0.037065435,-0.006596746,-0.012540437,-0.06904344,0.08963333,0.045697305,0.1214702,-0.021938933,0.010203525,0.0018732268,0.08214963,-0.13285238,-0.06719173,-0.07036167,-0.04127774,0.010776912,0.093694456,-0.028110266,-0.008159659,0.015693016,-0.053168792,-0.009568641,-0.029738165,0.01564948,-0.020243386,0.0073327413,-0.10582753,0.015886094,-0.016431982,-0.042178046,0.019272977,0.022983814,0.07358209,-0.03811378,-0.060533803,-0.11095573,2.9631377e-34,0.037431847,0.06868879,0.008450263,-0.028905833,-0.028342722,0.00067334436,-0.10068907,0.026806133,-0.045838676,-0.08590913,-0.041612078,-0.04409291,0.035019424,-0.018598082,-0.014668846,-0.048226394,0.036024123,-0.018491047,0.073646486,-0.069809005,0.017767953,0.05787781,-0.017109504,-0.0060448702,0.023704566,0.049235437,0.0086815525,0.028884338,0.06039227,0.033693366,-0.023709957,-0.039777152,-0.08387297,-0.020804064,0.016146382,0.030836223,-0.06753616,0.022705698,-0.03777197,0.057034787,0.07226386,0.08510521,0.037803695,0.0045978315,0.072742686,-0.03828535,-0.054278087,0.141955,0.050609577,0.019310407,-0.03516313,-0.025030626,0.05956087,-0.05156375,-0.060937606,-0.02672487,-0.036095466,-0.0352588,0.024932388,0.047742505,-0.020951742,0.045894623,-0.03888861,0.06613867,-0.05701328,-0.015527394,-0.008082376,-0.05153605,-0.047502324,0.08276421,-0.032975614,0.031012362,0.16950427,0.010474318,0.05857846,-0.043986626,-0.029708693,-0.020459289,0.016790826,-0.0019704155,-0.07333526,-0.007480234,0.0054985983,-0.006195598,-0.0017879731,-0.0011138188,-0.0040497924,-0.024175609,0.029065311,0.095525645,0.037567485,-0.11429585,-0.04341227,-0.00694222,0.04446544,-1.7733583e-33,0.066104755,-0.048030164,0.0459429,-0.053375952,0.03177015,0.016930372,0.09325686,0.0032844704,0.019308789,-0.01743024,0.17057656,-0.0026367372,0.03953943,-0.058159713,0.10255064,-0.059900478,-0.03620307,0.01072343,0.060168285,0.057692625,0.04285752,0.019480152,-0.07145528,0.05560381,0.032704942,0.021300018,-0.03311674,0.004284565,0.09570543,-0.017480185,-0.08925169,-0.0038450796,-0.034974784,0.023822863,-0.09417395,0.055460043,-0.046133157,0.08754395,-0.02621147,0.025601424,-0.048005275,0.033043507,-0.054189224,0.05039885,-0.0023079969,0.086532354,-0.05945771,0.007176978,0.0016351434,-0.10757206,0.033942375,0.017136924,-0.063611016,0.037834197,0.00962265,0.048937224,-0.020537395,0.076021396,-0.009406467,0.0031476389,-0.048873574,-0.04404472,0.025103176,0.012821596,0.032094665,-0.010970997,-0.036055725,0.07934274,-0.0067282873,0.032300103,-0.0002135288,-0.009061998,0.024769444,-0.027986819,-0.007198402,-0.07011219,-0.044094432,0.002864434,-0.0068192245,0.0036142308,0.05392578,-0.006985688,-0.0137772085,-0.006213883,-0.003790656,-0.04239155,0.099502355,0.12880379,-0.044255894,0.05708476,-0.07461399,0.041093655,-0.08329449,-0.010434689,0.00560389,-3.8756834e-08,-0.038736936,-0.09305279,0.056491133,-0.045541685,0.02317535,0.09640997,-0.051077824,0.059612546,0.007927799,0.0046578404,0.0028964987,0.041410446,0.02455807,-0.012294901,0.0472699,0.008564338,-0.07222548,0.06772138,0.011945999,-0.007421763,-0.10140024,0.041039232,-0.10327787,-0.02335766,-0.005888887,0.025131267,0.04578622,0.049402863,-0.02493668,-0.0674442,0.033369675,0.028876072,0.017623266,0.01653313,-0.096653916,0.030383082,-0.019781552,-0.050689198,-0.048011385,0.06329097,0.020568613,-0.04187012,-0.07630322,0.035971753,0.04367615,-0.024732636,-0.0032187183,0.042185444,-0.051686056,-0.00508711,0.047646873,-0.046271324,-0.015242974,-0.09084341,0.009641217,-0.022735847,-0.07152367,-0.1291835,0.0042238045,-0.031084951,0.13424106,0.012444687,0.14667265,-0.0005084443 +2.1.1.36,The enzymes from different sources are specific for different adenine residues in tRNA.,384,1.0,-0.021369766,-0.060426954,-0.05716725,-0.107508786,-0.0051555424,-0.05379698,0.012756532,0.0023073088,0.040615384,0.01907612,0.062118508,-0.017730083,-0.066948645,0.032959197,-0.06592928,0.016924316,-0.11649675,-0.037258334,0.02554455,-0.079909936,0.04014139,0.13431506,-0.049496073,0.027947145,-0.004229951,-0.025380969,0.04273243,-0.005432287,0.030561421,-0.044015545,-0.08976711,-0.03222085,0.023371771,0.0036631767,0.025199581,0.086668104,-0.14830787,-0.0035482857,0.057349686,0.037825443,0.09952605,0.022323258,-0.018098135,0.006472578,-0.070198655,-0.04986832,0.030632822,0.0616137,0.009006704,0.08973185,0.030680886,-0.06806852,-0.062974475,-0.0024738186,0.034532033,0.052576378,-0.07961545,0.005869758,0.011181223,0.03362289,-0.0070761032,-0.024661338,0.0010818865,-0.03989418,0.14168474,-0.07260204,0.06521992,-0.03482028,0.009861195,-0.0650229,-0.03952235,-0.04512047,0.006928996,0.03578795,-0.04858024,0.02505665,-0.0070981374,-0.007906021,-0.06713945,-0.0020064956,-0.0070744767,-0.008958407,0.047436297,0.001516649,0.042543527,0.022100434,-0.04218872,0.024344765,0.020816341,0.049821954,0.07274137,0.017633168,0.039627187,-0.04058023,-0.005852854,0.012177944,0.06468768,0.051479872,0.057557665,-0.06746188,-0.028074168,0.02360871,-0.024364382,-0.0067993943,-0.04445424,-0.019277228,-0.011870142,0.005289173,-0.027055973,0.032339897,-0.022903629,0.08261996,0.091010906,0.004269298,0.058063064,0.043605365,-0.0069007217,-0.03729422,0.041960027,0.011058535,-0.103347436,0.010399612,0.08171341,0.06517524,-0.01854184,0.056211904,-0.06909597,-1.4261233e-33,0.048939396,-0.009168475,0.032965284,-0.025063636,0.05470126,-0.025522871,-0.030466774,0.0364944,-0.0242935,0.011751554,-0.0805938,-0.021960203,0.030668518,-0.12219297,0.0010811936,0.025840035,-0.06823098,0.016889233,0.014626537,-0.00791333,-0.02832234,0.004858043,-0.015268884,0.018687746,0.026360102,0.0005580093,-0.03558651,0.055076905,0.0650807,-0.030498972,0.01583384,-0.05098456,-0.061006144,0.010623908,0.047850117,-0.053221397,-0.0052200076,0.015160255,-0.08966006,0.09602397,0.021449959,-0.014664971,0.047275916,-0.055736843,-8.49317e-05,-0.03110449,-0.02363035,0.059603248,-0.031127976,0.0683329,0.03340733,-0.04244391,0.06257878,-0.06639062,-0.052322667,-0.005122501,-0.041458827,-0.02728331,0.0716789,0.08799168,0.03282802,0.0627562,-0.016235827,0.043675996,-0.044657744,0.038422674,-0.10611795,-0.07523333,0.01702451,0.13189778,-0.041245624,-0.019705903,0.099879056,-0.020720407,0.039050084,0.0029853575,-0.102886595,0.025948977,-0.06713522,0.041528832,-0.04764467,-0.0068898303,0.008926746,-0.026529007,-0.04413371,-0.029928125,0.045844436,-0.061078873,-0.02141003,0.03316199,0.039234784,0.02256206,-0.122217976,-0.04906246,0.058466487,-6.1350497e-34,0.09369399,-0.09904064,0.03745598,-0.042700447,-0.052189343,0.06741994,0.010155636,-0.11000014,0.029920489,-0.034956824,0.06979001,0.06272117,-0.049262032,-0.05808622,0.04921079,-0.06783993,-0.040768497,0.029799456,-0.012876534,-0.005618471,0.02195844,-0.008235767,-0.029334499,0.024642467,0.020212557,-0.04091755,-0.013077246,0.08405155,0.026059935,0.023115773,-0.070330136,0.025955828,-0.013824187,0.07055297,-0.064059354,-0.00011009832,-0.038054947,-0.008931673,0.054790888,0.027217655,0.043413337,0.011301847,0.0085275825,0.07603454,-0.06305768,0.08023114,0.01244836,-0.0033282533,-0.06044854,-0.082785025,0.10712407,-0.0021840734,0.035950016,-0.0111770695,0.059354804,0.09555305,-0.004751349,0.011278536,0.034574475,-0.0133416215,0.024798268,-0.057144195,-0.05551219,-0.022041019,-0.003406594,-0.024960356,-0.016713612,0.016195731,0.012557896,0.042487778,-0.007672336,-0.029476693,0.02991654,0.03237425,-0.039183576,0.004297196,-0.004483037,-0.024800504,0.03374649,-0.070754,-0.06633066,0.038869835,0.0010474597,-0.027444707,0.051796366,0.061381154,-0.0013553122,0.1106621,0.01209139,0.06457522,-0.004858519,-0.015891666,-0.00655484,0.0068645016,0.011362962,-1.9103664e-08,0.020424213,-0.067467704,-0.023953546,-0.027969852,0.031144539,0.09331205,-0.037896458,0.07087461,0.07685183,0.02047352,-0.041799065,0.0086485315,-0.04510719,0.06743422,0.047858715,0.055596463,-0.10997585,-0.038002778,-0.017783709,-0.087662354,-0.12784775,0.05260427,-0.12376913,0.046874963,0.021624394,0.027843604,-0.016714249,0.11888464,-0.05101088,-0.00424427,0.022573965,-0.07587633,-0.010758125,-0.08422901,-0.034766197,-0.000320151,0.026209217,-0.034267403,-0.038743645,0.050448563,0.020661091,-0.08185788,-0.074402615,-0.024331223,-0.050741866,0.059740357,-0.009987179,0.06582376,0.010206781,0.042958595,0.038355015,-0.0033994108,0.031180998,0.011265983,-0.020133343,-0.025915861,0.023567189,-0.1454391,-0.04351668,-0.015420391,0.04371737,0.03663594,0.15274906,-0.055302616 +2.1.1.38,Puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3'-hydroxy group with an amino group and acylating this with 4-O-methyltyrosine.,384,0.99999994,-0.075017,-0.019771922,-0.11590739,-0.06987061,-0.06724055,0.038319975,-0.046958636,0.080120675,0.010224288,-0.06326761,0.02125797,-0.016065413,0.014575647,0.015604029,-0.043526817,0.049270637,-0.06272676,0.032812253,0.07993917,-0.031955402,-0.054486632,0.07803246,-0.020541692,0.026277024,0.00571611,0.040403605,-0.0465018,0.0052320035,0.06789029,-0.039386533,0.042804293,0.03915727,0.08690824,-0.030613849,0.051576048,0.016022598,-0.023377739,0.03586939,0.05609762,0.041236978,-0.049634367,0.030841678,-0.0021172476,0.00017362552,-0.027954128,-0.01818643,0.015093166,0.079690956,0.07369714,0.005520144,0.042082574,0.011907065,-0.0025776033,0.009428931,0.047703706,0.013280379,-0.09684769,-0.058570113,-0.012002438,-0.003876168,0.068607576,0.013293199,0.024330705,0.021524848,-0.10286319,0.009892256,0.039461274,-0.049045395,0.051771063,0.022596851,-0.03632096,-0.050376937,0.04668107,0.0026882468,-0.034840915,-0.03186879,0.040434305,-0.06948276,-0.013350686,-0.026238618,0.02506395,0.02975677,0.03479535,0.08970669,0.044062633,-0.013480532,0.053282455,0.009628071,0.014682114,0.017715042,0.033306696,-0.0017798647,0.003317071,-0.071126975,-0.077992074,0.042288803,-0.066669814,0.019631045,0.08410846,0.01732975,0.027883545,0.010560018,-0.065674946,-0.065474585,0.05178153,0.012061521,0.05027806,0.08143246,0.005250966,0.0073205708,-0.07218816,0.013996017,-0.08795619,-0.0065849572,-0.056422807,0.033794813,0.067427956,-0.060922995,0.0010084565,0.015501474,0.001956453,0.08310242,-0.057525486,0.0019418553,-0.011526362,0.004958807,0.03177067,-1.2432676e-34,-0.07518197,0.10024276,0.03491362,-0.035141528,0.061782554,-0.020772016,-0.053652816,-0.053842075,0.028412497,-0.006569282,-0.03872218,-0.033939235,-0.01960777,0.06785616,0.02559313,-0.06208685,-0.06100066,0.0711694,0.046948865,-0.014006032,0.046745755,0.07159132,-0.0044487873,0.008943165,-0.020352555,0.060629375,-0.015138573,0.05737061,0.06647883,-0.028695269,-0.08400897,-0.0077983737,0.0024200378,-0.06071179,0.020624729,-0.07486448,-0.07428185,-0.05025522,0.06405922,0.09880567,-0.007181171,-0.008347405,-0.0637963,0.006823563,0.040568814,-0.01681238,-0.07725222,0.030363442,-0.0061887424,-0.032307036,0.039207302,-0.054767404,0.018263003,-0.059935752,-0.01658411,-0.026875135,0.0075404737,0.07824483,0.042789016,-0.014182136,0.0033314966,-0.019417955,0.023765462,-0.05966287,0.036974106,-0.090402886,-0.011239552,0.00053517654,-0.021242125,-0.04279552,-0.048496243,-0.027974626,0.02876587,0.06423873,0.12215147,-0.027256778,-0.07962022,0.01618229,0.08320625,-0.03051089,-0.08106866,0.018955493,0.041239478,-0.07381631,-0.045685165,0.0077659823,-0.018762322,0.0147814425,0.046106048,-0.0019447126,-0.028600197,-0.0882353,-0.02956834,0.042999223,0.0389105,-2.7114557e-33,-0.020316448,-0.0069836755,0.07930723,-0.049799748,-0.020936884,0.09364189,-0.01936403,0.025170937,0.028579151,0.024872998,0.05269442,-0.025534919,-0.06174542,-0.06556566,0.050551295,0.06112531,0.033879668,0.03600988,-0.100305736,-0.003533501,-0.015494813,-0.04288211,-0.048938878,0.098104104,0.03659531,0.060060956,0.032966986,-0.050315917,0.10196317,0.091313146,-0.04847957,-0.07037174,-0.021957124,-0.0003166339,0.005748122,0.10601999,0.02794974,0.030482307,-0.07821605,-0.06783732,0.009919662,0.008152017,-0.010100865,0.06707296,-0.01746444,0.05898175,-0.04989277,0.015285792,-0.024051007,-0.04835636,0.026848365,0.01969223,0.08450427,0.006568268,0.0015912534,-0.039000753,-0.00094486534,-0.07093434,0.05278298,-0.030021785,-0.027441792,-0.086024046,-0.039308533,-0.009524296,-0.0036959134,-0.0066657206,-0.07885754,0.066519246,-0.01218723,-0.0705062,-0.043803524,0.036187682,-0.044749487,-0.020067113,-0.013749713,-0.007552495,0.008714959,-0.15292361,0.0031382595,-0.0149321165,-0.0086621,-0.048942793,-0.06424241,0.050366845,-0.053819433,-0.050564367,0.105444156,0.030742293,-0.002062642,0.0045148446,0.0013880936,0.06856561,-0.08733233,0.010781004,0.019288745,-3.5071533e-08,0.13403775,-0.085788436,0.023198105,-0.04014921,-0.01991506,-0.030056404,-0.14378487,0.017551033,0.044830203,-0.027590623,-0.009569652,0.056192588,0.0695841,-0.02209519,-0.035977945,0.04282894,-0.013224978,-0.030923566,0.040282194,-0.019915551,-0.112818934,0.03750619,-0.056511328,0.0021894746,0.06590081,0.03668938,0.04375975,-0.008868719,-0.01677998,-0.007856572,0.0757464,0.012773665,-0.11014331,0.019057682,0.04841582,0.058001895,0.040709596,-0.094551235,-0.009718827,-0.0021898558,0.046746273,0.03560467,-0.067381285,0.012243497,-0.04850091,0.032182578,-0.04420153,0.018108081,-0.06858576,0.002443092,0.029218718,-0.002031848,-0.019627716,-0.0865441,-0.11475775,-0.0037895783,-0.006319818,-0.11231449,0.0039369958,-0.05730644,-0.05590879,-0.01234023,0.2325418,-0.0013840621 +2.1.1.41,"Requires glutathione. Acts on a range of sterols with a 24(25)-double bond in the sidechain. While zymosterol is the preferred substrate it also acts on desmosterol, 5alpha-cholesta-7,24-dien-3beta-ol, 5alpha-cholesta-5,7,24-trien-3beta-ol, 4alpha-methylzymosterol and others. S-Adenosyl-L-methionine attacks the Si-face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond.",384,1.0,-0.052283365,-0.0069796764,-0.018265989,0.008875602,-0.019079743,0.004157464,-0.0611661,0.07796236,0.006811027,-0.026705863,0.035926636,-0.010137262,-0.05322208,0.004436629,0.011421103,-0.009615546,-0.013946188,0.035003666,0.013322152,-0.0156054245,0.03431976,-0.077639505,-0.014944665,-0.039238904,-0.004979436,0.017959045,-0.037552945,0.08294809,-0.0035471441,-0.10203187,-0.011751031,-0.08024763,0.017611157,-0.022621127,-0.06577746,0.045629244,-0.068833545,0.0013965942,0.064138345,0.0149010625,0.046350148,-0.05914593,0.014089228,-0.020089593,0.0028632665,-0.0708189,-0.07745163,0.03995781,-0.039020695,0.029794164,-0.009170886,-0.100469366,0.013077823,0.08025626,-0.0012925677,0.07251125,-0.0759869,0.03161262,0.009129903,-0.015350681,0.049668938,-0.017444458,-0.046943955,-0.06778138,-0.09845905,-0.038120218,0.00782795,-0.038250636,0.019577377,0.077253856,0.019232048,0.0002979546,-0.023839407,-0.038536955,-0.035765454,-0.031586178,-0.0437516,-0.108119875,0.037265502,-0.033654336,0.06711625,0.029350063,0.017081585,0.07952145,0.10814056,0.026385752,-0.042137086,0.010861914,-0.02281326,0.0021339674,0.011539931,0.01630383,-0.026217295,0.00022345522,-0.05772299,0.0028942607,0.016836016,0.039352015,-0.08021933,0.008391541,0.08024869,0.041360255,-0.08530706,-0.021595052,-0.017896095,0.010447314,0.03865403,-0.005418032,-0.07122274,-0.015155023,-0.013359023,0.0131989615,0.036443606,-0.055721518,-0.062340777,0.084746756,0.012289256,-0.00015370054,-0.04253994,-0.04705173,-0.008601909,-0.00960682,0.0013986499,-0.0072228964,0.013291812,0.058527436,-0.021924162,2.3083943e-33,0.05952314,0.057937175,0.016365174,0.06923097,-0.025476787,0.0342455,-0.016832273,0.02159881,-0.030982578,-0.06529127,-0.04451154,-0.07792743,0.012523757,0.044086024,-0.07401643,0.05235284,0.032367393,0.029623542,0.022657603,-0.06899331,-0.007916536,0.04615031,-0.07775791,-0.05076629,0.025452217,-0.024922354,-0.014378344,-0.0036361588,0.022334702,0.03770384,-0.050342787,0.029069632,-0.02484635,0.045628566,0.112486176,0.06745794,-0.09539419,-0.034344457,-0.018013397,-0.025613204,0.05302364,0.042771,-0.047728974,-0.01961396,0.06435541,0.029992403,-0.05892141,0.047971483,0.041880492,0.0380446,0.03834075,-0.029443035,-0.03154231,0.11108901,-0.09403259,0.03802361,-0.046541944,-0.06635694,-0.020579014,0.11729334,-0.010983862,0.048206598,0.0021340456,0.033789814,0.009383748,0.07114076,-0.10453399,-0.0540873,-0.100433156,0.080738835,0.032355893,-0.019172182,0.01943406,0.05661298,-0.04068124,0.03749881,0.014060829,0.019623946,0.02591553,0.0014702776,0.020925023,-0.043602936,-0.021458143,-0.05932133,-0.102910586,0.013359435,-0.006493433,-0.05580171,0.054587144,0.06586725,0.009170996,-0.15282923,-0.011577762,0.015651457,-0.062458746,-3.4090493e-33,0.021497428,-0.03110878,0.051372603,-0.055706035,-0.025657412,0.017674452,-0.009248511,-0.098097995,0.066637084,0.026927624,0.10043983,0.030776305,-0.056774523,0.002996083,0.02712587,-0.011158334,-0.020542445,-0.0015010863,0.012108325,-0.044411704,-0.008290125,0.065515004,0.044986963,0.20126313,0.077677585,0.027948929,0.058706876,-0.033390053,0.10320679,0.07705983,0.019553535,-0.056941375,0.02705403,-0.02517193,0.00188169,0.06368161,-0.047207683,0.010074624,-0.004042741,-0.026524024,-0.037791368,-0.026019998,0.053476017,0.08523268,0.052445702,0.026473317,-0.07625727,0.01655801,-0.024800077,-0.05062813,0.010358842,-0.09400156,-0.044695184,0.011674668,0.03767417,0.060185634,0.019255605,0.009015824,0.0047255987,-0.058010098,0.045416027,-0.0010410832,-0.050841875,-0.08885816,0.026794039,-8.3470695e-05,0.060203213,-0.026787043,0.042517263,-0.03298111,0.01635725,0.035738654,0.046273768,0.015631692,-0.11024671,-0.022640567,-0.016494432,-0.020045452,-0.018765997,-0.021358725,-0.04348051,-0.04692543,0.04441871,-0.012625155,-0.009999659,-0.023825282,0.024159068,0.08584552,0.01084145,0.037427075,-0.062061336,0.043497883,-0.02541557,0.032726716,0.008786925,-5.2920342e-08,0.09557389,-0.092770666,-0.0058080317,-0.055192575,-0.1519127,0.00341745,0.030802857,-0.057244975,0.0772717,-0.009931502,-0.026564004,0.15668057,0.062031113,-0.0061908136,-0.019563682,0.019844316,-0.04654399,0.0145592075,-0.036922995,-0.05576806,-0.105952345,-0.018149922,-0.016725956,-0.004179297,0.01930718,-0.048198767,0.08249706,0.13827027,0.0093590645,0.003195465,0.11200001,-0.07297271,0.04266758,0.11246407,0.049167786,0.086280175,-0.01717812,-0.04908657,-0.0041568675,0.02686611,-0.005278809,-0.0023749396,0.02072518,0.07161768,-0.029936226,-0.06070998,0.0027808296,0.06124445,-0.0036497908,0.074520215,-0.075134456,-0.024245644,-0.012144286,0.0023639998,-0.045546107,0.012979419,-0.012039398,-0.021247398,0.03991851,-0.03119633,0.06696865,-0.0076426947,0.1394074,0.09129683 +2.1.1.42,"The enzyme prefers flavones with vicinal 3',4'-dihydroxyl groups. ",384,0.99999994,0.004606047,-0.11635621,-0.0779882,0.01637012,0.030489763,0.02466638,-0.07512991,0.04319094,0.056353327,-0.070051864,-0.027712392,0.007504982,-0.122958526,-0.0064831697,-0.032128487,0.038748447,0.009927594,0.042442013,-0.022989158,0.022645716,0.045962207,-0.09945088,0.08929608,0.03769119,-0.004567756,0.02874349,-0.010817543,0.05170389,0.010229925,-0.0854289,0.035794843,0.044431802,0.027794667,-0.010497799,-0.094417095,0.017640278,-0.03304468,-0.031459488,0.028399035,0.027531946,0.061270904,0.04055713,0.03263776,0.02371415,0.04091588,-0.091366895,-0.060347416,0.016833307,0.08396421,0.056796804,-0.037637565,-0.042829897,-0.06170985,0.07685795,-0.009290074,0.008460207,-0.08384322,0.03742964,-0.024513422,0.05281578,0.046105344,0.029382441,-0.0043460554,-0.032052547,-0.0465799,-0.013648117,-0.053567354,-0.0022848933,0.00890241,0.017450795,-0.01822869,-0.063921936,0.016892467,0.08260628,-0.0056241807,0.06293028,0.03684961,0.022268686,0.02065492,-0.029946238,0.019305749,0.0009368568,0.014103996,0.14465144,0.014904169,-0.0028551803,-0.06447595,-0.012726333,0.05251291,0.061197318,0.05587332,0.059729405,-0.053407375,0.054423608,0.018359382,0.049556714,0.06129537,0.009664341,-0.04396168,-0.011612897,0.04581911,-0.052381244,0.014073184,-0.0510625,-0.06462438,0.013842966,-0.010298926,-0.018332973,-0.015092108,-0.05727748,0.040469017,0.025146538,0.0024498305,-0.081929184,-0.07576649,0.05370743,-0.033898238,-0.091292225,0.0016698864,-0.044635147,-0.05740324,0.052136756,0.0928739,0.020004293,-0.02654099,0.012693412,-0.06854038,-1.3643861e-34,0.02693037,0.02263377,-0.010544776,0.017059471,0.045578692,0.0066784904,0.004562397,0.082160555,-0.05081074,-0.020124678,-0.14644507,0.0035431222,-0.03729985,-0.0139235975,0.048202775,0.0057570427,0.034518544,-0.08955681,0.0020730025,-0.060516782,0.03907128,-0.012944265,-0.06682893,0.097922534,-0.018922886,-0.016619207,-0.017211823,0.020142706,0.07350274,0.019557403,-0.053314667,-0.07313733,0.016942132,-0.0077582444,-0.024193017,0.08242249,-0.09036541,-0.058917236,-0.061433397,0.1024907,0.01787277,0.016136035,0.03854387,0.017029736,0.014503924,-0.022193654,-0.031741485,0.04916288,0.053010922,0.06323227,0.09289103,-0.030041588,0.0765258,0.064790666,-0.025109816,0.039884295,-0.06978997,0.047377292,0.037742067,0.020721173,-0.009668702,-0.00010962491,0.009960319,0.041988138,-0.04976522,0.056351695,-0.013528693,-0.013756819,-0.005471028,0.09829256,-0.008687566,-0.044608884,0.033292513,-0.012522971,0.096331224,-0.01917027,-0.044137586,-0.0058284397,0.09913683,-0.0068775723,-0.006347889,-0.033617508,0.006336567,0.07493736,-0.09913777,0.013264396,-0.018184077,0.022849035,0.053687092,0.045811385,0.030028127,-0.05310241,0.055641424,0.01564233,-0.04471815,-2.6809904e-34,0.044918317,-0.08339122,0.07225299,-0.0029990547,-0.04608119,0.10478448,0.013731045,-0.10437571,0.039126076,0.02600447,0.06863589,-0.07211317,0.006694883,-0.06742445,-0.021594232,0.09114004,-0.050136004,0.036254663,-0.037497178,-0.043581463,-0.010998841,0.07810205,0.0038136316,0.048361003,0.0046769567,-0.04621898,0.061410274,-0.024290832,0.020041093,0.058928877,-0.02742101,-0.01533752,-0.06452354,-0.017364329,0.0069258185,0.08152954,-0.056699876,-0.02200197,-0.040904075,0.09731314,-0.061986584,0.031330466,0.0014743245,0.08442896,0.027014598,0.063337065,-0.074247256,0.014027755,0.043475997,0.0145049235,0.0377038,0.010752576,-0.031968966,0.073622614,0.023470834,0.0010183308,-0.0061261673,-0.0044726925,-0.013806244,0.006593716,-0.03750177,-0.13383639,0.036102626,-0.045713216,0.03780149,0.057879943,-0.041805793,0.092838824,-0.0015537874,0.012776674,0.05104323,-0.07089988,-0.018331133,0.08962166,-0.014416075,-0.016844107,0.00020376379,0.0054750904,-0.021070207,-0.0070035304,0.05470974,-0.021441994,0.049393844,-0.026076648,-0.082676955,-0.012707414,0.020193039,0.09276028,0.020430977,0.07845899,0.005858933,-0.024027258,-0.05983505,-0.040579632,0.05035557,-2.5124596e-08,0.018002596,-0.049208835,0.025565289,0.038084403,0.014523419,0.045388114,-0.060767513,0.016257154,-0.032410137,0.029664874,-0.06696569,0.07211408,-0.04418282,0.047525063,0.0049189394,-0.014548125,0.0074459426,0.03712697,-0.015999567,0.0002840941,-0.098862775,0.037896235,-0.112581715,-0.027124714,0.017512675,-0.07269834,-0.081478305,0.027733373,0.054971617,0.018476892,0.07224996,0.034890197,-0.013476161,-0.0674369,-0.17093469,0.0070739524,-0.04895795,-0.021176387,-0.054420464,0.020072667,-0.029250233,-0.071522065,0.008094451,-0.005337872,-0.04259926,-0.047412746,0.04701572,0.0040053907,-0.026346702,0.010925906,0.027173119,0.004546445,-0.015102597,-0.012112192,-0.0502787,-0.061659172,-0.008670782,-0.04036348,-0.06008135,-0.18705417,-0.051016584,0.0029073113,0.17424092,-0.007991839 +2.1.1.233,"Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes. 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+2.1.1.43,"One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase.",384,1.0,-0.030899953,-0.0041216887,-0.11008053,-0.0032489677,0.053170074,0.06050702,-0.0396596,0.04746061,0.013861696,-0.08722742,0.0701974,-0.07561772,-0.025810309,-0.020826805,0.037191305,0.07391123,-0.122807264,-0.04546503,0.0028796182,-0.034257144,0.015831681,0.07100755,-0.019707747,0.01082233,-0.026718967,-0.011367601,-0.030941097,0.025262441,0.077368334,-0.034518853,0.0018494327,-0.020273943,0.0030406206,-0.007768842,0.074668385,0.017914616,0.0011431378,-0.060187418,0.008709724,-0.0064712428,0.06387367,0.059474625,-0.032848746,-0.03302336,-0.037586335,0.0030170118,0.042178858,-0.000332623,-0.013368991,-0.04655896,0.037416823,-0.0900775,-0.0089813,0.03017194,-0.004780758,-0.008241861,-0.10551841,-0.032231174,0.040626034,0.054913618,-0.022622991,0.06262912,0.05201162,-0.022045681,0.062184714,-0.024852002,0.015240602,-0.06415294,0.035185203,-0.07556784,-0.08133267,-0.14360046,-0.016703928,0.04856019,-0.016043484,-0.0098835,-0.016743956,0.017255358,0.018059334,-0.049203485,-0.01584726,-0.03253476,-0.024376824,0.029292924,0.025637824,-0.08604888,-0.03439122,0.086050086,0.010303515,0.003322412,0.042896282,-0.036218874,0.07288801,0.021579819,-0.035871405,0.031717766,0.025613992,0.1104201,0.0215861,-0.015657365,0.008576527,0.09222378,-0.06275931,-0.021236926,-0.0016021653,-0.00043747848,0.04472207,0.081592076,-0.014372978,-0.0591333,-0.029177925,-0.0028861228,0.01872237,-0.022689551,0.005643796,0.027583933,-0.017378218,-0.028611777,0.07763512,-0.03976177,0.04350538,-0.007776717,0.072494015,0.035951637,-6.4545886e-05,0.051042255,-0.15707672,1.7570477e-34,0.057828534,0.0014810377,0.044035453,-0.023099909,-0.02725167,-0.0003869613,-0.054767407,0.039174102,0.042048283,-0.063754484,-0.06159732,-0.058512606,0.07675852,0.059453513,-0.054496802,-0.049971532,0.0055612586,-0.038341664,0.023036612,-0.0086578075,-0.06602234,0.05933307,0.007296011,-0.025432488,-0.003390851,0.029732525,-0.0075469087,-0.0067414916,0.045065477,0.0032564464,-0.052147772,-0.1392895,-0.06759524,0.019164609,0.059516262,0.037197202,0.027570076,0.01507342,0.017638754,0.030672092,-0.024354031,0.013312877,-0.00020604287,-0.07643635,0.02303556,0.015643016,-0.10909173,0.044314075,0.0036999856,0.01344152,0.0165281,-0.066974476,0.055522554,-0.0637617,-0.05641289,0.0046260743,-0.008199368,0.013676287,-0.083453104,0.079731144,-0.037344895,0.04037873,-0.031488463,-0.00045869066,0.028206589,-0.002575084,-0.07400732,-0.05168321,-0.027210314,0.031599995,-0.08383896,-0.011390091,0.15810761,-0.041695833,0.06279239,-0.080400966,-0.10631061,0.016836783,-0.031254247,0.08510674,-0.034204375,0.011986061,-0.033475332,-0.045348104,-0.028545933,-0.05578098,0.025706109,-0.047423806,-0.0028599943,0.0317871,-0.06221055,-0.049412124,0.0057241824,0.058597617,-0.060862478,-2.9298264e-33,0.015882447,-0.031016743,0.011722449,-0.05239437,0.006901896,0.041221756,0.05927288,-0.023532135,-0.020303993,-0.009618502,0.1399356,-0.017134342,0.028585946,-0.049907397,0.08361624,0.024009118,-0.0636684,0.09905966,0.037344866,0.025753235,-0.012471205,-0.044578064,-0.04275751,0.09513122,0.033383925,0.047721718,-0.040602952,0.048854247,0.113769226,0.049432635,-0.10053106,0.03294217,-0.024058264,-0.05760963,0.041189775,0.033320405,-0.0140605215,-0.062456597,-0.024770528,-0.020711603,0.036925234,0.06690227,-0.0008906775,0.098441035,0.04152737,0.10377011,-0.014372053,-0.011173112,-0.100496516,-0.0367116,0.017921977,-0.029712426,0.03328654,0.09085774,-0.012028863,0.045719493,-0.0015917476,0.09541224,-0.0107711125,0.052978095,-0.0045282207,-0.070713975,-0.057833612,0.025612928,0.020881224,-0.023082502,-0.06299579,-0.007823064,-0.026693733,0.045975555,0.09918108,-0.0032154836,-0.012114912,0.02380469,-0.07193603,-0.05420688,-0.065047726,-0.061307613,-0.04579457,-0.046650253,0.053374533,0.0032838194,0.011247101,-0.026900403,0.00024660837,0.020415487,0.022486422,0.064075544,-0.015665341,-0.018005367,-0.041391123,-0.03867851,-0.097065285,0.106978215,0.015892483,-3.579039e-08,0.040544283,-0.11087982,0.018306661,-0.052232236,0.030069083,0.045775287,-0.061828833,0.014573548,-0.02165057,0.037199922,0.06391403,0.026727287,-0.056927808,-0.027469212,-0.032832738,0.038349956,0.0010577372,0.07776094,0.052484144,0.055128682,0.004513519,0.017873887,-0.0346099,-0.03576014,0.014588925,-0.05614271,0.023032378,0.07785131,0.06136689,-0.065403946,0.052719668,0.0051134396,0.05139414,-0.04774084,-0.03856973,-0.018201629,-0.017520733,-0.12321136,-0.01997411,0.04679738,-0.0036856437,0.012672325,-0.084790416,-0.0035951454,0.08919852,-0.014549258,0.017530045,0.059173424,-0.023683105,-0.0058128936,0.008698612,-0.04938944,0.0076553915,-0.09652982,-0.08516112,-0.0249899,-0.08780027,-0.033770315,0.030120626,-0.052726157,0.052399147,0.07166591,0.16882646,-0.00037890763 +2.1.1.44,Part of the biosynthetic pathway of ergothioneine.,384,1.0,0.003314087,0.046830595,-0.071346775,0.010255978,0.00886155,0.025151255,0.0049531693,0.03823643,0.05540289,-0.006032327,-0.040599804,0.037124243,-0.015521602,-0.027391283,-0.0073395977,0.05146874,-0.086308375,0.0394958,0.012145402,-0.031069282,0.061086915,0.03360411,0.080446854,-0.030986456,0.05167042,-0.02571527,0.07997367,-0.008962728,-0.0443927,-0.06866104,-0.019106282,-0.114036396,-0.017417282,-0.009218817,-0.014992833,0.10919631,-0.07988704,0.029349871,0.049635787,0.0023665158,0.030763438,0.0026195704,-0.075032935,0.032428883,-0.01677352,-0.027514685,-0.06743122,0.030577239,0.015713373,0.024634639,-0.008213349,-0.038602386,-0.042133678,0.036193486,0.02562871,0.052326858,-0.030415487,0.019300386,-0.05198529,0.02887103,0.114018746,-0.014939325,-0.05715817,-0.050585877,-0.0007725013,-0.030471928,0.084622845,-0.06899026,-0.04989601,-0.03287737,0.013372493,-0.07294734,0.007836409,-0.025648223,-0.009111368,0.004458539,-0.0027906313,0.044531908,-0.064313956,-0.020938601,0.048197046,0.014519665,0.071794495,0.087927826,0.040100515,0.052898012,-0.03992075,0.010071686,-0.050922204,0.09902306,0.05030957,-0.06792276,-0.07418059,-0.01022652,0.037972987,0.021630956,-0.03738135,0.0028720333,0.05650781,-0.00919976,0.023229549,0.06413529,-0.033122495,-0.05261159,-0.016105952,0.03440889,0.01346586,-0.024175938,-0.024767319,-0.07597448,-0.016285412,-0.0023028569,0.046084646,0.04992124,-0.061991822,0.07490136,0.0008790621,0.040314507,-0.04650418,0.059438016,0.022596883,0.026418079,0.022501092,0.030413507,-0.015807368,-0.13948765,-0.07641376,-1.31761915e-33,0.07644342,0.033926312,0.008989861,-0.012003545,0.0046964437,0.12744488,-0.024578573,-0.060251486,-0.037416123,-0.01707966,-0.052903786,-0.10306204,0.037138544,0.004187199,-0.06172349,-0.04965324,-0.039840538,0.04196211,0.090428494,-0.08886007,-0.03051178,0.003861824,-0.07398489,-0.037522074,-0.098876104,0.09686322,-0.044420745,0.0958678,-0.022799047,-0.0020856282,-0.0055863513,-0.032857023,-0.017002039,0.08469562,0.054544486,-0.03884182,0.043716103,-0.013891664,0.042642582,-0.072985694,0.027644668,0.08142194,-0.032195415,-0.000909189,-0.003235022,-0.035097748,-0.038056605,0.014573766,0.09404342,0.07961393,-0.018820243,-0.046813313,0.14302918,-0.031662785,-0.07614776,0.0028981296,-0.04975732,-0.029148592,0.073149204,0.038638107,0.034170296,0.066839054,-0.010373988,0.00060805085,0.106652714,0.07406697,-0.04160055,-0.039985836,-0.094480224,0.053885337,-0.01091191,-0.087740056,0.02778109,0.0344388,-0.040551044,0.0037319865,-0.0874635,0.015277292,-0.058382083,-0.04012858,-0.0066098,-0.036620572,-0.11717041,0.01507764,0.004971063,0.05822411,0.016943093,-0.083969615,0.05994114,0.060812168,0.02663744,-0.07240584,-0.078856714,-0.017407125,0.013276804,-7.1227693e-34,0.10978234,-0.07755064,0.016205816,-0.055800732,0.03194882,0.044016607,0.0145072555,0.023428962,-0.0148268165,0.078019656,0.05046809,0.0027113564,-0.02092929,-0.046144076,-0.03882533,-0.024571309,0.03209056,0.048880894,0.014860333,0.017670125,-0.00473309,0.043501563,-0.039269403,0.07103344,0.004819961,0.040152773,-0.033664014,0.034103584,-0.046858925,0.056035515,-0.06148316,-0.042767197,-0.10131107,-0.05441943,-0.028219769,0.08704398,-0.050709732,0.028690975,-0.026809786,-0.08727446,0.039640892,0.006699974,0.0142690325,0.03431829,0.13354391,0.03696406,-0.038217127,0.030536406,-0.05295058,-0.07860659,-0.022177916,0.060581975,0.071900375,0.011476737,0.025324615,-0.028661443,-0.009153108,-0.064581856,0.022451688,0.018107552,-0.0015587624,0.0018710973,-0.04189367,0.01233709,0.055476885,-0.010116977,-0.015405671,0.07083757,0.055904713,0.050683737,0.037049305,-0.0017160991,0.03998798,0.08067976,-0.101838104,-0.026246475,-0.037907425,-0.07739532,-0.01892628,0.054767992,0.061903924,0.07423648,-0.05535032,-0.04339765,-0.046047945,-0.07005973,0.006754462,0.10443294,-0.037298407,0.008446324,0.040032946,-0.026932018,-0.0733517,0.06830534,-0.0022085954,-2.184583e-08,0.032022756,-0.0437716,0.108960375,-0.07354485,-0.037425913,-0.08917945,0.06375928,0.059844665,-0.0010966221,-0.067150764,-0.021756668,0.042561937,0.048975784,0.0056764823,0.032273103,0.019951588,0.048665434,0.115021676,0.011745093,-0.020809412,-0.019261114,-0.024771478,-0.021786146,-0.056713443,0.076421596,-0.034867246,0.005929554,-0.023961855,0.004264157,-0.02294536,0.06480455,-0.044836137,0.053327188,-0.008694358,-0.06987584,-0.0036581345,-0.056052838,-0.03720582,-0.005471497,-0.124572515,-0.035410758,0.0071281567,-0.0089920955,0.04434363,-0.032643456,0.02178093,0.046632253,-0.03238356,0.03604834,-0.039532736,0.0025269822,-0.013823226,0.0002380897,-0.08549091,-0.09661144,0.009922172,0.006867601,-0.012759777,0.022941066,-0.05901724,0.010876597,0.026631614,0.12802945,-0.03498202 +2.1.1.46,"Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol.",384,0.99999994,-0.06549787,-0.030603388,-0.03682946,0.0065451115,0.066564776,0.02855464,-0.057876565,-0.005723473,-0.046664294,-0.022108926,-0.031574164,-0.037807714,-0.06756255,-0.014728183,0.025416434,0.06941881,-0.07018199,0.079857066,-0.04944235,-0.045912795,0.10358046,-0.018860953,0.041031767,-0.013447157,0.036612783,-0.010370051,0.06250698,-0.010642279,0.10528522,-0.026117425,0.001006524,0.069960915,-0.0053617335,-0.04772052,0.00081876514,0.11169151,-0.022070194,-0.019796837,-0.040576898,-0.09363907,0.075796194,-0.0063239643,-0.013132664,-0.06653877,0.009773097,-0.12955508,-0.0017013135,-0.059021056,-0.00037228878,0.019730054,-0.0854792,-0.06453699,-0.026056746,0.029917605,0.03629717,-0.017887078,-0.014493779,0.04476314,-0.0075903065,0.019514855,0.01645948,-0.033871662,-0.04252248,-0.049906906,0.010178769,0.00022650244,-0.0017065674,-0.055086207,-0.012058693,-0.05389675,-0.025883503,-0.09056017,-0.033865083,0.048341453,-0.0028862157,0.04512833,0.022436423,-0.043268397,0.033429753,-0.036607623,-0.03204046,0.025085704,0.091295645,0.042311553,0.08435876,0.034514777,-0.010074498,0.054860957,0.037552066,0.08866344,0.040416066,0.063258626,-0.0018120358,-0.009896816,0.021499375,0.04657096,-0.035933316,0.0023688225,0.0017304538,0.017755305,0.02522509,0.091915935,-0.10246794,-0.022865057,-0.043630477,0.046767518,0.010855574,-0.022394959,-0.012087737,0.0059322445,0.049137987,0.005339388,0.08203843,0.03269749,-0.048857328,0.05559463,-0.0022904184,-0.09131639,-0.040520057,-0.018040095,0.017659726,-0.0023988474,0.060955163,0.057739504,-0.0430797,-0.017246978,-0.05478196,4.1815875e-33,0.044986393,-0.0054639,-0.010815318,-0.025516048,-0.041853834,0.05158363,-0.053742044,0.04054478,0.003869631,-0.09854779,-0.09300976,-0.069485195,-0.023548953,0.049374744,0.020630928,-0.034061737,0.03982542,-0.05111759,0.07971811,0.025400195,0.02807876,0.007944899,-0.076603286,0.009056463,-0.027944852,0.12237239,0.04848045,-0.03352007,0.0036247796,-0.020222817,0.049485587,-0.18698758,-0.023190267,0.06216934,-0.026505874,0.09888866,-0.025719866,-0.00057015097,-0.019051243,0.059639093,-0.033906862,0.026998207,-0.020581728,0.022664184,0.0074962834,-0.015388451,-0.03142241,0.011277564,0.015365844,0.078481756,0.028471574,-0.0058197295,0.021034438,0.03229214,-0.033737317,0.06425,0.0016859149,-0.017580288,0.05168774,0.015303037,0.0043788785,-0.06909021,0.034654878,0.08014542,0.042752378,-0.0013378845,-0.06163701,-0.013423949,-0.03704005,0.02178892,-0.01352897,-0.023722205,0.07700682,0.021101583,0.04083182,-0.039046448,0.0024784207,-0.002859744,0.027149104,0.028382145,0.027814757,0.045684405,-0.03893715,-0.0074451813,-0.08599283,-0.03502668,-0.042434398,-0.028287569,-0.039564062,0.018882005,0.010481747,-0.04020049,-0.042392295,0.01186578,-0.03559834,-4.7401545e-33,0.051455308,0.010801858,0.050812047,-0.0636114,-0.04566721,0.051786732,0.061731953,-0.13119358,-0.010190694,-0.052443065,0.08637068,-0.03849476,-0.0056848614,-0.014830409,-0.005998872,0.016314115,0.0027041142,0.056639392,-0.015646582,-0.017007338,-0.05144493,0.1540853,-0.03212861,0.09834444,0.05511882,0.023526963,0.010606454,-0.0053870194,0.05455363,0.12098248,-0.01635954,0.06289791,-0.053352885,-0.07329084,-0.02861019,0.09628923,0.025743393,-0.0067455675,-0.0963534,0.03900005,0.002922517,0.06044465,-0.019264264,0.058544356,0.0021114328,0.044374608,-0.082854256,0.03632135,0.0066194725,-0.0494184,0.07385314,0.053090293,-0.010166749,-0.036774915,0.065789215,0.022845725,0.029386371,-0.023709752,0.0056646448,-0.038869504,0.006015426,-0.026156908,0.004187679,-0.04249173,-0.018380137,0.09484306,0.014436163,0.04803477,0.025836779,0.012838683,0.07440566,0.041828647,0.09050186,0.056383535,-0.055226885,0.036895525,-0.015553727,-0.013858807,0.02227685,-0.12341309,0.015996339,0.047101837,-0.012217335,-0.09831402,-0.07691869,-0.083643354,-0.010701884,0.05572219,0.012389867,-0.010430729,-0.05684369,-0.008679078,-0.085596874,0.046415698,0.03443371,-3.6884714e-08,-0.0049865106,-0.11322626,0.05269165,-0.07367596,-0.015416693,0.040603157,-0.008579121,-0.054407317,0.04111744,-0.015754716,-0.015575367,0.04568731,-0.06341336,0.028476253,-0.009449096,-0.02240347,0.00883278,0.04717046,-0.059862375,-0.07780546,-0.07845202,0.028532093,-0.19232465,0.0061172666,0.049299993,-0.054080844,-0.063458614,0.092613705,0.085932024,0.023131784,0.06472855,0.05338636,0.035093404,-0.030365683,-0.039072208,0.026623001,0.0052451454,-0.033567972,-0.024142694,-0.09660053,-0.035228327,-0.029120667,0.0802054,-0.04270803,-0.080723494,-0.033693194,0.044871926,-0.0014006546,0.042252023,0.03330542,0.06796835,-0.057449184,0.013104573,-0.052787535,-0.080314904,0.0166114,0.048007894,-0.044490017,0.0048175,-0.1187805,0.02279304,-0.03680636,0.12908374,-0.028999118 +2.1.1.47,"The enzyme, characterized from the bacterium Streptomyces griseus, is involved in the biosynthesis of the antibacterial drug indolmycin.",384,1.0,-0.016949074,-0.006566555,-0.15810701,-0.049841266,-0.045731153,0.056916956,-0.048226852,0.06853184,0.0839088,-0.011125519,-0.012602924,0.00527213,0.031880252,0.052535992,-0.03258957,-0.0032025636,-0.047731865,-0.032256268,0.077256285,-0.044265945,0.080744535,0.08658919,0.01793459,-0.016924739,0.054904666,-0.00631679,-0.0035356071,-0.008790029,-0.06078478,-0.044290956,0.078702174,0.0012832684,0.06613961,-0.040364753,0.070622995,0.058993623,-0.0672131,0.0091904765,0.181841,-0.0009222876,-0.055615336,-0.03081738,-0.0591843,0.038377658,-0.028142491,0.03860952,0.026758067,0.056686137,0.019192418,-0.014258584,-0.014350201,-0.043423798,-0.06667843,0.056526836,0.08942629,0.013889662,0.0054894444,-0.0044998643,-0.021646783,-0.04713419,0.06406798,0.011455441,0.03160117,0.024230566,-0.1087876,-0.057396874,0.024326805,-0.09322536,0.061241582,-0.01176924,-0.07953362,-0.061010893,0.0018350625,0.036729462,-0.039636448,0.002767328,-0.034201015,0.037549973,-0.04951319,-0.053288393,0.10085742,-0.0053384462,0.0047441344,0.103124,0.045445926,-0.018491244,0.08252889,-0.0028996079,0.08242375,-0.031771813,0.061506454,-0.053541895,-0.008721766,-0.073462196,-0.03915752,-0.023826899,-0.09545564,-0.057621617,0.0010252378,-0.024304394,0.0025511053,0.00952326,0.036892217,-0.02260995,-0.030886868,-0.02076098,-0.01796202,0.06210865,0.034637734,-0.030161401,-0.053319115,0.01358864,0.005174444,0.021548338,-0.035581417,0.034903295,0.12110559,-0.020782178,-0.08621916,-0.008552481,0.01860987,0.046754766,0.017301477,0.036791626,-0.031775683,0.034133907,-0.08138438,6.829729e-35,0.0049724355,0.050600443,0.00905029,-0.09492718,0.058936592,-0.034890164,-0.08445256,0.00405002,-0.00080481503,-0.035087038,-0.09428576,-0.09120221,0.034521762,0.06649006,0.02085598,0.04549579,-0.056442823,0.023405297,0.06421643,-0.016626718,-0.014012826,0.017870447,-0.05823941,0.004358443,0.0045050746,0.05948704,0.00820884,0.050242618,0.08899694,-0.059337247,-0.0031427322,-0.07590906,-0.036880612,0.006081026,0.05171198,-0.04332084,-0.031339012,-0.049042344,0.084312566,0.044062328,-0.0133564165,0.024091199,0.047410402,0.0053072744,0.05819083,0.00016611458,-0.074555114,0.09042236,0.05756645,0.06873854,0.06003338,-0.057182524,0.065493695,0.008198699,-0.076064445,0.053086873,0.004462652,0.043327387,0.023531865,0.0019254704,-0.011091037,-0.017347373,0.036380567,-0.021352505,0.019336043,0.010214798,-0.05612651,-0.046641115,-0.020014817,0.07864802,-0.09595092,-0.014292385,0.027828604,0.01938967,0.0038761331,0.00026602365,-0.043946132,-0.035671413,0.08960261,0.02734516,-0.07604647,-0.00027552972,-0.014627118,-0.0674212,-0.006278639,-0.015010881,-0.0925293,-0.052665286,-0.012526083,0.05265832,-0.012491012,-0.07714332,-0.12461137,0.06744536,0.0043946235,-2.8381141e-33,0.08270719,-0.068220384,0.051595636,-0.028799511,0.016133763,0.07496966,-0.05602757,-0.044091586,0.0089327665,0.00982466,0.0338065,-0.025735725,0.026343767,0.00854051,0.018546125,-0.037776217,0.015151518,0.06975816,-0.06250894,0.030360345,0.024785994,0.06384735,-0.00013052882,-0.07343147,0.025609469,0.01636569,0.011364996,0.04966505,-0.0049069677,0.057053566,0.03602329,-0.06499302,-0.110977285,-0.061888877,-0.02034067,0.10715984,-0.0032566178,0.01946351,0.03176084,-0.06514796,0.06001357,0.049234252,0.014062804,0.063974105,0.06357974,0.012783655,-0.062261548,0.08822173,-0.0017530583,-0.07245795,-0.04048608,0.04982996,0.035848506,-0.034965385,-0.024171984,-0.0009303143,0.0016819875,-0.055913385,-0.02488749,-0.03439269,-0.040824033,-0.06502533,0.039626993,-0.015326543,0.0048982822,0.026708476,-0.00071082806,0.07263802,0.10571011,-0.07815562,0.05105351,-0.026358254,-0.05478399,0.06292758,-0.03795515,-0.033130407,-0.06681326,-0.08061052,0.034565378,0.004134397,0.0073594055,0.010473454,-0.014645892,-0.015306971,-0.052938566,-0.036369458,0.020053877,0.06238756,0.0443634,0.0072575323,0.0064085755,0.053237107,-0.013098111,0.02151819,0.03019492,-2.7448657e-08,0.06787991,-0.025828298,0.07848668,-0.03559758,0.018540198,-0.03742266,-0.04996339,-0.005190579,0.023189176,-0.06728888,-0.024217224,0.038375698,-0.06308056,0.00031531267,-0.002881105,0.040087327,-0.07185661,0.034363396,-0.0036043653,-0.02818966,-0.053788442,-0.012431894,-0.11734294,0.06966139,0.0635174,-0.0633115,0.027213994,-0.031319562,-0.06021327,0.016391955,0.04655782,0.044078648,-0.04674886,0.010489295,-0.046103977,-0.018985381,-0.03705928,-0.009524794,0.03928569,-0.005603289,0.04261677,-0.002129847,-0.06321366,0.020667767,-0.056333203,0.06273295,0.0001179082,-0.03608464,-0.055778403,-0.028868554,0.060352873,0.03621962,0.0026315295,-0.016225295,-0.13631909,0.024532512,-0.03514504,-0.068041846,-0.030364204,-0.061583508,-0.030814001,-0.01668887,0.23073424,-0.01890243 +2.1.1.48,Also methylates 2-aminoadenosine to 2-methylaminoadenosine.,384,1.0,0.064160794,-0.023736764,-0.11598588,-0.030271072,0.007761579,0.030147253,0.001773503,0.04689014,0.01009914,0.009180998,0.03821228,-0.022156725,-0.016621068,0.014051631,0.012303371,0.088540554,-0.05055304,0.008973519,0.07212665,0.034637373,0.05627738,0.008316244,-0.049385607,-0.008964659,-0.019423189,0.09101325,-0.007165875,0.0052016196,0.010981708,-0.011802574,0.0020931892,0.026990125,0.0030382872,-0.02060019,0.047610853,-0.002595004,-0.005971007,0.008809665,-0.020243911,0.014543025,0.026806816,0.055806953,0.029432904,-0.036348335,-0.06788232,-0.01435272,-0.012219224,0.051805586,0.05150283,0.022660973,-0.020996787,-0.065660566,-0.020797879,0.031689834,0.050544057,0.07360276,-0.0938588,0.01654544,-0.052124154,0.050909292,0.0061007054,0.03555258,-0.04997431,0.008074169,0.07608317,0.031648662,0.046605732,-0.020794354,-0.009289702,-0.036402963,-0.022543048,-0.047790352,0.013886392,0.012214852,-0.014763981,-0.03287846,0.038118392,-0.030181682,0.0680017,-0.122094855,-0.08147846,0.016851125,0.036671504,-0.00762756,0.040020734,0.08362097,-0.03110659,0.032249082,0.047646437,0.013878847,0.04769497,-0.038067598,0.07620906,-0.040920116,-0.039998427,0.028541952,0.01206333,0.04754895,0.045060188,-0.019013762,-0.0085930955,0.063534334,-0.14525974,-0.064769335,-0.033104673,0.030731766,0.0038859611,0.026424788,-0.010611999,0.03806126,-0.0028629133,0.039180886,0.0355301,-0.011917774,-0.04995616,0.03880623,0.07467857,0.024366116,0.0055590845,-0.04732565,0.013749833,-0.024436107,0.017844636,-0.021412889,-0.038504984,0.036717486,-0.058681197,1.8912716e-33,0.021898424,-0.0032317084,0.069273144,0.053828366,0.07166819,0.03802421,-0.04337462,-0.022102812,0.07304563,-0.047332257,-0.151267,-0.1085364,0.047203034,-0.0018546961,-0.04685005,-0.028022034,-0.028454246,0.007284909,0.06985318,-0.023820607,-0.06910435,0.16403987,0.017058035,-0.04012107,-0.01708549,-0.003955726,0.045829576,0.015257744,0.09203802,-0.009711909,0.0076928334,-0.047485966,-0.094998345,-0.027044734,-0.007902954,0.03454081,-0.040123615,-0.020150242,0.014669866,0.097939916,0.052475706,0.0053430814,-0.017525254,0.014728093,0.04239085,-0.070039995,-0.03037657,0.04347964,0.027825443,-0.011536478,-0.011489622,-0.021036692,0.029175188,-0.052519813,-0.051844552,-0.0030046862,0.016987963,-0.03487674,0.0070119356,0.06979075,-0.050603002,-0.003587952,0.030510891,-0.06414241,0.0017018407,-0.05703527,-0.05414081,-0.080164276,-0.032497294,-0.028136548,-0.04071168,-0.06650883,0.15461016,0.042618122,0.046298653,-0.057660576,-0.027657872,-0.007721812,0.035401057,-0.0051213684,-0.014805646,-0.00807543,0.075029686,0.014197331,-0.02438724,-0.011904271,0.011008015,-0.09856824,-0.010722121,0.048668608,-0.05326415,-0.045499533,-0.09613799,-0.041962244,0.03456666,-3.2097163e-33,0.0011449571,-0.08625478,-0.0030630473,-0.035990838,-0.02410411,-0.0035100775,0.053543787,-0.050970174,-0.026679682,-0.06294727,0.14343579,0.011277052,-0.03132947,-0.051886804,-0.0006349016,0.026029855,0.009738179,0.1056304,-0.01776659,-0.029073466,-0.023429729,0.040531084,-0.00312589,0.100437894,0.07904476,-0.004706336,0.024574999,0.030363513,0.056302607,0.100526795,-0.01042389,-0.042682428,-0.06199459,-0.07193601,0.014273839,0.043053765,0.012796871,-0.045969654,-0.10307646,0.03562592,-0.06735513,0.05828752,0.06201352,0.095210485,-0.0024844913,0.043709338,-0.056775477,-0.055736236,-0.11934825,-0.02576709,-0.0045395717,-0.07783231,-0.05986014,0.07239877,0.068280205,-0.016703727,-0.036560036,0.01012421,0.015754178,-0.028103964,-0.019547924,-0.04675616,-0.06866023,-0.07747472,0.09251091,0.019581906,-0.061322965,0.012239787,0.02613897,-0.022133915,0.042823765,-0.017651228,0.043992203,0.059836455,-0.066149384,-0.108452246,-0.038907662,-0.099820234,-0.029789118,-0.121087834,0.011047157,-0.03487803,0.024087254,-0.0050901338,-0.04108481,-0.026618542,0.08228996,0.06035453,-0.050545648,0.032069396,-0.047064185,0.026057942,-0.035537675,0.091391854,0.048135787,-2.2413321e-08,0.048113257,-0.06057304,0.034980904,-0.063490294,-0.064640716,0.054738093,-0.06500536,0.036091268,0.020452326,-0.05552597,-0.020380314,0.07378325,0.039503187,0.05810783,0.009333648,0.017098004,0.015395865,0.031774793,-0.04531044,0.029782731,-0.116380535,0.0606153,-0.036684304,-0.035398077,0.016958917,-0.014000124,0.005698363,0.06364197,0.09090108,-0.014101186,0.032121085,-0.03564797,0.065888904,-0.061086252,0.012076243,0.02447112,-0.020737354,-0.03767825,0.0061059985,-0.035449345,0.0003451343,-0.019802244,0.0194418,0.08832867,0.058391973,-0.05881864,0.0007839643,0.13268265,-0.064503185,0.0022509717,0.065194845,-0.014430258,0.023531543,-0.089721896,-0.08641639,-0.07201543,-0.061576977,-0.029513083,0.047486164,0.0050766403,0.009480363,0.026516052,0.18631993,0.00789191 +2.1.1.49,"An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.",384,1.0,-0.0021637436,-0.076939456,-0.05593765,-0.046852726,0.025156008,0.019810578,-0.0043489835,-0.0009030359,0.028047295,0.036638107,0.026493264,-0.05220463,-0.09855799,0.14983405,-0.0013009832,0.052590728,-0.061752405,0.011199842,-0.0022144062,0.024181267,0.024065547,0.054114558,-0.0062149307,0.02194191,-0.10529966,0.047365956,-0.020551398,-0.0532462,0.0075163827,-0.04848168,-0.09491437,-0.033879105,0.049938112,0.03428373,0.0039759246,0.043872908,-0.10348427,0.014984985,-0.011949993,-0.021638807,0.02279766,-0.02024081,0.001506274,-0.08201087,-0.033657588,-0.08679386,0.050516333,0.0017109028,0.018100929,-0.00694078,0.0055836653,-0.01830858,0.00033984572,0.059372857,0.010568419,0.017197609,-0.08508432,-0.03904703,-0.0314783,0.03016709,0.018012552,0.027160246,-0.05517729,-0.054924257,0.047111783,-0.041665357,-0.04503116,-0.02383256,-0.020063074,-0.04060038,-0.013966006,-0.11901341,-0.0028935147,0.022103574,0.074069746,-0.0649044,0.0070881536,0.01887317,0.03057697,0.030308641,-0.046322692,-0.034915924,0.0009779532,0.082965426,0.10480731,0.013972353,-0.05860507,0.10902322,0.038605034,0.057436254,0.014890644,-0.034733064,0.06864615,-0.05579099,0.039295163,-0.024685137,0.075946055,-0.04382079,0.06575559,-0.0127732195,0.04687819,-0.039243795,-0.06561691,-0.05151087,-0.07659561,-0.020048447,0.027138514,-0.021059342,0.04769482,-0.035330977,-0.082983516,-0.03645432,0.105352625,0.03805789,0.01864563,0.056025863,0.008821282,-0.040631063,0.0079837395,-0.047359876,-0.03890794,0.030615684,0.058944955,0.0499479,0.035829112,0.058552913,-0.068895906,-9.394487e-34,0.03481113,0.038636908,-0.0079490235,0.04705678,-0.02822606,0.09275456,-0.021324385,0.073565096,0.018942248,-0.07256569,-0.083561026,-0.020620303,0.032719247,0.11810801,0.047504008,-0.020074045,-0.0069171293,0.009402974,0.12288919,-0.030357543,-0.03084327,0.046614766,-0.03384793,0.033759527,-0.04842295,0.018451082,-0.070800416,-0.010423245,-0.0019373285,-0.026238717,-0.00013560624,-0.04246562,-0.057587612,0.02459943,-0.0062708715,0.095951185,0.019244121,0.03809984,-0.07174907,-0.015965719,-0.029398108,0.049527783,-0.058725767,0.027156435,0.035813913,0.032783356,-0.05798526,0.027544832,-0.015483718,0.037672497,0.011722036,-0.04918436,0.025585748,-0.0674429,-0.06917396,0.06956697,-0.031074975,0.05244714,-0.002692132,0.009991286,-0.0076700146,0.010918964,-0.06431806,0.03776365,-0.054959558,0.016177312,-0.0035693962,-0.08707851,0.063774705,0.07852185,-0.11531399,0.009478976,0.048313167,0.019952426,0.056932125,-0.05340957,-0.043863762,0.022164745,0.05411588,0.028924972,-0.040825125,-0.062549494,-0.020781362,0.052176267,-0.10317249,-0.076643884,0.06736829,-0.0655648,0.025983566,-0.01045702,-0.016033519,-0.094191276,-0.02443339,0.059682608,0.08597771,-1.626887e-33,0.082309596,-0.1143655,0.073308624,0.0041224635,-0.0014527139,0.056352198,0.008380698,-0.11329792,0.047918543,-0.0724558,0.06476375,-0.03296721,0.11688504,-0.007959396,-0.010727434,0.02315276,-0.0568622,0.083669275,0.053352315,-0.016947847,-0.03751306,0.026327547,-0.059461113,-0.056210194,0.018657416,0.042421494,-0.088177845,0.026696471,0.04891903,0.019471098,-0.052739386,0.009623769,0.0032195414,-0.065279156,0.024184711,0.083145335,-0.04600936,-0.009904767,-0.016310778,0.017772615,0.048751686,0.025033312,0.058563434,0.062397774,-0.01276513,0.060638417,-0.03207136,0.007082701,-0.06681721,-0.068849765,0.034506988,0.005240719,0.0066891396,0.008730031,0.10087135,0.033976577,-0.0060875444,-0.053436622,0.007370261,-0.009102242,-0.05711277,-0.06185997,-0.0035990088,-0.00032226587,-0.04045534,-0.070324734,-0.0315747,-0.030743642,0.030311868,-0.027586494,0.06473124,-0.10005387,0.094466686,0.09849793,-0.046264093,-0.108893625,-0.04058228,-0.09025172,0.048441514,-0.061446603,-0.02826696,0.012288286,0.06074438,-0.03623179,0.038886447,0.033154253,0.060063403,0.038566604,0.039280128,0.042486154,0.032014895,0.0032918376,0.0055640414,0.0478007,0.042461503,-3.637191e-08,0.028622223,-0.1039678,0.022183621,-0.043748673,-0.008504041,0.059762046,0.016528009,-0.0011325048,0.008984351,-0.0054570525,0.0469331,0.047284845,-0.016048795,0.010194299,0.047476515,0.025122542,-0.010480302,-0.0022727768,-0.008588778,0.0042429357,-0.14574677,0.025016502,-0.07609201,-0.068092406,0.007273815,-0.035589173,-0.07895003,0.029731922,0.0072814706,0.020797104,-0.008048728,0.003681606,0.078096114,-0.07411435,-0.040637106,0.0903426,0.010455078,-0.08722173,-0.017731026,-0.021673784,0.06938284,-0.081719495,-0.09324733,-0.02111906,0.014768828,-0.027669137,-0.012416909,-0.019178921,-0.01118159,0.013005899,0.027903534,-0.009771601,0.08206651,-0.022803577,-0.047193233,0.023451496,-0.02014258,-0.025280546,-0.00776726,-0.10414968,0.066639826,0.08452002,0.117630616,-0.0013697614 +2.1.1.50,Also acts on secologanate. Methylates the 11-carboxy group of the monoterpenoid loganate.,384,1.0,-0.00045576246,-0.08205451,-0.023188977,-0.030395284,-0.056600086,0.08306482,-0.026614787,-0.033741396,0.042742897,-0.013663287,0.108249344,-0.044737585,-0.068250336,-0.024286924,-0.006739842,0.07148824,-0.022613442,0.022726674,-0.025247335,0.03762282,0.07643961,-0.016850412,0.003254065,-0.02809825,-0.023744991,0.07260597,-0.05487442,0.038979705,0.08614265,-0.07651342,-0.025446462,0.064401045,-0.022064129,-0.0071805906,0.058049895,0.021671936,-0.028052453,-0.046920914,0.07205194,0.032384146,0.09312523,-0.022730531,0.0379913,-0.045298215,-0.008306006,-0.018703096,-0.014333472,-0.028504532,0.0012630189,-0.030199789,0.058603413,-0.11544983,-0.04130796,0.0813348,-0.018789863,0.03705738,-0.014965608,-0.020483673,-0.015053959,0.018253619,0.0029364012,0.01221519,-0.017944826,0.0025596651,-0.02229391,0.005614971,-0.024898859,-0.006372115,0.016510127,-0.06836392,0.024262525,-0.069200024,-0.055333484,-0.023108458,-0.04799433,0.03343695,0.030163778,-0.02720472,-0.0038074863,-0.063500375,0.01802973,0.054334775,0.086004876,0.04016853,0.08148429,-0.0128689455,0.02213611,0.045954827,-0.04012491,0.07015943,0.0063953344,0.021359412,0.028557247,-0.013833493,-0.049767226,-0.0059034363,0.111099504,-0.014801265,-0.025048863,-0.03199225,0.014507842,0.02591476,-0.1507747,-0.039910417,-0.0067275194,0.051525783,-0.02187396,0.00019358618,-0.025313422,-0.040287342,-0.04068297,0.010973294,0.015388426,-0.015444214,-0.07219389,0.048511744,0.041502573,0.038083553,0.030874467,-0.03629331,0.015129505,-0.028315373,-0.007483674,0.046335597,-0.05229511,-0.018358488,-0.043465883,-1.2286256e-33,0.10100693,0.0070742033,-0.01200073,-0.0019664331,0.008790399,0.013617804,-0.079998076,0.006078462,-0.040275928,-0.06178705,-0.06313612,-0.06750526,0.005254266,0.044945553,-0.07360935,-0.00064676855,-0.04515096,0.015310697,0.028229777,-0.13887148,-0.060307328,0.09035858,-0.05109418,-0.0516886,-0.06740865,-0.020658204,-0.020215,0.011546984,0.047285028,-0.016571684,-0.007688916,-0.044471487,-0.08017927,0.06936927,0.0661839,0.080812894,0.021888021,-0.011449416,-0.0067949067,0.04708448,0.0622343,0.0108089335,-0.06340975,-0.012543119,0.055273056,-0.014953321,-0.05676963,-0.005622191,0.10607125,0.009637342,0.011237614,-0.03061914,0.008162527,0.032345567,-0.124646276,0.04215006,0.057120055,-0.0012945053,-0.11139687,0.04927386,0.010821908,0.00445832,-0.027157953,-0.025431368,-0.00060004106,0.07608741,-0.12288789,-0.03593064,-0.037746057,0.0635786,-0.06509067,-0.012601608,0.12317379,0.018674426,0.10689162,0.022981325,-0.042014305,0.013644747,0.011823401,0.055085644,-0.013511759,-0.029896574,-0.019455912,-0.052289106,-0.15518746,-0.013625324,0.03488293,-0.030830126,0.020432768,0.021998046,0.065930195,-0.05719842,0.014202973,0.004701075,-0.05740383,-1.8227081e-33,-0.038475674,-0.07907389,0.015588059,-0.019066965,-0.060518596,0.06771943,-0.029760553,-0.049219593,-0.033546627,-0.0140744345,0.059091225,0.072003484,0.0070993807,0.025471486,-0.023125004,0.0069855913,0.02720354,0.1282048,-0.03282528,-0.037240494,0.003511949,0.033592116,0.016461378,0.10052391,0.04115568,-0.009409933,0.019456442,-0.03864334,0.094388664,0.050876856,0.030943261,-0.032269657,-0.11047734,-0.023435643,-0.054296587,0.057630785,-0.040360678,-0.02892119,-0.08175878,0.04241412,-0.07534105,-0.101980895,-0.029272646,0.12120226,0.10754671,0.02704351,-0.08500804,0.006070702,-0.030532788,0.10101868,0.021100279,-0.0046496075,0.016266756,0.071771264,-0.0064343866,0.037036784,0.017943135,-0.055136047,0.0005049895,-0.007913054,0.027405595,0.011638903,-0.060215756,-0.06616225,0.021508422,-0.00914343,-0.0037227469,0.0023993053,0.08527643,-0.006726082,0.051871654,0.04445736,-0.015707387,-0.019152774,-0.012777425,-0.05475239,0.017791953,-0.19086984,-0.07467467,-0.067009725,-0.03288026,0.03972165,0.03783239,-0.01273827,-0.08353726,-0.038657557,0.04549525,0.09077379,0.0038283877,0.05069355,-0.01695482,0.009673664,-0.024651457,0.08736675,0.032367576,-2.5048863e-08,0.059224833,0.004563163,0.027377691,-0.030876016,-0.040016524,0.013555242,-0.0036422578,-0.013289666,0.06761987,-0.024259986,-0.026263515,0.05487183,0.00096146035,0.04094626,0.054561768,0.0047979923,0.022816148,-0.01087404,-0.019673752,-0.012484964,-0.09559422,-0.0052614342,0.022129674,-0.0021615745,-0.059241854,-0.09298549,0.041106515,0.15699117,0.011124578,-0.020490615,0.07771105,0.05210388,0.0028314083,0.0023146528,-0.04813262,0.09528338,-0.011716118,-0.019089693,0.0057601095,0.03287716,0.028817654,-0.05909022,-0.059936535,0.037119914,-0.0120812245,0.015300996,-0.0036644656,0.016261421,0.045035396,0.04359093,0.042207308,0.013523796,-0.023061302,0.01872396,-0.12897806,0.02567716,-0.02877416,-0.0010777252,0.0736957,-0.012540806,-0.02993891,0.0089198565,0.14869457,-0.045386557 +2.1.1.54,"dCMP is methylated by formaldehyde in the presence of tetrahydrofolate. CMP, dCTP and CTP can act as acceptors, but more slowly.",384,0.99999994,-0.052162543,0.0017460604,-0.06625865,0.0048225466,0.10345645,0.03781988,-0.03134744,0.022689482,-0.03360809,0.050692614,0.049359553,-0.04405089,-0.044390745,0.010706025,0.0067573697,0.0071155657,0.021418432,-0.002424515,0.037189193,0.056953475,-0.07298111,0.006592023,-0.12723894,-0.06703289,-0.0013879928,0.05520082,-0.0032080433,0.013449796,-0.011162871,0.0142623475,-0.05880599,0.06034747,-0.021045962,0.027998533,0.060942274,0.04787826,-0.06142341,-0.032644063,-0.009394456,-0.023885434,0.04364897,0.027942305,0.05358048,0.0014464523,0.007952074,-0.013255372,0.036438245,0.006943985,-0.098794125,-0.06727312,0.04778169,0.04247409,0.036387082,0.06524025,-0.1051675,0.01073186,-0.026735727,0.027695842,-0.020667585,-0.020126412,-0.05679302,0.02283939,-0.10054118,-0.029790007,0.12009544,-0.0751474,0.03478343,-0.0015499796,0.13188526,-0.029136177,-0.051533345,0.013211361,-0.0012199432,0.01892143,0.030436104,0.08478636,0.04935574,-0.058401003,0.14624889,-0.023573728,0.013223724,0.061025545,0.020545585,-0.03382831,0.056316115,-0.025459982,-0.06773269,0.055922072,-0.022651931,-0.050503556,-0.006316781,0.07074583,-0.105649896,0.03219966,-0.07691344,0.0026643316,0.076171845,0.06782818,0.041264933,-0.011979205,-0.023973785,0.068681315,-0.0917611,-0.035323005,-0.009927754,-0.05019734,0.06434774,0.05721183,-0.015475998,-0.008052879,-0.052145634,0.031207917,0.03300633,-0.06350575,0.08185514,0.030839257,-0.013416726,-0.021846352,-0.0007960705,-0.068592034,-0.09470687,-0.038998898,-0.015400242,-0.027667744,-0.0029883282,-0.0021907503,0.042834416,1.6385658e-33,0.028885981,0.051864494,0.00034257665,-0.025819696,0.013449234,0.014637495,-0.055001415,0.0131047815,0.050377123,-0.047356524,0.013927772,-0.034280796,-0.02131851,0.09011856,-0.0744856,-0.0091044465,-0.07309807,-0.0040692934,0.06921205,-0.070010886,-0.044244565,0.16615993,-0.008693693,0.015031229,0.027830543,-0.0012616804,-0.037975233,0.061789934,0.0037624878,0.0043459767,0.059128243,0.01871206,-0.060623262,0.077599935,-0.02749402,0.08102561,-0.06221312,0.0011837014,-0.0017011499,-0.016866729,0.05039773,0.012247046,0.008276051,0.017334377,-0.057520766,0.005025618,-0.123775855,-0.077198535,-0.023406032,-0.015622141,0.055538453,0.031599972,-0.0466878,-0.023627259,-0.043183126,-0.040990986,0.01649003,-0.03609075,0.005699434,0.049314544,-0.01468893,0.039898295,-0.052108247,-0.0029478204,-0.010657449,-0.026925674,-0.046599846,-0.014816971,0.10313507,-0.0103310095,-0.019606432,0.03273123,0.10115103,-0.017337216,0.019938098,-0.015516521,-0.02053567,0.014469892,0.024512928,-0.0066464148,-0.062251,-0.021983339,-0.001277148,-0.018982615,-0.027609231,-0.09838203,-0.042499263,0.0043600905,0.023409242,-0.054981105,0.021378595,0.019746665,0.054666135,0.060213845,-0.026940476,-3.5746342e-33,-0.02372734,-0.030392444,-0.02662038,0.019686535,-0.058073808,0.02463514,-0.050058182,-0.07825492,0.047850676,-0.117217064,0.11612067,-0.040693223,0.025095169,0.017647346,0.08963001,0.023710573,-0.035429455,0.04693825,-0.02799421,0.06431951,0.024965573,0.0017419222,-0.0469361,0.10511931,0.033859964,0.001643611,-0.04495796,-0.030812284,0.12545636,0.06173049,0.02071759,0.10733216,-0.04003189,-0.0170027,0.060096692,-0.005549749,-0.061581254,0.039552882,-0.06333758,0.034807533,0.07974462,0.007458167,-0.047102172,0.055315576,0.02299317,0.06897671,0.027298521,-0.109507196,0.015110043,0.08579914,0.059861567,-0.055214733,-0.051643796,0.028141662,-0.0047888425,0.10990001,-0.023749573,-0.007617468,-0.0048915823,-0.001120872,0.001038349,-0.025575921,-0.042328466,-0.07906662,0.009324811,0.03268935,0.03531288,0.03043753,0.035343766,-0.0062208246,0.09849218,0.069581546,0.016058194,-0.0106644835,-0.049356423,-0.13545343,-0.01387476,0.019491045,-0.038240273,-0.006982409,0.0043686694,0.062321838,0.0921103,-0.040387794,-0.008283146,-0.00020465426,-0.09362603,-0.036752593,-0.035086066,0.01251955,-0.001871952,-0.019561868,0.020486383,0.060510185,-0.025731452,-3.0993693e-08,0.043886285,-0.04407867,0.0066651376,-0.05495625,-0.08231908,0.06182119,0.017681636,0.010574419,0.05208321,0.049011182,0.056138854,0.064330004,-0.024805233,-0.05976573,-0.016432323,-0.034295455,-0.09966942,-0.03607183,-0.0233849,-0.027798094,-0.13263623,0.028199209,-0.0003463561,0.03569855,-0.021774434,0.059371687,-0.005162597,0.060192425,0.047194943,-0.005695707,0.004969221,0.08135912,-0.0061273575,-0.0072345594,-0.025356585,0.01849628,0.14770913,-0.09928781,-0.03706252,-0.0062538674,0.01096654,-0.044193085,-0.099306144,-0.0124707045,0.05131574,-0.065015815,0.033216182,0.023169244,-0.047278974,-0.010685634,-0.030126777,0.03121711,-0.045964982,-0.02368541,-0.06361399,-0.044467963,-0.10659341,0.037144694,-4.5193785e-05,-0.044551153,-0.055554878,-0.0048304982,0.09634941,-0.030143552 +2.1.1.56,The terminal N7-methylguanosine facilitates gene expression in eukaryotic cells and is recognized by cap-binding proteins. ,384,1.0,-0.019034652,0.00032769496,-0.070587456,-0.0386931,0.016081294,0.05304136,0.040255554,0.012107412,0.03579559,0.042926155,0.0018036211,-0.051790595,-0.07871642,0.08816643,-0.03299108,0.058069307,-0.14908046,-0.028437326,0.019008603,-0.057019338,0.048082452,0.099318236,0.0039188215,0.010192615,0.013427055,-0.019501306,0.05423154,0.05114709,0.054655176,-0.04321706,-0.06355505,0.015901515,0.023291228,0.025642704,0.00564496,0.020265006,0.028722115,-0.0513351,-0.025000129,0.021693585,0.04351085,0.030215165,0.0072292523,0.04431847,-0.0463093,0.0063588414,0.019442618,-0.025742577,0.065362796,-0.02877653,0.015823592,-0.084770046,0.022609252,0.018676488,0.03421095,0.07685073,-0.096958205,-0.12555175,0.07239217,0.012253677,0.01006058,-0.039569937,0.016225109,0.016932007,0.106894754,-0.048438914,0.10010005,0.016451927,-0.124670416,-0.0061661075,-0.016350552,-0.01567736,-0.02631382,0.017330972,-0.05451924,0.04987034,0.01994933,-0.013748673,-0.010859367,-0.016428556,0.009965745,0.04288974,0.06312688,0.021575544,-0.016965836,-0.02530456,-0.046749994,0.09501049,0.017259514,0.04479281,0.03269622,-0.01786424,0.07815243,0.008377752,-0.09680662,0.03427963,0.09295503,0.044369612,0.039914936,-0.012188819,0.000819846,0.07975477,-0.06933523,-0.020547312,0.029006673,0.04441582,0.040233057,0.003323064,-0.0859943,-0.014486043,-0.008251647,0.042725492,-0.0083708,0.011720374,-0.049918126,0.011092098,0.021306366,0.0072969347,0.006418586,-0.022148633,-0.077503875,0.016877431,-0.02443915,0.013914793,-0.021578431,0.04092437,-0.074593335,-1.9995091e-33,0.07124453,0.017631691,-0.0029465065,0.0115385465,0.02865633,0.00028789474,0.0114711085,-0.020211065,-0.022913631,-0.04075913,-0.10133505,-0.07061925,0.055498708,0.01697252,-0.039046053,0.054741304,-0.02229141,-0.028589124,0.003265463,-0.02178772,-0.033523306,0.00531558,-0.02075972,-0.12880239,-0.03152344,0.075566664,-0.057945352,0.021508617,0.09750498,-0.044949774,-0.06562617,-0.02400828,0.013778739,0.06293971,0.07250461,-0.022487443,0.024335757,-0.07225662,0.02703025,0.07147461,0.07529297,0.039928604,-0.056055114,-0.045413606,-0.02258464,-0.0058869617,-0.06021435,-0.012383504,-0.022373023,0.08040595,0.01949659,0.0012667218,-0.005630762,-0.07778382,-0.05014605,-0.00990286,-0.07337263,-0.048530493,-0.059015635,0.044691432,-0.039194115,-0.11371378,0.01248902,0.04642654,0.09418823,0.047740005,-0.09459087,-0.05558369,-0.009361895,-0.041559827,-0.0063077463,-0.09927875,0.102165096,-0.017545749,0.026876703,-0.0018613066,-0.057038795,0.0060069575,-0.0148394015,0.056949113,-0.002483333,-0.0045618145,-0.07726481,-0.01706267,0.04963459,-0.00955781,0.049372733,-0.06577719,0.016364036,0.012492625,0.011074433,-0.05624215,-0.059129037,-0.011858398,0.025219161,-1.2145465e-33,0.05942771,-0.03675565,0.012083445,-0.067004174,-0.028668525,0.04409784,0.00039248547,-0.0023834093,-0.07802818,-0.1394559,0.12738073,0.009445434,-0.009665833,0.019118119,-0.038734194,-0.011764735,-0.013451595,0.071990475,-0.013615476,-0.012714509,-0.060022306,-0.04790291,-0.07062316,0.13398606,0.0197411,-0.063723475,-0.019585049,0.026338685,0.012567142,0.068764,-0.019456055,0.019252766,-0.059260547,-0.0046557123,0.043457355,0.02365774,-0.030774616,-0.02733535,0.05871181,0.03082751,0.0002616914,0.018547563,0.0195136,0.01892049,-0.027946353,0.06488099,0.006866062,-0.04451109,-0.016859256,-0.011716266,0.010690806,-0.03203471,0.026149584,0.009473186,0.005762668,0.04381678,0.031078845,-0.021249738,0.052657504,-0.031979855,-0.0035178906,-0.043414082,-0.046909012,-0.021445686,0.048441585,0.039986897,-0.054795183,0.028898342,0.022044454,-0.05834414,-0.005873744,-0.03857967,0.036620464,0.02097413,-0.0887064,-0.07891126,-0.07590144,-0.07441547,-0.024431475,0.012600948,0.0016477102,-0.00602033,-0.021962207,-0.063858874,0.022298677,0.022552589,0.08752086,0.051338565,-0.059091732,0.009280102,0.03182816,-0.05539518,-0.11563625,0.07359399,-0.016208796,-2.5654442e-08,0.05646179,-0.104815714,-0.0062195305,-0.104082696,-0.058060665,0.09297761,-0.025363225,0.054741602,0.04168703,0.03092544,0.0850179,0.028808318,0.002108471,0.12187782,-0.016826423,0.07136683,0.010464338,0.014700827,0.047971923,0.024119113,-0.09403955,-0.008833209,0.012685114,0.011456825,0.03719774,-0.013337267,0.0010998549,0.1933572,0.08362496,-0.10275363,0.04650735,-0.041790064,0.007878789,-0.025192294,-0.0043094545,0.02392393,0.09208386,-0.12968244,0.060665663,-0.0035556422,0.06216119,0.06985597,-0.067010716,-0.009401582,-0.008277959,0.025639487,0.008698486,0.1126104,-0.027613074,0.018815532,0.063658625,-0.009653283,0.01997958,-0.06484657,-0.02080094,-0.021320598,-0.05356976,0.06525904,0.007357606,0.027270494,-0.028178433,0.002526833,0.07069726,-0.11432919 +2.1.1.57,"This enzyme catalyses the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules. This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine [6].",384,1.0,0.041600496,-0.05104937,-0.0840936,0.007532054,0.020040823,0.08150304,-0.00031727526,-0.0040639997,0.004440538,0.0104513,0.024115436,-0.01008849,-0.075602,0.028014079,-0.07662462,0.065944254,-0.14477295,-0.037658907,0.04413747,-0.021542199,0.090497226,0.11940977,-0.020533625,-0.025539191,0.022174668,0.037278123,0.011187283,-0.016210593,0.049141586,-0.056230277,-0.022384074,-0.019524518,0.057393283,-0.006853406,0.019212374,0.09707265,-0.0041184053,-0.026815398,0.06231955,0.075427465,0.041417405,0.010600498,-0.038306095,-0.039132677,-0.017136555,-0.029239854,0.010319524,0.015666006,-0.009726001,-0.029672831,0.034304567,-0.10802771,-0.013509706,-0.04748469,0.018760692,0.018197916,0.0062979595,-0.03945286,-0.009370314,0.008856216,-0.017083319,-0.030814951,-0.05573389,-0.024077266,0.14689262,-0.056372497,0.059304472,-0.011449719,-0.034354586,-0.01254756,-0.08099147,-0.053517953,-0.11850618,0.076292425,-0.04797223,0.018809337,-0.0034850698,-0.022259003,0.09925232,0.027421987,-0.09535041,-0.036218755,0.030335583,-0.020259194,-0.024274219,0.0827868,-0.061507106,0.10855249,0.0023697275,0.020238584,-0.047132447,-0.0010395846,0.023618037,0.0111447135,-0.07419761,0.040404987,0.0035723469,0.046219308,0.06433882,-0.026922807,0.02987454,0.059645046,-0.116305746,-0.08999979,0.052187562,0.05938461,0.053868335,0.026907023,-0.055072892,-0.016739134,0.00048453198,0.035706304,0.031143464,0.018146781,0.0038356201,0.07632295,0.041035384,-0.044667162,-0.030894866,-0.0684347,-0.020490272,-0.06379252,0.01973808,0.018404335,-0.043192934,-0.028117025,-0.12130363,1.26433895e-33,0.08492114,0.017509729,-0.03308598,-0.00014352116,0.03299264,0.052021515,-0.0443259,0.009731399,-0.05122959,-0.013407917,-0.08035654,-0.13600846,0.04045006,-0.04806049,-5.0352366e-05,-0.016119227,-0.016464885,-0.017743317,0.024472574,-0.07183187,-0.0070476467,0.023322243,-0.0010923186,-0.03260235,-0.022895576,0.04626853,-0.011725095,-0.07326947,0.08189542,-0.024646988,-0.017888928,-0.0014370352,-0.083628476,0.028208856,0.06588921,-0.007759388,0.0040212637,0.027919902,-0.0047744396,0.13473,0.07980442,-0.00787832,-0.0090098595,-0.04073674,0.021847963,0.0048841266,-0.11371867,0.051036693,-0.0061230604,0.004313179,0.0217515,0.0018560457,0.070737615,-0.031190122,-0.05439601,0.011674823,0.03841315,-0.05356112,-0.053436853,0.07026922,-0.029653568,-0.046822757,0.01751501,0.055285934,0.04684863,-0.0482495,-0.04003941,-0.06445536,-0.018248651,0.05026414,0.0013951997,-0.047522973,0.07069806,-0.02963635,-0.016985329,-0.0006997812,-0.04325385,0.02212242,0.060953777,0.03526109,-0.01647274,-0.027965287,-0.0038702406,-0.0823587,-0.020607987,-0.028381526,0.015677279,-0.11539141,-0.012815571,0.0713198,0.03419968,-0.028273957,-0.010472791,-0.023550617,0.015278047,-2.5035903e-33,-0.0036330104,-0.054996878,0.019233864,-0.058752846,-0.038375046,0.03422114,0.07551346,-0.082388386,-0.08614849,-0.08197491,0.048593134,0.03262651,0.03281968,-0.021492925,0.0168557,0.030197378,0.043357175,0.062115062,0.025111731,-0.019941023,-0.003545612,0.048956998,-0.046135258,0.07384462,0.051866084,0.0042621754,0.009977231,0.036069527,0.06581828,0.0049667656,-0.013163359,0.014808447,0.024089843,-0.084983125,-0.021792684,0.06619576,-0.011655997,-0.0026163338,0.06932074,0.042261656,0.002840991,0.041555,-0.009525355,0.04401189,0.04097418,0.021816788,-0.098854154,-0.039773103,-0.038477223,-0.04734164,0.06538778,-0.0020551437,0.05842326,0.041939374,0.023181507,-0.008354718,0.0064392616,-0.014991331,0.016789742,-0.019432224,-0.040905733,-0.028764784,-0.037863467,0.019017868,0.05838122,-0.003357157,-0.03226348,-0.021455187,0.007026341,-0.07496272,0.094472006,-0.04497737,0.008998797,0.046472467,-0.049117032,-0.051402736,-0.06302637,-0.015852714,-0.053477097,-0.09045978,-0.034645926,0.03742634,-0.02785815,-0.01169763,0.03345172,-0.12327693,0.059892636,0.11462713,-0.014593101,-0.001533551,-0.039476156,-0.0002934311,-0.07483919,0.09081228,0.032114502,-3.824641e-08,-0.028133262,-0.11391546,9.523187e-05,-0.03245764,0.017214788,0.10214757,0.019612957,0.005550169,0.06295929,-0.049329568,0.0044119926,0.045276813,0.012980428,0.047539193,0.086750016,0.03641709,-0.051993962,0.061664347,-0.0024086675,-0.02728357,-0.07185123,0.06297587,-0.075749375,0.0010424324,-0.083492935,-0.0130295325,-0.006250613,0.19593626,0.08217625,-0.074959874,0.016180819,0.08068722,0.066335246,-0.026465574,-0.04114546,0.045763675,0.061394535,-0.03610425,0.029594466,0.009482558,0.060856145,0.017918352,-0.043808874,0.0035692756,-0.027616305,-0.01487909,-0.007042022,0.09980944,0.07409433,0.0029165894,0.020843653,0.05278659,-0.013916279,-0.055051588,-0.047553632,0.0019133859,-0.048294872,0.004656486,0.011263365,0.015421923,0.03589494,-0.006235984,0.14790365,-0.10009401 +2.1.1.59,One of a group of enzymes methylating proteins; see also the family of histone-lysine N-methyltransferases (previously EC 2.1.1.43) and EC 2.1.1.60 calmodulin-lysine N-methyltransferase.,384,0.99999994,-0.016363205,-0.01265386,-0.1163227,-0.028548034,0.032674607,0.058050666,-0.049199335,0.024888497,-0.04741595,-0.08791284,0.070785806,-0.05477003,-0.026528662,-0.0145867495,0.030690832,0.08921384,-0.1308533,-0.056852326,-0.02681201,-0.057450242,0.00036796846,0.087587886,0.00036867658,-0.016193384,-0.0123808775,-0.01821001,-0.00877622,0.023698734,0.09476399,-0.045527685,0.001875971,-0.050168484,0.0068887174,0.0034410898,0.10605809,0.035807654,-0.004418997,-0.009450952,0.025417946,-0.0063457177,0.065185964,0.049235847,-0.0061179656,-0.055124186,-0.046317194,0.021901116,0.006093557,-0.0048763966,-0.0025386484,-0.015916707,-0.0015788974,-0.07437233,0.04156946,0.010103349,0.0028170866,0.011399966,-0.06431244,-0.03800744,0.015820976,0.03091933,-0.00054800214,0.03094287,0.008923252,-0.036859196,0.040084593,-0.0031270979,0.05046725,-0.056559067,0.04241976,-0.066351816,-0.06924828,-0.10225707,-0.025060786,0.10241046,-0.020031996,-0.016318718,-0.011357134,0.059262183,0.0039237114,-0.060568597,-0.041567065,0.0004571906,0.013219221,0.006697188,0.00723014,-0.052525513,-0.05905535,0.06866259,0.045119,0.019832479,0.023258718,-0.07975527,0.053007483,0.0011444541,-0.036863815,0.04904734,0.031751607,0.07160595,0.006381389,-0.013323823,0.023376532,0.047693264,-0.08037264,0.009233323,0.0057391017,0.044270746,0.022909755,0.06151283,-0.012216785,-0.05746177,-0.04664779,0.014803061,0.018188013,-0.0030494996,-0.008650777,0.01068795,-0.021522127,0.0014245654,0.07522465,-0.03985937,0.04424729,0.024934571,0.06286304,0.049436424,-0.016458435,0.026270809,-0.18446207,2.342376e-34,0.05201201,0.04627896,0.008548385,-0.01720238,-0.025818348,-0.03799194,-0.08268821,0.0730126,0.025876917,-0.0830467,-0.03968431,-0.051295765,0.06318001,0.05589386,-0.08380683,-0.0518121,-0.012404187,-0.03482473,0.012504566,-0.0304524,-0.11152384,0.084030636,0.0015245343,0.02133805,-0.020383041,0.027351242,0.03957742,0.014426068,0.04248105,0.0022308188,-0.07079404,-0.096433796,-0.02267183,0.025876382,0.058460727,0.06955111,0.031746086,-0.010707388,0.042403772,0.06639844,0.008096137,0.019030256,-0.021765014,-0.056064155,0.004552013,-0.0012911541,-0.084028594,0.0020099557,-0.009801021,-0.013703792,0.0038312,-0.05260114,0.03463833,-0.051939853,-0.04693729,-0.014382852,0.004313022,0.0060661305,-0.029321842,0.08098494,-0.046581972,-0.01209746,0.0021515535,0.034295417,0.02679679,-0.023136048,-0.06095332,-0.034287844,-0.02429163,-0.0015754235,-0.039248515,0.005822059,0.12941357,-0.055767078,0.06907163,-0.09675268,-0.104765125,0.018250491,-0.06495856,0.05953105,-0.0065585584,0.01092135,-0.049415052,-0.058357373,-0.074074835,-0.056102015,0.03924753,-0.061866187,-0.011864057,0.011378646,-0.07381906,-0.059217297,0.042092558,0.05436654,-0.034192476,-3.2380417e-33,-0.01182856,-0.019264866,0.04356714,-0.041625075,0.016681962,0.008306263,0.10472152,0.0007612376,-0.013439002,0.0015810957,0.09883982,-0.0045271073,0.0447922,-0.080556564,0.06799687,0.06568921,-0.018270139,0.099992245,0.04118188,-0.005201096,-0.030272126,0.010695945,-0.056812316,0.09089951,0.026073815,0.04895928,-0.087618016,0.079847395,0.09169767,0.0517695,-0.096658505,0.028124899,0.029185023,-0.07430226,0.07057974,0.03423978,-0.042287815,-0.04715377,-0.058863644,-0.039427515,0.04444082,0.059363224,0.023540063,0.074955165,0.02083068,0.13495418,-0.04235263,0.011062032,-0.08354089,-0.060564354,0.03314733,-0.015808092,0.031170703,0.09107938,0.013798234,0.035247907,0.045313254,0.091264024,-0.06316834,0.04953606,-0.04041529,-0.05124636,-0.038288068,0.055013686,0.0105700055,0.0012735092,-0.08503866,-0.035392858,0.000120354634,0.06341041,0.062399283,-0.014991137,0.014636025,0.02832315,-0.079351455,-0.02399305,-0.07466614,-0.06895879,-0.07084861,-0.04871224,0.009863284,-0.03512363,0.034358177,-0.033705503,-0.008927879,-0.01807136,0.027183685,0.06448253,-0.009638288,0.014427307,-0.0032839186,-0.03593348,-0.115163684,0.08769251,0.031157674,-3.688333e-08,0.070335165,-0.12942629,0.03692414,-0.04958877,0.016690591,0.048429117,-0.007138289,0.028386561,-0.01254995,0.053172626,0.027776515,0.014745234,-0.03455818,-0.041340362,-0.07004388,0.0011101868,0.0012951969,0.08119848,0.019839093,0.019183382,-0.0028512375,0.020667212,0.0214282,-0.03592001,-0.018678635,-0.009497575,0.003851727,0.07041011,0.07638049,-0.10019345,0.062519655,0.025509138,0.042420488,-0.07494272,-0.048111442,0.008406341,0.033520732,-0.09762038,0.031455908,0.06626562,0.0051278956,0.0006700759,-0.08685693,0.0068171197,0.05303226,-0.025457295,0.010746531,0.028289545,-0.013288875,-0.0012865557,-0.005982796,-0.00064293307,-0.045586392,-0.09211729,-0.081175014,-0.023764668,-0.113032624,-0.013554098,0.008445429,-0.057657067,0.0380961,0.055432826,0.18186897,-0.020740231 +2.1.1.60,One of a group of enzymes methylating proteins; see also the family of histone-lysine N-methyltransferases (previously EC 2.1.1.43) and EC 2.1.1.59 [cytochrome c]-lysine N-methyltransferase.,384,0.99999994,-0.04368288,0.015647862,-0.12569012,-0.040316362,0.009018491,0.079705045,-0.06618332,0.038891576,-0.019208513,-0.077316105,0.045341756,-0.059038606,-0.02574516,0.0021742317,0.02660785,0.08706301,-0.14441846,-0.054828096,-0.026406381,-0.050460454,-0.006178925,0.06590727,0.006344995,-0.01869475,0.00065468985,-0.011424371,-0.00556373,-0.007685328,0.039232083,-0.036059543,0.0005251843,-0.0351619,0.024670903,0.015722414,0.105396174,0.05083475,0.0041832686,-0.02700134,0.020166969,-0.00354751,0.04369236,0.07737665,-0.015704641,-0.011523844,-0.04022314,0.029935244,0.013766003,-0.013905048,0.0018393645,-0.011206314,0.034109943,-0.06685516,0.033301115,0.01176683,0.018690558,0.01587224,-0.087251246,-0.047254656,0.018555002,0.025562886,0.02159628,0.042567417,-0.009560514,0.00077152514,0.03894123,-0.00967009,0.056378912,-0.055162475,0.036595404,-0.091063485,-0.07899259,-0.11211978,-0.04273429,0.099295385,-0.021306282,0.009941709,-0.010855841,0.056024075,0.008536319,-0.08223747,-0.058715932,0.011716412,0.020401297,0.028825518,0.021467892,-0.057226848,-0.05444036,0.07133606,0.027950494,0.019046275,0.0003246606,-0.066963166,0.034701068,-0.010195133,-0.04743569,0.02397687,0.06719286,0.07149302,0.015319564,-0.014608707,0.054091472,0.075412266,-0.05598781,0.006429708,0.009224251,0.04012862,0.018048447,0.09082254,-0.0110718245,-0.062614806,-0.03631712,0.011517768,0.012297609,-0.022559848,-0.017976824,0.031886276,-0.0023863218,0.010256702,0.055505186,-0.0037773396,0.015179761,0.014348399,0.03399828,0.021046806,-0.021140404,0.019928593,-0.17990781,-2.1427134e-34,0.042420253,0.06766029,0.01616158,-0.03378675,-0.012454679,-0.020951942,-0.08280375,0.083242804,0.026612017,-0.085842185,-0.049432926,-0.034151204,0.05941203,0.038842846,-0.06154394,0.0033720257,-0.017593049,-0.032246836,0.043175176,-0.05591753,-0.0993895,0.07956246,-0.006663215,-0.012163335,-0.024811167,0.023221174,0.031792317,-0.0054422235,0.016303636,0.0074013732,-0.07345021,-0.08640609,-0.0104206465,0.012044622,0.055577837,0.05915862,0.050095454,-0.012574196,0.027300566,0.09202769,0.0045300345,-0.0071508577,-0.013709775,-0.07256439,-0.0004807143,-0.021959754,-0.11159951,-0.008563401,-0.025852341,-0.006170098,0.012993936,-0.0788246,0.034867447,-0.02951097,-0.03773913,0.012492016,0.0028553042,0.01050839,-0.032055873,0.069591746,-0.00885651,0.018123921,-0.0018787689,0.0707313,0.031071313,-0.06613749,-0.04874311,-0.005214467,-0.049001187,0.027052477,-0.051552515,-0.011941755,0.14718664,-0.063015595,0.077960856,-0.06774645,-0.113291085,-0.0033371628,-0.034072757,0.079228416,-0.019213734,0.0056724898,-0.030288255,-0.10290381,-0.0316707,-0.03913987,0.05625415,-0.094068125,-0.028261036,0.0290806,-0.07331894,-0.07251518,0.028511029,0.014695642,-0.018450608,-3.5727024e-33,-0.01787736,-0.005654965,0.04664519,-0.08978427,0.013669915,0.0002443453,0.10258511,-0.024322826,-0.03108732,-0.004208628,0.09306699,-0.009186143,0.059675258,-0.05596024,0.038181376,0.036263797,-0.021978114,0.07734569,0.03245651,0.014810992,-0.023634333,-0.009531498,-0.049902923,0.08589561,0.024195716,0.029431963,-0.079258114,0.08902406,0.11676146,0.043862548,-0.0937346,0.035508934,0.025408095,-0.08964961,0.07479217,0.05671045,-0.03538402,-0.030844228,-0.032740608,-0.03175992,0.026643371,0.043280274,0.0063224835,0.07920939,0.032367833,0.11777408,-0.056567747,0.028604282,-0.040799677,-0.056655362,0.009240514,-0.0112069985,0.011946957,0.107943766,0.0072205933,0.056275833,0.049235776,0.08811308,-0.059010126,0.037102655,-0.048744857,-0.050731286,-0.026456684,0.05747038,0.012480467,0.0048359497,-0.0971892,-0.008270514,0.005061976,0.054779127,0.051005285,-0.020602323,0.017799854,0.031197445,-0.08961753,-0.03932525,-0.07203931,-0.0661147,-0.07817134,-0.040577095,0.030284818,-0.02941411,0.032016736,-0.026529476,-0.0013917007,-0.051971562,0.009415323,0.06361891,-0.013581827,-0.014958581,0.008575323,-0.011620362,-0.12755215,0.06226495,0.01261777,-3.6909675e-08,0.054829713,-0.11851885,0.064245224,-0.05116958,0.017411526,0.04423511,-0.029246975,0.014232999,-0.013357801,0.037304454,0.032080885,0.03984161,-0.05596232,-0.046923473,-0.060977776,0.008009072,0.0028319827,0.066810496,0.03616594,0.014198556,-0.021243459,0.011054977,0.03446361,-0.038269266,-0.01636999,-0.0300805,-0.0032781032,0.063826665,0.07150433,-0.09027311,0.08243234,0.03114534,0.051637784,-0.049767576,-0.036203835,-0.01344296,0.040954795,-0.088514425,0.024348453,0.034942087,0.007766324,-0.008431045,-0.10310528,0.03749963,0.066996105,-0.025918063,0.018810209,0.069458984,-0.022467608,-0.012037899,-0.031005932,-0.004804795,-0.040158108,-0.10720611,-0.05837101,-0.008086614,-0.094248064,-0.016502265,0.014962647,-0.059222948,0.02993446,0.037263084,0.17274904,-0.024305198 +2.1.1.61,This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate.,384,1.0,-0.014602745,-0.040249452,-0.088482544,-0.026817286,0.06271586,-0.009749534,-0.041161504,0.038003594,-0.032816082,-0.00030749087,0.058814336,-0.01753525,-0.06449479,-0.017442096,0.03203231,0.07432946,-0.0766254,-0.0032653324,-0.0069139265,-0.10263548,0.08586665,0.014216923,-0.041466586,-0.046365254,0.012544791,0.088659905,0.027783295,-0.00068089995,0.01645449,-0.033176497,-0.083462976,0.025914622,0.030859834,-0.03921234,0.020575613,0.10875202,-0.082579866,0.022903314,0.0025828036,0.00294325,0.06986664,-0.037531182,-0.010680084,-0.022259813,-0.09161752,-0.031584926,0.038860932,0.016174674,0.033121053,0.07084644,-0.036276042,-0.06838903,0.0076001156,0.0674999,-0.06775421,0.017489176,-0.040539417,-0.01202504,-0.06404959,-0.038505618,0.049128544,0.0075800647,-0.035845358,0.025245111,0.041311596,-0.020618081,0.011883606,-0.037638713,-0.0055524684,-0.02782447,-0.02864611,-0.052850243,0.053040043,0.04258225,-0.015449835,-0.038480856,0.053665057,-0.027932493,0.1144168,-0.0008106511,0.021009343,0.08183396,0.03823467,0.05050445,0.0071057603,0.056189407,0.0027935824,0.059049267,0.037394326,0.004190903,0.051617958,-0.0011155395,-0.06908158,-0.07305392,-0.08816016,0.021618353,-0.031766992,-0.005149157,0.02332983,-0.018415999,0.03347022,0.020082945,-0.10249276,-0.074916884,-0.024621326,-0.0057113026,0.031608447,0.024339126,-0.025253428,-0.018327974,-0.019427149,0.021421475,0.07173327,-0.007306629,-0.019530486,0.10387564,-0.00226181,-0.016005415,-0.03270268,-0.058058817,0.03937556,-0.008966153,0.06517671,0.03294566,-0.09072521,-0.013765682,-0.15732148,-1.7510807e-33,0.058223665,0.08359784,0.011496374,-0.04289264,0.07796139,0.018441983,-0.039763063,0.037525024,-0.020508207,0.0014918187,-0.116221964,-0.14719705,-0.00952564,0.0117318425,-0.07160051,-0.034604292,-0.03485731,0.07462191,0.0604561,-0.04046183,0.0023658231,0.103863776,-0.071776524,-0.013954901,-0.028451573,0.13921492,0.011824521,0.043881923,0.08338204,0.010334413,-0.021423018,-0.06703587,-0.046326946,-0.044774957,0.061191168,0.04534719,-0.00845429,0.04262994,-0.013357125,0.08101543,0.056142874,0.0456847,-0.04418042,0.001311147,0.035447508,-0.098902576,-0.06233096,0.024189917,0.05526836,0.024209306,-0.02724152,-0.0662999,0.09687602,-0.067800306,-0.087589666,-0.007912569,-0.015695117,0.014996594,-0.029674992,0.020148609,0.008858937,-0.031825885,0.008549083,0.0120292045,-0.009494329,-0.01333903,-0.020052105,-0.05997289,0.013124448,0.08938563,-0.04522035,0.027264839,0.077889435,0.061938576,0.054164574,-0.031417236,-0.018920096,0.0128531465,0.0028505635,-0.00068577094,0.0018948135,-0.052773386,-0.019909218,-0.02332058,-0.022643434,0.022696124,0.022938726,-0.058199067,0.0120148705,-0.008837984,0.03021455,-0.10852865,-0.045003254,0.058619514,0.010792774,-2.0000315e-34,0.059776496,-0.0653387,0.06798872,-0.06943013,-0.04501588,0.042357232,0.03087358,-0.027272247,-0.019361045,0.01316592,0.10366279,0.05545684,-0.024451911,0.010225434,-0.0014401801,0.041355673,-0.00503925,0.047544315,-0.014735219,-0.0116424225,0.04931641,0.018067323,-0.020854065,0.055430986,0.079774216,0.042297706,0.009767143,0.019327072,0.07461462,0.06333475,-0.03638656,-0.05043336,-0.0554097,-0.05753159,0.01135438,0.079153836,-0.02100024,0.0029575403,-0.047167398,0.05127731,-0.024776027,-0.004481113,0.035689533,0.10670014,-0.055941362,0.018703409,-0.054423682,-0.060456384,-0.021617685,-0.068683244,0.042030323,-0.029689364,-0.015096423,0.042018816,0.021986285,0.04753466,0.013818673,0.052541446,-0.067304485,-0.07600466,-0.097027324,-0.060213838,0.0033320226,-0.07041213,0.051159006,0.022678873,-0.048007242,0.02088669,0.019100608,-0.0058043026,-0.0071935975,-0.0034849276,0.02528284,0.047843836,-0.013512875,-0.07041497,-0.0347016,-0.06379706,-0.012344754,0.014232861,-0.024498729,-0.0584886,-0.033738717,-0.04379575,-0.044329073,-0.037673872,0.084678605,0.1500978,-0.034978934,0.0613782,-0.051666163,0.05822109,-0.08113936,0.055724677,-0.01218184,-2.8625749e-08,0.0035613435,-0.15565096,-0.05679087,-0.054709777,-0.031460878,0.05418168,-0.09666027,0.007752877,0.054806143,0.0017940501,-0.0043749157,0.09826927,0.01949971,0.04869536,0.011882759,-0.0023093927,0.0021909438,0.020112336,0.026321221,-0.056341708,-0.08412218,0.00474367,-0.0190152,-0.02549355,0.06609597,0.008145005,-0.0031707983,0.047007643,-0.026696242,0.00215713,0.018676689,0.032209113,-0.036556114,0.021521155,-0.033284657,0.1361093,-0.068185695,-0.030905375,-0.060913213,0.04319279,0.059468675,0.01870896,-0.045045953,0.070059754,0.012347634,-0.034516018,0.046706192,0.0616884,-0.020732448,-0.0407261,-0.017867573,-0.0358616,-0.024403498,-0.058038827,-0.06607034,-0.016507974,-0.0097862575,-0.041456714,0.0008022165,0.032122318,0.02109107,0.090201825,0.18120569,-0.09100695 +2.1.1.63,"This protein is involved in the repair of methylated DNA. Unlike EC 3.2.2.20, DNA-3-methyladenine glycosidase I and EC 3.2.2.21, DNA-3-methyladenine glycosidase II, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide. Since the methyl transfer is irreversible, the enzyme can only catalyse a single turnover.",384,0.99999994,-0.018837567,0.0039167833,-0.065291315,-0.038318366,0.049541164,-0.010834667,-0.020460544,0.012962365,-0.022455968,-0.054995947,0.07074788,0.07230202,-0.057344526,-0.044214796,-0.017545762,0.049581658,-0.066604584,0.008255422,-0.061014395,-0.055937584,0.056288976,0.04967515,-0.007196623,-0.033144496,-0.044950336,0.037816837,-0.018600294,0.010597275,0.047428887,-0.09868993,-0.026655618,-0.039555438,-0.02783388,-0.010050882,0.028280985,0.09408697,0.012548359,-0.042933617,-0.015617945,0.029572133,0.07231672,0.03361565,-0.05493231,0.021622699,-0.08652705,-0.015837146,0.038119677,-0.0031555132,-0.008126046,-0.00019586801,0.02992536,-0.064538375,0.036759235,0.004902833,0.0110502485,0.09716325,-0.03443209,0.009636971,-0.02289865,0.06059389,0.084509574,0.03410134,-0.024232257,-0.004899961,0.07531012,-0.11098459,0.15313797,-0.12597273,-0.057185244,-0.03870393,-0.03003855,-0.115596466,-0.08092724,0.03183117,0.04257848,0.06855265,-0.014088343,-0.079928726,0.05095523,0.029928498,-0.016388526,-0.04539449,0.04980134,0.029269993,0.02187029,-0.038433064,0.015641628,0.06936347,0.014239259,0.063330024,-0.026969418,-0.026295926,0.033688486,-0.023443202,-0.0606395,0.0710644,0.0425147,0.034118254,0.031708598,-0.015466905,-0.0067224074,0.07992604,-0.08565028,-0.053930797,-0.01941906,0.019195978,-0.0070576747,0.098649696,0.007714324,0.0026350864,-0.023751942,0.071164824,0.041449763,-0.009652981,-0.053313345,0.06832804,0.013854537,-0.007161121,-0.010598003,-0.0239267,0.040326178,0.0026962366,0.044731107,0.0072132945,-0.06655596,-0.0441844,-0.03825095,2.0910584e-33,-0.00068072556,0.06393605,0.013276829,0.026503822,-0.0062131705,0.029892866,-0.040247675,0.033039074,-0.023418337,-0.024739996,0.012271044,-0.08867717,0.058200445,0.09264634,-0.09049067,0.002465114,-0.025860917,-0.0024131916,-0.00687435,-0.050220966,0.006511907,0.0523956,0.009812157,-0.04920392,0.04957323,0.070492715,0.019276556,0.04601141,0.09171812,-0.013431832,-0.03515618,-0.074587725,-0.09082754,0.022884756,0.012394207,0.02973137,0.036177527,-0.083116755,0.057002988,0.102576986,-0.033770557,0.010684895,0.013085969,-0.035035923,0.0005035162,-0.041505355,-0.030104604,-0.007734118,-0.021469187,0.021093387,0.050259594,-0.06042618,0.05645985,-0.0487552,-0.09042053,0.017381972,-0.00042880175,-0.034363776,-0.06716019,0.056870326,0.021486884,0.0051770234,0.003479747,0.018968234,0.05929065,0.00023630602,-0.086380504,-0.053853672,0.0061432323,0.03823902,-0.04209627,-0.051008716,0.12294202,-0.016489802,-0.004420444,-0.039764635,-0.10884567,-0.023277532,0.0040911147,0.04205284,-0.046869718,0.009414249,0.023875255,-0.037921984,-0.03867599,-0.013220635,-0.018065184,-0.071218,0.05076123,0.019920755,0.020793883,-0.038330946,-0.013787717,-0.01859098,-0.0016419416,-4.681838e-33,0.09481339,-0.086850226,0.08391746,-0.084571175,-0.00026742695,-0.004688497,0.033457644,0.081694916,-0.022010794,-0.08796951,0.052254736,-0.022799948,0.015479658,-0.047729485,-0.03834121,0.005179463,-0.052613106,0.05153901,-0.039917603,0.028972395,0.056572534,0.032164488,-0.007524298,0.14062822,0.013195656,-0.0011741458,-0.05703302,0.015845664,0.07427375,0.032738045,-0.027211577,-0.056273296,-0.017918907,-0.026741713,0.06087576,0.09121822,-0.043349445,-0.028358549,-0.018298438,-0.018417673,-0.02738489,0.07366252,-0.019572912,0.069362976,0.070514694,0.11847981,-0.055265993,0.018947404,-0.014274893,-0.04767209,0.021954136,-0.012171014,-0.002066139,0.075762995,0.049343273,-0.01607594,0.0521548,-0.049362034,-0.023454133,0.01789053,-0.059456293,-0.011565234,-0.0074914605,0.026459115,0.10322362,0.03465199,-0.03408942,0.008271452,0.017690964,0.026337534,0.08573557,-0.017338406,-0.025983993,0.0045036245,-0.00076917344,-0.005569852,-0.11510735,0.010582797,-0.04833435,-0.060439512,0.05122308,-0.040189162,-0.0071709305,-0.019104842,0.061350428,-0.010188558,0.03603341,0.08251982,-0.051087964,-0.06817983,-0.0645025,0.0068557346,-0.058789965,0.050095115,0.013947279,-5.037584e-08,0.065777294,-0.107383,-0.02382988,-0.11504323,-0.034019426,0.055047225,-0.060439475,0.054971766,0.08595131,0.0012949347,-0.07266282,0.042336755,0.011094286,0.024337083,-0.03536338,0.043609247,-0.051136676,0.058681842,0.044725016,-0.014586119,-0.14953215,0.04664924,-0.083074346,0.023528919,0.0039385236,0.06189876,0.0197876,0.10209603,0.0018335935,-0.030681208,0.0632942,0.018252218,0.03052725,0.088199005,-0.06196955,0.0014306564,0.004081027,-0.026479147,-0.037370257,-0.028469268,0.023796218,0.04912392,-0.08211678,-0.0026878642,0.037229467,-0.038681354,-0.022330347,0.053291988,-0.06702601,-0.043150526,0.050892126,-0.034312587,-0.037853196,-0.073272794,-0.09674818,-0.06398874,-0.051794086,-0.03965521,0.009756183,-0.029804641,0.027264133,0.010440502,0.17848043,-0.08126835 +2.1.1.64,"This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast [3]. The enzymes from yeast, Escherichia coli and rat also catalyse the methylation of 3,4-dihydroxy-5-all-trans-polyprenylbenzoate [3] (a reaction that is classified as EC 2.1.1.114, polyprenyldihydroxybenzoate methyltransferase).",384,1.0,-0.021932311,-0.008798785,-0.0962035,-0.049018543,-0.014385942,0.079932995,-0.041227978,-0.017914271,0.033068877,-0.04048608,0.022892442,-0.022724973,-0.0751917,0.00757126,-0.023164943,0.038450684,-0.07837931,0.012712167,-0.058286093,-0.036488507,0.068281256,0.01756311,0.004753019,0.020459138,0.049081992,-0.07226906,0.04589136,0.024217764,0.0059528947,-0.04097911,0.009536406,0.015995072,0.037673593,-0.080070764,-0.025221443,0.093531504,-0.022776445,-0.07709938,0.039050527,0.08279122,0.036476813,-0.06427994,-0.03887956,0.085273966,0.037638813,0.043557584,-0.0548831,0.04264522,0.07468838,-0.00613803,-0.019547885,0.032088436,0.04584655,0.059355423,0.06104151,0.02188894,-0.04320345,0.050199818,-0.0096791405,-0.03226388,-0.008046188,0.02512092,0.047421068,-0.002816743,0.020720538,0.052494884,-0.034474075,-0.07392297,0.040338103,-0.0016093305,-0.04249506,-0.058573265,-0.04655182,0.0031125231,-0.0701519,0.12633091,-0.046904817,-0.013330109,-0.025335632,-0.024424683,0.01158991,0.0034835043,0.11551588,0.0012240926,0.052811295,0.008790453,0.021931909,0.004974553,0.04983248,0.05522495,0.014636926,-0.013206031,0.00856733,0.013854516,-0.019591698,0.04417587,0.055209085,0.07295115,0.045940723,-0.019745275,0.065831356,0.052048374,-0.044003766,-0.05729952,-0.016524104,0.058998946,0.07172467,0.10691949,-0.0008144628,0.011279466,-0.04951075,-0.023750488,-0.010158829,-0.0030787666,0.021894509,0.009104833,0.10570247,-0.015775088,-0.017832931,-0.043828826,0.009882996,0.047235675,0.06934722,0.008741574,-0.042692516,-0.0099437805,-0.1160572,3.1034726e-33,0.069629215,0.036911465,-0.0036997881,-0.012484967,-0.042246234,0.020816466,-0.07363425,0.036011063,-0.08296723,-0.065790184,0.003169593,0.011366313,0.041324902,0.054438893,-0.016214104,0.012237729,0.006176142,-0.07458745,0.07814179,-0.02242614,-0.038995877,0.002356252,-0.1016811,-0.018676225,-0.027769027,0.018266283,-0.0506351,0.05450577,-0.084537916,-0.009525032,-0.07426686,-0.06142265,-0.06942879,-0.008380939,-0.05015015,0.004139626,-0.09769317,-0.008142772,-0.02873678,0.022748822,0.04113847,0.003557258,-0.012221873,-0.036517352,0.06214508,-0.014647076,-0.025998369,0.070490114,-0.034357738,-0.014136842,0.0063147927,0.08788139,0.061713632,-0.02084921,-0.09289627,-0.010624016,0.05176062,0.060774967,-0.01570014,0.040797193,-0.09014261,0.03959171,-0.012843385,0.07092439,-0.036333647,-0.03480562,-0.012661818,-0.022361826,-0.077174544,0.08142126,-0.032546762,-0.07973304,0.019560637,0.015622427,0.05357333,-0.04737754,-0.033858165,-0.044269346,0.04761308,-0.019640427,-0.072199725,-0.041317277,-0.016015021,-0.044269055,-0.06310032,0.03186517,0.020867579,-0.053005856,-0.0615104,0.029403025,0.1067907,-0.043508396,0.0015400846,0.047591444,0.034461364,-5.0058328e-33,0.06001052,-0.031106798,0.03282384,-0.070399664,-0.04253199,0.0781718,0.093780875,-0.028152507,-0.029841438,-0.05195611,0.12984668,-0.050167464,0.018128311,-0.013187694,-0.003484167,0.013978013,-0.01477789,0.084119014,0.06816261,-0.0010545807,0.09539851,0.090847835,-0.08827957,0.03653832,0.030290626,0.048021037,0.014192375,0.0036432222,0.032306917,0.059947193,-0.026698405,-0.025843054,-0.033521496,0.011022556,-0.017571986,0.030327233,-0.06278818,0.03350441,0.02578397,0.029871829,-0.005208681,-0.029939415,-0.07177746,-0.004485347,0.027091788,0.13723291,-0.056633838,0.011751868,-0.031078432,0.018277101,0.053443145,0.023563586,-0.06964339,0.036042437,-0.011943207,0.05166294,0.037515026,-0.077756494,0.026441569,-0.01584011,-0.023020802,-0.016781397,0.054605808,0.01952571,-0.032765437,0.064624876,0.01695062,0.0639542,0.005301341,-0.05669439,0.04050824,0.0178312,0.007795798,0.037949815,-0.087784015,-0.03331183,-0.08570828,-0.070114516,-0.024492394,-0.009128798,-0.0065259,-0.05754279,0.026962155,0.00939878,-0.07169589,-0.07729099,0.070007786,0.082089484,-0.049794875,0.0894612,-0.016103577,0.04127517,-0.11117684,0.02237144,0.043498203,-4.3137234e-08,0.043922152,-0.08087035,0.05265944,-0.07617945,0.027586889,0.007500725,-0.02980957,0.06372881,0.025785789,0.03510657,-0.04748248,0.011827771,0.021350356,0.07492767,0.037192017,-0.036458332,0.009518032,-0.008631577,0.003726415,-0.07462651,-0.09278119,0.05071273,-0.06586135,-0.036276333,0.027689798,-0.07928535,0.047329895,0.12590848,0.025837382,-0.07238144,-0.009166723,0.028946718,-0.02318424,-0.02640271,-0.06260089,0.049862657,-0.046834093,-0.11151051,0.011236363,-0.031690586,-0.07865849,-0.07123799,-0.046382762,0.052024163,0.016532201,-0.0653355,0.038235012,0.03356847,-0.009313617,-0.062531196,0.057695027,-0.022377277,0.026495414,-0.062048923,-0.042469975,0.061498944,-0.08177073,-0.05791382,-0.0066328323,-0.12773085,-0.0067044515,-0.03894731,0.15491466,-0.11871406 +2.1.1.65,"As well as licodione [1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione], the 2''-hydroxy-derivative and isoliquiritigenin can act as acceptors, but more slowly.",384,1.0,-0.0017047806,-0.14782287,-0.05892306,-0.0034050317,-0.010332115,0.0009373453,-0.00055361114,-0.0727555,0.033303082,-0.033315327,0.14112426,-0.037708867,-0.068091996,0.06460522,0.018613698,0.05158198,-0.014670398,0.03201921,-0.04250181,0.04731637,-0.03569178,0.016706709,-0.032282114,0.032669928,-0.03976911,-0.053827878,-0.002491035,-0.007410775,0.10305288,-0.10865285,0.01990814,-0.008322768,-0.05274545,-0.030325422,-0.0020229067,0.0106934775,-0.014524266,0.005903821,0.010406716,0.016863748,0.08287951,-0.109528266,0.0026536512,0.00970243,-0.09846188,-0.09772651,0.008935115,-0.018767195,0.016040565,-0.02626607,-0.008234931,0.0023654194,-0.063743,0.13656472,-0.051441286,-0.028170358,-0.11022286,0.04696625,0.025371984,-0.01900022,-0.062336516,-0.0018379266,-0.06026133,0.040231153,-0.046258334,-0.046347428,0.04417714,-0.06811966,0.009561401,-0.027106637,0.021222187,-0.07545494,0.036764357,-0.0036931722,0.021884823,0.05492419,-0.048713583,-0.048867706,0.016497081,-0.020229915,-0.006799364,-0.008127274,0.034721904,0.09215687,-0.0038465587,-0.024466472,-0.08035886,0.027241591,-0.02119675,-0.00881202,0.021441728,-0.0010624304,0.08340478,-0.048227005,0.015445612,0.06140795,0.11917963,-0.02972978,0.038647585,0.05679955,-0.06593132,0.059717137,-0.11210469,-0.048776392,-0.07556694,-0.0031437993,-0.029447062,-0.02920436,-0.010372338,-0.01959799,-0.06574474,-0.07555566,0.05617372,-0.020817403,-0.07486979,-0.015094454,0.027204094,-0.08531057,0.077310614,-0.10514917,-0.031063234,-0.021311203,0.064104386,0.020242563,0.0013818422,0.005627107,-0.029556397,2.0237313e-33,0.012506609,0.033799786,0.019492786,0.053318437,-0.017097432,0.022199752,-0.07340055,-0.006247692,-0.032009594,-0.094964854,-0.053793866,-0.023297515,-0.022930961,0.109754845,0.005751694,-0.034188546,0.005534482,0.06340097,0.100691244,-0.087246366,-0.009465179,0.089817986,-0.06544161,0.023851719,-0.04327561,0.01443641,0.06807209,0.04442044,0.036187343,-0.020249601,0.083648786,-0.00020962545,-0.031372383,0.06168957,0.0035243335,0.05372398,-0.050636403,-0.048593022,0.007052194,-0.0860847,-0.027845336,-0.012175384,-0.06402334,-0.055565204,0.036902215,0.0037171415,-0.02594969,-0.03458071,0.004341831,0.0069736955,0.07256443,0.018512882,-0.0045486656,-0.04040269,-0.033451304,-0.009994562,0.019513514,0.031144492,0.05268946,0.012867184,-0.046395037,0.063879944,-0.02591901,-0.023883972,0.005267514,-0.011664339,-0.0644238,-0.057691548,-0.026446642,-0.0020872597,-0.011706854,0.031172637,0.060931623,0.017169213,0.09286545,-0.025521405,-0.06261884,-0.025459725,0.04072993,0.02849722,-0.066278085,-0.0058624744,0.0014936968,0.15464832,-0.09104715,-0.023562873,0.0070434827,-0.014623024,0.017557904,-0.004710622,0.019260755,-0.048702255,-0.00069053704,0.061999947,0.027697336,-3.9989385e-33,0.016690886,-0.0836888,0.022832852,0.01171496,0.06033231,0.019606715,-0.00044132135,-0.007303904,0.107067466,-0.014923826,0.13681667,0.042172424,-0.027550362,-0.027832296,0.003576732,0.016999027,0.029428277,-0.009644903,-0.012494373,0.0030318336,-0.036389578,0.0045629507,-0.049666688,0.08504061,0.051355183,0.024319937,0.0916291,0.013588933,0.0013101972,0.11313969,-0.049079355,0.03353245,0.008029454,-0.011155053,-0.014733767,0.052921034,-0.09215651,0.02766931,-0.09689448,0.017092366,-0.0514096,-0.021540636,0.052215207,0.058825687,0.037178997,-0.02058277,0.03205549,0.012898152,0.03584172,0.014217777,-0.027176954,0.039433055,-0.036538817,0.009181704,0.120287165,0.07299754,0.009907602,-0.048948344,0.044542518,-0.061153103,-0.02509023,0.0012206732,0.10830428,0.019665876,0.017051874,0.037355475,-0.07491763,0.0005510488,-0.009431992,0.011576073,0.12786944,-0.051369127,0.05313824,0.017745517,0.085663386,-0.13043699,0.046931267,-0.027509943,-0.06109798,-0.020875009,-0.02120733,-0.028696824,0.00014022047,-0.03353874,-0.0015435749,-0.06731744,0.0009979503,-0.023885386,0.019904109,0.01301548,0.05927664,0.08634588,-0.006616821,0.029945632,0.046557736,-4.4591257e-08,-0.03872108,-0.05675233,0.008583353,-0.0794438,-0.05602182,-0.015409675,0.05077493,0.03153954,-0.03864659,0.027505906,0.09983228,0.05852184,0.030693937,-0.04341609,0.065232374,0.004839969,-0.05805348,0.037545342,-0.056794606,-0.08305697,-0.06365078,-0.014582687,0.02779023,-0.08074002,-0.033298627,-0.02513571,-0.019988978,-0.030447708,0.07439266,-0.009654625,0.08053117,0.047130715,0.004620898,-0.06927719,0.008314898,0.08292864,-0.005040541,-0.04832185,-0.013587851,0.08303061,0.035042867,-0.0020123292,-0.049523532,0.03720043,0.038902927,0.036397405,-0.02057503,0.065959625,-0.010888451,0.0019921192,0.043680184,-0.022468066,-0.012091162,-0.05969724,-0.058637097,0.011092729,-0.041596994,0.029780403,-0.010043977,-0.06261419,0.0017640366,0.028145988,0.1932605,0.026371555 +2.1.1.67,"Also acts, more slowly, on thiopyrimidines and aromatic thiols. Not identical with EC 2.1.1.9 thiol S-methyltransferase.",384,1.0,-0.0064121885,-0.012164718,-0.08829741,-0.010833403,0.10037042,0.03197994,-0.06803702,0.09766427,0.10628478,-0.056935873,0.06148024,-0.037634235,-0.02788757,-0.013053539,0.02499579,8.964402e-05,-0.033352576,0.01270231,0.007062394,-0.022468114,-0.0111754015,0.023072945,-0.026519675,0.025700089,0.0063934913,0.031300783,-0.016669422,0.022368604,-9.24256e-05,-0.08119799,-0.011950059,0.0091596255,0.011055791,0.0023365996,0.033497367,0.051682808,-0.026698973,0.038748257,0.026605776,-0.036500506,0.09111475,-0.057053987,-0.03970849,-0.04011438,-0.061734155,-0.055573035,0.021259954,0.04603129,-0.05158236,-0.0048354715,0.02156632,-0.03395448,-0.0061013266,0.04251165,-0.06255551,0.022468999,-0.071879275,0.04632252,-0.055474635,-0.016010448,-0.025323218,-0.018425604,0.027377058,0.029431231,0.032316,-0.011149848,0.087345995,-0.07978594,0.042783197,-0.049773708,-0.06941754,-0.0020908336,-0.01715756,0.10387099,0.047329795,-0.00470934,-0.039439745,0.0022462243,0.01961901,-0.096223384,-0.01810667,-0.005543279,-0.0179424,-0.027218014,0.01768751,-0.03242531,-0.042055402,0.027747048,-0.051782727,0.018617477,0.099245846,-0.0011339149,0.02768848,-0.020003026,-0.05368161,0.052073117,0.06209751,0.109397694,0.042355582,-0.04391284,0.03085495,0.08381112,-0.1494912,-0.014633477,0.029722836,0.02700148,0.054396685,0.026987707,-0.05642696,-0.057762723,0.049532484,-0.05198031,0.073755026,0.012519326,-0.06293182,0.066295184,0.011945998,0.00094433734,-0.013969528,-0.031217607,0.0005610739,-0.06201224,0.021199908,0.040229812,-0.04988396,0.0059458185,-0.073630236,2.2416202e-33,0.046235498,0.050216746,0.029395519,-0.043195248,0.017948346,-0.025183408,-0.10031504,0.077047065,0.005330536,-0.04196179,-0.10872848,-0.10450244,0.019693617,-0.024714516,-0.019879794,-0.085921265,-0.05068233,0.012480194,0.047180243,-0.06852768,-0.0052531487,0.036338653,-0.047007922,-0.008407243,-0.008871854,0.019520553,0.01184042,0.056213178,0.015302001,0.0057718134,-0.036085326,-0.07243299,-0.017035706,0.019621853,0.02722689,0.07182783,0.029061727,0.009429342,0.038642034,0.021133427,-0.007081255,0.060175136,-0.010437112,-0.07535626,-0.0023228005,-0.05720362,-0.06164791,0.060149156,0.020780355,0.023568165,0.01786485,-0.108664885,0.10872506,-0.018605383,0.014407579,-0.03810448,0.007154074,-0.020986533,-0.034431778,0.0803108,0.03513569,0.025719535,-0.052430984,-0.0054688226,-0.033610698,0.008129007,-0.07844015,0.025706392,-0.058366828,0.046215102,0.000102579106,0.063516356,0.12332285,-0.05085953,0.12828861,-0.022234716,-0.08794457,-0.0015649414,0.04462256,0.05676324,-0.025912361,0.008411081,-0.020066367,-0.022137227,-0.032229435,-0.030883774,0.030414306,-0.03932021,0.0068686972,0.03908095,0.005359317,-0.048042603,-0.043303873,0.036736343,0.04280173,-2.8830612e-33,-0.010010545,-0.0240034,0.045253832,0.002197866,-0.009159625,0.057456564,0.010713901,0.051401235,0.006431469,-0.024539595,0.14948136,-0.013998744,-0.030139515,-0.099421345,0.022175457,-0.03558558,0.02594692,0.06136582,0.020654973,0.0066216667,-0.021298608,-0.003191284,-0.07255341,0.064467914,0.007670372,0.016785357,-0.050041858,0.08124438,0.08601463,0.069531634,-0.025690285,0.009242298,-0.11855021,-0.027016988,-0.017146349,0.046474077,-0.04843223,0.014509874,-0.01964018,-0.0029712163,0.015852349,-0.031826068,0.047106843,0.06728431,0.08381231,0.121211156,-0.04263448,-0.0023664567,-0.018141748,-0.07159122,0.034138657,0.03540538,-0.054986443,0.13593993,0.03904644,0.04491347,-0.011615803,0.0027204228,-0.05555529,-0.0681483,-0.08287931,-0.030549027,-0.068938844,-0.056556802,0.015793618,-0.024145577,-0.103168525,0.0745949,0.0959362,0.013629206,0.08999709,-0.047735546,-0.034597453,-0.020165293,-0.046970695,-0.09227267,-0.03331052,-0.07240732,-0.017943801,-0.028392784,0.032833748,-0.009061945,-0.0073799347,-0.10885074,-0.06395723,0.042168126,0.012522697,0.05786799,-0.07409267,0.06266938,-0.02731178,0.05299233,-0.023745313,0.07754192,-0.022890242,-3.142896e-08,0.0052101407,-0.09790905,0.0547661,-0.016272476,0.008290886,0.054495286,-0.014316491,0.10968804,0.052644625,-0.059502635,-0.039771486,0.02374849,0.06539836,-0.02021569,0.08000075,0.024329036,-0.0058689835,0.031920522,0.01090327,-0.035736162,-0.08704954,-0.0051501836,-0.035941433,-0.0398228,-0.02612209,0.009111331,0.0024320597,-0.004748944,0.031076735,-0.0900161,0.075454995,0.011179218,-0.0008198281,0.04975217,-0.022327906,0.008723733,-0.04199949,-0.032383233,0.034503214,0.03228433,-0.012997024,-0.0054673445,-0.14519025,0.07900071,0.07851971,-0.036381204,0.06539462,0.090535454,-0.06682865,-0.061627492,0.0013821484,-0.061636556,-0.0059831305,-0.08374765,-0.005528462,-0.024682175,0.0069821524,-0.032402247,0.05318907,0.0012104427,0.07425207,0.030999158,0.14802921,0.04109688 +2.1.1.68,"3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly.",384,0.99999994,0.021211585,-0.11309278,-0.07786446,-0.009354157,0.04503711,0.019103572,-0.027862797,-0.028758002,0.045269497,-0.03176644,0.08801879,-0.011001431,-0.076043345,0.051254623,-0.016488025,0.10016029,-0.044615146,0.08012194,-0.05121297,0.054499194,-0.079822175,-0.047422502,0.025637206,-0.004308481,-0.027530376,0.027988382,0.0010495,0.0028310886,0.018463742,-0.08349679,-0.00066688453,0.048711404,-0.008309599,-0.005159455,-0.017104095,0.007344267,-0.06009124,-0.037609827,0.0037763747,0.040673282,0.0023214782,-0.083957545,0.011434921,0.028040897,-0.04944642,-0.072164066,0.024141375,0.055522505,0.03401896,-0.09627363,-0.024479294,0.018387798,0.0162374,0.046960905,-0.049619965,0.0014094835,-0.105615124,0.042847745,-0.02574113,0.04208299,-0.021894818,-0.0054951217,-0.0871715,0.0013983179,0.01330002,0.004851565,-0.004124216,-0.05208563,0.049800336,0.08099812,-0.017051553,-0.017135149,0.007907251,-0.034562368,0.041924063,0.035677847,-0.0074053006,-0.011196636,0.084570296,-0.021199277,-0.04332123,0.02219846,0.056393396,0.0979679,0.05265038,0.004902382,-0.07121706,0.047071487,-0.07432056,0.056713678,0.04813272,0.023654053,0.042329624,-0.020724934,-0.020156048,0.020627677,0.116462335,-0.016403975,0.05578787,0.013396411,-0.01995728,0.02409951,-0.09119154,-0.06556223,-0.079131566,0.009871523,0.014518191,0.015055272,-0.030334925,-0.0025582951,-0.028648179,-0.12537263,0.029395405,-0.013133083,-0.08826282,0.053078562,0.08050854,-0.08480548,0.011014035,-0.060878668,-0.056543123,0.01425752,0.04003665,-0.05849478,-0.05765761,0.056246962,-0.0028074337,2.6638612e-33,0.015994642,0.04450084,-0.029511008,0.009429756,0.027918592,0.026645169,-0.09182669,0.046984974,-0.03421425,-0.04105433,-0.0859768,-0.04254973,0.0150534175,0.005076185,-0.025760606,-0.05887424,-0.049460217,0.009681559,0.06687214,-0.035669945,0.027802521,0.058829773,-0.056739017,0.023775946,-0.032160733,-0.0052718916,-0.027292473,0.0015098245,0.056635555,-0.02000902,0.052900806,0.008358534,-0.06936368,0.0027414002,-0.07438448,0.05474401,-0.031618588,-0.021020409,0.048883405,-0.044659637,-0.005102528,0.037924066,-0.04235832,0.0021031578,0.062570944,-0.0073597943,-0.0140243545,0.013096178,-0.022565778,0.039508466,0.079341754,0.026669944,-0.01763422,-0.040506404,-0.03764315,-0.019837145,0.01551955,0.04534497,0.032951746,0.053924523,-0.029292047,0.07422228,0.013059105,-0.01962287,-0.023358054,0.0061549037,-0.0321156,-0.028700486,0.0052011353,0.007905851,-0.00990662,-0.024967726,0.033932313,0.0080961855,0.06760853,-0.05858325,-0.053897295,-0.01683649,0.0562981,-0.035661817,-0.034485552,-0.012079111,0.0371802,0.070494466,-0.076319896,-0.016511077,-0.00037442974,-0.05498446,0.01875337,0.016373074,-0.0001694685,-0.057056237,0.0019513996,-0.0024184976,0.07053991,-3.7504654e-33,0.09708507,-0.104113996,0.043668088,0.028241377,0.037248302,0.058239944,-0.0013349823,-0.038891185,0.1440222,0.028411482,0.16022645,0.024196975,0.073540956,-0.007467614,0.011437372,0.031510964,-0.025979485,0.06270938,0.015246858,-0.0047868574,0.0071248026,0.05615695,-0.0653897,0.096987665,-0.014160974,0.026753783,0.037480287,-0.08196584,0.085479885,0.06731907,-0.0065353652,-0.027151315,-0.01619503,-0.027419625,0.063337,0.04459209,-0.104816966,0.017238878,-0.088979445,0.042476058,-0.031238992,-0.018924952,-0.0028345615,0.06943614,0.01627241,-0.002207917,-0.011613812,-0.005655865,-0.042342164,-0.0014147275,0.027940134,0.036491085,-0.05768291,0.03778206,0.088319264,0.10055169,0.06728336,-0.13636175,0.008523824,0.0198854,-0.07247824,-0.038083453,0.06593106,-0.041478746,0.039701216,0.01762147,-0.054046698,0.06790055,0.08880787,-0.084333174,0.12686044,-0.0062669287,0.023062408,0.10700324,0.024491979,-0.07012673,0.052312322,-0.0437161,-0.026416034,-0.0059086243,-0.060639452,0.023728706,0.05853591,-0.05145754,-0.030812886,-0.09825634,0.03982325,0.0028599594,-0.056577835,0.085945316,0.095711574,0.04142094,0.086943164,0.05269209,0.07014055,-2.9510318e-08,-0.0048232004,-0.04982557,0.027975243,-0.05983965,-0.08546458,-0.013320136,0.07190245,0.032672103,-0.038039465,-0.030213704,0.062383603,0.058867484,0.04838565,0.018118089,0.081855714,0.0039155055,-0.058518834,-0.07764637,-0.06422658,-0.020161137,-0.117571786,0.028617565,0.0094047915,-0.085479945,-0.026782991,-0.01880043,-0.034194265,0.0008205874,-0.013775404,0.0045509106,0.022742262,0.037667364,-0.016776863,-0.033402134,-0.011419363,0.045343272,-0.009403161,-0.100705236,-0.058181744,0.021243526,-0.007674697,-0.14715302,-0.07732829,0.0051344866,-0.020946452,-0.039491177,-0.03544654,-0.0027097499,-0.029901275,0.036739122,0.05221171,0.040272366,0.042880844,-0.021599986,-0.04497784,0.038273863,-0.06504203,-0.021857318,0.00816779,-0.11622344,-0.0052391756,-0.016015278,0.14123285,0.02739186 +2.1.1.69,"Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin [3], but has little activity on non-coumarin phenols [1]. Caffeate, 5-hydroxyferulate and daphnetin are not substrates [4]. Cu2+, Zn2+ and Co2+ cause enzyme inhibition [4]. (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase)",384,1.0,-0.06288811,-0.010863583,-0.08342899,0.0925922,0.12659387,0.074915275,-0.06665093,0.08957272,0.029862525,-0.011125256,-0.027500385,-0.02852359,-0.06555519,-0.030532721,-0.04000254,0.13469201,-0.00273142,0.046891183,-0.004185461,-0.009368339,-0.012110443,-0.043172237,-0.011752538,-0.007563682,0.0046947002,0.037372388,-0.035509817,0.016100496,-0.028509358,0.036081333,0.02328851,0.025987402,-0.06357419,0.050065566,-0.03026264,0.029742176,-0.030118346,-0.13381925,-0.016588986,0.052866034,-0.0012499451,-0.013253403,-0.095954776,-0.04011115,0.00059731666,-0.115136184,-0.014984485,0.024757257,0.02135363,0.044165917,-0.0277347,-0.057396617,-0.063181736,0.0022074885,0.0074701174,-0.012688937,-0.047312364,-0.04795613,0.020756705,0.08597237,0.008337298,-0.0720563,-0.058202073,-8.7667206e-05,0.018673815,0.035046853,-0.03093103,-0.03278158,-0.010563656,-0.023990206,-0.07972141,-0.022980062,-0.007909765,0.0359795,-0.047375295,0.064214766,0.01232309,-0.032977093,0.034366,-0.013564888,0.010053027,0.07605937,0.015321447,0.062565334,0.028265923,0.019576596,0.006714659,0.030707628,-0.016740253,0.041355688,-0.019318616,0.047050465,-0.02655291,-0.034000713,-0.026093002,0.0048552407,-0.0042650304,0.016531229,-0.027917402,-0.014094625,-0.06947264,0.023940004,-0.030660827,-0.1543825,-0.022258967,-0.037885286,0.025921678,0.06338277,-0.0077995467,-0.015609521,-0.0140181985,0.0013344099,-0.08443957,0.0065877577,-0.0057010297,0.06471502,-0.0019416946,-0.095589526,-0.04877191,-0.02541985,0.0029227743,8.523635e-05,0.045869846,0.0081963865,-0.07819582,-0.020076524,0.08808163,2.3898544e-33,0.01734559,0.06256645,0.049225193,-0.0049454616,0.051073477,0.044218503,-0.069843866,-0.014435106,0.027589966,-0.06452463,-0.07893774,0.002387381,0.014180651,0.093797326,0.053339228,-0.0074008303,0.049718793,-0.0059266584,0.07747413,-0.021518894,0.07823034,0.056397248,-0.06632198,0.020631438,-0.081167065,0.15069932,-0.07131642,0.054193642,0.03463023,-0.027397828,-0.031101381,0.008266037,0.0039278446,-0.00667071,0.02503662,0.07528455,-0.0471946,-0.020049877,-0.04178469,0.03465015,0.05408545,-0.030197414,-0.0356182,0.009278962,0.056433532,-0.062101353,-0.11927313,-0.018847631,-0.059474647,0.03191127,-0.009686023,0.04261869,0.028272482,0.08695472,-0.0010921735,-0.016107464,-0.018431818,0.018289058,0.06021594,0.035864234,0.05295178,-0.051405493,0.04825492,0.006707839,0.021599647,0.04611406,-0.011501555,-0.01846758,-0.07215745,-0.011958652,0.007991675,0.03935678,0.055862628,0.06683586,0.10406343,-0.009052486,-0.014965689,0.051622156,-0.04712991,0.05414155,-0.038269825,-0.011749884,0.036632635,-0.005549027,-0.072418846,0.0042171683,-0.0057166917,0.025154999,-0.061187092,-0.017083285,0.021030428,-0.06277339,-0.0066597797,0.03260663,-0.035403837,-4.3864358e-33,0.064244874,-0.078844726,0.006834132,-0.11934386,-0.09658699,0.100559436,0.024284298,-0.07178159,-0.06260241,0.02433454,0.12042701,-0.032223016,-0.016704937,-0.02321763,-0.052065715,-0.044278633,-0.005676095,0.061404377,-0.053277027,0.044118475,0.016926812,0.114963725,0.050126992,0.057106096,0.026257396,0.017758396,0.07162421,-0.060970582,0.007732511,0.09403548,-0.025440602,0.042837795,0.0038889325,-0.06674205,0.029446136,0.039294098,-0.006568672,-0.033248797,-0.01556675,0.06766454,0.016730113,-0.08075999,-0.073172934,0.029931948,0.061236087,0.07169012,-0.125709,-0.04699866,-0.04515177,0.017935002,0.051682647,0.084104985,-0.0392452,0.04378599,0.061485063,-0.027014637,0.010059358,-0.0944557,0.060283143,-0.043627407,-0.0637926,0.004108166,-0.014121438,0.014794509,0.06682878,0.08997097,-0.019496616,0.0360919,0.0047277575,-0.0037807592,0.05476256,-0.025724672,0.038367726,0.03518999,-0.07926223,-0.039437804,0.027787767,0.06452584,-0.052531675,-0.030968104,-0.06759237,-0.09015246,0.0153227635,-0.025162831,-0.07686164,-0.048921265,0.00067530846,0.010499165,-0.053311527,0.05524787,-0.053517032,-0.02917001,-0.09035481,0.046559267,0.029253563,-4.114078e-08,0.012674926,-0.049126588,0.09919772,-0.013470322,0.011232302,0.06331991,-0.02213587,0.017173247,0.019894848,0.043596156,-0.0730641,0.07717997,0.023826769,-0.01901375,-0.075940944,0.027444221,0.09015893,0.019154744,0.04641693,-0.057008877,-0.11421513,-0.008525639,0.032959227,-0.06354415,0.033744823,-0.08114164,0.051259447,0.09155673,0.0021272763,1.1405778e-06,0.009399037,0.026001757,-0.01040582,0.014370864,-0.06329922,0.058869943,0.062831484,-0.01931748,-0.014658707,0.054257058,-0.12210785,0.012296926,-0.067180276,-0.0057095625,0.00973581,-0.002052695,0.09468886,0.026608959,0.044270422,-0.002723648,-0.0025019771,-0.0052480455,-0.010123038,-0.087475516,-0.1017004,0.023192694,0.03825942,-0.05179072,-0.06583624,-0.00560654,-0.020496408,-0.06403992,0.080234334,0.06284452 +2.1.1.70,"Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase). ",384,1.0,0.004408578,0.02255091,-0.051847193,0.019949801,0.090065524,0.04718535,0.012614393,0.07100466,-0.0018438835,-0.037047155,0.029071698,-0.008642267,-0.08925782,-0.03716579,0.017165828,0.12517014,-0.032748844,0.07601379,-0.02229143,0.0111950515,-0.00033737926,-0.03975198,0.0074963095,0.02954884,-0.043497156,0.036909323,-0.008749505,0.028150503,-0.0006752902,0.030451154,-0.011988315,0.05887193,-0.044479,0.0037099202,-0.027167208,0.015890352,0.008274076,-0.106676035,-0.0037869266,0.019309245,0.010359754,-0.03705938,-0.10408987,-0.02727628,-0.028335227,-0.12828481,0.010590071,-0.00054828025,-0.0056175524,0.026181022,0.014236123,0.017775094,-0.027454473,0.052016497,-0.019422943,0.05441336,-0.08165083,-0.04509792,9.819636e-06,0.05448963,-0.039374717,0.020350963,-0.024374556,0.03260325,-0.00069781026,-0.011908782,-0.03254676,-0.02232504,0.011846611,-0.036196925,-0.10513406,-0.02989975,0.048838984,0.0027870345,-0.10902475,0.07543451,0.038692214,-0.030889038,0.023282586,-0.006114541,0.023005499,0.07549551,0.033219073,0.058655526,0.016464464,-0.013998011,-0.022413287,0.04055857,-0.012578653,0.053074077,-0.03705313,0.063421495,0.017692393,-0.049933564,0.013742161,0.010610422,0.06500065,0.000101565965,-0.0022884007,-0.009485367,-0.021177819,0.048148017,-0.03581119,-0.130158,-0.010638482,-0.059062693,-0.025623199,0.0701756,-0.0013860277,-0.054910004,-0.044908565,-0.056418497,-0.04052351,-0.019984264,-0.005642867,0.05474959,0.017155487,-0.0488305,-0.04338238,-0.05922169,0.028137336,-0.020860218,0.0061453036,0.039543375,-0.028501587,-0.04088038,0.057786144,2.5457259e-33,-0.0026547702,0.14986128,0.0603404,-0.032393735,-0.00059930084,0.03710112,-0.0073594167,0.031307366,-0.0061586187,-0.0661868,-0.052168533,0.019669384,0.028504083,0.075860575,0.025186036,-0.045110196,-0.0015355494,0.014215166,0.091647364,0.00837613,0.043003004,0.058428433,-0.049331952,0.037015818,-0.13917306,0.14914642,-0.039595302,0.043482177,-0.0046723536,-0.029680867,-0.022473097,0.02167361,0.01591347,0.05154776,-0.003736687,0.10558644,-0.036533765,-0.041889153,0.0065295217,0.04756651,-0.010139529,-0.02614473,6.2711246e-05,-0.011631256,0.06617477,-0.050692704,-0.13273567,-0.06589922,-0.04435668,0.039045278,-0.009421414,-0.00047012934,0.008320323,0.060622662,0.022145592,-0.034579374,-0.02419279,0.015651967,0.0077626444,0.04824946,0.02306957,-0.027290778,0.0006944518,0.03186334,0.0050945655,0.05370112,0.03035941,-0.050505217,-0.09045546,0.00721876,-0.026816892,0.06577171,0.06733905,0.044961046,0.14952233,0.027173197,-0.018541746,0.059390213,-0.044079717,0.06115629,-0.019829141,-0.01925326,0.008309887,-0.019963022,-0.02320857,-0.0026157387,-0.031370208,0.044737846,-0.036184672,0.00075936166,0.00030753604,-0.14161529,-0.007427493,0.031158822,-0.044172205,-3.6093683e-33,0.00480192,-0.025360836,-0.018140212,-0.07057976,-0.04808536,0.07661939,0.03255763,-0.06700192,-0.048908565,0.004348137,0.0796536,0.011583948,-0.0086814575,-0.026966726,-0.06713136,0.013531233,0.087198235,0.021708496,-0.08656092,0.024636906,0.026603583,0.102768146,0.02684628,0.06964755,0.059774667,-0.009027746,0.12574516,-0.08676079,0.08454707,0.028609699,-0.0367276,-0.011364193,0.0045832098,-0.035567597,0.054097082,0.0038700234,-0.0387885,0.023599865,-0.038506076,0.045215752,-0.0030253755,-0.104467586,-0.020591935,0.05272982,0.02675468,0.10365259,-0.10881501,-0.032137983,0.020527357,0.06399229,0.0140277315,0.10106957,-0.06600266,0.039044697,0.041910775,-0.024846645,-0.01698816,-0.09708026,0.0024557651,-0.018508261,-0.0307518,-0.020997323,0.025301127,-0.0018338681,0.040346622,0.025509939,0.0043076333,0.037160587,-0.059489552,-0.028819343,0.11224464,-0.06569051,0.024831932,0.06983231,-0.085786045,-0.075704135,0.03524883,-0.008508227,-0.03719309,-0.057649147,0.01075701,-0.1099575,0.0667857,-0.03295279,-0.023488332,0.0071144775,-0.025660561,0.023898715,-0.055415895,-0.022331322,0.00013967263,0.029058859,-0.07723868,-0.022515325,0.054916054,-4.0179117e-08,0.037348058,-0.09241156,0.081838794,-0.033832688,-0.0024207355,0.10633439,-0.018374152,-0.0007953524,0.05516383,0.04634445,-0.05249279,0.06793531,0.054386005,0.0016583657,-0.10154032,-0.005777642,0.09911635,0.044092704,0.021000592,-0.08931558,-0.14153992,-0.024691692,-0.001370724,-0.07529507,0.030793771,-0.09960527,0.023954866,0.04394891,0.05797315,-0.026427537,-0.00577105,0.025497083,0.005749368,0.044013344,-0.016745845,0.07456638,0.04980993,-0.021002248,-0.013754137,-0.0327051,-0.12104969,-0.010617082,-0.042256616,0.0044431104,0.0085945865,-0.01066508,0.11704595,-0.025447348,0.03213815,-0.012688063,0.022833262,-0.016236255,0.00613104,-0.10977473,-0.09667476,0.024630534,0.046063535,-0.059921984,-0.026450276,-0.017109884,-0.022767443,-0.019026883,0.07950351,0.068252504 +2.1.1.71,"The enzyme also catalyses the transfer of a further methyl group, producing phosphatidylcholine.",384,1.0,-0.0038950064,-0.026536085,-0.10108498,0.007300121,0.057301722,0.022773996,-0.013268506,0.0044491836,0.004107322,-0.01066884,0.06591781,-0.037079014,-0.055805378,-0.008140329,-0.014281573,0.09382056,-0.07002558,-0.0175448,-0.039405026,-0.033679586,0.10407521,-0.0067159445,-0.031692777,0.019660065,-0.055706143,0.029555442,0.0036499393,-0.08586345,0.030680448,-0.05271277,-0.034761377,-0.008254999,0.0032482143,-0.05041677,-0.022301866,0.10889318,-0.031261597,-0.020497484,-0.016100803,-0.0015670788,0.07677899,0.02447538,-0.0047426685,-0.013377895,-0.08367671,-0.004470018,0.018094018,0.030505067,0.017836291,-0.01963916,-0.041484393,-0.09113457,-0.06318546,0.03142747,-0.052689243,0.13029651,-0.052499082,0.024186254,-0.056817498,0.0063342727,-0.037558377,0.022579173,-0.038887125,0.045178212,0.050452597,-0.06639374,0.025766352,-0.059423607,0.028217224,-0.016075272,-0.07656896,-0.084448464,-0.024110926,0.006701908,0.091843225,0.018699167,0.048206434,-0.002428795,0.085910104,-0.07675625,0.048740994,0.0047396827,-0.031190159,0.057076376,0.0790381,0.059358742,-0.010287801,-0.01863486,0.053196643,0.046887003,-0.0048461785,-0.051167104,-0.064582735,-0.014510103,-0.08691966,0.035142448,0.019413337,0.051699687,0.040914148,-0.010248738,0.036393188,0.047751516,-0.073816,-0.0622173,-0.039894,0.032635175,0.051338628,0.007234764,-0.034080766,0.02958708,0.007161555,0.077786505,0.078245595,-0.019682674,0.038692925,0.084648795,0.028369714,-0.030149173,-0.0339006,-0.03671504,0.006448051,-0.028435491,0.006635514,-0.00070118235,-0.074926,0.013065968,-0.14009526,-5.8940145e-34,0.038363814,0.030301284,-0.0031206952,-0.067166515,0.003531092,-0.028430251,-0.038839046,0.014453175,-0.019366303,-0.034132984,-0.06449907,-0.15349247,0.034115955,0.073597446,-0.05733427,-0.052437592,-0.027366823,0.03700236,0.066539995,-0.037725575,-0.04249363,0.059008155,-0.058557507,-0.007609192,0.034759093,0.039382998,-0.035176963,-0.0024522475,0.03844653,-0.0053405417,0.04215247,-0.08057689,-0.15839037,0.01259073,-0.023185432,0.10189047,0.01990905,-0.06849672,0.04209911,0.067693315,0.006141931,-0.011032166,-0.047825925,0.015127944,0.013673303,-0.04085772,-0.097265586,0.07977835,0.088051684,0.00436879,0.0027712695,-0.07903458,0.114179924,-0.034045283,-0.070425704,-0.0018241231,-0.0047335206,-0.05437079,-0.004430305,0.033950686,-0.022524638,0.07279283,-0.07561588,0.06939868,0.03899731,7.470784e-05,-0.014112429,-0.043244302,-0.0076480103,0.05891108,-0.04579644,-0.008156896,0.013966506,0.01787629,0.01840054,-0.06563971,-0.054204173,-0.029631348,0.02410056,0.073235415,0.08507609,0.009026375,0.026421154,0.0007208569,-0.075430535,0.025255173,-0.0026588826,-0.03065762,-0.03376321,0.020050656,0.010460608,-0.047506366,0.015751682,0.040368106,-0.021824382,-1.3190873e-33,0.056790195,-0.06105167,0.06861381,-0.05215134,-0.02312624,0.066507116,0.028256755,-0.01861336,0.016181594,-0.02801915,0.034807492,-0.005310323,0.03998518,0.01970685,0.030224303,-0.00056817126,-0.08632334,0.039430734,0.049010236,-0.02690117,-0.00966544,0.09918874,-0.020453937,0.14951922,0.030196492,-0.04711455,-0.06738828,0.10387938,0.046365466,0.072606325,-0.010552388,-0.060896978,-0.055788744,-0.016184073,-0.005357137,0.10576683,-0.055668924,-0.0039636693,-0.033122774,0.060684238,-0.022984564,-0.023469683,0.11972428,0.0005363786,0.02260399,0.07263042,-0.060819715,0.012701565,-0.052737113,0.01589726,0.051321,0.06659256,-0.022637969,0.04349785,0.027983343,0.09905552,0.016053185,-0.008584543,-0.017806869,-0.107041486,-0.062447958,-0.055439953,-0.051605746,-0.033765197,0.039519057,0.0521401,0.03802235,-0.026827792,0.005772282,-0.01318634,0.06705341,0.08082458,0.023221357,0.0020254361,-0.013553881,-0.015926432,-0.057241715,-0.04446693,-0.023727706,0.0006058259,0.055813693,0.021059433,0.09759465,-0.09019896,0.0005566518,-0.02038758,0.009996263,0.07315282,-0.010731002,0.000798208,-0.010181395,-0.048762575,-0.03825188,0.01882293,0.054281045,-2.4968019e-08,0.06690762,-0.06444436,0.021985304,-0.06758008,-0.04878235,0.04941845,0.02856972,-0.03514705,-0.02733858,-0.011396087,-0.045840457,0.049367797,0.01648302,0.100401886,0.03946019,0.01313691,-0.05990789,0.041852303,-0.0056493487,-0.082045615,-0.046705652,0.0065184096,-0.07786363,0.03583425,0.037554447,-0.008186926,0.03272133,0.09323562,-0.02514886,-0.0059610507,0.022778228,0.04517375,-0.02875825,-0.0033443312,-0.043750834,0.04417264,-0.0027249216,-0.038397536,-0.0146504,0.07797366,0.017546078,0.012951798,-0.007627287,0.020819021,-0.01175046,-0.012167216,0.021422513,0.015108046,0.031593643,0.023692561,0.0725452,-0.0395555,0.0066513387,-0.056901224,-0.10777031,-0.062934235,-0.07900298,-0.040818367,-0.0026704418,-0.04167805,0.02322015,0.06960794,0.22157823,-0.06794672 +2.1.1.72,"This is a large group of enzymes, most of which form so-called 'restriction-modification systems' with nucleases that possess similar site specificity [the nucleases are listed as either EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease)]. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html.",384,1.0,-0.035658613,-0.040462267,-0.059395056,-0.07299268,0.08456541,-0.0009380046,-0.061564,0.007012774,-0.047670566,-0.03684872,0.017268136,-0.044882167,-0.04779538,0.041935787,-0.07851368,0.056414437,-0.082691096,0.023808416,0.021303149,-0.089507625,0.06737477,0.069367886,-0.0038057119,0.0060075363,0.039921828,-0.028498858,0.01761555,-0.0008608106,-0.026269287,-0.12306035,-0.0063616442,-0.05413427,0.054359917,-0.0530738,0.122844115,0.051172435,-0.09733603,-0.024598628,0.026304891,0.02097124,0.02583535,0.021771649,0.02147859,-0.011556728,-0.066507034,-0.00024307019,-0.0440611,-0.0029980524,-0.029676672,0.014751552,0.020927299,-0.051043514,-0.060229354,0.06755322,0.07440348,-0.038065642,0.008650337,0.008246902,-0.030768953,0.02676203,0.04744105,-0.02308771,0.008335828,-0.06948855,0.00047013507,0.07673623,0.029820802,-0.014580039,0.011412265,-0.107192114,-0.016645199,-0.06870552,-0.056213774,0.04816919,0.008398062,0.04006613,-0.00069991424,-0.026781993,-0.0020267111,-0.018277729,-0.011224917,-0.028062494,0.065018,0.025706958,0.020203866,-0.046621833,-0.016061345,0.024026984,0.07812097,0.073465325,0.00075890706,-0.0454385,0.013905212,-0.058063637,0.001527663,0.05599805,-0.00078648084,0.066640675,0.0489988,-0.049367085,0.027382655,0.015346458,-0.01005613,-0.04401136,-0.029141441,0.019794608,0.033563457,0.034234248,0.015063615,-0.0087546,-0.015231313,0.053237215,0.058559533,-0.05131075,-0.059796955,0.05327705,0.055381294,-0.027407361,0.013313061,0.005426912,0.06966741,-0.0030337549,0.14788055,0.010960639,0.008573615,0.062501766,-0.19130982,3.7575408e-33,0.04962872,0.056688737,-0.033614904,0.007977153,0.023444327,-0.0018555252,-0.09195013,0.05373035,-0.11151052,-0.019365411,-0.043995373,-0.04487327,0.069888294,-0.033111025,-0.0140993325,-0.07599068,0.03170578,-0.009865846,-0.020214992,0.0045282296,-0.02867515,0.06521271,-0.06779738,0.077984914,0.0014810502,0.042861216,-0.07435259,0.051164072,0.10202003,-0.015207784,0.011962673,-0.09795193,-0.0632392,0.03746878,0.060762804,0.033447452,-0.02686391,-0.04902773,0.036970828,0.057205603,0.044924308,-0.0030269597,-0.02216312,-0.049508143,0.07324703,-0.04762264,-0.06474896,0.076128356,-0.005388941,0.013374768,-0.014530411,-0.022202706,0.062004767,-0.07800352,-0.03087817,-0.042765163,-0.06424115,0.022293232,0.0885968,0.06332497,0.029925615,0.061762694,-0.033784382,-0.030052045,0.027845813,-0.011044667,-0.06458267,-0.07274522,0.019996729,0.06705531,-0.072091244,-0.015528235,0.06382033,0.024442736,0.018894263,-0.042483922,-0.048489552,0.032363445,-0.024235982,-0.021147132,-0.020896671,0.010176052,0.037073303,-0.01919475,-0.025910204,-0.096286155,-0.083079465,-0.02707923,-0.060112227,1.5833593e-05,0.04205586,-0.052507002,-0.084902614,-0.0026693484,0.011234256,-4.369051e-33,0.007862778,-0.07084803,0.019044098,-0.1290739,-0.03082295,0.051887248,0.014849515,-0.0012835067,0.050506745,-0.04365002,0.042090494,-0.03892748,0.021545878,-0.084779784,-0.05552871,0.020440763,-0.057115667,0.056690123,0.022438196,0.007950277,-0.019185849,0.09357176,-0.028660165,0.050315138,0.020929271,0.043435548,-0.049497057,0.07813858,0.12749988,0.0207319,-0.15560913,0.026799329,0.017628241,0.055487365,-0.044476327,0.019287856,-0.052694753,0.02078673,0.013780928,-0.0014345375,0.024385383,0.044291712,-0.008517563,0.08369408,-0.008853378,0.10290574,-0.087120414,0.05465048,0.024991792,-0.032097906,-0.0152951265,-0.032025475,-0.015329921,-0.024460461,0.02463782,0.010447449,0.043260142,-0.013905818,0.0022648645,-0.0010647174,-0.0025504637,-0.040643442,-0.0007883307,0.049207367,0.040177107,0.08709217,-0.024311393,0.030496068,-0.050110307,-0.011271168,0.07611546,-0.009660829,0.017862216,-0.05512604,-0.03190132,-0.05103942,-0.06591202,0.028939124,0.0016528763,-0.08898592,-0.0018427492,0.007355837,0.020145366,-0.026924511,0.092527725,-0.020362146,-0.01379728,0.10542056,-0.00341246,0.013190711,-0.078067146,-0.011773258,-0.11487507,0.09736126,0.050317794,-4.769254e-08,0.113957405,-0.06958883,0.023941929,-0.037904814,0.12085999,0.065519735,0.011985818,0.013045605,0.022582054,0.028524822,-0.030349705,0.07746962,0.009279807,-0.017815646,0.08485311,0.024842987,-0.031779192,0.072504334,-0.027306162,0.024991468,-0.00814885,0.01799272,-0.06264628,0.013401328,-0.009505713,-0.050544396,0.04685943,0.04322857,0.0044285026,-0.04892043,-0.0032393541,0.008278094,0.031467177,-0.053972956,-0.042501934,0.031668223,-0.07157906,-0.0261554,-0.049576264,0.05075328,-0.028883751,-0.08261342,-0.039878517,0.031951446,0.007487,-0.01701966,-0.009765514,0.005801148,0.015630355,0.020001171,0.03499666,-0.010650422,0.05337578,-0.013120258,-0.09926399,0.09299929,0.0046993024,-0.04829686,0.017575754,-0.023809057,0.031072216,-0.0038094602,0.20588483,0.0017906704 +2.1.1.74,"A flavoprotein (FAD). Up to 25% of the bases in mature tRNA are post-translationally modified or hypermodified. One almost universal post-translational modification is the conversion of U54 into ribothymidine in the TPsiC loop, and this modification is found in most species studied to date [2]. Unlike this enzyme, which uses 5,10-methylenetetrahydrofolate and NAD(P)H to supply the atoms for methylation of U54, EC 2.1.1.35, tRNA (uracil54-C5)-methyltransferase, uses S-adenosyl-L-methionine.",384,1.0,0.012804229,-0.013650691,-0.13453917,-0.06621108,0.014048212,-0.0060506472,-0.035693996,-0.0034554717,0.019312741,-0.007244855,0.025375597,0.04227942,-0.090786874,-0.0015150611,-0.08337115,0.031176113,-0.06700301,0.018684855,0.02988496,-0.0010430568,0.013902304,0.09406701,-0.009021627,-0.008951716,0.04845008,-0.008948704,0.01151058,-0.033921108,0.002748162,-0.046842873,-0.040610816,0.01168536,0.038259897,-0.05713974,-0.048471704,0.08204738,-0.091882594,-0.007978867,0.05979875,0.0017788352,0.057116207,-0.04516205,0.025074657,0.025517302,0.02341702,-0.030991346,-0.019108012,0.09343673,-0.033613384,0.11529288,-0.015236135,-0.0009430948,-0.059972372,-0.009802334,0.028449666,0.04648866,-0.0025516744,-0.023062563,-0.0037939937,-0.067776,0.0083902655,-0.0010305374,0.04569208,-0.034534544,0.09482032,-0.07416471,0.0024649156,-0.026666567,0.09605196,-0.058634777,-0.053639974,0.004949433,-0.018741528,0.085228086,-0.03722665,0.042768262,0.0027492256,0.0009918304,0.0776929,0.021284865,0.06546938,-0.02491301,0.04340405,0.009716923,0.05456898,0.015416068,-0.047615,0.061433744,-0.0007579873,0.043206263,0.030406171,0.026994575,-0.0016074902,-0.028231684,-0.084202476,0.072834514,0.0139843635,0.040541057,-0.04232866,-0.03763041,0.013178085,0.018123308,-0.046957836,-0.04193075,-0.081703305,-0.04223845,0.016271252,0.054391813,-0.04498234,-0.017121205,0.014695317,0.0045147194,-0.0004728143,-0.0776268,0.03357106,0.005491436,0.012280295,-0.057490762,0.02240964,-0.06973795,-0.08581224,0.10909137,0.056108758,0.06433934,-0.015402862,-0.024296401,-0.11222035,2.61966e-33,0.07760196,0.058959283,-0.0016577838,0.030294754,0.03876534,-0.0059933555,-0.036784805,-0.038653255,-0.04270344,-0.056204937,-0.09377956,-0.058207057,0.02053468,-0.06417747,0.009841507,-0.022782212,-0.03480589,-0.00038236094,0.06711788,-0.0737609,0.0076837987,0.09563198,-0.041791204,0.048988536,0.029996596,0.033996046,-0.035315275,-0.011154471,0.044898886,-0.0030211215,-0.06898469,1.9561452e-05,-0.0796649,-0.015197383,0.067192644,0.0023425105,-0.044743296,-0.037670862,-0.0897936,0.092692606,0.09789635,0.021341233,-0.02156747,0.0142819,0.046852246,0.029456357,-0.043390505,0.08382282,-0.052839242,0.016216772,0.008253493,-0.016173357,0.053276338,0.004641567,-0.097474314,0.004521691,-0.00926827,-0.037909925,0.0501313,0.075681955,-0.0025623343,0.007465251,0.018014658,0.09861562,-0.07392249,-0.054195825,-0.04837008,-0.07505492,5.1387226e-05,0.09176103,0.014479003,-0.028048169,0.102964595,0.018285776,0.050354686,-0.056011163,-0.059771083,-0.035277545,-0.03850521,-0.032428965,-0.022120027,0.0056039845,-0.013108093,-0.012290256,0.016779568,0.022184707,0.0037788423,-0.053813394,0.03854334,0.072055265,0.024254322,-0.04730228,-0.044645287,0.0005562566,0.085286416,-2.9594635e-33,0.046549216,-0.11080747,0.045829643,0.0213428,-0.04169108,0.014921319,0.040733803,-0.080561586,0.019695476,-0.0944023,0.1011501,-0.028541394,-0.037684083,-0.030330358,0.046309676,-0.05905626,0.017119935,0.021403823,0.026249126,0.005937808,0.008821746,0.015020931,-0.05753525,0.07754265,0.03617076,-0.031128556,-0.006621705,0.015767502,0.07642956,0.01427323,-0.057668082,0.031875703,-0.037519813,0.05504271,-0.08909562,0.0887051,-0.042696964,0.061942533,0.026116403,0.06254009,-0.019710675,0.010280169,-0.016241096,0.066841625,0.000728266,0.10514009,-0.05924881,-0.027460676,-0.021327866,-0.07025154,0.116226055,-0.035064496,-0.018836796,0.041154977,0.041975036,0.03251715,0.03672923,0.020544317,0.020237777,-0.03242825,-0.010839097,-0.079851694,-0.011999972,-0.026737481,0.06452489,0.04070883,0.058794674,0.08576777,0.0027802447,-0.029718617,0.022722647,-0.04521801,0.036193486,0.05372995,0.07389754,-0.07179188,-0.019028097,0.04712997,0.0280679,-0.050385132,-0.02668775,-0.039535727,0.02711508,0.0026171422,0.013735452,-0.090531394,0.0306482,0.10183797,-0.016824361,0.11751162,-0.03950137,0.07711145,-0.057617415,-0.0515656,0.0033210171,-4.2671857e-08,-0.033077028,-0.039246712,-0.054372635,0.0018880678,0.04894017,0.12192447,-0.04709096,0.020067474,0.057874337,-0.047040187,-0.065505415,0.015458546,0.018380994,0.018947668,0.049892426,0.000754568,-0.07693329,0.049717285,-0.0063357116,-0.015053288,-0.15068726,0.11202179,-0.14163107,-0.0042284946,-0.03186531,0.034840766,0.008333565,0.015120275,0.091402575,-0.06656385,0.041923884,-0.0021488126,0.035576228,0.00023606609,-0.10370798,0.0305661,0.027653169,-0.05452033,0.0037082285,0.11870564,-0.034146167,-0.03311703,-0.076489374,-0.0014700128,-0.070814274,-0.06047644,-0.030556167,0.07049291,-0.08247314,0.012768607,0.054680575,0.016943863,-0.0069340635,-0.06323122,-0.009565787,-0.003595423,-0.0012065764,-0.102657445,-0.013945355,-0.029336007,0.02624937,-0.03517049,0.086302154,-0.011186 +2.1.1.75,"Converts apigenin into acacetin. Naringenin can also act as an acceptor, but more slowly.",384,1.0000001,-0.073442824,-0.009018653,-0.022024043,0.053245988,0.017992783,-0.021790389,-0.0019694213,0.013613162,0.018303648,-0.024002943,-0.0123749515,-0.010560937,-0.040506218,0.031314105,-0.02567018,-0.0054914374,-0.053290654,0.07916353,-0.06550222,-0.04503382,0.009222111,0.0240122,0.02307049,-0.06375861,0.030895634,-0.051360294,-0.023549316,-0.051626757,0.063782066,-0.08564406,-0.0068376567,0.051675078,-0.076570734,0.053372405,-0.08787936,0.07510498,-0.08220432,-0.019163482,0.021668926,-0.02848012,0.061388575,-0.0050647934,-0.023026353,-0.03328144,0.008773415,-0.07687069,-0.078262225,-0.019559985,0.015576386,0.05288262,-0.054798547,-0.019095669,-0.034142684,0.027347628,-0.014665679,0.013713311,-0.109035544,-0.024015998,-0.039566923,-0.0003734173,0.024997026,-0.030788627,-0.008500697,0.0061861784,-0.020577457,0.025653176,0.031138277,-0.016546259,0.008147724,-0.04294186,0.03247613,-0.016377019,-0.048787404,0.031454872,0.1042333,0.012751012,-0.016817486,-0.01264094,-0.009061786,0.025656855,0.03520156,0.070008256,0.029367307,0.052747134,0.0602086,0.032493096,-0.005427715,0.048951242,-0.049226087,0.06528175,-0.0032284574,0.027637353,0.069656864,-0.06760816,0.07578185,-0.046140894,-0.0059379097,-0.03712175,-0.09256084,0.05095487,-0.02577233,0.06405738,-0.0487451,-0.054199442,-0.027626023,-0.024197891,0.024244513,-0.04229157,-0.009950061,0.02226024,0.00086861145,-0.07392987,0.110317245,-0.008427432,-0.023647765,0.15206876,-0.045365326,-0.055777904,0.076170415,0.046636067,-0.007985929,-0.0054260856,-0.044934735,0.05731742,-0.009123706,0.045473017,0.017595286,2.4846869e-33,-0.0647271,0.04275244,-0.015567981,0.07447914,-0.014953666,0.021595009,-0.06225464,0.014191581,0.012020883,-0.11937553,-0.15436116,0.009467571,-0.033265885,0.12424163,0.00404836,-0.082957245,-0.0045824256,0.02514225,0.009252692,-0.020935893,0.035202906,0.07340788,-0.068600245,0.0043979664,-0.051578086,0.010680523,0.008542983,0.054422475,0.010350477,-0.044088874,0.009714818,0.012336667,-0.007860253,0.06955116,-0.0032919778,0.013501226,0.057125647,-0.017079743,0.021342868,-0.003207657,-0.036513582,0.064706035,-0.057906177,0.030136105,0.06562119,-0.037303776,-0.05761367,-0.020369885,-0.024132608,0.037990496,0.06394602,0.06720539,-0.010870416,-0.007721556,-0.074285194,0.008713784,0.027368575,0.0015030064,-0.0073816287,0.037283946,0.02872686,-0.0055521866,0.03126088,0.040018544,-0.07467241,0.094386265,-0.011035004,-0.054249678,-0.013439287,0.023989763,-0.034837287,0.032313135,-0.019848417,0.072723016,0.081374206,-0.0315126,-0.035963923,-0.017831063,-0.016595488,-0.026640693,-0.030337613,0.0072416817,-0.029909119,0.097008035,-0.034634884,-0.0869183,0.031381156,-0.055986654,0.08784931,-0.034592763,0.070849724,-0.028891126,-0.10467401,-0.0023211495,-0.008095487,-2.9395554e-33,0.09184972,-0.10636282,0.0053719156,0.04015097,-0.031036174,0.06900739,0.016308967,0.01989037,0.055989757,-0.0020852687,0.10904356,0.018196633,0.06364067,-0.019075941,0.013628447,-0.06380015,0.0061814007,0.026556652,-0.021521049,0.07521544,-0.04375962,0.06214861,-0.035222135,0.00024161086,0.030221827,0.07279115,-0.011292074,0.058897726,-0.0018066904,-0.0010681658,-0.061177485,-0.010759589,-0.06927045,-0.10699932,-0.05503644,0.07494862,0.07315221,0.021297188,-0.14333878,-0.047961116,0.042914033,-0.06431343,-0.045805153,0.0874048,0.05028918,-0.016892402,-0.032049537,-0.031101927,-0.061428923,-0.013363622,0.07062628,0.06241831,0.05884108,-0.08481995,0.044669952,0.0529141,0.055753034,-0.107989505,0.0035902027,0.01593342,-0.020489903,-0.07901171,0.09328655,-0.015849505,0.006692289,-0.0070029995,-0.040917728,0.076129,0.021031883,-0.025333775,0.12962158,0.016393414,0.041988995,0.061578825,0.016380051,-0.07552772,0.044472933,-0.0535951,0.01191509,-0.11239601,-0.16905576,-0.042971388,0.02862131,-0.05413961,-0.037999112,-0.021385843,0.041677296,-0.037156038,0.0141601,0.05523355,0.0052765096,-0.0031707464,-0.07187178,0.003035449,0.017225208,-2.7019464e-08,0.049100604,-0.004003609,0.0355675,0.00970875,0.010746204,0.04799048,-0.031231174,-0.0089851795,-0.029397283,-0.022761839,-0.0070499787,0.12119512,-0.0022463708,-0.040960953,0.027188836,0.07917111,-0.011671688,0.049210165,-0.031685527,-0.036317542,-0.12614651,0.07939439,-0.061438017,-0.07792454,-0.00989913,-0.038387164,0.014486801,0.094576575,0.026877081,-0.054759543,-0.05524578,0.010521665,0.076017834,-0.060190193,0.011352151,0.04960285,0.032224342,-0.020428948,0.02610281,-0.06450893,0.01590061,0.04087649,-0.058099538,-0.012896688,-0.052087944,-0.04390372,0.08870044,-0.0373227,0.06869001,0.007910681,0.08638664,0.033453133,-0.0012508788,-0.045435887,-0.062677115,-0.016964031,-0.05710011,-0.037818782,0.00044014718,-0.02875561,0.0009383223,-0.010955721,0.11509296,0.0732926 +2.1.1.76,"Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.",384,0.99999994,-0.07054445,-0.10933799,-0.1407732,0.057198517,0.028273024,0.040135823,0.003245031,0.013271431,0.047720596,-0.08714407,-0.019626148,0.007634833,-0.09094951,-0.02041245,-0.06864348,0.0117672365,-0.044953987,0.059994865,-0.07603325,-0.020881101,0.07629013,-0.032768514,0.07654441,-0.013170031,0.03970297,-0.042702273,-0.00997806,0.008291311,0.042077385,-0.056201495,0.015655728,0.056833144,0.0038028313,0.02151832,-0.05685019,0.03740859,-0.025070624,-0.056000777,-0.024368573,-0.011512545,0.07402681,-0.00787363,-0.041452963,-0.028866233,0.04421294,-0.09403093,-0.06994169,0.004022351,-0.027683506,0.028863797,-0.07042814,-0.07540711,-0.06842351,0.041540425,0.059371207,0.016124615,0.012021928,0.007898632,-0.003883552,0.090405844,0.02864116,0.031880643,0.010605295,0.014278372,-0.02253708,-0.022153499,0.05834743,0.009855143,0.04698242,-0.032901585,-0.03890832,-0.0583477,-0.026369544,0.019577045,0.019248813,0.13839284,0.017403832,0.0056280335,-0.065797396,-0.04550753,0.031881683,-0.011167953,0.0018064465,0.055486698,0.013129921,-0.069150165,-0.051146176,0.009914606,0.06633094,0.09350283,0.048916534,0.06471153,-0.048822302,-0.054865085,-0.00078336976,0.048004143,0.078797,-0.05328518,0.006013124,-0.029138826,0.019935979,-0.07050278,0.01689819,0.011556157,-0.025364326,0.029528877,0.03827145,-0.03365123,0.06316194,-0.06356328,-0.008477106,-0.04800523,0.02248547,-0.07778207,-0.032998327,0.04648415,0.014456098,-0.007946341,0.007973531,-0.008895089,-0.05329594,0.09344612,0.043252528,-0.0435463,0.009026015,-0.02737201,-0.07903004,7.723205e-34,0.11483918,0.03681223,0.014885571,-0.04654511,0.036708433,-0.0036188064,-0.016803555,0.03802873,0.038996633,-0.032037262,-0.04920728,-0.05572017,-0.029154813,-0.026216108,0.037072834,0.033888817,-0.0082402695,-0.09637766,0.015051381,-0.0129577285,0.031214528,0.005196093,-0.14909747,0.06399237,0.017903876,0.029529335,0.020320047,0.04476805,-0.009517512,-0.014429092,-0.0009738706,-0.09685404,-0.030336583,0.014263326,0.0121227475,0.10161369,-0.040880788,-0.02030648,0.0057530287,0.03213779,0.01367098,-0.047728904,0.019125197,-0.00806012,-0.06273463,-0.027394615,-0.07737529,-0.008730272,0.047829837,-0.014459592,0.01750336,-0.051744726,0.07933131,0.061368648,0.0004469459,0.063050374,-0.058557257,0.022801185,0.06905257,0.020510452,-0.01185042,-0.080431305,0.031396884,0.042021964,-0.0055472907,0.033170015,-0.0800588,-0.032711867,0.005922621,0.04038021,-0.024839165,-0.020825975,0.0905781,-0.02192337,0.111899555,0.022060515,-0.090457864,0.016695606,-0.018940268,0.07988953,-0.008012922,0.010462898,-0.009555491,0.042412363,-0.1317777,0.030557897,0.067914896,0.03535596,0.027009804,0.016612623,0.0027793976,-0.0864838,-0.013299217,-0.009582267,0.010519377,-1.609109e-33,0.047731664,-0.060320806,0.09815068,-0.009469455,0.0020479779,0.068827465,0.015157503,-0.07045792,-0.047000892,-0.06819867,0.060867917,0.011880668,0.048487127,-0.058121834,-0.036729652,0.04340234,0.0010622717,0.08862374,0.026502345,0.05239319,-0.042918984,0.022589529,-0.028155005,0.056959372,0.0854709,-0.022634504,0.026309451,-0.05489053,-0.034931824,0.08655726,-0.015410987,0.001507508,-0.012337569,-0.07046436,-0.01764413,0.0036929864,0.01810504,-0.012190013,-0.09133029,0.013862809,0.0063253855,-0.01883329,0.076897345,0.1133384,0.027270595,0.07819084,-0.07044943,-0.033512015,0.02340183,0.013160197,0.0684568,0.07923445,-0.027537234,0.087216794,0.0557533,0.017465554,0.034494203,-0.019775553,0.024350269,-0.028858952,-0.042514753,-0.056889217,0.010904656,-0.041589063,0.04100525,0.07484303,0.010213502,0.05280586,0.06908483,-0.08952625,0.044234566,-0.07147078,0.056241658,0.14975792,-0.051126678,-0.027078878,-0.015452217,0.042721342,-0.048308,-0.017724069,0.069777824,-0.029098818,-0.039620407,-0.056732032,-0.08143461,-0.05128253,0.048322298,0.07551637,-0.007909621,-0.040936433,-0.083106995,-0.012382692,-0.11650604,0.023704696,0.033313435,-2.7915709e-08,-0.0049091056,-0.082564026,0.024397394,0.025249587,-0.0033345744,0.031611826,-0.032497425,0.04418692,-0.034778565,-0.005507896,-0.034305338,0.08991813,0.0048522777,0.057469785,0.021386148,-0.039797746,0.0073038037,0.026759574,0.0044236085,-0.078753784,-0.09419379,0.042764947,-0.098660566,-0.020305607,0.011478699,0.0072278343,-0.024670182,0.1059653,0.09761526,-0.058459666,0.052996732,0.030748812,0.05406031,-0.031438608,-0.11458999,0.026214017,0.007767874,-0.06542091,-0.0012019802,0.028385658,-0.062413055,-0.002956971,-0.018717669,-0.006586749,-0.08647178,-0.045898847,0.056300793,0.08159251,0.03124854,-0.01563915,-0.005236172,-0.014991842,-0.0016648284,-0.049034778,-0.04323295,-0.006170984,0.10381345,-0.003233311,-0.024777798,-0.07895239,-0.002860748,-0.081541255,0.122882895,0.028153995 +2.1.1.77,D-Aspartate (but not L-aspartate) residues in proteins can also act as acceptors. Previously also listed as EC 2.1.1.24.,384,1.0,-0.06195203,-0.08771313,0.0069049774,0.0014647536,0.14302035,0.0039086347,0.033746716,0.041071154,0.05505067,-0.019444142,0.078050815,0.022127982,-0.0889917,0.050445788,-0.01973369,-0.009653671,-0.0071173096,-0.020182997,-0.03122054,0.026253015,0.009867744,0.06889014,-0.022390358,-0.01805563,0.019991497,-0.021631014,0.01121789,-0.023887394,0.06002716,-0.13434981,-0.013763035,-0.061693862,0.021966614,0.038443293,0.0047558434,0.0149633875,-0.0074838223,-0.09408141,-0.050970834,-0.005643859,0.093195185,0.009567982,0.054397725,-0.060526412,-0.04094877,0.003345732,0.014260755,0.024600679,-0.0038093033,-0.04578446,0.05245895,-0.019540558,-0.0026117396,0.07341389,-0.0767893,0.055822354,-0.096660174,-0.02346732,-0.029695367,-0.022457935,-0.01730786,-0.0063999672,0.046785116,-0.023905072,0.04233952,-0.09710321,0.028904073,-0.07749834,-0.011269418,0.015254055,-0.017618846,-0.0494864,0.037676934,0.06609451,0.10989408,0.058421835,-0.067763925,-0.027527107,0.065936506,-0.009874001,-0.012150633,-0.035461154,0.013288653,0.014392404,-0.020810097,-0.036827374,-0.06419534,0.044824164,0.011648548,0.03154689,-0.029692683,-0.08270017,0.07200025,0.016208578,-0.052954365,-0.032624487,0.117913425,0.0744561,0.028030962,-0.040854514,-0.041930925,0.110443875,-0.075651556,-0.0413556,-0.025541341,-0.027564967,-0.036751505,-0.021764208,0.02478623,-0.08091078,-0.0033075402,-0.12210806,0.12701386,0.014882035,-0.02579886,-0.02014856,0.009328002,-0.10003165,0.047717147,-0.06664069,-0.0029929574,-0.027190503,0.020959357,0.04313333,-0.028531816,0.07737495,-0.11225364,-2.3050138e-33,0.011207593,-0.0032288947,0.0047013937,-0.0013328886,-0.06407073,-0.005657403,-0.07187016,0.0020234936,-0.00838316,-0.08808417,-0.074775636,-0.061172727,0.09285353,0.07554548,-0.016677668,-0.041358948,0.022466058,0.06238614,0.048410065,-0.03541764,0.05057634,0.061428864,-0.066549,0.016249735,0.026284872,-0.001543107,-0.0673796,0.032396577,0.069675446,0.014465363,-0.05812341,-0.049564213,-0.026202865,0.08662705,0.014365071,-0.0136838695,0.03534684,-0.010744813,-0.028610582,-0.09113032,0.00655015,0.0030858691,-0.10900921,0.0034704162,0.002890187,-0.035756394,0.029006772,-0.0036736596,-0.0019980588,0.028064096,0.013729932,-0.06826228,0.05314707,-0.09832506,-0.008263688,-0.013545611,-0.05746929,0.026848905,-0.006147433,0.07726355,-0.02539981,0.07136448,-0.081417516,0.003412479,-0.031729676,0.041458227,-0.018632334,-0.053545777,-0.026390987,0.038810305,-0.08137096,0.0006977384,0.078123696,0.029014323,0.046458412,-0.053442117,-0.0918707,0.031606205,0.0196055,0.035234034,-0.08233337,-0.021480227,-0.05704495,0.05696403,-0.059041288,-0.042885542,0.07455475,-0.068532676,0.03668527,-0.024977352,0.0059724725,-0.049723618,-0.029432843,0.060588468,0.03037787,-1.3294287e-33,0.022242619,-0.059014883,0.027877009,0.029599465,-0.0055342154,0.091106966,0.07559068,-0.00095866696,0.1361237,-0.106719784,0.08558047,-0.008191077,-0.00094744057,0.0030526796,0.025772749,-0.017846012,-0.12378649,0.05942023,-0.01568676,0.036893696,-0.05249772,-0.04871641,0.033800766,0.05680038,0.0148508195,0.062293924,-0.030281048,-0.018495457,-0.018703427,0.055176754,-0.023914833,0.04601173,-0.021435952,-0.047197722,-0.050667793,-0.010002709,-0.0812115,-0.043594174,-0.032831743,-0.05573118,0.031394627,0.029384563,0.027932055,0.11597689,0.047153264,0.001766185,0.050555743,0.0417278,-0.02883839,-0.058348782,-0.041128658,-0.0012672254,0.05406956,0.05579129,0.012203441,0.10801771,0.05466846,0.04722406,0.0096384585,0.061629806,-0.039307624,-0.032963786,0.038151033,0.0062300293,0.027520807,-0.064044714,-0.033578847,0.03842573,0.03588476,-0.018906847,0.0956775,-0.025425589,0.023833023,0.05410853,0.057143677,-0.08864093,-0.058561448,0.0011467632,0.021724703,0.0032407267,-0.13446698,0.048092943,-0.0012826738,-0.02185344,0.08720469,-0.034847222,-0.046405077,0.026805997,-0.04748681,0.037591085,-0.042127986,-0.052397653,-0.0061528427,0.12283277,0.05615495,-3.356265e-08,0.040844306,0.02104191,0.023294877,-0.06868065,0.031631865,0.0345537,-0.05927607,-0.016797623,0.0072777956,0.058180295,0.022761038,0.05574313,-0.01684634,-0.09136221,0.058754787,0.03734766,-0.042746495,0.06112811,-0.032261565,0.04169918,-0.020006834,-0.020790007,-0.055047337,-0.05914472,-0.012192152,-0.012935399,0.014629445,0.058525223,-0.023073645,-0.02801279,0.023555756,0.021128004,0.040740374,-0.04439052,0.042298883,0.015606056,0.011157313,-0.07544133,0.0007807616,0.059314612,0.06759824,-0.013871506,-0.06773346,-0.01388566,0.0110956095,0.10164428,-0.006238428,0.021662671,-0.08272201,0.007256612,-0.02892226,-0.059556123,-0.04081597,-0.023416266,-0.05230777,0.014847588,-0.04488213,-0.05193905,0.0436073,-0.055007998,0.031267133,0.050218787,0.111411184,0.032161966 +2.1.1.78,Also acts on isoorientin 2''-O-rhamnoside. Involved in the biosynthesis of flavones.,384,1.0,-0.030509574,-0.07713399,-0.14970094,0.08065689,0.0735175,0.043369826,-0.050528415,-0.013885095,0.0499472,-0.06309575,0.056149688,-0.009188762,-0.13061707,-0.061041612,-0.05943793,0.03337636,-0.012342449,0.08597041,-0.047612824,-0.028965332,0.07399879,-0.050297678,0.06359905,0.0031452673,0.0025865445,-0.026975611,0.011434102,-0.0010654274,0.06389488,-0.07135455,0.074408635,0.0013374471,0.058689535,-0.06161635,-0.053631198,0.052461248,0.03328739,-0.046942305,0.0718105,0.00075798173,0.05967844,-0.030414995,0.049309522,-0.0076162,0.038557924,-0.056693472,-0.06276922,0.055649754,0.03883481,0.045655128,-0.066848196,-0.013262781,-0.08256505,0.03775936,0.01101508,-0.016953059,-0.050243136,0.011607805,-0.04979366,0.007531283,0.05296202,-0.030293027,0.01263475,0.031028492,-0.10212752,-0.052417193,-0.00422462,0.0108687235,0.030714652,-0.01449842,0.03676777,-0.053765748,-0.045336545,-0.021238847,0.010861139,0.103155114,-0.052477382,0.015718672,-0.08634512,0.014523056,0.053632855,-0.024075722,0.062170483,0.062691174,-0.015711144,-0.059212595,-0.050631348,-0.005295249,-0.015184675,0.0681317,0.041068636,0.015852494,0.05456146,0.022254417,0.0122684315,0.014936503,0.07096873,0.013809081,-0.041448563,-0.03463396,-0.07691659,-0.028056499,-0.05860927,-0.061604206,-0.053638734,-0.0020829486,-0.08061409,-0.027274618,0.04131957,-0.025604347,0.01618788,-0.014905927,-0.017872382,-0.06683877,-0.019725274,0.07239351,-0.022625176,0.002319491,-0.04485983,-0.009714677,-0.02303568,0.046800427,0.044773117,0.05846613,-0.013186825,-0.06167638,-0.05037117,-1.7250872e-34,0.07333895,0.07023836,-0.03196995,-0.019671295,0.02083325,-0.047368873,-0.025887124,-0.032715306,0.0173989,0.0106231645,-0.106646284,-0.042112913,0.013532454,-0.00541517,0.02166997,0.009004714,0.04622673,-0.0744034,0.079452716,-0.04642483,0.016046878,0.07184286,-0.06638798,0.044792753,-0.011413257,0.026567811,-0.017822297,-0.02221278,-0.015823482,-0.007912661,0.02517402,-0.068234235,-0.04990249,0.050355297,0.016109264,0.012607457,-0.06241187,-0.07566764,-0.057953056,0.015417905,0.01355075,-0.027651027,-0.00487935,-0.023779428,0.052901845,-0.028601399,-0.03825813,0.044809524,0.13934387,0.12527043,0.0070695076,-0.024947193,0.12265343,0.09910005,-0.06455092,-0.048412096,-0.051403742,-0.016593238,0.03360092,0.047256455,-0.025611384,0.0022623038,0.04764956,0.00822584,-0.07102314,0.029580798,-0.043557778,-0.057898432,-0.045292825,0.05783734,-0.008139523,-0.08114888,0.06701361,-0.012039258,0.10405824,-0.0209443,-0.040579308,-0.027698198,0.052976113,0.07383431,-0.015859794,0.015899505,0.02221958,0.012149618,-0.041507564,-0.0046054944,-0.057856243,0.03968828,0.050231993,0.06824556,0.024868911,-0.035459425,-0.07068248,0.057960253,0.045450445,-2.140468e-33,0.04908168,-0.09922352,0.02108507,-0.01580423,-0.053681996,0.0371007,-0.06864764,-0.015593961,-0.013055184,-0.03331178,0.02924424,-0.06357894,-0.031860135,0.014424725,-0.038488142,-0.043822717,0.032912817,0.12322239,-0.017542517,0.011099621,-0.069016725,0.018538106,0.02454051,0.029350841,0.073643595,-0.008450077,0.08824998,-0.0432469,-0.008362772,0.10839057,-0.027591757,0.03629015,-0.117734365,-0.02539035,0.037104707,0.08409608,-0.004884303,0.058702223,-0.061395332,0.027301108,-0.01738663,0.030384347,0.015721606,0.058607172,0.10186219,0.026606085,-0.041682795,0.03993645,-0.054837074,-0.026132487,0.02384952,0.06257413,-0.016172657,0.08280928,0.09293979,0.030604854,-0.04152855,0.031869125,0.046477463,-0.018543053,-0.01694274,-0.12117639,-0.011486421,-0.027371226,0.08634216,0.08510937,-0.011594775,0.091245785,0.03118,0.014774278,0.06900748,-0.03691955,0.03568646,0.09432293,0.0017107007,-0.034930915,-0.056927644,-0.07262708,-0.05199485,0.0036516876,0.026399149,-0.033845656,0.04276719,-0.049267888,-0.09519491,-0.038310155,0.028986156,0.036535177,-0.0008201723,0.03291575,0.01503762,0.00029921957,-0.05800247,-0.00021144951,0.02822319,-2.5735538e-08,-0.0030952366,-0.051151577,0.09117885,-0.01206476,0.005110202,0.006955909,-0.009626868,0.01280929,-0.08014723,0.012066427,-0.06985291,0.102948286,0.0478356,-0.018265044,0.04981814,-0.016396925,0.014550842,0.06854619,0.0045318203,0.011477474,-0.06289146,-0.019706517,-0.07824257,-0.028758854,-0.0075053195,-0.063624226,0.012299639,0.047863346,0.102382936,-0.032364264,0.12231936,-0.02967945,0.035141673,-0.032602735,-0.11569014,-0.029825097,-0.0028843635,-0.044771224,0.005769362,-0.050073087,-0.10977759,-0.0029608456,-0.0012442555,0.03663554,-0.0054175947,0.0021032388,0.010281278,0.03777154,-0.033495653,-0.047080036,0.020132016,-0.046550613,-0.018947072,-0.048819777,-0.062031314,-0.04688423,0.07314801,0.013818655,0.022559142,-0.075163566,-0.06819028,0.020611778,0.1310782,-0.02955139 +2.1.1.79,"The enzyme adds a methylene group across the 9,10 position of a Delta9-olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol, forming a cyclopropane derivative (cf. EC 2.1.1.16 methylene-fatty-acyl-phospholipid synthase).",384,1.0,-0.06639198,-0.016647937,-0.1260456,-0.006693026,0.05769189,0.021867434,-0.027349059,0.07591226,0.031308092,-0.060287677,0.07098371,-0.045782395,-0.05712297,-0.002641461,0.008995421,0.01491113,-0.08677778,-0.012593819,-0.03164128,-0.079576515,0.04394081,0.013894185,0.022124331,0.038403597,-0.04834539,-0.052082494,0.003568142,-0.019604629,0.030313415,0.012490501,0.019105418,0.030478008,-0.025283258,-0.0132293245,0.007659368,0.054393705,-0.027175082,0.0029593369,-0.032928612,0.029233664,0.08068692,-0.005090177,-0.016639631,0.023555733,-0.058070302,-0.01983111,-0.0058958447,0.052123714,0.015977371,-0.0422628,-0.00716584,-0.07884234,-0.06873187,0.01984004,-0.029930344,0.062052846,-0.11183529,-0.03019436,-0.0009541428,-0.04402738,0.004154125,0.072630875,-0.026206631,0.0676568,-0.0168663,-0.04834155,0.0503124,-0.095221095,0.022226457,0.013196729,-0.059816714,-0.09763308,-0.054088797,0.010385276,0.04003795,0.050694577,0.04226929,-0.01662792,0.057082828,-0.039903466,0.04955295,0.004935598,0.01524871,0.03255366,0.03588167,0.031916242,0.02101445,0.043445144,0.018510249,0.022499692,0.07686579,-0.041542903,-0.005773415,-0.015210225,-0.046698492,0.07561506,0.011872063,0.0012722033,0.029549109,0.020694561,0.046675626,0.016736582,-0.07735744,-0.040621474,-0.05829045,0.00010993517,0.047829285,0.0306269,-0.04707927,-0.03360566,-0.02925171,-0.0019348921,0.059000857,-0.04698915,-0.02502706,0.01439046,-0.017588634,-0.00945488,0.04573358,-0.041692182,0.008151438,-0.019191403,-0.031405322,0.021840818,-0.03953536,0.07191288,-0.16042668,4.8010855e-33,-0.0053104386,0.06767858,0.041624203,-0.099692136,0.031426836,-0.03265928,-0.06285244,0.043408718,-0.071972124,-0.009018037,-0.045490287,-0.06934902,-0.020193022,0.07542896,-0.060886737,-0.07882819,-0.01875252,0.09045421,0.060578894,-0.040645216,-0.04920077,0.06377248,-0.012887651,-0.002037809,0.009714602,0.0565265,-0.07198088,0.007043825,0.038745895,0.009607546,-0.074548274,-0.0748241,-0.112489745,-0.0175955,0.020113936,0.06021898,-0.02288831,-0.07616135,0.014066139,0.035387583,-0.028297111,-0.027501915,-0.01824484,-0.012481736,0.017407706,0.037774965,-0.11984948,0.06553262,0.04046292,0.029967222,-0.023014631,-0.012550404,0.07733406,0.017034488,-0.082674265,0.02110447,-0.058749147,-0.031505033,-0.01495878,-0.044116456,0.0022028969,0.07077271,-0.05697135,-0.007106508,0.016271157,0.00016666643,0.008735741,-0.0203461,-0.052499175,0.02683553,0.009229215,-0.011371233,0.034115147,0.042387944,0.12543929,0.0035572494,-0.024486883,0.0058734925,-0.0006081061,0.036951955,0.010513181,-0.021875478,0.015087757,-0.010362155,-0.027762825,-0.0059535326,-0.014154235,-0.015822642,0.042214632,0.029448764,-0.035299715,-0.11307316,0.037695363,0.099342085,-0.030017331,-6.455555e-33,0.03201897,-0.0582356,0.050604034,-0.11931442,0.008620736,0.023634069,0.06156778,-0.036231264,0.041803423,-0.06619092,0.07571638,-0.0011905805,-0.012368973,-0.061379004,-0.026485298,0.012471535,-0.014176948,0.093876585,0.055618007,0.040843077,-0.034935843,-0.004628416,-0.012689559,0.16780272,0.062310614,-0.023807252,0.0055222893,0.09624419,0.01319891,0.022228617,-0.03399812,-0.028683813,-0.028725328,-0.05008653,-0.05649808,0.0565122,-0.053528737,0.009369899,0.0041353684,0.065457135,0.0001820557,0.0022154958,0.053259294,-0.013149828,0.06268526,0.10527579,-0.039957043,-0.005763851,-0.039187916,-0.030116968,-0.011704615,0.08206878,0.024980359,0.076373,0.03290847,0.13620943,0.01818501,0.05106728,0.031336963,-0.112452246,-0.051990364,-0.03649745,-0.055630453,0.048072293,0.042049587,0.07107936,0.011595793,-0.018285997,-0.031947162,-0.013038743,0.034557395,0.03608633,-0.030311093,0.03882139,-0.07364082,-0.0790765,0.0187267,-0.093830004,-0.030596828,-0.0045582377,0.060953233,-0.03154132,0.05184987,-0.06436194,-0.07618311,-0.04189661,0.026421119,0.1142148,0.025101392,0.016779702,0.021656707,0.0119687235,-0.05250558,0.035478354,0.06915664,-4.8127497e-08,0.0438632,-0.10290322,0.04081428,-0.13391973,-0.058821194,-0.0066991854,0.06575433,-0.056886476,-0.0056765694,-0.05641385,0.015321746,0.05500744,0.06063599,0.053543497,0.030527322,0.04065821,-0.09352747,0.05933932,0.040932283,-0.021573719,-0.07788446,0.039271463,-0.014565112,0.012462109,-0.01398337,-0.00942544,0.034869727,0.07159594,0.0030323174,0.021940289,0.032986283,0.07474955,-0.028321058,0.039846957,-0.00014579111,0.029895019,-0.0637368,-0.057170507,-0.021310737,0.060506683,-0.008823933,0.0018000123,-0.018339949,0.012136051,0.0740214,-0.033132385,0.024435025,0.051619582,0.03248839,-0.030377341,0.032762196,0.030851675,-0.07045685,-0.08637114,-0.02284465,-0.10339399,-0.07071445,-0.05017944,-0.057083502,-0.06030158,0.0026165969,0.04933068,0.21687381,-0.08433686 +2.1.1.80,Forms ester groups with L-glutamate residues in a number of membrane proteins.,384,1.0,-0.053490702,-0.12438186,0.013012083,-0.036576584,0.011655451,0.055225525,0.058172084,0.0138542205,0.0904044,-0.021269957,0.08421117,-0.05098248,-0.04436195,0.029759852,0.05958129,-0.031617694,-0.091547996,-0.037291378,-0.07276831,-0.063010104,0.10541429,0.08199154,-0.09591915,-0.07298332,0.0698319,0.046212953,0.06320657,-0.03666923,0.076497085,-0.07161624,-0.029314155,-0.07488055,0.02746432,-0.042239983,0.025440432,0.0070641087,-0.0931577,-0.12303432,0.109267786,-0.06299632,0.08222187,0.055848002,-0.022073528,-0.09855075,-0.053032666,-0.0063550444,0.061995503,-0.025443178,0.03141629,-0.012354498,0.06404975,-0.051031753,-0.018520711,0.018307168,0.0014525633,-0.048449818,-0.07943033,0.018420521,-0.0025152809,0.08849284,-0.038761653,0.051833607,0.04960995,-0.04413457,-0.06361363,-0.044026453,0.08811214,0.008503131,0.073875055,-0.04397793,-0.030757328,-0.054263953,0.063081406,0.021219818,-0.040236223,0.029543942,0.0625757,0.016844556,-0.0346445,-0.019849394,0.07209869,-0.036082722,0.008409148,0.09664908,-0.022359377,-0.03399198,-0.03682589,-0.0007030013,0.04906349,0.053296953,0.04272902,-0.046803366,-0.03064412,-0.0020719608,-0.051219072,-0.0071857357,0.030644316,0.010873103,-0.019219378,-0.01752691,0.030111907,0.06891951,0.075590156,-0.0808141,-0.028164951,-0.0052354843,0.023578925,0.018333526,-0.05296888,-0.03385,0.051225487,0.028346723,0.063539065,-0.01650056,-0.069102794,-0.07809547,-0.0075487383,-0.05578732,-0.033195306,0.07991484,-0.0038202119,-0.010409957,0.031829752,0.05570217,-0.024899513,0.013114585,-0.10992889,-1.830721e-33,-0.0021648766,0.0087487735,-0.030381825,0.020744633,-0.0067802616,-0.10092029,-0.05675244,0.015440251,0.0028654842,-0.03736354,-0.095293865,-0.1115824,-0.038456738,-0.012826058,0.022646202,0.020949183,-0.027603727,0.009326303,0.06931239,-0.053910922,-0.056284435,0.06448692,-0.028779175,-0.058465183,0.04158306,0.007654685,-0.035381828,-0.032814015,0.05774272,-0.0011412852,-0.015493255,-0.07114934,-0.0807703,0.072170086,0.04659732,0.022314982,0.014078223,-0.029548971,0.059156958,0.032911666,0.0223298,0.044116456,-0.077529185,0.0217395,0.031551044,0.025452929,-0.07667378,0.08319501,0.0013173642,0.0023362958,0.0029327,-0.09676625,0.03119752,0.0067583867,-0.043072913,-0.0019986175,-0.06692559,-0.00865883,0.042052694,0.049273986,0.04986455,0.09020583,-0.122712664,-0.0015392499,0.07006513,0.017673003,0.004370304,-0.062488124,0.006720916,0.029842116,-0.019848598,-0.08262826,0.1104598,0.028671663,0.042055402,-0.02388259,-0.08742149,0.03293898,0.056743834,0.08686269,0.0447038,0.024092639,-0.0029692363,-0.0044872602,-0.06588745,-0.0010081532,0.048159506,-0.0075918655,0.0025609504,-0.0082608815,0.012814065,-0.01543707,-0.002811309,0.039837617,-0.11787633,-1.5565538e-33,0.070123896,-0.07549671,0.0804292,-0.045224935,-0.057132743,-0.00026363472,0.030494085,-0.023306768,0.010673944,-0.017976465,0.033263545,0.017849028,0.03555533,-0.033912122,0.009512915,-0.004245908,-0.046957888,0.05877159,0.0042487704,-0.0093665235,-0.006241576,-0.00654434,0.054076836,0.0871443,-0.010298411,-0.010710368,-0.001841338,0.036658224,-0.0104483375,0.07120642,-0.002459979,-0.046534292,-0.011748429,-0.08143789,-0.019912578,-0.00035412193,-0.0070977006,0.010516954,-0.01419617,-0.0013507829,0.033543833,0.07621541,0.10143124,-0.044810645,0.009515005,-0.01258231,0.04801783,-0.05985903,-0.082079716,-0.07339155,0.03164491,-0.029022902,-0.022944052,-0.07309288,-0.049900863,0.044109434,0.052560356,-0.017506996,0.007932992,0.015924282,-0.07081526,-0.07775321,0.027389163,-0.0041576945,0.017812127,0.012056469,0.08493186,-0.07678453,0.043283958,-0.043454833,0.07143728,-0.0662546,-0.0065088295,0.033176612,-0.009571878,0.018662557,-0.06752592,-0.021312432,-0.002889241,-0.07917849,0.028132677,-0.0074956045,-0.054834735,-0.03520715,0.023207026,-0.019318638,-0.030455573,0.102600545,0.0666027,0.0049746986,0.013414038,-0.035652347,0.012691851,0.14521465,0.046063032,-2.391274e-08,-0.026966231,-0.021080963,0.027726784,-0.0058688764,0.030578988,0.057783652,-0.028946145,-0.06263563,0.06571902,0.038544178,0.055198524,0.035177168,-0.12888,-0.004044191,-0.0032973476,0.054797202,-0.06757756,0.09116344,-0.006968065,-0.015815318,0.030300861,-0.0004751058,-0.06883766,-0.05632354,0.111162126,-0.057586346,-0.061808355,0.0700893,-0.027963733,0.026502967,-0.00033951248,0.043622807,0.0028005114,-0.043890867,-0.039381355,-0.03000359,0.06286731,-0.07204302,-0.03876325,0.09348099,0.02892009,0.0025583648,-0.0148625765,-0.023666305,0.0086953575,0.052246395,0.024500905,0.03635825,-0.03699115,0.009802448,0.095492125,-0.034117453,-0.016286867,-0.009729214,-0.12350719,-0.061317828,-0.07137841,0.015568389,0.02768419,-0.029252023,0.014972637,0.0634094,0.06504847,0.01182255 +2.1.1.82,"Involved with EC 2.1.1.76 quercetin 3-O-methyltransferase and EC 2.1.1.83 3,7-dimethylquercetin 4'-O-methyltransferase in the methylation of quercetin to 3,7,4'-trimethylquercetin in Chrysosplenium americanum. Does not act on flavones, dihydroflavonols, or their glucosides.",384,0.99999994,0.017712072,-0.012298813,-0.11697697,0.05218781,0.036341663,0.052872084,0.029571066,0.009917095,0.05793754,-0.15568988,0.03133372,-0.031043893,-0.07894378,-0.066014655,-0.11718007,-0.030506331,-0.07819898,0.031069517,-0.0485289,-0.005389803,0.048156336,-0.052521188,0.069739506,0.058353376,0.02483507,-0.025445068,-0.03329874,0.035267986,0.018194653,-0.08744369,0.017313056,0.019473651,0.038824618,0.0034242808,0.0099204695,0.007921523,-0.004337686,-0.05366942,-0.036928058,0.03720869,0.05098565,-0.01447944,0.011709824,0.02462329,-0.07845122,-0.08382284,-0.011029347,0.000304678,-0.012305562,0.045069866,-0.008606224,0.03015283,-0.046254605,0.073651016,0.051138476,0.0023796186,-0.01885055,0.033958692,-0.01991424,0.036319807,-0.005585918,-0.013664817,0.03801943,0.01385485,-0.06270399,-0.021928143,0.018219322,-0.06318292,0.05379777,-0.06779427,-0.042031,-0.007587282,-0.031318884,0.08311154,0.055067237,0.16676609,-0.00355296,-0.027474333,-0.06689813,-0.031468585,-0.003137475,-0.05734823,-0.0032580374,0.015521999,-0.04185536,-0.06923464,-0.042774048,-0.017106991,0.049882665,0.12540066,0.068130866,0.042660687,0.0072672875,-0.017121129,-0.070213415,0.11525748,0.107439436,0.045368206,-0.0084203705,-0.010771103,0.038733132,-0.007939617,-0.111833975,0.0044392836,-0.050766494,-0.021143934,0.05856156,-0.0055474285,0.019627046,-0.073139496,0.026556578,-0.063106656,0.019292044,-0.042024594,-0.05395291,0.0052682445,0.01173594,-0.08286001,0.0037588216,-0.09432551,-0.015305177,0.037348434,0.0190746,0.00972375,-0.0029874519,-0.041839287,-0.07099774,6.094008e-33,0.06566159,0.09441537,0.057078086,-0.011362107,-0.039031923,-0.025748568,-0.061798442,0.03794942,-0.010014756,-0.13099347,-0.07125044,-0.046511345,-0.030927232,-0.05157353,-0.0026333984,-0.0071294634,0.016580878,-0.0534934,0.029260473,-0.00049152266,0.056643046,0.017783338,-0.07110797,0.061954185,-0.012229778,0.009578798,-0.0021358759,0.03447241,0.04233987,-0.028713204,-0.036750235,-0.05971358,-0.024552595,0.040529437,0.045418076,0.077919535,-0.005752737,0.0074177133,-0.00021796305,0.075541936,0.019323839,0.033014283,0.04337581,-0.0007500172,0.0122748725,-0.021579774,-0.07609896,0.05750784,0.06571811,0.005282511,0.0026045667,0.007947287,0.14831871,0.01732138,-0.007081188,-0.0065995804,-0.037651207,-0.04927124,0.049292095,0.020883515,-0.0027988888,-0.010765127,-0.0019199675,-0.026055919,-0.037180413,0.0131063955,-0.07038538,-0.025458537,-0.029655313,0.019278279,-0.01911955,-0.0012880629,0.10485061,0.023413131,0.13587415,0.024421219,-0.08700071,-0.032067567,-0.003534958,0.037199665,-0.057130493,0.019492645,0.019675648,0.010113053,-0.04842947,0.011464657,0.007643965,0.017859718,0.07907695,0.05974922,-0.040349193,-0.08667888,0.008014607,-0.027589358,-0.0071661947,-5.3170038e-33,-0.008664245,-0.03390714,0.05629009,0.01570848,-0.011403417,0.032957,-0.05210102,0.048947964,-0.030744009,-0.08108995,0.11471783,-0.027161233,0.041845217,-0.06883128,-0.0038850103,-0.031020215,0.035371725,0.07822923,0.0314868,0.07640392,-0.05370942,-0.022246834,-0.092420906,0.0749613,0.041606497,-0.0026332764,0.044932876,-0.045032963,0.043084055,0.0011241722,-0.036197376,0.000903919,-0.039272197,0.05319426,-0.05959291,0.047838613,-0.008009324,0.011067266,-0.042463534,0.0042570084,-0.025126245,-0.054794125,-0.013759517,0.0659242,0.045181688,0.086896725,-0.07879175,0.058494654,8.304257e-05,0.07423376,0.02798536,0.08567683,-0.075926684,0.095461555,0.051809024,0.01264526,0.07847113,0.023667233,0.021069381,-0.04054855,-0.053915124,-0.02631129,0.0135098705,-0.032860845,0.027298441,0.06402411,-0.027985478,0.14069977,0.025529994,-0.029205741,0.0581051,-0.01952546,0.036907524,0.018257542,0.035208657,-0.022828516,-0.006876868,0.030496007,-0.022292955,0.025486922,0.053962823,-0.023361254,0.04236371,-0.11164168,-0.012302364,-0.0039191293,0.031038009,0.07641289,-0.06022365,0.018572561,-0.04852371,-0.014184778,-0.08325013,-0.011629428,-0.014592135,-4.1639332e-08,-0.035023406,-0.06121606,-0.00058019307,-0.0018518394,0.024488766,0.032008238,-0.037371077,0.035345867,-0.024209091,-0.037303247,-0.010914638,0.0032497041,0.04935279,-0.01507339,0.013288735,-0.041644607,0.03897499,0.11153016,0.008367766,0.00066200836,-0.10777172,0.044005074,-0.13673823,0.008673079,-0.013007897,0.032014076,-0.008639961,0.049628936,0.046140317,-0.06785626,0.11821204,-0.025165848,0.04915595,-0.009866794,-0.08919731,-0.050373986,-0.024727447,8.919436e-05,-0.0045377035,0.005397525,-0.012116139,-0.012002382,-0.03435877,0.029371211,-0.012891555,-0.062237546,-0.026148152,0.12164124,0.018765505,0.027868442,0.045155976,-0.080589555,0.01577254,-0.107635595,0.0004201984,-0.06532563,0.089743346,-0.021012373,-0.04557846,-0.06968595,0.0016307413,-0.087409705,0.13796945,0.066016585 +2.1.1.83,"3,7-Dimethylquercetagetin can also act as acceptor. Involved with EC 2.1.1.76 quercetin 3-O-methyltransferase and EC 2.1.1.82 3-methylquercetin 7-O-methyltransferase in the methylation of quercetin to 3,7,4'-trimethylquercetin in Chrysosplenium americanum. Does not act on flavones, dihydroflavonols, or their glucosides.",384,1.0,-0.02355606,-0.055199333,-0.11416952,0.052178603,0.040965423,0.03474309,0.056234367,0.0009981605,0.05773874,-0.12530965,0.03692446,-0.035423107,-0.08481287,-0.04763393,-0.0854589,-0.035696834,-0.087725535,0.037774663,-0.055708706,-0.008139372,0.025039818,-0.03152167,0.064392515,0.0529123,-0.015161523,-0.03244018,-0.03732784,0.032125592,0.028856447,-0.105900645,-0.0005177841,0.028793689,0.021400055,0.029916484,-0.008290506,0.0016859558,-0.025801316,-0.02934368,-0.05082357,0.027117394,0.06074909,-0.03950379,0.025602808,0.017912867,-0.08185777,-0.111729905,-0.010115549,-0.015182704,-0.011594488,0.030333605,-0.0061947173,0.019021325,-0.038069338,0.08934452,0.031187497,-0.0028235759,-0.016282167,0.020147705,-0.016261652,0.021865927,-0.015205926,-0.02507184,0.019120129,-0.022492113,-0.06979613,-0.04824064,0.010017952,-0.075116254,0.037811987,-0.04278189,-0.011147475,-0.019992162,-0.027456123,0.07937817,0.08490218,0.18410681,-0.028900001,0.008134471,-0.06004758,-0.0099294195,0.0051134424,-0.065737925,0.010761834,0.033972684,-0.026811995,-0.076205455,-0.06453659,0.020256853,0.050847307,0.1194144,0.03568443,0.055790223,0.034326486,-0.040800348,-0.0516874,0.09492338,0.10471548,0.014226985,-0.006229409,0.0030804288,0.028560279,0.0036415958,-0.11318109,0.0069455155,-0.037703987,-0.009532411,0.038326938,-0.022194888,0.0309587,-0.098780975,0.00806603,-0.085850455,0.067352146,-0.022200162,-0.042593267,-0.003075526,-0.00017919941,-0.10140988,0.02106192,-0.11531755,-0.032907125,0.053359963,0.04472883,0.012096627,-0.023153841,-0.037938885,-0.06716219,6.640354e-33,0.03443853,0.09737119,0.04337274,-0.014068486,-0.04386277,-0.0036581892,-0.047088895,0.044021595,0.0016271059,-0.13557468,-0.08354004,-0.06600116,-0.018790193,-0.016009673,0.0017602278,0.0009415019,0.01723984,-0.031075785,0.029601017,-0.028227676,0.075100265,0.016089646,-0.10726189,0.052755617,-0.021287482,0.010987169,-0.026735373,0.060912002,0.07062094,-0.034633804,-0.023940822,-0.030006597,0.013023964,0.05889524,0.03226023,0.06525574,0.0054285517,0.016164323,0.017909005,0.048038255,0.010137777,0.009807696,0.01996008,0.031592257,0.03407143,0.00041007678,-0.05740581,0.037978638,0.04027794,0.01427404,0.008973537,0.009362309,0.13293049,-0.011279445,0.011540237,0.011208982,-0.014809694,-0.014457952,0.052540474,0.0074640713,-0.012244831,-0.0066263694,-0.0062814425,-0.02351328,-0.040152274,0.031141464,-0.041420087,-0.04474119,-0.02957007,0.037936278,-0.011242335,-0.0064595565,0.06088075,0.049727555,0.1258109,0.0141672045,-0.105759695,-0.022240145,0.0029972529,0.04543969,-0.069612965,-0.0029586297,-0.008638376,0.04111093,-0.07226606,-0.009799145,0.024794526,-0.008865946,0.07779574,0.041587524,-0.008256515,-0.08780504,0.0020711122,-0.011454239,0.01884745,-5.6846797e-33,0.024984978,-0.031336144,0.057672657,0.050839208,-0.0017807533,0.038683534,-0.04900016,0.016487665,-0.0048736488,-0.09626318,0.11019073,-0.016896186,0.052966904,-0.06259069,-0.003037393,-0.037656017,0.020964734,0.080555096,0.011915756,0.057435583,-0.035182007,-0.044829406,-0.12804808,0.09792213,0.03443683,0.007876744,0.019553652,-0.04240318,0.03984079,0.033148237,-0.06967392,0.011308947,-0.0311924,0.02118875,-0.04123288,0.025602981,-0.00842736,0.015975973,-0.06617719,-0.00086213584,-0.019486409,-0.091811,-0.014687836,0.07731267,0.046878234,0.071639515,-0.029132605,0.039558873,0.021471566,0.051516995,0.03797975,0.093846664,-0.044541173,0.05931002,0.07367537,0.029409545,0.091414355,-0.012910066,0.05816115,-0.013829404,-0.014399925,-0.041295186,0.051790338,-0.041317195,0.011168218,0.055335507,-0.02921161,0.144495,0.05094567,-0.057457402,0.08213876,-0.028684817,0.05677284,0.042294487,0.038374603,-0.057757165,0.017981553,0.031186212,-0.020606708,0.013030876,0.033636533,-0.026766105,0.033061706,-0.10894585,-0.009707763,-0.009423625,0.049535252,0.042950764,-0.06489215,0.02812769,-0.03917061,0.0022608747,-0.05977145,-0.00965123,-0.0037877199,-4.4023103e-08,-0.034087285,-0.063151926,0.011466774,-0.023876086,0.014091673,0.029905457,-0.0269548,0.027445508,-0.029869769,-0.022204578,-0.0034191986,0.020335423,0.056431867,0.006534287,0.011426301,-0.046669148,0.0523916,0.094016634,0.006187649,-0.007476526,-0.12041769,0.04492943,-0.12247124,-0.036593173,-0.009006128,0.016527817,-0.020567952,0.080262534,0.050576687,-0.06563209,0.10227986,-0.041252088,0.03586291,-0.0068447087,-0.08689232,-0.033676267,-0.008144349,-0.036881052,-0.0048105656,-0.015786894,0.003985143,0.0042067477,-0.05566464,0.020660946,-0.03380765,-0.052889638,-0.008197282,0.105318524,0.004946606,0.042621862,0.044034805,-0.056860298,0.04934612,-0.10564718,0.0032740722,-0.05543058,0.075304694,-0.009877464,-0.049714923,-0.050006505,0.017210234,-0.09151012,0.1582674,0.05429911 +2.1.1.84,"The enzymes from Chrysosplenium americanum also methylates 3,7,3'-trimethylquercetagetin at the 6-position. Does not act on flavones, dihydroflavonols, or their glucosides.",384,1.0,0.009209649,-0.0746229,-0.11821404,-0.007857268,0.036345974,0.0888386,-0.011357803,-0.06460962,0.023211192,-0.08552573,0.0078988895,-0.020622512,-0.098899364,-0.06901862,-0.089487456,0.016263677,-0.11021182,0.011662988,-0.0459169,0.006434941,0.06841503,-0.061635904,0.067433484,0.062210523,0.01463535,-0.004308521,0.024741517,-0.018650811,0.04360611,-0.056696977,-0.021784727,0.027179465,0.056888543,-0.008628254,0.026607959,0.078092664,-0.006695808,-0.04040222,-0.01761442,0.045371518,0.040335838,-0.0350903,0.020934239,0.00035067624,-0.07443832,-0.0679231,-0.006238589,0.0044174627,-0.0017054129,0.06295913,-0.026448408,-0.021303998,-0.025757324,0.09626398,0.034644373,0.0060581416,0.004875846,0.023142248,-0.031983502,0.0024385215,-0.010920373,-0.030716112,0.032390006,0.019145524,-0.04013156,-0.020039698,-0.062043026,-0.05387819,0.033707418,-0.047734268,-0.008090545,-0.027698668,-0.0396501,0.101127975,0.020205393,0.15165104,0.052642,-0.049742296,-0.039019495,-0.06157821,-0.008180223,-0.061006762,0.062189735,0.034953523,-0.025078924,-0.024866609,-0.053425714,-0.0110395085,0.06453084,0.08749416,0.04303474,0.040689826,-0.034818877,-0.041987572,-0.08682512,0.11874258,0.070505366,0.012993413,-0.019839318,-0.011628224,0.04758118,-0.010032833,-0.10635407,-0.020575725,-0.060009923,0.021701613,-0.011102722,0.0016018722,-0.032659072,-0.05648221,0.0067307693,0.0380344,-0.0007571718,-0.029647648,-0.025448782,-0.017045109,0.015990807,-0.12656397,-0.009917399,-0.0933345,-0.019094931,0.048929024,0.030711139,0.022335805,-0.056606714,-0.037204873,-0.09096191,3.6706854e-33,0.047486067,0.0888204,0.030682134,-0.04360982,0.021661311,-0.028394068,-0.02913707,0.01152093,-0.040838864,-0.11217806,-0.05067556,-0.019556222,0.0037618894,-0.08123244,0.016157812,0.017994594,0.018504702,-0.044169657,0.026051885,-0.029422574,0.046556503,0.0025417483,-0.07077694,0.02388741,-0.035649132,0.013580021,-0.021627545,0.028222328,0.057839125,-0.028804217,-0.06791811,-0.012871448,-0.026717363,0.05664952,0.058460455,0.08782398,-0.052979916,-0.031732075,-0.027170049,0.08412807,0.068862356,0.012306986,0.008522477,0.017492643,0.052096236,-0.03981441,-0.07627853,0.09492083,0.042303026,0.045406137,0.02951138,0.05488195,0.17495412,-0.040196814,-0.025482807,0.008505519,-0.012407022,-0.027390542,0.037052825,0.033128385,-0.043604918,-0.0019731058,0.018661372,0.014983924,-0.03819241,0.0048724758,-0.03147207,-0.023780087,-0.0081028575,0.122188225,-0.039701182,-0.03296579,0.07986603,0.08259331,0.08820966,-0.0049399766,-0.060663972,-0.08049653,0.026254281,0.025312753,-0.023021195,0.013172897,0.050363284,0.012409395,-0.05792615,-0.027324852,-0.051642384,-0.0055811736,0.045873556,0.023908334,0.0402831,-0.09212123,0.026781926,0.047818672,-0.06101306,-4.023894e-33,-0.004642338,-0.07425117,0.07583336,-0.011008616,-0.014219375,0.02549163,-0.021919528,-0.009299982,-0.015639912,-0.07080949,0.13937192,0.0011449585,-0.02421135,-0.024444323,-0.009399425,0.0019279313,0.096568346,0.05545393,0.008684416,0.0065424573,-0.030926177,0.030166507,-0.11033623,0.08503623,0.005204862,-0.0011310708,0.026149172,-0.013624922,0.08149123,-0.005424246,-0.01728021,0.029730774,-0.033086553,0.021633316,-0.04162495,0.07118078,-0.05452548,0.008436494,0.024229135,0.037328523,-0.012405053,-0.020553064,-0.016245699,0.08986788,0.028855873,0.06643878,-0.11404107,0.046328913,-0.03167281,0.04372925,-0.011166197,0.032152023,-0.06503738,0.06838777,0.060589444,0.029901288,0.048538513,-0.026644522,0.015349931,-0.028605,-0.053149763,-0.022151647,0.008419588,-0.0051722573,0.011724212,0.093766496,0.0048750066,0.11544599,0.017219666,-0.028814927,0.08243831,0.03436668,-0.0015265227,0.0072924746,-0.0062425854,-0.027485069,0.026567113,0.028411992,-0.02403192,0.015688669,0.084743835,0.0007753226,0.033588782,-0.08183351,-0.025780277,-0.016737929,0.008292925,0.10733862,-0.041736726,0.045116045,-0.009009146,0.021977728,-0.06880332,-0.009707067,0.038932644,-3.5326945e-08,-0.015082478,-0.050320376,0.014562799,-0.021410577,0.004721019,0.031039575,-0.04428036,0.023937257,-0.006087168,-0.038584962,-0.06882613,0.015129839,0.05195134,-0.0047861403,0.0079127,-0.061920043,0.016309239,0.08723308,-0.016853778,0.012490037,-0.103689276,0.09667224,-0.13191578,-0.00043939464,-0.0089282235,0.021654047,-0.022582488,0.05301163,0.024873214,-0.006391571,0.08306958,-0.016632902,0.024055822,-0.002188556,-0.08589499,-0.0061861784,0.008212874,-0.035681494,-0.047539536,-0.0009406513,0.014218141,-0.020335834,-0.004765531,0.025889518,-0.057443313,-0.055676308,-0.07188464,0.086050734,0.03956801,0.056601364,0.033138733,-0.06319818,0.0060882363,-0.11939649,-0.008614518,-0.03590138,0.041073043,-0.051562943,-0.048673615,-0.109355085,0.0073606707,-0.078509435,0.18831816,0.05093377 +2.1.1.85,"Highly specific for histidine residues, for example, in actin.",384,1.0,-0.028449519,-0.07180461,-0.09582299,-0.061012626,0.06325573,0.0070338612,0.086267,0.14660448,0.00391453,-0.0007176235,0.059982833,0.022078907,-0.06219799,0.11462553,-0.056738436,-0.08400054,-0.05270514,0.005116389,-0.0501496,-0.012548608,0.047886685,0.07437737,9.3549264e-05,-0.002794602,-0.0644739,-0.08056208,-0.018533643,0.04037579,0.034960076,-0.05243249,-0.042189844,-0.00040066,0.09839103,-0.030545719,0.09975435,0.060059074,-0.06278547,-0.0052156714,0.033246607,0.0006130908,0.08806767,0.049987644,0.012894963,-0.0073130634,0.016183319,-0.0061141355,0.0067424295,-0.006623325,0.02966693,0.11626781,0.0054200613,-0.026380429,0.025251148,0.05222161,0.037522867,-0.0853323,-0.08364485,-0.006668422,-0.015177145,0.035824116,-0.030856611,-0.030413402,0.03895395,-0.05216782,0.032801785,-0.019467948,0.10952486,-0.102696285,0.012301937,-0.012501581,-0.02559333,-0.058106665,-0.0055305483,0.13413751,-0.010909572,-0.0020762933,-0.06739325,-0.04272444,-0.052619126,0.003912456,-0.06647284,-0.0188414,0.011968359,0.05048789,0.031212756,0.05926619,-0.030123062,-0.013776504,0.0453256,0.043378457,0.011074795,-0.027642496,-0.03635093,-0.08887743,-0.014515964,0.021205982,0.02067576,0.034861922,0.013290001,-0.026126748,0.057422888,0.0023704723,-0.095285416,-0.020093238,0.007467022,-0.012650395,-0.007290518,-0.019969989,-0.06295125,-0.003715935,-0.0021974682,0.006906456,0.080294706,-0.0416744,0.04723609,0.02706898,0.024171794,-0.0317177,-0.0059580547,0.025672529,-0.0006938309,-0.006057488,0.035763808,0.08148834,-0.027557045,-0.0010035492,-0.081493124,-2.5803069e-33,0.052540172,0.030399404,0.025327412,0.050151277,-0.038738687,-0.018843256,-0.08038187,-0.006980245,0.07286104,-0.052131563,-0.076355755,-0.020841468,0.07441351,-0.026906367,-0.083581634,-0.030361371,0.0029682622,-0.025992485,0.09077454,-0.03708822,0.034701314,0.12229017,0.011934479,-0.04287188,0.04005955,0.040169217,-0.05334158,0.0038649216,0.04543154,-0.021720724,0.0053011095,-0.00934623,-0.06261856,0.06133147,0.06891135,0.05203303,-0.105350904,0.0055147875,0.0036515465,0.053646635,0.081125855,0.012788858,-0.0082279295,0.034866747,0.058710173,-0.012288118,-0.04762815,0.068757884,-0.0067891865,-0.020378383,0.0326123,-0.039429214,0.08805263,-0.09523956,-0.03931486,0.048000466,0.0007236999,-0.056965087,-0.0010602077,0.11120775,0.03870196,0.008072363,-0.06259825,0.08402894,-0.019563174,0.014881463,-0.124313064,-0.05892274,0.0020843805,0.0010649356,-0.02921194,-0.028728046,0.096436,0.018723994,0.036623813,0.025263965,-0.07876433,0.06921983,-0.034283865,0.024394998,-0.03994584,-0.018548343,-0.056206003,0.01790881,-0.1294178,-0.02412384,0.09388826,-0.08041286,-0.030272204,-0.043123018,0.028707672,-0.06945825,-0.092280716,-0.048670843,-0.021368803,-9.828435e-34,0.056672,-0.097928606,0.042438712,0.011878536,-0.02124418,0.050256766,0.029894814,-0.0077654524,0.06207917,-0.029594107,0.06254932,-0.052357737,-0.068299,-0.032103278,-0.023769278,0.04493468,-0.055048823,0.06308931,0.035252262,0.0005028781,-0.09918436,-0.0012908838,0.04823688,0.092738874,0.028016435,0.024099773,-0.04367962,-0.071810134,-0.0010200063,-0.007547514,-0.08716912,-0.016984994,-0.09141108,-0.09332715,-0.010564738,-0.041054692,-0.0953805,-0.036179855,0.0088772,-0.07042675,0.041180965,-0.014043177,0.073777795,0.1036518,0.002782297,0.075561546,-0.02356808,0.020673666,-0.0493107,-0.042318445,-0.0327345,-0.035741366,-0.0032691357,-0.044613738,0.0719691,0.073527604,0.019646455,-0.016747693,-0.005426625,0.09026517,0.04763509,0.015824614,-0.051409658,0.022554394,-0.026277373,0.04681458,-0.021173825,-0.057209324,0.049689543,-0.028601047,0.0834216,-0.073347196,0.059620753,0.02584582,-0.10238923,-0.07590226,0.015707625,-0.03431529,0.018649908,-0.03251208,-0.053434826,-0.019259796,-0.08338299,0.035600524,0.0105974,-0.0067322473,-0.03796247,0.008051246,-0.007204365,-0.055582065,-0.006356262,0.01285658,-0.021597397,0.03396665,0.0049809813,-2.01393e-08,0.104676455,0.018241107,0.0140086,-0.07889364,-0.041628934,0.030088691,-0.018761288,0.0001804978,0.018972931,0.04379125,0.057864957,0.048592586,0.035057757,-0.10572241,0.01128151,0.05854953,-0.0929019,0.023568422,-0.017878499,-0.013202907,-0.05376355,0.027837278,-0.055564757,-0.055039596,-0.022754947,-0.013992752,-0.020236341,0.10745352,-0.0017906461,-0.041025475,0.08595883,-0.036234442,0.059195872,-0.06368272,0.0034111955,0.0780253,0.0041097333,-0.08100028,0.033853304,0.010012751,-0.015510063,-0.037628755,-0.023032704,-0.0016439569,-0.016094351,0.021031013,-0.0137565425,0.06976828,0.021343319,0.021597194,-0.010371848,0.05273382,-0.027886473,0.008278252,-0.04676994,0.03164737,0.048610598,-0.08292722,0.046944078,-0.010476136,0.045830417,0.03273384,0.060619757,0.06366185 +2.1.1.86,"Involved in the formation of methane from CO2 in methanogenic archaea. The reaction involves the export of one or two sodium ions. The enzyme from the archaeon Methanobacterium thermoautotrophicum is a membrane-associated multienzyme complex composed of eight different subunits, and contains a 5'-hydroxybenzimidazolyl-cobamide cofactor, to which the methyl group is attached during the transfer. A soluble enzyme that is induced by the presence of CO has been reported as well [6].",384,1.0,-0.018641578,-0.038407292,-0.13061759,-0.01768048,0.04900127,-0.025387146,-0.049395554,-0.00010144518,0.025601862,-0.027516363,-0.017322676,-0.16148183,-0.04651349,-0.010110662,-0.038382735,-0.020282203,-0.05466049,-0.063866004,0.005208663,-0.0184266,0.10161968,0.08708136,-0.04938687,-0.026060946,-0.031538032,0.028983042,0.026091615,-0.06473837,-0.00045806429,-0.0024592034,-0.0087265195,-0.02148497,0.04400098,0.0043610004,0.067995004,0.0980546,-0.0023579653,-0.053651474,0.07179845,0.022703797,0.046168897,0.02651216,0.12498952,-0.039166763,-0.047555994,0.029536445,0.03971785,-0.025786558,0.050012015,-0.07488191,-0.03583065,-0.0690808,-0.0961627,0.039560508,0.0013141392,0.12740612,-0.017728971,-0.04482082,0.031489756,-0.063452154,0.07971696,0.025005238,0.07163647,0.02250736,0.011777391,-0.04098743,0.05251497,-0.074905105,0.067001715,-0.051804043,-0.044671316,0.0041815117,-0.02319215,-0.06996995,-0.064942464,-0.010587232,-0.014211534,-0.04489371,0.08270943,-0.051621083,0.008484309,-0.004085454,0.014090371,-0.039615512,0.0006914929,-0.0031420856,0.06890412,-0.017252741,0.07583928,-0.027885923,-0.03086565,-0.018566905,0.061251733,-0.020873977,-0.11801361,-0.030862516,0.12572198,0.08838365,0.003123824,-0.040130284,0.029617187,0.06468949,-0.02213069,-0.08491653,-0.08208653,-0.044207722,0.07261801,0.12762637,0.03709804,0.08472346,-0.026036672,0.022837026,0.060692787,-0.0040152697,0.057310596,0.06497307,0.0572202,-0.059525218,-0.064508274,0.056414373,-0.012111101,-0.06920684,0.09732659,-0.005570319,-0.03848134,0.046032686,-0.076500624,2.8254199e-33,0.051105656,-0.010970147,-0.045064554,-0.017869877,0.035961147,-0.03606971,-0.08553851,-0.037194002,-0.009639733,-0.032107998,-0.061734483,0.011324761,0.03180294,0.033417895,-0.09361077,0.025852993,-0.054464307,-0.04953933,0.01690297,0.052132133,-0.051171035,0.08667345,0.014800082,0.046306223,0.030059405,-0.032084346,0.006734506,-0.036979273,0.028547691,0.007544828,0.0042130565,-0.11777058,-0.15193841,0.020335626,0.08213772,0.054736298,-0.04321916,-0.011503648,-0.07573048,-0.0023937484,-0.010464908,-0.0075695575,0.0071414374,-0.027242923,0.051573567,0.00106868,-0.05368155,0.14202234,0.025582453,-0.022210654,-0.0690334,-0.007173028,0.051714096,-0.02916904,-0.09399835,-0.02624333,0.03422063,0.009876246,0.039673857,0.047194052,-0.02180903,0.05938622,-0.0042153625,0.13075016,-0.007881465,0.04230531,-0.028342078,-0.023625357,0.10773348,0.03492851,-0.053637862,-0.035044767,-0.0022923846,0.08690225,0.009163223,-0.067342,0.015874228,-0.09535306,-0.0008458101,0.04009673,0.015120833,-0.06060974,0.105651066,-0.05699021,0.005267202,0.011567774,-0.09179941,-0.022096943,-0.03527136,0.080031306,0.02585418,-0.029881814,0.015792876,0.014906761,-0.0046204873,-3.763654e-33,0.053027164,-0.06928452,0.01707859,-0.12927765,-0.06923065,0.083916135,-0.020938722,-0.043191653,-0.0036794855,-0.0463376,0.10274849,0.019786421,0.05762606,-0.042872395,0.0493922,-0.027717203,0.04323105,0.037397478,0.05117662,-0.013862402,0.08488087,-0.016024789,-0.030538568,-0.011023607,-0.0039011524,0.017072702,0.008415647,0.015354679,-0.012416238,0.012378811,0.012751606,0.011611942,-0.03679495,-0.046909757,-0.123064116,-0.020911105,-0.040739276,-0.030739743,0.023181478,0.0010777627,0.007022248,0.00803348,-0.011269941,0.020282777,-0.0026566654,-0.015985807,-0.06548537,-0.050304648,0.019265432,0.023574192,0.010121625,-0.107579544,-0.055026412,-0.060342338,0.007952619,0.07587786,-0.0063457843,0.05549133,0.017866988,-0.018752066,0.014902141,-0.016714063,0.046914443,-0.040285066,0.057789933,0.017684126,-0.012442722,0.030111648,0.004641879,0.046639968,0.036161065,0.039515827,-0.00640029,0.05700851,-0.010475885,-0.047244437,-0.05280961,0.002712456,0.015018226,-0.059353936,-0.017157724,0.016697612,0.10709802,-0.03467334,0.062112905,-0.060747392,0.0723061,0.017818376,-0.02195063,0.051997177,-0.019817108,-0.029368509,-0.053740315,-0.005236237,0.021961752,-3.9662098e-08,0.029290492,-0.015172537,0.056781895,-0.035287548,-0.006170446,0.103565276,0.001563329,-0.014135092,0.04264471,-0.038698938,-0.009755777,0.06095764,0.06282541,0.04761107,-0.044162206,0.0643251,-0.056207635,-0.016984062,-0.016398933,-0.078784294,0.014069238,-0.08963826,-0.0039891955,0.06605297,0.029080037,-0.01475956,0.031488985,0.10195494,-0.036528792,-0.05541493,-0.0769141,-0.00048288715,0.005985486,-0.050451644,-0.04066594,0.018597662,2.5260445e-06,-0.038117163,-0.062237155,-0.015225849,0.027811132,0.044582527,-0.026025092,0.021856159,0.07377483,-0.0011065203,-0.038948197,0.05686491,-0.0015457752,0.03831514,0.07134371,-0.021127159,0.03728715,0.0053159436,-0.042498566,-0.03414047,-0.020100407,-0.030341636,-0.03223569,0.0356221,0.058564957,0.026955089,0.07748113,-0.05572096 +2.1.1.88,"Also acts on 8-hydroxykaempferol, but not on the glycosides of 8-hydroxyflavonols. An enzyme from the flower buds of Lotus corniculatus.",384,0.99999994,-0.05311859,-0.07846794,-0.01934297,0.025707666,-0.021665934,0.080687106,-0.058330327,-0.020114394,0.027963651,-0.07126038,0.042260524,-0.032983035,-0.083962336,-0.028584113,-0.071706526,0.047708184,-0.027229637,0.021170886,-0.07417205,-0.0050661103,0.04585707,-0.012308783,0.028545633,-0.010432907,0.035613935,0.016376058,-0.0129398545,-0.027512122,-0.012860079,-0.08268314,0.027367366,0.09426812,0.025930338,0.038988546,0.004510099,0.093241274,-0.018125761,-0.07639578,0.13867109,0.025642762,0.060269434,-0.08583473,-0.029395325,-0.03572883,0.022607492,0.03896475,0.011574581,0.025364239,0.045486365,0.03152433,-0.039715026,-0.07082403,-0.042938247,0.017326845,-0.031623226,-0.010594027,0.038768116,0.102302566,0.008316225,0.114508994,-0.04027117,0.034024023,0.017557308,0.098318174,-0.10889102,-0.05007362,-0.04717193,-0.02295561,-0.01984535,0.014401669,-0.007894195,-0.018447662,0.0591949,-0.009753416,-0.042337213,0.05778247,-0.047358725,-0.03633997,0.018263629,-0.07100778,0.02811798,0.02022721,0.095817104,0.08714373,-0.018992925,-0.0372623,-0.04477673,-0.01328831,0.011912182,0.0388012,0.060601346,-0.011515115,-0.030183388,0.008676615,-0.024005968,0.040824194,0.10676537,-0.08028296,-0.02990678,-0.011079246,-0.03659789,-0.046489228,-0.00078169955,-0.024315855,-0.07386074,0.07085274,-0.04282852,-0.06786004,0.011651452,-0.02178227,-0.084774755,0.007489159,0.032784496,-0.06413189,-0.040985268,-0.058137365,-0.020387473,-0.0694975,-0.044013996,-0.056567326,-0.0065699383,-0.09245369,0.07059019,0.077596925,-0.093366414,0.07880174,-0.06845467,1.52246125e-33,0.032631237,0.011197313,0.014641929,-0.06288801,-0.002522154,-0.07951772,0.0047323247,-0.014512906,-0.04611505,-0.036051758,-0.05236964,-0.018156826,-0.022219187,0.05424407,0.0055231885,0.05498493,-0.0441823,-0.052951336,0.09733616,-0.04138194,0.076715395,-0.00012373544,-0.08600324,-0.07780214,-0.07666789,0.043528616,0.02182736,0.0025762143,0.026769865,-0.016128741,0.0053029624,-0.12354079,-0.005012304,0.04253856,0.019720921,0.06834745,-0.031731147,-0.08471636,-0.074558884,0.025055777,-0.0057610893,0.027757417,0.0042065056,-0.04955682,0.04808951,0.045004725,-0.092214815,0.045489244,0.07856738,0.04092133,0.08291105,-0.011122303,0.124427736,0.014263181,-0.037102927,0.085455574,0.00848015,0.010483239,-0.004826241,0.053276718,-0.014388533,0.009769438,0.02408787,-0.07011566,-0.018357635,0.10285818,-0.11818565,-0.02553077,0.0018178805,0.041957036,0.0041236714,0.00845789,0.07407823,0.04990878,0.058379028,0.01948289,-0.029886577,-0.021035213,-0.0020932225,0.045722954,0.0075902087,-0.025402972,0.062082145,-0.032872442,-0.006720614,-0.0014135543,-0.046522085,-0.032411363,-0.062911555,0.019964823,0.075418286,-0.095372096,0.025270512,0.032489635,-0.0018579257,-3.775654e-33,0.022664305,-0.024971448,0.03272522,-0.031172587,-0.025214918,0.05761872,-0.013503079,-0.02453784,-0.015911894,0.06060282,0.001448218,0.03592071,0.017100677,-0.04651234,-0.05779127,0.0051896954,0.018059641,0.1230854,-0.038163077,-0.0059990226,-0.042921785,0.040224105,0.0106491605,0.061753895,0.031239301,0.004922691,0.036238432,0.023765191,0.0010320175,0.04835539,0.02900937,-0.022779597,-0.051595867,0.008232501,0.060304582,0.0054879216,-0.1111417,-0.011306828,-0.0068371044,0.0075913523,0.023650179,-0.0149531495,0.053649124,0.051230986,0.07437872,0.07731664,-0.09893794,0.037717514,-0.046666894,-0.0016919987,-0.05058621,0.050184097,-0.032589257,0.05969399,0.04429323,0.05356052,0.028690398,-0.010851105,0.013945509,-0.06674219,-0.024836063,-0.074982084,0.009897552,0.004101785,0.06953586,0.11189289,-0.016702725,0.07243046,0.022036245,0.016931918,0.07759843,-0.019983873,-0.026624208,0.074949555,-0.0011452745,-0.002636036,-0.021675413,-0.06346345,-0.024582671,0.023779012,0.04124651,0.009514195,0.009626053,-0.10572251,-0.00839786,-0.069937944,0.00678243,0.06317358,0.036724888,0.051941607,0.014823852,0.02320918,-0.036227196,-0.04574576,0.07640749,-3.0494153e-08,0.0026634855,-0.08121765,0.07372626,-0.06819694,0.002018564,-0.030509992,-0.049995188,0.0028082007,0.03362378,-0.0559154,8.779833e-06,0.021945335,-0.023840832,0.00831922,0.019292962,-0.06550163,0.054527596,0.046631176,-0.022969875,-0.0046821055,-0.1025377,0.02059403,-0.06494471,0.05865276,-0.010205589,-0.10234686,-0.015428039,0.046650585,0.05019385,0.030070033,0.0199414,0.09831012,-0.06867788,-0.032472663,-0.07484982,0.07434863,-0.024564104,-0.009165969,-0.047291122,0.016910085,-0.04109458,-0.08497813,0.020429157,-0.0015510162,0.026389522,0.027017096,0.021908127,-0.014111225,0.044612918,0.030411918,0.027015293,-0.010804774,-0.0042386116,-0.077929,-0.12402294,-0.03637827,-0.029003808,-0.001003924,-0.005583538,-0.101442024,-0.048305344,0.028742291,0.2139907,0.009921883 +2.1.1.89,Involved in the biosynthesis of the berberine alkaloids.,384,0.99999994,-0.09090532,0.011026695,-0.0911467,0.0013208243,-0.06688003,0.091687486,-0.08030689,-0.0024405776,0.059453588,0.032438245,-0.0065511228,-0.041795276,0.022165308,-0.09182278,-0.067797,0.079328336,-0.06925689,0.0978911,-0.06573004,-0.018902034,-0.020270439,0.048861112,0.03419529,0.009600786,0.04812065,0.038393322,-0.051775042,-0.04455288,0.036180522,0.015434865,0.0798381,0.067069486,0.04291321,-0.050835665,0.00503028,0.06615863,-0.016281594,0.032736823,0.1185029,0.0753805,0.05176596,-0.021401875,-0.038153708,0.026438374,-0.05748039,-0.06396511,0.030718356,0.032696906,0.010178478,0.039727416,-0.0439613,0.0064320434,-0.0736471,0.0024611275,-0.00444443,-0.06391141,0.08529646,0.08899498,-0.010848348,0.041162133,0.04213851,-0.0046308273,0.021979539,0.030488264,-0.04231349,-0.025255997,-0.026518444,-0.06692617,0.052722685,-0.03988896,-0.007452918,-0.087732665,-0.049468987,0.02434829,0.0111450115,0.0452933,-0.01748281,-0.058786232,-0.09474162,-0.00047739162,0.014592271,0.036790606,0.059386425,0.029301321,-0.010873694,0.01762799,0.066329226,0.09853424,-0.019800717,0.00042737747,0.086988576,-0.0287046,0.00862462,0.00083218707,0.0022757433,0.008709936,0.062563725,0.047153164,0.016081296,-0.07210395,0.04738599,0.0017700334,-0.10095972,-0.07886763,-0.025742026,0.0019435748,0.0143034365,-0.037826497,-0.072782725,-0.018534686,0.04345226,-0.017248265,-0.039661136,-0.0026166223,-0.05904304,0.0870131,0.07227955,-0.051012613,-0.02037622,0.061304722,-0.034836277,0.033989362,0.09893729,0.025176222,-0.052498206,-0.030422356,0.00042686926,-2.995995e-33,0.0070003197,-0.018938197,-0.00499445,-0.03604895,0.07096939,-0.0033579587,-0.06832098,-0.059748337,-0.004181324,0.0067441873,-0.03865089,-0.014011498,-0.01794124,0.012885625,-0.050767493,0.006781354,-0.044399448,-0.076445036,0.024721662,-0.068369776,-0.02213266,0.057901036,-0.06427732,0.04465812,-0.04044249,0.07738981,0.044846114,0.01364232,0.0016974686,-0.041332535,-0.023599736,-0.124759264,-0.056856778,-0.058680672,-0.069809556,0.0013448563,-0.050794624,0.022948513,-0.009475383,0.089890786,0.05376836,0.013963959,-0.00921833,0.004403273,0.068513654,0.019920984,-0.01577343,0.020138606,0.032069672,0.017889466,0.03301893,-0.0046234727,0.08912822,0.09899926,-0.06290457,-0.030159062,-0.055545006,-0.017996592,0.003475568,0.10915417,0.012166957,-0.00082069635,0.053366583,0.0078043444,0.017863136,-0.06842619,0.027960375,-0.025687205,0.0029884367,-0.0029620682,-0.014359077,-0.056917466,0.064790145,0.031611003,0.008178625,0.020548256,0.022439763,-0.045342356,-0.039049894,0.016072001,0.024302924,0.041572895,0.041930947,0.047863655,-0.111940786,-0.021229744,-0.041744757,-0.03396106,-0.11318556,0.039503656,-0.08901714,0.06965083,-0.10000746,-0.009764457,0.018455619,-3.036204e-34,0.09507553,-0.04843445,0.052149344,-0.06523803,-0.08745784,0.037028395,0.023023516,-0.020178514,0.015408628,0.069122694,0.0073870635,-0.015884656,0.057934877,-0.013735923,-0.0556604,-0.07729465,-0.0062212176,0.10491556,0.015321176,0.04554572,-0.08976273,0.07172539,-0.061999943,0.030274551,-0.0060542948,0.031457674,0.027737064,-0.015101459,0.038809396,0.108850755,0.096448295,0.009802025,-0.08741463,0.033398222,0.036654606,0.089622974,-0.048617516,0.028462524,-0.024127332,0.0014325371,-0.016619366,0.018298492,0.06624475,0.00037871607,0.10748806,-0.019677771,-0.028416658,0.03566075,-0.09858695,-0.061700594,0.059016254,0.080354266,-0.008851053,0.04755034,0.08563038,-0.00011280845,0.0015397075,-0.039262712,0.07542096,-0.016994514,-0.031264953,-0.022573346,-0.010699882,-0.058995727,-0.026746837,0.07402641,-0.032363,0.0026874917,0.064534,-0.021634657,0.10000494,0.04698342,0.0010375638,0.06448943,-0.03714313,0.08294362,-0.03187668,-0.039918747,0.013904854,-0.044476334,-0.026799904,0.011349127,0.006743899,-0.08953226,-0.048740864,0.018345997,0.018059334,0.015467769,0.053035077,0.009031273,-0.00092005904,-0.11096,-0.12317217,0.034813352,0.019457946,-1.736677e-08,0.019704456,0.005784723,0.09487716,0.07235214,-0.0773952,0.007958405,0.019261299,-0.010748596,-0.025475658,-0.04284615,0.00020936255,-0.042201616,0.010582526,0.092524186,0.039556637,0.04428732,-0.029714819,-0.0008586259,0.027036494,0.0072137965,-0.071605176,0.018111408,-0.028268026,-0.064516656,-0.051363617,-0.086819835,-0.0116328215,-0.011618382,0.0023355798,-0.032299943,0.11772976,-0.03304598,0.023315707,-0.061805647,-0.018015072,-0.050958212,-0.046308614,-0.053361524,0.059288714,-0.04106323,-0.0853163,-0.06769387,-0.0032536692,-0.025811031,-0.056274433,-0.05576729,-0.0025827526,0.06457441,-0.018925583,-0.013793171,0.07897543,0.013354557,0.04652307,-0.07929151,-0.036884375,-0.021436136,-0.02909087,-0.008033188,0.01806903,-0.11320889,-0.063013405,-0.0019101569,0.11878677,-0.033064377 +2.1.1.90,"The enzyme, which catalyses the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. Free cob(I)alamin can substitute for the corrinoid protein in vitro [2]. +Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.",384,0.99999994,-0.04074333,0.0064539295,-0.13186409,0.0152954245,0.07110734,0.02343581,-0.06930749,-0.05637553,-0.01818088,-0.056338448,0.003836994,-0.058528442,-0.066635355,-0.042845003,-0.0129735675,0.038036354,-0.046687733,-0.011128368,0.0055732527,-0.034210406,0.050411463,-0.008648469,-0.08514333,-0.016297145,-0.019437723,0.03867659,0.03585425,0.015108008,0.025170887,-0.005169172,-0.013916936,0.03596426,0.004895042,-0.031354573,-0.012458299,0.11638195,0.035167117,-0.08035426,0.049342487,0.021494437,0.039224483,0.052955568,0.09088563,0.01912973,-0.0132244555,-0.059235677,0.02082147,0.011135367,0.0011567397,-0.08600265,-0.03637769,-0.06798365,-0.059653703,0.03246146,0.04882609,0.086443536,-0.07549358,-0.035949893,0.04431685,-0.011628843,0.00849678,-0.0036217384,0.042509533,0.005549578,0.09444445,-0.036508117,-0.0055645555,-0.0994629,0.056188665,-0.07244779,-0.0075023263,-0.029036906,-0.039072137,-0.07093403,-0.04765761,0.01858253,0.008505105,-0.09154566,0.052690774,-0.038274452,-0.027186949,0.09152551,0.05111859,-0.024904678,0.045900356,0.01894095,-0.053362064,-0.015377703,-0.009661383,0.012820264,0.04397602,-0.006250585,-0.022373274,-0.0025296865,-0.084036015,0.004304519,0.1464922,0.054568674,-0.019875418,0.030621154,0.01092729,0.09951119,-0.09446629,-0.018686142,-0.054047704,-0.0019280385,0.11916834,0.120106645,-0.055787474,0.11135398,0.018162113,0.061508767,0.026550686,-0.016589966,-0.0015676782,0.08058978,0.015602638,-0.019882187,-0.01747189,-0.018174091,0.035509754,-0.012204747,0.02636668,-0.03293734,-0.018228728,-0.011292879,-0.014039626,2.5241164e-33,0.06191068,0.035237852,-0.022183267,0.012829608,-0.03706376,-0.06353769,-0.07379301,-0.012977578,0.04739621,-0.05628754,-0.052321468,0.016012827,0.05326282,-0.0016208674,-0.11330379,-0.049297556,-0.05721363,-0.056032952,0.0574198,0.0005513761,-0.023318157,0.09362741,-0.025064692,0.013427827,-0.029290935,0.02070333,-0.06348009,-0.01852304,0.03581987,0.016832948,-0.017743703,2.942606e-05,-0.102810025,0.03441388,0.00072995375,0.01292594,-0.085952066,0.00742911,-0.0066118627,0.043745812,0.05895963,-0.0057202782,-0.049872782,0.011015776,0.0074759983,-0.043747246,-0.046395533,0.064803556,0.01842161,-0.028032254,-0.023312299,0.00834773,0.031492773,-0.05207499,-0.10219067,-0.0319839,0.01586495,-0.08326443,0.0115782935,0.07533698,-0.014215886,0.017668363,0.023115885,0.11038057,-0.009438974,-0.02203527,-0.06705366,-0.09466754,0.08933109,0.036976706,-0.0118327355,-0.0075635016,0.0364344,0.08319339,-0.0015307785,-0.0249352,0.047640644,-0.009055221,0.031651556,0.02029053,0.10585794,0.0011147966,0.060183607,-0.051492367,0.020208994,0.023758681,-0.059315015,-0.053044975,-0.011132646,-0.010451969,0.008608413,-0.012838739,0.024619175,-0.042542286,0.023758529,-4.6451e-33,0.091380954,-0.09236783,0.0744098,-0.12640415,-0.09632763,0.06382787,0.018985126,-0.12674749,0.0055257557,-0.054102458,0.10420481,-0.021002822,-0.0055549196,-0.01350666,0.057856962,0.007496501,-0.06550294,0.10376481,-0.034227207,-0.017510278,0.030306606,0.0679519,-0.021550417,-0.014928391,0.049669594,-0.024753774,-0.062009044,-0.020499874,0.07066341,0.077049434,-0.012942239,-0.055211592,-0.05346359,-0.019086188,-0.0424325,0.056309078,-0.052068442,0.041223787,-0.007900013,0.0010924056,-0.0020123955,0.010695576,-0.012788392,0.047957946,0.06716926,0.044183154,-0.10589872,-0.029735912,-0.013131837,0.03462256,0.037697118,-0.029529126,-0.07854251,-0.06854144,0.054442916,0.09305929,0.051111266,-0.015170974,0.05700597,-0.05536168,-0.057683144,-0.013389057,-6.336137e-06,-0.044249486,0.06962369,0.044826522,0.011268902,-0.0020903884,0.065503106,0.017246636,0.04582665,0.103164695,0.042486362,-0.025014345,-0.020326894,-0.054186426,-0.06410392,0.044914767,-0.05895817,-0.04716037,-0.008602967,0.021711376,0.0640649,-0.021479996,-0.017837018,-0.009295771,0.10269843,0.011961431,-0.038150907,0.024398807,-0.076249845,-0.06063588,-0.042218547,0.010580254,0.0006306693,-4.146272e-08,-0.015909221,-0.047419313,0.048868157,-0.026662856,0.002705447,0.16301464,-0.033336807,-0.08261807,0.08753862,0.022922209,-0.013576761,0.06507896,0.053677868,0.04542581,-0.09176785,0.024276135,-0.07020554,0.010709426,0.003877638,-0.029828578,-0.037961524,0.008709137,-0.0045730365,0.06997733,0.03470328,-0.06314221,0.027211439,0.13842618,-0.023919683,-0.06540283,-0.017548949,0.021586241,0.049070183,0.011450593,-0.037242997,-0.0067098527,0.0213999,0.0138256885,-0.07942303,-0.028135683,-0.007588785,0.010807143,-0.05775842,0.01212009,0.058509,-0.03442782,-0.048680685,0.09451401,-0.022204714,0.04561719,0.04722777,-0.035132922,0.013870251,-0.03731583,-0.036324184,-0.014826418,-0.028960025,-0.03044897,-0.0038323284,-0.019037902,0.031315994,0.008417644,0.1055179,-0.09396377 +2.1.1.91,Oximes of C4 to C6 aldehydes can act as acceptors; the most active substrate is 2-methylbutyroaldoxime.,384,1.0,0.028228037,-0.08105279,-0.043127157,0.0079041235,0.08219682,0.039777413,-0.07434386,-0.012403395,-0.012076376,-0.048094146,0.0749936,-0.0750151,-0.07085404,0.07317673,-0.0395613,0.13607925,-0.05485205,0.02142631,-0.010792095,0.04352801,-0.081204616,-0.029975144,0.014535502,-0.012084755,-0.0115509555,-0.0136979865,-0.045204476,0.026835384,0.02166269,-0.041726433,-0.027051374,0.0448424,0.015030603,-0.01319061,0.040078938,0.04819475,-0.058767214,-0.041581236,-0.00437495,0.012761599,0.030587465,-0.028360995,0.03947499,0.020311922,-0.02225013,-0.05346321,0.06608615,0.05154399,0.03196788,0.022720624,0.027102081,0.002140706,-0.07307191,0.0684979,-0.010281868,-0.02559735,-0.0716879,0.03127676,0.04804117,0.03904212,0.014562605,0.0018828353,-0.044351496,0.015238079,-0.018805873,-0.058191344,0.042069435,-0.022080354,-0.036004934,-0.02335644,-0.07550465,-0.064387195,0.023255121,0.0048574945,0.06231299,0.01138128,-0.059227105,-0.10864813,0.06586601,0.0032222222,-0.038473397,0.051281206,0.057938207,0.03774594,0.089073636,-0.05409685,-0.060681704,-0.00377788,-0.00059721136,0.046846524,-0.0038635696,0.047719967,-0.041248586,-0.036436073,-0.010254831,0.010490654,0.15184732,0.04604201,0.070419475,0.045332003,-0.03821974,0.04251603,-0.11609958,-0.05086795,0.0011727405,0.03160066,-0.024762949,0.06821736,-0.046270266,0.03021028,-0.009408704,-0.03827347,0.01867698,-0.023421356,0.01598727,0.063024685,0.027644245,-0.07244469,-0.058547445,-0.055916503,-0.062613554,0.020197688,0.09290614,-0.01793837,-0.01581594,-0.037177447,-0.054764148,3.3906315e-33,0.045659028,0.007889265,0.04047115,-0.007942198,0.019534105,-0.027822593,-0.07117338,0.03988132,0.019849382,-0.05666789,-0.07307994,-0.051034685,0.04548017,0.038885947,0.05027367,-0.057619076,0.012769812,-0.042539746,0.056778423,-0.02878248,-0.020986103,0.0027472926,-0.05987872,-0.01730026,0.018477622,0.0470251,-0.015532302,0.011494079,-0.0036079884,-0.019167311,0.026208568,0.023857875,-0.09579158,-0.05087673,-0.027789751,0.008917088,-0.059392374,-0.0054912767,-0.009890268,-0.031319913,0.031668246,0.041439015,-0.018419191,-0.03414498,0.052306283,-0.051715113,-0.07027616,0.051519558,0.027976219,0.07499533,0.03550385,-0.079257585,0.01903305,-0.042032856,-0.0601502,0.011100564,-0.05575015,-0.0011954803,0.012540796,0.046153016,0.009322599,0.041530725,-0.008335526,0.021047844,-0.038220886,-0.024148798,-0.021967417,-0.042463586,-0.048030157,0.019156802,-0.03696789,-0.012736058,0.067426905,0.021207651,-0.012199727,-0.04395619,-0.0114082815,0.041849885,0.0727204,-0.03900584,-0.0019113867,-0.012319366,0.052453745,-0.0145864105,-0.06537348,-0.059190784,-0.037909143,-0.026612252,-0.010688564,0.045651235,0.040766645,-0.032676756,-0.047735702,-0.024994401,0.010233729,-5.178655e-33,0.16983476,-0.06675664,0.09132213,-0.07267504,-0.032698918,0.038525987,0.0012081368,-0.044085305,0.04874576,-0.005382356,0.1063915,0.06319966,0.037522767,0.020185098,0.023503672,0.0062312507,-0.0037745407,0.09240941,0.000391834,-0.020017775,-0.012779833,0.038693707,-0.04555704,0.0023371277,0.060610585,0.0028195984,-0.029129673,-0.066534,0.0725851,0.06856172,-0.08186001,-0.0026350755,0.0015574349,-0.03142469,0.06789803,0.054121904,-0.08762356,0.006357497,-0.08535097,0.11115158,0.0647869,0.03434414,-0.05810079,0.12518954,0.017322877,0.01158664,-0.019211423,0.0016343547,0.01192761,-0.06241285,0.0657838,-0.014597049,-0.045750476,0.012273778,0.06790927,0.14960258,0.042440202,-0.13808003,0.018211443,-0.066244364,-0.05844574,-0.027994396,-0.024402719,-0.0967327,-0.01775739,0.023363465,-0.025916822,0.06867323,0.030120777,-0.05730301,0.13110511,0.025526516,0.006018104,-0.0013099061,-0.0007852254,-0.08535176,-0.011376869,-0.012235309,-0.013958605,0.0064293644,-0.012064294,0.06041786,0.055971425,-0.030781971,-0.006210468,-0.04517459,0.041067455,0.015020863,-0.039599285,0.050774086,0.036800098,0.012508648,0.048177928,0.10574344,0.037727553,-3.376528e-08,-0.042138107,0.0062135733,0.09644778,-0.074250355,-0.088241115,0.0631191,0.022488743,0.017172357,-0.016781466,-0.034668487,0.04641551,0.070960045,0.028202124,-0.03927625,0.038909197,-0.040756464,-0.10210213,-0.040248275,-0.076441824,0.050473645,-0.10279396,-0.018497903,0.0078238305,0.022398666,-0.048373625,-0.053506196,0.013878531,0.05105059,-0.020814393,0.016023166,0.045187477,0.047545917,-0.028306752,-0.080799274,-0.03597382,-0.0048784115,0.03855195,-0.11652518,-0.08575915,0.006450197,-0.0012194522,-0.18313327,-0.08132817,-0.012688873,0.06366369,0.018259186,-0.026582042,0.00027786204,-0.020120881,0.032868367,0.07918861,0.0062596197,0.016586298,-0.0052917944,-0.023587152,0.00677577,-0.0017404493,0.011889768,0.0073273033,-0.111449316,0.01069446,0.033246048,0.1767841,0.016099485 +2.1.1.93,"Also acts on 5-hydroxyxanthotoxin, formingisopimpinellin.",384,1.0,-0.040968597,-0.040464416,-0.014139597,0.009327465,-0.0006063482,-0.033688664,0.008843965,0.032677148,-0.008457293,-0.014335109,0.0110850865,0.015499435,-0.024535872,0.073259674,-0.030118339,0.109607615,-0.06399974,0.02605047,-0.007164055,-0.043191556,0.04366045,0.03500236,-0.0011043185,-0.0054489896,0.03750321,0.04650991,0.042040464,0.10103891,0.04692945,-0.018414728,0.011081265,0.054413337,0.030242722,-0.021630423,-0.005513604,0.07189384,-0.081462905,-0.017370181,0.059488963,0.057713088,0.036160678,-0.065765895,-0.02802001,0.009337951,0.005185934,-0.035078514,-0.00752449,0.027156994,0.1055465,0.108723566,-0.04774336,-0.083821155,0.0029678664,0.073562376,-0.010303422,-0.03900617,-0.066788696,-0.0438778,0.03697796,-0.020024644,-0.087503456,0.012793346,0.0066452147,0.021015827,-0.008552971,0.07384792,-0.01911663,-0.05688175,0.03415332,-0.06545044,0.047655344,-0.011304323,0.059924953,0.052098736,-0.11641051,-0.0011340645,-0.035935808,-0.074316576,0.00053240673,0.0318302,-0.052532166,0.041167576,0.041004743,0.077785954,0.036151562,-0.06583955,0.0060903323,-0.027169565,-0.06828676,0.029096743,-0.016081544,0.025506537,-0.01649098,-0.0058986996,0.024878617,-0.054312397,-0.053597484,0.05816043,-0.06733006,-0.024677282,-0.033908457,-0.015242441,-0.079356335,-0.071026236,0.031941712,-0.009490369,0.013716855,-0.044970416,-0.014215479,-0.07028609,-0.06817176,-0.016384874,0.023021072,0.009445934,0.022794724,0.07947744,0.028309988,-0.017522562,-0.0733006,-0.025165781,0.020806452,-0.020921282,-0.0012021788,-0.03238989,-0.07955858,-0.029541919,-0.005339657,9.667204e-34,0.045725893,0.056275483,0.00017937727,0.124953866,0.029147172,0.042098686,-0.03167736,-0.031095004,-0.009817,-0.044594448,-0.05628202,0.012618469,0.027394203,0.047226667,-0.0062815677,-0.06149092,-0.044925954,0.025313161,0.057019766,0.0055869934,0.0071402034,0.08768631,-0.060420983,0.001243404,-0.11615972,0.13924061,0.009875617,0.020639861,0.01925483,-0.01026756,-0.04838245,-0.008290687,-0.051219072,-0.0044344645,0.006585857,0.08976468,-0.020030465,0.011270571,-0.052640747,0.07268622,0.023976691,-0.028500453,-0.09048803,-0.06476478,0.08157427,-0.04691741,-0.1146509,0.037991516,0.051064923,0.024860537,0.09005726,-0.057135172,0.06535004,-0.03195929,-0.045791138,-0.017532514,-0.025836634,-0.014074956,-0.017038463,0.05620287,0.052473787,0.002886313,-0.007635238,0.04335871,-0.027791727,0.039653074,-0.005995892,-0.046126775,-0.070719086,0.020125646,-0.022648133,0.06452726,0.07619879,0.046101827,0.02031047,0.015298105,-0.014813233,0.005584789,0.04296577,-0.0065079043,-0.027964523,-0.070496306,0.0680232,-0.018728733,-0.06521207,0.008953255,0.047353502,-0.05976146,-0.055411734,0.050571658,0.04801715,-0.15479049,-0.08463435,0.032131724,-0.021385243,-3.4465965e-33,-0.011774508,-0.09743962,-0.024488453,-0.07188321,-0.048689686,0.11800087,0.042550873,0.023635434,0.013793592,0.03999395,0.0718214,-0.03633529,-0.08794419,-0.00893188,-0.0014082362,-0.011972937,0.06503025,-0.014361409,-0.070277765,0.021024223,0.02748928,0.054286078,0.027112862,0.1188849,0.082452536,0.1004083,0.049979072,-0.050321493,0.053436257,0.06848469,-0.06251526,0.00043043427,-0.040787008,-0.055612396,0.031285893,0.08566483,-0.053805735,0.012378188,-0.039106607,-0.1066546,-0.027383529,-0.087239295,0.044062685,0.09211887,0.0024627734,0.055108484,-0.02606886,-0.021162229,-0.065892726,4.750104e-05,0.009275591,-0.01389986,-0.024117846,0.05333089,-0.022026805,-0.004870815,-0.059012596,-0.05305649,0.06007777,0.0038666308,-0.0013084584,-0.015006828,0.0067997244,-0.035391506,0.03447309,0.034391947,-0.00011853516,0.017813066,0.05334078,-0.0032001212,0.1073311,-0.00089787954,0.045978975,0.02556357,-0.07369236,0.004249661,0.046903033,-0.022735912,-0.014274764,-0.034896757,-0.032682322,-0.038288645,-0.0039800727,-0.0015078972,-0.0816026,-0.07607906,0.003980052,0.050069463,0.012845104,-0.012357159,-0.019641444,0.065569684,-0.12168532,-0.06716728,-0.010787889,-2.4569061e-08,0.030804344,-0.0716549,0.08947624,-0.053513534,-0.030285649,0.015632082,0.051052965,0.036476787,0.07909186,-0.05401826,0.017138958,0.07557275,0.07533015,-0.027414575,-0.027027806,-0.034955733,-0.050710607,0.06014902,0.020985246,-0.0293675,-0.12476517,-0.056271628,0.019882543,0.0077176234,-0.017583724,-0.0927551,0.030105067,0.056587063,0.07636329,-0.02291349,0.06141972,0.023233097,-0.027849846,-0.029060803,-0.06253406,0.11414135,0.02348344,-0.011413934,0.028792126,-0.00768691,-0.09861708,-0.053114936,-0.031503245,-0.011338606,0.011257908,-0.041359447,0.015355676,0.0021307461,0.039729565,-0.04075273,0.0035720735,0.017716134,-0.0031262704,-0.025360232,-0.10505441,0.03589714,0.019019963,-0.08355655,0.06941677,-0.073746935,-0.052304022,-0.04059331,0.14119706,0.11155888 +2.1.1.94,"Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus.",384,1.0,-0.053688202,0.01290166,-0.12845415,-0.067357875,-0.05206693,0.068369985,-0.094934896,0.036054563,0.02704277,0.01607693,-0.0010763627,-0.021781137,-0.007735144,-0.05471042,-0.079115815,0.07134606,-0.071304895,0.06249156,-0.022706522,0.023401069,0.032110583,0.06340456,-0.004382394,-0.011511724,0.017385202,0.03117751,-0.020308504,0.0012370114,-0.05455682,-0.056452475,-0.002054962,0.007858712,-0.04916491,-0.08938793,0.01221325,0.035051055,-0.026631365,0.005582034,0.116297215,0.091786936,0.016291294,-0.012345309,-0.084098145,-0.020925121,-0.0038096465,0.007540288,-0.01046991,0.022667887,0.07880198,-0.06779926,-0.0873407,0.008995038,-0.070803314,-0.0562942,-0.052104916,-0.076009035,0.039439805,-0.004760943,-0.02970251,-0.023830924,-0.011552649,-0.0022983588,0.052750546,0.0065489192,-0.0365364,-0.048564717,0.009360737,0.017636493,0.056071658,-0.096612565,-0.0054288637,-0.041941416,0.013352392,-0.03575801,-0.102297015,0.05232505,0.00552604,0.058149286,-0.009412066,-0.02700655,-0.04840438,0.0007579576,-0.010608985,0.08637469,0.05322284,0.05018409,0.06067429,0.03466242,0.03629447,0.09458486,0.028031414,-0.010248761,0.047343597,0.0059955455,-0.05654934,-0.0030271814,0.043401685,-0.04190959,-0.0001874045,-0.047855027,0.030755546,-0.03349199,-0.019369991,-0.026224498,-0.057312362,0.048282117,-0.010987836,0.061697956,0.030413173,-0.043617543,0.005827043,-0.0024480943,-0.016034594,-0.004764332,0.018788766,0.079097226,0.050913688,-0.021775093,-0.0047135786,-0.025641806,-0.021386577,-0.012092034,0.011175598,0.017624095,-0.01953685,-0.022942541,-0.054207142,2.7317456e-34,0.060967546,0.06556686,-0.0026161422,-0.07030594,0.062066574,0.0006695244,-0.17540543,0.029875608,-0.03358424,-0.029186696,-0.100032896,-0.118916646,-0.013338804,-0.021260401,-0.050409395,0.045431316,-0.018832093,-0.042940736,-0.017214121,-0.007575682,-0.02152403,0.0204765,0.021992845,0.006317424,-0.024520809,0.04554568,-0.005822713,-0.052476685,-0.064892635,0.009938357,0.03511427,-0.203592,-0.0013789652,0.018381793,-0.009015247,-0.010707158,-0.016464602,-0.08384967,0.018901585,0.060596846,0.0077843852,0.018439557,0.028522618,0.008598344,0.03137179,-0.04259276,0.029698424,0.17461257,0.02224064,0.024907753,-0.04256005,0.025341267,0.18237947,0.026363863,-0.11511416,0.014971277,-0.022875609,0.016394159,0.04694933,0.05488462,0.04171035,0.04308096,0.03200072,0.011909134,0.025250787,-0.009188205,-0.032151077,0.019428065,0.08024545,-0.018398874,-0.048368268,-0.008584081,-0.002718588,-0.03263616,0.083422065,-0.059651457,-0.013517402,-0.025197046,0.03903666,0.021345718,-0.020871082,0.02912847,-0.04657028,-0.012422154,-0.011426725,0.06854478,0.056666475,0.0068111713,-0.028581241,0.0844253,0.037485372,-0.032086894,-0.029633384,-0.034507383,0.08105282,-1.2773628e-33,0.014869094,-0.035528176,0.016302692,-0.03908481,-0.02215468,0.05549048,-0.08077989,0.052249894,-0.028688138,-0.05049613,-0.05279274,0.015744245,0.062154375,-0.035706617,-0.039617278,-0.0007455626,0.026393734,0.09868831,0.042201858,-0.080303214,-0.013507725,0.028305786,0.004750175,-0.0012131184,0.026235266,-0.022192338,0.00090256863,-0.015454542,0.008513457,0.07251772,0.060959425,0.06421199,-0.085596256,-0.044485047,0.01124053,0.085663654,-0.039382406,0.08348983,0.066973686,0.06971522,0.01975676,-0.013414293,-0.03222029,0.023893341,0.008130819,0.021538187,-0.043171335,0.05876735,-0.04460695,-0.01096638,0.077255115,0.02379069,0.07851742,0.025239863,0.056508854,0.00089009135,0.019374534,0.024537107,-0.022927634,-0.045393936,-0.051837243,-0.060418997,-0.009630915,-0.013414941,0.0126137575,0.061956387,0.017909274,0.020665042,0.09844841,-0.051713433,0.061904088,-0.015464968,-0.01269599,0.06749721,0.024954036,0.03595288,-0.058027063,-0.066876,0.011019462,-0.0010241091,-0.014917722,0.003152813,0.034252282,-0.10841521,-0.08681152,0.032951865,0.029769095,0.058345053,-0.035977427,0.020097507,0.018397063,0.028947778,-0.091806784,0.018072482,0.04009658,-2.4751964e-08,0.09869316,-0.026793055,0.078130305,0.035287004,0.0011621773,-0.009997737,0.043559935,0.04722542,0.010152538,0.0004930546,0.031899408,0.05695863,0.050676968,0.008343492,0.06346366,0.06287594,0.102519326,0.0149667505,-0.012782683,0.028267931,-0.0713658,0.024792131,-0.046990994,-0.029482579,-0.013260955,-0.097458854,0.00538345,-0.039009158,0.010777251,-0.051282607,0.06673478,0.0021587336,-0.01834146,-0.16289398,-0.06937962,0.006941002,-0.02431303,-0.073421925,0.06216145,-0.05446116,-0.006943271,-0.04073301,0.01895904,-0.0019330138,-0.033370685,-0.009026931,0.020393215,0.0458452,-0.03563212,-0.07963801,0.019216452,0.033239085,0.075597644,-0.10609575,-0.14794827,0.048345774,0.048954986,-0.05729113,0.032051504,-0.05446915,-0.027743818,0.04026821,0.119388506,-0.09581536 +2.1.1.95,The enzymes from plants and photosynthetic bacteria have similar efficiency with the gamma and delta isomers of tocopherols and tocotrienols.,384,1.0,-0.101523295,-0.075225726,-0.08065999,0.008344739,0.053365093,0.07408634,-0.06689645,-0.013223878,0.07393985,0.018648943,0.12039697,-0.055857953,0.016130539,0.022704968,-0.008128548,0.0052064657,-0.004355768,0.039765522,-0.011489216,-0.092140384,-0.024617633,-0.018081328,-0.08322067,-0.0020062367,0.089546435,-0.037115563,-0.08219224,-0.101860724,-0.04461381,-0.033934478,-0.02368148,-0.024864588,0.03152151,-0.045056783,0.04295484,0.14013062,0.034123607,-0.10757077,0.082718186,-0.022312796,-0.007177347,-0.008496187,0.03430311,-0.012391447,-0.07933462,0.016854458,-0.0055477247,-0.008409796,0.026061298,-0.072055355,-0.037862133,0.02308959,-0.08600219,-0.070639506,0.038025193,0.04053489,-4.8601276e-05,0.03218303,-0.039860148,0.02022735,0.029399175,-0.060885284,-0.052002646,0.021112569,0.0031660837,-0.036368273,0.0018595725,-0.01879675,0.04110222,-0.035209227,-0.12876919,-0.009609615,-0.08477595,0.043799244,-0.040163253,0.055367265,0.0059585497,-0.050863214,0.053917024,-0.075101644,0.034787,0.036675934,-0.038006604,0.06721578,0.0065514245,-0.07067692,-0.011018312,0.07199215,0.109038115,0.023662683,0.06817762,0.014189506,0.04846903,-0.040384866,-0.06744168,0.07945752,0.045282993,-0.0016165952,0.04588154,-0.066081055,0.022533527,-0.024799436,-0.0784443,-0.065873764,-0.029094826,0.00021485203,-0.014776418,0.015947156,0.06558727,0.063793756,0.05993479,0.058573786,0.00050429825,0.013118127,-0.029606488,-0.0126669295,0.09828773,-0.053789496,-0.082928255,0.015551918,-0.027049141,-0.04898178,0.023102483,0.04320098,-0.017143825,-0.002663775,-0.018717742,-6.9597347e-34,0.090598226,0.08704056,0.053878307,0.0059727645,-0.026779737,-0.0037849923,-0.0155951185,-0.016658178,-0.027149467,-0.019200644,-0.11551234,-0.012211862,-0.021897754,0.031671796,-0.02532584,0.010630625,0.022020163,0.03456079,0.0100677665,0.04630392,-0.07605913,0.07329677,-0.012216356,0.048836038,0.10926351,-0.022740388,-0.030312521,-0.009777153,-0.031840544,-0.0132427905,0.07153634,-0.082085,-0.074596435,0.07882272,0.11385787,0.022259042,-0.01809937,0.047694925,-0.03369125,-0.0072219027,-0.009380444,0.08920531,-0.024518572,-0.05459435,-0.015211819,0.05733084,-0.044044975,0.012509972,0.04560117,0.01676888,0.009191214,0.022158843,0.103846736,-0.053582173,0.0052647297,0.046801694,0.049240477,0.08054499,0.007270627,0.093928106,-0.07583076,0.100767605,-0.015592451,0.067588404,-0.0013720694,0.00034839095,-0.03278087,0.009873732,0.0079861395,0.045202848,-0.057802062,-0.016243514,0.052661896,-0.017308556,0.064272985,-0.03432239,-0.05621915,-0.040611904,-0.017406022,-0.024341794,-0.0136501435,-0.029863888,0.040285468,-0.043941073,-0.07884135,0.016622376,-0.044304777,0.049451306,0.024016665,0.020217264,0.12742795,0.008952719,-0.0007914635,0.0014509751,-0.030933252,-1.1329574e-33,0.07466477,-0.057896964,0.030468548,-0.08218851,-0.040702455,0.055071987,-0.04324991,-0.027684756,-0.011985582,-0.0089724455,0.08797029,0.0715565,-0.08026534,-0.032404672,-0.028593242,-0.016183186,0.05576887,0.11766357,-0.07012161,-0.010014638,-0.04772503,0.040445365,0.04515869,-0.007674662,-0.031112038,0.03952497,0.004118231,0.054621503,0.021021646,0.019305816,-3.4428573e-05,-0.020633534,0.0055065537,-0.10226111,-0.011839385,-0.012417546,-0.035735294,0.04379728,-0.014522252,0.011524457,-0.012369712,0.028096952,0.024164272,-0.058014933,-0.0056047756,0.024355648,-0.07545028,-0.051965106,-0.06765211,0.027987119,0.0008640181,-0.04530947,-0.028692208,0.043073267,-0.0028325445,-0.032025997,-0.02152329,0.046907734,0.024901398,-0.05428792,-0.060025215,-0.08357875,0.0065856846,0.042409774,0.011691184,0.07793609,-0.02018962,0.056269366,-0.027674235,-0.008912423,0.025019623,-0.02441594,0.017851805,0.039416812,-0.03170939,-7.514478e-05,0.004102301,-0.08015916,-0.023272011,-0.014627343,-0.0058763786,0.019114256,-0.017688865,-0.046746727,0.0007494581,-0.059496652,0.024901342,0.041413978,0.03442302,0.039182242,-0.026844475,-0.0066526937,0.0058610225,0.020680903,0.1516109,-2.5976803e-08,-0.018169453,-0.055865005,0.04092426,-0.005637907,-0.03130026,0.031146625,0.052905757,0.11567847,0.13271733,0.005572481,0.034191225,0.07381015,0.020378407,-0.0053912075,0.044000104,0.014147453,0.012149303,-0.017393135,-0.012620965,0.09808641,-0.089255944,0.0016944422,-0.09491767,-0.027892113,0.005021508,-0.06210714,-0.014476994,0.055502877,0.036145177,-0.03145914,0.01622322,-0.00343635,-0.0039838376,-0.049895715,-0.11800575,-0.045321953,-0.042403728,-0.073319755,0.0085530225,0.0976452,-0.013180208,-0.024694718,-0.10226992,0.04501517,-0.029771686,0.0308753,-0.01236876,0.08528548,-0.0025343592,0.053208478,-0.028264612,-0.022269085,-0.03931146,-0.16417211,-0.07416648,-0.0050763753,0.044688493,0.014556325,-0.042593364,-0.013436404,0.010275325,-0.012658151,0.12438755,-0.065103546 +2.1.1.96,"Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers.",384,0.99999994,-0.023802707,-0.051839504,-0.012238071,-0.0073381388,0.029962352,-0.01986491,0.010354221,0.079239964,0.08082269,-0.008680801,0.022266516,-0.032024954,-0.04123637,0.027539099,0.02952254,0.025752204,-0.0083973585,0.0616232,-0.053846665,-0.027584298,0.0593486,0.08219364,0.017894015,0.02506186,-0.057150397,0.052567005,0.032558944,0.024375703,0.039691515,-0.07905824,0.0019000923,0.012379695,0.0037614647,-0.011031321,-0.01699346,0.073580734,-0.0746379,0.033673048,-0.005629195,-0.03095526,0.0861017,-0.07324381,-0.025969455,-0.042879477,-0.0697121,-0.039914284,-0.017063612,0.04856064,-0.015061229,0.037385426,0.0019518422,-0.0057953093,-0.032113038,0.1136571,-0.03408109,-0.05234356,-0.06396204,0.058003254,-0.03524323,-0.022786051,0.030890735,-0.004792864,-0.0034675836,-0.0046597696,-0.044627815,0.04323754,0.053820778,-0.035795357,0.024817081,-0.04906552,-0.00638604,-0.038207613,0.029341316,0.02431414,0.00083212875,0.019883268,0.021541463,-0.06910531,0.035415817,-0.05556744,-0.05985551,0.065655135,0.048306394,0.09210645,0.04680139,0.032396127,-0.042959277,0.027717376,-0.008303455,-0.008171594,0.05621413,-0.019057278,-0.056599338,-0.0652708,-0.02939393,0.045130264,-0.014565544,-0.004202463,-0.0010045685,0.012293069,-0.002254277,-0.011507251,-0.1221947,-0.041714717,-0.05475996,0.0040971283,0.031300906,-0.011113981,0.0036561259,-0.036592662,0.0071453466,-0.01083801,0.102580376,0.03158726,-0.08773668,0.02729479,0.060482826,0.013094249,-0.014120654,-0.08148838,0.010370996,-0.051142663,0.016548462,0.041547578,-0.042410705,0.041391883,-0.058805306,4.1871494e-33,0.059504256,0.069830805,0.08572449,-0.042846154,0.01754018,-0.01605425,-0.051502276,0.03179117,0.033365183,-0.004800373,-0.029631766,-0.08637102,0.042539965,-0.0048853173,-0.036547147,-0.060973465,-0.015201415,0.045616996,0.06218083,-0.13489102,0.008062274,0.07818851,-0.05009579,0.066419505,-0.0104830535,-0.019056195,0.010427792,0.055591356,0.03344235,-0.011330048,0.056823023,-0.044099323,0.013416138,-0.016187338,0.022899458,0.11040365,-0.124775425,0.05466266,-0.0007462398,-0.00019727455,-0.015294072,-0.008510852,-0.00043136536,-0.015713135,0.01105811,-0.08113735,-0.1164261,0.08626489,0.036281772,0.020647349,0.038656782,-0.08480103,0.07789771,-0.08120596,-0.040986974,0.0029845654,-0.027418265,-0.052543446,0.00813746,0.08509029,-0.02146574,0.014800054,-0.05621502,-0.04228952,-0.0108406115,-0.021102019,-0.051454186,-0.04031929,-0.09908771,0.007810721,-0.05904344,0.04934659,0.062712856,0.036459472,0.026275042,-0.0003229696,-0.025574937,-0.073191,0.062076993,0.03517813,0.009855855,-0.067003064,0.02862015,-0.02240412,-0.067404486,-0.0702075,-0.015056019,-0.055166177,0.027184347,-0.016203312,0.04708116,-0.0859634,-0.06540436,-0.01699213,-0.0440213,-4.4828315e-33,-0.04067305,-0.025367381,0.04109035,0.025979673,0.019913793,0.014038867,-0.022617258,0.033238,0.05505302,-0.039928574,0.13844717,0.006146499,-0.04724547,-0.05001853,-0.015289647,0.099210195,0.033312295,0.061871435,-0.011879101,-0.011803716,-0.027897397,0.07052824,-0.035010032,0.07639856,0.050307658,0.037929375,0.014568376,-0.015071757,0.050791398,0.12424252,0.04630918,-0.016775088,-0.056845963,-0.046775725,-0.029129202,-0.032703377,0.025376257,-0.03185882,-0.05282521,-0.060136963,-0.015825327,-0.048390746,0.13035473,0.123737894,0.023587413,0.01927924,-0.07038296,-0.015524814,-0.039885454,-0.04376757,0.031070769,0.019332398,-0.0017962832,0.06746705,0.080207795,0.079030015,-0.032423615,-0.04245099,-0.049923345,-0.060011454,0.002395466,-0.019059658,0.006322325,-0.040350076,0.009977324,-0.038206194,-0.08551822,0.041384522,0.048614603,-0.038109668,0.06662742,-0.005913972,-0.031837855,-0.08230467,-0.07586379,-0.093932755,-0.008004816,-0.063377656,-0.046197604,0.06004684,0.060542632,-0.012000317,-0.028523194,-0.06673709,-0.018407797,0.004442869,0.035165567,0.143115,-0.03101641,0.066711694,-0.09513636,0.0445726,0.007673045,0.12446315,0.06935193,-3.372811e-08,-0.010363923,-0.063689806,0.029382546,-0.055499636,-0.082211405,0.019141901,0.11336696,0.07898249,-0.007614104,-0.0032363324,-0.04045868,0.11301282,0.010189334,-0.050760962,0.112929456,-0.041832678,-0.019047495,0.047503494,-0.03917377,-0.12184231,-0.02596502,-0.035723805,-0.022863282,-0.0068471194,0.06298792,-0.04052232,0.04686153,-0.04281471,0.024323933,0.0070462157,0.05810773,-0.01468659,-0.015916634,-0.067665435,-0.008742709,0.077624686,-0.042740718,-0.014602538,0.013715741,0.053429674,-0.01997188,0.006081427,-0.0783347,0.079782605,0.026965147,-0.036969848,-0.001289898,0.08965942,-0.04941857,-0.029724546,0.0077506043,-0.0053913128,-0.0051167677,-0.033791684,-0.10536126,0.049611595,0.04290631,0.004554706,0.05332632,-0.051961545,0.03981651,0.017078752,0.1453557,0.024136461 +2.1.1.97,Involved in the biosynthesis of the antibiotic actinomycin in Streptomyces antibioticus.,384,1.0,-0.027812736,-0.048641607,-0.11783024,0.023449082,-0.04298612,0.028716447,-0.0067554205,0.06860154,0.05100535,-0.0012439942,-0.023254123,0.010407083,0.107287884,0.04008623,-0.04177058,0.00020328234,-0.047832765,0.0029462867,0.04699035,-0.002082331,0.11365486,0.08233733,-0.002649931,-0.01750327,0.055605702,-0.051578045,-0.0580928,0.029575603,-0.05318467,-0.05589348,0.05729841,-0.0107104555,0.098953545,-0.08773019,0.13506311,0.054621864,-0.05604263,0.0022880954,0.18260461,-0.021520926,-0.04961445,-0.012657957,0.022817949,0.056802202,-0.041591447,0.0749519,0.03015454,0.076311626,0.031822983,0.011298084,-0.072892256,-0.018679945,-0.04803191,0.055976506,0.07819078,0.059393506,-0.003911295,0.009540991,0.007565621,-0.047268514,0.04991449,-0.04984951,0.040508553,-0.010681642,-0.15387818,-0.010987354,0.0438179,-0.0771375,0.074484415,0.0018093572,-0.058869295,-0.009763885,0.008651148,0.008253062,0.014356727,-0.02013633,0.021207467,-0.027527172,-0.08851151,-0.0020126372,0.025919477,-0.022873478,0.015372136,0.062158704,0.050920963,-0.03265933,0.06035035,-0.005022135,0.045026984,0.060698394,0.03436125,-0.038948093,-0.010435922,-0.067691244,-0.019679986,-0.03641856,-0.07475617,0.022177346,0.032804087,-0.043493863,-0.003412192,-0.0045550545,0.016497856,0.006109454,0.06680893,-0.03128286,-0.010906215,0.053772595,-0.014266456,-0.020421105,-0.0018587338,0.0009917028,-0.031325966,-0.033736542,-0.03744356,0.004146394,0.13248828,-0.050767448,-0.106769376,-0.023198493,0.03617567,0.08510966,0.012652503,0.012990297,-0.018997833,-0.029324815,-0.06824803,-2.4268397e-35,-0.07337284,0.035904426,-0.01211287,-0.056997392,0.03879993,-0.027160436,-0.06889366,-0.05967041,0.07570874,-0.013626352,-0.079606324,-0.111174814,0.019239662,0.05395098,-0.0026119978,-0.015174939,0.003649397,-0.0044998485,0.044888318,0.027839432,0.0028865722,0.030186502,-0.04238284,-0.022287264,-0.005260709,0.036962524,-0.01704348,0.04237727,0.073166735,-0.049704235,0.0018043646,-0.0431623,-0.045773033,0.0052829827,0.0826277,-0.0595109,-0.044191778,-0.037623703,0.117084704,-0.0022288242,-0.06722773,0.041732717,-0.014159647,0.00060168374,0.07014763,0.03951971,-0.04903505,0.042066503,0.07861375,0.056360703,0.06228636,-0.06047834,0.10985746,-0.008349732,-0.03658904,-0.0034266873,0.0013534708,0.055002287,0.039529245,0.06152304,-0.011340253,-0.023930985,0.06727686,0.018317662,0.035727005,-0.025476366,-0.011846149,0.005759937,-0.01167443,-0.02372511,-0.040073656,0.012656624,0.013101941,-0.038552567,-0.014692894,0.015489008,-0.06947477,-0.042036965,0.05176404,0.018905701,-0.035996933,0.023706188,-0.06892261,-0.054273345,-0.027944602,0.060048055,-0.033217736,-0.08805804,0.05357019,0.05867284,-0.05886192,-0.11564125,-0.12167778,0.04297729,0.016906291,-2.9361026e-33,0.07289218,-0.015470861,0.08513279,-0.0071519343,-0.070618466,0.06880731,-0.050564904,0.008643869,-0.016490769,0.0115694655,-0.01997147,-0.0050477097,-0.107460275,-0.047379106,-0.004185604,-0.037904363,0.030990576,0.09377825,-0.008904499,0.036336344,0.034459937,0.07582796,-0.03616902,-0.026924774,-0.0037709293,-0.005336417,-0.021854924,0.041759927,0.044139013,0.0709271,0.023725966,-0.051810663,-0.08935629,-0.0633191,-0.022895776,0.06572227,-0.03968586,0.08178894,0.045617584,-0.07636251,0.09994048,0.023681918,0.021202248,0.06851001,-0.011068582,0.026260072,-0.054740563,0.0306625,-0.02792943,-0.09938008,-0.027186016,0.0009637222,0.050095793,-0.039753616,0.00221223,-0.038849078,0.025235772,-0.012992305,-0.019675853,-0.011412979,-0.016309954,-0.024855725,0.013110182,-0.04004551,0.017489012,0.062550545,-0.029831178,0.0043764124,0.0956959,0.013968165,0.012386579,0.016407996,-0.0736017,0.035126198,-0.00020234851,0.018508844,-0.06936082,-0.060498644,0.020720007,0.061555736,0.023860728,0.0036612975,-0.0025633122,-0.0027487774,-0.06621226,-0.02774851,0.044818837,-0.008194194,-0.023628313,0.012626312,0.025287671,0.054257218,0.035379257,0.008268967,-0.043207224,-2.2492543e-08,0.07661898,0.023102498,0.104630165,-0.04303553,-0.013954972,-0.07503896,-0.07673795,-0.032772567,0.015613995,-0.009343563,-0.03331482,-0.029240686,0.015104663,-0.05221482,-0.027751155,0.000113886636,-0.101272404,-0.005906536,0.028175257,0.03560088,-0.056132413,-0.022340616,-0.107070796,0.02503899,0.068905585,-0.043980125,-0.00095513416,-0.05831861,-0.026017552,0.058544885,0.10971068,-0.0042884415,-0.061567567,-0.0065491567,-0.05167657,-0.10920041,-0.08200574,-0.07325825,0.06786214,-0.048165716,0.017960906,-0.009011681,-0.0026379824,0.05102985,-0.10083399,0.051886767,-0.08707765,-0.04864177,-0.010802177,-0.0096657155,0.10569069,0.042571712,-0.030553117,0.026284706,-0.09542319,0.036917392,0.047214575,-0.012672723,-0.036227632,-0.009065091,-0.05293487,-0.028702365,0.11512809,-0.03261519 +2.1.1.98,"This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14, diphthine---ammonia ligase. Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314). In the archaeon Pyrococcus horikoshii the enzyme acts on His600 of elongation factor 2.",384,1.0,-0.020923384,-0.008623008,-0.05117737,-0.09474042,0.04305725,-0.0042640874,-0.07070479,0.026695898,0.0014561174,-0.025132984,0.025780223,-0.10807014,-0.10907959,0.0050322344,-0.050190758,0.036081173,-0.09095255,-0.05429302,0.02288912,-0.04788026,0.042145636,0.070816435,-0.01364037,0.029695168,0.024494193,0.013923617,0.048260517,-0.011735553,0.034747683,-0.053486194,-0.006320584,-0.05003981,0.015217978,-0.092803724,0.08524868,0.071154416,-0.05478629,-0.023056036,0.07707707,0.054761074,0.1335212,-0.041122492,-0.00031402538,-0.090387955,-0.033393655,0.090204455,0.08110242,0.037011176,0.04283963,0.007581379,-0.07582619,-0.044407323,5.309326e-05,0.013549204,0.056733523,-0.0043862835,-0.06951509,-0.031760316,-0.040046144,-0.033084318,-0.013538749,0.013540247,-0.005908344,-0.049570724,-0.013257535,-0.0591485,0.056866564,-0.08463158,0.020447265,-0.046841934,-0.11065179,-0.058175955,-0.0029830008,0.052923586,-0.008749071,0.04295639,-0.0036622938,-0.07834206,0.051169515,0.0003529515,0.01962329,-0.035748743,-0.05741779,0.0010368824,-0.046846792,-0.029209588,0.041649267,-0.014869847,0.040657185,-0.014676253,0.013468251,-0.06813265,0.001389258,-0.09056035,-0.07997114,0.045975503,0.0349092,0.071521856,0.04755193,-0.009248834,-0.04832958,0.0070423675,-0.07397598,-0.11061982,-0.09846701,-0.0044633183,0.008121531,0.11754105,0.06991083,0.07205326,-0.035711233,0.030102273,0.031347338,-0.038023546,-0.03917353,0.021649094,0.022336353,-0.09868376,-0.06234559,0.06543187,0.01816814,0.008772832,0.09088652,0.16005906,-0.0207039,0.030941494,-0.11371277,1.7762263e-33,0.054153692,0.023124648,0.042099807,-0.04294783,-0.03161605,-0.004190595,-0.1014842,0.00070594787,0.010839031,-0.09258648,-0.077516764,-0.064877465,0.079092056,0.032538023,-0.029862981,-0.03743713,0.0065484783,0.017587287,0.03595735,0.010646262,-0.025561303,0.085015744,-0.042028256,0.055402193,-0.0043132035,-0.029747078,0.03813909,0.006467754,-0.007281311,-0.0021099723,0.02511731,-0.088084705,-0.106454805,-0.030688837,0.06083034,-0.027867967,0.010094488,-0.0788183,-0.03598101,0.005019655,0.0027018928,0.04380949,0.026948262,-0.027785415,0.013583816,-0.07280065,-0.013141216,0.058618054,0.069742955,0.017017864,0.02160909,-0.01605778,0.1148111,0.009400945,-0.023412595,-0.043802697,0.012016097,-0.036905393,0.07559678,0.06757624,-0.050610464,0.08522178,-0.05396533,0.020465268,-0.019423716,-0.002884523,0.0018498002,-0.013523314,-0.0006653351,0.057523027,-0.035353538,-0.011927307,0.009131091,0.06275908,-0.01949267,-0.04253875,-0.1049286,0.010316783,0.036781114,-0.022760466,0.0015969436,-0.016763827,0.034472458,-0.023751128,-0.0037151726,-0.017205592,-0.026650302,-0.001299708,0.046465285,0.08813627,-0.00013606471,-0.10031415,-0.020115962,0.04788389,0.028205434,-2.6860669e-33,0.029630559,-0.09349713,-0.013229449,-0.07478236,-0.060209606,0.056120645,0.06665061,0.06724458,-0.045460176,-0.040477894,0.10198576,-0.0033875722,0.057172302,-0.020351388,-0.0016932137,-0.04119476,0.029994693,0.06877104,0.06880403,0.009886369,0.08096015,-0.0024127031,-0.0069012824,0.0107857585,0.00053066737,0.023427887,0.044442438,0.11679264,0.024920149,0.043016,-0.06837124,-0.01105375,-0.001708589,-0.00783946,-0.03715229,0.0061840853,-0.00059506553,-0.013154306,0.023904461,-0.046386488,0.009145855,0.01804911,-0.004516079,0.037679836,-0.012890935,0.06691191,-0.03320492,0.02313716,0.041939616,-0.05597658,0.035991527,0.048228495,0.10364114,-0.015724521,-0.009106568,-0.05489873,0.0053624287,0.006712139,0.043487746,0.0073272004,-0.026084984,-0.0946353,0.02819498,-0.06475238,0.038162645,0.0668132,0.0030207387,0.014040401,-0.018566156,0.0052658296,0.049869895,-0.0021378375,0.078982964,0.027787808,-0.0169291,-0.021672707,0.03736059,0.012428621,0.085571,-0.06660662,0.032262284,-0.039132107,0.012432752,-0.06784991,0.014270589,-0.024047924,0.06889589,0.04292188,-0.053899497,0.008265147,-0.013870835,0.0049264836,-0.041593794,0.061083075,0.11802239,-3.8921957e-08,0.013245492,-0.079363726,0.04536581,-0.00707041,-0.011962011,0.07730006,0.0045641894,-0.0070048426,0.02300769,-0.061858583,0.063356064,0.06844672,0.034011487,-0.007047375,0.08658062,-0.030546581,-0.032511894,0.050277285,-0.0058501805,-0.022867242,-0.048887897,-0.015858388,-0.05204778,-0.008530155,0.0024313885,-0.029739605,0.04033783,0.043994408,-0.009027588,-0.08070459,-0.016646273,0.04221828,0.0032517428,-0.013852154,-0.083821245,0.04353091,-0.08961102,0.017687993,-0.012889871,0.03964206,-0.006081997,-0.0017051796,-0.1157316,-0.029097628,0.03957049,0.03881763,-0.005096138,0.026171122,-0.033069085,-0.040296253,0.07994489,0.010567886,0.10836142,-0.04703673,-0.10934336,-0.04636895,-0.042499922,-0.08458054,-0.04554764,-0.010260768,0.13216044,0.02762887,0.14011054,0.029198596 +2.1.1.99,Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle Catharanthus roseus.,384,1.0,-0.055180706,0.013012914,-0.1268509,-0.06588005,-0.050056726,0.06897748,-0.09264903,0.036454417,0.028442845,0.016382437,-0.004811254,-0.021968909,-0.0060206004,-0.05898612,-0.07628096,0.065544724,-0.06994784,0.06312378,-0.022615364,0.018700995,0.03378733,0.061077565,-0.008981024,-0.011908051,0.021568006,0.02716463,-0.018310132,-0.00059906865,-0.056052294,-0.05574085,-0.00050743175,0.0057657985,-0.04641833,-0.09156834,0.009118434,0.034072,-0.023862679,0.0010222001,0.12032613,0.09156226,0.020648379,-0.01037273,-0.08244474,-0.023861695,-0.0018754823,0.008587343,-0.014762262,0.022168709,0.08144105,-0.06751293,-0.08768817,0.0109442305,-0.07241243,-0.05520453,-0.055203386,-0.0761732,0.044673175,-0.0022448697,-0.028187182,-0.02081916,-0.012209788,-0.00016967434,0.051451553,0.004617111,-0.036273412,-0.050571706,0.0042713173,0.01745482,0.05843353,-0.09208572,-0.009433924,-0.04175509,0.011385628,-0.03767989,-0.10594132,0.052008417,0.006026839,0.057437446,-0.0043052044,-0.023471164,-0.047999952,-0.00033944973,-0.008065711,0.086305566,0.05458675,0.049916435,0.060147207,0.03563224,0.036293402,0.09437538,0.030095328,-0.012046977,0.05190649,0.009444125,-0.056656867,-0.004816191,0.047516756,-0.04230305,-0.0023883113,-0.047173716,0.030356802,-0.0309859,-0.018792922,-0.030969968,-0.059629124,0.04701742,-0.0074917576,0.06474332,0.03146996,-0.044347122,0.007256467,-0.0019094977,-0.013529464,-0.007569149,0.013819328,0.08094872,0.05175806,-0.024614856,-0.013762558,-0.024369735,-0.0109530585,-0.01344783,0.018903634,0.01814594,-0.021706905,-0.023726078,-0.05109191,8.08785e-34,0.05493907,0.063637726,-0.0044148196,-0.07037022,0.06398096,-0.0015855898,-0.17714562,0.029706871,-0.034305144,-0.024548333,-0.0985366,-0.12051935,-0.010672248,-0.022205211,-0.050731447,0.04855229,-0.0175226,-0.042709213,-0.013680093,-0.0049719894,-0.02462488,0.016714497,0.026226375,0.0102767255,-0.02137531,0.041697565,-0.012450202,-0.052383494,-0.066479124,0.011179906,0.038140908,-0.20710756,-0.006715175,0.021306777,-0.010658921,-0.012953039,-0.02023927,-0.083529264,0.019209826,0.057180062,0.00717564,0.017565714,0.030739425,0.011736603,0.031985123,-0.039079446,0.02758792,0.1732557,0.025973799,0.028376937,-0.04273711,0.024617981,0.18750694,0.026815506,-0.11292659,0.016851727,-0.0176992,0.017890707,0.04500183,0.05253133,0.043964375,0.044221994,0.028603435,0.014164173,0.025156034,-0.010243291,-0.033678252,0.020579014,0.0773224,-0.021303944,-0.047544345,-0.008386734,-0.00628349,-0.03772587,0.08065137,-0.061923955,-0.011673305,-0.023702862,0.039053075,0.022986861,-0.015666688,0.028911363,-0.048419997,-0.013970075,-0.012423246,0.06395368,0.052861024,0.013354559,-0.026643008,0.08636036,0.039815027,-0.03269232,-0.030124439,-0.029837828,0.084941156,-1.6178163e-33,0.017082296,-0.031832214,0.014082433,-0.03621491,-0.022411635,0.056286506,-0.082242146,0.049864333,-0.028678523,-0.05249102,-0.050198946,0.016170891,0.059196424,-0.03257441,-0.043314908,0.0005870361,0.02692338,0.10168577,0.041918848,-0.084306635,-0.011822064,0.029302688,0.0065771467,-0.00389483,0.024682805,-0.023890665,-0.0005518802,-0.016582426,0.010989021,0.0759171,0.06153014,0.06016827,-0.08837215,-0.044379767,0.012362507,0.083450764,-0.03424548,0.078575134,0.06498367,0.07192529,0.019536829,-0.012946783,-0.032991055,0.019595584,0.012340097,0.020759163,-0.04142711,0.055058077,-0.04327942,-0.0073945387,0.0837197,0.02113606,0.074263245,0.027443547,0.053023335,-0.000113879825,0.01893761,0.028321292,-0.023488712,-0.048159715,-0.05225326,-0.060637783,-0.0107130585,-0.013434623,0.01044635,0.060575455,0.01700805,0.026959231,0.09848481,-0.05397346,0.06132715,-0.01338517,-0.0105292825,0.06739369,0.026345564,0.03591418,-0.05768715,-0.06592342,0.008295638,-0.00121156,-0.015810698,0.0031986076,0.036910806,-0.11016855,-0.08629814,0.03248958,0.02864633,0.061143517,-0.040150948,0.019186214,0.017371425,0.021543182,-0.091540866,0.02495672,0.0424104,-2.4723246e-08,0.09561024,-0.02846319,0.07776311,0.0305911,0.00075873936,-0.008374142,0.041954577,0.040440794,0.010215974,-0.0019130856,0.030760296,0.057292946,0.04731992,0.0135199325,0.06274362,0.058612276,0.102414586,0.017939193,-0.010573675,0.028897267,-0.06764449,0.022037325,-0.044848856,-0.029344684,-0.007045315,-0.1000242,0.0037330615,-0.036102626,0.010088938,-0.049838092,0.0644261,0.0018778075,-0.021707306,-0.15901323,-0.06944735,0.0047538215,-0.031330094,-0.07051864,0.06440648,-0.05321658,-0.011577269,-0.041133303,0.018042643,-0.0013639005,-0.03307997,-0.0075613917,0.023064688,0.045860313,-0.035766985,-0.081162035,0.016192457,0.028138269,0.07829173,-0.10538066,-0.14538276,0.04861772,0.055904783,-0.054206178,0.03378654,-0.056095105,-0.029394874,0.042922504,0.11705522,-0.09750466 +2.1.1.100,"C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.",384,1.0,0.053436846,-0.017271487,-0.08485212,-0.015148246,0.10282751,0.07295901,-0.06295562,0.03917262,0.06291312,-0.049039654,0.09936466,0.014401765,0.046665285,0.051180463,0.009212356,0.010644737,-0.04277845,0.020082207,-0.02855559,0.023856265,-0.067509994,0.0025730736,-0.038711272,0.025791094,0.024831647,-0.03101935,0.0075398213,-0.015925145,-0.010787893,0.02424582,-0.098715805,0.016427564,-0.017805241,0.04302164,0.023333522,0.047961917,-0.0027113047,0.024045613,0.06418276,0.009071221,0.019350447,0.012508347,0.009950651,0.01352851,-0.07917675,0.012181059,-0.0010277954,-0.032842234,-0.10047249,-0.020540765,-0.016361676,-0.0529813,-0.014059428,-0.012320016,0.034025922,0.005513049,-0.013787499,-0.03821931,0.018151518,0.029503053,0.0070073707,-0.051569086,-0.04995236,-0.052696887,0.03478144,-0.01593409,0.14296748,-0.07019096,0.031759553,-0.045612462,-0.022192867,-0.03439292,-0.09598823,0.0646275,-0.04356325,-0.016317617,-0.008783805,0.0089518875,0.042483367,-0.07963927,0.005963727,0.007930986,0.019380856,-0.027508697,0.038391367,0.024362857,-0.09224315,0.11458705,0.003876415,0.024687009,0.03378351,-0.0005007242,-0.0053283996,-0.09785997,-0.09766992,0.00117644,0.073393345,-0.0024639692,-0.012445216,0.0058693807,0.03426767,0.034091502,-0.024416728,0.008938851,0.022346463,0.012413927,0.024255006,0.08272636,-0.14102788,0.0202646,0.00075129996,0.028682249,0.08566389,-0.055222597,-0.06478273,0.0547715,0.08616505,0.056800555,-0.020120438,0.054354772,-0.008371487,0.040312454,0.021918707,-0.0045284424,0.0052524093,-0.05652726,0.0008020826,2.4899762e-33,0.07382905,0.006297081,0.044177737,0.02219785,-0.019521575,0.05402793,-0.013051477,0.064887546,0.026499096,-0.077798754,-0.082797244,-0.115962416,0.0004551233,-0.013372181,-0.06946965,-0.04040276,-0.019734047,-0.052909184,0.0110688675,-0.09569832,-0.025387876,0.07779574,0.032421015,-0.072985224,0.031176168,-0.060688138,0.024984173,-0.008893096,0.044299085,0.017084522,-0.030122625,-0.022996077,-0.06386762,-0.019912973,0.045921326,0.044085033,-0.034232553,-0.017184848,0.039711606,0.021526998,0.0348935,0.04042112,-0.03847973,-0.036743946,-0.067098804,0.018499117,-0.046057835,0.08130851,-0.064799964,0.036371417,0.018291015,-0.016948972,-0.08283877,-0.0025866416,-0.07799352,-0.020844871,0.05598855,-0.019865755,-0.055308107,0.05630227,0.007773043,0.03664714,-0.03697574,-0.027728735,0.058672953,-0.02349062,-0.13682295,-0.033456642,-0.004181342,0.030809492,0.044195328,-0.06170249,0.17881472,0.05690821,0.017081304,-0.0157907,-0.120816864,-0.014515892,0.06442255,0.021378092,-0.0765797,0.01626119,-0.06279315,-0.01874877,-0.048131883,-0.015162389,0.03655263,-0.053780727,-0.066284396,-0.0466236,-0.02564397,-0.030238789,0.04410397,0.032490812,0.009369451,-4.5181224e-33,0.036061272,-0.04029541,0.04940905,-0.033040065,0.036738366,0.007999308,0.012199579,-0.028885406,-0.10860994,-0.0744373,0.11595058,0.010203044,-0.075079076,0.05185707,0.040471602,0.0006987266,0.007758741,0.101568714,0.058588773,-0.00015733228,-0.034486912,-0.04688928,-0.030179752,0.0671725,0.051750135,0.008163639,-0.016299585,0.048581593,0.03109044,0.1430887,-0.039583534,0.015654385,-0.040790293,-0.07077148,-0.017575318,0.06268601,-0.06299177,-0.010662406,-0.042591672,0.038485672,-0.016047876,-0.009333742,0.0050079892,0.11327905,0.04968426,0.052703403,-0.053434487,0.016864436,0.03926016,-0.042035256,-0.033048652,0.0011882848,-0.039170604,0.031088019,0.008625309,0.048494685,-0.013870788,-0.036420517,-0.00452095,-0.07970238,-0.102910906,0.039487995,-0.037099313,-0.04832252,0.06198568,0.031018006,0.01632768,-0.039614517,0.09600974,-0.083377026,0.05296385,-0.011639906,0.030480523,0.033817787,-0.06706443,-0.121348366,-0.019984916,-0.0067569595,-0.04525529,-0.045988593,0.049343966,0.0029019304,-0.015550907,-0.010571281,-0.06503742,-0.048717592,0.031104766,-0.0028625485,-0.02404712,-0.018347066,-0.025438229,0.104204156,0.014449773,0.100823425,0.10458455,-3.079149e-08,0.07175963,-0.10938455,-0.010838799,-0.046343245,-0.0073247314,0.077259205,-0.057890277,0.06559202,0.0442327,-0.0062526627,0.066464595,0.05547833,-0.044539098,0.03893076,0.0049068755,0.045385446,-0.057480372,-0.004629261,-0.0068881037,-0.00844476,-0.08108916,0.010500105,0.00088861457,-0.0623311,-0.07891215,-0.00409706,-0.0057917894,0.09850691,-0.017247818,-0.04408891,0.10030976,-0.0046512946,0.02505368,0.06437885,0.02237604,0.008542285,-0.012613973,-0.063530736,0.006213118,0.009012499,0.0032856797,-0.0010309084,-0.09694388,0.074174255,0.07469949,-0.08133146,0.010641044,0.12888022,-0.011654938,0.03057927,0.028882047,-0.0015046869,-0.0526703,-0.033898823,-0.027515247,-0.0015930445,-0.033988196,-0.04285777,0.019189492,-0.01011206,0.027977278,-0.0078014634,0.12791756,-0.019663054 +2.1.1.101,"Requires Mg2+, Mn2+ or Co2+. The 3-hydroxy group of the 2-O-methyl-6-deoxy-D-allose moiety in the macrolide antibiotic macrosin acts as methyl acceptor, generating tylosin, another macrolide antibiotic. Isolated from the bacterium Streptomyces fradiae. Not identical with EC 2.1.1.102, demethylmacrocin O-methyltransferase.",384,0.99999994,-0.03738459,-0.0024885023,-0.08055389,-0.012264836,0.035824493,0.0012878857,-0.046953894,0.08664628,0.07165939,0.032388743,0.03857829,-0.03478012,0.03507691,0.04394613,-0.004328862,0.0018056413,-0.044051487,0.04675821,-0.01455455,0.059959386,0.059252292,0.1010467,0.04028479,-0.0053190775,0.0070106443,0.0132622775,0.016896114,0.0142801255,0.015511977,-0.06877246,0.009939662,-0.009480781,0.07073972,-0.064683825,0.12223699,0.023407277,0.009243265,0.014416428,0.0769888,-0.009912753,-0.04652302,0.0047819894,0.07762805,-0.00029035655,0.007699118,-0.029652389,0.07754514,0.018047545,0.11138839,8.1674916e-05,-0.03923336,-0.039113495,-0.043545883,0.096312135,0.047508612,0.024032623,-0.09557879,-0.05149393,0.04460865,-0.050007503,0.04441439,-0.0601011,0.017163698,-0.006756447,-0.088638216,-0.015858471,0.043840215,-0.044609185,0.009008518,0.008406552,-0.037447512,-0.046427567,0.038223453,0.059814896,-0.024769265,0.046138752,0.0070854113,-0.07200616,0.017830297,-0.0092294905,0.014495201,-0.04169541,0.020194763,0.09120402,0.030446954,-0.049771275,0.02287973,0.056642063,0.07798238,0.087897114,0.0031339254,0.027900558,0.02844967,-0.08723625,-0.007889711,-0.024869908,-0.063399345,0.057546202,0.081315175,0.009255556,-0.041474227,0.07341389,-0.0045731706,0.0020641827,0.032182157,0.026343618,0.019925645,0.059266586,0.08613161,-0.03161257,0.019921903,-0.016010892,0.017583627,-0.03179651,-0.04317403,0.0085428925,0.11256777,-0.08989078,-0.01893096,-0.070751496,0.07230372,0.004958457,0.034788154,-0.005466089,0.007173017,0.012611641,-0.0561273,3.0832137e-33,-0.014742981,0.054497056,-0.008324936,0.008462665,0.022676963,-0.026717834,-0.09409292,-0.038267456,-0.039623305,-0.03353605,-0.17347917,-0.10025928,0.020518146,0.14367002,-0.02358118,0.0017214874,0.027731895,0.015835373,0.0115247965,-0.038407616,0.035530373,0.06820736,-0.048955843,-0.0069738296,0.02151723,0.12743893,0.050942644,0.042917594,0.1070127,-0.040862318,0.06835974,-0.07425678,-0.028897334,0.044528395,0.084400125,0.004685844,-0.07702255,0.001241044,0.07243067,0.021667767,-0.06460008,0.027622608,-0.1152307,-0.024663454,0.068693176,-0.050876122,-0.009171581,0.0010795201,0.0722998,0.024933284,0.088796884,-0.053500716,-0.058838587,-0.0015016973,-0.038368247,-0.017205082,-0.033822764,0.10097295,0.073327586,0.061329275,-0.004266866,-0.006239346,0.015270632,0.04609947,0.06294243,-0.024430119,-0.046507683,-0.0012736242,-0.043805614,-0.010655895,-0.010835313,-0.024730692,0.021403024,0.022938507,-0.013926995,0.021554716,-0.060101315,-0.024023158,0.10753541,0.0077891285,-0.05133097,-0.04553722,-0.017843615,-0.016887646,-0.10395994,0.11702893,-0.032601986,-0.0682694,0.017313039,0.042638,-0.059258826,-0.107175045,-0.08627887,0.020138832,-0.034891192,-4.3911227e-33,0.04385062,0.046819743,0.05643715,-0.09541393,-0.0927688,0.09436024,-0.01855476,-0.06576409,-0.003502946,-0.040685404,0.077979624,0.00316992,-0.027622433,-0.05946614,0.0052227876,-0.053171493,0.031627096,0.022787476,-0.06858457,-0.011450252,-0.008395155,0.033548944,-0.017800279,0.0010055912,0.049215388,0.06968352,0.02413325,0.05324,0.050846692,0.09620569,-0.02181657,0.0034988476,-0.00469758,-0.060731065,-0.0022793536,0.1466222,-0.08530155,-0.022664247,0.011943145,-0.021973258,0.021783797,-0.029529797,-0.03765444,0.061586212,-0.011934587,0.050882384,-0.042030614,0.004054135,0.04739753,-0.036897324,0.0051406715,0.03321122,0.032132566,-0.039980404,0.018629074,-0.027297033,0.040889774,-0.047372356,-0.012592365,-0.0564109,-0.00064668077,-0.036467075,0.07817601,-0.065374486,0.04292789,0.093286715,-0.0076093185,0.05225186,0.013706682,-0.03037177,0.0062268614,0.0173648,0.009562746,-0.0139353145,0.0043521747,0.02374005,-0.042822044,-0.03426056,-0.008930411,0.021500528,-0.027112715,-0.008473025,-0.0039011675,-0.008445651,-0.07671872,-0.045096096,-0.025926897,-0.0066788904,-0.008155652,0.018452099,-0.06323878,0.015941212,-0.014224796,0.06371891,-0.0312799,-4.4022944e-08,0.0450465,-0.042316597,0.024527192,-0.09649636,-0.024113104,-0.004079149,-0.11243516,-0.034681275,-0.011018172,-0.0124451285,0.0076444233,0.043027937,-0.013018115,-0.04077597,-0.022182543,-0.025734298,-0.0860081,-0.027114367,-0.031173656,-0.04777812,-0.07573245,-0.007333131,-0.0556871,0.016108962,0.063441075,-0.05767554,-0.011115713,-0.0037367519,-0.012403905,-0.0010407619,0.07956388,0.039495837,-0.07511233,0.009244706,-0.046145473,0.0027809,-0.07826055,-0.02569248,-0.0055287466,-0.0015631779,0.036618307,-0.00396807,-0.06456163,0.028886769,-0.09905195,0.01764137,-0.070977874,0.003893632,-0.09794148,0.016581975,0.08520252,-0.0018275864,-0.0048374506,0.034855314,-0.15058033,0.006788651,0.014092949,-0.037480477,-0.042730357,-0.03414334,-0.025869785,-0.105937906,0.14020884,-0.042104077 +2.1.1.102,"Requires Mg2+. The enzyme, isolated from the bacterium Streptomyces fradiae, is involved in the biosynthesis of the macrolide antibiotic tylosin. The 2-hydroxy group of a 6-deoxy-D-allose moiety in demethylmacrocin acts as the methyl acceptor. Also acts on demethyllactenocin, giving lactenocin. Not identical with EC 2.1.1.101 macrocin O-methyltransferase.",384,1.0,-0.045933533,-0.024525795,-0.070130594,-0.006463166,0.057541776,-0.034466926,-0.0540611,0.09098015,0.06495253,0.0043539554,0.027942182,-0.029283436,0.028383883,0.041231822,-0.028539471,0.0027255865,-0.05901907,0.058862373,-0.002574361,0.0090672625,0.09570896,0.067116596,0.05356372,0.015445466,0.05058646,-0.014806417,0.024325842,0.06146812,-0.010288337,-0.0608273,0.013322372,-0.0028326807,0.044995215,-0.06609535,0.089631855,0.0635236,0.023935562,-0.024876367,0.074211046,-0.042819463,-0.0028770992,-0.03466806,0.04453362,0.013816087,0.002060339,-0.04989119,0.092469946,0.004310273,0.06690047,0.021208273,-0.037947565,-0.03207608,-0.032093756,0.066014275,0.07356782,0.028328264,-0.0804966,-0.04996699,0.027385177,-0.030005245,0.029266471,-0.022533432,-0.017085578,0.00785036,-0.0868524,-0.028498812,0.058415573,-0.06644118,0.013123662,-0.030483665,-0.04813519,-0.056202326,0.044383813,0.03009285,-0.018296987,0.032852825,0.00233352,-0.070746675,0.015860071,-0.016918434,0.051863365,-0.050626155,0.009226469,0.094381735,0.017143652,-0.07986374,0.0813594,0.018309921,0.06792192,0.105892874,0.045190495,0.019005708,0.000678148,-0.108600214,-0.0033588726,-0.0327673,-0.04944029,0.043204978,0.054399572,0.01552149,-0.050956454,0.05679238,-0.008996587,0.008346222,0.0061866282,0.011584816,0.0025891615,0.029781833,0.10044172,-0.039342143,0.022150185,-0.03580523,0.006630339,0.01493817,-0.060220975,0.047149774,0.11890199,-0.08257588,-0.041212443,-0.054089904,0.010873731,-0.0061383406,0.041212335,0.02857754,0.009748596,0.015901834,-0.06302712,4.0354056e-33,0.020470314,0.053558536,0.010075281,0.002749481,0.033385117,-0.023734104,-0.12973566,0.0070504467,-0.034749314,-0.019857207,-0.1476683,-0.121825114,-0.0043088105,0.12103763,-0.007952328,-0.014442247,0.015215642,0.006606856,0.011597945,-0.010655348,0.0073785293,0.07213401,-0.044130363,-0.0012827776,0.037664972,0.11704114,0.020620607,0.015288002,0.11256139,-0.017258272,0.049070794,-0.099599935,-0.030837025,0.05418374,0.086232945,0.027753435,-0.052386593,-0.018798318,0.07937449,0.021570025,-0.07621484,0.0154312225,-0.043423302,-0.04838591,0.042667482,-0.058734953,0.009985706,0.003621401,0.07282508,0.045346264,0.08211349,-0.05616069,-0.019946676,-0.009854716,-0.044676144,0.001562685,-0.054598745,0.069968514,0.094072014,0.07378896,0.018745245,-0.017680101,0.016050804,0.02097284,0.08760869,0.018065449,-0.051384192,-0.03837277,-0.045429304,-0.009329373,-0.031293627,-0.023771709,0.02290108,0.021588832,0.018303942,0.05884205,-0.050430704,-0.012317054,0.10116647,-0.022838071,-0.06513576,-0.045164783,-0.015976513,-0.01971935,-0.08434029,0.095082544,-0.04423142,-0.06213025,0.004976639,0.050692864,-0.0607843,-0.09951958,-0.08089344,0.0027543788,0.026496263,-5.4002376e-33,0.062286127,-0.0038463369,0.07028554,-0.09987607,-0.089713074,0.07666045,-0.025969831,-0.037229225,0.022006417,-0.028323606,0.094407946,-0.022694025,-0.037575636,-0.07067293,-0.008367952,-0.061365962,0.0017450432,0.047353573,-0.07792021,0.011106114,0.02609577,0.069075115,0.012950757,-0.009150932,0.08346836,0.0310955,0.006276003,0.07670452,0.051037636,0.07839492,-0.053212546,0.018315205,-0.044955734,-0.0618799,-0.034658667,0.12349866,-0.07315989,0.00421701,-0.0038856869,0.0044982494,0.044041637,-0.007586419,-0.020387456,0.044209737,-0.0020909626,0.05723471,-0.051138483,0.02203415,0.07985747,-0.057815824,0.008464493,0.028904395,0.033291638,-0.009808899,0.014409863,0.024993466,0.041416395,-0.038000986,-0.0032665106,-0.06939065,-0.008382639,-0.035892736,0.05675855,-0.070993654,0.035758093,0.06867176,-0.02155219,0.038109895,0.045664888,-0.03428128,0.03360675,0.0018308167,0.0054180836,0.0098066265,-0.01015521,0.024376316,-0.08179454,-0.08002994,0.029331127,-0.008327696,-0.011981526,0.011508377,-0.019503703,-0.02698196,-0.0450681,-0.047159944,0.0037929805,0.026775725,0.017936774,-0.015365292,-0.04521541,0.020281784,-0.037659883,0.060312707,-0.0474557,-4.4995115e-08,0.023234982,-0.060659792,0.036825024,-0.08182714,0.0017985641,-0.0003042607,-0.0851183,-0.023238305,0.0091478,-0.020033145,0.007521568,0.07628172,-0.03521433,-0.049972303,-0.041191585,0.016624121,-0.07553815,-0.008709018,-0.02991754,-0.04080908,-0.08354132,-0.043485444,-0.10729957,0.04127245,0.055438396,-0.07646988,-0.025990276,0.056252494,-0.026306598,-0.01657132,0.09497239,0.028890036,-0.0775897,-0.010796992,-0.08358739,0.0069108517,-0.10478129,-0.032024045,0.007558207,-0.024632134,0.042201355,-0.005475125,-0.038527753,0.028365683,-0.09112409,0.037388608,-0.029258877,0.006018476,-0.0834451,0.03528627,0.09147091,-0.0003789709,-0.023661679,0.01839678,-0.11443276,-0.003542107,0.041360985,-0.052195895,-0.038663566,-0.040287595,-0.016781826,-0.06989841,0.16958863,-0.057026178 +2.1.1.103,The enzyme may catalyse the transfer of two further methyl groups to the product.,384,0.99999994,-0.020678513,-0.012220592,-0.09035104,-0.016251585,0.07360089,0.040513057,-0.041270398,-0.0077049183,-0.04012491,-0.065639414,0.064753875,-0.052696705,-0.04276983,-0.01601775,0.019773852,0.109059736,-0.10936645,0.025296342,-0.061668996,-0.022353549,0.09182226,-0.037939683,-0.04077551,-0.034386013,-0.021966761,0.064612545,0.012578451,-0.03897235,0.032400314,-0.06861152,-0.017758396,0.021238798,-0.023533998,-0.029623557,-0.007568838,0.098076284,-0.030618062,-0.016004289,-0.021334648,-0.010663682,0.07113485,-0.0028620253,-0.014718671,-0.06432332,-0.10573899,-0.037538137,0.057124343,0.009676346,-0.013039764,-0.01614606,-0.027814852,-0.09865414,-0.031886064,0.021043347,-0.016394174,0.061557323,-0.01827154,-0.032489337,-0.08017518,0.024284335,0.031286392,0.0102933375,-0.094708495,0.02374043,0.03947405,-0.08521495,0.038875785,-0.03346735,-0.05318725,-0.03210871,-0.05333763,-0.08268894,-0.056449518,-0.0073169554,0.03846073,-0.047301322,0.048099343,-0.029832693,0.08243993,-0.025156094,0.0021396214,0.03775604,-0.005526945,0.015688164,0.058382917,0.0801572,-0.023418676,0.030149667,0.03518235,0.021278875,0.019923124,0.009629819,-0.024730194,-0.022309743,-0.045534734,0.04922033,0.04240691,0.022949249,0.08547693,0.03001437,0.016928842,0.051952,-0.12086685,-0.11552309,-0.03348793,0.0079263775,0.014209684,0.06235544,0.014825107,0.030351857,0.0004650614,0.07813491,0.06778382,0.051169384,-0.052037157,0.102483146,0.019767884,-0.028761052,-0.042937886,-0.031847436,0.010844063,-0.003205507,0.07253073,0.052748505,-0.028616384,0.024059042,-0.1299283,-2.990897e-33,0.011881181,0.038919736,-0.007969103,-0.02989877,0.023151964,0.028268937,-0.049835578,0.058636498,-0.001388505,-0.04789304,-0.1021129,-0.12705769,0.030699553,0.020333763,-0.06562569,-0.039075334,0.00915315,0.008057613,0.05075526,-0.025541594,-0.012881518,0.07634921,-0.06464911,-0.010728277,-0.0055498728,0.04075654,0.01107394,0.0075722835,0.06620704,-0.017904153,0.0021916165,-0.06328176,-0.12438071,-0.011876134,0.011057601,0.07369548,0.010243137,-0.02714028,0.040428776,0.06885563,0.047866095,0.015734024,-0.013050643,-0.009076245,0.011745622,-0.038825482,-0.059946213,0.04471689,0.05393643,0.009141728,0.001303978,-0.02152373,0.042888332,-0.081634045,-0.071081966,-0.011687838,-0.017728955,-0.019673966,-0.006693769,0.054838922,-0.068660825,0.035892706,-0.003813197,0.06072936,-0.0016327538,-0.031712685,-0.0508889,-0.016425787,-0.0028012244,0.072453424,-0.07394974,-0.009064365,0.08467161,-0.021951662,0.03577503,-0.056287363,-0.05902983,-0.028543556,0.09168075,0.0449048,0.010840306,0.0016522299,-0.0034887337,-0.05248981,-0.09830711,-0.012686956,-0.02206343,-0.07014371,-0.06266169,0.03541489,0.02501685,-0.041591484,-0.024319587,0.022715665,0.02836571,-1.5761515e-34,0.05242325,-0.068373464,0.07176946,-0.0973282,0.00035752094,0.0047180923,0.07354631,-0.0525632,-0.018563824,0.03330429,0.0584833,0.017897176,0.04177997,-0.012179117,-0.0014545942,0.03299218,-0.01271915,0.08660232,0.001707375,0.000214646,0.015063834,0.0899015,0.0014519392,0.0969936,0.007493642,0.0041365162,0.021629779,0.07953051,0.080575965,0.06696162,0.021039382,-0.10058743,-0.04713857,-0.019640695,0.013845906,0.12173245,-0.019421233,-0.014280826,-0.02385823,0.029527297,0.0019633695,-0.01988467,-0.007871694,0.06832108,0.006334955,0.08045879,-0.0315281,-0.03222116,-0.013188848,-0.049143903,0.079933226,0.03907656,-0.031960085,0.0026627798,0.024709752,0.032318342,0.063845806,-0.03476219,-0.042781614,-0.07203349,-0.07232072,0.008739662,0.013949561,-0.082429856,0.011177645,0.030152638,0.034729376,-0.0032703467,0.017126108,-0.009117982,0.06380227,0.055391375,-0.0024544762,0.015212425,-0.033655576,-0.07843721,-0.0556204,-0.049935095,-0.06725911,-0.065118894,0.006468913,-0.03229278,0.04905749,-0.043371353,-0.030486688,-0.05915236,0.057050887,0.08513581,-0.026368521,0.0019451978,-0.039938837,0.036251888,-0.012930429,0.06803566,0.0893139,-2.2876193e-08,0.016656334,-0.15101911,0.035741713,-0.05480412,-0.05726793,0.10484487,-0.10147404,0.002282652,0.035226215,-0.022529965,-0.07023277,0.10729583,0.015999926,0.09225862,0.013184264,0.013735561,-0.025378808,-0.03857454,0.0024078155,-0.08399181,-0.10276737,0.0408385,-0.030974856,0.032210346,-0.0053189923,-0.016642313,-0.0029281646,0.12569611,0.034717005,-0.05442092,0.010855113,0.046876755,-0.021132436,0.069534324,-0.016595993,0.013124752,0.019513385,-0.00028858954,-0.0059944578,0.044115204,0.051457517,-0.008947838,-0.08721472,0.05615692,0.010144487,-0.03972219,-0.009667535,0.008586744,0.04495041,0.050208434,0.10711062,-0.014566055,0.007930393,-0.018680273,-0.07790655,-0.031906884,-0.08979449,-0.039504774,0.014719144,0.004821861,0.07139686,0.039762385,0.1928793,-0.06583293 +2.1.1.105,Involved in the biosynthesis of phytoalexins.,384,1.0,-0.022842428,-0.038909353,-0.0765447,0.08388461,0.025461884,0.08659411,-0.06674591,-0.018237999,0.089301065,-0.030160712,0.044384636,-0.033543877,0.009974026,-0.020299762,-0.02472487,0.040522378,-0.0744468,0.06578573,-0.061702475,-0.036554214,0.051051803,0.05128563,-0.074502476,0.004169526,0.03903798,-0.072800525,0.021626346,-0.054835122,-0.010512342,0.018962016,-0.042587224,-0.13206284,0.00094108656,-0.049851675,-0.051534403,0.093654945,-0.05413119,-0.10037652,0.15659653,-0.016073238,0.011705574,0.021348001,-0.066509634,-0.006562016,-0.011617776,-0.00011907077,0.0029648042,-0.054620784,0.025622604,-0.06751609,-0.07605562,-0.037125655,-0.052013684,0.026498577,0.018789731,-0.0031704484,-0.04452849,0.06229725,0.06011603,0.037339903,-0.01409232,-0.02302935,0.0330399,0.010039948,-0.030902993,-0.0053739413,-0.058089495,0.0127086425,0.012622405,-0.08908786,-0.027749628,-0.055582415,0.017672267,0.05281761,0.052108977,0.036626026,-0.057111144,0.100337595,-0.050643917,0.008237723,0.065079086,0.024515271,0.023567103,0.12973015,0.047912665,0.027325464,-0.005301997,0.048234746,0.011978021,0.042597007,0.103293754,-0.01791326,0.035623807,0.030548949,-0.0014276567,0.022359096,0.041961886,0.03971494,-0.027753055,-0.06901149,-0.016375812,-0.008591648,-0.0861396,0.00896344,0.060886428,0.018804224,-0.0048255087,0.031107476,-0.023877753,-0.008675952,0.03994092,-0.041852698,0.0020253526,-0.0387129,0.01581212,0.06361308,0.004013875,-0.012081943,-0.011786623,0.007888071,0.053893372,-0.019485593,0.040350508,0.03287611,-0.06630344,-0.04176005,-0.058912504,-1.3413548e-33,0.010342179,0.025229491,-0.038686763,0.0016912777,0.09083353,-0.09914646,-0.0022511757,-0.0405058,0.07778539,-0.0256934,-0.0990975,-0.04718584,-0.029830275,-0.014285063,0.006488037,-0.009095064,-0.05295316,-0.062938996,0.08725917,0.017691758,-0.029298743,-0.05926384,-0.016904248,0.072542116,-0.04326404,0.0033455594,-0.055882324,-0.007392714,-0.02159082,-0.026981667,0.017593808,-0.107696295,-0.019872045,-0.0030487226,-0.02823498,-0.033574495,-0.010356642,-0.06586811,-0.08811783,-0.0127342325,-0.036285788,0.04372187,-0.0676626,0.008504472,0.08766851,0.065177955,-0.08641008,0.09031252,0.03780886,0.004808423,0.0083968025,0.0348221,0.11987374,0.05147463,-0.058098275,-0.030245492,0.005867556,-0.08418282,-0.011013231,0.06677792,-0.022392614,0.01508847,0.043909814,0.06041505,0.013535949,0.04279234,-0.026934544,-0.0064819986,-0.025749333,0.010783069,-0.034438025,-0.063081816,-0.019522429,-0.05571793,-0.017780643,-0.04382415,-0.04020096,-0.034363244,-0.051140238,0.004643895,0.058694728,0.029111138,0.023462038,0.057092346,-0.0055271927,0.006290147,-0.02288885,-0.0486601,0.061358754,0.023425827,0.017441198,-0.035783313,-0.03529645,-0.00083809084,-0.06950542,7.835918e-34,0.07580409,-0.03404466,0.024147792,-0.01487102,-0.037472464,0.031707603,-0.062627174,0.07830299,0.053485543,0.056906357,-0.019370858,0.00023193432,-0.020614773,0.05598868,-0.038827643,0.058018442,0.024298623,0.0908821,-0.004953444,-0.022987328,-0.06003136,0.021689463,-0.006211738,-0.0125396615,0.07693228,0.080896884,-0.018780405,0.066172846,0.03899358,0.009824867,0.0057861176,0.015392587,-0.037784755,0.028640078,0.019679824,0.0754337,0.019905346,-0.00059446675,0.0595554,0.07731959,0.053412147,-0.013170422,-0.022123534,0.009569182,0.035130292,0.049038082,-0.032657564,0.053036924,-0.037472617,-0.0717301,0.055709872,0.08658332,0.0020732272,0.07641514,-0.020923393,-0.0074227303,0.08517472,0.041293472,0.060074326,-0.046882417,-0.024687747,-0.04622528,-0.0140362615,0.0055879876,-0.0048844046,0.02886488,-0.04056996,0.08956829,0.014283289,0.006978285,0.050759178,-0.03814972,0.032871556,0.010630011,-0.073627524,0.022929799,-0.037589986,-0.010252357,0.046467345,0.117241,0.017036969,0.06325369,0.05206178,-0.09414746,-0.03259165,-0.042947814,0.05117251,0.11138527,0.015047882,0.019666031,0.015403303,-0.07055838,0.0036114738,0.057518184,0.09633578,-2.077551e-08,0.030303039,2.5677857e-05,-0.012062543,-0.0070914174,-0.003744298,0.0038605887,-0.021785716,0.033108763,-0.026101358,0.012318985,-0.059341278,-0.016432174,-0.021131199,0.01947783,0.0045414516,0.055740654,-0.03029275,0.03770374,0.017785328,0.013402027,-0.054303583,-0.0061595705,-0.10692774,0.0017715606,0.014505253,-0.13516934,-0.026734017,-0.021284977,-0.016927825,0.032992087,-0.0010267283,-0.019566206,0.02245335,-0.10034297,-0.12716536,-0.0033091719,-0.07252187,-0.10056078,0.026250226,-0.029640023,-0.10671386,-0.083842225,-0.027537977,0.010798224,0.037858754,0.01824489,0.019616142,0.009319954,0.01186525,-0.032868683,0.058331892,-0.062449727,0.07862286,-0.082880326,-0.10944859,-0.024569293,0.042988848,0.0073201675,-0.04985114,-0.100466356,-0.09459688,0.09545722,0.22305745,-0.02869554 +2.1.1.106,"The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis. It is a radical SAM enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. It has an exceptional reaction mechanism as the S-adenosyl-L-methionine (SAM) is not bound to the [4Fe-4S] center and does not produce a 5'-deoxyadenosyl radical but instead is believed to be involved in binding of the L-tryptophan substrate. After transfer of the methyl group from methylcob(III)alaminIn a methyl transfer from SAM to the generated cob(I)alamin takes place, preparing the enzyme for the next catalytic cycle. The original methyl group configuration is preserved.",384,1.0,-0.07734858,-0.038522564,-0.15880561,-0.0037969945,0.021132201,0.06406863,-0.06923154,0.014863356,0.03033388,0.009396459,0.023132777,-0.0054758103,-0.054153156,0.039723575,-0.039908584,0.029662412,-0.05404088,-0.013424385,0.029477114,-0.04544173,0.056507654,0.046360366,-0.036296744,-0.034863524,0.014019851,0.044463042,0.012147069,0.009806429,0.0077541005,-0.05567842,0.008542301,-0.013050373,0.043202337,-0.02542416,0.056625932,0.12543051,-0.012936386,-0.0663745,0.11547676,-0.010186179,-0.012917948,0.028759984,0.014168198,0.044946257,-0.06151699,-0.019799098,0.039683916,0.020660995,0.055561528,-0.0895229,-0.061437402,-0.05076858,-0.0336964,0.044508204,0.064242706,0.036658343,-0.032103375,-0.044386826,0.019566165,-0.051876802,0.06953708,-0.038354166,0.028839298,-0.013825904,0.0056030774,-0.009368732,-0.03221733,-0.07944879,0.075203866,-0.023537088,-0.045633648,-0.010741175,0.0062840907,0.030167077,-0.018975418,0.009226662,0.029969348,-0.052309167,-0.013060891,-0.03779385,0.039629277,0.015443614,0.042041242,0.028231934,0.025875038,0.030011047,-0.013642576,-0.01998823,0.041943006,0.046374362,0.061175745,-0.025418848,-0.02704017,-0.111309715,0.015421555,0.009984299,-0.018096283,-0.015219559,-0.01199433,0.02349508,0.04016857,0.054760847,-0.049701694,-0.047871422,0.026339764,0.011776254,0.0041473685,0.09445195,0.013418876,0.024179325,0.036016375,0.06748159,0.04695885,0.030685067,-0.008634115,0.051543906,0.04306246,-0.046346758,-0.020804862,-0.017338784,0.013520756,0.02867213,0.032773767,0.060699824,-0.04251118,0.03962219,-0.14749596,2.4053353e-33,0.086541,0.06962435,0.018982211,-0.058914088,-0.027356585,-0.07046161,-0.108475775,-0.016824003,0.010907363,0.011146588,-0.08959494,-0.10703035,0.05689377,-0.04087393,-0.06606095,-0.06327801,-0.10137957,0.01591089,0.039756153,-0.01982996,-0.060211707,0.0025449556,-0.08110154,-0.017461246,-0.032679465,0.09816015,0.018694732,-0.0033345013,0.04284058,0.016352702,-0.032372117,0.008479735,-0.11545215,0.037565835,0.054930866,0.0020399785,-0.029414747,-0.056099493,0.051381435,0.04893496,-0.012608855,0.036565993,-0.033834446,0.060796212,0.07777847,-0.078148395,0.00095081644,0.112087995,0.072991334,0.05725701,-0.027940765,-0.09321157,0.10811248,-0.0296853,-0.11792564,-0.014653727,0.054674517,-0.05106525,0.046588093,0.08488581,-0.029728392,-0.026338553,-0.058685236,0.07263491,0.0076977643,0.006535189,-0.06811255,-0.046701252,-0.025877384,0.09471796,-0.008942005,-0.004952653,0.09879442,-0.008517893,-0.004727397,-0.003637211,0.0018337725,0.03857824,0.031582173,0.03424345,0.05225009,0.020653961,-0.045576796,-0.069848344,-0.043883797,0.039684676,-0.024855683,-0.097259015,-0.012986497,0.05632366,0.018043282,-0.05868899,-0.024039242,0.010460318,-0.02666997,-3.1762313e-33,0.08732143,-0.084324576,0.041254163,-0.08604433,-0.08894084,0.041341916,-0.023430998,-0.04544192,-0.02700345,-0.08137376,0.10122709,-0.04034235,0.034935698,-0.07171301,0.018548619,-0.039273635,0.0072995117,0.03902459,-0.011248018,-0.008398345,0.07514569,0.03573512,-0.009726324,0.0016211784,0.05943756,-0.014887221,0.014014235,0.086741365,0.06672342,0.06703008,0.03940895,-0.0888273,-0.0760792,-0.012267895,-0.046847563,0.06610812,-0.10878818,0.03592667,0.01841048,0.021945272,0.062445763,0.05237974,0.03068229,0.11238015,0.04831383,0.10444041,-0.07146849,0.02954549,0.01236429,-0.09532889,0.006566974,-0.029286206,-0.04442678,-0.02530805,-0.035325464,0.118622854,0.07107421,-0.036622528,-0.045308024,-0.032146037,-0.027541101,-0.06487671,0.058018856,-0.03642978,0.029962255,0.010116553,0.029629469,0.060275443,0.09031397,0.031737726,0.021181986,-0.012458278,0.024317566,0.013044352,-0.018882008,-0.012088597,-0.08430542,-0.0050210576,-0.014331192,-0.037837707,-0.029055977,0.027232597,-0.0059649325,-0.035595745,0.03528715,-0.0043908814,0.04949926,0.122308314,0.038686518,0.017006652,-0.08804103,0.021776253,0.011537681,0.039660197,-0.01741126,-4.8998444e-08,-3.0399804e-05,-0.06424691,0.03879494,-0.0045086034,0.022650797,0.10486626,-0.027795695,-0.04022235,0.032227185,-0.037797894,-0.061711024,0.090505056,-0.037474148,-0.015585852,-0.030618563,0.015782377,-0.065683566,-0.036659252,0.024610203,-0.06988494,-0.09097741,-0.044132322,-0.04473734,0.039297648,-0.01374372,0.017079944,0.043173257,0.13154699,-0.00661695,-0.020142822,0.02109233,0.017088784,-0.10110468,-0.0025670624,-0.081813835,-0.010204521,-0.07594099,0.0060735736,0.0012066232,-0.0012354745,0.032896202,-0.014817925,-0.08074747,0.09142782,-0.059679776,0.036504805,0.020880606,0.02912856,-0.018599559,-0.00022374582,0.055708285,-0.0396723,-0.04095001,0.026039181,-0.06720284,0.013293511,0.001662018,-0.06988732,-0.001933664,-0.0063759214,0.030256405,0.023843065,0.07633641,-0.03115627 +2.1.1.107,"This enzyme catalyses two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III. The second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76, precorrin-2 dehydrogenase) and the third step involves the chelation of Fe2+ to sirohydrochlorin to form siroheme (EC 4.99.1.4, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction. Also involved in the biosynthesis of cobalamin.",384,1.0,-0.096470736,-0.051695347,-0.08232678,-0.03433554,0.050915346,0.03173015,-0.11389025,0.019642932,0.044916376,-0.011280957,-0.044207674,-0.03184702,-0.07663156,0.018640265,-0.050159235,0.038206924,-0.10797359,0.005522384,-0.047044136,-0.059333652,0.15851188,0.034876443,0.010426243,-0.044319052,0.0008609639,-0.04845534,0.043437324,0.055188783,0.012320768,-0.028045904,0.071220584,0.015623301,0.023544623,-0.048973706,-0.022201227,0.13019209,0.058212433,-0.019995153,0.07360892,0.005456793,-0.021815766,0.002265069,-0.07602664,-0.002573086,-0.010480663,0.0052673365,-0.00780936,0.054365907,0.010479214,-0.07669424,-0.027522165,0.012163878,-0.016817031,-0.027258014,0.0151037695,0.011677547,0.0050001326,-0.07417149,0.02793834,-0.02753355,-0.066664934,-0.07773439,-0.024093764,0.0053942264,0.056487408,-0.010476084,0.02759313,-0.14239508,0.057975892,0.0031851472,-0.043456882,-0.044976823,-0.05008227,-0.024561813,-0.035905402,0.07156744,0.0020303996,-0.029745908,0.0062918123,-0.06363949,0.04548459,0.025384802,0.062944315,0.056248464,0.06055707,-0.052468713,-0.06305964,0.013446336,-0.016684286,0.012668426,0.035216637,0.05314877,0.013851612,-0.0041742628,-0.040297758,0.06640331,0.005374287,0.012535251,0.048002567,-0.04054833,0.050859254,0.026912495,-0.056133714,-0.048365634,0.05363223,0.00225903,0.044360526,0.18616898,0.022477653,0.04824297,0.008478557,0.0029433048,0.037553843,0.021563046,-0.06972741,0.10574947,0.035644583,0.026524415,-0.039333012,-0.046076942,0.035562407,0.048742097,0.013258216,0.046623304,-0.08857471,-0.008728792,-0.08545341,4.6069346e-33,0.08319857,0.035073783,-0.058922596,-0.005481546,-0.053226627,0.019455466,-0.052156303,0.052194547,0.01739761,-0.06906978,-0.009873743,-0.053552426,-0.02431078,-0.048307274,-0.0799189,-0.05325,0.016585179,-0.0025313476,0.044402733,-0.0061865705,0.020927172,0.0992053,0.02593084,0.00252581,0.03495147,0.079394795,0.0056061186,0.023828192,0.0029419628,-0.012696322,0.0037621793,-0.11150076,-0.086937994,-0.00513384,0.053137213,-0.010491088,-0.047527038,-0.0064562317,0.006120175,0.044919953,-0.13263914,-0.0020183185,-0.04418214,-0.084129244,0.035444703,-0.06362759,-0.06329364,0.068528354,0.0026029104,0.034962542,-0.035096407,-0.009782307,0.09116767,0.021334333,-0.04404822,-0.029265322,0.0299852,-0.0272531,0.011370016,0.071763285,0.030967003,0.07157855,-0.010728218,0.121556655,-0.015447603,-0.05913811,-0.023209797,-0.03860997,0.037461195,0.11665243,-0.032833334,0.055792596,0.09456592,0.015081447,0.058857456,-0.018055042,-0.026057815,-0.012081842,-0.0016873605,0.04395783,0.02190508,0.038401175,-0.022442231,-0.01723205,-0.042599738,0.010933368,-0.0101010045,-0.100749634,-0.05037303,-0.013322426,0.006518555,-0.0900756,-0.023855519,0.016514048,0.008932016,-6.280651e-33,0.13778381,-0.038315322,0.14710045,-0.09637588,-0.08961726,0.09559446,0.01806871,-0.101865984,-0.032536343,-0.043303117,0.021966005,-0.016639885,0.05938385,-0.08535501,-0.023799969,0.015444372,0.033963267,0.096474595,-0.000738799,0.02646575,0.0023972574,0.107198246,-0.03627038,0.061714035,0.04720809,-0.03789147,0.0346501,0.0076336763,0.03864991,0.07360301,0.0013538792,0.033154022,-0.02862695,-0.04456981,-0.0084067285,0.07667684,-0.044257753,0.018548544,0.042308036,0.03586783,0.003503718,0.021724049,-0.033133417,-0.010954522,0.04546156,0.026364468,-0.10255563,0.028824184,-0.043072004,-0.03364339,-0.0004970926,0.021823538,-0.08462372,-0.011186966,0.053504907,-0.021725686,0.051118128,-0.0053700786,0.033591587,-0.03881085,-0.03389917,-0.045353357,0.044984024,-0.043285497,0.0076960074,0.09262909,6.949041e-05,0.050632257,0.07439637,0.04138351,0.0022024375,-0.020813571,0.06760759,0.015427044,-0.01763224,-0.0019754076,-0.062052343,-0.06324945,-0.032001246,-0.039344482,-0.017061764,-0.0032505372,0.023984563,-0.023783296,-0.051241644,-0.096671365,0.09248253,0.099521406,-0.055661313,-0.019945605,-0.028953103,0.06925114,-0.025766864,0.044889927,0.054967184,-4.6951314e-08,0.06499779,-0.08559717,0.0396096,-0.04947415,0.012635283,0.035067078,-0.04412778,-0.017374292,0.036418244,-0.023071934,-0.012039788,0.08532104,0.022670519,-0.029553408,-0.018788407,0.016782746,-0.056473695,-0.015344259,0.02897224,-0.026013957,-0.036801323,0.015270568,-0.108455725,-0.007985105,0.026654832,-0.09490907,-0.0114901075,0.015466302,0.03610897,0.03134835,0.022596616,0.029436817,-0.032169417,-0.020424409,-0.011495851,0.03958485,-0.05480998,-0.029132634,0.031977434,-0.0039534797,-0.030578576,0.0054856744,-0.050747503,0.06003198,-0.00273577,-0.015250339,-0.038195066,0.040344328,-0.0137725705,0.025185103,0.020213617,-0.0389812,0.05734564,-0.050825786,-0.07726731,0.059532393,-0.052204072,-0.11808816,0.004065288,-0.020040361,0.029391367,-0.010001508,0.09657762,-0.08118082 +2.1.1.108,"3,4-Dehydro-6-hydroxymellein can also act as acceptor. 6-Methoxymellein is a phytoalexin produced by carrot tissue.",384,0.99999994,-0.013390889,-0.12875926,-0.021403776,0.017692963,0.06604339,0.06348471,-0.058868278,0.019823061,0.07603866,0.0043167574,0.06254182,-0.01054424,-0.07329561,-0.07487377,-0.061046924,0.06633247,-0.023762416,0.01935342,-0.0815804,0.031264886,-0.011312918,0.11373219,-0.035506777,-0.022389436,-0.043204296,-0.08373056,0.06413367,0.009133666,-0.047904022,-0.028714443,-0.020552471,0.023838898,-0.019313745,0.10321057,0.002986364,0.065196216,-0.020302258,-0.094607234,0.047200292,-0.018310687,0.028559817,-0.06482518,0.06510934,-0.066219896,-0.030272,-0.01571927,-0.09507189,0.020956017,0.12899084,-0.08788142,-0.016339127,-0.020285813,0.008848731,0.032836754,0.022553876,0.041683625,-0.051717356,0.036788546,0.00072177366,0.070780315,-0.019627804,-0.007355947,0.03811218,-0.022458613,0.015888361,-0.06665812,-0.051206328,-0.06606154,0.0008341773,0.055989645,0.020543259,-0.0038122255,0.04227793,-0.008427052,-0.013471299,0.0070480118,-0.103421524,-0.009839578,0.09184963,-0.035210405,-0.0014454052,0.09965183,0.06701537,0.098683596,-0.011930737,-0.0430348,-0.025968798,0.012614538,-0.03317785,0.062140893,-0.002401478,-0.044970613,-0.04724551,-0.022858763,-0.075452015,0.011844594,0.15963516,-0.067213565,0.006103133,-0.0077263294,-0.07812552,0.024552623,-0.06982471,-0.07247535,0.028087096,0.026371771,0.008998496,-3.9850065e-06,-0.011099886,0.03464814,0.022526972,-0.046940014,0.03288821,-0.06341853,-0.037106324,-0.0025890456,0.002955071,-0.08405175,-0.00514544,-0.024951035,0.019928247,-0.017754642,0.017361421,-0.0034357412,-0.07051893,-0.025923943,-0.021807037,7.760196e-34,0.019006344,-0.04002446,0.014455997,-0.010012756,0.016363198,-0.029686656,-0.015171936,0.024691004,0.02301595,-0.06632041,-0.08589608,-0.045334924,-0.0070851417,0.011149607,0.00016045947,0.018763881,-0.07865598,0.018295325,0.075280525,-0.017413683,0.033341955,-0.0124726,-0.048889086,-0.053822402,-0.13383037,-0.027046759,-0.042324703,-0.09217846,0.13169149,0.0055219517,0.017680487,0.004114691,0.022079144,0.030939607,-0.039626144,0.06497127,-0.031027818,-0.026480677,-0.008495225,-0.016077505,0.050438985,-0.044897523,-0.069649205,-0.06185638,0.034296423,0.035401274,-0.010301252,-0.015223986,0.018793253,0.0023751177,0.06644167,0.0048094764,0.12418774,-0.072991796,0.018966505,-0.06972888,-0.018923832,-0.002488505,-0.005667097,0.0774625,-0.027829507,0.042365864,-0.027254956,0.0592911,-0.03055155,-0.054162487,-0.0792741,-0.03824022,-0.009835601,0.063674055,-0.005117535,-0.07819765,0.0175214,0.007001469,-0.035476442,-0.028790494,-0.015500333,0.046023406,-0.015614838,0.018743582,0.0012965892,0.016982188,0.009978682,0.081028156,-0.04941277,0.06083924,-0.103468835,-0.02514002,0.0027650108,0.009026914,0.01266181,-0.11141307,-0.040745057,0.020387284,-0.030383557,-2.6810817e-33,0.01467241,0.019644894,0.016569179,0.009944856,0.05117678,0.12288668,-0.04268806,0.009315341,0.06611207,-0.018607682,0.017076878,0.015917333,-0.014285433,-0.049642716,-0.009092235,0.056106407,-0.051568158,0.055363875,-0.05882267,-0.012078461,-0.053357977,0.014111452,-0.01658163,0.065892935,0.035598576,0.08001861,0.04035355,0.025646757,-0.024340775,0.09733219,0.071004055,-0.015817832,0.02850171,0.07435102,0.0008606301,0.00785926,-0.106761165,-0.055093173,0.011334624,0.03744801,0.042690493,-0.02691302,0.01730212,0.071921006,0.104360156,0.012411841,0.008263183,-0.010030357,0.06397378,0.033091657,0.03378994,0.01399304,-0.08533779,0.020098053,0.011957506,0.030687436,0.01302045,-0.07665441,0.023807704,-0.03285062,-0.08178058,-0.0075867823,0.055339567,0.02305628,-0.0032363688,0.021667613,0.044197362,0.09355047,0.01347669,-0.031365152,0.05752238,0.071319245,0.05547431,0.014718976,0.080287665,-0.037763424,0.039107483,0.01871842,-0.028656675,0.05262309,-0.014567291,0.036402516,0.056562748,0.001685257,0.025193974,-0.0037637998,0.048427004,0.05776923,-0.058983896,0.066222474,0.018121073,0.042419072,-0.080269866,-0.00066265074,0.064973824,-3.141043e-08,0.14004993,-0.06274919,-0.0012596803,-0.10348485,-0.018595545,-0.0212037,0.0058007585,0.092838645,-0.03856281,-0.017062733,-0.009325011,0.0011367636,-0.056333564,-0.02003637,0.037517134,-0.04114719,-0.019728864,0.015020102,-0.069415554,-0.035114367,-0.10912955,-0.01289664,-0.020835781,0.007278791,-0.04923296,-0.029238867,-0.04371885,-0.051279977,0.023411445,0.003951702,0.035423856,0.0959488,-0.1025817,-0.0054295957,-0.05032478,0.03938532,0.026958296,-0.04475311,-0.05913126,0.050151374,-0.03000155,0.010053745,-0.060786255,-0.034356125,-0.0149885705,0.022547886,-0.02550188,0.013643057,-0.025516775,0.051405445,-0.023003021,0.021679437,0.061213188,-0.0039830445,-0.07850511,-0.0059533254,-0.025679562,-0.03552191,-0.06302391,-0.07632811,-0.0009156921,0.034668516,0.23194344,0.11566564 +2.1.1.109,Dihydrodemethylsterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.,384,1.0,0.012405628,-0.010476703,-0.096845135,0.018012414,0.09371917,-0.015706023,-0.050440665,0.041513283,0.010110195,-0.0035992481,0.030117858,-0.067876734,-0.10389761,0.05240539,-0.0718416,0.01878322,-0.122473866,0.05378033,-0.022591688,0.053424377,-0.0039191814,0.013882609,-0.03341165,-0.009228303,-0.009270833,-0.043122094,-0.026258681,0.08904253,-0.029853074,-0.073448576,-0.03429442,0.02564536,-0.016206866,0.012233013,0.007946798,0.07442922,0.0045786663,-0.05110312,0.06441923,-0.013459649,-0.01436424,-0.01546441,0.034278993,-0.009593819,-0.116157286,-0.028036177,-0.038817253,0.012225807,0.040906798,-0.016864626,-0.06368201,0.041804668,0.00999039,0.10651303,0.11010442,-0.0052312515,0.050598975,-0.033168957,-0.059113253,-0.0052753184,-0.0030151315,-0.04917893,-0.023271756,-0.026161533,-0.027982885,-0.035454128,-0.035931706,-0.06410248,-0.029072354,-0.05270847,0.0432406,-0.03708848,0.051900588,0.0013647875,0.07083462,0.11987374,-0.09635489,0.0074002254,0.01668306,0.010798879,0.06866115,0.029498205,0.10561806,0.037181873,0.06123328,-0.06132159,-0.06783422,0.019455908,-0.031785652,0.1187765,0.05418722,0.061406825,0.0681141,-0.022093866,0.01954922,0.03139691,0.082717225,0.006227645,-0.02444592,-0.006842766,-0.04790702,-0.01869746,-0.15359871,-0.02143134,-0.0013334365,-0.022657808,-0.007802862,0.008226125,-0.046657372,-0.019699652,-0.010363297,-0.035063345,-0.0073189475,-0.011878296,-0.009756613,0.00027322533,0.045576543,-0.0676942,0.0042888448,-0.049787387,-0.012853088,0.010943804,-0.0020709694,0.055202194,0.039901484,-0.027510209,-0.07559804,2.5477958e-33,0.027996361,0.05730807,-0.08368945,0.017187249,0.049439196,-0.061183285,-0.038761977,0.0073009534,0.03966709,-0.037758563,-0.10451058,-0.0087366365,-0.09104054,-0.012487991,0.0062754275,-0.060828187,-0.0048865858,-0.024061967,0.0074214144,-0.017863695,0.08176996,0.022707822,-0.052172877,-0.02329293,-0.006225669,0.06638427,-0.060114805,0.0034836954,0.06612647,-0.010471543,0.06946472,-0.045649398,-0.04322443,0.03470892,0.057634447,0.020006914,0.014494735,-0.0040301676,-0.08454658,-0.0260215,-0.03481607,-0.01963087,-0.047493115,-0.0670334,0.0605359,0.02331414,-0.05071951,0.01379498,0.049130473,-0.019636227,0.1186862,-0.016212402,0.061538056,-0.06963051,-0.007541748,-0.033203352,-0.02520938,-0.08584472,-0.032251466,0.07287198,-0.029580662,-0.032881472,0.007091251,0.0069659455,-0.008678186,-0.010683662,0.04254667,-0.09733681,-0.021640943,0.021760829,-0.029008718,-0.0360206,0.013969873,0.039324164,-0.011267301,0.033248536,-0.05433215,0.00014724827,-0.048635855,-0.03511322,0.031003822,-0.008199555,-0.03344496,-0.025358418,-0.07956083,0.035898443,-0.027202882,-0.02879887,0.050122026,-0.010808219,0.051804073,-0.02872715,-0.035766687,0.032375693,0.03624136,-4.7099836e-33,0.067923516,-0.084313594,0.039759383,-0.005899204,-0.03801337,0.15825044,-0.06320266,0.0053586536,0.10227411,0.013330506,0.019346338,-0.030263457,-0.046876103,-0.025244482,-0.022642056,-0.0030781473,-0.016619304,0.08360704,0.022244135,-0.0036266786,-0.097921506,0.05842121,-0.05149019,0.018488783,0.06237181,0.052563727,0.012843505,0.044733357,0.044247378,0.000110694404,-0.087484725,0.054824673,0.012186245,-0.05886983,0.010941364,0.07722844,-0.0720497,-0.003015651,-0.039161555,0.060930245,-0.0044733677,-0.018413296,-0.044392176,0.06698207,0.03308524,0.022899592,-0.03024223,-0.014017631,0.10991575,0.005772069,0.068432994,0.0428967,0.023822643,0.006226729,0.022239663,0.05384631,0.041638073,-0.034553364,0.044273295,0.00034668983,-0.026468655,-0.04271093,-0.0064467457,0.012369854,0.016908476,0.06471881,-0.07563527,0.0048640785,0.03987437,0.01839915,0.102742605,-0.001211386,0.05775174,0.09791323,-0.021929711,-0.0015417119,-0.018029325,-0.045173846,-0.0042137844,0.086990125,0.0046434645,0.091503955,0.04181301,0.0016253892,-0.038605385,-0.08841769,0.09237846,0.054296464,-0.10155386,-0.011360307,0.07568139,0.03672828,0.026383992,0.023585834,0.02395339,-2.9360615e-08,0.033867586,-0.010619003,-0.004988926,-0.097886086,0.009205167,-0.020558583,0.053663924,-0.0018389854,-0.0071329493,-0.02784908,-0.06752604,0.11133829,0.02584374,0.022635194,0.041279826,-0.007120039,-0.025533594,-0.05142913,-0.0018263465,0.022111801,-0.08800339,0.006160399,-0.0976694,-0.029116886,-0.048767775,-0.014862827,-0.013335916,0.06107003,0.05699112,0.11953532,0.02063513,0.020966584,0.009586276,-0.08872212,-0.114451766,0.013598149,-0.057371255,-0.12563372,-0.015461177,-0.07105047,0.021879237,-0.037204325,-0.059727427,-0.03354959,-0.055627182,-0.010636955,-0.06435755,0.02606246,-0.0009997399,0.04938146,0.105433024,0.021166615,0.017952817,-0.037465062,-0.0811203,-0.005995219,0.05621461,-0.011079995,-0.028276792,-0.050308518,-0.04681756,-0.018331714,0.20732886,0.023009935 +2.1.1.110,Dihydrosterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.,384,1.0,-0.00033699788,-0.014118673,-0.0827836,0.025952369,0.091518655,-0.024858277,-0.05436102,0.04543469,-0.00524953,-0.0039556124,0.019137664,-0.04269447,-0.09792806,0.05555457,-0.0865377,0.01775696,-0.104026556,0.06391827,-0.02337974,0.03584789,-0.0042987196,0.008775212,-0.017876562,-0.010519797,0.0011097247,-0.030079253,-0.010977412,0.093435444,-0.03796127,-0.074250445,-0.036756337,0.0037941637,-0.0010676531,0.012819107,-0.0075543607,0.087132476,-0.015474624,-0.04515315,0.07121767,-0.022050632,-0.015623507,-0.015813455,0.042807914,0.0047920803,-0.113332346,-0.047159396,-0.05276222,0.028770182,0.04830142,0.0010395536,-0.07694106,0.046666857,0.022921285,0.10966399,0.10952966,0.02102533,0.021558926,-0.023946097,-0.06087437,-0.013761845,-0.016196009,-0.04336004,-0.027687531,-0.022714887,-0.024285557,-0.040566992,-0.027592687,-0.045462906,-0.037727684,-0.042881314,0.05182445,-0.022192962,0.053347707,0.00090149493,0.065803744,0.11900822,-0.116550624,0.0039491416,0.019201914,0.026286531,0.06591195,0.020735586,0.106918566,0.02890803,0.037634544,-0.054971337,-0.050792146,0.017528769,-0.03851469,0.095140435,0.07646687,0.054048028,0.06094094,-0.022748148,0.037195113,0.020463731,0.08036439,0.0269144,-0.036476597,-0.011560014,-0.047116823,-0.0111272065,-0.13010068,-0.020350643,-0.009267325,-0.019136412,-0.0076801004,-0.0039435937,-0.04746879,-0.025025172,-0.0082722325,-0.0559145,0.01922543,0.01602448,-0.0031277898,0.010074192,0.039993152,-0.06732007,0.0028810427,-0.030204944,-0.0005592597,0.01637964,-0.000384595,0.056786656,0.030738346,-0.032902822,-0.07625973,1.2451418e-33,0.022817131,0.040777434,-0.092790276,0.027101642,0.04238855,-0.050417636,-0.043951437,0.0030798786,0.030911386,-0.027374119,-0.101362005,-0.0023889174,-0.08001161,0.0054954784,-0.0034408646,-0.06319752,0.011034605,-0.027493687,0.020896582,-0.001677677,0.07980804,0.047851145,-0.06714096,-0.021675983,-0.014574157,0.080637865,-0.069269285,0.0062547983,0.06488554,-0.010069368,0.07829407,-0.043986954,-0.051262464,0.034990452,0.044301584,0.011532173,0.023102636,-0.025184553,-0.104085885,-0.05144903,-0.047071442,-0.03061726,-0.06875283,-0.058164466,0.04674984,0.01041562,-0.0411925,-0.010586029,0.045661334,-0.02285325,0.1277885,-0.02386526,0.05776517,-0.07286741,-0.010594041,-0.042563014,-0.02714,-0.090914495,-0.013417105,0.07828416,-0.016268449,-0.026011644,0.016676512,0.012200472,-0.011000811,-0.01245434,0.027980868,-0.08650463,-0.027193872,0.03730531,-0.015476993,-0.03278813,-0.0017387493,0.043931264,-0.010908793,0.030123746,-0.06902661,0.019316548,-0.05136869,-0.057187174,0.029447516,-0.033674773,-0.026744876,0.008518907,-0.06976594,0.051081408,-0.040866293,-0.02485404,0.051898565,0.003762378,0.047737747,-0.021481529,-0.054417554,0.0296438,0.050145112,-3.5695565e-33,0.06649147,-0.093871705,0.04028185,0.0101838,-0.053389657,0.1720465,-0.046847742,0.008222577,0.10583328,0.0035417918,0.00076969026,-0.03573914,-0.035240814,-0.045073166,-0.011523511,0.015466086,-0.011663051,0.074929856,0.014106262,-0.012471914,-0.09512381,0.06100509,-0.05778091,0.0032970202,0.057445396,0.050973155,0.012437139,0.034319215,0.03562298,0.008319543,-0.087067924,0.058062628,0.006492466,-0.06378932,-0.005676628,0.079449214,-0.07390447,0.003924549,-0.04178091,0.047884353,0.0022197599,-0.013678712,-0.042296883,0.07174899,0.038173504,0.016482268,-0.010321362,-0.0029560046,0.095564924,0.011720795,0.060128283,0.054790467,0.036075406,-0.0027675198,0.029761637,0.05780214,0.040666386,-0.051323667,0.051491592,0.016396021,-0.031787734,-0.05164295,-0.015613995,0.01746059,0.019997764,0.06149444,-0.08801587,0.01730569,0.053411737,0.02411834,0.11198733,-0.015647534,0.068458624,0.103853874,-0.0031241903,0.020229623,-0.025603838,-0.029136855,0.013278705,0.07947733,-0.021292545,0.08668882,0.049569882,-0.010372158,-0.040292725,-0.0877713,0.0984812,0.056437407,-0.09743412,-0.015694173,0.08164304,0.017184073,0.010765758,0.0025076633,0.022631053,-2.6407212e-08,0.03589398,-0.01909163,0.0015167965,-0.091653116,0.01944019,-0.02214313,0.06872025,0.0051550986,-0.016791677,-0.019877464,-0.06682901,0.11366824,0.02221397,0.027002959,0.036730528,0.01416463,-0.01164824,-0.054753285,-0.0052498393,0.03520056,-0.078581,-0.006575578,-0.092160605,-0.019225083,-0.054471213,-0.019765858,-0.018997591,0.05422595,0.044829875,0.100166485,0.011054505,0.016792813,0.02130509,-0.11026295,-0.09940946,0.025210114,-0.04963206,-0.125362,-0.0001221835,-0.08342968,0.016125444,-0.042683635,-0.031901192,-0.039644144,-0.0741755,-0.016077368,-0.051492047,0.0075350823,0.015239081,0.048428245,0.099232666,0.024982115,0.022571128,-0.042710688,-0.07359381,-0.008053444,0.064392835,-0.0021534113,-0.017324466,-0.06166528,-0.036915027,-0.014508373,0.19257441,0.015664067 +2.1.1.111,Involved in the biosynthesis of acridine alkaloids in plant tissues.,384,1.0,-0.05604332,-0.021250024,-0.12301141,0.05934751,-0.025364336,0.061742943,-0.010370135,0.008813645,0.0904115,0.04401909,0.082810596,-0.04180862,0.004898203,-0.04060374,-0.11017354,0.03948602,-0.016567409,0.010019252,-0.060168535,-0.047438223,-0.00288957,0.079960205,-0.018144043,-0.01523392,0.045360867,-0.035324328,-0.10434808,-0.036769576,-0.044507552,-0.06288349,0.02953194,-0.0394908,-0.013141745,0.038437843,0.046924002,0.04046683,-0.06214924,0.021237133,0.14084184,0.06801458,-0.031491928,-0.029878467,-0.05280929,0.036238935,-0.063448235,0.00797139,-0.039792594,0.015056584,0.031867355,0.03206799,-0.02270356,0.04626474,-0.005641002,0.03453976,-0.08177299,-0.0743037,-0.003950176,0.07431213,-0.017114198,0.053013798,0.00835378,-0.046364922,-0.012211225,0.02101747,-0.11475766,-0.06233965,-0.022635741,-0.021459095,0.030275304,-0.036703743,0.040596824,-0.08422914,0.060799733,-0.043358125,0.061266072,0.04669023,-0.06569021,-0.04972094,-0.093654774,-0.037689842,0.058441807,0.0062637804,-0.026191844,0.048294406,0.013326048,-0.049433302,0.033059172,0.06946911,0.0058640027,0.04087618,0.08590824,0.018827844,0.03617522,-0.02171537,-0.029547693,0.108751066,0.0855192,0.020080796,-0.04449958,-0.080732085,-0.013808107,0.011493263,-0.078143276,-0.0044294544,-0.042552315,-0.06664147,-0.028506244,-0.030425144,-0.029851893,-0.025304735,-0.0060702777,0.0037407815,-0.062239017,0.0339203,0.04633001,0.043158006,0.023576783,-0.04937096,-0.026381088,-0.027605725,-0.08004372,0.01804185,-0.017971687,0.07065841,0.031221038,0.017129386,-0.013046156,-1.0908391e-33,0.02812695,0.11519546,-0.12195081,-0.03541597,0.07549393,-0.05583016,-0.07911703,-0.0017800791,0.00088989706,-0.0060081356,-0.078665525,-0.03625526,-0.015644167,-0.04381666,-0.00056882383,0.018883826,-0.07867298,-0.039370075,0.07816651,-0.051825374,-0.03379875,0.0146821495,-0.056532573,0.09577394,-0.06783165,0.034429587,0.014869401,0.025962755,-0.054220807,-0.05525085,-0.003258298,-0.055713918,0.053535674,0.0063862163,0.0334669,0.009774546,-0.04435225,0.00018804114,-0.022577498,0.049328838,0.057324525,0.07194375,0.05564915,0.025867682,0.08186892,0.05000394,-0.07097252,0.1194381,0.020753188,0.031140989,0.04031132,0.004899122,0.14906998,0.07871672,-0.059856035,0.062793225,-0.13207851,0.0052123494,0.0494082,-0.007192327,0.0025655841,-0.018905101,-0.023087604,0.0065055597,-0.037684992,-0.04996219,-0.0060556442,-0.032779608,0.022259269,0.07142429,-0.015117794,-0.06549164,0.022040093,0.0581689,0.08061892,0.07037121,-0.014238406,0.009699547,0.001969176,0.04043769,-0.0005453228,0.008811805,0.013246614,0.063480794,0.021225402,-0.08669272,-0.035223357,0.009789052,0.037539355,-0.009215917,0.020541446,0.01197658,-0.06343265,-0.03159497,0.03388753,-9.962716e-34,0.12022892,-0.05662359,0.053713717,-0.020614773,-0.020761067,0.057850145,-0.06657684,0.06427753,0.032590695,0.018540861,0.036248114,0.053008,0.030345121,-0.031337656,-0.055339716,-0.08510823,0.036627036,0.11927003,0.015238813,0.05924089,-0.09627025,0.014728609,-0.025027668,-0.010564832,0.063228756,0.019221852,0.025886752,0.034072116,-0.031776004,0.058564674,0.09647766,0.044955872,-0.04197985,-0.06149315,-0.027080307,0.08230455,-0.050478473,-0.037216805,-0.023340464,0.071304135,0.042587798,-0.0448319,0.014905459,-0.0041500884,0.06800507,0.022967478,0.005226546,0.042272706,-0.08279181,-0.0944539,0.020441279,0.033474546,0.0047655264,-0.04491994,0.11558707,-0.0073417285,0.006897716,-0.037006423,0.045126952,-0.06135943,0.008767429,-0.007915775,0.0048563723,-0.01593932,-0.07959664,0.04583321,0.0068394206,0.022682061,0.052512497,0.038207304,0.015648203,0.01589127,-0.028656373,0.028661875,-0.04444337,-0.027214913,-0.03851014,-0.020183323,0.011026259,0.010879235,-0.042353146,0.07142441,0.024979847,-0.09720185,-0.0239791,0.05164661,-0.021406528,0.0958959,0.0078119957,-0.00538138,-0.024977617,-0.044893906,-0.00918503,0.031237101,0.03972353,-2.0262148e-08,0.031762365,0.02493544,0.10654801,-0.058890827,0.0195598,0.009323773,-0.018347498,0.028006904,-0.023644373,-0.066792704,-0.044447802,0.0029314596,-0.012770993,0.053227477,0.016294532,0.012121745,0.016632201,0.028019888,0.012344886,0.029100163,-0.11127985,0.04194095,-0.05275338,-0.008363292,0.018511174,-0.010708999,-0.0044413377,-0.111258745,0.01465458,-0.022312216,0.116699405,0.008914349,0.092354394,-0.07213371,-0.056168932,-0.040095557,0.021476615,-0.08735116,0.03936791,-0.057776034,-0.0493168,-0.0018425254,-0.048692092,0.009128702,-0.016947515,-0.021882115,-0.010004807,0.038413383,-0.023654453,-0.021886457,0.040292997,-0.023216166,-0.009619322,-0.103841215,-0.030079903,-0.07794922,0.016227748,-0.10198624,-0.009515544,-0.10409651,-0.06001148,0.02621721,0.11276822,-0.008922363 +2.1.1.113,"This is a large group of enzymes, most of which, with enzymes of similar site specificity listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease), form so-called 'restriction-modification systems'. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html.",384,1.0,-0.051357526,-0.048472144,-0.060762968,-0.06974141,0.085943855,-0.015569775,-0.055193514,0.0012060641,-0.031167055,-0.04727895,0.030128913,-0.05129396,-0.03945309,0.013093222,-0.08015921,0.052748628,-0.040359177,0.013645751,0.0043231393,-0.07098157,0.057075232,0.05908189,0.00013508505,0.011183234,0.01699822,-0.021138554,-0.00063749956,0.008031313,-0.03321647,-0.109292954,0.04369444,-0.026778936,0.046639718,-0.05450356,0.09798516,0.06757204,-0.092073634,-0.046008613,0.024755776,0.06328571,0.011507825,0.01725455,0.0016170002,0.009762189,-0.04927279,-0.02533547,-0.047658395,-0.016790006,-0.016907683,-0.008978567,0.018641964,-0.082080625,-0.057764124,0.07814309,0.039479904,-0.008199252,-0.033891447,0.01617552,-0.03999529,0.008539164,0.07470087,-0.02164327,0.04040496,-0.069910035,-0.010036265,0.075909115,0.0081235515,-0.044606876,0.04793179,-0.12154657,-0.030022578,-0.07308744,-0.06209078,0.0648249,0.025520021,0.051389873,0.0023669382,-0.010714863,0.008018284,-0.049360763,-0.003807519,-0.048026573,0.042136226,0.057352357,0.038033623,-0.034171935,0.018961828,0.01254971,0.06549923,0.07507575,0.021939682,-0.042191606,0.03545399,-0.025921114,-0.028338868,0.061512288,-0.020830974,0.07605416,0.03424963,-0.016168095,-0.009295482,0.026835766,-0.010841747,-0.04198366,-0.072895534,0.0030982154,0.011292957,0.101028584,0.033032533,-0.025591627,-0.018094027,0.03867952,0.043952137,-0.050845362,-0.06781842,0.07114818,0.05372073,-0.04658505,0.033238847,0.020052457,0.07923278,0.010700898,0.120779224,-0.018605763,0.017474104,0.06783495,-0.18337902,4.80239e-33,0.050142754,0.07420656,-0.0060175,0.015557468,0.0014040918,0.0053504496,-0.08378152,0.063902184,-0.1069957,-0.03236917,-0.047902603,-0.016057132,0.058113296,-0.020621799,-0.029471792,-0.06382259,0.0002828108,-0.013761482,-0.0067106294,0.014354631,-0.02528677,0.0455441,-0.07966032,0.07608067,-0.016352622,0.038567774,-0.062070485,0.056310903,0.05928092,-0.00419145,0.03652619,-0.10640456,-0.0663385,0.028027713,0.019454923,0.039410133,-0.005936258,-0.040053792,0.0013861426,0.037252825,0.03864485,0.02981456,-0.004976374,-0.0615201,0.091189414,-0.05214941,-0.06408026,0.07221378,0.022330593,0.008836355,0.0060456786,-0.0175585,0.08670427,-0.03353025,-0.026661402,-0.041326314,-0.104183115,0.05711812,0.08167617,0.06652742,0.045803115,0.071187675,-0.038828224,0.01944171,0.022217559,0.009719482,-0.04802869,-0.052402627,0.018146403,0.064440034,-0.05842163,0.016345479,0.07159122,0.023117254,-0.010498625,-0.056543406,-0.052336704,0.047896978,-0.013277948,-0.01805641,-0.026572289,-0.0034102777,0.03653462,-0.010289765,-0.018037403,-0.09119989,-0.08482728,-0.023382708,-0.04327487,0.019433876,0.045959063,-0.031537507,-0.08870502,0.008009313,-0.006911691,-4.1260046e-33,0.015826058,-0.05684549,0.006764498,-0.11331339,-0.028515449,0.06288283,0.043078255,0.019385485,0.0627245,-0.035257347,0.08718336,-0.019422282,0.04004104,-0.102968365,-0.05088306,0.00740375,-0.088815756,0.016818453,0.008955532,0.001480417,-0.030126257,0.09458538,-0.042680383,0.0663948,0.010281228,0.0569195,-0.030958822,0.080683015,0.09883875,-2.0517262e-05,-0.10881138,0.01195525,-0.0072957515,0.07055673,-0.04615963,0.011805659,-0.07594017,0.039679877,0.031636838,-0.014931071,0.01266091,0.03971997,-0.040310435,0.061143145,-0.008486377,0.11568922,-0.07874004,0.059883066,0.03992432,-0.024146713,-0.0288132,-0.048190504,-0.01396993,-0.04844913,0.017884003,0.038984016,0.025283888,-0.007150959,-0.0074431715,0.027706644,0.03030231,-0.02003711,0.00020403275,0.04864725,0.018285077,0.050245877,-0.03883057,0.04972954,-0.027642615,-0.0061671645,0.06708268,-0.00994588,0.008450724,-0.059149552,-0.021157816,-0.075800434,-0.06988825,0.03472587,-0.023866272,-0.06286345,0.0016433656,0.014364431,0.033625133,-0.012979176,0.10462246,-0.01626523,-0.04878885,0.09723733,-0.0060696667,-0.0010057673,-0.08670295,-0.022762325,-0.13619848,0.10684197,0.06994657,-4.8891152e-08,0.11585429,-0.05426086,0.039261743,-0.0047655017,0.13080268,0.0574799,0.032828167,0.03518848,-0.0062387106,0.03649786,-0.01832017,0.074881025,-0.01928161,-0.00066136185,0.07755354,0.00856128,-0.040502504,0.057415724,-0.026914908,-0.0028262415,-0.025644112,-0.006349728,-0.039927464,-0.0017162581,0.029031383,-0.07252994,0.039222136,0.052208185,-0.01109921,-0.032113012,0.0023970213,-0.004554554,0.04170487,-0.02140077,-0.058269568,0.022793474,-0.08676093,-0.00083251554,-0.06270704,0.035201006,-0.035248205,-0.07293176,-0.039618038,0.016779039,0.005077121,-0.046746243,-0.023809556,0.00886766,0.033060335,-0.00030373572,0.051409453,-0.023482753,0.05179227,-0.0016367873,-0.107321806,0.10654286,-0.02138442,-0.045781504,0.02347491,-0.033514854,0.06458265,-0.008643642,0.17316955,-0.00016367734 +2.1.1.114,"This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast [3]. The enzymes from yeast and rat also catalyse the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively [2] (this activity is classified as EC 2.1.1.64, 3-demethylubiquinol 3-O-methyltransferase). ",384,1.0,-0.046100684,-0.005168589,-0.11903133,-0.063818164,-0.022744467,0.069815725,-0.03727521,-0.0291849,0.044560265,-0.05765971,0.02573893,-0.031597752,-0.036635935,-0.027554786,-0.01782337,0.04524279,-0.07520498,0.007640822,-0.064562865,-0.06484222,0.06717852,0.04007728,0.004647375,0.023816286,0.04479424,-0.07828702,0.064996876,0.010576327,0.009922621,-0.06820582,0.04269751,-0.0060422933,0.055520397,-0.08969359,-0.011509977,0.082063764,-0.046511725,-0.08415089,0.028470846,0.08417703,0.030315315,-0.05832825,-0.05545488,0.08433017,0.024826834,0.030727236,-0.054483768,0.03224071,0.05236699,0.020101842,-0.0058910004,0.03319447,0.008928269,0.078217685,0.07260534,0.0029213761,-0.059862737,0.065934345,-0.0074241403,-0.003182171,-0.0038889318,0.0330605,0.07640293,-0.0009979929,0.036918197,0.041923117,-0.011721985,-0.081425354,0.033149056,-0.004319228,-0.033336747,-0.06991696,-0.05565245,-0.001407304,-0.077222355,0.11762829,-0.039959922,-0.012681794,-0.012520461,-0.041474797,-0.006369762,-0.0051789773,0.111123934,0.024458395,0.027531153,-0.013565335,0.0020469422,-0.016174275,0.038545076,0.07116301,0.034858245,-0.03151936,-0.017348792,-0.013102761,0.002287904,0.045457747,0.055093277,0.09091968,0.025920566,-0.024157517,0.06624679,0.05133543,-0.054360237,-0.033091273,-0.019434039,0.053712074,0.0758137,0.08750861,0.024066603,0.015570528,-0.056916084,-0.04930596,-0.026065059,-0.0022973248,0.016329264,0.04423633,0.115725614,-0.011464012,-0.003149067,-0.03613664,0.03467694,0.04267972,0.09155762,-0.010563243,-0.029942797,-0.005845782,-0.08481657,3.3611263e-33,0.06909415,0.036312252,-0.021712048,-0.0036019303,-0.03969958,0.0005973446,-0.09017116,0.047234662,-0.09394974,-0.047323618,0.012370042,0.006818555,0.04394255,0.06549311,-0.018572241,0.021163806,0.004984579,-0.07464925,0.029601278,-0.018684786,-0.03326808,-0.010116115,-0.08478039,0.0050168927,-0.018096682,0.013374266,-0.034296684,0.063297674,-0.06648213,-0.011784349,-0.06495637,-0.050139323,-0.06020884,0.0070547406,-0.06381113,0.041107774,-0.09546227,-0.007100039,-0.029209089,0.027991826,0.05571881,-0.0008168021,-0.0050297827,-0.047667902,0.06896483,-0.004485084,-0.02423913,0.047041792,-0.030126024,-0.0255537,0.0068530114,0.087779656,0.09933851,-0.016992787,-0.06938722,-0.008993832,0.03189071,0.07799789,-0.004301798,0.037458397,-0.09468057,0.020990575,-0.001378848,0.09500807,-0.023410438,-0.024944033,-0.030793728,0.011105882,-0.057027306,0.07514947,-0.025929336,-0.07084171,0.014765426,0.015575718,0.03538308,-0.009859983,-0.036430717,-0.042239655,0.037611812,-0.026540475,-0.063857384,-0.043449398,0.0026971467,-0.06105836,-0.0565715,0.016482258,-0.0021800864,-0.045198467,-0.05947449,0.032561664,0.09725463,-0.021499962,-0.016010787,0.042429335,0.024871828,-5.248705e-33,0.059215255,-0.021817075,0.04676422,-0.08818168,-0.03261499,0.09125992,0.10725029,-0.010434403,-0.029344352,-0.061737277,0.094951905,-0.039593454,0.010827777,-0.02741966,0.016681965,0.0073097544,-0.017372636,0.104761265,0.061091453,0.018388202,0.092698365,0.0818726,-0.08760367,0.007274362,0.02141934,0.046664875,-0.0068975883,7.6133714e-05,0.059335437,0.053755913,-0.018969834,-0.042910844,-0.026621118,0.017743584,-0.017032657,0.025416639,-0.031358495,0.024890011,0.015702004,0.021861212,0.008110702,-0.0016060512,-0.059272066,-0.012199189,0.06195588,0.14783177,-0.04911937,0.030791333,-0.058677025,0.014961658,0.056422975,0.0154116275,-0.07729985,0.06214551,-0.0045555406,0.05651922,0.036557578,-0.0698427,0.055970993,-0.001211567,-0.037509274,-0.0008566298,0.03339038,0.016049052,-0.05996591,0.075338766,0.030699907,0.054078866,-0.0100110285,-0.03513734,0.051650435,0.020339174,-0.017521523,-0.0015406149,-0.059579883,-0.017574081,-0.08455234,-0.06047786,-0.03280879,-0.024894465,-0.006761679,-0.0467279,0.03767335,-0.0072335773,-0.079003096,-0.064667836,0.0761494,0.09364364,-0.02698344,0.07409603,-0.057839405,0.016991517,-0.12166313,0.006172558,0.026262857,-4.281522e-08,0.04431224,-0.06181875,0.046303235,-0.07238013,0.057802454,0.008113509,-0.034330726,0.085491285,0.016860977,0.023010872,-0.05398765,-1.5916063e-05,0.013210693,0.054335505,0.06305122,-0.05451766,0.03210925,0.00092476973,0.013592332,-0.0718761,-0.074515566,0.0585214,-0.037913863,-0.02649446,0.01341458,-0.06441681,0.034690496,0.09543312,0.008833169,-0.06986736,-0.010366058,0.053283315,-0.019353297,-0.035283428,-0.0778419,0.01645643,-0.044633545,-0.10145693,0.024743283,-0.01994584,-0.08083744,-0.08834366,-0.045177173,0.04282616,0.0126475515,-0.06886019,0.027712628,0.0192784,-0.036602948,-0.062176023,0.019931128,-0.046922937,0.022309892,-0.0605925,-0.03997261,0.029662415,-0.071952686,-0.07730178,-0.018481132,-0.1337821,0.0055080475,-0.03694635,0.1602922,-0.13265817 +2.1.1.115,"Broad substrate specificity for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine. Both R- and S-enantiomers are methylated. The enzyme participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants. The physiological substrate is likely to be coclaurine. The enzyme was earlier termed norreticuline N-methyltransferase. However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines.",384,0.99999994,-0.032787174,-0.052414283,-0.076403536,-0.03918388,0.041429736,0.0692151,-0.10535235,0.046954434,0.03126208,-0.111346275,0.013012026,-0.046700377,-0.046645083,0.019482227,-0.021850318,0.028122421,-0.08720226,-0.04353082,0.07924697,-0.051726535,-0.019936463,0.07399033,-0.029032182,0.009040421,0.025830336,-0.059234973,-0.06846633,-0.020679103,0.012944709,0.0023913705,0.03220607,-0.0061672507,-0.03734966,-0.04879547,0.023526015,-0.0012046058,-0.041523714,0.0054027895,0.036176525,0.08170854,0.036974624,-0.0077613564,-0.10107805,0.038378097,-0.039342005,-0.04463059,0.008795978,-0.006735399,-0.0062305504,0.0055363886,-0.009660857,-0.04344289,-0.039260183,0.05413031,0.012961833,-0.027715702,0.031865843,0.09197924,-0.043741688,0.06187394,0.08065289,-0.02661149,0.0016621283,-0.026552703,0.014752595,0.06955204,-0.055303067,-0.0565985,0.09085585,-0.054304305,-0.052374728,-0.074743204,-0.06458143,0.006657926,-0.07590492,0.040903725,-0.039979838,0.04414724,-0.009366944,-0.05266072,0.033748493,0.045339543,-0.06256616,-0.0012635676,0.010355922,0.0037761922,-0.040318172,0.02886505,0.089337744,0.032905117,0.07502949,-0.02775487,-0.039433256,-0.0317312,-0.047501065,0.054786272,0.015197038,-0.0047450303,0.033584327,-0.04412479,0.034607645,0.0064332867,-0.11324197,-0.011193784,-0.0424598,0.11004369,-0.06586706,-0.04993405,-0.043747302,-0.0065496624,-0.04093198,0.013007655,0.05769787,-0.011413798,-0.04964585,0.065664984,-0.008807222,0.016698,0.013523619,0.045739353,-0.005565832,0.020876817,0.050678793,0.0019564677,0.036513302,0.112782665,-0.10349737,4.3151663e-33,0.05925775,0.04095813,0.005561429,0.0003176703,-0.007891001,-0.027697196,-0.05107108,0.065455884,-0.02632031,-0.06529866,-0.050551467,-0.08368653,0.028373858,0.017381618,0.02419836,0.025413834,-0.022748016,-0.008189063,0.029273778,-0.022542246,-0.05151402,0.03732577,-0.08127628,0.0057313973,-0.0370281,0.0022754127,0.008060993,0.010092044,-0.017489018,-0.061539907,-0.026417496,-0.1314915,-0.04867533,-0.0065212515,0.10334584,0.010243865,0.0057699587,0.026349397,0.00060554384,0.05237785,0.044816803,0.0779941,0.017248293,-0.008030005,0.06698516,0.0096881185,-0.102440916,0.12241617,-0.028395055,0.029489884,0.025539748,0.025772292,0.0462722,0.023532478,-0.0010666599,0.025895145,0.0019684243,-0.003090958,0.001442549,-0.025955305,-0.019775635,-0.016848315,0.014874577,-0.026580567,0.062347613,-0.04199785,-0.09985139,0.0026514349,0.0060619395,0.026292693,-0.015946973,-0.022767806,0.06351321,0.048398722,0.06648498,-0.064945,-0.08373301,0.017761428,0.078718,-0.055013478,-0.0033721107,0.051989254,0.05882663,-0.05709675,-0.08379852,-0.01801291,-0.028707981,-0.06356678,-0.030741796,0.034918778,0.03981599,0.015701173,-0.051011235,-0.004954943,-0.018891847,-4.6053973e-33,0.06313268,-0.06970965,0.03917588,-0.095698915,-0.011718593,0.045706037,-0.036257785,0.01534705,0.03083066,0.015407233,0.079325184,0.03205048,0.024272626,-0.03105511,0.045974966,-0.038865592,-0.024942745,0.17309155,0.04998558,-0.02522622,-0.041407786,-0.009119762,-0.06531001,0.067329966,-0.008333004,0.042701244,0.0006142513,0.009324939,0.022657957,0.11093751,-0.01600752,0.0009409399,-0.008217431,0.002177043,0.047785584,0.075448625,-0.006214908,0.001415152,-0.010883368,0.04690829,-0.02864658,0.08694185,0.034319162,-0.024846897,0.031033825,-0.034153186,-0.07478046,0.01738783,-0.063208096,-0.00053036585,0.06039639,-0.007948927,-0.016534897,0.009337267,0.041836075,0.03809098,0.01075915,-0.029752903,0.06452159,-0.048918918,0.060173124,-0.0519276,-0.06708475,-0.020803316,0.02315164,0.037350647,0.047071297,0.055148527,0.037920192,-0.0231359,0.0070094015,0.0072287805,0.052966982,0.04005172,-0.068218194,-0.022679787,-0.01925207,-0.08675107,-0.019699806,-0.054696593,-0.018856736,0.0013333594,0.036835898,-0.05168146,0.014369989,0.0064416807,-0.0014228269,0.11015955,0.059065413,0.06297827,-0.007862388,-0.015787737,-0.06864257,0.08688113,0.08146019,-4.6654634e-08,0.1271576,-0.08971405,0.0079468675,-0.042618524,-0.03350772,-0.0013057302,0.024884539,-0.047044303,0.026900206,-0.04034617,0.021389304,0.009601852,-0.047527757,0.08909971,0.058483563,-0.034252837,0.033064276,0.06987471,-0.060044073,0.0218409,-0.06549439,0.05938231,-0.08655574,-0.0655788,0.021711748,-0.06645299,0.020527128,0.13624464,0.108813986,-0.028881086,0.015078425,0.026630193,0.03941375,-0.07271611,-0.04994284,0.034698304,0.02183385,-0.012168123,0.03834359,-0.0076532722,-0.06525142,-0.05580946,-0.051751725,0.022297874,0.06908861,-0.08075638,0.009343969,0.037670683,0.0033097747,0.028147867,-0.0031892979,-0.007838788,0.05716078,-0.12454305,-0.114346944,-0.0016118503,-0.07762303,0.029038116,-0.037625458,-0.14493118,-0.05337664,0.0020337282,0.1891187,-0.014272122 +2.1.1.116,"Involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (RS)-laudanosoline, (S)-3'-hydroxycoclaurine and (RS)-7-O-methylnorlaudanosoline.",384,0.99999994,-0.02928574,-0.0074045723,-0.051021587,0.024115713,-0.012030901,0.065217614,-0.06286882,-0.015369468,0.06997272,-0.033863578,0.039959617,-0.013332632,-0.022952197,-0.07089173,-0.019683888,0.104020454,-0.10139367,0.09609774,-0.04222572,-0.044804357,-0.011636767,0.03369939,0.022190696,0.032843065,0.05774283,-0.027034216,-0.055376973,0.025073374,-0.020216662,-0.012144959,0.011372775,-0.0039955364,0.03178386,-0.06082859,-0.040029045,0.032322,0.014230919,-0.028498283,0.056832895,0.08303422,0.007422437,-0.040399894,-0.09243171,0.0077806944,-0.07149095,-0.04810364,-0.018240172,0.0058577307,0.039380472,-0.027668482,-0.04302923,-0.052497007,-0.07692963,0.06255497,-0.050482217,-0.037943162,0.048860975,0.11816164,-0.04657483,0.019623933,0.014044589,0.0074130623,-0.02038244,-0.011940092,-0.007958673,0.013221962,-0.05019326,-0.018286608,0.116761014,-0.041095793,0.011910624,-0.13989158,-0.0368359,-0.0026969572,-0.041853286,0.10008296,-0.03448528,-0.033894397,-0.013065839,-0.09653746,0.03430924,-0.006037054,-0.02456877,0.008106875,-0.018663906,0.009584653,-0.035506085,0.037337758,0.07540941,0.044756867,0.077866,-0.019432312,-0.044849977,-0.048283573,-0.019855376,0.05787875,0.08751864,0.017590284,0.004312767,-0.037257347,0.023310468,0.057207882,-0.124071494,-0.055445295,0.013801792,0.07899163,-0.05217748,-0.03346083,-0.07701836,-0.062683634,0.0071052816,-0.0043609645,0.003474528,0.029757934,-0.008304923,0.049199503,0.058902282,-0.0020050374,-0.094157435,0.016703432,-0.08165497,-0.0036917583,0.05531126,-0.0007203389,-0.022594446,0.004784261,0.01558801,4.943531e-34,0.027540889,0.060608596,-0.0135376025,-0.062728435,-0.00983922,-0.053293366,-0.044569556,0.020461494,-0.041783836,-0.05077401,-0.06945575,-0.064447485,-0.0015361276,-0.0046609705,0.0056530368,0.004357451,-0.007857007,-0.034009874,0.048233658,-0.038169347,-0.036058772,0.021673981,-0.07278721,-0.04001867,-0.058567267,0.030258428,0.04310522,0.02650316,-0.046719536,-0.018561294,0.019614598,-0.12443525,-0.05177813,-0.021716122,0.022567883,0.030661296,-0.038734373,0.020619374,-0.010903734,0.0802048,0.005971964,0.024388265,0.043674644,0.026314383,-0.0062094745,0.057056457,-0.07501829,0.14893164,0.07052808,0.059343215,0.0043014716,0.004170731,0.070693925,0.017959323,-0.024225166,0.0015836685,0.0322663,-0.0605374,-0.0059752096,0.024631437,-0.0018413177,-0.048799317,0.030710518,0.019260496,0.016037416,-0.04728585,-0.0926714,-0.024802156,-0.013027346,0.025547087,-0.045960683,-0.046211615,0.036082864,0.009135034,0.033781577,0.0122063495,-0.05317482,-0.035612356,0.0013751946,-0.010405674,-0.036534775,0.007112409,0.04714596,0.0127986185,-0.049006525,0.02078649,-0.038082838,-0.020708313,-0.029988151,0.018736182,0.06631871,0.02489464,-0.05616948,-0.008972616,0.018185975,-2.1482999e-33,0.10732276,-0.050506838,0.03197472,-0.10206029,-0.043805987,0.046097036,-0.07702963,0.013868043,-0.011270584,0.068188354,0.047216646,0.02874176,-0.0019772146,0.029123899,-0.013165598,-0.056117404,0.042254828,0.13733155,0.03352716,0.03087695,-0.04093733,0.034491073,-0.06333611,0.11524936,-0.0036176445,-0.03946256,0.034526836,-0.02795908,0.021726772,0.08873515,0.07784628,-0.0066056955,0.016174836,0.028857172,0.056883145,0.06262237,-0.0007351121,0.036337823,-0.005364483,0.053709164,-0.013356715,0.014382367,-0.02555762,-0.071928896,0.08373205,0.01429797,-0.061781462,0.04426128,-0.09211192,0.009870582,0.15077357,0.035376552,0.021259064,0.034697745,0.07532503,0.07965285,-0.040146694,-0.0010490807,0.075510226,-0.064748414,0.020976126,-0.04410523,-0.021600263,-0.019016456,-0.01562716,0.08052733,0.02865152,0.019869534,0.02136046,-0.03145117,0.04942358,0.0005830782,0.003291924,0.09677592,-0.06860387,-0.036082454,-0.0075756605,-0.067824714,-0.032964487,-0.014473338,0.018781796,-0.016943997,0.060654517,-0.075601056,-0.07011476,0.0022646363,-0.017936068,0.109979115,0.011606457,0.04402875,0.016337173,-0.008296528,-0.101004705,0.03791031,0.12144273,-3.4299696e-08,0.033354394,-0.075939104,0.056222778,0.036759686,-0.04165364,0.01618058,0.0039514406,0.004145743,0.031941175,0.01743624,0.00828308,0.023674883,-0.030200707,0.06457423,0.0041883145,-0.012355616,0.0813352,0.06382077,-0.012750273,-0.017366534,-0.08956663,0.06094142,-0.02994079,-0.0794562,0.06501798,-0.08432323,0.013519401,0.12612057,0.07997981,-0.035507865,0.11285856,-0.0031961144,-0.014232632,-0.06491884,-0.053815626,0.005288612,-0.020003438,-0.06650495,0.03799859,0.013575612,-0.07089411,-0.004440309,-0.03723595,0.01222188,0.035530627,-0.044765536,0.004206395,0.031248912,-0.0041189212,0.0077849645,0.04086711,-0.04392864,0.08712946,-0.14686126,-0.09191363,0.018763943,-0.042595826,-0.026114449,-0.071965,-0.112163454,0.014276781,-0.002531254,0.14771849,-0.075143635 +2.1.1.117,The product of this reaction is a precursor for protoberberine alkaloids in plants,384,1.0,-0.034823317,0.008654626,-0.08966976,-0.050536674,0.049487136,0.122321896,-0.023689926,0.044837967,0.10191073,0.07184453,0.027915914,-0.07345211,-0.014258331,-0.057487775,-0.06923266,0.06756849,-0.009259638,0.042773828,-0.018950883,-0.009060399,-0.012183451,0.082536645,-0.010131252,-0.025796652,0.056932643,0.0077829394,-0.02285452,-0.050881576,0.030706737,0.03387101,0.053882606,-0.034365296,0.004750418,0.009731856,0.006633732,0.021554789,-0.05060397,-0.0059127877,0.044726476,0.087528035,0.027525766,0.0022632368,-0.0867507,0.010675842,-0.057952274,-0.025511676,0.009880987,0.059446447,0.0077947024,-0.036187273,0.0139641315,-0.036972474,-0.030556278,0.04490167,-0.009794451,-0.06321847,-0.013026725,0.07215036,0.032599337,0.04243706,0.081312045,0.031096924,-0.022142032,-0.05130418,0.04453105,-0.026755728,-0.018641386,-0.017324636,0.07403882,-0.078378476,-0.006497928,-0.038723703,0.05741445,0.028315071,-0.027951712,0.052312206,-0.01817582,5.130458e-05,-0.03838774,-0.03372126,0.068558335,0.024262125,-0.034266472,0.030635597,-0.02359958,0.029927142,0.032730922,0.09172234,0.023142474,-0.036953732,0.04286728,0.0052769687,-0.07239252,0.03563717,-0.16919205,0.055759896,0.07099316,-0.04536994,0.062569976,-0.07688898,-0.016361922,-0.015421234,-0.06670342,-0.0907901,-0.041615553,0.028091682,-0.030822275,0.026167858,-0.05937922,0.055209544,0.067324944,-0.06689678,-0.059366778,0.04511915,-0.015421866,0.07949921,-0.0055564884,-0.09086713,-0.006179945,-0.02945607,0.0010098601,-0.0042704963,0.06695203,0.09699061,-0.05731059,0.022743978,-0.040174656,-3.2315453e-33,0.048748642,0.07882416,-0.06865125,0.071669474,0.04556483,-0.035759177,-0.058895163,-0.05260071,-0.0066055334,-0.07925432,-0.08256403,-0.028516326,0.03795747,-0.04093227,-0.0013593938,0.009361829,-0.100869775,-0.04746071,0.08825696,0.009405762,-0.025262821,-0.009760977,-0.086302176,0.044246368,-0.043490823,0.013826353,0.041057527,-0.013235818,-0.0054624667,-0.06172025,0.015183864,-0.09275233,-0.023332024,-0.0017058994,0.021070834,0.0035495695,0.007452913,-0.018400839,-0.013107444,0.054745127,-0.01215936,0.024064524,0.032233726,0.026006171,0.121693835,-0.06434088,-0.07785357,0.024477508,0.056467097,0.023617817,0.027677864,0.00044656763,0.10152559,0.025672123,-0.10809129,0.054032702,-0.037571818,-0.0069863847,0.06842855,0.049477447,-0.07985317,0.03349151,0.0033048373,0.026408156,-0.0025378955,-0.026378578,-0.019829743,-0.03699533,0.012789712,0.04835107,-0.038090583,-0.056723677,0.111391515,0.04187804,0.021056201,0.04452588,0.009792945,0.06572483,-0.045276724,0.0074992618,0.039378975,-0.014735349,-0.013118412,0.058636066,-0.07747728,-0.07056064,-0.055111535,0.000324752,-0.025374668,0.073992945,0.0148600545,0.021676531,-0.05104524,0.0030943803,-0.010604518,2.1186982e-33,0.15523921,-0.048355144,0.020103788,-0.02178125,0.00050925993,0.058308993,-0.045450952,-0.03888729,-0.033884913,0.0065233023,0.05189579,0.0049087284,0.066545196,0.01914146,-0.0890406,-0.08159929,0.07407079,0.080050856,-0.018875645,-0.012217706,-0.02271239,0.057582982,-0.074790195,0.013176061,0.051528264,-0.041889485,0.06803145,0.041321866,-0.06712987,0.019885754,0.13566703,-0.011389174,-0.03665107,0.009607279,-0.009940598,0.08528819,0.0008235136,-0.0066239797,0.034411408,0.056400288,0.0038508698,-0.050284818,0.0014896829,0.0071801813,0.03097803,-0.021582462,-0.020820417,-0.02768994,-0.018816385,0.0035368695,0.028878814,0.02900867,-0.04594022,-0.066727474,0.03265175,0.03753522,0.056190964,-0.029563235,0.034670386,0.037968315,0.082514,-0.035910286,0.07847893,-0.06819628,0.0038182542,0.05234872,-0.05384938,0.1319496,0.1049976,0.013314837,0.083629645,0.054788094,-0.0006204238,0.093114,-0.002266637,-0.09420829,0.02599061,-0.042102437,0.04818208,-0.027954524,-0.06070562,0.030281952,0.06852838,-0.069964536,-0.027359948,0.016952535,-0.020431006,0.13634434,-0.027701646,-0.0037517159,0.0008824011,-0.054593273,-0.08097597,0.0528823,0.062716275,-1.9992438e-08,-0.03385747,-0.009366441,0.030592311,0.003982757,-0.041329812,0.0004027526,0.07517783,-0.04824472,0.0073991935,-0.109650046,-0.052327514,-0.0012387615,-0.009938297,0.055585604,0.039809976,-0.008011417,0.010695728,-0.044342015,-0.06964982,0.0055277706,-0.052143898,0.053188164,-0.07411291,-0.05489264,-0.0060269157,-0.058174305,0.043999407,0.045455474,0.025160851,-0.005398128,-0.0019388495,-0.003911792,-0.023352824,-0.0407636,0.022614053,0.04774863,0.019822253,0.045750763,-0.02573002,-0.042715583,-0.056158837,-0.023130238,-0.053623434,-0.0037340974,-0.04163599,0.030860158,-0.039900582,0.0252343,-0.020753846,0.015861845,0.06637107,-0.030813433,0.021655664,-0.08796406,-0.13294949,-0.0050545456,-0.03929372,-0.061265703,-0.0032198457,-0.11918708,0.02364293,-0.012546873,0.13219146,0.049032874 +2.1.1.118,"The product of this reaction is a protoberberine alkaloid that is widely distributed in the plant kingdom. This enzyme is distinct in specificity from EC 2.1.1.88, 8-hydroxyquercetin 8-O-methyltransferase.",384,1.0,-0.04318542,0.051408608,-0.07122664,0.0028745758,0.059393898,0.06658273,-0.025311654,0.072805144,0.09993415,-0.052464914,0.047258753,-0.105199516,-0.06004902,-0.080343276,-0.09116831,0.070380315,-0.046275806,0.0007207314,-0.06816622,-0.055413086,0.024198202,0.062233407,0.05955588,0.023620296,0.0019809145,-0.013439786,-0.017649777,-0.0076437,0.008967961,-0.086216085,0.08677517,-0.0088811265,-0.008250156,0.008877423,0.008292469,0.043116726,-0.03060308,-0.062681764,0.006708687,0.07882198,0.076575845,-0.04591888,-0.08496397,-0.054778945,-0.029144935,-0.057296142,0.019492289,0.001980938,0.031832404,-0.008375015,0.01611667,-0.057109673,-0.03502672,0.034023277,0.038212813,-0.031720668,-0.012383386,0.015222665,0.02598542,0.06526182,0.08849518,0.038973156,-0.004744432,0.0070039164,0.002706852,-0.05814747,0.03300457,-0.06592419,0.047145497,-0.102165855,-0.03741767,-0.07705734,0.033330407,0.05851825,0.020631468,0.058834855,-0.033441503,-0.028286869,0.03335381,-0.022734856,0.051197633,-0.0206013,-0.07407765,0.01770794,-0.025995357,-0.036558583,0.009016058,0.059328586,0.082528904,0.031056624,0.016759569,0.0029530942,0.004207411,-0.00073408516,-0.11639799,0.075427406,0.09049641,-0.0069971257,0.038607687,-0.0019983964,-0.018978167,-0.0021849023,-0.06952753,-0.07982127,-0.055769645,-0.013129628,-0.0111162495,0.046401702,0.029526567,-0.034884855,0.027598724,-0.086859226,-0.025223985,0.030246912,-0.001620283,0.07302672,-0.013019645,-0.072255224,0.0058524855,-0.03153816,-0.011599222,0.0050113257,0.035607085,0.07970766,-0.030311767,0.05301152,-0.09032267,-1.5811425e-34,0.08698201,0.05823809,-0.00967417,0.017344642,0.018571587,-0.035119228,-0.07094008,0.02243046,-0.041088484,-0.116541184,-0.10715367,-0.040993482,-0.011144381,0.009756368,-0.0076649236,-0.031719346,-0.03530543,-0.046092425,0.07107446,0.0005577313,-0.00027289256,0.0009379298,-0.10579297,0.033799455,-0.018274264,0.015567671,0.045600053,0.012507283,0.04471871,-0.022302456,-0.018908676,-0.10359514,-0.038204107,-0.0075126067,0.0035573523,-0.027102452,0.03334219,-0.036480054,0.015967641,0.069000535,0.016376128,0.031034088,0.07290571,-0.019078303,0.09355629,-0.053293947,-0.08269994,0.049757287,0.11537902,0.039147917,0.005827966,-0.0081847245,0.14388603,0.01988188,-0.045168474,0.047180936,-0.06533197,0.03568633,0.050710097,0.05431816,-0.03760979,0.06290898,-0.015737068,0.025474349,-0.028309263,-0.006434064,-0.063851796,-0.02932849,-2.689292e-05,0.020487897,-0.04671917,0.010513168,0.11968258,-0.0018780065,0.08305056,-0.0050166845,-0.069944546,0.07391151,-0.027096799,0.07795184,-0.03367124,0.021898266,-0.019986315,0.03996625,-0.039903242,-0.00485161,-0.017312016,0.0053825257,-0.020739133,0.119193874,-0.0032776832,-0.037954252,-0.03911506,-0.020302298,0.03071423,-8.546999e-34,0.051250014,-0.03143214,0.03506749,-0.043734018,0.030841604,0.046878286,-0.042299904,0.012004478,-0.039894473,0.0057823826,0.035375133,0.0041307965,0.13846856,-0.046802256,-0.022640558,-0.09592463,0.006616148,0.14254929,0.025016434,0.030425008,-0.025026925,-0.004319714,-0.047419522,0.054196,0.08875259,-0.055043463,0.045014743,0.0494236,-0.003430419,0.022039635,0.038690288,-0.017018786,-0.04081828,0.02578453,-0.027150089,0.05150541,-0.018477935,-0.04836491,-0.009195737,0.023043158,-0.018103959,-0.09321721,-0.028638275,0.04759004,0.036034748,0.10511181,-0.02492471,0.022792207,-0.00019014649,0.024189252,0.026062366,0.063055374,-0.047531817,-0.006608627,0.009634584,0.019080866,0.023561928,0.032570355,0.021071656,0.00599431,0.059474714,-0.019148776,0.055756923,-0.02555797,0.011886684,0.109952256,-0.04164612,0.09788923,0.029195763,0.0021224138,0.14833765,-0.02402794,-0.03555193,0.06480965,0.014307513,-0.048109546,-0.016672472,-0.044328578,0.013490728,-0.03483825,0.0018955019,-0.03829099,0.077159,-0.10686881,-0.0026875413,-0.027857987,0.015237707,0.08588311,-0.05317841,0.055680294,-0.0045810873,-0.04427693,-0.1589399,0.02269185,0.04062691,-3.4952492e-08,-0.027944004,-0.082160816,0.07698543,-0.058722958,0.022230938,0.0045365235,0.04159246,-0.01891781,0.010495922,-0.045217868,-0.015305844,0.025097575,-0.015744718,0.04871994,0.023642967,-0.025403233,0.03150383,0.058612548,-0.013957704,0.0032803644,-0.064225785,0.010461068,-0.047389142,-0.042947482,-0.03670305,-0.066940166,-0.013477383,0.10263373,0.035255007,-0.09695153,0.068552256,0.0242042,-0.020883713,-0.003925643,-0.055770647,0.017789418,-0.03262792,0.028257154,-0.018451586,0.013759935,-0.0262406,-0.049281627,-0.05555507,-9.378402e-05,-0.01566818,0.010934623,-0.003971685,0.03883263,-0.0012672533,-0.0084422715,0.060211465,-0.06993433,0.009419201,-0.09839004,-0.10575063,-0.049601734,0.00032723253,-0.09714297,0.005188852,-0.06324368,0.043917235,-0.02000962,0.17111173,0.013662792 +2.1.1.119,This reaction is part of the pathway for synthesis of benzophenanthridine alkaloids in plants.,384,1.0,-0.05915669,0.053137314,-0.063358985,0.000385128,0.015735757,0.12312556,-0.041047335,0.01623446,0.084290154,0.019288652,0.033445515,-0.059702426,0.011617625,-0.07316155,-0.1356146,0.07291687,-0.10966987,0.037806083,-0.07760892,-0.02873953,-0.059981585,0.10437279,0.036100395,-0.03332018,0.036610357,-0.013442661,-0.012504918,-0.013797873,0.017091755,0.025167275,0.049428098,0.027117342,-0.04211482,-0.008075251,-0.012835128,3.622491e-05,-0.059234306,-0.06636957,0.08585964,0.09747562,0.004650309,0.005100081,-0.1131832,-0.020669099,-0.037352722,0.024756087,0.02345762,0.021377463,0.015934298,-0.03086052,0.022661109,-0.012550405,-0.023315625,0.04110823,-0.057518363,-0.013261072,-0.053410385,0.09538441,-0.044341397,0.05460358,0.061913177,0.02734095,-0.017547185,-0.007587108,0.0020256236,-0.02882714,-0.023581756,-0.04682138,0.033390906,-0.07231466,-0.065340616,-0.08951842,0.01793545,0.019166982,0.0035640527,-0.002081698,-0.0070677437,0.0170387,-0.0076197195,-0.07699482,0.047355127,0.000875503,-0.03917224,0.091996856,-0.0018855323,0.04739993,0.001635125,0.05610431,0.088555604,0.014342818,0.064306594,-0.063366964,-0.047152735,-0.04558808,-0.0938885,0.113369904,0.048441216,-0.017446157,0.018516483,-0.005167859,-0.013917118,0.005154706,-0.054660022,-0.115400985,-0.080650225,0.033037506,-0.024882106,0.028627345,-0.09940253,-0.033908207,0.02411258,-0.04494162,-0.012500202,-0.020779563,0.0066198306,0.08851146,0.011601799,-0.08236089,-0.06445799,-0.008005433,-0.0095725395,-0.014558884,0.014675425,0.076031126,-0.045461018,0.018086918,-0.079806454,-1.0977022e-33,0.051317576,0.072069936,0.013709251,-0.0256533,0.06665504,-0.023184517,-0.05308921,-0.019532857,-0.039992128,-0.07025302,-0.09409768,-0.074237466,0.03778339,-0.04052782,0.032984946,0.0014225309,-0.04879791,0.039325695,0.04988614,-0.087787606,0.01472658,-0.019977102,-0.03698095,-0.021510169,-0.020155873,0.08856883,0.020479469,-0.0034564212,-0.0035610776,-0.05303413,-0.0553327,-0.007471699,-0.05289052,0.011318996,0.0044386145,0.028766226,-0.05069129,-0.0231134,0.011131994,0.060485013,0.03603446,0.018276285,0.021724496,0.008637045,0.05039737,0.06422318,-0.089005984,-0.006539123,0.09708354,0.042414233,0.027982853,-0.013148798,0.1035882,0.06480037,-0.059498053,0.08412738,-0.0102996295,-0.040555447,0.021261798,0.027848447,-0.061281007,0.027984492,-0.030727925,0.025666833,0.025749613,0.01873394,-0.097873695,0.0063159657,-0.043927267,0.03977554,-0.0336192,-0.056197215,0.078757666,0.09073462,0.014990517,-0.004933794,-0.053385932,0.04003116,-0.021087157,0.02646311,0.009983731,-0.08569293,-0.014740104,0.033491813,-0.0036151938,-0.011620892,0.008541671,-0.055533726,0.0045262016,0.07568975,0.010742742,-0.008058508,-0.025608385,-0.014601481,-0.0012760913,-1.2324198e-33,0.107512005,-0.0070318407,-0.0008670118,-0.066497125,-0.003107214,0.025129655,-0.082137585,-0.042698413,0.0051086457,0.07936482,-0.010124888,-0.007296689,0.013819507,0.0067351945,-0.074159406,-0.10677757,0.11829456,0.12664868,3.460694e-05,-0.001041425,-0.04530607,-0.009340394,-0.034256585,0.007133526,0.027486578,-0.043968543,0.07845966,0.026533978,-0.027748195,0.06870598,0.020261416,-0.008648962,-0.07421797,-0.026929274,0.07126029,0.09737909,-0.013875173,0.01920087,0.011392966,0.03711273,-0.029772155,-0.0795486,0.009004602,0.086543575,0.079847224,0.011141529,-0.07761265,0.003250809,-0.08848335,-0.083890095,0.06571714,0.079005614,0.012442149,0.023602342,0.073185846,0.059552785,0.053336002,-0.07883981,0.06740427,-0.04827451,-0.0072605023,-0.010349142,-0.029349219,-0.059869774,0.007503446,0.04638545,-0.02074659,0.095430255,0.027800588,-0.008927668,0.035970114,-0.014607652,0.09155289,0.11246787,-0.09962751,-0.07560351,0.049829915,-0.05504937,0.044212732,-0.03197282,0.00799444,-0.013446277,0.07218109,-0.03263696,-0.08785221,-0.046152692,-0.039365362,0.122511744,0.013486271,-0.05834436,0.0040068617,0.03029357,-0.019942619,0.06604198,0.037754524,-2.2351855e-08,-0.011009697,-0.07365003,-0.01060545,0.0005876811,-0.0387592,-0.013233504,0.05547719,0.009144045,-0.00011557044,-0.110150725,-0.04763362,0.05103611,0.017002756,0.08888703,0.010075491,-0.014030051,-0.020718439,0.023277504,-0.0006458411,0.05482748,-0.07706611,0.012482655,-0.06837981,-0.043493286,0.04100207,-0.062799044,0.028079523,0.029582882,0.02552002,-0.032923326,0.06307962,-0.008434379,0.016673144,0.054908015,0.0069233566,0.004463035,-0.023423843,-0.01967872,0.019903505,-0.06931354,-0.0009671902,0.055199295,-0.01523861,0.019726394,0.025963722,0.0070095947,-0.022021519,0.034672596,0.04854476,0.018097173,0.02884189,0.014472345,0.044620484,-0.11747491,-0.080299035,-0.05089613,-0.02722155,-0.054501265,0.0055003418,-0.0720558,-0.024684353,0.035390574,0.11889041,0.05536872 +2.1.1.120,This reaction is part of the pathway for synthesis of benzophenanthridine alkaloid macarpine in plants.,384,1.0,-0.05997521,0.04642393,-0.053013477,0.027620044,-0.0036654256,0.092123605,-0.048166156,0.021554638,0.08797423,0.015076826,0.029779702,-0.07490942,0.012542674,-0.07161214,-0.08397818,0.07874484,-0.12174934,0.026525453,-0.025441695,0.0144660985,-0.03837801,0.0927946,0.03660201,-0.01933895,0.021899434,0.033615865,0.016033841,-0.013899444,0.017645165,0.025957834,0.01452,0.05159101,-0.030107208,0.019604076,0.014707094,-0.006300103,-0.038462322,-0.05510289,0.02227687,0.08285152,0.0032153728,0.021593465,-0.06527231,0.014364489,0.0051169866,-0.020012205,0.0155114895,0.017874446,0.035525456,-0.017100027,0.007700405,-0.06639863,-0.023509594,0.034070127,-0.017300492,-0.022597138,-0.084093705,0.060770214,0.009580749,0.07704633,0.07647281,0.04936565,-0.02188493,-0.026049478,0.018274654,-0.0415821,-0.01745883,-0.03177677,0.069959864,-0.06141031,-0.04773319,-0.10891607,0.041347634,0.0098322,-0.03746949,-0.0076234327,0.031626213,0.0039801463,-0.029520236,-0.071713425,0.024418617,-0.00669859,-0.028928548,0.0746477,0.03313958,0.038270365,0.004118648,0.044269964,0.07401438,0.05261085,0.059650894,-0.028619973,-0.069549195,-0.06660279,-0.068507515,0.07348057,0.054344367,-0.004085686,-0.0010651938,0.027456904,0.007259979,0.019780086,-0.026806919,-0.10428321,-0.06355574,0.020559143,-0.002600687,-0.008884313,-0.090073526,-0.0048984326,-0.019381482,-0.042150605,-0.05331015,0.03948433,0.029641503,0.09289158,-0.0024888122,-0.053749222,-0.049420364,0.007003905,0.0029623457,0.012597672,-0.019222653,0.048849046,-0.026056895,0.01556985,-0.059948485,-1.7022814e-35,0.03871931,0.03080749,0.019302998,-0.04067965,0.097399324,-0.078794904,-0.029237097,-0.01223357,-0.045578204,-0.056711346,-0.10148295,-0.065736584,0.016209787,0.0022860845,0.048557367,-0.039084416,-0.061039675,0.02260929,0.07222964,-0.10512904,0.023908641,-0.0038188105,-0.036815096,-0.014984287,-0.072127916,0.048508674,0.007341439,-0.025343794,0.014591636,-0.040919203,-0.06968684,-0.013690602,-0.043961477,-0.0047083246,-0.016060974,0.01781161,-0.015967077,-0.033270936,0.0010375822,0.05034709,0.019617967,0.0031935808,0.010595348,0.0028090593,0.04129085,0.017130217,-0.12483725,-0.02125356,0.06150257,0.049756628,0.021569343,-0.03549184,0.08148432,0.083933525,-0.08203655,0.116503164,-0.015970359,-0.04722685,0.009734182,0.0005508048,-0.04060997,0.038553897,-0.007358841,0.0025653623,0.061040454,0.0075612008,-0.059562933,-0.039952528,-0.044046123,0.034792125,-0.047178213,-0.04051028,0.077812,0.051487315,0.021533838,-0.0170883,-0.09583482,0.07454442,-0.04563061,0.042517383,0.02088364,-0.08148728,-0.024795614,0.02946446,-0.007496547,0.0678575,0.05940237,-0.03528269,-0.01795898,0.09166646,0.02241727,0.013676925,-0.014358141,-0.04368456,-0.0010711425,-2.2974313e-33,0.09802465,-0.0160917,0.013063214,-0.039323673,-0.056517243,0.05400732,-0.097260565,-0.08408139,-0.023718433,-0.006389219,-0.030108392,0.009307017,0.056396727,-0.03754418,-0.08658749,-0.09750367,0.109880246,0.1353557,-0.028842133,-0.040931217,-0.02011137,-0.013659116,0.007813069,0.017233005,0.008254758,-0.0800562,0.090880245,0.04348488,-0.043142464,0.08626426,0.023533087,0.008768193,-0.06087252,-0.06190244,0.0544436,0.07060577,-0.058677334,0.03729549,0.014073191,0.06332411,-0.018562995,-0.054657847,-0.007164307,0.056247395,0.07084044,0.023545984,-0.037728503,-0.0023203853,-0.060153022,-0.07698433,0.10446555,0.071191,-0.012169071,0.018390656,0.102945805,0.07655418,0.01614492,-0.12972933,0.078145325,-0.027027216,-0.026373224,0.009326705,-0.027170502,-0.09764747,0.06955567,0.03539042,-0.03958854,0.09608684,0.080571614,-0.01035755,0.07287884,0.03282709,0.07713076,0.11780854,-0.089009084,-0.07234621,0.06563733,-0.053268086,0.034239322,-0.07395272,0.010776376,0.039106615,0.071873315,-0.028068317,-0.12796389,-0.062554605,0.009458318,0.103851244,0.055339605,-0.04498165,0.0058936854,0.01833186,-0.04715152,0.05129146,0.013378024,-2.4441647e-08,-0.039698463,-0.07718979,-0.031200623,0.025456395,-0.022101805,0.005391474,0.03194679,-0.0022731202,0.019734884,-0.1114719,-0.012136928,0.025470316,0.015853697,0.09041289,-0.026848806,-0.010271698,0.030403677,0.07081211,0.014654619,0.027184822,-0.066271394,0.0039484124,-0.0581436,-0.027200105,0.044538464,-0.023911675,0.006493953,0.065250285,0.030180804,-0.032805774,0.03480971,-0.0039135218,-0.007981456,0.041744903,0.019694302,-0.0023707657,-0.033508833,-0.026343666,0.018136242,-0.07452218,-0.021677125,-0.009582961,0.00041812554,0.020674836,-0.02902313,0.015260791,0.009675554,0.03101046,0.0078286445,-0.00010730638,0.060878206,0.027265863,0.073418505,-0.114668734,-0.08501633,-0.016231896,-0.007914804,-0.08080135,-0.014023404,-0.10575646,-0.023494605,0.010666614,0.07965512,0.0672135 +2.1.1.121,Nororientaline is a precursor of the alkaloid papaverine.,384,1.0,-0.03636598,-0.0006857547,-0.08907705,-0.041082602,-0.028058073,0.029909112,-0.13623808,0.020178603,0.1092211,-0.045163516,0.002067875,-0.05139054,-0.016924338,0.0017898126,-0.035796005,0.029490648,-0.019074034,0.07488744,0.014664423,-0.031007726,-0.05021929,0.12688148,0.046176217,-0.04125023,0.036713768,0.07392114,-0.039119203,-0.038301293,0.12597428,-0.07164967,0.10051299,0.027470224,-0.037496407,-0.03353736,0.03056941,-0.0054378794,-0.050199803,0.015891261,-0.020486318,0.11417587,0.06265042,0.014011696,-0.062080633,0.025264636,-0.060826965,-0.039847948,-0.08662724,0.037640084,0.06519012,-0.042649098,-0.037641793,-0.08260432,-0.0124935545,0.015723174,-0.027067969,-0.04006451,-0.052868504,0.019717615,0.016650453,0.07919447,0.05425809,0.027867531,0.059802987,-0.015055571,0.03234943,0.03306394,0.0033972568,-0.07752638,0.0703992,-0.071884625,-0.0058007077,-0.048994813,0.086055726,-0.01967906,-0.037369825,0.012402577,0.0061718896,0.026414016,-0.03213101,-0.025299845,0.053277154,0.040126424,-0.027835501,0.09551926,-0.020432329,-0.010478617,0.011253964,0.064936854,-0.003274462,-0.06505758,-0.011377791,-0.03265734,-0.08060503,-0.027980644,-0.037438016,0.041070316,-0.012078802,0.05332151,-0.06856479,-0.03776295,0.042043753,-0.016441507,-0.14896704,-0.0027977948,-0.044176422,0.04385795,-0.011156716,-0.0064197714,-0.012865704,0.05248662,0.02589012,0.019618863,-0.060703598,-0.00852719,-0.038145423,0.04709434,0.054580897,-0.0010475906,-0.01649719,-0.0022568165,-0.0043954104,-0.051551335,-0.02075318,0.03558198,-0.024115061,0.043075316,-0.028024586,-3.7606186e-34,0.047763877,0.13575222,0.080570884,-0.070920005,0.017037822,-0.06848736,-0.06056866,-0.004023972,-0.0065622507,-0.119790666,-0.008537209,0.026630806,-0.043784004,0.014393244,0.040510405,-0.07534585,-0.059782702,-0.04914394,0.05634176,-0.06377358,-0.013291829,0.046741474,-0.0975761,0.06853033,-0.036830213,0.034468878,0.026430521,-0.038767107,-0.055966467,-0.07765808,-0.009182983,-0.1124863,-0.018523565,0.017786758,0.0052853213,-0.0035461606,0.017168866,-0.026691724,-0.018292744,0.023491193,-0.056781564,0.05896954,0.046140928,-0.008407469,0.015792971,-0.088156246,-0.04704732,0.07782265,0.035615217,0.014956546,0.0023306669,-0.028291885,0.041356012,0.02780788,-0.075518936,-0.015498813,-0.04641581,-0.025327649,-0.019035742,0.027412135,0.04408657,-0.05118504,0.011331297,0.0412596,-0.00065814296,-0.03999542,-0.06709323,-0.032830544,0.062096987,-0.015043542,-0.03804927,0.010723602,0.08954563,0.059447348,0.02940318,0.03166093,-0.007995117,0.09713733,0.08136696,-0.025202554,0.09871398,-0.069736205,0.029657757,0.041147124,-0.04087286,-0.0014290843,0.004279982,-0.0001445868,-0.008996139,0.07128623,-0.047553238,-0.024839105,-0.033434242,-0.027524166,0.011087376,2.705551e-35,0.109783836,-0.052821167,0.030687673,-0.019252224,0.010722573,0.027097596,-0.031154022,0.0563428,-0.019501075,0.0073418706,0.045763556,1.4336331e-06,0.1051462,-0.09439282,-0.022748783,-0.004733223,0.03637748,0.11301037,-0.02235976,0.025697893,-0.032451395,0.07146005,-0.1253536,0.048995912,0.050442237,0.071956046,0.062084965,-0.0006707485,-0.099060684,0.08857468,0.07268543,0.02758429,-0.06820215,-0.06220846,0.04622176,0.09040777,0.042588152,-0.015010725,-0.034025665,-0.062977135,-0.062248662,0.070480764,0.059065733,0.015373258,0.028864125,0.019016678,0.0058129025,0.019315138,-0.025902778,-0.010492613,-0.003672704,0.02849075,-0.020279834,0.06639091,-0.010781744,0.078674346,-0.002067339,-0.04731802,-0.0011435791,-0.028043529,0.038133256,-0.031180568,-0.04058107,-0.08190777,-0.0067679123,0.0057942057,-0.04647811,0.06725773,0.07208112,-0.008964875,-0.049141012,0.0370913,0.0014047524,0.041998573,-0.054473676,0.011474665,0.040348694,-0.092011824,0.030244935,-0.049103744,-0.05961883,0.0035884236,-0.032413993,-0.068932585,0.050411284,0.037816375,0.06857721,0.086254194,-0.02047528,0.031883836,0.01882013,-0.043695528,-0.14560874,0.07605514,0.023899224,-1.9844009e-08,0.06474376,-0.037252195,0.0041991207,0.043958228,-0.025119718,-0.025213223,0.0814504,-0.07571976,-0.023637764,-0.047025215,-0.011847214,0.024050198,-0.017895522,-0.025437523,0.025926528,0.036595024,0.0634717,0.013114758,-0.011441963,-0.012337901,-0.049274582,0.026238028,-0.011406675,-0.079696015,-0.016636793,0.012246761,0.09439721,0.036634486,0.110176526,0.02999329,0.02906082,0.010404639,0.028480083,-0.08871416,0.013288043,0.020634333,0.08427293,0.016727982,0.032634348,-0.06388518,-0.009482008,0.006544162,-0.0471716,0.04971452,0.020910311,-0.002594788,-0.028298566,-0.016529838,-0.0057965894,-0.018472731,0.045141622,-0.010772172,0.04150395,-0.047329947,-0.0882606,0.0066450783,-0.03968587,-0.029020833,-0.026422126,-0.08955192,0.017734528,-0.013234142,0.18231186,0.033072133 +2.1.1.122,"Involved in the biosynthesis of isoquinoline alkaloids in plants. Substrates include (S)-canadine, (S)-stylopine, and (S)-tetrahydropalmatine. ",384,0.99999994,-0.024021123,-0.0329369,-0.06427667,-0.022601876,-0.009013541,0.102242514,-0.03054776,0.0136074675,0.08309335,-0.034871932,0.06754641,-0.048180792,-0.014984818,-0.06676421,-0.04001933,0.06582162,-0.054642167,0.081736214,-0.014189804,-0.05638215,-0.015396179,0.032469835,-0.018139971,0.041057874,0.08105402,-0.005430128,-0.11469314,-0.015010376,0.022405967,-0.022348035,0.013081825,0.0050977324,0.02386385,-0.061709575,-0.04555274,0.070207484,-0.058520783,0.002651276,0.11033378,0.07867939,0.015725413,-0.049363334,-0.09447579,0.04792895,-0.045935668,-0.023407657,0.041212033,0.062349983,-0.014017557,0.015089432,-0.0016871645,-0.0028329242,-0.074845105,0.05231247,-0.01908056,-0.021127572,0.025348853,0.12389645,-0.0661072,0.030146863,0.053972106,0.010067985,0.0026942624,0.018504113,-0.048489407,0.019978398,-0.058360264,-0.0023241744,0.102010645,-0.060436852,-0.0005034979,-0.104958005,-0.03709522,0.020641195,-0.01880697,0.10431326,-0.051568884,0.0061446885,-0.026035191,-0.050739314,0.061657395,-0.015882088,-0.034423083,0.0596834,-0.03434498,-0.022196462,-0.02730975,0.032728102,0.052365128,0.01681276,0.074140646,-0.032735,-0.052515898,-0.029262569,-0.04091557,0.06530065,0.072093405,0.0007817809,-0.0034057207,-0.0557692,0.046367098,-0.011036007,-0.12067941,-0.043775313,-0.051842462,-0.0014481511,-0.08903319,-0.09725618,-0.046341814,-0.043192204,-0.009907899,-0.011840802,0.006062268,0.019430516,-0.0030190034,0.050248016,0.07379996,-0.057372905,-0.059226956,0.0003722911,-0.11654636,0.07027547,0.063715026,0.047806382,-0.0054368367,0.02085998,0.01282507,-1.5021133e-34,0.054942656,0.084856175,-0.01331764,-0.037753485,0.0005457651,-0.052103132,-0.052759748,-0.0030646792,-0.053239446,-0.034455243,-0.08177815,-0.034009952,-0.003796602,0.0058789523,0.07124315,0.022773903,-0.0007334547,-0.02691488,0.08045391,-0.046163872,-0.1100689,0.038352728,-0.10673498,0.024303837,-0.016448203,0.060053043,-0.006905142,0.010694488,-0.05097812,-0.04759111,-0.021712976,-0.06841921,-0.0129358405,-0.015625507,0.026056537,-0.012289498,-0.027379131,0.020326288,-0.027824176,0.040521383,0.05365419,0.076493375,0.03514879,0.013827433,0.03598974,0.04255184,-0.06476443,0.08831991,0.09207772,0.02707478,0.006491046,0.028143702,0.10672505,0.01958791,-0.03817431,0.031664044,0.011748174,-0.008304349,0.0074011153,0.055982213,-0.059931308,0.007861046,0.04439755,0.02554883,0.02708698,-0.011148664,-0.11508662,-0.004791642,0.007520995,0.03535463,-0.060968954,-0.026199572,0.007870182,-0.0049801623,0.03723385,0.029269353,-0.056694414,-0.048807427,-0.0042296257,-0.023192057,-0.03774517,-0.01370391,-0.001425408,-0.026826989,-0.068557546,-0.026456606,-0.015229646,0.0045483517,-0.008343029,0.054199018,0.0037135123,0.046903163,-0.07051729,-0.025050513,0.059089787,-2.4780409e-33,0.0470907,-0.07725475,-0.015736366,-0.053352486,-0.013369969,0.040274933,-0.10658249,-0.0041935076,0.03621025,0.096124575,-0.021903656,0.012841674,0.0061892737,0.040624775,-0.08353932,-0.09398616,0.009997243,0.18345264,0.03476565,-0.0029915175,-0.054564565,0.026257586,-0.051801424,0.09113488,-0.008054492,0.0148635,0.0047649452,-0.027997205,0.03232563,0.06453844,0.061315432,-0.031161308,-0.03290151,0.031550854,0.054460645,0.059742395,0.023221252,0.060067832,-0.015514802,0.012184961,0.024199156,0.031521354,0.019848589,0.025844133,0.053071823,-0.0035758093,-0.06901131,0.030919101,-0.09310244,-0.0070857736,0.079187214,0.018799523,-0.008988098,0.029141543,0.07967121,0.03980845,0.0018645389,-0.027879894,0.05711061,-0.04702196,0.0003192497,-0.06165933,-0.07141465,-0.074496284,0.005317641,0.053666137,-0.019608688,0.067501724,0.013071725,-0.03246657,0.1013696,0.0016204165,-0.007838974,0.08399684,-0.025099488,-0.01281354,0.008070108,-0.07021744,0.03342624,-0.02247536,0.00888188,0.002499605,0.031118475,-0.05098725,-0.061548963,0.011106274,-0.03238172,0.07758175,0.02140834,0.03991326,0.011351047,-0.013853451,-0.07482061,0.04757015,0.073181786,-3.206085e-08,0.05607652,-0.032392506,0.05913968,0.030472968,-0.063466035,0.0069586365,0.04321862,0.018832475,0.027014447,-0.04739496,-0.0069048875,0.0032335632,-0.011132507,0.065326266,0.093902335,0.016959108,0.047928534,0.02804131,-0.029546494,-0.006440179,-0.09245411,0.031879105,-0.05659685,-0.07347152,0.024634726,-0.11907785,0.041069012,0.06358452,0.06673753,0.021435626,0.08416054,-0.04217087,-0.032378916,-0.061876114,-0.031938035,-0.012742646,-0.025085904,-0.056203965,0.07321799,-0.003590229,-0.12113557,-0.059364546,-0.05224208,0.008658803,0.0070926575,-0.018162357,-0.006239847,0.028865162,0.0219808,0.0057176943,-0.021464858,-0.045876253,0.082329184,-0.13252981,-0.09440289,0.015053172,-0.0031134316,-0.020830097,-0.015471212,-0.1330443,-0.055415753,0.030071927,0.15844268,-0.024148604 +2.1.1.123,The enzyme from Euglena gracilis methylates Met-65 of horse heart cytochrome c.,384,0.99999994,-0.048249517,0.073435135,-0.063163236,-0.014902912,-0.088102005,0.052033246,-0.03611366,-0.016585423,-0.0143851,-0.044236813,0.028555516,-0.08771192,-0.005583994,-0.020218553,-0.01082585,0.004344914,-0.08429126,-0.10521273,-0.007901554,0.060805593,-0.044015218,0.009711022,-0.03340952,0.058509365,-0.037075743,0.015687136,0.01169997,-0.031918854,-0.04232835,0.009488032,-0.038975585,0.0018200227,0.09916619,0.04024398,-0.03630308,0.040980425,0.00014491328,-0.00046696782,-0.016874066,0.040855035,0.054560907,0.040556245,-0.0641195,0.06824017,-0.0018405067,-0.01213884,0.026226347,-0.06555192,-0.008278468,0.020244686,-0.01811856,-0.07273612,-0.044708945,-0.030800166,0.024462348,0.0032326137,-0.05461155,-0.03388852,-0.0044545736,-0.013297886,0.04528729,0.019896574,-0.03382934,-0.02507759,-0.04664735,-0.023853956,-0.00019107951,-0.03603906,0.030232627,-0.11468058,-0.013614097,-0.15566598,0.0037453384,0.006292923,-0.09896143,0.06106901,-0.006807544,-0.07744113,0.085576236,-0.04212842,-0.013653267,-0.027313294,-0.033151336,0.048724882,0.09778298,0.035653766,0.031966053,0.017757349,-0.008197455,-0.014451328,0.09088941,-0.020659864,-0.03999587,0.019119315,0.00873685,0.052841634,0.07264747,0.052404296,0.019419588,0.005933174,0.11492166,0.10413976,-0.046410006,-0.0655623,-0.0073898337,-0.024922304,0.043924227,0.083529554,-0.025045104,-0.020591363,-0.074045315,-0.009395677,0.041276533,-0.026319632,0.0026462688,0.109004386,0.03189551,-0.004814772,0.015811663,0.022860149,0.02038987,0.030281954,0.09042378,-0.036632814,-0.01708135,0.028368695,-0.06445357,4.8903967e-34,0.0008988511,-0.021916116,-0.013751268,0.00078756234,0.019878358,0.0070928354,-0.079362065,-0.01204985,0.0036985676,-0.049263522,-0.09129815,0.007097856,0.025494732,-0.0037169163,-0.051804528,0.069070354,-0.02597443,-0.045327406,0.05981624,-0.06007433,0.024423303,-0.018349128,-0.03501578,-0.095184885,-0.057355426,0.014305153,-0.05315578,0.024914687,0.04120793,0.0034029305,-0.027581908,-0.15707013,-0.029994993,0.019670332,0.028854817,0.058558196,-0.031363726,-0.017085752,-0.007809263,0.07565101,0.05128442,-0.014228665,0.07602784,-0.0347147,0.029688217,0.02282264,-0.11813744,0.122200675,0.0054119485,0.023193194,0.091263905,-0.047395255,0.041994236,0.03139175,-0.1005264,0.13301055,0.009393966,0.01202617,0.017306333,0.030363282,-0.0015074994,0.07944937,0.040149722,0.039082613,0.09826594,-0.053388692,-0.13561684,-0.02112948,-0.09614467,0.11258533,-0.01377973,-0.04850878,0.089516915,-0.100357465,0.0011211757,0.0043105795,-0.029233824,-0.0043497737,-0.055604704,0.015211982,-0.023719346,0.055113394,-0.003135757,0.019425878,0.008633253,0.011274229,0.028714951,0.009330285,-0.03655377,0.05168255,0.0703731,-0.01233517,-0.07226798,-0.102549486,0.040320326,-1.4769996e-33,0.07064189,-0.05228636,0.06958193,-0.10287401,0.058706857,0.0372979,0.03654446,-0.114792444,0.03574193,-0.009571953,0.12394554,0.021944428,0.018886682,0.032938194,0.011216214,0.04981156,0.033574346,0.098466046,0.01187215,-0.067538634,-0.061255634,-0.030611115,-0.034516647,0.06997741,0.019050643,-0.029331153,0.0046832776,-0.016893446,0.083867826,-0.030171452,-0.017835876,0.0014040762,-0.04518295,-0.008927498,-0.015885158,0.028752385,-0.02423673,-0.001842234,-0.005181408,-0.04002231,0.011899409,0.022943959,-0.009195704,0.043775987,0.07551152,0.068133645,-0.007822377,-0.031950187,-0.066187054,0.052328534,0.08300892,-0.024844542,-0.014235509,0.0042029475,0.03395617,0.04908377,0.02229025,-0.017617123,0.0030029656,-0.05226934,0.014967972,-0.029441196,-0.04337066,-0.0075248,0.0069593545,0.021665083,-0.0011753348,0.028260645,-0.019398453,-0.05144434,0.06307515,0.08844991,-0.07622009,0.010447214,-0.058033664,-0.014516525,-0.00040189017,-0.0014090296,0.04860888,-0.059803348,0.070459,0.01006617,0.0049755163,-0.01921499,-0.046999983,-0.04009408,-0.06709517,0.13419385,0.05819402,-0.0134056825,-0.05072508,-0.007586989,-0.08497431,0.05254403,0.050341725,-2.2101654e-08,-0.011108106,-0.056451373,-0.008542044,-0.057722073,-0.03340418,0.0700561,-0.053454652,-0.018516358,0.048480175,-0.042243652,0.085794486,0.046588216,-0.06723819,0.048532277,-0.045742847,0.05149571,0.013101307,0.043283343,0.038543034,0.0032380463,-0.045548435,0.05695946,-0.027787903,0.027590191,0.022641378,-0.07970203,0.040209696,0.11766013,0.017938461,-0.057222877,0.013895074,0.0017562797,0.040363826,-0.025378043,-0.004234003,0.011271493,0.014249861,-0.041347653,-0.02889073,0.057486482,-0.00066649105,-0.043667126,-0.07954125,-0.040285725,-0.0395735,-0.045277398,0.016251622,0.096547484,0.006699237,0.015019877,-0.018807948,0.058840368,0.08879419,-0.07551113,-0.07727962,0.031052925,-0.059074976,-0.064055,-0.018189192,-0.0383016,0.03862855,-0.001668325,0.13961782,0.023937343 +2.1.1.124,"The enzyme from Euglena gracilis methylates Arg-38 of horse heart cytochrome c to form the Nomega-monomethyl-arginine derivative. This enzyme was previously listed together with EC 2.1.1.25 phenol O-methyltransferase and EC 2.1.1.26 iodophenol O-methyltransferase as a single, now deleted, entry (EC 2.1.1.23, protein-arginine N-methyltransferase).",384,1.0,-0.05455831,0.04644226,-0.08305841,-0.008896917,-0.046012238,0.020907875,-0.008387294,0.010115758,0.066981904,-0.053712778,0.0638574,-0.05160498,-0.070986114,-0.013441201,-0.019978471,0.06241911,-0.13089189,-0.078553624,0.029291054,0.010706052,-0.01402452,0.04268288,-0.037996486,0.01735861,-0.00020587807,-0.029946659,-0.01600918,-0.031171475,-0.0011622084,-0.08940462,0.019824028,-0.021206947,0.061574046,0.00785284,0.004732524,0.0035858513,0.016225334,-0.061492126,-0.02105492,0.04325924,0.08220062,0.046425812,-0.11265857,0.03114425,0.005620456,-0.0018311439,0.043403532,-0.042382378,-0.02471062,0.027839074,0.0058579384,-0.080384195,-0.04330491,-0.047229227,0.04353177,-0.007043245,-0.08404303,-0.07149548,-0.0054976163,0.02083124,0.056046385,0.054196265,-0.037770066,-0.03507071,-0.032977212,-0.0021132897,0.046005968,-0.11234532,0.06268665,-0.08150357,-0.040411815,-0.16648445,-0.024665223,0.015837895,-0.10906286,0.06010955,0.004515954,-0.0051113716,0.09667214,-0.030127572,-0.016276589,-0.017322801,-0.007478671,0.0026702604,0.058448393,-0.00790031,-0.016772171,0.038941212,0.021919325,0.01593492,0.06809215,-0.039105278,0.019386023,0.028601315,0.032927144,0.027560972,0.028205995,0.06426543,0.0021135863,8.304414e-05,0.08512093,0.10308892,-0.05759653,-0.05104091,-0.001624578,0.02365199,0.056557782,0.058683936,0.0027897493,-0.0077301366,-0.09751812,-0.016494764,0.04738389,-0.008428767,-0.036103163,0.1115577,0.006578827,-0.0151764685,0.0097794,0.027085638,-0.008298607,-0.012516818,0.06556836,0.029731136,-0.0158081,0.101871856,-0.07611538,4.7764086e-33,0.013041041,0.012480971,0.009527959,-0.0420072,0.029943438,0.011292369,-0.061169937,0.020578435,0.032459415,-0.09956133,-0.09374767,-0.011181119,0.0054443623,0.01891699,-0.01901209,0.01910935,-0.030158125,-0.013624475,0.07568648,-0.010416048,0.004753035,0.019494032,-0.060257867,-0.041486893,-0.04676459,0.03599839,-0.015925754,-0.0036201703,0.037886072,0.00020187088,-0.047074743,-0.19272804,-0.017043801,0.004539717,0.017902477,-0.0022094385,0.017780747,-0.0066954894,0.029997028,0.09967127,0.030618284,-0.003933192,0.06122216,-0.055086847,0.03395947,-0.018143773,-0.11245992,0.119794935,-0.0026265823,0.04006864,0.0125415465,-0.03441647,0.059733033,0.014776441,-0.07320063,0.093607195,-0.026996506,0.018700441,0.018948594,-0.027203713,-0.003033151,0.05643433,0.07189945,-0.010873502,0.059146903,-0.038406454,-0.10290272,-0.02473699,-0.089158975,0.06339592,-0.011725419,-0.011766795,0.06772554,-0.09339986,0.049736172,-0.043841112,-0.06791619,0.03476541,-0.02076682,0.0033673372,-0.036325417,0.10455402,0.049194254,-0.001614877,0.044297576,-0.008819989,0.07001448,0.017568571,0.0030364334,0.059806924,0.035917412,-0.0024461113,-0.116605915,-0.071001254,0.05367134,-3.2311713e-33,0.031775706,-0.04632447,0.013900001,-0.08681494,0.02275048,0.061744675,0.04913092,-0.013615335,0.033916164,0.010129475,0.11859684,0.019504935,0.03903093,-0.047274794,0.046165586,-0.031829696,0.0041920296,0.10587346,-0.0076868734,-0.03759023,-0.057376876,-0.026058787,-0.052187935,0.08573535,0.007158613,0.026343562,-0.022056386,-0.016198225,0.046209138,-0.00569112,-0.02007331,0.026286038,-0.018091299,-0.015326345,0.011302791,0.008674855,0.053368874,0.042514097,-0.06610413,-0.059070878,0.005756444,0.029955134,0.014693089,0.054895964,0.06759348,0.094370745,-0.014144103,-0.029112622,-0.055548973,-0.011376851,0.08200848,-0.029780017,0.014190962,0.028811371,0.023455681,0.01367683,0.07795376,-0.013329019,-0.03622032,-0.034975797,0.008926432,-0.04973748,-0.016603585,-0.021298777,0.04570357,0.017566392,-0.030294806,0.04983446,-0.030746724,-0.057795875,0.03919596,0.07848132,-0.058466088,0.04569125,-0.025249552,0.005766175,0.0029443367,-0.047396615,0.030861221,-0.10729475,0.037177466,-0.047995552,-0.010209217,-0.03850499,-0.04861915,-0.042440213,-0.018503238,0.13607483,0.043393236,0.050042674,-0.051985126,0.0155711025,-0.114069946,0.050445616,0.019138778,-4.3330473e-08,-0.00055971555,-0.06600727,-0.012438435,-0.013891904,-0.056660548,0.08341054,-0.058795094,-0.009074629,0.045059513,-0.028872203,0.08912815,0.037782118,-0.055050824,0.04869188,-0.029999753,0.049758647,0.026735373,0.046342984,0.054181483,0.0085666,-0.061149135,0.09360768,-0.00954478,0.0019666294,0.053653978,-0.056081288,0.060738884,0.11164492,0.046234835,-0.08378878,0.036662985,0.020563997,0.02770743,0.012149117,-0.045039535,-0.0070758383,0.05970666,-0.01485081,-0.0048182798,0.06646533,-0.061016414,-0.020629968,-0.08226695,-0.024212638,0.023520468,-0.023015656,0.033417434,0.032659408,0.003557912,-0.005674043,-0.01736277,-0.006165723,0.058253795,-0.10740362,-0.10123629,-0.027058866,-0.067982174,-0.075744405,0.023359746,-0.032156475,0.071975976,-0.0027514477,0.14377831,0.043814156 +2.1.1.125,"The enzyme forms the Nomega-monomethyl- and Nomega,Nomega'-dimethyl, but not the Nomega,Nomega-dimethyl-arginine derivatives. The name protein methylase I is misleading since it has been used for a number of enzymes with different specificities.",384,1.0,-0.0021820047,-0.026344894,-0.07788111,-0.06356093,-0.009976169,0.017672976,-0.027201874,0.007660937,0.03547025,-0.05591428,0.058302406,-0.06684671,-0.035928268,0.03978917,0.010527584,0.08218792,-0.09730329,-0.07380655,0.033940326,-0.026121045,0.07925634,0.090171516,-0.05244965,-0.045695696,-0.017961834,0.007311528,-0.008994911,-0.036110323,0.05139973,-0.09058938,0.013465051,0.005938042,0.036777876,-0.013723629,0.09445654,0.043646306,-0.05543053,-0.04241787,-0.044694543,-0.009978465,0.114618234,0.0484335,-0.031717088,-0.028184561,-0.11488376,0.004052823,0.026417077,-0.029034019,0.0070164665,0.0149936825,-0.020763205,-0.13470751,-0.005904847,0.0074325986,0.036650497,-0.02935589,-0.04505526,-0.070128165,-0.043462273,0.052517872,0.02903827,0.034580383,-0.03274902,-0.018411454,0.014718485,0.027960945,0.040569723,-0.11134749,-0.018516133,-0.062025063,-0.060592514,-0.074803516,-0.05254259,0.037890915,-0.080410756,-0.007092779,0.033085044,0.044880386,0.091099806,-0.027431503,-0.025871867,0.039885193,0.008281271,-0.01198214,0.024456691,0.0330054,-0.02114807,0.066751204,0.08612211,-0.031363305,-0.030590476,-0.04510361,-0.04222859,-0.01844475,-0.007880613,0.014405787,-0.033249464,0.050518546,-0.00027809053,-0.036701452,0.053863313,0.021766886,-0.08097705,-0.055625636,-0.036476642,0.071656585,-0.007941235,0.040488537,-0.013901656,0.03073699,-0.0391985,0.07333014,0.07378864,0.010534435,-0.04117231,0.004034196,0.004944873,-0.0023489557,-0.012395695,0.00977808,0.016547386,-0.023192419,0.052306816,0.050315227,-0.031180074,0.08082145,-0.14665647,9.85282e-34,0.026470143,0.03243204,0.038020637,-0.06816509,0.025862744,-0.0014495467,0.025030676,0.06833837,0.0019013396,-0.040682793,-0.06072673,-0.08544084,0.0054227267,-0.0011897796,-0.032097366,0.0020157266,0.01988669,0.012013779,0.0019413418,-0.013413421,-0.03086298,0.12890452,-0.032837786,0.02200571,-0.011586478,0.01946933,0.03013982,-0.041241407,0.09137388,-0.036219537,-0.042257637,-0.1452731,-0.06515923,-0.004628763,0.1166419,-0.014796549,0.011619922,0.003585328,0.0033927523,0.07326017,0.011100707,-0.02078902,-0.02106368,-0.046559956,-0.017185174,-0.014240241,-0.08477819,0.03852576,-0.0010685212,-0.010395178,-0.024748994,0.0068937666,0.046508834,-0.07283236,-0.106677055,0.03314571,-0.0036244208,0.060996313,-0.046566155,-0.004255912,-0.07971195,-0.03657114,-0.030029992,0.010751326,0.013242142,-0.040065743,-0.023744715,-0.03848178,0.010586641,0.08001949,-0.019930487,0.0076919864,0.054637674,0.0030795617,0.07879775,-0.07598203,-0.093794316,-0.0438866,0.056751613,0.057346404,0.012748542,0.07649868,0.018147863,-0.06973128,-0.07574173,-0.026560837,0.05819141,-0.03741726,-0.007703876,-0.038268913,0.01796222,0.0011505508,-0.039261118,0.037415363,-0.013209514,-3.3027053e-33,0.028467104,-0.07950171,0.06436633,-0.092518345,-0.0124984095,0.03708319,0.06220608,0.024451742,0.025473984,-0.03386281,0.13663365,0.0046860785,-0.04820719,-0.083924,0.08184416,0.052047476,0.00047564117,0.07778548,-0.01325248,-0.008299198,-0.026263023,0.029754313,-0.088816725,0.0681819,0.033856787,0.027762342,0.0018255129,0.09050604,0.08546515,0.06299418,-0.040347774,0.02296113,0.0013616398,-0.06253579,-0.0010026678,0.012607502,0.03242717,-0.04964753,-0.034525767,-0.015441414,-0.0195679,0.06009187,0.075383425,0.10222028,-0.015249291,0.048978645,-0.11029315,-0.029080981,-0.045453746,-0.054092977,0.0045162113,-0.06392169,0.015616598,0.02460932,0.017945182,0.026533037,0.05113063,-0.0015294482,-0.047280308,-0.027888691,-0.0106884185,-0.052689634,-0.0065957657,0.04387285,0.011930444,0.07197797,-0.030487288,-0.038604,0.023211543,-0.03357779,-0.02964527,0.03756026,-0.055389997,0.00930791,-0.049533717,-0.02485596,-0.035157144,-0.015828615,-0.027068704,-0.0974153,0.040235363,0.021121105,-0.037378594,-0.050238036,0.018614143,0.00365975,0.07969519,0.13806885,0.029930666,0.086784825,-0.051633645,0.029328777,-0.04482092,0.11337664,0.018890787,-4.1055713e-08,0.036866616,-0.10704846,-0.01774581,-0.06677418,-0.050463494,0.061032746,-0.018802946,-0.061496444,0.056083404,0.06870681,0.031248,0.009342292,-0.056402225,0.04312747,-0.006282449,-0.006763942,-0.023305353,0.04512642,0.026014358,-0.0022656305,-0.031857897,0.08603529,-0.06672771,0.018484721,0.043066896,-0.025661528,0.014770228,0.1158301,0.046612307,0.0006974659,-0.021372953,0.07278916,0.041754637,-0.043735873,-0.07466797,0.045413807,0.085513435,-0.048336998,0.034080807,0.05100851,0.02547027,0.016456848,-0.022856772,-0.015154729,0.05309643,0.0066715796,0.011776015,0.025289005,0.05665278,0.017464442,0.032519996,0.0142050525,-0.033649214,-0.051199906,-0.0944606,-0.03019394,-0.10445665,-0.048186474,0.011568497,-0.06779345,0.054215703,-0.051212512,0.18702282,-0.02017634 +2.1.1.126,"The enzyme from mammalian brain forms the Nomega-monomethyl-, Nomega,Nomega-dimethyl- and Nomega,Nomega'-dimethyl-arginine derivatives. The name protein methylase I is misleading since it has been used for a number of enzymes with different specificities.",384,1.0000001,0.008133837,-0.031401273,-0.076231286,-0.05465862,-0.039015453,0.032688532,0.013036537,0.007922402,0.05022288,-0.012094753,0.060347956,-0.06493683,-0.052875273,0.048560195,0.001795189,0.0808745,-0.12250456,-0.078799464,0.040227465,-0.026037483,0.05131268,0.077052616,-0.071501285,-0.043153387,-0.014470521,0.043946747,-0.0053797374,-0.058935605,0.05089828,-0.06854826,0.029939916,-0.017535686,0.013198579,0.002472004,0.08404893,0.037990086,-0.08772984,-0.050173063,-0.044949096,-0.022170845,0.11880319,0.02942515,-0.03484764,0.0009346578,-0.08597496,0.01802121,0.040891495,-0.05749589,0.00718371,0.020124508,-0.026129136,-0.10234176,-0.03385812,0.030701553,0.0159177,-0.023692092,-0.057773307,-0.0270381,-0.038139652,0.080011666,-0.02021654,0.041787405,-0.016754696,-0.036343023,0.042293057,0.042502776,0.029857967,-0.10840808,-0.041463684,-0.066459626,-0.03795893,-0.06523971,-0.04127325,0.012880133,-0.08081187,-0.004855562,0.03927663,0.019668054,0.08393598,-0.042863075,-0.03256455,0.06606224,0.0019234223,0.0051206728,0.07988802,0.04937357,-0.014355965,0.10125707,0.049924076,0.008585488,-0.0633787,-0.07852487,-0.056112565,-0.03142755,-0.015363521,0.014397278,-0.014384931,0.043254226,0.042240005,-0.01829889,0.060369227,0.0077782036,-0.0607054,-0.033916328,-0.013085659,0.08801601,0.01854433,0.020987066,0.0025844055,0.012328122,-0.052530397,0.073755346,0.0354808,0.034395274,-0.028458407,-0.015213928,0.010555901,0.021881063,0.019975476,-0.01599741,0.012083171,-0.019377414,0.042100012,0.02397315,-0.02454733,0.045548897,-0.15456757,7.641674e-34,0.018012635,0.0041036853,0.028672513,-0.056448583,0.035170633,0.014050349,0.034006257,0.05480341,0.012146205,-0.04163832,-0.055923365,-0.07833986,-0.0042380444,0.056633398,-0.03128062,-0.02225595,0.0037475736,0.0073300474,0.021196738,-0.07691419,-0.044694103,0.1176328,-0.030662343,0.026777223,-0.029453892,-0.0140806055,-0.032505773,-0.026256697,0.085712515,-0.03273913,-0.07300783,-0.13499679,-0.075012855,-0.01785392,0.070846796,-0.007774295,0.03023236,-0.0029059488,0.005738572,0.08925651,0.0677252,-0.037585765,-0.027967023,-0.03002684,-0.02111458,0.022934858,-0.07811924,0.026122488,-0.008186429,-0.047252536,-0.032256074,-0.01718399,0.04648793,-0.07908388,-0.11223389,0.021273572,-0.027270356,0.045068838,-0.037338793,0.018408412,-0.058985416,-0.033880338,-0.02806427,0.029941415,0.02205076,-0.055478375,-0.036071133,-0.06027111,0.0027742148,0.059864644,-0.008761085,-0.020618683,0.059493165,-0.021110376,0.06357243,-0.05173592,-0.083181314,-0.013590223,0.030407235,0.040199388,0.0070042466,0.0719485,0.0003897738,-0.058592387,-0.050373666,0.013634513,0.090432644,-0.055314302,-0.033332195,-0.05240354,0.013990229,-0.006516791,-0.00940054,-0.011201249,-0.015921375,-3.1054584e-33,-0.014572096,-0.084185965,0.08928562,-0.079188615,-0.015572889,0.06470037,0.07667333,0.003356815,0.0062517435,-0.04046816,0.11600396,0.0018600423,-0.011195236,-0.079919614,0.08881991,0.013213885,-0.029185044,0.092136964,0.021264784,-0.022853645,-0.020411499,0.043399114,-0.102437004,0.071132675,0.043044604,0.03247478,-0.026553875,0.07772966,0.072704956,0.070539095,-0.08956337,0.04887057,-0.020867879,-0.05517421,0.043839823,0.02063887,0.026561532,-0.06787872,-0.08010825,-0.019780504,-0.01608476,0.07517311,0.08249398,0.10728045,-0.004001711,0.034857426,-0.09869749,-0.010016111,-0.061790776,0.008346645,-0.0005724868,-0.054122135,-0.021573119,-0.008988361,0.005631965,0.025986195,0.0366284,-0.019404367,-0.013050643,-0.042008504,-0.028221166,-0.070641994,-0.016880322,0.04229366,0.0076127723,0.04873901,-0.006834231,-0.024545832,0.01937155,-0.03250859,0.011925811,0.06669804,-0.03969483,0.01328107,-0.042621464,-0.014885119,-0.031629086,-0.0048797913,-0.013284827,-0.066023774,0.052794285,0.0348232,-0.057333764,-0.039422467,0.010053637,0.0062610516,0.05621616,0.14238688,0.020526974,0.053451944,-0.06504886,0.007967355,-0.077223666,0.12427506,-0.025450308,-4.323089e-08,0.024461888,-0.11086356,-0.0021820315,-0.053012878,-0.035793893,0.04883531,-0.0054435004,-0.013890783,0.042576097,0.04819077,0.060769904,-0.017116971,-0.03754627,0.060029026,-0.019901283,0.030226665,-0.015162141,0.07416549,0.037608244,-0.027801227,-0.017631322,0.09168563,-0.03859278,0.043574244,0.045307204,-0.011797146,0.0056446926,0.14297444,0.015579658,-0.020687135,-0.011720864,0.07327951,0.060396913,-0.031684615,-0.054358244,0.010153125,0.09006828,-0.040826514,-0.0063817496,0.039433826,0.02862078,-0.0037166127,-0.009149929,-0.02517892,0.044015206,-0.01640709,0.027526714,0.05021332,0.061399236,-0.020854436,0.011430079,0.052333042,-0.033900168,-0.036324874,-0.07202003,-0.030992419,-0.10906062,-0.03892527,0.00016181271,-0.06707593,0.066336215,0.034435768,0.1977982,-0.037578396 +2.1.1.127,The enzyme catalyses three successive methylations of Lys-14 in the large subunits of hexadecameric higher plant ribulose-bisphosphate-carboxylase (EC 4.1.1.39). Only the three methylated form is observed [3]. The enzyme from pea (Pisum sativum) also three-methylates a specific lysine in the chloroplastic isoforms of fructose-bisphosphate aldolase (EC 4.1.2.13) [5].,384,1.0,0.0113117965,-0.052254442,-0.053650416,-0.055242732,0.081217766,0.11368522,-0.04699519,0.035157718,0.060040995,0.008928732,0.06124906,-0.0104332445,-0.008821749,-0.012060082,-0.0007737386,-0.014078936,-0.13064167,-0.010676715,-0.033258058,-0.02591736,0.10612713,0.0057195737,-0.073076785,0.022325192,0.08405055,-0.023880467,-0.0014350007,-0.091066964,-0.036066227,-0.03465916,-0.01583709,0.0069346675,0.13317601,-0.055067092,0.0917828,0.10365533,-0.013224673,-0.15342717,0.047927212,0.02216352,-0.05483682,0.0001485031,0.012486088,-0.077848054,-0.062392227,0.046270587,0.06885941,0.0010051044,0.03808616,-0.07131947,-0.003471726,-0.0449632,0.04726489,-0.018567178,-0.044348687,-0.034579184,-0.013814105,0.06306647,0.046275616,0.06069626,-0.045305494,0.0296141,-0.032058295,-0.022286767,-0.001806155,-0.024062522,-0.047880117,-0.055188745,0.019647956,-0.028463418,0.022224328,-0.044538017,-0.05313132,0.015472996,0.04893042,-0.0068904017,-0.008195942,0.0013178,0.0039588297,0.019888898,-0.011514276,-0.026463345,0.013801352,-0.02823207,-0.024583243,-0.030381516,-0.029090554,0.08295367,0.052604277,-0.03615197,0.065817,-0.007464002,-0.029673588,0.031145481,-0.03713425,0.059439156,0.012507479,-0.05014143,-0.012784169,-0.06285729,0.07462758,0.059955828,-0.055442408,-0.030171068,0.05405724,0.07947834,-0.025466677,0.050505936,-0.008633165,-0.035450347,0.034246415,0.034846395,0.050107565,-0.04504764,-0.034315173,0.07970056,0.0027081014,-0.105410226,-0.052927926,-0.020956464,0.048116796,-0.061340127,0.067481905,0.09302623,-0.04131792,0.027204646,-0.1388746,4.092926e-33,0.07872703,0.07611286,0.012203038,-0.08430771,0.0035601351,-0.04243537,-0.02561752,0.027664585,-0.034283258,-0.07305118,-0.101177834,-0.066370286,0.015450524,-0.045300964,-0.072255515,-0.023146594,-0.07769462,-0.032219846,0.029212259,0.039505333,-0.046154965,0.043550223,-0.036550373,0.07415797,-0.00054749683,0.035359487,0.0649813,-0.031910468,0.038400088,-0.015560143,0.03404994,-0.06820148,-0.097166866,0.058221206,0.0103024775,0.0059150783,-0.025628425,-0.02554024,0.034621093,0.07735051,0.10360781,0.03557995,0.06623166,-0.019663554,0.05647726,0.038115926,-0.0007086953,0.060246147,-0.01317523,0.0857248,0.073128596,0.06410063,0.03971786,-0.03200476,-0.073433615,0.023793532,-0.0064452672,-0.0040604034,0.046106867,0.037948653,0.010515997,0.020831013,0.04717538,-0.0075877183,-0.040808715,-0.023667146,-0.09318906,-0.02491609,0.051100433,0.113431916,-0.0616633,-0.05813325,0.08074062,-0.020791532,0.08696281,-0.02169387,-0.10034984,-0.008684446,0.017702928,0.08397663,0.030044831,0.07485319,-0.04370865,-0.032801744,-0.06654151,-0.04759911,0.035401735,-0.05305872,-0.0715266,0.055981673,-0.017419783,-0.039735634,0.018308049,0.06524152,-0.042663462,-4.5752396e-33,0.08686174,-0.10563825,0.102016404,-0.08613289,-0.010036474,-0.05895319,0.037027564,-0.0316347,0.023448847,-0.041955337,0.078133255,-0.009948504,0.049127933,-0.022763286,0.019740028,0.0654286,0.0022259133,0.11338789,-0.03457059,0.0442286,-0.071054876,0.020908285,0.0070301783,0.083911136,0.028356701,-0.025414445,-0.010216428,0.01051131,0.12224138,-0.009691882,0.055040453,-0.01224246,-0.0093778735,0.005184719,-0.004972621,0.049332153,-0.043534238,-0.031177051,0.07503768,0.030333634,-0.01247669,-0.035300735,0.043538824,-0.02362667,0.0207262,0.012197195,-0.05394069,-0.008036713,-0.02868092,0.0059690694,-0.017463572,-0.0053200456,-0.014299289,0.0801588,0.027735151,0.020272383,-0.038557027,0.11781844,-0.053744793,-0.020639634,0.006881378,-0.039675206,0.010668448,-0.0068635507,0.050643213,0.02500339,-0.083967,-0.026088938,0.014883101,0.017904764,0.03652736,-0.010318255,0.053479977,0.050002277,-0.010184393,-0.053477973,-0.09470431,-0.06328827,-0.10194232,-0.055156905,-0.012612756,-0.00683939,0.016933344,-0.023339352,-0.040647052,-0.09993445,0.030502204,0.06946849,0.031116517,0.003624921,-0.02562054,-0.060223967,0.009362033,0.06475149,0.11637135,-4.4597584e-08,-0.044236477,-0.051278424,-0.021328267,-0.065076105,-0.026295867,0.026071329,-0.018338367,-0.012566907,-0.022526829,-0.0348899,-0.0030269653,0.02418421,-0.045443103,-0.0390012,0.0132663855,-0.012038171,-0.05774087,0.024757309,0.03540935,0.07693753,-0.010937226,0.026102154,-0.06325979,0.007903693,-0.048948444,0.04645838,-0.020379499,0.03431876,0.018839609,0.013500549,0.09414899,0.051741403,0.021294031,-0.064919,-0.056267235,-0.0044768592,-0.031089013,-0.0070332238,0.025473787,0.022615913,0.028705344,-0.05998712,-0.09414613,0.020399552,-0.020694036,-0.050252594,0.0031994963,0.05565723,0.036685646,0.039463084,0.053896435,0.004285631,-0.015870297,-0.05424619,0.03172786,-0.034709528,-0.027319226,-0.051776256,0.057463363,-0.03762876,0.00015185184,0.008455651,0.1714087,-0.038869083 +2.1.1.128,"The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.",384,1.0,-0.027716128,-0.019810224,-0.117920145,-0.019355828,-0.03168911,0.061550442,-0.13227786,-0.044758514,0.07380585,-0.030581215,0.05223358,0.023302782,-0.03805779,-0.030214678,0.0044412776,0.10588448,-0.11814565,0.04184084,-0.05846018,-0.0076078605,0.045579758,0.06543391,0.07004107,-0.047068093,0.062366884,-0.028446065,0.014855122,0.054798964,0.07960808,-0.08644614,0.0022561925,0.07053678,-0.018144567,0.00034344487,0.040204283,-0.0038154174,-0.0030152719,-0.011648049,0.014850651,0.07022819,-0.003936148,-0.022306804,-0.087208726,-0.04510388,-0.025207745,-0.07158698,-0.06896346,-0.028001923,0.045081194,-0.097806714,-0.060874593,-0.100800164,-0.038687885,-0.0037120846,-0.010108816,-0.04397805,-0.011189645,0.017241772,-0.056458324,0.053522073,0.06247425,0.021962829,-0.0014314654,-0.0017251378,0.010087284,0.029800218,-0.015538863,-0.01900108,0.09362492,-0.057618644,-0.012706541,-0.10930274,0.008430221,0.034528267,-0.07467694,0.053624798,0.048080128,-0.020516194,-0.0061212704,-0.082065895,0.008184733,0.02228965,-0.032799315,0.047270168,-0.032873742,0.050149057,0.010005265,0.10042255,0.055238914,0.024138704,0.045688245,-0.018572805,-0.04402584,-0.096427724,-0.064260855,0.041843977,0.024789777,0.016086524,-0.01555583,-0.0493578,0.04204783,0.033243604,-0.11479411,-0.026025046,0.018421745,0.0956295,-0.03297539,0.009700323,-0.033973865,-0.02344741,0.028374199,-0.01079731,0.022740575,0.029907856,-0.047090627,0.03935038,0.008707507,-0.023635997,-0.0698184,0.027207628,-0.058115713,-0.022323756,-0.011162543,0.061562616,-0.029802693,0.05868611,-0.063116714,1.660272e-34,0.056289602,0.09106745,0.017570436,-0.09641531,-0.002856226,-0.028459594,-0.023457438,-0.015862366,-0.051581662,-0.08514942,-0.0578307,-0.08496751,0.021747677,-0.027995592,0.05565323,-0.038360797,0.030552562,-0.033092372,-0.0027164062,-0.0053638653,-0.01171025,0.0563448,-0.08607863,-0.042378165,-0.036430374,0.049581993,0.07757841,-0.043579657,0.012698605,-0.04951113,0.026680358,-0.11027971,-0.04231761,0.074961536,0.02183225,0.005253617,0.0014946392,0.023187613,-0.006947792,0.02693435,0.048526652,0.057389986,-0.0049844338,0.06411398,0.039848797,-0.03873668,-0.02974951,0.103821985,0.04366631,0.06281752,-0.017774489,0.046348587,0.08347788,0.033685397,-0.015673174,-0.010195007,-0.018814804,-0.005498644,0.03565041,0.025930349,0.011155446,-0.08841614,-0.0071845846,0.031502225,0.0067100152,-0.030077718,-0.05930699,-0.08735011,-0.025458364,0.050227247,-0.045862116,-0.046908546,0.03605801,0.06098333,0.013155293,-0.010410708,-0.041123524,0.0069088344,0.07069396,-0.013540099,0.0471879,0.0006539894,0.034030654,0.003886808,-0.017921573,0.044163328,-0.027517399,-0.025253912,-0.049966786,0.07436821,0.0882685,-0.043473948,-0.08527746,-0.016149748,0.024139427,-1.0891806e-33,0.08674216,-0.033954572,0.045618307,-0.10092035,-0.038558718,0.045032427,-0.01572452,-0.0188946,0.010614166,0.033729617,0.0480888,0.037168406,0.056596357,-0.04591672,0.04224032,-0.02923176,0.043088935,0.17441031,0.03936479,0.017325958,-0.07937195,0.052385535,-0.095182225,0.0864256,0.020560293,0.03605651,0.057988912,-0.011460485,-0.048602223,0.032298185,0.087487765,-0.016052436,-0.0573463,-0.02907479,0.03780595,0.07380218,0.013116149,-0.03267725,-0.03362542,0.064968064,-0.07181102,0.06279868,0.016121002,0.0019906815,0.04678033,-0.023369752,-0.054163627,0.05832659,-0.012675365,-0.04149303,0.09882611,-0.005727567,0.010695554,0.007209591,0.062501244,0.013556382,0.014718117,-0.027657475,-0.019333394,-0.053914297,0.014895508,-0.04724641,-0.02563685,-0.041097183,-0.012619115,0.10791538,0.09426236,0.05224674,0.039950166,-0.04469241,0.021024454,0.03620248,-0.044500798,0.00047525635,-0.05037896,0.019823745,-0.012090132,-0.019198112,-0.0034529644,-0.049635705,-0.025996735,0.002789368,0.01936751,-0.021856127,-0.007011733,-0.020902472,0.067907386,0.10941916,0.013116478,0.04160972,0.032586057,-0.021313762,-0.08199665,0.09209365,0.12845887,-2.986259e-08,0.06417711,-0.121727616,0.041673943,-0.019194763,0.022643905,0.013528126,0.046774715,-0.06432817,0.01771997,0.011270438,-0.024511946,0.011024766,-0.053535044,0.021996511,-0.0051332144,-0.06841755,0.07353183,0.080097996,-0.02723678,-0.028184434,-0.048293993,0.037264824,-0.06756184,0.002438171,0.024948161,0.00073145604,0.02357006,0.06767027,0.08640762,-0.025178209,0.06825165,-0.0061582658,0.017182421,-0.05658989,-0.030867165,-0.04451132,0.0777696,-0.016220354,-0.018840263,-0.0008649704,0.0077064023,-0.034142748,-0.000709743,0.0077702315,-0.0065381746,-0.019258903,-0.040148262,-0.018419988,-0.0037462674,0.014028824,0.070579395,-0.02623772,0.014167209,-0.12219941,-0.14751466,-0.033256836,-0.040422935,-0.032795247,-0.03970094,-0.05179758,0.050911237,-0.020566273,0.16634959,-0.05844366 +2.1.1.129,"The enzyme from the rice bean Vigna umbellata (Fabaceae) is highly specific for S-adenosyl-L-methionine. The enzyme also methylates 1L-1,2,4/3,5-cyclohexanepentol, 2,4,6/3,5-pentahydroxycyclohexanone, D,L-2,3,4,6/5-pentacyclohexanone and 2,2'-anhydro-2-C-hydroxymethyl-myo-inositol, but at lower rates than that of myo-inositol.",384,1.0,-0.016795442,-0.08276039,-0.04106371,-0.0030626534,0.03372219,0.020044789,-0.06804737,0.067022376,0.058995876,0.016800748,0.110574745,-0.06293118,-0.0063619753,-0.016804287,-0.06653223,0.091931514,0.0016988871,-0.004339373,-0.010584827,-0.018679706,0.049571116,0.054907,-0.038314544,0.006337935,0.08795983,-0.04229704,-0.031063994,0.06506839,-0.03884908,-0.08070033,-0.07214129,0.010128082,0.06301658,0.020967593,0.08494421,0.12520616,-0.015597881,-0.06323967,0.10193211,-0.020569513,0.04670494,-0.028891593,0.09897684,0.017880155,-0.007050045,-0.02258886,-0.026861757,-0.0319364,0.036047533,-0.042652026,-0.032692894,-0.08295805,-0.027490487,-0.005853662,-0.039725795,-0.012564281,-0.032003257,0.01800842,-0.0452684,0.07342936,0.035486743,-0.035955697,-0.029923622,0.01661624,-0.014906489,-0.037803743,-0.043587465,-0.04235126,0.07570837,-0.025311992,0.0084223645,-0.06659149,0.057133067,0.087387875,-0.032045044,0.00019136921,0.00014863428,0.026977217,0.07037581,-0.0638976,0.04050463,0.046624642,0.027024115,-0.045347914,0.046430886,0.032979567,-0.0142691415,0.025984576,0.0765883,0.023366712,0.035459585,-0.02046504,-0.055902205,-0.06750451,-0.020333823,-0.0060452987,0.090639904,-0.038225323,-0.0800018,0.0005154115,0.06483798,0.036494702,-0.09374153,-0.050805487,-0.07077843,0.004468837,-0.0028718447,-0.043959584,-0.018337054,-0.0104657775,0.031761717,0.02678347,0.0023800964,-0.0122465035,-0.0314452,0.001038972,0.05229342,-0.0549194,0.016732732,0.008271847,-0.05493304,-0.086317495,0.048019256,0.008004887,-0.05600411,0.009781467,-0.038306247,3.2126404e-33,0.019881187,0.02457685,-0.03302443,-0.02602587,0.043664202,-0.075919025,-0.030394018,0.012363073,-0.055295773,-0.04307733,-0.15824525,-0.043769833,-0.021550339,-0.017989015,-0.06835111,0.045836676,-0.046604384,-0.04407614,0.047896747,-0.06666919,-0.016291853,-0.04451571,-0.029255608,0.0065592625,-0.04709665,-0.013713926,-0.034907196,-0.04243271,0.072253846,0.007631327,-0.009189726,0.010012505,-0.045633014,0.047285583,-0.047780223,0.052901756,-0.113350905,-0.06217971,0.054951325,0.14455357,0.021528905,0.0745689,0.011707181,-0.015060144,0.033256445,0.014509561,-0.06996144,0.092403844,0.00895201,0.042857382,0.014914542,-0.05450292,0.050446227,-0.013243142,-0.08450995,0.0077648754,0.022949861,-0.018233933,0.0015396847,0.09213357,-0.02872145,0.028475903,-0.0032927776,0.0457769,-0.057422854,-0.033727597,-0.12959664,-0.011968634,0.022892622,0.08502484,0.031150622,-0.085081354,0.03344582,-0.037531216,0.041232035,-0.035267957,-0.028151935,0.0264477,-0.04285924,0.03869302,0.098632544,-0.0020674253,0.044079002,-0.025255749,-0.02828905,0.041510932,0.012565961,-0.05057871,0.014709349,0.038112592,0.06567466,-0.032045826,0.010706971,-0.005033297,0.021457981,-3.7738504e-33,0.041559417,-0.06086646,0.13791187,-0.073498815,-0.008761511,0.051815074,-0.008558725,-0.033788707,0.06410644,-0.006228154,0.10614398,0.012789851,-0.0036110799,-0.07262219,0.015732286,1.9615269e-05,0.0070928656,0.071651846,0.046490025,0.023764264,-0.049346454,0.05736858,0.02530063,0.022272082,0.05605763,-0.06038424,0.003899367,0.024795054,0.024924938,0.020591464,0.019620372,-0.03798562,-0.04163933,-0.021369135,0.0033207706,-0.00553242,-0.08618621,-0.042258624,0.029250199,0.0758461,0.021649476,0.09992712,0.015468419,0.013922146,-0.012841863,0.037884,-0.12884803,-0.02116999,-0.030703142,-0.089810416,0.013116461,-0.07877079,0.018434038,0.007934571,0.0059596975,0.08259976,0.019915652,0.013924041,-0.051067967,-0.058339883,-0.062100116,-0.084238976,-0.0360584,0.0058218483,0.07511976,0.097482145,0.015567999,0.03878887,-0.012031518,0.024819372,0.0004270701,-0.002490698,-0.033027373,0.054822873,-0.041574854,-0.02984235,-0.027916042,0.02823495,0.020363357,-0.0823786,-0.015385196,0.03449458,-0.026196817,-0.04492879,-0.017480472,-0.007735989,0.038498472,0.15685825,0.04487812,0.096718356,-0.007116187,0.05937189,-0.038778678,0.00067167386,0.10150307,-5.1302425e-08,0.083069436,-0.16322778,0.012555574,-0.027597439,0.009294244,0.03653257,-0.003431278,0.015617206,0.111936726,0.002242416,-0.032547835,0.094911754,0.013933498,-0.016035495,-0.03347844,0.028353333,0.021083226,0.06809504,0.002061018,0.013382971,-0.09902861,0.045176305,-0.024473676,-0.035141453,0.044516187,0.013135041,-0.0071852882,0.11609543,-0.0038729026,-0.012206307,0.02342337,-0.030627184,-0.022162283,-0.059233397,-0.10937276,0.0332189,-0.039698504,-0.064782865,-0.0503458,-0.0022288298,0.06718719,-0.06434986,0.027698148,0.051486146,-0.014254455,-0.010331989,0.038174577,0.02826125,0.03571936,0.0363038,-0.005992363,0.009910636,-0.0024519977,-0.07237509,-0.08435903,-0.056335293,0.024020372,-0.030861571,-0.061331,-0.08371962,0.004118367,0.008298134,0.14102258,-0.026163403 +2.1.1.130,"This enzyme participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway. See EC 2.1.1.151, cobalt-factor II C20-methyltransferase, for the equivalent enzyme that participates in the anaerobic cobalamin biosynthesis pathway.",384,1.0,-0.023120817,0.033042092,-0.1613751,0.010483916,0.107595876,0.03708827,-0.07854187,0.022788499,0.022441095,-0.057183776,-0.022598831,-0.11068777,-0.0034654103,-0.020767264,-0.009238687,0.054494526,-0.05928053,-0.05111096,-0.04363313,-0.061611075,0.008047016,-0.012592581,-0.0018232618,0.032866046,-0.024275824,-0.0029990817,0.023061365,-0.0041752025,0.02110248,0.010933284,-0.048228383,-0.010382279,0.064480975,-0.008420156,-0.0018753958,0.07336121,0.029670358,-0.0059464574,0.012551736,0.0054536536,0.03063123,0.06117622,0.0010579526,-0.010164626,0.014035728,-0.01229005,0.040815137,0.017014269,-0.03202411,0.028046634,-0.05179425,-0.03564138,-0.028515412,0.019226015,0.02047692,0.0385563,-0.04222339,-0.060011122,0.028226776,0.0012049268,0.057838913,-0.096203,-0.002207263,0.007085197,0.03382753,-0.055777114,0.071332514,-0.061111946,0.018902335,-0.07823547,-0.054141127,-0.10520136,-0.0725731,0.00932003,-0.032744262,0.061075512,0.029108493,-0.048814245,0.027994739,-0.025048528,-0.0058659483,0.029980753,0.016245877,0.013208294,0.03880025,-0.019436968,-0.0037977286,0.010009012,0.020156883,0.083938904,-0.052289404,-0.034249395,0.047069497,0.020104377,-0.11049066,-0.0037112704,0.08109499,0.1241181,0.028987296,-0.035572093,0.029571446,0.094408005,-0.037188753,-0.027083645,0.015550099,-0.056458343,0.09816429,0.16699158,0.028495362,0.05672757,0.0034892184,0.030279163,0.028606264,0.017010557,0.016149787,0.14632739,0.056152944,-0.03041916,-0.06514822,0.08053842,0.06704755,-0.016109657,-0.014812085,-0.03679172,0.0018966991,-0.047375955,-0.028660757,6.4535673e-34,0.04915107,0.007935741,0.0032895436,0.016099889,0.010688192,0.017505934,-0.12540963,0.022155311,0.032037955,-0.062718675,-0.0427191,-0.049549423,0.045132097,0.069842815,-0.101411276,-0.080234155,-0.006314538,-0.07863444,0.04179558,0.033148088,0.0092759235,0.05688554,-0.042904608,0.012533679,0.05057339,0.038367968,0.018257672,0.029492356,0.008294826,0.009240805,0.002579237,-0.09078735,-0.11456395,-0.050786275,0.069861606,-0.019971171,-0.011215716,-0.000779405,-0.0029291408,0.04962673,0.02637407,0.023925655,-0.09195798,-0.010702714,0.011251962,-0.099406175,-0.012793852,0.11314655,0.05843736,0.039097212,0.002780215,0.008440419,0.10800383,-0.0047391476,-0.021214118,0.011649516,-0.009628126,-0.035277195,-0.02998362,0.04593279,0.03641747,-0.011895998,-0.016788127,0.12180698,0.02414853,-0.045404747,-0.06172366,-0.029785195,0.02285408,-0.0047133127,-0.06754407,-0.06294905,0.073353074,0.057018846,0.016608778,-0.07010812,-0.07901372,-0.07997496,0.0254327,-0.053494934,-0.041025333,-0.00750689,0.02094575,-0.048762284,-0.08531936,0.0063061817,-0.017866945,-0.054284845,-0.032823633,-0.069078036,-0.0330415,-0.00862806,-0.026085474,0.03874471,0.043569375,-2.8526432e-33,0.0621287,-0.048851285,0.06693226,-0.14066985,-0.024233818,0.083801754,0.02775667,-0.089542046,0.009336136,0.0039771493,0.10564385,-0.0157001,0.031097835,0.014542811,0.015002015,0.011244549,-0.039150298,0.096271954,-0.008860799,-0.015999442,0.006204138,-0.010480515,0.0019088794,-0.0058594886,-0.010512469,0.0892237,-0.021835977,0.06270743,0.060374446,0.09596627,-0.055370152,0.034113448,-0.012286229,-0.052662376,-0.010925958,0.061906595,0.0011513169,-0.027666876,-0.031472098,-0.0135162,0.0014995176,-0.0049331603,-0.019622479,0.053036056,0.059936345,0.06075747,-0.019950327,0.02977658,-0.06571091,-0.04236245,0.035504557,0.024763037,-0.07210792,0.10350302,0.07009399,0.030992366,0.0012183851,-0.0012422636,0.036918625,-0.09964675,-0.050328434,0.030560987,0.008820501,-0.01723694,0.028955739,0.0007391018,-0.0036813025,0.0441582,0.028788103,0.065609045,0.052089043,0.06071955,-0.015373671,0.029806402,-0.082553,-0.01973771,-0.039749727,-0.04295387,-0.074892916,-0.06594924,-0.05514853,-0.017443117,0.08639562,-0.04737331,-0.08559428,-0.08474835,0.03043247,0.045327514,-0.034093026,0.034146428,-0.050388683,-0.049875762,-0.09205103,0.025680365,0.030025508,-3.1115036e-08,-0.015122481,-0.07466173,0.03524038,-0.002473239,-0.02528692,0.084319904,-0.066394,-0.032368097,0.057169486,0.032419696,0.02847398,0.032866288,0.06409114,-0.027589811,-0.03705401,0.016631898,0.008741116,0.036433145,0.022827592,0.037141297,-0.052427765,-0.023490557,-0.011854309,-0.002362512,0.043553244,-0.07583509,-0.056199938,0.08915769,-0.008075933,-0.064090125,0.013584926,0.03431465,0.08791157,-0.05855553,-0.095496885,0.03760382,0.024162924,-0.04595825,-0.039266463,-0.025047528,-0.007529811,-0.045173023,-0.11130862,0.011125766,0.06475687,-0.0044076103,0.002540611,0.060623474,-0.038971957,-0.049546137,0.02740509,-0.05682088,0.007041176,-0.0059939814,-0.01472799,0.04358133,-0.07930688,-0.038188774,0.026645593,-0.0041800486,0.007448166,0.060026657,0.086583704,-0.14905004 +2.1.1.131,"The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. See EC 2.1.1.272, cobalt-factor III methyltransferase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.",384,1.0,-0.04799148,0.051782236,-0.16273841,-0.00497474,0.08627134,0.015366441,-0.052246347,-0.020146212,0.03625919,-0.020094965,-0.021474652,-0.094431214,0.003834186,-0.0054172087,-0.02428346,0.040049586,-0.05442698,-0.031041145,-0.013707444,-0.08935787,-0.060260046,0.018307887,-0.0076291054,0.012692084,-0.010260095,0.007102813,0.0053761704,0.004123228,-0.030951178,0.022443147,-0.07668181,0.052277282,0.012169094,-0.06416094,-0.0007070047,0.11249418,-0.028918771,0.012309222,0.01049097,-0.009310198,0.033113196,0.07720659,0.006161203,-0.016914666,-0.014074553,-0.025374085,0.025611898,0.034263674,-0.002150022,0.012798227,-0.059377175,-0.036291607,-0.044540845,0.0031159457,0.027540023,0.003484165,-0.024433099,-0.07888414,0.034555715,-0.029287504,0.07438296,-0.10058344,-0.0059218113,0.022018887,0.02799397,-0.08270844,0.08017835,-0.053263873,0.013932201,-0.071361,-0.04678389,-0.041620918,-0.061398976,-0.008446252,-0.00835059,0.06344556,0.045586325,-0.07455202,0.03412997,0.015024705,-0.035768107,0.008046844,0.035422217,0.039108068,0.06564349,-0.07368787,-0.0013862706,-6.5394255e-05,0.02515313,0.117943674,-0.019457588,-0.016350772,0.02823442,0.010549658,-0.097463705,-0.02346864,0.07496837,0.020543892,0.0010811791,-0.03226871,-0.021046914,0.11561733,-0.051876873,-0.042799447,0.01743297,-0.037903838,0.031171525,0.13633183,0.05391374,0.06613803,0.0078018666,0.03957157,0.05518422,-0.005223056,0.021636201,0.15421088,-0.0026281865,-0.025308574,-0.062142916,0.10767853,0.03985436,-0.014708742,-0.033284232,0.0016463711,-0.03133889,-0.057542555,-0.030705797,2.0325337e-33,0.10061831,0.029810078,0.012221442,0.01632803,0.035673667,0.022156391,-0.12877673,0.026353093,0.0070782453,-0.041851852,-0.05036363,-0.0895059,0.08054024,0.009329682,-0.051279448,-0.06676055,-0.03618869,-0.06006688,0.0068153455,0.025233196,-0.03266568,0.09826505,-0.045180596,0.017294277,0.009334969,0.0703111,-0.02620503,0.049918026,0.040909093,0.015222821,-0.0074471813,-0.044306576,-0.14555472,-0.023217851,0.06739054,-0.009097807,-0.042392816,-0.008154436,0.02830888,0.065763324,0.041086197,0.008382071,-0.06729786,-0.024810432,0.04301601,-0.043903783,0.03537538,0.11618842,0.054791514,0.08104748,0.0029483766,0.015617975,0.063279875,-0.024089584,-0.062378924,0.036929123,-0.027712993,-0.039931685,-0.0030389663,0.0453922,0.029374147,-0.0067046704,0.0034096178,0.113562085,-0.037959747,-0.044370443,-0.040494964,-0.10774738,0.021976657,0.00665369,-0.039017666,0.009965208,0.078757234,0.06220893,0.012657015,-0.027674293,-0.024538774,-0.109210856,0.053043906,-0.059290837,-0.034610048,0.038009293,0.0005738604,-0.06693272,-0.06674156,0.034624953,-0.010124751,-0.033194516,0.03224592,-0.017536063,-0.03773956,-0.013149042,-0.06451032,-0.005563659,0.022973068,-4.2908986e-33,0.115673535,-0.09764668,0.07191274,-0.12985753,-0.029260082,0.019418517,-0.009297229,-0.075816885,0.0018445047,-0.050343424,0.10097159,-0.053787623,0.0064977193,0.007581551,0.037856583,0.0029442806,-0.0060166186,0.09771002,-0.045529857,-0.02271186,0.014414682,-0.02844335,-0.03362957,0.014883202,-0.059525475,0.08178716,-0.057169516,-0.0005217041,0.067124814,0.10344745,-0.07771165,0.0026368685,-0.04723886,-0.0019500165,0.021393213,0.13489227,-0.028788041,-0.0009824461,0.03809163,0.043035854,0.035639398,0.04003199,-0.00879699,0.054013588,0.035258345,0.060766138,-0.04354383,0.03279209,-0.020786839,-0.039213836,0.062232655,0.008756294,-0.036141694,0.03637022,0.051574145,0.08655495,0.0020265293,-0.0039191255,0.011622449,-0.08069787,0.002134021,-0.014902149,0.0096558,-0.06725869,0.024090331,0.01968525,0.002061277,0.00037702365,0.080935046,0.03640059,0.023660574,0.065947816,-0.0017214873,-0.009476138,-0.057285987,-0.0485281,-0.011371601,-0.040453553,-0.061618198,-0.060621675,0.0050980556,0.06297226,0.067557715,-0.06672474,-0.05826284,-0.052764215,0.034544434,0.050402604,-0.021312803,0.020979462,-0.059818704,-0.05111877,-0.04498573,0.032869276,0.05937244,-3.703187e-08,0.008581688,-0.08262424,0.03359106,0.0020965836,-0.021313792,0.09255976,-0.04070874,-0.03716251,0.0647973,-0.00030843992,0.054147054,0.06296006,0.021051114,-0.0066751097,-0.024492962,0.031561323,-0.039268203,-0.008327554,0.0038331898,-0.029020915,-0.09056529,0.0006977565,-0.02944902,-0.009327074,0.015597167,-0.042754557,-0.047968924,0.076132245,-0.024989037,-0.060445547,0.012754805,-0.020340618,0.06787074,-0.058836386,-0.050680634,0.004396164,0.031010846,-0.05875829,0.010521715,-0.022606729,-0.002232085,-0.023383444,-0.13436897,0.029252896,0.025563471,-0.032480873,-0.030700821,0.096210286,-0.07743464,-0.019757316,0.036518097,-0.011842338,0.044903755,0.0055362787,0.008477509,0.04468431,-0.05032628,-0.042280067,-0.02473402,-0.017828869,-0.021833628,0.033546243,0.07729841,-0.16626257 +2.1.1.132,"The enzyme participates in the aerobic (late cobalt insertion) adenosylcobalamin biosynthesis pathway. The enzyme from the bacterium Pseudomonas denitrificans is a fusion protein with two active sites; one catalyses the methylation at C-15 followed by decarboxylation of the C-12 acetate side chain, while the other catalyses the methylation at C-5. The corresponding activities in the anaerobic adenosylcobalamin biosynthesis pathway are catalysed by EC 2.1.1.196, cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating], and EC 2.1.1.289, cobalt-precorrin-7 (C5)-methyltransferase, respectively.",384,0.99999994,-0.063803904,-0.0072056847,-0.12419788,-0.0124373045,0.049178362,0.046309166,-0.119153365,-0.021546768,0.016914776,-0.0039958344,-0.029404411,-0.08102795,-0.020646596,-0.0047808494,-0.03131686,0.031576373,-0.09169515,-0.019297728,-0.025289584,-0.013670814,0.0047623767,0.04134766,-0.09577666,0.04107682,0.06116121,0.0041665095,0.058060914,0.0063309874,-0.05184184,0.01632276,-0.07081295,-0.05006792,0.032500397,-0.037488293,0.04697708,0.15460904,-0.009813006,-0.0052773715,0.13318492,-0.03516149,0.011925339,0.046642147,0.0011437832,-0.024128469,-0.009493758,-0.006367675,0.02598498,0.05162934,0.039166022,-0.066761844,-0.009289125,0.012730048,-0.008981342,0.022658505,0.019236296,0.017235644,-0.037641313,-0.07343592,0.049283955,-0.023399035,0.03970402,-0.08237728,-0.011175596,0.022031387,0.010793637,-0.051128663,0.06551046,-0.028656159,0.0536073,-0.041797444,-0.08550123,-0.059912104,0.03646642,0.010801193,-0.029465256,0.016184747,0.04444945,-0.056621168,0.036922008,-0.053500116,-0.0010928717,0.057491384,0.044386536,0.015453253,0.04938054,-0.06474655,-0.013584246,0.009758648,0.021387435,0.0646653,-0.016481226,-0.0048986375,0.044776358,-0.050144468,-0.100678355,0.007682471,0.022293907,0.09022014,0.04156065,-0.036842354,0.02988226,0.09851078,-0.03879722,-0.06542817,0.05677557,-0.052083682,0.040616225,0.18140538,0.053498212,0.07061676,0.0069852606,0.05760426,0.0004075476,0.0022370967,0.01646318,0.1440115,0.0690089,-0.06821004,-0.07950847,0.027062912,0.027059916,-0.08147949,0.07117486,-0.0048136613,-0.007542431,-0.0704698,-0.06877772,3.7239073e-33,0.077153526,-0.0131943505,0.007114349,-0.011120404,0.028382434,0.007717045,-0.114608064,0.048396163,0.025403691,-0.02946608,-0.018096805,-0.07110082,0.046706323,0.031086577,-0.079522245,-0.05465915,-0.049607817,-0.058501713,0.0049202554,0.03426038,-0.030171366,0.061881747,-0.042788245,0.016101055,0.02380016,0.05181195,-0.0077343844,0.03992129,0.029370077,-0.0035961897,-0.016215876,-0.07060521,-0.114278965,-0.036598768,0.0822287,-0.0021747185,-0.015299829,0.03250991,0.025042253,0.09690929,0.073622726,0.023576707,-0.07685809,-0.050303273,0.049199495,-0.026022729,-0.024923705,0.11260232,0.023055866,0.072494745,0.0035805,0.007352957,0.114547305,-0.034462426,-0.034158856,-0.010348125,0.005040489,-0.018304368,0.024667846,0.06284123,0.05943316,-0.021706335,-0.021960856,0.059756,-0.014769131,-0.039567973,-0.059365425,-0.029409532,0.06549001,0.01957276,-0.06255629,0.025692584,0.06859443,0.061326683,0.010039522,-0.031850535,-0.06571931,-0.0134105105,0.03331018,-0.003450552,-0.04569545,0.043858957,-0.018877074,-0.049229644,-0.080781005,0.04822701,-0.00050092186,-0.05127508,-0.033055943,-0.052321717,-0.022177875,-0.05568894,-0.063076705,0.006546366,-0.009151675,-5.371766e-33,0.112839974,-0.08458028,0.06235816,-0.13176285,-0.04446126,0.072699666,0.029103184,-0.048351888,-0.0073475307,-0.041598924,0.10779241,0.0267589,0.032696605,0.037140254,0.0026705721,0.015623201,-0.016426686,0.082682274,-0.041118197,-0.013369908,0.04641702,0.031729665,-0.036658894,0.017493613,0.0332746,0.05625985,-0.03528787,0.06765579,0.04500744,0.092830084,-0.012180838,0.07473341,-0.047296513,-0.032707505,-0.033497747,0.06672537,-0.083604544,-0.016549142,-0.019285934,0.014233504,0.04095027,0.044187408,-0.09289216,0.062388085,0.025875678,0.05820819,-0.059937652,0.02371061,0.00021886016,-0.03639181,0.05105007,-0.009369644,-0.0560237,0.061579034,0.031091051,0.028583786,0.010499825,0.022673566,0.030724691,-0.07065407,-0.09802333,-0.028791577,0.018784974,-0.0795862,0.02580563,0.012765626,0.01648912,0.0522298,0.03680606,0.019981947,0.025355699,0.05611664,-0.0066020084,-0.006233353,-0.121459566,-0.0148031,-0.018292269,-0.06359578,-0.026998514,-0.016169721,-0.041149616,-0.022380413,0.017361954,-0.04606619,-0.06069854,-0.017894795,0.055632573,0.03758452,-0.09748637,0.041016642,-0.045048498,-0.057271957,-0.027283628,0.018193472,-0.030388042,-4.375367e-08,0.049991135,-0.051945258,0.050775472,-0.018972889,-0.010050277,0.12699501,-0.05222212,-0.053058103,0.043448657,-0.03616446,0.04060617,0.022763617,-0.018276166,-0.001574954,-0.06207355,-0.0012634788,-0.06068935,0.017375885,0.007474438,-0.009419111,-0.072679214,-0.019301016,-0.06655965,0.0060994914,0.06291742,-0.05206927,0.007678253,0.04997633,0.0013090838,-0.024323927,-0.03280573,0.03572517,0.047504716,-0.03945121,-0.024269199,-0.0034466407,-0.017265769,-0.020975178,-0.05594788,0.00321709,0.030691102,-0.07567286,-0.12027528,0.022606198,0.0036428901,0.019922605,-0.028053341,0.09149229,-0.040488347,-0.030606411,0.073480666,-0.0378956,0.031653635,-0.005470403,-0.03694421,0.048420634,-0.058175597,-0.06426763,-0.042753033,0.04944224,-0.02294442,0.041375525,0.092284925,-0.09541835 +2.1.1.133,"In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5, and precorrin-6A, respectively. See EC 2.1.1.271, cobalt-precorrin-4 methyltransferase, for the C11-methyltransferase enzyme that participates in the anaerobic cobalamin biosynthesis pathway.",384,1.0,-0.043598805,0.015363275,-0.12972917,-0.01818868,0.09425383,0.093897656,-0.11708935,-0.015928805,0.043775406,-0.017026069,-0.012066944,-0.07132634,-0.06565937,-0.051461257,-0.013035271,0.028702969,-0.0964405,0.005597507,-0.08141656,-0.01652727,0.008648741,0.015320317,-0.007901806,0.05043391,0.01796674,-0.06778277,0.0059872894,0.0024205772,0.0048973234,0.007866999,-0.010050254,0.038417224,0.016010333,-0.014004935,-0.010056152,0.08755733,0.008862576,-0.050652154,0.06448122,0.046630688,0.022313287,0.059071638,0.010331549,-0.013483746,-0.0044963635,-0.01260276,0.03359153,-5.945185e-05,0.0018582295,-0.05240293,-0.019045057,-0.013887761,-0.063183956,0.008350553,0.011347837,0.030246349,-0.07515445,-0.062406022,0.075042054,-0.001781019,-0.0014958783,-0.0701893,-0.016647927,0.007425105,0.01242301,0.030064741,0.05329176,-0.058446202,0.045323454,-0.035530765,-0.048258852,-0.068604305,-0.024300594,0.006888316,-0.071346216,0.11600255,0.039932325,-0.008440113,0.027263284,-0.062945925,-0.030601915,0.06908613,0.015980009,0.0071793175,0.024630664,-0.0020125739,-0.054992616,0.034082793,0.022447165,0.095518835,0.011797164,0.013241655,0.024697617,0.014387723,-0.12736,0.031270407,0.078491054,0.046094056,0.11201917,-0.028306145,0.055480618,0.07672196,-0.01717357,-0.028669348,0.049505174,-0.040758256,0.07342901,0.18848991,0.030347666,0.07706396,-0.02137557,0.074753806,-0.004815813,-0.0050667496,0.014295877,0.12544137,0.035169583,-0.046472773,-0.028799884,0.040574454,0.057074897,0.013300027,0.07257465,0.0036905524,-0.047914695,-0.051149517,-0.035569113,2.5328305e-33,0.056010425,0.015658395,0.027062641,0.00983634,-0.05576394,0.018900737,-0.11771132,0.023149556,0.025854392,-0.042405814,-0.031921986,-0.056737613,0.021735216,0.008333039,-0.070593864,-0.08659746,-0.009270416,-0.094673224,0.041657194,0.016024334,-0.023796855,0.07891118,-0.063547365,0.032741,-0.0015107042,0.053823177,0.018354144,0.04181451,0.022334682,-0.008383116,-0.025436936,-0.07319307,-0.063066244,-0.044081364,0.042426433,0.0119251525,-0.04503513,0.03177474,0.018130517,0.066657186,0.046209577,-0.00674239,-0.110249534,-0.03017666,0.0761227,-0.047329355,-0.054722335,0.09137167,0.034725707,-0.0034979878,-0.027992114,0.031044649,0.12068593,0.043342344,-0.060947627,-0.01341404,0.0060749236,-0.020198166,0.020861885,0.04256153,0.031281732,0.032273304,-0.031071119,0.11721315,-0.009326582,-0.022594362,-0.05078393,-0.029118488,0.009438306,-0.022501275,-0.031418495,-0.09361692,0.040433917,0.03218404,0.069920756,0.0109803695,-0.05499749,-0.04754434,-0.0212398,-0.039730266,-0.04927828,0.078360826,0.016565679,-0.044083484,-0.09604807,0.032012008,-0.030558303,-0.07045495,0.0035154335,-0.020810803,0.041918572,-0.03155801,-0.008445925,0.018880561,-0.012504537,-3.453224e-33,0.115981616,-0.036025904,0.0820168,-0.11678583,-0.028955711,0.068485476,0.083195694,-0.13761912,-0.048471928,-0.08196106,0.08358217,-0.030922811,-0.0025245503,-0.020153828,0.012579654,0.018113807,-0.022870423,0.09170288,0.043868896,0.03219767,0.024391184,-0.0054954137,-0.055498615,0.0038533565,0.00990378,0.07363124,0.024219342,0.0035773641,0.07873744,0.067881614,-0.024667164,0.025632516,0.004926232,0.0058717155,-0.038217656,0.06763329,-0.036129527,0.00010494103,-0.02332962,-0.007843093,0.0003483038,-0.027426692,-0.037838284,0.04074233,0.05248422,0.0620471,-0.044686846,0.02001347,-0.050846368,0.05413579,0.029949507,0.023592226,-0.0752636,0.026500244,0.079512,0.0007975374,0.083855756,-0.08164174,0.062337495,-0.078111134,-0.05969848,0.01364035,0.033304773,-0.06966601,0.054040097,0.012177285,0.029194545,0.101904415,0.036391713,0.019914242,0.03896483,0.06563688,0.020316806,-0.0215241,-0.03964539,0.004727499,-0.009842601,-0.046860714,-0.06700382,-0.06381357,-0.066492625,0.004599032,0.052968018,-0.016406521,-0.11812086,-0.04743831,0.05712334,0.00079729105,-0.04838776,0.062404156,-0.047553454,-0.028595418,-0.033331703,0.048824172,0.043315195,-4.546872e-08,0.009368208,-0.05721345,0.070967264,-0.005264761,0.015491102,0.068549566,-0.02983959,-0.005715192,0.03161856,0.0018834922,0.0031574897,0.056879636,0.05715532,-0.036032222,-0.09435831,-0.029367102,-0.08726249,-0.0118543515,0.019782431,-0.013064135,-0.049572334,0.00919238,-0.03865739,-0.0426438,0.06759933,-0.12348487,-0.09320915,0.10674192,0.018968856,-0.026950419,-0.010006127,0.043838203,0.061952535,-0.052505538,-0.008738895,0.034348663,-0.023385383,-0.03929239,-0.04977098,0.014373858,-0.06063643,-0.054344177,-0.08205297,0.017340658,0.022075415,-0.06846221,-0.030929254,0.06931947,-0.009674384,-0.032941055,0.014485196,-0.016415311,0.000412442,-0.008639126,-0.0340602,0.052850027,-0.059193667,-0.05619741,-0.010007996,-0.0018387589,-0.034119792,-0.010475433,0.045766246,-0.07987579 +2.1.1.136,"The enzyme from the fungus Trichoderma sp. virgatum, when cultured in the presence of halogenated phenol, also acts on a range of mono-, di- and trichlorophenols.",384,1.0,-0.019979134,-0.03790961,-0.09966354,-0.100860104,0.048440367,0.04002713,-0.053551592,0.02201921,0.036782566,0.009637998,0.11328799,-0.15097755,-0.056156553,-0.02723836,-0.088754125,0.010952508,0.011306619,0.014261225,-0.019403277,-0.04805023,0.025164586,0.021531643,-0.058798935,0.02602293,-0.05143914,0.060852,0.06278976,-0.020718597,-0.043890417,-0.109002285,-0.021574512,0.043691404,-0.036004692,0.010831078,0.009555449,0.061496057,-0.061310064,-0.026799312,0.0494163,0.07055943,-0.04503626,-0.028854337,-0.041699905,-0.0036054668,-0.06055163,0.0039403136,-0.059299905,0.05547744,0.058558937,-0.034167867,0.0075127254,-0.0041703167,-0.0033153722,0.008127883,-0.046574444,0.12854446,0.02122911,-0.035929374,-0.06474995,0.07702721,-0.022888172,0.029041,0.016868211,0.0019144018,-0.061168995,-0.0054038935,-0.005948973,-0.012068574,-0.023175929,-0.011884841,-0.088737234,-0.05588237,-0.021888958,-0.03558393,0.015978957,0.011916491,0.021280136,-0.020705646,0.046202943,-0.052531257,0.02329683,0.03217723,0.09955779,-0.0021732259,0.039605286,-0.04327558,-0.0069026654,-0.005980266,0.10017236,0.06525108,0.07332715,0.026767338,0.00082119997,0.018593512,-0.08507041,0.08480729,0.017886808,-0.023322891,0.030424591,-0.06798587,-0.0063425233,-0.09060742,-0.019743085,-0.08841496,-0.042137023,0.00950097,0.012957849,0.066185854,0.08564139,0.009260868,0.023725228,0.0076161195,0.06977991,-0.039994933,0.0060308822,0.08035822,0.07531806,-0.06960375,-0.041289527,-0.043570314,0.031561423,-0.042707726,0.024369098,-0.00831218,-0.06145641,0.07515568,0.011288646,-6.821586e-34,0.07915766,-0.03477478,-0.020571318,0.04751405,-0.04530389,0.031227138,0.007675941,0.017793726,-0.11536651,-0.1586542,0.0057278457,-0.04744988,-0.057003047,0.03207895,-0.009563411,0.060139824,0.010443477,0.0017193841,-0.029262172,0.026151666,-0.0150667885,0.036928605,-0.06803396,0.022856778,0.042292222,0.0749612,-0.05828828,-0.08656981,0.06137518,-0.0036870695,-0.008584891,-0.03277937,0.009953548,0.08223535,0.06817874,0.14100143,0.010365185,0.018274855,-0.07141396,0.03373447,-0.012347198,-0.017985966,-0.014942926,-0.060152438,0.03292473,-0.045744505,-0.07117643,0.08157021,-0.021340797,0.010786817,-0.011174629,0.058846325,0.06021138,0.052041203,-0.04039884,0.0951489,0.0063032424,0.015787933,0.046863247,-0.02960586,-0.057567533,0.13836408,0.013805535,0.092527166,0.028971024,0.011880824,-0.05331543,-0.09461716,0.010839091,0.079953715,-0.06743506,0.02465344,-0.021423804,0.027221045,0.055889554,-0.08022786,-0.028740067,-0.03239515,-0.01834549,0.006167625,0.011029172,-0.06300014,0.051394753,-0.05421003,-0.047944896,-0.006164642,-0.016953401,-0.005847191,-0.017993206,-0.008168579,0.079780154,0.01390304,0.0027417266,0.014371222,0.022559261,-1.366811e-33,0.08960327,-0.10427604,-0.041734066,0.03765522,-0.018849451,0.12366536,-0.0660016,-0.058098417,-0.08610721,-0.038163062,0.020452658,0.02656692,-0.064903036,0.0022694725,-0.022182072,-0.0036045704,0.081363834,0.08793498,-0.004631927,-0.042776596,0.010657558,0.03664808,0.052182317,0.059124194,0.018207986,-0.051554598,-0.044534687,0.061531253,-0.022926902,0.028714927,-0.010211084,0.03222105,0.049511738,-0.054739982,0.010223076,0.03783443,-0.026821932,-0.00019170689,0.034490407,0.070930146,-0.092393234,-0.03908903,-0.021958202,0.0030275178,-0.020062849,0.06548037,-0.061494786,-0.018679468,-0.016262552,-0.059370194,0.014349748,0.0041190526,0.011441834,0.043489356,-0.007432844,-0.0040082657,-0.015065364,-0.042681854,0.034133524,-0.031495266,-0.06963567,-0.040551085,-0.05888363,-0.030666085,0.060177583,0.05855469,0.027427485,0.059109356,0.05150646,-0.07217528,0.08722666,0.021730576,0.046783593,0.08288871,-0.03615935,-0.06368666,0.008214722,-0.01907073,0.013338949,-0.014367627,0.006226774,-0.0020711399,0.10556081,-0.051680803,-0.08572243,-0.111997426,0.029043164,0.044073038,-0.061146334,0.02194021,-0.04229574,-0.0032548055,-0.07887534,-0.016615365,0.06862803,-3.0627366e-08,0.07756125,-0.021372667,-0.018190213,-0.06316362,0.031196857,0.055049397,0.11139111,0.029622154,0.053600684,0.01762633,-0.08079932,0.04775485,0.037138175,0.0993578,0.08123359,0.06830208,0.0037690462,0.044077046,-0.020523172,0.022903629,-0.040223062,0.008429625,-0.058453575,-0.0067360774,-0.06530196,0.013165822,0.06384505,-0.0049142228,0.027615255,-0.009949296,-0.061813492,0.05456619,-0.023803119,-0.0076555694,-0.07299061,0.03556085,-0.04255162,-0.016474908,-0.011739456,0.045283332,-0.04639025,0.028705703,-0.042302612,-0.012894828,-0.0023954897,-0.041889478,0.03900375,-0.021391487,0.078181185,-0.031383548,-0.004004024,0.025852598,0.03327494,0.0077881543,-0.092838466,-0.02903434,0.07588588,-0.016931226,-0.046659913,-0.11088394,-0.021990318,-0.005738929,0.08478905,0.048313383 +2.1.1.137,"An enzyme responsible for synthesis of trivalent methylarsenical antibiotics in microbes [11] or detoxification of inorganic arsenous acid in animals. The in vivo substrate is arsenic triglutathione or similar thiol (depending on the organism) [6], from which the arsenic is transferred to the enzyme forming bonds with the thiol groups of three cysteine residues [10] via a disulfide bond cascade pathway [7, 8]. Most of the substrates undergo two methylations and are converted to dimethylarsinous acid [9]. However, a small fraction are released earlier as methylarsonous acid, and a smaller amount proceeds via a third methylation, resulting in the volatile product trimethylarsane. Methylation involves temporary oxidation to arsenic(V) valency, followed by reduction back to arsenic(III) valency using electrons provided by thioredoxin or a similar reduction system. The arsenic(III) products are quickly oxidized in the presence of oxygen to the corresponding arsenic(V) species.",384,0.99999994,0.01575373,0.008911947,-0.051607043,-0.05390143,0.040518552,-0.052084602,0.020986486,0.032823574,0.061800253,-0.03655692,0.030940346,-0.038203806,-0.01401047,-0.012858989,-0.037617676,-0.0065199197,-0.08792691,0.061848674,-0.040201638,-0.01736826,0.03780373,0.03695572,-0.038457736,-0.013630116,-0.07573301,0.055491872,0.080440715,-0.02204755,0.015063842,-0.024498021,0.0151816765,0.011215098,0.023661464,-0.054231714,-0.04406439,0.10904528,-0.060196515,0.014781856,0.030942813,0.0067852633,0.048553806,-0.03307521,-0.046630792,-0.0133937355,-0.11222583,-0.04238347,-0.00041128733,0.00038323976,-0.054484352,-0.01028264,-0.05624591,0.0151596395,-0.05358076,0.091276005,-0.004234088,-0.03802069,-0.011794224,0.018201875,-0.09296938,0.012926164,0.07338182,0.030611139,0.0013454075,-0.011519241,-0.034821697,0.008981666,0.07725219,-0.059875675,0.005999764,-0.058037896,-0.041475456,-0.029375924,-0.097671,-0.0055246498,-0.019971233,0.012072969,0.11939334,-0.07581487,0.04592773,-0.08844305,-0.013355704,0.048838414,0.09796065,0.05307319,0.06749844,-0.037040666,-0.078923635,0.035147626,0.0050074295,0.015198497,0.0689175,0.086292334,0.03153968,-0.09413209,0.007998335,0.06030704,0.015858749,0.017461656,0.043798726,-0.01371288,-0.0115255425,0.051595174,-0.19988024,-0.015066474,-0.04460962,0.0037472276,-0.031106891,0.042103335,-0.00053382665,0.022361625,0.013143441,0.049883213,0.04802555,0.049533814,-0.030298445,0.09885555,0.07950663,-0.05878689,0.003205923,0.0041687307,-0.022990696,0.008941996,0.066930905,0.025484756,-0.023340255,-0.036240023,-0.07370083,3.1697573e-33,-0.0027386553,0.13688919,-0.042044617,-0.034523837,-0.03296487,-0.038800247,-0.015482842,0.01944892,0.0036459093,-0.016120633,-0.042696472,-0.11892496,-0.02354502,0.04403753,0.03396759,-0.08205217,-0.039857022,0.06843844,0.056809068,-0.037058152,-0.0255168,0.039869804,-0.0077882437,-0.0006327637,0.017012773,0.05382318,0.018997252,0.056692384,0.024278512,-0.020284317,-0.02974148,-0.098380655,-0.036592163,-0.07796618,0.04427567,0.058009025,-0.060832247,0.04675366,0.014925005,0.065408394,0.007816741,-0.001457172,0.019652838,-0.021594401,0.0027216808,-0.0069347136,-0.10917971,0.056415092,0.07541647,-0.034518603,-0.006018721,-0.031792454,0.096908584,-0.057189498,-0.11045669,0.020127602,-0.033322047,-0.049656637,0.006383489,0.055159606,-0.00548934,-0.0028381713,-0.058629707,0.09351556,-0.008690285,-0.037270915,-0.02746777,-0.0651247,0.0028459257,0.076972984,-0.07486653,-0.017353237,0.064111054,-0.016299393,-0.009787629,0.008829961,-0.10131305,-0.052867778,0.10854035,-0.00075156183,-0.043458633,0.03062463,0.02959322,-0.05724705,-0.03313008,-0.07197173,-0.015639124,-0.015569122,0.014138359,-0.019839773,0.006541803,-0.108558394,-0.049490128,-0.030306796,-0.046859685,-5.1216116e-33,0.047709897,-0.03524236,0.05127915,-0.04764874,-0.00856168,0.06422207,0.024842357,0.044946037,-0.018990329,-0.05115194,0.060754668,0.054374326,-0.009677303,-0.028514644,-0.0031111778,0.014085042,0.06856779,0.04227736,-0.03223579,-0.0526028,0.058326326,0.015895294,-0.03179387,0.068469584,-0.048790213,0.0008019855,0.002195327,0.0617668,0.09599389,0.07073578,0.015710032,-0.003915952,0.0044313804,-0.05365439,0.027717367,0.08536504,0.000834909,-0.026744176,-0.039634556,0.027972482,0.05011162,-0.018311031,-0.010332121,0.099692024,0.026723232,0.059486162,-0.10379377,0.0029439977,0.009098771,-0.045386698,0.07424659,0.017154107,-0.023839502,0.060923394,0.048608907,-0.013995936,0.046371132,-0.045628823,-0.013460792,-0.02016083,-0.07368175,-0.06127274,-0.012150722,-0.07828227,-0.028387273,0.04193293,-0.050731894,0.026694426,0.00791455,-0.025622325,0.04304531,0.042840622,-0.010347424,-0.09811941,-0.10723391,-0.08847068,-0.020786766,-0.044052646,0.0020402984,-0.02025558,0.042379867,-0.015969317,0.023028731,-0.025960432,-0.024706356,-0.054154303,0.01651227,0.12445403,-0.060517833,0.0011467108,-0.073474355,-0.020725427,-0.016420117,0.02454253,0.002747121,-5.224566e-08,0.006991894,-0.060308255,0.06761985,-0.0055691055,-0.075955644,0.041807782,-8.764465e-05,-0.013295896,0.028009376,-0.07047013,-0.0074115936,0.042704828,0.03024581,0.036867667,0.0586168,0.008677031,-0.022809114,0.05001433,0.0028146913,-0.06414841,-0.07286711,0.037755147,-0.067660496,-0.05128186,0.056985598,0.009221597,0.0061365673,-0.017259989,0.03830777,-0.0038633693,-0.002235646,0.07247519,0.04152216,0.096167125,-0.024995718,-0.029239923,-0.00909635,-0.039170746,0.041958366,-0.021099927,0.01307835,0.057333585,-0.14401333,0.049611703,0.057019655,-0.04035896,-0.04140155,0.0873203,0.022324229,-0.003838261,-0.0019553592,0.018591296,0.024136739,-0.027884012,-0.03389702,-0.008560053,-0.06111527,-0.033364184,0.018763367,-0.029404566,0.16117927,0.0133166965,0.18805474,-0.049311385 +2.1.1.139,"Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.",384,1.0,-0.040259697,0.057036914,-0.099639125,0.03452006,-0.022072257,0.020905158,-0.04400289,0.02282683,0.07226518,-0.023212811,-0.027407877,-0.02101504,-0.0322677,-0.00632258,-0.070655465,0.051323492,-0.052651726,0.080231614,0.041985974,-0.054285172,-0.012628038,0.0709504,0.008864466,0.0750765,0.03436049,0.05522897,-0.008148722,-0.021404654,-0.056480527,-0.025834138,0.06406509,0.010070557,0.07239624,-0.08114423,0.0036202946,0.072288714,-0.043068357,-0.10189512,0.10505049,0.027641676,-0.026930487,-0.04036424,-0.01661193,0.07178739,-0.032427903,0.07230086,0.011584984,0.06346521,0.027001813,-0.023994958,-0.0064907335,0.010535448,-0.07562393,0.0652996,0.034952566,0.06781811,-0.06461476,0.10035873,0.01650584,-0.07156192,0.058520336,-0.010652927,0.025762191,0.061061703,-0.013050066,-0.014543807,-0.02899318,-0.033316795,0.067373306,-0.009979505,-0.06931416,-0.02113569,0.07675709,0.022015503,-0.019457,0.03359537,0.028294884,-0.022876626,-0.015085556,-0.024716008,0.12211355,0.0136384955,-0.0119541725,0.056239594,0.012998928,0.021294901,0.03926583,-0.055413585,0.04622156,0.03413748,0.106825136,-0.072515674,-0.014640473,-0.07084535,-0.061878823,0.0006076749,0.014070211,-0.002914843,-0.001211638,-0.016568813,-0.04427786,-0.004246967,0.0024182186,-0.0328219,0.03516466,-0.012579154,-0.025895612,0.008107629,0.0017872746,-0.02667119,-0.02980152,0.007813841,0.031328812,-0.01073172,0.009242375,0.14570443,0.045980852,-0.044777334,-0.017860692,0.0026917136,0.01900122,-0.018104969,-0.02992613,0.0073627555,-0.053819098,0.008788347,-0.036968064,-2.594358e-35,-0.06112593,0.038111642,-0.011250251,-0.0506623,0.062162157,-0.116349965,-0.019519387,-0.023476128,-0.033319507,-0.039943963,-0.10543703,-0.06864099,0.023802746,0.06750783,0.005976989,-0.035350364,0.0022857168,0.048992235,0.014100463,-0.008651551,0.041270312,0.02088616,-0.043627374,-0.018013608,-0.016105818,0.081746206,-0.0061649242,-0.020442376,0.003999381,-0.012168197,-0.07188528,0.0008048595,0.0071393372,0.0072636497,0.05370257,-0.03680499,-0.09073616,-0.08633736,0.09340471,0.05058238,-0.052971605,0.035499774,-0.08899324,0.03937907,0.05782937,0.025522068,-0.05005756,0.101211905,0.035388567,0.021608828,0.097858064,-0.052553814,-0.010575255,0.046319153,-0.007723273,0.026402446,-0.054140165,-0.074283876,0.04582208,-0.0071661277,-0.047467455,0.019346897,-0.03024266,-0.016290473,-0.018736396,-0.039390236,-0.08376795,-0.021554243,0.0071904683,0.007536335,-0.06164985,-0.01533924,0.031440366,0.03666611,-0.0517627,0.043192904,0.016126962,-0.030654227,0.026322773,0.022989389,-0.010924358,0.005625623,-0.027496189,-0.035363715,-0.00891095,-0.010615383,-0.035272714,-0.077458516,-0.062433656,0.07275481,-0.042208117,-0.059176166,-0.064100124,0.0072971643,-0.008163117,-2.6240902e-33,0.14236483,-0.106574155,0.04346513,-0.07205067,-0.052709322,0.1269426,0.009981081,-0.08104654,0.079854175,0.04105457,0.002575634,0.0030486945,-0.002025554,-0.047457542,-0.023191042,-0.053018473,0.021816013,0.093388855,-0.052506726,0.052916855,-0.003039711,0.044639558,-0.05927782,0.00917519,-0.0078049805,-0.014971303,-0.008947916,0.07302321,-0.045346525,0.085078984,0.02728724,-0.09755593,-0.020941012,-0.0071869483,0.008231557,0.11682241,-0.0057083704,0.020535829,0.009245676,-0.05355258,0.08293462,-0.0026163496,-0.021266246,0.020299017,0.08096575,0.0448577,-0.09802635,0.07677294,-0.044528123,-0.070566334,0.13807549,0.051134206,-0.007824904,0.009999054,-0.009428405,0.0014842575,0.006783036,-0.08398521,0.031345382,-0.03263953,-0.043642286,-0.098369345,0.08616493,0.02616628,0.033490464,0.0064010043,0.0031019922,0.06820265,0.089300804,-0.030630652,0.07456423,0.043024983,-0.036379136,0.0738646,-0.029662663,0.013577002,-0.08957906,-0.089072555,0.034588818,-0.015240556,-0.05894719,0.008628395,0.08627889,-0.042142544,-0.010103899,0.0038836012,0.047592927,0.054506168,-0.00799915,0.05252696,-0.023879262,-0.011812608,-0.037057254,0.03055609,0.08990169,-2.8269618e-08,0.051715277,-0.019702418,0.058657553,-0.012442924,0.0076904837,0.018233562,-0.015450479,-0.01880595,0.015571567,-0.059652127,-0.022417676,0.05270221,0.020109378,0.0008392231,0.005361563,-0.005765981,-0.042903334,-0.044046644,-0.040667653,-0.06935844,-0.038343087,0.043791108,-0.04597506,-0.041889872,0.08989461,-0.054606356,0.06913626,0.057482857,-0.0038172957,-0.019567823,0.053142164,-0.010788753,-0.04829072,0.012917228,0.024184134,-0.0041306634,-0.0338268,-0.03245404,0.003744687,-0.0034168267,-0.084161185,-0.0022707887,0.011282134,-0.00018460228,-0.11700422,0.025966804,0.028335482,-0.022062507,-0.062706605,0.025448525,0.09633563,0.035612803,-0.07572902,-0.035105426,-0.12463836,0.0037000075,-0.07312514,-0.02669283,-0.11397764,-0.12395313,-0.003149717,-0.025028082,0.16134958,0.025705954 +2.1.1.140,The enzyme is specific for the (S)-isomer of coclaurine. Norcoclaurine can also act as an acceptor.,384,1.0,-0.040550176,-0.03729459,-0.048293933,-0.04619272,-0.0018930867,-0.007394717,-0.05694607,-0.06399564,0.043401152,-0.056896765,0.0646803,-0.039974064,-0.09268494,0.069387786,-0.034476012,0.028810434,0.004980777,0.010913618,0.042141717,-0.014856033,0.054032367,0.06524116,-0.0124284495,0.028786385,0.008493077,-0.039252143,-0.040371105,-0.023047034,-0.0069478205,-0.06237516,0.014906056,-0.0628817,0.024790226,-0.014856015,-0.007977959,-0.017858267,-0.016941806,-0.019350788,0.020280827,0.0669065,0.018539537,-0.032314565,-0.04558408,0.03986438,-0.06648716,-0.019228593,-0.0342373,-0.026932862,0.0039104815,0.025395319,0.01655813,-0.024776,-0.07123308,0.015678365,-0.037483763,0.11514852,-0.051557496,0.044348054,-0.002353766,-0.038467653,0.06324997,-0.053868577,0.010211195,0.05867052,0.036157224,-0.008547515,0.016864782,-0.05047759,0.01603867,-0.07882551,0.0042227283,-0.10890334,-0.019759268,-0.05691026,0.024401534,0.0037560726,-0.040720772,-0.011884946,0.04967125,0.02700818,0.0019879749,0.014387864,-0.029134862,0.040066235,0.077507816,0.05043838,-0.04781145,-0.024014795,0.015922116,-0.0032705225,0.03434691,-0.12487982,0.0211714,-0.08929718,0.043806814,-0.026455509,0.03860534,0.05694866,0.008899454,-0.027986363,0.008993204,0.03461891,-0.12908465,-0.07806142,-0.056044698,0.08521963,-0.00728812,-0.02680809,0.011208007,0.011470696,-0.09070187,-0.01267467,0.099033035,0.006728278,-0.031899158,0.106343225,-0.008776721,-0.0042401976,0.056509305,-0.01646667,0.01949603,-0.05353883,-0.0021520029,0.0784561,-0.001074829,0.1379811,-0.05676799,-1.125576e-33,-0.005690012,0.045011967,0.025898298,-0.05285354,-0.057452288,-0.023350598,-0.04337122,0.05613695,-0.06856481,-0.07641903,-0.08344901,-0.0965412,0.049888343,0.055445854,-0.025291603,0.011887955,0.018345613,0.03831327,0.02086855,-0.038044848,0.029115656,0.117982745,-0.096114874,0.04405604,-0.03136983,-0.00090488035,-0.045434985,0.026445309,0.02289096,-0.029482745,0.05876898,-0.08364168,-0.019023778,0.023745261,0.0853378,0.05054973,0.011631278,0.002577583,-0.022426283,-0.033419527,-0.036514014,0.060880035,-0.06763013,0.00338843,0.10326708,-0.025620103,-0.054828998,0.08632263,0.0032246967,0.032354083,-0.00091917685,-0.005902741,-0.004602366,-0.023022603,0.002764545,0.06916772,-0.00051861553,-0.015213587,0.001601836,-0.04264987,-0.04122176,0.05013814,0.021662015,-0.046385348,0.0031661624,0.080250196,-0.079735875,-0.034895606,-0.0017815153,0.06383099,-0.03342399,0.021983717,-0.008046764,0.08624375,0.043002017,-0.02217661,-0.06767641,0.0006664118,0.07529359,-0.056752026,-0.024764469,-0.026621316,0.007136236,0.0037102336,-0.07680119,-0.06088911,-0.034974094,-0.07823532,-0.0016905634,0.02972016,0.142102,-0.025086498,-0.106640734,0.0067789447,0.02867804,-4.172032e-34,0.0870841,-0.09670827,0.028313233,-0.07724589,-0.029019382,0.104457155,0.015807798,-0.07817993,0.07340672,-0.0067573856,0.04528043,0.026291637,-0.010206622,-0.06338274,0.022947337,0.0018006238,-0.04009211,0.09659629,-0.017253626,0.048452836,-0.046441343,0.034744732,-0.00607746,0.0076505337,0.028398355,0.053383954,-0.019598644,0.080812395,0.07065707,0.046911374,-0.05376803,-0.016285852,-0.00041114478,-0.03176673,-0.0020730465,0.050736405,-0.070171334,0.05912444,-0.06662952,-0.06936759,-0.027101852,0.044784162,-0.011844492,0.050286237,0.047751077,0.01814768,0.003326173,0.0044021015,-0.04407584,-0.031759188,0.0069588907,0.022014817,-0.0016747997,-0.004001525,0.08358607,0.13155018,-0.0048642317,-0.09777446,0.0010685564,-0.060053904,-0.0025813354,-0.05548243,0.03049032,0.027236514,0.03144926,0.010010694,-0.017144313,0.10895328,0.006067146,-0.045733992,0.038574766,0.005110554,0.062407866,0.021669758,-0.025009219,-0.0938888,-0.055687796,-0.074874766,-0.0039640404,-0.02854602,-0.112375736,0.009130635,0.052100796,-0.030860193,0.03243845,-0.009856554,0.038149428,0.06639203,0.029553965,0.091235235,-0.027016679,0.012709065,-0.012545576,0.039618563,0.11674509,-2.7487896e-08,0.09274334,-0.044320095,0.08922879,-0.06604822,-0.037066966,0.04749181,0.025412057,-0.07756618,-0.04802722,0.01491826,-0.0052864216,0.09899276,-0.0005458398,-0.02564827,0.066301815,-0.011624291,0.013064046,0.0011503476,-0.050260074,-0.027507124,-0.08492594,0.05708834,-0.063406,-0.039913807,-0.016664652,-0.018751377,0.07283964,0.15355633,0.06345748,-0.023903089,-0.017307611,0.0149485255,0.013859914,-0.066123076,-0.04470052,0.05981118,0.0033143533,0.026564993,0.02107456,0.008368843,-0.0346286,-0.041457225,-0.04554538,0.026636498,0.067744866,0.022986593,0.06337926,-0.052757796,-0.034220543,0.06410257,0.020268017,-0.03625885,0.0014716488,-0.014678765,-0.065455556,0.018422497,-0.059887487,-0.016347641,-0.062168404,-0.063301586,0.021218998,0.022655774,0.19094296,-0.01393665 +2.1.1.141,"9,10-Dihydrojasmonic acid is a poor substrate for the enzyme. The enzyme does not convert 12-oxo-phytodienoic acid (a precursor of jasmonic acid), salicylic acid, benzoic acid, linolenic acid or cinnamic acid into their corresponding methyl esters. Enzyme activity is inhibited by the presence of divalent cations, e.g., Ca2+, Cu2+, Mg2+ and Zn2+.",384,1.0,-0.024915459,-0.06832908,-0.058510114,-0.016607938,0.11379416,0.06577705,-0.09649761,0.06431691,0.0031571048,-0.050050534,0.010032447,-0.025330387,-0.058530882,0.042327363,0.01380286,0.039335538,-0.015860151,0.0120529635,-0.04193404,-0.024058267,0.04358879,-0.018704355,-0.0071874857,-0.04590556,0.03333378,-0.045621842,0.071571395,-0.004414573,-0.024859875,-0.04395041,-0.010855512,-0.030521076,0.051613927,-0.0021354263,-0.040776793,0.032746863,-0.040762424,-0.07682528,0.006994931,0.049406815,0.00961059,0.038661987,-0.04370588,-0.055689555,-0.041282173,-0.103953876,0.005140381,-0.00929438,0.029977996,0.013236259,-0.11005924,-0.025681192,0.0065173786,0.0062007983,-0.0042199837,-0.04129507,-0.02234658,-0.014023528,-0.026744734,0.019671721,0.06511454,0.005005941,0.007766273,-0.021117888,0.00014481538,-0.036743876,0.018729111,-0.06573065,0.03048075,-0.024526272,-0.03409436,-0.056203812,-0.047592603,-0.054646704,-0.053738695,0.054741506,0.018460521,-0.04891269,0.03136597,-0.04888421,0.045736942,0.019008342,-0.03292513,0.04352759,0.007945129,0.031486288,0.000101433376,0.033480752,0.0498029,0.07576504,0.01946219,0.06326597,-0.08147373,-0.042571384,-0.121818155,0.05571703,0.040460765,0.005846443,-0.03284951,0.046394326,0.069739036,0.11460506,-0.002878046,-0.07772268,-0.083843455,0.046768393,-0.028472073,0.035912275,-0.08009133,0.003502012,0.07624219,-0.0021464813,-0.008648972,0.014891218,-0.018086607,0.078496315,0.03875923,-0.074018426,-0.10148492,0.014651104,0.0499899,-0.043992314,0.104811035,0.021402923,-0.03721179,0.03937609,-0.07545701,2.4566781e-33,0.026883738,-0.0063949893,-0.038043547,-0.058292627,-0.009510094,-0.022528782,-0.12996241,0.13132532,-0.051773813,-0.07454849,-0.0321014,0.009449673,0.022853076,-0.0003492042,0.002093904,-0.026681386,0.08338766,-0.03934189,0.052047446,0.033650536,-0.0097151175,0.011518368,-0.041957013,0.016371185,-0.0034988911,0.11711687,-0.04362445,0.0655504,0.009429708,-0.011504473,0.036814265,-0.08721993,-0.01341039,0.031796042,0.09339694,0.0109625235,-0.0012521085,0.016622763,0.017365802,-0.06672128,0.0010649358,0.012855999,0.0234839,0.05827491,0.0478559,-0.06423687,-0.03212995,0.059004053,0.038207453,0.0012891147,-0.016719637,0.031727865,0.08107845,-0.033914905,-0.05559999,-0.0010818787,0.027312176,-0.026939297,-0.007827123,0.020166658,0.01626137,-0.036540043,-0.034379985,0.074672885,-0.019645626,-0.016573647,-0.046261888,-0.02564502,0.039897025,0.039929964,-0.05313989,0.03404883,0.03868606,0.042498447,0.03381104,-0.05137083,0.010832566,0.033268444,0.084890984,0.0047068684,0.024032341,0.035996903,0.032854237,-0.0208722,-0.06282073,0.017252373,-0.10841585,0.035200592,-0.046825327,0.016768089,-0.007917645,-0.016708191,-0.01858331,-0.015532825,0.042345613,-5.0942064e-33,0.082968816,-0.06362657,-0.026250508,-0.06425245,-0.024963241,0.10959082,0.04324828,-0.0046696947,-0.054681614,-0.038246237,0.056171034,-0.02375848,0.056990944,-0.08126085,0.052842807,0.04599755,0.004405983,0.1591307,-0.05690694,-0.042089224,0.020830374,0.13391742,0.03066303,-0.005343426,0.038144376,-0.012609456,-0.0024452074,0.027552549,-0.013126395,0.12569182,0.020703724,0.022946954,-0.055162665,-0.059136953,-0.028627908,0.036006313,-0.03085769,-0.044920992,-0.036705673,0.10775859,0.0035380311,0.010089767,-0.01921616,-0.0044138846,-0.011798824,0.08432204,-0.07779811,-0.020739594,-0.027930185,-0.0002675459,0.06871998,0.0004243032,-0.05745178,0.032942068,0.0518643,0.10931151,0.00526338,-0.03039287,-0.03305614,-0.017064046,-0.090938784,-0.052188586,-0.0029820595,-0.04660573,-0.010527707,0.05200944,0.040330816,0.13090536,0.052128207,-0.07927102,0.08896242,0.043926556,0.015644707,0.04302113,-0.08424101,-0.005571886,-0.027464896,0.016796483,0.014237577,-0.027025513,0.040277075,0.009224209,0.009802259,-0.059453536,0.031560626,-0.1097658,0.009950036,0.036733072,-0.0062462864,0.06558248,0.01667448,0.034108326,-0.0619125,0.029595349,0.036011472,-4.3652857e-08,-0.037341084,-0.10223874,0.03851406,-0.08475888,0.009376462,-0.017061068,0.0047547403,-0.03890866,0.027091207,0.02972633,0.0037972203,0.03733617,-0.06465591,0.046038084,-0.043084625,-0.0404259,0.025147486,0.08196934,-0.035879448,0.029217238,-0.065091334,0.020558776,-0.08631373,0.006833044,0.03170839,-0.076581776,-0.077404805,0.006780974,-0.0018681118,-0.012984621,-0.027013207,0.027465122,-0.013930699,-0.035647757,-0.08179945,0.015011151,0.0410936,-0.054361716,-0.087794475,-0.019596495,0.02604252,-0.053797513,-0.10074507,0.020612475,0.014132657,-0.013275719,-0.047079474,0.0414159,0.020768728,0.051960584,0.048204374,0.042175088,-0.018650435,-0.060846083,-0.095706016,-0.058245245,0.05692673,-0.100797035,-0.09139442,-0.038175076,0.099264696,0.06784838,0.18472943,-0.074299306 +2.1.1.142,S-Adenosyl-L-methionine methylates the Si face of the 24(25)-double bond with elimination of a hydrogen atom from the pro-Z methyl group at C-25.,384,0.99999994,-0.04853351,0.045134377,-0.014709118,0.024634477,0.021629175,0.037315655,0.0089760125,0.03987985,-0.016005158,0.027821027,0.04991033,-0.03905095,-0.016024565,-0.020419052,0.03770307,0.0071165445,-0.10562468,-0.002914119,0.016094025,0.050374422,-0.00043819827,-0.03142998,-0.0039910204,-0.015200537,0.055364862,0.057771597,-0.013547416,0.030581279,0.018801885,-0.018443272,0.03305088,-0.013702103,0.0939295,-0.01502123,0.058976498,-0.018442899,-0.04993679,0.04357302,0.013559632,-0.0028711,0.017920252,-0.02832014,0.045711458,-0.044739053,0.012132966,-0.023924341,-0.054829564,0.028415626,-0.048682567,-0.041509755,0.03455353,-0.07885152,-0.040632993,0.025093615,0.026763722,0.08770995,-0.018383136,0.07499497,-0.011862798,-0.04628681,0.06139952,-0.06416893,-0.060344733,-0.032322492,-0.04013531,-0.031167261,0.066131845,-0.063640825,0.059942957,0.006917633,-0.015561385,-0.018818082,0.014198001,-0.0648348,-0.010154714,-0.060946908,0.047572725,-0.07720283,0.050364465,-0.019260347,0.005075254,0.020526597,0.050941847,-0.017815955,0.02841779,0.023574691,-0.0601453,0.00058723614,0.06747064,-0.06928752,-0.10044021,-0.03687485,-0.059750352,-0.08051849,-0.051907662,0.016917808,0.04376258,0.011664451,-0.029339664,0.079197004,0.06577342,0.06132568,-0.14805485,-0.055035856,-0.035352524,0.042999297,0.055272833,0.036779013,-0.09712871,0.029470285,0.045609638,0.040044755,0.032385543,-0.051902946,-0.03338879,0.022366745,0.04443257,0.04669854,0.056311645,-0.055568147,-0.039878875,-0.020920975,0.017740041,-0.06393507,-0.06251211,0.008182011,-0.080688246,-2.1484005e-33,0.016329322,0.10623966,-0.006978425,-0.015802793,-0.004170455,0.019636607,-0.027993105,0.027607763,-0.044441808,-0.07389447,-0.08986156,-0.12874392,0.04698322,-0.037054718,-0.09734283,0.04530698,0.017856054,0.00302042,-0.0131628085,-0.11349799,-0.057330042,0.0566819,-0.05654167,-0.051864643,-0.008024906,-0.06451375,0.028510632,-0.038381174,0.03762059,0.01479382,-0.09398706,0.107046425,-0.029424042,0.0443298,0.07900832,0.045182243,-0.09777442,-0.010043831,0.07935988,-0.01571906,0.06810513,0.07322116,-0.021623926,-0.040406603,0.028494194,0.038282093,-0.015318866,0.026704418,0.07223264,0.02265928,0.012304297,-0.044949494,-0.04102926,0.02390253,-0.14832358,0.013465218,-0.01610627,-0.07500034,-0.033577964,0.1049078,-0.004176451,-0.02412133,0.02901238,0.04458419,-0.00035812485,-0.005914101,-0.06599265,0.024931554,0.0128108,0.040204853,-0.005036474,0.03467604,0.1244326,-0.013566766,-0.060650557,-0.012002337,0.03327405,-0.0033228938,0.049666755,0.057830147,0.056582715,0.039968997,-0.0013373846,-0.06565585,-0.049994953,-0.008913918,-0.0006136506,-0.04407229,0.03572782,0.063212804,-5.442132e-05,-0.1840667,0.023324931,-0.018329082,-0.07569705,2.6045633e-34,0.007150409,0.04979572,0.012142979,-0.09062175,0.01916238,-0.022265647,0.05272074,-0.098936,-0.040974837,-0.029427323,0.16652979,0.006768493,-0.005662217,-0.014546264,0.025904551,0.03083764,0.029184183,0.02020877,0.040574174,0.0021136568,0.06562441,-0.05256333,-0.057845064,0.07287701,0.05291009,-0.0051977173,0.060489517,0.0034413931,0.0845433,0.080360875,0.024607802,-0.05705222,0.014900715,-0.02819812,0.03602615,0.07378935,-0.021651834,-0.019260397,-0.04319678,-0.026857112,-0.019241275,-0.014474242,0.02445183,0.11554995,0.03786017,0.060721114,-0.045116954,-0.059189267,-0.052997265,-0.05964514,0.010330172,-0.12884362,-0.047393907,-0.028954027,-0.04040798,0.052210055,-0.015989013,0.07496346,-0.063957065,-0.027194835,0.025314631,-0.03551548,-0.016094564,-0.031318452,0.019338896,-0.029277142,0.027292939,-0.016931098,0.041609712,-0.048929118,-0.016402882,0.041954342,0.019216994,-0.011629767,-0.08360898,-0.07668047,0.012595635,-0.011013733,-0.0018181823,-0.013748213,0.01026496,-0.01703771,0.0037541536,0.0017122112,0.00924618,-0.021245975,-0.001954224,0.07519569,-0.043141037,0.08959312,-0.08751923,0.08030796,0.008137243,0.066203915,0.033934806,-3.0390694e-08,0.083103985,-0.14226161,-0.04980524,-0.016433286,-0.08752253,0.06404116,-0.022015214,-0.0327347,0.026207771,-0.01209968,-0.0063141817,0.048534412,0.019442579,0.007050446,-0.013995968,0.017250113,-0.090042405,0.071449876,-0.060693976,-0.01117229,-0.053649835,0.057539634,-0.020516025,-0.019625086,0.013360122,-0.006294594,-0.0059584435,0.12577061,-0.044537175,-0.017327363,0.10478714,-0.060309105,0.026078302,0.09048019,0.051870685,0.024520202,0.012880785,-0.029104218,-0.0019482962,0.015094155,0.071888044,0.02119718,-0.009584986,0.1140605,0.016153455,-0.027937697,-0.05265122,0.104217015,-0.033100713,0.061711535,-0.030548904,0.036044195,-0.04381575,0.0036970472,-0.0305556,-0.009637702,-0.009873006,0.023252282,0.016106924,0.011919191,0.068683945,-0.01099719,0.06714917,0.023657652 +2.1.1.143,"This is the second methylation step of plant sterol biosynthesis (cf EC 2.1.1.142, cycloartenol 24-C-methyltransferase).",384,1.0,-0.042296324,0.076171,-0.12869199,0.001125335,0.0025860935,0.04897641,-0.09434508,0.034392145,0.050067768,-0.06774173,0.1268231,-0.053373314,-0.06212829,-0.13303305,-0.02867321,0.03682996,-0.11479767,0.017157845,-0.02980005,-0.019384334,0.05419906,0.066728234,-0.03344038,-0.007850026,0.020129267,0.043512616,-0.089306846,0.050409894,0.07866539,-0.01597452,-0.0141970655,0.07748464,0.07385107,-0.022604538,0.014323438,0.06355655,0.02159044,-0.07041752,0.025496399,0.05540455,0.06406237,-0.05995739,0.016309518,-0.010315856,-0.025906568,0.010186599,-0.00029170307,0.0013686898,-0.027297359,-0.07952698,0.041620508,-0.08234992,0.008837922,0.013258149,-0.00013506532,0.050998155,-0.0027104216,0.0022453016,0.0015975437,-0.01068206,0.058015678,0.0067440984,-0.11035851,0.0011485245,-0.036067538,-0.037761834,-0.0056396243,-0.11501003,0.061195917,-0.021263497,-0.07442146,-0.063558124,-0.024528708,0.070912644,-0.046716414,0.033366073,0.010413051,-0.030121334,0.0210088,-0.06669034,0.09871181,0.049114473,-0.030006064,-0.022297801,0.0018748969,0.0034203047,-0.04485198,0.023001952,0.019235509,0.073405616,0.027011419,-0.013022172,0.040124614,0.05464317,-0.086562485,0.088556156,0.06781806,0.025246238,0.03769752,-0.030550499,0.012988427,0.07664952,-0.056871153,-0.005617575,0.009378073,-0.040459774,-0.014221273,0.06966075,-0.035524383,-0.009339513,-0.017338557,-0.015709255,0.018978326,-0.026822103,0.0018957224,0.124471076,0.031801257,-0.00606006,0.0034744404,-0.013549025,0.013539427,-0.0082261395,-0.021494651,-0.013045322,-0.028569592,-0.02100108,-0.07482015,-1.7232298e-34,0.08909812,0.060320575,0.03413389,0.01932952,0.013337302,-0.0096093705,-0.003148442,-0.027960615,-0.008361024,-0.09312054,-0.04115628,-0.15844259,-0.018033314,0.017116377,-0.08898748,-0.050946686,-0.011906142,0.00451814,0.06002294,-0.06670784,-0.020130355,0.08437007,-0.0576343,-0.08861448,0.007886201,-0.046565726,0.002713497,-0.05924457,0.060333893,0.0061506527,0.012993241,-0.0637019,-0.033239827,-0.035424493,0.079059534,-0.009302932,0.0234018,-0.056364696,-0.009380668,0.108600505,-1.4542514e-05,0.021646991,0.017415779,0.026189884,0.03731431,0.038627557,-0.09259104,0.060630936,0.12831262,0.060251355,0.015542711,0.04363145,0.046118714,0.01389296,-0.029220061,0.024231104,-0.018829742,0.013394836,-0.09810026,0.030858546,-0.033163477,0.077899046,-0.0388962,0.054704305,-0.025482286,-0.037117206,-0.10855017,-0.054428052,-0.035839558,0.05380935,-0.05811669,-0.101430394,0.054494567,0.005188634,0.09963961,0.03145721,-0.0277221,-0.002203589,-0.03087804,0.00016732188,-0.11496606,0.058298584,-0.042031422,-0.031762518,-0.02978612,0.03485079,-0.0209701,-0.05066521,-0.008513445,0.0352635,-0.014879807,-0.011961658,-0.026094954,0.016961891,-0.0043349247,-1.7035117e-33,0.029496264,-0.011013548,0.024638833,-0.06308654,-0.012413766,-0.008242766,-0.05774531,-0.019696005,0.023135148,0.004338248,0.07371793,0.060603958,0.033541545,0.009722484,-0.0017734756,-0.00090745726,-0.0010301053,0.049137644,-0.03458885,0.05026547,-0.014982471,0.006391601,0.024382407,0.130816,-0.008452673,-0.009519978,0.06755321,0.010043449,0.08472098,0.019435734,0.015003524,-0.051833693,-0.026151791,0.029029783,-0.033126876,0.02834386,-0.03059617,-0.036835935,-0.026078006,0.04708789,-0.055820983,-0.0050559924,-0.024452806,-0.013896242,0.03285518,-0.00484248,0.0072031836,-0.0038533343,-0.011844066,-0.0320383,0.02650204,0.035699062,-0.03884466,0.14955135,0.042490404,0.0019827983,0.028076421,0.070482455,0.056787856,-0.054596793,0.022534177,0.01924015,-0.053605642,-0.074325494,0.06488559,0.055428125,-0.00066758227,0.023186484,0.0005558721,0.033212826,0.035201732,0.05121763,-0.0169492,0.051512077,-0.08592856,-0.058969688,-0.03411693,-0.085668825,-0.1125264,-0.006515562,-0.033860423,-0.021363229,0.070233844,-0.0460809,-0.09469917,-0.063963875,0.028413596,0.07759849,-0.015176908,0.026968187,-0.021182615,0.019928217,-0.08283547,0.10501511,0.01305122,-2.7946056e-08,-0.029176977,-0.110563196,-0.011155305,-0.074028075,-0.04131602,0.017683113,-0.0061301677,-0.03780829,0.046668574,-0.0027120272,-0.04364299,0.07643506,0.05958115,0.011412815,0.026185004,0.0069365427,-0.018084241,0.013697124,0.028920298,-0.07422651,-0.078606345,-0.0030781925,-0.0016792958,-0.030377414,-0.0069883815,-0.036945913,0.07943619,0.13273105,0.046780314,-0.026348336,0.1211937,0.038981207,0.034730162,0.04255833,-0.014758652,0.073938295,-0.0011243963,-0.08983097,-0.003550623,0.05515256,-0.003589626,-0.03515188,-0.02510938,0.072838716,0.0245183,-0.021894813,0.017446948,0.121376604,-0.0017561655,-0.049052503,0.012669357,-0.02584693,0.01805493,-0.029292632,-0.03666514,-0.019703856,-0.03846421,-0.016837249,-0.0024018942,0.010867504,-0.0037662257,0.023261944,0.1703016,-0.007829059 +2.1.1.144,"Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145, trans-aconitate 3-methyltransferase).",384,1.0,-0.07080365,-0.068935394,-0.07092161,0.02897167,0.03430862,-0.014351272,-0.08622323,0.09825495,0.055026438,-0.041593947,0.041954167,-0.10000168,-0.075248554,-0.00852696,0.0050826436,-0.015020617,-0.061681665,0.0015881362,0.04138603,-0.050813552,0.10769998,0.017016431,-0.012882976,-0.013922544,0.039504472,-0.0008970945,0.019958062,-0.04057311,0.0052952436,-0.04639965,-0.026178166,-0.05842565,0.016220216,-0.029343583,0.06361508,0.03298311,0.047528796,-0.078317456,0.07360222,0.0068727415,0.017939582,0.011033319,-0.026709089,-0.009728871,0.00012688065,-0.023165222,0.02685856,-0.013639481,-0.018371006,-0.06912145,-0.036154024,-0.061630864,-0.055098336,0.005600585,0.02143382,-0.03079295,0.07998135,-0.018040579,-0.048425764,-0.0010135819,0.05785292,-0.013995648,-0.0027230412,0.0056478414,0.00789852,-0.083428875,0.097419,-0.052162904,0.02732039,-0.033189155,-0.07601994,-0.027391786,-0.11323783,0.052760933,0.03512917,0.032380708,-0.0068138624,-0.016948901,-0.005122748,-0.0015561343,0.039797187,0.07563347,0.040369794,-0.012348441,0.051493593,-0.029186822,0.001244494,0.08545285,0.08167273,0.050511096,-0.09011081,0.050921317,-0.028904432,-0.012464003,-0.052746788,0.013995756,-0.011329145,0.094947025,0.019109225,-0.009886059,0.002873897,0.11478172,-0.09214221,-0.047572754,0.0037477151,0.011396152,0.04179947,0.08643151,0.015459841,0.04331609,-0.031116992,-0.05174322,0.03286419,-0.010752852,-0.069772206,0.111339755,-0.003016853,-0.028439928,0.060299605,0.05732156,0.016817583,-0.008407289,0.050784234,0.03629074,-0.04057954,0.005702353,-0.05926719,1.2748378e-33,0.01529706,0.031929042,-0.026210202,0.030024698,-0.015144042,0.08829499,-0.09594298,0.034052655,-0.05348798,-0.07475606,-0.030556258,-0.080336615,0.04021013,0.093180515,-0.008644364,-0.04170066,0.0152761815,0.050335106,0.024695225,-0.02510304,0.0056067524,0.021240888,-0.046354786,-0.014423193,-0.0056954585,-0.03681185,-0.048899695,0.054542776,0.018083222,-0.03046875,-0.033000108,-0.071775384,-0.05344261,0.011864856,0.050559144,0.007654825,0.010975603,-0.044984017,0.015347894,0.106760174,0.08301102,0.03193422,0.036407273,-0.06360208,0.067176454,-0.012070043,-0.08994947,0.051636174,0.058944594,0.050692994,-0.0023381244,0.019872677,0.074488066,-0.03426447,-0.044956326,0.045185406,-0.004764042,-0.006735733,0.011774916,-6.3075975e-05,-0.06530264,0.096104816,-0.02967262,0.06610317,-0.07498251,0.041395772,-0.06308058,0.014528238,0.003962057,0.1016456,-0.06869989,-0.018909903,0.02886266,-0.013829371,0.062141668,-0.11877997,-0.12242168,-0.026209187,0.01596139,0.0148016205,-0.009840761,0.015612615,-0.026110977,-0.076419614,-0.06881408,-0.003740806,-0.057180494,0.046572626,-0.00971633,0.052990362,-0.002776549,-0.02399672,-0.06748411,0.04110235,0.07421037,-3.4577725e-33,0.06856103,-0.020410324,0.023205152,-0.15651684,-0.108046845,0.06639514,-0.0265216,-0.033536226,-0.0077441633,-0.00814464,0.066999406,-0.0490074,0.049190734,-0.055744063,-0.011355111,-0.03232741,-0.038083468,0.053030487,0.06924807,0.006625111,0.025470441,0.004800402,-0.054141954,0.057630874,0.045661557,-0.0029044016,0.0021781314,0.10631393,0.041396607,0.012973655,-0.039362624,-0.06953598,-0.021683216,0.015147584,-0.092123,0.07424721,-0.020972107,-0.024887597,-0.00044262767,0.037799913,-0.014715716,0.042617682,-0.012727004,0.08182121,-0.0032789244,0.08838359,-0.04828673,-0.016682591,0.02378896,-0.06749217,0.022657733,-0.037464567,-0.02389348,0.0050520906,0.021543387,0.03837253,-0.04820608,0.004601821,-0.050929543,-0.031242838,-0.004119039,-0.00878459,0.003904968,-0.031930655,0.08138941,-0.016770083,-0.05010587,0.009804457,0.061448574,0.008195646,0.056703422,0.06291659,-0.0325138,-0.008686628,-0.021037346,-0.063317075,-0.055735547,-0.05971704,-0.020326743,-0.060273122,0.004255846,-0.06626458,0.008690331,-0.03430492,-0.080955215,-0.06998503,-0.0010552948,0.05732555,-0.03388151,0.070350446,-0.03617384,0.031607714,0.034341,0.103999436,0.06743197,-4.5950483e-08,0.060762845,-0.09045608,0.04437381,-0.03438811,-0.03318326,0.02993926,0.028966136,-0.04721038,0.04988461,0.001956393,-0.073224686,-5.212153e-05,0.048674654,0.03650734,0.0472885,0.029306803,-0.014470567,0.01386949,0.012269583,0.06223691,-0.07136978,-0.023856297,-0.04775394,0.020050207,-0.034707714,-0.011235466,0.052593175,0.0820651,-0.012490896,0.041722063,-0.0602064,0.002643495,0.017107168,0.016323417,-0.09795359,-0.014008991,-0.011654801,-0.063429534,-0.04196852,0.031508338,0.08136527,0.022169158,-0.11825529,0.0257928,0.06397809,-0.0017614891,0.021194458,0.044656754,-0.047412395,-0.03688482,0.057551865,0.0014460532,0.01349525,-0.013838418,-0.0614415,0.01714085,-0.0863214,-0.027201172,-0.009841783,0.010630026,0.042869624,-0.027543258,0.2706735,-0.01587251 +2.1.1.145,"Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase)",384,0.99999994,-0.059892874,-0.07138007,-0.06807176,0.0329839,0.038716927,-0.01829846,-0.09469517,0.10207583,0.054955754,-0.04482259,0.04201294,-0.09776956,-0.07830155,-0.013256496,-0.017227177,-0.010828081,-0.056571547,-0.0050982847,0.05229607,-0.04643479,0.10611803,0.018833179,-0.015065713,-0.02178394,0.042687755,-0.005526844,0.0067410097,-0.037508756,0.010149997,-0.053003583,-0.022333035,-0.059810083,0.015342166,-0.012869404,0.04851257,0.040622655,0.06309245,-0.074724324,0.07293988,-0.0042533763,0.018781725,-0.0012904044,-0.038809687,0.005982456,0.001951697,-0.014287875,0.029437536,-0.01317279,-0.019385748,-0.064776,-0.04692682,-0.057231355,-0.0502334,0.010747725,0.012186892,-0.015335027,0.073152915,-0.016650181,-0.039232366,-0.00684001,0.038865644,-0.024107857,0.0012534516,0.01031175,-0.001580914,-0.08228255,0.09366352,-0.039754685,0.029509079,-0.033429533,-0.08108945,-0.024773207,-0.09993561,0.04653603,0.04241471,0.021297624,-0.00076201325,-0.015571675,0.009032933,-0.0069219265,0.041010454,0.07673938,0.043210167,-0.02369673,0.04700605,-0.029564569,0.009563315,0.08051294,0.087783284,0.04284719,-0.08077027,0.055865612,-0.015713187,-0.013534689,-0.04904342,0.010965824,-0.0068717026,0.1040068,0.022423424,-0.022280112,0.0056371624,0.11170368,-0.082028635,-0.05118621,0.0034424965,0.0057374574,0.03374715,0.07811028,0.027882865,0.04134154,-0.023371693,-0.033499602,0.01620209,-0.010369709,-0.05523485,0.10246276,-0.010431212,-0.021214973,0.05696939,0.04790287,0.008887823,-0.006432123,0.043026477,0.034924954,-0.044613685,0.00046143966,-0.066275194,1.8254896e-33,0.009768944,0.038827255,-0.039163806,0.023316998,-0.007763503,0.077592455,-0.09720733,0.044377334,-0.054807942,-0.065621406,-0.035712626,-0.08531813,0.029583711,0.09451322,-0.0021878472,-0.053347215,0.033631377,0.036863532,0.03875898,-0.029990083,0.0019369589,0.028541632,-0.046396628,-0.012463853,0.008137199,-0.03209445,-0.04211681,0.054827593,0.009765147,-0.026443014,-0.042182982,-0.08353643,-0.04860324,0.02230279,0.059556723,0.015506175,0.008239589,-0.03833165,0.016103704,0.091212645,0.07467392,0.027520679,0.025970846,-0.06351762,0.070570655,-0.021557529,-0.09576381,0.05250875,0.06281151,0.058745425,-0.021222912,0.013774908,0.09054533,-0.033007186,-0.0492676,0.049841,-0.015326369,-0.012604732,0.004082852,-0.0062555475,-0.07048459,0.0937494,-0.028186021,0.071307614,-0.07944446,0.041095436,-0.070712,0.011339532,0.004860397,0.105806686,-0.066583715,-0.009437349,0.03032808,-0.017951997,0.06402913,-0.11400792,-0.11698737,-0.025606696,0.020264102,0.026801607,-0.011967895,0.016287291,-0.033115484,-0.07508698,-0.07632248,0.009775926,-0.05536697,0.050522093,-0.01824355,0.04729848,-0.011207934,-0.0269183,-0.057468686,0.030990884,0.08664969,-4.147088e-33,0.079896696,-0.010707125,0.031485617,-0.15622309,-0.108343005,0.069599755,-0.015749129,-0.03849733,-0.023070404,-0.012490962,0.060635887,-0.047400694,0.04071574,-0.060558982,-0.015903678,-0.020847894,-0.037731927,0.061391436,0.06995508,0.008753913,0.03167128,0.026741713,-0.058557663,0.053370867,0.044155996,-0.007133008,0.007852826,0.11552517,0.047626343,0.004509675,-0.044075616,-0.055386115,-0.013131415,-0.0019631754,-0.08096937,0.064462155,-0.035892736,-0.016582312,-0.010795078,0.04959485,-0.008943588,0.047704615,-0.02739191,0.07935671,-0.0014197781,0.08695535,-0.042203236,-0.017874144,0.025225667,-0.08460133,0.021623382,-0.03081322,-0.034757312,0.012062841,0.027859349,0.04065813,-0.04954657,0.011675644,-0.0505902,-0.047677636,-0.0050809165,-0.028091738,-0.0004064387,-0.030651541,0.091154985,-0.022390071,-0.048521366,-0.0036043685,0.048122883,0.013688728,0.054278467,0.059366737,-0.029735573,-0.011112245,-0.03710064,-0.06697756,-0.058453906,-0.0665261,-0.02406887,-0.061289605,0.0080701,-0.07332812,0.01965621,-0.02874032,-0.08644078,-0.07110513,0.0049557523,0.046732254,-0.035766207,0.08043717,-0.03581628,0.037087124,0.03167168,0.09441092,0.056626093,-4.7582876e-08,0.062513255,-0.08575031,0.050602455,-0.046285532,-0.017733665,0.038747255,0.021120852,-0.048550382,0.039772823,0.010922082,-0.09276158,0.0050946535,0.054457948,0.040529598,0.045277316,0.03127413,-0.012948898,0.020826947,0.018711053,0.0729142,-0.06515197,-0.02991804,-0.05850667,0.02837954,-0.03624547,-0.01880431,0.056801558,0.08215491,-0.005472489,0.038830694,-0.06335258,0.017591689,0.021390026,0.0047661206,-0.097003944,-0.0068904613,-0.004741161,-0.07100195,-0.043693624,0.031034222,0.081949584,0.015271684,-0.10054566,0.03942808,0.062977724,-0.009279357,0.03247688,0.033946376,-0.037228208,-0.028718255,0.06408412,0.006131289,0.00485052,-0.01828014,-0.059973948,0.012657743,-0.08518321,-0.030878507,-0.016246064,0.0055166204,0.051063426,-0.024207644,0.2616229,-0.04072399 +2.1.1.146,Acts on eugenol and chavicol as well as isoeugenol.,384,0.99999994,-0.0014004469,-0.013988475,-0.00760792,-0.015543253,-0.038831964,0.06198078,0.0011048792,-0.040940348,-0.0006676608,-0.030899499,0.11305604,-0.023020487,-0.0611795,-0.014488369,-0.021585511,-0.01605999,-0.034333806,0.11082993,-0.03058608,0.012266055,-0.012398911,-0.056490097,0.029104287,0.054214135,-0.08266593,-0.029934915,0.034117118,-0.014494672,0.02416416,-0.09268492,0.06377219,0.011715832,0.054233942,-0.046412613,-0.061522104,0.038296286,0.028783184,0.017473904,0.048262816,-0.014632796,-0.023388296,-0.09717402,-0.06376916,0.026970338,-0.014429914,-0.09860645,-0.04708161,0.041963194,-0.036962774,0.0151926,-0.028990623,-0.038159724,-0.023926558,-0.010742915,-0.060418885,-0.005795543,-0.035195287,-0.019329524,0.010669496,-0.01983582,-0.05970137,0.053244576,-0.10917418,0.070558645,-0.040492676,0.015228926,0.043933004,0.047971707,-0.019205198,0.02701237,0.05031466,-0.14259143,0.040829375,0.0038623204,-0.074103944,0.035440825,-0.01577947,-0.011483604,-0.053145923,-0.13708238,-0.051163822,0.05996817,0.011928582,-0.017250251,0.04305641,-0.03591959,0.012127375,-0.0869904,0.059384525,0.057808038,0.030481413,-0.04005604,0.01523015,-0.029010471,0.06365913,0.04872512,-0.012858079,0.0124890795,0.023812138,0.036039524,-0.037321962,0.019628037,-0.13902293,0.049152315,-0.025279379,-0.012599875,-0.052672975,-0.14029741,-0.0032688982,0.00011839185,-0.09114328,-0.059047904,0.00781429,0.0061757998,0.045209005,0.008732867,0.06544642,-0.043873485,0.024164349,-0.05233228,0.042342026,-0.028848846,-0.01695699,0.018358734,-0.032098718,0.002693412,0.031274233,-9.087849e-34,-0.04130223,-0.07939903,-0.017933138,0.084510066,-0.04255159,0.016954217,-0.07090975,0.035767667,-0.055683043,-0.037071038,-0.08000913,0.00740949,-0.041704424,0.07050178,-0.012352763,0.06731986,-0.045774926,0.07173211,0.03365303,-0.041911066,-0.039318927,0.15924545,-0.0200815,-0.017146854,-0.01025764,0.052030433,0.0072549023,-0.0608122,-0.024231117,0.057522513,0.014561369,-0.06853644,-0.021297494,0.0731121,-0.05049211,0.16673656,-0.09578821,-0.053095352,-0.051058087,0.04521527,0.00518562,0.019267866,-0.037471354,-0.015882993,0.014707275,-0.0010479222,0.06437778,-0.030274607,0.06756615,0.05139045,0.0333785,0.0301657,-0.0027236124,-0.08185941,-0.0076972605,0.05738562,-0.060540494,0.08447548,0.044438418,-0.028290113,0.02599933,0.07993737,0.015580394,-0.03542713,0.058524463,0.051191192,-0.07956625,-0.0064577907,0.029106708,-0.028141355,-0.08329983,0.011501681,-0.02486445,0.041864138,0.041448954,0.030808542,0.031744327,-0.04527599,-0.0016411695,-0.03265587,-0.12033699,-0.00871495,0.019121684,-0.00731499,0.019869838,-0.008127711,0.011145427,0.06462102,0.011190227,0.05213692,0.038671717,-0.027031807,0.02696695,0.03362401,-0.075753875,-3.1430375e-33,-0.07884141,-0.10164111,-0.031654213,0.027756315,-0.03079383,0.06619702,-0.13551033,0.020770373,-0.037064582,0.04937317,0.017245555,-0.007243366,0.06379834,-0.00271424,-0.056647886,0.012836204,0.04999628,0.03912235,-0.08270804,0.025996951,-0.048064787,0.12760516,0.009217254,0.07844512,-0.053235985,0.037034035,0.08333816,-0.0091245435,-0.0007718028,0.0406202,0.049999215,0.030797819,-0.049828913,-0.029699123,0.05467605,0.08228065,0.026161509,0.055754296,-0.056617096,-0.011471608,-0.10125127,-0.0066873706,-0.028227203,0.040293038,0.07156736,0.019154297,-0.015452547,-0.03479971,-0.076853424,0.009586198,0.021567866,0.08642117,-0.0032535961,0.010580046,0.026133284,-0.03369821,-0.012300094,-0.12603877,-0.0040033762,0.0094816955,-0.008450039,0.027324963,-0.03632637,-0.017833903,0.09592585,0.023348095,-0.11787373,0.04378683,-0.040800232,0.045153067,0.08188035,-0.055715974,-0.0616177,-0.027435984,-0.011574073,-0.06485464,0.058786593,-0.07215403,-0.049897105,-0.0049796985,-0.043723825,-0.08029396,0.01717226,0.016500058,-0.10535771,-0.028106513,-0.045589495,-0.0041683796,0.05539825,0.064182654,0.020329326,-0.035058897,-0.02702463,-0.00262881,0.09684245,-2.3134291e-08,0.025925407,-0.0026465587,0.06243192,0.009692589,-0.025463058,0.001818082,-0.09310801,0.0024155702,-0.027422523,0.11343101,-0.042278923,0.1180706,0.00986405,0.024652364,0.045606196,0.035689924,0.03155956,0.026900096,-0.050699763,-0.014039242,-0.02377422,0.04062971,0.041205637,-0.112062715,0.008417622,-0.053885654,0.024681883,-0.024109907,0.019639855,0.0063623525,0.0571996,0.06697408,-0.0636088,0.019474866,0.001452129,0.049750444,0.04926719,-0.03120939,0.03692971,0.047116864,0.03286903,-0.022899557,0.008869562,0.020047493,0.024593035,0.038407106,0.04743607,0.022347277,-0.012252167,-0.012121242,0.011946569,0.03545983,0.03728133,-0.022673447,-0.0023532033,-0.009319206,0.0033699248,-0.025729764,0.025229104,-0.030657297,0.06314301,-0.007716261,0.150665,-0.019289602 +2.1.1.147,"Also acts on 7,8-dihydropalmatine.",384,1.0,-0.07890302,-0.1480927,0.056472648,0.02641009,-0.0014250242,0.0046896543,0.080708854,0.061644398,0.0032365865,-0.023018716,0.009045244,-0.017896894,-0.10653641,0.10904344,-0.01974706,0.035236202,-0.060475223,-0.03947836,-0.047031526,-0.004114534,0.044055797,-0.006961011,0.009728196,0.021900693,-0.0053839576,0.06367061,0.0613695,0.0015989343,0.008868607,-0.13256946,0.01769677,0.09487766,0.009632324,-0.016579619,-0.005155024,0.03809193,-0.0040487237,0.01882942,0.027120134,0.054747034,0.054697458,-0.039319273,0.058881827,-0.0014782253,-0.05480371,-0.04301414,0.036410738,0.06556857,0.0702827,0.08944848,-0.020808304,-0.00466688,-0.016366089,0.09956438,0.018476587,0.0033300961,-0.0867579,-0.022038449,0.0029209533,0.009572237,-0.010721441,0.024579974,-0.010344823,0.0121663185,0.000972357,-0.01882131,0.021286923,-0.09122725,-0.037285432,-0.037055567,0.05752256,-0.0037001872,0.043880515,0.09267792,-0.010254187,0.044122595,-0.052889816,-0.072124034,0.0061848788,0.022855315,0.0020953342,-0.020849874,0.06890044,0.05773908,0.022953788,-0.022900455,-0.04011461,0.010581013,-0.05440425,-0.06602949,0.04523431,0.00017484755,0.0038594294,-0.005247128,-0.054376777,0.023136843,-0.008592892,0.010969081,-0.05389353,0.04912004,0.026246015,-0.021311063,-0.076415874,0.013239889,-0.030707119,-0.032369714,0.026433596,-0.032903228,-0.07280843,-0.056562662,0.010282609,-0.02811523,0.08435065,0.054422636,-0.05645477,0.030331513,0.022776134,0.0022572854,0.0019259269,0.0016075297,-0.0157601,-0.014252676,0.041476678,0.076754436,-0.09445926,0.08852364,-0.08806319,-8.539402e-34,0.01925443,-0.050328434,0.075022295,-0.03351097,0.007879815,-0.0808804,-0.06523561,-0.023888405,0.01351653,-0.033278137,-0.059635494,-0.015305056,0.07948542,-0.011415396,-0.043952074,-0.05003085,0.04539185,0.01530674,-0.039080083,-0.09190924,0.027295094,0.13138227,-0.10576613,0.016019972,-0.006757495,0.12247238,-0.020299563,0.08052863,0.14425802,-0.024801888,-0.009578952,0.005574627,0.0021679727,0.024171244,0.0014550649,0.083608195,-0.06608804,-0.0015218252,-0.0022048624,0.032159984,0.06338789,-0.0010833534,-0.053378914,-0.025057143,0.056537967,-0.038407482,-0.048661556,0.03508516,0.029725794,-0.025820397,0.09757694,-0.009328109,0.03449931,-0.014046337,-0.0045253756,0.0052332436,0.028157618,0.0038168076,0.08652682,0.07326586,0.041408055,0.014348922,0.003992415,-0.062244184,-0.057886817,-0.0028656416,-0.078037284,-0.051859807,-0.045551218,0.057804987,-0.080567665,0.051556874,0.101802185,0.013047972,0.060644872,-0.060176175,-0.056321193,-0.058681518,-0.015432971,0.022098398,0.011497492,-0.069624946,0.036139462,0.0052688597,-0.066322744,-0.045633666,-0.029478112,-0.105577864,-0.06843316,-0.050508335,0.051302694,-0.083353154,-0.043401767,-0.068608545,0.0006243847,-6.697544e-34,-0.06860091,-0.061355963,-0.028655965,0.09250577,0.045923498,0.059691496,0.06546405,0.050559707,0.018884625,-0.01196888,0.07360842,0.054946534,-0.050549317,-0.0147997225,0.042271316,0.10468089,0.0012282904,0.08407761,0.024312306,-0.043762803,-0.021383245,0.041077405,-0.024510404,0.11589026,-0.014485672,0.017817331,0.04068554,-0.061313275,0.08926825,0.07139957,-0.050957937,-0.021318436,-0.0688291,-0.029058654,-0.07804536,-0.028585063,-0.02914673,-0.063331984,-0.11593727,-0.071111865,-0.08491944,-0.091823235,0.10542809,0.124013215,0.00030551365,0.044748902,0.029547643,0.046203513,-0.057842128,0.06255215,-0.0011827367,-0.030110002,-0.038356084,0.0072639105,0.005811197,0.03435197,0.0077478,-0.04496581,-0.025585696,0.04851349,0.01564882,-0.059785884,-0.038033817,-0.07505675,0.052725684,0.05171395,-0.108406454,0.099359035,0.016155029,-0.051964894,0.081706464,-0.024101688,-0.010987918,0.01880246,-0.0012774324,-0.084681794,0.029825544,-0.0046492955,0.02104001,0.028932216,-0.06164694,-0.059432212,-0.057426184,-0.0046365275,0.014571052,-0.0010280223,0.040735014,0.03686622,-0.0015324239,0.09196786,-0.009380568,-0.012228249,-0.025080228,0.038910884,-0.007306636,-1.847225e-08,0.05486034,-0.09531306,0.0152702965,-0.04339171,0.018977782,0.020761382,0.066141784,0.048310187,0.02407928,-0.035741042,0.0399745,0.0058082812,0.042701986,0.059598852,0.08205244,-0.01776305,0.043644894,0.013963496,-0.07075796,-0.012328347,-0.054529708,-0.018912323,0.03297694,-0.011290607,-0.018164676,-0.022345345,-0.027092014,0.09722144,-0.022773648,-0.013583963,0.050195068,0.0076524336,-0.02993024,-0.068883754,-0.07819896,0.06914732,0.02203071,0.03197431,0.01416428,0.034620553,-0.012466135,-0.023303842,-0.058241464,0.025235526,-0.03556194,-0.048137777,-0.03559533,-0.028978404,0.06385444,0.02349181,0.024258712,0.052691247,-0.00066281814,-0.028617093,-0.048568543,0.010818737,-0.038014695,-0.035514217,0.01553601,-0.034860503,0.06658463,-0.035431,0.088932104,0.07492552 +2.1.1.148,"Contains FAD. All thymidylate synthases catalyse a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5 position of dUMP and a two electron reduction of the methylene group to a methyl group. Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin cofactor as a source of reducing equivalents, which are derived from NADPH.",384,1.0,-0.05087109,0.018513871,-0.07502704,-0.056598753,0.1576177,0.065491274,-0.08035475,0.03403179,0.015675256,0.022074305,0.0052650925,-0.034467157,-0.03746279,-0.06498604,-0.04023008,-0.0039419946,-0.12554805,0.021110438,-0.051070347,-0.10692026,-0.06325935,-0.011284324,0.046807636,-0.011197305,0.0030437638,-0.010072486,-0.007930797,-0.081850305,0.0027239057,-0.065205686,-0.030728294,0.019960243,-0.027576387,-0.08026964,-0.043649282,0.119148634,0.037070397,0.0025033427,0.055208407,-0.019683823,0.020180311,-0.062055163,0.0097566275,-0.069105715,-0.04235839,0.025264954,0.01914891,0.0272552,-0.016971346,0.0040409206,-0.060315605,0.0038942362,-0.058903113,0.018521745,-0.062282372,0.03820293,0.024552694,0.0055441833,0.0072793905,0.037618,0.017236149,-0.043194965,-0.0597204,0.015241228,0.0623223,0.0044777743,0.06693234,-0.10715941,-0.014509789,-0.060208708,-0.025261953,-0.028783146,-0.00020276869,0.037080903,0.018465368,0.050009858,-0.05038207,-0.041227896,0.07763734,0.06324445,-0.0011931089,0.067327745,0.03695906,0.0026028815,0.04964248,0.005757704,-0.054636765,-0.006660596,0.048634656,0.0014873464,0.021099787,0.03368881,-0.020339899,-0.015854122,-0.098140895,0.12073525,0.08419007,0.031322423,0.07658304,-0.0041693347,0.0020649412,0.03857055,-0.04353682,-0.0073954286,-0.04942371,-0.019463679,-0.03277637,0.069756955,-0.058512587,-0.014611876,-0.019221859,0.06644302,-0.0056980206,-0.035190336,-0.07595515,0.030653927,0.025829725,-0.081255764,-0.071034156,0.015187299,0.019739203,-0.005385858,0.065312915,0.09712802,0.0025786278,-0.07393076,-0.15743868,3.0892737e-33,0.08048132,0.11501238,0.017472643,-0.032198455,0.031291556,0.0069824583,-0.062928915,0.07487617,0.021408224,-0.009265695,-0.04177305,-0.058738817,-0.013901944,0.0029027418,-0.047733117,-0.09468478,-0.023757663,-0.02377349,0.0082017165,-0.06951794,0.035441518,0.08257979,0.030083345,0.056095827,0.014669685,0.010135793,-0.0022000307,0.09842774,-0.011812052,-0.009434131,-0.0015617826,-0.08949919,-0.04416997,-0.01484324,0.05346413,-0.013365039,-0.08603262,-0.029508319,0.035029672,0.12399968,0.043589983,0.046557844,0.0013611848,-0.00063188956,0.017918551,-0.060519047,-0.026385944,-0.037175294,-0.0043936605,0.017321136,0.012159034,-0.029261695,0.03926745,-0.029946106,-0.034471776,-0.01872853,0.021379407,-0.0651381,0.0010031032,0.07845322,0.012169306,0.016805388,0.028817434,-0.0046246466,-0.05104702,-0.080203615,-0.073406786,-0.04953057,0.019209592,0.046845753,0.048232708,0.015556616,0.08717492,0.035343606,0.1385488,-0.042160083,-0.05369062,-0.0074523836,0.05440806,-0.044452887,0.0569694,0.074505195,-0.040629398,0.006742218,-0.03135625,-0.0033655462,-0.07593999,-0.09837868,0.01901965,-0.035671916,0.033592906,-0.08893927,-0.033501238,-0.108659156,0.028715169,-2.965997e-33,0.06949357,-0.032744084,0.04577339,-0.078352764,-0.017958999,-0.0018861254,0.048961263,-0.008318501,0.063708484,0.000254274,0.06021252,0.0069554397,0.011374575,-0.023301933,-0.05509282,0.044445686,0.07291849,-0.00036472484,0.011925491,-0.0028170191,-0.036110897,0.01826589,0.00845292,0.019478202,0.041645296,-0.028828897,-0.06592922,0.08586227,0.13194965,0.041851085,-0.04250395,-0.023825211,-0.015543921,0.04250811,-0.010366144,0.0097360555,-0.013152052,0.07431454,-0.012787012,-0.0032861093,0.03717486,-0.06713231,-0.0004204109,0.026069766,0.02232779,0.03175895,-0.10258231,0.008947151,0.009311283,-0.04580755,0.08989949,0.007530713,-0.05132981,-0.009714288,0.036785107,0.0064659226,0.0527796,0.0012157576,-0.01966733,-0.035167437,0.015984371,-0.03920764,0.030485619,0.008501475,0.07675458,0.04116831,-0.026914066,0.07926094,0.029209726,0.111149564,0.07027324,0.01373015,0.048556983,-0.02441002,0.0062020374,-0.034854572,-0.023222325,-0.001447505,0.018144105,-0.0053079845,0.042158775,-0.06751872,0.009099259,-0.10614817,0.0011212013,-0.0042037545,0.05920108,0.064636774,-0.020940464,0.06364911,-0.042514667,0.023488088,0.0008582217,0.1051429,0.08807169,-4.4886217e-08,0.026449714,-0.10984757,-0.023163017,-0.013040334,0.020889046,0.051391233,-0.0054801377,-0.04498083,0.050057456,-0.04920412,-0.0715589,0.080395244,0.028970994,0.007810954,0.027396196,-0.0056161275,-0.05582702,0.09087653,-0.029315988,-0.014700282,-0.052721273,0.101990886,-0.08388113,-0.027497463,0.06507304,0.0014629804,0.01851757,-0.0037749412,0.01989487,-0.030690577,0.02115255,0.013804624,0.017978337,-0.056459077,-0.049762163,0.0012915387,0.0042875474,-0.043683868,-0.06762861,0.033917505,0.009416557,0.052679334,-0.1082996,0.035592478,0.013742114,-0.00909198,-0.0077056224,0.0126691805,0.022454508,0.033039656,0.058361113,0.013522262,-0.018858377,-0.07553489,-0.091347456,-0.009623359,-0.04108341,-0.0477412,0.009706058,-0.06366658,-0.00980888,0.027674869,0.21511707,-0.028819801 +2.1.1.149,The enzyme from Catharanthus roseus (Madagascar periwinkle) is unusual as it carries out two methylations of the same substrate. Also catalyses the methylation of dihydromyricetin.,384,1.0,-0.036196653,-0.013609429,-0.10357292,-0.041113466,0.0056817094,0.010533294,-0.058924485,-0.0021034218,-0.00055777834,-0.04160732,0.02873062,-0.011986061,-0.058357205,-0.026072333,-0.052204598,0.10077035,-0.1137684,0.01742369,-0.022917768,4.1529667e-05,0.081706695,0.014840952,0.033537865,-0.037162762,0.01729841,0.05614441,-0.009245241,0.024022082,0.024118282,-0.07121338,0.026818713,0.05843175,-0.05760383,0.012396696,-0.008948068,0.10940644,-0.058797993,-0.057099815,0.06479049,0.053595066,0.07642677,-0.00679681,-0.017120995,-0.06186976,-0.075849496,-0.049406517,0.020491598,0.0113702165,0.027101219,-0.051142387,-0.074809104,-0.114373386,0.035831552,-0.04855084,-0.012406307,-0.07585016,0.0166252,-0.0039872904,-0.023702195,-0.0055936985,0.049540754,0.022431547,-0.070856996,0.008650813,0.0059261895,-0.041535076,-0.02286532,-0.06274518,0.02123552,-0.090654455,0.031453647,-0.04132783,-0.05445957,-0.0018044465,-0.05446542,0.06812455,0.0327646,-0.0030660464,-0.015161775,-0.02510148,-0.04529892,0.028929943,0.06574438,0.076665156,0.07153947,0.043298427,-0.015177192,0.056261517,0.0453989,-0.009777238,0.0052387672,0.037011296,-0.007546304,-0.013153424,-0.08717736,0.07194381,-0.01325763,-0.032401346,0.018548919,0.045449417,0.014268016,0.011420725,-0.05972847,-0.017426701,-0.06311064,0.030895952,-0.02783897,0.06115822,0.012410995,-0.034138773,-0.02644589,0.02685971,0.035220426,0.044168796,-0.009530526,0.06052013,0.04799508,-0.010549354,-0.016245976,-0.029105151,-0.052415974,-0.048315495,0.06398672,-0.0026100841,-0.027770078,0.012885358,-0.15087686,2.4154181e-33,0.0751222,0.029475672,0.02082797,-0.084806316,0.058894824,0.016520588,-0.08307737,0.034296155,0.05270866,-0.074282184,-0.113354206,-0.052285813,-0.0051644575,-0.017872905,-0.075467005,-0.052285798,0.08653667,-0.03529496,0.05036794,-0.0051851817,0.06221737,0.06845095,-0.058661256,-0.0623879,-0.045766674,0.04365684,0.07954207,-0.007914882,0.07062136,-0.0021489693,0.049639683,-0.13821204,-0.045799367,-0.03385566,0.027696922,0.02119091,-0.060453884,-0.0052495752,0.04404328,0.12382694,0.0012094325,-0.037002195,0.03351148,-0.022454936,0.06834848,0.03009552,-0.023638222,0.10382303,0.012605455,0.00304789,0.018917201,0.039086085,0.1258132,-0.023838773,-0.11559267,0.015178291,0.029821547,-0.012577713,0.04941073,0.08712672,-0.011700039,-0.004904244,0.008282631,0.028663864,0.012657753,-0.039731033,-0.002346201,-0.013700134,0.028232316,0.07226089,-0.07570258,-0.02568476,0.100374036,-0.025187973,0.05832517,-0.06228148,-0.04897704,-0.013943126,0.07424348,-0.004694387,-0.058674566,0.057275802,0.0011465276,-0.03474717,-0.098543435,0.028424943,-0.013511143,-0.047753472,-0.03063894,0.06358074,0.028679606,-0.05179544,-0.037681818,-0.059202813,0.04722537,-2.581122e-33,-0.022583827,-0.07862149,0.073649175,-0.085743934,0.02491795,0.061851352,0.020639254,0.037140265,-0.049683962,-0.026184676,0.06967265,0.008503162,0.02809436,-0.019061772,0.0289479,0.07918913,-0.0021284586,0.15960632,0.0072970293,-0.032946385,-0.0489414,0.11379181,-0.037982725,0.06937933,0.04791294,0.008376143,0.021171441,0.026788522,0.04938482,0.022176668,-0.008936238,0.034679458,-0.034826264,-0.06932188,0.009366336,0.08026081,-0.07124735,-0.03357927,0.0109361615,0.06035027,-0.022642395,0.0041650967,0.0318666,0.101092555,0.027679795,0.032437753,-0.15607147,-0.0017039527,-0.0046533714,-0.012301759,0.041046917,0.04148657,0.037320863,-0.0009479162,0.07150955,0.016713144,0.018383231,0.02181157,-0.019342467,-0.014786102,-0.029981475,-0.07682052,0.015871542,0.031460445,-0.009959485,0.07024968,-0.0048807366,0.00040774955,0.028502919,0.009785001,0.043902438,-0.011364617,-0.025132982,0.047981396,-0.019973764,-0.0016739061,-0.041496992,-0.04148088,-0.025153268,-0.028873425,0.0064165895,-0.011886722,-0.005757658,-0.090436615,-0.04893657,-0.057498313,0.11127577,0.0751223,-0.047604628,0.007086402,0.021231879,0.045497704,-0.090206265,0.05914084,0.08873608,-3.145914e-08,0.041396502,-0.13281421,0.052992262,0.014736494,-0.022257034,0.007909218,-0.009684597,0.00042358527,0.0038068662,-0.02214569,-0.013440254,0.053650945,-0.0055378266,0.011967534,-0.015228023,0.003521552,0.079223566,-0.0071007665,-0.0041665714,-0.0097919,-0.061270565,0.099571235,-0.04640292,-0.038859792,-0.0008548625,-0.024003115,-0.030329771,0.06529106,0.018616412,-0.018602598,0.0674376,0.03848505,0.009646129,-0.06603739,-0.09198244,0.027039867,-0.008816473,-0.060416337,0.006126756,-0.07718272,0.03197352,-0.0597611,0.034656774,0.032615975,-0.02766562,-0.027501516,0.007315928,0.056576714,0.029613359,0.0020112528,0.017101472,0.03204403,0.030037228,-0.09102356,-0.1017833,-0.0047426596,-0.055852976,-0.05188155,-0.05383621,-0.03040373,0.063593365,-0.03496253,0.16586053,-0.02957062 +2.1.1.150,"The enzyme from alfalfa can methylate daidzein, genistein and 6,7,4'-trihydroxyisoflavone but not flavones or flavanones.",384,1.0,-0.047925323,-0.034621794,-0.15898357,-0.012504648,0.05272603,0.10910402,-0.13019463,0.012867925,-0.01442785,-0.090498745,0.004171595,0.028779844,-0.08481897,-0.041354828,-0.03653446,0.05292408,-0.046589572,0.043122035,-0.089313544,-0.039535772,-0.01544755,-0.022096166,0.077052504,8.0981736e-05,0.053362742,-0.04187424,0.00946754,0.008800117,0.02185741,-0.068212226,0.02676322,0.103289075,-0.01744476,0.008329195,-0.034222484,0.08368858,0.047047317,-0.06522726,0.030369047,0.021627182,0.06697243,0.00013262725,-0.029015455,-0.06851169,0.055876598,-0.05125255,-0.049481247,0.012651675,0.03523257,0.044130296,-0.09872083,-0.06616464,0.008729375,0.047431022,0.020249564,-0.024020243,0.09525003,0.0098507535,-0.051558472,0.0712952,0.022057835,-0.04921629,0.0062460615,-0.036036577,-0.056831535,0.011621064,-0.0966817,-0.029216433,-0.006498289,-0.069845594,-0.0020461066,-0.0735891,-0.033525437,0.06737476,0.013246329,0.05706474,-0.013642216,0.027162736,0.046590816,0.026641788,-0.04394378,-0.006380659,0.046944637,0.02644012,-0.016751036,-0.009848434,-0.05572009,0.016446546,0.0473603,0.08420283,-0.02086268,0.062643,0.044562154,0.007822475,0.019489082,0.074195586,0.05984821,-0.06851834,-0.03045809,-0.008710379,-0.0029356459,-0.049509395,-0.083225034,-0.03356302,-0.03254751,0.02971583,-0.0049702167,0.009594917,0.016875735,-0.030433912,0.013406254,-0.022556541,0.025476871,-0.046128113,-0.06861681,-0.0066077523,0.004233201,-0.04136864,-0.049621847,-0.021904798,-0.008147029,0.050439414,0.1290594,0.042101808,0.036996868,-0.035104908,-0.036760505,3.8366325e-33,0.09198833,-0.0010164807,-0.059269585,-0.045560073,0.04613408,-0.008916391,0.009219754,0.03553615,0.045000996,-0.07753761,-0.09644499,-0.015577379,-0.04703162,-0.051140845,0.06548492,0.046039376,0.0071420115,-0.08741216,-0.0023049966,0.0011400034,0.080710426,-0.048802055,-0.08344737,0.06282228,0.0074630813,0.040793173,0.010214405,-0.013094596,-0.0019884338,-0.011888532,0.006888676,-0.1286347,-0.016155777,0.013624086,-0.03751983,0.041313622,-0.11199069,-0.02590782,-0.08221847,0.10069003,0.064003944,0.0024225134,0.03215458,0.037874214,0.024248648,0.049208954,-0.01402893,0.045702722,0.0399901,0.047046367,-0.003029283,0.03499957,0.06001416,0.037359137,0.02034009,0.044916634,-0.011215516,0.05157848,-0.0023666432,0.035248578,-0.0329169,0.004041742,0.06739092,0.05921363,-0.068801135,-0.035693027,-0.041896086,0.0010836016,0.010954397,0.036794,0.044080496,-0.06732363,0.03662275,0.026598396,0.03125381,-0.0936411,0.038552936,-0.040726725,0.035723496,-0.045007203,0.040632315,0.020725323,0.0050448184,0.033839267,-0.14218475,0.033338767,-0.042931695,-0.008370988,-0.02208414,0.005277014,-0.005099587,-0.005479565,0.013976458,-0.0519839,0.0037325234,-3.8071797e-33,0.029195381,-0.015904486,0.008405168,-0.015481425,0.0022446348,0.027497215,0.011885004,-0.0476606,-0.0059633693,-0.008332393,0.043834124,-0.048618406,-0.023323229,-0.009958042,-0.027440581,0.05989749,0.035646606,0.063003644,0.0387808,0.013243492,-0.082692556,0.042666048,0.03346615,0.05040092,0.076043844,-0.014816051,0.059380684,-0.015030459,0.020661276,0.058587376,-0.009283493,0.011785313,-0.0046715485,0.0073041045,0.020182718,0.07632532,0.00053742673,-0.051219206,-0.05540456,0.037941866,0.028848784,-0.019833669,-0.038558275,0.048633736,-0.024370912,0.010482133,-0.10920056,0.017667085,0.010033453,0.021636924,0.050085343,0.0765646,-0.0026715964,0.08215736,0.028240817,-0.018959163,0.051651116,0.0108452495,0.003535598,-0.025117455,0.031430256,-0.05735886,-0.013659069,0.014173499,0.085424274,0.06769428,-0.029591536,0.046093166,-0.016266627,0.025834266,0.10773161,-0.046874184,0.08253906,0.1080016,-0.059626386,-0.0093160225,0.008614228,0.02130355,-0.04278461,-0.06603014,0.0033926652,0.0062311934,0.008494505,-0.06005447,-0.043251466,-0.032410715,0.0070735095,0.062333606,6.860333e-05,0.11702735,0.0066162003,0.00040602928,-0.05643639,-0.019403547,0.032342516,-3.0844816e-08,0.056893673,-0.072838776,0.0076597375,-0.00041838945,0.018187575,-0.03855652,-0.052590884,-0.05093432,-0.019644095,-3.8597565e-05,-0.07402733,0.102868386,-0.0498833,0.05087757,0.017392455,-0.0628439,0.00095130043,0.037428003,-0.022231579,0.052401967,-0.09231388,0.078361735,-0.14835583,-0.024155334,-0.022129918,-0.003979896,-0.05527512,0.05205561,0.16008659,0.042849697,0.048657104,0.04691935,0.06713792,-0.09040355,-0.13691351,-0.016694792,0.02508809,-0.021009477,-0.06202282,-0.02749926,-0.07049906,-0.07001475,0.03905604,-0.015748734,-0.0808248,-0.07405381,0.03583973,0.0040918454,0.07401927,0.040394057,0.017097088,0.0051704985,0.026389921,-0.051842112,-0.07141707,0.0014674972,0.047405403,-0.07033425,-0.0036215407,-0.07752779,-0.04984199,-0.049298592,0.18442436,-0.01100854 +2.1.1.151,"This enzyme participates in the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway. See EC 2.1.1.130, precorrin-2 C20-methyltransferase, for the equivalent enzyme that participates in the aerobic cobalamin biosynthesis pathway.",384,0.9999999,-0.054886192,0.04030923,-0.16049404,0.020947289,0.08936624,0.060785327,-0.09438144,0.018682903,0.0548993,-0.04361319,-0.009872469,-0.09470863,-0.04730781,-0.021020675,-0.028959611,0.040922176,-0.057416286,-0.04573922,-0.050360132,-0.04979041,0.01649304,0.02024931,0.009237544,0.045400295,-0.0032011815,-0.04871063,0.02830991,0.035457328,0.031052757,0.039636075,-0.00878961,-0.009013853,0.06158051,0.007129667,-0.019928865,0.0999119,0.04198119,-0.016502965,0.050759017,0.007146591,0.01389237,0.03190841,-0.02471729,0.0058605685,0.013770442,-0.015768064,0.035939276,0.026279844,-0.03265661,-0.0051646517,-0.039383493,-0.014377472,-0.02563393,-0.008955475,0.020099208,0.049243983,-0.049519222,-0.08184557,0.04945123,0.008370832,0.03778756,-0.087863445,-0.02421037,0.017662754,0.014713107,-0.014274529,0.077974804,-0.051558767,0.051828943,-0.06642563,-0.033140738,-0.082414284,-0.038241033,0.004890974,-0.042475857,0.06850979,0.015918331,-0.03178331,0.02368893,-0.05143212,-0.0069984426,0.046535883,0.015034153,0.022960456,0.03383737,-0.012556622,-0.014425251,0.0147674745,0.018467508,0.074903265,-0.033932693,-0.013805657,0.04250426,0.00965611,-0.13662614,0.010342233,0.056161985,0.093289286,0.03258636,-0.0364986,0.056840174,0.09325055,-0.03649354,-0.00976124,0.049922653,-0.062034234,0.10487706,0.16839358,0.019051298,0.032029673,0.020283831,0.036599826,0.0070471927,0.024623493,0.0074798716,0.14550412,0.04417257,-0.027516067,-0.074082784,0.06670815,0.043590203,-0.020692796,-0.016877213,-0.006886429,-0.030883815,-0.0732187,-0.02788884,9.503969e-34,0.061144695,-0.0005662241,-0.00012915055,0.01622774,-0.029007435,0.017979927,-0.1385104,0.03222936,0.018282572,-0.06923997,-0.024260813,-0.064543225,0.016357925,0.08377447,-0.09376668,-0.08343339,-0.028344337,-0.08304313,0.062766925,0.03905188,-0.016072841,0.048401374,-0.03569938,0.012475215,0.04969535,0.06429814,0.0017407446,0.044433057,0.021600014,0.0069711017,0.018139238,-0.08389613,-0.08689343,-0.06003016,0.04639162,0.008659241,-0.033183463,0.03496451,-0.003942636,0.06751724,0.021168986,0.026916616,-0.09634618,-0.01118486,0.036577646,-0.08471851,-0.02851809,0.11057904,0.050990287,0.026198106,0.0032222997,0.0038576864,0.099223,0.021164052,-0.030049548,0.010112222,0.009277264,-0.03638153,-0.036708146,0.053927824,0.048655897,-0.0078244135,-0.036317073,0.12621139,0.00019258182,-0.05457558,-0.0433082,-0.044466786,0.021810899,-0.009938756,-0.06044435,-0.06876049,0.060135424,0.06149082,0.02476524,-0.029913884,-0.07877234,-0.067379825,0.0053012758,-0.045391817,-0.052902408,-0.004196235,0.017607484,-0.054231293,-0.08219039,0.020746563,-0.0088651385,-0.072461635,-0.017772302,-0.07319379,-0.010482416,-0.017793475,-0.037713736,0.0325267,0.04087946,-3.098149e-33,0.0912519,-0.06179313,0.058687672,-0.1378242,-0.03509584,0.09697555,0.05699293,-0.10296488,-0.016817708,0.005488016,0.1000526,-0.03883231,0.027695455,0.008511038,0.016820908,0.011332539,-0.034026355,0.08186608,0.01684342,0.0088502215,-0.008074238,0.0068416237,0.00040645272,0.004470081,0.008226348,0.07908973,-0.0015432647,0.03470403,0.03710561,0.09419553,-0.062430866,0.02283458,-0.012418099,-0.04308012,-0.0144356685,0.0807323,-0.018685143,-0.022953736,-0.03908596,-0.026774308,0.014132669,-0.0045837355,-0.03310464,0.046339206,0.036756124,0.06360783,-0.0339051,0.042766012,-0.08754398,-0.023933997,0.038052563,0.053576935,-0.07050943,0.07907115,0.08510396,0.008629035,0.0107579455,-0.031356078,0.04849246,-0.10337919,-0.07244712,0.020320686,0.008040221,-0.033354934,0.041057806,0.000557039,0.02389063,0.08910933,0.030911507,0.025838131,0.069433086,0.048115842,-0.004924676,0.0060683377,-0.107860416,-0.015884062,-0.044234056,-0.048884567,-0.0491687,-0.06871503,-0.071659304,-0.0060993973,0.061249003,-0.03451478,-0.107881226,-0.073691115,0.042434413,0.042887744,-0.03915259,0.051333886,-0.039716024,-0.0015121383,-0.07850145,-0.006796575,0.03919622,-3.1384054e-08,-0.012896639,-0.07947437,0.053802617,-0.0045036087,-0.01246249,0.06348281,-0.033575546,-0.014296681,0.040597595,0.038511574,0.0054728035,0.06437228,0.050348718,-0.04593068,-0.07435782,0.0028427567,-0.011906057,0.033797454,0.022255734,0.016436998,-0.057483315,0.013769426,-0.028250033,-0.034242522,0.04745262,-0.112810574,-0.065093,0.087412685,0.020843139,-0.041928288,0.02380075,0.023687433,0.074456096,-0.065375775,-0.04628922,0.06624469,-0.0034158917,-0.043094154,-0.032149564,-0.020341402,-0.05147351,-0.051732946,-0.08117476,-0.0008063242,0.034962438,-0.023535777,0.011728936,0.07046602,-0.029790925,-0.039045036,0.011425261,-0.056264848,0.010743708,-0.0112053985,-0.042841233,0.04011981,-0.067927375,-0.048414163,0.0046604406,0.013421863,-0.0010992833,0.0656606,0.076640934,-0.12739779 +2.1.1.152,"The enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosythesis pathway, catalyses two reactions -the methylation of carbon C1 of precorrin-5, and its deacetylation, forming precorrin-6A. See EC 2.1.1.195, cobalt-precorrin-5B (C1)-methyltransferase, for the C1-methyltransferase that participates in the anaerobic cobalamin biosynthesis pathway.",384,0.9999999,-0.04593559,0.04600718,-0.12917459,0.032482892,0.07906768,0.07756008,-0.09687499,-0.010040884,0.038900033,-0.021210773,-0.021406736,-0.06431254,-0.053064786,-0.028509792,-0.030350389,0.030992432,-0.076552354,-0.027787091,-0.07535697,-0.037535433,0.0040189023,0.02002793,-0.020726256,0.06544546,0.04002829,-0.05718122,0.010475762,0.023090908,0.016039241,0.0153860375,-0.040728163,0.023799144,0.038198348,0.0017136519,-0.040364664,0.10832631,0.03500849,-0.02087344,0.077426195,0.012304374,-0.0040768674,0.034735736,-0.008973597,-0.0040103467,0.02062859,-0.0084281415,0.01993223,0.022382222,-0.009052309,-0.03277058,-0.051890403,-0.019938951,-0.07180843,-0.028227309,0.016024215,0.024159819,-0.035504144,-0.08540833,0.06863057,-0.0071001695,0.014775106,-0.07706234,-0.04225579,0.025422782,0.017498365,-0.023153538,0.057421457,-0.054129113,0.06104461,-0.0423042,-0.0291633,-0.08668583,-0.025542634,-0.014221267,-0.03991728,0.058776308,0.00027800188,-0.025223454,0.013956819,-0.028629204,-0.013500292,0.05236141,0.0049931128,0.020836812,0.03939076,-0.0061623435,-0.037644047,0.033908427,0.044439495,0.07626356,-0.030847901,0.010323388,0.053073402,0.00333676,-0.17298959,0.0021283082,0.04641635,0.070881836,0.055276856,-0.026493322,0.037156284,0.08611588,-0.056759894,-0.013072899,0.057779405,-0.04515574,0.0809299,0.1888663,0.032770365,0.043810077,-0.0041091703,0.048115022,-0.01501385,0.041636586,0.013838041,0.14918113,0.04585266,-0.04434619,-0.08010342,0.05014615,0.043967675,-0.02076665,0.017993942,-0.016762916,-0.06900261,-0.080800086,-0.016379831,1.7861484e-33,0.06818539,0.0039144256,-0.0020927174,0.020732753,-0.016843006,0.017809087,-0.131924,0.036310267,0.033090323,-0.033984896,-0.0035020104,-0.049811427,0.01632286,0.04347127,-0.07152887,-0.07214521,-0.0037980631,-0.06475314,0.03387017,0.036393754,-0.024275817,0.07619368,-0.033797763,0.025521392,0.03171855,0.06255995,0.009854723,0.046493124,0.016562948,-0.0035604425,0.0073869512,-0.07315267,-0.06870634,-0.05633418,0.06384609,0.0056615123,-0.038466502,0.059358314,0.013259087,0.072096236,0.033968702,0.028259352,-0.12228586,-0.014819587,0.059774812,-0.05241486,-0.025655372,0.09744458,0.037849646,0.0135318,-0.010680449,0.024461156,0.10909283,0.04106195,-0.039623827,0.023632366,0.025172038,-0.02912446,-0.031967584,0.06497938,0.06977828,-0.0029307788,-0.019072821,0.1008324,-0.014805242,-0.033961147,-0.044355437,-0.04415476,0.025246777,-0.018856624,-0.053075146,-0.05961078,0.05491026,0.058910593,0.029924667,-0.027444191,-0.07059714,-0.072320305,-0.013551291,-0.036775585,-0.03973193,0.02755435,-0.0018876357,-0.037096217,-0.08302839,0.061869178,-0.01334697,-0.07027272,-0.012269875,-0.052043784,-0.010128943,-0.016203651,-0.033030033,-0.0026294773,0.039371297,-2.9968843e-33,0.10794153,-0.07148814,0.048207704,-0.12759085,-0.038504057,0.059439678,0.05558891,-0.13232082,-0.03388414,-0.008492445,0.07293284,-0.03835005,0.012585183,0.015805315,0.0037665865,0.014034016,-0.013677622,0.0813559,0.009874061,0.011893168,-0.012303619,0.0019016498,-0.03485287,-0.011285588,0.020073067,0.09210874,-0.0098483395,0.019005088,0.0734076,0.07429727,-0.04533286,0.0008835199,0.013745125,-0.039551098,-0.021665128,0.087698445,-0.032230742,0.00032119494,-0.020565076,-0.022135904,0.012484729,-0.012305107,-0.03198886,0.04662463,0.05052087,0.05576674,-0.0660626,0.048830166,-0.052427903,0.0035825488,0.0732498,0.032805488,-0.08376626,0.046146147,0.063735664,0.0036165703,0.04727232,-0.053293318,0.042255186,-0.098467864,-0.054523468,0.00411431,-0.0014691469,-0.03921709,0.04530432,0.013282048,0.041474264,0.10057094,0.032131247,0.020905236,0.05249227,0.08084037,0.012581679,-0.0047053727,-0.078602396,-0.0074889995,-0.035113726,-0.055787385,-0.04232658,-0.053727858,-0.06749113,0.0015924126,0.053863186,-0.045803256,-0.11830629,-0.07984727,0.051114995,0.028898645,-0.04140229,0.085680634,-0.041165926,-0.032270864,-0.032675046,-0.010272737,0.034009002,-3.719871e-08,0.01794358,-0.092219494,0.06548313,-0.00023693842,-0.021809673,0.07526148,-0.04274951,-0.016838295,0.07066962,0.021103911,-0.0029779,0.06305593,0.055645246,-0.018926606,-0.11111797,-0.0046487316,-0.035633728,0.014389439,0.012300603,0.009245255,-0.0713574,0.019723762,-0.046084855,-0.036519878,0.0655992,-0.12327349,-0.073997974,0.09386442,0.007164947,-0.023798164,0.012827273,0.041029327,0.07378088,-0.06597478,-0.00105588,0.031350605,-0.01588654,-0.056339134,-0.053859547,-0.020157594,-0.041041926,-0.0403895,-0.110979035,0.010208785,0.02357794,-0.03772844,0.009024476,0.045511566,-0.02067822,-0.008984812,0.04091794,-0.03773456,0.022899369,-0.008503195,-0.040382612,0.039887153,-0.041063476,-0.052594274,-0.018183425,0.014387573,0.0026664054,0.039266523,0.09739681,-0.12584354 +2.1.1.153,The flavonoids vitexin and isovitexin 2''-O-arabinoside do not act as substrates for the enzyme from oats (Avena sativa).,384,1.0,0.017205894,-0.09115698,-0.027496675,0.052793812,0.07016846,0.027006872,-0.06799166,-0.018820452,0.06787091,-0.06447665,0.06465604,0.013006147,-0.056154773,-0.059799492,-0.023885375,0.014034744,0.051442515,0.035363164,0.01297694,-0.049751934,0.051054023,0.008221905,0.034080714,-0.03238515,0.021727752,-0.07021824,-0.03461003,0.010991753,0.04258888,-0.07284917,0.030205917,-0.041795336,0.037278898,0.0063341204,-0.042644914,0.022449857,0.028253822,-0.12666398,-0.026968852,-0.04056754,0.08421833,-0.004878579,-0.011974983,0.0014919486,0.038911782,-0.06345578,0.020373637,-0.05418188,0.027350845,0.012263812,-0.06040636,-0.06276209,-0.0686299,-0.0019193765,-0.04586948,0.016478265,-0.01939632,0.0012884025,-0.03568747,0.080140315,-0.010359059,0.038870227,0.04029868,-0.009211234,-0.029063122,-0.026176497,-0.0067911907,0.0136469705,-0.001809381,-0.042924847,0.0025012759,-0.029107882,-0.036228932,0.0019125612,0.013994894,0.03844099,-0.07973025,-0.041897878,0.010914534,0.035970904,-0.019522933,-0.03135059,0.021830069,0.10068535,-0.03246593,-0.068362705,-0.037551392,0.0066685025,0.055589505,0.0076855803,0.06975399,0.0027254377,0.030294731,0.029698761,0.08497489,-0.019186182,0.041534394,-0.004821893,-0.0680586,-0.0024725285,-0.08384561,-0.0015456157,-0.12712315,-0.0015167012,-0.00040324428,0.071261644,-0.008113791,-0.060680714,-0.007646712,-0.032975186,-0.0013906198,0.010207374,0.024167372,-0.037137534,-0.052054618,0.012619524,-0.041608974,-0.08611593,-0.038934797,-0.060032748,-0.06959583,0.036608864,0.10209504,0.06878281,-0.024280917,-0.010367922,-0.056960024,1.611674e-33,-0.034097057,-0.020135667,0.05730773,-0.027293883,0.0413574,-0.054403286,-0.009666398,0.018467082,0.0008334811,-0.036213268,-0.16753602,-0.064559035,0.021396507,0.03711136,0.08451197,-0.02277477,0.048699237,-0.06398522,0.06184949,-0.0036624135,0.041399047,-0.02674578,-0.015205323,0.057148542,-0.033239253,-0.016978832,0.029625295,-0.049846232,-0.045634743,-0.0013312537,-0.017803589,-0.058140263,-0.05987579,0.031105943,0.03665989,0.010455544,-0.05455391,-0.04636894,-0.0670999,0.017206106,0.0015019745,0.037277564,0.016901156,-0.058220237,0.042158175,0.026141977,-0.03757358,0.16031136,0.07932466,0.06108486,0.053847916,0.00075081695,0.011441359,0.04649516,-0.05745719,0.044908457,-0.022779495,0.041995153,0.016571814,0.06195968,-0.06495098,-0.008719661,0.028103225,0.033539064,-0.048548307,0.118943475,-0.059362903,-0.056963887,-0.018423988,0.081557974,-0.01118769,-0.0012841736,-0.028212845,0.006454447,0.03518129,-0.051437296,-0.06396479,-0.009119318,0.06677206,-0.00471545,0.05126413,-0.056601737,0.041147683,0.020090908,-0.0891738,-0.029194327,-0.014825248,0.07018423,0.076141976,0.07546108,0.116202764,-0.0022963176,0.02049704,0.037157673,-0.020462073,-2.1043028e-33,0.034875587,-0.08535671,0.06376174,-0.041833982,-0.037112616,0.04780579,0.001534677,-0.014186896,0.08467842,0.015120222,0.020800943,-0.00021508556,0.018646266,-0.09475497,-0.045486182,0.0434149,-0.012282612,0.11807158,0.023271127,-0.013315368,-0.13327928,0.026570136,0.03543927,-0.028022699,0.0519756,0.011968652,0.104760565,0.048078343,-0.05829425,0.05580961,0.06157794,0.034616802,-0.053285744,-0.017148415,0.008036441,0.09076265,0.008614191,-0.04083424,-0.042090595,0.03624687,-0.039295573,0.08248072,0.017312372,0.008162011,-0.019487062,0.063793786,-0.11759839,0.038611576,-0.054751895,-0.13587096,0.07001916,0.0064362134,0.06339685,0.011691983,0.048171032,0.035149895,0.013654198,0.016312908,0.0069614663,-0.051854786,0.044143114,-0.01709502,0.014363238,-0.05031922,0.02749503,-0.01940139,0.012412902,0.059732456,-0.008071457,0.020057557,0.078073524,-0.0021008372,0.02061179,0.027743964,0.042674642,0.049975123,-0.017533518,0.00033832272,-0.025375929,-0.01725128,0.0059033013,-0.005720995,0.0038812854,-0.03856739,-0.03968714,-0.008218814,0.023845391,0.12968953,0.063703276,0.1072679,-0.07930423,-0.039577786,-0.059188545,0.001973142,0.09893155,-2.960229e-08,0.022504799,-0.057038017,0.027051177,0.019319914,-0.052859105,0.011044552,0.016483467,0.045735046,0.0003380669,0.033228744,-0.08435454,0.07074174,-0.018672457,-0.04404097,-0.022632448,-0.024883378,0.04462465,0.093107186,-0.009193042,0.0710555,-0.059738535,0.01051831,-0.09141208,-0.031561036,-0.008535514,-0.054263953,0.012142662,0.028922202,0.0621208,0.017011138,0.07229724,0.007813045,0.020098537,-0.08828075,-0.15186758,0.014480825,0.035871454,-0.057509594,0.019287938,-0.0060356935,-0.08024906,-0.07138475,0.05148935,-0.04822545,0.012400413,0.0024729175,0.0025301327,0.018534245,-0.0023764218,0.00022760122,0.092895575,-0.00045228342,-0.028444003,-0.009706038,-0.04978115,-0.105015755,0.0046234503,-0.046467766,-0.010931801,-0.12006148,-0.008460012,-0.022516714,0.19765319,-0.034301613 +2.1.1.154,"Not identical to EC 2.1.1.65, licodione 2'-O-methyltransferase [2]. While EC 2.1.1.154, isoliquiritigenin 2'-O-methyltransferase can use licodione as a substrate, EC 2.1.1.65 cannot use isoliquiritigenin as a substrate.",384,1.0,-0.008107304,-0.06827383,-0.038637657,-0.018350106,-0.009443174,-0.03141071,-0.06511866,0.017598629,0.016010724,-0.11351837,0.13671046,-0.06956563,-0.062724926,0.022442829,0.026077786,-0.016876861,0.043918286,-0.00896821,0.005937856,0.0715127,0.05700501,0.0007554978,-0.04642543,-0.012406091,0.005359384,-0.08201754,-0.05913172,0.031397365,0.145301,-0.12040069,0.062735096,-0.013001595,-0.04645072,-0.09293318,0.047708455,-0.006632295,0.028095936,-0.039644226,-0.06229296,-0.021049505,0.11861818,-0.03292669,-0.045905992,-0.020644818,-0.07653424,-0.11276937,0.034731366,-0.08380952,-0.06449465,-0.040165927,-0.021330502,-0.033700664,-0.040961195,0.03732989,-0.031069426,-0.044483278,-0.04066713,0.041709065,-0.0010001509,0.015760155,-0.06430579,0.0303357,0.017535735,0.036373407,-0.037173722,-0.04574246,0.102873564,-0.13376033,-0.02810259,-0.046049517,-0.0892405,-0.11312495,0.026037598,0.08435914,0.03790408,0.050673377,-0.034961604,-0.033258263,-0.018339394,-0.049183864,0.00891698,-0.0023389724,-0.04211632,-0.003503223,-0.079411164,-0.038566224,-0.042543825,-0.017035343,-0.0014905492,0.007300968,0.08705029,0.049194917,0.104670234,-0.032069135,0.04246823,0.054010496,0.0750187,0.11648597,0.022163805,0.009144703,-0.04598252,0.1396917,-0.20452493,0.0039030584,-0.010817987,-0.016102837,-0.013957806,-0.014502841,0.0065805065,-0.030843511,0.041770704,-0.011534228,0.048746984,-0.038890228,-0.029669534,4.09419e-05,0.022631833,-0.032965638,0.06331523,0.0012964647,-0.0003690564,-0.08968042,0.0649377,0.076392055,0.03120424,-0.06997579,0.0022079118,1.9204038e-33,0.04060172,0.0027503325,0.028770866,0.025977971,-0.03564805,-0.0017803189,-0.1120771,0.0018777702,0.005214292,-0.15073326,-0.04002083,-0.06259961,-0.057554446,0.12316408,0.059423126,0.020369215,0.020415606,0.033510737,0.06529736,-0.03945737,0.006215833,-0.010565261,-0.0004507139,-0.008322174,0.033408757,0.072137386,0.051716533,0.016162314,-0.018810071,-0.014759428,0.025949739,-0.060730204,-0.021250326,0.08309089,0.009506698,0.010404517,-0.012808042,-0.008614259,-0.017639283,-0.036460295,0.005691071,0.06925347,0.027032798,-0.07476778,0.06853053,-0.023102297,-0.01763939,0.011845951,0.052312568,-0.021377869,0.027336659,-0.008685667,0.012432606,-0.008121943,0.053695906,0.0026453955,-0.027221052,-0.01310781,0.05550979,0.06828333,-0.008228135,0.08791641,0.0068744333,0.024894606,0.01299619,0.022529576,-0.10362501,-0.03269478,-0.07369739,-0.0026308384,0.0017581034,0.017978638,0.080651246,0.0119542265,0.089786656,-0.061967257,-0.07583389,0.0025629243,0.070500255,0.022315323,-0.018401435,0.031336244,-0.022165053,0.0009141664,-0.09373177,0.012359851,-0.01918631,0.053683516,0.03640304,0.07062611,0.0010012116,-0.02402094,-0.03405986,0.029683245,0.005817297,-4.3755827e-33,-0.0052610557,-0.036031246,0.027946983,-0.07907815,-0.002974599,0.00682495,0.005618282,0.018700812,0.022344563,0.026591567,0.083900936,0.034063637,-0.029579204,-0.04517747,0.02050919,-0.03507653,-0.041439716,0.009408318,-0.0048895786,0.02397302,-0.059693806,-0.037370607,-0.024886057,0.08036059,0.09563506,-0.012423575,0.036997218,0.065745495,0.01386874,-0.011533536,-0.061271194,0.06106162,0.004863767,-0.0017508015,-0.023869868,0.024432465,-0.056877185,-0.029926123,-0.07340192,-0.032099042,-0.046383284,0.024232237,-0.01109463,-0.050714098,0.01370524,0.0313961,0.013622935,-0.052691486,0.08740342,-0.019988896,0.00036701013,0.042574875,-0.05377494,0.03575675,0.039714597,0.026507309,-0.008381329,0.07328483,0.0056913425,-0.092790134,0.024382299,0.022708863,0.029367115,-0.030085724,0.06517054,0.06367093,-0.023636658,0.041661285,-0.096230745,0.06830525,0.06331078,-0.07295609,0.029602157,-0.06850741,0.00797779,-0.046319656,0.006688382,-0.0042802054,-0.064696126,-0.05368237,-0.020606725,-0.019639935,-0.01540206,-0.0049433624,0.016493175,-0.005099545,0.030820653,-0.006511862,-0.04944188,-0.0014501866,0.012395398,0.017858457,-0.060681377,0.045352623,0.040417377,-4.0854427e-08,0.0035196443,-0.06802453,0.00043996907,-0.054959383,-0.029229455,0.0064105014,-0.032662686,0.017412992,-0.008219569,0.040648744,-0.006702173,0.016717417,0.013112916,0.003539533,0.030838495,0.028943673,-0.05825295,0.036637697,0.007887343,-0.030495383,-0.04250768,-0.009593941,-0.0324826,-0.03474001,-0.06616648,-0.044734396,0.019873913,0.05350288,0.061816406,-0.09559128,0.06417101,0.03361976,0.043598145,-0.013473179,0.0017482573,-0.035724107,0.0005697914,-0.047553137,0.014824045,0.08246703,0.030256953,-0.002554571,-0.009354669,0.029788356,0.11844232,0.0729059,0.05016719,0.061441507,-0.024222527,0.050513044,0.06293087,-0.08471157,-0.01753702,-0.11918137,-0.022831134,-0.037142534,-0.033013072,-0.01354583,0.049190182,0.020583995,0.09797399,-0.01166696,0.19606555,5.5162567e-05 +2.1.1.155,"The enzyme acts on the hydroxy group in the 4'-position of some flavones, flavanones and isoflavones. Kaempferol, apigenin and kaempferol triglucoside are substrates, as is genistein, which reacts more slowly. Compounds with an hydroxy group in the 3' and 4' positions, such as quercetin and eriodictyol, do not act as substrates. Similar to EC 2.1.1.75, apigenin 4'-O-methyltransferase and EC 2.1.1.83, 3,7-dimethylquercetin 4'-O-methyltransferase.",384,1.0,-0.018857336,-0.056739602,-0.10092247,0.009390256,0.06597913,0.08850724,-0.082781985,0.0018182073,0.059274722,-0.10294176,0.057434868,-0.09370661,-0.10433547,-0.024716849,-0.05198349,0.00407833,-0.031489406,0.02693754,-0.04019827,-0.054750826,0.07255867,-0.08535648,0.05490321,-0.010811558,0.0079112435,-0.0012174448,0.0032774343,0.010076254,0.05212798,-0.13156502,0.02223718,0.067458756,-0.04197401,-0.0027371536,-0.05636197,0.10049647,-0.02502372,-0.059410818,0.0677472,-0.017075082,0.06719724,-0.051457297,-0.030931804,-0.0062030284,0.05238897,-0.05902161,-0.023029098,-0.0022884011,0.015625307,0.004378614,-0.022011662,-0.05926965,-0.029757636,0.04757711,0.016413374,-0.054226507,-0.02434647,0.035212122,0.0009644957,0.07912951,0.092879996,-0.011831702,0.019405024,-0.009280847,-0.08336186,-0.0128124785,0.028501457,-0.040377058,-0.0043162126,-0.049689103,-0.09239127,-0.053684905,-0.05352176,0.06324726,0.039237976,0.06562695,-0.028603187,0.022918876,-0.034300894,-0.03941645,0.03240987,-0.0007201978,0.021011954,0.080276564,-0.031152632,-0.057373006,-0.051295497,-0.032076348,0.03187223,0.099447355,0.057127852,0.07381236,0.023889069,0.016962515,0.059536885,0.06875132,0.042297326,0.029338082,0.045501363,-0.019333936,0.022357425,0.03768685,-0.08016768,-0.0065980577,-0.012600969,-0.0041619795,-0.0021964293,0.014062014,0.05829118,-0.030935766,-0.021795582,-0.037850186,0.023463253,-0.048254393,-0.06383514,0.014057452,-0.013483022,-0.06618712,0.011005657,-0.020001352,-0.012016615,0.033203278,0.08717492,0.06823054,0.013447281,-0.0011285221,-0.035928514,3.2998202e-33,0.11312036,-0.012985611,-0.032064285,-0.0037581248,0.028460372,-0.0063037965,-0.0056797704,0.051256362,-0.058393754,-0.055106044,-0.15652502,-0.02848865,-0.030132491,0.05128599,-0.0026212903,-0.032438613,-0.027023524,-0.048626363,-0.002624204,0.0028862222,0.0057167024,-0.012882465,-0.10527484,0.025859032,-0.02224206,0.08110691,-0.06396341,0.02869055,-0.017057223,-0.016971173,-0.06660348,-0.105548546,-0.042212717,0.032481704,-0.014046901,0.04687291,-0.03353171,-0.016378965,-0.0020992607,0.0662021,-0.026941106,0.043713644,0.05202633,-0.044899862,0.031209527,0.027251981,-0.038769223,0.03914092,0.04820004,0.049625944,0.025863761,-0.033482693,0.09866237,0.038825326,0.0051058223,0.055035558,-0.060006455,0.0071680797,-0.005463631,0.043977533,0.023436071,0.055253305,0.0023060373,0.069340706,-0.044604734,0.053384032,-0.049537294,-0.040625,0.011675363,0.059637196,0.04234346,-0.012457683,0.08448584,0.0123905875,0.09844912,-0.045186147,-0.069171965,-0.044579282,-0.040671155,0.059684847,0.00029802916,0.05125242,0.004821858,-0.021548115,-0.12613057,0.0103866765,0.01782846,-0.015583143,0.025820518,0.059288893,-0.026205977,-0.09046993,-0.022167113,-0.01687489,0.026657227,-4.5339232e-33,0.1033177,-0.04019953,0.030738914,-0.052731693,-0.060216412,0.06036207,0.04522022,0.001962281,-0.028504364,0.078267574,0.080096506,-0.031653408,-0.011411252,-0.009784068,-0.021663789,0.0031652986,-0.033361938,0.062212747,0.010111604,0.020764226,-0.04187082,0.06076259,-0.026428374,0.1073582,0.07991921,-0.020009926,0.06230074,0.01217646,-0.04024143,0.064453624,-0.06878095,-0.0425079,-0.018869257,-0.014440563,-0.010664998,0.06445659,-0.027039917,0.031806834,-0.08464061,-0.019588806,0.010298703,0.028830457,-0.03565579,0.07499711,0.04528104,0.10606969,-0.08026863,0.040331315,-0.026459992,-0.008048865,0.012014493,0.08989253,0.006776863,0.062386926,0.018924557,0.045520324,0.022478053,0.007603055,0.0016543982,0.002447537,-0.019705994,-0.1397812,0.028261717,-0.031337563,0.045018293,0.106465034,-0.03508259,0.09165584,0.033387884,0.026168628,0.08926277,-0.092658944,0.016853202,0.055709276,-0.024110459,-0.022694819,-0.031863067,0.020256432,-0.05594643,-0.027453782,0.020099513,-0.060138047,0.0021692214,-0.10064209,-0.08126415,-0.06846081,0.065377034,0.061146893,-0.03581518,0.07824299,0.025382837,0.005109307,-0.09323241,-0.01746962,0.02664911,-4.532212e-08,0.037441984,-0.05788777,0.0676075,-0.016118065,-0.004104431,0.05678373,-0.019142702,0.014386722,-0.0062574926,-0.03738676,-0.052517854,0.068800665,-0.014571615,0.021555508,0.05673523,0.0037156362,-0.04621278,0.06538507,-0.010963483,0.020651013,-0.09036825,0.03131982,-0.13890174,-0.032344297,0.0034681975,-0.03945915,0.04060504,0.10523327,0.10151772,-0.044315565,0.03836179,0.025828036,0.024325548,-0.05942641,-0.10603437,0.012996957,-0.040114984,-0.05340242,-0.016320208,0.02797462,-0.09287455,-0.061050136,-0.018647427,-0.012054539,-0.029456649,-0.01140883,0.027765209,0.035829235,0.057871778,-0.01347881,0.029592821,-0.051539876,-0.0030800237,-0.0529489,-0.039389957,-0.032614507,0.00609746,-0.026779288,-0.03389104,-0.07290611,-0.04152021,-0.0020922702,0.15978776,0.0045753294 +2.1.1.156,"Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase. Differs from EC 2.1.1.20, glycine N-methyltransferase, as it can further methylate the product of the first reaction. Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction [3].",384,0.99999994,-0.040636063,-0.026654636,-0.14258695,-0.00031259924,0.009192051,0.1238958,-0.067593865,0.026829388,0.05230474,0.014379872,-0.005772072,0.032437928,0.00093627354,0.013153081,-0.048402563,0.073439375,-0.026025157,0.0060386336,-0.022560386,-0.033980146,-0.01027908,0.06556052,-0.027562762,0.008730759,0.01490532,0.020297516,0.05758233,-0.033881202,-0.01873522,-0.023249535,0.007688823,-0.050098687,0.038658854,-0.013886877,0.05604129,-0.0034989524,-0.0025880358,-0.058625672,0.052152652,0.040480513,-0.0048634927,0.04708778,-0.05229847,-0.017937806,0.006232962,-0.04084813,0.024566285,-0.017402468,0.039652,-0.068388715,-0.014410235,-0.06623817,-0.07157769,-0.006693411,0.03674684,0.0020967927,-0.18278411,-0.015815923,0.062116534,0.0002299043,-0.0059902137,0.0016413064,-0.002637095,-0.061811857,-0.020753749,-0.043723144,0.022122407,-0.13910668,-0.012669683,-0.04586543,-0.08407041,-0.08599469,-0.045229267,0.0055299285,-0.0364327,-0.0017280147,-0.00012994322,0.022611372,0.015175444,-0.043982778,-0.012916539,-0.03399857,0.012351837,0.009610573,-0.025754666,0.044908322,0.010499848,0.12997967,0.041359425,0.04836004,0.0037010247,-0.013071523,0.040330548,-0.022397757,0.018256968,-1.3929859e-05,0.047190655,0.055286877,0.041424427,-0.008537041,-0.0007886059,0.06144619,-0.07631806,-0.045443032,-0.001191461,0.02693106,0.055750027,0.092898056,0.0081327185,0.010062381,-0.00446844,0.039017286,-0.020429486,0.01575229,-0.043934647,0.099539675,0.027939463,-0.050054986,-0.07326525,0.06093374,0.07238537,-0.031114012,0.039572343,0.06251596,-0.042611334,0.07799593,-0.074934006,3.388311e-33,0.11610829,0.09776271,0.072898716,-0.0064636488,0.022690762,0.0015216299,-0.05993028,-0.00619261,0.087215655,-0.08111543,-0.077152215,-0.012441159,0.019565623,0.006525314,0.009464214,0.043558877,-0.05236577,-0.0153931305,0.08029244,-0.012493218,-0.04876869,-0.015922233,0.0026363195,-0.0033342948,0.012693721,-0.0072770435,-0.009176999,0.0010710522,0.08739103,-0.006885286,-0.051829863,-0.12081468,-0.035240263,0.0065824445,0.06807689,0.047421232,-0.029859804,-0.012518723,0.047688957,0.07935019,0.008266783,0.019374603,-0.0425585,0.016429912,0.0047413176,0.016219622,-0.049080476,0.013850737,0.010171378,0.022766937,0.021674754,-0.030162979,0.0891514,-0.02444798,-0.0048277457,0.01703655,-0.018721843,-0.0381438,0.010090759,0.068076804,-0.01989496,-0.017532025,0.014247738,0.0049905474,-0.0053940816,-0.025767792,-0.11565457,0.010785146,-0.058933783,-0.021666104,0.014826606,-0.070658214,0.135124,0.007317585,0.016384346,-0.059663244,-0.015748154,0.05112046,0.028781429,-0.05142152,0.052830953,0.09194237,-0.011084216,-0.053138852,-0.01806662,0.009531392,0.007559327,-0.05456292,-0.014011284,0.03551663,0.02114144,0.0022898351,-0.008779761,-0.024851622,-0.013670065,-3.854349e-33,0.077459455,-0.096542336,-0.035555307,-0.0732118,-0.0042645447,0.045544203,0.0019013042,-0.0867182,0.011305383,-0.0919034,0.042116027,-0.0021670484,0.057929467,-0.06165073,-0.030893058,-0.049442675,0.04532247,0.09816407,-0.036310904,-0.024422325,0.017004825,-0.016793786,-0.040286038,0.044492397,-0.051079605,0.016700383,-0.048875257,0.08155947,0.116252586,0.1100822,-0.026947076,0.04114568,-0.017505996,-0.07075552,0.0062702955,0.08482148,-0.0011612558,0.046107948,-0.021090878,-0.00033556097,-0.02297198,-0.02083644,-0.0172966,0.06894888,0.10950533,0.09634062,0.0470745,-0.008633352,-0.06466989,-0.06111887,0.036261503,-0.06384145,-0.024751386,0.06666466,0.03072689,0.06450425,0.02588735,0.025343642,0.07194981,-0.035523336,0.003998203,-0.045987353,0.020840403,-0.057620656,0.03591274,0.050178967,-0.012505348,0.035316173,0.04060975,0.041955378,-0.03211707,-0.06237733,0.02589892,0.047827464,-0.0074454593,-0.005526124,-0.076842554,-0.077548176,-0.058025673,-0.021434888,-0.042344876,0.058097124,-0.029387498,-0.057083666,-0.015120526,-0.013889964,0.07594696,0.10167522,-0.06820569,-0.012466497,-0.058085684,-0.01163128,-0.048034064,0.08162744,0.02381275,-4.4838735e-08,0.052244972,-0.10403556,0.023810249,-0.0023858238,-0.024946168,0.08153953,0.046762954,0.028236905,0.08097205,-0.10677184,-0.058393274,0.027770191,0.06559292,0.021428399,-0.027404359,0.0688628,-0.017673422,0.021150062,0.023042915,-0.029331617,-0.13671765,0.06796755,0.007416175,-0.0239479,-0.04897021,-0.06528034,0.033424865,0.08013131,-0.00793357,-0.020970255,0.028168414,0.053411968,-0.003840499,-0.06765397,-0.09965683,-0.05324487,0.060609814,0.01784806,0.08907326,-0.020141475,-0.03032703,0.054189272,-0.112371325,0.056777105,0.08678359,0.000730618,0.021778416,0.037254177,-0.05977228,-0.035401925,0.03627959,-0.021846442,-0.044358328,-0.12525888,-0.07785476,0.01777493,-0.043832548,-0.05034368,0.019161832,-0.05503354,-0.06249522,-0.0353575,0.122437365,0.005053069 +2.1.1.157,"Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. The first enzyme, EC 2.1.1.156, glycine/sarcosine N-methyltransferase, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme. Both of these enzymes can catalyse the formation of N,N-dimethylglycine from sarcosine [3]. The reactions are strongly inhibited by S-adenosyl-L-homocysteine.",384,1.0,-0.04115857,-0.0270679,-0.14564507,0.009529407,0.0021375387,0.13113002,-0.048592396,0.0024530988,0.040607832,0.04692858,-0.0017609507,0.030006135,0.016912542,0.030753404,-0.046545368,0.0888122,-0.035542842,0.0002976749,-0.018097661,-0.01695298,-0.010172469,0.050201733,-0.04127413,0.00096013886,0.029710812,0.01175569,0.070612624,-0.049518228,-0.05494398,0.0077385637,-0.0141083505,-0.052607823,0.046712566,-0.01099883,0.063328266,0.013641987,0.002072177,-0.054213583,0.069372594,0.0415168,-0.021161284,0.05521463,-0.060293876,-0.014939403,-0.030793298,-0.04678355,0.023754453,-0.028466646,0.06161435,-0.06529397,-0.02961343,-0.047603115,-0.08902741,-0.022021154,0.021750007,0.006119534,-0.17568289,-0.015663138,0.057185613,0.0038906862,0.009255087,-0.004440171,-0.002738853,-0.045784395,-0.010003738,-0.07176853,0.0060592606,-0.1141812,-0.008047507,-0.05103959,-0.07523914,-0.077030174,-0.049220014,-0.002121713,-0.049488615,0.0070641707,-0.009774434,0.018843023,0.0012971357,-0.03735259,-0.009482833,-0.024553986,0.020134509,0.02898287,-0.02135607,0.041726563,0.014392633,0.1294509,0.04846874,0.035417818,0.014358857,-0.0078035994,0.016500507,-0.010510569,0.01163594,0.0063855597,0.06894562,0.05003845,0.024083413,-0.015393226,-0.009713715,0.025515066,-0.054066982,-0.054429635,-0.0015361293,0.023529002,0.0413702,0.07606314,0.01830596,0.00251584,0.010946601,0.056642793,-0.045375027,0.0073929904,-0.03769664,0.11044048,0.02030916,-0.054769676,-0.1060807,0.07671268,0.045734677,-0.027250823,0.019221317,0.051765267,-0.042327456,0.058088142,-0.056119636,2.7083447e-33,0.11484357,0.1031668,0.06732026,0.0036346458,0.025631716,-0.018387757,-0.023980727,0.011495079,0.075883314,-0.0575617,-0.10943393,-0.0036430084,-0.0031096106,0.0036180154,-0.013713135,0.053376656,-0.052456472,-0.013957727,0.08032896,-0.0018862997,-0.057550266,-0.013977267,0.0037827094,-0.01637631,-0.0015054867,0.02556017,-0.0097438665,-0.016165953,0.08582114,-0.009836571,-0.03598465,-0.116457134,-0.0440062,0.009160299,0.0830971,0.038866658,-0.03997183,-0.0011473654,0.036172364,0.0772066,-0.0069730827,0.012942415,-0.061363656,0.0070880125,-0.006577937,0.033408545,-0.06754778,0.030020675,0.0045359572,0.028203238,0.025078211,-0.023789175,0.08823775,0.006946709,-0.014705395,0.009017295,0.0011734044,-0.048530813,0.014095318,0.06167064,0.012876997,-0.032904115,0.013411932,0.018763246,0.0076902066,-0.023038942,-0.104135044,0.021141635,-0.025001926,0.009169829,-0.0073404633,-0.07717237,0.10470751,0.018144757,0.007668202,-0.055609014,0.002861072,0.047991496,0.028635757,-0.04437262,0.07685933,0.09014262,-0.009879026,-0.05020283,-0.034019776,0.018513577,-0.016598709,-0.07211992,-0.0023613812,0.027467497,0.027782189,0.009750014,0.009133646,-0.029291209,-0.02760619,-3.9496555e-33,0.0921985,-0.11798525,-0.03659922,-0.083317965,-0.01898618,0.06087001,-0.010587683,-0.0848127,0.005287564,-0.055405524,0.041467983,-0.015665686,0.049392097,-0.043500777,-0.049354002,-0.030762805,0.067292966,0.11377746,-0.045356736,-0.04074761,-0.011668226,0.0061092754,-0.033846766,0.018160613,-0.059724756,0.0047608498,-0.055768386,0.065461904,0.10343674,0.123241626,-0.012369459,0.029598955,-0.025182048,-0.056074772,0.016894532,0.08819837,-0.015457264,0.034442168,-0.0028222587,0.024020774,-0.016511977,-0.036545753,-0.0055228546,0.090608545,0.1058737,0.058550917,0.017710688,-0.0061997864,-0.059099954,-0.06364434,0.048203364,-0.070326254,-0.024217295,0.01635692,0.025304357,0.07150238,0.032608442,0.0068177735,0.06919749,-0.044731557,-0.015980184,-0.049906064,0.020826895,-0.041331895,0.027599934,0.07820876,0.0009658154,0.01295454,0.030757535,0.02491935,-0.017291952,-0.07907106,0.020029603,0.055143427,-0.02235803,0.010862089,-0.062396143,-0.057821605,-0.06512887,0.0035008257,-0.035063133,0.063589066,-0.018624524,-0.0634312,-0.018654589,-0.021744786,0.08341753,0.09360745,-0.05922627,-0.007526639,-0.049191978,-0.012229904,-0.03336614,0.08038142,0.037507962,-3.9803357e-08,0.043868046,-0.09593026,0.018479412,-0.0066271806,-0.037049033,0.11064845,0.051196806,0.02233947,0.09510166,-0.09646478,-0.06765816,0.029391048,0.058816724,0.04333858,-0.022349369,0.08481919,-0.025621746,7.8003366e-05,0.02500127,-0.030972954,-0.14615515,0.06772604,0.0030136993,-0.011923939,-0.036475062,-0.06649131,0.00930896,0.07792522,-0.01697866,-0.006619033,0.025362829,0.056761518,-0.031325426,-0.062847644,-0.101555616,-0.051383357,0.055603564,0.013799558,0.08031324,-0.03912866,-0.03863116,0.07892515,-0.112580135,0.044162255,0.06318212,-0.0036513978,0.0071497182,0.033292763,-0.061591897,-0.013396161,0.03022008,-0.009797114,-0.043178707,-0.12613246,-0.08658225,0.020478219,-0.043246444,-0.05297668,-0.011353714,-0.07786307,-0.07351296,-0.029087871,0.12195813,-0.012632978 +2.1.2.1,"A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine.",384,0.99999994,-0.036854953,-0.09033945,-0.069152765,-0.074131995,0.04514389,0.092374936,-0.054020103,0.00069658464,0.032599982,0.03908553,0.014433706,0.07970018,-0.03646986,0.016673712,-0.014233965,0.03570884,-0.06005321,0.009678682,-0.017582798,-0.044178776,0.044967465,0.03878948,-0.022820456,-0.009515733,0.05620761,0.017916424,0.06671354,0.015644303,0.040347632,-0.038714807,-0.0037894053,-0.040641278,-0.018967692,-0.095621794,0.021320134,0.09556358,-0.08734518,-0.0034423375,0.1021079,-0.016985474,-0.0040407325,-0.052862287,-0.025797375,-0.04792379,-0.05205041,0.015572299,0.054090228,0.05289482,0.050408944,0.008425381,-0.012685202,-0.004088391,-0.08876537,-0.023777422,-0.018898636,-0.047646344,-0.10908723,0.017087026,0.016510207,-0.015776651,0.015719311,0.022574477,0.0067392215,-0.024190582,0.06622507,-0.07457074,0.00031527813,-0.0108261835,0.02709037,-0.009784091,-0.013193728,-0.026034946,0.043313373,0.00078872475,-0.020186849,0.029768338,-0.09517777,0.046547078,0.043037344,0.019468192,0.017693164,0.0028129376,0.009056071,0.13846439,0.03649703,0.02149529,-0.023410475,0.08215843,0.00918372,-0.051289324,0.015843313,-0.034114107,0.019886395,-0.02656639,-0.032689694,0.010176458,-0.039569017,-0.032038845,-0.00043451856,-0.0040782,-0.007163533,0.05647319,-0.023415655,-0.043768447,-0.047048945,0.039263997,-0.051101938,0.10396346,0.023561263,-0.013419669,-0.0596202,0.039200794,0.019527446,-0.0037064182,-0.037402622,0.080783226,0.038859077,-0.0320851,-0.04960781,-0.047130622,0.08263537,0.033672497,0.030213943,0.08990282,-0.030161686,0.047862526,-0.057972427,2.6343218e-33,0.10272147,0.12180015,0.06118016,-0.01242399,0.060359497,-0.013034102,-0.09854275,0.027862266,0.013653624,-0.006657593,-0.028781693,-0.043508902,0.0813472,-0.012880634,-0.05323136,-0.019618817,-0.06457429,0.043867096,0.06537783,-0.008717798,-0.0035670772,0.044020705,0.022319635,0.09175059,0.011182393,0.06565253,0.047651663,0.023242462,-0.005947401,-0.0051962244,-0.054770563,-0.12254129,-0.081174195,-0.05705159,0.030209383,-0.06731236,-0.098519415,-0.111524016,0.08455148,0.018323654,0.047685027,0.0016011416,-0.044083398,-0.0031324702,-0.011882331,0.00074549863,-0.018488351,0.060194217,-0.061541542,0.0026361134,0.09192548,-0.093642056,0.06680703,-0.029198373,-0.11803822,-0.008274514,-0.020646926,-0.038311396,0.012276064,0.083662294,0.06055181,0.024862645,-0.01045976,-0.0068745436,-0.019494038,-0.047873147,-0.03174511,-0.0017328096,0.029840695,0.060686547,0.007472091,-0.01530976,0.10096665,0.01102234,-0.013764798,-0.06542449,-0.05543717,-0.02713311,-0.0007903048,0.007296312,9.524763e-05,0.024620328,-0.041231524,-0.0139677115,-0.034736972,-0.012652351,-0.005737819,-0.13760954,0.0027098565,-0.0010451105,-0.007606962,-0.110588655,-0.019430501,0.017176058,-0.05152988,-3.0673757e-33,0.060178854,-0.108162485,0.056460608,-0.035878427,-0.02648163,-0.08003153,0.063519605,-0.04643918,0.015468892,-0.025884826,0.029773118,-0.05250953,0.030283643,-0.015087357,0.030084586,0.01876148,0.045057252,-0.004882754,0.03922931,-0.040577367,0.019621281,-0.019226696,-0.0025812907,0.03477157,0.05847392,0.06620342,0.0020313878,0.020127906,0.0551639,0.1101916,-0.008344109,-0.011692903,-0.007955375,-0.09591178,-0.030653307,0.080487385,-0.0011760648,0.0285734,-0.007946117,-0.057936467,0.04893304,0.008809314,0.05728726,0.087203026,0.030971061,0.021380655,-0.037932906,-0.003226717,-0.05913226,-0.059533175,0.07065521,0.013604046,-0.03003999,0.051332094,-0.019280324,0.06999708,-0.0068977866,-0.027583355,0.004868046,0.037160624,-0.0298227,-0.079491645,-0.023981571,0.022194851,0.024350123,0.034237493,-0.009026905,0.026295478,0.057550877,0.04190782,0.077098444,-0.0038106048,0.06942748,0.10354008,0.031525187,0.028757589,-0.036265276,-0.010654651,-0.0023136241,0.0012602005,-0.02776536,-0.005651167,-0.037109435,-0.030805988,-0.0013120376,-0.0695661,0.056879602,0.20154758,-0.030027973,0.030647947,-0.004582682,-0.012010755,0.016812589,0.07794955,0.06965035,-3.783832e-08,0.052684553,-0.11309162,0.03894451,-0.043814994,-0.027366647,0.04223584,0.0296972,0.030163541,0.013103651,-0.06205195,-0.03481271,0.009582544,-0.0117231915,-0.06069992,-0.033326652,0.108972855,-0.04830066,0.07307524,-0.049282964,-0.039254107,-0.06831201,0.06844259,-0.08817411,0.0034251618,-0.005579653,-0.04088742,-0.038574666,-0.013348872,0.003374764,-0.00923268,0.04275915,0.03213023,-0.006238892,-0.117451645,-0.06516299,0.029852554,0.0025130939,-0.036839414,0.042251203,-0.052253872,-0.06527238,0.057338487,-0.07546002,0.0027620303,0.0198787,0.017749585,-0.052815653,0.00930883,-0.07294612,0.036433443,0.05670222,0.010633387,-0.004347017,-0.08503112,-0.100573875,-0.011225381,-0.060053274,-0.058597527,0.034904692,-0.08387486,-0.052694462,0.010471928,0.19212493,-0.009899292 +2.1.2.2,"Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine---glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase.",384,1.0,-0.039331544,-0.04648919,-0.12812527,-0.0940365,-0.036256615,0.07045978,-0.062973924,0.024257908,-0.009198941,0.038127705,0.052547984,-0.050897,-0.043228295,0.03529875,-0.0042478996,-0.009776056,-0.15982056,0.0029097327,0.009486363,-0.030922644,0.06589517,-0.022339618,-0.06440183,0.037289973,0.0535972,-0.02917627,0.070689455,-0.018878696,-0.005084716,-0.048773993,-0.037624355,-0.09455485,0.021201389,-0.08334061,0.11214697,0.039307073,-0.06257084,-0.01643534,0.031062977,0.011338303,-0.02112172,-0.054815393,-0.03144335,-0.006569053,-0.026654223,0.005321269,0.08095862,0.043401647,0.02557076,-0.047893874,-0.030501422,-0.020718565,-0.03669359,-0.022159996,0.01962697,0.01107223,-0.124037646,0.01273874,-0.022780074,-0.008232441,-0.059244856,0.019665578,-0.042181365,0.021947736,-0.0066471715,-0.03373318,0.06404642,-0.08794615,-0.0045877076,-0.087136984,-0.054044306,-0.11207726,0.015323426,0.010286334,-0.020193482,0.065135874,-0.0106595475,0.020050785,-0.011538231,-0.016519818,0.015484343,-0.064496726,0.019302117,0.05811952,0.020182354,0.0018150371,-0.021611141,0.006231475,0.0040254495,0.024128877,0.063269824,-0.0017389456,0.06971254,-0.06599157,-0.016983097,0.07678248,-0.02435297,0.10228096,0.13026576,-0.033572026,0.009246624,0.101912566,-0.060085833,-0.06019686,0.03669154,0.009302503,0.00924463,0.10447142,0.035331573,-0.0054707304,-0.05558104,0.011845699,0.016603794,0.03890178,-0.0027568194,0.13393599,0.001628671,-0.08316573,0.015472732,0.0076416,0.04532962,-0.021423448,0.044294544,0.053725213,-0.03269413,0.050502658,-0.054437336,5.360506e-33,0.026457319,0.10586354,0.027543541,-0.010750214,-0.023886895,0.019904768,-0.0994964,0.05030061,-0.038085695,-0.053710077,-0.06501084,-0.027876966,0.04039645,0.023460792,0.021383855,-0.06552347,-0.024172414,0.064637296,0.05966829,0.055021793,0.030766029,0.07322928,0.037853237,0.011160959,0.07061581,0.056996875,-0.029539976,0.048712578,-0.00917441,-0.009946068,-0.060867544,-0.13391362,-0.04369053,-0.01531347,0.0028268618,-0.07182349,-0.006693184,-0.07524747,0.016672026,0.07496928,0.018086858,-0.044647824,-0.022363778,0.007919843,0.045919836,-0.003126099,-0.06538917,-0.0041724355,-0.0067039956,0.044632025,0.023096817,0.008891687,0.12590666,0.024285225,-0.019065825,0.01696517,-0.0271456,-0.07837438,0.029077696,0.040413436,-0.0038791639,0.11247674,0.0014324724,-0.036637742,-0.013994773,-0.059162285,-0.058832914,-0.00036014666,-0.018445782,0.074422255,-0.023327716,-0.024829755,0.042678528,-0.04526349,0.095844075,-0.058227845,-0.027639322,0.0026235897,0.018557651,-0.026399292,-0.004374609,0.06636458,0.011215621,0.04654415,0.050622452,0.011872462,-0.022592787,-0.062166348,-0.037839822,0.08249596,-0.008057532,-0.07096101,-0.056967903,-0.01994093,0.03850747,-6.0752134e-33,0.06950846,-0.08854125,0.025195928,-0.10859346,-0.03931532,0.041825544,0.06344351,-0.039293043,0.11451643,-0.022419354,0.015944336,-0.012786726,0.087580785,-0.10196054,-0.023259828,0.0023081203,0.017777763,0.07212294,0.026443016,-0.022674987,0.050752908,0.034318622,-0.048723202,0.017949315,0.07984197,-0.00526648,0.013369221,0.101529606,0.05578933,0.03094391,-0.039089218,-0.027779005,0.02566308,-0.022098802,-0.031693313,0.088357896,-0.07821135,0.04374072,0.004476714,-0.036687817,-0.029452726,0.0467796,0.0057088896,0.031949595,0.040354643,0.07177687,-0.049191732,0.046784606,-0.013399994,0.0023026809,0.070664294,0.012270077,-0.0127736265,0.039820496,0.025753599,-0.0014381799,0.019567203,0.016053665,-0.026149377,0.020507704,-0.0106375655,-0.05431635,0.008592886,0.013406731,0.06596481,-0.0061818208,-0.010427195,0.03826229,-0.009988934,0.012712543,0.052784298,-0.020895468,-0.026005683,0.048061628,0.0047536036,0.0169223,-0.07077503,-0.01772833,0.04462806,-0.0115860775,0.00081041304,-0.04854631,0.03818251,-0.023402175,-0.005680679,-0.029442457,0.06345581,0.0685961,0.0022041907,0.038994417,-0.014486172,-0.015215563,-0.0040102387,0.055771545,0.013038554,-4.7392152e-08,0.08627666,-0.13272032,0.015163363,-0.13762622,0.022378787,0.014905787,-0.048447035,-0.024199184,0.02214268,-0.09970156,0.0034758998,0.0013025176,0.06001029,0.02071226,0.026544046,0.0442969,-0.025248077,0.0055158646,-0.033718172,0.002466772,-0.113082886,0.033036254,-0.13899615,0.043580644,0.02128096,-0.0029080433,0.03752373,0.053063266,-0.0223701,-0.009407001,0.018213147,0.009072588,-0.045057308,-0.013771212,-0.039824676,0.0016297542,0.009220111,-0.040860817,-0.018938668,0.037970454,-0.021677509,-0.06343687,-0.07319154,0.036612567,-0.007892157,0.0028110435,-0.0042669154,0.02172043,-0.01805221,-0.027556883,-0.016067807,0.00387919,-0.012396591,-0.12898356,-0.05592341,-0.022624912,-0.033698246,-0.0945415,0.027530637,-0.014940928,0.034097783,0.041694045,0.2470466,-0.0374241 +2.1.2.5,"The enzyme also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate. In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.",384,1.0,-0.05183209,-0.06709711,-0.053621367,-0.044186562,0.00048651104,-0.0010468322,-0.06013445,0.05616401,-0.008994401,0.021251451,0.039908167,-0.06617456,0.013143241,0.064937614,0.015974917,0.035481054,-0.13616759,-0.0052902955,-0.023163078,-0.08047439,0.09951008,0.0491569,-0.057555467,-0.026518017,0.057194185,0.047398176,0.026728041,-0.042789806,0.07487709,-0.055314448,-0.031691182,-0.031342346,0.04910213,-0.011669207,0.006375266,0.073187985,-0.116827674,-0.0851303,0.056704883,-0.0432909,-0.03137565,-0.00032575606,-0.009787107,-0.043420635,-0.055327207,0.044468082,0.04856204,-0.022070108,-0.024656711,-0.034288928,0.0012834686,-0.042847354,-0.014662321,-0.0025593461,-0.024668185,-0.0032768736,-0.03637204,-0.02029307,0.03925707,0.029849287,-0.00052627135,0.08759751,-0.043364827,0.004672317,-0.022440622,-0.053814016,0.04807576,-0.06516089,0.0019122141,-0.055612296,-0.042308066,-0.085389934,-0.027704008,0.034510717,-0.0011576554,0.018806951,0.03347347,-0.028896878,-0.023552047,-0.017547712,0.04266487,-0.010750525,0.024288127,0.007110351,0.01575788,-0.026129643,-0.025811661,0.02011922,0.054425407,-0.019932844,0.042508308,-0.0031914092,-0.09141923,-0.036601536,-0.10413877,0.021602511,0.01843328,0.068869725,0.095045336,-0.023300104,0.04849587,0.07455616,-0.022754537,-0.02284507,-0.05300159,-0.01579775,0.053630225,0.072006054,-0.0016665263,-0.039968137,-0.025951568,-0.02075982,0.01975615,-0.0027639163,-0.014240734,0.060460478,0.0082435105,-0.049745183,-0.062055197,0.052562423,0.022916045,-0.016987348,0.06760935,0.037236333,-0.040002726,0.05058411,-0.115399994,3.6992095e-33,0.047268707,0.055550728,-0.011718875,-0.00230993,-0.012142574,-0.018746099,-0.06984776,0.052808005,0.028514521,-0.06100201,-0.09124588,-0.028772041,0.08035028,0.01562902,-0.016483303,0.009156743,-0.025385965,-0.013350402,0.03806535,0.028805673,0.072432585,0.010539659,-0.0055153985,0.009295799,0.035227973,0.045227524,0.025831534,-0.0006275378,0.04543614,0.008246218,-0.06414718,-0.17958358,-0.10457636,0.0034676387,0.08142835,0.04706254,0.006249817,-0.055447683,0.01841862,0.040646695,0.0012849555,-0.05264829,-0.02171302,-0.009359817,0.040600214,-0.0047850376,-0.08434961,0.0804376,-0.017570386,0.05398014,0.072290234,-0.08065275,0.07656181,-0.005337947,-0.052658454,0.08408905,-0.018949645,-0.06651788,0.037649356,0.07774717,0.008766286,0.057057943,-0.07610477,-0.018365405,0.033636086,0.02711279,-0.023423318,-0.07384649,-0.026382638,0.050707262,-0.08339314,0.0021500583,0.077451356,0.063026674,0.060287885,-0.051047567,-0.055528592,-0.02375682,0.05230904,0.033262003,-0.05709787,-0.026743663,0.040278874,-0.021772204,0.05110509,-0.029933695,-0.01307002,-0.09145622,-0.08935364,0.016441982,0.0532851,-0.119282745,-0.0031895451,0.0028618365,0.012972588,-5.112858e-33,0.105789416,-0.08507336,0.012418756,-0.09918434,0.009710415,0.03800632,0.008196019,-0.03772761,0.0010874815,0.005790263,0.027463008,0.01686932,0.07561577,-0.0047650794,-0.005276779,-0.05603699,0.03463451,0.11305484,0.029356359,0.014130752,0.0055497033,0.034367815,0.00865739,0.006896332,0.08388911,-0.013915354,-0.016822858,0.03810538,0.056877386,0.04441875,-0.054045115,-0.0039841575,-0.0006042689,-0.051829603,-0.0022985125,0.11197913,-0.050067246,0.005579768,-0.010928644,0.013234992,-0.012651702,0.07720411,0.057639144,0.030216603,0.0073086102,0.06777554,-0.08140025,-0.022818426,0.012094144,-0.073736094,0.08892286,0.028084058,-0.030867914,0.0037430576,0.04400717,0.06538144,0.072127886,0.011637768,-0.0057782703,-0.027862094,-0.062151827,-0.080561645,0.017625913,-0.050506163,0.075777575,0.033179455,0.05121994,0.037229583,0.03399398,-0.03605337,0.04412674,-0.02610725,0.014173074,0.019438414,-0.06733663,-0.006560065,-0.015778288,-0.043120414,0.024213921,-0.06449896,0.078079134,-0.041980468,0.041346643,-0.062126257,-0.0107124075,-0.13639492,-0.0023927337,0.12383215,0.0298531,-0.015570031,-0.052954752,-0.0006929551,0.044379774,0.054521453,0.078762144,-3.9714156e-08,-0.016736751,-0.019341158,-0.015101988,-0.055456556,0.071936205,0.070464246,-0.017210664,-0.050274264,0.047068447,-0.04372863,-0.007008771,0.037883844,-0.0016432009,0.014342832,0.010950067,0.047380332,-0.018945286,0.04450213,-0.0057807015,0.012665107,-0.071762085,-0.028787918,-0.12264569,0.03302631,0.03467621,-0.07610545,0.046487775,0.05074729,-0.000639595,-0.040694874,-0.046428997,0.06290241,-0.031781342,-0.037867304,-0.09149951,-0.009951294,0.01940815,-0.021120396,-0.046499476,0.073193744,0.0056908433,-0.0065455292,-0.08371187,0.02478635,-0.010412394,0.033926386,-0.012497076,0.01968304,-0.006588916,-0.034390457,0.031422384,-0.04321035,0.022515098,-0.045631964,-0.08342765,-0.010359063,-0.038179208,-0.06983728,0.0242071,-0.05733179,-0.0021895075,0.09079812,0.26188707,0.010111449 +2.1.2.7,Also acts on 2-hydroxymethylserine.,384,1.0,-0.014423975,-0.10850343,-0.012437523,0.009103644,0.03826488,-0.016488945,-0.0095600765,0.017487958,0.05659335,-0.028640268,0.07050316,-0.042551175,-0.060796294,0.059611768,0.014935518,0.11514157,-0.10850353,-0.0024828138,-0.006063447,0.004306542,0.053976007,-0.008327906,-0.008664698,-0.010472059,-0.046536155,0.034257762,0.005074962,0.061856586,0.026547285,-0.06049783,0.056425124,0.06894752,-0.09014598,-0.005066361,-0.014156685,0.017891359,0.0032704447,-0.03234348,-0.0070439577,0.025966303,0.08597278,-0.06887481,-0.020332327,-0.031119723,-0.012078756,-0.017780537,0.033225372,0.012032509,0.0386233,0.021195807,-0.0037224423,-0.057703696,-0.036889207,0.04675039,-0.028415922,0.01959712,-0.07050972,0.028591365,-0.0065559647,0.031783577,-0.0033847468,-0.0019346315,-0.0450249,0.051019054,0.053885765,-0.04793435,-0.0071651903,-0.09943467,-0.014599442,-0.055685073,-0.01326242,-0.07224497,0.05706865,0.0010809138,0.0059600687,-0.050444912,-0.046012692,-0.06796163,0.036311653,-0.025114395,-0.037750334,0.010919826,0.029870542,0.09520001,0.06742939,-0.020198729,-0.017489072,-0.037104797,-0.05655872,0.04767662,-0.011832038,0.006989008,0.0076909335,0.038801514,-0.058258224,0.024948547,0.04719008,-0.009215212,-0.016236873,0.007441808,-0.08045317,0.023431651,-0.12212689,-0.06699046,-0.03129802,-0.023751445,0.017564848,0.035923984,-0.032933194,0.0050816685,-0.025834303,0.01902091,0.003326318,0.025139995,-0.067069195,0.10979841,0.08751762,0.026803996,-0.03313872,-0.09757473,-0.025256455,-0.040221117,-0.012539707,0.02270415,-0.07892176,0.05291896,0.008092035,-1.4276433e-33,0.051705286,-0.023228254,0.0478649,0.011456956,0.013147183,0.0025181281,-0.07823177,0.003720359,0.038550932,-0.063993655,-0.025336666,-0.0336572,0.05717005,0.028817423,-0.030239927,-0.07642758,-0.025800385,0.008257704,0.065584235,-0.061943255,0.025711171,0.09462629,-0.043269124,-0.009761992,-0.063904114,-0.03013064,0.02940824,0.0038233192,0.07344576,-0.0036933653,0.013949387,-0.045494184,-0.05269377,0.03799153,0.024856752,0.08705033,-0.07902037,-0.010058606,0.034962386,0.051064502,-0.008788977,-0.0025764098,0.026574897,-0.059434548,0.045825657,-0.049723774,-0.07406358,0.065854184,0.058006708,0.030828562,0.03856924,-0.019140707,0.07772171,-0.006977657,-0.022324027,0.034180444,0.015823526,-0.011859125,-0.035876807,0.05530715,-0.07094242,0.01841371,-0.042539403,-0.02068527,-0.012040142,0.03157168,-0.054692924,-0.04847618,-0.05999822,0.025579883,-0.09194717,0.046447825,0.1694137,0.022410236,0.05533522,-0.0069364533,0.00079812796,-0.0057860143,0.032376043,0.07292422,-0.0014994941,-0.03867719,0.07558357,0.011325356,-0.08028193,-0.025760582,0.002528674,-0.0697229,-0.017435454,0.01992322,0.08661936,-0.09432095,-0.049636226,-0.037303012,0.02560952,-1.5613441e-33,-0.0019163464,-0.08868898,-0.011738343,-0.035339326,0.033279248,0.035261627,0.00024819357,-0.027963921,-0.016858514,0.0074763354,0.13979603,0.05753044,-0.08547935,-0.022257917,-0.011501158,-0.022633832,0.019765817,0.07471968,-0.031940736,-0.005358614,0.009083591,0.11281157,0.061129406,0.1136839,0.05933812,-0.0005794557,0.039233837,0.0089174425,0.01579747,0.09482394,-0.027800513,-0.050559465,-0.06120247,-0.045513522,0.04879181,0.018079426,-0.017195417,-0.04453464,-0.08304842,-0.012623616,-0.008570812,-0.058828246,0.06143013,0.10562192,0.061119545,0.11197472,-0.028992089,-0.010239229,-0.09014298,-0.010229448,-0.041840997,0.0143909445,-0.050289262,0.051305756,0.06597273,0.038815036,-0.011840605,-0.062932454,0.005503238,-0.034946576,0.0021636635,-0.0025794944,-0.01644472,-0.09358747,0.022629978,-0.015207954,-0.049926404,0.0417897,0.07850765,0.020982446,0.12525377,0.04352874,0.0005074665,0.021723654,-0.073091574,-0.07664296,0.015192164,-0.15256254,-0.053247686,-0.028474549,0.0061183334,0.013445287,0.009254288,-0.07560956,0.011880753,-0.09094912,-0.004898912,0.05916702,-0.05178161,0.02718168,-0.0018186825,0.056539986,-0.059431575,0.03921971,0.05354813,-1.9478604e-08,-0.01192953,-0.045560874,0.080291614,-0.06097343,-0.05625245,0.009209053,0.03277382,0.051523637,0.060554262,-0.068675235,-0.021167455,0.0828747,0.07233772,-0.00023573574,0.062487517,-0.029876178,-0.0071340543,0.0134359,-0.06567143,-0.078500144,-0.13121577,-0.034567844,-0.055957023,0.023469614,-0.03418535,-0.023016157,0.036168724,0.07626356,0.036432162,-0.02697641,0.10070846,-0.0109495055,-0.0069154133,0.014941243,-0.07863772,0.035961617,0.0023465073,-0.0063497135,-0.024443865,0.023294417,0.0026480183,-0.0055994336,-0.0546895,0.080677435,0.08284824,0.051863454,-0.03265421,0.043200836,0.0061956863,0.029016696,0.062297255,-0.026024217,0.013084114,-0.011759303,-0.12813184,0.015457247,-0.055774204,-0.057500444,0.032534827,-0.03605467,-0.0014194392,0.018778604,0.18890487,0.06544282 +2.1.2.10,"A component, with EC 1.4.4.2 glycine dehydrogenase (decarboxylating) and EC 1.8.1.4, dihydrolipoyl dehydrogenanse, of the glycine cleavage system, formerly known as glycine synthase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein [3].",384,1.0,-0.031935655,-0.029673329,-0.06449251,-0.10077289,0.040235534,-0.01745989,-0.08173628,0.042816218,0.020480169,-0.011306415,0.049794614,0.020042997,-0.048426572,0.0034127242,-0.03674196,-0.04662603,-0.031637076,0.00667904,-0.001213363,-0.06193337,-0.008014484,0.061429273,-0.07165986,-0.005110885,0.018879661,0.04861245,0.03768968,0.009385025,0.0007549238,-0.06438129,0.009260684,-0.07681727,0.051673397,-0.046025425,-0.03668853,0.09749396,-0.03095126,-0.04983915,0.061604794,0.04035599,0.044426918,-0.012541006,-0.040006988,-0.03175889,-0.015532397,-0.008462471,0.028454281,0.054804683,-0.012150772,-0.010478286,-0.027259566,-0.022186607,-0.021197366,0.014609564,-0.01481615,0.0013645818,-0.057840273,0.076548494,-0.07362959,-0.026905758,-0.054816164,0.030316832,0.009532805,-0.00819289,0.01621377,-0.037209496,0.07778867,-0.05100802,0.02630011,0.012698913,-0.06094956,-0.06736467,0.008296441,0.023559326,-0.08921973,0.10988736,-0.062098853,0.022187576,0.055867884,-0.02825093,0.037072882,-0.008287191,0.029520325,0.04192523,-0.0073032174,0.013894785,-0.04091159,0.0076559563,0.016480252,-0.0027603162,0.011213597,-0.06640939,0.024499852,0.026462648,0.01176362,0.072609074,0.03661729,-0.02898055,-0.012963087,-0.059911534,-0.051235653,0.06543018,-0.021071836,-0.016508609,-0.045317292,0.017447626,-0.034719493,0.061648432,-0.037018135,-0.02561039,-0.005663408,-0.025931902,0.047517378,-0.0075874617,0.041781075,0.050684087,0.03969853,-0.0011710147,0.017052164,-0.054131318,0.05672616,-0.014133684,0.092527285,0.088372365,-0.008769427,0.0593585,-0.11358342,-3.8393866e-34,0.0728934,0.03787009,0.006813848,0.038031623,-0.027916862,-0.015299885,-0.09726693,0.073196836,-0.018584471,-0.006737309,-0.06812499,-0.060265284,0.07179744,0.0045659216,-0.009881166,-0.015560971,0.01449656,0.03673859,0.013828993,0.020548997,0.013955142,0.042732425,-0.0030495103,0.0026700406,0.047798913,0.06952096,-0.017630309,-0.034897726,0.0010604905,0.006173329,-0.09026023,-0.14777732,-0.043518387,0.028451787,0.026319923,-0.059501637,-0.036485277,-0.0731421,0.09446804,0.043608654,0.053804677,-0.069984615,0.008907209,-0.068672754,0.013069553,0.065461084,0.00047192076,0.014168284,-0.018707115,-0.040990938,0.087552994,-0.037798144,0.09158691,-0.043889597,-0.10734793,-0.0036318563,-0.026230978,0.024500461,0.006983202,0.14435512,-0.023694308,0.081767514,-0.03236831,-0.03576323,0.017205851,-0.004357937,-0.1408844,-0.029101495,-0.011457267,0.058841195,0.019238308,-0.064948864,0.15105835,0.023146175,0.029575013,-0.0059007313,0.015918942,0.050623555,0.01968145,0.039725978,-0.04695869,0.10862528,-0.045512296,-0.0669144,-0.041627362,0.0036333075,0.017917406,-0.11183851,0.005100127,0.046163242,-0.023734892,-0.040350847,-0.030283356,0.007192446,-0.023216743,-1.5251467e-33,0.023439456,-0.09718008,0.031122142,-0.04157591,-0.013643999,0.05785232,-0.0030477692,-0.0033565196,0.055458333,-0.021103485,0.055830106,-0.025211848,-0.046504993,-0.07491215,0.00021782739,0.04820457,-0.03812508,-0.0043044244,-0.0148063935,-0.07756811,0.014605783,0.025400532,0.07006069,-0.008804076,0.06486331,0.024379548,0.033826284,0.07891202,0.037982605,0.08353503,-0.055698026,0.043711916,-0.014933033,0.02287822,-0.09818647,0.09919706,-0.088708386,0.0104604615,0.018566335,-0.054606084,-0.0029327425,0.033707697,0.02833786,0.05788064,0.058977086,0.050088245,0.0038336343,0.016948922,-0.0010137748,-0.033110667,0.022605151,0.005952216,-0.002303896,0.08686068,-0.023113405,0.07376567,0.058517713,0.06411224,0.026808595,0.012987303,-0.014020765,-0.07982474,0.033857968,0.07440759,0.032215547,0.0061174016,0.018988863,0.045221247,0.08502507,0.016649611,0.07029927,-0.03544379,0.042014677,0.07197955,0.05935281,0.0464623,-0.082987025,-0.027856993,-0.009319768,-0.08190323,-0.08200584,0.0054663853,-0.041476052,-0.056083955,0.046804175,-0.07539515,-0.008571299,0.16567458,-0.00087106053,0.02603662,-0.013205895,-0.020264698,-0.0857169,0.13253275,0.06947692,-4.4975927e-08,0.059142485,-0.06360384,0.022817016,-0.041718476,0.020285934,0.08484842,0.015917988,0.040031753,0.060020354,-0.053690966,-0.011110659,-0.014724868,-0.031086663,-0.020159243,-0.04413695,0.09343168,-0.10181626,0.0670897,-0.02786608,-0.022214405,-0.026229018,-0.0032350158,-0.116327405,0.010077965,-0.022766331,-0.058070462,-0.06161821,0.033099588,0.011814996,-0.02359414,-0.0028829349,0.046917524,0.01871392,-0.023284938,-0.011671851,-0.031905945,-0.03696736,-0.00078557944,-0.06699837,0.048056524,-0.039468806,-0.040154025,-0.039333418,0.02664005,0.010044656,0.01890353,-0.045318276,0.05930868,-0.011084993,0.0008824173,0.022727877,0.055245813,0.013628485,-0.08474805,-0.11757192,-0.03601178,-0.07513805,-0.07943208,0.012528837,-0.040426247,-0.07247785,-5.803747e-05,0.18537544,-0.0038309419 +2.1.3.1,"A biotinyl-protein, containing cobalt and zinc. The enzyme, described from the bacterium Propionibacterium shermanii, is unique among the biotin-dependent enzymes in that it catalyses carboxyl transfer between two organic molecules, utilizing two separate carboxyltransferase domains. The enzyme is a very large complex, consisting of a hexameric central core of 12S subunits surrounded by six 5S subunit dimers, each connected to the central core by twelve 1.3S biotin carrier subunits.",384,1.0,-0.08173283,-0.016339565,-0.13133912,0.036374528,0.07925384,0.062386654,-0.049593605,0.07725136,-0.011357505,-0.095781766,-0.054285213,-0.03432879,-0.03968176,0.026945423,-0.0642956,-0.010270162,-0.11610976,-0.009067456,-0.001256625,-0.03277363,0.028333558,0.027160704,0.008496202,0.042031445,0.013068211,-0.012948314,-0.009289889,0.009527215,-0.0072754277,-0.0026441654,-0.010470622,-0.035353146,-0.02313755,0.027797958,0.057964366,0.041889004,-0.039007045,-0.05294744,0.035396755,-0.032782566,0.046397436,0.047821864,-0.0059634545,-0.045066997,0.014152535,-0.020367008,0.01650405,0.0050247987,0.04588213,-0.033058047,-0.106966846,-0.047077797,-0.02792378,0.03379243,0.075782284,0.01840081,0.005698686,-0.106664054,0.025384339,-0.039857812,0.12168732,-0.04225152,-0.01195492,-0.03081146,0.026850903,-0.08942981,-0.042125955,-0.016345177,0.03293653,-0.041444097,-0.05160851,-0.06243552,-0.028504023,0.043089334,-0.0037113293,0.0054644695,-0.01716888,-0.03810522,0.03570829,0.013730445,0.007307953,-0.01199765,0.009400829,0.10569727,0.008455864,-0.0317599,0.055456385,0.06386638,-0.05710153,0.03573485,0.014061372,-0.042882167,0.06454696,-0.015139596,-0.12595932,-0.041845307,0.017326394,-0.013436121,0.050451417,-0.0061437637,0.030498514,0.023281896,0.023945985,-0.11954473,-0.057174478,-0.014269258,0.017882535,0.20294227,0.07435375,0.008659648,-0.04028629,0.011469909,0.008175843,0.04477402,-0.054561123,0.049379244,-0.0068176663,-0.037810724,-0.04324751,0.057449628,0.05524412,-0.0007516133,0.018281486,0.026292296,0.016220167,0.009554923,-0.09363802,4.7932935e-33,0.08706652,0.023789115,-0.009307029,0.045500506,-0.0018307351,0.038866546,-0.10693511,-0.03160353,0.012738768,-0.00046611959,-0.09221236,-0.009748152,0.011392359,0.048139557,-0.032456443,-0.060951773,-0.08227818,-0.035921715,0.08854526,0.07148586,0.030454962,0.13105191,-0.09154672,0.035750072,0.053556025,-0.009735264,-0.05329095,0.018235903,0.02476008,-0.0070132646,0.044569314,-0.08182947,-0.105753124,-0.013554069,0.15306593,-0.06559066,0.03341674,-0.06525024,-0.0038294264,0.058458038,0.060454313,-0.0060365684,-0.037110317,-0.0032260737,0.086251006,-0.040838245,-0.03345297,0.07411949,0.03679588,0.040930755,-0.0026800993,-0.008229377,0.0809484,-0.09094751,-0.08185723,0.059017733,-0.059126608,0.050567552,0.07590007,0.050323136,0.03874022,-0.01682859,-0.027000282,0.029515209,0.04131777,0.03676581,-0.12394813,-0.02080675,0.009855712,0.10204712,-0.082388714,0.032143,0.06376519,0.032316335,0.007621682,-0.05642588,-0.09225539,-0.052427758,0.012647561,-0.010929828,-0.0997691,0.020668685,-0.0068621165,-0.020082844,-0.044119153,-0.010032427,-0.057057764,-0.055883333,-0.03488038,-0.016421601,-0.01608745,-0.07220437,-0.04716472,0.016250711,-0.047546145,-6.694713e-33,0.047273934,-0.09027119,0.105261266,-0.04220997,-0.020596322,0.02808799,0.018240247,-0.011337908,-0.0074458136,0.0018577033,0.094697304,0.0009869244,0.092442065,0.006649296,0.04384363,0.02840881,-0.03637534,0.014194648,0.023304299,0.003386211,-0.017372265,0.005957903,0.018226562,0.011218343,-0.04388853,0.06085387,-0.073470205,0.047034528,0.10344615,0.031792052,0.01806891,0.02187142,-0.030052677,-0.11379469,-0.08228193,0.02915218,-0.018284608,-0.036712687,0.034124937,0.019194512,0.021948818,-0.07378287,-0.08433725,0.040980056,0.10473051,0.009186015,-0.07026834,0.0017290362,0.007020197,0.0020502866,0.034873776,0.0285467,-0.009358922,-0.018665155,0.012191416,0.0074802055,0.05841236,0.021210844,0.091164656,-0.017238805,0.05908023,-0.05571179,0.05347599,0.051944178,-0.03725683,0.013743217,-0.005961086,0.037491944,0.05443317,-0.03939933,0.09063716,0.0766022,0.05751952,0.02933337,-0.011437731,-0.03370431,-0.01504036,-0.028386159,-0.012761304,0.0157785,-0.02847786,0.013611501,0.03892149,-0.089230426,0.037315648,0.0035205309,0.048973016,0.06682078,-0.04674269,0.01883712,-0.03458961,-0.017206961,-0.016724223,0.00745536,-0.09501495,-4.7944837e-08,0.07475349,-0.094307795,0.048405938,-0.05176413,-0.047781806,0.037637573,0.017974326,-0.049998164,-0.013560976,0.008910245,0.047603454,0.0618532,-0.10541321,0.0127712935,-0.00661213,0.022302384,-0.05327189,-0.02594087,-0.009875592,0.010699189,-0.036363173,0.026988847,-0.05041917,0.06445415,0.012801384,-0.047231067,-0.01135019,0.055320915,-0.033382833,-0.06527866,-0.02769153,0.052908506,0.025338233,-0.014429485,-0.0863459,0.002929748,-0.02504708,0.0015560682,-0.044119805,-0.0014736461,0.061645765,-0.03533215,-0.07907325,-0.008193767,0.035599515,-0.054488376,0.03031598,0.08433096,0.022427598,-0.0025888176,0.03778127,-0.022358965,-0.05513626,0.018632144,0.007222179,0.018675486,-0.028563086,-0.07479625,-0.030038731,-0.005168825,-0.009427067,-0.02089428,0.13068199,-0.068144344 +2.1.3.3,"The plant enzyme also catalyses the reactions of EC 2.1.3.6 putrescine carbamoyltransferase, EC 2.7.2.2 carbamate kinase and EC 3.5.3.12 agmatine deiminase, thus acting as putrescine synthase, converting agmatine [(4-aminobutyl)guanidine] and ornithine into putrescine and citrulline, respectively.",384,1.0,-0.10411695,-0.021281578,-0.06379997,-0.03061265,0.045992073,0.12346748,-0.10259763,0.07475534,0.05323665,0.018403854,0.07191288,-0.06724267,-0.037081167,-0.077316046,-0.053067017,0.044297356,-0.07909605,0.06798872,-0.030589031,-0.058190163,0.018669987,0.046527993,-0.04936818,-0.02447001,0.05837485,0.014019505,-0.016831461,-0.008952057,0.0015201733,-0.05424582,-0.033450067,-0.07788176,0.04015102,-0.023024824,0.030821329,0.010438473,-0.049578063,-0.06868851,0.03796036,-0.023326434,0.05410205,0.018009134,-0.02921532,-0.065389104,-0.011813372,-0.021529831,0.052019607,-0.009891,0.026882796,-0.07825206,-0.010387195,-0.025020545,-0.0376048,-0.05774053,-0.011661675,-0.035622332,-0.043562178,0.020977244,-0.009858659,0.07630356,0.052395247,-0.0438577,0.011874462,-0.047828678,0.033991247,-0.023786576,-0.016377695,-0.041764345,0.011413572,-0.023430916,-0.054226276,-0.09051869,0.022649866,0.076718,-0.031318214,0.034658175,-0.08857831,0.052017443,0.0650096,-0.0050765965,-0.014199852,-0.024085633,-0.050779786,0.020028016,-0.032133285,0.017197084,0.029332824,0.12825422,0.063047454,0.00966584,0.02409282,-0.037524823,-0.031323057,-0.0075231115,-0.05785228,0.09739024,-0.015573048,0.02836582,0.04651843,-0.06030031,0.030643584,0.08788423,-0.06076367,-0.08424827,-0.06910026,0.035908483,0.011429863,0.05544259,-0.011431737,0.014836999,-0.02244423,-0.02634397,-0.027119216,0.008508213,-0.08253487,0.13726015,0.060484696,-0.08215704,0.014098155,-0.04652902,0.049949046,-0.02665442,0.043253914,0.15520732,0.008389916,0.033077095,-0.10881565,5.1551022e-33,0.020568317,0.0368259,0.04485873,-0.0051650875,0.026930403,0.024764216,-0.070039034,0.08247629,0.015202882,-0.08331969,-0.09424214,-0.061313897,0.06316547,-0.026264757,-0.05619905,-0.053424753,-0.009642325,-0.058770686,0.01989658,-0.02916983,0.08536364,0.013621613,-0.053696625,0.08251233,0.04596015,0.009334365,0.055800706,-0.0495297,0.058359664,-0.040858284,-0.023885675,-0.06923085,-0.036634576,0.0020348039,0.024464235,-0.030174745,-0.009862852,-0.0064899977,0.052294303,0.12296204,0.047395624,0.040106125,0.03294771,0.00898926,0.060297538,0.0064714067,-0.020581406,0.10448634,0.04946242,0.059530396,0.024285069,-0.06491839,0.08985539,0.043677744,0.010694788,0.04450898,-0.056187324,0.008297508,0.0070890402,0.006472472,0.019438582,0.024422774,-0.016834037,-0.012064598,-0.0113232285,0.046340648,-0.15911219,0.01828488,0.01886858,0.08791782,-0.047373883,-0.019287992,0.04550891,0.056500256,0.027270049,-0.03393425,-0.11891482,0.053510092,-0.046589866,0.021801425,0.0023901279,0.071872234,-0.044144392,-0.0236086,-0.027567353,-0.048887808,-0.058718316,-0.022435049,-0.0054152682,0.022303171,0.08207534,-0.0135809155,-0.044015642,0.01540126,-0.021406092,-4.7569854e-33,0.059760123,-0.07496152,0.039859995,-0.0125542665,0.0055122552,-0.004348345,-0.009864041,0.008477534,0.087926365,0.010785211,-0.007913418,0.04233806,0.103399724,-0.041722916,0.006632505,-0.052510362,0.016767276,0.06184643,-0.032800894,-0.030070046,-0.07857899,0.043815833,-0.020192308,-0.0076523283,0.064545125,0.040544078,0.009820233,0.082628295,0.019849323,0.041090526,0.0068624523,-0.049745906,-0.0521104,0.013377456,-0.01713291,0.025613355,0.031123063,0.0021182124,-0.043530505,0.009479283,-0.029911868,0.018439464,-0.01628754,0.11186779,0.026774386,0.044524536,-0.025476305,0.04333237,-0.046298534,-0.06617137,0.04930964,-0.05082043,-0.0107837375,0.013010835,0.0265053,-0.009451775,0.035793424,-0.032055043,-0.06506096,0.007715105,0.036404192,-0.078065366,0.02631492,-0.028871734,0.011594938,0.03972924,-0.055510905,0.10703537,-0.01101328,0.043095976,0.050705213,-0.03980494,-0.01882733,0.03965589,0.004712943,0.025120301,-0.044935845,-0.034767333,-0.0098223,-0.08657933,-0.06192306,-0.029512338,-0.036195166,-0.024621211,-0.047822405,0.05325373,0.0021344856,0.14428191,0.0069180117,0.044973217,-0.1103391,0.0037954464,0.005593765,0.16372177,0.035054687,-3.894494e-08,0.003057492,-0.02403455,0.03183878,-0.005033873,-0.005455174,0.042118534,0.0054417583,0.0048111416,0.066514365,-0.05641097,-0.08547913,0.03892295,0.0050065685,-0.0021368817,0.017715266,0.016935963,0.07249094,0.05945696,-0.007600876,0.004871581,-0.053605862,0.016133549,-0.14114788,0.010457067,-0.030398916,-0.0736926,0.01805817,0.07842624,0.024051135,-0.050741754,0.011424708,-0.022280134,0.05286304,-0.049183205,-0.059660908,-0.0063730096,0.009774264,-0.06190883,0.07029191,-0.05255139,0.048554163,0.00050262664,-0.07047889,0.0021057422,-0.012636046,-0.03335531,0.040541366,-0.01644454,-0.003521068,-0.0018678867,-0.001904122,0.024200331,-0.046323963,-0.049475864,-0.027748862,-0.04045495,-0.047162183,-0.05278759,0.036606114,-0.008996775,-0.053331394,-0.014293755,0.18999727,0.06901665 +2.1.3.6,"The plant enzyme also catalyses the reactions of EC 2.1.3.3 ornithine carbamoyltransferase, EC 2.7.2.2 carbamate kinase and EC 3.5.3.12 agmatine deiminase, thus acting as putrescine synthase, converting agmatine [(4-aminobutyl)guanidine] and ornithine into putrescine and citrulline, respectively.",384,1.0,-0.10863454,-0.012215787,-0.05800305,-0.030618249,0.04975653,0.1142801,-0.09555473,0.06818885,0.05160508,0.018356116,0.06817208,-0.072605506,-0.026717668,-0.06875774,-0.0523027,0.05186228,-0.08944753,0.06673997,-0.024648786,-0.05533342,0.022011127,0.045191254,-0.038389586,-0.020269044,0.061503753,0.021220978,-0.01740338,-0.008485912,0.0019813823,-0.0598184,-0.0339826,-0.08178447,0.03186842,-0.02173216,0.034785498,0.005828614,-0.053717688,-0.061166625,0.026460288,-0.016703378,0.05613903,0.017247315,-0.046488702,-0.059645563,-0.010715964,-0.026741862,0.04139757,-0.015878724,0.025569819,-0.074973494,-0.01634473,-0.027143786,-0.030618805,-0.049470466,-0.0077582397,-0.035608735,-0.03944036,0.016743362,-0.014839365,0.080731675,0.05386984,-0.044651315,0.009640872,-0.0466941,0.041696873,-0.012880116,-0.017521182,-0.04879053,0.0037055328,-0.018997204,-0.051283274,-0.083166085,0.011680259,0.08270299,-0.023628643,0.031087063,-0.081960045,0.060381673,0.05507115,-0.010069637,-0.00907202,-0.022370854,-0.055760108,0.030193163,-0.03049813,0.013235295,0.024547484,0.12870555,0.0636327,0.0077173896,0.023878194,-0.029464964,-0.027255395,-0.009444491,-0.04515075,0.10239039,-0.013445362,0.025400385,0.05385967,-0.056701753,0.027452005,0.07878486,-0.07334544,-0.08431844,-0.075225554,0.040276024,0.013028865,0.043921057,-0.0046800342,0.014800984,-0.02166857,-0.03558842,-0.022167636,0.009781577,-0.0927453,0.1399902,0.058877055,-0.07347765,0.020559369,-0.03729804,0.042776484,-0.03479125,0.033985082,0.1616338,0.0045953807,0.035736755,-0.11165816,5.451113e-33,0.028209563,0.04114113,0.04168685,-0.0037471363,0.02523026,0.034265406,-0.06264143,0.08154661,0.016380219,-0.10186964,-0.08507924,-0.074563295,0.061263494,-0.027217237,-0.054522213,-0.062099844,-0.016272316,-0.05850894,0.014645393,-0.03082529,0.08114557,0.0015247538,-0.06948951,0.089061506,0.05119958,0.012875659,0.0566537,-0.04983156,0.052968476,-0.044126116,-0.017180035,-0.07180204,-0.04118567,0.00056438503,0.023952961,-0.03350622,-0.0017656133,-0.001201654,0.04681669,0.12529641,0.03487253,0.03764829,0.033866078,0.0050700414,0.05808668,0.013906082,-0.024017505,0.11005465,0.038961686,0.06078163,0.025507828,-0.06172438,0.08126765,0.045255903,0.009227652,0.050971564,-0.052324425,-0.0059830663,0.009784989,-0.0022427395,0.029359186,0.027707744,-0.0111082,-0.012750104,-0.016928738,0.044300642,-0.1499694,0.013269667,0.023379358,0.089520305,-0.05290024,-0.013571972,0.043851618,0.061444703,0.020739002,-0.026368674,-0.123941906,0.056958593,-0.039846674,0.016609991,0.0012385019,0.05968904,-0.034641664,-0.028726265,-0.023403319,-0.05152675,-0.059073027,-0.030958764,-0.0011974224,0.02830446,0.07693852,-0.014618278,-0.045968458,0.009674521,-0.027024472,-4.906839e-33,0.061499584,-0.07179808,0.040509578,-0.012641808,-0.00014901838,-0.0037553392,-0.016721115,0.016334116,0.091437995,0.021401959,-0.0037267131,0.043376528,0.1127365,-0.045252062,0.015351164,-0.05318417,0.020065082,0.07473421,-0.02886731,-0.026226249,-0.07322378,0.048402227,-0.02287686,-0.0027499017,0.06256421,0.040981244,0.0054412386,0.09237305,0.021012517,0.050297953,0.0051279454,-0.046751,-0.04988006,0.012147657,-0.008902203,0.028481828,0.03337746,0.00022713868,-0.03833986,0.008868971,-0.039428044,0.017709246,-0.0065065403,0.10224335,0.016306637,0.04292972,-0.019405998,0.04007182,-0.04741527,-0.065287285,0.04568051,-0.043206893,-0.004215083,0.011427776,0.024568357,-0.002410484,0.04030192,-0.034860447,-0.06473796,0.007975232,0.04253965,-0.07139623,0.035029907,-0.026449382,-0.0028249957,0.05060434,-0.057394587,0.10532917,-0.0092874495,0.038024344,0.02999879,-0.051192645,-0.016992064,0.041963905,-0.006660792,0.02920378,-0.04599401,-0.03406842,-0.009661352,-0.09090241,-0.061301515,-0.023466552,-0.038162287,-0.035691366,-0.04837212,0.05845708,0.00056929066,0.1477699,0.0060618627,0.045140877,-0.09991944,0.0017621403,-0.0012094371,0.16532966,0.03853079,-3.962584e-08,0.000109197186,-0.024865765,0.036981676,-0.0003244474,-0.00020546962,0.031306613,0.008850703,-0.00082115055,0.06720129,-0.060788028,-0.07958972,0.039882384,0.0013486682,0.0006901859,0.020631004,0.012855966,0.076568946,0.05965731,-0.0068686088,0.004581202,-0.05085348,0.014880896,-0.13531552,0.010786554,-0.030129507,-0.06643365,0.018988756,0.07960424,0.033354536,-0.056771606,0.009424231,-0.015611539,0.04340183,-0.04925358,-0.067577265,-0.0045865914,0.004186279,-0.06463835,0.07297121,-0.05920628,0.042806745,0.001341718,-0.06339034,-0.0008924725,-0.01755421,-0.0359284,0.042248905,-0.02398465,-0.002356963,-0.0038007724,0.0029732054,0.013859876,-0.04092645,-0.050508883,-0.030893745,-0.03389667,-0.051078986,-0.047671575,0.030164901,-0.01215457,-0.050373808,-0.020293344,0.20061025,0.06883779 +2.1.3.7,Acts on a wide range of 3-hydroxymethylcephems (a subclass of the cephalosporin antibiotics). Activated by ATP.,384,1.0,0.0006860877,-0.04928637,0.00036115551,-0.0774193,-0.017683214,0.031863682,0.01573224,0.022774544,0.11709874,0.018674577,0.019824864,-0.12109138,0.013912603,0.09750642,-0.013931973,-0.023567144,-0.08461562,0.005512771,-0.02746172,0.007973153,0.06717131,0.0007548816,0.04282849,0.01802349,-0.00519487,0.05889549,0.034026332,0.028729912,0.010416953,-0.044972654,0.01852924,0.035407584,-0.015590524,-0.0039991857,-0.008678522,0.08202642,-0.027360594,-0.019815676,0.087833576,0.015894381,0.083794355,-0.062573306,-0.02079509,0.031853087,-0.044807285,0.039519254,-0.018056035,0.06447472,0.046957422,-0.018338116,0.010753403,-0.045092896,-0.044556092,0.13439913,0.002307629,0.009871737,-0.028599035,0.020457758,-0.027601242,-0.03540347,0.0141738,-0.032179058,0.047338437,0.07290293,-0.03735423,-0.03553062,-0.029012732,-0.07577632,0.04611038,-0.03815046,-0.09079423,-0.08822615,0.08781066,0.065225676,0.0030514721,-0.009423907,0.016037721,-0.08033666,-0.06743665,-0.08140437,0.038659744,-0.0070844134,0.031766985,0.091232285,0.085835695,-0.09686304,0.04495772,-0.027936187,0.021036811,0.09590083,-0.009608707,-0.011349269,0.0012235371,-0.014718242,-0.0638641,0.03357522,0.024704274,-0.038054816,0.026783576,0.030292742,0.0131454,0.07496312,-0.03145195,-0.054275107,0.006120561,0.025348281,-0.0326332,-0.003134004,-0.022246031,-0.0017176134,-0.026968494,-0.08362775,-0.024764178,-0.050054964,-0.066537835,0.10955359,0.043075487,-0.050094433,-0.029867014,-0.06098358,-0.026123041,-0.090209566,-0.011811074,-0.018202443,-0.09797507,0.06096625,-0.070418246,-1.4554976e-33,0.028670602,-0.028026158,-0.015636018,0.019039154,0.033429816,-0.03392396,-0.020410439,0.0035837549,-0.016215252,-0.09473987,-0.02045056,0.007948123,0.03236954,0.05091079,-0.013804945,-0.06599153,-0.06252247,0.051919628,0.04421078,-0.07502482,0.05225271,0.037505038,-0.010724408,-0.06849243,0.00056608766,0.035629038,-0.08794752,0.06860314,0.10066491,-0.0097876275,0.0058449265,-0.013638051,-0.07850448,-0.0048300596,0.008336414,0.06696755,-0.08635967,-0.061843436,0.058456942,0.026568897,-0.03542288,-0.022296451,0.0348589,-0.07265817,0.03146257,-0.012703262,-0.11571791,0.027567502,0.056730535,0.06800105,0.14086492,-0.15745558,0.07247832,-0.026910271,-0.0017701627,0.025152637,-0.059199136,-0.020571433,-0.003355502,-0.022103079,0.021130083,0.039632615,-0.058555108,-0.013445955,0.09950041,0.017337803,-0.049941383,-0.006247403,-0.0704242,0.012699786,-0.08229974,0.036600318,0.029585168,0.04507373,0.055945475,0.061396804,0.031527847,-0.020409454,-0.02377499,0.088007204,0.062399182,-0.008530837,0.020115396,-0.023394449,-0.061704937,0.02021179,-0.003016272,-0.054301396,-0.02434085,-0.02166007,0.08608461,-0.049341157,-0.052419625,0.045164067,-0.04738486,-1.3611076e-33,0.08376676,-0.027538883,-0.0012792876,-0.029590469,-0.006478655,0.06815993,-0.0356763,-0.032628484,-0.009223922,0.044172365,0.049459677,-0.047985956,-0.052528705,-0.058375485,-0.037121456,-0.089407004,0.06189844,-0.013189517,-0.05852656,0.030196277,0.026692249,0.070712335,0.020639205,0.088055946,0.03510569,-0.014468152,0.05794328,0.040428296,-0.003453186,0.078025155,-0.055097356,-0.03021632,-0.042791944,-0.024507789,0.007860246,0.04835003,-0.048172567,0.025528831,0.004334366,-0.042242475,0.057321757,-0.025870504,0.028583754,0.071231045,0.07960854,0.080904886,-0.009436095,0.031160899,-0.02919015,-0.0063188677,-0.015700987,-0.035798676,0.008468084,0.017081529,0.052164182,0.03630618,-0.015554485,-0.03377537,0.09059799,-0.098946996,-0.031481553,0.0073962696,0.034013055,-0.012726457,-0.01906023,0.054557372,-0.10284843,-0.006181027,0.041524045,-0.0026685214,0.075013734,-0.00025479076,-0.03698306,-0.09053776,-0.027436687,-0.017307855,-0.033841047,-0.09967598,-0.039731592,-0.04251245,0.034461826,0.062816285,0.0028119644,-0.05992332,0.0067701233,-0.022428937,-0.01110383,0.037972867,0.0014695055,-0.010256744,0.043239426,0.06010234,-0.017658535,0.0016804504,0.03861209,-3.0247325e-08,0.025666397,0.025706625,0.084572226,0.002557912,0.008118739,0.02202999,0.008505838,-0.00049727526,0.09072768,-0.053808663,0.024918461,0.044849396,0.077864185,-0.032767877,0.071278475,-0.002585345,-0.090188846,0.03335138,-0.026530921,-0.048372746,-0.08019742,-0.047570165,-0.06123717,0.107326284,0.10347926,-0.008891868,0.033202883,0.04381725,-0.058169737,-0.030655911,0.051140636,0.035026386,-0.05485371,0.01788554,-0.03492048,0.00047754683,-0.0676322,-0.023451123,-0.059357207,-0.00782831,-0.0034627563,-0.0027355826,-0.0658565,0.020837499,-0.013808555,0.08857766,-0.022513663,0.042666726,-0.03228261,-0.050332837,0.0527439,-0.032417413,-0.0048356554,0.022480424,-0.15191674,-0.0129186185,-0.025128512,-0.061515506,-0.06451072,-0.08344116,-0.015099339,-0.0029770962,0.16784607,0.06231099 +2.1.3.8,Not identical with EC 2.1.3.3 ornithine carbamoyltransferase.,384,1.0,-0.12260204,-0.008200109,-0.030624801,-0.030116558,-0.020903789,-0.04431053,-0.107190475,0.064114176,0.06935567,-0.095694065,0.076789334,-0.10112573,-0.023554511,-0.002437702,-0.011774772,-0.015885364,-0.051914208,-0.01757002,0.02515178,0.047988743,0.011546039,0.041351832,0.057211425,0.041242152,0.07683117,0.0154457195,0.025031136,0.08271611,0.036350176,-0.0904521,0.031668197,-0.034591615,-0.032478046,-0.08054065,0.09267925,-0.028691202,-0.022291021,-0.06596739,0.01484612,-0.0026803964,0.08619965,-0.00095973635,-0.072806746,-0.0017113651,0.022882452,-0.035970017,-0.043200478,0.056482,-0.006631635,-0.070403405,-0.00925872,-0.074879594,-0.027062355,-0.007324484,0.030445823,-0.00020110556,-0.08529401,-0.0011737649,-0.019524995,0.0783445,0.007822836,0.010264204,0.034092907,-0.000951555,0.050672483,0.019645132,0.05534778,-0.16907832,0.009680887,0.0077676964,-0.09072374,-0.030543324,0.025277423,0.11374165,-0.0034662234,0.020463834,-0.004694057,0.06986547,-0.0012150422,-0.07648094,-0.0035924488,-0.08696876,-0.04493418,0.032404512,-0.029288772,-0.09814898,0.017395038,0.043212708,-0.03091252,0.045160826,0.035877112,0.005592056,0.09298392,-0.0023874224,-0.037581906,0.038455393,0.044359222,0.122845404,0.09715783,-0.03890362,-0.0022425575,0.093587056,-0.06842002,-0.048405245,-0.042293206,0.067330524,0.037267067,0.02343561,0.03063442,-0.039046973,0.01842269,-0.05583252,0.0424677,-0.008769452,-0.13623296,0.04819655,-0.03937843,0.006449786,0.07103285,0.08314536,0.031228554,-0.0969922,0.029798286,0.055859447,-0.047970265,0.07145291,-0.054314658,3.0762766e-33,0.022453392,0.052586034,0.07024812,0.010130096,-0.026020365,0.05544663,-0.12263574,0.035119414,-0.056625426,-0.11306386,-0.084353365,-0.07699038,0.016284497,0.010921208,-0.034806732,-0.049039792,-0.08752528,-0.022382399,-0.034543216,0.0025919573,0.05633701,-0.012553118,-0.050816935,0.032274093,0.07639895,0.044874854,0.02097551,-0.031381395,0.014544631,-0.01196844,0.019978544,-0.10072883,-0.043340396,-0.049878284,-0.016628193,0.0016440817,0.077718854,-0.054580126,-0.021259068,0.049508873,0.025685834,0.05760758,0.0052733948,-0.0830084,0.06034659,-0.011149798,-0.008799351,0.060811292,0.04228911,0.048265103,-0.008412694,-0.038621627,0.019554276,0.00070115016,0.018785307,0.0030245106,-0.015901929,0.026397048,0.038717296,0.012945996,0.06962123,0.13011111,0.008243054,-0.03232442,-0.046805862,0.04852453,-0.0829219,-0.018718295,-0.039680414,0.024153395,-0.01473347,0.03146712,0.10238333,0.015437649,0.056072474,-0.046662673,-0.116634846,0.03746654,0.020171741,-0.01413528,-0.077132486,0.0033616603,0.06923156,-0.0727432,-0.03708325,-0.02016345,-0.023275869,-0.025848264,-0.0061789216,0.08856321,0.05710871,0.013700127,-0.059543278,0.0021799472,-0.013991003,-2.9734578e-33,0.015608736,-0.01762779,0.02546825,-0.012736047,-0.008844654,0.030780945,-0.0050375084,0.06964827,0.08002418,0.024073886,0.13446513,0.005280794,0.071645066,-0.118536256,0.12324191,-0.021046234,-0.019331995,0.043853894,-0.01909329,0.04307645,0.03347069,0.0010072644,-0.05336283,0.069745794,0.021301268,0.074640736,-0.03212785,0.07592236,0.06834596,0.017558228,-0.0053345584,0.032582346,-0.06560958,-0.03379319,-0.039589778,-0.003917488,0.011547426,-0.042829465,0.0014990623,-0.027855901,-0.074026115,0.039310005,-0.030518616,0.005030411,0.014106887,0.076967075,0.071415044,-0.036251657,0.03579276,-0.02732944,-0.0064592347,0.0033086636,-0.0316116,0.0546576,0.011131064,0.03635122,0.04211781,-0.0038621644,-0.058536537,-0.009222959,0.018803142,-0.009996417,0.06928054,-0.024852622,0.00058378815,0.078957275,-0.036408275,0.07703695,0.06880456,-0.028136859,-0.03205604,-0.0899412,-0.057255037,-0.015443367,-0.032622438,0.05001974,-0.04064633,-0.014372825,0.012960323,-0.07334556,-0.007120208,-0.0163146,-0.017944105,-0.031821113,0.000572079,0.04667975,-0.014494561,0.04241904,-0.033238992,0.071150936,-0.031356003,0.005937398,-0.09139249,0.084969096,0.03609085,-2.4542683e-08,0.074883156,-0.08005942,0.047282405,0.006792198,0.039324827,-0.019885717,-0.066756405,0.02127776,0.010822051,-0.022514768,0.011959645,-0.006893918,-0.005329446,0.0127510335,0.031196548,-0.0020329806,0.008059509,0.017275168,-0.017258028,0.009533101,-0.0884021,0.026362482,-0.020260341,-0.024438145,-0.016495213,-0.026007771,-0.0027229225,0.06344835,0.037165444,-0.120010614,0.029004082,0.020043487,0.001012087,-0.020651575,-0.06559472,-0.011244955,-0.020745974,0.021045988,-0.0035828976,0.052749693,0.016642895,-0.063182995,-0.08083995,0.026047142,0.07316212,-0.012216465,0.016920593,-0.022981057,-0.034902636,-0.09259347,0.012082194,-0.03271112,-0.036146924,-0.040471423,-0.03703552,0.02645999,-0.08532784,0.0067371707,0.033693757,-0.017636588,0.02383721,-0.07267337,0.13342395,0.055498462 +2.1.3.9,"Differs from EC 2.1.3.3, ornithine carbamoyltransferase. This enzyme replaces EC 2.1.3.3 in the canonic arginine biosynthetic pathway of several Eubacteria and has no catalytic activity with L-ornithine as substrate.",384,0.99999994,-0.09549954,-0.028323423,-0.035684627,-0.026388356,0.043186788,0.020991527,-0.07300682,0.0551424,0.03837437,-0.020838141,0.00832095,-0.06412491,-0.028506894,0.015185613,0.025455208,0.029503321,-0.12631452,-0.018005399,0.03990891,0.001325051,0.06053782,0.064516395,0.03529772,-0.0104330275,0.042575702,-0.013924581,-0.0060384595,0.04371132,-0.0028575603,-0.101013795,-0.0013706262,-0.06539585,-0.01840611,-0.10409619,0.08315847,-0.03646396,-0.00043184546,-0.08120598,0.021293195,0.032659445,0.07026411,-0.006316158,-0.14801575,-0.037149247,0.025848843,-0.0030005472,-0.0032594155,0.009180546,-0.027042547,-0.03453847,-0.0066922144,-0.026536949,0.008810593,-0.012951712,-0.012510713,0.02565904,-0.0953875,0.007841152,0.016885474,0.04368794,0.0389861,0.029510587,0.017721487,0.013819433,0.01995762,-0.03174372,0.05501679,-0.14909872,0.04820232,0.0015188892,-0.083245784,-0.093678504,-0.027453914,0.09733597,0.009162754,0.030666623,0.030964842,0.030423677,0.001032682,-0.053855635,0.012830997,-0.07132541,-0.059791528,0.080264024,-0.035263814,-0.09704785,0.006545203,0.034708336,0.020985655,0.030429933,0.04373584,-0.05224122,0.06143781,-0.0068238988,-0.00054054975,0.014223824,0.044218373,0.08648545,0.0821184,-0.020492569,-0.02050632,0.08067513,-0.09669446,-0.050696313,-0.0012812219,0.034121677,0.042893514,0.016563673,0.044932187,-0.06714044,0.03437773,-0.06180096,0.018054044,-0.05860315,-0.10208671,0.064144,0.027891574,-0.075142264,0.021872692,0.04118254,0.030866321,-0.099094346,0.055640195,0.07938151,-0.04558323,0.115959875,-0.06599804,4.3298453e-33,0.03794428,0.063990384,0.04682692,-0.03984869,-0.006216688,0.08260263,-0.09042443,0.038874973,-0.013827565,-0.15816264,-0.056719992,-0.036378313,0.045291215,0.0640954,-0.03824356,-0.012236877,-0.048302475,-0.013004031,-0.014197092,0.008939291,0.03525553,-0.02159728,-0.0547867,0.08970585,0.085396156,0.0126303,0.076024815,-0.029207395,0.0078112814,-0.01018987,-0.008173186,-0.11399113,-0.024192654,-0.049822178,-0.00034668882,-0.03187356,0.03533921,-0.021541297,0.017827427,0.05748334,-0.03652784,0.07700366,0.011230903,-0.042305492,0.04884621,0.0015144343,-0.041816864,0.08448126,0.0060973098,0.04981711,0.035183463,-0.0146645075,0.025220195,-0.029077096,0.020455789,0.013015445,-0.013406273,0.024426531,0.06194897,-0.028867718,0.09668807,0.07663239,0.076869406,0.037226226,-0.0051144366,0.086187966,-0.064069405,-0.00537332,-0.014410769,0.057577334,-0.11915576,0.04825938,0.093114465,0.01466206,0.061984066,-0.003025596,-0.14071658,0.0030513753,0.010978357,-0.010273916,-0.07843638,-0.011322217,0.03808805,-0.01965047,0.01765772,-0.07008584,-0.060814332,-0.008857314,0.055516526,0.027544867,0.07068932,0.014095175,-0.0641524,0.02336284,-0.0394258,-4.1942414e-33,0.049921785,-0.050208095,0.007379644,-0.011546629,-0.03427149,0.0110456385,-0.008921825,0.05867508,0.10134972,0.022226837,0.106484465,0.005314479,0.08815046,-0.06438604,0.1222756,-0.04534405,-0.03337591,0.051180087,-0.018546691,0.05413826,0.04077173,-0.030876303,-0.065546244,0.05648503,0.028276842,0.042431775,-0.06432539,0.0305389,0.030569168,-0.032375384,-0.017296419,0.0048209517,-0.02532511,-0.042989362,-0.009314223,0.026856484,0.043484412,0.002112675,0.002193932,-0.03714576,0.0019685773,-0.008642607,0.015121737,0.0012867227,-0.01718871,0.047260515,0.02959143,-0.026606925,-0.00048682198,-0.07415988,0.0060295667,-0.018728673,0.017809806,0.011322794,-0.008682165,0.0050361794,0.021991456,-0.018870536,-0.040361818,0.024695259,0.04680972,-0.037435327,0.10382982,0.0031477606,-0.025858808,0.062233757,-0.05644421,0.09300914,0.0031802738,-0.059368446,0.02729361,-0.058059037,-0.004222043,0.04813456,-0.013195861,0.052740972,-0.035378873,-0.069376625,0.026449319,-0.050892,-0.005407197,-0.038834542,-0.04716947,-0.024552017,-0.030468242,0.071690924,-0.025840694,0.05817054,-0.051271327,0.02504321,-0.024939088,-0.032084063,-0.060250573,0.07356067,0.051830567,-3.412705e-08,0.08109993,-0.032461893,0.053120352,0.041828923,0.011705845,-0.01745029,-0.045244087,0.051902417,0.03582658,-0.043145105,0.05792275,0.010752626,0.02445747,-0.023462612,0.0786098,0.026848001,0.034163926,-0.0025634447,-0.016554791,0.034582473,-0.07840021,0.01643814,-0.061397873,-0.040781304,0.010915895,-0.07317999,0.017298354,0.055346347,0.019430855,-0.147773,-0.00056335353,0.038120702,-0.052322455,0.044357162,-0.07813976,-0.016664084,-0.046769608,-0.037570853,-0.008706391,0.023911849,-0.0018648581,-0.02352951,-0.09243868,-0.0009067927,0.022701433,0.0040911767,0.04097141,-0.02910267,-0.04459966,-0.088410534,-0.012365363,-0.079554126,0.033549238,-0.043478686,-0.040434062,0.040896226,-0.0848355,-0.04709117,0.0017369408,-0.021620454,0.038346563,-0.02070439,0.17915703,0.028326944 +2.1.4.1,Canavanine can act instead of arginine.,384,1.0,0.03322926,-0.079383016,-0.11826554,-0.047156807,-0.062738866,0.017510276,0.08786898,0.03571013,0.009738096,0.050430216,-0.02515408,0.09348768,-0.0015690614,0.10980123,0.0075400732,0.01378943,0.07976769,-0.034579445,0.05439452,0.047864605,0.020182986,0.069293,0.0038156125,-0.072930306,-0.02933317,0.037626207,-0.044371754,-0.021172594,0.026404403,-0.11572464,0.039608933,0.022177693,-0.047768265,-0.050979644,-0.065557815,-0.036283523,-0.10629155,0.037354268,0.017224308,0.0061252546,0.005191725,0.022137236,-0.12062502,0.016674194,0.011045498,-0.05224271,-0.010712558,0.037009947,0.040621042,0.08231928,-0.028459052,-0.04000257,0.02290828,-0.031472757,0.015744267,-0.0009230353,-0.16055612,0.02921198,0.0024880061,0.08118179,-0.03667821,0.04586739,0.023468908,-0.027974064,0.028567266,-0.029579502,0.04010767,0.023215748,0.08549033,-0.0013511276,0.023991821,-0.051158406,-0.014438187,0.01579469,-0.029390806,-0.03472997,0.034988042,0.012473007,0.0024301368,0.048963513,-0.012765287,0.007487136,-0.0066319206,0.051926903,0.03288039,-0.03283139,-0.043214593,0.026515981,0.015133492,0.036950376,0.044124156,-0.04589009,0.050554994,0.024047798,0.025851151,-0.065730415,-0.052394558,-0.018400546,-0.08368274,-0.00042073417,-0.020824641,-0.018361006,-0.08145997,-0.047173325,-0.0029548646,0.010450267,0.062300637,-0.116697,-0.0022534507,0.046909057,-0.08417073,-0.04526752,0.026717205,0.018553242,-0.06188194,-0.0055168434,0.06034548,0.002466047,-0.087008074,-0.02793071,-0.046120644,-0.009702137,0.034185104,0.020540174,-0.017337598,0.048329752,0.0009793153,-2.584147e-34,-0.00023918599,-0.006470385,0.04010714,6.984518e-06,0.06105436,0.03968947,0.012403749,0.03085205,0.09062511,-0.09687836,0.0062126326,-0.053138796,0.011502826,0.046282176,-0.004159692,0.024123402,-0.013306387,0.0008913796,0.013270458,-0.003932124,-0.072014034,0.09907707,-0.08024446,0.007863993,-0.11285931,0.026186379,0.06842117,0.07648363,0.028365824,-0.008153022,0.008908105,-0.045090135,-0.05289943,0.06289084,-0.0136761805,0.0013722283,0.06187149,0.010886998,0.0025524818,-0.0009802604,-0.056842066,0.0753677,-0.04627135,0.014019394,-0.0030832302,-0.044689167,-0.06794323,0.037564605,-0.083003424,0.025923694,0.02034399,0.013755656,0.07110194,-0.012283396,-0.00955281,0.07328908,0.024213959,0.036092516,0.10253384,0.039992128,-0.040138233,-0.046034954,0.06916803,-0.0012926493,-0.053192485,0.03887832,-0.07254709,-0.07163588,-0.040835556,0.008201394,-0.039132364,0.0427372,0.0073694293,0.008452117,-0.0044461815,-0.06475254,-0.029836906,0.028775016,0.044001006,-0.06863251,-0.014115811,-0.06351895,0.094304256,0.077644125,0.0011984338,-0.031181023,0.056709774,-0.070654295,-0.018360356,-0.010315537,0.016543284,-0.005905034,-0.017428903,-0.0021842837,0.055659562,-3.7264305e-34,0.04273882,-0.05994005,-0.011546628,0.025755305,0.0563699,0.051424995,0.038134336,0.027706059,-0.00015515219,-0.011214786,-0.004451333,-0.05654055,-0.016437635,0.00369543,0.00698901,0.008170837,0.028917793,0.038970467,-0.073056236,-0.009470325,-0.116284095,0.0049445904,-0.058572806,0.05917002,-0.034845658,0.049776766,0.004928665,-0.040440243,-0.0163908,0.046648964,0.023251625,-0.029161338,-0.10400499,-0.02479234,0.06792218,0.065100454,0.087072134,-0.022029394,-0.16387361,-0.11575331,-0.017728226,0.03405167,0.015092662,0.044671293,0.02292676,0.04337081,0.048482515,-0.06500133,-0.03792971,-0.016517231,0.07108992,-0.038493875,0.019852687,0.013895658,0.022259662,-0.056210548,0.09312431,-0.086669125,-0.03983887,0.007767792,0.060369864,-0.02915661,-0.05409823,-0.07413719,0.097826295,0.009316363,-0.049409315,0.04514417,0.025968408,-0.051593505,0.06005207,-0.1027458,0.031317346,0.055629484,-0.012223231,0.039405756,0.08081983,-0.09645765,0.018825911,-0.12222996,-0.017927533,-0.041791286,-0.059681926,0.0117787765,-0.045459855,0.07184634,0.04653434,-0.011897893,-0.027729778,0.09184605,-0.0118727535,0.01573244,-0.05531743,0.04507269,0.102000594,-1.7295921e-08,0.007257672,-0.041589174,-0.0037954478,0.04290537,-0.06298222,0.051170327,-0.029626999,-0.021493008,0.042153586,0.007320359,0.044850416,0.06458969,0.05102095,0.09931416,0.021786552,0.03080727,0.029228382,-0.0048952247,-0.004259869,0.074692525,-0.17165788,0.059996147,0.009956727,-0.087558195,-0.023747494,-0.07920621,0.01462288,0.08081409,0.04999298,-0.023750573,-0.034685727,-0.010107674,-0.022789882,0.01540876,-0.07987321,-0.032807447,0.121429406,-0.0004168434,0.021313794,0.00027565044,-0.059725527,0.023245845,-0.04282381,0.026746633,-0.0011823932,-0.045616522,0.03743407,-0.030930823,-0.015168992,-0.027190994,0.0002090927,0.081536524,0.08671292,-0.08321432,-0.0045535313,0.03765062,-0.09310187,-0.032848198,0.061684817,-0.009553761,0.06147998,-0.034302857,0.060641352,0.0445703 +2.1.4.2,"1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor.",384,0.99999994,-0.09543277,-0.066576704,-0.11817201,-0.07286653,0.0079424465,-0.011457845,0.10302239,0.014881521,0.022382153,0.05667399,0.062404547,0.0058458904,-0.062803514,0.10992912,-0.02940288,0.050422713,0.020280564,0.011335767,0.018380724,0.03301923,0.032049518,0.0023515185,-0.03240703,0.0023756658,0.033218652,0.03508544,0.0056589623,-0.029689003,0.0016866473,-0.090782665,-0.06841683,-0.015555979,-0.014622004,0.04006365,-0.0136417,0.06577081,-0.08738951,0.011751949,-0.065467484,0.023837464,0.027202563,-0.013529264,0.032183297,0.0124367215,-0.047744572,-0.10318185,-0.053119577,0.05769527,0.0665878,-0.027132193,0.006262182,-0.01670525,-0.02263127,0.06611348,0.018196855,0.054617923,-0.101554394,0.047994174,-0.01752855,0.028275847,-0.013815291,-0.0087138545,0.04391398,-0.033726215,0.0848908,-0.03370179,0.03294016,0.006910954,-0.013707235,-0.048763037,0.05371152,-0.049676698,0.046522938,-0.044474933,-0.026520796,0.06865065,-0.027404994,0.07338844,0.028186776,0.0014687969,0.0060442537,-0.004597607,0.013625333,0.07245633,0.05444323,0.060171623,-0.10051016,0.10696554,0.013947963,0.06418675,-0.006419025,0.0008276989,0.044896845,-0.057917792,-0.052272696,-0.0018125862,0.025439136,-0.02327706,0.029493835,0.03349061,0.006258989,0.065759994,4.621148e-05,-0.0594545,-0.035507977,0.02689105,-0.025601685,-0.07400481,0.04479426,0.027507253,-0.08289498,-0.06745214,0.06511477,0.07556703,-0.035848595,-0.008106777,0.0059269317,-0.038078737,-0.011546211,-0.068814225,-0.043233257,-0.024763657,0.01961493,-0.019487176,-0.088680334,0.05932434,-0.03274541,5.5504242e-33,0.023033725,0.01923611,0.0005901284,0.073949166,-0.030511867,0.06985229,0.011988147,-0.0016787245,-0.04992321,-0.07327699,-0.15478928,-0.06516726,0.0733668,0.09858391,-0.037151244,-0.03209598,-0.038911395,-0.0032331191,0.10116834,-0.06810536,-0.009788742,0.11571333,-0.086944826,0.017765427,-0.029165924,0.023190558,-0.058535855,0.03907344,0.064509265,-0.025648436,0.04247289,-0.032031737,-0.08552549,0.01696364,-0.060524188,-0.009944763,0.0043420014,-0.014257481,-0.013438189,-0.01994724,-0.024117816,-0.0034587465,-0.07614525,0.032895535,0.034834884,-0.038783565,-0.01466706,-0.07308646,-0.026694959,0.07546577,-0.053860076,-0.05796569,-0.013339432,-0.09279306,-0.08044046,-0.026165774,0.017480353,0.01815073,0.029360456,0.014916269,-0.037842847,0.0069280495,-0.00644169,-0.042600043,-0.03435998,-0.029250834,-0.06844724,-0.08569459,-0.03311493,0.009923326,-0.04244992,-0.028747335,-0.0050413515,0.04393251,-0.006352454,-0.042936675,-0.002434404,0.012540218,-0.01220172,0.007514043,-0.02203205,-0.086190835,0.00487195,0.11383733,-0.07451086,0.017352574,0.046493802,-0.16851914,0.0021627096,-0.02047625,0.035735387,-0.053732388,-0.054930408,-0.029825564,0.08130773,-5.332447e-33,0.098253936,-0.062764056,0.08049291,-0.039992545,0.030758932,0.09213554,0.02075374,-0.07485393,0.10375145,-0.011796759,0.066681154,-0.030681785,0.07554669,-0.038656704,-0.008103704,-0.0061118593,-0.02004667,0.029059168,-0.020827493,-0.026238969,-0.00664981,0.0507739,-0.027614644,0.036272705,-0.026739998,0.063761994,0.024260767,-0.035541993,0.03350099,0.097865574,0.0023899951,-0.016905507,-0.07335849,0.020762032,0.025647473,0.022968946,0.01308229,-0.0075885877,-0.06324185,-0.026539525,-0.016914636,0.04620317,0.067258,0.10592243,-0.011781569,0.066541396,0.008807729,0.009782921,-0.02374113,-0.023492886,0.0030605863,0.047437843,-0.01014171,0.056757778,0.10710362,0.0037802192,0.077134795,-0.08949496,-0.033035748,-0.034611702,-0.0017692551,-0.046347465,0.016941097,-0.0147009725,0.019511357,-0.0030827967,0.034523547,0.06085036,-0.0058785956,-0.04227861,0.08256282,-0.06948333,0.09790547,0.05624713,0.026851807,-0.07800355,-0.08261964,-0.015274432,0.06471362,-0.12067413,-0.003588224,-0.030825157,-0.030743837,0.02455978,0.09045804,-0.027086252,0.10583145,0.04365327,0.020985652,0.045660958,-0.011667612,0.058760077,-0.024420729,0.09601617,0.09910368,-4.5260457e-08,0.044353697,-0.051878165,-0.020063773,-0.0670532,-0.02513911,0.029613193,-0.024959536,0.055292916,0.040569324,0.0037980943,0.041116692,0.09054826,0.023079207,0.018799337,0.07516002,0.05876762,-0.029402748,0.021814171,-0.011807513,-0.04522093,-0.11598609,0.006030371,-0.032476116,-0.06828703,0.02731104,-0.006279204,-0.00065044104,0.071144,0.06363091,0.019301046,-0.018051958,-0.017315798,-0.0065885233,-0.08167999,0.02918205,0.079655364,0.04271018,-0.037733648,-0.017854659,-0.025088215,-0.010667837,-0.038715713,-0.06596405,0.016156636,-0.010451315,0.012478147,0.01626931,0.057636566,-0.11423037,-0.021812798,-0.00047858083,-0.019878482,0.032602787,-0.046058405,-0.10281304,0.0030630198,-0.02258944,0.026295867,0.07524895,-0.031638145,-0.02158873,0.05561905,0.0907877,0.0077608237 +2.2.1.1,"A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.",384,1.0,-0.033929408,-0.050301168,-0.06695354,-0.009479128,0.019137507,0.03556186,-0.0031767169,0.0333151,-0.010106539,0.047242004,-0.017550573,-0.06624296,-0.05962486,0.078451455,-0.011514925,0.0015100664,-0.019994488,-0.011773675,0.0372671,-0.047128335,0.09489522,0.08403933,-0.021163328,-0.042213112,0.0056543564,-0.007607087,0.118266106,-0.046919513,0.005054906,-0.09253223,-0.07280472,-0.042727344,0.069477186,-0.069213904,0.033178743,0.08076849,0.03197292,-0.0136287045,0.07989805,0.002509288,0.07107381,0.0315343,0.049440123,0.039885614,-0.09447565,-0.0114977965,0.0729358,0.07660093,0.021136686,-0.0017985307,-0.0737534,0.015171187,-0.035487574,0.03538416,0.04920844,0.007083382,-0.005289972,-0.017965011,-0.013072441,-0.066555545,0.016326256,-0.04020891,0.070703335,-0.0353935,0.08424799,-0.10292186,0.040147662,-0.055915266,0.020110182,-0.06718906,-0.12272288,-0.04895061,0.066006765,0.009285882,-0.010641124,0.020902233,-0.05415415,-0.020500222,0.06518118,-0.018868651,0.032210104,-0.01238698,0.0074333,0.041036144,0.032483805,-0.047375113,-0.02374414,-0.015811158,0.039611116,-0.04119893,0.009002866,-0.0581476,0.006407794,-0.022984058,-0.10778333,-0.02707741,0.05423048,-0.046882484,0.025294106,-0.009241412,0.021389036,0.06879362,-0.03055842,-0.10156918,-0.035005223,0.00077279564,0.01422658,0.12973182,0.021679772,0.034936402,0.0037058105,0.061502673,0.033678204,0.036502603,-0.056442406,0.0793027,0.027315175,-0.08351889,-0.09056535,-0.023562506,-0.041409343,0.008219315,0.052907273,0.047170307,-0.044553,0.013361399,-0.11294857,3.0318912e-33,0.07465443,0.041740183,-0.018019844,-0.05959222,-0.0019387665,-0.020551909,-0.067834325,0.00050992804,0.046136,0.0003671811,-0.015421818,-0.056208204,0.13289645,0.03817362,-0.064521894,-0.009047973,-0.018818049,0.03590852,0.09292285,-0.023516534,-0.05674245,0.08506466,-0.064353734,0.025640197,0.04733518,0.040195078,0.052981164,0.074207924,0.026794285,-0.021261256,0.07658151,-0.106177226,-0.08470545,0.009832564,0.090107135,-0.07398331,-0.06310372,-0.019191813,-0.047967855,-0.052177582,0.0027612064,0.0046869493,-0.04710012,0.0019142627,0.0048987027,-0.10013181,-0.0140386205,0.081609175,-0.014351708,0.029798243,0.012923082,-0.038514048,0.11836609,-0.049899977,-0.06368903,-0.046723507,0.018968564,0.009293213,0.096982256,0.03077576,0.013165611,0.013088169,-0.071160495,0.031190364,-0.03093078,0.0061035026,-0.066758096,-0.086432695,0.03185033,0.14046334,-0.028255282,-0.032253735,0.06539937,0.01702014,-0.035044342,-0.0791475,-0.069765285,0.0029442483,0.0063232216,-0.011710022,0.038856015,-0.00813344,0.043640807,-0.03081592,-0.069139965,-0.027601255,-0.009275857,-0.055916525,-0.0043360116,0.028928721,0.08153454,-0.040403444,-0.04011613,0.024334392,0.04648772,-3.5899384e-33,0.07352596,-0.03494251,-0.0051857275,-0.08324643,-0.028005263,-0.02699697,0.064217225,-0.0035534427,0.013126148,-0.04639031,0.097976096,0.00076840527,0.044740796,-0.016017776,0.032845136,0.08801413,0.019992815,0.030855011,0.028145043,-0.03144492,-0.048233952,0.066872194,0.01625918,-0.016944014,0.015506627,0.05959765,0.0034725983,0.038022716,-0.045894526,0.085312426,-0.0009236643,0.023154771,-0.07379068,-0.02000494,-0.11032539,-0.023498395,-0.05318324,-0.03387993,-0.024229566,0.026495365,0.009657575,0.028860245,0.080315985,0.063754104,0.0393576,0.022357492,-0.010050476,-0.02950152,-0.060671143,-0.025731396,0.03361695,0.030077051,0.01794943,-0.036507145,0.026015844,0.061570454,0.009212898,-0.015803922,0.038294606,-0.033427894,-0.063130155,-0.12043363,0.056793854,0.0057975175,0.022890974,0.027230857,-0.05517017,0.012079351,0.078616075,0.03919977,0.04861433,0.059494693,0.06243303,0.019903025,-0.034903366,-0.0060027693,-0.042508006,0.012843764,-0.044565476,-0.0049675466,-0.011258431,-0.00870114,0.0038989023,-0.04749327,-0.025059883,-0.02728208,-0.032579444,0.07359911,-0.022093762,0.09411355,-0.058158375,-0.047501147,-0.071672425,0.03530391,0.14875123,-4.1913573e-08,-0.019951418,-0.04796793,-0.010859977,0.022707269,0.0042584543,0.055390548,-0.034483675,0.024690459,0.08405486,0.0059520425,-0.02162388,0.069280766,0.009049383,0.009798969,0.07439033,0.013838015,-0.05660973,0.01935342,-0.043052197,0.028098313,-0.020153103,-0.052979488,-0.08453395,0.08888199,0.054127567,0.0024105217,-0.0039936737,-0.022841439,-0.05718561,-0.042859197,0.018267341,0.022728836,-0.0077062673,-0.06790457,-0.03305664,0.014555271,0.013744361,-0.026654912,-0.016968606,0.06539171,0.012569999,0.025922729,-0.13809416,0.04160273,0.0026512754,0.03648052,-0.011941178,0.07434623,-0.050985895,-0.07606578,-0.008497176,-0.06573891,-0.03951805,-0.043696348,-0.063272916,0.004873986,-0.053750645,-0.001264608,-0.022868877,0.038177427,0.06597377,0.070258185,0.12399879,-0.09783767 +2.2.1.3,A thiamine-diphosphate protein. Not identical with EC 2.2.1.1 transketolase. Also converts hydroxypyruvate and formaldehyde into glycerone and CO2.,384,1.0,-0.046166748,0.027326258,-0.022645874,0.043807928,0.048279285,-0.025554677,0.004779279,0.061262995,-0.028358366,-0.011662734,0.012333459,-0.08543334,-0.06613495,-0.00541924,-0.002931797,0.0009379253,0.018476557,-0.07618702,0.0431663,-0.07841815,0.054278687,0.1032422,-0.035030976,0.0016448637,0.013013806,-0.020843815,0.043162085,-0.0030836773,0.0055488385,-0.07073484,-0.06457159,-0.05303687,-0.040940445,-0.033768196,0.046325784,0.0858249,-0.011416875,-0.034640662,-0.031372834,-0.002369217,0.10548716,-0.0025491314,0.0070947744,-0.031998638,-0.062161487,-0.0037790409,0.038768157,0.03618891,-0.047779977,0.04914176,-0.053012013,-0.026277566,-0.034134343,0.006914012,0.08239838,-0.004618652,-0.06325428,0.077015914,-0.049599946,0.0048584756,-0.0047238427,-0.062339753,0.0072531975,-0.027456246,0.09307442,-0.1301641,0.07272323,-0.07260589,0.058722004,-0.049512085,-0.125517,-0.06440701,0.07087546,0.022458902,0.01179682,0.01904131,-0.07679126,0.0049359445,0.092855826,-0.03261327,0.031365816,-0.038610805,0.005834301,0.058828205,-0.02689075,-0.03996906,-0.00017515698,-0.0013742261,-0.012577226,-0.003888268,0.02835889,-0.029324282,0.033398088,0.012972816,-0.08778561,0.02232823,0.06508283,0.037550494,0.0240211,-0.018834924,0.005551983,0.1072805,-0.03894624,-0.09899039,-0.067793675,0.026730377,0.01778321,0.089809775,0.06628489,0.024545176,0.006453496,0.018712996,0.080241814,-0.039373554,0.0009053759,0.074694864,-0.00089822523,-0.020780044,0.029448276,-0.049831856,0.03978727,-0.028907616,0.0752313,0.033001434,-0.07700085,0.055329807,-0.10710208,2.8368104e-33,0.10415104,0.08279469,0.006785464,-0.003024674,-0.04574389,-0.023759693,-0.11876867,0.064664364,0.0035426118,-0.05793571,0.025975863,-0.04567096,0.07762459,0.054891057,-0.031205758,-0.07393009,-0.07060618,0.039351646,0.11585914,-0.022603111,-0.023528658,0.06509691,-0.043296374,0.045684095,0.034491148,0.03914793,0.010453252,0.048371024,-0.02065171,0.011735069,0.02544966,-0.08380366,-0.08206569,-0.013587652,0.0412141,-0.05557118,-0.007241352,-0.04668374,-0.017446257,-0.0239291,0.017593328,0.012292551,0.032387994,-0.085697256,-0.012413182,-0.10705532,-0.051657114,0.09138426,0.01981119,0.019778496,0.008835882,-0.040588364,0.14447537,-0.026609555,-0.01941351,0.020325197,0.036549285,0.019938093,0.071905896,0.03924282,0.0070427274,0.09936363,-0.036067545,0.016793832,-0.07023119,0.0125503475,-0.12129708,-0.028176641,-0.0031901177,0.07361119,0.011772205,0.01666596,0.09937862,-0.020962568,0.0053380174,-0.10119387,-0.066673905,0.037182625,-0.06536896,0.05061072,0.004966756,-0.01906421,0.018457416,-0.046969816,-0.059122074,-0.02295436,0.052906405,-0.03932434,0.012696045,0.045991976,-0.0040517612,-0.017475847,-0.026937723,0.015080609,-0.012453636,-2.8217889e-33,0.120503455,-0.06577464,0.010401377,-0.056220908,-0.008734219,-0.037979994,0.06945961,-0.023712233,0.004747296,-0.05233829,0.13402797,0.011352061,0.048136085,-0.06787933,0.054043896,0.015494101,-0.048919298,0.043567214,0.03877552,-0.03327344,0.035427798,0.031426433,-0.051036797,0.04714978,0.02269423,0.016861023,-0.018468041,0.06593881,0.0064654564,0.05580248,-0.041220285,0.0028215288,-0.056908425,-0.013288321,-0.051638212,-0.009132735,-0.05346213,-0.03588455,-0.02230113,-0.026710277,-0.016068902,0.03507886,0.026222313,0.083490245,0.10529454,0.075373285,-0.01585436,-0.041434973,-0.037981655,-0.0022950636,0.039929435,0.030110428,-0.063575,0.016548304,0.0008965128,0.021068003,-0.004070535,0.041841794,0.011695127,-0.013183185,-0.038013436,-0.07364784,0.025841651,-0.009159605,0.037598237,0.05968538,-0.060184054,0.034769528,0.06032677,0.09373679,0.06998575,-0.014833006,0.032021977,-0.006836293,-0.021024806,0.0064128246,-0.014537391,0.046442315,-0.051828876,-0.018073877,0.027339162,0.0023439755,0.036468852,-0.014549056,0.034765672,-0.0077531217,-0.013170051,0.08479102,-0.09802969,0.06184519,-0.09159017,-0.035959475,-0.066785015,0.06439602,0.08521593,-3.5442042e-08,-0.017055565,-0.095090225,0.0305418,-0.0007274761,-0.008544768,0.02585518,-0.010419859,0.04747094,0.051611137,-0.03276195,-0.06183655,0.06994202,0.05795818,0.022794733,0.042588674,0.0032985292,-0.038728133,0.04109032,-0.053206127,-0.010868031,-0.07711323,-0.051371645,-0.07351676,0.059285253,-0.032936655,-0.024741188,0.018807862,-0.0008312404,-0.0061555533,-0.06824812,-0.036044076,0.053358316,-0.0082618985,-0.06866281,-0.040625986,0.025264464,0.008277196,-0.014037687,-0.049630456,0.04156241,-0.008003893,-0.0052952035,-0.10140022,0.027437262,0.0373477,-0.03505874,0.035285912,0.04403686,-0.05931362,-0.038635693,0.033756815,0.015041897,-0.027893243,-0.061798014,-0.04546996,-0.014761031,-0.047258712,0.002466571,0.000519729,-0.008979952,0.08344702,0.073909774,0.20876919,-0.069575265 +2.2.1.4,A thiamine-diphosphate protein.,384,1.0,-0.08089331,-0.008508355,-0.052845582,-0.008935192,-0.0099549685,-0.008899688,0.08867158,0.06044833,-0.010204869,0.030642731,0.026736205,-0.048694246,0.006689777,0.0569292,-0.01152731,0.015394125,0.011099636,-0.041505013,0.020707866,-0.049765196,0.005178324,0.12267674,-0.065429695,-0.021972936,-0.021461753,0.067434385,0.059812415,-0.013213148,0.0037130846,-0.08659743,-0.12188814,0.012667931,0.03196427,-0.04269946,0.03154372,0.06594522,-0.049162738,0.006926556,0.01582329,-0.033747587,0.126263,0.011330333,0.03322762,-0.018699003,-0.0757644,0.004035201,0.07852067,0.081025325,0.05880025,0.06895604,-0.061526455,-0.025555525,0.030837726,0.01387693,0.03475142,-0.044965696,-0.028472142,0.012775305,-0.03833213,0.026187284,-0.015264927,-0.042473573,-0.008844242,-0.04815847,0.17117983,-0.09913953,-0.008820532,-0.017523,0.04000238,-0.050130356,-0.032900088,0.021681247,0.051384714,0.035435114,-0.053553376,0.046780013,0.022324312,-0.030239535,0.069951884,0.012469383,0.008797224,-0.012904543,0.026385494,0.087267354,0.039287515,-0.030835873,0.01601314,0.045591533,-0.039443683,-0.05858424,0.018343266,0.009375835,-0.033803824,-0.0018618377,-0.104120106,0.03737714,0.00797313,-0.038440265,-0.07663245,0.026142927,0.08903679,0.020288698,0.0021568767,-0.058109432,-0.023168389,-0.018907152,-0.0023633735,0.04043457,-0.0017141431,0.040040616,-0.0026129305,0.040709913,0.045801893,-0.008293402,-0.042716052,0.017800042,0.010991428,-0.005722406,-0.04034189,-0.056963768,-0.04982591,0.026854457,0.036847793,0.034382503,-0.04761617,-0.03355186,-0.095208116,-2.2230784e-33,0.07071541,0.0539216,0.043020967,-0.017484106,-0.0184938,-0.011922019,-0.038998317,0.04833572,0.0014333928,-0.028858704,-0.020961048,-0.08400749,0.084453315,-0.009150999,-0.038594477,-0.09061495,-0.033317626,0.007078118,0.10663654,-0.046077006,-0.086670324,0.102290966,-0.06016048,0.022663027,0.01470431,0.0074642515,0.0061687194,0.03498647,-0.012059062,-0.0070122755,0.07563373,-0.05090983,-0.09404059,-0.07193445,0.0735814,-0.09375284,-0.028330285,-0.031441115,-0.069042675,-0.032223415,0.054083128,-0.0051815226,-0.029613292,-0.0144490795,-0.0033177834,-0.108701035,-0.03704339,0.034042478,-0.049540874,-0.006718976,0.02695159,-0.03760962,0.11432143,-0.05953667,-0.07911482,-0.026610846,0.010236068,-0.001361554,0.04803166,0.053076603,0.011230352,-0.0054337056,-0.13221513,0.062162194,-0.07170701,-0.0073548863,-0.12419155,-0.040874053,0.061654046,0.06484494,0.057801176,-0.020916007,0.07116711,-0.032153543,-0.07804834,-0.03471738,-0.045287777,0.05918875,-0.023804752,0.04823427,0.095876224,-0.038004152,-0.007299276,-0.02754372,-0.10930528,-0.032703955,0.09118197,-0.04138834,0.01619424,-0.03557237,0.05025907,-0.027462415,-0.061526995,-0.03263133,0.021615144,4.262859e-34,0.08965645,-0.08797283,0.04366342,-0.03858394,0.0033453282,-0.057531007,0.08571825,0.0088385735,-0.039410986,-0.051010437,0.10090465,-0.013583042,0.040143583,-0.05494334,-0.0004678554,0.12240701,-0.03752116,0.059963718,0.06787214,-0.014212277,-0.06711342,0.039587617,0.059169386,0.047719896,-0.035512965,0.025131794,0.03382383,0.0031276224,-0.039735194,0.100473315,-0.020388402,0.025186416,-0.062149014,-0.028382156,-0.091326736,-0.032251753,0.013432346,-0.087447256,0.0033955716,-0.00887085,-0.038586818,0.05670098,0.07864567,0.088383384,0.06332793,0.06600844,0.013713473,-0.019107353,-0.07996807,-0.018728126,0.04630545,0.010541479,0.007797401,-0.0075894357,0.025498688,-0.04259823,-0.036016036,0.02011304,0.042991944,-0.007973789,0.004900771,-0.08420613,0.00014969216,-0.000714559,0.036420736,0.08642689,-0.023579342,0.028929364,0.07375894,0.003395215,0.050824087,0.045550715,0.09741437,-0.029638162,-0.031944513,0.062842816,0.0016379859,0.07843737,-0.035189476,-0.0027150498,-0.03261278,-0.027323106,-0.064616755,-0.019386083,-0.003614757,0.009034124,0.040507123,0.053434446,-0.05227944,0.050296094,-0.09876313,-0.017010696,-0.040309936,0.09723824,0.105813116,-1.7993957e-08,0.028785702,-0.09492228,-0.025458025,-0.032958154,-0.018395964,0.084619135,0.013415192,-0.00010479627,0.1102944,0.039328806,0.023878831,0.0416585,-0.017178888,0.05973567,0.06453927,-0.018341351,-0.024615066,0.0040614037,-0.016355202,0.00702142,-0.010834695,0.0111402795,-0.0012487716,0.009495611,0.022178067,0.027372165,0.0017497846,-0.047776826,-0.0210248,-0.06116085,-0.00033317087,0.030861108,-0.012133413,-0.09617541,-0.01069815,0.07840893,0.0542489,-0.030803885,-0.05276984,0.017684039,-0.0050797258,0.02509206,-0.109584905,0.006026348,0.012833139,-0.020215685,0.013186039,0.119689025,-0.05961564,-0.07459989,-0.04184507,0.020418046,-0.012473562,-0.041026995,-0.051568758,-0.00893825,-0.055236664,-0.01527889,-0.045739975,0.02272791,0.042370535,0.02054589,0.07977227,-0.0334902 +2.2.1.5,The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate.,384,1.0,-0.0477686,-0.058527052,-0.0026769359,-0.0508761,0.019679261,-0.03199049,-0.06069808,0.014093793,-0.03360836,-0.004443925,1.8655337e-05,-0.03438851,-0.06254245,0.08844234,-0.042408068,0.013565942,-0.01828606,0.011921537,0.0133764995,-0.0032294441,0.08876935,0.08253922,-0.09285697,-0.06585953,0.03167546,0.021896355,0.036701,-0.06084661,-0.024635956,-0.11783288,-0.038911104,-0.015360839,0.025711656,-0.064713486,0.07324318,0.10151361,-0.051407043,-0.049120788,0.10888822,0.0145037845,0.0004593847,0.03719667,-0.00034519532,-0.03494719,-0.02554147,0.0032597263,0.10467137,0.02496975,0.04156385,0.016094973,-0.049107518,0.035440512,-0.025366709,-0.023009654,0.0105412565,-0.097667724,0.025345786,-0.020268584,-0.07972252,-0.023956252,0.020730749,-0.0092171095,-0.0069477195,-0.036327947,0.03012873,-0.07716235,0.0035011221,-0.028623737,-0.0038870783,-0.0011393559,-0.090987936,-0.025513967,0.054301467,0.015423339,-0.045256488,0.015411706,0.0003031237,-0.069522,0.122552864,0.050833385,0.016747246,-0.010742082,0.0152617665,0.08889141,0.059352502,-0.00661408,-0.017491648,0.013302411,0.010152496,0.009003922,0.054825142,0.022499511,-0.019533293,-0.039153572,-0.03749197,-0.020525178,0.007178473,0.042573288,0.025112424,-0.031114055,-0.024818616,0.0019619684,0.0015277638,-0.09713364,-0.06040568,-0.024155065,0.034712017,0.055858113,0.046694525,0.05701873,-0.023541378,0.009173087,0.033324216,-0.00080142054,-0.03667982,0.07994595,0.025962992,-0.07389801,-0.10690561,-0.038506955,0.015394715,-0.014696814,0.09474432,0.0048452937,-0.07419615,0.046393182,-0.06062797,5.843752e-33,0.04526041,0.06260358,0.00070948934,-0.028000234,0.04150033,-0.002896449,-0.075599745,0.040761642,-0.036399584,-0.0099003585,-0.028329257,-0.045303494,0.026203295,-0.00086638395,-0.006521612,-0.008234046,-0.025493888,-0.011347492,0.041381184,0.011797998,0.0365363,0.035313,-0.05635999,0.061522834,0.039813202,0.004821184,0.055369847,0.064812385,0.012590925,-0.01005775,0.06478525,-0.115968406,-0.052505266,-0.049770217,0.08539879,-0.04040148,-0.048638802,0.00027918763,-0.041388936,-0.013783928,0.043014202,0.072698094,0.011954351,-0.012200868,0.04843062,-0.059344545,-0.02703383,0.1298988,-0.0093450835,0.037869584,0.041545328,0.009997526,0.02291617,-0.09797902,-0.040293228,0.019977191,-0.010021161,0.034278065,0.094705775,0.018565288,0.004711696,0.021524725,-0.029067114,-0.0096666645,0.008183458,0.03832526,-0.024061672,-0.0063571,0.012310762,0.08038731,-0.023124462,-0.04371947,0.030329151,0.049578663,-0.047958765,-0.07620874,-0.03496795,0.021414269,0.10388352,-0.11152687,0.053867295,-0.0063902424,0.007463665,-0.055807408,-0.049483396,-0.0710015,-0.02466378,0.053283095,-0.01860757,0.057223618,0.09665871,-0.088793315,-0.065207794,0.014065551,-0.0031599663,-6.2896956e-33,0.103660606,-0.143082,0.06048108,-0.0755261,-0.04244621,0.050376322,0.052489396,-0.037322644,0.07196413,0.010926934,0.039053638,0.012672561,0.047738742,0.037783362,-0.0034116572,0.06202013,-0.026317626,0.07013706,-0.01718523,-0.013844367,0.08094251,0.07463982,0.04851867,-0.03123452,0.014220195,0.04099837,-0.004988962,0.05019332,0.053477675,0.020726262,-0.035095844,-0.0064549423,-0.025895152,-0.074561276,-0.080782264,0.02065221,-0.027688561,-0.028032226,-0.033652816,0.005425847,-0.0069394913,0.027394054,0.007196846,0.10648016,0.033250105,0.030740414,-0.09987653,-0.054160163,0.04790805,-0.050346494,0.020632567,-0.030242834,-0.062204275,-0.017304745,0.0037741296,0.06401334,0.027684566,-0.02433697,0.009440174,-0.02639159,-0.06515855,-0.110261075,0.04375775,-0.03738009,0.042307537,0.052878767,0.0050734165,0.059361607,0.05019739,-0.053193,0.045995492,0.027263328,0.0354038,-0.016145803,-0.027402684,0.0150577985,-0.082240775,0.041744225,0.032792825,-0.015924342,0.005519961,-0.024572745,-0.02863453,0.011591442,0.02258148,-0.069673605,0.070476174,0.11141158,-0.039772157,0.06886938,-0.05577751,-0.016587524,0.0059904046,0.067598045,0.07600366,-3.8761304e-08,-0.033778958,-0.061467297,0.079885595,-0.027585495,-0.038085993,0.06596591,-0.007826338,0.036156747,0.06847221,-0.056647614,0.005861375,0.10255947,-0.06064262,0.032000616,0.038833592,0.017033784,-0.12257088,-0.00829847,-0.02558363,0.017792068,-0.05194077,-0.0023781739,-0.026039526,0.101253994,0.006681202,0.005933327,0.014420003,-0.001273338,-0.05414439,-0.016788853,-0.051233336,0.06729969,-0.022271754,-0.086088285,-0.15520515,-0.050740603,-0.017261,-0.034100883,-0.056048706,0.024468428,0.035203792,-0.027004957,-0.13796942,0.016179044,0.04142997,-0.005811444,0.0059268563,0.028739974,-0.07701973,-0.028467244,0.09287401,-0.016808128,-0.03408113,-0.017307537,-0.06831866,0.030381085,-0.010955711,-0.050682493,-0.027147036,0.029549059,0.015776154,0.04008251,0.21376884,-0.054742813 +2.2.1.6,"This enzyme requires thiamine diphosphate. The reaction shown is in the pathway of biosynthesis of valine; the enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.",384,1.0,-0.054756314,-0.015858637,-0.14106259,0.004434295,0.02313556,0.027822822,-0.04536493,0.010798765,-0.010655907,-0.008649826,0.0035596068,-0.10001127,-0.06256276,-0.062819295,-0.043211903,0.07865166,-0.03519316,-0.0036942225,0.038737934,-0.0772773,0.06040604,0.032566935,-0.034595706,-0.049713545,0.038954854,0.0009117073,0.034610808,0.007646758,0.01167101,-0.08477071,0.002932673,-0.07212193,-0.018175524,-0.091287084,0.018806523,0.11518261,-0.061986312,-0.025461651,-0.025748057,0.024561537,0.065837204,0.00266509,-0.044521477,0.009417841,-0.013145436,-0.036416322,0.0022341767,0.019128773,0.028257119,-0.012518276,-0.024992507,-0.04390235,-0.0644365,0.034564056,0.0069297873,-0.030401677,0.031941812,-0.0047045564,-0.03811413,0.011703569,0.052494776,0.031402208,-0.027708547,-0.026979845,0.0610133,-0.10678277,0.05614757,-0.101282366,0.012628677,-0.09646135,-0.079374775,-0.047867276,-0.00018393513,0.028374968,-0.033101283,-0.0786617,-0.06399294,0.021256719,0.063085146,-0.005848432,-0.0024370628,0.00021554556,-0.036259066,0.06121788,0.03974007,-0.006262614,-0.016698675,-0.016065942,0.036973704,0.08419965,-0.012221286,0.0030942052,-0.035445124,-0.020469302,-0.040306203,0.032577906,0.06147588,0.04149915,0.030773276,-0.011040899,-0.01071903,0.1030121,-0.08305471,-0.07385307,-0.053197518,0.004138901,0.011331931,0.060544696,0.03612085,0.041611288,-0.048788823,-0.02069698,-0.0018610815,-0.0042965394,-0.030756868,0.14857113,0.04254828,-0.075298935,-0.055414584,-0.019232163,0.036328934,0.023364047,0.063189,0.05399909,-0.0653499,0.01128371,-0.06673036,3.6432214e-33,0.08774673,0.08388468,-0.011486869,0.013680424,0.0006014266,0.028949065,-0.10423791,0.011347972,0.018363656,-0.056936502,-0.059781592,-0.09329105,0.08133429,0.014644907,-0.032809213,-0.046424508,-0.03884133,-0.005239094,0.080982514,-0.05784795,-0.031546853,-0.0033490183,-0.045020986,0.06324464,-0.060741734,0.043567646,0.03866324,0.050608814,0.017402545,0.017423252,0.010980983,-0.06856772,-0.06675293,-0.047147907,0.04288707,-0.051273875,-0.019747226,-0.013785849,-0.021853704,0.041875504,0.05604199,0.009707058,0.030919291,-0.031659458,0.032561805,-0.112132914,-0.0030362848,0.1134408,0.086996295,0.0330872,0.028404243,-0.051063683,0.12426873,-0.020101482,-0.04050149,0.07944034,-0.011864484,-0.009459365,0.048889093,0.004931642,0.022941265,0.08341411,0.0305524,0.048187584,-0.05405563,0.014548831,-0.07558381,-0.03733792,-0.0011828869,0.016416585,-0.06354227,-0.020146377,0.07628991,0.027762473,-0.001670592,-0.06089887,-0.05753041,0.014898217,0.008733013,-0.092600815,0.004967085,-0.007794471,0.10050008,-0.029470814,0.029512085,-0.06920568,-0.021110253,0.0040798807,-0.0429963,0.08354295,0.012647184,0.035093416,-0.048567493,-0.0057149096,0.105199985,-4.725855e-33,0.09600337,-0.0991327,-0.0054414766,-0.10033625,-0.010201388,-0.0019071626,0.013067527,-0.006749055,0.0082548205,0.040066935,0.074892595,-0.020155897,0.033601362,-0.02272986,0.03561724,-0.024759633,0.039242443,0.06737032,0.0027186049,-0.035989918,0.029995166,0.027845465,-0.0010441656,0.025673538,-0.005744912,0.009543366,0.010968893,-0.01665547,0.01109586,0.08208038,-0.0041483385,-0.026905714,-0.026659405,-0.0025746801,-0.0031912928,0.058392547,-0.006567427,0.0038587325,-0.048055276,0.07167039,-0.024876136,0.026559448,0.014524305,0.051667914,0.04769131,0.020958396,-0.04083026,-0.041835,-0.051180057,-0.08287099,0.094737105,-0.004544033,-0.048523106,0.0512994,0.022262068,0.0758279,-0.050124694,0.017361997,0.07032502,-0.05527577,-0.012885224,-0.03997364,0.0068333084,-0.06318962,0.05197534,0.06223198,-0.0032291156,0.075288884,0.018829945,0.03874078,0.09575961,0.03263946,-0.0029696212,0.028171374,-0.040561695,-0.054638453,-0.039349977,0.011497568,-0.017686348,-0.051912487,0.050427046,-0.013218048,0.040231142,-0.09980755,-0.067581244,-0.11327686,0.0036717386,0.1194152,-0.053836714,-0.002605561,-0.032349844,-0.022918211,-0.08982247,0.04366522,0.09309456,-4.00409e-08,-0.03313337,-0.060428776,0.062029522,0.029584276,-0.035692647,-0.0068846457,0.012219598,0.013511516,0.068772666,-0.066357195,-0.033475358,0.096027724,0.06598453,0.057469755,0.06453375,0.016960274,0.011816533,0.10429463,-0.027541712,0.023898013,-0.07592191,-0.009307713,-0.03096769,-0.010926856,0.035066955,-0.06908702,0.016687557,0.033990793,0.049005963,-0.054517668,0.04407732,0.04878607,-0.00625096,-0.094598226,-0.100184344,0.07993663,0.0014344809,-0.054497328,0.02273921,-0.041361533,-0.017006438,-0.011369829,-0.08796965,0.046237674,0.055605493,0.009937846,-0.01578568,0.033979207,-0.089945234,-0.022153744,0.018888382,-0.019238938,0.01539187,-0.032303523,-0.035140794,0.00550124,-0.015168023,-0.08442205,-0.0014684886,-0.038398124,0.06418154,0.06999606,0.19462891,0.038394548 +2.2.1.7,"Requires thiamine diphosphate. The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA}).",384,1.0,-0.00018571194,-0.036623534,-0.07669735,-0.035189204,-0.041113313,0.00527062,-0.07978253,0.007811541,0.03281328,0.008045302,0.045080055,-0.07490421,-0.020941382,0.0070540146,0.0010178456,0.01423636,0.0025639078,-0.01058863,0.085063435,-0.021862231,0.05467789,0.12529838,-0.020225998,-0.056274228,0.008434324,0.011978722,0.044525422,0.021542802,0.04884891,-0.04092591,-0.14349473,0.0596058,-0.04708252,-0.082779475,0.014806588,0.08516382,-0.12214457,0.03785982,0.033105366,-0.02274642,0.101754695,-0.017976882,-0.011334597,-0.051595587,-0.051783126,-0.045208618,-0.00648762,0.020130016,-0.012176835,-0.012216147,-0.064888775,-0.004903085,-0.020062188,0.016819932,-0.030889837,-0.048467427,0.07567626,-0.017980002,-0.08496467,-0.027391167,-0.0009886407,-0.03601136,-0.0073689697,-0.014852644,0.06338711,-0.041905276,-0.010827146,0.046098802,-0.01218548,-0.05201092,-0.060680665,-0.040394403,-0.005487386,0.027269857,-0.07323774,0.041239142,0.083115235,0.027835166,0.04723216,-0.023800906,0.04024048,0.022612508,0.013545594,0.1343787,0.08647643,0.0040771216,0.0016874336,0.008491949,-0.0027696479,0.07933154,0.06801505,0.057639774,-0.02221676,-0.0343888,-0.032804824,0.050677925,0.016822979,-0.01140028,-0.05194962,-0.058194872,0.036898766,0.0051056594,-0.06649814,-0.02567682,-0.048623525,0.04534072,-0.006805824,-0.028928712,-0.005876113,0.008534231,0.03580362,0.0060830335,0.053675056,-0.00064122025,-0.046045005,0.062270917,-0.0036141293,-0.08567714,-0.026330968,-0.01332202,-0.052736767,-0.0062184893,0.017437082,0.10172817,-0.06150232,-0.017219309,-0.037050217,1.772269e-33,0.100817144,0.09381824,-0.0056019127,-0.10267263,-0.022251012,0.026257992,-0.064261995,0.028279364,-0.054166205,-0.038200475,-0.045346625,-0.109834634,0.04208753,-0.055897463,-0.013238943,-0.09565433,0.010624685,0.06409123,0.09359449,-0.017515177,-0.033079978,0.055280186,-0.06034946,0.0008398546,-0.014416114,0.08372269,0.017548762,0.026559796,0.02193276,-0.022264823,0.048801176,-0.0862201,-0.030255014,-0.054750845,0.12036896,-0.05517211,-0.018091952,0.01813142,-0.100057766,0.021507071,0.033951998,0.06992866,0.0012024852,0.0047101188,0.058392655,-0.10443319,-0.030168412,0.03907077,0.027256705,0.048155338,-0.0074012424,-0.00069269544,0.08286953,-0.04118649,-0.06711483,-0.038334705,-0.004945995,0.023433536,-0.01601347,0.014185041,-0.0097446665,-0.015279356,-0.09129735,0.049511805,-0.07143504,0.05224812,-0.12619442,-0.05019102,0.010495028,0.047196507,0.004792871,-0.007821965,0.09100362,-0.017667608,0.04926773,-0.005894066,-0.039746895,0.044311997,0.036427125,-0.023952264,0.029021893,-0.018750165,-0.039096713,-0.050852302,-0.019121857,-0.04280032,0.039879896,0.018350562,0.02646753,-0.0017006953,0.10374721,-0.010808675,-0.08350573,0.018072885,0.019908477,-2.9188522e-33,0.06966352,-0.07208322,0.042490233,-0.09622754,-0.014158763,0.02105028,0.00435098,-0.048815303,0.030221062,-0.025466109,0.054440957,-0.0054515386,0.046422884,-0.056309577,-0.028360425,0.012794676,0.016720861,0.11566394,-0.0046366565,-0.05238245,0.028836353,0.0758344,0.0012625109,0.068004996,-0.0558948,0.019011203,-0.025973894,0.031013438,-0.03427847,0.12291685,0.007232574,-0.006812045,-0.07103311,0.0155126825,-0.030923177,0.06662438,-0.040414117,0.004051872,0.027752187,0.10573514,-0.034501858,0.02560055,0.014265484,0.058253393,0.018845024,0.03882196,-0.11431703,-0.018038906,0.0009650292,-0.068548106,0.08649243,0.012031209,0.02274745,0.0121447835,0.02155688,0.0028223458,-0.018321943,-0.0035901675,0.06143487,-0.059256904,0.011111632,-0.08346379,0.007929206,-0.06355498,0.011883893,0.037652716,-0.039755736,0.0629034,0.05624091,0.006870243,-0.02762691,0.114399806,0.04361221,-0.04533083,-0.0032132368,0.018013975,-0.021130469,-0.06392442,-0.0008361538,-0.027493436,-0.014648844,0.048778955,-0.011265428,-0.06057752,-0.052045066,-0.020131033,0.053351272,0.023458509,-0.026691614,0.07035142,-0.0355928,-0.022061465,-0.020770622,0.11253051,0.09238853,-3.3403893e-08,0.012292316,-0.04642854,0.0148933865,0.014218829,0.005798716,0.041244727,-0.0024652428,-0.06234051,0.12183882,0.04062773,-0.026466047,0.03638215,-0.0050762985,0.064936936,0.15654914,-0.023339726,0.0010103456,-0.0154174995,-0.033494975,-0.06628298,-0.034425374,-0.023098668,-0.09223223,0.002231432,0.05814415,-0.047663186,-0.027660783,-0.083043225,0.0045001977,-0.047908973,0.025815517,0.02635229,-0.053248383,-0.050475493,-0.0713257,0.096134976,0.007379468,-0.029089984,-0.030377442,0.058978133,-0.010253551,-0.009561836,-0.11945053,0.027160704,-0.008217448,0.028354414,0.016507836,0.06622905,-0.072939225,-0.01257176,-0.029269125,-0.020959154,-0.016595503,-0.029267052,-0.022312103,-0.006212119,0.022378638,0.0068538464,-0.049159534,-0.014981873,0.048382375,0.070987985,0.1898572,-0.057497595 +2.2.1.8,"A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.",384,1.0,-0.024954522,-0.05527037,-0.07912878,-0.1013815,0.04119476,0.024378268,-0.039599556,0.02436675,0.05272877,-0.027514923,0.036194645,0.015670534,-0.07251847,0.068954825,0.007880386,-0.004517202,-0.0031219416,0.0434952,-0.004354592,-0.032231346,0.044418454,0.0051715816,-0.053996656,-0.009819653,0.030584887,-0.0013507387,0.0028163453,0.05725185,0.03335451,-0.050631996,-0.017452732,-0.014908837,-0.05328598,-0.10398754,0.055620633,0.11014434,-0.06051659,-0.029035192,0.044874456,-0.016813822,0.039698575,-0.022818564,-0.022357168,-0.022843223,-0.04814967,-0.011451124,0.098452024,0.014402045,-0.0048709605,-0.023295568,0.023643468,0.012253022,-0.098086804,-0.06168005,-0.003495727,-0.028371003,-0.050382227,0.04925256,-0.013949451,-0.059256308,-0.03762092,0.00621131,0.0066774553,0.0036199684,0.024526358,-0.07846926,0.06292649,-0.08128527,0.034249812,-0.05895588,-0.0978622,-0.058804303,0.073481485,0.070643686,0.004029519,0.05426064,-0.08994065,0.053572733,0.066203356,0.013025755,-0.0008820605,-0.027901048,-0.002131097,0.07053875,0.04264544,0.02517939,-0.02426359,0.009916544,-0.053656217,-0.031883046,0.029018683,0.023663783,0.06384675,-0.011602656,-0.015918525,0.052202083,-0.0042890552,0.023588905,0.0018217402,-0.03461745,-0.02378949,0.09973413,-0.061378494,-0.03483962,-0.059373796,0.0010638293,-0.026183795,0.08539173,0.025308514,-0.035325464,-0.05942383,0.044399202,0.02452941,-0.013482448,0.012356439,0.05568715,0.055708285,-0.04525583,-0.008130343,0.022972986,0.024570849,-0.019226328,0.06312783,0.120618105,-0.01878512,0.07104695,-0.046496745,4.5466222e-33,0.06306332,0.0903926,0.078443475,-0.028715784,-0.017450482,-0.015687738,-0.14269358,0.012469317,0.011864879,-0.08946941,-0.019772166,-0.016653297,0.055153657,0.018088905,-0.012865344,-0.01300598,-0.08343584,0.009140241,0.0859085,-0.0035188585,0.01911028,0.029101957,0.032563698,0.08378543,0.054208133,0.024384698,0.033439666,0.027917363,0.014253363,0.014034132,-0.050281122,-0.13410774,-0.10200761,-0.03113267,-0.022775821,-0.047633283,-0.05539647,-0.08079426,0.07005483,0.03259708,-0.008064668,-0.0009910545,0.01995868,-0.021532223,0.025789054,-0.020249868,-0.003612916,0.05377352,-0.03274765,-0.007181956,0.042853445,-0.06299903,0.028883897,-0.037338722,-0.09761075,-0.006562325,0.05764129,-0.006350811,-0.015775092,0.09321849,0.03240505,0.085070536,-0.016704228,-0.055970352,0.0010786363,-0.06365253,-0.039707508,-0.00536375,-0.00200478,0.024289135,0.023190692,-0.03353634,0.115167454,0.02872329,0.030456366,-0.09413943,-0.038662713,0.00548688,0.013210649,0.0016600027,-0.008769039,0.053472027,-0.01231551,-0.07531297,-0.054442935,-0.044852916,0.048167393,-0.11503861,0.037342813,0.019774744,0.015093958,-0.08518321,-0.026176833,-0.034747925,-0.078375205,-4.1028353e-33,0.032378953,-0.09015254,0.04328882,-0.019994214,-0.0050298776,-0.061587956,0.06378784,-0.038020868,0.06497087,0.0056584873,0.085148044,-0.0068108044,-0.0042632357,-0.024394626,0.0502288,-0.015038671,-0.035711095,-0.00079819816,0.035386525,0.011779263,0.038724914,-0.0051105483,0.020879826,0.06872839,0.05191322,0.0673108,-0.035115518,0.06922116,0.08552359,0.04251902,-0.059670806,0.026141122,-0.002683431,-0.042486288,-0.04758652,0.004771241,-0.04923429,0.019529983,-0.055062152,-0.017119631,0.017366884,0.040981375,0.0022754052,0.0024407352,0.01940136,0.08635252,0.0017877317,-0.011729687,-0.0015206196,-0.048068196,0.06523646,0.08628295,-0.068217136,0.08061492,-0.0084277475,0.033401117,0.030136568,0.01620486,0.0034045866,0.0035494214,-0.04013723,-0.08231744,-0.015542762,-0.008608651,0.040618848,0.047871932,0.0026269322,0.072399125,0.04842642,0.09051254,0.09980509,-0.04697378,0.084253095,0.057989646,0.01531434,0.0027068455,-0.042042043,0.030281922,-0.010264625,-0.044065677,-0.02114421,0.024308007,-0.022466606,-0.03713536,0.07488797,-0.0698879,0.008270996,0.111500554,-0.026141267,0.037675932,0.0038092986,0.014365878,0.013928422,0.10918568,0.07929351,-3.7920387e-08,0.02182055,-0.08381988,0.06494048,-0.017516326,-0.034324385,-0.007158984,-0.010087264,-0.018378899,0.039214846,-0.034738332,-0.0690808,-0.010111388,0.012228648,-0.051587258,-0.030676654,0.12848191,-0.034782123,0.042076968,-0.005040541,-0.011627551,-0.12837762,0.06150228,-0.17065181,0.0067083,-0.019224374,-0.0044474467,-0.033619843,0.017468259,0.013345547,-0.030090874,0.061864983,0.03824014,-0.0020193737,-0.057778332,-0.089979604,-0.019587915,-0.0131860105,-0.007813851,-0.011730298,-0.0012379384,-0.036261104,0.005550099,-0.066909574,0.028603312,0.08838107,-0.0076455073,-0.008557136,0.0009671039,-0.046893563,0.014450154,0.07603423,-0.02432702,-0.023083627,-0.12529826,-0.09458288,-0.011581259,-0.05645904,-0.074688055,0.022675069,-0.07297542,0.0019038758,0.0005869522,0.21998477,-0.008808227 +2.3.1.1,"Also acts with L-aspartate and, more slowly, with some other amino acids.",384,1.0,-0.027094768,-0.17117602,-0.042019412,0.05823876,0.07683443,0.06770247,-0.05789703,0.06750731,0.06262878,-0.006857748,0.06452548,0.020105649,-0.062009756,0.06684516,-0.016713895,0.031024788,-0.01487135,-0.04336832,-0.05554373,-0.037698478,0.050925817,0.038057745,-0.022980573,-0.008888679,0.064266145,-0.016185084,0.017007817,-0.04664348,0.048746064,-0.1048035,-0.010848193,-0.014393474,0.027175143,-0.026536196,-0.030653195,0.0730857,-0.064256206,-0.080774374,0.020317005,-0.031141255,0.06511963,-0.0491983,-0.00021000937,-0.07448454,-0.011230694,0.004940818,0.006030563,0.021104934,0.021745762,0.019375946,-0.05357604,-0.0671368,-0.06958011,0.0452299,-0.11069851,0.037797783,-0.14350784,0.01866083,-0.0068129594,0.010779193,-0.11663011,0.053990573,0.0014914867,0.026359431,0.086755365,-0.017156225,0.018728174,-0.050282348,-0.027859788,0.01775782,0.03860236,-0.027662493,0.0353365,0.07658997,0.04312812,-0.055952094,-0.015212891,-0.02731044,0.00927936,-0.008351898,-0.01589443,0.074374035,-0.032767907,0.06737768,-0.017501138,-0.010036124,-0.021262193,0.0145737585,-0.035210196,-0.0005261833,0.021620935,-0.00562423,-0.06072121,0.024474783,-0.0111535415,-0.010323153,0.090269566,0.012123641,-0.030835994,-0.028057506,-0.050697643,0.07639832,-0.057515237,-0.041026153,-0.033968095,0.0054610064,-0.00033010135,0.019433806,-0.016907945,-0.022393296,0.05449757,-0.027453078,0.054236654,0.023396881,-0.058526266,0.026304364,0.038836464,-0.028559903,-0.05149143,0.012730564,0.028420625,-0.030037744,0.036220077,0.066198654,-0.036758903,0.09434943,-0.050440725,-2.1287488e-33,0.0711263,-0.049554642,0.036340527,0.0056132283,0.0068794033,0.01698367,-0.08868763,-0.011432531,0.046021834,-0.051089995,-0.07005495,-0.1076172,0.03660034,0.0419056,-0.07593237,-0.042403974,-0.049208697,0.011061316,0.024376033,-0.0106097255,0.010809857,0.10196057,-0.020681504,-0.00268714,-0.013143535,-0.012568561,0.021597637,0.0050790426,-0.014230414,-0.0008007278,-0.031065458,-0.009760099,-0.10995687,0.01724211,0.07149946,0.05301836,-0.016386043,-0.08416342,0.038109533,0.028590309,0.03792482,0.04524916,-0.08865867,-0.040789552,0.05118255,-0.035449453,-0.039877303,0.03645647,-0.044648148,0.03048165,0.12696749,-0.046023976,0.06490535,-0.016495863,-0.039181557,0.0051176595,-0.028262492,-0.0046594534,-0.01850489,0.11599778,0.0039171493,0.010117111,-0.019782193,0.070658185,-0.012482206,0.025203316,-0.09518,-0.05336128,-0.024129428,0.020171821,-0.086987846,-0.07561827,0.12980634,0.0011298158,0.0013227992,-0.06747438,-0.049990103,0.012276151,0.0031159373,-0.0045795524,0.037887435,-0.071930185,0.029666232,0.029788464,-0.03795508,-0.026713835,0.062290546,-0.10440967,0.018965803,-0.030913966,0.039015707,-0.07882132,-0.030901834,-0.012982164,0.020245874,-9.027701e-34,0.035950687,-0.1494826,0.0540595,0.035954352,-0.041018993,0.0345732,0.05200167,-0.009117646,0.03243947,-0.021307673,0.0839823,0.01655477,-0.061279926,-0.0305625,0.036016755,0.047565527,0.052801717,0.10764244,0.018275244,-0.0063286894,-0.03176027,0.083144896,0.042221863,0.029752217,0.10218347,0.008624568,-0.034795474,0.0438704,-0.0010361456,0.04468319,0.013548128,-3.1345706e-05,-0.09481311,-0.12752658,-0.03765585,0.04724206,-0.03607262,-0.04739169,-0.0074640084,-0.08357835,-0.008763974,0.010329243,0.114066824,0.059949655,0.051900357,-0.0074125687,-0.0047712345,-0.036645126,-0.08752144,0.00569375,0.029720657,-0.06702832,-0.033793766,0.032924555,0.007138806,0.011549513,0.0061550224,-0.0334739,-0.04101549,-0.0146735795,-0.06431359,-0.07481161,0.0035410845,-0.030354284,0.04636483,-0.028723355,-0.019117132,0.01374156,0.09481245,-0.00018674992,0.09858228,0.027631717,0.03713762,0.0938664,-0.02538269,-0.05240666,-0.017254673,-0.04864442,0.024725527,-0.05010272,-0.14917484,-3.3199565e-05,-0.002878126,-0.09308047,-0.043297756,-0.040962126,-0.052416485,0.07217703,0.010290155,0.0857988,-0.032494757,-0.060581833,0.033873174,0.047292456,0.08685437,-2.2917185e-08,0.068813756,-0.0158644,0.034495685,-0.0100085195,0.029926147,0.03991578,0.010283046,0.025841342,0.0038055612,-0.052065868,0.02235072,0.0650524,0.06588032,-0.0031354944,0.04518826,0.04453433,-0.011337941,0.06830443,-0.0405245,0.024433367,-0.08859315,-0.0030128197,-0.060045607,0.024851462,0.0007788755,-0.04723109,0.016884787,0.105555326,0.024527058,-0.06648991,0.04982899,0.0015565471,0.060122535,-0.08678626,-0.021507593,0.036959663,0.037342597,-0.017780432,0.05039929,0.02764653,-0.014865521,0.039212827,-0.013586543,0.016151465,0.0031568403,-0.0015590719,0.0073843407,0.023698976,-0.026990935,0.02054516,0.057038013,-0.013751671,-0.050229784,-0.02850368,-0.069470756,0.0009820021,-0.032484792,-0.06023251,0.08815795,-0.0810356,-0.030053109,0.052055776,0.16087829,0.043879565 +2.3.1.2,Also acts with propanoyl-CoA.,384,0.99999994,-0.08442408,-0.08324512,-0.037926663,0.057156593,0.05833606,0.060349714,-0.05876686,0.053887717,0.003226085,0.040224317,0.055259023,-0.05428304,-0.10369909,0.11357897,0.03507524,0.08899747,-0.006476574,0.025614096,0.05219803,0.047403753,-0.015617841,0.05534313,0.025523858,0.0664351,0.02633147,0.042261556,0.022320412,0.045527507,0.05664936,-0.054743007,-0.010062214,0.0075540347,-0.003971689,0.006255242,0.057535563,0.0027703766,-0.075282834,-0.019934347,-0.014137994,0.014160123,0.07797411,-0.090266585,0.011482365,-0.012344402,-0.01528475,-0.034039307,0.007451054,0.044760585,0.076731905,0.06311823,-0.0472053,-0.060513053,-0.07900174,0.084229566,-0.049013328,-0.006834185,-0.09176148,-0.0075571868,0.067844965,0.014997758,-0.027089272,0.025776,-0.10569414,0.049946282,-0.0074803946,-0.0068447823,0.024598677,0.004945577,0.05252659,0.009427131,0.043540817,-0.042324703,0.04147632,0.039720252,-0.0039366013,0.008121276,0.0424131,-0.09404634,0.015666617,-0.028388971,-0.0510986,0.07764427,-0.03551626,0.0071733324,0.024327723,0.040407818,-0.014131858,-0.035525873,-0.108002186,-0.014321976,0.03590787,-0.04350626,0.013299239,-0.025982507,-0.034154974,0.050296087,0.021713587,0.005206025,0.0033991027,0.0056282864,-0.09909838,0.056970082,-0.0776161,-0.082156934,-0.027272819,-0.00072773354,-0.011641011,0.009434099,-0.02273606,0.050634228,-0.012002495,-0.022109844,0.03581337,0.009492884,-0.005218128,0.044007674,-0.010421326,-0.006718142,-0.025019059,0.039125994,-0.016358886,-0.06388485,-0.01464864,0.05408058,-0.0020053273,0.00291143,-0.008352786,-2.857372e-33,0.11643594,-0.031199183,0.023962704,0.013530578,0.050568506,-0.026426231,-0.04992962,-0.03142169,-0.033131555,-0.047956385,-0.019022629,-0.047456697,0.0007981922,0.09034185,-0.098706715,-0.026062505,-0.0055822656,0.045272008,0.028303701,-0.030352369,-0.00419784,0.14111283,-0.037161816,0.019893745,-0.061319303,-0.013788297,-0.070091344,0.07109406,0.03693978,0.011662307,0.024693193,-0.034072798,-0.03941105,0.07315462,0.028690467,0.034414627,-0.09387464,-0.091028504,-0.038925853,0.09894859,-0.018410718,0.03578792,-0.14331228,0.003301836,0.04033861,-0.08559558,-0.029188566,0.0628759,-0.00029312237,0.002709613,0.10021249,-0.021665772,0.07854606,-0.03857393,-0.022706922,0.03963546,0.015943034,-0.01916,0.044695325,-0.010594203,0.011366809,0.065121375,-0.015212873,0.06983444,0.040912207,0.008001392,-0.12389358,-0.039591163,-0.013334927,-0.013470965,-0.04541702,-0.00031928392,0.0442676,-0.0022337968,0.02256112,-0.029669186,-0.0011953058,0.014257338,0.021997768,0.016530177,-0.02934487,-0.11133168,0.056157645,0.034148216,-0.032321893,0.023160808,-0.015410878,-0.10132695,-0.0025335064,-0.013827068,0.080994554,-0.07093103,-0.03911206,-0.03199811,0.008236059,1.15252115e-33,0.07621296,-0.10423439,-0.0032876004,0.016251588,-0.08318805,0.05083382,-0.035752214,-0.06681333,0.041354198,-0.0075888135,0.11600041,-0.024890075,-0.018689055,-0.05894727,0.043123085,0.0573528,0.08652902,0.08432558,-0.042315885,-0.0050393334,-0.016847396,0.0441609,0.016354587,0.022491815,0.045093413,-0.04087792,-0.039837644,-0.01007277,-0.028301224,0.06144282,-0.019962566,0.0048751943,-0.12204376,-0.07490281,-0.006418953,0.0199967,-0.03180884,0.023141807,-0.020722702,-0.07329773,-0.031742446,-0.018741049,0.06777395,0.09649373,0.042311285,-0.01692166,0.0400094,-0.03603219,-0.08121904,-0.008065341,-0.030254945,0.0007056,-0.049041193,-7.399129e-05,0.043999456,0.07401187,0.026205255,-0.08576437,0.012888055,-0.067869365,0.01775955,-0.050118417,-0.02713166,-0.08393255,0.13613456,0.045861457,-0.08164314,0.007416295,0.11809678,-0.025850719,0.113872506,0.06012508,0.029055169,0.029632745,-0.06567538,-0.057477545,0.033893544,-0.09981031,-0.045972,-0.002020239,-0.06933939,-0.025243193,0.0031978015,-0.046447776,-0.09218994,0.018232768,-0.011712622,0.02892074,-0.009178796,0.07372338,-0.045834832,0.022673383,0.021697128,0.08158566,0.033595424,-1.642137e-08,0.031913664,-0.009246497,0.077280864,0.006626302,0.021429373,0.006845054,0.07999065,-0.0013751352,0.0053805085,0.019570885,-0.015529867,0.07300202,0.10884686,-0.020601006,0.097900845,-0.04430102,0.0602569,0.009577732,-0.087524764,-0.05454903,-0.09224716,-0.066846386,0.029789262,0.04476109,-0.021786518,-0.044683624,0.02202851,0.08514811,0.031148504,0.0066593015,0.033224203,-0.0749532,-0.05953437,-0.04141151,-0.011882057,0.032062326,0.098977946,-0.03023507,-0.047131307,0.053218815,0.0069126473,-0.0048822826,-0.03543566,0.06260817,0.026816122,-0.003946549,0.027177367,0.03048725,-0.03866103,-0.0020152307,0.06729269,0.0013015514,-0.06576167,0.011890247,-0.05046111,0.032549195,0.025327325,-0.0052409195,0.012518245,-0.04119401,0.0037463133,-0.002962873,0.14223452,-0.0062454734 +2.3.1.5,"Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.",384,1.0,-0.039990958,-0.09860901,-0.065167196,-0.016008059,0.026525468,0.06931098,0.0009711313,-0.062326048,0.017187938,-0.001974069,0.015553766,-0.012027004,-0.07526692,0.047165364,0.009658612,0.044017203,0.006203858,-0.063861504,-0.008734644,0.026512163,0.022721544,-0.011102018,-0.040482335,0.03630446,0.00023782978,0.08741365,-0.011139018,-0.032713976,0.037487682,-0.012666224,0.019099692,-0.013787023,-0.055871263,0.0153801255,0.016719913,0.007000138,-0.017336072,0.008002623,0.03970713,0.01452199,0.018315945,-0.02900172,0.0024644125,-0.06400572,-0.050794933,-0.07739515,0.022647299,-0.03609304,-0.026658535,-0.06617501,-0.0017428306,-0.0005649921,-0.048395112,0.088599704,0.0047278833,0.03074282,0.014274059,-0.030913005,-0.08238643,0.049718637,-0.05988818,0.04850604,-0.052984267,-0.045214184,-0.0045589465,-0.0331336,-0.0077870577,-0.0120017845,0.041982368,0.022811737,-0.026087563,-0.06890245,-0.07451013,0.039198454,0.06772049,-0.075804785,-0.030840257,-0.031997826,-0.031217525,0.035650067,-0.056234147,0.04335735,0.023863753,0.10028505,0.09178989,0.07382747,-0.012950152,0.017137261,0.03519714,-0.017045975,-0.011169054,-0.07224928,0.02021178,-0.035990156,-0.049008608,-0.03188377,0.09144938,-0.033670872,0.037729476,0.04055867,0.028647881,0.026493447,-0.10181884,-0.021702766,-0.057957392,0.006014536,0.099470876,0.060967475,0.0022460683,-0.04782347,-0.05458189,0.0034630713,0.0766726,0.03627791,-0.03058071,-0.002629747,-0.06890386,-0.032459848,0.038401976,-0.0065768696,-0.041293107,0.053569905,0.07271461,0.12768148,0.0154575175,0.06158269,-0.0681629,2.0685119e-33,0.071186036,0.025831152,0.09175678,0.03718111,-0.056729063,0.043968588,-0.04629925,0.009031813,0.09013163,-0.063730694,-0.07891545,-0.03203285,0.041519985,0.04459473,0.05929329,-0.03559913,-0.05632147,0.011523106,0.14502686,-0.026853275,-0.0140416995,0.06823028,-0.031801492,0.04753802,-0.05121445,-0.037830118,-0.08430902,0.099370375,-0.009024385,0.018568357,-0.02850443,0.0654657,-0.013267901,0.0051423884,-0.037681226,0.042521387,-0.115381986,-0.016115857,0.04184521,0.07021143,0.054990612,0.057123832,-0.037129723,0.013247568,-0.06741567,-0.009841559,-0.05986927,0.032761436,-0.040249716,-0.002339261,-0.016129997,-0.011887912,0.07629498,-0.021711318,-0.06680525,0.02587823,-0.0012590098,-0.07371339,0.04751304,0.009270233,-0.042176712,-0.015110882,0.019258218,-0.05148461,0.0007733148,0.028674986,-0.015376985,-0.018983549,0.035954528,0.040259644,-0.03806342,0.03387057,0.060006313,0.024193536,0.09901488,-0.0757312,-0.066114284,0.015475152,0.13625191,0.047469933,0.022904601,-0.035708454,0.0029101598,0.015462941,-0.037618335,-0.046712928,0.07674721,-0.03049289,-0.045666076,0.11413599,-0.0014745668,-0.09897939,0.043579552,-0.045538463,-0.0022045544,-3.2111787e-33,0.04735338,-0.106341854,-0.016516527,-0.062428515,-0.06388346,0.058695946,0.05907205,-0.06627112,-0.011102116,0.05856558,0.13008228,0.05596227,0.00033689587,-0.020595804,-0.035025198,-0.037407033,-0.03190895,-0.042544056,0.070225455,-0.010491927,0.02624529,-0.04705096,-0.04726327,-0.016196212,0.09532597,-0.0135762375,-0.050606403,0.016310858,0.008654745,0.008010209,-0.011391171,0.0010118039,-0.06287595,-0.047586743,-0.025157187,0.090939194,0.0023802735,0.033368304,-0.09973286,-0.036452267,-0.012487282,0.01995587,0.055599567,0.09190877,0.01889583,0.02586043,-0.109163806,-0.069595605,-0.06413418,-0.059157994,0.010138189,0.009434833,-0.021452338,-0.06903487,0.0023705042,0.014430006,-0.039026868,-0.04161694,0.03183206,-0.051606987,-0.060558636,0.059852183,-0.108619675,-0.057457417,0.017341843,-0.02475589,0.010258468,0.015062179,0.04966289,-0.0708147,0.10344575,-0.026898673,0.19501854,0.05667814,-0.017560951,-0.11286061,0.020500408,-0.05490353,-0.03954615,-0.08889708,0.028514206,-0.040626273,-0.00017123952,-0.04302433,-0.086990274,0.007936258,0.051547408,0.01789076,-0.048105914,0.023908818,0.0010732424,0.032613188,0.059787825,0.03069334,0.061743468,-2.459399e-08,0.018710487,-0.07995563,0.016773315,0.0032989401,-0.028109834,0.06258673,-0.017471043,-0.015352404,0.03098368,-0.022654487,0.04716473,0.08274532,0.053831864,0.088661686,-0.017558431,-0.008818689,-0.013012528,-0.0348096,-0.0005053402,-0.07407498,-0.101925485,0.067821756,-0.064727545,-0.00852636,0.035246603,-0.038533583,-0.010773345,0.05804159,-0.027954804,-0.07076634,0.022850996,-0.015217743,0.02798973,0.0334711,0.08253161,0.040363517,0.028638711,-0.061710577,-0.033023737,-0.026211271,0.022119885,0.016636977,-0.07921194,-0.0016724085,0.13379093,0.03299061,-0.003941636,0.02701769,-0.011014705,0.013622414,0.052908137,0.04461009,0.021516694,-0.015716298,-0.046644047,-0.0371187,-0.022113027,-0.049836643,0.01971911,-0.03420956,0.06657232,0.053713087,0.08057097,0.02222223 +2.3.1.6,"Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.",384,1.0,-0.074313,-0.113499865,-0.05164494,0.042997383,0.06152471,0.043970544,-0.121424064,0.046937652,0.02640518,0.010908042,0.07008252,-0.02352927,-0.085989855,0.049599554,0.013921345,0.04672027,0.050422173,-0.007538326,0.0022042072,0.039028917,0.0018549868,0.007008533,-0.029697388,0.057609916,0.037622206,0.030086245,-0.029183311,0.057426807,0.03276134,-0.087987974,-0.011409374,0.020761088,0.009736856,0.012140035,0.06249545,-0.030092837,-0.056665536,-0.00059672707,0.037067775,0.020375976,0.056637473,-0.10176607,-0.056496944,0.0001145213,-0.013495294,-0.051912516,-0.008604573,0.013893562,0.047560897,0.014998289,-0.059720263,-0.034328073,-0.09160361,0.025174174,-0.046068616,-0.018399008,-0.07763659,-0.010705773,0.059917066,0.01981736,-0.0062397793,0.017921373,-0.08928705,0.04312175,-0.0050415597,-0.015528436,0.07102449,-0.007440722,0.08195381,0.08082865,0.025882754,-0.008599215,-0.0061856676,0.074325785,0.017908568,-0.07692318,0.033121068,-0.10428329,0.044560626,0.017398918,-0.047086373,0.07141223,-0.06358748,0.013432663,-0.032834195,0.042178866,0.0078053456,-0.058231015,-0.109766915,-0.04739154,0.042450525,-0.019598091,0.052036375,-0.04882032,-0.016649075,0.05459821,0.053970367,-0.03012545,-0.010145804,-0.0020063575,-0.062860414,0.09721688,-0.08826456,-0.054012,-0.031088777,-0.01463446,0.031260863,0.049701598,-0.022997124,0.08799139,-0.010208739,-0.04139138,0.03467574,0.0030100623,-0.037740596,0.051235672,-0.07135783,0.0139145795,-0.0014358544,0.08003013,-0.023003273,-0.025575453,-0.024604183,0.046188913,0.06956649,0.021693401,0.03957609,-1.2852668e-33,0.08688453,-0.01873062,0.01973418,0.0038660422,0.012943074,-0.074738316,-0.049763344,-0.006527891,-0.009393697,-0.03134955,0.021511924,-0.05684694,-0.029289288,0.090573885,-0.052784696,-0.047481943,-0.016934603,0.01815024,-0.0065357876,-0.0034935195,-0.037903428,0.050686378,-0.005604327,0.017268622,-0.026938278,-0.07128172,-0.09524687,0.113764614,0.03946067,0.034164242,-0.013386252,0.011638413,-0.040602125,0.03367365,-0.0008071363,-0.0280002,-0.042304825,-0.09010786,0.027531574,0.062319744,-0.006844099,0.067952536,-0.097110994,0.056846026,0.00034525123,-0.05162768,-0.028568635,0.08733033,-0.047639705,0.0014251119,0.10017605,-0.00224969,0.042599805,-0.029133154,0.023790827,0.052553598,-0.009126576,-0.024371564,0.01659708,0.010252463,0.009482596,0.057082217,0.0130552305,0.09389849,0.016087594,0.034216598,-0.1182526,-0.027763803,0.040401876,-0.0497538,-0.00046755563,-0.0153264245,0.02385391,0.006553861,0.05478175,-0.02984193,0.027219761,0.03673981,0.044722646,-0.03789306,0.008194701,-0.05163499,0.013036406,0.02575731,-0.0001483485,0.0013162022,0.041523885,-0.09730131,0.013499855,0.0037914864,0.022419471,-0.056772005,-0.012571375,-0.021381091,0.034676943,-4.9675716e-34,0.09300021,-0.12046275,0.00046066602,0.00094291125,-0.080687486,0.08718474,-0.024994278,-0.04459458,0.0126061905,0.021026528,0.14485495,-0.013081497,-0.047691185,-0.05332429,0.034326423,0.054846253,0.07944852,0.0064360322,0.01161939,0.05012183,-0.012236765,-0.0011039798,0.022484586,0.023809807,0.05051677,-0.054726243,-0.059672907,-0.02912305,-0.0535123,0.05019255,-0.0059966636,-0.0030657116,-0.06274621,-0.07105451,-0.028696435,0.07269083,-0.04075959,0.034736406,-0.07336415,-0.058950674,-0.056937814,-0.0044701444,0.061799653,-0.014942683,0.030709054,-0.041108686,0.027508132,-0.08140888,-0.053959865,0.003187686,0.038224325,0.007070087,-0.039301865,0.024751931,0.033336215,0.07907989,-0.035832204,-0.06022888,0.031423867,-0.06132682,0.0041171964,-0.034502875,-0.042148553,-0.07175885,0.15650524,0.035759084,-0.06370672,0.012023776,0.115862265,-0.055216208,0.08892589,0.04256735,0.10902066,0.061426472,-0.0163255,-0.08964689,0.035048082,-0.095550254,-0.12210674,-0.02404205,-0.0876486,0.016457079,-0.055107057,-0.06998044,-0.18766226,0.025709406,-0.01267758,-0.0031626904,-0.008728444,0.10582378,-0.022120511,0.023821445,0.037663873,0.05197162,0.043032233,-2.215471e-08,0.049916647,-0.02199129,0.10291018,0.01733449,0.026475267,0.005603953,0.05581862,-0.025914924,0.02801475,-0.008343313,-0.021906791,0.12533285,0.12387613,0.006570426,0.037613608,-0.0062382,0.024362009,-0.025330829,-0.020895977,-0.07391378,-0.05323628,-0.021610424,0.034777023,0.0109935,-0.01179486,-0.026934745,0.024848605,0.08155996,-0.03446611,0.0012823687,0.007660377,-0.026674174,-0.049836043,-0.010269853,0.016319681,0.0263321,0.07947749,-0.0029158518,-0.07911448,0.0783858,-0.020490903,-1.811296e-05,-0.05855529,0.04570435,0.052769948,-0.05437002,0.05157077,0.040038075,-0.0025083658,-0.056373976,0.034402184,0.023321128,-0.085812576,-0.014041239,-0.00952907,0.0026485363,-0.017020656,-0.01228275,-0.03514243,0.00050882186,-0.03285934,0.006293997,0.08395664,0.006266041 +2.3.1.7,Also acts on propanoyl-CoA and butanoyl-CoA (cf. EC 2.3.1.21 carnitine O-palmitoyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase).,384,1.0,-0.13322125,-0.041226484,-0.081569575,0.011845273,0.050886806,0.021357248,-0.13276017,0.019551028,0.03721924,-0.0355457,0.055589125,-0.08543537,-0.15410003,0.0316507,-0.009419901,0.03882843,-0.05958323,0.07528641,0.032282334,0.044640563,0.062993094,0.048193544,0.023681685,0.057588965,0.049262173,0.021526283,-0.021872452,0.04388819,0.0799581,-0.08304386,-0.018907655,-0.054864492,0.0658631,-0.032554284,0.10672207,-0.024690732,-0.022281699,-0.06485926,-0.03211234,0.027722482,0.059456166,-0.09275673,-0.019575864,-0.0010027563,0.03321623,-0.06172488,0.00728455,0.043940775,0.0050103567,-0.0027894282,0.0042871446,-0.052766133,-0.11034563,0.03497315,0.014770631,-0.033156753,-0.057175208,0.0032124096,0.047940217,0.1096266,0.013104366,0.021749977,-0.040030573,-0.011725541,0.036001425,-0.00559168,0.076687686,-0.020676957,0.056183003,-0.039304074,-0.032519292,-0.06884877,0.04584154,0.097089335,-0.02818889,0.03203527,0.004566837,0.044839595,0.021458443,-0.08511569,0.04477176,-0.04357475,-0.030679034,0.0151115125,0.009555042,-0.020535251,-0.08860495,0.035962798,-0.025060814,0.0435068,0.036428723,-0.04654198,0.025518404,-0.026364973,-0.020435663,0.035688795,0.07785517,0.032408856,0.058972746,-0.041695267,-0.03388108,0.08918755,-0.10754467,-0.057274804,-0.02863336,0.030341735,-0.012324855,0.021852508,0.016734095,0.01133938,0.015148594,-0.032741208,0.0026253706,-0.046401527,-0.090135,0.04697477,-0.06295888,-0.033035673,0.023135886,0.064255744,-0.05652333,-0.031828675,0.007483009,0.10129755,0.013621978,0.022235092,-0.034286983,1.9666239e-33,0.060688883,0.014704979,0.019326331,0.03956233,0.009937345,-0.061860517,-0.07067494,-0.00934597,-0.061370097,-0.084922515,-0.025371263,-0.06134848,0.045491807,0.07151097,0.015014663,0.0068564736,0.016247088,-0.07963822,-0.00011199311,-0.024635708,0.027308658,0.028884264,-0.05339002,0.07147519,0.021223312,0.023575703,-0.084544644,0.034038782,0.070877716,-0.0027756968,-0.00035825933,-0.092852965,-0.02808642,0.014935713,0.06500683,0.0029633492,-0.039344978,-0.0985805,-0.044374023,0.107767,-0.0007689741,0.014054761,-0.11468167,-0.029884849,0.049528703,-0.056434594,0.017259635,0.059184425,0.07375223,-0.012674746,0.03761268,-0.044530485,0.017256286,-0.009186694,-0.05538208,0.07331154,-0.08072787,-0.012448542,0.012216854,-0.011569272,0.028429518,0.024073415,0.025263844,0.008337879,-0.011869923,0.06601265,-0.15827325,-0.04342666,0.012062895,0.017394654,-0.053234406,-0.009607844,0.10576997,-0.027676962,0.09955901,0.049556226,-0.064134054,0.08262456,0.011360384,-0.023090893,0.014833899,-0.032814257,0.075731255,-0.0196409,-0.04213591,0.043857075,-0.02056953,-0.097377166,0.0148096625,0.091341,0.016449085,-0.071510196,-0.016371297,-0.059456464,0.026321758,-3.0299827e-33,0.07708769,-0.02490113,-0.022369727,-0.05905141,-0.069302306,0.10701965,-0.0656585,-0.070013754,0.03117678,-0.023743693,0.066784374,-0.031099547,0.08347178,-0.10536869,0.049450494,0.028809963,-0.014835264,0.08697679,-0.032608416,0.024021093,0.010744332,-0.009459994,0.025007734,0.071487695,0.080262765,-0.014489371,-0.041621447,-0.015282319,0.09738679,0.038339794,-0.004486888,0.023686549,-0.050283,-0.016891718,-0.024630168,0.008769884,0.008426329,0.05359826,-0.048258707,0.012412084,-0.038377617,-0.013535058,0.024144877,0.011540208,0.024554435,0.025577622,0.04096353,0.024286551,-0.046085104,-0.06609115,0.06163919,0.005146462,-0.06119186,0.053914327,0.04666347,0.05281533,0.04492282,-0.036840055,0.011307209,-0.047111854,0.020562885,-0.060298473,-0.014446695,-0.0820764,0.09940715,0.012773016,-0.040958043,0.03125386,0.037543416,-0.008990142,0.047314044,-0.058891058,0.021637924,0.039607283,-0.038297303,0.0017487751,-0.014752321,-0.1010658,-0.021447377,-0.062908396,-0.0400158,-0.043716367,0.015152392,0.019747455,-0.036913004,0.06901175,0.010244358,0.07981389,0.033918824,0.07311857,-0.059838835,-0.0012966733,-0.050466232,0.079959914,0.014068825,-3.6170842e-08,0.10565219,-0.061055284,0.014258638,0.0072726035,0.012063297,0.03542931,0.014605661,0.026018808,-0.012304965,0.00081126834,-0.0007274072,0.028206812,0.0673924,-0.08591784,0.0330511,-0.025768414,0.08835314,0.048373364,-0.024957433,0.010932479,-0.083166525,-0.022505876,-0.012694655,0.015292724,-0.025843874,-0.0679145,0.046132114,0.09513333,0.058842275,-0.047336865,0.026971806,-0.023892188,-0.000689745,-0.059479266,-0.02340826,0.01142627,0.059090503,-0.03798102,-0.04856652,0.08721831,0.016488427,-0.03157217,-0.05662547,0.07060689,0.05259077,0.022679212,0.0026731328,0.029845096,-0.047566194,-0.0136044435,0.024612619,-0.032148194,-0.07664913,-0.030569421,-0.059241768,0.018733557,-0.017174456,-0.035775926,0.012155725,-0.05730017,0.025424045,0.0015527318,0.14434655,-0.011235704 +2.3.1.8,Also acts with other short-chain acyl-CoAs.,384,1.0,-0.09586904,-0.0804335,-0.014499351,0.05488784,0.026437003,0.00833344,-0.063653834,0.05946594,0.048840802,-0.034368515,0.103565075,-0.011556769,-0.017875994,0.08777378,0.016735012,0.035929605,-0.04924145,-0.0020028288,0.020974908,-0.07257217,-0.025876684,0.07052543,-0.015162115,0.0014625317,-0.036137793,-0.059166428,-0.0046060733,-0.0067597646,0.0191595,-0.098796554,-0.02588703,0.032318313,-0.02484924,0.019117361,-0.000985199,0.028813267,0.005238542,-0.0074069463,0.05931114,0.03969543,0.06929533,-0.05844207,0.02810103,-0.011075883,-0.07341453,-0.055395532,-0.040444594,0.030590195,0.04250088,0.063621804,-0.03502448,-0.018078173,-0.0554323,0.11625749,-0.02256314,0.054134596,-0.12053305,-0.053386625,0.006443547,-0.00044618754,-0.017099665,-0.016550051,-0.063356794,0.0814043,-0.0139686065,-0.009098622,0.034698457,0.02685889,0.0046498864,0.015769916,0.0024699785,-0.06414735,-0.04176817,0.05969289,0.055672184,0.009593543,-0.014838127,-0.12959522,0.025726447,0.040671512,-0.10185445,0.098418675,0.033813696,0.043119412,0.035665832,-0.02925199,-0.0036453463,-0.084774025,-0.13351394,-0.015307901,0.02756982,-0.06954672,0.011681003,0.0018325194,-0.035344087,0.013142675,0.06223105,-0.013632812,-0.086908855,-0.018086426,-0.04545239,0.048639365,0.005088178,-0.033876825,-0.032505576,-0.02163701,-0.013393137,0.02087466,0.001613067,0.0009943179,-0.0207892,-0.016907373,0.04049203,-0.021406442,-0.021372624,0.05137571,-0.03202746,0.03445682,-0.010314612,0.036338322,-0.0065946165,-0.007906773,-0.05069847,0.060306653,0.022863973,0.031170908,-0.058451526,-2.3860265e-33,0.043798983,0.00013896127,0.027740667,0.0031626474,0.036282964,-0.030691141,-0.10256228,0.012971366,-0.025943156,0.04566273,0.008875313,-0.016447235,0.029699797,0.08557859,-0.044584006,-0.07061004,-0.01332138,0.021401351,0.02226109,0.0065508094,-0.034142237,0.11802033,0.045806874,0.008640254,0.02649893,-0.028006762,-0.038430795,0.046848495,-0.010942816,0.020238686,0.00022424558,0.016648931,-0.03986292,0.06438816,-0.012026421,0.06548187,-0.060813703,-0.05886459,-0.050276868,0.07464632,0.057288453,0.050176274,-0.11480536,-0.020817656,0.036625177,-0.10833656,-0.07324938,0.057947922,-0.0067044557,0.057951987,0.12032407,0.009545634,0.07807366,0.03451729,-0.018062139,0.05380622,-0.05137225,-0.04611105,-0.00880141,0.0021211489,0.035875726,0.079996675,-0.047430918,0.038381092,-0.005918486,0.019751335,-0.080971114,-0.036077604,-0.04127669,0.012503218,-0.025866928,-0.007946981,0.046670187,0.029155407,0.03703013,-0.0127768675,-0.05479012,0.022871604,0.07067626,-0.0029364799,-0.021981275,-0.080824435,0.108580835,0.031069698,-0.0111518055,-0.049921606,-0.0071933228,-0.048113614,0.025811216,-0.02658542,0.06519984,0.000585933,-0.008256953,0.020591155,0.06078656,4.4271937e-34,0.09317905,-0.122980215,0.03202552,-0.07884225,-0.053539377,0.034357708,0.02368515,0.022566278,0.038413003,-0.00088847935,0.11004859,0.063654035,-0.095875554,-0.047186654,0.10185717,0.047624797,0.08361883,0.0126449885,0.007941114,-0.00078114035,-0.031927366,0.04554524,0.058448907,0.013380223,0.05212201,0.030014975,-0.03291271,-0.014582763,-0.030033195,0.03785815,-0.0024497379,-0.0031459937,-0.05848601,-0.062834926,-0.056329627,0.018411634,-0.08586287,0.03915711,-0.00969823,-0.07745934,0.027910508,-0.017147135,0.08483608,0.051577564,0.02238423,-0.0039022102,0.014705821,-0.06747418,-0.076567166,-0.06409882,-0.05711839,-0.0006786125,-0.032120515,-0.0070736078,0.02289987,0.08225042,0.011266819,-0.063092925,0.0448817,-0.11065777,-0.039938923,0.026669944,-0.047889408,-0.05637038,0.100943156,-0.0016784564,-0.04419404,-0.025757732,0.08533134,-0.02539616,0.1324207,0.111736186,-0.020101577,-0.036871526,-0.056021176,-0.03549523,-0.026585903,-0.102829754,-0.027266147,-0.02313394,-0.10501754,-0.042068608,-0.017208904,-0.03145206,-0.10087085,-0.04266749,-0.020466149,0.03743947,0.03398015,0.07237943,-0.015457142,0.0050921245,0.0290015,0.054158602,0.033597287,-1.8649077e-08,0.052926037,-0.04430966,0.0037079668,-0.01691888,-0.0025808557,0.027490415,0.0022746683,0.015045227,0.03525737,0.00455825,-0.008859896,0.1189641,0.111895375,0.051056586,0.055150907,-0.050240103,0.008115841,-0.0050048856,-0.0388191,-0.043175437,-0.15805914,-0.002311034,0.044397775,0.12114746,-0.080121554,-0.045694306,0.04996688,0.012140431,0.008381533,-0.017059622,0.02015651,0.010292263,-0.042452242,-0.015046692,0.01560041,0.007326504,0.115363486,-0.04879897,-0.0070875003,0.044777304,0.018942125,-0.027264655,-0.018185543,0.030506473,0.05334095,-0.05633384,0.0216905,0.019230738,-0.0100941295,0.0048122415,0.044416606,0.0013630122,-0.046142258,0.0054210066,-0.068721384,-0.015427531,-0.011082151,-0.053698257,0.0027287756,-0.012872054,-0.024343073,-0.01175434,0.18557012,-0.0015889654 +2.3.1.9,"The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.",384,1.0,-0.10793816,-0.052058063,-0.09372624,0.009803558,0.12879777,0.04993349,-0.11023584,0.041481316,0.088993244,-0.042251557,0.13686363,-0.10472977,-0.079261586,0.02978459,-0.04739452,0.055284716,-0.08329428,-0.010606037,-0.017666424,-0.048374142,0.0037112902,0.010139533,-0.054000054,0.04286935,0.059698496,-0.0098977145,0.033332273,-0.032198433,0.0133895865,-0.0561014,-0.018299278,-0.025082689,0.0454848,0.006084194,0.073977835,0.029955732,-0.010532362,-0.08261123,0.056774713,0.023466444,0.04429892,-0.05476702,-0.028607987,-0.024652045,-0.035732996,-0.0033408047,0.021827113,0.054059874,0.040946,-0.022114193,0.0045336736,-0.014877544,-0.08035589,0.0073214606,-0.004302916,0.057084277,-0.049100976,-0.045373604,0.015470214,0.014865797,0.019714337,0.00996415,-0.06317819,0.05053991,-0.0066136844,-0.10163992,0.07625546,-0.04442563,-0.008903939,0.0063272403,-0.061461303,-0.065340385,-0.05483265,0.07423811,0.042697724,-0.0031601794,-0.025479479,-0.08004086,0.012345993,0.008818181,0.008867912,0.032293048,0.02977448,0.020410242,0.018548613,-0.035280026,0.06581496,-0.018348834,-0.0064121275,-0.0064115743,0.0031305677,-0.024480177,0.002315372,0.007973153,-0.057757974,0.10384871,0.09932436,0.048832703,0.06870348,0.008897674,-0.012622496,0.098675996,0.015138808,-0.08963428,-0.034834057,-0.015483369,0.004274941,0.11572665,0.02613228,0.039899874,0.02409167,-0.05033617,0.058563218,-0.05016687,0.03440138,0.1122299,-0.018594518,0.01111682,0.040569942,0.051135313,0.036723316,-0.028881356,0.027322503,0.10810714,0.018300282,0.07213348,-0.073411174,1.0024747e-33,0.067346126,0.040442854,0.01127588,0.05146895,-0.0024506995,-0.060667243,-0.10639634,0.07319386,-0.05823204,-0.01618852,-0.018613053,-0.06745664,0.029919157,0.0237812,-0.0130557995,-0.073978566,-0.008003841,-0.054835565,0.028238729,0.043766893,-0.031263307,0.041640062,0.02434461,0.044471372,0.042289644,-0.025769943,-0.013083076,0.051102173,0.05461758,0.0119865155,-0.021582684,0.0011140857,-0.090237625,0.0073834225,0.014112009,-0.018371992,-0.004140118,-0.0668798,-0.008818792,0.09008068,0.05933586,0.033266485,-0.036296032,-0.06674152,0.04590971,-0.09716865,-0.05495544,0.06807958,0.018919807,0.022068955,0.02045543,0.016583662,0.06982626,0.007819232,-0.027727902,0.031862386,-0.067893445,-0.050666563,0.019729601,-0.0064742044,0.040019777,0.07709986,-0.017194014,0.029667865,-0.059527516,0.032930855,-0.11133398,-0.058151115,0.01319671,0.008297406,-0.048001844,-0.0018499672,0.04700061,0.05041364,0.098032944,-0.05333505,-0.068130344,0.020050429,0.04749011,0.00079040683,-0.054087337,0.019482344,0.04721822,-0.0092106955,-0.038949188,-0.044282623,-0.055068225,-0.024132194,-0.005809935,0.018865567,-0.006489611,-0.034335274,-0.004665796,0.03231265,0.02639513,-3.2658524e-33,0.12137437,-0.12942664,-0.0075320643,-0.119308054,-0.07704303,0.059322383,-0.035659034,-0.040440876,0.009254902,0.012719205,0.08804915,0.007948875,0.008201377,-0.050797544,0.072136946,-0.012853088,0.019499347,0.025571223,-0.042747688,0.030453086,0.013895566,-0.011803207,0.04193771,0.004023938,0.07086892,0.0020764018,-0.032324124,0.021572364,0.03419075,0.07930867,-0.062321797,-0.038123738,-0.034676656,0.0067133442,-0.10494558,0.033375725,-0.038520474,0.039284352,-0.015779253,0.02840161,-0.008746078,0.007641471,0.00653809,0.033928875,0.0515398,0.036559753,0.016628237,-0.02187351,-0.0012725395,-0.13937865,0.02471886,0.010842968,-0.0066797957,0.0058371015,-0.05303574,0.100046836,-0.018850168,-0.012200575,0.047918532,-0.089612715,-0.068253815,-0.05337207,-0.032687206,-0.048994463,0.090856634,0.0113191875,-0.111089155,0.052267026,0.03887921,-0.032300223,0.046697266,0.019697933,0.017593376,0.004828823,0.0065385676,-0.047668185,-0.020074237,-0.09037437,-0.04196784,-0.037458207,-0.06475594,-0.035784323,-0.013822791,-0.032984935,-0.122801185,-0.05994985,0.046653807,0.010823401,-0.04605761,0.042430714,-0.056810766,0.011029199,-0.00046732332,0.061412163,0.045584098,-3.860849e-08,0.004554204,-0.0425302,0.035244603,-0.041051455,0.03831876,0.040166434,-0.0011519552,-0.0056676054,0.069937564,-0.036288697,-0.08245018,0.125426,0.07151815,0.037292983,0.0073099625,0.048417356,0.0049882806,0.020554295,0.016918946,-0.03645022,-0.06379052,-0.0050353194,-0.010926935,0.057696242,-0.06064769,-0.063458085,0.051931728,0.08737392,-0.08630575,-0.015506114,-0.04738755,0.040150043,-0.00055487454,0.0046293167,0.022189962,0.010873058,-0.011408374,-0.08490821,-0.03243954,0.029877208,0.064502135,0.03541672,-0.114671595,0.037560545,0.09672023,-0.014451829,0.036049705,0.014089519,-0.028200109,-0.039176892,0.06631009,-0.005814515,-0.04191812,-0.0057554645,-0.010675622,-0.0259837,-0.034635723,-0.09054316,-0.0076070004,-0.019435572,-0.012577304,0.04042686,0.16242094,-0.03435395 +2.3.1.11,2-Sulfanylethan-1-ol (2-mercaptoethanol) can act as a substrate [1].,384,1.0,-0.02398075,-0.039821897,-0.009433568,0.037084077,0.091790155,-0.07874216,0.032192037,0.016098218,-0.0030494807,-0.041166026,0.049127642,-0.078851566,-0.09916155,0.078938186,0.030680902,0.045058213,-0.04897115,0.0011969865,0.054112732,0.09549126,0.07274375,-0.023452835,0.019454269,0.0071760286,-0.022609554,0.06508581,0.034987845,0.074594304,0.025024476,-0.0830644,0.04210082,-0.048396472,-0.0019716052,-0.007236075,-0.015427,-0.0070953663,-0.026820604,-0.04793608,-0.07718306,-0.07480809,0.072812356,-0.010829014,-0.023261761,-0.057430368,-0.06266549,-0.08326349,0.04163458,-0.0035935033,-0.015217475,-0.0900719,-0.006598014,-0.029786061,0.011237613,-0.01131241,-0.040297747,0.035396695,-0.09366021,0.041377783,0.021701034,0.021843277,0.06777394,0.019589271,-0.021456739,-0.036469594,0.045322895,-0.0013570731,0.029973421,-0.06760519,-0.013225396,0.061295014,-0.11955199,-0.026280731,0.0021940956,0.0009575938,0.109645024,0.0602512,0.017500332,-0.034841664,0.13899535,0.024044914,-0.076580726,-0.012405321,-0.025191206,0.05154217,-0.001471915,0.003493091,0.00027188566,-0.027197221,0.019216286,-0.044245593,-0.025402108,0.08708211,-0.011347298,-0.04556631,-0.009997449,0.04240961,0.025529202,0.07605606,0.035389885,0.07942061,-0.043318264,0.04944444,-0.07608328,-0.047933657,-0.04580309,-0.015836673,0.0014594066,-0.00044728743,-0.048126128,-0.029609712,0.01182515,-0.037805557,0.027525125,-0.009504749,-0.09054405,0.05459874,0.01069802,0.010363058,-0.011786921,-0.042262234,-0.07546996,0.028368987,-0.017438639,0.014725817,-0.044700112,0.033586506,-0.024523214,-2.2332246e-33,0.062727466,0.024640387,0.04645744,-0.055538185,-0.036594328,-0.084594674,-0.039693277,0.018377496,-0.010588853,-0.05954674,-0.018201638,-0.03509965,-0.0061495802,0.079868086,0.04068866,-0.0637238,0.012480148,0.029343309,0.04475013,-0.025423642,-0.052616805,0.0046198675,-0.011331621,-0.019854082,0.042450253,-0.06479051,-0.030283872,-0.016799642,0.03603864,0.0132763125,0.041606426,0.013941548,-0.023417527,-0.012931459,0.016653446,0.0137789715,-0.13932236,-0.016069941,0.05164749,-0.027532581,0.008661894,0.030622274,0.117364116,0.009153315,-0.011259798,-0.03422347,-0.036351025,0.09396365,0.042537257,-0.017756918,-0.010080831,-0.067701854,-0.022960076,-0.07552184,0.041002605,0.010881408,0.04516265,-0.012825286,0.06574151,-0.012516983,-0.050057642,0.028736185,-0.050947376,0.024162479,0.0060588997,0.087790176,-0.03848168,0.0577418,-0.103590935,-0.08447276,0.0040788227,0.025409797,-0.025760856,0.013034972,0.0035691336,0.013540188,0.037056517,-0.05393065,0.09391185,0.03468553,-0.019982597,-0.049170602,-0.066550024,-0.07028788,-0.13653088,-0.017525261,0.014400036,-0.025935289,0.018386554,0.09692632,-0.06265669,-0.052425236,-0.04402376,-0.026908526,0.00020770374,-1.6258301e-33,0.05631305,-0.050458312,0.013098701,-0.0668351,-0.06536128,0.034823406,0.060835116,-0.016528405,-0.009160362,0.015713044,0.10450261,0.04487358,0.056883667,0.00016787824,-0.054181065,0.05424108,0.022413865,0.00018972422,0.058721203,-0.025910255,0.016508026,0.12599595,-0.015594876,0.086632304,0.031587373,-0.05908434,0.08838463,0.007791692,0.0112214945,0.07175508,-0.03680924,-0.008406323,0.08522219,-0.001296636,0.038956746,0.014819094,0.06941291,-0.078229524,-0.036428094,-0.027019568,-0.02836792,-0.012411333,0.004950094,0.10045306,-0.010490883,0.023686357,-0.026465736,-0.037360597,-0.07694702,-0.056235805,-0.033827968,0.021432424,-0.039373185,0.0017728637,0.0106515745,0.093676835,0.00586943,-0.06364119,0.0060523315,-0.059819367,0.036617294,-0.031503,0.0073019275,-0.10066288,0.018307107,0.011755673,-0.072237074,-0.02486556,-0.013816796,-0.06939328,0.10031969,-0.00149949,0.040562067,-0.051307205,-0.08794576,-0.08052901,0.035508215,-0.0033877087,-0.0708938,-0.03122377,0.04395,0.019483674,0.019599903,-0.058596503,0.06832513,-0.07630202,0.026648626,0.08599368,-0.047469012,0.07524838,-0.0012363185,-0.001935154,-0.03139222,0.1338711,0.059663355,-3.3027383e-08,-0.02126232,-0.011767517,0.094035186,-0.059079945,-0.09414942,0.059794407,0.058293793,-0.07018602,0.031987887,-0.01590215,-0.07566872,0.09006287,0.019863753,0.00023761808,0.06981195,0.035041757,-0.048712175,0.017507019,-0.02467414,-0.07146282,-0.061799254,-0.08601318,-0.049688023,-0.02518017,-0.021524452,-0.07799675,0.0051218034,0.035931043,-0.016397357,-0.051016558,0.028812326,0.033334464,0.0012553604,0.026580565,0.019754978,-0.0072302097,-0.0661436,-0.096342266,-0.069193184,0.017926428,0.05148256,0.08012614,0.0005414175,0.032936495,0.05804172,0.053775903,-0.0010926037,0.09863686,-0.06513776,0.062263537,0.036145855,-0.014022871,-0.0059115356,-0.005802257,-0.07543322,-0.0394061,-0.017335622,0.06861456,-0.032082964,-0.0044816267,0.11173473,-0.028887345,0.13495179,0.03690754 +2.3.1.12,"A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalysed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A.",384,1.0,-0.08950625,-0.020493748,-0.08250651,-0.031767763,0.086490326,0.0329539,-0.098389894,0.02105745,0.027292471,-0.04375598,0.088558905,-0.07322132,-0.105226986,-0.063261546,0.006823034,0.008434461,-0.12532598,-0.01778794,-0.029603692,-0.06810046,0.08831642,-0.017624568,-0.01293739,-0.023084484,-0.0048888777,0.024651255,-0.0058351494,0.044318076,-0.0056327297,-0.10828335,0.0077962615,-0.029780125,0.04208861,0.009366012,0.015344565,0.114718124,-0.036219086,-0.073435076,0.038187217,0.06485087,0.0603135,0.015019823,-0.038396183,-0.02820325,-0.03944637,-0.03850062,-0.025205884,0.05955711,0.0013424986,-0.0113897715,-0.008828601,-0.030944943,-0.035485633,0.049146846,-0.014635615,0.09368308,-0.020180661,0.015497216,-0.05877038,-0.013122415,0.053637285,-0.016016118,-0.0098041855,-0.0035171262,-0.03656183,-0.055721983,0.11507529,-0.094730794,0.035869025,-0.018944804,-0.102707386,-0.11049523,-0.011687374,0.006637085,0.014207176,-0.006994397,-0.066016756,-0.086959794,0.011493822,-0.024457427,0.023703165,-0.02863535,-0.040545374,-0.0102815265,0.08682015,-0.037011996,0.001617968,-0.07584497,0.05839986,0.04653499,-0.024775593,-0.06044406,-0.031560905,0.030113677,-0.031455256,0.096302934,0.08514171,0.059364434,0.036910664,-0.05488674,0.04624533,0.10606564,-0.028305825,-0.044203207,-0.030672526,0.02689949,0.032486483,0.06838912,-0.010885899,0.0017684092,-0.009645039,-0.022387054,0.11247262,0.0014125608,-0.0035843488,0.0809173,-0.044670522,-0.028799739,0.036829744,0.037641447,0.049481742,-0.01750514,0.13235365,0.091552556,-0.009524667,0.053153418,-0.13292263,3.680151e-33,0.036788903,0.040639162,-0.006043009,0.035386886,-0.032543667,-0.0042682854,-0.1563008,0.08297095,-0.07734854,0.012519816,-0.02948012,-0.06882432,0.081901744,0.038161207,-0.10834728,-0.052171826,-0.040775944,0.019866431,0.05213928,0.029205017,0.00806721,0.06438954,-0.06535233,0.0035414053,0.010254467,0.01693551,-0.012277675,0.051671162,0.06339738,0.02990837,0.019145751,-0.08462147,-0.033847876,0.014496804,-0.02303098,0.049791973,-0.03519028,-0.037936132,0.012898373,0.03262516,0.018104749,-0.013551518,0.016218029,-0.065908685,0.021802763,-0.050138015,-0.050636604,0.067119114,0.059879627,-0.01215484,-0.01621933,-0.071480654,0.11509635,-0.03990614,-0.02661836,0.033516273,-0.08141204,0.040697917,0.03004217,0.09258549,0.027854411,0.07797472,-0.04980447,0.03732235,0.024473084,0.063860774,-0.08185063,-0.05543701,0.01340398,0.06621784,-0.0641726,0.027546417,0.07686063,0.03770062,0.048571654,0.01131065,-0.045514278,0.059996113,0.038173188,0.031791814,-0.05767374,0.082016505,0.01109369,-0.0129381195,-0.062481035,-0.0009876498,-0.039491005,-0.039605323,0.05666231,0.08632512,0.002571047,-0.057824645,0.0131340325,0.0060308524,0.006822632,-4.5993354e-33,0.034400355,-0.031671584,-0.014463764,-0.057458337,-0.035926096,0.11324359,0.08461588,-0.055732675,0.026710095,0.0065159714,0.09792064,-0.021849977,-0.007510415,-0.08340644,0.06994914,0.046237063,-0.020321429,0.0132772,-0.010821591,0.0014533458,0.0039236182,0.004563155,0.04776347,0.08653129,0.029551027,0.020312274,-0.024608327,-0.006029789,0.02773467,0.048154168,-0.019130912,-0.020181078,-0.03218076,0.051305667,-0.0847059,0.058742348,-0.14783314,0.017272746,-0.007276169,0.05999125,-0.024597691,0.030992154,-0.010866043,0.02122361,0.07318094,0.046688907,-0.047090348,-0.020831792,0.008568037,-0.039035466,-0.022223402,0.002501894,-0.043417346,-0.010805759,0.025915504,0.09929404,0.025545953,0.00838993,0.01849363,-0.063307166,-0.06172948,-0.048708215,0.033632606,-0.00690125,0.031308115,0.0047107358,-0.022685884,-0.011999075,0.013040801,0.024107512,0.05601135,0.024562242,0.005102764,8.236451e-05,0.031938527,-0.06831864,-0.054366406,-0.03583027,-0.09416073,-0.0902443,-0.0383186,-0.038391043,-0.026967764,-0.07091843,-0.050137095,-0.069153,0.02258741,0.052788574,0.0025274686,0.01852502,-0.02118289,0.0007501875,-0.07357691,0.00829013,0.07937062,-4.2929905e-08,0.051295314,-0.016492503,0.054720845,-0.024661966,0.0529354,0.038949832,0.03093949,0.0003596967,0.058324307,0.009217022,-0.020749563,0.08143926,0.08156637,0.025935974,-0.008015907,0.031181987,-0.0592077,0.021718612,0.006544165,-0.057004448,-0.041669402,-0.013851379,-0.09836995,0.022014545,0.0032376794,-0.061254725,0.015190669,0.07620145,-0.06768902,-0.062853366,-0.006377127,0.048033297,-0.02364551,-0.025010306,-0.04243677,0.014654997,-0.010865638,0.033436045,-0.036989145,0.09783034,0.025553036,-0.059310563,-0.08056585,0.045961116,0.081393726,0.029644327,-0.019564992,-0.0036336489,-0.014233743,0.02619288,0.023942495,-0.006131116,0.032972034,0.018886086,-0.05325623,-0.016412962,-0.08005178,-0.07338175,0.037133925,-0.02291363,0.026263263,0.010791614,0.10091624,-0.057615396 +2.3.1.13,"The CoA derivatives of a number of aliphatic and aromatic acids, but not phenylacetyl-CoA or (indol-3-yl)acetyl-CoA, can act as donor. Not identical with EC 2.3.1.68 glutamine N-acyltransferase or EC 2.3.1.71 glycine N-benzoyltransferase.",384,1.0,-0.105983935,-0.07056404,-0.0755162,-0.061586782,0.03914885,0.04715707,-0.06809272,0.01731468,0.09348983,-0.09451995,0.0980223,-0.080989085,-0.04746821,0.013694084,0.0053512137,-0.024696367,-0.029011069,-0.0003519302,-0.06164239,-0.04142173,-0.07872563,0.05237841,0.021958534,-0.017932765,0.07034465,-0.016249727,0.020838263,-0.05001974,0.06336044,-0.090340614,0.03301686,-0.08317295,-0.06306781,-0.046145476,0.045061965,0.010312565,-0.033613652,-0.03818636,0.06979569,0.04463287,0.01872342,-0.08353871,-0.046871684,-0.041778613,-0.040883046,-0.0817924,0.04338987,-0.0059783757,0.009145024,-0.01740783,0.06522458,0.0012769921,-0.076639764,0.06545935,0.010998097,0.027529867,-0.09253203,-0.0061089504,-0.061237928,0.06580587,-0.038791444,0.039574534,-0.009747872,-0.032497585,-0.039041996,-0.005839396,0.086740226,-0.097324915,0.09693228,-0.036420804,-0.062880516,-0.06366758,-0.0046459064,0.037262972,0.037176907,0.033565015,-0.03666847,0.03374806,-0.0074440045,-0.0061066533,-0.058525417,-0.024535438,-0.038614895,0.032745104,-0.006128502,-0.008393975,-0.10673783,0.022847775,-0.039140258,0.011811048,0.005637203,-0.0076460373,0.081719324,0.0009509876,-0.05945668,0.06360376,0.05025978,0.05642891,0.04863547,0.028390633,-0.03249518,0.15887778,-0.07132872,-0.05970611,-0.044696193,-0.010033248,-0.0016862924,0.029589053,-0.0018030653,-0.060661677,-0.030115323,-0.060524024,0.06839188,-0.03046882,-0.011348279,0.030176653,-0.07478349,-0.08650679,0.010875345,0.0018804733,-0.0001627865,-0.029365554,0.0645345,0.09194661,0.02722553,0.0662827,-0.02925477,4.767499e-33,0.050544165,0.046991605,0.103261486,0.044039346,-0.030616874,-0.005790887,-0.11907277,0.022514153,-0.0128258625,-0.10241071,-0.04611479,-0.031588387,0.030302802,0.0022421894,0.023405287,0.03461451,-0.0570253,-0.034139164,0.07039723,-0.00728765,0.03712805,0.007380707,0.024382697,0.06422801,0.0146177905,-0.025651148,-0.009640222,0.09127141,0.07256739,0.021558627,-0.058092352,-0.048746128,0.0038071547,-0.012288211,-0.08444161,-0.0104060015,-0.040079586,-0.036561966,0.009682342,0.07156599,0.054304976,0.03528603,0.027395183,0.01137651,0.033452906,0.009635894,0.0013327065,0.014032517,-0.047638636,0.022291949,0.0057597565,-0.025862869,0.08630387,-0.007228277,-0.0036691765,0.02131562,-0.0677009,0.03683671,0.009891557,0.033333816,0.014335078,0.08235791,0.008550902,-0.03264248,-0.0044319658,0.036809288,-0.049748678,-0.0033167861,-0.06830583,0.026862448,0.011578428,0.0023620324,0.015167273,0.079310745,0.11824975,-0.10808412,-0.026412992,0.06465729,0.12541625,0.018691659,-0.007842714,0.07288651,0.07628097,-0.000960521,-0.0035320285,-0.03505253,-0.018356238,-0.054941446,0.044166688,0.03017693,-0.018208513,-0.01511504,-0.0053578797,-0.022430211,0.012979421,-4.5916716e-33,0.08275374,-0.07183901,-0.060907457,-0.07263766,-0.005703721,0.012527911,0.036928706,0.005685139,0.07057387,0.045208354,0.115299955,0.0029711316,0.037650786,-0.0669032,0.048034817,-0.06294441,-0.0028320642,-0.005732679,0.003146709,0.019001072,-0.013553348,0.00088706566,-0.009175192,-0.017907185,0.045701537,0.019931978,-0.101961836,0.041619472,0.040792376,0.05925721,-0.004189609,0.023360867,-0.080028206,-0.0064525176,-0.0257843,0.048765488,0.046283424,0.06659905,-0.10468133,0.0025324593,-0.055242434,0.020184223,0.08297679,0.018380316,0.04899947,0.052045066,-0.002868077,-0.033537377,-0.03865729,-0.0674618,-0.020966763,0.062027894,-0.034168765,0.020608895,0.038033303,0.09329985,0.06623838,0.013753816,0.0732875,-0.10761433,-0.07451188,-0.043576762,0.013315789,-0.061693646,0.055793762,0.026866594,-0.014667822,0.086259454,0.027355932,-0.031818233,0.07045136,-0.09661664,0.05835969,-0.01064912,-0.0112586655,-0.06867134,-0.027499495,-0.02613357,-0.068834655,-0.094477706,-0.0024206399,-0.0782622,0.010045331,-0.03265129,-0.023353484,-0.0036190066,-0.0019878394,0.021211805,-0.010316469,0.032060653,-0.049471784,0.025972083,-0.0016416381,0.075055934,0.034851674,-4.2233292e-08,0.023595948,-0.005521609,-0.011818552,0.014638103,0.04999314,0.032922775,-0.118997104,-0.0046503358,0.008452209,-0.004294426,-0.06477336,0.06494628,0.025735833,0.046193544,-0.08249009,-0.022079501,0.001218474,0.048640523,0.010774978,-0.06775062,-0.11602314,0.060323615,0.0068122107,0.01267022,0.001045933,0.0068622944,0.04239007,-0.03484074,0.019220639,-0.073068805,0.027091565,0.008978465,0.015040595,0.00063849374,0.050080903,-0.03486412,0.077487536,-0.0052102036,-0.038631205,0.08303182,0.020416817,-0.023609659,-0.08481245,0.062245194,0.13216515,0.012399157,0.022085302,0.010770973,-0.006009853,-0.0132058095,0.054944567,-0.05048233,-0.02289637,-0.070476495,-0.038563594,-0.08002198,-0.04017405,-0.029687108,0.08849167,-0.024282578,0.015350922,0.015887426,0.14625283,0.029932655 +2.3.1.15,Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of fatty acids of chain length larger than C10.,384,0.99999994,-0.07671109,-0.067352265,-0.056508314,0.035248153,0.019234283,0.06114714,-0.03220052,0.05870275,0.004002366,-0.07221787,0.095099024,-0.051465835,-0.09291228,0.0881248,0.036375284,0.06299976,-0.0006275515,0.0006557498,-0.059552033,-0.08775377,-0.048708387,-0.024533153,-0.021174561,-0.022480665,0.020180209,-0.14269891,-0.031204775,-0.049628194,-0.007040869,-0.048997406,-0.034344155,-0.07331938,-0.031984076,0.008364966,0.041627463,0.010108709,-0.03786957,-0.0622841,0.076410994,0.010121013,0.047908172,-0.028219135,-0.0023886517,0.049836703,-0.056589186,-0.045684848,-0.0008183465,0.057174742,0.023922406,0.024525005,-0.018568119,-0.0077492637,-0.045951817,0.032075807,-0.04995735,0.10298524,-0.046381824,-0.06611575,-0.047245063,-0.009738083,-0.008487464,0.0099666035,-0.012074544,0.020383714,-0.05976516,-0.09274209,0.04039224,-0.047104646,0.078622155,-0.019542295,0.018337572,-0.1340695,0.036595743,0.040674042,0.10932307,0.010968673,-0.050916433,-0.040396612,0.06549483,0.020707661,-0.005781088,-0.016544016,0.04996096,-0.005917023,0.06732234,-0.06253142,0.0073420475,0.021486213,-0.073343925,0.02203174,0.0010731221,-0.037992414,0.0012105132,-0.008393857,-0.12255971,0.011883962,0.06045411,-0.017779887,-0.023543058,-0.0034583574,0.008406362,0.0436501,0.03330052,-0.06677403,-0.08669537,0.019794546,-0.034283664,0.017327864,-0.03268037,-0.011690634,-0.041712526,-0.024566673,0.053204924,-0.017837886,0.010385378,0.07160912,-0.10878244,-0.07243102,-0.0064124316,-0.03831853,-0.029640118,-0.03657878,0.016188819,0.07560313,-0.013288175,0.03116959,-0.06899693,-6.933615e-34,0.0005696418,0.04024419,-0.027232017,-0.0017735646,0.0033767973,-0.06495211,-0.06426583,0.049805846,-0.061227303,-0.0067581716,0.000544324,-0.08410083,0.05953381,0.06353513,-0.0116734905,-0.03609637,0.015440521,0.021464135,0.0664887,0.04006611,0.0056458516,0.09984482,0.0395235,-0.025828764,0.069980204,-0.02975026,-0.04449236,0.026539044,0.02267027,0.027052524,-0.04977134,-0.027330132,-0.007792333,0.050501462,0.021700261,0.026358288,0.018194878,-0.07502271,-0.035426617,0.03434305,0.041786976,0.011591413,-0.009639405,-0.04103072,0.033799913,-0.020831903,-0.080467805,0.008290815,-0.06194636,0.050654247,0.04335727,-0.027389618,0.07107457,0.008876233,-0.04141317,0.0013940316,-0.08561368,0.014816715,0.038031112,-0.06570379,0.009167699,0.018217381,-0.017265944,-0.014497598,-0.03497698,0.005458571,-0.04122192,-0.030254917,-0.06938671,0.11368906,-0.0069142217,-0.0048816903,-0.0018060072,0.021995401,0.087917395,-0.03620249,-0.0744467,0.06797453,0.051166907,0.020922793,-0.039928265,-0.017473008,0.09066057,-0.011357332,-0.038823117,-0.09311632,-0.04124636,-0.0036997464,0.07669952,-0.05802636,0.032107748,-0.0007585762,-0.0060936986,0.052889615,0.056449343,-2.2091464e-33,0.12733425,-0.111760244,0.03720435,-0.07186699,-0.054409843,0.05997945,0.07067977,0.018827097,0.06269718,0.0014978133,0.07360316,0.026431086,0.000633459,-0.08129831,0.05451329,-0.0017300836,-0.08212299,-0.007323744,0.011393202,0.013185476,-0.05337284,-0.011690011,0.0063650687,0.05742536,0.003649172,0.040986568,-0.08349264,0.06609916,0.08976313,0.0066180886,0.011328771,-0.004912361,-0.020685084,-0.0460056,-0.020186728,0.061202813,-0.034223273,0.041414294,-0.010694605,0.075229034,0.06597342,-0.0032959192,0.027095087,0.02839723,0.047012035,0.0067254086,-0.0005992877,-0.04042806,0.06142293,-0.15040028,0.052281566,-0.010631378,0.075746715,-0.034802593,0.024218703,0.1804328,0.061098926,-0.04508268,0.03759481,-0.12042807,-0.07853596,-0.029474381,0.048101053,-0.00078575313,-0.017498644,0.0032756797,-0.031094562,-0.01134222,-0.011425349,-0.0067742406,0.04589005,0.09592629,-0.04060456,0.06241093,-0.012710508,-0.08448243,-0.024446245,-0.051517196,-0.020742586,0.0001910142,-0.014326672,-0.052094754,0.022976836,0.00015913304,0.02897958,0.0012175835,-0.015476439,0.008650629,0.03047569,0.0054845843,9.55867e-05,0.016022269,-0.017682035,0.02616686,0.047830828,-2.9055533e-08,0.04453425,0.030520635,0.039438948,-0.015076182,-0.04881009,0.025723346,-0.028442051,-0.07231148,0.016468428,0.01700887,-0.090501375,0.12218461,0.014155662,0.08469849,-0.061657827,-0.00052761764,-0.063305244,-0.012544449,0.014046014,-0.048291944,-0.12312171,0.016482454,-0.007927444,0.060306724,-0.025245871,0.021806015,0.020481788,0.04533594,-0.012985692,-0.034192506,-0.0056695733,0.023578757,-0.03689656,0.06741286,0.06821271,0.02364808,0.049899846,-0.08616143,-0.06281156,0.06266107,0.055829167,0.0074041127,-0.056750525,0.022524228,0.09472377,-0.043815833,-0.0011187006,-0.032098353,-0.037355285,0.05116648,0.06352059,0.00025987055,-0.096877754,-0.03810023,-0.01128913,-0.03847,-0.075065345,-0.047694333,0.005202633,-0.05839316,0.018149532,0.010483368,0.19830017,-0.041471664 +2.3.1.16,"The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase.",384,1.0,-0.09131409,-0.06249578,-0.11529277,0.047609538,0.12900996,0.03544056,-0.11971299,0.020778572,0.040725276,-0.062484033,0.076714724,-0.09538904,-0.07055184,0.018819164,-0.023416769,0.038486447,-0.05749583,-0.014851328,-0.021929584,-0.07734889,0.026452234,0.01572526,-0.02126988,0.016238376,0.025973681,-0.059165247,0.027681626,-0.060318816,-0.05337445,-0.08423722,-0.0010564561,-0.08681964,0.07422664,0.010230331,0.039926477,0.07846007,-0.048800748,-0.093941726,0.039463725,0.010816013,0.043834817,-0.06071071,-0.024512155,0.004552957,-0.010031864,-0.013140116,-0.014589848,0.011166101,0.05222322,-0.0042649293,-0.025901366,-0.028336283,-0.06417643,0.047086366,-0.004431789,0.0105097275,-0.004296738,-0.025382098,-0.015408099,0.05379311,0.03313755,-0.010050193,-0.04632413,0.027162477,-0.0117386365,-0.09587201,0.058043018,-0.07883919,-0.03226789,-5.131767e-05,-0.090616085,-0.07983192,-0.06475889,0.06123222,0.002187414,0.0025351618,-0.03122361,-0.08685463,0.0061609014,-0.009684822,0.026306255,0.0021932037,0.020332946,0.057642333,0.031949975,-0.025074383,0.015152801,-0.042109065,-0.022888187,0.044081144,0.014507679,0.016416647,0.011178156,0.01604015,-0.069899485,0.051472038,0.103908025,0.013219634,0.026627176,-0.00065176847,-0.012381137,0.11308208,-0.003971932,-0.08283097,-0.03803542,0.019380085,-0.016779678,0.10966376,-0.00062704535,0.07058874,0.019587183,-0.06809372,0.025363788,-0.023424026,0.039257888,0.09587632,-0.026652858,-0.02157791,-0.0029924104,0.07392571,-0.012077003,-0.031009097,0.054334585,0.055734884,-0.0079415245,0.07577938,-0.06688697,1.760893e-33,0.044096567,0.023105163,-0.03211997,0.050479792,0.022520632,-0.058212742,-0.08090014,0.021047546,-0.008986898,-0.0046035103,0.0073740436,-0.0392202,0.033388402,0.039469086,0.0050687618,-0.045350697,-0.011849667,-0.022780314,0.055007324,0.039036073,-0.05419118,-0.014980713,0.0042922897,-0.009382633,0.046319682,0.008924641,-0.033074923,0.07826502,0.016589258,0.02102396,-0.026071545,-0.028858295,-0.10248123,-0.007953314,0.0461708,-0.022997897,-0.006233364,-0.028328108,-0.024992848,0.07605911,0.07005485,0.017296711,-0.00019037988,-0.05553189,0.052987307,-0.051614214,-0.027321437,0.13223624,0.009319993,0.018718014,0.051752336,-0.028274704,0.12644827,-0.005190663,-0.0100968005,0.0320553,-0.057433475,-0.033375304,0.030001534,-0.0072797257,0.028792078,0.06549394,-0.02528865,0.053837232,-0.008619085,0.037761915,-0.12773995,-0.079622455,-0.038009554,0.03923837,-0.0067425407,0.0044996873,0.08009939,0.04641248,0.038139313,-0.017222485,-0.081911854,0.05606631,0.04908762,-0.02302697,-0.029609028,0.009448948,0.045220517,-0.0076774433,0.00048370005,0.005572889,-0.0032807072,-0.041719984,-0.0023720954,0.009284505,0.03947064,-0.04591811,0.008164352,0.021964215,0.04412004,-3.2113613e-33,0.14130725,-0.09967953,-0.0061920458,-0.14864804,-0.043902926,0.048774417,-0.031241633,0.0011419335,0.033859175,0.020235766,0.057714958,0.011585423,-0.003566409,-0.05327094,0.07658917,-0.034265652,0.0009360357,0.007990091,-0.03885268,-0.022431865,0.061809033,0.0042156535,0.017044744,0.043483388,0.05636092,0.012115064,-0.06530217,0.036893994,0.03935954,0.056792162,-0.0808006,-0.017673604,-0.026377449,0.0014292884,-0.071959145,0.060591176,-0.06156812,0.053357,0.020993175,0.058325935,0.013085099,-0.010535066,-0.019106513,0.0074485373,0.066684425,0.036708273,-0.005931678,-0.006698299,0.01676067,-0.14779267,0.014007598,-0.033383794,-0.014630734,0.042232014,0.010886925,0.14099318,-0.01546149,0.011277769,0.06550849,-0.118174866,-0.07425145,-0.023399573,0.010206038,-0.010729266,0.0603568,0.051519465,-0.04751463,0.02597046,0.008383732,0.030252738,0.04177022,0.033513594,0.033470646,-0.009838878,-0.026917674,-0.061970275,-0.045246832,-0.044785522,-0.051587198,-0.021612821,-0.034403466,-0.031245941,-0.021347689,-0.056483816,-0.08824904,-0.08357228,0.026373804,0.052950528,-0.0016141374,0.03659072,-0.03691542,0.01939591,-0.044649895,0.0404608,0.038432855,-4.041542e-08,0.0521849,-0.023161873,0.060768202,-0.04286322,0.03327158,0.055823874,0.040246915,0.024893336,0.08663876,-0.034041308,-0.093532845,0.15459198,0.07977438,0.046539165,0.0042724656,-0.000442129,-0.012728244,0.028788153,0.027169853,-0.032180585,-0.0929585,-0.040259976,0.026260039,0.06309255,-0.031814903,-0.07803358,0.054216307,0.04624861,-0.06426984,-0.010527859,-0.054476887,0.06138823,0.011464774,-0.024155423,0.0010700502,-0.002931864,0.009456743,-0.07191105,-0.046542626,0.08433376,0.015448765,0.016469616,-0.12169529,0.03160872,0.083654314,-0.00062651513,0.020196421,0.034975875,-0.021757396,-0.048160035,0.010005175,0.016885323,-0.08935023,-0.0122693395,-0.051534057,-0.032451093,-0.03239116,-0.061839238,-0.030398292,-0.01765038,0.022722831,0.046952613,0.19725077,-0.05392904 +2.3.1.18,Acts on thiogalactosides and phenylgalactoside.,384,0.99999994,-0.050453823,-0.08646585,-0.020721277,-0.004531735,0.0074471477,0.029962048,0.0304722,0.04551129,0.08675351,0.074483104,0.065245084,0.010716657,-0.07230742,0.08421953,0.051148556,0.04495045,-0.07746377,0.06128854,-0.017842002,-0.01534829,0.09493884,0.035934683,-0.010627809,0.012180277,0.027295914,0.010062384,0.03692154,0.0393527,-0.03190805,-0.046910327,-0.0373568,-0.0058126454,0.010848558,-0.020003075,0.07171766,0.078629486,-0.11898383,-0.06862175,0.06874297,-0.056800332,0.053176817,-0.057973266,-0.0034224293,-0.009943684,-0.07330564,-0.032185644,-0.024475599,0.08392893,0.05451197,0.03446909,-0.054804515,-0.07600394,0.002645724,0.076731905,-0.08257013,0.05899895,-0.113567576,0.019597149,0.028390894,-0.050650947,-0.0005861526,0.03848685,0.02651124,0.034600772,-0.07096266,0.02970339,-0.03580614,-0.01947646,0.049372494,-0.015477463,0.030094853,-0.0102805495,-0.014738322,0.030926513,0.054657526,-0.07643888,-0.00765971,-0.04653473,-0.023626959,-0.011648595,0.0384371,0.0242223,0.046964213,0.0012834521,0.036946643,-0.011928017,0.00898789,0.055881146,0.0016324538,-0.045932677,0.04852622,-0.021227568,-0.010132742,-0.030745177,0.0076663084,0.012827098,0.00092412636,-0.031635575,0.020015294,0.023524014,0.018228825,0.009672369,-0.030327335,-0.033698812,0.046363108,0.06992,0.03826496,-0.040774934,-0.057691388,0.004144245,0.053418256,-0.041414596,0.04253282,-0.028460655,-0.016262058,0.057333414,-0.020218253,-0.0017936848,-0.026727866,-0.06294822,-0.016207196,-0.08405873,-0.007596684,0.055173624,-0.061992224,0.047008015,-0.0510737,2.6949233e-33,0.10649416,-0.055551782,-0.005177454,-0.027528545,0.09152942,-0.043887515,0.014942933,-0.05617596,-0.0013177508,0.0015027749,-0.118242614,-0.08166901,-0.027900796,-0.0016799403,-0.037838873,-0.011302633,-0.07528607,0.044695076,0.07079499,0.015471339,-0.033662006,0.054737687,-0.024558008,-0.031453956,-0.055931143,0.032787014,-0.09185067,0.05577696,0.046148255,-0.02476008,0.05707503,-0.07138353,-0.032339368,0.06890252,0.002160709,0.07167521,-0.124116346,0.013894537,-0.0040001753,-0.030669907,-0.08343478,0.048947126,-0.079579994,-0.016064838,0.022209637,-0.064831816,-0.026254823,0.04457667,0.07309926,0.056746498,0.06328639,-0.060342304,0.113018334,-0.04451861,-0.02118538,-0.041665986,0.020949638,0.016933247,-0.021460535,0.03908691,0.069243744,-0.008076847,0.042154204,0.020302104,0.03302934,0.07620617,-0.04865531,-0.014855122,-0.02576252,-0.018360028,-0.03901902,-0.009432436,0.013570985,-0.06319983,0.064678885,-0.01663354,0.034295157,-0.04405704,-0.036974907,0.042558927,0.049303163,-0.12425253,0.035390675,0.039115082,-0.067755654,0.031121805,-0.026790245,-0.10394392,0.057189483,0.023084676,0.034357697,-0.041564956,-0.055309415,0.083090104,0.053994477,-3.7322482e-33,0.03647188,-0.009464315,0.031098275,-0.013589712,-0.06391384,0.048843946,-0.071939215,0.005069331,0.006292382,0.04626302,0.048454456,-0.042421576,-0.090260245,-0.05008408,0.006620522,0.03506988,0.07403659,0.054449663,-0.03337119,0.055908367,-0.11490943,0.1284717,0.008891094,0.08750983,0.051352058,0.012529195,0.044310134,-0.046619806,-0.011523531,0.024925081,0.01215918,-0.011361649,-0.068671644,-0.08092979,0.018274542,-0.007200652,-0.033981726,-0.003082859,0.02130353,-0.025724882,0.10133253,-0.03545301,0.084947325,0.0985286,0.021479879,0.025327802,-0.032571793,-0.045964085,-0.1280168,-0.059147403,-0.08629606,0.03941569,0.016903924,0.031060886,0.06467098,0.12731048,0.03378233,-0.013849329,-0.023407528,-0.09191536,-0.053033035,-0.076102875,-0.014885456,-0.06646991,0.09437149,0.02452113,-0.14191349,0.06022925,0.067183346,0.03517784,-0.0045271493,-0.023278045,-0.05768482,0.020294841,-0.018623862,-0.0595464,-0.042310234,-0.09899612,0.019460505,-0.04628501,0.015230427,-0.021624561,-0.038175035,-0.10158875,-0.03985029,-0.0036397912,-0.004175251,0.012094096,-0.044379413,0.09954588,0.06533796,0.009385212,0.015485761,0.063547894,-0.028812166,-2.1972271e-08,0.0459261,-0.0075498065,-0.021801647,-0.037094098,-0.01075317,-0.038838208,0.032600358,0.07225164,-0.017249241,0.022489354,-0.059486866,0.09679116,0.07731295,-0.029659765,0.05798716,0.06360015,-0.06513865,-0.009161245,-0.02069866,-0.04347653,-0.06900755,-0.048009686,-0.036314502,0.050822604,-0.014361053,-0.013914656,0.08288651,0.07923466,0.010283241,0.025453119,0.020154584,0.008968927,-0.06585343,-0.020958072,0.025068233,0.039870776,-0.0094297035,-0.05945858,-0.035523858,-0.027114356,-0.053895045,0.035834227,-0.045458637,0.018473653,0.002675171,0.03752196,0.02800735,0.028426936,0.03543833,-0.010505907,-0.0040298817,-0.0567933,-0.015098539,0.012257881,-0.08698767,0.02895992,0.06290422,0.033713937,0.00299256,-0.03554531,-0.007614826,0.05375033,0.13713206,-0.041482683 +2.3.1.20,Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.,384,1.0,-0.12624878,-0.07097156,-0.05158322,-0.010661175,0.05066827,0.0070843366,-0.09455465,0.06695777,0.017600207,-0.02184804,0.085834816,-0.03117941,-0.07830932,0.05458996,0.014620483,-0.0071913567,0.012864085,0.0028352223,0.0038495061,0.0024710868,0.0023071954,0.029817095,0.003796913,-0.015292353,-0.01907046,-0.0244662,-0.024562292,-0.07358172,0.030330744,-0.07361124,-0.006047873,0.03017992,-0.009973376,-0.009927837,0.031589113,0.003606745,-0.0204604,0.011751622,0.004970765,0.013643478,0.0705125,-0.12162899,0.09102046,0.03036933,-0.099983685,-0.11154652,-0.005011653,0.05963552,0.05782513,0.06122506,0.0076475358,-0.009439722,-0.055245556,0.06906812,-0.009009723,0.061250582,-0.055059105,-0.043467388,-0.027474565,0.020678828,0.023604043,0.017471835,-0.060338747,0.041374575,0.00527734,-0.02666279,0.09882236,0.040878486,0.05815212,-0.0058117392,0.032431398,-0.08159887,0.04747532,0.070756316,0.07579273,0.06886494,0.008741229,-0.050341845,0.028931124,0.05043167,-0.06337085,0.06631424,0.05267578,0.034755234,0.030337296,0.012012805,-0.03972917,0.0062187905,-0.08142935,-0.014803889,0.006427633,-0.04301553,0.050297022,-0.041839663,-0.12605901,0.075255096,0.03269619,-0.014971465,-0.02622887,-0.0034022436,-0.039092015,0.086929314,0.0020828089,-0.08935204,-0.049435385,-0.033168387,-0.066886276,-0.01857547,0.0495746,0.010938764,-0.00629155,0.045327336,0.01461248,-0.026965141,-0.037259746,0.016954584,-0.06856484,-0.032815877,-0.013764975,0.0310956,-0.019552654,-0.021593338,-0.028046818,0.012297055,0.034016233,0.013723431,-0.023200223,-1.7155644e-33,0.005079668,0.021028128,0.07543133,0.034970574,-0.016559174,-0.057304054,-0.028888678,-0.0370869,-0.08334499,0.03502208,0.015247215,-0.050781306,0.034550223,0.10012314,-0.032118563,-0.019962229,-0.04984463,-0.044678044,0.039110463,-0.0012913169,0.024204502,0.07546445,0.05288202,0.049136277,0.08250066,-0.020993117,-0.032585733,0.09270831,0.056194764,0.02635281,-0.008803438,0.026751587,-0.011601522,-0.012127081,-0.072644025,-0.0016568614,-0.027585007,-0.08003414,-0.040645756,0.035280123,0.07278971,0.043616947,-0.07379698,-0.005001147,0.05475657,-0.09023709,-0.03973592,-0.03834229,-0.07534375,0.070819296,0.05384743,-0.04023069,0.02657407,0.05225917,-0.05035259,0.009277414,-0.05953228,-0.028557738,0.0008334631,-0.055486917,0.048589323,0.021687044,-0.01433844,0.04976205,-0.059895325,0.041181672,-0.056771185,-0.041906875,-0.046752967,0.0063010175,0.0041999877,-0.061367225,-0.028150078,0.037613057,0.050636236,-0.025303245,-0.0020276716,0.10807489,0.09140506,0.017201712,0.042574614,-0.032171205,0.10471153,0.06648557,0.0065088253,-0.03925053,-0.08567697,-0.060007386,0.05971852,-0.060439084,0.037381295,-0.016430924,0.03542082,-0.045908507,0.016710343,-5.9608014e-34,0.107484914,-0.09092682,0.0383222,-0.09986109,-0.021027695,0.023106672,0.0005986558,-0.01834773,0.069793716,-0.019334793,0.057833176,0.045019396,0.006767931,-0.061029512,0.05288343,0.030527411,0.021187104,-0.044100508,-0.018972952,-0.0026181166,-0.03131202,0.048158433,0.11086566,-0.011656445,0.027636321,-0.018532386,-0.025480589,0.00033578632,0.008764145,0.030310892,0.052208204,-0.011155067,-0.05403644,-0.036805805,-0.06188805,-0.0029938214,-0.047546636,0.04309458,-0.016663678,-0.01170097,-0.006620633,-0.023041422,0.06566639,-0.0071466067,-0.009516718,-0.07140837,-0.021532638,-0.086318165,0.040159978,-0.09009311,-0.029090716,0.02229922,-0.02081919,-0.0011730111,0.01249208,0.06711531,0.039520193,-0.071953595,0.10696301,-0.13143477,-0.07397726,0.043066513,-0.017523343,-0.021899575,0.10209263,0.019539112,0.024541285,0.020149585,0.0059127654,-0.010775277,0.088839926,0.06832041,0.022096084,0.0224826,0.007837619,-0.05008614,-0.07035336,-0.05892804,-0.04357488,-0.04518898,-0.06067307,-0.09826283,-0.047958773,0.025934106,-0.0049174125,-0.060882114,0.05966721,0.018151307,0.023124546,0.054317273,-0.051529694,-0.022550499,0.03697455,0.06756131,0.08111726,-2.4842578e-08,0.09683368,-0.012359919,-0.056429923,-0.009891762,-0.032455355,0.030611986,-0.07598489,0.0052947556,0.056703128,0.05422135,-0.029689413,0.15207563,0.061549067,0.06812564,-0.0074037164,-0.037123352,0.0041523795,-0.047762133,-0.039984494,-0.0790407,-0.13377342,0.014954268,0.06026767,0.09298614,-0.05836512,0.03828979,0.06873233,-0.007196136,0.014924027,-0.0061182124,-0.03857167,0.023916816,-0.071342155,0.056232464,0.037188288,0.0087807225,0.08888369,-0.05787036,-0.021052338,0.09346871,0.023809297,-0.013009061,-0.08275051,0.05106281,0.023899479,-0.033604,-0.016713612,0.063502654,-0.05368583,0.009971163,0.015789201,-0.008683971,-0.114901595,-0.0465136,-0.057773087,-0.006274245,-0.007733828,-0.02005057,0.0803433,-0.04598268,0.006449739,-0.053508017,0.12136742,-0.033327326 +2.3.1.21,"Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.",384,0.99999994,-0.102104604,-0.05250165,-0.11380322,0.04363088,-0.030729884,0.036499433,-0.095616885,0.053877097,0.02205129,-0.06962068,0.047911283,-0.08340058,-0.12271636,0.0038337212,-0.054578867,0.038451687,-0.04131741,0.041139282,-0.038597148,-0.014096849,0.024808846,0.030783854,0.04602396,0.006687018,0.048180427,-0.060208477,-0.0633778,-0.010307159,0.0023747934,-0.08601251,-0.014927052,-0.036037836,0.08151061,-0.038615476,0.09148706,-0.0028820643,0.001511829,-0.034308624,0.055443272,0.030269008,0.027985312,-0.036471374,-0.011469741,0.01083815,0.024562113,-0.060546596,0.006318075,0.03149558,0.012765323,0.019692605,-0.015680147,-0.025381835,-0.113806024,0.0675789,-0.011460321,-0.0008857804,-0.028174968,-0.052698094,0.015689833,0.08435351,0.034913678,-0.018407091,-0.024875022,-0.012425597,-0.019754108,-0.050784867,0.094090655,-0.05488371,0.052992135,0.012575606,-0.057770215,-0.07064017,-0.0050249496,0.06821686,0.01950773,-0.024034772,-0.01670127,0.020150002,0.03467108,-0.04921112,0.080081105,-0.012851081,-0.0048426404,0.04117076,0.062219024,-0.058505125,-0.058630805,0.0368398,0.020722518,0.08473244,0.001064325,0.016281022,-0.0047368207,-0.052990165,-0.022086088,0.02342713,0.13200074,-0.02780854,0.0076835197,-0.017079974,0.04022683,0.048348293,-0.04694466,-0.024213197,-0.056828562,-0.018295905,0.011483397,0.034305345,-0.0139806755,-0.0018522997,0.018593058,-0.013016196,-0.028011225,-0.09529067,-0.06483807,0.05267252,-0.09150173,-0.026866367,0.058807995,0.0347919,-0.08337575,-0.016627267,0.036298145,0.10131776,0.040629018,0.048450153,-0.03769328,2.737901e-33,0.030342918,0.061381362,0.007712302,0.03557341,0.008485547,-0.071932025,-0.099016376,0.014755906,-0.00530404,-0.030137371,-0.020224418,-0.07669904,0.039269567,0.061971355,0.109359585,0.04082088,-0.018791609,-0.07960196,-0.0015000992,-0.041218538,0.042488556,0.0048860293,-0.0061498624,0.08022309,0.03758688,0.02005004,-0.040147137,0.04196689,-0.009553739,0.0038721955,-0.037787173,-0.025199017,0.005849825,0.010946628,0.060108546,-0.0017170482,-0.005555795,-0.08862051,0.0059849154,0.08470943,0.039822098,0.08155955,-0.02532772,-0.069939375,0.07190506,-0.017807877,-0.035925988,0.06370484,-0.0030001886,0.07287085,-0.01088828,-0.017621808,0.050315104,0.06794989,-0.082551554,0.04316908,-0.108728714,0.021980911,0.038021386,-0.032581866,0.06488239,0.020130754,0.04982616,-0.032499988,-0.03529452,0.077984676,-0.13590282,-0.040359356,0.0047102734,0.034896746,-0.027312126,-0.06564524,0.07219626,0.004476964,0.14454006,0.059723966,-0.029532442,0.10270649,0.009308958,-0.034462295,0.036068834,0.02328423,0.08419206,-0.045790598,-0.037243355,-0.012793407,-0.02185679,-0.027452681,0.027561901,0.05671251,-0.03712822,-0.00075558416,0.012944915,-0.0154389,0.0062842425,-2.8361204e-33,0.14912337,-0.042700436,0.032319363,-0.07560724,-0.042715203,0.0947973,-0.09269885,-0.0454318,0.06180567,0.0003160443,0.034971982,0.046683885,0.096550584,-0.09643352,0.07433004,-0.035437647,-0.032627493,0.07764903,0.014071939,0.05346445,-0.0071232696,-0.055936277,0.017491955,0.070717335,0.08886762,-0.016693966,-0.110510096,-0.0032612886,0.122475855,-0.0065806448,0.0008653112,0.0019157918,-0.008865668,0.011582504,-0.0838512,0.033188,-0.042221274,0.08965832,-0.04681208,0.16434883,0.008836232,-0.030274648,-0.0019674283,-0.0009782873,0.02998152,-0.0064177187,0.019875547,-0.018568391,-0.050600044,-0.06514742,0.09200624,0.0028698256,-0.049653,-0.015498125,0.07800295,0.086868644,0.058027666,-0.06867756,0.023438424,-0.10947284,-0.011926452,0.019365255,-0.006227659,-0.049228318,0.04752538,0.024448205,-0.033514936,0.055240143,-0.009525304,-0.0057041952,-0.007592726,-0.03250684,0.026884679,0.018953605,0.0036686333,-0.0016030445,-0.026588103,-0.12318054,-0.01229274,-0.061763104,-0.07559296,-0.059771705,0.024991449,0.0030101084,-0.065878905,0.07911112,-0.0117328,0.030559093,0.05431108,0.044399258,-0.033862274,-0.043328192,-0.02285994,0.032450106,-0.008838388,-3.7154507e-08,0.12787199,0.00014906112,0.0244224,0.019044882,-0.0068979943,0.041298576,-0.041670468,0.029497376,0.0068674064,-0.0040683975,-0.0017212089,0.04241152,0.06982529,-0.0101101585,-0.056434944,0.010088283,0.028784042,0.017465727,0.0027891258,0.047409203,-0.07426373,-0.0012591514,0.0046745986,0.020407345,-0.021984736,-0.087109625,0.014936509,0.057759643,0.0005827468,-0.07531921,0.016502343,-0.0041219774,0.004557209,0.004509014,-0.040611554,-0.023036452,0.014164559,-0.053231414,-0.057950463,0.05491641,0.049131695,-0.037363622,-0.06118411,0.066408195,0.026482256,-0.0045179073,0.015480934,-0.025901971,-0.048175342,0.014978262,0.036418423,0.010859738,-0.08498308,-0.042168897,-0.008792752,-0.00018784268,-0.050135758,-0.06106651,-0.035191115,-0.09268268,0.0042520906,-0.006927142,0.07077412,-0.044256352 +2.3.1.22,"Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate.",384,0.99999994,-0.12514749,-0.15578808,-0.08044546,-0.013978597,0.034145005,0.026957715,-0.025146713,0.03282492,0.04011873,-0.06967971,0.11740048,-0.013160688,-0.0961136,0.037868727,0.030536884,-0.0007419419,-0.023156801,-0.01939686,0.03444929,-0.015941415,0.010319171,0.00015405522,0.017653843,0.011299147,0.015057555,-0.05777217,-0.033617165,-0.04241562,0.0059445603,-0.08567636,0.052322514,-0.053683367,-0.03962827,0.019140476,0.011223545,-0.04289036,-0.009175528,0.02172417,-0.018136563,0.03852514,0.07091796,-0.10882408,0.037152547,-0.0149851525,-0.016261613,-0.08826639,-0.02419277,0.039869037,-0.014296,0.05005867,0.029814918,-0.038591564,-0.064056344,0.021048421,0.011082011,0.09453204,-0.123145804,-0.0056365486,-0.03366686,-0.003035862,0.049401335,0.009799777,-0.0669499,0.022852851,0.013967698,-0.06136797,0.09970325,-0.06287936,0.059241075,0.030299038,-0.022508908,-0.07599215,0.035030637,0.0056520123,0.07614807,-0.0131274965,-0.011036016,-0.011375449,0.044990916,0.007111993,-0.026033893,0.0038277307,0.051369086,0.052364703,-0.027250117,-0.02601297,-0.06751575,0.05585465,-0.033315644,0.01557069,0.010151178,-0.031745445,0.07468917,-0.019149479,-0.046059445,0.045528144,0.064792804,0.005929361,0.039113246,0.026347311,-0.02086169,0.051720496,-0.010366803,-0.07554858,-0.013342616,0.042571805,-0.10052943,-0.02696082,0.03512667,0.015322472,-0.0032327038,-0.023272784,0.09149866,-0.026320258,-0.07392266,0.031130685,-0.07692357,-0.038111232,0.034454487,-0.009125136,-0.071393706,-0.030010078,-0.013068021,0.011831771,0.03789741,0.064707376,-0.0667199,5.331237e-34,0.027592972,0.012712888,0.012390705,0.023051618,-0.017409364,-0.04439539,-0.0403746,0.021161517,-0.09346441,-0.011011483,-0.035144676,-0.04271518,0.028825317,0.12071072,-0.04711954,-0.04507831,0.014373142,0.020801427,0.058996543,-0.043260954,-0.0028196345,0.08083823,-0.011520205,-0.02180102,0.04009692,-0.031319294,-0.0048976163,0.100973584,0.024202766,-0.007899829,0.024521144,-0.013828482,0.013802923,0.033895843,0.05328737,-0.0074420543,0.022913639,-0.0060016667,-0.0034939311,-0.00949685,0.054634053,0.05721818,-0.040148474,-0.0050488072,0.066524245,-0.036097772,-0.0958042,0.004763224,-0.035456177,0.029176326,0.042540766,-0.01675961,0.058518462,0.08118257,-0.0018932765,0.019352008,-0.018278316,0.055867787,-0.01198024,-0.09655515,0.0009461989,0.056054957,-0.024026224,-0.062568896,-0.05692525,0.058428492,-0.046984717,-0.0264863,-0.031100847,-0.018486053,-0.004883137,0.022400022,0.00051502336,0.08350325,0.09446409,-0.012181552,-0.0037489587,0.09960256,0.02130475,0.033691682,-0.056985337,0.02171853,0.052932747,0.046417896,-0.08187595,-0.07760783,-0.027207267,-0.111530446,0.071462035,-0.036159497,-0.032077678,-0.032306362,0.009509923,0.02190113,0.09767221,-1.7813013e-33,0.059432175,-0.05566248,0.06147412,-0.03400788,-0.037033893,0.07232483,0.04656771,-0.034782223,0.09847358,0.001298413,0.087631784,0.056082573,0.019460794,-0.10626009,0.08836616,0.030312557,-0.03657271,0.014169715,-0.011650568,0.009128062,-0.024586627,0.06777886,0.02177843,0.08819927,0.0033718408,0.028230608,-0.014049501,0.021779295,0.04339247,0.077351265,0.0089314105,-0.06348901,-0.030180996,-0.05955196,-0.07617638,-0.034143206,-0.08533382,0.09379317,-0.051417686,0.011607534,0.051931057,-0.038771294,0.06839074,0.06428377,0.040197726,-0.015347418,-0.01632452,-0.056374103,0.0009627637,-0.121836185,-0.0672186,0.015602002,-0.025437681,0.038658522,0.11183543,0.1378693,0.10538644,-0.052449256,0.04841405,-0.107006505,-0.07606535,-0.003913868,0.049686983,-0.007102468,0.056999534,0.024980076,-0.036114562,-0.020557975,0.05988296,-0.07016453,0.07783631,0.06693058,0.055208016,0.040988162,0.040833388,-0.05637965,-0.05500799,-0.048356768,-0.07372711,-0.057377793,-0.03146136,-0.03255526,-0.010974084,-0.026714336,-0.025872461,0.009463989,0.08948385,-0.03281808,-0.0004647961,-0.006523451,0.02918482,0.044807173,0.008809885,0.0027270128,0.03692366,-3.5953576e-08,0.044605292,-0.040331922,0.028060582,-0.050723944,-0.12268813,0.055283714,0.008430832,0.04300268,-0.017479481,-0.050051227,-0.030239984,0.103462175,0.042003494,-0.010961549,0.053984378,-0.05096255,-0.008651352,-0.0041433745,-0.07222397,-0.07443978,-0.11662553,0.021544859,0.07337608,0.033231247,-0.053373076,0.013770923,0.0024470843,0.025899442,0.00055817084,0.02032993,-0.017259479,-0.012560587,-0.04190587,0.054502763,0.038631253,0.0040587466,0.019641064,-0.05232965,-0.036281258,0.114597835,0.04351322,-0.043672897,-0.071611926,0.05487772,0.024419628,-0.057708755,0.03157775,0.014522108,-0.03884007,0.018714784,0.00962042,-0.012227557,-0.09719254,-0.077804066,-0.06414435,-0.05414924,-0.036024205,-0.012998073,0.012370846,0.012733622,0.010977856,-0.029934932,0.11726731,-0.00062944315 +2.3.1.23,Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.,384,1.0,-0.08565337,-0.11331104,-0.030000873,0.046430063,0.001697417,0.04539472,0.031129474,0.024117881,0.04207885,-0.0077678203,0.10444051,0.018939717,-0.073531695,0.13004203,0.004018565,0.021576548,-0.016268954,0.017167123,-0.024274694,-0.01167783,0.00025028415,0.025162814,-0.012320604,0.057374284,0.035175577,-0.07411562,-0.00040650967,-0.0026551967,-0.015053317,-0.09046333,-0.0344872,-0.0078431675,0.010374195,-0.0058396654,-0.013644995,0.05084658,-0.0757027,-0.04145801,0.013714231,-0.019830035,0.07260082,-0.09617649,0.007954112,-0.010111435,-0.03426004,-0.0376217,0.0035205146,0.042587325,0.020750294,0.03299676,0.025712393,-0.014601021,-0.07842066,0.057317946,-0.074822776,0.08993785,-0.16567953,0.03671322,0.0073595587,-0.059591483,-0.026642917,-0.032844774,-0.016402196,0.07178804,-0.06069063,9.6509844e-05,0.06485273,-0.05732965,0.014848214,0.09908583,0.022510791,-0.03937933,0.0075481567,-0.041758556,0.061338834,0.049693476,-0.018906768,0.013297192,0.02766787,-0.027671907,-0.013048329,-0.03958602,0.020645177,0.04807143,0.00031902487,0.024218582,-0.08703872,-0.022108877,-0.039244577,0.0042067487,0.03213302,-0.059551377,0.030685542,-0.049858496,0.0023112735,-0.010992253,0.08238535,-0.075692125,0.0083689755,0.03531031,-0.027871571,0.071547605,-0.022012409,-0.039117455,0.014514687,0.041652724,-0.049872402,-0.1035294,-0.03120128,0.014957906,-0.08579248,-0.101507634,0.09244149,-0.05082052,-0.061731488,0.018833043,-0.05363772,-0.040920757,0.011181543,-0.050709683,-0.0030363088,-0.084065855,-0.02369506,0.050261963,-0.05169544,0.05323319,0.0063330503,3.6310543e-33,0.03705945,0.025293384,-0.025066588,-0.055585403,0.0016096161,-0.065658055,-0.03156126,0.014475268,-0.07429141,-0.023792887,-0.047288723,0.009751419,0.010769561,0.11117391,-0.014055092,0.024982871,-0.004197201,0.055028353,0.092454225,-0.023538612,0.028145188,0.07951729,-0.020672983,-0.008544964,-0.049252126,-0.030937532,-0.035088647,0.093178615,0.04115976,-0.00015169044,0.08196518,-0.03203558,-0.023307445,0.05702553,0.019494506,0.021978669,-0.09857331,-0.0352165,0.039926834,0.0036413658,0.004599906,0.02418471,-0.08743275,0.0109412465,0.088393845,-0.012576027,-0.06907577,-0.009373157,-0.002661113,0.045465756,0.039023463,0.01704631,0.044352382,-0.03214519,-0.0052542426,-0.039025,-0.0066380645,0.06097974,-0.026961897,-0.06003853,-0.0067544505,0.08043928,-0.011593394,-0.071538836,-0.048046026,0.05651615,-0.12341727,-0.03160025,-0.06785627,-0.05629991,0.02976956,0.028843727,-0.03805186,0.06783152,0.045545295,-0.06554839,0.013967029,0.022218116,0.021115169,0.01709151,-0.053360138,-0.01217187,0.008536211,0.08798747,-0.0571885,-0.012863724,0.028379342,-0.115057,0.024699649,0.0027219804,0.00031380903,0.012141383,0.007934432,0.06514002,0.0859596,-4.2607354e-33,0.10029745,-0.070625566,0.049442362,0.04484907,-0.054030444,0.07727458,-0.007363855,-0.03293184,0.16086282,0.011772645,0.066648595,0.035331752,-0.010916805,-0.100782774,0.025264047,0.018561179,0.019348124,0.07122908,-0.015965048,0.027744226,-0.030698787,0.052243393,0.00542036,0.0671143,0.0369223,-0.0048094443,-0.047837794,0.012285915,-0.025273638,0.112392746,-0.03503494,-0.0120420335,-0.05519444,-0.056044005,-0.017228771,0.012230702,-0.056472126,0.09804501,-0.053135164,-0.0052613174,0.071071826,-0.020293638,0.08946994,0.06822566,0.106675416,-0.0025581876,-0.013498989,-0.023408804,-0.048660584,-0.07216852,-0.03420311,0.037537295,-0.004009501,0.026388489,0.13411976,0.17193647,0.06759745,-0.04968128,-0.010823914,-0.11611941,-0.04178502,-0.04630762,0.025186189,-0.042631324,0.070294105,0.039102145,-0.07343536,-0.007913549,0.06710859,-0.026784666,0.067108214,0.008159444,0.02424061,-0.0006522525,0.07003558,-0.052629296,-0.046724737,-0.07658485,-0.03210577,-0.05462439,-0.032936905,0.026712535,0.024061913,-0.035395723,-0.040198527,-0.026323615,0.0058442988,-0.024476212,-0.018418303,0.051264107,0.04993834,0.027824476,0.052000217,0.013166198,0.043963652,-3.3735308e-08,0.049392022,-0.04751356,0.024529276,-0.07802745,3.3727232e-05,-0.0024424323,0.0066134282,-0.036423214,-0.013412359,-0.033211995,-0.025881547,0.057455778,0.09569655,-0.069984674,0.058374252,0.03069262,-0.029998649,0.07258109,-0.06410949,-0.03446878,-0.09957725,-0.0038585754,-0.0070110275,0.016438926,0.020705635,0.0074964566,0.046953075,0.010225884,-0.03911846,0.054253593,0.047547292,-0.037935782,-0.036076505,0.021673398,0.043037225,0.00637506,0.04051505,-0.028266525,-0.07906551,0.048951067,0.009497384,0.015311678,-0.003223162,0.06550518,0.030458912,-0.013099799,0.05069098,-0.012720378,-0.046684492,0.033373144,0.015470198,-0.029156514,-0.066292204,-0.047598884,-0.07966264,-0.05845708,0.037363492,-0.031287596,-0.024294868,-0.046710122,-0.013192371,0.04560289,0.13550791,0.0015641666 +2.3.1.24,Acts on sphingosine or its 2-epimer.,384,1.0,-0.050787233,-0.06641852,-0.0044129943,-0.019367194,0.051306743,-0.039111488,0.0516767,0.068554826,0.035451256,-0.017053062,0.057526205,-0.05365836,-0.074798465,0.099604934,-0.00086411205,0.066269964,-0.052210543,-0.020186502,0.057538416,-0.06090752,0.06215333,-0.048370797,0.012664317,0.036226135,-0.03527145,0.0405263,-0.029661713,0.037440915,-0.00425979,-0.044076897,0.013516076,0.03716753,-0.06545321,-0.04117555,0.0056470875,0.07935678,-0.041083243,0.09173662,0.04734344,0.0009816524,0.06726985,-0.072848715,-0.02648799,-0.07465245,0.020663606,-0.0065370095,0.02654968,0.065875076,-0.024267454,0.050188456,0.010412809,-0.05348978,-0.023173861,0.017384319,-0.031005282,0.03791161,-0.14673984,0.0939211,-0.03273588,-0.009893893,-0.018412251,0.005295593,-0.092472576,0.049696475,0.00028635396,-0.04355229,0.048635993,-0.08128219,-0.0037253671,0.057009745,0.053325385,-0.010526504,-0.013898501,0.06086871,0.068634056,-0.029930487,-0.01191281,-0.06806628,0.01294427,-0.010672115,0.001255076,0.011274301,0.063911594,0.043225665,0.031983722,0.016771022,0.011225462,-0.029653747,-0.036193494,0.008995192,0.053204842,0.0033379793,-0.02148642,0.06646406,-0.023649605,0.059688535,-0.085099235,0.051063918,-0.005772916,0.020848844,-0.04115949,-0.007730807,-0.012904224,-0.0885647,0.030379912,-0.014003504,-0.009741167,0.012355835,-0.0142069515,0.059732534,0.048450027,0.023863146,0.07593591,-0.008418049,-0.02079023,0.07142057,-0.0671431,0.027252624,-0.01415262,-0.027185734,0.019178895,-0.020447575,-0.10058269,0.038890585,-0.062223807,-0.003042447,0.065290816,-1.4321766e-33,0.031346943,-0.03796432,0.05519225,-0.018542273,-0.026491584,0.040228937,-0.042813316,-0.052487664,0.006550738,0.0023980066,-0.02779522,-0.10873265,0.030561078,0.09149276,0.02799313,-0.052834436,-0.030365221,0.046257667,0.062475454,-0.013592581,0.015507243,0.06556559,-0.10034538,-0.036734585,-0.023115657,0.060346358,-0.08980928,-0.0220025,0.026849508,-0.0058334456,0.06705866,0.048591428,-0.055143204,0.032118183,-0.03062502,0.011920532,-0.009274118,-0.0017559306,0.0089154625,-0.01648669,-0.016071204,0.039068047,-0.04889556,0.014567521,0.034611035,-0.08658918,-0.048960295,0.05287725,-0.00043695446,-0.0032414733,0.081146464,-0.0037261483,0.09017564,0.06554599,0.019282468,0.0468564,0.04969301,-0.08059762,0.0476352,0.051550295,0.046320237,0.10361629,0.0348887,0.011696213,-0.021699632,-0.0331597,-0.06804662,-0.03732708,-0.1016283,-0.007302435,-0.0318572,-0.003481285,0.10310141,-0.058475837,-0.03004804,-0.040413253,0.008120818,-0.03080615,0.0076219323,0.009600449,-0.046649974,-0.13783579,0.0355379,0.00673609,-0.10260334,0.003916064,-0.035869144,-0.03169122,0.01044921,0.00825363,0.04732257,-0.063897654,-0.0780989,-0.013342439,-0.021316422,-5.8090543e-34,-0.0097531965,-0.0699841,0.03445819,0.04790611,-0.027048096,0.06085693,0.015301069,0.0056557558,0.026445078,0.0513354,0.012270805,-0.030927794,-0.0557729,-0.03306906,0.0028011866,0.06204776,0.04203925,0.06793151,0.016861243,0.01788699,0.009412453,0.09264517,-0.028710386,0.120147645,0.0024780931,0.0225376,0.04051002,-0.03459619,-0.024740886,0.046841424,-0.0692354,-0.099098116,-0.046971254,-0.061075,0.025291283,-0.011577574,0.051577702,-0.04699493,-0.053249847,-0.11525556,-0.0006704134,0.009956159,0.0095002735,0.17256021,0.07341433,0.114204526,-0.020707183,0.016806943,-0.09997243,-0.012060404,-0.083932534,0.010076028,0.018178472,-0.021131128,0.018804025,-0.004495724,-0.061359707,-0.09165703,-0.014237531,-0.030860173,0.022562886,-0.012817229,-0.10022598,0.019641338,0.093777694,0.03577367,-0.058069974,0.07152696,0.007949382,-0.018267704,0.03816677,-0.004102447,-0.06566721,0.008647803,-0.07000461,-0.020300848,-0.018561743,-0.084208265,-0.012054593,-0.019567981,-0.025471903,-0.023030167,0.03916868,-0.021660825,0.027392074,-0.018621488,-0.027060881,0.031747214,-0.04710266,0.03402237,0.03000658,0.034430154,0.03329272,0.056158595,0.0483869,-2.0619954e-08,0.04700474,-0.065121435,0.08329628,-0.089378096,-0.06357791,-0.06348595,0.074271396,0.02670857,0.043638326,-0.09474626,-0.069002494,0.044982363,0.07805661,0.016595326,0.15884905,0.020689312,0.055022907,0.010314917,-0.10543516,-0.114489906,-0.09174155,-0.051313743,0.014910511,-0.02937336,-0.02212524,0.025627755,0.07022928,0.12096686,-0.041192338,0.013451824,-0.011074921,-0.033959866,0.015024254,0.053417455,0.05973687,0.05684987,0.0039025617,-0.016441135,-0.036091987,-0.00870002,-0.09701794,-0.08358183,0.014468495,0.025714349,0.021917248,-0.02176319,0.019324608,-0.06302269,0.07565627,-0.005345268,0.05377168,0.0014201999,0.001089599,-0.011236344,-0.07149444,0.04182316,-0.0667233,0.0027020662,0.055436246,-0.06828814,0.011542741,0.042946547,0.038132403,0.030989684 +2.3.1.26,"The enzyme catalyses the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A. The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA. In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol. In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of `foam cells', a hallmark of early atherosclerotic lesions. In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the 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+2.3.1.29,"This is a pyridoxal-phosphate-dependent enzyme that acts in concert with EC 1.1.1.103, L-threonine 3-dehydrogenase, in the degradation of threonine to form glycine [3]. This threonine degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex [4]. 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+2.3.1.35,"Also has some hydrolytic activity on acetyl-L-ornithine, but the rate is 1% of that of transferase activity.",384,1.0,-0.016297419,-0.10045559,-0.008716489,0.0027071605,0.08328764,0.02324882,-0.028351253,0.0551089,0.024611346,-0.04199689,0.02384455,-0.026523799,0.028688068,0.06660442,-0.09949633,0.06604218,-0.009325122,-0.01679287,-0.067978226,0.015194095,0.05128053,-0.043150652,0.04339577,-0.06275563,0.07958315,0.0009741256,-0.047725517,-0.038978864,0.012735998,-0.109136514,-0.053224813,0.01926693,-0.036014494,-0.050138388,-0.04334962,0.08523737,-0.07200453,-0.0070439735,0.00036009366,0.039826855,0.09227615,-0.08018865,-0.08716872,-0.029337512,-0.027123725,-0.037432637,-0.08345004,-0.012921109,0.007871801,0.058440275,-0.010400505,-0.04973461,-0.0021281242,0.069992885,-0.07820745,0.00016405256,-0.020299768,-0.017459253,-0.014974455,0.045997053,-0.028040336,0.053894877,-0.028611291,-0.005154995,0.01933136,-0.039436385,-0.0018324229,-0.029725434,-0.04206317,-0.020661172,0.00031025297,-0.045902245,-0.011913912,0.044496033,0.018379834,-0.090664044,-0.04196179,0.010862991,0.03194071,-0.03848262,0.03270765,-0.05638866,-0.07099469,0.050677028,0.038330834,0.030011872,-0.020645713,-0.002346382,0.0021363522,0.008255666,0.002817468,-0.015300966,-0.04102836,-0.07799912,0.025642145,0.03097639,-0.004064937,-0.010391178,0.006855278,-0.035838865,-0.042492867,0.050436247,-0.07252538,-0.066895954,-0.07290078,-0.0042561176,0.08232098,0.028471576,0.044550136,0.04489245,-0.01565231,-0.0449388,0.047685932,0.042297784,-0.06109471,0.07967662,-0.035862304,-0.052075952,-0.014596376,-0.009821031,0.01725769,-0.041549314,0.033027425,0.090564854,0.00028810705,0.07139396,0.028517675,4.535628e-34,0.057719912,0.03291461,0.023117155,-0.020234823,-0.01237447,0.02696575,-0.05539099,0.04111739,0.09465702,-0.1450652,-0.08119429,-0.03484366,-0.008532192,0.06756273,-0.045570377,-0.041152306,0.02258294,-0.045712434,0.06757008,-0.03541804,0.018637564,-0.0054171733,-0.11485266,0.080584385,-0.007895697,-0.045173816,-0.002131885,-0.012492594,0.060697187,-0.036178615,0.049623713,-0.027631199,-0.052894086,-0.031005418,-0.019117055,0.067748316,0.025587086,-0.0119972145,0.058202807,0.040990844,-0.0041651623,0.007858894,-8.705208e-05,-0.0350264,-0.024982862,-0.0102744,-0.10718928,-0.004287948,-0.04517873,0.022231996,0.04122429,-0.02726959,-0.020154312,-0.044595838,-0.03909779,0.0286573,-0.012230739,0.01963936,0.036361538,0.10878007,0.016571749,0.09516447,0.09199289,-0.059879698,-0.03936384,0.023004001,-0.060957495,-0.024665935,-0.011794182,0.043013535,-0.09543002,0.010324486,0.09939912,0.023977311,0.04632262,-0.0064360816,-0.027690848,0.03678396,0.046784308,0.03207293,-0.005452553,-0.08585009,0.055529635,0.016137265,-0.030944856,-0.01901555,0.0059732646,-0.08927764,-0.0069832522,0.04938192,0.10345988,-0.009712508,-0.05107024,-0.02134297,-0.007429373,-2.4350378e-33,0.027507046,-0.09420881,0.086193815,0.037407286,-0.0088889105,0.06495265,0.0083645405,0.06044155,0.075688004,0.0720635,0.05910338,0.056248743,-0.030424723,-0.07845506,0.038476225,-0.0019679838,0.0071566016,0.07382019,0.0057614096,0.056039345,-0.030301444,0.07622494,0.058283225,0.07912489,0.06468801,0.028564462,-0.07636069,0.0033064648,0.025405155,0.066825636,0.017916791,0.007991772,-0.05254934,-0.05379283,-0.03658131,0.03919698,0.03313345,0.033195503,-0.06574761,0.009525213,-0.017389268,-0.040812973,0.01209659,0.011913569,0.030853815,0.05431499,-0.024821708,-0.091526344,-0.019404866,-0.026103947,0.08308926,0.054777857,-0.049689,0.023521379,0.06376296,0.082318015,0.018082626,-0.05453365,-0.035141315,-0.0737179,-0.008769113,0.038379494,-0.09150939,-0.048298843,-0.009694084,0.076067485,0.010624185,0.08888074,0.041833736,-0.030190459,0.033301573,-0.0027351824,0.12524395,0.035734165,-0.04570307,-0.01756648,0.019404259,-0.117353186,-0.032609757,-0.06797856,-0.096526064,0.06094737,-0.08345938,-0.13228507,-0.08010772,-0.04269029,-0.021643074,0.035462253,-0.021753598,0.04203601,-0.04944635,-0.03014322,-0.09039627,-0.013012931,0.061187994,-2.7289635e-08,0.040166058,-0.06843363,0.10173026,0.036412593,0.014327096,-0.019086653,0.03617033,0.06783009,0.032482516,-0.030604763,-0.038658336,0.12112677,0.006470167,-0.03845619,0.03144123,-0.016873775,0.07730341,0.054881155,-0.023411682,-0.06538822,-0.0119213555,0.023536246,-0.03214958,0.00560117,-0.038235456,-0.030073496,0.08809418,0.09330972,0.032847136,-0.14206453,-9.393946e-05,0.016657041,-0.0055028317,0.0019765005,0.06084295,0.046129305,0.0071305637,-0.038015805,-0.01888978,0.05585859,-0.039719637,-0.046481308,-0.025768736,0.02694747,0.011134464,-0.031188563,-0.024806764,-0.047467895,0.076587684,-0.036998916,0.066566415,-0.011738133,0.015905192,-0.05751675,-0.07601383,0.046368685,-0.05484085,-0.07725724,-0.019306568,-0.07989718,0.023577375,-0.0020699971,0.15490793,0.026126206 +2.3.1.37,A pyridoxal-phosphate protein. The enzyme in erythrocytes is genetically distinct from that in other tissues.,384,0.99999994,-0.028714834,-0.05166442,-0.08810446,-0.02167374,0.039502945,0.022038668,0.056625884,0.015859311,0.036560245,0.013262681,0.019799,0.011419871,-0.09155273,0.055324472,0.035933625,-0.014208438,-0.0349462,0.026507871,-0.0383258,-0.083196886,0.07025562,-0.0030150828,0.022917425,-0.021044325,0.038236577,0.020203907,0.066959254,0.043536182,-0.038252715,-0.06797417,-0.044344332,-0.08671117,0.037175518,0.0019059847,0.016926222,0.0847759,-0.12776203,-0.013031605,-0.014351443,-0.07609773,0.10414801,-0.045090914,-0.062529944,0.044270426,-0.06338481,0.023693658,0.051329494,0.023493435,0.055071548,0.013647682,-0.045016255,0.0032893117,-0.072919466,-0.031090235,-0.0339182,0.022544095,0.024652716,-0.0036247054,0.004730619,-0.0357456,0.008202083,-0.02011335,0.017807864,-0.032214254,0.0529045,-0.006807278,0.07360287,-0.055831797,-0.050793584,-0.063483804,0.0017237442,-0.046538148,0.014390236,0.09957013,-0.015351807,0.06222123,-0.020233128,0.0650375,-0.0500486,0.054975636,0.01745903,0.015839951,0.033813532,0.08921416,0.021463571,0.07572795,-0.054401085,0.040040284,-0.07915526,-0.057299953,-0.013086659,-0.052527238,0.02730301,0.042544466,0.011332659,0.019281631,-0.035449006,0.008360362,0.028359834,-0.07251129,0.00872485,0.020460604,0.043026987,0.026207209,-0.041167952,-0.017004335,-0.060493402,-0.011207746,-0.029192552,-0.06823655,-0.043487564,0.030903134,0.019502062,0.042344093,0.024789264,0.027881969,0.010979134,0.008309618,-0.0669482,0.12564042,0.02694727,0.005889288,0.030328847,0.09886305,-0.01690873,-0.058150604,-0.08636485,-6.1482206e-35,0.022099113,0.06907148,0.031989947,0.02707216,-0.014401635,0.049627017,-0.025927134,-0.011842588,-0.010927004,-0.005725105,-0.048952606,-0.060551886,0.10771178,0.03729162,-0.09211004,0.011191149,-0.10746873,-0.006839421,0.11894439,-0.013644522,0.007941191,0.08022151,-0.0333929,0.004284792,-0.073184304,0.05463949,-0.0871871,-0.0034880664,0.035389546,-0.017368572,0.04737689,-0.12260849,-0.05460219,0.049603436,0.03359393,-0.056636162,0.00053308334,-0.029660909,0.00031641964,-0.032951627,-0.0722972,-0.015207953,-0.033548195,0.014444701,0.065727144,-0.12126887,-0.06600063,0.006555167,-0.011518679,0.035215683,0.030477427,-0.052210294,0.12557049,-0.064540714,-0.06774544,-0.025845515,-0.019277519,0.05514783,-0.011652634,0.06992051,0.107823335,0.028627882,-0.047150116,-0.013911834,0.022179238,0.06364037,0.0013441275,-0.050071135,0.016513828,0.07659167,0.069133334,-0.054477677,0.06322677,0.016686298,-0.03427973,0.008102022,-0.031220548,0.0849147,-0.045916826,0.03574808,-0.054278865,0.010296541,-0.06630891,-0.017643072,-0.06206231,-0.007349413,0.032101326,-0.059469413,-0.008100157,-4.0166564e-05,0.09475469,-0.074139655,-0.11423129,0.009899632,0.042940788,-1.455686e-33,0.09332333,-0.06797087,0.0039292728,-0.03906187,0.0057022045,-0.003537924,0.11605698,0.017021485,-0.008569878,0.09529643,0.07917915,-0.025406174,-0.03217785,-0.06662215,-0.01999665,0.051997703,-0.016425911,0.01740506,0.039127234,0.04132457,-0.066019595,0.0456741,0.045244183,0.08524885,0.048216768,0.049541667,-0.049289744,0.0025109116,-0.033559076,-0.050982717,-0.043838106,0.029783785,-0.04288114,-0.07633115,-0.04361996,-0.017165089,-0.033585634,-0.0021860714,0.00092511834,-0.05950522,0.05147265,0.080496505,0.043905243,0.000118221455,0.043744303,0.064456664,0.0016255723,0.044567745,-0.043433808,-0.037058428,-0.02644232,0.08571257,-0.012636694,-0.003328644,0.0056808363,0.026926365,0.060904525,0.019710178,-0.0028884858,0.012880421,-0.033888426,-0.06920349,0.0051242765,0.123651505,-0.0004008092,0.048498094,0.016677804,0.030705726,0.0127155185,0.08895943,0.055434927,-0.008494596,0.017351137,0.048475116,-0.091716826,-0.005417735,-0.020751864,0.054506663,0.03301706,-0.034284856,0.02384145,-0.028575823,-0.08161079,-0.045743432,0.02695253,-0.075078085,0.0028297338,0.085200936,0.03529251,-0.009731774,0.053036496,-0.073364414,-0.069186226,0.033945683,0.059794787,-2.7841201e-08,0.09121175,-0.057255,9.776794e-05,-0.07004022,0.0005462906,-0.053335946,0.0352038,0.034908153,0.0382754,0.023865242,-0.00024653424,-0.029054254,-0.0025381208,-0.034719598,0.07953927,0.058831524,-0.010437915,0.021423196,0.042302214,-0.03911839,0.042189974,-0.014106268,-0.09250793,0.043093942,0.08170363,-0.0051501147,-0.054243483,-0.072295085,0.029429983,-0.007922518,0.054540247,-0.043219857,0.008875492,-0.0375378,-0.045791794,0.04895742,-0.00367605,-0.034002133,-0.070190966,-0.039014254,-0.06606647,-0.01889658,-0.0018571987,-0.047393277,0.021278547,0.060887672,0.015402224,-0.08852355,0.018187037,-0.07616457,0.0036797558,-0.06033562,-0.063220635,-0.08003606,-0.17279434,0.054179206,0.00013008248,-0.054018933,0.034791656,-0.028264225,0.0074640745,0.07705922,0.10626993,-0.04818248 +2.3.1.38,"This enzyme, along with EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. The substrate acetyl-CoA protects the enzyme against inhibition by N-ethylmaleimide or iodoacetamide [4]. This is one of the activities associated with beta-ketoacyl-[acyl-carrier-protein] synthase III (EC 2.3.1.180) [5].",384,1.0,-0.07314134,-0.023886207,-0.07615711,0.036318142,0.040244892,0.09110308,-0.10673818,-0.012605896,0.050388172,-0.08160804,0.049725134,-0.107760444,-0.053318333,-0.022627275,-0.0519869,0.0044648545,-0.011570186,0.020948937,0.018651808,-0.09955514,0.032551344,0.031221338,-0.023112264,-0.005142025,0.0064448784,-0.005510491,0.05419382,-0.02300673,-0.025029605,-0.13247697,-0.0019351377,-0.12738712,0.08143611,-0.03378671,0.06244764,0.043955006,-0.011089069,-0.07043787,0.086237796,0.013801213,0.046079807,-0.109487034,-0.0423219,-0.011248109,0.0038539132,-0.035806913,-0.039095026,0.023557091,0.059120663,-0.054934908,-0.048703484,-0.063958436,-0.022190548,0.022844354,0.009801513,0.018409424,-0.020796664,-0.020595491,-0.05485496,0.001768808,0.03823456,0.016788363,0.012770094,0.00781625,-0.05341669,-0.056233823,0.050596576,-0.09016657,0.038114663,0.0074466704,-0.074364334,-0.13735719,-0.0092902975,0.100842595,0.04279869,-0.01317019,-0.036962777,-0.05466664,0.056043394,-0.0061942576,0.013283499,-0.03874384,-0.013810243,0.011310739,0.010153164,-0.051427267,0.012118627,-0.010835503,0.018687852,0.05602054,0.009037139,-0.056824613,0.030258495,-0.006644073,-0.025125623,0.06662161,0.012143549,-0.030905576,-0.0059282435,-0.04272005,-0.016331917,0.071385495,-0.063639104,-0.009166586,-0.05039433,-0.020989694,0.0026302077,0.05695271,-0.02196367,-0.0039332984,0.025328452,-0.042898137,0.03168292,0.020099286,-0.030793281,0.082917385,0.005710323,-0.06915301,0.023885297,0.029906925,-0.0031191255,-0.05996728,0.03136764,0.063830346,-0.023392046,0.0109276585,-0.07288682,-1.2754087e-33,0.09200996,0.03252514,-0.023777397,0.00037508243,0.03306059,-0.07218514,-0.062349167,-0.008023367,-0.0034556952,-0.046517823,-0.016649181,-0.120276384,0.02368637,0.034433965,0.035245787,-0.003066445,-0.0005190007,0.001119833,0.08548846,0.020688908,-0.012255264,-0.0246708,0.027400514,-0.016749548,0.041359123,0.05777825,-0.021433968,0.013019054,0.086038865,0.055915482,-0.05274092,-0.060520697,-0.024312096,0.0100989025,0.03238837,0.006828203,0.00542004,-0.024626771,0.012029498,0.069680125,0.046385117,0.035669655,0.004714475,-0.046285965,0.002878769,0.03320302,-0.06366553,0.09275392,0.042596225,0.044513617,0.066234484,-0.06809034,0.07676259,0.010602682,-0.007304043,0.053383954,-0.10196831,0.0016414092,0.0051517067,-0.020200897,-0.023342067,0.084704325,0.016057968,0.022071322,0.0035456736,-0.0020118724,-0.078984044,-0.05926186,-0.07677874,0.07090739,-0.031112136,0.00040540483,0.07102738,0.06354757,0.016940586,-0.02318452,-0.08535319,0.04683512,0.0381817,0.006674013,0.018399725,0.015579999,0.037394267,-0.05245031,0.005835332,-0.032496214,-0.034780316,0.022582497,0.048109192,0.0020865733,0.06328364,-0.03774145,-0.008269535,0.11723416,-0.04741096,-1.4001479e-33,0.13261959,-0.14749537,0.06366448,-0.12144592,-0.09086268,0.074096166,-0.0107659325,0.0027085461,0.038741585,0.06879521,0.067791045,0.057753377,0.04807633,-0.06535127,0.026465029,-0.058653392,-0.017320829,-0.00869087,-0.039670583,-0.049265128,0.018955765,-0.028270189,0.0035914404,0.09628625,0.009861157,0.018382624,-0.08590915,0.100041725,-0.0031453443,0.019805253,0.028372327,-0.025379628,-0.0052814134,-0.078413546,-0.04480151,0.073084615,-0.037841443,0.057382204,-0.026312806,0.050982494,-0.0032286528,0.03812651,-0.01312673,0.002719468,0.058247894,0.023719514,0.03248196,-0.022496618,0.058252543,-0.15940166,0.010219915,-0.012099357,0.021262921,0.007374452,-0.009734902,0.11284382,0.0077912165,0.06731452,0.053248186,-0.07740986,-0.072396584,-0.07173365,0.020307705,-0.023866624,0.07315316,0.0677993,-0.050685197,0.040256612,0.058791954,0.03709289,0.02938623,-0.009117094,0.021972043,0.06569629,-0.02589598,-0.082780965,-0.06868103,-0.043539185,-0.0072696237,-0.011884023,-0.035179578,-0.025800357,-0.05713572,-0.059129883,-0.09490617,-0.03849218,0.058240466,0.08472925,-0.012476317,0.0042284112,-0.040522765,0.006912563,-0.09185568,0.057933778,0.024930153,-4.137228e-08,0.08483326,-0.06767528,0.030908065,-0.0015759787,0.009378959,0.045315467,0.0015914941,-0.0076033105,0.074903466,-0.06020524,-0.08843051,0.088726215,0.062968045,0.060503237,-0.013887197,0.014109993,-0.0014649684,0.06366685,0.030884799,-0.07801617,-0.041030366,-0.02317466,-0.016179075,-0.011787052,0.02486979,-0.047139835,0.08129235,0.042465925,-0.039742738,-0.021813702,-0.04344217,0.02047199,0.009053317,0.036863912,-0.0227332,-0.0036583345,-0.034057938,-0.071404316,0.026098145,0.07968185,0.047482625,0.040034693,-0.035333443,0.028697709,0.053588852,0.043653294,0.047745135,0.03665853,-0.024578886,-0.061538607,-0.009938001,0.0011760268,-0.07360462,-0.009452737,-0.056335602,-0.015627969,-0.06484849,-0.07731984,0.029859211,-0.03345096,0.047417004,-0.009828186,0.16575697,-0.0012884103 +2.3.1.39,"This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis [7]. The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7, holo-[acyl-carrier-protein] synthase) is the preferred substrate [5]. This enzyme also forms part of the multienzyme complexes EC 4.1.1.88, biotin-independent malonate decarboxylase and EC 7.2.4.4, biotin-dependent malonate decarboxylase. Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase [12]. In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot [10] whereas the enzyme from Pseudomonas putida can use both as substrates [11]. The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate cofactor; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA cofactor.",384,1.0,-0.077853434,0.0021570101,-0.08957135,-0.012170608,0.033748034,0.037282277,-0.052859966,0.029969538,0.0013293064,-0.0772463,0.014981259,-0.052442722,-0.013578391,-0.014591132,-0.008659636,0.0061201476,-0.029449664,0.006934774,0.0133851245,-0.057409853,0.07941345,0.054799978,-0.048703197,-0.057727214,0.040760357,-0.03306016,0.052663576,0.0098076435,-0.044474293,-0.110269755,0.04906445,-0.0941204,0.022538647,-0.044288643,0.04224726,0.08036346,-0.037669305,-0.08663856,0.14710562,-0.022263931,0.096522436,-0.039199658,-0.01813402,0.010361291,0.02082222,-0.036150794,-0.09084604,0.023061052,0.013120507,-0.04909576,-0.08559856,0.011017138,-0.008254392,0.024817983,-0.0028242301,-0.017958056,0.009754544,-0.005869306,-0.026173975,-0.029064007,0.049357276,-0.024921333,0.020578688,-0.01250008,-0.043411054,-0.02717753,0.0108772805,-0.058841802,0.06396758,0.030715194,-0.08819991,-0.052909072,-0.059505206,0.1151682,-0.0028853854,0.031119348,-0.05871474,-0.0098457495,0.005017449,0.048965123,0.008218581,0.0064361654,0.008112294,0.018063933,0.019012513,-0.08423843,0.05809087,0.036019262,0.004510605,0.10438408,0.019031378,-0.052453656,0.04349742,0.013586149,0.0046316,0.012354857,0.07510464,0.0067341304,-0.016690344,-0.052203942,-0.008610163,-0.0068402565,-0.012497292,-0.049752936,-0.046695165,-0.019902548,-0.050592728,0.06510256,0.027344685,0.012069069,-0.05589946,-0.043217566,0.03363215,-0.028168185,-0.012806348,0.14018048,0.0063735438,-0.06703577,0.023288395,-0.020767039,0.01818656,-0.06055953,0.034618314,0.027774699,-0.010328724,-0.010035521,-0.15012302,2.0580787e-33,0.044991698,-0.055429,-0.0113211395,-0.008011439,0.025914164,-0.064329065,-0.08769433,0.058767736,-0.057427734,-0.018545343,-0.05641518,-0.10661189,0.017741561,0.015022899,-0.05773521,0.01640953,-0.013246899,0.018450093,0.0780098,0.02591721,0.012258248,0.06197256,-0.011263815,0.04605256,0.012433782,0.03801295,0.0027269656,-0.02518891,0.016120598,0.016299222,0.013658717,-0.07289904,-0.030598873,0.02811751,0.054508846,0.027887955,-0.02650506,-0.032684643,0.037735082,0.034585573,0.12552698,0.037870992,0.06229646,-0.033562586,0.08421861,0.089862585,-0.06675235,0.041083653,0.023657484,0.024589168,0.04339708,-0.029108422,0.016182525,0.053930506,-0.03847312,0.0013648975,-0.10800645,0.066366866,0.0545568,-0.023731569,0.030471515,0.027086124,-0.0180852,0.039965183,-0.026827816,0.012035163,-0.050666843,-0.023173884,-0.02599629,0.059590288,0.01595191,-0.02655461,0.07715916,-0.009768559,0.10668506,-0.011376731,-0.07661494,-0.006268217,0.0036337662,0.012907072,0.016875366,0.0491359,-0.03499249,-0.07926449,-0.038543258,-0.06959339,-0.0846108,0.037008382,-0.010004824,0.009616426,0.02556261,-0.010880752,-0.01063436,0.09238452,-0.052511577,-3.9923704e-33,0.13751927,-0.17944351,0.090204835,-0.07400059,-0.039653197,0.05359955,0.04832375,-0.014548481,0.022607004,0.017234357,0.06426636,-0.0004327904,0.05475571,-0.024485186,0.01576696,0.031712256,-0.019482814,0.041493993,0.010348259,-0.0010957292,-0.013426909,0.059990622,0.010170665,0.01997927,0.016998125,0.025119249,-0.017666617,0.09051184,0.045914527,0.076552786,-0.03974266,0.028257772,-0.026259068,-0.017653894,-0.14989454,0.008175335,-0.08829343,-0.030046418,0.029892486,0.048207257,0.021729652,0.02014713,-0.05015788,-0.013416655,0.09377661,-0.037624802,-0.0015201725,-0.023980003,0.051789854,-0.07383384,0.029268263,0.015643118,0.0011136074,-0.004966689,-0.023800367,0.13484295,0.013860921,0.024424698,0.015905406,-0.07737095,-0.05790768,-0.015923262,0.058075894,-0.006863572,0.017944023,0.13190933,0.0058600656,0.018398369,0.050454237,-0.05364943,0.016304849,0.01381282,-0.0041963174,0.064896844,0.06420821,-0.04388533,-0.0940672,0.018357279,-0.053338625,-0.024100114,-0.0910129,0.0015667531,-0.023491183,-0.05892887,-0.055207137,-0.034808554,0.004260153,0.09231879,-0.04359322,0.08045957,-0.018904723,0.026400901,-0.058145665,0.07887301,0.07439516,-4.5272984e-08,0.02608049,-0.028461777,0.029943135,0.002577333,-0.0021142021,0.040304143,-0.02769165,-0.026115242,0.048906766,-0.06893164,-0.01692748,0.050119698,-0.028056726,0.06320305,0.037946813,0.009075416,-0.06301762,-0.023523506,-0.0052290643,-0.07298086,-0.062477283,-0.0178914,-0.002219966,0.06094898,-0.02895787,-0.02168533,0.019723253,0.0127304215,0.036802717,-0.035734974,-0.09437481,0.07034391,-0.020339176,-0.058824345,-0.044187386,-0.03336202,-0.053381857,-0.12134877,0.04196123,0.07504413,0.06905885,-0.013650775,-0.05291358,0.023506645,0.061872244,0.006589579,0.047463685,-0.011566691,-0.048242673,-0.04714462,0.05875211,0.035871767,-0.061331026,-0.0070793,0.008172042,0.08315081,-0.098842196,-0.07659161,-0.028000712,0.006547001,0.0029230863,-0.014475913,0.15057877,-0.043486767 +2.3.1.41,"This enzyme is responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids. The enzyme can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16) [4]. The substrate specificity is very similar to that of EC 2.3.1.179, beta-ketoacyl-ACP synthase II, with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C16Delta9) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature [4,5]. ",384,0.99999994,-0.07298909,-0.09844195,-0.065798715,0.04096051,0.03830166,0.045814455,-0.13145508,0.042259376,0.018550536,-0.07921689,0.054415636,-0.09449494,-0.0635269,-0.0024558995,-0.015132253,-0.011749876,0.016745785,-0.0047970666,-0.017684944,-0.10724796,0.024289059,0.010847666,-0.049799237,-0.028579334,0.0015411351,-0.008674056,0.0724765,-0.014461016,-0.063994855,-0.10193308,-0.043431193,-0.07370464,0.008774924,-0.027341353,0.05923995,0.02892713,-0.01905554,-0.11525345,0.10719586,-0.04504499,0.048902225,-0.0061170836,0.0032591743,0.011472109,0.024812642,-0.060766835,-0.011701306,0.06015765,-0.0082847215,-0.063662656,-0.06258738,-0.05142429,0.007840526,-0.0007838991,-0.040697403,0.009408344,-0.014149554,-0.016787449,-0.0041847215,0.03760701,0.052899003,-0.01085951,0.020937389,0.009859013,-0.03357558,-0.06251942,0.053977896,-0.09090915,0.019428015,0.0143478485,-0.10735575,-0.044065192,0.038928527,0.06299869,0.050595984,0.006106949,-0.010215173,-0.038628027,0.07594554,-0.0092948545,0.014566995,-0.006791774,-0.017697461,0.022618512,0.033830673,-0.07238684,0.069706716,0.01296475,0.0032697527,0.07788157,0.02662033,0.0025599268,0.0011961911,-0.043346066,-0.056869864,0.040348563,0.012050064,-0.030165471,-0.020932084,-0.06654346,0.007311782,0.06541043,0.020799855,-0.0066711684,-0.0139955105,-0.032688737,-0.011935031,0.060525287,-0.020423725,0.02502152,0.004299416,-0.012709657,0.019450689,-0.010399812,0.022354037,0.0412824,-0.038208492,-0.09199209,-0.008786805,0.039911333,-0.005412894,-0.101571575,0.025846155,0.06931787,-0.05825362,-0.024686487,-0.13542315,2.1757916e-33,0.0255301,0.03868249,-0.014157485,-0.054172993,0.10748242,-0.09855424,-0.11034321,0.009888089,-0.06517098,-0.02215353,0.027341343,-0.08766368,0.04214443,0.015588677,0.020009119,-0.02318014,-0.010495485,0.07663461,0.058406513,0.010134636,-0.017028864,0.07868268,0.061578047,-0.016705934,0.043161415,0.048020083,-0.027909542,0.044280384,0.0018252454,0.016877115,-0.02747585,-0.021125738,-0.06676849,0.054927874,0.09814744,-0.0032031278,0.011920914,-0.06536036,-0.0110971555,0.07232649,0.07857132,0.04601429,0.033727385,-0.036671974,0.0713009,-0.03520496,-0.0476751,0.06098758,0.030786205,0.01820387,0.06914681,-0.0035709052,0.10225392,-0.022373123,-0.005660321,0.009647397,-0.11762586,0.018589832,0.037934065,-0.051051065,0.0006732894,0.05657236,-0.07824635,0.03455609,-0.08644636,0.038063154,-0.09242276,-0.035987414,-0.003978277,0.120975845,0.047961105,-0.032525923,0.04887234,0.0652675,0.0728111,-0.050123524,-0.06169486,0.05951495,0.010120047,0.003829784,-0.009100916,0.030289771,0.02053007,-0.045138333,-0.04019169,-0.04826505,-0.042655274,0.05713486,0.078583784,0.052755598,0.040478382,-0.033153716,0.0046610157,0.10014015,0.031631075,-3.8188366e-33,0.10268042,-0.09204172,0.047851138,-0.10692429,-0.10138466,0.032359675,-0.0070873783,-0.019106753,0.06367897,-0.08339059,0.08095731,0.008666395,0.028573226,-0.060482584,-0.017914599,0.017518075,-0.03067869,0.02577673,-0.01275184,-0.044244956,0.043331996,-0.05716073,0.024622539,0.075747445,0.024575327,0.040262617,-0.041581802,0.09718284,0.030566683,0.02825071,-0.005180153,0.014356058,-0.0378836,-0.043392427,-0.06417022,0.012774645,-0.08228727,0.05675384,0.011294936,0.07758722,0.043936048,0.04179267,0.0059439894,0.012549184,0.04516603,0.024234919,0.049889233,-0.06966652,0.039857633,-0.16080993,0.027103728,-0.04701056,-0.03265492,0.013621004,-0.011038108,0.11525951,-0.00088380155,0.047190465,0.026626183,-0.065166526,-0.05529404,-0.08965877,0.059884615,0.005481958,0.069940016,-0.0052822176,-0.037773997,0.011887125,0.019457582,0.05739394,0.021201896,0.06278252,-0.008945414,0.0276452,0.014995161,-0.01662287,-0.05011116,-0.039685532,-0.013749053,-0.014503513,-0.0267746,0.024258234,-0.06179822,-0.042039454,-0.060975984,-0.02328618,0.047606118,0.06266243,0.0032813083,0.049142912,0.0027878794,0.018355388,-0.020323465,0.0406215,0.054070983,-4.423251e-08,0.05491546,-0.016765768,0.03145655,-0.024381123,0.0030337856,0.05937306,-0.004102252,-0.058527008,0.09639435,-0.049715854,-0.09956873,0.10978616,0.083002694,0.049991015,-0.021209762,-0.009043624,-0.055964928,-0.03270256,0.057246786,-0.022954902,-0.08027596,-0.055019073,-0.009120674,0.025831554,0.015476328,-0.0387569,-0.009296845,0.015816856,-0.012510176,0.025764683,-0.101232134,0.039125517,0.03499606,-0.027004719,0.025307212,-0.025656043,-0.010633437,-0.07488428,-0.075851545,0.092386834,0.09317584,0.0148399295,-0.052967522,0.011315609,0.06484703,-0.013813277,0.056370296,0.014271338,-0.048765894,-0.031781565,0.059630033,-0.009286476,-0.042428445,-0.039828572,-0.036919635,-0.03836464,-0.017110141,-0.051766634,-0.035473272,0.014606475,0.024736395,-0.013140675,0.1276015,-0.027868716 +2.3.1.42,"A membrane protein. Uses CoA derivatives of palmitate, stearate and oleate, with highest activity on palmitoyl-CoA.",384,1.0,-0.052643187,-0.1153408,-0.030683247,-0.022548987,-0.00016213163,0.016764283,-0.028670995,0.08556749,0.069179036,-0.03814562,0.043260485,-0.015846774,-0.11001777,0.051195778,0.041497022,-0.04830765,0.019156277,0.053718213,-0.001089881,-0.028923191,0.07775131,0.018111855,-0.014502672,-0.0525021,0.02789804,0.039705265,0.023425603,-0.074560516,0.072847955,-0.07219175,-0.0046849884,0.003570266,0.03492293,-0.07095015,0.00044650747,0.018477907,-0.027424036,-0.08449674,-0.009732614,-0.06518839,0.08983256,-0.07074874,0.01330779,-0.020487538,-0.017318785,-0.018804707,-0.010972566,0.037578117,0.03247698,0.009693651,0.00857553,-0.055986315,-0.08213338,0.015572508,-0.0293468,-0.00048414888,-0.033636577,-0.0038285512,0.020928873,0.03866514,-0.0060640033,0.016735608,-0.0017367982,0.04021258,-0.0075619314,-0.103126645,0.06785659,0.058099907,0.06761833,0.015259715,-0.0024901177,-0.031364866,0.013959965,0.083125286,0.012696259,0.038157944,0.019034352,-0.0336007,0.056135677,-0.03629632,0.027268365,0.06563184,0.003773363,0.1593003,0.047967672,0.02760888,-0.019940358,-0.046877857,0.018251963,-0.0024902509,0.062204335,-0.001971639,-0.024465645,0.024184179,-0.13850598,0.04804737,0.013703606,-0.021240668,-0.04641994,0.016546162,-0.014218489,0.06307358,-0.005212462,-0.09436159,-0.011354477,0.0043799533,-0.051356625,0.0152508365,-0.031925865,-0.004478532,0.0069848457,-0.0133517515,0.007891674,-0.050179902,-0.011960876,-0.047851887,-0.0054811556,-0.042137355,0.038232885,0.066656455,-0.05591642,-0.042330705,0.0143568795,0.06949928,-0.019063191,0.022416702,-0.02631835,-2.7754368e-33,0.028083552,-0.0110554015,0.005605561,-0.0029615415,-0.047764342,-0.101831324,-0.018324506,-0.013055126,-0.04933583,-0.020804701,0.0071982015,-0.055443663,0.003027019,0.105881326,0.07078398,-0.0054605613,0.0157213,0.027578397,0.05648042,-0.042899493,-0.0069789733,0.09852893,0.06089107,0.0111065535,0.097064726,-0.09292001,-0.05470619,-0.009281063,0.07449139,0.026442926,-0.0028875694,-0.06310246,-0.055258807,0.035251163,-0.015123764,0.0055545885,-0.033075124,-0.089457944,-0.056707773,0.049672533,0.041305937,-0.019411966,-0.06441896,-0.009422807,0.042733654,-0.058272056,-0.075204335,0.053771913,0.0070318347,-0.042086985,0.061045147,-0.010377112,0.01831165,-0.011726447,-0.06550199,0.016664695,-0.051739298,0.011169582,0.017540807,-0.003024523,0.036541972,0.03359603,-0.0745664,0.06532397,0.015966386,0.011246491,-0.11493707,-0.024560403,0.007737969,-0.020106832,-0.02307329,-0.08637149,0.019008875,0.029145908,0.053750012,-0.015480906,0.005389784,0.09341197,0.0875784,0.07880902,0.06837687,-0.0046971063,0.01582999,-0.017988233,-0.06004943,0.036744583,0.016470449,-0.030799989,0.026372945,-0.017871814,0.04906824,-0.017590886,-0.026942927,0.021528685,-0.0789363,3.4455066e-34,0.07006485,-0.06611933,0.05358487,-0.03681914,-0.059517384,0.011618,-0.020064227,-0.02533845,0.034536023,-0.06734058,0.057661094,-0.034587186,0.0036851813,-0.068010755,-0.016925069,0.06409256,-0.030237108,-0.045273792,-0.038341377,0.025617965,-0.08850042,0.029308308,0.07960135,0.10111598,0.011252637,-0.053852335,-0.024516143,-0.013666964,-0.0066501806,0.07491695,-0.00244325,-0.02416848,0.0053210855,-0.0046329964,-0.07684141,5.053588e-05,0.024720721,-0.014311378,-0.00836519,0.026766334,-0.026181202,0.023996513,0.07416014,-0.07751546,0.046679676,-0.003295706,-0.0704164,-0.039447278,-0.061681338,-0.057631515,0.07913474,-0.028548941,-0.026665429,0.010138688,-0.03128043,0.043966968,0.016257588,-0.026575048,0.027979763,-0.056061618,0.011922713,-0.012103393,0.006615227,-0.07951711,0.12328032,0.12208841,-0.053510975,-0.016292548,-0.009897163,-0.038474433,0.04064918,0.054040756,0.05057313,0.014702235,0.018371793,-0.0031992442,-0.03322975,-0.066034414,-0.07987027,-0.0058121807,-0.07774532,0.003039229,-0.051848166,-0.021862179,-0.002937134,0.07707183,0.005017753,0.0333957,0.05684287,0.061161432,-0.05606733,-0.05679916,-0.050088227,0.12604894,0.068624705,-2.7304209e-08,0.056693684,-0.04321281,0.0026078357,-0.037813433,-0.054587923,0.009544468,0.04100121,-0.06919298,0.04233792,0.030843148,-0.087650135,0.1053248,-0.0021959287,-0.009293482,0.035469506,0.016979808,0.007755387,0.015335929,-0.046749156,-0.11027426,0.016134957,0.023003962,0.03835957,0.08771376,0.038679212,-0.034527548,0.021648947,-0.00018767302,0.033339452,-0.0147076715,-0.002759007,0.03230248,0.01437522,0.022183305,0.040361695,0.06266232,0.06513339,-0.11084183,-0.06856402,0.22484961,0.07936885,0.012265722,-0.034283996,-0.019517329,0.056250427,0.003620921,0.027587567,0.12664385,-0.065186195,-0.02356864,0.03247057,0.02712877,-0.12172295,-0.028769186,-0.079089865,-0.07237661,-0.056790132,-0.058893695,0.014689557,-0.023587476,0.03049125,-0.017920746,0.17073098,0.007352196 +2.3.1.43,"Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase.",384,1.0,-0.057572287,-0.11306811,-0.076368526,-0.025425853,0.07461555,-0.007363743,-0.054543857,-0.00985832,0.0479777,-0.03571462,0.08954777,-0.045608353,-0.0923178,-0.005826176,0.07521762,0.0041800034,-0.070251465,0.08879388,-0.012481024,0.009768509,0.07184383,0.0072177732,-0.05870551,-0.024424732,-0.021083778,0.07984704,0.033960044,-0.021017976,0.00028109367,-0.12379071,-0.027497344,-0.053111337,0.008084896,-0.093693554,-0.004065504,0.03364754,-0.051632825,-0.06375242,0.035922386,-0.02295157,0.10068334,-0.07064177,0.06399726,-0.070016846,-0.0010712123,-0.028321369,0.032479387,0.0720953,0.03573639,-0.04644043,-0.0006483743,-0.06425124,-0.025515951,0.0049394723,-0.10379581,0.025886947,0.0026455042,-0.044975344,-0.008673023,0.03153638,-0.007526592,0.016346075,0.020199265,-0.010485895,-0.11549196,-0.07688727,0.040242083,-0.06847472,0.034008536,0.0774825,-0.09971105,-0.062208492,0.011016043,0.110338986,0.09867139,0.07145935,-0.025783597,-0.016460983,0.06443656,-0.04461918,0.028272245,-0.06583294,-0.05994529,0.096380316,0.08701258,0.010868177,-0.071540445,0.022003641,0.009393183,0.03323684,0.05136691,-0.019481244,0.100484274,0.001086943,-0.052733243,-0.013121979,0.02220911,0.04628787,3.2827782e-05,-0.017616777,-0.017231368,0.06970768,-0.066184886,-0.050609212,-0.0144725805,0.0024301943,0.014549986,0.0047181323,-0.02409224,-0.0019905702,-0.025289608,-0.063111596,0.10493265,-0.03680484,-0.039318822,0.025117742,0.0007906286,-0.11677412,-0.09612938,-0.022818226,0.01923161,-0.04944508,0.042611293,0.04723756,-0.056918442,0.045931846,-0.016285464,4.1315618e-33,0.03165623,0.073876776,0.006415921,-0.014215082,-0.038160544,0.0017232836,-0.028419165,0.0073815533,0.042340048,-0.10731414,-0.018462395,-0.015807314,0.020646239,0.07545554,-0.020999342,0.026251866,0.025196606,0.12374913,0.070988834,-0.04254073,0.032334667,0.04547873,-0.04803589,-0.011875002,0.0478445,0.020425407,-0.07666237,-0.02201024,0.060859654,0.025662942,0.018532448,-0.062771715,-0.06239611,0.045913346,-0.0017155578,0.04430744,-0.017143624,-0.06649261,-0.0073053115,0.016972193,0.006853599,0.014169835,-0.078828886,0.048664328,0.02247362,0.0024008292,-0.055509876,0.072002076,0.036280602,-0.012162031,0.0018188491,-0.054567616,0.019309124,0.0002981077,0.027987089,0.019328125,-0.02100031,0.023177953,-0.004440768,-0.0057443185,-0.003414156,0.14003935,-0.061550204,0.035387564,-0.015514427,0.03633833,-0.04066476,-0.06979701,-0.09412349,0.032602567,0.027232317,-0.0002533493,-0.017022228,0.083214395,-0.03907255,-0.0095700165,-0.036918245,0.04827633,0.009586911,0.024910843,0.0044554174,-0.035767354,-0.0068949913,-0.055503093,-0.03471173,0.043913364,-0.016042218,-0.016116112,0.0049042325,0.01542585,0.03416829,-0.07094872,-0.043974806,0.06305744,-0.056292016,-4.8169797e-33,0.049475957,-0.039293367,0.065455794,-0.013604927,-0.08445076,0.05318794,0.0061595594,-0.046533354,0.12273634,-0.014391098,-0.028602365,-0.034731876,0.086305544,-0.05567051,0.021983834,0.00031927926,-0.04179832,0.013989296,-0.045434974,-0.033696868,-0.008904251,0.022716641,0.09054845,0.16470334,-0.014136135,0.00328681,0.0018994266,-0.023522532,-0.0065071024,0.05419662,0.010933744,-0.03742785,-0.011475162,-0.06810889,-0.04710959,0.0066461223,-0.035265524,0.03528743,0.027713189,0.02928465,-0.011842546,-0.041669924,0.043789353,-0.042127892,0.0165568,0.012666651,-0.055193048,0.04677514,0.019593276,-0.043916736,-0.007936173,0.034303196,-0.0026226952,0.039950717,0.047450848,0.103839576,0.07185628,0.001341455,0.0465453,-0.11441175,-0.068853,-0.007024113,0.0032220467,-0.042649608,0.08770442,0.067830846,0.014427877,-0.030259728,-0.0006092633,-0.028098857,0.030295635,0.04599077,0.026596244,0.032459904,0.03759414,0.00046684872,-0.034484625,-0.052992534,-0.0198019,-0.09253338,-0.040282555,-0.025655419,0.09915192,-0.06770522,-0.043406025,0.012640107,0.017345103,0.030781534,0.031765193,0.017370924,-0.047654875,-0.008927169,0.023858277,0.027278073,0.072944164,-4.106507e-08,0.053688206,0.018734213,0.045642674,-0.043875813,-0.09634551,0.027373832,-0.042041447,-0.003588263,0.094279066,0.020300027,-0.066044815,0.1325403,0.078683995,-0.029687528,0.0366178,0.03582128,-0.0061019394,-0.034071624,-0.014738352,-0.1177891,0.0018890956,-0.029089915,0.027565908,0.0046864045,0.043059397,-0.044120792,0.03967733,0.033014726,-0.0070361346,0.027086603,-0.011722983,-0.063687935,-0.033679724,0.05280193,0.068500616,-0.004736852,-0.00789003,-0.087382235,-0.040766977,0.14523852,0.010794377,-0.0152401235,-0.11851976,-0.014182499,0.011706788,0.033868767,-0.0048398343,0.046420146,-0.029498994,-0.0076295417,0.0067008794,-0.052550595,-0.007378412,0.009315643,-0.08451929,-0.04730746,-0.024644425,-0.016753796,0.058033776,0.034319207,0.019528028,0.037246965,0.16813257,0.049678832 +2.3.1.44,Both free and glycosidically bound N-acetyl- and N-glycolyl- neuraminates can act as O-acetyl acceptors.,384,1.0,-0.086244896,-0.10087882,-0.067404635,0.0073347343,-0.018766645,-0.015905455,-0.018771453,-0.023985215,0.047500264,-0.04701095,0.07201525,0.07067365,-0.06586985,0.0617459,-0.039869145,0.03469378,0.05360171,-0.03978865,-0.0023411526,0.059612308,0.045347877,-0.036623713,-0.04061816,-0.056810193,-0.0018473823,-0.04330757,-0.014913814,0.029475916,0.04740893,-0.10087394,-0.023966942,-0.021089705,-0.0004934679,-0.014419837,0.011726514,-0.07074529,0.0006851757,0.012824,0.025923422,0.051154897,0.0019195729,-0.04067564,-0.018874956,0.020008583,0.03769893,-0.09103268,0.009452368,0.041956343,0.031056918,-0.024891466,-0.040941518,0.009149821,-0.041168418,0.033985715,-0.031272877,0.117600836,-0.15190658,-0.03897781,0.004890525,0.03671628,0.020497244,0.013397722,-0.046732426,-0.00074029213,-0.07848597,-0.041834902,0.07036781,-0.027590394,-0.045219954,0.091900185,-0.04933563,-0.0323477,0.009945683,-0.04558098,0.08560066,0.060164444,-0.06268916,0.016574746,0.08592047,-0.002186594,0.023006605,-0.032536812,0.00888812,0.09426381,0.044728544,-0.002099448,-0.04719121,0.020591045,0.043413747,-0.048003316,-0.012004488,-0.12745032,0.025291562,-0.07972817,0.009759377,-0.07350613,0.10290245,-0.0008750073,-0.036048755,0.02524663,-0.021836072,-0.007300122,0.022588212,0.007743114,-0.05601226,0.10007164,0.07370034,0.022280551,0.032957528,0.04013636,-0.09772318,0.0054389667,0.0676311,-0.0057402193,-0.09680743,-0.004134874,-0.10126988,-0.054191805,0.010980829,-0.096654326,-0.029128607,-0.00877801,-0.010719122,0.04702945,-0.022782806,0.1556671,0.0365188,1.9689266e-33,0.10104268,0.06697956,0.055235323,-0.047616616,0.004259166,-0.011067667,-0.07127007,-0.033075057,-0.009958653,-0.020791875,0.0003838957,-0.03933073,0.015569407,0.12189435,0.029459437,0.090434216,0.012323673,-0.0066243527,0.05558992,-0.0064249374,0.03632824,0.0585272,-0.05709715,-0.021793561,-0.011094359,-0.0643771,-0.08432342,0.054901946,-0.041669182,0.002292657,0.04147974,-0.024439378,-0.025214361,0.05963342,0.04115101,0.027438996,-0.049728673,-0.04141816,0.081959724,-0.03416966,-0.0021586916,0.0968238,0.003108274,0.049747247,-0.029564405,0.021036208,-0.053803384,0.03897119,-0.04534787,0.073230274,0.018797617,-0.002686551,-0.04112467,0.04715337,0.004484961,0.058938593,-0.021406732,0.0047805416,0.011886059,-0.025470916,-0.054215983,-0.004275797,0.015068893,-0.10324797,-0.012278597,0.047135808,-0.06306284,-0.03823646,0.042176943,-0.01576295,0.00270293,0.019965123,0.032435525,0.09965719,-0.00787067,-0.044701852,0.018576102,-0.00020386465,0.05832196,-0.035958376,0.0051366934,-0.035534948,0.0013177335,-0.00040176194,-0.112690054,-0.017798644,0.05102426,-0.09671963,0.03510815,-0.032853294,0.060367387,-0.044779398,-0.015727043,-0.017489353,-0.004457374,-2.8673714e-33,0.06696337,-0.078696795,0.021004094,0.01674276,-0.04623518,0.071748905,-0.007396393,-0.051238332,0.068752505,-0.04141967,0.038479418,0.083984785,0.017528953,-0.039639737,0.07557353,-0.035975322,-0.020932585,0.0651951,0.016555052,-0.02156105,0.004193678,-0.047614597,0.0019435199,0.0010883085,0.078141324,0.025565276,-0.007512881,-0.032635264,-0.04651841,0.10346818,-0.012887144,0.066404924,-0.05378422,-0.06980878,0.0678827,0.03244617,-0.059758637,0.060446892,-0.08195912,-0.037294555,0.019322298,0.04508314,0.048785124,0.10930216,0.054975692,0.05845078,0.0145845665,-0.02922495,-0.035009895,-0.034560412,0.0076945946,0.011933678,-0.022308916,0.024842031,0.06535225,0.10850473,0.058913257,-0.041165255,0.021906434,-0.082970314,-0.06943773,0.0056938617,-0.025492981,-0.06092706,0.05212401,-0.00605563,-0.0050170063,0.056023628,0.06930395,-0.06605631,-0.002755733,-0.051133484,0.10048203,0.071262,0.066376165,-0.04819348,-0.047568478,-0.07138232,-0.06765076,0.010397578,-0.048812687,0.010895611,-0.024503531,-0.024397489,-0.042684454,0.009027579,0.057360485,0.0100374995,0.023505904,0.063487634,0.035839617,0.024671895,-0.036806736,0.023766212,0.08612581,-2.8008722e-08,0.14210571,-0.023775134,0.02784857,-0.03259777,-0.08625745,0.0014689801,-0.013751176,-0.003673902,0.014425424,0.06529951,0.026959302,0.13767576,0.0076884087,-0.041600525,-0.03916046,0.07300846,-0.023717463,-0.010670558,-0.062499657,-0.003216628,-0.09504714,0.03739224,-0.01851568,0.006924647,0.035171192,-0.10781588,-0.009131987,0.021250932,-0.010586821,0.0016680025,-0.0042289356,0.010374904,0.0020527584,-0.05447191,0.004797593,0.0076691452,0.0056288852,0.013336715,0.03342845,-0.028059643,-0.03059024,-0.0368172,0.005102591,0.012712122,0.01866851,0.009630134,0.017424842,0.0014896485,-0.040615074,0.027521763,-0.06902191,-0.027047984,0.013664629,-0.088558726,-0.18704462,0.0033463945,-0.053825963,0.025988666,0.065639846,-0.044986546,-0.08614077,0.0052367644,0.0572078,0.004375214 +2.3.1.45,"The enzyme, found in animals, is essential for the formation of acetylated sialoglycans. The acetyl group has been shown to spontaneously move between the 9-O, 8-O, and 7-O positions of the neuraminate, with 9-O acetylation being most favoured.",384,1.0,-0.086978,-0.10842434,-0.046053827,0.018990431,-0.002281309,-0.029903824,-0.025945166,0.016926512,0.057388104,0.032692503,0.06808296,0.05147503,-0.047762096,0.015802948,-0.10754442,0.020820236,-0.11032937,-0.04709574,-0.02023827,-0.06678308,0.089984715,-0.031086178,-0.03745445,-0.07676993,0.036431458,-0.051757954,0.0320509,-0.037500557,-0.03447528,-0.14234564,-0.082613036,-0.06299682,0.023692405,-0.023473118,0.041763812,0.046511028,-0.024015952,-0.035156984,0.023605324,0.034651022,0.032961715,-0.075644776,-0.055273764,-0.028954063,0.03885639,-0.10936028,-0.019967193,0.00065988593,0.059676997,0.03989525,-0.09482685,-0.044933096,-0.028294815,0.04376047,-0.008080469,0.021547679,-0.06331755,-0.021761533,0.042553034,0.023393849,0.111002766,0.028835373,-0.02743752,-0.022599973,-0.035179365,-0.043890394,0.1208244,-0.04889163,-0.022394158,0.12040977,0.0067014634,0.013153376,0.008511875,0.057252146,0.07800281,-0.016820656,-0.04869443,-0.027793953,0.0816009,0.0047906134,0.04471605,0.050067693,0.01599737,0.059695378,0.036508627,0.043046396,-0.016709877,0.0021795342,-0.01606659,-0.012747849,-0.005867183,-0.05261184,-0.07018571,-0.13051535,0.04487435,-0.02130675,0.09503553,0.0042823367,0.04617559,-0.0015332771,0.035442892,0.018417893,0.0061941165,-0.02382211,-0.011849031,0.022120109,-0.014306007,0.08699135,0.066764206,0.078369945,-0.016900998,0.015994992,0.06313777,0.022483466,-0.07978747,0.06322181,-0.032606002,-0.046210293,-0.03300829,0.0043807123,0.014558197,0.009143664,0.014674126,0.06259819,0.016815413,0.11362509,-0.04003891,-2.0832985e-33,0.087028995,0.054485813,-0.036354166,-0.010690967,0.002956636,-0.05034793,-0.09462899,-0.011992735,-0.06438764,-0.04811391,-0.05541964,-0.08075846,-0.0014461201,0.08073138,0.009286145,0.07552817,-0.021546867,-0.052760087,0.016943013,-0.06748858,-0.017548205,0.09131082,-0.011248288,-0.005811995,-0.03317369,-0.0027805273,-0.10674115,0.025968026,-0.0037678545,0.0108276745,-0.0026473016,-0.0566153,-0.050914675,0.0013189743,0.07802733,0.014823524,0.060952928,-0.07516496,0.08913367,-0.0064422744,0.112330206,0.061620124,0.059579253,-0.024035573,0.05336569,0.00064999907,-0.04637128,0.09868074,0.028929992,0.0045532794,0.05030228,0.008344132,0.05205546,-0.013518691,-0.059604272,0.037212096,-0.026514873,-0.044793878,0.020008087,0.04991045,0.05925739,-0.031910636,0.056097724,0.04160003,-0.041767344,-0.0032981536,-0.07433732,0.031056115,0.019473432,0.00971105,-0.014484594,-0.027095655,0.0028604986,0.00012611492,-0.027758598,-0.00033468922,0.011770793,0.043214962,0.031801358,-0.03906367,0.06489909,-0.027105978,-0.060954403,0.015966306,-0.07076627,0.02147902,0.026735362,-0.052568913,0.006239876,0.09080917,0.019619249,-0.04636477,-0.08721182,-0.013469858,-0.027531672,-5.636464e-34,0.06767411,-0.074777916,0.08223385,-0.013311491,-0.10074617,0.09948083,0.037503544,-0.031731833,0.010593963,-0.026176626,0.05161005,0.043769162,0.036685772,-0.10732565,0.04594976,-0.007878204,-0.03407193,0.053480085,0.04545079,-0.055889413,-0.032319788,0.012390186,0.013505858,0.034065135,0.07341776,0.029430497,-0.07406514,0.009746146,-0.05751389,0.09852028,0.0076407585,-0.030122666,-0.04412516,-0.049922414,-0.04550775,0.034219556,-0.038824327,0.016563015,0.023547167,-0.008477218,0.02172039,0.0045491233,0.018528804,0.04777052,0.048109613,0.105947986,0.010730073,0.0123378895,-0.029363634,-0.012068381,0.09917229,0.015357708,-0.038605336,-0.020356365,0.002810603,0.14607882,-0.032849077,0.008396486,-0.042707607,-0.040745884,-0.10192304,0.028646287,0.0040780785,-0.077273466,0.068064876,0.025105657,-0.01045539,0.05758289,0.020905467,-0.106403224,0.017868385,0.03767911,0.0021714275,0.03316777,-0.011559924,-0.035415553,-0.07404224,-0.03509414,-0.04866317,-0.009067234,-0.094344504,0.04000705,-0.008150856,-0.049659904,-0.10562587,0.03860631,0.02595835,0.0881063,0.037701905,0.04198997,-0.017266238,0.0038753874,-0.08377996,-0.0414295,0.016531209,-3.811213e-08,0.059605267,0.020797916,0.060047265,-0.080070764,-0.038255986,-0.060559455,0.03980074,0.068779334,0.06276342,0.012345967,-0.03353766,0.104786955,-0.003695929,-0.021047575,-0.010097806,0.029384447,0.048567593,0.038594212,-0.060550764,-0.056569338,-0.10819317,0.033415556,-0.017778344,0.06286911,-0.02029926,-0.07052828,-0.01222524,0.06066194,-0.04759709,-0.0138022555,-0.018785855,0.021317692,-0.056703642,-0.058196917,-0.040301748,0.03339717,-0.013525671,-0.018664014,0.053609956,-0.038237356,-0.0062615867,-0.00041873212,-0.068234675,0.017120134,-0.056711763,-0.021406416,-0.034360446,0.011611962,0.033625994,-0.0055651003,-0.016133808,-0.007229268,-0.026387757,-0.03762582,-0.09563416,-0.06976465,-0.022238387,-0.024587184,0.050201397,-0.020139936,0.030589307,0.062124096,0.12472809,-0.014011011 +2.3.1.47,"A pyridoxal-phosphate protein. The enzyme catalyses the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis. Pimeloyl-CoA can be used with lower efficiency [5].",384,1.0,-0.1129645,-0.02884414,-0.053951494,-0.053195115,0.049230315,0.099827155,-0.051614497,0.019448387,0.06775014,0.028472302,0.0015178156,0.031995606,-0.11249093,-0.00014978541,-0.038895853,0.037153408,-0.12726274,0.035171054,-0.0027327265,-0.0847881,0.098931395,-0.018924385,-0.018627953,0.011435036,0.03094736,0.043470357,0.029823732,-0.0021447414,0.021895362,-0.07464443,0.0002609525,-0.0020229183,-0.013143485,-0.026570031,0.011606656,0.10560411,-0.058685537,-0.09320474,0.05016999,-0.0077405074,0.10010021,-0.03979561,-0.050321855,-0.039701555,-0.05066473,-0.06258697,-0.029140329,-0.017828036,0.04401761,-0.027630093,-0.080494985,0.04660234,-0.018084995,-0.08280979,0.02982185,0.0027322315,0.030889101,-0.030908998,-0.06313543,-0.02713204,0.059990242,-0.025286844,-0.066705465,-0.03017217,-0.035813615,-0.056978427,-0.028283915,-0.018929878,0.033096295,0.011180743,-0.05756725,-0.06884345,0.014935738,-0.010747648,-0.0052702446,0.0821604,-0.045937736,-0.009995657,-0.076369844,0.05282938,0.05173756,-0.002960054,0.009909572,0.062177785,0.030802306,-0.023699602,0.023283014,0.02210244,0.031411,0.0559937,0.014103538,0.030179987,0.07715808,0.029346367,-0.026499106,0.023694927,0.023360431,-0.0589394,-0.035284333,-0.041661832,-0.0133743575,0.029422026,-0.0024002367,-0.10406405,-0.042634483,-0.03478912,-0.058260173,0.07041839,0.06060042,-0.016073639,-0.042036902,0.02139987,0.016852101,0.03946832,-0.04410669,0.11442179,-0.045734495,-0.052971557,0.0037150916,0.024547096,0.02356617,0.015346684,0.000629831,0.11856869,-0.015306655,-0.04849501,-0.15529001,1.7423728e-33,0.108400114,0.062098842,0.014123114,0.03871865,-0.027760783,-0.01648325,-0.11481605,-0.03937848,0.015394748,-0.040236324,0.0026622638,-0.0071577854,0.029921258,0.004251758,-0.017471567,-0.09293667,-0.030243272,0.024632033,0.06994721,0.030713186,0.013748812,0.032999843,-0.0636576,0.043145195,0.015310385,0.023365205,0.014722676,0.028737195,0.030438138,0.00018705538,-0.022307998,-0.10062467,-0.035676815,-0.002281391,0.07934306,-0.06690735,-0.052900612,-0.05104646,0.0036807666,0.1415655,0.04134973,-0.06901532,-0.004362145,0.0072648292,0.026547765,-0.02594998,-0.04097911,0.06496683,-0.007200494,0.075320244,0.05293795,-0.03675069,0.057310116,0.012895032,-0.094901904,0.0020941428,-0.104671665,-0.0437736,0.023555418,0.012548116,0.07371923,-0.062820755,0.00013607297,-0.005911062,0.014706259,-0.02686687,-0.045929756,-0.019395115,-0.013628675,0.13153729,-0.018675638,0.0005634308,0.10075547,0.026418218,0.06943085,-0.036805317,-0.078143425,0.067929804,-0.02344226,0.0676864,-0.004645053,0.064571984,-0.06384624,-0.028874578,-0.060344428,-0.017437397,0.022641595,-0.004202977,0.02441827,0.000997294,-0.012312208,-0.08839207,-0.008128844,0.055707376,-0.032199033,-3.7733064e-33,0.101364605,-0.13178772,0.068387605,-0.04284648,-0.04278999,-0.015872145,0.11247588,-0.042318147,0.014704626,0.006267827,0.034176905,-0.009010699,0.05813716,-0.028185382,0.0065587005,0.022311226,0.008723524,-0.03761774,0.02383309,0.04023245,-0.050439622,0.0057816147,0.04201041,0.03714111,0.0475766,0.031103238,-0.040264755,0.027001353,-0.022188572,0.021635372,-0.022836141,0.033405446,-0.026521515,-0.061185963,-0.084271334,0.0887237,-0.040579405,0.024154756,0.013007939,0.0042445823,-0.006149878,-0.018616496,-0.011158998,-0.0009505646,0.05747719,-0.027233396,-0.042770766,-0.050805908,0.008476891,-0.045805853,0.04603057,0.10322747,-0.005959498,0.004818449,-0.00681042,0.062439002,-0.005187718,0.0024483735,0.06927067,0.023218296,-0.0032156408,-0.07627941,0.050700057,0.04247295,0.0053655184,0.080931485,0.04319717,0.04617407,0.038362365,-0.0034219413,0.11959813,0.08527017,0.10854369,0.1476632,0.01839904,-0.023735072,-0.023151403,-0.029791368,-0.06586816,-0.039252743,-0.07609005,-0.033611532,-0.0707367,-0.11152525,-0.07981407,-0.032975443,0.073949456,0.049701292,-0.035617877,0.008054898,0.006207432,-0.05533997,0.030545985,0.11722186,0.027509453,-3.965972e-08,0.0055022845,-0.08232174,0.00983547,-0.024388524,0.0003493983,0.052513156,0.010227531,-0.030792618,0.055879258,-0.07476447,-0.0374445,-0.00022695812,-0.043729417,0.06963589,0.046066612,0.0701052,-0.057281345,0.021796312,0.03318692,-0.045095414,-0.06959768,0.04008477,-0.11500829,0.030938301,0.027735155,0.016203655,0.011008737,0.03569856,0.016598795,-0.0267368,0.012564808,0.046631645,0.047948867,-0.03597005,-0.025464825,0.01789809,-0.016067486,-0.040545963,-0.007195958,0.014044004,-0.016758723,0.0166777,-0.049034756,-0.006912028,0.005775336,-0.008204271,-0.0029936647,0.03537853,0.001661678,0.019382354,0.085066706,0.02052306,-0.06685848,-0.054920282,-0.041075133,0.0006713118,0.027586803,-0.07183759,-0.043053664,-0.052381653,-0.058884606,-0.021087697,0.12929513,-0.06177369 +2.3.1.48,"A group of enzymes acetylating histones. Several of the enzymes can also acetylate lysines in other proteins [3,4].",384,1.0,0.009379579,-0.08735191,-0.08639273,-0.062335867,0.062386874,0.081496455,-0.054646395,-0.027676402,-0.070514336,-0.012272095,0.055491336,-0.024022337,-0.051490277,0.017192353,0.045419082,0.08588666,-0.092104286,0.004766389,-0.08215762,-0.097300515,0.058334757,0.018584507,-0.02989311,-0.055427715,0.062645845,-0.02245522,-0.0058194543,-0.021185586,0.0265299,-0.10407826,0.004312304,-0.057551082,0.030791357,-0.003156683,0.09084098,0.062026735,-0.08753447,-0.011171724,0.070631705,-0.0007716076,0.017178202,0.02014075,-0.045642335,-0.020279499,-0.03521613,-0.009601372,-0.050438065,-0.03532694,0.024627928,-0.006755192,-0.046110973,-0.013570968,-0.021239461,0.024643159,-0.12825325,9.368152e-05,-0.072642826,-0.03483309,0.035256796,-0.02138572,0.030640718,-0.0071180295,0.002015688,0.008226767,0.03256273,-0.08341349,0.07558376,-0.04353818,0.050368056,-0.027639497,0.02571228,-0.110299245,-0.023896165,0.115611695,0.07220158,-0.032685723,-0.06705524,-0.028075257,0.009332967,-0.024664413,0.0018054881,-0.023448834,0.062904604,0.082818285,0.029772574,-0.026088646,-0.04560672,0.036204513,-0.0130084995,0.018395994,0.0050219595,-0.11439656,-0.018734964,-0.01353529,0.01655006,-0.0019071219,0.08802397,-0.025428388,0.0066606845,-0.005382068,0.053449016,0.021131523,-0.0068299067,0.025399767,-0.031822126,0.029370293,0.023712013,0.031435054,-0.035403226,-0.009102392,0.014352056,-0.00868411,0.06878494,-0.0527845,0.03849717,0.07324223,-0.039248247,-0.002354187,0.045087587,0.027972165,0.049415722,0.09238183,0.103502534,0.07753392,0.0027492465,0.056379825,-0.12712196,-2.7656475e-34,0.036203433,0.09511801,-0.016676867,-0.008435542,-0.009473805,-0.046030175,-0.11629086,0.026689945,0.074315384,-0.020820389,-0.04058143,-0.0008186441,0.08749736,0.029665114,-0.036648832,0.020190427,-0.0028105332,-0.039496303,0.07545238,-0.008524909,-0.09873509,0.010996527,-0.021132052,0.055638283,0.0033476425,-0.010285629,-0.004861186,0.055398308,0.027777608,0.027457943,-0.038384505,-0.022072582,0.0047035553,0.069647,0.03555769,0.07623856,0.026514271,-0.054273725,0.01069901,0.03816274,0.070483595,-0.018820789,-0.024556566,-0.06087369,0.0056329225,-0.026596447,-0.098009855,0.043371372,-0.016695216,0.01985715,0.0387927,-0.06567796,0.07278288,-0.029319348,-0.03181733,-0.0010429547,-0.008637998,-0.0070708133,0.030452698,0.05377748,0.008563345,0.03291199,0.0338853,0.047446392,-0.00068943313,-0.030256618,-0.08692361,-0.03372789,-0.07866867,0.0031065766,-0.09074963,-0.015071581,0.091041006,0.005167794,0.033813663,-0.05163677,-0.068531014,0.04698644,-0.031120166,0.030637266,0.019287596,-0.060107786,-0.066947296,-0.007952505,-0.04618412,-0.029860405,0.048885815,-0.1244892,0.042739343,0.0063940086,-0.04436566,-0.03835996,0.014557865,0.052122947,-0.0026851199,-2.7906278e-33,0.06524843,-0.02715367,0.054236192,-0.015546736,-0.014489943,0.08727639,0.122007236,-0.023972161,0.021777354,0.018290715,0.038731612,-0.040478747,0.033131957,-0.1251074,0.0032294774,0.03225795,0.022679871,0.054608565,0.0643499,0.058628123,-0.07992333,0.035462867,-0.024634462,0.064279735,0.042228114,0.0321211,-0.08151044,-0.013233691,0.09207232,0.038427986,0.013401874,-0.0418366,0.0013204308,-0.076509885,-0.036638305,0.090146504,-0.045575306,0.0122575015,-0.046246633,-0.0013047651,0.0070281923,0.017964084,0.053313937,0.030512325,0.045785256,0.07625016,0.008793824,0.03382832,-0.082452506,-0.06895074,0.036070053,-0.02398789,-0.023140108,-0.0013732454,0.0069980733,0.1032087,0.029802227,0.03502947,-0.04696976,-0.0102811735,-0.07010134,-0.06129476,0.012354902,0.041646183,0.016012829,0.0071424604,-0.06885598,0.026157686,0.0010270155,0.020999039,0.029629784,-0.02959352,0.049476072,0.0604224,0.023782348,0.0013093078,-0.08561335,-0.09147214,-0.04545929,-0.13338365,0.012832834,-0.030442394,0.01623578,-0.031252407,-0.05582854,-0.053670857,-0.021313231,0.051955026,0.016496029,-0.0014566117,0.0038452947,-0.00014414515,-0.08006009,0.045562584,0.06820924,-2.7824376e-08,0.11485903,-0.04929069,0.07708785,-0.053296205,-0.026505303,0.023879996,0.07288432,-0.01123734,0.07054798,0.0189333,-0.06508737,0.051136944,-0.008821179,-0.058507197,-0.034496102,0.01875021,-0.05993593,0.11254303,-0.0021053073,-0.03901043,-0.036759645,0.021679575,0.0028787353,-0.023946686,-0.012640267,-0.018409269,-0.020690499,0.059057098,0.00640044,-0.032768242,0.0477303,0.019655604,0.013761589,-0.11994784,-0.073938034,-0.007059248,0.026949868,-0.094215155,0.04571046,0.007944773,0.00903102,0.030121475,-0.14904436,-0.0013445723,0.019609274,-0.04345224,-0.0025578928,-0.018624302,0.029215658,0.018087223,-0.04956658,-0.0019985798,-0.0024105285,-0.040484812,-0.029049346,-0.008397471,-0.060133625,-0.014052142,0.012696761,-0.10855066,-0.025060214,0.076994136,0.15799154,-0.0841572 +2.3.1.49,"Both this enzyme and EC 6.2.1.22, [citrate (pro-3S)-lyase] ligase, acetylate and activate EC 4.1.3.6, citrate (pro-3S)-lyase.",384,1.0,-0.025445698,-0.06703787,-0.09948725,-0.03675476,0.08253532,0.050736893,-0.04026635,0.06508954,0.021106793,-0.028529078,0.11617354,-0.07209251,-0.07724037,-0.006147548,0.052519877,0.032789648,-0.08515029,-0.016144216,-0.0055403938,-0.10909401,0.02537712,-0.0055409544,-0.03268883,0.009692731,0.060839802,-0.029371558,0.0777057,-0.033428114,-0.003697452,-0.10396073,-0.029358445,-0.057397697,0.0065069944,-0.050606914,0.011768754,0.021762706,-0.042519413,-0.12128851,-0.036627296,0.023717912,0.046609987,-0.047615882,-0.007044078,-0.07672527,-0.011899911,-0.0064237886,-0.02544447,0.037723348,0.038228184,-0.0035480272,-0.016222566,-0.11348982,0.0015186562,0.04359714,-0.026931677,0.051257312,-0.09617624,-0.018381972,0.014300484,0.06336779,0.022396956,0.05307694,-0.0043482888,0.03516876,-0.042770807,-0.07048826,0.13391887,-0.06511356,-0.010088321,-0.027684813,-0.0642388,-0.10967792,-0.017348962,0.04102589,0.028331159,0.02820438,-0.021931935,-0.09812578,0.008584122,0.021584421,-0.014003779,-0.0042303684,0.02444504,0.03450285,0.0026102227,-0.0151633695,-0.059416767,0.011698789,0.003627096,0.0175046,0.071369864,-0.033266623,-0.04591828,0.005174295,-0.044677142,0.078255735,0.0005457875,0.03444566,0.028350547,-0.004229026,-0.00620084,0.09044308,-0.05741614,-0.08657227,-0.026308943,0.050775502,-0.013417188,0.10059053,4.125982e-05,0.030618424,0.026607474,-0.093457036,0.022444382,-0.044837065,-0.06231989,0.13357364,-0.017021168,-0.054957926,0.07568372,0.08159948,0.06201688,-0.006739244,0.023496283,0.034364354,-0.0584838,0.047099754,-0.05354006,2.854823e-35,0.035219073,0.029108396,0.007812938,0.03135008,0.011379577,0.020060219,-0.096300334,0.026029184,-0.0765759,-0.10908839,-0.103319466,-0.051208686,0.005725185,-0.0022597767,0.038195282,-0.017557675,0.035273854,-0.03276493,0.043997508,0.054652322,0.07146762,0.03739026,-0.055943012,0.030148894,0.05731769,0.040426955,0.03837689,0.04237682,0.0043147625,0.014608349,-0.031277157,-0.034459654,-0.031113865,0.0021579147,-0.015832802,0.04446227,-0.020762373,-0.06999557,-0.059827037,0.06411242,0.09438305,0.057733007,0.008018515,-0.05383472,0.05786514,-0.069240026,-0.038579043,0.0799495,0.07471156,0.079937816,0.04878076,-0.04181237,0.06477374,-0.0087752035,-0.03048253,0.025009144,-0.08973086,0.048702445,0.04272198,0.012544146,-0.026848841,0.006635559,-0.00895039,0.024426203,-0.0016646784,0.068035685,-0.09030874,-0.04688658,-0.025223257,-0.0035659343,-0.1457213,0.009061489,0.10602791,0.016693277,0.042804107,-0.1031146,-0.11741615,0.022081159,-0.006991408,0.040411923,-0.0100016035,0.039281197,0.0077629345,0.07179609,0.029581446,-0.065070644,-0.041383605,0.03061735,0.020489154,0.014094156,0.046224244,0.010334652,-0.030703574,0.09573997,0.0030042662,-2.5856738e-33,0.051643398,-0.08822673,0.0573357,-0.014307577,-0.015059146,0.11990385,0.061704658,-0.049149033,0.002414494,-0.024631241,0.1253862,-0.024744,-0.030223599,-0.10623182,0.011895407,-0.028510325,-0.06601575,0.030574288,0.024676876,0.069437526,-0.010897374,-0.0037694587,0.03730903,0.01860572,0.08717017,-0.023386799,0.03727883,0.030576462,0.040262688,0.030958625,-0.013398027,-0.023771306,-0.031480476,-0.0111284265,-0.114854746,0.039968833,-0.035936236,-0.0018850308,0.036806684,0.011642007,0.02377095,0.056063265,0.005596805,0.07079212,-0.03891759,0.065212086,0.0038728912,-0.011951128,0.01730436,-0.073360376,-0.009784084,-0.036103435,-0.0673274,0.03156735,-0.00031891422,0.030078309,0.017520523,0.015981415,-0.04463595,0.0016904162,-0.063875705,-0.027946053,0.028183045,-0.008255843,0.08906436,0.024336921,-0.03247213,0.071641065,0.048077732,-0.029383542,0.06739355,0.026983665,-0.014436108,-0.04021805,0.013964304,-0.093726784,-0.096636765,-0.039845575,-0.008439533,-0.04860202,0.026707884,-0.05625144,-0.03950938,-0.017471954,0.040773135,-0.021879638,0.009505195,0.07026958,-0.012766871,0.03536982,-0.045169376,0.026749216,-0.04094661,0.016583169,0.041352402,-3.2990624e-08,0.06603233,-0.039055753,-0.018898727,-0.072382726,0.03493518,0.032303546,-0.0266899,0.017254956,-0.019331021,-0.011538485,-0.03349012,0.047180615,0.013022327,-0.039991267,0.092738256,0.0148797,0.03876404,0.115978256,-0.0031535635,0.044928696,-0.04886108,-0.027451564,-0.044636197,-0.009416098,-0.013290187,-0.0092380615,0.06457085,0.11990596,0.024877662,-0.011812488,-0.07878457,0.00018255341,-0.020696979,-0.01942027,-0.05758953,0.009534223,-0.025705896,-0.03478463,-0.052666407,0.040285476,0.04280398,-0.05287501,-0.10060151,0.0032015357,0.004818453,-0.02709674,0.08260195,0.021630973,-0.053612154,-0.050328106,0.012083568,-0.0865283,-0.013164437,-0.023295118,-0.028262231,-0.004965004,-0.01620827,-0.07096748,-0.0123397065,-0.04740927,0.063640624,-0.0014446541,0.1492741,-0.0014605352 +2.3.1.50,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.3.1.51,Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.,384,1.0,-0.08728335,-0.061209626,-0.042195544,0.06605031,0.023214763,0.058656167,0.009416765,0.021567117,-0.011095409,-0.07358038,0.09293465,-0.059929393,-0.08680298,0.08576756,0.033837985,0.0614867,0.009903309,0.0061878273,-0.051419023,-0.08372293,-0.01932024,0.001746448,-0.014215215,-0.04778637,0.028091922,-0.13092327,-0.06259625,-0.06736863,0.0054451674,-0.04184603,-0.050866913,-0.06173694,-0.068586186,0.019258348,0.026068453,0.008968326,-0.01639009,-0.047979083,0.055726245,0.0063669295,0.046477538,-0.05262325,-0.003535918,0.04615445,-0.047666557,-0.02644151,-0.0075261565,0.039309837,0.029652024,0.0031211649,-0.017859528,-0.013960575,-0.050276704,0.051300928,-0.06814062,0.11138753,-0.008207732,-0.07349348,-0.082316324,-0.04451816,-0.006128983,0.032183077,-0.0109550385,0.021576514,-0.0515707,-0.10572441,0.026883163,-0.0132061,0.0767812,-0.042301044,0.04655018,-0.11851093,0.035154756,0.013098092,0.10422437,-0.005076325,-0.0396626,-0.030609565,0.068713956,0.045262977,0.020982156,-0.019616937,0.054217655,-0.0065146317,0.07871155,-0.0528424,-0.016996821,0.03080787,-0.1012605,0.006344907,-0.0054165754,-0.0380003,0.025743583,-0.015157403,-0.09914851,0.016683992,0.066118196,-0.04448627,0.009995656,0.013256031,-0.018871496,0.026473459,0.030278437,-0.078117244,-0.07652333,-0.0018145654,-0.032402404,0.009858526,-0.036941808,-0.012305787,-0.050625887,-0.012651658,0.0796355,0.025559604,0.03227281,0.08406057,-0.12824036,-0.051571798,0.007674649,-0.046386283,-0.05516201,-0.0040563922,0.010249729,0.07996054,0.009072235,0.027643757,-0.10397648,-1.0548798e-33,0.018559195,0.017268108,-0.024057176,0.0044753985,-0.024186196,-0.049902495,-0.069377415,0.03914179,-0.020334376,-0.012304246,-0.000844532,-0.09564631,0.056403745,0.08385722,-0.022927519,-0.033371214,-0.016504692,0.030139843,0.11739158,0.034521732,-0.0036629492,0.12761389,0.028160669,-0.024533981,0.048674896,-0.014970445,-0.07667593,-0.006812623,0.0053898315,0.028518839,-0.04924948,-0.053824864,-0.01887881,0.020536298,-0.0006511742,0.0059118285,0.038485777,-0.09751503,-0.026018813,0.018394891,0.07021483,0.013454782,-0.009270595,-0.02879055,0.05460773,-0.018293932,-0.1041259,-0.013082578,-0.04822938,0.045096662,0.048841737,-0.04726727,0.070595495,-0.02543738,-0.0681244,0.006708235,-0.05103517,0.027341234,0.021051625,-0.06055277,-0.0034055843,0.00970724,-0.0062242323,-0.023621622,-0.003330465,0.005169002,-0.04081513,-0.041050598,-0.091986656,0.100660175,-0.022705268,0.0015397634,-0.0071766786,0.0031191788,0.06608471,-0.038686816,-0.058808412,0.089786015,0.028874565,0.021346863,-0.023299042,0.002062347,0.050984267,-0.02086217,-0.034030218,-0.06370475,-0.018381108,-0.020077549,0.07139709,-0.06847728,0.060239222,0.012708785,-0.052676514,0.03099773,0.09382846,-1.5220512e-33,0.114063725,-0.096541,0.03076429,-0.046620846,-0.04154615,0.06102395,0.07178634,0.026275998,0.11016488,0.042547498,0.022393988,0.013521326,0.017497258,-0.10358438,0.05003627,0.00406968,-0.082209975,-0.019716997,0.020615123,-0.008307133,-0.07084325,0.005636805,0.043058366,0.04761948,0.0013980038,0.034716703,-0.0884702,0.06178126,0.0651324,-0.01145783,0.044274405,-0.028185742,-0.019628914,-0.067178994,-0.020596184,0.05122744,-0.023652164,0.041463148,-0.046238475,0.060145013,0.07213718,0.008751712,0.029581945,0.036788277,0.023420116,0.022234906,0.008331368,-0.07159435,0.07979981,-0.11851424,0.06403824,-0.020906368,0.062482692,-0.051090147,0.041298203,0.16560498,0.072813414,-0.03903972,0.046041314,-0.09643574,-0.06369085,-0.017672276,0.038084332,-0.007459255,-0.02307501,-0.0143907685,-0.0023383447,-0.044706743,-0.0064384704,0.003612994,0.053357355,0.10765918,-0.043168716,0.053000733,0.009702262,-0.05738063,-0.022822825,-0.013015551,-0.017825302,-0.005171448,-0.032118842,-0.07257412,0.017084017,0.017121186,0.059629526,0.012280396,-0.03173045,0.026083088,0.04167182,-0.011996689,-0.0014191157,0.013327994,0.003916656,0.0002518152,0.016559275,-2.835209e-08,0.051112875,0.017351352,0.02407299,-0.0032458801,-0.066746265,0.018471828,-0.047065124,-0.06206623,0.020486547,0.01514784,-0.08776249,0.09327727,0.024956018,0.08026545,-0.037542056,0.011657242,-0.011196058,-0.0057148053,0.016387152,-0.0614093,-0.09061346,-0.0095474785,0.0027448805,0.071940854,-0.023564376,0.026555607,0.04165586,0.037770648,0.00792228,-0.048653476,-0.020467594,0.011628244,-0.0450975,0.059844628,0.07871357,0.040332094,0.0653065,-0.10162268,-0.0415811,0.05469243,0.044976156,0.061453916,-0.06263439,0.022501823,0.08338044,-0.019523498,0.018159354,-0.04052277,-0.028972194,0.024225302,0.040453043,-0.023763055,-0.09050891,-0.02637801,-0.063088454,-0.015020083,-0.07355361,-0.036301743,0.045464486,-0.03713808,0.023017487,0.044632193,0.16392532,-0.027747653 +2.3.1.52,Saturated acyl-CoA thioesters are the most effective acyl donors.,384,1.0,-0.09457332,-0.03231342,-0.042708974,-0.0088171335,0.023423681,0.031165656,-0.028305396,0.101660356,-0.05743378,-0.019846516,0.01863168,-0.05342896,-0.09263221,0.033499144,-0.0101566315,0.1013955,0.07345958,0.010199514,-0.021745918,-0.061463915,-0.061835222,0.036410235,-0.009940509,-0.027445024,0.047754,-0.04838963,-0.07267191,-0.04435553,0.020968817,-0.05401812,-0.031428453,-0.0140007995,-0.009849091,-0.016701212,0.045697328,-0.009386571,-0.06392547,-0.045229487,0.053922515,0.038284276,0.04460105,-0.04886211,0.023518737,0.040397428,-0.11886361,-0.10748357,0.047733422,0.07917192,0.025251033,0.049328912,-0.0064497055,0.019280784,-0.04185387,0.081770204,-0.09738208,0.047628384,-0.01880667,-0.022042293,-0.0697689,-0.043425243,0.0047285846,0.030931389,-0.054370396,0.022856941,-0.042157345,0.009147486,0.07333692,0.042950887,0.110271946,0.005182073,0.00871122,0.00047020585,0.012351318,0.04311804,0.08919175,0.04904786,0.041279223,-0.09665994,0.06123892,0.0384843,-0.04203472,0.021739408,0.07809766,0.0076580006,0.08125644,-0.025158508,-0.021195598,0.03357282,-0.046731178,-0.007999398,0.07545814,0.0462485,0.017695613,-0.011037212,-0.110658824,0.05632491,0.086993486,-0.01932693,0.028120633,-0.014810177,-0.010216194,0.030219447,0.0007702922,-0.09177422,-0.05220318,-0.041668754,-0.023023851,-0.011529776,0.009000757,0.0023199343,-0.016144628,-0.019760508,0.05597469,0.008901669,-0.026650682,0.05695885,-0.060083583,-0.02504022,-0.0039543565,-0.005050184,-0.025415927,0.021909067,0.025934676,0.0785627,0.015105375,-0.0189536,-0.076361775,-9.642486e-35,0.012932044,0.08517048,0.032887187,0.027257023,-0.039801743,-0.034149468,-0.09818354,0.01060733,-0.056933623,0.021067558,-0.031172836,-0.07895476,-0.00021426796,0.04907454,-0.045617208,-0.08761972,-0.035194803,0.004643677,0.006664784,0.023266375,0.0144015895,0.076442055,0.024000335,0.04684907,0.04354446,-0.040588975,0.034062453,0.14624782,-0.010898204,0.032310877,0.010587866,-0.023057135,0.03468957,-0.017788814,-0.0737025,0.003092227,-0.08689327,-0.027010493,-0.02350487,0.06538813,0.068478905,0.10199042,0.032030523,-0.041246757,0.09012711,-0.07414893,-0.0799395,0.050240524,-0.020867512,0.015029362,0.026432198,-0.033471398,0.031852443,0.02147734,-0.05129698,0.0063912375,-0.034393866,0.04996221,0.029623302,-0.054856423,0.036719415,0.0010311293,0.0042218016,-0.01686971,-0.068667404,0.030478436,-0.014054571,0.0129106585,-0.061681785,0.036411963,-0.014114014,-0.005449003,0.041010723,0.004916951,0.057567876,-0.036305096,0.012157367,0.084332444,0.060700376,-0.019193187,0.014770487,-0.004010748,0.033988286,0.016407963,-0.029249687,-0.08406228,-0.035856556,0.04134619,0.07230813,-0.02879814,0.05021712,-0.025745884,0.03171156,-0.090288885,0.018964704,-7.173468e-36,0.14763653,-0.089577146,0.03712661,0.003452435,0.001311744,0.01914149,0.0067411647,-0.028495725,0.117508076,0.032235194,0.11794929,0.0573357,0.0184026,-0.11511117,0.062124364,0.03651875,0.047179814,-0.044461884,-0.0010906666,-0.04066709,-0.061954964,-0.013942916,0.044749312,-0.056712657,-0.013628934,-0.0041215597,-0.09573694,-0.018858667,0.05195046,0.02669801,0.025336092,-0.008588105,-0.07873313,-0.056786485,-0.054758273,0.03403671,-0.0051525612,0.030224824,-0.022797413,0.0902508,0.039639708,-0.055320136,0.025139408,0.033169672,-0.037189912,-0.019130709,-0.043860022,-0.14227591,0.077879794,-0.09515382,0.0083128745,-0.027175633,-0.015111452,-0.013565292,0.020193882,0.116099805,0.041560322,-0.043022726,0.024127627,-0.08505856,-0.07356059,0.030775588,0.00843412,-0.027570426,-0.02335851,-0.004177623,-0.0559913,0.082123235,-0.02751057,0.0041126017,0.073447496,0.09868865,-0.015347539,0.00339064,-0.01454751,-0.03608803,0.007892274,-0.026767405,-0.0336347,-0.009872169,-0.051151365,-0.08861078,-0.057473324,0.03786366,0.034819625,-0.0070076766,-0.014355577,-0.048980284,0.010419478,0.035415724,-0.039663352,-0.051577494,0.08106499,0.06451024,0.06171218,-2.0233406e-08,0.018962163,-0.010269061,-0.060832825,0.023458553,-0.04749639,0.017595097,-0.06450874,0.0213422,0.025564773,-0.01880723,-0.04293404,0.109548666,0.074542046,0.03455335,0.012300086,-0.043268315,-0.038719367,-0.042101037,-0.03731285,-0.08671176,-0.07628885,0.023855684,0.040723495,0.03282352,-0.025628138,0.07478271,0.08247433,-0.07123943,-0.018264776,0.037473317,-0.037264287,-0.0012001166,-0.081677124,0.032177273,0.09561463,0.057227924,0.03710683,-0.047129605,-0.07882671,0.07090787,0.04473822,-0.03214787,-0.09082203,0.06566607,0.09126461,-0.0678733,0.032875966,0.084392026,-0.036204565,-0.0086397715,0.0013550005,-0.022744112,-0.08912188,-0.008514343,0.0014126614,0.029521938,-0.010439343,-0.00923489,0.024038855,-0.036249127,0.010176422,-0.0118420785,0.12471923,-0.03490038 +2.3.1.53,"Also acts, more slowly, on L-histidine and L-alanine.",384,1.0,0.07381053,-0.1696997,-0.042046536,-0.008762331,0.07519452,0.045934115,-0.024764786,0.06268046,0.04847476,0.016195282,0.03609202,0.027379602,-0.019075593,0.11414572,0.021845162,0.0009943013,-0.030895786,-0.025149858,-0.06720803,-0.02622338,0.0023777036,0.01614783,0.013528859,-0.031468946,-0.005852896,0.01679098,-0.016762564,0.015734011,0.03391911,-0.09037033,0.009458064,-0.013455217,0.07485258,-0.03744574,-0.015173301,0.050883356,-0.05891754,0.010930267,0.039045084,0.025815997,0.056709666,-0.032900468,-0.021967912,-0.025419353,-0.018879468,-0.016785694,-0.03787407,-0.037054405,0.018977731,0.09128148,-0.04167115,-0.08225302,-0.023178693,-0.005053952,-0.07550727,-0.00593286,-0.16083984,0.03173396,0.0015515568,-0.0044558602,-0.07755312,0.044036496,0.022406647,0.039946176,0.041247007,0.026529338,0.07963591,-0.08172712,0.011658018,0.009682273,0.04109084,-0.033205744,-0.0056098527,0.038284462,-0.0012972396,-0.1151885,-0.0333905,-0.051552527,-0.018996555,-0.00895067,-0.06565631,-0.014175419,-0.059279513,0.019014174,-0.04352835,0.0027418626,0.0010263748,-0.06669732,-0.06478075,0.01941503,0.0639403,-0.037836988,-0.06002191,-0.030103056,0.033082645,-0.010917886,0.020296784,0.03277099,-0.060896385,-0.036023226,-0.025836345,0.040680666,-0.11159371,0.024464924,-0.01111352,-0.008249267,0.038931657,-0.026543053,-0.098628305,0.015157222,0.043279763,0.013477323,0.014371421,0.039433308,0.017554065,0.08157951,0.030735606,-0.0032662342,-0.04838039,-0.009155048,0.054740667,-0.049560733,0.032382455,0.028402628,0.0036664966,0.08071128,-0.014922807,-2.221342e-33,0.057236467,-0.043477602,0.020605842,-0.0062279017,0.013909902,0.014912215,-0.07721383,0.05008368,0.091160126,-0.06952958,-0.05970624,-0.051874336,0.05235549,0.0014008529,-0.07874505,-0.01768527,0.0112236375,0.005982073,0.014331693,-0.019504977,0.007899627,0.099034734,0.013017893,0.01409414,-0.005470654,-0.029366514,0.015312794,-0.0054989816,0.015964739,-0.016354762,-0.0371014,-0.020658748,-0.039252274,0.05446709,0.003072349,0.10889385,-0.06109195,-0.005507009,0.06933988,0.016073084,0.03008257,0.06390347,-0.077935144,-0.00524364,0.004161788,-0.023595324,-0.07875344,0.032734133,-0.038799226,0.040198736,0.11843658,-0.038172398,0.046644837,-0.041725263,-0.0068962392,0.06212721,0.028182622,0.006401091,-0.04529853,0.12711313,0.05621746,0.050331235,0.036633696,0.056337327,-0.001981861,0.022236655,-0.102777414,-0.07851446,-0.006915487,0.023408901,-0.06295849,-0.025585063,0.13084656,-0.007824161,0.049954534,-0.032058958,-0.08315932,0.0012896262,-0.014734402,-0.034256414,0.014886928,-0.0632017,0.020326138,0.04104428,-0.048032794,-0.04888384,0.025381986,-0.120668024,0.007682924,0.0069747097,0.015753193,-0.042222906,-0.02890366,-0.023041422,0.015275018,-6.4538584e-34,0.03823832,-0.109904245,0.049085494,0.06925328,-0.025521811,0.076220065,0.029267501,0.04205285,0.06005198,0.0013189276,0.08249117,-0.03612049,-0.105247244,-0.054674644,0.0073413276,0.015462723,0.07698555,0.07945166,0.021132184,-0.005092789,-0.056140576,0.06209167,0.07363414,0.05054377,0.044382628,0.0025611604,-0.019620553,0.0034863993,0.005403736,-0.010562922,-0.003973163,0.018704105,-0.09292818,-0.16456118,-0.026026448,0.076249346,-0.05393447,-0.002691899,-0.053126138,-0.062406752,-0.005521676,-0.043951124,0.11527275,0.06500359,0.009857019,0.033939008,-0.0050166515,-0.048139606,-0.10296598,0.02028819,0.0010442877,-0.020348776,-0.051838975,0.035771757,0.08259677,0.041325092,-0.007824167,-0.08245652,-0.051166814,0.026618512,-0.020786239,-0.008391027,-0.057948586,-0.036535632,0.05589966,-0.02191986,-0.019834245,-0.0058210627,0.120454706,-0.0031666341,0.08675786,-0.06465147,0.019953417,0.0743381,-0.09718741,-0.061140206,0.0061412426,-0.114008985,0.026705755,-0.09282275,-0.10817263,-0.010743963,-0.009246444,-0.04684521,-0.119565666,0.014377761,-0.049611263,0.030432908,-0.006102011,0.07943736,0.019064173,-0.03800525,-0.0045718844,0.0052880105,0.044793632,-2.1374392e-08,0.0492323,-0.052436803,0.054911308,0.036495324,-0.014171294,0.033479072,0.01829615,0.08933055,0.0058931513,-0.027227659,0.034775328,0.06860922,0.061754245,-0.024291396,0.041986242,0.03802276,-0.04803246,0.018270753,-0.026361419,0.023057315,-0.11358606,-0.012882759,-0.03752427,-0.044513233,-0.014697797,-0.026883932,0.0055646407,0.11517384,0.031368036,-0.056846857,0.06678358,-0.02229776,0.046767563,-0.052553166,-0.038955055,0.011568964,0.08583786,0.010996407,0.036189757,0.04073426,-0.0408927,0.0046355985,-0.06824745,0.043859392,-0.021896392,-0.05808351,0.027343966,0.0111618815,0.04546331,-0.052713476,0.054967843,0.020791983,0.0017550797,0.012386351,-0.01234036,0.06983967,-0.060709488,-0.0602601,0.07827692,-0.0058124824,0.016136667,-0.01482313,0.09341814,0.046010144 +2.3.1.56,Transfers the N-acetyl group of some aromatic acethydroxamates to the O-position of some aromatic hydroxylamines.,384,0.99999994,-0.065352686,-0.09121752,-0.061634813,-0.049631946,0.016448794,0.05366551,0.015310092,-0.041183017,0.08180578,-0.10663519,0.07723594,0.03318601,-0.027912466,-0.08462872,-0.040200144,0.058855355,-0.039485086,-0.0033365963,-0.023602653,0.0139701,0.023627186,-0.03734228,0.019720243,-0.041254003,0.00982388,0.044727348,0.003933041,0.046562195,0.04498299,-0.097290546,0.1295327,0.030117312,-0.06339626,-0.024343446,0.04091295,0.02300149,-0.028693985,-0.034672093,0.053725973,0.072430484,0.050262008,-0.046806432,-0.035187267,-0.054248486,0.029583022,-0.08399072,-0.011449346,0.02910261,0.029885195,-0.029051848,-0.019140381,-0.033491336,-0.0025380515,0.077445224,-0.029978836,0.114705116,-0.053676985,-0.04569089,-0.050027926,0.06126422,0.063166454,0.053966973,-0.0076403427,0.003574732,-0.01718914,-0.04216845,0.094505705,-0.054949597,0.024556875,0.0098209735,-0.07418759,-0.019867647,0.0026724283,0.020314839,0.01770014,-0.02384618,-0.061206214,-0.046912163,0.0034239697,-0.047860738,0.0038381328,0.007563314,-0.02505965,0.12880297,0.04235653,0.018411921,0.009391163,0.046884906,0.009566911,-0.015118905,-0.088351965,-0.0365006,0.01738701,-0.045367926,0.019665908,0.004778065,0.09709366,0.048568804,0.018388774,0.03978794,0.030476779,0.033578098,-0.04570989,-0.06401384,-0.07123338,0.03779952,0.052548844,0.022295043,-0.012656069,-0.021163393,-0.04614652,-0.040255383,0.013274204,-0.022788038,-0.100348376,-0.021782765,-0.031623065,-0.039708305,-0.007415364,-0.05534766,-0.022841683,-0.004353758,-0.015730154,0.06964351,0.0053298194,0.13260731,-0.049904004,1.6087612e-33,0.04477695,0.040956177,0.069838054,-0.020502377,-0.011399768,-0.051886886,-0.12145964,-0.058721498,0.04706111,-0.027141681,-0.020839807,-0.0042985147,-0.017772837,0.0073345783,-0.01754228,-0.06974324,-0.033940442,0.035749044,0.024648095,-0.06125083,0.007896246,0.061273824,-0.05784064,-0.005506453,-0.07751435,-0.009325895,-0.08195655,0.0025699912,-0.013254097,0.020327097,0.008797573,-0.034533884,-0.06657758,-0.0054873293,0.044381373,0.039553296,-0.0323571,-0.041855585,0.07688286,0.014079721,-0.029088631,0.057249956,0.02811425,0.012991813,-0.04000312,0.034554515,-0.12475211,0.039645325,0.03304123,0.019032523,-0.010654899,-0.072605245,0.050137356,-0.011695078,-0.022431418,0.011800485,-0.072780356,-0.031046018,0.009119572,0.0066477386,-0.050007302,-0.0407184,-0.048790585,-0.054043695,0.009267682,0.021818647,0.024900513,0.034650743,0.054751568,-0.037039947,-0.03264798,0.038284488,0.08639197,0.08658222,0.076841995,0.024377313,-0.019657476,-0.03685827,0.03490527,0.045709416,0.06291637,0.019661497,0.02723463,-0.0632555,-0.040338553,-0.0017405865,0.052991282,-0.044284906,0.02839152,0.058010027,0.027284162,-0.105239026,0.08618943,-0.028960377,0.0059312973,-3.4451605e-33,0.048219007,-0.010341978,0.06008163,-0.06180941,-0.04337521,0.03703233,0.07646042,0.008015039,0.0013715811,0.10868589,0.07148581,0.055535622,-0.03632773,-0.06260725,0.0071190954,-0.038480137,0.0030175874,0.059461184,0.08057638,0.016422192,-0.011947647,-0.020357506,0.049389116,0.14227352,0.038772687,0.046137862,-0.013505901,-0.04255115,0.017616075,0.04145335,-0.007729818,-0.030314002,-0.021432588,0.010510358,0.026802085,0.0912036,-0.055004347,0.093847275,-0.0819089,0.020323459,-0.05433399,-0.04723659,0.056336828,-0.0240776,0.0128089655,0.06028204,-0.05414302,-0.05391187,-0.11582568,-0.06346548,0.023299797,0.08231145,-0.045001853,-0.025756933,0.039422203,0.12280679,0.02982452,0.0094509255,0.016041083,-0.07065296,-0.0425651,-0.020359445,-0.024404492,-0.052261587,-0.03994627,0.035155684,-0.01750378,0.05012588,-0.0023831117,-0.03931778,-0.032039873,0.0045271884,0.11152142,0.046801634,0.049086846,-0.103642836,-0.04729106,-0.10237926,-0.08053304,-0.077489145,0.004234202,-0.010396867,-0.07520584,-0.0546595,-0.095415086,-0.0050180815,0.08027687,0.0036000928,-0.02612407,-0.032175936,0.023622176,0.058719166,-0.038242865,0.02669767,0.06032973,-2.5853025e-08,0.036531147,-0.013369048,0.12608635,-0.010571058,-0.0074072755,-0.0018368899,-0.002587288,0.04732889,0.10115741,-0.04684075,0.0082113845,0.11906653,0.11144758,0.015221196,-0.05166768,-2.5552383e-05,-0.058910377,-0.024942001,-0.017907243,-0.052334037,-0.07826242,0.080469325,-0.0256639,0.020644162,0.018021274,-0.034724556,0.018405654,0.039178044,-0.018828806,-0.015528238,0.048742242,0.009879227,-0.041473605,0.025194826,-0.016489923,0.017528143,-0.021603247,-0.0109238615,-0.0030663386,-0.031721905,-0.04578267,-0.032577354,-0.027359355,0.018499007,0.13882358,0.031241965,-0.015579278,0.034942146,-0.052800756,0.04957757,0.007941622,-0.069908,0.011171743,-0.08267561,-0.0892562,-0.07523778,-0.057503838,-0.014156529,0.031968184,-0.050300654,-0.046175417,0.04402653,0.13214804,0.027784266 +2.3.1.57,"Acts on propane-1,3-diamine, pentane-1,5-diamine, putrescine, spermidine (forming N1- and N8-acetylspermidine), spermine, N1-acetylspermidine and N8-acetylspermidine.",384,0.9999999,-0.017935477,-0.077629,-0.075351715,-0.078584984,0.08647617,0.06902484,0.04440978,0.015041935,0.019569838,0.039112173,0.009622609,-0.031783827,-0.08078785,0.11831889,0.01951664,0.034948394,-0.0015595512,-0.066144906,0.035505265,-0.032340523,0.06082981,0.03281758,-0.01248784,-0.004452766,-0.03726611,0.052684568,0.022119801,0.05480262,0.02078782,-0.0821582,-0.016532704,-0.059111938,0.04978995,-0.07539285,0.029902386,0.0154948635,-0.083155565,0.03429514,0.043110326,0.12242952,0.092994615,-0.031100761,0.005132949,-0.022517908,0.03357801,0.0061650006,0.0056534,0.03057798,0.01901557,0.047596373,0.035079278,-0.04708262,-0.03931486,0.09509223,0.0549495,-0.08032309,-0.098192036,-0.02934388,0.008736852,0.012929077,0.015085993,0.034781575,-0.019529212,-0.056726962,-0.009258905,0.031097272,0.040577885,-0.02635982,0.07964495,-0.019774102,-0.048274707,-0.016415384,0.01009144,0.04169135,-0.013374364,-0.032145713,-0.019070812,-0.02511759,0.029556293,-0.079559416,-0.10511842,-0.077182196,-0.05415633,0.025204761,0.0031932604,0.07561958,-0.046757534,0.023138879,0.074434005,0.017729793,-0.029890982,-0.04005837,0.031912003,-0.049158446,-0.062188398,-0.022516275,-0.031286243,-0.0030280633,0.0107108,0.025904914,-0.013037213,0.058549874,-0.069943555,-0.052261595,-0.07514838,0.010239128,0.03287011,-0.0059761833,-0.056766674,0.050773785,-0.082208835,-0.015815424,0.040928185,0.010716027,-0.04155691,-0.018829994,-0.010952696,-0.03125504,0.021666441,0.00072659575,0.031257823,-0.013812284,0.008552427,0.09227964,-0.044745848,0.049407303,-0.03548267,3.7101544e-33,0.05699041,0.037016757,0.018484022,0.064092286,0.048848968,0.074658856,-0.025584929,-0.019465555,0.06992638,-0.075393334,-0.026990343,-0.0026942831,0.051193535,0.031134555,-0.035986386,-0.0660963,0.023888571,-0.020089857,0.03390662,-0.053409155,-0.007423876,0.1713367,-0.0329187,0.012156775,-0.013751596,0.0012308027,-0.037082184,0.047863107,0.036122475,-0.050378088,0.02051677,-0.047612738,-0.05384655,0.0068961834,0.031036574,0.04657566,-0.044696983,-0.06539557,-0.04747013,0.0030974715,-0.032902934,0.021055764,-0.09664986,0.051593233,-0.048357584,-0.063503735,-0.11662605,0.099402234,0.03306615,-0.0005486094,0.040367726,-0.029707696,0.052095894,-0.07449646,-0.09475351,0.03654607,-0.07029285,-0.024199829,0.006969525,0.015797187,0.044524163,-0.0289743,0.02164453,-0.030369014,0.016383538,-0.019802785,-0.09346253,-0.028577767,0.065280296,0.00011112025,-0.07827545,0.02883692,0.07888447,-0.029126842,0.052426063,0.0049294117,-0.10360724,0.018589124,-0.008585167,0.00038330074,-0.022705847,-0.065424606,0.024569718,0.04636087,-0.11625909,-0.018384239,0.04088889,-0.09370291,0.0022730958,-0.0077504963,0.000825913,-0.08811273,0.024293017,-0.01280366,0.06621374,-4.0256593e-33,0.0064203595,-0.07662771,0.069364816,0.037491757,-0.009559491,0.05409704,0.027836628,-0.113478065,-0.029878188,-0.028257176,0.036526717,-0.043946274,0.04277299,-0.06503629,-0.030024227,0.022207221,0.017155902,0.06496102,0.07118358,-0.0053867237,-0.0552445,0.035920653,-0.023104953,0.08919013,0.015812464,0.036884315,0.019063707,-0.044958465,0.054523006,0.05914011,0.007890825,0.029553883,0.008830996,-0.00054839026,-0.02959916,0.05871224,0.01163602,0.030690802,-0.03597722,-0.07373064,-0.01042598,-0.030545173,0.0058622607,0.11547637,-0.058383584,0.0850914,-0.011595791,0.05996477,-0.054888535,0.030759614,0.00879977,-0.027877042,-0.09444691,-0.03310003,0.09665668,0.043663092,0.020187298,-0.0681095,0.041066673,-0.0024434356,0.0024538278,0.028650278,-0.016684705,0.038926993,0.052036744,-0.02149605,-0.06656896,0.06401521,0.10244828,-0.025652034,0.08919006,0.03287239,0.12883312,-0.026697438,-0.020079514,-0.109518126,0.0022793682,-0.06996486,-0.005298177,-0.0427243,-0.0075568184,-0.08292944,-0.04836419,0.051466357,-0.082479686,0.061089464,0.08766743,0.10203775,-0.0076498967,0.03900754,-0.0038227178,0.06695306,-0.0068911877,0.093639635,0.020418108,-3.4991036e-08,0.07689082,-0.05185752,0.061100993,-0.022676505,-0.092087224,-0.018908272,0.007946628,0.04555596,-0.004357535,-0.03995533,0.024935214,0.04219836,0.08660765,-0.05147829,0.052683283,0.031080348,6.450988e-05,0.0973573,-0.0373623,-0.010169719,-0.09098676,-0.016992247,-0.09962265,-0.041792244,0.016021414,-0.040414877,0.0040468345,0.084163636,0.06330901,-0.008110463,0.051054426,-0.024241291,0.009045071,-0.1453412,0.008443633,0.09379713,0.0021855691,-0.014406946,0.033613604,-0.0034761932,0.010554074,-0.029410366,-0.07811081,0.017744135,0.04774136,-0.06583373,-0.012777441,0.021369055,-0.059546392,-0.044284936,-0.028263383,0.017049873,0.0189017,-0.009326518,-0.027117059,0.03009946,-0.024876794,-0.037772126,0.07004422,-0.017260399,-0.0179056,0.05128938,0.0914084,0.022050874 +2.3.1.59,"The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.",384,1.0,-0.03877869,-0.051437505,-0.06897551,-0.020294618,0.002237948,0.014855335,-0.0134931095,0.021534119,0.03488639,-0.014730415,0.053208828,0.014801719,0.077587344,0.122321784,-0.04186689,0.012154142,-0.037675895,0.05318102,0.02971976,0.03807958,-0.08712908,0.071561545,0.07013544,-0.003349638,-0.007895402,-0.023643006,0.0054817684,0.06347372,-0.020488909,-0.0648415,-0.014469451,0.027295627,0.041510604,0.045267764,0.027843472,0.031717595,-0.08399609,0.032484062,0.18867092,-0.009931192,-0.028636532,-0.022853522,0.05384478,0.008645438,-0.009315327,-0.015392609,-0.008463509,0.013422519,0.018273557,0.06589897,-0.028573874,-0.03211663,0.014835165,0.11887786,0.046637557,0.006135754,-0.07816153,-0.059920587,-0.0014412807,-0.06081197,-0.004240312,-0.09996618,-0.011723956,-0.03210505,-0.14428714,0.009755906,0.012074892,-0.05552537,0.014274655,0.015322628,0.018908001,-0.0073064035,0.020216482,0.047497634,0.051654052,0.013193914,0.0025620363,-0.0028367185,0.0019984283,-0.029902244,-0.055338383,-0.039170247,0.016545277,0.08804975,-0.00091726147,-0.048026133,0.04901761,0.08991198,0.019693123,0.08210909,0.052554257,-0.0006842294,0.08597252,-0.096070394,-0.041205984,-0.10466315,0.0403213,-0.05429199,0.02162311,-0.033135373,-0.06306863,-0.07295324,-0.0508853,-0.03308949,-0.02851314,0.01570885,0.016525142,-0.077856064,-0.0010468257,-0.051279984,-0.027778521,-0.062640645,0.025554476,-0.021917611,-0.07021821,0.021890229,0.12226967,-0.06514101,-0.043938573,-0.011133609,-0.06277144,0.014162579,0.024398053,0.015358777,-0.032093897,0.03881923,-0.029686052,3.949321e-33,-0.06282452,0.029393744,-0.034145348,-0.012319031,0.05809063,0.019583145,-0.0038001505,-0.03977676,0.012460058,-0.13433784,-0.14271739,-0.009491675,-0.0007815387,0.10524637,-0.021993006,0.008553386,0.004642398,0.018222926,-0.052893456,0.009342355,0.07362179,0.063373744,-0.021625819,-0.0017916526,-0.015873076,0.020766124,-0.0051775356,0.04052633,0.13790853,-0.031666204,0.02633562,-0.052641384,0.047772415,-0.0016354251,0.014035628,0.06998916,0.022663856,0.051694985,0.041939612,0.00010799182,-0.076901555,0.03420767,-0.11641325,0.0013889644,0.055370353,-0.018661205,-0.025654089,-0.0069326553,-0.0106619755,0.013760742,0.07894622,-0.07779606,-0.04176471,-0.09540053,-0.021910628,0.00021221337,-0.009242744,0.07990214,-0.017107697,0.003351248,0.038055878,-0.030493991,0.03404748,-0.03096703,-0.0028999834,0.002644445,-0.020582555,-0.051436525,-0.051020853,-0.054172225,-0.041884344,-0.019430352,-0.02947279,0.08854754,-0.0039658085,0.005042215,-0.059958663,0.015285399,0.06451654,-0.029507892,-0.109684795,-0.032289363,-0.020616852,0.05302433,-0.026617838,-0.023320053,-0.0057440135,-0.05359394,0.035321955,-0.0207215,-0.03409551,-0.04397729,-0.020026337,0.038345903,0.021061009,-6.2175974e-33,0.035419483,-0.02013031,0.06288046,0.04923852,-0.0023782402,0.14480202,-0.013659815,-0.07381701,0.11804675,-0.005747995,0.03820697,-0.008587018,-0.033988006,-0.017415218,-0.0357937,-0.039056934,0.038466677,0.0724392,-0.084898435,0.0077167465,-0.06127166,0.009889524,-0.01879183,0.0071925097,0.0058837323,0.117721826,-0.036666997,0.0642543,0.018927446,0.08697171,-0.034868747,-0.012927871,-0.027863795,-0.085582145,0.06237189,0.08171744,-0.046439562,0.024582552,-0.07345615,-0.01069532,0.023116844,-0.043862186,-0.03946596,0.16792105,-0.011573033,-0.018229878,0.00077466393,0.029600563,-0.018239556,-0.053179804,-0.0130294105,0.037243895,0.07970814,-0.0178445,0.033096664,0.028473493,0.071217544,-0.024393683,0.050702337,-0.032460053,-0.05412254,-0.06472321,0.05068863,0.04434445,0.0032923867,0.032549735,-0.084040105,-0.02883813,0.05457523,-0.10279058,0.029347382,-0.0033001816,0.020199094,0.022335082,0.046957735,0.013904399,-0.05887026,-0.08877575,0.035957783,0.004074732,-0.058298405,0.013503353,0.01154944,-0.0056595765,-0.018533718,0.011019906,0.074188806,-0.06302588,0.0015732662,-0.008371801,0.051985297,0.071924664,-0.012993252,-0.0038320217,0.026637001,-3.4960976e-08,0.10380348,-0.04382748,0.028240776,-0.038258348,-0.038302608,-0.029885974,-0.07996721,-0.037758805,-0.009599993,0.014845805,-0.0035505816,0.13221025,0.007538192,-0.038348127,-0.00080539926,-0.019470178,-0.037009418,-0.001138035,-0.043983713,-0.013324325,-0.13595916,-0.0009987052,-0.03142401,-0.012517357,0.07306252,-0.01568959,-0.059747633,-0.03927077,-0.020538796,-0.0067329896,0.08915805,-0.02209903,-0.029758343,-0.032701347,-0.0058395,0.020498803,-0.016515536,-0.035915464,0.05892725,0.009121627,0.097405404,-0.045536052,-0.09213354,0.018933587,-0.07935782,0.021966245,-0.007547797,-0.030273605,-0.060659576,-0.0003329479,0.040360127,-0.038682975,0.045142874,-0.007977943,-0.08937352,0.02710872,-0.0042000883,-0.046848077,0.0008148835,-0.072829306,-0.08493261,0.013314949,0.1257965,0.03882561 +2.3.1.60,Also acetylates sisomicin.,384,1.0,-0.046016514,-0.11254095,-0.10226187,0.0563009,-0.04074868,0.0023931595,-0.040970612,0.04573861,-0.0023744511,-0.027875377,0.04925927,0.08741236,-0.06257119,0.00064633903,-0.047030136,0.017175911,0.037924174,0.11954748,-0.022071362,-0.089342125,-0.020825194,-0.02605511,0.012186863,0.0042370665,0.06513213,-0.01695852,-0.050837167,-0.0057051545,0.01989353,-0.06756915,-0.004402634,0.080100745,-0.015543411,0.00196673,0.017414344,0.06719426,-0.0067662005,-0.024931299,0.033650935,-0.038585898,0.024278559,-0.04058135,0.023195002,-0.047471642,-0.0014927057,-0.06719788,-0.084326096,0.009592984,0.06957347,0.07090081,-0.10204287,-0.07801896,-0.012152681,0.05340959,0.0173568,-0.003495759,-0.09009194,-0.027351644,0.030813783,0.0015645507,0.027902205,-0.07373799,-0.03009585,0.0063742455,-0.0508206,-0.007396611,0.015671493,-0.034820996,-0.004233885,0.07429845,0.069861464,-0.045895476,0.0019021409,0.12900147,0.050169278,0.05259541,-0.07072993,-0.13165483,0.08333785,0.026486242,0.031884033,0.11497812,0.013562873,0.08210269,0.05504743,0.011968329,0.0076191253,0.027881047,-0.09435367,-0.012863681,0.05152067,-0.03594804,-0.043395065,-0.06132643,-0.03767562,-0.024499312,0.03308663,-0.044389546,-0.0427628,-0.0041803652,-0.029526878,0.05129791,0.04887634,-0.050030045,-0.043923695,0.0061681103,0.03478684,0.0060238913,0.044832427,0.0068410644,-0.046693917,-0.019585485,-0.018464928,-0.019290948,-0.02889017,0.095962346,0.08711408,0.03705949,0.026240317,0.03327245,-0.0036264735,0.010438943,0.056219358,0.053395893,0.049033076,-0.0067029432,-0.031264514,6.856195e-34,0.03652372,0.02083876,0.041225094,0.014906567,0.089961305,-0.026525091,-0.052870307,-0.03782343,0.08078306,-0.037107732,-0.08741167,-0.008480892,0.02558889,0.038696002,-0.020185819,-0.029622653,-0.06079372,0.009993477,0.032972507,-0.0015222374,-0.001793511,0.050514393,-0.03826669,0.035408538,0.010517285,-0.021165332,0.006359024,0.049713936,0.010108557,0.014961191,0.010466565,0.020194096,-0.027535304,-0.015856735,-0.05393826,0.0642535,0.025582204,-0.09407023,-0.0004613871,0.115256116,0.07512889,0.027028805,-0.0038369785,-0.06441909,0.028257985,-0.07079024,-0.014195198,0.011727159,0.02189345,-0.0060687694,0.037889145,-0.039419744,0.07985168,-0.010526155,-0.028009132,0.022123765,-0.04553233,-0.00836859,0.04451504,0.058550738,-0.018715266,-0.055289097,0.029772071,0.013204925,-0.05666006,-0.005527019,-0.117938384,-0.08781886,-0.08593501,0.025014654,-0.046121605,-0.04323841,0.110969536,0.041708052,0.007697689,-0.004234182,-0.013378808,0.017801795,-0.030875754,-0.029124092,-0.009960256,-0.022417918,-0.0040286803,0.072868325,-0.040189188,-0.024274046,-0.046429735,-0.04483199,0.078050494,-0.02155073,-0.047881227,-0.037375517,-0.046217054,0.013916318,-0.05298416,-1.25279275e-33,0.02440483,-0.10080618,0.054262944,0.0186303,-0.018482888,0.08728419,0.029582283,-0.029567532,0.021381255,-0.01890953,0.12024652,-0.03191708,-0.027974239,-0.08686316,0.030522326,0.067710236,-0.018026266,0.054120816,0.0025885722,0.056524284,-0.046880532,0.055310432,0.053792663,0.029003836,0.12758398,0.054958887,-0.04994225,0.00067754195,0.0012810873,0.09896955,-0.022701181,-0.038136512,-0.07992541,-0.07917534,-0.04822853,0.041037206,-0.061991222,-0.017680766,-0.10713415,-0.033939343,0.007911932,-0.014123951,0.0167374,0.114229046,0.10863321,-0.02886198,0.05858484,0.0023464826,-0.013980376,-0.034539443,-0.026407823,-0.019640986,-0.053712297,0.007853044,0.041595805,0.069320835,0.01207515,-0.039254505,0.0036935448,-0.015216104,-0.09105768,-0.015627641,-0.016245153,-0.022306226,0.13865614,0.107279636,-0.044036333,0.006550596,0.018961862,-0.018543381,0.059980433,-0.0012730206,0.068519816,0.12163772,0.02652397,-0.033441473,-0.026725866,-0.058717694,-0.045802098,-0.043396205,-0.08715421,-0.08239704,-0.08211531,-0.027730905,-0.07751662,0.04204686,0.0061048525,-0.019159582,-0.016498026,0.07106174,-0.06699938,-0.015373906,-0.066399775,0.042533875,-0.0016899918,-1.5683183e-08,0.09088494,-0.028445804,0.031147785,-0.059538584,-0.045462627,-0.05628403,0.06210867,0.020805666,0.019733768,0.012870164,-0.08224436,0.12074789,0.08329222,0.01629758,-0.012839279,0.012754543,0.031078223,0.07845962,-0.05090926,-0.02841236,-0.0812694,-0.018762035,0.041532345,0.004587157,-0.036878772,-0.049423125,0.056018654,0.11909286,0.0714385,-0.0013598126,0.026080437,-0.012982026,0.060133766,-0.054679766,-0.013696917,0.057491697,0.013886607,-0.03912337,0.0037183529,0.021780713,-0.061219186,-0.010637017,-0.035972487,0.02331625,0.015005968,-0.05666331,0.04371758,0.01595688,0.06622437,-0.021146238,0.020537734,-0.009179329,-0.02015699,-0.026071597,-0.02858503,0.047532786,0.024804667,-0.04252487,0.04877186,-0.0121516865,-0.035302375,-0.024895644,0.1549846,-0.008066516 +2.3.1.61,"A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.",384,1.0000001,-0.08167113,-0.05737093,-0.047369644,-0.023225725,0.08881958,-0.003619131,-0.09649595,0.008534247,0.00072144833,-0.05996661,0.087453745,-0.08386238,-0.06667262,-0.027635876,-0.004777916,0.03752937,-0.11789493,0.0023072613,-0.07663337,-0.07224863,0.091109075,-0.009702162,-0.03585474,-0.004389269,0.010039761,0.040392656,-0.026011001,0.0013357452,-0.025575222,-0.10940322,0.018231593,-0.04538034,0.02935044,0.0040646996,0.0058597806,0.087868,-0.028597062,-0.08848283,0.04999912,0.08098521,0.033269797,-0.0015143392,-0.039156903,-0.051107768,-0.04522501,-0.046976563,-0.036310505,0.032398287,0.051319204,0.011888656,-0.04852263,-0.09690963,-0.0131422505,0.044135135,-0.018843893,0.08654448,-0.028424017,0.029747952,-0.07529211,-0.006589065,0.048564605,-0.0031444803,0.0077834036,0.01627108,-0.0033725556,-0.030592225,0.07219964,-0.0629422,0.03440573,-0.0045824847,-0.07043778,-0.09784522,-0.024453599,0.013257461,0.011681596,0.009050555,-0.043962084,-0.08173747,0.0058563356,-0.025778921,0.042410124,-0.029893212,-0.007247545,0.019611873,0.088967666,-0.036254317,0.016583974,-0.059091836,0.05146113,0.039313402,-0.011922611,-0.042966597,-0.023903811,0.056789923,-0.041475933,0.09231532,0.021046244,0.096527465,0.02078977,-0.036041766,0.029636046,0.054113008,-0.009370371,-0.04763679,-0.015781583,0.018366603,0.020174077,0.023866419,-0.036474794,-0.0003723127,0.021707812,-0.04625026,0.11073397,0.023305276,-0.004642877,0.1012243,-0.014898234,-0.02218522,0.002717277,-0.015082234,0.044965215,-0.021143822,0.1334945,0.07284896,0.010497556,0.078830615,-0.15227361,3.8843285e-33,0.038808715,0.008138183,-0.009333467,0.05915259,-0.046591345,-0.01571256,-0.1321817,0.11445719,-0.119233675,0.040966354,-0.031083811,-0.049682878,0.08143766,0.02294621,-0.07829279,-0.07352322,0.00371786,0.007530725,0.03849097,0.06834829,0.032627057,0.055733547,-0.07977945,-0.02144628,0.010047391,0.02202705,-0.022582985,0.0012485953,0.078399286,0.0322256,0.025375636,-0.11650933,-0.051582843,0.043262918,-0.011406219,0.015165052,-0.039200537,-0.033543218,0.005868645,0.039726745,-0.002914319,-0.016681725,0.0024652425,-0.089531735,0.07115068,-0.028433599,-0.06442404,0.07719524,0.06453884,0.0025473004,-0.017032437,-0.0695577,0.09929363,-0.03739131,-0.026999997,0.021940976,-0.07093586,0.06643045,0.041040316,0.09313333,-0.03083265,0.066962406,-0.08680496,0.018777046,0.0448611,0.063748956,-0.09010779,-0.028261539,0.019631812,0.06664682,-0.04960422,0.015815634,0.03704052,0.04068187,0.07313121,0.00040130658,-0.024254896,0.06457024,0.038826197,0.05820002,-0.042806577,0.06686537,0.003401345,-0.023990026,-0.05825422,0.006734263,-0.032253075,-0.026379507,0.019241067,0.10227859,0.0001155047,-0.049792413,-0.029751584,-0.009605089,0.017376414,-5.0158304e-33,0.0471188,-0.060126014,-0.010461194,-0.059512205,-0.05413237,0.11123293,0.05318834,-0.04311497,0.042835213,0.025124341,0.10086299,-0.00197758,0.013605738,-0.07180429,0.04772522,0.051932584,-0.06571158,-0.0040307934,0.0020797343,-0.015370811,0.010951931,0.04452678,0.07067691,0.06648613,0.036381047,0.0037550777,-0.009933444,0.022570167,0.034875363,0.055654954,-0.05900998,-0.042874936,-0.0059523806,0.056362983,-0.06292538,0.06088136,-0.12743123,0.020797504,0.01553018,0.05748319,-0.09066793,0.01524402,-0.01147664,0.029342491,0.064934015,0.03706936,-0.09613372,-0.005406833,0.020053403,-0.03685679,-0.036638007,-0.016562313,-0.011545213,0.0045628,-0.002596143,0.070685074,0.036491238,0.014429896,0.004225534,-0.0739349,-0.0076424815,-0.044222996,0.03662126,0.0036288507,0.041515835,0.022608537,-0.043358367,-0.018857982,-0.0041806437,-0.010557065,0.0415004,-0.016269006,0.01800806,-0.00507615,0.04789052,-0.06283799,-0.07846828,-0.021773288,-0.09185775,-0.06344372,-0.02657016,-0.03658482,-0.0014755968,-0.069527134,-0.010547604,-0.045323335,0.05375864,0.076827876,0.005523575,0.00354324,-0.036597412,0.031573575,-0.07029677,0.017620945,0.08494984,-4.6075215e-08,0.041941456,-0.02964419,0.050289575,-0.039900847,0.07731276,0.054017715,-0.0045132213,-0.014885059,0.04219628,0.050983332,-0.043380518,0.08427861,0.05000149,0.04798328,-0.002813866,0.0022058669,-0.066779055,-0.009368368,-0.0010338037,-0.050144024,-0.024149401,-0.028383318,-0.112480655,0.03354892,0.0038082483,-0.060424235,0.020974528,0.039417084,-0.068994395,-0.06411279,-0.025252506,0.04395135,-0.018407235,-0.028291829,-0.0718694,0.008954614,-0.011539375,0.020297172,-0.06920579,0.09164249,0.038758714,-0.054961454,-0.05296979,0.035609175,0.08291156,0.0022473896,0.013862048,-0.0014807385,0.020664869,0.040549446,0.034324594,-0.023172194,0.03158152,0.038344327,-0.043838695,-0.021438656,-0.06972743,-0.05886498,0.026301222,0.008436776,0.007184965,-0.0067769503,0.15265338,-0.06444833 +2.3.1.63,May be identical with EC 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase.,384,1.0,-0.091511995,-0.032543454,-0.06647219,0.008751214,0.029782962,-0.043580525,-0.0517593,0.061378725,0.06959838,-0.12627658,0.11571425,-0.057768494,-0.06496782,-0.03432356,-0.020147465,0.02631412,-0.021670217,-0.063310176,-0.009996274,-0.047475863,-0.019062927,0.041292604,0.051019736,0.015070021,0.03651824,-0.024840107,-0.023776682,0.03876375,0.00039783752,-0.099390626,0.05765869,-0.045105893,0.0007918076,-0.027369998,0.10325077,-0.026056075,-0.006839979,-0.050656967,-0.032053407,0.05052023,0.07862308,-0.042331487,0.024409978,0.054377917,-0.011555884,-0.025705282,-0.055058625,0.039462354,-0.021062696,0.055076305,-0.020657586,-0.0937557,-0.08951288,0.0031417806,0.03128842,0.055412684,-0.075930014,-0.0017286472,-0.06763722,0.02844478,0.005359582,0.033147883,0.0051237633,0.008271808,-0.040462054,-0.021137891,0.092875265,-0.18497641,0.1222071,-0.021516336,-0.07737784,-0.08922216,0.03811746,0.054707915,0.053900488,0.06183117,-0.011276634,-0.019743819,0.035181236,-0.08852013,0.039635934,-0.0650755,-0.045720436,-0.0030139724,-0.024987655,-0.07979112,0.027946059,-0.012910123,-0.0040213293,0.019060096,0.0042230976,-0.044635877,0.023800615,0.01938982,-0.060951125,0.049524892,0.054239,0.08842061,0.023225103,0.0071568955,-0.011066722,0.086275905,0.012069717,-0.043844387,0.01306105,-0.0013818827,0.015028299,0.015846457,-0.004382752,-0.039416954,0.030163484,-0.09239044,0.048098464,-0.020507494,-0.013725864,0.09011971,-0.054990657,0.0075517013,0.056682277,0.06419048,0.04688033,-0.051812466,0.009507378,0.006253827,-0.051952746,0.07697789,-0.091477506,2.3001398e-33,0.056253627,0.060090158,0.0251307,-0.027779602,-0.017322773,-0.0033342445,-0.10304553,0.019314015,-0.07139692,-0.022731477,-0.057168532,-0.08061942,0.015181579,0.058765654,-0.0072542806,-0.049895633,-0.041224524,0.024272967,0.03721288,-0.004956891,0.0655629,0.040319897,-0.03789191,-0.03873929,0.08406352,-0.00046035406,-0.011345897,0.026770229,0.04106016,0.00829969,0.03715381,-0.08200566,-0.050175235,-0.028041182,-0.017356226,0.0070238253,0.009338441,-0.090141475,-0.0060900613,0.035976022,0.028650573,0.0462098,0.028082328,-0.066895396,0.08163054,-0.049110252,-0.115093246,0.053411517,0.10634151,0.023815965,-0.03610889,-0.033453245,0.13170779,0.08395961,0.01255396,-0.055993322,-0.046371825,0.05126957,0.034542378,-0.046497732,0.028180435,0.13577631,-0.034059983,-0.03489766,-0.010400626,0.04544477,-0.050756995,-0.013087237,-0.078532726,0.021250866,-0.009219772,0.0010699559,0.029912828,0.011707579,0.06608059,-0.07096399,-0.06955349,0.04348671,-0.024552993,0.011579279,-0.08335546,0.039568752,0.056979284,-0.012467984,-0.12032885,0.046786096,0.014784365,0.03178235,0.039439004,0.05281678,-0.018695844,0.053482026,-0.044796966,0.034327578,0.0003450546,-2.4063422e-33,0.01889136,-0.008571663,-0.007085163,-0.00972851,-0.013524552,0.019636493,0.008707538,0.08673868,0.06777344,-0.022195807,0.13156481,0.0057934984,0.0014614812,-0.12100011,0.12673107,-0.02866341,-0.107976906,0.01811233,0.06807272,0.09726407,0.0028463374,-0.0021435528,-0.022395201,0.11573471,0.037581574,0.010340094,0.035914674,-0.021813989,0.011460229,-0.0011148162,-0.03378272,0.04039812,-0.02840107,-0.033001866,-0.08303727,-0.011920226,-0.016249878,-0.023969427,-0.04027246,0.03274264,0.0006628403,0.03898147,0.04435264,0.009071423,0.043954413,0.120579354,0.047619704,0.010439555,-0.009608147,-0.055106066,-0.026978958,-0.013724817,-0.047128912,0.019648118,0.022192575,0.107818864,0.012815365,0.02628272,-0.008615666,-0.070223846,-0.03563198,-0.02116418,0.032709915,0.009396327,0.069735005,0.0809449,-0.026314637,0.024685774,0.045150645,0.022466019,0.014915088,0.008631731,-0.07594345,-0.03206832,0.04639146,-0.027081043,-0.01287933,0.029602533,-0.0036977478,-0.0765252,0.04817993,-0.005693298,0.04463359,-0.008422924,-0.02077746,0.0096829515,-0.03440315,0.051998705,-0.009861918,0.06625348,-0.03365883,0.0030997403,-0.14240816,0.008676393,0.006727972,-2.5177618e-08,0.08653475,-0.020941952,0.03419282,-0.0034031523,0.0042549577,-0.014781331,0.01739831,0.03831983,0.0062800534,0.017863082,-0.045424376,0.058342554,0.045627065,-0.031641293,-0.0014052255,-0.007962989,-0.04111956,0.083518155,-0.011961825,0.007154302,-0.055132322,0.005279036,0.01823232,0.0045178966,-0.027202833,0.0140500385,0.019515093,0.052937943,-0.030862533,-0.06908455,0.013122261,0.026158312,-0.0060410695,7.583886e-05,0.0266276,-0.0076012723,-0.04547335,-0.03987969,-0.038884073,0.089412905,-0.0073583606,-0.036541745,-0.03075134,0.023317743,0.0884947,-0.06397315,0.051748585,-0.006708856,-0.026199061,-0.0633107,-0.039809875,-0.021259058,-0.021027673,-0.07630674,-0.07000378,-0.04887237,-0.07145285,-0.06502498,0.0055990308,-0.031373795,0.043689538,-0.03666315,0.16198811,0.014755448 +2.3.1.65,"Also acts on CoA derivatives of other bile acids. Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly [4]. The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase [7]. Bile-acid---amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol [4]. This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalysed by EC 6.2.1.7, cholate---CoA ligase.",384,1.0,0.0055788676,-0.14922771,-0.035471685,-0.06643122,0.047058444,0.07341754,-0.10365742,0.027973026,-6.8545276e-05,-0.009529839,0.022624455,0.0016349533,-0.024320181,0.0346323,0.023926817,0.043448128,-0.020944707,-0.015549495,-0.04672908,-0.06560368,-0.006420148,-0.06590533,-0.041384727,-0.012086277,0.000997718,-0.0052444,0.062875405,-0.09249231,-0.01809165,-0.05129801,0.007930794,-0.097230144,0.021292824,-0.041913018,-0.09049976,0.015707895,-0.033790164,0.004690269,0.049348336,-0.001977191,0.07448458,-0.0030484595,-0.032568775,-0.043558992,0.01112177,-0.09245794,0.07762701,-0.014985673,0.028632017,0.07338834,-0.063965686,-0.01633673,-0.046818763,0.023490136,-0.005568978,0.0703319,-0.07828,-0.05844569,0.0058015315,0.047989156,-0.03212638,-0.034343954,0.025530523,-0.0068954085,0.0011820411,-0.048054516,0.042629138,-0.029785478,0.056753933,-0.04943545,-0.052239895,-0.02390013,-0.045927633,-0.008515407,0.0415282,0.015921203,-0.062465005,-0.016010223,0.027508304,-0.081132315,-0.050655685,-0.051418636,-0.011594574,0.049862858,0.07370734,-0.004033799,0.010009186,-0.034141663,-0.006492966,-0.011106578,0.05737375,-0.021110235,0.026975656,-0.04816993,-0.0070597325,0.0037549483,0.022626184,0.015979202,0.057813108,-0.012907169,0.012656663,0.10044018,-0.014214149,-0.07980908,-0.064817205,-0.0084428,-0.015183712,0.09634324,-0.018201774,0.022606043,0.028233815,-0.042346958,0.08533076,0.015093311,-0.016716719,0.13510127,0.007207773,-0.06295508,0.03078211,0.09419429,0.0051482734,0.028048988,0.07552586,0.08977239,0.03781244,0.03737048,-0.018089091,5.184412e-34,0.022863068,0.045160916,0.028620102,-0.005542981,0.021639146,-0.04353168,-0.0850387,0.04597201,0.0083725285,0.04606417,0.09057696,0.013464861,0.008944945,0.010285286,0.039724577,-0.014715021,0.07081967,0.01441135,0.048099987,0.03230925,-0.0217201,0.06564747,0.011612331,-0.040866394,0.037477925,-0.040975083,-0.03737478,0.07757918,0.010203183,0.04207444,-0.029110935,-0.06260554,-0.08591642,0.07509941,0.005600628,0.016880386,-0.114874676,-0.0015083565,-0.0036972067,0.09644737,0.08269226,-0.055666037,-0.01575412,-0.006644823,0.012846863,-0.04498579,0.008050583,0.050479833,0.013924603,0.033336792,0.07052081,-0.039617185,0.07179367,-0.056390576,0.0031915188,-0.010425919,-0.0053338287,-0.034902304,0.010637072,0.06545137,0.0119697815,0.040628295,-0.07653173,0.056572773,-0.050242823,-0.057482064,-0.060483057,-0.037244134,-0.03396598,0.047708053,-0.029105436,0.008204621,0.0257672,0.017446926,0.027389562,-0.032773037,-0.0644568,0.023370234,0.034301344,-0.04465573,-0.014879266,0.021290658,-0.023003457,-0.012832321,-0.06781271,0.003633197,0.009798348,-0.09305818,-0.025510108,0.0015522976,-0.044255964,0.013978392,-0.028015014,0.036001544,0.08734421,-1.4560019e-33,0.053912263,-0.110840514,0.0034177518,-0.071931854,-0.07296033,0.051777042,0.0538526,-0.0438816,0.06416731,-0.057879828,0.033465322,-0.0031928576,-0.0145903835,-0.07192656,-0.017381325,0.015414894,0.09949887,0.043660108,-0.01811492,-0.10277268,-0.02504075,0.065006256,0.06413004,0.06971087,0.016223198,0.027424548,0.022160709,0.031090135,0.104260586,0.14428717,-0.024768718,0.016021235,0.005134883,-0.0031803367,-0.10783322,0.0067939046,-0.003342274,0.0054732673,0.0029141624,-0.021361364,0.0024247428,0.030823827,0.09072412,-0.0146969035,-0.028952325,0.043461736,0.0012061459,-0.03282345,-0.057429854,-0.09204955,0.063887395,-0.03924426,-0.03086477,0.015452316,0.0057379208,0.13210462,-0.037006304,-0.017793544,0.05181825,-0.11529064,-0.08671421,0.0040195123,0.019773716,-0.074216686,0.0010315002,-0.010164971,-0.059460297,0.0125110885,0.001560892,0.029499521,-0.0038059177,0.04997621,0.041306857,0.055898197,-0.013610712,0.0039053652,0.0135279745,-0.071721785,0.006744223,-0.08051293,-0.024855455,-0.042675372,-0.045640055,-0.07545086,-0.05247992,-0.05914221,-0.03180323,0.1049808,0.050559845,0.046026696,-0.032269668,-0.013001393,-0.01671143,0.0658884,0.026534852,-3.96429e-08,0.051944878,-0.07339894,-0.025064096,0.039511006,-0.033488844,0.08386922,-0.03452548,-0.060231313,0.01561165,-0.045775093,-0.09668588,0.13624826,0.058152173,0.0008648435,-0.044473447,0.07178414,-0.044455506,-0.006587058,-0.0064500663,-0.05165381,-0.07652386,0.022191381,-0.043709915,0.04608466,-0.006499447,-0.017123802,0.0059458674,0.017825777,-0.027850911,0.038754094,-0.00092594087,0.0039433525,-0.016129347,-0.022084298,0.013972762,-0.040109836,0.059718244,-0.03941664,0.0035261149,0.093655005,0.096285604,0.032148067,-0.11465107,0.026755966,0.043181233,-0.039573185,-0.010646668,0.06847909,-0.020848528,0.02976732,-0.006171143,0.019412715,0.0025279261,-0.020292936,-0.049424373,-0.0333012,0.013092723,-0.13177651,-0.03473785,-0.0067538037,0.037548624,0.047438785,0.24515533,-0.0077934596 +2.3.1.66,"Propanoyl-CoA can act as a donor, but more slowly. L-Arginine, L-valine, L-phenylalanine and peptides containing L-leucine can act as acceptors.",384,0.99999994,-0.10649991,-0.13927749,-0.07429291,-0.03334733,0.13012718,0.07829645,-0.044478342,0.05029084,-0.0028995106,0.023623308,0.054671332,-0.011775346,-0.09786016,0.11994201,0.06956566,0.09749801,-0.0052967393,0.027495028,-0.034291398,0.0423951,-0.054896604,0.00798637,-0.06619189,0.023953436,0.049102616,-0.022722341,-0.0062804604,-0.03228906,0.049534112,-0.022931695,-0.04077081,-0.06258099,-0.036659896,-0.003490034,0.02112766,-0.002646119,-0.1102192,-0.0034181913,-0.05238883,0.03297601,0.038972523,-0.11480308,0.002039312,-0.027421296,-0.031644613,-0.06387306,0.0363392,0.031655397,0.002565291,-0.008657273,0.017075576,-0.02095078,-0.068751894,0.099378325,-0.09574976,0.041117627,-0.103031315,-0.018417455,0.052874185,0.00048199866,-0.039406322,0.075341836,-0.02140877,-0.013390949,-0.011481512,-0.02745069,0.009716765,-0.02178048,0.081331484,-0.015304189,0.10634751,-0.06013826,0.04894263,0.033487327,0.0932652,0.0024406991,0.012540969,0.031171974,0.0188213,0.03514897,-0.043142095,-0.0020444137,-0.044031292,0.02499198,-0.01431241,0.019092763,-0.07812791,0.082996815,-0.047597036,-0.050119944,0.04806521,-0.018598348,0.041462786,-0.01812111,-0.030458638,-0.017778806,0.03550327,-0.03743715,0.045098156,0.020175533,-0.090867355,0.09843523,-0.08829845,-0.050413348,-0.053451125,-0.016687196,0.0061646993,0.01950859,-0.008723014,-0.0015650925,0.03672845,-0.053487774,0.10210704,0.030875525,-0.0030995603,0.0122981835,-0.044526156,-0.08289291,-0.036840037,-0.010663539,-0.03689406,0.0012518927,0.06982966,0.039414413,0.025196001,0.076026276,-0.036268078,1.2010204e-33,0.076185204,-0.03388641,0.05610475,0.037837483,-0.06564122,-0.01838896,-0.009494079,-0.0035533367,0.02574416,-0.08928951,-0.06715378,-0.03472987,0.054907996,0.13514717,-0.08391147,-0.021218702,0.022519948,-0.007625146,0.058158208,-0.023318274,0.013716032,0.06972559,0.0053058784,0.05262517,0.022141019,-0.041961845,-0.02678607,0.075426556,0.058753315,0.008419133,-0.044082884,-0.067067906,0.0039758584,0.04107553,-0.0063506775,0.011306075,-0.008166238,-0.06382439,-0.0018176488,0.024817377,-0.015478733,0.041554116,-0.07076653,0.03127632,0.050343953,-0.035186276,0.0072798305,-0.027810596,-0.14078502,-0.012127023,0.0498444,-0.06573044,-0.05209068,-0.073200226,-0.0499191,0.0057747904,-0.022322094,0.035017435,0.020359533,-0.0060220878,0.008426646,0.041789588,0.010061212,0.064038016,0.0014197099,0.011817553,-0.029989433,-0.09206679,-0.039380874,-0.021055596,-0.05648825,-0.010417574,-0.020285329,-0.034337085,0.07059202,-0.076989695,-0.004900254,0.042699303,0.0560973,-0.005977513,0.003961593,-0.05451397,0.008554107,0.092328794,0.022381175,-0.07305814,0.019223692,-0.16739546,0.06373674,-0.057430316,-0.013551598,-0.052466866,-0.0013935888,-0.04859805,0.06670387,-1.881599e-33,0.09958389,-0.13973382,0.06301587,0.033176634,-0.00018073726,0.058325917,0.024709845,-0.074229725,0.119260006,0.0028664432,0.087327994,-0.011764935,0.04816985,-0.043942872,0.013324754,0.0011655294,0.0058349213,-0.015979538,0.010328924,0.00463595,-0.037257716,0.008045528,0.023724586,-0.024085337,0.017936166,-0.011597406,-0.068692125,0.04824567,0.049179513,0.018938722,-0.01950201,0.021712376,-0.054729868,-0.07169928,0.007990849,0.10346379,0.0006974933,0.06387626,-0.025666704,-0.051211584,-0.03560454,-0.06611362,0.00219106,0.050690472,-0.012352002,-0.07107826,0.041753456,-0.050039724,0.032187413,-0.07592857,0.027338015,-0.031538174,0.031204611,-0.0023605297,0.061187502,0.044033304,0.03597685,-0.0469086,0.047376473,-0.06715431,-0.019227618,-0.08086303,0.023854183,0.0010931506,0.049979646,0.0023804426,-0.007209399,0.016927307,0.059807964,-0.039459433,0.14564794,0.009804507,0.108155034,0.11941917,0.025729917,-0.099201754,-0.012877521,-0.050633255,0.006066821,-0.04380752,-0.07039715,-0.051297627,0.008742387,-0.025311612,0.032743715,0.03669528,0.034591917,0.016631072,0.0043448256,0.0203481,-0.027520353,0.032781947,0.07803547,0.074889205,0.074383825,-3.247528e-08,0.08120617,-0.016742257,0.004452612,0.008153434,-0.050846606,0.014199707,-0.020398332,-0.0353212,-0.024427608,0.046985183,-0.012449418,0.0989158,0.06025049,-0.028583927,0.0500508,0.019656198,0.034701742,-0.031561498,-0.04057279,-0.03484572,-0.049220607,0.0012726347,0.0068242154,-0.019356677,-0.002469074,-0.0331529,0.015387858,0.047509786,-0.0070392657,-0.008441395,0.035138723,-0.025721133,-0.050875463,-0.009332343,0.09035071,0.053365618,0.053641785,-0.045732036,-0.030692657,0.045650426,-0.007930365,0.04342228,-0.098539524,0.0028600388,0.012038989,-0.040224317,0.012860915,0.011327344,-0.06529871,-0.012804622,0.06392725,-0.059530344,-0.05502508,-0.024312787,-0.023209628,0.029553074,-0.015117857,0.012758944,0.06518216,-0.058941714,-0.040116623,0.043187935,0.10751707,0.003284824 +2.3.1.68,"Phenylacetyl-CoA and (indol-3-yl)acetyl-CoA, but not benzoyl-CoA, can act as acyl donors. Not identical with EC 2.3.1.13 glycine N-acyltransferase or EC 2.3.1.71 glycine N-benzoyltransferase.",384,1.0,-0.12440334,-0.09058321,-0.08385505,-0.03508815,0.031083437,0.063269995,-0.091436855,-0.017224457,0.0728673,-0.10895591,0.13075624,-0.07398345,-0.066922076,0.052693345,-0.015060272,0.02577314,-0.05034777,0.02315324,-0.0595426,-0.048506096,-0.05116596,0.05436509,0.052019846,-0.009531348,0.0653246,-0.10293315,0.0054983124,-0.017659301,0.027763434,-0.07744275,0.04232013,-0.078107245,-0.046958454,-0.025974404,0.07180548,-0.023296785,-0.0014265752,-0.050108355,0.08401061,0.06045483,-0.0049700676,-0.09851341,-0.057920046,-0.032053918,-0.039460436,-0.06051933,0.011489554,0.010875772,0.032023154,-0.03029573,0.029399281,0.029929927,-0.03243567,0.061972693,-0.031023135,0.05920447,-0.060325388,-0.00028388077,-0.056620307,0.042973805,-0.01945885,0.032478042,-0.030599887,0.00084212446,-0.069671065,0.0049221166,0.059288193,-0.069780536,0.06715629,-0.021939436,-0.079627,-0.11625214,0.023439856,0.031701244,0.03400561,0.037369587,-0.040051635,0.022476172,-0.012266059,-0.029529972,-0.06084131,-0.020204969,0.00023353382,-0.0044651763,-0.0041774497,-0.025575116,-0.071704276,0.030117918,-0.028509539,0.021244632,0.0034284138,0.0006196631,0.08514077,0.0006908197,-0.032255944,0.043316104,0.10641685,0.03027581,0.013896283,0.011032289,-0.02206885,0.1463465,-0.0018792835,-0.058099046,-0.067413114,-0.005462474,-0.016942658,0.011082412,-0.0058072857,-0.053187907,-0.013886274,-0.060834724,0.07560281,-0.03895114,-0.003374046,0.05599167,-0.106741205,-0.04058407,0.035494447,0.025788829,0.0017408507,-0.0149844205,0.056058377,0.0964043,0.046767548,0.06978782,-0.050692003,3.7591813e-33,0.07628667,0.06435321,0.066549726,0.043002494,-0.03179123,-0.022857837,-0.1322367,0.035451896,-0.01949696,-0.11549356,-0.009059689,-0.041145653,0.04221259,-0.0017548157,-0.0042735315,0.035626434,-0.041784726,-0.04149209,0.053835224,0.01428219,0.043588273,-0.006591913,0.019868607,0.02270374,0.020500958,-0.039739247,-0.010006473,0.111604266,0.04185407,0.039638594,-0.05215865,-0.06986487,0.021817068,-0.00027234489,-0.090112254,-0.0056006764,-0.009848104,-0.07243948,0.039709147,0.07945024,0.09227077,0.045681793,0.048092663,0.021404052,0.031480964,0.02952688,-0.028566945,0.03436366,-0.06843822,0.057182405,0.030331017,-0.034222458,0.06663229,0.025519323,0.0106564015,0.022730393,-0.049485672,0.03657223,0.016588077,-0.000106127576,0.0015447376,0.09367073,0.029603641,-0.04796207,-0.013006705,0.0224457,-0.054423008,0.01108428,-0.10753322,0.016177556,-0.017201275,0.009957745,0.06439583,0.108174615,0.12520497,-0.10505981,0.006560012,0.040178493,0.091042325,0.016441634,-0.04976674,0.05269488,0.06568358,-0.036900416,0.018557878,-0.049465477,-0.0146238785,-0.063121855,0.056880135,0.01676001,0.023717279,-0.03326555,0.00038554965,0.0012236265,0.020320246,-3.913273e-33,0.07331948,-0.067548856,-0.021858856,-0.096125335,-0.027170733,0.0093114,0.017180968,0.0026114115,0.058472626,0.021221405,0.0936029,0.0030574016,0.04306556,-0.07121478,0.092422254,-0.037396375,0.029518802,-0.024693629,0.015643414,0.025199337,-0.013643878,-0.03599167,-0.007645181,-0.012890681,0.028323948,0.044209234,-0.097527236,0.030472022,0.027880503,0.060308162,0.020549944,0.02757161,-0.08786877,-0.030961458,-0.031170191,0.048432246,-0.031232415,0.03703652,-0.086466394,0.00081067934,-0.04506918,-0.004892745,0.01717196,0.019309018,0.027060313,0.03895831,0.034419965,-0.05467531,0.0036984184,-0.106894195,-0.039386716,0.038566668,-0.011230186,0.019152183,0.018924907,0.11200189,0.09496175,-0.0046289186,0.052889276,-0.094237365,-0.051168356,-0.023339842,0.00720212,-0.035534155,0.052223567,-0.016483499,-0.010266942,0.094496675,0.08319573,0.005169653,0.06441503,-0.0423267,0.053345248,0.018879779,-0.024875445,-0.022383155,-0.046020433,-0.017090548,-0.08722502,-0.088626675,-0.040458586,-0.051999494,-0.008050444,-0.009700764,-0.04206592,0.0058957976,-0.009529953,0.021331467,0.0057695922,0.017984094,-0.024357824,0.04517673,-0.0126933,0.07383359,0.034465212,-3.6665323e-08,0.056990355,-0.022279514,0.027021518,-0.036582816,0.034616914,0.030302804,-0.09077742,-0.012377954,0.014296774,-0.0065544117,-0.07791304,0.053370286,0.03528551,0.022092562,-0.0695046,-0.0139345545,0.0109647615,0.060813937,0.01799383,-0.059388075,-0.1020708,0.05311842,0.010855833,0.0422688,-0.026914716,0.010819584,0.0386932,0.0012137033,-0.024871241,-0.08797946,0.028546635,0.006389781,-0.023645278,0.027687067,0.03403398,-0.031269554,0.07072714,-0.03279731,-0.054658826,0.053803302,0.02057471,-0.03918276,-0.08436244,0.07783908,0.12522066,-0.035334386,0.035499536,-0.0368175,0.026825547,-0.048743077,0.0112834,-0.025557382,-0.024919951,-0.075186126,-0.028391872,-0.045665897,-0.054543648,-0.00060377916,0.07332412,-0.027366785,-0.022501323,0.008770843,0.12269377,0.019502377 +2.3.1.69,"(-)-Menthol, (+)-neomenthol, borneol, and also cyclohexanol and decan-1-ol can be acetylated.",384,1.0,-0.023234483,-0.045909658,-0.10084259,-0.03130307,0.023973733,-0.01993787,-0.0012543076,-0.056081537,-0.027803855,-0.024051221,0.062392797,-0.008963516,-0.068729915,0.00069757,-0.056762658,-0.01646806,-0.07566299,0.08297755,0.027467558,-0.014494874,0.052214447,-0.0015382625,-0.064093284,-0.037965685,0.055278882,0.03429141,-0.041400343,0.010379761,0.017023243,-0.07662564,0.053351402,0.014510367,0.06884143,-0.043228906,0.08828779,-0.00015141652,-0.07307287,-0.014776511,0.038674086,0.006079665,-0.0038105228,-0.058747422,-0.012642449,-0.027755534,0.008291268,-0.08034898,-0.076953486,-0.0136095295,0.040964957,0.0074257664,0.023658555,0.010212507,-0.1378905,0.06888626,0.015691463,-0.008073622,-0.09987575,-0.019332545,0.017257268,0.014133571,0.035405815,0.031054385,-0.09449787,-0.007680006,-0.04543889,0.030889874,0.025045298,-0.0051266192,0.011103668,0.10233669,-0.022944713,-0.07510365,0.024165707,0.033442616,-0.010564672,0.050519817,-0.03880652,-0.063061975,0.07583527,0.012890503,0.08945929,0.08646816,0.043681223,0.07308067,0.0473597,0.08702576,-0.066377446,0.027512852,-0.0030726814,0.06723012,0.018428238,-0.013869596,-0.015124005,-0.07173501,-0.020869197,-0.0010363947,0.10951657,0.05880866,0.004521353,-0.009271991,0.027911887,0.028314322,-0.049847893,-0.1311631,-0.14602861,0.025953585,0.034068886,0.0005968661,0.042256534,0.07883369,-0.08847548,-0.055481955,0.04170686,-0.119790755,-0.038274314,0.042127877,-0.023196712,-0.03336963,0.015492256,-0.03242026,-0.027211532,0.042978644,0.03458438,0.078823574,0.046719465,0.040341936,0.08217563,-7.0652055e-34,0.011596324,0.10565302,0.023561759,0.029571531,0.0010928308,-0.019214008,-0.10495698,-0.09456712,-0.053064402,-0.041482218,-0.049566988,0.013439319,-0.04449017,0.023886295,-0.024101334,0.032929383,0.046845593,-0.052966658,0.016230406,-0.010397837,-0.019683223,0.08978934,-0.10096897,0.004589116,-0.028451744,-0.036584787,-0.016308036,0.005619982,0.05498514,0.015716277,-0.010888917,-0.036812093,-0.0031340767,0.0484526,-0.08987037,0.017466186,-0.02679491,-0.032876052,0.018382732,0.03909573,0.037463292,0.06322573,0.026486997,0.028740324,0.069750495,-0.03566978,-0.046053793,0.05637206,0.044427346,-0.020622917,-0.040584624,0.02081297,-0.061284095,-0.0075526913,-0.10457189,0.062694624,0.0042801714,0.07065037,0.046675038,0.047025494,-0.016225822,0.041894294,0.031159535,-0.036115423,0.009176372,-0.0032693064,-0.08661294,-0.038519345,-0.047958683,-0.039740693,-0.08571775,-0.039654035,0.076490834,0.07128812,0.09546549,0.032349367,0.042876955,0.03839205,0.0770504,-0.0053394763,-0.020134674,-0.020631662,-0.041213296,0.032830458,-0.0054761437,0.0061993934,-0.028102275,-0.039746244,0.014637459,0.048203174,-0.007941873,-0.07521122,-0.064384535,0.007931085,-0.044590376,-1.7732285e-33,0.030690217,-0.051639948,-0.017460134,-0.007776735,-0.08493324,0.08040778,0.04614287,-0.05906579,0.03184036,-0.030193264,0.08982733,-0.03015503,0.03522293,-0.055281166,-0.008480404,-0.07831112,0.026203485,0.083473854,0.0067724837,0.07851727,-0.025344044,0.037741017,0.014049071,0.025246896,0.118846826,0.04151863,0.036855005,0.00079970184,0.069456086,0.10589425,0.059339743,-0.031799603,-0.004820266,-0.05149006,-0.047786735,0.032222647,-0.02416044,-0.0011841719,-0.07883858,0.04573385,-0.08225851,-0.029827952,0.0017734354,0.0014009898,0.09628922,0.045883264,-0.059894104,0.007245821,-0.011546664,-0.065129675,0.032874316,0.06734601,-0.1287255,0.024563447,0.09513344,0.030185247,0.0134317065,-0.019420044,0.030327292,-0.050564114,-0.0941034,0.017693544,0.05480559,-0.11517615,0.062310196,0.06783774,-0.017036509,0.01922348,-0.003961286,-0.079536416,0.10441407,0.0052356436,0.019143173,0.10228001,0.05084326,-0.10545199,0.021686837,-0.050872777,-0.05428506,-0.07737183,-0.03723526,-0.024304887,0.005103785,0.0024479,-0.030686287,-0.040582336,0.011138316,0.045478396,-0.022173395,0.085415825,0.008945285,0.062169198,-0.075025685,0.07120836,0.036268707,-3.3963218e-08,0.0054246993,-0.058422126,0.01469374,-0.11051192,-0.046354476,0.015786948,0.057043474,-0.07062728,0.029221253,-0.12310871,0.029061144,0.05279808,-0.025039155,-0.007955464,-0.02080211,0.043155972,0.044755667,0.03949102,-0.007444422,-0.061058298,-0.072176896,0.059028212,-0.051035207,-0.034897543,-0.029451855,-0.030556468,0.06972695,0.023674076,0.0019334906,-0.055203002,-0.035391137,0.04801048,0.019000525,-0.017109416,0.028864129,0.025334526,-0.0045294515,0.01841817,-0.026984686,-0.0042548566,-0.02375942,-0.0427788,-0.05847227,0.01340706,0.059933804,-0.045658145,0.023054114,0.044468336,0.014965395,-0.04133071,0.051659107,-0.041043114,-0.006974015,-0.065188766,-0.02906606,-0.033265516,-0.028467283,-0.023821041,0.012393095,-0.03872687,0.00039847646,-0.009089604,0.082654394,0.015354186 +2.3.1.70,Highly specific for both donor and acceptor.,384,1.0,-0.07989802,0.037654687,-0.053971935,-0.044846486,0.0117919305,-0.05185633,0.037954353,0.06649016,-0.0035010779,-0.042628717,0.07848494,-0.024655608,-0.098272555,0.06422483,-0.052439705,0.025143743,0.03389498,0.0016020988,-0.020427743,0.021273486,-0.015734771,-0.007596464,0.020754628,-0.054907534,-3.735868e-05,-0.05886197,-0.023967434,-0.018502023,0.04615987,-0.056801032,-0.030187922,-0.024797041,0.044934362,0.033700187,-0.033564735,0.058581084,-0.04349411,0.06713054,-0.05476312,0.028935865,0.040027242,-0.06363978,0.04750714,0.011089217,-0.020233208,-0.022196963,0.026015388,0.0187281,-0.010986826,0.039826944,0.058631044,-0.02284561,-0.030753378,0.11840695,-0.014282015,0.03382187,-0.07116096,-0.07044391,-0.0473587,-0.014382303,-0.04318069,0.014692887,-0.04485326,0.0073944423,0.08881926,0.0010441957,0.03850219,-0.08022598,0.007492255,-0.09109459,0.043608848,-0.044036563,0.047453467,-0.003246719,0.043396514,0.03947628,0.003722183,0.03782599,0.013991473,0.050459266,-0.038961522,0.031468447,0.017263748,-0.005995861,0.08227048,0.08858011,-0.08105206,0.059705064,-0.0681532,0.06772094,-0.0033390697,-0.0073803267,0.062738605,-0.091013804,-0.042658452,0.015915634,0.050336346,-0.047154993,0.024556536,0.00892872,-0.018591847,-0.016103765,-0.015232042,-0.005184482,-0.050307732,-0.061055567,-0.043377466,-0.03150209,0.032992426,-0.031183379,-0.014688009,0.009104401,0.09216668,0.05020944,-0.021022266,0.11138651,-0.063930534,-0.045098975,0.08964301,-0.039422974,-0.028754713,0.002190287,0.024862474,-0.06896388,-0.055913042,0.0130786225,-0.07387461,-1.5538123e-33,-0.021025429,0.048382457,0.042741284,0.10096185,-0.053831436,0.08507523,-0.0365281,-0.052251622,-0.0019073744,-0.049236365,-0.08333007,0.017786877,0.05592221,0.059659068,-0.09411318,-0.011057373,-0.072556265,0.0768764,0.018455656,0.0035283149,0.041834164,0.09614833,-0.060258027,0.048815645,0.080242604,-0.033871736,-0.028341943,0.014179726,0.0011056216,-0.020374782,0.035661463,0.014344025,0.037462767,-0.03591755,-0.032579225,0.026422804,-0.0027912436,-0.030174397,-0.024849417,-0.04256458,0.0152306575,0.050757743,0.0122631835,0.08921645,0.068811305,-0.047616813,-0.0019001678,-0.08653252,-0.044058748,0.01915141,-0.06827869,-0.026239652,-0.03251633,-0.11692728,0.005518487,0.01397938,0.004567764,0.06426486,-0.051659554,0.03226824,0.00022352909,0.059019692,-0.006270602,-0.015298251,-0.07549161,0.044630274,-0.008631495,-0.12316091,-0.03968263,0.014747678,-0.0697728,0.036718227,0.060061824,0.034504145,0.008141051,-0.033791516,0.0133059,0.023129595,0.051256027,-0.005964013,-0.08490207,0.04146986,-0.010709815,0.118418664,-0.060670804,-0.043471687,0.015018782,-0.06343521,0.006956367,-0.060456816,0.015230525,0.002780489,-0.053332742,-0.07873411,0.055952642,-2.9900898e-34,0.07384262,-0.11523595,0.08836139,0.0700848,0.118165866,0.02879263,0.0316112,-0.042246465,0.15580893,0.028097598,0.07624906,0.035542104,0.08044455,-0.017633632,0.01033167,0.014386422,-0.11033339,0.0002369436,-0.012889434,0.009826623,0.017857425,0.1355504,0.0349769,-0.027475491,0.001693402,0.026371676,-0.10122093,-0.012166924,-0.0058392296,-0.05174423,-0.051479407,-0.0010608648,-0.09308239,0.0116386125,-0.091951296,0.0065559396,0.010315645,0.029563041,-0.03800389,0.033124067,0.039946083,-0.061016742,0.00983637,0.0997974,-0.0539987,-0.014061634,0.052645635,-0.031148765,0.09139399,-0.02134216,-0.05543604,-0.0018486159,-0.005623624,0.03884311,0.06535405,0.044054646,0.049581528,-0.11430855,-0.00789272,-0.017542966,-0.021932688,-0.0012042831,0.05146769,0.07167032,-0.04090301,-0.03121961,0.057498172,0.037328776,-0.022214813,0.0055572935,0.07345699,-0.06594445,0.047895342,0.057503875,0.028700365,-0.054964047,0.006044219,-0.056497015,0.032776166,0.0040138187,-0.11457703,-0.021089764,-0.0011788576,0.073927276,0.09902271,-0.06377341,0.061326355,-0.056760527,0.01042042,-0.0042069727,-0.054494333,-0.03439931,-0.030581089,-0.013817846,0.00156773,-1.8461803e-08,0.028564341,0.009390762,-0.049220387,-0.08392364,-0.056666873,-0.0019556908,-0.04531196,-0.001519332,-0.042112824,0.057806935,0.009872382,0.14110868,0.032702412,-0.035296265,0.07091759,-0.054143395,-0.01629802,-0.008079705,-0.08583286,-0.074059255,-0.068514,-0.0037480276,0.019274086,-0.053765293,-0.014412682,0.030633513,0.02336382,0.034664255,-0.05515106,-0.01144416,-0.002412544,0.015759636,-0.016337048,0.0085176425,0.055487253,0.09141445,0.019908423,-0.011354619,0.022893906,0.05025292,0.03535717,-0.089506686,-0.06290775,0.060785174,0.006461008,0.03984625,-0.0037312754,-0.027534662,-0.06473911,0.0027940315,0.022352327,-0.044934094,0.03235025,-0.028072441,-0.05962391,0.056774877,0.010317316,0.0069530853,0.105414554,-0.038932268,0.066349976,0.06225969,0.078255825,-0.0256893 +2.3.1.71,"Not identical with EC 2.3.1.13, glycine N-acyltransferase or EC 2.3.1.68, glutamine N-acyltransferase",384,0.99999994,-0.081756055,-0.053643692,-0.10542155,-0.042332526,-0.0154007515,-0.0007523264,-0.10096899,0.051935952,0.0661024,-0.13983409,0.11182777,-0.031422134,-0.053693503,-0.011686077,-0.04397137,-0.059202433,-0.02718956,-0.07885745,-0.031070901,-0.05121413,-0.040341504,0.08612543,0.020669883,0.010459577,0.056844313,-0.043887615,0.006061131,-0.008174815,0.033939697,-0.07837793,0.01608806,-0.085858375,-0.0063133608,-0.05575781,0.1186114,-0.016963627,-0.035872765,-0.032677684,0.07373431,0.003246154,-0.0036610474,0.014837319,0.011014181,0.008752148,0.0031484517,-0.020155484,-0.011388314,0.056327205,0.010821698,0.0125411125,0.055258706,-0.02927495,-0.039508317,0.032485146,0.07070725,-0.010101208,-0.19262992,-0.041013144,-0.028509237,0.06541462,-0.055259448,0.03224852,0.0056953044,-0.039215367,0.013441477,-0.010750468,0.1098104,-0.15053543,0.046248887,-0.033464313,-0.070874885,-0.041236468,0.0051564667,0.01663811,-0.026640907,0.008409542,-0.048040323,0.063534126,0.0062047546,-0.035144936,0.018302936,-0.063173585,-0.021637304,0.007108725,-0.019014694,-0.07879518,-0.01780795,0.088466935,-0.053690337,0.015513667,0.061985046,-0.025494069,0.11092491,0.028409235,-0.014346595,0.04537406,0.014954171,0.10480929,0.025018979,-0.009566185,-0.02650916,0.12384437,-0.04043983,-0.014536099,-0.014488987,0.051526356,0.013655751,0.060793377,0.014538912,-0.027760454,0.0019979773,-0.030970078,0.017680652,0.006971709,-0.06416785,0.08610995,-0.02516818,0.0059110853,0.04570983,0.03552487,0.060018294,-0.060525488,0.054690998,0.07375381,-0.020204568,0.079528436,-0.0052965954,2.612709e-33,0.044893637,0.0027071151,0.037848182,-0.02408285,-0.014816136,0.010899815,-0.151722,0.04832865,-0.015703805,-0.07438159,-0.06954935,-0.058549024,0.023619236,0.010315308,-0.027272958,-8.230612e-05,0.007240331,-0.05198014,0.021761522,0.01358479,0.070114315,0.043632645,0.044756524,0.0071480772,0.03230179,0.0050137127,0.011983998,0.04402658,0.0101771895,-0.011400914,-0.022528803,-0.13554649,0.0010177694,0.02575185,-0.002666777,0.0192342,0.025265785,-0.08563087,0.06413852,0.043128423,0.016630325,0.08158503,0.02552062,-0.07211758,0.08734154,0.03327631,-0.048600305,0.020541428,0.005022394,0.052779872,-0.008366625,0.008509393,0.054510344,0.015432793,0.01918739,-0.041012816,-0.01869865,0.033190347,0.04705426,0.07494278,0.0132852765,0.091058604,0.014620242,-0.05786037,-0.02643316,0.048829082,-0.079023935,0.035709586,-0.029318467,0.036421884,-0.021338811,0.01050136,0.083909854,0.057311546,0.10686664,-0.09819081,-0.05448355,0.067820445,-0.010430805,-0.0084891375,-0.06194325,0.09099645,0.02935705,-0.023298204,-0.08388322,-0.02667269,-0.017576061,-0.04454117,0.041468754,7.925822e-05,-0.0039719464,0.05227877,-0.047198374,0.02979856,0.010648989,-3.241596e-33,0.023124365,-0.02283153,-0.028673587,-0.045281455,-0.036203384,0.01260537,0.009040558,0.033252954,0.04947737,0.006905899,0.0931809,0.018909553,0.008314668,-0.09338817,0.11062722,0.0047271056,-0.02239985,0.051485553,0.0073893415,0.031654276,-0.014698984,-0.010078741,-0.06653164,0.0125126485,0.034699697,0.033612534,-0.015507813,0.04351314,0.069823705,-0.0065504303,-0.047531325,0.043612532,-0.04429445,-0.052026216,-0.047434296,0.00057802,0.017698936,-0.002685925,-0.060370438,-0.028487356,0.06160508,0.09024554,0.017660003,0.045054097,0.050175864,0.1090867,0.024373466,-0.024818227,-0.049523212,-0.05997148,-0.0048833326,-0.00049013196,-0.010494067,0.020650882,0.057707734,0.048013844,0.0791052,0.041854195,-0.008899129,0.0031224291,0.00562724,-0.050778568,-0.013540803,-0.020876566,0.039200816,-0.011454007,-0.04020424,0.044861794,0.031129697,0.087441154,-0.017047407,-0.10941668,-0.022173088,-0.02380814,-0.0031303193,-0.002303659,-0.047268227,-0.023407368,-0.0011662103,-0.07246189,0.012313181,-0.023475653,0.015119012,0.025675239,-0.0010427432,0.04356551,0.03551131,0.05388292,-0.01712897,0.08615229,-0.033746164,-0.010483643,-0.08331845,0.031260997,0.014022656,-2.9236876e-08,0.10850391,-0.04656351,0.019700984,0.004034375,0.027963927,0.061167207,-0.078845106,0.056932636,-0.029964471,-0.00946298,-0.039449025,-0.0053160028,-0.041648638,-0.055882744,-0.09357353,0.028545493,-0.051176883,0.028484732,0.008495081,0.043064937,-0.10696514,0.06910075,-0.015428113,-0.03876276,-0.05197609,-0.014390183,-0.019176703,0.03466381,-0.020306714,-0.0916655,0.03192642,0.016597569,0.039661046,-0.121079065,-0.06454643,-0.068139516,0.042904157,-0.028016461,0.037964676,0.031558696,-0.02970678,-0.031604473,-0.04346931,0.025731936,0.10045002,-0.03797041,0.041873325,-0.045317277,-0.049584992,-0.0048465277,0.03475209,-0.06588471,0.0045095403,-0.09243883,-0.01094515,-0.04700059,-0.1290616,-0.04710854,0.06490607,-0.022033483,0.025143841,-0.051678564,0.1125845,0.057257634 +2.3.1.72,The position of acylation is indeterminate because of the ease of acyl transfer between hydroxy groups.,384,1.0,-0.043725584,-0.10138885,-0.03458341,0.012587652,0.026574288,0.0061434517,-0.027378218,-0.024930656,0.041185662,-0.021784788,0.15955696,-0.0012361344,-0.013864298,0.030586088,-0.03365727,0.03697012,-0.03337251,-0.06028166,-0.05373323,0.012512257,0.011261928,-0.023860773,0.022117881,0.036403093,0.059857544,-0.04128155,-0.019932672,-0.021685604,0.01019013,-0.08803519,-0.06879838,0.08181378,-0.07400261,-0.0019772914,0.031338446,0.039313607,-0.041293584,-0.12333505,0.10413606,0.034930438,0.019362755,0.018317156,0.032875355,-0.04380775,-0.04166931,-0.010669516,0.020181067,0.019343056,-0.0017405952,0.020208653,0.017230902,-0.0074270326,-0.013988699,0.04820192,-0.13079986,0.0026752327,-0.021695271,-0.010756588,-0.050680377,0.023368258,-0.0339619,0.026573874,-0.06625537,0.0484893,-0.061572846,-0.06723956,0.074077085,-0.050783515,-0.014352972,0.075976446,-0.01644442,-0.0728622,0.04109384,0.031850237,0.12579349,-0.040125478,-0.013930826,-0.08604236,0.059962444,0.017388053,-0.008989157,-0.0058682915,0.07556568,0.00075708854,0.011201014,-0.09810389,-0.016693301,0.0055826036,-0.004568186,0.029182479,0.0074863834,0.0064454083,-0.042408176,0.015498244,0.033712655,0.029901244,0.08538277,0.008750841,0.0049778605,-0.020679267,-0.020398775,-0.02528948,-0.014443411,0.007101836,-0.07516769,-0.05341229,0.00095938134,0.032343492,-0.027937712,0.013507056,-0.016832411,-0.026045365,0.0875328,0.046112936,-0.08390468,0.08243493,-0.004121836,-0.027980028,-0.04805116,-0.09339989,-0.05369503,-0.0021579198,-0.017284498,0.10273668,-0.07537167,0.07521846,-0.020749893,2.9875194e-34,0.03983845,-0.010206487,0.016884351,-0.023044981,-0.005443737,0.0069380896,-0.09838504,0.06556658,-0.017996905,-0.009707291,-0.0090709,-0.025523327,0.008712495,-0.028488837,-0.0012080587,-0.041404303,0.01769254,0.08406149,0.01730936,0.014916209,0.08007252,0.09374532,-0.035710238,-0.06762102,-0.10256903,-0.02702454,-0.049534593,0.021606496,-0.07074275,0.009930053,-0.05248231,-0.04656565,0.008926553,0.020118468,0.026882412,0.052869156,-0.0647523,-0.011293148,0.07660975,0.06314411,0.060500074,0.06784336,0.040859103,-0.08059005,0.07007497,0.005735501,-0.026071198,0.07078438,-0.06191941,0.12485829,-0.004752048,0.042106375,0.05957949,0.05524904,-0.008652448,0.009842165,-0.027971089,-0.0018029117,-0.045973454,-0.05906376,-0.031071598,0.043002356,0.0037895937,-0.08698691,-0.033093654,0.021539345,-0.056434438,0.041042704,0.0013717085,0.035691228,-0.039126333,0.0007410813,0.048902884,0.10271679,0.06598261,-0.034492712,-0.034393054,0.055563096,0.055112634,0.0011391513,-0.028445266,0.040209167,0.03510106,-0.0034540647,-0.064879976,-0.08010497,0.008547572,0.045870334,0.027663264,0.10693558,0.06589239,-0.041892674,0.07305556,0.022605453,0.079951115,-2.516813e-33,0.055243306,-0.064012915,0.006980158,-0.042547684,-0.012172673,0.019735396,0.09154423,0.058263198,0.053641703,-0.0011707805,0.08616511,0.12582378,-0.100391045,-0.05102821,0.016917028,0.010376747,-0.018481167,0.05152107,-0.017843531,0.026136855,-0.020337092,-0.0010603595,-0.004496001,0.079692855,0.045661274,0.021910626,-0.024555609,0.023768894,0.06441171,0.106217004,-0.0206371,0.025211783,-0.074028365,-0.0493973,-0.011989251,-0.03327147,-0.12832645,0.09872324,-0.017167553,0.08422791,0.057281043,0.0062027257,-0.028602857,0.030956365,0.10965512,0.02502164,0.0059570265,-0.047169495,0.0045394343,-0.05876301,-0.056776945,0.039496627,0.05762597,-0.019252038,0.0047724512,0.11240096,0.022826975,-0.011579245,-0.00803579,-0.08723428,-0.037173696,0.058490787,-0.008420547,-0.09813539,-0.05364772,0.0049030758,-0.025098462,0.011076169,0.07391436,-0.06352146,0.10252084,0.050565552,-0.024628468,-0.0069785267,-0.008399044,-0.04284603,0.011897458,-0.08778516,-0.06860001,-0.07999627,0.008820102,0.02333586,-0.00074684457,-0.005500736,-0.0615459,0.016369425,-0.014372983,-0.033166744,-0.030395452,-0.015954314,0.033526786,-0.059694346,0.009318341,-0.016302895,0.046409078,-2.6136409e-08,-0.03235642,-0.011268909,0.064555764,0.017606216,-0.07852796,0.106342494,0.037346765,-0.027192365,0.067688085,-0.050937086,-0.0071905083,0.09391818,0.008825936,0.01595646,-0.06419557,-0.016531799,-0.108712204,-0.026208505,-0.049968917,-0.0023625966,-0.14465442,-0.029109543,-0.019941753,0.047995277,-0.06314671,0.016381623,-0.012206464,0.024658231,-0.04166709,-0.07000842,0.02757992,0.012971691,-0.028188528,0.09523997,0.011791603,-0.015201898,0.05450627,-0.0060408637,-0.06588737,0.0093773315,-0.008606023,-0.059079736,-0.012153116,0.044197798,0.07011068,-0.044314295,0.042019077,-0.030554783,0.0128298225,0.03658671,0.06729285,-0.00830305,-0.07729312,-0.03249651,0.0018367991,-0.02664487,-0.07925661,-0.024042148,-0.075072736,0.0019553595,-0.03211481,0.022445774,0.100180015,-0.030149786 +2.3.1.73,"Cholesterol, sitosterol, campesterol and diacylglycerol can act as acceptors. Transfers a number of long-chain fatty acyl groups.",384,0.99999994,-0.055953015,-0.10453965,-0.057582635,0.048371106,0.0068543297,-0.00675282,-0.01724077,-0.04670193,0.011038922,-0.06798067,0.085280165,-0.028224953,-0.06750541,0.0040926007,0.060913354,0.02465368,-0.029406631,0.049861103,-0.0070775053,-0.022744637,-0.070585586,0.028095884,-0.037282065,0.0097891465,-0.087175414,-0.086816706,0.0037976727,-0.02993132,-0.03709878,-0.12091019,-0.015442127,-0.024370596,0.048496615,-0.023159625,-0.013843316,-0.0072127916,-0.0058250525,-0.0019744837,0.011959147,-0.0024563004,0.06657523,-0.091884814,0.035959713,0.021432422,-0.045579176,-0.090062626,-0.012078402,0.055172116,0.03366989,0.008601036,-0.042646617,-0.006654249,-0.04139153,0.089919955,-0.02251486,0.06475443,-0.09153121,-0.05286722,-0.0022207147,-0.02535911,-0.011031832,-0.021368215,-0.032885846,-0.018584946,-0.12918042,-0.036231454,0.011757191,-0.007437496,0.0666867,0.03276043,-0.012744534,-0.07613468,-0.029770255,0.0237677,0.050553396,0.034442008,-0.039600044,-0.049706392,0.12160671,-0.006988183,-0.039793212,-0.031037118,0.047542915,0.05879239,0.08177943,0.015409451,-0.04055499,0.053177208,-0.07390914,0.02782884,0.02651573,-0.036209036,0.04174731,-0.01481701,-0.016911123,-0.07752616,0.102387816,-0.038685523,0.011494156,0.0032070086,0.0065468433,-0.0045552845,-0.015489967,-0.035545975,-0.10901876,-0.03156964,0.022955503,-0.03538036,-0.018362587,-0.031226747,-0.07434396,-0.0412337,0.07995549,0.020338794,-0.08661082,0.005661717,-0.002979,-0.10556171,-0.00072121184,-0.006245167,-0.05046034,0.029582154,0.044152077,0.002058728,0.022962747,0.032497924,0.007607886,3.6323473e-33,-0.047048133,0.036496446,0.010739422,0.018112581,-0.004433437,0.0067466362,-0.09181882,0.019115442,0.024936028,-0.03579011,-0.03548245,-0.031159833,0.025547508,0.14790916,-0.011786437,-0.04433646,0.0005870247,0.07795012,0.10322591,-0.055762,-0.040490072,0.10215964,-0.040238846,-0.03483526,-0.011504179,0.028604763,-0.04903271,0.030860577,0.030386329,0.02482696,0.07162912,-0.07655559,0.013113071,0.06180816,-0.007949124,0.115675375,0.010770318,-0.03967068,-0.05721703,0.0037324892,-0.003503371,0.033945158,-0.0812243,0.035462767,-0.019976366,0.00046478063,-0.057694282,-0.009661456,-0.011365362,0.059950676,-0.013056264,-0.011657571,-0.015860584,-0.008604419,0.009345997,-0.016325908,-0.035748072,0.107321694,-0.010253738,-0.0066097574,0.007327691,0.10891108,-0.043846138,-0.01641774,-0.035514764,0.019739343,-0.09372676,-0.04608744,-0.055434443,0.04042809,0.046715625,0.026668977,0.00043427182,0.09708854,0.057897806,-0.012058038,-0.050717812,0.041437905,-0.024769505,-0.01247909,-0.03595857,-0.06482227,0.013802695,0.03273651,-0.07935588,-0.03603859,-0.043630503,0.00027941426,0.06404439,0.001873868,-0.019564932,-0.01634909,0.012793638,0.07282982,0.07982002,-4.6486188e-33,0.026376497,-0.053955764,0.097190365,-0.011012226,0.00114197,0.06120648,0.028358089,-0.09007783,0.15528208,-0.027881969,0.03871551,0.040967267,0.050574727,-0.048796497,0.019217862,0.04622717,-0.027025053,0.032358125,-0.043461166,0.0031609589,-0.054657314,-0.0022122539,0.008817851,0.16021787,0.021560306,0.07817656,-0.011028846,-0.003696592,0.047456663,0.056562487,0.040510807,-0.024515443,-0.008060837,-0.08028604,-0.0201828,0.025764272,-0.10028352,0.08691921,-0.08425902,0.02464962,-0.014444837,-0.031253252,0.01711431,0.01645718,0.02001524,-0.025538873,0.037731912,-0.046547074,-0.0040854826,-0.063109584,-0.046530996,0.033782512,0.019352363,0.008597993,0.09989497,0.15788484,0.081481926,-0.06956391,0.05570709,-0.11397914,-0.05386946,0.0041848468,0.040297158,-0.04637063,0.049612895,-0.040980652,-0.012540684,-0.07132369,0.013586293,0.016603231,0.04997285,0.047768842,0.0119157,0.07165651,0.027965983,-0.015689809,0.0060662837,-0.05711815,-0.05532033,-0.043817073,-0.06513715,-0.04324543,0.048428386,-0.050738905,-0.025683533,0.0007027931,-0.016181633,-0.0076119835,0.022845106,0.042294554,0.05295646,0.0009373858,-0.027819429,0.028010968,0.02194069,-3.2664936e-08,0.06410509,-0.09908291,0.011126672,-0.0119098965,-0.13476895,0.01069233,0.0037761042,-0.007007101,0.012280292,-0.017856428,-0.009617104,0.19325525,0.08810774,-0.019817838,0.052430484,0.01624554,-0.021331403,-0.013276998,-0.013363281,-0.0048634494,-0.094304346,-0.017015234,0.028237108,0.008672349,-0.013226579,-0.01643513,0.0025779952,0.037930246,0.033167165,0.013582292,0.05592965,0.027109629,-0.020708188,0.039336275,0.07921223,0.059432317,0.045064785,-0.034294225,-0.04824053,0.1542847,0.06371473,-0.019208254,-0.075330555,-0.003556472,0.001634731,-0.028446358,-0.042750154,0.017858846,-0.037886053,0.013345238,-0.014636895,-0.0077779526,-0.004368773,0.02386221,-0.018571014,0.017316444,-0.04623591,-0.029785844,0.0015840236,-0.026230095,-0.021966748,0.016548963,0.1540293,0.029120225 +2.3.1.74,"The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.",384,0.99999994,-0.086566485,-0.027018817,-0.08329556,0.034007493,0.07268381,0.10508681,-0.07323311,0.0189925,0.03669019,-0.00080779346,-0.017864082,-0.03219727,-0.09042304,-0.05906653,-0.052687842,0.030613758,-0.08610784,0.041131265,-0.06323755,-0.05191685,0.114276044,-0.047417372,0.015692096,-0.019751348,0.01738278,0.026258301,0.04228924,-0.029464802,0.065154776,-0.076867834,0.056139935,-0.0022761053,0.061935432,0.011623058,-0.070367865,0.103155546,0.0007047373,-0.103125475,0.058880024,0.019386858,0.06422105,0.03381333,-0.025138631,-0.022573706,0.043332435,-0.07115301,-0.03366249,0.052131593,0.0037752062,-0.0038281213,-0.07476171,0.018240161,-0.07064982,0.0065536764,0.013147024,0.05108719,-0.0133210765,-7.642978e-05,0.049452998,0.06650825,0.045367945,-0.049182724,-0.024921753,-0.01053039,-0.0011858618,-0.08547076,0.009143036,-0.012421031,0.057281025,-0.010797579,-0.013950203,-0.020228038,-0.057613064,0.030623196,-0.0067608072,0.06056398,-0.023709796,0.054783072,-0.07203863,-0.010546559,0.04738547,-0.030844843,0.052210018,0.06075128,0.028431974,-0.038445275,-0.07091671,-0.00075696094,0.091202304,0.09032026,-0.03370569,0.021870779,-0.014155864,0.022219362,-0.06498494,0.098366424,0.05658349,-0.021643968,0.038267303,-0.017621303,-0.012793556,0.0025820427,-0.0010874475,-0.049830366,-0.037534732,-0.050300054,0.009395493,0.044584446,-0.0032365432,0.008759818,0.019729158,-0.04650178,0.047673237,-0.046810478,-0.031238556,0.10501634,-0.041089293,-0.05683906,-0.044689845,-0.002840778,0.030873125,0.01074641,0.047570627,0.0785024,-0.07037658,-0.030381491,-0.08689643,1.16263545e-33,0.11159917,0.050404143,-0.019397942,0.027710333,-0.0021820485,-0.04811663,-0.03517988,0.021527791,-0.0014163837,-0.08659732,-0.027100785,-0.024747085,-0.0036940326,0.0041822027,-0.025082601,-0.06685402,0.019936932,-0.08226618,0.008141383,0.009906245,0.014668234,-0.014624598,-0.06434939,0.08497164,-0.0181253,0.01862967,-0.02686331,0.030930687,0.038939048,0.004173033,-0.0291154,-0.10871866,-0.026241926,-0.014317554,0.02188008,0.01235847,-0.092338294,-0.06598316,-0.04431735,0.06030989,-0.0039111353,-0.04844266,-0.07602219,0.03290436,0.01034327,0.03858742,-0.08370664,0.058692887,0.071065105,0.09779663,0.021050932,0.021302879,0.12803574,0.08215435,-0.10779435,0.067254454,-0.029719152,-0.11037144,0.010265265,0.032424636,-0.017589558,0.0002848726,-0.0045332457,0.10757791,-0.046706975,0.0110869445,0.0052124523,-0.033371072,0.01889103,0.038802806,-0.067656,-0.06595472,0.078878045,0.0027551376,0.09050241,0.026323626,0.0013292471,-0.050377075,-0.027667135,0.0074182446,-0.029821852,0.041131895,-0.0032337324,0.031518355,-0.040264927,0.013361197,-0.052299406,-0.045191653,0.014434941,0.0031171944,0.02065839,-0.066131994,0.04923643,0.06256969,-0.0026376501,-1.6593396e-33,0.0721522,-0.08124627,0.057788957,-0.0030802158,-0.05120958,0.06005393,0.009122594,-0.10661535,0.011366813,0.025062209,0.011381636,-0.07742851,0.0005024054,0.012016524,-0.001604469,0.056581385,0.068880856,0.09296118,-0.013184929,0.04954526,-0.021252334,0.03769294,-0.0037296882,0.03950377,0.066071615,0.03732232,0.07118847,-0.042594656,-0.026697127,0.06965417,-0.025036512,-0.022248235,-0.04578465,-0.009057563,-0.021924818,0.062241405,-0.023650108,0.0058570057,0.00017466451,0.046083912,0.011273638,-0.013894569,0.017260369,0.012705589,0.04357338,0.026525669,-0.04012084,0.0408475,-0.045000155,-0.049924344,0.07988074,0.13055556,-0.03445889,0.057883613,0.020518592,0.01112577,0.06239219,0.011773584,0.046272427,-0.002433777,-0.047829013,-0.110973716,0.058138013,-0.0107271895,0.034163505,0.06914756,0.03228017,0.1269153,0.017121183,-0.026916225,0.06345334,-0.013358422,0.052900746,0.12387815,0.004756485,0.00073514954,-0.06379146,-0.08031025,-0.08562029,0.008858609,-0.01071448,-0.01964462,0.032615647,-0.12295624,-0.06664505,-0.0813844,0.02186586,0.031638358,0.0066405726,0.04664771,-0.050896745,-0.028839601,-0.012663527,0.039311677,0.015531108,-3.0349142e-08,-0.02870943,-0.057845578,0.041102473,0.046657324,0.058135625,0.033015292,-0.016212475,-0.02974906,-0.020478735,-0.024575885,-0.089115344,0.04169665,0.00850235,0.030909317,0.027537255,0.0020586927,-0.015163971,0.008911664,-0.013043827,-0.011202545,-0.073170625,0.026483616,-0.11100118,0.019242665,0.014523025,-0.08836319,-0.020086644,0.06488952,0.0787701,0.021771252,0.039397962,0.06561406,0.025613688,-0.0055641276,-0.14494553,-0.0267295,0.05940311,-0.0460351,-0.024269678,-0.0011623387,-0.05496151,0.029733235,-0.021695763,0.0057695415,-0.07805978,0.017039478,-0.007101824,0.049635045,0.018393936,0.0058543645,0.013018136,-0.0011543127,-0.020744335,-0.03142763,-0.08069944,-0.047095947,0.02337689,-0.045172185,-0.031355612,-0.09141182,-0.038322967,0.027177146,0.19083478,-0.0103002 +2.3.1.75,"The enzyme transfers acyl residues from acyl-CoA to long-chain alcohols, forming wax esters. Wax esters have diverse biological functions in bacteria, insects, mammals, and terrestrial plants. The enzyme from the plant Simmondsia chinensis (jojoba) prefers acyl residues of chain-length C18 to C20 and its preferred acceptor is (11Z)-icos-11-en-1-ol. cf. EC 2.3.1.332, medium-chain-alcohol O-fatty-acyltransferase.",384,1.0,-0.09079177,-0.0066264826,-0.040592097,-0.013892128,0.03902733,0.08371078,-0.08500215,0.023710608,0.029031727,-0.0041402993,0.114615105,-0.058620896,-0.13764411,-0.029523347,-0.034784753,0.08389518,-0.0613256,0.04209989,-0.07600164,-0.09918636,0.092874624,0.017355556,-3.122097e-05,-0.008144154,0.04235636,-0.104853556,-0.032604635,-0.02437669,0.0053671016,-0.0738029,0.012171194,-0.012741685,0.049505953,-0.086983785,0.032415126,0.008829667,-0.021916362,-0.1590921,0.15249035,-0.0022272358,0.07568896,0.012783497,-0.026623752,0.015656572,-0.037342183,-0.026866458,0.037376538,0.0493003,0.043473333,-0.000865048,-0.022689816,-0.07391766,-0.04801333,0.044269912,-0.029463232,-0.017203849,0.01715232,-0.018697962,0.018272543,0.082520396,0.024435071,0.028543646,0.025135735,0.016850373,-0.077322595,-0.06504928,-0.028308999,-0.032905467,0.017040424,-0.039176412,-0.0749977,-0.099696204,-0.021348942,0.020277381,-0.007941929,-0.004155505,-0.050179113,0.0022093265,-0.011899165,0.024195755,-0.029470192,-0.03958593,0.066147305,0.017279226,-0.021540374,-0.050095208,-0.031997465,0.025994388,-0.005636615,0.081281796,-0.010491253,-0.03920638,-0.019870507,-0.03589362,-0.052030265,0.0043956838,0.108071685,0.032130677,0.020905545,-0.009082335,-0.015966969,0.05658471,0.023165694,-0.15044338,-0.104246214,-0.029424885,-0.029883273,-0.013766972,0.029198606,-0.0013296466,-0.03339717,-0.011598316,0.009342172,0.005792233,-0.07490014,-0.030261599,-0.059009153,-0.052608237,0.005292919,0.024890061,-0.0046408223,-0.033350978,0.0037983041,0.092888705,0.049472626,0.026200322,-0.110345565,-1.7686393e-34,0.057218723,0.06486293,-0.026752936,-0.002289515,0.008950471,-0.056137815,-0.05535564,0.021046653,-0.10658679,-0.010386098,-0.09117093,-0.043493,0.008478047,0.032007664,0.0331743,0.047631327,0.039475784,-0.0154257035,0.1021558,0.021229269,0.0062206737,-0.019402787,-0.055111058,-0.019732162,0.05701354,0.07383117,-0.039824445,0.017349692,0.0011782862,-0.0007964898,0.051117368,-0.008580409,-0.0018757654,0.06236568,0.054761842,0.06013965,-0.01694313,-0.045872547,-0.08610577,-0.0010705169,0.07591265,0.031847533,0.05146287,-0.008138609,0.025733417,-0.02520872,-0.13946658,0.024547316,0.10763789,0.09309937,-0.009685288,0.039025888,0.12586619,0.06917557,-0.0064895116,-0.019416228,-0.05174572,-0.00408514,-0.027479917,-0.017617298,-9.098781e-05,0.022903997,-0.048671033,-0.031962577,-0.0030783643,0.052255042,-0.09502684,0.012518192,-0.059228085,0.010680697,-0.031941503,-0.031671066,-0.0098038,0.034164947,0.027806139,-0.0042430586,-0.08412283,0.019231824,0.034693107,-0.0074315877,-0.027969353,-0.020404406,0.045942713,-0.08108678,-0.04522756,-0.08139067,-0.06344153,0.058184803,0.037084144,0.023917729,0.016801177,-0.0011290144,0.008639103,0.11789314,0.01713365,-2.001386e-33,0.087515034,-0.062180676,0.035319228,-0.058995258,-0.025175026,0.09491889,0.01592282,-0.011606733,-0.0215815,-0.031691123,0.06324897,-0.00687867,0.033558745,-0.037239905,0.04930066,0.029858042,0.017627668,0.08094124,0.030505756,-0.023709912,-0.030039145,0.061847202,0.032672744,-0.0062588556,-0.034326114,0.013396559,0.006369585,0.04081272,0.0027549884,0.06202445,0.0011604935,-0.026029872,-0.019534754,-0.05266333,-0.020009542,0.012290127,-0.060615987,0.003822742,0.02671525,0.11470118,0.08628861,-0.048870195,0.009024962,-0.0047173817,0.03955485,0.009852086,-0.07123547,-0.024497801,-0.00521258,-0.04956898,0.06907183,0.008735656,-0.008261135,0.011794757,0.05849246,0.12002045,-0.0037181368,0.033248562,-0.016544905,-0.12104059,-0.058220465,-0.017941473,-0.013536914,0.06969551,-0.02557995,0.07233212,0.0034248584,0.017076816,-0.009726954,-0.009626928,0.040403113,0.06155446,-0.013071175,0.07994811,-0.04680259,-0.06736154,-0.032730892,-0.07523283,-0.039928272,-0.0058048544,-0.039518114,0.005526138,0.008005572,0.0020347117,-0.008148645,-0.05364634,-0.04194598,0.005886141,-0.005578046,-0.004096881,0.013211704,0.050314825,-0.024439579,0.044230483,0.046768095,-4.0100247e-08,-0.023892635,-0.03414351,0.05261285,-0.02360709,0.0042229732,0.03450646,0.032569155,-0.009182235,0.0026657132,0.032229308,-0.019918714,0.10619861,0.053591795,0.017514607,0.05043518,-0.04531895,0.03645411,0.0564269,0.0037021015,0.004623783,-0.1121336,0.01971734,0.0143703045,0.0006255069,-0.009603228,-0.069148056,0.05262156,0.10271798,-0.011616567,0.051643483,-0.032265216,0.07680296,-0.025780896,0.009480781,-0.051523153,-0.022730242,0.04228708,-0.10416805,-0.05257801,0.07977776,0.03937583,-0.04491397,-0.0948741,-0.014895752,0.10428466,-0.044155758,0.07614301,0.019557983,0.0035535076,0.057113696,0.07620781,0.049318064,-0.02646908,-0.030196,-0.011960335,-0.05508056,0.01459927,-0.023169735,-0.045198884,0.01483948,0.06501479,-0.022483423,0.16805981,-0.08646511 +2.3.1.76,Acts on palmitoyl-CoA and other long-chain fatty-acyl derivatives of CoA.,384,1.0,-0.08493875,-0.10187937,-0.026933007,0.036672175,0.040259264,0.026272988,-0.13761595,0.009307207,0.019674985,-0.028474385,0.077505715,-0.06464746,-0.07376175,0.0052766223,0.0661763,-0.027980722,0.0047192504,0.004781612,0.013836606,-0.038626064,0.014225214,0.039437942,-0.013141652,0.014187036,-0.0049108393,-0.02247888,0.052745666,-0.04574484,0.01060288,-0.06513764,0.014031243,0.021785224,0.03139562,-0.07253129,0.00053356617,-0.032514147,-0.027836947,-0.0323014,0.028163392,-0.029056948,0.08292359,-0.13545258,0.04491556,0.022199877,-0.051085558,-0.1258035,-0.022546683,0.059116542,0.035233304,0.06331289,-0.022603637,-0.015955435,-0.08286047,0.038179684,0.014766215,0.025057282,-0.06386,-0.010481872,-0.010569314,0.045196503,-0.001070572,-0.018989976,-0.043579515,0.06711588,-0.052295044,-0.051473282,0.055621848,0.00529536,0.045619868,-0.004249962,-0.00084018795,-0.08668298,0.0036449875,0.013454665,0.0270347,0.038519964,0.0046824156,-0.060790464,0.02052465,-0.01692589,-0.029153965,0.06793929,0.06962587,0.06652713,0.0058171037,0.0019017839,-0.01169066,-0.02033847,-0.072551616,-0.010493395,0.08186267,-0.08721612,-0.00040821044,0.026148709,-0.09874055,0.09332508,0.028855389,-0.032137528,-0.026370425,-0.006342994,-0.0342932,0.05138416,-0.064873576,-0.056527175,-0.041960202,0.014833919,-0.038230296,0.009301128,-0.007061606,0.015653228,-0.021991093,-0.0050118873,-0.01439006,-0.032179672,-0.04991711,-0.036478337,-0.007921694,-0.01586048,-0.010414439,0.042966727,-0.03480501,-0.034698453,0.007384462,0.036356483,0.027747346,0.010448759,0.014911329,-3.1316554e-33,0.0238281,-0.017892394,0.027275564,-0.0016189193,0.054744143,-0.11729224,-0.03430148,0.016089939,-0.08061822,0.064757094,0.06409931,-0.013621302,0.0022984133,0.10727399,0.04225467,-0.011353524,-0.012132845,-0.0024592334,0.07271019,-0.050430875,-0.009289424,0.11383176,0.06198539,0.012082609,0.032078184,-0.027488684,-0.012145564,0.08648421,0.037382312,0.040080845,-0.0365475,-0.0080349,-0.02325173,-0.00744366,0.014009434,0.0108144125,-0.07249519,-0.05486429,-0.050793484,0.06525713,0.08448102,-0.0077797794,-0.093537755,-0.058261156,-0.0009430218,-0.048451092,-0.02183735,0.046027068,0.0042978344,0.044733685,0.07267493,-0.00042172696,0.047386475,0.07001258,-0.051443104,0.04210829,-0.08787611,-0.028271668,-0.00644599,-0.05739279,0.010692791,0.025009202,-0.036322396,0.030554974,-0.025801644,0.016727328,-0.10993736,-0.020406183,-0.036997594,0.008394613,0.0707391,-0.03625596,0.03142911,0.0355564,0.064307295,0.0024975778,-0.04368752,0.10585424,0.053828087,0.03572754,0.07116505,0.016126364,0.08318836,0.010796695,-0.0066705593,-0.0033154828,-0.066210836,-0.029181868,0.08457986,-0.0008101738,0.003430914,-0.0072113383,0.04758239,0.012198238,-0.0038715678,1.6287971e-34,0.07060835,-0.07002293,0.026556294,-0.11798373,-0.05513894,0.014048173,-0.01788222,0.013120538,0.040826704,-0.03954332,0.0746253,0.037189707,-0.066034555,-0.09332215,0.015076642,0.057731662,0.043887157,-0.011811789,-0.063360564,-0.018661967,-0.020750556,-0.019048661,0.025145449,0.0630985,0.039641537,-0.0052731764,0.035962027,0.018073505,-0.037332628,0.092096925,0.026222868,-0.016206399,-0.026537053,-0.007725234,-0.028221322,0.0058931555,-0.056450237,0.082940914,-0.046995852,0.031049976,-0.029071469,-0.02385016,0.090957634,-0.07561764,0.08203904,-0.097094394,-0.052524272,-0.059630487,-0.05481829,-0.08541161,-0.010225773,0.012817991,-0.00018247757,0.022366595,0.016644219,0.094991945,0.022774065,-0.029381625,0.10851421,-0.11613759,-0.04181629,0.02953827,-0.012780013,-0.07162239,0.10422384,0.05601684,-0.024122272,-0.052932713,0.0150569,0.014607736,0.032809496,0.053311974,0.026246231,0.020004494,-0.0154361185,-0.03398486,-0.022308832,-0.07741964,-0.095566176,0.014588917,-0.0068814033,-0.069931865,-0.07369477,-0.0354712,-0.11920858,-0.00064253004,-0.003352857,0.0136296265,0.042890523,0.051417165,-0.02659603,0.00062638335,0.010553088,0.03811975,0.06718901,-2.1681798e-08,0.0504719,-0.07698077,-0.020197984,0.015156931,-0.026570916,0.03681305,-0.027391104,-0.050770197,0.033995375,0.0036016672,-0.032644108,0.13311279,0.09366898,0.05457032,-0.016143892,-0.021171233,0.018594338,-0.020640437,-0.021640487,-0.072121434,-0.10430258,0.025737237,0.07974578,0.072640255,-0.027276319,-0.024230288,0.026291976,-0.002893054,0.039127626,0.047607973,0.028113425,0.035419177,-0.019962667,0.031913403,0.070341446,0.0039227377,0.11968205,-0.075951345,-0.0534598,0.17566575,0.05248022,0.011854792,-0.014874001,0.029478574,0.058303893,-0.040779408,-0.030704644,0.10795727,-0.03650475,0.012846716,-0.0070468625,0.05631809,-0.15149443,-0.013186537,-0.04192174,-0.07516787,-0.022774003,-0.039680786,0.027174965,-0.016629206,0.00913787,-0.044617318,0.13447462,0.0026267723 +2.3.1.77,"Tripalmitoylglycerol and, more slowly, other triacylglycerols containing C6 to C22 fatty acids, can act as donors. The best acceptors are 3beta-hydroxysteroids with a planar ring system.",384,1.0,-0.028035637,-0.023130776,-0.06779289,-0.052937996,-0.05336176,0.01661979,0.0046665566,0.041859552,0.010765383,-0.07071645,0.006112884,-0.08718852,-0.13705759,0.0008712685,0.09678567,-0.009584291,0.0046763574,0.059038054,-0.0013303573,-0.03293509,-0.0036698035,0.009039336,0.036638495,0.023361674,-0.062042583,0.027611509,0.036885194,-0.007048106,0.024051178,-0.051241074,0.005901101,0.035678994,-0.060324818,-0.012712345,-0.02361171,0.03670304,-0.09685173,-0.014627457,-0.07229042,0.08116798,0.056581855,-0.022669725,0.025274947,0.023140201,-0.02497424,-0.061611585,-0.052226935,0.10262398,0.034707934,0.04188813,0.027671872,-0.05205355,-0.0050998405,0.033536483,0.017536176,0.026602525,-0.07945729,0.009847808,-0.017421791,0.027459146,0.05226166,0.030644927,0.008799176,-0.015896203,-0.06457308,-0.026264675,-0.004930783,0.005908513,0.06799112,0.0304606,-0.03882416,-0.056760967,0.05901888,0.0566472,-0.036488675,0.044248458,-0.032335814,-0.029333543,0.046125732,-0.031484406,-0.03920223,-0.05936894,0.03850806,0.11369199,0.034653224,0.01558758,-0.047047354,0.021799592,-0.018468935,0.038282987,0.02870397,0.045059048,0.010282012,-0.046576153,-0.071407095,-0.0117780585,-0.0050241607,-0.10864839,-0.03286657,0.008517601,0.017307889,0.0052741915,0.000112119145,-0.076552086,-0.013118986,0.07060396,-0.050525755,-0.041349947,0.08291598,0.008630103,-0.056466173,0.016451126,0.09688417,0.01209885,-0.087917626,0.05837215,-0.049517717,-0.0754391,0.004126579,-0.037511174,-0.008356202,-0.065842845,0.04992193,-0.073135264,-0.031756032,0.054757226,-0.02695891,4.498802e-33,0.028989615,0.05994583,-0.01876877,0.044772416,-0.087226234,0.036053736,-0.040844355,-0.0156918,-0.084400155,-0.080568075,-0.04843478,-0.022011982,0.0440753,0.12379828,-0.014024727,-0.0943603,0.0058463467,0.064837016,0.08491487,-0.063579746,0.01883255,0.02887006,0.0025176983,-0.030962193,0.052632406,0.048660625,0.03253647,0.01631683,0.10633084,-0.0016608014,0.005780584,-0.0070047514,0.09460383,-0.001572571,0.01400193,0.03968545,0.01723557,-0.048636287,-0.034641143,-0.0095979,0.054344688,-0.0016513856,0.020225398,-0.0072317575,0.03411074,-0.003656261,-0.05066876,0.0015436006,0.020547535,-0.016519783,0.024062479,-0.0072482806,0.016987856,0.020963158,-0.048390765,-0.0460969,-0.062747434,0.061042905,0.03419583,-0.02917047,-0.050759885,0.13909352,-0.028698042,-0.010494709,-0.03558432,0.01733767,-0.06724575,-0.1116967,-0.1430287,-0.05477454,0.015551077,0.026266787,0.08075155,0.05562812,0.040737644,-0.0243401,0.043938667,0.033646494,0.005603554,-0.047401335,0.021861445,-0.012050552,0.057020616,0.021263506,-0.007587862,-0.026013907,-0.087584816,-0.07817212,0.04081992,-0.045809835,-0.059846207,-0.03962544,-0.039449926,0.03144991,-0.017903846,-4.553651e-33,0.02172528,-0.07922498,0.08561756,0.00087165064,0.10778949,0.03378716,0.080734186,-0.13498123,0.12050598,-0.021656524,0.046595313,-0.0049041924,0.068985395,-0.0769132,0.084285855,-0.012536309,0.004555803,-0.0062924097,-0.069681264,-0.0614715,0.052201226,0.040562686,-0.028206602,0.07144041,-0.025955938,0.0713456,-0.06024227,-0.00951874,-0.0027660201,0.0424278,0.019194722,-0.041158766,-0.03780131,-0.09163537,0.0051502436,0.043738082,-0.06925919,0.03965819,-0.006870191,-0.0018698481,-0.058487676,-0.06555436,0.0640909,0.053943783,0.0510613,-0.046974562,0.0025898162,-0.00957796,-0.009370336,0.003679487,-0.06711409,0.0057570455,-0.057232376,0.07521363,0.10302461,0.05021943,0.07309389,-0.13261649,0.04870363,-0.05299207,-0.06833722,-0.040991735,0.05147788,0.024103034,0.047972262,0.03905629,0.055018265,0.00049188023,0.03590817,0.059702385,0.061509952,0.055321664,0.00043645292,0.08394878,0.010721682,-0.051271487,-0.0028404456,-0.02131359,-0.015469738,-0.037929952,-0.0034788295,-0.0048477673,0.07202828,-0.048258796,0.07400259,-0.061813246,0.026893025,-0.06169408,-0.02118463,0.070915736,-0.013886349,-0.06037853,0.022720939,-0.0047321753,0.10106217,-3.4721854e-08,0.05756131,-0.020259297,0.021218816,-0.023985762,-0.056957208,-0.04343188,-0.02832126,0.053230755,0.051076002,-0.11947165,-0.0017496573,0.09545192,0.026912818,-0.008581506,0.05379185,-0.03306017,0.02298999,0.042205133,-0.0543083,-0.1001609,-0.067358576,-0.031755656,0.019353753,-0.039586026,-0.035771262,-0.013763531,0.040738344,0.009738127,0.022194522,0.06542135,-0.0011584456,0.013276028,-0.008524384,0.035298146,0.095031545,0.077058606,0.0061723525,0.065305576,-0.061665125,0.1273121,-0.01596149,-0.02216084,-0.064423926,0.045374412,0.019450728,-0.076505885,-0.010335027,-0.0134487,0.03669515,0.009603809,0.006209798,-0.016383704,-0.026638476,-0.051661316,-0.040572774,-0.049892206,-0.082742006,0.020071497,0.035429765,-0.043202683,-0.06242465,-0.014109741,0.10388934,0.040988266 +2.3.1.78,Brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed. Also acts on heparin. Not identical with EC 2.3.1.3 glucosamine N-acetyltransferase or EC 2.3.1.4 glucosamine-phosphate N-acetyltransferase.,384,1.0,-0.059256833,-0.051521692,-0.054568015,-0.047095306,0.05171142,0.043922875,-0.05235317,0.026356075,0.05529715,-0.06651061,0.080461584,0.04335764,-0.020296097,-0.03035712,-0.04210947,-0.07596476,-0.01463608,-0.026016604,-0.04107302,-0.11284951,0.061798006,0.00013265148,-0.026102938,-0.057643432,0.029725404,0.0434138,0.0036523545,0.03794754,0.015627077,-0.08982391,-0.009486678,-0.050130937,-0.008964594,-0.049219325,0.048708178,0.042162582,-0.016707307,-0.0589005,0.008574748,0.00087227015,0.037973113,-0.012011736,-0.026667384,-0.06939474,0.028701842,-0.05081396,-0.013892487,0.030075831,-0.026543591,-0.0260043,0.026231285,-0.055765275,0.052704163,0.049493905,0.053169087,0.0018046584,-0.13591957,-0.019925568,-0.016326223,0.0025430918,-0.026336549,0.06722248,-0.031669587,-0.040536195,0.03932186,-0.015876632,0.12113783,-0.14447725,-0.022357417,0.035057027,-0.06499639,0.021602929,0.057733156,0.07323464,0.075917415,-0.033696435,-0.060587514,0.028094826,0.0074175983,-0.040935148,0.026951864,-0.007984832,-0.044110812,0.08818633,-0.05828511,-0.033423107,-0.068140626,-0.01649635,-0.0037479538,0.031184703,-0.012182708,-0.07492882,0.0139147295,-0.02537732,-0.02837157,-0.011125292,-0.0028706004,0.12715429,0.007736988,-0.0064334585,-0.008745481,0.091171294,-0.09347247,-0.051805016,0.012144105,0.052235313,0.0046961005,0.124243565,0.04172159,0.027107295,-0.037222236,-0.043646798,-0.02009843,-0.03702973,-0.09599396,0.09724254,0.023189992,-0.03711248,-0.0055564274,-0.013459325,0.04290248,0.004593885,0.031238975,0.0867952,-0.0170819,0.0059965397,-0.054964934,4.2479688e-33,0.06541423,0.031447224,0.07721757,-0.055632595,-0.03064218,0.038348805,-0.11043153,0.037292626,0.09596861,-0.108378276,-0.116295174,-0.018526336,0.01991571,0.01623401,-0.022741465,-0.00047180752,-0.050651662,-0.014305113,0.05926879,-0.050575104,0.071407326,0.081107944,-0.077969074,0.03259187,-0.01821237,-0.025975514,-0.02364956,0.024849527,0.024692595,0.011644779,0.01976928,-0.02581363,0.007571236,0.032520644,-0.04757075,0.013469238,-0.005140162,-0.059796557,0.05392184,0.025847698,0.06620101,0.09143035,0.05195106,-0.046580214,-0.032929692,-0.103747375,0.011426172,0.03217766,0.08059265,0.03073882,0.049759347,-0.004243815,0.13594852,-0.060972247,0.004181904,0.029855197,-0.0020502976,-0.007101351,0.0040952414,0.08306269,0.021440411,0.019305022,-9.061844e-05,-0.034467883,-0.006394294,0.040698376,-0.028905516,-0.041403353,-0.055377424,-0.009962308,-0.12366196,0.008439381,0.06157822,0.07428016,0.04889423,-0.04995063,-0.054447718,0.09636758,-0.00072750554,-0.039216787,-0.060546216,-0.032880902,0.014262359,0.05065004,-0.04381281,0.036330745,0.04063048,-0.08219573,0.033173714,0.04740661,-0.02939584,-0.03862994,-0.10108748,0.023977475,0.047532495,-6.623152e-33,-0.004910889,0.01361776,0.0013742325,0.03203059,-0.03969984,0.039165474,0.0108747715,0.05967962,0.03451633,0.01634569,0.07986234,-0.0060931966,0.018352428,-0.06658317,0.015931908,-0.009127417,-0.041966822,0.054438915,-0.011040995,0.047107354,0.006961941,0.029857146,0.037302382,0.02062413,0.04261816,-0.026929466,0.040736847,0.015304209,0.033240575,0.06761506,-0.046220157,-0.018026534,-0.070552126,-0.052074317,-0.042542927,-0.0073746177,-0.032553297,-0.011003029,-0.030744392,-0.06255219,0.040393565,0.016363561,0.04202568,0.059037786,0.055413388,0.12832692,0.0100835385,0.0477284,-0.060905233,0.011787121,-0.05026777,0.042319257,-0.029527258,0.056332476,0.052106094,0.02110717,0.05504617,0.00022748305,0.014241382,0.018439546,-0.04698482,0.02104667,-0.028082803,-0.08103827,0.05960303,-0.03632143,-0.052825294,0.040120162,0.040087584,0.025128713,-0.029925479,-0.13856617,0.069613665,-0.021086596,0.0052647176,-0.067428984,-0.065138385,-0.051454335,-0.058325894,-0.064327486,0.030605834,-0.027266629,0.037999187,-0.058349717,-0.012944081,0.060448676,0.013879169,0.07289633,-0.02914866,0.060427636,-0.03013658,0.026111752,-0.07166815,-0.0116388835,-0.055566892,-3.786212e-08,0.09732094,0.01797156,0.06481503,0.004365134,0.00047202525,0.032928754,-0.029020846,0.093687944,0.00011048117,0.027459757,-0.00608038,0.08198988,0.0039535062,-0.08977522,-0.076997064,0.022606743,0.00014087842,0.043342687,-0.008375062,-0.03471261,-0.1495071,-0.04500151,-0.00832987,0.019163528,0.06196401,-0.03548975,0.010698312,0.011926116,-0.008350907,-0.05315924,0.013535917,0.018256912,0.030578498,-0.10070827,-0.059065178,0.019888595,-0.05236997,0.021588981,0.058705032,0.0035368765,-0.008882987,0.02272001,-0.055098105,0.07664295,0.06056354,0.009721939,0.052897297,-0.003168095,-0.051891565,-0.03269441,-0.0322144,-0.06605803,-0.009711268,-0.11636674,-0.05221444,-0.061465915,-0.04301693,-0.082290076,0.13939485,0.010828563,0.017611988,-0.006734749,0.0937618,0.06093679 +2.3.1.79,"Not identical with EC 2.3.1.18, galactoside O-acetyltransferase. The acetyl group is added exclusively to the C6 position of glucose and to the C6 position of the non-reducing glucose residue of maltose [3]. Other substrates of this enzyme are glucose, which is a better substrate than maltose [2], and mannose and frucose, which are poorer substrates than maltose [2]. Isopropyl-beta-thio-galactose, which is a good substrate for EC 2.3.1.118 is a poor substrate for this enzyme [3].",384,1.0,-0.0031948294,-0.06615349,-0.064415865,0.03237083,0.07644148,0.014307358,-0.05288801,0.023826158,0.05877903,-0.056591507,0.031271446,0.0033248847,-0.12204932,-0.037328243,-0.038025435,-0.007431694,-0.0062674363,0.013338632,0.02837782,-0.02201116,0.15334724,-0.06756437,0.03404992,-0.0075150593,0.08160935,-0.04433541,0.00618543,-0.00040812866,-0.02567496,-0.13376084,-0.03344733,-0.06255759,0.06458095,-0.036904167,0.008607825,0.08807992,0.035948515,-0.07622742,0.024960376,-0.032565534,0.032069683,-0.029698933,-0.030827725,0.0009770062,-0.013679995,-0.06671474,-0.053733487,0.008383316,0.012637711,-0.018624341,-0.045493282,-0.06038376,-0.0159073,0.008932071,0.017900215,0.033556387,-0.03588235,-0.028936626,0.03291671,0.0055125942,0.057370033,0.087407604,0.013584703,0.008182367,-0.028772887,-0.06897131,0.060154896,-0.115559705,-0.017614858,0.0016053931,-0.097607516,-0.08780809,-0.026915008,0.061730005,0.08525059,-0.01870334,-0.03591026,-0.048949867,0.05661337,0.012828958,0.03208337,-0.01947741,-0.022942401,0.026968902,-0.01906925,-0.10001275,0.04432986,-0.033652388,-0.010335972,-0.0023953759,0.03668901,-0.018682415,0.010473391,-0.032442078,0.030007945,0.015142347,0.059857614,-0.012583436,0.041044477,-0.0066600884,0.029588172,0.056342345,0.0040340363,-0.015144846,-0.019147824,0.060102046,0.023816502,0.08892766,0.02417967,0.006711422,0.03417409,-0.03148549,0.00020545686,-0.015924575,-0.09223894,0.11058843,-0.07612938,-0.06996024,0.04365556,0.03412591,0.029719075,-0.0119265355,0.082618475,0.087267324,0.007827066,0.10271961,-0.05028343,1.0150039e-33,0.07442981,0.037733357,0.0010863327,-0.085559405,0.0025509202,0.008866663,-0.07087747,-0.021860799,0.0056440434,-0.02266257,-0.10551927,-0.06780397,0.01005736,0.020299431,0.03615579,-0.011326634,-0.02563069,-0.023903087,0.09257799,0.05425023,-0.034540556,0.025212653,-0.040587254,-0.020933019,0.058231484,0.003151741,-0.063719064,0.05671155,0.031492624,0.031826425,0.03801737,-0.019770842,-0.017772812,0.024952544,0.02091047,0.012827695,-0.035520226,-0.029363621,0.060389996,-0.014888357,0.08666342,0.076517396,0.08996553,-0.05459114,0.028608313,-0.03722004,-0.012397279,0.043936145,0.056675162,0.06014433,-0.016066665,-0.06105872,0.012664812,0.014147451,0.03033346,0.0066826283,-0.06529768,0.045542598,0.048258044,0.05883142,0.014241123,0.0862326,0.06483615,0.0010872711,-0.0020242603,0.044994928,-0.05214885,-0.027589487,-0.09343079,0.0051721632,-0.09009538,-0.013719521,0.06706591,0.019818647,0.016204055,-0.050176743,-0.046087295,0.018256357,0.04791784,-0.060040932,0.010862138,0.029882552,0.0051543987,-0.0464325,-0.075557575,0.014593309,-0.061579596,0.007917002,0.010483859,0.12347575,0.0065170964,0.01015625,-0.046561614,0.08715361,-0.0044564293,-2.6472994e-33,0.11921298,-0.11421132,0.12357408,-0.07802731,-0.079728335,0.06329888,0.0435239,-0.08295772,0.03308006,0.036999147,0.08908227,0.0127331065,-0.009539712,-0.102633156,0.057025004,-0.0050435117,-0.04502971,0.04879121,-0.023297016,0.037606075,0.018479632,0.110424384,-0.010526273,0.051649563,0.034004096,-0.04792549,0.01012849,0.008600709,0.049969602,-0.034642477,-0.010753354,-0.006839976,-0.0377818,-0.044958703,-0.04835501,-0.015409239,-0.05435478,0.015716244,-0.048965603,0.025052631,0.0020330027,0.08345701,-0.01714395,0.00895257,0.074570775,0.06897157,-0.0008293563,-0.004924814,0.019509168,-0.04710989,-0.01858943,-0.057995718,-0.06548067,0.04413669,-0.014809959,0.082898915,0.01573929,0.03170677,0.00027667676,-0.056371585,-0.05103398,-0.004178154,0.05139396,-0.13580726,0.08374019,0.02762101,-0.07220479,0.09188197,0.038444504,0.035841163,-0.004562827,-0.090545125,-0.0026405212,0.018865325,0.0073898365,-0.014882971,-0.08827015,-0.04895658,-0.021959541,-0.076724134,0.053643405,0.055440675,-0.052015472,-0.02713619,-0.06628906,-0.0021856604,0.054156985,0.07454471,-0.032313816,0.07267985,-0.056599736,-0.0058962973,-0.05004757,0.0011692669,0.0669032,-3.818679e-08,0.07508881,-0.017021876,0.04050649,-0.026685055,-0.04053592,-0.010581855,-0.011701154,0.05466038,0.012707027,-0.04333019,-0.09452446,0.15338832,0.03559329,-0.031434275,-0.023811622,0.012542969,-0.04486223,0.07237666,0.019706924,0.019179469,-0.06643848,-0.027708877,-0.06875721,0.0014055085,-0.02129027,-0.06832352,0.088901035,0.07861603,-0.0341636,-0.084431805,0.003838972,0.04732791,0.014686296,0.0019157655,-0.027224954,-0.0029997753,-0.08774406,-0.028097784,-0.0051583108,0.032781556,0.037359588,-0.061430108,-0.023001492,-0.0043524606,0.0069769733,0.023037829,0.036341064,0.0065500615,-0.03193779,0.027342858,-0.031108892,-0.07749479,-0.08161034,-0.05436746,0.011850007,-0.046881642,-0.04734471,-0.0469798,0.023201957,-0.017498177,0.06815411,-0.021200161,0.1218927,-0.032578863 +2.3.1.80,"S-Benzyl-L-cysteine and, in decreasing order of activity, S-butyl-L-cysteine, S-propyl-L-cysteine, O-benzyl-L-serine and S-ethyl-L-cysteine, can act as acceptors.",384,1.0,-0.03596285,-0.096088596,0.011286745,0.010847092,0.16117351,0.15535815,-0.03661403,0.01819567,0.09011649,-0.022108322,0.09607364,0.077427275,0.03563407,0.09558511,-0.05468717,0.04465496,-0.03415227,0.049410712,-0.04111695,0.039513912,-0.044755153,-0.032881737,-0.08421828,0.056352355,0.014517645,-0.04482477,-0.015922312,-0.001029374,-0.06730916,-0.05031963,-0.058311626,-0.033242647,0.041864753,0.025420863,0.012535916,-0.022510085,-0.051562436,0.011678723,-0.012459673,0.027404645,-0.038166452,-0.103194766,-0.010294631,-0.035510633,-0.027284753,-0.0091116,0.02422827,-0.001166548,-0.01913279,-0.017753027,0.015649825,0.0002629733,-0.05394645,0.08397125,-0.10666745,0.018535554,-0.11779743,0.0074742013,-0.02916485,0.016246445,0.021028485,-0.05018001,-0.060611274,-0.0060542086,0.050637893,-0.036940686,0.045267243,-0.04730297,-0.01719289,0.018561654,0.03182939,-0.062134303,-0.05875213,0.019954251,0.0076891338,0.040349074,-0.055390194,-0.0035927072,0.04995674,-0.052142005,0.016200306,-0.02250715,-0.04570195,0.075214304,0.06652135,-0.022774504,-0.0761329,0.07278857,0.03085742,0.050208103,0.004174316,-0.03197066,-0.06341336,-0.001538764,-0.054319095,-0.037759367,0.09932145,0.022990033,0.030733721,-0.016787147,-0.017434822,0.042154413,-0.04886134,-0.104652345,-0.02712734,-0.043754064,-0.03771299,-0.013609896,-0.048602685,-0.048716802,0.013883354,-0.056732837,0.076741785,-0.004040001,-0.063912444,0.014880191,0.10350558,-0.029843783,-0.068393596,-0.003173938,0.02212803,0.02228298,0.016707635,0.050472204,-0.03892341,0.05342942,-0.04728012,-2.0625534e-33,0.044956554,0.0022796593,0.0066427565,0.043840993,0.0144342,0.02099183,-0.04615238,0.06283501,-0.028139748,-0.047961175,-0.08074785,0.0055870214,0.037778094,-0.016496506,-0.026270874,-0.01350694,0.062826894,-0.03528617,0.050628904,-0.074291304,0.030871052,0.0454304,-0.052041553,0.029947652,0.011766006,-0.00808107,0.030893033,-0.00032096353,-0.030741561,0.0073581263,-0.0053656637,-0.040628493,-0.05529148,0.0026959095,0.046430726,0.055870388,-0.0019818288,0.0016474789,0.043786325,-0.06777222,-0.0024224368,0.044054683,-0.07629401,-0.023722269,0.008930704,-0.014353775,-0.07090105,0.058467407,-0.051061742,-0.0054277773,0.058629923,-0.06287426,-0.022268362,-0.00253871,-0.052765235,0.005365563,-0.025980353,0.043364756,-0.05224658,0.06591847,0.0020658283,0.05671356,-0.069827765,0.008155276,0.03415061,-0.0015654732,-0.08094906,-0.05262489,-0.09396906,0.04449424,-0.015934562,0.009536954,0.11481197,0.030630004,0.023703532,-0.024847902,-0.08450731,0.05146807,0.10535379,0.050601725,-0.06320795,-0.05190672,-0.035097044,0.065544784,-0.07482024,-0.024814425,0.011103286,-0.052869584,-0.010018283,-0.0035261647,-0.008796434,-0.06356458,0.069062576,0.041043006,0.06655286,-9.994902e-34,0.049234986,-0.09191316,0.06440056,-0.022544002,0.054537416,0.11170729,-0.036929812,-0.07882855,0.06778482,-0.00879375,0.0890204,-0.026442224,-0.035490602,0.01076136,0.00438446,-0.017540941,0.013850073,0.09082235,-0.045659967,-0.01073203,-0.11755993,0.031826053,0.042848516,0.061525535,0.06561046,0.028266886,-0.005065771,0.07501967,0.005020543,0.13652459,0.01416152,-0.005641926,-0.026961913,-0.05947128,0.041444827,0.11958698,-0.05191478,0.063746445,-0.0073665436,0.06890041,-0.021058127,-0.031135945,0.042294487,0.10654524,0.095238775,-0.017658347,-0.04803951,-0.00010243738,-0.017873416,-0.06676587,0.018708894,-0.03159125,-0.051356938,-0.011937108,0.06367128,0.1261373,0.05402395,-0.10301064,-0.01852807,-0.050935756,-0.008396924,-0.010545987,-0.06332007,-0.03203202,-0.04902332,-0.031582274,-0.06164628,-0.014457257,0.0759373,-0.07370233,0.08535755,-0.025971169,0.0649749,0.08947495,-0.020479934,-0.05579386,-0.029887524,0.04305946,0.003568897,-0.02829753,-0.062631354,0.0013915346,0.015461531,-0.011869165,-0.024094252,-0.060903568,-0.014502876,0.009032428,0.02676522,-0.009865933,-0.0066206385,0.052525092,0.044075366,0.07162482,0.04770433,-3.5856534e-08,0.07749374,-0.10969822,0.0071440735,-0.08079088,-0.03759663,0.026053607,0.06335411,0.04075265,0.057530407,-0.03513597,0.04574761,0.072471835,0.032135222,-0.015927596,0.08708087,-0.03387255,0.0068950034,0.03521694,-0.04377868,0.019277299,-0.046373088,-0.022937655,-0.011431284,-0.0675612,-0.034626286,-0.031653717,0.0012452003,-0.010733884,-0.061249524,0.027978549,0.07603821,-0.02855275,-0.00536911,0.0573083,-0.019650115,0.03514104,0.006390969,-0.045529157,-0.012770275,0.035133306,-0.018736396,-0.048635144,-0.13518625,0.047768995,0.05009044,-0.061582204,0.01111451,0.020520063,-0.03103415,0.036669437,-0.00852927,-0.013909557,-0.020328399,-0.016619295,0.0064527406,0.036649387,0.053693328,-0.056346856,0.009175216,-0.13155068,-0.014615415,0.039897386,0.10693585,0.02700942 +2.3.1.81,"Different from EC 2.3.1.60 gentamicin 3-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin.",384,0.99999994,-0.04130657,-0.06829583,-0.07180186,-0.042186543,0.021497961,-0.05704754,-0.04649303,0.05237433,0.07787703,-0.08788264,0.069425605,-0.036929686,0.061371617,0.02171774,0.014529906,0.0021972414,-0.019573916,0.008304197,0.057608936,0.015905729,-0.023506165,0.09188361,0.06207393,-8.992856e-05,-0.0077739977,0.06876145,0.0005321945,0.08856965,-0.0457939,-0.08893134,0.06513907,-0.0015379102,0.0058490285,-0.023584988,0.05340149,0.026939077,-0.114744544,0.032169607,0.106480524,0.041607328,-0.018080844,0.02797027,0.038461544,-0.00957314,0.051056966,-0.042990368,-0.04113784,-0.004837629,0.005895722,0.014874721,0.040644415,-0.010362441,0.047374062,0.115643114,0.056660403,0.008540358,-0.07996843,-0.047462646,-0.028892433,0.007867567,0.03511427,-0.007980511,0.019335775,-0.097415626,-0.05773472,0.009050893,0.07091365,-0.13567556,0.03710625,-0.017707122,-0.08827341,-0.025712185,0.017441856,0.056382064,0.031250454,-0.010656998,-0.01252365,0.001800085,-0.012119164,-0.05640016,-0.032923046,-0.07083617,-0.014242548,0.055469465,0.0013742885,-0.029327104,0.03038592,0.018210387,0.0224319,0.08910689,-0.00768607,-0.0007835831,0.09161357,-0.0213639,-0.06309634,-0.041062802,0.036020745,0.081543036,0.017736003,-0.010155739,-0.02015172,0.025504325,-0.109750815,-0.06609511,0.009875428,0.004059993,0.07918196,0.0037295502,-0.0015875442,-0.055775028,-0.021468123,-0.08295709,0.011041177,-0.03344676,-0.07025235,0.072023556,0.027737962,-0.06170771,0.048070867,0.00083848066,0.0110485,-0.029040946,0.025069742,0.0056524244,-0.048215427,0.10066948,-0.051265314,4.086337e-33,-0.04168071,0.057454545,-0.008606465,0.043732896,0.04554864,0.013271676,-0.06548507,-0.05236375,0.03544781,-0.16336985,-0.14606921,0.01576542,0.025099626,0.05617855,0.028338533,-0.07180286,-0.034634627,0.012915954,-0.009715106,0.008551203,0.05916046,0.04199844,-0.025746275,0.034108434,0.007590614,0.029808864,-0.0020901628,0.056662563,0.14056504,-0.009179067,-0.022648716,-0.037248705,0.048342478,0.0013278273,-0.011564496,0.0644997,-0.007638484,0.022339057,0.046372637,0.037311897,-0.037112,0.0616871,-0.021709131,-0.018057028,0.0650093,0.022892805,0.0055259448,0.08408573,-0.037295986,0.013878172,0.05289454,-0.04742614,0.017898563,-0.06906203,0.039312057,-0.0064076153,-0.0366777,0.06754261,0.036335543,0.024772016,-0.005517334,0.011963808,0.034151737,-0.03198192,-0.0055430876,0.051293466,-0.043812025,-0.02958343,-0.05400181,-0.00466805,-0.059490774,0.025253091,0.012587028,0.13079114,0.05670366,-0.010631865,-0.07782877,0.012975621,0.06138953,-0.028641967,-0.12470637,0.04227586,-0.014519027,-0.0014521058,-0.0046113366,-0.014003878,-0.009869576,-0.0067880205,0.06274604,0.05892765,-0.0044590402,-0.047883283,-0.02977742,0.035768393,0.03358022,-4.403899e-33,0.021906603,0.020424064,0.0138048455,0.027658653,0.0026640578,0.14588057,-0.031717386,-0.007897942,0.0990135,-0.008846955,0.07376662,0.00076935533,-0.0064170565,-0.07739787,0.04148266,-0.11565456,-0.0047002113,0.03707025,-0.036649402,0.024345294,0.04259745,0.017022576,-0.10524576,0.04200286,-0.04609045,0.071654394,-0.042951934,0.069899715,0.0575508,0.02687149,-0.08932094,-0.025079994,-0.009238157,0.0062293983,0.02204711,0.08457549,-0.0039962395,0.01599216,-0.05656707,-0.015267941,-0.038280968,-0.019195547,-0.02487921,0.13796386,-0.022058472,0.06354387,0.009438513,0.015528837,-0.038415316,-0.044591554,-0.01078661,-0.017012801,0.008197472,-0.024535472,0.018701307,-0.0054287273,0.0348024,0.027894272,0.06291971,-0.012881055,-0.051786914,-0.04734744,0.051786035,-0.013959131,-0.022992108,0.025294082,-0.05387039,0.03347167,0.038054172,-0.0072738496,0.020577932,-0.067954764,0.024390362,-0.041899346,0.039198004,-0.023983452,-0.055490274,-0.06941576,0.02570726,-0.07163347,-0.010072382,-0.0105591575,0.047332425,-0.014757026,-0.018177902,0.042151053,0.06735267,-0.029220395,-0.054564796,-0.030203395,0.010087176,0.031292297,-0.08739291,0.010445908,0.01893088,-3.890537e-08,0.11431546,-0.018273639,0.06455265,-0.008059338,0.02065472,0.01186353,-0.081160724,0.05053653,0.026031027,0.0050982875,0.02216611,0.10601335,-0.013372347,-0.068191275,-0.027028361,-0.0026661167,0.003854847,0.07678344,-0.030745098,0.0039100554,-0.12480211,0.027764352,-0.05263054,-0.0733742,0.06128425,-0.027895916,-0.01911401,-0.038964275,-0.025405923,-0.06089545,0.06637479,-0.040778764,-0.017705247,-0.04964558,-0.07023585,-0.068065844,-0.07438883,-0.023697484,0.042414404,0.016426777,0.07748973,-0.09111817,-0.117901,0.030949587,-0.061984234,0.007243954,0.005683606,-0.06712893,-0.09382633,-0.020671422,0.008049805,-0.06710505,0.051315937,-0.06537351,-0.09431463,0.036886893,-0.044152386,-0.04932871,-0.0091010565,-0.0597908,-0.054074235,0.020546706,0.13681458,0.074764416 +2.3.1.82,"The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2 and sisomicin are substrates. The antibiotic tobramycin, but not paromomycin, can also act as acceptor. The 6-amino group of the purpurosamine ring is acetylated.",384,1.0,-0.012455204,-0.10589085,-0.1051765,-0.092511825,-0.017824143,0.04458353,0.0012258401,0.0007141475,0.019224426,-0.016942212,0.07222403,-0.008279201,0.077606104,0.09686834,-0.033598755,0.020495838,-0.036405865,-0.009232088,0.09219977,0.023457784,-0.04509457,0.057120435,0.03450896,-0.012958222,0.05458209,0.024554163,-0.012038668,0.024679424,-0.022114133,-0.07942293,-0.00049475516,0.026907915,0.050812975,0.032778874,0.052543193,0.06747328,-0.09676867,0.02837673,0.18868802,0.0018176468,-0.030018318,-0.008224991,0.041419618,-0.008020624,0.012325318,0.01473301,0.041181605,0.008600265,-0.014984006,0.04757355,0.009168014,-0.04022547,0.044323556,0.07734134,0.03360773,0.027814345,-0.0528857,-0.047598243,-0.028623212,-0.044827845,0.026265353,-0.04803679,-0.023370612,-0.045634437,-0.1419187,-0.0022171403,0.026035408,-0.032470573,0.037268214,0.0243569,-0.012264673,-0.028930299,0.02471684,0.026860759,0.05879363,-0.0087458175,0.0063942475,-0.054749325,-0.012821059,-0.06002756,-0.025196187,-0.031264834,0.055906247,0.13570818,0.024243988,-0.026672374,0.06607104,0.081303805,0.012745708,0.04949903,0.06661125,0.027471345,0.0510598,-0.07911738,-0.080762625,-0.06978838,0.023386534,-0.007890621,0.04426373,-0.020204693,0.0052443445,-0.054151565,-0.06952093,-0.07469993,-0.018510332,0.007665673,0.018321106,-0.010997061,0.0134936245,-0.06726354,-0.048861876,-0.026904838,-0.008999579,-0.029777627,-0.057596177,0.026580606,0.13846564,-0.055911295,-0.029587122,-0.0011121563,-0.04468486,0.048342373,0.045280848,0.07805494,-0.06236571,0.03232034,-0.040860843,4.455902e-33,-0.038153417,0.04049131,-0.031299576,-0.05476587,0.030944673,-0.010340531,-0.013030413,-0.07445489,0.032762393,-0.10864147,-0.13534178,0.0054114945,-0.026811251,0.10159726,0.022001818,-0.020763058,-0.023116782,0.035190478,-0.029025456,-0.020282008,0.014425361,0.09277941,-0.05057233,0.012449629,0.024167834,0.024916222,-0.009973262,0.04512275,0.11258776,-0.016955405,-0.011162132,0.0014755399,0.05319953,-0.008563141,0.015599878,0.0006140696,-0.014413111,0.06340776,0.042156205,0.025570195,-0.025617193,0.009083742,-0.11064972,0.002796262,0.06395257,-0.034425773,-0.0072364607,0.023761297,-0.009920048,-0.04792642,0.048996523,-0.071604215,-0.0062321047,-0.10773376,-0.02638561,0.038296286,-0.00072857505,0.088191696,0.029322337,0.036586683,0.016342698,-0.050383016,0.018279202,-0.033987578,-0.00045956313,0.01501631,-0.016214676,-0.08814741,-0.04972298,-0.05706257,-0.047709197,-0.004883862,0.0018865512,0.1040062,0.03181598,-0.008122857,-0.08621198,0.010737152,0.02882657,-0.012368433,-0.08692193,-0.0016757051,-0.047847383,-0.020318253,-0.042902555,0.014815813,0.03481908,-0.05623011,0.026254123,0.020998728,-0.052565493,-0.05653098,-0.029207664,0.011953251,0.044410788,-5.7153046e-33,0.053713687,-0.04505716,0.045090962,0.02959638,-0.034932192,0.14625216,0.030787604,-0.046778116,0.103568934,0.03424452,0.050575864,-0.010272408,-0.08176587,-0.028627621,-0.02350189,-0.044248953,0.040077783,0.08198318,-0.060440313,-0.023187758,-0.039975557,0.04556377,-0.029483356,0.057609048,-0.029114123,0.11179083,-0.06564745,0.06905416,0.0830408,0.084413245,-0.02802104,-0.049011853,0.02804714,-0.07759784,0.003719042,0.0849908,-0.04806608,0.016309714,-0.09567314,-0.006794281,0.02867197,-0.016932454,-0.043420672,0.12192216,-0.022200469,-0.034048673,-0.050926615,0.021004818,-0.02665609,-0.087771714,-0.015572236,0.023233443,0.07738099,-0.057492234,0.04728323,0.024805821,0.035859574,-0.018102508,0.059666682,-0.035836454,-0.054818854,-0.05461891,0.020842584,0.0049959114,0.03437171,0.054282382,-0.052003734,0.002394224,0.04240722,-0.077921696,0.016657855,0.031719077,0.016900053,0.0553038,0.050019752,0.014167106,-0.047913514,-0.0603623,0.047053427,-0.03637053,-0.009882764,0.01722035,-0.020572381,0.028431917,-0.0038560275,0.00021501962,0.087532975,-0.041612674,0.004223149,-0.0034218421,0.06896192,0.042133175,-0.024786986,0.03389777,0.032784004,-3.963402e-08,0.1480219,-0.0603144,0.038128085,-0.06908771,-0.074599996,-0.01795559,-0.025330393,-0.036083397,0.01800086,-0.056102447,-0.005909393,0.1030847,0.014738788,-0.015418948,-0.029830381,0.017310094,-0.030369924,0.018961385,-0.04959608,-0.012352481,-0.11704882,0.038079597,-0.05068422,-0.03724045,0.0487847,0.0054670894,-0.03731631,-0.0030752958,-0.016001053,-0.037345946,0.08445653,-0.03467678,-0.043444827,-0.025898086,-0.0013834066,0.04556303,-0.026025694,-0.05567004,0.03947789,0.039288342,0.07555586,-0.06995507,-0.08031077,0.014486682,-0.04628879,0.014464517,-0.021367436,-0.027092282,-0.053855073,0.004491231,0.010344546,-0.020104198,0.005608521,-0.037200063,-0.13329439,-0.0002898752,-0.029295174,-0.058220655,-0.004812275,-0.080334745,-0.06347929,0.0010645704,0.14287366,0.013140995 +2.3.1.84,"Acts on a range of short-chain aliphatic alcohols, including methanol and ethanol",384,0.99999994,0.018010933,-0.069126725,-0.021129379,0.027521081,0.050693836,0.08203757,-0.04145807,0.016555335,0.049155973,-0.06705759,0.007085813,-0.014899392,-0.063750714,0.029978313,0.04283454,0.029343158,-0.043820977,-0.010686511,0.022910595,0.026944993,0.056713235,0.0016089502,0.0066577755,0.022425307,-0.042334426,0.0178018,0.0066161617,0.06831114,0.04487159,-0.07676426,0.076033786,0.02444805,0.05791891,-0.04644919,0.02956177,-0.0132955145,0.011504599,-0.0057990495,0.06314717,-0.026299741,0.0887689,0.02077959,0.05799449,0.056850363,-0.0410871,-0.013992755,-0.0053547234,0.0040733228,-0.03297191,-0.0947835,0.0030596124,-0.016438702,-0.0315574,0.06787056,0.08432374,0.00024143714,-0.102610454,0.026819283,0.011397075,0.053512573,-0.0070132185,0.081233405,-0.038766205,0.014965115,-0.043839797,-0.023902917,0.018865105,-0.013659766,0.06508485,0.071087666,-0.077583425,-0.081546664,0.005534878,-0.023590293,-0.010736716,-0.10031971,-0.02139183,-0.09329613,-0.045423027,-0.04330481,-0.10160564,-0.008505125,0.01788066,-0.015261576,0.027945377,-0.038499784,-0.06720553,-0.08615468,-0.021677556,0.022925958,-0.04991051,-0.04738986,0.0030676082,-0.11950421,0.06752409,-0.018284732,0.09744062,0.0021747616,0.0037309406,0.013546113,0.02175349,0.12025467,-0.086469054,-0.10992862,-0.037568815,0.017891092,0.06545109,0.0016843172,-0.05214028,0.08645168,0.03813565,-0.056384552,0.08003643,-0.057278205,-0.052287858,0.00869407,0.0003546131,-0.03157096,-0.03796972,-0.069399066,-0.027075486,-0.015035489,0.05755523,0.041526232,-0.031846654,0.031411316,0.012335847,-3.2950925e-33,0.029906617,-0.08166335,-0.054253332,-0.019074794,0.019296883,-0.1164779,-0.03987399,-0.020927798,-0.064344235,0.052603953,0.027888266,0.019670155,-0.0040011927,0.049583334,0.007889165,-0.037919763,0.010961028,-0.0033192034,0.02517847,-0.012776952,-0.12401199,-0.044692073,-0.0833275,0.058992095,-0.023140742,-0.03327616,0.01699244,0.034924746,0.01901647,-0.02126494,-0.023360612,0.13163236,-0.06618158,0.077861756,-0.0058174306,0.142041,-0.11081126,0.03089326,0.0038393221,-0.0056135696,0.027565427,0.056883004,0.0546487,-0.03190871,-0.004333701,0.07489126,-0.08470154,0.08586149,0.042490475,0.024216132,0.016499026,-0.045198023,0.008116989,0.03461877,-0.052998263,0.07071615,-0.03962211,0.001802944,-0.013782858,0.05152874,-0.073220834,0.031355374,-0.0890763,0.0043298416,-0.010548893,0.07499193,-0.11336388,-0.05135696,0.029689278,0.011505464,-0.022179315,0.05665603,0.034373783,0.038686678,0.037540797,0.057308923,-0.009182539,-0.037344202,0.07254666,0.08178046,0.035588816,-0.040390097,0.02854025,-0.04333468,-0.05377246,-0.039645437,-0.0629144,-0.004016627,-0.004663166,0.060650002,-0.043780055,-0.08411045,0.05297689,0.057475127,0.059509505,-7.912089e-34,0.06839149,-0.034151807,0.0690417,-0.051248487,0.002107605,0.027085928,0.017484909,0.0029508474,0.0057790107,0.0010772476,0.110306345,0.015302347,-0.044924103,-0.0059050685,-0.021541366,0.003911691,-0.013596723,0.069393694,0.0476257,-0.02408582,0.026638357,0.097173564,-0.037043154,-0.0056883767,0.044538144,-0.025823183,0.018993657,-0.019373044,-0.01495648,0.009521128,0.026211824,-0.055928,-0.035513837,-0.038044896,-0.06871796,0.01646265,-0.05419773,0.031465165,-0.1277054,-0.007400784,0.065613165,0.003443436,0.04652157,-0.0037591425,0.077526286,0.053410213,-0.08065138,-0.062908724,-0.04898135,-0.06482687,0.009161476,-0.016935406,-0.049508624,-0.0026250104,0.028632538,0.07357169,0.014136632,-0.010382946,0.04496582,-0.09427728,-0.07716352,0.035722718,0.048553925,-0.05521832,0.020063234,-0.071603745,-0.01819695,0.010015915,0.028803745,-0.044411086,0.071866676,0.039126657,0.08133981,0.028904187,-0.038512196,-0.13846992,-0.06992659,-0.08090284,0.003961328,-0.021858932,0.04898002,0.047955085,-0.04472778,0.011220288,-0.017610347,-0.03908288,0.03231994,0.0041637695,0.012467378,0.07876061,0.009822673,0.08988513,0.035493344,-0.029352318,-0.034401886,-2.3354174e-08,0.024023158,0.0018992188,-0.001863248,0.058875497,-0.07096888,0.0839905,0.060303837,8.503968e-05,-0.024740297,-0.029340506,-0.008371676,0.073644795,0.058898352,0.03552463,-0.002318219,-0.033216536,-0.06335133,-0.05060583,-0.004324119,-0.015505035,-0.050929822,-0.001803961,-0.001674851,0.055025507,-0.09326962,-0.053847924,0.030640341,0.03959846,-0.014286635,-0.01720518,-0.045719273,0.124663554,-0.017017776,0.018720556,-0.0044900947,-0.061502576,-0.04498618,-0.025223985,-0.09594037,0.028658383,0.019240053,-0.10322475,-0.03341306,0.0067705563,0.046823725,-0.009123977,-0.059327975,0.05257837,0.027248444,0.058442205,0.086261354,0.036054052,0.071579255,0.0339581,-0.043888252,-0.013038327,-0.021318998,-0.019708414,-0.045106135,-0.07426483,0.089315265,-0.029808978,0.09799138,0.024130229 +2.3.1.85,"The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase system.",384,0.99999994,-0.068992004,-0.04997161,-0.04693024,0.044073034,0.040290795,0.067274995,-0.07392806,0.008385207,0.062173583,-0.05125353,0.04283149,-0.08481087,-0.044544708,0.006147126,-0.018375993,0.031027788,-0.046655964,0.034588244,-0.0050718696,-0.0988914,0.06465017,0.00731234,-0.024925213,0.018944642,0.036633063,-0.05576213,0.027053965,-0.026788052,-0.1242858,-0.13232414,-0.028585132,-0.12411704,0.00084112043,-0.02144309,0.044378858,0.056450523,-0.05957641,-0.08255758,0.07870832,5.980994e-05,0.051567715,-0.05609168,-0.046630688,-0.020625638,-0.0027200994,-0.0536788,-0.103634425,0.03195646,0.04784236,-0.02345496,-0.023737911,-0.022128908,-0.04520642,0.02986216,-0.009814751,-0.021526346,-0.016809791,-0.025947057,-0.04090108,-0.010831932,0.016483756,0.0047257077,0.009497322,0.005124893,-0.008797219,-0.038287006,0.029700754,-0.061148707,0.0035459385,-0.049476653,-0.079144485,-0.1229259,0.048047673,0.03512357,0.019009845,-0.01858186,-0.00520223,0.032768067,0.07326193,-0.015934337,0.025597971,0.011506383,-0.004061547,-0.003981219,0.09687639,-0.036002714,-0.029514257,-0.013007534,-0.02467873,0.024005583,0.038292047,-0.046220966,-0.02556311,0.014689725,0.0023767848,0.04650513,0.036992356,0.02101651,0.043683846,-0.047264416,-0.02506851,0.07589233,0.033062756,-0.10381791,-0.029303975,0.013878687,-0.031248944,0.14045866,0.0018987729,-0.030432584,-0.051559642,-0.038669556,0.05406622,0.02088674,0.035499647,0.13497019,-0.080630444,-0.054260846,-0.0059035155,0.0001830015,0.02357338,-0.0116072735,0.081653796,0.059664693,-0.0031147003,-0.017998066,-0.13378273,4.698449e-34,0.04531188,0.019756667,-0.059051603,0.038906835,0.010073774,-0.014314975,-0.0787143,0.10565493,0.0012343524,-0.018034004,-0.013337108,-0.06202218,0.049019553,-0.008724941,0.04813564,-0.048218776,0.03694086,-0.02103379,0.0893932,-0.0013684917,0.0040238365,0.03343088,-0.0080169765,-0.011328816,0.012759589,0.028050873,-0.08242125,0.018553192,-0.013360175,0.032626748,-0.05923167,-0.113486715,-0.034525156,0.03604931,0.01384754,-0.042236917,-0.008698108,-0.07107697,-0.0065198094,0.082167156,0.061587293,-0.011899237,0.00038389425,-0.03011529,0.053966228,-0.0016267401,-0.082218595,0.108704485,0.04810245,0.068663456,0.051576484,-0.04900045,0.15245636,-0.03246127,-0.05574188,0.0733322,-0.105018735,-0.021617662,0.0066616177,0.037578925,-0.036455773,0.08855922,-0.03921515,-0.03033203,0.018170858,0.00021994869,-0.116585545,-0.007829957,-0.05994176,0.10177765,-0.016106568,0.029003955,0.10481321,-0.025224442,0.061883785,-0.024602797,-0.058531083,0.058878276,-0.0039205905,0.041831356,-0.010174317,0.07762755,0.027356256,0.003069538,0.0010004934,-0.0057018586,0.01601562,-0.009219982,0.021524563,0.04099816,0.06254253,-0.045924112,-0.050889667,-0.013014459,0.053171773,-2.0095263e-33,0.11927234,-0.07243993,0.020146133,-0.120657444,-0.041162927,0.07172016,0.038697846,-0.024401119,0.04842839,0.005107539,0.033296414,0.02803401,0.023332955,-0.094758965,0.029758465,0.017164784,-0.052829873,0.0068189884,0.022983124,-0.023848323,-0.04046269,0.023690451,0.009123069,0.04318444,0.05440484,0.032524962,-0.05565994,0.06404679,0.09428896,0.031577434,0.0023901775,-0.009814107,0.031122677,-0.012601013,-0.015442874,0.03662387,-0.09094857,-0.009481929,0.013911541,0.07720962,0.04151696,0.005392067,-0.048608273,-0.002470552,0.12537375,0.075491466,-0.023654373,-0.01925499,0.0069110407,-0.10831092,0.06372311,-0.008532593,-0.03725215,-0.0014597176,-0.0048737787,0.07585116,0.0058438564,0.007616571,0.06828935,-0.07107065,-0.04837121,-0.03544689,0.060047213,0.02392774,0.010311402,-0.0029513724,-0.03626762,-0.00037545816,0.028900268,0.020507704,0.05194008,0.02067842,-0.019624358,0.034107577,0.017675154,-0.041411616,-0.0588129,-0.0064902646,-0.01488019,-0.034977283,-0.00062733784,-0.032393213,-0.0032911305,-0.03012379,-0.050396632,-0.0017358428,-0.007423195,0.13006592,0.022814337,-0.0069145444,-0.013453735,-0.006786834,-0.043369275,0.11851543,0.07835153,-5.4727725e-08,0.040453754,-0.05205686,0.07943657,-0.03857435,0.07750519,0.08917932,0.020607708,-0.054319277,0.046529785,-0.04448054,-0.07216849,0.062401403,-0.0023457657,0.02459906,-0.010045255,0.004374466,-0.0024169944,0.037256792,0.026888654,-0.0010012807,-0.043321636,-0.01922385,-0.06827586,0.011252646,0.041657954,-0.07733347,0.04150653,0.008832809,-0.0175439,-0.034091737,-0.054049022,-0.008646758,0.058103908,-0.033603262,0.018639142,-0.011442354,-0.015359171,-0.06531552,-0.015625853,0.07787878,0.01679095,-0.005428538,-0.020816496,0.03564989,0.079346195,-0.0030169447,0.057403766,-0.01422555,0.008919748,-0.06447016,-0.034070004,0.0018597747,-0.061722677,-0.069954015,-0.09171421,0.011187967,-0.04253317,-0.08705065,0.03485831,-0.068373695,0.048986413,0.04547511,0.16536687,-0.0028485763 +2.3.1.86,"The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid-ester dehydrogenase. The enzyme system differs from the animal system (EC 2.3.1.85, fatty-acid synthase system) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.",384,1.0,-0.02717974,-0.08770767,-0.106479466,0.0275135,0.06577799,0.029397244,-0.07508939,0.037033685,0.086443834,-0.06624834,0.06493448,-0.06959371,-0.052882023,0.014793054,-0.0421518,0.00295864,-0.016479526,0.038215447,-0.021295572,-0.08996865,0.08612705,-0.008765849,-0.002049463,0.050217994,0.018617276,-0.058030237,-0.015390998,-0.00905544,-0.15045437,-0.18233554,-0.04659165,-0.070292786,0.042953826,-0.0030257234,0.05776034,0.06987288,-0.0663659,-0.055486906,0.074874274,-0.015357744,-0.0007457338,-0.04015908,-0.056486137,-0.008466985,-0.010083847,-0.0025456797,-0.07455062,0.0451787,0.081442446,-0.012538623,-0.010814831,0.0076072165,-0.020935165,0.029042203,-0.050010636,6.0923063e-05,-0.012414355,-0.0061095473,-0.020684881,0.023466222,-0.012863889,-0.021557136,0.0012491593,-0.008137038,0.0008055822,-0.045759123,0.059964538,-0.067703485,0.0030542635,-0.020291464,-0.05552923,-0.13121744,-0.010214411,0.071158536,0.05708048,-0.0069706137,0.016980246,0.027456127,0.025817337,-0.018408189,0.044501733,0.045647964,0.011644003,-0.024209546,0.08620167,-0.054546855,-0.016777216,0.040531907,0.028607387,0.04225383,0.03709154,0.013872791,-0.017313475,0.013443964,0.016570577,0.046040222,0.0662082,0.089968614,0.02894121,-0.07190242,0.016196825,0.06621087,0.016098952,-0.07700802,0.02358762,0.02432757,0.014242252,0.10974131,0.035824645,-0.017951433,-0.038303006,-0.07345832,0.035042334,-0.017773053,-0.0019090016,0.08664092,-0.019764261,0.012892118,-0.00811644,-0.018614426,0.046900444,-0.015279343,0.06407609,0.037119556,-0.021308642,0.0009666331,-0.15376309,2.7152517e-34,0.01849202,0.05832271,-0.09319674,0.0325889,0.0015816902,0.002851456,-0.05233024,0.100863,-0.051300664,-0.01758649,-0.06420447,-0.043886736,0.004342578,0.0006101372,0.04254638,-0.011108926,0.04740264,-0.059208978,0.045250148,0.0035522382,0.012993334,0.052628025,-0.065524206,-0.0016840656,0.06062537,-0.014132946,-0.03458834,0.027049432,-0.053640153,-0.0021327955,-0.029246368,-0.08448895,-0.057695284,0.037107833,0.051488873,-0.050727706,0.020248085,-0.037891455,-0.015462977,0.014396636,-0.0053234776,0.060548708,-0.0008692072,-0.02027671,0.011970255,-0.009246942,-0.053468723,0.08064046,0.054065943,0.07393765,0.022254204,-0.009891721,0.15226167,-0.040668987,0.0031155879,0.061978653,-0.06189121,0.020390153,0.019347064,0.061775245,-0.0326072,0.08295217,-0.023473866,0.012175188,-0.014682216,0.024459034,-0.10907174,-0.000726948,-0.0066833463,0.06691751,-0.07737078,0.045038745,0.07417212,0.00076491205,0.040588178,-0.046948247,-0.066152014,0.021349246,-0.0104692485,0.052720364,-0.03537816,0.03774286,0.035199244,-0.0032005836,-0.059948564,0.0034579807,0.026869837,0.025899243,-0.004952719,-0.011102672,0.06197986,-0.03545061,-0.026314508,0.034333844,0.087336786,-2.2504894e-33,0.12197408,-0.060827885,0.07533526,-0.14414841,-0.10156874,0.1295464,0.052391,-0.059341352,-0.013080475,0.009429918,0.043192618,0.008807309,0.005582595,-0.086465515,0.040482223,0.0066579166,-0.06731309,0.042964704,0.023717029,0.017018776,-0.04635459,0.11221335,-0.029895876,0.04760579,0.041647993,-0.011068252,-0.034191005,0.08709188,0.059194833,0.0027479648,0.004542847,-0.010345358,0.010238118,-0.014397185,-0.014926656,0.047970813,-0.09256141,-0.008318246,-0.014989134,0.07317524,0.04422932,0.028175326,-0.04992087,0.0013344297,0.08389072,0.09495592,-0.021622917,0.017124446,0.036473803,-0.09511167,0.043455698,-0.03794413,-0.027798707,-0.007668212,0.041309852,0.018288298,0.021536108,0.0026725682,0.0039858473,-0.071382985,-0.01347766,-0.054925214,0.048599605,0.0129158655,-0.0024864136,0.012403628,-0.06971056,-0.02770049,0.06838308,0.018755713,0.033613566,-0.031699184,-0.00403564,0.03729929,-0.011217514,-0.07763101,-0.062046617,-0.0026049642,-0.025060708,-0.0066952296,0.013477901,-0.016879868,0.0031579905,-0.030544141,-0.04828834,0.00608067,0.042793088,0.09161895,-0.037471913,0.027316276,0.021236505,-0.0029348123,-0.046584316,0.10438873,0.07602868,-5.5136297e-08,0.09523043,0.0020316406,0.07553707,-0.10857815,0.032855112,0.037473354,0.023340592,-0.043127563,0.025646467,-0.007817761,-0.102217376,0.07118062,-0.0012249522,0.025875859,0.025258841,-0.0043017617,-0.03342904,0.045830324,0.052498825,0.052775912,-0.01125274,-0.040788557,-0.12888502,0.027802918,0.015512029,-0.06199503,0.051007345,0.0064785015,0.01171999,-0.03182852,-0.042022694,-0.0413062,0.0366783,-0.033989593,-0.03938359,-0.04029882,-0.05632757,-0.07895666,0.000715055,0.056923304,0.044903714,-0.07264614,-0.02717506,0.042379517,0.03421107,-0.008403054,0.075374916,-0.013817729,0.03124354,-0.010820814,0.0066023148,-0.022902206,-0.04706076,-0.05148847,-0.060089335,0.009881099,-0.03738496,-0.06817775,0.040358093,-0.06355668,0.047489036,-0.015293816,0.15092789,-0.05935825 +2.3.1.87,"Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.",384,1.0,-0.0034625256,-0.026769646,-0.020747906,0.038789976,-0.012952653,0.028040575,-0.03631365,-0.024648055,0.051386822,-0.022149965,-0.03965923,-0.071006685,-0.06776472,0.012423372,0.053689945,0.10527181,-0.045266557,-0.032330226,0.038621455,-0.0015251533,0.11137738,-0.00878089,0.01334875,0.0052332785,0.01580423,-0.005680177,-0.062133405,-0.00018051737,-0.03000556,-0.04943773,-0.0066712303,-0.042358432,-0.07003099,0.0035914176,0.06394833,0.0014623493,-0.03385714,0.00049964327,0.018785922,0.03388467,0.046842553,-0.003396201,-0.041487433,-0.041789588,-0.0056200465,-0.06715444,0.024002083,-0.0601353,-0.011090197,-0.0018220172,-0.044608757,-0.067173734,0.0032523472,0.016720174,0.03164549,0.04843253,-0.06634007,0.015030775,0.06109159,0.022056483,0.027340973,0.06376179,-0.024180928,-0.09292476,0.0019902582,-0.015617099,-0.0046162163,-0.12751621,0.06842872,-0.006343775,-0.06887676,-0.06771631,0.05096388,0.012665168,-0.011141426,-0.049770214,-0.0302277,-0.0054195905,0.01852669,-0.06176078,0.0009506667,0.0072200056,-0.009375044,0.06520049,0.025120553,-0.009620477,0.008431948,0.10994804,0.023387607,-0.0027584066,0.018794741,-0.041988924,-0.0107070925,-0.01559494,0.0027331784,0.015505832,-0.016249903,0.04839573,0.018194897,0.041657872,0.032305732,0.027476225,-0.08891781,-0.04135969,-0.017118562,0.0065666377,0.03781819,0.0008687526,0.016652988,-0.09824244,-0.027349273,-0.021320084,0.010636779,0.089687474,0.020563351,0.09526565,-0.05009973,0.009396222,0.0731872,0.05207398,0.06672699,0.014294483,0.12943839,0.059821684,-0.010913256,0.07743532,-0.0826796,5.0046878e-33,0.06707334,0.03580091,0.07790865,0.0408608,0.016631905,0.043154426,-0.098242916,0.012229977,0.09263123,-0.109436415,-0.053984392,-0.04712336,0.02168737,0.051856946,0.03535204,-0.051581867,-0.06510703,-0.026428727,0.08357887,-0.024373433,-0.07817134,0.024907047,-0.016045181,0.013910109,-0.065101616,0.01622301,-0.0643126,0.044272486,0.032876614,0.01068204,0.0064094616,-0.029196415,0.021093475,0.0718545,0.011938305,0.0781358,-0.010200753,0.01640698,0.0007084395,0.044954322,-0.026217362,0.06632362,-0.00016902623,-0.018696222,0.0071075894,-0.0073562153,-0.075630054,0.04537949,0.043725517,0.019132785,-0.0054860543,-0.042116687,0.0364683,-0.06620514,-0.027059078,-0.021376776,-0.02122926,-0.026154809,0.028875843,0.059076216,-0.028341103,-0.045130584,0.031673536,-0.07228188,-0.042066567,0.036355108,0.038445678,0.0016168595,-0.045363728,-0.0028641056,-0.013834586,0.015653094,0.105451465,0.048623916,0.065672316,0.004894601,0.028696219,0.049685385,-0.009714755,-0.046689633,0.041588135,-0.012565965,0.019877704,-0.008018239,-0.049119633,-0.03229282,0.0063299225,-0.032534927,0.055272654,0.11693802,-0.023168487,-0.08882367,-0.021588903,0.025716214,-0.008929141,-4.3074246e-33,0.030456003,-0.07685698,-0.010726243,-0.07819837,-0.040142115,0.08848996,0.015137883,-0.064430654,0.020722875,0.040815324,0.12304604,-0.010724656,0.08720488,-0.04874087,0.04221994,-0.07181928,0.006363214,0.055380844,0.07932753,0.013198328,0.0021928505,0.019798923,-0.10957866,0.038989365,0.13706547,0.014839614,-0.04765925,0.035479303,0.07013831,-0.017194165,-0.04777254,-0.016783873,-0.04343529,-0.027138688,0.042409502,0.048841503,0.006652469,0.028653305,-0.07523507,0.0073035196,-0.0046550496,0.043515522,0.046819076,0.004421344,0.011847528,0.1299663,-0.019065775,-0.017007949,-0.072178796,-0.05187184,0.01965081,-0.09794998,-0.061611604,-0.047171555,-0.04369105,0.028902465,0.0010037466,0.007036901,0.0036164387,0.0009070003,-0.0724516,-0.030750807,0.014357389,-0.07832324,0.0055564106,-0.012919088,-0.010086298,0.10742739,-0.016074134,0.012214624,0.08141302,-0.054050293,0.091156006,0.08516019,-0.080028914,-0.08944815,-0.0034222456,-0.08744985,0.00012521383,-0.13973057,0.054276455,-0.026998872,-0.005527525,-0.061401334,-0.07027528,0.011752485,0.12264038,0.089080215,-0.005087461,0.020923458,-0.04336665,0.03044917,-0.09321756,0.03050451,0.015544277,-4.5151403e-08,0.06283746,-0.11037831,0.038671616,0.0067177466,-0.017405676,0.012911373,0.0428518,0.06717868,0.0270723,-0.045204654,-0.0060496572,0.027197585,0.07251158,-0.027479213,-0.13364527,0.0050736046,-0.007821961,0.079098724,0.04353963,-0.021120636,-0.09260788,0.015232419,-0.04299212,-0.041792076,0.020765558,-0.054538276,0.04633524,0.101260826,0.02718549,-0.13013452,0.04234036,0.0092013385,0.073780105,-0.04531205,-0.09392865,-0.0065401806,-0.00080186594,-0.035382587,0.003985172,0.0024065138,-0.001860787,-0.042590044,-0.05264883,0.0020198757,0.07277705,-0.036615267,0.028601643,-0.07695424,-0.017190246,-0.021915335,0.030373065,-0.0030316352,0.048010472,-0.05211164,-0.09433132,-0.037316937,-0.052834038,-0.011136367,-0.0054197186,-0.078434296,0.020213632,0.071476005,0.148587,0.034978077 +2.3.1.88,"Acetylates N-terminal alanine, serine, methionine and glutamate residues in a number of peptides and proteins, including beta-endorphin, corticotropins and melanotropin. cf. EC 2.3.1.108 alpha-tubulin N-acetyltransferase.",384,1.0,0.03514295,-0.07650044,-0.0850229,-0.033178836,0.039971836,0.1256384,0.013869583,0.012065613,0.019991638,0.016603151,0.028332803,0.005958173,-0.083105646,0.015087067,-0.03922992,-0.00054874684,-0.08236734,0.04884609,-0.01005454,-0.049471088,0.031566747,0.084626704,-0.024597986,-0.032004584,0.0028207267,0.019973516,-0.027144875,-0.028592983,0.021098716,-0.044181347,-0.027677638,-0.06127394,-0.055821046,-0.0019268286,0.065774865,-0.017855346,-0.05034761,-0.06093153,0.07843575,-0.025921188,0.09385776,0.037492298,0.0077726603,0.0075023044,0.066265605,-0.012259771,-0.013409385,-0.022022225,0.08623581,0.034081236,-0.006779703,-0.049557395,0.049354453,0.056854717,0.0061019775,0.0028813756,-0.087166935,-0.056248903,0.07674299,0.09290745,-0.002914785,0.028382657,0.015438748,-0.112533435,0.06474453,-0.008014514,-0.01952403,-0.098467134,0.0470291,-0.0428853,-0.03252463,-0.07601401,-0.05625356,-0.018799027,0.0110395,-0.018176533,-0.08857429,0.034279168,-0.021675682,0.0012909628,0.10507706,0.040005226,-0.0047812173,0.06492384,0.008005626,-0.012995651,-0.038189504,0.051993027,0.018242285,0.02372609,-0.046314094,-0.12314809,0.059475623,-0.056662843,-0.050302595,-0.08478926,0.01963168,0.012647223,-0.020473493,0.054849885,-0.031742193,0.057790626,-0.014293869,-0.021461515,-0.07751713,0.036591947,0.0623312,0.059702806,-0.0049550356,-0.03446702,0.0038066455,-0.04228274,0.019358147,-0.01407103,0.02142344,0.004392666,-0.041370127,-0.016782321,0.033990845,-0.008658845,0.05455328,0.022793762,0.08547998,0.0836728,-0.018966885,0.06984885,-0.079309665,2.8306685e-33,0.06659431,0.013275665,0.10113115,0.03305816,0.058131576,-0.044738185,-0.052759618,-0.040006734,0.17418255,-0.06123959,-0.095283896,-0.03131844,-0.000467501,0.016630474,-0.0035241472,-0.017621478,-0.01282812,-0.022561317,0.12635243,-0.019660166,-0.02619989,0.02938125,-0.014116493,-0.006118611,0.031221088,-0.07289902,-0.05977565,0.078522824,0.058907684,0.01804937,-0.027830658,0.01713824,-0.017763425,0.04382151,0.045064736,-0.024590205,0.034749445,-0.056105178,0.05886905,0.009371142,0.0048377262,0.041642364,-0.04443606,0.028193144,-0.016079979,-0.045784704,-0.026943624,0.016628597,-0.01894119,0.03206062,0.0029190113,-0.040583886,0.052280508,0.002456225,-0.04330004,-0.01712749,-0.08404631,-0.027166938,0.0020264308,0.10905444,-0.038093742,-0.025632206,0.0061405236,-0.038900964,0.0045145373,0.052382663,-0.054800026,-0.06444043,0.03658544,-0.0020644728,-0.06441845,-0.020119848,0.069819756,0.045030735,-0.0005645109,-0.035085376,-0.083318196,0.068533435,-0.02677388,-0.017570931,0.017941698,0.07519258,-0.05186784,0.036392532,0.009108103,0.021368561,0.0750309,-0.06407339,0.032549456,-0.046775732,0.023991473,0.03428623,-0.0070907585,0.06517343,0.001565943,-3.0019929e-33,0.0508436,-0.10440825,-0.017402703,-0.031154191,-0.12014451,0.05895436,0.030483548,-0.04305456,-0.013701412,0.013131551,0.0563399,-0.023259321,0.039383095,-0.08240122,0.06412915,-0.06593913,-0.014724107,0.06459103,0.06588061,-0.027911969,0.00021063993,-0.0076995194,-0.016413718,0.029607423,0.053607915,-0.010527222,-0.03266545,0.06738712,0.062389165,0.0633018,-0.017520955,0.017561214,-0.0093676215,-0.06322221,-0.061724503,0.04742121,0.026789054,0.021722421,-0.053600222,0.024245769,0.052860428,0.048045788,0.020563288,0.06299667,0.054257732,0.040811144,-0.009436333,0.009837334,-0.036596462,-0.049412895,0.038297813,-0.09201179,-0.04058249,-0.09231927,-0.003089484,0.05363991,0.043483343,0.044130012,0.032525044,-0.019282734,-0.02838877,-0.012801201,-0.05289685,-0.047238555,0.08977143,-0.022213364,0.044229742,0.004733425,0.057701442,0.01583974,-0.004851853,-0.025025439,0.17131223,0.09350641,0.07802214,-0.05254566,-0.077045515,-0.059404418,0.02745709,-0.09137673,-0.07097153,0.014159045,-0.036924176,-0.029605413,-0.01244697,0.023620268,0.031668406,0.0996881,-0.014414202,0.078206204,-0.028864535,-0.02162247,-0.09266556,0.06108535,-0.024172492,-3.6133734e-08,0.13468306,0.017968671,0.004027944,-0.043587405,-0.03330127,0.037937295,0.04799611,0.040173505,0.016584862,-0.033526003,0.007225925,0.07970777,-0.009799039,0.020708933,-0.07479204,0.08184745,0.043416448,0.0754985,-0.012579526,-0.0108673265,-0.07482381,0.024294963,-0.004713563,-0.015575759,-0.0026514842,-0.09628087,0.016800141,0.14597704,-0.057924997,-0.050776172,-0.0058552213,-0.057793926,0.013690412,-0.12097062,-0.032200385,0.024593443,0.011871996,-0.0701375,0.05664818,-0.022403127,-0.054262787,-0.031772185,-0.05650995,0.009315248,-0.008444842,0.013308487,0.024062831,0.063040696,-0.07694068,-0.041056946,0.023914997,-0.024828717,0.00092548813,-0.03129687,-0.09306658,-0.07946835,-0.036515627,-0.022348229,0.022686524,-0.046186164,-0.027250355,0.055690587,0.07500213,-0.0404861 +2.3.1.90,"beta-Glucogallin can act as donor and as acceptor. Digalloylglucose can also act as acceptor, with the formation of 1-O,2-O,6-O-trigalloylglucose",384,0.99999994,-0.11498432,-0.09203349,-0.054915585,0.02695683,-0.050224572,0.014755382,0.06063542,-0.029981537,0.034886003,-0.03289993,0.028479971,0.05136836,-0.11646875,0.09777729,-0.057818536,0.0155145265,-0.02316362,0.0259756,-0.08554009,0.0031087438,0.012073373,-0.031004934,-0.017537488,-0.059998322,0.07309641,-0.08238863,-0.06252688,-0.016544668,0.0556988,-0.0825522,-0.018240185,-0.004507253,-0.034005538,0.065713376,0.021036517,0.020465974,-0.07450026,-0.051265568,-0.055127405,0.028656624,0.070947334,-0.058621343,-0.011256851,0.05464268,-0.053658262,0.0029793365,-0.0583729,0.047202528,0.011647246,0.009683189,-0.022781953,-0.059667934,-0.09269984,0.05164208,0.061136458,0.020003788,-0.012398387,-0.051175974,-0.001127162,0.030088823,0.013280844,0.009971054,-0.08154118,0.02883201,-0.053494137,-0.00978631,0.04358891,-0.058954164,-0.031773098,-0.013232728,0.07569799,-0.02871329,0.025708852,-0.052456003,0.042885672,-0.0011379019,-0.05095969,0.029758496,0.040968265,0.040938817,0.024361836,0.03743698,0.033575654,0.071399294,-0.004554214,0.011597036,-0.06646871,0.08167765,-0.023216043,-0.0029847412,-0.034301646,0.00084417395,0.017418204,-0.08242634,0.087980285,-0.033013,0.08181623,-0.05171993,0.011246263,-0.033733796,-0.04323277,0.034346532,0.0012290309,-0.106935784,-0.0547347,0.04530534,-0.029267041,0.05683345,0.05532543,-0.021313243,-0.052926812,-0.026125642,0.15047628,0.049055383,-0.08096144,0.029162547,0.0060041985,-0.098995104,-0.06567741,-0.04962796,0.0024895202,-0.049304295,0.027254537,-0.020446863,-0.07886714,0.006041635,-0.050067406,2.505941e-33,0.0801639,0.02535478,0.008221409,0.005806495,-0.07661634,0.03544941,-0.070050046,-0.046012785,-0.046447244,0.009722375,-0.051833607,-0.032869756,-0.020390771,0.15869054,-0.07552318,0.050068922,0.02417563,0.039821822,0.04805821,-0.003456175,0.016637893,0.07478426,-0.07989027,-0.020324271,0.0051682373,0.06369516,-0.06613381,0.044684574,0.03754059,-0.015195234,0.1052912,-0.05253909,-0.016049782,0.06354525,0.006722367,-0.0046535283,-0.01933133,-0.02376215,-0.021690635,-0.042239226,0.019788539,-0.015399796,-0.058981743,0.046986196,0.08865355,-0.020788169,-0.036316473,-0.09065896,-0.02939265,0.10150246,0.00969701,0.0058463397,-0.009790272,-0.01631607,-0.013362626,0.0068536033,0.022077568,0.07538589,-0.0017487362,-0.013066998,-0.017629473,0.03666443,0.0018013825,-0.07677868,-0.027269548,0.00044064154,-0.057276387,-0.03979977,-0.09933696,0.0440076,0.0060946774,0.025966112,-0.0822942,0.027843809,0.03128664,-0.0778065,0.044032007,0.0067796037,0.058896102,-0.019242192,-0.011173125,-0.004242806,0.010008842,-0.016477654,-0.12779722,-0.029038956,0.052314043,-0.039503943,0.009221365,0.02824533,-0.0017395386,-0.0053548794,-0.034443114,-0.017009415,0.10433954,-2.8311877e-33,0.111538514,-0.09791831,0.025143346,-0.005678953,0.007966639,-0.0031809835,-0.009455471,-0.099819824,0.13506751,0.021948317,0.06727525,0.06404026,0.039921205,-0.0037696287,0.05414282,-0.049827144,-0.034309592,0.02120383,-0.061117057,0.02260826,-0.018497162,0.052696723,0.006115023,-0.010843209,0.05097809,0.06415525,-0.03855502,0.0019456284,0.056567173,0.04999388,0.024936851,-0.034304902,-0.023373056,-0.076389916,-0.03885685,0.044927612,0.011674925,0.059151415,-0.0450738,0.004402124,0.013799743,-0.031241039,0.028828345,0.08688116,0.06727979,0.041339178,0.03527801,-0.020769104,-0.005564518,-0.035402007,0.021639062,0.05669103,-0.010157838,0.049173035,0.116273016,0.07944101,0.118167624,-0.07486036,-0.031466845,-0.08711149,-0.014805099,-0.050462697,0.060010828,-0.0067176223,-0.01269031,0.023463354,0.03456073,0.04637342,0.007880631,0.02914795,0.009979861,0.0014885314,0.014571589,0.05382121,0.06078258,-0.08470924,-0.08574578,0.0012992888,0.01154237,-0.040034913,-0.10590049,0.06393705,-0.02523648,-0.0023947181,0.036659796,-0.083264254,0.040937625,0.04444367,-0.020770872,-0.011896883,-0.07172497,0.027128799,0.0031133213,0.048502088,0.07960919,-3.318226e-08,-0.019293914,0.06552809,0.0013232583,-0.08370826,-0.0067464532,-0.044646233,0.03854858,0.0612948,-0.0091028325,0.015841035,0.0015835633,0.12544413,0.041253738,-0.0432684,0.08436067,-0.006614338,0.01617993,-0.090664655,-0.0032832387,-0.03868891,-0.03125712,-0.012176422,-0.0010365687,0.028523846,-0.086540975,-0.067917965,0.06492615,0.059187755,-0.06447876,0.06271118,0.015838835,0.07023356,-0.05234934,-0.034978006,-0.0039969278,0.044143666,0.037586045,0.018080905,0.04106581,-0.0009585355,0.007388054,-0.0071840915,-0.05599389,0.01860018,-0.060247384,0.003018123,0.10095855,-0.051104084,-0.0016593226,0.06000221,0.05672054,-0.0534092,-0.023480838,-0.0074883383,-0.08549367,0.025581501,0.03805667,0.04038722,0.07374815,-0.0047510364,-0.022340026,-0.048410285,0.11552024,-0.01625182 +2.3.1.93,"Benzoyl-CoA and, more slowly, pentanoyl-CoA, 3-methylbutanoyl-CoA and butanoyl-CoA can act as acyl donors. Involved in the synthesis of lupanine alkaloids.",384,1.0,-0.08765095,-0.095703624,-0.025354756,0.009234764,0.028683344,0.020372933,-0.08058733,0.008867951,0.053991653,-0.039349247,0.093511485,-0.06948699,-0.100668594,0.010499304,-0.053771257,0.11121104,-0.041783698,0.073338844,-0.047308512,0.0041111065,-0.052948035,-0.009961228,0.019596541,0.0038486195,0.062279236,0.016938817,0.005332467,0.009417478,0.044790443,-0.067607865,0.010088287,0.0004007267,0.022806402,-0.0593085,-0.033506867,-0.0139393825,-0.05598099,-0.028633531,0.1015346,0.14073434,-0.049772535,-0.07381156,-0.028286487,0.035065953,-0.08048274,-0.14013019,-0.050277013,0.035446893,0.010686432,-0.014095978,0.013799305,0.025743457,-0.05089516,0.041728962,-0.083404586,-0.021982513,-0.031438723,0.078265294,0.0031500054,0.041489895,0.018482868,0.050023355,-0.045660045,-0.03525435,-0.10079729,-0.006496881,0.0120218145,0.0050336695,0.035484385,0.009719299,-0.005945272,-0.06949155,0.07466031,0.028876526,0.06753068,0.085821465,0.0073629566,-0.021741824,-0.05470838,-0.01916864,0.012653876,0.04473434,0.012613783,-0.010595353,0.036724232,0.035062987,-0.03206762,0.048887234,0.0034787392,0.028973404,0.043584462,0.042980142,-0.022522831,-0.040192798,-0.04976206,0.13745661,0.10091788,0.05097506,-0.017977748,-0.0105361715,0.06976037,-0.007141055,-0.046961628,-0.06895414,-0.060866345,0.0006750045,-0.0037392133,-0.042358913,-0.03843716,-0.052432287,0.06507296,-0.043369833,0.01890702,-0.069252074,-0.07457074,0.018532652,-0.055544756,-0.03791618,-0.0461807,0.06775847,-0.0011354005,0.004597998,-0.012692323,0.011057148,0.021458406,-0.02411012,0.001237666,1.5391857e-33,0.054432232,0.073963545,-0.063260786,0.08697476,0.026544835,-0.08346705,-0.04177929,-0.008652129,-0.13766256,-0.091904245,-0.04780845,0.035122372,-0.020395087,0.013984759,-0.0193572,0.002012371,0.027429875,-0.06371576,0.09739826,-0.020835886,0.053478185,-0.03015394,-0.024956219,0.0002677232,-0.006155485,0.032745156,-0.034799956,0.054028094,-0.017177092,0.015934194,-0.08234757,-0.03714687,0.0075419596,0.029707588,-0.04274232,0.0011925738,-0.025356583,-0.07779566,-0.01686927,0.03579293,0.08947595,0.07438397,-0.0030407836,0.1116674,0.044470444,0.037907515,-0.040598016,0.02831787,0.0039801695,0.05637338,0.026612272,-0.07562883,0.0521964,0.037076175,-0.038085137,0.015276501,-0.07951177,-0.0143156,0.029109815,0.018212201,0.00031249368,0.05045161,0.008462387,0.04624919,-0.021899734,-0.021610728,-0.06816019,0.0068062195,-0.007190502,-0.03642701,-0.014339105,-0.0654631,0.047114283,0.10848776,0.052232448,-0.008971297,0.03955648,0.020169662,0.05819844,-0.020299716,0.01710935,-0.017525848,0.021997927,0.026614422,-0.003743736,-0.017757667,-0.028006364,-0.04586922,0.03330767,0.028741328,-0.041211486,-0.038637165,-0.009487129,-0.03629612,0.050142925,-1.9015272e-33,0.1178157,-0.097300254,0.035580408,-0.069094054,-0.061400153,0.03137505,-0.019073537,-0.08857482,0.04397411,0.09229844,0.070776485,-0.021280747,0.048228648,-0.027069448,-0.0121377995,0.031480547,0.078186594,0.019391757,-0.014441266,-0.008004555,-0.09482841,0.006046681,-0.0028087627,0.026167767,-0.0291238,0.033918727,0.023355555,-0.08355443,-0.025370875,0.06768984,-0.0064145215,-0.017377844,-0.06991584,-0.032217998,0.0048903176,0.09777574,0.04111965,0.017798377,-0.06285461,0.05348962,-0.047846753,-0.038482416,0.06609989,0.029021166,0.020943252,-0.012314362,-0.014472448,-0.046981115,-0.031959724,-0.1295297,0.07056769,0.04307828,-0.04386407,0.015839774,0.03245666,0.018387157,0.07760733,-0.07308806,0.07241017,-0.07221798,-0.072971374,-0.013640942,-0.015267581,-0.018160606,0.09572023,0.08611163,-0.0040285024,0.06140019,0.04227181,-0.04880716,0.10064172,0.0054596653,0.026086843,0.06933155,-0.031870864,-0.028760554,-0.029614335,-0.06187087,-0.045894954,-0.0071666376,0.04693275,-0.11519411,0.01722644,-0.018669825,-0.07678448,-0.021980181,0.009015609,0.028656367,-0.04143639,0.022680854,0.030286895,0.047262296,0.032117788,0.1140769,0.10504972,-3.2456512e-08,-0.038072705,-0.021509955,-0.031370174,0.004044344,-0.012016981,0.01942623,-0.013601102,-0.031872354,0.05359032,0.0062713693,-0.07641803,0.046162736,0.0825491,0.09520679,0.021979513,0.014053737,0.010472539,0.035502434,0.017991235,-0.015577871,-0.07103719,0.083066784,0.038618542,-0.06362669,0.013142575,-0.049769744,0.036163617,0.032766428,0.063845046,0.003889684,0.046498764,-0.014299971,-0.039878722,0.021555958,0.03790532,-0.046491347,0.031863455,-0.083392456,-0.076388076,0.021973414,0.027017767,0.006663365,-0.096011885,0.033823393,0.043457255,-0.04766477,-0.024694627,0.049037237,0.038620498,-0.030348595,0.045504298,-0.03514411,-0.0015618668,-0.05019235,-0.04940683,-0.083121344,0.0029789994,0.050943993,0.040882066,-0.12650435,-0.062929496,0.047186773,0.111094385,0.0063193594 +2.3.1.94,"The product, 6-deoxyerythronolide B, contains a 14-membered lactone ring and is an intermediate in the biosynthesis of erythromycin antibiotics. Biosynthesis of 6-deoxyerythronolide B requires 28 active sites that are precisely arranged along three large polypeptides, denoted DEBS1, -2 and -3 [6]. The polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain [5]. Each extension module contains a minimum of a ketosynthase (KS), an acyltransferase (AT) and an acyl-carrier protein (ACP). The KS domain both accepts the growing polyketide chain from the previous module and catalyses the subsequent decarboxylative condensation between this substrate and an ACP-bound methylmalonyl extender unit, introduce by the AT domain. This combined effort gives rise to a new polyketide intermediate that has been extended by two carbon atoms [5].",384,1.0,-0.056323126,-0.0199418,-0.078456886,-0.073171265,0.016831087,-0.0024317764,-0.031002978,0.09567464,0.08363526,-0.028829953,0.0026416155,-0.023590371,-0.022948153,-0.01694914,-0.029011074,0.07890056,-0.08743983,0.080039315,-0.02365794,0.02762342,0.016246295,-0.003959563,0.017390303,0.009282534,0.062403496,-0.04505311,0.025881488,-0.018791415,-0.020497901,-0.064266786,0.054296385,-0.035407003,-0.037528243,0.009404307,0.069954865,0.1340456,-0.063519344,-0.0013444526,0.12430351,-0.05805266,0.08729222,-0.010705835,0.03745192,0.01676627,-0.0012743578,-0.003953308,-0.08517112,0.032855608,0.011210072,-0.022389665,0.01076142,0.02319518,0.0060810195,0.056110308,-0.011848591,0.0053555337,-0.055370566,0.001969238,-0.004659526,-0.010813705,0.052625597,-0.06619348,0.029912412,-0.03165896,-0.13544717,-0.027090518,0.036811247,-0.0312649,0.011945702,0.052163925,-0.11647179,-0.0025582958,-0.03396951,0.081998676,0.053841136,0.013332683,-0.0054124296,-0.00093746977,-0.046212792,-0.027187716,0.052468028,0.019611444,0.12372382,0.09274143,0.041935556,0.005477398,0.048350118,0.040609036,-0.01212057,0.060033366,0.015794795,-0.013025439,-0.0023426546,-0.02391591,-0.028849024,-0.035474405,0.016701784,0.044892047,0.027651114,0.022364073,-0.037649512,-0.010271128,-0.039178558,-0.08619032,-0.024108773,-0.04085547,-0.018059745,-0.013096151,0.05633431,-0.06734534,-0.08460896,0.00024852427,0.038349442,-0.001025768,-0.048657227,0.10917631,0.009804482,-0.054652777,0.0605354,-0.099661544,0.003510292,0.011438813,0.018040815,0.062994495,-0.03302555,-0.067065775,-0.11419705,4.4462027e-33,0.023243725,0.056317493,0.05573444,0.01141893,0.037126396,-0.012505003,-0.044531517,-0.04614825,-0.09754741,-0.025446918,-0.087612495,-0.10728843,0.03673713,0.055576738,0.046909276,-0.061453283,0.03791764,0.014958758,0.03198319,-0.022434467,-0.016266823,0.020677557,-0.081241444,0.07350525,0.026395634,0.055368755,0.037991125,0.08256957,0.0020822121,-0.02200983,-0.09473848,-0.027269334,-0.0114736,0.08863984,0.04061075,0.018771525,-0.047393885,-0.024636671,0.054253966,0.015460438,0.009288703,0.033680446,-0.045541227,-0.06926168,0.07142041,-0.0016784989,0.015414977,0.056274045,0.0195352,0.08787988,0.0005550061,-0.0027782046,0.08364356,-0.0033391286,-0.052354064,0.0044059395,-0.10668083,0.014402381,0.0701532,0.055017915,-0.0032306435,-0.062428765,0.0038864925,-0.013851111,-0.0034137182,0.07866116,-0.051915366,-0.01694969,-0.031037439,0.04916305,-0.026715504,-0.023042738,0.08536086,0.018313225,0.06361576,0.071318775,-0.10513355,0.0148874745,0.018524298,0.039218828,0.0027525348,0.028870804,-0.0074728094,-0.076525934,-0.046473328,-0.044653006,-0.05894752,0.0019750108,0.0043621496,0.049825568,-0.021827389,-0.13619304,-0.04193737,0.082067795,-0.0057150144,-5.074347e-33,0.13504423,-0.011046193,0.0099981995,-0.065290414,-0.031005012,0.044097126,0.025326818,-0.023264548,0.020612232,-0.0013829909,0.11158397,0.0040434096,-0.0043531395,7.9439174e-05,-0.029076276,0.028830003,0.01460912,0.07610237,0.018696295,-0.013914022,0.009151599,0.031996418,-0.06328004,0.031740963,0.042060565,0.06792152,-0.031786457,0.06286532,0.05056647,-0.004567836,-0.08756235,-0.06502377,-0.040149897,0.008440736,-0.022477282,0.04310443,-0.0681683,-0.00015941572,-0.004911566,0.026908752,0.03694848,-0.067522496,-0.008387303,0.06659698,0.07465109,0.061965406,-0.0838895,0.0163659,0.031543765,-0.09235418,-0.0125238495,0.01299369,0.046411525,0.01609421,-0.018311879,0.0658704,0.10867822,0.010347258,-0.005583395,-0.0807489,-0.04505735,-0.03331637,0.06321226,-0.019409679,-0.052271903,0.074232206,-0.02803765,0.055280205,0.010277855,-0.032429647,0.040465504,0.08646201,-0.03647971,-0.00553377,-0.025714355,-0.048313554,-0.031642895,-0.09529652,-0.046714053,-0.0010338768,-0.07049814,-0.05101298,-0.0188534,-0.040397912,-0.002569868,0.005978421,0.060826167,0.009375803,-0.0397205,0.021870637,0.034653563,0.071711496,-0.041442726,0.16641364,0.038910434,-5.2965e-08,0.050104238,-0.023217665,-0.05092602,-0.07348171,0.017854946,-0.007957469,-0.016800027,0.014701869,-0.0544994,-0.08792395,-0.050578173,0.057895444,0.009833698,0.02514088,0.0052534156,-0.050746776,-0.03780859,-0.018389633,0.013488887,-0.022854446,-0.06131273,-0.010712977,-0.03664533,0.008857908,0.025959248,-0.045697026,0.022920111,-0.010061034,0.007181779,-0.003904619,0.02717719,0.06611873,-0.06455762,0.022361513,0.019040013,0.025529237,-0.11403653,-0.07929288,0.013349339,0.050011862,0.03893134,-0.0004831571,-0.03243543,0.05688738,0.020520328,-0.00037335596,-0.017516539,-0.08209805,-0.055300523,-0.004331105,0.084995456,0.018547326,-0.029317243,-0.026618993,-0.08608089,0.09798967,-0.069141835,-0.03859818,-0.057093184,-0.0124489935,-0.053500507,-0.09028527,0.14878923,-0.032095492 +2.3.1.95,Not identical with EC 2.3.1.74 naringenin-chalcone synthase or EC 2.3.1.146 pinosylvin synthase.,384,1.0,-0.09882394,-0.10090222,-0.05159513,0.003122035,0.041203447,-0.08566058,-0.0463739,0.029961532,0.069887005,-0.09062012,0.010543204,-0.06683729,0.0149814645,-0.0064699594,-0.065266065,-0.074214846,-0.043595396,-0.03204592,0.03245673,-0.036022846,-0.0033872987,-0.021474343,0.04811783,0.08100536,0.057906993,-0.019208474,0.0909204,0.0219963,-0.022219976,-0.11148927,0.0346705,-0.010652983,0.0152830975,-0.02631422,0.007669358,-0.016512336,-0.04457497,-0.08418507,-0.012912543,0.03287351,0.05767141,0.018477917,0.04809557,-0.025049038,0.0361834,-0.030083999,-0.105656,-0.03675752,-0.012412092,0.016161164,0.014270982,-0.047744337,-0.0036534406,-0.016248146,0.015425248,0.02194399,-0.126829,0.0006959629,0.0031370162,0.04764075,0.07022864,0.059908673,0.009714214,-0.029274406,0.027954083,0.03364593,0.052704502,-0.08056494,0.07591596,-0.029920045,-0.06380835,-0.04957918,0.039980847,0.07156572,0.07943515,0.09174929,0.018759934,0.022803387,-0.01275751,-0.06419282,-0.0030419114,-0.043073677,-0.074516736,-0.041194223,0.00867251,0.024896314,0.07012399,0.026482517,-0.007081429,-0.017625095,0.041265033,-0.013051017,0.014017687,-0.009607819,0.0003386462,0.038658764,-0.026577532,0.113143325,0.0040202653,-0.0035083822,0.0009849358,0.0957519,-0.031090643,-0.061812717,0.030217338,0.009744161,0.045948077,0.030199986,-0.008672279,-0.018850518,0.043412253,-0.05767799,0.050408836,-0.03220122,0.012997745,0.10428851,-0.01391545,0.004229751,0.028496373,0.09400299,0.05995604,-0.06362859,-0.03420989,-0.0017079229,-0.06967177,0.043454666,-0.083137855,3.1005052e-33,0.0038670495,0.055727266,-7.681612e-05,0.03246885,-0.016541759,0.000739544,-0.15002851,0.055418883,-0.086266555,-0.06980272,-0.075716704,-0.053149514,0.023059368,0.01219032,-0.041446958,-0.05442124,0.020382011,0.022369495,-0.044198874,-0.055271626,0.028514666,0.029743375,-0.035862576,0.026008848,0.07993799,-0.0029631048,-0.03291296,0.008195456,0.063004725,-0.01515685,0.0047228727,-0.065181844,0.026680121,0.050289884,-0.054682616,-0.028792085,-0.0036458583,-0.08661948,0.031522933,0.05218936,0.021855041,0.06178264,0.06960947,-0.052672207,0.041148674,-0.023967497,-0.069314696,0.035060063,0.08570751,-0.028829742,-0.00868648,0.042224795,0.0548736,-0.03407457,0.06882947,-0.06479299,0.015907733,0.012339979,0.11692488,0.038370118,0.028121382,0.14417838,-0.06279215,-0.071518645,0.0051110736,0.14217728,-0.059961606,-0.013603751,-0.03969349,0.0308211,-0.056759603,-0.030748459,0.038238846,0.041823562,0.105891794,-0.03882265,-0.114259854,-0.024212677,0.015609396,0.0063217795,-0.115377426,0.037850134,-0.05004913,0.07648263,-0.04488409,-0.057065293,-0.01561414,0.041489113,0.055704523,0.08259196,0.020144183,0.029145082,-0.06233902,0.009118778,-0.010644396,-1.9599835e-33,0.015558984,-0.0029341,-0.027710415,-0.031440493,-0.028321506,0.00654868,0.004909479,-0.023799444,0.10291014,-0.03699154,0.19098063,-0.051096473,0.039402783,-0.090745114,0.041788343,-0.009032645,0.009599565,0.006752886,0.028215768,0.047289383,0.037113164,0.051553134,-0.011324928,0.020194527,-0.008215527,0.01932763,0.039055735,0.049059913,0.024194105,0.024336249,-0.0736285,-0.014373901,-0.026058346,-0.0065619233,-0.11855973,0.027343277,0.064059734,0.008104518,-0.04599909,-0.071059786,-0.04354878,0.025421817,0.010763969,0.08307062,0.07991868,0.02556557,0.041927278,-0.036703736,0.009568992,-0.035507213,0.03517508,0.0032989117,0.0048515424,-0.02985054,-0.009118889,0.013086221,0.011389533,0.029519705,0.00068308355,-0.035282634,-0.034913324,-0.07286328,0.07182465,-0.061299637,0.012278245,0.06351972,-0.10634052,0.13193576,0.061218295,-0.07797099,0.06250491,-0.023353612,-0.0150573235,-0.004318803,-0.059641983,-0.06379597,-0.012683346,0.00012033192,0.06133505,-0.0734504,0.0032986861,-0.006868145,0.011823005,-0.0026932973,-0.01348607,0.05083012,0.017614037,0.013227467,-0.009647933,0.0070668845,-0.015000817,0.023668863,-0.09026017,0.008490659,0.044574223,-2.8043784e-08,0.028440438,-0.0056740968,0.0103718005,0.0027251663,0.079671785,0.037701555,-0.032414887,0.009085615,0.0007859502,0.035894174,-0.004955971,0.059813686,0.0015393556,-0.050085172,0.03486426,0.040491052,-0.06990748,0.08894843,0.0033091167,0.027846714,0.03887805,0.067669734,-0.054501645,-0.040124767,-0.028016271,-0.037023447,0.014486231,0.024605151,-0.047864597,-0.048124105,0.029241467,-0.01675887,0.05481835,0.00029409426,0.01123252,-0.06040687,-0.077883914,0.060732555,-0.013752061,0.013439106,0.0034328417,-0.047722027,-0.060832586,0.02950385,0.007305089,-0.036828812,0.0820206,-0.043654628,-0.0083817225,-0.036562607,0.06784692,-0.048265796,0.08739034,-0.06027667,-0.0016022002,-0.043283463,-0.07007957,-0.07875705,0.012191607,0.00031407576,0.034382734,-0.0756531,0.13892743,0.05773742 +2.3.1.96,"Acts on mucins. Activated by 1,4-dithiothreitol.",384,1.0,-0.044638645,-0.06050658,0.055750266,0.019985883,-0.020379027,-0.041998535,0.087959476,0.08948942,0.14060698,0.021401273,0.037528638,-0.03481252,0.12154403,0.07690607,-0.048334748,0.111509345,0.0020425913,0.03506196,-0.033440392,-0.0011439306,0.061467987,-0.021989688,0.013690888,0.005009865,0.0033567941,0.018117514,0.032690194,0.04540678,-0.006500605,-0.08077139,0.03201504,0.025283612,-0.010138321,0.021359876,-0.02894047,0.031321336,-0.022073539,0.0063690143,0.122976564,0.026353374,0.068304084,-0.04513773,-0.035450242,-0.0362369,0.004103597,0.0020600378,-0.050603874,0.053105976,0.0765508,0.01173548,-0.051496387,-0.028970469,-0.006978573,0.09616857,0.042997204,-0.046012867,-0.13284118,0.040876657,0.055562187,0.00024573226,0.0020641452,-0.04868137,0.046966072,0.012195553,-0.067816466,-0.019526228,-0.041865032,-0.05019361,0.018761722,-0.008295428,-0.029427793,-0.03174749,0.056465607,-0.043868795,0.050818656,-0.02840701,-0.033231694,-0.039600365,-0.059570413,0.005580858,0.003851899,0.00968731,0.060801875,0.01452642,0.071983695,0.0035293289,0.03737822,-0.050972126,-0.011776413,0.021358974,0.004039068,-0.06622561,-0.066391855,-0.047305368,-0.004469872,0.0029714738,-0.08339886,-0.03184456,-0.007094806,0.054333135,-0.05099501,0.0029727055,-0.06330651,-0.047857817,-0.03382464,-0.018645218,0.03496032,-0.06035494,-0.07208233,-0.046233647,0.007439394,-0.07768635,0.021898326,0.023688463,-0.066519514,0.067150995,0.067848824,0.0066779703,-0.016203629,-0.0729683,0.0112216715,-0.045866575,-0.0044965907,-0.011512111,-0.104356006,0.024130084,-0.03239929,-6.7619224e-34,0.027012838,-0.033969488,-0.020894842,0.0541461,0.047987316,-0.025721341,-0.020249603,-0.05223379,-0.044426885,-0.048839927,0.0011103625,-0.05613712,0.03613234,0.039487846,-0.060737792,-0.0876254,-0.01023966,-0.014230675,0.0618229,-0.06930888,0.017135603,0.069433615,-0.02930897,0.0055257105,-0.02598035,0.06925973,-0.05482699,-0.00083203363,0.10158789,-0.0031079166,-0.018131558,0.049472768,-0.044897646,-0.0034992867,-0.028539535,0.075094245,-0.035096012,0.020943213,0.053676777,-0.026412701,-0.044162747,-0.03613392,-0.054589793,-0.026830154,0.06026298,0.023685772,-0.06928384,0.0346317,0.06420155,0.08426006,0.10589669,-0.10601191,0.085184194,-0.05124174,-0.066303246,-0.0036890188,-0.02832937,-0.07792871,-0.01267824,0.015533442,-0.000888209,-0.022121172,-0.08379106,-0.037663624,-0.008101185,-0.0014854581,-0.13990921,-0.049194038,-0.0087314695,0.063069455,-0.0018229868,-0.033841774,0.00315561,0.000393577,0.048372053,-0.021399247,-0.018146452,0.04295873,0.042243913,0.055061065,0.031099629,-0.032695472,0.031755473,0.052579466,-0.041710448,0.03609898,-0.04160777,-0.083104126,0.041443944,0.049297724,0.032321036,-0.040669676,-0.085230075,0.016730888,-0.02634495,-6.1566296e-34,0.036887664,-0.01273891,0.056399964,0.10625224,-0.037508857,0.09317751,-0.034373835,0.007841059,0.026621064,0.026920049,0.09411399,-0.033122636,-0.09634999,-0.03802883,-0.035987437,0.037364155,0.045181688,0.03573607,-0.07911395,0.054824512,-0.030672932,0.04312237,0.019400865,0.009621629,0.043073755,0.05467974,0.087468386,-0.0076214336,0.057252456,0.060463745,-0.09610659,-0.0016951894,-0.05091631,-0.04166472,-0.019176088,0.004384259,-0.03328056,0.025078181,-0.0680395,-0.100558445,-0.024275336,-0.01707013,0.090481356,0.12937191,0.043830432,0.08207422,0.03158635,0.033059787,-0.06820604,-0.017314853,-0.012690219,0.004060623,0.0053374823,0.013128881,-0.004086183,0.03547573,-0.03229146,-0.05086283,0.0077414494,-0.06744443,0.0034037307,-0.027943008,0.0031496226,-0.029086944,0.060998756,0.07746883,-0.050714437,0.044065397,0.08338121,-0.031180546,0.039254773,-0.023756055,-0.0035089895,-0.13709298,-0.017137965,0.0060542864,-0.18094882,-0.09322242,0.019306362,0.04558267,-0.0599214,0.019355252,-0.08302264,-0.09559155,-0.014797669,-0.040923428,0.04405553,0.070286244,0.05335535,0.046095006,0.0072329817,0.07234269,0.004809333,0.040114604,0.02861949,-2.2338337e-08,0.031393506,-0.060773637,-0.022197206,-0.004474659,-0.0048155203,-0.010995526,0.007049883,0.042810615,0.012924429,-0.019675365,-0.02139981,0.07692325,0.036172267,-0.0021367187,0.082647875,0.062237423,0.009055708,-0.021553311,0.0010495319,-0.05331087,-0.077033624,-0.013559055,-0.022870507,0.053620853,0.04977912,-0.040552605,0.00092877564,0.02940641,-0.038355324,-0.029195916,0.117737815,0.021549897,-0.058958523,-0.05011366,-0.083978646,-0.010871114,-0.05604909,-0.018750248,0.012215971,-0.013930403,0.025392275,0.03434822,-0.045790885,0.026348231,-0.10364618,0.036648046,-0.0218118,-0.012308261,-0.0034349575,0.046616055,0.01707459,0.012259204,0.036694147,0.042832106,-0.13466312,-0.0011446152,0.08122055,-0.044162843,0.023020115,-0.10038732,-0.025384517,0.036824614,0.10537789,0.039744783 +2.3.1.97,"The enzyme catalyses the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.",384,1.0,-0.009382877,-0.061446976,-0.02980061,-0.07842292,-0.0058484925,0.017473582,0.01988633,0.09635942,0.09008443,0.004138788,-0.010282196,0.02844111,-0.0082124155,0.05307463,-0.0612759,0.009428126,0.032175556,-0.02991821,0.0035652744,-0.016613634,0.0047883163,0.046507105,-0.054966986,-0.010306728,0.007923779,0.018471345,0.048394624,-0.059281997,0.025123257,-0.114903644,-0.056035176,-0.065477915,0.03643731,-0.008840076,-0.023060173,0.09340523,-0.045096096,-0.07554567,0.07689427,0.019266708,0.078765094,-0.059420105,-0.011939003,-0.033054095,-0.0055465633,0.036095724,0.009057971,-0.014650298,0.0036441735,0.07634429,-0.012191073,-0.04938599,-0.027950563,-0.008191631,-0.040975943,-0.006682904,0.023142204,0.03577002,0.015946172,0.07168095,-0.035124578,0.010059415,0.040220466,-0.01735592,0.037058406,-0.0930807,0.051049102,0.024082216,0.023413083,0.022430286,-0.015977914,-0.04837249,-0.030411664,-0.0067994855,0.028646478,-0.069468305,-0.0017763752,-0.030774571,0.01695017,-0.035297584,-0.09456555,-0.020826427,-0.03224409,0.067064896,0.048896156,0.02247177,0.013012268,0.03163412,0.06340663,0.045309987,0.07427712,-0.05502314,-0.04130252,-0.018888442,-0.078304544,-0.06773967,0.05927817,0.026598224,-0.06740123,0.0039486494,0.06956633,0.13191158,-0.059382897,-0.049012367,-0.015936514,0.081697375,-0.014352181,0.018302709,0.010035542,-0.016417516,-0.018030586,0.025561346,0.044679925,-0.005273508,-0.03132482,0.10502864,0.031779088,0.0059048915,-0.022849966,-0.0014950865,0.01154034,-0.02464553,-0.016670883,0.08570684,-0.12639633,0.07921945,-0.012864895,-5.441088e-34,0.02889355,-0.007546442,-0.038882326,0.035468683,-0.015827626,-0.074925475,-0.088412486,-0.0058368067,-0.017596299,-0.0730866,0.024606945,-0.06636635,0.05534409,0.114097364,-0.11271416,-0.054505616,0.029833028,-0.017924782,0.08187237,0.005857045,0.010479647,0.003861365,0.02636507,0.020809975,-0.01703083,0.04045973,-0.042803098,0.03823593,0.021416297,0.0102182375,-0.022125544,-0.08370985,-0.14229792,0.018158242,0.056756344,-0.032139875,0.04321926,-0.08334822,0.071011685,0.009558723,0.019710373,-0.0072134677,-0.0020660039,0.04929727,0.0683601,-0.015466996,-0.0055246456,0.08568167,0.0009617869,-0.05412853,-0.00054069964,-0.06885942,0.09332634,-0.03872339,-0.07114351,0.0016486865,-0.01575881,-0.024817808,0.0011801042,0.06077695,0.0068865665,0.09955017,-0.018283222,0.11159923,-0.006684258,0.04755696,-0.086105034,-0.053525377,0.070736006,0.026859827,-0.03409623,-0.0060053393,0.057279114,0.036844335,-0.018122662,-0.05324591,-0.08334954,-0.03883207,-0.0074948203,0.0059187114,0.022130381,-0.014291661,-0.05886474,-0.04882404,-0.006368666,0.05577312,0.07979522,-0.12796587,-0.04530273,-0.0494314,0.02361167,-0.043550156,0.061359756,-0.027138088,-0.0143092945,-1.6453852e-33,0.06729144,-0.12907651,0.06306843,-0.041551165,-0.12575664,-0.04841036,0.02712985,-0.04863465,-0.037805792,-0.005690729,-0.0062111327,0.00791831,-0.022542858,-0.019910164,0.014356203,0.020599158,-0.022246957,0.03422617,-0.023374395,-0.10332049,-0.062441096,0.054088928,0.04896409,0.07047138,0.034001954,0.015036334,-0.036104124,0.0550677,0.055096723,0.042385112,0.0063410015,-0.01176095,-0.052229274,-0.037951924,0.0035173795,0.09335361,-0.065973826,0.01717012,-0.03895605,-0.0356672,-0.015436634,0.085988365,0.027247593,0.05315272,-0.013405298,0.028322961,-0.12664966,0.046400197,-0.02980697,-0.050651807,-0.006253435,0.012774024,0.023404932,-0.059051823,0.009511847,0.07223493,0.025914235,-0.004517757,0.011099348,-0.047621142,0.0007563804,-0.034536008,0.032673717,-0.055113588,0.082843475,-0.014234048,0.015765121,0.017588627,0.10367332,-0.021403976,0.059531465,0.02953254,0.09005124,0.06707166,0.02662335,0.002232203,-0.0164629,0.013150399,0.015570143,-0.08882272,-0.09874171,-0.028998261,-0.026607819,-0.07323522,-0.018682126,-0.10519612,0.050580706,0.15296605,-0.03195773,-0.026120417,-0.0037559604,-0.0048780357,-0.03683014,0.029941533,0.030756772,-3.8450832e-08,0.1151463,-0.076014414,0.051616192,0.0030571702,0.010135477,0.036109883,-0.054490697,-0.09124264,-0.035012115,0.015790567,-0.06972769,0.07821123,0.03346377,-0.028834607,-0.023315044,0.08973744,-0.0071810596,0.0018734307,-0.028835585,-0.06771744,-0.027144598,0.011093573,-0.035508458,0.0016036289,0.049987867,-0.0295722,0.049703415,0.117099866,-0.010311403,-0.054374926,0.022601005,0.009254078,0.036971923,-0.015790302,0.04749585,0.07698843,-0.036074933,0.009074497,0.02767221,0.021719048,0.04836053,-0.058949824,-0.051013935,0.041390534,-0.05080213,0.0021831808,0.029789427,0.03597427,-0.024901858,0.05512675,0.04095572,0.024708398,0.028811552,0.046016023,-0.06499716,-0.0032188203,-0.065065555,-0.075819224,0.04928325,-0.050204773,0.054269575,0.0734576,0.07633431,-0.12466351 +2.3.1.98,"Galactarate can act as acceptor, more slowly. Involved with EC 2.3.1.99 quinate O-hydroxycinnamoyltransferase in the formation of caffeoylglucarate in tomato.",384,0.99999994,-0.008643337,-0.080484584,-0.054888,-0.0071892138,0.048703738,0.0048774616,-0.011264213,-0.010544382,0.03909924,-0.052458055,0.098723,-0.093437254,0.01883324,-0.021349635,-0.058952812,-0.0070400774,0.06078993,0.023108307,-0.03146262,-0.00069117075,0.05166379,-0.029416436,0.01879079,0.036622558,0.03785104,-0.017976437,-0.046591617,-0.02559679,-0.046800897,-0.15708266,0.0056666858,0.09992682,0.058118,0.0036515673,-0.065785475,0.07665934,0.03202801,-0.084958345,0.08686812,0.013658909,0.0003366942,-0.03969409,0.036520414,0.008341667,0.012460294,0.012738801,-0.022920646,0.0073233577,-0.02449228,-0.08813771,-0.057212256,-0.07219131,-0.048076734,-0.03385038,0.054969303,0.08710024,0.037081763,0.03311757,0.042691775,0.065314904,0.0038478742,-0.030426499,0.0016345879,-0.010057007,-0.06538595,-0.05405094,0.01009761,-0.056685656,0.01915013,0.030936161,-0.03974838,-0.009705296,0.017930046,-0.030120486,0.026593892,0.07501417,0.0029403386,-0.0149897095,0.057383165,-0.020235151,-0.023257412,-0.0461957,-0.05421274,-0.03352794,0.037067384,-0.06850444,0.04969342,0.024884274,-0.03192528,0.09355839,0.063118994,0.015016883,-0.0017302317,-0.023550218,-0.046790995,0.03333392,0.03374009,-0.10898016,0.012120217,-0.04967856,-0.008382783,-0.061176475,-0.013618088,0.014562096,-0.016511714,0.0016163292,0.012141843,0.0052742045,-0.0058700866,0.039267987,-0.031903554,-0.049742147,-0.009240644,0.051945057,-0.08357559,0.10104564,0.001519716,-0.060451552,-0.038889002,-0.050949074,-0.03895491,0.0090255095,0.047843143,-0.03367858,-0.041361623,0.015564969,-0.0074536446,4.2345285e-33,0.006788369,0.05090184,-0.033851728,-0.051923666,0.0016749407,-0.004956357,-0.08609642,0.045783885,0.038344473,-0.09378465,-0.12043419,-0.012853122,0.0016201979,0.09334061,-0.052360177,-0.020746917,-0.024708265,0.019443432,-0.0446755,0.009462471,-0.0008943706,-0.021180706,-0.06407997,-0.082105465,-0.026786746,0.042606648,0.0024645724,0.024995418,0.10079678,0.012707929,0.07527256,-0.07335858,-0.010323112,0.06351688,0.02246328,0.047620375,0.054350667,-0.07897117,0.025723355,0.020327248,-0.022164162,0.08577062,-0.0023386625,0.04502524,0.03884495,0.009756659,0.030266592,0.08041533,0.00510577,0.01567921,0.015323138,-0.029932795,0.009501357,-0.023280416,0.03164381,0.04632266,-0.039071098,0.04759952,0.021282244,0.026470968,-0.01596511,0.09006614,0.010751112,-0.011158984,0.010427774,0.10344596,-0.10847346,-0.040492035,0.015968826,-0.0095764045,0.010796199,-0.108412035,0.041166905,0.038838517,0.021031402,-0.044566642,-0.025021486,-0.028091291,-0.028145647,-0.0013301594,0.005338656,0.015206528,0.04042103,-0.009329923,-0.049340717,0.038538396,-0.020323902,-0.015991531,0.06425261,0.0957058,0.008739111,-0.0458881,0.042209774,0.017883541,0.04451843,-3.5340995e-33,0.105484955,-0.008273641,0.037333634,0.026787566,0.012643843,0.06469908,-0.01779932,-0.070840836,0.028185427,-0.08909395,0.026275164,0.031090625,0.043219257,-0.075270586,-0.0034843225,-0.06916539,0.05222249,0.100191206,-0.11716219,0.033770297,-0.07936412,0.00952336,-0.008836168,0.032398403,0.008285982,0.013476158,0.0013255468,-0.018489929,-0.05941718,0.050340038,-0.04541856,-0.031016324,-0.08067692,-0.026732964,0.062085953,0.004965095,-0.0768304,0.01786668,-0.056995064,0.06094644,-0.10032619,0.044948973,-0.027389007,0.058209747,0.029289728,0.06734492,-0.03391931,0.010003417,-0.0004479062,0.05368645,0.024854343,0.022933088,-0.044354577,0.052219275,0.026275896,-0.0066718976,0.061473355,-0.009325613,0.012202303,-0.024894973,-0.05078976,-0.045335952,0.06276176,-0.13800447,0.0686914,0.062279124,-0.009150645,0.14074354,0.085519396,0.0130326785,0.12289083,-0.0012656258,0.020045396,0.041611437,-0.018344143,0.07107535,-0.09229175,-0.073250785,-0.05122677,-0.010847998,0.072767325,0.062452335,0.010998649,-0.05623442,-0.05515422,-0.07693714,0.013849357,0.043049477,-0.018735718,0.0547816,-0.057652853,-0.019669103,0.013817747,0.06279521,0.16904192,-3.3224712e-08,-0.004436636,0.008078446,0.056668475,0.03419966,0.017330956,0.04314374,-0.0680044,0.0032388237,0.043650944,-0.07041251,-0.084239155,0.11911895,0.008389946,0.015033449,0.016568344,0.011231496,0.06483979,0.045683432,-0.011960115,0.082364514,-0.12346383,-0.0031691978,-0.09088681,-0.06939194,0.017864337,-0.080352955,0.05019894,0.034845836,0.022492656,-0.05417941,0.03431772,0.0036842932,-0.006846736,0.0043814066,-0.047433432,0.07765233,-0.021785287,0.055540018,0.0068411105,0.03800919,0.018704353,-0.056391917,-0.04485711,-0.014954937,-0.0841999,0.011854145,-0.016100291,-0.029555986,-0.0800184,0.07560895,0.047166795,-0.021248687,0.051731452,-0.049156956,-0.041752093,0.0003087821,-0.0021515558,-0.06634778,-0.03442078,-0.02173049,-0.057047796,-0.01091193,0.16018543,-0.006408796 +2.3.1.99,"Caffeoyl-CoA and 4-coumaroyl-CoA can also act as donors, but more slowly. Involved in the biosynthesis of chlorogenic acid in sweet potato and, with EC 2.3.1.98 chlorogenate---glucarate O-hydroxycinnamoyltransferase, in the formation of 2-O-caffeoylglucarate in tomato.",384,0.99999994,-0.06287639,-0.043569464,-0.10605269,0.00046622808,0.0899085,0.07258812,-0.05301236,-0.0062105795,0.07370359,-0.055679724,0.08580069,-0.09803073,-0.020100744,-0.05058928,-0.06690198,0.031778168,-0.013203001,0.039242554,-0.07028036,-0.07133732,0.03104873,-0.046108104,-0.0017172453,0.0051092873,0.046548676,0.023420967,-0.0100312885,-0.07532576,0.009312932,-0.10205594,-0.06607983,0.049633767,0.019122828,0.025037965,0.00075297186,0.08318848,0.057916455,-0.09035319,0.08735187,0.054422177,-0.0012236933,-0.07521268,-0.035313632,0.045294516,-0.009669985,-0.0052792425,0.007857264,-0.051088512,0.0016690282,-0.058010586,-0.016801717,0.02316974,-0.029882235,-0.042197865,0.044257067,0.015997352,0.08343109,0.048968274,0.057598196,0.08932394,0.021747043,-0.06460976,0.030118398,-0.024686005,-0.04640507,-0.045060296,-0.0076708677,-0.042584326,0.04130573,-0.06668159,-0.026341174,-0.042091634,0.036418613,-0.021590235,-0.000753993,0.082118616,-0.01491042,0.07585814,-0.0013253328,-0.0048519433,0.023899898,-0.024684792,-0.009504759,0.027695587,0.005260573,0.002923309,-0.043991968,-0.029735267,-0.004058343,0.10653838,0.014856837,0.003027169,0.0412372,0.03259693,-0.10003497,0.0450495,0.06951937,-0.10549705,0.0026085863,-0.046602905,-0.06864046,0.030833108,-0.04226922,-0.0031660534,-0.03016364,-0.034317672,-0.06267058,0.008833968,0.018487267,-0.007199933,0.00858909,0.019458126,-0.03269773,0.037788164,-0.023511974,0.061751805,-0.061781224,-0.02614611,-0.012798445,0.030538103,0.0049951486,0.002309021,-0.008830973,0.016756099,-0.040018372,-0.008062515,-0.02250477,3.358216e-33,0.078000546,0.09359869,-0.00591852,-0.0060835406,-0.007951348,-0.07884907,-0.05690721,0.026081614,0.037617177,-0.10234902,-0.008660742,-0.03998007,-0.015978293,0.014238438,-0.040465947,-0.035553865,-0.066600636,-0.041489072,0.04229962,0.025822472,-0.024291214,0.013686948,-0.019764822,0.033803683,-0.027986126,0.029591933,-0.030651968,-0.009736444,0.09936278,-0.004614906,0.011041797,-0.021905122,0.020526368,0.035759177,0.01754237,-0.05426164,0.011846722,-0.061897524,-0.020547276,0.1155705,-0.034967434,0.00068546645,0.0007215577,-0.01889308,0.06173059,-0.052707113,-0.019230194,0.04142562,-0.01220583,0.048757512,-0.055743977,0.010435876,0.06737561,0.053885285,-0.0043914253,-0.0051719365,-0.04506357,-0.05976895,-0.0009129685,0.020888414,0.014146989,0.0587304,0.016203338,-0.041896917,-0.029706247,0.022910262,-0.097873315,-0.054890152,-0.009152586,-0.004694636,0.04435559,-0.091047,-0.00993047,0.055617023,0.06990071,-0.04127311,-0.00980116,0.04814436,0.021592967,0.0012008549,0.0363518,0.061047483,0.094827965,-0.016589642,-0.08771936,0.025189742,-0.049073283,-0.10008401,0.02532689,0.04700058,-0.032978214,-0.03255201,0.057035945,-0.043821473,-0.010167428,-2.7220186e-33,0.15826464,-0.040823296,0.025491927,-0.054308042,-0.010907489,0.009943759,-0.08154227,-0.1286549,0.015250539,0.044184934,0.050731696,0.02902639,0.024515929,-0.03685279,0.009752066,-0.002424265,0.037424274,0.105794914,-0.10143666,0.016281718,-0.020373024,0.037502095,0.061820626,-0.018391537,0.076599516,-0.0010325848,-0.011791486,-0.015151256,0.013494686,0.03244966,-0.004129665,-0.06904961,-0.04514384,0.04576865,0.059883013,0.011677151,-0.0007378563,0.035184346,0.00551487,0.10797775,-0.102369696,-0.015801236,0.02042308,-0.03180981,0.024554344,0.010915092,-0.062355544,-0.006136333,-0.00782839,0.013614999,0.040650323,0.100403264,-0.12073553,0.011581521,-0.014494485,0.004022069,0.07788529,0.01804748,0.024699457,-0.07200111,-0.041902635,-0.042084,0.0055955774,-0.042819843,0.07813728,0.057343964,0.026513575,0.13322613,0.06297941,0.019694954,0.09147138,-0.0341255,0.085335016,0.041523997,-0.010575924,-0.019363657,-0.036246687,-0.035393286,-0.011919508,-0.03525178,-0.050656468,-0.02021195,0.038975943,-0.045501128,-0.08455146,-0.08358622,0.051572334,0.009952513,-0.0065056263,0.05477476,-0.08145801,-0.021189205,0.04004521,0.11168677,0.16525929,-3.8023945e-08,0.011671345,-0.022442987,-0.006924512,0.052289855,0.07658057,-0.011230711,-0.09801203,-0.019474074,0.06697532,-0.0031386989,-0.13056393,0.06889778,0.042408198,-0.0037497927,-0.025379531,0.0050555575,0.060596406,0.037173413,0.041240998,0.036757294,-0.12582184,-0.008864223,-0.09237283,-0.024565827,0.0041707032,-0.08508514,0.06126338,0.014780462,0.06550639,0.038148914,0.020609673,0.010958898,0.023646755,-0.08188974,0.024053607,0.007699304,0.0016613789,-0.037933122,-0.013965279,0.06926583,-0.03769605,0.012349863,-0.063316286,0.047432736,0.016467104,0.008282501,0.0016565993,-0.014418632,-0.060017418,0.032816634,0.049257446,0.018200126,0.03280277,-0.026241092,-0.041331537,0.037202753,0.05199951,-0.032127287,0.050879624,-0.022053162,-0.087918945,0.049319025,0.17858268,-0.04665251 +2.3.1.100,The enzyme in brain transfers long-chain acyl residues to the endogenous myelin proteolipid,384,1.0,-0.042932212,-0.06843221,-0.058672328,0.004382157,0.071757324,-0.0007511206,0.01619537,0.024228795,0.014757769,0.0042611435,0.08538774,-0.024102006,-0.1127709,0.06041981,-0.011410352,0.008521492,-0.080246635,-0.09025982,-0.025603559,-0.046391327,0.030793278,0.02735436,-0.0654131,-0.04514326,0.010013571,0.011290332,0.06279943,-0.005177858,0.054097757,-0.03804475,0.016342185,-0.08702822,-0.06470498,-0.001402417,0.047528673,0.046821892,-0.11079693,-0.049974076,0.033088837,-0.041772135,0.1231514,-0.028555315,-0.05414939,0.051119767,-0.041728295,-0.017361915,0.007432859,0.0044300784,0.016575955,0.040574845,-0.07091048,-0.04295992,-0.026593862,0.049483947,-0.0987794,0.02870045,0.01187423,0.012025324,-0.050180186,0.08033008,-0.061540358,-0.02601715,-0.029943066,-0.006282043,0.008120569,-0.010928264,-0.030390188,-0.05307424,-0.11171797,-0.008345254,-0.051943272,-0.0901701,0.0025570318,-0.010298112,0.10057909,0.0017826139,-0.058118723,-0.054660212,0.013608142,-0.063102715,0.021238811,-0.011045524,-0.0069304034,0.024010206,0.10612061,0.01921958,0.035508275,0.078943454,-0.035934824,0.021588732,0.009737784,-0.090845175,0.00028129068,0.020499311,-0.03523718,0.03802503,0.020728106,0.022404747,0.0051540043,-0.00502432,0.01838976,0.059815712,0.009623117,0.020250173,-0.058317788,0.092147306,0.04396069,-0.000108425695,-0.05022377,0.006156301,-0.0015675768,0.017214563,0.049415097,0.033589717,0.08242069,0.0054424857,-0.14059523,0.075275026,0.07374244,-0.04166356,0.0005508648,0.049171876,-0.055144746,0.023670694,-0.02476952,0.06020092,-0.050230455,3.7098195e-34,-0.04163178,0.058649085,-0.07593871,-0.0050653187,0.0058966884,-0.046140775,-0.07181203,0.048875958,-0.020815257,0.0673246,-0.014797355,-0.09097535,-0.035143077,0.047372542,-0.014934152,-0.018396614,0.021529859,0.030246686,0.09214679,-0.009168279,0.04041649,-0.03285481,0.02154407,-0.004077906,0.044976916,-0.02495631,-0.08593735,0.08845455,0.018712489,-0.005796038,-0.07505152,-0.05025634,-0.04483263,0.01706258,0.023515068,0.031050546,0.046284206,-0.057428297,0.034779537,0.03302949,0.03854723,-0.008431833,-0.011942198,-0.020469911,0.011641181,-0.05150612,-0.092660315,0.047182027,0.021174174,-0.040335175,0.04611101,-0.06123596,0.06029026,-0.010626746,-0.06308505,0.021956662,-0.08092968,0.044237576,0.059335392,-0.020895189,0.04155029,0.014815426,-0.058667548,0.060698688,0.07922487,0.05873714,-0.081089474,0.015916958,-0.043864958,0.020243464,0.021290783,0.021526368,0.03725842,0.013377707,-0.0014156431,-0.020833425,-0.03738929,0.0053910716,-0.0018175009,-0.041579824,0.027540283,0.04031151,-0.014606993,0.009273043,0.010806776,-0.051636636,0.015592159,0.005207654,-0.01595593,-0.061821856,0.018063068,-0.0076310607,0.028189356,0.02628359,-0.06501271,-2.2618477e-33,0.06214745,-0.07415497,0.083563484,-0.12214309,-0.0315279,0.039201993,0.12808163,0.055493858,0.07288037,-0.005634436,0.06098312,0.020028051,0.011026506,-0.08738357,0.065944396,0.0022758525,-0.094294466,0.039637476,0.092335604,-0.08788778,0.0013970125,0.09861798,0.025404928,0.045896538,0.03036518,0.02817475,-0.021613708,0.060500257,-0.009378575,0.10676782,0.008499927,7.1887654e-05,-0.06708076,-0.08786682,-0.021597482,0.08334707,-0.031771977,-0.011894419,-0.03420699,0.04635687,0.0006886695,-0.0038947093,0.07197318,0.0010793468,0.050905026,-0.004309312,-0.064190336,-0.002124108,-0.0426573,-0.09725788,-0.03379507,0.05524332,-0.057634134,-0.06841058,-0.018993406,0.09038108,0.042387933,-0.021229427,0.06996045,-0.16304201,-0.07148873,-0.005853373,-0.027901731,-0.0062844693,0.04941079,-0.04983912,-0.014006793,-0.0509863,0.06295606,0.02211377,0.054526933,0.123757385,-0.105982415,0.010781068,-0.0054959864,0.021732291,-0.018983359,-0.010404536,0.0524749,-0.0056388946,-0.0074095577,-0.0061768657,-0.052526828,-0.013285749,-0.017553456,-0.06738897,-0.051680952,0.026679715,0.04234352,-0.0097289365,-0.0075758947,-0.021658747,0.0013994143,0.029613955,-0.018291725,-2.4297252e-08,0.081610434,0.022283513,0.055439815,-0.021218631,-0.00070881384,-0.052986216,0.03965296,-0.005396897,0.011170855,-0.019571546,-0.07396979,0.019916363,0.047288004,0.02386664,-0.07597662,0.09252539,-0.037857343,0.030351002,0.01881529,-0.1056558,0.05488691,-0.009696103,-0.029095199,0.030998103,0.0053098067,-0.012979569,0.006651998,0.057897903,-0.0814745,0.023544291,-0.008470579,0.01989109,0.0195888,-0.012237073,0.08220544,0.01145841,0.064918816,-0.0143557815,-0.036251843,0.023469374,0.058924895,-0.07959242,-0.04246629,-0.008100357,0.0330803,0.0482832,0.025927054,0.014416352,0.07693523,-0.0061001373,0.011525051,0.015223147,-0.046966705,-0.011592539,0.010632797,-0.059203494,-0.091075696,0.028020484,-0.025571406,-0.10703089,0.06337446,0.12104484,0.14732133,-0.1248132 +2.3.1.101,Methanofuran is a complex 4-substituted furfurylamine and is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum.,384,1.0,0.0026043374,0.007205022,-0.10908025,0.061251964,0.026279181,0.0014520983,-0.028388599,0.07539189,0.03212076,0.0069709965,-0.04739752,-0.13630871,-0.041245736,-0.014133648,-0.009170867,0.018153004,-0.035814025,-0.07416481,0.03672664,0.018964758,0.08492162,0.07042616,-0.00013337728,0.0055840197,-0.050838843,-0.0014695567,0.0037615206,0.023105891,0.008094708,0.040140055,0.069739565,-0.009293219,0.07355728,0.011243272,0.030853922,0.015389873,0.079011254,-0.04164426,0.10566783,0.043135945,-0.009823818,0.03817698,0.15267353,-0.0087182205,-0.018737838,0.005211514,0.0077688,-0.018967262,0.030801501,-0.08908549,-0.03221889,-0.034216244,-0.059020407,0.0760713,0.049161635,0.028314173,-0.0521552,0.02554637,0.020067263,-0.027511882,0.08117767,0.008286166,0.040904053,-0.0093797315,0.026314992,-0.054728236,0.017013442,-0.07288862,0.12640281,0.029589225,-0.043666966,0.05639701,0.01631963,-0.11350876,-0.037020944,0.008669358,-0.009161876,-0.03062267,0.077144615,-0.0724022,0.02685625,0.0536164,0.037344493,-0.04110865,-0.011989086,-0.011106854,0.043331712,-0.058871318,0.0806135,-0.03617042,-0.07782858,-0.007879966,0.033012502,-0.011480342,-0.1416478,-0.03333945,0.15228674,0.07850396,0.049104095,0.058150277,0.015202146,-0.025882104,-0.099036984,-0.08260365,-0.13356096,-0.007919757,0.07805147,0.08235097,0.057860248,0.03296348,-0.028172567,0.018118663,-0.010765302,0.037507012,0.03293518,0.049924083,-0.008361672,-0.09939373,-0.015857091,0.013454187,0.00054547633,-0.04350647,0.08218953,-0.030782547,-0.056913577,-0.033789717,-0.026544299,3.285954e-33,0.062156685,9.8805634e-05,-0.02778449,-0.0015270371,-0.009157797,-0.07643519,-0.048949562,-0.078277595,-0.014741799,-0.0026370506,-0.03747289,0.027743593,0.0395868,0.0128086265,-0.09601992,-0.04062643,-0.04844176,-0.055670854,0.043488912,0.032512378,-0.03782187,0.07304123,0.021556396,-0.013415671,-0.03556439,0.03220844,-0.000855038,0.012746601,0.054089837,0.017102875,0.02210326,-0.016691443,-0.1317218,0.054963417,0.040508952,0.033716314,-0.11636971,-0.01616547,-0.009006213,0.014808567,0.04395861,-0.018706799,0.04332225,-0.037989795,0.04026256,0.065710254,-0.04728294,0.11519983,0.021804824,0.0202464,-0.05005204,0.015994845,0.052515518,-0.02296453,-0.043727025,-0.047553115,0.049143083,-0.082281455,0.010207458,0.004574639,-0.05853564,-0.012957341,-0.008656644,0.026248515,-0.02452843,0.012454423,0.009424315,0.003537794,0.12607917,0.023879617,-0.008603781,0.010584098,0.018411957,0.11231569,0.063082464,-0.0384585,0.029837854,0.005381762,-0.03956598,0.09203492,0.04177384,-0.023431025,0.032772206,-0.06925292,-0.052215133,0.0026153808,-0.056829788,-0.013216469,-0.028872846,0.076086,-0.06510288,-0.08326567,0.053365424,0.00515241,0.024325874,-3.420681e-33,0.04820095,-0.00037012174,0.0012160463,-0.059552316,-0.079805054,0.04779641,0.010963406,-0.065770626,-0.0444677,-0.043780472,0.16593254,-0.052313566,0.04470466,0.0013570088,0.06968101,0.028101694,-0.023030318,-0.007024602,0.025082164,-0.034909405,0.0057740547,-0.0037716932,-0.16331157,-0.062111106,0.014016505,0.018003294,0.025791181,0.004263393,0.006500486,0.0008245669,-0.021118471,-0.0504782,-0.10348259,-0.042698953,-0.08590655,-0.0057585905,-0.029231869,-0.049351905,-0.06450982,-0.04508442,0.033010427,0.02222275,0.009188598,0.064005025,-0.0146878045,0.031634323,-0.08691886,-0.07914876,-0.007417431,0.065634176,0.029213976,-0.103343464,-0.06284644,-0.10245299,0.012786783,0.09682201,-0.03698996,0.056411542,0.00058218034,-0.023291433,-0.0038498144,-0.030199325,0.072716415,0.01666649,0.010089532,0.028544983,-0.039301902,-0.017258154,0.06531643,0.030458586,0.08202422,0.08655085,0.038909204,0.016570102,-0.012057578,-0.065765224,-0.05858458,-0.022195907,-0.021272175,-0.017529858,0.06352227,-0.03418597,0.08257126,-0.049228266,0.047072247,7.760262e-05,0.051363826,0.029593552,-0.058308084,0.031000806,-0.007141245,0.020029139,0.005118231,0.007498351,0.05675112,-2.818609e-08,-0.004913815,-0.044790346,0.020314775,-0.024642251,0.018763052,0.09273139,-0.017352458,-0.005997927,-0.03328625,-0.016358286,0.03327234,0.05050309,0.07319069,0.0028454147,-0.083904535,-0.013011548,-0.02128308,-0.04964452,-0.012703801,0.0032425558,-0.026650202,-0.04106733,-0.04114461,0.0062910705,0.06336355,-0.026286552,0.0176435,0.09251858,-0.03311697,-0.046481673,-0.02564362,0.032564785,-0.0051634293,-0.04015948,-0.043699346,-0.018564215,-0.036409978,-0.03364614,-0.05986717,-0.046888046,0.08581919,0.093157455,0.0059147654,0.044221517,0.05418765,-0.048188895,-0.064029664,0.06373601,-0.01461943,0.020708008,-0.016804514,0.013226501,-0.016268527,0.01221652,-0.048466407,-0.033734318,-0.00074814894,0.038498536,-0.07849786,0.029406942,-0.0022773338,-0.0004126657,0.05871658,-0.036705494 +2.3.1.102,Involved in the synthesis of aerobactin from lysine in a strain of Escherichia coli.,384,1.0,-0.013689885,-0.07648297,-0.073386244,0.02723694,0.06292546,0.057169646,0.00013477434,0.00787485,0.052211426,-0.015512101,-0.05434501,-0.054759078,-0.028632103,0.029244784,-0.027262378,0.039249353,-0.060654413,-0.019045666,-0.03645959,-0.011016289,0.06502937,0.073943414,-0.032232188,0.006848058,0.011278467,-0.04026913,0.049331725,0.0013722748,-0.06485601,-0.011741662,0.054951955,-0.031922106,-0.01253935,-0.0898428,0.08506225,-0.028989311,0.04592712,-0.063654974,0.16976105,-0.030312771,-0.0051746406,0.06735925,-0.015453025,0.008180111,-0.0684322,0.015604492,0.031029008,0.04438922,0.099103436,-0.003442479,-0.056352988,-0.02709398,-0.022165867,-0.0029612132,0.0378946,0.0035291538,-0.07732423,-0.03973349,0.036655046,-0.026849618,-0.040404063,0.037229117,0.11537061,-0.017852541,-0.0137517555,-0.10507668,-0.022861881,-0.0013916414,0.07165608,-0.045281537,-0.057676386,-0.049277104,0.035315614,0.08306335,-0.012610992,0.046572637,0.038013145,0.006585772,0.01356917,-0.0096385535,0.007023707,-0.11546106,0.020075003,0.09520822,-0.019786412,-0.0897806,0.032345966,0.02931989,0.028467542,0.06847633,0.078952715,-0.03854476,0.07678643,-0.09100497,0.063416034,-0.092001945,0.02304511,-0.027344044,0.051453624,-0.039930493,-0.0795055,0.019399894,0.08564841,-0.008001814,-0.038344823,-0.051035512,0.08947548,0.06546042,0.08582564,-0.08234935,-0.0055542993,-0.00074558874,0.042072337,-0.015838483,-0.020931218,0.007882442,0.05427521,-0.064445294,-0.1089478,-0.014879953,0.049887154,-0.06400097,0.07476585,0.050225645,-0.12486546,0.014396428,-0.08170166,-1.30594915e-33,0.06939016,0.014650387,0.022210822,-0.03333749,0.038722653,0.040764373,-0.064139634,-0.018729916,0.061550096,-0.055460725,-0.14445786,-0.10352808,0.041378364,0.029433027,-0.008486646,-0.015284317,-0.10441206,-0.056424093,0.018248456,0.035307564,-0.024697663,0.0025373425,-0.009201312,0.000710984,-0.031128561,0.040392887,0.004913484,0.017736254,-0.006921134,-0.0011462452,-0.011719753,-0.03853686,-0.07119867,0.051577006,0.013703248,-0.0036476597,-0.019914035,-0.03158135,0.06381513,-0.0017228781,0.027518285,-0.011175125,-0.0059814746,-0.037614908,0.04154527,0.05371381,-0.10178306,0.05910419,0.0002817317,0.011886866,0.028687293,-0.05823639,0.054519422,-0.07636594,-0.023307325,-0.006549436,0.0127711315,-0.003790054,0.074072406,-0.022842571,0.0461655,0.10901124,0.007714198,0.083429374,-0.01636021,0.018908555,0.023308,-0.01601077,-0.0020541768,-0.003475286,-0.052845284,0.019143596,0.03144829,-0.011946206,0.024858367,-0.039279267,-0.035344657,0.011856907,0.06528525,-0.01678911,0.10660825,0.015423217,-0.014972223,0.0138309775,-0.01764718,-0.04646693,-0.054060146,0.03895199,-0.017521355,0.089937046,-0.038109433,-0.06040888,-0.00885448,0.029908,-0.023715213,-1.4210429e-33,0.057431217,-0.06994518,0.015328153,-0.032486033,-0.047601122,0.044906296,0.014494367,-0.01376029,0.0033349202,-0.07413463,0.038379006,-0.023286512,-0.008571584,0.024872672,0.01936173,0.042809706,-0.04767139,-0.03752714,-0.03684906,-0.039092038,0.01392466,-0.1031676,0.01182853,-0.07011429,0.031576876,0.01809788,0.023477392,0.041230187,0.03787072,0.021491788,-0.033492498,-0.011740515,-0.047580488,-0.068862006,-0.04752444,0.036961447,0.024600103,-0.010187856,0.054272648,-0.12809682,-0.006205747,0.00890356,-0.022324037,0.035480645,0.030354725,0.077683166,0.0010897474,-0.11186675,0.022126114,-0.036689043,0.0072839255,-0.043086115,0.040649958,-0.015347509,-0.0029069495,0.036981802,0.08752107,0.01022301,-0.020565199,-0.003732742,-0.06232754,-0.021132108,0.03616054,-0.0099774385,-0.02758065,0.040859424,0.0023053163,0.071712025,0.07764921,-0.10419444,0.07803245,-0.0025844953,0.102518335,0.081975795,-0.010770304,0.048245676,-0.010963734,-0.05830886,0.012732458,0.014474355,-0.018369066,0.037787404,-0.03256519,-0.06247917,-0.0038545085,-0.03184729,0.02246987,0.07687733,0.034064732,-0.024870748,0.028471787,-0.012574624,0.0142905535,0.008174297,0.107046306,-2.3448889e-08,-0.014886802,-0.08418658,0.07475723,-0.024227673,0.020444527,0.10651251,0.003345695,-0.004880746,0.0043551824,-0.08387947,0.019607354,0.029839603,-0.048232,0.039573397,-0.02866766,0.03627285,-0.13618876,-0.016506158,0.057850286,0.038106166,-0.02414894,0.0046414034,-0.020172302,0.037283007,0.021643277,-0.08283886,-0.0881942,-0.07494654,-0.021006001,-0.06448017,-0.0134260915,0.03476478,-0.015215873,-0.05939942,-0.17240855,-0.033152204,-0.05222302,-0.055495027,0.0058853514,-0.028414087,0.01359854,0.10891383,-0.08132825,-0.022171963,0.059741803,0.0011524862,-0.027965754,0.05687594,-0.056593057,-0.05513975,0.085510895,0.020856267,0.072784945,0.03050477,-0.055058707,0.051904134,-0.030725347,-0.038721133,0.033795092,-0.042616215,-0.047974188,0.034741808,0.08731429,0.031142557 +2.3.1.103,"The plant enzyme, characterized from Brassicaceae, is involved in secondary metabolism.",384,1.0,-0.11539353,-0.025162512,-0.052772384,0.016751245,0.037271187,0.09111434,-0.090413965,0.06140217,-0.0063568,-0.027271021,0.041047517,-0.022609431,-0.046022154,-0.06989204,-0.06630915,0.009703787,-0.06787357,0.07171676,-0.019438257,-0.08769376,0.02232481,0.02119358,-0.0009489844,-0.009393136,0.09714836,0.017765949,-0.03841665,-0.00467322,-0.03979847,-0.030498095,-0.045043226,0.044648852,0.03407356,0.002791592,-0.002188975,0.07144915,-0.021693435,-0.05824434,-0.01586204,-0.0053290906,0.022321247,-0.007892637,-0.06481525,0.00078129646,-0.0769526,-0.032985,0.0009805475,0.01490371,-0.001792596,-0.017994916,-0.030311638,0.0030606566,-0.028319247,0.0591825,0.032184564,0.040820155,0.06431511,0.029142495,-0.028563842,-0.025847832,-0.0047279377,-0.040790297,-0.04074744,0.011909482,0.024928756,0.003840429,-0.021540305,-0.059502035,0.011095196,-0.078918375,0.023527186,-0.08580803,-0.08410842,0.052202243,-0.037721943,0.024579532,-0.032224484,0.031192409,0.036779255,0.006248852,0.0068820976,0.04229395,-0.032121416,0.010964813,-0.021464394,-0.006878299,-0.03476695,0.06494692,-0.028494906,0.031718384,0.02533344,-0.0031967664,-0.028343534,-0.048455667,-0.06474437,0.060928263,0.058666643,-0.07806476,0.05083774,-0.0666341,0.004437863,0.028144741,0.031499203,-0.09066008,0.0019660846,0.027090516,-0.06272883,-0.008762594,0.016506674,-0.029776197,0.068377264,0.09133232,0.0062030866,0.04123646,0.024181103,0.06255123,0.039729208,-0.066423014,-0.036282826,0.046979103,-0.022326924,-0.05810476,0.0040343176,0.025448838,-0.028775034,-0.004170771,-0.10516211,-4.416582e-33,0.03659579,-0.029151602,-0.02815215,-0.05683399,-0.0044893725,-0.02453058,-0.042740904,-0.016817868,-0.050598115,-0.056987252,-0.07669789,-0.043529212,-0.019589422,0.007651837,-0.016257197,0.015126065,0.023739494,0.04418888,0.14180057,-0.021683693,0.021385228,0.037351467,-0.06203369,-0.012643371,0.04553028,0.08877433,0.021054095,-0.025585042,0.0056817452,-0.026602698,0.013178298,-0.106524065,-0.01479808,0.026773747,0.053837027,-0.055210967,0.009390465,-0.040088046,-0.031641915,0.08199822,0.008270085,0.06523208,0.06991414,0.013095094,0.037398312,-0.0060483315,-0.054861136,0.056325093,0.06322262,0.056788858,0.040573712,-0.0192289,0.16243991,0.018180948,0.043750346,0.0815577,-0.022909129,0.008479097,0.03518373,0.028276902,0.018062437,0.050359506,-0.037063926,0.09253131,0.0677539,0.0065051937,-0.17376773,-0.027956119,-0.012431631,0.15400457,-0.04778312,-0.082413904,0.03954769,0.003946021,0.09946897,-0.009164456,0.010475091,-0.019597284,-0.007897368,0.016885497,-0.005067452,-0.019825544,0.038525738,0.028292451,-0.08801919,-0.054093715,-0.079502285,-0.07233531,-0.07359061,-0.010027122,0.09185458,-0.026770081,-0.053457282,0.04172656,0.012473818,2.4656218e-33,0.097870864,-0.03997936,0.05857449,-0.07229868,-0.024323462,0.064940475,-0.037129384,-0.06931331,0.02615656,0.04875352,0.036495823,0.013416447,-0.012627181,-0.014802803,0.011391205,0.023395501,0.075834095,0.10640483,-0.03484053,-0.006635004,-0.054194286,0.054802325,-0.039914727,-0.05504175,0.010014842,-0.02692103,-0.05352029,0.05050345,-0.040836282,0.0027438211,0.060391456,0.04244895,-0.0189363,-0.03769158,0.01677417,0.0041085714,-0.07388729,-0.034551382,0.043252755,0.081783816,0.017157806,0.054832723,0.06977866,0.05725852,0.04653658,-0.08486778,-0.03061854,0.00091845816,-0.066591725,-0.021496437,0.032654542,0.030151173,0.024111236,0.065891504,0.056091465,0.012155155,0.06272383,0.004067181,-0.003558807,-0.0408108,0.06636757,-0.11287256,0.03428231,0.025100205,-0.015056426,0.08804055,-0.01639221,0.0111102685,-0.01559872,0.08519459,0.014174209,-0.014978287,0.05603329,0.079289764,-0.012324649,-0.00063701154,-0.057114754,-0.00085664366,-0.032577522,-0.009034223,-0.04538318,-0.006151951,-0.012648382,-0.13889821,-0.040542535,-0.08776432,-0.04747386,0.061403025,0.052236326,0.04467327,-0.052696083,-0.044238593,-0.10046615,0.017114542,0.09879884,-2.1288072e-08,-0.036821976,-0.039553158,0.009315449,-0.00036162045,-0.0030009584,-0.022676783,0.034673396,-7.765708e-05,0.040508814,-0.046636898,-0.028482456,0.07266829,0.011774226,-0.00841385,0.067701675,0.04905597,0.090137586,-0.028107684,-0.029152608,0.0444615,-0.047860753,0.020513259,-0.1092854,0.010417417,-0.049512427,-0.04436309,0.049208123,0.08434553,0.040836487,0.026235504,0.05437234,0.048973076,-0.02055161,-0.08562573,-0.107255675,0.006141421,0.017622558,-0.0032938076,-0.0021597974,0.0143553885,-0.026817897,-0.044260163,-0.06817127,0.04013817,0.0024311785,-0.0012872098,0.021483677,0.06285045,0.07176525,-0.010276735,0.02547247,-0.051108643,-0.026083453,-0.07328543,-0.023753857,0.04800726,0.07359268,0.017770905,-0.052869555,-0.07886372,-0.00829607,0.055025063,0.21834154,-0.02506798 +2.3.1.104,Not identical with EC 2.3.1.121 1-alkenylglycerophosphoethanolamine O-acyltransferase.,384,0.9999999,-0.054506514,-0.009040874,-0.080659285,-0.01930669,0.023633484,-0.042892218,-0.04572241,0.07382659,0.098766506,-0.08980072,0.080895424,-0.08304959,-0.07551947,-0.055238247,-0.04434824,-0.0033580516,-0.04648713,-0.080759324,-0.019619284,0.004469441,0.02179681,0.044703227,0.06221494,0.027608592,0.03870687,-0.026638834,-0.03353492,0.032547,0.01727401,-0.06839872,0.06340613,-0.063095234,0.004915756,-0.030946342,0.10921516,-0.0036592542,0.018117437,-0.04128539,-0.038437873,0.08174922,0.053217743,-0.031284336,-0.042950705,0.043028023,0.008501337,-0.037976116,-0.06339822,0.038904794,-0.030302163,0.01764932,0.03909656,-0.059554234,-0.0701608,0.04523404,0.038263403,0.04597974,-0.11638543,0.025962524,-0.039203316,0.051659044,-0.0006152426,0.057847105,0.044949926,0.007188141,-0.021908013,-0.03198923,0.106328025,-0.18718125,0.06861767,-0.010476475,-0.085899964,-0.062006313,0.06074665,0.035542674,0.04906353,0.05779727,-0.029472537,-0.0032771062,-0.0018719569,-0.056398097,0.0061951047,-0.06778841,-0.037885018,0.010568424,-0.023544535,-0.06420399,0.014057758,-0.019825686,-0.032920595,0.01998768,-0.015420332,-0.056292012,0.07982369,0.0008688047,0.0015650768,0.013522885,0.08368599,0.07458727,0.042264506,0.025951669,-0.022281216,0.093384415,-0.042727403,-0.085950635,-0.01574615,0.018022757,-0.0019903607,0.03724996,0.01632361,-0.03921093,0.034155812,-0.07308861,0.06467453,-0.0018984546,-0.031087147,0.08305428,-0.08339424,-0.032845985,0.059204254,0.049054496,0.000505718,-0.07662497,0.024579085,0.09845072,-0.05095792,0.090624385,-0.05667733,3.462141e-33,0.046852425,0.053203385,0.029776804,-0.04324812,-0.030133752,-0.0056293136,-0.11220005,0.0356428,-0.05392926,-0.028847395,-0.0466598,-0.03773143,0.057118498,0.039148472,0.023346694,-0.04916266,-0.030165339,0.022735022,0.045935113,-0.011764692,0.031577706,-0.005746575,-0.000121848934,0.010774997,0.054757774,0.050924387,-0.013204222,0.015451727,0.042078987,0.004523876,-0.0036837868,-0.07831304,-0.03132906,-0.016638495,-0.017214453,0.007812316,0.036644217,-0.0628288,-0.01461134,0.008494322,0.008343898,0.06427952,0.052828167,-0.07301682,0.089295104,-0.032113764,-0.0843103,0.029305428,0.09365175,0.027397353,-0.06666331,-0.036261875,0.12498584,0.06631724,-0.008264035,-0.060402825,-0.08399797,0.043843336,0.031391498,-0.0010314523,0.017898303,0.15369621,-0.027655777,-0.056240052,-0.07264992,0.040133238,-0.05577218,0.0021750515,-0.08206629,-0.0068944725,0.009357793,0.028278973,0.0478419,0.0019992832,0.08941308,-0.042956334,-0.08179005,0.02953874,-0.03960832,0.012647043,-0.036574587,0.01820535,0.041455373,-0.05381856,-0.09096981,0.0075469967,0.017813252,0.024609683,0.023396952,0.08519361,-0.006338032,0.03489989,-0.028024761,0.035507686,-0.008933107,-3.155608e-33,0.0069126724,-0.010414116,-0.038476977,-0.08504954,-0.010800094,0.04286802,-0.0049002804,0.06514925,0.054114934,-0.040780883,0.11019079,0.0065517994,0.014342578,-0.121558,0.07165044,-0.038102552,-0.05868187,0.05170062,0.07055109,0.07195229,0.04895923,-0.029139569,-0.0768164,0.07808174,0.067981765,0.03278761,0.016044164,0.02149376,0.002712084,-0.03576345,-0.030090356,0.057865243,-0.048236012,-0.0025989371,-0.09571904,-0.0040527526,-0.023074625,0.008226987,-0.052545182,0.012490275,-0.016674008,0.032096427,0.0018756428,0.02248702,0.06250642,0.14739801,0.020665303,0.004687946,-0.00024466362,-0.03786094,-0.005483907,-0.016383307,-0.033542883,0.023851719,0.0365277,0.097136125,0.006851108,0.04674144,-0.037995767,-0.044564497,0.017134447,-0.0036584348,0.038438063,0.0365838,0.039351325,0.06042919,-0.026853787,0.03588655,0.0027935933,0.041972466,0.009536127,-0.02807523,-0.08061351,-0.0054992503,0.017395314,-0.060434703,-0.026866976,0.004694857,-0.004649776,-0.092436224,0.027778428,-0.026817031,0.060666468,-0.0023363056,-0.0063561094,0.06423905,0.0052204286,0.0339446,-0.049004536,0.09511503,-0.031561293,0.018566037,-0.13602929,-0.0027539528,0.03130872,-2.8314082e-08,0.0965449,-0.043964572,0.0150374845,0.008393316,0.014696429,-0.0017574653,0.027797678,0.039604764,0.0028999366,-0.040501446,-0.03833015,0.035817422,0.048087817,-0.047099452,0.016283695,-0.024661493,-0.012280315,0.06544489,0.0092561245,0.019503498,-0.06288209,-0.00094596396,0.011103637,0.003110561,-0.021419864,-0.024247436,0.029056601,0.04640546,-0.02140251,-0.050379895,0.012679981,0.034422483,-0.04201306,-0.03481697,0.017648082,0.0040366417,-0.04740272,-0.0012949858,-0.06651108,0.06455121,-0.031042298,-0.0042427387,-0.05091667,0.006589664,0.1391784,-0.052437384,0.050463498,-0.017056752,0.011910994,-0.077943414,0.01786942,-0.0540799,-0.037317213,-0.07381054,-0.06865246,-0.090662636,-0.08278737,-0.06492821,-0.008565514,-0.019229174,0.057080016,-0.050252326,0.15224347,0.011775221 +2.3.1.105,Involved in the biosynthesis of thrombocyte activating factor in animal tissues.,384,1.0,-0.066621244,-0.07414653,-0.05116546,0.020231308,-0.0060660774,0.057510775,0.027653381,0.12846704,0.035950005,0.0999558,-0.029107295,-0.011711416,-0.032007482,0.02053172,0.030036394,0.09675544,0.0073058815,0.0116788875,-0.008799316,-0.10785077,0.018693848,-0.0046755397,-0.020509448,-0.054735497,0.023618896,-0.02819348,-0.069522485,-0.0813334,0.025744436,0.022404417,-0.04064346,0.040343937,0.043552358,-0.072594434,0.013140359,0.063425906,-0.03989439,-0.054934792,-0.0037018443,0.009277673,0.13384306,-0.07085289,-0.024431057,-0.04980867,0.040366743,0.029709596,0.034574814,0.10548988,0.009832888,0.06010029,-0.06418548,0.0051437365,-0.030724827,0.0012639677,-0.062767476,0.013212475,-0.035934813,-0.0033880346,0.027911035,-0.016785698,-0.08354744,0.026911585,0.00252715,0.059250142,0.058235373,-0.052920043,0.020845082,0.015278563,-0.071944565,-0.0045896834,0.024216281,-0.043547686,0.015813593,-0.0013436857,-0.0027154319,0.003651141,-0.009069266,0.026937837,-0.015056952,-0.00081359537,0.04550449,0.0028362563,0.07789142,0.074989215,0.017040528,0.019212304,-0.005725581,-0.015616132,-0.030235609,0.054655455,0.042232316,-0.057599112,0.024092725,-0.016219968,-0.002121798,0.007589603,0.0048710895,-0.024324179,0.057884865,-0.0017737759,-0.05221194,0.014609686,-0.012431643,-0.05164314,0.033205103,-0.005788715,-0.05458558,0.108915046,0.024351945,0.06385615,0.023700342,-0.0564308,0.02107081,0.028284369,0.04090444,0.04311868,0.024088964,-0.048024595,-0.008984265,-0.053851455,0.063032925,0.057661057,0.027796632,0.02903204,-0.08091857,-0.0065226615,0.01589634,-5.6984954e-34,0.10870659,0.015465142,0.005729155,-0.09065171,0.005134473,0.026340323,-0.075052924,0.013749877,-0.0072479774,0.10886868,0.018707618,-0.08966293,0.036327463,0.0033200718,0.0006604235,0.012068082,-0.036912456,-0.06448669,0.13052239,-0.017135965,-0.040137894,0.028380834,-0.039928492,0.048002105,-0.11841129,-1.8779781e-05,-0.045055635,0.07746543,-0.038848296,0.006029291,-0.06574683,-0.11913543,0.036166284,-0.04810732,0.005976897,-0.100387946,-0.03272407,-0.09206572,0.027512714,0.03330963,0.06837294,-0.064493,-0.043783497,-0.065051086,0.037761584,-0.0783979,-0.04405853,0.04414348,-0.04045455,0.032119464,0.040658087,0.023447944,0.19286725,-0.05406184,-0.031354763,0.029360084,-0.0012244318,0.015390574,-0.025299093,0.056836065,-0.10367211,-0.0399907,0.0143921,0.035567295,-1.3730167e-05,-0.109970085,-0.01981333,-0.036435183,-0.12842876,-0.003801942,0.093669064,-0.03150966,0.03416049,-0.06256372,0.04448712,0.017943062,-0.020564305,0.085124485,-0.057088863,-0.043561563,-0.0073043657,0.026371364,-0.064733885,0.022481438,0.00917812,-0.008832919,0.06126999,-0.012122037,-0.024198754,-0.06854207,0.033313844,-0.07681415,-0.05630197,0.012848793,0.08154152,-1.0822617e-33,0.0018014408,0.016272163,0.041205153,-0.011368057,0.019810816,0.007236354,0.027908038,-0.025074784,0.023279391,0.06467657,-0.011643637,0.0016255883,-0.056835495,-0.026453704,0.0021077537,0.021914782,-0.009306352,0.048312414,-0.0672626,-0.038472272,-0.005589304,-0.029465076,0.029973231,0.07609691,0.029833715,0.053811226,-0.082687,0.026464747,0.006889862,0.08007911,-0.07670637,0.0264681,-0.046593346,-0.07971319,0.045468207,0.05853094,0.037288416,0.03263621,0.0018870872,-0.05557367,0.018501673,0.03825807,0.022668378,-0.0018725184,0.06201409,0.1110337,0.003166519,-0.0050215977,-0.030614652,-0.011869868,-0.04562125,0.033495247,0.10092526,0.053847224,-0.03787569,0.06475038,0.08250518,0.022179872,0.027831485,-0.04502345,0.04033736,-0.057989348,0.075229526,-0.079081476,0.0375038,-0.013238309,0.0050676363,0.034735724,0.016125249,0.01720762,-0.009450102,0.050310414,-0.035818126,0.005387812,-0.052832942,0.04485386,0.021172106,-0.06891899,-0.041424908,-0.016726134,0.015400717,-0.019721335,-0.025204187,-0.093434796,-0.046441197,0.0056431727,-0.022053361,0.08487737,0.03636458,0.009103486,-0.08542621,-0.021680428,-0.06799029,0.053069815,-0.014210227,-2.339451e-08,-0.02605586,-0.07257588,-0.06393409,-0.065726064,0.045622624,-0.024970565,-0.10478803,0.030513097,0.014492961,-0.017011441,0.008490985,0.006587807,0.009565423,0.03066939,0.080322415,0.053779177,0.08259646,-0.06727853,-0.020131387,-0.09053275,0.031186728,-0.043123145,0.04632766,0.03334565,0.0047530923,-0.11249764,0.004552457,0.011996694,-0.011466677,0.028364232,0.011034563,0.027110117,-0.0369693,-0.028237348,0.014699407,0.020038735,0.028000893,-0.106627926,-0.035679948,-0.04834549,-0.02676438,0.04017539,-0.082419455,0.04449498,-0.0068325335,-0.0027655242,0.040991697,0.02948814,-0.020070298,-0.08943035,-0.09376338,-0.029518576,-0.07577606,-0.061277516,-0.07442019,0.015013008,0.032925967,-0.014777275,0.084215134,0.0032421963,0.004600246,0.07905366,0.17802973,-0.080590956 +2.3.1.106,"4-Coumaroyl-CoA (4-hydroxycinnamoyl-CoA), caffeoyl-CoA (3,4-dihydroxycinnamoyl-CoA) and feruloyl-CoA (4-hydroxy-3-methoxycinnamoyl-CoA) can also act as donors for the enzyme from the mung bean (Vigna radiata).",384,0.99999994,-0.07505051,-0.0026436292,-0.0795324,-0.019783787,0.08939264,0.0194324,-0.071608394,0.06201805,0.027256818,-0.058847733,0.071231455,-0.13824181,-0.0019253216,-0.010207901,-0.023751227,-0.0061018993,-0.019763501,0.043102868,0.0030755089,-0.061110232,0.03322385,0.015099106,-0.0028238702,0.010897263,0.030661507,0.04075985,0.00248958,-0.044214223,0.04460644,-0.0847703,-0.03273015,0.03088665,-0.0022470702,0.011173994,-0.04634576,0.06782436,0.004072549,-0.10750665,0.07259701,0.06466846,0.006860575,-0.05483188,0.017061101,0.005959392,-0.07291772,-0.096063465,0.013600959,-0.014601618,0.086979896,0.010635349,-0.039045166,-0.024430657,-0.08378909,0.073054135,0.018206606,-0.004099312,-0.030877229,-0.04502943,0.006508442,0.12375735,0.046507515,-0.0031146333,-0.008147542,0.03994836,-0.0064570685,-0.02679595,-0.024762742,0.0095744645,0.06494561,-0.071728475,-0.030909205,-0.054569475,0.04248792,-0.036734935,-0.03501545,0.08869118,0.00566402,0.039222915,0.048435066,-0.027914006,-0.065694466,0.040811207,0.06614193,0.046230588,0.03906013,0.0919642,-0.022632798,-0.0011996209,0.030957965,0.04674765,0.030552402,0.04669172,-0.0057156403,0.02411107,-0.1215292,0.076775864,0.023103312,-0.054485705,-0.026835801,0.02032291,-0.06370188,0.05423799,0.017492086,-0.05948132,-0.06370073,-0.049338985,-0.038516935,0.012894823,0.040659145,-0.0063524367,0.0018150073,-0.0073862094,-0.0069943597,0.051669337,0.0059857024,0.07247834,-0.04968563,-0.059321143,-0.012355988,-0.02206292,0.04567821,-0.04427884,0.012897337,-0.040714357,-0.040231146,-0.008464875,-0.073274545,4.214124e-33,0.057543784,0.04431187,0.014565252,0.055850625,-0.00929752,-0.019046228,-0.07527977,0.03405709,-0.11459365,-0.028971972,-0.083576344,0.020126635,0.0072039594,0.0374439,-0.035519104,-0.098808095,-0.055059485,-0.03444176,0.021591425,0.022823352,0.078090034,0.06268464,-0.008939944,0.06128488,-0.02006361,0.052098304,-0.037626404,0.022890309,0.07517455,0.03658838,-0.016567888,-0.047809426,0.0050572623,-0.016619958,-0.045549836,-0.059579182,-0.09210542,-0.05995773,-0.039689768,0.14804746,0.041583054,-0.02057707,-0.024186825,-0.009225411,0.091265075,-0.034035888,-0.025648609,0.07514111,-0.008787646,0.066931225,0.010916896,-0.020756586,0.08867835,-0.012842119,-0.05759555,0.040592667,-0.011286104,0.0063102217,-0.015157354,-0.01041605,0.0062069143,0.044703413,-0.015158317,0.012862702,0.009394184,0.020868585,-0.0671607,-0.06543202,-0.00025588615,0.063790105,0.00065370713,-0.00037958994,-0.019548364,0.030464338,0.091979645,-0.090766944,-0.00943043,0.04827183,0.014657492,0.0149859935,0.0043914104,0.04851323,0.08271117,-0.01266708,-0.04176516,0.019259663,-0.0064059077,-0.0536673,-0.0029968424,0.00368779,0.023683941,-0.017837722,0.019709997,-0.05244406,-0.019163923,-2.8328492e-33,0.11111529,-0.10342895,0.064780615,-0.04827399,-0.052760623,0.077957675,0.06664004,-0.11441817,0.07959056,0.005469072,0.07542153,0.008313372,0.02234584,-0.096475504,0.040131148,0.055849604,0.033660464,-0.0035059121,-0.05529108,-0.006835253,-0.029503666,0.08456214,0.058608416,-0.04797101,0.05482998,2.8034183e-05,0.0654638,-0.027718717,0.0040001,0.033725873,-0.022951411,-0.066181414,-0.009499177,-0.002460441,-0.044981048,-0.00032221887,0.004105655,0.031674977,0.010111565,-0.012354762,-0.07249623,0.02095712,0.031029629,0.035707444,-0.017776903,0.028098902,-0.07554985,-0.014339202,-0.044153243,0.016264025,0.013437373,-0.030730648,-0.07528978,0.011941784,-0.041115385,0.013832924,-0.0067211594,-0.0126337,0.030533621,-0.051115617,-0.041817695,-0.041032366,0.05798963,0.042542107,0.08737842,0.08258366,0.031211713,0.05573127,0.030996183,-0.033807985,0.10996152,0.015934275,0.019664362,0.007567783,0.022255242,0.021786382,-0.058810446,-0.030666703,-0.075376794,-0.044098258,-0.027102567,-0.036750667,-0.020926133,-0.045866635,-0.073654436,-0.08047145,0.0706727,0.085842945,0.110243656,0.06620798,-0.055215932,0.046548557,0.023156827,0.05229885,0.15739371,-4.3799215e-08,-0.020738507,-0.072934724,-0.044795327,0.00017584584,0.07023389,0.040348217,-0.083870545,-0.06204224,0.07243145,0.021015843,-0.034844182,0.090073764,0.01241788,0.02826259,-0.013944115,-0.029298788,0.021702938,0.05373086,-0.008339258,0.010832824,-0.09107425,0.014281445,0.0015340102,0.044003226,0.040523488,-0.06311206,0.011225361,-0.0057173115,0.078469016,0.0075664273,-0.014910139,0.04792285,0.0033197857,-0.06963133,-0.10190301,0.031494565,-0.002024584,-0.010171907,-0.0628582,0.08052649,0.070479155,-0.069784425,-0.019806422,-0.012628436,-0.031228596,0.0041697635,-0.032716516,0.036973964,0.024414264,-0.0108269295,0.022347612,0.042728167,-0.01757592,-0.024469657,-0.12090909,-0.021428967,0.017677179,-0.056328747,0.019269569,-0.11777003,-0.053326212,-0.0020690775,0.20439233,-0.0017938344 +2.3.1.107,"Catalyses the final step in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus.",384,0.99999994,-0.05462489,0.012908398,-0.11491584,-0.06272763,-0.022058994,0.06489177,-0.10590841,0.03068454,0.023448968,0.011782935,-0.0084306225,-0.026394706,-0.02717591,-0.062246084,-0.066814646,0.07564861,-0.09295914,0.061130796,-0.020633234,0.0058651515,0.05452303,0.026972175,-0.010160659,-0.013564238,0.035044953,0.059237994,-0.0034716267,-0.007714913,-0.047577918,-0.070320375,0.011950593,0.004686982,-0.04243854,-0.09782444,0.026341204,0.036839623,-0.03487018,-5.1574112e-05,0.10865423,0.06275779,0.008504579,-0.02452846,-0.07178871,-0.031209854,0.000100826335,-0.006152742,0.012608203,0.01909791,0.06659773,-0.07843219,-0.07895697,0.0073945574,-0.0833672,-0.053456392,-0.035773955,-0.050418843,0.039284162,-0.0046570804,-0.012380878,-0.026688231,0.009435761,-0.0066023082,0.013868853,-0.00036865348,-0.026113328,-0.0647894,0.01854555,0.0062629264,0.043881357,-0.07249248,-0.029942704,-0.04140224,-0.0062947143,-0.045407765,-0.070195325,0.058380056,0.0072630527,0.05027537,0.006913321,-0.015691286,-0.050954014,0.010021149,0.00033656828,0.088085406,0.055290792,0.07214204,0.04802655,0.024273017,0.07750421,0.09342795,0.019943632,-0.008930194,0.04526787,0.008128905,-0.05880764,0.0228166,0.05405477,-0.031770065,0.020500617,-0.038733948,0.030012446,-0.01481894,-0.02033146,-0.063775726,-0.05426021,0.07597868,-0.012035255,0.10007827,0.05154479,-0.04503917,-0.003595304,-0.017049924,0.014195411,-0.0045091924,0.0019825413,0.108342536,0.04611148,-0.022877285,-0.012714308,-0.023056557,-0.012835871,-0.011901298,0.004989249,0.030638708,-0.040609956,-0.016570527,-0.054625567,1.7231215e-33,0.054971788,0.085159674,0.003105986,-0.062406067,0.04346286,-0.00309497,-0.18112905,0.03473652,-0.04248349,-0.020665325,-0.09619006,-0.12647784,-0.023376074,-0.0075840037,-0.052598275,0.001810398,-0.004012164,-0.033437144,-0.032667965,-0.009717945,-0.01723423,0.010488444,0.009921919,0.0036906064,-0.019532789,0.0655633,0.009758867,-0.049284175,-0.05343532,0.007327699,0.020670092,-0.17914248,-0.014224137,0.016462011,-0.018368796,-0.018847708,-0.011454639,-0.08222174,0.022790153,0.07538007,-0.0033112594,0.02710518,0.019700238,0.004682415,0.021438412,-0.040071275,0.028141623,0.17860642,0.028257156,0.044188894,-0.042222045,0.02721706,0.16739592,0.033756536,-0.11607865,0.020276679,-0.03174336,-0.011412323,0.05483772,0.04957315,0.03520578,0.046925835,0.025483271,0.016933506,0.0024398034,-0.0019083134,-0.02775678,0.02930794,0.09128721,0.007265833,-0.06708733,0.009655735,0.017448645,-0.019552473,0.08990644,-0.05363678,-0.011115389,-0.028312676,0.055550463,0.02155334,-0.030920938,0.032280963,-0.06106776,-0.026274346,0.005114346,0.06472866,0.026963137,-0.016928,-0.04101553,0.09315124,0.014949979,-0.05648969,-0.022191474,-0.018812403,0.047052413,-2.0821148e-33,0.035461735,-0.059837338,0.005456492,-0.061901957,-0.029234549,0.03248058,-0.06350071,0.009798893,-0.019526733,-0.041195836,-0.061187327,0.0009039443,0.0867095,-0.03208504,-0.03865221,0.010705851,0.04785166,0.107657336,0.04222353,-0.06850011,0.001193648,0.028248984,-0.02426901,0.021481598,0.035905637,-0.020482749,0.015378504,-0.012561043,0.028839136,0.08561924,0.06068415,0.027558884,-0.073598705,-0.02756555,0.0012637965,0.10693758,-0.038678985,0.08173909,0.07756524,0.06863745,0.02947051,-0.011839037,-0.05078157,0.04109977,0.0014836089,0.023808805,-0.06482148,0.07212608,-0.042116515,-0.03347799,0.10539988,0.037194848,0.055816855,0.0094003985,0.038785208,0.027050495,0.035668895,0.0017737173,-0.03214738,-0.058962367,-0.0648607,-0.045075983,0.01636717,-0.019192215,0.009147923,0.0764799,0.009638127,0.03876409,0.06928871,-0.05791016,0.06476489,-0.017769283,-0.03622184,0.066018276,0.040935602,0.017926449,-0.03640547,-0.078442596,0.0054524755,-0.012240488,-0.015898705,-0.003293207,0.032728665,-0.11642163,-0.069668636,0.022161238,0.035498835,0.076683275,-0.037851922,0.031969447,0.015017892,0.043744016,-0.06085593,0.040559053,0.04460074,-2.5679164e-08,0.08544881,-0.03176373,0.081084386,0.03644629,-0.0025120212,0.036052667,0.04414457,0.031978153,0.010837894,-0.024478735,0.030877143,0.06386293,0.05544193,0.0024761101,0.06214806,0.06553892,0.080544084,0.0031755338,-0.02696122,0.0082366,-0.07506188,0.03868766,-0.067617014,-0.043614183,-0.009796416,-0.09773077,0.011902681,-0.025239388,0.0028277757,-0.040952794,0.06155042,0.01419669,-0.04422426,-0.13647413,-0.047209155,0.006980541,-0.0030963838,-0.07819258,0.050951187,-0.062632054,-0.013627186,-0.046803936,0.0060007675,-0.0048799776,-0.06305283,-0.010521053,0.0023485867,0.0371892,-0.040836718,-0.048901394,0.049045425,0.015397323,0.059832934,-0.09937154,-0.12310065,0.04667883,0.037333786,-0.056985777,0.009765656,-0.0675222,-0.009401577,0.03770344,0.13926943,-0.10057087 +2.3.1.108,The enzyme is conserved from protists to mammals and is present in flowering plants. In most organisms it acetylates L-lysine at position 40 of alpha-tubulin.,384,0.99999994,-0.03394777,-0.09916541,-0.0704679,-0.05068569,0.10334566,0.13035786,-0.040480923,0.051614977,-0.022674268,0.08929415,0.05958432,0.026903436,-0.05578205,0.007880542,-0.025267607,0.08011746,-0.10873559,-0.009004067,-0.04984633,-0.025829602,0.05565464,0.051183015,-0.041733816,0.044396415,0.040326763,-0.08633629,0.0067649772,-0.033924684,-0.010751862,-0.081923045,-0.074147396,-0.04850385,0.016928412,-0.07450928,0.037352707,0.0026970543,-0.10259432,-0.114314765,0.110377595,0.02660526,0.05212811,-0.020327665,-0.08961125,-0.080188975,-0.051495273,0.046762615,0.018791724,-0.015073913,0.032667316,0.05885936,-0.020698585,-0.03584169,-0.049564227,0.021030053,-0.14364499,-0.039484907,0.005326439,0.079709105,0.022121893,0.048557546,-0.00960905,0.05832167,0.01746825,0.0029352147,0.03645011,-0.09172896,-0.09073855,-0.0067873313,0.039063405,-0.031692825,0.015871312,-0.07783744,-0.0065111774,0.079668656,0.02070594,-0.012704086,-0.011232014,0.024800774,-0.0053984774,0.029598298,0.035622887,-0.020368215,-0.035050757,0.08051453,0.033760495,-0.02285504,-0.010795259,0.08296039,0.02571641,-0.06163679,0.040870473,-0.05935923,-0.05646978,-0.013361737,-0.0813153,-0.015222205,0.02281268,-0.06571846,0.0023573628,-0.0130959125,-0.011222755,-0.0036658328,-0.014158804,-0.028050842,-0.048121434,0.0070372275,-0.0069099963,-0.007972512,0.012655235,-0.017814748,0.03603433,0.016320178,0.042858884,0.05795068,-0.028916504,0.013779586,-0.016619163,-0.066698276,0.013534271,-0.03268432,0.06824356,-0.0011090828,0.11592094,0.087357715,-0.037207987,0.115371965,-0.10274821,-5.9399787e-34,0.021279437,-0.034055736,0.02209677,-0.017389806,0.018424977,-0.002800805,-0.038378686,-0.03275681,0.022424832,-0.07729382,-0.08902324,-0.031482216,0.071748674,-0.021510184,-0.0762505,-0.0029894973,0.007976821,-0.033849377,0.04432276,0.072818354,0.023295844,0.05560875,-0.037971888,0.055497304,0.040588234,0.000807004,0.030295985,0.0018124363,-0.034832016,0.012185745,-0.022219492,-0.10796386,-0.06873623,0.06028753,0.081329845,-0.0317265,0.011065417,-0.09091275,0.047047395,-0.0024251319,0.02724312,0.0437444,0.028398091,-0.030255474,0.043482073,-0.020392587,-0.051290803,0.08477867,-0.019145954,0.0002138638,0.10219942,-0.026125455,0.075097,-0.009811001,-0.045789994,0.0023687042,-0.051342808,0.02770406,0.0075113294,0.08287455,0.071628295,0.059200197,-7.2602576e-05,0.031272396,0.035486776,0.0730649,-0.104148366,-0.0104980245,0.025623135,0.02389678,-0.121715985,-0.06223454,0.07235206,-0.004443601,0.00781727,-0.051534448,-0.026319211,0.04388369,-0.014583668,0.0029017748,0.014124539,-0.004484116,-0.042378046,0.047557373,-0.04193633,-0.076687746,0.041425843,-0.009501207,-0.008727526,0.014578433,0.10505459,-0.0050729825,0.0024923903,0.09467168,-0.029675063,-1.3797249e-33,0.019307578,-0.090653926,0.05830345,-0.01152118,-0.045837946,0.051612902,0.059419606,-0.032368504,0.016892897,-0.01739844,0.035463717,0.05751282,-0.0013078131,-0.031826187,0.082116246,0.015804129,-0.017118033,0.037290554,-0.027731448,-0.039388828,-0.04853812,0.07535574,0.04679663,-0.04586228,0.035696566,-0.051481705,-0.040803522,0.06193776,0.055894263,0.0027059477,-0.006097503,-0.016210059,-0.02192509,-0.06431569,-0.0152207725,0.0048865783,-0.010029545,-0.049537197,0.045449283,0.021609932,0.0017979677,-0.00020971864,0.033862505,0.037194226,0.04928001,0.029780254,-0.05932892,-0.0107395975,-0.06105905,-0.0063513936,0.024108805,-0.068611935,0.026502805,-0.049469378,-0.027594179,-0.005285379,-0.01632495,0.05718807,-0.07566245,0.02957415,0.00648213,-0.037108883,-0.02235626,0.07890497,0.01306525,0.034030337,-0.028761743,0.03754755,0.018021397,0.034371067,0.09761634,0.06504451,0.03468518,0.08791171,0.01712541,0.039203987,-0.05072085,-0.064821854,0.001957787,-0.055908628,-0.066062585,0.0318731,-0.022549544,-0.056731522,-0.020999843,-0.066807225,-0.057253305,0.106608786,0.05328671,0.0142920865,-0.03062963,-0.102076426,-0.06511137,0.00416267,0.12709673,-2.6769836e-08,0.0003726395,-0.009439182,0.014052541,0.0022406965,-0.013958628,-0.03871668,0.014783705,-0.007639247,0.06949062,-0.021176621,-0.010484569,0.062824845,0.031266205,-0.028341506,0.031699914,0.029838065,0.081598334,0.09131832,-0.041392054,0.06951265,-0.0371985,-0.018274948,-0.110959604,0.022256343,-0.048478067,-0.07600778,0.010647581,0.06712511,-0.056999344,-0.030677637,0.021218311,0.0064510657,0.025711155,-0.084002174,-0.07309626,0.060247984,-0.021679481,-0.031067993,0.04449702,0.041968033,-0.01673534,-0.023613894,-0.042447414,-0.012182229,-0.0032644544,0.03572777,0.017899862,-0.011203495,0.019033156,0.0055686273,0.00839595,-0.01849426,-0.010157711,-0.089077316,-0.04592725,-0.029802425,-0.035789076,-0.011259984,-0.013826963,-0.07312788,-0.011031314,0.10096405,0.2108908,-0.04547697 +2.3.1.109,"Also acts on L-ornithine. This is the first enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [2,6].",384,1.0,-0.049810287,-0.08064361,-0.07766513,-0.03156218,0.045088377,0.05528289,-0.027395597,-0.0065820087,0.00076690706,0.04254957,0.01628297,-0.035596352,0.011762067,0.028097454,-0.08986656,0.041972864,-0.13637854,-0.05242685,-0.007933304,-0.043132406,0.07282103,0.08839696,-0.060300525,-0.06979923,0.12109058,0.0066571278,-0.002807518,-0.05048607,-0.0038555162,-0.08212101,0.0012147228,-0.10974043,-0.008609379,-0.010736197,0.07762151,0.047373593,-0.08270776,-0.042583767,0.09088526,0.019736238,0.021121116,-0.052001804,-0.096506014,-0.07234568,-0.02456587,-0.0063606715,0.0059261527,-0.010560446,-0.010725788,0.002212516,-0.04700309,-0.028537571,0.0016155313,0.039777108,-0.03702231,0.033535846,-0.120321095,-0.025248837,-0.0045786733,0.036600117,-0.045745134,-0.0058141113,-0.020420758,-0.049522832,0.06477878,-0.013749453,0.0625576,-0.09626553,0.041476395,-0.026576571,-0.039276667,-0.08016907,-0.027526712,0.053442646,-0.011252286,-0.013508831,0.02019443,0.014711011,-0.017866537,-0.080413915,0.056183085,0.061414596,0.07468441,0.06624802,0.00474889,-0.020783653,-0.032404635,0.06046939,0.052616812,0.050842155,0.017544134,-0.047343373,0.013656028,-0.017766055,-0.007441079,0.028890183,0.006905889,0.041434456,0.073503315,-0.05686178,-0.0039070505,0.046979893,-0.05394921,-0.08676525,-0.015742645,0.03292369,0.06462014,0.0672407,0.0041457443,-0.00112947,0.023239018,0.008788738,0.014906901,-0.010114569,-0.025049949,0.098397486,0.061411414,-0.04258102,-0.06842193,0.003940218,-0.03579257,0.05529921,0.10568093,0.11401608,-0.083191425,0.115855046,-0.1169593,5.791766e-33,0.056174345,0.00052445533,0.021408621,-0.008141889,0.025688667,0.020551177,-0.094340466,0.09633962,0.031693224,-0.05125331,-0.05902561,-0.065454006,0.07480292,-0.029293409,-0.017937992,-0.036174722,-0.011783197,-0.032882925,0.019264145,-0.020154215,-0.026162783,0.052485496,-0.052469872,0.054340888,-0.007819166,0.005866967,0.03190598,0.044570424,0.001775818,-0.02956602,0.022312729,-0.11121937,-0.09249577,-0.028704327,0.039238915,-0.03798989,0.017230503,0.034572158,0.0004744705,0.0992026,-0.004191453,0.042953916,-0.053734742,-0.019979194,0.05474822,-0.014357018,-0.0472504,0.12149754,0.03264625,0.0756711,0.044554695,-0.035456646,0.09630585,-0.026904862,-0.06697247,0.02934582,-0.015637305,-0.023895215,0.06561036,0.065055415,0.038339023,0.0033315988,0.009401573,0.023953011,0.00746155,0.04503832,-0.0815571,-0.08008046,0.0055965413,0.06741096,-0.13820575,0.000359624,0.07922333,2.9139455e-05,0.059751473,-0.003509654,-0.08785113,0.06470465,0.0070466455,0.019049522,-0.026564976,-0.0036140492,0.061662752,-0.033377018,0.006464978,-0.04810378,0.021789514,-0.12560049,-0.010040414,0.031087331,0.032740813,-0.051915996,-0.07351568,-0.008391426,0.04407088,-5.324373e-33,0.15482844,-0.06285614,0.03138222,-0.046018302,-0.08945811,0.058835983,0.0066982224,-0.009971972,0.020398052,0.005991601,0.09714059,0.06298673,0.094690874,-0.00037732229,0.051862244,-0.047773823,-0.007889906,0.070545726,0.034452446,0.036903102,-0.0039017652,0.08237057,-0.052608225,0.0139438,0.054737605,0.033203345,0.021075154,0.022874199,0.03051827,0.021086143,-0.02218615,-0.011042834,-0.018532194,-0.032753803,-0.045660783,0.03651687,0.013282802,0.013901426,-0.08767593,-0.025125453,-0.044155847,0.019239368,0.025836334,0.03712178,-0.016208017,0.018503502,-0.06991655,-0.047519125,-0.108232,-0.07147137,0.046152,-0.022582866,0.031079197,-0.012591343,0.0022553003,-0.022902858,0.030451361,0.0045092157,0.0011744844,-0.037629925,0.027703697,-0.018970001,0.01965028,-0.038548984,0.06473638,0.009824141,-0.03127009,0.0316223,0.016029336,-0.036760386,-0.013992079,-0.04533589,0.07075603,0.042711716,-0.03597264,0.002691389,0.02296922,-0.07752438,0.023554243,-0.08742682,-0.021045111,-0.03216674,-0.04133868,-0.047719005,-0.04185079,-0.0035559041,0.06604649,0.12698118,0.011913326,0.05988061,-0.0500169,-0.0030000473,-0.023354655,0.06447649,0.10346823,-5.265236e-08,0.018010685,-0.033558518,-0.019890176,0.049207307,0.04071333,0.060654365,-0.009344916,-0.02547017,0.036792107,-0.03279637,-0.02423259,0.083693,0.01647399,0.025962649,0.01752967,-0.016329447,-0.022404177,0.027198758,0.013984981,0.012068149,-0.09694828,0.0005038721,-0.08551171,0.036731567,0.060933184,-0.118749075,0.056980737,0.040859975,-0.0030579194,-0.07017071,-0.02932765,0.013808016,0.06385458,-0.061283853,-0.036843743,0.005878108,-0.010332702,-0.050057635,0.019174043,0.028648669,-0.0038649822,0.03860638,-0.028321924,-0.011769403,-0.042193867,0.0127680935,-0.007710527,0.019597912,0.01570934,-0.021554332,0.018478299,-0.029133884,0.031501908,-0.0501131,-0.090347305,0.03492744,-0.0636336,-0.06033061,0.029391069,0.007055442,0.038169052,0.05054266,0.1479175,-0.041899577 +2.3.1.110,"Cinnamoyl-CoA, 4-coumaroyl-CoA and sinapoyl-CoA can also act as donors, and some aromatic amines can act as acceptors.",384,0.99999994,-0.09794469,-0.039241306,-0.09620927,-0.065007724,0.072560884,0.037678666,0.010772418,-0.0075982963,0.050986685,-0.027536701,0.07892966,-0.09659439,-0.07725673,0.10840568,0.007576104,0.041217677,-0.020756645,0.00052307785,-0.024684832,0.018650487,-0.069582455,0.056697495,-0.05339106,-0.012544376,-0.045041304,0.06696546,-0.01556803,-0.05354182,0.08052764,-0.06763634,-0.005031261,0.0015691939,-0.062092155,-0.0023259,-0.030154739,0.03738487,-0.07780292,-0.023331517,0.008753607,0.075577445,0.050044198,-0.05870517,0.04601812,-0.058163296,-0.11064608,-0.08760432,0.054026615,0.02894349,0.050736237,-0.029111471,0.009343905,0.02957796,-0.072281405,0.09533974,-0.032440614,0.020004865,-0.078152664,-0.05399127,-0.04928479,0.032030266,0.024466002,0.017224222,-0.041077774,-0.0037252684,0.0022628298,-0.0025663027,0.058328062,-0.0017195396,0.058844462,-0.0630914,0.025717555,-0.05820773,0.017898573,0.0014744874,0.05242277,0.04725022,-0.0119568575,-0.010241458,0.036575068,0.011515288,-0.09261571,0.059036452,0.05581244,0.029502038,0.09589574,0.08963496,-0.08041548,0.030439192,0.02197271,0.035140675,0.017978821,0.036640875,0.02487465,-0.027555952,-0.06405514,0.031085558,0.06975792,-0.015819676,-0.0033481356,0.040153332,-0.047749203,0.05978796,-0.10015,-0.087189496,-0.09363231,-0.06458325,0.05582731,-0.011427437,-0.0078099566,-0.000248651,-0.05378866,-0.032461956,0.067289054,0.00446526,0.012991303,0.024973627,-0.04548337,-0.05235478,0.028493436,-0.026793871,-0.022568883,0.0038948692,0.044890273,0.0067590354,-0.0028097003,0.032568064,-0.059810426,1.284655e-33,0.004010369,0.06539331,0.06390186,0.08904473,-0.036088385,0.0058553386,-0.08415699,0.01792516,-0.04469832,-0.10968808,-0.044147544,0.007369494,0.02412609,0.08880916,-0.016222088,-0.06970307,-0.021109924,-0.019661583,0.09591954,-0.033786338,0.048808105,0.10206136,-0.004199833,0.07672006,0.006384416,0.0038067845,-0.04762818,0.08563213,0.04102947,0.028744146,-0.0029631727,0.021509074,-0.019040896,-0.023791129,-0.009541012,0.013397351,-0.09147598,0.006593308,-0.08182531,0.028656496,0.026134532,-0.021615531,-0.08596576,0.021939509,0.02776219,-0.029903894,-0.056421597,-0.01337323,-0.0735485,-0.0017492898,0.007563799,-0.015052217,0.029607672,-0.018190345,-0.1033931,-0.0074448115,0.026273761,-0.034707278,-0.010057477,-0.06092163,-0.02521344,0.018108314,-0.040439196,0.0044680694,0.0032471647,-0.02876433,-0.0032953147,-0.06871278,0.0015397535,0.011770906,-0.014760142,-0.013931194,-0.022602154,0.08167043,0.07971297,-0.09091299,-0.037381742,0.05890468,0.120854676,0.05126319,-0.00319095,-0.060605668,0.05121606,0.019077457,-0.053960294,-0.068199426,0.04983944,-0.07025344,0.05538187,-0.054982964,0.026901593,-0.062772416,0.038926218,-0.057217807,0.043957267,-3.5369655e-33,0.12367006,-0.10830629,0.027940791,-0.040954374,-0.010181652,0.05778759,0.03477085,-0.13010201,0.11048158,-0.016746687,0.12234141,0.0046353918,0.03845418,-0.0005531563,0.045970857,-0.0122830095,0.0048190947,-0.042927515,0.006435722,-0.030467289,-0.016755033,0.032521497,0.039117165,-0.040719505,0.03483763,0.02807502,-0.008438212,-0.029578231,0.037167884,0.03980565,-0.018288765,-0.025617788,-0.03944299,-0.073958516,-0.05626836,0.047507595,0.0029399197,0.059398007,-0.06994074,-0.058838144,0.007911444,-0.010649657,0.078305915,0.10485243,-0.030680709,-0.027301623,-0.022279652,-0.028485028,-0.05381828,-0.035786115,0.013861756,0.058244225,-0.03400816,-0.025696177,0.046141062,0.06604398,0.034152493,-0.09317062,0.06707919,-0.041082546,-0.09684537,-0.019987939,-0.029157948,0.0027479718,0.048591383,-0.03536131,0.009668132,0.029248185,0.06397839,-0.047090527,0.10730658,-0.04509834,0.08966153,0.012298311,0.005482387,-0.109793276,-0.04702636,-0.004773071,-0.023096196,-0.047157638,-0.076714106,-0.09411682,0.01703727,-0.025158929,-0.03354939,-0.100168295,0.085113145,-0.0065322663,0.0013322824,0.033001192,-0.018742999,0.043946054,0.0905788,0.1176899,0.09139862,-3.4413933e-08,0.0064109075,-0.042529643,-0.015280367,-0.031512104,0.0024031892,0.015228464,-0.057976242,-0.03459519,0.04082105,0.036821477,0.029135052,0.07743852,0.057493314,0.03617692,0.026958069,0.00037040186,-0.058110222,-0.025480118,-0.017864065,-0.10139449,-0.09235557,0.0013250601,0.020534752,-0.001900506,-0.012242484,0.013538689,0.025871769,0.023409577,-0.009307655,0.068196274,-0.017805973,0.028918557,0.0013812471,-0.02362474,0.017077006,0.06281887,0.064736106,-0.06951373,-0.04942358,0.014195891,0.061331153,-0.023279427,-0.0961703,0.0004934769,0.056275405,0.01311423,-0.0019035828,0.041088797,-0.012161988,-0.009771074,-0.004925584,0.01782284,0.011994125,0.027419917,-0.060212906,-0.014522193,-0.0019005745,-0.00027707775,0.08504145,-0.06806881,0.001736153,0.017116,0.1191541,0.021823542 +2.3.1.111,"The enzyme, characterized from mycobacteria, is loaded with a long-chain acyl moiety by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, and elongates it by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8-tetramethyloctacosanoate (C32-mycocerosate). Since the enzyme lacks a thioesterase domain, the product remains bound and requires additional enzyme(s) for removal. Even though the enzyme can accept C6 to C20 substrates in vitro, it prefers to act on C14-C20 substrates in vivo.",384,0.99999994,-0.057528596,-0.0418703,-0.11461481,-0.022129986,-0.024014093,2.7773625e-05,-0.051295638,0.08599248,0.0002401046,-0.0066549815,0.009334814,-0.08556499,-0.024293257,0.02407178,-0.016053684,0.015303823,-0.012365749,-0.036758903,0.023764258,-0.01566453,0.03204282,0.050644904,-0.020902,-0.044456217,0.0305759,-0.0561451,0.04740226,-0.004594861,-0.0169858,-0.05767291,-0.0027996672,-0.06978553,0.05251698,-0.039167568,0.12984496,0.068949014,-0.039701708,-0.05622826,0.07250894,0.02109191,0.09074613,-0.031488247,0.007824386,0.0015245676,0.019079082,0.0037229941,-0.0023972401,0.031721774,0.0023156041,0.034229055,-0.022693668,-0.080373414,-0.08256725,0.06646674,0.01239578,-0.015236832,-0.036903065,0.001421796,-0.023448447,0.07715394,0.08168518,-0.04818488,0.04522408,0.058376696,-0.006777178,-0.10479289,-0.0005172224,-0.030337527,0.06971067,0.01127886,-0.087569945,0.0016118453,0.0016646136,0.08226877,0.011368358,-0.020153975,0.008210728,-0.054567937,0.03554029,0.0002790821,-0.039056443,-0.007350524,0.009061584,-0.011360219,0.02198783,-0.06816799,0.08919369,-0.019499531,-0.012113072,0.1087962,0.09405297,-0.035646923,-0.014659248,-0.06095638,-0.059033547,-0.051657144,0.10153605,-0.00069592753,0.00446524,-0.054349437,0.022320101,-0.039305028,-0.02303302,-0.022107663,-0.06095283,0.02004234,-0.081169285,0.06093602,0.03699068,0.06979956,-0.056928977,0.07776124,0.033568945,-0.030633591,0.0078115524,0.08727219,0.022278247,-0.107287005,-0.021375334,0.038063057,-0.06439458,-0.09618017,0.047617093,0.03416907,-0.05954536,0.020027148,-0.04904694,2.3374193e-33,0.0050240946,0.03064026,-0.012703457,-0.020224672,0.043813173,-0.07117134,-0.07010561,0.029461479,-0.08624151,-0.015603085,0.010442655,-0.07045147,0.027882127,0.07054811,-0.04260646,0.05547265,0.018897574,0.01644022,0.063966334,0.0077926028,0.013257385,0.0068501467,0.023785628,-0.02795824,-0.014150256,0.07719881,-0.01800387,0.06481641,0.052583467,0.022843719,-0.014579439,-0.085325204,-0.031971317,-0.020376295,0.06956602,-0.015923537,-0.018745065,-0.069138594,0.032400917,0.051453542,0.062177647,-0.011508267,0.044520296,-0.03416961,0.050374135,-0.0534026,0.0036739353,0.058937795,-0.014286313,0.03252864,0.058046494,-0.049581565,0.091179915,-0.020178651,-0.062453013,-0.03610314,-0.0741001,-0.02645778,-0.0063301944,-0.042121466,0.043934785,0.05985674,-0.06423972,0.11724239,-0.08746899,-0.0360873,-0.07982709,0.012419827,-0.011889904,0.048375413,0.017303746,-0.019528454,0.053189524,-0.03156217,0.09728962,-0.03350108,-0.060799196,-0.016863594,-0.02834722,-0.0382224,0.06342675,0.06642363,-0.017503724,-0.04768413,-0.0073375357,-0.048080772,-0.08766052,-0.029614585,0.02291086,0.008887034,-0.024207912,-0.059812993,-0.047419623,0.0863184,-0.03352656,-4.8186908e-33,0.13180958,-0.093089044,0.11408467,-0.10967304,0.0006523581,0.016636848,0.074899085,0.0406181,0.048122067,-0.040876377,0.08695635,-0.008427781,0.010948977,-0.012472186,0.0116762,0.0064776307,-0.05370322,0.028549455,-0.06511011,-0.083348,0.039227515,-0.060494717,-0.061499186,0.053583857,-0.037013154,0.009849453,-0.08070836,0.07007448,0.029387087,0.082093,-0.040272076,-0.06369594,-0.022604011,-0.06850287,-0.056666184,-0.012910404,-0.075408846,-0.022976458,0.02185596,0.027774714,0.06382706,0.034352172,-0.035285767,-0.007949968,-0.004966414,0.020422729,-0.0451128,-0.0104448395,0.057376858,-0.06288793,-0.0037877082,-0.0125452,0.009472923,0.026013501,0.02919786,0.094178416,0.034486182,-0.008845651,0.0017577768,-0.063517265,-0.05175498,-0.08668162,0.023591885,-0.007972599,0.073979184,0.08719729,0.00548016,0.07941125,0.016454851,-0.010539091,0.020355223,0.073418215,-0.104546756,-0.042371042,-0.033961125,-0.02604716,-0.025887238,-0.01657846,-0.02432375,-0.0106631955,0.0022705293,-0.04523876,0.011467104,-0.09871825,0.0048340005,-0.019912416,0.040337037,0.06224971,-0.055433813,0.053086292,0.00950327,0.062283427,-0.007745827,0.0035830513,0.03056967,-4.749832e-08,0.0049565337,-0.04105523,0.06028822,-0.036126934,0.026055425,0.055634297,-0.03852038,0.01477105,0.050761018,-0.0327865,-0.019649088,0.07648578,0.027672347,0.014389322,0.024046527,0.012907079,-0.09274504,-0.051311806,0.021358091,-0.04411546,-0.114186995,-0.01818917,-0.003914101,0.043754812,0.027621357,0.011277304,0.025304457,0.12886266,-0.02137138,0.026954057,-0.018029792,0.040717203,-0.066368714,0.018285053,-0.05219503,-0.005466628,-0.015471822,-0.04915798,-0.09096965,0.09204016,0.11407587,0.060050182,-0.062591664,0.03567719,0.037347294,0.017849682,-0.009751268,0.023454577,-0.020987362,0.05848004,0.016437171,0.023405217,-0.112474285,0.0028089504,-0.0043064947,-0.0005020954,-0.043418065,-0.018649237,-0.091325805,0.0061617433,0.09546634,-0.00598432,0.1648458,-0.060907174 +2.3.1.112,1-Aminocyclopropane-1-carboxylate can act instead of malonyl-CoA.,384,1.0,-0.0046053114,-0.08832543,0.013722016,0.019143093,0.044840135,0.012670681,-0.00847577,0.041990794,0.06668513,-0.061610416,-0.0025223617,-0.011990355,-0.060128905,0.049823597,-0.022364762,-0.004332627,-0.010149786,-0.007467575,0.027421096,0.06948526,0.031865343,0.050714307,-0.02639535,0.036764916,0.033966497,-0.05397432,0.00061953504,0.08025825,0.0052469675,-0.060705185,0.019210713,0.014325879,-0.022302276,0.0374586,0.021102004,0.10052427,-0.054757353,0.020001357,-0.025819002,-0.07916363,0.031739242,-0.08240822,-0.029686313,-0.013592128,-0.098807335,-0.06277341,-0.03746683,-0.024067877,0.042027365,-0.02273062,-0.01855118,-0.018236663,-0.10752135,0.0039155786,-0.03299803,0.011696026,-0.12340736,0.0827524,-0.03335118,-0.0033073565,-0.023053903,0.085219994,0.0056538065,0.02254461,0.010641809,0.021641918,0.039316054,0.00066229294,0.02888258,0.01992764,-0.055494715,-0.08125595,-0.01334026,0.036786675,0.053577676,0.02010672,-0.04928005,-0.079835065,0.039629593,0.018655216,-0.0409172,0.08399418,0.055885542,0.054771744,-0.013934015,-0.0033401577,0.03316644,0.010003465,-0.013832106,-0.054980043,0.06759951,-0.006142994,0.1504915,0.016300077,0.007505561,0.08014625,0.036605917,-0.03648197,0.00021013427,-0.0008889557,-0.05706747,0.008032134,-0.07169385,-0.008149149,-0.07257914,0.037466075,-0.002382844,0.023528287,-0.0054430426,-0.03671564,-0.017094584,-0.042830635,0.05599839,-0.05159733,-0.081969276,0.050557725,-0.041887946,0.029399972,0.005811007,0.05377343,-0.029606724,-0.026255224,0.012731742,0.008122857,-0.034709666,0.046959672,0.011139906,-5.642688e-34,0.078160465,0.005706455,0.05891603,0.014149756,-0.0014990686,-0.05828481,-0.014367639,0.039250072,0.0043965224,0.065152556,-0.027508445,-0.057254776,0.017088968,-0.018402953,-0.025219439,0.004885041,-0.10973517,-0.027490055,0.048012223,0.027418535,-0.024689242,0.14582755,0.028148372,0.028479185,-0.03312546,0.0029758422,-0.0352248,0.014269756,0.06948736,0.01854913,-0.08631927,0.0016403883,-0.109129034,-0.0019356718,-0.0048589394,0.017139332,-0.04444495,-0.031728946,0.033752855,0.046325535,0.10071137,0.0069620707,-0.048001356,-0.07351393,0.058644682,0.0052650054,-0.03591553,0.10915821,-0.10300321,0.008374091,0.054090243,-0.0570107,-0.046253763,0.085855916,-0.062959544,0.0574511,-0.044023238,-0.018457076,0.015419516,0.013353023,0.003217775,0.011057693,0.04507687,-0.007711035,0.046083327,-0.013596819,-0.096711576,-0.031953014,-0.101994105,-0.0047198213,0.008038438,-0.018766187,-0.019111829,0.046931446,0.061003935,-0.056447066,-0.017482307,0.01752343,0.07512412,0.03659662,0.018583618,-0.02385331,-0.019630108,-0.03985486,-0.03703779,0.027511552,0.011933895,-0.027663263,-0.025932446,0.06630713,0.09286705,-0.07967346,0.030446153,-0.022792552,-0.0669222,-1.4994892e-33,0.059094515,-0.16237128,0.020986514,-0.026363626,-0.001557171,0.02430768,0.062689885,-0.10921648,0.012533334,0.0573791,0.09017811,0.033011403,-0.03372921,-0.049572762,-0.04359589,0.025962872,0.018442264,0.024120314,-0.008089888,0.034545597,-0.08096193,0.031944197,-0.076618515,0.049265187,0.03429666,-0.018585987,-0.038880926,0.055904757,0.07136636,0.1041531,0.03820732,0.02826726,0.0108913435,-0.024575988,-0.025021179,0.06778061,-0.08329411,-0.04557175,-0.044113934,-0.04553065,-0.10824856,0.0017666754,0.002678205,0.027817547,0.089443795,0.016628416,-0.0666349,-0.022306291,0.02806612,-0.038038667,-0.017467786,0.05815748,-0.04668031,-0.010010995,-0.045807548,0.10573385,0.033078007,-0.037193187,0.03548018,0.01959294,-0.03966363,0.010451523,-0.055333067,-0.043885034,0.09345731,0.085580036,-0.06549876,0.013098465,0.10383884,-0.04452566,0.10655057,-0.037142955,0.09321332,-0.0041655228,-0.017207196,-0.029756034,0.031217204,-0.006286159,-0.010555472,-0.0646331,-0.016325803,0.011489816,-0.011569832,-0.04775093,-0.079683475,-0.03990355,0.06169761,0.10389508,-0.025671443,0.05169695,-0.019320207,-0.016829088,0.069730304,0.07716687,0.118611336,-2.8081171e-08,0.06409266,-0.02147292,0.0243889,-0.075820856,-0.041133,-0.0004269376,0.014627297,-0.02626091,-0.033818766,-0.06334209,-0.03498363,0.06191752,0.0072181355,0.107594535,0.025214983,0.038238294,-0.052303918,0.0918083,-0.06789513,-0.04078405,-0.11781334,-0.004850408,-0.085751,-0.026233908,-0.06320584,-0.07138337,0.06360842,0.070482254,0.042964693,0.004521681,-0.0062326305,0.04575589,0.01115611,-0.0010797431,-0.02230351,-0.016765272,-0.030896127,-0.028578341,-0.02863862,0.009169312,0.065684706,-0.023866491,-0.028084831,-0.036509395,0.04672798,-0.007474201,0.015967255,0.0015818614,-0.03585387,0.021423362,0.04925708,0.075916566,-0.12141077,0.008727452,0.019996302,0.006122965,-0.043992087,-0.017917288,0.041139588,-0.11060523,-0.09090264,0.008319972,0.1213266,-0.03442685 +2.3.1.115,"The 6-position of the glucose residue of formononetin can also act as acceptor; some other 7-O-glucosides of isoflavones, flavones and flavonols can also act, but more slowly.",384,1.0,-0.07542923,-0.12274061,-0.08017915,0.06794418,0.029097293,0.048446268,0.017375771,0.0007269631,0.10311036,-0.014619393,0.02853317,0.084571674,-0.14703172,0.017636303,-0.021753335,-0.04685463,-0.042468864,0.03891311,-0.06162163,0.009353088,0.067138076,-0.02234849,0.060233403,-0.074519545,0.016536577,-0.04898198,-0.006635502,0.0041533937,0.087849416,-0.108255446,-0.01786332,0.0107418755,0.03214365,0.028940417,-0.078537256,0.09988602,-0.009548399,-0.04354601,4.1258543e-05,-0.042779196,0.0715208,-0.053408425,0.051204547,0.0011530415,0.039747242,-0.110914536,-0.02379104,0.01623791,0.061426092,-0.029196747,-0.03795261,-0.065555796,-0.054721944,0.08318046,-0.024835384,-0.028371751,-0.08234831,-0.01226033,0.018930323,-0.030689543,-0.009326746,-0.046581056,-0.0010679383,-0.01223805,-0.07737709,-0.06801312,0.013288561,-0.052747108,-0.05493606,0.056219343,0.06600872,0.026675403,-0.05751141,0.028965209,0.053482156,0.06973518,-0.100086525,0.0049207737,-0.039937582,0.015147247,0.07942094,-0.02428951,0.1021437,0.106971145,-0.0745666,-0.054092567,-0.060151886,0.0742589,-0.0044515184,0.018424649,-0.0008320608,0.03958951,0.014131996,-0.005206762,0.040950436,-0.009601836,0.0566016,-0.026727958,0.010066278,0.024712224,-0.03294209,-0.02131202,-0.069456555,0.006418599,0.0034973607,0.033984687,-0.03872226,-0.019196285,0.035296183,-0.037702814,-0.06648448,-0.06159022,0.04349867,0.011843115,-0.05863314,-0.01823555,-0.009255609,-0.037261255,-0.03859056,0.009604654,-0.09351478,0.058044523,0.037594747,0.018658824,-0.041262895,-8.228098e-05,-0.015417932,1.1565827e-33,0.04794399,-0.042529706,-0.0026562538,-0.027843881,-0.022603106,-0.017109266,0.01791036,0.013795465,0.04283528,-0.01331753,-0.15501697,-0.03582301,0.008822146,0.050986987,0.024023963,-0.01342151,0.0340409,0.016180208,0.06053247,-0.056208964,0.05630329,0.027768826,-0.040478427,-0.023033185,-0.0096008135,0.034120735,-0.10570448,0.06090612,-0.017221525,-0.021543099,0.024138037,-0.04579807,-0.0034871462,0.03987036,0.03692736,0.058460183,-0.056444414,-0.010912445,-0.029547144,-0.04900531,-0.010232159,-0.0025172927,-0.0854515,0.028218664,0.04233698,0.042673934,0.00069425185,0.04967261,0.048196033,0.12144994,0.04683548,-0.017519206,0.0030431014,0.010905315,-0.00017057857,0.071378134,0.0005070541,0.010625642,0.0030622887,0.017533377,0.029464683,-0.020543696,-0.0046394975,0.009942592,-0.07516232,0.101480894,-0.075582534,-0.042972885,-0.054885324,0.013796428,-0.0013388369,-0.02841213,-0.031781305,0.026381476,0.104191266,0.013419995,-0.027892664,-0.0875032,-0.03518014,0.0050796205,-0.0072349044,-0.042554412,-0.02986543,0.036645137,-0.1282887,0.05887272,-0.016282795,-0.08578313,0.05530743,0.012921164,0.0067004925,-0.04626967,-0.078160055,0.012823753,0.05671286,-3.2151023e-33,0.066423334,-0.09575578,0.05121782,0.009468812,-0.001086894,0.07800247,-0.004745878,-0.08633662,0.0010324436,0.03692626,0.045836005,0.0064769993,-0.026134985,0.015897123,-0.05499892,0.05472926,-0.039121427,0.11316671,0.009226673,-0.0058322065,-0.113423094,0.04323949,-0.03129625,0.083342575,0.05062606,0.0076771732,0.062808186,-0.03792586,0.013796204,0.070848435,-0.029178705,-0.026167884,-0.03917203,-0.016886115,0.061413504,0.031237587,-0.056693394,-0.01184697,-0.042370968,-0.024939306,0.01523368,-0.0032850236,0.0581855,0.032443564,0.10431293,0.0067707943,0.0077238837,-0.012572613,-0.07322023,0.0072373534,0.0053322734,0.05688548,-0.028535914,0.05071228,0.09794296,0.12382792,0.019786129,-0.018355254,0.039286006,-0.0029037758,0.0010453258,-0.10444685,0.048461884,-0.015392623,0.11456739,0.045646824,0.039446052,0.06591489,0.069885,0.00465624,0.05285399,-0.09870527,0.013242937,0.0972648,0.029871231,-0.05738282,0.041401256,-0.03001774,-0.094695725,-0.07896402,-0.035708077,0.014254505,-0.024860993,-0.11861036,-0.03663387,-0.03645584,0.06830952,-0.047025003,0.009709838,0.09253471,0.0006964717,0.09017611,0.059547342,-0.021376269,0.028934393,-3.4811542e-08,0.021333834,-0.03688954,0.067879036,0.013695031,-0.01399388,-0.005351144,-0.008700918,-0.004721776,-0.024677726,0.029976834,-0.0139819365,0.10011806,0.0651155,-0.085894436,0.004406926,-0.018638052,-0.050221205,0.008613232,-0.0073202187,0.0118757645,-0.09496933,0.012228104,-0.06282942,-0.018988172,0.0045485087,-0.12625353,-0.022139108,0.104074076,0.041924242,0.0061710477,0.07252552,0.04563967,0.03054379,-0.021466726,-0.09576333,0.053255733,0.039743256,-0.028433733,-0.020464696,0.052112516,-0.036740817,-0.024959598,-0.018176997,-0.016616132,-0.012462041,0.039827466,-0.00022538377,-0.014724856,-0.0035398544,0.02804284,-0.0029245324,0.03282965,-0.061838344,0.040680192,-0.026136365,-0.024963612,-0.03742203,0.0033683707,0.035177376,-0.034820743,-0.0693946,0.021059737,0.111491784,-0.019088306 +2.3.1.117,"Involved in the biosynthesis of lysine in bacteria (including cyanobacteria) and higher plants. The 1992 edition of the Enzyme List erroneously gave the name 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase to this enzyme.",384,0.99999994,-0.083989605,-0.082269475,-0.09381284,-0.015704079,0.10271175,0.05834782,-0.080509745,0.033181593,0.009122334,-0.0024391238,0.04570348,-0.04855287,-0.041974023,-0.018636772,-0.07314163,0.059572257,-0.16432565,0.018540826,-0.012902516,-0.05311012,0.069060385,0.104392014,-0.056267753,0.024553128,0.05324994,-0.045192573,-0.050221283,-0.027634177,-0.065135814,-0.0025458366,-0.016052892,-0.026450407,0.0048152995,-0.11362178,0.116897374,0.037975036,-0.08205826,-0.033198796,0.15535031,0.038171694,-0.037900284,-0.057461362,-0.026422404,0.008681785,-0.061172467,0.06309979,0.07476444,0.031960182,-0.0064370763,-0.014246257,-0.039317947,0.034192465,-0.028495895,0.012154748,-0.083307885,-0.045137066,-0.06656457,0.051383603,-0.0050050854,0.03784513,0.059328824,0.06299195,0.012313555,-0.014613269,0.04168007,-0.0434361,-0.03443004,-0.061856095,0.046242714,-0.061709013,-0.037327662,-0.08500723,0.038656335,0.056644127,-0.0023619465,-0.007126187,0.028144786,0.046540927,-0.031645216,0.011713229,0.045565505,-0.06861974,-0.009635288,0.05179592,0.0089656655,-0.07429144,-0.029530508,0.082136035,0.03653721,0.018245786,0.07688412,-0.05714144,0.04857787,0.0067283614,-0.07494237,0.031095136,0.02950651,-0.007121443,0.049260806,-0.03153375,-0.041688934,-0.019875333,-0.03534891,-0.02000634,-0.0048296475,-0.028556794,0.042223904,0.027384767,-0.0042205537,-0.03660296,0.0032784916,0.045345582,0.014659147,0.030314669,-0.034920823,0.069590315,0.021892216,-0.049546853,-0.02507758,0.002803668,0.03486323,-0.012766934,0.06621036,0.07951455,-0.05142673,0.09365389,-0.122585766,2.2658458e-33,0.04518284,0.02217521,0.033258826,-0.0074301697,0.063433155,-0.052511584,-0.05996958,-0.036326542,0.011141901,-0.026957678,-0.08634969,-0.11037934,0.09853567,-0.04513599,-0.05357713,-0.005048836,-0.09896383,-0.030484494,0.08439504,0.0365259,-0.013182213,0.06988732,-0.026996693,0.086803205,0.0006217121,0.071316466,0.007572708,-0.005367823,0.089139655,-0.004011706,-0.01413713,-0.16258161,0.0008779035,-0.03219526,0.12675537,-0.055146497,0.009067767,-0.088896826,0.029454904,0.026941888,0.030947288,0.061730143,0.01060432,-0.0020389156,0.03622432,0.04506656,-0.032274846,0.10627372,-0.0055785477,0.009772113,0.048295695,-0.03297566,0.06554783,-0.015018841,-0.03451437,-0.0076368055,-0.05725464,0.04540377,0.048670225,0.03988825,0.0100478055,0.046052415,0.04717248,-0.02688782,0.040423356,-0.028407447,-0.06943897,-0.038295258,0.015189445,0.040002428,-0.11619854,-0.05796701,0.06584705,-0.014630622,0.12605183,0.0046607982,-0.03974557,-0.014973624,0.011523907,-0.03904843,0.0011753496,-0.0004392852,0.024626624,-0.01951952,-0.013677561,-0.04323318,-0.05224581,-0.061828766,-0.023632206,0.054470554,0.0149713,-0.06556683,-0.017043207,0.0176548,-0.0076567214,-3.3391416e-33,0.018408816,-0.05294277,0.06361863,-0.030891672,-0.0076972498,0.019708026,-0.057624735,-0.049811225,0.046666276,0.010554645,0.08492199,-0.006846324,0.0076759933,0.008023814,0.039689966,0.0013978673,0.050599158,0.03387937,-0.017019305,0.020238971,-0.0017924039,-0.00566379,-0.009409122,-0.021451302,0.005397002,0.039757576,-0.009919623,0.07444971,0.080495015,0.013886858,-0.02131402,-0.0025316076,-0.03666046,-0.031998273,-0.018060029,0.016203444,-0.0008565501,-0.025437092,0.038276087,0.03052723,0.021315103,-0.014779284,-0.0044154446,0.064409606,-0.038562644,-0.018737428,-0.08769985,0.019134698,0.0057888064,-0.035623074,0.004553833,-0.03755341,-0.050023187,-0.02022924,0.050889324,0.020417713,0.0549104,0.07052552,-0.0108995335,0.028387029,0.0036576698,-0.08625856,-0.04186817,-0.034954585,0.056089986,0.029028434,-0.0682648,0.086356744,0.07175065,-0.044316445,0.094703935,-0.016202793,0.04025099,0.03829323,-0.078823395,-0.0065147844,-0.04637616,-0.13106433,0.0012157685,-0.011947843,-0.020889243,-0.00582265,0.06034302,-0.025446385,-0.049733166,-0.0490416,0.05957893,0.12879246,0.03344027,-5.5981032e-05,-0.0021449467,-0.033141997,0.02330094,0.07763345,0.058486015,-3.87779e-08,0.07826357,-0.07373776,0.04879162,-0.0034331689,-0.0067101168,0.058796514,-0.0098501835,0.054466628,0.008836627,-0.020130636,0.019159012,0.039432827,-0.0026604673,-0.01596037,0.06647127,0.028478716,-0.044323083,0.06497597,-0.022251686,0.033998597,-0.039186817,0.006726801,-0.092878655,-0.013198677,-0.0036582814,-0.07738697,-0.019457068,0.0044188313,-0.0015233835,-0.071988426,0.049821615,-0.026270373,0.0323854,-0.05951402,-0.10899772,-0.009004618,-0.07345288,-0.05857924,0.027055785,0.0035500173,-0.032268472,0.024110401,-0.10470757,0.07406865,-0.008685373,0.0009292284,-0.024346495,0.024681723,-0.003285926,-0.0032792983,0.021857105,-0.0052200085,0.016542908,-0.01883393,-0.01182403,-0.015387866,-0.05220402,0.014359077,-0.0040644617,-0.0684281,-0.0826105,0.10896404,0.16869164,-0.027007228 +2.3.1.118,"The enzyme from liver, but not that from bacteria, can also catalyse N-acetylation of arylamines and N,O-acetylation of arylhydroxamates.",384,1.0,-0.044620894,-0.08223515,-0.12404496,0.014209635,0.0021554474,0.026435548,-0.015660983,-0.012807538,-0.03384102,-0.050073285,0.005294787,0.018124955,-0.057387233,0.017605009,-0.066052414,0.05863118,-0.06348825,0.0024934988,0.06914459,-0.056220554,0.023641996,-0.009355495,-0.06479055,-0.09859312,0.058063976,0.025413495,0.024532998,-0.03806815,-0.016565777,-0.087804615,0.03407328,-0.029238313,0.047796752,-0.067600064,0.08435143,0.047027383,-0.054935906,0.031013677,0.049071725,0.036946416,-0.021027025,0.039082002,0.011820697,-0.04957085,-0.024074947,-0.03246128,0.04021383,-0.0027827292,0.033877715,-0.0025303613,-0.097839445,0.014774854,0.020964663,-0.011111636,0.039669238,0.019377274,-0.06526371,-0.1395843,-0.023181438,-0.00784688,0.031902134,-0.014999223,0.017877437,-0.022725945,0.00859308,-0.04880414,0.074915186,-0.09335323,-0.008950694,0.01787239,-0.041204628,-0.06386664,-0.046162337,-0.0014925901,-0.015755603,-0.05056943,-0.03327111,-0.05805123,0.09364109,0.03832548,-0.033700306,0.009008506,0.009112971,0.052230395,0.009752039,0.036636256,-0.026067382,0.051226635,0.0639559,0.036705818,-0.06310829,-0.039799474,0.051973995,-0.05390081,-0.044748075,-0.027209599,0.067376785,0.044640433,0.029342495,-0.0016306891,0.012692104,0.040635023,-0.04851873,-0.093230434,-0.030485934,0.052094784,0.035997927,0.11142419,0.051436704,0.032033633,-0.06294452,-0.0055575534,0.0521756,0.010327004,-0.07083805,0.123056464,-0.0068855453,-0.116653934,-0.06602412,0.02142485,-0.020981053,-0.010800116,0.016389966,0.09277911,0.030632658,0.071241096,-0.018971574,8.636608e-34,0.06143989,0.080855325,-0.0071968487,-0.055725966,0.059184294,-0.0032113914,-0.0591285,0.01972802,0.070812955,-0.08089794,-0.053943433,-0.04712366,0.07355895,0.033318534,0.029743373,0.052097168,-0.0092559345,0.014791527,0.061229255,0.009493534,-0.009395271,-0.0371378,-0.038892046,0.0062396904,-0.01567938,0.012917002,0.007989066,0.04754826,0.036764562,0.0006986537,0.009648194,-0.037804086,-0.007067704,0.025518624,0.03741444,-0.0062342347,-0.007831794,-0.0107138185,-0.007061614,0.053295262,0.0010403139,0.07799903,-0.00038662247,-0.019806333,0.014833922,-0.04683907,-0.09753126,0.069616586,-0.011414554,0.06675137,0.050595716,-0.035055842,0.10471432,-0.01962396,-0.002916247,0.035445128,-0.07408352,0.022698132,0.02814946,0.014286411,-0.0012925031,-0.03263536,0.03478319,0.010365364,-0.051171046,0.025111966,0.024479384,-0.036162235,0.047722794,0.056986235,-0.096461736,-0.01650833,0.05624103,0.01773805,0.011961399,-0.053448293,-0.05777848,-0.015265111,0.09601572,-0.005071193,-0.02988167,0.018776987,0.05515638,-0.04259964,0.0076437616,-0.03158166,-0.0079074465,-0.04196391,-0.038357478,0.040477347,0.02679024,-0.10474217,-0.10491956,0.028315598,0.044979718,-2.4990576e-33,0.09807837,-0.12967183,0.019421974,-0.08944128,-0.09984317,0.1091454,0.009771008,-0.04221786,0.017504523,-0.0071315123,0.015844729,0.017914958,0.050858967,-0.032335892,0.04183696,-0.0953109,0.06432056,0.08047011,0.024544831,-0.024338823,-0.049587544,0.014355033,-0.03821115,-0.043998286,0.016617175,0.045072503,-0.084166154,0.0014195738,0.022440402,0.052819666,-0.0016535727,0.004864814,-0.025299862,-0.028380968,0.041145477,0.107287556,-0.00063520146,0.026648125,-0.045764796,-0.040941954,0.0443166,-0.0035125436,-0.014486542,0.04765098,-0.006356688,0.022098819,-0.09222416,-0.03929384,-0.011965905,-0.09740645,0.082920805,0.0057816277,-0.033902783,-0.031784654,0.003698808,0.075701535,0.036063395,0.022898566,0.030155143,-0.066200614,-0.09495236,-0.04340346,0.013417115,0.009334997,-0.014696723,0.08197972,-0.033435263,0.061472338,0.0076801726,-0.046773028,-0.017550448,0.031080239,0.042303365,0.16875553,-0.011766158,-0.021796158,-0.015933318,-0.08588347,0.0014796809,-0.076854825,0.010722291,-0.046699125,-0.00938727,-0.018846814,-0.06699718,-0.049007747,0.063233554,0.067549236,0.001461402,0.02895053,0.005224357,-0.012139091,-0.07130795,-0.036960136,0.014151704,-3.1601505e-08,0.0646438,-0.029351564,0.03718916,-0.021450479,-0.046405774,0.083411105,-0.0065804576,0.00096578384,0.07377229,-0.063094236,0.008245397,0.13934144,0.031801507,0.036609285,0.028736332,0.011311206,-0.032110337,-0.05975561,-0.02840608,-0.015199184,-0.13512918,0.051801495,-0.045907073,0.058141246,0.0020883714,-0.04741185,0.0578183,0.042582758,0.01944104,-0.03567923,-0.034026787,0.0037318894,0.0044690445,-0.014397028,-0.012917915,-0.02404641,0.056087658,-0.09189535,0.008334056,-0.013763288,0.035712644,-0.007881286,-0.12978047,-0.021448003,0.050142173,0.03755683,-0.026292171,-0.016418518,-0.03437492,0.019408325,0.042450693,-0.011429021,0.0010061716,-0.091848426,-0.0889651,-0.019623613,-0.023377117,-0.121713616,0.030401547,-0.0038722432,0.08020599,0.061582103,0.18512155,0.012634509 +2.3.1.119,Icosanoyl-CoA can act in place of stearoyl-CoA. The membrane enzyme brings about the elongation of these long-chain fatty-acyl-CoAs.,384,1.0,-0.068021424,-0.09771364,-0.06797808,-0.0070097363,0.028600147,-0.023460872,-0.045146964,-0.0007073048,0.018431762,-0.015519832,0.08286218,-0.0640385,-0.05850901,0.025833465,0.051916987,-0.0039770305,-0.06429713,-0.0027918047,-0.008922344,-0.05740168,0.057840813,-0.03220256,-0.068902604,-0.011479929,0.015633136,0.018083524,0.043074965,-0.023775328,-0.007940539,-0.071745306,-0.05049051,-0.060822617,0.044421792,-0.069813445,0.045635775,0.03364109,-0.024284491,-0.04022752,0.03671888,-0.021429203,0.111183144,-0.07219448,0.020429842,-0.041640893,-0.01347914,-0.062301405,-0.027285049,0.05360816,-0.022907272,0.003723069,-0.028293552,-0.10008524,-0.077628605,0.08553044,-0.034878317,0.037273318,-0.100523785,-0.05364477,0.0045123706,0.025741879,0.06677349,0.012230405,-0.00091293285,0.06709817,-0.046792984,-0.051382076,0.06727962,0.0043015764,0.05699153,0.020147305,0.010018108,-0.01789944,-0.059958275,0.032473974,0.044160537,-0.013680135,-0.0028870273,-0.05866232,0.051525876,0.004845514,-0.007310445,0.07242645,0.047728058,0.04626618,-0.02693265,0.033101656,0.025510475,-0.052394982,-0.026665576,0.03475933,0.0702568,-0.052744415,-0.0018269317,0.030106084,-0.10279308,-0.03705157,0.067274876,0.016769102,-0.0090679405,-0.015537956,-0.023856448,0.008499669,-0.038593072,-0.0123061305,-0.039888944,0.027454184,-0.068711706,0.005357387,-0.013734568,0.02844936,-0.019077517,-0.035866827,0.07148014,0.019256344,0.026418108,0.009470002,-0.019623628,-0.011819378,-0.009088424,0.12762636,-0.08469329,-0.0064645982,-0.043646622,0.051930375,0.025707439,0.031241795,-0.10032167,-2.295312e-34,0.0071902904,0.00615653,0.044993836,-0.02853308,0.033524986,-0.12169355,-0.03612496,0.04406251,-0.098490305,-0.058053777,0.0028325429,-0.0827758,0.018774189,0.0552849,-0.021510556,-0.011110039,0.0015683172,0.05837794,0.026246833,0.005639848,-0.027846636,0.07488728,0.0011058837,-0.07746551,0.03529513,-0.044585306,-0.09412257,0.03129421,0.016068075,0.040989086,-0.06597697,-0.07620687,-0.045204096,0.052892264,0.032011364,0.0047989036,0.016749434,-0.052758757,-0.07202858,0.06073639,0.036890633,-0.002192862,-0.06660971,-0.024542311,0.017054617,-0.020551836,-0.022461712,0.05834225,0.04214616,0.0051947716,0.101041704,-0.008307884,0.025057018,-0.022601029,-0.0192745,0.065171815,-0.05931864,-0.042054415,0.01598001,-0.02301622,0.06460952,0.023439493,-0.07350323,0.03517817,0.025636135,0.05627709,-0.1001642,-0.02315133,-0.017231734,0.041658405,-0.017798346,-0.08296444,0.012770485,0.061366055,0.08150838,0.016455118,-0.04048261,0.044062812,0.03345495,0.0111697465,0.03504133,-0.019519087,0.056733273,-0.022038154,-0.008605446,0.019522881,0.034634847,-0.026341936,0.03547915,0.042883385,0.030472718,-0.037386853,0.0026252707,0.014458396,0.002981944,-2.3845742e-33,0.15614599,-0.11346735,0.03312191,-0.1116599,-0.07322871,0.0837381,-0.043609478,0.062094558,0.06315485,0.016798515,0.07461833,0.009543978,-0.045708466,-0.03286435,0.025284365,0.036137354,0.032964904,-0.029709252,0.026436105,-0.0028301233,-0.021359263,-0.023381341,-0.021733018,0.03848832,-0.0335185,0.011847071,0.033467915,0.061654247,0.01839186,0.05712542,-0.051126532,-0.08023065,-0.04154639,-0.047134634,-0.029895872,0.0436149,-0.054268174,0.04441611,0.0032738817,0.0023795047,-0.051770113,-0.043103408,0.06364901,0.0033924954,0.03508721,-0.050228473,-0.016063621,-0.05084513,-0.0563107,-0.0983145,0.021199822,0.012269216,-0.006770341,0.06359118,-0.018548742,0.12877677,0.0025815542,0.054060243,0.04065988,-0.102414325,-0.08611597,-0.054748345,-0.0153677445,-0.11362485,0.1348559,0.06507083,-0.048945647,-0.082149014,-0.012645229,-0.05070932,0.057971206,0.09080631,-0.030021278,-0.010258541,-0.056223154,-0.053607058,-0.055573586,-0.08007618,-0.05592302,0.0027355747,-0.03805897,-0.0064487066,-0.006885285,-0.02461423,-0.07604039,0.0021688293,0.057685565,0.043897875,0.013155333,0.054372337,0.030835899,0.010709318,-0.005012792,0.04576827,0.059788577,-2.945999e-08,0.03504935,-0.016926793,0.011118066,0.019503715,-0.06877327,0.022282215,0.0049337866,-0.056461815,0.07362998,-0.012467735,-0.024420964,0.12032623,0.103526406,0.049409367,-0.006435118,-0.041022543,-0.02547997,-0.027427107,0.013120064,-0.052033678,-0.10410071,-0.015171068,0.05509543,0.049635123,-0.010082596,-0.04052903,0.06886397,0.044423655,-0.0066910246,0.03325064,-0.07346093,0.022296347,0.033958387,0.06933842,0.07713895,-0.020253956,0.019467887,-0.091468796,-0.04924967,0.08210748,0.10388568,-0.0031538103,0.0030124816,0.016199762,0.1143462,-0.005682048,0.01946608,0.046637617,0.0010091909,-0.030924326,0.008953118,0.035111945,-0.08943441,0.009991846,-0.019788718,-0.0351335,-0.018427039,-0.036235757,-0.09328132,0.1169313,0.015651291,0.033816632,0.17327611,-0.026350806 +2.3.1.121,Long-chain unsaturated acyl-CoAs are the best substrates.,384,1.0,-0.09658381,-0.0648387,0.010950518,-0.0109996805,0.04130042,0.026382927,-0.104482904,0.0725124,-0.04447419,-0.05985818,0.02772779,-0.029150283,-0.054641265,0.0565661,0.011595497,0.02699142,0.06692182,-0.0037955488,0.06809313,-0.049248256,-0.006406707,0.010484345,-0.040961508,0.009755707,-0.02133786,-0.05254439,-0.008131536,-0.04852793,0.029101051,-0.120214984,-0.01655426,0.013784455,-0.011426315,-0.024727779,-0.009218519,-0.0075887246,-0.024351774,-0.06718381,0.06606176,0.0033218027,0.05220017,-0.04484222,0.045560747,-0.004370352,-0.05343709,-0.12629056,0.02951211,-0.027070327,0.015200719,0.02417253,-0.0025651697,0.020053044,-0.053199165,0.08710533,-0.022254648,0.009372876,-0.08930191,-0.014676443,-0.042288788,-0.004997862,0.029183405,0.0049799937,-0.055866394,0.026341176,-0.04302152,0.02301648,0.017467357,0.040898964,0.045496695,0.0780809,-0.064443916,-0.04668841,-0.056014713,0.010932926,0.0988783,0.06361827,0.030354034,-0.13767055,0.033919573,0.045574713,-0.07118752,0.04039048,0.013864197,0.046295445,0.063125,-0.038910717,-0.0134896105,-0.03322287,-0.08199594,-0.047025587,0.052274264,0.040145684,0.024792915,0.011436567,-0.08517873,0.0655458,0.040932517,-0.0051153875,0.0066353944,0.0018573663,0.0060411007,0.065057136,-0.044276234,-0.01739325,-0.086436026,-0.04425536,-0.013931268,0.05746067,-0.0034982085,-0.012124258,-0.0032044696,0.0369627,-0.0036542935,-0.017832438,-0.06678546,-0.0012682041,-0.047310017,0.03288217,0.024610134,0.017175715,-0.05485753,0.035179406,-0.035087533,0.10542292,0.0051039723,0.02162681,0.034144696,-1.5704096e-33,-0.007653344,0.040871672,0.014472429,-0.028793981,-0.03395068,-0.027473144,-0.10095865,0.022170033,-0.031036466,0.061050273,0.046799403,0.0013828587,-0.057724874,0.10093564,0.06368053,-0.11797101,-0.017477525,0.038621794,0.017382931,0.017242417,-0.04906202,0.042625237,0.053217366,-0.0072172405,0.0828838,-0.109549426,-0.018787703,0.10417911,-0.070691474,0.021647954,0.0042357347,0.021998787,0.03637262,-0.00778355,-0.044896815,-0.040467907,-0.14570338,-0.014394215,0.024474228,0.045534912,0.07272769,0.102099486,0.03290112,-0.01752974,0.06701951,-0.056604814,-0.041683283,0.07478345,-0.025863193,0.034164608,0.04837202,0.012000589,0.0076720356,0.014545552,0.028443601,0.035165153,-0.018236117,-0.019552408,-0.00064420095,-0.04286692,-0.030974932,0.07543711,-0.045231953,0.01789909,-0.0270096,0.053612422,-0.04624395,-0.011226093,-0.0752622,-0.038830955,0.021741977,-0.00463981,0.030222174,0.0670831,0.027468383,-0.03285,-0.07214056,0.024235811,0.10181404,-0.024664978,0.05508845,0.026547216,-0.035241425,-0.014205814,-0.06752329,-0.07125471,-0.024214799,0.030233342,0.07087728,0.040659454,0.025015485,0.0045851646,0.07606198,-0.003884181,0.014147972,4.361465e-34,0.13995105,-0.119853854,0.05134814,-0.07339177,-0.054492835,-0.014549156,0.06113329,0.014568807,0.086026914,0.043113723,0.11035087,0.10207933,-0.08405309,-0.039459895,0.04684962,0.06553415,0.049389325,0.0028265978,0.040439136,-0.0520124,0.040543,0.04220499,0.028754553,0.029903082,0.031881087,-0.006434337,-0.02833445,0.014643477,-0.010210842,0.086154744,-0.019335635,-0.005629492,0.037400402,-0.048878934,-0.012659251,0.016280737,-0.0045696683,0.046095077,-0.043782536,-0.005906484,0.025568275,0.051953893,0.0011916007,-0.0016176775,-0.033519376,-0.014437194,-0.084627144,-0.08150976,0.057770535,-0.044636823,-0.045622766,-0.034440324,-0.036463153,-0.08585887,-0.0019237289,0.045347314,-0.026884021,-0.012954724,0.057896078,-0.13881394,-0.04551523,0.057082493,-0.017965138,-0.099541806,0.052506734,0.05307459,0.012410098,-0.0073563163,0.011108126,0.0020039096,0.082726054,0.07444523,-0.0050409287,-0.04355793,-0.039106887,-0.038918186,-0.015209316,-0.021292632,-0.034379218,0.014302933,-0.019373272,-0.043279707,-0.080754906,0.00414035,-0.020969635,-0.041981433,-0.0076437127,-0.036725607,0.01487043,0.06730837,0.04704383,-0.03824907,0.060454007,0.059779584,0.07150269,-2.0328581e-08,0.08063172,-0.052774638,-0.0041851616,-0.028180055,-0.08659655,0.011369426,-0.014105282,-0.028282993,0.06836542,-0.04723105,-0.010382474,0.099112764,0.0626134,0.07864546,0.036899224,-0.038193516,-0.041253977,-0.032560885,-0.027116973,-0.018378748,-0.105077766,0.039362524,0.03863133,0.053986736,-0.06918514,-0.004658825,0.09679347,-0.036621384,0.008617495,0.015704995,0.01472802,0.034213997,-0.019607415,0.04863631,0.10019877,-0.016337598,0.027471563,-0.059888016,-0.06555019,0.106386945,0.0034918445,0.0028266814,-0.028361153,0.018466605,0.072857924,-0.075091824,0.004191732,0.116460405,-0.056797687,0.06380421,0.01731331,-0.019884411,-0.090668455,-0.05399935,-0.029876065,-0.0708724,-0.029024934,-0.024415383,-0.071450666,-0.025460541,0.017880214,0.0054690433,0.13220772,-0.023442853 +2.3.1.122,"Catalyses the exchange of mycolic acid between trehalose, trehalose mycolate and trehalose bismycolate. Trehalose 6-palmitate can also act as donor.",384,0.99999994,0.026799787,-0.06677041,-0.06552683,-0.013244573,0.009452568,0.02001318,0.10568852,0.03345896,-0.004900784,0.0070959893,-0.012215258,-0.037087135,-0.045377426,0.006359851,-0.00031966413,-0.033202488,-0.0019478122,0.028043492,0.0035155579,0.00435709,0.028621007,-0.07088872,0.027018858,-0.091479324,0.04323139,0.007443346,0.005998327,-0.04868561,-0.0058908565,-0.07235322,-0.04280298,0.032800205,-0.02923861,0.004978005,-0.015796684,0.047862206,-0.07184109,0.011758629,0.047873043,-0.031904962,0.040916763,-0.053555116,0.05932142,0.0054222676,0.02823495,-0.028673772,0.03003053,0.077318445,-0.06770261,-0.009505056,-0.04373237,-0.0052547217,-0.048327815,0.01794405,-0.041273497,0.10843587,0.06577153,0.0049791764,0.00499441,0.05256065,0.08789594,-0.025912307,-0.036224846,0.024223907,-0.022422561,-0.12206438,0.02499794,0.06859965,0.066709615,0.012752415,-0.0042252745,0.020243963,0.023081949,0.003435393,0.049154866,0.027462183,0.027031401,-0.047219094,-0.015417039,0.050406285,-0.014081578,0.02769744,0.029428659,0.015149888,0.05145381,-0.06464334,0.049022105,0.0502151,0.02249584,0.028701756,0.0091877375,0.041855853,0.012314963,0.010240839,-0.1798389,-0.00082699157,0.026836764,0.0046311384,0.05850182,-0.0111815855,0.0007899604,0.034173053,0.014984201,-0.08980232,-0.025962856,0.0712775,-0.105463795,0.01687793,0.09662387,0.027866093,-0.0124847675,0.008094543,0.08450949,0.059002526,-0.0069148084,0.10480351,-0.018582346,-0.114850216,0.0010473905,-0.024626533,-0.0014554574,-0.002103467,-0.029899467,-0.016383436,-0.082977764,0.046952713,-0.024769679,4.473497e-33,-0.007916063,0.09135434,0.01491135,0.017503351,0.03530538,-0.054068297,-0.067787066,-0.05105481,-0.09874914,0.003989963,-0.041705996,-0.02845204,0.016627762,0.11223365,-0.11497244,0.041341286,-0.040314887,-0.010080499,0.055942018,-0.026319912,-0.0052579255,0.050777648,-0.091729574,-0.017039252,0.044813305,0.015388693,-0.0098139215,0.039611604,0.07875231,-0.041684583,0.0857923,0.008085255,-0.026130483,-0.012610769,-0.0061161797,0.012375884,0.043289393,-0.035586286,-0.047968045,0.010347173,0.045884904,0.020762397,0.07190858,0.016537864,0.03318062,-0.10537738,-0.060746808,-0.0037293183,0.004221357,0.038143218,0.008520476,-0.09538883,0.04172555,0.01861845,-0.061113365,-0.02930359,-0.042136528,0.0119299125,0.016816095,-0.0051963683,0.023411402,-0.06325957,-0.03491063,0.03475463,-0.06725965,0.025544005,-0.008708599,-0.018893594,-0.033820387,-0.016559953,-0.11610548,0.008871141,0.015627583,-0.047833353,0.053327996,-0.018705953,-0.035294846,-0.006622607,-0.033081565,0.023174569,0.04294896,-0.051270545,-0.03783899,-0.022496162,-0.06673883,-0.025402464,-0.048863802,-0.08212396,0.036432568,-0.043153465,-0.08105679,-0.010083891,-0.03490238,0.0037226563,0.029725688,-5.252378e-33,0.08378626,-0.08059799,0.07475897,-0.02934222,-0.010408157,0.0050087855,0.068789825,-0.08764741,0.033400122,-0.053107426,0.0007051531,-0.0602922,0.13019262,-0.01434126,-0.054061815,-0.014277229,0.02063787,0.065573625,-0.070828274,-0.052090228,-0.01818128,0.14695412,-0.019727198,-0.030061232,0.019061804,0.020262856,0.008772167,-0.011511789,0.05741382,0.08790168,0.07695532,-0.0963541,-0.011661972,0.0008189589,-0.064076595,0.01724954,-0.03889412,-0.087772354,0.0031553288,0.045185473,-0.02833811,-0.0028885722,0.09575741,0.07967062,0.008679914,0.007677591,-0.08569165,-0.012726335,0.018782392,-0.009344558,0.039111383,0.022222914,-0.06486823,-0.03210365,0.08447895,0.016578628,0.06517229,-0.101496376,-0.031648107,-0.10649341,-0.056417245,0.005894708,0.032845918,-0.06243229,0.07024451,0.03988501,-0.04336575,0.071246386,0.07374597,-0.035768885,0.033491198,0.090225264,-0.04183347,0.040254917,0.059232876,-0.032076146,-0.045435205,0.044667974,-0.0016410153,-0.022312412,-0.027914729,0.012749048,0.03678792,-0.045627143,0.027612472,-0.04905113,0.016425816,0.08664871,-0.0004274622,0.009530623,-0.07060364,-0.012781351,0.018077075,-0.02207901,0.0880853,-3.111377e-08,0.062939584,-0.010220771,-0.032337595,-0.015419711,-0.083761,0.03408141,-0.01678854,-0.033084214,0.018839242,-0.03803915,-0.05258673,0.07779117,0.057092242,0.04782442,-0.03437015,-0.022478335,0.011532971,-0.09294137,-0.049649224,-0.09440697,-0.06828582,0.0030305318,-0.022471234,0.1026987,0.06270566,0.040151794,-0.0075782035,0.018548202,-0.022326633,0.00611871,0.010923817,0.026852192,-0.03738555,0.0819514,0.041067217,0.108695716,0.04279884,-0.018673548,-0.014676237,0.018127127,0.07338431,-0.098937854,-0.12173186,0.018083751,-0.10266773,0.00095449906,0.04248578,0.013570611,0.0021059578,0.085843176,0.050088666,-0.01748829,-0.02926164,-0.034451008,-0.062332027,0.05575704,-0.0211077,0.057097852,0.09194538,-0.041740377,0.0777715,0.024187807,0.07760399,-0.11984068 +2.3.1.123,"Other acyl-CoAs can also act, but more slowly. alpha-Saturated dolichols are acylated more rapidly than the alpha-unsaturated analogues.",384,1.0,-0.014889731,-0.18372239,-0.05883074,0.014846385,0.006369335,0.010942218,-0.10969445,0.0736698,0.06645641,-0.035531063,0.038636435,0.03161406,-0.07472745,0.09299244,0.06507918,0.04914283,0.08691086,0.017815499,-0.03740482,-0.030445553,-0.07891266,-0.008289503,-0.01908377,-0.0055272183,0.020782229,-0.016852738,-0.033459116,-0.057896636,0.052996807,-0.06749647,-0.0043668686,-0.007515843,0.013190167,0.00041484903,-0.019871442,0.012980131,-0.06916906,-0.054645006,-0.010522349,0.018463766,0.037426006,-0.07436932,0.0010920236,0.01449315,-0.082057565,-0.07968982,-0.024499116,0.009689755,-0.0543947,0.05916446,-0.08934888,-0.057467345,-0.039729994,0.031051137,-0.026051547,0.04355838,-0.07207919,0.042110294,-0.022513442,0.065301456,-0.0625936,0.010438891,-0.05559837,0.07232005,-0.032757606,0.06917128,0.06011606,-0.036242515,0.02799217,0.030723564,-0.00897137,-0.035938248,0.03474726,0.020474378,0.0604312,-0.06516668,0.030623432,-0.020262862,0.07756695,0.016838996,-0.0060281903,-0.022730282,-0.0457916,0.04078052,-0.058900148,0.043913033,-0.037521526,-0.034945887,-0.027507989,-0.013421694,0.07162568,0.07068858,-0.02789395,-4.4228924e-05,-0.0070914957,0.046405606,0.0805483,0.0039982684,-0.015368865,0.017946588,-0.027858138,0.0440256,-0.08058582,-0.027484497,-0.1111243,-0.0845215,-0.013742786,0.009235412,-0.07698246,0.09424511,0.028324349,-0.041191794,0.1134121,-0.017633224,-0.06090226,-0.005589378,0.0002562499,0.009911338,-0.03576603,-0.041801732,-0.003767614,-0.01881777,-0.010389932,0.087228075,0.033419244,0.0070581404,-0.006061038,1.2405185e-33,0.08449797,0.01149658,-0.012081257,0.02964526,-0.06882372,-0.05015224,-0.054893747,0.038367935,-0.079338655,0.034039848,0.06598992,-0.035718147,-0.021683736,0.06673894,0.0180868,-0.08994599,0.045036275,0.061351575,0.0030635537,0.017905943,0.05625707,0.062280558,0.031973872,0.024052115,-0.0019037353,-0.025815716,-0.040174726,0.06754318,-0.03901772,0.0061940714,-0.004272457,0.002862058,-0.08071907,0.06315105,-0.045190956,0.048385877,-0.10607285,0.0035331706,0.013951141,-0.0036226858,0.043544833,0.08078234,-0.07027956,-0.030111477,0.14776596,-0.060691528,-0.05132618,0.043242924,-0.03199616,0.056127563,0.0940314,0.037263192,0.011416704,0.038814932,-0.008724999,0.038326405,-0.0052938038,0.032257657,-0.008458724,-0.0036604416,-0.021506391,0.028588172,-0.022785023,-0.010060157,-0.05960316,0.03674904,-0.07438995,-0.023925966,-0.02455227,0.002329792,0.08958741,0.019560838,0.02501311,-0.013070681,0.043410618,-0.06715374,-0.010672959,0.088208325,0.05851914,-0.050860062,0.06687611,-0.018056754,0.03641219,0.09519906,-0.029668907,-0.040510714,0.015332258,0.005935718,-0.018191095,0.027188111,0.009130646,-0.03271527,-0.055888105,0.024195656,0.08784783,-1.9927179e-33,0.11312435,-0.13363048,-0.01849454,-0.0005932811,-0.038470425,0.04788556,0.0037476893,0.02435863,0.08107561,-0.046231307,0.08551683,0.07357469,-0.08928357,-0.101420626,0.035245154,0.008561721,0.09440766,0.07628391,0.026767492,-0.0118531,-0.024546273,0.027490642,0.047433045,0.014601632,0.059705604,-0.017659022,0.058323096,0.051731948,-0.010350936,0.0416267,0.034411516,0.021406049,-0.053803965,-0.09576219,-0.0019823348,0.049614884,-0.05252151,0.0957935,-0.081073746,-0.06106596,-0.043651722,0.0043954826,0.05298134,-0.028063612,0.013966305,0.0460583,-0.021580324,-0.09213163,-0.017778277,0.02317779,0.00012668627,-0.055556376,-0.02819949,-0.013685134,0.0022410653,0.07128902,-0.0110361185,-0.07977624,0.016138114,-0.097400434,-0.054851044,0.077341236,-0.017906649,-0.035197433,0.025225714,0.0003553337,-0.05358959,-0.026541524,0.09198668,-0.04103772,0.057077263,0.04003906,-0.010273029,0.010150994,-0.003761292,-0.07417406,0.03834267,-0.064496666,-0.037632596,-0.035286047,-0.069524504,0.059921287,-0.017960634,-0.019756613,-0.05663922,0.034202155,0.0138095645,-0.042565465,0.018175403,0.0930356,0.009334965,0.059116386,0.073030405,-0.015035643,0.10366337,-3.1262278e-08,0.055234488,-0.040174335,-0.018511066,0.007787421,-0.018425843,0.0246906,-0.01586615,-0.008026515,0.005852202,-0.036154125,-0.028270895,0.08522021,0.075601354,0.045172308,0.01273525,-0.043314446,-0.036006376,-0.09598482,-0.058834642,-0.022877527,-0.07811726,0.009239867,0.06709827,0.0036472639,-0.017634587,-0.03480335,-0.004062192,-0.04987956,-0.011540744,0.02604162,-0.041556068,0.016970307,-0.00051753706,0.018944219,0.07016736,-0.00019454102,0.09375342,-0.0187268,-0.087780036,0.08427634,0.0052994434,-0.08619013,0.019608041,0.034305274,-0.027656332,-0.06282943,-0.043969817,-0.007443118,0.08173474,0.008493262,0.06295658,0.061456736,-0.11963331,-0.06428818,-0.054716967,-0.019251514,-0.0024592164,-0.042301536,-0.00635712,-0.022998903,0.027416615,-0.0447911,0.11116649,-0.035000034 +2.3.1.125,A number of acyl-CoAs can act as acyl donor; maximum activity is obtained with linoleoyl-CoA. Not identical with EC 2.3.1.20 diacylglycerol O-acyltransferase.,384,0.99999994,-0.0882764,-0.07962595,-0.08549199,0.009686538,0.048858155,0.021210989,-0.057055317,0.050270874,0.055956706,-0.08607447,0.07873298,-0.062079478,-0.066545516,0.04672124,0.036030527,0.06640571,-0.014197124,-0.015680086,-0.08074433,-0.04500923,0.012233186,0.00822439,0.044594765,0.0030223795,0.039196603,-0.09468306,-0.0093564,-0.031412065,0.030268172,-0.10909697,0.013111792,-0.07810729,0.013255002,-0.034815025,0.08559981,-0.047915667,-0.011022017,-0.031872954,-0.011887433,0.06931689,0.07406664,-0.119058125,-0.032867797,0.030316023,-0.03954478,-0.05695818,-0.006256076,0.0067612967,0.036827516,0.041741587,-0.0069810282,0.0034835767,-0.07787232,0.031433187,-0.026198884,0.08167713,-0.043626584,-0.03577236,-0.051408187,-0.0010269163,0.025757747,0.01492824,0.00805981,0.03465913,-0.11361293,-0.03296441,0.07293595,-0.08192708,0.085812904,-0.021090413,-0.06405642,-0.08963094,0.044655178,0.07015579,0.07295052,0.005288429,-0.02581902,-0.028932892,0.05808291,-0.017950602,-0.030179229,-0.015413442,-0.00045265086,0.017301958,0.017077586,-0.021172721,-0.034581386,-0.005892347,-0.03459305,0.01835876,0.016176613,-0.030277489,0.04520076,0.032583624,-0.0530396,0.051313892,0.09513105,0.015376299,0.043951675,-0.0041892827,-0.049275856,0.07481729,0.02627066,-0.044322915,-0.064963885,-0.04569584,-0.032347742,-0.007079154,0.0041499417,-0.0012641816,0.021469178,-0.07597116,0.097222425,0.01041597,0.0014577969,0.032504205,-0.08279304,-0.028394857,-0.0046770866,0.041743796,0.0123891,-0.06231354,0.05049669,0.08691318,-0.0036754285,0.10812656,0.0009763212,3.4362462e-33,0.049949512,0.06928459,0.014908799,0.0218141,-0.07824967,-0.055465348,-0.091763414,0.051709943,-0.039771825,-0.039947752,0.016252544,-0.030449696,0.05214953,0.1134677,-0.0066128154,0.002757526,0.023768328,-0.02528307,0.07947951,0.001649491,0.020202087,0.019631026,0.023372559,0.024537329,0.04707903,0.0112288585,-0.015245118,0.07577113,0.032988433,0.0294415,0.012621216,-0.06984706,0.03867083,0.012611822,-0.0128511805,0.016030936,-0.011237726,-0.03693837,-0.005332042,0.05657728,0.04386366,0.048459906,0.0042913915,-0.044114202,0.08590262,-0.023787808,-0.05673711,0.099638626,-0.0051177996,0.03841974,0.008031741,-0.02546964,0.0614535,0.07990711,0.01696309,-0.0042189793,-0.107666574,0.019771285,0.04802362,-0.06275675,0.031367637,0.08106543,0.03668269,-0.0036503088,-0.035547,0.02499106,-0.08710206,0.0018557303,-0.100931026,0.007970872,0.034953833,0.0060290834,0.0061096344,0.026893005,0.08813208,-0.037406337,-0.008498688,0.068727195,0.07159016,0.009005864,-0.024420027,0.038706683,0.10667753,-0.0364673,-0.021490345,-0.028821444,-0.051497772,-0.02233443,0.032881666,0.023114817,-0.04319091,0.008482728,-0.008947267,-0.0041138367,0.067928165,-3.657512e-33,0.10166742,-0.062311247,0.01324008,-0.107552975,-0.010639464,0.023229636,-0.003755257,-0.014662761,0.10317394,0.03979635,0.096272,0.03356226,0.054583613,-0.12308254,0.061881833,-0.017550137,-0.054390732,0.021425042,0.0029935094,0.02654205,-0.029479966,-0.047383502,0.005484431,0.021008527,0.07068299,0.03749035,-0.10639005,-0.03240181,0.023932401,0.047688328,0.04909255,0.017673017,-0.06313347,-0.016244195,-0.03625188,0.006003658,-0.03881542,0.07609262,-0.04252994,0.016799444,-0.036584273,-0.019719562,0.076584905,-0.055715043,0.04562783,0.024792662,-0.009222143,-0.0729707,0.022303063,-0.115049735,-0.01742797,0.009219784,-0.006031032,0.0132670235,0.031771507,0.1577571,0.056355838,-0.028051224,0.046444006,-0.19263747,-0.049255524,-0.027462663,0.0065237833,-0.017579328,0.04509077,0.03245362,-0.044979136,0.041347165,-0.0036204108,-0.017339787,0.024593301,0.037978828,-0.025001682,-0.024815459,-0.045451205,-0.031571902,-0.029863048,-0.06514882,-0.06372748,-0.045639776,-0.083686285,-0.056867972,0.011951977,-0.058162153,-0.08915819,0.018268637,-0.0076744333,-0.0026937372,0.008982404,0.043270297,-0.056338526,-0.045926277,-0.044195175,0.02135569,0.028345233,-3.465654e-08,0.024277747,-0.014836144,0.0068416703,-0.019760123,0.022069946,0.018568369,-0.08202176,0.0346802,0.04648562,-0.014137896,-0.03047896,0.0916339,0.086104885,0.023911709,0.0033537976,-0.032508783,0.042274807,0.0010500675,0.00071017205,-0.103530206,-0.057502292,-0.00891141,0.044889156,0.04944198,-0.029933235,-0.040369812,0.040902976,-0.014206993,-0.034850083,-0.011773729,-0.009376011,-0.004774807,-0.03471255,0.060186483,0.069577694,-0.014033773,0.077635214,-0.057230733,-0.086361825,0.13491237,0.02271296,-0.02792595,-0.06272619,0.057999182,0.121407285,-0.054959286,0.024543017,-0.02650388,-0.038467143,-0.026243515,0.015327239,-0.037846323,-0.07568571,-0.036565844,-0.047192555,-0.014802324,-0.054284032,-0.016878104,-0.008237934,-0.01745982,-0.0353887,0.009479782,0.14525272,-0.009015034 +2.3.1.126,Feruloyl-CoA and 4-coumaroyl-CoA can also act as donors.,384,0.99999994,-0.0477834,-0.01506995,-0.09337875,-0.010063755,0.07910344,0.021446446,-0.026001433,0.04608819,0.009788172,-0.04358686,0.017708244,-0.08227862,-0.08699229,0.09689266,-0.013644723,-0.044905044,-0.015838612,0.017316818,-0.015875421,0.039153658,-0.00052235,-0.019366512,0.01424728,-0.0055394066,-0.006169408,0.029097885,-0.023620095,-0.046992894,0.05561263,-0.06527929,-0.03148574,0.018153125,-0.038265295,-0.013740433,0.0064128377,0.059087068,-0.006961857,-0.029995466,-0.026450118,0.05895204,0.003444243,-0.089294,0.030079754,0.01960638,-0.11361725,-0.07861329,0.044018965,0.0088094985,0.04930038,0.04221846,0.0008178106,0.0043888576,-0.09401447,0.09377919,-0.0005566363,0.031882502,-0.05658634,-0.05220325,-0.0023280121,0.042847387,0.012918221,0.015810292,-0.01706106,0.03462457,0.026350498,0.044254705,0.07915878,-0.0021628707,0.01606074,-0.0332705,0.07079912,-0.02105679,0.049892433,0.00708759,0.026450597,0.08910082,0.001143062,-0.02565565,0.042934883,0.035243973,-0.045545932,0.07643412,0.039213452,0.012679403,0.02188331,0.04751024,-0.07471713,-0.06673104,-0.04646719,0.025931766,-0.02098569,0.042571675,0.043044254,-0.031010427,-0.12377123,0.062617585,0.068838604,-0.0010702916,0.015389235,-0.0028333627,-0.06579619,0.07865106,-0.00672861,-0.03768778,-0.045085616,-0.07808741,-0.022667391,0.044253387,0.0029612116,0.025519961,-0.015339802,0.014041171,0.06156123,-0.0090999035,0.0052993875,0.074919485,-0.07048338,-0.05026609,-0.058837194,0.032950617,0.034074947,-0.00034211623,0.03768799,-0.015169344,0.01856674,-0.0059584775,-0.06735114,3.7338738e-34,0.07025908,0.0541229,0.07779385,0.11716362,-0.056055587,-0.019650107,-0.05153487,-0.023848124,-0.059049513,-0.027528422,-0.031767327,-0.025907913,0.07796141,0.05568982,-0.07044328,-0.058267597,-0.057904996,-0.07097182,0.07517473,0.04873943,0.068775155,0.10655797,0.039251782,0.06933387,0.028473165,0.024610927,-0.07696372,0.10029917,0.06448416,0.051112298,-0.020860922,-0.012774926,-0.007911433,-0.06590391,-0.004181712,-0.031872623,-0.07431445,-0.051863488,-0.090919636,0.044135015,0.0557473,0.009612689,-0.07281105,-0.023468358,0.10360412,-0.08825643,-0.03061755,-0.014257122,-0.10811454,0.05096288,0.025693042,-0.023559237,-0.0002187773,-0.008434254,-0.063775785,-0.017579608,-0.019456433,-0.021296926,-0.015387375,-0.007012507,0.06513206,0.06052442,0.011291631,0.052132104,0.011795386,-0.00091365835,0.0025104398,-0.053835172,-0.05380972,0.015676416,-0.00689878,-0.011509808,-0.006310132,0.06707491,0.069618195,-0.03055278,0.00083792815,0.03266653,0.116287805,0.008624883,0.004766372,-0.043140393,0.09231439,0.030973794,-0.022134066,-0.033210393,-0.01293995,-0.07824632,-0.0026036913,-0.079638086,0.049613953,-0.05581562,0.04853488,-0.12193211,0.0067906026,-1.5766783e-33,0.11012138,-0.1025836,0.0055074827,-0.07634895,-0.048910648,0.045047704,0.02457545,-0.11449713,0.091018535,0.062606245,0.10648104,0.022468273,0.041928895,-0.055300064,0.048673313,0.019446671,-0.0023660408,-0.06933482,-0.011597106,-0.018748315,-0.027957728,0.060761083,0.060778406,-0.04984735,0.066797994,0.04005823,-0.035946302,-0.04862894,0.029759979,0.037818592,0.026878767,-0.029642027,-0.05787255,-0.089480326,-0.048443414,-0.0012807556,0.011483864,0.005611658,0.013349066,-0.100388855,-0.044675916,-0.0182546,0.10128395,0.04224735,-0.027276155,-0.04924966,-0.009610913,-0.03417399,0.055610042,-0.020532312,-0.04925687,0.007471982,-0.09536921,-0.035805777,-0.0052388157,0.030716952,0.07311001,-0.05466136,0.047614425,-0.032172304,-0.07384153,-0.009907771,0.032293037,0.036967106,0.075600676,0.02658064,0.018811611,0.034951698,0.0425116,0.0013500472,0.087983444,-0.009735845,0.043298513,0.023474587,0.0042757946,-0.052246813,-0.036030408,-0.0027916266,-0.058389,-0.008723975,-0.08966606,-0.08198767,0.0094602015,-0.0067578307,-0.016812464,-0.14046738,0.05165816,0.026843453,0.018464098,0.018382128,-0.06711135,-0.024134545,0.0730162,0.05821,0.09062215,-2.6297267e-08,0.0019669696,0.010786829,-0.047941066,-0.036682017,0.031644315,0.019460661,-0.114666045,-0.04456576,0.048120175,0.037011042,-0.008960441,0.14676781,0.0444722,0.028861454,0.025631394,-0.040815506,-0.01569932,-0.041228425,-0.038848296,-0.10206397,-0.10555921,-0.028505333,0.013447418,0.044769645,-0.0144316275,-0.021818692,0.063122205,-0.014075467,0.013339091,0.0076824194,-0.015598395,0.029846206,-0.051796563,0.004508541,0.013751857,0.018940872,0.058827892,-0.0014166771,-0.08341857,0.08684046,0.032937616,-0.020977793,-0.07366573,0.046526022,0.025271153,0.03527374,-0.024746303,0.039470017,-0.011781966,-0.018774997,-0.004405437,-0.008223491,-0.046372756,0.005999544,-0.047519192,0.050876856,0.018316872,0.003547445,0.1181246,-0.07410781,-0.023024809,-0.022068761,0.118123285,-0.023327058 +2.3.1.128,"A group of enzymes in Escherichia coli that acetylate the N-terminal alanine residues of specific ribosomal proteins. cf. EC 2.3.1.88, peptide alpha-N-acetyltransferase.",384,1.0,0.02501848,-0.079943575,-0.116193645,-0.032976486,0.016148984,0.079942316,-0.017566537,0.015544171,0.090539046,-0.043537896,0.015742986,0.01434976,-0.035082724,0.071857914,-0.04179828,-0.019305874,-0.092844896,0.052533194,-0.019326828,-0.0942924,0.042777542,0.08295615,-0.024771683,-0.02302991,0.005469179,0.014968611,0.027687848,-0.009201495,0.005484078,-0.06709253,-0.018384343,-0.08479228,0.06544602,0.0058644866,0.11654151,0.033400416,0.010024632,-0.04764954,0.10488323,-0.007855214,0.026844086,0.057478905,0.038578637,-0.018521728,0.015300004,0.004704674,-0.016806513,0.065404676,0.048001565,0.010593617,-0.017005695,-0.07926123,0.009048387,-0.005069087,0.04259201,0.0435697,-0.05252972,-0.16307876,0.007896719,0.03416625,0.03615231,-0.013434782,0.009859683,-0.029055571,0.00536187,-0.048723437,0.071106315,-0.04706123,-0.0005356305,0.0017270276,-0.05561023,-0.08884822,-0.077645525,0.043184854,0.009048842,-0.068295605,-0.03135824,0.007121535,-0.008452401,-0.02552826,0.03170922,-0.055039797,-0.021159317,0.03908882,-0.021116074,0.023736382,-0.027600678,0.031275637,0.05858539,0.053566195,-0.053106602,-0.07129509,0.15911394,-0.06811724,-0.0031305475,-0.04050613,0.0062617497,0.025082547,-0.003441646,-0.01094441,-0.0034287523,0.07051493,0.0021694067,-0.0034105338,-0.04997447,0.015727729,0.021252317,0.098346524,-0.015446504,-0.0079403175,0.017616661,-0.015178507,0.03189791,-0.021641122,0.0139185935,0.032993373,0.009299411,-0.061164487,0.000599067,0.0036462778,0.026748823,0.0153321605,0.06080311,0.11547393,-0.00094945444,0.073566064,-0.09261955,-2.177988e-34,0.060127012,0.046553295,0.06994768,0.012520361,0.0013546167,-0.050470207,-0.053901877,-0.014493543,0.053849712,-0.023704091,-0.0700638,-0.069555186,0.049589977,-0.05586454,0.04600547,0.018414376,-0.02211096,0.03145803,0.021560473,0.040639542,-0.042200103,0.020756282,0.02806761,0.040145658,0.040072944,-0.018851023,-0.016670045,-0.027997065,0.08922612,-0.0019305297,-0.045599636,0.017591126,-0.09594664,0.06984592,0.022237651,-0.06318881,0.03269932,-0.020580458,0.07161824,0.065849766,0.0020771343,0.047135733,3.522294e-05,-0.037336476,0.050114725,-0.04879095,0.01138757,0.057802957,-0.037972473,0.061917674,0.023540696,-0.009690142,0.08533216,-0.079199106,-0.014712321,0.013074903,-0.048675064,0.0761397,0.01146499,0.060148202,-0.008545529,0.01353549,-0.0044626407,0.019973932,-0.034664717,0.002927197,-0.0032580453,-0.12296164,0.024542889,0.109636545,-0.07877445,-0.033151343,0.09916317,0.039557755,0.012872553,-0.04103463,-0.15375112,0.014348967,-0.01587805,0.016960463,-0.048775993,0.059724472,-0.033482183,-0.048887245,0.013422949,0.008860832,0.07383524,-0.06957886,-0.012475239,-0.029851293,0.055427674,0.0021390896,-0.046446316,0.08438202,0.031279124,-1.2708953e-33,0.097200625,-0.13583964,0.0042972174,-0.048653178,-0.15597387,0.034846965,-0.038125057,-0.0076546893,0.015258245,-0.027482172,0.031796537,0.008407885,0.021984031,-0.085845105,0.0673154,-0.109970324,0.02341698,0.070511684,0.028824082,-0.009269392,0.018357227,-0.020020444,0.007905811,-0.012370815,0.0015096321,-0.0007965015,-0.023945132,0.08993479,0.03532084,-0.0048518153,-0.03342273,0.0077580614,0.011476341,-0.036678534,-0.12140411,0.09308307,0.026974719,0.059763115,-0.008689074,0.00047078205,-0.0137372725,0.08004112,0.0031200864,0.06581796,-0.041046757,0.044341758,0.011424901,-0.0027553232,-0.030355537,-0.08665114,0.02505449,-0.05947116,0.0064422423,-0.021695461,-0.035104696,0.041814424,0.011833613,0.08897178,0.024860315,-0.00592445,-0.02284346,-0.019712778,-0.0008519896,0.02004708,0.052190024,-0.005777869,-0.034306712,0.005069444,0.049196556,0.011631537,-0.0018707038,-0.017688908,0.04371646,0.08961411,0.09700975,-0.048720904,-0.09627986,-0.10206063,-0.021731384,-0.07037409,-0.09959244,-0.0008024447,-0.035282727,0.041560557,0.0071001514,-0.08225592,0.07727104,0.119069494,-0.022444846,0.04428805,0.0018187672,-0.031012483,-0.020255791,0.03348551,0.00057184335,-3.0279452e-08,0.09224773,0.010320057,-0.026581157,-0.07207473,0.018966142,0.034802124,-0.05133881,0.01482674,0.05723878,-0.0025940093,-0.033371907,0.066362455,-0.004877778,0.018281167,-0.022412194,0.06503962,-0.032058854,0.0058579063,0.011789527,-0.011446127,-0.011013379,0.0549912,-0.04167352,-0.037307166,-0.022787511,-0.045265313,0.013642898,0.04551439,-0.01365421,-0.034713566,-0.05761202,-0.013982575,0.036797363,-0.10029454,-0.043780155,-0.022298384,0.019709943,-0.07382605,0.04957659,-0.009971659,0.040593125,-0.050182883,-0.14267433,-0.016149428,-0.026292302,0.044250634,-0.029241629,0.009081312,-0.055298477,-0.031347755,0.07194914,0.009377429,0.01977016,-0.035487615,-0.09755854,-0.023024322,-0.030856077,-0.12768854,0.06974133,-0.012014975,0.029119015,0.03574519,0.09493304,-0.063859686 +2.3.1.129,"Involved with EC 2.4.1.182, lipid-A-disaccharide synthase, and EC 2.7.1.130, tetraacyldisaccharide 4'-kinase, in the biosynthesis of the phosphorylated glycolipid, Lipid A, in the outer membrane of Gram-negative bacteria.",384,0.9999999,-0.079552084,-0.0051496574,-0.112129465,-0.0028459118,-0.04093245,0.018460942,-0.07053732,0.033041526,0.10933382,0.011494357,0.07496702,-0.1036408,-0.034741145,-0.024737023,-0.06324051,-0.05440243,-0.01659663,0.028432997,-0.051647898,-0.07124151,0.033412717,0.028346749,-0.045687728,-0.045453746,-0.022483233,0.00010876804,0.01594278,-0.033228733,-0.02195583,-0.06523799,0.017309403,-0.05886532,0.08115906,-0.080925405,0.04910405,0.092752144,0.022956727,-0.025958389,0.11086269,-0.0033272319,0.030740742,-0.039127044,0.016956111,-0.026083333,0.007900688,0.023025827,0.03954297,0.073549904,0.05520175,-0.044053275,-0.0026630422,0.0033291432,-0.05555085,0.015217772,-0.0071559018,0.024209712,-0.040414464,0.030465875,0.022492124,0.046968207,0.045281265,-0.0026228067,0.123113476,0.05118947,-0.06825277,-0.096701264,0.062551714,-0.05931369,-0.011115896,0.01235938,-0.10735007,-0.01912639,0.050652277,0.022818197,0.028050156,0.0850376,-0.01106818,-0.050228115,0.009809369,-0.051621888,0.08175024,-0.079146795,-0.0144432485,0.06773146,-0.030667733,-0.14536265,0.036903407,-0.046150032,0.029082902,0.08005657,0.03219414,-0.052297235,0.081017226,0.0031367615,-0.08092902,0.022292556,-0.0038593754,0.06121811,0.005656615,-0.0628956,-0.063635,0.01326509,-0.008516666,-0.010251018,0.028312057,0.0025074824,0.020058991,0.06608742,0.023617998,-0.006408465,0.036274217,-0.006049349,0.037841834,-0.033123568,-0.00027184247,0.047592465,0.004304819,-0.084100366,-0.015526041,0.02570155,-0.02695034,-0.052322477,0.028414227,0.03671277,-0.028438998,0.0857232,-0.041237388,1.0726618e-33,0.074399605,0.041354124,0.062334973,-0.022067765,-0.0044229697,-0.049890954,-0.07196798,-0.05455858,-0.039711654,-0.04702696,-0.0038218156,-0.12515913,0.036097135,0.092301704,-0.0049744155,0.027184432,-0.009934193,-0.029435689,0.015849967,0.02586995,-0.05220949,0.029191563,0.030251099,-0.06672781,0.116233155,0.06873485,-0.021558965,-0.06537663,0.062254526,0.021462832,-0.029994853,-0.04679155,-0.073601775,0.03180662,0.09062121,-0.018810654,-0.042380396,-0.0037976333,0.016830606,8.591909e-05,-0.028624142,0.054719143,-0.01916896,-0.056353893,0.007404908,0.030939236,-0.014374118,0.060894646,0.09298394,0.016039504,0.031727914,-0.021934178,0.07429413,0.026619505,0.006533467,-0.06307444,-0.05681837,0.03530328,0.017017765,0.03734982,-0.0055156616,0.1154898,-0.113237426,0.013896909,0.014098523,0.037089393,-0.059813883,-0.08176396,-0.019591121,-0.0110365255,-0.021226253,-0.04185296,0.104099184,0.046281878,0.0045876536,-0.0056118867,-0.026794497,-0.016452434,-0.018141642,0.01211326,-0.009253281,0.035955973,0.013409591,-0.06993164,-0.049987927,0.016732914,-0.061552946,-0.0147873815,0.047634657,0.043199673,-0.01159764,-0.014264042,-0.10897337,0.10033337,-0.058149017,-3.720174e-33,0.035838902,-0.021791661,0.0217814,-0.051446445,-0.060844097,0.05900549,-0.05269692,0.021445988,0.055653736,0.027274707,0.060103666,9.857746e-05,0.020571189,-0.022816405,0.008250825,-0.05795508,-0.026634239,0.04266093,-0.049401376,-0.04728989,0.037246972,-0.005416828,0.0055548465,0.033776954,0.035937533,0.007362544,-0.058945704,0.08635295,-0.062057577,-0.0068272315,-0.024646513,-0.010497192,-0.06604114,-0.0155333,-0.07580896,-0.033559784,-0.093627095,-0.012327261,0.039039757,-0.015845066,0.025812676,0.06190757,0.084154285,0.022297086,0.032419894,0.073170386,-0.018487537,0.085770905,0.011828625,-0.044322465,-0.067598626,0.0046796193,0.018633155,0.08610458,0.029188968,0.04309059,0.05247086,0.08688355,0.04164262,-0.054239333,-0.07347106,-0.116486914,0.10690001,-0.068093725,0.069545165,0.059302796,-0.020208769,0.05151166,0.07316254,0.013436052,0.06672612,0.025466437,-0.07179345,-0.017311359,0.014093136,0.030026324,-0.109140255,-0.11622142,-0.00693504,-0.02277361,-0.031067237,0.062506065,0.035777267,-0.082624696,0.041409682,0.028112005,0.043780267,0.05920998,-0.02061347,0.06913416,-0.020695852,-0.049772102,-0.07192522,0.050275985,0.04780754,-3.8143938e-08,0.040873695,-0.0025477342,0.02475428,-0.04903368,0.0320197,0.027948737,0.017674902,0.08337533,0.04152499,-0.010039176,-0.0030001998,0.0701298,0.026950276,-0.01932148,-0.023294877,0.096772015,-0.07314996,-0.022360153,0.011787738,-0.023343394,-0.000863425,-0.0958201,-0.11971612,0.08007433,0.029689511,-0.08875973,0.029440634,-0.02855418,-0.06417763,-0.056916993,0.0047209747,0.005108625,-0.024852697,-0.033248052,-0.0018850239,-0.05320722,-0.09913627,-0.06035049,-0.041252747,0.04418869,0.035859622,0.021622693,-0.051531587,0.013818408,-0.01022479,0.048169326,-0.018610707,0.038243305,-0.10132712,-0.015014266,-0.0010803944,-0.028154433,-0.01024563,-0.03403676,-0.090276904,-0.039000817,-0.040037174,-0.011997381,0.016278805,0.008257707,0.020646457,0.01750773,0.094012186,0.019819427 +2.3.1.130,Sinapoyl-CoA and 4-coumaroyl-CoA can also act as donors.,384,0.99999994,-0.096963555,0.027791463,-0.073304035,-0.05841723,0.03294306,0.024954978,-0.022992352,0.05100435,0.011609324,-0.027160414,0.04696557,-0.09950802,-0.059984595,0.065446265,0.007853041,-0.023217604,0.02095714,0.029533563,0.013825574,0.0050597847,-0.019466978,0.029532103,-0.00937135,-0.023557423,0.0033569008,0.061340947,-0.052035786,-0.037175756,0.07011113,-0.04993554,-0.022295894,0.03652397,-0.05570103,-0.015140881,-0.015148572,0.05402174,-0.028600883,-0.0044256104,-0.024679791,0.12711602,0.03735688,-0.05188658,0.028054733,-0.03487492,-0.12269469,-0.065041,-0.0055848407,0.018099507,0.055125896,0.06107763,0.017052881,-0.00038492354,-0.10027052,0.04834064,-0.044987056,0.011745024,-0.08131994,-0.04862422,-0.022682345,0.05614488,0.055098485,0.030695092,-0.0052828765,0.026685247,0.017901514,0.061339132,0.068594076,0.00888786,0.03811507,-0.049760815,0.036890235,-0.047461934,0.043346863,0.031082863,0.008637226,0.052375764,0.0023173639,-0.011613672,0.03755348,0.0071014217,-0.09198933,0.08988272,0.032347087,0.028268645,0.016003612,0.10361421,-0.08017932,-0.034245793,-0.016548181,0.033368904,0.002402447,0.045084935,0.029188087,-0.038000736,-0.08009574,0.03987972,0.037611615,0.0017660998,-0.057612576,-0.004750739,-0.046554323,0.056706138,-0.013190021,-0.0657045,-0.0075793425,-0.08540453,-0.006402221,-0.031441875,0.03543964,0.0021033417,-0.033157207,0.041595366,0.03937484,-0.001472666,0.01311885,0.1016785,-0.10210951,-0.036940794,-0.017024582,0.03909204,0.043820776,-0.022444794,0.029333198,-0.016220877,0.029524868,-0.041817125,-0.047909517,2.5179022e-34,0.024158048,0.080129154,0.07214082,0.11080049,-0.053239435,-0.026225487,-0.033072885,-0.007137841,-0.058050252,-0.0367097,-0.030448087,0.018058488,0.042928085,0.10403336,-0.066138186,-0.0702752,-0.06544147,-0.03713864,0.026384735,0.008416018,0.06484298,0.063798584,0.045261595,0.084321216,0.03430747,0.0048864186,-0.050650444,0.08440738,0.087327875,0.05068256,-0.017850483,-0.009235655,0.041553646,-0.063186176,-0.02816003,-0.026073372,-0.07348095,-0.057993717,-0.10581428,0.060284488,0.057528794,-0.0007714093,-0.03638212,0.033770066,0.08193074,-0.08994476,-0.024522772,-0.03718464,-0.07671546,0.019827513,0.013530052,-0.010404042,0.040940236,-0.027617436,-0.059656814,-0.034826595,-0.024074696,-0.030094286,-0.041100364,-0.035704162,0.03449931,0.018365039,-0.0002507783,0.03832144,-0.008389667,0.032423776,0.029107902,-0.124887705,-0.034110576,-0.029354278,0.038722456,-0.01399517,-0.026609166,0.091227844,0.027223531,-0.02607576,0.044764012,0.091749735,0.08830392,0.00184666,0.007845736,-0.016556563,0.10005074,0.00051541656,0.02984273,-0.032895252,0.05619062,-0.115715325,0.0017637879,-0.06024026,0.023603436,0.002509398,0.022753745,-0.11787199,0.009185775,-1.4514303e-33,0.048291616,-0.075866215,-0.0019957777,-0.081002444,-0.049106125,0.044072054,0.060100794,-0.09751276,0.093093164,0.043736268,0.08357954,-0.00079538627,0.03699538,-0.03352876,0.068041205,0.011995731,-0.0007179609,-0.09143017,-0.018707294,-0.017011877,-0.008289809,0.0645145,0.08801511,-0.0244154,0.055158906,0.033920087,-0.038791955,-0.064529344,0.019453013,0.015741672,0.016254613,-0.02197119,-0.056138854,-0.046653222,-0.07515703,0.025188575,0.024251623,0.025801092,-0.048738215,-0.12204163,-0.02210013,-0.07288866,0.09600207,0.046945374,-0.043724954,-0.08356754,0.0033773468,-0.05640177,0.000730191,0.0012448491,-0.028376834,0.0030713375,-0.038745657,-0.006816366,0.0008375491,0.045172412,0.026865158,-0.07322408,0.03681434,-0.07529644,-0.040773343,-0.0054208166,-0.0134192975,0.038900115,0.10294271,0.02581492,0.044611666,-0.002998568,-0.010466832,-0.0026087957,0.06874187,-0.045114085,0.056064263,-0.057322074,-0.017217105,-0.0716978,-0.03656938,-0.0029249138,-0.072384275,-0.07251968,-0.11151441,-0.087588005,0.011035194,-5.739102e-05,-0.0309781,-0.120707355,0.0776272,0.013502606,0.026018556,0.07647303,-0.08138529,-0.019998813,0.04885683,0.08932929,0.10149282,-2.61665e-08,0.058474865,0.053207252,-0.052694425,-0.0045570876,0.02368061,0.010283659,-0.096530214,-0.026830848,0.032370105,0.06946105,-0.03286942,0.12503847,0.054271564,0.013257527,0.028863069,-0.04055101,-0.045499954,-0.0073850816,-0.020129992,-0.13791193,-0.046585523,-0.002027261,0.051800743,0.035788894,-0.016748229,0.023145512,0.074420914,0.012459336,0.009469091,0.027296126,-0.019062547,0.013128254,-0.040900577,0.0048908265,0.010051764,0.0330504,0.075972885,0.011361622,-0.05040463,0.08437056,0.0009251321,0.013506764,-0.060890656,0.062484607,0.020819988,-0.01804871,-0.011387587,0.017420223,0.04649013,-0.020180574,-0.030909771,0.011302629,-0.022747088,-0.041669175,-0.06935437,0.020106737,0.031926602,-0.00094630365,0.07137238,-0.018328464,-0.03539091,-0.0044043004,0.12377589,0.0015877235 +2.3.1.131,"4-Coumaroyl-CoA, feruloyl-CoA and caffeoyl-CoA can also act as donors, but more slowly.",384,1.0,-0.045012873,-0.040841028,-0.06767393,0.015982509,0.09316648,0.0050507183,-0.042926863,0.061651666,0.02744876,-0.0465961,0.021733938,-0.09461914,-0.064356595,0.08249034,-0.013975741,-0.048593525,0.008014745,0.00868301,-0.025347259,0.025683295,-0.021859042,-0.05076304,0.021779241,0.0062517785,0.022059362,0.04126525,-0.054303892,-0.07389967,0.065914266,-0.088382706,-0.046267614,0.042215984,-0.025661878,-0.007899224,-0.0028872932,0.07575908,0.004451877,-0.023462964,-0.014531079,0.09059459,0.011193351,-0.080053434,0.03403453,0.036605425,-0.07736093,-0.08960091,0.033809956,0.003637068,0.059794266,0.024831515,-0.015668524,-0.00019011908,-0.10377331,0.07509414,0.006090341,0.009439597,-0.045396432,-0.045296606,0.018258613,0.056069117,0.026681913,-0.012541853,0.00086638215,0.03784369,0.04585023,0.058181576,0.05891916,-0.019706782,0.046718538,-0.015014859,0.056384917,-0.00075194327,0.04799303,0.008782281,0.025757506,0.08147286,0.019634737,-0.004992895,0.03720968,0.004887315,-0.06345015,0.060596045,0.045047674,0.017071452,0.009299173,0.060999442,-0.047792602,-0.05798125,-0.07122127,0.035897054,0.0017060443,0.08091073,0.061365902,-0.008877378,-0.13233133,0.036591757,0.06335267,-0.012667426,-0.020814724,-0.0011487667,-0.061010357,0.07953884,-0.0047661094,-0.021648996,-0.03614677,-0.09369368,-0.043225013,0.015922893,0.016255401,0.03817862,-0.00948467,0.026326858,0.039122757,0.038590252,-0.002551176,0.07430396,-0.069470845,-0.048753597,-0.04224315,0.061004188,0.034271926,-0.010202248,0.012122328,-0.052301373,0.004175423,-0.01309767,-0.028910024,2.0134815e-33,0.065653704,0.027385533,0.080974914,0.099755876,-0.049675092,-0.020505002,-0.06051923,-0.0139092505,-0.051142722,-0.032296512,-0.03052918,-0.009369504,0.05978927,0.072332956,-0.059512865,-0.10561515,-0.053838875,-0.03844119,0.05477845,0.02037929,0.07945471,0.084888905,0.035792083,0.056659482,0.046571985,0.0032422715,-0.07392989,0.10109367,0.07007499,0.041856043,-0.045430996,-0.0031331351,0.009413098,-0.058181576,-0.040900543,-0.05527242,-0.022473698,-0.054823954,-0.060300715,0.07743495,0.0226816,0.0064624646,-0.061733454,-0.011354276,0.09782698,-0.09296238,-0.024494367,-0.017426109,-0.1364133,0.05768909,0.0061670667,-0.015366224,-0.0015000035,-0.001377696,-0.0511148,-0.017827002,-0.030426633,-0.026299406,-0.021970898,-0.0006022358,0.08096001,0.04889965,0.011287539,0.03451319,0.0056134975,0.024721853,-0.005735469,-0.05115031,-0.04100004,0.0061443667,-0.0013070618,-0.010772077,-0.019887846,0.028851606,0.08968935,-0.048248585,0.008241591,0.03784558,0.068583645,-0.010487245,-0.0043515493,-0.023994321,0.07086261,0.039958414,-0.008378503,-0.015551352,0.016583517,-0.08444416,-0.012391839,-0.06968473,-0.0019295125,-0.046784274,0.044282597,-0.11874409,-0.02053183,-1.960253e-33,0.12040998,-0.12354903,0.041401513,-0.050418608,-0.033610005,0.050843086,0.0307247,-0.091679715,0.092751294,0.046092592,0.12340094,0.026188193,0.057060905,-0.05148039,0.027798435,0.02697317,0.018896902,-0.06199516,-0.016139258,-0.016440969,-0.023217047,0.054825198,0.040779795,-0.04866062,0.058746602,0.050492942,-0.043044597,-0.05858071,-0.0104733175,0.03326946,-0.0022516653,-0.018527823,-0.06176826,-0.06523306,-0.035720218,0.024034139,0.008875277,0.00073294074,-0.001625283,-0.08003013,-0.051290322,-0.01814233,0.085605346,0.013331283,-0.03010551,-0.048565738,-0.027283208,-0.04435244,0.037157748,0.041318797,-0.014179371,0.0036592274,-0.116387874,0.018144922,-0.014157717,0.00045252178,0.037555095,-0.06489841,0.02453944,-0.02674559,-0.07725351,-0.010313604,0.026350722,0.019179873,0.11441197,0.012479582,0.0068055023,0.038734004,0.06120771,-0.00608611,0.13921183,-0.008027778,0.055712935,0.035060022,-0.0139476145,-0.03158394,-0.0028753267,-0.03118206,-0.05333158,-0.03450611,-0.08644049,-0.055484448,0.02710353,-0.008330059,-0.06088862,-0.111614466,0.07009279,-0.0039825104,0.042115834,0.0699815,-0.06285605,-0.03825272,0.10598123,0.07123183,0.11527086,-3.0846873e-08,0.015131724,0.0074685584,-0.03172454,-0.002141199,0.052517425,0.019654661,-0.11839801,-0.035675436,0.04827018,0.0015749065,-0.0059150825,0.13615572,0.059273575,0.02985026,0.009082157,-0.04404538,-0.023216661,-0.03372104,-0.020862428,-0.10323338,-0.12740359,-0.025955651,0.02731271,0.011445421,0.0030820356,-0.021582132,0.06677242,-0.0077803857,0.01078565,0.0023792186,-0.04577626,0.016401188,-0.04231328,-0.006663333,0.013281446,0.037070133,0.0477522,0.021302192,-0.088007756,0.09716953,0.014462921,-0.068852454,-0.07680959,0.037445504,0.009442845,-0.009446399,-0.035272226,0.025733266,0.004946703,-0.042024605,0.013614992,-0.0017303408,-0.033856694,-0.007280037,-0.03594342,0.06910304,0.0054498096,0.0026480278,0.09175095,-0.06405206,-0.04369868,-0.025167728,0.13095546,-0.02647032 +2.3.1.132,"4-Coumaroyl-CoA, feruloyl-CoA and caffeoyl-CoA can also act as donors, but more slowly.",384,1.0,-0.045012873,-0.040841028,-0.06767393,0.015982509,0.09316648,0.0050507183,-0.042926863,0.061651666,0.02744876,-0.0465961,0.021733938,-0.09461914,-0.064356595,0.08249034,-0.013975741,-0.048593525,0.008014745,0.00868301,-0.025347259,0.025683295,-0.021859042,-0.05076304,0.021779241,0.0062517785,0.022059362,0.04126525,-0.054303892,-0.07389967,0.065914266,-0.088382706,-0.046267614,0.042215984,-0.025661878,-0.007899224,-0.0028872932,0.07575908,0.004451877,-0.023462964,-0.014531079,0.09059459,0.011193351,-0.080053434,0.03403453,0.036605425,-0.07736093,-0.08960091,0.033809956,0.003637068,0.059794266,0.024831515,-0.015668524,-0.00019011908,-0.10377331,0.07509414,0.006090341,0.009439597,-0.045396432,-0.045296606,0.018258613,0.056069117,0.026681913,-0.012541853,0.00086638215,0.03784369,0.04585023,0.058181576,0.05891916,-0.019706782,0.046718538,-0.015014859,0.056384917,-0.00075194327,0.04799303,0.008782281,0.025757506,0.08147286,0.019634737,-0.004992895,0.03720968,0.004887315,-0.06345015,0.060596045,0.045047674,0.017071452,0.009299173,0.060999442,-0.047792602,-0.05798125,-0.07122127,0.035897054,0.0017060443,0.08091073,0.061365902,-0.008877378,-0.13233133,0.036591757,0.06335267,-0.012667426,-0.020814724,-0.0011487667,-0.061010357,0.07953884,-0.0047661094,-0.021648996,-0.03614677,-0.09369368,-0.043225013,0.015922893,0.016255401,0.03817862,-0.00948467,0.026326858,0.039122757,0.038590252,-0.002551176,0.07430396,-0.069470845,-0.048753597,-0.04224315,0.061004188,0.034271926,-0.010202248,0.012122328,-0.052301373,0.004175423,-0.01309767,-0.028910024,2.0134815e-33,0.065653704,0.027385533,0.080974914,0.099755876,-0.049675092,-0.020505002,-0.06051923,-0.0139092505,-0.051142722,-0.032296512,-0.03052918,-0.009369504,0.05978927,0.072332956,-0.059512865,-0.10561515,-0.053838875,-0.03844119,0.05477845,0.02037929,0.07945471,0.084888905,0.035792083,0.056659482,0.046571985,0.0032422715,-0.07392989,0.10109367,0.07007499,0.041856043,-0.045430996,-0.0031331351,0.009413098,-0.058181576,-0.040900543,-0.05527242,-0.022473698,-0.054823954,-0.060300715,0.07743495,0.0226816,0.0064624646,-0.061733454,-0.011354276,0.09782698,-0.09296238,-0.024494367,-0.017426109,-0.1364133,0.05768909,0.0061670667,-0.015366224,-0.0015000035,-0.001377696,-0.0511148,-0.017827002,-0.030426633,-0.026299406,-0.021970898,-0.0006022358,0.08096001,0.04889965,0.011287539,0.03451319,0.0056134975,0.024721853,-0.005735469,-0.05115031,-0.04100004,0.0061443667,-0.0013070618,-0.010772077,-0.019887846,0.028851606,0.08968935,-0.048248585,0.008241591,0.03784558,0.068583645,-0.010487245,-0.0043515493,-0.023994321,0.07086261,0.039958414,-0.008378503,-0.015551352,0.016583517,-0.08444416,-0.012391839,-0.06968473,-0.0019295125,-0.046784274,0.044282597,-0.11874409,-0.02053183,-1.960253e-33,0.12040998,-0.12354903,0.041401513,-0.050418608,-0.033610005,0.050843086,0.0307247,-0.091679715,0.092751294,0.046092592,0.12340094,0.026188193,0.057060905,-0.05148039,0.027798435,0.02697317,0.018896902,-0.06199516,-0.016139258,-0.016440969,-0.023217047,0.054825198,0.040779795,-0.04866062,0.058746602,0.050492942,-0.043044597,-0.05858071,-0.0104733175,0.03326946,-0.0022516653,-0.018527823,-0.06176826,-0.06523306,-0.035720218,0.024034139,0.008875277,0.00073294074,-0.001625283,-0.08003013,-0.051290322,-0.01814233,0.085605346,0.013331283,-0.03010551,-0.048565738,-0.027283208,-0.04435244,0.037157748,0.041318797,-0.014179371,0.0036592274,-0.116387874,0.018144922,-0.014157717,0.00045252178,0.037555095,-0.06489841,0.02453944,-0.02674559,-0.07725351,-0.010313604,0.026350722,0.019179873,0.11441197,0.012479582,0.0068055023,0.038734004,0.06120771,-0.00608611,0.13921183,-0.008027778,0.055712935,0.035060022,-0.0139476145,-0.03158394,-0.0028753267,-0.03118206,-0.05333158,-0.03450611,-0.08644049,-0.055484448,0.02710353,-0.008330059,-0.06088862,-0.111614466,0.07009279,-0.0039825104,0.042115834,0.0699815,-0.06285605,-0.03825272,0.10598123,0.07123183,0.11527086,-3.0846873e-08,0.015131724,0.0074685584,-0.03172454,-0.002141199,0.052517425,0.019654661,-0.11839801,-0.035675436,0.04827018,0.0015749065,-0.0059150825,0.13615572,0.059273575,0.02985026,0.009082157,-0.04404538,-0.023216661,-0.03372104,-0.020862428,-0.10323338,-0.12740359,-0.025955651,0.02731271,0.011445421,0.0030820356,-0.021582132,0.06677242,-0.0077803857,0.01078565,0.0023792186,-0.04577626,0.016401188,-0.04231328,-0.006663333,0.013281446,0.037070133,0.0477522,0.021302192,-0.088007756,0.09716953,0.014462921,-0.068852454,-0.07680959,0.037445504,0.009442845,-0.009446399,-0.035272226,0.025733266,0.004946703,-0.042024605,0.013614992,-0.0017303408,-0.033856694,-0.007280037,-0.03594342,0.06910304,0.0054498096,0.0026480278,0.09175095,-0.06405206,-0.04369868,-0.025167728,0.13095546,-0.02647032 +2.3.1.133,"Caffeoyl-CoA, feruloyl-CoA and sinapoyl-CoA can also act as donors, but more slowly.",384,1.0,-0.098193385,-0.041182343,-0.057238437,0.0507236,0.098964214,-0.01068462,-0.021227749,0.06075513,0.026342759,-0.0721156,0.020017777,-0.08240949,-0.03651048,0.09222205,0.014276262,-0.057371847,0.020098073,0.017418357,-0.002294439,0.04183751,-0.025800038,-0.027800638,0.024704007,-0.009252435,0.02751108,0.057876848,-0.04526211,-0.079350576,0.05529629,-0.08996783,-0.062902726,0.047614552,0.009300351,-0.018803207,-0.013883451,0.1006369,-0.016827516,0.003016917,-0.03276848,0.06995798,0.0075620282,-0.094401054,0.03334669,0.004148651,-0.07177151,-0.09576182,0.054029893,0.0030255408,0.040379424,0.048930243,-0.024411727,-0.01774838,-0.06639648,0.056419883,-0.011440136,0.005434302,-0.0042828596,-0.05375022,0.0002702291,0.03947037,0.010505855,-0.012554499,-0.0111674825,0.040312074,0.037790585,0.047293942,0.057029143,-0.0045669377,0.048957404,-0.04379655,0.05118743,-0.018942049,0.062167346,0.05429429,0.03608777,0.06978169,0.041878674,0.01822235,0.032326486,0.016591897,-0.104824506,0.038740635,0.024826465,0.041912496,0.022629445,0.09516149,-0.043754425,-0.028932326,-0.09476163,0.051778443,0.014612538,0.10343987,0.055427518,-0.004434715,-0.10656439,0.0015608968,0.026451278,0.00494169,-0.0674413,0.0044297907,-0.05574419,0.07531386,-0.0072201523,-0.030094977,-0.021843808,-0.09818587,-0.08053249,-0.034524154,0.025906911,0.013600947,-0.0031123124,0.042162634,0.0317501,0.078386195,0.0063414327,0.05771241,-0.07613273,-0.02004262,-0.031183762,0.071162105,0.029104713,-0.017617805,-0.02266432,-0.038810983,-0.030792933,-0.042794373,-0.036676385,2.4325678e-33,0.031840824,0.021243842,0.049889073,0.068377055,-0.036375497,-0.015680369,-0.049484264,-0.0053602294,-0.04621801,-0.017044405,-0.051731367,0.008805306,0.047807153,0.073365115,-0.050791774,-0.106810056,-0.0632183,-0.024159938,0.039557185,-0.006700617,0.099902146,0.0574256,0.061475012,0.035232905,0.01698531,-0.0025349697,-0.0757533,0.085670695,0.057361003,0.035276745,-0.037064318,-0.040465828,0.029047148,-0.048140004,-0.06289788,-0.05746995,0.013968183,-0.06280026,-0.068155624,0.0847698,0.0237236,0.01814823,-0.05374295,0.006387063,0.06229838,-0.08422141,-0.0019602156,0.0010088334,-0.10529453,0.05740818,0.015207044,-0.04832362,0.0117566325,-0.02986063,-0.040846735,-0.017413773,-0.028708799,-0.03289121,-0.05610749,0.0027468507,0.07872421,0.033486914,0.033625834,0.008937322,-0.01851755,0.032225378,-0.0070357914,-0.050251618,-0.039627273,-0.020439537,0.011179711,0.025514448,-0.029662846,0.04342905,0.05943143,-0.056247227,-0.010610142,0.05461807,0.07336852,-0.008377293,0.025089005,-0.01867136,0.061366066,0.0018537405,0.008235206,0.004615781,0.045968663,-0.10545918,-0.018202255,-0.04519218,-0.021439178,-0.025329715,0.022451587,-0.10472785,-0.008575421,-2.307397e-33,0.101072714,-0.15582001,0.05484843,-0.060129046,-0.02968122,0.019278549,0.03441208,-0.07703637,0.097666666,0.04245671,0.07692338,0.011133071,0.0849704,-0.048729647,0.023572387,0.017081805,0.023561671,-0.060741622,-0.03587174,-0.03532816,-0.068080746,0.06202681,0.040179558,-0.04646475,0.025754934,0.04990223,-0.070570864,-0.03266974,-0.00080274144,0.033088926,-0.021485526,0.0042119236,-0.08957315,-0.06728999,-0.008140737,0.07588039,-1.4592207e-05,0.0074592507,0.010282465,-0.07617694,-0.04905748,-0.003234294,0.068158105,0.014109155,-0.03850264,-0.059641324,-0.031368352,-0.07596454,0.0007824064,0.038506437,0.01575674,-0.0047750804,-0.0655985,0.044813477,-0.023764657,0.012056227,0.032855336,-0.046237543,0.0001771234,-0.058991693,-0.0497574,-0.013526272,-0.009313968,0.017678192,0.118811354,0.016504984,0.016937923,0.036656532,0.05879989,0.017869776,0.17467852,-0.018570244,0.046914108,0.00913331,-0.038452283,-0.014286133,0.014961928,-0.01320293,-0.050626088,-0.07206517,-0.03900436,-0.023951054,0.0027927652,0.0020784182,-0.058192983,-0.08534353,0.07596869,-0.014551177,0.046275012,0.07239172,-0.074947104,-0.044651944,0.09016367,0.08793514,0.1521431,-2.998831e-08,0.0033949604,-0.0020427518,-0.04556977,0.020766094,0.067275055,0.007076956,-0.10436395,-0.049794443,0.034885623,0.0077376324,-0.032278072,0.13783565,0.0835504,0.019389266,0.0143845435,-0.0200991,-0.00040393244,0.019880837,0.00023149964,-0.08078559,-0.09099301,-0.009268991,0.040377006,0.0039921096,0.0065893605,-0.03424915,0.049754776,-0.012625843,0.015451584,0.002809739,-0.06780171,-0.022334,-0.054322314,0.00053038646,0.04030162,0.061699305,0.039911184,0.0055299895,-0.06191355,0.08529463,0.017974332,-0.07022615,-0.08592561,0.046427388,-0.008870054,-0.04880506,-0.042412754,0.025162555,0.011296116,-0.035109892,0.03692048,0.007596921,-0.0076474897,-0.03348905,-0.058210254,0.073764324,0.01640941,0.018133443,0.08826197,-0.013422618,-0.043599453,-0.0036820592,0.13948706,-0.050428342 +2.3.1.134,Di-D-galactosyldiacylglycerol can also act as acceptor.,384,1.0,-0.034409825,-0.087746285,-0.013559895,0.037820954,-0.02789273,-0.0660419,0.083652,0.024190012,0.06224147,-0.00903324,0.07011346,0.046548806,-0.041280687,0.093886025,0.02380564,0.014177848,0.011510382,0.03297227,-0.018788056,0.06697989,0.045608513,0.03520031,-0.00021820203,0.051938932,-0.03364501,-0.039908167,0.043618333,-0.008837963,-0.028150668,-0.059974447,0.039358925,-0.030866029,0.02234217,0.0004426027,-0.020272348,-0.024967933,-0.025861595,0.035599854,-0.040751666,0.004958901,0.02527838,-0.064398,0.016765775,0.035862416,-0.043939788,-0.009478594,-0.08622017,0.05626991,0.03445255,-0.007614342,-0.0136613995,-0.0422045,-0.052014086,0.04369458,0.002757303,0.08979737,-0.07554314,-0.018226454,0.015008982,-0.065156974,0.026899181,0.02299717,-0.01880681,0.05991946,-0.082080565,-0.07388923,0.015471006,-0.054967504,0.056537338,0.020337805,0.0070562577,-0.070255496,0.010865378,-0.02689162,0.05839432,0.011162575,0.015420709,-0.03289997,0.093547575,0.0067460425,0.036198474,-0.015608832,0.005514781,0.061042108,0.014729555,0.015548782,0.0026158052,-0.009466987,-0.04847805,-0.027612487,-0.012196398,-0.097736426,0.002231268,-0.05980057,-0.03846319,-0.06429227,0.052658748,-0.07073881,0.013961755,0.019198157,-0.04691651,-0.016449722,-0.039953236,-0.01870999,-0.055986375,0.011425533,-0.034142494,-0.0537174,-0.004955456,-0.025812935,-0.018856978,-0.09138991,0.11094122,0.033756327,-0.08764745,0.045861296,-0.0023056918,-0.033624373,0.014610995,-0.09182127,-0.036110885,-0.039380237,0.04783349,-0.048607647,-0.03460864,0.10271738,0.029128721,1.409533e-33,-0.014642992,0.02152311,-0.0022210919,-0.036335636,-0.018642705,-0.00019003701,-0.078121915,-0.014596324,-0.03371801,-0.068019,-0.055477623,-0.022355318,0.0106376875,0.12979168,-0.04180937,0.045009803,0.024917664,0.082123555,0.051095847,-0.0662781,-0.0031472265,0.08219633,-0.051845904,-0.008960288,-0.02460137,0.06613052,-0.021927416,0.063199244,0.1202688,0.004226001,0.038392752,-0.04717563,0.010128705,0.062332362,-0.0015000361,0.12151839,-0.021084871,-0.04167975,0.034405716,-0.09957725,-0.019737478,-0.026771579,-0.08463418,0.037186835,0.012425176,0.027589224,-0.08472916,-0.027734386,0.016927935,-0.017780118,0.015819496,0.0017492846,-0.0028014814,-0.006007201,-0.0030262594,0.008557118,-0.017194955,0.05275529,0.032411776,0.019215807,-0.03697062,0.106151894,-0.047125373,0.0064012846,0.012111156,-0.0025450047,-0.050326508,-0.07049646,-0.074650705,-0.04477293,-0.020551315,0.022515522,0.03515703,0.04420065,0.0071219816,-0.04424031,0.041424174,-0.0056935106,0.020287842,-0.0055310787,-0.055619296,-0.014921779,0.0051281876,0.050729524,-0.02083203,0.008716214,-0.03840372,-0.08869104,0.033299323,0.0015840871,-0.11723441,-0.0043795905,-0.056702368,0.11026263,0.070440456,-3.387162e-33,0.018380255,-0.026625657,0.097538024,0.08053539,0.057814684,0.10688113,0.042869784,-0.037173547,0.17012247,-0.055162206,0.054259446,-0.02449146,-0.03169858,-0.0349681,0.0065814583,0.024379319,-0.026634142,0.026922094,-0.12093373,0.044640332,-0.015280085,0.067731194,-0.035660118,0.07927086,0.011447078,0.004506053,-0.013832472,-0.016543975,-0.036011513,0.08121959,0.052926507,0.020544913,-0.032218605,-0.10305065,-0.030779783,0.0044354787,-0.11706158,0.0408176,-0.10512468,0.024585858,-0.05902654,0.0042614616,0.05912382,0.05809058,0.09299192,0.0226358,0.043375187,-0.020637548,0.053512223,-0.034079235,-0.0129542425,-0.003805162,-0.0041852915,0.10147342,0.089877255,0.13512917,0.06908924,0.011894572,-0.023148933,-0.054721378,-0.039725095,-0.06979498,0.078185394,-0.07564222,0.03753167,0.00987031,-0.00964949,0.025521666,0.069229424,-0.06744295,0.08826745,0.009388622,-0.009620807,0.08392549,0.034506727,-0.01647395,-0.08359535,-0.08973088,-0.017666982,0.026925197,-0.021744778,0.074262075,0.02502525,-0.027588492,0.008146978,-0.04953631,-0.024804018,-0.022142034,-0.05319514,0.060072687,-0.021339208,0.026547458,-0.016874455,-0.031807378,0.07191912,-2.726643e-08,0.05252883,-0.04394414,0.016236022,-0.09163008,-0.080590084,-0.040448595,0.06614255,-0.014056207,-0.0023148134,-0.083511025,-0.020158077,0.13436027,0.015285998,-0.006830534,0.037225295,0.019940363,0.002261272,0.029698048,-0.049633645,-0.04204435,-0.02364616,-0.036933888,0.026045496,-0.048536398,-0.03966178,-0.057121076,0.05341859,0.024613373,-0.05293543,0.020881357,0.04103983,-0.006517943,-0.06308614,0.027291752,0.024673194,0.048700657,-0.0105948765,-0.0076260483,-0.013293836,0.1311608,0.04626434,-0.020042488,0.0011193183,0.03714363,-0.08114601,-0.021331904,-0.011740787,0.0138650965,-0.073481046,0.093140885,-0.02672171,-0.0072057615,-0.031523336,-0.08051234,-0.091069266,0.0014523206,-0.014599615,-0.01091554,-0.05099483,-0.045272764,0.028841328,-0.050935216,0.15070422,0.035363447 +2.3.1.135,"A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol.",384,1.0,-0.11157068,-0.03285962,-0.061134417,0.0068574115,0.028577477,0.10296492,0.040675588,0.053853378,-0.010364944,0.0013024556,0.033545986,-0.0012579162,-0.061162673,0.05117266,-0.07571868,-0.005058333,-0.07382953,0.08384146,-0.026548479,-0.08656125,0.05467256,-0.050322082,0.0016620923,0.04751068,0.012560867,-0.06447626,0.010498414,-0.042767473,-0.00919297,-0.04916355,-0.01891228,-0.02570437,0.005531874,-0.003134368,-0.01438374,0.10659335,0.04459906,-0.07031757,-0.037274107,0.046369996,0.014236744,-0.009901029,-0.037103336,0.019612955,0.094295576,-0.08012714,0.01786127,0.07263653,-0.066428944,-0.016821336,-0.058826294,-0.045792688,-0.15206738,0.034204245,0.043100737,0.12493829,-0.039823532,-0.01861668,0.036114026,0.066092536,0.072424665,-0.08560928,0.03765218,0.007695447,0.028547244,-0.08527548,-0.003942315,-0.04426329,0.011030352,0.005886562,-0.05109105,-0.07167288,-0.11590705,-0.012338098,0.013644052,-0.0025903455,-0.032903314,-0.036310174,0.025107186,-0.0483582,0.074345395,0.0080022,-0.035624586,0.08648375,0.13152735,-0.0683727,-0.016794002,-0.017965749,0.058243692,0.04074832,-0.018636234,-0.028393466,-0.033907402,-0.037032694,-0.0804748,-0.014295401,0.026765713,-0.033870917,-0.007112769,-0.00871539,0.0035571563,0.007999291,0.028581176,-0.060216565,-0.12135605,0.0031613372,0.005494502,0.027992915,-0.027398413,0.0027298438,-0.041007552,0.035738938,0.015676739,-0.000876859,0.03385328,0.094384804,-0.021348348,-0.06528896,0.08531539,0.008312609,-0.07779169,-0.005342467,0.019857606,0.05018539,0.026564853,0.032234453,-0.0980544,2.4230913e-33,0.019992927,0.068102345,-0.055750158,0.07533179,-0.0139529,-0.022246916,-0.08974705,0.043425515,-0.055924326,-0.057386775,-0.0035806866,-0.0028247312,-0.003949991,0.07041681,0.024436643,-0.061188146,-0.0043355823,0.05347396,0.058147624,-0.06371504,-0.07655544,0.06104317,-0.041889798,-0.05353446,0.020060997,-0.0022089516,-0.05509574,0.030880872,0.001971502,0.009443815,0.022699539,-0.013164571,-0.06019726,0.02022754,0.04286297,0.03974371,0.044224724,-0.06519148,0.013696756,0.074995056,-0.0014892785,0.012419632,-0.052609973,-0.067561716,0.057265308,-0.030210694,-0.07148079,0.09310181,0.010744105,0.0004649545,0.008706996,0.0052266284,0.022200713,-0.06650497,-0.08637547,0.018482378,-0.08930874,-0.011415435,-0.00644931,0.019753873,0.0021717055,0.035796195,-0.05882398,0.04828021,0.040613145,0.03017592,-0.027584035,-0.056657974,0.001303904,0.066070475,-0.044660598,0.04997876,0.061863963,-0.024136648,0.03674795,-0.009570779,-0.075624354,0.06263472,-0.004829463,0.052685972,0.0054323543,-0.016575433,0.019600913,-0.024116732,-0.017910087,-0.066808715,0.029373216,-0.056684557,0.02299537,-0.031120744,0.050953507,-0.0800108,0.021468168,0.06751773,0.042114165,-3.188237e-33,0.025809158,-0.1292513,0.025082724,-0.066647194,-0.047932245,0.05844777,-0.009399905,-0.016765995,-0.0062104273,-0.07923695,0.027861468,-0.04587684,0.03395528,-0.059110656,-0.014845666,-0.07874846,-0.0033837948,0.0023193269,0.023588173,-0.03573574,-0.013639671,7.1019655e-05,-0.022484941,0.10047821,-0.030703567,0.077686846,-0.0507646,0.11427015,-0.045965433,0.06320722,-0.047466177,-0.07973643,-0.023921484,-0.00923888,-0.03186387,0.05842588,-0.040777072,0.06071418,-0.020050064,0.08199716,0.08898927,-0.009024302,0.06899841,-0.01118303,0.038817495,0.04763844,0.003116517,0.037912033,0.0010799849,-0.0516235,0.07474647,0.012155948,-0.044242606,-0.046189286,0.02378085,0.090263516,-0.0009983449,-0.035203476,0.062002495,-0.0023861423,-0.04463784,-0.09913929,-0.0136980675,0.0685136,0.068016015,0.038344976,0.012047282,-0.04555841,0.049519427,-0.018670904,0.15511857,-0.00049441686,0.01322439,0.065383166,-0.020104831,-0.033752277,-0.016705884,-0.03805478,-0.06144044,-0.027686125,0.01655324,-0.10052757,-0.026346784,-0.061711367,0.056233555,0.022433998,-0.017595999,0.016796557,0.04558703,-0.01245284,-0.038066946,-0.020764118,-0.11027178,0.012848865,0.084077105,-3.700652e-08,0.04342843,-0.036421478,0.08999137,-0.03403447,0.03363552,0.018628161,0.057920836,0.024762593,0.054898206,-0.020998532,-0.053057395,0.08628582,0.012896554,0.05394537,0.069660366,0.06591616,0.008589394,0.06074015,-0.018315846,-0.035472326,-0.044227853,0.012599734,-0.009674725,-0.03104587,-0.036567613,-0.09301203,0.013992254,0.13429041,0.05729921,-0.005620684,0.07030917,0.00695345,0.06447311,0.025562035,-0.02236651,-0.0011491873,0.033634286,-0.029118717,-0.052484125,0.04568418,0.0025197892,0.017434347,-0.0037043127,0.035233274,0.0022926922,-0.004527817,0.07446445,-0.009582154,-0.031152679,0.088096984,0.010554813,-0.016488014,-0.028986,-0.0955165,-0.118905686,-0.03517237,0.023871304,0.013841531,-0.006025856,-0.02375151,0.031690728,0.068975784,0.1284748,-0.0070780353 +2.3.1.136,Acts only on substrates containing more than 14 sialosyl residues. Catalyses the modification of capsular polysaccharides in some strains of Escherichia coli. ,384,1.0,0.034582626,-0.116205186,-0.038866717,-0.02353066,0.045350604,0.0152854975,0.019070257,0.049217597,0.09436887,0.0011039135,0.025116412,-0.013393206,-0.043020684,0.078621745,-0.043025948,-0.09597573,-0.048431337,0.05882248,0.02536565,-0.02967066,0.120717116,-0.05735739,-0.055152923,0.0006396436,-0.008798851,0.0036128543,0.028065933,-0.055856783,-0.024981637,-0.1246149,-0.052169837,-0.025915012,0.07432305,-0.070299655,0.085925065,0.07237502,-0.019567555,-0.047402076,0.119280085,-0.07921685,0.0011543587,0.013179792,0.04920754,-0.017383223,-0.038159627,-0.055438664,-0.016812216,0.00032129858,-0.018404812,-0.063144185,-0.025295326,-0.041780468,0.0010996608,-0.009060867,0.019467575,0.0041457466,0.018932242,-0.058228638,0.05202559,0.09777488,0.03552826,-0.03340873,0.052558165,-0.034199685,-0.09643561,-0.054508183,0.10239662,-0.05875516,-0.03794247,0.058464855,-0.11262358,0.05486022,-0.039591927,0.021526748,0.057822518,-0.022212103,-0.011314356,-0.04269589,0.044800278,0.069944076,-0.054534905,-0.008138653,-0.0057772696,0.048263118,-0.006017916,-0.0013308091,-0.050386786,-0.003281481,0.026937973,0.0475853,-0.0044980855,0.03836657,0.03362403,-0.0346863,-0.07427197,-0.026106995,0.009595279,-0.022171346,0.059459694,-0.0032374954,-0.019675452,0.01193715,-0.003495543,-0.038975507,0.0032775751,0.01246052,0.022830704,0.02294757,-0.0034154486,0.012547492,-0.0017025104,0.062286813,0.0075835367,-0.0099330675,-0.08115379,0.05307957,0.09157308,-0.0650908,-0.051742643,-0.056937892,0.006519546,-0.12424146,0.063471414,0.0012371956,-0.12534742,-0.0052384315,-0.04152747,1.4036636e-33,0.0056075896,0.05397164,-0.013456733,-0.034314536,0.02488996,-0.068080924,0.033721596,-0.04266955,-0.0662201,-0.011478348,-0.03839663,-0.07982949,0.005076854,0.069885775,0.070000045,-0.016174251,0.02506104,-0.009054007,0.008390946,-0.04408932,-0.024743995,0.026170129,0.021324566,-0.042272683,0.07482352,0.05059869,-0.090890594,0.030456206,0.032272667,0.012534211,0.03622417,0.055981297,-0.088008836,0.102384895,0.09745938,-0.014648943,-0.00632454,-0.019602634,0.059383534,0.0206551,0.04757539,0.10394677,0.0017382104,-0.037793178,0.021457497,0.07299748,-0.01609925,0.121868216,-0.020286309,0.0534751,0.03909252,0.047975473,-0.021935064,-0.034365,0.01826543,0.057225786,-0.013712068,-0.04985735,0.029881807,0.057548527,0.029812424,-0.007990547,0.0007968427,-0.009185839,0.035093863,0.0541703,-0.0018979446,0.038292028,-0.001009173,0.029091477,-0.05395094,0.008980358,-0.07844968,0.06201488,-0.04994658,-0.050541114,-0.06733827,0.048505235,0.10461847,0.037746064,0.070215866,0.05132042,0.008060056,-0.05958569,-0.04069608,-0.011043085,-0.004632158,0.03701543,-0.027494503,0.047530778,0.03610818,-0.1181019,-0.01948706,0.07694933,-0.069546305,-4.5612028e-33,0.08893624,-0.10433956,0.025163854,-0.070477836,-0.12762184,-0.015530326,-0.0013953897,-0.08261405,-0.012262117,-0.0411981,0.029373435,0.019698016,-0.009928314,0.033525284,-0.065331906,0.007857163,-0.010714881,0.062472846,-0.082005434,-0.056733105,-0.012432278,0.011458745,0.04573025,-0.0024263742,0.005919113,-0.027323054,-0.05895735,0.040159218,-0.03216507,0.046913072,-0.007818529,-0.073062696,-0.025748754,-0.051733226,-0.050638966,-0.035691623,-0.049724247,-0.008948287,0.11248363,-0.051809482,0.045865767,0.014871934,0.030670092,0.027055854,-0.03822481,0.030879907,-0.033880785,-0.02158531,0.001694154,-0.04965003,0.0024646528,-0.005672269,0.01722652,-0.026526116,-0.030102534,0.053641688,0.08375341,-0.028903272,-0.020001322,-0.096222736,-0.046685852,-0.016881138,-0.011849487,-0.04318801,0.061007258,0.04073191,-0.030550031,-0.07652885,0.054417264,-0.08930125,0.066188686,-0.00026665005,-0.04126827,0.021234028,-0.04665271,-0.051178988,-0.12921746,-0.019666309,-0.01929824,0.011130919,0.014497131,-0.012338412,-0.038676146,-0.07223859,0.059337005,-0.039238244,0.084183015,0.06865129,0.008445669,0.008930086,0.004513801,0.035510115,0.03802671,0.08745549,0.10230356,-2.936218e-08,0.0050234385,-0.01836191,-0.04080172,-0.07779305,-0.06692122,0.09253799,-0.069015354,-0.05438663,0.023788406,-0.03411984,-0.022325939,0.1323228,0.0012798583,0.062204275,-0.0020382553,0.019605296,-0.031272385,-0.03145813,0.014257725,-0.014583941,-0.06762599,0.036648873,-0.028601224,-0.025642874,-0.0019477519,-0.061699662,0.033694353,0.049078654,-0.03431603,-0.003746059,-0.0007053714,0.029901024,-0.07890789,-0.0149795525,0.024753999,0.023420205,-0.00417142,-0.10356254,0.028846633,0.025499634,0.02967958,0.010582427,-0.09404801,0.008034656,-0.021233207,0.083680235,-0.10243537,0.045847304,-0.04492917,0.09002255,0.058430076,-0.0433635,-0.01991867,0.057389703,-0.056835555,0.024058184,0.034915987,0.0020785586,0.018066403,0.023591755,0.08136559,-0.0022685502,0.12158234,-0.02295395 +2.3.1.137,"Acts on a range of acyl-CoAs, with optimal activity with C6 or C8 acyl groups. cf. EC 2.3.1.7 (carnitine O-acetyltransferase) and EC 2.3.1.21 (carnitine O-palmitoyltransferase).",384,1.0,-0.121548645,-0.03943835,-0.09868039,0.031845406,-0.020864299,0.061953194,-0.11049608,0.04762368,0.032576546,-0.06316393,0.073846884,-0.09289825,-0.106509976,0.024868645,-0.016702572,0.025088528,-0.05186959,0.036830932,-0.030491216,-0.025950337,0.010133207,0.03874757,0.052019287,0.014997809,0.038082033,-0.07707481,-0.046079777,0.0006629729,0.02346419,-0.10683415,-0.007553181,-0.031041458,0.060453176,-0.01424139,0.05655219,-0.00296454,0.0018216823,-0.055471018,0.036334384,0.03904942,0.042218555,-0.06536035,-0.010969679,-0.007356304,0.021853454,-0.0766654,-0.005899578,0.04264303,0.021311324,0.008638168,-0.024358662,-0.021299036,-0.10769264,0.07438794,-0.02439434,0.028071787,-0.05429934,-0.05902303,0.04243695,0.066726446,0.033432826,-0.019379755,0.00031706737,0.019095635,-0.020128017,-0.05687013,0.10011047,-0.036402572,0.03625837,-0.0071049165,-0.08032051,-0.07935016,-0.040875256,0.0549271,0.019151151,0.00018336375,-0.03622441,-0.011174348,0.037523,-0.036713276,0.022571294,-0.0109832045,-0.011555375,0.0630075,0.043371864,-0.063145764,-0.06748096,0.015080969,0.0017443745,0.062428046,0.03401843,-0.0010543725,-0.013320296,-0.037274066,-0.066790186,0.030260958,0.13498926,-0.021285376,0.03742795,-0.010319018,0.021371415,0.066549115,-0.048657183,-0.017046593,-0.033562753,-0.03193387,-0.010839009,0.045810197,-0.008996526,0.01054978,0.0014377811,-0.04879339,-0.023978414,-0.08904947,-0.042855185,0.07244972,-0.090135664,-0.01961112,0.048394095,0.04577453,-0.05453923,-0.017393762,0.01973406,0.091157705,0.03888702,0.047811102,-0.05949014,1.8084437e-33,0.05014354,0.050934833,0.035994716,0.041223533,0.012337788,-0.076358676,-0.11707295,0.032587532,-0.03417956,-0.04094777,-0.030127076,-0.06323068,0.055892725,0.08059625,0.10963787,0.018559834,-0.009485407,-0.08756028,-0.0028888825,-0.03999132,0.03911158,0.02873208,0.018051904,0.039646056,0.043343075,0.03022296,-0.03794726,0.055694595,-0.0025788147,0.008761303,-0.032417655,-0.02223911,-0.007698326,0.004789036,0.047882494,0.0040473905,-0.042652555,-0.068822816,-0.014920098,0.07932555,0.07480381,0.08743556,-0.058570385,-0.061110258,0.084872134,-0.06027488,-0.023300076,0.07273226,0.004329849,0.080057435,0.033782087,-0.027769659,0.050411295,0.053966913,-0.042057477,0.06551763,-0.108028084,0.006090962,0.02097095,-0.030307708,0.07165631,0.035778504,0.033169925,-0.017415263,-0.03200162,0.08849369,-0.14029637,-0.05202725,-0.029354028,0.034480553,-0.033713683,-0.03728907,0.06832477,0.015639046,0.11235839,0.053122476,-0.04439053,0.08446801,0.015014992,-0.043513685,0.010092001,0.028258862,0.09905593,-0.009571495,-0.017180545,-0.022502605,-0.025278943,-0.047338154,0.030595848,0.029230686,-0.005519755,-0.024905754,0.016741788,-0.023584535,0.019165453,-2.5911486e-33,0.15977658,-0.041628763,0.029916622,-0.087326,-0.036085464,0.08491526,-0.051780496,-0.061876148,0.06256789,0.00164338,0.03368272,0.05426466,0.086147025,-0.09743316,0.0795223,-0.027055593,-0.00069172255,0.065602876,0.010787125,0.046735436,-0.024959274,-0.047948826,0.025235903,0.056430336,0.07907081,-0.007641512,-0.085360676,-0.0089606475,0.09107559,-0.026175682,-0.013480734,-0.009583346,-0.0080613475,-0.0058545433,-0.06479351,0.042919967,-0.048565473,0.092698395,-0.033772137,0.121069215,0.0034820875,-0.032416806,0.026160935,0.024466675,0.028178722,-0.0033846777,0.016452448,-0.020889254,-0.07342773,-0.061734878,0.06431202,-0.015319362,-0.05053344,-0.012083325,0.05714064,0.085793644,0.06991651,-0.08082327,0.030238071,-0.12074619,-0.0050436687,0.026878795,-0.017794035,-0.06834217,0.049005482,0.028161056,-0.05585188,0.060974926,0.008468222,-0.019178798,0.049020015,-0.0004767553,0.02769656,-0.027766015,-0.013805321,-0.012223734,-0.032853577,-0.106247775,-0.005801196,-0.06552918,-0.09734106,-0.038598716,0.017375913,-0.0021867303,-0.07993703,0.050185133,-0.011328737,0.007809079,0.07206239,0.07022669,-0.032252252,-0.033295143,0.013651579,0.04445872,2.5123847e-05,-3.6536782e-08,0.11238785,-0.03160639,0.017310295,0.01517873,0.0067147124,0.025595607,-0.075784974,0.0014284506,0.017252797,-0.012365676,0.0100827515,0.04822498,0.09400278,-0.028523732,-0.031770416,-0.012829834,0.04776164,0.033800352,-0.025577556,0.010649655,-0.102025114,0.00037163723,0.0134234065,0.053936902,-0.008865749,-0.09673832,0.022711875,0.026738148,0.009272549,-0.06872214,0.008772074,0.013240646,0.0120613305,0.014477163,-0.019747116,-0.02734629,0.030852858,-0.055949684,-0.068459205,0.06903274,0.06847542,-0.05341858,-0.07237047,0.04686353,0.047222625,0.0035599698,-0.0007748136,-0.014333968,-0.055389598,-0.008425153,0.020664165,0.0113216145,-0.08797772,-0.013425606,-0.01843491,-0.010523617,-0.03476595,-0.073517404,-0.013821952,-0.08817564,0.009372954,0.013610363,0.10065572,-0.01892277 +2.3.1.138,"Feruloyl-CoA, cinnamoyl-CoA and sinapoyl-CoA can also act as donors, but more slowly.",384,1.0,-0.09281254,-0.05431631,-0.08264924,0.015307178,0.06721266,-0.020348536,-0.03982419,0.040988587,0.020034669,-0.047355052,0.06356783,-0.07253464,-0.057937294,0.108631395,0.022316104,-0.03638357,-0.008855333,0.021156484,-0.032046117,0.06444845,-0.013092404,0.008988875,-0.0048957462,-0.0326532,0.013058495,0.023575738,-0.033651244,-0.060378198,0.06954018,-0.09363035,-0.06429538,0.036128867,-0.012546809,-0.038703952,0.0017041694,0.081301816,-0.081427865,-0.0025211493,-0.015702844,0.038787916,0.022258732,-0.10402375,0.022408808,-0.005311799,-0.11856322,-0.09026965,0.062106982,0.0273382,0.008243924,0.030110683,-0.02191077,-0.019382786,-0.07873135,0.0883428,-0.0117518855,-0.002791673,-0.046784196,-0.048684012,-0.02560693,0.0018156776,0.0049380437,0.055279166,-0.028600436,0.017981647,0.03487258,0.03697111,0.12121261,-0.010410385,0.03306612,-0.046568427,0.05903449,-0.013766825,0.0391593,0.054943096,0.04670275,0.058458015,0.027110312,-0.011194207,0.017453907,0.028185247,-0.0987907,0.045930434,0.027845725,0.015004894,0.012155049,0.09746374,-0.07590199,0.006686158,-0.09077127,0.023753097,0.011221224,0.09035277,0.025569163,-0.038102377,-0.09096333,0.04711054,0.02306302,0.018396972,-0.035891104,0.011616745,-0.04014942,0.1192568,-0.020270078,-0.06412515,-0.040386997,-0.0854367,-0.029519228,-0.0076824655,-0.032467596,0.016447352,-0.0043483283,0.006718165,0.07242111,0.0065400708,0.0013226586,0.061985824,-0.08974148,-0.0042821313,-0.024573067,0.07791007,0.036317606,0.007008519,-0.00057513587,0.0037425633,-0.012298643,0.01676914,-0.074219264,2.0892807e-33,0.025366163,0.0074989237,0.04954094,0.08829082,-0.06826879,-0.024914427,-0.06895631,-0.0024875812,-0.07805258,-0.027504638,-0.05343892,-0.0326296,0.058321897,0.04761259,-0.059514116,-0.09029567,-0.03883825,-0.05659211,0.053458788,0.011876624,0.08372201,0.08496207,0.06410708,0.026181549,0.05102206,-0.0050646854,-0.06641558,0.093368754,0.048503444,0.030166041,-0.014591841,-0.015618552,-0.00982119,-0.056253005,0.012232718,-0.03044124,-0.029048258,-0.049654815,-0.063109204,0.042465005,0.052977834,0.017165532,-0.06984629,-0.0047364077,0.067089066,-0.07434092,-0.01493787,0.0142668355,-0.11203606,0.018027538,0.057493046,-0.022414165,-0.006129664,-0.039377164,-0.065013714,-0.008248618,0.022887405,-0.04199331,-0.05961764,0.0121094575,0.030324483,0.031794418,0.012658937,0.034916807,-0.0023613938,0.016436853,-0.03651213,-0.02906048,-0.03936392,-0.000113920076,-0.015836315,-0.0034878352,-0.026567856,0.028620062,0.047550716,-0.06711447,-0.002737374,0.021658309,0.12124621,0.010319059,0.028723037,-0.03031005,0.041539066,-0.038066734,-0.0020763811,-0.0334866,0.016234366,-0.09629824,0.0073873377,-0.06234295,0.016624307,-0.04515811,0.009033011,-0.12872913,0.03290243,-3.4743433e-33,0.096521705,-0.1494755,0.037635054,-0.04207201,0.011331371,0.031186564,0.012405485,-0.07824688,0.105052136,0.04576058,0.06971457,0.013847415,0.06759665,-0.054202642,0.06726,0.029117448,0.045303103,-0.05094988,0.027459707,-0.042292062,-0.06624025,0.088723265,0.03708094,-0.048641235,0.0196016,0.02960136,-0.085430115,-0.0036810078,0.04768519,0.03286003,-0.011387,-0.016821517,-0.08036562,-0.11204668,-0.049170602,0.08695303,0.0068139127,0.020440929,0.01793466,-0.087911464,-0.027296178,-0.019558974,0.11106091,0.046468984,-0.04201046,-0.04316576,-0.0088909175,-0.065475106,-0.023281304,0.0088046575,0.012149029,0.021565525,-0.047025494,0.0020580806,0.027255408,0.043684464,0.037573375,-0.05646132,0.025943313,-0.055171665,-0.05743086,-0.02908306,0.0018665433,0.017593894,0.082691126,0.0012498783,0.025082435,0.03270312,0.03924161,0.007859479,0.13825098,-0.0057712067,0.0034611076,0.0042197905,-0.024711786,-0.06717753,-0.01953765,0.017648013,-0.036011655,-0.04456104,-0.047166478,-0.03989374,-0.012685607,-0.013080157,-0.012496563,-0.10111856,0.051888734,0.0046679284,0.027042136,0.042697918,-0.07033714,-0.016878285,0.119034894,0.07246159,0.10261771,-3.1911316e-08,0.009481683,-0.014511988,-0.03578536,-0.0058536334,0.06473851,0.006912284,-0.08089647,-0.011748466,0.022693044,0.036650106,-0.011495101,0.14449166,0.10180397,0.024291957,0.03957105,-0.012376928,-0.025227709,-0.029548064,-0.018952291,-0.10335655,-0.063610666,-0.003800828,0.028602982,0.023199296,-0.035565976,-0.019593995,0.05572033,-0.009143741,-0.020571731,0.0078130085,-0.059070177,-0.008903483,-0.062454607,-0.022033496,0.04148649,0.07187439,0.07182184,-0.03386533,-0.057885196,0.053669296,0.037774745,-0.031091468,-0.09394122,0.05309101,0.020609917,-0.029277403,-0.0377185,0.041279495,0.011356732,-0.046329696,0.03301502,0.005865179,-0.04755577,-0.01120189,-0.04372976,0.0595305,0.035208743,0.024974065,0.11358356,-0.017988734,-0.02020639,0.0034023896,0.13716827,-0.030150227 +2.3.1.140,"Involved, with EC 1.1.1.237 (hydroxyphenylpyruvate reductase) in the biosynthesis of rosmarinic acid. Characterized from the plant Melissa officinalis L. (lemon balm).",384,0.99999994,-0.018454421,-0.07271957,-0.13095456,0.050859746,0.09762648,0.062102787,-0.083527125,-0.006126443,0.015535558,-0.06605994,0.10576599,-0.011206973,-0.07010917,-0.11815589,-0.10264417,0.118515044,0.0027098143,0.042242385,-0.04508362,-0.0462947,0.01210284,0.004963689,0.014536172,0.02303468,0.0557819,0.0076753055,0.015017013,0.028002823,-0.053253032,-0.09877295,0.027723445,0.03015155,0.06238705,-0.06855501,-0.0026051886,0.054304373,-0.03211897,-0.06615008,0.07611202,0.04660471,0.054472987,-0.020895505,-0.03731636,-0.029745089,-0.045134816,-0.017104115,-0.033710137,0.027772939,-0.005170966,-0.025709175,-0.08762791,0.023033,-0.08514884,0.0081146555,-0.090977766,0.02743996,-0.0049439534,0.0093532475,-0.03695834,0.022565505,0.02990028,-0.0058123996,-0.0018816831,-0.052202716,-0.05211111,-0.017972948,-0.017473537,-0.11250488,0.13272603,-0.03152763,-0.044566836,-0.09938199,-0.005538592,0.025701648,0.0051828744,0.024913855,0.00039661402,0.013097364,0.040582433,-0.016902393,0.012268579,0.005825821,-0.047332086,0.0032046125,0.048534032,0.023868015,0.0036432988,0.013143956,0.07375807,0.07504705,1.7767808e-05,-0.009847967,0.039459627,-0.040501565,-0.03835831,-0.004546328,0.020810138,-0.07006861,0.01609063,-0.02416203,-0.014440676,0.11018002,0.016192714,-0.04927918,-0.076852985,-0.07479579,-0.029754171,0.051968906,-0.030108757,-0.028340364,0.083507225,-0.06315809,-0.0020969661,-0.016183482,0.010458364,0.07164542,0.03607175,-0.059315473,-0.10139083,-0.052312784,0.04917818,-0.03453362,-0.021256423,0.030387644,-0.058648452,0.005851003,-0.108668,1.8789282e-33,0.032519367,0.0040064068,0.0036870753,0.028721748,0.02134979,0.033715658,-0.07681617,0.0583291,0.028615806,-0.07283571,-0.07476812,-0.07261524,0.025808081,-0.053814236,-0.01633903,0.027874716,-0.015611391,-0.02659321,0.088264085,0.0017571728,-0.006197087,0.047003202,-0.07241226,-0.058261458,-0.023715794,-0.035061892,0.0007232438,-0.009535746,0.048420034,-0.024873953,0.07983892,-0.042212985,-0.015124771,-0.0028699066,-0.009243181,0.050686486,-0.04598166,-0.08632097,-0.009653817,0.07418356,-0.06788221,0.09615346,0.07891793,0.011869223,0.019905875,-0.017400859,-0.0114020165,0.055110265,0.1093333,0.009360608,-0.02873731,0.015697593,0.15634272,0.0838515,0.01423965,-0.0043142447,-0.06588359,0.06263737,-0.050433993,0.053945087,-0.016310021,0.076266296,-0.024052963,0.026609097,-0.06006481,-0.015383484,-0.06395535,-0.007825336,-0.027259532,0.013943239,-0.034389,-0.05900997,0.06665814,-0.010759188,-0.017719802,-0.013781222,0.015593307,0.018477833,-0.039334036,0.03171734,-0.056246065,0.0125051,0.055612657,0.03243216,-0.034348823,-0.019845303,-0.036337595,0.023049563,0.003654186,0.030145371,0.011074722,-0.07708549,-0.0037318117,0.08732711,0.012047821,-2.0743833e-33,0.042026777,-0.09636378,0.0026551767,-0.021134317,-0.015254207,0.024200764,-0.033998948,0.04536388,-0.06211181,-0.011321557,0.03870562,-0.019425767,0.0405444,-0.022053726,0.09661021,-0.03296559,0.035971276,0.13654974,-0.035771266,0.07736789,-0.08147965,0.10183439,0.06352868,0.001035763,0.06250912,0.05485491,0.09299426,0.004690525,-0.050306067,-0.0046577104,0.030403811,-0.0026762844,-0.0617152,-0.012412977,0.0074915173,0.072734475,-0.08418661,-0.0120599605,-0.00898425,0.09754422,0.0009202305,0.045152344,-0.01602268,0.07515555,0.08746582,0.009333263,-0.057270203,0.07780891,-0.05039961,-0.07065809,-0.0152714625,-0.0041120867,-0.03262749,0.03684127,0.046140518,0.032183923,0.039007396,0.08513883,-0.011326332,-0.044301204,-0.03337371,-0.029178845,-0.006434164,-0.06360212,0.02256798,0.029866697,0.058828004,0.06853313,0.04516863,0.020829592,0.03597392,0.026260639,0.024082934,0.12758279,-0.0489047,-0.033663876,-0.04575185,-0.011010444,-0.01739896,0.01492774,0.01885309,-0.03887508,0.042027242,-0.036866724,0.023126993,-0.05729121,-0.02917059,0.09080958,0.012401226,0.03391985,0.04410824,-0.023765594,-0.075985044,0.046487737,0.110366814,-2.98348e-08,0.09649513,-0.057225656,0.047286507,-0.03403034,0.010775317,-0.0510427,0.015001326,0.015675543,-0.016542584,0.020280927,-0.053504884,0.029642468,0.021840354,-0.017029101,0.00022231054,0.03043141,-0.012802829,0.0985203,-0.014540278,0.03212514,-0.054135963,-0.06740722,-0.10631595,0.035912137,-0.00070218986,-0.15611504,0.026189309,0.034522753,-0.0018009124,-0.029666776,0.09797729,-0.021851942,0.10870139,0.048991714,-0.026311144,0.0010350653,-0.0061292266,-0.06072924,0.010339891,0.038425636,-0.05193617,-0.05779589,-0.023921786,0.029166542,0.0041727293,-0.022792002,-0.0057282993,0.013593326,0.04092435,-0.008419614,-0.015666565,-0.03893581,0.05786875,-0.059935324,-0.028127555,-0.032524846,-0.011449485,-0.015701247,0.024138857,-0.02588938,-0.02915044,0.09882023,0.09122109,-0.026174838 +2.3.1.141,Transfers long-chain acyl groups to the sn-1 position of the glycerol residue.,384,1.0,-0.07862102,-0.06549742,-0.025334684,0.024019472,0.058154963,0.039936453,-0.02569572,0.04108341,-0.004785437,-0.11972995,0.11049957,0.05587797,-0.08030264,-0.016301923,-0.09065223,-0.03355903,-0.019242533,-0.04255588,-0.029784473,-0.03394,0.033917043,0.0012488659,0.0019796435,0.03621173,0.023078833,-0.06976758,-0.094601795,-0.0067874957,0.047769517,-0.09233718,0.06310883,-0.030636737,0.021495787,0.011589581,0.03950051,0.0036016828,0.034733795,0.023548106,0.068535335,0.034230147,0.088969894,0.0056184004,0.038817372,-0.04278759,0.0018384593,-0.032659397,0.010769144,0.024979062,-0.019001056,0.086839505,0.074879006,-0.06798092,-0.024630941,-0.00023317,0.008780182,0.0739725,-0.084557965,-0.007871098,-0.01697583,-0.019459013,0.04578586,0.004243425,-0.03172373,-0.004978615,-0.08721526,-0.050303176,0.115439676,-0.07035452,0.022972504,0.06544745,-0.017002482,-0.07029315,-0.051067375,-0.029475803,0.020999702,0.035680212,-0.06957241,-0.046307907,0.042232256,-0.02655044,0.050968412,-0.024528608,0.08086698,0.02186476,-0.03500915,-0.027268723,-0.0025888889,0.0022808588,-0.013033052,-0.0049666176,0.054776672,-0.065526955,0.033982065,-0.03969571,-0.0110705765,0.05120208,0.07686466,0.036188867,0.0004475917,0.008519451,0.026797231,0.03504544,-0.010660441,-0.052912623,-0.071786866,0.097312525,-0.042124666,-0.005123817,0.04259406,-0.0021865717,-0.018158643,0.06365268,0.07977717,-0.045088675,-0.06432889,-0.012372327,-0.06374104,0.03704639,-0.004362668,-0.044628806,-0.0037284337,-0.010324499,-0.035927683,0.08549438,-0.034231063,0.07989323,-0.027275905,-1.5289232e-33,0.05242741,0.09028327,-0.024759809,-0.027892953,-0.004171925,-0.115064755,-0.078276984,0.020608544,-0.108786464,0.016811423,-0.012059573,-0.024064777,-0.054679886,0.045244746,-0.061641186,0.0021222602,0.027432207,-0.019675659,0.067598134,-0.0624391,-0.013884868,0.003079044,-0.0019171886,-0.056633845,0.05540136,0.029438686,-0.01563381,0.04394759,0.00395017,0.0015685376,0.015645925,-0.05431853,-0.037613355,0.06400309,0.06360238,0.00690604,-0.009792119,-0.021770487,0.07969307,0.04447074,0.046067737,0.059360813,0.0058038537,-0.037131615,0.020806754,0.046670623,-0.081846535,0.08780839,0.02749129,0.057640493,0.008379026,-0.028897878,0.0026539895,0.048814587,-0.051224098,0.015005283,0.026083793,0.030667288,-0.045502245,-0.04616637,0.045759242,0.090196356,-0.029783439,-0.05070525,0.05555735,0.09606237,-0.09227132,0.040761717,0.055601012,-0.05884855,-0.008718593,0.046450302,0.062162507,0.08135928,0.047820013,-0.020026771,-0.0045979507,0.06216654,-0.025675232,0.05127605,-0.091980785,0.031248264,-0.012863956,-0.04494999,-0.07522887,-0.057584435,0.0020482743,-0.06698457,0.005467753,-0.055636227,0.0050652926,-0.032394014,0.07481286,0.028488362,-0.068114325,2.6851491e-34,0.09247155,-0.055872045,0.09759118,0.019950487,-0.06923688,0.020825285,0.04407267,0.05345886,0.008526987,0.05808296,0.04580369,0.07501909,-0.019470176,-0.069470726,0.07446619,0.017725484,-0.0038796095,0.06284607,-0.0010508238,-0.050226063,-0.01903315,-0.025906691,-0.003953832,0.14015907,-0.0051335753,0.021745289,0.030494194,-0.034612544,0.032631032,0.07350092,0.030830413,-0.016092502,-0.024985833,-0.10220755,-0.06845666,0.0021521542,-0.109294586,0.09491726,-0.014667838,-0.013307111,0.08093126,-0.018890444,0.025968684,0.019624455,0.07180666,0.037460577,-0.058106177,-0.028571099,-0.0020926835,-0.10565672,-0.01019245,0.028900325,-0.004996588,-0.016537942,0.081822366,0.1502855,0.078551985,-0.006618714,-0.0009822197,-0.12059889,-0.04463303,0.031408336,-0.009154538,-0.00750228,0.012297001,0.058035627,-0.021603439,-0.06338606,0.07735271,-0.035666995,0.05006067,0.03262489,0.060536627,0.025340008,0.030535817,-0.012771424,-0.064963296,-0.051204495,-0.078777716,-0.048466045,0.027453188,-0.025338136,-0.04156284,-0.013025208,0.051254638,-0.04077251,0.01381637,0.098065704,0.03427403,-0.049191285,0.009658957,0.04121944,0.019476661,0.022056334,0.05109865,-2.1182645e-08,0.05639618,-0.025661165,0.051864997,-0.048749983,-0.07921335,0.09820195,0.0443817,0.027494613,-0.03704768,-0.0881735,-0.08051128,0.056424502,0.015872302,-0.05541123,-0.012514341,0.05241816,-0.087184444,-0.01601399,-0.03456656,-0.029634546,-0.086810604,0.019087426,-0.018236306,0.018513756,-0.071526594,-0.053627796,0.00042242414,0.092300676,-0.05734547,-0.009410286,0.026270583,-0.024869863,-0.067380264,0.104553595,0.045839418,-0.052792177,-0.043272916,-0.048190136,0.031622756,0.045877,-0.013702512,-0.0037648221,-0.0034313297,0.04051121,0.014312677,-0.067004934,0.025366874,0.024738591,-0.04515677,0.1075583,0.01909243,-0.03454198,-0.100612916,-0.05257588,-0.05999098,-0.05549378,-0.0032425767,-0.0077590183,-0.04772558,-0.043226108,-0.029243896,-0.002610544,0.047234904,-0.034475584 +2.3.1.144,"Cinnamoyl-CoA, 4-coumaroyl-CoA and salicyloyl-CoA can act as donors, but more slowly. Involved in the biosynthesis of phytoalexins.",384,1.0,-0.059169497,-0.043080926,-0.075145036,-0.002226221,0.08608201,0.07162062,-0.104282975,0.0009626137,0.10883905,-0.046136323,0.07489801,-0.11361863,-0.021078454,0.048147544,-0.023287933,0.06325058,-0.06075549,0.059461594,-0.09790036,-0.020238955,-0.0017279976,0.04501771,-0.07089498,-0.004091664,0.045665752,-0.043477736,-0.030527327,-0.05334268,0.048694964,-0.029930808,-0.039476097,-0.052253153,-0.019066708,-0.019317424,-0.036687154,0.0905878,-0.08220993,-0.097878955,0.13232103,0.03637814,0.021567062,-0.03717292,-0.048208386,0.037415344,-0.09968781,-0.05846222,0.036757633,-0.026216405,0.07412551,-0.079486765,-0.07083358,-0.014826037,-0.1029865,0.033614147,0.011339008,0.0031273204,-0.054117918,0.0062538725,0.04694714,0.022532126,0.02261341,-0.0006147253,0.024039704,0.007446215,-0.015140171,0.012733694,-0.0049702385,0.01930465,0.06822149,-0.0958615,-0.002009193,-0.044477258,0.027323447,0.03567315,0.070330925,0.08041725,-0.05911204,0.078620784,-0.022568326,-0.002608504,-0.012829025,0.0577031,0.068040006,0.06337154,0.057478666,0.047802597,-0.048382685,0.024726849,0.018645039,-0.0056266207,0.065881796,0.031751435,0.037021514,0.003524248,-0.069074534,0.09181461,0.03196572,-0.011012419,-0.03705181,-0.015504175,-0.024326524,0.07551887,-0.088833466,-0.056163,0.00051897415,-0.030403718,-0.028669711,0.022795724,-0.050629243,0.00990591,0.0155213475,-0.06284938,0.01073673,-0.02576035,0.041298654,0.089310154,-0.07060067,-0.010904196,0.00075067725,0.03201223,0.047126193,-0.02219081,0.049985334,-0.018967418,-0.024225365,0.03519881,-0.0533774,2.8588208e-33,0.027496912,0.045891374,0.035257258,0.08106294,0.035783883,-0.13433112,-0.049306538,0.0044854027,-0.012983912,-0.09194024,-0.028419076,-0.033631276,-0.016735151,0.023414066,-0.027019374,-0.046683382,-0.027609449,-0.110896565,0.06861411,0.059538566,0.013011435,0.014060093,0.02242258,0.072988875,-0.0044022906,-0.015765727,-0.06345222,0.061270546,0.036086924,0.023537762,-0.04872825,-0.03441133,-0.015552597,-0.04733338,-0.016561432,-0.033976097,-0.024287855,-0.049223103,-0.092685774,0.06525252,-0.025654268,0.01933943,-0.06364525,-0.0009364323,0.10635994,-0.009507094,-0.10032023,0.075167194,-0.047758985,-0.009105135,0.013230431,0.030498844,0.090813525,0.045125477,-0.07465006,-0.04507128,0.03109247,-0.065679714,-0.013796977,0.0007536848,-0.010854775,-0.018154468,0.02150187,0.073270395,0.031956874,0.034328748,-0.04451381,-0.027596321,-0.023181112,0.033073124,-0.0020166468,-0.055429235,-0.061613083,0.0036123095,0.018491218,-0.10476224,-0.009807782,0.008852852,0.039299928,0.025924103,0.036476623,0.023579309,0.04672361,0.010376203,-0.0046433527,-0.033047445,-0.028163664,-0.044449855,0.05319108,-0.03148898,0.026029753,-0.026558291,0.027163101,-0.05630656,-0.014575863,-2.5074228e-33,0.13790601,-0.07321723,0.022082537,-0.032250427,-0.054493498,0.07211371,-0.03503551,-0.02651031,0.070532605,0.082668126,0.078426614,0.004210567,-0.01409275,0.032194134,0.0113397045,0.067995,0.04732758,-0.005619079,-0.0031973294,-0.01601324,-0.040668942,0.023068184,0.036598932,-0.044375464,0.07706254,0.06295359,-0.03796395,0.034773268,0.025988944,0.018486034,0.009727837,-0.02402009,-0.038976196,-0.045411084,-0.054611836,0.0706477,0.019334888,0.032542434,0.026046546,0.04822506,0.03692276,-0.016146386,0.05579226,0.03497747,-0.008435445,-0.0033430064,-0.0518433,0.02183465,-0.014072693,-0.070077665,0.047227662,0.10351362,-0.04413936,0.026926339,-0.031167287,0.042638443,0.059848487,-0.030202582,0.063371554,-0.09109445,-0.10448086,-0.05045187,-0.032067,0.020551523,0.07621371,0.010230513,0.008855236,0.0833647,0.036750525,-0.01670241,0.065968476,-0.023276102,0.03108189,0.0043222317,-0.033777755,0.0018338236,-0.051148575,0.011672127,0.020091685,0.0652453,-0.033448726,-0.041684672,0.033163417,-0.076981716,-0.06102349,-0.0962025,0.0846874,0.07487642,0.04557706,0.029996237,-0.022402728,-0.014429575,0.082606964,0.07786057,0.121773735,-3.326898e-08,0.03846876,-0.012553823,-0.04263043,-0.0059640375,0.032309137,0.0022663788,-0.0962865,-0.0036954382,0.042427033,0.07535816,-0.050911643,0.043420274,0.038038354,0.05004981,-0.0014372536,0.037567265,0.013848586,-0.0033003641,0.011109188,-0.07716161,-0.086714536,-0.0051291846,-0.035607196,0.029274011,-0.026457164,-0.090991504,0.02549099,-0.0029609825,-0.03277321,0.05075453,-0.040063325,0.0022624014,0.006721453,-0.058847424,-0.055485666,0.029728016,0.0363657,-0.10340772,-0.0003206983,0.011491577,-0.047927406,-0.060829997,-0.081825286,0.0053902827,0.038856555,0.0046177944,0.015858179,0.01989746,0.010099764,-0.04497668,0.027558835,-0.030748688,0.025513528,-0.03356621,-0.08574462,0.0065079317,0.032101873,0.026093297,0.04298581,-0.11329714,-0.067035116,0.05744363,0.19072329,-0.02350813 +2.3.1.145,"Pyrrolidine and 3-pyrroline can also act as acceptors, but more slowly.",384,0.99999994,-0.01693725,-0.1176332,-0.06564353,-0.0019319912,0.064762,-0.01771096,0.014536421,-0.01246015,0.07714028,-0.01246513,0.07945543,0.034305703,-0.06348545,0.09951208,0.031542446,0.038619135,-0.044297423,0.04227944,0.019019289,0.031203749,-0.056356255,-0.009761715,0.026104609,0.012294259,-0.07396992,0.040352162,-0.043285586,0.04192202,-0.0105134,-0.0907508,-0.049145255,0.040701963,-0.028152246,-0.012693984,0.0069963196,0.029759228,-0.12941046,0.090313055,-0.036358073,0.03194318,0.057852395,-0.08614915,0.055733927,0.012635435,-0.07235455,0.0005332214,0.056263607,0.00063539157,0.0013165325,-0.0638752,-0.027070962,0.046823766,-0.031284172,0.03117978,-0.03857498,0.006623251,-0.07188273,0.018480888,-0.057275664,-0.05766218,-0.054508824,-0.017104775,-0.049263,-0.060241625,0.030500699,0.011719483,0.03330447,-0.0641985,0.020517798,0.048152506,-0.0075173127,0.00013487332,0.02544977,0.014827436,0.07963056,0.008455373,-0.03195289,-0.006984103,0.056283858,0.015541855,-0.051105138,-0.03999994,-0.0070041134,0.038387734,0.049477916,-0.0013282374,-0.09867662,0.0128448475,-0.064002804,0.042734504,0.03813582,0.037452932,0.052473653,0.0038309603,0.01384642,0.0037086096,0.04264498,0.006649806,-0.012102578,-0.031872313,-0.023044065,0.023340784,-0.14862354,-0.015429884,-0.046998274,-0.02162223,0.021880906,-0.03871536,-0.021055074,0.005916744,-0.07633151,-0.053848714,0.068800904,0.045179218,-0.09045174,0.061891247,0.039570283,-0.037259206,0.038910173,-0.0042941812,-0.015890935,0.05830332,0.015205242,-0.0032903566,0.0053022397,0.024891214,0.0047359173,2.2666799e-33,-0.039482456,0.044030603,0.01739185,0.075448915,-0.05614999,0.045456532,-0.079559304,-0.049579803,-0.0081835985,-0.079096675,-0.059949655,-0.06538045,0.037680175,0.09004419,-0.05281108,-0.0808806,-0.028216222,0.0898882,0.042320248,-0.12023509,0.06533441,0.10154628,-0.03139032,0.03594045,-0.024608852,0.024976645,-0.010265862,0.049973086,0.03570726,-0.044150885,0.090549536,-0.004501929,-0.06506735,0.02258282,-0.016771512,0.057292417,-0.010668522,-0.03936526,-0.0055921194,-0.047890067,-0.08494832,0.005110465,-0.075772725,0.052926872,0.017386086,-0.0410653,-0.073408134,0.045679107,-0.06013456,0.06342681,0.047056228,0.004880999,-0.0054268893,-0.051978976,-0.012795769,-0.010984087,0.018071651,-0.0050238613,-0.014504208,0.0010991158,0.014120223,0.09557093,-0.04131874,-0.008271832,-0.037462734,0.014761095,0.0038188417,-0.050280415,-0.0024241009,0.05587268,-0.00075510103,0.0042945235,0.0011374771,0.05017815,0.08005132,-0.04219298,-0.096079014,-0.001846175,0.016831322,-0.03275274,-0.06860857,-0.058989186,0.007963746,0.09762762,-0.08542449,-0.08266841,0.019334896,-0.07870533,0.07901891,0.0035094717,0.0043314532,-0.090622485,-0.021747172,0.031287674,0.072862364,-3.1502503e-33,0.04441306,-0.05921927,0.093740866,0.078850284,0.04812718,0.021750275,0.02705266,-0.042035453,0.12848386,-0.0118012745,0.07433075,0.0013038904,0.01613104,-0.03881394,0.033846196,-0.013658552,-0.0049377843,0.039476614,0.059948295,0.034361262,-0.016321523,0.0038017181,-0.07029812,0.084102914,-0.020279909,0.054582015,0.011450137,-0.029488174,0.024071436,0.030059738,-0.045335855,0.016147068,-0.0118673835,-0.07489539,-0.0035934702,0.021597145,-0.08097029,0.018135104,-0.09034903,-0.062474027,0.04673338,-0.029363966,0.02321433,0.035275623,-0.023673955,-0.004510071,0.07930597,0.0030739815,-0.009775502,0.018941384,0.0016189647,0.055877317,0.007083914,-0.03222799,0.15472613,0.043005902,0.028254703,-0.13040769,0.05795947,0.019171203,-0.022084963,-0.02554586,0.037011497,-0.00063989405,0.032579962,0.004225172,0.0035443024,0.027113402,0.14072694,-0.024502736,0.14646801,-0.0037655232,0.075225465,0.08565745,0.009324669,-0.059997633,0.034184944,-0.0040152776,-0.00444654,-0.039112642,-0.06441876,0.005116345,0.056461714,-0.07392797,-0.025709061,-0.053488575,0.03853767,-0.034640558,-0.0089144595,0.04048695,0.06363621,-0.012913445,0.10874689,0.04130105,0.0269701,-2.6151541e-08,0.026678763,-0.020898202,0.07944302,-0.059256732,-0.07045028,0.007459461,0.07881946,0.037734088,-0.04352558,-0.012520574,0.046734042,0.039400075,0.11135032,-0.05786259,0.109323815,0.022012543,-0.019434197,-0.046802625,-0.040487945,-0.053702194,-0.14440675,0.019047141,-0.056895025,-0.078079015,0.0017387451,0.039291285,-0.009866629,0.011270836,0.0006506746,-0.01658028,0.0226989,-0.02580273,0.0738311,-0.03554712,0.0054754876,0.046272267,-0.0132803405,-0.05513907,-0.01923537,0.010904886,-0.04067476,-0.041003924,-0.07110907,0.00059099175,-0.018481564,-0.019386785,-0.07910139,-0.03333692,-0.05625784,0.0063074413,0.060266957,0.033615362,0.028741015,-0.025183696,-0.08471452,0.09400223,0.0016599989,-0.05129069,0.0033293825,-0.09718028,-0.0038291998,-0.028841289,0.08454359,0.055561025 +2.3.1.146,Not identical with EC 2.3.1.74 (naringenin-chalcone synthase) or EC 2.3.1.95 (trihydroxystilbene synthase).,384,0.99999994,-0.085033186,-0.079255074,-0.05070341,-0.01582256,0.04149559,-0.04092326,-0.038141616,0.045073144,0.062025625,-0.109121144,0.02042092,-0.09294655,0.016442347,-0.029150592,-0.050161663,-0.07862186,-0.033779353,-0.04064583,0.019966824,-0.045028955,-0.015828287,0.013053653,0.03963364,0.049052972,0.046101198,0.012216519,0.06843181,0.03122989,0.003498956,-0.1058369,0.021258214,-0.0051047746,-0.047517568,-0.024969362,-0.009340484,-0.009276729,-0.038453065,-0.06556119,-0.013956615,0.07040007,0.0712829,0.009097311,0.024921797,-0.0058813677,0.017310495,-0.02152172,-0.10624288,-0.012600991,-0.024079392,0.004357166,-0.011610165,-0.06974462,-0.008893295,0.0080952775,0.015221512,0.026200391,-0.10720905,0.012318718,-0.011698683,0.07705818,0.045730785,0.036385838,0.016018858,-0.009720264,0.056910887,0.028258158,0.056189366,-0.12801333,0.042345103,-0.046077553,-0.07208783,-0.026963107,0.011757038,0.08722304,0.022790516,0.07801995,0.004772491,0.022838863,-0.036200233,-0.07689905,0.008570745,-0.030431863,-0.06729574,-0.013177753,0.036374856,-0.004369754,0.04422849,0.03637072,0.0036398987,0.012998352,0.07251491,0.011767857,0.02353767,0.017470332,-0.059351,0.07080936,-0.036138184,0.122397564,0.0087639615,-0.03216128,0.0020182575,0.070828795,-0.06348706,-0.05456762,0.012833519,0.011100838,0.057785984,0.0074895495,0.012308968,7.549353e-05,0.010512787,-0.04728362,0.048519276,-0.012812005,-0.03859115,0.10885207,-0.0009998027,0.0073705367,0.044678144,0.06695225,0.0592042,-0.0475848,-0.00027157945,0.018578874,-0.061929714,0.027247023,-0.08701668,2.5933483e-33,-0.005833389,0.08975386,0.022641916,0.045118313,-0.007785894,-0.007659833,-0.14363138,0.07854998,-0.07684951,-0.08915866,-0.06908852,-0.0005754806,0.010700933,-0.018604932,-0.047567304,-0.052521247,-0.0011531533,0.01600148,-0.04577442,-0.05597694,0.02285935,0.07091264,-0.026796067,0.03342756,0.03110361,-0.014305118,-0.011940241,0.022060338,0.04054694,-0.024056753,-0.008645874,-0.08458735,0.04919816,0.031369086,-0.04304745,-0.018515272,0.0036508434,-0.08009503,0.027709235,0.062540084,-0.008595397,0.052677684,0.079236075,-0.06070648,0.049206465,-0.037376106,-0.076919094,0.050108112,0.081137896,-0.040226124,0.0006679922,0.040403027,0.06620562,-0.022489116,0.019546954,-0.018847527,-0.0019489925,0.018747257,0.102477245,0.060431164,0.022930983,0.16103306,-0.044169616,-0.05515254,-0.024650069,0.12717116,-0.041198704,-0.04250261,-0.009332523,0.035417266,-0.04101829,-0.02181877,0.0650776,0.04502108,0.13591948,-0.054786976,-0.11281518,-0.023854172,0.018007072,-0.0009109218,-0.09554989,0.0425335,-0.018024586,0.055906154,-0.08829427,-0.04700056,-0.021188794,0.039017677,0.04974122,0.06519676,0.05196685,0.008015935,-0.04842996,0.00058096973,-0.022451242,-1.4185273e-33,-0.005578014,-0.017156072,-0.036369875,-0.03245824,0.007775828,0.031271555,0.03397523,-0.022621864,0.07697128,-0.025410974,0.21876365,-0.048802145,0.013441397,-0.12011917,0.058373053,-0.008569941,0.023475954,-0.011453592,0.006874147,0.013631719,0.04362554,0.035447303,-0.037752695,0.06117147,-0.0051656608,0.036628503,0.043956395,0.062276628,0.0652183,0.026124354,-0.07177919,-0.031421103,-0.03946705,-0.01915867,-0.087509274,0.039303396,0.046887442,0.005286628,-0.06172122,-0.07054886,-0.036818102,0.0049847215,-0.017111227,0.083863854,0.07636785,0.061089396,0.027591232,-0.049093064,-0.004305215,-0.013781436,0.018507274,0.0023365344,-0.022827134,-0.013791141,-0.003522179,0.016931247,-0.0010463692,0.033803567,-4.559296e-05,-0.013409935,-0.023185875,-0.025868744,0.04660233,-0.06977164,-0.01293649,0.06576238,-0.09109086,0.11114799,0.047231533,-0.025148286,0.06566596,-0.006828814,-0.033878326,-0.038982794,-0.084085345,-0.057503317,0.044985183,-0.010953044,0.025868522,-0.06444369,0.0218237,0.017364496,0.0021774974,-0.0026075882,-0.041954502,0.05642971,0.013458518,0.043776035,0.004285333,0.039998807,-0.0190724,0.026984988,-0.12519845,0.007619893,0.036792707,-2.8879505e-08,0.046999548,-0.024421804,0.0453422,0.0005297939,0.059473936,0.014522977,0.0006288325,0.010726886,-0.009399697,0.034495335,-0.017557088,0.03895637,0.029124036,-0.04305248,0.01347082,0.029932082,-0.047275636,0.09000329,0.011437288,0.018803978,0.0207085,0.06816893,-0.07755291,-0.051208183,-0.03298682,-0.015536769,-0.02314835,-0.0023125757,-0.021020839,-0.069315724,0.028676279,-0.0059428266,0.07694554,-0.0026193662,-0.005083382,-0.0467267,-0.065729976,0.042330533,-0.015997346,-0.0016643383,-0.018428657,-0.029605381,-0.05255367,0.050987203,0.049494717,-0.031735525,0.050642572,-0.059548292,0.04405698,-0.03294165,0.0595857,-0.024397563,0.059636816,-0.070740044,-0.029544821,-0.058906615,-0.10063556,-0.08966966,-0.014096662,-0.023923416,0.04800018,-0.08969354,0.15909629,0.082787685 +2.3.1.147,"Catalyses the transfer of arachidonate and other polyenoic fatty acids from intact choline or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.148 glycerophospholipid acyltransferase (CoA-dependent) in not requiring CoA and in its specificity for poly-unsaturated acyl groups.",384,1.0,-0.112870455,-0.10575292,-0.099387035,0.056819156,0.07952629,0.027252175,-0.07691548,0.037284255,0.014350381,-0.094625734,0.06175495,-0.009673303,-0.100905485,-0.023499802,-0.061788104,0.032675903,-0.040763505,-0.01788028,-0.028143598,-0.035799563,0.02659425,0.0037837143,-0.021759681,0.013871187,0.06372559,-0.030198628,-0.02476978,4.85375e-05,0.03821884,-0.02971682,0.014790709,-0.014135348,0.021999441,-0.025177877,0.030000476,0.069438525,-0.006852849,-5.0083923e-05,0.006227006,0.024384512,0.07330786,-0.08211795,-0.021389144,-0.015989216,-0.06287975,-0.068065524,-0.033661433,0.014950356,-0.025298264,0.020066857,0.029238498,-0.031655256,-0.11862099,0.006344495,-0.035834514,0.083441705,-0.09210517,-0.03293899,-0.07586384,0.013308516,0.018268153,0.030502291,-0.033975992,0.021101484,-0.10135722,-0.06973095,0.058802053,-0.0761819,0.09966062,0.036107786,-0.047927283,-0.056394752,-0.0056874817,-0.004055448,0.01676013,0.027963009,-0.0137586435,-0.016591502,0.026047908,-0.048552003,-0.024147386,-0.011652151,0.004387032,0.018872114,0.019294662,-0.0046349927,-0.065124385,0.052913513,-0.072808325,0.010445102,0.010136961,-0.03995211,0.09672927,-0.026946928,-0.04008206,0.053393185,0.10857505,-0.034297183,-0.007967237,-0.006604404,-0.013971199,0.04859985,-0.0249251,-0.092472166,-0.024494272,-0.002801847,-0.0437856,-0.03019825,-0.029537028,-0.022738,-0.018660346,-0.011795131,0.0989721,-0.02895912,-0.016320258,0.072097406,-0.08991965,-0.029579055,0.06341478,-0.011771684,-0.043849036,-0.0025569575,0.05474019,0.04962372,0.040222477,0.05107318,-0.019469157,4.4583624e-33,0.042268395,0.07666736,-0.028913533,0.0036709453,-0.046723295,-0.06456346,-0.06803394,0.074524574,-0.030436259,0.04915041,-0.008820444,-0.03056134,0.013657089,0.07908539,0.01731205,0.038206957,0.03244117,0.011682274,0.05972285,-0.029238794,-0.053920273,0.030033728,0.0013770653,-0.037637252,0.0019545453,0.015815733,-0.04709637,0.010631333,0.008876936,0.039397504,-0.0010310874,-0.06596245,-0.024352858,0.023343321,0.00993984,0.06954781,-0.025527403,-0.054727416,0.00051672343,0.06477695,0.040430058,0.039428975,-0.024250463,-0.030561196,0.047048956,0.040850233,-0.104207315,0.0347235,-0.024224294,0.00817059,-0.011302058,0.007717303,0.11213912,0.054346476,-0.027917506,-0.041615967,0.02561672,0.049324032,-0.05818857,-0.020272052,0.02768156,0.083256245,-0.04890331,-0.04074273,0.034943502,0.056419503,-0.07005689,-0.05818943,-0.07316516,-0.029842287,0.047375865,0.017087393,0.016687283,0.12563063,0.048541926,-0.025566326,0.040660962,0.095247865,0.011307984,0.03682347,-0.034772437,0.09001598,-0.01274571,-0.06020956,-0.071807176,0.014470824,0.0060089845,-0.08155068,0.028464789,-0.024583291,-0.041992843,-0.0423173,0.002320539,0.028805483,-0.027433136,-5.656108e-33,0.026533121,-0.082480185,-0.009430692,-0.057179846,-0.039698377,0.075559676,0.047439188,0.026847601,0.10657827,-0.012676051,0.0464975,0.020785391,0.054990284,-0.06598466,0.046006713,0.02083198,-0.06677269,0.0119347805,0.029556645,-0.0076355273,-0.014131694,0.050057177,0.03261266,0.13490818,0.029666113,-0.013911527,-0.0013486103,-0.0023426188,-0.040339887,0.059255946,0.05236486,-0.053120658,-0.07974784,-0.07417747,-0.08645106,0.052506305,-0.074630536,0.101149574,-0.09075043,0.054878376,0.02220187,0.021035044,0.08579591,0.008141341,0.06836558,0.0057915715,-0.059669808,-0.04430936,-0.008773197,-0.1119981,-0.011340686,0.016102409,0.01802343,0.046268694,0.057694133,0.16952579,0.045211907,0.0006315786,-0.0017378832,-0.15534234,-0.07629369,-0.017347123,0.0025671495,0.022556644,0.04458667,0.08077265,-0.037902247,-0.04010908,0.028236575,-0.04710743,0.07174006,-0.005393908,0.00312532,0.07803254,0.019360999,-0.017981814,-0.018873697,-0.059816547,-0.08410062,-0.069510065,0.006978834,-0.0124454815,0.019498577,-0.023985997,-0.03383652,-0.023599459,0.025415616,0.06285451,0.0070873965,-0.020103524,0.01980871,0.040970698,-0.092329636,0.04607362,0.08254897,-4.06623e-08,0.042325415,-0.03791722,0.0067858845,-0.023406131,-0.0148051875,0.045419134,5.0291976e-05,-0.0069059506,-0.0013863888,-0.03234445,-0.125988,0.11006156,0.055411767,0.0035216343,-0.05199065,0.11512983,-0.012116948,0.0070552304,-0.009707466,-0.11394585,-0.04890769,0.018374084,0.02210828,0.0062655564,-0.034286894,-0.017151967,0.017023714,0.04830368,-0.013267595,-0.010062888,0.033934798,0.028341845,-0.0046565244,0.059326343,0.096369885,-0.001314936,0.006255838,-0.072515786,-0.023024287,0.076647654,0.007944655,0.048782427,-0.020309804,0.05197717,0.04814874,-0.023404555,0.026370114,0.021928377,0.023826309,0.004433357,0.011452517,-0.029448265,-0.0689674,-0.08373384,-0.06130597,-0.098644435,-0.052382693,-0.0021250013,0.012923837,-0.036468953,0.011912832,0.054724522,0.15298128,-0.013745353 +2.3.1.148,"Catalyses the transfer of fatty acids from intact choline- or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent) in requiring CoA and not favouring the transfer of polyunsaturated acyl groups.",384,0.99999994,-0.08896018,-0.1124866,-0.08761658,0.05382479,0.08270574,0.029155398,-0.06922973,0.026303971,0.006473521,-0.09987325,0.063948736,-0.023941156,-0.07333644,-0.021610584,-0.058103584,0.015811928,-0.034158107,-0.052162603,-0.036264054,-0.034596838,0.008781327,-0.016041745,-0.030812679,0.0078889625,0.053121924,-0.014476174,-0.035181202,0.004461945,0.03437864,-0.052908182,0.019149574,-0.013821663,0.010945921,-0.03455138,0.020361735,0.046967585,0.003299199,-0.00017122638,-0.0048860395,0.022057485,0.07477011,-0.09443645,-0.021195626,-0.0152663775,-0.06810935,-0.056261674,-0.035692524,0.020961618,-0.02216083,0.01019476,0.021270035,-0.049134895,-0.1102948,0.027794335,-0.024791317,0.07571868,-0.08410023,-0.023597332,-0.06986918,0.011178875,0.01931589,0.052432947,-0.027098082,0.018214125,-0.080171205,-0.094804116,0.04659111,-0.0850736,0.08349468,0.044907566,-0.043094426,-0.07101644,-0.0081952205,-0.004596976,0.031084036,0.019150674,-0.025388869,-0.01379642,0.029595343,-0.04072262,-0.030780412,-0.027372994,-0.0058671185,0.028076943,0.008336988,0.008107652,-0.0668733,0.039913293,-0.06756112,-0.011430983,0.007704379,-0.05056943,0.08942178,-0.030123085,-0.044408675,0.047620796,0.07953193,-0.0274067,0.0018922231,-0.0060401573,-0.009081952,0.036352865,-0.022763923,-0.08329112,-0.031114023,0.0065104724,-0.023865353,-0.041394047,-0.021119023,-0.030414272,-0.021098638,-0.0048941104,0.11187273,-0.0007399409,-0.011688334,0.08041948,-0.091470465,-0.026939994,0.05963439,-0.018165957,-0.040546604,0.013392442,0.05966853,0.049820643,0.03056637,0.04456785,-0.02366299,3.7807987e-33,0.025285063,0.07368264,-0.023061888,0.011251989,-0.038525358,-0.08639482,-0.063037775,0.066521965,-0.010640244,0.042361323,-0.01122837,-0.021198926,0.021668777,0.07840242,-0.007012779,0.012627566,0.035775192,0.024446614,0.07250094,-0.029175684,-0.052219845,0.030422183,0.011032073,-0.03736893,0.021456154,0.02506778,-0.049886394,-0.0031542506,0.042159185,0.045733184,0.0059213596,-0.054492764,-0.033380758,0.028025694,-0.010042372,0.054385185,-0.019254236,-0.042676665,0.01639025,0.048822835,0.040345296,0.031894863,-0.029174836,-0.026813677,0.032355953,0.049659196,-0.12191515,0.031069638,-0.022791449,-0.0038499252,0.003998842,-0.025819682,0.107467204,0.023046508,-0.01579735,-0.023234842,0.032557525,0.05290946,-0.056231763,-0.0027800489,0.011226199,0.094718486,-0.054140523,-0.04796947,0.052839633,0.06203429,-0.07679216,-0.071461745,-0.082806535,-0.014674654,0.019039454,0.043198567,0.014619471,0.11794652,0.04017876,-0.036604766,0.043418057,0.08196775,0.017251255,0.04128209,-0.029715875,0.08202623,-0.022542685,-0.077457696,-0.06796384,0.006991928,-0.013509651,-0.07981765,0.03005972,-0.009722999,-0.025489382,-0.038329825,0.010596785,0.026125608,-0.023942625,-5.053829e-33,0.032893073,-0.09119805,0.011320619,-0.04888284,-0.02795675,0.0849678,0.06302349,0.024532396,0.11892129,0.0011545125,0.045541078,0.02995844,0.043422006,-0.06518633,0.03952938,0.017730309,-0.06012525,0.0010969982,0.022464996,-0.038443014,-0.023194121,0.057608023,0.042501792,0.14719272,0.024235107,-0.012676341,0.00089815597,0.0065808506,-0.030840877,0.06331807,0.04966801,-0.08009091,-0.07220292,-0.07359417,-0.07330957,0.064730704,-0.055145733,0.12342026,-0.08863143,0.046875227,0.00891107,0.015101606,0.083521806,0.0053275037,0.06439566,0.0010598226,-0.07397537,-0.04794365,-0.0059810434,-0.10091049,0.0009848395,0.012420385,0.00760848,0.019788485,0.06388068,0.1831643,0.06370107,0.010706413,0.010762188,-0.16088574,-0.080781594,0.0025344396,-0.007088447,0.004004853,0.033374276,0.080060646,-0.047366563,-0.0478904,0.04599954,-0.04414544,0.072222315,0.008217686,0.017013228,0.07306876,0.023037354,-0.014861905,-0.010028617,-0.05639162,-0.08180323,-0.06565023,0.0018747293,0.0063702567,0.025643008,-0.03137763,-0.010589439,-0.00354253,0.030171325,0.06684469,0.01646966,-0.042057056,0.0135642,0.041300844,-0.06406179,0.030162858,0.08656478,-4.0028784e-08,0.046291884,-0.051609542,0.021488953,-0.0050411345,-0.02273373,0.061373256,-0.008528733,-0.013895065,0.010545952,-0.048633818,-0.12990339,0.13460733,0.06638992,0.007504035,-0.05315669,0.09434765,-0.014077129,-0.0022860935,0.00069842546,-0.13338093,-0.029984,0.015532101,0.020786274,0.015491983,-0.029762885,-0.037474915,0.009991698,0.052602794,-0.024278518,-0.016982883,0.030306533,0.028579907,-0.018337753,0.06754061,0.10416888,-0.0149758095,-0.00070835836,-0.06380364,-0.030780964,0.08197534,0.024113357,0.06603396,-0.027195236,0.025941644,0.037808,-0.008137407,0.025829518,0.020303125,0.025509482,0.011903683,0.010653883,-0.016183896,-0.05526481,-0.046987,-0.05780376,-0.09447674,-0.06754208,-0.010692934,0.014928725,-0.03187769,0.0121800685,0.0655392,0.1551636,-0.0048863674 +2.3.1.149,"Catalyses the transfer of the acetyl group from 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the sn-2 position of lyso-glycerophospholipids containing ethanolamine, choline, serine, inositol or phosphate groups at the sn-3 position as well as to sphingosine and long-chain fatty alcohols. The organyl group can be alkyl, acyl or alk-1-enyl (sometimes also collectively referred to as 'radyl').",384,0.99999994,-0.038509212,-0.10109269,-0.13257487,0.052809946,0.09615319,0.050044216,-0.054095887,0.017162137,0.014865069,-0.07504326,0.07029065,0.009574437,-0.102339804,-0.017093217,-0.04504022,0.06067141,-0.044164922,-0.037689503,-0.0109155355,-0.05931191,0.05899412,-0.033042558,-0.008690608,0.01903098,0.06871795,0.03101406,-0.022322105,0.033529226,0.018372273,-0.049478427,0.054795757,0.023194488,0.013405841,-0.05650801,0.039541278,0.045610774,0.0003000411,0.01676467,0.041080773,-0.0063429098,0.06906113,-0.07186157,-0.02037819,0.016858267,-0.045267288,-0.016243715,-0.06607825,0.07633269,-0.013507331,-0.00022025425,0.021470217,-0.054137696,-0.091173455,0.016729167,-0.039051063,0.042321168,-0.101524785,0.014955718,-0.04306804,0.014941688,0.019934371,0.031360723,-0.03807089,0.05525466,-0.08296925,-0.09261899,0.01368412,-0.048313174,0.056188133,0.050475866,-0.013709464,-0.10588019,0.0030299325,0.017919792,0.03335321,0.005590565,-0.0055948016,-0.024858031,-0.0030197254,-0.02212472,0.014351479,0.010967151,0.030794699,0.07160104,0.024134675,0.030619614,-0.05917522,0.025213469,-0.050634027,0.013179807,-0.0051284763,-0.077467784,0.036614325,-0.057631303,-0.02393449,0.041697927,0.0688398,-0.05466356,-0.027808126,0.023638858,-0.0029225007,0.020228233,-0.004639286,-0.10052602,0.0063243997,0.037644684,-0.0036563422,-0.018096782,-0.007898066,-0.010989077,-0.03122226,-0.014646362,0.085480504,-0.060020223,-0.043030266,0.045681164,-0.05014493,-0.010355545,0.04657512,-0.047976557,-0.011386417,0.022264324,0.02475736,0.03812738,-0.015446024,0.08282657,-0.0072624944,3.2822653e-33,0.02146367,0.045793395,-0.04383094,0.016942162,-0.033536393,-0.09135264,-0.012740967,0.027067143,-0.040702164,0.05527,-0.034382973,-0.03293823,0.01954378,0.07270267,-0.008727328,-0.0031612958,-0.01959098,0.019222878,0.06598857,-0.012328832,-0.054253373,0.02970737,-0.0082362695,-0.016076108,0.01204759,0.0019425154,-0.04337166,-0.019885836,0.0072549796,0.015587249,0.021830175,0.009685408,-0.060323823,0.00021794577,-0.04548756,0.045724645,-0.040142182,-0.08701591,0.060320634,0.030751904,0.032342605,0.034290344,-0.028611418,0.0047781337,-0.03025303,0.051617533,-0.14590661,0.04477976,-0.0049463245,0.00013216739,0.031477895,-0.053888574,0.108184636,0.04744145,-0.056503113,0.0012494925,0.024363626,0.0030363444,-0.018785238,0.012229459,-0.020995883,0.06344677,-0.016376056,-0.055003893,0.055733856,0.028614827,-0.054799207,-0.075415954,-0.07183639,-0.030205697,0.014762191,0.04687084,0.055799033,0.0909781,0.015862003,0.001768574,0.039662536,0.034062933,-0.042920183,0.047153942,-0.009761031,0.03096924,-0.025086412,-0.042913876,-0.056926504,0.010060159,-0.03094895,-0.10771592,0.010768232,-0.02678842,-0.062320292,-0.03584447,0.023942428,0.080966085,-0.028055154,-4.8513016e-33,0.023580227,-0.10880226,0.024231303,-0.043218438,-0.030447626,0.06477356,0.04705484,-0.012885222,0.072361045,0.05193895,0.03152937,0.010907425,0.0029756234,-0.04227239,0.022227762,0.02228502,-0.035028517,0.009337623,0.058930323,-0.049343128,-0.0034771254,0.10166227,0.022089517,0.18990144,0.04119072,-0.027619481,0.00341525,-0.035645068,-0.012176142,0.07581454,0.044914618,-0.09995102,-0.010486079,-0.051412966,-0.061539687,0.095704414,-0.06339607,0.098965555,-0.091415614,0.022583121,0.02029804,0.044281814,0.048432473,0.0074150274,0.0551622,0.014193315,-0.06548679,-0.017990856,-0.043756314,-0.06995392,-0.005303898,0.008961334,-0.013093285,0.038367458,0.052231535,0.16166544,0.051388882,-0.017886791,-0.032808922,-0.10210285,-0.086562544,0.024987368,-0.0076185907,0.00760699,0.07723298,0.05791269,-0.058068287,-0.055698555,-0.00049271795,-0.053053055,0.061400317,0.028443288,0.0037465286,0.114164434,0.010662994,-0.056934983,-0.025225434,-0.090512924,-0.10123931,-0.08173966,0.022941139,-0.0059335185,0.011407411,-0.004958259,-0.05884608,0.0039987145,0.02518397,0.07393794,0.0075753354,-0.011666721,0.04981802,0.038898025,-0.08685496,0.037731588,0.059398264,-4.2123773e-08,0.04555467,-0.05105856,0.05090361,-0.03855187,-0.070393935,0.008290061,0.07564069,0.01730292,0.029379638,-0.07734888,-0.07403599,0.110236585,0.058736056,-0.043302152,-0.0014165405,0.12899852,-0.03311812,0.012990028,-0.005177273,-0.13945237,0.01561587,0.0017079827,0.039809458,0.016642356,-0.017808843,-0.05786034,0.0141826365,0.095082715,-0.012154582,0.0024175486,0.016999438,0.0014063304,-0.041824494,0.044675063,0.09370401,0.022930114,-0.049677223,-0.0918564,-0.012828256,0.056337196,-0.046102133,0.027649099,-0.0054417667,0.02082928,-0.017874693,-0.008757822,0.044307206,0.020206116,0.062325075,0.005663559,0.0099250935,-0.002350651,-0.05078678,-0.04400246,-0.095241636,-0.06490219,-0.059300803,0.0055944324,0.057572,-0.061700445,0.0015721271,0.07188574,0.17646347,0.027847596 +2.3.1.150,"The enzyme is present in the poppy, Papaver somniferum. At pH 8-9 the product, 7-O-acetylsalutaridinol, spontaneously closes the 4->5 oxide bridge by allylic elimination to form the morphine precursor thebaine",384,1.0,-0.013165097,-0.029317467,-0.06500969,0.023202602,0.028240591,0.064288914,-0.088013455,0.056761462,0.036095463,-0.0018675824,0.04379044,0.013992221,-0.06758129,0.0058304234,-0.055818837,0.05502945,-0.047566347,-0.013100458,-0.0016716465,-0.010438547,0.12484546,-0.0003980293,0.045526795,0.01226032,0.008023786,0.04810004,0.056578267,0.0059539615,0.013023731,-0.13038701,0.072603926,0.020667192,0.007324937,-0.029518208,-0.029517857,0.039271224,-0.04803578,-0.005410054,0.13144206,0.011707647,0.06493204,-0.09344809,-0.083437905,-0.027338387,-0.0019462894,-0.034761336,-0.036302444,-0.02020953,0.04339965,-0.028548138,0.023367548,-0.06978246,-0.023760568,0.05729353,-0.013649379,-0.048075244,0.0211644,0.030992106,0.003916346,0.024318978,-0.0005822186,0.07598914,-0.0071515623,0.017527774,-0.014639318,-0.011557181,0.026000163,-0.034128077,-0.041379474,-0.011456813,-0.010809396,-0.033419862,0.11426272,0.013032234,-0.010694685,0.017169798,-0.029906051,-0.024482843,-0.00967236,0.0048045022,0.1119033,0.0399266,-0.035942998,0.10292044,0.024195261,0.014863,-0.01766906,0.02864145,0.05533009,-0.03114087,0.0417821,0.028240312,-0.115768164,0.026143696,0.011524839,0.009439647,0.03166592,-0.03641658,-0.04478273,0.0004302647,0.0141280545,0.039924517,-0.09060273,-0.062261164,-0.048094414,0.029770954,-0.029154265,-0.0062001715,0.04204811,0.021088159,-0.03421309,-0.078903355,-0.012241626,-0.026684431,-0.06880314,0.029407216,0.0063339286,-0.033703193,-0.01924694,-0.10652613,-0.0044483272,-0.0047356733,0.015850442,0.08484891,-0.023133576,0.01837391,-0.0699467,6.8940416e-34,0.050464984,0.030811833,-0.024354128,0.024450712,0.0021770473,-0.05774326,0.01057487,0.020377133,-0.021194465,-0.11486318,-0.08939718,-0.09986529,-0.032498244,-0.02226027,-0.016270045,-0.056628842,-0.0030896666,0.0038126437,0.012452888,-0.069700375,-0.038663592,0.024781192,-0.07061074,0.045579474,-0.012400897,0.09828148,-0.03829606,-0.068651,0.10416841,-0.014005849,0.023313772,0.02266032,-0.07826578,6.0828737e-05,0.058517575,0.03296542,-0.014965654,-0.04781448,-0.042420194,-0.0066101877,0.008735421,-0.014326278,0.07543137,0.017886925,0.0036353779,-0.07913971,-0.07126665,0.05879601,0.14271536,0.080249906,0.038259942,-0.039593022,-0.01737556,0.021929614,-0.081202894,0.036212638,-0.09352551,0.002396837,0.06685379,0.010147201,0.044612307,0.011991546,-0.0019343799,-5.4225122e-05,0.0028416,0.04002977,-0.049868315,-0.059996754,0.0030506977,0.108197264,-0.06046878,0.020422729,0.009912394,0.061553247,0.04746086,0.085168526,0.0024091352,0.054089833,0.06873566,-0.018070944,0.02215223,-0.094580345,-0.04822465,0.011028137,-0.026471863,0.006336331,0.043818463,-0.010843624,-0.038674098,0.11182436,-0.0061078086,-0.07111576,-0.055076383,-0.013166977,0.006266335,-1.9134741e-33,0.090001896,-0.049529456,0.034749474,-0.025894955,-0.03914038,0.06605686,-0.03290015,0.015552705,-0.047824726,0.1229794,0.051858794,0.037728205,0.13277206,-0.048965015,0.0041486914,0.020914797,0.012501544,0.072806425,0.018742025,0.013619482,-0.009696929,0.10150956,-0.04338485,0.06564784,0.060115058,0.01861486,0.036878973,0.039052594,0.031937804,-0.005105655,0.06456255,-0.03294424,-0.057353992,-0.031915903,-0.051487774,0.13540034,-0.007683439,-0.008891185,-0.05299697,-0.016421372,-0.053704217,-0.07505565,-0.004578793,0.0153361615,0.028444031,-0.026708117,-0.044310667,0.046553172,0.11031803,-0.005788891,0.042921774,0.049258735,-0.036359698,-0.042926926,0.0019223602,0.0062842066,-0.0271057,-0.061027355,-0.051230963,-0.12211926,0.015729444,0.03052876,-0.012432241,-0.036251243,0.03296379,0.032892074,-0.024058297,0.014464817,0.020475984,-0.001973459,-0.02657517,0.021162068,0.0036858409,0.015886437,0.03481215,-0.0822534,-0.07222749,-0.047504622,0.030681059,-0.027180335,0.002304594,0.00054837414,0.04395796,-0.088121794,-0.048789002,-0.049688566,0.088043146,0.12131537,0.0070307264,0.024509083,-0.005790967,0.022261484,-0.08780569,0.018982807,0.010160704,-3.4062094e-08,0.030321652,-0.049300153,0.08362419,-0.06463556,0.016873939,-0.029775364,0.04770753,-0.026531052,0.0112451725,-0.06336197,-0.023883395,0.056202263,-0.027309565,0.0424991,0.04264262,-0.037544902,-0.07484711,0.072177194,-0.025734758,-0.017726727,-0.065091416,-0.03222272,-0.05577116,-0.05876799,0.0730171,0.0071474425,0.049024865,0.027558537,-0.028310867,0.031201521,0.11946809,0.008809326,-0.025970478,-0.040222883,-0.05730963,0.09223171,0.024525233,0.016358403,-0.031079188,0.02171477,0.002721658,-0.058039702,-0.056904305,0.059855033,-0.011378922,0.016268764,0.0043986253,-0.022010315,-0.027372066,-0.022252442,-0.0033853308,-0.005335231,-0.01673026,-0.068125576,-0.09857244,-0.08616485,0.0032944805,-0.055677295,0.004788104,-0.08451178,-0.00347304,0.010146846,0.22989483,0.071177386 +2.3.1.151,"Involved in the biosynthesis of plant xanthones. Benzoyl-CoA can replace 3-hydroxybenzoyl-CoA (cf. EC 2.3.1.220, 2,4,6-trihydroxybenzophenone synthase).",384,1.0,-0.09914911,-0.027345313,-0.02467705,-0.086640425,-0.00297618,0.06364974,-0.06673891,0.00024862023,0.06898943,-0.015324999,0.10135956,-0.101588614,-0.0420343,-0.07366804,-0.070997074,0.035174582,-0.029150117,0.07138863,-0.06225734,0.009883734,-0.007973247,0.11582357,0.04126866,0.0054055294,0.08553607,0.058165684,-0.048284825,-0.0054288865,0.06334066,-0.047577232,0.016347796,0.08978662,0.08760692,-0.039929584,0.036813408,0.041866638,0.001196626,-0.10971,0.06251997,0.038730495,0.050956164,-0.0619475,-0.0148861185,-0.027995488,-0.045596723,-0.06865327,-0.033597715,-0.024383722,-0.0074458714,-0.009829939,-0.02471596,-0.031987444,-0.04301918,-0.0030794856,-0.066874,0.03649341,0.054415636,0.07410525,-0.05766984,0.05760855,0.049201395,0.061781343,-0.015083933,0.029276684,-0.055308737,0.002900822,-0.069210015,-0.012966891,0.022723522,0.010043836,-0.0808246,-0.054060474,0.025514934,0.0027014094,-0.056985915,0.06873505,0.06622072,-0.010622449,-0.030227914,-0.04124014,-0.019782163,0.02187436,0.018547403,0.042792983,0.028098386,-0.0021867256,-0.015025301,0.04565186,-0.03834069,0.046585508,0.028593935,0.036843374,0.04367396,0.020785365,-0.10026628,0.124435894,0.08989381,-0.016408857,0.08293991,-0.030854812,0.03399737,0.025155647,0.022298358,-0.07999063,-0.028796643,-0.034860883,-0.076288976,0.049065407,-0.03383,-0.07888536,-0.04763198,-0.076494806,-0.029270176,0.015549647,-0.029314913,0.027798332,0.036411755,0.0067271246,-0.017591892,0.0360039,-0.0023944087,-0.05219226,-0.01558832,-0.0011801571,-0.025688525,0.015981635,-0.07186083,1.5082204e-33,0.0694306,0.14634115,-0.001606753,-0.026882043,0.016002307,-0.03917193,-0.056268882,0.06672111,-0.023256702,-0.032386605,-0.02379315,-0.017491825,-0.03520518,-0.047646005,0.022425612,-0.026103891,-0.058407128,-0.009502735,0.037853625,-0.017261744,0.014289926,-0.03399584,-0.07142144,0.009638587,-0.020748936,0.050292388,-0.00123784,-0.030035205,-0.017985385,-0.02037635,-0.06253011,-0.029815247,-0.0038205776,0.054655265,-0.09985719,0.008682426,-0.018539408,-0.06545542,0.008814898,0.075690195,0.051058788,0.018317943,0.04644453,-0.013314487,0.07550865,0.0071688974,-0.08891328,0.027100507,0.10784745,-0.020967165,0.03836589,-0.010424546,0.1086477,0.09153711,0.0011077924,0.023350539,-0.0882984,0.04558331,-0.03180394,-0.0051419516,-0.0016661742,0.025335955,0.0035474785,0.06642578,0.021490766,0.014934957,-0.06603592,-0.065275095,-0.07206589,0.028825695,-0.04175354,-0.09655236,0.055548336,0.053595997,0.04612509,-0.037986845,-0.064236216,-0.003948287,0.07068127,0.005638595,0.03324039,0.07458929,-0.0007509234,-0.024090942,-0.034953456,0.0015437657,0.011346093,0.01620828,0.045520835,0.091052264,0.020522395,-0.0973368,-0.029497232,-0.025864352,-0.023870595,-1.8348133e-33,0.045596264,0.007687314,0.021896075,-0.022471208,-0.019769793,0.012130866,-0.016827816,-0.03254784,0.009002843,0.030187527,0.032636892,0.0060059098,0.05365549,-0.0719803,-0.05764775,0.013290768,0.08192736,0.028343529,-0.026287297,-0.046233367,0.0020030388,0.006960305,0.026100818,0.016822794,0.0005545787,-0.007829551,0.02176706,-0.03385367,0.011923638,0.05758821,-0.04179195,-0.020558735,-0.029460773,0.0071380604,0.0404269,0.043553013,-0.06259361,0.06880773,0.021016221,0.057034444,-0.047737863,-0.016963176,0.06600063,0.06375718,0.059132677,0.021817476,-0.03238154,-0.07228136,-0.011573284,0.00049404945,0.042433623,0.06138594,-0.03629517,0.060056455,-0.030494936,0.038551535,0.0074270144,-0.05670058,-0.019809509,-0.024783993,-0.04041458,-0.017444221,0.01466482,-0.060336925,0.0807299,0.05411023,-0.023788707,0.08851702,0.05070112,-0.034464814,0.14761014,0.011539306,0.022473171,0.06176775,-0.08847239,-0.0049859914,-0.0672223,-0.10778722,-0.09904173,-0.066465974,0.0688774,0.035504594,0.027803162,-0.07177639,-0.08842824,0.0108898925,0.0347638,0.11005338,-0.015512184,-0.022098714,0.0036673725,0.05439923,-0.031631388,0.08961098,0.11300284,-3.351304e-08,-0.0426982,-0.04384829,0.0438631,-0.0149025535,0.006657017,0.011122844,-0.0048991335,-0.03861787,0.10042226,0.013605189,-0.07739097,-0.013055848,0.035930853,0.069098495,-0.022018496,-0.03288461,0.028200774,0.05330854,-0.028531302,-0.036147237,-0.037876964,0.050858133,-0.016224867,-0.011114926,0.008701364,-0.12150775,0.0028174953,0.0021354265,0.051894497,0.01782233,-0.024363678,0.06161531,0.02837951,0.07199042,-0.02252438,-0.016562887,-0.011094262,-0.12145157,-0.032626484,-0.0116618285,0.013406921,-0.06837193,-0.08459163,0.05113471,0.06478606,-0.067846246,0.060866743,-0.005006298,0.039825603,-0.032224875,0.014451976,0.031065874,0.011546693,-0.13041328,-0.025749596,0.038218085,0.016829928,0.09989832,0.036865305,-0.014744874,-0.1090212,-0.01449237,0.14379375,-0.06862503 +2.3.1.152,"Acceptor alcohols (ROH) include methanol, ethanol and propanol. No cofactors are required as 1-O-trans-cinnamoyl-beta-D-glucopyranose itself is an ""energy-rich"" (activated) acyl-donor, comparable to CoA-thioesters. 1-O-trans-Cinnamoyl-beta-D-gentobiose can also act as the acyl donor, but with much less affinity.",384,1.0,-0.055875517,-0.091809146,-0.12957865,0.048482146,0.10554129,0.030040598,-0.030761054,0.060919065,0.007194192,-0.07767569,0.04540789,-0.0008455474,-0.12575619,0.06704539,-0.010119291,0.099757954,0.06019517,-0.023431607,0.021201015,0.0027297984,-0.033061303,0.012834541,0.00321153,0.003831932,0.08742872,-0.041136313,-0.014690053,0.014640827,0.032441575,-0.05266695,-0.0064628464,-0.020550167,0.046376362,-0.022959875,0.052626546,-0.015872855,0.01585686,-0.0068732873,0.03675365,0.02648638,0.03350647,-0.037297685,0.068348676,0.07730002,-0.107798785,-0.06297735,-0.018136892,0.044567276,0.033471707,-0.049111232,0.009970521,-0.028956717,-0.069295004,0.09323836,-0.002205041,0.060563385,-0.022491215,-0.06751902,-0.012743272,-0.00906832,0.02384883,0.028445043,-0.083735496,0.008668324,-0.027422508,-0.03130249,-0.001674253,-0.054302756,0.061078936,-0.0047160024,0.001525129,-0.090695955,0.08261989,0.014695514,0.026230542,-0.0320645,-0.015166512,-0.006695526,0.05104864,0.025970517,-0.026903141,0.0034318056,0.037614297,-0.007300229,0.077830724,0.02370266,-0.043774664,0.06288356,-0.026567858,-0.0076804548,-0.047433924,-0.057003736,-0.0018977816,-0.12036358,-0.0100581385,-0.030433172,0.07606725,-0.033390258,-0.004462699,-0.011097024,-0.055749796,0.081194855,0.01892349,-0.065497585,-0.11936525,-0.0013577165,0.023568016,0.055637147,0.0015369419,0.045272056,-0.03879416,-0.020432703,0.12209311,0.009552949,-0.069843784,0.05312476,-0.01144966,-0.052193183,0.02462288,-0.027453395,-0.01116034,0.0022723237,0.06555269,0.047096115,-0.022878796,0.035679102,-0.011856689,5.2417525e-34,0.008034761,0.03395135,-0.047672503,-0.014259836,-0.028873015,-0.029701468,-0.08651949,-0.047468208,-0.024508856,-0.045368016,-0.028641041,-0.003695869,0.03861326,0.1459175,-0.03700311,-0.038135435,-0.016658021,-0.005402679,0.05466912,-0.0044059437,0.0055392166,0.095290855,-0.053605523,0.08208493,0.02687752,-0.01170483,0.007578199,0.07063769,0.03310475,0.004417689,0.001099841,0.04586955,0.01624823,0.03511727,-0.08395529,0.08444258,-0.08785638,-0.096260756,0.013318652,-0.025609234,0.05897016,0.061657287,-0.0206225,0.0018010593,0.058525704,-0.023422722,-0.06363429,0.0033193014,-0.063884154,0.08472783,-0.026348237,-0.045244318,-0.042773638,0.047334082,-0.061037503,-0.044369645,-0.040506132,0.041118998,0.050844222,-0.012667721,-0.049164772,0.028767684,-0.0077106524,-0.03057881,-0.02217458,-0.007811483,-0.027381122,-0.07203473,-0.049745306,0.03418554,-0.031904627,0.010692326,-0.032765653,0.08039282,0.000697892,-0.08430726,0.0454275,0.0048566074,0.046179462,-0.005261469,-0.005568975,0.0072338628,0.0064891414,0.0018252501,-0.03243533,-0.050462738,-0.035264965,-0.015189474,-0.030447684,-0.021437045,-0.005598977,-0.036631007,0.0020041359,0.052325353,0.055562276,-1.1175369e-33,0.100729175,-0.14063059,0.077649795,-0.055609226,0.0057500866,0.09858974,0.021852845,-0.10797865,0.0989733,-0.05475009,0.06829925,0.018120512,-0.01837693,-0.054467775,0.067560166,-0.06909541,-0.042131245,0.0067645293,0.020207997,0.012459301,-0.0042659794,0.11701353,0.06722329,0.003347326,0.07052652,-0.007344468,-0.03926114,0.039018113,0.009354133,0.072563216,0.033561226,0.03638623,-0.039801046,-0.04311017,-0.06925305,0.09955531,-0.050233074,0.06520173,-0.09342655,0.041494325,0.05018019,0.041093804,-0.0709297,0.052505966,0.015190473,0.035409015,-0.072713695,-0.05774383,0.0512631,-0.116852574,0.029258726,0.007895324,-0.045823004,-0.022330401,0.071234964,0.11767351,0.03508053,-0.034240317,-0.015836775,-0.09779305,-0.033300776,0.0439756,0.023079375,-0.051322915,0.03699262,-0.017403679,0.0060291803,0.079851,0.030025946,0.013641861,0.047565915,0.055061307,0.03445957,0.105156094,0.05503643,-0.08635063,-0.07804035,0.009280698,-0.04992684,0.01169207,-0.06668016,0.016079223,-0.0052699954,0.06596828,0.01837969,-0.019482076,-0.012148458,-0.007012294,0.03273205,0.08779027,-0.010231933,0.035189796,0.013595705,0.07378431,0.04394477,-3.9610704e-08,0.06614294,-0.019653127,0.06849524,-0.011348675,-0.091029294,0.025849702,0.0016372263,-0.051319666,-0.05847733,0.02206321,-0.017027728,0.117342524,0.026379306,0.025664033,-0.016356684,0.025057962,-0.04344416,-0.008122711,-0.024375252,-0.030567555,-0.047562435,0.0001345576,0.012128299,0.056478154,-0.047532868,0.010718988,0.04873898,0.07855542,-0.045565803,0.02046844,0.03233072,0.005965225,-0.024378637,-0.005670322,-0.025752254,0.010840183,0.0091077965,-0.042215694,-0.060934514,0.026389608,0.07865129,-0.014093472,-0.06231342,0.012549676,-0.012549358,-0.034845147,0.0041093226,-0.04002944,-0.038634766,0.019817816,0.066647194,-0.035090216,-0.037454423,-0.021364056,-0.06662304,-0.025692957,-0.058191914,-0.031736404,0.031559993,-0.10089164,0.047938455,-0.026831925,0.19297937,-0.010404981 +2.3.1.153,"Isolated from the plant Gentiana triflora. Transfers the hydroxycinnamoyl group only to the C-5 glucoside of anthocyanin. Caffeoyl-CoA, but not malonyl-CoA, can substitute as an acyl donor.",384,1.0,-0.096358046,-0.016745452,-0.111694075,0.03881408,0.07929891,0.08060943,-0.009927621,0.03986117,0.012998708,-0.10246163,0.12169325,-0.120692395,-0.059487898,0.00068327115,-0.04841286,0.006802852,-0.020628324,0.07156418,-0.045121346,-0.02111222,-0.03484537,0.0005159566,0.027200136,-0.011152043,0.037330586,0.013922092,-0.027359195,0.018302344,0.008293262,-0.08835917,-0.007072013,0.07765947,-0.020938408,-0.0048068147,-0.0014059826,0.088510126,-0.021778457,-0.0070558195,0.14156644,0.060922023,-0.008727548,-0.05182687,0.039105136,0.0049912087,-0.040918443,-0.022323493,-0.049840122,0.0023600133,0.08458138,0.028072862,-0.038399063,0.028629495,-0.05146568,0.06480776,-0.013820979,0.00044353376,0.06574334,-0.04940353,-0.008365377,0.073878616,0.100011915,-0.010853563,-0.044081498,0.042557117,-0.116496,-0.01627857,-0.025400817,-0.0045052376,0.109810434,-0.032334287,-0.015791938,-0.061450813,0.045963157,0.0054275077,-0.054170784,0.08507903,0.0013294581,-0.009877754,0.019711621,-0.013651176,-0.019380862,0.035155445,0.045106426,0.0709028,0.020002175,-0.007946257,0.004944948,0.04644395,-0.012886559,0.054631528,0.030743018,0.127877,0.07521406,0.00073581137,-0.08241435,0.0511517,0.081796646,-0.05505071,-0.0341895,0.016323296,-0.031149434,-0.019486504,0.030709378,-0.06277086,-0.122389,-0.027216576,-0.036967568,-0.065141745,0.08692832,-0.027123235,-0.06947505,-0.00054469367,-0.079097845,-0.0072206864,-0.005497752,0.03381398,0.0027351591,-0.05867531,-0.009687918,-0.005129458,-0.052482888,-0.03841719,0.006859787,-0.017362632,0.01950606,0.041297153,-0.03838993,4.6617355e-33,0.046431787,0.06436643,-0.0405788,-0.0018909534,0.0151100475,-0.010359777,0.009460373,0.0026538796,-0.017179588,-0.062576324,-0.094716884,-0.032922808,-0.047104966,0.022700718,-0.10368668,-0.015937602,-0.040748335,-0.06333396,0.088852115,0.0042498107,0.09057707,0.07026079,-0.06090929,-0.022649307,0.0048638238,0.033234697,-0.0010309854,-0.00986019,0.077382125,0.0227236,-0.034052245,-0.07981333,0.020619376,0.025484068,-0.013214934,0.0073021767,-0.057901025,-0.05738868,-0.0054118484,0.120308354,0.014734916,0.016638253,0.06419291,-0.021488626,0.067717426,0.0063767205,-0.08886723,0.06774328,0.010836792,0.030711062,0.042015526,-0.0329283,0.009152913,0.0046043624,-0.0717696,-0.027328108,-0.0783783,0.060655683,0.004454755,0.00029994,0.05611111,0.047738105,0.024972238,-0.03425816,0.044354457,0.061065506,-0.11213362,-0.061370395,-0.0027997994,-0.060731165,-0.0003361013,-0.040775917,0.023968589,0.079562865,0.06808262,-0.013710996,-0.019579455,0.036712475,0.05767403,0.02775003,-0.058275536,0.03109027,0.07993995,0.022115175,-0.00419141,-0.0068874178,-0.022634337,0.050924845,0.012278015,-0.033776306,0.07145398,-0.005849127,-0.006584545,-0.041584443,0.0077476436,-3.379332e-33,0.09423116,-0.04599012,0.01549426,-0.08666221,-0.04734907,0.057435483,0.017254693,-0.039923735,0.011117059,0.07504633,0.059275836,-0.012412164,0.0754211,-0.05394355,-0.043996323,0.0059173517,0.05330553,0.05425248,-0.049150173,0.028427059,-0.042816553,0.030876564,0.005448816,-0.002691454,0.043282263,-0.006402348,0.030648952,0.004217559,-0.018601933,0.034436498,0.015678762,-0.01988082,-0.065670565,-0.026599256,0.049068056,0.044126734,-0.059024677,-0.016476994,-0.047697008,0.0075789145,-0.060508933,-0.027646588,-0.009874128,0.10036211,0.036751617,0.014970996,-0.08195655,-0.033501584,-0.024736572,0.036985505,0.0019225779,0.027456352,-0.041121017,0.009927456,0.0025651504,0.025975807,0.07867895,-0.029151522,0.0005172334,-0.08246076,-0.027227731,-0.03281469,-0.045938052,-0.018462967,0.10013644,0.14169472,-0.048055127,0.08484738,0.023026798,-0.03335912,0.124074414,0.025163148,0.06871834,-0.0010567202,-0.0046252264,0.01485738,0.04666694,-0.049879283,-0.05667585,-0.045453217,0.033816606,-0.017044391,-0.0117475055,-0.04738219,-0.07482495,-0.009831718,0.06337576,0.00069401006,-0.009491569,0.0018919468,-0.027454635,0.065618254,-0.025808232,0.0318375,0.16045257,-3.1703305e-08,-0.001916286,-0.024081994,0.027047973,-0.0022771086,0.044191223,0.033666912,-0.09037975,-0.027535846,0.048207663,0.011976016,-0.072137184,0.06461454,0.016742332,0.0684025,-0.035932362,-0.027919222,0.067124926,0.064184204,-0.008668918,-0.023711849,-0.14189585,0.031697027,-0.026759857,-0.0066975155,-0.0029298146,-0.056166004,0.07637558,-0.061119307,0.06313774,-0.03468782,-0.020360796,0.007899453,-0.09814521,0.026763408,-0.014778196,0.024959192,0.00303141,-0.0087355785,-0.043472573,0.0105595505,0.029971775,-0.012194242,-0.04257793,0.025198948,0.010097851,-0.09752488,-0.03183265,-0.07933147,0.040452644,0.03207358,0.060200978,-0.02820377,0.015501004,-0.07749548,-0.022677835,-0.022459252,-0.005059221,0.021988275,-0.022192506,-0.006693251,-0.13426791,-0.031910982,0.16023834,0.015204267 +2.3.1.154,"The peroxisomal protein sterol carrier protein X (SCPx) combines this thiolase activity with its carrier function, and is involved in branched chain fatty acid beta-oxidation in peroxisomes. It also acts on 3-oxopalmitoyl-CoA as a substrate but differs from EC 2.3.1.16 (acetyl-CoA C-acyltransferase), which has little activity towards the 3-oxoacyl-CoA esters of 2-methyl-branched chain fatty acids such as 3-oxopristanoyl-CoA.",384,1.0,-0.02042536,-0.055250276,-0.044202957,-0.027318936,0.08032619,0.023126403,-0.08817051,0.05725445,0.054653745,-0.09649633,0.08150588,-0.005691703,-0.0009012754,-0.0127325,0.033077724,0.0034402316,-0.048215486,0.012790262,0.10053769,-0.018127825,0.041820616,-0.012962543,-0.0046177297,0.0070823873,0.0051077763,0.030928418,0.0057166885,0.00063437753,-0.016137753,-0.042586364,-0.02330818,-0.05154302,0.06876729,-0.067522086,-0.008593179,0.07129529,-0.04997569,-0.06786045,-0.056977835,-0.034620605,0.0870722,-0.03643423,-0.043259174,-0.010001166,0.03242364,-0.117927484,-0.020710295,0.014913337,0.0010115725,0.023859087,0.036246564,-0.12721543,-0.0023620895,0.018562272,-0.04015628,0.012935811,-0.09653464,-0.03242936,-0.016632684,-0.0140807945,-0.003359368,0.051433783,0.013240821,-0.0014146797,0.022546751,-0.045702014,0.0154686505,-0.049489915,-0.0017932036,-0.02510257,-0.038576312,-0.0012311134,-0.024712507,0.05855461,-0.017894883,0.014869547,-0.039751913,-0.0689821,0.029293444,-0.034209337,-0.0072599095,0.029627524,-0.055925395,0.07799841,0.05002052,-0.015602755,-0.013573014,-0.026259989,-0.110419706,0.1014196,0.04130942,0.031972837,0.005845033,0.029838314,-0.057517353,0.04335804,0.037157167,0.060701806,-0.034172554,-0.06140624,0.052699715,0.12830943,-0.026837891,-0.04740653,0.013972628,-0.027777791,-0.059303015,0.05290997,-0.05701395,-0.040995367,-0.019376963,-0.052425835,0.08243046,-0.034510437,-0.018322824,0.08847357,-0.0058109825,-0.043874577,-0.026451558,-0.014052119,-0.029089808,-0.05886765,0.0016935946,0.046667106,0.058809154,-0.009417491,-0.003977224,2.5046234e-33,0.007860912,0.063086666,-0.011061708,0.06714813,-0.023823764,-0.034579758,-0.043472238,0.046460256,-0.048888415,0.015582866,-0.04844521,-0.021951757,-0.0046857777,0.025543844,0.024970623,-0.059340812,0.0035175595,0.075102486,0.09876748,-0.024630148,-0.011923412,0.025313914,0.001863866,-0.0771301,0.032297816,-0.01149882,-0.055291608,-0.00825628,0.03111836,0.027578942,0.0073988703,-0.0031905163,-0.050886627,-0.022330735,0.017414555,0.043301996,0.00054770237,-0.06863156,-0.05329137,0.09656327,0.037439395,-0.013041593,-0.033753075,-0.05249787,0.030293813,-0.024764862,-0.063799724,0.006051395,0.040569536,-0.022184558,0.04713574,-0.048214767,0.06198185,0.012430574,0.013187543,0.030233612,-0.049471565,0.022783682,-0.03471256,0.059894435,0.015785038,0.11373061,-0.061256032,0.04039204,-0.045989323,-0.0019350188,-0.051504247,-0.10328679,-0.09572224,0.06687955,0.001024553,0.02758194,0.06224342,-0.0100037325,0.070794016,-0.018899478,-0.097999595,0.103719555,0.08035503,0.011836566,-0.011954118,-0.050615214,-0.023676518,-0.016111504,-0.01548813,-0.0041444497,0.020598723,0.05307103,0.06605968,0.027418977,0.06355212,-0.061845057,-0.04793379,0.06941492,-0.017644739,-3.3836245e-33,-0.014930935,-0.12446931,0.07062615,-0.10689774,-0.03694351,0.0681048,0.002369624,0.040830154,0.06252086,-0.018693676,0.11533788,0.027432624,-0.03838342,-0.058447942,0.06618687,0.033962056,-0.038059924,-0.03777665,-0.0850387,-0.040308904,-0.021775244,0.028802756,0.030927144,0.19384502,0.0041228128,0.034397192,0.053489715,0.06383554,0.09427524,0.020799424,0.016888052,-0.017154746,-8.5295425e-05,0.011362798,-0.06114019,-0.00021659269,-0.05573046,0.14173855,0.032335527,0.018130502,0.022738105,0.02410673,-0.00034253305,-0.023282485,0.06753024,0.060923237,-0.020009344,-0.06557491,0.07147905,-0.042753093,0.05283741,-0.017975068,0.0030456188,0.06317512,0.025554584,0.073796265,-0.09012199,0.030644353,0.08160622,-0.12215606,-0.07580074,-0.013014416,0.02214509,-0.019485382,0.03175071,0.0029145586,-0.035063114,-0.034365408,-0.032835864,-0.020989224,0.006747443,-0.010450373,-0.045073844,0.013432946,-0.02598937,-0.022599734,-0.08573226,-0.03622233,-0.020959396,-0.01240883,-0.007868373,-0.011484679,0.062759474,-0.052189168,-0.058811534,0.019537577,0.002227499,0.10217812,0.02939926,-0.036857937,-0.020787278,0.040188696,-0.10551809,-0.002768906,0.045736846,-4.2881638e-08,-0.008182237,-0.023251906,0.065192066,-0.03796176,-0.06635855,0.0044082105,0.061238352,-0.02474487,0.09103163,0.002170574,-0.018525513,0.09602062,0.03438941,-0.061311863,-0.0012059276,0.0014493915,-0.0014234479,0.021848282,0.035270937,-0.108195506,-0.07346996,-0.0010651308,0.051353924,0.0036807065,0.0106059145,-0.042133115,0.059517365,0.047255266,0.07016999,-0.028839553,0.0062630586,0.020152472,0.008086108,0.09805169,0.0030774132,0.04506243,0.048072558,-0.069796175,-0.0062904223,0.09785491,-0.0005459468,-0.09865793,-0.052731268,-0.015541829,0.04702923,0.029970247,0.07883122,0.06453144,-0.0065389243,-0.046660617,0.00470692,-0.038899533,-0.08419205,-0.059908476,-0.048284538,-0.025609953,-0.046347853,-0.07212619,-9.966635e-05,-0.026636537,0.03734896,-0.052429307,0.18541646,0.015711254 +2.3.1.155,A peroxisomal enzyme involved in branched chain fatty acid beta-oxidation in peroxisomes. It differs from EC 2.3.1.176 (propanoyl-CoA C-acyltransferase) in not being active towards 3-oxopristanoyl-CoA.,384,1.0,-0.061481334,-0.056494102,-0.0578582,0.022788504,0.046371516,0.021396935,-0.15284866,0.03709804,0.0600412,-0.058777,0.06571451,-0.05328142,-0.07318549,-0.009766904,0.0017921678,0.06685081,-0.076602705,-0.017451556,0.06545875,-0.000111720576,-0.033179004,0.003343122,-0.009497189,0.041150123,0.048369497,0.037379198,0.03872681,0.009790904,-0.015695684,-0.051583808,0.00014006037,-0.09720086,0.0870814,-0.0024393427,0.024055649,0.036004398,-0.08866658,-0.08578518,-0.057118706,0.026251841,0.025049798,-0.0091298,-0.044061072,0.015780544,0.0437822,-0.06157512,0.022235788,0.0067767114,0.0023790943,-0.01830057,0.0014752374,-0.10796359,-0.07495781,-0.0022183345,-0.022756824,-0.028393105,-0.014338531,-0.02368406,-0.0064500575,0.052018434,0.0035219635,0.022072742,-0.030650528,0.005818753,-0.0065393276,-0.031521536,0.068463944,-0.069283746,0.027212812,-0.0894011,-0.064121775,-0.052118957,0.006093594,-0.022544466,0.0110154655,-0.0016623229,-0.02444427,-0.062497176,0.030449532,-0.056485843,-0.049166586,-0.043025866,-0.06905912,0.019415889,0.027542105,-0.02415908,-0.030902568,-0.01447938,-0.073847234,0.030450601,0.012322934,-0.01045071,0.0036397316,0.0019465934,0.01269953,0.07161501,0.054746583,0.07910322,0.00265917,-0.020347431,0.008004355,0.1389605,-0.08412292,-0.070423655,0.018503714,0.06657723,-0.021455135,0.033468023,0.025395378,0.019469053,0.005056394,-0.007813682,0.05739035,0.02626682,-0.029097792,0.026204588,-0.009818704,-0.047729135,0.039957166,0.11085978,-0.03951189,-0.062616974,-0.0043105553,0.018175354,-0.015507011,0.0050728694,-0.012811463,1.1135433e-33,0.05690118,0.058733895,-0.017407654,0.029571185,-0.0006037685,-0.011710111,-0.14119607,-0.03500033,0.016500557,-0.01557267,-0.020885624,-0.007429971,-0.006373744,0.06582304,0.04479524,-0.037743222,0.033467587,0.014250056,0.08157887,-0.042292677,-0.01103305,0.009340354,-0.011241395,-0.053978432,0.021127766,0.043708444,-0.015127197,0.041046385,-0.0051359893,0.017519977,0.027123906,-0.06187602,-0.050276663,-0.0059453733,0.0481802,0.017337192,-0.0239157,-0.04977758,-0.094910294,0.08613757,-0.006384573,0.0023954753,-0.025252605,-0.025472658,0.0702648,-0.03894677,0.0036897252,0.12167805,0.05900869,0.024262818,0.0077774795,-0.0076444778,0.06466755,-0.031134434,0.014365223,0.0057439483,-0.04871218,0.025656462,0.04492339,0.005659943,0.011800605,0.11247015,-0.040305506,0.040184986,-0.02665615,0.027894672,-0.11840499,0.014844572,-0.03497556,0.041325644,0.02353854,0.031686828,0.05118188,0.02629075,0.02261093,-0.028563017,-0.07789752,0.049538493,0.055229656,-0.07302158,-0.09237597,-0.008785472,0.012175533,-0.03171158,-0.0098958155,0.056295328,0.024436815,0.024894273,0.045983903,0.04533759,0.06455313,-0.026832955,-0.03318967,0.048711874,0.054743398,-2.531146e-33,0.00060653803,-0.110405855,-0.016362682,-0.15048607,0.014802514,0.022911593,-0.009293,0.03145003,0.024489451,-0.039327078,0.04325775,0.023084462,0.008455355,-0.10427197,0.08441265,0.02011958,-0.042958904,0.04669172,-0.02029424,0.00305915,0.0751557,-0.030271897,-0.029445883,0.14355342,-0.007605286,0.022448482,-0.011907827,0.056059808,0.059029203,0.020391045,-0.012671635,0.0400597,0.00701128,-0.014174484,-0.020792333,0.04651387,-0.08172727,0.10372287,0.015479067,0.058970544,0.027069476,0.05710757,-0.047680825,-0.012062133,0.07103713,0.07413242,-0.065196544,-0.103760585,0.060967173,-0.12106273,0.017938321,-0.018637467,0.046947606,0.031699367,0.044978082,0.08096315,-0.09099019,0.035855096,0.11380908,-0.12866956,-0.055043925,-0.09921956,0.035177678,0.013656997,0.0042629004,0.013637805,-0.0008966724,-0.018014599,-0.006001857,0.039473783,0.02102609,0.0055382857,-0.038906857,-0.027042923,-0.01775189,-0.05580247,-0.052310962,-0.07216502,-0.042707972,-0.014478411,-0.0131561905,0.017683396,-0.0017069172,-0.03407685,-0.0545446,-0.03825787,0.0059634503,0.1053013,-0.015974334,-0.0101141855,0.019181663,0.065025955,-0.092538975,0.01222463,0.06883803,-3.4182825e-08,0.033472095,-0.03136164,0.13043697,0.046155058,-0.009520049,0.0041567264,0.062222056,0.013996447,0.013221586,-0.03222826,-0.005059131,0.12776548,0.036351815,-0.055879574,0.006488327,0.007721462,0.0063529937,-0.003831187,0.027236605,0.00012149301,-0.08871218,0.019276042,0.016824627,0.015481996,-0.023572855,-0.017239729,0.025815157,0.04336541,-0.029321587,0.00091099757,0.046762098,0.056118578,0.0053660455,-0.04384878,-0.07904161,-0.010880195,0.11876829,-0.015355762,-0.06584073,0.051507376,0.01740823,-0.11349564,-0.08236516,0.0066199945,0.052864224,-0.030040748,0.033926193,0.06645109,0.0032038745,-0.03728228,0.07957687,-0.035181124,-0.112398244,-0.020970799,-0.032773998,-0.04228279,-0.023974938,-0.025236646,-0.034561533,-0.05340864,0.09979433,-0.030398203,0.18017434,-0.0656768 +2.3.1.156,"Closely related to EC 2.3.1.74, naringenin-chalcone synthase. Also acts on isobutyryl-CoA as substrate to give phlorisobutyrophenone. The products are intermediates in the biosynthesis of the bitter acids in hops (Humulus lupulus) and glucosides in strawberry (Fragaria X ananassa). It is also able to generate naringenin chalcone from 4-coumaroyl-CoA.",384,0.99999994,-0.085414454,-0.023967905,-0.05132035,-0.012649506,0.036802158,0.07083494,-0.04511348,0.0011412351,0.036529955,-0.05671906,0.052679986,-0.10345893,-0.013412914,-0.035609607,-0.04114931,-0.0049622008,-0.048075955,5.3303942e-05,-0.087968364,-0.10911535,0.067373015,0.009649305,0.041360546,0.041394025,0.0014681878,-0.04128265,0.059772413,-0.02596251,0.008030785,-0.11669473,0.06915597,0.015251294,0.066317864,-0.012813579,-0.04690345,0.011123396,0.007867984,-0.06260198,0.10996346,0.032946244,0.072253436,-0.028151073,0.011349715,-0.034921404,0.014973498,-0.065765575,-0.03938017,-0.034314785,0.016261503,0.07914847,-0.006121806,-0.015387045,0.024810577,-0.0013379575,-0.027647527,0.078758255,-0.016419655,0.05365222,0.022806292,0.021279886,0.10580381,-0.027338121,-0.044009745,-0.04854261,-0.047756888,-0.025558455,-0.003377954,-0.037689537,0.120708115,-0.09684537,-0.041983306,-0.0780319,-0.047588628,0.04526706,0.037414577,0.13000727,-0.008694391,0.009395924,-0.026911637,-0.0010584838,-0.018403707,0.034310527,0.012225184,-0.002792587,0.019933157,-0.0027253423,0.0047575957,-0.011763068,-0.010788736,-0.003407601,0.018043403,-0.046199128,0.024271129,-0.0053120703,-0.008031767,0.12298485,-0.0011669669,-0.01506995,-0.01743972,0.0066079814,0.025333716,0.030613894,-0.033568487,-0.07387387,-0.022655725,0.033588354,-0.0012511795,-0.008796,0.021405708,-0.03766477,0.00755799,-0.06648234,0.039623536,-0.06306766,-0.017187601,0.12594639,-0.032731526,-0.029171377,0.020810919,0.0031069424,0.06350776,-0.008375241,0.014117269,0.054070838,-0.018803047,0.033752218,-0.07889718,6.185868e-33,0.07679898,0.03173383,-0.014840627,0.06443759,-0.014254576,-0.009607628,-0.12155997,0.071384646,-0.0019528067,-0.13362071,-0.084032975,-0.021129183,-0.011513837,0.014354059,-0.06496964,-0.029280784,0.009957807,-0.053052492,0.05894696,-0.03755593,-0.040481843,0.0058814203,-0.005921411,0.00090178626,-0.04982244,0.0007084632,-0.002834174,-0.015279594,0.07304344,-0.015732102,0.057753045,-0.04010185,0.028486952,0.027899683,-0.031706132,0.020132054,-0.08640187,-0.04609969,0.020606045,0.11003391,-0.027794085,0.02655385,0.053389102,-0.021692913,0.035164833,-0.064389616,-0.07016549,0.016719721,0.057200782,0.0360104,-0.0060565537,0.027151119,0.12992208,0.048278783,0.02095839,-0.051089928,0.01973248,-0.0593373,0.05527229,0.010082827,-0.014765969,0.09966557,-0.026134543,-0.021132471,-0.0065212483,0.13042161,-0.06282163,0.022606837,0.0035729678,0.03382073,-0.02451195,-0.03361461,0.008476588,0.033898894,0.03693332,-0.031554636,-0.06128458,0.015029172,0.024046402,0.043707397,-0.053108282,0.03461977,-0.053244133,0.057035252,-0.08747349,-0.05765844,-0.03283109,-0.039956093,0.10315642,0.04726546,-0.011593879,-0.010615083,-0.07566059,0.05398852,0.015676066,-4.24025e-33,0.05383495,-0.05339228,-0.037836425,-0.044509865,0.005835261,0.0037636522,0.008882631,-0.047207855,-0.022384247,-0.00024397683,0.06029131,0.008055366,0.07972204,-0.05560101,0.04276399,0.039200198,0.09814742,0.047744483,0.015213423,0.012226048,0.016652191,0.08205529,-0.046311773,0.029076418,0.053788867,0.00604166,0.05118212,-0.0007997002,0.05457984,0.053071383,-0.046729233,-0.033979565,-0.015085936,-0.016042218,-0.022747671,-0.005173767,0.02526036,0.039331708,-0.069300115,-0.057374675,-0.019647153,-0.018397551,-0.0022719968,0.03914711,0.11850315,0.03366227,-0.071584225,-0.030180147,-0.0771256,0.02511097,0.09320384,0.06737113,-0.009175227,0.0030641262,0.04974184,-0.030790297,-0.0132669415,0.0399333,0.071781196,-0.07477644,-0.11113558,-0.039385058,0.011372482,-0.08934651,0.059366196,0.09951913,-0.107907444,0.122647464,0.003705377,-0.021724464,0.09933032,-0.010920913,0.08082031,-0.015437377,-0.047200467,-0.045454565,-0.04295633,-0.025564991,-0.0020066802,-0.001098301,-0.059975576,-0.029070087,0.04840848,-0.045269147,-0.053251907,-0.03549643,-0.0072459467,0.047832653,0.048434395,0.016511202,-0.040619988,-0.019287268,-0.10868859,0.064665444,0.09585179,-4.2279552e-08,0.0008515641,-0.08894511,0.02187373,0.026426272,0.021456374,0.042889044,-0.0065185027,0.021066248,-0.044924848,0.0063952557,-0.014298382,0.08807778,0.04643132,0.026991405,-0.020848587,0.035990186,0.019756176,0.08645824,-0.0045966497,0.011660261,-0.08024981,0.061296243,-0.07914394,0.016414331,-0.03342605,-0.08580309,0.015489997,0.009695101,0.011001294,-0.05761371,0.0561973,-0.0030130898,0.0667883,-0.026652347,-0.034768768,0.019372527,-0.006588504,0.008693669,-0.038861703,-0.02660874,-0.06096631,0.0028606183,-0.03455448,0.00420961,-0.01165762,-0.0749484,0.093132526,0.023573734,-0.0006807888,0.027492572,-0.020088483,-0.026080431,0.06522351,-0.030154942,-0.07042489,-0.08377307,0.0009355771,-0.092209816,0.014257214,-0.019804163,-0.0022404487,-0.034207184,0.22669967,0.010779472 +2.3.1.157,"The enzyme from several bacteria (e.g., Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase.",384,0.99999994,-0.048059706,-0.08181386,-0.029777344,-0.01080918,0.0026411,0.029679108,-0.010075061,0.046733882,-0.016546547,0.017434014,-0.032182302,-0.07795713,-0.05790973,0.08110346,-0.048025608,0.03804068,-0.05437685,-0.09106981,0.05602573,-0.093021214,0.038595263,0.019155286,-0.07369524,-0.010955498,0.024142474,0.0144808795,0.08437992,-0.028011076,-0.059419837,-0.09985414,-0.022328777,-0.052337624,0.07334619,-0.02468977,0.10401087,0.07236982,-0.028919088,-0.08326227,0.04221999,0.02600492,0.057770498,0.015272843,-0.008644235,-0.07183794,-0.012649666,0.008168101,0.06536478,-0.008126116,0.07053508,0.031942584,-0.022700422,-0.018493328,0.007809137,0.06247778,0.07081095,-0.0050272853,-0.06726569,-0.06547291,-0.028117621,0.0448545,0.014497352,0.0023987808,0.07451943,-0.054034334,0.012698345,-0.084778,0.076224886,-0.10343899,0.013472912,0.009935667,-0.086079426,-0.046164405,-0.018808596,0.0036970198,0.074307814,-0.015047786,-0.0029138434,-0.07186001,0.07160326,-0.09667372,0.0064258724,-0.05507247,-0.003881014,0.09256163,-0.029271247,-0.04085388,0.03206098,-0.029561004,0.05452928,-0.009156997,-0.03819988,-0.06763338,0.003760513,-0.05906246,-0.04487016,-0.020087881,-0.018770825,0.06629574,-0.0013326231,-0.013718048,-0.0035631275,0.086717114,0.04985816,-0.08760078,-0.03956,-0.01784005,0.015243892,0.10319677,0.08043416,-0.030596102,-0.02511662,0.019792309,0.09448638,-0.022708436,-0.04241767,0.056106865,-0.007049586,-0.12421378,-0.014509379,-0.017235091,0.053822413,-0.035247732,0.08065067,0.09138407,-0.04645872,0.06067862,-0.089416824,2.048437e-33,0.08417391,-0.045079455,0.03184777,0.00034516215,-0.04811606,-0.008206607,-0.07003034,0.015882127,-0.023480818,-0.08942813,-0.018845737,-0.022816347,0.12020078,0.09599143,0.010191801,0.020120302,-0.00084923435,0.0016730195,0.03217999,0.01510121,-0.0022532505,0.02700541,-0.045049407,0.029045,0.07136173,0.019195631,-0.045870237,0.069863595,0.040285036,-0.0084149195,0.033018988,-0.029433161,-0.1293956,0.044991206,0.051884074,-0.043911267,-0.019655988,0.0050763143,-0.01554649,0.0025819615,0.04230681,0.052800976,0.046453707,-0.073855154,0.03390704,-0.068003654,-0.08994234,0.080895066,0.06075105,0.061488464,0.036219835,-0.053676836,0.14197433,-0.032346666,0.057461783,0.0798672,-0.036829192,0.0044579515,0.08138264,0.045835096,-1.3842138e-05,0.078362525,-0.09840158,0.041139577,-0.03504297,0.096038535,-0.017355934,-0.028490115,0.04261111,0.062001828,-0.05191517,0.06166796,0.011904682,0.0013590533,-0.019803409,-0.08174057,-0.0689948,-0.018754253,0.024846705,0.06793441,0.010200793,-0.072660126,0.057139285,-0.018230146,-0.0698818,-0.011940524,0.023096165,-0.05889468,-0.004949741,0.095877014,-0.036735687,-0.0437837,-0.06882855,0.049219,0.044887524,-3.9721137e-33,0.09256085,-0.09733536,-0.051498972,-0.06316215,-0.08653076,0.0721322,0.061279215,-0.022080515,-0.044538535,-0.00017591882,0.07848786,0.015605726,0.04256091,-0.041033,0.041967012,-0.0027915833,-0.035292935,0.07725382,0.047621112,0.02135389,-0.046496775,0.06516344,0.015729103,0.012745347,0.074291185,-0.007256868,-0.029780662,0.04257488,0.007782654,-0.015235432,-0.07809498,0.023894675,-0.047731884,-0.021144532,-0.05367681,-0.025688615,0.042422127,-0.00088463374,0.018908108,-0.05873845,-0.009327786,0.07945183,-0.003791093,0.04954849,0.040976427,0.09096055,-0.041026335,0.023683365,-0.078719355,-0.059124034,-0.049502112,-0.03139548,0.0023596438,-0.039092656,-0.054117195,0.049294647,-0.021340191,0.044625822,0.09246993,-0.045263987,-0.0026428225,-0.07104164,0.019547405,-0.014361054,0.023203747,0.031045116,-0.07007513,-0.012686369,0.023061397,-0.03522269,0.012048121,-0.033685233,0.04692565,0.03289148,0.0043687397,-0.015351758,-0.052794993,0.02157544,0.057999276,-0.039113116,0.06836502,0.0008442369,-0.02712207,-0.024887305,-0.020328186,-0.029089501,0.02194421,0.095069386,-0.028189965,-0.012201393,-0.057271842,-0.03785233,-0.07157193,0.026979376,0.06041508,-4.2382077e-08,0.069100805,-0.010636617,0.0013273781,-0.06211412,0.022315655,0.039687194,-0.021431139,0.021686016,0.049612783,-0.00039584725,-0.00088427216,0.07980855,0.020699775,-0.003995061,-0.0033397623,-0.034300864,-0.020774363,0.0076257084,-0.01730062,0.060691286,-0.011061492,-0.04120971,-0.113305874,0.070833035,-0.020894818,-0.07274207,0.04459037,-0.012604117,-0.040720113,-0.06934805,-0.09139671,0.028948821,0.030919826,-0.059672363,-0.013488205,-0.0124003105,-0.04001377,-0.008456495,-0.032730896,0.07932697,0.07639647,-0.0032800229,-0.081060305,-0.024069568,0.016067116,0.030327644,0.023831032,-0.01645831,-0.025499681,-0.045032162,0.007996846,-0.04481394,0.030120583,-0.040762145,-0.081422895,-0.026946384,-0.023356382,-0.09586172,0.010691116,-0.01690687,0.041711405,0.053616997,0.09799698,-0.013285329 +2.3.1.158,"This enzyme differs from EC 2.3.1.20, diacylglycerol O-acyltransferase, by synthesising triacylglycerol using an acyl-CoA-independent mechanism. The specificity of the enzyme for the acyl group in the phospholipid varies with species, e.g., the enzyme from castor bean (Ricinus communis) preferentially incorporates vernoloyl (12,13-epoxyoctadec-9-enoyl) groups into triacylglycerol, whereas that from the hawk's beard (Crepis palaestina) incorporates both ricinoleoyl (12-hydroxyoctadec-9-enoyl) and vernoloyl groups. The enzyme from the yeast Saccharomyces cerevisiae specifically transfers acyl groups from the sn-2 position of the phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid.",384,1.0,-0.08331981,-0.090925746,-0.12122667,-0.01500303,0.014116534,0.0050500226,-0.10566911,0.019182209,0.07523402,-0.02837436,0.08655457,-0.09765949,-0.1011404,-0.0035635734,-0.021333938,-0.0268918,-0.033842664,0.018568799,0.011916274,-0.097393885,0.089466855,0.017396249,0.041366566,0.09021189,0.010078819,-0.0658581,-0.012101384,0.016229961,-0.047478955,-0.1038073,0.036108654,-0.06357588,0.024398226,-0.08508859,0.03911047,0.016834171,0.039286364,0.035388194,0.062181838,0.010582646,0.0038818882,-0.04698266,-0.03551087,0.063825205,-0.018732658,-0.05055675,-0.036517497,0.06772209,0.025237102,-0.0062311017,-0.04073361,-0.07166275,-0.05774365,0.012629794,-0.011501675,0.04836841,-0.05025847,-0.01184667,-0.015470096,0.030071655,-0.012112272,-0.041546565,0.007528901,0.043031756,-0.12355146,-0.041680753,0.0022176644,-0.085388586,0.0637537,0.016546618,-0.012192077,-0.12242926,-0.016336536,0.033587042,-0.011527438,0.03713888,0.06920824,0.010244221,0.024028568,-0.058416374,0.040485088,-0.0063437712,0.02815854,-0.0030951053,0.0042180386,-0.043162465,0.009263657,-0.002830806,-0.010274551,0.022755045,0.100157894,0.0090009,0.034649808,-0.05120869,0.035721168,0.026078887,0.007015905,0.0648987,0.016615143,-0.029293569,0.024983415,-0.013876736,0.007157808,-0.081550255,-0.0150923375,0.04650309,-0.036687817,0.033271797,0.056776065,-0.013091216,0.005553244,0.007943833,0.033304237,0.051929746,-0.025615377,0.025597485,-0.057664905,-0.031207848,0.035958152,0.02644319,0.0052259797,-0.03609406,0.031293355,0.029461589,0.0060728304,0.029948771,-0.08108464,5.9902318e-33,0.052253373,0.07238817,-0.07893973,0.0061325114,-0.013133865,-0.042488392,-0.08663843,0.09764232,-0.11993535,-0.016326174,-0.05722853,-0.03215744,0.0011818659,0.05610195,-0.008237343,0.03056141,-0.028099326,0.014512061,0.08412042,-0.036984365,-0.031556845,0.051932786,-0.04467874,-0.027118031,0.038331624,0.08977194,-0.0012995375,-0.02040326,0.008262852,0.019729417,0.015927428,-0.12030203,0.00869951,0.038270775,0.05880512,0.040034186,0.047315955,-0.021699326,-0.02846649,0.0780587,0.01604009,0.012880112,-0.0014816799,-0.020213054,0.055211887,-0.052546334,-0.06857718,0.10810642,0.03886446,0.05971551,0.023025658,0.006447012,0.16268083,0.1022998,0.021532642,0.029670602,-0.025620243,0.038006052,0.038195144,-0.022524303,0.03535963,0.13541,0.00014625092,-0.038342956,0.041596595,0.025085932,-0.07600657,-0.06214907,-0.04331299,0.05853875,0.042728767,0.03080089,-0.00875487,0.06163165,0.057797275,-0.024814336,-0.008805743,0.058888797,-0.038069583,0.0785904,-0.02884191,0.037131123,0.048448827,-0.039292514,-0.075622976,0.0046279626,0.0040452383,0.011110532,-0.0009921951,0.0069508743,-0.03380776,-0.057515454,-0.009719589,0.107981466,0.016894212,-5.3014193e-33,0.06195974,-0.075598545,0.08530604,-0.06661231,-0.10325465,0.06878597,0.046852876,-0.013150949,0.0736757,-0.06874557,0.07134775,-0.026048325,0.037100006,-0.07293541,0.034696516,0.01271527,-0.08180448,0.052599367,-0.04098108,-0.032340676,-0.021598194,0.080019265,-0.019821811,0.10799451,0.023659492,0.0098991,-0.0006340404,0.049418733,-0.027581481,0.056736197,0.003404871,-0.065526254,-0.014363193,-0.024070561,-0.07038266,0.067936,-0.11156449,0.042901285,-0.017138144,0.08206692,-0.00771928,0.085135765,0.029118769,-0.045548823,-0.0015952734,0.074162506,-0.02222712,0.026945468,-0.0338322,-0.075938076,0.0016859564,-0.0041479273,-0.0058884895,0.08011685,0.03823192,0.07989855,0.012815227,0.04770542,-0.07610108,-0.054747447,-0.03803946,-0.088185154,0.021375258,-0.01514042,0.07321971,0.06744958,-0.060005512,-0.048799034,0.039363027,0.022926908,0.0025137728,-0.01048208,-0.057374965,0.040097505,0.0060780644,0.060366146,-0.025344584,-0.055731416,-0.02800938,-0.044067595,0.018528113,-0.03994886,0.033032905,-0.021064216,-0.039876793,0.004409262,0.00048747132,0.0699168,0.061557446,0.034232534,-0.00046621903,-0.015408852,-0.059084248,0.019137524,0.108005695,-4.6685905e-08,0.05785408,-0.022078859,0.06755979,-0.040196795,0.004969777,0.028989896,0.056629494,-0.029502982,-0.013535631,-0.032658022,-0.123657234,0.06739074,0.032219835,-0.003808978,0.019406594,0.014594814,0.019212205,0.09659855,0.03756847,-0.054988712,0.00020314843,-0.029814288,-0.01978986,-0.0059684464,-0.037573,-0.06590407,0.033718463,-0.00033585573,-0.020708775,0.024325995,-0.02287318,-0.012682022,-0.057293028,-0.0045957114,0.025528088,0.04767107,-0.118823215,-0.036268473,-0.057348486,0.085945815,0.018918257,-0.020601736,-0.052630987,0.03563229,-0.031888366,-0.0851011,0.036575504,0.020129824,-0.020399317,0.0006100696,0.020846482,0.0036695662,-0.027793074,-0.0911763,-0.10324379,-0.06504392,-0.011174802,-0.05990537,-0.007831614,-0.003379073,0.025588414,0.0024199565,0.13696043,-0.080330916 +2.3.1.159,"Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)",384,1.0,-0.15418704,-0.059688944,-0.07956719,0.00052310555,0.08419208,0.016685799,-0.0662634,-0.00373398,0.060170084,-0.033461384,0.021105003,-0.09501629,-0.011008006,-0.081675015,-0.07675189,0.0495586,-0.06983575,0.032178577,-0.007661751,-0.018401735,0.005756505,-0.012922847,0.034611344,0.049644593,0.021412162,-0.01274797,0.06874399,0.004799102,-0.008125035,-0.08681473,0.004531087,0.03230132,-0.026210692,0.019265551,-0.014478009,0.08911781,-0.015009647,-0.052099425,0.039017797,0.023803724,0.05264273,-0.0055490825,-0.008100197,-0.034926053,-0.00068533496,0.031716328,-0.089523174,-0.043418653,-0.017757779,-0.0075521623,-0.027814532,-0.032099325,-0.039222594,0.039942473,-0.0006212245,0.07914577,-0.01937265,0.06394309,0.04945664,0.0068268157,0.06349283,0.008261965,-0.010954346,-0.04060455,-0.05859558,0.03270839,-0.08715238,0.029210478,0.09301432,-0.07983819,-0.09822405,-0.022429254,-0.015326378,0.07141649,0.021029174,0.052392434,-0.030823633,0.09147953,-0.017886361,-0.048908997,0.0040073334,0.029851187,0.04701282,0.015186272,0.06479959,0.054062735,0.029618999,0.034548994,0.061836902,-0.023028528,-0.043502882,0.036928505,-0.02921013,-0.005952761,-0.072727524,0.07114135,0.033758357,-0.0064980066,0.019361412,-0.027956037,0.012373407,0.002332289,-0.026376368,-0.060429268,-0.01096364,0.022557931,-0.018345859,0.045520186,0.058727816,-0.07800077,-0.048467446,0.041745663,0.006823726,-0.03552007,-0.028944585,0.023256904,-0.0006159923,-0.042997837,0.041102067,-0.0043692198,0.028554603,0.02027358,-0.05254533,0.033013858,-0.05446882,-0.042450912,-0.17704105,1.5070308e-33,0.08888226,0.09137678,0.026815688,0.04228769,0.0040785586,-0.025414651,-0.052561216,0.051713046,-0.0964485,-0.09292943,-0.079965405,-0.1021004,-0.04197453,-0.006649709,-0.029979799,0.023163833,-0.018921118,0.00018798544,-0.01652907,-0.14378752,-0.055023782,0.07122474,-0.06576341,0.02280083,0.018489337,0.029725373,0.037734576,-0.07848071,0.022877162,-0.03284469,0.006593129,-0.03358155,0.001075823,0.07489992,-0.04039706,0.023951523,-0.0072875707,-0.12669064,-0.028664349,0.064338,-0.017563133,0.008841709,0.044533793,-0.05104248,0.06683896,0.006199998,-0.0006867034,-0.0014208027,0.048004806,0.03406328,-0.045309115,0.034294233,0.0789351,0.039046064,-0.057723198,-0.02312259,-0.021011308,0.02817802,0.048216365,0.045184202,0.03145093,0.08023386,-0.06184909,-0.018211922,-0.007927173,0.10678876,-0.06692962,0.020039046,0.032159798,0.08806508,-0.021442313,-0.082473226,-0.00042653043,0.055661626,0.08282236,-0.015751602,-0.09842738,-0.034302056,0.02410149,0.031211773,-0.06224767,-0.02908192,-0.045732904,-0.02539878,-0.081190154,-0.096278496,-0.00907932,-0.048731435,-0.035748348,0.08839188,0.040128358,-0.024991138,-0.053950407,0.06293776,0.012991985,-2.4989856e-33,0.082950264,-0.04916593,0.00106077,-0.06867837,-0.058349337,-0.022220481,-0.026792765,-0.08224992,0.05808802,-0.008630175,0.0722278,-0.030061541,0.04930955,-0.03366812,-0.027608478,0.037568774,0.070606686,0.041404642,0.0295673,-0.015777778,-0.004329021,0.07928598,-0.014496051,0.037349988,-0.019730639,0.021862423,0.08402408,0.06237216,0.030661207,0.056440663,-0.06084541,-0.029183265,0.009947949,0.0053890087,-0.02462829,0.007785468,-0.07695456,-0.03576658,-0.023951601,-0.008959931,-0.037897766,-0.06462172,0.061767474,0.107254304,0.049827263,0.01815725,-0.078746766,0.017376704,-0.008550759,-0.02012566,0.059349187,0.031315383,0.001510588,-0.030828431,0.0023984201,0.025739694,-0.029419005,0.012927878,-0.026221527,-0.05029392,0.030309979,0.00067650405,-0.019444065,0.031868346,0.054821253,0.13874568,-0.08916201,0.084475875,0.047542464,-0.02952701,0.1462993,0.00934199,0.006714969,0.05560346,-0.042485587,-0.08674404,-0.031012023,0.006717411,-0.03124165,-0.0042874985,-0.00023548552,-0.028998723,0.025394807,-0.036024194,-0.07558878,0.010404704,0.0029988803,0.07314579,0.033850726,0.030661603,0.015982743,0.03442427,-0.06680418,0.10064968,0.08521004,-3.4065582e-08,-0.02273313,-0.035556965,-0.0062110852,-0.032806735,-0.029889992,0.007155353,0.015885599,0.020427125,-0.06736332,0.03419486,-0.05527599,0.05093985,0.05489799,0.047575973,0.05890723,-0.014080401,-0.03232638,0.059813485,-0.0074717733,0.009477451,-0.0375475,0.054130238,-0.054341894,0.02360597,0.007489442,-0.073460214,0.019411579,0.037805643,0.024006218,-0.033688415,0.06337695,0.021099012,0.008969246,-0.022051562,0.018634064,0.117743455,-0.00434026,-0.06058378,0.024496224,-0.022922808,-0.019329816,-0.0012036044,-0.011928007,0.034304775,-0.032562412,-0.009180698,0.08409238,-0.040044323,0.026543483,-0.01739869,0.059400715,-0.030588722,0.040173292,-0.069691926,-0.10682499,-0.0034576147,-0.045098595,-0.054314766,0.020404117,-0.07762183,-0.004489438,-0.0358964,0.2003322,0.040705595 +2.3.1.160,"The reaction proceeds in two stages. The indole nitrogen of 16-epivellosimine interacts with its aldehyde group giving an hydroxy-substituted new ring. This alcohol is then acetylated. Also acts on gardneral (11-methoxy-16-epivellosimine). Generates the ajmalan skeleton, which forms part of the route to ajmaline.",384,1.0,-0.02080451,-0.00031706918,-0.06700429,-0.03035341,0.02183806,0.01477992,-0.028645331,-0.04181092,0.031386085,-0.011752869,0.06464426,-0.0059157046,-0.02123215,-9.04853e-05,-0.055749808,0.052202903,-0.029074574,0.028092202,-0.034122914,0.008585203,0.056535427,-0.03759069,0.07085336,-0.055679675,0.035944138,0.074361205,0.043845147,-0.015923362,-0.0077477535,-0.09894469,0.099484384,0.034009624,0.026601916,-0.04567782,-0.025580246,0.00569839,-0.042314406,0.053537067,0.06887378,0.013159652,-0.023281796,0.021926334,-0.02291258,-0.0087617235,-0.0052693915,-0.086405985,0.0051418296,0.010962517,0.027011804,-0.019595154,0.03836249,-0.045652684,0.020821994,0.005936887,0.040205438,-0.033191342,-0.09583588,0.0064817043,-0.013063127,0.024675116,0.08013251,0.040333793,-0.0594254,0.003422731,-0.016631633,-0.08722199,0.050406866,-0.06877151,0.010968476,-0.026302291,-0.011795,-0.022914277,0.025474103,-0.035449594,0.019307211,0.034770735,-0.041370034,-0.00759728,0.02399027,-0.015100896,-0.05337615,0.033269465,0.02172036,0.041811064,-0.009271384,0.037846938,0.03945604,0.017626857,-0.010705449,0.06901043,0.0018628938,-0.021168876,-0.07462071,-0.026100976,-0.005929962,0.016693683,0.076042846,-0.012195783,0.05780565,0.06661289,0.025762852,0.060240515,-0.026045002,-0.08361556,-0.101883315,-0.039260503,0.0139864655,0.08812527,-0.0017267641,0.020281043,-0.02295815,-0.07531107,0.062199015,0.043796446,-0.03977256,0.0904019,-0.042748176,-0.016350895,-0.020415915,-0.059579626,-0.010150877,0.04314327,-0.030325968,0.107555985,-0.04531816,0.04783951,-0.07120526,1.8933886e-33,0.06446582,0.04443061,-0.03612042,-0.017573977,0.0038731543,-0.038557217,-0.06577411,-0.040211808,0.0101609435,-0.07565832,-0.071248025,-0.047553353,0.07878616,0.012123306,-0.036785353,-0.059343163,-0.07301609,-0.0052403025,0.046963952,-0.04194186,-0.079668105,0.05313635,-0.07093607,0.07603193,-0.059917953,0.058206752,0.032602437,0.015554016,0.013433645,0.0027532629,0.008052044,0.031642657,-0.107010305,0.05275648,-0.020887379,0.07895816,0.06084823,-0.036032677,-0.027143896,0.008862918,0.058998413,0.068641536,0.00765234,0.07219791,0.045896914,-0.049728308,-0.090015315,0.14981815,0.09827329,0.029543243,0.0151983285,0.0213674,0.11747822,-0.03513532,-0.06243606,0.108618595,-0.044344835,-0.04400378,0.044117533,-0.019897718,-0.011021536,-0.0023184402,-0.0069960486,-0.0032454291,-0.03206917,0.060882613,-0.0654544,-0.13033515,-0.031133892,-0.013027528,-0.050949346,0.05965083,0.048057336,0.06875793,0.007817446,0.03392768,-0.029816063,-0.027268525,0.016024351,0.04945572,-0.017674481,0.037145928,0.0117018735,-0.03670672,0.06947158,-0.057244636,-0.055601567,-0.0425664,0.026729872,0.13387325,0.05543574,-0.05976535,-0.09397888,0.040223446,0.104183204,-2.541269e-33,0.10183431,-0.08473237,-0.0012035391,-0.009909265,-0.045669716,0.010365021,-0.06326802,0.03632513,0.011461192,-0.044079226,0.029821446,-0.06448186,0.05333168,0.016920902,0.043927573,-0.08968762,0.061447423,0.13324325,0.04123602,0.025192909,-0.008243764,0.083945826,-0.05426836,-0.029819038,0.06609463,-0.01769725,-0.011271091,0.031905,-0.07626156,0.046734143,0.07065908,-0.08486259,-0.03695223,0.017553916,0.010824979,0.10105418,-0.031546,-0.04717998,-0.04103975,0.0030384513,-0.036274407,-0.009096523,0.014915747,0.051349334,0.09101348,-0.0029857585,-0.032116696,0.057265382,-0.036215026,-0.06551701,0.01288451,0.009605232,-0.0074441335,-0.06835136,0.052406736,0.06448248,0.019134663,-0.028059594,0.004861472,-0.057249077,-0.0027215004,-0.045259606,0.045704763,-0.05269515,0.004617969,0.027099645,0.006157006,0.05329099,0.059767384,-0.039790343,0.05848737,-0.027728485,0.011022063,0.09804348,0.10131307,-0.10567352,-0.042278595,-0.041791026,-0.017343042,-0.08610388,-0.0090245595,0.040402364,0.036519263,-0.08781533,0.04137596,0.06675531,0.038375076,0.0856472,-0.043242,0.013525366,0.055265363,-0.013504033,-0.039953254,0.02780639,0.07936192,-3.7857554e-08,0.004873397,-0.004788899,0.03473842,-0.022752438,-0.032091405,0.061420344,0.053520974,0.007464217,-0.0038781108,-0.15983216,0.027361218,0.10572548,0.027624454,0.030292135,-0.000938284,-0.0216953,0.0021125765,0.05030604,-0.07344754,-0.092241414,-0.085002914,-0.004285964,0.02822716,-0.0027458149,-0.015990833,-0.058391728,0.037077542,0.053325217,-0.019219628,-0.09915236,0.007318398,0.021144802,-0.04793584,-0.07264122,-0.09051422,0.038549677,0.0101334555,0.02813723,0.0783105,-0.03244176,-0.04238966,-0.08015942,-0.08429659,-0.013360369,0.037167788,0.012036061,-0.028318428,0.0035236725,-0.067624435,-0.051498964,0.009724928,0.00427417,0.062194563,-0.04639089,-0.054270227,-0.038218044,-0.022149902,-0.013664018,0.043261234,-0.02881006,-0.021151893,0.030524507,0.07529152,-0.04364265 +2.3.1.161,"This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase. The PKS catalyses many of the chain building reactions of EC 2.3.1.85, fatty-acid synthase system, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.",384,1.0,-0.04497578,0.01856078,-0.116149515,-0.0515307,0.10872847,-0.016915787,-0.10134059,0.057575896,0.051237173,-0.039273623,0.034163862,-0.103758,-0.06442634,-0.065199606,-0.06218647,0.03107518,-0.081774,0.06892267,-0.012019397,-0.041091617,0.042580552,-0.016252672,-0.015412366,0.050149884,-0.02731118,-0.014506934,0.0806684,0.02737788,-0.07615548,-0.1310401,-0.0052352767,-0.027869923,0.091868564,-0.08531293,0.019950721,0.15117687,-0.030098507,-0.058404494,0.029146746,0.021625955,0.034045182,-0.06608014,-0.026228283,-0.036983088,-0.04460615,-0.011999347,-0.068865694,0.03852312,0.0033932074,-0.11778597,-0.030018974,-0.029629149,-0.019824255,0.024841787,0.049236722,0.02216421,-0.0461314,0.03176957,-0.02985537,-0.015425035,0.049900897,0.008711697,-0.018680647,0.010137215,-0.024857443,-0.0025561436,0.0390469,-0.08544722,-0.0088234,-0.013507469,-0.131011,-0.031414997,0.009546162,0.03748863,0.054581378,0.09338198,0.017185276,0.001415265,-0.017386844,-0.04911448,0.06699467,0.01874358,-0.030580945,-0.007589426,0.03007172,-0.050291568,-0.041269045,0.020796414,0.020402366,0.039249264,0.058264866,-0.029055797,0.024301356,0.034435708,-0.05028808,0.091904566,-0.0064724856,0.06278419,0.055468034,-0.029969122,-0.027970972,0.048817415,0.023394706,-0.097477466,-0.04277302,-0.021812528,0.00956903,0.10900571,0.043848023,-0.042452335,-0.012006419,-0.06521665,0.027533015,0.009494619,-0.0007418627,0.068684556,0.053779036,-0.07553514,-0.014437826,-0.024386363,0.0460579,-0.029156126,0.026070856,-0.026489954,-0.042483415,-0.040320493,-0.10584021,3.3106535e-33,0.0706783,0.029258028,-0.01790696,-0.016153494,0.050482254,-0.010953175,-0.04544002,-0.014103722,-0.023373496,-0.07237479,-0.031550273,-0.047300357,-0.032118317,0.0764488,-0.02713408,-0.038029768,0.03260837,0.04730593,0.0023296336,0.05479981,0.04284483,-0.010202803,-0.08941873,-0.000711146,0.06921617,0.102646865,0.013536558,-0.048939772,0.0057137827,-0.013075772,-0.011752944,-0.0428169,-0.07545705,0.12262557,0.019411007,-0.021684078,0.01456284,-0.008975887,0.035546817,-0.006152318,-0.014765182,0.026832486,-0.0030323914,-0.016871436,0.021199878,0.04384645,-0.04310288,0.09260352,0.0658345,0.04232527,0.07132193,0.03344316,0.08900757,0.004054677,0.013879564,-0.0047267857,-0.07965364,-0.010277765,0.004930829,0.044710636,-0.019249674,0.114756264,-0.035322636,0.07083171,-0.022202643,-0.008461084,-0.061629236,-0.08466289,0.02349345,0.044808496,-0.05942113,0.0464802,0.071664,0.026275722,-4.4503136e-05,-0.0590957,-0.08372586,-0.04429522,-0.04609017,0.07137787,0.0046440666,0.034203798,-0.033253066,-0.05758751,-0.047578827,-0.0157474,-0.057453755,0.006092918,-0.01522487,0.03433799,-0.027975187,-0.05612687,-0.016614225,0.047335103,0.06197174,-4.11717e-33,0.10772417,-0.05472459,0.04743882,-0.06600009,-0.042875994,0.10835926,0.041003954,0.0048809694,0.036799166,0.024141593,0.076645166,-0.005371992,0.03829473,0.0010242473,0.014447471,0.016481604,-0.020280955,0.04600574,0.0043733823,-0.0658233,0.010471467,0.09314206,-0.011584916,0.12401461,0.07631723,0.040164754,-0.05944139,0.08577965,-0.024029728,0.02786001,-0.036486693,-0.004087024,-0.0063358853,0.015268071,-0.060840186,0.04793133,-0.09621639,0.010640977,-0.019502604,0.057112377,0.025004465,-0.021750402,-0.019202113,0.016514821,0.011788437,0.068893,-0.02582277,0.03456591,0.07573944,-0.07734752,0.019084888,0.06883752,-0.007591236,0.044043,0.03199864,0.030772576,0.0068715345,0.019992726,-0.045161095,-0.04805704,-0.08879741,-0.09505352,0.02467388,0.026882049,0.0075471695,0.020819748,0.010388746,-0.010588822,0.05421885,0.013782829,0.117067665,-0.0046387576,0.0026054627,0.09427611,0.019102573,-0.060909223,-0.0786953,-0.0490966,-0.029999401,-0.024877047,8.9486246e-05,-0.0585946,0.050902024,-0.05574699,-0.04081613,-0.10203001,0.035279337,0.024416232,-0.10003386,0.014062448,0.015123914,0.023434125,-0.059961136,0.1489666,0.053542554,-3.73777e-08,0.0636574,-0.044697322,-0.0069922856,-0.05638824,-0.0032100398,-0.0011915186,0.03776115,0.07001561,0.014308188,-0.042964637,-0.0409814,0.054720085,0.051619634,0.06356231,0.0515945,0.0032784208,0.0029836332,0.040990215,-0.009563329,-0.052846674,0.0056021605,-0.026083725,-0.12471935,0.025204515,0.028603842,-0.037153516,0.025706034,0.038747765,0.028575256,0.058405273,0.017815517,0.018528013,0.0059617353,0.0030520675,0.0103655895,0.057493404,-0.11657396,-0.051397927,-0.016130624,0.039453097,-0.0023511657,-0.024087733,-0.05821342,0.019520646,-0.062077533,-0.03292922,-0.058895737,-0.019230962,-0.0013657701,-0.016548581,0.048026685,0.017189225,0.02178176,-0.043645028,-0.07572714,0.057494003,0.00507812,-0.01661175,-0.010016357,-0.051854935,0.012902033,-0.048705082,0.16156688,0.015983352 +2.3.1.162,"This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.",384,1.0,0.0030254587,-0.020603579,-0.07314803,-0.019919323,-0.03526124,-0.03616391,0.054943208,0.057937916,0.09146842,0.02478805,0.0043552797,0.041926645,-0.016247671,-0.03404727,-0.032103095,0.06427387,-0.05924402,0.03937005,-0.0070699225,0.007846984,0.10500124,0.006583157,0.041441824,0.06030237,-0.02280686,-0.017330248,-0.027730623,0.033325072,-0.03145844,-0.06003844,0.053351566,0.00502377,-0.02321513,-0.04360345,0.02281568,0.019284511,-0.06365282,0.01497404,0.010601383,0.062677756,0.05223623,-0.064336,-0.055638775,-0.017443143,-0.0418857,-0.12014473,-0.09921159,-0.031251963,0.15091267,0.09801036,-0.017013155,-0.030443015,-0.060100153,0.03720024,0.045376997,-0.024030678,-0.023430696,-0.015569126,-0.01808574,-0.009928815,0.0033194022,0.020333791,-0.018103035,0.026075529,0.0010998929,-0.012000368,-0.03451294,-0.059744984,-0.0015368699,-0.033138707,-0.09998128,-0.064013146,0.012308214,0.008979167,-0.048053205,-0.018990746,0.06448839,0.05800301,0.05091887,-0.07353456,0.115630485,0.05752449,0.038381033,0.0801972,0.025940485,0.057883285,0.042259697,-0.027545618,0.13123187,0.026892738,0.017197063,0.09458129,-0.03322515,-0.0013498676,-0.03099935,-0.03134002,0.048789356,0.007145977,-0.037026305,0.046436027,0.059863176,-0.03225226,-0.031958736,-0.12555712,-0.056353234,0.0048477673,-0.080443,-0.013648102,-0.033890072,-0.032044314,-0.0008765075,0.009789203,-0.034514043,0.035397377,-0.016257307,0.12845697,-0.002957533,-0.10563133,-0.0144117065,-0.03881043,-0.037765652,-0.08871154,0.0038017086,0.0039648344,0.0056960285,-0.019048395,0.02988115,5.078101e-35,0.022522015,0.021027884,0.030783238,-0.0020701056,0.019444183,0.010310661,-0.021478204,0.014711655,-0.15970227,-0.094307065,-0.054926842,-0.051060796,-0.04791433,0.059949644,0.019690441,-0.02987013,0.024965692,0.0429478,0.043010566,-0.01997368,0.01752667,0.07248879,-0.047979463,-0.034901686,-0.045621052,0.10470907,-0.046234723,0.015674323,0.059625104,-0.010855255,-0.017054513,-0.0376545,0.01573111,0.02391085,-0.017332917,0.048288554,-0.03560731,-0.030826798,-0.03288587,0.09405634,0.0057057175,-0.013931341,0.04340898,-0.00903916,-0.014762708,-0.01701662,0.00460864,0.0062933457,0.04495991,0.031874754,0.033855636,0.034782764,0.044087004,0.0044303676,-0.06877349,0.06045483,-0.07237777,0.00051076873,-0.009120314,0.016114447,-0.015421211,-0.016015202,-0.04094048,0.0736088,-0.025661895,0.02956896,-0.028237166,-0.03246299,0.06584912,0.10625145,-0.09170756,0.0044877287,0.09239505,0.02310821,0.08853939,0.024361406,-0.0027416518,0.040470313,-0.0339667,0.036162753,-0.0837167,-0.03957098,-0.040758554,0.038943447,-0.088251114,-0.011325262,0.0019665393,0.00558777,-0.042234953,0.0333801,0.0065477877,-0.0762206,-0.06937125,0.037394136,-0.010519878,-3.114764e-33,0.0566176,-0.08664193,0.09581734,-0.034929737,-0.04553434,0.11615143,-0.0041021677,-0.06772906,0.030201163,0.06992336,0.027556743,0.014162628,0.077558465,-0.06437303,-0.013766773,-0.010398715,0.026423119,0.007199269,-0.08833302,-0.03715845,0.053076036,0.123632774,0.008354027,0.07887933,-0.0775328,-0.041409478,0.03232401,-0.020473814,-0.015273691,0.04282933,0.007781246,0.023944482,0.007427506,-0.0011757517,-0.007915444,0.03376188,-0.017059462,-0.016607797,-0.015319985,0.045611046,-0.09361347,-0.00359147,0.003458999,0.0005255749,0.029107496,0.034098342,-0.095801085,0.049030546,0.043470073,0.011636833,0.037901565,0.008396058,-0.030991945,0.015108051,0.028577216,0.04413612,-0.051767536,-0.033710726,0.034924664,0.03478929,-0.04102044,-0.034602143,0.014659418,-0.06125707,0.020571254,0.03338999,-0.027307875,-0.055858422,0.07749603,0.016504792,0.100794785,0.0731071,-0.053935323,0.10422929,-0.04368678,0.026778042,0.017858772,-0.120190725,-0.02264061,0.024081891,0.0024434323,-0.044551127,0.05320413,-0.04365342,-0.11404237,-0.047042795,0.06500505,0.04842401,-0.025546942,-0.0136377355,0.02364116,-0.025134368,-0.07118463,0.059685636,-0.013465164,-3.2751164e-08,0.023642827,-0.035845254,-0.020554481,-0.010555917,-0.08655653,-0.0034220945,-0.0044250004,-0.0054846625,0.03704301,-0.05513523,-0.0020661114,0.060956758,-0.01262779,0.030610181,0.004298953,0.05241673,0.037339617,-0.0045740907,-0.034926157,-0.04518112,-0.06616262,-0.03163116,-0.046415813,-0.01475625,0.012711739,-0.07991755,0.03248651,0.07411839,-0.028843878,0.033838976,-0.027602375,0.0043673995,-0.0638537,-0.015206891,-0.06376958,0.08675305,-0.009254836,-0.05777657,0.04321387,0.079251945,0.099141374,-0.100481555,-0.020448525,-0.007109267,-0.07142609,0.024949802,-0.0339578,-0.07694088,0.0072005293,-0.020076541,0.026734738,0.028203484,-0.043998502,-0.057411622,-0.07674883,0.0017316642,-0.050356742,-0.03873819,-0.012474325,-0.10626686,0.010872208,-0.005526101,0.2319016,0.030282903 +2.3.1.163,"Acts on a number of related taxane diterpenoids with a free 10beta-hydroxy group. May be identical to EC 2.3.1.167, 10-deacetylbaccatin III 10-O-acetyltransferase.",384,1.0,-0.070834935,-0.04419928,-0.032695208,-0.006209938,0.002240363,0.041014187,0.04666775,-0.025485313,0.04747365,-0.03159794,0.11918619,-0.039925672,-0.048364215,-0.047253992,-0.018195858,-0.014456337,-0.05402947,0.038640827,-0.061106984,0.007843211,0.0674117,0.020731283,0.027144717,0.0031807756,0.009102304,0.0037453028,-0.010197225,0.021531228,-0.02965298,-0.14320102,0.01903247,0.00050132483,-0.044633657,0.011371174,-0.0005247326,0.011375042,-0.030237945,-0.07223356,0.03902924,0.051823676,0.12940569,-0.013486827,0.060311764,-0.047508057,-0.02188226,-0.054062128,-0.07397343,0.015845139,0.02111646,-0.0020196317,0.055623394,-0.024298439,-0.018300945,0.08697426,0.037541155,-0.027321601,-0.027656926,-0.0019435792,-0.049491484,0.0030614445,0.045248516,0.024503477,0.011891684,-0.004050472,-0.09175249,0.0022804718,0.0011110947,-0.06764952,-0.018432984,-0.02569864,-0.076504014,-0.10077668,-0.048944704,0.026854917,-0.011009122,0.035979573,-0.028242745,0.03837718,-0.042686723,-0.09750695,0.042782336,-0.04682097,-0.0025577694,0.10593831,0.00087766146,-0.022990126,-0.0036081611,-0.031902336,-0.01966127,0.09748647,-0.0009196581,0.017593408,0.043854516,0.0013706178,-0.07909236,0.0071759303,0.079427615,0.05708267,-0.043812178,0.045686364,0.00869461,0.04991012,-0.10477168,-0.06603166,-0.040046334,0.0063592,0.031741418,-0.04325907,0.011464086,-0.061767768,-0.00089622487,-0.06968362,-0.017610734,0.008399121,-0.08979893,0.03906776,-0.006214691,-0.107142456,0.080997825,-0.05379486,0.025078006,-0.050193727,0.09724613,0.050005767,-0.073054105,0.05689453,-0.038459532,1.7967156e-33,0.013082665,0.0024045852,0.0025537075,0.023883484,0.011039239,-0.0127470605,-0.11619515,0.08266645,-0.024586566,-0.15862991,-0.12063163,0.044115722,-0.006652704,0.040439423,0.0070551657,-0.051718544,-0.018283311,0.05394256,0.08455405,-0.062849745,-0.004740168,0.06993483,-0.06537366,-0.003959709,0.006093897,-0.013084086,-0.12092231,-0.0035974525,0.06809133,0.011716968,0.05601307,-0.028004719,0.019309737,0.024252815,-0.04495456,0.0058687516,0.052144937,-0.040873617,0.025357574,-0.02643926,-0.005053138,0.008731821,0.02925581,-0.034211148,0.032201465,-0.020707313,0.023343604,0.035201017,0.094741955,0.03732732,0.014091447,-0.020174207,0.11021981,0.020096434,-0.021603558,0.01201547,-0.03844714,0.06543507,0.037464812,0.09636412,0.03374928,0.11471323,-0.03604724,-0.030829856,-0.020246515,0.10241264,-0.03774182,0.001884119,-0.051348224,0.03685519,-0.07019017,0.02111719,0.1143064,-0.009838116,0.16583072,0.05342655,-0.046130598,0.007165473,-0.038306434,0.030305527,-0.039810292,-0.026328107,0.033928312,-0.037035067,-0.049636405,0.032444436,0.008152207,-0.0033081367,0.029427096,0.06701438,0.053966984,0.028965497,-0.09093182,-0.022343837,0.053163346,-3.1846464e-33,0.0039956174,-0.047313865,0.018373685,-0.028543908,-0.014493385,0.10472205,-0.01768526,-0.031360578,0.054944515,0.02752548,0.0517552,0.029747527,0.04115465,-0.12277012,0.06839514,-0.11907713,-0.08783017,0.08446142,-0.050281286,0.0038588254,0.061880622,0.055878755,-0.010664099,0.09183338,-0.0214716,4.3765744e-05,0.046346337,0.03642279,0.028186794,0.03142925,-0.04361443,-0.024340793,-0.07023422,0.038372423,-0.09310805,0.034551457,-0.042199746,0.024242876,-0.07950481,-0.009797598,-0.080297,-0.055011444,-0.032871783,0.066088185,0.092258394,0.0611281,-0.06647176,0.068163924,0.01875655,0.059986517,0.034258883,0.03777415,-0.015741237,0.038662545,0.024761962,0.01583267,0.010292206,-0.0052379803,0.04258501,-0.025320608,-0.00826305,-0.010968729,0.0018863447,-0.040459216,0.019607676,-0.029612798,-0.03580431,0.040102325,0.061676417,0.05178725,0.027100766,-0.025155261,-0.03785404,-0.056233294,0.043516025,0.0068556303,0.008683918,-0.104773164,-0.044827167,-0.04441305,-0.021330163,0.0023545795,0.032759987,-0.046354614,-0.037038352,0.007187955,-0.012074431,0.022584314,0.0016517991,0.07607183,-0.0050137127,0.049495846,-0.06413283,0.020008296,-0.041367516,-3.2714752e-08,0.06982637,-0.016523385,0.09608979,0.03949168,0.013004927,-0.030960925,-0.035661187,0.06707138,0.052585352,0.004641645,0.05057259,0.058399588,0.0056138206,-0.020769956,0.031533524,-0.045129683,0.04856503,0.052784506,0.00041605477,0.05244604,-0.090424284,-0.0072512995,-0.0446585,-0.015049441,-0.039354175,-0.09868538,0.04505625,0.019825282,-0.0017487919,-0.058828242,0.084175564,-0.014520047,-0.057056203,-0.012326961,-0.07735315,0.012261468,-0.07526782,-0.005986107,0.02642428,0.037409954,-0.024329977,-0.049215972,-0.057705395,0.046476804,-0.019694248,0.047416184,0.013224553,-0.017499236,0.012682089,-0.044127792,-0.010776431,-0.0037490807,-0.041000225,-0.05699252,-0.14167592,-0.020371826,-0.023619344,-0.025255386,0.027185928,0.0038471485,0.034219407,0.013462384,0.14779589,0.06542145 +2.3.1.164,"Proceeds by a two stage mechanism via 6-aminopenicillanic acid. Different from EC 3.5.1.11, penicillin amidase.",384,1.0,-0.047880743,-0.08970253,-0.005348264,-0.04166067,-0.002326996,0.007855439,-0.061578255,0.08079051,0.09244754,-0.023439303,0.0374923,0.0208856,0.02766862,0.046972226,-0.00410994,-0.023680858,-0.12441906,0.04536963,-0.025424547,0.0068502272,0.041362263,0.09368537,0.021004567,-0.053815313,0.04913556,0.0075683496,0.066449426,0.044128567,0.010456658,-0.06299318,0.05436543,0.014227249,-0.031223187,-0.08168316,0.030362548,0.029555997,-0.08138821,-0.056248575,0.09542409,0.037799068,0.061221812,0.0044118157,0.032261133,-0.082697056,0.026847657,-0.035394933,-0.014562053,0.08073076,0.109556414,-0.022059597,-0.012458042,-0.12859228,-0.020441197,0.045488145,0.004331812,0.021281417,-0.11101326,-0.054224033,-0.02360264,0.02098225,-0.0021246318,0.0699434,0.031349894,0.0012399426,-0.07591907,-0.016926369,0.04136673,-0.08783983,0.04579959,0.016554497,-0.087247916,-0.05738214,0.028991595,-0.010973024,-0.021654826,-0.023992864,-0.037539534,-0.03312793,-0.024390083,-0.0771389,0.022189945,-0.016005108,-0.054929752,0.10139568,0.005916528,-0.046531,0.07970828,0.0055938824,0.0039295927,0.00026666632,0.061634265,0.06146093,-0.061550137,-0.09485086,-0.14816602,-0.048519198,-0.04636728,0.0768452,0.027063182,0.024331447,0.016086098,0.07246438,-0.077220134,-0.105217785,0.022134814,-0.041590195,-0.009354705,0.041670393,-0.036311243,-0.05735136,0.010297323,-0.054581415,-0.008505824,-0.0364183,-0.03230957,0.09142866,0.0032413246,-0.040673055,-0.001100448,0.04768,0.024923893,-0.038813062,0.039417986,-0.0046795285,-0.03382452,0.015993496,0.037496556,-2.4595417e-34,-0.034112457,0.015400384,0.010915372,0.0025586404,0.028931132,0.017246246,-0.071610644,-0.019734785,-0.040930014,-0.08114094,-0.042665716,-0.008942942,0.01389645,0.019765535,0.04684877,-0.029979235,0.025372399,0.072716184,0.037930887,0.01721486,0.061442915,0.04844852,0.020677546,-0.032163355,0.047432598,0.034169357,0.0075154193,0.05771022,0.11580426,-0.02666724,-0.03268622,0.004204839,-0.04852806,-0.008993036,0.004569792,0.019116614,0.0031753243,-0.04132892,0.02535938,0.06259269,0.03454792,0.03290266,-0.024961876,0.004286184,0.0219546,0.028612627,-0.060464196,0.10678576,0.047148563,-0.012894122,0.102287576,-0.05977555,0.12412536,-0.042611815,0.0035211882,-0.057918664,-0.0815574,-0.011608993,0.0076693976,0.029595176,0.002294886,0.003395356,-0.03742131,0.06136161,-0.048344072,0.055629242,-0.045335762,-0.02330281,0.030913336,0.035467952,-0.093137704,-0.001288288,0.0393601,0.036905613,0.038576078,-0.017105158,-0.1090111,-0.02445488,0.046059836,0.015229294,0.0017735463,-0.00454253,0.025623925,0.0347996,-0.03502771,0.01106317,-0.04503173,0.025318049,0.021419575,0.0016266265,0.01703067,-0.061273772,-0.06770232,0.061835337,0.014501495,-8.3737855e-34,0.10667106,-0.049669415,-0.023383908,-0.019884424,-0.060961254,0.072028734,0.0018196402,-0.011179563,0.039196752,-0.025331344,0.00784261,-0.0037863383,0.05856426,-0.047676492,-0.043399647,-0.049607933,0.04286342,0.088619806,-0.021678837,0.0042151753,0.0075979824,-0.058861185,-0.019221356,-0.0141455885,0.03927263,0.055513628,-0.021336867,0.019108834,0.016165085,0.085131556,0.008712772,-0.033973582,-0.023730809,-0.002432602,-0.068136446,0.12284352,0.041524347,-0.07088945,-0.010254067,-0.01871171,0.012549268,-0.023681823,0.05481289,0.07678436,0.017454075,-0.0017813129,0.044562627,0.046430424,-0.1118419,-0.091688834,0.034320142,-0.08199073,-0.008826556,-0.018623013,-0.005196889,0.009239358,0.05604445,-0.11002825,0.0713312,-0.001971145,-0.0018738371,-0.044262227,0.0056147566,-0.022988474,-0.047535077,0.019036284,0.0038860445,0.061479714,0.051314924,-0.043443844,0.03247163,0.04712292,0.03772761,-0.021001102,-0.0073539643,0.117915295,0.027222427,-0.119063765,0.06717571,-0.05171447,-0.038117852,-0.09910933,-0.052155312,0.0056721237,-0.063513905,-0.02659687,0.09403906,0.050017387,-0.022006173,0.032144003,0.012263673,-0.0032566544,-0.0014455614,0.093938485,0.05240783,-2.7774893e-08,0.09133281,-0.067086436,0.04033914,0.026265556,0.03517178,0.04442695,0.023795286,0.00950902,0.050528962,-0.045999806,-0.06042477,0.015921967,0.01592243,-0.0048718555,-0.05426311,0.07348462,-0.044132225,0.04944016,-0.04521913,0.030376075,-0.061217066,-0.025297971,-0.06219447,-0.084450044,0.042493608,-0.07574932,0.02565087,0.09540956,-0.101299815,-0.033271264,0.0040501617,-0.029310746,-0.05617769,0.0007042054,0.014692891,0.00785887,-0.02192724,-0.0016423771,0.030354451,0.01939933,0.027661392,-0.026614862,-0.12965721,-0.021547083,0.025270328,0.033543088,-0.053463817,0.0010177086,-0.07418181,0.028137797,0.061222516,-0.036408473,0.0401731,-0.028476963,-0.055423915,-0.0025308907,0.0051341346,-0.07975325,-0.03885294,-0.040037587,-0.05547673,0.033530008,0.18972507,0.07656628 +2.3.1.165,A multienzyme complex with a tightly-bound 4'-phosphopantetheine cofactor on the acyl carrier protein. It has a similar sequence to vertebrate type I fatty acid synthase. Acetoacetyl-CoA can also act as a starter molecule.,384,1.0,-0.089399755,-0.097257726,-0.12502724,0.009845442,-0.0013233186,0.0666312,-0.04090734,-0.0029045744,-0.030710619,-0.03521457,0.0949314,-0.11159116,-0.057504542,0.045772094,0.00076581445,-0.0015816998,-0.042036626,-0.019736499,0.019251881,-0.09295491,0.016956223,0.06760961,-0.0013862121,-0.02194931,-0.020835092,-0.036084816,-0.005001901,-0.0087752715,0.061350707,-0.089645445,0.025137985,-0.027314954,0.020458417,0.008973425,0.052727904,0.028453123,0.018877931,-0.06622095,0.0888389,0.025181767,0.07755385,-0.0596995,0.00912273,0.043926522,-0.027845928,-0.08925958,-0.06677102,0.010114007,0.063793495,-0.033139423,-0.047312398,-0.03667834,-0.043020412,0.041276366,-0.011567598,0.111097574,-0.065720156,0.0154019045,-0.0015127696,0.0008017916,0.060907435,-0.01452712,0.024462132,-0.0072379247,0.0132932635,0.0019669593,0.036273025,-0.011765335,0.047652107,-0.0183215,-0.033295307,-0.09213663,-0.08839422,0.11846702,0.03333329,0.0444474,-0.080450326,-0.044830345,0.030720998,-0.019373564,-0.01810555,-0.006758277,0.013456376,0.026593896,0.009266624,-0.024178226,0.0344038,0.008121354,-0.01614584,-0.004247121,-0.023716662,-0.08503913,0.01691346,0.011209625,-0.04400544,0.09675107,0.059775658,-0.04376514,0.00803752,-0.011728625,0.045103576,0.058140278,0.02762793,-0.0084328065,-0.030708922,-0.04620357,-0.03322993,0.04686874,-0.046752654,0.016670248,-0.048381194,-0.028041298,0.07129049,-0.046201486,0.036382027,0.047322284,-0.03459507,-0.023487011,0.07044932,-0.0053830715,0.007868284,-0.015147313,0.0097713,0.055520132,-0.005665708,-0.019247286,-0.11571097,2.1402292e-33,0.06785132,0.07127332,0.0581358,0.06391427,0.0077770995,-0.08412452,-0.08987169,0.046148896,-0.016810594,-0.017778704,-0.010199505,-0.04026029,-0.01909103,0.079934955,0.015552724,-0.051758673,-0.034925085,0.021729648,0.029928787,0.007716255,-0.02239675,0.10190774,0.0052893823,-0.034469258,0.032395635,0.027664224,-0.033298183,-0.00056625647,0.04868715,0.04199028,-0.04209733,-0.036915198,-0.06787885,0.03164354,0.0031562364,-0.04604717,-0.032767,-0.116261505,0.0052668564,0.02592933,0.008809674,0.021290328,-0.024935212,-0.031572618,0.060909506,-0.015921753,-0.060496554,0.017829582,-0.03461357,0.011014502,0.0054398724,-0.010296018,0.07403897,-0.0030733235,-0.09147195,0.024405878,-0.06227039,-0.02842214,0.036298428,-0.019889103,-0.009324075,0.08052328,-0.05249002,0.039536197,-0.023001816,0.012541647,-0.09832751,-0.082269736,-0.046901353,0.11271316,0.03899965,-0.04777112,-0.009973,0.01597876,0.0984165,-0.0039447215,-0.01590256,0.008353494,-0.06761268,0.0073146317,0.0018175122,0.017033467,0.060983986,-0.02596609,-0.03189203,-0.061519776,-0.0039288895,-0.0069236364,0.033993207,-0.04592083,-0.0033003287,0.022438169,0.028909229,0.041692916,-0.005236547,-3.1611446e-33,0.11383375,-0.12994379,0.037037924,-0.12990563,-0.070539355,0.05629705,0.039728563,-0.013278681,0.042429153,0.03209008,0.0833747,-0.0038631759,0.01983721,-0.098791234,0.03472597,0.021185962,0.017724767,-0.020536788,0.07339283,0.015430851,-0.01629402,-0.052431524,0.015570911,0.08165064,0.041732006,0.04466589,-0.033449695,0.045888852,-0.049462873,0.03593513,-0.0038200675,-0.077551946,0.015980143,-0.06370101,-0.09754531,0.041033465,-0.057449594,0.016997324,-0.089282766,0.013035974,0.023576973,0.023680056,0.03123577,-0.004745691,0.07271031,-0.07094881,-0.020889618,-0.013101156,0.018085083,-0.10688029,0.022046445,0.0017569542,0.011426546,-0.051350705,0.02113859,0.10554443,0.03599895,0.028160479,0.01684582,-0.09080313,-0.074597254,-0.042766932,0.0027011854,-0.0070130904,0.0716763,0.029261388,-0.023596674,-0.023278374,-0.0044912077,-0.01658278,0.044083115,0.06604794,0.030322928,0.028576251,0.028739465,-0.10366001,-0.033213038,-0.02676556,-0.057036713,-0.050872628,-0.04227763,-0.076826915,-0.017218048,-0.049226806,-0.03771697,-0.0068779383,-0.017571483,0.0898637,0.03317279,0.057411443,-0.003231719,0.07081662,-0.068705715,0.079683125,0.0012911718,-3.447159e-08,0.0809156,-0.026664058,0.037902396,-0.03246198,0.0079707205,-0.016488686,0.0032772024,-0.08000489,0.05007606,0.029201461,-0.054781623,0.11174539,0.09148471,0.07687653,0.0018229979,0.060450085,-0.056951758,0.014648048,0.0034899483,-0.027276864,-0.02013812,0.016373038,-0.010033224,0.08457059,0.0234905,-0.011612804,0.07526783,0.044111338,0.0037151517,0.08765891,0.017161407,0.026021287,-0.0284622,-0.020466652,-0.007012154,0.026876155,0.088987276,-0.08497608,-0.048586216,0.031082578,0.036280807,0.07611071,-0.05129528,0.04262443,0.12690501,0.0076021343,0.012483156,0.0013720884,0.03325148,-0.030053532,-0.019872386,0.05711712,-0.06370636,-0.027313916,-0.07364051,-0.05210405,-0.05038044,-0.05221928,0.0078089978,-0.03170571,0.05117268,0.0056671724,0.24063167,0.002384155 +2.3.1.166,"The enzyme was studied using the semisynthetic substrate 2-debenzoyl-7,13-diacetylbaccatin III. It will not acylate the hydroxy group at 1beta, 7beta, 10beta or 13alpha of 10-deacetyl baccatin III, or at 2alpha or 5alpha of taxa-4(20),11-diene-2alpha,5alpha-diol.",384,0.99999994,-0.060434192,-0.088883355,-0.08855594,-0.0482229,-0.057263672,0.018617412,-0.019776078,0.000589561,-0.063582845,0.005072355,0.00313595,-0.063858375,-0.07481189,0.045812864,-0.07452442,0.00022102176,-0.056344233,0.042175315,-0.0120045785,-0.001138423,0.047297012,0.019177165,0.05110134,0.060785197,0.05447567,-0.024168922,0.055492572,0.038059816,-0.05432713,-0.10261207,-0.047016535,-0.00819743,-0.019508133,-0.032299068,0.0034742758,0.052921273,-0.02790616,-0.043014053,0.04472376,0.0151770245,0.03247829,0.041838583,-0.02299939,-0.010066071,0.006049673,-0.10645033,-0.04327922,0.028248983,0.15098807,0.0044761105,-0.005157952,0.022603897,0.011042679,0.10168366,0.014967006,-0.057718437,-0.046148468,-0.01094848,-0.028356602,0.020480787,0.007333206,0.06466574,-0.00029387264,-0.0105965035,-0.06408172,-0.052322276,-0.067513764,-0.058179613,-0.035411026,-0.012170018,-0.074261315,-0.13901834,0.02599981,0.027867591,-0.0053922026,0.0227506,0.011396391,-0.03186118,-0.009403161,-0.04533255,0.032143686,-0.026530037,0.0907458,0.17330417,0.028937435,-0.00023046433,0.03673261,0.0038818936,-0.0067932485,0.08159343,0.07810118,0.092266314,-0.025797088,-0.035446964,-0.02038087,-0.014902819,-0.040649712,-0.0019630385,0.01107149,0.085017964,-0.013621462,-0.009893034,0.0004917666,-0.07335318,-0.11306014,0.009729318,0.04482049,0.060157295,0.110774636,-0.050345447,0.013869687,0.030780943,0.042655256,-0.009812024,-0.081744246,0.0901397,-0.028938528,-0.08000071,0.04703299,-0.110205494,0.02688415,-0.04721221,0.099037714,0.037687182,-0.049203936,0.048629887,-0.04916604,5.4953365e-33,0.058018733,-0.075147055,0.005680633,0.014644618,-0.014227165,-0.008887292,-0.08865275,0.047571365,-0.08235095,-0.093670435,-0.05237885,-0.027456637,0.023140933,0.010430816,-0.00784812,-0.037310097,0.058975495,-0.0151501335,0.08599338,-0.025940169,0.025169637,0.06592442,-0.0416835,-0.0137568815,0.0631525,0.024344642,-0.014825151,0.06722642,0.036593582,0.02856291,0.035510678,-0.06011048,-0.03241402,0.028278653,-0.015072022,-0.03241418,0.0073839095,0.018063042,0.05163846,0.056941126,0.090201415,-0.026175503,0.07658307,-0.07352816,0.049216487,-0.022999803,-0.008131086,0.12594411,0.050055705,0.094333746,0.0855712,-0.011554963,0.060842168,0.023923812,-0.05572721,0.1010717,-0.016228618,-0.0026995118,0.103247814,0.072190076,0.007185445,0.0348915,-0.023388429,0.00064407155,0.04208775,0.03339775,-0.026784798,0.019471377,-0.0693657,-0.02496665,-0.06730028,0.02426414,0.08810472,0.009471008,0.07404405,0.022219727,0.00020373908,0.024986813,0.01176563,0.016375726,0.027474388,-0.028547363,0.0029034354,-0.03475612,-0.03693844,0.0717104,-0.042992547,-0.031092934,-0.036422092,0.0026797543,0.03922307,-0.03566987,-0.0570174,-0.006871337,0.035928905,-6.421336e-33,0.06633656,-0.09940315,0.020426746,-0.08114375,-0.04959228,-0.00499317,0.09129231,-0.0443832,0.017716834,0.018874167,0.0775155,0.013366832,0.027320378,-0.028930202,0.014169152,0.0023913565,-0.05370498,0.0858908,0.0005543635,-0.015957285,0.048505094,0.081083745,-0.030516066,0.061810113,0.046050668,-0.036182318,0.041609515,0.075582966,0.041838344,0.020806171,-0.045102682,0.007142283,-0.024034198,-0.028263856,-0.10946428,0.027080238,-0.06732369,-0.062016472,-0.06636265,0.002193803,-0.053121816,0.0069228406,-0.054440994,-0.025330754,0.07318584,0.06691531,-0.013422808,0.036910713,0.044950698,0.04586837,0.002936293,0.043768216,0.08075508,-0.006220892,-0.050333824,0.02712451,0.029534735,0.0021299364,0.063182406,-0.025905266,0.060461044,-0.030941075,0.087384574,-0.007169271,0.016056934,0.05987611,-0.055754405,0.017247822,0.055834502,-0.05854661,0.0014093496,-0.0738159,-0.0051855296,0.065929025,-0.042027827,-0.0069279694,-0.0029552723,-0.033744432,0.0023223376,-0.0037153268,0.009478393,0.011195522,-0.0388966,-0.09621822,-0.0002421614,-0.023807043,-0.0008504064,0.040577594,0.008242901,0.031556003,-0.00056162255,-0.009941388,-0.025107764,-0.016870316,0.01730588,-4.9497864e-08,0.067976974,-0.11103364,0.05390746,-0.04485302,-0.0072146426,-0.0030537997,0.0041413424,-0.015976634,0.037722092,-0.07979673,-0.025731415,0.066040866,-0.049722046,0.033594463,-0.052040372,0.029022422,-0.020702446,0.00457305,-0.012731605,0.0071153557,-0.03407397,0.0061901794,-0.09551965,0.058409326,-0.05939143,-0.09038099,-0.069423795,0.0373919,-0.022410654,-0.063260324,-0.030019639,0.0658304,-0.02039756,-0.09076876,-0.06152204,0.0071306094,-0.10505202,-0.016575472,-0.007655917,-0.013702986,0.06962989,-0.06140847,0.034877755,-0.024303218,-0.02175226,-0.029043723,0.018602856,0.078279346,0.06469506,-0.005480709,0.07885347,0.017006874,-0.068462595,-0.09867955,-0.06288171,0.012016261,-0.041281387,-0.06432716,-0.018941766,0.0005567725,-0.018152606,-0.044349644,0.14963356,-0.061920494 +2.3.1.167,"The enzyme will not acylate the hydroxy group at 1beta, 7beta or 13alpha of 10-deacetyl baccatin III, or at 5alpha of taxa-4(20),11-dien-5alpha-ol. May be identical to EC 2.3.1.163, 10-hydroxytaxane O-acetyltransferase.",384,1.0,-0.061500054,-0.096270576,-0.063632354,-0.02306993,0.0010418423,0.009457461,-0.043620687,-0.0147297615,0.00024011504,-0.076399624,0.06409834,-0.07606463,-0.03423641,-0.029337611,-0.061193623,0.025210423,-0.08901756,0.024586579,-0.027221987,-0.04290567,0.074406706,0.012518738,0.059176788,0.023260666,0.025543276,-0.036001585,0.008032275,0.027609011,-0.027961077,-0.16781378,-0.007421593,-0.013237279,-0.049823552,-0.034708746,0.03126202,0.02963062,-0.009054922,-0.076062426,0.05240415,0.05720191,0.060823563,0.008958613,-0.03303332,-0.07159842,0.005927732,-0.08809239,0.013639259,0.003613404,0.07097614,0.0044527873,-0.010865591,-0.027689936,-0.043209523,0.06333787,0.016221961,-0.044618208,-0.07005599,-0.021040428,-0.0030602096,0.04458538,0.023844454,0.04966368,0.002883371,0.022582833,-0.041424613,-0.021540925,0.030410126,-0.12311481,-0.060026743,-0.009119395,-0.105748475,-0.12313605,0.039130345,0.08932278,0.01994444,0.020702371,-0.024653792,-0.056808453,0.0065907813,-0.02867058,-0.009263689,-0.05923865,-0.0346574,0.09254034,0.020297946,-0.046145994,0.01928974,0.026041895,-0.016604887,0.08056777,0.0017979549,0.042893782,0.035552863,-0.03031646,-0.009775941,0.020423902,0.025332585,0.061520644,0.015633645,0.03268199,-0.023440149,0.053348567,-0.032537572,-0.027328119,-0.072494194,-0.020514658,0.061063223,0.057590906,0.06976846,-0.06735832,0.012815087,-0.0555071,0.04359947,-0.03013565,-0.05364297,0.0982852,-0.06156904,-0.11433099,0.020857051,-0.0724448,0.026745047,-0.05720045,0.10565557,0.095671825,-0.056052156,0.087656945,-0.085323125,3.3407057e-33,0.04010861,-0.0008215982,0.056106158,0.028515762,-0.004238644,0.00959801,-0.09813778,0.041089267,-0.036742367,-0.10211829,-0.06824658,-0.021009421,0.019636946,-0.009137763,0.0065069064,-0.022486893,0.0011462148,-0.022651143,0.032487392,-0.02425524,0.06336891,0.039642725,-0.07822204,0.038361493,0.013613669,-0.00940412,-0.020721732,0.03873041,0.056964666,0.02827692,-0.017235612,-0.075669974,-0.046548203,0.02310951,-0.021042034,-0.01895787,0.055616036,-0.016546518,0.06278362,0.028021248,0.064335085,0.04125117,0.09195858,-0.0599607,0.05790829,-0.021954447,0.0025110994,0.09545866,0.08036132,0.08678188,0.025108675,-0.011053774,0.08635449,-0.0022433882,-0.011181357,0.055742398,-0.05007439,0.04711453,0.057602122,0.085756704,0.03735042,0.050694294,-0.029424628,0.011414319,-0.03123486,0.07855955,0.0116460305,-0.0038436481,-0.050470814,-0.012377935,-0.06021346,0.033174895,0.10465216,0.030733204,0.11024404,-0.005670801,-0.031694088,0.032181762,-0.0037254957,0.010961518,-0.007946063,-0.008409658,0.009610107,-0.008387507,-0.04132767,0.023845468,-0.004406622,0.047901914,0.021159798,0.05965542,0.084999435,-0.048065927,-0.04766004,0.02089597,0.008998428,-4.008791e-33,0.052100733,-0.0832078,0.034500323,-0.10796027,-0.053187117,0.039740603,0.11460517,0.024372403,0.041808523,0.0068339594,0.12577371,0.02904296,0.042428438,-0.093376085,0.05199034,-0.08749075,-0.05476049,0.08325201,0.009573708,0.032885592,0.03679753,0.043782096,-0.054207217,0.081518225,0.048520908,0.057848927,0.0047042374,0.058341857,0.06299531,0.016742093,-0.0699682,0.02788205,-0.04922338,0.0046287463,-0.10733173,0.0007414365,-0.036477312,0.0050627217,-0.08773208,-0.0067020967,-0.07192778,0.011454069,-0.043170903,0.0063717146,0.06522278,0.10187017,0.01801896,0.04283582,0.021404203,0.022446485,0.0032834408,0.056949638,-0.0039479407,-0.014080705,-0.03238208,0.031897727,0.039401475,0.020535968,0.040341064,-0.06027371,0.0062573818,-0.020333953,0.09197826,-0.041973747,0.0013800088,0.045111958,-0.044249024,0.05699288,0.03243097,-0.0066652657,0.011245978,-0.07752667,-0.02860219,-0.0070914184,0.029610468,-0.01222582,-0.03256699,-0.041864254,-0.019409293,-0.04750855,0.008501288,0.014634723,-0.011189807,-0.06857686,-0.003051434,0.019909058,-0.0006080281,0.041237786,0.03572085,0.05208586,-0.048878293,-0.009898944,-0.06794546,-0.020791266,-0.020273536,-4.2081883e-08,0.037973218,-0.045087166,0.10089662,-0.0013574015,0.023487708,0.011602245,-0.03510469,0.02251025,0.084780954,-0.06167878,-0.025888456,0.08347696,0.007825388,0.0005000767,-0.07147044,-0.026576225,-0.0022348722,0.036597885,0.024116026,-0.0040126685,-0.09624035,-0.005167316,-0.06847463,0.08058609,-0.038096547,-0.06351407,-0.03129147,0.05148794,0.0018601145,-0.08242218,-0.009150212,0.010048623,-0.03365519,-0.05456888,-0.10204796,-0.022290137,-0.08045795,-0.00020735015,-0.02890721,0.0058478042,0.053837076,-0.087805025,-0.007486657,0.007271785,0.05173718,-0.00037923685,0.004965603,-0.00029079494,0.06829573,-0.051805303,0.06575338,-0.03844026,-0.055445045,-0.10233682,-0.06689881,-0.063266315,-0.046997882,-0.055800185,-0.006536701,-0.010487162,0.044815402,-0.027488204,0.17306755,-0.0055448725 +2.3.1.168,"A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC 1.2.4.4, and the only observed direction catalysed by EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to coenzyme A. In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC 1.2.4.4 acts on the oxo acids corresponding with leucine and isoleucine.",384,1.0,-0.060312923,-0.09160205,-0.087240115,-0.049220927,0.10366379,0.020850753,-0.0976064,0.018380014,0.0039961427,-0.05020087,0.044247225,-0.10595728,-0.06513193,-0.071431704,0.016384603,0.057312213,-0.075340785,0.023277784,-0.062303588,-0.04102958,0.10026956,-0.038455654,-0.04799537,-0.001730831,0.0011373801,0.09011399,-0.0027154775,0.021485655,-0.014290824,-0.10365712,0.040124964,-0.06509288,0.01975888,-0.0533398,0.0020043796,0.063974634,-0.032836825,-0.07612286,-0.008395272,0.086137906,0.05547704,0.03467654,-0.027609006,-0.053968124,0.0014609095,-0.058791533,-0.0054630833,-0.002689565,-0.0018759937,-0.04175922,-0.009008566,-0.09751756,-0.024884716,0.08452052,-0.04175811,0.057865206,0.017267654,0.035484374,-0.074592635,0.038137246,0.021711143,-0.0025156618,0.031222146,-0.03747225,-0.0072106635,-0.042144034,0.051948644,-0.09899651,0.027331123,-0.05137582,-0.111382715,-0.069242306,-0.012712299,0.030630738,0.0057225656,-0.015951345,0.021166222,-0.0036551843,0.026911309,-0.105086796,0.0045581753,-0.006989223,-0.002080194,-6.051349e-05,0.041075453,-0.01457372,-0.03992615,-0.049265206,0.08837998,0.10995932,0.016770743,-0.011358722,-0.022711419,0.04042193,0.02684969,0.07087208,0.029989667,0.094267674,0.028675705,-0.033180304,0.02961024,0.07442982,-0.08751462,-0.07976854,0.00973304,0.058316097,0.0066135987,0.043187104,-0.0385159,0.01028521,0.012325398,-0.025954144,0.09631988,0.013399376,-0.025466315,0.09464709,-0.0030143769,-0.025487592,-0.008485884,-0.04596792,0.040926956,-0.041790333,0.15166913,0.027722131,-0.009897713,0.032447226,-0.15369533,5.4352563e-33,0.05851958,0.04322015,-0.03191837,0.053827014,-0.03260451,-0.017121399,-0.115184486,0.11726506,-0.05069127,-0.047875278,-0.03859332,-0.050009847,0.08979343,0.017313056,-0.0642651,-0.072106324,0.0036362296,0.029758891,0.02334073,0.025536917,0.036943194,0.0346449,-0.064663686,-0.014388869,0.0012793661,0.044437338,-0.0066888207,-0.039239213,0.03553688,0.04153116,-0.06556932,-0.10013618,-0.04683858,0.032619115,0.03458935,0.0057205255,-0.0057966174,-0.03200902,0.030059995,0.06903712,0.028439574,-0.012909223,-0.01702841,-0.03735195,0.062176418,-0.07393704,-0.05374582,0.08196518,0.09116564,0.018444316,-0.009370079,-0.08936717,0.13821355,-0.021552851,-0.063694544,0.016384268,-0.08825145,0.04178191,0.049764864,0.09146313,-0.022267736,0.09943317,-0.036504023,0.01878851,0.03764165,0.02707731,-0.09251044,-0.040960632,0.012560256,0.017775213,-0.032873414,0.039189883,0.09250307,0.0453602,0.058148626,-0.039339997,-0.040924903,0.06457828,0.044893306,0.008330446,-0.0359408,0.08157735,0.020449728,-0.047673568,-0.029548816,-0.00032317883,0.010366147,-0.057303816,-0.031392593,0.07879463,0.01534882,-0.04475155,-0.011344785,-0.01336662,0.044121716,-5.7323463e-33,0.071181126,-0.030806543,-0.014372675,-0.075300746,-0.031661022,0.05794799,0.05210706,-0.03578304,0.012513117,-0.008450033,0.10370799,-0.009030538,0.005852701,-0.059279814,0.014203543,0.010171725,-0.0466794,0.025904924,-0.006523698,-0.061365437,0.06394653,0.00976346,-0.017540112,0.098260604,0.017969077,0.0026763468,-0.019050524,0.012381283,0.06458131,0.072499216,-0.011305682,-0.015966462,-0.014933824,0.025987888,-0.023531293,0.085039675,-0.11788195,-0.010326994,0.0011630227,0.07440086,-0.054165024,0.020894418,-1.2377595e-05,-0.0001624594,0.03383469,0.05618378,-0.109955855,-0.019241842,0.02709125,-0.062905036,0.026345536,-0.025302755,-0.030239318,0.07057698,-0.0018217008,0.06319061,0.04069246,0.053017575,-0.023797186,-0.058156192,-0.03186746,-0.04014331,0.042133108,-0.008672744,0.037966557,0.025565058,0.016373409,0.009468796,0.034026407,-0.011953439,0.025367757,-0.017936781,0.024665935,-0.011947117,0.007029575,-0.054144714,-0.042227678,-0.020739218,-0.07189745,-0.054289427,0.0152714765,-0.05474063,0.034588434,-0.08818026,-0.0554939,-0.049372885,0.036401007,0.103653654,-0.03561565,-0.007149037,-0.019316258,0.0011852863,-0.08473509,0.058780715,0.09102165,-5.7051388e-08,0.017079594,-0.039385602,0.04879289,0.01874901,0.043254964,0.06320838,-0.03620486,-0.02469974,0.058634955,-2.2362301e-05,-0.012788297,0.06001124,0.03070347,0.016953576,0.020192482,0.020532593,-0.046427477,0.038351,0.015426494,-0.01760555,-0.016507735,-0.027752396,-0.10176463,-0.02783603,0.034854382,-0.06998021,-0.028448835,0.04744498,-0.005181918,-0.014089338,0.013652004,0.019730065,0.00040454767,-0.025739593,-0.05255611,0.007225543,-0.031435825,-0.014364373,-0.0559649,0.090488434,0.066228755,-0.03987178,-0.09806885,0.039646067,0.10047313,-0.0026000345,-0.027574733,0.03287635,-0.039529655,-5.422221e-05,0.035986204,-0.013386831,0.05738407,0.014134595,-0.054582797,0.011989724,-0.07049314,-0.07967515,0.049051538,0.0038520843,0.0060902745,0.038078245,0.12418965,0.011342268 +2.3.1.169,"Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.",384,1.0,-0.07288922,0.032024078,-0.08981548,0.041414704,0.14720938,0.0550336,-0.060257487,-0.034838673,0.004101273,-0.06551767,0.031214705,-0.13932602,-0.058055326,-0.068423815,-0.043843567,-0.036996704,-0.029573467,-0.034898154,0.0066764005,-0.062373962,-0.040865783,0.02463684,0.01573399,-0.013275813,-0.032710932,0.1379832,0.016831039,0.009338759,-0.036650185,-0.12279207,0.021677686,-0.029102573,0.073791675,-0.020992648,0.01704002,0.044173233,0.045250118,0.011946712,0.027773155,0.026453437,-0.025955774,-0.022635553,0.050157223,-0.04740988,-0.02218829,-0.065676935,-0.0041259537,0.008192174,-0.006648554,-0.031235017,0.0063902754,-0.031181032,-0.021506032,0.063683584,0.10472575,0.012848929,-0.027891997,-0.057690367,0.0070657884,-0.01741557,0.06555623,-0.014768162,-0.023975462,0.011136869,-0.0076415506,-0.005838046,0.076933846,-0.07146742,0.0036672342,-0.054849748,-0.023031069,-0.029655702,-0.029812295,0.029488234,-0.05592037,0.14694425,0.048335474,-0.12141013,0.094972484,-0.015049537,-0.026088867,0.056473024,0.035605762,0.07422932,0.041364603,0.040466797,0.0021909783,-0.039695628,-0.09542653,-0.042430874,0.0051274206,-0.008104946,-0.050075397,-0.014574993,-0.0049563884,0.09829818,0.05334637,0.065910086,0.04644437,-0.008998099,0.0050594835,0.122689284,-0.016225943,-0.13276584,-0.059609544,0.006795916,-0.014254052,0.14738633,0.08170121,0.027621867,-0.037487637,-0.09359955,-0.0044690664,-0.011128902,0.014855839,0.03276579,0.07268717,-0.030528655,-0.028398043,0.043978307,0.0903656,0.015914084,0.028249031,0.11189652,0.028948288,-0.025100619,-0.096824124,1.7471615e-34,0.07797014,0.01337786,0.061541297,0.01990515,0.013400632,-0.046391238,-0.1281738,0.049159873,0.002566707,-0.0036481684,-0.07171997,0.024482833,0.08836526,-0.026340574,-0.033873018,-0.078356944,-0.039606612,-0.04293804,0.041675553,-0.056973465,-0.042044576,0.08282718,-0.03276357,0.045259647,-0.03955822,0.040619716,-0.030563196,-0.012172929,0.060326878,-0.0044664196,0.030894006,-0.016073706,-0.025121734,0.024857093,-0.01805445,-0.008998051,-0.02398727,-0.014167237,-0.016983274,0.072812065,0.07069085,0.035822887,0.017092723,-0.058204945,0.023292849,-0.09831135,-0.088527784,0.079174414,0.05832288,-0.0128620565,0.01506824,-0.0026709128,0.041576724,-0.010933681,-0.051843267,0.056598227,-0.031242313,0.024960523,0.077183135,0.05794128,-0.01932381,0.07941481,-0.010868883,0.030035399,0.020549593,0.037441865,-0.033194814,-0.019028423,0.0015578712,0.027855186,-0.0433434,0.029114494,0.109553345,0.033381715,0.042157684,0.0012694763,-0.061525915,-0.034087688,0.044832814,0.011482461,-0.045935333,-0.036818016,0.0045222864,-0.018930634,-0.02257528,-0.01795494,-0.04991527,-0.04060861,0.014999004,0.016134305,-0.07780705,-0.039947618,-0.0421543,-0.091719754,-0.032606278,-2.134241e-33,0.057300005,-0.036212746,-0.017465739,-0.1057163,-0.046446227,0.0697758,0.0040364945,-0.06020917,0.023964206,0.051496625,0.1469096,-0.035048813,0.08800934,-0.08782259,0.031239381,0.03723081,-0.015035612,0.06750048,0.0617678,0.0194078,0.021402529,-0.024840793,-0.0021201016,0.034795832,0.097074814,0.026851295,-0.0507818,-0.07264544,0.1112745,0.07634387,-0.035919294,-0.009267217,-0.0150989,-0.007086957,-0.08011325,0.004560373,-0.0538028,0.01710757,-0.00122037,-0.047681116,-0.037828125,-0.026369452,0.0064223683,0.07972281,0.088554345,0.017674305,-0.011752272,0.028691078,-0.061214533,-0.0027291493,0.023726327,0.028763054,-0.09533521,0.0030692262,-0.016345134,0.101377316,0.0035109331,0.041301776,0.035953756,0.003752954,-0.028364921,-0.030792313,0.016351346,-0.01608986,0.038070068,0.021308055,-0.07680946,0.051840574,0.027048413,0.007751632,0.03337044,0.020353176,0.08573814,-0.03253496,0.0069754324,-0.0871933,0.0025200697,-0.02761922,-0.0382016,-0.015138381,-0.003772078,0.032071743,-0.00351935,-0.022790883,-0.04597428,-0.0053896643,-0.010879975,0.08218975,-0.0040939813,0.005924138,-0.08969317,0.015583385,-0.052060205,0.05843966,-0.022693276,-3.2638688e-08,0.001331922,-0.02628364,0.089954965,-0.03427927,0.04534641,0.06924685,0.11484968,0.008410424,-0.019619362,-0.012462355,0.018903196,0.10883593,0.012416729,-0.05855231,-0.006435506,0.0149555495,-0.0067832894,0.026556997,0.004979777,-0.012610739,-0.04231753,-0.01896667,-0.02871921,-0.0015476845,-0.040421028,-0.09132085,0.011004524,-0.029058207,-0.061987024,-0.030429874,-0.032734312,0.026871668,-0.0046062744,-0.074436,-0.011233043,0.0065345084,-0.034055505,-0.019942576,-0.0624602,-0.031111253,-0.032565378,-0.0042217826,-0.045974344,-0.008258348,0.047333468,-0.025329584,-0.009834591,0.044191528,-0.006606188,-0.04657842,-0.018786728,-0.005237258,0.016643519,-0.053348973,-0.05691532,0.049875926,-2.1499678e-05,-0.10879763,0.061596338,-0.019290164,0.012184966,0.013284322,0.14539586,0.0035646008 +2.3.1.247,"Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). It is involved in the anaerobic fermentation of lysine. cf. EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase.",384,1.0,-0.0681918,-0.037234947,-0.09522719,-0.009726599,0.09466302,0.014394512,-0.10107934,0.012698543,0.025226336,-0.030988902,0.022600897,-0.13156515,-0.026828812,0.025103973,-0.066720665,0.054235313,-0.067311995,-0.029004166,0.048064712,0.003626269,0.04321062,0.11281722,-0.00564544,-0.0024115564,0.037627872,0.028595118,0.035890102,-0.0017871715,-0.037483964,-0.07484262,-0.027747056,-0.069983765,0.13359155,-0.047367815,0.110858396,0.08043596,-0.07494049,-0.055461217,0.13340043,0.076219656,0.012979301,-0.0033069346,-0.026208721,-0.056871127,-0.007868009,0.014676089,0.033740055,-0.035039354,0.039405763,-0.0037426637,-0.024251536,-0.07961898,-0.016247474,0.06019723,0.030058328,-0.040681478,-0.07524875,-0.004451791,0.009772328,0.071873605,0.015922356,0.06825052,0.008395887,-0.017734827,0.026112134,-0.0725977,0.015354472,-0.059908714,0.043224033,-0.056495477,-0.082420856,-0.07129053,0.016029404,0.03259307,0.00095000054,0.010297932,0.032607384,-0.016706377,-0.014692819,-0.026148383,-0.008566738,-0.046852794,0.0039555863,0.02055613,0.038170114,-0.041410245,-0.049733184,0.01625079,0.017629247,0.04430211,0.025639987,0.015173452,0.016030326,-0.07866354,-0.03293529,0.01805303,0.0145557625,0.067051895,0.008277049,0.013539142,-0.0049606105,0.097161055,-0.0139302565,-0.096969806,-0.0144996885,-0.0022703737,0.08844947,0.035987165,0.010717907,-0.022979831,-0.0049704346,-0.010789407,0.054487538,-0.028252238,0.049780585,0.09855169,0.052856207,-0.040540792,-0.020772802,0.024108378,0.029384067,-0.07390142,0.085866615,0.07426839,-0.05458628,0.08724215,-0.089954875,4.1593736e-33,0.056254495,0.05560999,-0.005443189,-0.009004652,0.022547157,-0.0471327,-0.07901816,-0.0047661113,0.05061904,-0.08279386,-0.07178683,-0.044735502,0.077508934,-0.027915312,-0.039015923,0.018598499,-0.0651378,-0.025682518,0.058371745,0.052493367,0.026766596,-0.040227823,-0.002616986,0.028321601,0.023124466,0.02979637,-0.011372793,0.0012507966,0.07041966,0.0036961264,-0.017630816,-0.10802861,-0.029253976,-0.03394487,0.019558042,0.016757688,-0.053024977,-0.02492637,-0.0326144,0.013218264,0.017524034,0.039469153,-0.04132298,0.0016475286,0.025443481,0.034047324,-0.058465198,0.13096865,0.047747605,0.02492968,0.04941863,-0.074513674,0.037759013,-0.07582744,-0.043941587,0.055042326,0.0058441753,0.016061088,0.0314741,0.07501663,0.024809953,0.0783387,0.009455045,0.035743196,-0.0040056664,-0.01988239,-0.11816746,-0.0055502723,0.057997603,0.0015484918,-0.11703639,-0.037074067,0.07388049,0.02520493,0.037901185,-0.06840544,-0.11273892,-0.05564412,0.037992403,-0.021390986,0.037682615,-0.062172573,0.045128535,-0.07860412,-0.028517103,-0.053153485,-0.04331077,-0.029349329,0.005484608,0.015121371,-0.027907351,-0.063093975,-0.02678186,0.04403499,0.008386928,-4.0390092e-33,0.11310502,-0.045451462,0.0357005,-0.08437144,-0.028642595,0.0703649,0.0207184,-0.023992835,-0.009845787,-0.003026832,0.07666331,-0.024919495,0.086118035,-0.007669818,0.054705348,0.025908012,-0.02359871,0.051776484,-0.023773694,-0.029104315,0.033072058,0.043412585,0.039004255,-0.005284784,0.051581826,0.07861501,-0.05936409,0.09284199,0.08969454,0.05401485,-0.040270116,0.05631409,-0.027805956,-0.10401877,-0.0593656,0.049616642,-0.014386983,-0.029898347,0.01858999,-0.011939369,0.023686146,0.0058943164,-0.0632038,0.045657374,0.0014731135,0.08271792,0.03264709,-0.05816672,-0.00065251783,-0.07191376,0.033474077,-0.018029636,-0.10168496,0.0168486,0.018893879,0.061919466,-0.033707876,0.08530023,-0.038469635,-0.057908315,-0.0598101,-0.06248186,0.030249385,-0.017618788,0.067222334,0.017123656,0.01306353,0.13609375,0.023037555,-0.025020763,0.051973283,0.044974267,0.06547354,0.026027238,-0.061502937,0.014097262,-0.061986584,-0.08418236,0.006724764,-0.048623126,-0.033493616,-0.027647484,-0.035041012,-0.0075772875,-0.031188149,-0.05778455,0.034805223,0.06686292,-0.026781604,-0.020762177,-0.026109286,-0.013590778,-0.05454237,0.062402632,0.016507953,-4.5156835e-08,0.032147124,-0.09179828,0.04025472,0.020181267,0.059309646,0.03174941,-0.013035956,0.020080961,0.01712526,-0.04830154,-0.041674264,0.1067157,0.03588853,0.006351821,-0.0012169643,0.038954943,-0.02889248,0.066475525,0.005915676,0.0058300444,-0.029315013,-0.030139327,-0.04110676,0.048997767,0.02090469,-0.08656497,-0.021648116,0.07012653,0.017738158,-0.055735633,-0.02240297,0.022958018,0.037857533,-0.05363773,-0.072242424,0.003820447,-0.0476367,-0.05492132,-0.04697881,0.0188593,-0.006383197,0.009033198,-0.10278304,0.0136812525,-0.0017870745,0.01599932,0.007085746,0.08986035,-0.013812717,-0.043754544,0.042337995,-0.04974124,0.012205893,-0.014990114,-0.046181437,0.023347644,-0.027712695,-0.031332698,-0.0059878044,-0.04181794,-0.018992936,0.018141944,0.21733415,-0.033541165 +2.3.1.170,"Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone.",384,1.0,-0.0799965,-0.10069383,-0.074804805,0.029659122,-0.029608704,0.029515816,-0.041634664,-0.016734969,-0.0037696005,-0.013830867,0.09015342,-0.036908105,-0.032346535,0.015164118,-0.09739602,0.0070950133,-0.006561865,-0.018704709,-0.092888474,0.021411475,0.0016524845,0.02796253,-0.05755667,0.0024611019,0.04223859,0.0025714403,-0.0013478299,-0.0039635967,0.0971536,-0.0753461,0.03651105,0.04756977,0.004705529,-0.06534037,-0.013666072,0.045360543,-0.016394073,0.061170314,0.070693344,0.013814485,0.034033857,-0.07902071,-0.01211105,-0.025318831,-0.023216747,-0.075701475,-0.00393718,-0.015160494,0.060374845,0.008753097,-0.045835387,-0.035333153,-0.031486765,0.0760625,0.006655498,-0.119450584,0.03202722,-0.018822743,-0.036010724,-0.025699368,-0.06553233,0.014938121,0.02156357,0.03504613,0.005157348,-0.033940837,0.06250661,-0.04716772,-0.020758752,-0.06953558,0.012926736,-0.07130143,0.03893691,0.058638282,-0.08206831,0.08293699,-0.055490572,-0.051093373,-0.053996198,0.04554462,0.10322623,0.06725018,0.06681542,0.122817375,-0.048203625,-0.059537366,-0.04418546,-0.06742176,0.001717274,-0.033640206,-0.02916658,0.06981124,-0.004983828,-0.032554783,-0.0045576254,0.07698482,0.02200743,-0.017961891,-0.042911492,0.048467975,-0.05357672,0.017253468,-0.1305976,-0.02620259,0.028845174,-0.012260701,-0.015406619,-0.022560582,0.045190033,-0.012017307,0.009945677,-0.018577898,-0.0007060147,0.0183459,0.07296557,0.042996757,0.060272586,0.012577327,0.0376535,-0.04530783,-0.0107466215,0.04886155,0.051411763,0.04275914,-0.02215188,-0.05319557,-0.03699402,-1.3119952e-35,0.11129218,-0.012379861,0.044301998,0.1418366,-0.053803418,-0.021765476,-0.05617969,-0.03318348,0.040001594,-0.042160213,-0.09843849,-0.03309595,-0.020280166,0.014351252,-0.02626819,0.007569032,-0.09516938,-0.016674176,0.04046304,-0.07245267,0.016382294,0.0035196876,-0.042592302,-0.047950517,-0.01601345,0.12295034,0.08254768,-0.01947293,-0.0377294,-0.02139515,0.015389575,-0.011498003,-0.07409758,0.028967706,0.020404309,0.012589565,-0.04034701,0.00061670877,-0.039218817,-0.0065834536,0.016023712,-0.047797382,-0.04170489,-0.10761184,0.12164413,0.027300177,-0.06853405,0.001400855,0.03731333,0.081268355,0.038518954,0.0071197227,0.08628503,-0.007223372,-0.10266431,0.0007950326,0.02753879,-0.012241085,0.047336727,0.03609716,-0.01348814,-0.020631725,-0.063155234,0.0037774553,0.039431777,0.0027996923,-0.08272844,-0.038312607,0.03792192,-0.036865912,0.027406331,-0.05634349,0.101032935,0.029493816,0.08531852,0.004498753,-0.05764617,0.03617327,0.015766922,0.02666302,-0.010006655,-0.009922097,-0.029810634,0.03448814,-0.06542584,0.043932274,0.028583726,0.020700136,0.023002127,-0.049477458,0.019870339,-0.03236529,0.010451763,-0.022438852,0.00794401,-2.0923247e-33,0.08916858,-0.099216156,0.020630693,-0.0026606913,0.07837024,0.0041516605,-0.04272894,0.057468396,-0.031291313,0.09915163,0.055818096,0.01886901,-0.036863733,0.015234596,0.028882138,0.082833216,0.02786473,-0.026674956,0.004176131,-0.010637585,-0.012109191,-0.008786933,-0.027974969,0.042454418,0.1348833,0.020842139,0.13590832,-0.043863885,0.00071717304,0.07442222,-0.1017477,0.04337288,-0.0030369903,0.038932543,-0.020825123,0.040850073,-0.105152,-0.028192839,-0.08822018,-0.0072678137,-0.12679522,-0.006629381,0.019198475,-0.004332378,0.03684625,-0.026027257,-0.0039288015,-0.04983535,0.04995504,-0.0150203295,0.08567286,0.046046153,-0.015154741,0.015570835,0.0018824878,0.02574696,0.02014962,0.08643583,0.09569124,0.019216115,0.018037241,0.025899792,0.041777976,-0.046395887,0.015515546,0.090458386,-0.021632362,0.062124513,-0.054790303,-0.007916523,0.08609338,-0.061805714,0.12903278,-0.052517172,0.040747292,-0.08052769,0.031238867,0.011503554,-0.078807205,-0.019842219,-0.03787623,-0.09700607,-0.038912937,0.012651719,-0.06495306,-0.05733356,0.026918111,-0.0025241128,-0.0313559,0.01735074,-0.021355111,0.06715795,-0.071740985,-0.011298003,0.04953646,-2.485557e-08,0.001622068,-0.032688588,-0.048259836,0.034641568,0.02727023,0.015497137,0.0025803065,0.021890568,0.0027036334,0.009437362,0.10928993,0.035304908,0.020422239,0.058037158,0.013024594,-0.016632501,-0.08023866,0.02294687,-0.014412746,-0.018586474,-0.030992232,0.011443488,-0.023745697,-0.054164402,0.0039909007,-0.061617322,-0.024847938,-0.03939289,0.11254715,-0.035161734,0.033431035,0.10701105,-0.0056647514,-0.09097998,-0.063465565,0.078813285,0.010443456,-0.071372375,-0.018668564,0.038249608,-0.09968954,0.007966451,-0.015357427,-0.035365205,0.021927323,0.044884276,0.02430855,0.053031694,-0.008155255,-0.02055289,-0.031546947,-0.013828807,-0.0020881991,-0.036163736,-0.078131944,0.02540832,-0.028153539,-0.018617345,0.00808777,-0.022291465,-0.0026937407,0.036430556,0.1703664,-0.005319011 +2.3.1.171,"Acts on pelargonidin 3-O-glucoside in dahlia (Dahlia variabilis), delphinidin 3-O-glucoside, and on cyanidin 3-O-glucoside in transgenic petunia (Petunia hybrida).",384,1.0,-0.05716623,-0.04056751,-0.10562339,-0.05688643,-0.011651078,0.042313337,-0.022784935,0.025821524,0.078066,-0.014736819,0.07792933,0.013012414,-0.0973506,0.0066318098,-0.068258755,0.031976473,-0.024181817,0.13079888,-0.101354204,-0.0016934607,0.009143988,-0.02393679,0.07414342,0.05739579,-0.06592466,-0.00439456,0.033196572,-0.026291726,-0.033712786,-0.06836927,-0.108047,0.0254359,-0.011887594,-0.042240012,0.009127698,0.010654166,-0.057882387,-0.044830933,0.033927016,-0.048409987,0.034681957,-0.031200638,-0.020240987,-0.042277474,-0.08160626,-0.08364693,-0.03290268,0.003543814,0.04646121,0.009466766,-0.02079462,-0.014479149,-0.059026565,0.01649317,-0.031374764,-0.09799344,-0.06777667,0.013536163,-0.010235738,0.07244992,-0.0068400432,0.05832,-0.036503132,0.021286745,-0.048926238,-0.0447061,0.01690285,-0.03114515,-0.0471712,-0.023950508,0.03322843,-0.0067347325,0.080112204,-0.024705142,0.05065821,0.097366564,-0.042193033,0.023528444,-0.051604625,0.0062644416,0.011799121,0.034123562,0.016596368,0.087850206,0.050924666,0.025862724,-0.07090293,0.075352706,0.0006721756,0.059584703,0.048678752,0.03296611,0.008802244,0.07223923,0.035789147,0.045290336,0.009720472,-0.05443677,0.035695676,-0.023685135,-0.058882613,0.021640249,0.069641694,-0.046436105,-0.093216345,0.0023871802,0.046256717,-0.009605431,0.006148828,0.0037260442,-0.011968007,-0.022779502,-0.03286795,-0.051733296,-0.09579727,-0.01825157,-0.0026020922,-0.07176134,0.012512672,0.027517721,-0.04873326,-0.027326837,-0.046745334,0.04534982,-0.008062851,0.029117439,-0.026899194,3.053895e-33,0.056964725,0.03413973,0.0051682,0.04536613,0.029380415,0.025885899,0.0026270337,-0.06873963,-0.084257185,-0.024632262,-0.18326055,-0.006599364,0.02911744,0.0055923946,-0.01761192,0.021295585,0.002020708,-0.04093153,0.13023548,0.0018718205,0.12069122,0.04985261,-0.09974003,-0.039250385,-0.034976948,0.08607319,-0.015382112,-0.041037537,-0.04843128,-0.014909842,0.027624214,-0.06219836,-0.008931089,0.021957284,0.047047064,0.002750466,-0.041376088,-0.091094464,0.018611113,0.11906904,0.033367872,-0.048619077,-0.0031705126,0.021861503,0.03778615,-0.052616984,-0.0850705,0.064330965,0.0094860215,0.06923512,0.10068305,-0.026703244,0.01059786,0.046364125,-0.08054222,-0.044260986,-0.01819259,0.00068935205,0.07074074,0.017138518,0.0013743602,0.062234823,0.030893857,-0.0658038,0.013475991,-0.047295947,-0.16078594,0.0236626,-0.048428822,0.044525012,0.003183258,-0.069053285,-0.06661233,0.065679505,0.124588184,-0.015409787,0.009140288,0.1442524,0.05500567,0.038716942,0.028288137,0.08781854,0.038279332,0.053212922,-0.08876872,0.062281698,-0.008341701,0.011452161,-0.045442294,0.026620196,0.06832904,0.02101794,0.024411766,-0.0020071086,0.049272582,-3.8011384e-33,0.021621566,-0.048732366,0.07782064,-0.05797695,-0.054361638,0.018331997,-0.124854945,-0.008179418,-0.01328324,0.051340703,0.052334614,-0.010966998,0.08265838,-0.0067832526,-0.09085623,-0.022679996,-0.012106669,0.013343875,9.501772e-05,-0.053111535,-0.08470586,0.002924844,-0.0552338,-0.058718987,-0.004114887,-0.03393161,0.019899718,0.017762387,-0.057715353,0.03804621,0.05565827,-0.023746168,-0.069360845,0.06057125,0.036521327,0.024724688,0.023810701,-0.06853031,0.048626933,0.0003717686,-0.047770597,-0.04807923,0.03625422,0.03405424,0.07246114,0.052267138,0.024305569,-0.013958329,-0.05326745,0.059731983,0.027092509,0.035789676,0.04277964,-0.03968612,0.123765856,0.023176638,0.09404508,-0.09735544,0.012609206,-0.016726851,0.023455393,-0.016949665,-0.008813836,0.10666273,0.04022674,0.09029581,0.016876344,0.010052237,0.056535665,-0.007911298,0.0003169415,0.06136477,-0.012841369,-0.02633556,-0.0044674054,0.0068244766,0.024395155,-0.0050608288,0.0124983825,-0.0015852182,-0.0010823988,-0.100303724,-0.027787883,-0.111385524,0.010229483,-0.0027361666,0.04625357,0.055327635,-0.024756476,0.014340535,-0.005940498,0.0031394204,0.02435377,0.016050328,0.054214355,-3.061376e-08,0.014191175,-0.009423652,-0.06590642,-0.019254845,-0.015960637,-0.00058992585,-0.017966533,0.0048209266,-0.011765885,0.014801684,-0.004636606,0.0048021483,0.0056192493,-0.015200492,0.10055647,0.06246762,0.09636853,-0.029300516,0.0470294,0.044771,-0.06010433,0.06804729,-0.033928696,-0.014278856,-0.0152039975,-0.052559152,0.09510081,-0.015173911,0.00261363,-0.040985156,0.0040687886,0.02749286,-0.046547197,-0.075576425,-0.046331152,-0.024036253,0.043514866,0.0026251453,-0.027800322,-0.02412237,0.047383126,0.026169635,-0.07177789,-0.03815392,-0.010466119,-0.023206588,-0.004151517,0.0023119259,-0.032087058,0.027570227,0.04012111,0.04311016,0.073380165,-0.057436418,-0.10013799,-0.03376623,0.08268559,-0.007332535,0.036931995,-0.06910459,-0.09361958,-0.02731804,0.08622178,0.046720747 +2.3.1.172,"Specific for the penultimate step in salvianin biosynthesis. The enzyme also catalyses the malonylation of shisonin to malonylshisonin [cyanidin 3-O-(6''-O-p-coumaryl-beta-D-glucoside)-5-(6'''-O-malonyl-beta-D-glucoside)]. The compounds 4'''-demalonylsalvianin, salvianin, pelargonidin 3,5-diglucoside and delphinidin 3,5-diglucoside cannot act as substrates.",384,1.0,-0.09846777,-0.078836866,-0.087825686,-0.004033522,0.059881765,0.012080321,-0.056922715,0.0021612449,0.10093359,-0.033475865,0.03983237,-0.03511723,-0.08051001,0.0037290521,-0.034304906,0.022787696,-0.16181451,0.111190215,-0.023712937,0.017635843,0.11627516,-0.018406076,-0.05364384,0.006118954,0.04909996,0.016395582,0.06062997,-0.006519435,-0.0068718665,-0.049027774,0.018891314,-0.029341502,0.046618793,-0.05681507,0.013122996,0.12036856,-0.02284732,-0.07131227,0.008769035,-0.003503707,0.04649268,-0.03198058,-0.019051915,-0.000111120884,-0.01745307,-0.103750475,-0.03348183,0.0069464026,0.09241029,-0.06844631,-0.111282706,-0.033855513,-0.068868,-0.016412867,-0.00045615368,-0.08331042,-0.12686656,-0.043519963,-0.02124185,-0.01945148,0.021895314,0.009097578,-0.022033192,-0.03947813,-0.063333735,-0.049226332,0.022179293,-0.075183645,-0.004113359,-0.0067625754,-0.01593489,-0.056730792,0.02494504,-0.0061695287,0.01135383,0.110943764,0.025426686,0.0024783593,-0.059270695,-0.084647,0.03607457,0.050186206,0.06077749,0.12785704,0.016563147,0.031923182,0.025514444,-0.046442818,0.0168403,0.04559689,0.053928997,-0.040195186,0.0002234039,-0.108882315,0.036385152,0.040401038,-0.037101302,-0.009282487,-0.017027328,0.04809324,-0.021337401,0.04672177,-0.09647747,-0.12896132,-0.08327571,0.08116296,-0.027534408,0.032754146,0.025389854,-0.004376711,-0.00050698285,-0.0023573705,0.010313758,-0.050760522,-0.08116772,0.10142384,-0.02637144,-0.044998314,-0.003907868,0.06900511,-0.026965128,-0.010258805,0.021155318,0.049514446,-0.06533686,0.046431698,-0.021903293,3.2766358e-33,0.09491388,0.013866953,-0.0013942026,-0.033218086,-0.012643785,-0.024611868,-0.027832657,0.002575033,0.021562092,-0.043526657,-0.09949178,-0.062265243,-0.019786386,-0.042465776,-0.048552264,-0.04212958,0.040621053,-0.073901534,0.09276155,0.010987222,0.0047775474,0.06822307,-0.035580356,-0.049090628,0.004804904,0.08752211,0.0016111146,0.015108174,0.016208682,0.0135165155,-0.033059254,-0.022055004,-0.015831785,0.031384982,0.048191894,0.0677822,-0.025678135,-0.012973369,0.041278955,0.0143287,0.037072003,-0.024263874,-0.0123906545,-0.0062641106,0.018130466,-0.011955367,-0.0569641,0.06733242,0.023067063,0.02826914,0.0044948882,-0.015850378,0.08887616,0.024165273,-0.07326717,-0.07363593,-0.022807099,-0.057733692,0.0294563,0.066673204,0.039801516,0.009503918,0.013649076,-0.02477671,0.020635104,0.061217397,-0.055912815,0.041526414,-0.020906404,0.036842376,0.03139828,0.014014865,0.019661732,0.04893022,0.02143696,0.005364546,-0.007184493,0.06818716,0.064713754,0.010664624,-0.0036810695,0.028318282,-0.037838444,0.05669874,-0.060403828,0.047460455,-0.054799702,0.017114867,-0.008909639,0.0932473,0.013859353,-0.03221604,-0.0119641805,0.03209421,-0.064725436,-4.569263e-33,0.021349512,-0.08108006,0.0066554854,-0.08233688,-0.09748954,0.061737653,-0.018599851,0.02773621,-0.05457717,0.03177449,0.028351786,-0.04679048,0.0318073,-0.07429883,-0.0637763,0.044750933,0.035087135,0.07230925,-0.06260878,-0.014500804,-0.053476688,0.08128904,-0.038391765,0.06248626,0.10070149,0.001252395,0.009217294,0.033151347,-0.044839993,0.09167465,0.04151576,-0.04382027,-0.09486659,-0.04360837,-0.015002111,0.051109962,-0.009894281,-0.003957843,0.021775188,-0.011777057,0.006450923,-0.00057350646,0.0740473,0.120004,0.10759503,0.037756678,-0.05912035,0.013354053,-0.051931947,-0.026846185,0.02760834,0.0178266,0.03130374,0.0070138993,-0.02052329,0.0739501,0.065837294,-0.052162375,0.028759375,0.01653216,-0.067604415,-0.09128585,-0.06070207,0.03240973,0.08622476,0.071870446,-0.032729544,0.043444585,0.04407768,-0.05861504,0.0069480715,-0.05262578,0.06585717,0.03545005,-0.046976876,0.016116025,0.0028632537,-0.041434295,0.02040008,-0.001297977,-0.015034999,-0.079960935,-0.059038367,-0.05373583,-0.069649816,-0.002059194,0.14188862,0.023605175,0.004204413,-0.0038134337,-0.0026912661,0.03751238,-0.012445414,0.06670127,0.08433199,-4.3000497e-08,0.08634894,-0.12743329,0.036745045,0.0012594159,-0.040355854,0.0016432905,0.008247257,0.022996662,-0.0115065025,0.01940292,-0.025822368,0.073660955,0.0063555227,-0.01961978,0.04626834,0.053687878,0.06255512,0.121648595,0.017894844,-0.036063876,-0.040049784,0.026836123,-0.06730912,0.03646315,-0.008956709,-0.1506597,0.06359413,0.024801701,-0.014579267,-0.0018198643,0.058411293,0.017499954,-0.03458456,-0.0021881897,-0.06397446,0.00130776,-0.039725356,-0.079943195,0.042176638,-0.012550439,-0.0401214,0.04070714,-0.063762106,0.0066846632,-0.004651701,-0.0021200038,0.014163385,0.029250499,0.0042567323,0.0046861684,0.029730625,0.031847768,0.013371619,-0.068065725,-0.062429197,-0.035480473,0.035652395,-0.010775249,0.017901935,-0.021999188,-0.011204556,0.038079318,0.117903605,0.030584302 +2.3.1.173,"Acylates kaempferol 3-O-triglucoside on the terminal glucosyl unit, almost certainly at C-6.",384,0.99999994,-0.12505758,-0.09065821,-0.14904158,0.009583591,-0.036769968,0.046155326,-0.06335801,0.0070692166,0.0695172,-0.009482507,0.084305614,-0.065879956,-0.124083884,-0.017712643,-0.03427388,-0.003504163,-0.00021976035,0.01911796,-0.05145259,-0.04661176,-0.004669991,-0.0386081,0.052045137,0.0110561615,0.08961237,-0.0075580063,0.028942024,-0.027481323,0.02026525,-0.04675462,-0.09062779,0.012768331,-0.0020478168,0.0055452627,0.1035509,0.039043915,-0.098026335,-0.077963166,0.08601122,0.023077993,-0.01940346,-0.049057323,0.034586415,0.014532404,-0.037381567,-0.011372775,-0.0796802,0.08672112,0.0058870194,0.045314506,0.09404852,-0.02636166,-0.061823636,0.0008086768,-0.009569428,0.027155515,-0.10170157,0.011391949,0.016124625,0.13767639,0.023253536,0.0341472,-0.049205393,0.06609366,-0.08830283,-0.009860858,0.0827897,-0.051238928,0.010665689,0.027690593,-0.033833414,-0.056975994,0.05652906,-0.0066853017,0.06749903,0.00236423,0.017900761,-0.059916787,0.022988187,-0.0564101,0.12663707,0.08422285,0.08216422,0.0565616,-0.009348607,-0.06981136,-0.023530936,0.040300313,0.0017351343,-0.029656708,0.010846733,0.001548882,-0.04513595,-0.048734173,-0.010401974,0.06525636,0.037252847,0.018162344,0.00730468,-0.050758872,0.008970906,0.08101906,0.07310234,-0.0130335735,-0.04144506,0.05473877,-0.06096443,0.08358581,0.0035011931,0.028470365,-0.055386566,0.013852416,-0.009942992,-0.09257139,-0.02228198,0.058789458,0.04227838,-0.0509149,0.016674763,0.027947837,0.0017487612,-0.04940974,-0.01485848,0.045296982,-0.058519367,0.015216673,0.051050242,2.49787e-33,0.076493636,0.033065528,0.04964222,-0.000677593,-0.032735042,-0.023372073,-0.04995209,-0.090944454,-0.089871496,0.042890962,-0.0638714,-0.023208646,0.004239281,0.056293823,0.02218576,0.025604399,-0.04516925,-0.03235418,0.01226721,-0.023544444,0.051672634,0.103831455,-0.024924248,-0.0019546864,0.045187376,0.081318885,-0.034808222,0.04944269,-0.036103334,-0.028484285,0.0030524011,0.0069300304,-0.033490483,0.025697878,-0.026407545,0.016605236,-0.16622232,-0.055669557,-0.0049517066,0.061127696,0.06215157,0.04176733,0.014286221,-0.029725188,0.011593564,-0.03609148,-0.02341188,-0.013412222,0.010287313,0.06996447,0.030771388,0.034194604,0.023011953,0.0824809,-0.010069028,0.011452845,-0.028547144,0.017409146,0.060031503,-0.010487692,0.035708804,0.06897987,0.007920174,-0.0059455293,-0.053567186,-0.0036525447,-0.13924168,-0.04168976,-0.035438217,0.05660705,-0.03525191,-0.050047398,0.005385021,0.032665305,0.0579793,0.009666768,-0.0043407357,0.0402289,-0.050585773,-0.024704874,0.020851674,-0.023822716,0.09154282,0.06106538,-0.084759146,-0.04029186,-0.03603656,-0.012765186,0.00089686975,0.026769599,-0.019203335,-0.03368286,-0.025345411,0.06299104,0.004466285,-4.1039593e-33,0.12956476,-0.045675818,0.03700097,-0.074993566,-0.0910703,0.045721807,0.01197529,-0.104907535,-0.014921914,0.025452824,0.10787846,0.10725405,-0.01961005,-0.010196099,0.05497598,-0.021298643,-0.0076957354,0.014973836,0.008384279,0.03610608,0.021202365,-0.018296055,-0.0315949,0.019880578,0.044883218,-0.0070558796,0.06968512,-0.12124909,0.015352847,0.035255678,-0.030406201,-0.045839828,0.005235852,-0.028059863,0.024187425,-0.04676599,0.026782596,0.014788495,-0.088752724,0.054911196,0.0368113,0.08044588,0.01810747,0.055416442,0.06889221,0.026034951,0.004719072,-0.058382716,-0.06098618,-0.07757085,-0.01640004,-0.022356175,0.0043160054,-0.023406327,0.06392813,0.093912125,0.048774168,-0.10848102,0.04684855,-0.05816994,-0.07280462,-0.050562955,0.004077945,-0.08037605,0.06609985,0.07556486,-0.0030250838,0.07838656,0.0148255015,0.014684667,0.025090724,0.02102034,-0.01797538,0.0034078837,-0.013000659,-0.101032645,0.02274315,-0.00947804,0.029857665,-0.03256736,0.031153485,-0.098924376,0.0048732604,0.04706196,-0.017570447,-0.08694674,0.054306716,0.055336513,0.035380322,0.013608113,-0.015329849,0.032905728,-0.005277858,0.030669631,0.041621726,-2.585559e-08,0.06757106,0.038837414,-0.010925798,-0.043145124,-0.006348404,0.030122535,0.058470342,0.016960735,-0.064813256,-0.009558388,-0.016108042,0.08930591,0.05930548,-0.04197135,0.010531643,0.033216547,-0.10546775,-0.0126284165,0.022983624,0.03160759,-0.07031529,0.038019884,0.0017414493,-0.009316871,-0.014915383,-0.01390406,0.09679983,0.07882329,-0.0020199406,0.042160355,0.0042556627,-0.0039121103,-0.042252164,-0.025061408,0.046148982,0.0018094772,-0.01345484,-0.051769994,-0.08388629,0.015277639,-0.028778171,-0.012378825,0.010320229,0.042414993,0.02064129,0.013209902,0.014427118,-0.0039711716,-0.010807227,0.026175851,-0.054072008,-0.02907271,-0.09462577,-0.0035951298,-0.0804051,-0.09900406,-0.030051686,-0.044072255,0.00938614,-0.11307067,-0.03900839,-0.045259897,0.06747105,0.011204443 +2.3.1.174,"The enzyme from the bacterium Escherichia coli also has the activity of EC 2.3.1.223 (3-oxo-5,6-dehydrosuberyl-CoA thiolase).",384,1.0,-0.06828572,-0.060908906,-0.032575164,-0.006569035,0.088769704,-0.004941325,-0.096215114,0.049822018,0.06966343,-0.03289126,0.02368747,-0.09587427,-0.069908306,0.036509983,0.0072857128,-0.03554512,-0.03781284,0.022626672,-0.013208499,-0.085000046,0.056272276,0.057518627,-0.018655358,0.029814653,-0.0144807855,0.032802567,0.06846919,0.031082232,-0.048589993,-0.094456404,-0.012512789,-0.08313977,0.12316229,-0.05833373,0.03993294,0.05212935,-0.035701968,-0.14263356,0.047685917,0.028991573,0.039309666,-0.01918961,0.012183795,-0.03263236,0.02802709,-0.063164175,0.0063877497,0.03509935,0.048200127,-0.052155312,-0.0001885634,-0.0701307,-0.016147492,0.04059249,-0.025101155,0.0037255236,-0.02180765,-0.017525041,-0.021714937,0.012573633,0.04965262,0.050774552,0.053330816,0.027301611,-0.0065739946,-0.058068935,0.070918694,-0.06874565,-0.017730573,-0.014110642,-0.08091118,-0.050025456,0.03999484,0.055279538,0.0037841485,0.006610053,-0.0032597273,-0.08185177,0.05899828,-0.04198192,-0.022243356,-0.040399443,-0.037241388,0.059758414,-0.011480344,-0.0076533975,0.04638644,-0.03576314,0.0023189487,0.033038694,0.035786964,-0.060155492,-0.026193982,-0.029546876,-0.039089948,0.074056804,-0.015624829,0.07281191,0.05824704,-0.06021798,-0.018225979,0.13354477,-0.06527708,-0.030610984,0.03143659,-0.014549147,0.0384102,0.10582247,-0.0045032036,-0.0044210395,0.0022771945,-0.104597725,0.017002711,-0.010318019,0.0061730715,0.083919846,0.038965065,-0.05730088,-0.042074557,0.022162665,0.07067279,-0.070558816,0.038805217,0.06215785,-0.06524571,0.024665214,-0.08386289,1.3218425e-34,0.046790387,0.016480302,0.033844262,-0.021208605,0.0131934015,-0.014589007,-0.10022687,0.09002553,-0.048810195,-0.014396099,-0.054421622,0.013889284,0.107878804,-0.025854366,0.023093909,-0.049276162,-0.017860038,0.0037964897,0.01591233,0.012578032,0.043233857,-0.029442476,-0.022439925,0.052329276,0.039968513,0.048340775,0.0024073457,0.0032871347,0.1011541,0.019737512,-0.0022764981,-0.09138558,-0.06164315,0.0008829279,0.021908386,-0.059730384,-0.031658094,0.041245617,-0.02208056,0.049707998,0.05333646,0.05945098,0.005830885,-0.048173282,0.028094806,-0.05489488,-0.04840432,0.10714752,0.0911414,0.039803337,0.031761263,-0.06284864,0.0933472,-0.093406096,0.03253141,0.030387696,-0.029072214,0.06884182,0.029000428,0.049069434,0.009621508,0.12357815,-0.025417687,0.04294054,-0.05343291,0.0746122,-0.05961626,-0.043007106,-0.0006941773,0.05785866,-0.09813333,0.06411654,0.028963119,-0.015917158,0.035692163,-0.026738131,-0.083405,0.0058256383,0.023384651,0.00443697,-0.021189285,-0.05071209,0.036743056,0.010375319,-0.026528427,0.018511156,-0.051954426,0.06546188,0.033515267,0.09929196,0.086145535,-0.06580545,-0.034055807,0.014964724,0.0057500494,-8.171455e-34,0.07598084,-0.08143922,0.0075641377,-0.10649804,-0.05312289,0.06123346,-0.045101,0.034413878,0.05566653,0.0075530843,0.10437827,0.028707555,0.03551126,-0.069256395,0.04261825,0.004943329,-0.052233588,0.013457383,-0.044439703,0.007267359,0.026440298,-0.020436354,0.019056618,-0.036423247,0.052065305,0.052727822,-0.0046470063,0.00906163,0.020004844,0.016386446,-0.056304757,-0.038522825,-0.0131147215,-0.0061839162,-0.06732366,0.016275926,0.015817018,0.008723731,0.026919313,-0.023905788,-0.023228971,0.030714355,0.03596242,0.072508596,0.016629953,0.10976152,0.0055810646,0.013150742,0.0019879148,-0.031732224,-0.008622047,-0.09481779,-0.055609353,0.019123323,0.012938838,0.03183677,-0.024567725,0.0371444,-0.0029366955,-0.020671787,-0.01289982,-0.045118637,0.021726469,-0.021353945,0.018098217,0.004668984,-0.08930758,0.07312292,0.011964768,0.006481036,0.081548974,0.0019771531,-0.026769858,-0.07551242,-0.032175723,-0.028847763,-0.040848516,-0.027921699,0.0354002,-0.011845357,0.002064493,0.013950867,-0.05417582,-0.07232435,-0.02000792,-0.051704373,0.044176567,0.11720581,-0.016054776,0.046729326,-0.08874123,0.0012282091,-0.047937788,0.042262457,0.030816812,-2.9529003e-08,0.0048982487,-0.06952021,0.045109328,-0.025882151,0.10865222,0.071204364,0.0055792625,0.047142856,0.08954253,0.02785572,0.0029521447,0.07440708,0.058814913,-0.049521115,0.031922378,-0.03533271,0.0016582658,0.015435022,0.013916462,-0.019653343,0.0074063186,-0.040013455,-0.057015877,0.00021470635,0.026055306,-0.067080356,0.010563513,-0.052603822,-0.08913015,-0.040755127,-0.056260575,0.0237275,0.017208977,0.008867993,-0.049889658,-0.010566393,-0.064548135,-0.027534945,-0.11196499,0.05342061,0.062309187,-0.046924967,-0.109372064,0.0066380072,0.039740205,0.03891279,0.03712743,0.010136533,-0.03880379,-0.075732596,-0.00760918,-0.075892255,0.010457309,0.014066018,-0.09914162,0.0030928147,0.010016546,-0.14176467,-0.04224174,0.0015321171,0.042090017,0.014489056,0.19377962,0.042556595 +2.3.1.175,This enzyme catalyses the final step in the biosynthesis of cephalosporin C.,384,0.99999994,-0.04921724,0.031350035,-0.09659061,-0.03726685,0.061801203,0.038729176,-0.10718292,0.035418816,0.05505199,-0.0012990666,0.022205591,-0.1377148,-0.02201976,0.0013411891,-0.06345568,-0.047762282,-0.118110195,0.017226601,-0.036277205,-0.08638293,0.054746155,-0.05369459,-0.033527512,0.012191516,0.027425565,-0.015854059,0.02656406,-0.056200523,0.0150512215,-0.06262104,0.023684705,-0.054631848,0.023722958,-0.042738277,0.06508699,0.07718111,-0.013590769,-0.069186844,0.07964787,-0.048293434,0.028397668,-0.016534733,0.0030549918,0.01267927,0.0067892014,0.046990693,-0.028557789,0.009372956,0.034287196,-0.03468548,-0.042462658,-0.055771753,-0.046477538,0.029085271,0.0080905715,0.020014284,-0.0047342563,-0.004829009,-0.022945113,-0.017476214,0.058470566,-0.03455281,-0.04864832,0.036005262,0.02653096,-0.0743863,0.0141366,-0.07901337,0.010266025,-0.009712421,-0.13277854,-0.06705799,0.04254788,0.11303188,0.0047530998,0.041885186,0.01054875,-0.037412222,-0.0043928935,-0.016861677,0.087845184,0.04043461,0.0024507388,0.060081102,0.04535661,-0.017840208,0.047785297,-0.018905036,0.0564971,0.064974286,0.010066071,-0.007939651,-0.065272376,-0.010130697,-0.05043617,0.10691376,0.057862893,0.0004394121,0.050811578,-0.06297973,-0.024000205,0.08084946,0.07565507,-0.093779564,-0.006726654,0.00048238976,-0.009160427,0.12852015,0.047232628,-0.015265372,0.030873055,-0.05980889,0.04303074,0.0007374499,-0.024165938,0.1653391,-0.005065762,-0.0131256925,-0.010725665,-0.007241252,0.061563324,-0.011534881,-0.0144646,0.050210185,-0.10610891,-0.028441058,-0.047314744,-6.3497206e-34,0.048677027,0.02622519,-0.058566935,0.0039169416,0.028408566,-0.017684164,-0.039009884,0.04163766,-0.086169094,-0.028438032,-0.019201001,-0.13597539,0.00273899,0.015787095,-0.06113373,-0.07785055,0.044457924,-0.021045826,-0.0120850485,-0.041814636,0.04530602,0.055826727,-0.028552407,-0.03496068,0.091257,0.06913029,-0.059668016,0.055957895,0.007722646,-0.009435795,0.009016848,-0.01114989,-0.08680888,0.049305044,0.08845701,0.009246145,0.013353933,-0.06095492,0.043440457,0.061665732,0.01999468,0.0040160855,0.007273358,-0.05329691,0.01903125,-0.042095564,-0.059525497,-0.009402834,0.08699887,0.043267295,0.104927585,-0.051526956,0.05925428,0.01387992,-0.030695572,0.04711618,-0.066479936,-0.09070953,-0.0019365294,-0.018568909,-0.020317793,0.044061616,-0.07840951,0.0071758344,0.0567303,-0.058261998,-0.024564566,0.022315525,-0.044620622,0.05118872,-0.058047872,-0.02917917,0.027602749,0.023754852,0.038468864,0.025509816,-0.017750295,-0.0032395837,0.011314223,-0.047325592,0.02175366,0.05147209,-0.053947676,-0.016231028,0.02275381,0.05606144,-0.066284835,0.0050844657,-0.041414022,0.01568411,-0.030395309,-0.050205268,-0.014417166,0.06403208,-0.0875234,-9.015487e-34,0.14759527,-0.079378396,0.01657215,-0.07863875,-0.06396731,0.057846602,-0.016358793,-0.07974868,0.018861663,0.0335104,0.032584373,-0.06499988,0.025670514,-0.018690405,-0.035001356,0.043552954,0.025551718,0.07242838,-0.04506953,0.035198566,0.030750912,0.07798772,-0.07109207,-0.004276831,0.08623251,-0.012488981,0.022201322,0.12524152,0.02013547,0.06915938,-0.03949589,-0.093700446,-0.047305334,-0.03059876,-0.056178946,0.035694513,-0.041614026,0.029733373,0.09871507,0.027412966,0.03134312,0.024870256,-0.024013167,0.027505834,0.13158986,0.0337165,0.0002493647,0.031862374,-0.004163871,-0.0006473092,0.058305692,0.0020416891,0.019321518,0.029370556,-0.03439959,0.03808346,0.074302115,-0.003528516,0.06282031,-0.09308175,-0.030783206,-0.032556262,0.057167422,-0.0037619926,0.059272762,0.09695548,-0.10172326,0.08278831,0.04167107,-0.052823983,0.06441863,-0.03061344,-0.027637297,-0.004800212,-0.0056289546,-0.03652005,-0.05782324,-0.050397545,0.03457757,-0.024596917,-0.017895088,0.046662312,0.09277111,-0.1428708,-0.016590275,0.0024210834,-0.0059713777,0.023213882,0.037891835,0.012440356,-0.037950523,0.01695632,0.033862706,0.042248104,0.06878263,-2.1737659e-08,0.023885656,-0.016998975,0.022856558,-0.027316775,0.03590868,0.035129774,0.050560206,-0.059568178,0.023535194,-0.06415001,-0.037108548,0.055936355,0.031490926,0.033171874,-0.014496691,0.023106596,-0.05739459,-0.005298645,0.006816799,0.026700744,-0.010743615,-0.021761352,-0.07799189,0.07039775,0.025972642,-0.02886852,0.019406771,0.06003901,-0.022038385,-0.0034275628,-0.06017398,0.059331708,0.01947315,-0.03840199,-0.044886425,0.012572534,-0.009093708,-0.08769693,-0.011693552,0.0014514753,0.043223683,-0.009306889,0.005323092,-0.003934944,-0.037101857,0.011237654,0.05612713,0.0045318175,-0.0050541554,0.008556523,0.060055643,-0.0701639,-0.047334205,-0.0033438914,-0.07174544,-0.024787357,-0.019649459,0.017528092,-0.04540315,-0.045021452,-0.0165981,0.007921185,0.19903241,-0.035428777 +2.3.1.176,"Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [3].",384,1.0,-0.024679534,-0.08700775,-0.07818171,-0.05789327,0.07617382,0.04755388,-0.07869421,0.022671167,0.024489632,-0.009258778,0.051996745,-0.012616219,-0.051443513,-0.01303527,-0.018916799,0.062482808,-0.04607223,0.008504696,-0.02512283,-0.09622922,-0.024716493,-0.029817497,-0.03534644,0.0027911698,0.036592204,-0.004248793,0.10110114,-0.05769545,-0.014365709,-0.045509636,-0.010829046,-0.056360546,0.03290237,-0.06469429,-0.1087511,0.030102149,-0.03213833,-0.011342496,0.059168056,0.01810233,0.075686425,-0.014775789,-0.028931437,-0.05948796,-0.0072398973,-0.074745804,0.057246234,0.01592801,0.052618027,0.06643635,-0.044191696,-0.012801956,-0.03127286,0.006564803,-0.02463048,0.11065909,-0.089861594,-0.105629385,0.032266073,0.0007986744,-0.018982418,-0.0195179,0.025255553,-0.022918686,0.0126135,-0.047782935,0.056211453,-0.038048238,0.07340845,-0.053832512,-0.05642688,-0.060109504,0.00010800918,-0.0147372205,-0.0097988555,-0.0026327597,-0.07013243,0.009892323,0.065186955,-0.059960302,-0.06318823,-0.026750237,0.033734735,0.06732431,0.06937155,0.020222386,0.020546071,0.0012880722,-0.0044671046,-0.018295292,-0.0056219557,-0.014486886,-0.012498123,-0.040088423,-0.042921763,0.02280914,0.028954994,0.010296636,0.0332876,0.005253908,0.030112673,0.08916476,-0.0466702,-0.11592152,-0.09364436,0.012289248,-0.01405772,0.07978311,0.0029473824,-0.00589839,-0.007595202,-0.014130737,0.07812477,-0.022648456,-0.03338794,0.16210161,-0.08283426,-0.07704408,-0.012522137,0.07228145,0.014236978,0.024338279,0.019890664,0.079323836,-0.0072802925,0.07467466,-0.011464717,2.4032756e-33,0.049864937,0.09139342,0.03195761,0.0187079,0.055217415,-0.02819082,-0.083909385,0.027720222,0.039627433,-0.031519692,0.04284894,0.0013751991,0.019327097,-0.026597345,-0.008283063,-0.028778154,0.03347231,0.003695866,0.06382953,0.038930453,0.010515001,0.06609965,-0.008394676,-0.03823534,0.029290471,0.030100431,-0.021509249,0.05143831,0.02535212,0.047003243,-0.023997644,-0.044992343,-0.048479218,0.023648985,0.018663967,0.009193339,-0.08273967,-0.022472136,0.019372925,0.118809074,0.12953737,-0.07210065,-0.046095435,0.020022327,0.032490775,0.0024137197,-0.018549249,0.042865448,0.052989468,0.056305043,0.028255828,-0.052618355,0.06771852,-0.043360364,0.0064339363,-0.031282872,-0.046482913,-0.04136856,0.014344001,0.05063784,-0.0005963317,0.07562237,-0.06264734,0.039374884,-0.026367538,-0.02361584,-0.07917442,-0.025317328,-0.05756479,-0.020658996,-0.019953297,0.017134698,0.047249272,0.057958413,0.017585512,0.0027750514,-0.06778177,0.018781926,0.041665733,-0.035399288,-0.03740935,0.06366974,-0.01557968,-0.087350786,-0.007349472,0.018699726,-0.0125748115,-0.115713224,-0.034275573,0.015252043,-0.008774859,-0.021389564,-0.030542742,0.011676418,0.077862665,-3.933324e-33,0.06156479,-0.1399594,-0.0041564475,-0.08050987,-0.07599782,0.038165566,0.038343765,-0.061825294,0.08116661,-0.01374039,0.040918928,0.004418942,0.000926301,-0.057707306,0.061786853,0.0010472242,0.090052195,0.053257946,-0.02159136,-0.10057883,0.013034572,0.021514244,0.044525165,0.07461285,0.014188048,0.04416264,0.03544197,0.018529747,0.10940151,0.12344143,-0.024584526,0.0017036845,-0.02818527,0.009412251,-0.039445467,0.02900853,-0.015545923,0.023414582,-0.014100804,-0.011422765,-0.016964257,0.023638867,0.076019645,0.0069141835,0.0056285015,0.03135899,-0.023845058,-0.004660913,-0.014660976,-0.10832831,0.08267856,-0.04559059,-0.036693256,-0.003624891,0.00046189505,0.1643063,-0.0053003933,-0.047262922,0.04647689,-0.11888452,-0.074760586,0.0082788095,0.010019002,-0.043435823,0.012778666,-0.004828448,-0.037672017,0.0070597297,-0.005952352,0.03829976,0.002596189,0.025521312,0.034833614,0.07006734,-0.0049473965,0.017199889,-0.0021300782,-0.04551663,-0.032896202,-0.10641323,-0.028151905,-0.05583821,0.004417177,-0.06636245,-0.050012287,-0.08431231,-0.03466984,0.10362007,0.06270898,0.023049183,-0.024917126,-0.006668033,-0.03338561,0.019198468,0.038837165,-4.1495706e-08,0.036699824,-0.09832551,0.003255902,0.01523046,0.010410228,0.07113251,-0.034273468,-0.06768312,0.06747745,-0.0603718,-0.10048602,0.15142193,0.06701905,0.005847718,-0.033418182,0.06699047,0.018216629,0.031949203,-0.0024471113,-0.06436155,-0.11611166,-0.002022639,-0.00027670298,0.0040370477,-0.008877234,-0.03807318,0.06747483,0.0027866163,-0.0199679,-0.03005015,0.01723299,-0.010290764,-0.031750616,0.0111080455,0.024981085,-0.014452415,0.06569472,-0.019009884,0.012069838,0.027331123,0.04146546,0.0056419945,-0.0828619,0.022013633,0.05810822,-0.04199325,-0.04036344,0.040274307,-0.036655527,-0.00082874903,-0.05552367,-0.010409569,-0.0010497278,-0.043749515,-0.030705044,-0.051011596,-0.007949447,-0.11831468,-0.013588158,-0.01660188,-0.0037066746,0.050121598,0.20686272,-0.027259322 +2.3.2.1,"The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a gamma linkage, forming gamma-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain.",384,0.99999994,-0.0430517,-0.075594604,-0.025292944,-0.020021714,0.06858261,0.042366534,0.042713754,0.067687005,0.045960642,0.027017165,0.04517309,0.0099836,-0.029876892,0.009971784,-0.014683065,0.056086715,-0.08639406,8.38835e-06,-0.04811728,-0.05869944,0.098537296,-0.005491533,-0.05445587,-0.033075828,0.052815195,0.03720831,0.041745752,-0.060961943,0.048944306,-0.016850566,-0.028776933,-0.055541527,-0.0417064,0.022240283,0.009102314,0.06368624,-0.04258392,-0.031182185,0.03993126,-0.033014115,0.04033175,0.054803826,-0.011312473,-0.062076308,-0.07114367,-0.011631802,-0.030808905,0.049519353,-0.017018186,-0.018159654,0.035880078,-0.0669579,-0.045284,-0.015714323,-0.0042171394,0.061554424,-0.046684183,-0.055420388,-0.0077054705,0.026752621,-0.03324727,0.05390823,-0.028654648,-0.010255233,0.08585433,-0.13133003,0.051399563,-0.048999302,0.021149093,-0.05870899,-0.06978887,-0.059375547,-0.054280095,-0.04931922,0.048548177,-0.10582587,-0.014227244,0.048787013,0.029591706,-0.031746436,0.07370833,-0.009602935,0.029413454,0.07731601,0.023020199,0.028037319,-0.003542769,0.05529931,0.11940501,0.0019364549,0.051093243,-0.0725233,-0.032480635,-0.0041948827,-0.050509118,-0.016383957,-0.023411825,0.033259243,0.04016838,0.039223358,0.0019623435,0.06851977,-0.052637547,-0.07027205,-0.025297685,0.021907376,-0.006178277,0.073254876,0.022843907,-0.06907097,0.020840878,0.03607483,0.077057764,0.07393049,-0.051085304,0.06341975,0.059029352,-0.03424913,-0.047315948,-0.05256142,0.05022242,-0.043522242,0.025900774,0.06433743,-0.08227077,0.044486865,-0.09824359,1.5044144e-33,0.047111027,0.019011611,-0.0004206931,-0.054902066,0.0045174146,0.0037915173,-0.061731063,0.0034057721,0.022326391,0.015019673,-0.12104834,-0.097256124,0.018114125,0.048847385,-0.02203431,-0.022407522,-0.019864874,0.04097786,0.07702379,-0.0029601075,-0.0011060397,0.07833364,0.013704235,0.071897514,0.06409326,0.09410799,-0.020100478,0.03830368,0.015033063,-0.0059153084,-0.04356479,-0.061566893,-0.0909635,0.07660164,0.018988375,0.017007424,-0.0010714373,-0.10388873,0.06315639,0.05087822,-0.042305194,-0.009752463,-0.031210024,-0.04793241,0.019044714,-0.0037954918,-0.011958521,0.09089543,-0.0019978513,0.08016572,0.034285747,-0.026046181,0.07125708,-0.052986264,-0.093929306,0.04791861,-0.02090023,-0.095278315,0.044090338,0.08251773,0.002207783,0.03168937,-0.027281696,0.0008519995,0.049409717,0.0186871,-0.016226571,-0.05376965,0.048445005,0.076329775,-0.093662985,0.00043450907,0.049011193,0.027781226,0.028491696,-0.09232865,-0.09894847,-0.01350184,0.047477677,0.013103329,-0.059882555,0.039619084,-0.020671725,-0.023551265,-0.016182423,-0.022003403,-0.036285162,-0.12080594,-0.022095501,0.002258818,-0.029423978,-0.0014370959,-0.01731075,0.025060238,0.062000763,-3.4713733e-33,0.04837976,-0.08549566,-0.042067226,-0.047028475,-0.060257502,-0.025716785,0.027116124,-0.038086556,0.0415653,-0.018872077,-0.029807085,0.0130905565,-0.04109143,-0.005431727,-0.008027626,-0.024489734,-0.035308808,0.08860691,-0.04335159,-0.039465636,0.0384325,0.017024467,0.04437407,0.02803949,0.075658485,-0.006706811,0.021926928,0.029264564,0.077876955,0.037548788,0.01410422,-0.027531682,0.034860928,-0.028510462,0.015723456,0.08595747,-0.0116058355,0.018117065,0.021903267,0.026286272,0.0024834175,0.059062347,0.092910506,0.040856685,0.031520616,0.054507222,-0.07422851,-0.009111515,-0.022727545,-0.12687437,0.07167429,-0.008563222,0.022163622,-0.0429683,-0.012745407,0.03561175,0.052887317,-0.031831708,-0.041163202,-0.012917132,-0.056435637,-0.06546828,-0.0036991048,-0.011655587,0.026238471,0.014918481,0.03997553,-0.016757643,0.01378468,-0.033311065,0.058236033,-0.044571023,0.030717565,0.051013775,-0.01091445,-0.08294546,-0.07480672,-0.026241908,0.074591786,-0.07512645,0.008833698,-0.03461888,0.01843803,-0.03713783,-0.05068539,-0.09450478,0.023521895,0.15554927,0.018533971,0.010333746,-0.055665288,0.031083832,0.03379526,0.06614813,0.092580885,-3.72428e-08,0.028260566,-0.067782715,-0.025836643,-0.014059906,0.013038871,0.09655215,-0.055670287,-0.009302192,-9.64322e-05,-0.034699872,-0.033638168,0.12666236,-0.054242685,0.016897043,0.007155198,0.0800896,-0.053454585,0.004863827,-0.042716432,-0.0246373,-0.08145086,0.013203656,-0.07480413,0.0069199465,0.017877396,-0.078107916,0.011160952,0.13472672,-0.020821907,0.026000528,-0.0073687783,0.060735177,-0.053319406,-0.058736075,-0.010512147,0.020116221,-0.025744576,-0.08045466,0.099435195,-0.0035692488,-0.005226786,0.03361631,-0.03799527,0.0055992343,-0.012427924,0.022705587,-0.03402822,-0.02719224,-0.055568296,0.09071084,0.08516927,-0.028114188,-0.0133945765,-0.021907032,-0.09838076,-0.037672725,-0.059534345,-0.08893299,0.021291872,-0.06375899,0.039170925,0.08086075,0.15842919,-0.00058336987 +2.3.2.2,"The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4].",384,0.99999994,-0.026992757,-0.044558074,-0.07055144,0.0065462305,0.09779679,0.041542582,-0.07882459,0.064857066,-0.008035108,0.008010458,0.035960414,-0.026465548,-0.016412282,-0.01895046,-0.06524802,0.06270946,-0.059785124,-0.016866537,-0.0016167071,-0.05547964,0.093767166,0.023982184,-0.037725825,0.01526069,0.04935776,-0.049402844,0.012599287,-0.0014708976,-0.06886789,-0.04422096,-0.03406895,-0.09476249,0.055888887,0.037768137,0.038881008,0.1026283,-0.0654233,-0.032883894,-0.0023767715,-0.034171782,0.059683066,-0.023459189,0.031062147,-0.07545304,0.03718829,0.0010730071,-0.006242912,0.00036054853,0.026536988,0.071988985,-0.04510428,-0.074226655,-0.004363072,0.056716118,0.019575574,-0.022923343,-0.0095080035,0.0099368505,0.013063699,0.04311932,0.029079163,-0.035278924,-0.0033229247,-0.05868072,0.044169743,-0.1333227,-0.035322525,-0.013932786,-0.04909083,-0.013948266,0.0022684433,-0.061117455,0.036343984,-0.03166037,-0.023610255,0.038989123,-0.04647866,-0.07436688,0.06798511,0.07947234,0.09867476,0.00045577908,0.06683484,0.105132714,0.06881168,-0.029696247,-0.03968651,0.018557688,0.02231934,0.0059599658,-0.004309518,0.0034562275,-0.053413678,0.06859128,-0.042780265,0.044304285,-0.0580326,0.014074072,-0.078509316,-0.03262064,0.00997208,0.01565479,0.014567171,-0.08652475,-0.019171748,0.02254168,0.02346059,0.08356095,0.038851876,-0.023624059,0.0036559042,-0.015228923,-0.037505955,0.0045735515,0.005606212,0.07736266,0.081383556,-0.06677183,-0.03352424,-0.044602778,0.023252256,0.0066628666,0.109729886,0.0008402002,-0.013720963,0.04609904,-0.03276274,2.6897838e-33,0.056982625,0.011962124,0.04311289,-0.040690374,0.05759065,-0.0124693,-0.07645261,-0.05587869,0.0132627925,-0.07279086,-0.06453983,-0.04171762,-0.021917375,-0.028392527,-0.039082155,-0.07266153,-0.033730436,-0.04068988,0.077068344,-0.0034641265,0.017347185,-0.090014435,-0.06969986,0.024531761,0.0027643805,0.05471663,0.02814881,-0.023959558,0.00955398,0.026783187,-0.03533949,-0.03643588,-0.08854107,0.005663514,0.0072768745,-0.037027385,-0.05581653,-0.06368197,0.017077116,-0.0015811255,-0.04684388,-0.014075078,0.054728817,-0.083962165,0.03825524,-0.07859888,-0.08229184,0.09005416,0.050383564,0.10350341,0.06615771,-0.103525005,0.09398658,0.023143211,-0.07368402,0.038333118,-0.085105434,-0.010659856,0.035339057,0.05700572,-0.0005530394,0.018322654,-0.018494,0.06681191,-0.027253598,0.019184362,-0.0983887,0.019306565,0.0033394159,0.10298645,-0.006354345,-0.039268818,0.096298,0.011332566,-0.052858528,0.007604528,-0.062286273,0.1220865,-0.018752763,0.029773237,0.041545454,0.03453104,-0.023467112,0.0035974379,-0.041294888,0.060067594,0.045409672,-0.06731653,0.08588873,0.006174282,0.061927367,-0.056849625,-0.020579249,0.064052224,-0.09163057,-3.1587745e-33,0.11517438,-0.08172367,0.061304186,-0.085828304,-0.021012325,0.015261769,-0.0091807,0.008694333,0.028253073,-0.046085734,0.017505696,-0.02888474,-0.052570123,-0.06295416,0.07728808,-0.064288974,-0.032679845,0.052720703,-0.0019517967,-0.030940095,0.05472283,0.042826794,0.00058077544,0.033660818,0.03460864,-0.03325504,-0.025517175,0.029325143,0.069296956,0.09288474,-0.013705559,0.06352866,-0.046899408,-0.008143572,0.0121481335,0.016762171,-0.042149134,0.03387071,0.11805348,0.033429477,0.04986074,0.0241312,-0.0075217965,0.041507963,0.054453544,0.14838883,-0.011041725,0.035556946,-0.024480863,-0.11015187,-0.03672507,-0.049571108,0.0036488734,0.016435273,0.008805622,0.030834919,0.007176174,-0.0042383494,-0.01949616,-0.036788665,-0.0063541285,-0.07153206,-0.048223015,-0.04735696,0.008270933,0.0509024,-0.009007096,0.026226262,0.04996372,0.0888494,0.027675968,-0.0022658226,0.0015792118,0.04216798,-0.03142751,-0.025970869,-0.113797605,0.0066220756,0.0126701435,-0.017594552,-0.0014315986,0.05966208,-0.035799563,-0.08120065,0.037294194,-0.11718581,0.018315641,0.1248904,-0.02936722,0.022797527,-0.083413914,-0.015631454,-0.0847415,0.04228225,-0.035933487,-4.5650268e-08,0.06917276,-0.027090274,0.031486697,-0.07790207,-0.011122218,0.030532196,-0.008793199,0.057120014,0.12543184,-0.0279874,0.03942075,0.078067325,0.023100005,-0.04910456,-0.057523355,0.016407471,0.07013683,0.028648607,0.0057332874,0.028219314,-0.0870363,-0.02855494,-0.07062003,0.014513743,-0.056233443,0.031110104,0.008992521,0.07130197,-0.056558933,0.0035590238,0.018448472,0.043305926,0.016804928,-0.011966595,-0.10842462,0.0727848,0.014754479,-0.01726324,0.012402509,-0.04620322,-0.01759364,-0.029123018,-0.011701,0.012803264,-0.03540958,0.015975878,0.014829652,-0.03429583,-0.013551391,0.04795665,-0.009695586,-0.0146259265,-0.005463037,-0.013874623,-0.07375829,0.003372,0.024036197,-0.04424251,0.0034118162,-0.070319645,0.034044437,0.013661723,0.17888404,0.00867182 +2.3.2.4,"The enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine.",384,1.0,0.0047658207,-0.121237665,-0.0038578976,-0.05732891,0.020638628,0.08481849,-0.043077204,0.04472072,0.028219536,0.0444222,0.060942255,-0.01806723,-0.021266429,0.079302005,0.014735105,0.0124905035,-0.07653794,-0.036735244,-0.07806876,-0.035954796,0.050147478,0.054267727,-0.068762206,-0.047782812,0.087521456,0.054249845,0.06197303,-0.0359809,0.035571918,-0.05187218,-0.017775258,-0.06595804,0.013041148,-0.0434114,-0.020972634,0.029092938,-0.1203289,-0.07569408,0.08371347,0.0032733993,0.036805704,0.042427935,-0.025769332,-0.11078734,-0.066217355,-0.041347727,0.07745699,-0.0357838,0.01130511,0.073116265,0.0374712,-0.09525201,-0.0294232,-0.0040885094,0.016793437,0.020249363,-0.08815209,0.038669303,0.014473013,0.06187388,-0.018501708,0.04832398,0.00029528188,-0.012962276,0.010282679,-0.04621098,0.0633375,-0.04808384,0.05161778,-0.06572718,-0.051104605,-0.09068607,0.01934689,-0.0339643,0.023182442,-0.05265099,0.02156707,0.036810733,0.0137896305,-0.07709205,0.036007524,-0.065481715,0.044782326,0.0357708,-0.015962286,0.042105805,-0.003490243,0.039740067,0.07304844,0.0035677021,0.056237523,-0.059796575,-0.039990027,-0.056446835,-0.015516046,-0.007377292,-0.031023817,0.006463872,-0.02375037,0.008054741,0.020638492,0.08000342,-0.040714398,-0.031626295,-0.018524174,0.008456051,0.013214753,0.013582335,-0.021429146,-0.06158212,0.0018885218,0.040208235,0.07314109,0.028464152,-0.07577587,0.03817956,0.040838715,-0.05520329,-0.05010369,0.0047348365,0.074095994,-0.0034799445,0.08069719,0.053742554,-0.035901245,0.0694001,-0.06221767,-1.1315409e-33,0.04582835,-0.033146553,-0.0041868244,-0.040216155,0.09040219,-0.05591564,-0.063217774,0.044666767,0.04690271,-0.009568775,-0.09312659,-0.022048391,-0.00767235,-0.03045077,0.020289095,0.037915807,0.0091008935,-0.02995947,0.034821242,0.01947766,0.018484153,0.035909973,-0.008534554,0.08045862,-0.013045657,-0.0022649781,0.07791011,0.06386839,0.039028388,-0.004051594,-0.06266868,-0.12034879,-0.10066941,0.0030335744,0.02857612,-0.00068308314,-0.050770856,-0.049095344,0.093674555,0.025028616,0.029735502,-0.008408124,-0.029602395,0.041690715,0.019333474,0.027694335,-0.033981565,0.08049236,-0.007951366,0.027535906,0.06201608,-0.07909906,0.035365738,-0.0165845,-0.0809694,0.05351829,-0.06740585,-0.002388942,0.036798276,0.061175346,0.0024306446,0.039238907,0.006868693,-0.001305102,0.011398034,0.03186889,-0.031084063,-0.07969971,-0.0027586292,0.048441447,-0.035127066,-0.063177206,0.09074819,0.026690928,0.015252922,-0.0737028,-0.06655376,-0.004647092,0.054602474,-0.009271056,-0.010266505,0.035143994,6.174195e-05,0.007902216,-0.0575076,-0.08711774,0.01595585,-0.101723135,-0.01808017,-0.012362159,0.002450176,0.019148408,-0.003732525,0.0038632064,0.025367599,-9.019494e-34,0.054841828,-0.09179196,-0.0019730122,-0.0103020575,-0.074637294,0.021550551,0.016098008,-0.034010053,0.017184244,-0.019044133,0.011760946,0.07190536,-0.033943247,-0.05594396,0.032843534,-0.0011174963,-0.012040781,0.021789199,-0.041324284,-0.04324768,-0.016363263,0.030722182,0.030456325,0.01742789,0.06690228,-0.0025010572,0.010718061,0.060371377,0.03167202,0.10299265,-0.020879176,-0.017442893,-0.025739983,-0.07252993,-0.051065132,0.07314073,0.046150945,-0.0082811415,-0.04445536,0.0150192315,0.012996356,0.06656391,0.076382235,0.061596904,0.03052337,0.046560675,-0.045239415,-0.04976174,-0.08397338,-0.085915826,0.02375998,-0.021357534,0.019556431,-0.028559124,-0.03231863,0.075556256,0.03899374,-0.045651156,-0.006802491,0.016707897,-0.03916624,-0.081639536,0.023835247,0.018210072,-0.021176036,0.02349764,0.054986104,0.0029391255,0.06675532,-0.011393988,0.079246126,-0.06325114,0.08586057,0.067172,-0.037191253,-0.008862271,-0.05687377,-0.061335918,0.030829256,-0.11623753,0.05783163,0.003928491,-0.021889746,-0.049170565,-0.033543468,-0.12541401,0.009336697,0.21526521,0.06273153,0.028781626,-0.02679611,-0.03892331,-0.024217268,0.055470712,0.069253035,-2.9965822e-08,-0.011840129,-0.070867814,0.026724732,0.0042036534,0.012644414,0.08094977,-0.051371418,-0.02080879,0.041513897,-0.043098364,-0.037994716,0.06424355,-0.09038662,0.018873213,-0.025432197,0.11965658,-0.046884306,0.11160772,-0.055764258,0.056081023,-0.09398152,0.056457054,-0.09914385,-0.019629383,0.06293641,-0.03880398,-0.02969351,0.09912964,-0.019754188,0.024762962,0.019526808,0.05151413,0.039233368,-0.064050436,-0.08641602,-0.0020373478,0.033147994,-0.013722623,-0.007801411,0.02147716,-0.017781578,-0.0073896353,-0.023526916,0.02231079,-0.013677012,-0.00022312776,0.003366903,0.015505328,-0.020697612,-0.005551064,0.07727008,0.004933408,-0.020312088,-0.018159676,-0.08918946,-0.039173227,-0.08108414,-0.0834465,0.020053163,-0.087734655,-0.03797012,0.07278375,0.14878501,-0.0061959904 +2.3.2.5,Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.,384,1.0,-0.02780611,-0.060153417,-0.07610395,-0.05297649,0.05641152,0.07994763,-0.036167618,0.00094236614,0.059695505,0.021450307,0.061638214,0.0060231225,-0.0900201,-0.034576803,0.031735398,-0.0018374759,-0.13933815,-0.010268928,0.017915545,-0.13465045,-0.025091367,0.057157088,-0.023897855,-0.024030134,-0.039331097,-0.042710382,0.04804419,-0.042054057,0.03269643,-0.03035713,-0.045923203,-0.029677486,-0.047102746,-0.05488797,-0.021024752,0.10007136,-0.11141582,-0.022283927,0.08018077,-0.037322674,0.11428929,-0.058920857,-0.054249384,-0.076875284,-0.030194271,-0.0076742466,0.008163382,0.09021848,0.017950779,-0.012056818,-0.00819098,-0.054080058,0.04488748,0.06680345,-0.08063104,0.041271776,-0.012676521,-0.052290477,-0.007620294,0.049646575,-0.102427766,0.021904405,-0.023951583,-0.06347523,0.017534958,-0.07020263,0.01419777,-0.047985487,0.022310259,-0.045810115,0.01354626,-0.016652972,0.04137082,0.05561963,-0.052744865,-0.009573651,-0.07909009,-0.05692316,-0.0060491515,0.081859134,0.116104506,0.013102614,0.05795897,0.09065077,-0.029340208,-0.006778988,-0.062098198,0.0859788,0.01719309,-0.015174209,0.08053258,-0.07352558,-0.01874412,0.044369336,-0.039984718,0.035117146,0.016948128,-0.058835514,0.00020559735,-0.020315666,-0.046624508,-0.011364583,-0.09205276,-0.0122989435,-0.05684653,0.05476119,-0.0026515115,-6.913658e-05,0.016583884,0.02216472,-0.021022873,0.040541366,-0.027351668,-0.029522672,-0.084820405,-0.00314752,0.0356516,0.016560525,-0.04335614,-0.034104742,0.02288414,0.024442477,0.063831165,0.0679617,-0.052860975,-0.013617145,-0.092357725,2.0609019e-33,0.0831722,-0.003132294,0.09681755,-0.010532586,0.06735209,-0.020860732,-0.06723363,-0.02576567,0.06494414,-0.053556394,-0.06709874,-0.097321704,-0.041803297,-0.049172316,-0.008494056,0.02186369,-0.072586425,-0.0034775243,0.062690765,-0.044424035,0.01487045,0.072392635,0.010531835,0.06661198,0.026323443,0.11450606,-0.03144964,0.024518663,-0.031271428,-0.016635874,0.024664186,-0.0733003,-0.07325104,0.021096604,0.10063308,-0.006093163,-0.039662093,-0.06825005,-0.006963026,0.053307917,0.00550549,-0.04534304,0.05048376,-0.034345098,-0.04138358,-0.041350015,-0.01821476,0.0038008124,-0.022301162,0.099103115,0.025432792,-0.050106883,0.04242006,-0.014533329,-0.05569031,-0.014407486,0.026884362,-0.074028455,0.04401076,0.087954484,0.0047700717,-0.0514843,0.009310948,-0.0513161,-0.03444766,-0.021032648,-0.0841902,-0.032247603,-0.011415067,0.1309413,-0.02965141,-0.009080976,0.021052837,0.0020322425,0.071911626,-0.00841924,-0.06065824,0.071926706,-0.020542076,0.035482746,0.08398423,-0.0044670324,0.019883208,0.071621574,-0.022568235,-0.022628522,0.009064693,-0.05944138,0.04828958,-0.02419792,-0.015743487,0.032275576,-0.030257264,0.034100965,-0.02415643,-4.638994e-33,0.040212713,-0.08615249,0.048317775,-0.02304248,-0.02144526,0.015509883,-0.0086583635,0.016276646,-0.020212753,0.022596419,0.02242639,0.020350479,-0.10733471,0.021550206,0.048486583,0.004447862,-0.009606273,0.076709084,-0.066843934,-0.005321928,-0.03750363,0.0022479983,0.019835506,0.029195359,0.12719502,-0.059506074,0.07630412,0.044775028,0.048813697,0.06539346,-0.041498445,0.0071955537,-0.0026309814,0.036925193,0.063917555,-0.017969627,-0.054444134,0.052855976,0.024044175,-0.008844295,0.072084226,0.036783967,0.062087324,0.013526901,-0.029498195,0.018519137,-0.04154172,0.008919893,-0.028291613,-0.034013607,0.057671096,-0.027542861,0.0079792915,-0.051636796,0.06009897,0.020887662,-0.013058672,0.026947223,0.018522458,-0.035508838,0.003567793,-0.06660743,-0.059463102,0.025277913,0.051835075,0.0052601886,0.074319154,-0.0058734487,0.027011566,0.0787703,0.0136491945,-0.0042636027,0.0965804,0.06599247,-0.05339828,0.00021995329,-0.09423561,-0.05779464,0.05467802,-0.03424002,0.013384399,-0.0628744,-0.029605176,-0.089016005,0.04241953,-0.044777602,0.040288623,0.119798005,-0.0074372278,0.07741923,-0.032256287,0.07203464,0.0065837577,0.06049847,-0.004981226,-3.1194013e-08,0.037763104,-0.088958494,-0.020182945,-0.003417693,-0.011049371,0.01069827,-0.017375994,-0.038206313,0.06347079,-0.008100896,-0.026912939,0.07631174,0.032587998,0.061654568,-0.040160548,0.020514188,-0.042746246,0.049307246,0.01354349,-0.035121042,-0.12208511,0.06699606,-0.07121433,-0.02090258,0.039906513,-0.018012734,-0.004384815,0.12817001,0.01936539,-0.02604073,0.052606434,-0.016558357,0.012320004,-0.10024473,-0.032880764,0.07099231,-0.024136376,-0.09833451,0.026444482,-0.0141218575,-0.0076447264,0.04440997,-0.018393945,-0.0057614744,-0.046160534,-0.004939445,-0.025754504,0.056598153,-0.018487547,0.05889482,0.041487426,-0.012248209,0.020842662,-0.04522968,-0.09892187,-0.0025867303,0.018070133,-0.09491763,0.05347125,-0.079984434,0.0054756827,0.0149684325,0.15630351,0.009340823 +2.3.2.6,"Requires a univalent cation. The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-arginine or L-lysine residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. The enzyme also transfers L-phenylalanine in vitro, but this has not been observed in vivo [5]. cf. EC 2.3.2.29, aspartate/glutamate leucyltransferase, and EC 2.3.2.8, arginyltransferase.",384,1.0,-0.025640909,-0.058050375,-0.02971757,-0.07860181,0.11306382,0.073465705,-0.057704326,0.07046047,0.046142057,-0.03273779,0.07000337,-0.012740293,-0.040091354,0.11658138,-0.050034538,0.058415644,-0.12164064,-0.028856998,0.011945203,0.009972954,0.068409,0.100935385,-0.12441338,-0.0016833562,0.06265411,0.023572378,0.05753572,-0.12375907,0.014290899,-0.026851796,0.0012362706,-0.08497432,0.026831502,-0.09742473,0.080237225,0.035387244,-0.009716077,-0.08564028,0.09867055,0.031254504,0.009215236,0.027256122,-0.055148955,-0.05976254,0.03741961,0.035177216,0.026821863,0.032238837,-0.02412432,0.047019728,0.050230402,-0.023293776,0.019915648,0.0406197,-0.010408493,-0.011102649,-0.103949174,-0.04683535,-0.023898201,0.050984226,-0.013000827,0.044817097,0.025415428,-0.039998446,0.054300915,-0.103240386,0.041423813,-0.07699492,0.040845726,0.0008659905,-0.08227999,-0.039467733,-0.005879941,0.041073088,0.029683633,0.039919343,-0.0064470703,0.017286465,-0.0071796644,-0.03447563,0.028607866,0.013632182,0.040453628,0.061840203,0.028697958,-0.07999335,-0.040894177,0.04864764,0.006697007,0.003220868,0.026027955,-0.05807931,-0.0077084233,0.012231792,0.0013714898,0.023281576,-0.05328187,-0.01483619,-0.0259854,-0.032865085,-0.056263678,0.030032644,0.0049965554,-0.08748251,-0.010509198,0.033375077,0.030729454,0.05863403,0.0040527578,-0.07444096,0.08030494,0.016179442,0.059014816,-0.015384667,0.062865354,0.050357845,-0.0062009417,-0.049331885,-0.018220974,0.034756918,-0.0042812605,-0.04324821,0.027333558,0.07762963,-0.05071168,0.13020162,-0.04186395,2.3567387e-33,0.03746783,-0.05500335,-0.019418458,-0.019488448,0.014735577,0.007489707,-0.07024098,0.032866266,0.008718151,-0.10448818,-0.018976947,-0.12014788,0.021411406,-0.0063295686,0.011599717,0.035553776,-0.013960926,0.012015673,0.07281726,0.0025347632,0.0068345657,0.023752948,0.027155373,-0.0015837471,0.062466234,0.05937562,-0.012096578,-0.007818007,0.041444853,-0.008990131,0.036193024,-0.06816994,-0.060947828,0.003086176,-0.009141126,0.009968475,0.056348514,-0.06513594,0.0062685106,0.046485983,0.010279491,0.049738813,-0.0831005,0.024656782,0.044007193,-0.062262926,-0.030916408,0.07391089,-0.07540682,0.008898889,0.03144235,-0.05561935,0.025847679,-0.083791554,-0.03751833,-0.0031267102,-0.06252429,-0.024947556,-0.009308595,0.015923746,0.056258805,0.08271727,-0.027450733,0.0014694761,0.0061048768,-0.004356959,-0.04351112,-0.06253238,0.029961633,0.010818533,-0.06404518,-0.03525485,0.023921933,0.023996219,0.028488548,-0.12950285,-0.09857922,0.098021515,0.080859855,0.018713398,0.045435067,0.02773494,0.024284154,-0.06485397,0.027770514,-0.053191446,-0.008516406,-0.09427457,0.0064912387,-0.013380241,0.013851905,-0.023536494,-0.015879016,0.08060034,-0.059565194,-2.704792e-33,0.05773643,-0.11176302,0.016453557,0.0016218233,-0.071505226,0.07946408,0.005755874,0.010179536,0.03332023,-0.042506713,0.061005037,-0.0023198668,0.061947804,-0.022611115,0.085671544,0.004155146,-0.034994777,0.05545008,-0.015751407,-0.05610907,0.0025907895,-0.004026813,0.015122675,0.044006847,0.047770455,0.034626164,-0.10390329,0.028391939,0.024360262,0.035858333,0.010541877,-0.00089804886,-0.037820775,-0.030986479,-0.049893916,0.019372744,-0.04292117,0.012675526,0.011857237,-0.013469155,0.031093521,0.044956964,0.028802875,0.02474806,0.0019962,0.0027868096,-0.035822056,-0.010727973,-0.0040042154,-0.123887226,0.0012438182,-0.05692843,0.009384938,-0.011635551,-0.07689413,0.07017969,0.02916199,0.071434066,0.031070102,-0.030474937,-0.027592098,-0.09285559,-0.0002207125,0.053734597,0.11517081,0.01708588,0.01542784,0.0817668,0.015315646,-0.080076635,0.0012984782,0.002666723,0.06564656,0.066277474,-0.015467123,0.012590167,-0.0782527,-0.0809031,0.075513765,-0.051990766,-0.09600938,-0.07234756,-0.0048316787,-0.059795246,0.024892561,-0.05955906,-0.0067369593,0.06587571,0.03890491,0.04157027,-0.032918043,-0.0667426,-0.030834654,0.00085966085,0.07757259,-4.525796e-08,0.05552955,-0.012202578,-0.0072755967,-0.003632724,0.00041746587,0.018868364,-0.046060592,0.025981136,0.05156303,-0.023225969,-0.0031230664,0.05053704,-0.044951092,0.031129733,0.01727906,0.04788941,0.0651578,0.022328312,0.011510593,-0.00053972565,-0.080993846,-0.02524219,-0.025959339,0.03442478,0.045446113,-0.070853956,0.021085583,0.12271279,0.03522891,-0.06666843,0.016483122,0.008982853,0.027266009,-0.01290024,0.015580472,0.050480053,-0.01849676,-0.04604155,0.019409854,0.12015439,-0.0020878208,0.04112965,-0.05416649,-0.037626546,0.032207973,0.0003815411,0.09234259,0.014872527,-0.14473517,-0.043135885,0.09182721,-0.11943659,0.0009335635,-0.01899214,-0.051878206,-0.04383978,-0.035637666,-0.060595725,0.056748293,-0.051124927,-0.042442232,0.072842754,0.13690527,0.0073312554 +2.3.2.8,"Requires 2-sulfanylethan-1-ol (2-mercaptoethanol) and a univalent cation. Peptides and proteins containing an N-terminal glutamate, aspartate or cystine residue can act as acceptors.",384,1.0,0.0030990045,-0.106566735,-0.025664415,0.019989327,0.0118746655,-0.019593969,0.030637302,0.0355033,0.070637494,-0.0343957,0.076706596,-0.065301746,-0.07637577,0.1072036,-0.013648493,0.026763115,-0.040426224,0.010416858,-0.017949997,0.013476674,0.036298037,0.09613833,-0.009728084,-0.04515773,-0.06591012,0.023421958,0.010919732,-0.03055947,0.07126577,-0.06711604,0.012478166,-0.0609172,-0.0040865545,0.017774174,0.0043913354,0.019480271,-0.07008872,-0.06561857,-0.01445397,-0.07595558,0.08392425,0.017474242,-0.014855332,-0.050022744,-0.024548465,-0.10495539,0.047413602,-0.013048998,0.02656391,-0.08090247,0.028027246,-0.020377861,-0.0012039815,0.07770413,-0.06047666,0.029237188,-0.15094781,-0.04767224,0.016312836,0.0007193212,-0.05371007,0.03144754,-0.0158888,-0.07191535,0.06556367,-0.030631488,0.040037647,-0.065997064,-0.004176556,0.041086406,-0.031920426,-0.08399271,0.03396144,0.03495782,0.052251056,0.040587336,-0.0042873523,-0.0048625534,0.056148663,0.014089257,0.0076884557,-0.040212564,0.044313688,0.10406608,0.0830079,0.011661838,-0.045772523,0.0687283,0.002163041,0.031297125,0.022876248,-0.01095529,0.057333358,-0.09138429,-0.0070847063,-0.05761485,0.053622723,0.016630199,0.023717076,0.082240544,-0.060626063,0.06968475,-0.011683489,-0.05317879,-0.026282083,0.03588566,0.026168238,-0.023534821,0.006367438,-0.058304984,-0.014204757,-0.08798805,0.05678034,-0.00963511,-0.043282222,0.035427857,0.012957202,-0.07195863,-0.00893418,-0.07048336,-0.043849394,-0.0347554,-0.018703407,0.02916232,-0.05066515,0.057619713,-0.08611253,3.3296594e-33,0.013167474,0.030308615,0.056712594,-0.012095608,-0.025951443,-0.007591533,-0.0570941,-0.021311106,0.08540738,-0.06496798,-0.07726684,-0.072107024,0.028541133,0.054633953,0.03588535,-0.032297038,-0.02169539,0.03601752,0.10328811,-0.09926841,-0.010693695,0.01840509,-0.033750437,-0.016669286,0.017425785,-0.009873141,-0.015330027,-0.0030083156,0.10283157,-0.0051398226,0.049122315,-0.038881537,-0.033776518,0.05273149,0.021222265,0.008230267,-0.021556927,-0.031356864,0.04708925,-0.038672637,-0.018383797,0.053537887,-0.04449029,0.014055022,0.044938598,-0.031514574,-0.025639005,0.034214173,-0.042998713,0.074999854,0.021703543,-0.030731527,-0.04563634,-0.06887292,-0.057085868,-0.023630226,0.010290705,0.0002911733,0.05095974,0.043706875,-0.063398145,0.017626753,-0.06681653,-0.0387373,0.011142065,0.07523878,-0.073876746,-0.07598856,-0.031281002,0.008122973,-0.083678976,-0.038606375,0.0076054307,0.048591338,0.0050044702,-0.051259123,-0.027784659,0.008120728,0.051889796,0.04286262,-0.07306196,-0.06442829,-0.051688466,0.094553165,-0.038954478,-0.06561103,0.031829357,-0.06265722,0.015843155,0.015222527,0.0017814669,-0.015086313,-0.053642187,0.022100896,0.03030537,-5.0912093e-33,0.068937644,-0.054678574,0.029303001,0.025690494,-0.03128302,0.0836884,0.0050306357,-0.07953996,0.07393833,-0.06251815,0.088576235,0.05822827,0.09204387,-0.0065108514,0.010391619,0.042039666,-0.025840985,0.0971958,0.004978655,0.0067518423,0.021367537,0.08387716,0.0013673212,0.08122057,0.055464126,0.05001942,0.008474817,-0.01779571,0.018876437,0.08281677,-0.022314858,0.026472047,-0.0027552473,-0.12636743,-0.0032406219,-0.013016673,0.022790382,-0.023958128,-0.086879686,0.025457446,-0.0014609743,0.037817303,0.030718848,0.16293369,0.015420674,-0.020501021,0.0010834719,0.0014665738,-0.028100237,-0.06719291,0.030003183,-0.011274246,0.0008457618,-0.044502903,0.048847407,0.07463758,0.09300666,-0.09235389,0.0059250146,-0.03356813,-0.021202458,-0.039438356,0.005125588,-0.08966962,0.03240326,-0.07616256,0.016701544,0.007134454,0.033552658,-0.06323683,0.060518146,-0.008347462,0.09666057,-0.0043704887,0.024331227,-0.0036979814,-0.06014336,-0.015515409,0.058491558,-0.06520731,-0.081637725,0.024233485,0.04050084,-0.052571036,0.07101702,-0.086324416,0.015860273,0.04550787,0.006953129,0.048707776,-0.02296561,-0.02334931,0.033789024,0.1209886,0.058053207,-4.3742023e-08,0.011301541,-0.022301063,-0.018705638,-0.044957675,-0.03544875,0.08288694,-0.04223523,-0.052248467,-0.01678967,0.032164093,0.059959415,0.1298815,-0.04836923,0.0006333884,0.028533129,0.042301886,-0.030030148,0.041700505,-0.07238579,-0.049959656,-0.09753202,-0.02011405,-0.08097,-0.028033933,0.056822542,-0.06748129,-0.01936657,0.06066517,-0.07315903,0.0066668983,0.07830999,0.01256639,0.008312367,-0.051523816,0.0062724934,0.026829548,0.022759382,-0.075227715,-0.020803906,-0.01950455,0.031103058,0.07337742,-0.09357653,0.010029906,-0.013416799,0.032802574,0.013228851,0.056753647,-0.12495129,0.039961938,0.05825921,-0.053710155,-0.009890872,0.0028919056,-0.08061283,-0.023632025,-0.0015664377,0.0022870763,-0.000225988,-0.0759765,0.09869605,0.034931045,0.13839392,-0.0010982396 +2.3.2.9,"4-Hydroxyaniline, cyclohexylamine, 1-naphthylhydrazine and similar compounds can act as acceptors; the enzyme also catalyses the hydrolysis of agaritine.",384,0.99999994,-0.10018822,-0.078995116,-0.0022851313,0.0045707477,0.034013715,-0.02145234,0.039723363,0.06505264,0.012306898,-0.026288789,-0.0019409751,-0.017159874,-0.05947184,0.02102932,-0.06417151,0.07012238,-0.08124871,0.036227867,-0.041143656,-0.012183553,0.025681391,-0.0022983989,-0.004503742,0.0016887394,0.0873511,0.014190979,-0.03478792,-0.018317932,-0.0102123795,-0.08331893,0.013077368,-0.08177851,0.12196453,0.019427126,0.021691615,0.017856454,-0.040801313,0.0058355364,0.017447555,-0.04308866,0.057947766,-0.022754773,-0.0061876397,-0.0904657,0.006720053,-0.026368042,-0.01981545,-0.05773537,0.03589118,0.016024414,0.010684414,-0.06282421,-0.06694293,0.0609653,-0.0046340716,-0.057642512,-0.0871564,-0.049269795,0.019201046,0.081186615,0.024884386,-0.021874703,-0.08262921,-0.052822996,0.019068176,-0.02203683,0.007413018,-0.034165762,0.01756133,0.0022350608,0.009957338,-0.095084615,0.03162947,0.0143958,-0.0014741953,-0.03003941,-0.037835754,0.01204511,0.07834451,-0.019323217,-0.012785053,-0.0054211323,0.024625797,0.09772461,0.037375864,0.046812158,-0.009977919,0.06006421,0.08532945,0.05466757,-0.030305162,0.023914978,-0.011571429,-0.024512656,0.006282646,0.0017010439,0.038599063,-0.088490434,0.04396074,0.037445195,0.05948301,0.06081047,-0.06809795,-0.07917946,-0.088743486,0.003020041,0.07277832,0.023414308,-0.02056455,-0.015489467,-0.028478157,-0.076023936,0.0031450333,-0.0027931528,-0.08069027,0.031375527,0.028455062,-0.093186446,-0.05811359,-0.0921042,-0.058014873,0.0002808038,0.08385488,0.08158842,0.03343358,0.040145416,-0.04856743,3.4972845e-33,0.0011248034,0.038152818,-0.009485881,-0.04757103,0.018733295,0.016271248,-0.09603601,0.11030678,0.0118558295,-0.036869407,-0.10740741,-0.04394183,0.042498387,0.015379876,-0.040112168,-0.071437135,0.063327335,-0.025319338,0.06915314,-0.047674265,0.049308933,-0.0071940366,-0.020826621,0.03139272,-0.02231941,-0.033277754,-0.014703841,0.033760846,0.052162375,-0.013315026,0.021350313,-0.063420855,-0.013447234,0.054701958,-0.029123351,0.07931288,-0.06386847,0.0026437,0.01560614,0.10756581,-0.052267395,0.062045574,-0.023644792,0.025285315,0.052031018,-0.019270647,-0.04726108,0.11827245,0.028270938,0.055155035,-0.005326525,-0.04178914,0.047991935,-0.021186631,-0.04912965,0.05045394,-0.07652297,0.016640652,-0.032194246,0.036768228,0.05920262,0.064817995,-0.045393836,-0.07134365,-0.04850511,0.08225675,-0.066513345,0.02464655,0.010451939,0.04473097,-0.11882385,0.008939408,0.05220727,0.06410847,0.04286421,-0.025042554,-0.032761943,0.015483106,0.008950533,-0.016951362,-0.0067818747,-0.02870308,0.06730598,0.11034553,-0.06449692,-0.0029560549,0.021754554,-0.035740916,0.0031638863,0.029094148,0.06771542,-0.08529248,-0.050632875,0.018613433,0.0037210411,-3.991216e-33,0.14326434,-0.05305231,-0.013509502,-0.064641945,0.011149116,0.03845268,0.0019425486,-0.07414842,0.047314074,0.016220074,0.042414654,0.04907101,0.09235754,-0.027445193,0.017119443,-0.03055781,-0.026072904,0.047859006,0.021041792,0.008786725,-0.08905998,0.08944341,0.03318897,0.009688007,0.051831387,0.015236458,0.01549869,0.020861544,0.06132431,0.102659486,0.00023762768,0.00556951,-0.005004911,-0.12065401,0.01964038,0.09321556,-0.009736067,0.045990445,-0.05480723,0.0036688838,0.005669406,-0.03138797,0.014716717,0.06055659,0.048748933,0.055585433,-0.047633946,0.06788293,-0.11668603,-0.036674086,0.051850602,-0.008802379,0.0038395473,0.017973939,0.077883564,0.057322156,0.040038817,-0.05403785,-0.09314653,-0.051093113,-0.036647424,-0.06098434,0.07478076,-0.027744854,0.020765014,0.011178866,-0.025396788,0.09380578,-0.023280311,0.004275699,0.06345977,0.009460123,-0.0029467333,0.013165708,-0.0038913481,0.038258225,-0.0008599151,-0.07160666,-0.037858833,-0.07655592,0.007755991,0.05320082,0.030801143,-0.084722415,-0.06301736,0.022450488,0.011710743,0.10354286,-0.027850352,0.035398237,-0.02628034,0.025758049,-0.011248486,0.12515457,0.032983113,-3.3849506e-08,-0.026929082,-0.01651966,0.008592961,-0.0058024316,-0.08265466,0.06861529,0.020804882,0.0208617,0.01669287,-0.09683131,-0.0703449,0.11767488,0.01734986,-0.048295077,-0.0031516738,-0.055520087,-0.008673303,0.032883026,-0.05979724,-0.022418384,-0.11286966,0.0052353954,-0.104045816,-0.0040324084,-0.037743986,-0.07152605,0.008724273,0.014490164,-0.001912003,-0.025033988,0.06469232,0.051164545,0.031618793,-0.11084942,0.028160904,0.040680338,-0.006787581,-0.07423018,0.014756324,-0.0042354497,0.07946998,-0.01742268,-0.057299506,-0.015272105,0.010985229,-0.0005057645,-0.03164277,-0.035819292,0.02340951,0.046379074,0.08549072,0.020247791,-0.035300627,0.014279866,0.017965592,-0.035720512,-0.032574456,-0.09916745,-0.020722935,0.004337107,0.0054566525,-0.021629475,0.17115122,0.01182523 +2.3.2.10,Also acts on L-seryl-tRNASer.,384,1.0,-0.054582797,-0.12470584,-0.013651182,0.024570828,0.021769272,0.06346396,0.044701748,0.022752522,0.04626314,-0.02556129,0.09387906,0.011070288,-0.09725921,0.06832465,0.031933416,0.049335223,-0.06925004,0.0055663222,0.010302279,0.008778186,0.008997767,0.06683574,0.025388252,0.0044046505,-0.039769266,-0.07171855,-0.008456221,-0.03680886,0.024073994,-0.1029066,0.0083684875,0.018119868,-0.035986118,-0.04875984,-0.05031555,0.033818077,-0.09767975,0.013356502,0.08423209,0.023871966,0.06030968,-0.11694052,-0.002233329,-0.0744148,-0.102529764,-0.08683654,-0.006129603,-0.012853424,-0.024853067,0.060574424,-0.04919578,-0.06626096,-0.010864212,0.054250505,-0.09471651,0.031567443,-0.06667934,-0.014803078,0.034447946,-0.05755391,-0.031015357,0.08693241,-0.017905938,0.025422562,0.010696536,-0.031401537,0.053758875,-0.046401087,0.002412328,0.026474372,0.021092873,-0.07465488,-0.026213001,0.04469676,-0.022967575,0.022768168,0.028465727,-0.048299834,0.016863285,-0.00048063803,-0.028997807,-0.028153252,-0.036089238,0.049683943,0.018874401,-0.027995171,-0.036594175,-0.011378472,-0.0003021322,0.020854281,0.04758651,-0.06886041,-0.0952216,0.039538693,-0.06483397,0.024996439,0.021797063,0.06823294,-0.06109375,0.0241803,-0.07413131,-0.035008617,0.027609007,-0.05262516,-0.066220954,-0.05561837,0.021429114,-0.067459576,-0.065269925,-0.07058131,-0.013204621,-0.061589494,0.05375781,0.0033801128,-0.007077719,0.025935268,0.009931912,-0.013034875,-0.005931574,-0.038310386,0.046745602,0.015196737,0.042266652,0.07700086,0.0068219416,0.087837175,-0.09653735,-3.5627265e-33,0.046435103,-0.038062572,0.018777557,-0.014951496,0.09203827,-0.064997785,-0.059254598,-0.025407372,-0.0068953917,-0.003935356,-0.046457212,-0.06462873,-0.0032402,-0.013603715,-0.03023641,0.016997691,-0.0034086234,-0.008482559,-0.011761029,-0.029955825,0.016755544,0.17302684,-0.0239539,-0.002730507,-0.00636007,0.0037186795,0.048021745,0.008891155,-0.012630596,0.020545881,0.06339557,-0.0078120874,0.023518043,0.0034954287,0.0786368,0.07903099,-0.10929731,-0.030452225,-0.07757533,-0.02267971,0.076355934,0.056695707,-0.10395115,0.018169317,-0.060920924,-0.042799238,-0.04172735,0.061674345,0.0394627,0.004151332,0.1193724,-0.036156897,-0.012694469,0.0087554725,0.021333162,0.06575954,-0.012710918,0.014546172,0.07835219,0.09148316,0.035702102,-0.004309389,0.029055214,0.015316523,0.024899192,-0.012890683,-0.044134144,-0.01602623,-0.02920754,0.041969698,-0.08336343,-0.051219486,0.14434567,0.007740976,0.038639367,-0.060697656,-0.06141096,-0.054292414,-0.05454571,0.050817598,-0.043715864,-0.08993257,0.039225556,0.013030846,-0.0202565,-0.049077667,0.024963489,-0.1125374,-0.028801983,0.022706823,0.05192226,-0.010860709,-0.004230135,-0.021163125,-0.049986836,-1.546651e-34,-0.011292421,-0.060802113,0.058442466,0.05647769,-0.0387225,0.059806626,0.0114187645,-0.0059931553,0.008735873,0.01345646,0.047783967,0.05069321,-0.04854657,-0.04469899,0.11472488,-0.0032433828,0.08676858,0.043880746,-0.029328369,-0.012385872,0.015360029,0.06766432,0.004292182,0.053199798,0.017506883,-0.0074715246,0.017001813,0.09401986,-0.04693132,0.045119863,-1.8176885e-05,0.009953152,-0.019071538,-0.07626015,-0.06850516,0.0733635,-0.023895063,0.010797564,0.02546636,-0.03198231,0.0461139,-0.060967863,0.08486977,0.13792947,-0.005118396,-0.039387837,-0.004256264,-0.036415234,-0.100332566,-0.0334319,-0.02258882,-0.00060267234,-0.014171271,-0.024625694,0.05274596,0.1096854,-0.02113883,-0.112860076,-0.030031258,0.012079651,-0.02729592,-0.019242277,-0.057126254,-0.047983233,0.07714678,-0.041360445,-0.03975218,-0.014266248,0.07587009,-0.008661472,0.09249976,0.022076447,-0.061490502,0.05192793,-0.025827434,-0.06087442,-0.029257633,-0.072482996,0.005939388,-0.06873402,-0.0832456,-0.07697007,0.032179292,-0.058636237,0.029286325,-0.008019323,-0.087162465,0.08844184,0.05381776,0.04597876,0.014858559,-0.020736214,0.019660307,0.021216772,0.010227945,-2.0725546e-08,-0.046191245,-0.026189713,0.05244043,0.027777463,0.015434196,0.033148672,0.011638771,0.037257172,0.0045578023,0.06395808,0.024122793,0.0741549,0.06652251,-0.0037921388,0.11316479,-0.018753575,-0.016575681,0.1024957,-0.104654856,-0.023040866,-0.083477564,-0.024334775,0.020077629,0.01386838,-0.020290747,-0.015630683,-0.018399836,0.08949985,-0.0050966195,-0.0010512299,0.07278866,-0.005011606,-0.017638264,-0.0013437954,-0.026778255,0.039368447,0.0015857295,-0.07918637,-0.003520489,0.12861851,0.00916867,0.039155416,-0.013856018,0.071861275,-0.05601757,0.023823151,-0.02889558,-0.031103827,-0.02245333,0.03190055,0.10913226,0.018461188,-0.0131208375,0.039738495,-0.058825582,0.060199227,-0.02055197,0.040569063,0.009856406,-0.023566373,0.08516437,0.0058168494,0.082159296,-0.004093992 +2.3.2.12,"The enzyme is a ribozyme. Two non-equivlant ribonucleoprotein subunits operate in non-concerted fashion in peptide elongation. The small subunit forms the mRNA-binding machinery and decoding center, the large subunit performs the main ribosomal catalytic function in the peptidyl-transferase center.",384,1.0,0.025102986,-0.066222526,-0.06967274,-0.045278046,0.05400053,0.019858534,-0.060222883,0.032689705,0.096549325,-0.013370951,0.011975164,0.020478055,-0.030180981,0.07050488,-0.048226967,0.03421499,-0.09356895,-0.004274992,-0.013196427,-0.06693133,0.056305174,0.05159095,0.010726254,0.058467448,0.046773937,-0.011724682,0.017648978,-0.050200574,-0.016294504,-0.05621187,-0.014638692,-0.039545428,0.05895263,0.055242725,0.012085744,0.08182086,-0.040271603,-0.07056066,0.013390615,0.006757498,0.05812093,0.019708771,-0.029388664,-0.07025748,-0.056655724,0.018309014,-0.023662407,0.12941805,0.0061204163,0.024611428,-0.016083332,-0.10726397,-0.09290408,-0.028306494,0.031834237,0.09220939,0.0030751396,-0.071796045,0.005104765,-0.048790272,0.032734446,-0.012882611,-0.0012427686,0.044840164,0.0067620063,-0.07397853,0.0067841606,-0.028280474,-0.0123321535,-0.03932128,0.004358967,-0.090159625,-0.08217652,0.07493891,0.07267144,-0.03900956,0.016621536,5.051472e-05,0.053527497,0.020504916,-0.02015604,0.0013494608,0.041500337,0.050286483,0.0048125545,0.09845773,0.03551923,0.024612,0.024496667,-0.040169448,0.026211472,-0.041852094,0.03897827,-0.039983507,-0.056593835,-0.01963253,-0.017483627,0.016067991,-0.06326906,-0.04631016,0.04312691,0.07157427,0.049284037,-0.081454925,-0.025034633,0.05913199,0.014305817,0.08029656,-0.0038170407,-0.01810021,-0.010220234,0.02604946,0.0679809,0.006273336,0.030909691,0.08936883,0.0020878988,-0.026136694,-0.014021446,0.06827446,0.017413085,-0.018410614,-0.00050672906,0.101519085,-0.04706604,0.05662451,-0.08542774,3.0462216e-33,0.027089234,-0.030504163,0.075950705,0.045427367,-0.074621916,0.046473116,-0.07603231,-0.008352312,-0.012013222,-0.04654696,-0.085435964,-0.08381008,0.09777941,0.028730156,0.020721503,-0.10254587,-0.041888673,0.060497984,0.028853787,0.03763225,-0.003037445,0.0986758,0.0047548544,0.037154265,0.025194537,-0.011112717,-0.010183083,-0.049129177,0.07142818,0.011058924,-0.03618984,-0.014799548,-0.146757,0.047695473,-0.030896896,-0.033999644,0.024577836,-0.07119484,0.044708896,0.057744432,0.01255021,-0.03213145,-0.014156739,-0.06562648,0.0654034,-0.03657273,0.01317111,0.047035813,-0.06576742,0.006336686,0.06526357,-0.01551399,0.099184416,-0.037404947,-0.045408636,0.054462574,0.004291071,-0.016777188,0.055208694,0.00096417725,-0.018443659,0.012580604,-0.020646654,0.043058645,0.0015120644,0.007134111,-0.060896076,-0.117183104,0.012173954,0.120138384,0.00049260416,0.02427241,0.108791,0.021655489,0.007737034,-0.06282617,-0.11963966,-0.04390636,0.022863496,0.074728556,-0.060401164,-0.01600606,-0.036065586,-0.019313442,0.03143613,-0.07857934,0.06424209,-0.07008697,-0.050237767,0.04881397,0.018464603,-0.015815133,-0.08530797,0.05169558,0.06402722,-2.9028958e-33,0.113649204,-0.16555549,0.030733105,-0.013301046,-0.081470504,-0.02543427,0.013552131,-0.036198348,0.02738849,-0.09131667,0.026308386,-0.025337959,0.0040951176,-0.061414022,0.048090212,0.022608504,-0.022731964,0.02729975,0.028921552,0.062349904,0.012755918,-0.046025507,-0.014233264,0.009691756,-0.00025622104,0.0068294327,-0.03117028,0.059910145,0.06417068,-0.03125223,-0.07474265,0.0359128,0.011340592,-0.0033582964,-0.081700645,0.09631714,-0.024555879,0.018581184,0.05178668,-0.041828103,-0.03924524,0.09264811,0.014358751,0.035264924,0.05879967,0.06791098,0.015292239,0.010465007,-0.06903645,-0.04894905,0.0020940872,-0.01174802,0.0386559,0.10811044,0.020131318,0.021460142,-0.012781018,0.047114495,0.018189106,0.0026452744,-0.03003656,0.004651608,-0.0054823,0.0127027435,0.0349247,0.00731162,-0.046512425,0.042836547,0.004665937,-0.044820234,0.077489205,-0.03990395,0.06202662,0.024331536,0.03639482,-0.028784558,-0.063207515,-0.043745387,-0.038774956,-0.09327277,-0.083030015,-0.016123492,-0.031756774,0.015440915,-0.00031921096,-0.11658111,0.063104086,0.09859456,0.0023282443,0.07791293,-0.027597042,0.015158184,0.057875294,0.0394202,0.12830631,-3.923181e-08,0.023995712,0.008799266,0.032971114,-0.08087419,0.04124359,0.030637965,0.022144755,-0.043472204,0.0019408498,-0.007348914,-0.013623638,-0.008533296,-0.023842618,-0.01136468,0.05189052,0.07044553,-0.056286,-0.040126037,0.003248485,0.0067893686,-0.038171124,0.052770797,-0.07897627,0.025853487,-0.105032064,0.00044562694,0.013699161,0.033617284,-0.014162572,-0.06096046,-0.036595497,0.09743803,0.03918223,-0.05605781,-0.04743379,0.05972852,0.031546604,0.009402582,0.024512842,0.0048314673,0.021535365,-0.10386713,-0.03013074,-0.09998045,-0.03848736,0.012048834,0.011787819,0.0029105616,0.0069788336,0.019226048,0.04628052,0.0127771525,-0.02000581,-0.041521966,-0.044797473,-0.019530978,-0.047943044,-0.106481045,0.06292187,-0.03361968,-0.018730951,0.013622091,0.12179828,-0.054316457 +2.3.2.13,"Requires Ca2+. The gamma-carboxamide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N6-(5-glutamyl)-lysine crosslinks. Formed by proteolytic cleavage from plasma Factor XIII",384,1.0,-0.038162842,-0.11593605,-0.018583668,-0.040581327,0.08062117,0.041511495,0.011476413,0.03016205,0.03516643,0.011830807,0.029917534,-0.037921946,-0.04235985,0.039275356,-0.011137969,-0.009962134,-0.068333134,-0.049638562,-0.06644531,-0.022637159,-0.016877405,0.04354918,-0.052159633,-0.02612582,-0.004554861,-0.091086425,-0.0035867784,-0.038666643,0.06939856,0.029713774,-0.018218722,-0.047110606,-0.11668912,0.005142941,0.06677865,0.015148076,-0.07960836,-0.033447277,0.06907047,0.005690582,0.019487692,0.02804323,-0.010926655,-0.022849794,0.029097326,-0.015079238,0.001401472,0.076260485,0.05119926,0.087747954,0.01722942,-0.0008059626,0.007856936,0.02787947,-0.042098958,0.027785895,-0.16168319,-0.054928347,0.0013250128,0.06127168,-0.088845976,0.029971443,0.03904453,-0.08295906,0.092078656,-0.039763704,0.03201328,-0.012296178,0.022078617,-0.008184138,-0.049774848,-0.045524657,0.059143703,0.008363895,0.046809588,-0.0047973287,-0.088748604,0.022767097,-0.01343522,-0.024239225,0.044161797,0.004745992,0.073166825,0.13883676,0.035225786,-0.038966056,0.01044995,0.073202096,0.0017806876,-0.019578813,0.09537239,-0.07736578,0.03806814,0.027448934,-0.011646862,-0.042509556,-0.0049427412,-0.060932897,0.032713078,-0.0035904814,-0.036012135,0.030964317,0.01832748,-0.020169308,-0.016645864,0.023107413,-0.01234881,0.081596665,-0.0185865,-0.0234506,0.046044465,-0.017163938,0.03963758,-0.04339231,-0.027933706,0.09627005,-0.039215423,-0.001695632,0.0033055057,-0.11170537,0.06481747,0.055286326,-0.011224083,0.06296688,-0.05928019,0.06271099,-0.041240126,1.2887309e-33,0.03232415,0.04403766,0.09893199,0.012299334,-0.022079786,0.036770876,-0.110730104,-0.029554045,0.014634954,0.024897015,-0.073797464,-0.04012208,0.04288952,0.0010154373,0.018725595,0.058278643,-0.06840749,-0.079575315,0.068432674,-0.0055352706,0.03899738,0.044232257,0.014445359,0.009195749,-0.023908898,0.14515509,-0.000115640934,0.018668035,0.020863146,0.018810248,-0.09267581,-0.056125175,0.0125316745,0.05527997,0.037658464,0.02639792,-0.017815018,-0.06392212,0.03537205,0.096284606,0.017779216,0.03446589,-0.044746395,-0.0631212,0.072244346,-0.086734556,-0.0052423044,0.02739676,-0.101018935,0.055250604,0.0025046144,-0.06679684,0.06497689,-0.028917497,-0.028749932,-0.011708002,-0.059650198,0.00091972004,0.0023498458,0.05201946,0.02836548,-0.035968818,0.009232771,0.03327355,-0.028495306,0.0105836755,-0.025745666,-0.03040604,0.007381051,0.027354173,-0.06652786,0.018740878,0.060170844,0.061156332,0.030126814,-0.023555242,-0.05529218,0.1006958,0.035901487,-0.027453747,0.018992722,0.029342463,0.022589905,0.054420352,-0.0074639246,-0.04505097,-0.023156239,-0.049498226,-0.016131017,-0.04868873,0.022219287,-0.033741288,0.048177727,0.04816223,-0.05328667,-3.0629493e-33,0.13597962,-0.086064,0.058464106,-0.05692469,-0.0021184806,-0.024422491,0.022166833,-0.087432906,0.06445279,0.036810428,0.034078676,0.040108085,-0.049166452,0.001550619,0.023699384,0.041277595,-0.0359192,0.08401151,0.011915473,-0.06720175,0.017566163,-0.01945279,0.08991664,0.006210086,0.060227167,0.016170563,0.059071593,-0.057355534,0.07188589,0.04385429,-0.060201477,-0.027824001,0.012939405,-0.117965914,0.052686725,0.034250755,0.005878472,0.030072875,-0.030046113,0.03256865,0.021396013,0.033518374,0.07378268,-0.008671667,0.010480519,0.04764145,-0.052784882,-0.008308692,-0.05697236,-0.06226532,0.028608184,-0.11304541,0.025980739,-0.060848422,-0.044972222,0.06821483,0.07690184,0.026452444,-0.017288255,0.07399696,0.03500699,-0.04227574,-0.026622506,-0.031643037,0.025484491,-0.05894924,0.028966686,0.018868903,0.030231686,-0.053231977,0.02141865,-0.08419949,0.039754156,0.041880343,-0.025597017,-0.0017468792,-0.055320248,-0.045251768,0.08492237,-0.058476053,-0.035980117,-0.058282435,0.0035473784,0.022070779,0.017308272,-0.014118766,0.022919599,0.12894288,0.037995405,-0.0025117723,-0.029942146,-0.049742535,0.03397558,0.06311929,0.060354277,-3.8067146e-08,0.14323369,-0.035208657,-0.07075103,-0.055296525,-0.08645295,0.07622019,-0.05704145,0.00826006,-0.036979266,0.007437795,0.041397385,0.043922514,-0.009729568,-0.0017787499,-0.10310821,0.057938308,-0.079579696,0.0150068905,-0.07089281,-0.013693221,-0.059345137,0.0046455963,-0.00022253397,0.003869738,-0.019753963,-0.08366325,-0.017490882,0.06101111,-0.0502495,-0.07135823,-0.013863579,-0.013199644,-0.058252193,-0.10563191,-0.069065735,0.06017369,0.012093866,-0.06527724,0.048829764,0.023293503,-0.0061449674,-0.00022935997,-0.059003264,-0.034965817,0.06540941,-0.009001643,-0.008559159,0.0013544363,-0.059448145,0.08848935,-0.014394428,-0.035992354,0.0023457792,-0.02114089,-0.05144186,-0.0097267255,-0.07940563,-0.009566329,0.08801037,-0.12074629,-0.005087679,0.029363073,0.11250086,-0.0074732243 +2.3.2.14,"D-Phenylalanine and D-2-aminobutyrate can also act as acceptors, but more slowly. The enzyme also catalyses some of the reactions of EC 2.3.2.2 (gamma-glutamyltransferase).",384,0.99999994,-0.06493131,-0.09400866,-0.040827204,-0.041771267,0.0474823,-0.0077440087,-0.03336816,0.010075875,0.03650391,0.018066902,0.10249309,-0.04404034,-0.05886819,0.046716057,0.046220906,0.045925684,-0.052864987,0.01853586,-0.041924063,-0.038037725,-0.034115065,0.038599487,-0.023431908,-0.019484669,0.018186312,-0.009488769,0.043041594,-0.06005447,0.005902366,-0.06111965,-0.015052088,-0.122334756,-0.014415335,0.011117571,0.024291143,0.035536755,-0.05261549,-0.032370634,-0.014188089,-0.0038015386,0.015542883,-0.00362842,0.013040264,-0.055782773,-0.03284606,-0.034491535,0.018950867,-0.006401956,0.01368323,-0.0671043,0.01220421,-0.026310153,0.008907176,0.010097725,0.041058205,0.063733704,-0.10226143,0.0056636105,-0.008427442,-0.00880796,-0.031209135,0.007165988,0.0014286976,-0.066285394,0.031055508,-0.057059586,0.043015156,-0.084160745,0.06063109,-0.038976025,-0.03198415,-0.079828426,-0.03468312,0.010676252,0.053965177,-0.05599439,-0.048820637,0.024883924,0.08425958,-0.04660296,0.0069582476,-0.08962834,0.044999003,0.03422111,0.031641915,0.0048342342,-0.03384174,0.067365594,0.02401737,0.008318282,0.019455146,-0.04261247,0.04435963,-0.005650918,-0.0155473575,0.026069982,0.056490056,0.028138239,0.036198646,0.01950631,-0.026145924,0.09263691,-0.108727366,-0.04012756,-0.06552913,0.0021231282,0.010439246,0.07061005,-0.040659014,-0.02127833,0.052091092,-0.08611396,0.070673816,0.06797395,-0.06452651,0.10827436,0.035948984,-0.08317838,0.008034026,-0.057783347,-0.00595291,0.009260127,0.092342734,0.08946065,-0.01935522,0.09145841,-0.063384674,1.3946487e-33,0.027731014,-0.012896564,-0.007421597,-0.013206975,-0.066804186,0.035176907,-0.11064868,0.07055423,0.058918417,-0.112327725,-0.15245181,-0.09455882,0.06390065,0.09231623,0.0013901275,-0.03096381,0.0075873015,0.028061237,0.06083515,-0.013377668,0.042305816,0.012035434,0.006708081,0.032059286,0.026963351,0.005758051,-0.05255038,0.0647617,0.06633566,0.007195767,-0.028713217,-0.11080675,-0.02141628,0.040335555,-0.041982774,0.04890174,-0.044137992,-0.0059076003,0.03306545,0.03479038,-0.0433833,-0.0052077947,-0.07276163,-0.02044545,0.006956513,0.053884108,0.03841287,-0.007392043,-0.058623582,0.046099987,0.03035175,-0.03248567,0.021476045,-0.043773696,-0.008163973,0.016897125,0.020317204,-0.03300793,0.037352864,0.11521532,-0.043413922,0.09781261,-0.010295325,0.0085657,-0.03670199,0.020989954,-0.027750531,-0.035945937,-0.038482334,0.032434877,-0.051702123,-0.01949855,0.113946274,-0.0006386761,0.07726604,-0.12100597,-0.025634283,0.0060558263,0.008777238,-0.011365329,-0.01735874,0.006672881,-0.0040773926,0.045119245,-0.019292278,-0.04186093,-0.032298066,-0.12053231,0.03891654,0.07208126,-0.06368365,-0.03502998,-0.07471005,0.05397894,0.08898738,-2.5804711e-33,0.043981086,-0.056320745,-0.019013682,-0.010595501,-0.0032799134,0.07319385,0.02999906,-0.019197421,0.12060912,-0.047337778,0.061643373,0.03249545,0.014725966,-0.007933068,0.0401053,-0.016359001,-0.04859985,0.09033932,-0.0015525303,-0.013441814,0.023712823,0.0015448421,-0.028160645,0.030612601,0.06715095,0.028904522,-0.02297321,0.0357661,0.06723575,0.05515145,-0.08456924,0.030930473,-0.029853681,-0.02547333,0.008048968,0.057439387,-0.03507718,0.037621994,-0.050757527,0.035601217,-0.01464823,0.0576873,0.014783549,0.069412954,0.01726758,0.09810155,0.048779752,0.008580053,-0.07924346,-0.06809639,0.048257105,0.022726156,0.035380304,0.02883612,0.031577434,0.066463515,0.044475336,0.0045979004,-0.00836015,0.07007377,-0.057619065,-0.13378221,0.06381546,-0.02084662,0.028625602,-0.026526613,-0.033394683,0.09025483,0.021047615,0.00987557,0.091467984,-0.1308453,0.05364832,0.11320996,0.003582478,-0.07224548,-0.09526531,-0.0028245957,0.05862849,-0.062131733,-0.049423974,0.017107693,0.056809112,-0.035410035,0.008406172,-0.05533897,0.009748896,0.046026167,-0.00027404507,0.05648089,-0.041651417,0.0071425657,0.033671025,0.09719432,0.082139164,-3.5491386e-08,0.027459856,-0.066176,0.037432414,-0.00946853,0.015310203,0.058152568,-0.024706582,0.07854221,-0.013158208,-0.03427753,-0.014867095,0.10581828,-0.017749172,-0.008711438,-0.010508079,0.07716107,-0.017595802,-0.008249454,-0.04156012,-0.0037354087,-0.080640115,-0.009397423,-0.073901474,-0.06906497,-0.05178707,-0.06849824,0.021578213,0.07412558,-0.054539654,-0.07126514,-0.0087388195,0.0063969935,-0.023872769,-0.058483813,-0.041459292,-0.027605424,0.011465206,-0.07732743,0.014999347,0.034497872,-0.03262185,-0.024152275,-0.054673877,0.022371432,0.03786346,0.024057869,0.0026812025,-0.02550334,-0.032993633,0.021587262,0.046292063,-0.048543327,0.014835334,-0.05484181,-0.06481628,0.00788197,-0.091535404,-0.066452205,0.009671543,-0.05090686,0.010539789,0.05153491,0.1612421,0.012750046 +2.3.3.1,"The stereospecificity of this enzyme is opposite to that of EC 2.3.3.3, citrate (Re)-synthase, which is found in some anaerobes. Citrate synthase for which the stereospecificity with respect to C-2 of oxaloacetate has not been established are included in EC 2.3.3.16, citrate synthase (unknown stereospecificity). ",384,1.0,-0.049986843,-0.05066861,-0.10046863,-0.05092922,0.028026026,0.026844956,-0.08397324,0.0720221,0.02865974,-0.02370954,0.019240823,-0.16353227,-0.033748824,-0.0140267275,-0.049743578,-0.011000028,-0.016669922,0.023345254,0.037526794,-0.03271458,0.03847452,-0.011710924,-0.0036960822,0.013931014,0.011976337,0.02129688,0.008047678,-0.0016914685,-0.04468134,-0.123841666,-0.035877265,0.020897951,0.0063042305,-0.08225298,0.046672057,0.012835166,-0.07726624,-0.09740279,0.049399436,-0.0023806388,-0.011667451,0.038408805,-0.015841953,-0.0315882,0.026004817,-0.008335137,-0.018344613,-0.02149205,-0.015252315,-0.034063514,-0.06197331,-0.08963487,-0.05703525,0.062748104,0.008063439,-0.0014562986,-0.0026181603,-0.003426291,0.032316916,0.024245227,0.10156502,0.05789061,0.07969047,-0.0077680727,-0.015284,-0.032303773,0.058322337,-0.08602794,0.00011933926,-0.03013358,-0.0730725,-0.06547163,-0.03001487,-0.001732287,0.060585916,0.05800847,-0.0011223408,-0.033999063,-0.025512103,-0.02318776,0.0556672,0.057155594,-0.061185066,-0.022885319,0.0062124687,-0.039098922,0.007739181,-0.026576063,0.012542216,0.00942855,-0.02120049,0.008652588,-0.01948193,-0.022597307,0.033867095,0.039014287,-0.017081385,0.102669686,0.06539547,-0.051142093,0.032401036,0.0751662,-0.035974815,-0.03919393,-0.034627292,-0.03726729,0.013809519,0.05858191,0.0178533,0.007064702,-0.0024614984,-0.055770844,0.046725877,-0.012768381,0.010503484,0.16341329,0.046226844,-0.029667705,0.042286832,0.038341656,0.07547709,-0.00044811872,0.029051825,-0.0038038793,0.0106279515,0.0012338494,-0.10223381,2.6049462e-33,0.0037725184,0.05892637,0.032104444,0.017077083,0.025839843,-0.018446576,-0.13379356,0.035458058,-0.038297337,-0.0872461,-0.09695674,-0.02096799,0.0018347199,0.03928954,-0.06990202,-0.04138817,0.02366982,0.029659875,-0.049215555,-0.02945198,-0.00021719489,0.06389966,-0.046491306,-0.016320655,0.034114227,0.021427087,-0.028612133,-0.0049569216,0.05918949,-0.022799764,0.017956166,-0.022041371,-0.042954147,0.035248216,0.03536631,-0.042078953,-0.0036963848,-0.016750356,-0.034445085,0.09540956,0.07341527,0.0812291,-0.0057433434,-0.08670353,0.17245129,-0.07567007,-0.032180473,0.09449193,0.05047707,0.0032989979,0.015636478,0.028883617,0.040271994,0.0024522673,-0.020203523,0.024390595,-0.03585992,0.045744598,0.054967195,0.004056231,0.0016247871,0.12167677,-0.04906111,-0.024002979,-0.04432502,0.038470455,-0.12132974,-0.023677958,-0.0012498877,0.06746349,-0.046365034,-0.03264948,-0.015434514,0.061688915,0.098685585,-0.10569176,-0.112683885,-0.0061407415,0.03869784,-0.035441805,-0.02845334,0.04311414,0.012766437,-0.031187419,-0.056916393,-0.076135494,-0.038785882,0.018633923,0.008256792,0.09176412,0.05562741,0.0007283118,-0.17728615,0.029069453,0.014032676,-4.8192737e-33,0.05286455,-0.049077444,0.03758091,-0.06027539,-0.08912003,0.066108376,0.006033908,-0.0011746641,0.032338664,-0.050076056,0.09712809,-0.04167361,0.07613076,-0.07560122,0.04368116,-0.032608833,-0.018105768,0.039605148,-0.014575247,0.06096855,0.05045796,-0.034828465,-0.010353706,0.0014224519,-0.009695767,0.06077251,-0.031700652,0.08056995,0.06533784,-0.002770885,-0.03823987,-0.02324207,-0.0667135,-0.06520203,-0.0343755,-0.0017216878,-0.043222923,0.0011017562,-0.031593643,0.039343953,-0.0289683,0.080774814,0.00570916,0.05523894,0.056763683,0.043945022,-0.0036047508,0.007336424,0.013557243,-0.043759182,0.014187672,-0.01817586,-0.0014075509,-0.035171557,0.0102137,0.019939987,-0.05835022,0.030631999,0.022585828,0.007614321,0.012145636,-0.041435763,0.012856135,-0.03886689,0.06238843,0.04576462,-0.041836485,0.09944208,0.08252042,0.011140928,0.07793341,0.024990449,-0.0846298,-0.10316735,-0.033596404,-0.059485417,-0.07665946,-0.011454282,0.04571029,-0.0648351,0.01777342,-0.009774083,0.08608872,-0.06320568,-0.010142771,-0.031942777,-0.029941497,0.0804387,0.0038220368,0.0387083,-0.0254543,-0.043841474,-0.11856777,0.05881927,0.08289379,-4.0552123e-08,0.06221554,-0.04495928,0.09452148,0.022939438,0.025389617,0.012223604,0.012480391,0.0009838868,0.0011680198,0.0037633525,-0.06501549,0.013540703,0.058562826,-0.026997317,0.05356876,0.089212514,0.0013563705,0.03073354,0.009770908,0.058618914,-0.044194058,-0.026543036,-0.07708521,0.022183733,-0.025120912,-0.019222884,0.033509396,0.009920495,-0.049308006,0.0033309706,-0.0065251435,0.0396283,0.050249994,-0.053318314,-0.08394837,-0.054849587,-0.010257112,-0.028776981,-0.06228453,-0.06656901,0.03282089,-0.0076992027,-0.100239076,0.004996198,0.08786162,-0.02278296,0.04570876,0.0053074746,-0.052152134,-0.094308265,0.0338749,-0.019833678,0.003260724,-0.0027591763,-0.03284261,0.0033950154,-0.0014314465,-0.01983941,-0.041397694,-0.0066002724,0.00910065,-0.012002081,0.1847116,0.013669911 +2.3.3.16,"This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C-2 of oxaloacetate has not been established [cf. EC 2.3.3.1, citrate (Si)-synthase and EC 2.3.3.3, citrate (Re)-synthase].",384,1.0,-0.066006705,-0.07815817,-0.08081879,-0.0431992,0.012902622,0.0528206,-0.07591528,0.080823936,0.016542926,-0.043757275,0.016154401,-0.1707125,-0.036004752,-0.016286796,-0.04681708,0.011648592,-0.055330645,0.058204014,0.047196537,-0.020538414,-0.0013158413,-0.030111056,0.012194865,0.021676637,0.0012899044,0.04679524,-0.01825984,0.011834935,-0.006476029,-0.112538256,-0.06458613,0.03259089,-0.0108533995,-0.068827555,0.029261513,-0.0142126195,-0.08544309,-0.08911878,0.02841283,-0.008875163,0.0036897773,0.029315164,0.033712145,0.004373023,0.015362711,-0.020415086,-0.030691162,-0.043719206,-0.07150115,-0.007954141,-0.054095585,-0.06394618,-0.05334088,0.10408068,0.0064916685,1.3020601e-05,-0.010244662,0.045868844,0.062295504,0.009948977,0.07908457,0.060368292,0.057002164,-0.0073365583,-0.026781715,-0.00787197,0.03292895,-0.035892356,-0.01727817,-0.024383979,-0.08038448,-0.045810133,0.0024564934,0.00037871,0.045229085,0.08951732,-0.0041989735,-0.039733335,-0.027748384,-0.008820749,0.05273931,0.07780495,-0.053276416,-0.042843897,0.00945415,-0.0012901083,-0.038092412,-0.01749784,-0.02374603,0.0037531247,-0.020211788,0.009443471,-0.02006684,-0.010226884,0.01816272,0.045901082,0.025568202,0.101572305,0.052349366,-0.045669783,0.037322436,0.064755596,-0.03608894,-0.058413807,-0.054465353,-0.028402733,-0.016552683,0.051795706,0.002751788,0.03560679,-0.009560459,-0.044165056,0.036814123,-0.019116791,0.009685464,0.1518695,0.042479295,-0.0041641584,0.072311066,0.005560709,0.031534187,-0.0075499928,-0.027883325,-0.030606614,-0.028168594,-0.04294596,-0.076567754,2.0585112e-33,0.021783527,0.07281656,0.049247112,0.05870246,0.038657684,-0.061116673,-0.13448331,0.0022791654,-0.05377699,-0.099469684,-0.08399814,-0.030668778,-0.0121204695,0.045406114,-0.062231354,-0.049690947,0.035096135,0.009305853,-0.027663378,-0.078676045,0.018968107,0.097000994,-0.027295899,-0.0029549827,0.021866342,0.0325713,-0.021322088,0.015204084,0.055743195,-0.028028633,0.0007192179,0.0072459,-0.03416682,0.013571273,0.0731552,-0.043829024,-0.03113589,-0.027250918,-0.0008499466,0.08986341,0.09847272,0.070047446,-0.0122222,-0.07184169,0.14068535,-0.07309289,-0.025891962,0.09596406,0.034809634,-0.004680886,0.0023648345,0.035474334,-0.021175884,0.014314884,-0.018599048,0.010921878,-0.025064118,0.005473153,0.0470779,0.0056405463,-0.010090666,0.110175304,-0.019614913,-0.04780792,-0.03979181,0.04871031,-0.15296113,-0.012825132,-0.02443725,0.034580015,-0.02884317,-0.079557106,-0.0070108683,0.038746692,0.102915555,-0.047524124,-0.11197721,0.011560915,0.06495389,-0.05466642,-0.0063503645,0.0458119,-0.034328904,0.012436152,-0.032267183,-0.07524253,-0.04059846,-0.0014593189,-0.016837623,0.08084055,0.038342826,-0.012589972,-0.13546169,-0.010629863,-0.023032052,-4.6273034e-33,0.03643332,-0.03188202,0.052993342,-0.07587772,-0.07400795,0.04105833,0.0019199101,-0.058371,0.05562244,-0.04248794,0.11190991,-0.005797856,0.047329113,-0.07398505,0.015208681,-0.06573042,-0.0005860401,0.05159407,0.0037226325,0.07487142,0.088309295,-0.06157595,-0.05764373,0.031150967,-0.028707357,0.0632555,-0.011326379,0.049463898,0.080941215,0.03532977,-0.033510484,-0.051595315,-0.070439525,-0.06264175,-0.02361242,-0.025684575,-0.010395943,0.015185021,-0.064779475,0.02568403,-0.018019749,0.053974465,0.0076361066,0.08644269,0.065746464,0.030772211,0.005524911,-0.013421148,-0.031674407,-0.0097745,0.03580536,-0.019698823,-0.028844094,-0.062430266,0.018025512,0.020428274,-0.038447764,0.009783712,0.035341553,-0.032307494,-0.009852544,-0.03724407,-0.006548153,-0.06928441,0.049717773,0.050842106,-0.024123754,0.123237394,0.08550025,-0.010973076,0.09743725,0.052814342,-0.038001347,-0.105836,-0.04164316,-0.10012687,-0.056429386,-0.025136052,0.050066467,-0.028137075,-0.020952433,-0.0068842415,0.10008155,-0.050207533,0.030618494,0.00956995,-0.011152599,0.06564662,0.026107818,0.07330233,-0.012881351,-0.0068455953,-0.065917194,0.100732386,0.06464802,-4.0491017e-08,0.03662651,0.0022620454,0.065596595,0.035312813,-0.01894039,0.0101487115,-0.00065962697,-0.009550367,-0.008364729,0.0134432195,-0.055712607,0.030199053,0.08505351,-0.0371667,0.04171164,0.06361379,0.013029673,0.03410546,-0.0034727172,0.05816531,-0.034820653,-0.00039013004,-0.022090131,0.02348669,-0.019544821,-0.028830757,0.038264588,-0.024010621,-0.040184736,0.04693458,0.001458552,0.02589554,0.050347336,-0.080710106,-0.029670846,-0.07625339,0.017392183,-0.06222935,-0.068222426,-0.112200856,0.029428074,0.0005154377,-0.079491556,0.044095404,0.10899792,-0.02770451,0.027066808,0.02691534,-0.06385779,-0.08695173,0.023243442,-0.004260283,-0.021980805,-0.013034968,-0.031725086,0.027001547,-0.009220688,0.026690684,-0.03791651,-0.060488634,-0.0108487895,-0.024716921,0.15963098,0.024843533 +2.3.3.3,"This enzyme is inactivated by oxygen and is found in some anaerobes. Its stereospecificity is opposite to that of EC 2.3.3.1, citrate (Si)-synthase.",384,1.0,-0.012335312,-0.040429894,-0.088860475,0.011680101,0.07991098,-0.015313481,-0.0012404525,0.02607712,0.05779238,-0.03035107,0.053346384,-0.082882285,-0.023703286,-0.023184845,-0.063376576,0.020851366,-0.055209942,-0.02718746,-0.016673153,-0.055720944,0.0505877,0.050020043,-0.027577793,-0.006915763,0.025267433,-0.01277267,0.041262,-0.04581624,-0.02511717,-0.10310942,-0.030205501,-0.022460688,0.07698867,-0.06772776,0.036186058,0.018811362,-0.07068779,-0.0988569,0.005628206,0.014815651,0.02514658,0.014340402,-0.042116433,-0.04153912,-0.02006023,-0.015799755,-0.037299667,-0.038555272,0.006839814,-0.008865749,-0.07368667,-0.088191986,-0.036726363,0.07752959,-0.024236076,-0.024338143,-0.034904227,0.00865477,-0.020346938,0.017514434,0.07758766,0.04717734,0.034565765,-0.011647306,0.021812316,-0.04459429,0.123640485,-0.10971087,-0.0037788108,-0.038053047,-0.05839524,-0.08976299,-0.031571683,0.026294244,0.050107334,0.05767743,0.03623521,-0.05489401,0.036886934,0.021580957,0.011340741,0.04508015,-0.018898197,-0.0034957405,0.022945277,0.012743485,-0.0038662616,0.026854856,-0.0052706846,-0.012077212,-0.018863583,0.03232405,-0.04806315,-0.03972521,0.050787143,0.014928739,0.0016034448,0.0846699,0.03021022,-0.053003024,0.005630818,0.112492144,-0.109157085,-0.052571706,-0.065393776,0.013171071,0.055978198,0.07197002,0.027230948,0.0018592285,0.002754161,-0.053276252,0.07654476,0.010939753,0.029025218,0.18037005,0.05089025,-0.019126182,0.008494769,0.046283856,0.03435438,-0.019583274,0.017157175,0.013666207,-0.051076934,0.04851549,-0.09856646,-2.1479046e-33,0.00036450918,0.0175423,0.017621463,0.035990108,-0.0016611421,-0.0041871504,-0.106146015,0.021116527,-0.058313403,-0.09333755,-0.08308463,-0.056298416,0.007168413,0.042644653,-0.037673246,-0.045522247,0.07197345,-0.010974654,0.01743371,-0.03439008,0.062190782,0.04134226,-0.082449794,-0.0011659135,0.0514745,0.06588417,-0.04926517,0.011485704,0.0024739977,-0.010365572,0.0128800655,-0.044263307,-0.09161048,0.017557755,0.028276943,-0.02704209,-0.002194403,0.017970847,-0.045223836,0.106434196,0.019781474,0.079202674,0.0016615507,-0.05889822,0.12697215,-0.05887833,-0.03323014,0.09397333,0.12461317,-0.010723044,0.03858702,-0.01895479,0.07188745,-0.056157414,-0.023086417,0.037297096,-0.008061148,-0.0039019033,0.0077386624,-0.0033051309,0.038584355,0.07706247,-0.058014933,0.065686874,-0.005186163,0.059506997,-0.10971415,-0.01712879,0.0043996335,0.055969454,-0.10524024,-0.012791254,-0.003928476,0.020162355,0.018837972,-0.10730781,-0.12982902,-0.012479548,0.038420953,0.010608679,0.035072286,-0.025669765,-0.006210507,-0.04329513,-0.04187762,-0.07325077,-0.050743937,0.052188564,-0.002391814,0.05996857,0.061821092,-0.04091114,-0.14373921,0.0023873148,-0.0029335453,-1.0557331e-33,0.07472263,-0.05882802,0.027320178,-0.04515529,-0.08186621,0.14335483,0.001883586,0.0045143967,0.031823367,-0.03830948,0.07358673,-0.030801287,0.05917783,-0.07390337,0.04016381,0.027326722,-0.029686652,0.033835497,-0.027031265,0.024216803,0.01602116,-0.010572964,0.0062441006,-0.016151192,0.0029328591,0.022879615,-0.0481919,0.10992146,0.020318476,-0.0070250174,-0.02312418,-0.04182511,-0.033210997,-0.08281612,-0.035323538,0.020623641,-0.040118996,-0.016999586,-0.016727563,-0.002024863,-0.034765996,0.05227044,0.039665136,0.09510331,0.059688125,0.09100206,-0.026476601,-0.019448651,-0.028768891,-0.03424034,0.015566934,-0.0024437844,-0.039790597,-0.007888376,0.0311824,0.034158785,-0.053893,0.052541237,-0.040977944,-0.002569599,0.008920811,-0.025592184,0.029756196,0.0004909821,0.026289925,0.064070836,-0.0053534764,0.15029271,0.048433486,-0.027499313,0.07650506,0.04289397,-0.06795379,-0.05328811,-0.09346851,-0.029622719,-0.064616315,-0.009408129,0.05017831,-0.042705756,0.00061034446,-0.008974164,0.023676343,-0.08977903,0.006453788,-0.043371983,-0.00027178822,0.09981977,0.015019437,0.03521097,-0.05768411,-0.038214903,-0.102193095,0.0038179494,0.044397064,-3.4064875e-08,0.047784988,-0.06655184,0.059680812,-0.024557475,-0.0014988967,0.034157243,0.04018112,0.015147005,0.02989654,0.019054823,-0.0778816,0.009143475,0.04215897,-0.03887681,0.104799725,0.03081247,0.02630544,0.024265014,0.013937493,0.020013308,-0.053073548,-0.036118127,-0.075610735,0.038679086,-0.0034777462,-0.014614783,0.032063223,0.046107996,-0.010547454,0.0030482174,-0.023219673,0.047136493,0.033759985,-0.043342154,-0.11814217,-0.013732615,0.02859958,-0.047172327,-0.047218125,-0.036676887,0.04844181,-0.0041592233,-0.08381545,-0.041400183,0.06774659,0.030222842,0.05828088,-0.027672974,-0.024483668,-0.049741194,0.017530588,-0.0535356,-0.019182663,0.04382876,-0.06759791,-0.017991291,-0.008539023,-0.017069265,-0.018776992,-0.038705196,0.026578872,-0.00080172817,0.19681855,-0.007898857 +2.3.3.4,"Decanoyl-CoA can act instead of dodecanoyl-CoA, but 2-oxoglutarate cannot be replaced by oxaloacetate or pyruvate.",384,1.0,-0.06143607,-0.052769784,-0.013647025,-0.026057418,0.02112257,-0.07060721,-0.09249373,0.005633463,-0.029404955,0.0195287,-0.014272688,0.00046681787,-0.08674668,0.09572478,0.03368237,0.009552177,0.0053813253,0.014312284,0.06609199,0.11105297,0.07225765,0.017026987,-0.045386717,0.006438921,0.06526751,0.01811527,-0.039204195,0.026712991,-0.025917543,-0.14049013,-0.0016221242,-0.0017844388,-0.025584877,-0.04895264,0.024562236,0.031082802,-0.0545917,0.023253648,0.02754559,0.020546086,0.035830863,-0.03683251,-0.057442147,-0.020799827,0.014314502,-0.06158013,-0.025470871,-0.015676409,-0.020309305,0.0705725,-0.015024712,0.019637497,-0.09939887,0.08856502,0.0069365674,-0.027730145,-0.02066128,0.05856398,-0.08823015,-0.04102253,0.01804795,0.023025295,-0.02290088,0.015410284,0.007602414,-0.031160457,0.029259974,-0.021278419,0.06248531,0.009359119,-0.07215947,-0.05611058,0.08759023,-0.03986753,0.014006606,0.00015011818,0.022114947,-0.008259389,0.033047736,0.026006918,0.020857971,0.09612297,0.02834161,0.013203089,0.038473062,0.05261114,-0.05960536,-0.067182705,-0.024591547,-0.026933428,0.008512482,0.040661376,0.072066635,0.0028456056,-0.032668117,0.050409146,0.054344963,0.047380805,0.03824655,0.01743992,-0.039255857,0.07183633,-0.06937526,-0.11999558,-0.043780383,-0.017776204,-0.042027347,0.011903231,0.041731473,-0.0025939606,0.015543845,0.06846176,0.050698712,0.06384273,0.020955449,0.050759435,-0.028892534,-0.02389358,-0.04727839,0.043293126,-0.0009639691,-0.057025377,0.037580386,-0.00024286813,-0.027802408,-0.029196529,0.012355804,3.8754385e-33,0.034376223,-0.035571042,0.040378403,0.00015103522,0.05012393,-0.009621584,-0.060624935,0.00418292,0.011280761,-0.039389536,-0.035154864,-0.040934205,0.018406978,0.022663753,-0.0550575,-0.011777469,-0.024043232,-0.02929203,0.057076443,-0.0427207,0.045647934,0.102934994,-0.019935891,-0.032829218,0.018366287,0.033273745,-0.03406186,0.078841425,0.013068794,0.009758468,0.013038143,-0.07186921,-0.0016084753,0.055753373,-0.021255273,-0.07784666,-0.12363864,-0.05275009,-0.035085984,-0.0018863955,-0.0011817338,0.047916144,-0.059330627,-0.0031454742,0.044594858,-0.060469177,0.07987171,0.09902131,-0.06488549,-0.023848368,0.02882688,0.03488828,-0.011270665,-0.09220886,0.007832007,-0.007321265,0.022664508,-0.0067808316,0.10988925,-0.015027529,0.05538933,0.0236861,-0.0122174155,-0.01827061,0.00030581176,0.02863245,-0.04917269,0.053004276,-0.013978608,0.0030802186,-0.00948463,-0.07188931,-0.016428959,0.05169394,0.03943893,-0.07356108,0.0363048,0.094111785,0.07795651,-0.04075578,0.048620902,-0.053148348,-0.0072128708,-0.0020478629,0.0004778849,0.018828994,0.012297843,-0.0036917143,0.034801066,0.089899816,0.030528842,-0.021300148,0.005820912,-0.073239304,0.113824576,-5.1980753e-33,0.10271172,-0.12848257,-0.03423299,-0.05658557,-0.07372505,0.04860333,0.0027338292,-0.055086803,0.057105254,0.014159438,0.05512774,-0.009255506,-0.013338465,-0.05040741,0.015154768,0.064543836,-0.009948077,0.013975916,-0.050667185,0.0066678342,0.04435316,0.09364033,-0.06515361,0.006061302,0.05431181,0.018560717,-0.022593828,0.047675557,0.0824928,-0.021223841,-0.054586444,-0.04925359,-0.038077142,-0.013025075,0.0034415335,-0.024474438,-0.057967555,0.016868593,-0.10638952,0.0037139656,-0.012974606,0.00858595,0.057649445,0.049985405,0.077674046,-0.044959933,-0.10699458,-0.11700638,0.02146126,-0.01463121,0.049083814,0.015805092,-0.091289036,-0.028462267,0.046866175,0.0977171,0.006629187,-0.039156597,0.06757029,-0.0555972,-0.049447373,-0.0897995,-0.037104562,-0.07472019,0.116252676,0.06805947,-0.06671203,0.03227019,0.04502852,0.012313958,0.11593762,0.01539678,-0.0014649705,-0.10789184,-0.017208021,-0.09759827,-0.07055544,-0.034221653,-0.061777506,-0.058944073,-0.025702734,-0.030481486,0.027799724,-0.071575396,-0.022179902,0.006766113,-0.0082582,0.07114876,-0.054862183,0.00079257716,0.0324371,-0.029324327,0.05788675,0.027338412,0.08399652,-2.9624227e-08,-0.029337985,-0.00406105,0.07642969,0.05140353,-0.014733892,-0.048220735,-0.03980481,0.014374667,0.0044576353,-0.009795184,0.027457608,0.099970825,0.11567824,-0.013817787,0.035306334,-0.028071305,0.015007852,0.011386994,-0.024723303,-0.038545564,-0.08735741,-0.016482014,-0.0733379,0.09701927,0.0017267587,0.00469231,0.028952448,0.017955905,-0.010700165,-0.051449317,-0.013596283,0.01697628,0.042462256,0.02869565,-0.028520245,-0.08210013,0.070935234,-0.044530015,-0.083283685,-0.024569957,0.012323641,-0.03648186,-0.017710837,0.09157349,0.022866167,-0.03006979,0.04600348,-0.053361207,-0.043986857,-0.011394016,0.11292971,0.041405622,-0.06548266,-0.034711733,-0.055091828,0.017966488,0.02794092,-0.012114845,-0.07586337,0.008679094,0.060839232,-0.052715182,0.21153542,-0.07278088 +2.3.3.5,"The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1, citrate (Si)-synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.",384,1.0,-0.082665324,-0.058550406,-0.07467633,0.0056141578,0.07554174,0.002971646,-0.14972106,0.06591742,0.047812626,-0.04538546,0.030968726,-0.0568368,-0.10126642,0.010177847,-0.022904329,0.009705016,-0.030119006,-0.039096512,-0.0063208113,-0.05705778,0.07214036,-0.031221217,-0.048376124,0.006109095,0.09950319,0.022929065,0.013044314,-0.009018594,0.034564342,-0.09034656,-0.08987152,-0.049044922,0.023395957,-0.022776395,0.06975233,0.018393263,-0.06884869,-0.09185875,-0.01905701,-0.0011779324,0.07104854,-0.0002879065,-0.077317305,-0.031444337,0.012030259,-0.011555829,0.007219285,0.022084806,-0.019812696,0.03564052,-0.040027536,-0.04966799,-0.037100647,0.049806107,-0.021515748,-0.018757494,0.021349084,-0.008172412,-0.020887285,0.00306321,0.051334184,0.06769889,-0.040053092,0.009918179,0.0045483103,-0.029922148,0.089454815,-0.034388028,0.0032215347,-0.039853655,-0.10513314,-0.03696572,0.029979449,0.035641946,0.04307385,-0.038041793,0.0028503416,-0.031674262,0.043517526,0.013704607,0.042127367,0.017936515,-0.034286987,-0.016823173,0.004613983,0.009083678,0.0039288015,-0.0178064,0.0088155195,-0.021453157,-0.017018363,0.027022025,-0.03803761,-0.04413691,-0.018004104,0.100490935,0.03490484,0.01938196,0.03005032,-0.0023703063,-0.027832909,0.12955903,-0.026802935,-0.10833035,-0.045834903,0.025138976,0.0074857455,0.073106766,0.06702018,0.080631964,-0.023290878,-0.03468699,0.09397672,0.024664136,0.014388513,0.08649359,-0.023178784,-0.017972391,0.02586938,0.03785216,0.05231046,-0.01787566,0.058340885,0.047013555,-0.014092169,0.042470668,-0.047285654,3.847256e-33,0.063932225,0.01015152,0.009852101,0.0081109805,-0.0023488032,-0.035546683,-0.09193067,0.03498116,-0.027608972,-0.067117214,-0.007257308,-0.06647822,0.0054057273,0.023182046,-0.0149745075,-0.074273765,0.04091048,-0.02040259,0.044075865,-0.012007173,0.00944678,0.028886583,-0.058684528,0.054336805,0.039002307,0.016013157,-0.041705083,0.10301948,-0.011599889,-0.025429435,0.05249702,-0.049131054,-0.08097688,0.0013139506,0.036341824,-0.06775561,-0.07568401,-0.02743186,0.016328884,0.110859014,0.042875897,0.058047365,0.0055427197,-0.02832405,0.030139124,-0.0779895,-0.020714354,0.11342562,0.028347505,-0.038049415,0.033209223,-0.00031423944,0.019254062,-0.05598855,0.03158075,0.070125274,-0.0017017104,-0.008816605,0.081293546,-0.0154160345,0.028836718,0.059531927,0.0075298166,0.03673536,-0.024301449,0.024245944,-0.1501821,0.037811514,0.008547477,0.061962504,-0.073831,-0.024593212,0.019216519,0.016737336,0.039970517,-0.12853967,-0.0346558,0.034509223,0.018814065,-0.06085309,0.002827348,-0.011271675,0.008171748,-0.021922525,-0.0845756,-0.043223508,-0.010857183,0.037860252,0.026558623,0.07953489,0.042005014,-0.038827658,-0.011195142,-0.012243695,0.060648803,-5.148677e-33,0.1094972,-0.098585695,0.05336222,-0.07038448,-0.077973954,0.081077285,0.039235912,-0.025594346,0.018095288,0.010523443,0.07898862,0.027390046,0.02058762,-0.062705725,0.060612373,0.08992527,0.003257712,0.016272996,-0.006140669,0.021381848,0.04092697,0.021000693,0.005919366,-0.015664252,0.023612576,-0.01645311,-0.024533005,0.06393204,0.019846603,0.018518338,-0.03372732,-0.056040373,-0.054422554,-0.024245374,-0.058780175,-0.00867611,-0.020430313,-0.00397618,-0.061137192,-0.025442192,0.01195289,0.04607345,-0.014255966,0.030865626,0.07612261,0.069760464,-0.039252598,-0.11717391,-0.022313545,-0.05881709,0.052939586,0.030641815,-0.04731751,0.059509408,0.013185126,0.08584983,-0.043204747,-0.045546543,0.004514319,-0.054213762,-0.06309016,-0.09288672,0.00718791,-0.047582317,0.113069676,0.012162999,-0.04690834,0.09391274,0.098161936,0.014192879,0.102185406,0.0105098635,0.025013827,-0.041123625,-0.039184242,-0.063708775,-0.01789949,0.0019118434,-0.054415256,-0.10041233,-0.01180587,-0.017327346,-0.038792644,-0.10938103,-0.107184835,-0.019280246,0.044315483,0.092979506,0.0026551231,0.053752527,-0.056421492,-0.008622975,-0.031822808,-0.0023441473,0.071660265,-4.5977437e-08,-0.029970318,-0.04952417,0.11451774,0.04037636,0.010382224,0.01749514,0.05358069,-0.00049614947,0.030681312,0.0177263,-0.046576336,0.088377595,0.07629724,-0.056290377,0.035679627,-0.022237858,0.028084232,0.07110393,-0.002694829,-0.010299785,-0.060823705,-0.0018864356,-0.07193191,0.056579307,7.171081e-05,-0.00960879,0.06106756,0.05597037,-0.05845237,0.018393295,-0.06311138,0.043309458,0.05391173,-0.07763992,-0.055067852,-0.044510793,0.062353652,-0.020272234,-0.076814175,-0.00690383,0.045274787,-0.017338991,-0.10689994,0.0126612345,0.06826065,-0.010101021,0.056693573,-0.021410935,0.00059632974,-0.058716588,0.06503806,-0.00822552,-0.07215926,0.019390011,-0.016219571,-0.015666159,0.0015063975,-0.019412601,-0.0682495,-0.014909032,0.031599857,-0.020388415,0.1935993,-0.03627623 +2.3.3.6,Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 2.3.3.7 3-ethylmalate synthase.,384,0.99999994,-0.017217647,-0.1054732,0.012248075,0.013330564,0.10606583,0.11725617,-0.018815737,0.026724659,0.04207149,0.008460905,0.044671502,-0.03159021,-0.055602625,0.0033983695,0.02043134,0.04890434,-0.06308497,-0.028308772,-0.014595979,-0.07857144,-0.0064645587,0.09230383,0.048584,0.026646707,0.05683907,-0.009546644,0.04150154,0.0024964476,0.030268377,-0.11271205,0.02120847,-0.0017809652,0.008699051,-0.023465734,0.0064752437,-0.018470272,-0.052304145,-0.067822,0.016716586,0.015923627,0.08738842,-0.032304935,-0.012338403,-0.06625316,0.0018890119,-0.01895132,-0.017052364,-0.006585685,0.02495769,0.0020414323,-0.06505068,-0.12965569,0.00055242376,0.043505,0.01981377,-0.002912567,-0.08450311,-0.0484006,0.011059696,-0.019958725,0.05383499,0.03096407,0.013071588,-0.04262958,-0.034778606,0.00012353258,0.0700175,-0.09466928,0.045252416,-0.033100285,-0.0769825,-0.12146015,-0.013977805,0.026452877,0.006875538,0.012185439,0.02964536,-0.069951184,-0.014488422,-0.040962014,-0.021768859,-0.00035267734,-0.012395645,-0.047586262,0.0025060107,0.012159492,0.018599775,0.044120815,0.033434007,-0.012298763,0.04782555,-0.06512881,0.041808758,0.058244415,-0.027321117,0.026128996,0.0036257454,0.05358136,0.04888075,-0.010491881,-0.049270757,0.051569868,-0.027510436,-0.04367048,-0.1022693,0.011421715,-0.00066463836,-0.0050753956,-0.026351731,-0.04642571,0.009102152,-0.07299521,0.015320877,0.05508459,-0.09088711,0.08409469,0.0053127455,-0.03563223,-0.015620567,0.004766168,0.02487585,-0.011688275,-0.0065805735,0.06924867,-0.06886465,0.05683279,-0.14488468,-8.790464e-34,0.0790357,0.056350492,0.023779389,0.011451914,0.053673092,0.015627237,-0.11669873,0.017217552,-0.0034007207,-0.07975345,-0.0405831,-0.072212264,0.020812118,0.021065349,-0.013321865,-0.0010576565,0.07963417,0.03494615,0.0035242664,-0.05845687,-0.022575356,0.06635672,-0.07539621,-0.041888542,-0.029466402,0.022617705,0.04145311,0.0031882594,0.14749964,-0.022714648,0.011795667,-0.055701323,0.006791154,0.09054169,0.007346388,0.027756907,-0.039236423,-0.054483164,-0.008374572,0.039659202,0.06820531,0.07711125,-0.003710704,0.0027324054,0.02304565,-0.09965122,-0.10270597,0.094663866,0.08189113,0.070502914,0.056354705,0.009981812,0.12631941,0.0063484353,0.0030810162,0.029115956,-0.08299254,0.008487618,0.07228763,-0.0068683787,-0.027022406,0.025953475,0.005200067,-0.03792531,0.016779117,0.026210237,-0.07969098,-0.06189957,-0.059600845,0.031684183,-0.05815322,-0.0084558185,0.08704732,0.06837306,0.079154894,-0.053558744,-0.094798125,-0.0391123,0.0013877605,0.051475767,-0.08048121,0.05636111,0.012731856,0.010038831,-0.029117893,-0.09373896,-0.020958157,-0.0017163408,0.0049021305,0.07267888,0.09148901,-0.049711693,-0.1197773,0.07775987,-0.008239471,-1.4626564e-34,0.028571453,-0.06538618,-0.0050633727,0.030621275,-0.01654516,0.0092633385,-0.006927962,-0.014107058,0.05712761,-0.047521457,0.13365132,-0.0322172,0.06977888,-0.077337034,0.047039196,-0.047376648,0.030013587,0.054209787,-0.015787544,0.0099194925,0.032485463,0.018861191,0.0054642446,0.0556614,-0.006072238,0.030536903,0.03458456,0.05006123,0.007869224,0.05666079,-0.0013938537,0.03193595,-0.08617719,-0.08714741,-0.016890148,0.057606466,0.025085468,-0.009230174,-0.020906249,0.00360253,0.005578215,0.02749922,0.022857826,0.10212496,0.055281863,0.052254885,0.053422093,0.0097643845,0.005805402,-0.058983628,0.010434691,-0.05799557,0.021411765,-0.0105869975,0.061893106,0.06629603,0.019281762,0.027381726,0.0014038371,-0.05675916,0.015327891,-0.014538727,0.0030973647,-0.08258102,0.0060128476,0.023566766,-0.08128515,0.051912915,0.13112938,-0.02004001,0.056877308,0.028692706,-0.045926973,-0.0027032986,-0.061648175,-0.068982154,-0.05635705,-0.07840981,0.005887581,-0.060520966,0.036903474,-0.022700515,0.022755831,-0.04102276,-0.002325526,0.00333228,0.031395715,0.10437907,-0.01898557,0.015480052,-0.026521893,-0.008006647,-0.08255333,0.16226086,0.034540415,-3.1366792e-08,0.056795597,-0.044618387,0.04012113,-0.05853641,0.05386987,-0.021411398,0.044300415,0.034150265,0.005011818,-0.005954925,-0.07402225,0.009547848,0.016678741,-0.016028669,0.05706953,0.005146393,-0.020324413,0.12581329,-0.065355256,-0.04978781,-0.035355277,0.002460097,-0.01476061,-0.008977179,0.004661335,-0.032903504,0.048185915,0.058854915,-0.025370954,-0.08288065,0.05781081,0.015407655,-0.011099171,-0.05373967,-0.09161265,-0.023108235,0.023793213,-0.012046527,0.010156176,0.041004367,0.013501587,-0.0076039536,-0.07905575,0.033171788,0.016537307,-0.034621447,-0.0069604516,-0.020021752,-0.049785264,-0.09888922,0.084925376,-0.011249299,-0.014355515,-0.030486736,-0.08869032,0.014379286,-0.03293988,-0.016554298,0.044977088,-0.06442521,0.0032635918,-0.05782379,0.11993456,0.030781534 +2.3.3.8,"The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).",384,1.0,-0.043554816,-0.07305047,-0.019150585,-0.022479856,0.060944356,0.02178353,-0.096859716,0.06331866,0.06029592,-0.03227025,0.07236422,-0.06405254,-0.06449486,0.05017626,0.0043465574,-0.035411574,-0.09417077,-0.016061258,-0.08022904,-0.05912425,0.007571793,0.0076807938,-0.09353387,0.014810719,0.059564725,-0.007042485,0.067561366,-0.032057613,0.027489025,-0.098827995,0.022826105,-0.058366172,-0.027358094,-0.02549752,-0.022753222,0.048023194,-0.029524721,-0.13580695,-0.012389744,0.010247109,0.05370507,-0.036147665,-0.043618266,-0.055182,-0.049197827,-0.060398106,-0.021075731,0.026171852,0.034798186,0.024696514,-0.047298662,-0.09816015,-0.00824382,0.017257309,-0.028235264,0.0461964,-0.082422405,0.016534016,-0.011023989,0.07193019,0.010243576,0.09674685,0.0021223533,0.033370856,-0.018484151,-0.05630969,0.15065141,-0.055048726,0.031458687,-0.019306643,-0.0498628,-0.11011272,-0.004182885,-0.015403793,0.032728918,0.05020372,-0.02579807,-0.068280645,-0.010698771,0.06638202,-0.05519743,0.029878512,0.031760458,-0.021343756,-0.014886215,0.019460134,-0.02785858,-0.00953763,0.029839002,-0.023364507,0.059108894,0.050706424,-0.014104839,0.027384825,-0.009537916,0.07671284,-0.008158604,0.07591611,0.039188556,-0.015067941,-0.027197482,0.10823328,-0.09978827,-0.04996511,-0.054582927,-0.010081455,0.022611612,0.05428608,-0.018039359,0.006795797,0.010590677,-0.048687935,0.05206999,0.0060612843,0.01646688,0.064279966,0.008096013,-0.03094565,0.059831716,0.06765029,0.04448132,-0.028097708,0.064142,0.075978845,-0.03470403,0.04185144,-0.04767545,-2.0123938e-33,0.040016234,0.00550191,0.03313982,-0.0008477934,-0.024470333,0.0009911192,-0.1053952,0.10728682,-0.11434869,-0.05990793,-0.034276124,-0.021644603,-0.010236956,-0.010450321,0.021122487,-0.022330828,0.06480555,-0.005082207,0.015038599,0.051734045,0.07521327,0.07227824,-0.04442068,0.06827497,0.029022507,0.07695337,-0.030621553,0.050322745,0.022484927,0.020825636,-0.056788195,-0.0732741,-0.062424406,0.025529623,-0.00747646,0.0070184697,-0.055419818,0.02272235,-0.05569033,0.07210611,0.061331004,0.03899443,-0.012419527,-0.059122875,0.053125694,-0.049258027,-0.03098827,0.06483349,0.05080871,9.698343e-05,0.03900975,-0.009496464,0.12111932,-0.024454698,-0.04220461,0.057066713,-0.016292863,-0.0069915224,0.043263048,0.009092145,-0.016038872,0.098695934,-0.03586275,0.024998263,0.032056127,0.061654694,-0.0780458,-0.04563028,-0.032415934,-0.0108560575,-0.13300976,0.014169339,-0.004119995,-0.022554345,0.078405075,-0.14358574,-0.09605238,0.024966469,0.010404094,0.06685416,-0.035428453,0.021778477,0.021099957,-0.040427756,-0.006180992,-0.060126882,-0.0018374051,0.029755494,0.030932412,0.02158037,0.056277283,-0.055493757,-0.0017009812,0.0032181072,0.062127285,-1.01385065e-33,0.029406592,-0.07569144,0.030940648,-0.023749875,-0.06401012,0.08972312,0.05063474,-0.0010165959,0.029832494,-0.018455949,0.10777555,-0.02951867,-0.052718095,-0.06405015,-0.012774708,0.059073795,-0.052138004,0.03990731,-0.0038122141,0.029721376,-0.032670993,-0.0129885245,0.072494455,-0.039601807,0.13115802,-0.022795105,0.056040205,0.010553062,0.02647648,-0.019814193,-0.027088633,-0.024757527,-0.015655808,-0.024803853,-0.14261118,-0.008206807,-0.12407791,0.0051921993,0.027316917,-0.021849465,0.018069481,0.0723091,0.011833919,0.09763321,-0.014864789,0.05780698,-0.01923315,-0.032162018,0.0071068746,-0.06356477,-0.0068732877,0.017972847,-0.055031985,0.018824847,0.0018425673,0.04047856,0.07211058,0.04798274,-0.014108939,-0.041765243,-0.027480623,-0.05492596,-0.022583056,0.033658393,0.13417849,-0.014396105,-0.05087222,0.09993443,0.04390634,-0.044549894,0.07878532,-0.0078514945,0.015916679,-0.047423158,-0.010286832,-0.05862633,-0.084400885,-0.050337475,-0.02519127,-0.05936682,-0.00013043919,-0.024102565,-0.024255669,-0.08882719,0.015891146,-0.051644612,0.03703282,0.081018075,0.0068082805,0.043397166,-0.05401575,0.0368908,0.028784718,0.051052347,0.08135225,-3.7604792e-08,0.05679599,-0.06449143,-0.06434013,-0.029995441,0.035243336,0.028325377,-0.069542766,-0.003116609,0.026434004,0.080359206,-0.04885485,0.0454623,-0.014174569,-0.007563267,0.021153625,0.01521786,-0.023944383,0.057286106,0.03488656,0.04601206,-0.024958432,-0.022260074,-0.062193938,0.039692692,-0.0333953,-0.014531257,0.03367771,0.08625553,-0.035658434,0.011512767,-0.06631807,0.006470756,0.014856406,0.010610803,-0.07291974,-0.012173159,-0.031483967,-0.0022252575,-0.077443436,0.043664828,0.06048786,-0.054703582,-0.07623466,0.0025924714,0.0334913,-0.008913408,0.07985708,0.004759078,0.03323485,-0.012132852,0.020134484,-0.021678617,-0.053696834,-0.04385532,-0.025953578,-0.023189794,0.008893846,-0.058188207,-0.029212419,-0.059113327,0.02419439,-0.018285083,0.16916528,-0.035747763 +2.3.3.9,"The enzyme catalyses the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO2.",384,0.99999994,-0.10692515,-0.010489328,-0.024557622,0.05958309,0.08015001,0.085911386,-0.072097816,0.033973698,0.07822475,0.02556761,0.009428734,0.013724389,-0.02885793,-0.035666715,-0.04150062,-0.027086318,-0.042029303,-0.060933925,-0.01918019,-0.092893556,0.08784013,0.0067777783,-0.085108995,0.010953411,0.060458902,-0.0039941133,-0.005679892,-0.04601602,0.0220556,-0.06515219,-0.04934333,0.013577989,-0.061183486,0.012176751,0.012699231,0.06713465,0.0198921,-0.042955607,0.042684413,-0.019035809,0.0016805658,-0.015955163,-0.07436255,-0.06810408,-0.004402098,-0.04682068,0.024632402,-0.00805097,0.029947285,-0.030885508,-0.008919206,-0.032573204,-0.07682411,0.017904809,-0.007896872,0.05779234,-0.035250932,-0.052717183,0.018015727,0.034378383,0.04653613,0.0004262095,-0.018453764,0.059324846,0.08523369,-0.09022261,0.0537768,0.005466472,0.01381208,-0.04622174,-0.065881304,-0.040602013,-0.09438964,0.03161906,0.030646555,0.0160662,-0.056537103,-0.052660022,0.063885115,0.058796823,0.039251797,0.071407765,0.06108546,0.039297767,0.018746927,-0.005678071,0.029325837,-0.009727088,0.028007217,0.0020512221,-0.014332311,-0.023439998,0.020629194,-0.0049816133,-0.048122905,0.024498332,0.09914386,-0.0033668717,0.035992797,0.021701127,0.016031694,0.08271707,0.03645409,-0.12561351,-0.062048662,0.013352831,0.04158575,0.06119926,0.094445206,0.0017754782,-0.042442136,0.013062968,0.099089056,-0.009511881,-0.03157447,0.1234198,-0.008713483,-0.005594923,-0.017848447,0.019590821,0.04135509,0.015180874,0.026063357,0.076540425,0.038803827,0.050989203,-0.028456002,1.1326683e-33,0.10489326,0.047352258,0.07728316,0.036006153,0.0537366,-0.08499948,-0.11817382,-0.0050954176,-0.01749842,0.035882726,-0.007897847,-0.03918588,-0.0011590248,-0.0013110574,0.031419467,-0.048445694,-0.036392067,-0.03023806,0.06638451,-0.0019187726,-0.06485679,-0.011119657,0.023244195,0.008239421,0.044608165,0.04454978,-0.008159527,0.07857933,0.008970518,0.017575504,0.03030314,0.017416261,-0.08100379,0.04223309,0.029153563,-0.04947469,-0.08286123,-0.008988225,0.020984916,0.12354661,0.062479425,0.019593436,-0.025045082,-0.012758088,-0.003915085,-0.123814106,-0.039144684,0.09678894,0.02625163,0.04649462,0.03441566,0.00880438,0.01478195,0.03244739,-0.005504421,0.08956693,-0.012276273,-0.098243445,0.013834741,0.011343903,0.074519135,0.009775947,-0.03778229,0.009799378,-0.039463606,0.01538088,-0.087819554,-0.020540172,-0.002536728,0.04901507,-0.03945421,-0.026483726,0.05002421,0.06878971,0.046714645,-0.08631155,0.0046025068,-0.009598411,0.045776725,-0.028948937,-0.027376061,-0.0013553285,0.037170313,-0.040819712,-0.06620453,-0.08855102,0.021509841,-0.05129763,-0.017341878,0.0034372786,-0.008971585,-0.027424248,0.013568069,0.015384564,-0.0007026872,-2.3169282e-33,0.09559536,-0.11764783,-0.0002907228,-0.132975,-0.033484478,0.0021214935,0.020379571,-0.06576732,0.011575657,0.029900542,0.09989257,0.055091273,0.040601995,0.016136976,0.04037883,-0.012866541,0.030087765,-0.028429762,-0.03819008,-0.01402277,0.0023410008,0.054124765,0.035103153,-0.051288612,0.05303949,-0.017758714,-0.080240786,0.03952055,0.08556443,0.08754784,0.0054745353,-0.019119928,-0.03624197,-0.017776428,-0.06745656,0.050200205,-0.0032247787,0.035664886,-0.032159716,0.0020367827,0.0269075,0.01657541,0.0065480247,0.002585759,0.10880353,0.06529102,-0.02952837,-0.08912042,0.006931154,-0.09470973,0.06764473,0.030327324,-0.04857295,0.06556734,0.00472132,0.11654834,-0.0046203714,-0.0136353215,-0.012314309,-0.06542709,-0.03872827,-0.032745615,-0.010739942,-0.046704628,0.05186112,0.0105613135,-0.059655193,0.041853055,0.06495049,-0.02381551,0.07179643,0.020474747,0.009505343,0.0101317875,0.01444092,-0.022419332,-0.0962996,-0.028019862,-0.068649285,-0.08565626,-0.05735997,0.01650441,-0.06618546,-0.09163091,-0.09834887,-0.084112145,0.011766011,0.08762277,-0.010473281,0.034488536,-0.08131279,-0.04955343,-0.04190233,0.092558526,0.07199744,-3.5585142e-08,-0.05817349,-0.03392757,0.028920114,-0.0053310865,-0.02912749,0.03252771,0.07512664,-0.024131611,0.07262648,-0.07483511,-0.06529375,0.10106561,0.076374196,-0.014482152,-0.024330758,0.049372956,-0.07033378,0.06249819,-0.0072397734,-0.08019988,-0.038620666,-0.012220557,-0.038646642,0.04729304,-0.01760819,-0.050674178,0.04103397,0.08988578,-0.10376337,-0.008311488,-0.02409643,0.08426826,0.005098941,-0.031474583,-0.083691664,-0.010466085,0.017301371,-0.010846955,0.006594048,0.002170304,0.011025708,0.03530503,-0.11788451,0.0021570663,0.05250858,0.006248621,0.05774227,0.011921942,-0.00259416,-0.034495123,0.05665431,0.01080444,-0.07757294,-0.022443524,-0.0065010516,-0.028656904,0.011709966,-0.019312479,-0.040102616,-0.052971628,-0.04699945,0.016983138,0.1383159,-0.0911958 +2.3.3.13,Requires K+.,384,0.99999994,-0.011973202,0.043285,-0.0042351712,-0.014561461,-0.06611634,0.01375039,0.04314299,-0.086106256,-0.04198558,0.058892824,0.0015147821,-0.052170478,-0.009049526,0.038078316,-0.0017842386,-0.026045151,0.03373842,0.069880135,-0.0391223,-0.020913837,-0.014112076,-0.12790214,0.022661725,-0.034373,0.035906564,0.015405885,-0.0018822956,0.012303849,0.097200036,-0.022729209,-0.07337843,0.037360594,0.081528656,-0.0540824,-0.06448939,0.036211677,-0.033948336,-0.020929571,-0.07941732,0.009037451,-0.028186796,-0.07120455,0.0052978043,0.029871425,0.024133643,-0.00922318,0.0054672253,-0.029752733,0.026895689,-0.035085198,-0.046411466,0.011655643,-0.053169016,0.07919036,0.0084723625,-0.0002752737,-0.070283554,-0.015885089,0.042236414,0.025412327,-0.062028263,-0.011484679,-0.008255675,0.073726535,0.080538064,-0.01831351,0.007153286,0.015338426,-0.016431611,0.079194985,0.004872894,-0.02152527,0.0036603198,0.025499474,0.017710896,0.02258193,-0.040787525,-0.028839597,0.084676206,-0.06307915,-0.031836547,-0.0070996108,-0.09693092,0.042882793,0.046219844,0.0045346045,-0.027628945,-0.062102217,-0.058200195,-0.0071597127,0.0696403,-0.061322615,0.0018403294,-0.023056937,0.034079805,-0.0033014452,-0.034966886,0.041743107,-0.1365935,0.1135545,-0.08156919,0.023065744,-0.002341358,0.08219856,-0.03004527,-0.08523026,0.01277058,-0.044055298,-0.017520547,0.036275,0.029593939,-0.001509716,0.0059742453,-0.04058601,0.039190575,0.03442485,0.035342243,-0.063974075,0.03799893,0.009260407,0.07566149,-0.056892477,-0.07642264,0.035530236,-0.04176967,-0.051338974,0.07730515,-4.6961973e-33,0.045318317,0.06119016,0.05842884,-0.026671184,0.012379429,-0.045573838,-0.078400046,-0.014812848,-0.07711402,-0.10753487,-0.08342619,-0.013644277,0.019335963,-0.031132665,0.0856221,0.015746173,0.042634815,0.039101336,0.02551937,0.006753579,0.10622225,-0.06878337,-0.04743217,0.05285335,-0.033808146,0.06949504,0.045851525,-0.04755881,0.03368239,0.049188416,0.014741106,-0.028717095,-0.05718963,0.05500229,-0.06811456,0.052188326,-0.06425293,-0.035434257,0.028992537,0.010072699,-0.08376979,0.0063968557,-0.0831305,0.0417631,0.019770876,0.033384036,0.1096493,0.040912293,0.0054131383,0.04745185,-0.0320691,-0.015536821,-0.04105941,0.030531969,-0.0049737063,0.10646495,0.08019807,0.0057268324,0.020438207,0.045080304,0.0038633258,0.0048317504,0.0018798964,0.11818123,-0.062252887,-0.056868326,-0.06942979,0.03121487,-0.012150378,0.007591262,-0.11403935,0.041989677,0.015859079,0.006607477,0.05741601,-0.017066104,0.0071510156,-0.014410341,-0.034112856,0.026150437,-0.09260408,-0.04550033,0.0037257657,0.011634387,0.032545727,-0.056253582,0.025173651,-0.0070249983,0.049980953,-0.03109965,-0.073664755,-0.03607869,0.011686728,0.035647836,-0.084594026,3.641663e-33,-0.010556966,-0.02194536,0.014496729,0.07466648,0.05128772,0.099546336,0.0127763925,-0.0921169,-0.005293356,0.041596577,0.025468362,0.037166853,0.06823506,0.021932432,0.10843402,-0.009987714,-0.08346317,0.066374205,0.012538732,-0.0065150475,0.016493395,0.019045953,-0.018430017,0.04555583,0.018380012,0.088210106,-0.10184116,0.08433503,-0.07150146,0.021779718,0.03709466,-0.016703593,-0.16276854,-0.020252246,-0.027683157,-0.0478467,0.00030881434,0.05604177,-0.070508085,0.03619039,0.07768172,0.022464514,0.011464897,0.13347082,0.000817564,-0.025166744,0.14740452,-0.035579443,0.07342357,-0.07544951,0.04035523,-0.004452163,-0.07226668,0.00091637747,-0.055442717,0.030052764,-0.038504895,0.13256218,0.008572771,-0.025968486,-0.031813417,-0.0831427,0.06753835,-0.02797019,0.014271223,-0.07633369,0.05268393,0.06516914,-0.00029806935,-0.021654116,-0.0026098292,0.09572864,0.0785794,-0.044070214,-0.061417814,-0.009646647,-0.07534077,0.08262802,0.053935427,-0.034156457,-0.05214512,-0.01003537,-0.024082722,-0.00048191982,0.08417026,-0.014548971,0.05889159,-0.0094088875,0.010234952,-0.0006864294,0.001696181,0.039384525,-0.045780417,0.05080298,-0.022749437,-1.6420127e-08,-0.015248074,-0.051869184,-0.06886554,-0.054156534,0.112731315,0.051722016,0.014215512,-0.025495453,-0.014752663,-0.022282196,0.11081345,0.019077834,0.042247012,0.066605866,0.0029454415,-0.07681374,-0.0017012905,0.058234047,-0.10625991,-0.022169802,0.0027118872,-0.012420434,0.018671364,0.10441667,-0.033060312,0.022632334,0.050272673,0.016927458,0.027302861,0.03619268,0.016335199,0.021316633,-0.025173249,0.017281817,0.0008164402,0.10752068,-0.01941244,0.045688797,-0.016760834,-0.006094522,-0.027594144,0.014397665,0.0011091592,-0.018717874,-0.020964688,0.005054593,-0.035621,-0.08123605,-0.065157324,-0.054495126,0.028132757,-0.016319273,-0.018637652,-0.0057615032,0.065747656,0.022008596,-0.005068056,-0.0672446,-0.0091039445,-0.024905914,0.07190794,-0.07309224,0.048534967,0.0321892 +2.3.3.14,"Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36, homoaconitate hydratase. The enzyme also acts with oxaloacetate as substrate, but more slowly [2,3]. ",384,1.0,0.014520024,-0.08343749,-0.07288066,-0.03831393,0.1021234,0.04401219,-0.056209497,-0.010843311,0.042655285,0.011317079,0.036408003,-0.037891295,-0.021205422,0.04846264,-0.017835906,0.028801315,-0.1457609,-0.091494046,-0.017110255,-0.03925573,0.074032634,0.012562047,0.0021405546,0.030584447,0.003380321,0.0026894808,0.07734182,-0.03572342,-0.01845218,-0.05504258,-0.02438875,-0.06998582,0.049930215,-0.068958186,-0.014152091,0.05385914,-0.09718661,-0.12094465,0.022437751,0.049519815,0.024530156,-0.031052206,-0.038061995,-0.029183855,-0.03331287,-0.019252365,0.03166508,-0.014192026,-0.0086052595,0.06545893,-0.03145078,-0.05860465,-0.015464515,-0.01063928,-0.030817192,0.069078155,-0.08083311,0.0057121287,0.013263787,0.011442468,0.035214793,0.04598189,0.03540364,-0.048668694,0.071806476,0.021848993,0.058851365,-0.09308223,0.010321132,-0.0824409,-0.08634376,-0.07975842,0.03285684,0.03837194,-0.0011934864,0.00032198353,0.034576323,0.030203596,0.03554446,-0.087007485,0.006393882,-0.045108177,-0.04649975,0.06132858,0.03246951,0.029510088,-0.025854887,-0.022793863,0.068648994,-0.018136362,0.015875502,0.010927528,-0.024082454,-0.032079637,0.0043762773,0.04043558,0.044661395,0.06495212,0.019726928,-0.0091568865,0.027151838,0.09559527,-0.09057629,0.01960271,-0.042464722,-0.00051366584,0.023184856,0.07556259,-0.056647174,-0.0085560465,-0.00074698037,-0.038820922,0.06323878,0.042324115,-0.0046784384,0.10321365,-0.018960455,-0.017584732,-0.0706952,0.009797912,0.006431902,0.018169671,0.09758758,0.049527727,-0.0368807,0.034925092,-0.10798448,1.2411871e-33,0.10287811,0.042723525,0.007959469,-0.030920662,0.0076033366,0.020895602,-0.044699878,0.031341832,0.009051747,-0.0923077,-0.0735799,-0.027026724,0.030564187,-0.013585107,-0.058974467,-0.057065826,-0.002445357,-0.0010413248,0.0023252477,0.055980973,0.0029811887,0.049791582,-0.015292368,0.00696659,-0.029574664,0.007116536,2.9965238e-06,-0.0034288208,0.043657348,0.03367784,-0.080216534,-0.09958373,-0.06728647,0.023941021,0.00046368752,-0.060410615,-0.04228319,-0.05631531,0.0009498527,0.084989294,0.04417847,0.038683593,0.029840529,-0.009836682,0.050941523,0.0356274,-0.017597537,0.13170345,0.03291978,-0.013586344,0.0043201284,-0.032695323,0.07226619,-0.08756104,-0.061589673,-0.044561587,-0.103895694,-0.04817401,0.026056243,0.046424307,0.036932025,0.11131172,0.013155903,0.0647028,-0.03710587,0.03472949,-0.09071291,-0.07346264,0.03112716,0.025723817,-0.0298726,0.0035020353,0.09228597,0.07324057,0.041205622,-0.07061891,-0.07790566,-0.023287801,-0.013846392,-0.05460193,0.00041232235,0.01970225,0.029182678,0.06344924,0.02268874,-0.061142683,0.03567012,-0.07623184,-0.01409857,0.0419154,0.012788708,-0.050993185,-0.05884198,-0.037827898,0.05399172,-1.790105e-33,0.13200852,-0.09691839,0.00012335258,-0.04680877,-0.04580419,0.029741872,0.061559968,-0.023434188,0.096223906,-0.01769091,0.09287682,0.0357782,0.053565968,-0.1150794,0.06661037,0.004969885,0.014683528,0.015572772,0.0032691683,-0.003939078,0.03402652,-0.02842545,0.014526869,-0.0047121025,0.08280364,-0.000800089,0.018378409,0.07422637,0.028947413,0.012326143,-0.05699874,0.0020962101,-0.042989638,-0.04032558,-0.019649005,0.047595907,-0.03576706,-0.032850176,0.009792263,-0.0154072605,0.020327227,-0.018360537,0.05168122,0.051406518,0.039411772,0.044721182,-0.046168976,0.006468649,-0.049087457,-0.044432204,0.056827486,-0.06299812,-0.0012641626,0.02647394,0.020892907,0.08210412,-0.0029839303,0.026788255,-0.038233604,0.036715467,-0.0047726138,0.016179629,-0.0017580579,0.017573053,0.030402575,-0.048554122,-0.06590764,0.067270085,0.033631306,0.024339085,0.08136304,-0.095612146,0.047166325,0.09404983,0.009818627,0.011215965,-0.06625084,-0.07120211,0.02949295,-0.075601704,-0.053543024,0.050091397,0.037357166,-0.055468746,-0.0020462913,-0.068683304,0.029193368,0.12362854,0.031648956,0.054630317,0.005231114,-0.08102978,-0.08557302,0.054302435,0.12099221,-3.459391e-08,0.0110749565,0.016425602,0.050204918,0.041204177,0.038031686,0.05461313,0.032547228,-0.0018856678,0.047469974,-0.07961955,-0.009474003,0.010013653,0.055941004,-0.0018157884,-0.0038458472,0.048738983,-0.01592617,0.0878393,-0.062786296,-0.01766644,-0.05463253,-0.0411846,-0.08306106,-0.04677208,0.002570184,-0.068292886,-0.018207332,0.021286706,-0.0427276,-0.06923398,0.00847148,-0.010920928,0.045433976,-0.09438724,-0.06854527,0.05586762,0.01869048,-0.028506901,0.019316271,-0.014626324,-0.009664693,-0.056219593,-0.03064137,0.010933132,0.09766139,0.0392944,-0.026788585,0.001569087,-0.0007560688,-0.015832147,-0.0048039886,-0.0017967442,0.027668163,-0.03898119,-0.028484302,-0.016432684,-0.057388917,-0.073873036,0.007762353,-0.09845631,-4.8863778e-05,0.08134831,0.19119905,-0.04890829 +2.3.3.15,The reaction occurs in the reverse direction to that shown above. Requires Mg2+.,384,1.0,-0.0850704,-0.037961375,0.0076757483,0.04803107,0.03322208,-0.06320583,-0.022246907,0.008922036,-0.032806795,0.06416109,0.05274708,-0.016594848,0.023171205,0.008291812,-0.019145804,0.024951508,0.023864022,0.0073758503,0.029288538,0.056949463,0.055265106,-0.035038833,0.027291013,-0.015652817,0.003259752,0.10069303,0.07353384,0.01602816,0.06350731,-0.0092514595,-0.002550147,0.05747294,-0.010230714,-0.06603011,-0.035759453,0.046342824,-0.08434775,0.019163039,-0.011842232,-0.030692946,0.02204927,-0.011934995,0.08014417,-0.080544375,0.03937632,-0.07019952,0.01576349,-0.02152015,0.08748715,0.05576061,-0.007183356,0.006833131,-0.107586436,0.020279687,0.0068826294,0.01937707,-0.09858192,0.014730469,0.0010621253,-0.0112252915,0.01657308,-0.04049255,-0.104515955,-0.013044088,0.070937835,0.0067290785,0.0047262115,-0.052670248,0.027486023,0.0039931913,0.036801472,-0.04307828,-0.033997357,-0.10652316,-0.009804449,-0.0045287944,0.08052476,-0.04166137,0.06083329,0.04309534,-0.008342458,0.0049447757,0.07453315,0.06485785,0.003938574,0.0032859354,0.0003653934,0.0072221044,0.054544125,0.0949379,0.011031168,0.062124606,0.028767515,0.04665447,-0.0074424306,0.017846862,-0.033821985,0.038891863,0.02350306,0.0035965135,-0.03567183,0.037188206,-0.07371112,-0.018688949,-0.055548195,0.01901073,0.0014793231,0.04013669,-0.037781313,0.052880358,0.058753006,-0.009442685,0.058196917,0.059350234,0.007008966,0.07227215,-0.013099761,-0.06027199,-0.062763914,-0.07479253,0.038424008,0.008041973,-0.08996897,-0.017520709,-0.07122503,0.0006094305,-0.003813435,-2.2386388e-33,-0.027345637,0.016371869,0.0845205,-0.050173223,-0.04919932,0.024921598,-0.07908574,-0.042827886,-0.0076070023,-0.0005087961,-0.035877172,-0.050603867,-0.027563015,0.03948525,-0.10966007,-0.09859059,0.035963293,0.0531827,0.036992792,-0.015399749,-0.009950259,0.092103206,-0.06628129,-0.04807236,-0.027351765,0.13513665,0.013090804,-0.10606547,0.025929872,0.006604456,0.079804,-0.05188585,-0.0508858,0.014706569,0.010961015,0.037176125,-0.017544273,-0.02273073,0.024013495,0.02206467,-0.08958613,0.016919596,-0.121682204,0.031214142,0.0497996,-0.09563734,0.039050914,0.021466337,0.0488172,0.073512405,0.057592414,-0.008820651,-0.007761106,0.075387016,-0.03481993,0.0450101,0.01222368,0.06981575,0.043140676,0.027846651,0.03262821,0.04235065,0.053088415,0.021915961,0.04534569,0.0224412,-0.09329915,-0.03265442,-0.013690909,2.868382e-05,-0.00202337,-0.004552584,0.10974845,0.043076843,0.007761666,0.007701133,-0.024110496,0.027489357,0.07299658,0.00030516295,-0.05444144,-0.025005326,0.0015859792,-0.017581226,-0.07338469,-0.001764151,-0.04181639,-0.0514449,-0.010289889,0.05696325,0.059446406,-0.027419245,0.00036703498,0.06585947,0.022869145,1.2232411e-33,0.019470908,-0.017358247,-0.026711073,-0.048166428,-0.089874946,0.041183826,0.0656832,-0.118155695,0.03825241,0.05993953,0.07154609,-0.0015142794,-0.0863361,-0.021413615,-0.0079736,-0.017195094,0.037608407,0.08814077,-0.018384261,-0.051503263,-0.0030990196,0.12164398,0.05871251,0.05352498,0.07922937,0.020667473,0.100108735,-0.008911293,0.051688626,0.084151864,0.014234811,0.061856996,-0.018401708,-0.011040977,-0.05228614,0.058122784,-0.001357525,-0.039208997,-0.015076864,-0.002474919,0.0031918816,0.014160467,0.060025536,0.08646054,0.009958474,-0.013078499,0.039950076,0.004325536,0.043048758,-0.09578555,-0.004572508,-0.010817263,-0.053146668,-0.03479804,0.0431231,0.012473269,0.029289754,-0.022910986,0.060140505,-0.046921365,0.035232786,-0.025304776,0.0834532,-0.16351964,0.02047418,0.07077666,-0.003078255,0.054168303,0.07558067,-0.015589309,0.10683469,0.12683466,0.056450542,-0.049721755,0.028139396,0.015706751,-0.002628665,-0.03986887,0.029626423,-0.12249043,-0.019615028,0.041129168,0.017017115,-0.015489527,-0.051484086,-0.18646753,-0.04527854,0.08062847,-0.023785682,0.00082552154,-0.056037124,-0.038926285,0.02700646,0.026266677,0.06652371,-2.1778048e-08,-0.081197426,-0.060864124,0.06284418,0.0014287616,-0.010233996,0.12428656,0.0078088,-0.030620968,-0.028642155,-0.12010175,-0.008718697,0.024387801,0.032912467,-0.0032362822,0.00740278,-0.0006999446,-0.054760482,-0.035175256,-0.051992256,-0.062943414,-0.064614564,-0.07807665,-0.03773219,0.021267012,-0.03331239,-0.029361745,-0.02666704,0.06672795,-0.027526386,-0.055682518,0.019227562,-0.044927854,-0.06378207,-0.051664624,0.01094831,0.05868389,-0.023146624,0.016692743,0.024616506,-0.111352056,-0.09932669,-0.020547519,0.05604548,0.037048295,-0.07711494,0.04572104,0.024086172,-0.00053421495,-0.071800955,-0.007192083,0.0448061,-0.08596677,-0.0079313805,-0.03730997,-0.019347366,-0.001132971,0.013478961,-0.03178652,-0.019821728,-0.05078958,0.024831586,0.03813761,0.0054175314,0.004037014 +2.4.1.1,"This entry covers several enzymes from different sources that act in vivo on different forms of (1->4)-alpha-D-glucans. Some of these enzymes catalyse the first step in the degradation of large branched glycan polymers - the phosphorolytic cleavage of alpha-1,4-glucosidic bonds from the non-reducing ends of linear poly(1->4)-alpha-D-glucosyl chains within the polymers. The enzyme stops when it reaches the fourth residue away from an alpha-1,6 branching point, leaving a highly branched core known as a limit dextrin. The accepted name of the enzyme should be modified for each specific instance by substituting ""glycogen"" with the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, etc.",384,0.99999994,-0.01118516,-0.06689839,-0.02061062,-0.023948947,-0.008276672,-0.07494281,-0.012400382,0.032986525,0.004173621,-0.014114882,-0.024060775,0.17568186,-0.042834606,0.05535362,-0.12604822,-0.027588883,-0.06606926,0.03429857,-0.024603171,0.066099584,0.110490076,-0.035485897,-0.03532005,0.040841974,0.039920542,-0.04719279,0.02859518,-0.09142491,-0.014239463,-0.07526588,-0.017444953,-0.010788647,0.053857353,0.03723935,0.03968631,0.11091604,-0.049886942,-0.046193678,-0.008620484,-0.009752585,0.069014065,0.014568376,0.026744194,-0.01605858,-0.04075671,-0.079329915,-0.098025784,-0.055107325,0.032128118,0.13251117,0.020555796,-0.072853155,-0.04658381,-0.001551854,0.041598883,-0.0040925182,-0.08497555,0.0022896952,0.047651034,0.101517946,0.012371009,0.07523348,-0.05074156,0.01674056,-0.06304637,-0.025930481,0.12558037,-0.04110556,-0.03388923,0.049849622,-0.054107036,0.04546188,-0.023618476,-0.0622518,0.06330818,-0.0044668545,-0.028515175,-0.034485355,0.0074648494,-0.016421378,0.08261096,0.03218173,0.086269215,0.031116765,-0.08061081,0.06467876,0.026405467,0.0013590498,0.053857256,0.03953529,-0.0053937505,0.007922244,-0.0114379795,-0.0641438,0.035136987,0.035523776,0.023985127,-0.036001198,0.0328691,-0.020439666,0.010566398,-0.015686916,0.03920439,-0.04652297,-0.070477255,0.031915203,-0.03364741,0.029512234,0.07377543,0.036130074,-0.009093513,0.08148519,0.047056686,0.014056564,-0.07196233,0.04710645,0.03190995,-0.043942686,-0.032756507,-0.0175844,0.0018995568,0.002591476,0.048199337,-0.013639533,-0.06764905,0.062287334,-0.034613404,2.4310546e-33,0.04796726,0.04545132,0.047164608,-0.023109235,-0.026866637,-0.032860544,-0.034495916,-0.016893381,-0.06392213,-0.018506264,-0.040857084,-0.006626977,-0.020285703,0.09088822,0.044116665,0.02956242,0.095735885,-0.0023513646,0.03444425,0.018730855,0.0016595083,0.050773554,-0.019431878,-0.013333031,0.06080123,0.044805303,-0.06624019,0.06044355,0.012078374,-0.013738443,0.0017609062,-0.04551841,-0.061874505,0.12105747,0.05546911,0.04081693,-0.04629403,-0.06456625,0.082715556,0.032242216,0.025955144,-0.014402006,-0.000497024,-0.03478251,0.051775746,0.03934854,0.023000803,0.023846364,-0.07014228,0.0877043,0.0058233133,0.07085858,-0.025494687,0.0015831171,-0.09878129,0.06558072,-0.043327134,-0.041387577,-0.01145294,0.060612388,0.050266933,0.064301334,0.013235965,-0.0016450925,-0.0043638255,0.013613187,-0.03893134,0.0047814515,-0.05166504,0.0074806525,-0.04269628,-0.06542325,0.01456019,0.0141268065,0.04989707,-0.02477286,0.018593613,0.05558954,-0.01398538,-0.04254994,-0.03575534,0.039350666,-0.017210083,-0.004506438,-0.057896774,0.05093736,0.060192056,-0.056538828,-0.053193595,0.0711596,-0.038588382,-0.091940396,-0.027882574,0.0318895,-0.06257511,-5.2132363e-33,0.091696694,-0.128814,0.07414084,-0.032146182,-0.07536481,-0.030962298,0.028078403,-0.019161304,-0.0061469227,-0.07937539,0.025536627,0.042615324,0.006492517,-0.086446084,0.0013238181,0.02139369,-0.03986416,0.046614427,-0.082698226,-0.033923175,0.012201728,0.053455275,-0.01653634,0.014492035,0.08301317,-0.048873343,0.039686892,0.06073873,0.038813334,0.049001027,-0.030320551,0.030375088,-0.010559725,-0.0077491035,-0.030989746,0.015245206,-0.0244081,-0.07457451,0.051008336,-0.010455052,0.03648843,0.034520783,0.05611829,-0.01606469,0.073765315,0.059753295,-0.07811668,0.019589495,0.031043826,-0.057313748,-0.020147648,0.036058348,-0.025607716,0.068171255,0.034096476,0.04369747,0.057282757,0.04072454,-0.03770731,-0.0531089,-0.075054094,-0.017315682,0.020430656,-0.0048468644,0.05579961,-9.1469365e-06,0.029393885,0.0017585037,-0.030215964,-0.03135378,0.06886568,0.0051412894,-0.004307251,0.06505507,-0.026345396,-0.016290432,-0.0861253,-0.055043124,-0.029721124,-0.026086606,0.026240317,0.070244335,-0.018399088,-0.020926945,0.06841872,-0.090401575,0.09339177,0.11973826,-0.008613534,-0.008993812,0.032746,-0.03735098,-0.042467277,0.028201966,0.020383492,-4.7612936e-08,0.051255867,0.015320162,-0.050315794,-0.10058916,-0.017129024,0.032405227,-0.0005864342,0.044061366,-0.036259796,-0.057846203,-0.03361359,0.07946093,-0.02866821,0.009305666,-0.03605501,0.0091048,-0.096524246,-0.011883794,-0.03589379,0.011956841,-0.17040187,-0.0044589383,-0.111371644,0.05636642,-0.072841845,-0.061252058,0.06271026,0.06654065,-0.019459527,0.009309708,-0.035377346,0.06966879,-0.06744313,-0.06583399,-0.045604248,0.0071638976,0.014913346,-0.017022481,0.057711348,0.076109774,-0.010453062,-0.06779687,0.025980167,-0.010736305,-0.05873245,-0.025583982,-0.02030918,-0.0070596617,-0.007120091,0.087310046,0.04584655,0.008661467,-0.095171005,-0.086195245,-0.06479571,-0.06083589,-0.021996673,-0.05114226,-0.025820715,-0.06993865,-0.027467063,-0.023142137,0.14520165,0.005254344 +2.4.1.4,"The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends the glucan chain by an alpha(1->4) linkage.",384,1.0,-0.041380882,-0.06788263,-0.05334428,-0.011828481,0.0666564,-0.012526671,-0.0054723537,0.018940896,0.043802667,-0.01851396,0.059997927,0.09687769,0.016140042,0.012278892,-0.1276478,-0.006191287,-0.0746878,0.008800357,-0.09508887,-0.049220685,0.17750302,0.0021414026,-0.016363526,-0.016803624,0.07886138,-0.055684008,0.016136866,-0.044972535,0.017962197,-0.057769716,-0.076117314,-0.054273207,-0.046789832,0.023245318,0.03222663,0.06356161,-0.0330924,0.040690303,0.036328517,0.017615419,0.0145928105,-0.0051794015,0.0024774836,0.06144904,-0.066654295,-0.033862304,-0.11411087,0.087343566,-0.044642415,0.04416165,-0.0008920423,-0.047498,-0.08078517,0.06887527,0.026559155,0.035475515,-0.02550584,-0.030360864,0.032158736,0.046310514,0.0544137,0.009231702,-0.075047,-0.055001535,-0.0030977193,-0.053406965,0.08519781,-0.026040731,-0.045815445,0.019274332,-0.014294416,0.0053328658,-0.01008206,0.052645616,0.0728945,-0.014105703,-0.018136347,0.029003743,-0.021428727,-0.03134607,0.0698619,-0.0074519636,0.08811779,0.07759017,0.01697247,0.0081295185,1.6934093e-05,-0.013856847,-0.008839827,-0.0074668773,0.0348966,-0.08350905,-0.020116143,-0.089311354,-0.0008916645,0.029364768,-0.014188798,0.0019829904,0.109677695,-0.059086822,0.0058711967,-0.037765555,0.048379812,-0.021328917,-0.05674432,0.06235466,-0.033646103,0.0716635,0.06814148,-0.05753273,-0.015043552,0.031508353,0.021949835,0.0030777347,-0.06515422,0.011741369,0.03600741,-0.027269533,-0.05184408,-0.027355306,0.03555224,0.07347922,0.1267635,0.054165073,-0.04201622,0.030959984,-0.07552117,-1.2987051e-34,0.068309285,-0.0040106988,-0.011080798,-0.019345956,-0.06181483,-0.047661405,-0.09374016,-0.028879305,-0.053108037,0.062408272,-0.119074635,-0.03068765,-0.05075594,0.08048179,-0.016166003,0.067502916,0.031236794,-0.0031002918,-0.0015802296,-0.02880211,0.0043841233,0.10763828,0.008680994,-0.00572012,0.03747007,0.043058988,-0.07641603,0.045948103,0.010874947,-0.019310132,0.006341345,-0.019819848,-0.039190218,0.07101361,0.045050133,0.051337652,0.0045803473,-0.022383587,0.061111845,-0.02742075,0.009300717,0.013052212,0.0519999,-0.06119275,0.07704253,-0.0075763175,-0.01121787,0.034642335,-0.029805088,0.087092414,0.020640893,-0.012044065,0.047053367,0.00034800664,-0.061898354,0.03401151,-0.015940696,0.012937218,0.036548108,0.05140733,0.02431551,0.02614253,-0.039745238,-0.03467363,0.03999238,-0.010831958,-0.08752944,0.014824369,-0.032457255,0.112994336,-0.06927017,-0.00444712,-0.033074144,0.082266115,0.048904795,-0.049323253,-0.1007849,0.011726616,-0.002195216,0.024725052,-0.058619093,-0.032620095,-0.064843126,-0.032590777,-0.12403029,0.02371659,-0.050473075,-0.14513035,0.021756532,0.06591424,-0.05224355,0.0026434525,-0.033353325,0.057118572,0.05478882,-2.8217606e-33,0.08185146,-0.039770115,0.09318864,0.035012655,-0.049593143,0.05615752,0.008319667,-0.035631783,-0.011719916,0.020929435,0.019966047,0.06814068,-0.099261455,-0.044706445,0.046584412,0.015227115,-0.074554734,0.08728298,-0.03641913,0.034616616,-0.0033655537,0.10591459,0.010423114,0.008498025,0.06021893,-0.043080874,0.07307567,0.08362588,0.015009466,0.0035299475,0.0037392138,0.004313407,0.019106431,-0.023008894,-0.06370806,0.00872246,-0.0050252806,0.0006625194,0.009721684,0.02192103,0.02093718,0.051711846,0.009495534,0.0055413567,0.06577711,0.006619262,-0.063815676,0.028373124,0.0033741079,-0.083658054,0.040704302,0.0090796035,-0.010829299,-0.019590544,0.060124002,0.056130517,0.034528855,0.034673344,-0.040501278,-0.0059454413,-0.043632176,-0.0036646547,0.01743206,-0.04022752,0.08436777,-0.04114961,-0.012461729,0.0019732064,-0.029579138,0.077652164,-0.00263168,-0.031881534,0.00990072,-0.032062795,0.013994433,-0.10679779,-0.10065182,-0.038775347,-0.053307526,-0.08893106,0.0064481073,0.0035662944,0.03876659,-0.028623706,0.00433864,-0.027657183,0.0472911,0.077615194,0.039811663,0.019052088,-0.06674567,0.0027145974,0.006027971,0.014846414,-0.0027509828,-3.9371894e-08,0.026357422,0.044622153,-0.05338723,-0.054739103,-0.040372778,0.01733016,-0.07284034,0.066689536,-0.0043754987,0.034491263,-0.04150595,0.1308864,-0.047140542,0.014847065,-0.036096733,-0.02184458,-0.034801334,-0.038657174,0.007796886,0.0027554776,-0.092948124,-0.030020842,-0.0850289,0.09345705,-0.013025083,-0.097091876,0.04374843,0.13435651,0.005021829,0.030056933,0.037228025,0.039518632,-0.07286477,-0.06228059,0.023629395,0.030670628,-0.06748149,-0.017892765,0.052099433,0.061925128,0.085317515,-0.003075326,-0.05856612,0.022676695,-0.026658133,-0.06251065,-0.007794516,-0.05625955,-0.012931085,0.092202485,-0.008379631,-0.03151738,-0.07907922,-0.03273199,-0.030707018,-0.060837712,0.02942619,-0.015159398,0.040757235,-0.09841608,0.022156669,-0.004202372,0.117887534,-0.04730748 +2.4.1.5,"The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends the glucan chain by an alpha(1->6) linkage.",384,1.0,-0.04707364,-0.07182386,-0.05358923,-0.010410115,0.06791319,-0.01179412,-0.0064172726,0.019186106,0.043975677,-0.018598227,0.0604329,0.1007228,0.012888608,0.006633984,-0.12602139,-0.0075943563,-0.07785786,0.0060278303,-0.09624903,-0.04561765,0.17695002,0.0065217996,-0.015823139,-0.016932685,0.082782805,-0.05762667,0.018988766,-0.041246876,0.017777888,-0.057215147,-0.0788404,-0.051780626,-0.04790106,0.026329791,0.032523118,0.06559908,-0.034046244,0.04069808,0.035428166,0.015172939,0.011221254,-0.0074509066,0.0022965414,0.05509206,-0.06502017,-0.037669286,-0.11811039,0.0924989,-0.04441503,0.046346594,-0.0011925312,-0.05052968,-0.0804992,0.06868952,0.028514877,0.037083678,-0.02535181,-0.0324313,0.03304223,0.043072462,0.04876444,0.012240106,-0.07435412,-0.05245864,-0.0030061977,-0.05729854,0.08526119,-0.026217522,-0.043652028,0.019799676,-0.017725736,0.003519963,-0.0094940625,0.051514745,0.06928804,-0.013962013,-0.023007877,0.026090091,-0.020870492,-0.033364374,0.06848189,-0.009106382,0.08744182,0.08300428,0.016173484,0.004634604,0.0024216273,-0.006053649,-0.010557243,-0.006819613,0.036249712,-0.08172426,-0.019055398,-0.09359286,-0.0047820425,0.027833069,-0.015782684,0.0063330545,0.10724169,-0.060219478,0.007139749,-0.037708253,0.04907919,-0.020548852,-0.05448953,0.0637077,-0.036371905,0.07398377,0.069683984,-0.058969293,-0.015228775,0.03431576,0.021606818,0.001464223,-0.06323768,0.013067393,0.035995375,-0.026452184,-0.04982956,-0.026808253,0.037463434,0.07367361,0.12493751,0.057298686,-0.047110166,0.030853197,-0.073441364,-1.967262e-34,0.064665265,-0.007854504,-0.011814712,-0.019106358,-0.061861645,-0.046762828,-0.092895426,-0.029280301,-0.053605437,0.06320508,-0.12035129,-0.027343497,-0.05051988,0.07938274,-0.011115592,0.070421875,0.032742236,-0.0017396489,-0.0034705338,-0.030756878,0.008329506,0.10671602,0.009669517,-0.009683027,0.03626872,0.043635815,-0.07683823,0.04887198,0.006833704,-0.021310436,0.008039151,-0.021044368,-0.03446202,0.07581241,0.04472096,0.051448517,0.004402602,-0.021560892,0.06009659,-0.029047739,0.016603913,0.01472499,0.048421767,-0.05559655,0.07638585,-0.007565921,-0.008012246,0.032953594,-0.02783019,0.08738547,0.02142914,-0.012386602,0.04682045,8.919541e-05,-0.05959928,0.036051154,-0.014490192,0.01676176,0.037331782,0.05544945,0.024279436,0.024042292,-0.03531176,-0.033605136,0.037717476,-0.009460636,-0.08921631,0.019169081,-0.033929057,0.11476701,-0.073021,-0.0007673729,-0.033498827,0.08466357,0.04769581,-0.04739369,-0.10089574,0.010665986,-0.0050899377,0.025552394,-0.053334445,-0.03269824,-0.0662259,-0.03328917,-0.12504567,0.026754124,-0.056849677,-0.14649577,0.01779493,0.0669205,-0.0476371,-0.0017590591,-0.035693254,0.05765258,0.055278372,-2.8076795e-33,0.081727706,-0.04232216,0.09673521,0.03339998,-0.047114816,0.055398256,0.0118276635,-0.03787482,-0.012768688,0.017010042,0.014994937,0.070473984,-0.098670565,-0.045665406,0.04455744,0.013856632,-0.07174142,0.09154417,-0.03314993,0.033915054,-0.0072601484,0.103083536,0.006667071,0.006923081,0.057227146,-0.040341817,0.07125338,0.080196925,0.017459886,0.0022572253,0.0049348027,0.0057011656,0.020838106,-0.02427168,-0.060823627,0.010196272,-0.006374293,-0.0021523505,0.009394813,0.021139277,0.020183513,0.05163558,0.007682077,0.0023091736,0.06649464,0.0077418867,-0.06349359,0.024287773,0.0005955482,-0.08179905,0.041696284,0.0069914293,-0.0104458565,-0.0179773,0.059862386,0.05449329,0.035716105,0.034740314,-0.03920717,-0.005803884,-0.040255345,0.0005964833,0.011893467,-0.04299418,0.08061927,-0.038282435,-0.0084063355,0.0057873284,-0.031479176,0.075987615,-0.0020843383,-0.030921852,0.008826444,-0.034907665,0.013321891,-0.10760712,-0.09550411,-0.034388535,-0.04845984,-0.08848525,0.007509143,0.0053140074,0.03562248,-0.023989657,0.0069364165,-0.024055103,0.05044836,0.07376025,0.037722737,0.022594139,-0.06742839,0.0009361843,0.0046867086,0.01160927,-0.0006341535,-3.9338012e-08,0.028395114,0.037376054,-0.05446768,-0.056982886,-0.03424143,0.016874857,-0.07356061,0.066864945,-0.008195311,0.036135703,-0.0404175,0.12860611,-0.043779187,0.014614124,-0.04196979,-0.025646012,-0.03342031,-0.03556025,0.007216482,0.0021292863,-0.09177118,-0.028548619,-0.08166157,0.09353719,-0.011346663,-0.09839389,0.04259325,0.13433577,0.003618728,0.029180702,0.03349809,0.036595374,-0.07811213,-0.059273187,0.027995974,0.03572999,-0.06657751,-0.019872729,0.04969158,0.060111348,0.08682789,-0.004981547,-0.058303114,0.020616105,-0.025478767,-0.061332557,-0.008264176,-0.05591911,-0.0144243175,0.09378801,-0.006922687,-0.03308713,-0.07955051,-0.035193168,-0.030503705,-0.0628503,0.030378036,-0.019470777,0.04040398,-0.095906995,0.025683371,-0.006355235,0.12114401,-0.049953338 +2.4.1.7,"In the forward reaction, arsenate may replace phosphate. In the reverse reaction, various ketoses and L-arabinose may replace D-fructose.",384,1.0,-0.012304246,-0.0275934,0.03019744,-0.049673535,0.05503307,-0.022689637,0.018483989,-0.019801836,0.079382524,0.100185,-0.01439812,0.04352508,-0.02838116,-0.053229492,-0.046094872,-0.07102644,-0.014176103,0.084639415,-0.02719415,0.016586263,0.088038884,-0.022718156,-0.0012449858,-0.048071392,0.026786504,0.11612467,0.045849532,-0.013878838,-0.05633726,-0.1204412,-0.04946154,-0.0038411894,0.012678056,-0.05897013,-0.046869196,0.1177313,-0.041173805,0.0035893552,0.001973497,-0.07989946,0.011862923,-0.03553558,0.02983732,-0.017497962,-0.074120514,0.0071796407,-0.07343293,0.027240263,-0.0051873126,0.009943561,-0.004485501,-0.07944727,-0.105522245,0.008028623,0.07664359,0.010692236,-0.014521112,0.041046355,-0.04810303,0.03493513,0.052188996,0.044248927,-0.047741007,0.008973149,0.065111876,-0.085050724,0.07170598,-0.04361586,-0.032622453,-0.026881399,-0.036143884,-0.0039598863,-0.023606932,-0.041719683,0.016197905,0.0405143,0.011697273,-0.040484924,-0.0036906798,0.033901326,0.04148922,0.036403257,0.07107501,-0.009696496,0.06142345,-0.05084326,-0.040075876,-0.028452836,0.061848372,-0.017955678,0.0014958822,0.010642828,0.043982547,-0.027895782,-0.020639876,0.042869914,-0.040156823,0.04613539,0.06407332,-0.03818563,-0.010332187,0.08885156,-0.09172062,-0.04266353,-0.11384788,-0.0054139043,-0.060415138,0.06446477,-0.03575957,-0.010178334,-0.010585647,-0.019586364,0.08088948,0.03877894,-0.056946963,0.00049229315,0.015471459,-0.102375604,-0.054716144,-0.06565024,-0.044040397,0.044186283,0.108760715,0.07310003,-0.0089212,0.0027702765,-0.091768995,-8.001937e-34,0.04176158,0.07507967,0.03594315,-0.06851547,-0.00037469406,-0.032117225,-0.07151684,0.021741312,0.026178999,-0.05847128,-0.04453153,-0.05122116,0.045906276,-0.0713109,-0.084072724,-0.025302367,-0.0040352982,0.029218778,0.078872934,0.01419233,0.02124819,0.05610175,-0.026047306,0.046028346,-0.0031590597,0.07940406,0.029961253,0.03340177,-0.008103955,-0.005117547,0.059886698,-0.046971306,-0.101302944,-0.01755919,-0.014420491,-0.013558994,-0.08580923,0.016170653,-0.016350951,0.004989221,-0.011543867,-0.024589565,0.055157654,0.040672846,0.012422434,-0.047452286,0.0017802287,0.065371245,0.07805078,0.003478561,0.0042231786,-0.026459979,-0.0030762001,-0.023111453,-0.069417514,0.075529434,-0.034766227,0.010672329,-0.016968824,0.09333161,0.028425962,0.019912928,-0.029598923,0.042046074,0.0019962972,-0.011471035,-0.04125239,-0.024295766,0.02505662,0.08228384,0.012829943,-0.04682515,0.11717144,0.09877394,0.023568252,-0.0014771346,-0.051074456,-0.010028618,0.01164161,0.008068512,0.008632876,-0.02622754,-0.014279376,-0.043275163,-0.024470866,-0.01621279,-0.036941938,-0.10393067,0.0075777182,0.07110006,0.048628453,-0.07764113,-0.10964793,0.024344763,0.008229096,-4.3035675e-34,0.1046648,-0.008334926,0.011093405,0.015225918,-0.05761729,-0.010712402,0.11800447,0.01150706,0.06730365,-0.0078016454,0.052389048,-0.041814353,0.03936578,-0.048461456,-0.03499885,-0.008826456,0.050339762,0.03022344,0.005291413,0.04028089,-0.04374711,0.1001821,0.003494865,0.014423991,0.083795495,0.015913246,0.04878816,0.05784574,0.026183907,0.005149831,0.068874255,-0.03280496,0.007661692,-0.026614763,-0.07502786,0.05593781,-0.05152828,-0.038921375,-0.062128186,0.061403614,0.024037315,0.056025058,0.09780138,0.029964462,0.046789877,0.023992855,-0.0859229,0.0025406533,0.061638944,-0.06359804,0.03200612,0.038264543,-0.010707218,-0.01415304,0.03993424,0.031140748,0.04123755,0.048409037,-0.02343052,0.0009931746,-0.021446368,-0.108378716,0.14490284,-0.114699885,0.056653414,0.05967157,-0.06316371,0.030082237,0.055057637,0.00962885,0.055364575,-0.019997992,-0.014402464,-0.03483905,0.04149743,-0.07228836,-0.07717742,0.0063850777,-0.043134723,-0.024386965,-0.008207599,0.037000705,-0.046614163,-0.049872488,0.03469213,-0.02144927,0.03437229,0.0768543,-0.06574351,0.0129243,-0.07198214,-0.040709704,0.057268634,-0.011454209,0.099780776,-2.6848042e-08,-0.018709155,-0.060635854,0.047157478,0.015566872,0.037879534,0.009262943,-0.05085543,0.03826286,-0.0048981174,-0.09514953,-0.05968828,0.13103764,0.08949313,0.05826229,0.011855927,0.008949622,-0.019808875,-0.059690032,-0.028969092,-0.026669743,-0.10463963,0.015907807,-0.10877226,0.025519898,-0.003171808,0.034379832,0.021079637,-0.042840067,-0.021555452,-0.032402683,-0.004199381,0.00031473243,0.0660432,-0.0022162828,-0.03388939,0.009697792,-0.027926097,-0.021643778,-0.009821996,0.0095986305,-0.0023924992,0.017389081,-0.06066805,0.07418846,-0.059936978,-0.02929544,-0.031905357,0.04023653,-0.07065876,-0.014658582,0.08240364,-0.008408219,-0.06972557,-0.07096907,0.059746042,-0.021534663,0.028742269,-0.019590145,0.045236904,0.08904051,0.07673387,-0.034911305,0.13460481,-0.10220741 +2.4.1.9,Converts sucrose into inulin and D-glucose. Some other sugars can act as D-fructosyl acceptors.,384,1.0,-0.07056759,-0.048117768,-0.0879314,0.057912547,0.06307796,-0.012333733,0.050885666,0.0048760218,0.008127815,0.08111749,-0.0418305,0.05653881,-0.091579445,-0.004268232,-0.007185645,-0.013304901,0.01329922,0.042315893,-0.02951928,0.008289468,0.13567093,-0.042960998,0.024178974,0.014370495,0.03638882,-0.055611752,-0.029679762,-0.048717037,0.0011458609,-0.048848677,-0.045854986,-0.017711503,-0.034958363,-0.01628515,0.034823354,0.07141018,0.022991084,0.011441801,-0.0089102015,-0.09911291,0.050255258,-0.015515917,0.042885993,0.06606115,-0.057848368,-0.06664694,-0.0877612,0.053062264,-0.020305425,-0.041464772,-0.04612035,-0.01651531,-0.05899124,0.041104753,-0.005841303,0.07181688,-0.06267973,-0.013738799,0.0008052137,-0.028119292,-0.037837047,0.025920743,-0.0016228855,0.001139144,-0.0009147601,-0.08534765,-0.04574097,0.012007836,-0.06277332,-0.026451735,-0.031111553,-0.05574738,-0.00061183074,0.066937685,0.12062204,-0.058979563,-0.027524129,-0.0029291573,0.033146594,0.06824519,0.09316436,0.0292268,0.00864095,0.064485304,-0.011272073,-0.022801276,0.02203527,0.053134043,0.01997664,-0.014185668,-0.059668437,-0.0652856,-0.02662537,0.0026506835,-0.09904979,-0.015431391,0.02279171,0.023754075,0.12104607,-0.027119437,-0.0029678189,0.03277794,0.0125430375,-0.06483313,-0.09676698,0.020838164,-0.0013461184,0.062489733,-0.0010204024,0.011909828,0.016017707,-0.044303544,0.087577924,0.0725376,-0.08465304,0.0095700305,-0.014380628,-0.07194296,0.006061794,-0.0720695,-0.040483925,0.07034849,0.09050082,0.057552557,-0.040233597,0.12661472,-0.06417353,-1.3653386e-34,0.00010954486,-0.05817235,0.03310775,0.0074410303,-0.048077874,-0.018015772,-0.055451233,0.00017867143,0.004494056,0.05812481,-0.1235494,-0.0784569,0.044816878,0.10501176,-0.026996125,-0.045154903,0.014770198,-0.054248497,0.04112954,0.01439454,0.0038984644,0.12024586,-0.027314667,0.030870002,0.0361665,0.01148792,-0.093722336,0.10146454,0.08365241,-0.03333056,0.07694673,0.00012123363,-0.005827758,0.021306228,0.061379638,0.06807434,-0.0029455055,0.016730366,-0.01107093,-0.0089595355,0.02149872,0.020859653,-0.022957291,-0.03742629,-0.033168145,0.052122474,-0.008861504,0.04071798,0.06482627,0.049054693,0.05711703,-0.029236834,-0.031826947,0.020486774,-0.050438654,0.048910353,0.039145853,-0.037580833,0.045761865,0.0227345,-0.10859041,-0.041550037,-0.028881082,-0.03651033,0.017048705,-0.01010525,-0.05377922,-0.011913648,-0.05561821,-0.016031139,-0.15151356,-0.055819627,-0.013394809,-0.004339587,0.06432725,-0.039917704,-0.058313258,0.021388443,-0.030570185,-0.029850373,0.037935354,-0.030691162,-0.06330732,-0.026971431,-0.049798172,0.00094158325,-0.059923124,-0.093284026,0.046600092,0.01612293,-0.043288484,-0.037818704,-0.013461399,0.046714034,0.05032395,-3.803804e-33,0.032698005,-0.054196462,0.062862076,0.007061854,0.04525973,0.050348632,0.023571573,-0.113645904,0.1140434,-0.05856803,0.0219722,0.028021865,-0.012737854,0.023446688,-0.0150835505,0.035458278,-0.06796294,0.058089454,-0.04794523,-0.0075230557,-0.08283583,0.13133474,-0.01422739,-0.00013857773,0.04624223,0.030082116,0.054753352,0.07792687,0.060147416,0.014527345,0.02859588,-0.07889855,-0.016509186,-0.04472313,-0.08216731,-0.012110267,0.00024863586,-0.038530737,-0.1130082,0.01890594,-0.03745962,0.06460916,0.053986255,0.045281064,0.050543517,0.029944114,-0.062750384,0.010133392,-0.04299332,-0.0020789371,0.025348905,-0.005042258,-0.0014384298,0.02996487,0.013260897,0.018644145,0.0695809,0.009504717,-0.012825576,-0.038587697,-0.008367029,-0.08812243,0.06444453,-0.046024892,0.03735203,-0.020748,-0.038546577,0.011273154,-0.0037995786,0.026831865,0.02168227,0.00097429747,-0.022458158,0.035500716,0.04691016,-0.08827748,-0.099779695,-0.017480468,-0.005912087,-0.0045010895,-0.061486743,0.041084237,-0.012193758,-0.037318096,0.0043932865,-0.055713464,0.010122797,-0.0061446233,0.03497038,0.02997781,-0.06590334,0.020460878,0.04907861,0.009438817,0.1148189,-2.4345264e-08,-0.014337849,-0.008465734,-0.044734597,0.011818284,-0.055267114,0.0054497328,-0.005362984,0.025834376,0.0380059,0.0042421236,-0.05802191,0.16826183,0.045941684,-0.030037146,0.03326927,-0.009976927,-0.001218659,0.044825666,-0.0045405,0.036039196,-0.07416825,-0.030730726,-0.107793696,0.05004018,0.004868894,-0.08538369,0.016249513,0.02958345,-0.03026229,0.054603383,0.020454613,0.032018527,0.06889163,-0.061797082,-0.018755786,0.024394318,-0.012516254,-0.053730626,0.028574625,0.011791883,0.07056261,0.019501152,-0.04299856,-0.007871204,-0.13224164,-0.02478592,-0.006800672,0.05532023,-0.045812078,0.086620644,0.011756716,-0.026864057,-0.08487967,-0.052230354,-0.032490116,-0.047473498,-0.048527934,0.036699075,-0.0022256593,-0.016692387,0.024960056,0.019763516,0.18573175,-0.04540204 +2.4.1.10,Some other sugars can act as D-fructosyl acceptors.,384,0.99999994,-0.08222236,-0.10240637,-0.046170782,0.01681667,0.037257772,-0.03498154,0.065364584,0.024676796,0.050877642,0.075761646,-0.009119758,0.04666228,-0.09123054,0.031255916,0.01607057,0.0047593922,-0.0020591416,0.04433954,-0.039362233,0.029413642,0.081208095,-0.054531693,0.07533721,-0.0010647059,0.0074817888,0.02662166,0.022843488,0.0032859459,-0.0055116327,-0.08354766,-0.022350054,0.020854834,-0.015607593,0.026580008,-0.029101005,0.022705873,0.023288408,0.018620417,-0.019027513,-0.0777739,0.014902846,-0.0064395634,0.109836034,0.047255814,-0.063984945,-0.08805686,-0.08436966,0.03746672,-0.01087704,-0.03478596,0.0070582014,-0.05873342,0.004182312,0.030082818,-0.0022155112,0.10885273,-0.04461135,-0.029322138,0.009404659,0.028875751,-0.010992937,-0.038001176,-0.017736983,0.008043417,-0.0004771851,-0.0423788,-0.06021683,-0.014117912,0.0014592182,-0.0035365045,-0.010181595,-0.030498015,-0.028620826,0.038044572,0.11761017,0.023126667,0.027489338,-0.024712615,0.031271998,0.038670324,0.02381068,0.04128889,0.084502205,0.05455681,0.010366948,-0.032379985,0.03176978,0.033712886,0.0038268766,-0.00040503778,-0.018336754,-0.048924197,-0.038613126,0.014492709,-0.11319986,-0.03302899,0.0687713,-0.012298513,0.051153716,-0.015034886,-0.0017763571,0.006760749,0.020909848,-0.050896645,-0.10194198,0.009941308,-0.028213011,0.016160576,-0.018881803,-0.051401835,0.002634776,-0.04365088,0.06490723,0.07495939,-0.17064929,-0.028576987,-0.030500202,-0.08805921,0.023482949,-0.09973213,-0.068688445,0.044706497,0.04496871,0.0045222654,-0.0065486273,0.034091715,-0.06799788,-2.3029536e-33,0.021597277,-0.010413995,-0.011236184,-0.034036193,0.01879571,0.0028542571,-0.06064325,0.025424838,0.0013553858,-0.0024873177,-0.11958742,-0.039154254,0.03784229,0.07603629,-0.017813018,0.01679663,0.006216552,-0.02100011,0.03542699,-0.02988907,-0.00038433226,0.07092652,-0.034583014,0.029732311,-0.02130779,0.029635532,-0.09315262,0.10483539,0.13797845,-0.015257925,0.095068775,0.008238299,0.027356204,0.0476084,0.07224701,0.12272563,-0.03654098,0.0075042467,0.0030813913,-0.013020478,0.053097695,0.03925809,-0.045281686,0.012722908,-0.03130162,0.039842166,-0.021117836,0.0026605125,0.0050005335,0.07433193,0.04923581,-0.010948473,-0.013213964,0.05015102,-0.04373184,0.05002793,-0.028902415,-0.05331762,0.045990005,0.010782605,-0.1225285,0.023768842,-0.033250965,-0.037853602,-0.036872912,0.021310624,-0.037857823,0.006189979,-0.050703324,0.011267876,-0.037477378,-0.030089457,-0.026370453,0.0049684434,0.06415313,-0.052088186,-0.0141727645,0.00044449227,0.01435834,-0.002554107,0.039537005,-0.079822116,-0.060076322,-0.018023333,-0.09494484,0.021599054,-0.06750125,-0.092919804,0.057294294,0.03458889,-0.06476274,-0.065011896,-0.017527845,0.026571892,0.04295502,-1.7036897e-33,0.02571935,-0.09395634,0.06982699,0.036300164,0.06707456,0.03902783,0.007307669,-0.10275051,0.1390229,-0.09824556,0.0422178,0.007635599,-0.006195792,0.023197675,-0.007974141,0.021600783,-0.09137219,0.09946083,-0.05673483,0.03936399,-0.08515399,0.0933623,-0.048679702,0.024271183,0.05835329,0.02155055,-0.007748212,0.04799689,0.04270642,0.029214744,0.047949586,-0.057414446,-0.026954394,-0.09094119,-0.015915152,-0.0036273433,-0.05332637,-0.03862406,-0.06125566,0.05763846,-0.054084904,0.04088333,0.039649032,0.05965164,0.06405473,0.055904005,-0.030053899,-0.013941928,-0.05546042,-0.009623802,-0.00717009,0.004074911,-0.022602761,0.039746366,0.060638208,0.07348553,0.055744234,-0.0032248818,-0.021390058,-0.034041665,-0.02964157,-0.10729996,0.058213416,-0.070314094,0.038430188,-0.030085392,-0.037940923,0.052919824,0.05258135,-0.009756071,0.08540054,-0.012550308,-0.01947082,0.05790117,0.021337885,-0.08198256,-0.10383832,-0.021996768,-0.037943725,0.0025554453,-0.07274743,0.04617135,0.0009754267,-0.0053106146,0.020340929,-0.064575024,0.039346322,-0.022289205,-0.03429681,0.044612896,-0.010940399,0.03546997,0.07448627,0.057680506,0.1262075,-2.2277051e-08,0.03146695,-0.030273782,-0.0564858,-0.02252263,-0.020412726,0.014890585,0.009385541,0.024956865,-0.023865256,-0.0041922536,-0.02119343,0.189814,-0.00062930764,-0.0031945463,-0.004004377,-0.018102385,-0.006000767,-0.017359974,-0.03471984,0.052369166,-0.12670338,0.022913152,-0.049261715,0.0070839166,-0.064247705,-0.015665166,0.052882694,-0.026522007,-0.053457245,0.04112131,0.054406088,0.022474656,0.06505081,-0.05201259,-0.016669704,0.026276033,0.0337732,-0.04362233,-0.0022887033,-0.0057107154,0.06725703,-0.025027864,-0.04376504,0.028804298,-0.11976458,-0.055967152,0.001305224,0.057875335,-0.06827456,0.09600453,-0.01217855,0.027663453,-0.08502075,-0.03935357,-0.03848945,-0.024916854,-0.028972793,0.0065475903,-0.051260084,-0.052862253,0.026555195,-0.054523475,0.14805582,-0.016006116 +2.4.1.11,"The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, glycogen phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose [EC 2.4.1.21, starch synthase (glycosyl-transferring)].",384,0.99999994,-0.0932802,-0.037393034,-0.1288501,0.017282687,0.030831894,-0.02382358,-0.035937447,0.012283661,-0.036779903,-0.03821438,0.009502948,-0.0062756236,-0.0938913,-0.0065525505,-0.08825916,-0.047759853,-0.008290193,-0.023000365,0.020590184,-0.031961955,0.06671114,0.031363226,-0.03670577,0.010093606,0.08462902,-0.054447442,0.024745036,-0.067642406,0.003798431,-0.014338054,-0.02396462,-0.055429686,0.044407517,0.010510591,0.009219836,0.061355144,-0.055455834,-0.07561258,0.028992712,-0.032728236,0.03943203,-0.048179522,-0.025642807,-0.069039196,-0.009161688,0.010298643,-0.029332424,-0.028946968,-0.00275262,0.03447374,-0.03243014,-0.05344299,-0.101771615,0.014678602,0.039174214,-0.01316087,-0.047497887,-0.010448458,-0.01517582,0.043697953,-0.00030355746,0.04381631,-0.008897272,-0.011716635,-0.00017737458,-0.06703026,0.11123804,-0.06822465,-0.02193363,-0.060403325,-0.05982243,-0.044434983,0.009606108,0.025606932,-0.00015067293,0.010488535,-0.02663268,0.02699445,0.093331285,-0.012826149,0.08241136,0.0047262795,-0.009752225,0.01362667,-0.055128656,-0.013565263,0.06250947,0.04481454,0.028709272,-0.04649529,-0.033546872,-0.066151105,-0.03226043,-0.01599835,0.0066376613,0.056140523,0.057903156,0.0017166269,0.10655359,-0.078719765,-0.02824386,0.061538976,0.08443712,-0.06079451,-0.030101446,0.04853949,-0.010880004,0.107401736,0.0704822,0.040290494,0.0028748515,0.09247518,0.04115931,-0.00082613144,-0.03435178,0.057133425,-0.049661346,-0.078876376,-0.018177608,0.051301166,0.066536985,0.0053288722,0.07713132,0.079759486,-0.032373782,0.074039,-0.035982884,-1.3716006e-34,0.061074845,0.04585139,0.03388054,-0.00326321,0.0037488362,0.011958663,-0.077828854,0.004282679,-0.0026845047,-0.04684148,-0.032051373,-0.07010412,0.021039383,0.15947618,0.039049428,-0.0071130474,-0.008056196,-0.04085486,0.07268954,-0.0041160826,-0.009807998,0.084905066,-0.025576754,-0.0023998283,0.028086139,0.062199466,-0.05222334,0.039535936,0.03847507,0.00053573,0.022188772,-0.08680806,-0.0076438393,0.061998814,0.033788707,0.0155093465,-0.029063342,-0.09838799,0.10335449,0.041981846,0.04843424,-0.027104223,0.0027668898,-0.031214196,0.060102977,0.034726277,-0.052794788,0.01864456,-0.009442516,0.04491938,0.002113057,-0.027297497,0.056755397,-0.0459103,-0.04960578,0.08209976,-0.010583829,-0.020788819,0.006899782,0.085999176,-0.02583943,0.14192727,-0.00026112358,0.055804845,-0.021446098,0.009565204,-0.06358751,-0.029927215,-0.080702856,0.063333474,0.00840708,-0.040388502,0.054133616,0.027358055,0.01460234,-0.06283706,0.041095752,0.05419784,-0.053386014,0.003150041,-0.055091947,0.09330585,-0.037057783,-0.016160198,-0.08198136,-0.006405687,-0.049594916,-0.028323716,-0.03234401,0.021878222,-0.004133101,-0.0064357924,-0.062055703,0.025828943,-0.04192096,-3.0762715e-33,0.14109893,-0.11134283,0.06843767,-0.06185557,-0.03471196,0.011095787,0.027379842,-0.09526258,0.023051342,0.017721642,0.0038298024,0.0060593872,0.041473158,-0.09183482,0.0007177328,-0.023177661,-0.059544582,0.036942333,-0.06468218,0.0035464582,0.04796336,0.045420527,-0.0024811109,-0.01344774,0.079368815,-0.075046964,-0.005490096,0.09326558,0.0030113943,0.015437244,-0.04157362,-0.03230441,-0.057775106,-0.03517366,-0.052916095,0.030193934,-0.012841197,-0.005093023,-0.023474136,-0.051616866,0.017232845,0.08086633,0.012055713,0.035566013,0.07638936,0.058824006,-0.037178904,-0.039178666,-0.022110637,-0.040538777,0.012945779,0.024139116,-0.013357525,-0.019973865,0.011765102,0.061551314,0.026614353,0.00015946325,-0.020171562,-0.050341144,-0.035805687,-0.04755528,0.07978368,0.018355254,0.030574713,0.038547017,-0.008475379,-0.005758176,0.066235036,0.04357241,0.10730659,-0.033056047,-0.03114082,0.06430717,-0.011951765,-0.003129506,-0.079271294,0.021978011,-0.0194179,-0.08358263,0.084474005,-0.0061565833,0.022591878,-0.018756287,-0.027450722,-0.050803926,0.03458543,0.17890216,0.002401358,0.035586398,-0.035759363,-0.004460036,-0.06973687,0.022587499,0.029194467,-4.3383352e-08,0.031329595,-0.04745902,0.044992454,-0.08463461,-0.005076665,0.049512174,0.028936064,-0.028918337,0.04543871,-0.002015602,-0.060351305,0.0560354,-0.015842607,-0.031328138,-0.05044954,0.024382414,-0.075837396,0.043171816,-0.012741034,0.055902675,-0.09785538,0.019816684,-0.11013963,0.085061386,-0.04586071,-0.08439621,0.06624015,0.08257461,-0.04939308,-0.034632996,-0.046673443,0.09229537,-0.01640682,-0.052090343,-0.057699375,-0.04067162,0.06676109,-0.020623758,0.0020241435,0.025460623,-0.009168117,0.0012003344,0.008235963,-0.02879925,-0.0123373,0.03925234,0.023394711,-0.053119555,0.04034497,0.0292378,0.04214622,0.0057218093,-0.06610271,-0.1125915,-0.07377215,0.0029455011,-0.09867992,-0.051387455,0.011632786,-0.020693861,0.02190298,0.036277402,0.19242011,0.017583536 +2.4.1.12,Involved in the synthesis of cellulose. A similar enzyme utilizes GDP-glucose [EC 2.4.1.29 cellulose synthase (GDP-forming)].,384,1.0,-0.030069776,0.02106364,-0.09292604,0.059928186,0.015054127,0.035248213,-0.019488165,0.0402319,0.07962006,0.018853916,0.021502832,-0.021951191,-0.053684603,-0.020052593,-0.058876585,-0.06369014,0.004309791,0.032682877,-0.03667662,-0.033428296,0.10408399,0.010543211,0.036738846,-0.02776886,0.0820446,-0.046889145,0.027828334,-0.067176685,-0.045440253,0.009533208,0.0029883988,0.004611495,0.07148323,0.044338018,0.040149905,0.094722494,0.026378237,-0.051716182,0.014584064,-0.039142635,0.055431932,-0.07781141,0.010590264,-0.05105799,-0.025358483,0.02235906,0.0252131,0.014625577,-0.05021072,-0.028870773,-0.069389045,-0.012697907,-0.0077756336,-0.0240067,0.04209915,0.031921163,0.012463734,0.02658275,0.06354381,0.028216826,-0.069168285,0.036487073,-0.042276207,-0.036967635,0.043910667,-0.08232156,0.05967631,-0.038083535,-0.100292005,-0.071175314,-0.017648308,-0.04667564,-0.048957743,0.029479824,-0.030378625,-0.00982621,-0.01668058,-0.044283405,0.067889675,-0.020108562,0.09592929,0.05041749,0.05792806,0.020602658,-0.04090433,0.013818657,0.07859744,0.05046032,0.036196027,-0.07793916,0.037264463,-0.054859933,-0.07113928,0.058915507,-0.041686554,0.07279714,0.045651667,0.046578687,0.121098764,-0.07776745,0.0429383,0.04619502,0.061318066,-0.07920252,-0.0025902393,0.02743817,0.022091368,0.1016242,0.04965606,0.039358277,0.006043232,-0.014575308,-0.032914452,-0.011080484,-0.02068903,0.056202047,0.032034524,-0.075415164,-0.042171605,0.052866653,0.042812295,-0.005990013,0.043375503,0.08102067,-0.058535516,0.073901474,-0.03854204,-4.069179e-33,-0.010961375,0.009434932,-0.04010521,-0.007637882,-0.027358303,-0.027372865,-0.04280634,0.023446102,0.032068532,0.031105567,-0.082684465,-0.033036143,0.019810207,0.09720641,-0.022371305,-0.029899843,-0.015085053,-0.074273586,0.09949976,0.058174226,-0.036247026,0.03515921,0.02718359,0.053242616,0.033903945,0.0048053022,-0.01177435,-0.04595558,0.11156517,-0.031938404,0.10366482,-0.035566606,-0.06386117,-0.01798171,-0.010208911,0.017132927,-0.027965987,0.011440577,-0.0452341,0.037552822,0.04224203,0.038058925,0.02521257,-0.046649892,0.014449908,0.047152825,-0.02952739,0.04277613,0.1089229,0.060284093,0.07070586,0.07712463,0.015689129,-0.05252528,-0.002008819,0.06427798,-0.010279803,-0.04277774,0.04209936,0.00780822,-0.04166671,0.052927103,-0.084808655,0.009509822,-0.026516268,0.031458996,-0.026834283,-0.009957989,-0.041045435,-0.0013590733,-0.09460653,-0.10235969,0.06968149,0.017884662,0.024100255,-0.02002331,-0.06972229,-0.040286098,0.016803496,-0.050517153,-0.012476734,0.053012203,-0.02739121,-0.04231535,-0.04440478,-0.05085405,-0.08901062,0.0439148,-0.036610838,0.0063354787,0.028820455,-0.022801014,-0.08693768,0.041558277,0.009890218,6.0431177e-34,0.08924861,-0.042204656,-0.005393837,-0.05459416,0.018191587,-0.059632733,0.013662532,-0.118881375,0.021695552,-0.014711815,0.08053614,-0.018941974,0.032610063,-0.0055207876,0.017273605,0.02241902,-0.14251246,0.09334397,-0.040640518,0.001984613,-0.026028141,0.069059014,0.07929413,0.035524905,0.010168045,0.0052612084,-0.003684252,0.08657436,0.08154353,-0.02044271,-0.014089422,-0.07817251,0.012217026,-0.028252078,-0.07896832,0.048740037,-0.031579453,-0.03243228,0.061154388,-0.028945452,0.021654531,0.060437877,0.027545694,0.005858201,0.0251235,0.058236163,-0.02638413,0.033352774,-0.0025634065,-0.072741024,0.01435534,0.08128019,-0.09603579,-0.054091115,-0.0031735243,0.009894044,0.030493055,-0.014983018,-0.06305995,-0.09965024,-0.060149398,-0.027202217,0.14490631,-0.031968318,0.058485202,0.09920091,-0.055270035,0.014938764,0.06506295,0.045947272,0.05390741,-0.0054243533,-0.014391523,-0.025295163,-0.004504802,-0.06329338,-0.0697015,-0.028328573,-0.023828156,-0.043689802,0.06255609,0.06574153,0.02218875,-0.09309111,0.0050735893,-0.055029858,0.022157956,0.038128674,-0.028542157,0.037115544,-0.045835316,-0.044223793,-0.005704443,0.060027327,0.027821826,-2.8816405e-08,-0.05375545,0.001783169,0.07067637,-0.057989325,0.013154026,-0.03309867,0.01896322,0.05149941,0.045047425,-0.036111847,-0.03702152,0.12755288,-0.05246449,0.055677906,0.009780806,-0.017592046,-0.08618239,0.013400379,-0.0152012715,0.0074805003,-0.031794418,-0.0061231987,-0.1255967,0.078427754,0.0009857299,-0.08541432,-0.007513705,-0.0065849945,-0.011296264,0.0037928466,0.01955589,0.09324211,0.022990866,-0.030572051,-0.0971909,-0.02974414,-0.02484577,-0.068693005,-0.033756163,-0.029755738,0.051042743,-0.0923857,-0.023942718,-0.016315227,0.007960298,-0.012428401,0.0056900326,-0.03962781,0.016738895,0.013799869,0.003172873,-0.010625173,-0.04806669,-0.077218115,0.014057074,-0.023419319,-0.07956895,0.005209371,0.0667913,-0.013355891,-0.028297188,-0.009403545,0.20496003,-0.04696657 +2.4.1.13,"Although UDP is generally considered to be the preferred nucleoside diphosphate for sucrose synthase, numerous studies have shown that ADP serves as an effective acceptor molecule to produce ADP-glucose [3-9]. Sucrose synthase has a dual role in producing both UDP-glucose (necessary for cell wall and glycoprotein biosynthesis) and ADP-glucose (necessary for starch biosynthesis) [10].",384,1.0,-0.11792636,-0.025246026,-0.086076915,-0.003916045,0.04251868,-0.007323086,-0.0007422262,0.0349114,-0.047111243,0.006924845,-0.015354322,0.03861877,-0.1363236,-0.013217859,-0.035742443,0.00189011,0.016140776,0.005197104,0.10400379,-0.036602635,0.06480326,-0.01298449,0.0020539914,-0.040307842,0.11873598,-0.076933,0.05663063,-0.027588049,-0.04134331,-0.038155016,-0.07003784,-0.07761996,0.017746823,-0.07688042,0.038540177,0.1335215,-0.045823563,-0.04447401,0.006191627,-0.07815838,0.10828535,-0.038934916,-0.030918313,0.018462393,-0.037475087,-0.0718113,-0.06876163,0.04010631,-0.0075389333,-0.034992233,-0.045785394,0.014960623,0.0034326178,-0.013456815,-0.00737229,0.031152453,-0.06969213,0.011901008,-0.022654649,-0.04114205,-0.05494517,0.040717788,-0.011767762,-0.063969724,0.09343785,-0.02667669,0.076473765,-0.052394703,-0.062057883,0.08425271,-0.042502552,0.00973235,-0.044959858,0.049665365,-0.014008745,0.030524932,-0.048755776,-0.004828115,0.064753346,0.022308528,0.09677156,0.010542081,0.005158591,0.04914397,0.019384185,-0.039066494,0.04478218,0.050831683,-0.021543778,-0.015647732,-0.016014049,0.031941358,-0.050849903,-0.009304929,-0.06376885,0.03637698,0.00035893623,0.0273777,0.020214628,-0.094294906,-0.019565554,0.084621295,0.0047101458,-0.08824149,0.012770515,0.011396549,-0.018873949,0.0036339154,0.02495534,0.09749959,-0.009538817,0.044643495,0.02619279,-0.010255905,-0.022615358,0.06424888,-0.10088083,-0.099189855,-0.020287668,-0.0045501795,-0.032778315,0.011955878,0.026566993,0.06243214,0.04706761,0.07225251,-0.028682306,1.7963172e-33,0.074845836,0.0011753277,-0.034073688,-0.025425864,-0.00019186939,0.031110935,-0.060705364,0.0019845613,-0.061005037,0.059264388,-0.07350318,-0.14297654,0.08457979,0.10710407,-0.03617613,-0.048297286,0.041909028,0.014124318,0.07740206,-0.009025336,-0.06081532,0.07951318,-0.034806635,0.006797316,-0.0021313436,0.027635435,-0.12266903,0.08550993,0.06483965,-0.018656349,0.067855746,-0.04953275,-0.061782613,0.0087672,0.059597455,-0.044571873,-0.0842643,-0.08115346,0.03498344,0.025616053,0.03333784,0.05303355,0.05539179,-0.030511793,0.059411254,0.09457237,-0.043148074,-0.032794792,0.03217694,0.036449995,0.044719376,-0.0075970017,0.027816284,-0.011226315,0.027949998,-0.0052034943,0.0028562134,-0.018754171,-0.009378238,0.044226285,-0.06525618,0.030279186,-0.02150328,-0.014410352,-0.066629454,0.050159357,-0.054398857,-0.074073985,0.011181792,-0.0050088665,-0.02341302,-0.07704787,0.04993156,0.034657333,-0.013272146,0.023966702,0.013631433,0.054585278,0.025488384,-0.014348939,-0.010296537,-0.029377079,-0.063523464,0.00031956309,-0.0008867633,-0.030524636,-0.06733532,-0.031261817,0.057482284,0.030985178,0.018736262,-0.0050126095,-0.08917448,0.020701122,-0.021464009,-4.6180938e-33,0.07791323,-0.054677866,0.024225166,-0.05378708,-0.07351529,0.01730774,0.06478145,-0.15795074,0.09595281,-0.022385148,0.043341324,-0.008863146,0.03431372,-0.02140942,0.012871109,0.06557746,-0.07694674,0.05005717,-0.020431494,-0.0047137067,-0.001581353,0.167034,0.047100507,0.094287746,0.09100032,-0.05071391,0.012323073,0.07704543,0.061305504,-0.019234445,0.034665287,0.000659342,-0.051029127,-0.040344648,-0.031895444,-0.017065102,0.024976965,0.016159948,-0.0127790235,0.0421555,0.010372943,0.067312345,-0.030694136,0.027193794,0.08206437,0.017449882,0.012115548,0.0021550145,-0.07850525,-0.03791914,0.0020765692,0.0008242773,0.00884641,-0.03753904,-0.006421659,0.07711247,0.048606545,-0.016376598,0.01962563,-0.028049018,0.010467911,-0.022060504,0.08515477,-0.034682557,-0.0010818106,0.11352014,0.041442405,-0.0062342654,0.0033548686,0.006796091,-0.033350866,-0.01971185,0.010159572,0.07729845,-0.023084333,0.03214149,-0.06616126,0.0026120907,0.019407758,-0.04928934,-0.060711194,0.049731713,-0.050550546,-0.026892388,-0.047337323,-0.015043282,0.034565415,0.0035900008,-0.0027420446,0.036234614,-0.038442276,-0.0035133036,-0.027013393,0.019308975,0.059546664,-3.86413e-08,0.057146713,0.0073338617,0.057542164,-0.055637494,-0.04603368,-0.027789582,0.015957808,-0.024266992,0.048215806,0.0018565637,-0.06642165,0.119109005,-0.040431798,-0.027059088,0.05399271,-0.04739578,-0.018355524,0.021897981,-0.06356332,-0.016660636,-0.05261195,0.005604045,-0.13362947,0.07001924,-0.008802021,-0.05536338,0.07835485,-0.019705232,0.04981177,-0.026735475,0.013072418,0.05446104,0.07054212,-0.011310473,0.010334256,0.015519978,-0.025810791,-0.0740855,0.006722607,0.09449843,-0.013291231,-0.051306903,-0.014424182,-0.009317025,-0.061862472,0.046980273,0.03234614,-0.017271638,-0.01898341,0.0066440166,-0.008495844,-0.048500724,-0.066924624,-0.08231672,0.05537542,-0.027763756,-0.123545706,0.010438472,-0.0016261042,0.030268956,-0.02660428,0.028633628,0.13763122,-0.096395895 +2.4.1.14,"Requires Mg2+ or Mn2+ for maximal activity [2]. The enzyme from Synechocystis sp. strain PCC 6803 is not specific for UDP-glucose as it can use ADP-glucose and, to a lesser extent, GDP-glucose as substrates [2]. The enzyme from rice leaves is activated by glucose 6-phosphate but that from cyanobacterial species is not [2]. While the reaction catalysed by this enzyme is reversible, the enzyme usually works in concert with EC 3.1.3.24, sucrose-phosphate phosphatase, to form sucrose, making the above reaction essentially irreversible [3]. The F in sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.",384,1.0,-0.14647663,-0.04765253,-0.11234586,0.036667287,0.10275224,0.035607584,-0.022782065,0.044870764,-0.027098542,0.031096954,0.021859666,0.054841146,-0.117326714,-0.025292167,-0.07325219,0.015827816,-0.02812794,0.0214832,0.019443415,0.03696786,0.13760738,-0.050804995,-0.030617446,-0.030990105,0.093625166,-0.009670182,0.048057765,0.041993547,-0.040916074,0.03130324,-0.06819568,-0.016010242,0.016302936,-0.03475616,0.0697643,0.18057069,-0.06072099,-0.13342303,0.016480373,-0.077910386,0.05078371,-0.02556037,0.009662627,0.0022883224,0.016310291,-0.0039301137,-0.04103506,0.0020775376,0.018732268,-0.10663103,-0.028674204,-0.0008600413,-0.0105324155,0.014283649,-0.027392853,-0.0043292046,-0.12573561,-0.0040695462,0.03039247,0.015462407,-0.037705198,0.026898783,-0.00049383566,0.006635915,0.08732609,-0.035154037,-0.055460796,-0.06275693,0.016550587,0.06787052,-0.0593809,0.0011703005,0.041795943,0.029894497,-0.007092793,0.039295107,0.016381865,-0.0006245355,0.0047306134,-0.032829218,0.03939657,-0.026165731,0.045631822,0.03817282,-0.012913025,-0.018817263,0.035550456,0.050987434,-0.0013758937,0.026258823,0.063518204,0.057842843,0.015915537,-0.05981291,-0.047029696,0.067852356,-0.047958776,0.03144303,0.01841797,-0.016345827,-0.033353854,0.11090981,0.0059014536,-0.08150107,0.017338151,0.029641483,-0.04637989,0.08497704,0.012120026,0.08640241,-0.019573107,0.054531824,-0.017069958,0.008642081,-0.023738546,0.03236658,-0.010341309,-0.0792604,-0.07949795,0.023144297,-0.0018578053,-0.05279213,0.0022646994,0.02110463,-0.02914517,0.072074704,-0.07120525,2.7561247e-33,0.037961923,-0.04994488,0.0063303695,-0.12921067,-0.00864236,-0.04432669,-0.026441801,-0.06006394,-0.039834686,0.044276644,-0.09650475,-0.085297644,0.017672135,0.026011573,-0.049149584,-0.02652616,-0.0067139203,0.024088105,0.089015365,0.011605246,0.050472114,0.041308343,0.027167058,-0.0240663,-0.00547065,0.011927848,-0.0755683,-0.0078899935,0.0810136,-0.018127406,0.10837091,-0.025007835,-0.10040395,0.0017112962,0.034288064,-0.05972212,-0.08981965,-0.071614884,0.016213994,0.07305334,0.00700274,0.060874928,0.036932647,-0.004839992,0.022539455,0.056583647,-0.0032608598,0.09034309,0.071925305,0.019346168,0.036903467,-0.029730774,0.019721426,0.054949615,0.04783209,-0.027133925,0.009993206,-0.014927243,0.035153683,0.029107446,0.0031778086,-0.00015800507,0.016192123,0.017411275,0.034151368,0.008767309,-0.12835583,-0.014649193,-0.022292798,0.01182629,-0.062611304,-0.09097436,0.010699822,0.042531148,-0.0026849874,-0.017169472,-0.011801454,-0.0026374066,-0.051214147,0.025008745,0.00046084845,-0.050971143,-0.023054522,-0.010079298,-0.07296024,0.04511093,-0.11375295,-0.079162836,-9.792764e-05,-0.0029194076,0.027739223,-0.016484268,-0.09470028,0.0019040135,-0.03776846,-4.656276e-33,0.09106723,-0.03786268,0.053480856,-0.03391683,-0.05817817,0.03364629,0.047264077,-0.08687272,0.045975998,-0.014499356,0.065473095,-0.012181698,0.05116465,-0.042069625,-0.04003269,0.038869016,-0.056059424,0.110644475,-0.0065853475,-0.0147488285,-0.047734313,0.15815376,0.010484866,0.040146813,0.08405733,-0.04409731,0.021028688,0.07643072,0.033905897,-0.029061992,0.0051357937,-0.003888842,-0.038315974,0.011054264,0.0013210604,-0.041751206,-0.048276857,-0.06135531,0.054756127,0.073378034,0.09271924,0.05014738,-0.008168447,0.016143776,0.04218538,-0.050069205,-0.03645215,0.0722449,-0.0036245603,-0.03166736,-0.000427846,-0.013414872,-0.036502466,0.0017468676,0.050787214,0.044615157,0.051355865,-0.012803847,-0.03495722,-0.046903264,0.05184777,-0.06767346,0.069452435,-0.013913345,0.0826742,0.11847538,0.075876154,0.06582544,0.0013595853,0.0064446684,-0.00787808,-0.029733786,0.018683199,-0.0011864337,0.0076924977,-0.010561658,-0.09936109,0.011774637,0.0225977,-0.048246976,0.01657501,0.014009625,-0.005294684,-0.04199427,0.027794536,-0.019093694,0.041557252,0.059224464,0.009327834,-0.027336368,-0.031268947,-0.07862714,0.021905163,0.074773476,0.050959274,-4.7653725e-08,0.019471185,-0.062031418,0.014405641,-0.034436338,-0.0039855847,-0.0018523415,0.013544907,-0.03856259,0.013181889,-0.036687363,-0.022899149,0.059347782,-0.029278856,-0.049882486,0.027318982,-0.068565264,-0.003703721,0.09663284,-0.028636629,-0.008514321,-0.06263449,-0.10401711,-0.13255277,0.09233031,0.043931667,-0.008149037,0.02060065,0.066272,0.0032678696,-0.015903773,0.010721619,-0.00025768188,0.013728878,-0.003230942,-0.01684074,0.0895081,-0.090517305,-0.05964574,-0.027770013,0.047604706,-0.0125048235,-0.02582718,0.0062159477,0.009858806,-0.076709025,0.031678226,0.027783828,0.034979828,-0.05091924,0.051948387,0.037276767,-0.050757,-0.073055364,-0.07281077,0.04219389,-0.030106304,-0.014646514,-0.009392126,-0.04450962,0.022460623,0.04191642,0.03789153,0.11330241,-0.07633663 +2.4.1.15,"See also EC 2.4.1.36 [alpha,alpha-trehalose-phosphate synthase (GDP-forming)].",384,1.0,-0.033637203,-0.032067284,-0.09919081,-0.020127622,0.027490733,-0.009879577,0.017698202,0.031290326,0.0049178405,0.005602937,0.07361606,-0.04918553,-0.04806543,-0.011708522,-0.06164781,-0.063578896,-0.07199554,-0.032195468,0.034670882,-0.055659745,0.08442497,0.044052172,-0.008613282,-0.014385916,0.025724838,0.007901675,0.033190355,-0.057146095,0.029107092,-0.04690545,-0.01742032,0.00086821034,0.11511863,-0.006749681,0.048310827,0.060072124,-0.042482235,-0.043559942,-0.03598581,0.06586813,0.09107437,-0.08003309,0.012920573,-0.021737233,0.0008476681,0.0112481695,0.015277363,0.015636655,-0.05037066,0.004255611,-0.02957952,-0.051214553,-0.055473052,0.03449331,-0.0014778068,0.023556031,-0.068748295,0.024457468,-0.06053448,0.055520073,0.04241094,0.011541825,0.0049448223,-0.02647453,0.056418903,0.020318288,0.10135679,-0.03515889,-0.034052856,-0.041771233,-0.055926748,-0.045863535,-0.013523338,0.02377392,-0.06278711,0.055495556,-0.0084658535,-0.083891585,0.06947266,-0.044106107,0.059559245,0.035509147,-0.021584827,0.0043013827,0.022061925,0.01908291,-0.017011886,-0.005463058,0.010161494,0.044681914,0.037428677,-0.022971874,0.06797941,0.04354119,-0.03215901,0.10299511,-0.019711383,0.07090519,0.0669116,-0.055094413,-0.031526636,0.07283625,-0.038245287,0.001489381,-0.07847681,-0.03328762,0.016414879,0.06421705,0.011749851,0.098101646,-0.0058371513,-0.008372222,0.049488906,-0.012391318,0.023057548,0.045561127,-0.012287267,-0.057823196,0.08157985,0.02700605,0.07150552,0.006166673,0.016606381,0.072763644,-0.024195008,0.04256114,-0.06969675,-2.9284341e-33,0.055683654,0.118118234,0.04541436,-0.014877703,-0.059370093,0.040967975,-0.13776976,-0.024980782,-0.078255676,-0.009005658,-0.06965596,-0.011089641,0.03319063,0.02883734,-0.013003037,-0.0851758,-0.011963885,0.09210059,0.073370926,-0.0009407481,0.00024416592,0.041335154,-0.02487174,-0.008914255,0.03401208,0.030073024,-0.08003545,-0.028247831,0.1056386,0.008064123,0.05553018,-0.027705252,-0.09992653,-0.031244468,-0.025728641,-0.06425738,-0.040829547,-0.00018889633,-0.05109225,0.02789176,0.020135658,0.04926176,0.045730855,-0.046522938,0.03670317,-0.10985608,-0.047062054,0.05978508,0.099204265,0.016719207,-0.063530855,-0.07054906,0.051441055,-0.04200722,-0.004980229,-0.006619987,-0.06081408,-0.024733473,-0.0035630704,0.04120256,-0.005574825,0.13393909,-0.06003032,-0.015528329,-0.065695666,0.008053165,-0.017886773,-0.05568326,-0.045246135,0.043724433,-0.0010742368,-0.03697623,0.103222415,-0.009731929,0.059293546,-0.062294148,-0.028476065,0.04135395,-0.07118291,-0.001342049,-0.08894379,-0.024351124,-0.0016707003,0.034215715,-0.017831007,-0.011667072,-0.01840403,0.030636225,0.014607622,0.04922017,-0.0020767357,-0.044249363,-0.121621385,0.039168287,-0.07694445,2.0693404e-33,0.053586826,-0.06561823,-0.031097267,-0.066099524,-0.03341586,-0.0042111967,0.05153113,0.00972644,0.07374349,-0.036583416,0.11974075,-0.032552388,0.041741617,-0.11041773,0.0562338,-0.05442204,-0.022089444,0.037405193,-0.00093983463,-0.022643935,-0.010145319,0.05370176,0.0058851624,0.09578662,0.053319864,0.0095087085,0.027041636,0.08446495,0.023089133,0.009580374,-0.034221422,-0.032491054,-0.05047615,0.029757554,-0.11833335,-0.024051612,-0.011533048,-0.055552717,0.004039878,-0.03876079,0.022554565,0.08482641,0.037052307,0.06007488,0.074871264,0.09409347,0.08942438,0.069185704,0.008811083,-0.04097905,0.06378741,-0.0028838895,-0.07534247,0.0019801066,-0.016526029,0.032531478,-0.009935178,0.047797255,-0.02266015,-0.06807933,0.021170584,-0.05806881,0.058019686,-0.036265876,0.017113686,-0.0022632503,-0.026308283,0.07022954,0.07855407,0.021614572,0.035429448,-0.027154904,-0.03321043,-0.007223515,-0.013090768,-0.031731028,-0.09755679,-0.033097625,0.07353413,-0.05129437,-0.03674644,0.04244984,0.011060299,-0.026049608,0.06096467,-0.044221804,0.015349832,0.081985116,-0.016001042,0.08193228,-0.16651046,-0.045581076,-0.10559772,0.102900386,0.025728174,-2.8943566e-08,0.08648788,-0.013354538,0.045883972,-0.016184941,0.055105664,-0.008854459,0.048748773,0.042437304,0.10607417,-0.018557843,-0.040133137,0.044753388,0.027826084,0.013162432,0.04763593,-0.014731013,-0.024157772,0.060406335,-0.0451594,-0.05744775,0.016568325,-0.0019684422,-0.10125275,-0.009630765,0.02846016,-0.03624401,0.025661577,0.036516502,-0.027339224,-0.03920161,0.025261523,-0.0017731377,0.07220148,-0.025275195,-0.01777151,0.05063133,-0.00061212695,-0.020430923,-0.05160613,-0.002347656,-0.046411626,-0.0970596,-0.0434568,0.03664501,0.013777151,0.026005361,0.01024289,0.042151,0.02380378,-0.08382296,0.020358277,-0.037276786,-0.03198998,-0.06356567,-0.040406015,-0.0063393023,-0.006731498,-0.07797468,0.053950284,-0.049640533,0.061715413,-0.019618886,0.15344758,-0.014802589 +2.4.1.16,Converts UDP-N-acetyl-alpha-D-glucosamine into chitin and UDP.,384,1.0,-0.07993207,-0.1134895,-0.020164907,-0.058994256,0.03424646,-0.00043013797,-0.004781619,0.079786114,-0.02801825,0.05977828,0.014960194,0.07649642,-0.050844938,0.039232217,-0.09876337,-0.007769922,-0.0063467463,-0.022341825,-0.01169183,-0.007143557,0.03804318,0.010788398,0.02528019,-0.01930392,0.063487895,0.05659555,0.055252414,0.015362995,0.0224929,-0.06158262,-0.0049210275,-0.00685874,-0.0402911,-0.003316222,0.00794543,0.08147612,-0.021749718,0.011336347,0.07647949,0.006598636,0.045160368,-0.047196772,-0.01070322,-0.022806503,0.005362899,-0.08307398,-0.095660225,0.061875965,0.018069237,0.043161288,0.077471495,0.0355537,-0.008378836,0.058118176,-0.008809291,0.070250444,-0.095714115,-0.03857521,-0.041658685,0.10927172,-0.047768008,0.06080282,-0.009764458,-0.049362313,0.02721806,0.01392051,0.03541308,-0.045762368,-0.011339305,0.03647944,-0.08210169,-0.009113025,-0.08108773,0.029440213,0.048607085,-0.02139606,-0.044088278,-0.021653663,0.040037826,-0.005085817,0.008884587,0.047246266,0.005793014,0.13536781,-0.01727657,0.03735874,-0.0367997,0.017717468,-0.034696456,0.025219157,-0.084628284,0.01105211,-0.023472069,-0.030721897,-0.06744736,-0.030349566,-0.027905043,0.013271121,0.043390367,0.018116519,-0.0070209466,0.03215943,-0.06557501,-0.1437871,-0.041551977,-0.039256994,0.066663474,-0.024237983,0.03830678,0.008524092,-0.0275739,0.05272852,0.020802634,-0.010810768,-0.059150036,0.11824227,-0.043531653,-0.025342276,-0.015994098,-0.034829568,0.0011119196,0.024252852,-0.02869917,0.13258898,-0.031932957,-0.025019476,0.02029131,1.8476868e-34,0.0054312455,0.007482756,0.025900349,-0.010751849,-0.035758782,0.03988877,-0.06185776,-0.040934805,0.057905775,0.0052032825,-0.10434233,0.0026649833,-0.005302199,0.09511513,-0.016487444,0.01956469,0.014916964,0.000881058,0.049111873,-0.021491326,0.022405524,0.16668375,-0.03054618,0.02259504,0.059418056,0.03643637,-0.053040408,0.074784346,0.108089924,-0.036361665,-0.040370226,0.040734462,-0.0304101,-0.008510955,-0.043641087,0.030646034,-0.049779132,-0.07008165,0.034365304,0.060749456,0.102340534,0.019426253,-0.05118999,0.016913867,0.005992777,0.04965701,-0.021091575,-0.055496458,-0.019978784,-0.033995584,0.056553897,-0.017057572,0.027500913,-0.020040203,-0.047717627,-0.0127161825,-0.030413397,-0.05631797,0.07009672,0.119033456,0.022232067,-0.016055707,0.000907253,-0.041794714,-0.031024808,-0.026728762,0.0026477666,-0.06577169,-0.00031399034,-0.022565162,-0.015656734,-0.000596183,0.07383603,0.035758853,0.035250418,0.01092087,-0.06362186,0.059079364,0.062197804,-0.023256747,-0.034582183,0.004551367,-0.04850372,0.034938183,-0.004078786,-0.013681867,0.010766689,-0.093780525,0.07329412,0.0017538789,-0.057939783,-0.07657676,-0.05670445,-0.0057871304,-0.0068905177,-1.7205042e-33,0.02628554,-0.038046047,-0.0023734209,0.048787124,-0.033310857,0.03871133,0.06317028,-0.028453214,0.05963259,0.005490086,0.07681908,-0.06496627,-0.019269528,-0.016110124,-0.0087096775,-0.022351792,-0.049535524,0.06504053,-0.031011911,0.06637588,-0.023548018,0.07821792,0.035144076,0.050405476,0.096599795,0.014351675,0.022925964,0.056663834,0.040866274,0.028256651,-0.0016904265,-0.03410913,-0.048883393,-0.08771638,-0.030023878,0.06814495,0.09252312,0.025106821,-0.10469982,-0.0844696,-0.0035352686,-0.020111691,-0.021406831,0.007728861,0.029713146,0.028813299,-0.04572442,-0.085567124,-0.110752776,0.020132245,0.105365954,0.02854098,0.023213226,-0.03092695,0.01716661,0.045576707,0.08336074,-0.036976878,0.03518422,0.0027723287,-0.062571906,0.017000187,0.019123167,-0.032420844,0.027281541,0.06967924,0.016246729,0.030499019,0.008995235,-0.032650013,0.0069079185,0.0065494934,0.13553607,0.091467865,0.08753887,-0.046777353,-0.075873174,-0.067964196,-0.009223583,-0.0828144,-0.0488338,-0.069290005,-0.0550396,0.008481074,-0.03435681,0.012110279,0.0893181,0.051330794,-0.033165365,0.0550699,0.009236424,-0.019019987,-0.069350205,0.04894986,0.05713106,-2.3637275e-08,0.049227644,-0.022312913,0.0018341924,-0.04679407,-0.014631349,0.0026014326,0.017050572,0.021457376,0.02450569,-0.061307438,-0.018423548,0.12705913,0.017218968,0.011467293,-0.016429555,0.054867897,0.0017750311,0.036547385,0.010101136,-0.056680556,-0.08770659,0.0652953,-0.07423996,-0.00904893,-0.019035358,-0.05776144,-0.0047365436,0.11324085,-0.008077675,-0.08728043,0.01936058,0.029493127,-0.026446931,-0.10246268,0.013241881,0.0479853,-0.005933778,-0.044486456,0.08283019,0.040334083,-0.07380603,0.07031393,-0.064633474,-0.012724406,0.018827599,-0.112374626,-0.016328122,0.027103642,0.04529975,0.020430213,0.021218313,-0.0030247932,-0.034036834,-0.16673064,-0.03485433,-0.032046165,-0.05651646,-0.08289293,0.02205324,-0.012681692,-0.084967755,-0.033429053,0.10265483,0.013988967 +2.4.1.17,"This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.",384,0.99999994,-0.04643674,-0.076505326,-0.033187844,0.009010617,0.06965821,0.065797895,-0.012464322,0.01577821,0.025597418,-0.053492088,0.053202383,-0.100707196,-0.10406392,0.025828425,-0.0026237655,0.010642988,-0.073448084,-0.04647245,-0.0075553036,-0.028766856,0.08301777,0.051995426,-0.0066512167,0.036581486,0.0046458016,0.0763651,0.01626316,-0.043825805,0.028002141,-0.05880105,0.013146007,-0.011151294,0.07164218,0.004716327,0.026762646,0.025740443,-0.07186735,-0.12207347,-0.00019745316,0.052929454,0.039200157,-0.054356858,-0.00475001,-0.05393689,-0.034049638,-0.022370726,0.018760413,-0.030363282,0.0019435647,-0.044027165,-0.0032321531,-0.051739767,-0.045475867,0.046462536,0.0067723687,0.040557466,-0.041723013,-0.022813989,-0.07542482,0.037854448,0.03780036,0.04085402,0.0029207596,0.009743243,-0.015301354,-0.025269711,0.03783048,-0.06902732,0.03841748,-0.007016178,-0.12323969,-0.117116936,-0.020121979,-0.006491497,0.04658264,0.02701176,0.039696988,-0.00883302,0.00082748244,-0.08638414,-0.015355553,0.056804083,-0.040623616,-0.031104745,0.013014939,0.017954642,-0.019435216,-0.05760087,0.081062555,0.04280454,-0.03463779,-0.09718041,0.0232315,0.002362916,-0.019536415,0.06949843,0.05030629,0.08899969,0.07238112,-0.04384453,0.008051777,0.06829711,-0.095509544,-0.03333445,-0.039316747,-0.020857891,0.03631422,0.08607073,0.034701254,-0.022129692,-0.0112904925,-0.07360306,0.05091217,-0.022261448,-0.03507517,0.06784464,0.00034253972,-0.034633014,0.042939518,0.0133802565,0.01660598,-0.008402275,0.087737896,0.056845106,-0.04954152,0.021534357,-0.117652446,-4.3611472e-33,0.06707478,0.022833401,0.008915868,0.00855865,-0.020927109,0.013193648,-0.10170746,0.08134087,-0.046369493,-0.051761165,-0.04513913,0.055233203,0.02463491,0.0408038,0.008545176,-0.06398845,0.019807342,0.07316382,0.09432024,-0.05368206,-0.03436712,0.046596155,-0.04186839,0.030913547,-0.02914226,0.04579788,-0.029036261,-0.036398917,-0.011616419,0.014685366,-0.019930372,-0.063886896,-0.057452723,0.007725392,-0.0126387,0.044705823,-0.041042402,-0.023842566,0.019318089,0.019410027,-0.009293225,0.0235919,0.01814739,-0.03870447,0.025948454,-0.0018671096,-0.019406293,0.10488703,0.05144696,0.019378318,-0.010544867,-0.068497136,0.16599756,-0.040109053,-0.044423893,0.06676438,-0.060639177,0.039602067,-0.023043169,0.030276679,0.011445982,0.1370012,-0.07655221,0.027295403,-0.053762328,0.050828747,-0.04735887,-0.017953908,0.0023165878,0.06108728,-0.08113768,0.07911127,0.075153425,0.045501154,0.12839018,-0.035337258,-0.02998718,-0.012289082,-0.03019462,0.023205826,-0.10237017,0.032200444,-0.016915618,-0.0072439634,-0.07655452,-0.027101869,-0.048430823,-0.00552958,0.04597603,0.030891355,-0.07871382,-0.04919625,-0.028419996,0.029086048,-0.03908451,9.074944e-34,0.08202744,-0.08719231,-0.05946234,-0.08778468,-0.02735412,-0.0015205638,0.014338483,0.007414073,0.0394649,-0.025751518,0.06345958,0.002346376,0.056118432,-0.13210602,0.0053776214,-0.051012564,-0.0990876,0.045387868,0.014740545,0.006464197,-0.023688668,0.025414607,-0.008687803,0.0077353297,0.08205004,0.013420901,0.012189779,0.047738973,0.045254584,0.05285295,-0.048420906,-0.009376776,-0.017142726,0.04179899,-0.019780727,0.023975292,-0.013954548,-0.020055294,-0.0024341939,-0.01937866,-0.015229132,0.057821296,0.015211758,0.08914121,0.047881983,0.10578398,-0.055690765,0.042824294,0.008520104,-0.083042376,0.019679919,-0.00511483,-0.050791416,0.028506994,-0.0087805325,0.10407361,-0.027621176,0.026549682,-0.01321539,-0.052476294,-0.018498275,-0.040006023,0.03711262,0.0021463963,0.019823223,-0.023178251,-0.107132226,0.038037773,0.033337124,-0.04525571,0.103448346,-0.046780158,-0.028703269,0.0107093435,-0.0368737,-0.07715317,-0.01985019,-0.09703463,0.007908314,-0.020836003,-0.015567817,0.033392455,-0.01478276,-0.041188035,0.027712876,-0.04522073,0.03386479,0.06235998,-0.02417086,0.035434753,0.010029893,-0.008949768,-0.030449536,0.12998207,-0.0028232443,-5.567328e-08,0.089760154,-0.005501314,0.072707735,-0.009575441,0.07114749,0.05837609,0.024475714,0.0025905943,0.06868346,0.02095451,-0.028368076,0.035885233,0.028398614,0.020222476,0.04220593,-0.015523539,-0.09266597,0.026509099,-0.019358201,0.022419838,-0.021916816,-0.01962385,-0.099633366,-0.030335035,0.017104002,-0.08143424,0.024900593,0.06289604,-0.04316716,-0.024369216,-0.009158486,0.051855817,0.034311797,0.03587321,-0.034097202,0.020596445,-0.007581051,-0.061657287,-0.073885545,0.06829996,-0.04497956,-0.10379437,-0.050894707,0.0053485753,0.03321119,0.050216325,0.00013321397,0.0819169,0.042589296,-0.032673802,0.005016953,-0.009856093,-0.005084035,-0.018240735,-0.0582564,0.021368062,-0.04060888,-0.100428164,0.0070332694,-0.08163506,0.09988905,0.063300885,0.19635297,-0.0126266 +2.4.1.18,"Converts amylose into amylopectin. The accepted name requires a qualification depending on the product, glycogen or amylopectin, e.g. glycogen branching enzyme, amylopectin branching enzyme. The latter has frequently been termed Q-enzyme.",384,1.0,-0.05173706,-0.04673525,-0.05855214,0.0074665677,-0.07584453,-0.017649816,0.029374853,-0.011046237,0.013652699,-0.03251521,-0.04102615,-0.01299884,-0.035728123,0.08471716,-0.053483833,0.039598417,-0.09675438,0.019135583,-0.013001378,-0.0380585,0.06832015,0.007220325,-0.0029757915,-0.01262213,0.0878865,-0.027669264,-0.05082068,-0.035378262,0.01295179,-0.04546066,-0.036060892,-0.012882074,0.015499753,0.03072481,0.035300083,0.07106808,-0.072225966,-0.047883496,-0.011183589,-0.03339827,0.03149828,-0.046835687,-0.021348434,-0.023241395,-0.025101136,-0.028510615,0.007327924,-0.0029645048,-0.03811878,-0.026178265,-0.053100467,-0.113119125,-0.07717186,0.06728367,0.022811301,0.053498637,0.0068543693,-0.0033191475,-0.025495488,0.053314578,-0.057587158,0.060380694,-0.008335088,0.0010752754,0.0071903183,-0.047526427,0.0406509,0.00656523,-0.011610918,-0.034811415,-0.073900566,-0.05231704,-0.043489195,0.032532778,0.07168149,-0.02356465,-0.030137992,0.06488671,0.030298512,0.030822767,0.0617207,-0.025258623,-0.005354411,0.009558637,0.037002128,-0.004257833,0.01710185,0.04445416,0.0064438693,0.0051950426,-0.010529105,-0.08915375,0.012387419,-0.048252888,0.06616477,-0.028568732,0.0057564666,-0.061464187,0.092771195,-0.057687696,0.0035735639,0.036437236,0.07009387,-0.08136983,-0.021614373,0.056764536,0.016500432,0.040118687,0.12298965,-0.043137185,-0.048391085,0.046658333,0.06970187,0.010217795,-0.023701916,0.06016266,0.0011007113,-0.024876885,0.0022784476,0.03354029,0.00050620805,0.011143356,0.086231284,0.055381317,0.0034033738,0.098384775,-0.15574549,1.1442465e-33,0.060996547,0.05433989,0.03535078,-0.015190938,0.0057874373,0.01873769,-0.055974435,-0.011242913,-0.0048012454,-0.048128866,-0.04738976,-0.12658496,0.015737554,0.11491286,0.057436455,0.039448682,-0.032262854,-0.04122778,0.03143009,0.03547246,0.018947849,0.05137458,-0.117161274,0.02464545,0.05307783,0.0661892,-0.026617235,0.050008986,0.06470751,-0.0082020955,-0.000675302,-0.08544162,-0.08576338,-0.011116537,0.006323138,0.09051141,0.002841451,-0.027600732,0.06148092,0.03012589,0.081219666,-0.0378093,0.031737503,0.026106514,0.05670765,0.017090779,0.00886746,0.02518878,0.004566075,0.04791151,0.030208461,-0.057459842,0.012771387,-0.040070824,-0.05167657,0.069659315,0.07090463,0.040793628,0.024638923,0.028447168,-0.013637681,0.03005255,-0.018876445,-0.004141737,-0.012263396,-0.004103098,-7.8364144e-05,-0.060952697,-0.11930055,0.08983387,-0.05906341,-0.08102902,0.0010670667,-0.01902532,0.056039628,-0.07270498,-0.01957779,-0.013089639,0.059545442,-0.08445752,-0.0065226923,0.06042701,0.0055948254,-0.062136017,-0.032828365,-0.08264111,0.009926194,-0.03315074,-0.0766292,0.022386229,-0.0017425525,-0.028213996,0.016317252,0.052796405,-0.0138685,-3.167084e-33,0.04986738,-0.08292497,0.034856338,-0.012638719,-0.03037173,-0.0010955767,0.03866053,-0.044988744,0.056365456,-0.04473054,0.051491737,-0.014868966,0.06890532,-0.020927241,-0.010041558,-0.01891674,-0.08216492,0.007895547,-0.004078253,0.042106893,-0.018840035,0.07764321,0.044419806,-0.030347371,0.057078,-0.003938714,0.05547841,0.1008393,0.049930234,-0.0360501,-0.105865195,-0.112110876,-0.05492181,-0.11838506,-0.13492244,0.0120411515,-0.011467209,-0.07685027,-0.025797939,-0.014043261,0.0132220555,0.032289058,0.034955014,0.048537243,-0.057354543,0.046063863,-0.009876115,-0.046331104,0.05046845,-0.026025001,0.03207025,0.027509829,-0.019972607,0.0328918,-0.043215435,0.011106148,0.01579859,0.0030696797,-0.07299288,-0.044475127,-0.051926654,-0.025167959,0.0958244,0.029626667,0.029528059,-0.0052919197,-0.004522537,0.05160181,0.033526972,-0.055603776,0.053152286,0.038784914,0.0356154,0.10669988,0.029282166,-0.05866769,-0.11964399,-0.016347772,0.030829538,-0.11016922,-0.008770736,0.016390463,-0.059396822,-0.0032193616,0.016355872,-0.103913546,0.06406334,0.12295944,0.03678342,-0.0044732154,0.025003731,0.020204656,0.020727031,0.055311676,0.0007782665,-3.135741e-08,0.0253097,-0.045709535,0.016943088,-0.064725995,0.03963242,0.002558751,-0.008661853,-0.05086368,-0.02395658,0.005641402,-0.08634042,0.095276825,-0.034689147,0.042766057,-0.00488516,-0.030738845,0.0015924337,0.08345578,0.0123257525,-0.022100775,-0.07861865,0.042295426,-0.10292392,0.069446854,0.034055978,-0.041116025,0.039468147,0.06481997,-0.04878524,-0.004167169,-0.035284173,0.09872796,-0.007259295,-0.044240415,-0.08801741,-0.014541488,0.02126387,-0.03523146,0.010857656,0.018575383,0.027213149,-0.03277054,-0.0021381583,-0.038345527,-0.06156762,-0.013515148,0.030336259,-0.024048721,0.09989873,0.057367813,0.10512994,-0.015554911,-0.033757992,-0.11220189,-0.030371036,0.0017821543,0.0104346415,-0.0075683026,0.06660365,-0.06196662,0.017269855,0.012354752,0.20636472,0.004034786 +2.4.1.19,"Cyclomaltodextrins (Schardinger dextrins) of various sizes (6,7,8, etc. glucose units) are formed reversibly from starch and similar substrates. Will also disproportionate linear maltodextrins without cyclizing (cf. EC 2.4.1.25, 4-alpha-glucanotransferase).",384,0.99999994,-0.0484176,-0.04802158,-0.07009766,0.015673773,-0.025692245,0.005889377,-0.033969626,0.030767458,0.02671795,-0.06094103,0.007673259,0.05679593,-0.05619608,0.005609826,-0.14324297,-0.05799079,-0.053597536,0.06760856,-0.019883193,0.08126842,0.07118731,0.015722282,0.013344705,0.1136619,0.12499747,-0.03221628,-0.0329915,-0.008587434,0.010355629,0.015129188,0.049290013,0.06611206,-0.036567304,0.005610427,0.082541734,0.056001987,-0.031230045,0.006956233,0.07058182,-0.06216898,0.052757233,-0.057488535,-0.048203576,0.024472645,-0.019691393,-0.055283546,-0.13404138,-0.0003249809,-0.017829014,0.072492,0.039567824,-0.08862357,-0.072249316,0.05485819,0.083798885,-0.025596568,-0.12413626,-0.024017625,0.04239306,0.005970984,-0.004652197,0.100276165,-0.09640482,0.047421128,-0.017940216,0.008707503,0.031853475,-0.04333464,0.009718493,0.030255849,0.0061892774,-0.04864247,0.04919001,0.037022687,-0.009560552,0.0024270085,0.008629624,-0.0514646,-0.07274428,0.054751437,0.023990145,0.0694706,0.10681644,0.09195466,-0.029026244,-0.03452588,0.037189,0.017673437,0.013029508,0.055604786,0.016021594,0.09824534,0.038614236,-0.06239279,0.017309763,0.015912632,0.022569723,-0.048664458,0.101486064,0.0032916917,0.010175369,0.0058617187,0.037552416,-0.013559354,-0.0076083443,0.028540503,-0.03186428,0.06297001,0.011269953,-0.012163993,-0.0046935314,0.01614288,0.0050220434,-0.0174872,-0.054157373,0.06271115,-0.02303396,-0.027083809,-0.006785286,-0.010579285,-0.023008019,0.004595058,-0.0230516,0.04115281,-0.015679313,0.084810615,-0.018162422,2.9669487e-33,0.05967595,0.005317389,0.032605715,0.041305892,-0.048937712,0.037232965,-0.035855636,-0.003948964,-0.031212576,-0.05519333,-0.099780396,-0.008536187,-0.0020661855,0.06384623,0.05968718,-0.03674416,-0.010150992,0.0025635448,0.0551955,-0.014139901,-0.075606786,0.04785412,-0.029569533,-0.058192022,-0.0274203,0.026972601,-0.08981132,0.03883104,0.027138066,-0.011697687,0.04935495,0.024782972,-0.0061160554,0.062437914,0.04514269,0.081355445,-0.020624988,0.0016913118,0.06722473,0.055326678,0.07816376,-0.008929523,-0.018717885,-0.06543675,0.08648353,0.005025573,-0.050167087,-0.047716323,-0.057962585,0.0035730184,0.048089605,0.036119133,-0.012444507,0.040054653,0.011330735,0.057210855,0.003940092,-0.0062217326,-0.017473433,0.041411564,-0.028145524,0.06295755,0.01064485,0.019409243,0.06278162,0.0060855052,-0.04909377,-0.057264943,-0.15764451,-0.073964424,-0.07316713,0.012741606,0.07462696,0.0033840926,0.05363903,0.014227365,0.05663874,0.094305515,-0.015658522,0.013069547,0.018505005,0.013787068,-0.014559572,-0.08586342,-0.051429518,-0.01636625,-0.024166374,-0.08799192,-0.057962183,0.007688279,0.010839022,-0.16434856,-0.06415073,-0.032981556,-0.08789005,-4.589644e-33,0.04105806,-0.074199796,0.063207164,0.004589717,-0.06169159,0.07915314,0.029471744,-0.09078116,-0.032288224,0.025731867,0.034024578,0.07482126,0.015559374,-0.06766745,-0.03694166,0.04535449,0.01271265,0.04549475,-0.040084984,-0.045809418,-0.011092558,0.101818025,0.02994374,0.026040632,0.10332527,-0.031104755,0.030021336,0.080453016,0.022255162,-0.026430354,0.018776538,-0.086084306,-0.0012359578,-0.06341338,-0.03258262,0.065090396,-0.04486683,0.0060266526,-0.035686046,-0.0065958276,-0.052726544,0.0042460747,-0.010825041,0.041879438,0.08917767,0.034860972,-0.05242192,-0.0258752,0.07621238,0.01128698,0.0180776,0.072955966,-0.05628635,0.06611026,0.029061332,0.01186373,0.06282901,0.029560473,0.0031341107,-0.031070175,-0.0068534072,0.0059209983,0.00045823256,-0.067483194,0.079921186,0.0006006372,0.011989773,0.06676101,-0.014377382,0.006718766,0.093566425,-0.04545539,0.026982177,-0.0034698301,-0.02683939,-0.042568777,-0.025993085,-0.030147264,-0.050139364,-0.051437873,0.06610609,0.009916085,0.085599594,0.0060698846,0.021737268,-0.067542806,0.08519916,0.03089266,-0.028567504,-0.016636413,0.033997547,0.0011855287,0.04768215,-0.008248255,0.12559783,-3.9843837e-08,0.07642899,-0.051536422,-0.059288587,-0.05118999,0.0024300318,-0.026323376,-0.0064839446,0.0013433058,-0.013268545,-0.061926585,-0.07284615,0.055391256,-0.044534817,-0.023357458,-0.009633023,-0.06441578,-0.07055318,-0.008764795,-0.04083084,-0.028743532,-0.14547704,0.023234192,-0.05609961,-0.010027379,-0.057972163,-0.11922168,0.08327252,0.042016514,0.02002838,0.0118004065,0.0050775255,0.047418263,0.0052838065,-0.045357365,-0.017639343,0.03623364,-0.055538602,-0.03772709,0.046214323,0.058888875,-0.056097664,-0.06206091,-0.006853959,0.013480548,-0.110868335,-0.036268204,0.009671208,-0.0018129289,0.014840653,0.04649597,0.038360354,0.019053254,-0.09521147,-0.08327245,-0.010333373,-0.024522103,-0.027676903,-0.010670296,-0.022004006,-0.023326678,-0.054342654,-0.039003447,0.121548265,0.02870699 +2.4.1.21,"The accepted name varies according to the source of the enzyme and the nature of its synthetic product, e.g. starch synthase, bacterial glycogen synthase. Similar to EC 2.4.1.11 [glycogen(starch) synthase] but the preferred or mandatory nucleoside diphosphate sugar substrate is ADP-alpha-D-glucose. The entry covers starch and glycogen synthases utilizing ADP-alpha-D-glucose.",384,0.99999994,-0.088945836,-0.062581584,-0.10233401,-0.028508127,0.011208648,-0.026903445,-0.013283654,0.031260915,-0.03536165,-0.012825275,0.019826744,-0.03084968,-0.09555621,0.0031639745,-0.07406018,-0.011932249,0.025480004,-0.0071845464,0.10865276,-0.021798419,0.0753119,0.010324455,-0.002982491,0.022170834,0.09073044,-0.011622211,0.04664828,-0.054984957,0.0062395935,-0.05730678,-0.057029665,-0.014688623,0.09592917,-0.040691804,0.05781313,0.071342446,-0.06672159,-0.07384515,0.02304079,-0.013863689,0.047734816,-0.05612992,0.0027443513,-0.02442399,-0.019403517,0.026193812,-0.033201616,-0.010029744,-0.002712318,0.0029670226,-0.021383045,-0.11278185,-0.06959677,0.009400864,0.059599724,-0.019534783,-0.028776962,-0.011701733,-0.014199144,0.08894083,0.008490901,0.071251765,0.0010855666,-0.03490649,0.039977603,-0.034525447,0.06298949,-0.067401744,0.0063753687,-0.030981714,-0.09005529,-0.053461242,-0.014986205,0.039651968,-0.02032996,0.009484554,0.027325122,-0.041150082,0.08252836,-0.025968768,0.03544842,0.032422964,-0.042665206,-0.021658385,-0.018391006,-0.029513197,0.041403987,0.042347856,0.067549035,-0.015709793,-0.045318965,-0.008958114,-0.042016122,-0.02032329,-0.026198078,0.07191631,0.009378321,0.015513491,0.07926819,-0.06746078,0.007209105,0.092456505,0.021842923,-0.031832628,-0.0036495908,-0.0017877475,0.021716932,0.021496255,0.03997817,0.052296937,0.019823411,0.05211601,-0.008738657,-0.042845394,-0.10351386,0.05609533,-0.025529709,-0.0666995,-0.0063244626,0.03695094,0.020725572,-0.014136454,0.06486784,0.06728228,-0.006870758,0.08924658,-0.057338506,-2.4372532e-34,0.09274138,0.07009174,0.010882253,-0.028110081,-0.019543674,0.021485673,-0.06419257,-0.0043582246,-0.01855423,-0.044277605,-0.04374072,-0.10093855,0.029771658,0.13842987,0.044085916,-0.043110605,0.008710718,0.02975337,0.04558108,0.011088374,-0.06895937,0.10269282,-0.019615302,0.02091577,0.056434516,0.021128062,-0.090625025,0.03805868,0.08274783,0.003154498,0.05352928,-0.051151276,-0.019781826,0.034905266,0.04115099,-0.03446399,-0.087923065,-0.056727346,0.06175446,0.0334091,0.052811418,0.009675095,0.04341171,-0.019633723,0.03769424,0.016926005,-0.022383923,0.03546786,0.024270384,0.008717425,-0.005722536,-0.013566396,0.05862545,-0.032188877,-0.01998348,0.05360373,-0.021545272,-0.014028345,-0.0029901443,0.086286016,-0.054912087,0.1400641,-0.01817287,0.045503642,-0.034681674,0.048201133,-0.042511754,-0.05333236,-0.04547425,0.012209959,0.00030167596,-0.0659699,0.055367693,0.074657254,-0.002362283,-0.06666296,0.0036653893,0.025674338,-0.00929228,-0.053983636,-0.0037164695,0.043002393,-0.053830072,-0.03764789,-0.10299245,-0.0008806065,-0.042744994,-0.029532196,-0.015894959,0.0014234285,-0.01978175,-0.01287688,-0.052034087,0.03471499,-0.043359917,-2.3236265e-33,0.1117464,-0.11161594,0.013655421,-0.07034233,-0.046914674,-0.012397356,0.04572989,-0.13162632,0.057422172,0.015913798,0.024832556,-0.019988045,0.021696346,-0.093911655,-0.0267966,0.030634472,-0.076205365,0.07869827,-0.06137419,-0.002781605,0.050544124,0.0668582,0.029717552,0.022947872,0.07866804,-0.05492954,0.027570175,0.104366325,0.028459763,-0.00280949,-0.042381734,-0.016290553,-0.030652193,-0.03388882,-0.06900095,0.043410733,0.035801213,-0.023097211,-0.023922803,-0.0060815415,0.0075473893,0.1247441,0.031093022,0.05980008,0.03301565,0.04834652,-0.033065103,-0.0048141433,-0.039768316,-0.04970217,-0.024452904,-0.024806766,-0.007654698,-0.011651306,-0.011897324,0.050687365,-0.039195087,0.06308507,-0.041515097,-0.05178022,0.009903567,-0.07331851,0.067644954,-0.051366672,0.017145718,0.056447655,-0.023378955,0.036598053,0.03208533,0.006255471,0.08993647,-0.006157827,-0.036488824,0.046281677,-0.056556553,-0.010121579,-0.018837944,-0.0129643595,0.01961451,-0.103135854,0.032397985,0.04098013,-0.030856516,0.035947327,-0.029368157,-0.020508999,0.06250018,0.103987984,-0.019747125,0.053570077,-0.0484273,-0.0024725418,-0.058124095,0.07807262,0.0491387,-3.8010384e-08,0.10744676,-0.07391608,0.057043776,-0.07255382,0.03768965,0.03506753,0.021712923,-0.04499843,0.07496546,-0.0073843617,-0.08000019,0.100442514,0.009991424,-0.03350458,-0.004015838,-0.0037719498,-0.059227314,0.07180933,-0.066920005,0.07190013,-0.066258036,0.047087885,-0.11242862,0.044865865,-0.0619796,-0.069180824,0.099029,0.02304677,-0.02992555,-0.031157335,-0.011989648,0.09947186,0.015308326,-0.09506785,-0.02804838,0.02179123,0.026691947,-0.040096816,-0.010041641,0.06056308,-0.022699343,-0.05618138,-0.0020825341,-0.013370343,-0.041037522,0.027990764,-0.023690237,-0.021309456,0.023042155,0.008098767,0.03346797,0.012548744,-0.061771378,-0.10430815,-0.039279055,-0.00020297305,-0.108442575,-0.04779181,0.006262352,-0.028875515,0.05091104,-0.008000296,0.20179428,0.021987036 +2.4.1.22,"The enzyme is a complex of two proteins, A and B. In the absence of the B protein (alpha-lactalbumin), the enzyme catalyses the transfer of galactose from UDP-alpha-D-galactose to N-acetylglucosamine (EC 2.4.1.90 N-acetyllactosamine synthase).",384,1.0,0.005622077,-0.09740631,-0.09029804,0.025758693,0.04883604,0.04899193,-0.005831569,-0.0053490475,-0.03557159,0.022846816,-0.025002828,-0.016906885,-0.054289013,0.00877777,-0.07163764,0.030014498,-0.046162173,-0.012287593,0.032966364,-0.0099286605,0.09490724,-0.0408634,-0.00036291016,0.02335892,0.0990817,-0.026389353,0.050576944,-0.08877787,-0.027891181,-0.11486165,-0.0015053331,-0.09567127,0.053427927,-0.005603795,0.029561358,0.048788093,0.01374518,-0.07295925,0.009532704,-0.044993475,0.044672843,-0.002832592,0.011786589,-0.011452629,-0.020511722,0.00080360303,-0.06584292,0.058438804,0.03680147,-0.0042476803,0.016179834,-0.08609415,-0.08437722,0.039508335,0.037724968,0.105255775,-0.043950554,-0.046886533,0.032609828,0.06428344,0.08213793,0.090916775,0.0142925065,-0.028803704,0.08587003,-0.08041953,0.05757892,-0.042609315,-0.025239825,-0.016381554,-0.0346635,-0.06248852,-0.07738483,-0.010502768,0.047913276,-0.03427444,-0.054317385,3.817156e-05,0.06498298,0.022963157,0.0240901,-0.012014186,-0.03280745,0.085794844,0.0047450033,-0.019488867,0.06817783,0.014877665,0.05232798,0.0013507308,-0.03238996,-0.0612384,-0.009555615,-0.029312316,-0.055575524,-0.043382935,0.001800376,0.021337802,0.063079536,-0.025130063,-0.0069672866,0.008514601,0.037817743,-0.08750207,-0.087006606,0.059022885,-0.025643349,0.07673078,0.06559388,0.023137461,-0.015409863,0.011553158,0.0647229,0.057138205,-0.028287068,0.120224476,-0.03373295,-0.085042074,-0.032590274,-0.020519534,0.06359944,0.010384778,0.07915148,0.06728601,-0.036605466,0.06604119,-0.042831324,4.245231e-34,0.05876718,0.028651828,0.03168689,-0.008714899,0.017236402,0.0366756,-0.08968579,-0.012185346,-0.012343126,0.0127771655,-0.0898399,-0.03389222,0.07021645,0.05185004,0.004147105,0.03203528,0.03176538,-0.03244286,0.057448708,0.018453397,-0.050837353,0.095383234,-0.08840885,-0.020966602,0.04250184,0.024325494,-0.018702235,0.0712687,0.06680416,0.021264847,0.006636251,-0.08831945,-0.10239732,0.05700951,0.020548124,-0.030868325,0.022170035,-0.0891739,0.03274758,-0.028629113,0.016210452,-0.00016677397,-0.016564418,-0.0017351088,0.023433339,-0.018749993,-0.03265821,-0.0035486375,0.042118173,0.02473749,0.03072148,-0.08202571,0.053302865,-0.022036472,-0.020080052,0.08857581,-0.059612367,0.024305198,0.046017475,0.0830979,0.04835334,0.048662756,-0.02215744,0.009180647,-0.0012876255,0.054708585,-0.011209616,-0.0316706,0.024347395,-0.013935657,-0.116721414,-0.056342367,0.059275847,0.0068588187,0.03072455,-0.063725546,-0.050460976,0.036525786,0.02317793,-0.008491083,-0.02860745,0.0010403551,-0.007927515,-0.022026349,-0.006523973,0.0063429107,-0.047981784,-0.060492206,-0.023756864,0.035355765,-0.014087526,-0.0408033,-0.021453466,0.087373376,0.03772999,-2.7013734e-33,0.09124186,-0.12752824,0.052850828,-0.06386907,-0.066193305,0.04665022,0.10807457,-0.07201897,0.058066353,0.0025379758,0.038278285,-0.039032277,-0.0045441836,-0.05484626,0.06286679,-0.015916657,0.02924233,0.04275799,-0.04847784,0.008861652,-0.013276967,0.08794446,-0.010395738,0.012214062,0.0011297762,-0.0076113087,-0.013427625,0.09270189,0.023379067,0.031079425,0.015333707,-0.03827834,-0.050614953,-0.099517025,-0.091140695,-0.00010247554,-0.00023592185,-0.0058595277,-0.043628193,-0.004427639,-0.022155683,0.08142333,-0.022463908,0.028815087,0.07761426,0.059056714,-0.050777633,-0.011513604,0.005706322,-0.03504753,0.03886175,-0.040969424,0.023246357,0.011842964,-0.046421073,0.04293034,0.037756246,0.035411023,0.026129209,-0.02102487,-0.033679597,-0.02604593,0.0629881,-0.040380467,0.03454258,0.002587228,-0.031101435,0.00977149,0.034311175,-0.030992467,0.017158844,0.026611455,0.02378718,0.12523852,0.0029481065,-0.017125752,-0.10367653,-0.06023103,-0.009170367,-0.11176123,0.038002174,0.06207902,-0.004345151,-0.031932782,-0.02379892,-0.033439077,0.0517126,0.14285114,0.016325435,0.0241842,-0.07429328,-0.008268603,-0.07430506,0.0036752243,0.09010948,-3.7114894e-08,0.05239372,0.021367539,0.012420531,-0.09311687,-0.009414231,0.011909554,-0.03602676,-0.025128366,0.059232455,-0.070516385,-0.07633638,0.1667227,-0.0032649038,0.05279736,-0.05513311,0.0010022231,0.032232113,-0.032379422,-0.012366321,0.027460089,-0.018255059,-0.01834279,-0.09052964,0.028244786,-0.020279313,-0.09657358,0.036470015,0.08993749,-0.029660841,-0.01669349,-0.0061673233,0.07336498,-0.017996747,-0.027379489,-0.03836187,0.04339298,0.010247258,-0.04364038,0.050431654,0.016661746,0.053605374,-0.033998195,0.017701652,-0.020986222,-0.015832841,-0.0017991338,0.005672042,-0.060255054,-0.022949891,0.06828436,0.026008695,-0.07192281,-0.10325695,-0.06787556,-0.039434988,-0.09792892,-0.06577542,-0.08847996,-0.0018508073,-0.054345943,0.030644048,-0.017802853,0.16521403,-0.06248578 +2.4.1.25,"This entry covers the former separate entry for EC 2.4.1.3 (amylomaltase). The plant enzyme has been termed D-enzyme. An enzymic activity of this nature forms part of the mammalian and yeast glycogen debranching system (see EC 3.2.1.33 amylo-alpha-1,6-glucosidase).",384,0.99999994,-0.07157498,-0.057609487,-0.045499135,-0.041139968,0.042343408,-0.034657285,-0.050683804,0.003709673,0.044875514,0.011531388,0.07565035,0.012264897,-0.11690599,-0.02407756,-0.04233464,0.00156218,-0.10636429,-0.0024552792,-0.019023437,0.009935261,0.049614903,0.047448795,-0.013330199,-0.0049414244,0.11487624,-0.03414123,0.036265727,-0.013240391,-0.033593055,-0.07952699,-0.04252704,-0.043952808,0.09172148,0.03583601,0.019937783,0.013561873,-0.022588428,-0.10126302,-0.040666524,0.025620176,0.023730548,-0.035746653,-0.00079549477,-0.02959822,-0.108050495,0.017048469,-0.02998633,-0.0052149976,0.013341375,-0.037423104,-0.009326147,-0.13574138,-0.029798025,0.022135928,0.030438764,0.026510723,0.014837264,0.05280204,-0.055813562,0.037441898,0.07582872,0.0241737,0.032697227,0.009522564,0.0391472,-0.051170122,0.016620226,-0.07617361,-0.00655576,-0.09979515,-0.05168767,-0.085282885,-0.0031882708,0.021467831,0.022612168,0.034265537,-0.014418366,-0.04592623,0.09160691,-0.07649285,0.052125927,0.02026483,0.03595579,0.020519055,0.011708844,-0.0018632245,0.017616948,0.024615642,0.020624137,-0.005869813,0.0038207343,-0.08500481,-0.0461963,0.02374536,-0.03169225,0.08104601,0.032754134,0.034166485,0.029296653,-0.04900251,-0.023679988,0.13575494,0.0033999668,-0.0712578,-0.030064322,0.047804743,-0.0010225732,0.03880946,0.011779131,-0.04085965,0.011160407,-0.0124526825,0.020123038,0.048531104,-0.023314003,0.01792754,0.03724517,-0.03623213,0.02129119,-0.01674587,0.046078827,-0.019678373,0.11664954,0.04300504,0.00016156935,0.084082365,-0.12142046,-7.1404605e-34,0.05612015,-0.014860645,-0.018335175,-0.0106005585,-0.00575342,-0.017283835,-0.051200032,0.023575738,-0.06986339,-0.020513844,-0.108078785,-0.07112508,0.033214398,0.061120573,-0.0039451956,-0.02463277,0.018448187,0.005933502,0.0799529,0.0045200977,0.06910072,0.044735897,-0.069066584,0.0018706997,0.06983686,0.01593537,-0.040333938,0.023742298,0.09291859,0.0053728744,-0.016992254,-0.113609456,-0.07462611,0.05686658,-0.0013378655,0.022369785,-0.015638074,-0.020527229,-0.021487834,0.041543584,0.06027472,-0.0069286423,0.051892295,-0.046492808,0.0042029265,0.032119907,-0.04163412,0.07603471,0.06280519,0.07376237,0.016134797,-0.03193877,0.12159977,-0.060271524,-0.016388323,0.025713256,-0.03182247,0.0014992931,0.03952034,0.06520346,-0.058220334,0.12293555,-0.04634103,0.047003426,0.0024182631,0.007617903,-0.075444095,-0.065658346,-0.052714225,0.09563838,-0.053435188,-0.09917472,0.07806617,-0.021865107,0.030304438,-0.061779667,-0.014900446,-0.018501882,-0.040464327,-0.019936498,-0.05184823,0.0015650566,-0.035524163,-0.0037825296,-0.03528319,-0.009810291,-0.03947595,-0.0020675699,-0.033056356,0.0033986408,0.0067405067,0.0075843288,-0.040888116,0.032235257,0.0009826116,-1.4154939e-33,0.09887645,-0.06924577,0.056715216,-0.08344962,-0.02082417,0.07426837,0.04682549,0.018932069,0.022765066,-0.020784875,0.074820824,-0.005166199,-0.015420205,-0.033629164,0.047811463,-0.007180576,-0.08597808,-0.010000997,-0.008362785,0.053679813,-0.045737512,0.08075011,0.012644046,0.04310236,0.039018642,-0.00059575815,0.032883983,0.07442281,-0.02875398,-0.04696462,-0.03086982,0.0036416468,-0.009876928,0.008846355,-0.092377,0.054042723,-0.08356318,-0.093377106,-0.008801306,0.027552089,-0.022574054,0.07642201,0.027032204,0.100364424,0.027159095,0.026987571,-0.013410439,0.053083036,-0.05746382,-0.026129892,-0.0029932328,-0.03038717,0.027395643,0.064986415,0.04262696,0.06580949,0.059621554,0.06476513,-0.057981815,0.024074625,-0.008361416,-0.052616455,0.054741964,0.008021751,0.05540405,0.001753833,-0.05640869,0.04620573,0.020127004,0.027617095,0.082943454,0.004317657,-0.01974911,0.044198055,-0.021425927,-0.076919734,-0.068903744,0.0039157127,0.042916358,-0.05460326,-0.026849926,0.040256824,-0.04367081,-0.0036646458,-0.014759491,-0.10942619,0.0003128523,0.14547363,0.027577683,0.038540874,-0.05051289,-0.012953909,-0.07472896,0.09520451,0.05048378,-3.8732754e-08,0.060934685,-0.0073321722,0.06544257,-0.07963382,0.088302515,-0.04945138,0.008772116,0.082028724,0.034238957,0.043279473,-0.05360355,0.110472366,0.008304166,-0.010102667,0.030122966,-0.0029900766,-0.012648804,0.068097085,-0.042508278,0.025682265,-0.019193651,-0.009917056,-0.17820959,0.006855582,0.010299471,-0.06828687,0.022814725,0.07467492,-0.077235624,-0.017385703,0.0154319545,0.052420273,0.010162979,-0.07262898,-0.08319314,0.009487329,-0.021289434,-0.05902167,-0.014118569,0.037382994,0.0076047494,-0.09316057,0.016148455,-0.010030843,-0.053118914,-0.014365979,0.0060337493,-4.7802564e-06,0.0620285,0.007304749,-0.015291086,-0.011868441,-0.05145163,-0.06936128,-0.07744053,0.009890546,-0.03950705,-0.06085286,0.011396025,-0.039452665,0.039621502,0.016411133,0.16991024,-0.009911441 +2.4.1.29,"Involved in the synthesis of cellulose. A similar enzyme [EC 2.4.1.12, cellulose synthase (UDP-forming)] utilizes UDP-alpha-D-glucose.",384,1.0,-0.07294273,-0.014273833,-0.06436628,0.0100121815,0.015328298,0.038672104,-0.042386137,0.05466367,0.05172898,0.066202074,0.019890111,0.005201485,-0.10790448,-0.014934044,-0.06073942,-0.062409583,-0.0016336769,0.03762549,-0.03956812,-0.03237575,0.060199976,0.022180509,0.020453876,-0.014986669,0.14062288,-0.028823717,0.07634727,-0.033622555,-0.04411468,-0.010699424,-0.0030054313,-0.022919217,0.05076903,-0.0061816024,0.07073698,0.124703534,0.036352858,-0.08735215,0.01382367,-0.05137148,0.07910446,-0.046192028,0.021042673,-0.0055115004,-0.017819516,0.007350307,-0.018657157,0.066709615,-0.049405016,-0.03509979,-0.020202355,-0.028819079,0.009486271,-0.034393236,0.03857682,0.025492126,0.012329904,0.03814078,0.033556715,0.0054605706,-0.060067095,0.047228504,-0.0013573166,-0.027153213,0.043183323,-0.07074713,0.046059083,-0.05971807,-0.08767769,-0.025366763,-0.05880807,-0.03690585,-0.07184066,0.042900436,-0.00814951,-0.0029207012,-0.023374762,-0.05970824,0.07679095,-0.010156224,0.1033182,0.03688418,0.040733654,0.029910678,-0.07451012,0.01061048,0.084091336,0.017640777,-0.004956263,-0.080222405,-0.0019706863,-0.011079375,-0.10042331,0.05730893,-0.08579203,0.062660955,0.061675508,0.06438938,0.08613494,-0.098778635,0.02195113,0.056615617,0.008105912,-0.12271839,-0.004898823,-0.020980926,-0.010273749,0.034539863,0.018680325,0.019303001,-0.0005428031,-0.013732709,-0.034391146,0.0038955295,-0.013847399,0.07161447,0.0042426516,-0.056450397,-0.061792124,0.01213553,0.013303467,-0.044540003,0.051104274,0.09528889,-0.05189335,0.06118314,-0.039423764,-4.5880992e-33,0.018720903,-0.02163109,-0.077275254,0.0065512764,0.010413127,-0.044456694,-0.041035138,0.027603008,0.00096572714,0.02988918,-0.050933983,-0.05138591,0.037793823,0.10572915,-0.043360658,-0.030911136,0.02768535,-0.07226003,0.04362993,0.026959622,-0.022812555,0.07350919,0.030198622,0.070434704,0.034635644,0.020837931,-0.06366727,-0.00060943,0.11723649,-0.031936854,0.04915726,-0.031353235,-0.093054965,0.004637541,-0.00739787,0.0035784235,-0.063597225,-0.017969346,-0.0048561366,0.037430026,0.028189648,0.010708612,0.046037454,-0.049676813,0.038086917,0.10117792,-0.06324185,-0.0020588588,0.08253605,0.027794944,0.09211647,0.105287574,0.04130292,-0.059182595,0.044553854,0.041350562,-0.028508555,-0.0082775755,-0.009246674,0.05175286,-0.020990891,0.10023855,-0.06271399,0.019941702,-0.083497904,0.010725327,-0.01114472,-0.030534452,0.0026764276,-0.034835584,-0.07031667,-0.0542098,0.06647752,0.027200138,0.027981171,-0.011642587,-0.047412965,0.0030473657,0.06654532,-0.07461815,-0.03266364,0.061564025,-0.020559374,-0.04560687,-0.012273229,-0.08719313,-0.094245136,0.049350817,-0.027442863,0.031119388,0.017039932,-0.008077259,-0.09760302,0.052166518,0.056654297,2.7471654e-34,0.07088479,-0.04080167,-0.031002719,-0.04229231,-0.024630884,-0.034849912,0.02041613,-0.09440274,0.071774356,-0.015788002,0.08293112,-0.012700895,-0.014750966,0.028430719,0.018406134,0.016479224,-0.14956822,0.09760351,-0.04831226,0.0035193914,0.0017691271,0.0682909,0.06832851,0.059139874,0.06905871,-0.021303358,-0.0015215103,0.08250215,0.06448583,-0.029799627,0.01994675,-0.042569883,-0.009350901,-0.035146073,-0.0594621,0.047453914,0.009688032,0.0023290766,0.017162992,-0.006972615,0.003779137,0.04438838,0.011845427,-0.012562269,0.04619304,0.02705991,-0.0148041835,0.010769944,-0.050424274,0.0004849208,0.0060254545,0.06682711,-0.0031426258,-0.022995071,-0.010422316,0.049049262,0.03170235,0.013219546,-0.01711143,-0.03605289,-0.030430067,-0.04720407,0.107868336,-0.028667081,0.04952922,0.08730419,-0.03253058,-0.015894866,0.040187642,0.03787625,0.07558556,-0.0097126635,-0.038176756,0.020798225,-0.023754735,-0.06307469,-0.08675508,-0.015238063,-0.0048877397,-0.054772284,0.008913321,0.07785058,-0.004043875,-0.0013007696,-0.014128123,-0.03990173,0.06636327,0.038653784,-0.029132897,0.04418947,0.018000687,-0.039357275,-0.008722746,0.04691895,0.079006985,-3.004949e-08,-0.027553778,0.013972643,0.04866554,-0.09251278,0.034582324,-0.043903183,0.014454551,0.04378811,0.055385854,-0.051981155,-0.061806157,0.14819951,-0.03915438,0.030255863,0.03135854,-0.023996256,-0.050444204,-0.018177304,-0.026434528,0.022335105,-0.018953927,-0.015167867,-0.14941327,0.07063567,-0.05636973,-0.105040394,0.008858754,-0.02537159,0.020379474,0.017064542,0.01496171,0.06628393,0.021057934,-0.06689398,-0.09175779,0.007729609,-0.034926016,-0.10610095,-0.022905333,0.031455465,0.017967923,-0.10702646,0.0045492463,-0.034222078,0.0060868864,-0.0042882655,-0.009578089,-0.07073373,-0.0099196285,0.023649517,-0.025629692,-0.027247883,-0.04196297,-0.11154383,0.018382164,-0.017626328,-0.08891351,0.034608033,0.04243207,0.002312262,-0.06217529,0.0029376345,0.17040032,-0.04536019 +2.4.1.30,"Does not act on laminarin. Differs in specificity from EC 2.4.1.31 (laminaribiose phosphorylase) and EC 2.4.1.97 (1,3-beta-D-glucan phosphorylase).",384,1.0,-0.07663487,-0.13487989,-0.07428664,-0.057448495,0.029126238,0.014971856,-0.055244893,-0.027020471,0.069538325,-0.046429027,0.049367394,0.021451754,-0.12599124,0.06267039,-0.07168167,-0.02628673,-0.03385432,-0.012944563,-0.024017338,0.05158702,0.024086254,0.03399497,0.029455708,0.08243522,-0.0051047406,-0.031114336,0.0036355427,0.001482532,-0.019812811,-0.026919208,0.096924536,-0.004898711,0.017680027,0.0032250101,0.10448779,0.0025682556,-0.05949882,-0.053193007,-0.033939674,0.00012994552,0.10263089,-0.04957516,-0.011930554,0.011042215,0.046603795,-0.06271027,-0.04284251,0.011779756,0.017606724,0.023260688,-0.01786344,-0.028738027,-0.05547025,-0.013604282,0.0029720874,0.10429944,-0.06050446,0.0058546816,0.05427928,0.066723354,-0.05871872,-0.02509346,-0.031120865,0.05251186,-0.010854083,-0.008016762,0.057465587,-0.1414593,-0.016741732,0.0082525145,-0.011310073,-0.055627163,0.04850685,0.05202295,0.05897791,0.02683713,0.0015356409,-0.027753765,-0.006458696,-0.04041876,0.02680966,-0.034027845,0.044980817,0.012457094,-0.06533616,-0.000919489,-0.002569947,-0.04249006,0.02392007,0.020640524,0.0994218,-0.024530942,0.004865808,-0.03266983,-0.06564258,-0.008051178,0.023720989,0.058371883,0.04185375,-0.06765744,-0.04781547,0.014520862,-0.09000171,-0.082374066,0.01146739,0.055085495,0.056455743,0.05774033,0.0015285943,-0.04957034,0.013274076,-0.051261537,-0.009586679,0.011927597,-0.023588166,0.001365691,0.11967906,-0.12102125,-0.010678459,-0.033180486,0.0020271395,-0.08490321,0.08961969,0.014534193,-0.13436176,0.04977755,-0.08951337,-2.578691e-36,0.040122967,-0.083154224,0.03269272,-0.038261026,-0.025145,0.0095214965,-0.0830388,-0.07629667,-0.013312205,-0.12828247,-0.005022601,-0.0420234,-0.005721831,0.10613283,0.064018585,0.088159725,0.010620836,-0.026521923,0.06558559,-0.00581608,0.08623027,0.09210919,-0.013450735,-0.015451528,0.083921224,0.031126428,-0.07941075,0.041056663,0.05016201,0.023867177,0.035944246,-0.059044126,-0.06397814,0.010283654,0.016272211,0.14003505,-0.022518327,0.0067750607,0.03701269,0.017331474,-0.0650315,-0.0025670512,-0.0026305113,-0.055961475,0.036860734,-0.074998155,-0.0042054574,0.04180832,0.0063111912,0.032444812,0.0153981745,-0.018631054,0.119367816,-0.015885953,0.06407683,0.017082406,-0.0177686,0.017759968,0.0655516,0.035857666,0.018895209,0.037344284,-0.036757793,-0.023053203,0.007118823,0.066923864,-0.037231963,-0.01738646,-0.03827766,-0.022013765,-0.009626988,0.026720466,0.07024056,-0.023360556,0.0848529,-0.02510004,-0.043008175,-0.00018936103,-0.053968385,0.032567017,-0.02847243,0.021233454,0.06198334,0.05434487,-0.053921748,0.058213368,0.060183868,0.0066759433,-0.012647424,0.07661175,0.042488564,-0.043047775,-0.006008811,0.0991241,0.0060147904,-2.3019724e-33,0.049480285,-0.047919177,0.021050025,0.012695002,-0.032850415,0.040309105,0.049301967,-0.04819743,0.039559428,-0.068207525,0.0715738,0.0034043547,-0.1056915,-0.016300011,0.034153342,0.013244461,-0.09668083,-0.008997258,0.0086952,0.012011044,-0.0167513,0.0016410226,0.034781072,0.10469028,0.112341985,-0.03082354,0.059481848,-0.0054438794,0.009774494,-0.0495407,-0.14192651,0.029296272,-0.033037,0.013332662,-0.0310902,0.05566678,0.0063872715,-0.01782101,-0.0059621767,-0.02931195,0.018797373,0.047875002,0.012976849,-0.01590462,0.009182014,0.07207715,0.06843107,0.06847942,-0.07394727,-0.032435037,-0.033281542,0.018200131,-0.012135989,0.086778365,0.06800675,0.020016434,0.12580116,0.05718206,-0.026033202,-0.04759101,-0.08333143,-0.0090332525,-0.033503003,-0.046681218,0.10941892,0.062662296,-0.004648623,0.057707597,0.01362893,-0.035594996,0.022429472,-0.053134024,0.040309623,0.021487894,-0.029731221,-0.033055637,-0.05076972,-0.045336742,0.02578111,-0.029322328,0.027642354,0.049846824,-0.033816583,-0.0056685093,0.015935848,0.023725348,0.04792369,0.002057164,-0.07044387,-0.012275506,0.027129333,-0.014700145,-0.045344815,-0.010832555,0.054082062,-3.4603257e-08,0.06364756,0.055956233,-0.0017443018,-0.11287663,0.05444125,-0.008639533,0.0443229,0.00398266,0.03831322,0.06333506,-0.011533753,0.057087228,0.078771636,-0.03886263,-0.025693845,-0.026675107,-0.070811614,-0.05585018,-0.0067721577,-0.04202815,-0.06656558,-0.0044041346,-0.11478448,0.02274366,-0.08164889,-0.12635212,-0.0480634,0.04113335,-0.039816596,-0.026388649,-0.010120375,0.019285863,-0.03071125,-0.027435718,0.025430474,-0.008251532,-0.038935546,-0.04749165,0.012338663,0.098146886,-0.040335853,-0.0341075,0.041201048,-0.017498769,-0.050139934,-0.014384973,0.056261145,-0.03433036,-0.013218065,-0.008536064,0.043052573,-0.04983743,0.0006531554,-0.059196133,-0.073533714,-0.029743696,-0.009737367,-0.10222748,0.025401475,-0.017049782,0.06505704,-0.0053671305,0.0646027,0.010418934 +2.4.1.31,"Also acts on 1,3-beta-D-oligoglucans. Differs in specificity from EC 2.4.1.30 (1,3-beta-oligoglucan phosphorylase) and EC 2.4.1.97 (1,3-beta-D-glucan phosphorylase).",384,1.0,-0.046983574,-0.08429377,-0.018984798,-0.03009472,0.05407447,-0.0185939,0.030778626,-0.03172272,0.10393034,-0.011137958,0.02287254,0.025540778,-0.09576696,0.05429174,-0.041356765,0.017987935,-0.06536514,-0.016049216,-0.03359763,-0.05644606,0.056942277,0.04060999,0.06481088,0.054246534,0.0042640865,-0.055791546,0.04460365,0.0046406025,-0.01836301,-0.09852477,0.015365435,-0.08246738,0.04099007,0.045962222,0.03186072,0.0016267399,-0.056539685,-0.07188316,-0.058979116,0.0696201,0.09474656,-0.008764617,0.009538935,0.024056515,-0.060760956,-0.00967939,-0.08445137,0.021025779,0.02821207,0.02423514,0.006936251,-0.103439406,-0.08541024,0.063218504,0.053183373,0.063382685,-0.1543316,0.023455586,0.030822923,0.07930284,-0.012179892,0.022622008,0.02303981,0.06433168,0.020650273,-0.004375344,0.086872905,-0.092479214,-0.046965305,-0.016443899,-0.018484063,-0.03816353,-0.02227474,-0.039477304,0.06878024,0.01400701,0.004817228,0.0032371003,-0.00931287,-0.08711715,0.043910198,-0.027900944,0.05420692,0.004380648,-0.07558963,-0.051839795,-0.08052976,0.000397352,0.042854726,0.015514429,0.059427902,-0.08474774,0.017784843,0.018935012,0.018606706,-0.009967233,0.062151458,0.06812254,0.036875892,-0.017332561,-0.056682963,0.052879903,0.016997928,-0.022705806,-0.0040567643,0.06946892,0.0043946356,0.059689067,-0.02714594,-5.640913e-06,0.028073262,-0.10317754,0.088452466,-0.01596278,-0.08741737,0.030719584,-0.02952849,-0.058269355,0.02963232,-0.030290814,0.05043024,-0.0761672,0.06727484,-0.00752572,-0.123543255,0.13757855,-0.12114164,-3.695769e-34,0.07423316,-0.020690983,0.0006360534,-0.037433002,-0.012076839,-0.0075558797,-0.05647368,-0.015490937,-0.08710952,-0.07817963,-0.033973828,0.022158008,0.008417078,0.11056041,0.04288325,0.0855744,0.015236011,0.04136144,-0.00048080474,0.025713699,0.035302553,0.0730356,-0.06740881,-0.01806275,0.06647889,0.0063718036,-0.10713915,0.06833144,0.028769055,-0.0072090914,0.03374145,-0.045728594,-0.091755815,0.04308151,0.015867889,0.041413914,-0.01984122,-0.05616897,0.0128786545,-0.028406631,0.0036115826,0.00434131,-0.02324026,-0.024166571,0.06460988,-0.034026768,-0.012140668,0.052612554,0.026877075,0.078676544,0.0389723,-0.0024593556,0.074712776,0.009520096,0.036756124,0.023893079,-0.0021758345,-0.01696168,0.05179747,0.02289782,-0.005053819,0.08414069,-0.014923195,0.00415324,0.018928967,0.048105508,-0.097521365,-0.017967582,-0.0741735,0.040616844,-0.015986532,-0.013554681,0.044372894,-0.031552617,0.055206146,-0.06471505,-0.027052328,-0.033509664,-0.09446251,0.036990985,-0.028491555,-0.020369243,0.019015472,0.03831236,-0.10703566,0.062013965,0.05318321,-0.02479634,-0.0028570849,0.07940388,0.0037717724,0.0073173735,-0.10161589,0.10959455,0.016576042,-1.543326e-33,0.061395485,-0.05175977,0.026183654,-0.017022502,-0.061100833,0.08298994,0.076073214,-0.025402004,0.06465457,-0.03234591,0.07419566,0.01454838,-0.06677925,-0.06787989,0.045292497,-0.09196412,-0.08006362,0.06867104,-0.031315267,0.042370245,0.016359394,0.055119243,-0.03934376,0.06737012,0.05594206,-0.0701918,0.032787926,0.058922663,-0.05561594,0.013192411,-0.06330655,0.01944096,-0.010380298,0.02560215,-0.036207706,0.02437547,0.0058644833,-0.07192418,-0.0026739093,-0.020065749,0.013521624,0.031843256,0.024086354,0.032367107,0.037505224,0.16863458,0.03567536,0.06697511,-0.05600457,-0.033472028,-0.038207352,0.018964583,-0.010981995,0.05289243,0.07622282,0.045404952,0.05666234,0.02874396,-0.000950579,-0.045434725,-0.012457844,-0.055495866,0.054356057,-0.052045766,0.06560008,0.009611606,-0.028962528,0.035889927,0.05652114,0.04257555,-0.009466828,-0.05989422,-0.009668833,-0.0022740394,-0.030518949,-0.011283672,-0.0894594,-0.047695536,0.0044217715,-0.03732141,0.008534172,0.007650458,0.06553094,0.032552537,0.007938173,-0.0026158467,0.066329956,0.09880222,-0.05599489,0.06478474,0.004642662,-0.012884655,-0.055132747,0.040963326,0.0025237787,-3.666395e-08,0.06365622,0.018700255,-0.0019356596,-0.085053444,0.013292187,-0.023889402,0.024514718,0.082785726,-0.0009869072,0.056905527,-0.025198555,0.06512638,0.042599928,-0.021600356,0.058905117,-0.00018917126,-0.037037972,0.0085901115,-0.010488081,0.010913938,-0.05150671,-0.011295821,-0.042886354,0.010463874,-0.07387457,-0.10668393,0.04881876,0.098418646,-0.04218325,-0.03066729,-0.018655494,-0.015084905,0.006860717,-0.07826965,-0.011782393,-0.022630459,-0.07772197,-0.021451494,0.028863017,0.051120326,0.0014592336,-0.066154994,-0.012862283,-0.006899795,-0.05975448,-0.013792361,0.017084304,-0.040402602,-0.0237549,-0.0146060735,0.0059649027,-0.042167377,-0.04037248,-0.055602714,-0.09193152,-0.060884748,-0.053422686,-0.046642136,0.002400281,-0.06419977,0.07654114,0.00071831944,0.09478726,-0.013499201 +2.4.1.33,"The enzyme catalyses the polymerization of beta-D-mannuronate residues into a mannuronan polymer, an intermediate in the biosynthesis of alginate. It is found in brown algae and in alginate-producing bacterial species from the Pseudomonas and Azotobacter genera.",384,1.0,-0.015984775,-0.04292186,-0.022866929,-0.051357802,-0.047411837,0.069280244,0.006405227,-0.012632406,0.021524655,0.12859839,0.0409651,0.0014262924,-0.05866693,0.004179055,-0.1198936,0.07461016,-0.07118463,0.07559447,0.004764376,0.07164449,0.13325687,0.07598548,0.052098338,-0.00045501677,0.08047064,0.010473355,0.01881986,-0.089354135,0.015709763,-0.05793576,-0.034723327,0.0069707227,-0.02698545,-0.061411962,0.11870576,0.037666246,0.026697814,-0.064937964,0.12655768,-0.007194963,0.0915519,-0.037581265,0.02013002,-0.032598052,-0.045688316,0.051469233,-0.028522162,0.117741495,-0.008361891,-0.05850056,-0.052707933,-0.052775547,0.018672096,-0.02732438,-0.004545488,0.035366576,0.03261354,-0.007748316,0.010411031,0.05981054,0.029001541,0.02643008,0.07049044,-0.007565203,-0.033589974,-0.060823955,-0.0019379681,-0.032978464,0.035599753,0.015644064,-0.030211316,-0.07418082,-0.022043664,-0.0015651302,0.069062725,-0.04994081,0.07434567,-0.15412202,-0.022719726,-0.010139439,0.016322387,-0.018721022,0.10286214,0.03505934,0.0044333995,-0.040921673,0.032277383,0.06611055,0.040484767,0.014123018,-0.06593494,-0.0005915984,-0.034056276,-0.08872833,-0.08147268,-0.010987255,-0.0030985945,0.06042484,0.092449404,-0.013081645,0.0033033823,0.037348058,0.022460625,-0.18882048,0.016658878,0.012192022,0.03823108,0.014832068,0.014123743,-0.036536492,0.002751884,-0.0005367336,-0.018024078,0.007241501,-0.10031451,0.041535694,0.066047505,-0.10237431,-0.07031945,-0.006632761,-0.060417134,-0.073491,0.0013814708,0.056846377,-0.06115474,-0.009692187,-0.102716394,-6.677388e-34,0.03206075,-0.022735002,-0.00085750595,-0.025714185,0.05797688,0.018801035,-0.01802438,-0.09258206,-0.056533907,-0.0898683,-0.11572311,-0.10757124,-0.0481256,0.08550404,0.004460926,0.03790585,-0.031071372,-0.0053550326,0.016414566,-0.04287653,-0.0013755183,0.058685362,-0.06317163,0.03814899,0.106081426,0.055799995,0.015497106,0.011132258,0.040928964,-0.031325076,0.060576476,-0.026338134,-0.07499756,-0.017666157,0.031436067,0.035707492,-0.052188657,-0.012256731,0.028520549,0.05439611,0.024165522,0.038462043,0.028490733,-0.017437669,0.01749329,0.04360762,0.031979293,0.09881934,0.0748143,0.0075466284,0.017172514,0.052985426,0.045072567,0.00030777056,-0.07251188,0.023090493,-0.07572047,-0.029637955,0.084237516,0.07132395,-0.03638522,-0.027490607,-0.01881561,0.010962649,0.0123077715,0.008014137,0.04880747,0.045405217,0.056895323,-0.045111246,-0.074562654,-0.06367359,0.071175024,-0.007475541,-0.002814323,-0.002639431,-0.0598819,-0.07790131,0.004721859,-0.017960416,0.05947375,-0.0043263757,-0.06655721,-0.06939575,-0.029822016,-0.0090291,-0.042039666,-0.0033064361,0.029337179,0.031232275,-0.026424386,-0.05384954,-0.07289602,0.0032458834,-0.029276928,-1.5474625e-33,0.056212395,-0.07787809,0.079591244,-0.00022698821,-0.057365432,-0.026153043,0.012375676,-0.0059283655,-6.203234e-05,-0.025587583,0.05786528,-0.033189945,0.061166085,-0.015650332,-0.04709843,-0.00053695845,-0.012136096,0.047053225,0.0013664889,-0.020517027,-0.004381213,0.08670274,0.020037066,0.017864607,0.00954412,0.009791587,-0.059657283,0.035386935,0.028587209,0.098324515,-0.010800221,0.012362607,-0.028031036,-0.054277513,-0.042750686,0.030494433,-0.02897134,0.0051128734,0.010679066,0.051093675,0.012678399,-0.017578505,0.004049089,0.0016634485,0.047077876,0.06188183,-0.020683864,-0.008816867,-0.045124404,-0.037076693,0.028350405,0.012107431,0.06415076,-0.010844625,0.016806891,0.052320752,-0.011645097,0.023417866,-0.006069181,-0.0059914384,-0.04408222,-0.049876824,0.121929325,-0.04839085,-0.00018037563,0.06588377,-0.032901186,0.04899021,0.036302533,-0.050917543,0.05897351,0.101859935,0.0029263142,0.07931587,-0.009066535,-0.018103736,-0.08569373,-0.07496694,-0.018916056,-0.06455844,-0.018506251,0.0071988106,-0.018253952,-0.0026100145,0.0013711378,-0.010398324,0.105014086,0.09516614,-0.102157116,0.037080515,-0.059749246,0.009610886,-0.040561657,0.09359224,-0.009425091,-2.9821535e-08,0.01342556,0.033178486,0.09378407,-0.057754025,0.040533658,0.03758435,0.021504674,0.05437986,-0.002364382,-0.03327722,-0.040687196,0.06180846,-0.007995797,0.022811389,0.05060507,0.004019206,-0.05188412,-0.011641827,-0.048200347,-0.06096189,-0.05038962,0.060643237,-0.056024164,0.059707668,-0.047996853,0.04886773,0.033635456,0.021171672,-0.06322752,0.020181375,0.014392861,0.092277534,-0.013548844,-0.04791983,-0.020086674,0.015966302,-0.044095036,-0.0770037,-0.0010308228,-0.053879954,-0.00060279365,-0.032849792,0.02217671,-0.0033771028,-0.032377485,-0.0014809192,-0.0041149706,0.027249709,-0.009961541,0.06992294,0.10016578,-0.02922517,-0.03863129,-0.059888456,-0.09540405,-0.0062760883,-0.02502372,-0.06570663,-0.025329435,-0.014903388,0.008295201,-0.07883774,0.13905485,-0.04156238 +2.4.1.35,Acts on a wide range of phenols.,384,0.99999994,-0.02117833,-0.10227365,0.039017063,0.0070109554,0.011611748,0.064627975,0.028519299,0.023869045,0.041260444,0.05559748,0.03695685,-0.06332276,-0.17407173,0.07664294,0.041213155,0.086564295,-0.04985826,0.092569634,-0.080924146,0.03226477,0.042074624,0.018329237,0.044821747,0.043133166,-0.12618199,0.006394536,-0.045017432,0.022417655,0.024188485,-0.10250918,-0.0028808753,0.036433883,-0.0071490286,0.030486077,-0.044086725,0.058639072,-0.033622466,-0.10666298,0.056009255,0.036310673,0.119258836,-0.06277417,-0.0072678546,-0.011385799,-0.069797896,-0.037650503,-0.032997403,0.0304966,0.02156857,-0.06959512,-0.07986243,-0.044848226,-0.025361879,0.06756578,-0.087353334,0.11855834,-0.066700056,-0.023320366,0.050858032,-0.02029853,-0.0056831865,0.016912373,-0.015493747,0.018539693,-0.05985561,0.02626532,-0.056624334,-0.018783992,0.07267569,0.02465761,-0.03239498,-0.0473817,-0.044935077,0.007990791,0.044024866,0.064293765,-0.006582535,-0.0019196083,-0.04065768,-0.045211125,-0.026310826,-0.0043311873,0.004548332,-0.021325154,0.10462215,-0.052500833,0.016959326,-0.0049303886,0.008739013,0.09857383,0.008394955,0.003453383,0.023986207,-0.029933456,-0.08836304,0.038159087,0.10520647,-0.050522592,0.035875686,0.03868981,0.02023106,-0.002441532,-0.0011305425,-0.036391042,-0.049001653,-0.03242917,-0.058109593,-0.03437984,-0.034357008,0.0134051405,-0.025637386,-0.033724733,0.011361246,-0.03750193,0.010179212,0.015820647,-0.06100668,-0.023125604,-0.022443233,-0.054065295,0.008824453,-0.08092629,-0.00627264,0.028830476,-0.04061322,0.043379772,-0.12005355,-2.1884935e-33,0.123315215,-0.036687642,0.04974041,0.04878014,-0.0072572096,0.04080295,-0.09665004,0.017783506,0.0077905925,-0.08528044,-0.04452656,0.059373606,0.025405299,0.021456247,0.02528837,-0.02435656,-0.05042585,0.042718064,0.052761998,0.013428648,-0.042283002,0.03197456,-0.100411616,0.006390235,-0.024755932,0.051991597,-0.05828525,-0.065390915,-0.06587175,0.029974436,0.058313746,-0.057725944,-0.050020404,0.08199929,-0.06263186,0.11158472,-0.07946534,-0.093646765,0.009386576,-0.06640801,-0.015160992,0.00047883618,0.008329769,0.04173668,0.028704828,0.0068415324,0.0014712815,0.04968632,-0.024732025,0.053467244,0.02621288,-0.027207099,0.09724014,0.03240341,0.02557431,0.073850855,0.019110385,-0.014700713,-0.010046538,0.016928028,0.066194735,0.08515293,-0.04112756,0.03673913,0.002460532,0.07507574,-0.09895462,0.015467623,-0.0035120824,0.047943138,-0.026073653,0.0348433,0.060446545,-0.064770766,0.02253783,-0.03207656,0.024941988,-0.03328413,-0.027175745,0.07744476,-0.071429595,-0.020740876,-0.003861885,-0.008219473,-0.10244638,0.024684746,0.013984338,-0.033203106,-0.01659482,0.0148102045,0.047301106,-0.090354785,0.015567218,-0.0059544076,-0.03935384,1.383288e-33,0.029318502,-0.04276605,-0.0044695837,0.109357275,0.0112458505,0.019992467,-0.06456063,0.028453311,-0.014393365,0.041484866,-0.03823771,0.012845037,0.05435416,-0.086559385,0.0057752864,-0.01880922,0.06655812,0.0063981744,0.03390211,0.005920652,-0.03497945,0.06567983,0.06895878,0.08623221,0.001977884,0.038073085,-0.018506978,-0.046060957,-0.015352252,-0.0151143335,0.004729383,0.014995326,-0.06668755,-0.05333073,0.031377748,0.0054105073,-0.020436257,0.004858903,-0.0014237654,-0.023497252,0.03785011,-0.039515276,0.037392806,0.08732166,0.010135582,0.09074574,0.014746956,0.028996687,-0.07339211,0.0021062586,-0.06724139,0.116414055,-0.08146677,0.005177761,0.001046632,0.051289517,0.016841302,-0.09082729,-0.035717055,-0.05763431,-0.017305985,-0.04420144,-0.049285043,0.006544358,0.021438802,0.03296513,-0.051050488,0.095561504,0.022315321,-0.023724545,0.10651418,-0.033739638,-0.0084267445,0.0011184787,-0.038249,-0.047863156,-0.026191004,-0.14381665,0.030904775,0.0140824765,-0.06312937,-0.0361816,0.026313886,-0.048480768,0.009830051,-0.006337411,-0.02814698,0.0017343631,-0.012194763,0.07484905,0.030619321,-0.005372886,0.0025040982,0.018138994,0.043789256,-1.9326185e-08,0.074833885,0.016468864,0.064154446,0.019475369,0.02422703,0.021265207,-0.018095667,0.05153416,0.05271401,0.07999726,-0.042271573,-0.05614536,0.08327016,0.054439116,0.16252956,0.04724801,-0.05499431,-0.0094723,-0.08482839,0.019474957,-0.08954778,-0.023816383,-0.012292953,0.026336566,-0.042493146,-0.025823342,-0.0022355705,-0.0016905288,-0.04315181,0.03543952,0.029409505,0.0008691058,-0.00545163,0.08756751,-0.007502073,0.052743487,-0.0014282953,-0.060186617,-0.06458727,0.04375362,-0.096839555,-0.096483245,-0.03979951,0.09579557,-0.015906187,0.043300014,0.007929285,-0.0139680905,0.0747611,0.037556197,0.044146776,-0.013594113,0.03186292,0.007835554,-0.11103765,0.04490808,0.029630236,-0.03392517,0.019076068,0.0082622785,0.01666924,0.03128466,0.03452764,0.06595954 +2.4.1.36,"See also EC 2.4.1.15 [alpha,alpha-trehalose-phosphate synthase (UDP-forming)].",384,1.0,-0.07407163,-0.054106172,-0.06622769,-0.06570455,0.025603704,-0.017843451,-0.010443043,0.04817272,-0.02500226,0.008586641,0.07320284,-0.04155729,-0.076308645,0.035476673,-0.06515695,-0.03868683,-0.06032401,-0.037326716,0.058060706,-0.062042437,0.048814204,0.05054793,-0.028504962,0.0048141116,0.0425434,0.044556715,0.08369702,-0.046241526,0.02224426,-0.086060114,-0.022663904,-0.027698908,0.07202185,-0.06840428,0.05012258,0.091595545,-0.06745083,-0.067019545,-0.010440283,0.04384013,0.10982466,-0.04433527,0.022434859,-0.0071552666,0.017842157,-0.028004851,0.0034548366,0.030171657,-0.040438384,-0.0037084762,-0.0059186574,-0.07217002,-0.014113192,0.0074838153,-0.008896196,0.013819262,-0.08612021,0.028763544,-0.04523746,0.03513737,0.06396177,0.026335204,0.01533745,-0.02235953,0.002198034,0.022961235,0.082321525,-0.044883102,-0.016845316,0.02128714,-0.09090802,-0.009688783,0.0012673237,0.052824695,-0.04039871,0.08625855,0.02095024,-0.07977267,0.07757769,0.0025801405,0.034140196,0.0145766875,-0.057632636,0.029418122,0.0012083421,0.031234553,0.026005948,-0.016802765,-0.03951581,0.030531108,0.009469957,0.008886107,0.033445887,0.05617559,-0.060490683,0.09855238,-0.034138646,0.090805754,0.039327074,-0.07688791,-0.050595008,0.06627229,-0.055936147,-0.039956614,-0.06148142,-0.071807675,-0.009095373,0.014051524,-0.003605081,0.07036131,-0.013097022,-0.019454397,0.056979537,-0.03152347,0.03034077,0.08479096,-0.04317025,-0.030243339,0.0449544,0.01325882,0.04662249,-0.033762172,-0.0053338544,0.082651936,-0.02128401,0.0030411712,-0.07487235,-2.2365185e-33,0.10185444,0.10544151,0.026595421,0.006815613,-0.0071922233,-0.004785771,-0.10719901,-0.0049886745,-0.1115425,-0.028377583,-0.04359833,-0.0439864,0.045357496,0.035979375,-0.029042553,-0.107938774,0.010005372,0.07650946,0.010308884,-0.035257977,-0.014805904,0.08591623,-0.0285497,0.0066442867,0.01105165,0.016994588,-0.09719449,-0.006087193,0.11630703,0.0073002386,0.0048390976,-0.03927429,-0.12433697,0.009607242,-0.004015279,-0.057227753,-0.0596658,-0.03453237,-0.00028082094,0.035983086,0.04668373,0.025025481,0.050291546,-0.009011907,0.08164681,-0.059273634,-0.10838061,0.04386012,0.087348476,-0.035073653,-0.0021711185,-0.014607431,0.075302646,-0.03307791,0.02838812,-0.011355452,-0.055427704,0.002993696,-0.021740308,0.06966311,0.003865941,0.1523305,-0.068687156,-0.009819415,-0.10559073,0.011330691,-0.01150866,-0.08705196,-0.001599498,-0.0033906042,0.008136826,0.00492285,0.07955614,0.0037653716,0.04907717,-0.030771831,-0.033674937,0.06782903,-0.020398837,0.010225511,-0.10670034,-0.011830162,-0.0032721038,0.014591372,-0.005268639,-0.06998528,-0.0036500504,0.050629877,0.052072518,0.06697012,-0.0076171053,-0.038046,-0.11995566,0.02879828,-0.036377892,1.3143738e-33,0.07022643,-0.060634974,-0.033740986,-0.02766659,-0.076646514,-0.0032274865,0.043970354,0.011397959,0.11425807,-0.027040802,0.10822638,-0.040920522,0.019124791,-0.08908651,0.04507644,-0.062947765,-0.024404084,0.04834394,-0.017475056,-0.031961188,0.033839192,0.062023085,0.011833599,0.07875527,0.086813636,-0.007157246,0.026598036,0.08419853,0.013422295,0.014244212,-0.019014487,-0.024381846,-0.049148165,0.016911425,-0.11235733,-0.01598203,0.027717702,-0.020817436,0.007257486,-0.055100426,0.030913262,0.046325315,0.019438202,0.068031885,0.053966016,0.07368491,0.07617046,0.039538875,-0.036148503,-0.0016010265,0.03121925,-0.021455986,-0.019477578,0.019797271,-0.0214908,0.0481116,-0.021599026,0.06717225,0.039615232,-0.0053853695,0.043599274,-0.082572974,0.055356454,-0.062266946,0.029523522,0.017159268,-0.035789594,0.047768023,0.029309632,0.0051462813,0.02565478,0.0015538926,-0.012579239,0.03751378,-0.008261664,-0.034252744,-0.110461496,-0.038381997,0.06660577,-0.07747385,-0.042624347,0.039280362,-0.018240497,0.030703597,0.05703804,-0.0030038906,0.05860693,0.08598271,-0.016069181,0.07285759,-0.09281307,-0.023138994,-0.06843671,0.09965341,0.059983224,-2.7843717e-08,0.075043306,-0.0021452548,0.033580065,-0.0615407,0.037915595,0.0031682786,0.04624441,0.032394446,0.11734677,-0.053374328,-0.059388865,0.04359967,0.04924926,-0.0027904464,0.07044322,-0.012849137,-0.0061452626,0.030937115,-0.039430946,-0.07392863,-0.0026173044,-0.012372003,-0.09815763,0.0132482415,-0.0144084245,-0.03630257,0.04860925,0.015919475,-0.006636136,-0.038238067,0.004047701,0.0059609697,0.0871204,-0.03217508,-0.010100252,0.08119105,-0.045406755,-0.04231353,-0.039645873,0.05392766,-0.05961471,-0.09274117,-0.02160573,0.0076990966,0.01051198,0.017804679,0.011181488,0.047684927,-0.01782701,-0.06733033,-0.0066896947,-0.038236547,-0.008275731,-0.09243911,-0.044893555,0.007879895,-0.023579484,-0.062075857,0.036642306,-0.013412593,-0.02259551,0.0017438568,0.15203121,-0.001918382 +2.4.1.37,"Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.",384,1.0,-0.0051491857,-0.08095021,-0.06649495,0.03657905,-0.007093903,-0.047817986,0.03243601,0.035383157,0.08762357,-0.010908065,0.09261981,-0.018656997,-0.10981431,0.08966566,-0.04183107,0.01841321,-0.045601297,0.02572994,-0.0154923685,0.03856507,0.07607742,-0.05965768,0.01506952,-0.0034853516,-0.028764583,-0.0057774573,-0.0049142237,-0.02703475,0.0044134646,-0.09176717,-0.0050363285,0.026041212,0.039918166,0.02850806,-0.061499923,-6.1570563e-06,-0.036336686,0.016417507,-0.008926144,0.015495016,0.029175095,-0.111663304,0.039242245,-0.017160397,-0.0034382443,-0.054244004,-0.013334866,0.07862678,0.07022153,0.05430312,0.006554934,0.0031861882,-0.086830296,0.08212441,-0.028161103,0.053121816,-0.13442184,-0.055868942,0.012789257,-0.013168442,0.03899727,0.005167369,-0.055403654,0.06899004,-0.012961505,-0.06489436,0.052846055,-0.026882857,-0.033173863,0.011974218,0.06277717,-0.03384506,-0.0057284487,-0.039826803,0.101511404,0.085963644,-0.019612,-0.04423754,0.055908564,0.03864659,-0.0023914406,0.054248158,0.046820045,0.064981796,0.048119683,0.037293505,-0.044442017,0.04742933,-0.11863896,0.034976713,0.023604063,-0.019433038,0.048794176,-0.0379086,0.029823903,-0.0023998166,0.024534717,0.010259314,0.0934884,0.005260002,-0.048629787,-0.017014768,0.014703534,-0.03507283,-0.026074287,-0.009137053,-0.026490094,-0.032364406,0.02824774,-0.034823775,-0.019729251,-0.07648728,0.078972325,-0.06154102,-0.027091853,0.077749014,6.7136374e-05,-0.025191132,-0.011653535,0.019081112,0.001446166,-0.015803818,0.0015835816,0.016399333,-0.00454609,0.059610903,0.00042722753,-9.598688e-34,0.031331163,0.009817705,0.056937218,0.042691786,-0.0067899604,0.013085798,-0.025498096,-0.08204571,-0.0058784685,0.027692795,-0.077611744,-0.032241307,0.058926817,0.118675426,-0.0018854736,0.0034997824,-0.015637223,-0.06278387,0.06081344,-0.03438317,0.019518225,0.13886969,-0.059082136,-0.061737936,-0.04652175,0.04123176,-0.10737336,0.071047224,0.05935856,0.024984688,0.04048348,-0.029318262,-0.050267447,0.035064973,-0.014579646,0.098946914,-0.041789506,-0.056876313,-0.011594541,-0.07591484,-0.006469346,0.051532377,-0.115380436,-0.002204295,0.053240057,-0.058746945,-0.060530607,-0.04644936,0.0044402485,0.075405724,0.04740904,-0.017658558,0.013149267,-0.02866147,0.0036527968,0.016398333,-0.013557997,0.032434706,-0.01616203,0.10870061,0.022673404,0.10766625,-0.025798477,0.025296133,-0.028582485,0.03583116,-0.04448083,-0.07037184,-0.02110595,-0.020103857,-0.045556158,-0.004310878,0.0023405354,-0.039935965,0.0028695473,-0.0352362,0.0146397995,0.0010589919,0.009353489,-0.031381764,-0.055978272,-0.10406737,0.013465884,0.07969586,-0.08342737,0.013335512,-0.02665091,-0.11678326,0.010296337,-0.017638866,0.0053261924,-0.035174493,-0.051400587,0.011424227,0.061931085,-2.0611179e-33,0.05395798,-0.08002119,0.03486677,0.02441941,0.007129755,0.064696126,0.019005118,-0.07590136,0.09330562,0.015784668,0.03565482,0.009128161,0.027338693,-0.050310094,-0.007286737,0.020291196,0.015566208,0.043765876,-0.048662808,0.06361727,-0.05923904,0.11630018,0.077499546,0.05092115,0.021685684,0.0033079886,0.014459039,-0.101486385,0.01429163,0.040566552,-0.005349128,0.0011691141,-0.053016435,-0.10901216,0.016571028,-0.08096987,0.010893184,0.027529754,-0.008098712,-0.058506485,0.05492101,0.02410852,0.0698605,0.11765404,0.061235055,0.07022372,0.03187573,0.008005246,-0.054017633,-0.04400279,-0.059509907,-0.019124236,-0.038057845,0.08864535,0.07121192,0.060102753,0.06496554,-0.106750816,0.0028822608,-0.009596695,-0.07471534,-0.045616876,0.0016057134,-0.072672054,0.07989167,-0.0205317,-0.08563803,0.051417008,0.004879174,-0.008097481,0.08904511,-0.014512856,0.00083361287,0.02635584,-0.012634231,-0.0267418,-0.12807637,-0.11898228,-0.000970651,0.0043615703,-0.053683072,-0.007104327,0.0073981327,0.041374605,0.024887042,-0.12106789,0.043191396,0.047356628,-0.04293653,0.021961963,-0.013290738,0.0068299877,0.030023606,0.00014206614,0.00047458612,-2.8096167e-08,0.037089568,-0.06923842,0.031036891,-0.0676556,-0.08947227,0.011421317,-0.025904601,0.03851206,0.016243182,0.02214085,-0.011331965,0.17763695,0.030704563,-0.03742483,0.06778638,0.08122614,-0.028469486,-0.03877764,-0.046825737,-0.082392246,-0.06895338,-0.05014628,0.02389805,0.0032124696,-0.031232849,-0.023855586,0.020464312,0.031061374,-0.025519505,-0.011520751,0.049094964,0.023914188,-0.056503452,0.015620263,-0.067245975,0.028390892,-0.0019650618,-0.016542364,0.019168815,0.054058436,0.041897584,-0.050633844,-0.046374377,0.012161294,-0.049859546,-0.010987254,-0.0065154936,0.026434671,-0.07456716,0.02059293,-0.0036298442,-0.03593344,-0.057714876,0.035877936,-0.068103395,-0.03191532,0.0042049023,0.036504917,0.08370728,-0.08438871,0.007435834,0.030567141,0.12626529,-0.019493882 +2.4.1.38,"Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. High activity is shown towards such residues in branched-chain polysaccharides when these are linked by beta-1,6-links to galactose residues; lower activity towards residues linked to galactose by beta-1,3-links. A component of EC 2.4.1.22 (lactose synthase).",384,1.0,0.048711836,-0.13923606,-0.046217926,0.029266892,0.041637108,0.052265976,0.017294686,-0.010353827,0.06331636,-0.00027569078,0.039403465,0.09135585,-0.040604487,-0.02854732,-0.09142111,-0.056463964,0.0070186467,0.015083543,0.0074242004,0.0024522247,0.07264924,-0.043723345,-0.044296667,-9.880472e-05,0.085103504,-0.056121387,0.0072879526,-0.11280773,-0.024133505,-0.07758795,-0.034530718,-0.07833847,0.017859837,0.026916314,-0.005403202,0.030203838,0.046435554,-0.04119737,0.034568604,-0.046514094,0.051115658,0.020215891,0.047768053,-0.052251805,-0.035478145,-0.011528684,-0.040521704,0.03989123,0.045090917,0.008547943,0.0029974233,-0.1043098,0.0181509,-0.022166785,0.055284422,0.043596163,-0.039205898,-0.049625125,0.06718936,0.09127711,0.022158112,0.03455978,0.05019422,-0.044490192,-0.066006385,-0.08971518,0.08818441,-0.046480015,-0.067611165,0.04971303,-0.0970724,-0.0050814906,-0.04383296,-0.039457407,0.082756445,0.023150045,-0.0752759,-0.04635953,0.035672765,0.012171093,0.018630272,-0.014785003,0.03714514,0.021919694,-0.05047775,-0.009701135,0.03920774,0.033775985,0.04326982,-0.008547287,-0.013266213,-0.082731195,0.04445258,-0.010603644,-0.01564326,-0.04202851,0.05329068,-0.018492082,0.049713258,-0.06164054,-0.038484585,0.010243231,0.09773885,-0.045627642,-0.054758333,0.080796264,0.013338602,0.07128588,0.08991938,0.009973015,-0.033831384,0.032871936,0.027468197,0.00018391552,-0.10174321,0.030454986,-0.00948638,-0.10474894,-0.034247216,-0.028373474,0.02526427,0.0070464527,0.06829037,0.038237184,-0.046467684,0.02958804,-0.011606349,1.0108855e-33,0.07020744,0.07034582,0.10232107,-0.039299376,0.038946968,-0.03341692,-0.041119847,-0.048427716,0.028517902,0.035162892,-0.068133555,-0.057878636,0.005538904,0.11185123,0.019439345,0.06436902,0.04279854,-0.042848773,0.06259856,-0.025677929,-0.0820338,-0.027097268,-0.0156128,-0.06259355,0.09815268,0.05346007,-0.028162833,0.09258875,0.0803937,0.011785209,0.059959866,-0.047562145,-0.054056276,0.11169115,0.08337588,0.017250203,-0.010570424,-0.008035711,0.03322068,0.008820084,0.036673147,0.012887018,-0.0141780935,-0.040895175,0.0027193602,0.035177067,0.011304348,0.022734717,-0.024786806,0.0950549,0.013142793,-0.015346582,0.003021781,0.031112894,0.0018715155,0.044818062,-0.06966342,-0.014326851,-0.0062925606,0.0790022,0.008162829,0.020252857,0.011771804,-0.06194735,0.015765209,0.09076925,-0.04418873,-0.0010575738,-0.011651158,-0.033321466,-0.07283758,-0.08270301,0.027024563,0.045890115,0.00033470851,-0.03674293,-0.072949454,0.017914025,0.03416677,0.009603985,-0.026929041,0.025297796,-0.047185455,-0.009720377,-0.052054703,0.008133235,-0.029957997,-0.06028228,-0.0077359625,0.021777209,-0.005081221,0.013953309,-0.0033868153,0.12405676,-0.006032772,-3.834941e-33,0.1079441,-0.110416934,0.06999352,-0.039541278,-0.051950745,-0.04176864,0.014939928,-0.07384673,0.02553823,-0.03301015,0.041356258,0.008047716,-0.050131667,-0.04507557,0.0018710428,-0.022029394,-0.05048912,0.084033914,-0.054901667,0.020803174,0.020217685,-0.0017280931,0.037908655,-0.011489475,0.04282791,-0.0071337074,0.037515122,-0.004890324,0.029193068,0.018609952,0.009424076,0.011938605,-0.030815188,-0.09902918,-0.064638145,-0.04612363,-0.10026836,-0.011931966,0.03754277,-0.046299286,0.03533064,0.08684292,0.024575153,-0.012667714,0.09780481,0.041909423,-0.013398349,-0.0016131011,0.012338765,-0.06735677,-0.031149147,-0.02680906,0.027601453,0.038450994,0.0667471,0.08799376,0.06956422,0.06954979,0.068341516,-0.07243301,-0.0707356,0.01818362,0.056154575,-0.05095045,0.04809104,-0.0054870746,-0.02860022,-0.014519314,0.06705828,0.0046813595,-0.015274012,-0.060608026,-0.013360591,0.07495268,-0.0068516084,-0.054338202,-0.17103745,-0.07168716,-0.056173004,-0.03628887,0.008488969,0.04848688,-0.047201637,-0.033175632,0.038503252,-0.042946544,0.03684743,0.10117324,-0.0032006933,0.027043168,-0.050802384,-0.0057184407,-0.013646197,0.08282913,0.04091191,-3.6460786e-08,0.048476882,0.02171554,-0.05859327,-0.11842672,-0.03512956,0.017061353,-0.056191508,0.029528223,-0.021858985,-0.004745651,-0.033235703,0.119861014,0.009638358,0.0033807382,-0.055479497,0.04178937,-0.035576005,-0.03610801,0.011028229,0.046190195,-0.10225572,0.018745396,-0.07972947,0.016164888,-0.0015832961,-0.10909046,0.05876121,0.09980249,-0.0758381,0.0010727907,0.019754527,0.089604445,-0.06252647,-0.06838871,-0.008518797,0.00780276,-0.05923091,-0.032665715,0.06955345,0.008196137,0.021913229,-0.025468295,-0.004126063,-0.033867314,-0.036567405,0.03925009,0.015499655,0.011636076,-0.074198335,0.084876485,-0.026975319,-0.042750217,-0.06720541,-0.060052805,-0.020669425,-0.009262307,-0.02735179,-0.05992113,0.02107629,-0.026350431,0.016795043,-0.058345184,0.0853895,-0.05051257 +2.4.1.40,"Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.",384,1.0,-0.0051491857,-0.08095021,-0.06649495,0.03657905,-0.007093903,-0.047817986,0.03243601,0.035383157,0.08762357,-0.010908065,0.09261981,-0.018656997,-0.10981431,0.08966566,-0.04183107,0.01841321,-0.045601297,0.02572994,-0.0154923685,0.03856507,0.07607742,-0.05965768,0.01506952,-0.0034853516,-0.028764583,-0.0057774573,-0.0049142237,-0.02703475,0.0044134646,-0.09176717,-0.0050363285,0.026041212,0.039918166,0.02850806,-0.061499923,-6.1570563e-06,-0.036336686,0.016417507,-0.008926144,0.015495016,0.029175095,-0.111663304,0.039242245,-0.017160397,-0.0034382443,-0.054244004,-0.013334866,0.07862678,0.07022153,0.05430312,0.006554934,0.0031861882,-0.086830296,0.08212441,-0.028161103,0.053121816,-0.13442184,-0.055868942,0.012789257,-0.013168442,0.03899727,0.005167369,-0.055403654,0.06899004,-0.012961505,-0.06489436,0.052846055,-0.026882857,-0.033173863,0.011974218,0.06277717,-0.03384506,-0.0057284487,-0.039826803,0.101511404,0.085963644,-0.019612,-0.04423754,0.055908564,0.03864659,-0.0023914406,0.054248158,0.046820045,0.064981796,0.048119683,0.037293505,-0.044442017,0.04742933,-0.11863896,0.034976713,0.023604063,-0.019433038,0.048794176,-0.0379086,0.029823903,-0.0023998166,0.024534717,0.010259314,0.0934884,0.005260002,-0.048629787,-0.017014768,0.014703534,-0.03507283,-0.026074287,-0.009137053,-0.026490094,-0.032364406,0.02824774,-0.034823775,-0.019729251,-0.07648728,0.078972325,-0.06154102,-0.027091853,0.077749014,6.7136374e-05,-0.025191132,-0.011653535,0.019081112,0.001446166,-0.015803818,0.0015835816,0.016399333,-0.00454609,0.059610903,0.00042722753,-9.598688e-34,0.031331163,0.009817705,0.056937218,0.042691786,-0.0067899604,0.013085798,-0.025498096,-0.08204571,-0.0058784685,0.027692795,-0.077611744,-0.032241307,0.058926817,0.118675426,-0.0018854736,0.0034997824,-0.015637223,-0.06278387,0.06081344,-0.03438317,0.019518225,0.13886969,-0.059082136,-0.061737936,-0.04652175,0.04123176,-0.10737336,0.071047224,0.05935856,0.024984688,0.04048348,-0.029318262,-0.050267447,0.035064973,-0.014579646,0.098946914,-0.041789506,-0.056876313,-0.011594541,-0.07591484,-0.006469346,0.051532377,-0.115380436,-0.002204295,0.053240057,-0.058746945,-0.060530607,-0.04644936,0.0044402485,0.075405724,0.04740904,-0.017658558,0.013149267,-0.02866147,0.0036527968,0.016398333,-0.013557997,0.032434706,-0.01616203,0.10870061,0.022673404,0.10766625,-0.025798477,0.025296133,-0.028582485,0.03583116,-0.04448083,-0.07037184,-0.02110595,-0.020103857,-0.045556158,-0.004310878,0.0023405354,-0.039935965,0.0028695473,-0.0352362,0.0146397995,0.0010589919,0.009353489,-0.031381764,-0.055978272,-0.10406737,0.013465884,0.07969586,-0.08342737,0.013335512,-0.02665091,-0.11678326,0.010296337,-0.017638866,0.0053261924,-0.035174493,-0.051400587,0.011424227,0.061931085,-2.0611179e-33,0.05395798,-0.08002119,0.03486677,0.02441941,0.007129755,0.064696126,0.019005118,-0.07590136,0.09330562,0.015784668,0.03565482,0.009128161,0.027338693,-0.050310094,-0.007286737,0.020291196,0.015566208,0.043765876,-0.048662808,0.06361727,-0.05923904,0.11630018,0.077499546,0.05092115,0.021685684,0.0033079886,0.014459039,-0.101486385,0.01429163,0.040566552,-0.005349128,0.0011691141,-0.053016435,-0.10901216,0.016571028,-0.08096987,0.010893184,0.027529754,-0.008098712,-0.058506485,0.05492101,0.02410852,0.0698605,0.11765404,0.061235055,0.07022372,0.03187573,0.008005246,-0.054017633,-0.04400279,-0.059509907,-0.019124236,-0.038057845,0.08864535,0.07121192,0.060102753,0.06496554,-0.106750816,0.0028822608,-0.009596695,-0.07471534,-0.045616876,0.0016057134,-0.072672054,0.07989167,-0.0205317,-0.08563803,0.051417008,0.004879174,-0.008097481,0.08904511,-0.014512856,0.00083361287,0.02635584,-0.012634231,-0.0267418,-0.12807637,-0.11898228,-0.000970651,0.0043615703,-0.053683072,-0.007104327,0.0073981327,0.041374605,0.024887042,-0.12106789,0.043191396,0.047356628,-0.04293653,0.021961963,-0.013290738,0.0068299877,0.030023606,0.00014206614,0.00047458612,-2.8096167e-08,0.037089568,-0.06923842,0.031036891,-0.0676556,-0.08947227,0.011421317,-0.025904601,0.03851206,0.016243182,0.02214085,-0.011331965,0.17763695,0.030704563,-0.03742483,0.06778638,0.08122614,-0.028469486,-0.03877764,-0.046825737,-0.082392246,-0.06895338,-0.05014628,0.02389805,0.0032124696,-0.031232849,-0.023855586,0.020464312,0.031061374,-0.025519505,-0.011520751,0.049094964,0.023914188,-0.056503452,0.015620263,-0.067245975,0.028390892,-0.0019650618,-0.016542364,0.019168815,0.054058436,0.041897584,-0.050633844,-0.046374377,0.012161294,-0.049859546,-0.010987254,-0.0065154936,0.026434671,-0.07456716,0.02059293,-0.0036298442,-0.03593344,-0.057714876,0.035877936,-0.068103395,-0.03191532,0.0042049023,0.036504917,0.08370728,-0.08438871,0.007435834,0.030567141,0.12626529,-0.019493882 +2.4.1.41,"Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.",384,0.99999994,-0.0337738,-0.06721458,-0.044155877,-0.013567894,0.07244751,-0.034047626,0.027190948,0.101598226,0.05695517,-0.0058537717,0.07927483,0.028602974,0.037392918,0.041133072,-0.04715991,-0.022349395,-0.0229497,0.03834067,0.010587928,0.02706543,0.138319,-0.0015865166,-0.011836013,-0.044458415,0.02717556,0.0075804796,-0.030982144,-0.0018805718,0.057265773,-0.025536673,-0.07607407,0.05861446,0.024647119,-0.035108283,0.0095910905,0.091661595,-0.01740785,-0.007668854,0.044738524,-0.025475161,0.026168266,-0.012634774,0.06729937,0.014343112,-0.027307723,-0.0501722,0.07050885,-0.028386887,0.0021651506,0.12843165,-0.0031301142,-0.0562697,-0.027113106,0.08514988,0.013318434,0.0013700954,-0.09077711,0.038872305,0.040632427,-0.01149813,-0.029291615,-0.051934745,0.010937045,-0.0075715617,-0.0335056,-0.089299306,0.03972518,-0.048837528,-0.019264711,0.032483414,0.0065450673,0.0107912645,-0.026377177,0.0052498933,0.04885637,0.0761298,-0.05840743,-0.007872565,0.02288172,-0.009925958,0.04392233,0.008246322,0.10451743,0.058805317,0.033002216,0.069906965,0.04341899,0.039533645,-0.0722997,-0.020527098,0.06664221,0.002803179,-0.023683805,-0.05351682,0.010127633,-0.0036761032,-0.021981783,0.002523717,-0.0010290539,0.01081822,-0.018590609,0.036503173,-0.016189069,-0.038926885,-0.010649997,0.016670618,0.017165003,-0.00032880894,0.008203808,0.0074241245,0.03881141,0.103391916,0.029871758,-0.0020491825,-0.01513542,0.029451353,0.077126905,-0.024628526,-0.07513592,-0.049799405,-0.013127267,-0.0044920007,-0.059723638,0.012734213,-0.07925871,0.028855138,-0.007968679,5.858441e-33,0.072861716,0.06661518,0.044006325,-0.031017885,-0.015226566,-0.0432379,-0.024572872,-0.096069,0.007905987,-0.07410034,-0.08344746,-0.097794324,-0.022350013,0.14266123,-0.052742798,-0.04522768,0.017848425,-0.03453441,0.14880215,-0.0673392,0.037898775,0.0443561,0.0008425301,-0.0055692918,0.025937995,0.115203105,0.06147205,0.026376253,0.05789672,-0.03557538,-0.0031285058,-0.08447748,-0.045393463,0.08351615,0.033892535,0.057840895,-0.05231735,-0.040492594,0.07466729,0.02198304,0.029762506,0.036871582,-0.03942221,0.0051475787,0.0350024,-0.018964674,-0.049045492,-0.0056429016,-0.0052497745,0.085839376,0.011284692,-0.034871046,-0.029856598,-0.027609518,-0.09290949,-0.027719704,0.037960943,-0.017145732,-0.087163985,0.06334957,-0.02523268,-0.02021969,0.044868007,0.050984967,0.026730932,0.061646737,-0.19698025,-0.024565483,-0.013725884,-0.0008071872,0.024633074,-0.067182854,0.07770178,0.057833817,-0.016729606,-0.0107244365,-0.05196798,0.024270259,0.020089107,0.029257871,-0.05440619,0.0057229325,-0.045315538,0.0046864655,-0.12705342,0.06439773,-0.00797113,-0.116616495,0.07876036,0.03845395,-0.011251433,-0.011664745,-0.012157215,0.013747705,-0.07729546,-6.9121705e-33,0.062351823,-0.054565016,0.12460296,-0.0017199556,-0.07128163,0.03617354,-0.004589301,-0.101916045,0.02257321,-0.03621029,0.03878968,-0.022114614,-0.034301378,-0.04982599,-0.003321293,-0.019555792,-0.015564266,0.08056125,-0.008643738,-0.020304644,0.030839331,0.011514579,0.042143267,0.036225375,0.06814296,0.013604387,-0.025063634,-0.026906753,-0.02277893,0.07856371,-0.060156647,-0.018351853,-0.08572907,-0.054488447,-0.020938257,-0.013026231,-0.07279517,0.017812528,-0.023784906,0.016786246,-0.0065454985,-0.0013892711,0.036200322,0.09001424,0.04657143,0.015014541,-0.0056216926,-0.020320175,0.014967754,-0.07852766,-0.04332761,-0.011370085,-0.020302093,-0.024223004,0.030860558,0.10554389,0.033628732,-0.002149847,0.03881522,-0.07606975,-0.017543498,-0.025843391,-0.085210435,-0.077569775,0.053690214,0.07633077,0.01726637,-0.034745816,0.040494815,-0.04073154,0.025445087,-0.043160554,0.092996806,0.023682123,0.03688927,-0.016945964,-0.07386762,-0.024124818,-0.01581803,-0.040741824,-0.032617964,0.045427434,-0.08553081,-0.0029527012,0.048542645,-0.043099433,0.038324937,0.007553642,-0.01713536,0.0037144122,-0.041957162,0.041155584,0.0024918825,0.018708043,0.05529541,-4.4094165e-08,0.022653366,-0.06972138,-0.06671018,-0.070564665,-0.05328446,0.023416061,-0.032035425,-0.009807914,0.038617313,0.003629134,-0.029767938,0.07056415,-0.024783356,-0.04428544,0.0061991233,0.07509169,-0.025916133,-0.006703513,-0.041916084,-0.06683856,-0.13026948,-0.032138597,-0.083301336,0.12443823,0.01843906,0.02387253,0.0090873735,0.076463826,-0.02867907,0.040571526,0.06200615,0.029705249,-0.08310125,-0.023723707,-0.0057220636,0.049194068,-0.02622104,0.012703338,0.031223351,-0.016390583,-0.03326733,0.0041264943,-0.056330375,0.043916866,-0.019232545,-0.00958396,-0.07718086,0.07241101,-0.06300779,0.045327604,0.011565414,-0.09178717,-0.0023881374,-0.052318633,-0.12235663,0.013910467,0.03732289,0.0017894892,0.030808127,-0.087039486,-0.012201788,-0.0017195237,0.16558455,-0.10673147 +2.4.1.44,"Transfers alpha-D-galactosyl residues to D-glucose in the partially completed core of lipopolysaccharide [cf. EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase), EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)].",384,0.99999994,-0.023987524,-0.09653633,-0.091898374,-0.03243516,0.022077143,-0.00751027,0.025477894,0.0430753,0.021047225,0.022488555,0.0041309083,0.051053394,-0.08243329,-0.016459461,-0.05204104,-0.07515111,-0.042308897,0.014262488,-0.0005389222,0.05961352,0.09148152,0.02139008,-0.010722805,0.037264492,0.08524364,-0.014046289,0.022109183,-0.071276195,-0.038275253,-0.042674277,-0.032745644,-0.0690031,0.05678848,-0.03515519,0.06436186,0.040957395,0.006533779,-0.0075498573,0.025599124,-0.059159208,0.030443603,-0.018698648,0.056997135,0.033051908,-0.015515231,0.008728574,-0.05772118,0.07158966,0.05307841,0.029452842,0.04624091,-0.08033663,-0.09052766,0.0022010752,0.040311847,0.08116636,0.013038913,-0.04202796,-0.017999353,0.039188992,-0.030270603,0.037483487,0.029549612,0.01382398,-0.015800837,-0.108337834,0.12683645,-0.09230118,-0.008400664,-0.030259687,-0.08550738,-0.04432675,-0.026152642,0.0072576334,0.04537533,0.033265665,-0.015338662,-0.0037129708,0.052639086,-0.061073214,0.10902887,0.00035273,0.062517785,0.06683271,-0.04901926,-0.06275281,0.03519773,0.012929052,-0.0005871709,0.0075046094,-0.0017563208,-0.062457126,0.021661084,0.010469912,-0.05511376,0.020199658,0.029668733,0.014842355,0.07333206,-0.05417692,0.007482157,-0.018130798,0.0038656043,-0.06001134,-0.08615438,0.040007927,-0.0026189182,0.03261387,0.000850094,0.006757566,0.026796322,0.008157809,0.05777751,-0.006153452,-0.10838528,0.0038874464,-0.015567782,-0.07453558,-0.06355714,0.00070548547,-0.024631852,-0.022765215,0.13860516,0.0068502147,-0.0300858,0.11117484,0.05211594,5.2527505e-33,0.023568617,-0.016992584,0.020895116,-0.03677741,-0.04266063,-0.007669005,-0.10135487,-0.06253781,-0.012949338,0.006020723,-0.07012525,-0.08170768,-0.0044256942,0.05251932,-0.040982608,0.10745572,0.09458091,-0.020183092,0.0463265,0.040816613,0.007229467,0.096224226,-0.008454188,0.0060876636,0.09721775,0.07827795,-0.09950533,0.040847708,0.04011397,0.007211388,-0.014116781,-0.02264737,-0.03531508,0.041692518,0.06617389,0.037445392,0.015139682,-0.022554418,0.042656533,0.007620093,0.071644634,0.024546435,-0.00426729,-0.05615988,0.008478345,0.045908075,0.01726743,-0.009828978,0.017148333,0.07604955,-0.027696835,-0.04437514,0.02791636,0.06833588,-0.014847954,0.00178663,-0.056842573,-0.061337177,0.048061986,0.059461594,-0.021788137,0.09676882,-0.03027568,-0.029529085,-0.005684234,-0.004629052,-0.08972308,0.00037500975,-0.05988383,0.002729463,-0.01212733,-0.08444496,0.041278698,0.04130106,0.0450775,-0.063617185,-0.02003592,0.066730715,0.013425636,-0.022076828,0.041629765,0.12955566,0.014722546,-0.090866275,-0.0114209205,0.043848366,-0.06434604,-0.041030534,-0.019372422,0.0059485766,-0.10563726,-0.0031737336,-0.004643673,0.028981453,-0.02645934,-8.241836e-33,0.050752126,-0.07339422,0.04885848,-0.06407543,-0.013575816,0.083771124,0.02961501,-0.034725472,0.07665909,-0.007362385,0.035805024,-0.009353996,-0.03555262,-0.05422304,0.05253439,0.0016785725,-0.07932481,0.07505527,-0.087791316,-0.048194584,0.024883144,-0.0029393414,0.010864908,0.04744765,0.064190544,-0.08180773,-0.03353578,0.07225502,0.029832762,0.036592495,-0.0044682724,-0.046777297,-0.048680224,-0.01458765,-0.045373593,-0.019299421,-0.0471152,0.036768913,-0.09899602,0.040903352,-0.008009546,0.099459566,0.07235823,-0.0151434885,0.09590343,0.0320003,-0.079010874,0.0019680627,-0.014652481,-0.043088436,0.012974355,-0.04415984,0.0076389,0.07398514,0.0065364237,0.10384494,0.091805845,0.13250653,0.00047816025,-0.05773613,-0.0505167,-0.049026582,0.009914136,-0.07301402,0.09018855,0.0110953795,0.030096361,-0.0010472272,0.010401467,0.009497968,-0.026686981,-0.027646676,-0.010970702,0.060007866,0.05110811,-0.025921889,-0.13556679,-0.07568181,0.0111848675,-0.038535792,0.069277905,0.02905297,0.009731959,0.01140271,0.028449254,-0.047917448,0.0063810716,0.029972192,-0.032689955,0.018090723,-0.048448164,0.009135679,0.005998164,-0.020097097,0.044505127,-4.7746234e-08,0.060947742,-0.0070953392,-0.021504829,-0.061699145,0.0031278168,0.00019601006,-0.0525141,-0.0012093468,0.07189457,-0.04116218,0.0023656366,0.1320914,-0.00023730777,0.034420177,-0.08214397,0.0049582743,-0.02751519,0.019232258,-0.0071383375,0.04870724,-0.06700893,-0.019940268,-0.09259019,-0.027968887,-0.026323123,-0.10705864,0.08869556,0.019344324,-0.067839175,-0.018478574,0.008199432,0.004112782,-0.03519473,-0.04340754,-0.015320817,-0.018046064,-0.00065641274,-0.038657904,0.03580839,0.08957453,0.002294774,-0.08314429,0.057206646,0.009768897,-0.037213214,-0.00014300829,-0.037678473,0.013010917,-0.048586514,0.08964829,-0.030442137,-0.0407171,-0.138191,-0.088954285,0.008317353,-0.081288,-0.027774945,-0.008320539,0.057383716,-0.03729139,0.0045658597,-0.02322427,0.10286496,-0.016916156 +2.4.1.45,Highly specific.,384,0.99999994,0.019630184,0.020524966,-0.0230152,-0.020047296,0.024092974,0.0406417,0.01810513,0.021626374,-0.087683104,0.025034381,0.049981266,0.07347534,-0.03327476,-0.005415522,0.014728936,-0.03250771,0.14855814,-0.08265671,-0.08764366,0.0051208395,-0.008628811,-0.0033209734,0.062129613,0.01479178,0.017975545,-0.021437574,0.018815499,0.06956224,-0.014540581,-0.033472992,0.00985978,0.035012644,0.04077409,0.016629338,-0.074339546,0.12060398,-0.06889379,-0.0019449351,0.07577824,0.0128357,0.026173191,-0.012304484,0.034301944,-0.008898489,-0.0014370269,-0.022970771,-0.039906796,-0.016499123,-0.04642852,0.008880071,-0.009253621,-0.06546112,0.04591092,0.016099604,0.032182988,-0.065169394,0.03340078,0.011741369,0.071402214,0.032650072,-0.004116478,0.035665374,-0.08813003,0.021229845,0.1509717,0.0002472862,0.006332941,-0.046821017,-0.03000914,-0.02007239,-0.05246243,-0.040659763,0.027719542,0.009111694,0.07351445,-0.05729846,0.04702543,0.0064067594,-0.015810262,-0.056710877,-0.039893474,0.04909444,-0.0063509145,-0.009688946,0.08913302,0.053284056,-0.024151355,-0.029503722,-0.016472684,0.016280608,0.012094162,-0.07541018,0.11545992,-0.04950364,-0.030986318,0.0024644723,0.042414233,-0.10705784,-0.016860437,0.08021278,0.00860762,0.004037125,-0.03389221,0.050065465,-0.008436746,-0.060979486,-0.047801893,0.054549146,-0.06995602,-0.090007484,-0.11495861,0.0024508026,0.024528276,-0.033106238,-0.042515025,0.05307322,0.023206132,0.023664039,-0.012510923,0.039957467,0.026200978,-0.00594072,0.014255891,0.0049632443,-0.08309666,-0.032914195,-0.073286496,-7.926854e-33,0.03455006,-0.031404287,0.014410953,0.16132574,0.006539816,-0.0012397327,-0.0030263695,-0.012293285,0.013739783,0.067143,0.040282838,0.028888106,-0.07640751,-0.00097101065,0.07610626,-7.87875e-05,-0.08878439,0.058396786,-0.019405626,0.0017028035,0.019590734,0.030960713,-0.037802022,-0.04255902,0.029849818,-0.03250836,0.022277417,0.013941744,0.08840643,0.01628505,-0.061007418,-0.003636679,0.009472894,-0.06365878,0.073859066,0.029568287,-0.010664959,-0.051574916,0.020352978,0.023539122,-0.03575704,0.02146051,0.0051506995,0.09166367,0.04022605,0.033915803,-0.020297216,-0.010514895,-0.10557859,0.017497253,-0.10106621,0.021576107,-0.047632392,-0.03696988,-0.010676392,0.026443284,0.019515676,-0.0055166516,0.0785784,0.013454503,0.013761928,0.12697288,-0.09642051,-0.010007327,-0.07321037,0.058839895,-0.03780467,0.040001158,-0.006584064,-0.011659435,-0.05025824,0.035931997,0.19829985,-0.063189216,0.0035671045,-0.011519132,0.030885028,0.09217766,-0.029138278,0.0038970336,-0.06267852,0.06740324,-0.012650777,-0.004273909,-0.010017325,0.010221874,0.06546703,-0.108032525,0.0076424284,-0.03148979,-0.0564091,0.0041891793,-0.04870975,-0.112549126,-0.05134836,6.412181e-33,-0.04432546,0.009828455,0.042573765,0.059921816,0.09757311,-0.042594142,-0.07790132,-0.0018870387,-0.07278392,0.06629037,0.004876445,-0.0432753,0.06928215,0.00031821025,-0.04232126,-0.046658494,0.028597761,0.062944874,0.0083120745,0.017700948,0.023329148,0.013159454,-0.055838257,0.069176435,-0.072506346,0.02255539,0.005077847,0.009823019,-0.06306149,-0.06425466,-0.011728379,-0.09319706,-0.07560494,0.060201306,-0.09963827,0.05960445,-0.045183856,0.02656103,0.018564759,-0.006812521,0.092576146,-0.074929155,0.012449469,0.099080816,-0.071695164,0.0981975,0.011928692,-0.03380255,0.065547206,0.041073408,-0.13639298,-0.011017294,0.063445695,-0.034465868,-0.026307618,0.025647262,-0.015222279,-0.00776089,-0.008022891,-0.024942756,0.00043230207,-0.018748077,-0.030467527,0.03667369,0.020187015,0.04229571,-0.024786936,-0.07082783,0.04597465,-0.032074668,0.009900857,-0.06623191,0.013014218,-0.031125097,-0.13092577,-0.02688007,0.018633615,-0.003443203,0.0005642689,0.039134625,0.032391503,-0.022759462,-0.046837334,0.055766605,0.082204774,0.05723746,-0.06000702,-0.0021942141,0.07709214,-0.074506976,-0.0339119,-0.09277062,-0.03481143,-0.05412553,-0.009034519,-1.597169e-08,-0.03902775,0.070468016,-0.019455398,-0.009087524,0.023859533,-0.011962539,0.030921767,-0.012907053,0.0037944391,0.0391847,0.011287703,0.062478796,0.06302239,-0.01285154,0.07395657,-0.013552048,-0.017470121,0.05409657,-0.088913724,0.035792217,-0.027000815,0.04636564,0.08569034,-0.047154877,0.051179532,-0.010523361,0.058381774,0.054288268,0.009419741,0.027628561,-0.021505713,0.0030071926,-0.016405545,-0.036033046,0.047253825,0.07232611,-0.02523354,-0.029568175,0.07488461,-0.06413469,-0.02512882,-0.019198509,-0.014097056,0.09558656,0.067996286,0.012986802,0.0065120235,-0.0055387574,0.028456492,0.052861493,-0.047109302,0.06943612,0.010978891,0.05891871,0.051110785,0.030609403,0.0015038289,-0.06334439,0.03703199,-0.043403536,0.13312547,0.0719006,0.025956877,0.031312965 +2.4.1.46,"This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4].",384,0.99999994,-0.055852193,-0.10163991,-0.02191764,-0.0030176977,-0.01166982,0.019292021,-0.034616634,-0.03155752,0.05095637,-0.041060366,0.08926889,-0.03902113,-0.037511133,-0.042185925,0.04520012,0.010460249,-0.06835304,0.09258868,-0.06269428,-0.05837749,0.14311317,0.056372978,0.013525543,0.03920584,0.06255392,-0.07735431,0.01221852,-0.018611299,-0.00025195777,-0.09136524,0.045749623,0.00079765485,0.10775745,-0.02671611,0.054136943,0.007192508,0.022601498,-0.023197917,-0.022856837,0.002171179,0.06364917,-0.025001144,0.00902634,-0.0048933146,-0.08548379,-0.020800376,-0.05860877,0.0031250296,0.037962515,-0.040436834,0.011342023,-0.067209065,-0.07698451,-0.008175649,0.055653587,0.01118246,-0.043637473,0.0018949716,0.011185153,-0.015338051,0.06564366,0.054776363,0.0012087487,-0.0021742627,-0.027183764,-0.028706307,0.022560125,-0.075239725,0.07463949,-0.06165776,-0.031469945,-0.097014114,-0.03978828,0.014888233,-0.09114809,0.060000874,-0.009520337,-0.03185086,0.012897075,-0.049912333,0.055580817,0.0076178946,0.02203843,0.06598289,-0.021068418,-0.03058672,0.045443863,0.030834617,0.0055727535,0.0054730913,0.050092425,-0.019444877,0.02921732,0.025448428,-0.011951466,0.0798693,0.009899508,-0.03619453,0.064940766,-0.015985379,0.008677328,-0.020136276,-0.0061718784,-0.011307443,-0.018528836,0.01413871,-0.056526516,0.012801973,0.0024897787,-0.013998906,0.059674103,-0.008576736,0.017065015,0.043554094,-0.03921391,0.036823682,-0.044564262,-0.030317765,-0.045172375,-0.024766818,0.025741749,-0.061469335,0.055753004,0.0065535135,-0.058876757,0.060135953,-0.0787048,4.7227837e-33,0.065142125,0.081926085,-0.034740344,-0.0030295579,-0.032974273,0.0066201617,-0.06839787,0.07043553,-0.053475402,-0.039948184,-0.09453152,-0.045419734,-0.042443357,0.08642896,-0.08046621,-0.0017942231,-0.011914714,0.05884178,0.079712965,-0.018416543,-0.065573245,0.07524922,-0.047444314,-0.04751301,-0.010286423,0.05700171,0.008335998,-0.056747388,0.078356415,-0.008601936,0.013266686,-0.0961807,-0.04784236,0.054244325,0.029057872,0.042312235,-0.014769499,-0.048930254,-0.03501316,-0.012561905,-0.040977973,0.032727607,-0.053407706,-0.018726757,0.06527682,0.026260504,-0.12883109,0.07075983,0.0381871,0.069305554,0.004831374,0.0615822,0.09180555,0.01913248,0.0052753706,0.014743947,-0.0067433747,0.04401013,0.019259589,0.008802825,-0.010728297,0.12487864,-0.01389816,0.027450329,0.019005798,0.10340996,-0.097097725,-0.080197014,-0.016664222,0.057052977,0.010926564,-0.039542567,0.011028833,0.07904112,0.017830526,-0.04703744,0.010754883,0.014206385,-0.027609758,0.043050874,-0.057286788,0.08130628,-0.011161683,-0.03843014,-0.05356568,0.0004719254,-0.07539693,-0.016234284,0.0059010834,0.06630233,-0.031639192,0.015486011,-0.005509538,0.104958795,0.063006535,-4.9028995e-33,0.046191584,-0.0030203238,0.073093146,-0.08587966,-0.027559767,0.026436055,0.036143024,-0.033626378,0.076171696,0.04288479,0.053626236,-0.03107324,0.0024483707,-0.10961079,-0.041282643,-0.06286061,0.01392031,0.07660648,-0.08594196,0.043816376,-0.037001178,0.090874545,-0.018981097,0.103177615,0.049045574,0.00930821,0.0029662373,0.050690096,-0.037626855,0.045197576,0.08674155,0.03788128,-0.04321426,-0.039681654,-0.07627179,0.021045944,-0.073630475,0.05867095,-0.029046725,0.04146129,-0.114567526,0.0710225,0.07377814,0.06648557,0.072946995,0.003750235,0.018668177,0.015001853,0.0096798455,-0.043052666,-0.055797122,0.0035853866,-0.0069368747,0.06442108,0.059021182,0.07294739,0.04070378,0.0645373,-0.019742267,-0.07414283,-0.03313091,-0.076782115,0.07375915,-0.07395932,0.054790135,0.015068652,0.013360275,-0.013100704,-0.01429755,0.060083117,0.07217701,0.010167688,-0.014645562,0.02142216,0.0187541,0.004985995,-0.059305336,-0.074157596,-0.05824202,-0.07467302,0.06723351,0.06549965,-0.01559569,-0.02894187,-0.06864436,-0.054611586,0.031197576,0.12508644,-0.0018276518,0.053117026,-0.045032296,-0.015608187,-0.057448372,0.027254796,0.06278387,-4.1703245e-08,0.010089162,-0.037241835,0.016926643,-0.10895709,-0.01842021,-0.0043141707,-0.04085231,0.037189424,0.10715425,-0.08440254,-0.04021228,0.09018865,-0.028500753,0.014997183,0.040876836,-0.011740086,-0.001863013,0.053974606,-0.016977284,-5.2227228e-05,0.009590331,-0.034961756,-0.09919331,0.007119278,-0.0394951,-0.10704289,0.025034238,0.034364186,-0.00076296984,0.046494614,0.06287884,0.014463189,-0.051021393,0.022221575,-0.0028262872,0.041004304,-0.0214988,-0.002330625,-0.0021393767,0.03620284,-0.026751107,-0.05920707,0.020671455,0.026666421,-0.02723847,-0.059509706,-0.03401819,-0.027992826,-0.07428918,0.10911109,0.008827512,-0.06747895,-0.012338984,-0.10286027,-0.08452133,-0.0152388215,0.0033683316,-0.02158141,-0.045708045,-0.003056193,-0.037757277,-0.06315965,0.14598522,-0.024356911 +2.4.1.47,"This membrane-bound, endoplasmic reticulum-located enzyme catalyses the last step in the synthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. It has a strong preference for ceramides that contain hydroxylated fatty acids.",384,1.0,0.0069255168,-0.12328028,-0.110030025,0.00042422622,0.028393907,0.027583962,-0.01595948,0.048971143,0.034815922,-0.02488054,0.026645638,-0.01783024,-0.09134344,-0.0021912684,-0.037069242,-0.017068943,-0.0070773303,-0.009441465,0.022839714,0.023129147,0.051185686,-0.030405339,0.0034742749,-0.016389899,0.04224253,0.017448641,0.06144664,-0.053501423,-0.0028866732,-0.048332244,0.06914358,-0.045034375,0.05195761,-0.047072783,0.009491167,0.07466525,-0.04776864,-0.06126759,0.033082493,-0.061052416,0.007905097,-0.0149891535,0.0066479854,-0.0155462595,0.0002133871,-0.020056222,-0.0065038344,0.026638009,0.020585354,-0.014383639,-0.016762106,-0.08453704,-0.095497206,-0.0015455732,-0.023380492,0.07087112,-0.07810603,-0.015637618,0.0103099365,0.07513685,0.031403255,0.009242766,0.01891671,0.031446848,-0.014745472,-0.05975576,-0.026420958,-0.061045676,-0.022925979,0.014428335,0.0013771901,-0.08051601,-0.015144932,-0.00866332,0.04305829,0.08097735,-0.013264127,-0.027762474,0.07772376,-0.045786265,0.075747065,-0.0034622096,-0.010803538,0.101023175,0.0998647,-0.00014888131,0.09855441,0.045647554,0.010643043,0.028968222,0.0972023,-0.05212204,-0.035725895,0.018601047,-0.06192724,0.050877936,0.036107305,0.01070438,-0.0038058597,-0.06948714,0.03304759,-0.02099357,0.07181372,-0.025963731,-0.0007710837,0.09947438,0.0044834283,0.077527,-0.03290722,-0.016401863,-0.032404795,-0.022012487,-0.012909908,-0.02985227,-0.0021407849,0.05496045,0.03874896,-0.007466756,-0.025778128,-0.016315963,-0.004634506,0.0096502425,-0.021796808,0.0286994,-0.030896151,0.036842305,-0.05345485,2.3631332e-33,0.006216753,0.037991803,-0.01854501,-0.01818663,-0.03958714,-0.036163412,-0.065474786,0.0030547515,0.0035398765,0.014018478,-0.07847868,-0.023177704,-0.028501775,0.06397016,-0.007640159,-0.0041354164,0.019261451,-0.038569015,0.10234308,-0.03816274,-0.04494248,0.0029779128,-0.009390271,-0.0861623,0.04403855,-0.008324964,-0.02533018,0.03869023,0.07781356,0.008120714,-0.01232163,-0.06109008,-0.071696654,0.053546023,0.036368094,0.10906616,-0.0047851983,-0.05052081,0.03312254,0.009465912,-0.013846708,-0.0054955967,-0.0265173,-0.03234571,0.014961211,-0.06620464,-0.050504237,0.056591954,0.054794848,-0.11253773,0.03366332,-0.024475163,0.024460884,0.05794178,-0.0003079902,0.014572273,-0.028659416,0.04222253,0.0018558541,0.062204733,0.007567577,0.06084774,-0.037232514,0.07375109,0.05970915,0.02381357,-0.024127338,-0.033426214,-0.082316354,-0.041655608,-0.013489984,-0.044681918,0.14519636,0.013628504,-0.025675975,0.0151337115,0.025139928,-0.006554212,-0.026726535,-0.038468726,0.072464816,-0.0048322883,-0.0192632,0.049296107,0.025191663,0.033927444,-0.06767485,-0.036504906,-0.014805984,0.008917639,-0.033602018,-0.050040662,-0.033105496,0.08246511,-0.103316315,-3.1988695e-33,0.020622108,-0.10892772,0.07414097,-0.11852006,-0.036067814,0.07263143,0.044272147,-0.0700664,0.06478099,0.015934804,-0.027550258,-0.022515519,0.03811876,-0.12950383,-0.007772106,0.030903935,-0.027295671,0.044882942,-0.0026116115,-0.12527847,0.00029249143,0.100770354,0.0059965253,0.0885346,-0.00838513,0.008954439,-0.010858862,0.026816074,0.0051147724,0.07115478,-0.010855527,-0.091426164,-0.056001697,-0.06256185,0.01022192,0.03496219,-0.051377695,0.010786491,0.009839404,0.048844375,-0.05130508,0.026803449,0.05478292,0.00069252716,0.12688497,0.04349108,-0.047101513,0.07289113,0.008347084,-0.04016805,0.01104992,-0.029582582,-0.014915886,0.062948845,0.011732929,0.056097206,0.028660033,0.006897231,0.08225117,-0.12741621,-0.08042905,-0.008948407,0.02527515,-0.10453841,0.08814973,0.042541247,-0.06554306,0.00504673,-0.018061543,-0.005844054,0.056297913,0.013785646,-0.106935516,0.06590124,0.012375504,0.06274074,-0.058406603,-0.11228662,0.021427251,-0.004341725,0.07056581,0.074481145,0.03659468,-0.035690013,0.05170046,-0.0022628119,-0.015162925,0.06610851,0.05677807,-0.030298326,0.013737732,-0.003762552,-0.04937736,0.022105435,0.059303302,-3.4873487e-08,0.06786042,0.011926039,0.004113592,-0.11792193,-0.034915235,-0.02886735,0.056998216,0.011601859,0.044612452,-0.08089303,-0.068679556,0.087886535,0.011984764,0.018060949,-0.046878275,0.10156637,-0.0012398513,-0.013145292,0.00961124,-0.10431719,0.048342638,-0.056855835,-0.023537222,0.015468814,-0.018343173,-0.09593406,-0.0022591793,0.037573036,-0.03777484,0.06623719,0.04655363,-0.0025020943,0.02241697,-0.0124745825,0.041307513,0.07306775,-0.04611136,-0.026890753,-0.014696973,0.053708486,0.016889112,-0.06958876,0.050455958,0.004556945,-0.07219103,0.014629565,-0.001745767,0.09282792,0.05128966,0.10854989,-0.015383053,-0.04305405,-0.07654751,-0.052046806,-0.090059586,-0.099526085,-0.048121117,0.014460086,0.032013085,-0.10025301,-0.019656383,0.08217823,0.14847207,0.0066425046 +2.4.1.48,"The acceptor is a heteroglycan primer containing mannose, galactose and xylose. 1,2- and 1,3-mannosyl bonds are formed.",384,1.0,-0.008760761,-0.015539386,-0.056262452,-0.032935124,0.013360603,-0.06834013,0.08618841,-0.019236049,0.008508747,0.05209684,0.09757799,0.01191829,-0.05986989,0.007578238,-0.023321537,0.04438383,-0.0737237,-0.023784144,-0.009408036,0.076040484,0.050786283,0.027867284,0.021855298,0.031391952,-0.0035638937,-0.034419004,0.007945072,-0.09607337,-0.009097887,-0.1286206,0.0057378076,-0.08314487,0.060740776,0.028131545,0.03703199,-0.022932393,0.011284991,0.01385848,0.019893067,-0.027329817,0.017808245,-0.12708235,0.021546915,0.012239025,-0.07159282,-0.034050837,-0.09720483,0.054359592,0.026145888,-0.023725849,0.027858816,-0.016872633,-0.06945289,0.046536494,-0.0037081975,0.03438026,-0.07341948,-0.063352324,-0.031676196,-0.025064707,0.007902656,0.033459324,-0.014146134,-0.002364344,0.0047412827,-0.05029915,0.048888784,-0.06984826,0.0058383415,0.011239377,0.020459322,-0.015141164,-0.025167616,-0.08916783,0.09055845,0.023086794,0.0092018815,0.020590007,0.045425348,0.0065329536,-0.004390453,-0.018752491,0.038511176,0.07400356,-0.003323886,-0.0045368117,-0.03010147,0.0482106,-0.0080967955,0.014918498,0.015751477,-0.016079081,0.03953217,-0.033242386,0.026721688,-0.0007167194,0.06682753,-0.0328091,0.109235145,0.036160316,0.042252265,-0.01685837,2.651893e-05,-0.07856535,-0.08960963,0.045501616,-0.036088087,0.023364319,0.039968707,0.00029170892,-0.021858813,-0.07633283,0.060457483,0.010671631,-0.12850192,0.06325694,0.0038212296,-0.0626657,0.095976725,-0.113618664,0.00876307,0.05854498,-0.012803794,0.007283551,-0.03916559,-0.0073310453,-0.06543105,-8.038801e-34,-0.017520487,0.07766188,0.038570706,-0.028104713,-0.03244021,0.048159394,-0.040551607,-0.02884735,-0.10511957,-0.023162132,-0.12951861,-0.07004749,0.0022351814,0.09842275,-0.029459478,-0.0018397013,-0.023526495,0.08372627,0.047158252,-0.014305528,-0.05377971,0.11560726,-0.055046286,0.0095211165,0.035787508,0.073736385,-0.057109315,0.0015891877,0.046969038,-0.02929243,0.12269927,-0.006009925,0.0010110153,0.037030373,0.01656134,0.06483237,0.02238496,0.0106248995,0.0029883354,-0.06450153,0.008403167,0.025692426,-0.057833128,0.022309108,0.0345977,-0.059276372,0.00058195414,-0.016720807,-0.00026991492,0.0333008,-0.008955764,-0.0092039425,-0.076008536,0.037747603,-0.009496384,0.041221768,-0.018327134,0.04052965,0.018507587,-0.0057335733,0.021837274,0.059871893,-0.02297854,-0.021958636,-0.02273082,0.037577357,-0.023293614,-0.00193114,-0.028291808,0.092597835,-0.10302259,-0.016451072,0.061747063,0.01035923,0.05925127,-0.0047028163,-0.06687067,-0.01219758,-0.04576429,0.05363635,-0.017386548,-0.008977713,-0.03177009,0.044668134,-0.17006665,0.013808441,-0.0020639608,-0.07590129,0.08066933,0.098270684,0.003591717,-0.038480412,-0.094434686,0.010056315,0.009854432,-1.8654074e-33,0.08880975,-0.08985804,0.09589955,0.04383981,0.01227722,0.03030857,0.042573262,-0.07432471,0.12457943,-0.0211948,0.08143391,0.06482284,0.050610606,-0.054128837,0.025574194,0.0041142316,-0.0049605495,0.10929615,-0.05370695,0.053662915,-0.00786533,0.07199373,-0.035704263,0.012798042,0.008413776,0.009618891,-0.010370817,0.03731278,0.025593484,0.031210283,0.0011380074,-0.031489838,0.005584281,-0.07361357,-0.011922776,-0.017442096,-0.05258666,0.030859439,-0.041389618,0.034834296,-0.051458634,-0.025172057,0.044725742,0.06902554,0.06463245,0.049784515,-0.004284434,0.06271938,-0.020120148,0.00059230515,-0.0130921565,0.022712575,-0.0007920415,-0.007479641,0.12264429,0.081351236,-0.01660656,-0.02558002,0.008484341,0.012823713,-0.019814467,-0.014187053,0.05729517,-0.017560408,0.04203621,-0.052123856,-0.06039907,-0.015585338,0.020653792,0.019457517,0.062384944,0.020803152,0.020276954,0.046224825,0.103748344,0.004500166,-0.11458561,-0.082908995,-0.028759332,-0.011414893,-0.010439732,0.01819832,0.06725209,-0.02770013,0.020338397,-0.0155942,0.065031536,0.056667004,-0.041186325,0.00016815102,-0.030893093,0.042300846,0.0054783607,0.035341885,0.049330045,-3.05833e-08,0.00689405,-0.04746221,-0.04532308,-0.15494557,-0.074134044,0.024148487,0.047871266,0.026856596,-0.06424395,-0.0244963,0.037182644,0.094896175,-0.0041050278,-0.07701076,0.052952457,-0.060825232,0.024531825,-0.0025795586,-0.06581316,-0.06005423,-0.10296544,0.041383307,-0.038026337,-0.12147256,-0.048025746,0.008831365,0.06349991,0.0068275183,-0.051247697,0.010802851,0.06888776,0.06498543,0.01399065,-0.056005973,0.009708904,0.07937559,-0.044435494,-0.01218763,0.065413736,0.03025469,0.05268136,-0.0405102,-0.07305686,-0.028251665,-0.06594673,0.014481086,-0.008908472,-0.011977225,-0.09829825,0.016072517,-0.022492282,0.000873616,-0.06737345,-0.035650544,-0.050758522,-0.046265494,-0.030480303,-0.012649837,0.016053772,-0.079967536,0.049752835,-0.04957061,0.1471678,-0.005997839 +2.4.1.50,Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.66 procollagen glucosyltransferase).,384,1.0,-0.04141531,-0.03841252,-0.12306929,0.014615757,-0.034368493,0.044464402,0.004802682,0.12129132,0.041569367,-0.043279275,0.052231863,-0.09570124,-0.06913316,-0.06725435,-0.082952686,-0.0855539,0.011952819,-0.031217186,-0.027700251,-0.028040707,0.017976332,0.00584156,-0.0072194175,0.02851163,0.05815955,-0.09507159,-0.012500793,-0.05092704,-0.027135713,-0.044600725,-0.048301246,-0.026711654,0.017666023,-0.071470335,0.0747013,0.012991236,-0.0111364955,-0.030636728,0.013104081,-0.021651955,0.01118566,-0.048564795,0.004492169,0.0028360742,-0.02994488,0.051023606,0.018047119,0.103320085,0.018664898,-0.0128377285,0.014111267,-0.034698803,-0.04506284,0.015786925,0.03286606,0.037308857,-0.08684929,-0.02362945,-0.022058945,0.034243427,-0.03895532,0.0547695,-0.04211398,-0.054926008,0.02381598,-0.081963465,0.06192661,0.013118337,-0.035363097,0.023634875,-0.05279125,-0.03184536,0.029432558,0.02232179,0.0069364966,0.059137795,-0.037951954,-0.014130399,0.01861369,-0.015929298,0.065546855,0.021110501,0.045913436,0.052512206,-0.06543312,-0.025761774,-0.025683705,0.048420396,-0.08408829,-0.01891397,-0.023906298,-0.0034966513,0.056801092,-0.005647943,0.005832226,0.057566337,0.06377989,0.0092471745,0.11630098,-0.017565606,-0.014267869,0.03244834,0.09779039,-0.015388542,-0.060479365,0.06466646,0.0033131232,0.19244315,0.093954496,-0.086954415,0.026826104,-0.010304135,-0.027473936,-0.043598495,-0.05099066,0.028757757,0.016785847,-0.10241684,-0.011671763,0.023355942,0.006796209,0.007957689,0.028546857,0.036801,-0.10155366,0.06354281,0.054655645,3.6874877e-34,0.06781125,0.0075295926,0.04869235,0.017326942,-0.046563976,-0.0016991812,-0.081450954,-0.009252017,0.0019626461,0.00919082,-0.10634471,-0.1444778,0.026773715,0.09492953,-0.046643864,0.017514076,-0.0010877737,-0.08854037,0.0547406,0.019343369,-0.031066166,0.09047425,-0.026891455,-0.051088788,0.020879366,0.061041966,-0.0841434,0.02509577,-0.033400744,-0.026004434,0.008834349,0.0070157666,-0.0016782458,0.05739125,0.024146315,-0.04830144,0.05103481,-0.069422215,0.019767873,0.03559005,0.0894764,0.018132847,0.010559897,-0.043781895,0.0687882,-0.03255293,-0.03649572,0.029072631,-0.024479976,0.122645535,0.08697878,0.03250558,0.028495437,0.044124722,-0.049422715,0.04960773,-0.041517753,0.05205684,0.024060046,0.061285697,-0.018139618,0.09306838,0.0030868691,-0.04661241,-0.030311568,0.083220944,-0.092999704,-0.078025796,-0.0334732,-0.020561144,-0.08030755,-0.08729828,0.038009465,0.055296108,0.08984789,-0.030263912,-0.009002629,0.074403815,-0.06951742,-0.0025106485,0.03375369,0.15239999,-0.0029397325,0.04409508,-0.03970713,-0.01851916,-0.044789545,-0.087253965,-0.006098309,0.039532177,-0.02743027,-0.020911174,-0.06144645,0.063726105,0.013988039,-1.999665e-33,0.103644036,-0.06965818,-0.06898251,-0.038506906,-0.025376575,-0.00610771,0.02686927,-0.0955118,0.0023399368,0.03999576,0.09923885,0.03660904,-0.006690402,-0.059707917,-0.026671246,-0.0008834315,-0.011846,0.055591192,-0.013404863,0.0001602196,0.008230766,0.048825156,0.079713486,-0.047411814,0.09633487,-0.05255437,-0.010469235,0.01863241,0.0236026,0.020840602,0.021637669,-0.07620873,-0.028167931,-0.0060669184,-0.04085757,-0.04669534,-0.03645545,0.027531924,-0.025332417,0.009198308,-0.021025352,0.024175676,0.018397538,0.011010052,0.106568515,0.09194056,-0.008304243,-0.0901189,-0.043509044,-0.005926148,0.059196383,-0.002417803,-0.00056319067,0.03241055,0.051152866,0.070016965,0.13930489,0.044625696,0.08614292,0.0003872904,-0.02790819,-0.061371222,0.05019994,-0.03994899,0.040940728,0.007447285,-0.043995723,0.030742858,0.09206609,0.008556526,0.07603865,-0.061784614,0.01775677,0.05181562,-0.018424312,-0.002298092,-0.04797628,-0.052937392,-0.02507031,-0.050361875,-0.058702793,-0.067376606,0.025732877,-0.05844715,0.07141109,0.00021770014,0.004524822,0.06310637,-0.041517273,0.04565933,-0.04141787,-0.0472952,-0.014841498,0.011657584,0.008362508,-2.9114274e-08,0.08247282,-0.018800724,-0.024853008,-0.04153136,-0.03139426,0.054043297,-0.0012221265,-0.0035744687,-0.010533472,0.0150434105,-0.013912874,0.033171754,-0.012605569,-0.016307835,-0.05246179,0.013146371,0.030410323,0.02786523,-0.02642468,-0.022448592,-0.07217298,0.008371557,-0.063147046,0.010354693,0.030403903,-0.16356269,0.041934945,0.089690745,0.01502491,-0.0018825077,0.021636477,0.066628225,-0.024216097,-0.041593146,0.033385932,0.051900152,-0.0046204682,0.04097137,-0.0027123096,0.00958885,-0.019288292,-0.01919766,-0.027120419,-0.024695337,0.06558972,0.039850008,0.014971108,0.07924034,-0.013320495,0.02311871,0.033263378,-0.047278192,-0.07404805,-0.0038957195,-0.012012596,-0.03349383,-0.0022971353,-0.056740988,0.0026207746,-0.06498861,-0.044367373,0.06179293,0.057536613,-0.07819572 +2.4.1.52,"Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme, isolated from Bacillus subtilis 168, adds an alpha-D-glucose to the free OH groups of the glycerol units. The enzyme has a strong preference for UDP-alpha-glucose as the sugar donor. It has no activity with poly(ribitol phosphate). ",384,1.0,-0.01990368,-0.069573954,-0.07708155,-0.064434625,-0.030495046,0.027948536,-0.043189224,0.034333646,0.04239529,-0.009731321,0.00830673,0.023017138,-0.023754127,0.047631375,-0.040137958,-0.079353236,0.03562363,-0.009516073,0.0051900446,-0.025322907,0.07939853,0.043406513,-0.0034293346,-0.014386938,0.0263212,0.0009873677,0.05948934,-0.051066454,-0.0031002965,-0.0056385226,-0.034314405,-0.07144823,0.07609978,-0.086254634,0.08019061,0.13241461,-0.04694919,0.029385854,0.037417553,0.023600863,0.028128475,-0.03903875,0.03147665,0.0005935866,0.009091592,-0.006918342,-0.032750044,0.0102276625,0.005688527,-0.013197929,-0.055306666,0.0033508632,-0.042053092,-0.047158305,0.037412114,0.022156974,0.0054602623,0.046895456,0.0030796062,-0.031718466,0.0021384566,-0.027766647,0.07652432,0.017174218,-0.03872045,-0.030054647,0.06635789,-0.020675609,-0.026859287,0.007516971,-0.0012478561,0.04923623,0.0434772,0.001132918,-0.011777031,0.0130920205,-0.05322576,-0.04749252,0.032978695,-0.0044575334,0.047052223,-0.07622989,-0.050189007,0.1120894,-0.042239137,-0.024156528,0.017041989,-0.0402698,0.013367759,0.030871827,0.01833744,0.01457261,0.023452265,-0.06933195,-0.065423295,-0.04418215,-0.030898416,-0.053972926,0.009975499,-0.085364774,-0.059124373,0.054025084,0.0032878767,-0.07168227,-0.076692164,0.034617744,-0.04752332,0.03166307,0.050285276,0.09025786,0.003041907,0.05572892,0.043693893,-0.016962891,-0.04831446,0.023897279,0.016086394,-0.07591383,-0.06290226,-0.028926693,0.0031079934,-0.09389257,0.075466,0.023674786,-0.03108724,0.053579666,0.0042940727,8.327897e-34,0.12188377,0.017958673,-0.037771802,-0.05432399,0.01943747,-0.010149353,-0.05767968,-0.05501446,-0.09113508,-0.011077344,-0.079584986,-0.062453024,-0.0045165587,0.07198014,0.032542355,0.06758792,0.019915985,-0.0039714104,0.07817304,0.024750302,0.018555146,0.10743803,0.04240798,0.022769473,0.024080772,0.044985868,-0.009419574,-0.022411007,-0.012794857,6.6052686e-05,0.075541034,-0.0720771,-0.10107803,0.050769955,0.124703646,0.018468343,-0.12294294,0.007990341,0.07591519,0.020312587,-0.007201102,0.04348701,0.08703347,-0.056555092,0.0709988,0.06144421,-0.00032858283,0.02354904,0.024954317,0.046373475,0.04553933,0.04618476,0.009264775,0.020582383,-0.054413214,-0.019878114,-0.013986729,0.060219567,-0.04063981,0.0551498,0.017832167,0.07944258,-0.013502379,0.010404398,-0.06463565,-0.029677749,-0.06107882,-0.037280083,0.050250564,-0.042081323,0.041600298,-0.0051279087,0.07901122,0.014180032,-0.07581766,-0.007507934,0.007603247,0.003180089,-0.012504249,-0.054433383,-0.0028408612,-0.00543998,-0.022522679,-0.063541934,-0.040793546,0.05801955,-0.0059388876,-0.0478992,-0.012099681,0.010944004,0.025908211,-0.09389526,-0.056219265,0.06575561,-0.0493462,-2.6031304e-33,0.11491089,-0.12564504,0.13837281,-0.07652815,-0.052151993,-0.0059485263,0.014704929,-0.0104636,0.04907188,-0.018443268,0.047766346,0.05231372,0.0518274,0.020194357,0.0021142503,0.03803406,0.008037054,0.072236665,-0.086460724,-0.115955345,0.0010262569,0.040395796,-0.010269115,0.03551093,0.04498919,0.06083876,-0.011663056,0.042075586,-0.019626461,0.011583719,0.013784651,0.06041848,-0.08347209,-0.04141644,-0.04944179,0.011853126,-0.021642057,-0.007423924,0.0419117,-0.008357986,0.01351234,0.10639757,0.077649444,-0.036187492,0.05119164,0.052380227,0.006295669,-0.07076296,-0.050459277,-0.03617679,-0.01181205,0.012100333,0.031122886,0.016786974,0.065810874,0.05427025,-0.008259853,0.09679842,-0.051849946,-0.07155445,0.0010276162,-0.09091411,0.060687225,-0.016902154,-0.0023148684,0.13215546,0.07476517,-0.041468114,0.054917164,-0.0061889365,0.0029805633,0.01769855,-0.0071980474,0.086142726,0.010251728,-0.00927974,-0.12176774,-0.0377756,-0.019245725,-0.023085777,-0.008381335,0.022792166,-0.050658397,-0.03599893,0.06345362,-0.10799964,0.039713368,0.08970542,-0.005206861,0.024141122,-0.057867303,0.021342363,-0.0124012,-0.0155346375,0.12802964,-3.8735106e-08,0.05287764,-0.04420804,-0.017707726,-0.05572288,-0.031140193,-0.026117524,-0.00063468376,0.0052492293,0.048685685,-0.06942063,-0.060917594,0.06776719,-0.050545294,-0.016584147,0.00214856,0.05871143,-0.11011613,-0.08214636,-0.0425613,-0.08133153,-0.04702078,0.013700617,-0.1394656,0.09129416,-0.07643187,-0.04766246,-0.017248992,-0.07004351,-0.014278411,0.005276198,-0.0072733015,0.031518646,0.0030453855,-0.050532423,0.0013389621,0.02408801,0.0018063257,0.009121169,0.013420544,0.077645145,0.0034500677,-0.07105154,-0.05471956,0.028782923,0.0011431662,0.02779573,-0.051753387,0.044425618,-0.06652299,0.04455807,0.040964264,0.011176721,-0.047199488,-0.04971152,-0.08960534,0.0036907953,-0.057166997,-0.048843935,0.018087536,0.031662986,-0.012979923,-0.025208488,0.131535,-0.09699594 +2.4.1.53,Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Bacillus subtilis W23. This enzyme adds a beta-D-glucose to the hydroxyl group at the 2 position of the ribitol phosphate units.,384,0.99999994,-0.034975097,-0.038934752,-0.05314188,-0.07003771,-0.03539927,0.040421985,-0.08690078,0.016718758,0.07317401,0.0049856333,-0.0077500446,-0.03705311,0.053139452,0.012945979,-0.04357607,-0.039223235,-0.055794213,0.014874904,0.0033238083,-0.05469155,0.09437535,0.0865663,-0.010124756,-0.011502555,0.02539273,-0.0032684405,0.07632103,-0.041793246,-0.028885553,0.014716359,-0.037310347,-0.031643476,0.079368055,-0.0743051,0.03486439,0.10236654,-0.016896714,0.010196829,0.13145976,0.016667932,-0.007250409,-0.015450466,0.010934296,0.006526939,0.023006009,-0.010755569,-0.010783766,0.053960413,0.027570859,-0.026708147,-0.09985284,0.026912529,-0.0570917,-0.007771316,0.050333258,0.014078808,0.03975035,-0.00546303,0.045152877,-0.05479939,0.012187199,-0.065449856,0.034619052,0.001975087,0.012702404,-0.059445065,0.01695616,-0.005355388,-0.035108592,-0.031944923,-0.020158662,0.043082457,0.0033354154,0.001554364,0.023868786,0.014532698,-0.048787866,-0.022717973,-0.023600597,-0.029978339,0.039688386,-0.04677315,-0.04546609,0.109778486,0.012884371,-0.06323992,0.045310523,-0.03280477,0.026461959,0.061975658,0.0007621512,-0.009829522,0.005946541,-0.045584936,-0.022763228,-0.041918624,-0.033132106,-0.04840367,0.027633505,-0.07038656,-0.044949558,0.02378154,0.042806618,-0.024885505,-0.056634568,-0.015695306,-0.018166283,0.14777002,0.014455674,0.07065398,0.05862201,0.03125108,-0.007584776,-0.028515445,-0.02394407,0.046544533,0.056977607,-0.102041416,-0.062638424,-0.049839538,0.011299141,-0.034970146,0.031791925,0.0028794655,-0.04175921,0.017131057,-0.038483083,1.919348e-33,0.12140313,-0.036473155,-0.016472796,0.012283438,-6.785955e-05,0.032412224,-0.0921162,-0.061678313,-0.01518615,-0.0062030395,-0.13644797,-0.12309463,0.025868842,0.01711454,0.015910044,0.030736225,-0.03432665,-0.003988614,0.04259905,0.054295857,-0.0078599565,0.119029194,0.009001386,0.027110185,0.0033182623,0.033575922,0.016699206,-0.058712024,-0.025533311,0.0062216376,0.058799613,-0.03416312,-0.06949818,0.010274505,0.076148234,0.025544737,-0.07502543,0.013596406,0.059530303,0.0023872484,0.033910763,0.057594426,0.037674118,-0.066197455,0.07455688,0.037700824,0.06679084,0.0509487,0.0069585866,0.103430584,0.034038637,0.052775193,0.044233195,-0.013702754,-0.026014972,0.006836866,-0.0068511735,0.016769432,-0.03149654,0.0719794,0.013191746,0.027715148,0.009456761,0.10096424,-0.06728883,-0.049048442,-0.0452217,-0.03882722,0.01775355,-0.018438572,-0.022186836,-0.0116037,0.107036665,-0.017358245,-0.086984515,0.01768048,-0.019414764,-0.036943108,-0.024673562,-0.061149124,0.026897319,-0.0009843445,-0.038477134,-0.07208169,-0.021354124,0.074679054,0.00874143,-0.08889599,-0.0091284895,0.023580188,0.05541202,-0.082444154,-0.0814459,0.07066673,-0.00080545095,-3.577117e-33,0.117998265,-0.12733479,0.12498517,-0.12872039,-0.074722506,-0.031755798,-0.003861452,-0.049707644,-0.021606924,-0.013889777,0.0350803,0.05447786,0.0015686925,0.0025628535,-0.009877464,0.013723009,0.053098902,0.053767536,-0.03966787,-0.044793576,0.02956366,0.065706655,0.008463861,-0.02095388,0.009678417,0.08395059,0.019308789,0.07319483,0.046932153,-0.009512144,-0.03876335,0.012130426,-0.02678967,-0.014214085,-0.041633464,0.047408875,-0.026357591,0.010893976,0.07138639,0.010573525,-0.007489662,0.08414912,0.019025123,-0.023346823,0.048929904,0.038538404,0.04232944,-0.07088662,-0.06608115,-0.09577014,-0.01264988,-0.021514043,0.057471856,-0.01128982,0.009569507,0.017151963,-0.04881454,0.105967164,-0.00036742576,-0.05631576,0.0058170357,-0.059974663,0.089436665,-0.040756654,-0.025714148,0.07484262,0.023677891,-0.029783357,0.06593783,-0.024784243,-0.035542946,0.0060526747,-0.016446216,0.056458157,0.018618345,-0.05030772,-0.13047767,-0.03475494,-0.043177728,0.015087429,-0.05962913,0.033259615,-0.06448639,-0.058651567,0.02724898,-0.08491092,0.0275724,0.06390313,-0.022935642,-0.0004226864,-0.078878574,0.044937234,0.041674323,0.009501301,0.103761435,-3.4762333e-08,0.038272414,-0.033376515,0.014124621,0.0059505375,-0.046729,-0.026127957,-0.013864149,0.021488504,0.06361525,-0.05974901,-0.048885275,0.060024984,-0.044952337,0.004074425,0.011257898,0.07060163,-0.14082865,-0.10050246,-0.025010096,-0.059488777,-0.04403381,0.016262786,-0.07908627,0.091413885,-0.0645169,-0.048321784,-0.019361695,-0.09310772,0.025350515,-0.024747591,0.04325816,0.024975516,0.04294082,-0.0771078,-0.04073221,0.0042773206,-0.013345395,0.031665955,0.06974128,0.037255034,0.032068994,-0.08040192,-0.079431236,0.044100456,0.009741231,0.06748501,-0.08870925,0.118892245,-0.04618221,0.0085517615,0.03608217,0.026077583,-0.036046606,-0.012366762,-0.051145215,0.032069705,-0.036916114,-0.053347025,0.05616159,0.06988161,-0.023236869,0.0207403,0.07917812,-0.104259975 +2.4.1.54,Requires phosphatidylglycerol.,384,0.99999994,-0.007073853,-0.0050774333,0.00071038515,0.017685657,-0.06459897,-0.049132533,0.04617296,0.050763767,0.009020038,-0.02127378,0.013797824,-0.014060801,-0.04142997,0.07929664,0.023762252,-0.049390413,-0.0026257106,-0.031542286,-0.010348477,-0.03436779,0.051423863,0.07422897,0.036105182,0.038610075,-0.0790393,-0.02320045,0.013457514,-0.0020201025,0.03846896,0.01863317,0.07678592,-0.030903379,-0.020715587,-0.09231238,-0.023380676,0.016669024,-0.018739114,0.04516735,-0.036419977,0.015646279,0.076027945,-0.059478268,-0.036016032,0.024702024,0.017152928,0.05185885,-0.040663924,0.049861107,0.07357505,0.03732485,-0.07727439,-0.07665577,-0.02920256,0.00720237,-0.062098347,0.034534372,-0.08121817,0.023763958,0.02066927,-0.00951456,-0.09689925,-0.009759162,0.0036698582,0.063918054,-0.050308283,-0.005819688,-0.009955045,-0.05253971,0.07427693,0.15143546,-0.03144288,-0.053093825,0.015384035,0.094527446,-0.025094207,0.0021757365,0.035205655,-0.090303816,0.06284881,0.016068013,-0.014050568,-0.009872796,-0.048558667,0.121235274,0.05569068,0.05667299,0.0062942575,-0.05859999,-0.08794095,0.0144365,-0.004576107,-0.075813845,0.021727236,0.02153596,0.023167908,-0.017906206,-0.03149003,-0.06029581,-0.05540247,0.026911829,-0.04152196,-0.016151538,0.045616504,0.033397276,-0.011242433,-0.010687682,-0.03182706,-0.089846015,0.008955744,0.021232912,0.028241422,-0.0012875706,0.09238825,-0.06316266,-0.023670444,0.056579724,-0.0039786184,-0.03403289,-0.03397203,-0.047738355,-0.058369823,-0.08801743,-0.039356314,-0.06688616,-0.043584365,-0.00751469,0.0012312626,2.2511126e-33,0.03251159,0.045232367,0.005686279,0.016925123,-0.014375513,0.030528588,-0.03457081,-0.035110936,-0.045619354,-0.04531681,0.040758055,-0.08441311,-0.039704535,0.08116712,-0.04708155,-0.03506376,0.020782445,0.09708887,0.04906214,-0.05579077,-0.0050096335,-0.047884576,-0.013930414,-4.4477183e-06,-0.04969895,0.116619304,-0.020379828,-0.03279717,0.08084515,0.010090611,0.028209798,0.013120042,-0.0044493717,-0.06844286,-0.038233276,0.07574695,-0.023278382,-0.05492344,-0.017110644,-0.017315403,-0.010214633,0.0184494,-0.03794943,0.04155865,0.042572614,-0.015611906,-0.092578776,0.09921742,0.060246624,0.0066992124,0.0008833127,0.0006632218,0.0888345,0.031039564,-0.00072800915,-0.016128475,-0.02954011,-0.061746746,0.034844838,-0.0004920495,0.018784922,0.112730466,-0.050253354,0.07645108,0.017517941,0.00079988333,-0.0549503,-0.04372031,-0.08165293,-0.057892043,0.02089055,0.0069120075,0.014661006,0.016783874,-0.04160971,-0.019273756,0.07743934,0.0038887472,-0.015959712,-0.015741631,0.06991252,-0.05243449,0.06335033,0.054651197,0.018983915,-0.018855665,-0.045646034,0.001073616,0.0045143063,-0.015854577,-0.07631947,-0.0875037,-0.04188563,0.08876926,-0.056833398,-3.331954e-33,0.00961317,-0.040988076,0.06847324,0.034162704,0.06544764,0.044029724,0.05504961,-0.009013064,0.11711457,-0.0034940923,0.011920947,-0.064248346,0.019530509,-0.011354123,0.03415383,0.06087496,-0.025719278,0.0035312693,-0.030452434,0.033104017,-0.015017906,0.06707704,-0.024127115,0.17299367,0.042980313,0.001158463,-0.07486516,0.028810818,-0.14321077,0.067395315,0.023636073,-0.040546034,-0.1062998,-0.122564934,-0.094322585,-0.008396235,-0.060929716,0.019204263,-0.069296956,-0.012835114,0.013205544,-0.013569694,0.113016665,0.02650103,0.031211967,0.03721956,0.024693074,0.005776239,-0.006636352,0.078236714,-0.04781265,0.042841747,-0.05566169,0.07830183,0.04195457,0.081817485,-0.04602097,0.039954275,-0.0044525643,-0.085884474,6.9292895e-05,-0.07851576,-0.03981449,-0.013023133,0.066867165,0.037276972,0.03864645,-0.019348718,0.060928985,0.027991302,0.0033560055,0.08122692,0.021464016,-0.019491626,0.00036997377,0.05168079,-0.08673006,-0.025137912,0.0060910997,-0.017470097,0.01067501,-0.023808349,0.048902743,-0.05837957,0.04978032,-0.027392462,-0.011045657,-0.09228512,-0.048669096,0.054339867,-0.037993327,-0.06379347,-0.045120075,-0.0024227288,0.025656026,-2.3350442e-08,0.020315962,-0.028788073,0.018494813,-0.078267485,-0.057747427,-0.050088976,0.1064623,0.007096116,-0.029288527,-0.057629183,0.0055854423,0.05398298,0.04341622,0.059934083,0.07356897,-0.04398408,0.010838141,0.12660547,-0.057797503,-0.08704486,-0.08624227,-0.05329577,0.0062541487,0.06291679,0.012607731,-0.021836862,0.11065732,0.023541676,-0.02427856,0.073545545,0.035130303,-0.0077167926,-0.048442967,-0.001547914,-0.02290427,0.03122058,-0.0012961489,0.03182375,-0.06011634,0.081466734,-0.048409093,0.07468008,0.03778708,0.03461266,-0.02281813,-0.03892996,0.022305628,0.03643816,-0.019042827,0.029578859,0.025617195,-0.0023977798,-0.003683372,-0.046295602,-0.07545981,-0.041603263,-0.005045481,-0.011437557,-0.04277913,-0.0021932886,0.036364492,0.017242081,0.20304199,-0.016540334 +2.4.1.56,"Transfers N-acetylglucosaminyl residues to a D-galactose residue in the partially completed lipopolysaccharide core [cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase), EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)].",384,1.0,-0.012846529,-0.108760014,-0.0778529,-0.016879125,0.02929425,0.0027847236,0.008273772,0.02680815,0.027791219,-0.0020771993,0.04467037,0.023863165,-0.05575822,-0.024093635,-0.092875175,-0.056087855,-0.030531323,0.0042145406,0.003988212,0.049830113,0.11685269,0.015375879,-0.02427617,0.030083222,0.082557805,-0.038915988,-0.008218344,-0.094228305,-0.012608858,-0.05135348,-0.029185131,-0.06740221,0.03262168,-0.053887077,0.07789652,-0.0028034663,0.0071544014,0.0052134935,0.07977427,-0.041350946,0.030545067,-0.017022874,0.025570737,0.010075506,-0.0015461604,-0.009773277,-0.040308703,0.0610288,0.039019432,0.034107186,0.07340722,-0.07183406,-0.09449008,0.0075474894,0.034069702,0.03605101,0.005923769,-0.05193697,-0.0049405796,0.08875942,-0.0070922906,0.026479054,0.012615715,-0.03178174,-0.038826957,-0.10060148,0.15279132,-0.077449754,0.008173547,-0.011774271,-0.08268916,-0.038322076,-0.03455584,0.005472233,0.037346184,0.040725015,-0.019208763,0.0129038235,0.038677372,-0.035853557,0.08891123,-0.013473798,0.032761008,0.06754229,-0.024965905,-0.06457137,-0.0022149242,0.022299688,0.01782399,0.03586705,0.0027816002,-0.0754006,0.054711666,0.0029795093,-0.052581687,0.0142688695,0.029818695,0.04040855,0.077942215,-0.06134527,3.866637e-05,-0.022948543,0.019950194,-0.06950763,-0.08067709,0.07956086,-0.0070983493,0.03195923,0.038597457,-0.005832473,0.0028536415,0.0019275866,0.052570622,-0.02394959,-0.09852412,0.019955454,-0.0114575755,-0.10029777,-0.06711966,-0.019893326,0.003647381,-0.032282423,0.13066521,0.031124108,-0.016569963,0.08209427,0.030633131,5.3124256e-33,0.023979861,0.03630641,0.038552903,-0.028801791,-0.023118448,-0.037482705,-0.09796451,-0.06478439,-0.025796782,0.0040438697,-0.05576527,-0.088054985,0.008673399,0.043144897,-0.037685275,0.12280507,0.07445045,-0.0354641,0.06183464,0.021043807,-0.029773433,0.05531187,-0.044564765,-0.019699184,0.08986167,0.06462532,-0.08097301,0.038722474,0.041543275,0.007425352,-0.009588796,-0.04350549,-0.032027952,0.039941702,0.08680599,0.01102879,0.044070456,-0.059521895,0.045363177,-0.0079981545,0.058108684,0.041860156,-0.0037206456,-0.024315791,0.018932521,0.029485814,0.0020032937,0.009401573,-0.0021931124,0.070601344,-0.016756225,-0.048967335,0.059139777,0.06364723,-0.0271705,0.027979173,-0.049582053,-0.059891764,0.066932224,0.06253289,-0.01065708,0.081553765,-0.05740652,-0.043003213,-0.0061127483,0.01928483,-0.08456741,0.02062098,-0.036878057,0.012214428,-0.018602544,-0.08272873,0.021957757,0.06334077,0.09108612,-0.06326523,-0.028934587,0.088932425,0.026246296,-0.005014135,0.020409001,0.12218362,0.012708526,-0.07987622,-0.014642254,0.03811568,-0.04451396,-0.033708453,-0.0045230347,0.017983247,-0.081247315,-0.030663708,0.022652492,0.056728493,-0.04748606,-7.02532e-33,0.07278297,-0.06658094,0.025678305,-0.06637785,-0.008525089,0.07066856,0.036432497,-0.0039221337,0.08377,-0.0030447743,0.039383993,-0.030490858,-0.012121861,-0.030060602,0.065407686,-0.0041521327,-0.055482432,0.05908619,-0.08144776,-0.02777514,0.034165103,-0.021320738,-0.0003940852,0.049596004,0.017403182,-0.05267081,-0.049816668,0.055454765,0.0077151465,0.0510926,-0.01339502,-0.057108313,-0.034248777,-0.057337623,-0.041989252,-0.047621932,-0.030837253,0.047024846,-0.085633814,0.03494231,-0.0029725186,0.07642721,0.05830018,0.004977565,0.07326323,0.040505785,-0.08086249,0.0069955057,-0.0140797105,-0.05461025,0.013903791,-0.030791108,0.003766976,0.0959422,0.013509506,0.099641755,0.122365,0.11923467,0.04553164,-0.05049626,-0.052849323,-0.019275177,-0.014155933,-0.07172402,0.10645767,0.025211055,-0.0041300333,-0.001372069,0.0014150904,-0.032130595,-0.05103333,-0.027310377,0.0048446106,0.058853112,0.05625355,-0.031870067,-0.14551222,-0.07654128,-0.023408089,-0.020448701,0.08503313,0.005513708,0.0068719736,0.002297886,2.2069205e-05,-0.034739025,-0.00010340379,0.06295549,-0.037752684,0.006683613,-0.06252773,0.003241663,-0.018209986,0.0059123226,0.024686294,-4.4094886e-08,0.018289724,0.032042924,-0.0037620135,-0.10705879,-0.007301739,0.0010537958,-0.053694975,0.008712656,0.0365396,-0.035760604,0.010835205,0.11949153,-7.2615e-05,0.04202852,-0.08922347,0.0046901866,0.012645709,-0.0032003599,0.004051326,0.03431231,-0.06313705,0.0037488735,-0.060548395,-0.032287993,-0.011221769,-0.09620947,0.09951864,0.06633603,-0.061654497,-0.016474236,0.008196598,0.015040245,-0.05780189,-0.03288198,-0.018653989,-0.008498164,-0.011013313,-0.055771142,0.055220123,0.09779505,-0.006692086,-0.055421773,0.025908668,0.008778979,-0.012570761,-0.025534503,-0.013264041,0.0068519833,-0.034320276,0.09579153,-0.014882968,-0.073063456,-0.14413093,-0.0670422,0.0070505706,-0.11669882,0.0071457434,-0.016192332,0.062352184,-0.038965315,0.027784182,-0.033042837,0.12282171,0.0028094123 +2.4.1.58,"Transfers glucosyl residues to the backbone portion of lipopolysaccharide [cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase, EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)].",384,1.0000001,-0.027585,-0.10588009,-0.08487142,-0.024535688,0.011169969,0.00068389566,-0.01191325,0.029669726,0.041669454,-0.026155572,0.08354579,0.018365117,-0.030602567,-0.047161464,-0.09215421,-0.06306831,-0.04175856,-0.011737117,-0.037902117,0.04651213,0.087057665,0.01596674,-0.046034545,0.036966812,0.043979734,-0.027412504,-0.0029791635,-0.08751936,-0.016422441,-0.07924867,-0.040779665,-0.07552232,0.01772396,-0.07215752,0.06993812,0.0022888996,0.0026308293,-0.010451831,0.0861332,-0.022692038,0.015082159,-0.034461837,0.033697035,-0.004775312,0.013435197,-0.006513925,-0.0013082891,0.048747037,0.0486659,0.05637891,0.08036786,-0.07566277,-0.098383084,0.017374555,0.014595648,0.036744405,-0.012439541,-0.04795145,-0.016340032,0.106574535,-0.026526691,0.022312513,0.0032970244,0.0048162276,-0.0532751,-0.08897081,0.15385531,-0.08020598,-0.003056071,-0.00425151,-0.09756678,-0.04271507,-0.012366052,0.024061665,0.036943905,0.059711233,-0.010568236,0.02206929,0.080741204,-0.03768811,0.099155895,-0.019952886,0.016711414,0.09090999,-0.011391131,-0.0594834,-0.030212922,0.014710424,0.0003255202,0.020679116,0.008785288,-0.08348812,0.049431052,0.007831353,-0.06413106,0.040348206,0.019584917,0.0406425,0.095716536,-0.050100867,-0.017037246,-0.013906327,0.04083805,-0.058934264,-0.0605124,0.08073367,-0.0036842658,0.030033136,0.03038966,-0.008216414,-0.0061768102,-0.00091769727,0.038393516,-0.052754484,-0.06396719,0.01884049,-0.005094367,-0.08982872,-0.085899614,-0.023462854,-0.0028580832,-0.023662005,0.1324191,0.039022196,-0.026446674,0.07049553,0.030819753,6.3950566e-33,-0.001893702,0.014665133,0.04646559,-0.038817953,-0.0031522405,-0.033706322,-0.0794314,-0.050410952,-0.05591944,-0.008374786,-0.028366076,-0.08181546,0.004314355,0.0415749,-0.03336359,0.12704039,0.06621308,-0.03021201,0.051076893,0.013522497,0.008395489,0.06969898,0.002251624,-0.01389352,0.11826127,0.07041826,-0.09479232,0.0023571162,0.0031002408,-0.003200374,-0.020812761,-0.025663143,-0.066370346,0.03312504,0.08868738,0.00089716585,0.044088192,-0.07207989,0.049301125,0.021231528,0.04994026,0.023712968,-0.015506829,-0.029848345,0.026639696,0.02269741,-0.012902187,-0.007763184,-0.010317506,0.054267976,-0.0074389153,-0.03872711,0.060651813,0.08752774,-0.025237264,-0.008134824,-0.04359136,-0.045155868,0.04616705,0.058752093,-0.009278251,0.11428608,-0.052445535,-0.036530472,-0.01081894,0.0055313674,-0.09619098,0.01377907,-0.042456005,0.04080582,0.032898914,-0.074999385,0.006733403,0.06956099,0.073275425,-0.047246527,-0.05591268,0.07180125,0.02003,0.0135756405,0.0041673593,0.111079454,0.031677645,-0.07014238,-0.038921554,0.025955984,0.00093820924,-0.04093151,0.008007928,0.014039093,-0.07525801,-0.019220367,-0.001548663,0.048760545,-0.03976151,-8.45438e-33,0.10484421,-0.057150457,0.040912513,-0.08344528,0.0060336366,0.05937385,0.028218599,0.0085594775,0.04947262,0.019259067,0.03377743,-0.03223605,0.0057927985,-0.043079603,0.09636143,-0.019140322,-0.054241117,0.05285183,-0.070526496,-0.044694107,0.03825507,-0.025431998,0.0131611135,0.058294225,0.0390306,-0.0697576,-0.040247805,0.06056131,0.0011087364,0.06901688,-0.075101316,-0.0497111,-0.02477248,-0.042288,-0.028446952,-0.0051769437,-0.03128721,0.05306732,-0.035689276,0.008481656,0.009220427,0.07039905,0.07160334,0.005468422,0.0662937,0.06783173,-0.07681728,0.013408072,-0.02517323,-0.06405984,0.03569297,-0.0044056927,0.010123063,0.098396316,0.027214654,0.10105421,0.103436604,0.08429818,0.036389027,-0.04990919,-0.071682595,-0.03824006,-0.043438345,-0.059343208,0.09948479,0.027797831,5.6351535e-05,-0.034724254,0.013795599,-0.017691594,-0.033053298,-0.042850625,0.01323357,0.057719465,0.06763958,-0.017090386,-0.14067787,-0.07617933,-0.017206272,-0.02000487,0.09934924,-0.032731067,0.04608997,0.0074955593,0.02598892,-0.03500096,0.0037316529,0.045796577,-0.026545227,0.016190093,-0.039226916,0.0019291956,-0.0345306,-0.0060421075,0.029741224,-4.6924786e-08,0.013315345,0.014476138,0.025941564,-0.1032164,-0.010147463,0.010407087,-0.05350239,0.008226436,0.03366621,-0.013081718,0.013665089,0.11653306,0.0014362651,0.042692866,-0.0947219,0.012605316,-0.0064133764,-0.0023762393,0.013597651,0.002226737,-0.082898,-0.0075511024,-0.059203845,-0.019136783,-0.010220291,-0.09802016,0.064009644,0.029528845,-0.058251884,-0.035468824,-0.0066604773,-0.009878588,-0.06153771,-0.04829222,0.0043235687,-0.0030379032,-0.010179643,-0.07140006,0.044289622,0.09164944,-0.030500367,-0.052450296,0.017202608,-0.001703492,-0.00281318,-0.01404671,-0.002566959,0.011206469,-0.036439434,0.06729408,0.0014850345,-0.0877103,-0.10793331,-0.071729906,-0.01830375,-0.11012488,0.00086437,-0.008664883,0.06299172,-0.020078255,-0.0104255555,0.00021505858,0.16392948,-0.014765603 +2.4.1.60,"The enzyme from Salmonella participates in the biosynthesis of the repeat unit of O antigens produced by strains that belong to the A, B and D1-D3 groups. The enzyme is able to transfer abequose, paratose, or tyvelose, depending on the availability of the specific dideoxyhexose in a particular strain.",384,0.99999994,-0.0066333706,-0.07549608,-0.039365023,-0.021300286,0.0055418783,0.037592795,0.051056765,0.011090889,0.042629212,-0.074335694,-0.024493672,0.014042307,-0.03569618,0.028633943,-0.023664378,0.061151538,-0.026994662,0.055940207,-0.0782885,-0.11208976,0.11759958,0.00041785566,0.023694854,-0.006782007,0.0045346185,-0.0025774406,0.057677876,0.03215151,0.03711161,-0.055775687,-0.07765847,-0.09321695,0.044039965,-0.05351782,0.06761218,0.022313224,0.05933701,-0.021623267,0.08026195,0.035965063,0.064758234,0.016912013,-0.014886028,-0.0035911568,-0.08029012,0.024421733,0.009979995,0.06305412,-0.014437923,0.007073634,-0.063333146,-0.0742804,-0.023599094,0.010049402,0.07103582,0.03286079,-0.050952278,-0.03414435,-0.045018718,-0.057948604,0.015082916,-0.025651991,0.06786375,0.04133321,0.04436599,-0.093633406,0.043991547,-0.013909863,-0.055830672,-0.08579037,-0.042037718,-0.041682445,-0.035618994,0.05220027,0.009564218,-0.014313801,0.08249663,-0.03813151,0.074279405,0.0057744565,0.0015051785,-0.048759352,0.027030447,0.122338794,-0.009212749,-0.02625553,-0.0013858444,-0.00089664804,0.025243444,0.06234643,-0.01401379,-0.11769732,0.03663761,-0.11495657,-0.021469284,0.013254581,0.03737175,-0.016675048,0.09663655,0.002223209,-0.07032478,0.016396353,0.014706129,-0.051230066,-0.035254035,-0.04513752,-0.011771872,0.075206876,0.026258826,0.020303624,0.04434415,0.004554103,0.094220534,0.03655708,-0.07206623,-0.0027704053,-0.011845984,-0.07798358,-0.046347458,-0.06471431,0.014703142,-0.053090185,0.06592488,0.10820727,0.033668924,0.08093515,-0.028803134,8.012007e-35,0.034974463,-0.004021991,-0.015991809,-0.016825065,-0.0068197013,-0.05383056,0.0050304662,-0.020202698,-0.060560826,0.030983219,-0.12071047,-0.07979981,0.032413337,0.05721832,0.011973874,-0.01637473,0.024187468,0.022918576,-0.026587296,0.062113095,0.034614485,0.052797608,0.02534343,-0.013601848,0.0028891852,0.023812534,-0.049434938,0.045015886,0.027482754,-0.017321555,0.04642601,-0.060896784,-0.123897575,0.028989363,0.06840263,-0.015653428,0.007189237,-0.0074625346,-0.023854354,0.04125318,-0.03886085,0.05126592,-0.002934245,-0.02795776,0.056206875,-0.091148674,-0.02083614,0.013805327,0.05779407,0.06397234,0.0196408,0.017152436,0.12714836,-0.0946261,-0.011589979,-0.038260136,-0.011462059,0.0054835915,0.03195902,0.050796647,-0.03673526,0.017364645,-0.04753263,0.034204982,0.035846915,0.040381003,0.03182706,-0.060309555,0.014522718,0.04987239,-0.021962525,-0.04638373,-0.023530891,-0.014721344,-0.06469875,-0.038720474,-0.056922402,-0.050959285,0.049372148,-0.110062644,-0.026915954,-0.031763595,0.031606834,-0.013214314,-0.13175417,0.03434518,-0.03548838,-0.074957214,-0.032596014,0.0044382843,0.032036018,-0.03367153,-0.062404532,0.040881246,0.043784313,-1.6182974e-33,0.028634714,-0.044370923,0.004762866,-0.120567836,-0.097562924,0.072181575,0.00092912005,0.026286524,0.017181912,0.01668857,0.011112265,0.014380195,-0.030575864,-0.004812905,-0.08424176,0.019367307,0.006776272,0.0710387,-0.08939544,-0.09263721,0.008377281,0.08029317,0.02234073,-0.00068515213,-0.011621096,0.070470676,-0.016913725,0.10800769,0.019365229,0.017833006,0.014436934,-0.004527305,0.034464646,-0.02665274,-0.01120054,0.023406528,0.03429529,0.05390072,0.0059915027,0.02811636,-0.0051448643,0.049077608,0.036055796,0.09199172,0.016025905,0.1088936,-0.08517785,0.014136194,0.056056954,-0.03008546,-0.015686741,-0.009201792,0.062041152,-0.0070060743,0.016726453,0.017354906,0.018378664,-0.03476353,-0.05642382,-0.06592983,-0.040577304,-0.07874011,0.12585582,0.016637364,0.04375019,0.06539693,-0.054154433,0.015687186,0.007786271,0.02695573,-0.022634044,0.046886384,-0.026066152,-0.04260121,-0.038421508,-0.07415108,-0.089304745,-0.034327913,0.06901945,0.025345052,-0.027850468,-0.016092293,-0.056843843,-0.0032287613,-0.02494088,-0.047877572,0.03296177,0.10287858,0.04839546,0.031684313,-0.029952124,-0.015781794,-0.037676755,0.025364902,0.054319248,-3.604574e-08,0.05954821,-0.07894564,0.0025347564,0.004219799,-0.047234897,0.03565535,-0.06372666,0.010443999,0.07661835,-0.034731064,-0.0748747,0.12314641,0.0188658,-0.029275347,0.044224784,0.0092513,-0.016722184,-0.046388127,-0.051572017,-0.059764814,-0.027063252,-0.039614614,-0.07867288,0.051489573,0.07521701,-0.041746236,-0.043038175,0.03702836,0.03397283,0.041744046,-0.05731695,0.034895428,-0.035727076,0.0033174832,-0.074091665,-0.0023046474,-0.05309201,-0.01721015,-0.011450299,0.03905849,0.058907364,-0.027628535,-0.08494122,0.021893105,0.031397842,0.048698023,-0.05665082,-0.016770242,-0.022804422,-0.037116185,0.046307288,-0.058460478,-0.009662489,0.042784516,-0.12891714,-0.016759502,-0.032801885,-0.041207433,-0.0018694171,0.022903167,0.059678115,0.08836934,0.19676636,-0.07593566 +2.4.1.62,"The substrate is also known as gangloside GM2, the product as gangloside GM1a",384,0.99999994,-0.050700683,-0.08296664,-0.023003317,-0.019768074,-0.0027366383,-0.074152276,0.009523091,0.10260324,-0.08197549,-0.028202778,0.033613183,0.014304656,-0.059946295,-0.005612241,-0.017129656,0.00467605,0.08004213,-0.004158909,0.10824379,-0.0732644,0.092617,-0.07182896,-0.023707675,-0.0032947066,-0.0399337,0.018011948,-0.01765941,0.015220597,0.04153585,-0.07020884,-0.0065056435,-0.025027948,0.07641714,0.0006874791,0.020368174,0.04637109,-0.01605131,0.0021644693,-0.0117449695,-0.03367201,0.045771763,-0.04179031,0.045535013,-0.06367402,0.006318039,-0.03191266,0.0060445084,0.038377315,0.052513827,-0.029448528,-0.0039506466,-0.07758545,-0.028798828,0.010826139,0.051555682,-0.024389278,-0.07115952,0.0128814895,0.0030841152,0.052673716,0.0116806105,-0.0058131157,-0.08378612,-0.04017379,0.007992216,-0.03349638,0.027295386,-0.07960697,0.011260236,0.04464468,-0.020053301,-0.04869411,-0.06124465,-0.016123593,-0.044524405,0.05948026,0.027461298,-0.040330168,0.08193378,-0.013563278,0.016557619,0.07609439,0.03037527,0.0252554,-0.055518553,0.064241394,0.013140762,0.005714977,0.010659242,-0.028486917,-0.010276083,0.05951865,-0.010978556,0.014023085,-0.067850694,0.026492512,0.030909918,0.0077559142,0.08505069,-0.0025110159,-0.011630979,0.023110371,-0.03273599,-0.03295197,-0.10198588,0.03393508,-0.040651605,0.0841697,0.064261034,0.007197398,-0.052110538,0.086818986,-0.017684296,0.054217383,-0.07962809,0.0071839457,0.05765817,0.014996159,0.0030933598,0.0022151342,0.04466548,0.030250074,-0.012883685,0.036689457,-0.03435807,0.022353176,-0.025918117,-1.1029606e-33,-0.004652482,-0.024354534,0.00080733804,-0.070219934,-0.07154688,0.010901341,-0.04839369,-0.044916432,0.007759532,0.014230149,-0.056313913,-0.07491437,-0.059731975,0.11704813,-0.0073799896,0.0049874466,-0.0034798814,-0.007063912,0.09545635,-0.022142556,-0.116780646,0.027717067,0.039463155,-0.016973808,0.11436159,0.0068434514,-0.026117321,-0.03596526,0.037054643,0.014566885,0.039657567,0.017163808,-0.06871487,0.0029717758,-0.014356153,-0.006104914,-0.047309928,-0.021430224,-0.018752405,0.024373468,0.028256038,0.053242095,0.04215275,-0.059012476,0.036984764,-0.079674035,-0.01957733,0.00830965,0.054687418,-0.017165704,0.022539923,0.027532617,0.021334283,0.0027558813,0.018160079,0.032075733,0.02083766,-0.027441934,-0.025878537,0.08024811,-0.0091484655,0.11147049,-0.005462887,0.019794066,0.004580883,0.027275262,-0.06326432,-0.020501126,-0.07378071,0.016138282,0.011530894,-0.027256504,0.039209273,0.10813865,-0.038998764,-0.06770798,-0.00635052,0.011832726,0.054024957,-0.0074739046,-0.08308174,0.018917948,-0.04245834,-0.07230945,-0.15375029,0.052685793,0.040539436,-0.07198205,0.0065972656,-0.0031602853,-0.08845807,-0.046363387,-0.027339663,0.062069345,-0.012500113,-2.616597e-33,0.026256151,-0.026629247,0.069302075,-0.07934011,-0.043905962,0.028151188,0.02374783,-0.014520299,0.036180016,0.110704035,0.027012141,0.08616015,-0.013925034,-0.028902965,0.047017977,-0.004488203,-0.017227205,0.05044504,-0.055812813,-0.058064252,9.134505e-05,0.12163246,0.06016456,0.05014349,0.074444704,-0.06046373,0.04217298,0.07924919,0.038533732,0.05105658,0.009638985,0.032033306,0.040728804,-0.050691523,-0.008565156,-0.024516197,0.023808599,-0.06244034,0.009779545,-0.042668413,0.023017792,0.106350735,0.011277642,0.024289625,-0.037800755,0.09416329,0.02983869,-0.005418435,-0.00027748465,-0.09163529,-0.008119387,-0.046082247,-0.026528556,-0.0028411164,0.061743032,0.03775757,0.024206076,0.05904043,-0.050324455,-0.08145486,0.039380156,-0.007876875,-0.012800261,-0.09466609,0.078421764,0.04673407,-0.002141155,-0.023398286,0.019162454,0.06011352,0.11063785,0.05594456,-0.026287744,0.018027995,-0.04261416,-0.025557538,-0.14836575,-0.0025756056,-0.07047992,-0.045852035,0.08824112,0.07404875,-0.0068501555,0.024322204,0.09533772,-0.06051003,0.013620956,0.15405007,0.010108371,0.08628045,-0.023834206,-0.058363743,-0.06867292,0.1133514,-0.0044405083,-2.4442373e-08,0.07298619,-0.08631198,-0.019804697,-0.120809674,-0.12773612,0.059340015,-0.03348032,-0.022636354,0.055420287,-0.064261444,-0.041845057,0.08897204,0.008981291,0.05694434,-0.033775043,0.037585776,-0.048625503,-0.035336073,-0.035177536,-0.010694533,-0.07377813,-0.038486533,-0.04643985,0.045890436,-0.033382125,-0.10619506,0.009530486,0.058424406,-0.035117563,0.00039093423,-0.016062412,0.038293503,0.04199576,-0.024373338,0.025575584,0.021530874,0.014686095,-0.022459965,0.05785415,-0.022131762,0.045745455,-0.06791373,0.013498294,-0.0063724364,-0.009796571,0.026266653,-0.04429121,0.055962984,-0.058330655,0.03447404,0.01020982,-0.04080106,-0.04187229,-0.05295615,-0.04934216,-0.069427654,-0.104041904,-0.04234802,0.056071285,-0.11211567,0.012306436,-0.007194702,0.12861311,-0.016375037 +2.4.1.63,The enzyme glucosylates the cyanohydrins of butanone and pentan-3-one as well as that of acetone.,384,1.0,-0.13606453,-0.035645194,-0.06316699,-0.03275982,0.079616874,0.050527025,-0.058308993,-0.040743776,-0.003413064,-0.031411007,0.07604187,-0.045605488,-0.09592492,-0.028325744,-0.08075628,0.05091551,-0.06040929,0.067213066,-0.009745325,0.00894651,0.044226505,0.01221805,-0.045465894,0.010984623,0.07340056,0.034404702,-9.812983e-06,0.020211017,-0.01217776,-0.043370165,-0.075591154,-0.08057963,0.0026148893,0.0008905188,0.08893416,0.016627876,-0.070089795,-0.010125511,0.053508274,-0.008465312,-0.009177958,0.035274383,-0.023378966,0.0029683134,0.0029007066,-0.089476876,-0.025757795,0.008985795,0.02629992,-0.018741721,0.052074753,0.003839987,-0.012389592,-0.00091483985,0.040778402,-0.02517949,-0.09864279,-0.0024874457,-0.023512186,0.067317136,0.04762596,0.018558793,-0.082563825,-0.03276008,-0.03942333,-0.041411515,0.004027813,-0.04020883,0.033086028,-0.002662938,0.006677765,-0.034289636,-0.030684827,0.025496082,0.053081337,0.04099144,0.0060973684,0.0027251833,-0.04064013,-0.023808183,0.12368577,0.04337926,0.059606303,0.093151264,0.09065855,-0.035146944,-0.010374879,0.05505554,-0.030804625,0.01257046,0.039371863,0.008359191,-0.091655605,-0.05198084,-0.021905903,0.006253547,0.08976909,0.0126299765,0.047210705,0.015687063,0.0014856817,0.03208686,0.008525932,-0.097091615,-0.018847676,0.07337627,-0.0051116184,-0.0038172526,0.049819738,0.021427892,-0.023736484,-0.013834211,0.001448768,-0.015590188,-0.040126693,0.03226483,-0.017962473,0.014738408,0.00038547203,0.10400636,-0.018063096,0.055317666,0.03814788,0.1229491,-0.03710562,0.03738863,-0.024388291,-1.502388e-34,0.040512364,0.011142496,0.00025556656,-0.011379855,0.005316158,-0.03514585,-0.071029775,0.009288376,0.0073857857,-0.075715825,-0.06834302,-0.042819384,0.019051095,0.035528075,-0.0465749,0.01276011,-0.035769127,-0.08581998,0.054580644,-0.015185965,-0.010742018,0.055995386,-0.09394271,0.03227216,0.024470242,-0.039561093,-0.014501272,0.0866692,0.03515204,-0.034396525,-0.022996267,-0.07853256,-0.03340403,0.023948086,0.060584247,0.085272714,-0.0038898631,-0.040907204,-0.012201421,0.05696418,-0.041450977,-0.013085675,-0.05531947,-0.045164894,-0.021809997,0.017294565,-0.05407287,-0.006355153,0.026156483,-0.00284785,0.036587194,-0.0442889,0.030939696,0.057897475,-0.04196547,0.021690948,-0.02528228,-0.0016766712,0.041954167,0.020008529,-0.04602479,-0.010689107,-0.0041723954,-0.006440638,-0.020773502,0.061386153,-0.13920678,-0.009048066,0.0038256366,-0.026132382,-0.063342385,-0.04159109,0.11513491,0.029574858,0.02283434,0.034840785,-0.026414381,0.055023327,0.013340826,0.024694592,0.003013994,-0.06492669,-0.024239691,-0.0067020655,-0.11293519,0.0037936186,0.011060234,-0.0626567,0.059259664,0.029139275,-0.04046871,-0.051241845,-0.028367186,0.015113989,-0.00022215444,-3.4342817e-33,0.078067675,-0.0759702,0.10169886,-0.035958543,-0.048558217,0.11279753,-0.010516986,-0.06353556,-0.030209305,-0.0072564785,0.016302131,-0.027288403,0.0029538292,0.030469395,0.026692938,0.08421403,-0.04725214,0.11984632,0.017133689,0.07037293,-0.07589778,0.064655304,-0.018145759,0.049080566,0.014414887,0.008830045,-0.009586409,-0.031758174,0.034391224,0.07122421,-0.004612828,-0.033849336,-0.018710552,-0.028383244,0.007231392,0.06324573,0.027437938,-0.035243224,-0.084194854,0.075482406,-0.040677417,0.00010690683,-0.020165041,0.027264465,0.1267452,0.0734297,-0.014034374,-0.037848514,-0.10296005,-0.080546774,0.08981687,0.022710543,-0.010761321,-0.012485686,0.055087678,0.0547949,0.09115014,-0.042820066,0.051140755,0.04307742,-0.035009284,-0.07889452,-0.037308946,-0.019851582,0.01891742,0.049207322,-0.007775076,0.047236186,0.00090951816,-0.01679389,0.005514061,-0.013821762,0.12899467,0.07843891,-4.675074e-05,-0.028330559,-0.029188646,-0.076067306,-0.073297,-0.09287766,0.0038077112,-0.07219842,0.0072469097,0.038027566,-0.12915811,0.027138991,0.08424953,0.06439534,-0.056884773,0.016551752,-0.023346806,0.074536435,-0.05197082,0.10018343,0.048813365,-2.7252293e-08,0.0999751,-0.0073960987,0.06405925,-0.08242624,-0.06309384,0.03276065,0.1412579,0.033262607,0.0017804396,-0.014126021,-0.015769921,0.08765203,0.004022397,-0.028314143,-0.026396701,0.033818655,0.011094348,-0.036248434,0.030553527,0.029484741,-0.0906401,0.062253904,-0.07490888,-0.051659077,-0.063798845,-0.071934894,0.06089913,0.15180784,-0.041438848,0.026158584,0.014178703,0.01807316,0.0028846902,-0.05961351,-0.006591367,0.021860488,-0.017478906,-0.08471149,-0.020047294,-0.0022016389,-0.07023835,0.022026552,-0.056877054,-0.007709605,0.018412707,-0.056938775,0.03187539,0.057947297,-0.0059437477,-0.0130604515,-0.012084333,-0.008323216,-0.037409734,-0.056214653,-0.028870288,-0.03455138,-0.016265674,0.0034679992,-0.06824099,-0.08317614,-0.0979451,-0.040798053,0.13687058,-0.011923628 +2.4.1.65,"This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-alpha-fucosylation of the GlcNAc in beta-D-Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities.",384,0.99999994,-0.021118408,-0.06691703,-0.18306522,0.018065197,0.064213455,0.0055436245,-0.040312093,0.012849065,0.07327746,0.007595786,0.034635123,0.0073958747,-0.07479888,0.011051097,-0.103163436,0.018413119,-0.058288187,0.026428973,-0.036091577,-0.034850597,0.07554469,-0.0067096176,0.019309673,0.045921776,0.052901074,-0.07892129,0.0050554276,-0.096109025,-0.033125013,-0.064883284,0.007393844,-0.066442475,0.09580401,-0.012966387,0.012344394,0.06157391,0.008456711,-0.06742681,0.0255328,0.060075026,-0.057353158,-0.03689045,0.024087723,-0.023466785,-0.010398842,-0.00027762706,-0.0050990377,0.06372802,0.05963783,0.017505866,0.013564905,-0.037138578,-0.071621746,0.025672918,0.071026765,0.019028805,-0.054939553,-0.06554608,-0.011318661,0.09858062,0.063744836,0.0626239,-0.03514906,0.026489547,-0.053101085,-0.034194324,0.06336429,-0.08853976,-0.017447893,-0.056830812,-0.05701617,-0.04314975,-0.022088319,-0.044032294,0.051002424,0.09612927,0.02994776,0.019298017,0.04252468,0.0061368267,0.076354235,0.024082089,0.043077838,0.026824186,-0.037353963,-0.0070315814,-0.021598103,0.032773998,0.069891855,0.024592673,-0.025506748,-0.059557088,-0.027955178,-0.006372783,0.0077987853,0.02601885,0.11313112,-0.013840287,0.069008715,-0.019216944,-0.027711058,-0.0155550325,0.06049015,-0.03870544,-0.062463056,0.068327434,-0.0075582787,0.094241075,0.025729565,-0.009982962,-0.044749293,0.020127233,0.03668774,0.026696304,-0.10636927,0.07727837,-0.015958088,-0.112292945,-0.01903935,0.051324375,0.02120472,0.04913145,0.0942419,0.07014632,0.054864176,0.09746272,-0.011785602,3.0757585e-33,0.07539022,0.10682647,0.06094317,-0.01150515,0.017353944,-0.017391957,-0.038871985,-0.04441886,-0.04978235,0.022495616,-0.050403297,-0.03565264,0.04739824,0.030780667,0.016288992,0.044555176,-0.007899766,-0.07719274,0.023388768,0.026811842,-0.039540954,0.046581827,-0.059183862,-0.026852416,0.020199733,0.05994297,-0.04568172,0.045729835,0.017278159,0.0292748,0.0015152465,-0.07148446,-0.047666166,0.034291543,0.03320869,0.03992156,-0.08157275,-0.072079934,0.046181142,0.044091277,0.017364467,0.028975263,-0.0150500275,-0.011317199,-0.010520895,0.005814379,-0.017296048,0.033538394,0.010412793,0.124220476,0.039070524,-0.011843019,0.055007033,0.040227592,-0.0267029,0.00073253945,-0.08959903,-0.014750069,0.04496164,0.069889545,-0.022021968,0.06388805,-0.025533646,-0.0048745265,-0.018532677,-0.043987077,-0.0683485,-0.054693427,-0.005167514,0.010902099,-0.010131022,-0.101490006,0.036294788,0.01917567,0.05288284,-0.033105563,0.018868344,0.023021298,-0.03340736,-0.05009315,-0.008387363,0.0062996424,0.0028382952,-0.029734362,-0.08616834,-0.0037418315,-0.0035351326,-0.08762887,-0.044219684,0.028689962,-0.04133854,-0.07814097,-0.023161123,0.038157426,0.05998429,-4.6123258e-33,0.10523537,-0.10811784,0.051672224,-0.06432888,-0.017601747,-0.015715534,0.021235943,-0.07864855,0.021332562,-0.031311084,0.023529284,-0.003839569,0.011348744,-0.022155592,0.022368195,-0.044015497,0.01560149,0.049997758,-0.022550821,0.09845676,0.02772115,0.086377025,-0.008482506,0.0032629261,0.024946092,-0.031776052,0.027222112,0.0039150636,0.003341161,0.04715563,-0.012897441,0.03525581,-0.024581311,-0.059119508,-0.028957784,-0.03760104,0.018085599,-0.011908911,0.006346157,-0.015915776,0.013426241,0.097737335,0.043630626,0.0014411802,0.07590794,0.13271658,-0.05257205,0.0032378437,-0.01085865,0.017864652,-0.01697704,-0.009486234,-0.0031119762,0.10654362,0.0073545733,0.043945264,0.044050984,0.028800508,-0.016361145,-0.034185708,-0.045067728,-0.06200679,0.009196951,-0.050565902,0.091317534,-0.0042382604,-0.023103073,0.024850244,0.05082965,0.032132894,-0.026950711,-0.03528219,-0.006443525,0.057618756,-0.015655152,-0.025711777,-0.14297938,-0.09783626,-0.05751657,-0.020356238,0.023380373,-0.016003827,0.042572502,-0.0063643213,-0.024010383,-0.12165373,0.05012373,0.16215518,-0.02630097,-0.0069988566,-0.06545866,-0.042898674,-0.061260823,0.030139044,0.12052832,-4.839863e-08,0.025540931,-0.028036825,-0.006339646,-0.0660162,-0.042466387,0.02340947,-0.014499973,0.024713548,0.041686893,-0.041006498,-0.027659805,0.16526896,0.011332081,-0.04287021,-0.006458044,0.039288368,-0.009386349,-0.025944473,-0.0048971954,0.031912502,-0.08221567,0.007293637,-0.06910203,0.0072652274,-0.031381693,-0.08170461,0.061952014,0.062830545,-0.031925634,-0.05302784,0.03257764,0.05111452,-0.007633867,-0.053913657,-0.10367141,-0.029512482,-0.009572831,-0.0030430842,0.04673095,0.088012144,0.019377843,0.009188965,-0.024770385,-0.009225312,-0.07648549,-0.018121712,-0.019499876,-0.022115443,-0.0056915027,0.051245324,-0.013802535,-0.0324288,-0.10834856,-0.060701426,-0.026337774,-0.057560377,-0.02817634,-0.02340477,0.038165577,-0.033521056,-0.03703334,-0.004506171,0.1655716,-0.066240385 +2.4.1.66,Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.50 procollagen galactosyltransferase).,384,1.0,-0.0076540085,-0.063088804,-0.12218023,0.012977866,-0.0034006215,0.052123915,0.016438626,0.11680792,0.012271025,-0.037709605,0.024476737,-0.09342398,-0.06907249,-0.047920477,-0.09905977,-0.06734082,-0.00012190282,0.0006113817,0.01602593,0.03799217,0.047880735,-0.006335691,-0.021811955,0.071776666,0.076600775,-0.09046756,-0.014335906,-0.06349612,-0.054521605,-0.055461086,-0.012286295,-0.015160424,0.052332416,-0.08575539,0.05286149,0.011473747,0.009332114,-0.055356637,-0.0017386804,-0.022959545,0.0052224137,-0.033268485,0.0196215,-0.0055995346,-0.01524873,0.062626146,0.017147638,0.09865371,0.04410136,-0.033189945,0.0012864006,-0.056474645,-0.051863603,0.008525292,0.036305286,0.08102696,-0.065879256,-0.05598428,-0.019411188,-0.0015361095,-0.01855419,0.061860874,-0.0011867615,-0.04016544,0.04000451,-0.08054458,0.035264704,0.016461048,-0.015985684,0.011243434,-0.058863103,-0.046604425,0.016069395,0.017916525,0.010137878,0.062060855,0.00709271,-0.011586024,0.037924077,-0.022148943,0.030694848,-0.0005650284,0.009416986,0.016833536,-0.06719176,-0.036770195,0.008414147,0.037788346,-0.08248625,-0.009254064,-0.007249872,0.008240766,0.06628162,-0.02787197,0.00013093998,0.040318646,0.08169914,0.007198309,0.13765197,-0.027347028,-0.00249158,0.01642515,0.07782605,-0.010759191,-0.068298586,0.06183377,0.0020179388,0.16325973,0.084774554,-0.07021726,0.033771764,-0.0515135,-0.016109345,-0.041190743,-0.05681129,0.048687104,-0.0019987547,-0.100720026,-0.016865026,0.013736662,0.0051375045,0.0045434735,0.034527466,0.036317118,-0.07777606,0.091952495,0.032528378,1.9738453e-34,0.06322073,0.01925762,0.053360354,0.01082294,-0.042812016,0.013205768,-0.0905035,-0.013687271,0.023324672,-0.010269388,-0.110303834,-0.12695934,0.051020205,0.06514649,-0.047674064,0.01541834,0.0077135703,-0.081538096,0.034894753,0.046185315,-0.062050033,0.082967184,-0.030318482,-0.047071073,0.03254451,0.035452183,-0.061488777,0.0072310846,-0.0030161415,-0.008899066,0.016765203,0.002526231,-0.017446427,0.06831959,0.026634274,-0.04343936,0.064386055,-0.086965635,0.0147712985,0.023545265,0.09998026,0.014494885,0.011613344,-0.02713882,0.056319475,-0.038361058,-0.027221952,0.03669144,0.0054682177,0.09088179,0.06911303,0.011886097,0.00039657712,0.03555369,-0.035557967,0.06645498,-0.0750265,0.046047106,0.033951014,0.05873164,-0.023667017,0.09163196,-0.00024991093,-0.028285468,-0.016707025,0.089750044,-0.06604471,-0.07007209,-0.025883611,-0.040821735,-0.10047369,-0.10775442,0.05840103,0.05815264,0.07172264,-0.014194307,-0.0014272357,0.05431227,-0.05217102,0.00995473,0.020913927,0.16850005,-0.0009558433,0.02870827,0.009519922,-0.027869726,-0.042279344,-0.0743516,-0.009350375,0.06444322,-0.022064142,-0.043996666,-0.04382351,0.05668684,0.0014533916,-1.796556e-33,0.0980692,-0.08825124,-0.05439471,-0.036123432,-0.017642654,0.023444152,0.024090577,-0.08448482,0.03237556,0.010927059,0.09526526,0.01166668,-0.010500502,-0.117409736,-0.023949575,0.0063460255,0.024775384,0.070893325,-0.045672756,-0.00556743,0.0279341,0.05027745,0.08224085,-0.035510343,0.065007895,-0.06088352,-0.027331378,0.02346858,0.02587763,0.01827466,0.032573797,-0.07603359,-0.039091017,-0.025924023,-0.059508316,-0.049237683,-0.055020284,0.033946816,-0.014973215,0.03242338,-0.0302653,0.031792246,0.014953895,0.0012292139,0.096510425,0.082571715,-0.029622395,-0.078048795,0.014953867,-0.0013660497,0.06179705,-0.04826179,-0.005316087,0.051068064,0.031979125,0.05116404,0.1187071,0.086651854,0.08547238,-0.00013203417,-0.002292508,-0.06330734,0.06901579,-0.08139637,0.024271527,-0.0032237142,-0.06522339,0.024147946,0.0908412,-0.029315006,0.078617,-0.048278473,0.025177853,0.08032863,-0.00971317,0.006827766,-0.08330552,-0.08097197,-0.0017633953,-0.0525804,-0.035198413,-0.0176789,0.03775243,-0.056995906,0.07629932,0.007169957,0.0121237915,0.0775473,-0.04471937,0.007882968,-0.05264876,-0.052609973,-0.010121755,0.009504656,0.03687002,-2.9266602e-08,0.09826272,-0.02304099,-0.008164297,-0.06526933,-0.033413503,0.058155097,-0.008517427,-0.012689832,-0.007427268,-0.033281397,-0.010388204,0.043100715,-0.010185999,-0.01809522,-0.03035587,0.005114323,0.038041294,0.038430262,-0.045469802,-0.008729595,-0.05652789,0.0074272435,-0.08204157,-0.00091568293,0.005453309,-0.1381617,0.06292218,0.08370611,0.006319201,-0.027530221,0.048107542,0.044634577,-0.026940173,-0.025178349,0.012658205,0.06588486,-0.010385521,0.03964271,0.012591021,0.021649081,-0.019817369,-0.041782297,-0.0075868857,-0.024956146,0.02739349,0.026821764,-0.011630265,0.091916546,-0.045889523,0.02486842,0.035480965,-0.05446991,-0.090543576,-0.024052013,-0.008245528,-0.048449863,0.017266102,-0.0762363,-0.005259375,-0.061030187,-0.022891892,0.041414242,0.06699819,-0.0543693 +2.4.1.67,"This enzyme also catalyses galactosyl transfer from stachyose to raffinose (shown by labelling) [4]. For synthesis of the substrate, see EC 2.4.1.123, inositol 3-alpha-galactosyltransferase. See also EC 2.4.1.82, galactinol---sucrose galactosyltransferase.",384,1.0,0.005931947,-0.056096017,-0.17819202,0.045429196,0.059621464,0.024504686,-0.018809045,0.03947891,0.017686486,-0.03886628,-0.015787032,0.0018628453,-0.0634168,0.02973931,-0.05683083,0.038991462,-0.049204472,0.049931288,0.023998763,-0.006738716,0.16973308,-0.0371542,-9.370713e-06,0.0737388,0.09929194,-0.06796435,0.001317392,-0.09974944,-0.041584443,-0.11077492,-0.01166448,-0.025837338,0.08884342,-0.067286626,0.013357521,0.08988623,-0.049260024,-0.1041283,0.037858132,-0.052087456,-0.007731853,-0.041145112,0.011343548,-0.023434054,-0.06201474,-0.01726942,0.02863193,0.053210475,0.054571826,-0.0088993935,-0.027064435,-0.10480115,-0.060785796,-0.039130308,0.048467748,0.09432023,-0.02550006,-0.07078353,0.03383057,-0.01037155,0.07172151,0.06719458,-0.017990757,0.015338145,-0.020411685,-0.04755663,0.06443566,-0.04581744,0.01394934,-0.049561523,-0.04361702,-0.060495142,0.026481036,0.029240312,0.029202001,0.04150271,0.025210992,0.05502146,0.08633524,0.01362508,0.050946433,0.01863924,-0.015530179,-0.0032707856,0.016604146,0.05208876,0.015972754,0.032705177,0.048951436,0.025628746,0.011569421,-0.045575153,-0.03869278,-0.00071735284,-0.05973135,0.018469647,0.049622104,-6.0444295e-06,0.08080134,-0.023407323,0.01875,0.030706353,0.034517333,-0.051244076,-0.026431013,0.050438732,0.0054695653,0.03963428,0.007128029,-0.015966443,0.0028780065,-0.026628641,0.052637402,0.009552877,-0.06458728,0.12731417,-0.05106717,-0.074794866,-0.038279638,0.023699941,0.031887103,0.012457363,0.036645178,0.057657324,-0.019612467,0.064279675,-0.0665927,2.6768041e-33,0.0312982,0.08064006,0.015105131,-0.0350543,0.005521046,0.0038445971,-0.06487486,-0.012992712,-0.030734649,-0.036236923,-0.11469688,-0.08692365,0.06093633,0.014932753,0.0049761906,-0.032981295,0.04668148,-0.012601367,0.05519415,0.045697726,-0.062848166,0.044180892,-0.08291621,-0.041499883,0.049813595,0.014300797,-0.032080464,0.0028319736,0.09697223,0.020525746,0.023143165,-0.018820234,-0.098074175,0.018580172,0.05131268,0.0151245985,-0.027552256,-0.097155795,-0.028828435,0.056952804,0.0066880356,0.0055345036,-0.03206893,-0.026572213,0.021049263,-0.0706334,-0.021658365,0.031456262,0.08930799,0.01952295,-0.0041247103,-0.03005555,0.03579664,-0.025927858,-0.027196527,0.04821124,-0.014267121,-0.00021549988,0.08962447,0.057372767,-0.016880445,0.0063350596,-0.018252943,-0.00877719,-0.0070011467,0.021818636,-0.06203127,-0.019490803,-0.03183562,0.015444324,-0.07586996,-0.02162994,0.03578904,0.03814361,-0.006864529,-0.052083697,-0.037725408,-0.0050560953,0.073992394,-0.0054310737,0.017039377,0.021920502,-0.021465093,-0.019195832,0.011029221,0.01706724,-0.03964241,-0.05146028,-0.026830848,0.12405768,-0.0637778,-0.07620166,-0.019801104,0.015107359,0.047978207,-4.0475874e-33,0.106646664,-0.10442356,0.047751665,-0.10700991,-0.06410413,0.07942945,0.05004912,-0.06869418,0.021623466,0.014075623,0.04117297,-0.030390548,0.04026814,-0.09988435,0.003096721,-0.052881632,0.025286155,0.04192615,-0.0384075,-0.0142386425,0.05519963,0.10992202,-0.026197363,0.022916524,-0.016552024,-0.055978633,-0.023028543,0.114979975,0.005006431,0.057969492,0.009734547,-0.07286498,-0.022830063,-0.04714939,-0.04834015,0.0077397865,0.024882829,0.02410702,0.03065478,0.008130812,-0.0122051295,0.08194077,0.025748653,0.035075862,0.055652533,0.08715883,-0.09024034,-0.0008045139,0.075378254,-0.069615096,0.031998146,0.0017180844,-0.061238233,0.032624986,0.021678174,-0.008373107,0.038049236,-0.014943077,0.050351717,-0.04455316,-0.08928192,-0.053605594,0.045251828,-0.08465316,0.10388567,0.012831101,-0.07573242,0.028103866,0.022966934,0.004542072,0.069883816,-0.04638835,-0.032902524,0.12964828,-0.005606854,-0.06458925,-0.07679751,-0.04271471,0.028500654,-0.067924075,0.08496257,-0.03208241,0.040305432,-0.015212404,0.033112478,-0.08110588,0.102506906,0.09850871,-0.009011959,-0.006985706,-0.043659348,-0.006598938,0.015085508,0.000100924255,0.12178065,-3.7396827e-08,0.028246501,-0.026996652,0.013001497,-0.043762445,0.006388794,0.05544172,-0.0042665116,-0.033158045,0.016819134,-0.09635972,-0.0865129,0.08732776,0.02719691,0.015899466,-0.0029877718,0.014712117,0.008836618,0.030208193,0.021444272,-0.007822151,-0.049077645,-0.024229145,-0.060989387,0.00080035836,0.008931465,-0.06363393,0.08817262,0.09035878,0.031211145,-0.0692982,-0.041627076,0.013528631,-0.0074604903,-0.015532419,-0.058494948,0.037507426,-0.030759258,-0.01046576,0.018187605,0.053508993,0.010192441,-0.0408178,0.018202726,-0.018089408,-0.059837464,0.023236794,0.005924104,0.022438219,-0.04166323,0.003536306,0.061927844,-0.06969783,-0.054410245,-0.040514868,-0.032879844,-0.048591536,-0.011076219,-0.061231647,0.018098839,-0.025547933,0.06077194,-0.024981663,0.1515333,-0.023706831 +2.4.1.68,"This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage.",384,1.0,-0.014810827,-0.024465276,-0.13167413,0.053172313,0.08507479,-0.010842074,-0.071927585,0.011810962,0.04498336,-0.0658381,0.07410166,-0.027804373,-0.07030335,-0.011346701,-0.055598777,0.010651852,-0.09712147,-0.004355679,-0.044343654,-0.03865456,0.030944023,-0.014874588,0.0034849218,-0.008380605,0.041830342,-0.098107524,-0.00986318,-0.048684213,-0.002525211,-0.109489314,-0.0054971036,-0.059918582,0.038636763,0.00076215307,0.06683703,0.013235645,-0.03178793,-0.057267353,-0.0080716545,0.046711687,-0.0130349295,-0.04980249,0.009416255,-0.08676961,-0.05625978,-0.014250349,-0.027327701,0.04435348,0.034829125,0.06912501,-0.00071030896,-0.03128963,-0.07170886,-0.010233811,0.037409414,0.03928056,-0.07105377,-0.005424482,-0.016920248,0.11950508,0.045435157,0.06029553,-0.05449191,0.013849212,0.0036218464,-0.07108705,0.084745474,-0.067624904,-0.036336824,-0.019194303,-0.084900096,-0.09076685,-0.01697342,-0.01881769,0.06875744,0.07779937,-0.016731832,0.023287904,0.06483045,-0.01891387,0.07675961,0.020688554,0.02642625,0.030921526,-0.023553599,-0.017585156,-0.04526445,0.013252302,0.039287653,0.047995225,0.03979877,-0.04367555,0.0036279028,0.007613932,0.027767543,0.07657534,0.0076156324,0.057977065,0.06669886,-0.008069945,-0.03377952,0.09739932,-0.008881921,-0.07246244,-0.04591664,0.054971125,0.0056213066,0.1284113,0.035361223,-0.050755303,-0.0086020185,0.0027418605,0.08815261,-0.030287893,-0.02922649,0.03479567,-0.003327039,-0.07597498,0.016101629,0.016263606,0.123910494,0.0158064,0.06188855,0.07994784,-0.030948525,0.032478966,-0.039207198,-1.650438e-34,0.071700536,0.14492173,0.007598613,-0.00631087,-0.018616907,-0.030166866,-0.07344352,-0.041642416,-0.122506216,0.042816505,-0.101836205,-0.02731962,0.008103027,0.059073746,-0.01841939,-0.027755706,0.029745238,-0.004178207,0.007015115,-0.036824856,0.03799109,0.016401542,-0.01301696,-0.058342695,0.053425755,0.11789192,-0.040465545,0.06781531,0.04816346,0.004723991,-0.030863065,-0.06270597,-0.06259051,0.0034660143,0.00433245,0.0032258364,-0.061034247,-0.10564976,-0.0033472385,0.052198958,0.04019553,0.054509748,-0.03188701,-0.052949112,0.032446172,0.008170406,-0.009793253,0.046395257,0.0338022,0.086850315,0.008233923,-0.056188937,0.06067872,-0.049891934,-0.026517767,-0.010321744,-0.050732996,-0.0071672047,0.0033460215,0.074935935,-0.022165226,0.08128133,-0.033078887,0.014043816,-0.026063079,-0.0114613185,-0.031503804,-0.024402063,-0.024314415,0.02872188,-0.044652823,0.00015531402,0.097268514,-0.008259935,0.051157042,-0.092243016,-0.035452876,-0.052317034,-0.012406352,-0.018306943,-0.06881742,-0.021733006,-0.017149461,-0.007640102,-0.008369391,-0.0064916667,-0.06301187,-0.07171198,-0.0050894255,0.053758595,-0.03599128,-0.06709007,-0.025358997,0.09185205,0.028827755,-2.5073688e-33,0.060768213,-0.098578125,0.062397216,-0.095476516,-0.041765895,0.008436968,0.04517336,-0.0053861868,0.012110559,0.043590605,0.047376588,-0.028532276,0.054704964,-0.13053873,0.050339192,-0.03818616,0.011841777,-0.0012136983,-0.008020931,0.032659966,0.052437276,0.026872614,-0.0013095664,0.078118265,0.03301632,0.008652816,0.03759159,0.0402114,0.06482354,0.052061666,-0.033627637,0.005890301,0.021295866,-0.05853355,-0.02031723,0.04204058,0.008963979,-0.005223631,0.053402286,-0.04627195,0.024408154,0.07242713,0.014916567,0.022711016,0.10797128,0.123197205,-0.01469041,-0.021926776,0.01349774,-0.042649213,0.016634442,0.025376659,-0.0379776,0.04519176,-0.0107705565,0.030340692,0.035364438,-0.052014735,-0.06561707,-0.030295352,-0.06930665,-0.10440278,0.010924113,-0.015569009,0.08316857,0.024964226,-0.0010966903,0.020734861,0.063737,0.05665361,0.07155036,-0.052229933,-0.019469246,0.01024848,0.032349017,-0.044127397,-0.11634835,-0.031901777,0.009713132,0.012151499,0.004347864,-0.019064074,0.033924658,-0.048835654,0.06062964,-0.12856103,0.028043423,0.144231,-0.013376357,0.04200711,-0.07660957,-0.027848128,-0.027774777,0.026086131,0.005846472,-3.9844572e-08,0.06901313,-0.05394276,0.02602094,-0.021415109,0.014624671,0.07754923,-0.050103318,0.054245047,-0.02974346,0.024006357,-0.05854598,0.113058746,0.01589941,-0.04821069,8.251164e-05,0.039619394,-0.048365153,0.0228792,0.008193486,-0.001473967,-0.04173732,0.020711595,-0.044784274,0.0137208775,0.014299816,-0.07785045,-0.036294784,0.09817414,-0.042343527,-0.036279254,-0.009801814,0.037739646,-0.05660084,-0.0035703413,-0.11894277,-0.02270802,-0.0104127275,-0.033843517,-0.024556318,0.03971781,0.033001095,0.008208586,-0.05016951,0.0046671364,-0.03151155,0.0043011745,-0.005139716,-0.035496864,-0.016312677,0.0012574691,0.0659727,-0.07877228,-0.06761923,-0.02682794,-0.025636645,-0.056773618,-0.024924783,-0.0054416624,0.061704207,-0.062464606,0.016090395,0.0042096837,0.17720471,-0.051060233 +2.4.1.69,"The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates.",384,0.99999994,-0.033743694,-0.06701409,-0.15384199,0.016450463,0.00841797,0.012669089,-0.027858108,0.069836654,-0.0073057287,-0.0174204,0.061071273,-0.0052657234,-0.1219374,0.09807626,0.026976986,0.026517037,-0.044551905,-0.050592154,0.019662848,-0.093012735,0.060519233,0.010085607,-0.0077893785,-0.055816058,-0.028307594,-0.03704806,0.008384287,-0.016280014,0.019619914,-0.08296327,0.016317053,-0.07738745,0.061574835,-0.004566793,0.039807223,0.008220443,-0.0631526,-0.029493373,0.038900025,-0.025657898,0.041730367,-0.030478803,-0.028153166,-0.023068124,-0.06018127,-0.030547164,0.040198572,0.1058923,0.066360675,-0.0014835265,-0.017880589,0.005913055,-0.026258018,-0.02189379,0.037737988,0.048933063,-0.049029194,-0.02159671,-0.04296835,-0.00086252776,-0.00896701,0.051103618,0.008196422,0.0118728755,-0.0068988213,-0.057384785,0.03692419,-0.096529655,-0.0069684605,-0.027270593,-0.08512727,-0.04908775,-0.031818353,-0.033894736,0.057122823,0.038976606,-0.0046558324,0.02360898,0.025213525,0.007721861,0.016860463,-0.03786236,0.10617717,0.100885525,-0.017422117,-0.025131296,0.016342215,-0.02412584,0.0027257309,0.020777823,0.043400645,-0.04137283,0.053658485,-0.0069969315,-0.054514088,-0.030030975,0.03631226,0.019927634,0.040855285,-0.020095801,-0.041311778,-0.029348763,0.030328726,-0.031857777,-0.053856038,0.06983738,-0.039177395,0.05664068,0.07227899,-0.009407263,-0.051663373,0.071099006,0.048416518,-0.0537757,-0.01386488,0.07520072,0.002801499,0.002708039,0.0013200296,0.018648634,0.01950051,-0.02897221,0.09496113,0.0466255,-0.050945953,0.0075205476,-0.112463474,1.5731125e-33,0.07151733,0.028749974,0.063142434,-0.026212864,-0.05719619,-0.007862784,-0.017798007,-0.070677854,-0.012071472,0.0028698763,-0.008886656,-0.12244093,0.0033232505,0.12826592,-0.02057535,0.018643884,-0.023527196,-0.031694837,0.0040635616,0.025085146,-0.003982567,0.056800522,0.008489413,-0.12536013,0.054472364,0.044297073,-0.03590143,0.059093192,-0.002785525,0.018775841,-0.035572197,-0.10077611,-0.081547864,0.05839027,-0.013182378,0.04709478,-0.055115387,-0.05341686,0.00884885,-0.0069306483,0.014911786,0.014667866,-0.045621876,-0.043685403,0.057945978,-0.017141663,-0.003976227,0.09266945,-0.01485956,0.11329982,0.026019402,-0.027032098,0.08744064,-0.016901765,0.04541807,0.011007792,0.06306681,0.0064263996,0.061052334,0.05185873,0.016169552,0.098436564,-0.009293099,0.033001773,-0.011401749,-0.007452533,-0.023866935,-0.110952176,-0.029309392,0.1108416,-0.028712504,0.01006067,-0.0107292235,-0.002721282,0.009935662,-0.0862476,-0.021438053,0.04977557,0.03857984,0.008847432,-0.01781361,-0.031484812,0.037228845,-0.07930239,-0.107035495,-0.024422133,-0.083933584,-0.10460183,-0.06327666,0.048724018,-0.0006990187,-0.045039654,0.017948857,0.06502224,0.07697377,-3.938753e-33,0.020815898,-0.05117714,0.051842757,-0.04814506,-0.08548403,0.038661923,0.036573924,0.027485987,0.016926037,0.06308116,0.019553063,0.017640438,0.042542037,-0.0764761,0.02318887,-0.0080203675,0.0005434086,0.112088755,-0.058954682,0.013359723,-0.031365484,0.074076846,0.046400003,0.024946673,-0.039288327,-0.0004798939,0.02251274,0.044350076,0.022940286,-0.0077169063,-0.046494793,0.10094844,-0.033536263,-0.05696616,0.006001404,-0.06784116,-0.10188801,0.0027571889,0.062781684,-0.04666546,0.021700013,0.13261136,0.05806522,0.06361884,-0.011570511,0.06457687,0.0031932546,-0.028226981,0.034408234,-0.028552521,-0.0722227,0.023579445,0.0182705,0.035592847,0.038114347,0.09457006,0.03283912,-0.03818538,-0.071009085,0.027109869,-0.05063728,-0.08372204,0.027067741,0.001609293,0.0561062,-0.03087311,-0.024649411,0.039331313,0.06298808,0.043959342,0.050675318,0.002050016,0.02651814,0.0010258446,-0.04049527,0.0010870721,-0.12051849,0.013008549,0.05222763,0.04398572,0.053861823,-0.012145756,0.0058747837,-0.060002055,0.07016831,-0.12238445,0.019165559,0.09741361,0.032900933,0.056427795,0.00599731,-0.017992903,-0.02732319,0.032420292,0.044051964,-4.4438174e-08,0.028690824,-0.11717016,0.06478148,-0.047632094,-0.049973086,0.06904619,-0.07598923,-0.0951129,0.018569626,0.043005683,-0.09119701,0.08866702,-0.0015156451,-0.033444446,0.05501252,0.07159268,-0.06134619,-0.017741244,-0.006386029,-0.0050292965,-0.05984897,-0.07591402,-0.060031332,0.06526784,0.0028765139,-0.07902264,0.0002411949,0.063623615,-0.030366862,0.009077969,-0.040695902,0.049131896,-0.08666975,0.032854702,-0.07530681,-0.04705625,0.026086586,-0.034889836,-0.015582079,0.033602394,0.05319562,0.00814136,-0.02950652,0.011685117,0.012192075,0.051377457,-0.031352885,-0.00011840516,-0.09906724,-0.029650051,-0.00454439,-0.0058916993,-0.03801953,-0.039988507,-0.07761612,0.059344824,-0.035166953,0.008669312,-0.0015295111,-0.04191575,-0.0013552615,0.035202965,0.13795434,-0.019688705 +2.4.1.70,Involved in the biosynthesis of poly(ribitol phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-alpha-D-glucosamine to the hydroxyl group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.355 [poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase].,384,1.0,0.013836864,-0.070598304,-0.125138,-0.06873091,-0.049838226,0.06883465,-0.08208959,0.03780139,0.08028339,0.021393985,0.00022911058,0.0023467916,0.0062590735,0.031120662,-0.09659829,-0.053017374,-0.061015505,-0.0038926695,0.02851002,-0.03383139,0.0688043,0.049151152,-0.050942153,-0.038470306,0.040398292,0.052760854,0.034557015,-0.051967878,-0.016387906,-0.03576024,-0.03741005,-0.03711434,0.109096,-0.05673243,0.05273764,0.09614355,-0.020880038,0.001308765,0.078430176,0.023305358,-0.0091646705,0.0087467665,0.058869816,-0.0013870314,-0.00630086,0.0015902154,0.011681195,0.06801911,0.056849748,-0.014238487,-0.0065572234,0.016028222,-0.053679515,-0.024287399,0.008919095,0.032699477,0.021754002,-0.05398173,-0.008658168,0.00024381802,0.05734497,-0.042669162,0.030012326,0.007722246,0.0122681195,-0.04084859,0.056811403,-0.042480502,0.0041150423,0.0041785245,-0.05515259,0.08363615,0.025383215,-0.014577636,-0.027234323,0.0054489425,-0.020554883,-0.04877426,0.0038217402,0.017697943,0.011129819,-0.014832421,-0.05738396,0.11505454,0.024469072,0.048195705,-0.03250459,-0.0059977123,0.036162492,0.08923402,0.026543487,-0.0032878355,0.046896804,-0.062384482,-0.026407056,-0.01783247,-0.014194369,-0.012209166,0.017834803,-0.07555504,-0.06310937,0.016270967,0.035278708,-0.05734467,0.006837665,-0.014581337,-0.04552125,0.08703856,-0.008134318,0.045375794,0.020474698,0.04919787,-0.039711095,-0.022492195,-0.058544304,0.07539476,0.0690005,-0.13591567,-0.07103561,-0.05916174,-0.01629987,-0.077649385,0.037287217,0.048539203,-0.03542919,-0.049151987,-0.015428902,1.2497033e-33,0.047883224,0.049631197,0.038917206,-0.052157942,0.019158626,0.004760119,-0.061888326,-0.082009204,0.016273955,-0.023759581,-0.13707139,-0.046759907,0.08149347,0.010154576,0.05799885,0.04635281,-0.015839955,0.016306745,0.044121075,-0.0038278294,0.0128671015,0.10722103,-0.005199766,0.028949093,-0.027618952,0.029240655,0.014896349,-0.024140675,-0.012044815,-0.007989296,-0.0073366454,-0.027434578,-0.04935034,0.044465095,0.123006135,0.016722633,-0.09432139,-0.022980746,0.11379889,0.035667993,0.06830826,0.039072808,0.057219397,0.009584146,0.038196605,-0.018470593,0.026116544,0.016045893,-0.027140899,0.08098171,0.053838234,0.028655704,0.026643775,-0.008227037,-0.07298283,-0.0059500397,-0.04535749,-0.013507937,-0.005043108,0.11686303,0.024336234,-0.0011999054,-0.04524575,0.038908787,-0.071899086,-0.045465,0.018792432,-0.034906708,0.031740468,-0.0063544963,0.01563184,-0.083314806,0.044162963,0.028219273,-0.04524089,0.042274166,-0.02808542,0.016773744,0.050265905,-0.061190557,-0.01596679,0.03079672,-0.030573225,-0.07629388,-0.05293477,0.07139382,0.07233809,-0.059757765,-0.0019053696,0.021757172,0.013618662,-0.121227175,-0.05764099,0.07396421,-0.0013519555,-3.7692667e-33,0.08309235,-0.20095482,0.07516577,-0.118462525,-0.073569134,0.04740285,0.019488586,-0.03096388,-0.011877005,0.013684135,0.0747756,0.051306996,0.012733584,0.024222689,-0.007507562,-0.03492235,0.05428537,0.08348468,-0.06730158,-0.04343504,0.006534534,0.020712582,0.042366922,0.0007266644,0.009718517,0.053647798,0.012530797,0.0055131325,-0.008499408,0.03917344,-0.024800774,-0.011509628,-0.060129493,0.033851564,-0.04978756,0.010330173,-0.00066948327,0.013502913,0.075365335,-0.011340985,0.02691265,0.061752774,0.032592822,-5.7319114e-05,0.047219794,0.07197833,-0.05046299,-0.03137368,-0.06808098,-0.06683952,0.050970852,0.043393243,0.05679722,0.04734582,-0.0027586147,0.047217637,0.0069526345,0.026505003,-0.0044340584,-0.039168816,-0.056132495,-0.064105816,0.010220676,-0.03483167,0.021711105,0.006463438,0.033903055,0.003943506,-0.008662988,-0.04803171,-0.010218571,0.03089728,-0.01286766,0.064332254,-0.04130715,-0.12420907,-0.11277197,-0.07127931,-0.005076561,0.003627476,-0.034180656,0.017113531,-0.01298704,-0.012500688,0.02015742,-0.08784501,0.099875264,0.093003586,-0.018817525,0.055556737,-0.030569097,0.043462295,-0.07983198,0.03832231,0.08967476,-4.2132246e-08,0.04775971,0.018561661,0.04845487,-0.055443875,-0.050426785,-0.015657993,-0.048311077,0.009568211,0.082195,-0.04715704,-0.035274636,0.049270865,-0.032688346,0.0077695237,-0.070918344,0.07309683,-0.11307724,-0.09798116,0.020185322,-0.0848917,-0.06720038,0.017606085,-0.057048667,0.023482457,-0.037006017,-0.005287549,-0.011073035,-0.037693918,0.0068133324,-0.027605705,0.020958101,-0.005546328,-0.0029122618,-0.09548062,-0.050719768,0.034291703,0.085549295,-0.09148241,0.06525785,0.048376556,0.0030511003,-0.025995659,-0.05235528,0.042103715,0.00815805,0.038068816,-0.038334504,0.039173543,-0.036813766,0.01491642,0.069375105,0.031580493,-0.06964498,-0.04758623,-0.109400764,-0.0043584364,-0.062102187,-0.1153608,0.033653304,0.084661275,0.015857002,0.007387009,0.10717214,-0.018096332 +2.4.1.73,"Transfers glucosyl residues to the D-galactosyl-D-glucosyl side-chains in the partially completed core of lipopolysaccharides. cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase), EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase) and EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I).",384,1.0,-0.032773737,-0.11659502,-0.05161493,-0.017811574,4.5452103e-05,0.002174603,-0.031104932,0.018984938,0.026435908,-0.00057598087,0.06284783,0.042534232,-0.01799318,-0.038554106,-0.062039994,-0.05456954,-0.045399714,0.011448231,-0.029863494,0.051306885,0.0881074,0.018812157,-0.048817076,0.04237322,0.058206595,-0.033471644,0.016130293,-0.087992184,-0.039930027,-0.06386522,-0.04728347,-0.07695639,0.025573855,-0.05864335,0.06584694,-0.009136848,0.014245697,0.020209447,0.08349396,-0.046201594,-0.0050761923,-0.0120489905,0.0669651,-0.0011655472,-0.023049869,0.00069235,-0.036145136,0.05606286,0.04092211,0.05229177,0.07606437,-0.07612859,-0.08712515,0.0058635264,0.032667715,0.06202773,-0.0040248684,-0.035940114,-0.0054668654,0.08197769,-0.004930685,0.01505552,0.012126935,0.0041567357,-0.06344689,-0.08856786,0.1523308,-0.04205534,-0.0003119052,-0.018723905,-0.083359286,-0.045694973,-0.028519142,0.008331888,0.06434064,0.059157703,0.013373039,0.0029219214,0.05094869,-0.07334782,0.07843886,0.014650564,0.051446803,0.071537696,-0.032381613,-0.054805633,-0.0099932505,0.027559768,0.004378,0.02128545,0.009160666,-0.08935297,0.033793714,-0.0076550115,-0.023248686,0.050052196,0.021468297,0.03741439,0.07929638,-0.06991862,0.00021511916,-0.03541159,0.029281836,-0.06171954,-0.05430714,0.07143716,-0.022207657,0.025780387,0.013853392,-0.007865736,0.011808812,0.009970067,0.060511842,-0.052138053,-0.09948355,-0.0028541384,0.020158058,-0.067917235,-0.07601224,-0.02195819,0.0074294354,-0.028142396,0.13155194,0.0377827,-0.031657502,0.069442526,0.03597449,4.2846758e-33,0.0014287137,0.005704762,0.049793996,-0.030505462,-0.02639024,-0.048834678,-0.094741076,-0.07298697,-0.049770955,0.008504392,-0.04952179,-0.08470927,-0.014823952,0.04322691,-0.03941452,0.13594772,0.08065895,-0.04415385,0.021835007,0.022484936,-0.013122627,0.078785054,-0.005972291,-0.01781499,0.098437764,0.06363139,-0.06191667,0.025613192,0.006450216,-0.010993657,-0.03058554,-0.033095613,-0.036204778,0.056139775,0.093259394,0.04821801,0.03179305,-0.048354823,0.051882282,0.005047632,0.048792735,0.030922754,-0.040510133,-0.055182125,0.01642387,0.02866413,0.0037385577,-0.01960256,-0.008109449,0.073359616,-0.0019181207,-0.027686821,0.059823606,0.08261907,-0.035364535,-0.012666141,-0.051104426,-0.05389599,0.06485898,0.08546966,-0.019287454,0.10142472,-0.03320921,-0.038166624,-0.009105308,0.008812282,-0.09657981,0.015690036,-0.046579253,0.030500801,0.014631572,-0.0932734,0.009952615,0.05602216,0.079633996,-0.04953223,-0.054051593,0.07113889,0.02890678,0.00517518,0.030687844,0.120375104,0.013240763,-0.054136965,-0.021946698,0.02309918,-0.04752408,-0.03971489,0.0053088157,0.045746535,-0.094340675,-0.0135120405,0.015836837,0.083146356,-0.027103065,-6.562723e-33,0.054605324,-0.06493236,0.056825373,-0.07409325,-0.010822949,0.066755064,0.024148477,0.011167242,0.050248507,0.0017268768,0.03274732,-0.0196117,-0.056936927,-0.0369207,0.053347867,-0.00800416,-0.04549471,0.07254245,-0.06195394,-0.03924626,0.04002805,-0.021130277,0.01094709,0.05763568,0.04686604,-0.059497993,-0.04794363,0.08209126,0.014609823,0.066092186,-0.02895055,-0.036980506,-0.03595139,-0.031832654,-0.028458638,-0.0054411353,-0.062071223,0.061111912,-0.05072029,0.026383951,-0.007076565,0.084904745,0.065191284,-0.00197989,0.082548164,0.06692341,-0.06503696,-0.0014926915,-0.022423731,-0.07184454,0.040818874,-0.006716004,0.035821106,0.074324876,0.025534794,0.085002646,0.114866644,0.12610653,0.038459472,-0.04255955,-0.09355488,-0.037744492,-0.018298328,-0.08162542,0.08803034,0.027486594,0.012624945,-0.026939437,-0.011547449,-0.02755751,-0.024566587,-0.018133676,-0.002687573,0.035852697,0.06770532,-0.027405446,-0.14597225,-0.08927328,-0.0022187987,0.00680374,0.08198607,-0.018780146,0.028114153,0.02374882,0.024615208,-0.04894484,-0.0029557706,0.041231867,-0.010140024,0.015748253,-0.0370901,-0.0011957479,-0.013429955,-0.0037793154,0.031323534,-4.4041705e-08,0.04609025,0.0026618761,0.008854334,-0.10446057,-0.018860143,0.0022419107,-0.033734825,0.023878982,0.032761343,-0.016731672,0.028467154,0.1075417,0.0018029214,0.030398848,-0.08314532,0.0084055485,-0.00870694,3.7873546e-05,0.005501196,0.040263392,-0.071158886,-0.004836643,-0.08786175,-0.015167359,-0.021986961,-0.09811306,0.099047974,0.03255621,-0.047089484,-0.030708428,0.010946572,-0.01669714,-0.07808721,-0.03995865,-0.006238469,-0.005571695,-0.024580037,-0.03935988,0.052082192,0.083140284,-0.040931895,-0.050954707,0.035133157,0.008032051,-0.020731596,-0.027334705,-0.045813408,0.034057647,-0.04772911,0.07357026,-0.014119466,-0.07533425,-0.10716518,-0.09396998,-0.028024461,-0.10754685,0.023416283,-0.01463945,0.048334263,-0.045600485,-0.022152131,-0.022366643,0.12811145,0.0032755532 +2.4.1.74,Involved in the biosynthesis of galactose-containing glycosaminoglycan of the ameboid protozoan Dictyostelium discoideum. 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+2.4.1.78,"Ficaprenyl phosphate is the best substrate; other polyprenols can also act as substrates, but more slowly.",384,1.0,-0.007107204,-0.09996227,0.029171225,-0.047883637,0.058510486,-0.006195013,0.0042054993,0.09179881,0.010324353,0.0038605202,0.0013288811,0.031630155,-0.10528609,0.13498402,-0.014820742,-0.020504763,0.04894997,0.04515212,0.11588509,0.037161868,0.09594187,-0.1146498,-0.0044425027,-0.022586998,0.0035548233,0.045615952,-0.022781512,0.003880237,0.04175974,-0.04676543,-0.101016946,0.03046085,0.015354682,-0.050426524,-0.041269127,0.06566432,-0.09320191,-0.015814751,0.0029734373,-0.03762154,0.07053081,-0.076402955,0.035663515,-0.017856251,0.0040923343,-0.025030755,0.016718306,0.033228558,0.031851627,-0.027111806,-0.033105228,-0.046903938,0.03317093,-0.029364407,-0.027570706,0.02559548,-0.08056313,-0.019056672,-0.031671476,0.0029382925,0.00042064238,0.023735803,-0.043487765,-0.016204994,0.07058588,0.08174267,0.0052748243,0.04260524,-0.0033515694,0.10668366,-0.054968074,0.07191742,-0.013620392,0.03647883,0.035134267,-0.0040854383,0.023974776,-0.093035504,-0.0248563,0.052654568,0.013987618,0.07807401,-0.026020829,0.04090126,0.070929565,0.034069773,0.027173642,-0.012401188,-0.07750976,0.012247398,-0.03155204,0.09934837,0.0049072998,0.018004023,-0.012734704,0.05116244,-0.04457551,0.0075596687,0.032611307,-0.029323984,-0.01725536,0.027402893,-0.017897109,-0.04012477,-0.035094637,-0.054865375,-0.030417759,-0.0050390093,0.010433864,0.034511723,-0.031600915,0.04058873,-0.05573139,0.009548505,-0.08011096,0.030244473,-0.0013638983,-0.009591729,-0.002576169,0.015380336,-0.06553272,0.00083250535,-0.006599561,0.044687558,-0.030887088,-0.0079256175,-0.027611097,1.5448918e-33,0.011352238,-0.010263066,0.0059236693,-0.04734702,-0.05422487,-0.0055582495,0.034139607,-0.032654576,-0.057116136,-0.044064667,-0.040543377,-0.05527241,-0.050455622,0.059198737,0.09978049,-0.118263885,0.007768421,0.080969065,0.063942656,-0.025739456,0.02091639,0.0070440616,-0.026592532,-0.043605946,0.058626074,-0.050848775,-0.04481123,0.028657902,-0.03633416,0.0022858083,0.041789614,-0.019398615,-0.00068557955,0.016418193,0.01877297,-0.071669996,-0.1260684,-0.060885746,0.008938846,-0.0087113995,0.018063297,0.08877535,0.08307642,0.022614682,0.03547141,-0.060894262,-0.051968083,0.10674444,-0.031849906,0.0485578,0.050416753,0.03216951,-0.044227522,-0.038056254,-0.021480327,-0.0044304673,-0.0128513295,-0.07181389,-0.04469078,0.054091975,-0.04766235,0.045355212,-0.048411354,0.015677338,-0.0038152726,0.06697098,0.0031922667,0.003386681,-0.032274835,0.006075835,0.057819873,-0.03070669,0.0016211267,0.046341833,0.028369164,-0.02908533,0.0035856906,-0.0085633695,0.041597538,0.010692699,0.034205075,-0.05236898,-0.07939462,-0.045421433,-0.11016065,-0.0043260534,0.07154802,-0.04533121,0.08798819,0.024589233,-0.00012457742,-0.10633197,-0.00062757166,0.0036239577,-0.07701335,-2.7250141e-33,0.11945693,-0.122172095,0.094566114,0.04467108,-0.07590241,-0.0035568175,0.0394713,-0.090598255,0.045845963,0.065857604,-0.01761813,0.026116595,0.013450182,-0.006066501,-0.07940706,0.09775631,-0.0066138147,-0.02527963,0.04659264,-0.054235417,-0.023282697,0.12000875,0.094309315,0.10951624,0.048989434,-0.03752465,0.010549193,0.053707507,-0.09282734,0.037053403,-0.08030341,-0.002407458,0.03396956,-0.055617265,-0.023591446,0.013222914,-0.047734343,-0.057548765,0.03570195,-0.023044124,0.018314498,0.045236826,0.04688775,-0.00078838994,-0.100487374,0.0025258726,-0.0819924,-0.05149561,0.03270012,-0.01216407,-0.021019382,0.030071642,-0.031293634,-0.024630183,0.004831918,0.037689492,-0.008859826,0.00011522777,-0.055838596,-0.053229555,0.0044489074,-0.061296582,-0.0029017061,-0.0755413,0.10467965,0.06722182,0.015074583,0.055895068,-0.024507849,-0.017191654,0.096307665,0.02886767,0.07147652,0.06048129,-0.082148805,-0.06122855,-0.0017705493,0.03259494,-0.037665345,0.037956547,0.0337852,0.011414272,-0.119969994,-0.013243462,-0.008877854,-0.0070552574,0.06133629,-0.02408433,-0.05805824,0.07486339,0.019234464,-0.004576221,0.03661179,0.059303917,0.07805483,-2.6215009e-08,0.042267274,-0.01391792,0.06378268,-0.020757634,-0.10315185,0.008102085,0.01794113,-0.028178701,0.03394547,-0.06008293,-0.061882112,0.051952768,0.037307583,0.030860802,0.089141466,-0.05534989,-0.028069986,-0.031704515,-0.070775814,-0.07262512,-0.104637936,0.019460075,-0.03899458,-0.0011943139,-0.0216351,-0.0094992025,0.12049453,-0.005758735,0.026138565,0.005406179,-0.037136886,-0.016747026,-0.020628234,0.015065064,0.017862745,0.12652048,-0.020178828,-0.04484987,-0.07210343,0.12170506,-0.020167274,-0.0627245,-0.007952481,0.03071593,0.014771864,-0.025245365,-0.038054433,0.058785956,-0.007367489,0.051923018,0.05873196,-0.02449032,-0.055315834,-0.038212962,-0.021713702,0.010730212,-0.026106246,0.009377848,-0.008956482,0.035001192,0.025385981,0.017672095,0.16908485,0.044262152 +2.4.1.79,"Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}.",384,1.0,-0.083950974,-0.10288287,-0.08975953,-0.0638187,-0.0025796636,-0.051101904,0.031240663,0.07947944,-0.019822612,0.047882635,0.037754603,0.061929192,-0.08520513,0.011041225,-0.038790815,0.015405547,0.057466216,-0.054623835,-0.018925231,-0.016349187,0.10370998,0.0035984237,0.019023124,0.0239514,0.023295684,-0.008705111,0.037459657,-0.06711403,-0.013604777,-0.023383351,-0.0234043,-0.040855214,0.052115925,-0.045344748,-0.00085735833,0.09807244,-0.062408447,0.020942848,-0.019326659,-0.046670932,0.010331961,-0.072903,-0.004800463,0.012962322,-0.013256311,-0.023340425,-0.062261097,0.06868622,0.009218133,0.019965598,0.015781943,-0.10525216,-0.057573736,0.03652168,0.029826876,-0.013776266,-0.12801684,0.003387194,0.03144274,0.023350943,-0.059377003,0.07398816,-0.002412567,-0.015143125,0.038324557,0.0075635435,0.06347926,-0.09662996,-0.048752435,0.04277928,0.039634906,-0.05925277,-0.0026271953,-0.021554744,-0.0017505367,0.083520465,0.0026902445,0.018334884,0.047688425,-0.029489858,0.03492966,-0.021035302,0.10717088,0.105708584,-0.010928916,0.017368354,-0.040511552,0.067370996,-0.013644946,-0.04133688,0.033803627,0.007858511,-0.03029095,0.06286036,-0.06939003,0.025246868,-0.034838133,-0.009576031,0.0491365,-0.018089583,-0.0025704945,0.03592283,0.0012832299,-0.041849118,-0.055846885,0.06522341,0.007908033,0.018755699,0.018873982,0.014737225,-0.059759434,0.060427144,-0.024088591,0.025981808,-0.10946128,0.050231338,0.03852522,-0.045896918,-0.04068847,0.00098499,0.031239128,0.03045553,0.058827188,-0.0028148997,-0.01589303,0.084547095,-0.010435778,2.3711769e-33,0.066035666,-0.0021307697,0.043685503,-0.024733046,-0.041280407,0.03248223,-0.03655347,-0.07502879,-0.007367723,0.0356493,-0.025654284,-0.08038971,0.027594596,0.114162065,-0.027510311,0.11870725,-0.019285718,-0.053124107,0.091595866,-0.017263629,-0.01337986,0.07244773,-0.006375894,-0.048306108,0.04667252,0.11878412,-0.048064332,0.06289877,0.086866215,0.008077994,0.043916892,-0.09091546,-0.059607632,0.027294297,-0.009299473,0.051217794,-0.06351423,-0.10588736,0.009368165,0.04563375,-0.007278568,-0.017058797,0.0058863936,0.008426346,0.07797515,0.044114564,-0.03617335,-0.054473776,-0.03740876,0.04273291,0.040676173,-0.02708898,0.00970792,0.06226108,-0.02973283,0.0392406,-0.021713214,0.06375162,0.048023447,0.06776163,0.025785051,0.09917109,0.05417699,-0.023852127,-0.00096738094,-0.009799729,-0.08613507,-0.0151164215,-0.10235932,-0.017310303,0.036746148,-0.08840194,0.07753295,0.068957224,-0.012565369,-0.04031275,0.072706126,0.013796443,-0.025276223,-0.023941772,-0.03788276,-0.026296498,-0.006201985,0.014885909,-0.07354102,0.050690383,-0.031111589,-0.15762098,-0.03308319,-0.010709098,0.019495018,-0.006965793,-0.07677003,0.04166571,-0.040138874,-4.7316682e-33,0.06378674,-0.049400542,0.09230061,-0.03261527,-0.0012436553,-0.021889528,0.08180993,-0.088010654,0.068909526,-0.0062764115,0.021338709,0.04704808,-0.0030295635,-0.04848784,0.027257178,0.013014944,-0.05412532,-0.012497724,-0.030887231,-0.00052594405,0.039501607,0.12945387,0.017944498,0.047992047,0.054620884,-0.0011823572,0.0017408378,0.04633555,0.03667769,-0.002716153,0.022988494,0.054777004,-0.08562944,-0.12679854,0.008070907,-0.0008035982,-0.020433381,-0.038942154,-0.0032163458,-0.028847631,-0.066710785,0.08731551,0.052258283,-0.024381733,0.06060814,0.13743411,-0.015754046,-0.005994388,0.019661086,-0.06928106,-0.025927164,0.0017791635,-0.011914061,0.085284114,0.07121332,0.015228467,0.085490525,0.00041249723,0.0012162847,-0.023062158,-0.005070482,-0.045432456,0.022841053,-0.02739778,0.058420207,0.073247105,0.068856716,-0.037568428,0.036412213,0.050175074,0.0004469848,-0.09523657,-0.04679709,0.036969054,-0.043044724,0.055776782,-0.108364396,-0.010384358,0.016248904,-0.06356641,0.04889808,0.016956542,0.0069377697,0.06690437,0.024752768,-0.10440681,0.024434855,0.10307479,0.007850603,-0.011335743,-0.04270434,-0.013349454,-0.019476093,0.045589443,0.04243147,-4.581466e-08,0.06986793,-0.009273083,-0.03721229,-0.13310227,-0.039121218,-0.040307507,-0.08200295,0.024039315,0.043523256,0.009371627,-0.05713215,0.05898893,0.011879627,-0.028637355,-0.022143254,0.0078107924,-0.031277742,-0.021610849,-0.034775954,-0.073433824,-0.09596813,0.0066370512,-0.10377296,-0.04818582,-0.0050444975,-0.049274623,0.085662924,0.028279297,-0.021979973,-0.050182227,-0.016320188,0.09766336,0.03562189,-0.004205735,0.011313152,0.038499292,-0.027678106,0.017894337,0.030391097,0.012179941,-0.035803646,-0.049600504,0.0001622672,-0.015226568,-0.03277,-0.010227647,0.007595985,0.017445065,-0.06275154,0.028203938,-0.024194904,-0.059938878,-0.071014225,-0.043433733,-0.04651704,-0.045194373,-0.09035359,-0.015269682,0.053224105,-0.08390053,-0.038926814,-0.054983314,0.051564924,-0.036174316 +2.4.1.80,Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor.,384,1.0,-0.08897207,-0.023037152,-0.07442229,0.006712919,0.042970933,-0.024946215,0.05525388,0.023440363,0.02357619,0.012359016,0.034637358,0.010109952,-0.12956345,0.088935696,0.005810689,0.04696325,-0.057378672,0.04364239,0.061737258,0.03908883,0.049908865,-0.06549545,0.010333218,-0.008908337,0.03131793,-0.00691334,0.024130613,-0.001700577,-0.025129534,-0.00064974814,-0.07662739,0.013305524,-0.013552974,0.019021632,-0.0022974776,0.16775429,-0.064808436,0.04435109,-0.023739569,-0.029657288,0.034372244,-0.06656484,0.04456245,0.042698197,-0.0501771,-0.044335596,-0.052987237,0.0807659,-0.015537339,0.0028974772,-0.011802012,0.0225934,-0.016934244,0.08712754,-0.013205809,0.10708556,-0.10473451,0.050303202,-0.037590463,-0.07672886,-0.033614356,-0.010010373,-0.05247534,-0.004877039,0.013869681,-0.046841364,0.046361174,-0.03555196,-0.021882111,0.017108124,0.08124781,-0.029492952,0.06204247,0.0103007,0.11223952,0.06325828,-0.044452485,0.0084242495,0.030276803,0.022337496,0.05435639,0.05618913,0.077125505,0.01562823,0.017760294,0.033838138,-0.03505895,0.058074247,-0.0752177,-0.004517488,-0.04400061,-0.013078112,0.00049511675,-0.010272199,-0.087275416,0.018129842,-0.008903511,-0.016394751,0.043025296,-0.020631826,-0.019728707,0.08167891,0.020657381,-0.066044815,-0.04454175,0.025095863,0.013108744,-0.019377653,0.03569535,0.04970827,-0.0008622226,0.015401119,0.11776418,0.012948824,-0.05375596,0.06969422,-0.089919895,-0.07423127,-0.024845477,-0.05339026,-0.059309687,-0.020979533,-0.026222596,-0.02892697,-0.036265206,0.08388622,0.009248645,1.3141536e-33,0.020722134,-0.04643336,0.040172517,0.02098866,-0.06260842,0.02171599,0.01550881,-0.043099623,-0.041052695,-0.014229219,-0.12877652,-0.08646923,0.03249318,0.09672049,-0.067488685,0.021369971,-0.04983298,-0.005636819,0.10730885,0.025552632,0.050028354,0.096520476,-0.056551807,-0.008473273,0.054987155,0.008561333,-0.118595876,0.0140133975,0.09565515,-0.026059758,0.06455665,0.006163267,-0.020698119,0.010197006,-0.023685295,0.015749758,0.0023201911,-0.003501777,-0.0028919426,-0.03874765,-0.02038887,0.009965447,-0.012240151,0.01947075,0.03567616,0.012718218,-0.016182749,-0.12819818,-0.041777108,0.05997359,0.01925519,-0.07160207,-0.013515444,-0.0071816193,-0.013426026,-0.05414626,0.026352977,-0.010020706,-0.007247526,0.028630784,-0.0098825805,0.07565121,0.036336724,-0.02216679,-0.026514912,-0.03300505,-0.04771063,-0.064438626,-0.12211209,-0.016140195,-0.04044467,-0.018961921,-0.033228334,-0.030123146,-0.0229035,-0.050296403,0.01899076,-0.042947557,7.624708e-05,-0.009294702,0.00021386742,-0.10995977,-0.025562841,0.023669727,-0.08798694,0.0077465144,-0.030049982,-0.1116065,-0.0042890823,-0.07326396,-0.012574317,-0.011662281,-0.097511716,-0.043808147,0.06022791,-3.874932e-33,0.04760668,-0.08857832,0.07558338,-0.041968968,-0.0035060227,0.06553534,0.043862555,-0.12872894,0.119222656,-0.007882174,0.0037525203,0.011014721,-0.0220755,-0.0066526937,-0.022671746,0.035469018,-0.10569493,0.031729832,-0.03719286,0.018633666,-0.04651098,0.1815711,-0.011662181,0.05713738,0.028602948,0.018477293,0.0044519226,0.04227972,0.07736588,0.0044360487,0.009410862,-0.030652469,-0.035821564,-0.029350238,0.03790643,-0.014994171,-0.011727035,0.0013174621,-0.06396342,-0.041213088,0.000488399,0.017556205,-0.01271223,0.12018851,0.08711857,0.037287176,-0.007354588,0.014650069,-0.0070226714,-0.021883177,-0.02771718,0.029149964,-0.023845721,0.028079452,0.08212055,0.05616452,0.032128625,-0.06610326,0.005273016,-0.09422621,-0.06865873,-0.053616527,0.003521193,0.033997457,0.02975585,0.01378607,0.01994367,0.065675944,0.044375945,0.003641109,0.019951278,-0.018218819,-0.029392662,0.068895385,0.022253633,-0.057046022,-0.064489186,-0.002583844,0.0076304446,-0.034108378,-0.031080354,0.01892679,0.057402585,-0.006521853,0.07419018,-0.019763736,0.046134192,-0.053828377,-0.07078433,0.06276853,0.017593112,0.04373401,0.056133747,0.019322926,0.033206616,-2.7253565e-08,0.06288593,-0.01345331,-0.0013756575,-0.07480386,-0.072583765,-0.058732964,0.0036694617,0.039635535,0.0047780606,0.019520074,-0.06262082,0.11892241,0.030052869,0.03622832,0.08976053,0.011669417,-0.017548092,-0.030077,-0.075422026,-0.039403535,-0.10464259,-0.04452459,-0.09351393,0.06022076,0.041198216,0.012025678,0.0536381,0.015635485,-0.004777039,0.014648993,0.028009703,-0.0060443296,0.008081001,0.0486866,0.098315254,0.035582572,0.016009822,-0.011483548,-0.04783432,-0.015652575,0.015746973,-0.08591087,-0.051470526,0.009991038,-0.034089647,0.012295176,0.032359507,-0.042010944,0.057739984,0.07053143,0.012973818,-0.04250466,-0.029219773,-0.032772183,-0.075185925,0.009882988,-0.084402636,0.10189603,0.10232016,-0.07094058,0.006435245,0.03567192,0.09738079,-0.028473226 +2.4.1.81,"A number of flavones, flavanones and flavonols can function as acceptors. Different from EC 2.4.1.91 (flavonol 3-O-glucosyltransferase).",384,1.0000001,-0.062246058,-0.09889189,-0.08528898,0.045674983,0.0525517,0.030508228,-0.030337673,-0.01859634,0.08616544,-0.10879317,0.06261038,0.0033396063,-0.082720906,-0.042419527,-0.04050376,0.0076426673,0.0013329509,0.057187203,-0.09680288,0.010156792,-0.018849473,-0.044962097,0.034152597,-0.034694202,-0.016708815,-0.029338915,-0.019204095,-0.053733658,0.016617011,-0.120426565,0.04527537,0.0021804762,0.07061357,-0.020809492,-0.08011548,-0.0264751,-0.021544065,-0.054780617,0.00417122,0.04343874,0.049517483,-0.0429237,0.062348768,-0.017751845,0.04121599,-0.09533116,-0.017677655,0.014977875,-0.014423334,-0.0046473662,0.020687168,0.052947294,-0.08469809,0.041621033,0.00014755107,0.001881387,-0.08274998,-0.0063060164,-0.03951026,0.08509769,0.050462697,-0.06134691,-0.0030307863,-0.039641697,-0.040595435,-0.06325976,0.014621843,-0.04851073,-0.016010085,-0.0074562537,-0.015056619,0.0014426026,-0.03001939,0.050656453,0.046707593,0.09713539,-0.03608201,0.10451726,0.025002798,0.019171203,0.035500366,-0.08602172,0.022985095,0.03388683,0.020286238,-0.033141397,-0.12434724,0.07270872,0.003495458,0.13559158,0.010904561,-0.010251558,0.059934888,0.007808321,0.043312136,0.025142428,0.110191874,0.025183856,0.03418434,-0.022944037,-0.051076036,-0.044752534,-0.0121857505,-0.041489035,-0.039839268,0.004120276,-0.01308573,-0.012151157,0.07379041,-0.05614772,-0.00082512473,-0.12697843,0.021620374,-0.06585867,-0.062953815,0.008090226,0.004588145,-0.08189052,0.021906327,-0.034915574,-0.03256182,0.047763433,0.12512006,0.023280365,-0.0044269813,0.0077528683,-0.025774265,2.5754697e-33,0.00717633,0.03114521,-0.017198933,0.032546565,-0.01716307,0.0067858384,-0.046834785,0.014645637,0.00051227456,-0.07897483,-0.15410766,0.03342331,0.015480637,0.045470547,0.063533105,0.02789667,0.05141223,-0.077041656,0.06659871,-0.07895507,0.07836424,-0.020564228,-0.064265475,0.064309835,-0.005477417,0.015189575,-0.045261256,0.02486088,-0.013153037,0.00046687818,0.0097205695,-0.067438185,0.039520722,0.04178547,-0.008018361,0.05433961,-0.023387223,-0.056841034,-0.031141784,-0.03390915,-0.019567158,0.004378076,-0.03629186,0.071139544,0.023043366,0.022545146,-0.0043898122,-0.00013535866,0.06277652,0.08877826,-0.029135805,-0.01801883,0.01716661,0.08149185,-0.0074068788,0.024251532,-0.038385358,0.06533422,0.03155834,0.04996661,-0.034234174,0.07720427,-0.008022917,-0.047240242,-0.11810367,0.08630535,-0.031009834,-0.041110788,-0.015964538,0.055836715,0.051845305,-0.024100356,0.054586723,0.04454714,0.12537359,-0.022555802,-0.053181324,-0.026484516,0.020327747,0.016253999,-0.032029048,0.0043077855,0.015465144,0.108291484,-0.124683574,0.024458703,-0.029650792,-0.016343676,0.11412223,0.047050793,-0.016289052,-0.023815978,0.0018599448,0.01684153,0.06403427,-3.489934e-33,0.04298706,-0.036521804,0.018197216,0.0388436,0.0038239243,0.050237384,-0.025712544,-0.101642735,0.07307903,-0.0038722549,0.066466786,-0.03887414,0.041992635,-0.034391504,0.005100929,-0.033943973,-0.07531425,0.07020879,-0.016623463,0.026885325,-0.059776057,-0.016794873,-0.00078209315,0.040139515,0.032506518,0.0077326805,0.018180624,-0.064239524,0.022397356,0.06335988,-0.06631153,0.008883199,-0.052777465,-0.0096765645,0.013916212,-0.0021025678,-0.0013377497,0.036857255,-0.097110115,0.05121654,0.016176961,0.003139627,0.01669137,0.05279193,0.048199765,0.066835284,0.0365766,0.033792958,-0.003191093,-0.049841203,0.03396942,0.09063115,-0.016220186,0.0982202,0.0734766,0.04787129,0.06251529,-0.0067694616,0.018740142,0.0011184472,-0.055905677,-0.13898484,0.09510231,-0.021229995,0.088560626,0.0030527068,0.015081614,0.12277776,0.0005178009,0.023228137,0.059651025,-0.16377862,0.032035064,0.08831436,0.076316506,-0.020656943,-0.05859678,-0.033988096,-0.025569974,-0.01730766,-0.0054411604,-0.02784412,0.047867525,-0.060329705,0.0018327954,-0.057855703,0.012887055,-0.012077573,-0.01530225,0.050528176,-0.0075744237,0.01658083,-0.044296015,0.00667098,0.023905337,-3.447988e-08,-0.018182825,-0.039191708,0.010972957,-0.0056339717,0.03773447,0.021077534,-0.07238268,0.018643232,-0.038895342,0.049179025,-0.040888436,0.08334041,0.0023786451,-0.06307652,0.037413515,-0.04177774,0.034135725,0.02835524,0.017798899,0.016255489,-0.115940444,0.012786656,-0.0437455,-0.095615454,-0.021127623,-0.051989898,-0.034799773,0.064726174,0.06626648,-0.00801302,0.07686525,0.01692111,0.024522498,-0.018120265,-0.104144685,-0.019426512,0.04784806,-0.03536287,-0.037173636,0.073457815,-0.073351495,-0.03346143,-0.035611283,0.021301635,-0.016011024,0.024178863,0.022715818,-0.01388619,-0.038154848,-0.026518188,-0.009215067,-0.020132381,-0.024226518,-0.0019712797,-0.024310807,-0.052252855,-0.024157342,-0.019118188,0.021325648,-0.09178201,-0.049656045,0.013996802,0.13091315,-0.0031381303 +2.4.1.82,"4-Nitrophenyl alpha-D-galactopyranoside can also act as donor. The enzyme also catalyses an exchange reaction between raffinose and sucrose (cf. EC 2.4.1.123, inositol 3-alpha-galactosyltransferase).",384,1.0,0.012248666,-0.073519446,-0.10632439,0.00088645885,0.0742883,0.011548221,0.017740726,0.007898244,0.030806005,0.018087694,-0.04309347,0.025268262,-0.1210644,0.084528476,-0.035750117,0.07098281,-0.0380523,0.032744937,-0.0179641,0.032705273,0.11226407,-0.12479441,0.026349634,0.00052129466,0.09561865,-0.0635052,-0.015164091,-0.08785572,-0.024508066,-0.08002589,-0.015676199,-0.03142051,0.016054189,-0.0536283,0.015481519,0.073231734,-0.028087832,-0.04101577,-0.02452285,-0.026503986,0.0068933996,-0.043131694,0.030800005,0.03681021,-0.036678456,-0.01989064,-0.022237591,0.045323305,0.08527214,-0.024160443,-0.006603071,-0.07824094,-0.04925237,0.013732327,0.05805639,0.11193722,-0.02357194,-0.09882224,0.023837712,-0.01657404,0.07587635,0.0556967,-0.0023244114,-0.005537778,-0.013576558,-0.019480538,0.05555624,-0.0036114657,0.012256921,-0.044535775,0.010100808,-0.060473695,0.009701734,0.016606947,0.08850149,0.030515332,0.027099378,0.041157987,0.04314205,0.010842614,0.04463788,0.03241547,0.011107638,-0.015312727,0.04174328,0.03555906,0.0049481923,0.05857542,0.022485062,0.023974003,-0.045757115,-0.01486047,0.023984103,-0.014794362,-0.074131705,0.019317461,0.02517509,-0.015505992,0.08237836,0.015622898,0.011134989,0.052545395,-0.011787694,-0.07732841,-0.083667874,0.06445178,-0.020140063,0.05413161,0.02172331,0.028126074,-0.01867197,-0.039454512,0.08062728,0.06981941,-0.073825024,0.09083835,-0.077398576,-0.09934934,-0.09020137,-0.017593702,0.048299003,0.019714516,0.07313403,0.048256975,-0.015344624,0.11670515,-0.062416375,3.7575217e-33,0.056056485,0.06411866,0.05233361,0.010782526,-0.013542019,-0.023644758,-0.041681554,-0.035548545,-0.049144458,0.0175393,-0.120799616,-0.10530476,0.060448613,0.0043080235,-0.02843904,0.035125636,0.023618788,0.0005632749,0.037551813,0.04580311,-0.0363634,0.083492436,-0.07276299,-0.012712452,0.068457104,0.0053299963,-0.07626858,0.044640884,0.14282207,-0.0063026454,0.05946556,-0.01775254,-0.084578045,0.014554537,0.022686377,-0.0034488877,0.011980034,-0.07736145,-0.045159485,0.054977674,-0.02081474,0.019952893,0.0025686803,-0.013376672,0.054971248,-0.07122524,-0.01639995,-0.021714646,0.04741018,0.0055459375,-0.0234216,-0.05483491,0.028288217,-0.021365862,-0.022006229,0.02645419,-0.01971298,-0.00775266,0.069919854,-0.00096848526,-0.0073986053,-0.018411085,-0.0003462516,-0.023715708,-0.01836606,0.0004609399,-0.0074053966,-0.053935815,-0.0724149,0.018000254,-0.086888716,-0.029913457,-0.011978781,0.014789083,0.02035982,-0.084199436,-0.0043448736,-0.01593354,0.044262778,-0.019336296,0.013755556,-0.0017970919,-0.022172177,-0.0034470377,0.032563172,-0.02033155,-0.09315745,-0.10813656,0.029130656,0.04934614,-0.060839757,-0.049255915,-0.08047981,-0.033880066,0.053928424,-3.887658e-33,0.08557298,-0.101753235,0.012287174,-0.06272839,-0.020899208,0.108568445,0.05277064,-0.06977461,0.058386154,-0.01324784,0.035749484,-0.044183034,0.06751762,-0.08672192,0.023552012,-0.06470166,0.029811298,0.029863842,-0.019604115,-0.047620475,0.034400903,0.10204272,-0.014177702,-0.002068092,5.658636e-05,-0.026344666,-0.0068882164,0.08181205,0.06699959,0.020446917,0.051886562,-0.04837447,-0.06110744,-0.057624593,-0.007181515,0.024083652,0.041327212,-0.0028775004,-0.02333781,0.036086224,-0.04552377,0.059391297,0.068555586,0.06251127,0.022274649,0.039879676,-0.09422242,0.020369396,0.12762682,-0.038704783,0.030061994,-0.03387085,-0.01121588,0.03675834,0.06752348,0.008077615,0.075486444,0.0036627,0.049570985,-0.043978706,-0.06307178,-0.0434163,0.05639755,-0.05216159,0.06747495,0.017714476,-0.054724038,0.057539903,0.005467878,-0.008487946,0.045179553,-0.05464777,-0.022925198,0.12832037,0.019064935,-0.06197435,-0.08103466,-0.048745476,0.039936956,-0.052627083,0.02638825,0.016322007,0.055509992,-0.011236543,0.01018488,-0.072645694,0.0942438,0.086337656,0.009150709,-0.039444555,-0.05344259,0.009140472,0.028908921,-0.011864025,0.071821444,-3.8193487e-08,0.030770216,0.029637644,-0.0038847895,-0.05826253,-0.055869482,-0.0021157537,-0.019908201,-0.019461459,-0.005037323,-0.050200596,-0.05544897,0.1487578,0.05430953,0.00017729429,-0.0012182188,-0.016388133,0.04208765,-0.02699966,-0.032651607,-0.026296126,-0.057429902,-0.0031017745,-0.084369645,0.021033864,0.0076478343,-0.03632731,0.068964265,0.076207176,0.01383573,-0.028128121,-0.030938629,0.013171089,0.0061388435,-0.0059674773,-0.04188156,0.049637448,-0.01160459,0.009424588,0.056496266,0.0012088366,0.0195614,-0.07599683,-0.016136605,-0.011465872,-0.09207709,0.019038716,-0.014562635,0.00056000415,-0.035919093,0.05759009,0.036141142,-0.10021301,-0.08152125,-0.02862378,-0.054004107,-0.024495292,0.019267231,-0.005427693,0.14348331,-0.068304315,0.049770694,-0.04999229,0.12770237,-0.023813374 +2.4.1.83,Acts only on long-chain polyprenyl phosphates and alpha-dihydropolyprenyl phosphates that are larger than C35.,384,1.0,-0.06946665,-0.13070907,0.071217395,-0.104447536,0.0844839,-0.032914147,0.0005984731,-0.012288147,-0.06389175,0.05302928,0.008188319,0.035714008,-0.11214033,0.07425808,-0.004154791,-0.015248892,0.005060625,0.04158321,0.023404848,-0.0016767037,0.03619212,-0.091059364,-0.05556045,0.01392513,-0.019648124,0.049860813,-0.022090498,0.047597673,-0.013505552,-0.11787108,-0.064184025,0.0013463118,-0.002211844,-0.053467162,-0.0005170378,0.044144467,-0.15055561,-0.030139007,0.05512605,0.0329297,0.09251543,-0.04573107,0.03437835,0.085464485,-0.040123645,-0.040830735,-0.058493216,0.012332749,-0.061145294,0.018946018,-0.103126705,0.003917045,-0.008829214,-0.0068656635,-0.049113512,-0.063522846,-0.09547234,0.07018463,-0.015489978,-0.03272796,0.01600926,0.0014368269,0.007688168,0.02056096,0.006290839,0.024267899,0.06527012,-0.034069557,0.016025502,-0.021255214,-0.04327049,0.01962125,0.013144066,0.024345249,0.05536873,0.024894523,-0.040849473,-0.010058528,-0.01716972,0.027051516,0.003990612,0.051565956,0.012728013,0.035960305,0.072410695,0.039456632,-0.011627285,-0.026303984,-0.03615922,-0.0032055588,-0.00015905077,0.008635371,-0.019204909,-0.03141408,-0.0053464007,-0.0014448038,-0.0017818873,-0.032567732,-0.066562176,0.00324317,-0.03143462,0.042044207,-0.0082997475,-0.049104687,-0.056681685,-0.014661585,-0.058417898,-0.047153965,0.013669957,0.05153263,-0.038141366,0.00089687994,-0.011805645,-0.037802637,-0.007885861,-0.030694764,-0.040955767,0.009670359,-0.011026138,-0.03211475,-0.03386906,-0.07017089,-0.032201048,-0.021506384,-0.13802545,0.033540078,-0.11183774,2.7552655e-33,0.067182876,0.0027542475,0.049524494,0.016126268,-0.0083468035,0.056841224,-0.06291232,-0.009940536,-0.09603662,-0.01848221,-0.012403608,-0.045894302,0.08919914,-0.044470947,0.03107359,0.0116050495,-0.01819463,0.04749237,0.017118651,-0.11874727,0.053989917,0.09578738,-0.10956805,-0.013561922,0.06798444,-0.048575457,-0.0935734,0.054738726,0.041676685,-0.0057116556,-0.00523095,0.013174256,-0.022818005,0.037499044,0.0646178,-0.05802848,-0.090873495,-0.056271896,0.023886882,-0.015021918,0.0132651515,0.048708253,0.049443588,-0.017168503,0.010456694,-0.054702047,-0.0059563695,0.04814587,-0.03677337,0.006976637,0.05865723,-0.004772888,-0.044333693,0.014200802,0.010766877,0.068021744,-0.018484835,-0.030671677,-0.011422569,0.03220584,0.043668974,0.050728325,0.008377542,-0.035563745,0.04951056,0.010230169,-0.047101837,-0.011418957,0.060739096,0.055778813,0.047472235,-0.039005265,0.07572429,-0.00148903,0.096725,-0.007271921,0.019676441,0.015681004,0.088427626,-0.022239977,0.03245095,-0.12842049,0.028213497,-0.019118888,-0.027387993,0.01739591,-0.016371377,-0.0976518,0.051133145,0.05145909,0.104518995,-0.14896761,0.013508458,-0.0047273957,-0.047395192,-3.6909593e-33,0.11271343,-0.056641255,0.037381086,0.038294345,-0.06838629,-0.013903271,0.0073063965,-0.043528248,0.010124844,-0.007874012,0.121737204,0.035576295,-0.012150358,0.023889052,0.027284374,0.10960739,0.03289099,0.041125547,-0.049835123,0.041955967,0.0697612,0.01920671,0.041307677,0.14029835,-0.046403304,0.056795623,0.029193671,0.009439046,0.024238812,0.009094355,-0.10012771,0.026997874,-0.12055513,-0.035556637,-0.029016636,-0.06593735,-0.095656686,0.04084455,-0.00095393613,-0.009224081,0.0123938965,-0.025247863,0.0058812164,-0.030387772,-0.044561688,-0.017548766,0.040399514,0.012665192,0.06119451,-0.04595387,-0.046270255,-0.00710326,-0.010511012,0.03762798,0.03176833,0.08665319,0.06442511,0.020352742,-0.044007767,-0.0071508945,0.02611142,0.012094856,0.05257382,-0.03869782,0.052767374,0.029262833,-0.023891475,0.057907324,0.062069587,-0.06373011,-0.006747102,0.017226735,0.08725363,-0.010813909,-0.065328926,-0.099992946,0.0093406355,-0.023364084,0.025716748,0.009759349,0.065055095,0.015708443,-0.046406724,-0.010806718,0.003690344,0.0047214213,0.045992203,0.08102259,0.06450345,0.09877444,0.008188279,0.09426355,0.09881312,0.045369413,0.1149949,-2.755151e-08,0.055351105,0.041862957,0.04352266,-0.04804546,-0.096610636,0.0063893506,-0.021525074,-0.005954663,0.057506125,0.032779116,0.022646371,0.07943633,0.051010724,0.039282124,0.09503766,-0.01733041,-0.052797955,-0.07061457,-0.023259392,-0.05987667,-0.13842843,-0.059928935,-0.025838802,0.06808441,-0.0449875,-0.040973138,0.044628654,0.037959516,-0.031804122,0.04876383,-0.027456457,-0.005363437,0.018080082,-0.0011751143,0.042357206,0.03830704,0.039539963,-0.013478815,-0.04034394,0.025894292,0.0041014166,-0.10425048,-0.05218392,0.05482395,0.011240853,0.0042723143,-0.057316296,0.0258842,-0.015929574,-0.011770684,0.018569503,0.10468085,-0.05442713,-0.00067291205,0.020576792,-0.009797376,-0.048262093,0.037982836,0.0047495393,-0.041579414,0.0050782613,-0.056718282,0.06991312,-0.030936547 +2.4.1.85,"Acts on a wide range of substrates in vitro, including cyanohydrins, terpenoids, phenolics, hexanol derivatives and plant hormones, in a regiospecific manner [3]. This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.14.36, tyrosine N-monooxygenase and EC 1.14.14.37, 4-hydroxyphenylacetaldehyde oxime monooxygenase. This reaction prevents the disocciation and release of toxic hydrogen cyanide [3].",384,0.99999994,-0.10013236,0.0030995628,-0.06132746,0.025832416,0.074171536,0.042955324,-0.077071734,0.01736159,-0.024309034,-1.2394931e-05,0.064491786,-0.018270206,-0.13016187,-0.052081622,-0.07543898,0.035057627,0.005059997,0.07672227,-0.0017593966,-0.023598151,0.041632548,0.031504814,0.015911454,0.014838422,0.028600715,0.02284224,-0.031342044,0.033257768,-0.037544183,-0.016724356,-0.0043810573,0.012845142,0.017463917,-0.03836796,-0.016582903,0.081958644,-0.0043478347,-0.098654665,0.03999561,-0.06477917,0.040521596,-0.07320776,-0.033838954,-0.044696394,0.032301318,-0.031097354,-0.013729037,0.007874416,0.020823792,-0.019552322,0.03222066,0.005710446,0.016307836,-0.036557216,-0.0052331835,-0.04487647,-0.033486962,0.0031085033,0.018576143,0.060664933,-0.017180556,-0.0075916,-0.04882503,0.008549814,-0.022872653,-0.044189803,-0.09898132,-0.0725575,0.04414811,-0.052115757,0.006096451,-0.10199237,-0.0059121572,-0.039122414,-0.09467107,0.15625517,0.026364807,-0.069109425,0.0047339182,-0.036577173,0.10233038,0.050983474,0.11483473,0.06869294,0.00015363558,-0.040226836,-0.023365255,0.027552666,-0.004089162,0.06480113,0.08491444,0.060804497,0.006918795,0.030954538,-0.020244997,0.0454276,0.124321364,0.016934102,0.019712236,-0.013574714,0.011057869,0.02051115,-0.030636141,-0.025489772,-0.0049738046,0.041209906,-0.06631942,0.006644064,0.053648446,0.0052523147,-0.02241629,-0.00056093856,-0.074118964,-0.020404631,-0.026670596,0.05655221,0.0008313723,-0.027125664,-0.072651446,-0.042568397,-0.034289923,0.0014440318,0.040229086,0.07206883,-0.0018880663,-0.006723947,-0.0138266,4.81945e-33,0.051236425,0.016071334,-0.032584272,-0.043990396,-0.0059327134,-0.020150019,-0.041937303,0.07385148,0.0645945,-0.08280135,-0.05062873,-0.057320878,0.022133159,-0.021561338,-0.066488415,-0.008666763,-0.060945027,0.0023201006,0.11808356,-0.022800263,-0.032670274,-0.057366423,-0.092965044,-0.011870173,-0.036565967,0.01189608,-0.0032530879,-0.002993012,0.049162533,-0.017987078,0.023382615,-0.112085305,0.0049847257,-0.04076709,0.041549146,0.013435735,-0.081008844,-0.024739256,-0.08483265,0.038116947,-0.07040552,0.012740541,0.0074328915,-0.027166665,0.032672834,0.010309838,-0.05949957,0.07047347,-0.011800985,0.0069704778,0.072017394,-0.032765392,0.047226492,0.03079106,0.0014994489,0.066576876,-0.015860807,-0.043000605,0.021165464,0.07638657,0.011660309,0.057369053,-0.011221091,0.025835903,-0.0014990277,0.0048358818,-0.06423402,-0.04873057,-0.061483666,0.046241842,-0.009620468,-0.037098538,0.04194183,0.018516492,-0.022743315,0.048929073,0.030901901,0.04836433,0.03573215,0.034826215,0.027010173,0.03319215,0.02071096,-0.011730542,-0.0045898943,0.048626292,-0.082810245,-0.064052135,0.033828005,0.06725859,0.0831437,-0.10021864,-0.04577695,-0.018810602,-0.0114255585,-5.9874154e-33,0.063420236,-0.027558919,-0.0100008575,-0.059823185,-0.03675355,0.07266903,-0.010360661,-0.003887118,0.029097473,0.026056467,0.06918705,0.011891193,0.075317614,-0.052453786,-0.03859293,-0.06215499,-0.014152481,0.15146136,-0.0774033,0.057220127,-0.00035765514,0.03585455,0.017948693,-0.004085567,0.04985531,-0.036598306,-0.031754952,-0.04486462,0.00097177713,0.08248032,-0.006662364,0.0016510141,-0.08502376,0.013040977,0.17246006,0.067579694,-0.056840166,-0.0040519265,0.0391021,0.011011853,-0.08062755,0.0013408399,-0.016350249,0.097438455,0.08465953,0.038739853,-0.12706243,0.034226406,-0.013892663,0.062060423,-0.006481904,0.048821695,-0.060620647,0.02272956,0.035753608,0.01125269,0.0812843,-0.05727596,-0.018767398,0.0038322983,-0.017387569,-0.05123527,-0.010085081,-0.021516005,0.00043741873,0.056991547,-0.041335594,0.063778944,0.008503055,-0.024722874,0.06913842,-0.022599217,0.048474956,0.021903843,-0.08087534,-0.022876484,0.0798356,-0.044904977,-0.031403333,-0.009216709,0.057965435,0.054684147,0.047127996,0.0077629187,-0.019851534,-0.052151766,0.054295134,0.124088824,-0.03628679,0.032554388,0.025301741,0.004345623,-0.06938513,0.07730865,0.062535115,-4.8282715e-08,-0.08721315,-0.048396084,0.08780275,-0.05489646,0.0009837074,0.08933314,0.055088896,-0.024806656,0.029565843,-0.03167167,-0.009782545,0.12795891,-0.061205313,-0.0094059035,-0.023388691,-0.042010445,-0.01400882,0.005037874,0.0026557918,0.0027204293,-0.04899449,-0.020035492,-0.0887626,-0.03572692,-0.013894842,-0.1293725,0.056733865,0.037039127,0.0477766,0.00023561875,0.062113438,-0.0057656844,-0.06066473,-0.020904934,-0.015768994,0.022482675,-0.017466202,-0.009318839,-0.021322059,-0.019783143,-0.14431964,-0.029755883,-0.0005105799,0.015031805,0.01214139,-0.014650763,-0.014077444,0.07227596,-0.048095483,0.0915397,-0.0021988177,-0.055430107,0.06299438,-0.07377395,0.0038146328,-0.035953432,0.07463869,-0.03341852,-0.04647947,-0.015832968,-0.053875946,-0.0053112344,0.18248807,0.045266636 +2.4.1.86,"The enzyme transfers galactose from UDP-alpha-D-galactose to the 3-position of substrates with a non-reducing terminal N-acetyl-beta-D-glucosamine (beta-GlcNAc) residue. It can act on both glycolipids and glycoproteins, generating a structure known as the type 1 histo-blood group antigen precursor. ",384,1.0,-0.0078809885,-0.10121268,-0.08869131,-0.04203906,0.01286905,0.006519913,0.03666194,0.019985294,-0.009781836,0.036417957,0.019477533,0.065739036,-0.06962119,0.0521263,-0.09576596,-0.04476392,0.008909181,-0.003187886,0.0003612238,0.010532437,0.13221835,-0.042049136,-0.0041039158,-0.01788487,0.0907555,-0.049854178,0.038817573,-0.07854242,0.013039546,-0.09635374,-0.031573415,-0.075822905,0.07463194,-0.0027937707,0.016363138,0.023342738,0.015050533,-0.024766425,-0.017656393,0.00010880286,0.029068049,-0.027525732,0.0051611597,-0.017491577,-0.040559,-0.01624379,-0.04160445,0.09962043,0.0438382,0.023483824,0.063618675,-0.08739466,-0.02503934,0.0049914033,0.041530557,0.06781993,-0.072407365,-0.06674623,0.021990037,0.035894778,0.03790114,0.06713483,-0.0029279746,0.014766421,0.037818942,-0.094171286,0.07149089,-0.021645848,-0.065124065,0.01493409,-0.051884998,-0.05095652,-0.03898646,-0.022715796,0.068902865,0.025177998,-0.035245225,0.0369799,0.053078108,-0.017944647,0.06723368,0.024458442,0.039287407,0.12251719,-0.06708928,0.047066253,0.0034812347,0.038045056,-0.027542567,-0.018336155,-0.0035823972,-0.067831546,-0.008549381,-0.0131578185,-0.06906253,-0.0018779205,0.047576964,-0.027580833,0.07391904,-0.029940035,-0.019194625,0.030660842,0.0845135,-0.027561272,-0.049246628,0.057803698,-0.06696394,0.051868632,0.04165949,0.008923905,-0.016456425,0.017082954,0.029207896,-0.011493239,-0.07945116,0.077605695,-0.037504062,-0.05796979,-0.040193114,-0.02929539,0.071509674,0.025515905,0.046150297,0.073293515,0.00530584,0.097038075,0.008786603,-2.5559167e-35,0.10682889,0.057212725,0.0106857205,-0.01903108,-0.015678091,0.003912901,-0.03784871,-0.036690034,-0.0045024604,0.054384377,-0.05688885,-0.050171636,0.06039108,0.10412555,-0.041987073,0.0775621,0.0076109087,-0.08206306,0.046262175,0.01740558,-0.06487271,0.078406885,-0.038801394,-0.06803414,0.06722156,0.07217709,-0.090269625,0.091046154,0.05301397,0.012823352,0.0061191316,-0.03814241,-0.095663786,0.039959658,0.049175162,0.03322643,0.001415124,-0.08617378,0.036311653,0.027860709,0.05082609,-0.020330755,-0.020314712,-0.007941717,0.024728611,-0.032084145,-0.047235828,-0.015120526,-0.019986583,0.069958754,0.046457943,-0.014174738,0.042520348,-0.023243254,-0.03201595,0.06049039,-0.04681849,-0.015491836,0.01747373,0.0911624,0.0063157673,0.041872256,-0.033923715,0.025848135,0.031749353,0.027106391,-0.05602712,-0.050503027,-0.030860554,-0.017066833,-0.04736444,-0.07485685,0.046529133,0.021915967,0.006351858,-0.023431689,0.010318969,0.04652037,-0.0016401315,-0.04244248,-0.036024723,0.025767585,-0.03815218,-0.027323881,-0.055411194,0.007780122,0.0128564155,-0.13211943,-0.047465865,0.0034816817,-0.04607613,-0.022611577,-0.019080203,0.05751527,-0.0010942825,-2.881039e-33,0.1142075,-0.1023481,0.05703892,-0.041118335,-0.034808178,0.028165253,0.07986795,-0.052169736,0.02476165,0.017119592,0.023913767,0.010224856,-0.06629791,-0.0629521,0.02647251,0.010185907,-0.022881135,0.057915945,-0.07607828,0.016405981,0.005235844,0.08140247,0.025172943,0.024746701,0.027390135,-0.04607499,0.036554944,0.030046515,0.016735883,0.009422604,0.017471269,-0.012201322,-0.00070485513,-0.100009225,-0.03662529,0.013499654,-0.048719954,0.019755635,0.017843524,-0.03309023,-0.015034343,0.047500167,0.017249968,0.010838442,0.124505386,0.10497229,-0.08002401,0.037498098,0.04035644,-0.031490505,-0.024584023,-0.0049143764,0.028047431,0.069569245,0.02897702,0.06397715,0.1139967,0.007742739,0.041126717,0.008445509,-0.02898145,-0.011270687,0.025863936,-0.043788254,0.10267053,-0.025826786,-0.0013452375,-0.010500183,0.027150678,0.006963873,-0.015984654,-0.06943199,0.03002359,0.03553125,0.005143721,-0.029852495,-0.14788873,-0.047523554,-0.0012796624,-0.036314104,0.036466975,0.03919539,-0.010845725,0.020369362,0.045277435,-0.09275028,0.050404463,0.12635155,0.013266775,0.031328667,-0.0625873,0.0052426094,-0.043273635,0.0077910195,0.0690185,-3.9751598e-08,0.11447433,-0.01111641,-0.0028903207,-0.10947405,-0.04575034,0.033701576,-0.07025921,-0.01150559,0.046015806,-0.022330957,-0.0812276,0.14678048,-0.0028692686,-0.015903698,-0.016537458,0.050862513,-0.018511593,-0.03989626,-0.05665205,-0.020967644,-0.09513556,-0.007813659,-0.091027535,-0.026654525,-0.017423604,-0.1014751,0.025276463,0.09157063,-0.041770212,-0.017898351,-0.00045598528,0.08817442,-0.03467823,-0.036792528,-0.049604896,0.020980468,-0.017991792,-0.014980319,0.086722925,-0.008319029,0.014853535,-0.03094573,0.0041154805,-0.034254633,-0.04613783,0.0023550005,-0.0072784014,-0.0043223933,-0.043994363,0.07853165,-0.044066448,-0.04742327,-0.10560181,-0.078541815,-0.06798932,-0.07117648,-0.03465917,-0.058197346,0.060731575,-0.053902972,-0.017191704,-0.009652606,0.13257834,-0.019403512 +2.4.1.345,"Requires Mg2+. The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). ",384,1.0,-0.08695095,-0.0674542,-0.043868724,-0.0011323865,0.0021529258,-0.015699182,-0.0032752932,0.045679696,0.008394305,0.08701635,0.04373713,-0.03585101,-0.0037331786,-0.009022933,0.0030938748,0.066602014,-0.013577716,0.083871685,-0.004928329,-0.035065256,0.09579586,0.032023016,-0.0038803814,0.034530506,-0.017750325,-0.0011527138,0.077547714,-0.021071393,0.036579315,-0.048457365,-0.026171211,0.007649511,0.03440652,-0.08233846,0.08869187,0.1262067,-0.02453211,-0.103452675,0.08503844,-0.055360243,0.0471586,0.014873698,0.07624375,-0.027269246,-0.037296265,-0.009953757,0.015558253,0.008024958,0.06993346,0.023354392,-0.07219822,-0.024804099,-0.08324164,-0.006567727,-0.0031003451,0.052480042,-0.13636504,-0.013159224,0.017060162,0.0023743557,-0.037725214,-0.015260284,-0.0047841463,0.04652006,-0.03414175,0.0045352723,0.014823106,-0.063224584,0.03631431,-0.0005271901,0.0008889202,-0.044150107,-0.037411645,0.089512385,-0.028547257,0.03449855,0.023621157,-0.07783243,0.008355068,0.026727902,-0.018728523,0.0062030577,0.054892458,0.013268748,0.023285592,0.01424689,0.061832502,0.050723717,0.05558441,0.090726934,0.08012038,0.024576606,0.041195568,-0.033457085,0.015556135,0.006095704,-0.008751942,0.015988832,0.017618222,-0.013045241,0.025061319,0.049944602,-0.017137192,-0.036418412,-0.045647446,-0.021833293,-0.014805121,-0.05548904,0.036899123,0.10969915,0.08411188,-0.011795844,0.018214006,-0.039697442,-0.02235154,0.035868518,0.050328735,-0.14973493,-0.03298088,0.00052052626,-0.003350145,-0.06748748,-0.057927474,0.045896247,-0.10441724,0.032313112,-0.087651715,1.0898465e-33,-0.04267089,-0.0122298505,0.075639255,0.01646269,0.028094135,0.0052265683,0.0003081567,-0.088823125,-0.04452536,-0.10002269,-0.16026132,-0.043507762,-0.03272095,0.020302,-0.07918872,0.024619969,-0.018833298,0.0155608915,0.07459171,0.069555625,-0.05608648,0.031793118,0.014046285,-0.00379825,0.035284862,0.14701891,-0.01374141,-0.100629784,0.096286684,-0.013022858,0.048835937,-0.10228952,-0.073403955,0.0018655551,0.011573588,-0.047901675,-0.05474936,-0.0615817,0.006543712,0.05801483,-0.05569658,0.028921237,-0.03832953,0.036667693,0.028229361,-0.063006796,-0.004785574,0.03268448,-0.0074266177,0.027535278,0.06738259,0.0019974327,0.021893825,0.022746518,-0.05046054,-0.020877184,-0.046177853,-0.008794645,0.06634631,0.060081348,0.03126955,0.04871062,0.07899119,0.057532396,0.052640438,0.0034392152,-0.10627306,0.028589683,-0.004274822,0.04131434,-0.003918365,-0.1052772,-0.009171535,-0.010959482,0.044526055,-0.048896935,-0.009494628,-0.02530372,-0.047508765,0.021859623,0.053520642,-0.045391083,0.032993764,0.035139572,-0.08485927,-0.032487467,-0.019890679,-0.029818183,-0.008366661,0.021117866,0.027556844,-0.015606696,-0.06537829,0.123171575,-0.06072523,-3.809394e-33,0.061912123,-0.059792284,0.094897285,-0.05549413,-0.07856973,0.013901393,0.064424686,-0.10612158,0.09882994,0.045884736,0.06048121,-0.0205173,0.015359251,-0.051085122,-0.0367536,-0.0061920555,0.0022190064,0.096049696,-0.044589225,-0.027727164,-0.05079337,0.13442072,0.03558222,0.03961877,0.009827298,-0.0009233668,-0.064719655,0.008278197,0.008431881,0.09361756,0.0067054555,0.051253457,-0.05579479,-0.06312796,-0.06268603,0.02449748,0.024110148,-0.0007157587,-0.0033642196,0.019077836,-0.0118021695,0.03384281,0.06847762,0.05921312,-0.01783303,-0.013985772,0.0069190143,0.045869675,-0.06083784,-0.031774815,-0.060204655,-0.006566198,-0.028959217,-0.0054583666,0.0126472805,0.012267787,-0.030955734,0.025854196,0.02068444,-0.06142968,-0.058305386,-0.1151544,0.037421815,-0.03526294,0.02622925,0.120070465,-0.011259501,0.03379672,0.033077184,0.02375823,0.033697516,0.08282235,-0.008344166,-0.0022700205,0.008063372,0.09541978,-0.060945805,-0.06725109,0.025739847,-0.073325135,-0.07010686,-0.022093866,-0.038512275,0.014600523,-0.008535543,-0.11505444,0.077324174,0.046492368,-0.037996735,0.032115754,-0.031137427,-0.051717937,-0.05936754,0.06434989,-0.020932099,-3.1981862e-08,-0.01766263,-0.076946154,0.025902316,-0.05943187,0.015464499,0.053961113,-0.029811062,0.023033826,0.05045552,-0.003918808,0.015152075,-0.03930818,0.032963227,0.014726022,0.07745984,0.06679344,-0.06512281,0.033418,-0.023024576,-0.06688592,-0.077823855,-0.03101101,-0.052822556,0.050842587,0.0124651035,-0.0272311,0.06300136,0.07887959,-0.07390129,0.019509729,0.0025876553,-0.002960908,-0.072315276,-0.038377948,-0.046523172,0.024878005,-0.01839101,-0.0077856136,-0.016404623,-0.06710031,-0.068259664,-0.004337723,0.026887825,0.0038069498,-0.040895034,0.055789918,0.0014599359,0.036205273,0.0012523571,0.050203484,0.046559643,-0.019602846,-0.039638277,-0.036809992,-0.047838327,-0.037364107,0.023581002,-0.0447768,-0.018250665,-0.05876699,0.029278854,0.04163867,0.12770388,-0.06214444 +2.4.1.87,"Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.",384,1.0,-0.0004896658,-0.105899684,-0.05731161,-0.034481794,0.054328065,0.01686113,0.03406284,0.016589534,-0.025309855,0.027901288,0.069445595,0.04906515,-0.015181673,0.07329081,-0.0899186,-0.0022033742,0.039957415,-0.04727666,0.02003321,0.047717337,0.009232665,-0.032704223,-0.011851284,-0.003425683,0.037398826,-0.006904273,-0.050184995,-0.050229963,0.009071385,-0.12813757,-0.03881011,-0.009434001,0.07434987,0.006736651,0.061549664,-0.018027255,-0.028744768,-0.057221375,-0.00585398,0.025580838,0.0022671004,0.023374217,0.035811976,-0.038831778,-0.032241944,-0.052274708,0.009700907,-0.004474945,0.051396545,0.021554088,0.06862836,-0.017423501,-0.0029559848,0.06267156,0.013285567,0.020846004,-0.14300767,-0.009711885,-0.00976948,0.11008837,0.045252483,0.063376755,-0.02256453,-0.0035231179,-0.051684182,-0.046053343,0.0911511,-0.08081971,-0.019548282,0.06835851,-0.021848701,0.0051313885,0.049551662,-0.038982727,0.06200059,0.045841184,-0.03012042,-0.0015977655,0.03006552,-0.040394165,-0.006337414,-0.014492528,0.031800274,-0.013547391,-0.009278466,0.017943645,-0.015245412,-0.00050923316,0.03126797,0.023388987,0.027011838,-0.10170592,0.10201664,-0.042337354,-0.0014408751,-0.085381314,0.06897382,0.04556968,0.004644773,-0.02341024,-0.04109593,0.010608211,-0.007846181,-0.061518222,-0.040645026,0.070159726,0.003144839,0.009265976,0.06136158,0.039500322,-0.089819744,-0.0020603172,0.04088687,0.01929158,-0.09826388,0.026991151,0.0080710845,-0.11563973,-0.013103968,-0.044138532,0.046502315,-0.037296966,0.06241544,0.03673778,-0.020887569,0.07029818,-0.04104283,2.0529605e-33,0.05757106,0.08229858,0.092196636,-0.037031405,-0.024250824,0.00065187324,-0.06547366,-0.05443465,0.0029976391,-0.059319723,-0.065220155,0.040449496,0.05773777,0.073801525,-0.0051026787,0.049269702,0.041400943,-0.020938538,0.09517917,-0.036912713,-0.011403388,0.03638422,-0.07973618,-0.052601784,0.0024551903,0.046529282,-0.009677554,0.07209364,0.069726564,0.048706792,-0.00061099615,-0.056010433,-0.04099713,0.10352414,-0.0004687339,0.046677247,-0.02005278,-0.03967177,0.06746711,-0.06438495,0.05183887,0.061193183,-0.063328885,0.0010542651,0.010443206,-0.034019496,-0.0032594234,-0.008029623,0.0029162196,0.073165104,-0.047634173,-0.06243699,0.018570434,0.010436246,-0.004461616,0.04764948,-0.061962802,-0.067852624,-0.022080831,0.10793266,-0.011635938,0.057442527,-0.03199114,-0.07308707,-0.0033738422,0.027282951,-0.05950563,-0.051505275,-0.054105468,-0.05063375,-0.050403427,-0.041780803,0.104139596,0.069471434,0.046568505,-0.07401726,0.02154152,0.04492932,0.005928767,0.020386236,-0.040692978,0.008730211,-0.008264195,0.017768675,-0.043787677,0.0026972385,0.08363099,-0.051605612,0.016993009,0.06875302,0.008016324,-0.087740704,-0.016862603,0.07327877,0.0063776295,-4.1777356e-33,0.12914662,-0.081230134,0.056940775,-0.014726716,-0.028889513,0.024220563,0.045842648,-0.020580007,0.057155408,-0.029022623,0.06632253,-0.021316957,-0.013513392,-0.034001887,0.04273095,-0.07688241,-0.0355022,0.055945534,-0.016282927,0.041583836,-0.013421506,0.0020019456,-0.045317475,0.0018681645,-0.035101473,-0.01655435,0.02476396,-0.0062094345,-0.0046647317,0.069436,-0.075573266,0.041265987,-0.09748523,-0.06782175,-0.030830948,-0.06964809,-0.053425748,-0.0029731197,-0.033060152,-0.06497637,0.038933083,0.097216,0.024140125,0.013962861,0.10028981,0.07208739,-0.00879507,-0.0096273,-0.013946531,-0.048450004,-0.017329441,-0.016994165,-0.024310581,0.05504968,0.03516833,0.08314937,0.045662314,0.03651616,-0.020388467,-0.012918936,-0.014055155,-0.0021790268,-0.021156821,-0.081382066,0.077187754,-0.033056937,-0.010345094,0.070065685,0.08671433,-0.002364888,-0.052883267,-0.05798004,0.06528237,0.058042757,0.03477634,-0.015367675,-0.14423664,-0.11021736,0.0037939472,-0.071740024,0.0028610134,0.06525138,-0.032881465,-0.031477723,0.04967272,0.02789342,0.04836867,0.12135249,-0.03251012,0.011014992,-0.024044449,-0.015534835,-0.047574937,0.09388742,0.050273374,-4.4254147e-08,0.07765742,0.048847347,0.0119278785,-0.076224074,-0.039632652,0.041965604,-0.008708844,0.03633547,0.034221504,-0.038621314,-0.009252046,0.13079605,0.036733232,-0.027932847,-0.06801183,0.04606808,-0.090257004,0.0050139884,0.0039310344,0.05521738,-0.13256583,0.008263717,-0.035170108,-0.023425622,-0.07936598,-0.062110867,0.06357426,0.09370596,-0.094800554,-0.023460822,-0.013698417,0.03379355,-0.0820345,-0.07929266,-0.008376015,-0.052811198,0.0076555847,-0.0030334808,0.04931101,0.045691285,0.026898934,0.0012540198,-0.041719977,0.036296986,0.03827024,-0.0010484861,0.014262481,-0.0018296972,-0.036389664,0.017894018,-0.016659528,-0.0074444166,-0.108197875,-0.12213171,-0.038049858,-0.009346344,-0.037931483,-0.06188314,0.00937128,-0.011116865,-0.022145066,-0.08393863,0.05080855,0.053206507 +2.4.1.90,"The reaction is catalysed by a component of EC 2.4.1.22 (lactose synthase), which is identical with EC 2.4.1.38 (beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase), and by an enzyme from the Golgi apparatus of animal tissues. Formerly listed also as EC 2.4.1.98.",384,1.0,0.014478566,-0.028999079,-0.06887476,0.05445711,0.04099342,0.058462914,-0.04024403,0.051331688,0.03056322,-0.012645327,0.038270585,-0.032104943,-0.07937801,0.016454838,-0.06332583,-0.03798268,-0.04639708,-0.00021622913,0.019929245,-0.0559517,0.051340487,0.0047303913,0.015993664,0.029764913,0.07793993,-0.01740342,0.040913165,-0.093192905,0.004349536,-0.06832109,0.029689355,-0.105478674,0.041522667,-0.025582766,-0.023333317,0.0048449133,0.03456605,-0.12405927,0.036972154,0.016323013,0.031760067,-0.033136178,0.013090488,-0.02965295,0.004568515,0.025201246,0.026761035,0.035068583,0.002491971,-0.026611345,-0.028514037,-0.07162069,-0.038934413,-0.03178079,0.061939973,0.04701639,-0.08032742,-0.054678235,0.05189177,0.061339494,0.062009305,0.042427137,0.021602191,0.010428382,-0.013977672,-0.036838386,0.079133764,-0.111861095,0.016874557,-0.02898552,-0.07461061,-0.08101656,0.007892545,-0.02797448,-0.0048751715,0.020585796,-0.01610986,-0.013890713,0.0949229,0.032837726,0.015009116,-0.0714067,0.0075279376,-0.00027829307,-0.03614551,-0.035951663,0.05154047,0.06226272,0.03449807,-0.00850231,-0.0022460674,-0.085944556,0.01122313,0.01872008,-0.050060537,0.04149552,-0.001955303,0.054831054,0.120953046,-0.028173955,-0.0314923,0.03893555,-0.0014909469,-0.07441898,-0.026609922,0.053828582,0.03524949,0.11516417,0.045636967,-0.005429332,-0.016709605,-0.011421053,0.016955381,0.05442073,-0.05174124,0.10045977,0.020937512,-0.1090303,-0.042015515,-0.01590694,0.08413736,-0.021933982,0.058063123,0.0817564,-0.01963968,0.050181236,-0.07501036,1.4229123e-33,0.06368218,0.07780963,0.092999086,-0.046028197,0.006097669,0.021362336,-0.09158623,-0.0027068658,-0.022839788,-0.0016294231,-0.065534204,-0.032018367,0.026765691,0.05692083,-0.026063511,-0.01481207,-0.026397504,-0.02839617,0.06276901,-0.0059506767,-0.055586215,0.036461458,-0.026630655,0.0379196,0.05198218,0.081515975,-0.038302805,-0.010207112,0.052127756,0.014328337,0.021132162,-0.13006184,-0.07385862,0.047708195,-0.020439044,-0.03957024,-0.038304538,-0.051188454,0.021163503,0.044944108,0.03432944,0.024195421,0.010555704,-0.05229394,0.027407033,-0.012362261,-0.038507838,0.06795356,0.086740725,0.06599514,0.009775801,-0.047183637,0.043785606,0.0035567211,-0.012064665,0.045799717,-0.069068335,-0.010080778,0.05191415,0.071788095,0.039099395,0.1123973,-0.0076948637,-0.032937996,0.053133257,0.06536839,-0.003105358,-0.08803961,-0.06946491,-0.031184424,-0.06654129,-0.026675453,0.078807384,-0.038856868,-0.014473314,-0.061087966,-0.039209157,0.0009788813,-0.015088507,-0.0066378484,-0.08498102,0.061778132,-0.003709602,-0.01573029,0.0056664655,0.01827575,-0.07500777,-0.038568385,0.03514931,0.08239561,-0.03342828,-0.022015074,-0.06364669,0.018237451,0.029962406,-2.863121e-33,0.087249376,-0.10243474,-0.0101058,-0.033922277,-0.054410856,0.0010888682,0.021789033,-0.0113594355,0.09119819,0.01805454,0.053997543,-0.04015225,0.0561312,-0.06503576,0.03638436,-0.043894555,-0.0075545893,0.07134805,-0.013675791,-0.004894396,0.04753436,0.05138418,0.01280063,0.043935858,0.07968907,0.0038357957,0.041728947,0.036162846,0.033003666,0.015308435,-0.029593283,-0.03803519,-0.038031727,-0.07992871,-0.04041067,-0.029711926,-0.052502297,0.06420671,0.016919712,-0.0426641,0.018915715,0.083838776,0.020991238,0.064053394,0.054141108,0.11612311,-0.026565127,0.027952142,0.012261582,-0.046371102,-0.011289421,-0.0042236913,-0.02900324,0.029007796,0.01612605,0.06430122,0.021406801,-0.012665257,0.027125474,-0.035288613,-0.032276563,-0.055678822,0.09154802,-0.109743334,0.06683383,0.022613537,-0.12749502,0.01592849,0.0145836575,0.036587697,0.06302791,-0.06035932,-0.08417402,0.06923517,-0.020472268,0.0066006463,-0.12895778,-0.10839617,0.0021830245,-0.06698746,0.06575989,0.019829383,0.031861797,-0.058286283,0.032685496,-0.06283564,0.023178838,0.16269411,0.02064439,0.044489592,-0.072010055,-0.036613837,-0.05684848,0.04508948,0.0431847,-4.2155097e-08,-0.009133256,-0.0008227337,0.030773077,-0.055769786,0.009574077,0.07979848,-0.015202709,0.04856751,0.03214409,-0.07855813,-0.036339335,0.093700975,0.03849958,-0.008166453,-0.007326912,0.059647914,-0.045523398,-0.010890315,-0.01129334,-0.017785221,-0.053173844,-0.054125153,-0.060272038,0.004002007,-0.013149644,-0.08891848,0.060911283,0.10557451,-0.06910354,-0.10241211,0.026235636,0.059629478,-0.023235472,-0.014091796,-0.039198168,-0.023486262,-0.060623787,-0.01951811,0.06373387,0.0360536,-0.053756446,-0.016464943,-0.010776878,0.00792276,-0.053387463,0.041772842,0.026461797,-0.06318688,-0.014466454,0.03293975,-0.005007581,-0.05378145,-0.06775971,-0.03394981,-0.05973364,-0.010405413,-0.030448932,-0.08000518,0.043268092,-0.016475054,0.04171321,-0.012394507,0.1452962,-0.005186903 +2.4.1.91,"Acts on a variety of flavonols, including quercetin and quercetin 7-O-glucoside. Different from EC 2.4.1.81 (flavone 7-O-beta-glucosyltransferase).",384,0.9999999,-0.081750385,-0.08828932,-0.07060435,0.078010164,0.059297744,0.03632258,0.027768934,0.03721888,0.090881534,-0.09728234,0.018528847,0.04947811,-0.1321175,0.0038844943,-0.07437564,-0.03819433,0.015396753,0.034918386,-0.07093018,-0.044253446,0.038166188,-0.022540472,0.06538857,0.0014414575,0.036114495,-0.027237423,-0.028366437,0.017334826,0.0042053405,-0.121574946,0.042012427,-0.0024685988,0.003182426,0.007266876,-0.060558327,-0.025016373,-0.006844068,-0.06558325,-0.020057807,0.002240544,0.066531405,-0.059671156,0.014243923,-0.003479852,0.050868157,-0.09198513,-0.055177387,0.026149873,-0.0105567025,0.057003975,-0.013928128,-0.033694383,-0.09701689,0.046948098,0.01907492,-0.006949506,-0.07229431,-0.023255482,0.02289956,0.08177443,0.030466815,0.015381773,0.029168084,0.032523777,-0.11676761,-0.034945294,0.06646178,-0.034007195,0.016590057,-0.06491917,-0.052481588,-0.033630054,-0.013052231,0.02123064,0.07265375,0.090928905,-0.06954368,0.011985899,-0.046419345,-0.030564368,0.07930084,-0.06493374,-0.0089150425,0.056706093,0.001262613,-0.030733738,-0.05688042,0.02622294,0.039272934,0.09101957,0.054572295,0.038811106,0.026985615,0.014963412,-0.009664081,0.07927301,0.06614183,0.043887895,0.0007019784,0.015165059,-0.03245172,-0.031331256,0.0054274974,-0.02115531,-0.01966071,-0.00279105,0.052742064,-0.019107869,0.0601671,-0.10006211,-0.0020020455,-0.09165254,0.012755944,-0.081592016,-0.035333402,-0.01368795,0.003701496,-0.021058654,-0.008038227,-0.024458729,0.0014363042,0.06445738,0.05868225,0.03698889,-0.028158892,0.032630187,-0.06541872,1.9172179e-33,0.08821037,0.029837422,0.036083084,-0.0042913407,-0.00917168,-0.04623772,-0.043786276,0.027183574,-0.0048471726,-0.028329499,-0.10412748,-0.040622395,-0.028705314,0.018714927,0.06815145,0.043294676,0.025000082,-0.10034901,0.047461666,-0.022722306,0.05201048,0.0674257,-0.105303176,0.07850836,0.04596582,0.02715421,-0.057001047,0.07111342,-0.02213768,-0.010253532,-0.06437384,-0.07916962,0.029114114,0.03220322,0.013684858,0.046083268,-0.051046323,-0.059021324,-0.003561068,-0.0046028784,-0.00016917498,0.004359015,-0.0075909817,-0.0073169763,0.0013998852,-0.014743066,-0.06218636,0.056198902,0.08392018,0.03928073,0.039943445,-0.036057204,0.09465768,0.09593188,1.0866214e-05,0.059756614,-0.048924528,0.03917658,0.08920426,0.036695782,0.012579171,0.022679867,-0.008101177,-0.059206255,-0.03652275,0.076842904,-0.0744407,-0.01485395,-0.05680008,0.014566715,0.026282912,-0.0033431223,0.07213307,-0.006988191,0.17595112,0.0028859575,-0.07763755,0.00060636975,0.015666345,0.033960573,-0.058160264,0.0037320463,-0.02078971,0.057122383,-0.109718025,0.052603506,0.024236718,0.0148940645,0.086109586,0.05718283,-0.031170102,-0.05335019,-0.03267933,-0.0021601093,0.067268714,-1.8972984e-33,0.031292427,-0.03617247,0.023808287,0.06147297,-0.019846994,0.021517005,-0.027853034,-0.07086296,-0.0009574059,-0.0014767995,0.03774201,-0.072165154,0.057200156,-0.07988004,-0.0012596181,-0.03280547,-0.043701254,0.06804701,0.020109953,0.05264154,-0.07037679,-0.007189945,-0.00536575,0.043955863,0.08450635,-0.04058556,0.07303346,-0.030174129,0.026947312,0.041902397,-0.070434034,-0.015378244,-0.026042264,-0.023947205,-0.06078104,0.027634544,0.028688738,0.0046426863,-0.054749724,-0.055125132,0.010048827,-0.04553847,0.05104994,0.07289579,0.06782539,0.123278715,0.008341778,0.040842358,-0.009299494,-0.016547538,0.044597704,0.11066961,-0.0460016,0.063836366,0.0594475,0.018023707,0.07698103,-0.014214922,0.021216972,-0.03135504,-0.005981522,-0.08258844,0.016004713,-0.039763104,0.1181582,0.05429114,-0.037126455,0.092130065,0.0020362418,-0.030432483,0.052074026,-0.17043217,-0.0051612486,0.058318704,0.025874414,-0.069798656,-0.016188478,0.0016429711,-0.033446107,-0.011566069,0.03147593,-0.05157342,-0.006595146,-0.06319976,-0.018439703,0.0054382347,0.029656041,0.045428567,-0.012054786,0.07182878,-0.04587721,0.014761414,-0.07393269,0.018371789,-0.0195124,-3.1892178e-08,-0.020085882,-0.012913702,0.0695146,-0.015100672,0.046825174,-0.0032091697,-0.033559572,0.055219296,-0.029079884,0.03906967,-0.014820912,0.07260825,0.040387813,-0.0021628104,0.006581733,-0.005014965,0.017541692,0.045874152,0.018043615,-0.018713353,-0.07991915,-0.01127795,-0.09286445,-0.050162684,-0.05536639,-0.08708644,-0.0008800546,0.08263954,0.069555186,-0.10700286,0.043560423,0.028730517,0.024439538,-0.057004243,-0.119284324,-0.027850961,-0.0093554575,-0.027610864,0.031282406,0.03875646,-0.09046897,-0.007075309,-0.01588786,0.02757813,-0.024231566,-0.024055699,0.046564326,0.010131085,0.023747075,-0.0022048957,0.019212084,-0.045734834,-0.01884267,-0.052871585,-0.0074958564,-0.0297982,0.082081065,-0.0045950264,0.0579645,-0.0797628,-0.022692168,-0.05853045,0.11099514,0.035973042 +2.4.1.92,"This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. Asialo-GM3 [3] and lactosylceramide [2] are also substrates, but glycoproteins and oligosaccharides are not substrates.",384,0.99999994,-0.028202606,-0.10147013,-0.06174492,0.012036304,0.024654942,-0.014350872,-0.037375063,-0.011297187,-0.02526165,0.022017453,0.01165909,0.014280428,-0.07861878,-0.05987237,-0.0034939845,0.02202076,0.02697738,0.0031768302,0.021145849,-0.061926845,0.05328896,-0.07951388,0.0074906386,0.0028477262,0.038001034,0.04094124,-0.013735226,-0.05421929,0.0018838966,-0.03344504,0.012462178,-0.09304219,0.03783839,0.0030596906,0.036561005,0.01943604,-0.034734305,0.04287151,0.018917846,-0.028767608,0.041208584,-0.07382543,0.025933227,-0.035178315,-0.03820772,-0.0699468,-0.03776954,0.041071955,0.018160515,-0.004313292,-0.06137551,-0.0850173,-0.041581117,-0.0068227523,-0.0007434579,0.0488663,-0.07843497,-0.002765283,0.039107148,0.07466882,-0.0060845586,0.02841087,-0.0030017542,-0.0010921312,-0.03146273,-0.057779953,0.025430292,-0.04030698,0.008851831,0.084140904,0.012947562,-0.019674696,-0.0644154,-0.053540792,0.0033111698,0.07121836,0.016468408,-0.004454428,0.10486664,-0.07080785,0.03643427,0.06386819,0.1079377,0.08694963,-0.04009703,0.011478516,0.023607412,0.05228353,0.015097509,0.0133091435,0.03368912,0.0030564943,-0.031111844,-0.013600298,-0.08474078,-0.00041768176,0.016180957,-0.038035303,0.069135144,-0.034148578,-0.021305872,0.019220365,0.009396179,-0.08712995,-0.09247627,0.11833691,-0.062966816,0.031191217,0.07053488,0.028569723,-0.039296042,0.08127663,-0.0018596657,0.036449205,-0.05833555,0.030932099,0.009631217,-0.042387173,-0.01026341,-0.034852248,0.0061170347,0.008032145,0.03075504,0.011575591,-0.06536864,0.074177854,-0.02252199,1.721545e-33,0.06634851,0.004978855,0.023187282,-0.07503801,-0.051825047,-0.009026669,-0.06479938,-0.0056144656,-0.046448454,0.037939876,-0.038535524,-0.07505848,-0.0037742122,0.10074005,0.048457094,0.057455327,0.048525084,-0.048713166,0.08054441,-0.0525662,-0.050939556,0.054820262,-0.02223861,-0.052743718,0.069970235,0.091703415,-0.05404714,0.044210125,0.06759803,0.01992835,0.04238434,-0.04331903,-0.08079478,0.016912816,0.0006370983,0.060607832,-0.066337556,-0.04657356,0.01024824,0.058455758,-0.0019540947,0.013793821,-0.009525488,-0.07640729,-0.022659693,0.013597245,-0.033085786,0.018938012,0.051242806,0.02427742,-0.01863471,-0.0037744178,0.062459785,0.058557242,0.0054831854,0.077647135,-0.025548156,-0.04128837,0.014834372,0.037436616,0.014608372,0.026287252,-0.0032759802,-0.0039451295,-0.005563682,0.043894075,-0.054029144,-0.01814137,-0.08219302,-0.022483002,0.01701344,-0.01721807,0.018803556,0.051870525,-0.02641671,-0.063142665,0.03632872,-0.03764544,-0.013917802,0.013497611,-0.05354412,-0.009357502,-0.0307052,-0.016024243,-0.046200454,0.053595807,-0.07122575,-0.06880642,0.011270764,0.027823625,-0.113825925,-0.075311534,-0.03832721,0.10589417,-0.085568614,-5.073237e-33,0.05702127,-0.054205827,0.081864856,-0.07569212,-0.084410556,0.058183037,0.0087233465,-0.023631927,0.011965709,0.0691613,-0.026370572,0.033962622,-0.0060207704,-0.09700626,0.014347085,-0.06368353,-0.016554916,0.08738305,-0.018282661,-0.0058900137,0.016823059,0.12446728,0.00064692256,0.041778687,0.08089143,-0.04314832,0.0071606846,0.04880176,0.010853053,0.084045455,0.04215972,0.042570796,-0.036515344,-0.09405188,-0.013567569,-7.345608e-05,-0.029194005,-0.036896203,0.03869461,0.00730404,-0.015828243,0.08267498,0.07709996,0.05914994,0.06304653,0.09723873,-0.051377036,0.04160279,-0.051746488,-0.0613935,-0.010699936,-0.0075302436,-0.018314797,0.046645235,0.061267916,0.07854818,0.046425745,0.0001618106,-0.01998104,-0.11454381,-0.07681966,-0.043722145,-0.00092816335,-0.07413711,0.092575155,0.09125216,0.01817394,0.027998328,0.039520126,0.0020672986,0.045673132,-0.015384676,-0.060774617,0.08341235,0.01404317,0.037925165,-0.1348726,-0.023853034,-0.005642802,-0.028618582,0.13863465,0.0040406943,0.045294013,-0.0140802665,0.016840504,-0.028576273,0.032324508,0.13201527,0.0149456095,0.074551456,-0.05947547,-0.0053014103,-0.03130806,0.10690595,0.03822955,-3.8859195e-08,0.06716605,-0.08191145,0.025515364,-0.095038794,-0.124847665,0.015997007,-0.00580207,0.024701836,0.03442856,-0.02485527,-0.059040297,0.07582059,0.027909646,-0.013829665,-0.09567068,0.04254231,-0.0067779724,-0.0342795,-0.027022108,-0.008483953,-0.107268564,0.0060443976,-0.059625372,0.059660226,0.0027467327,-0.115873486,0.045442883,0.036510896,-0.091122314,0.0103759095,-0.033969376,0.05253091,0.011517847,-0.03239583,0.007934156,0.003930848,0.0053700423,-0.088038646,0.09134062,-0.05014821,-0.0042538703,-0.0045220056,0.009084962,-0.03280274,-0.020334642,-0.0021091262,-0.023764754,0.025575586,-0.043840323,0.022628823,-0.07897374,-0.029112142,-0.052301623,-0.049131572,-0.07509768,-0.06218631,-0.06786806,-0.008137462,0.022777481,-0.071414374,0.030769337,0.025232181,0.12273899,-0.039054647 +2.4.1.94,The acceptor is the asparagine residue in a sequence of the form Asn-Xaa-Thr or Asn-Xaa-Ser.,384,1.0,-0.11934118,0.041612014,-0.06060239,-0.017534096,0.0435563,-0.038174335,0.11420383,0.028371396,0.03559659,-0.034660105,0.13509226,-0.009329399,-0.03989702,-0.0042322576,-0.093840964,-0.027305355,-0.04256619,-0.06876334,-0.022937734,0.01634604,0.018119248,0.122284755,-0.027547313,0.0066036186,0.017926794,0.018139184,-0.028801352,-0.05317158,0.1289814,-0.07527783,0.029989613,0.016353583,0.08643277,0.043197613,0.01186832,0.046583325,0.0016875801,-0.07259169,0.031997982,-0.0009549549,0.049878057,-0.016970087,0.037487548,-0.025348064,-0.044480287,-0.017212052,0.019552844,0.03735431,0.03768358,0.011508297,0.07784354,0.030635495,-0.06780542,0.050337665,-0.045903787,0.031180458,-0.10086866,-0.09043541,-0.083702736,-0.017122336,-0.06599344,-0.0031751757,-0.060490415,-0.0054464713,0.06614723,-0.041537866,0.062365294,-0.13079429,-0.0108766975,0.011547494,-0.018448777,-0.01785165,-0.012314268,-0.015016978,0.024045466,0.025724519,-0.032776866,0.025551198,0.03055618,0.0003657721,0.035348754,-0.02234932,0.04310155,0.00996156,0.014032334,0.012326962,-0.07500995,0.030535104,0.07441221,0.1138736,-0.009910285,-0.06149969,0.011428499,-0.054634094,0.042202566,0.028427416,0.098278046,0.043337148,0.05917521,0.050886102,0.0037553678,0.020970708,-0.08811351,-0.048048608,-0.074449,-0.029670894,-0.029001638,-0.0354857,0.018758893,-0.00582,-0.027733069,-0.12428935,0.0991391,-0.0074079577,-0.06621757,0.023939632,0.0032130769,-0.070435375,0.030106785,-0.09871071,-0.015873563,0.0007367762,-0.058189344,0.066710725,-0.029011993,0.0043422445,-0.07961921,-1.2233757e-33,-0.040271226,0.096811324,0.04345209,-0.08669765,-0.081227005,0.04090025,-0.006677953,0.0027137462,-0.045304928,-0.052496474,-0.06356192,-0.06732978,-0.00042475964,-0.016912963,-0.006928182,-0.072336785,0.006039165,0.09702262,0.011919359,-0.03257152,0.06733159,0.048684858,-0.04054268,0.056934293,-0.03544997,0.032640174,-0.056946915,-0.0074631735,0.03673499,-0.0061541335,0.10134699,0.023484936,-0.031212335,0.006889575,0.03387163,-0.012182233,0.05653039,-0.0011320144,-0.0045556845,-0.05376513,-0.016860886,0.005979381,-0.08854106,0.07795232,-0.014352532,-0.06553779,0.01815265,-0.02022657,0.05954317,0.017489899,-0.0526101,-0.008707167,-0.0366706,-0.055036265,0.010545708,-0.010504151,-0.026141867,0.065891646,-0.039915778,0.03772081,0.039547134,0.017043123,-0.04756686,0.020252874,-0.0202407,-0.0051859855,0.0021867014,-0.063611336,0.057889435,0.059170596,-0.063379325,-0.018517219,0.037036907,0.07430035,0.05805078,-0.013842317,-0.083296016,0.04841473,-0.00057807076,-0.024061235,-0.13161013,0.03940226,-0.031684432,0.06338057,-0.07469672,0.009081265,0.08322451,-0.024206702,0.04856075,-0.07425655,0.039970584,-0.0467423,-0.05508405,-0.017695814,0.043786176,-1.1160109e-33,0.06432983,-0.05189884,-0.0017309211,0.08426579,-0.029505026,0.032503083,0.053082243,0.021906996,0.091646254,-0.046148412,0.057720535,0.08221037,0.03228538,-0.00884867,0.06953097,-0.0330339,-0.054142028,0.1276809,-0.03364952,0.026953526,0.03215603,-0.017165998,0.031950556,-0.002216015,-0.03251794,0.009763513,-0.018835913,-0.018262163,0.0025001834,0.062143862,-0.040873144,0.023601864,-0.019384494,-0.04606533,-0.037180852,-0.06486122,-0.009266425,0.011205804,-0.101684235,0.011072992,0.045921624,0.011329746,0.046425693,0.077440426,-0.02431407,-0.03869466,-0.00023572953,0.043562446,-0.000612782,-0.05783646,0.0179667,0.036251854,0.019713193,-0.008780108,0.051942255,0.11383294,0.026053779,-0.020768842,0.0015996908,0.038727466,0.014338054,0.0015872784,0.055124946,-0.0133727165,0.013819448,-0.070068434,0.011861044,0.006970095,0.0567181,-0.044838578,0.0627561,-0.041241817,0.033067595,0.058780853,0.09260539,-0.109801844,-0.02069037,-0.025921246,0.021205783,-0.038527075,-0.13054398,0.035974674,-0.0014304677,0.0010888135,0.013538441,-0.03671087,0.061892807,0.02529856,-0.052381016,0.01857128,0.0019928871,0.014795092,0.031055229,0.0773228,0.03757161,-3.301387e-08,-0.06878737,-0.046645332,-0.028770128,-0.11288329,0.06275459,0.06889633,-0.02971176,-0.044728074,-0.03074066,-0.079425044,0.10421489,0.026187303,-0.014462507,-0.08440915,0.06815931,0.021621332,-0.0405623,0.020978225,-0.063431524,-0.009792237,-0.057413626,0.030535603,0.013834869,-0.120466806,-0.004163004,0.03544218,-0.012057743,0.12085061,-0.03719599,-0.0010037207,-0.00036292727,0.004589757,0.036709774,-0.05032802,-0.014295061,0.08229291,0.030461691,-0.08733194,0.054975655,0.060647942,0.03639856,-0.065917715,-0.012147016,0.0045168907,-0.0007035432,0.08774682,0.026625687,-0.025189625,-0.099366136,-0.006641008,-0.0012762647,-0.021751735,-0.01961872,-0.01699994,-0.03514234,-0.015655052,-0.03499859,-0.06791189,0.013318502,-0.026804242,0.07662463,0.0653014,0.073915064,0.008199413 +2.4.1.96,"The product is hydrolysed by a phosphatase to isofloridoside, which is involved in osmoregulation (cf. EC 2.4.1.137 sn-glycerol-3-phosphate 2-alpha-galactosyltransferase).",384,1.0,-0.0047294707,-0.07535902,-0.11502952,0.038892508,0.05631069,-0.008436153,0.013993904,0.057704642,-0.007280923,-0.04380134,0.045882247,-0.0062062154,-0.04055454,0.020670818,-0.09711203,-0.0554351,-0.017339708,0.012263346,-0.04279038,-0.027521368,0.12762944,0.025484638,0.01053345,0.07017495,0.049074322,-0.025610879,-0.02043393,-0.04981848,-0.004158957,-0.03125401,0.039116412,-0.051982053,0.107059754,-0.1168326,0.032649044,0.057837415,-0.013829968,-0.048929755,-0.080317184,0.0056443005,0.044602174,-0.09886769,0.014287978,-0.019505156,0.03444542,-0.0014491478,-0.03959583,0.065261655,0.021254594,0.0750368,-0.010911028,-0.094482005,-0.058954608,0.024696719,-0.00878802,0.063659154,-0.06947988,-0.04415589,-0.025942821,0.025473023,-0.0016259626,0.03266457,0.0020181458,0.06523318,0.04714715,-0.0448239,0.033559814,-0.09729546,-0.036392186,0.002536207,-0.0047158017,-0.05908484,0.015929911,-0.019038163,-0.032937754,0.06132973,-0.007884924,-0.011509631,0.05621602,0.0010752772,0.08065625,-0.026869748,0.011470503,0.06708365,-0.0019015857,-0.015345354,-0.026099684,0.012178635,-0.047407333,0.055471547,-0.014791072,-0.014206158,0.020898987,0.001901592,-0.029635655,0.057798278,-0.02047624,0.01714957,0.015006116,0.026003253,-0.08924819,0.015588671,0.018718822,-0.08082914,-0.036234,0.033220444,-0.091089256,0.06291656,0.031351652,0.067452095,-0.019584674,0.010569061,0.038890827,0.060553532,0.027027318,0.08152179,0.012181021,-0.017600283,-0.08330809,0.011153328,0.016158465,-0.06430375,-0.005059858,-0.00046176816,0.0081905015,0.028643353,-0.00063284405,1.19564875e-33,0.058418527,-0.012821297,0.04293118,-0.040969603,-0.046595555,-0.025908345,-0.05946931,-0.07667594,-0.05929968,-0.01268366,-0.02110146,0.021513898,0.021944428,0.0630024,0.026540972,-0.021418286,0.052184053,0.030589936,0.101387955,-0.037972208,0.028902525,0.06216369,-0.044529784,-0.01664505,0.019470131,0.018226344,-0.051268317,-0.018960042,0.06791725,0.048155244,0.04016061,-0.09323111,-0.06801788,-0.05380893,0.018381283,-0.054249913,-0.06448204,-0.12625839,-0.00024072354,0.056951992,0.034915544,-0.016834047,-0.005353386,-0.013184117,0.013273391,-0.008198284,-0.055797093,0.10622831,0.108134545,0.04963598,0.0082123345,-0.0018163956,0.025591217,-0.01392279,-0.015390606,0.026952354,-0.059112333,-0.06409655,-0.023773918,0.019671833,-0.012445907,0.09899786,-0.008771677,0.013858854,0.014880178,-0.004713923,-0.028159508,-0.026341746,-0.063025005,-0.038308803,-0.025035111,-0.037511293,0.06765473,0.07397098,-0.058818124,-0.05111718,0.08693161,0.0833456,-0.049313728,0.010726823,0.010460073,0.020164557,-0.02358624,0.015953965,-0.0031050926,0.0021889065,-0.06068643,-0.04964122,0.009212767,-0.01269004,-0.0052831103,-0.024464225,-0.053611767,0.053152055,-0.047138426,-2.1845865e-33,0.058882326,-0.09423862,0.04381498,-0.07138924,-0.015947279,0.07470563,-0.019442236,6.459761e-05,0.06767228,-0.019431876,-0.04379891,0.00545331,0.009836107,-0.13346532,-0.005323986,0.003284275,0.09383638,0.07471034,-0.059829842,-0.02860715,0.054199353,0.084280536,0.021053324,0.061649546,0.046185274,-0.020857204,0.019593429,0.057973515,-0.022086937,0.1034065,0.029269435,-0.014676695,-0.051611766,-0.13636586,-0.07359436,-0.0064689317,-0.014388301,-0.011987384,-0.042410374,-0.06532662,0.01373073,0.041035604,0.10176465,-0.045918524,0.089630134,0.11563253,-0.049732316,-0.03117255,0.0051029255,-0.018520268,0.006076412,0.01063162,-0.023853714,0.13507465,0.06566605,0.037965603,0.041967552,0.023868969,-0.027460784,-0.079136446,0.031333547,-0.048321176,0.034008108,-0.067568004,0.049638454,0.048433665,0.0010342612,-0.020099567,-0.019803876,0.017703077,0.031258684,-0.057421148,0.014786515,0.10249014,-0.012230224,0.02261073,-0.082208194,-0.057251144,-0.038688477,-0.06094313,0.034561533,0.03176401,0.024162335,-0.04435641,0.0015627318,-0.10279422,0.058381468,0.07243455,0.004152379,0.025411984,-0.062481057,-0.027430786,-0.07822923,0.007018616,0.10157129,-3.624806e-08,0.025765346,-0.06398153,0.04750719,-0.07804925,-0.024977604,0.06315103,0.06947387,0.04214789,-0.005344195,-0.11230076,-0.018138113,0.072661094,0.06348761,-0.037866052,0.037893057,0.057838213,0.034486752,0.038944144,-0.032879535,-0.05563048,-0.05464936,-0.008248702,0.04619447,-0.0037104832,-0.029372804,-0.006767339,0.077548265,0.074234724,-0.032378968,-0.024198517,0.0251378,0.005010448,-0.008496768,-0.012581083,-0.06872221,0.033764433,0.0014180775,-0.010880083,-0.0110459365,0.066056356,-0.080313124,0.008006841,0.021660974,0.048140787,0.019754048,0.03809042,0.005290064,0.09459823,-0.039704427,0.00382242,0.009426962,-0.066798344,-0.107500814,-0.081807025,-0.10096395,-0.027029367,0.037386388,-0.07270996,0.012171624,-0.015056189,0.03045201,-0.014713116,0.19317903,0.0013845355 +2.4.1.97,"Acts on a range of beta-1,3-oligoglucans, and on glucans of laminarin type. Different from EC 2.4.1.30 (1,3-beta-oligoglucan phosphorylase) and EC 2.4.1.31 (laminaribiose phosphorylase).",384,1.0,-0.07446075,-0.13028148,-0.073452964,-0.03390697,0.035132386,0.038992457,-0.009358116,-0.03264444,0.10375267,-0.056695692,0.04913632,0.01542932,-0.13926288,0.04694769,-0.08867478,-0.008963242,-0.05865755,-0.02743753,-0.046300568,-0.0052443976,0.041607127,0.024809014,0.038835395,0.069429256,0.009328616,-0.047040485,0.02377085,-0.019292653,-0.01550313,-0.066414885,0.0636023,-0.06544484,0.039325103,0.023719328,0.09999178,0.008722097,-0.07256075,-0.08191559,-0.028555067,-0.0038664935,0.11290611,-0.044136487,0.010767862,-0.007718718,0.009291532,-0.055568244,-0.028091833,0.029991522,0.049024366,0.024252772,-0.028926233,-0.08010929,-0.07315965,0.016866887,0.03378131,0.09467394,-0.10280518,0.0009096063,0.06054772,0.08733365,-0.044799,-0.0013829478,-0.049277823,0.049691483,-0.033110328,0.00978526,0.07316552,-0.09189265,-0.03395049,0.029672602,-0.033488933,-0.013782983,0.007224095,0.014516082,0.06459319,0.034184404,-0.0119569665,-0.030026985,-0.01955865,-0.042846788,0.026124308,-0.030861422,0.059336662,0.031399336,-0.06446945,-0.031298906,-0.03551237,0.0053000445,0.0317689,0.020225838,0.06293029,-0.031095505,0.026346125,-0.02654878,-0.021429967,-0.0018670455,0.048522644,0.035606515,0.066313244,-0.02445951,-0.05126231,0.0035103557,0.022143945,-0.05691096,-0.018130708,0.09860265,0.021945111,0.070745945,0.012114336,-0.006351141,0.008690648,-0.07513187,0.029339232,-0.041739184,-0.060609963,-0.0058198944,0.069917634,-0.09522788,-0.018071426,-0.01753564,0.028921409,-0.08167443,0.08812928,0.015340362,-0.1603147,0.114891335,-0.11751747,1.1317234e-33,0.081084415,-0.042746417,0.014475386,-0.03501895,-0.006853267,0.008709863,-0.06917201,-0.07160499,-0.039973136,-0.09089367,-0.0076213917,0.01912475,-0.020526638,0.12699778,0.088685475,0.09250973,-0.012125272,-0.020381,0.044703223,0.011069194,0.0401268,0.10280167,-0.023856828,-0.032101706,0.084327586,-0.0108014885,-0.09879665,0.033160515,0.024705531,0.006567503,0.08329178,-0.03983586,-0.10720405,0.027705044,0.039289404,0.121699624,-0.017804114,-0.03661571,0.0314751,0.007263201,-0.022018945,-0.016285062,-0.0021629522,-0.030783784,0.095869854,-0.069525555,0.01624169,0.027680954,-0.022186413,0.062011834,0.014678314,-0.010514105,0.095907606,-0.009024994,0.055143144,0.013512216,0.0062035252,0.026888885,0.05475941,0.038073264,0.013619598,0.061079256,-0.020796254,-0.032060623,0.0065752366,0.05448918,-0.08928824,-0.016404603,-0.044314824,-0.0017063804,-0.0017253443,0.012301739,0.038409222,-0.025946213,0.031254437,-0.031009834,-0.05656727,-0.00786758,-0.057881717,0.022042854,-0.008429344,0.017624682,0.04295186,0.045916647,-0.08975501,0.07317727,0.029846396,0.00032981744,0.0023580384,0.074757576,0.016273862,-0.01907399,-0.04796943,0.10025725,-0.010954351,-2.6892982e-33,0.09756789,-0.06573456,0.020564284,0.013630388,-0.059168566,0.038743995,0.071741626,-0.017406693,0.025199007,-0.047692884,0.042209715,0.017628752,-0.035343643,-0.054503288,0.026864018,-0.050313618,-0.07390826,0.030731319,-9.289222e-05,-0.0071437405,-0.021316178,0.043504797,0.03666789,0.08458026,0.09549721,-0.03610806,0.04575622,0.03114144,-0.037423152,-0.010614298,-0.122887954,0.01395519,-0.0005440772,-0.011598769,-0.012699737,0.04182563,0.010532922,-0.022925733,0.020656878,-0.025252182,0.035651382,0.027934456,0.025400676,-0.000845767,0.011531815,0.14340101,0.030143853,0.059988484,-0.08751021,-0.034626327,-0.035944838,0.01781732,-0.036609028,0.06126318,0.07476888,-0.0008894328,0.11349611,0.026607359,-0.0049008094,-0.056470532,-0.07713183,-0.017430807,0.033208158,-0.04126557,0.11523673,0.05761531,-0.007254719,0.042676806,0.010673711,0.0050490177,0.0023827758,-0.053091936,0.04892282,0.0034264768,-0.0087924125,-0.012071735,-0.10637654,-0.05536648,0.012091163,-0.034945164,0.017711895,0.0083334735,0.01504706,0.010443919,0.032405395,0.020022104,0.058988392,0.062272787,-0.035841685,0.023281878,0.026007691,-0.011598401,-0.044427674,0.008039769,0.01713982,-3.5418136e-08,0.044824857,0.04778905,0.008608811,-0.11105636,0.020938624,-0.0008224064,0.054653868,0.049725458,0.021867055,0.05406244,-0.013253612,0.06405944,0.05555811,-0.0043779705,0.0032718005,-0.021245249,-0.07639727,-0.03632633,-0.0033538144,-0.043184347,-0.076652765,0.018918324,-0.062057804,0.0480154,-0.06773422,-0.14285788,-0.024018502,0.06788348,-0.04239243,-0.002795664,-0.033741202,0.015605247,-0.015111363,-0.06484055,0.017446056,0.008214768,-0.06333105,-0.034657095,0.00064296834,0.0447035,-0.032952446,-0.053670913,-0.0028938705,-0.04459238,-0.038651854,-0.019606106,0.059217233,0.0041495273,-0.02695042,-0.017036576,0.03186676,-0.08182699,-0.022810591,-0.036291067,-0.10154069,-0.07790022,-0.019485159,-0.076929666,0.019603752,-0.032894537,0.041554477,-0.0015464391,0.07350787,-0.014502423 +2.4.1.99,"For definition of the prime in the systematic name, see 2-Carb-36.2.",384,1.0,-0.0039598383,-0.03626791,-0.06388291,0.0021755272,-0.003453896,-0.029113587,-0.060152333,0.11399107,-0.051188476,-0.03790769,0.010822684,-0.04195796,-0.016456023,-0.06925163,-0.0049116276,-0.00459883,2.5103202e-05,-0.03588015,0.0019067856,0.0012965136,0.050109293,0.017239852,0.027374119,0.018906169,-0.010817159,-0.03926891,-0.043332435,0.008087269,0.046967827,-0.0621801,0.07400983,0.043527614,0.09406652,0.0024987806,0.09638765,-0.110050075,-0.085625164,0.05011798,0.01781822,-0.0011964453,0.1333674,-0.054440096,-0.054012667,0.046939954,-0.043771964,0.024006499,0.021805804,0.086280644,-0.026263585,0.0073697786,-0.04823119,-0.09409933,-0.14987987,0.039342802,-0.004565083,-0.035209402,-0.016316151,-0.0028119066,-0.040354557,-0.001166895,-0.023078201,0.08590525,0.007363162,0.0085343355,0.077528134,0.024515623,-0.008525408,-0.080768086,-0.011838512,-0.017399624,-0.019273419,-0.02874808,0.07765847,0.030714642,0.02739119,-0.051404458,-0.046263527,0.021943256,-0.037844464,-0.04840808,-0.021179445,-0.0073759058,0.018760476,-0.019445186,0.04260688,0.01694229,0.013754346,-0.0603278,-0.007018331,-0.054098338,0.010725492,-0.066578135,0.027008718,0.014244845,0.019328453,0.017106097,0.13902798,0.014405895,0.06524443,-0.037834678,0.01412584,0.04959199,-0.09311736,-0.02106781,-0.103714414,0.042926256,-0.019013226,0.07590343,0.050796878,-0.0018546567,-0.005108466,0.014046923,0.0009207607,-0.1092599,-0.048031256,-0.024788821,-0.05294189,-0.011452929,0.112475395,-0.078357555,0.04561704,0.035452835,-0.015153739,-0.02771055,-0.06594324,0.035585206,-0.1078851,-1.9529893e-33,0.0076567368,0.05328373,0.05305405,-0.01563191,-0.0688653,-0.036657963,-0.03462773,-0.03937794,-0.06402049,0.028119832,0.0036396114,-0.09188225,0.034697145,-0.026877292,-0.061797053,-0.00027925687,-0.0073610134,0.055909045,0.046701923,-0.008263517,-0.07854652,0.132513,-0.06655938,-0.013152568,0.019220775,0.10488296,0.056370392,-0.020510184,0.014110688,0.039889712,-0.01982761,-0.013831507,-0.07602021,0.023115626,-0.011851656,-0.08819396,-0.049532253,-0.020011311,-0.04639657,-0.017386021,0.03699409,0.004397293,-0.036854014,-0.038325213,0.04561397,-0.0759131,-0.0010506648,0.02279836,0.030448489,-0.017924888,-0.049748257,-0.053620283,0.049423248,0.051285367,-0.01013497,0.044933867,-0.08076742,0.070667356,-0.040164582,0.049637977,0.067656346,0.0985959,-0.05092453,0.1256689,-0.038411178,0.09713409,-0.13004203,0.04855816,0.0635586,0.16293636,-0.02712999,0.045375187,0.083656825,0.017394014,0.09484483,-0.050101474,0.020263761,0.004862424,-0.0069009126,0.03898585,-0.02638831,0.018675953,0.01824588,0.024616867,-0.06677341,-0.009129013,-0.023415029,-0.014143313,-0.07972218,-0.024323575,0.06157615,-0.066163346,-0.049622025,0.017054262,0.006498026,3.3803032e-34,0.07561613,0.045517705,0.06326969,0.043609988,-0.004206578,-0.045796607,0.022134872,-0.06635195,0.010181361,0.007985856,0.09470076,0.056776963,0.007481297,-0.089042604,0.055727877,0.04934094,-0.039788704,0.002167368,-0.048022658,0.040172376,-0.00909531,-0.05585494,-0.02909758,-0.041104775,0.028844278,-0.027572628,0.035402395,0.015952598,0.040822167,0.0011141226,0.0106273,0.045909453,-0.0514217,-0.04672446,-0.11856417,-0.007337654,0.015503904,-0.06215036,-0.05596099,0.049674768,-0.10449354,-0.0049211713,0.081595406,0.03770783,0.039398946,0.008700334,0.020382803,-0.016301898,0.053391475,-0.04697823,0.038330637,-0.084768295,-0.045477454,-0.023309225,0.016774613,0.015993528,-0.00604328,0.09603643,-0.013054748,-0.017312981,0.089343734,0.028217962,0.014539622,0.06910025,0.0036476403,-0.07416653,-0.08047702,-0.018164808,0.02476618,0.026337426,0.0545778,0.058629915,-0.04603099,0.013361806,-0.056017704,-0.0041529275,0.036742795,0.050916422,-0.037294906,0.045444865,0.054177288,0.0017596717,-0.018949155,-0.0015462934,-0.0070082853,-0.018052265,-0.009092596,0.14546435,-0.05889997,0.013122306,-0.05267789,0.017284129,-0.049374763,0.15204471,0.009432528,-4.1975532e-08,0.01940131,-0.027039928,-0.038288146,-0.031499427,-0.02236631,0.03267857,-0.022214407,-0.015470821,-0.036146436,-0.032760732,-0.007724415,0.07594135,0.035351623,0.039696924,0.021995496,-0.08325891,0.021623196,0.011557662,-0.016621932,0.0030214724,0.013258514,0.005895392,-0.04762236,-0.05086436,-0.034683026,-0.060490657,0.010655038,0.024850238,0.009351577,-0.0059370245,0.054576088,0.038641725,0.011829216,-0.090489134,0.009885114,0.048157264,-0.0026754877,0.014075364,0.026595052,0.05126834,0.058715995,-0.04316176,-0.08369607,0.0076372097,-0.011917291,0.029905928,-0.047955453,0.049214408,-0.07037062,-0.04567342,0.016259829,0.031781778,-0.03283025,-0.019448236,0.033621773,0.06966584,-0.02447525,-0.04881503,0.0018927311,-0.106913865,0.1052803,0.014815211,0.07789577,0.029940775 +2.4.1.101,"The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. Its action is required before the other N-acetylglucosaminyltransferases involved in the process (GlcNAcT-II through VI) can act. While the natural substrate (produced by EC 3.2.1.113, mannosyl-oligosaccharide 1,2-alpha-mannosidase) is described here, the minimal substrate recognized by the enzyme is alpha-D-Man-(1->3)-beta-D-Man-R.",384,1.0,-0.0074949274,-0.047038257,-0.110191315,-0.05254404,-0.004963071,0.017619407,-0.039657623,0.0288302,0.026174108,0.0780485,0.06925521,0.028193034,-0.07954782,-0.014231216,-0.0641968,-0.08412007,-0.019217782,-0.013635258,0.008743076,-0.090137236,0.08923008,0.026714051,0.009732704,-0.013274784,0.016559357,-0.057292216,-0.025810126,-0.0622519,0.048681304,-0.076048926,-0.04348064,-0.081899084,0.049135715,-0.022204721,0.054840896,0.05066151,0.018443117,-0.030523812,0.0334304,-0.03785884,-0.013945879,-0.07777179,-0.0040167468,-0.008108778,-0.046956453,-0.00039973852,-0.0603817,0.02250405,0.035693463,0.028441135,-0.0072151623,-0.053825278,-0.035741415,-0.01982817,0.06461036,0.031658288,-0.068730816,-0.0026783138,0.032028437,0.08783847,0.043936785,0.008933746,0.022631692,-0.028414786,0.0026459487,-0.039579462,0.038262416,-0.10168757,-0.012241748,0.03372517,0.0048676264,-0.033409495,-0.061409887,-0.046341866,0.012291945,0.014712849,-0.07987794,0.0029522472,0.026678562,0.01968535,0.058847055,0.05564223,0.08646918,0.059391346,-0.08393139,-0.025727324,-0.046153232,0.06342541,0.097335465,0.03512946,0.033133697,-0.02377287,0.028452491,0.03909423,-0.026955884,0.0066219172,0.020949617,0.037466772,0.03135731,-0.021943059,0.024899801,-0.0017224362,0.03700701,-0.08451912,-0.07528803,0.07966532,-0.035286035,0.007140369,0.031710897,0.029591817,-0.008013633,0.06709995,-0.027497225,-0.00814482,-0.13806331,0.059341073,0.04543189,-0.09150691,-0.054625504,-0.034190595,0.02431976,0.0065816017,0.056415375,0.07490304,-2.2012134e-06,0.045421407,0.0051081525,-9.695223e-34,0.047542833,0.009662691,0.03568625,0.0023356897,0.02357983,0.025395958,-0.024777718,-0.04230402,-0.04108348,-0.005555487,-0.07218572,-0.050575286,-0.06002452,0.14287344,-0.034731228,0.15044786,-0.045170125,-0.06930936,0.027275061,0.017395724,-0.002262884,0.035888147,-0.014025145,-0.01216557,0.09760147,0.04110218,-0.07160187,0.015397751,0.045701753,-0.024520457,0.073319286,-0.11753094,-0.07679842,0.028915068,0.036283053,0.0048281704,-0.014792603,-0.029336318,0.032339226,0.05999475,0.042261187,0.053309545,0.02349433,-0.032248713,0.04329188,0.029193593,0.04054884,0.05134262,-0.048160695,0.09948297,0.041014977,-0.0050302697,0.012591759,0.05156184,-0.05246107,0.037668686,-0.032801826,-0.031714503,0.028494513,0.1085313,0.031903926,0.01455643,0.06702096,-0.023264162,-0.017569125,0.033934213,-0.0753091,-0.008113695,-0.010045705,-0.0008648156,-0.037784696,-0.082508124,0.046720102,-0.007704025,0.02368494,-0.090844765,-0.006486993,0.037944138,-0.0007960848,-0.014681956,0.01863137,0.044360884,-0.041846786,-0.016560461,-0.07943429,0.03839239,-0.06128105,-0.12613562,-0.020233823,0.025006184,-0.006878983,-0.0109427,-0.09044822,0.07024913,-0.021445302,-2.3535592e-33,0.11484695,-0.11096364,0.0727647,-0.026760168,-0.06374279,-0.005688605,0.049039073,-0.020078957,0.039699875,0.0050529256,0.03235419,0.03635976,0.019982226,0.0070048682,0.024149079,-0.050863784,-0.044217464,0.11385384,-0.017100053,0.024631975,-0.061352573,0.09907734,0.012527933,-0.017463407,0.05632936,-0.018511865,-0.01409049,0.06807754,0.0006044172,0.041569874,-0.02267423,-0.008498436,-0.032921217,-0.05141449,0.0032044908,-0.021186583,-0.04909135,0.047329746,0.00020060042,-0.0042895284,-0.043583073,0.09352825,0.043891206,-0.038142707,0.002960835,0.12101165,-0.05971119,0.02314464,-0.10559222,-0.019833934,0.01766683,-0.005073538,-0.014381959,0.073499106,0.07160703,0.08278115,0.03063368,0.039911438,-0.013238645,0.014195856,-0.027588896,-0.035995807,0.013080376,-0.044935234,0.07583069,0.07116915,-0.07431531,0.06396383,0.047747623,0.045403942,-0.026300794,-0.0335656,-0.0036398072,0.026803136,-0.038359772,0.009118982,-0.120964125,-0.06102093,0.009023598,-0.061643172,-0.024495492,-0.010488226,0.0008765605,-0.035661604,0.032484703,-0.03204412,0.09748738,0.12711163,0.015340799,0.11027744,-0.037550416,-0.049335413,-0.08177518,0.070438616,0.038671717,-4.345552e-08,0.005163297,-0.025219232,-0.016507769,-0.1153151,-0.003128964,0.0064858967,0.010779833,0.03232783,0.021035211,0.0045342175,-0.03794861,0.024339175,0.0015847554,0.03361675,-0.034580905,0.057220638,-0.046026066,0.027378483,-0.042983647,-0.004862597,-0.14621378,0.0095085,-0.086302154,0.03750183,-0.011993383,-0.05043599,0.08047067,0.07721932,-0.051342696,-0.028733814,-0.0019390017,0.050060723,-0.014151599,-0.0766084,-0.031795233,-0.009992453,-0.037684202,-0.029918361,0.06836421,-0.049282487,-0.054652918,0.00035261374,0.031302746,-0.035537306,-0.019460522,0.0020493187,0.008023404,0.0023792502,-0.019158632,0.09610589,0.033967678,-0.00036818092,-0.05784193,-0.09224959,-0.07155533,-0.06913191,-0.06721217,-0.015075299,-0.010367382,-0.056088954,-0.010601783,-0.0547303,0.13122168,-0.037984263 +2.4.1.102,The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 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+2.4.1.103,"Acts on other hydroxy- and dihydroxy-derivatives of 9,10-anthraquinone.",384,0.99999994,-0.06577857,-0.07144657,-4.607039e-05,-0.05021453,0.11410268,0.03776371,0.034282945,0.07794937,0.023931984,-0.08158213,0.03435414,0.05954531,-0.054683007,0.079824895,-0.0055515543,0.055074506,-0.032719206,0.03321567,-0.03937599,0.031673517,-0.038665414,-0.0053260885,0.03077791,0.049457386,0.04813592,0.0356129,0.05045437,0.037658803,-0.06716774,0.0030798055,0.060535744,0.0032016016,-0.08652601,-0.015245706,-0.08565794,0.026660278,-0.06477601,0.025834858,0.08036225,0.05526164,0.06602864,-0.059079807,0.014595765,-0.030664118,-0.03655181,-0.010858277,0.03484639,0.081607975,0.031196665,0.093868084,-0.016190287,-0.021664603,-0.077573776,0.05868115,-0.009864298,-0.0894532,-0.087560676,0.0080965925,-0.037514478,0.0073002423,0.0032293797,0.025794594,-0.013816373,0.06988228,-0.11063618,-0.009991186,0.0074950303,-0.017166689,0.006653976,0.05831275,0.045156043,-0.022948323,-0.0035709732,-0.075898014,-0.06432035,0.05864918,0.0084625315,-0.040619235,0.047353804,-0.030705823,-0.043393034,0.03786419,0.09155631,0.12224079,-0.0070945825,0.010732368,0.032313768,0.07476046,0.0011784545,0.035776764,0.01138624,0.027992794,-0.022692578,0.009785796,-0.115297765,-0.015384087,0.044117026,0.028311891,-0.028763631,0.029190019,-0.048430927,0.03563627,-0.1146747,-0.06957182,-0.047595866,-0.02047472,0.014435233,0.029989075,-0.059104003,-0.09166818,-0.03767229,-0.023267167,-0.0010965534,-0.033230007,-0.06742071,0.030170105,0.0198666,-0.078340925,-0.07941316,-0.06772671,-0.026454374,-0.048584804,0.05182642,0.044958506,-0.082964726,0.04525965,-0.0154257305,-1.7184653e-33,-0.022626964,-0.0060967323,0.008666829,-0.008006188,0.036493,0.007288661,-0.13399054,0.02780255,-0.07737014,-0.025288308,-0.012983924,-0.020864012,0.0075757164,0.010575704,-0.026313754,-0.0052962913,0.02579324,0.007375262,0.03614547,-0.057972737,0.0077562635,0.06512003,-0.05090081,0.04720376,-0.058579177,0.024251658,-0.016946642,0.13884316,0.010936362,-0.022827229,0.002764712,-0.04537521,-0.022651663,-0.017055174,0.013561144,0.06279209,-0.06971989,-0.042682953,-0.0034228174,-0.021216694,0.006323789,0.019114893,-0.0036782252,-0.03178007,0.059262197,0.02562277,-0.021245975,0.113845624,0.050787263,-0.045370184,0.038798593,0.047967892,0.10946347,-0.020318698,-0.03305445,-0.05207493,-0.04937198,0.007869406,-0.00019971556,0.06916043,0.059030972,-0.03848245,-0.033054043,0.01822434,-0.030682966,0.025332956,0.01064383,-0.005573135,0.047459144,0.0281066,-0.0016034814,0.04645468,0.06920844,0.013107754,0.08439591,0.035772536,-0.025896024,-0.044241097,0.08319034,0.06663809,-0.03576139,-0.057299368,0.038780965,0.041682202,-0.06924443,0.026853178,-0.05252562,-0.0060728537,0.005319596,0.056513626,0.01612988,-0.105514646,-0.048069634,-0.01734144,0.015798647,-4.980034e-34,-0.051806413,-0.024658078,-0.051593844,-0.052585647,-0.059718907,0.10872136,0.037769787,-0.00574392,0.037244182,0.019950483,0.042107437,0.024349231,-0.037654426,-0.09809894,-0.024052445,-0.025213173,0.016571086,0.0829834,0.0028286532,0.0055519794,0.031669565,0.13860703,-0.029838832,0.018694192,-0.012500011,0.0066223918,0.026712129,0.047741733,0.07242705,0.0946361,-0.03535132,0.008909688,-0.06194816,-0.0081939725,0.015297084,0.073976725,0.019329501,-0.003767845,-0.025897054,-0.04628085,0.050046016,-0.067592874,-0.016425885,0.05728697,0.06447314,0.11281081,-0.09336639,0.08450796,-0.06778803,0.029090673,-0.0013857349,-0.029488944,0.012028871,0.00898341,0.049317524,0.046688415,-0.03704631,-0.048194736,0.01033945,-0.034046996,-0.031729337,0.00014036898,-0.018037487,-0.06326722,-0.099365085,0.04671652,-0.05535965,0.03739581,0.033865046,-0.06591742,0.04479226,-0.0039469455,-0.017630566,0.037355382,-0.050490554,-0.07601605,0.051007953,-0.07862409,-0.009594701,0.06637592,0.041797236,-0.02194702,0.024033895,-0.016363464,0.0039531006,0.03373778,-0.018647777,0.09048567,0.011159431,0.03772868,0.046408433,0.06594071,-0.028407572,0.0041478914,-0.005966141,-2.3272491e-08,0.019484734,-0.09989506,0.1387148,-0.10071759,-0.039668594,-0.014198939,0.059668172,0.058933992,0.0094137,0.011058331,0.0412142,0.06025118,0.011400888,0.017025582,-0.06196828,-0.04230663,0.03943305,-0.010871917,-0.05378225,-0.0511705,-0.1510945,0.0040169,0.04281936,-0.03801914,-0.0024567288,-0.03912977,-0.004572634,-0.057355195,-0.02167878,-0.002700202,0.06401591,-0.012179401,-0.052301813,-0.050645515,-0.06825028,0.062291145,-0.0361298,0.0131351845,0.080744274,-0.009162283,-0.023829527,-0.05519665,-0.045488413,0.06751609,0.038545415,-0.02012357,-0.07570603,-0.0259778,0.0042766137,-0.010353035,0.09683261,0.030935831,-0.0071375663,-0.086382285,-0.112274736,-0.053035703,0.0009665164,-0.055336628,-0.018402632,-0.054481503,0.0150009245,0.016202385,0.16046652,-0.03571966 +2.4.1.104,"Converts the aglycone daphetin into daphnin and, more slowly, esculetin into cichoriin, umbelliferone into skimmin, hydrangetin into hydrangin and scopoletin into scopolin.",384,1.0,-0.030932352,-0.10171975,-0.060729392,0.0031148724,0.031277366,0.0022928012,0.036695734,0.07286953,0.0050862497,-0.058596052,-0.03754124,-0.015397274,-0.10531241,-0.033014685,-0.08550491,-0.0040348424,0.028091533,0.082856305,-0.08498867,-0.03344633,0.08354499,-0.023844799,0.013287312,0.01574681,0.07702472,-0.00080460985,-0.096978895,-0.023930555,0.0049677463,-0.105582304,-0.0009596261,0.0018714996,-0.04665238,0.016933173,-0.019604392,0.07541445,-0.009662102,-0.0083167665,0.024679214,-0.08134848,0.14299445,-0.0052161315,0.037867706,-0.007636576,-0.017770955,-0.054019608,-0.1277301,0.05036902,0.037175935,0.09235685,-0.063925,-0.080290884,-0.08477644,0.041684963,0.009204473,0.075195976,-0.05643198,0.012887997,0.016034346,0.014656451,-0.01811613,0.014028567,0.009106831,0.013550966,-0.017162828,-0.036365908,0.04354348,0.005425413,0.07277734,0.008184269,0.00592248,0.0032927298,-0.0019972473,-0.0033143174,0.061804626,0.061668452,-0.04306946,0.03967744,0.00929302,-0.036092434,0.096186526,0.07640317,0.011682257,0.071296655,-0.03106936,0.016200472,-0.046542153,-0.023866422,0.044929955,0.040615287,-0.010161028,0.0005730482,-0.019976024,-0.05507959,-0.055503458,-0.040341638,0.013876375,-0.06291525,-0.03504546,0.054346215,0.0069775037,0.013952728,0.052856393,-0.14184411,-0.035321344,-0.02339223,0.048743237,-0.07363493,0.045832947,0.014629588,0.009789969,0.0010272934,0.06193672,-0.007634196,-0.03505157,0.0049232435,-0.02084285,-0.03975687,-0.023340965,-0.017507274,-0.027568199,0.010002707,0.029366702,0.04955991,-0.014272065,0.0066391407,-0.051099785,7.18335e-33,0.09031267,-0.04318883,0.03104097,0.02890015,0.038587227,0.037543222,-0.022095878,0.036676053,0.032185648,-0.043849215,-0.13823068,-0.027027545,0.027976433,0.11381425,0.027292319,-0.10660833,0.039785154,-0.0005411317,0.078260615,-0.040671512,0.09166501,0.062302098,-0.11925574,0.012010309,0.051043063,-0.020730069,-0.074665144,0.09771264,0.001094126,0.012154445,0.028080456,-0.03555161,-0.04966174,0.05048481,0.019409966,0.004316326,-0.017128984,-0.049128197,0.076949,0.08030987,0.009532961,-0.02114745,-0.034907203,0.0010493561,0.04206927,0.0054131425,-0.06267611,0.055559337,0.044337,0.03614462,0.015087889,-0.08386624,0.09837196,0.08730315,-0.06701607,0.071162604,-0.02658685,-0.021697326,0.03892974,0.01624126,-0.009810118,0.0061399415,-0.01832284,-0.021134205,0.022178426,0.041433845,-0.061561406,-0.028046774,-0.019223293,-0.016260372,-0.063877285,-0.012782256,-0.06346903,0.057528883,0.040731158,-0.03186406,-0.04271734,0.058047023,-0.006531697,-0.006516837,0.059599876,0.009585286,-0.04473219,-0.0013384825,-0.080382176,0.028236708,0.023865558,-0.040805183,0.034097288,0.012074124,-0.018877337,-0.085466586,-0.0062659434,-0.06873865,0.016584624,-5.9566387e-33,0.058130857,-0.03403236,0.058232445,0.10527693,-0.03776018,0.026730666,-0.009536193,-0.015336968,0.007237137,-0.047393896,0.018156288,-0.005302698,0.036545686,-0.06661048,-0.024064189,0.021506546,-0.007053243,0.07582852,0.057947382,-0.001538832,-0.037547335,-0.0032141577,-0.023461666,0.025620501,0.067387275,-0.026709914,0.0685192,0.026151322,-0.018807435,0.07077022,-0.035108894,-0.023321474,-0.09879879,-0.082569756,-0.15851872,0.012501132,0.031693015,-0.041007727,-0.092475034,-0.029661776,0.031170625,-0.0025310055,0.05637554,0.046248354,0.05069161,0.03962477,-0.08511117,-0.014191811,0.00031627185,0.039874714,0.06473998,-0.025733102,-0.0127024595,0.029956495,0.003858658,-0.008111669,0.12482661,-0.06744025,-0.06939709,-0.029641556,-0.024800533,-0.026043402,-0.0054037366,0.0033066494,0.056671828,0.049512986,0.006670722,0.07048775,0.021945156,-0.02259919,0.04493337,-0.04047318,0.121418275,0.057952236,0.05203342,-0.046226036,0.0076629785,0.009912794,0.053215537,-0.10594624,-0.034571227,-0.014954272,-0.00045001623,-0.04309,-0.05353706,0.06396555,0.076120876,0.041496985,-0.0030354306,0.09811147,-0.05353774,-0.03589578,0.005185792,0.065061234,0.08940324,-3.3202774e-08,0.10190776,0.008270898,0.035564695,0.02726506,-0.014232423,0.011281069,0.01745019,0.025150066,-0.043168087,-0.047310475,-0.09369562,0.10879491,0.014228456,-0.011955583,0.04966677,0.055644277,0.04573803,0.07953651,-0.04058081,-0.017097902,-0.070707425,0.02129009,-0.055616938,0.06902802,0.03439655,-0.056102164,-0.0058242413,0.07164776,0.038264405,0.051098507,-0.050648674,0.01194689,-0.030136984,-0.096835226,-0.010884089,-0.0010801419,-0.08255992,-0.073984556,0.031093922,-0.04048647,-0.03863927,0.03726046,0.020794047,-0.02704111,-0.0611263,-0.07411278,0.105586946,0.043434322,0.03134456,-0.0043365704,0.030214263,0.013397873,-0.014332038,-0.05553051,-0.08405314,-0.05668909,0.032034658,-0.05224264,-0.038408764,-0.0029940906,-0.070961185,0.013821373,0.100385524,0.018822536 +2.4.1.105,Vitexin is a flavonoid from Cannabis sativa (hemp) and some populations of Silene alba.,384,1.0,0.033873983,0.0044636047,-0.05165842,0.046826165,0.07427638,0.073837034,-0.009285174,0.11755299,0.023214735,-0.07178948,0.007864707,-0.035761137,-0.05564085,-0.018141212,-0.08817542,-0.034529246,0.07221094,0.019636948,-0.0035453783,0.037341587,-0.015321131,0.12101879,0.018376313,0.016897704,-0.023369752,-0.0008789144,-0.007583774,0.08381803,0.051953595,-0.00391676,-0.011910929,0.03481397,-0.00855465,0.04260683,-0.030408131,0.018325077,-0.062211484,-0.08717029,-0.019899458,-0.024846902,0.027770905,0.0028432608,-0.070909366,0.04957808,0.006938345,0.039106037,-0.045541752,-0.03791687,0.021702683,-0.021168906,-0.01618965,-0.096105725,0.0026363814,0.082365744,-0.025938982,-0.07735304,-0.050441902,0.011834102,0.034609452,0.072708875,0.047808267,0.07693097,0.033275794,-0.025834737,0.013111544,0.029183453,-0.005442817,0.08294719,-0.005180319,-0.09783589,0.024039133,-0.016692588,-0.055690423,0.09127061,-0.018526744,0.050446227,-0.05718772,-0.004898389,0.036269475,0.01184026,0.018672274,0.059545513,0.013094481,0.12598091,0.026278416,-0.01748512,-0.02987555,0.025108026,-0.032823686,-0.019303804,0.0034285125,0.084123425,0.006890836,-0.026772566,0.0012168983,0.016428906,0.011648977,-0.031011995,-0.018059216,-0.012080982,-0.067359656,0.0035201828,-0.045261268,-0.046385095,-0.03422896,0.03302422,0.027951064,-0.022568649,0.03660653,-0.09903035,-0.022767942,-0.012570585,-0.0058772303,-0.04941148,0.004356671,0.03190081,-0.013984867,0.023602566,-0.0187526,-0.017763551,-0.019325444,-0.0066968403,0.04871843,-0.042989604,-0.031838916,-0.063946046,-0.016613336,-3.2062267e-34,-0.06734913,0.0099375,0.003469707,0.078072175,0.05657341,-0.051884096,-0.025123911,-0.039281078,-0.08724433,-0.01717683,-0.09622247,-0.16107321,-0.04727889,0.04249118,0.050968416,-0.010968096,-0.08018661,-0.09948035,0.03353586,-0.088850655,0.044223838,-0.02540564,-0.003163452,0.02387385,-0.082965285,-0.060040142,-0.012878544,-0.054587495,0.018608246,-0.018783206,-0.044097997,0.07693865,-0.015851395,-0.034519475,-0.01970176,0.065109685,0.0016227152,-0.08525908,-0.07392152,0.07284812,0.06929654,0.072115116,0.02492473,-0.05998928,0.031943344,0.006622069,-0.14361298,0.04516167,0.07768562,0.016776899,0.016307762,-0.005135585,-0.0027083075,-0.020211779,-0.08192886,0.059210114,0.03610231,0.070825614,-0.012389948,0.05513697,-0.005051435,-0.008725133,-0.0080049,0.032195322,0.005850585,-0.008458029,-0.034661528,-0.046130616,0.0100628175,0.038143057,-0.025938096,0.041938756,0.012536844,-0.10133186,0.009457308,-0.08283232,-0.0748811,-0.03296704,0.06522737,0.005647156,0.007872526,-0.05723606,0.024141926,-0.0016529263,0.007896712,-0.06339948,0.027530285,0.021794012,0.020067878,0.01591191,0.095680356,-0.042279582,0.052686203,-0.057463825,-0.084386505,-3.336084e-34,0.0028670682,0.03506134,0.04586521,0.06856022,0.0498339,0.06176335,0.017633952,-0.035884514,-0.013357102,-0.003912351,0.10693766,-0.057006784,0.021156188,0.0017623289,-0.017086979,0.0958999,0.0070726983,-0.031881284,0.014768499,-0.016439458,-0.13597852,-0.043889742,0.040035423,0.03051784,0.02764921,0.023949742,0.053580258,0.0785208,-0.016306585,0.068572566,0.07085937,0.04538887,-0.06878342,-0.04015647,-0.012473647,0.068625234,0.055393938,-0.006999238,0.048199993,0.0030972944,-0.0020890753,0.031354267,-0.011827647,-0.011485298,-0.037423313,0.10385814,0.020093838,0.04044442,-0.0078033214,-0.062418222,0.10527912,0.044050638,-0.033797566,0.10647558,-0.059124336,-0.02476761,-0.02559565,0.0041783103,-0.07088192,-0.055386607,0.0044814115,0.06405703,-0.0205353,-0.03812387,0.04032434,-0.009122909,-0.0374482,0.023615414,0.07146938,-0.046719894,0.05280336,0.018596271,0.07991674,-0.01591531,-0.029685501,-0.077623,0.02317402,0.058003094,0.029350448,0.007975884,0.058691297,0.026958115,-0.03966647,-0.03424533,-0.0004170995,-0.030934535,-0.020915523,0.12238926,0.08171669,0.005422486,-0.08066466,0.004158188,-0.0749596,-0.065350786,0.08012821,-2.572016e-08,0.037242416,-0.018990181,-0.033515543,0.0018065111,0.024027567,-0.016745437,0.029770283,0.087444,0.033681825,0.044608213,-0.027059136,0.03473632,-0.04485158,-0.057047326,0.032465618,0.0035707925,0.0054706647,0.12982696,0.013339231,0.027651608,-0.034672488,0.032944113,-0.022628808,-0.031272575,-0.029325992,-0.0101494035,-0.053865165,-0.066853486,0.06984632,0.01344469,0.067069486,0.056350984,-0.00871874,-0.05158367,-0.1186938,0.024463981,-0.00044432186,-0.015155912,0.009493711,-0.05260483,0.003189364,-0.03472167,-0.07612933,-0.05094632,-0.057392213,-0.03557153,0.03735838,0.02603528,-0.004248304,-0.08368096,0.046298593,-0.013160213,0.03387609,0.040012058,-0.04797666,-0.03975009,0.038394798,0.021887222,-0.042208496,-0.18418379,-0.06483872,-0.035850957,0.19151591,0.041835837 +2.4.1.106,Isovitexin is a flavonoid from petals of Silene alba. ,384,1.0,0.0011648044,-0.07855012,-0.023950832,0.09069183,0.06314411,0.025593087,0.032282643,-0.017478386,0.0873577,-0.12199526,0.09763253,-0.036577288,-0.060035363,-0.026555737,-0.027045414,0.0054456154,-0.0085799275,0.00095213344,0.022328498,0.034204833,-0.0015342099,0.031117253,0.009810582,0.019730713,-0.034850534,0.0053739534,0.028524697,0.016239021,0.024962569,-0.0750003,0.0027773434,-0.030703427,0.078046754,0.016327443,-0.035338216,0.047302883,-0.06582998,-0.05251621,0.0039903647,0.044206146,0.036016546,-0.005898412,-0.027591366,-0.0024094344,-0.0071462346,-0.04893964,-0.06777713,-0.0083304215,0.038667873,0.019217422,-0.070282005,-0.08875358,-0.045991015,0.020847244,-0.034860827,-0.098109476,0.035754662,0.048478685,-0.011060276,0.055376466,0.06731902,0.016506867,0.02235591,-0.04491811,-0.069531366,-0.0025989541,0.029180434,0.048688106,0.072647214,-0.064299,0.030562676,-0.020833816,-0.083995104,0.06970725,-0.009843093,-0.020265052,-0.032817952,-0.019370005,-0.012420683,0.040265862,-0.008127245,0.07222731,-0.071523204,0.12796259,0.054138675,0.016397936,-0.13520277,0.03304811,-0.04148786,-0.0051713083,-0.018700624,0.069742694,-0.032253098,-0.02001247,0.01342575,0.049112245,0.02721604,-0.011634105,-0.057730757,-0.02708988,-0.04094899,0.018765714,-0.19812807,-0.06428038,0.010749963,0.0073915473,0.07425837,-0.10096984,0.012992726,-0.021070013,-0.06943149,-0.015865615,-0.046560846,-0.07493952,-0.013328369,0.02789099,0.036951024,0.0099455025,0.0020055962,0.0032328786,-0.04761628,-0.027743138,0.045506537,0.022966223,-0.009670871,-0.03945454,-0.04982642,-1.571399e-33,-0.0014630249,0.039981663,-0.035327066,0.054186337,0.04690772,-0.080479786,0.025062026,-0.033538375,-0.10583342,-0.10318839,-0.1172886,-0.10727581,-0.09038866,0.030281417,0.0927051,0.009291724,0.012902368,0.023698203,0.097520664,-0.092296176,0.03948719,-0.009779604,-0.022900695,-0.0047386424,-0.008905142,-0.0042053396,-0.061601978,0.0027111263,-0.03107661,0.002029265,0.010570183,-0.021096082,-0.032712404,0.0024744382,0.0017641673,0.0016975068,-0.036385138,-0.068678595,-0.08588367,0.067381576,-0.020462492,0.05951024,0.055003088,-0.041020602,0.00275662,0.052049514,-0.06263244,0.096004695,0.16742787,0.0017339089,0.07283022,-0.0045196684,0.08272684,0.009027573,-0.10413311,0.0942898,0.04148361,0.030748773,0.008107264,0.06059548,-0.010370903,0.0038824857,0.041196145,0.033471398,0.050198793,0.06858226,-0.07784476,0.052960474,0.053324897,-0.0013345465,-0.05595652,-0.033241335,-0.0026723344,0.027209193,-0.0028912444,-0.012526612,-0.063488185,-0.05969062,0.11723587,0.024193099,-0.068825215,-0.040642437,0.0823507,-0.033562113,-0.019851036,0.033019453,0.04575224,0.12441484,0.033866007,0.017440896,0.06820184,-0.01309229,-0.021571804,-0.012686456,-0.09112797,-2.7549643e-34,0.012078815,-0.059175484,0.06504966,-0.054708168,-0.007096496,0.053753067,-0.10001248,0.020721622,0.019126134,0.063803,0.06748509,-0.039006222,0.01909101,-0.014511013,-0.031308834,0.06835779,0.022334859,0.07157188,0.013382369,-0.039003488,-0.11525224,-0.030159708,0.03822853,-0.03174577,-0.052393064,0.033277377,0.14621943,0.019496378,-0.05158893,0.030537138,0.0800755,0.0010035658,-0.104922555,-0.04016872,0.019456433,0.045406904,-0.042738378,-0.057378978,0.021628484,0.0126222735,-0.013920667,-0.0058630016,-0.026288727,0.024612669,0.036538117,0.01886337,0.010611842,0.015412452,-0.042009246,-0.023324031,0.07161568,-0.0029677125,0.052725468,0.08166434,-0.023281896,-0.013815267,-0.049848627,0.0684323,0.04479757,-0.062306862,0.005728969,-0.015087234,-0.04117359,0.012778117,0.06413778,0.033142347,-0.03465138,0.0417007,0.0014947788,-0.053579368,0.075793184,-0.0008696697,-0.0096441135,0.065462045,-0.0010747688,-0.044185434,0.010061813,0.03532107,-0.01616732,0.03171279,-0.0031001195,-0.0011307143,-0.04422184,-0.04441688,-0.030122371,-0.07386058,-0.008588635,0.0751536,0.032050036,0.025512481,-0.06261827,0.021859668,-0.0202722,-0.025713608,0.1183611,-1.9863464e-08,0.017471818,0.025669832,0.016389772,-0.0017662549,-0.010477104,-0.07822123,-0.06525256,0.02328222,-0.034615763,0.042501353,0.00082793244,0.05465231,-0.0012176802,-0.047183968,0.0076153227,-0.0608209,0.06947273,0.08265688,0.03507309,0.013502952,-0.00740033,0.04508769,-0.029338324,-0.08557892,0.003200419,-0.010802751,0.025263257,0.02494407,0.038549114,0.006349911,0.039509214,-0.002142943,0.019271383,-0.01017163,-0.095782146,0.07318598,0.033778764,-0.085208036,-0.0014822915,-0.020386722,-0.03929721,-0.065817066,-0.0409723,-0.037126333,-0.027264522,0.015724082,0.018309323,0.07068739,0.011373555,-0.026655747,0.0397099,-0.030039005,0.0045078476,-0.018853817,-0.034174006,-0.03133471,0.026029713,0.03685211,-0.017946513,-0.097010046,-0.01009778,0.0062596938,0.16013122,0.024924183 +2.4.1.109,"The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain alpha-dihydropolyprenyl derivatives, larger than C35.",384,1.0,0.0073803235,-0.06965743,-0.014994031,-0.12356423,0.09032399,0.009502771,-0.020834154,0.054413192,-0.036684517,0.05698565,0.046266336,-0.0032270057,-0.09932908,0.0142827025,-0.018528497,0.00048380275,-0.08098813,0.05493367,-0.04088535,-0.02690837,0.05979159,-0.034518022,-0.027807297,0.029298322,0.008053191,-0.008998126,-0.0285473,-0.051412128,-0.056896526,-0.10496976,-0.03211739,0.025952432,-0.044491787,-0.024199279,0.026888244,0.055443678,-0.01563837,-0.0030441477,0.055859815,-0.031419277,0.053774323,-0.0943831,-0.064559884,0.019931808,-0.04566425,-0.032189824,-0.019922405,0.11205106,-0.004517126,0.103909016,-0.08659527,0.01179138,-0.011525459,0.022814704,-0.075794645,0.009539372,0.00024041228,-0.03699745,0.014615049,0.0012005839,-0.03625279,-0.0025800546,0.056683682,-0.04096174,0.06992802,-0.11640348,0.046353023,-0.058217697,0.07408547,-0.04821916,-0.009664024,-0.06200439,-0.031278156,0.05170676,0.05762522,0.004069997,-0.038859207,-0.0224371,0.10671442,0.020404011,0.062299225,0.050926726,0.06303426,0.108239,0.00133714,0.011871443,-0.014942048,0.005070322,0.06231454,-0.017500998,0.025054341,-0.021902798,-0.034068078,-0.023953937,-0.044240985,-0.010862364,-0.011861887,-0.00039038202,-0.016552407,0.043885887,0.028587157,0.005874285,0.011608432,-0.08653476,-0.08318071,-0.011303163,0.02576847,-0.054477736,-0.049728546,-0.023302756,-0.010189733,0.0011009561,0.013088243,-0.024225134,-0.032895233,0.025318205,0.0010622458,-0.073844515,-0.026186356,-0.056893952,-0.032924138,0.08437554,0.047079217,0.073547326,-0.08100353,0.07315009,-0.09750086,2.90621e-33,0.039301384,0.012919401,0.090019085,-0.01448964,0.04570004,0.0066247727,-0.07816188,0.014655938,-0.04291235,-0.026159765,-0.11847146,-0.10208933,0.06855659,0.013276977,-0.02491698,-0.017185977,-0.037356805,0.0512647,0.027320554,-0.05090472,-0.008852818,0.097244866,-0.014285559,0.027698847,0.08865049,0.020911783,-0.1128998,0.055206135,0.09520064,0.025117356,0.015509988,-0.04534208,-0.033551745,-0.033055406,0.047161594,0.057590537,-0.08016429,-0.010482356,-0.00020493047,0.08563679,0.02833219,0.03603689,-0.027303226,-0.081432186,-0.0015886284,-0.045236208,-0.042981345,0.07016268,-0.08084841,-0.019247664,0.039865598,-0.06302847,-0.035369452,-0.0031163958,0.0020531898,0.037503798,-0.012074611,-0.026492879,0.060727302,0.061652213,0.028909288,0.069658205,-0.018966425,0.00225631,0.015566412,0.009511131,-0.07102298,0.06206833,0.033156566,0.034739025,-0.04654607,0.0003987644,0.12142345,0.007861267,0.077019446,-0.003125303,-0.11439206,0.015767762,0.022255696,-0.029926518,0.058992017,-0.020923598,-0.037209228,-0.009818214,-0.045061257,0.0028932246,0.001993586,-0.094053105,-0.054248065,0.011219393,0.06301298,-0.0977044,-0.04268332,-0.017331284,-0.023881536,-4.4481514e-33,0.09578461,-0.10607895,0.01134425,0.002149628,-0.036804087,0.009201421,0.088274986,-0.05313035,0.02564888,0.012490743,0.04767375,-0.044499986,-0.017453866,0.014121778,0.066543855,0.028026834,0.008568404,0.06374706,-0.02564357,0.051409524,0.023559162,0.01022321,0.039436873,0.12567207,-0.011328509,-0.022559242,-0.040160134,0.063454665,0.100159384,0.049772356,-0.0733473,-0.010937507,-0.043203827,-0.05397512,0.032214813,0.009634901,-0.075248495,0.07090525,0.050807483,0.012214928,-0.09589326,0.0069499076,0.020739866,-0.024549058,0.05458357,0.065898694,-0.04999466,0.018295337,-0.02381853,-0.048560914,0.016034717,-0.040028542,0.009205021,0.024260765,0.009397411,0.104472704,0.012880744,0.041973617,-0.035065956,0.010802769,-0.055098116,-0.05741763,-0.010203032,-0.031199653,0.059678752,0.051696934,-0.074859455,0.022765912,0.060627926,-0.069583364,0.018377276,0.039139166,0.08583198,0.016610274,-5.067205e-06,-0.05558484,-0.058021426,0.0048059076,0.008995156,-0.031247914,-0.025779242,-0.041473046,0.011627349,-0.016561579,0.005087434,-0.038049284,0.046023022,0.12402799,0.029717369,0.07880042,-0.03049502,0.022354195,-0.04613279,0.0539129,0.091998294,-3.3251425e-08,0.088833936,-0.0520315,0.070994355,-0.022183646,-0.02347341,0.06391555,-0.0060620056,0.009073305,0.057885293,-0.021885118,0.02342641,0.11910137,0.012228082,0.030687233,0.034953207,0.016967213,-0.031094475,-0.0078414455,-0.036095403,-0.066909544,-0.11944009,0.017490666,-0.034044694,0.054177422,-0.015734768,-0.041070856,-0.00079537235,-0.008466105,-0.04794275,-0.017920751,0.041631687,0.031080894,-0.011578135,-0.068483286,-0.00034955415,0.032122422,-0.03531679,-0.04762765,0.055724982,0.03542646,0.012999423,-0.059703495,-0.06800903,-0.042460144,0.075280495,0.01422991,-0.019487064,0.025541594,-0.027050372,0.018094243,-0.021200297,0.10699896,-0.038184457,0.0026503461,-0.008787182,-0.016407743,-0.07604644,-0.08023186,0.043645065,-0.095538236,0.04014329,-0.00016936816,0.16073562,-0.052653365 +2.4.1.110,"This enzyme, found in higher vertebrates, modifies tRNAAsp at the wobble position of the anticodon loop. ",384,1.0,-0.048079632,-0.06673459,-0.060943224,-0.07441721,-0.050969675,-0.088885784,-0.01443681,0.06668723,0.0048631732,0.05132726,0.06722913,-0.033369943,-0.043716863,0.006481505,-0.11306385,0.07482621,-0.038893905,0.0053009056,0.09736775,-0.024806272,-0.007969174,0.10197045,0.03740732,0.042937234,-0.04259575,0.03591802,0.007609481,-0.017344223,0.017647626,-0.06218112,-0.08542133,-0.023612661,0.049470536,-0.07712358,0.0072263707,0.052402068,-0.11339867,-0.01916098,0.07620584,0.042069905,0.024743734,0.048175797,0.010095224,-0.04447414,-0.024825955,-0.008380368,-0.03192969,0.059616838,-0.015996743,0.10376209,-0.013256237,-0.030212719,-0.05140531,0.03399936,-0.041353934,0.11217403,-0.044648588,0.00866482,0.0076815677,0.018849418,0.093680225,0.052481025,6.7295405e-05,0.024992732,0.09951314,-0.047312025,0.03416586,0.008598103,0.02749766,0.015460769,0.009852556,-0.021691553,0.018101573,-0.004822714,-0.0037711177,-0.011440162,0.045664016,-0.019130686,0.017309336,0.06016351,-0.033334468,0.053770185,0.048035346,0.04395903,0.051076394,0.014265739,0.020402478,-0.004407533,-0.009966974,0.06967385,0.047802247,-0.014939131,-0.08188422,-0.031756923,-0.03080117,0.051039312,-0.004256056,0.040486727,-0.058635425,-0.06410623,-0.03377332,-0.005082997,0.030237034,-0.031658016,-0.015994184,-0.059815146,-0.0045082984,-0.044587944,0.04029426,-0.013353892,0.0074477005,0.0481885,0.077816054,0.043010347,-0.019581372,0.058188368,-0.008419202,0.0037168039,0.015540423,-0.016362753,0.019231338,-0.0411491,-0.010379869,-0.0026056592,0.010284693,0.0042890143,-0.13009153,-1.5238223e-33,0.005439278,-0.06955337,-0.021392219,-0.053524528,0.04605704,-0.027538884,-0.10624851,-0.0049552233,-0.09894013,-0.022288637,-0.08785791,-0.062316652,0.057503942,0.02213724,0.0043583433,-0.07909307,-0.049068075,0.02376279,0.020907331,-0.045236465,0.023088178,0.024813214,-0.0012994763,-0.0032637543,-0.0032204122,0.08927695,-0.083258346,0.04778821,0.038974546,0.021675017,0.025711684,-0.053049706,-0.08000637,0.0012230298,0.09736834,0.0012591212,0.034217115,-0.099305645,-0.07179385,0.04275865,0.024908185,-0.017370226,-0.0068556485,-0.0061064456,0.019578798,-0.086639754,-0.033861097,0.03908655,-0.0017870052,0.021391276,0.084566414,-0.05154919,0.02086758,-0.03698358,-0.07127742,0.015619613,-0.01100513,-0.048559558,0.008721866,0.10711504,-0.034944307,-0.0010995396,0.008529226,0.03149625,-0.03141552,-0.019269653,-0.05154813,-0.12112476,0.023239186,0.024910958,-0.01623849,-0.024827003,0.028011601,0.0029496637,-0.02653499,-0.029899435,-0.0046403054,0.03920845,-0.030782994,0.014869729,0.040913757,-0.088306375,0.017521305,-0.018954199,0.016501002,-0.0041047223,0.03507177,-0.06667494,0.0569319,0.08742868,0.032926105,-0.012948806,-0.089492634,-0.023918638,0.052252423,-8.432334e-35,0.05720713,-0.1416222,0.05712147,-0.010259182,-0.11134862,0.12062771,0.00039284254,-0.07180268,-0.020553071,-0.12975417,0.07365509,0.044983137,-0.05934664,0.015533817,0.07845641,-0.0028481602,0.007850316,-0.022176312,0.007124009,-0.08155234,0.0360206,0.010244668,0.019867184,0.024266113,0.061184425,-0.018364934,-0.033394374,0.02946294,0.007329971,0.026000742,-0.07349765,0.02318802,0.013624213,0.049006328,-0.049678106,0.11006619,-0.004643566,-0.0052205874,0.031904843,-0.035482284,0.058911685,0.011868164,0.045536496,0.06325621,-0.041338228,0.045889806,-0.04012245,0.01712687,-0.072180085,-0.004312807,0.11976469,0.07059467,0.06351253,-0.014963846,0.09122779,0.028234523,-0.06775739,-0.08005691,-0.005725918,-0.043894686,-0.021928946,-0.03839472,-0.033404343,-0.008125395,0.13357951,0.056932136,0.010107116,0.04458261,0.005253103,-0.046868313,0.024189813,0.0013428817,-0.032965913,-0.021887781,-0.031482637,-0.014023497,-0.022802774,-0.022493776,0.07667694,-0.053539697,-0.072806284,0.025188284,0.07048703,-0.039046004,-0.04951512,-0.05014791,-0.055947322,0.1575487,0.017791187,0.0909252,0.033904724,0.011365245,-0.027039228,-0.051991347,0.11976778,-2.3436723e-08,-0.036819767,-0.066365585,-0.022834238,-0.008590601,0.027730288,0.07907215,0.009881551,0.02674765,0.03631381,-0.018873585,-0.001200295,0.049697988,0.011082517,0.030854153,0.032676354,0.031496625,-0.034478974,0.035646923,-0.038444772,-0.043483514,-0.12036572,0.05242243,-0.07193143,0.0011198658,-0.011238776,-0.03324176,-0.033968106,0.078557625,-0.028056337,0.0028502773,-0.02039403,-0.008012224,-0.03005176,-0.048000492,-0.036820076,0.038981624,0.015617459,-0.030380359,-0.050279923,0.08773053,-0.004858644,0.07962902,-0.054036755,-0.021938786,-0.108727716,0.017577767,0.035352625,0.042601116,0.026512925,0.015081617,0.0056681824,0.060822353,0.08388522,-0.010553115,-0.098319046,0.032980334,0.011616371,-0.057862185,-0.09943905,0.08663451,-0.01857277,0.014187723,0.12637548,0.006620775 +2.4.1.111,Sinapyl alcohol can also act as acceptor.,384,0.99999994,-0.041818827,-0.043641593,-0.08612011,0.03698395,0.035997834,0.01322495,0.03452107,-0.009529368,0.045478284,-0.046269283,0.101502225,-0.013539519,-0.09871317,0.13960764,0.05553266,0.023066888,-0.025807481,-0.005359137,0.046197433,0.01907224,-0.0060973377,0.07052368,0.033223145,-0.06556421,-0.05585582,0.03911037,0.022716679,-0.014542429,0.032054383,-0.07333549,-0.0213244,0.04133506,0.003841954,-0.024266863,-0.042390402,-0.036024936,-0.10829185,0.02006252,0.054364707,0.006821572,0.0329269,-0.016614629,0.020476619,-0.027988063,-0.10934237,-0.017103236,-0.0149885705,0.0683426,0.022522287,-0.03799555,0.013476738,0.010635291,-0.026519261,-0.002052275,-0.030391302,0.028675787,-0.06886,-0.05783874,-0.040211752,0.035826385,-0.01717316,0.009556303,-0.046171524,0.03389831,-0.018283458,-0.049276397,0.046296887,-0.012287231,-0.014109872,-0.0148066385,0.008801691,-0.0896152,0.040346354,0.06688102,0.042124987,-0.05662325,-0.013545704,0.032858953,0.036727984,0.08224682,-0.09427166,0.005695423,0.014135543,0.07142183,0.08962306,0.004953115,-0.113969415,0.023879454,-0.05300496,0.07817374,0.0022960843,-0.04445876,-0.005891647,-0.081612855,0.086414434,-0.044965144,0.07313846,-0.011270491,-0.07045253,-0.0032177512,-0.06575271,0.039641835,-0.06770915,-0.08652481,-0.014739688,-0.034024864,0.03691165,-0.055458255,-0.012752433,-0.050974894,-0.025708418,-0.07154818,0.09436739,-0.009502685,-0.024007378,0.107595414,-0.0065267915,-0.03823266,0.029083427,-0.058435127,-0.07524043,-0.009071055,0.030950638,0.039864764,-0.030007752,-0.0034941365,-0.006300017,-1.6917735e-33,-0.07022837,0.0018524452,-0.062925555,-0.013532568,0.005960952,-0.045848392,-0.041662917,-0.014685706,-0.009703102,-0.06691709,-0.05631534,-0.031053953,-0.012056894,0.0980259,0.018242639,-0.0016042466,-0.0069099865,0.09029842,0.0053442763,-0.09646443,0.041809615,0.03207052,-0.018326608,0.010869236,-0.092743576,0.048059344,0.01618034,0.031545766,0.05058139,-0.023436818,0.041251082,0.02569203,0.017504152,0.06765265,0.000109959816,0.08884409,-0.02453748,-0.02242032,-0.062538624,-0.030358458,-0.009160367,0.07317575,-0.070591204,0.02239954,0.015814295,-0.026453614,-0.08784737,-0.040973302,-0.009598767,0.05286817,0.017286021,-0.011933955,0.056847382,-0.05144218,-0.06379897,0.0070720757,0.049073614,0.007874714,-0.052503645,-0.02917132,-0.069746755,0.027154896,-0.02106499,-0.041968364,-0.021795252,0.057348587,-0.024032244,-0.12654576,-0.025179468,0.006799132,-0.019820223,0.027558256,-0.012215082,0.05386219,0.027701302,-0.049427457,-0.022549942,0.041442033,0.06460035,-0.002508384,-0.06252027,-0.07934955,0.05086576,0.0270232,-0.008793245,-0.034236345,0.07467269,-0.104805686,0.043477025,0.015602121,0.034428094,0.020648817,-0.03160669,0.067451485,0.09044032,-1.4885315e-33,0.04487598,-0.0940762,0.018386576,-0.015917728,0.007988754,0.10500293,0.050060622,-0.046613988,0.09757336,-0.04584463,0.053907398,0.01639044,0.03809836,-0.028109066,0.05548249,-0.009441207,0.011263389,0.08441447,-0.056859974,-0.0035012208,-0.050860573,0.081176706,0.04626576,0.024438307,0.02699447,0.012601366,-0.015726592,-0.03509675,0.0015639616,0.02471375,0.012178114,0.014879156,-0.03952014,-0.06079628,0.006510292,0.037131637,-0.051909946,0.032314375,-0.12619962,-0.023404142,0.047856275,-0.00092914485,-0.033933032,0.08490827,0.0484134,-0.058020584,0.04289305,-0.061260965,-0.073520705,-0.046847846,0.04333023,0.017352946,0.03559554,0.0043069855,0.07962391,0.099405274,0.05727013,-0.13468957,-0.044432644,-0.038497355,-0.076453425,-0.0023962471,0.033549048,-0.008934274,0.056078076,-0.037788715,-0.03617124,0.071956694,0.048062462,-0.040887132,0.1337416,-0.041334078,0.009044372,0.08165746,0.017099315,-0.10500396,-0.039279453,-0.038780946,-0.04281001,-0.0530474,-0.09720112,0.0630758,-0.019920122,-0.011167876,-0.009972187,-0.09785673,0.011171859,-0.026970387,-0.015284776,0.07971611,0.03688634,0.04726678,-0.02950564,0.013729123,0.039235715,-1.8681948e-08,-0.025677636,0.0039841314,0.05427715,0.050459616,-0.07538743,0.012425001,0.07378834,-0.044062115,-0.06519411,-0.0262817,-0.011933957,0.12857139,0.09219566,-0.010930223,0.041418653,0.032951303,-0.08368343,0.010013028,-0.023372179,-0.024563821,-0.03740509,0.014199147,0.089104064,-0.00411785,-0.055907696,0.008932827,-0.009585319,0.06776479,0.0023502393,-0.0071774554,0.0013122675,0.015412781,-0.015767446,0.008068916,0.005054247,0.022178868,0.09898167,-0.08475907,-0.031311393,0.07114252,0.03229211,-0.0358377,-0.080708526,0.031418167,0.0025685844,0.020014334,-0.015672652,-0.016365247,-0.014106109,0.025044557,0.06769321,0.07795321,0.03404309,-0.010150983,-0.08322173,0.009229444,-0.036421485,-0.014210019,-0.009115867,-0.043666225,0.07498014,0.0163813,0.18024912,0.033333655 +2.4.1.112,"The enzyme builds up alpha-1,4-glucan chains covalently bound to protein, thus acting as an initiator of glycogen synthesis.",384,1.0,-0.027383711,-0.06565005,-0.09404333,0.010068481,-0.011598075,-0.030953923,-0.05855881,-0.017955003,0.0038419745,-0.020174928,-0.021490637,0.0609321,-0.034060955,0.008095144,-0.08752091,-0.025043145,-0.040816996,-0.045549095,-0.02863255,-0.017479666,0.04796096,-0.06598428,-0.052795183,0.0038435832,0.018739251,0.00077230943,0.02685409,-0.074323714,0.04388519,-0.07321241,-0.05001915,-0.07431779,0.052816335,0.022581946,-0.02350802,0.09021188,-0.008252414,-0.050810374,-0.020421218,-0.02206742,0.05094434,0.021490647,0.020472087,0.008320992,-0.07673362,-0.025029069,-0.013227931,-0.03404055,0.008755792,0.089340486,0.049155876,-0.049021665,-0.07610696,-0.007484557,0.019623874,0.037892804,-0.09031443,0.054473452,0.03774708,0.06513821,0.023402827,0.031035395,-0.02130759,0.0043536485,-0.019137014,-0.08089261,0.109035514,0.024966449,-0.06496588,0.028832287,0.019447505,0.012508043,-0.016385334,-0.011696008,0.04261251,0.050100163,-0.023256361,0.01755406,0.07819947,-0.011713285,0.08244899,0.014410059,0.06962453,0.09255261,-0.030580256,0.030645955,0.027876033,-0.037240453,0.060160235,0.022102464,0.045072913,-0.031461462,-0.007954145,-0.022706648,0.016083403,0.06518904,0.048588466,-0.02202739,0.05047782,-0.06499511,0.029903628,0.0089675905,0.023470929,0.013061849,-0.04972321,0.006786369,-0.02451214,0.06894018,0.039005116,0.057014253,0.0138899665,0.033106443,0.111680105,-0.008564206,-0.08737858,0.093749225,-0.014119686,-0.024279887,-0.03021804,-0.009191333,0.010101041,0.06138187,0.03006815,0.070257075,-0.067916185,0.01671619,-0.0127900895,-1.4295462e-33,0.102757014,0.044052973,0.042430297,0.039840892,-0.043500412,-0.04587386,-0.06987402,-0.02716618,-0.09999497,0.0068516727,0.022661006,-0.052583847,0.017200798,0.12518692,-0.021414919,0.030868182,0.03625788,-0.05521238,-0.01198791,0.060970716,-0.0077212425,0.030397756,0.013199453,0.0025379616,0.026868887,0.07479627,-0.049924634,0.040530063,0.027825346,-0.017374828,-0.036951445,-0.044867937,-0.08692244,0.061009552,0.05139086,0.020232752,-0.002346169,-0.058503218,0.05872432,0.043394648,0.024593553,-0.041299317,-0.02402324,-0.077175,0.07240901,0.03794867,-0.022762017,0.0089131845,-0.05734553,0.09848339,-0.001428953,-0.0022627353,0.01785419,0.03559842,-0.112419665,0.03366108,-0.02022602,-0.07548343,-0.007836361,0.015835302,-0.008604394,0.09088379,-0.014735357,0.0462642,-0.033529885,0.009486873,-0.018688705,-0.020198755,-0.024019483,0.09468065,-0.03357395,-0.07344337,0.0040843147,0.017947728,-0.022679979,-0.010746355,-0.02068449,0.0046082553,0.0216134,0.034655467,-0.023287553,0.039703496,-0.020147813,0.010005127,-0.10690977,-0.051108893,-0.00267005,-0.06557379,-0.021362428,0.09039663,0.01611558,-0.031432178,0.006323816,0.0615811,-0.072102636,-2.5813617e-33,0.15354852,-0.17762421,0.08200387,-0.02570027,-0.114898294,0.029379502,0.012546922,-0.11401163,0.038867448,0.014689391,0.019567221,0.05180119,-0.03690463,-0.018080322,0.015741788,-0.04452552,-0.052248225,0.060044635,-0.02469265,-0.015625097,0.044628598,0.024751442,0.021558618,0.023762934,0.047680054,-0.050829783,0.044574436,0.07495722,0.0074323905,0.035696566,-0.02015937,-0.04494515,0.0010964109,-0.03952388,-0.0737237,0.05618396,0.030248934,-0.005740366,0.0011930421,-0.066879004,0.01165236,0.1020797,-0.014091925,0.044809144,0.08896852,0.04309403,-0.027677244,0.06521267,-0.0016499128,-0.02175129,0.032808132,0.027031748,-0.00957544,0.036067206,-0.010147569,0.017118001,0.028144496,-0.007823365,-0.006605099,0.0031894718,-0.10892344,-0.066962704,0.010973292,-0.04785505,0.013357681,0.041372273,0.038384076,0.0071525183,0.044172652,0.046472732,0.02821091,-0.03455379,0.03533317,0.05115302,0.026831973,-0.004146647,-0.072748214,-0.100246646,0.005827251,-0.102163784,-0.06897572,0.036230583,0.00020318272,-0.043847136,0.06150532,-0.082762025,0.05895647,0.15383637,0.04017241,0.053600777,-0.027405221,-0.036523778,-0.01494019,0.022605622,-0.00986862,-3.009822e-08,0.029231926,0.023846412,-0.009784297,-0.06536742,-0.037092622,0.058743257,0.01380589,-0.02421098,0.005206333,-0.0059563904,-0.008267507,0.062175572,-0.036049496,-0.040050592,-0.025783414,0.049493574,-0.096695065,-0.02309325,-0.03917438,0.011467554,-0.12757722,-0.0123663945,-0.15654437,0.047169577,-0.024752222,-0.09586902,0.024718981,0.08642625,-0.047278997,0.03127839,-0.013452771,0.055693228,-0.04316591,-0.09886891,-0.055361323,-0.03398572,0.021660034,-0.019621693,0.06350693,-0.021913555,0.021624347,0.052827474,-0.0035999448,-0.04587517,-0.09138084,0.0065391776,-0.061280556,-0.05304637,0.0062133786,0.10550489,0.016429909,0.016113702,-0.034194358,-0.08163307,-0.08198592,-0.058926553,-0.018993227,-0.030219924,0.023316119,-0.05667697,-0.052272342,-0.04080693,0.1587971,-0.04688806 +2.4.1.113,"The enzyme builds up alpha-1,4-glucan chains covalently bound to protein, thus acting as an initiator of glycogen synthesis.",384,1.0,-0.027383711,-0.06565005,-0.09404333,0.010068481,-0.011598075,-0.030953923,-0.05855881,-0.017955003,0.0038419745,-0.020174928,-0.021490637,0.0609321,-0.034060955,0.008095144,-0.08752091,-0.025043145,-0.040816996,-0.045549095,-0.02863255,-0.017479666,0.04796096,-0.06598428,-0.052795183,0.0038435832,0.018739251,0.00077230943,0.02685409,-0.074323714,0.04388519,-0.07321241,-0.05001915,-0.07431779,0.052816335,0.022581946,-0.02350802,0.09021188,-0.008252414,-0.050810374,-0.020421218,-0.02206742,0.05094434,0.021490647,0.020472087,0.008320992,-0.07673362,-0.025029069,-0.013227931,-0.03404055,0.008755792,0.089340486,0.049155876,-0.049021665,-0.07610696,-0.007484557,0.019623874,0.037892804,-0.09031443,0.054473452,0.03774708,0.06513821,0.023402827,0.031035395,-0.02130759,0.0043536485,-0.019137014,-0.08089261,0.109035514,0.024966449,-0.06496588,0.028832287,0.019447505,0.012508043,-0.016385334,-0.011696008,0.04261251,0.050100163,-0.023256361,0.01755406,0.07819947,-0.011713285,0.08244899,0.014410059,0.06962453,0.09255261,-0.030580256,0.030645955,0.027876033,-0.037240453,0.060160235,0.022102464,0.045072913,-0.031461462,-0.007954145,-0.022706648,0.016083403,0.06518904,0.048588466,-0.02202739,0.05047782,-0.06499511,0.029903628,0.0089675905,0.023470929,0.013061849,-0.04972321,0.006786369,-0.02451214,0.06894018,0.039005116,0.057014253,0.0138899665,0.033106443,0.111680105,-0.008564206,-0.08737858,0.093749225,-0.014119686,-0.024279887,-0.03021804,-0.009191333,0.010101041,0.06138187,0.03006815,0.070257075,-0.067916185,0.01671619,-0.0127900895,-1.4295462e-33,0.102757014,0.044052973,0.042430297,0.039840892,-0.043500412,-0.04587386,-0.06987402,-0.02716618,-0.09999497,0.0068516727,0.022661006,-0.052583847,0.017200798,0.12518692,-0.021414919,0.030868182,0.03625788,-0.05521238,-0.01198791,0.060970716,-0.0077212425,0.030397756,0.013199453,0.0025379616,0.026868887,0.07479627,-0.049924634,0.040530063,0.027825346,-0.017374828,-0.036951445,-0.044867937,-0.08692244,0.061009552,0.05139086,0.020232752,-0.002346169,-0.058503218,0.05872432,0.043394648,0.024593553,-0.041299317,-0.02402324,-0.077175,0.07240901,0.03794867,-0.022762017,0.0089131845,-0.05734553,0.09848339,-0.001428953,-0.0022627353,0.01785419,0.03559842,-0.112419665,0.03366108,-0.02022602,-0.07548343,-0.007836361,0.015835302,-0.008604394,0.09088379,-0.014735357,0.0462642,-0.033529885,0.009486873,-0.018688705,-0.020198755,-0.024019483,0.09468065,-0.03357395,-0.07344337,0.0040843147,0.017947728,-0.022679979,-0.010746355,-0.02068449,0.0046082553,0.0216134,0.034655467,-0.023287553,0.039703496,-0.020147813,0.010005127,-0.10690977,-0.051108893,-0.00267005,-0.06557379,-0.021362428,0.09039663,0.01611558,-0.031432178,0.006323816,0.0615811,-0.072102636,-2.5813617e-33,0.15354852,-0.17762421,0.08200387,-0.02570027,-0.114898294,0.029379502,0.012546922,-0.11401163,0.038867448,0.014689391,0.019567221,0.05180119,-0.03690463,-0.018080322,0.015741788,-0.04452552,-0.052248225,0.060044635,-0.02469265,-0.015625097,0.044628598,0.024751442,0.021558618,0.023762934,0.047680054,-0.050829783,0.044574436,0.07495722,0.0074323905,0.035696566,-0.02015937,-0.04494515,0.0010964109,-0.03952388,-0.0737237,0.05618396,0.030248934,-0.005740366,0.0011930421,-0.066879004,0.01165236,0.1020797,-0.014091925,0.044809144,0.08896852,0.04309403,-0.027677244,0.06521267,-0.0016499128,-0.02175129,0.032808132,0.027031748,-0.00957544,0.036067206,-0.010147569,0.017118001,0.028144496,-0.007823365,-0.006605099,0.0031894718,-0.10892344,-0.066962704,0.010973292,-0.04785505,0.013357681,0.041372273,0.038384076,0.0071525183,0.044172652,0.046472732,0.02821091,-0.03455379,0.03533317,0.05115302,0.026831973,-0.004146647,-0.072748214,-0.100246646,0.005827251,-0.102163784,-0.06897572,0.036230583,0.00020318272,-0.043847136,0.06150532,-0.082762025,0.05895647,0.15383637,0.04017241,0.053600777,-0.027405221,-0.036523778,-0.01494019,0.022605622,-0.00986862,-3.009822e-08,0.029231926,0.023846412,-0.009784297,-0.06536742,-0.037092622,0.058743257,0.01380589,-0.02421098,0.005206333,-0.0059563904,-0.008267507,0.062175572,-0.036049496,-0.040050592,-0.025783414,0.049493574,-0.096695065,-0.02309325,-0.03917438,0.011467554,-0.12757722,-0.0123663945,-0.15654437,0.047169577,-0.024752222,-0.09586902,0.024718981,0.08642625,-0.047278997,0.03127839,-0.013452771,0.055693228,-0.04316591,-0.09886891,-0.055361323,-0.03398572,0.021660034,-0.019621693,0.06350693,-0.021913555,0.021624347,0.052827474,-0.0035999448,-0.04587517,-0.09138084,0.0065391776,-0.061280556,-0.05304637,0.0062133786,0.10550489,0.016429909,0.016113702,-0.034194358,-0.08163307,-0.08198592,-0.058926553,-0.018993227,-0.030219924,0.023316119,-0.05667697,-0.052272342,-0.04080693,0.1587971,-0.04688806 +2.4.1.114,Coumarinate (cis-2-hydroxycinnamate) does not act as acceptor.,384,0.99999994,0.008387797,-0.046462134,-0.071135424,-0.029385077,0.013793232,-0.04722938,-0.009413856,0.037978828,0.052205887,-0.067904115,0.0799453,-0.017580872,-0.017344719,0.0431822,-0.017047564,0.002089527,0.008322608,-0.045546062,0.041570283,0.00540123,-0.029230386,0.016382342,0.0049181147,0.0076018427,-0.044572867,0.0441763,-0.018782506,0.032049134,0.037496105,-0.0023613526,-0.042164456,0.053843975,-0.09428193,0.030658823,-0.009366122,-0.009860631,-0.03545912,-0.051308356,0.05778139,0.06605435,0.033599097,-0.009104768,0.0067566093,0.0114694005,-0.0004329491,-0.05715985,-0.0021395532,-0.01773454,-0.017494185,-0.012135323,-0.041439574,0.00842588,-0.06854357,0.07326614,-0.059591047,0.06779133,-0.098700866,0.02303445,-0.0038311295,0.033635404,-0.0025284565,-0.022736814,0.0071647903,0.00040937282,0.0020283458,-0.041435413,-0.019523002,-0.035526555,0.014283831,0.00178461,-0.00498108,-0.026146052,0.011115237,0.07433999,0.010264877,0.0437397,-0.07916719,-0.021889638,0.062158786,-0.003528387,-0.01282261,0.04010282,0.06418721,0.03201223,0.04339869,-0.031341646,-0.020327246,0.073873684,-0.016739199,0.044297,0.020177068,0.03589329,0.0005499492,-0.05793942,-0.022692317,-0.03213464,0.062334392,0.028305793,-0.07930662,-0.044476677,-0.08209715,0.0747897,-0.11013923,-0.055451103,-0.060961347,0.0031386183,0.029102795,-0.010476465,-0.0031074807,0.01842822,-0.08882729,-0.074304506,0.049337436,-0.023160817,-0.060631074,0.16085196,0.00053412333,-0.069211625,-0.026395896,-0.040205862,-0.030627215,-0.058880426,0.023208799,-0.017046396,-0.052871235,-0.00678714,0.03767469,7.5092515e-36,-0.028741399,0.051814046,0.0141784195,0.03021517,-0.07294732,0.018490952,-0.08402817,-0.066479765,-0.014021276,-0.07329866,-0.03376182,-0.03871181,-0.025143748,0.06535055,-0.020538215,0.009827049,-0.03103586,0.054219138,0.03384868,-0.0146795595,0.10189992,0.13226938,-0.057181947,-0.00779045,-0.0787093,0.04306334,-0.015731128,0.05603939,0.07338903,-0.011245696,0.022168811,-0.06157156,0.03760519,0.0330715,0.0031487725,0.058109194,-0.06601819,-0.03486084,-0.008960206,0.011877064,0.027257582,-0.009807811,-0.015990742,0.013603774,0.08885364,-0.10099584,-0.025424004,-0.04499548,-0.032405652,0.029489765,-0.024888834,0.07292698,-0.0430696,0.013999902,-0.042652503,-0.028408516,0.03990437,0.05564998,-0.020684918,-0.0033868446,-0.060342703,-0.014452654,-0.04706845,-0.029339248,0.009630588,0.065490305,-0.07627996,-0.041105293,-0.03258845,0.0595632,0.001426891,-0.06469711,0.038263842,0.104444474,0.11144412,-0.052422773,-0.01774638,0.034149155,-0.0031800629,0.005247709,-0.044564493,-0.034117714,0.035483483,0.12323032,-0.04306634,-0.019124713,0.036646552,0.02876374,0.034435965,0.016668227,0.06924347,-0.034794852,0.0071457876,0.027607892,0.051332798,-1.861752e-33,0.021319572,-0.042491447,0.03801731,-0.042646475,-0.01538736,0.11834061,0.035860155,-0.08704544,0.13257729,-0.021430427,0.17050135,0.037881326,-0.083226435,-0.006075583,-0.019033073,-0.036296286,0.035747338,0.097258985,-0.08171238,0.04748145,0.021129875,0.05565575,0.017921345,0.067063004,0.023365365,0.071940556,0.098329164,-0.03872838,0.032885738,0.051585544,0.011479774,-0.023469672,-0.06595883,-0.07075528,-0.0020612832,-0.027265197,-0.08297401,-0.040906813,-0.15966703,-0.008303892,0.019696498,-0.06677844,-0.03336271,0.079085305,0.02834453,-0.00421125,0.0034867928,0.014774613,0.038118556,0.009921209,-0.035164498,0.031196183,-0.010119242,-0.017412424,0.12516393,0.024613941,0.04199321,-0.07574644,0.009471486,-0.03045933,-0.0029946617,0.019233473,-0.008032229,-0.073513046,0.06851306,0.0039932462,-0.009147837,0.05815965,0.093254805,-0.011402145,0.061666295,0.010215657,0.053682894,0.009067032,0.03202091,0.0018884233,-0.022684937,-0.0532507,-0.013978727,-0.07820963,-0.088766225,0.0071063726,0.019019317,-0.076483026,0.027637893,-0.014864468,-0.06805887,-0.007977382,-0.017449133,0.0855035,0.024009543,-0.01708782,-0.005464865,-0.036768246,0.03518297,-2.5699622e-08,-0.017069278,-0.03825038,0.06008702,-0.063947655,-0.033228155,0.017776573,0.006020153,-0.12218219,0.030760054,0.0036164282,-0.013424392,0.02087849,0.063139506,-0.034536097,-0.0181594,-0.046054643,0.030675448,0.03688966,-0.05734758,-0.048514932,-0.1933793,-0.043419696,-0.033722386,-0.019701907,-0.007883498,0.018428192,0.040334836,0.05055479,-0.01516932,0.020606296,0.07761431,0.0047872015,0.043510504,0.022516664,-0.028074766,0.023189213,0.13694343,0.035601918,-0.08279666,-0.03568779,0.052811123,0.0009775949,-0.053927295,0.045096777,0.053579688,0.080412045,0.051814277,-0.0033459684,-0.037894014,-0.01332361,0.03951369,-0.011090875,0.007333717,-0.0691784,-0.07872758,-0.022546232,-0.056297895,-0.032638393,0.008331127,-0.10319571,-0.014719723,-0.063518815,0.16919625,0.048074067 +2.4.1.115,"The anthocyanidin compounds cyanidin, delphinidin, peonidin and to a lesser extent pelargonidin can act as substrates. The enzyme does not catalyse glucosylation of the 5-position of cyanidin and does not act on flavanols such as quercetin and kaempferol (cf. EC 2.4.1.91 flavonol 3-O-glucosyltransferase). In conjunction with EC 1.14.20.4, anthocyanidin synthase, it is involved in the conversion of leucoanthocyanidin into anthocyanidin 3-glucoside. It may act on the pseudobase precursor of the anthocyanidin rather than on the anthocyanidin itself [3].",384,0.99999994,-0.12672995,-0.081018716,-0.14095438,0.01507675,0.07026566,-0.011637987,0.02158375,0.015575818,0.053104453,-0.03851399,-0.015913028,-0.018685982,-0.103997245,0.0025858616,-0.08501397,-0.011653882,-0.065589085,0.061180122,-0.03819956,0.0026316943,-0.0023509583,-0.04589381,0.03152141,0.019344175,0.037228733,0.0040252614,-0.007487131,-0.04423495,-0.05026132,0.0071813855,-0.0574905,-0.053631812,0.08146268,-0.048992597,0.02552235,0.03995578,-0.08041077,-0.016931806,0.018804012,-0.041307293,0.02039735,0.022908388,-0.044418115,-0.035706423,0.009661018,0.0006458019,-0.04490441,-0.0061452934,-0.025689732,0.014179545,-0.038683712,0.012103824,-0.061958108,0.006719624,0.03803734,-0.007769653,-0.12707122,-0.008395055,0.0345925,0.10228179,-0.023088189,0.029235972,-0.028486341,-0.015261984,-0.047339767,-0.045988526,0.016560704,-0.052223247,0.02184424,-0.026485661,-0.047005486,-0.013474717,0.016930584,-0.028963855,-0.006331549,0.15954515,-0.019291352,0.027350128,-0.023226874,-0.04061791,0.08302277,0.017402846,-0.03413484,0.079330616,-0.018604582,-0.010301048,-0.040572725,0.029918853,0.017769052,0.1069937,0.11378224,0.06171896,-0.040624578,0.018009135,-0.013305775,0.020761553,0.051763125,0.03884826,-0.0029362252,-0.016584028,-0.025592975,0.019641638,0.097723335,-0.12298085,-0.08171971,0.023681998,0.006369476,-0.010706426,0.086019225,-0.0009105875,-0.03269619,-0.020818084,-0.016264362,-0.061497886,-0.0035205623,0.06410042,-0.043311805,0.0012258715,-0.0075576,0.08406609,-0.071296975,0.0019622578,0.012175286,0.066910036,-0.012241366,0.0023608017,-0.04199736,6.399838e-33,0.04478339,0.031748034,-0.026858775,-0.020743009,0.009118706,0.017566191,-0.015021333,0.04850327,0.021987306,-0.016661506,-0.051358335,-0.06701822,0.026582811,-0.020218069,-0.08311435,0.023945814,-0.024685387,-0.11025813,0.09113522,0.01527837,0.114459395,-0.010366385,-0.13564532,-0.025928805,-0.026973035,0.042445846,-0.0038366208,0.043713693,-0.016235571,0.020019853,-0.04510929,-0.10885871,-0.041297957,0.017350622,0.028349098,0.018256215,-0.05368291,-0.08480105,-0.0016573363,0.06618326,-0.029446296,-0.06162668,-0.018259494,0.0031726256,0.05018984,0.010157362,-0.05146393,0.0956908,-0.011300569,0.08040073,0.040619556,-0.06845615,0.08446931,0.041568544,-0.077126525,0.023520842,-0.044767145,-0.032624207,0.058829993,0.02084428,0.034167618,0.050832726,-0.001383698,-0.035360213,-0.035653096,0.061262053,-0.12258334,-0.06933373,0.0016586188,-0.0323529,0.030988678,-0.069278486,0.018271519,0.04828391,0.10089495,-0.0024580117,-0.10902417,0.084525764,0.065403424,0.01941859,-0.050808195,0.04276809,0.033169627,0.07228486,-0.035321683,0.01354485,0.002558096,0.011635313,0.02357045,0.047545914,0.050035153,-0.13997492,-0.023478711,0.045137443,0.027975213,-5.792784e-33,0.11334836,-0.037652496,0.029274236,-0.06472795,-0.044973925,0.0175423,0.03074081,-0.040898975,-0.026053105,-0.04060414,0.03738639,-0.03969633,0.0475735,-0.014952263,-0.005945116,-0.014213148,0.00682822,0.02766101,0.0032659278,0.047689848,-0.018649274,-0.031902224,-0.05801017,0.05250545,0.08523478,-0.005931936,0.07389125,0.014238,0.0047652996,0.102209836,-0.05937108,0.027232448,-0.046407267,-0.020864334,0.03261625,0.023766246,0.018225448,-0.004174516,-0.029050156,-0.027328257,-0.049447123,0.014079186,0.0021887738,0.07685276,0.08466731,0.087825,0.0091356225,0.039552283,-0.01311786,0.019871598,0.0077518956,0.066836834,-0.035813402,0.017979026,0.009261715,0.071839176,0.081011176,-0.033100557,-0.0135773495,-0.042896353,-0.05441795,-0.12728879,0.048700806,0.0078073377,0.073753595,0.112254195,0.06290299,0.10619049,0.047475267,-0.052664485,0.06561498,-0.065893486,0.087076165,0.02701313,-0.038152136,0.0041412683,0.08556698,-0.038674526,-0.004676811,-0.056482326,0.05714232,-0.04796587,0.0014595606,-0.02530692,-0.035957396,-0.04962047,0.06526888,0.0319925,-0.08723919,0.027728928,-0.03033439,0.06305218,-0.02890581,0.0720125,0.09561911,-4.2475207e-08,-0.013644347,-0.016313396,0.0037442641,0.01119627,0.05550018,0.019825066,-0.0018268814,0.0451591,-0.04084813,-0.02920762,-0.042440794,0.0656651,0.012499334,0.03516121,0.040639464,0.027783377,0.013910648,-0.002205488,0.017096853,0.019644765,-0.07786068,0.008797873,-0.119966984,-0.03641738,-0.00892401,-0.096017204,0.046207402,0.005948456,0.014075413,-0.028683236,-0.0114225065,0.013650343,-0.006079051,0.022638077,-0.005218711,0.020269347,-0.060893975,-0.09974298,-0.054266818,-0.07266114,-0.06665033,0.023174422,0.0090596955,-0.01852005,0.034083985,-0.06700155,-0.018836962,0.03255008,0.010867063,0.021617623,0.049804755,-0.008827193,0.012284718,-0.06309354,0.04066517,-0.029770652,0.038810074,-0.0150384065,-0.035904028,0.052588202,-0.09989219,0.0043053576,0.13642956,-0.016516738 +2.4.1.116,"Isolated from the plants Silene dioica (red campion) [1], Iris ensata (Japanese iris) [2] and Iris hollandica (Dutch iris) [3]. Also acts on the 3-O-rutinosides of pelargonidin, delphinidin and malvidin, but not the corresponding glucosides or 6-acylglucosides. The enzyme does not catalyse the glucosylation of the 5-hydroxy group of cyanidin 3-glucoside.",384,1.0,-0.091337,-0.11759958,-0.10051674,0.018741775,0.045407366,0.01802884,0.06884489,0.015675502,0.08469022,-0.010835883,0.07890252,-0.027716756,-0.122534335,-0.018810825,-0.07998561,0.017748618,-0.077834934,0.05184899,-0.04396766,-0.001212342,0.049103513,-0.05026215,0.011915199,0.05747018,0.018883076,0.014039912,0.027114801,0.007845559,0.0033098382,-0.07821211,-0.111487366,-0.025891583,0.042912528,0.01832952,0.040216926,0.059415784,-0.07969795,-0.070660084,-0.042217728,-0.0042595533,-0.027545348,-0.0015160855,-0.027459295,-0.004410518,0.0080366675,-0.06668227,-0.052676577,0.042936824,0.0010440428,-0.053348284,-0.017191151,-0.020576226,-0.034177653,-0.012284567,0.004803604,-0.028027575,-0.08686083,0.006442817,0.034779575,0.10238291,0.10156666,0.03097267,-0.025420161,-0.024540344,-0.15118396,-0.0038815467,0.022208104,-0.04788051,0.04737806,-0.059566565,-0.021138573,-0.06402898,-0.020415127,-0.02225667,-0.009811335,0.068048455,-0.023362081,-0.040833402,-0.0738672,-0.00028555602,0.069602095,0.049844094,0.06334367,0.064566,0.04420366,-0.011245661,-0.035427652,0.05886895,0.031338885,0.009705273,0.031028423,0.099603586,-0.010962774,-0.022973463,0.004219618,0.061100017,0.0473733,-0.104791,0.0098404605,0.022883696,-0.01738927,0.021750424,0.03818957,-0.08791489,-0.08751406,0.0705196,0.003833933,-0.011880212,0.039515644,-0.03513109,-0.06892434,0.035888333,-0.03305055,-0.017076675,-0.044786923,0.027992625,0.063373,-0.04398041,0.0326616,0.051406812,-0.039730698,-0.0021415867,0.062237248,0.030866146,-0.017405316,0.04534561,-0.05562465,3.877163e-33,0.06858165,0.022880428,-0.03907016,0.0014926897,0.01291577,0.03712871,0.034338906,0.016466111,-0.08928398,-0.04086006,-0.12163524,-0.07951506,0.009028772,0.0056152344,-0.01686008,0.06841391,0.00843749,-0.018226797,0.08812478,-0.030643726,0.08160364,0.042960204,-0.11415296,-0.037553344,-0.026869213,0.029710982,0.009840949,0.0134630585,0.0418937,-0.0231151,0.036995772,-0.05895592,-0.029955938,0.008343407,0.08532802,0.02824706,-0.034340996,-0.043180067,0.0133207515,0.09202259,0.005398604,0.018078646,0.029988416,-0.025490616,0.08443259,0.009265423,-0.09448058,0.051007695,0.025262827,0.046235465,0.012217899,0.01269127,-0.014057224,0.057010964,-0.054570414,0.033620797,-0.006022822,0.052142587,0.07293619,0.039237067,-0.011199458,0.038537085,-0.04630307,-0.069640405,0.04094383,0.021948613,-0.1517188,0.036438268,-0.08404484,-0.021272743,-0.021420652,-0.06105815,0.013848154,-0.0020929375,0.07294517,-0.018050592,-0.06298953,0.0933928,0.02630266,0.023664366,-0.026801175,0.04445492,0.055823002,0.029675836,-0.036684625,0.018255817,-0.017273048,0.012003256,0.0071495357,0.0074179233,0.06543267,-0.04113484,-0.055278093,0.0029536437,-0.019585356,-3.5184504e-33,0.07292307,-0.042565502,0.090211555,-0.065147206,0.021816649,0.037901502,-0.039243385,-0.03117253,0.0037664573,0.017153883,0.07587857,-0.018494746,0.048486404,-0.020745572,-0.020104669,0.004718411,0.052208148,0.09601764,-0.045014624,0.018132437,-0.10851783,-0.0029518886,0.008687958,-0.04713137,0.021194829,-0.001305759,0.12999967,-0.014789345,-0.07217198,0.048705895,0.012414016,-0.028152348,-0.08867321,-0.03351118,0.02487555,-0.020034637,-0.10770368,-0.11057341,-0.0048753405,-0.002754759,-0.01649304,-0.029655969,0.04377869,0.05312309,0.083791055,0.045157515,-0.0154931685,0.029546374,-0.09369499,0.0072380286,0.030753316,0.00058498513,0.024778223,-0.00012743921,0.06464613,-0.042255934,0.09800382,-0.00089321507,0.012091732,0.04148428,0.027014403,-0.030451735,-0.02089458,0.019266833,0.097752735,0.10640936,0.013151607,0.12552539,0.024075018,-0.059661206,0.055862837,-0.058507975,0.029835625,0.07087688,-0.02086583,-0.032060146,-0.010576413,-0.039320886,-0.0039364,-0.034243844,0.05472878,-0.0739942,-0.011400266,-0.007965378,-0.035002038,-0.062565684,0.05116273,0.06214944,0.026293345,0.009704723,-0.042809673,0.048285097,-0.013728755,0.050978247,0.17251654,-4.07367e-08,0.050512705,-0.0028933252,-0.01665131,-0.046303924,-0.036019128,-0.04569268,-0.017951146,0.05462893,-0.0278348,0.022231163,-0.018373726,0.046192966,-0.0022455084,-0.000796421,0.05953029,0.006458124,0.059531093,0.041402794,0.031050688,0.0386044,-0.08284672,0.052996423,-0.05011535,-0.02645013,-0.041789893,-0.0716653,0.0670247,-0.00751816,0.034720488,0.0075110234,0.054469023,0.027702384,0.043017633,0.029038804,-0.02271743,0.01030339,-0.046813708,-0.008147244,-0.05509335,-0.06376484,-0.055756453,-0.033085734,-0.016650079,-0.027541649,-0.06751193,-0.011650481,-0.036775906,0.024616955,0.03799109,0.01505808,0.022518156,-0.051922947,0.017951736,-0.022656558,-0.07956436,-0.0748675,0.07755335,-0.03280554,0.0015412435,-0.04990074,-0.11535371,-0.010712077,0.1159505,0.06775239 +2.4.1.117,"Solanesyl phosphate and ficaprenyl phosphate can act as acceptors, but more slowly.",384,1.0,-0.08935591,-0.124207206,-0.025215117,0.017115228,0.123199925,-0.06266627,-0.0025225629,-0.005650895,0.05879966,0.025030058,0.07775109,0.05292927,-0.07687022,0.12815933,-0.015848197,-0.011446911,-0.05153543,0.024791382,-0.006327564,0.045526665,0.030326404,0.0039170366,-0.03176415,-0.066159286,-0.0438577,0.01594668,-0.029273123,-0.011596289,0.021856965,-0.06011898,-0.076606415,0.018111346,-0.0015659268,-0.033632927,-0.020724237,0.09652332,-0.08223436,0.03321641,0.004409906,-0.043693326,0.008461801,-0.12132958,0.022854216,0.0037148676,-0.037376948,-0.08106775,0.01083266,0.012441435,0.016703267,-0.071751386,-0.08113799,0.03822656,-0.038614705,-0.009777767,-0.056891702,0.023526734,-0.1130886,0.022872621,-0.02292671,-0.033590265,-0.05896522,-0.018006232,-0.04279018,0.00938095,0.09041231,-0.015288667,0.07220282,-0.028197374,-0.0062286714,0.046342555,-0.018206308,0.014634762,0.038285863,-0.026135787,0.06733557,0.043448303,-0.062360473,-0.0029081283,0.032234028,0.08087436,-0.0060262303,-0.015795115,0.028538408,0.048698977,0.056490578,0.011805881,-0.07756132,0.025140285,-0.069272324,-0.005338683,0.024758384,0.0038444458,0.04299948,0.0030481655,0.025811363,0.037416928,0.036040023,0.004364028,-0.0120920865,0.0020168722,-0.06991331,0.042559,-0.07049866,-0.061106026,0.010349727,-0.03747771,0.017668836,0.0055664335,-0.030414458,0.012892572,-0.02260329,-0.030565439,0.06621587,0.053112045,-0.054905456,0.073010035,-0.018744111,-0.07871457,0.009001309,-0.028229006,-0.065235354,0.008019878,7.0749e-05,-0.040958162,-0.03039482,0.080607064,0.0018021562,2.631172e-33,0.020776657,0.031058002,0.014033317,-0.022825036,-0.073667906,-0.028722167,-0.039811984,0.006500274,-0.048549637,-0.013469469,-0.032875303,-0.034782078,0.040015947,0.010948195,-0.023924854,-0.079300635,0.0021608057,0.1159014,0.07173206,-0.034049347,0.07264403,0.052181665,-0.014498289,0.0036254397,0.0010385392,0.006331945,-0.1054113,0.022854602,0.06894467,-0.015140061,0.091309525,-0.0007836598,-0.044115447,0.050803542,0.012243726,-0.0062681194,-0.020071315,-0.036341563,-0.006701024,-0.094067566,-0.018293248,0.05937756,-0.07923912,0.06898575,0.02392341,-0.04153334,-0.088186406,0.00690849,-0.06258152,0.08465034,0.021802437,-0.0026229278,-0.048181284,-0.03097169,0.010316297,-0.034313004,0.021676302,-0.017845592,-0.045803655,0.050718877,-0.008552345,-0.02450767,-0.022355553,-0.010071619,0.02923245,0.012288273,-0.05006065,0.0050049727,-0.025446506,0.071959175,0.033605523,0.0070460634,-0.030076375,0.06719954,0.08741803,-0.07785047,0.06490192,0.021365544,-0.034187734,-0.022495577,0.0030608813,-0.08042584,-0.056928277,0.07221135,-0.058337476,-0.032360654,0.005212922,-0.09882228,0.08561534,-0.036326736,0.0448549,-0.06738369,-0.06512989,0.010006643,0.032009605,-3.5936626e-33,0.11360255,-0.06228046,0.034757514,0.026856853,0.0036894218,0.046395116,0.018641718,-0.076261885,0.14399974,-2.7114605e-05,0.05457147,0.018342495,0.036455918,-0.050376106,-0.09012754,0.086810976,0.032926336,0.015748931,0.017625028,0.020821545,-0.055430345,0.08970625,0.045100637,0.069643706,0.03793754,0.04607982,-0.019144632,-0.005493146,-0.09022811,0.054468244,-0.0057527437,0.022845568,-0.03305783,-0.07730965,-0.03772357,-0.0005662977,-0.11282489,-0.039211124,-0.023593375,0.0070665237,0.06400108,0.0088391835,0.027699145,0.0392354,-0.026952721,-0.024785232,0.063683935,-0.05211337,-0.042233165,-0.057170857,0.010851005,0.07046458,-0.0035980928,0.025157427,0.07926869,0.12041178,0.05215057,-0.047859516,-0.041222848,0.0038229504,0.020353775,-0.05095554,0.010269371,-0.034914,0.088873595,-0.0069202427,-0.0034944701,0.051390197,0.056619015,-0.009184386,0.12909377,-0.033507787,0.07179016,0.12537985,0.041977692,-0.05756896,-0.023857713,-0.035558738,-0.048680756,-0.04829053,-0.07823187,0.08178004,-0.017324248,-0.0695946,-0.009311576,-0.05843992,0.018235732,-0.0499105,-0.04016591,0.054668467,0.030766439,-0.011032652,0.084627606,0.089882925,0.07034035,-2.6430664e-08,0.040528324,0.0029108108,0.033386163,-0.03983659,-0.07152024,0.04882019,0.077672586,0.05510243,-0.052216403,0.0029368738,-0.0020343498,0.11311248,0.0878593,-0.03244458,0.11925964,-0.00993561,-0.016910948,-0.0062208213,-0.08747005,-0.09106051,-0.079421185,-0.0030948743,-0.031277463,-0.00017058391,-0.017891603,0.04351537,0.04430255,-0.0067919497,-0.018745698,-0.021020474,-0.007888276,-0.01692016,0.035202365,-0.031814277,-0.012102453,0.09341601,0.011706716,-0.044274826,-0.0701745,0.055877145,-0.036217663,-0.037635136,-0.11227588,0.013864494,-0.033204507,0.055436037,-0.034314618,0.051502656,-0.0017941818,0.018658973,0.06286486,0.010844343,-0.03333623,-0.035864413,-0.04188533,0.035617325,-0.008667866,0.03924597,0.038335864,-0.06790812,-0.0016479103,0.034760103,0.12232216,-0.026733756 +2.4.1.118,"Acts on a range of N6-substituted adenines, including zeatin and N6-benzylaminopurine, but not N6-benzyladenine. With some acceptors, 9-beta-D-glucosides are also formed.",384,0.99999994,-0.03251513,-0.06685157,-0.009888945,-0.018028915,-0.03537398,0.024124805,0.0068184882,-0.039101876,0.09406201,0.006749005,0.022442862,0.08706535,-0.062231522,0.037397623,-0.031256504,0.033330087,-0.037339807,-0.022948235,-0.025174068,-0.026636994,-0.07068695,0.08900786,0.06505579,-0.03116036,0.022918405,-0.040809494,0.05020247,0.05245595,0.08323065,-0.019674027,-0.0070221703,-0.0026279197,-0.055186458,0.040534787,0.05785325,0.027703263,-0.044925872,-0.0114456,-0.0033748453,0.039967485,0.019906247,-0.05554075,-0.022601271,0.03828969,-0.016065078,-0.02137831,-0.0053202803,0.037774637,0.0037736946,0.015554323,0.025048917,-0.090298325,-0.045407727,0.04361781,-0.0109437015,0.0039391145,-0.18688653,-0.062510535,0.09583147,0.050195925,0.05068805,-0.010355923,0.026914516,-0.00651675,-0.033777308,-0.008301798,0.024561742,-0.05302099,-0.04016426,0.036960136,-0.038775038,-0.008686237,0.03346429,-0.040988307,-0.04396497,-0.032630727,-0.04004959,-0.037642457,-0.007850002,-0.032779105,0.049339987,0.010406245,0.08890612,0.06865211,0.052467905,-0.03418238,-0.0014283031,0.10662017,0.035308912,-0.010104084,-0.02419487,-0.060225353,0.023932995,-0.03100317,-0.04119745,-0.068864316,0.032153755,-0.01863138,0.032297544,0.033133913,0.03042358,0.03409872,-0.07214777,-0.020364478,-0.0076836837,0.087374896,-0.025969313,0.08636208,-0.08111864,0.03636403,-0.10048686,0.023716807,-0.0012139037,-0.03906018,-0.05638936,-0.00057525345,0.010186803,-0.06238378,-0.058058575,0.010803291,0.00520951,-0.0018752185,0.039092336,0.070364155,-0.0794983,0.088563584,-0.07992862,1.50916035e-33,0.07029449,0.02338777,0.06977906,0.023991285,0.0109196855,0.018452965,-0.07215534,-0.0072257086,-0.022168515,-0.039392356,-0.09063501,-0.0022759507,0.091522485,0.023435682,0.051182862,0.04739094,-0.034352377,0.02821965,0.065583386,-0.099346295,-0.02626684,0.041538425,-0.05650565,-0.017570183,-0.043221515,0.043892026,-0.07001094,0.09022826,0.05507048,-0.047972087,-0.054590598,-0.051263288,-0.034030665,0.049798455,0.0008755568,0.09145868,-0.10127131,-0.026005922,0.05319849,-0.04431528,-0.019510528,0.035211105,-0.04643814,-0.038657136,0.021922141,0.006669623,0.015357967,0.016224211,-0.032914303,0.06853679,0.05621724,-0.018649451,-0.022892952,-0.05521304,-0.037938345,0.025993284,-0.0038959084,0.031316694,-0.012066865,0.05145942,0.012814185,-0.028443918,-0.011390603,-0.034899686,-0.059324782,0.06911126,-0.14338638,-0.044474587,-0.057455156,0.033851966,-0.007526621,0.0074060005,0.10423475,0.10346317,0.028729144,-0.03270304,-0.021299256,-0.008880187,-0.008133385,0.04048653,0.051198438,-0.021286549,-0.046809573,-0.006436077,-0.037185125,-0.028905788,-0.047123518,-0.09835909,0.04681168,0.045797512,0.006420417,-0.08014304,-0.09501044,0.011780253,0.035292115,-2.9711826e-33,0.070091,0.0066445777,0.024417806,-0.0040514846,0.029437374,-0.008198858,0.020629812,-0.118631236,0.0056218468,-0.043570824,0.030320989,0.04063852,0.005335514,-0.022568507,-0.025522206,-0.06412703,-0.005738267,0.030989548,0.04840392,-0.061053563,-0.06715298,0.012563236,-0.03644904,0.013781607,-0.029486807,0.031497993,0.04533664,-0.020310583,0.107881136,0.06660281,-0.08752286,-0.027026389,-0.065702185,-0.0014655145,0.086735256,0.0431136,-0.016588282,0.04708072,-0.050671462,0.0047152876,-0.0015053756,0.0033407365,0.035639722,0.14158024,0.022858955,0.10806739,0.025076104,0.016831527,-0.086934924,-0.094952345,-0.0026152956,-0.038209725,-0.031379174,0.056900304,0.104395665,0.14328979,0.072201736,-0.07066906,0.011184078,-0.023492616,0.018367112,0.0019576955,-0.00972728,-0.13544701,0.029478764,-0.034716528,-0.047159348,0.11737052,0.033798456,0.023084253,0.042439733,-0.028136866,0.01748587,-0.04374476,-0.02660283,0.008184997,0.0031943,-0.10051756,-0.013947002,-0.02820651,-0.033558656,0.054278042,0.0092337215,0.038912453,-0.020469857,0.0732691,0.08615727,0.068230204,-0.039524008,0.03739098,0.03422329,0.05161146,0.056755148,0.11153869,-0.0011183744,-3.3879516e-08,0.04836575,-0.05012768,0.009476922,-0.13684747,-0.019476322,-0.012515533,0.017153315,0.041677926,0.008064212,-0.0012307018,0.0070364582,0.0951854,0.011296477,0.018223125,-0.06368961,0.032246705,-0.07382522,-0.033967376,-0.03345843,-0.0075100674,-0.15692304,0.034414787,-0.016678965,0.020620195,-0.032171223,-0.034966182,0.030487305,0.04882823,-0.022420457,-0.0016718867,0.051404834,0.0332842,-0.0072195297,-0.09691383,0.0025596402,0.004268794,0.020692898,0.020699887,-0.020544115,-0.021811664,0.08716437,-0.05654418,-0.03026578,0.051082205,-0.009047068,0.03834038,-0.044925693,5.4573302e-05,-0.035854023,0.06396863,0.04377491,0.0016662623,-0.03829667,-0.026179582,-0.0576535,-0.025768917,-0.038475223,-0.045293424,0.052188285,-0.06376008,-0.024743585,-0.0065517975,0.1287647,0.019507613 +2.4.1.119,Transfers the glucosyl-mannosyl-glucosamine polysaccharide side-chains of glycoproteins to an asparagine residue in the sequence Asn-Xaa-Ser or Asn-Xaa-Thr in the nascent polypeptide chains of the protein moiety.,384,0.99999994,-0.011630749,-0.10246208,-0.07880404,-0.006077649,0.0059546977,0.04087937,0.053632665,0.059053652,0.038489852,0.011696679,0.061026204,0.09038039,-0.021194493,0.009383011,-0.07767216,-0.041727416,0.02499994,-0.037983123,-0.038145095,0.015689047,0.10477667,-0.0080294395,-0.030318374,0.005666029,0.034878574,-0.028328719,-0.025405342,-0.11327241,0.019991621,-0.07348759,-0.027365502,-0.04553342,0.0056137084,0.022432026,0.06262954,0.08119779,0.009701993,-0.06685925,0.07213095,-0.058237355,0.06271199,0.030956676,0.011166546,-0.06534476,-0.0736632,-0.028675115,-0.022705873,0.04160096,0.08822196,0.11140772,0.04875534,-0.035969157,-0.016486658,0.016888756,0.008650814,0.063474976,-0.10039981,-0.03392133,-0.016310783,0.058146037,-0.04857592,0.048739426,0.024684383,-0.004139414,0.0027651004,-0.08878862,0.089379705,-0.00086602964,-0.04877486,0.07827486,-0.023815036,0.06312336,0.015665893,-0.012951297,0.07376987,0.012951736,-0.07264871,-0.009457135,-0.006100936,-0.051837925,0.05378976,0.044162605,0.10622356,0.07015002,-0.08102822,-0.034861412,0.025493303,0.034476925,0.026977971,0.0059594144,-0.011541017,-0.038581114,0.05676105,-0.060164753,0.039254483,-0.08162328,0.08178693,0.0052495925,0.028934918,-0.026793594,-0.0045044404,-0.005519331,0.052722592,-0.09114287,-0.0048788013,0.02054533,-0.074249916,-0.015027838,0.100753106,0.028473202,-0.025352541,0.06393579,0.05622853,-0.038906515,-0.07830819,-0.005615428,0.022184297,-0.038802277,-0.068360254,-0.07775885,0.015915148,0.013028335,0.0086218305,0.10410074,-0.0017074011,-0.0131927775,-0.03211058,2.0274638e-33,0.018285865,0.03972045,0.12410549,-0.050034292,-0.009267568,-0.02467004,0.028173612,0.0035066747,0.002415445,0.013528245,-0.06722465,-0.08162814,0.027711894,0.065698646,0.00035293144,-0.011880494,-0.004378485,-0.046860106,0.0045655333,-0.05626633,-0.026190864,0.06557401,0.027758067,-0.00028335216,0.015185306,0.004029548,-0.01857121,0.046844766,-0.0022100508,-0.012706059,0.046433426,-0.03560178,-0.10170164,0.040478762,0.10787126,0.024801098,0.002467987,-0.05515195,0.042307544,0.056067303,0.026918529,-0.0041986117,-0.025145292,-0.092841744,-0.02781954,0.0057871123,-0.010985352,-0.01378611,-0.033810794,0.061412923,-0.0067616897,-0.024453014,-0.0068353475,0.0150239635,-0.070620134,0.003656181,-0.058595534,-0.049277775,-0.03144033,0.11566719,0.035142172,-0.082537025,-0.056893494,-0.067422904,-0.023742037,0.005364182,-0.015555726,0.01133837,0.020724613,0.0066187996,-0.056649316,-0.08608463,0.04007915,0.05118536,0.008538862,0.0063595506,-0.12805372,0.0744863,0.015472696,0.024963427,-0.008704758,0.07242961,-0.04079928,0.005267569,-0.095670134,-0.0062686545,0.10620418,-0.08755599,-0.00799547,0.018748833,-0.01839072,-0.09300159,-0.016016897,0.013663033,-0.022203961,-5.4224963e-33,0.08353669,-0.11262024,0.08344813,0.034042522,-0.059402384,-0.04383018,0.11562306,0.014191976,-0.02019193,0.0026833336,0.075794496,0.049620427,-0.02975329,-0.0005754399,0.039336074,0.050746463,-0.041870102,0.13911507,-0.033274133,0.0005720514,0.012476678,-0.042248454,0.04038451,0.005635977,0.040949885,-0.01083352,0.011471504,0.023993982,0.02347984,0.05873712,-0.023566257,0.013371932,-0.056052424,-0.08061169,-0.050975345,-0.044548962,-0.07113152,-0.029944854,-0.027865164,-0.08817503,0.02408576,0.0743848,0.0385368,-0.016871769,0.08771151,0.011982651,-0.08783305,-0.0018079624,-0.029951101,-0.022884559,-0.013576184,0.005963055,0.041269593,0.010053064,-0.0035133604,0.04618659,0.035353314,0.0370418,0.014757627,0.020723833,-0.06288673,0.02101026,0.040458944,-0.031949963,0.03206476,-0.014210904,0.021106778,-0.07638467,0.0486646,-0.028929353,-0.00044934574,-0.03407191,0.011123437,0.053880222,0.002736183,-0.08163469,-0.12474362,-0.009459834,-0.0157066,-0.045627028,-0.0013218899,-0.048292696,-0.03262656,-0.021848353,0.067884386,0.033816237,0.079377264,0.10439851,-0.014492157,0.028430577,-0.011446834,-0.017123336,0.021499997,0.08776938,0.09307079,-3.6546606e-08,0.050700936,-0.011704633,0.020550434,-0.10209136,-0.019433815,0.08232376,-0.03731369,-0.017316187,-0.059896853,-0.01835012,0.022073263,0.035857398,-0.024383228,-0.013137152,-0.10883262,0.055024628,-0.08921103,-0.0034761135,0.015251858,-0.005130518,-0.16280442,0.014785169,-0.08009968,0.05756641,0.029222714,-0.019250715,0.012948001,0.0803148,-0.0097555835,0.03884268,0.013012309,0.031494334,-0.043351762,-0.09869133,0.019538218,0.015193228,-0.015938569,-0.012851958,0.08539542,-0.0049449294,-0.041507035,0.013802252,0.030896427,-0.014304298,0.07286834,0.027877048,-0.010924726,0.01439064,-0.06228834,0.07298123,0.006840503,-0.020438958,-0.07741152,-0.084924705,-0.059207484,-0.049193393,-0.0717986,-0.08341276,0.020666135,-0.004742197,-0.019750956,-0.03692302,0.072033636,-0.026168622 +2.4.1.120,"Some other hydroxycinnamates, including 4-coumarate, ferulate and caffeate, can act as acceptors, but more slowly. Only glucose esters, not glucosides, are formed (cf. EC 2.4.1.126 hydroxycinnamate 4-beta-glucosyltransferase).",384,1.0,0.008687794,-0.08739396,-0.090393886,0.0026657183,0.029158024,-0.0015985867,-0.04206229,-0.0009770446,0.0790113,-0.08204441,0.05195623,-0.019699877,0.010873627,0.05499434,0.023581324,-0.017515577,-0.029840676,-0.0133568,0.0068527786,-0.006274517,-0.004017391,-0.0115068415,0.008186715,0.0013009821,0.016840875,-0.017586173,-0.008168739,-0.027714238,0.030567938,-0.06766091,-0.027871123,0.034745604,-0.016225506,0.020596555,-0.02525846,0.073721245,-0.04735107,-0.031726785,0.11078472,0.051494278,-0.0038865977,-0.05127922,0.033241816,0.015367678,-0.037591815,-0.0885833,0.0010475819,0.011584703,-0.00042976675,-0.038569428,-0.03548653,0.0042545814,-0.07219465,0.07741306,0.036840767,-0.04711981,-0.11320796,0.015816988,0.024821624,0.058166757,-0.01608052,-0.010580486,-0.021438519,-0.0065798927,-0.09552104,-0.0038532554,0.016689898,-0.049170207,0.0247862,0.015541502,-0.026065806,-0.019660877,0.050598074,0.0492936,-0.010050471,-0.007361507,-0.08055269,0.027814494,0.025118697,-0.0066274954,-0.0003125559,-0.007635905,0.05689385,0.068928964,0.04484425,-0.030997345,-0.0016070738,0.056688443,-0.0073713856,0.0383596,0.053122222,0.041882373,-0.0161643,-0.0024961145,0.023857243,-0.032146607,0.09248167,-0.03947205,0.06152237,-0.056139465,-0.049590252,0.03449743,-0.024090612,-0.007936359,-0.059792116,0.018815534,0.057858147,0.074995965,-0.017264389,0.019669209,-0.07265074,-0.014009911,0.026644183,-0.0023848654,-0.12029246,0.0695852,0.0036547913,-0.119946405,-0.072052084,-0.010534345,-0.057645556,0.0052246037,0.06539687,-0.047658425,-0.009039604,0.055948872,0.00040930364,3.1287406e-33,0.01953911,0.042977817,-0.0007999384,-0.018543523,-0.037890267,0.03058037,-0.11111589,0.005703292,0.01380813,-0.045300927,-0.10691135,-0.036189996,-0.047338966,0.11077536,-0.005705912,-0.05652123,-0.0035223104,0.0011806526,0.0684248,-0.022862205,0.029167034,0.06727822,-0.03620077,-0.02819633,-0.060035646,0.068598814,-0.01462777,0.0470432,0.06558218,-0.014368488,-0.015074756,-0.0719865,0.038189147,-0.014962275,0.0072973664,0.057392947,-0.06078539,-0.00066153496,0.048945636,0.046611622,0.02830506,0.027942233,-0.027819771,-0.035425253,0.070257396,0.019940404,-0.031044526,0.0075052483,-0.0072168866,0.09371557,0.026191588,0.028806202,-0.049552575,0.0040592584,-0.019104244,-0.0055321576,0.0004189583,-0.0074518574,-0.02205091,0.019444825,-0.029636033,0.044222854,-0.037995312,-0.07338872,-0.047463983,0.025363961,-0.058750533,-0.024996746,-0.058145873,-0.00090162986,0.0135214375,-0.0701675,0.06319364,0.03988904,0.1534926,-0.04201358,0.009979425,-0.0012502058,0.04518336,-0.046125922,0.008288967,0.03964433,0.033632148,0.08786347,-0.068673156,0.008043526,-0.00067617174,-0.04005346,0.0457352,0.08522228,-0.056386538,-0.05640986,-0.025327988,0.0018931966,0.021998674,-4.3261737e-33,0.07983235,-0.06673846,0.062032286,-0.053136498,0.03374881,0.090417095,0.051992014,-0.08823849,0.10013991,-0.016776066,0.10490393,0.05829759,0.0033057674,-0.049388163,-0.039351095,-0.017568761,0.001510578,0.0731206,-0.056564953,0.017743472,0.014264564,0.03059582,0.018323418,0.021970626,0.08098177,0.07141089,0.06703201,0.030316584,0.06099919,0.08570863,0.00052140193,-0.039866354,-0.048104525,-0.046643667,0.022366915,0.0010971562,-0.095106594,0.049993824,-0.09954347,-0.035142127,0.021433564,-0.0075330315,0.0015573199,0.0511311,0.090188146,0.008638241,0.004181896,-0.031656962,-0.040386826,0.020822119,-0.02395389,0.028746005,-0.07438107,0.030353978,0.042595476,0.0005134615,0.013009403,-0.042227402,0.026670802,-0.044832945,-0.07789851,-0.030039547,0.058301676,-0.05525877,0.08586976,-0.032347538,-0.013253133,0.06527379,0.09161083,0.05852817,0.1060295,-0.07469331,-0.019629292,0.062635355,0.04801349,0.017762126,-0.037427466,-0.12769872,-0.09543529,-0.05571058,-0.02042463,0.08203438,-0.005102455,-0.10585325,-0.0377821,-0.028673733,0.004252671,-0.037407406,0.037307415,0.09981299,0.01672663,0.0356987,0.035577767,0.011903521,0.057837434,-4.2290893e-08,-0.0228103,-0.03876158,0.07227817,0.016417222,-0.04465096,0.006268565,-0.018285783,-0.018850911,0.05000275,-0.0426967,0.024959542,0.095028944,0.03464211,-0.040650763,-0.033387043,-0.039967947,-0.040805135,0.016174218,-0.015365913,-0.016008323,-0.17842497,0.017216804,-0.055979364,-0.014011423,0.008494981,-0.07472238,0.0053727385,-0.027976148,-0.019251455,-0.00936688,0.0759676,0.07451928,0.053423792,-0.041957468,-0.03242014,-0.00547666,0.0041258605,0.050114464,-0.047731865,0.0098089045,0.019022247,-0.066132724,-0.06809095,0.010096982,0.0023770889,0.021739323,-0.04001875,-0.024356285,0.026387269,0.03881637,0.08569378,-0.032538418,-0.019216862,-0.086138174,-0.05781541,-0.0071523036,-0.07961492,-0.008594853,0.016968567,-0.16797662,-0.09841188,-0.0492751,0.21803531,0.020112904 +2.4.1.122,"The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T antigen. The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit.",384,0.99999994,-0.0672491,-0.024321256,-0.07297733,-0.047298215,0.0036401458,-0.016417196,0.008767886,0.11500931,0.067860775,-0.017351082,0.056274116,0.011687419,2.5769501e-05,0.10167538,-0.074399576,0.029411396,-0.014510194,0.02490948,0.081513524,-0.051769022,0.102514684,0.010091498,0.011543184,0.012804826,-0.017831886,-0.04482545,-0.012212264,-0.006821794,0.009026862,-0.06276199,-0.08781085,-0.03920509,0.0065332856,-0.04324861,0.059500687,-0.06919291,0.009161911,0.0041003637,0.0486913,-0.003986535,0.029283224,0.0031717077,-0.046602834,-0.032620434,-0.022533603,0.00084661075,0.08938162,-0.002757223,-0.01571217,0.022745658,-0.016581064,-0.03427729,-0.024366323,0.015563004,0.053701222,-0.029840475,-0.10689375,-0.018829703,0.05273972,0.011992755,0.0015282506,0.0023864491,0.057761256,0.021201322,0.021968054,-0.08619222,0.06299309,-0.06314962,-0.078041986,0.0032897019,-0.0280065,-0.08672441,0.006546369,0.05707379,0.003787149,0.07736617,-0.014566038,-0.0058144117,0.02898942,0.08751351,0.004486851,-0.0026302831,-0.021196643,0.064690344,-0.01304976,-0.026429882,0.04269528,0.020675197,0.08147778,0.03107542,0.0033242453,-0.08355043,0.021686964,-0.068397984,-0.009408506,-0.052076366,0.05858911,0.064755574,0.02564178,0.0035319764,-0.047988195,0.02889791,0.043538734,-0.05070578,-0.068965204,0.026759723,0.026071176,-0.006870774,0.046225864,-0.031061156,-0.039928816,-0.009523089,-0.015458822,-0.036222734,-0.08537668,0.01840728,0.042318814,-0.056806,-0.022482878,-0.004653859,0.019412126,-0.026188172,0.01589137,0.12353388,0.079517536,0.10566563,-0.03472899,1.4478543e-33,0.071186356,0.040647715,0.004285179,-0.0390096,0.00619069,-0.034032185,-0.0128499875,-0.020309053,-0.045955062,-0.04978839,-0.08219626,-0.0601522,0.050682016,0.07871384,-0.05188215,0.013169592,0.028667198,-0.058984205,-0.0074559897,0.01277109,0.00042077308,0.073175184,-0.003070029,-0.0047512692,0.027685564,0.044589955,-0.0780352,0.01137191,0.08556438,0.025795327,-0.011369269,-0.0777339,-0.11677616,0.036272846,0.07643426,-0.016876541,-0.028011987,0.014766435,0.06903476,0.030516937,0.021133488,0.034228817,-0.0011248727,-0.01609906,0.059908237,-0.030123297,-0.012495134,0.027032768,-0.022549685,0.056902677,0.03489709,-0.09032504,0.013708581,-0.05173265,-0.06734185,0.05550474,-0.048039507,-0.029084658,0.00040968673,0.08174386,-0.019701727,-0.028560864,-0.031654485,-0.030592436,-0.018881284,0.017979885,-0.093062244,-0.017470945,0.028571146,0.017317055,-0.0003631415,-0.057499293,0.031220999,0.049013935,-0.01169456,-0.04220082,0.03028038,0.026504407,0.041263524,-0.003539897,-0.018679319,0.012093846,0.03292185,-0.047402848,-0.022514936,0.010894196,-0.024240756,-0.0399926,-0.060627718,0.04294156,0.025208289,-0.065099426,-0.059569016,0.0670008,-0.030729866,-3.7992576e-33,0.11794649,-0.095354006,0.10259045,-0.05949771,-0.09116919,0.099143654,-0.02167535,0.022222968,-0.013527301,0.0042964392,0.042390667,-0.0767601,0.0026586324,-0.062131274,0.01868671,-0.05328957,-0.014121158,0.12014738,-0.072098695,-0.0062282183,-0.05120183,0.016374195,0.047949284,-0.07673171,0.019294428,0.03866236,-0.022711175,0.065005645,0.0069346507,0.033623636,-0.091765575,-0.029924832,-0.036330774,-0.02640359,-0.010632935,0.006579728,0.064540304,0.021669738,0.04167138,-0.029235816,0.046453826,0.0048646824,0.044918217,0.078667514,0.018895725,0.08599061,-0.031225542,0.009763641,0.007823141,-0.044926938,0.04762873,-0.027400155,0.033993095,-0.029925978,-0.028422462,0.052357033,0.038891386,0.0028808857,-0.0413208,-0.02700588,0.010231386,-0.060765132,0.014713785,0.017455336,0.07365756,0.069692925,-0.026853602,0.03294539,0.051786628,-0.071678616,-0.047655948,0.0056189327,-0.029495336,-0.07891827,0.0383214,-0.030213868,-0.14234026,-0.076474264,0.07951076,-0.032416485,-0.056328904,-0.026230257,-0.03928944,-0.062688954,0.030091846,-0.032122962,0.043156456,0.08817079,0.066397496,0.07478085,-0.03309993,0.024283726,-0.013481778,0.11116999,0.045476317,-4.074357e-08,0.08056113,-0.040972054,0.01831485,-0.0065933755,-0.03370203,0.027133374,-0.079969056,0.019099396,0.04523438,-0.0023290084,-0.0101386905,0.060164448,-0.017888334,-0.025959976,0.044667933,0.042533796,-0.11458391,-0.041214433,-0.015938077,0.01538551,-0.07485207,-0.017719008,-0.063581176,0.108993724,0.004539192,-0.009815707,0.015080993,0.08078746,-0.06314304,-0.05843029,-0.05004483,0.022319116,-0.1206024,-0.050136358,-0.1103903,-0.097284645,-0.007300637,-0.079258606,0.025667645,0.023641242,0.067885645,0.03255409,-0.07250562,-0.003603121,0.019233152,0.082242854,-0.034098897,0.021530068,-0.08860556,0.0018527097,0.027452158,0.001984279,-0.046736088,-0.0016098615,-0.14397532,-0.060913745,0.07506523,-0.08920118,0.011339938,-0.02753174,-0.009200506,0.028110096,0.19406614,-0.014683701 +2.4.1.123,An enzyme from plants involved in the formation of raffinose and stachyose [cf. EC 2.4.1.67 (galactinol---raffinose galactosyltransferase) and EC 2.4.1.82 (galactinol---sucrose galactosyltransferase)].,384,1.0,0.0331707,-0.042927723,-0.16017832,0.0711575,0.056045793,0.0914721,-0.052244883,0.035647556,0.055036828,-0.038441032,0.033997174,-0.012412078,-0.037804633,-0.014943443,-0.083612084,-0.022643045,-0.11368001,0.02618885,-0.012926957,0.0036508194,0.14981955,-0.0019988217,-0.028513342,0.068796925,0.10263746,-0.0997758,-0.050083797,-0.08818364,-0.04806504,-0.09750835,-0.0030444034,-0.01303131,0.13009882,-0.04739243,0.020671563,0.059707526,0.014821213,-0.10537128,0.045051,-0.031936437,-0.029976038,-0.035364117,0.0072416454,-0.049087502,-0.03508104,0.027313808,0.07051374,0.03254335,0.04117504,-0.06269406,-0.010205245,-0.09248115,-0.04861343,-0.057001907,0.082496345,0.060273226,0.009789367,-0.035976026,0.039841585,-0.021598134,0.07887763,0.04483623,0.008983681,0.0024634025,-0.04262852,-0.03902027,0.03448241,-0.022233544,0.07602789,-0.06593855,-0.04003035,-0.049004015,0.021922236,0.020496815,-0.03936092,0.09358176,-0.023212066,0.05440475,0.077265956,0.012087788,0.030947538,0.0059752385,-0.014433905,-0.03051616,0.0059943814,0.030446596,0.052042466,0.07180719,0.033916887,0.015565525,0.023500679,-0.07780328,-0.022714408,0.039813038,-0.06251958,0.018003577,0.10184406,-0.056439765,0.05545769,-0.046718314,0.0141967805,-0.0111292135,0.06149363,-0.039621666,0.007312378,0.05951779,-0.04578683,0.008867132,0.023650078,-0.00348604,0.00044064765,-0.011169853,0.008723355,-0.001245571,-0.08049846,0.08674479,-0.018984731,-0.07645032,-0.06465419,0.013544786,0.03241839,0.029844942,0.04787016,0.0316021,0.027304461,0.032463733,-0.08672157,1.8506974e-33,0.041954666,0.048274416,0.009365823,-0.004352831,0.039746854,-0.035641447,-0.076902375,0.022946676,0.008522942,-0.023186482,-0.123426065,-0.079996236,0.042027626,-0.024244541,0.028328037,0.026630463,0.029251501,-0.068052545,0.03834094,0.025521914,-0.10404829,0.026031675,-0.080781415,-0.019902129,0.030009773,-0.011247749,0.035109214,-0.040330023,0.09857102,-8.19725e-05,0.027117847,-0.082830235,-0.07127171,0.027908191,0.11320257,0.027630731,-0.012584023,-0.08701261,-0.023737703,0.032838583,0.0031258685,0.015240968,0.001533081,-0.030399783,0.04810338,-0.053818896,-0.048005864,0.035769027,0.10848174,0.06502802,-0.04369682,0.002822428,0.058765717,0.033188492,-0.009487965,0.049347416,-0.02055818,0.020289123,0.06415032,0.04788407,-0.02503577,0.009375633,-0.062506855,-0.0017113684,-0.00027789423,0.05187353,-0.09118078,-0.009123484,0.00444216,0.026644187,-0.05768338,-0.09708895,0.028335435,-0.010091389,0.0219181,-0.018498495,-0.016767094,0.030260272,0.043999057,0.028083257,0.020873467,0.05274422,-0.035899293,-0.05169588,-0.018340949,0.020703766,-0.05162188,-0.024115743,-0.012028743,0.10782169,-0.044194907,-0.040277954,0.031903632,-0.011744942,0.042482756,-2.9894294e-33,0.111803934,-0.07306186,0.05389716,-0.06897822,-0.015070891,0.08635156,-0.010960737,-0.07474015,-0.032299675,-0.020979114,0.035825524,-0.02080179,0.042970467,-0.07505565,-0.012390631,-0.04130764,0.041580457,0.081825845,-0.032464556,0.022453584,-0.013381148,0.08468176,-0.02164499,-0.029645795,-0.0003300902,-0.053225115,-0.0025589566,0.11030964,-0.043447733,0.009996502,0.055586208,-0.06417125,-0.04491966,-0.009596826,-0.06344649,-0.05852075,-0.008142355,0.021979358,0.05751849,0.030920966,-0.017555257,0.069862336,0.035014223,0.025214551,0.09006925,0.03985422,-0.081322804,0.011514848,0.070881486,-0.043375026,0.020563796,-0.022744864,-0.056938305,0.05378661,0.022255614,-0.03720392,0.029140888,0.050900884,0.038922045,0.006269053,-0.037338674,-0.06645911,0.046168875,-0.016422298,0.052267104,-0.008789023,-0.061479736,0.044388354,0.029371247,0.039117146,0.061360765,-0.016064394,0.016864268,0.11584682,-0.029046623,-0.036389083,-0.10534839,-0.046940316,-0.0011817702,-0.07204031,0.09159747,0.008730471,0.04154289,-0.05143211,0.005673174,-0.046109352,0.06915966,0.0882492,0.01265863,-0.001346935,-0.05252178,-0.025164107,0.0038201483,0.0046548545,0.1499578,-3.941352e-08,0.012436615,-0.0038021684,-0.010261302,-0.082650885,0.016118184,0.002140068,-0.010378991,-0.02579794,0.015797751,-0.09031808,-0.033761326,0.07584878,-0.035460327,0.015151194,-0.009242705,-0.014373429,0.004180405,0.063340224,0.027608888,0.060329158,-0.030949952,-0.021072758,-0.10290617,0.029636273,0.01954982,-0.051650535,0.08190127,0.07315348,0.014693242,-0.05620147,0.034594364,0.02710355,0.026445022,-0.060593773,-0.111346416,0.013402614,0.004928463,-0.00082399166,0.019659141,0.059247546,0.025376469,-0.03452262,0.008876261,-0.026196262,-0.07482823,-0.011140715,0.0022217873,0.037964754,-0.03360039,-0.011419848,0.064188324,-0.041189995,-0.055722672,-0.06470872,-0.0348388,-0.029560238,0.030121163,-0.04808058,-0.014672743,-0.020171111,0.021978214,-0.044672456,0.12778886,-0.02263728 +2.4.1.125,"The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends (1->6)-alpha-D-glucans by both alpha(1->3) and alpha(1->6) linkages, with one of the linkage types being dominant. cf. EC 2.4.1.140, alternansucrase.",384,1.0,-0.056543574,-0.10950763,-0.03771238,-0.0016287598,0.07004927,-0.0044349474,-0.028201664,0.03577232,0.038189378,-0.0030728928,0.037736002,0.09656709,-0.0053390563,0.017853063,-0.14053757,-0.0027093494,-0.06944167,0.016548466,-0.08679368,-0.04137818,0.15567522,-0.0120655475,-0.021613507,-0.023971882,0.093366005,-0.07295739,0.028085068,-0.027821904,0.010454879,-0.060282066,-0.07899308,-0.07112487,-0.029772064,0.0365922,0.043948505,0.05050515,-0.03651971,0.03437443,0.032722037,0.010360279,0.027912779,0.004103521,0.015696324,0.046850096,-0.059297476,-0.033213962,-0.1388444,0.08657725,-0.03743345,0.042157326,0.011660564,-0.02694287,-0.0838286,0.07337806,0.011320646,0.034361318,-0.032111265,-0.01671085,0.044556454,0.06612601,0.07429836,0.029427541,-0.046441086,-0.06403169,-0.0057756975,-0.058536295,0.08269543,-0.0005994056,-0.05282725,0.0045967638,-0.019854156,0.0018012612,-0.003500747,0.04905589,0.045698874,-0.021952808,-0.0369118,0.03798687,-0.025005806,-0.05945217,0.07680359,0.006029916,0.083645485,0.07346822,0.016233508,0.006989684,-0.023717877,-0.015411546,0.01629924,0.017937517,0.05873528,-0.06706456,-0.024179548,-0.079490125,-0.003229428,0.019123131,-0.030289097,0.031046217,0.101889014,-0.06296865,0.010150639,-0.0034823616,0.040508386,-0.038247783,-0.05683879,0.040449116,-0.03508085,0.07753969,0.0655246,-0.027266197,0.010271034,0.033183843,0.028063156,-0.0107056545,-0.07750851,0.009262216,0.043579966,-0.011289322,-0.0784915,-0.011754644,0.04238547,0.07113956,0.13522744,0.06061333,-0.05698371,0.028316189,-0.089872435,-1.190139e-34,0.07522213,0.00485538,-0.0076463134,-0.015930833,-0.037894856,-0.015702663,-0.101654604,-0.01613578,-0.07323174,0.060187746,-0.11269579,-0.021521436,-0.046452273,0.050716598,0.00605264,0.06360857,0.032474745,-0.021583391,-0.016713254,-0.061330885,-0.007546226,0.104070194,-0.02099535,-0.022978617,0.02911249,0.025520952,-0.07720856,0.057263512,0.04096567,-0.027221292,-0.0017255472,-0.037358273,-0.05132274,0.08442331,0.04939671,0.025842663,0.018000871,-0.03507527,0.046021402,-0.032880437,0.016570996,0.02283133,0.051745493,-0.08015648,0.08158055,-0.013116026,0.00029491508,0.052216336,-0.030025808,0.05856793,0.016539423,-0.017546156,0.072508,-0.0123917125,-0.053450443,0.0222564,-0.01728729,0.014931412,0.06663753,0.06934875,0.027134731,0.020721056,-0.02486918,-0.032653324,0.026926233,-0.010553846,-0.09373642,0.008277607,-0.026796471,0.105306596,-0.07557679,-0.0043517314,-0.048878007,0.07188537,0.04652374,-0.070186526,-0.106108926,0.028641032,-0.007849652,-0.003815315,-0.046805464,-0.0108031295,-0.04806562,0.0060137156,-0.10709582,0.01857517,-0.073811,-0.13226609,0.0137864975,0.06458499,-0.0013936647,-0.011150263,-0.050555438,0.07102786,0.065236926,-2.6155947e-33,0.07646643,-0.054315567,0.07466026,0.016319532,-0.05368105,0.05934006,0.036877014,-0.009160987,0.0023508219,-0.029174974,0.03540456,0.056513306,-0.09700117,-0.06361712,0.024823165,0.015345118,-0.07319164,0.10496047,-0.027358707,0.014462871,-0.00047502868,0.11774516,0.03667554,0.011292774,0.07288007,-0.039768312,0.0795853,0.09436461,0.009752473,0.009721614,0.00027566202,0.019130995,-0.0015360877,-0.007605977,-0.0712454,0.0017462969,-0.008693645,-0.006935319,-0.0020254252,0.0057537192,0.009433968,0.055852216,0.019106451,0.011219069,0.075014986,0.021937909,-0.061453782,0.022738185,0.00900518,-0.086897835,0.025902102,-0.02866867,-0.0042287474,0.010160345,0.05951914,0.025685497,0.06567059,0.04351781,-0.063144274,0.01165653,-0.026358414,-0.0034444018,0.009513225,-0.04334535,0.08341055,-0.036884025,-0.011337469,0.027676776,-0.009433969,0.05058283,0.0014924009,-0.047629002,0.0077983574,-0.060056273,-4.81418e-05,-0.117750615,-0.07395465,-0.023291837,-0.028450595,-0.09053762,-0.013136774,0.0034513175,0.03747634,-0.017998107,-0.023050291,-0.022400534,0.05960591,0.08919695,0.027469132,0.041991483,-0.08325877,-0.017839212,0.0025232825,0.018352391,-0.006021777,-4.5088296e-08,0.018279007,0.013593143,-0.048484206,-0.06971709,-0.003213297,0.012184798,-0.077278234,0.07305415,0.008087759,0.026562719,-0.046974815,0.1033678,-0.021056868,0.018605363,-0.0225245,-0.04025712,-0.010369874,-0.012085711,0.0018839102,0.014680402,-0.077293426,-0.02802213,-0.095974475,0.07417231,-0.010507528,-0.108103335,0.026360335,0.12905137,-0.01921112,0.04223237,0.014883622,0.015572875,-0.04975449,-0.04271752,0.011539433,0.052259285,-0.07786152,-0.025371252,0.02206089,0.04540942,0.0800235,-0.005310546,-0.05535368,0.022469701,-0.0269943,-0.08175132,0.015804607,-0.036541745,0.006061608,0.08045214,0.016467756,-0.021382444,-0.06643385,-0.06172116,-0.022519752,-0.044966128,0.02893058,-0.008179431,0.02292882,-0.07145651,0.029961467,-0.023258857,0.120580964,-0.037430104 +2.4.1.126,"Acts on 4-coumarate, ferulate, caffeate and sinapate, forming a mixture of 4-glucosides and glucose esters (cf. EC 2.4.1.120 sinapate 1-glucosyltransferase).",384,1.0,0.003553899,-0.05563548,-0.07148252,0.07267451,0.03466385,0.043351527,0.026176613,0.04043816,0.04220478,-0.007203543,0.003939744,-0.066633575,-0.057022896,0.020554505,-0.010357873,-0.09220044,-0.034821004,-0.007258336,0.02010046,-0.02858372,0.1123199,-0.046088926,0.01820906,-0.04174394,-0.0045787212,0.09260666,0.061781302,-0.09552292,0.040330373,-0.057739053,-0.054020785,0.018105354,0.023883678,-0.0431581,-0.032483768,0.105987824,-0.035575073,-0.07184575,0.01593822,0.028054394,0.020477587,-0.0054141134,0.06453243,-0.0041341917,0.0042688902,-0.100782536,0.020346664,0.012718968,0.047458597,-0.0041675256,-0.04449069,-0.0049013696,-0.10108744,0.0382289,-0.0027871458,-0.040271796,-0.077930965,-0.037672944,0.06899213,0.07024824,0.039072994,-0.026844578,-0.014954741,0.050739855,-0.013885172,-0.008974837,0.05714884,-0.042806614,-0.041168794,-0.049249668,-0.04876152,-0.028770844,0.04395307,-0.01028312,-0.016882576,0.043003324,-0.050738726,0.055206694,-0.0035229572,-0.00022512063,0.07248259,0.018293986,0.11477915,0.056961745,0.052162156,0.05315849,0.003014224,-0.005532712,0.030694792,0.0068508354,0.011923555,0.017288411,-0.008706282,0.06531806,-0.032029036,-0.00020788306,0.0034017253,0.011513452,0.089705296,-0.0066605,-0.033944756,0.05129673,0.025871316,0.01173139,-0.049299315,0.019998468,-0.018485932,0.09784304,0.01783051,0.07412033,-0.034699533,0.07364882,-0.041491833,0.014887354,-0.04035456,0.08833692,0.004449236,-0.06761627,-0.03140072,0.054938212,0.04364531,-0.054293584,0.054660592,-0.019104991,-0.00082671054,-0.03696205,-0.025043912,2.7468548e-33,0.080209754,0.011395498,0.030599924,-0.018820899,0.01666376,-0.025257323,-0.0693355,-0.035171807,0.003491978,0.0614148,-0.053254347,0.009817896,-0.0025404878,0.07623656,-0.0027465052,-0.015959907,-0.035491176,-0.02367527,0.10803932,-0.05320041,0.045821752,0.11661895,-0.034821704,0.035242077,-0.053441364,0.09625785,-0.05853015,0.05428936,0.005568725,-0.017648198,-0.044947606,-0.08273722,0.001087031,0.001955786,0.03162624,0.017809222,-0.07642877,-0.015670203,0.007735033,0.08352104,0.010678116,-0.0013067242,-0.013472071,-0.09726781,0.057992525,-0.07195858,-0.052682288,0.07291336,0.02797122,0.15577891,-0.0016513766,-0.023120692,0.06433996,0.0676985,-0.07145668,0.020173308,-0.045531273,-0.083541125,0.00032621797,0.022589616,0.028073149,-0.0052263457,-0.0024124575,-0.06582435,-0.030120024,-0.010840598,-0.08778238,-0.05453737,-0.015574739,-0.0076669944,-0.008470242,-0.037655942,0.04428233,0.032030832,0.08916564,-0.05967559,-0.025819264,0.082615115,-0.055533856,0.0014457991,0.028181566,0.010429142,0.029081918,0.037485797,-0.060353756,0.07299226,0.014936104,-0.07397235,-0.017642181,0.020078823,-0.0585982,0.03804135,-0.03346025,0.014183782,-0.0051592896,-3.8172794e-33,0.072065115,-0.029765377,0.0498668,-0.052078985,-0.08184717,0.045839377,0.046655647,-0.09462307,0.019353036,0.036052234,0.080204286,0.035174668,0.059106514,-0.10859131,-0.06373026,0.064582564,-0.0121888025,0.03123806,-0.066717856,-0.012836253,-0.026668658,0.0667763,0.032855272,0.0060189767,0.083715715,0.030142274,0.12733364,-0.06223042,0.014363474,0.09724251,-0.021770107,-0.0755464,-0.030504419,-0.022648271,-0.033930007,-0.048956744,-0.007499486,0.03828333,-0.055308484,-0.025180085,0.013091237,0.07560338,0.079064995,0.059328675,0.07330407,0.0015105833,-0.027180664,-0.008071814,-0.08825119,-0.005317052,-0.0035211698,-0.011600804,-0.09459617,0.0067683565,0.0047880155,0.017201694,0.053410172,-0.03801938,-0.05308716,-0.0021498888,-0.0466733,-0.035385553,0.030685421,-0.062852114,0.1620927,-0.028533606,-0.060829494,0.0052738967,0.05618068,0.1122784,0.07930106,-0.050368533,-0.011594162,0.014373706,0.020210369,-0.010998411,-0.035418913,-0.10587966,-0.086299665,-0.075049385,0.020903755,0.014959054,-0.01821317,-0.10804121,-0.09743088,-0.07210486,0.0151581485,0.06449631,0.058235828,0.07746277,-0.065307915,0.0236152,0.028110882,0.027646655,0.048311375,-3.673055e-08,-0.037112895,-0.017512875,-0.015614262,0.005561671,-0.044672575,0.015218764,-0.022426253,-0.06467971,0.058062915,-0.031196693,-0.034180295,0.11148617,0.0041142693,-0.022483572,-0.024063326,0.016969254,-0.056358907,0.08556558,-0.023362601,-0.021656018,-0.071806446,-0.035993204,-0.02354401,0.0047759023,0.05211208,-0.10454523,0.042903487,0.025732335,0.017832862,0.04037053,-0.004373051,0.035733107,0.022206591,-0.10463376,-0.08204285,-0.022111438,0.008638625,-0.008301682,-0.039183162,0.01968796,-0.020810988,-0.04818926,-0.03754822,0.02054811,-0.019407466,0.03925357,-0.058111392,-0.0023043342,0.039789632,0.0383697,0.004610898,-0.008533132,-0.052395836,-0.056793243,-0.056712292,-0.026328748,-0.008836309,0.025049897,0.077967584,-0.123481005,-0.04882122,0.004053343,0.09989103,-0.044107262 +2.4.1.127,(+)-Neomenthol can also act as acceptor.,384,0.99999994,-0.008226834,0.008162322,-0.032305364,0.011683427,-0.002042851,0.009060143,0.09574934,-0.08554603,0.0006747678,-0.018000316,0.040137466,-0.04406154,-0.023148526,0.04439824,0.0038166775,0.020746639,-0.06442244,0.046157558,0.012312405,0.031364176,-0.037937913,-0.05499895,-0.0025718277,-0.03439912,-0.0024819802,-0.011893238,-0.031671163,-0.085947014,0.09279921,-0.026647376,0.013810202,0.036253728,0.0037006128,0.049278796,-0.059371505,0.025165437,0.0016364795,0.02197516,-0.07995089,-0.0054959054,-0.016310873,-0.05873699,-0.017040696,-0.044299074,-0.051033586,-0.044603013,-0.054668695,0.009833758,-0.0333586,-0.041393362,-0.042314995,-0.005276911,-0.075781845,0.064799204,-0.01955779,0.02165927,-0.0149579,-0.034197252,0.0059502483,-0.015092653,-0.0087565575,-0.037832543,-0.09364038,0.049818598,0.060056165,-0.028565377,-0.022257697,0.026133303,-0.120184705,0.08810694,0.018597439,-0.009528545,0.010973128,0.0019140912,0.0054262774,0.020781863,-0.036240004,9.828657e-05,0.045894384,0.018163184,0.0016039325,0.06324175,-0.015894402,0.007335749,0.07122603,0.0604052,-0.08522322,-0.01664169,-0.022629537,0.07066779,-0.054642323,-0.0044302098,-0.014385113,-0.018557142,0.036351845,-0.030083437,0.07421814,-0.017727032,-0.032930408,0.023674933,-0.013322934,0.03587138,-0.07213936,-0.040610105,-0.050471604,-0.04932485,-0.008442174,-0.040113147,-0.028588029,0.0035733443,-0.08783056,-0.10077631,0.10604952,-0.0325443,-0.003336497,0.07493341,0.029350648,-0.050411724,0.060664356,-0.050428126,0.014867736,0.08272151,0.010409746,0.051672254,0.018065471,-0.010406698,-0.0019710101,-2.448174e-33,-0.023484362,0.05724375,-0.024989411,0.028508885,0.02508056,0.0757575,-0.08107892,0.01003258,-0.051966906,-0.07324422,-0.011150012,-0.0033463105,-0.022758493,0.09561604,0.022626584,0.04082742,0.05931464,0.049081072,-0.0026334408,-0.09060989,0.006224837,0.11384086,-0.067256585,0.05633299,-0.039417386,0.01233407,-0.006106814,0.01878477,0.0023077815,0.018617166,0.06372546,-0.004222151,-0.041615035,0.11896175,-0.007947864,0.087273695,0.0048979484,-0.032226495,-0.047509816,-0.12060156,-0.06305453,0.045036267,-0.024573725,0.03743287,-0.02192931,-0.06081658,-0.011671585,-0.030052295,-0.023565076,0.037792943,-0.059489254,0.11171383,-0.014970017,-0.042599663,-0.07105145,0.034194134,-0.0003368577,0.13199146,-0.027276129,-0.0051541436,0.0427114,0.10778032,0.034600396,-0.021548187,-0.04949672,-0.0002533943,-0.03318291,-0.038053066,0.06530934,0.032886952,-0.0793066,0.08249094,-0.0038074933,0.113342255,0.031524207,-0.07358633,-0.023231097,-0.03968083,0.029413246,-0.045872767,-0.174759,-0.02398751,-0.010670237,0.07736323,-0.03808769,-0.066020355,0.06552093,-0.06058402,0.05471988,-0.010804971,-0.03350639,-0.07182632,-0.049774315,0.04401531,-0.030063795,-7.849493e-34,0.044529215,-0.060451362,-0.01974192,0.034759548,0.011723504,0.026539171,-0.036047768,-0.12096199,0.07911469,-0.019667208,0.055443853,0.0697627,0.064157926,0.020054419,0.04061957,-0.03787982,-0.0012468632,0.024433892,-0.009855251,0.003555296,-0.029692838,0.08311748,-0.061393477,0.06254089,-0.0058573685,0.043036647,0.026362587,-0.008037324,-0.0060668294,0.03114095,0.0066265566,-0.008877921,-0.07304602,-0.03740059,-0.010672574,0.019049214,-0.03635256,-0.018238882,-0.07175209,0.008387223,0.03335384,-0.060429573,-0.016770875,0.08564112,0.057700306,-0.08118004,0.015699042,-0.0060121785,0.004116764,-0.041376587,0.014695852,0.030075649,-0.0018032725,0.019909687,0.09637478,0.054621756,0.07725922,-0.094494395,-0.023924666,0.009229919,-0.034841977,0.040912643,0.011644668,-0.022144519,0.04587672,-0.059183322,-0.08621145,0.041417394,0.048935797,-0.064889885,0.17303257,0.029369114,-0.056724552,0.10589316,-0.014754271,-0.12973455,0.028525913,-0.029643187,-0.01540307,-0.019850384,-0.103591226,-0.016315978,0.07206924,0.009827153,0.0045042546,-0.055189833,0.014602894,-0.021607624,-0.011104754,0.032469608,0.047657575,0.076179475,-0.05015131,-0.00033489955,-0.019587835,-2.2760235e-08,-0.072395414,-0.06398038,-0.012581289,-0.06759121,-0.027998224,-0.040441383,0.04201023,-0.08121996,-0.10043644,-0.00044776077,0.04381341,0.031452738,0.0839046,-0.06417975,0.06734952,-0.005596206,0.057750408,-3.628332e-05,-0.10275368,0.00084135146,-0.045564424,0.038087178,0.0017341652,-0.04210464,-0.080038846,-0.0016674566,-0.015176661,-0.025041811,0.0129940715,0.036357712,0.021141136,0.09154529,-0.028121162,0.0063105794,0.002376492,0.08241191,0.038503017,-0.018945662,-0.014758106,0.087688446,0.029607035,-0.03128519,-0.042773962,0.005619317,0.022643842,0.037485376,0.0035019282,-0.07446383,0.006791303,0.0005156026,0.08240933,0.049253855,0.06262338,0.041989926,-0.028886763,-0.04958736,-0.026678003,0.045528404,0.013872562,0.032049302,0.09418466,0.032318104,0.16581391,0.02945799 +2.4.1.129,"The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here). Involved in the synthesis of cell-wall peptidoglycan.",384,1.0,-0.030316144,-0.049489465,-0.07168811,-0.007625864,0.05315682,-0.048874624,-0.06254034,0.08509313,0.065727256,-0.011063861,0.010417056,0.019743958,0.048918203,0.05665082,-0.073346876,0.053849917,-0.009361462,0.0073680407,-0.0052296035,-0.037535094,0.07522006,-0.015079792,-0.043981183,-0.029587293,0.034721695,-0.015197393,0.025047557,0.037785355,0.08616639,-0.100674205,-0.0049087415,-0.051171854,0.036735766,-0.050059654,0.04580877,0.050100558,-0.051467244,0.010701281,0.052790668,0.055469595,0.021897415,-0.013386337,-0.042229313,0.00653805,0.035006203,-0.052249502,-0.09233465,0.102506064,0.04932409,-0.007752171,-0.009262508,-0.017338062,-0.05405107,0.058196317,-0.023306405,-0.0031214936,-0.111551546,0.05923757,0.034146316,-0.0009890025,0.05454184,0.09927339,0.02901301,-0.033989858,0.008395291,-0.08538271,-0.025603862,-0.025372632,0.06933045,0.037257805,-0.038327392,-0.075636454,0.022527874,0.014278221,0.1033991,0.02942502,-0.034112465,-0.0131915575,0.0012166401,-0.02221775,0.05188637,-0.022500204,0.021762729,0.05376738,0.024361078,0.02930911,-0.017901776,0.019529236,0.0067407815,-0.029933767,0.05023385,-0.048708614,-0.047427442,-0.05063359,-0.031027488,-0.040877912,0.008601474,0.047952026,0.010752534,0.006829458,-0.0031023335,0.01053527,-0.116027296,-0.086429305,-0.07577774,0.013008395,-0.010383708,0.047258582,0.09869885,-0.013694639,0.0040297764,-0.008009303,0.038454007,0.040196735,-0.003005771,0.10969992,0.008712437,-0.06051151,0.0012052872,-0.026699428,0.012631085,0.0123647135,0.00081131404,0.051217742,-0.09575901,0.0629769,-0.023805777,1.3790978e-33,-0.029135088,0.0415674,-0.013165501,0.0068763345,-0.02751888,-0.0054976977,-0.048592586,-0.006958898,-0.008921913,-0.0133691905,-0.061444607,-0.028076485,-0.0053986907,0.031121908,-0.033400275,0.0075586135,0.048457947,-0.047476947,0.030266576,0.050975896,0.044085007,0.058424134,-0.024126686,-0.020224482,0.079862885,0.09371818,0.017139796,0.015530021,0.08238507,0.015518359,-0.011957867,-0.0781091,-0.09369611,0.012112737,-0.058244083,-0.03845496,-0.04980618,-0.029083636,0.0027436207,0.023828618,-0.0071882666,0.059285298,-0.022674592,-0.06109923,0.08602466,-0.077599615,-0.002993525,0.13398644,0.04672977,0.0034308506,0.0852055,-0.012094416,0.045747355,-0.06775,-0.110820465,-0.002135923,-0.025529893,-0.0176368,0.0849595,0.06480056,0.09627046,0.04030935,-0.041299265,0.020439804,0.014989534,0.03744482,-0.043340977,0.03447432,0.016053371,0.03902312,-0.08291469,-0.028964918,0.057610665,0.058930647,-0.0051766685,-0.055640135,-0.02252607,0.053072136,0.04851917,-0.04396134,0.046686467,-0.001045346,0.03639651,-0.021542417,-0.015749993,0.025857395,-0.005185817,-0.082275204,-0.04407898,0.10165303,0.050331812,-0.073403545,-0.06601932,0.035065796,-0.016461357,-3.0316209e-33,0.10706608,-0.10641684,0.0078422725,-0.03822979,-0.07562574,0.06911497,0.00052572245,-0.0040870924,0.08225957,-0.0042294287,0.0491417,-0.0022648901,0.01685277,0.008057222,0.051819358,0.03794203,-0.051870007,0.033348177,-0.06466596,0.029854868,-0.053303942,0.042138286,0.00080408936,0.0044797165,0.029322414,0.029715637,-0.0004795047,0.00056886615,0.028314853,0.03693136,-0.024390955,-0.007958443,-0.09373148,-0.082634345,-0.06902749,0.01807283,-0.068472035,-0.061178464,-0.045394287,-0.022635711,-0.017514216,0.053406674,-0.04122179,0.06763297,-0.025419734,0.108795635,-0.050261963,0.0013118865,0.034731817,-0.06522086,0.023208255,-0.047942806,-0.0074944273,0.050037805,0.008895714,0.042143922,0.02181964,0.04047628,-0.012295122,0.014994656,-0.030607956,-0.061586667,-0.053772207,-0.053009637,0.06679897,0.08175,-0.026515195,0.06378285,0.04625397,-0.03338424,0.102036156,0.04273617,-0.010524527,-0.021772524,-0.04014393,0.0759887,-0.048246436,-0.096554846,0.0007451822,-0.06704388,-0.060208783,-0.025678566,-0.047443837,-0.07826681,-0.0035818995,-0.090751655,-0.004127448,0.16946602,-0.0145807145,0.042977963,0.051234037,-0.022918224,-0.024091005,-0.02895887,0.13154168,-4.283429e-08,0.024813617,-0.093486644,-0.0017894609,-0.041761167,-0.05402979,-0.04398772,-0.031163044,-0.011921398,-0.010410143,-0.0020508505,-0.01980532,-0.01285868,-0.014229046,-0.06462945,-0.020492537,0.087847635,0.03484272,0.083180346,-0.012970291,0.01921955,-0.12392993,-0.0028930146,-0.07105813,0.0005825305,0.080929264,-0.12883937,0.013804568,0.031071927,-0.056751218,0.0058341795,0.0016395695,0.014361698,-0.046702966,-0.04454231,-0.041717872,0.037792824,-0.01308098,-0.029351898,0.0007747136,-0.047250666,0.069749445,-0.0031057748,-0.082432374,-0.015141924,-0.012288466,-0.010348988,0.013608202,-0.03892825,-0.04591029,0.011528277,0.0039394097,-0.025081173,0.020972613,-0.06629954,-0.030025277,0.0049332962,-0.044704594,-0.049386963,0.04162921,-0.08750068,0.024801498,0.059561975,0.21543424,-0.05453054 +2.4.1.394,"The enzyme, originally discovered in lactic acid bacteria but later found in other organisms, is similar to EC 2.4.1.395, reuteransucrase, yet is not able to act on sucrose. The enzyme, which belongs to the glycoside hydrolase 70 (GH70) family, possesses both hydrolase and transglycosylase activities, cleaving alpha(1->4) linkages from the non-reducing end of linear maltooligosaccharides and synthesizing linear alpha(1->6)-glucan chains. It also possesses an endo-alpha(1->4)-glycosidase activity. Due to its narrow binding groove, it is not able to act on branched substrates. cf. EC 2.4.1.396, 4,6-alpha-glucanotransferase (linear and branched substrates, branched products).",384,1.0,0.019854516,-0.10413345,-0.079932086,0.01596255,0.034650855,0.0014410652,-0.07871397,0.04112141,-0.023048999,0.007974599,0.018257227,0.04273037,-0.07656299,0.09862269,-0.0762256,-0.04126435,-0.064412735,-0.028051306,0.009330079,-0.02442819,0.10947484,-0.005777871,-0.05783529,0.014151337,0.04877782,-0.021334842,0.028251804,-0.042385433,-0.033448644,-0.068701595,-0.02969895,-0.12263125,0.032567803,0.03493535,0.017680326,0.10042701,-0.025273405,-0.04579069,0.0016980276,-0.011051747,0.011518455,-0.07115727,0.03284481,0.021867983,-0.03790322,-0.057496242,-0.021093622,-0.02174593,0.0145406965,0.011840702,-0.050513748,-0.08029826,-0.04290931,0.032776456,0.036012113,0.004936434,-0.024575531,-0.005635335,0.0365116,0.04179488,0.05351834,0.021948462,0.0003014125,0.003684945,-0.08609487,-0.051109757,0.079190165,-0.05798447,-0.06049789,-0.016634285,-0.03206636,-0.0396324,0.01665901,0.03952899,0.08232144,0.03053665,-0.009701705,-0.001535018,0.018048676,-0.035591826,0.073307246,-0.041929018,0.023740038,0.075064234,-0.06006506,-0.036949623,0.040207513,-0.019534135,0.06538442,0.023794359,0.029634194,-0.026926104,0.01905421,-0.09185267,0.0065968693,0.051277153,-0.028474407,0.007702815,0.03494562,-0.067613274,-0.04179723,0.041444696,0.005103541,-0.056374095,-0.06636468,0.08038742,0.00799583,0.118244044,0.052995916,0.021821734,-0.014485887,0.037594233,0.08342066,0.0020515095,-0.022517473,0.02665686,0.05537179,-0.060435474,-0.07219783,0.009002132,0.037503205,0.008490225,0.1374167,0.031045236,-0.021189576,0.09022282,-0.037861675,5.68594e-34,0.07525108,-0.008767787,0.012156915,-0.07214419,-0.009796567,-0.029618619,-0.07990407,0.010611784,-0.06416287,-0.015693074,-0.02776092,-0.05389617,-0.025093136,0.07590216,0.030542389,0.04490374,0.044380948,-0.037045334,-0.010624981,0.045040816,-0.030736411,0.04978824,0.027331209,-0.015380227,0.04512634,0.06594846,-0.040966775,0.050200704,0.033556607,-0.023749143,0.024843825,-0.021279998,-0.08908794,0.08038185,0.064366974,0.026951537,-0.028079655,-0.0439544,0.032543328,0.029164094,0.024789363,0.049488287,0.047711205,-0.10129287,0.08260935,-0.01813716,0.002386061,0.0763922,0.043309595,0.061036382,0.019443614,0.021627689,-0.0020975964,0.038884528,0.018098634,0.04260934,-0.038756642,0.06739092,0.056881797,0.016628753,0.004086065,0.0788416,0.0036601606,-0.009706654,-0.026306832,0.022087349,-0.05009338,-0.01365143,-0.054448478,0.043459613,-0.0473815,-0.021420559,0.033102166,-0.0016852842,0.04322269,-0.08350129,-0.02894499,-0.005567252,0.024804346,-0.03852586,-0.029489182,-0.020275608,-0.025455799,-0.009916679,-0.07982755,0.030392988,-0.040829465,-0.035623167,-0.032517854,0.071880594,-0.057173464,-0.010485153,-0.06259692,0.08235797,0.0013456895,-3.2108312e-33,0.11359507,-0.12417661,0.06456258,-0.038234808,-0.04726118,0.0551429,0.022734616,0.0024380772,-0.0143444,-0.07265823,0.062136576,0.00642271,0.015897017,-0.042038094,0.06542189,0.010703012,-0.04508236,0.081476815,-0.004418796,-0.02968174,0.017984554,0.12554355,-0.040383372,0.06552489,0.14762262,-0.050306223,0.0010976262,0.123737596,-0.025988927,-0.008268242,-0.032447506,0.0035491043,-0.0069050337,-0.06342973,-0.054920446,0.020483805,-0.05909002,-0.02739376,0.036910787,-0.018244762,0.03810834,0.0724772,0.0126915155,-0.0019007286,0.058860667,0.099870116,-0.02582668,0.02784207,0.032027494,-0.049189337,0.0091519905,-0.037719045,-0.034726176,0.021650534,0.031252675,0.06267077,0.011200965,0.0455583,0.009922795,-0.0759471,-0.030508861,-0.03784676,0.036093522,-0.058173053,0.08405179,0.0032620803,-0.047008235,-0.012387354,0.009109622,-0.0036171568,-0.018656617,-0.07773882,-0.0123840645,0.055014566,0.016151926,-0.01124913,-0.117218494,-0.09699933,-0.03782625,-0.042721156,0.04347647,0.07335184,0.013727373,-0.031074207,0.09335657,-0.043279614,0.018149076,0.074036404,-0.0034242999,0.030850487,-0.06019307,-0.013029718,-0.06024608,0.015152837,0.09390936,-4.62007e-08,0.032549426,-0.015767511,0.014452644,-0.10069518,-0.0012426062,-0.037375607,0.0025971928,0.014344844,-0.001489934,-0.0662131,-0.031523295,0.08988667,-0.01063072,0.054589715,-0.011040446,-0.01993162,-0.050114684,-0.0055165878,-0.025957512,0.048577305,-0.102586485,-0.09960109,-0.16057138,0.06388397,-0.06416846,-0.08965159,0.009805011,0.08851333,-0.07019401,-0.07493734,0.012268976,0.038890112,0.034131013,0.011017519,-0.025237467,0.0011387409,-0.043071814,-0.018420547,0.01220704,0.030906217,0.066344135,-0.042105094,0.010075749,0.009384831,-0.072841324,0.0014985976,0.008318572,0.015025077,-0.03698117,0.05302136,0.07006745,-0.036650423,-0.034567147,-0.075525135,0.0105144875,-0.05797149,0.019932272,-0.029458228,0.01456927,-0.038629223,0.041557327,-0.04743999,0.19023977,-0.083915904 +2.4.1.130,Four of the nine mannosyl residues in the main membrane lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 are produced by the action of this enzyme.,384,0.99999994,-0.03234168,-0.09715006,-0.10817764,-0.0970476,0.020872105,0.010202378,0.02065315,0.002679091,0.046615016,0.07282091,0.028576698,-0.059175786,-0.06371575,-0.014909575,-0.0202645,-0.064994164,-0.053482376,0.020593174,-0.027675655,-0.061201856,0.09997891,0.034686957,0.032773226,-0.028792152,0.0032281158,-0.054032583,0.022875188,-0.060373973,0.023442904,-0.05105631,-0.02025483,-0.10071228,0.025793293,-0.03409393,0.05367638,0.02874326,-0.02544467,-0.014562832,0.004944409,-0.0075319894,-0.004256108,-0.05743114,-0.017473146,0.006089185,-0.026299417,0.03491971,-0.017474864,0.033019245,0.047223035,0.06572601,-0.025506187,-0.046677794,-0.08260586,0.01515677,0.050715383,0.022435972,-0.080344096,-0.036708336,0.034142192,0.08058475,0.024686554,0.024951894,0.014283886,-0.015220781,0.029275766,-0.0421643,0.09732661,-0.08354379,0.011252001,0.02208588,0.03616849,-0.011624936,-0.039321736,-0.101668894,0.03858097,0.05554963,-0.040128764,-0.03433078,0.0010868751,0.008860953,0.103029795,0.0075742058,0.08317847,0.10474048,-0.058481056,-0.032856293,-0.02765189,-0.009172363,0.06319983,0.04447587,0.00447889,-0.004045016,0.046573628,0.015541345,-0.04925901,-0.0061547034,0.043609817,0.02624112,0.049689896,0.003173784,0.007857943,-0.00419649,0.044953335,-0.060838908,-0.0111441,0.06165745,0.016571911,0.047380406,-0.05329372,0.016767098,0.012031629,0.044732388,-0.021959538,-0.058641218,-0.07454487,0.03726068,0.033891104,-0.09548031,-0.03285358,0.03280296,0.016347427,0.011863099,0.05328667,-0.002013407,-0.069181465,0.01664586,0.016750641,3.1568677e-34,0.025972858,0.0043251794,0.05523498,0.009621552,-0.0067185787,0.0013475649,-0.041105974,-0.023401935,-0.07679126,-0.021117356,-0.05524558,-0.09785694,-0.029676223,0.12208263,-0.06828225,0.058864657,0.0024001317,-0.009868637,0.012692905,-0.0059360256,-0.02619375,0.07790329,0.045823608,-0.030420825,0.12718785,0.024940223,-0.07578437,0.024014393,0.065923035,-0.02405501,0.08660661,-0.05850262,-0.07951888,-0.0010078943,0.07843837,0.048430596,-0.055379394,-0.018018065,0.02948764,0.04117445,0.01362134,-0.00026543628,-0.006089778,-0.045418393,0.034791734,0.010220073,-0.0332633,0.04118342,-0.00431224,0.003319724,0.072212465,0.019574136,-0.008540308,0.10301493,-0.0014458895,-0.031748407,-0.027668905,-0.030563153,0.015498588,0.05487976,0.03660139,0.03028,-0.05584512,-0.013495504,0.043687463,-0.0050352924,-0.10602449,0.028964061,0.0061037354,-0.025641864,0.01353487,-0.11727015,0.07147858,0.03837843,0.069383495,0.0020370758,-0.0417302,0.023045143,-0.04184157,-0.025501352,0.08400397,0.062325973,0.03576216,0.020897502,-0.1436934,0.02564684,-0.0135843875,-0.086400844,-0.06646817,0.042693146,-0.023227567,-0.036069512,-0.068473846,0.05813821,-0.061058253,-3.2498782e-33,0.1006951,-0.069196165,0.107922025,-0.08217405,-0.047728475,0.007748432,0.072304495,-0.07864665,0.020665336,0.009424955,0.08247345,-0.025515214,0.041402705,0.006447923,0.004224762,-0.045461632,-0.056610897,0.055809148,-0.011897861,0.024562137,0.011661616,0.039473504,0.044034675,-0.015034773,0.015636833,-0.026887424,0.021834604,0.03131298,0.0146983005,0.0800822,-0.08350264,-0.02593631,-0.04435987,0.033839677,-0.016976295,-0.022354364,-0.04244822,0.015442374,-0.015901553,0.006856199,-0.043784577,0.03545728,0.024933314,-0.101024084,0.03955587,0.07770168,-0.017799119,0.033003375,-0.1329164,-0.058976837,0.018185576,-0.0067052026,-0.04047967,0.022746528,0.055971,0.13014413,0.06515865,-0.022574408,0.09962519,-0.049425125,-0.016048254,0.011503776,0.040794015,-0.049100712,0.0651273,0.053217158,0.02589142,-0.02328272,0.05681486,-0.031682316,-0.05280492,-0.010135399,-0.013869199,-0.008894419,-0.030847717,0.0010698698,-0.12520552,-0.047417082,-0.022182385,-0.06160916,0.045305245,-0.04344884,0.07059346,0.009436374,0.03764575,-0.036564525,0.12600577,0.11027666,0.034948606,0.05985949,-0.004324556,0.029868353,-0.0555592,0.07691165,0.1045924,-2.8385319e-08,0.015010406,-0.008403807,-0.005285895,-0.103258006,-0.077461295,-0.020264233,0.030007714,-0.00026975136,-0.0014920849,0.02776795,0.029314531,0.08087352,-0.024791725,0.009164335,-0.02272928,0.0002975273,-0.08617781,-0.019337125,-0.008421296,-0.06690423,-0.11573266,0.061844736,-0.06920373,-0.018003805,-0.014415789,-0.042656206,-0.010142652,0.080280766,-0.046172116,-0.010162055,0.0696881,0.027342651,-0.009059916,-0.11111481,0.0049010133,-0.031190343,-0.044499397,-0.025793755,0.02190622,-0.022277694,0.027005225,-0.0035139758,0.004484686,-0.015533674,-0.009877663,0.030674698,-0.0625571,0.09128377,-0.041357223,0.12606156,-0.0046457583,0.036191862,-0.063205466,-0.027624762,-0.04654328,-0.11046186,-0.062329862,-0.0023029884,-0.042050052,-0.07165213,0.0056311293,-0.035911437,0.084692866,-0.055293094 +2.4.1.131,"The biosynthesis of asparagine-linked glycoproteins (N-linked protein glycosylation) utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. ALG11 mannosyltransferase from Saccharomyces cerevisiae carries out two sequential steps in the formation of the lipid-linked core oligosaccharide, adding two mannose residues in alpha(1->2) linkages to the nascent oligosaccharide.",384,1.0,-0.024901988,-0.023829851,-0.105494015,-0.00075169926,-0.016050944,0.018458698,-0.08722431,0.0359081,0.06569893,-0.037441626,0.055335615,0.018741773,-0.08906467,-0.05089732,-0.09247321,-0.040100478,0.007867339,0.029028999,-0.056073338,-0.03584404,0.106065325,0.029715667,0.056858387,-0.04333219,0.09575698,-0.11571904,-0.053847406,-0.11043554,0.04107311,-0.08326514,-0.02237522,-0.07417733,-0.033930384,-0.032828346,0.08343348,0.05254122,0.1004789,-0.0043338514,0.06348727,-0.051967494,0.042247698,-0.07726351,-0.013151191,0.0076249274,-0.07195108,-0.006779102,-0.016807938,0.09350657,0.047746193,0.060025945,-0.0678218,-0.020809786,-0.023008633,-0.020172713,0.02664708,0.1193406,-0.04449562,0.00055191515,0.030334724,0.09061249,-0.0428133,-0.004285664,0.051855046,0.020033814,-0.02635638,-0.1188231,0.07445058,-0.010892969,-0.022247924,0.024618011,-0.023242518,-0.03139666,0.03394845,-0.027479332,0.06671062,0.07772406,-0.00917592,-0.001111423,-0.0060931426,-0.026138471,0.09518062,0.017159814,0.07387041,0.043687616,-0.050120793,-0.079748906,0.0012351259,0.043707028,0.03547901,0.047867797,-0.040603366,-0.022065813,0.06000728,-0.0099999765,0.0011753658,0.015886845,0.068167426,0.017440822,0.017828941,-0.037272025,-0.018198544,0.001839425,0.08701398,-0.051748063,-0.014604621,0.024747498,-0.011328142,0.019870901,-0.003193825,0.0029884994,0.071950026,0.025109215,0.050041188,-0.052909303,-0.103982545,-0.035938907,-0.04021255,-0.07666862,-0.02749112,-0.0716106,0.006772097,0.024749756,0.011406334,0.07519966,-0.03313328,0.026057811,0.012221174,5.4610716e-33,0.096581325,0.03432141,0.028627332,0.018531848,-0.0074785883,-0.029263357,-0.029331176,-0.05008172,-0.114726,0.011298164,-0.033977058,-0.11184857,-0.036276363,0.121965066,-0.008986522,0.016426418,0.039141938,0.012653477,0.035408303,-0.035350032,-0.038514692,0.04298445,-0.022157945,-0.023572074,0.11346753,0.061657123,-0.048645068,0.017354611,0.017798234,-0.024494285,0.07669798,-0.054760877,-0.08240224,0.00097381073,0.06766,0.028851498,-0.004212353,-0.049253345,0.012533839,0.014319319,-0.027724266,0.06520214,-0.032709416,-0.07365532,0.007740477,0.016218903,-0.027234368,-0.02511368,0.005786892,0.057599086,-0.018633122,-0.038724866,0.078549236,0.07073279,-0.065201834,0.013717204,-0.06377656,-0.033060797,0.008192138,0.104372665,-0.041729227,0.002588253,-0.029440636,-0.029134525,0.014773657,0.024424385,-0.037023794,0.018376712,0.0071816617,0.0151081085,-0.061439645,-0.04111735,0.0445427,0.025354141,-0.012997763,-0.02760894,-0.053662725,0.02692483,-0.013105984,0.0052497424,0.09662667,0.07809956,-0.0129435,-0.022972463,-0.04807479,0.025857246,-0.09426987,-0.07900211,-0.009067291,0.008696173,-0.037765384,-0.039709967,-0.030866152,0.062378928,-0.05734311,-7.6489564e-33,0.103870094,-0.075952485,0.11404482,-0.035328005,-0.0965035,0.024998296,0.043184306,-0.023657864,0.030223632,0.010031308,0.007503519,-0.011958539,0.04805435,-0.06113492,-0.022862216,-0.02735215,-0.045558814,0.10226886,-0.0104235485,-0.009236559,0.012997946,0.06171404,0.0046507255,0.025619708,0.039980136,-0.02680182,-0.021364292,0.06043871,-0.033948407,0.057932917,0.024115907,0.017150886,-0.084046125,-0.070427984,-0.046919964,0.019794347,-0.0862794,0.03361563,-0.021222657,-0.014468196,-0.029978938,0.07143525,0.028756743,-0.081967026,0.047866337,0.07984107,-0.050064728,0.023485811,-0.042270217,-0.036228422,-0.0053683985,0.009518581,-0.0019901278,0.057865445,0.051655453,0.04908705,0.0841214,0.011636902,0.04092233,-0.07383572,-0.0526638,-0.03332413,0.06573437,-0.01335861,0.03485596,0.046303887,-0.016058432,-0.066659525,0.011629234,0.024423892,-0.02229775,0.016718179,-0.00089585915,0.03328009,0.026249863,0.0036951194,-0.14217904,-0.06325022,-0.04098053,0.006182896,-0.0042464333,-0.03881389,0.04058778,-0.013531555,0.08488894,-0.003974176,0.11427144,0.11449893,0.007663663,0.12137858,-0.028088897,-0.035248123,-0.048210435,0.076975144,0.009935952,-4.1190205e-08,0.05410439,0.025912767,0.01370277,-0.107964166,-0.051414777,0.06001104,0.02044579,0.03347493,-0.03470721,0.010835483,-0.052689932,0.051092777,-0.019094542,0.005364877,-0.06115626,0.041053474,-0.07289016,0.0066313283,-0.004576574,0.017492687,-0.071894445,0.028813327,-0.041765563,0.10142522,0.047730185,-0.032702107,0.033293504,0.07092247,-0.0052247876,-0.045013085,0.028957028,0.057899855,-0.039055318,-0.051989842,-0.036265068,-0.01601155,-0.040204894,-0.008525036,0.01569569,0.029937925,-0.03125956,-0.009202403,0.034494255,-0.0005961809,-0.038926553,0.04566006,-0.015967026,0.026394442,-0.05916241,0.07544435,0.01584313,-0.013102106,-0.06681979,-0.07368939,-0.07119219,-0.07167633,-0.044783946,-0.009662123,0.0007631305,-0.012275936,0.0012466825,-0.07753911,0.118818335,-0.0965156 +2.4.1.132,"The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha1,3-mannosylation of D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol, followed by an alpha1,6-mannosylation (cf. EC 2.4.1.257), to form the first branched pentasaccharide intermediate of the dolichol pathway [1,2]. ",384,1.0,-0.017922197,-0.041692745,-0.06291057,-0.016680593,-0.028863197,-0.030322,-0.05556188,0.041699305,0.084527306,-0.0016586519,0.053059574,0.024135824,-0.080947705,-0.006899241,-0.08472692,-0.020751093,-0.03338018,0.009871625,-0.033504892,0.032109786,0.06693729,0.030881004,0.027422516,-0.061194457,0.08144882,-0.076334774,-0.04372601,-0.06049791,0.041567784,-0.103559166,-0.0437942,-0.05704663,-0.020738462,-0.04611494,0.08560836,0.040313534,0.05625053,0.0033896586,0.019774683,0.005671002,0.04556256,-0.073116876,-0.0035371226,0.013169597,-0.09671882,0.01233994,-0.026320485,0.09512991,0.036385287,0.09834752,-0.05778989,-0.018865654,0.014063066,0.013633265,0.055471588,0.09806358,-0.025067745,0.05737345,0.002345069,0.068538256,-0.04640363,0.0062552467,-0.010059993,0.02041506,-0.046519585,-0.06857298,0.057353873,-0.032339357,0.007728336,0.009163302,-0.038732737,-0.061763566,0.05600965,-0.016259264,0.053100146,0.09961675,0.013378552,0.0095080845,0.014775887,-0.062104557,0.10683459,-0.009602048,0.0562299,0.047193356,-0.055490773,-0.032252096,-0.02178532,0.03286947,0.085313134,0.0652938,-0.025997534,-0.035308603,0.016205529,-0.025230853,-0.034731764,0.05715548,0.04964615,0.05166001,-0.018956274,0.00493666,0.011050042,0.05506674,0.039438084,-0.07725362,0.0002902127,0.0035115315,-0.035182804,-0.002188869,-0.0035296304,-0.0286952,0.07611569,0.041043427,0.06269189,-0.036326848,-0.09566187,-0.056531876,-0.007830728,-0.054617807,-0.04310146,-0.066878416,0.007191761,0.04692505,-0.0011524407,0.0839914,-0.009345228,0.016492408,-0.004908287,1.9994661e-33,0.047622494,0.07070528,0.039255857,0.039491314,-0.009141652,-0.04910065,-0.034182962,-0.047962964,-0.12446714,-0.031858213,-0.016311983,-0.11239322,-0.050552018,0.10989925,-0.0005035119,0.017124135,0.05017375,-0.0040161693,0.059704922,-0.027812228,0.032163948,0.051872063,-0.03188304,-0.035217896,0.12419962,0.074224554,-0.0075865677,0.04273208,0.012327357,-0.010314702,0.020029645,-0.06471127,-0.07962913,0.008580639,0.0324566,0.022732269,-0.033462208,-0.066476874,0.015532809,0.04693929,-0.008303673,0.035022773,-0.075475186,-0.06169966,0.041254118,-0.012545395,-0.00081883307,-0.01065346,0.0075364443,0.07036582,-0.0119961,-0.04614629,0.07317366,0.08231746,-0.10642143,3.623312e-05,-0.0791967,-0.04391441,0.024016317,0.102838516,-0.039248828,0.041029148,-0.03077781,-0.018131647,0.019435663,-0.0090953,-0.05465088,-0.02216589,-0.035994135,0.0033080662,-0.051296894,-0.05999176,0.07271119,0.014238977,-0.017868074,-0.038661864,-0.024582079,0.036475435,-0.017290013,-0.003764942,0.055288292,0.021764807,-0.013183078,-0.003733648,-0.06378258,-0.006952535,0.00035015642,-0.06847907,-0.060274262,-0.017371044,-0.03211276,-0.024629548,-0.050540682,0.043323282,-0.013459812,-4.4497273e-33,0.10594947,-0.0809979,0.13177584,-0.06264561,-0.0819233,0.022959944,0.05883704,-0.049248867,0.010770828,-0.025854003,-0.008224202,0.010539317,0.033368796,-0.08172891,-0.057318646,-0.084589526,-0.019110395,0.10221855,-0.011506263,-0.008688143,0.024043716,0.09673779,-0.0013197123,0.08303463,0.0040295743,-0.030909818,0.058299605,0.07095911,-0.0530951,0.10297043,0.016093217,0.070349954,-0.020454025,-0.06861111,-0.042990398,0.041039843,-0.09947953,0.04579376,-0.014812148,0.035540998,-0.045527883,0.060013868,0.030957043,-0.10816374,0.060986884,0.12444039,-0.048953876,0.010351809,-0.025259728,-0.070054755,0.019131156,0.022131614,-0.018616041,0.061605256,0.06785602,-0.0003002025,0.029638013,-0.008153156,0.056583844,-0.042072207,-0.06960327,-0.023692776,0.048567362,0.0022313527,0.038032528,0.042347148,0.008257287,-0.034888733,0.007761451,0.010722264,-0.014427227,0.025601314,0.023968391,0.039305463,0.039214253,0.0026024159,-0.11002651,-0.039873686,-0.0056554666,-0.036295447,-0.028758308,-0.060571596,0.023209423,0.043182794,0.061401732,-0.031967394,0.09680396,0.118775256,-0.038732696,0.09966796,-0.05729614,0.015160351,-0.062818155,0.08109195,0.072066694,-4.7401674e-08,0.060228113,0.0299219,0.017390778,-0.086715534,-0.038952112,0.053191766,0.0039561186,0.047596406,0.007017067,0.021610258,-0.06385474,0.031081796,0.036903806,-0.0031630653,-0.025459854,0.068184726,-0.0929761,-0.0052409954,-0.026594408,0.03440367,-0.032901846,-0.0012284385,-0.04943221,0.04532865,0.06205277,-0.061936837,0.026640337,0.057552423,-0.021691494,-0.024439216,0.025633616,0.028010685,-0.06262618,-0.045872785,-0.020581849,-0.012798845,-0.05919202,-0.035016302,0.043863557,0.072224185,-0.060254503,-0.014241645,0.03719313,0.01970575,-0.0693907,0.021888468,-0.005550249,0.039733913,-0.030403687,0.04426647,0.054987784,0.010234257,-0.071686566,-0.10753142,-0.11228041,-0.044029538,-0.071258955,-0.006277371,-0.01431908,-0.04682097,0.021311004,-0.059197247,0.0906516,-0.07213436 +2.4.1.133,"Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.",384,0.99999994,-0.02701316,-0.04480365,-0.061976578,0.015612964,0.0040575555,-0.031177357,-0.01738625,0.04625368,-0.04144503,0.014352811,0.055114195,0.11119495,0.10023005,0.00751167,-0.10352949,0.0050959056,-0.0699281,-0.023553105,-0.005068849,0.014449506,0.12872903,-0.005271978,-0.025625791,-0.079938725,-0.009816401,-0.0456303,0.03363056,-0.0035724316,-0.0028946784,-0.03974219,-0.07552325,-0.035218894,-0.015697202,-0.06793245,0.07353914,0.079482906,0.037368003,0.025553375,0.02108833,-0.011731607,0.028438384,0.025465248,0.07752653,-0.054359872,0.02012975,-0.11451268,-0.0011184252,-0.021516174,-0.01537145,0.11347191,-0.02468978,0.0026782523,-0.0096920505,0.015370425,0.06469479,0.0040503107,-0.12282084,-0.0058502057,0.036953643,-0.03106213,-0.009504019,-0.008875396,-0.03635779,-0.04825635,0.019508213,-0.068394005,0.074545555,-0.01104176,-0.029256899,0.05438188,-0.03080746,0.012868268,0.019019023,0.041940514,0.042137966,0.05796084,-0.020314684,0.017553449,-0.00251284,-0.050633553,0.017905073,0.02687905,0.08667287,0.10149577,-0.036871895,0.040579587,0.05525814,0.04145578,0.010970541,0.031918857,0.028086046,-0.020252105,0.009764504,-0.030976376,0.010973386,-0.011967277,0.005724923,0.027165262,0.0036641608,-0.030597305,-0.009107255,-0.026530584,-0.015091053,-0.09504745,0.019849371,0.015858069,-0.04644839,0.13933791,0.08205234,0.05525083,0.040478893,0.04578846,-0.006474021,-0.03618835,-0.05836541,0.06874704,0.013057062,-0.06632009,-0.04553031,-0.023424879,0.042554174,0.0709355,-0.023300277,0.009662325,-0.028539017,0.004123296,0.0054884893,2.410518e-33,0.10029582,0.037316572,0.04317181,-0.026953693,0.004910623,0.0005710217,-0.074715674,-0.0978427,0.0003242302,-0.025151825,-0.1110007,-0.040167555,-0.022708016,0.05130417,-0.046022642,0.05184723,0.043064177,-0.064378,0.036938004,-0.009622049,-0.021474337,0.093751386,-0.038387414,-0.050125964,0.059995,0.053786885,0.0259134,0.008235902,0.05483471,-0.018993113,0.040249117,-0.0888695,-0.017003657,0.008569216,0.110362634,-0.002673178,-0.020785106,-0.036002122,0.04543635,0.0244614,0.06717794,-0.009896467,-0.030744776,-0.0035176023,0.042547572,-0.039815508,0.032777328,0.04844296,-0.033994414,0.047147494,0.017525945,0.05601268,0.07140941,0.0007463404,-0.09313625,0.0075951847,-0.004152297,-0.028999683,0.014288058,0.094658576,0.02348119,-0.010258735,0.056792848,0.006645725,0.03910748,-0.020284412,-0.06274002,0.007332912,-0.040047385,-0.0026730811,-0.039262757,-0.13312435,0.0970722,0.063252896,-0.012098864,-0.010266614,-0.032457642,0.04257088,-0.014873938,-0.0009379462,-0.06405625,-0.0013591935,-0.09436554,-0.03656857,-0.04309681,0.06675064,-0.06331648,-0.14138193,0.023590688,0.07036302,-0.032188438,0.002297942,-0.0656363,0.04010972,-0.069731675,-5.7628996e-33,0.007830865,-0.019433884,0.09317528,-0.021725891,-0.1133789,0.0015535167,-0.0114840185,-0.025476206,0.004200146,0.023725066,0.03124867,0.031373918,0.022680048,-0.048497494,-0.015568385,0.06021889,-0.005248886,0.11238617,0.019719154,-0.0052408217,0.0063720755,0.0864784,-0.023765959,0.06098038,0.042184383,0.039082646,0.030713387,0.0398642,0.011085688,0.08959791,-0.006556366,-0.035222087,-0.07421869,-0.114447564,-0.069400996,0.03486847,-0.051954012,-0.04707022,0.014189746,-0.017185949,0.0136235375,-0.044627983,0.04650341,0.06536457,0.03737508,0.010403313,-0.054383814,0.052552346,0.014068275,-0.029517982,-0.023505412,0.06318007,-0.011872532,-0.0010835956,0.023591185,0.032859202,-0.002858393,0.08132508,0.070622355,0.01306171,-0.06486003,-0.031122876,-0.02081086,-0.046940796,0.04978853,0.07207661,0.023478964,-0.07008593,0.027387496,-0.016950507,-0.034613,0.00659937,0.06643836,0.01762986,0.024527054,0.01902862,-0.09961984,-0.06880983,-0.03754609,-0.028463839,0.00031065798,0.013228632,0.036979627,-0.07566851,0.003835864,-0.027498463,0.053848073,0.074231654,-0.027335268,-0.008619441,0.03403293,-0.07212514,-0.063015185,-0.0027965067,-0.077845804,-3.3198535e-08,0.035863794,-0.06680028,0.005234557,-0.11565259,-0.095959656,0.023195,-0.036590237,0.031471513,0.0049375542,0.00020815294,0.0114667,0.03181025,-0.045224734,-0.07227541,-0.033143476,0.052627232,-0.0024574094,0.030791696,-0.07246593,-0.01672423,-0.111911595,-0.03735409,-0.106649645,0.15745977,0.022566909,-0.0412661,0.03483445,0.010776017,-0.043639395,-0.027387166,0.010154454,-0.0044494784,-0.0626365,-0.055903994,-0.06781031,0.035190105,-0.018782262,-0.014334778,0.07897292,-0.033765357,-0.024635432,0.0067658904,-0.015956396,0.04208055,-0.070598364,-0.04372397,-0.018939342,0.056108598,-0.05568854,0.038378943,-0.03385649,-0.07959897,-6.8192994e-06,-0.1503567,-0.056579053,-0.0345166,0.03488063,-0.026961105,0.01255516,0.058981147,-0.06632041,0.010215761,0.15336195,-0.0775396 +2.4.1.134,"Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.",384,0.99999994,-0.02701316,-0.04480365,-0.061976578,0.015612964,0.0040575555,-0.031177357,-0.01738625,0.04625368,-0.04144503,0.014352811,0.055114195,0.11119495,0.10023005,0.00751167,-0.10352949,0.0050959056,-0.0699281,-0.023553105,-0.005068849,0.014449506,0.12872903,-0.005271978,-0.025625791,-0.079938725,-0.009816401,-0.0456303,0.03363056,-0.0035724316,-0.0028946784,-0.03974219,-0.07552325,-0.035218894,-0.015697202,-0.06793245,0.07353914,0.079482906,0.037368003,0.025553375,0.02108833,-0.011731607,0.028438384,0.025465248,0.07752653,-0.054359872,0.02012975,-0.11451268,-0.0011184252,-0.021516174,-0.01537145,0.11347191,-0.02468978,0.0026782523,-0.0096920505,0.015370425,0.06469479,0.0040503107,-0.12282084,-0.0058502057,0.036953643,-0.03106213,-0.009504019,-0.008875396,-0.03635779,-0.04825635,0.019508213,-0.068394005,0.074545555,-0.01104176,-0.029256899,0.05438188,-0.03080746,0.012868268,0.019019023,0.041940514,0.042137966,0.05796084,-0.020314684,0.017553449,-0.00251284,-0.050633553,0.017905073,0.02687905,0.08667287,0.10149577,-0.036871895,0.040579587,0.05525814,0.04145578,0.010970541,0.031918857,0.028086046,-0.020252105,0.009764504,-0.030976376,0.010973386,-0.011967277,0.005724923,0.027165262,0.0036641608,-0.030597305,-0.009107255,-0.026530584,-0.015091053,-0.09504745,0.019849371,0.015858069,-0.04644839,0.13933791,0.08205234,0.05525083,0.040478893,0.04578846,-0.006474021,-0.03618835,-0.05836541,0.06874704,0.013057062,-0.06632009,-0.04553031,-0.023424879,0.042554174,0.0709355,-0.023300277,0.009662325,-0.028539017,0.004123296,0.0054884893,2.410518e-33,0.10029582,0.037316572,0.04317181,-0.026953693,0.004910623,0.0005710217,-0.074715674,-0.0978427,0.0003242302,-0.025151825,-0.1110007,-0.040167555,-0.022708016,0.05130417,-0.046022642,0.05184723,0.043064177,-0.064378,0.036938004,-0.009622049,-0.021474337,0.093751386,-0.038387414,-0.050125964,0.059995,0.053786885,0.0259134,0.008235902,0.05483471,-0.018993113,0.040249117,-0.0888695,-0.017003657,0.008569216,0.110362634,-0.002673178,-0.020785106,-0.036002122,0.04543635,0.0244614,0.06717794,-0.009896467,-0.030744776,-0.0035176023,0.042547572,-0.039815508,0.032777328,0.04844296,-0.033994414,0.047147494,0.017525945,0.05601268,0.07140941,0.0007463404,-0.09313625,0.0075951847,-0.004152297,-0.028999683,0.014288058,0.094658576,0.02348119,-0.010258735,0.056792848,0.006645725,0.03910748,-0.020284412,-0.06274002,0.007332912,-0.040047385,-0.0026730811,-0.039262757,-0.13312435,0.0970722,0.063252896,-0.012098864,-0.010266614,-0.032457642,0.04257088,-0.014873938,-0.0009379462,-0.06405625,-0.0013591935,-0.09436554,-0.03656857,-0.04309681,0.06675064,-0.06331648,-0.14138193,0.023590688,0.07036302,-0.032188438,0.002297942,-0.0656363,0.04010972,-0.069731675,-5.7628996e-33,0.007830865,-0.019433884,0.09317528,-0.021725891,-0.1133789,0.0015535167,-0.0114840185,-0.025476206,0.004200146,0.023725066,0.03124867,0.031373918,0.022680048,-0.048497494,-0.015568385,0.06021889,-0.005248886,0.11238617,0.019719154,-0.0052408217,0.0063720755,0.0864784,-0.023765959,0.06098038,0.042184383,0.039082646,0.030713387,0.0398642,0.011085688,0.08959791,-0.006556366,-0.035222087,-0.07421869,-0.114447564,-0.069400996,0.03486847,-0.051954012,-0.04707022,0.014189746,-0.017185949,0.0136235375,-0.044627983,0.04650341,0.06536457,0.03737508,0.010403313,-0.054383814,0.052552346,0.014068275,-0.029517982,-0.023505412,0.06318007,-0.011872532,-0.0010835956,0.023591185,0.032859202,-0.002858393,0.08132508,0.070622355,0.01306171,-0.06486003,-0.031122876,-0.02081086,-0.046940796,0.04978853,0.07207661,0.023478964,-0.07008593,0.027387496,-0.016950507,-0.034613,0.00659937,0.06643836,0.01762986,0.024527054,0.01902862,-0.09961984,-0.06880983,-0.03754609,-0.028463839,0.00031065798,0.013228632,0.036979627,-0.07566851,0.003835864,-0.027498463,0.053848073,0.074231654,-0.027335268,-0.008619441,0.03403293,-0.07212514,-0.063015185,-0.0027965067,-0.077845804,-3.3198535e-08,0.035863794,-0.06680028,0.005234557,-0.11565259,-0.095959656,0.023195,-0.036590237,0.031471513,0.0049375542,0.00020815294,0.0114667,0.03181025,-0.045224734,-0.07227541,-0.033143476,0.052627232,-0.0024574094,0.030791696,-0.07246593,-0.01672423,-0.111911595,-0.03735409,-0.106649645,0.15745977,0.022566909,-0.0412661,0.03483445,0.010776017,-0.043639395,-0.027387166,0.010154454,-0.0044494784,-0.0626365,-0.055903994,-0.06781031,0.035190105,-0.018782262,-0.014334778,0.07897292,-0.033765357,-0.024635432,0.0067658904,-0.015956396,0.04208055,-0.070598364,-0.04372397,-0.018939342,0.056108598,-0.05568854,0.038378943,-0.03385649,-0.07959897,-6.8192994e-06,-0.1503567,-0.056579053,-0.0345166,0.03488063,-0.026961105,0.01255516,0.058981147,-0.06632041,0.010215761,0.15336195,-0.0775396 +2.4.1.135,"Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.",384,0.99999994,-0.02701316,-0.04480365,-0.061976578,0.015612964,0.0040575555,-0.031177357,-0.01738625,0.04625368,-0.04144503,0.014352811,0.055114195,0.11119495,0.10023005,0.00751167,-0.10352949,0.0050959056,-0.0699281,-0.023553105,-0.005068849,0.014449506,0.12872903,-0.005271978,-0.025625791,-0.079938725,-0.009816401,-0.0456303,0.03363056,-0.0035724316,-0.0028946784,-0.03974219,-0.07552325,-0.035218894,-0.015697202,-0.06793245,0.07353914,0.079482906,0.037368003,0.025553375,0.02108833,-0.011731607,0.028438384,0.025465248,0.07752653,-0.054359872,0.02012975,-0.11451268,-0.0011184252,-0.021516174,-0.01537145,0.11347191,-0.02468978,0.0026782523,-0.0096920505,0.015370425,0.06469479,0.0040503107,-0.12282084,-0.0058502057,0.036953643,-0.03106213,-0.009504019,-0.008875396,-0.03635779,-0.04825635,0.019508213,-0.068394005,0.074545555,-0.01104176,-0.029256899,0.05438188,-0.03080746,0.012868268,0.019019023,0.041940514,0.042137966,0.05796084,-0.020314684,0.017553449,-0.00251284,-0.050633553,0.017905073,0.02687905,0.08667287,0.10149577,-0.036871895,0.040579587,0.05525814,0.04145578,0.010970541,0.031918857,0.028086046,-0.020252105,0.009764504,-0.030976376,0.010973386,-0.011967277,0.005724923,0.027165262,0.0036641608,-0.030597305,-0.009107255,-0.026530584,-0.015091053,-0.09504745,0.019849371,0.015858069,-0.04644839,0.13933791,0.08205234,0.05525083,0.040478893,0.04578846,-0.006474021,-0.03618835,-0.05836541,0.06874704,0.013057062,-0.06632009,-0.04553031,-0.023424879,0.042554174,0.0709355,-0.023300277,0.009662325,-0.028539017,0.004123296,0.0054884893,2.410518e-33,0.10029582,0.037316572,0.04317181,-0.026953693,0.004910623,0.0005710217,-0.074715674,-0.0978427,0.0003242302,-0.025151825,-0.1110007,-0.040167555,-0.022708016,0.05130417,-0.046022642,0.05184723,0.043064177,-0.064378,0.036938004,-0.009622049,-0.021474337,0.093751386,-0.038387414,-0.050125964,0.059995,0.053786885,0.0259134,0.008235902,0.05483471,-0.018993113,0.040249117,-0.0888695,-0.017003657,0.008569216,0.110362634,-0.002673178,-0.020785106,-0.036002122,0.04543635,0.0244614,0.06717794,-0.009896467,-0.030744776,-0.0035176023,0.042547572,-0.039815508,0.032777328,0.04844296,-0.033994414,0.047147494,0.017525945,0.05601268,0.07140941,0.0007463404,-0.09313625,0.0075951847,-0.004152297,-0.028999683,0.014288058,0.094658576,0.02348119,-0.010258735,0.056792848,0.006645725,0.03910748,-0.020284412,-0.06274002,0.007332912,-0.040047385,-0.0026730811,-0.039262757,-0.13312435,0.0970722,0.063252896,-0.012098864,-0.010266614,-0.032457642,0.04257088,-0.014873938,-0.0009379462,-0.06405625,-0.0013591935,-0.09436554,-0.03656857,-0.04309681,0.06675064,-0.06331648,-0.14138193,0.023590688,0.07036302,-0.032188438,0.002297942,-0.0656363,0.04010972,-0.069731675,-5.7628996e-33,0.007830865,-0.019433884,0.09317528,-0.021725891,-0.1133789,0.0015535167,-0.0114840185,-0.025476206,0.004200146,0.023725066,0.03124867,0.031373918,0.022680048,-0.048497494,-0.015568385,0.06021889,-0.005248886,0.11238617,0.019719154,-0.0052408217,0.0063720755,0.0864784,-0.023765959,0.06098038,0.042184383,0.039082646,0.030713387,0.0398642,0.011085688,0.08959791,-0.006556366,-0.035222087,-0.07421869,-0.114447564,-0.069400996,0.03486847,-0.051954012,-0.04707022,0.014189746,-0.017185949,0.0136235375,-0.044627983,0.04650341,0.06536457,0.03737508,0.010403313,-0.054383814,0.052552346,0.014068275,-0.029517982,-0.023505412,0.06318007,-0.011872532,-0.0010835956,0.023591185,0.032859202,-0.002858393,0.08132508,0.070622355,0.01306171,-0.06486003,-0.031122876,-0.02081086,-0.046940796,0.04978853,0.07207661,0.023478964,-0.07008593,0.027387496,-0.016950507,-0.034613,0.00659937,0.06643836,0.01762986,0.024527054,0.01902862,-0.09961984,-0.06880983,-0.03754609,-0.028463839,0.00031065798,0.013228632,0.036979627,-0.07566851,0.003835864,-0.027498463,0.053848073,0.074231654,-0.027335268,-0.008619441,0.03403293,-0.07212514,-0.063015185,-0.0027965067,-0.077845804,-3.3198535e-08,0.035863794,-0.06680028,0.005234557,-0.11565259,-0.095959656,0.023195,-0.036590237,0.031471513,0.0049375542,0.00020815294,0.0114667,0.03181025,-0.045224734,-0.07227541,-0.033143476,0.052627232,-0.0024574094,0.030791696,-0.07246593,-0.01672423,-0.111911595,-0.03735409,-0.106649645,0.15745977,0.022566909,-0.0412661,0.03483445,0.010776017,-0.043639395,-0.027387166,0.010154454,-0.0044494784,-0.0626365,-0.055903994,-0.06781031,0.035190105,-0.018782262,-0.014334778,0.07897292,-0.033765357,-0.024635432,0.0067658904,-0.015956396,0.04208055,-0.070598364,-0.04372397,-0.018939342,0.056108598,-0.05568854,0.038378943,-0.03385649,-0.07959897,-6.8192994e-06,-0.1503567,-0.056579053,-0.0345166,0.03488063,-0.026961105,0.01255516,0.058981147,-0.06632041,0.010215761,0.15336195,-0.0775396 +2.4.1.136,"A number of substituted benzoic acids and, more slowly, cinnamic acids, can act as acceptors. Vanillin is the best acceptor investigated.",384,0.99999994,-0.043643776,-0.052689556,-0.08954095,-0.04387155,0.050110124,0.064089365,-0.050178092,-0.005768404,0.06826779,-0.07493914,0.08354605,-0.06821137,-0.078810304,0.070242465,-0.0062957727,-0.023461333,0.0048558684,0.03617664,-0.030387131,0.010569517,-0.12601823,0.009580761,-0.019990155,-0.034855306,-0.052173074,0.051589075,0.012151597,0.029780312,0.054278053,-0.09144642,-0.03844995,2.0553553e-05,0.014501797,0.010621218,-0.06889547,-0.050538965,-0.08017185,-0.028231533,0.07865818,0.009618065,-0.008950337,-0.05787751,0.010639992,-0.034147326,-0.05147828,-0.07251824,0.064712375,-0.023900414,0.0044026016,-0.05415035,0.022616675,0.044759944,0.014536913,0.05943207,-0.09800133,-0.055351183,-0.1069,-0.013835423,-0.034821637,-0.022149572,0.007236578,-0.026860373,-0.021967547,0.008052719,-0.09944191,0.0075887847,0.04479035,-0.08514793,0.026451927,0.007322255,-0.05472804,-0.012234067,0.017209059,-0.02792453,0.053763926,0.11870138,-0.012291345,-0.023927307,0.021926984,-0.03741921,0.010519303,0.0059329616,-0.030740121,0.050677907,0.053876713,-0.018779712,-0.034267135,0.034855984,0.015675934,0.050230697,0.06893005,0.04932034,0.01535025,-0.06261783,-0.0077874013,-0.00962079,0.057453208,-0.0045437785,0.016953606,0.031960182,0.0054277224,0.13192658,-0.060328282,-0.1117671,-0.07833709,0.019963648,0.0075882375,-0.0109428065,-0.008344629,-0.033717964,-0.022339223,-0.09412629,0.033172764,-0.000558446,0.004120255,-0.0141861765,0.038214438,-0.09035774,-0.014440729,-0.033092286,-0.010396833,-0.026909372,0.037756648,-0.0050699394,-0.010124214,0.01622814,-0.02687456,-2.7124603e-34,-0.009174475,0.045505963,-0.011889363,-0.026552025,0.008977906,0.013284148,-0.12096412,0.017398912,-0.015050296,-0.09499814,-0.087857984,0.020329056,-0.003863339,0.027961785,-0.005222157,0.0129227955,0.03198943,0.03509066,0.035737306,-0.095452696,0.042180642,0.09717705,-0.020306863,-0.034356497,0.012034516,0.049724378,0.0021513505,0.057047956,0.0047460883,-0.02403625,0.02035063,0.04741418,-0.038251717,0.07658948,-0.007035094,0.06655694,-0.039872278,0.008497128,0.05587723,-0.0855106,0.046033684,0.0854763,-0.043222558,0.032824676,-0.0055442695,-0.024918877,-0.03368093,0.019611217,-0.0031134565,-0.008943036,0.004860514,0.001675559,-0.086248145,-0.039705295,0.02303274,-0.008624381,0.027406188,0.09408038,-0.015071274,0.010182711,-0.03793522,0.042471692,-0.059465338,0.01764039,-0.028618306,-0.007995725,-0.11737266,-0.05825143,-0.013128488,-0.028954346,0.006638835,0.031131184,0.07216866,0.04976932,0.046526197,-0.04733651,-0.053575087,-0.029011037,0.0660957,0.014792217,-0.03759325,-0.026426535,-0.039897207,0.041270666,-0.07320698,-0.01366973,0.029849278,-0.010594069,0.04810294,-0.040359784,-0.009654069,-0.05033007,0.018798292,-0.021023301,0.079132125,-2.1155972e-33,0.104859605,-0.07228331,0.0794123,0.04368256,0.08232714,0.054547247,-0.03196796,-0.080633685,0.060071334,-0.03897765,0.08466116,0.010200031,0.08401074,0.022882942,0.03747111,-0.01440158,0.03759484,0.009583631,-0.010297584,-0.052234374,-0.052488916,0.05683119,-0.0038090742,0.0023641402,0.03081438,0.066949144,0.010643613,-0.004005689,0.0037608102,0.09392447,-0.03401327,0.059192892,-0.014118437,-0.06985636,0.06306272,0.076462924,-0.015183939,0.031329785,-0.04588341,0.053777777,-0.0048598843,-0.0408007,0.022746641,0.04171931,0.051143408,0.0038407382,0.006896165,-0.0348645,-0.04372066,-0.03668004,0.04609022,0.03737595,-0.026804173,-0.009990255,0.12917091,0.14805819,0.021892972,-0.09481283,0.034322355,-0.04549771,-0.07327089,-0.022852888,0.041881014,-0.03721011,-0.05104989,-0.032092553,-0.03841184,0.09852292,0.087676294,-0.11696139,0.11274329,-0.014280487,0.08847144,0.06118246,0.033986833,-0.06311339,0.022653375,-0.03198988,0.024657944,-0.05684609,-0.11333549,-0.0020301507,-0.0121918265,-0.025545985,-0.02012028,-0.03214784,0.0070853205,-0.0666491,-0.021246422,-0.00663524,0.05432477,0.0353734,0.06789065,0.076121636,0.06709965,-2.7992359e-08,0.021368615,-0.06383704,0.05651982,-0.040503047,0.016803386,0.02304642,0.0003080461,0.003686452,-0.04300549,-0.033094883,0.08895065,0.05100748,0.059326656,0.010833682,-0.008071918,0.070163794,-0.066299215,-0.02487479,-0.043606285,0.04088469,-0.06699354,0.041056093,-0.013829384,-0.11149831,0.0077868425,0.0069906865,-0.07776527,-0.01740063,-0.12825134,-0.014738158,0.044441268,0.0106343655,0.08782224,-0.025288656,0.08534783,0.043676436,0.06766704,-0.06647145,-0.080449305,-0.011852119,0.08183974,-0.09064955,-0.14453934,-3.587736e-05,0.031609807,0.011213102,-0.022188269,0.04253061,-0.077145666,-0.006384037,0.005612119,0.034076694,0.05374988,0.018639345,0.016637808,0.010225272,-0.009771217,0.0207797,0.007702704,-0.025582742,0.004007612,0.06255202,0.117603764,0.022199236 +2.4.1.137,The product is hydrolysed by a phosphatase to floridoside (cf. EC 2.4.1.96 sn-glycerol-3-phosphate 1-galactosyltransferase).,384,1.0,-0.0024799774,-0.061999798,-0.1537101,0.020457167,0.084706776,-0.00015565663,0.007905537,0.089110605,-0.0114934305,-0.03732237,0.032020245,-0.0038638604,-0.0691851,-0.0011656556,-0.0962921,-0.061845995,-0.006791538,0.037365723,0.005272721,0.032907385,0.12780266,0.020637786,-0.002455421,0.0786645,0.041679543,-0.041657537,0.011035042,-0.099010505,-0.033831798,-0.049245868,0.066162586,-0.012751514,0.11452929,-0.07170953,-0.0047748433,0.05549365,0.008283286,-0.038655654,-0.010760766,-0.018912036,0.03247853,-0.0750567,0.061765075,-0.05345806,0.0013686351,-0.012760205,-0.024471553,0.08528511,0.028738178,0.04527119,-0.043762967,-0.038141213,-0.12035333,0.005523551,-0.0062459274,0.04013199,-0.07358304,-0.028474027,-0.031134719,0.033609144,-0.0051831026,0.020868482,0.04996281,0.06935869,0.010889274,-0.018394466,0.0005144538,-0.09688587,-0.026469694,-0.026546158,-0.024463946,-0.023692038,0.022566471,-0.05309832,-0.022205003,0.07179993,0.010759775,0.04156516,0.07774491,0.009109261,0.06839821,-0.048075065,0.0040892274,0.057729818,0.01551912,0.009371174,-0.030926231,0.027397316,0.004518509,0.018844806,-0.00013391627,-0.0032475176,0.04758231,-0.009493415,-0.056260396,0.059709813,0.012994042,-0.002783941,0.045491293,-0.0057225907,-0.045281217,-0.0011255224,0.042064436,-0.04856611,-0.08206462,0.052341584,-0.030402808,0.05517533,0.025858982,0.014978319,-0.016155,0.022555748,0.021040728,-0.0011774893,-0.012433393,0.07289624,-0.021905102,-0.051443778,-0.08204649,0.0031486927,0.03652506,-0.033911712,0.02983068,0.017789517,0.00022319985,0.026129022,0.018411797,2.2500988e-33,0.048466146,0.075082816,0.09164652,-0.037713423,-0.049245384,-0.0265133,-0.037824605,-0.08507064,-0.07720316,-0.010883781,-0.045725103,0.020844065,0.012509449,0.04484811,0.0017174076,0.0026872798,0.03835971,-0.004056539,0.11251332,-0.03432215,0.016860716,0.049444683,-0.056950025,-0.009602733,0.02298685,0.040185243,-0.026986763,0.010628997,0.06156304,0.054672465,0.007995544,-0.0829801,-0.07018621,-0.01511448,0.010826049,-0.016261585,-0.06644573,-0.11190841,0.021323754,0.056079905,0.023355894,-0.018595988,0.017564997,0.01519628,-0.0045185722,0.0012943142,-0.037797026,0.080129854,0.12397242,0.055120222,-0.03665443,-0.036334753,0.029643655,0.030888295,-0.030943727,0.031016901,-0.08124147,-0.034061827,0.006132008,0.030138599,0.0053943424,0.09546897,-0.03672283,0.00956751,-0.02304718,-0.008614241,-0.007566464,-0.027890313,-0.0060671614,-0.043727327,-0.00068267464,-0.048767347,0.09336396,0.0461364,-0.0036163258,-0.05354159,0.09004739,0.013276783,-0.045687333,0.060141005,0.003453963,0.051348787,-0.054192092,-0.0012072216,0.025878724,0.05642788,-0.092498966,-0.043860067,-0.02334467,0.03748994,-0.007073296,-0.08143627,-0.0067853592,0.026708255,-0.05938385,-2.2536543e-33,0.041440524,-0.12423076,0.045756996,-0.025348179,-0.008027861,0.015680457,0.042512044,0.009645952,0.08025782,-0.0075969878,-0.035304036,-0.019786596,0.040511593,-0.16065627,-0.017659675,0.059132807,0.100525774,0.038189553,-0.0039277263,-0.030139197,0.039289244,0.047653712,0.025178425,0.050516862,-0.010739282,0.013008333,0.0048067276,0.042193882,0.0063493885,0.08588313,0.0009972695,-0.013106399,-0.07691717,-0.10445019,-0.056702778,-0.025904452,-0.048363704,-0.0052849613,-0.017831631,-0.05947924,0.0008551905,0.045407098,0.07862911,-0.009290199,0.109347135,0.10716993,-0.0645426,0.011017125,0.037023257,0.00018857625,-0.014331556,0.03544457,-0.06233862,0.11051522,0.04091844,0.02809637,0.046864938,0.09567395,-0.049954575,-0.03535996,0.0049109207,-0.08097868,0.015340494,-0.047225133,0.06755701,0.070673004,-0.005874676,0.015818637,0.0041872226,0.034387536,0.05934044,-0.028889794,0.013631775,0.100267075,0.050710764,0.022389524,-0.13830033,-0.048801325,-0.013219032,-0.017453859,0.11048015,0.028846188,0.040700734,-0.05279177,0.032116886,-0.087223925,0.05588003,0.06729044,0.007613011,0.0075218678,-0.07621001,-0.043977637,-0.07549709,-0.041154016,0.0692545,-3.1712425e-08,0.03266496,-0.08940481,0.05339132,-0.11311224,-0.042745054,0.06642217,0.04432917,0.0057817386,-0.021655845,-0.13610247,-0.03560282,0.060428802,0.033975735,-0.035897553,0.01762203,0.046870552,0.0077797635,0.026492069,-0.03859037,-0.055508662,-0.01298382,0.0008807062,-0.0030186756,-0.0045755636,-0.050520737,0.0191251,0.041758765,0.010413488,-0.020430943,-0.05018086,0.037661776,-0.0007033339,-0.030162904,0.03285465,-0.0627903,-0.02065213,-0.042979334,0.015966464,-0.010992826,0.066755995,-0.077381164,0.010823783,0.037952796,0.057111613,-0.02193315,0.025574,-0.020458313,0.06471859,-0.03354155,0.011437535,0.006871193,-0.06990904,-0.12004178,-0.08494165,-0.08290113,-0.09106794,0.067140676,-0.048817337,-0.025277706,-0.052066058,-0.000116281226,0.012120391,0.15156527,0.022399068 +2.4.1.139,Neither free phosphate nor maltose 1-phosphate is an intermediate in the reaction.,384,1.0,0.0035324988,-0.06434505,-0.012075262,0.008406895,0.0348222,0.016822191,-0.06831373,-0.020844955,0.055937555,0.021192372,0.04851395,0.012210721,-0.073187575,-0.03769644,-0.019636218,-0.023824427,-0.010955239,-0.04929196,0.026351579,0.044465046,0.091995575,0.008256252,0.041590244,-0.014704779,0.11640849,0.058716908,0.046596464,0.009877504,0.049917057,-0.04565748,-0.06481805,-0.05464889,-0.028651807,-0.038380597,0.047454845,0.09894444,0.020421473,0.010973871,-0.032063294,-0.029449683,0.034410935,-0.03090391,-0.04277845,0.029908834,-0.0393038,-0.01576401,-0.062230717,-0.03865649,-0.05446306,-0.03654687,-0.09737366,-0.07943236,-0.064194426,-0.003416602,0.0032014833,0.028269233,0.0150654875,0.06448376,-0.028316429,-0.047859654,-0.015268376,0.03610721,-0.031230092,-0.0045030853,0.06191719,-0.033636723,0.016265605,-0.043685645,-0.049804624,-0.038018968,-0.05057173,-0.07017949,0.036824606,-0.029129157,0.03170981,-0.03111095,0.008706508,-0.00515305,0.007069672,0.07806056,-0.0038942676,-0.08103174,0.0064500505,0.08181036,-0.032887492,-0.056991294,-0.016989017,0.04558604,0.019804515,-0.01778831,-0.05389205,0.015229559,0.039781917,-0.074397705,0.06247668,0.04636634,-0.029208308,-0.019823398,0.042036965,-0.029848626,-0.034415178,0.037288446,0.0065033124,-0.027408784,-0.04532346,0.08031837,-0.06726192,0.052844122,0.0011968896,0.033057313,0.016231056,-0.011181984,0.0823958,0.024588937,-0.10703925,0.0672795,-0.04977763,-0.074404076,-0.0028014,0.024438044,0.023797432,-0.027005773,0.040157665,0.08490609,-0.080229156,-0.0008340125,-0.029182103,-2.3002959e-33,0.0922165,-0.012414103,0.052609324,-0.09456512,-0.060579382,0.046938047,-0.036429677,-0.05268476,-0.029279599,0.006425131,-0.042491496,-0.06229114,0.06442549,-0.048980504,-0.0071964674,0.010047785,0.04651006,-0.01969257,0.09674518,0.012577157,-0.016687866,0.05626438,-0.0810273,-0.016504439,-0.06260767,-0.012234876,-0.04345463,-0.026014455,-0.07323279,-0.033342656,-0.020877713,-0.018763704,-0.05221096,0.018987212,0.055214304,-0.060877007,-0.09642564,-0.012473822,0.011344335,-0.053182133,-0.0056993566,0.011204175,0.07460516,-0.059483185,0.062299777,-0.1329515,-0.04480646,0.04078081,0.00956333,0.10515905,0.042524934,0.00042383108,-0.006527992,0.026573775,-0.008791688,0.018271046,0.009155284,0.0606435,-0.025307568,0.006574373,0.011453998,0.029283257,0.009145701,0.008199716,0.0276583,0.005584062,-0.108651906,-0.0019864962,0.02622913,0.06148639,-0.005839122,0.005553794,0.09936331,0.022092735,-0.020739378,-0.045285884,-0.038467012,0.03806676,0.038488183,0.057924,0.08643492,-0.05234471,0.0023624606,-0.017866453,-0.05995983,0.03202393,-0.086833775,0.01275139,-0.003829102,0.095414616,0.05177676,-0.03281913,-0.11860895,-0.0053774095,0.06239617,-3.4419487e-34,0.12460418,-0.045173228,0.040909294,-0.050897803,-0.06600704,0.041141372,0.09649451,-0.06568723,0.06674504,0.050721537,0.047222633,0.02795256,-0.025831334,-0.048762944,-0.024651485,0.0924662,-0.027401883,0.054389138,0.0018245614,0.017813291,0.027332926,0.14545344,-0.057471227,0.1141217,-0.0024091094,-0.017664883,0.008389384,0.07945656,-0.052667383,0.1088909,0.02320313,-0.039969765,-0.022815298,-0.11169192,-0.011659204,-0.07428424,-0.08684099,-0.050875697,-0.013755087,0.023629885,0.023150142,0.08104377,0.05683879,0.06550949,0.027992163,0.018940497,0.0067416034,-0.013513647,-0.0014771454,-0.025241677,-0.06168915,0.07566823,-0.02773477,-0.016270973,0.044647627,0.050920792,0.01889208,0.0029804686,-0.017911145,-0.069735765,0.02007534,-0.010015776,0.047782376,-0.105957545,0.095271565,0.12113894,-0.028676117,0.09826399,0.063672945,0.014680507,0.03846335,0.008868311,0.08899471,-0.07208263,0.03218034,-0.017435024,-0.102106795,-0.016799994,0.040580697,-0.097299695,0.02282518,0.07842919,-0.05987737,-0.013317717,0.019547815,-0.024012988,-0.028813126,-0.009712764,-0.049186297,-0.008264355,0.004779539,-0.024114028,0.05224611,0.01091109,0.12943223,-1.9102155e-08,0.07062733,-0.0095007215,0.013247552,0.025014399,-0.028206112,0.063297994,0.0015416042,-0.039253928,0.00052955654,0.054538168,-0.038427267,0.052334137,-0.021829085,-0.018223574,0.040113557,0.006801753,-0.021514455,-0.03286616,-0.08568719,-0.072271846,-0.058158893,0.046118997,-0.089261994,0.014586477,-0.012323852,1.0287845e-05,0.029916566,-0.012580753,0.04257124,-0.070792496,0.06819609,-0.0007606249,-0.018280711,-0.056765717,-0.05522029,0.0380813,0.047920607,0.02597919,-0.015726734,-0.06751448,-0.0022643826,0.013559673,-0.03813044,0.018536333,-0.059649996,0.08509881,-0.010036799,-0.025458744,-0.065755635,0.05251657,0.010813154,0.002218559,-0.07420023,-0.015053881,-0.00699815,-0.0030961365,0.066343896,-0.001602791,0.008350744,-0.0039484333,0.09432631,-0.039915122,0.17903124,-0.0585347 +2.4.1.140,"The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme forms both alpha(1->3) and alpha(1->6) linkages in approximately equal amounts by alternating the linkage type. cf. EC 2.4.1.125, sucrose---1,6-alpha-glucan 3(6)-alpha-glucosyltransferase.",384,0.99999994,-0.043194275,-0.08664958,-0.099355936,-0.0063990913,0.05634214,-0.0067291968,-0.005691485,0.023815976,0.06208013,-0.011435053,0.04816951,0.11157851,-0.0123680215,0.010351918,-0.12030487,-0.0058473228,-0.1079374,0.015009463,-0.098418444,-0.028261894,0.14361523,-0.011375008,-0.018111922,0.00029883726,0.09930449,-0.051224437,0.016311055,-0.062979855,0.041407254,-0.049875837,-0.077939436,-0.07021623,-0.034740444,0.021235444,0.0626449,0.064442776,-0.059372015,0.020577682,0.02800038,0.02049523,0.022552537,-0.0140854195,0.0146534145,0.060628142,-0.07447839,-0.02587225,-0.14342618,0.08420808,-0.021639477,0.048205078,0.018687956,-0.038842127,-0.09480849,0.037124276,0.017882077,0.036153145,-0.01421671,-0.015253123,0.022432972,0.09138343,0.036927734,0.009815108,-0.064203866,-0.038855392,-0.0034740902,-0.042642623,0.09064465,-0.029307932,-0.04229625,-0.00053233583,-0.045494158,0.011760293,0.008325979,0.04467021,0.047325917,-0.008089378,-0.02302548,0.05432705,-0.032256424,-0.021419203,0.05949825,-0.021826012,0.079604216,0.09402053,0.010596131,-0.017783076,-0.025596745,0.0054609645,-0.008390343,0.044282403,0.030173087,-0.038811516,-0.0012776722,-0.088187486,0.019739207,0.058827892,-0.020492313,0.010072404,0.10915268,-0.064302154,0.0007228832,-0.007675285,0.03586221,-0.018941682,-0.046424735,0.06223733,-0.048456363,0.083934955,0.04760444,-0.009742268,-0.008155768,0.009070544,0.036319107,0.009664761,-0.06411575,0.026756063,0.03199067,-0.024831975,-0.032926757,-0.017760023,0.044918403,0.06688553,0.14264873,0.054536752,-0.061221585,0.028785292,-0.035853036,1.58257e-34,0.059465412,0.031813316,-0.015349509,-0.014016319,-0.08137167,-0.014882711,-0.10379011,-0.017574875,-0.068523966,0.07868411,-0.100559436,-0.03559829,-0.03862156,0.061126567,0.0088108,0.0592881,0.049459353,-0.0036181402,-0.03517354,-0.029874159,0.01867561,0.077217594,0.009654716,-0.016494242,0.04285823,0.03963485,-0.087875985,0.06914003,-0.002032126,-0.041023325,0.01308178,0.010524949,-0.042486176,0.07295235,0.05098091,0.033136018,-0.0015484974,-0.035960793,0.032084018,0.013478944,0.03129843,0.02419418,0.07050144,-0.06869181,0.0905923,-0.008758686,0.008669605,0.024922581,-0.025046617,0.07048542,-0.013117015,0.0027113676,0.06509748,0.009030666,-0.03827993,0.0050301966,-0.01424449,0.020786809,0.040249806,0.06266429,0.019522224,0.03635548,-0.020172428,-0.019741325,-0.0047267154,-0.0141936075,-0.09064225,0.010802163,-0.05730415,0.10151895,-0.03856694,-0.0016201646,-0.033913545,0.05936854,0.055556577,-0.06389161,-0.09215878,0.04148503,-0.022476142,-0.0045690965,-0.053364713,-0.0024566343,-0.040925596,-0.011587118,-0.11174922,0.033938095,-0.05957649,-0.13385543,0.004081189,0.057741933,-0.037145462,0.0021230185,-0.07835698,0.06826197,0.050420325,-2.9225385e-33,0.08669235,-0.07004085,0.08323306,0.008619513,-0.05317611,0.081622966,0.03750732,-0.037212227,0.013529463,0.021199599,0.02204803,0.06871394,-0.10057921,-0.08720581,0.04469041,-0.019458385,-0.049077563,0.10482889,-0.007839281,0.033030223,0.026685866,0.11143339,-0.003189012,0.018782604,0.077300854,-0.06492693,0.080725506,0.07903595,0.00827116,0.00045168414,0.008561615,0.0021058593,0.032828297,-0.022894926,-0.06729822,0.004759705,0.007939655,0.00859308,-0.013744567,0.022229139,0.016831987,0.050427128,0.0046102675,0.003945784,0.083914414,0.038506582,-0.053747702,0.025196694,-0.00014742477,-0.056980383,0.033346467,-0.032895364,-0.02110876,0.022986863,0.034580912,0.018872924,0.032851245,0.027947178,-0.055983644,-0.01278449,-0.02631286,-0.0014465956,0.0033439426,-0.048874233,0.06630981,-0.033317488,0.012071601,0.007424717,-0.025132312,0.07402905,-0.018285012,-0.04904979,-0.0023564561,-0.017352987,0.03284381,-0.10658007,-0.09267125,-0.041270394,-0.012481332,-0.10065295,-0.014641334,0.012428426,0.031189928,-0.0005944217,0.016042644,-0.029614449,0.056796983,0.07000026,0.023640383,0.044578996,-0.07069052,0.00019853478,-0.008072065,-0.0024539384,-0.009361779,-4.4937476e-08,0.047016773,0.021425527,-0.06509393,-0.060726766,-0.021877022,0.009624186,-0.068113424,0.05229181,-0.01478293,0.022432014,-0.06264581,0.10346169,-0.03343913,0.010504279,-0.052143164,-0.039203566,-0.026211867,-0.034511987,-0.0008899531,0.0017739631,-0.08530748,-0.031512816,-0.07056104,0.067875974,-0.003623417,-0.10021761,0.028000979,0.14319544,-0.009121827,0.005351816,0.020494897,0.020788148,-0.064996324,-0.06107187,0.0012960938,0.059553526,-0.04393985,-0.039768368,0.054313224,0.057930123,0.056323245,-0.04013566,-0.044321965,0.011781988,-0.029861031,-0.051906735,-0.011217242,-0.06693117,0.0061267433,0.062147312,0.008827891,-0.04031398,-0.09364867,-0.039948735,-0.0031272501,-0.08190443,0.031361055,-0.027787935,0.06151294,-0.08020993,0.057117585,-0.034945354,0.12199613,-0.062113814 +2.4.1.143,"The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. Its activity initiates the synthesis of the second antenna of di-antennary complex N-glycans. While the natural substrate (produced by EC 3.2.1.114, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) is described here, the minimal substrate recognized by the enzyme is alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-R.",384,0.99999994,-0.03768036,-0.027966954,-0.06698637,-0.059733927,-0.021937761,-0.021281464,-0.022473179,0.005349296,-0.021284943,0.08224872,0.0642909,0.073599026,-0.06050516,0.013347465,-0.063808076,-0.09444483,-0.0055686818,-0.07497456,0.0026440846,-0.03706533,0.033630434,0.029426565,-0.0035717916,-0.02990812,0.007782289,-0.04162766,0.0063873,-0.0475931,0.039791487,-0.08046256,-0.026827158,-0.043152563,0.0574297,-0.02084261,-0.0092491815,0.049913187,-0.014197324,-0.04964378,0.014556988,-0.01227064,0.012940277,-0.084675685,0.012441424,-0.009658637,-0.09899186,-0.037842438,-0.042855065,0.0034617374,0.08893412,-0.0009150648,0.005189054,-0.042350758,-0.037987377,0.009886595,0.05517024,0.032514658,-0.10184348,0.038709357,0.020902311,0.079884775,0.08974134,0.012343248,0.024944866,-0.018590415,-0.010413141,-0.026967444,0.0023639814,-0.07151155,-0.010763379,0.06318375,0.010162326,-0.03753729,-0.030418806,-0.048228648,0.0072165118,0.060110096,-0.059939828,0.019959392,0.036480326,0.034900706,0.0048972457,0.046164844,0.059335146,0.07716989,-0.10105589,0.029171428,-0.049888425,0.062199187,0.06536072,-0.044808663,0.047387656,0.011527214,-0.024880808,0.03703375,-0.072262734,0.032306314,0.007767411,0.045346934,0.010950026,0.02015902,0.008527751,0.011857094,0.018979263,-0.07580454,-0.12404654,0.041346144,-0.06889195,0.009569108,0.024511192,0.030831065,-0.027308648,0.08628975,-0.015810873,0.03507728,-0.14263591,0.022348817,0.049590707,-0.07814454,-0.028829683,-0.052836534,0.05178075,0.002716761,0.052690096,0.07574636,0.0020990933,0.061916146,-0.013042437,-3.7910303e-33,0.049162745,0.022500174,0.018008092,-0.0030130488,0.04280272,0.013462685,-0.036036275,-0.026046855,-0.052416965,0.028983435,-0.08482871,0.019534253,-0.05244275,0.15253499,0.0139077995,0.13513051,-0.060293254,-0.054480817,0.033968657,-0.00027169747,-0.009266429,0.01184931,-0.031593334,-0.0114231855,0.12713861,0.06558993,-0.062144317,-0.010317019,0.056753993,-0.033825785,0.0779949,-0.09059524,-0.066098794,0.029708894,0.046209555,-0.011363079,-0.051596593,-0.03045583,0.008744636,0.049718812,0.058149617,0.0404804,0.02882008,0.0071150437,0.077379264,0.028821923,0.007181318,0.052747447,-0.012639406,0.050619394,0.056158833,-0.017549789,0.02058394,0.0114316335,-0.014115093,0.054668296,-0.034372922,0.010538435,0.022087423,0.0979681,0.014590626,0.014265284,0.077025354,0.032058477,0.024516929,0.027966272,-0.07753084,0.021364385,-0.015439225,0.024184654,-0.019690787,-0.025032148,0.039005127,-0.021890832,0.0014651272,-0.063018925,-0.007738348,0.034723688,0.0033473058,0.02152778,0.041267917,0.01996831,-0.041084863,-0.034704603,-0.068952926,0.055622946,-0.03020604,-0.119496725,-0.0026632068,0.07511979,0.023878511,0.04748435,-0.09474111,0.022962024,-0.050544113,-8.275232e-35,0.07944282,-0.10968974,0.06254606,-0.04006675,-0.055215493,0.0008637528,0.040788423,-0.013745591,0.029174374,-0.01864161,0.02708895,0.046096895,0.020993095,-0.0046439683,0.0003631416,-0.014393351,-0.04266081,0.10091987,-0.016081875,-0.0067376117,-0.087245144,0.081200644,0.04621264,-0.028018825,0.045376018,-0.05412646,0.06400427,0.061987683,-0.0037126613,0.049693927,-0.004703581,-0.010691551,-0.032022577,-0.028342247,0.04036966,0.026497997,-0.03938174,0.021916455,0.050266545,-0.032800842,0.005437342,0.085671574,0.07106854,-0.03171557,-0.010493353,0.07440883,-0.08942115,0.041914064,-0.10023164,-0.005466972,0.0068815635,-0.03118049,-0.0030595625,0.03890994,0.07292147,0.09124723,0.08698197,0.013069792,-0.012558115,0.025950408,-0.015822956,-0.064242415,-0.009798654,-0.05496804,0.042754505,0.08257894,-0.07197009,0.054017343,0.03307063,0.06410947,0.027387163,-0.06805501,-0.019367987,0.013541009,-0.048544653,0.056638926,-0.075770825,-0.0075106076,-0.037704684,-0.03284042,-0.005286642,0.022628801,-0.019465037,-0.05361952,0.086824805,-0.0070245173,0.08473101,0.12454371,-0.0071540913,0.099191844,0.011134824,-0.04726048,-0.07683392,0.061010912,0.06979743,-4.4211816e-08,0.020916803,-0.050393637,-0.04535027,-0.15165704,0.007301408,0.005714141,0.016410658,-0.029999379,-0.008104636,-0.030524084,-0.037874956,0.0124026,-0.035952765,0.043609615,0.00033565468,0.063064486,-0.0644273,-0.00862874,-0.0533274,-0.04413828,-0.11587654,-0.011020499,-0.080364704,0.06538222,-0.045167148,-0.0495671,0.0992073,0.038187068,-0.054697484,-0.009691113,-0.032327443,0.04268136,-0.035227105,-0.05205269,-0.036060493,-0.028644986,-0.0382524,-0.03446755,0.052911144,-0.03676274,-0.043116186,-0.025369048,0.018463053,-0.055231657,-0.054728445,-0.027327916,0.022853926,0.033534765,-0.02229213,0.086725615,0.032437272,0.010221072,-0.01928631,-0.15111989,-0.12442114,-0.050476715,-0.05041808,-0.013065081,-0.049432863,-0.0613609,-0.053359266,-0.007608313,0.110806294,-0.041225344 +2.4.1.144,"The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. The residue added by the enzyme at position 4 of the beta-linked mannose of the trimannosyl core of N-glycans is known as a bisecting GlcNAc. Unlike GlcNAc residues added to other positions, it is not extended or modified. In addition, its presence prevents the action of other branching enzymes involved in the process such as GlcNAc-T IV (EC 2.4.1.145) and GlcNAc-T V (EC 2.4.1.155), and thus increased activity of GlcNAc-T III leads to a decrease in highly branched N-glycan structures.",384,1.0,-0.007168162,-0.020931687,-0.06548019,-0.07787181,-0.013721759,-0.030995717,-0.02526777,0.068610184,0.054755986,0.037972406,0.04323762,0.08168637,-0.0018600107,0.021599663,-0.098056495,-0.1070373,-0.02702989,-0.04910003,-0.001090358,-0.06717031,0.09610851,0.04917356,-0.009188819,0.014571273,-0.023790201,-0.07878101,-0.034363154,-0.03453924,0.03987388,-0.05855687,-0.056704484,-0.05114669,0.050541185,-0.026994692,0.026467163,0.035581585,-0.03428901,0.03528416,-0.0018339823,-0.003233856,-0.030609837,-0.062816806,-0.03815814,-0.010319766,0.014832949,-0.030767817,-0.009478146,-0.03245951,-0.006083736,0.07075057,-0.013862708,-0.05768042,-0.05387337,0.024359502,0.091479756,0.05138172,-0.13382474,0.01707424,0.07843164,0.096307,0.06603862,0.024360992,-0.02830584,-0.053959902,0.034871258,-0.027252018,0.11274953,-0.062065817,-0.01754199,0.024545807,0.03967388,-0.023796415,-0.0277602,-0.06312589,0.008052981,0.035407446,-0.06440808,0.028747058,0.00055124756,0.0037793992,0.023648154,-0.014021509,0.05702867,0.04806835,-0.09686662,0.017690398,-0.074212186,0.038275838,0.06742032,0.020170398,0.08048676,-0.037228473,0.018141655,0.018467246,-0.004083267,-0.011168003,-0.025444416,0.003884594,0.06279353,-0.032782983,-0.0036955017,0.006785989,0.030483112,-0.07965957,-0.06762966,0.08952199,0.010873486,0.021267187,0.06996723,-0.0130644245,-0.032441657,0.11315996,0.01651016,0.024860065,-0.12185023,0.032876365,0.03229831,-0.07360998,-0.042431083,-0.04258413,0.019039225,0.039079398,-0.024612464,0.051344708,0.029633908,0.046596922,0.0025533824,-9.996424e-34,0.07712911,0.053809524,0.020591829,0.009949638,0.0017108623,-0.026538333,-0.039201066,-0.036110632,-0.059905622,0.012303787,-0.01739825,-0.0130898515,-0.050674796,0.12389593,-0.056999948,0.087774344,0.015022769,-0.026197936,0.015111305,-0.0023318285,0.025728261,0.050796855,-0.0022634591,-0.04382075,0.105547644,0.061859645,-0.07259314,0.0056661824,0.03675598,-0.021208286,0.026836881,-0.11702052,-0.054522436,0.044861034,0.08963507,0.05277037,0.010416964,-0.014832528,0.039324947,0.040891897,0.039881293,0.0113874795,-0.020419054,0.01086857,0.03180668,0.016185077,-0.018972041,0.062631235,-0.038099222,0.092818595,0.07264423,0.0047142105,0.018952193,0.041082837,-0.11240933,0.061684795,-0.013722522,-0.06367448,0.009916033,0.0681108,0.048604265,-0.016597196,0.005112536,-0.05749233,0.051176183,0.055701703,-0.12149541,0.031014375,0.02852731,-0.021088794,-0.067804754,-0.049955264,0.08658988,0.01902074,0.0036050016,-0.041171663,-0.03653868,0.03627276,-0.014249287,-0.01546666,-0.009938021,0.0029145076,-0.03272813,-0.038570754,-0.091727465,0.05149671,0.03903908,-0.12989295,-0.0065786946,0.012802213,0.020456547,-0.025615634,-0.052619018,0.048078965,-0.029866898,-2.3814985e-33,0.11467515,-0.12963833,0.06402051,0.032753218,-0.041360766,-0.02000537,0.025222942,-0.08074309,-0.025715565,-0.09305141,0.049777877,0.021070885,0.035668053,-0.030896297,0.013558361,0.000109717126,-0.005614568,0.09148396,-0.030639593,-0.062348727,-0.065259695,0.02986845,0.013519487,0.015012879,0.04038674,0.024172122,0.025052844,0.021328922,0.028635954,0.058268476,-0.026938377,-0.020095041,-0.015324504,-0.08750438,0.04554059,0.023984527,-0.034214675,0.029578203,-0.004225455,-0.06896264,0.016781008,0.04483144,0.056246407,-0.024188092,0.017137207,0.1361295,-0.010386089,0.033155244,-0.04582102,-0.026175078,0.09837935,0.04391037,-0.010044346,0.05414506,0.08892575,0.09846812,0.05345012,0.015698371,0.00042046604,-0.006763062,-0.030479884,-0.03621051,-0.024068957,-0.048745822,0.09488478,0.034520555,-0.06387371,-0.0022220698,0.051650625,0.0039324393,-0.027557671,-0.047972072,0.02731364,-0.030831039,-0.08469999,0.030362444,-0.084239416,-0.10433576,-0.03373423,-0.04779782,-0.0780937,0.009802738,0.022714563,-0.06303202,0.002445206,-0.06568211,0.04200843,0.13077764,-8.094524e-05,0.009275124,-0.04895898,-0.06091594,-0.06393896,0.03099031,0.04751858,-4.083366e-08,0.048625175,-0.008616903,-0.0849752,-0.056850452,-0.0221792,-0.011558255,0.008280627,0.064738624,0.008091843,0.0027120316,-0.014375496,0.0027679745,-0.03485097,-0.02407328,-0.018899733,0.04782218,-0.04618829,0.004164731,-0.042624198,-0.042292114,-0.17525156,-0.009619257,-0.10660105,0.023918975,-0.027521962,-0.044933766,0.022516364,0.10835397,-0.02187913,-0.020248814,-0.0042674933,0.05424767,-0.024631875,-0.04753059,0.0010401169,-0.01684602,-0.026742494,-0.0032671688,0.050229046,0.0026228451,-0.011309992,-0.03479932,-0.01919849,0.00504866,-0.06580076,-0.017882176,0.04012776,0.044911087,-0.013229892,0.099920414,0.025750348,0.042492785,-0.030160818,-0.07731168,-0.092471965,0.0013700818,-0.0025400086,-0.015487387,0.01590731,-0.02659051,-0.03308091,-0.07987713,0.10827202,-0.063770205 +2.4.1.145,"Requires Mn2+. The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. By adding a glucosaminyl residue to biantennary N-linked glycans, it enables the synthesis of tri- and tetra-antennary complexes.",384,0.99999994,-0.068578035,-0.030739238,-0.047037795,-0.025383703,-0.018828461,-0.028764961,-0.0031284448,0.004087075,-0.01653667,0.034957077,0.09310947,0.017014336,-4.9907314e-05,0.05125458,-0.0235493,-0.021957487,-0.04181801,-0.058898564,0.0008742967,-0.04980265,0.05812342,0.037134945,-0.02250394,-0.09896534,-0.0070291106,0.03561725,0.015876153,-0.06632146,0.077590056,-0.013901925,-0.021086434,0.04045332,0.013262032,-0.083002545,-0.006618059,0.053518053,-0.014194399,0.004483313,-0.012461244,0.006491382,0.007510591,-0.04754051,0.037913896,-0.03140178,-0.052236546,-0.07906765,0.05482371,-0.07134636,0.002851083,0.03962712,-0.039890207,-0.021396209,-0.039751146,0.030349754,0.044154722,0.07665108,-0.12104658,0.05489211,-0.015809601,0.018691594,0.08613678,-0.043938756,-0.029697884,-0.044656537,0.05498861,-0.026573325,0.016373938,-0.046925955,-0.021569176,0.057505105,0.025749914,-0.009988872,-0.03616559,-0.016330993,-0.015255022,0.061711643,0.017666755,0.027574714,0.03018155,0.033390407,-0.039743517,0.015239982,0.07649435,0.08579786,0.01862932,0.07618528,-0.050219554,0.07386389,-0.051331863,-0.031013336,0.046188723,-0.0029627525,-0.060458638,0.022051385,-0.043205295,0.055766497,-0.016287008,0.007151552,0.0327373,-0.0017616865,0.004424718,-0.0025289087,0.024457797,-0.057545945,-0.053052217,0.009972628,-0.01686697,0.08623261,0.049713116,0.024733895,0.013129784,0.0936608,0.06660551,0.05945048,-0.067610696,0.074418806,0.032527607,-0.07337819,0.023629347,-0.05328631,0.07954154,0.04096575,-0.055751342,0.10067258,-0.011688827,0.030090483,-0.06374548,6.903162e-34,0.07123858,0.090619385,-0.023927579,0.015828945,-0.03184689,-0.0023211224,-0.07110019,-0.048011523,-0.015074602,-0.0022020307,-0.0600493,0.002160234,0.021941034,0.13229227,-0.004219201,0.019613076,-0.035465457,-0.06273336,0.13070889,-0.04302732,0.0145398015,0.030984705,-0.02445224,0.0057311156,0.00692858,0.123747595,0.044004742,-0.050438646,0.02927508,-0.033202317,0.02808091,-0.12433386,-0.030995788,0.046683207,0.09609395,0.022127217,-0.01782233,-0.041162293,-0.0070342473,0.032541096,0.032490507,0.015721872,-0.06748925,0.092354916,0.08161322,-0.04998011,-0.04760267,0.040024865,-0.02454098,0.041822374,0.027803667,0.01430216,0.0029100415,0.024282372,-0.091250345,0.06481029,-0.017440367,-0.02129359,-0.0061708856,0.03278088,-0.025084533,-0.024743732,0.042378332,0.108660236,0.07139745,0.018558873,-0.050533347,-0.08729527,-0.010260864,0.020810438,-0.0106731225,-0.034937266,0.08131651,-0.026384966,-0.031949237,-0.043267787,-0.02791045,-0.016619114,0.039915986,0.044260632,-0.0008421653,-0.028336994,-0.0035079573,-0.052318405,-0.070058085,-0.015081849,-0.00070428126,-0.13013393,0.048036627,0.011592878,0.041547716,0.037792232,-0.082780994,-0.0026846696,-0.021304935,-2.4840433e-33,0.05048928,-0.06735554,0.02825038,-0.05858189,-0.10821993,0.019077634,0.008814205,-0.13897307,0.014837125,-0.024475688,0.06748609,0.027389085,0.0098835565,-0.032955367,-0.003650823,-0.01502428,0.005489393,0.062888,0.06319795,-0.068403885,-0.009377062,0.061825093,0.020276615,0.060926955,0.0022179778,0.030206203,-0.0044428953,0.004440469,-0.033066902,0.06261281,-0.03618692,-0.073099576,-0.029219557,-0.063627705,0.096664324,0.075562276,-0.036377367,0.035301816,0.026101064,-0.045179714,0.06568986,0.009548404,0.06928275,0.054120768,-0.047917742,0.0130213285,-0.08324642,0.04649553,-0.09404755,-0.028766645,0.0093080085,0.020571008,-0.05740179,-0.07781872,0.073552966,0.042219028,0.09022214,-0.050842162,0.011253323,0.012325541,-0.0543607,-0.06475792,-0.010952457,-0.05230613,0.07045382,0.07703073,-0.014499032,0.027049253,0.050252948,0.07913926,0.035223212,0.012683732,0.020944763,-0.0057362453,-0.05892665,-0.008962408,-0.054524213,-0.01913479,-0.032365125,-0.0635804,0.015234621,0.026645288,0.005471445,-0.09072838,0.068051495,-0.050445445,0.019023353,0.16632019,-0.0011842288,0.0025905264,0.015380421,-0.065137215,-0.06846251,0.022836119,0.040063478,-3.7066812e-08,-0.028423602,-0.04296805,-0.088691525,-0.107529335,-0.042026587,0.022600986,0.019511387,-0.0011734174,0.028636275,-0.018995725,-0.0004231242,-0.03016114,-0.052552003,0.018124754,0.074710235,0.090022095,-0.016024476,-0.005643581,-0.04633477,-0.11533078,-0.086462095,-0.027778815,-0.10197677,0.091565825,-0.03199913,0.009503596,0.057317577,0.06951754,0.018332237,0.003118413,-0.00987944,0.012450242,-0.034949888,0.0023291265,-0.06336367,0.035794172,0.02183489,-0.032141928,0.002986702,-0.027208975,-0.10344741,0.083961464,-0.02027487,-0.0058820564,-0.03339132,-0.061199084,0.046587303,0.015084356,0.009640009,0.03766031,-0.021598317,-0.03607683,0.026015323,-0.13015868,-0.13130754,0.007992739,0.007119141,0.015418862,-0.0039707846,0.013775515,-0.04294522,0.061434492,0.08402407,-0.09137817 +2.4.1.146,The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.,384,1.0,-0.024259761,-0.08567433,-0.078534484,-0.0049401927,0.031387042,-0.044920854,-0.07133916,-0.007401424,0.041554987,0.06223074,0.005420034,0.1107479,-0.034856934,-0.033355262,-0.073370025,-0.00930146,-0.015956955,-0.057127997,-0.009694762,0.0024031317,0.10416527,-0.03154219,-0.015149357,-0.062372353,0.019208599,0.042162582,0.010824394,-0.0074675065,0.0074378066,-0.079116404,-0.017832156,-0.08207259,0.0674479,-0.0015245749,0.0730208,0.022049313,0.008630274,0.017365415,-0.023714086,-0.009097874,-0.025140783,0.019033866,0.034768693,-0.010732978,-0.03043012,-0.07106103,-0.006110066,-0.015634598,0.05563751,0.06922378,0.053790193,-0.048462614,-0.054248855,-0.0031888545,0.067499794,0.08931252,-0.13482475,0.04321516,0.0042893784,0.058358993,0.07909197,0.06870063,-0.0218826,-0.02544086,0.00053410913,-0.061092105,0.07552011,-0.0369716,-0.096126124,0.039628353,-0.0040248926,0.044055708,0.029842762,-0.029929794,0.08428117,-0.0043741325,-0.050795577,0.031809747,0.06972782,-0.018850662,0.058026504,0.06635033,0.07631987,0.10363036,-0.091265775,0.039830476,-0.0024082947,0.0019514922,0.027297245,-0.021550922,-0.038837478,-0.0820635,-0.015932601,-0.048487257,0.029124357,0.0046720747,0.054564048,0.037807636,-0.025212986,-0.030097006,-0.023696285,0.044477444,0.02253547,-0.095501825,-0.075566456,0.03522407,-0.033176765,0.080541044,0.07622836,0.013119405,0.021719718,0.08760346,0.027545922,-0.014768861,-0.08916618,0.03166326,0.012433083,-0.016967924,-0.06234677,-0.05521359,0.060330834,0.060457096,-0.00030707088,0.097917646,-0.05915302,0.006873047,0.042836078,-2.4810351e-33,0.08307586,0.09698613,0.030207548,-0.0524374,-0.032576013,-0.05969368,-0.054705106,-0.016684115,-0.02377269,0.026107656,-0.07823846,-0.033469632,0.030753205,0.098091885,0.032999836,0.063737385,0.0011060326,-0.059377193,0.04225123,-0.005015831,0.05725998,0.11328595,0.0035063885,0.042856406,0.02893158,0.020874023,-0.025801567,0.0077153062,0.044973306,-0.030304499,0.015632631,-0.053111225,-0.0637981,0.031982504,0.036674976,0.01839643,-0.013412244,-0.023856953,0.07183636,-0.01965074,0.038111005,0.014372038,0.027923193,-0.0040140226,-0.008138998,-0.00096041604,-0.0132729765,0.0042140936,0.0052162632,0.05853491,0.04108705,-0.0072762063,0.03705557,0.05326161,-0.14750952,0.0619623,-0.048178475,-0.08759824,0.0049005006,0.086560085,0.029782325,-0.035925068,0.022216087,-0.0013190428,-0.065903515,-0.002611101,-0.04846873,0.0033669556,0.04306976,0.06417158,-0.03356975,-0.040909886,0.04707049,0.053104967,-0.03338883,-0.04595124,0.033548716,0.045335144,0.018374836,-0.010788933,0.012720857,0.010302526,-0.020474212,0.023759475,-0.03986569,0.05809211,-0.0503851,-0.07410889,0.014665991,0.11351712,-0.09220679,-0.07294256,-0.028924825,0.017763963,-0.0602116,-9.718082e-34,0.09074224,-0.13201998,0.06263724,-0.027977023,-0.0930542,0.033104833,0.0025735968,-0.05403319,-0.035436224,-0.033186264,0.04299018,0.049869824,-0.022225497,0.0051420163,0.01853512,-0.02260916,-0.08493115,0.08533909,-0.0017395746,-0.017087096,0.0041485517,0.010927598,0.0015795274,-0.038586438,0.08942304,-0.011852011,0.012884157,-0.018543107,0.015236125,0.0946172,0.020847384,0.0034764346,-0.00447712,-0.017732112,-0.013685637,0.076739356,-0.011540622,-0.033407234,-0.06793305,-0.027578034,-0.012272948,0.03461584,0.044565193,-0.00093535933,0.08582425,0.058733847,-0.05540307,0.002197817,-0.09423473,-0.019208472,0.042351197,0.010527084,-0.032200567,0.0068617314,0.06030637,0.078207254,0.02216535,-0.007149959,0.019878212,-0.010482859,-0.08801128,-0.013342461,-0.027780887,-0.061562728,0.09116438,0.00129812,-0.0007806876,0.017240815,-0.05578685,0.023830887,-0.04357028,-0.04798016,0.040640566,0.04338354,0.0432712,-0.009000191,-0.07556028,-0.04917393,-0.006263549,-0.030545413,-0.022324637,-0.0034530004,0.038525093,-0.019873166,0.022119831,0.02037564,0.085043795,0.15567793,-0.0065602195,0.0732798,-0.04086298,-0.022584938,-0.034075882,0.013180435,0.011832091,-2.8089692e-08,0.049636398,0.0043573123,-0.012259742,-0.07203023,-0.0589964,0.038488258,0.01524192,0.052872494,-0.025798168,-0.038724747,-0.036652163,0.05061749,-0.003978417,-0.05875488,-0.10166955,0.08299063,-0.021386707,-6.0120383e-05,-0.020429788,-0.01812083,-0.17886478,0.01325429,-0.11351603,0.090029635,-0.027663099,-0.062272895,-0.018231157,0.055868816,-0.05752825,0.03505209,0.012089661,0.03921805,-0.05220581,-0.105536416,-0.04755619,-0.026891079,0.014882872,-0.0059301206,0.06459784,-0.025343692,-0.014436335,0.023095794,0.02697763,0.0064881863,0.016534721,-0.018780848,-0.021966012,-0.010529087,-0.038447727,0.06861185,0.0051654372,-0.030440588,-0.038954493,-0.10798169,-0.12898982,-0.08194649,-0.045144074,-0.06755609,0.026449692,-0.046618603,-0.058261774,-0.016201532,0.104205824,-0.005456759 +2.4.1.147,"The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans. O-Linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue.",384,1.0,-0.055792395,-0.10064516,-0.05459131,-0.006774784,0.0798476,-0.059983596,-0.009881786,0.073210336,0.087217614,-0.024476508,0.056304045,0.05966578,0.015167347,-0.0074985013,-0.05260117,0.018306829,-0.041081566,0.019845435,0.022652252,-0.025416294,0.14314435,0.008441648,0.011435131,0.0013861676,0.04915254,-0.029614259,-0.02306425,-0.00903001,0.008746641,-0.07855106,-0.020756695,-0.07644531,0.025905777,0.018568385,0.06420381,0.05205335,-0.008079646,-0.012718242,-0.0570826,-0.0036553915,0.04873817,-0.021823307,0.04223198,-0.037045486,-0.017525049,-0.045790017,-0.018334717,-0.020331992,0.044577222,0.039996643,-0.041830033,-0.09816401,-0.094394535,0.025079668,0.07899137,-0.009766291,-0.13654435,0.0081544,0.031035867,0.07220155,0.080030076,0.027561571,0.0095486,-0.038483582,0.036046397,-0.051701415,0.07774981,-0.05975347,-0.10731011,0.06295349,0.007037493,-0.010248568,0.0108459145,-0.022970304,0.083710134,0.05877028,-0.043028466,0.0023231816,-0.0060496014,-0.01702663,0.018406745,0.0855745,0.011105741,0.10874622,-0.06376881,0.01350069,-0.010075685,-0.00087139226,-0.040713165,-0.030687619,-0.02757081,-0.039915606,-0.042121127,-0.04773217,0.030703584,0.015389698,0.018857578,-0.012503051,0.028713183,0.024749795,-0.041608505,-0.0024093797,0.07673595,-0.10612646,-0.10590638,0.021801475,-0.048632786,0.0654319,0.02927231,0.0021873498,-0.020199398,0.0024615326,0.0011942363,-0.04577007,-0.079172574,-0.002700473,0.04841392,-0.04422205,0.009285938,-0.007862468,0.027587157,0.029244024,0.05568496,0.035458792,-0.07235742,0.009071796,-0.034671918,7.695151e-34,0.076295,0.045154065,0.0062094457,-0.021582842,-0.04878095,-0.030666357,-0.01858435,-0.035482965,-0.100426905,0.015283405,-0.08878356,-0.024504006,0.019012325,0.115671396,0.017699031,0.002178696,0.01222691,-0.05579623,-0.007151611,-0.012998854,0.038553458,0.09066763,0.0011793001,0.051537316,0.052302387,-0.021161696,-0.030806597,-0.0367074,0.058666743,-0.02640507,0.04489511,-0.01821954,-0.05948575,0.008512742,0.029354844,0.04260712,-0.033485435,-0.051445898,0.041615095,0.022533515,0.016962513,0.0120341815,0.038400546,-0.0052199652,0.04092689,0.039926205,-0.00024403006,0.0047501563,0.0134194195,0.018768895,0.08769783,-0.019655138,0.04619611,-0.002357567,-0.115033135,0.049753755,-0.04454115,0.011400073,-0.033283327,0.06474971,0.03364582,-0.025598042,0.016353322,-0.032870725,-0.07060651,0.055075396,-0.121137425,0.021657078,0.068527535,0.08433974,-0.049044084,0.0027703228,0.031755734,0.074111804,-0.010199957,-0.029164553,-0.0772466,0.0047333795,-0.011265647,0.0046391487,0.01940704,0.039081533,0.008231948,0.007725679,-0.085665286,0.054741085,-0.068901,-0.038133476,0.0049083056,0.11921924,-0.03883477,-0.051103782,0.021522889,0.051257882,-0.12730876,-2.6342402e-33,0.043019887,-0.11145539,0.11876717,0.004528437,-0.03725379,0.034173362,-0.028195284,-0.015751312,-0.02089401,-0.025870122,0.08091195,0.0004061486,0.04209799,-0.04795898,0.042272527,0.029151147,-0.09840389,0.053957626,-0.019187551,-0.02246319,-0.017009752,0.0008947328,0.05159422,-0.040479552,0.03868638,0.020679189,-0.006135999,-0.0035886473,0.068450525,0.060122352,-0.046971157,0.0031244683,-0.03889126,-0.020074533,-0.06827023,0.035463896,-0.040842168,-0.06473489,0.017743452,-0.04681695,0.011259683,0.041982234,0.080296144,0.03194975,0.040539872,0.09889657,6.177987e-05,0.0320768,-0.0355045,-0.017470641,0.0044703186,-0.02400616,-0.0041087964,-0.008175131,0.024307678,0.09625433,0.018018229,-0.02973786,-0.017950933,-0.044815306,-0.05088111,-0.07365606,0.032142166,-0.0073330607,0.10101708,0.042664647,0.015149235,-0.033465307,-0.04546278,-0.004425052,-0.002217368,-0.016657457,-0.034008544,-0.04095459,0.06263697,-0.0022745652,-0.1759505,0.0022856274,-0.023972262,-0.020028755,-0.033374876,-0.005760248,-0.0065192343,-0.02676106,0.08932694,0.004655293,0.056529418,0.1326664,0.07795653,0.029962089,-0.043189146,0.014264256,-0.013374604,0.05820284,0.017765773,-3.9321495e-08,0.07084855,-0.036120977,-0.046574604,-0.061816383,-0.06669723,0.017348683,0.0071077617,0.035727106,-0.012142491,0.03841828,-0.023419417,0.026248282,-0.08176306,-0.08104369,0.0012629178,0.039704338,-0.022052472,0.025597552,0.008309373,-0.041429833,-0.13947129,0.018576505,-0.07677507,0.15087631,-0.027241368,-0.012510388,-0.0005347101,0.057022795,-0.03756509,0.037453968,0.017566947,0.04329923,-0.034735534,-0.068731695,-0.08925231,-0.01706831,-0.028939726,0.02033252,0.006172546,0.029909959,0.07771314,0.006177687,-0.025745185,-0.017763749,0.0040748646,0.02836165,-0.032588154,0.034975387,-0.079126455,0.016220853,-0.01002132,-0.011495916,-0.059820782,-0.009246361,-0.10415602,-0.08724479,0.030912027,-0.07555171,0.05080147,-0.09549357,-0.047944043,-0.023605403,0.18391053,0.04140809 +2.4.1.148,"cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase).",384,0.99999994,-0.06551848,-0.06479439,-0.13975208,0.035315786,0.013863505,-0.0045618447,-0.047825385,0.07356859,0.006986148,-0.028440945,0.016981471,0.047742505,-0.015219785,-0.0051505733,-0.103333406,-0.04903286,-0.021930218,0.002615407,0.010171834,-0.01745104,-0.003915042,0.025790269,-0.0016933398,0.009200693,0.07896825,-0.061771996,-0.06301804,-0.042889424,-0.00014952848,-0.07190416,-0.018110326,-0.086013734,0.056889717,-0.020242851,0.09586893,-0.023194978,0.020213373,-0.0361955,0.014959426,0.002701823,0.0020365366,0.0020735331,0.0019614506,-0.020178022,-0.018280342,-0.024427501,-0.04659477,0.039592844,0.05434053,0.04407417,0.061121967,-0.027137553,-0.118947975,0.030527418,0.05318915,-0.0050783264,-0.055971727,-0.06074471,0.03429094,0.11692636,-0.0077403076,-0.007657247,0.016489176,0.014365004,-0.056797992,-0.0703088,0.14798209,-0.039409284,-0.034321547,0.009058147,-0.036491945,-0.013656305,-0.034502614,0.048836406,0.026572669,0.0076827067,-0.042267893,0.05395143,0.046308745,-0.0109655885,0.0335877,-0.023898443,0.0193804,-0.01713206,-0.058029905,-0.056163795,0.02014056,0.07187846,-0.0071286885,0.03819199,-0.014122209,-0.06641977,0.07533252,-0.015958885,0.011895727,-0.006482648,0.09881887,0.019312542,0.015526894,-0.03973915,-0.05832785,0.033291887,0.07675953,-0.042318,-0.02908813,0.048626587,-0.018765658,0.07576967,0.075586624,0.012493778,-0.012673754,0.013302739,0.018250862,-0.036418416,-0.101339094,-0.0017851109,-0.03355696,-0.062593155,-0.003283207,0.029752826,0.03753322,-0.056301367,0.08309333,0.018275604,-0.0017095648,0.05577085,0.02435133,3.0443063e-33,0.039779697,0.049059246,0.09696437,-0.018393846,-0.0030867446,0.0043172487,-0.07081429,0.019568209,-0.00015067769,-0.014897779,-0.042478368,-0.02485004,0.030496363,0.062216617,0.023712056,0.12245628,0.0493904,-0.09088269,-0.011195132,-0.001695199,-0.027182704,-0.0022979446,-0.06171463,-0.016818043,0.08693193,0.03080815,-0.039675895,0.07281468,0.054911837,0.019431239,-0.017180987,-0.10280583,-0.030543284,0.00035492436,0.05264622,0.011301625,0.022325644,-0.08704901,0.09394439,0.021433182,0.03625199,-0.020514676,-0.013955773,-0.009096755,0.01873805,0.048071016,0.024894575,-0.022357302,-0.019020265,0.10806554,-0.04294641,-0.058377065,0.020931995,0.02295691,-0.038187046,0.05592399,-0.06553532,-0.06435733,-0.011366094,0.07944813,-0.0057051014,0.05374516,0.0069280807,-0.047631882,-0.061394047,-0.02365049,-0.098744005,-0.002687539,-0.048857167,-0.03253602,-0.027704021,-0.064370826,0.05711809,0.036432594,0.033235993,-0.05213525,0.03140191,0.060063172,0.020673629,-0.027781036,-0.038336117,0.11488063,0.003631358,-0.024750875,-0.0044861822,0.046229266,0.0068362346,-0.05886594,-0.05210749,0.08023329,-0.033254556,-0.017696895,-0.01850774,0.05221696,-0.060948923,-5.4186183e-33,0.109527394,-0.08440699,0.008755368,-0.0929674,-0.0004709283,0.0680435,0.004750566,0.02148719,0.05314545,0.016758041,0.03625632,0.006868855,0.022093106,-0.10063872,0.057493966,-0.0874141,-0.020679124,0.03527527,-0.052392457,0.06399907,0.025255105,-0.017307315,-0.010795082,-0.00273033,-0.057261515,-0.0013116407,-0.04496788,0.011738499,0.011929037,0.110235766,-0.008615275,-0.007013394,-0.04684064,-0.011041197,-0.06959412,-0.05797188,0.0033632158,-0.026181977,-0.03488927,-0.028125245,-0.0016912839,0.10781777,0.026624463,0.009680304,0.10950819,0.13789302,0.04120399,0.029128265,-0.02132333,-0.05621794,-0.008784032,0.0054197162,-0.05796645,0.14163351,-0.0367948,0.032377146,0.0168328,0.07613274,0.01638051,-0.011748022,-0.03665093,-0.02285098,-0.009087647,-0.027698988,0.056155965,0.016057959,-0.015712285,-0.0031939954,0.050355237,0.04062535,-0.046612535,-0.08599127,-0.061515104,0.04843302,0.03764336,0.021073382,-0.16164407,-0.08998193,-0.04752074,-0.053009175,0.06037932,0.014211622,-0.017492441,0.013744514,0.000657495,-0.023223788,0.05458225,0.10381028,0.0027797816,0.04299015,-0.05225575,0.015891982,-0.091372825,0.05532403,0.010442313,-4.4172612e-08,0.055947244,0.013177129,0.030061252,-0.11589454,-0.031513125,0.016287578,0.008877649,0.03439687,0.0088090375,-0.03311435,0.0070219478,0.04073363,-0.045395568,-0.053227738,-0.08157075,0.06372837,-0.058460865,0.004660057,0.043774668,0.08754239,-0.053892303,-0.0058268304,0.032444585,0.032440078,-0.06293013,-0.0570794,0.13119064,0.08386235,-0.06652682,-0.039865136,0.004603128,0.03790076,-0.08386826,-0.03469276,-0.06675185,-0.06836196,0.041078236,-0.0069991834,0.08581012,0.04744586,-0.010631927,0.0022604,-0.023468278,0.030483697,-0.0005711293,0.020715885,0.036386933,-0.030107237,-0.017386766,-0.011051809,-0.0067307795,-0.055079225,-0.121125035,-0.09482063,-0.06283427,-0.06624887,-0.054428402,-0.018134803,-0.011079943,-0.010766855,-0.0009271931,-0.04424921,0.11111018,0.042224187 +2.4.1.149,"Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on glycoproteins, glycolipids, and oligosaccharides.",384,1.0,-0.023354169,-0.11425058,-0.09726374,0.02286263,-0.0029081313,0.020782717,0.033314012,-0.012718345,0.018728858,0.032791972,0.03443668,0.07505707,-0.026325893,0.043552503,-0.09763549,-0.0055657183,0.062179085,0.024496736,-0.006793131,0.029552793,0.054629702,-0.048043467,-0.020347754,0.012588454,0.06568549,-0.03436203,-0.059646647,-0.05107528,-0.010677089,-0.06917268,-0.017091526,-0.038565103,0.08332263,0.03238638,0.015006494,0.012304926,-0.010065116,-0.03736763,0.016685655,-0.014888071,0.012377769,-0.03301029,0.026085088,-0.014298897,-0.0194771,-0.05002127,-0.028888432,0.06551059,0.10451641,0.055382486,-0.01067788,-0.055622514,-0.052988328,0.001726691,0.050645117,0.02678541,-0.119720116,-0.05311308,0.05049355,0.08514133,0.044996236,0.0028291454,0.019866923,0.054577883,-0.074529186,-0.0523871,0.05965054,-0.021426553,-0.020968104,0.07317839,-0.00436498,0.03502915,-0.026722055,-0.028413875,0.048755042,0.040113185,-0.033618394,-0.0037879471,0.039525278,-0.041273672,0.036009427,0.019729793,0.07408988,0.030039445,-0.0446844,-0.03547897,0.053203106,0.016579129,0.014803257,-0.005088343,-0.0061952244,-0.07014938,0.050524477,-0.032029428,-0.03189464,-0.09151631,0.07470084,-0.061401643,0.0018248166,-0.0375863,-0.05844904,-0.041496694,0.059987757,-0.04026025,-0.06713204,0.08432161,-0.016960388,-0.003995826,0.061222874,0.07302047,-0.05870256,0.0018056948,-0.0014485309,-0.048114385,-0.096398115,-0.015633853,-0.0174124,-0.09568829,-0.03568129,-0.033016752,0.0097961435,0.012155144,0.07120551,0.003333049,-0.04363276,0.09723808,0.052298937,1.2258654e-33,0.07216645,0.054382477,0.08154055,0.0011887931,0.044828262,-0.022659462,0.002953549,-0.010845821,-0.008214058,0.017618643,-0.024836378,0.0022212565,0.045001548,0.12263043,0.034194212,0.10735252,0.03814811,-0.07267294,0.06650486,-0.018733842,-0.060987372,0.032777216,-0.040506102,-0.051805027,0.058450397,-0.01172157,-0.009110427,0.07575003,0.07267759,0.031184584,0.041396756,-0.0612328,-0.07031314,0.011647009,0.072693996,0.064144455,-0.02167984,-0.076183,0.078887634,-0.018861504,-0.01692077,-0.0014107387,-0.05377674,-0.03373994,-0.002623192,0.013697993,0.01684667,-0.019155504,-0.027126148,0.074444085,0.0058329036,-0.047912616,0.003119257,0.06773509,-0.045166098,0.094663315,-0.060679175,-0.041784946,-0.041942894,0.061652623,-0.02917379,0.019270275,0.0031573814,-0.06550795,0.0298236,0.05723552,-0.07542881,-0.042841062,-0.051986154,-0.035532814,-0.032675065,-0.065573364,0.06719892,0.056378912,0.009378039,-0.0062613706,0.06814146,-0.0077730203,-0.023523068,-0.006079726,-0.025413001,0.04676552,0.019307531,0.006709849,-0.04937981,0.04754485,0.022218494,-0.09147625,-0.011407506,0.024625598,-0.029618751,-0.038399406,-0.016501147,0.06430346,-0.0641342,-4.4732993e-33,0.12460475,-0.11635207,0.07529722,-0.015559995,-0.03656215,0.023476725,-0.015432051,-0.051470872,0.05021444,0.010315792,0.03357963,-0.0092370715,-0.027064735,-0.03810048,0.028300134,-0.060548637,-0.039095707,0.068933204,-0.055429835,0.031397603,-0.024867497,0.027487267,0.027738797,-0.03724285,-0.010205293,-0.034832314,0.003489709,0.006544238,-0.019192025,0.0847451,-0.001191278,-0.025207417,-0.06762291,-0.09603211,-0.01414675,-0.003451219,-0.04028993,-0.030550003,0.011996833,-0.057769574,-0.005171717,0.043225594,0.033315115,-0.007200995,0.1270462,0.052461497,-0.053557962,0.02719934,-0.059348963,-0.052390195,-0.034400884,-0.007963155,-0.051385768,0.1115926,0.040552013,0.062072,0.06077139,0.018964784,-0.0068644187,-0.050668612,-0.0395148,-0.018011713,0.015926888,-0.042137887,0.108835675,0.035318363,-0.025346616,-0.0132123055,0.08871727,-0.0072436873,-0.057484187,-0.055175703,-0.030698473,0.08780351,0.01713315,0.015866118,-0.15094885,-0.106176384,-0.03982614,-0.01342932,0.045042202,0.042428814,-0.019294826,-0.043093048,0.034897976,-0.00097153167,0.08092444,0.14472581,-0.014714627,0.038800914,-0.01409783,-0.009588546,-0.01734812,0.040303692,0.01846053,-2.938867e-08,0.061452765,0.06472449,0.048864372,-0.12286204,-0.089281134,0.0033859422,0.0035896492,-0.0008894572,-0.0038303533,-0.051051214,-0.02751552,0.10858293,0.014750464,-0.018101849,-0.06836635,0.08489714,-0.06857601,-0.04765461,-0.0020001677,0.03152855,-0.122011825,0.015999038,-0.04033831,0.044462048,-0.068285696,-0.104877375,0.10032349,0.07493992,-0.06345009,0.011238127,0.029332515,0.059590515,-0.06340563,-0.069073975,0.01115228,-0.029835045,-0.012430581,0.00037315616,0.089114584,0.012325223,-0.017481662,0.029172251,-0.0015920413,-0.011752084,-0.047327228,0.024017802,0.02651802,-0.0013353161,-0.05785434,0.044370603,-0.041066945,0.018132575,-0.11644068,-0.07370161,-0.0782003,-0.047733355,-0.034716737,-0.017658131,0.049943548,-0.029805291,-0.04627522,-0.06512391,0.064958684,0.03632262 +2.4.1.150,"The enzyme acts on poly-N-acetyllactosamine [glycan chains of beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine units connected by beta(1,3) linkages] attached to proteins or lipids. It transfers a GlcNAc residue by beta(1,6)-linkage to galactosyl residues close to non-reducing terminals, introducing a branching pattern known as I branching.",384,1.0,-0.0022896486,-0.08907466,-0.09269025,-0.014137683,0.009190593,-0.014656211,0.037872672,0.007353638,-0.0066777426,0.031994116,0.01665354,0.11706554,0.010748019,0.06008243,-0.103072256,0.018464461,-0.05946207,-0.01841472,0.017338168,0.041325018,0.13060774,-0.007376527,-0.028618362,0.0050641024,0.038656253,-0.009467698,0.01271617,-0.086437695,-0.0063785785,-0.0876169,-0.036734812,-0.014452695,0.024831286,0.009689836,0.029208517,0.06838386,0.022382496,-0.009136908,-0.0072820317,0.031032497,0.051702,0.030470157,0.031947825,-0.027038136,-0.0028319983,-0.040234223,-0.06242376,0.014918279,0.07169162,0.023233222,0.05935244,-0.060218677,0.0038609866,0.06592772,0.034653265,0.078921065,-0.07670524,-0.03468962,0.051618505,0.11324657,0.0811972,0.06391369,-0.006520946,0.0048983176,0.0046089645,-0.079262905,0.06607867,-0.015101663,-0.009655996,0.026473783,-0.027639683,-0.011689424,-0.055747066,-0.048213955,0.08582613,-0.028170671,-0.04946927,-0.0008936115,0.042377584,-0.014195344,-0.019549977,-0.028958756,0.060480267,0.04209554,-0.040039517,0.03672806,0.03776554,0.035877053,0.048586328,0.034720417,-0.024211135,-0.10141139,0.004814787,-0.054299407,-0.048522502,-0.06118222,0.07771412,-0.037439674,0.028687365,0.014532962,0.022159401,-0.023973493,0.038573727,-0.06919721,-0.05676349,0.05697868,0.009152733,0.03175552,0.037746478,0.009375895,-0.07397653,0.058127165,0.04547809,0.02997744,-0.08902943,0.065689094,-0.0148479035,-0.064216405,-0.04987389,-0.015728366,0.045957718,-0.00055244676,0.005361674,0.047036763,-0.037241206,0.064272106,-0.021308225,8.815484e-34,0.07710177,0.06921607,0.07054894,-0.06363338,-0.0018822515,-0.022132883,-0.07235903,-0.062475245,-0.04375087,-0.014693108,-0.049362488,-0.009734974,0.022535885,0.09668196,0.008772278,0.08162642,-0.0028581016,-0.009716511,0.08599364,-0.024623826,-0.039677203,0.047813695,-0.06345472,-0.064163856,0.08437474,0.05863696,-0.046895128,0.062403042,0.07606015,0.021383436,0.003408607,-0.04284907,-0.072204754,0.070849285,0.041755613,0.066776186,-0.012727766,-0.1013328,0.05383897,-0.010209178,0.07037269,-0.027151162,0.0070618847,0.003963885,-0.033239678,0.020803804,0.0015757481,-0.013502369,-0.040990286,0.08301472,0.00236391,-0.026717374,0.010477173,0.012130439,-0.08667291,0.053147584,-0.06748856,-0.05860956,0.0065228306,0.086280204,0.023456747,-0.02166876,-0.03891101,-0.020520544,0.022773337,0.029783204,-0.07042565,0.013173726,-0.0015883436,-0.037283365,-0.09503126,-0.07394251,0.033933003,0.03930241,0.005487089,-0.016712656,-0.021759365,0.014568554,0.004618351,-0.013827235,-0.049210906,-0.020402715,-0.042876825,-0.05888373,-0.013364999,0.027280893,0.055647172,-0.11715797,-0.034380548,0.022637138,-0.0074396897,-0.05706743,0.007941573,0.08316351,0.004737294,-3.6848673e-33,0.10083247,-0.13304049,0.12146544,-0.05060252,-0.032378618,0.021146797,0.058540184,-0.0672875,0.015854962,-0.030260896,0.0100983465,0.020334726,-0.029929703,-0.044849783,0.019677173,-0.0073825493,0.0021076559,0.044290766,-0.021884108,-0.020945976,-0.008606276,0.026268486,-0.0009511414,-0.0069268732,-0.043482065,-0.025406126,0.040257104,0.021566661,0.010468044,0.0665398,-0.008036093,-0.014074099,-0.044524044,-0.052450746,-0.029470308,0.025625793,-0.024191506,-0.043473996,-0.0008511079,-0.03502033,0.0016828447,0.061868373,-0.005048985,-0.009508845,0.08102941,0.10609939,-0.07711443,0.014834007,-0.023128558,-0.061328765,0.0012172032,0.024814645,-0.00044791683,0.05001558,0.026065353,0.06372791,0.050228212,0.058793645,-0.0077243797,-0.068645164,-0.052282877,-0.013093389,-0.046016518,-0.05282293,0.081790425,-0.020065624,0.039385855,-0.013535818,0.021782402,-0.024251774,-0.009028277,0.006987101,0.064344704,0.09143454,-0.012626686,-0.069418766,-0.109197475,-0.10958392,-0.022655668,-0.0720064,0.022708701,0.03831682,-0.010300792,-0.05027462,0.03134508,-0.058517743,0.07747734,0.15814453,-0.011538423,0.015981974,-0.019748224,0.024729673,-0.051092256,0.037714407,0.0649667,-4.1403304e-08,0.063846745,-0.008235138,-0.0251266,-0.110505395,-0.045449533,0.013991735,-0.004712023,0.05131927,0.0017033529,-0.04594796,-0.016156102,0.12698574,0.032757,-7.323033e-05,-0.034699995,0.053901732,-0.031142531,-0.015880186,-0.023082629,-0.009521742,-0.14539646,0.009244873,-0.08167148,0.07660241,-0.054553993,-0.05046329,0.07024884,0.1464665,-0.06925742,-0.0057484177,0.002275377,0.07465665,-0.09564643,-0.05179712,-0.048634473,0.03146109,-0.0058157863,-0.028213432,0.07785884,0.03630879,0.055301506,-0.01167802,-0.024675934,0.011662514,-0.022266276,0.00535535,-0.025422951,0.0105624255,-0.02266895,0.068729214,0.024810635,0.015995797,-0.08390253,-0.11647904,-0.07557084,-0.03629905,-0.06415961,-0.06556882,-0.0010174414,-0.023791084,0.0063109496,-0.061929867,0.124395676,-0.043690722 +2.4.1.152,"Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.",384,0.99999994,-0.004166483,-0.09655636,-0.16071391,0.03404481,0.058157034,-0.018701486,-0.01548335,0.0060291067,0.047978226,-0.030204175,0.034299195,0.06567991,-0.08781169,0.04430319,-0.080401935,0.035106152,0.0009542866,-0.0011322902,-0.034079928,0.009936694,0.07599828,-0.063018896,0.00062618585,-0.0058001443,0.03624611,-0.028556522,-0.038214844,-0.060046684,0.0016627185,-0.1057955,0.010872449,-0.027824836,0.065180965,-0.019255882,0.027078267,0.036507644,0.012460037,-0.029558504,0.037567675,0.034028776,-0.037888374,-0.02965735,0.025392072,-0.036673516,-0.019634947,-0.02483371,-0.011572524,0.04308026,0.05247131,0.05022687,0.0212899,-0.054280903,-0.10395398,0.02813649,0.04687628,0.06263402,-0.10421825,-0.074560784,-0.00027162005,0.08327271,0.04749872,0.045785386,-0.007760855,0.06970258,-0.029401926,-0.06092839,0.10225424,-0.058824085,-0.011286725,-0.011180711,-0.06291037,-0.014671855,-0.012100662,-0.046916265,0.08119292,0.059970453,0.013432774,0.014626595,0.061256424,-0.021855602,0.047206346,0.010973765,0.017832227,0.044905003,-0.031826727,-0.018602531,0.042400617,-0.01569679,0.05105693,0.05538897,0.0018649885,-0.07825498,0.009968475,-0.05207614,-0.026870256,0.008562213,0.08685843,-0.0057758265,0.03503676,0.0016342081,-0.0325783,0.0070498586,0.055738114,-0.04627456,-0.054475743,0.08243902,-0.021702772,0.060239132,0.047769323,-0.010562375,-0.06273811,0.0051189205,0.047764745,-0.00431986,-0.09996643,0.02511079,-0.008127492,-0.08603637,-0.03156672,-0.013917272,0.018617095,0.01036967,0.07847295,0.056194037,0.006809255,0.09872944,-0.028709816,4.9321598e-33,0.12156005,0.080202416,0.066489205,-0.013869167,-0.022916185,-0.016864859,-0.045272965,-0.05473537,-0.043977786,0.026866097,-0.02849635,-0.033173114,0.05016005,0.07451694,0.005943631,0.03526236,-0.007151795,-0.05315952,-0.02423552,-0.006935399,-0.0063205147,0.09917212,-0.049950175,-0.02380905,0.03683475,0.05900295,-0.049169153,0.03405889,0.047462456,0.041938018,0.027157834,-0.09309547,-0.07895443,0.059059415,0.054613158,0.07870257,-0.04633996,-0.10851595,0.06412272,-0.016093876,0.011969418,0.011915302,-0.055478092,-0.02191601,-0.009745816,-0.0181691,-0.017405214,0.051937345,0.019572267,0.105959944,-0.009487406,-0.06039221,0.061087925,0.008857011,-0.028069112,0.013421637,-0.087795444,-0.018612398,0.034895528,0.055848423,-0.00778481,0.07411209,-0.05292347,-0.02658812,-0.013588286,0.0100286305,-0.07521163,-0.07794003,0.0065017086,0.036746077,-0.022030791,-0.05545099,0.0380678,0.05993801,0.037390217,-0.045634426,0.02320982,0.003969565,0.015114872,-0.004124911,-0.011260516,0.020817263,0.013965278,-0.048504215,-0.074215434,0.0017119854,-0.018463457,-0.107518055,-0.042842295,0.063770115,-0.050088912,-0.07943884,0.010056766,0.04021053,0.019774137,-6.7956695e-33,0.11401941,-0.107941076,0.09704215,-0.025664188,-0.07103896,0.019262921,-0.009554862,-0.039586812,0.017159687,0.009033084,0.0029964403,-0.010781401,0.028296245,-0.06225027,0.05174713,-0.081657335,0.019050896,0.0411278,-0.03772565,0.047505498,-0.020314602,0.041073754,0.013607662,0.044012878,-0.003621361,-0.021699395,0.014816969,-0.021091113,0.007015242,0.045359783,-0.045865126,0.01252414,-0.028144209,-0.036300104,-0.04368645,0.0029216518,-0.032808695,0.011306874,-0.01946251,-0.043379065,0.003370792,0.081328586,0.060206726,0.0530298,0.07058285,0.09312541,-0.09550127,0.05389527,0.00979482,-0.013274204,-0.014262964,-0.0019818393,-0.0047444873,0.07205808,0.031843636,0.052252572,0.044723105,-0.034513723,-0.05765964,-0.02752262,-0.06474032,-0.07559224,0.006980898,-0.07145115,0.07615907,0.01243118,-0.009021065,0.028627723,0.050806012,0.017493153,-0.00093812076,-0.0535065,-0.004617954,0.011499745,0.02360988,-0.0496686,-0.14380103,-0.08764895,-0.021971913,0.0063900044,0.044896282,0.007014288,0.052597236,-0.02306205,0.0065059476,-0.051120717,0.043712746,0.15836374,-0.0037991884,0.023838034,-0.04184693,-0.01008744,-0.048810154,0.043930903,0.05553258,-4.9005497e-08,0.055171482,0.01423094,0.099377476,-0.07556694,-0.031577017,0.062323492,0.006667711,-0.02131175,-0.006260628,-0.017392537,-0.012806212,0.13042678,0.013675929,-0.08391211,0.01369006,0.06583694,-0.04184117,0.012856598,-0.013040557,0.014715608,-0.13320316,-0.028581139,-0.06938736,0.06916873,-0.010492726,-0.0516703,0.07647298,0.067187056,-0.06724472,-0.013653304,0.033804752,0.033155337,-0.05690432,-0.036163714,-0.13216832,-0.04652914,0.0012681559,-0.0052348184,0.032245703,0.08098924,0.0114777675,0.057355437,-0.0005772773,0.022139458,-0.06704915,0.017289627,-0.019226259,-0.030928064,-0.07077711,0.02781894,-0.014055575,-0.067248434,-0.13641633,-0.04466171,-0.10010699,-0.050206352,-0.028503217,-0.021733414,0.02741056,-0.044712424,-0.027251849,0.007419423,0.13567881,0.009759284 +2.4.1.153,"The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, initiates N-linked glycosylation in that organism. The enzyme differs from the eukaryotic enzyme, which leaves one additional phosphate group on the dolichyl product (cf. EC 2.7.8.15, UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminephosphotransferase).",384,0.99999994,-0.11056218,-0.048290763,-0.12219854,-0.009880059,0.006314989,-0.029411007,-0.067385435,0.051117353,0.027059037,-0.03378023,0.013045135,-0.03527857,-0.06988006,0.0421539,-0.100496545,0.0015295888,0.027140066,0.0034602743,0.028770365,-0.038238373,0.10503706,0.090210006,-0.0074379114,-0.027296621,0.045849018,-0.05738513,0.008355819,-0.022727212,0.015768318,-0.045673586,-0.05059878,-0.042367525,0.029628903,-0.040645175,0.086888015,0.13544248,0.021081613,-0.010425926,0.034184236,0.03498879,0.03526522,-0.011891663,0.043094657,-0.062443066,-0.028779892,-0.01321016,0.011574804,0.057380933,0.03132685,-0.010103909,-0.06656654,-0.062201586,-0.06460285,-0.0322413,0.06356146,0.0570768,-0.06331884,0.02094229,-0.0019659917,0.044666473,0.021402465,0.05382674,-0.0009026023,0.04255761,-0.009630847,-0.082061425,0.10690001,-0.103930086,-0.008843595,-0.05492265,-0.018596066,-0.033238567,0.01493911,-0.086941995,-0.039771717,0.025213396,-0.04929903,0.0118337395,0.048738036,-0.066213846,0.0605325,0.046832576,0.036142655,0.026024718,-0.008637936,-0.020240927,-0.00082320534,0.03828683,0.039384615,-0.04614247,-0.011390196,-0.04106108,-0.00029067456,-0.04319265,-0.07205317,-0.025066929,0.085654825,0.06188629,0.02584465,0.0414515,-0.013717309,0.013358052,0.014497801,-0.04521755,-0.087071866,-0.014303611,0.015416135,0.07832185,0.048705213,0.052366707,0.035819698,0.083724275,0.035458766,0.038117062,-0.056555245,0.018044632,-0.017617276,-0.10685301,-0.017424662,0.01163159,0.037627902,-0.06642161,0.07401167,0.019783478,-0.0028477951,0.055652786,0.023710938,1.9083095e-33,0.109352134,0.030491875,0.045610517,-0.048820175,0.02097349,0.011250393,-0.042970344,-0.008586094,-0.0663744,-0.009389897,-0.03414158,0.016198492,0.06115014,0.094253324,-0.013046649,0.06347414,0.021329774,-0.0072525935,0.06358143,-0.0145553555,0.042613015,0.045595817,-0.053744502,0.039478093,0.007524584,0.04296805,-0.039817125,0.012986347,-0.014275403,0.0020039175,0.033263743,-0.11259254,-0.07524898,0.046675157,0.014974439,0.023624677,-0.050782867,-0.08226674,0.033764903,-0.044286415,0.032589536,0.04575408,-0.0020297014,-0.056600608,0.036673296,0.039642774,-0.04764296,0.009907292,-0.024096372,0.093202755,-0.011565159,-0.034337714,0.06029437,0.012856374,-0.07453867,0.058089774,-0.03446492,-0.028204115,0.04956499,0.09142724,-0.041554578,0.03985908,-0.03822883,-0.010205347,0.01678699,0.006130629,-0.0606824,-0.047050454,0.03967841,0.08154572,-0.042537738,-0.032115936,-0.006582228,0.10408699,-0.040754806,-0.09267109,0.02946632,0.0346581,0.016341299,-0.016255293,0.026596434,0.0017645443,0.017146872,-0.08767361,-0.057483573,0.033776686,-0.029853627,-0.06632598,-0.034263782,0.048010923,-0.0048996205,-0.06400493,-0.040326666,0.06528989,0.0042663617,-4.5309687e-33,0.10853369,-0.06801993,0.066979684,-0.07019722,-0.08201736,0.04286383,-0.005037339,-0.017393092,0.0063635972,-0.06325059,0.05398131,0.022248914,0.05760092,-0.0009933747,0.05625113,-0.044346303,-0.011380833,0.10471954,0.029698178,0.031076046,0.060545165,0.039917227,-0.052577615,-0.053732026,0.057913665,-0.043952685,-0.01272436,0.059428703,-0.032909382,0.08053934,-0.0010069582,0.03954052,-0.09152736,-0.04508171,-0.06474351,0.009218043,-0.081380405,-0.005959757,-0.0025197389,0.009681602,0.02860175,0.08078977,0.049539637,-0.006327731,0.032399505,0.102090195,-0.103972554,-0.033007715,-0.018725798,-0.08133857,-0.0028320085,0.01454375,-0.03206793,-0.036551584,-0.02310738,0.07736949,0.061803285,0.023378158,-0.02834806,-0.086438455,-0.044241693,-0.08239402,0.029458266,-0.0016876129,0.053327702,0.055521794,0.0076696775,0.007515008,0.056557864,-0.007751166,-0.02500929,0.007670356,0.03334116,0.016403167,-0.07404137,-0.05240126,-0.13282481,-0.033646706,0.00835352,-0.07336171,0.08061882,-0.010859639,0.037336662,-0.054954115,-0.018691683,-0.06622712,0.09666567,0.08609105,0.02585327,0.074028656,-0.041423015,-0.017925246,-0.06666018,-0.008070328,0.03679601,-4.4799823e-08,0.06814242,0.01229575,0.044858884,-0.051539037,-0.049133264,0.0007612719,0.025531944,0.042788446,0.06168747,-0.031369913,-0.008957628,0.10149044,-0.0076758093,-0.031814765,-0.015735297,0.08828432,-0.105558716,-0.041026104,-0.020823466,0.07481547,-0.05975006,-0.015509258,-0.032397233,0.07369049,0.004986142,-0.05361024,0.07210747,0.08020724,-0.020061422,-0.07003508,-0.034450352,0.025524497,-0.0024430286,-0.00091420015,-0.07251537,-0.058184292,-0.041165296,-0.012564864,-0.007066044,-0.019918647,0.0147343,-0.04613956,-0.0529922,0.02817078,-0.0061915983,0.01290697,-0.01019299,0.019176506,-0.046157993,0.037709348,0.02355704,-0.007166163,-0.037763633,-0.11520828,-0.090699494,-0.042652216,-0.009246663,-0.0024602623,-0.058048245,0.012785189,0.05506688,-0.02194945,0.18855281,-0.046770938 +2.4.1.154,The enzyme is highly acceptor-specific; it does not act on globotetraosylceramide or lactosylceramide. The product has a terminal beta-N-acetylgalactosamine residue.,384,0.99999994,0.01117929,-0.12187529,-0.0795518,-0.03374714,0.011206923,-0.030574098,0.04029549,0.07049304,-0.018230854,-0.00985849,0.05607911,0.02280399,-0.079949096,0.07805981,-0.09047382,0.046444524,0.039245497,-0.03110599,0.038874213,0.008710883,0.059346873,0.021764528,0.012453583,-0.006972202,0.0154431565,-0.013323021,0.047782935,-0.083189435,-0.0028396402,-0.08429256,-0.04333572,-0.045749884,0.05659525,0.015287534,0.07174319,0.05957201,-0.08145438,-0.014244187,0.0026793287,-0.006399744,0.056776043,-0.03631815,-0.013547917,0.01019578,-0.025156155,-0.074779704,-0.009110415,0.047931418,0.01827387,0.05724791,-0.024632074,-0.13548693,-0.00025637535,0.05272635,-0.06286328,0.012328707,-0.08958049,-0.016908031,0.027272778,0.030162927,-0.019226477,0.0073866984,-0.027557317,0.0024714754,0.054413673,-0.032476988,0.0729998,-0.114554584,-0.097515084,-0.0024395012,0.068164945,-0.08781252,0.037721857,0.0015594512,0.02470021,0.05138891,-0.046028778,0.014466471,0.10379865,0.042491,0.015539844,-0.05459253,0.073523015,0.064631894,0.023114048,0.030664466,-0.013758281,0.05937531,0.09847292,0.03492175,-0.01731913,-0.051029712,0.039787836,-0.064107135,-0.063060306,-0.07238649,0.0011639203,0.021156166,0.023213817,-0.02622238,-0.0140676545,0.046524365,-0.04039068,-0.020846477,-0.10172002,0.075326495,0.022693727,0.017414698,0.038872886,-0.04513857,-0.086336896,0.05698582,0.096935384,0.04767068,-0.06864708,0.07719483,0.05028701,-0.092581004,-0.03954965,-0.005779386,-0.0027445306,-0.0141441,0.0674025,0.023669738,-0.02301353,0.07957019,-0.03829175,1.4585419e-33,0.017392874,-0.01862342,0.04630335,-0.084760524,-0.009565185,0.034362163,-0.05864707,-0.04803813,-0.05019943,-0.031639904,-0.03728838,-0.05980977,0.05252936,0.12040599,0.036712453,0.09430724,0.047018178,0.0012373851,0.09304708,-0.012166252,0.035091482,0.043583192,-0.09736993,0.032439318,-0.028337922,0.05534542,-0.0705303,0.096804224,0.037098885,0.020042375,0.030911434,-0.06767551,-0.047697157,0.07943793,-0.02910151,0.06581001,-0.020502327,-0.05029038,-0.0038543376,-0.023583177,-0.01734144,0.04154773,-0.017583152,-0.009380588,0.030827373,-0.06286811,-0.004098028,-0.013252733,-0.009821095,0.08149685,0.03662307,-0.011884702,-0.00024213934,-0.021127872,0.0005427489,0.10633478,-0.028179357,0.025022736,0.06266351,0.025045346,0.0406398,0.025838755,0.007508472,-0.055830803,-0.02910292,0.04514831,-0.03592585,-0.06800801,-0.06610965,0.05036605,-0.058849018,-0.028710462,0.028265487,0.077630185,0.012303066,-0.076548785,0.02480294,0.013651415,0.009740473,-0.04486751,-0.026986094,-0.08741024,0.010265171,-0.007729609,-0.059144493,0.028722726,0.011810507,-0.060764134,-0.058959983,0.029233707,0.06445349,-0.05652129,-0.10362804,0.08438926,0.022071477,-2.7885962e-33,0.08246843,-0.091538034,0.0894139,-0.042976476,-0.0475926,0.059522834,0.031902697,-0.029449485,0.079703934,-0.04749784,0.025733342,0.023791414,-0.01307079,-0.0060010045,0.005949886,0.025013734,-0.030639926,2.0449825e-05,-0.013998793,-0.012408252,-0.007994775,0.08322008,0.010902571,-0.014303327,0.022487935,0.009303589,-0.05005828,0.045615017,0.035544373,0.021291973,-0.047397044,0.078705914,-0.020788176,-0.11229756,-0.025257783,-0.00055764813,-0.04350542,-0.024910267,0.0035810887,-0.03823394,-0.007045001,0.04557174,-0.059351683,0.044414986,0.018270018,0.078426406,-0.00871284,-0.041531887,0.025950355,-0.06909957,-0.0036203766,0.048818223,0.038356792,0.054899603,0.083439596,0.107866496,0.044138256,-0.04967715,-0.06305153,-0.023610262,0.011677011,0.027795691,-0.025224987,-0.064543955,0.09024745,0.01555602,-0.030761737,0.050960403,0.040832277,-0.008069314,0.027004883,-0.023471722,0.0105348965,0.10360912,-0.009856402,-0.019141102,-0.091718495,-0.08081786,0.0062403814,-0.05871937,0.0078324685,0.05624528,0.012332115,0.024638543,0.038186044,-0.028571079,-0.024350375,0.062437322,0.0011386324,0.057468235,-0.023255752,-0.021968458,-0.019392407,0.040230393,0.06864421,-3.7047617e-08,0.006255762,-0.0150653925,-0.018192064,-0.1206164,-0.04442869,0.0022192912,-0.04624446,-0.045224812,0.0032710773,-0.0226958,-0.053334963,0.12990955,-0.020162657,0.023776345,-0.001842213,-0.005063356,-0.015415324,-0.057336517,-0.036373936,0.0010878686,-0.108079754,0.0014444938,-0.033418886,0.008137184,-0.043967314,-0.040452473,0.035792388,0.102825105,-0.0821677,0.02895614,-0.049100615,0.058162563,0.012549528,-0.06330423,-0.014221422,0.051590845,-0.012335927,-0.051417973,0.038709953,0.03904649,0.094887346,-0.048027225,-0.0048462865,0.0003758533,-0.03938531,0.03134196,0.032123666,-0.08439627,-0.0048646564,0.021803316,0.03099322,-0.03527424,-0.085661374,-0.0041892007,-0.021048866,-0.05742162,-0.01321664,-0.07984069,0.045360934,-0.09281993,0.05493691,-0.037517842,0.1568847,-0.07419974 +2.4.1.155,"Requires Mg2+. The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. It catalyses the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides, and thus enables the synthesis of tri- and tetra-antennary complexes.",384,1.0,-0.05600707,-0.051557265,-0.05225731,0.0114893345,-0.034601685,-0.030233243,0.021728285,-0.035934463,-0.029361289,0.06213312,0.047486383,0.03395453,-0.0096935835,0.0050171493,-0.04023038,-0.047381107,0.02758457,-0.01910158,0.017876796,-0.04209802,0.049448956,-0.0041103354,0.017300336,-0.026978113,-0.018535692,0.00032476327,0.014655872,-0.0791987,0.064450175,-0.046413805,-0.002913064,0.005863151,0.0040774685,-0.073787116,0.010213125,0.049513225,-0.005489971,0.01973104,-0.011836581,-0.04304101,0.024512136,-0.061651856,0.050003603,-0.01319901,-0.050625537,-0.120745815,0.0036825335,-0.0412306,0.047671873,0.015999118,-0.028429987,-0.0120322965,-0.08068245,0.018882854,0.07394047,0.07663086,-0.13843554,0.01908969,0.031224474,0.0703417,0.09906281,0.007526207,-0.030971369,-0.05558338,0.035390284,-0.04653098,0.035569273,-0.056645095,-0.016838275,0.061096445,0.010701753,-0.012356395,-0.038516328,-0.053980365,-0.03070788,0.042775635,-0.0072155898,-0.015619729,0.045384575,0.05394207,-0.036089387,0.02338282,0.072006755,0.096163906,-0.008008268,0.0023165673,-0.019111235,0.08292908,-0.00066218316,0.0026440776,0.060784705,0.018011637,0.010175368,0.024606796,-0.057968125,0.019095572,-0.03148109,0.028062936,0.059059918,-0.0010507808,0.010147269,0.019099208,0.061670706,-0.0432119,-0.10505197,0.05879762,-0.048638213,0.06198627,0.08017185,0.02681978,-0.006385311,0.053757735,0.055217735,0.05333534,-0.11444625,0.09607832,-0.03241902,-0.1191864,0.038819883,-0.062436275,0.06615759,0.04593175,-0.003433324,0.087609634,-0.01713442,0.030584553,-0.035278622,1.6237537e-33,0.037469856,0.066401675,0.048334207,0.031430237,-0.0127391955,0.0073119504,-0.06202107,-0.056117523,-0.045125473,0.017896922,-0.064504914,0.017708417,-0.0029184665,0.13985676,0.00239964,0.0519414,-0.05477649,-0.030572018,0.09769594,-0.007665717,-0.046093535,0.06611367,-0.01645645,-0.011796654,0.07636885,0.136145,-0.021663893,-0.06998701,0.031751566,0.004450601,0.09967523,-0.09881474,-0.04625941,0.058634393,0.06611999,-0.0020414903,-2.2388216e-05,-0.052227262,0.001544622,0.020669479,0.0037378573,0.008502603,-0.030175379,0.06501383,0.05986936,-0.036825366,-0.0051072733,0.026206926,-0.027616398,0.09732672,0.051280312,-0.029426254,-0.020593261,0.07262613,-0.07722773,0.099498786,-0.068530984,-0.007175736,0.039296057,0.041309778,0.0025499996,-0.026816038,0.038043417,0.034404065,0.06433302,0.038196117,-0.058172934,-0.06355535,-0.0024695694,-0.003828608,-0.03493388,-0.02251709,0.059355907,0.0010627406,-0.0096105905,-0.04351032,-0.036491346,0.010149714,0.0149976285,0.037950728,0.025378285,-0.01091277,0.012140649,-0.03960075,-0.056875255,0.019950021,-0.015729016,-0.108985886,0.0087741995,0.038795665,0.011316229,0.019228965,-0.086792745,0.04809846,-0.010248704,-3.3509068e-33,0.10121951,-0.09674953,0.049489193,-0.05837486,-0.12684704,0.004454009,0.058005303,-0.14581783,0.02149771,-0.0067582186,0.07031697,0.01981286,0.006218459,-0.059983235,0.010728838,-0.0779735,-0.0013242187,0.083380744,-0.0016732318,-0.060392242,-0.025582645,0.082920596,0.0069901706,0.010585785,0.024644693,-0.002258616,0.02478127,0.0060077943,0.025473448,0.095088966,-0.008918444,0.016590688,-0.03051573,-0.061824597,0.046194695,0.063092045,-0.0024342986,0.035826307,-0.012294897,-0.015030176,0.017949557,0.066472314,0.07359288,-0.015279207,-0.004037457,0.06431173,-0.06866469,0.058751,-0.088017374,-0.03807029,0.042487986,-0.026520414,-0.042104583,-0.050292358,0.07715937,0.04208393,0.04153895,-0.05030032,0.0113206785,-0.034982253,-0.014290239,-0.034339607,0.041053884,-0.08553157,0.049825847,0.06891359,-0.023153014,0.018954577,0.047747545,0.08113546,-0.0041617714,-0.0050421352,-0.001881041,-0.0010700746,-0.023617256,0.06240562,-0.07689867,-0.051484097,-0.02221374,-0.08262282,0.016063724,0.04772828,0.005331366,-0.08376348,0.06814492,-0.07263289,0.021576183,0.1763723,0.028609596,0.021440731,-0.032464657,-0.076996855,-0.08113684,0.031528033,0.019081235,-4.0039954e-08,-0.03354407,-0.018985989,-0.079165414,-0.107801855,-0.024573747,0.039988745,0.0025461449,-0.016818626,0.02275738,-0.029433323,0.012485167,-0.017382575,-0.016717136,0.040120944,-0.0037488171,0.058365494,-0.021311527,-0.038680833,-0.03723982,-0.09205083,-0.11320086,-0.030391788,-0.10438707,0.07822142,-0.05458338,-0.052596457,0.08902157,0.07263045,-0.020855771,0.0001744385,-0.0041561113,0.028550852,-0.03949091,-0.013166603,-0.026435811,0.017806463,-0.007915765,-0.021011818,0.023942014,-0.07842687,-0.05373687,0.039321132,0.028689547,-0.048676107,-0.031168452,-0.022879915,0.046479464,0.017110607,-0.038855463,0.08567221,-0.028186085,-0.0086798305,-0.04287894,-0.112944216,-0.09317897,-0.034629818,0.005352599,-0.010191144,-0.012201557,-0.042593483,-0.026175903,0.014268435,0.06409987,-0.08538902 +2.4.1.157,"The enzyme from the bacterium Acholeplasma laidlawii, which lacks a celll wall, produces the major non-bilayer lipid in the organism. The enzyme from the bacterium Agrobacterium tumefaciens acts under phosphate deprivation, generating glycolipids as surrogates for phospholipids. The enzyme belongs to the GT4 family of configuration-retaining glycosyltransferases. Many diacylglycerols with long-chain acyl groups can act as acceptors. cf. EC 2.4.1.336, monoglucosyldiacylglycerol synthase.",384,0.99999994,-0.1175,-0.02216893,-0.121892855,0.03321626,-0.08656282,0.009612093,-0.09733677,0.021619905,0.038135882,-0.032727856,0.021492269,-0.041193344,-0.061185826,-0.014878955,-0.028034113,0.043644596,-0.05005531,-0.005966774,-0.067254074,-0.11160654,0.055138677,0.050744366,-0.027578926,-0.022235002,-0.008336641,-0.0770884,0.016424602,-0.06080517,-0.016577976,-0.06175649,-0.02248126,-0.05760982,0.043356273,-0.047599323,0.11507754,0.046321433,-0.016397726,0.04697379,0.074834295,0.002975004,0.04575189,-0.0352941,-0.0012917889,0.018116217,-0.0144644845,-0.012459041,-0.020284273,0.0663882,0.08085699,0.023666859,-0.05652939,-0.02056361,-0.05628747,0.023925439,-0.012923447,0.03553864,-0.06964809,-0.043082677,-0.02044546,0.044182133,0.06306536,-0.038689982,0.021857942,0.040353663,-0.08364189,-0.09774283,0.068701476,-0.07607796,0.027158894,0.038128696,-0.043201573,-0.04098295,-0.017352043,0.008374931,0.012127895,0.043386143,-0.024876004,-0.03145589,0.067009166,-0.033300202,0.06249221,-0.006960712,0.016379707,0.072592035,-0.02693026,-0.09736685,0.053176224,-0.007312355,0.008893023,0.04877562,-0.01192666,-0.025780786,0.039026488,-0.01659358,-0.013204485,-0.021195903,0.059879962,-0.06435783,0.02488188,-0.04089694,0.005443541,-0.0042440123,0.040036302,-0.027406424,-0.06239367,0.009895555,-0.003871791,0.032736458,-0.00031204062,0.047184907,0.031968985,0.028754085,0.09514891,0.00058258686,-0.04413478,-0.0035727771,-0.02655308,-0.06844021,-0.037537012,0.0024889698,-0.07038369,-0.033483896,0.04552428,-0.0014275061,0.00024718375,0.0938631,-0.080912545,4.2089e-33,0.0882498,0.040952656,-0.021141175,-0.04121479,-0.0047503198,-0.029217865,-0.06933583,-0.0028507446,-0.09882977,0.025037803,-0.035173748,-0.09893407,0.005921566,0.11627734,-0.018677127,0.04659318,0.052018464,0.023058893,0.067935996,0.020461263,-0.04332119,0.042315703,0.037991814,-0.029604806,0.07334201,0.09305626,-0.01835093,-0.043268982,0.016434385,0.0239475,0.040373947,-0.09617087,-0.027463492,-0.017777612,0.10063153,0.06432189,0.008901372,-0.024966726,-0.02382518,0.0258029,-0.025473967,0.024396341,0.0036188846,-0.053798217,0.019830624,-0.040151,-0.098738745,0.055768073,0.03812319,0.055242237,-0.019098356,0.032966424,0.07942831,0.06150734,-0.002562618,-0.03457702,-0.05420016,0.04580851,0.025122408,-0.0032045527,0.012681758,0.1602766,-0.08709521,0.018439677,-0.024375759,0.024460735,-0.085589565,-0.045729674,-0.050645992,0.05598674,0.048064917,-0.009174958,0.005876681,0.07522051,0.049140293,-0.06834037,0.006283375,0.035201106,-0.012115577,-0.015134875,0.006644445,0.04351427,0.055656742,-0.08564202,-0.07448857,-0.045753438,-0.04610588,-0.019179232,0.01590117,0.014145132,-0.0511346,-0.03091303,-0.038296375,0.06910442,-0.018884858,-5.0308253e-33,0.067487866,-0.052638873,0.07657727,-0.07057804,-0.0063378084,0.0710321,-0.012975863,0.033804268,0.055695754,0.031344756,0.048608296,0.09750978,0.06419385,-0.02138608,0.043147452,-0.011889761,-0.015846293,0.0025315436,-0.05157738,-0.056582168,-0.00822411,0.047659967,-0.005585179,0.08085403,0.035433494,0.009467855,-0.06872097,0.05040985,-0.07093204,0.056371436,-0.0029363576,0.017403439,-0.08637935,-0.07849896,-0.08151839,-0.0048457994,-0.07531554,0.016728291,-0.053495705,0.035905994,0.0007682886,0.06242951,0.048625734,0.043302402,0.055629585,0.024439815,-0.020079983,0.036459066,-0.016534736,-0.05895576,-0.01527634,0.038410395,0.029956346,0.06384117,0.085486226,0.09499791,0.028979389,0.036210783,-0.044685107,-0.088183776,-0.034672108,-0.1432529,0.062265523,-0.016893448,0.0968913,0.10950719,0.010229259,0.029890977,-0.012165808,0.02542642,0.0006794748,0.051818106,-0.048390128,0.016590934,0.03387745,0.08492324,-0.081383705,-0.07025234,-0.009186027,0.020454343,0.026693165,-0.010710503,0.060873084,-0.07343637,0.07185066,-0.030255854,-0.008695792,0.04233007,-0.030253995,0.08785112,-0.007469094,-0.048665695,-0.049239907,0.010052453,0.045040756,-4.0869818e-08,0.07010937,-0.016874949,0.039242677,-0.09201137,-0.0693924,0.0005565898,0.02653518,-0.002385247,0.06869209,-0.063236155,-0.08288817,0.06698337,0.01658551,0.0058689397,0.034867164,0.058836974,-0.047919676,0.03168123,-0.030753454,-0.022900604,-0.047553685,-0.01704309,-0.12206451,0.11660455,-0.021443121,-0.058791872,0.06804113,-0.048034903,-0.058446445,0.04279591,-0.014653148,0.0303091,-0.019563112,-0.0075446456,-0.017931748,-0.025057241,0.02570811,-0.035713337,-0.049680512,0.070875265,0.010596034,-0.0139707355,-0.040555254,0.00015405614,-0.021225266,-0.0013334684,-0.0078872135,0.019833118,-0.064628795,0.034663178,-0.037050404,-0.0013169604,-0.025105033,-0.02027371,-0.029384851,-0.039537203,0.014541916,-0.043413054,-0.021705119,-0.00030085738,-0.027805982,0.019818857,0.20131886,-0.023525268 +2.4.1.158,"13-beta-D-Glucosyloxydocosanoate can also act as acceptor, leading to the formation by Candida bogoriensis of the extracellular glycolipid, hydroxydocosanoate sophoroside diacetate.",384,1.0,-0.02191833,-0.03842681,-0.09225491,-0.01889105,-0.059329968,0.010791078,-0.037541423,-0.025710983,0.0050235675,-0.04126854,0.06872941,0.0463104,-0.097219,0.005112169,-0.07807996,-0.047590774,-0.0037466595,0.055754077,-0.056616608,0.06407349,0.055613272,0.0047311564,0.07771361,0.028671674,0.07330255,0.0013585946,0.027787069,-0.01359785,0.020114299,-0.1215464,-0.03464523,0.076594815,0.056360826,-0.013011647,0.0052548274,0.028671656,0.008799311,0.023010107,0.124357164,-0.008779015,-0.026706474,-0.083711475,0.042727783,0.009020716,-0.05241431,-0.014287153,-0.017094716,0.0793412,0.11726041,0.008642786,0.031567313,0.015556113,-0.040462703,0.0011218095,0.026302196,0.017818267,-0.039425638,-0.0014954072,0.024074769,0.020747388,0.071594074,0.0029415796,0.05342948,0.059037413,-0.07423406,-0.10841855,-0.009656944,-0.027399696,-0.025953444,-0.037221063,0.005922502,-0.023812084,-0.0082456,0.011315299,0.045219418,0.11093527,-0.016182596,-0.034777276,0.07052959,0.036675025,0.11366761,0.035120584,0.094861224,0.037000787,-0.04523458,-0.10508549,0.04064142,0.114533566,-0.036091298,0.03535765,0.0030677468,-0.0067660324,0.013209035,-0.004880536,-0.028904745,-0.02133148,0.07281322,-0.012336692,-0.009080164,-0.00086124206,-0.06572944,-0.048055008,0.06027683,-0.020950837,0.042508204,0.040776607,-0.012966096,-0.027525537,0.08615535,0.009889548,-0.008968234,0.00051045726,-0.013385487,-0.012071299,-0.047636837,-0.00095284183,0.03151626,-0.025164612,-0.085452944,-0.13636072,-0.023118913,-0.04574074,0.039785374,-0.041800596,-0.06906969,0.008240527,0.02140448,3.4552474e-33,0.09018015,0.038789567,0.019316128,-0.05449904,-0.00036327104,-0.039917033,-0.019665841,-0.019535528,-0.0577618,-0.043280367,-0.06886868,0.007701026,0.002393901,0.1491157,-0.053409524,0.102672935,-0.024025181,-0.0151849035,0.045392573,-0.060495757,0.01145351,0.018545356,-0.024271432,-0.097575314,0.07035091,0.01897417,-0.006126592,0.090240255,0.08445435,-0.02430231,0.088447355,-0.1417609,-0.0147377085,0.031146375,0.0699318,0.0087649645,0.00873262,-0.07049448,0.01062384,-0.07408071,-0.013727793,-0.018967105,-0.057730608,-0.03250674,0.01402696,0.03111633,0.010365979,-0.0054752002,-0.0041132914,0.096062414,-0.0052067153,-0.007997938,-0.016485602,0.06740286,-0.021644888,0.0019196654,-0.03498068,0.008602914,0.013614477,0.04530882,-0.017291112,0.03722622,0.024170516,0.011994362,0.028737443,-0.005930683,-0.08967046,0.015980419,-0.059322115,-0.03136622,-0.0097359875,-0.07129844,-0.035773925,-0.023605095,-0.03298147,-0.06671958,0.047338843,-0.045239445,-0.023208214,-0.023718717,0.0011911431,-0.009932933,-0.018290156,-0.026185652,-0.10041508,0.10891992,-0.037315916,-0.08125046,-0.016960606,0.0063739996,-0.0782984,-0.032672342,-0.045023438,0.05319265,0.07042013,-5.656302e-33,0.104542516,-0.10128939,0.04377323,-0.05616266,0.011826594,0.039011937,0.06139792,-0.02745877,-0.021634797,-0.035684586,-0.020392008,0.0053890706,0.027851965,-0.003861857,-0.004804471,-0.08107669,0.020128002,0.07333921,-0.046550598,0.021975582,0.012264002,0.094828784,-0.073036596,0.050095983,0.034831256,-0.011896433,0.042365495,0.017233435,-0.08933509,0.082918,0.034557533,0.048491575,-0.022991676,-0.052185047,0.009219302,0.04878462,-0.047478028,-0.022253023,-0.06599391,-0.026110347,-0.067315675,-0.03970127,-0.08295201,0.0569773,0.13511725,0.05434758,-0.028393768,0.06612234,0.08367307,0.019676201,-0.014587511,0.061177075,0.003593442,0.09481225,0.06508445,0.04048713,0.04090532,0.010737369,0.032754257,-0.05479627,-0.060542367,-0.09102647,0.041125856,-0.08942279,0.07994475,0.044991244,-0.087747574,0.0051221964,0.07690566,-0.020431835,0.008168768,0.01278423,-0.049199875,0.077070355,-0.004692214,-0.026202098,-0.05204015,-0.10592585,0.014340777,0.050507072,-0.021151688,0.029159524,0.052207444,0.00043512747,0.010402247,-0.055991597,0.053589154,0.033325497,-0.11887388,0.07352556,0.014742796,0.017090015,-0.09394646,0.05454902,-0.015881643,-3.5003502e-08,0.06530051,0.025273094,0.08100526,-0.072272256,-0.024150077,0.03922265,0.054016765,-0.011611502,0.012023568,-0.06659498,-0.03562209,0.0785246,0.01504477,-0.020125581,0.01934489,-0.031957574,-0.103902385,0.026797025,-0.064470515,0.0054623266,-0.04448391,-0.049085304,-0.053312104,0.06033497,-0.01857614,-0.049784973,0.04001914,0.039765615,0.022882253,0.00706038,0.057210643,0.020733424,0.000112288144,-0.036911696,0.020310583,0.0106719285,-0.026645772,0.018290726,0.02737481,-0.053474072,-0.028705169,-0.010430179,0.010639251,-0.019946957,-0.07365444,0.0038562804,0.0025066093,0.037423804,-0.014309215,0.011426233,0.019703995,-0.027904194,-0.028290547,-0.027327608,-0.070031576,0.024675632,-0.038679097,0.012245365,-0.0285316,-0.01139312,-0.040343434,-0.07837111,0.13629939,-0.026457125 +2.4.1.159,"A configuration-inverting rhamnosyltransferase that converts flavonol 3-O-glucosides to 3-O-rutinosides. Also acts, more slowly, on rutin, quercetin 3-O-galactoside and flavonol 3-O-rhamnosides.",384,1.0,-0.051855713,-0.11016441,-0.14512624,0.061460547,0.03374234,-0.0012946961,-0.011846756,0.018495273,0.03972212,-0.0794735,-0.020727107,0.044392273,-0.0899071,-0.026373299,-0.034454998,0.0030228968,-0.031151423,0.15340903,-0.072676815,0.015734654,0.072765835,-0.058323216,0.08352562,0.03336056,0.041760348,-0.016809601,0.012999099,-0.05635457,0.025831955,-0.09601884,0.08045575,-0.025987072,0.08428639,-0.07001952,-0.04695215,0.047305815,0.003047938,-0.047721967,-0.014867353,0.06574535,0.0011613684,-0.009280333,0.042624652,-0.0089999,0.034165602,-0.07035021,-0.12726456,0.042231493,0.04388485,-0.030965172,-0.010987979,-0.04163645,-0.12703125,0.055469688,0.04692582,0.026914105,-0.092812866,-0.022468995,-0.008723936,0.04000802,0.09315727,-0.010272924,0.004500449,-0.020508934,-0.053005803,-0.015841626,0.030518515,-0.0127930585,0.0021447511,0.045346536,-0.051327962,-0.021356856,-0.07606412,-0.011365116,0.053255253,0.05318156,-0.04146028,0.07394829,-0.058486275,-0.01463234,0.11214472,-0.005458492,-0.01555609,0.078406505,0.007739893,-0.017628903,-0.05420353,-0.004529791,0.017777484,0.04653827,-0.042339146,-0.04146442,0.020897623,-0.0063080336,-0.044544555,0.010329661,0.065114915,-0.024511892,0.04393395,-0.0020312588,-0.018706953,0.0052132155,0.03912903,-0.030023009,-0.09116096,0.031062052,-0.0914644,0.041916676,0.017670326,-0.031952444,0.007890707,-0.0105064465,-0.010051407,-0.10449421,-0.1206866,0.035240356,-0.0081579685,-0.045374136,-0.071900584,0.026895866,-0.018827835,0.06929098,0.0112608755,0.0020877467,0.0057592914,-0.016135627,0.018257532,4.4427827e-33,0.03692985,0.057634074,-0.040107213,0.012819218,-0.055576373,0.025049787,-0.06340672,-0.056324862,0.010566804,-0.012805396,-0.046646047,0.0056281704,0.010938387,0.028943354,0.036276434,0.03399908,0.04096953,-0.046020944,0.03408011,-0.018189091,0.034063295,0.030137552,-0.10415315,-0.019795159,0.0012491671,0.014107596,0.030086273,0.0013585495,0.010795499,-0.037571583,0.028849408,-0.050760984,-0.03373632,0.051996868,-0.0145821385,0.066818856,-0.060937267,-0.14862646,0.023944879,0.060067307,-0.03878338,-0.017817548,-0.048499905,0.018952902,0.059525754,0.025902033,0.027627353,0.02448445,0.073740326,0.092424065,0.0075366898,0.003294833,0.04292794,0.09394467,-0.02939674,-0.031191066,-0.03703378,0.0055415505,0.082649365,0.057387147,0.013695195,-0.05002271,0.010184965,-0.05602199,-0.042181823,0.019143144,-0.03735386,-0.044897784,-0.019937316,0.0051443824,-0.022880642,-0.037811674,0.033500243,0.037370704,0.022588942,0.013695381,-0.042690665,0.02431158,0.009385553,-0.01540032,-0.03785333,0.061135415,0.038945004,0.04989327,-0.043322947,-0.01602778,0.0074002473,-0.040856704,0.0055047492,0.03215923,-0.039179187,-0.07541545,-0.047291037,0.05137968,0.034867838,-2.912573e-33,0.092386186,-0.097668715,0.0038771415,0.01770464,0.010673567,-0.0116783725,0.0033087179,-0.018970847,-0.017277116,-0.004331808,0.051477674,-0.040958848,0.03597314,-0.04020179,0.017511494,-0.067696914,0.07224218,0.071135625,-0.013933113,0.020306593,-0.013834954,0.06563286,-0.0022031325,0.09379107,-0.021120995,0.016570363,0.05313734,-0.03783568,-0.028557098,0.08723873,-0.0075885314,-0.020720178,-0.031436063,-0.016505683,-0.008633557,0.11608976,0.07694945,0.07337716,-0.09438446,0.028646281,0.014330689,0.05500404,0.023392359,0.022233386,0.074669875,0.081877306,-0.07699536,0.06040548,-0.006570612,-0.011369193,0.05475785,0.05585117,-0.008685288,0.06108707,0.07744095,-0.03888324,0.030381162,-0.05962218,0.050031684,-0.0007325141,-0.07396407,-0.0959408,0.064867646,-0.034549516,0.022065124,0.097685814,0.038414862,0.05486465,0.048697356,0.03097953,0.019669347,-0.08600351,0.049227078,0.09930634,0.012739998,-0.079264864,-0.052103568,-0.057573855,-0.038943518,-0.024724659,0.0575343,-0.12176998,0.056671627,-0.0045172386,-0.002385945,-0.07723731,-0.008253054,0.028397672,0.03193138,-0.0009759394,0.0040339064,0.01178049,-0.05706243,0.03199193,0.09389803,-3.28242e-08,0.04304189,-0.027736451,0.053199124,0.055109337,0.033390895,-0.011842716,-0.008145308,0.005231996,-0.07899082,0.012974497,-0.014624157,0.090421595,0.0047576516,-0.045896232,0.059735607,0.04230382,0.040902518,0.07973471,0.010104887,-0.00918307,-0.05631873,0.06049533,-0.02589455,-0.06388667,0.07520517,-0.056326743,0.07753344,0.044691887,0.09991744,-0.02887865,0.11863335,0.0061330707,0.069470525,0.05177103,-0.118925184,-0.05013271,-0.01076441,0.059331033,-0.032201536,-0.020150648,-0.10321913,0.03869004,-0.013072458,0.038784027,-0.06985512,-0.018657453,-0.03892773,0.018172404,0.014066016,-0.017623553,0.05387416,-0.0784105,-0.007634573,-0.031297382,-0.08181147,-0.08238947,0.0032202664,0.0098812,0.008197105,-0.06779329,-0.055692602,-0.017192338,0.09612775,0.02749187 +2.4.1.160,"4'-Deoxypyridoxine and pyridoxamine can also act as acceptors, but more slowly.",384,0.99999994,0.0271306,-0.08875257,-0.014921173,-0.011704397,0.046210684,-0.03236048,-0.013001301,0.048647184,0.029661525,-0.010298889,0.09577955,-0.019328143,-0.041766997,0.12927823,0.005232785,0.091021076,-0.033266556,0.04628222,-0.0005696963,0.08043995,-0.030528147,-0.028855508,0.016019927,0.006867604,-0.09055687,0.04373975,-0.011641113,0.05250385,-0.0006227214,-0.108207956,-0.029598005,0.02872954,-0.023816058,-0.0134493625,-0.01220009,0.034362406,-0.09150632,0.04185415,0.02073286,0.015207773,0.02899456,-0.04708888,0.033053897,0.029782673,-0.07102322,-0.029533884,0.060263924,-0.01667968,0.041135997,-0.096469276,0.0003176398,0.023883924,-0.0104152495,0.09240739,-0.041863322,0.007874484,-0.10700488,0.041278016,-0.0017114019,-0.0015783549,0.0001587165,-0.010059952,-0.02059383,-0.020294469,0.04631959,0.03407878,0.01627272,-0.046262342,-0.03849769,0.02112587,0.06787208,0.006528549,0.028159985,-0.035573892,0.069575906,0.04551427,-0.0659428,-0.023834558,0.025702406,0.051715635,-0.053223073,-0.008306138,0.060611952,0.041855223,0.045197867,0.026364772,-0.044755984,-0.0111854505,-0.07932604,0.041186642,0.023928577,-0.0038491262,0.03150027,-0.0042053573,0.020146543,-0.04298844,0.048995767,0.014689788,-0.008930894,-0.016633311,-0.031214446,0.01108468,-0.17786534,0.015159708,-0.008106291,-0.024018962,0.08315492,-0.03777003,-0.01006707,0.03609268,-0.046339963,-0.060496416,0.048437383,0.08837708,-0.060031336,0.029566046,0.029965796,-0.029897273,0.0031186384,-0.008902454,-0.012625981,0.043069262,0.024689082,-0.03859993,0.015163308,0.018905438,-0.06385601,3.8810577e-33,-0.015053498,0.0720549,0.02689903,0.011539239,0.0014152459,-0.008395517,-0.09392077,-0.053987272,-0.040522516,-0.000646714,-0.1414922,0.016068675,0.06868734,0.116157874,-0.03851894,-0.10731407,-0.027502775,0.029416239,0.05018941,-0.060569648,0.05795069,0.02258333,-0.026685225,0.06987969,-0.04005631,0.041505482,-0.051907323,0.06487449,0.018911134,-0.015150526,-0.013098773,-0.027273448,-0.05936521,0.026534004,0.0021290295,0.054620318,0.016293665,-0.019611508,-0.04540566,-0.043012805,-0.07270016,0.0046862816,-0.118032195,-0.0002533893,0.07657305,-0.044529,-0.085327946,-4.9980248e-05,-0.05872968,0.026586829,0.039107367,-0.01620178,0.005441638,-0.09611634,-0.022049516,-0.07058321,0.022525212,-0.042525098,-0.004871173,0.03473358,0.011434892,0.0522499,-0.0664966,-0.029962616,0.004753788,0.021695524,0.031183543,-0.09047841,-0.014898221,0.009052112,-0.036055807,-0.029071005,0.018116493,0.0269101,0.03059981,-0.05911762,-0.07142928,0.0019238555,0.046272386,-0.03048585,-0.03469934,-0.088022836,0.0018889493,0.053387463,-0.041726857,-0.046278395,0.027804423,-0.07955158,0.047503855,0.030345371,0.00867494,-0.08737106,-0.03895188,-0.031129954,0.023540882,-4.1201503e-33,0.04141325,-0.038687933,0.067363285,0.031554386,0.031810127,0.1284307,0.02860366,0.048760787,0.1324113,-0.028384075,0.102105446,0.018035606,-0.0018305386,0.0034243464,0.027555745,0.044183433,-0.027953377,0.006654259,0.055561833,-0.01154343,0.010111193,0.04441844,-0.08702032,0.037110966,0.052578792,0.08348343,0.04702528,-0.00025709136,0.0070753954,0.026574377,-0.10184872,0.016136456,-0.01933115,-0.03682734,0.002266105,0.07466523,-0.11520183,0.044693537,-0.07580231,-0.043424428,0.0001832394,0.0054192916,0.03318689,0.0903362,-0.017314177,-0.011445281,0.026407039,0.0063126995,-0.0048503135,0.039628576,0.02354877,0.058533855,-0.04518648,-0.031233788,0.097739,-0.0070221047,0.011963179,-0.120444775,0.011401721,-0.0052889925,-0.023056153,-0.04836873,0.03845957,0.03686995,0.05000091,0.036440745,-0.02918282,0.008433355,0.08708373,-0.007258369,0.12063304,0.0076850937,0.060519878,0.071815096,-0.0112665,-0.075988114,-0.04403138,-0.010543163,0.035444174,-0.018317953,-0.09853236,0.04127312,0.07688248,-0.10158778,0.03640608,-0.07330508,0.004783134,0.038559455,-0.010014119,0.05384936,0.08825081,0.009852324,0.06877483,0.02214058,0.05796905,-3.0565293e-08,0.06259971,-0.035244696,0.03918998,-0.036574446,-0.045120258,0.04725975,0.05685523,-0.009031497,-0.0053316876,-0.040057883,0.081905596,0.107005596,0.07732658,-0.02590493,0.08661213,0.02648084,-0.0534411,-0.028583774,-0.04578776,-0.043867648,-0.12627278,0.016082328,-0.04439628,-0.04870623,0.0047998684,0.011432692,-0.025532141,0.018894287,-0.0076554352,-0.0049869274,0.041991174,0.002909104,0.028823892,-0.10250987,-0.024488723,0.022316536,-0.015110157,-0.0404474,-0.048700374,0.016936338,-0.054347515,-0.10285962,-0.07132772,0.00029836918,-0.031353317,0.014562668,-0.04698639,-0.03494106,-0.013510325,-0.012864221,0.07522684,0.0054955166,0.03978974,-0.025587615,-0.10225046,0.10446762,-0.011391018,-0.025679417,-0.045664635,-0.1419292,-0.025401736,-0.009110208,0.13324334,-0.010967584 +2.4.1.161,"The enzyme acts on amylose, amylopectin, glycogen and maltooligosaccharides. No detectable free glucose is formed, indicating the enzyme does not act as a hydrolase. The enzyme from the bacterium Cellvibrio japonicus has the highest activity with maltotriose as a donor, and also accepts maltose [3], while the enzyme from amoeba does not accept maltose [1,2]. Oligosaccharides with 1->6 linkages cannot function as donors, but can act as acceptors [3]. Unlike EC 2.4.1.25, 4-alpha-glucanotransferase, this enzyme can transfer only a single glucosyl residue. 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+2.4.1.163,Requires Mn2+.,384,1.0,-0.036360487,-0.044458427,0.017822001,0.02654448,0.022565527,-0.07774763,-0.01671729,-0.0066741058,-0.08113136,0.008605609,0.037501145,-0.00853473,0.038291153,0.046258923,0.035204828,0.017164793,0.008483622,0.0010981181,0.022155419,0.043888234,0.09535097,-0.047738057,0.035636567,-0.10649236,0.080589876,0.038108997,0.021358317,-0.020172775,0.047707476,-0.022710444,0.001964823,0.07182767,0.03759382,-0.07103112,0.027451148,0.03208132,0.02418689,-0.031265844,-0.06567195,-0.0353328,-0.04206804,0.0073473584,0.111062475,-0.0032721923,0.010026853,-0.052635245,0.08713465,-0.06195826,0.032884475,0.050265517,-0.04517185,-0.010509251,-0.038998242,0.06577855,0.007258663,-0.013984565,-0.08798442,0.031221677,-0.020264747,0.020340305,-0.030886542,-0.06213404,-0.027272224,0.036563847,0.08422962,0.0193712,0.016521063,-0.05247887,-0.027940663,0.04684452,0.027259313,0.0340272,-0.06437856,0.02126383,-0.024103496,0.0154093485,0.071803205,-0.052876625,0.09380725,-0.0075167003,-0.11221875,-0.0030692108,0.02679672,-0.006094525,0.10713053,0.07699597,0.012755593,-0.016074155,-0.06754226,-0.0029608328,-0.0026667763,0.034529805,-0.0109483795,0.046426535,0.02924049,0.003930778,-0.03416443,0.031399682,-0.0929341,0.09565302,-0.01218027,0.035898115,-0.07906176,-0.0095144715,0.026446966,-0.07083552,0.06617603,0.040388364,-0.058188744,0.04259121,0.102053724,0.028116403,-0.0054726633,0.00010419161,0.023108644,0.028096316,0.024296738,-0.03508994,-0.00081681664,-0.0015044805,0.0229969,-0.01756427,-0.09027102,-0.007468594,-0.07151089,-0.034110405,0.0024530445,-2.1413545e-33,0.017724067,0.051661883,-0.021066902,0.043503698,-0.01049654,0.04684857,-0.049679115,-0.037014585,-0.004570793,-0.09597654,-0.09281623,-0.053237706,-0.020317584,0.0834843,0.04281833,-0.119611666,0.052882504,-0.017666025,0.14997219,-0.0137100015,0.020340055,0.0016038642,-0.02323011,-0.022663647,-0.013719981,0.07186442,0.13971443,-0.05194357,0.07355635,0.025671242,0.0034975566,-0.08866127,-0.06837138,0.0008731175,0.013852457,0.06542914,-0.11089267,-0.023947844,-0.010690566,-0.025923576,-0.023453522,0.08276505,-0.1598188,0.018604605,0.037131157,-0.077226475,0.0588696,0.04911015,-0.039315026,0.043499716,-0.028326973,0.057479832,-0.01836195,0.0353466,-0.021296928,0.016664,0.08537686,0.019563615,0.07890358,0.08904385,-0.05539112,-0.01854758,0.08613782,0.10673294,0.01158494,0.034094516,-0.04567807,-0.04347245,-0.030515159,0.024576593,0.012338733,-0.10936096,0.076678,0.050040204,-0.021210358,-0.018100826,-0.009838182,-0.05641133,0.025101343,0.02066164,-0.08478535,-0.03234737,0.0024155849,0.023543332,-0.028535549,-0.04999122,0.0005524045,-0.097215496,0.03474627,0.0019069682,0.040347915,-0.023461437,-0.007995815,-0.013179841,-0.066996664,2.4005619e-33,-0.0706518,0.002719601,-0.0036593815,-0.022310164,-0.05268765,0.012721533,-0.013786099,-0.14516166,-0.0033087102,0.04113643,0.04860708,0.026694657,0.0022195794,0.0088315625,0.028081888,-0.017074134,0.0328325,0.00096036313,0.09822324,0.0065470277,0.033520676,0.11440212,0.030622248,0.06478463,-0.02357111,0.10048431,-0.041434612,0.04047153,-0.025466217,0.0045668073,0.008560654,-0.019668229,-0.07769292,-0.060525987,-0.018999357,-0.023958255,0.04581214,-0.003129945,-0.052386582,-0.0062973793,0.05941968,-0.003584158,0.002867577,0.15827869,-0.036884867,-0.07479372,0.06889488,-0.027710633,-0.014873554,0.010659051,-0.02768638,-0.04464195,-0.032866392,-0.08967999,-0.01479311,-0.053243894,-0.0049085473,0.03820727,0.051891975,-0.02260523,0.033034775,-0.06314179,0.0043411446,-0.06140239,0.02199296,-0.009827642,0.053625256,0.020807983,0.008273043,0.06609688,0.03373152,0.09573834,0.13444178,-0.030186828,-0.05156394,-0.009566377,-0.046229932,0.06932179,0.057630423,-0.11416636,-0.031991832,-0.00066542113,0.026452256,-0.044617746,0.06507228,-0.11696032,0.07457187,0.022230344,-0.062330935,0.041871145,-0.031975985,-0.0023272657,0.0017889835,0.0713413,-0.03193887,-1.5502492e-08,-0.0412011,-0.054099,0.012802534,-0.039761156,-0.027760057,0.0279504,0.015556809,-0.014649026,0.063092485,0.053408284,0.07297596,0.011418391,0.016663948,0.0215658,0.047565706,0.0058561373,0.03988123,0.041688845,-0.10159479,-0.06914785,-0.05380872,-7.585195e-05,-0.016357306,0.07188331,0.028453324,0.04774252,0.015446269,0.079720974,0.055502303,0.0042644353,-0.03749378,0.027524283,0.0012584655,-0.04616325,-0.03520016,0.06888794,0.019522034,0.026726296,0.004062684,-0.06453956,-0.11053174,0.067457214,0.019091653,0.015239621,-0.02153527,-0.06587857,-0.072995566,-0.03542341,-0.039272733,-0.04022481,0.027580086,-0.04538773,0.004497423,-0.022909254,-0.016174618,0.05992906,-0.010969464,0.02129064,-0.016883198,0.010401383,0.069140926,-0.015784398,-0.0018027247,-0.06293484 +2.4.1.164,Requires Mn2+.,384,1.0,-0.036360487,-0.044458427,0.017822001,0.02654448,0.022565527,-0.07774763,-0.01671729,-0.0066741058,-0.08113136,0.008605609,0.037501145,-0.00853473,0.038291153,0.046258923,0.035204828,0.017164793,0.008483622,0.0010981181,0.022155419,0.043888234,0.09535097,-0.047738057,0.035636567,-0.10649236,0.080589876,0.038108997,0.021358317,-0.020172775,0.047707476,-0.022710444,0.001964823,0.07182767,0.03759382,-0.07103112,0.027451148,0.03208132,0.02418689,-0.031265844,-0.06567195,-0.0353328,-0.04206804,0.0073473584,0.111062475,-0.0032721923,0.010026853,-0.052635245,0.08713465,-0.06195826,0.032884475,0.050265517,-0.04517185,-0.010509251,-0.038998242,0.06577855,0.007258663,-0.013984565,-0.08798442,0.031221677,-0.020264747,0.020340305,-0.030886542,-0.06213404,-0.027272224,0.036563847,0.08422962,0.0193712,0.016521063,-0.05247887,-0.027940663,0.04684452,0.027259313,0.0340272,-0.06437856,0.02126383,-0.024103496,0.0154093485,0.071803205,-0.052876625,0.09380725,-0.0075167003,-0.11221875,-0.0030692108,0.02679672,-0.006094525,0.10713053,0.07699597,0.012755593,-0.016074155,-0.06754226,-0.0029608328,-0.0026667763,0.034529805,-0.0109483795,0.046426535,0.02924049,0.003930778,-0.03416443,0.031399682,-0.0929341,0.09565302,-0.01218027,0.035898115,-0.07906176,-0.0095144715,0.026446966,-0.07083552,0.06617603,0.040388364,-0.058188744,0.04259121,0.102053724,0.028116403,-0.0054726633,0.00010419161,0.023108644,0.028096316,0.024296738,-0.03508994,-0.00081681664,-0.0015044805,0.0229969,-0.01756427,-0.09027102,-0.007468594,-0.07151089,-0.034110405,0.0024530445,-2.1413545e-33,0.017724067,0.051661883,-0.021066902,0.043503698,-0.01049654,0.04684857,-0.049679115,-0.037014585,-0.004570793,-0.09597654,-0.09281623,-0.053237706,-0.020317584,0.0834843,0.04281833,-0.119611666,0.052882504,-0.017666025,0.14997219,-0.0137100015,0.020340055,0.0016038642,-0.02323011,-0.022663647,-0.013719981,0.07186442,0.13971443,-0.05194357,0.07355635,0.025671242,0.0034975566,-0.08866127,-0.06837138,0.0008731175,0.013852457,0.06542914,-0.11089267,-0.023947844,-0.010690566,-0.025923576,-0.023453522,0.08276505,-0.1598188,0.018604605,0.037131157,-0.077226475,0.0588696,0.04911015,-0.039315026,0.043499716,-0.028326973,0.057479832,-0.01836195,0.0353466,-0.021296928,0.016664,0.08537686,0.019563615,0.07890358,0.08904385,-0.05539112,-0.01854758,0.08613782,0.10673294,0.01158494,0.034094516,-0.04567807,-0.04347245,-0.030515159,0.024576593,0.012338733,-0.10936096,0.076678,0.050040204,-0.021210358,-0.018100826,-0.009838182,-0.05641133,0.025101343,0.02066164,-0.08478535,-0.03234737,0.0024155849,0.023543332,-0.028535549,-0.04999122,0.0005524045,-0.097215496,0.03474627,0.0019069682,0.040347915,-0.023461437,-0.007995815,-0.013179841,-0.066996664,2.4005619e-33,-0.0706518,0.002719601,-0.0036593815,-0.022310164,-0.05268765,0.012721533,-0.013786099,-0.14516166,-0.0033087102,0.04113643,0.04860708,0.026694657,0.0022195794,0.0088315625,0.028081888,-0.017074134,0.0328325,0.00096036313,0.09822324,0.0065470277,0.033520676,0.11440212,0.030622248,0.06478463,-0.02357111,0.10048431,-0.041434612,0.04047153,-0.025466217,0.0045668073,0.008560654,-0.019668229,-0.07769292,-0.060525987,-0.018999357,-0.023958255,0.04581214,-0.003129945,-0.052386582,-0.0062973793,0.05941968,-0.003584158,0.002867577,0.15827869,-0.036884867,-0.07479372,0.06889488,-0.027710633,-0.014873554,0.010659051,-0.02768638,-0.04464195,-0.032866392,-0.08967999,-0.01479311,-0.053243894,-0.0049085473,0.03820727,0.051891975,-0.02260523,0.033034775,-0.06314179,0.0043411446,-0.06140239,0.02199296,-0.009827642,0.053625256,0.020807983,0.008273043,0.06609688,0.03373152,0.09573834,0.13444178,-0.030186828,-0.05156394,-0.009566377,-0.046229932,0.06932179,0.057630423,-0.11416636,-0.031991832,-0.00066542113,0.026452256,-0.044617746,0.06507228,-0.11696032,0.07457187,0.022230344,-0.062330935,0.041871145,-0.031975985,-0.0023272657,0.0017889835,0.0713413,-0.03193887,-1.5502492e-08,-0.0412011,-0.054099,0.012802534,-0.039761156,-0.027760057,0.0279504,0.015556809,-0.014649026,0.063092485,0.053408284,0.07297596,0.011418391,0.016663948,0.0215658,0.047565706,0.0058561373,0.03988123,0.041688845,-0.10159479,-0.06914785,-0.05380872,-7.585195e-05,-0.016357306,0.07188331,0.028453324,0.04774252,0.015446269,0.079720974,0.055502303,0.0042644353,-0.03749378,0.027524283,0.0012584655,-0.04616325,-0.03520016,0.06888794,0.019522034,0.026726296,0.004062684,-0.06453956,-0.11053174,0.067457214,0.019091653,0.015239621,-0.02153527,-0.06587857,-0.072995566,-0.03542341,-0.039272733,-0.04022481,0.027580086,-0.04538773,0.004497423,-0.022909254,-0.016174618,0.05992906,-0.010969464,0.02129064,-0.016883198,0.010401383,0.069140926,-0.015784398,-0.0018027247,-0.06293484 +2.4.1.165,"Requires Mn2+. The enzyme, found in mammals, is only active with substrates containing (2->3) linked sialic acid residues [2,3]. It is active with glycoproteins, but not with gangliosides. The enzyme is involved in synthesis of the blood group antigen Sda.",384,1.0,-0.021743983,-0.12165094,-0.069056116,-0.010424877,0.026507882,-0.005017171,-0.039880387,0.045782473,-0.041454826,0.03817752,0.037617892,-0.026823664,-0.047407873,0.051751547,0.042802047,0.054504085,-0.024936732,-0.06711015,0.047438264,-0.009189001,0.030090049,-0.023730252,-0.023882952,-0.07997427,0.052832067,0.0472946,0.01058424,-0.06994576,0.03383111,-0.048016183,-0.0331786,-0.058388706,0.07374734,-0.033120066,0.06687519,0.01891367,-0.034418166,-0.012236906,-0.014452464,0.02456423,0.051804848,-0.0405165,0.025218574,-0.06404442,-0.021888014,-0.051887464,0.03240982,-0.056478806,0.008415866,0.080658935,-0.041397568,-0.052007988,-0.004766004,0.055807088,-0.043749932,0.0023157601,-0.0735294,0.026493054,-0.0044763763,0.044283096,-0.014241043,-0.014347375,0.017503807,-0.027783165,0.046286136,-0.056759275,-0.011076903,-0.07715585,0.0262029,0.03110836,0.050204236,-0.04078085,-0.05249844,0.042509563,-0.031740375,0.006740947,0.0939358,0.004852218,0.10357204,-0.06053173,-0.023249174,0.019026259,0.07852929,0.11593586,0.058978643,0.14624666,-0.0282579,0.04409935,-0.07699135,-0.0076176603,0.04140532,0.003207725,-0.0414918,-0.05792688,-0.02952021,0.011620694,0.0021819694,0.0021887806,0.029548578,0.013795708,-0.013345397,0.019073954,-0.05745627,-0.07374771,-0.01312187,0.046307094,-0.015702084,0.017485306,0.01864683,0.041290216,0.041505456,0.04476975,0.03138421,0.044472545,0.024518624,0.008111247,0.039043143,-0.086941555,-0.021631034,-0.01593558,0.030468874,-0.011809946,-0.0007073754,0.043323815,-0.010405204,0.10810177,-0.0070937746,-1.6669123e-34,0.07998233,0.0047033797,0.0047903513,-0.069478944,-0.05733229,0.02902527,-0.01389099,-0.040988617,-0.00083012145,-0.017251732,-0.066307664,-0.11967847,0.030949578,0.12813023,-0.0053553367,0.0071359165,0.08359438,-0.116543375,0.110163674,-0.057361767,-0.0015656137,0.05294829,-0.010303466,-0.0076048067,-0.02918804,0.07927745,0.03807595,0.033669543,0.0920599,0.010076291,-0.049365006,-0.102423266,-0.065585,0.03047495,0.039805062,0.015330811,-0.035462946,-0.0223734,-0.009186033,0.024124147,0.047757864,0.06096082,-0.08144522,-0.020891856,0.057401463,-0.043032393,-0.04540865,0.006782202,-0.021708727,-0.029965157,0.00377952,0.027932972,0.06255085,0.02192502,-0.015934525,0.03478296,0.0041538584,0.0026009765,0.018688304,0.07480849,0.00039005547,-0.0054758405,0.007657588,0.0854725,0.023421424,0.026555227,-0.065128244,-0.087593295,-0.05140998,-0.039116755,0.028750125,-0.100998566,0.014186731,-0.0012948689,-0.044711877,-0.09049443,0.013665859,0.02495321,0.033947058,0.0008969042,-0.047310553,-0.011298036,-0.01891478,0.027869305,-0.08087564,-0.0097277425,0.010435427,-0.14073591,-0.023042947,-0.027304854,0.0031539686,-0.029493503,-0.07817355,0.08678693,-0.025982838,-2.9283228e-33,0.057456814,-0.009878359,0.07072629,-0.106029294,-0.10230799,0.09782123,0.051274657,-0.11544655,0.056451388,0.05774541,0.022900272,0.015883667,-0.04555867,-0.06530793,0.056968387,0.008649597,-0.037583552,0.11530103,0.04458561,-0.020280126,0.0016212179,0.10622916,0.024526514,0.09548491,0.084551446,-0.018712202,-0.07477216,0.056286827,-0.01136827,-0.0058724904,-0.04172255,-0.0017401271,-0.047961857,-0.1299468,0.0073925774,-0.007815538,-0.0186262,-0.050400194,0.051583488,0.011432612,0.014293033,0.029757898,0.02965414,0.13494247,0.03792142,0.025524082,-0.021730658,0.046077352,-0.06791631,-0.031238424,-0.033801105,-0.04586227,-0.026772471,-0.019656396,0.026063345,0.041870825,0.029458586,0.030687235,-0.0026191925,-0.072233036,-0.05217111,-0.038741335,-0.039912276,-0.023094233,0.048313044,0.06597126,0.031860296,0.015245256,0.02636698,-0.023353506,0.036229964,0.016084695,0.007887614,0.054907363,-0.012936159,-0.02462354,-0.12214915,-0.012708406,0.06262608,-0.07875795,-0.021257292,0.048101697,-0.009019908,-0.0329243,0.033904504,-0.039396577,0.025372837,0.08040461,0.0018940754,0.032931987,-0.031765584,-0.068147905,-0.03712179,0.08828097,0.040675715,-4.161919e-08,0.066320404,-0.06537857,-0.030835103,-0.12708949,-0.084725834,0.010897464,-0.013594173,-0.02724398,0.07459001,0.021947306,-0.016200593,0.042156447,-0.016168626,-0.01610859,-0.003141442,0.05227042,0.043317318,0.0001202425,-0.07800597,-0.02698762,-0.020745676,-0.006041105,-0.10340091,0.082970314,-0.004192887,-0.02223408,-0.035553094,0.054604076,-0.060665175,0.0109754335,-0.011753281,0.04463341,0.0057702726,-0.054437716,-0.035208404,0.06590862,0.059938293,-0.05260194,0.029048013,-0.0090498915,-0.048937842,0.028958838,-0.011046133,-0.0418722,-0.03542518,-0.017472945,-0.048704986,-0.009227207,-0.00907589,-0.024927339,-0.054599714,-0.10604298,-0.023649683,-0.06265672,-0.10373219,-0.0021430752,-0.05497833,-0.041118994,0.014822444,-0.04393491,0.09749849,0.046447393,0.13000585,-0.06560662 +2.4.1.166,The 3F position of raffinose can also act as galactosyl acceptor; the enzyme is involved in the accumulation of the tetrasaccharides lychnose and isolychnose in the leaves of Cerastium arvense and other plants of the family Caryophyllaceae during late autumn.,384,0.99999994,0.01571242,-0.13808404,-0.14544633,0.0069114123,0.07799964,0.06474453,-0.005065195,-0.015936347,0.05626148,0.038793888,0.04384013,-0.030255234,-0.06847265,0.05474683,-0.06287573,-0.0708208,-0.11092275,-0.016322581,-0.04427793,0.014489558,0.10994303,-0.05731499,0.029517738,0.06588915,0.02560716,-0.12104315,-0.11383459,-0.059900813,-0.0047670715,-0.12549087,0.042580042,0.10765069,0.071857736,-0.073241845,0.035928037,0.041472863,-0.018355863,-0.088226184,0.0033402466,0.047610797,-0.040470745,-0.023136653,0.0038801085,-0.026697163,-0.018686486,0.016795928,0.027480055,0.0398296,0.06853695,-0.015341413,-0.0037680354,-0.074198626,-0.058576368,-0.02791716,-0.009402999,0.068167314,0.085327186,-0.013371922,-0.025763014,-0.001271715,0.067240216,0.040381253,-0.0804694,0.0066227475,0.010135383,-0.041193802,-0.028256882,-0.057809465,0.03627521,-0.014924429,-0.016295277,-0.05053555,-0.01767484,0.0073468382,0.014718464,0.06873726,0.019613527,-0.0006999408,0.043270003,-0.008861476,0.014708774,0.013108027,0.012222598,9.4093724e-05,0.0066390038,0.015487095,-1.0307311e-05,-0.0019393729,0.011862418,0.056475915,0.04361234,-0.06272376,-0.03612138,0.055810116,-0.0746016,0.06764853,0.11652464,-0.08551229,0.010569716,-0.038806032,-0.011596298,-0.046843752,0.008142688,-0.025506886,-0.030650789,0.09016862,-0.056026023,-0.007348456,0.0029957169,-0.015225311,-0.05902577,0.019926127,0.0023880496,0.009657293,-0.08669361,0.07368088,-0.0059128297,-0.1251505,-0.04545798,-0.059504632,0.008899013,0.03593592,0.04676424,0.033121906,0.0017695917,0.07297756,-0.043472465,4.951653e-33,0.06989908,0.031250704,-0.023442721,-0.028461939,0.017930558,-0.0632759,-0.055703875,-0.002534388,-0.04802561,-0.016919121,-0.08929731,-0.049140453,0.024224345,0.021259034,-0.014451818,0.029196732,0.011456731,-0.00295403,-0.01109712,0.0002673458,-0.034646545,0.054460786,-0.074479535,-0.045368563,0.04469397,0.024473542,-0.022147896,0.0018921023,0.010674797,0.021432353,0.099047914,-0.058841165,-0.1079381,0.04093515,0.06428919,0.03925067,0.010793827,-0.08589813,-0.05628994,0.056652397,0.029664503,0.032274146,0.016756484,-0.005380847,0.06149457,-0.090245456,-0.003694855,-0.004807861,0.07773255,0.08202278,0.041181676,0.018503286,0.0991609,0.005212337,-0.00037730552,0.09080285,-0.015856408,0.000610059,0.05273737,-0.012734778,-0.0121605685,-0.017683107,-0.0019719226,-0.032814484,0.011562726,0.04076518,-0.0780651,-0.014022624,0.027300313,0.04425039,-0.07920385,-0.056899827,0.034428928,0.037446495,0.039919935,0.004581168,-0.008324562,-0.0071923784,0.0071259798,-0.0322262,0.029722273,0.010897543,0.021620512,0.018140865,-0.061112266,-0.009720513,0.019681135,-0.0026979134,0.021554468,0.042599227,0.022714242,-0.006032235,0.06285295,-0.018298,0.043378234,-5.559102e-33,0.12109387,-0.041713912,0.021309713,-0.07697297,-0.052321237,0.086447254,-0.050446514,-0.049065135,0.02087598,-0.03536167,0.009329642,0.010029559,0.04147668,-0.11821508,-0.0033896547,-0.060951013,0.073206015,0.08484176,-0.02580404,-0.020474628,-0.037054114,0.028839882,-0.039936434,0.0012797408,-0.024088383,-0.03331912,0.00031346094,0.041934013,-0.047977734,-0.017544743,0.018112877,-0.05729812,-0.02522584,-0.038972136,0.010609356,-0.03956509,-0.04792793,0.015684385,0.0014360343,0.0678765,-0.02506602,0.062446993,0.081697606,0.010973856,0.10698917,0.0057606436,-0.1002631,0.013543746,0.09500223,0.0388498,0.033277642,-0.071180254,-0.00499068,0.07042849,0.11515174,0.003072611,0.025593903,-0.0050435173,0.059932303,0.025447253,0.001552645,-0.008958344,0.00587085,-0.03139039,0.089545324,0.016600724,-0.11698985,0.058812816,0.044040445,0.016818454,0.10117403,0.0154474145,0.0034700213,0.096599475,-0.017376406,-0.051109385,-0.069098316,-0.03759418,-0.0029688221,-0.056258485,0.02837037,0.03098961,0.025897596,-0.0559621,-0.034752693,-0.059047043,0.008819423,-0.00092098635,0.023740353,-0.12700045,-0.0019697193,-0.029241038,0.04196562,-0.023395037,0.18413691,-3.8794287e-08,0.04787461,0.053223837,-0.044079248,-0.027602315,-0.058000866,-0.021705704,0.07531218,-0.013299874,-0.016133158,-0.07021052,0.014983666,0.10159716,0.086318836,0.0062961527,0.055929888,0.003974768,0.0037864523,-0.0042847316,-0.038573507,0.056199327,-0.038867652,0.01851405,-0.06876463,-0.00085222634,-0.01898948,0.0034867679,0.040663116,0.09224827,0.05397983,0.02766303,0.029584032,0.028931431,0.02813006,-0.02501832,-0.10193846,0.06975886,-0.0145955365,0.021667222,-0.035116848,0.02932382,0.03227814,-0.09071228,-0.009979679,-0.031575594,-0.0631202,-0.007693387,0.01743524,0.010347709,-0.012021118,-0.043747433,0.024904814,-0.022441756,-0.044083767,0.028729588,-0.087935455,-0.047751117,-0.017483907,-0.049023937,0.025620667,-0.09829011,0.009876828,-0.059791215,0.101666056,0.004456766 +2.4.1.167,The enzyme is involved in the synthesis of the trisaccharide planteose and higher analogues in the seeds of Plantago and Sesamum species.,384,1.0,-0.059311643,-0.037491914,-0.12397819,-0.043468926,-0.014962948,0.11287907,-0.08091397,0.0055962675,0.069135,0.04984793,0.09952922,-0.0787273,-0.09830436,-0.122827925,-0.019322017,-0.05177163,0.030792342,0.033998016,-0.048488047,-0.10971799,0.09312486,-0.009037696,-0.069305666,0.005754347,0.037140906,-0.0068192994,-0.027848694,-0.06069728,0.02359409,-0.05778211,-0.016435847,0.0060235164,0.1136079,-0.04608163,0.03395133,0.03267663,0.0060716458,-0.07563177,0.09751263,0.011985832,0.005230571,-0.008978394,-0.03441552,-0.04865631,-0.09226452,-0.0501189,0.017064663,0.044281356,0.049497332,0.028863527,-0.024764491,-0.06279118,-0.06491532,-0.016503774,-0.010298283,0.00014181652,0.059601486,0.09187059,-0.026822899,0.10027509,0.042679228,0.026060767,-0.014793654,0.013762379,-0.022956086,-0.06185264,-0.009630188,0.022788635,0.020144438,0.00918944,0.016905898,-0.07214604,0.011977415,0.011802756,-0.040899344,0.01772402,-0.0100579895,-0.0072353245,-0.0021934276,-0.00897454,0.030168153,0.018236052,0.04156505,0.0338721,-0.018385071,0.00508955,-0.04390823,0.024531271,0.07863398,-0.024510989,0.08951839,0.0040066466,-0.018615983,0.015222791,-0.0036526388,0.08559265,-0.034442026,-0.036620818,0.011609274,-0.093388535,0.018561034,0.06393247,0.007775874,-0.11872932,-0.055170275,0.0960407,-0.0798584,-0.0066482467,0.08022475,0.052386794,-0.017102532,0.033066615,-0.018942462,0.026007613,-0.09831539,0.10824171,0.015102217,-0.030177763,-0.01754711,-0.014301979,0.06770797,-0.06909935,0.05969329,0.062846,-0.05338582,-0.028131738,-0.072804384,-1.7312194e-33,0.06245207,0.027939135,-0.032482166,0.002854455,-0.039297085,-0.029502438,0.0050664614,-0.02349016,-0.11644801,-0.01639199,-0.10589589,-0.09818871,0.030387737,0.057308678,-0.0036800702,0.028488213,-0.043667294,-0.04868692,-0.009359921,0.011030051,0.00795682,0.054824255,-0.06444974,0.013293243,0.045853715,0.061136536,0.034880817,0.00030612087,0.07358947,-0.025761588,0.02913075,-0.02198337,-0.035890415,0.03601373,0.11612497,0.014838045,-0.0004149884,0.003837088,-0.011375139,0.05874542,0.0071052224,0.032002825,0.047175243,-0.07073474,0.05276972,-0.043741327,-0.011863426,0.028397212,0.050142463,0.042060316,-0.005135919,0.03885294,0.081180476,0.10428158,-0.036588952,0.026808426,-0.049047958,0.025764726,0.015926497,0.03361922,0.0066946507,-0.006872416,0.033533353,-0.004158999,0.009809522,0.045310482,-0.110797696,-0.07244272,0.041370988,0.076815054,-0.053653546,-0.08306312,-0.075054884,0.03743812,0.049275625,-0.08212654,-0.03066426,0.08407856,-0.025073128,0.022204114,0.049506966,-4.0834875e-05,0.020289447,-0.006183635,-0.059625857,-0.025292547,-0.06257138,0.09769637,-0.038621183,-0.023151334,0.072566755,-0.03678745,-0.026012708,0.029174821,-0.02230255,1.8313658e-34,0.047207635,-0.060260475,-0.028046524,-0.01748179,-0.060206935,-0.007523842,0.037423696,-0.05583316,-0.054741677,0.0093003865,0.017503288,0.04188242,0.041448157,-0.012526423,-0.04687369,0.049078856,0.023468643,0.07238922,-0.07690662,0.0021863016,0.007002884,0.06197769,0.036415946,-0.0074246344,0.025441257,-0.031879615,0.01514955,0.044854283,-0.024154147,0.030851487,0.04735152,-0.068102926,-0.078391306,-0.0033771107,-0.02727439,0.06886553,-0.033587005,-0.0116059715,0.016312499,0.036231574,-0.024769887,0.11447358,0.068395324,0.0035723762,0.0678371,-0.029170722,-0.09620435,0.0623683,-0.12755905,-0.018102461,0.020857327,-0.009558881,0.03627643,0.046205778,0.06435979,-0.05428557,0.0102456985,0.02442273,-0.09577514,-0.009263432,-0.019076196,-0.026086597,0.02118253,-0.055586457,0.060625315,0.06941249,-0.040689047,0.039961014,0.027231494,0.03816075,0.02758534,0.019629313,-0.021210838,0.045316372,-0.0439617,-0.08978811,-0.046499066,0.005128802,-0.0076316684,-0.03890051,-0.030975161,0.0125188185,0.042461824,-0.037470944,-0.011516939,0.029920677,-0.0008536013,0.15946284,0.08126014,0.036879215,-0.03671554,-0.07592776,0.019410944,0.07985551,0.17795232,-2.52674e-08,-0.02557443,-0.058044095,-0.017333739,-0.0662304,-0.01245796,0.010695917,0.004156692,-0.05763588,-0.019805199,-0.051077675,-0.018478893,0.06491667,-0.017488377,0.05625371,0.010828463,-0.024005402,0.05251942,0.096120596,0.015618267,0.08520566,0.029313346,0.033306103,-0.13242596,0.056144167,0.03416855,-0.0116957035,0.032716744,-0.041610595,0.018307108,0.048339557,0.0052208947,0.034646522,0.03439429,-0.060177032,-0.054882407,0.03958893,-0.028133241,0.022400798,-0.020008367,-0.036504872,0.0138207115,0.0008579717,-0.0030045938,-0.02591302,-0.025879929,-0.038159046,0.029697007,0.000121055156,0.014278089,0.024563543,-0.0115477685,-0.048435144,0.002249716,-0.058751058,-0.04935743,-0.104327336,-0.0598754,-0.012821119,0.043426286,-0.042129196,0.0011586299,-0.035183087,0.09467562,-0.006602556 +2.4.1.168,"In association with EC 2.4.2.39 (xyloglucan 6-xylosyltransferase), this enzyme brings about the synthesis of xyloglucan; concurrent transfers of glucose and xylose are essential for this synthesis. Not identical with EC 2.4.1.12 cellulose synthase (UDP-forming).",384,0.9999999,-0.012276612,-0.0047269464,-0.070220366,-0.0046552313,0.020586338,0.00642473,-0.05364165,0.046896283,0.03702569,-0.0140228635,0.04602217,-0.022629142,-0.02581396,-0.017893035,-0.05552925,-0.018543966,-0.06021171,-0.0112133995,-0.023577195,0.006764616,0.10030998,0.018373594,0.030581808,-0.0010750284,0.09490747,-0.08706645,0.010584642,-0.082981914,-0.03551459,-0.069915526,-0.0016241733,-0.04957568,0.009718851,-0.03577346,0.083328456,0.061266415,0.04783294,-0.07708679,0.018581005,-0.01683225,0.009433083,-0.0719313,-0.0035239765,-0.035573665,-0.039015733,-0.03348045,0.020194422,0.015407094,-0.0012179326,0.006559662,0.0021455574,-0.06098138,-0.03523646,-0.026254905,0.09108294,-0.0026983423,-0.087068245,-0.0067676115,0.007694696,0.032219425,0.011540719,0.097339064,-0.013590217,0.013235398,-0.0030516875,-0.10612087,0.07163694,-0.044162273,-0.008408849,0.0039637447,-0.11264711,-0.051043797,-0.0077471905,0.036861867,0.035709046,-0.0089593595,0.01852551,-0.059116237,0.071556605,-0.029823052,0.055063497,0.006941596,0.0020535465,-0.0071586934,-0.054034296,-0.05381228,0.061970927,0.03421925,-0.014685109,-0.029683534,0.07274797,-0.014816412,-0.021640563,0.008339103,-0.011274115,0.04232295,0.07673939,0.08152238,0.13458875,-0.064909995,0.021186234,0.032381702,0.038981944,-0.07854429,0.011553404,-0.04144243,-0.015851261,0.09042354,-0.00735536,-0.053069793,0.009118901,-0.08685883,-0.009506536,0.027912956,-0.013982446,0.123581775,-0.0090807695,-0.09307957,-0.05114325,-0.004904069,0.027232215,-0.02754213,0.058882497,0.0900838,-0.03890951,0.035544205,-0.053786613,9.365728e-34,-0.013763334,0.077217564,-0.03539143,-0.015675353,-0.010244859,-0.019905273,-0.05067784,0.06136797,-0.0878595,0.033202507,-0.076362796,-0.08095603,0.024221666,0.09139604,-0.061869714,-0.047321904,0.016720079,-0.038565822,0.04192298,0.0616538,0.002753453,0.04000314,0.021845508,0.020873295,0.049815584,0.07355676,-0.012832341,-0.033860818,0.072053164,-0.016017972,0.004327471,-0.045832913,-0.043679442,0.06528961,-0.00026816232,0.021940706,-0.009415411,-0.040467165,0.017659547,0.015924316,0.03622775,0.024881285,0.008755246,-0.112633295,0.083821386,0.032400094,-0.10818,0.0014533771,0.058825072,0.033118118,0.06385116,0.041160353,0.053827018,0.0495845,0.04626234,0.003122226,-0.04093,-0.0032531726,0.005146531,0.029673941,0.0030370934,0.08677686,-0.07818522,-0.021015568,-0.0107047325,0.009532954,-0.0006891936,-0.04594198,-0.085667625,0.0026584023,-0.08964322,-0.08526115,0.08561513,0.011009627,0.09339005,-0.044436656,-0.10525176,0.070663616,0.03667307,0.011738708,-0.0016125002,0.06566879,0.010670673,-0.05423632,-0.052671105,-0.04971029,-0.059873022,0.07378797,0.0061378204,0.16771145,-0.043207318,-0.04371046,-0.080774136,0.05434381,0.015110736,-3.085706e-33,0.08558332,-0.040826,0.011234638,-0.019519497,-0.01675368,0.020442862,0.052526735,-0.07954243,0.08510167,0.009803353,0.12584625,0.007863267,0.048521373,-0.033908833,0.060873758,-0.006977517,-0.09511406,0.07387336,-0.04488238,0.0113567775,0.0040774276,0.08331324,0.00022342066,0.025426848,0.0724551,-0.030574929,-0.0044326107,0.07195252,0.05503527,-0.04098298,-0.047683094,-0.057111163,-0.010332412,-0.037848808,-0.06643937,-0.009852928,-0.018222636,0.031677023,-0.0064728833,0.052883804,0.018562023,0.079152934,0.00047287205,0.027176982,0.06289279,0.07214987,-0.010295136,0.015537934,-0.004488697,0.011845058,0.036901053,0.034718078,-0.034129754,-3.876755e-05,-0.003988563,0.07022599,0.022902982,0.020299135,-0.012327871,-0.02650395,-0.07061531,-0.07594794,0.082103536,-0.06977955,0.1026007,0.018903589,-0.042139824,0.017848387,0.006629572,0.034401346,0.1002976,-0.071679704,-0.08251032,-0.006599879,-0.01598749,-0.024039337,-0.113466434,-0.061926268,0.0009925166,-0.07985415,0.012258153,0.035594694,0.09082601,-0.033895746,0.048958484,0.0029302605,0.036432847,0.062270924,-0.013140844,-0.018243644,0.00051069487,-0.04898105,-0.020443646,-0.007076022,0.06786721,-3.501575e-08,-0.02783725,-0.024317177,0.0071638655,-0.05750379,0.04800462,-0.036459886,0.0055188397,0.06735498,0.020384962,-0.0063680015,-0.0018738661,0.09585776,-0.0011054814,-0.01589936,-0.014997407,-0.05166187,-0.0166681,0.020246133,-0.02402024,-0.021615189,-0.023839084,-0.0194414,-0.10758557,0.05702733,-0.02013536,-0.109624095,0.05716096,0.016639592,0.034921873,-0.0697991,-0.030564772,0.061473306,-0.04117842,-0.013493208,-0.08238924,-0.007160946,-0.039207883,-0.06803515,0.009090152,0.043732952,0.022748461,-0.07477913,-0.03561062,-0.004500276,0.0067659845,0.01107265,-0.0031526885,-0.08989137,-0.01126229,0.009077229,0.0019578263,-0.009167348,-0.0037606913,-0.11542281,0.013222773,0.0094602965,-0.06354252,0.008821442,0.07981067,-0.017876137,-0.00013984529,-0.02409494,0.19154413,-0.051550902 +2.4.1.170,"The 4'-methoxy isoflavones biochanin A and formononetin and, more slowly, the 4'-hydroxyisoflavones genistein and daidzein, can act as acceptors. The enzyme does not act on isoflavanones, flavones, flavanones, flavanols or coumarins.",384,0.99999994,-0.05647384,-0.10646515,-0.1075639,0.018682944,0.012589367,0.048216794,-0.07440325,-0.015983213,0.008154216,-0.09324814,0.046589565,0.0034405952,-0.10036701,0.03400106,-0.044834152,0.035319526,-0.03951112,0.06748372,-0.0625877,-0.022844674,0.0032065439,-0.05759228,0.046209984,-0.03545442,-0.025818875,-0.047266386,-0.00011650085,0.010557285,0.05917101,-0.0753434,0.032148674,0.03240667,0.014386579,-0.00024846024,-0.059204806,0.053944122,0.006801549,-0.018048264,0.04860762,0.022930954,0.042212047,-0.04565597,0.05721797,-0.022936368,0.052118454,-0.12645094,-0.056994017,-0.0018228594,0.061561644,0.005863311,-0.091711625,-0.020931657,-0.014499917,0.07720106,-0.0014953252,-0.055687055,0.017141404,0.0059948238,-0.037178,0.02590502,0.045679178,-0.0963912,0.004648011,-0.014488847,-0.046467554,-0.023231084,-0.06549929,-0.021271417,0.0148117365,-0.014920984,0.009136352,-0.01813083,-0.055398725,0.044986863,-0.009416566,0.099438064,-0.08134729,0.02068008,0.012714544,-0.010496779,0.050894007,-0.03165162,0.06443846,0.081256166,0.012900341,-0.028164616,-0.086184636,-0.016745223,0.014472236,0.08949051,0.0041337786,0.049387738,0.037973132,-0.010713713,-0.0013288741,0.015590558,0.06226833,0.0321677,-0.04787583,0.020231394,-0.055992693,-0.032021455,-0.12680002,-0.040861096,-0.05197395,-0.010047844,0.0045678774,-0.022556327,0.084627904,-0.004099993,-0.04398287,-0.07332127,0.01987184,-0.027788248,-0.046263725,0.010998159,0.0054823025,-0.067896836,-0.004460957,-0.059871145,-0.08286137,0.06023885,0.14385918,0.00892122,0.033015683,-0.009151532,-0.038476218,3.973905e-33,0.058148254,0.018216759,-0.029364033,0.013171129,-0.013229936,-0.02171858,-0.015739392,0.018872783,0.012995417,-0.08157041,-0.13692242,0.06904849,-0.041874666,0.03814693,0.023016162,-0.0022691581,0.03840529,-0.050848573,0.051905807,-0.051155433,0.09311743,0.003961882,-0.07942235,0.052090656,-0.04356409,0.0076693613,-0.062248595,0.034782782,0.017957015,0.01865638,-0.018800575,-0.065888815,0.013077883,0.027714236,-0.02349431,0.0732405,-0.0754825,-0.038639702,-0.09528857,-0.0042794226,-0.03139357,-0.052940454,-0.029086068,-0.024294613,0.056747124,0.04168511,-0.08057343,0.020137308,0.06504365,0.067283586,0.015089464,0.009228276,0.05969783,0.0005652799,0.016950583,-0.004116243,-0.011108018,0.020222021,0.032798797,0.030271119,-0.0034104406,-0.0074495818,-0.004713806,0.04531594,-0.09327567,0.054062042,0.010823948,-0.0275038,0.016834725,0.05804077,0.043101214,-0.026535423,-0.009957008,0.06561016,0.08783763,-0.046286326,0.025333095,-0.046614744,0.005922648,0.008084461,-0.013632079,-0.010206809,-0.011103892,0.071835384,-0.10682775,0.009897516,-0.022660306,0.0035037224,0.065526985,-0.004597442,0.013803802,-0.04698163,-0.01920419,0.028668981,0.05225357,-5.0489767e-33,0.027787868,-0.02541257,0.013400914,-0.025514726,-0.0152360825,0.08493324,0.000533044,-0.04408434,0.057900686,-0.0074015884,0.094356894,-0.083962716,-0.021948725,-0.000460983,-0.038562313,0.018518457,0.0021032665,-0.0003439107,-0.005513793,0.03222011,-0.04833354,0.06449933,0.013455654,0.11624712,0.07325695,0.02767804,0.115182385,-0.025530415,-0.017590914,0.11365824,-0.05035062,0.011386765,-0.034186702,0.019054258,0.007516207,0.0601811,-0.042857904,0.040284514,-0.074404426,-0.026338413,0.0076944414,0.01998955,-0.034990206,0.06951474,0.049254708,0.028138654,-0.042772174,-0.015717845,-0.026465453,-0.021534212,0.03377696,0.089869745,0.011409935,0.047916744,0.06050529,0.03644403,0.025916925,-0.010059977,0.053731866,-0.007739256,-0.045891494,-0.10935198,0.03516734,0.025492253,0.090807416,0.060989004,0.013275578,0.07125823,-0.01445861,-0.02023487,0.10484504,-0.08105497,0.1028917,0.107579656,0.03028102,-0.007835587,-0.014511764,-0.009040428,-0.08990897,-0.016761282,-0.038638014,-0.020227235,0.019944428,-0.09249768,-0.07641964,-0.040236913,-0.01752964,-0.013415202,-0.007971129,0.1003993,0.010132891,0.104085796,-0.006075363,-0.07186033,0.039016627,-4.064242e-08,0.027894868,-0.029820966,0.1010829,-0.019034393,-0.011856257,0.020003568,-0.053609326,-0.0285513,-0.024517454,0.01999187,-0.045213558,0.12622145,0.007858852,0.0019035975,0.0049454165,-0.06808533,-0.034221712,0.0203352,-0.018908395,0.006533108,-0.12110355,0.0417476,-0.08536273,-0.029279029,-0.02558654,-0.048991065,-0.05443398,0.03582014,0.13892582,0.01776961,0.06398326,0.02458278,0.055091877,-0.053168625,-0.15963776,0.03824932,0.05369429,-0.039042614,-0.057300825,0.034656074,-0.061895963,-0.08333815,0.0018961679,-0.025009384,-0.021273363,0.004410093,0.03648323,0.0065307333,0.008156837,0.025690163,0.017197587,-0.019569974,0.009795526,-0.008978351,-0.026082885,-0.040060654,0.009520094,0.0154088205,-0.024391882,-0.07336309,-0.085154496,-0.02641787,0.17807135,0.024595661 +2.4.1.171,"Brings about the biosynthesis of the toxic substance cycasin in the leaves of Japanese cycad, Cycas revoluta. ",384,1.0,-0.026804427,0.065916926,-0.008690338,-0.02232495,0.040367734,0.023371551,-0.021385456,0.08051074,0.019360648,0.07053411,0.0427978,-0.09497529,-0.0042908923,0.024799295,-0.08145182,-0.039848346,-0.020687798,0.060747076,-0.014669185,0.038464155,0.017094499,0.044963084,-0.022114746,0.05722552,0.007995124,-0.017264396,-0.032376572,0.030993659,-0.006041047,0.019440899,-0.046697322,-0.009582499,0.028532445,-0.083499685,0.04343432,0.01438453,0.07700279,-0.035320908,0.075336896,0.0004569576,0.004940888,0.027196229,0.0037284999,0.03513998,0.041360326,-0.012890783,-0.00740449,-0.030639084,0.030091656,-0.05023447,0.03553006,0.0057675755,-0.08935041,0.08078984,0.029914785,-0.055331226,-0.056949686,-0.03740505,-0.024393385,-0.028358473,0.010245663,0.018232832,-0.023421546,0.024288839,-0.05220163,-0.04608912,-0.07247522,0.014092825,-0.026781356,-0.0073427977,0.0019397286,-0.10382252,0.011132309,-0.0026919688,-0.039850626,0.09339669,0.03884079,-0.08057141,-0.099683955,-0.07621184,0.07864359,0.02699281,0.041048072,0.097483754,0.024289694,-0.029143948,-0.027158739,-0.009037485,0.019679053,0.09331948,0.10665852,0.06541611,0.027410906,-0.026639752,-0.08895791,0.004528811,0.028937882,-0.01674213,0.06796459,-0.018348524,0.02516774,0.07104864,0.025523225,-0.13376842,-0.032959945,0.06026202,-0.06022514,0.02301322,0.01703789,-0.05696495,-0.040014964,-0.010674952,-0.068469025,-0.021230016,-0.020659981,0.12504306,-0.022513995,-0.021377295,-0.06395208,-0.04298541,0.028509347,-0.025082465,0.038436323,0.09095229,-0.019145252,0.02037121,-0.041189574,-4.6658773e-34,0.023191595,-0.036921777,0.016076367,0.030485151,0.01284081,-0.039208177,-0.046931706,-0.029951287,-0.02470601,-0.053899795,-0.09521733,-0.13615966,-0.051268198,-0.049678583,0.0018683455,0.07099595,-0.10417407,-0.12764902,0.054484565,-0.0359399,0.030775765,-0.012261938,-0.05839057,-0.059865035,0.044978563,0.07276078,-0.02076692,0.010967385,-0.022428436,-0.0035889351,0.014338214,-0.044768497,-0.02274168,0.015813727,0.044200096,-0.008869722,0.0062025124,-0.030283965,-0.029423524,-0.012231353,-0.021246353,-0.036573745,0.052082006,-0.028298933,0.06564551,0.022165757,-0.08653185,0.0038814915,0.026214609,0.025450848,0.04290215,-0.03930317,0.050979737,0.092141286,-0.07984656,0.072786964,-0.0038257148,-0.027017117,-0.024727449,0.069354065,0.041118626,0.11384061,-0.058860805,0.04544704,-0.012834575,0.03901694,-0.03926972,-0.078284,-0.104121156,0.020806627,-0.053178634,-0.08355745,0.020431168,-0.053832937,0.08723746,0.001978848,-0.020627314,0.066247605,-0.03069981,0.027239377,-0.048213843,-0.031772926,-0.12484571,-0.0024295594,0.0072801393,0.06614172,0.081425324,-0.06260716,0.016969208,0.059605338,0.09538713,-0.058291476,-0.012308012,-0.03387768,-0.05791204,-1.5567882e-33,0.01639843,-0.029261345,0.018848825,-0.02473915,-0.0025084394,-0.028838761,-0.07691333,0.0036093048,0.026057955,-0.055459928,-0.051109023,-0.026612518,-0.0520066,0.053290926,0.008797307,0.019406045,0.08889177,0.094305396,-0.033576827,-0.010450626,-0.025174865,0.0077929897,0.027432887,-0.011061696,0.10590982,-0.011983507,0.041527517,0.044621255,0.05182303,-0.013657263,-0.022835298,0.090540916,-0.038571715,-0.033220716,-0.045322914,-0.012243864,-0.05099058,-0.0653274,0.054076917,0.036578964,-0.036928445,-0.0047000633,-0.02691891,0.05688373,0.05169109,0.039719135,-0.08809094,0.02412853,0.009919767,0.019289298,0.1081335,0.050251666,0.026887542,0.02914322,0.0801884,0.06230251,0.07533853,0.05970929,0.12661064,-0.00999149,0.04619694,-0.020878071,-0.06117532,-0.040156398,0.071986474,0.04776018,0.013755651,0.037322763,-0.0074437624,-0.0031039545,0.06638898,-0.009904752,0.011037994,0.0088869,-0.077944905,-0.014689607,-0.057100784,-0.050771773,-0.0037208376,0.04360565,-0.012452709,0.027242033,0.07298649,0.05473426,-0.069765456,-0.058572143,-0.06073825,0.11083335,-0.009035467,-0.05728625,-0.022199478,0.0047796885,0.020669745,0.06408041,0.018270303,-2.4575838e-08,-0.021759426,-0.16963555,-0.035377376,-0.075727046,-0.03209797,0.031291272,0.036981963,-0.0002368177,0.025349831,-0.00717231,-0.0044086487,0.09789259,0.012900252,0.033374608,-0.080477335,0.05842533,-0.010537365,-0.01689089,-0.00017220994,0.015950605,-0.068634294,0.042725857,-0.10718528,0.034974203,-0.010215659,-0.08719315,0.033547655,0.03238427,0.017029962,-0.031999983,0.02013757,0.009444132,-0.024434986,-0.026582336,-0.035289124,0.04788109,-0.08034619,-0.07622978,0.008125408,-0.047615193,-0.05588289,-0.011658331,-0.02136817,0.0105093215,-0.010471208,-0.063014895,0.056894723,0.07844436,0.03162084,-0.046554577,0.034331977,-0.025830653,0.039493,-0.0824644,-0.020194672,-0.019907666,0.07099521,-0.0057220333,0.014677746,-0.0075219646,-0.008138739,0.038453847,0.15896113,0.045615282 +2.4.1.173,Not identical with EC 2.4.1.192 (nuatigenin 3beta-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3beta-glucosyltransferase).,384,1.0,-0.05186554,-0.031991262,-0.122397594,-0.045068376,-0.0059785936,-0.04142773,-0.039809577,0.08119627,0.12057096,-0.08885075,0.036811404,-0.046091147,-0.07015053,-0.027399361,-0.052762613,-0.12822258,-0.0775777,-0.017044358,-0.002650468,-0.023920747,0.050379023,0.053081177,0.046653166,0.011002283,0.051427796,0.008673872,-0.0063022007,0.030091109,0.034103673,-0.07236591,0.0013980953,-0.015170374,0.001938428,-0.055868573,0.03792851,-0.0073010605,-0.03132628,-0.058850657,-0.006576687,0.012203996,0.081456766,-0.02844147,0.035740152,0.017469838,0.014596465,-0.010200908,-0.074011,0.014897651,0.0018664117,0.012271791,0.007089041,-0.039063063,-0.078296155,0.047110137,0.07793936,-0.02814519,-0.12634256,-0.042003572,-0.023982123,0.07888574,-0.048829727,0.010852403,0.024437478,0.0053856256,0.043179724,0.017476125,0.09623604,-0.15708685,0.0045063775,-0.021461869,-0.059299834,-0.00751736,-0.0019284431,0.096202366,-0.01679882,0.09608581,-0.03319095,0.03951316,-0.034281917,-0.07477588,0.041593157,-0.039755225,0.027910847,0.024746984,-0.0024840694,-0.055484686,0.03836712,-0.021214306,0.0003697601,0.02863598,0.044520017,0.02279836,0.02959806,0.0392656,0.011126564,0.0403116,0.0008195173,0.088279024,0.06383279,0.0088029625,0.030149715,0.093853034,-0.064433515,-0.021839976,0.0020526906,0.0538587,0.030497998,0.035107885,0.028349677,-0.031980984,0.007385391,-0.016479174,-0.0039933426,0.0028508794,-0.06534585,0.027163154,-0.0108086765,-0.06933837,0.045902744,0.06827804,0.02894613,-0.08902743,0.072383046,0.011905939,-0.04054904,0.06864143,-0.042230446,3.9176997e-33,0.01945486,0.036235753,0.06972862,-0.015999828,-0.04423474,0.004938239,-0.13580756,0.0010485612,-0.05837315,-0.026279164,-0.1510921,-0.039123993,-0.01328173,0.04122648,0.027878532,0.034943298,0.02085861,-0.0076319743,0.0045985086,-0.0069481963,0.03162867,0.11059248,-0.0018916235,0.0060311514,0.09990972,0.03838068,-0.033946466,0.011977566,0.017419009,-0.006653267,0.008293331,-0.052834924,0.023269834,0.0030170435,-0.016295763,0.011044817,0.005657387,-0.052211907,0.01660367,0.07695846,0.07006827,0.08337652,0.07877425,-0.102319665,0.060004123,-0.026467295,-0.023080131,-0.008470451,0.089536175,0.0711131,-0.03674883,0.017664157,0.06684867,0.00088374485,0.06301676,-0.04530737,-0.00088132726,0.02706723,0.033515044,0.09592769,-0.0029769961,0.07277397,-0.020425955,-0.039431773,-0.042248633,0.057952017,-0.08246564,-0.037027616,-0.07247522,0.01121096,0.018536068,0.026626403,0.075184844,0.0022357565,0.07091071,-0.07189201,-0.06320433,0.06805621,-0.052220825,-0.012425844,-0.07709768,0.09483532,-0.020040978,-0.0037892521,-0.15808368,0.05839067,0.028140139,-0.004673742,0.03199088,0.035823416,0.022898441,0.065698475,-0.081048384,-0.038638428,-0.029828677,-4.963626e-33,-0.02793698,0.017147452,-0.057701174,-0.012145543,-0.037831753,0.008508727,0.013944333,-0.0062487465,0.04739327,0.03745422,0.17482989,-0.038850497,0.02244895,-0.10661484,0.056071673,-0.048293415,-0.043273397,0.028630855,-0.03168779,0.026507927,0.05302645,0.039415795,-0.0059036557,0.06146515,0.050048567,-0.0073607313,0.012868282,0.044467665,-0.035406947,-0.066835396,-0.074674666,0.014126473,-0.06653563,-0.006408078,-0.07375356,-0.02653464,0.028120654,-0.017184151,-0.019382454,-0.04646059,-0.022919465,0.087027244,0.06471234,0.08710242,0.05640118,0.07659009,0.07913308,0.0044978596,0.03057976,-0.049459703,-0.026423568,-0.0403684,-0.0117331175,0.032194104,0.0537636,-0.00085376727,0.019887544,0.0019345907,-0.066287704,0.0010468041,0.011211106,-0.042687856,0.03419078,-0.06279019,0.05142376,0.014788914,-0.064944744,0.005758982,0.03760305,0.0890663,0.004825657,-0.11040254,-0.057806533,-0.03976023,-0.02445883,-0.07130958,-0.02855787,0.01355773,-0.024514467,-0.11364397,0.01114946,-0.00996547,-0.014858597,-0.050324313,-0.03404547,0.053325653,0.055986065,0.015401245,-0.026087139,0.05859625,-0.07753407,0.050372213,-0.07354339,-0.040307146,-0.050521094,-3.364931e-08,0.086662196,-0.009601864,-0.040380355,0.03394805,0.012283281,0.033165853,-0.04400714,0.045576386,0.01926688,0.040200677,-0.0068711913,0.042111605,-0.0093787005,-0.09152163,-0.026554149,0.0077951117,-0.08617862,0.052663065,0.014513146,-0.0013420044,-0.034157615,0.063514486,-0.041583467,-0.030300923,-0.04041804,0.008999713,0.026857253,0.016162585,0.021697002,-0.06988797,0.033804096,0.037626438,0.039932195,-0.061989218,-0.054457888,-0.074761674,-0.014033442,0.08126869,0.008923595,0.053267855,0.004773886,-0.049105596,-0.046676803,0.034346707,0.0075200433,-0.002625447,0.0077672903,-0.026840443,0.025617804,-0.09137862,0.010416717,-0.03766743,-0.028845977,-0.03251708,-5.823647e-05,-0.05406042,-0.07584822,-0.007853998,0.07183437,0.006468707,0.03952527,-0.112454295,0.06874684,0.062329803 +2.4.1.174,"Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core.",384,0.99999994,-0.060491413,-0.17084241,-0.027242722,0.017870871,0.042215195,0.024756834,-0.044233143,0.04692465,-0.015541587,0.041451033,0.057226643,0.05040854,0.010964923,0.01843318,-0.06824961,0.06449752,-0.08514376,-0.036115326,0.031599935,0.007874123,0.07352221,-0.060118914,0.003249162,-0.04053408,0.0019279056,0.040742043,0.045379866,-0.017864823,-0.02940387,-0.016924396,-0.06909559,0.012129866,0.06084389,-0.03901145,-0.011169212,0.10921902,0.036423847,-0.022906367,0.024831591,-0.028373342,0.0034513962,-0.045799416,0.076301664,-0.056284465,0.08202984,-0.114904195,0.057447765,-0.06368599,0.023554627,0.098178886,-0.00794135,-0.000949543,0.014149486,0.009737867,0.053854074,0.037375614,-0.07894978,-0.026023084,0.0504523,-0.0047507803,0.028180478,0.053072356,-0.06066774,-0.08930514,0.015615284,-0.06156579,0.06285397,-0.030039174,-9.3288756e-05,0.033537813,-0.010222851,0.022181155,-0.04439949,-0.0006245731,0.0010890584,0.102326825,-0.008976969,-0.018668355,0.0062876544,-0.0681983,-0.001242344,0.012839247,0.035877578,0.13562793,0.01739873,0.0071526454,0.064035274,0.021335863,0.0064213416,0.023369493,-0.015236062,0.008297667,-0.04215021,-0.00045003986,0.017384632,0.0005746283,-0.008225591,0.044453286,-0.01574369,0.0110450685,0.023105416,-0.010069383,-0.038150724,-0.09853415,0.01449924,-0.05568243,0.015407384,0.10937428,0.014422065,0.028163396,0.026769632,0.011678122,-0.014767968,-0.0042680716,-0.061133474,0.17050481,0.039119948,-0.069594294,-0.09118649,0.04971047,0.029425854,0.087688684,-0.031654377,0.064827286,-0.06759364,-0.029646643,-0.02259862,9.078693e-34,0.102752134,0.06658578,0.06184826,-0.019499283,-0.045853533,0.0010636031,-0.10419623,-0.046034366,0.059912354,-0.011094738,-0.03578125,0.011157008,0.012046898,-0.0088799335,-0.04974493,0.00027286544,0.065142885,-0.06705867,0.0996565,0.020593347,0.019127805,0.071621,-0.063187525,-0.016832253,0.019515939,-0.024058266,0.07111728,-0.0071409917,0.061420288,-0.012134265,0.05504734,-0.1237915,0.023745108,-0.024975326,0.09012433,-0.0030953987,-0.0103538735,-0.059334673,0.01559142,-0.003289938,0.09228262,-0.0531135,-0.028552268,0.030849313,0.02469147,-0.06649488,-0.0057420135,-0.00035764065,-0.0076427213,0.0064333677,0.020875731,0.03704618,0.044464536,0.064803205,-0.059242852,0.0014159556,-0.02680653,-0.03944095,0.024597183,0.08298977,0.029030414,-0.074330404,-0.032069243,0.04037112,0.04332598,-0.021718657,-0.071081616,-0.00046715667,-0.052770976,0.020138063,-0.07578152,-0.13326408,0.027560838,0.03367596,-0.013530268,0.007493172,-0.039103985,0.0675124,-0.0039976365,-0.030755263,-0.060143143,0.018828042,-0.057334643,-0.01097569,-0.06666501,0.07244949,-0.049643904,-0.081581645,-0.00032815686,-0.010758636,-0.0052555,-0.052474197,-0.04940613,0.040057994,-0.055080455,-2.6151028e-33,-0.03855461,-0.028192578,0.027122647,-0.0459709,-0.047521953,0.003531689,0.026673177,-0.09659372,-0.011171111,-0.017599892,0.050812945,-0.016299745,0.022950584,-0.05211573,-0.051681496,0.06762753,0.0023385803,0.06422753,0.054444768,0.02670232,-0.030379463,0.12257339,0.09641481,0.060140226,0.019467873,0.061722253,0.05419995,0.038404334,-0.016655449,0.13620782,-0.026910802,-0.07276304,-0.04570131,-0.09494648,-0.05821075,0.03231394,-0.06306667,-0.03149299,0.019564193,0.034016952,-0.009196129,-0.040788725,0.049250487,0.04095086,0.03412649,0.022189341,-0.043728925,0.054294925,0.00077062624,-0.052905723,0.058683354,0.041823145,-0.002738872,-0.03750686,0.048269216,0.07510022,0.014748588,0.05763027,0.124686114,0.008273589,-0.035220183,0.0017469423,0.00707749,-0.07070873,0.00020649865,0.075427555,-0.016124161,-0.0140410215,-0.01632604,-0.056991376,-0.02014051,0.05701416,0.072385535,0.06524715,0.017915703,-0.017927425,-0.07064264,-0.059546083,-0.013453667,-0.06846857,-0.013974508,0.014978864,0.0031536878,-0.094479136,-0.001070319,-0.016510058,0.027751718,0.075517595,0.00045911796,0.00046989747,0.005032961,-0.07722739,-0.0584801,0.007520224,-0.018899957,-2.9915896e-08,0.0021695688,-0.0399848,0.009514176,-0.031892896,-0.07046833,-0.01101582,0.01455688,-0.023895703,0.04283669,-0.021520322,-0.0052409377,0.08561957,-0.008194952,0.0007381692,-0.001609591,0.053748947,0.06642552,0.06953658,-0.065323815,-0.055572808,-0.05050134,-0.022138078,-0.09632125,0.07645348,0.02854556,-0.045619804,-0.0035182766,0.020122722,-0.030699732,-0.022918267,0.080847375,0.0021786042,-0.04672643,-0.08138861,-0.067695044,0.07577166,-0.04631841,-0.036400303,0.04395336,0.00031233463,-0.06196909,0.04620592,-0.05088424,0.03255283,-0.06283926,-0.054034036,-0.013215239,0.0889264,-0.029361403,0.044362683,0.016286988,-0.09547453,-0.0011434247,-0.1145744,-0.020560503,-0.005172469,0.06343393,-0.05514967,0.03031884,0.011260632,-0.074381195,-0.043129038,0.1153634,-0.05738524 +2.4.1.175,"Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli.",384,1.0,-0.10101677,-0.14977033,-0.08975669,-0.006448468,-0.08979734,0.01109585,-0.081542514,0.058187436,0.05944103,-0.036633264,0.02421249,0.08256071,0.002150829,0.02535845,-0.15186448,0.011689165,-0.07877046,0.021184659,0.10164528,-0.06554683,0.07754066,-0.012608995,0.015997544,-0.0029512104,0.018936079,-0.05254318,0.008237016,-0.05890101,-0.036124688,0.0061816666,-0.064584486,-0.046828758,0.03919357,-0.03605925,0.06194542,0.056012932,-0.00846075,-0.027648492,0.053468484,-0.0073029725,0.053551205,-0.031094555,0.013435222,-0.020325579,0.008878569,-0.12917848,-0.052460138,-0.033092164,0.07608788,0.05211757,-0.015081354,-0.025638836,-0.01006709,-0.028790405,0.11294945,-0.059275072,-0.043886382,-0.066100545,0.120604895,0.052587576,0.04424358,0.033357013,-0.012542479,-0.056088015,0.011105788,-0.06331516,0.090615936,-0.0062061166,-0.0098448545,0.0022809017,-0.0700719,0.03110755,-0.031750195,0.047897607,0.010522146,0.07180489,-0.06690878,-0.006702322,-0.027765444,-0.024772814,0.046596225,-0.00761157,0.016142191,0.09373266,0.016885553,-0.022569777,0.048967134,0.042399295,0.010870345,-0.008978735,-0.06361687,-0.021079581,-0.00013510363,-0.05102326,-0.0069735725,0.009127881,-0.013065572,0.057474695,0.02541915,-0.037409995,-0.009448629,-0.022400105,0.07183864,-0.06844843,-0.032463815,-0.035495203,-0.005207626,0.086034864,0.07903819,0.014849005,-0.013714243,0.044789627,0.015454769,0.0068486826,-0.077755004,0.10433224,0.013464915,-0.044011936,-0.072147265,0.0832151,0.01753064,0.027459452,-0.0031677727,0.039825175,0.003119506,-0.023459703,-0.0014213141,4.165218e-33,0.106747605,0.08075681,0.07857374,0.011264457,-0.004768313,-0.0006521073,-0.089454085,-0.020037897,-0.027706128,-0.026392305,0.018575761,-0.031924993,0.01030723,0.04625089,-0.057691045,0.09030371,0.066359974,-0.04515626,0.04620544,0.003161208,0.014595973,0.044253707,-0.044879034,0.003185654,0.05008926,-0.02078836,-0.060084675,0.04763746,0.08381393,-0.00785003,0.051452536,-0.066869274,0.008380976,-0.009559746,0.044739865,-0.02723595,0.01397325,-0.07620837,0.027953442,0.064615645,0.08020199,-0.04168329,0.0005012899,-0.056441944,0.0637062,-0.059940483,0.032253556,-0.004647556,-0.02728811,0.07997889,0.004817819,0.048354156,0.060059432,-0.0013279599,-0.09362716,0.012429189,-0.01075293,-0.09596121,0.044874582,0.079283364,0.04147567,0.02434551,-0.038462352,-0.07002968,-0.020905817,-0.02857012,-0.052113134,0.003317514,-0.034775227,0.06816913,-0.049102947,-0.11973732,-0.047428526,0.024379198,0.013288896,-0.04980692,-0.051556703,0.06037536,0.0036279438,-0.070518404,-0.05316632,0.061780214,-0.0034879185,-0.037501622,-0.04277048,0.059613008,-0.06545298,-0.03767531,-0.0145944,0.052077,-0.060915977,-0.044275284,-0.086531945,0.051535588,-0.04860988,-5.4357177e-33,0.045447044,-0.07684596,0.036348246,-0.045010112,-0.04126593,0.015388801,-0.0016321974,0.027132396,0.022225033,-0.021198839,0.0491133,-0.02013788,0.07507534,-0.08276675,-0.025829569,0.08930541,0.00052029744,0.03420456,-0.044457946,-0.023788124,0.018661147,0.10017858,0.09996717,0.036697693,0.039687615,0.033477977,0.036489945,-0.002110875,0.03794468,0.10616701,-0.05623465,-0.038546126,-0.049128316,-0.08635237,-0.08048052,-0.022823181,-0.011685892,0.006047062,0.010333492,0.0007308451,-0.020689284,0.04486641,0.06548436,0.04894917,0.07642181,0.086769946,0.03157272,0.046983227,0.033803225,-0.027009198,0.04528765,0.0080382,-0.02261565,0.023996454,0.04859143,0.07391039,0.030405056,0.028830985,0.046495717,-0.030166134,-0.06572667,0.008156696,0.030005913,-0.040184498,0.0528087,0.109533355,-0.026523013,0.01844919,-1.7236129e-05,-0.035821557,-0.014241358,0.020391092,-0.018152865,-0.0012140662,0.006420579,0.0127271,-0.12776512,-0.034242045,-0.013140433,-0.006901046,-0.029232798,-0.009810185,0.007721358,-0.06707667,-0.016928034,-0.026300296,0.0144092245,0.107954636,0.057205185,0.060489833,-0.035813507,-0.0041478127,-0.07111577,-0.011720447,-0.0066053863,-3.9939675e-08,0.041214544,-0.018321184,-0.015821964,-0.003778147,-0.046837095,-0.060635176,-0.010602704,0.012897808,0.038896482,0.0035737406,-0.04913925,0.035360433,-0.010094599,-0.007640097,-0.019823683,0.103595756,0.030311354,0.021612791,-0.035957538,0.02903611,-0.04447155,0.0044618826,-0.028550778,0.13845196,-0.0026015148,-0.08850381,-0.01294555,0.013774402,-0.07338093,-0.07951516,0.009343799,0.035505123,-0.10019337,-0.084577,-0.06307705,-0.026137218,-0.009369573,-0.044210162,0.056584034,0.040099073,0.028754957,0.004200655,-0.025021922,0.036614716,-0.019252062,0.015544081,-0.0010157264,0.03448855,-0.03376384,0.0093406495,-0.008891622,-0.06048044,-0.036942445,-0.039109632,-0.034308214,-0.022779092,0.055502325,-0.066293575,0.04994439,-0.0072527505,-0.06472821,-0.06642491,0.19095996,-0.02307931 +2.4.1.176,Acts on the plant hormone gibberellin GA3 and related compounds.,384,0.99999994,-0.11569189,-0.054796208,-0.045329828,0.03563984,0.08531251,0.033614483,0.07481475,-0.021159172,0.021819256,0.03138078,0.108935624,0.03168408,-0.09445115,0.0005644016,-0.009013752,0.026707202,-0.037636273,0.0654015,0.016869694,-0.024554743,0.03957679,0.017727477,0.042469304,0.05690741,0.017405272,-0.007841639,-0.003951264,0.02960955,-0.0110994745,-0.056800075,0.0016080827,0.029352302,0.07223578,0.0042617656,-0.033207074,0.078179926,-0.026099415,-0.08867286,0.06337296,0.040661484,0.04001145,-0.05016381,0.007566387,-0.0071230507,0.028549356,0.030612482,-0.039777275,0.010164524,0.038557146,0.005275809,0.0019359274,-0.10528842,0.054302543,0.045110155,-0.017752884,0.012979058,-0.0629138,0.07306605,0.003906433,0.04757417,-0.04616288,0.013235811,-0.017916314,-0.03812165,0.019034004,0.046371084,-0.06689518,0.0069982624,0.046697784,0.026030213,0.082939856,-0.023001991,-0.008319232,-0.022696825,-0.023120468,0.085387506,-0.06512713,0.0011486858,-0.033601515,-0.035711538,0.008401925,0.041048672,0.067661345,0.08463727,-0.044755284,-0.025276098,-0.018320529,0.13476585,-0.06062937,0.070155986,0.06403441,0.010477667,0.007119934,0.06425578,-0.07038785,0.062445864,-0.002464965,-0.07705845,-0.042781416,-0.020921288,0.0053915153,0.04326702,-0.031075547,-0.07007429,-0.029408121,0.051755503,-0.004674573,-0.015608218,-0.020696256,-0.021578087,-0.07271166,-0.027030582,-0.073757805,0.008077691,-0.08982431,0.084847674,-0.030911358,0.01904147,-0.054677308,-0.0115827685,0.049663734,-0.00070287776,-0.036174927,0.011949217,-0.07799539,0.020790685,-0.07386174,-3.811031e-35,0.076064825,0.027655162,-0.07794767,0.039420318,-0.04058659,0.05031427,-0.06548239,-0.073429234,-0.009451371,-0.028375108,-0.109525315,-0.031699095,-0.006687321,-0.028899323,-0.0058327233,0.038711272,-0.077156425,0.021116529,0.11383577,0.02782129,0.077755354,-0.014727903,-0.118430115,-0.04950933,-0.006063671,0.036455896,-0.03666849,-0.019625556,-0.016448326,-0.042746473,0.12015484,-0.018871846,0.004949829,0.06966837,0.047533847,-0.06468283,-0.004119689,-0.07571558,0.014971906,0.102292925,-0.011725958,-0.026754573,0.058557905,0.012008485,0.06386442,-0.009373078,-0.015169811,0.025547925,0.117171206,0.09360324,0.07651065,-0.014226541,0.07727819,0.08439385,0.009696808,0.022226322,-0.04555521,-0.033909414,-0.004700512,-0.0247886,0.035518285,-0.00443134,0.016577926,-0.09159451,0.031020664,0.08225199,-0.14638011,-0.01711187,-0.04379506,0.08026477,-0.010153079,-0.11957605,0.0052411137,0.01840226,0.017125204,0.0556246,-0.009745736,0.03868875,-0.062977225,0.025054697,-0.05004142,-0.036609,-0.025689123,0.0019549816,-0.0884181,0.024720764,0.0065079117,-0.0018799449,0.018480493,-0.047807433,0.09579509,-0.007461282,-0.03648852,0.005520118,-0.05647495,8.724875e-34,0.055987142,-0.022743635,0.036166206,0.011445127,-0.06680415,0.0052924585,-0.016162137,-0.13525546,0.08971211,0.09008434,-0.008209464,0.015979813,0.028614549,-0.045818016,0.034130953,0.04086612,0.013031166,0.034976263,-0.030136945,-0.054460675,-0.0927474,0.085241914,-0.020995796,-0.007077971,0.025969354,-0.007002855,0.07894154,-0.013946136,0.05503401,0.0633725,-0.03529704,-0.04492171,-0.07301116,0.0065623103,0.07201692,0.013061529,0.035462126,0.0034754185,-0.055202857,-0.06604585,0.009682851,-0.004478423,0.066234425,0.03982423,0.08983195,0.069961816,0.0016756019,0.07421835,-0.052329887,0.074581616,0.02064497,-0.018122468,-0.0009534536,0.011519636,0.04960016,-0.060034767,0.012902155,-0.022619033,-0.056381322,-0.043732,0.06681011,-0.044863418,0.029605698,-0.0053602983,-0.0027136921,0.07001266,-0.013128803,0.07767909,0.078860976,0.050328884,0.033185102,-0.026988229,0.07105548,0.03557096,-0.038752448,0.02865463,-0.06433462,-0.055586472,-0.03401834,-0.07089509,0.030607477,0.011697502,-0.03447692,-0.06295876,0.011339666,0.032277856,-0.044474207,0.096015826,0.07324601,-0.026710194,-0.041151404,0.005915657,-0.04152955,0.07616331,0.024242874,-1.7181529e-08,8.631061e-05,0.006178739,0.028661082,-0.07282251,0.0262971,-0.05501945,0.04523077,0.028140308,-0.007940165,-0.0251865,-0.08345157,0.06294899,0.045818113,-0.034730297,0.055703472,-0.029385293,0.04421507,0.05418399,-0.036627986,-0.023372857,-0.042259417,-0.006351742,-0.075193755,0.019391965,-0.030821564,-0.04705997,0.07386057,0.07107499,0.041095544,-0.011082337,0.11318438,0.011117163,0.016749818,-0.063117124,-0.0018328368,0.043172695,-0.05276685,-0.007571422,0.012153741,-0.035203684,-0.061317127,-0.061619584,0.020895485,-0.003713951,-0.07691968,-0.07163826,0.04628362,-0.030777337,0.04504591,0.079695754,0.02250701,-0.01311416,-0.01210401,0.008351803,-0.054887168,-0.0470414,0.035834264,-0.04101495,0.06874508,-0.060236096,-0.12191669,-0.03040995,0.1132028,-0.01978642 +2.4.1.177,"4-Coumarate, 2-coumarate, benzoate, feruloate and caffeate can also act as acceptors, but more slowly. Involved in the biosynthesis of chlorogenic acid in the root of the sweet potato, Ipomoea batatas. 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+2.4.1.178,"3,4-Dihydroxymandelonitrile can also act as acceptor.",384,0.99999994,-0.025638433,-0.08980824,-0.011616668,-0.04920015,-0.061978936,-0.081099205,0.00084956165,0.0010957522,0.026524553,-0.013947726,0.0879138,-0.037477273,-0.044867206,0.06174977,0.028948983,0.05538098,-0.08394112,0.0030656182,0.009655971,0.09662193,-0.047735605,-0.02685389,0.0065383627,-0.03674487,0.014167484,0.011240295,0.051645443,0.020043703,0.00039762244,-0.058176618,-0.014130117,0.019531364,0.012797946,0.026170952,-0.016279226,0.013325953,-0.07571808,-0.058967073,0.05540087,0.030495021,0.065188505,-0.059864044,0.055630714,0.0148868,-0.035550892,0.006195878,-0.023852706,0.039162185,0.05332149,-0.040644504,-0.029613143,0.022308333,-0.021336982,0.14364569,-0.006800482,-0.011624369,-0.024769172,0.021430759,-0.03818804,0.0032568935,0.01157664,-0.030453319,-0.08982659,-0.037942432,0.048294343,-0.030944888,-0.034517497,-0.06939454,0.004496157,0.0429122,0.059403364,-0.009596369,0.026664777,-0.017850704,0.025397956,0.017550323,-0.009087422,-0.0274016,0.0650295,-0.005345916,-0.01800312,0.058703672,0.062115677,0.05091088,0.06791359,0.011510371,-0.08071156,-0.0071078725,-0.049099345,0.051960275,-0.03661077,0.009481221,-0.037749197,-0.06109857,-0.038952667,0.006718781,0.055038363,-0.006558914,-0.04547745,0.032383867,0.029446846,0.031217666,-0.08734258,-0.049125012,-0.055414293,0.028672403,0.024589792,-0.041834373,-0.06582992,0.015193068,-0.02036952,-0.14447844,0.03941586,-0.012348239,-0.090113945,0.08529957,0.026824577,-0.048330646,0.028431484,-0.09047672,-0.050518468,0.0071971184,0.043408785,-0.024711927,-0.079321414,0.06458776,-0.04986399,1.5847253e-33,0.03173531,0.0573629,-0.0039768107,0.027548954,-0.012343624,0.07677884,-0.09101501,-0.02606632,0.00077950046,-0.14892487,-0.08714005,-0.07584893,0.07839348,0.054411426,-0.05031951,-0.106110804,-0.034324657,0.05431298,0.056346323,-0.049218923,0.01648656,0.04709636,-0.0875822,-0.025191149,-0.040134322,0.020913683,-0.027073283,0.036740042,0.09219323,0.0129273115,0.066660844,0.017337399,-0.040124364,0.023425391,-0.0097807115,0.020903867,-0.0685541,-0.015815847,0.018454505,-0.041390132,-0.04060318,-0.005184567,-0.07350887,0.0076372395,0.06563737,-0.039219566,-0.02891031,-0.03915452,0.014528606,-0.012259872,0.07744145,-0.023817964,0.041649044,-0.067028746,-0.03944322,0.00992136,0.027179224,-0.001198974,0.0035584164,0.04250639,-0.0031129632,0.0947542,0.023007572,0.018462492,-0.022095151,0.053022217,-0.055254612,-0.08163496,-0.04612907,0.07414175,0.008812796,-0.047378592,0.03922634,0.021065066,0.06033675,0.0049889865,-0.010217321,0.02188385,0.02685247,-0.044560477,-0.035171073,-0.010361259,0.0603562,0.060088053,-0.123111114,0.013074616,0.048912976,-0.099675775,0.040420283,0.0008200234,0.06770719,-0.06606172,-0.016949581,0.008062159,0.018562946,-2.8653604e-33,0.03146746,-0.013880806,0.034361936,-0.032300532,0.027494013,0.0783896,0.007446768,0.0008678196,0.086105585,0.029603815,0.15278232,0.01006109,-0.018555053,-0.039712436,0.09932149,0.03947674,-0.02509722,0.009819793,0.0026677065,0.04568011,0.08278419,0.011115949,-0.048100226,0.09128377,0.0014710217,0.01991922,0.045985498,-0.061429754,0.06960604,0.080052465,-0.08746781,0.010277918,-0.011727764,-0.0118965,0.039152402,0.0304102,-0.04055713,0.029016975,-0.07727561,0.022914084,-0.019271111,0.017002268,0.05839421,0.1580082,0.025064167,-0.007820225,0.025564935,-0.00087210594,-0.0794308,-0.02069015,-0.011253262,0.011237294,-0.022612471,0.0013243365,0.05438799,0.121073335,0.04514827,-0.0579131,-0.025899613,-0.032244086,-0.06980244,-0.07452251,0.092349745,0.008586606,0.030490344,-0.0061290357,-0.051593892,0.02088514,0.031028442,-0.03711012,0.056130137,0.004911303,0.049349204,0.05773742,0.049220018,-0.03951842,-0.026607245,-0.055900455,-0.032096926,0.042237256,-0.07050856,0.030989993,0.03486594,-0.018081084,-0.0024090635,-0.16517596,0.07138005,0.051048297,-0.08503634,0.07138879,0.055221632,0.065936156,-0.02037396,0.061270393,0.067603596,-2.6743027e-08,0.054325107,-0.08552821,0.025093462,-0.06583917,-0.06188391,-0.013142772,0.0070452755,-0.01722129,0.04719243,-0.018713074,0.016761947,0.05673495,-0.009445684,-0.03964994,0.066058055,-0.039080676,-0.03313179,-0.06834133,-0.08897988,-0.021346526,-0.068613514,0.0035506794,-0.014806591,-0.03617135,0.032477815,0.044020876,-0.047015097,0.018386241,-0.07745078,-0.0020796089,0.10176829,0.057172846,-0.034075096,-0.046958245,-0.08752497,0.03534406,0.0057316725,-0.020942662,-0.04193114,0.016117707,0.0368683,-0.06048843,-0.08043331,0.05285935,0.030161997,0.019003924,-0.048245825,-0.019017356,-0.026376627,0.030283304,0.010551968,0.013274086,0.06761154,-0.023826223,-0.09554587,0.0125944335,-0.08646467,0.012195783,-0.03245922,-0.059422098,0.020899318,0.017837962,0.15005729,0.060570363 +2.4.1.179,"R may be an oligosaccharide or a glycolipid; lactose can also act as acceptor, but more slowly. Involved in the elongation of oligosaccharide chains, especially in glycolipids.",384,1.0,0.03000922,-0.096587144,-0.114158325,0.035031296,0.015444269,0.005121344,0.0018952927,0.030582068,0.06280909,-0.025682665,0.037057262,0.052983474,-0.06789424,0.04553865,-0.020394042,-0.02564193,-0.01148122,0.029827425,-0.06820197,-0.026461389,0.06171996,-0.002853812,0.0064295256,0.032016203,0.065442346,-0.008962283,-0.019961765,-0.03403397,-0.010558981,-0.09115596,-0.008593234,-0.055660095,0.044271126,0.013070267,-0.019315995,0.034792256,0.022683058,0.003053982,0.073463775,-0.05813598,-0.015396019,-0.03352084,0.09984817,0.033861138,-0.06744227,-0.03833602,-0.03655932,0.07155084,-0.036249638,-0.044672996,-0.044000056,-0.086106844,-0.048181266,0.036939416,0.077053,0.068848185,-0.103619,-0.09293719,0.040895134,-0.019224064,0.03189168,-0.026642064,0.05456134,0.06726726,-0.04768919,-0.03765255,0.03418834,-0.029432986,-0.009595244,0.045093317,-0.024131685,0.028125431,-0.06327929,-0.011325717,0.0414516,0.052878592,0.0038399806,-0.0100985635,0.06615075,0.07948041,-0.035094928,-0.005790973,0.02425444,0.05332092,-0.04404039,-0.061363913,0.099323474,-0.015913036,-0.054775283,-0.024851682,-0.020483904,0.037110113,0.047571573,-0.04333582,-0.069508836,-0.08389072,0.04602768,-0.08030998,-0.013358529,-0.0325125,-0.027348679,0.014971434,0.04938335,0.023176145,-0.12632915,0.05758205,-0.050736677,0.033059716,0.030943474,-0.012692731,-0.03930185,-0.03683376,0.027159909,0.07174471,-0.11699853,0.062364466,-0.036238782,-0.08550264,-0.007286069,0.010745483,-0.057837203,0.04405013,0.004751302,-0.022136925,-0.0058161905,0.038093295,-0.010878959,2.7047884e-33,0.030855399,-0.02961149,0.0430284,-0.065701865,0.048469037,-0.015388553,-0.065711126,0.004137841,-0.029502153,-0.0064919773,-0.039005786,-0.038141724,0.036444463,0.10685261,-0.017448468,0.030934973,-0.013705923,0.025485536,-0.012999225,0.04716516,-0.045152877,0.08759201,0.020702215,-0.0256943,0.030809227,-0.016914995,-0.032716744,0.012273211,0.054128606,0.0125892535,0.12608081,-0.037773296,-0.09729062,0.11811718,0.023661692,-0.004756157,0.03688368,-0.05424174,-0.0065465528,0.0026901525,-0.02352234,-0.0035408442,-0.032963164,0.04481477,-0.0024096847,-0.026876887,0.017320877,-0.011404635,-0.044598736,0.099158496,0.03960431,0.026826745,-0.014102896,0.0020911065,0.018102884,-0.021013016,-0.021319188,0.08639385,-0.011450127,0.045069017,-0.015250741,0.057732727,-0.014756433,-0.05336224,0.023791319,0.06024032,-0.0666893,-0.09502527,0.031538583,0.0615966,0.0036008975,-0.1238271,0.023223875,0.0749208,0.037205353,-0.04692871,-0.025345061,-0.03352873,0.019868355,0.00523744,-0.05744548,-0.055298746,0.0021204206,-0.010395455,-0.12218005,-0.031633962,-0.052619874,-0.09475314,0.01999879,0.03035298,-0.04906289,-0.0056595933,-0.018979311,0.044224102,0.05130075,-4.798936e-33,0.109501764,-0.105366796,0.030971332,0.07227383,0.003899482,-0.012044085,0.0057219933,-0.0011861774,0.079956405,-0.07494346,0.04728623,0.005725748,0.009599889,0.06250714,0.05996445,-0.021648057,0.041402988,0.06777947,-0.020631684,0.05038332,-0.022951612,0.07975303,0.034719277,0.004675459,0.105429366,0.043408908,0.016955564,-0.014725102,-0.059260897,-0.006123504,-0.017518511,0.020021088,-0.045284145,-0.10783431,-0.0650923,0.046471663,-0.06879259,-0.046230935,-0.032448027,-0.023890533,-0.026763478,0.06625586,0.034803372,0.04801917,0.023837904,0.0074154832,-0.049700536,0.08042433,0.0016772163,-0.013019475,-0.071039036,0.04632186,0.038449533,0.038472306,0.09698991,0.07418009,0.03371026,-0.019739231,0.019342748,-0.016887272,-0.04345658,-0.022912215,0.031911835,-0.045023166,0.09079203,-0.03056796,-0.025415014,-0.056695595,0.06673305,-0.019472955,0.088126324,0.013278095,0.018164635,0.089398555,0.03095378,-0.033228435,-0.090281226,-0.095568806,-0.01971381,-0.0403811,-0.021294013,0.057970125,0.072299965,0.00043261028,0.029638879,-0.08197054,0.0028709231,0.051848415,0.031537887,0.08344984,0.016856506,-0.042409077,-0.03603557,0.055086643,0.10653239,-3.46022e-08,0.0821946,-0.07281801,-0.01633538,-0.0667127,0.017847514,0.028903307,0.0015038316,-0.058999106,-0.005892539,-0.0006116251,0.008086568,0.13863952,0.017151484,-0.03708202,-0.039466314,-0.00045798693,-0.020095399,-0.02890427,-0.029497718,0.075134605,-0.14383017,-0.051105488,-0.074217066,0.026052661,0.00024062757,-0.050546367,0.0471451,0.052740976,-0.04152663,-0.05776701,0.04300972,0.073245876,0.10204283,-0.019225497,-0.027447047,0.030763734,0.006688156,0.01102504,-0.057375003,-0.07296301,0.008381998,-0.011039588,-0.012403031,-0.06138768,-0.07270567,-0.0028508236,-0.03512968,0.011367175,-0.054636493,-0.02386082,-0.037649505,-0.051614944,-0.06242304,0.014985144,-0.02707884,-0.055813752,-0.05475796,-0.014736921,-0.021354562,0.0029407847,0.01416457,0.009543875,0.1534051,-0.108452834 +2.4.1.180,Involved in the biosynthesis of common antigen in Enterobacteriaceae.,384,1.0,-0.024020575,-0.015984086,-0.11404109,-0.041310843,-0.08073744,0.053665817,-0.058345817,0.02630675,0.09156757,-0.016022824,0.03161786,-0.105422005,-0.04416396,0.010281222,0.0006540549,0.0070310547,-0.001441543,0.035708196,-0.033378046,-0.042077374,0.0123928245,-0.005653087,-0.085783206,-0.01931943,-0.058258265,-0.027718153,0.029492348,0.00025638318,-0.010536585,-0.06556213,-0.13652067,-0.081724964,0.107234955,-0.03388999,0.058538504,-0.022836857,0.045194406,-0.047787737,0.14491172,-0.014420092,0.05003292,0.00806202,0.008351938,-0.0015440619,-0.023459373,0.027033256,0.056238536,0.113289185,0.011314033,-0.03359407,-0.047844592,0.003938901,-0.03637492,0.024557197,-0.0045007584,-0.0052037705,-0.009804132,-0.034373485,-0.0045147766,-0.015266203,-0.027854392,-0.056977484,0.038948834,0.07485517,-0.048707493,-0.07889158,0.04890991,0.018758126,0.0086736195,-0.07679114,-0.07565646,-0.077968016,-0.0044746436,0.09002175,-0.024418674,0.08370971,-0.00158862,0.0137322135,-0.05619669,0.06251316,0.053517718,0.021602614,-0.048300013,0.060396228,0.050076656,-0.040705953,0.009554489,0.090348326,0.011279122,0.028828014,0.055900533,-0.10320614,0.064644255,-0.08016725,-0.072708085,-0.020227958,0.039324164,-0.07484307,0.060398873,-0.015835864,-0.046160676,-0.004785867,0.08304753,-0.03882524,-0.046344265,-0.036517728,-0.032371495,0.06567371,0.00028235174,0.010230789,-0.022384785,-0.025954485,-0.05248423,-0.0063495017,-0.049971726,0.027885977,0.068833955,-0.08629027,0.014939736,0.058352068,-0.033204187,-0.06472884,0.047394384,0.07890461,0.03771549,0.023558266,-0.038060125,-2.9784582e-33,0.030340575,-0.009810567,0.013791554,0.028309932,-0.039524615,-0.003480149,0.03939189,-0.073595524,-0.018055731,0.05742877,-0.028040959,-0.13138233,0.030929089,0.011574302,-0.007279033,0.09445393,-0.06137387,-0.078980446,-0.055704415,0.027845774,-0.037953604,0.07264817,-0.03927254,0.0024882045,0.02069261,0.070118606,-0.03825388,-0.014989251,0.04797039,-0.026104657,0.04638623,-0.014461582,-0.06988013,0.04856095,0.07219116,-0.0027840615,0.059684243,-0.046308342,0.021435553,-0.029216828,-0.03943149,0.0263678,-0.021837944,0.0049595744,0.06780563,-0.05921963,-0.10732192,-0.04968732,0.039876375,0.020364588,0.06231279,0.001814273,0.080740996,-0.0054702186,-0.04143308,-0.03426233,0.022783497,0.06094644,0.063866265,0.071496755,-0.08864477,0.03818512,0.005333171,0.024017546,0.0059007,-0.019106138,-0.022884512,0.01301718,0.015197729,0.049283504,0.00676874,-0.08723915,-0.041153003,-0.026355067,0.007952003,-0.0009985637,0.0024670076,-0.024163121,0.0529255,-0.0016379585,0.013057553,0.036068566,0.007382263,-0.007087999,-0.061963223,0.036612883,-0.025889192,-0.034771077,0.016581202,-0.008986785,0.13728152,0.06954954,-0.09018631,0.062954284,0.022694893,-1.1271395e-33,0.14074668,-0.089799196,0.016775126,-0.077167004,-0.019984143,0.011325159,-0.049415946,0.026402563,-0.013797674,0.041368555,0.041100785,0.029924337,-0.0041770176,-0.013849962,0.006892027,-0.057623237,0.11288993,0.079872124,-0.04414584,-0.03170992,0.016647449,-0.028830597,0.06586843,-0.11116192,-0.0071294815,-0.0010943268,-0.011780804,0.08528365,-0.050956585,-0.00043028512,-0.009082364,0.019202236,-0.0064044525,-0.023939531,-0.044524185,-0.049714576,0.0029079353,0.030634427,0.078974,-0.027216075,-0.04920578,0.023429427,-0.0034146819,0.061668616,-0.007582078,0.034714065,0.023713332,0.019041974,0.047841575,0.0021598435,0.011894201,-0.032255992,0.03756473,-0.03288506,-0.03005119,-0.013803142,0.01654003,-0.043058377,0.012551552,0.023266088,-0.037165675,-0.024241311,0.036990397,-0.033839226,0.047781456,0.031886607,-0.044480965,0.037987854,0.0631541,-0.011139679,0.015020279,0.02567748,-0.036787346,0.006114469,0.058496643,-0.06173757,-0.09315551,-0.07386892,0.073497675,0.048811425,-0.05220885,-0.06263496,-0.017115254,0.06921529,0.0040905145,-0.119040914,0.015319086,0.01624213,0.011393558,0.057004288,-0.008651843,-0.0034664052,0.04469066,0.047886107,0.026271405,-2.3954046e-08,0.050355833,-0.082472466,-0.007486138,-0.0019738113,-0.019127212,0.031145766,-0.16890843,-0.032025628,0.08000235,0.023189202,0.025902847,-0.0025750669,-0.04785489,0.0057679443,0.02618271,0.0389776,-0.06351347,-0.056873403,-0.03379709,0.053433567,-0.012432646,-0.0071907435,-0.06331721,0.004798014,0.070932426,-0.002924987,-0.039096046,-0.030774975,-0.033849794,-0.04096296,-0.046451807,0.0032986365,-0.021830587,-0.031319782,-0.11093574,0.0126207555,0.03340951,-0.0426518,0.042174164,-0.08139877,0.056392737,-0.01660692,-0.10887697,-0.0054856865,-0.04022502,0.05109919,-0.062662825,0.078418046,-0.078345664,-0.073786855,0.04047063,-0.030682921,0.0321513,0.007516566,-0.06621599,-0.026595054,0.098775,-0.038088158,0.054058205,0.058495667,0.006881857,0.06564865,0.18866041,0.009475106 +2.4.1.181,"A range of anthraquinones and some flavones can act as acceptors; best substrates are emodin, anthrapurpurin, quinizarin, 2,6-dihydroanthraquinone and 1,8-dihydroxyanthraquinone.",384,0.99999994,-0.014190889,-0.08000525,-0.062396593,-0.024587102,0.12332865,0.006725719,0.035738982,0.022813238,0.041224815,-0.08887219,0.0020979084,-0.017137479,-0.06043105,0.07901156,-0.040601104,0.068578824,0.0035522715,0.03165135,-0.009869378,0.023810308,-0.0671306,-0.036264274,0.051860474,0.03729546,-0.009133295,-0.057032455,-0.05706708,0.02980205,-0.016947942,-0.029800165,0.009255337,0.011605836,-0.008242769,-0.000141173,-0.12272701,0.049112212,-0.073615514,0.03533237,0.10741915,0.034905475,0.04048273,-0.031512234,0.046849895,-0.026588222,0.0119968485,-0.04899143,0.021104058,0.038731284,0.052291326,0.031401027,-0.0048251105,0.039198708,-0.08245244,0.10788696,-0.041336767,-0.120860115,-0.07090612,-0.002859394,-0.025311816,0.06629718,0.011397986,-0.033104803,0.013820843,-0.042539902,-0.10588647,-0.05326642,-0.04155146,0.030664176,0.030593688,0.059448987,0.01854338,0.02671759,-0.07048097,0.004428225,0.0015460391,0.13553028,-0.044346903,-0.01717652,0.022405997,0.016537948,-0.043658376,-0.0063801883,0.09267435,0.15041532,0.045053657,-0.038163446,-0.07349617,0.11201783,0.017836705,0.08640747,0.05525816,0.07112615,0.013164467,-0.008389277,-0.046054296,-0.03445265,0.062089473,-0.012256503,0.012271323,0.02160074,-0.049468182,-0.026844513,-0.08082175,-0.06866558,-0.12962218,-0.03581502,-0.032599278,-0.012475398,-0.00980028,-0.11949216,-0.036180433,-0.074181795,0.0418937,-0.01846519,-0.0334462,0.017873334,0.013916113,-0.08238429,-0.032039247,-0.01703427,-0.091785096,0.06459818,0.10482115,0.057366922,-0.011057001,0.0016759177,-0.028817886,4.6342564e-33,0.001333201,0.057426155,0.013851216,0.016504822,0.011180404,0.02768554,-0.056229778,0.018376943,-0.016792875,-0.038934484,-0.05492955,0.004761757,0.021890577,0.050372627,0.024386715,0.007463607,0.0743478,-0.06277639,0.0031595621,-0.07252976,0.037583746,-0.008551774,-0.089687824,-0.02622773,0.013249602,0.022038188,-0.05530659,0.12066037,-0.020488031,-0.017979516,0.011865827,-0.030882938,0.046486285,0.020648083,-0.035643924,0.03511303,-0.08028562,0.012683922,-0.03326351,-0.013953095,0.004568259,0.09346792,0.0048458944,0.028347254,0.0523589,0.049878202,-0.015758786,0.074636705,0.007893138,0.019288683,0.035408385,-0.005900372,0.039886262,-0.03786733,-0.04667893,-0.036121387,-0.0575027,0.031540304,0.008380334,0.050858077,0.014966053,-0.013942964,-0.038627625,0.004687411,-0.08157902,0.04150517,-0.008553832,-0.069395006,-0.03592095,0.07490814,0.00428748,0.036436915,0.012334135,0.03489665,0.036446895,-0.044423275,-0.048676584,-0.0562112,0.045870822,0.07926556,-0.07206887,-0.08292314,-0.03767809,0.042476073,-0.12839937,-0.0069420356,-0.035586774,-0.010348411,0.06951924,0.052878294,-0.016373375,-0.08941731,-0.016498122,-0.0005095111,0.055166867,-4.7137665e-33,0.0504632,-0.06541296,0.050467238,0.022229958,-0.013149725,0.15092821,0.028636249,-0.04797893,0.105238035,0.05495356,0.015702138,-0.00666475,0.029983921,0.008124948,-0.051419716,-0.055696975,-0.0022452318,0.114076085,0.07480986,-0.02091955,-0.044695262,0.08573813,-0.01261774,0.005986016,0.058040548,0.02411306,-0.04873875,-0.0049757687,0.033994544,0.024460632,-0.08570774,-0.01781286,-0.0022197221,-0.047734283,0.017867949,0.055509582,0.010535304,-0.019588914,-0.033664282,0.04893791,0.0685949,-0.01925241,-0.016924288,0.13904217,-0.0086252205,0.06623416,-0.062422503,0.06387941,0.03994213,-0.021960791,-0.021544695,-0.0027199509,-0.022860495,-0.007948844,0.1298105,0.032676913,0.0067393626,-0.046892054,0.02482067,-0.023698423,-0.04269336,-0.07634897,-0.029339379,-0.028128084,-0.02961988,0.06632149,-0.017486067,0.07618567,0.021733,-0.037545275,0.119339645,-0.039027736,0.026337303,0.07249593,-0.0010005027,-0.020746764,-0.005752978,-0.034300942,0.018738216,0.027505115,0.0074776975,-0.015439852,-0.009033807,-0.008465384,0.004084529,0.05814874,0.029795568,0.011090238,-0.04322731,0.042071052,0.012925927,0.04260317,0.026299957,-0.0026185096,0.010044311,-3.686599e-08,0.032730937,-0.08869327,0.04709028,-0.048447315,-0.06985817,0.028494319,0.040069476,0.054359056,-0.07377022,0.009373808,0.019075993,0.06424901,0.053212605,0.0035787616,0.0090853665,-0.061027773,0.07501242,-0.046720833,-0.04332785,-0.00032780695,-0.09498187,0.03170904,-0.030985478,-0.08510672,-0.02375401,-0.07983645,-0.011347452,-0.015957061,-0.005313615,-0.019949384,0.027883302,-0.059917234,0.0021275287,-0.028117305,-0.03539403,0.08152363,-0.076642685,-0.07234139,0.018535683,-0.009524135,-0.0062903357,-0.068863176,-0.07723198,-0.017564094,0.021976672,-0.019113963,-0.009001486,-0.045480426,-0.0315897,-0.030933233,0.0908901,-0.018738935,0.080753565,-0.056679733,-0.055864085,0.0051992433,0.009240687,-0.02067158,-0.0069139823,-0.10075499,-0.005828095,-0.0044079605,0.13415244,0.008004171 +2.4.1.182,"Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria. ",384,1.0,-0.090567395,-0.004658713,-0.16707362,0.01448648,-0.050496686,0.018378993,-0.028677557,0.051734764,0.096958846,-0.028102253,0.10331566,-0.078168556,-0.055666145,-0.0033607704,-0.065809,-0.013025123,-0.024941899,0.012384924,-0.049890827,-0.088704,0.0036558667,0.022914989,-0.044250745,-0.05109408,0.005632504,-0.044426385,-0.008394959,-0.026036162,-0.022247693,-0.07137214,0.020038502,-0.08247029,0.070936136,-0.05642328,0.11928567,0.06554313,0.02619839,-0.033717018,0.119698375,0.022972403,0.020596623,-0.035475854,0.0061463886,0.021938602,-0.0014428138,0.011018368,0.026179068,0.06783565,0.06781554,-0.028979454,0.019900428,0.028369967,-0.045158118,0.040503778,-0.026828721,0.046514306,-0.053086434,-0.0084642535,-0.012326137,0.047766343,0.020523148,-0.021930465,0.099386685,0.056511596,-0.07748945,-0.09467746,0.08562561,-0.0801584,0.011514012,0.038218334,-0.09854181,-0.034615703,0.046077468,0.015107641,0.044314954,0.042974982,-0.024659965,-0.051154096,0.018618803,-0.03911236,0.051354017,-0.08331607,-0.006858211,0.05860255,-0.025478374,-0.17648844,0.032884404,-0.012924856,0.011235765,0.1032221,0.012414369,-0.062784925,0.09709462,-0.010763353,-0.08009547,0.0142059745,0.07545806,0.0263536,-0.023439884,-0.053766873,-0.07469193,0.03539402,0.019703515,-0.013310135,0.013499083,0.010929749,0.005796691,0.06737207,0.019965483,-0.03591167,0.0008957096,-0.014243599,0.04341674,-0.034925442,-0.007444241,0.07205567,-0.035373084,-0.06788901,0.00015902823,0.026998384,-0.046998512,-0.06780691,-0.0028131446,0.05842061,-0.01806374,0.07705643,-0.01857782,8.822458e-34,0.07326647,0.05200973,0.03367801,-0.050179385,-0.017526526,-0.05473899,-0.07755737,-0.044379447,-0.030929718,-0.043332018,0.011744218,-0.13624333,0.056040637,0.09114853,0.018761514,0.042959392,-0.03093633,-0.027601678,0.021651136,0.044612944,-0.036734913,0.014526596,0.029350283,-0.06990516,0.11607059,0.0363394,-0.026738884,-0.004634529,0.017784018,0.038819943,-0.008969732,-0.054230083,-0.06388509,0.05664292,0.07238793,-0.00058760395,-0.039441362,-0.026279708,0.020362087,0.0022404185,-0.01892477,0.07318783,-0.017579952,-0.0315376,0.0047708694,0.049443085,-0.023303,0.054125063,0.071009405,0.0510135,0.019549517,-0.023097921,0.077151164,0.061504126,0.016856207,-0.054809332,-0.094239734,0.017947463,0.01858469,-0.0016437632,0.016370643,0.083345875,-0.08629307,0.00035113288,-0.0068392665,0.041532796,-0.066734895,-0.050599933,-0.006934978,0.0059263385,-0.028419197,-0.020284217,0.08560244,0.052266788,0.015274826,-0.0040142625,-0.0086625125,-1.2707695e-05,-0.027394619,0.028328774,-0.032035153,0.018805468,0.05292883,-0.076446384,-0.039398503,0.012996032,-0.03459479,-0.0042706225,0.047887065,0.020409938,-0.00606213,0.001332852,-0.069932975,0.09921345,-0.04805284,-3.20432e-33,0.062667206,-0.06144853,0.014665012,-0.07407712,-0.08429264,0.07336057,-0.037990995,0.057859007,0.039135497,0.039160077,0.052581344,0.04474976,0.0022355185,-0.04920933,0.0680626,-0.08109608,-0.022399412,0.061867375,-0.009392939,-0.013758957,0.005940217,-0.02601403,-0.018178053,0.029101755,0.028184993,0.010692828,-0.089165516,0.03534953,-0.05936376,-0.011738762,-0.0037999782,0.015512303,-0.04560236,-0.018998522,-0.057136383,-0.036616236,-0.06676094,-0.010428892,0.021989899,0.019495461,0.05228821,0.05726448,0.045727532,0.001064162,0.042046875,0.085914336,-0.018047253,0.04930058,0.005690952,-0.06937383,-0.04016165,0.009666653,0.03391269,0.05521229,0.042043347,0.07127851,0.04960949,0.053178094,0.060395006,-0.068059176,-0.06445682,-0.09814022,0.06391784,-0.055060636,0.051383838,0.045129728,-0.015485998,0.04329714,0.064875685,0.036011424,0.017660188,0.039493073,-0.07241057,-0.00014563845,0.014988097,0.004854405,-0.102865,-0.10528086,-0.01575953,-0.027851127,-0.020979298,0.03260255,0.038171522,-0.060109325,0.025586076,0.034493662,0.03414779,0.054827,-0.026468912,0.06603377,-0.021888945,-0.05435574,-0.086204775,0.03630394,0.03467004,-4.2728576e-08,0.048171293,0.01486511,0.05255709,-0.06100685,0.018952591,0.048415437,0.008331608,0.06993162,0.035306077,-0.029568845,-0.012390573,0.08362964,0.044348396,-0.006092786,-0.052320044,0.081688195,-0.062077202,-0.022136379,0.028487807,-0.003985385,-0.0450972,-0.080047585,-0.077032246,0.10550714,0.010467991,-0.049489953,0.056465514,-0.0014253309,-0.04818065,-0.099411264,-0.0017413959,-0.0092621,-0.03474287,-0.004214439,-0.00328935,-0.05208047,-0.062454417,-0.105633296,-0.036012046,0.07363259,0.036299586,0.04481432,-0.050830714,0.022131335,0.039914005,0.027030854,0.025940573,0.005805232,-0.13635856,-0.04583718,0.0068091713,-0.03909064,-0.055614512,-0.033605397,-0.06024867,-0.060909856,-0.06810051,-0.03138765,0.0017594798,0.018411404,0.018340528,0.033054132,0.100257315,0.0061218007 +2.4.1.183,"A glucan primer is needed to begin the reaction, which brings about elongation of the glucan chains.",384,1.0,-0.085566245,-0.03983473,-0.03410211,-0.02068598,-0.00041667098,-0.051865585,-0.06719178,0.038062632,0.019668836,-0.017975448,0.046828285,0.075178824,-0.0100143375,-0.0033452897,-0.046709456,0.0071229143,-0.034338962,-0.0100288605,-0.06615164,-0.06722111,0.065540776,-0.00032794097,-0.010076803,0.017650863,-0.022754239,-0.031625193,-0.005890492,-0.026695887,0.039939497,-0.09943323,0.027411979,-0.03738627,0.036908362,-0.0012284715,0.024233796,0.034453012,-0.057182018,0.05000135,-0.009605636,-0.002773046,0.08558357,-0.05038021,0.01213288,-0.033996448,-0.03754019,-0.034580976,-0.029666902,0.02418465,-0.023959357,0.047985967,0.062114507,-0.08405832,-0.08921659,0.02118706,0.05426245,-0.050790716,-0.06922075,-0.06712933,0.08062212,-0.026628792,-0.029449806,0.00952785,-0.09181682,-0.032181133,0.0031065806,-0.08147382,0.11774672,-0.045419876,-0.010462036,0.08559305,0.03822931,0.021980148,-0.03416037,0.025040481,0.0042865775,0.007803847,-0.033861585,-0.013292764,0.02296036,0.06622285,0.07029116,0.029531742,0.05178343,0.08959433,-0.02068654,0.044012297,0.011752938,0.0023008422,-0.006885865,-0.04510408,0.044932086,-0.033982947,-0.0745368,0.018679945,0.008015762,0.037101742,0.013093618,-0.076379664,0.060850773,-0.047923062,0.042624395,-0.06874339,0.059282407,-0.052624535,-0.12324318,0.031057449,-0.052307636,0.1343773,0.06584071,0.034661736,0.014791279,-0.009824096,0.08109798,0.020607276,-0.08220898,0.11074039,0.008806485,-0.027191166,-0.038869254,-0.035970915,0.068571,0.059906457,-0.05411811,0.04624003,-0.05170074,-0.009498359,-0.050175652,-2.0503924e-33,0.016423717,-0.006576859,0.013757509,-0.0017272059,-0.06560064,-0.023140639,-0.119747415,-0.058783878,-0.047092393,-0.05291494,-0.055931743,-0.04801147,-0.03225529,0.044447277,-0.08012747,0.012348246,0.049432594,-0.011697143,-0.029185422,-0.022330286,-0.012187144,0.04221079,-0.017309144,0.037577797,0.030569362,0.059484206,-0.015420725,-0.038957335,-0.010391358,-0.04069352,-0.021222025,-0.038207777,-0.08237719,0.094056174,0.043148663,0.023123594,0.012670993,-0.08101783,0.05205468,-0.028174294,0.0075433115,0.055612877,-0.05217928,-0.021649843,0.10955942,-0.047805738,0.03778467,0.03151956,-0.0758387,0.09470332,0.13173448,0.070836134,-0.0017377873,0.010776383,-0.055676125,0.0707081,-0.0010551701,-0.057369884,0.03456029,0.03485622,0.065649346,0.036074642,-0.0021889657,0.040659226,0.03241881,0.07657142,-0.090885624,0.07122625,-0.028644893,0.11661749,-0.03858836,-0.014281496,0.07739576,0.05153496,0.019283265,0.021846926,-0.03866442,0.015729522,-0.0109313065,0.034384686,-0.0013664166,0.006709906,-0.0623857,0.08399627,-0.15272821,-0.027005417,0.018347008,-0.0069544604,0.019649899,0.07185863,0.012082865,-0.04469839,-0.011746259,0.06761278,-0.007848129,-3.679232e-34,0.12399536,-0.11202982,0.083137244,0.059733853,-0.025667636,0.031235958,0.014525502,-0.08735173,-0.0052435943,-0.0054674135,0.026336279,0.08562522,-0.046738524,0.020952005,0.04085009,0.00999324,-0.035997454,0.093766525,-0.03939486,0.019170042,0.014161189,0.060698126,-0.015583507,-0.03208402,0.022781055,-0.0365795,0.03766003,-0.0030867315,0.014677978,0.08336854,-0.025307404,-0.0579685,-0.030616345,-0.061838217,-0.01920508,0.05792467,0.06253147,0.008514911,-0.009646889,-0.046384573,0.0070613343,0.039637826,0.010315077,0.029335687,0.036880612,0.039079137,0.069459364,-0.0075478437,-0.042841695,-0.05801702,0.04561477,0.04787636,-0.028140541,-0.048684835,0.034361456,0.03573281,0.07683384,-0.06294661,0.0029591753,-0.05300697,-0.115705036,-0.030231263,0.000759722,-0.11594901,0.02023652,0.021033457,0.036428,0.040551566,0.022158971,0.07469668,0.08850372,0.052851826,0.04308389,0.009586529,0.046169266,-0.00081766245,-0.045176163,-0.06966581,-0.031529523,-0.065751456,-0.015660988,-0.014636095,0.043199513,-0.056136977,0.05652845,-0.023579523,0.01586078,0.0727623,0.009573587,0.030928666,-0.023153383,-0.020399274,0.0836151,0.07838981,0.004670374,-2.3998355e-08,-0.03744066,0.037779883,-0.03726024,-0.02164566,-0.030295791,0.044041876,0.036867775,0.039429262,-0.031227585,-0.022672603,0.0052854777,0.07896095,0.015994627,-0.007926334,0.0206428,0.009129964,0.016075118,-0.051668923,-0.011268867,-0.06421295,-0.15388384,0.0142377075,-0.054717105,0.030325938,-0.08488653,-0.09989937,0.06648163,0.06657282,0.006303102,-0.054179836,-0.0016229259,0.055315796,-0.046203185,-0.08352653,-0.0058240197,0.000915685,-0.047644556,0.02035233,0.10864747,-0.0264499,0.017398827,0.05623247,-0.008068442,-0.0038173404,-0.084082216,-0.04124954,-0.045955382,-0.05354809,-0.07828093,0.09235245,0.06784035,-0.038608607,-0.014444573,-0.010068652,-0.010890273,-0.04472752,0.010550702,-0.03878358,0.0015327291,-0.067547165,-0.025556063,0.011387647,0.08327843,-0.037465308 +2.4.1.184,"The enzyme converts monogalactosyldiacylglycerol to digalactosyldiacylglycerol, trigalactosyldiacylglycerol and tetragalactosyldiacylglycerol. All residues are connected by beta linkages. The activity is localized to chloroplast envelope membranes, but it does not contribute to net galactolipid synthesis in plants, which is performed by EC 2.4.1.46, monogalactosyldiacylglycerol synthase, and EC 2.4.1.241, digalactosyldiacylglycerol synthase. Note that the beta,beta-digalactosyldiacylglycerol formed by this enzyme is different from the more common alpha,beta-digalactosyldiacylglycerol formed by EC 2.4.1.241. The enzyme provides an important mechanism for the stabilization of the chloroplast membranes during freezing and drought stress.",384,1.0,-0.07031625,-0.04280258,-0.07917971,0.004837623,0.03498057,0.036775593,-0.017773911,0.017140774,0.10181084,-0.024672613,0.023726834,-0.06333694,-0.07486015,-0.0005627336,-0.017784093,-0.029634893,-0.098047405,0.036017157,-0.05957193,-0.06277765,0.09634787,-0.0050308653,-0.080732845,0.010180024,0.015978143,-0.022681138,-0.046561927,-0.052978385,-0.029156407,-0.0740446,-0.0015972708,-0.016465759,0.042036746,-0.059502605,0.066651076,0.054419607,-0.04914119,-0.117967345,-0.0087346025,0.017893305,0.042456776,0.006788695,-0.058053583,-0.004043791,-0.04266096,0.03568776,-0.013868903,0.06386345,0.020758417,-0.03944893,-0.016740808,-0.05869909,-0.05293943,-0.04393182,0.02784552,0.063398734,0.011015231,-0.018468823,0.0036523396,0.058991224,0.03513287,0.072428904,-0.027666025,0.045403197,-0.0758955,-0.04487641,0.010084718,-0.10822695,0.048723377,-0.06000015,-0.13538578,-0.05610364,0.014361872,0.021048771,-0.028192455,0.0024262653,0.052496247,-0.009813771,0.050472498,-0.035959944,0.07805932,-0.03458353,-0.014149793,0.02759207,-0.01869857,0.024138926,0.020254605,-0.0042205863,0.06585135,0.022355955,0.07218294,-0.04457856,-0.010862501,0.012146182,-0.024514496,0.09566511,0.046393514,-0.051285572,0.030838113,-0.062222987,-0.0030799573,-0.017479079,-0.022948913,-0.08800987,0.03766099,0.054621696,-0.015534845,0.033808053,0.032242555,0.020362448,0.024833089,-0.020609636,0.10567907,0.030714564,-0.023355447,0.051757812,-0.05826127,-0.03282968,-0.016312309,0.04988519,0.030941969,-0.057900894,-0.005690662,0.024097746,-0.029391363,0.12836164,-0.08935774,8.0213266e-33,0.079066336,0.07931289,-0.018801136,-0.0004496476,-0.0178799,-0.060060367,-0.07375129,-0.027412567,-0.09138657,-0.049060173,-0.05316644,-0.062073093,-0.043749195,0.016371517,-0.047127005,0.006245517,-0.0062945406,0.030167662,0.025356509,0.048692208,-0.080092706,0.017525412,-0.019283097,-0.012136383,0.080555685,0.04945378,-0.02514903,-0.026969096,0.10958952,0.0049142353,-0.0041450774,-0.07460242,-0.02357913,0.050292093,0.07846895,0.04370193,-0.013090322,-0.0151159065,-0.021549998,0.02263659,0.036262795,0.03477226,-0.017547857,0.0031285433,0.059946984,-0.02961799,-0.10729284,0.09379289,0.06766401,-0.01411483,0.009114596,0.02493036,0.069249,0.00474521,0.015805645,0.009876085,0.003935874,0.021787154,0.027884925,0.009666514,-0.019950956,0.07459681,-0.079211466,-0.044510227,0.10050786,0.06401521,-0.06214541,-0.048514128,-0.042021357,-0.022056554,-0.029743964,-0.008716969,0.056504957,0.06704066,0.041403268,-0.040922865,0.017585136,0.043292478,0.0057056407,0.004264963,0.020816987,0.08016647,0.0780022,-0.07720434,-0.02849489,-0.060299736,0.019530565,0.034680493,0.011535448,0.0454419,0.04186036,-0.020025074,-0.025784744,0.048298627,-0.023685617,-7.380719e-33,0.07789957,-0.07978136,0.03514156,-0.063339666,-0.017861357,0.039603118,-0.06277257,-0.08834449,0.085969836,0.020714173,0.047492076,-0.009043369,-0.014360092,-0.068342105,0.018219503,-0.028403481,0.0049946303,0.09447051,-0.12514637,-0.012145605,-0.004647773,0.05623823,-0.0024639573,0.08927638,0.010004778,-0.045667984,-0.011124026,0.065229736,0.017911263,0.013841541,0.026717145,-0.0314615,-0.088957734,-0.019388627,-0.038595434,0.016507072,-0.056580674,0.05455274,0.055599876,0.09001968,-0.0033980736,0.004592722,0.06091264,-0.048563935,0.07356609,0.083549485,-0.03123042,-0.055577833,-0.0723211,-0.032520626,-0.018164728,-0.026576515,-0.048884086,0.113027886,0.035413705,0.07408316,0.02028584,0.08675733,0.016476002,-0.094579466,-0.015635977,-0.07101092,0.03331365,-0.04026874,0.03463422,0.077068254,-0.0063880715,0.017974602,0.02131173,0.034504186,0.010349686,0.022258846,-0.018604144,-0.009812118,0.0036954444,-0.01561218,-0.111654386,-0.07878899,-0.0054718005,-0.069462,0.0045562824,0.10048604,0.0004516546,-0.032749705,0.014182067,-0.03747939,0.024614245,0.111340016,0.028449439,0.019876085,-0.030091213,-0.021458779,-0.05852402,0.04032162,0.16492343,-4.8854414e-08,0.03603096,-0.0044269445,-0.036975216,-0.06422238,0.0078524975,0.007992479,0.061034847,0.030939752,0.085896835,-0.059472594,-0.06865276,0.08944025,0.046973083,-0.00021392693,0.031005437,0.042167973,0.030928055,0.007679741,0.036412522,-0.002505367,0.016675578,-0.040989988,-0.07703928,0.076714344,-0.031236812,-0.11469411,0.052556504,0.0155902365,-0.040283892,0.045039203,-0.004683017,0.038989358,-0.048859827,-0.049547106,-0.025090795,0.013200921,-0.03700334,-0.03371943,0.03467307,0.12456303,0.028792266,-0.018095998,-0.060173415,0.00889627,-0.03083352,-0.028398572,0.027630275,0.0048940745,-0.0046999473,0.03576231,0.009329628,-0.025319085,-0.04113838,-0.107807666,-0.10548407,-0.042107962,0.01622774,0.022622304,-0.007792796,0.0046053883,-0.02365009,-0.02931608,0.15558603,-0.032452095 +2.4.1.185,Naringenin and hesperetin can act as acceptors. No action on flavones or flavonols.,384,1.0,-0.01390397,-0.052212715,-0.09077948,0.07048991,0.014739099,0.034709677,-0.0060895765,0.000804471,-0.0026634654,-0.09090133,-0.0022191277,0.028986692,-0.046954647,0.029847356,-0.047825042,-0.015153069,-0.0052778595,0.034549557,-0.08398578,0.0654538,-0.013894186,-0.077819414,0.083792135,-0.037517108,0.01466983,-0.026637567,-0.005130687,-0.04516111,0.026586004,-0.08671191,0.11522142,0.049529735,0.03554205,0.020240678,-0.07474181,-0.0088479,-0.027078258,0.0058170813,-0.013566313,-0.024079792,0.08654702,-0.008511964,0.009800732,0.017455032,0.03431886,-0.115416795,-0.09467609,0.023382515,0.011514239,0.05000723,-0.039373662,-0.029466573,-0.033013903,0.004611056,-0.015467814,0.058240734,-0.11451639,-0.061875984,0.019330904,0.021946466,0.08217795,-0.026212016,-0.029407876,0.011330841,-0.030398248,0.074914806,-0.024648286,0.028700143,0.014572146,0.03467139,0.093781374,-0.029306972,-0.0034570787,0.060208272,0.040099863,0.030774817,-0.01985684,0.026653064,-0.033523127,0.0508403,-0.031815227,-0.021504886,0.032739032,0.03594029,0.025628872,-0.0018405226,-0.13471311,0.031173073,0.021167515,0.10903122,-0.009289483,0.046487298,0.07432871,-0.060620785,-0.013385579,-0.035440933,0.012633924,-0.003902446,-0.10127264,0.013633529,0.0073272903,-0.029500118,-0.051825583,-0.0062441113,-0.04689221,0.03605312,-0.00965335,-0.11581959,0.010075602,0.0025431893,-0.023897234,-0.111334,0.06347375,-0.108411215,-0.055797305,0.11584386,-0.052621204,-0.025552463,-0.014007655,-0.0581876,-0.05910045,0.059450854,0.060091473,0.008408749,-3.171956e-06,-0.03414008,-0.031110099,4.3213358e-33,-0.005940805,0.021926697,-0.037074134,0.0458853,0.054179464,0.011312593,0.0073985253,0.009789187,0.051602647,-0.119107425,-0.11862428,0.045094915,-0.030286958,0.014974542,0.03788116,0.023934348,0.048031393,-0.06734562,0.028311608,-0.040684223,0.040848162,-0.02299409,-0.084602125,0.063517004,-0.08571084,-0.07496526,-0.04844713,0.058027487,0.041424584,0.008472056,-0.002562727,0.0060461373,0.049025085,0.081854805,-0.01799882,0.0859308,-0.054570004,-0.019708032,-0.03381902,-0.0096969465,-0.04702353,0.041059494,-0.060173262,0.07458004,-0.009918358,-0.04141146,-0.03531602,0.01573303,0.022289742,0.035287227,0.058439553,0.006862824,0.032407477,0.031149834,-0.010178492,0.077977404,0.030894324,0.08679575,0.035617135,-0.0018038753,0.026489375,0.0056569185,0.023539448,0.0018537546,-0.0370198,0.12939203,0.0071662487,-0.05284653,-0.053751323,0.017356051,0.019860866,0.03657606,0.020996217,0.06425537,0.11824471,-0.04101138,-0.067310065,0.002744977,0.026850097,0.042223025,0.007897213,-0.0698038,-0.017930917,0.11695866,-0.030650482,0.015697729,0.026559057,-0.0045554317,0.06563375,-0.026442865,0.049813423,-0.040296305,0.0020717506,-0.015786218,0.032801874,-4.0100168e-33,-0.0078120492,-0.010530787,-0.0174284,0.10311436,-0.04022675,0.06608699,0.00850124,-0.058458336,0.10060509,-0.031497348,0.07639994,-0.026318582,0.055415545,-0.029696908,-0.06234915,0.011828757,0.033611774,0.08821893,-0.052554622,-0.043401413,-0.11121218,0.0013193004,-0.05357058,0.039344557,0.004702307,-0.0024840692,0.04852602,-0.06502896,-0.017177014,0.056541294,0.023511562,0.02543615,-0.09874687,-0.10719927,-0.0022929267,0.08163591,-0.026346028,-0.025050946,-0.07265624,-0.05780776,0.012538668,-0.038659975,-0.01123287,0.05198299,0.024899764,0.04405723,-0.028837992,0.00036491212,-0.006953884,-0.05643548,0.018290473,0.10154174,0.041096833,0.05694388,0.09268798,0.033834413,0.09868032,-0.0508599,0.022294944,-0.07424922,-0.048921414,-0.04676347,0.010017297,-0.026707523,0.086108305,-0.006279858,-0.03201482,0.12116288,0.057943325,-0.051520444,0.06869693,-0.12000595,0.045995038,0.08399517,0.017955221,-0.02166095,0.00086860755,-0.028828511,0.0005874395,-0.053670723,0.0040002447,-0.035338257,0.03785672,-0.059439294,-0.046354674,-0.048293,-0.0023012185,-0.0398468,0.031226238,0.08224756,0.053801604,0.021283906,-0.020523662,-0.02741636,0.031680744,-2.5625894e-08,0.051755223,-0.04579763,0.04172497,0.035102848,0.049836174,0.028800812,-0.038889382,-0.045248616,-0.037450906,0.04955975,-0.023350948,0.08128682,-0.054358628,-0.03568728,0.002423998,-0.033462692,0.08446153,0.032464366,-0.046222787,0.0045055817,-0.11842847,0.05961104,-0.021589313,-0.07398399,-0.008438347,-0.066340655,-0.015578727,0.020686513,0.10532875,0.016410658,0.009252685,-0.028143356,0.02780369,-0.038018078,-0.12502238,0.011534414,0.025961095,0.01339523,0.027182352,-0.02380803,-0.044669297,0.02342839,-0.03047713,0.01641277,-0.10288471,0.011505956,0.049944464,-0.016996032,-0.008440635,-0.007920726,-0.014489191,0.041448224,0.03196876,-0.028786797,-0.053836808,-0.04713881,0.00088617887,0.021801807,0.028712573,-0.12239819,-0.029951273,-0.04626723,0.065024406,0.04933022 +2.4.1.186,"The first reaction of this enzyme is to catalyse its own glucosylation, normally at Tyr-194 of the protein if this group is free. When Tyr-194 is replaced by Thr or Phe, the enzyme's Mn2+-dependent self-glucosylation activity is lost but its intermolecular transglucosylation ability remains [7]. It continues to glucosylate an existing glucosyl group until a length of about 5--13 residues has been formed. Further lengthening of the glycogen chain is then carried out by EC 2.4.1.11, glycogen (starch) synthase. The enzyme is not highly specific for the donor, using UDP-xylose in addition to UDP-glucose (although not glucosylating or xylosylating a xylosyl group so added). It can also use CDP-glucose and TDP-glucose, but not ADP-glucose or GDP-glucose. Similarly it is not highly specific for the acceptor, using water (i.e. hydrolysing UDP-glucose) among others. Various forms of the enzyme exist, and different forms predominate in different organs. Thus primate liver contains glycogenin-2, of molecular mass 66 kDa, whereas the more widespread form is glycogenin-1, with a molecular mass of 38 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+2.4.1.187,Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls.,384,1.0,0.0061450275,-0.06859975,-0.1231337,-0.014408726,0.0071366145,0.10198822,-0.11325975,0.070248365,0.094672196,-0.051471483,0.06147834,-0.10014791,0.04367516,0.019407168,-0.031109521,-0.05216365,-0.033288524,0.03695586,-0.031947773,-0.045880057,-0.011757466,0.059990026,-0.028831413,-0.022657892,0.015296882,-0.004288498,0.031809572,-0.015981138,0.011603703,-0.035068702,-0.00038522496,-0.035327338,-0.000612043,-0.09339285,0.09011274,0.047347773,-0.02513893,-0.02810541,0.13825873,0.023103224,0.023243016,0.014544362,0.0071288943,-0.009784891,0.01754507,0.07165391,0.032210622,0.045828976,-0.0013524374,-0.015757067,-0.06748637,0.09031189,-0.05203498,0.044038944,0.0051414296,0.089885205,0.05555716,0.02556425,-0.0060252794,0.016222063,-0.010799298,-0.057071567,0.057995267,-0.021706294,-0.071444675,-0.04103768,0.04596382,0.024788264,0.03121957,-0.02178589,-0.03380433,0.020431409,0.08468837,0.049892217,0.0026825035,0.080581084,-0.00035952468,-0.04601986,-0.034681756,-0.011871865,-0.034218427,-0.05274771,-0.084288076,0.04799811,-0.015688298,-0.07831837,0.007630252,-0.019798411,0.06646836,0.094224446,0.062925726,0.03422061,0.0463577,-0.09195124,-0.038985822,-0.014431328,-0.016584994,-0.03990543,0.01823042,-0.10412403,-0.04916725,0.035986345,0.0016216863,-0.036381595,-0.017561909,-0.028547836,-0.0062070303,0.16910511,-0.0004116051,0.02721817,0.08933129,-0.06630442,0.021344326,-0.038674545,-0.0033701079,0.0066923457,0.05880218,-0.16026649,0.0016288249,-0.018785061,0.032204647,-0.005225311,0.025386259,0.04330575,-0.05494461,-0.041660104,9.9413264e-05,-1.7814374e-33,0.11489694,0.029112065,-0.06694263,-0.029537804,0.01767726,-0.013258966,-0.09356396,-0.06807586,0.02839331,0.008187557,-0.105318904,-0.0899519,0.00027005083,-0.0036145353,-0.011961105,0.051697962,-0.04715147,-0.012816681,-0.013883268,0.043838464,-0.0511042,0.10733119,0.033476815,-0.008539812,0.028130574,0.05218639,-0.009385226,-0.05957006,-0.04077928,-0.0139366845,0.026127698,0.012897201,-0.084789835,0.017215732,0.15879652,0.03957106,-0.07565136,0.020262547,0.0038358122,0.002118789,0.021511786,0.07625241,0.037922457,-0.027999908,0.07811534,0.020062145,-0.0045154137,0.03310633,-0.017347893,-0.021538422,0.06470602,0.032032758,0.09646317,0.029039087,-0.053074643,-0.049710833,-0.07179435,0.036447324,-0.016494049,0.057861764,-0.036491986,0.04857562,-0.031804036,0.06789383,-0.039263435,-0.02228771,-0.0635133,-0.0039342768,0.039843116,-0.030476654,-0.0065401336,-0.06626523,0.082859345,0.008344188,-0.046838325,0.0100656,-0.08583995,-0.0114767635,0.042239882,-0.039215103,-0.0138407415,-0.006016476,-0.032510884,-0.027995532,-0.019442119,0.035584357,-0.007695905,0.022115959,-0.040506102,-0.013839895,0.10529931,-0.050724912,0.0101537835,0.08178236,-0.037692565,-1.42877665e-33,0.06808534,-0.08279869,0.055592276,-0.08404459,-0.036900904,0.028809497,-0.0753122,-0.011839163,-0.018778482,0.028770523,0.054128956,0.039081186,-0.021414014,-0.0029668403,-0.00080243626,-0.007006227,0.08686841,0.062308498,-0.038309574,-0.092922926,0.026169566,-0.05213196,-0.021866264,0.0011364372,0.052093104,0.07408534,0.0027761764,-0.006118084,0.040071823,0.023869025,-0.00913637,0.030390382,-0.09359005,-0.03572115,0.04161386,0.07994359,-0.0062827654,-0.007290775,0.07183946,-0.011958664,0.093568824,-0.009608,0.013891502,0.004830444,0.032962233,0.059874292,-0.011689995,-0.08381224,-0.10687952,-0.027865192,0.010709866,-0.017908113,0.0053585027,-0.06453199,0.0032918353,0.019097213,0.009031315,0.07222154,0.021530233,-0.075373664,0.0026885383,-0.10554532,0.022792224,-0.052110452,-0.07496391,0.017358761,0.03537393,0.039993312,0.06185592,0.0065794154,-0.030284982,0.093022935,0.054107916,0.010568627,-0.003768775,-0.032481067,-0.08287288,-0.085596375,0.010547291,0.020408023,-0.047669485,0.014934234,-0.020739537,-0.04884214,0.07283886,-0.061264377,0.02309753,0.088665016,-0.0076537705,0.01207651,-0.026381748,-0.025943156,-0.013422385,0.027119165,0.061603736,-2.3471873e-08,0.06444451,-0.049912866,0.024952173,-0.052703127,-0.019950856,0.016396504,-0.017535111,0.038468104,0.031650305,-0.010448539,0.021077462,0.022150017,-0.041305132,0.048087303,-0.034913316,0.05539493,-0.09786373,-0.10310521,-0.004003595,-0.03277379,-0.07497261,-0.014112399,-0.076841556,0.054650515,0.011684718,-0.052601893,-0.06879787,-0.04973044,-0.033758484,-0.037616137,0.06725627,-0.021240145,-0.042185254,-0.0057831793,0.0008508312,0.006312283,0.0121731935,-0.049339164,3.7955968e-05,0.026831219,-0.0039575887,-0.045072313,-0.10356261,0.05408386,0.085194245,0.046302993,-0.042789772,0.11295906,-0.09157425,-0.03443954,0.016481344,0.008313283,-0.014125901,-0.014253913,-0.060855865,-0.04110575,0.012957516,-0.057188194,0.015713345,0.037208498,-0.035478424,0.056867667,0.062504806,-0.09975228 +2.4.1.189,"The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye).",384,1.0,-0.060742278,-0.07341923,-0.11725999,0.014773628,0.06720421,0.07725726,-0.0360606,0.028280858,0.06764234,-0.008813717,0.073833056,-0.022312962,-0.11521236,-0.08793121,-0.08180988,0.021916403,-0.012713693,0.042856347,-0.05901863,-0.10852253,0.0381812,-0.06812884,0.022146294,-0.022127694,0.0123507995,0.005289423,-0.0070717023,-0.053993534,-0.024982737,-0.07074623,0.042931546,-0.023350412,-0.010827446,0.005366566,-0.0014779817,0.06648224,0.008926794,-0.13739802,0.08297149,0.02264627,0.043506354,-0.050702333,-0.029249199,-0.0055193612,0.019072045,-0.03524799,-0.056925725,0.063022494,-0.014988117,-0.004614748,-0.00083369354,-0.053872753,-0.05494629,-0.0057713743,-0.024809651,0.056323625,0.05719846,0.05075717,-0.024248837,0.106517464,0.049728066,0.00066467543,-0.036135063,0.010234348,-0.023509983,-0.044986088,-0.0464674,-0.007665305,0.070511736,-0.08769075,-0.03422801,-0.086432256,-0.039927423,0.00301104,-0.023815393,0.011674623,-0.027114088,0.025563737,-0.020344794,-0.042186044,0.104765914,-0.02134911,0.04383127,0.05677406,0.08308407,-0.02166079,-0.019820072,0.05515187,0.03194033,0.043485202,0.014624124,-0.046124358,-0.0726742,0.070820116,-0.04734869,0.10744009,-0.007479891,-0.054086935,-0.09089592,-0.08390142,0.0023395596,-0.01657631,-0.014945858,-0.032571405,-0.028605752,0.021138739,-0.009071541,0.001116607,0.0074782344,-0.032891527,-0.015568194,0.046925254,-0.027860213,0.0065823775,0.020309238,0.047379453,0.023304522,-0.0007171406,-0.03541859,0.02329694,0.026952706,0.0859284,0.014687662,0.027908633,-0.060503718,-0.02286584,-0.053159934,2.5622552e-33,0.06195381,0.05436407,-0.061372876,0.01377287,-0.021844413,-0.032132804,0.021000829,-0.0038076942,-0.093997546,-0.041756183,-0.095581345,-0.044061083,0.002882957,-0.006760209,-0.022076547,0.006375746,-0.008644586,-0.08866504,0.07018449,-0.0613743,-0.037194308,0.0060402825,-0.07201862,0.0719353,0.011581687,-0.009200646,-0.0037469934,0.017922455,-0.009049647,-0.005462019,0.02208019,-0.081673145,-0.009527956,0.069279365,0.09336851,0.009720461,-0.0018573581,-0.07523003,-0.025090473,0.07013018,-0.024467045,0.026822323,0.07164847,0.022471352,0.029821431,0.051078126,-0.049301688,0.0823645,0.09837686,0.022893382,0.04658552,-0.023217844,0.118437484,0.07295745,-0.06025781,0.07279068,-0.045184292,0.015780749,-0.0024714388,0.03382435,-0.049368076,0.05967033,-0.030437557,0.01732889,-0.028674684,0.08367792,-0.09350101,-0.018001175,-0.041641254,0.11500503,-0.052616615,-0.075965516,0.04896428,0.033712957,0.105790496,-0.021521663,0.0041475273,0.0128668165,-0.08967705,0.027439103,0.044451423,0.005283393,-0.027556203,0.005576899,-0.094100684,0.016597176,-0.045044385,-0.007893642,0.0575067,0.036345948,0.06589283,0.022552658,0.011061614,0.072869845,-0.04885458,-2.2512745e-33,0.040396545,-0.05397573,-0.010219515,-0.008225318,-0.05412663,0.08529215,-0.039042667,-0.08894687,0.06068236,0.037157316,0.010997065,0.0007857461,-0.012399814,-0.039184816,-0.022801468,0.04360616,0.007841739,0.098399565,0.015270667,0.0038109103,-0.051243298,0.07070163,0.028870026,0.0015244173,0.062302865,-0.031841815,0.067375265,-0.0020336485,0.00444398,0.00079768995,0.009836241,-0.08431162,-0.009543796,-0.028452775,-0.03265831,0.061309543,0.00785679,-0.014715372,-0.014760817,0.09246737,-0.054771505,-0.021641042,0.050057918,0.013344615,0.07794869,0.053419024,-0.06941298,0.03213994,-0.08432207,0.060116854,0.020296423,-0.002734169,-0.018523721,0.07706965,0.048742168,-0.016320985,0.0014337207,0.0017930553,0.023512606,-0.015023549,0.041089743,-0.05161151,0.017757377,0.0069101625,0.10634298,0.043006435,-0.029224763,0.096097335,0.0053279647,0.04151522,0.1175912,0.004491219,0.009991954,0.05338802,-0.034121126,0.0042075277,-0.054722484,-0.032356396,-0.058239456,-0.054746732,0.054993503,0.05287842,0.042038202,-0.090453,-0.054881766,-0.08111144,0.039327208,0.08986099,0.07577599,-0.015062669,0.008875361,0.006547526,-0.0010271787,-0.018250074,0.093214825,-2.9931805e-08,-0.014953182,0.0038594278,0.00050850457,-0.0146653475,0.030216223,-0.03008089,0.11524114,0.009461914,-0.0074054818,0.0050483164,-0.087410636,0.054404944,0.036927886,-0.020029971,0.021055015,0.032174323,0.01175375,0.024227474,0.019727644,0.06577676,0.013990413,-0.0038284874,-0.0953596,0.018127782,-0.014239941,-0.05487789,0.0385304,0.021260135,0.084279515,0.047364328,0.049263317,0.019625576,0.07872272,-0.049340248,-0.15238486,0.04508194,-0.040549032,-0.01297017,-0.024758082,0.016175738,-0.083722636,-0.03896664,0.04802507,0.008980805,-0.04621653,-0.021733362,0.03230661,-0.0015421704,0.0448638,0.029728534,0.0024917014,-0.05023823,0.012596648,-0.0066299024,-0.11259552,-0.07480251,0.020730771,-0.031059219,0.058255244,-0.12200247,-0.06267562,-0.004559122,0.1422543,-0.0052047824 +2.4.1.190,"The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye).",384,1.0,-0.060742278,-0.07341923,-0.11725999,0.014773628,0.06720421,0.07725726,-0.0360606,0.028280858,0.06764234,-0.008813717,0.073833056,-0.022312962,-0.11521236,-0.08793121,-0.08180988,0.021916403,-0.012713693,0.042856347,-0.05901863,-0.10852253,0.0381812,-0.06812884,0.022146294,-0.022127694,0.0123507995,0.005289423,-0.0070717023,-0.053993534,-0.024982737,-0.07074623,0.042931546,-0.023350412,-0.010827446,0.005366566,-0.0014779817,0.06648224,0.008926794,-0.13739802,0.08297149,0.02264627,0.043506354,-0.050702333,-0.029249199,-0.0055193612,0.019072045,-0.03524799,-0.056925725,0.063022494,-0.014988117,-0.004614748,-0.00083369354,-0.053872753,-0.05494629,-0.0057713743,-0.024809651,0.056323625,0.05719846,0.05075717,-0.024248837,0.106517464,0.049728066,0.00066467543,-0.036135063,0.010234348,-0.023509983,-0.044986088,-0.0464674,-0.007665305,0.070511736,-0.08769075,-0.03422801,-0.086432256,-0.039927423,0.00301104,-0.023815393,0.011674623,-0.027114088,0.025563737,-0.020344794,-0.042186044,0.104765914,-0.02134911,0.04383127,0.05677406,0.08308407,-0.02166079,-0.019820072,0.05515187,0.03194033,0.043485202,0.014624124,-0.046124358,-0.0726742,0.070820116,-0.04734869,0.10744009,-0.007479891,-0.054086935,-0.09089592,-0.08390142,0.0023395596,-0.01657631,-0.014945858,-0.032571405,-0.028605752,0.021138739,-0.009071541,0.001116607,0.0074782344,-0.032891527,-0.015568194,0.046925254,-0.027860213,0.0065823775,0.020309238,0.047379453,0.023304522,-0.0007171406,-0.03541859,0.02329694,0.026952706,0.0859284,0.014687662,0.027908633,-0.060503718,-0.02286584,-0.053159934,2.5622552e-33,0.06195381,0.05436407,-0.061372876,0.01377287,-0.021844413,-0.032132804,0.021000829,-0.0038076942,-0.093997546,-0.041756183,-0.095581345,-0.044061083,0.002882957,-0.006760209,-0.022076547,0.006375746,-0.008644586,-0.08866504,0.07018449,-0.0613743,-0.037194308,0.0060402825,-0.07201862,0.0719353,0.011581687,-0.009200646,-0.0037469934,0.017922455,-0.009049647,-0.005462019,0.02208019,-0.081673145,-0.009527956,0.069279365,0.09336851,0.009720461,-0.0018573581,-0.07523003,-0.025090473,0.07013018,-0.024467045,0.026822323,0.07164847,0.022471352,0.029821431,0.051078126,-0.049301688,0.0823645,0.09837686,0.022893382,0.04658552,-0.023217844,0.118437484,0.07295745,-0.06025781,0.07279068,-0.045184292,0.015780749,-0.0024714388,0.03382435,-0.049368076,0.05967033,-0.030437557,0.01732889,-0.028674684,0.08367792,-0.09350101,-0.018001175,-0.041641254,0.11500503,-0.052616615,-0.075965516,0.04896428,0.033712957,0.105790496,-0.021521663,0.0041475273,0.0128668165,-0.08967705,0.027439103,0.044451423,0.005283393,-0.027556203,0.005576899,-0.094100684,0.016597176,-0.045044385,-0.007893642,0.0575067,0.036345948,0.06589283,0.022552658,0.011061614,0.072869845,-0.04885458,-2.2512745e-33,0.040396545,-0.05397573,-0.010219515,-0.008225318,-0.05412663,0.08529215,-0.039042667,-0.08894687,0.06068236,0.037157316,0.010997065,0.0007857461,-0.012399814,-0.039184816,-0.022801468,0.04360616,0.007841739,0.098399565,0.015270667,0.0038109103,-0.051243298,0.07070163,0.028870026,0.0015244173,0.062302865,-0.031841815,0.067375265,-0.0020336485,0.00444398,0.00079768995,0.009836241,-0.08431162,-0.009543796,-0.028452775,-0.03265831,0.061309543,0.00785679,-0.014715372,-0.014760817,0.09246737,-0.054771505,-0.021641042,0.050057918,0.013344615,0.07794869,0.053419024,-0.06941298,0.03213994,-0.08432207,0.060116854,0.020296423,-0.002734169,-0.018523721,0.07706965,0.048742168,-0.016320985,0.0014337207,0.0017930553,0.023512606,-0.015023549,0.041089743,-0.05161151,0.017757377,0.0069101625,0.10634298,0.043006435,-0.029224763,0.096097335,0.0053279647,0.04151522,0.1175912,0.004491219,0.009991954,0.05338802,-0.034121126,0.0042075277,-0.054722484,-0.032356396,-0.058239456,-0.054746732,0.054993503,0.05287842,0.042038202,-0.090453,-0.054881766,-0.08111144,0.039327208,0.08986099,0.07577599,-0.015062669,0.008875361,0.006547526,-0.0010271787,-0.018250074,0.093214825,-2.9931805e-08,-0.014953182,0.0038594278,0.00050850457,-0.0146653475,0.030216223,-0.03008089,0.11524114,0.009461914,-0.0074054818,0.0050483164,-0.087410636,0.054404944,0.036927886,-0.020029971,0.021055015,0.032174323,0.01175375,0.024227474,0.019727644,0.06577676,0.013990413,-0.0038284874,-0.0953596,0.018127782,-0.014239941,-0.05487789,0.0385304,0.021260135,0.084279515,0.047364328,0.049263317,0.019625576,0.07872272,-0.049340248,-0.15238486,0.04508194,-0.040549032,-0.01297017,-0.024758082,0.016175738,-0.083722636,-0.03896664,0.04802507,0.008980805,-0.04621653,-0.021733362,0.03230661,-0.0015421704,0.0448638,0.029728534,0.0024917014,-0.05023823,0.012596648,-0.0066299024,-0.11259552,-0.07480251,0.020730771,-0.031059219,0.058255244,-0.12200247,-0.06267562,-0.004559122,0.1422543,-0.0052047824 +2.4.1.191,"The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye).",384,1.0,-0.060742278,-0.07341923,-0.11725999,0.014773628,0.06720421,0.07725726,-0.0360606,0.028280858,0.06764234,-0.008813717,0.073833056,-0.022312962,-0.11521236,-0.08793121,-0.08180988,0.021916403,-0.012713693,0.042856347,-0.05901863,-0.10852253,0.0381812,-0.06812884,0.022146294,-0.022127694,0.0123507995,0.005289423,-0.0070717023,-0.053993534,-0.024982737,-0.07074623,0.042931546,-0.023350412,-0.010827446,0.005366566,-0.0014779817,0.06648224,0.008926794,-0.13739802,0.08297149,0.02264627,0.043506354,-0.050702333,-0.029249199,-0.0055193612,0.019072045,-0.03524799,-0.056925725,0.063022494,-0.014988117,-0.004614748,-0.00083369354,-0.053872753,-0.05494629,-0.0057713743,-0.024809651,0.056323625,0.05719846,0.05075717,-0.024248837,0.106517464,0.049728066,0.00066467543,-0.036135063,0.010234348,-0.023509983,-0.044986088,-0.0464674,-0.007665305,0.070511736,-0.08769075,-0.03422801,-0.086432256,-0.039927423,0.00301104,-0.023815393,0.011674623,-0.027114088,0.025563737,-0.020344794,-0.042186044,0.104765914,-0.02134911,0.04383127,0.05677406,0.08308407,-0.02166079,-0.019820072,0.05515187,0.03194033,0.043485202,0.014624124,-0.046124358,-0.0726742,0.070820116,-0.04734869,0.10744009,-0.007479891,-0.054086935,-0.09089592,-0.08390142,0.0023395596,-0.01657631,-0.014945858,-0.032571405,-0.028605752,0.021138739,-0.009071541,0.001116607,0.0074782344,-0.032891527,-0.015568194,0.046925254,-0.027860213,0.0065823775,0.020309238,0.047379453,0.023304522,-0.0007171406,-0.03541859,0.02329694,0.026952706,0.0859284,0.014687662,0.027908633,-0.060503718,-0.02286584,-0.053159934,2.5622552e-33,0.06195381,0.05436407,-0.061372876,0.01377287,-0.021844413,-0.032132804,0.021000829,-0.0038076942,-0.093997546,-0.041756183,-0.095581345,-0.044061083,0.002882957,-0.006760209,-0.022076547,0.006375746,-0.008644586,-0.08866504,0.07018449,-0.0613743,-0.037194308,0.0060402825,-0.07201862,0.0719353,0.011581687,-0.009200646,-0.0037469934,0.017922455,-0.009049647,-0.005462019,0.02208019,-0.081673145,-0.009527956,0.069279365,0.09336851,0.009720461,-0.0018573581,-0.07523003,-0.025090473,0.07013018,-0.024467045,0.026822323,0.07164847,0.022471352,0.029821431,0.051078126,-0.049301688,0.0823645,0.09837686,0.022893382,0.04658552,-0.023217844,0.118437484,0.07295745,-0.06025781,0.07279068,-0.045184292,0.015780749,-0.0024714388,0.03382435,-0.049368076,0.05967033,-0.030437557,0.01732889,-0.028674684,0.08367792,-0.09350101,-0.018001175,-0.041641254,0.11500503,-0.052616615,-0.075965516,0.04896428,0.033712957,0.105790496,-0.021521663,0.0041475273,0.0128668165,-0.08967705,0.027439103,0.044451423,0.005283393,-0.027556203,0.005576899,-0.094100684,0.016597176,-0.045044385,-0.007893642,0.0575067,0.036345948,0.06589283,0.022552658,0.011061614,0.072869845,-0.04885458,-2.2512745e-33,0.040396545,-0.05397573,-0.010219515,-0.008225318,-0.05412663,0.08529215,-0.039042667,-0.08894687,0.06068236,0.037157316,0.010997065,0.0007857461,-0.012399814,-0.039184816,-0.022801468,0.04360616,0.007841739,0.098399565,0.015270667,0.0038109103,-0.051243298,0.07070163,0.028870026,0.0015244173,0.062302865,-0.031841815,0.067375265,-0.0020336485,0.00444398,0.00079768995,0.009836241,-0.08431162,-0.009543796,-0.028452775,-0.03265831,0.061309543,0.00785679,-0.014715372,-0.014760817,0.09246737,-0.054771505,-0.021641042,0.050057918,0.013344615,0.07794869,0.053419024,-0.06941298,0.03213994,-0.08432207,0.060116854,0.020296423,-0.002734169,-0.018523721,0.07706965,0.048742168,-0.016320985,0.0014337207,0.0017930553,0.023512606,-0.015023549,0.041089743,-0.05161151,0.017757377,0.0069101625,0.10634298,0.043006435,-0.029224763,0.096097335,0.0053279647,0.04151522,0.1175912,0.004491219,0.009991954,0.05338802,-0.034121126,0.0042075277,-0.054722484,-0.032356396,-0.058239456,-0.054746732,0.054993503,0.05287842,0.042038202,-0.090453,-0.054881766,-0.08111144,0.039327208,0.08986099,0.07577599,-0.015062669,0.008875361,0.006547526,-0.0010271787,-0.018250074,0.093214825,-2.9931805e-08,-0.014953182,0.0038594278,0.00050850457,-0.0146653475,0.030216223,-0.03008089,0.11524114,0.009461914,-0.0074054818,0.0050483164,-0.087410636,0.054404944,0.036927886,-0.020029971,0.021055015,0.032174323,0.01175375,0.024227474,0.019727644,0.06577676,0.013990413,-0.0038284874,-0.0953596,0.018127782,-0.014239941,-0.05487789,0.0385304,0.021260135,0.084279515,0.047364328,0.049263317,0.019625576,0.07872272,-0.049340248,-0.15238486,0.04508194,-0.040549032,-0.01297017,-0.024758082,0.016175738,-0.083722636,-0.03896664,0.04802507,0.008980805,-0.04621653,-0.021733362,0.03230661,-0.0015421704,0.0448638,0.029728534,0.0024917014,-0.05023823,0.012596648,-0.0066299024,-0.11259552,-0.07480251,0.020730771,-0.031059219,0.058255244,-0.12200247,-0.06267562,-0.004559122,0.1422543,-0.0052047824 +2.4.1.192,Some other sapogenins can act as glucosyl acceptors. Involved in the biosynthesis of plant saponins. Not identical with EC 2.4.1.173 (sterol 3beta-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3beta-glucosyltransferase).,384,1.0,-0.06755264,-0.04869617,-0.11447959,0.04208334,0.023692247,0.03264093,-0.050504144,0.026066104,0.08928752,-0.03236641,0.1265056,-0.024325602,-0.14432433,-0.044775553,-0.0160963,-0.07732463,-0.11616199,0.060306177,-0.034669645,-0.029687969,0.05811813,0.026504656,-0.018986428,-0.026279448,0.054928426,-0.08751117,-0.026198162,-0.012243294,0.049515907,-0.03835855,-0.06811878,-0.057970084,0.027361223,0.024306383,-0.052782938,0.041385356,0.010762611,-0.12666233,0.0917098,0.0025472613,0.06514493,-0.01755598,0.0030092862,-0.07229737,-0.020401971,-0.09092408,-0.020993033,-0.03920843,0.008859787,-0.06980405,0.002592247,-0.041850213,-0.014042568,0.01840362,-0.01623383,-0.057655603,-0.031620312,0.021915978,-0.0042331778,-0.006726162,0.014903302,-0.0020248392,-0.010551981,-0.05260255,-0.09755223,-0.027283598,-0.019363359,-0.0058815726,0.037696682,0.019244025,-0.040148802,-0.037147176,-0.026108013,0.072646245,-0.004896274,0.11801706,-0.055387087,0.059937757,-0.016052332,-0.047931697,0.10704136,0.031707127,-0.021869149,0.08942017,0.00071413396,-0.01896481,0.0031647075,0.12611936,-0.0042784764,0.06009938,0.028295837,-0.062174734,0.020764783,0.006362671,-0.029897131,0.06663819,0.05889393,-0.003416719,0.0060550002,-0.018572224,-0.013181631,0.032078493,0.037253182,-0.017455256,-0.05313797,0.07475802,-0.070830256,0.0011331249,0.07021541,-0.07387136,-0.019418195,-0.037994165,0.011601816,0.047965106,-0.10097484,0.05684831,-0.025045518,-0.10985378,-0.02518141,0.032646015,0.047965907,0.005884191,0.046117038,0.06981576,0.017971797,0.04550914,-0.0004682742,4.8875277e-33,0.058224365,0.044631064,-0.022525335,-0.048442125,0.023539264,-0.00682562,-0.11768496,0.018404974,-0.02290525,-0.030153472,-0.15653558,-0.055051506,0.007197239,0.04801618,0.014843428,0.043385856,0.00044596297,-0.00015032367,0.1369127,-0.03301437,0.003481945,0.017318156,-0.08447065,-0.07719613,0.0020807039,0.020210775,-0.026280487,0.014958765,0.043497603,-0.029298248,0.048869878,-0.07118,0.05779507,0.074619964,0.06803646,0.012531563,-0.011757992,-0.071994506,-0.00025675393,0.0071191806,0.049406286,0.0983085,-0.008080788,0.037526075,0.08988368,-0.006308007,-0.08096082,0.0025252989,0.08999465,0.12897272,-0.012096318,0.046530433,0.08712961,0.06761333,0.05327568,0.023160879,0.02310813,0.035246994,0.007024629,0.047434762,0.011377421,0.0403107,-0.023076726,-0.027068688,-0.03407697,0.11365918,-0.10044277,-0.018750325,-0.079593286,0.018121706,0.0032247766,-0.10239436,-0.05690623,0.06912647,0.047898382,0.016943006,-0.0037573422,0.07527561,-0.06101321,0.0065801493,-0.12573558,0.0419291,-0.04308754,0.017485552,-0.10646902,0.07876626,-0.04871231,-0.002272712,0.058976002,0.0034259916,0.012285398,0.030432016,-0.09821911,0.028789802,0.021503547,-5.408733e-33,0.010665396,-0.012159736,0.004949092,-0.0823883,-0.035377312,0.019548023,-0.03352216,-0.06319923,0.03493771,0.037988964,0.06990155,-0.004269653,0.037446868,-0.004140592,0.04595817,-0.026828108,-0.026553305,0.082268216,-0.031044751,0.017628165,0.027197188,0.08247422,-0.0013068604,0.06526797,0.04897714,-0.018737521,0.039026856,0.06437587,-0.049837414,-0.016062723,0.02044677,-0.031864524,-0.06808611,-0.050889507,0.0077885278,-0.027001748,0.006521487,0.012551798,-0.0032607417,0.053343605,0.0096973805,0.04423563,0.0013910383,0.08941403,0.093921445,0.037014466,-0.00023335077,0.01908854,-0.022709811,-0.01592888,-0.04966512,0.021059541,0.018280933,0.034536622,0.056251742,0.013779527,0.091988444,-0.0020790466,-0.01203017,-0.051095456,-0.0004452116,-0.027532365,0.00797235,-0.054577846,0.0504049,0.0029498793,-0.015740434,0.0020028644,0.023832442,-0.0019846614,0.108366966,-0.07316943,-0.005255049,0.048553392,-0.0076775346,-0.017422143,-0.064234726,-0.06561856,-0.034902528,-0.078039445,-0.03771006,0.01953134,0.03446963,-0.06759509,-0.061339617,0.013192486,-0.015850907,0.08440998,0.0065533356,0.055133272,-0.025990257,-0.008418513,-0.0050999247,0.03946189,0.029203322,-3.8103348e-08,-0.028621776,0.01330056,-0.004587801,-0.0066513857,-0.055632465,-0.0023127787,-0.05549271,0.0408071,0.0032436731,0.019403042,-0.05753901,0.10000477,-0.0047441483,-0.033138342,-0.01754727,0.010316724,0.0031933466,0.039355382,-0.010879524,0.004535064,-0.046878718,-0.013290952,-0.06385324,0.01783232,0.0006127238,-0.124525435,0.0045475205,0.059823148,-0.004778531,-0.041273482,0.07683393,0.03757139,0.035076115,-0.013371966,-0.023547525,0.02204085,-0.027217405,-0.013578092,-0.0072855023,-0.0010806487,-0.00030375316,-0.08051312,-0.024132432,-0.004723312,-0.02399658,0.009003497,0.07453794,0.01654162,0.030192666,-0.014079635,0.06023603,-0.09042604,-0.0017815289,-0.041844573,-0.037771743,-0.10951853,-0.0075531197,0.026590534,0.056344762,0.025548559,-0.034740034,-0.023477886,0.1690261,0.014877706 +2.4.1.193,Specific to 5beta-spirostanols. Involved in the biosynthesis of plant saponins. Not identical with EC 2.4.1.173 (sterol 3beta-glucosyltransferase) or EC 2.4.1.192 (nuatigenin 3beta-glucosyltransferase).,384,1.0,-0.06064148,-0.02499809,-0.13313222,0.043174338,0.0469677,0.04825504,-0.06145306,0.044078756,0.08084504,-0.052129343,0.13679175,-0.029720362,-0.12066762,-0.04306105,-0.03412661,-0.03738632,-0.11740956,0.046142448,-0.025009697,-0.021238018,0.08467236,0.07449676,-0.041373167,0.032628328,0.060828537,-0.06112172,-0.041336272,0.042121727,0.012334367,-0.023751738,-0.06565126,-0.0015880961,0.057421204,-0.024803238,-0.033203263,0.094893284,-0.029158825,-0.09463973,0.10234527,0.052172836,0.07366549,-0.025145132,-0.0061372803,-0.05457595,0.005979804,-0.028414011,-0.06031313,0.011792748,-0.02323856,-0.011458921,-0.028203458,-0.049253404,-0.006837315,-0.0013548452,0.015974496,-0.08653647,-0.043155544,0.014084393,-0.028735632,0.035896294,0.05631732,-0.002652553,-0.055403084,-0.026872283,-0.048549604,-0.017425496,0.008563363,-0.08986789,0.04411224,0.0040021166,-0.09284565,-0.065324835,0.018784793,0.103972845,-0.040265996,0.08768958,-0.06551343,0.019947335,-0.05305326,-0.0719046,0.108136244,0.04080231,-0.023249514,0.08320977,0.011168579,-0.028786689,0.0148740625,0.10299966,0.01564317,0.05163281,-0.0013292935,-0.02927158,-0.0039611305,0.0121466,-0.062348604,0.11755381,-0.00027003413,0.0086495485,-0.027369881,0.0009709984,-0.0061261584,0.005403375,-0.036222998,-0.05458117,-0.018023156,0.04759986,-0.041784063,0.008564377,0.0487966,-0.0064796926,-0.02271109,-0.029295618,0.0053653433,-0.0024415222,-0.08737472,0.07038212,-0.023477633,-0.068574,-0.019615239,0.03496112,0.05689464,-0.00027913417,0.038793582,0.03334581,0.012616192,0.053558007,-0.029068856,3.470152e-33,0.110684745,0.027737075,0.0021804706,0.051486675,-0.0034626203,-0.023399103,-0.0783348,0.033853732,0.013157341,-0.04597495,-0.13224632,-0.027811784,0.029579462,-0.043553602,0.0059632827,0.025504293,-0.017803637,0.012746574,0.14033738,-0.010201918,-0.022631492,0.04052759,-0.09620045,-0.04826393,0.018320715,0.022580942,-0.029351229,-0.032210916,0.049621053,-0.026006674,0.0487523,-0.017397694,0.047519036,-0.0026099342,0.112177566,-0.040361915,-0.011240314,-0.050427657,-0.012370493,0.051872127,0.070861846,0.07934136,0.011287313,0.034426846,0.08025471,0.053250417,-0.13194776,0.07537052,0.10878184,0.09999509,-0.004449855,0.034980323,0.109150484,0.09448258,0.04966588,0.0028872006,-0.0305311,0.039763056,0.009077684,0.08240455,-0.023063717,0.06782628,0.0048522213,-0.02977402,-0.04631349,0.05620954,-0.13620614,-0.025175167,-0.037215456,-0.009596917,0.004157417,-0.04649186,0.014571388,0.061953336,0.011793365,0.01343922,0.009006193,0.04024203,-0.07352452,0.033448376,-0.10403264,0.045792263,-0.005579657,-0.021192903,-0.102046,0.040333856,-0.048058353,0.016563129,0.024435222,-0.060037203,-0.011873422,0.010992193,-0.10191825,-0.02543956,0.0053779455,-3.9894662e-33,-0.009900497,-0.029654257,-0.0026839362,-0.083625175,-0.034037855,0.027360018,-0.03265302,-0.10721409,0.032767892,0.08219177,0.069919184,0.0050377175,0.026113806,-0.03678867,0.019785032,0.015613232,-0.04216961,0.0555451,-0.014567244,0.025982488,0.0302156,0.10032481,-0.038268983,0.077673554,0.05658208,0.01965216,0.03569373,0.03719665,-0.006022733,0.003001966,0.04542014,-0.074464865,-0.048020944,-0.0099226395,-0.021940038,-0.019531043,0.0022565837,0.015122728,-0.022701187,0.038906056,0.004421225,0.037669126,0.012994452,0.07520635,0.083247945,0.024059478,-0.008608625,0.010795545,0.0007622452,-0.018869022,-0.011829621,0.009625539,-0.040785674,0.04203825,0.009954577,-0.029632749,0.02829861,0.033920456,-0.02018531,-0.060797017,0.02746944,-0.012662625,-0.014614643,-0.06626703,0.031501234,0.044776466,0.0002950493,0.013719523,0.0022332838,0.0043176105,0.047406886,-0.08081458,-0.006998497,0.033905733,-0.04532096,-0.02604113,-0.017187202,-0.05447043,-0.060693294,-0.023519251,-0.020112995,0.009473143,0.023833154,-0.021268982,-0.06777034,0.023396878,0.027701758,0.037548095,0.06417061,0.03569846,-0.035588734,0.04272776,-0.023908114,0.01237489,0.023989975,-3.4685737e-08,0.07662566,-0.044214096,-0.016787497,0.019702474,-0.06692478,0.01840466,-0.06435816,0.041991554,0.051495895,0.019044671,-0.028865302,0.08448591,-0.012401166,-0.028654173,0.064717144,-0.044822525,-0.012685562,0.09322936,-0.018814713,0.011349626,-0.06654951,-0.0022781172,-0.06800904,-0.032923467,-0.006540632,-0.14621913,0.020003658,0.00039070193,0.00053757,-0.0568322,0.08647647,0.029865084,0.03231274,-0.0030169562,-0.053194806,0.031289387,-0.0640459,0.007950094,-0.03951835,0.064034,-0.06356796,-0.10401121,-0.035423305,0.03497558,-0.045431107,-0.01971505,0.032136317,0.0013241705,0.09346552,0.0025020877,-0.018994479,-0.0201033,0.007161758,-0.043472283,-0.04352631,-0.092515185,-0.017923044,-0.0060502244,0.03323536,-0.00875286,-0.05122918,0.013241761,0.16618495,0.049534366 +2.4.1.195,"The enzyme specifically glucosylates the thiohydroximate functional group. It is involved in the biosynthesis of glucosinolates in cruciferous plants, and acts on aliphatic, aromatic, and indolic substrates.",384,0.99999994,-0.033730377,-0.043692634,-0.09480853,-0.026842413,0.026052266,0.046359174,-0.05690602,0.040249642,0.049547203,-0.0033508032,0.0073843417,-0.02426588,-0.109657325,-0.03476807,-0.027405575,0.026371874,-0.051647406,0.015208309,-0.03577607,-0.11025479,0.07353474,0.044317726,-0.022037897,-0.0053404626,0.035050504,-0.05044182,-0.022194928,-0.047256876,-0.007907014,-0.02782503,-0.070663996,3.981471e-05,0.050576188,-0.0028960768,0.032938898,0.10081946,-0.09585129,-0.06372811,0.09436362,-0.061330386,-0.0111301895,-0.049627084,-0.070319586,-0.01179844,-0.092260875,-0.031059934,0.08228144,0.014112501,-0.039960776,0.074588686,0.002390153,-8.9899244e-05,-0.008410755,0.046161406,0.0014649802,-0.028855132,0.03021271,0.007858546,-0.08126103,0.008803283,0.05235949,0.005477068,-0.07135172,0.01902812,-0.055496052,-0.050009113,0.02810093,-0.032798287,0.010609827,-0.053651735,-0.019240517,-0.07233195,-0.010346005,-0.0030823345,0.05497313,0.040212236,-0.03752439,-0.04159633,0.026572352,-0.06343197,0.12893951,0.08799892,0.09315871,0.08908752,0.053416464,0.027168661,-0.019555327,0.054713935,0.0069685276,-0.031637613,0.049739085,-0.0349711,-0.056612212,-0.018994795,-0.021829406,0.08138192,0.067970715,-0.074591875,0.065517895,-0.062905066,0.03974765,0.03654272,0.03942151,-0.083750114,-0.08076574,0.07774102,-0.09262434,0.07525552,-0.024082173,-0.022076873,-0.024880115,0.028555583,0.045446433,0.015419431,-0.08127588,0.08009448,0.050155185,-0.062286735,-0.010419417,-0.02807587,0.029014558,-0.0060352115,0.040456183,0.11692112,-0.023870343,0.018956613,-0.077067085,1.44347455e-33,0.06095129,0.042733826,-0.008641474,-0.07660338,0.045161087,-0.049928546,-0.047506534,-0.011779771,-0.033822484,0.04398698,-0.07937212,-0.092670046,-0.009478882,0.02833185,0.023677725,0.022047138,-0.081818126,-0.004021036,0.055676475,0.0068179155,-0.023084573,0.07558314,-0.08343467,0.0050700107,-0.07135764,0.097234026,0.007862418,0.07274799,-0.044109333,-0.009497241,-0.008047274,-0.11772469,-0.020438798,0.03183609,0.06788453,-0.0026569187,-0.08610406,-0.009652585,-0.015792677,0.045949467,0.014886703,0.07614861,0.014335462,-0.039033942,0.043490898,-0.036611926,-0.05277687,0.08936275,0.021791922,0.07104529,0.0111010205,-0.05610846,0.12144573,-0.019952174,-0.009837121,0.047503017,-0.0021554218,-0.0037339188,0.027000876,0.05585269,-0.0128514245,-0.02752632,-0.03627104,0.023314666,-0.02968208,-0.028022867,-0.07823696,-0.048601866,-0.013672891,0.13781667,-0.041399706,-0.015914368,0.02177979,0.01398815,0.041613437,-0.044001713,-0.0069690896,0.02945337,-0.034697883,0.05887445,0.056489393,-0.010083115,0.005358148,0.010403985,-0.10937043,-0.031563688,-0.026857527,-0.015639367,0.005950812,0.047571857,-0.0156050455,-0.04750555,-0.024554724,0.08374251,0.02076639,-2.800294e-33,0.09040519,-0.07089463,0.08199292,-0.059799157,-0.05057765,0.045250136,-0.05126836,-0.067771435,0.017524328,0.044247143,0.05076697,0.05622772,0.013605634,0.016905207,-0.0019200837,-0.0417545,0.011719541,0.062480528,-0.033499807,0.04945899,0.011600048,0.05829659,-0.015207325,-0.0049987086,0.048757866,-0.033698764,-0.022028629,0.0569823,0.019717006,0.09954403,0.05199776,-0.015365558,-0.046161987,-0.009433453,0.020493234,0.012885803,-0.02262369,0.03904782,0.0063078897,0.03102801,0.06601454,0.056066915,0.05897292,0.03486804,0.0818332,0.03371492,-0.12817392,-0.06892081,-0.06783256,-0.08031698,0.006905806,0.052686658,0.0060584825,0.024631666,0.08067138,0.061106663,0.03995235,-0.065667994,-0.016768573,-0.076939866,-0.09624254,-0.057037454,0.045009498,-0.019715413,0.02054507,0.01793015,-0.08342508,0.019966176,0.036235984,0.067847595,0.054360382,-0.0058016684,-0.008559535,0.041748546,-0.021154273,-0.045006543,-0.061574012,-0.049779873,-0.045581277,0.016151639,0.07128963,-0.017814834,-0.025557764,-0.028927647,-0.054309424,-0.02955821,-0.02783454,0.16016756,0.0053813616,0.014426803,-0.025239807,0.007844017,-0.056332994,0.048356004,0.047887057,-3.4071245e-08,-0.03213908,-0.0008239442,-0.0071734977,-0.07261107,-0.05833442,-0.0066189417,0.045578253,0.03798994,0.02007876,0.019826343,-0.06956845,0.07929135,0.034893636,-0.028231708,0.021580424,0.038351048,0.007316226,0.004247682,-0.00791842,-0.0007959396,-0.04420247,0.010163896,-0.08040673,0.015903853,-0.0047862735,-0.0437119,0.05271991,-0.013052967,0.024513915,0.012012278,0.013611053,0.056291256,-0.022313436,0.005323518,-0.074472986,0.050267853,-0.054207638,-0.007172725,-0.042327344,0.011248542,0.018760586,0.018229112,-0.07903249,0.030159095,0.0035803814,0.021075584,0.016519636,0.022882491,-0.0085878875,0.056974094,0.01468138,-0.020935766,-0.04681568,-0.04222166,-0.09819447,-0.027451249,0.035876576,-0.01643526,-0.00036165892,-0.07481315,0.008230461,0.06008526,0.21452586,-0.045917418 +2.4.1.197,"The activity of the intersecting mannose residue as acceptor is dependent on two other mannose residues attached by alpha-1,3 and alpha-1,6 links.",384,1.0,0.030605547,-0.044354346,-0.0050938106,-0.057707407,0.06089563,0.01244239,0.099551775,0.004396692,-0.014483702,0.07486217,0.07307664,0.009746445,-0.099238954,0.00014885316,-0.07149897,-0.0030806442,-0.09355955,-0.010858322,-0.01940188,0.07013001,0.0460623,-0.04847647,0.067681104,0.010865644,0.009928766,-0.034297176,-0.01826165,-0.046593677,0.06668582,-0.15637618,-0.04095687,-0.030862639,-0.016400766,-0.017976359,0.08183789,-0.017783044,0.03410193,-0.013817181,0.040124916,0.0022420012,0.04440021,-0.03554893,0.04210412,-0.04345197,-0.07345104,0.0024304693,-0.047242362,0.068458416,-0.008682795,0.002151924,0.026969122,-0.013176365,0.01419369,-0.017617244,-0.053118303,0.06792821,0.0033134131,-0.014366877,-0.027193276,0.051181152,-0.0071757245,-0.011433303,0.009553071,-0.06368924,0.06500591,-0.055829465,0.035788823,-0.08320528,-0.038847566,0.029277753,-0.045808293,-0.026073316,-0.08765949,-0.107005686,0.011589954,0.069469854,-0.010947971,-0.02448024,-0.008421496,-0.0017081529,-0.0120324325,-0.025052723,0.06535138,0.017902195,-0.026541272,0.011833953,-0.08621202,-0.038420387,0.09170447,0.043032978,0.057860605,0.010840766,0.034831,-0.033624552,0.040730685,0.031518683,-0.0124361925,0.062387194,0.07204655,0.031933606,0.049829904,0.03744939,-0.06879083,-0.041587584,-0.018290685,0.083630875,-0.012368451,-0.03375244,-0.02388439,-0.0013982798,0.023541765,-0.06191425,0.08339215,0.016312325,-0.112853,0.036162455,0.070158735,-0.052944567,0.02562082,-0.109676786,0.026636722,0.04401797,0.02428321,0.035661176,-0.08282498,-0.0075033773,-0.06139233,-1.3295787e-33,0.03220882,0.025672274,0.021147082,-0.06395524,0.037047923,-0.01839297,-0.08539048,-0.086785346,-0.09984701,0.01123892,-0.11435634,0.009976675,-0.0057333526,-0.022110729,-0.027641768,-0.0034386814,0.01979063,0.045770645,-0.037406027,-0.035397112,-0.004314158,0.03227835,-0.028797438,0.030503618,0.08767246,0.107239306,-0.0827083,0.030753426,-0.0011377772,-0.01605747,0.13394159,0.063025154,-0.067206964,0.05557394,8.2718456e-05,-0.009535849,0.00023851512,0.022625161,-0.022784479,0.0066421162,0.05125119,0.037011698,-0.003106974,-0.00018833873,0.037365388,-0.07464583,0.0937264,0.08324028,0.021184416,0.010704868,-0.008935576,-0.024750602,-0.03447602,-0.014507056,0.045089666,0.002753076,-0.05320148,0.004259507,0.027549423,0.078735635,0.02576142,0.016945548,-0.056376364,-0.02826759,-0.015618248,0.081581265,-0.0057565635,0.03535245,0.07582797,-0.014245578,-0.068168305,0.018529499,0.068832755,0.025698103,0.046012487,-0.04002131,-0.13170592,0.013963885,0.0048802854,0.0022672422,0.017486641,-0.051884152,-0.008480567,0.00129664,-0.124825194,-0.04071855,0.02418951,-0.09094834,-0.03155349,0.00643388,0.07930488,0.0030149207,-0.05506144,0.013184883,-0.0047129407,-1.1314862e-33,0.11323555,-0.0574161,0.055902302,-0.023846572,-0.07066415,0.001822914,0.11132643,-0.073789865,0.030730093,-0.01910968,0.071010865,0.058132425,-0.034035232,-0.041668396,0.05605826,-0.018204749,0.00996911,0.09283879,-0.02915511,0.00665806,0.0051348507,0.049511056,0.04118995,0.007831596,0.0032327676,-0.012145528,0.038497906,-0.025043316,0.018149268,0.009580614,-0.00963476,0.018857755,0.04568678,-0.09392449,0.037964173,-0.046678483,-0.0405645,0.040395766,0.0037366075,-0.026693404,0.0021088745,-0.026078187,0.027141025,-0.02269067,0.054724965,0.025678694,-0.08952224,0.047787394,-0.1433862,-0.009714854,-0.011815172,-0.07419976,0.062292736,-0.02675303,0.06137452,0.10910083,-0.0013209486,-0.04516154,0.0062260088,0.05287093,0.036956944,0.039420772,0.022689978,0.0036407325,0.045812745,0.0033644477,-0.06392177,-0.04010285,0.055145636,0.016458338,-0.02096855,-0.005324851,0.09891402,-0.0050229286,0.046140723,0.005942678,-0.09233723,-0.05038961,0.036758546,-0.06736004,-0.12591472,0.068755135,-0.008609285,-0.03713298,0.024007132,-0.04384896,0.008427611,0.07818546,-0.008636135,0.046606768,-0.040140897,-0.00411452,0.013223031,0.07168342,0.06290819,-2.6885926e-08,0.10422955,-0.003012938,-0.023113493,-0.09970584,0.011856301,0.053851526,-0.0052469936,0.050983645,-0.043740287,0.00047230715,0.044509962,0.11097359,0.05213033,0.008202729,0.03820301,-0.051545393,-0.023968268,-0.039453052,-0.100441754,-0.014336256,-0.0813739,0.04028737,0.005535139,-0.058432136,-0.03879797,-0.017286446,-0.016529027,0.02527979,-0.09319995,0.01204894,0.051123682,0.019034594,0.021927493,-0.027772034,-0.011408052,0.090070345,-0.06327724,-0.094438426,-0.009920531,0.009744975,0.05810812,-0.11032826,0.021419596,-0.044963304,0.027539115,0.011923058,-0.05386488,0.00507682,-0.04237975,0.088931404,-0.056788094,0.048343893,-0.08308436,0.018385975,-0.020933053,-0.07116605,0.015014245,-0.0058848527,0.0459915,-0.044679277,0.09646894,-0.05029831,0.04355613,-0.06588773 +2.4.1.198,"Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.",384,1.0,-0.028566707,-0.047016103,-0.089474715,-0.015115602,-0.008073875,-0.036655344,-0.044674814,-0.0055730822,0.03778557,0.00021946433,0.040904935,0.050712634,-0.056449167,0.039823793,-0.04669026,-0.04047213,-0.07613067,-0.0049578017,-0.097549446,-0.05447544,0.03336401,-0.060703002,-0.0073774685,0.032352794,-0.04082424,-0.11299936,0.058475006,0.004022548,-0.0063852407,-0.020271804,-0.042026933,-0.041861504,-0.0037411698,-0.03315682,0.0075534023,0.075392775,-0.021783043,-0.037097257,0.07548187,0.0013499209,0.06435849,-0.08541225,-0.006233855,0.0013219782,-0.0057315184,-0.02124361,-0.038412053,0.04335959,0.074351646,0.0034464123,-0.0035374004,-0.019147642,-0.10827413,-0.006347494,-0.069204986,0.053464014,-0.10448474,-0.0047052335,0.0638249,-0.025335554,0.026876638,-0.0025170643,-0.004632282,0.07119721,-0.016551964,-0.052934323,0.06560672,-0.0788641,-0.0033540737,0.048061814,0.0040968517,-0.072385706,-0.05186348,0.0092485715,-0.008125692,0.0691622,-0.02727192,-0.000618728,0.07522658,-0.017902622,0.0488826,0.01536608,0.10139266,0.051048666,-0.0065262984,-0.017396007,0.019472158,0.04051544,-0.019704865,0.021293344,0.016398262,-0.030525267,0.024438426,-0.014751487,0.043672264,-0.016534619,0.045722455,0.01002541,0.013667571,-0.030199116,-0.032424677,-0.03284914,0.07183801,-0.00031933744,-0.08546531,0.022250062,-0.030036053,0.043729357,-0.014158266,0.0346178,-0.0061919326,0.021404538,0.057572782,-0.011921799,-0.02064722,0.052706458,-0.026340375,-0.026228739,0.04733767,0.0014015437,-0.0064027463,0.0365028,0.017149338,0.053958267,-0.053512875,0.05077197,-0.07424588,6.5601778e-34,0.05341968,0.06626546,-0.0503232,-0.019154985,0.026924709,0.021238994,-0.035169274,-0.03343606,-0.07257528,0.025127726,-0.069561735,0.0065750172,4.9017955e-05,0.09141297,-0.0074223564,0.020493638,-0.0054778354,0.05691043,0.00927871,-0.02544266,-0.0046216827,0.021267025,0.0312957,-0.056384582,0.016420817,0.03909021,-0.12849583,-0.06312798,-0.02357687,0.015832331,0.022215122,-0.121243306,-0.14592668,0.04139652,-0.004090735,-0.019523509,0.007769128,-0.10497244,0.100159146,-0.012182541,0.017349971,-0.00028756133,0.013917692,-0.07318141,0.0058296546,0.028404554,-0.10758183,0.053538926,-0.042031817,0.061304335,0.007176273,-0.003660702,0.05613733,0.026347788,-0.11674121,0.03636226,-0.02724879,-0.04042765,0.021737965,0.03804418,0.023434816,0.14354229,-0.0067698793,0.034152318,0.041922446,0.019397277,-0.09031443,-0.03376908,-0.018737914,0.09998278,-0.0009190977,-0.03972502,0.029851558,0.014181771,0.011656064,-0.043077916,-0.0027201865,0.035948303,-0.08087746,0.084531546,-0.020464927,0.04483507,-0.03326323,-0.027959451,-0.056053963,0.014547807,-0.0032317536,-0.08880044,-0.032936122,-0.023490885,-0.015880069,-0.058770362,-0.012990116,0.062535174,0.0079996595,-4.5794835e-33,0.1263221,-0.121022336,0.16641559,-0.09130542,-0.06190788,0.068087325,0.04236488,-0.06562995,0.09548086,0.046709508,0.073296994,0.06900207,-0.02472338,0.010358737,0.045294255,-0.02921065,-0.013049672,0.038484,0.03288838,-0.06664139,-0.061647415,0.0125308335,-0.038301878,0.12591259,0.10293606,-0.083982386,0.010094932,0.011446989,-0.019672392,0.040730756,0.003639928,0.040680796,-0.06590205,-0.027852587,-0.0019594524,0.03651604,-0.069078974,0.025993735,0.017457297,0.020207958,0.05405987,0.0028098756,0.10004049,0.015957734,0.06365714,0.07506816,-0.008975984,0.055722587,-0.07532945,-0.022733426,-0.01399265,0.020048229,0.028252626,0.024963787,0.03734762,0.11516543,0.042162895,-0.00026699033,-0.033084553,-0.11060173,-0.02284389,-0.061044272,0.03563916,0.04401278,0.0009060559,0.03311039,-0.0068117483,-0.07430386,0.04753688,0.035441622,0.045874137,0.019283377,-0.003809123,0.03296641,-0.0007744213,0.04151724,-0.04560242,-0.06157593,0.010595602,-0.0883489,0.041564852,-0.033136874,0.026656779,-0.07097294,0.047177065,-0.11325072,0.019902727,0.18417543,0.022859726,0.035242356,0.021768555,-0.060878977,-0.048913114,0.01624909,0.0073296092,-4.786043e-08,0.06829231,0.0011913828,-0.00056109956,-0.05975479,-0.076339364,0.03785349,0.027668342,-0.020703916,0.05196993,-0.013643287,-0.028179068,0.017663779,-0.031911615,0.0024875514,-0.038589258,0.08465794,-0.09029765,0.04924293,0.039772384,0.0014315101,-0.059380632,0.0003943899,-0.05797252,0.04122188,-0.03053922,-0.032683197,0.049518064,0.011189917,-0.050199207,-0.024342358,0.035844646,0.058874,-0.03462462,0.003162979,0.005619381,0.00040162084,-0.0068994123,-0.0005565401,0.006850956,-0.032543097,0.010437987,-0.0051645115,0.028460264,-0.058380067,-0.015285972,0.017589083,-0.0011178947,0.009512599,-0.025663216,-0.0042612287,-0.04433644,0.04497305,-0.053215954,-0.05103776,-0.076675944,-0.023626447,-0.1050939,-0.07499312,0.003072513,-0.034468465,-0.0143062575,0.0696198,0.13859494,-0.108094014 +2.4.1.199,Involved in the formation of mannooligosaccharides in the membrane of Mycobacterium smegmatis.,384,1.0,-0.010315499,-0.08394423,-0.027679402,-0.023334224,-0.03400953,0.015995862,0.01941129,0.054421093,0.015030943,0.055981647,-0.0036067648,-0.061239757,0.050116796,0.013706006,-0.054885846,-0.009040204,-0.017299077,0.011969463,-0.031174816,-0.017480731,0.07201607,-0.04112652,-0.018847456,-0.0975366,0.06026276,-0.0039631412,-0.053728282,-0.07609135,-0.05256676,-0.05472782,-0.012206834,-0.073765576,0.025625082,-0.06751999,0.13676424,-0.00076176744,0.0016301404,0.010165548,0.100536,-0.08225208,0.010018731,-0.02567242,0.0073569575,-0.0051071276,-0.0876283,0.031895004,-0.05144351,0.06523827,0.008871245,0.022485364,-0.11287023,0.00037382598,-0.014001744,0.0003411012,0.0022339826,0.030847987,0.0054195374,-0.06096849,0.048726454,-0.016475935,-0.028415065,-0.026663244,0.07851713,-0.0072698523,-0.03935254,-0.09545946,0.0043014106,0.0073100934,0.08746738,0.10091564,-0.04729964,0.027443703,-0.021601938,0.028997004,0.1137963,-0.015381873,0.0096803075,-0.07450229,0.019993784,0.08605788,-0.06491817,0.019286942,0.012184186,-0.011339589,-0.045332618,-0.056921747,0.11385548,-0.047528096,0.041463003,0.055779323,-0.009767225,-0.008983078,0.009836031,-0.025399964,-0.05814606,-0.047144443,0.020420693,0.050908845,0.026263017,-0.040427174,0.030678337,-0.077812,0.0654046,-0.06033338,0.0037726946,-0.0024258331,-0.07508391,-0.003564502,0.005976154,0.0027665314,0.035258044,0.031855233,-0.0074676834,-0.019610468,-0.014276299,0.008447144,0.11368368,-0.006211285,-0.03073233,0.017859735,-0.021942707,-0.01974211,0.0036733116,-0.015786408,-0.06471715,0.0059663723,-0.056960244,-1.8770386e-33,-0.0055044424,-0.1163409,0.0569184,-0.0029852663,0.059155162,-0.05280598,-0.054800447,-0.0075042276,-0.04280124,-0.0052072476,-0.0907675,-0.092434816,-0.027266787,0.074770935,-0.14257692,0.06326902,-0.05500866,-0.028027376,0.0066403127,0.043344446,-0.0004382227,0.020331377,0.098311625,0.014839866,0.063434795,-0.022289515,-0.032624982,0.013845897,0.07506732,0.011823111,0.13037054,-0.0636261,-0.06909026,-0.0322145,0.03194215,0.081729434,-0.036771797,-0.0021668975,0.04854883,0.027351273,-0.018666722,0.023029257,-0.0065992353,-0.044343725,0.036865,0.019752407,-0.0046660523,0.05338877,-0.028872538,0.0034866047,0.043805756,-0.085903466,0.03103196,0.01769264,0.03023478,-0.024443299,0.0028833875,0.033592965,0.007963583,0.06406742,0.01134303,0.02492829,-0.017778924,0.05374985,0.0403571,-0.019033305,0.009963842,0.114469215,0.03826292,-0.044754464,-0.073594496,0.0019256118,-0.056924976,0.028183373,0.06861349,-0.09813087,-0.07620716,-0.01467114,0.0021368333,0.02133242,0.11651482,0.031843092,-0.03946823,-0.028563047,-0.07931551,-0.032875467,-0.102138974,-0.03590513,0.006909054,-0.030198576,0.0066391495,-0.05954206,-0.11193569,0.09483242,-0.097438395,-2.44509e-33,0.07743075,-0.10021593,0.13782823,0.04109061,-0.043973625,-0.015030667,0.0734457,0.069963634,0.037889607,0.032167524,0.059912667,0.025778402,-0.02696621,0.01969255,-0.008471025,-0.041766506,0.018334335,0.026172878,-0.033975527,0.023119934,-0.13840772,0.054271773,0.05135503,-0.048545387,0.0005076353,-0.036620826,-0.040379334,0.04779714,0.021312283,0.06450074,0.024630362,0.020668544,-0.028741509,-0.09764567,-0.04211115,-0.09329124,-0.053784356,-0.003490434,0.061540723,0.0065478,-0.014017119,0.04056407,0.04722565,-0.034871,-0.009657447,0.0073380694,-0.056063626,0.016377471,-0.074552186,-0.009305256,-0.032098822,-0.07068363,0.060510375,-0.008194976,0.020923123,0.046265468,0.02558033,0.019128744,0.037946828,0.0069254725,-0.068769045,-0.034553394,0.06941965,-0.023291977,0.04635246,0.10874473,-0.023868434,0.039203275,0.07228275,-0.08486979,0.0077570975,0.07187411,-0.045696326,-0.03133707,0.024375305,-0.0007010828,-0.124899566,0.053062525,-0.016454872,0.018812232,-0.026561541,-0.01872013,0.029962316,-0.08653516,0.070703425,0.009070499,0.060162492,0.05461253,-0.0110049015,0.08049625,-0.016585073,0.040516235,-0.018342873,0.07990146,0.0002811397,-2.1429452e-08,0.04270747,-0.00037583848,0.019768722,-0.031431288,-0.0027795238,0.05214311,-0.018812124,-8.7175984e-05,0.0027869267,0.04792552,0.017557712,0.0641894,-0.0020285095,-0.043701787,0.018350769,0.012421041,-0.04965271,-0.0928596,0.021505993,-0.0034151152,-0.07460583,-0.012866848,-0.008231943,0.12859371,0.047795672,-0.0054845433,0.045819018,-0.029630434,-0.0466438,-0.011697248,0.03461323,0.021244429,-0.03147661,-0.075530335,-0.06459239,-0.019914005,-0.06843296,-0.11162284,0.094127454,0.011867142,0.08879183,0.045242384,-0.010509349,-0.053664736,-0.017577201,0.057099827,-0.054203585,0.054605518,-0.07104328,0.022176746,-0.01845055,0.046640567,-0.09990821,0.054011717,-0.046413958,0.024532253,0.0063427733,-0.0057852715,-0.003940381,-0.01847115,0.00014945104,-0.01144766,0.04525504,-0.014707777 +2.4.1.201,"Requires a high concentration of Mn2+ for maximal activity. The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus. It transfers GlcNAc in beta1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by beta linkages. No homologous enzyme appears to exist in mammals.",384,1.0,-0.020984624,-0.07059274,-0.074836634,-0.0013710696,0.017738815,0.0059846207,0.013189103,0.032796353,0.05559732,0.02700051,0.060228314,0.04796229,-0.028370533,0.060533628,-0.06446794,-0.039940145,-0.056522198,-0.04455844,-0.023113618,-0.050255004,0.0985406,-0.0063651144,-0.0018337575,-0.07045352,0.015771585,-0.045190066,-0.024323644,-0.08319953,0.055416033,-0.05633224,-0.074853465,-0.046198186,0.04865123,-0.04200749,0.031936623,0.08384784,0.027305307,-0.004120052,-0.034347177,-0.018493615,0.0030313244,-0.04197089,0.036415536,-0.032809954,-0.041993216,-0.0016212706,0.026590994,-0.05476278,-0.025780387,0.067057006,-0.062497433,-0.07796606,-0.037195772,0.04156741,0.07166566,0.0685993,-0.12578893,-0.016862983,0.010490152,0.061559178,0.019466432,0.035658784,-0.035000622,-0.035675377,0.0468281,-0.040263917,0.02760555,-0.06096554,-0.008004741,0.03304049,0.02865414,-0.032785352,-0.050772645,-0.033105742,-0.013379804,0.007712009,-0.03270902,0.022108033,0.05368641,-0.008541338,0.033668347,-0.021905504,0.09904312,0.07528091,-0.04940197,0.06955547,-0.06302355,0.06058014,0.03753111,-0.004816544,0.045909755,-0.0009200538,-0.042444702,0.02822673,-0.024461059,-0.012300022,-0.0010462801,0.01768413,0.034765407,0.011346254,0.017738985,0.0113554085,0.05628619,-0.090304084,-0.014030133,0.030451858,-0.0019606566,0.06587655,0.03981737,0.004505031,0.021453036,0.091340326,0.027699744,0.063044496,-0.062455542,0.03987315,0.05431934,-0.096238874,-0.09675515,-0.022236403,0.04024659,0.024978625,0.0034002045,0.07262075,-0.018411426,0.05412574,-0.039229818,2.7183434e-33,0.08117375,0.02357076,0.047333278,-0.0077419155,-0.023008462,0.021330079,-0.024825409,-0.0343112,0.022125706,-0.005270766,-0.07152712,-0.05261845,-0.047478046,0.15670769,-0.03546848,0.025557464,-0.007753759,-0.05988661,0.11320103,0.0032073602,0.046844695,0.06227012,-0.012970342,-0.02681746,0.09955516,0.08124419,-0.0036687104,-0.03432561,0.06910461,-0.013690649,0.05090447,-0.16125983,-0.060376894,0.039966326,0.04585726,0.047704812,-0.042322226,-0.02739214,0.0079074595,0.017603517,0.034030907,-0.02379011,-0.06254447,0.047882065,0.04515778,-0.0068711345,-0.032816835,0.06983708,-0.08487278,0.05748976,0.03758266,0.0040690852,-0.004264985,0.02400043,-0.10648014,0.03759342,-0.023758149,-0.018838806,0.005499134,0.09462324,0.029375497,-0.0032177651,0.0031812468,0.040430035,0.07274974,0.0052697486,-0.10008189,-0.08963114,-0.040672775,0.03300356,-0.042579293,-0.12738766,0.06708159,-0.034755975,-0.04072882,-0.07088962,-0.051303446,0.0008001308,0.014886533,-0.016015291,-0.0035063291,-0.025217578,-0.025567876,-0.052590743,-0.08553507,0.032516476,0.018518599,-0.13474865,-0.0019013847,-0.013876122,0.059181407,-0.0010814382,-0.057130583,0.041898105,0.009325546,-4.7821428e-33,0.08443084,-0.11880223,0.08305619,-0.008748506,-0.061388772,0.005971165,0.037223313,-0.08283358,0.01856642,-0.016355235,0.055280667,0.022672394,-0.005685292,-0.011861037,0.020194056,-0.022067536,-0.02630669,0.12611148,0.0612125,0.0031711624,-0.056332815,0.082176715,0.020610094,0.03299098,0.04729779,0.045817003,0.02414134,0.017506123,-0.020817025,0.03232221,-0.028545387,-0.041372865,-0.027683483,-0.118461475,0.014863359,0.019051421,-0.04630252,0.03552936,0.02572414,-0.027825112,0.006964567,0.013443158,0.04722542,0.023286259,0.00019880665,0.08951638,-0.10688361,0.016897291,-0.043119747,-0.04634377,0.0036351765,0.024901299,-0.050033998,-0.019780606,0.051981237,0.07324438,0.029877525,-0.009111241,-0.00010875129,-0.012618658,-0.02459427,-0.043161556,-0.025807055,-0.005723774,0.102490544,0.03755332,-0.016965544,0.007689676,0.024835335,0.03509698,-0.01610187,-0.02228195,0.011739765,0.018184075,-0.050809905,-0.009359445,-0.09185324,-0.059573825,0.010922164,-0.06837956,-0.048932895,0.028431052,0.0088978205,-0.06885107,0.04076956,-0.10953262,0.0848607,0.1697588,0.040175654,0.045022454,-0.03297166,-0.06977909,-0.07531349,0.035543565,0.044084124,-4.2366402e-08,0.0002474354,-0.02297388,-0.02512598,-0.087161064,-0.030984797,0.010758581,0.018475914,0.056048855,0.04548525,0.038851775,-0.046552982,0.033952944,-0.03319719,-0.0055355476,0.025174554,0.05073429,-0.04056391,0.03838882,-0.05951524,-0.064986624,-0.09218978,-0.0069350963,-0.11766211,0.09153303,-0.009626633,-0.051933005,0.044958275,0.121429004,-0.03012082,-0.019927826,-0.0018513458,0.078088515,0.002455048,-0.0686587,-0.025093973,0.0517437,-0.0024217283,-0.019275576,0.017953262,-0.03175074,-0.06378077,0.004283033,0.0024412405,-0.015907073,-0.027069336,-0.03554223,0.03408883,-0.03235821,-0.003358207,0.09663238,0.01765155,-0.0071890824,-0.02659901,-0.0892006,-0.09373127,-0.006177791,-0.03600136,-0.021240145,-0.0020444016,-0.01983209,0.0050432025,-0.016603148,0.11473496,-0.086122036 +2.4.1.202,"The enzyme is involved in the detoxification of the benzoxazinoids DIBOA (2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one) and DIMBOA (2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) which are stored as the respective non-toxic glucosides in the vacuoles in some plants, most commonly from the family of Poaceae (grasses). Benzoxazinoids are known to exhibit antimicrobial, antifeedant, and antiinsecticidal effects and are involved in the interaction of plants with other plants, insects, or microorganisms. +",384,1.0,-0.06819518,0.020657983,-0.11447891,0.007834896,0.046717025,0.049775835,-0.024412462,0.079381905,0.07093285,-0.03606693,0.051313728,0.014330012,-0.032429673,-0.010340366,-0.11521329,0.110010505,0.028269695,0.033732634,-0.056987524,0.033627745,-0.0021901976,0.06485841,0.008688822,-0.01807507,-0.031357955,-0.014137859,-0.06785368,0.035070047,-0.0101308,-0.06788639,0.10727256,0.038418517,0.04394597,0.0040208884,0.055180218,0.040545996,-0.04394543,-0.07242985,0.079045855,0.039656498,0.01373728,0.009686637,-0.05324002,0.009529005,-0.042542394,-0.036434893,0.004675555,0.05035772,0.068649486,-0.021650739,-0.009257116,-0.02497397,-0.01955803,0.10715247,-0.075464845,-0.046392735,-0.021952791,0.023389386,-0.10224964,0.009770836,0.045075584,0.06444605,-0.019879885,0.0045829318,-0.04659826,-0.019588882,0.0068562664,-0.030548688,0.029403707,-0.0774964,-0.09428187,-0.04007993,-0.05441611,-0.041339893,-0.08420474,0.036373977,-0.029696211,0.047268257,0.02907425,-0.06857994,0.05450065,0.013981985,0.036593977,0.09126766,0.021952813,0.0012049899,-0.059967645,0.06339813,0.07388223,-0.01776274,0.05842915,-0.037316445,0.0049563493,0.03581456,-0.05285955,0.04087606,0.051872816,-0.038496513,0.009403532,0.047601316,-0.049253665,-0.019544914,-0.024514552,-0.0786779,-0.0524544,0.04275276,0.013933143,0.04274662,0.028876109,-0.08231193,-0.024882074,0.058795948,-0.016185077,0.0031114432,-0.040301934,0.026394896,0.10322973,-0.053409867,-0.04343663,-0.035960075,0.0058255484,-0.03042973,0.08151973,-0.025068182,-0.06466727,0.016566044,-0.08743409,1.336327e-33,0.04214144,-0.02132033,-0.0068974793,0.020671016,0.008846738,0.020171827,-0.083117664,-0.04442009,0.04269058,-0.007463103,-0.12210088,-0.06391947,0.07472753,-0.001923197,0.002259267,0.06067484,-0.028273614,-0.029243229,0.06339092,-0.04558506,0.05712758,-0.001831532,-0.07117131,0.0027022923,0.0022972985,0.109953694,-0.03565241,0.015079783,-0.050924264,-0.011120562,-0.02361633,-0.03850897,-0.07030817,-0.00071746914,0.04551689,0.03852376,-0.11297625,-0.009806976,-0.0007902105,0.0064862,-0.04259086,-0.05136446,-0.0061402246,-0.010331005,0.104566105,-0.038320396,-0.10845527,0.104044214,0.06304289,0.053074673,0.04244936,-0.0923444,0.04937936,0.015989777,-0.04765239,0.010937764,0.06504898,0.037779603,0.04033988,0.010003858,-0.009230062,0.054517422,-0.069126405,-0.01973018,-0.008919551,-0.052044347,-0.08194126,0.034723997,-0.055561826,0.07692952,-0.038294297,-0.014878014,-0.023334904,0.07232064,0.03142263,-0.082484476,-0.017862288,0.009158812,0.06911636,0.07890663,0.041278876,-0.06884199,0.022426944,-0.06940327,-0.0932209,-0.004872982,-0.030629767,-0.017074157,0.037272103,-0.023057254,0.034395456,0.013801448,-0.007697751,-0.032936785,0.05586135,-3.6978103e-33,0.06902109,0.03135083,0.014490284,-0.05118975,0.060466193,0.06979832,-0.05686547,0.025785511,0.001586689,0.025832554,-0.03876689,0.05226854,-0.038048547,-0.017840724,0.064221494,0.023770235,0.00042122358,0.025854288,-0.021486409,-0.03131319,-0.08474176,0.07698758,-0.009018767,-0.013200063,-0.02137569,-0.05871473,0.014760649,-0.007592709,0.010503097,0.08370329,0.057387374,0.0075015267,-0.046897534,-6.6901855e-05,0.08315156,0.0056678485,-0.06892031,-0.039518252,0.01564746,-0.019146757,-0.041532345,-0.02248105,0.034934558,0.03877883,0.06421759,0.09342403,-0.19337049,-0.06799078,-0.050014593,-0.0019365842,0.02669149,0.06829779,0.017757174,0.05382132,0.07423804,0.033452548,-0.01487747,-0.025312798,0.049467146,-0.01608405,-0.004271335,-0.06231549,-0.013650503,0.053145226,-0.022965983,0.029518083,0.016929353,0.10915856,0.015433225,-0.001150463,0.028229157,0.014703821,-0.038641665,-0.0010334185,-0.12906845,0.011534147,-0.011348692,0.005916239,-0.013573093,-0.028812595,0.016736243,0.019831384,0.04667946,-0.090972535,-0.09539121,-0.03594303,-0.040534582,0.10051964,0.043325428,0.006762959,0.0080053,-0.0040191375,-0.008705472,0.01113181,0.0644118,-4.656269e-08,-0.018825084,-0.054345667,0.029825216,-0.04455365,-0.049416486,-0.046217836,-0.04461017,0.058119632,0.048881553,0.024548372,0.0081847515,0.09441145,-0.039922666,0.017609937,0.016682167,0.020790631,-0.010194998,0.011807298,0.0018978571,0.11528369,-0.033184096,0.03561868,-0.018228227,-9.256548e-05,0.061953906,-0.10515352,0.017431367,-0.021118168,0.029742826,-0.0068997666,0.09000709,0.095422626,0.005208275,-0.00030854743,-0.15076917,0.024486067,0.0028476827,-0.07253555,-0.035263717,0.0042133834,-0.0072754784,-0.0437114,-0.054644126,-0.028321415,0.03044512,-0.03147242,0.032539185,-0.018944992,-0.041827176,0.0123989815,0.008279354,0.03521882,-0.013268856,-0.024702016,-0.12633194,0.003920164,0.029923374,0.017226946,0.0254717,-0.11795707,-0.036948655,0.009671146,0.1433016,0.03884467 +2.4.1.203,"Unlike EC 2.4.1.215, cis-zeatin O-beta-D-glucosyltransferase, UDP-D-xylose can also act as donor (cf. EC 2.4.2.40, zeatin O-beta-D-xylosyltransferase).",384,0.99999994,-0.06429917,-0.011582963,-0.02534046,-0.019876014,0.029335573,-0.036269825,0.020218695,0.09622338,0.048755575,-0.03224487,0.05729556,0.0577316,-0.075084396,0.04309397,0.014397194,0.046448957,0.029747093,0.036056794,-0.0658318,0.05118703,0.03323755,0.022725092,0.097837485,-0.039800312,0.054041106,-0.11288,0.015824638,0.022615204,0.05330192,-0.04200156,-0.013050079,-0.02142502,-0.043064475,-0.049285278,0.08850047,-0.009541238,0.072646946,-0.04077403,-0.0522191,0.0074916985,0.096107155,-0.039176963,-0.040854495,0.07110214,-0.09210859,-0.018080939,-0.034795906,0.024406461,-0.04062933,-0.014017557,0.019035796,-0.07044351,-0.05759879,0.04052372,0.012461233,0.03819069,-0.044336643,-0.055449907,0.0024354835,0.0487061,0.0186626,0.056421824,0.05481784,-0.0082921935,0.0122480765,-0.023257302,0.08055548,-0.019580364,-0.006633573,-0.0071880324,-0.0411132,-0.044940807,-0.04377709,0.029884417,0.030882554,-0.00011754275,0.027114326,-0.022329539,0.053277884,-0.035533052,0.054251254,0.032514203,0.06489444,-0.022373144,-0.0061574597,-0.030799178,-0.025240611,0.10498408,-0.04374231,0.0327488,-0.064184435,-0.02093889,0.036329843,0.005457203,-0.06662537,-0.017165141,0.10164419,0.055385437,0.04932891,-0.008757999,-0.02085252,0.06636534,-0.06351554,-0.027224438,-0.04864308,0.0076222005,-0.027194941,0.041427214,-0.06294439,-0.0184946,-0.019463314,-0.068595834,0.039518315,0.016739152,-0.08691664,0.04561986,-0.0745509,-0.03136645,-0.034823265,-0.021935437,0.019424012,-0.026136314,0.0553335,0.09819446,-0.0050747725,0.05588197,-0.075662866,3.8591195e-34,-0.007910139,0.122450374,-0.011423332,0.0020894005,-0.0780262,-0.037855476,-0.043623377,0.011764906,-0.13606496,-0.017732574,-0.10303894,-0.093790255,0.056023713,0.11030994,-0.05407501,-0.007891669,0.022803761,0.0050581153,0.02278211,0.026410116,0.052143667,0.041535106,-0.017556893,0.020607071,0.068327464,0.061707165,-0.10599498,0.07581214,0.07326929,-0.008492747,-0.02003434,-0.12112802,-0.008109351,0.06712965,0.012457578,0.07341494,-0.014314858,-0.08532829,0.0015072857,-0.030128755,-0.016567519,-0.02380032,-0.03711156,-0.01958188,0.04622194,0.041209668,-0.08680983,-0.09192788,-0.013666118,0.012365117,-0.008830938,-0.033581477,-0.02979894,0.023208054,-0.013748001,-0.00057780364,-0.05565687,0.019649401,0.008091328,0.02182329,-0.03224428,0.048108634,-0.04019901,0.0022788397,-0.026567956,0.03604581,-0.04706055,-0.099499546,-0.104451545,0.0087452335,-0.05405253,-0.057754334,0.12878454,-0.014288554,0.06869254,-0.05187855,-0.031023871,0.0014608484,0.047451627,0.017169027,-0.027946636,-0.008665979,-0.03394678,-0.058595512,-0.03398711,-0.06419804,-0.027701333,-0.014403224,0.08041845,0.07328269,-0.0662234,-0.06595577,-0.062668756,-0.030456781,0.051617384,-7.2411995e-34,0.046520375,0.043374717,0.021029757,-0.014748696,0.021241754,0.018994534,0.048903763,-0.08211101,0.086637,-0.010938455,0.06632667,-0.008386568,-0.012356466,-0.070040494,0.0308253,-0.0054012183,-0.07313458,-0.008400051,-0.0124902725,-0.027595686,-0.05380833,0.052678004,0.00013989292,0.06645576,0.035191678,-0.006315068,0.018781139,0.034241676,0.09432098,-0.0051515345,-0.020174468,0.0012400601,-0.042821452,-0.0017785493,-0.011897118,0.048671614,0.004149064,0.062300645,-0.072430395,0.055137668,-0.0575545,0.013359651,0.02673121,0.056834057,0.018069059,0.14316237,-0.005101373,0.012732515,0.054106046,-0.016411697,0.067135364,0.06168376,-0.006440845,0.06622822,0.02262052,0.073434375,0.10029222,0.022968877,-0.047411297,-0.022515638,0.0039389427,-0.05010594,0.04926365,-0.024484366,0.0785486,-0.02081228,0.024488483,0.04628229,-0.02570376,0.0477947,0.04036815,-0.033296864,-0.074582234,0.012412525,-0.0059906915,-0.016830547,-0.15114105,-0.04191529,-0.007003804,-0.03566824,-0.0125402175,-0.022704694,0.06801907,0.060117103,0.05852678,0.0094399955,0.000977112,0.095467575,0.01782857,-0.042319566,-0.027424376,-0.03929381,-0.032946233,0.033065386,0.090427585,-3.7936044e-08,-0.0008786021,0.018946478,-0.014965179,-0.05835597,0.025023915,-0.06356128,-0.0409928,0.051892363,0.06987595,0.07499405,-0.078071274,0.08420278,0.017668238,-0.023334276,-0.010390598,-0.005426621,0.040564686,0.027085084,-0.0013520704,-0.039554834,-0.058989935,0.02069546,-0.0685379,0.0014426316,-0.07138869,-0.07659164,0.08767647,0.06483689,0.047901955,-0.03299212,-0.009558021,0.044002157,-0.047427632,-0.020011965,-0.03555462,0.018747179,0.018566996,-0.048151877,0.028671304,0.084493786,0.030811824,-0.033021767,-0.030886766,0.047334194,0.009549605,0.03601414,0.04109611,-0.046778973,-0.017253598,-0.0036871992,0.057999592,-0.058067963,-0.09708127,-0.09628365,-0.05004616,0.05475464,-0.07197527,0.05217892,0.07651455,-0.040782943,-0.008435734,-0.01992824,0.17301561,-0.08050861 +2.4.1.205,Galactogen from Helix pomatia is the most effective acceptor.,384,1.0,-0.024507537,-0.08223543,-0.03453697,-0.04865209,-0.009502014,-0.023996823,-0.0004692276,0.03370124,-0.04588622,0.012596767,0.09504624,0.025050746,-0.08234599,0.09472779,-0.058578555,0.07779268,0.039972894,0.043335736,0.060290556,0.050110947,0.063770786,-0.060902804,0.06251575,-0.0077071907,-0.037027847,0.01697742,-0.004630959,-0.06547665,5.933934e-05,-0.17302315,-0.02339266,0.01674681,0.06995358,-0.0765858,-0.092026055,0.0075482116,-0.030545088,-0.052858472,0.012994371,-0.020774737,0.05180701,-0.008824114,0.0677292,-0.020583386,-0.009347354,-0.073544875,0.047053427,0.050257593,0.03664191,0.0043603107,0.0128073385,-0.06502652,-0.061963614,0.015199971,-0.056263458,0.11228598,-0.07062345,-0.07741468,0.027393095,-0.071991354,0.048014816,0.030065455,-0.025218584,-0.028590053,0.0084517505,-0.03760829,0.031358354,-0.07869971,-0.003248811,0.010379531,0.03048019,0.0066563874,-0.024338225,-0.0025896877,0.054064933,0.11221731,-0.013471652,-0.041982006,0.11042082,0.100032,-0.032100346,0.02575353,-0.050872535,0.06317211,0.06626074,0.042997368,-0.014191993,0.0670083,-0.05473491,0.0023174197,0.057743974,0.012857623,0.0268955,-0.012662693,-0.055917453,0.019857936,0.020775862,-0.04086913,0.0176501,-0.051563717,0.016378162,-0.07246736,0.018650018,0.014639179,-0.025958555,0.018096903,-0.060022604,-0.042699542,0.06301364,-0.020409321,-0.033073884,-0.028793857,0.013525038,0.013834841,-0.056239206,0.10545548,0.04467065,-0.002904664,0.039753497,-0.0006818715,-0.002148646,0.013624828,0.03633487,0.011832074,-0.0070791966,0.010644893,-0.05000119,4.475894e-34,-0.016082847,0.07931735,0.077470295,-0.011185811,-0.042528078,0.07348993,-0.07114543,-0.06467501,0.049023855,-0.051729567,-0.17922945,0.040855143,0.020879658,0.033117875,-0.06469716,-0.017595187,0.04062944,0.043948878,-0.037431013,-0.012137776,0.050657887,0.07903864,-0.080342844,-0.060224496,0.047263443,0.013502038,0.003978643,0.023809103,0.08789264,0.010583961,0.09951993,-0.02402629,0.0003828451,0.038932625,-0.010020809,0.02891234,-0.021570357,-0.09797933,0.012410582,-0.027575893,0.0016977449,0.03230153,-0.020256454,0.042940542,0.06531598,-0.064635195,0.03636123,-0.024395732,0.009572825,0.011292053,0.020612149,-0.044266455,-0.047665,0.017647335,-0.038059648,0.048431247,-0.053399354,0.073266566,-0.0028975895,0.040253256,0.011252733,0.031559005,0.0014819206,0.039815523,0.010943803,0.0244313,-0.028061956,-0.057410136,-0.09039235,0.07739263,-0.05735948,-0.008417804,0.002392352,0.044103973,0.016429497,-0.071023636,0.008352257,0.022850636,0.045520876,-0.062194914,-0.093972996,0.012179442,-0.03442535,0.032126166,-0.045491807,0.034765277,-0.025776822,0.020673739,0.05458019,0.040461324,0.028522601,-0.032380823,-0.03874848,0.0066110855,-0.0019891432,-1.0144046e-33,0.08103213,-0.17033644,0.1215848,0.025344416,0.021660177,0.10771727,0.057133727,-0.036220536,0.07912875,-0.023058705,0.04803402,0.02491287,0.06536068,-0.06898365,0.049966678,-0.00696865,0.023198912,0.04232145,-0.04371057,0.0008882559,-0.053455323,0.055416413,-0.038087726,-0.017094752,-0.026766162,-0.009123002,-0.019769795,-0.048479497,-0.01174431,0.03885159,-0.05940208,0.030657737,-0.04439689,-0.082667954,-0.0004600155,0.024254983,-0.033061463,0.048901256,0.0011702426,0.021009691,-0.042774368,0.0038852585,-0.0009701985,0.10590542,0.049069107,0.025554787,-0.03488401,0.039779585,0.047817912,0.06883899,-0.03266561,-0.0260035,-0.00745597,-0.036241,0.031360727,0.023189556,0.0061617247,-0.063504376,0.02470673,0.011320744,-0.05812239,-0.044897012,0.019855144,-0.04995297,0.05580698,0.04216285,0.0051072505,0.09082427,0.007955594,-0.060064606,0.072498366,0.058984082,0.02402395,0.09853705,0.072362974,0.018903557,-0.077571526,-0.10733734,0.05363204,-0.04197114,-0.019727448,0.06343325,0.009535249,-0.028767083,0.036091555,-0.03449623,0.038095534,0.029389162,0.010340337,0.044364486,-0.05608948,-0.0031604927,-0.0108892545,-0.017189024,0.069040716,-1.8039884e-08,0.05079431,0.046008065,0.030045059,-0.10580605,-0.077925384,0.051408388,-0.05128779,0.0056985193,0.024647765,-0.10688412,-0.018456824,0.12609889,-0.0015112213,0.0008551419,0.023298578,0.01720105,0.002812569,-0.013863125,-0.056150347,-0.008145221,-0.08986736,0.059699435,-0.018766435,-0.027233195,-0.04023303,0.007355421,0.09930746,0.06224813,-0.03288579,-0.044021603,0.054050658,-0.028220834,0.010605706,-0.03506236,-0.057958797,0.10842163,0.020084482,0.005235744,0.039455228,0.06693009,0.09604806,-0.05287593,-0.033246327,-0.056748267,-0.06963649,0.004327953,-0.019553732,-0.02580305,-0.026539344,0.041150264,-0.032341436,-0.013636828,-0.08033794,-0.05916201,-0.10866095,-0.034106985,0.005469234,-0.06868022,-0.012439729,-0.07080237,0.016650243,-0.06135699,0.12105633,0.035972275 +2.4.1.207,Does not use cello-oligosaccharides as either donor or acceptor.,384,1.0,-0.03129766,0.005730664,-0.043089677,-0.007075026,-0.10758583,-0.07546076,0.028157035,-0.035707105,0.06596904,-0.0080052605,0.0798158,-0.028187755,-0.07402664,0.047424894,-0.057172053,-0.031204067,0.06234764,-0.0021351343,-0.018602671,0.064023905,0.010599628,-0.06337748,0.029003702,-0.041473396,0.113955535,-0.0434819,-0.048479043,-0.030992886,0.012851542,-0.056887537,-0.033376195,0.0036909552,-0.008919776,0.0041793953,0.025129508,0.06318648,-0.013439389,0.0066625793,-0.018793598,-0.020744301,0.066043995,-0.00169024,0.048939824,0.029274408,-0.07062814,-0.060449015,-0.01586089,-0.048272684,-0.03351544,-0.020425899,-0.053984605,-0.066722244,-0.004553581,0.0579733,-0.029776774,0.033060916,-0.025261765,-0.0013724128,0.07742294,0.052565727,-0.0042861616,0.01082475,-0.023815898,0.028624017,-0.033851426,-0.05872171,0.017502151,-0.042508118,-0.092762254,0.038356915,0.026918706,0.028875375,0.10369689,0.02205951,0.104577765,0.06472157,-0.02674298,-0.03912701,0.04811157,0.048794292,-0.056657847,0.035869874,-0.0006340324,0.07467046,0.025985882,0.028377904,-0.060460407,0.03303868,-0.10929483,-0.015452019,-0.010212758,0.035276797,0.055118848,-0.045616224,-0.08416572,-0.07337764,0.024719544,0.055187043,0.018402305,-0.014473228,-0.0036088377,0.015179166,0.09940636,-0.023466134,-0.03978637,-0.0026177797,0.024909317,-0.019735733,0.046098482,-0.026289057,-0.034519665,-0.0008597191,0.038584728,-0.0149821285,-0.09398275,0.057314426,-0.0019377375,-0.09804634,0.002396047,-0.006090074,-0.047065563,-0.056466892,0.058848336,0.012913494,-0.08524726,0.015835792,0.036884252,3.2210198e-34,-0.03598854,-0.025361625,0.031734735,-0.01698476,0.008689517,-0.018785723,-0.011581242,0.008059566,0.00693175,-0.06425367,-0.063880965,-0.0032428803,0.054064754,0.118914746,-0.004036485,0.032609817,0.0017441816,-0.06182134,0.056232385,0.003471634,0.06033598,-0.009573712,-0.027579017,0.023944434,0.027793437,-0.020341378,-0.028685516,-0.010683602,0.054284092,-0.0043956093,0.11304807,-0.010417029,-0.013363158,-0.03434229,-0.012152261,0.080531545,-0.023740012,0.004967011,-0.03712605,-0.07212297,-0.028429456,0.08021373,0.005414074,0.046733744,0.068411976,-0.024737267,0.0056828377,-0.061015263,-0.025102308,0.05435986,0.0665731,0.029878428,-0.080499135,-0.054642133,-0.01057313,0.056139797,0.058689963,0.056534924,-0.052728977,0.0058272053,0.00925655,0.00073579006,-0.031764995,-0.047742616,-0.043997373,0.1012064,-0.00014685496,-0.07070449,-0.040180802,-0.06777778,-0.06615609,0.010380369,-0.04441751,0.037483912,-0.0043379413,-0.041846216,-0.042144608,0.0028183372,0.096111484,-0.097353496,0.070239864,-0.03537472,-0.019415727,0.06512245,-0.061265886,-0.012835197,0.004173353,-0.009950223,0.04904265,0.06283511,0.03075925,-0.014373645,-0.09054743,-0.031302173,0.006006002,-2.4922405e-33,0.08992271,-0.078040086,0.059544165,-0.023973102,0.018449586,0.041864034,0.06085923,-0.021726308,0.1334555,-0.046019718,0.14144385,-0.0043244744,0.04819522,0.02926004,-0.002630698,0.009690667,-0.13927785,0.031797405,-0.033844642,-0.02253413,-0.09296374,0.0881974,0.061415177,0.009295834,-0.00712301,0.016508287,-0.0677479,0.007838355,0.042668413,-0.0068565668,-0.027201468,0.01798119,-0.08801733,-0.11990294,-0.07445833,0.007781344,-0.07456972,-0.03802232,-0.017001068,-0.032750506,-0.0154145695,0.0008804598,-0.023136066,0.044439126,-0.031305857,0.050841097,0.012101005,0.019318439,0.041461077,-0.043377418,-0.021162016,0.022666274,-0.057658333,0.0038540072,0.08422542,0.07681055,0.10111496,-0.10055676,-0.03326484,-0.15526678,-0.024661448,0.02450451,0.068983324,-0.07946213,0.044246573,0.022076886,-0.011255948,0.066242315,0.048166875,-0.004213046,0.0723908,0.024479125,-0.0078523215,-0.034010686,-0.034912013,0.009509464,-0.102861136,0.007274873,-0.010086627,-0.02164456,0.011518638,0.05393266,0.038080472,0.045914207,0.14327325,-0.060031574,0.060911287,-0.031962626,-0.09327241,0.1358226,0.0004088116,-0.0006121689,0.092872664,0.06461862,0.11455952,-2.04191e-08,0.014992684,0.06187337,-0.0302448,-0.04929769,-0.08625555,-0.05755474,-0.036867764,-0.05017433,-0.021778572,0.020604093,0.020589553,0.12033367,-0.046319563,0.057166524,-0.031785615,0.010675929,0.027045373,-0.05551868,-0.021858826,-0.02438736,-0.12900476,0.031450313,-0.019432252,0.047437802,-0.025253044,0.0060730553,0.035727337,-0.022442658,0.00829157,-0.045323506,0.015317715,0.059088852,-0.036178604,-0.027804181,-0.012439276,0.024866391,0.002365058,-0.01921907,-0.020586487,-0.0020065769,0.052597802,-0.028290207,-0.057521664,-0.008806625,-0.0023840573,0.03190092,0.019470075,0.0034962047,-0.08611437,0.07690114,-0.016554346,-0.049519148,-0.021361312,-0.031594362,-0.022110619,-0.035213117,-0.00865581,0.07292964,0.06223203,-0.027803786,0.03865427,-0.03634285,0.108563535,-0.019444218 +2.4.1.208,The enzyme from Acholeplasma laidlawii requires Mg2+.,384,1.0,-0.0961057,0.0016457886,-0.049785495,0.041415635,-0.07423032,-0.019443205,-0.083055176,0.05580164,-0.046717502,0.027099403,0.00046663068,-0.0060421876,0.006281365,-0.00036105266,-0.021523044,0.03541518,-0.004387558,0.027592173,-0.022259999,-0.08600178,0.07001497,0.026158897,-0.0028703376,-0.054705076,0.005909974,-0.007920501,0.011519508,-0.0024477537,0.0069723898,-0.016475707,-0.06868912,-0.020391157,0.016647644,-0.034831222,0.07564214,0.03547178,-0.08670278,0.038019683,0.033820525,0.013927217,0.019301843,0.00010249922,0.08937905,-0.020051956,0.014033015,-0.08277027,0.014342131,-0.01731721,0.073795326,0.12107051,-0.053636882,0.008264466,-0.0641507,0.021509279,0.0048294147,-0.005944265,-0.103696406,-0.007650805,-0.057817925,0.05602816,-0.0058550457,-0.040988967,-0.034590796,0.01012435,0.031948395,-0.025689997,0.03283765,-0.06440057,0.028556941,0.06834527,-0.0076349815,-0.039301533,-0.01680345,-0.004027886,-0.04366849,-0.024877666,0.046675026,-0.08839594,0.107610665,0.02310085,0.025956454,0.020477291,0.048961394,0.051084157,0.010526588,-0.07027031,0.11160422,0.047332037,0.013171562,0.08030371,0.046772182,0.056632247,-0.040314034,0.032121927,0.04961891,0.040344864,-0.035545185,0.007863344,-0.07577115,-0.012341271,-0.0138952825,0.0012546948,-0.002789149,-0.05161241,-0.054738406,-0.0031676732,0.0011390563,-0.03088953,0.065657265,0.06643802,0.047778532,0.0067700767,0.0006255042,0.03321927,0.009846521,0.08663739,0.036409557,-0.08023858,0.0018004208,-0.035407823,-0.044531923,-0.014190046,0.025229348,-0.0009958884,0.00056417414,-0.025228355,-0.08656436,-1.0038944e-34,-0.028054226,0.016991716,-0.01146911,0.027307488,0.00795179,0.017671352,-0.053247076,0.008162449,-0.07257401,0.05095432,-0.09388612,-0.07272793,-0.04754164,0.01289016,-0.023822853,-0.019794807,0.08777162,-0.014941493,0.0076041026,0.027069846,0.010380689,0.072828405,0.04377357,-0.017014695,0.08281551,0.10468858,0.058076076,-0.07098034,0.04992465,0.0043474105,0.042113032,-0.08043027,-0.022223487,0.0070868237,0.06898725,0.07595939,0.013141053,-0.029066442,-0.06762,0.03637868,-0.039664,0.010988816,-0.03615621,-0.004711412,0.017847186,-0.10695525,-0.10481825,0.04266895,0.021894628,0.08412471,0.036874764,0.08851827,0.05013831,0.05872561,-0.055883147,-0.0023147843,-0.10761111,0.059806935,0.06108138,0.00012755915,-0.008762753,0.0003659982,0.03412014,0.058396295,-0.013166619,-0.018165354,-0.07805899,-0.0127152065,-0.0482608,0.07028042,-0.019837035,-0.04292424,0.018160572,0.045156974,0.028701723,-0.03132837,0.024708273,0.08181929,0.016935106,-0.000786412,-0.07102774,-0.04480848,0.047553696,-0.028510401,-0.08836364,-0.04759996,-0.03920304,0.054259058,0.023464419,-0.02974674,0.05646087,0.01919203,-0.057026032,0.06537365,0.02595166,-1.229355e-33,0.0060437955,-0.04524463,0.055207033,-0.04409284,-0.05503716,0.05622422,0.023068385,-0.04880748,0.03845583,0.11149317,0.08498361,0.063101284,-0.016148321,-0.13350402,0.03322832,-0.066227995,-0.015586969,0.061453134,-0.03922364,0.007384963,-0.04695101,0.11461976,0.032738842,-0.008187195,0.04225736,0.043527238,0.009275861,0.03709769,-0.043452498,0.05249865,-0.039780777,0.087879546,-0.08682439,-0.085317746,-0.098567896,0.010697282,-0.005035584,-0.047121894,-0.09695367,0.100753546,0.021265982,0.04828186,0.02494547,0.1696101,0.038088813,0.0066367458,0.015038555,0.01721543,0.052172903,-0.07796741,0.03728229,-0.013294876,-0.017710293,-0.031500496,0.07139615,0.017132727,-0.0654064,-0.046968292,-0.0136968475,-0.022819947,0.033990785,-0.07892385,0.043735623,-0.04677479,0.07522804,0.068772435,-0.0029775347,0.0017970316,-0.009121748,0.06646693,0.03059736,0.041259985,-0.020750903,0.046073884,0.020078665,0.039296318,9.6168376e-05,-0.015870541,0.0019428061,-0.06619459,-0.0034206444,0.011752178,0.030408815,-0.03914607,0.08396703,-0.10655453,0.01456827,0.045878544,-0.0480067,0.049842134,-0.065376796,-0.0007239708,-0.06747143,0.030457145,-0.041479964,-2.1013014e-08,-0.012301665,-0.016652912,0.0011839687,-0.098115936,-0.0050833304,0.071350746,-0.05132316,0.016759468,0.06761129,-0.028985193,-0.06765068,0.028428126,-0.015856648,0.017970927,-0.015144459,-0.028356027,-0.037815817,0.040399976,-0.04196304,0.0015245246,-0.092442945,-0.03978325,-0.13664389,0.08974478,-0.024542997,-0.014355106,0.05436655,0.052867495,-0.033027858,0.052353255,-0.059189744,0.0043228664,0.020676374,-0.033538114,-0.12402143,0.01842689,0.10329887,-0.04876788,-0.035814326,-0.0813831,-0.022085523,-0.07203324,0.11197307,-0.029113628,-0.058148425,-0.052559186,0.040417217,0.005067284,0.003343557,0.07016034,0.015542888,-0.024603253,-0.038884785,-0.041597407,0.011657972,-0.034802575,0.044418458,-0.05492761,-0.017329777,-0.06719503,-0.033094015,-0.0333286,0.12181847,-0.027368871 +2.4.1.209,cis-Caffeic acid also serves as a glucosyl acceptor with the enzyme from Sphagnum fallax kinggr. The corresponding trans-isomers are not substrates.,384,1.0,-0.053676214,-0.10542441,-0.09656025,0.057853498,0.05074036,0.05080561,-0.041995678,0.08062502,0.079120964,-0.07890841,0.06806228,-0.067750566,0.018735014,0.007988065,0.005084913,-0.05618967,-0.000341739,0.0118127465,0.038930763,-0.054366756,0.013441157,-0.05755579,-0.035525423,0.03407896,-0.057036858,-0.014005774,0.010478911,-0.0360452,-0.010317322,0.007474882,-0.04205788,-0.0063112336,0.028862001,-0.03001331,-0.032724906,0.07442359,-0.021736799,-0.037443217,0.14761819,0.006862337,0.02129186,-0.026338506,0.05536054,-0.034530662,-0.010754038,-0.07666319,0.02436413,-0.032759216,-0.033120926,-0.01720725,-0.0074287914,0.019300206,-0.030742632,0.012225102,-0.038717076,0.02929457,-0.053701963,-0.047051907,0.023545502,0.09912728,0.09174826,-0.081600234,-0.04218388,0.02339798,-0.038102586,-0.05899318,0.012542147,-0.07980666,0.03871532,-0.034271553,-0.08606366,-0.02731527,-0.034103554,0.035874162,0.035727102,0.07378899,-0.008911172,0.024699925,0.07340693,-0.03568356,0.08045941,0.073236525,0.024632134,0.02673227,0.023027686,-0.008966355,0.034702048,0.031984765,-0.041467737,-0.0050759767,0.07601195,0.01665221,0.052394096,0.026581468,-0.029349435,0.011557858,-0.01940995,0.03396776,-0.0020937715,-0.01984106,-0.010524037,-0.019942684,-0.059667934,-0.062751226,-0.09452263,-0.0028476957,-0.123732455,0.058490135,0.051528536,0.041213155,-0.018559042,-0.0034417147,0.015380504,0.047115136,-0.02611447,0.08724545,0.02794046,-0.06444567,-0.008450885,-0.05302952,-0.038824372,0.00072373275,0.022906305,0.010359732,-0.048820212,-0.035378467,0.022432733,1.6175794e-33,0.0074688722,0.027673678,0.057667132,-0.07079144,-0.012139603,-0.04888328,-0.0783398,-0.027613416,-0.04974518,-0.00046270856,-0.10368193,0.018322468,-0.036356863,0.08822413,-0.046640273,-0.004018884,-0.009394962,0.02920708,0.07378851,-0.037976675,0.06118883,0.093174934,0.0042956686,0.030274244,0.03586653,0.079790965,-0.07938979,-0.027497971,0.01573154,-0.03011579,-0.0153462645,-0.047393937,-0.017654339,0.045167986,-0.0022732029,0.020324461,0.012890681,-0.0028219442,-0.016393518,0.06654406,-0.0071305307,-0.008188445,-0.035412807,0.009625119,0.048482254,-0.014404462,-0.05918759,0.012938432,0.0071156854,0.070873655,-0.043050885,-0.010446484,-0.0059015974,0.009650764,-0.007175943,0.025067123,-0.012611859,0.05441571,0.057147466,-0.0034819348,-0.014663893,0.061539594,-0.00016472944,-0.01658891,0.007479941,-0.0026437219,-0.110445574,-0.048001535,-0.019655703,0.025809541,-0.04745869,0.045635022,0.003073065,0.03764827,0.081463374,-0.053404182,-0.16665448,0.018149333,0.009464811,0.041259144,-0.07932282,0.0086006,0.0017636551,0.019559273,-0.10820665,-0.004627041,-0.0053376374,0.037247147,0.028202374,-0.008921692,-0.072879314,-0.011023737,-0.045350917,0.10383907,0.04958994,-3.383751e-33,0.1196577,-0.13868809,0.048671477,-0.048659515,-0.022138696,0.0794165,0.08061295,-0.09631094,0.0074331383,0.022414707,0.10717438,0.075184986,-0.018869776,0.054890413,-0.04347429,-0.0498622,-0.0067301085,0.077843346,-0.085512295,-0.0038299134,0.008396284,0.07242668,-0.043084826,0.051554374,0.04916387,0.0150626125,0.069831096,0.052718014,0.012084897,0.11770023,0.012346846,0.009017773,-0.013970448,-0.020836035,0.05256166,0.0053454023,-0.0580411,0.026166892,-0.090352006,0.045178633,-0.04618482,0.04704341,-0.01135754,0.026737042,0.06470422,0.025287768,-0.058336552,-0.02912892,-0.02238038,-0.00065240765,0.0029106305,0.013770718,-0.05430264,0.011484375,0.04935639,0.04252544,-0.042506855,-0.004266891,-0.07240929,-0.014675209,-0.093380526,-0.042246412,-0.016118467,-0.10275344,0.08066897,0.0930032,-0.014959637,0.0081704715,0.03236391,-0.06198961,0.17021285,-0.02049554,0.015876135,0.013972043,0.028510036,-0.025544457,-0.026430134,-0.033012345,-0.039239958,0.026191344,0.030632567,-0.04894967,0.03215424,0.014263532,0.012279474,-0.0012779196,-0.0074778926,0.0014063361,0.06959743,0.04156343,-0.011292706,-0.04836239,0.02114164,-0.031634644,0.11912478,-3.1995874e-08,-0.023874233,0.00014273335,0.008092034,-0.031910338,-0.062493376,0.031666536,-0.000799598,-0.115054205,-0.010466243,-0.06824349,-0.02243063,-0.023191998,0.021204013,0.0538721,0.0332634,-0.008165833,0.0020557726,0.07957011,0.030073287,0.01899379,-0.13558266,-0.07498846,-0.04711579,-0.044108227,0.033360645,-0.090336,0.06150004,0.032159757,0.037702166,0.036172412,0.016270954,-0.018562159,-0.009782505,0.07426876,0.013680841,0.03773517,0.021758711,0.019227255,-0.0174762,0.05734082,0.03587752,-0.12224452,-0.08578281,-0.025135342,-0.0051199114,0.06346072,-0.026791675,0.038217958,-0.028859304,0.091410466,-0.0335651,0.0049960483,-0.029722817,0.0030733175,-0.04941805,0.0082164295,-0.037341785,0.021812651,-0.06926858,-0.090258196,0.0066311797,-0.0032006775,0.18598574,-0.06488983 +2.4.1.210,The enzyme purified from navel orange albedo tissue also acts on the related tetranortriterpenoid nomilin.,384,1.0,0.0024549137,-0.036700208,-0.034867328,0.055732977,0.062619515,-0.0318192,-0.0076069697,0.014686148,0.07208633,-0.015798027,0.096668884,-0.050618757,-0.0034739235,0.077174686,-0.03240868,0.036750738,-0.028146934,0.015604118,-0.028466431,-0.07727387,0.018474486,0.063649684,0.026571805,-0.041888885,0.015337649,-0.12943156,-0.055443723,-0.014166712,0.029963532,-0.055679616,-0.004419122,-0.04890854,0.014226357,-0.00045405497,0.07269748,-0.005497811,-0.061297696,-0.08835905,-0.037383184,0.063519776,0.041701067,-0.012443925,-0.06798889,-0.0149133755,0.014282121,-0.022230413,-0.03006749,0.0037315923,0.04546409,0.062536106,-0.014056506,-0.06528163,-0.013788918,-0.024502903,-0.044981603,0.024599055,-0.07082873,0.0015616536,-0.058867976,0.049626727,0.10239113,-0.0037593583,-0.037799034,-0.018070398,0.033865295,0.04336931,0.033733718,-0.050626762,0.01852308,-0.074134625,-0.034250345,0.0044199387,-0.012190863,0.021520307,-0.062300198,0.042506173,0.016448967,0.019744517,-0.051840138,0.0038948813,0.048013028,0.03333292,-0.051496673,0.08400148,0.044326074,0.014966506,-0.03700683,0.045283683,-0.0016088979,0.09290422,0.028843725,-0.019848727,-0.030385386,-0.012701085,-0.09156954,-0.0005051474,-0.046481363,-0.011148387,-0.10435511,-0.03666363,-0.064278245,-0.029670138,-0.062206242,-0.035111386,0.016728792,0.048411172,-0.0030040024,-0.10526797,-0.01633882,-0.007129247,0.047281615,-0.007475387,0.033177502,-0.057174876,-0.020801108,0.027872976,0.021312961,-0.024139242,-0.0009758488,0.050421063,-0.0023053263,-0.0029318049,0.02312525,0.05852077,0.00069446635,-0.0011882134,0.017391985,1.7068802e-33,0.0007751232,0.1175481,-0.022940217,0.027144335,0.049136784,-0.0332829,0.014917088,0.017565832,-0.040997393,-0.04252389,-0.09037497,-0.01570706,0.011586717,-0.001932122,0.06770114,0.029532088,0.022221323,-0.040332574,0.035033572,0.03909747,-0.053166457,0.11914526,-0.055272933,-9.3948474e-05,-0.03170243,0.057834502,-0.06531148,-0.028105913,-0.026239043,-0.0048297723,0.03916879,-0.088553816,-0.01001576,0.06557932,0.062754236,-0.014257777,0.067873955,0.0026719295,-0.0107664475,0.03495078,0.02761666,0.03642113,0.0030931083,0.07587363,-0.0012631541,-0.045421243,0.009694641,0.08747421,0.09472472,0.0007168418,0.06489049,-0.0026427058,0.048276227,-0.111593045,-0.09673352,-0.011677961,-0.0331575,0.014169105,-0.021402128,0.018547524,-0.020646013,-0.041854925,-0.011096507,-0.027832815,-0.028839683,0.028491655,-0.07692735,-0.06627579,-0.06536111,0.035166487,-0.09613555,0.053778406,0.050266717,-0.04317507,0.018242596,0.0030652795,-0.06148965,0.024327656,0.053008646,-0.049877647,-0.0070197424,0.013483321,0.04084826,-0.049235158,-0.06676583,0.0225754,0.049450584,0.15614915,0.05337361,0.01031322,0.11283391,0.015834253,-0.022400824,0.0058775437,0.015355061,-1.8996077e-33,0.07041359,-0.078452416,0.052806456,-0.044261184,-0.02601803,0.10702065,-0.09254636,0.028750656,-0.020022644,0.03943414,0.07358855,-0.008537314,0.007227764,-0.06282136,0.030878212,0.0051512057,0.017745258,0.14067847,-0.063079946,-0.05629456,-0.15825906,0.053098354,0.04627905,-0.00035139843,-0.06302852,0.09767341,0.056812834,0.00050305884,-0.010073324,0.06713059,0.001201643,0.014364963,-0.03712224,-0.031262964,0.022244556,0.088586375,0.02861087,-0.04572315,-0.032989662,-0.01795514,0.020868596,-0.082007125,0.07083862,0.04342169,-0.0007661433,0.04131005,-0.08459716,-0.014554997,-0.05258231,-0.024734646,0.13100706,0.009665541,0.00029171986,0.048754975,0.0053011808,0.097085364,-0.034035563,-0.07794869,0.035695087,-0.015477232,0.042630915,-0.0967084,0.028890109,0.02518643,0.054600175,0.025388129,-0.0059957355,0.10298872,-0.006180533,-0.0039606537,-0.030948404,0.041882496,-0.02158068,-0.04243409,-0.016515207,0.029513678,-0.03688686,-0.08794402,-0.017490912,0.015870742,-0.13628548,-0.010383993,-0.013895168,-0.06668891,0.047059353,-0.04943272,0.0006817262,0.076423466,-0.023029294,-0.027872644,-0.0082378555,0.02151075,-0.090693764,0.018110579,0.016465023,-2.3299627e-08,0.07979234,-0.06331168,-0.028538812,-0.016385125,-0.031383287,-0.014046635,0.0042800126,-0.004045837,0.03914198,0.035343286,-0.017760746,0.102286525,-0.020780643,0.03903417,-0.009531963,0.016038459,-0.026585506,-0.03241194,-0.0013752275,-0.0028325222,-0.07871516,-0.0068507954,-0.03013095,-0.055428173,0.026382558,0.00073950185,0.032100026,0.14489992,0.050793093,0.038188998,0.033148002,-0.03079816,-0.033915296,0.0026124052,-0.10088717,0.00097283826,0.10517731,-0.016683973,-0.009623163,0.070422746,0.006322751,-0.047090057,-0.06926705,0.05378701,-0.039881308,-0.024373747,0.07029577,-0.028812705,0.024175929,0.02852938,0.02228278,-0.07966315,-0.046389267,0.050808717,-0.14379686,-0.123079844,0.06602061,-0.012172099,0.016302744,-0.017662134,-0.013482279,-0.03615121,0.1344331,0.04365141 +2.4.1.211,"Reaction also occurs with beta-D-galactopyranosyl-(1->3)-N-acetyl-D-galactosamine as the substrate, giving N-acetyl-D-galactosamine as the product.",384,1.0,-0.0233938,-0.102525406,-0.049526792,-0.012915428,0.0499071,0.029935868,0.06688931,-0.014101995,-0.013652305,0.060825203,-0.012408816,0.0067987116,-0.025923993,0.025789898,-0.05701558,0.07054787,0.032410752,-0.014328443,0.073576905,0.0665717,0.1095358,-0.04111592,0.023200734,0.040765144,0.06599833,0.028472753,0.06061614,-0.049378265,-0.025139688,-0.10298056,0.009969442,0.00026689714,0.084081285,-0.023643842,0.0014621458,0.016804414,-0.027828023,0.00034581972,-0.029632255,-0.0027766633,-0.013240391,-0.022522135,0.024703851,-1.6424472e-05,0.0016400563,0.007543412,-0.052452937,0.04855143,0.0987255,-0.037067454,0.031039279,-0.045721117,-0.05886234,0.036165383,0.054686412,0.09005436,-0.057321817,-0.054073624,0.034005817,0.028676635,0.09680061,0.07202664,-0.044215985,-0.022041032,0.03163762,-0.051033963,0.0066918097,-0.05385807,-0.0074089626,0.040041305,-0.015337591,-0.032281544,-0.06662622,-0.072183415,0.04794497,0.023201667,0.028400954,-0.038223222,0.06695437,0.023074234,-0.004097046,0.05830306,0.004358245,0.022863219,-0.004712402,-0.0057991524,0.019575754,0.036299422,0.08835477,-0.008567419,-0.053292044,-0.05748168,-0.040083587,-0.0283277,-0.07007545,-0.05018919,0.06622381,-0.019670187,0.08941074,0.05721434,-0.008282204,-0.028421314,0.0025736333,-0.07895383,-0.054864775,0.073677756,-0.011953058,0.05116611,0.027973333,0.04699131,-0.06364256,-0.040080644,-0.0042486144,0.06572799,-0.13939591,0.07361985,-0.016390989,-0.095809735,-0.070047125,-0.042550728,0.091412865,-0.0075795716,0.00753876,0.04571094,-0.018724304,0.07845687,-0.01483626,-4.6573844e-34,0.040558297,0.044615664,0.033847835,-0.015292274,0.020700242,0.0263906,-0.06999769,-0.078903735,0.05099695,-0.03223139,-0.07367236,-0.026322588,0.0692612,0.068664715,-0.037274234,0.052318104,-0.007408901,0.03415599,0.05228707,-0.02447915,-0.0729384,0.058828566,-0.13072138,-0.006074427,0.00061260146,-0.01571127,-0.019568969,0.058379512,0.07201367,0.017989568,0.038267553,-0.012718271,-0.022370126,0.023092277,-0.009464198,0.055347357,-0.034852795,-0.10682797,0.035222437,-0.021579763,0.05735664,0.03628763,-0.015850797,0.047759872,-0.034515142,-0.036440887,-0.025147967,0.019589597,0.032696966,0.02438219,0.0058595343,-0.048173506,0.030410714,-0.0017635088,-0.009342381,0.077686936,-0.11496714,-0.0703312,0.089755215,0.03884455,-0.04417687,0.0084100785,0.0059224432,0.025785329,0.02292706,0.016379252,-0.0033878987,0.0013234712,-0.02111086,-0.0654662,-0.06583159,-0.02675921,0.0364917,0.009577291,-0.01891239,-0.053555634,0.01702282,0.013279652,0.040014174,-0.051808417,-0.014514376,0.0047860797,-0.022201803,-0.049483355,-0.024358552,0.03702661,-0.032571115,-0.063734196,-0.023142075,0.08671092,-0.029526373,-0.07199266,-0.0594546,0.065582186,0.03503093,-1.5578994e-33,0.050136764,-0.116451465,0.050568324,-0.06409978,-0.0106842285,0.06510641,0.03776811,-0.09507569,-0.0014898325,-0.037229028,0.000877559,-0.030603522,-0.056992907,-0.04276478,0.023810571,-0.021470178,0.08224385,0.07576021,-0.015413257,0.009865465,0.0382655,0.05748221,-0.038457178,-0.010465668,-0.050661776,-0.05391806,0.015240297,0.0039141085,0.052682113,0.110154316,0.021326067,-0.032181837,-0.03536988,-0.04073147,0.024201669,0.028763266,0.00966782,0.008283794,-0.057182647,-0.016796684,0.0010280269,0.05546771,0.027573915,0.061012655,0.08371459,0.06271506,-0.04301615,-0.0317465,0.035397336,-0.058909096,0.013261874,-0.07623599,-0.0058197193,0.00654199,-0.012215135,0.07536677,0.04871896,0.04158047,0.046608273,-0.038224272,-0.0044205007,0.006162535,-0.0086002555,-0.1623211,0.07702432,0.023082975,-0.052470103,0.08037013,0.06746151,-0.029932084,0.0439348,0.041651875,0.011721618,0.061926395,-0.018196577,-0.06449262,-0.12597533,-0.056726858,0.0006213748,-0.017142683,0.07432729,0.06741077,0.034660738,-0.013552277,-0.07526003,-0.032690596,0.082853876,0.11032918,-0.062612124,0.0042837625,-0.042872176,-0.024254637,-0.049243145,0.062595375,0.083592914,-3.418075e-08,0.073968194,0.005531209,0.014617744,-0.07270721,-0.06544042,0.026801508,0.030026782,0.0066605876,0.03822798,-0.116317466,-0.032541174,0.15050305,0.042172763,0.0415082,0.007826363,0.011570887,-0.032108344,0.007967044,-0.040809616,2.6121434e-05,-0.08826215,0.022219367,0.000570606,-0.043719407,-0.07645608,-0.053130303,0.09228276,0.09519685,-0.03448876,-0.038720354,-0.0025714776,0.039213013,-0.07287832,-0.045732208,0.0025248895,0.0025521978,-0.014313037,-0.048054267,0.13268948,-0.008870138,-0.016310785,-0.0064256852,0.043662526,0.022772986,-0.04935071,0.008660015,-0.031099081,-0.010111121,-0.07640384,0.043077096,0.008530692,-0.028830113,-0.107620195,-0.102002814,-0.05417491,-0.038351655,-0.007971802,-0.07881867,0.03705809,-0.035225708,0.008909273,-0.030142413,0.10764397,0.05065867 +2.4.1.212,"The enzyme from Streptococcus Group A and Group C requires Mg2+. The enzyme adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc [3]. The enzyme is highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA. Similar enzymes have been found in a variety of organisms.",384,1.0,-0.08220411,-0.11951933,-0.10635631,-0.025958428,-0.0014327033,0.006217221,-0.057575777,0.05985641,-0.021184947,0.022395877,0.055517007,-0.028934505,-0.05601906,0.06937343,-0.067512594,-0.058573093,-0.029766275,-0.004347115,0.055447735,-0.072548,0.09795298,0.032085065,-0.0376464,-0.021972848,0.017760947,-0.033439107,0.024871752,-0.065373376,-0.005848622,-0.051595595,-0.09346187,-0.028806852,0.04515031,-0.062389154,0.08106587,0.12745333,-0.107128665,-0.012474625,0.0636994,0.003621166,0.00585385,-0.0007619934,0.018667083,-0.0035030805,-0.025280042,-0.02520158,0.10386644,0.056056265,-0.0106700985,0.03715365,0.015198023,-0.038406968,-0.107712045,0.0417794,0.015144894,0.024742145,-0.12025698,-0.024282748,0.026866417,0.009612102,0.01410351,0.07431231,-0.003430086,-0.04182876,0.011100089,-0.010110586,0.11308981,-0.083389774,-0.0020754938,0.015737971,-0.03442712,0.011112693,0.0061893794,0.012357623,-0.0030229539,0.041082576,-0.023027178,-0.071945466,0.0352589,0.04051366,0.05092865,0.040813446,0.010670387,0.13862063,-0.005094863,-0.016588463,0.0011279042,-0.01468038,-0.008380071,-0.020500148,0.07469042,0.054601423,-0.059931945,-0.025262464,-0.070491254,-0.016969671,-0.030343672,0.043421015,0.03180825,-0.036308017,-0.062145766,0.0010849794,0.042980883,-0.064990155,-0.0016264837,0.013266807,-0.06363222,0.008238402,0.07362176,0.069629766,-0.018083878,0.10043377,-0.065335535,-0.04620894,-0.017535198,0.09032885,0.049338784,-0.09138441,-0.10008892,0.024182808,0.011250721,-0.016152577,0.08048695,-0.02013672,-0.005560863,-0.008362546,-0.032998867,3.3905606e-33,-0.051853675,0.007268884,0.104095854,-0.064242825,0.025827754,-0.017005952,-0.07483471,0.035882685,-0.002001284,9.974507e-05,-0.08835984,-0.022141093,-0.020479612,0.11178882,-0.06648628,0.0080522355,0.043747924,-0.010883246,0.032422055,-0.027952455,0.0033260493,0.1348333,0.030132147,-0.0031207034,0.0599138,0.019539455,-0.02947453,0.014938144,0.11176325,-0.016974155,0.0444904,-0.10708693,-0.07907345,0.03493687,0.10154769,0.003956122,-0.05467526,-0.08787576,0.02469453,-0.017530885,-0.03318242,-0.0060617547,-0.009018646,0.0009677131,0.04162642,-0.05819186,-0.003178351,-0.0031873616,-0.03741654,0.020153334,0.106362596,0.011307531,0.009028764,0.030566934,-0.07535375,0.015900962,-0.039399367,0.018613854,0.04019977,0.085172,0.012383567,0.033620816,-0.031278577,-0.012374804,0.02323457,0.012625138,-0.07130134,0.0042341826,0.026392754,-0.014417329,0.016592083,-0.06828398,0.011354616,0.05837163,0.005879207,0.024038678,-0.0094257,0.074553125,0.10502494,-0.07019955,-0.0603014,0.019097436,0.050677348,-0.036171388,-0.07531003,0.02088789,-0.0019010288,-0.022738509,0.020251844,0.0397342,-0.022291832,-0.030220788,-0.04221319,0.037348725,0.048453137,-5.1451964e-33,0.06605814,-0.10061726,0.05682799,-0.035600964,-0.026928257,0.025330225,0.08776506,-0.066804044,0.015012188,-0.0060423324,0.08082386,-0.028272608,-0.02193555,-0.033246275,0.017486986,-0.009563333,-0.075640775,0.11397622,-0.04824287,0.02312699,0.021230346,0.077810846,0.02885586,-0.064959794,0.048860457,-0.0037260375,-0.02173791,0.056056075,0.027358098,0.06722291,0.021897882,0.0012564898,-0.06133404,-0.039303463,-0.051969934,0.01305561,-0.02163243,0.02638393,0.044220593,-0.01162756,0.03952103,-0.017961072,0.04784648,0.020247385,0.08097858,0.079882346,-0.02755861,0.025524765,-8.8906905e-05,-0.037772793,0.036386523,0.050721686,-0.00069958484,-0.010974058,0.020714428,0.101030566,0.06758905,-0.045381814,0.051337168,-0.029482681,0.019827945,-0.05923657,0.006314975,-0.01473621,0.095381975,-0.03391334,0.058148526,-0.006803103,0.035133254,-0.033920255,0.032888126,-0.022371769,-0.0011861435,-0.0063554654,-0.015951904,0.036138434,-0.040012646,-0.010096757,0.04839544,-0.068391144,0.03500387,-0.011130064,0.023652647,0.01873929,-0.007198232,-0.074669294,0.1061817,0.031898804,0.042510696,0.07840591,-0.08338597,-0.003986706,-0.029348878,0.021306748,0.048623167,-4.389045e-08,0.006181201,-0.01483285,0.03923683,-0.09838513,0.019836701,-0.04306732,-0.061050635,-0.006157219,0.03735223,-0.008854356,-0.0056312606,0.02120332,-0.06454569,-0.032025125,-0.027420107,-0.032061778,-0.055228274,0.0007811093,-0.028341105,-0.057146095,-0.13380301,-0.0061111636,-0.16164428,0.038413957,-0.025953755,-0.078055374,0.03698906,0.07130484,-0.10922222,0.002050706,0.02321191,0.048013736,-0.012975481,-0.07206684,-0.0284983,0.011028972,-0.0030816582,-0.0003385755,-0.04230197,0.031323727,0.03183363,-0.02658767,0.008904229,-0.015655657,-0.010152273,0.014727127,0.012792962,0.02215858,-0.055198524,0.1051742,0.081406735,-0.035080492,-0.08612777,-0.045675293,-0.04017373,-0.043903317,0.015306973,-0.03551103,-0.07134725,-0.025852108,-0.08946649,-0.05203693,0.12839073,-0.006147332 +2.4.1.213,"Acts with EC 3.1.3.69 (glucosylglycerol phosphatase) to form glucosylglycerol, an osmolyte that endows cyanobacteria with resistance to salt.",384,1.0,-0.140259,-0.014382348,-0.008606196,0.028071336,0.01587421,0.021210574,0.004584501,0.028464375,0.019323098,-0.013600647,0.063836336,-0.05189289,-0.032403767,0.028154349,-0.032445382,-0.0067740637,-0.053953737,0.036987673,-0.053326048,0.060647503,0.1119936,0.07337442,-0.02153641,0.027098292,-0.0018706018,0.050479513,0.035462063,0.06810763,-0.03483157,-0.039429992,-0.019068008,-0.057385046,0.083262905,-0.059658248,0.08420679,0.019472195,-0.038422514,-0.11917357,-0.003485802,0.047271077,0.07233521,-0.013148929,-0.014758164,0.015670525,0.026534393,-0.014030116,0.074699424,-0.013271245,0.024659706,-0.028322168,-0.011698769,-0.048736762,-0.05179681,-0.006027404,-0.0035715373,0.06180137,-0.16632946,0.0108004,0.04121932,-0.0044253245,0.06927364,0.0553322,-0.01518144,0.057465725,-0.002648705,-0.050647214,0.033980682,-0.098969854,0.0024384276,0.01083476,-0.07396376,-0.060187798,0.019423988,0.06683895,-0.017335517,0.016402612,0.047533467,-0.032510135,-0.0051564034,-0.019884229,0.015923273,-0.030973777,0.025047451,0.05701277,-0.0030279716,-0.07421599,0.0097326515,-0.00072616676,-0.0536984,0.028824631,0.04116986,-0.071172684,0.026303725,-0.006026719,-0.021748224,0.080175705,0.021918382,-0.010868815,0.04545077,1.9147935e-06,-0.058727153,0.071353875,0.052563768,-0.07266177,0.10764579,-0.0062676566,-0.014253699,0.043058,-0.0049755205,0.037973557,0.005471609,-0.012144942,-0.005281882,-0.01365147,-0.025876082,0.025970656,0.026333952,-0.018047921,-0.10287216,0.050182454,0.03709068,-0.119206786,-0.027738975,0.037873287,-0.033482287,0.0894144,-0.07341665,3.1207307e-33,0.06042837,-0.049140055,0.03978167,-0.04776358,0.023082633,-0.05059861,-0.039657272,-0.022049941,-0.08153155,-0.07956804,-0.08236075,0.049524944,0.039418958,0.07605193,-0.07156163,0.052886818,-0.063306145,0.006256795,0.084474824,-0.04025707,0.074466705,0.031472266,0.024839593,-0.032622177,-0.02348927,0.048991695,-0.043178204,-0.055096757,0.107391104,-0.0033835017,-0.03367802,-0.10350667,-0.050673444,3.9052135e-05,0.060104974,0.027300498,-0.0409139,-0.09977218,0.030743118,0.01156009,-0.061258715,-0.016134124,-0.028494272,-0.0009218619,0.058913156,0.02609187,-0.07896052,0.08018549,0.085364915,0.03000797,0.076582976,-0.06415716,0.031514045,0.059792235,-0.020875927,0.00017174229,-0.03707493,0.016076053,-0.017751472,0.029777529,0.009397744,0.10052362,-0.03770965,0.037507672,0.021378389,0.028622355,-0.10094714,-0.02886234,-0.022900952,-0.028352989,-0.03547988,-0.051635366,0.023877615,0.07825929,-0.020990621,-0.028218405,-0.0041081575,0.039621253,-0.03371145,0.046022728,-0.01476209,-0.05351453,0.018897932,0.0016997106,-0.05764531,0.00015446745,-0.036703385,-0.08507884,0.05739297,-0.004972723,-0.023036197,-0.03109018,-0.05643661,0.028479118,-0.07652793,-4.7203728e-33,0.10600057,-0.05156238,0.050084446,0.011397683,0.0028280744,0.016012682,-0.058337487,-0.05342133,0.05229072,0.022984505,0.026578024,-0.0673268,0.09185389,-0.0372417,0.0005696247,-0.011032118,0.0065212464,0.042215798,-0.12949906,-0.01893993,-0.008116172,0.045675363,-0.0057205535,0.07080071,0.028568367,-0.040834475,-0.046757985,0.017314155,-0.050805435,0.040094458,-0.02401033,0.03284955,-0.05090735,-0.12356512,-0.022593291,0.05117901,-0.074195296,-0.017162457,-0.0030423068,-0.025826536,0.044796303,-0.023483012,0.05391263,0.052886683,0.08743362,0.08565842,0.044604078,0.008176194,-0.017906627,-0.031490643,0.027484592,0.021283582,-0.023997165,0.07563115,0.0710447,0.10312174,0.034649957,-0.004712754,-0.022266958,-0.0027125892,-0.01051637,-0.11709346,0.06829384,-0.109059535,0.099641785,0.05177757,0.028273487,0.04052571,0.006113799,0.04155984,0.0687916,-0.01916528,0.032566786,-0.0381177,-0.018917095,0.02535067,-0.08339247,-0.06614451,-0.057919655,-0.0628105,0.075817764,-0.022408219,0.03805357,-0.026404057,-0.030700525,-0.0233468,0.049087152,0.0677329,-0.074942924,0.03264699,-0.041981436,-0.053847637,-0.023755956,0.11472639,0.034138717,-3.210534e-08,0.04031376,0.032788835,0.023386471,-0.056972273,0.026823496,0.07278592,0.061851833,0.033848796,0.035814263,-0.034662735,0.031213714,0.018208174,0.0630096,-0.056734506,0.04811314,0.08751329,0.005209697,0.022188846,0.0031978483,-0.009899775,-0.07174649,-0.076158226,-0.080655664,0.054804865,0.016323244,-0.07034525,0.06976261,0.079025336,-0.043204315,-0.013363044,0.00058940257,-0.02038072,-0.053258467,0.046539403,-0.04971614,0.017027142,-0.042889744,-0.044018153,-0.015938679,0.041652746,-0.061832953,0.044351913,-0.0644971,0.043340668,-0.034731034,0.037326436,-0.009102141,0.08916378,-0.055574264,-0.03602028,-0.0019593237,-0.046649538,-0.037872996,-0.05221312,-0.0951819,0.030384166,0.02008759,-0.014983038,-0.060605798,0.018228412,-0.020255713,-0.029658927,0.12657091,0.046928026 +2.4.1.214,"Requires Mn2+. The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. This enzyme catalyses a reaction similar to that of EC 2.4.1.68, glycoprotein 6-alpha-L-fucosyltransferase, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,3-linkage rather than an alpha1,6-linkage. The {iupac/misc/glycp#3.5::N-glycan} products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).",384,0.99999994,-0.024064502,-0.0037333746,-0.10139745,0.025794951,0.08529733,0.0022813643,-0.08982428,-0.0067156595,0.008564904,0.024462026,0.08428389,0.019222341,0.007006823,-0.037284534,-0.11385872,0.028448002,-0.048339874,-0.027531885,-0.031085724,-0.025136942,0.09782558,0.050035603,-0.029058969,-0.048418526,0.028106933,-0.0983687,-0.076716945,-0.061490346,-0.008945304,-0.100888304,-0.08034926,-0.039113116,0.04374794,-0.070639215,0.03520424,0.06952083,-0.015600587,-0.0011042149,0.04091123,0.03633491,-0.021982703,0.00095977256,0.023341132,-0.07871947,-0.12042939,-0.06617137,0.0020077138,-0.009693577,0.021449799,0.067736775,-0.01148306,-0.042335358,-0.04327084,0.0417269,0.06485303,0.018675512,-0.16503683,-0.01708305,0.03248369,0.067395166,0.018059542,0.050829872,-0.0027501946,-0.029653871,-0.02101969,-0.07019442,0.023405997,-0.040927235,-0.021988966,0.035402957,-0.01630935,-0.0076246145,-0.017541084,0.0064756363,0.053622548,0.05843941,0.013169793,0.05294276,0.046719365,0.002514296,-0.008840745,0.029158156,0.07127797,0.015675206,0.014823161,0.019349135,-0.069895126,0.10503723,0.026647536,0.04339183,0.08088875,-0.0460238,0.022342468,-0.0031085021,0.00090487464,0.030285714,0.01643358,0.032852985,0.02921499,0.0066327984,-0.011290706,-0.0054469137,0.010067011,-0.09371833,-0.040573236,0.019182915,0.016059505,0.07347997,0.0985863,0.011599537,-0.022643229,0.044668294,0.040430117,0.0033908486,-0.09161232,0.005374929,-0.0033588428,-0.11888815,-0.00054361456,-0.036396537,0.10510517,0.041091505,0.028967107,0.045803882,0.02659573,0.05382222,-0.052717898,1.3410268e-33,0.073592424,0.091474906,-0.00047586058,0.0057138633,-0.004473366,-0.07109875,-0.02372499,-0.03178616,-0.046783622,-0.008594935,-0.101755075,-0.013632357,-0.013638877,0.09848817,-0.025314122,0.07524984,0.057619758,-0.05885668,0.11434257,-0.003508558,0.012573507,-0.0070013376,-0.008093456,-0.08811385,0.08095267,0.077574134,-0.0058649657,0.017734764,0.08297369,-0.0072980574,0.07420212,-0.11896069,-0.040328935,0.029623548,0.08122495,0.038267806,-0.041646626,-0.06574206,-0.011789491,0.007739279,0.05450188,0.074435264,-0.06343966,0.04029212,0.06315147,0.01652375,-0.03452534,0.03644327,-0.0026608335,0.06262904,0.04897882,-0.0016889556,0.09107447,0.043549173,-0.068556294,0.028801082,-0.004558017,-0.044256423,-0.021868967,0.102264225,-0.03891858,0.029743472,0.04372308,0.010154939,0.040458035,-0.0219395,-0.109965645,-0.01774612,-0.04114624,-0.034885466,-0.0348809,-0.121222556,0.032819178,0.019094829,-0.0232419,-0.07693114,-0.021443712,-0.03492556,-0.02747724,0.020746494,0.016579576,-0.017660262,-0.044277444,-0.04159812,-0.047006473,0.024543714,-0.042926013,-0.10577931,0.031217856,0.06107152,0.031996675,-0.07131581,-0.04488827,0.0448773,-0.017600507,-3.3164968e-33,0.039679617,-0.07801437,0.105804525,-0.03122244,-0.102956936,0.03407984,0.053288974,-0.05178599,-0.018949583,-0.042616196,0.008392787,0.02783032,0.030963393,-0.06961651,0.03789237,-0.012405657,0.025111444,0.08760462,0.046055626,-0.020369356,-0.03580173,0.064152315,-0.007888348,0.006258416,0.0051429546,0.030683942,0.05534778,0.058760047,0.00844975,0.012669817,-0.02050634,0.009033013,-0.03215979,-0.066398054,-4.3836193e-05,0.0066147596,-0.07084819,-0.079970956,0.054689284,-0.025531955,0.06067657,0.047989044,0.023760865,0.025578912,0.05684451,0.08352969,-0.06338469,0.025406687,-0.0063966154,0.0145439105,0.007590784,0.027849013,-0.06259629,0.030824918,0.044350266,0.016769396,0.01703499,0.035091862,0.013472938,-0.065519355,-0.047615148,-0.02844084,-0.06931374,-0.0012576182,0.09020271,0.058090463,0.013012755,0.02452632,0.013441515,0.0557987,-0.0071983957,-0.04873753,0.014153852,-0.018606124,-0.010267816,0.0071458556,-0.083437964,-0.028847147,-0.001462193,0.0020057338,-0.015980111,0.012881241,0.074204996,-0.03683468,0.059569124,-0.061828505,0.08480763,0.15334192,0.0046089916,0.015761994,-0.020501012,-0.08270032,-0.018794691,0.04250672,0.017172012,-4.8015895e-08,0.041045535,-0.085049175,-0.056319423,-0.1125713,-0.045309022,-0.012662698,-0.05429979,0.0062823566,-0.0076458817,0.031538412,-0.016404739,0.064310275,-0.0034762947,-0.040173855,-0.008401075,0.04434616,0.016796999,0.058896948,-0.036612146,-0.014198316,-0.14275345,0.04293166,-0.11104086,0.09383501,0.012728782,-0.07699963,0.024478734,0.08354925,0.0051622484,-0.03786658,-0.03164022,0.038858373,-0.028884653,-0.04015277,-0.071523935,-0.0104513485,-0.026890716,-0.03635508,0.05409904,-0.0064771967,0.012112665,0.02399083,-0.024872506,-0.018292878,-0.06268007,-0.028861897,-0.02653319,0.05036516,-0.038776454,0.038159028,-0.0048800115,-0.03756326,-0.046465416,-0.08380868,-0.07425872,-0.060174823,0.011178418,0.0071250144,0.0036305315,-0.022043359,-0.016436378,-0.0076818196,0.12797613,-0.034453727 +2.4.1.215,"The enzyme from maize can use cis-zeatin and UDP-glucose as substrates, but not cis-ribosylzeatin, trans-zeatin or trans-ribosylzeatin. Unlike EC 2.4.1.203, trans-zeatin O-beta-D-glucosyltransferase, UDP-D-xylose cannot act as a donor.",384,1.0,-0.04663817,-0.017290266,-0.055132944,-0.042198427,0.013126515,-0.030756265,-0.04947456,0.06820702,-0.008162553,-0.029747035,0.06495288,0.03958129,-0.10213455,0.016932815,0.0087058805,0.011754959,0.0642188,0.05978027,0.01306844,-0.009310899,0.031306114,0.03366214,0.05305921,-0.04948465,0.049616132,-0.14840758,-0.016276158,0.048130076,0.022661522,-0.0564599,-0.065353535,-0.0012993226,-0.05273154,-0.023944248,0.05428616,0.0241453,0.040844794,-0.084660016,-0.012066999,-0.035087224,0.1010184,-0.030263985,-0.05416529,0.015491776,-0.06002488,-0.024475453,-0.026272712,0.04093251,-0.049301445,-0.05308972,-0.025353285,-0.0654614,-0.03912931,-0.04460836,-0.02931821,0.040618375,0.016902553,-0.02189056,0.004403779,0.0735466,-0.025882095,0.04254792,-0.018295666,-0.029200552,0.04912931,-0.035261672,0.02019629,-0.008853665,-0.01639419,0.008665952,-0.039115522,-0.09678332,0.0011274917,0.051394526,-0.026657904,0.009656455,-0.00089550554,0.009469567,0.07787372,-0.036815826,-0.014529738,0.0054141125,0.08492296,-0.061195653,-0.036469996,0.012616498,-0.039941024,0.14141615,-0.004928095,0.0077076014,-0.021696966,-0.010502543,0.0063880705,0.04085488,-0.028965091,-0.007504642,0.08714902,0.009861458,0.038556103,-0.023050195,0.051744066,0.055262648,-0.017031305,-0.006309134,-0.038390588,0.064855754,-0.03409533,-0.003154934,-0.043416556,0.03647256,-0.045999616,0.022486603,0.0074682552,-0.029653037,-0.07952786,0.008012744,-0.06667953,-0.06539889,-0.020479424,0.0119044185,-0.012958145,0.019837968,0.05622842,0.07972353,-0.0031440172,0.078962885,-0.048099544,5.530727e-34,-0.07113678,0.0652078,-0.005754716,-0.018653302,-0.05724851,0.00666462,-0.040012922,0.031598505,-0.099431194,-0.03882802,-0.09746656,-0.07478067,0.045335352,0.06919906,-0.02695148,0.017720193,-0.0027575758,-0.014784384,0.03625785,0.05219463,-0.0034922292,-0.01028261,-0.04911295,0.044447925,0.048234154,0.062408064,-0.08762293,0.002380298,0.061947506,0.0005350307,0.014975527,-0.041328974,-0.017693635,0.047131646,0.02911529,0.064143024,0.008714062,-0.07035944,-0.015752481,0.028295528,0.018265355,0.005461324,0.028370218,-0.024542252,0.054869298,0.030155666,-0.02952679,-0.022310004,-0.03163124,0.0045673805,0.030307556,-0.020265274,-0.06231302,-0.049661174,0.040872816,0.05282024,-0.0052208626,0.049128484,0.026677374,0.010151635,-0.06275032,0.05584354,-0.0437387,0.008635956,-0.04724246,0.058376923,-0.093960285,-0.09522005,-0.070283815,0.04775743,-0.022964215,-0.07752281,0.110678844,0.014244951,0.009448119,-0.051187556,-0.028391855,0.022209106,0.022189591,0.022545466,0.014235,-0.006680735,-0.049664456,-0.10902143,-0.035865825,-0.03027007,-0.052501775,-0.00800878,0.066701554,0.0710398,0.027927227,0.0015466696,-0.099894665,-0.048707347,0.05627152,-1.6641294e-33,0.08450467,0.05226602,0.04463507,-0.007029033,0.007152601,-0.023707652,0.040439375,-0.14936143,0.1251595,-0.010856242,0.0648898,0.011187821,-0.01451171,-0.112687044,-0.0044552,0.00018903552,-0.0884406,0.052053336,-0.010395437,0.0067072874,-0.09598417,0.09592487,-0.022902267,0.029114362,0.021309063,-0.024515498,-0.0112068895,0.048798732,0.10141619,-0.07646334,0.003688813,-0.050746836,-0.019586176,-0.0064870156,0.040792346,0.026988579,-0.011795417,0.08120758,-0.037131805,0.02197561,-0.05945287,0.10066915,-0.0067709186,0.040836282,-0.024198217,0.09750385,-0.029058425,-0.030463668,0.009580441,0.013273432,0.08230302,0.01974258,-0.02529396,0.02391577,0.006842858,0.018878395,0.09704648,0.024299862,-0.057394538,-0.0020163765,0.029740166,-0.03653142,0.03096519,-0.044999793,0.10423821,0.010803451,-0.01269681,0.038328487,0.0007543142,0.08433913,0.037853576,0.01042282,-0.023864808,-0.016003942,-0.0203847,0.04949667,-0.11861728,0.003393178,-0.06291779,-0.073540755,0.019084174,0.0154792955,0.047624096,0.054106254,0.09472287,0.015098057,-0.033359207,0.09499381,0.03047165,-0.023785004,0.006156171,-0.0660791,0.03774613,0.013462787,0.12113582,-3.5835953e-08,0.011736926,0.016870007,-0.024004973,-0.063362546,-0.009015376,-0.045620408,-0.020426722,-0.019265478,0.10605562,0.07779962,-0.12522067,0.106536195,-0.028799454,0.019487554,0.0032132673,-0.02174753,0.01900556,0.020509487,0.002182164,0.037286136,-0.07614005,0.054960098,-0.14810911,0.041043345,-0.051799547,-0.032001223,0.04762408,0.029208986,0.08963306,0.0010147231,0.014396767,0.043652352,-0.007577264,-0.025852753,-0.05790032,-0.015145291,0.04171716,-0.034141958,-0.020546218,0.044614695,0.09712182,-0.06383953,-0.03041948,-0.003962354,-0.03759575,0.008977375,0.021908363,-0.038694464,-0.0063451254,0.060182884,0.043593217,0.0032287226,-0.066994876,-0.11345464,0.01802926,0.018743146,-0.04232578,0.013417982,0.04404226,-0.03268566,0.0229242,-0.026861966,0.21568763,-0.08016758 +2.4.1.216,"The enzyme from Lactococcus lactis is specific for trehalose 6-phosphate. Differs from EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, in that trehalose is not a substrate.",384,1.0,0.019654904,-0.13979825,-0.05496158,-0.08658802,0.017910834,-0.0050580446,-0.036201455,0.030590259,-0.016268432,0.024662916,-0.0007360321,-0.037565332,-0.10112705,0.091000035,-0.0107350405,-0.08157284,-0.0726393,-0.026851859,0.06152209,-0.026149761,0.09935733,0.038803678,-0.02253148,-0.017385492,0.09969866,-0.053239975,0.035593804,0.0075044646,-0.0023958748,-0.01723936,-0.0661178,-0.054102916,0.011365947,-0.012234591,0.03029744,0.077222675,-0.021110697,-0.075177975,0.059711054,0.028637365,0.01953855,0.0021128687,0.032191947,0.006129296,-0.0154940775,0.009426334,0.01367009,0.06957256,-0.04251925,-0.014163937,-0.030018961,-0.05724563,-0.07114225,-0.006514479,0.03392103,0.04150285,-0.04015357,-0.014212858,-0.021304654,0.03773273,0.044421438,-0.0048087435,0.030369822,0.06609974,0.00044484725,-0.047529593,0.057291742,-0.083196126,-0.00041951658,-0.06391733,-0.111745074,-0.04434697,0.07789954,0.024221849,-0.0046715057,0.06964798,0.011169119,-0.08485963,0.01085997,-0.013453501,0.03371052,-0.05364335,-0.080322064,0.09765271,-0.0024373527,-0.10486796,0.09474881,-0.0355487,0.05041478,0.029637093,0.059465103,-0.010034283,0.03166747,-0.063902855,-0.05665013,0.01693581,-0.054913957,0.06045361,0.042462036,-0.06368888,-0.041814454,-0.005349178,0.02215637,-0.001981523,-0.031055037,0.03267985,-0.0212179,0.07383265,0.035911925,0.02638089,-0.019494979,0.059883177,0.053603392,0.017563429,0.0018103634,0.0375728,0.003571702,-0.130979,0.03849047,0.051012624,0.008345027,-0.0045323777,0.08566505,0.046929576,-0.033331353,0.07710528,-0.049702726,-4.3233554e-35,0.0136407195,0.052278254,0.09415425,-0.10037115,0.032854713,-0.02291835,-0.07581706,-0.011966594,-0.10142648,-0.015375001,-0.034260664,-0.011273127,0.05367844,0.04149899,0.06299828,0.03908271,0.016411731,0.050677642,0.006023245,0.044410516,0.0002572452,0.059845924,-0.040320765,0.0338158,0.05863484,0.01044406,-0.023012845,0.044418473,0.0008530876,0.012785602,0.03653447,-0.07363911,-0.03627764,0.02741003,0.04348935,-0.037953615,-0.020100653,0.016577186,-0.028710071,-0.032232292,0.049852006,0.05615738,0.043899436,-0.0143822795,0.023667378,-0.1201706,-0.09184844,0.065078266,0.02468012,0.018720778,0.015491773,-0.03873265,0.03107949,0.004751514,0.05948699,0.0018354423,-0.01622212,0.08556414,0.06983145,0.0355594,0.037161145,0.03456743,-0.035140894,0.036725923,0.0069094235,0.015946064,-0.010837348,-0.066957615,-0.07269693,0.075164884,-0.074478574,-0.0043619447,0.005496767,0.0033736695,0.042944998,-0.04698481,-0.010578023,-0.011412054,-0.06158843,-0.009123286,-0.035627995,-0.02111357,0.026488006,-0.03206469,-0.117718376,-0.038454015,-0.022058884,0.014846581,0.030988945,0.033252865,0.040928476,-0.010896625,-0.11529697,0.040904116,0.020753993,-1.4699492e-33,0.09036726,-0.06553466,0.052228343,-0.083629675,-0.07100971,0.014807926,0.08150752,-0.005062873,0.04699773,-0.075760804,0.09319291,-0.027240472,-0.026210535,-0.045782458,0.00083903,-0.026597884,-0.015370808,0.05054827,0.039999988,0.034991648,0.040382687,0.08987024,-0.038521677,-0.0027650648,0.07582218,-0.004892034,-0.015175905,0.096847095,-0.06527522,-0.019613113,-0.042962503,-0.009451746,0.022789894,-0.025260571,-0.13837558,-0.022415703,-0.023009576,-0.07501858,0.018360289,0.014942833,0.05616864,0.07313058,0.061319683,0.022838803,-0.023403648,0.024013864,0.023137167,0.0023919502,0.023686888,-0.024330914,0.0024080717,-0.024931878,0.042362824,0.0084079,0.033530418,0.060039137,-0.0150046935,0.03904424,0.01956272,-0.019541442,0.021243222,-0.022277933,0.025538972,-0.06742208,0.070247576,0.011364896,-0.09012845,0.01789029,0.01810585,-0.045370646,-0.024900574,0.02647694,-0.058936637,0.00630711,-0.047428824,-0.027925212,-0.116359785,0.024603205,0.03414379,-0.0028511751,0.007873351,0.07822963,-0.033253916,0.07690656,0.05283201,0.031597175,0.013325635,0.08451788,-0.010834332,0.024151497,-0.07708513,-0.08079023,-0.05488043,0.0320749,0.08612535,-2.9401e-08,0.09802832,-0.053683393,-0.04713565,-0.057548568,-0.0034532063,0.03889836,-0.03971756,0.008160258,0.07058222,-0.064675234,0.0005268441,0.08588547,0.019787028,0.010521781,0.022694064,-0.031195082,-0.09126649,-0.061732292,-0.027412826,0.030271497,-0.024790563,-0.051755596,-0.12594944,0.059978563,0.02579456,0.005668249,-0.019519366,0.068591,-0.09197609,-0.051157452,-0.0076447646,0.014974895,-0.012165658,-0.024057945,-0.004371402,0.055316318,-0.06459832,-0.04956223,-0.035635132,0.083019614,0.055817273,-0.09070567,-0.042967312,0.00836911,-0.04493746,0.0522836,-0.005280973,0.00014300001,-0.0029491358,0.018737104,-0.02758424,-0.00421028,-0.056208663,-0.038623232,-0.033161834,-0.0057685026,0.026650134,-0.09192476,-0.04206567,-0.019199517,0.14054699,0.015974998,0.19871025,-0.053197235 +2.4.1.217,"Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.",384,1.0,0.018027991,-0.02890253,-0.043968208,-0.07340225,0.026864173,-0.04392869,0.006818228,-0.034310497,-0.068564385,0.07375303,0.041465852,-0.05457818,-0.034023553,0.0016359112,-0.024664884,-0.045241605,-0.07629867,0.027717143,0.03032177,0.04952428,0.17692101,0.019501913,0.026506776,0.020051459,0.018252376,-0.04855434,0.06764761,-0.042423997,-0.07005924,-0.026930543,-0.07303971,-0.08116623,0.025693234,-0.091762275,0.10310437,0.10597857,-0.028729765,-0.009997148,0.04355729,-0.023315962,0.057775036,-0.079885215,0.0248422,-0.03135197,-0.060162418,-0.0018986395,0.030179808,0.03955765,0.047778707,0.02268478,-0.07292601,-0.0050584567,-0.05456122,0.022477584,-0.030634752,0.06910995,-0.06105097,-0.0064533288,-0.028069478,-0.07862826,-0.025504233,-0.006824978,0.039079454,-0.014911115,0.11150669,-0.024827495,0.05122239,-0.09460137,-0.0065614446,-0.013148197,-0.014105002,-0.023637136,-0.018877717,-0.00449776,-0.010413502,0.09477878,0.009931245,-0.07110894,0.017338999,-0.009547877,0.052561693,-0.00074477535,0.037550952,0.03978732,-0.03527417,-0.026944458,0.00051230105,0.0047709793,0.016306253,0.042233374,0.052148808,-0.009783318,0.06107883,-0.024071423,0.019504791,0.02877593,-0.022157378,0.116861776,0.07068771,-0.033410445,-0.048053913,0.02233345,-0.00037991148,-0.022880962,-0.04038651,0.026127644,-0.04091769,-0.0023465815,0.041300546,0.06527879,0.060011856,0.027406497,0.022619804,0.007931088,-0.037046686,0.0680853,0.009760312,-0.11295686,-0.07320677,0.0064166463,-0.0007961077,-0.012591475,0.03637693,0.016303627,-0.06665747,0.019167665,-0.07294286,5.304378e-33,-0.032287724,-0.0058109006,0.08872221,-0.031002678,0.044096455,0.006606139,-0.087578945,-0.072661154,-0.05732767,-0.030660465,-0.12761678,-0.049607463,0.015153311,0.07041083,-0.09763865,0.032145303,-0.012741367,0.085219756,0.06690053,-0.0033417512,-0.01622265,0.11078459,-0.00052953925,-0.023848329,0.06269426,0.117099516,-0.023495398,-0.048858687,0.020058492,0.009983629,0.09233385,-0.13378683,-0.059073433,-0.026816508,0.030411437,-0.0326817,-0.03753574,-0.059782576,-0.031495664,-0.015306054,-0.023450894,-0.012602557,-0.03567015,0.013625244,-0.0003480415,-0.050457638,-0.00561932,0.07396876,-0.014392305,0.08706325,0.03948846,-0.02873281,-0.003152961,0.040603757,-0.056435704,-0.023542637,-0.035201866,-0.052151836,0.12494517,0.03537938,0.06472105,0.063814424,-0.00063948135,0.033962548,0.014141635,0.029347103,-0.05869247,-0.02347582,0.02123251,0.061540756,-0.03423264,-0.08638285,0.013185275,0.050210487,-0.015392945,-0.030239329,-0.0074206493,-0.014884152,-0.04801007,0.016979795,0.023707978,-0.012630392,-0.009865822,0.03355165,-0.048783604,0.02850574,-0.048890498,-0.065648794,0.019235201,0.035966232,-0.013957417,-0.028641528,-0.09364929,0.05015255,-0.0697268,-6.310469e-33,0.11938785,-0.080909416,0.06462003,-0.06930062,-0.06649141,0.027126769,0.06859103,-0.008173849,0.043353852,-0.019992735,0.0851076,-0.023321655,-0.030452421,-0.09121072,0.045810107,-0.011650584,0.04317901,0.033132743,-0.0015249982,0.012655035,0.065355815,0.061522298,-0.02839336,0.025323706,0.04423386,-0.036296934,-0.008726622,0.09786278,-0.025332058,0.05498581,-0.036246125,0.06977231,-0.02426985,-0.06454073,-0.048704304,-0.008171796,-0.06437364,0.0138986055,0.0109486515,0.052136593,-0.019977055,0.040985707,0.0595517,-0.017482584,0.02906452,0.060052764,-0.016290767,0.03536753,0.0129361935,-0.00040112043,0.069319494,-0.026666878,0.025915034,-0.017348578,0.06882771,0.049922403,-0.054918326,0.035409346,-0.018859645,-0.047074165,-0.018409604,-0.09224092,0.07990924,0.0065889144,0.047528736,0.088546254,-0.019044591,-0.057104755,-0.006638008,0.06626865,0.003998068,0.028754614,0.037447706,0.042242285,0.00062659633,0.04959967,-0.10336072,0.009473792,0.07206748,-0.056398813,-0.007293125,0.03871567,0.04278568,-0.0348779,0.060194615,-0.037799995,0.03615963,0.061884817,-0.016534977,0.017271763,-0.060204294,-0.07281072,-0.049445298,0.009418925,-0.013468309,-4.2724484e-08,0.041411918,-0.007934241,0.056926854,-0.042180315,0.006832809,0.03924344,0.040227145,0.0068874247,0.051215548,-0.04689798,0.07635956,0.0047600158,0.030438915,-0.009046732,0.030837508,-0.012836085,-0.052459873,0.028074387,-0.062373158,-0.080097705,-0.065028556,-0.0017079628,-0.09472308,0.06870645,0.07418757,0.034384515,0.07256441,-0.0042940653,-0.07738977,-0.024565803,0.046226114,-0.0062621427,-0.032616396,-0.037269566,-0.061570562,-0.013884064,-0.12281248,-0.01252782,-0.05616311,-0.057456423,-0.060497012,-0.0028315482,0.057620626,-0.018065592,-0.0141302515,0.022124633,-0.059473637,0.04466786,-0.04021281,0.028597062,0.083737016,0.0038882627,-0.05680979,-0.05378259,-0.09249703,-0.04074456,0.040084917,-0.057062797,-0.08974417,-0.039580934,0.14469108,0.006025268,0.110197484,-0.06331414 +2.4.1.218,"Hydroquinone is the most effective acceptor, but over 40 phenolic compounds are also glucosylated, but at lower rates. ",384,1.0,-0.0055765742,-0.07458085,0.0072536697,-0.021360058,0.04531055,-0.0028331052,-0.0099673215,0.07532628,0.0021754242,-0.069644034,0.06050712,0.0498079,-0.08115543,0.04393993,0.0020015487,0.1126763,0.03553401,0.037194066,-0.044458922,-0.019761354,-0.054273233,-0.03862402,-0.0009976355,0.036445852,0.05478862,-0.001924116,-0.009711242,-0.0017812138,-0.019804006,-0.031556424,-0.050102845,0.0032898367,0.05421219,-0.021712089,-0.12554274,0.011250853,-0.07491161,-0.050500587,0.024386257,0.0142516475,-0.033275317,-0.07183997,0.01435172,-0.042507734,0.014245907,-0.10372302,0.014504777,0.066683054,0.049218334,0.017031422,0.010301607,0.0065164394,-0.06682675,0.09436497,-0.06424,0.023129523,-0.10920574,-0.015797531,-0.020342277,0.030392585,-0.020328863,0.027482467,-0.09407887,-0.0014124085,-0.089868516,0.026394324,0.011621367,-0.05625529,0.030011214,0.0039687664,0.034090426,-0.060848206,0.037911627,-0.036004703,0.013901828,0.06795982,-0.014690027,-0.02997914,0.07973088,-0.007918107,0.080872566,0.03276466,0.028166542,0.07574874,0.109516144,-0.008481605,-0.0642701,0.0924498,-0.004993318,0.037504617,0.0013879649,0.05146763,0.011011717,-0.0057461867,-0.0038645319,0.04560062,0.06842378,-0.050531242,0.03402759,-0.0018552862,-0.014786498,-0.03019019,-0.0381948,-0.094706126,-0.045870792,0.040044397,0.023181668,-0.023759577,-0.017765243,-0.026737705,-0.051167864,-0.021458289,-0.024428666,-0.037711423,-0.05662872,0.03882189,0.08341872,-0.02275097,-0.02886074,-0.0057987003,-0.07374353,0.025350567,0.105319075,-0.031426348,-0.051438656,0.012798843,0.057941977,2.3710803e-33,-0.025864057,0.05702898,0.009245003,-0.012558802,-0.032121096,0.08032219,-0.078853674,0.056667354,-0.023667037,-0.110210285,-0.10553391,-0.0058897743,-0.029972188,0.07352878,0.04540467,-0.020900486,-0.0046226284,0.04704762,0.053693675,-0.06070423,-0.007358094,0.048654877,-0.07384247,-0.0049973666,-0.04887309,-0.025550155,-0.024102604,0.061354246,-0.017986592,0.0005149089,0.012660194,-0.06325829,0.023416402,-0.0041685523,-0.08687131,0.040633097,-0.1291332,-0.04815874,0.031500753,-0.041741654,-0.051086616,0.06935466,-0.010893678,0.014742734,0.03912596,0.02954972,-0.01787615,-0.036125574,-0.067362815,0.07320505,-0.009389073,0.053540844,-0.0687566,0.042929705,-0.072087616,-0.020405123,0.070953,0.060399562,-0.00070427015,0.054901145,-0.04403307,0.09933096,0.037792794,-0.08623778,-0.012114217,0.02980647,-0.033460252,-0.005906289,-0.0969616,0.03188864,-0.0021767083,0.015135692,0.028692164,0.008051995,0.054946814,-0.077599935,0.059542593,0.015578714,0.019674841,-0.031020673,-0.09639481,-0.010337551,0.012595973,0.15619579,-0.1036504,0.06956921,-0.013987117,0.019541921,0.07451132,0.0144583555,-0.008112586,-0.061389677,0.013692658,-0.032484747,0.04470507,-2.2935664e-33,0.09414134,-0.09694522,0.08830411,0.09645026,0.07039685,0.00020844705,0.017753595,-0.10413311,0.096153736,0.02911937,0.059344362,0.025088605,0.039465666,-0.010937151,-0.0037418827,-0.014457014,-0.033046912,0.03579274,-0.038276486,0.014919205,0.01881399,0.0462459,0.053952064,0.0064910175,0.043181922,-0.006499352,-0.04107797,-0.07006481,0.077219404,0.079745986,-0.0343065,0.06980327,0.01019873,-0.054376323,0.06766303,0.052918114,-0.014692231,0.02036482,-0.0637046,0.060806356,0.045135934,-0.006109774,-0.05035743,0.04203897,0.038965214,0.07121693,-0.035126105,0.009347337,-0.013237577,-0.0013884947,-0.0020921538,0.06720782,-0.058944363,0.024457414,0.10064242,0.034402866,0.041068725,-0.1037311,-0.048051048,-0.042104535,-0.10035696,-0.034239,0.030847263,-0.045561325,0.019218346,0.034666456,-0.0133297555,0.119007185,-0.045986354,-0.030538868,0.08820183,-0.032634813,0.064262845,0.12555051,0.025002055,-0.03182715,0.027503937,-0.08252666,0.006450265,-0.007619579,0.010935149,-0.04404279,0.014460331,-0.003980603,-0.005911552,-0.017892988,-0.034598745,-0.06576605,-0.03893778,0.08239128,0.0208554,0.025919758,0.02315916,0.00505398,0.070701726,-2.571413e-08,0.0055951905,-0.0563181,0.06380002,-0.022594018,-0.022317238,0.012174534,-0.03777767,0.08235993,0.016888626,-0.043130964,0.02625189,0.04166306,-0.018804172,-0.0016086779,-0.047220353,-0.023856563,0.01987559,-0.01883215,-0.043885645,-0.015519147,-0.1012738,0.05725369,-0.007128746,-0.12086082,-0.0032677338,-0.048257142,0.05878699,0.026493968,-0.010043724,-0.027714316,0.021959284,-0.015595322,-0.046212442,-0.013639595,0.0488481,0.07920206,0.016564235,-0.018174496,-0.08110915,0.025290793,-0.019971322,-0.066022694,-0.06666877,0.03521334,0.051282987,-0.016016735,0.025388181,-0.015418089,0.00680518,0.032108866,-0.002362798,-0.025825012,0.06158037,-0.054114264,-0.067086376,0.025194442,-0.01712342,-0.030985048,-0.01759965,-0.11806396,-0.04948035,-0.022106027,0.1474666,0.025719892 +2.4.1.219,The indole alkaloid raucaffricine accumulates during the culture of Rauvolfia cell suspensions.,384,1.0,0.0023573898,-0.07256689,-0.12190428,0.021676846,-0.03283139,0.07857076,-0.06641594,0.012799098,0.0060044294,0.007603662,0.033467073,-0.060244624,0.013712032,-0.029108642,-0.13543622,0.06616801,-0.017789582,0.018536748,-0.064244054,-0.041385304,-0.0083605135,0.05392712,0.03653768,-0.024591899,0.08053576,0.005715952,-0.024986131,-0.03136043,-0.012970761,-0.025540596,0.03690205,0.059419323,0.008975904,-0.031137543,0.00018962989,0.029305818,-0.08875183,-0.012297322,0.09423982,0.07598418,-0.00670201,-0.041446168,-0.084572926,0.043478772,-0.053975392,-0.0144070005,0.007904768,0.013106634,0.092394866,-0.072007895,0.0017410896,0.0408339,-0.07843717,0.057168208,-0.06329613,-0.023949703,-0.0076130833,0.04594649,0.008860596,0.092963606,0.0014567879,0.040012967,-0.03408662,0.02059761,-0.054544654,-0.055781614,-0.043314405,0.037362278,0.07224409,0.026222,0.027107703,0.0067320997,0.04018723,-0.015998561,-0.013137172,0.077072315,0.038549118,-0.0056322687,-0.058457147,-0.03029892,-0.0013450525,0.0019834659,0.07568809,-0.020256886,-0.015887467,-0.028539423,0.07718412,0.021519952,-0.017648878,0.029890327,0.066128775,0.07010579,0.03849223,-0.08655241,0.039837502,0.03888185,0.039916217,-0.04631153,0.0033579643,-0.058017496,-0.026564902,-0.045503784,-0.029817322,0.05608717,0.010553696,0.00071892136,-0.032193232,-0.095556885,-0.06685943,0.061817303,0.015816431,-0.025615169,-0.07006866,0.03504616,0.04075379,0.0790724,0.029979702,-0.08400299,-0.06942678,-0.04596536,-0.025843386,-0.031892102,0.043494407,0.006160051,-0.0061755157,0.018920757,0.03789215,2.0152627e-33,0.03908096,0.017912718,-0.1295874,-0.011152256,0.0372296,-0.024980858,-0.046244454,0.0314634,-0.00052272395,-0.023515288,-0.03926545,0.06691223,0.020891579,0.03864424,-0.06013718,0.011425032,-0.014152343,-0.017437454,0.015344295,-0.03292725,-0.08288947,0.008851735,-0.008004846,0.012952031,-0.11994721,0.0056142905,0.009039403,0.012158995,-0.0078069963,-0.034972906,0.047768954,-0.048518337,-0.047008306,-0.0011401292,-0.07449504,0.10271671,-0.047716774,-0.026429258,-0.041725114,0.0837601,0.02079896,0.10842258,0.05713275,0.040679846,0.07381969,0.035332598,-0.069864824,-0.008592963,-0.001934689,0.043080505,-0.04350749,0.013337502,0.119028196,-0.06056819,0.0018300796,0.013126663,0.041821185,0.021222489,0.017158333,0.0030594366,-0.03905912,0.0011281522,0.014042642,0.1059066,0.015712986,0.024753274,-0.07669582,-0.065798916,0.02424653,-0.025004076,-0.050684333,-0.0198872,0.018249683,0.053716328,0.037395824,0.008591583,0.046065256,0.055905294,-0.067058824,-0.029161328,0.054412346,-0.024056394,0.006266356,0.024602758,0.03742781,0.01442323,-0.058029443,-0.064837106,0.04441247,0.023826992,0.040719274,-0.03282369,-0.11348919,0.07995799,0.049213164,-1.6602333e-33,0.13307756,-0.07513575,-0.0454964,0.009651759,0.0054533104,0.09479964,-0.021548616,0.11445167,0.0034260913,0.013253012,0.06326414,0.031074543,-0.014696067,0.04201131,-0.02412815,-0.124119595,0.121956475,0.10879455,-0.026967341,0.048166025,-0.13041544,0.08949492,-0.027795233,-0.003138173,-0.010876376,-0.064283624,0.022193754,-0.016499652,-0.100848705,0.016388655,0.06465046,-0.025376333,-0.08691413,-0.03862776,0.03015186,0.012739248,0.015446658,-0.010797576,-0.0034963454,0.06641614,0.03453244,0.036281943,-0.017575469,-0.007704067,0.024467427,0.014378867,0.0072958674,0.02502176,-0.039329857,-0.048583105,0.035686355,-0.09729126,0.061269954,-0.029693557,0.066487156,0.048140362,0.11036178,-0.019406928,0.025898265,-0.041639615,-0.014501223,-0.015697652,0.047823522,-0.09572772,-0.024371563,0.11175355,0.052248076,0.05105039,0.0080786375,-0.0006683726,0.0456679,0.024936523,0.04009183,0.046078455,-0.07802551,0.0037491645,-0.015675358,-0.07190519,0.008224821,-0.02092905,0.051918916,0.0023418288,0.007347413,-0.09865119,-0.0061129075,0.0077914144,0.015161419,0.07718647,0.008908032,-0.0422071,0.07426636,-0.059857674,-0.108769976,-0.0049559292,0.1384752,-2.1464757e-08,0.041884836,0.015099434,-0.008023903,0.06456793,0.015899977,0.034710616,0.06669483,-0.01733075,-0.0028782764,-0.044168446,-0.07785188,0.087055326,-0.04352027,0.048164133,-0.04797543,0.05531725,-0.02716672,0.023757039,0.039092623,0.06370437,-0.035860002,0.008091556,0.09660636,-0.014140901,-0.007928251,-0.07050654,0.049385004,-0.05901085,0.06815395,-0.08901811,0.11393452,0.031169353,0.041676782,0.002231429,-0.02414543,-0.03912432,0.03605714,-0.0415248,0.050781928,-0.023914568,0.004168417,0.0060986103,0.009482799,-0.043690793,-0.016131913,-0.0029294433,-0.026759315,0.0012072411,0.011857813,-0.09205509,-0.019336043,-0.027584324,0.031550344,-0.036533777,-0.048449337,-0.099451005,-0.047582056,-0.043963026,-0.008803398,-0.07777269,-0.06280457,-0.028256768,0.047407508,-0.019394359 +2.4.1.220,"Also acts to a limited extent on 4-, 5-, 6- and 7-hydroxyindole. After enzymic or chemical hydrolysis, indican forms indoxyl, which, in turn, is converted in the presence of oxygen to the dye indigo.",384,1.0,-0.03522543,-0.13257597,0.029958935,-0.028200654,0.08978553,0.019897861,0.05683502,0.007323529,0.007498746,-0.005747479,0.036589865,0.037647583,-0.08936047,0.024045764,-0.05362478,0.16122995,-0.06408723,-0.0077631446,-0.12328307,-0.028435081,0.08905043,-0.049947165,0.03219005,0.03432077,0.031556755,0.014105214,0.08735337,-0.00484415,0.02073103,-0.09579395,0.045677006,0.008124728,0.025158158,-0.02138672,-0.01080871,-0.023775844,-0.005173388,-0.0625544,0.048441596,-0.03941447,0.041514594,-0.057991255,-0.052148715,-0.028588872,0.016439766,-0.06367915,0.038796946,-0.0038212284,0.022817539,-0.028517453,-0.006015285,-0.032058943,-0.09220033,0.027135044,-0.0076121883,-0.005812544,-0.054675974,-0.024848718,-0.02206419,0.033827476,0.0010320066,-0.00058488065,-0.01820575,0.07199437,-0.07425308,-0.013876785,0.046872567,0.0011121614,-0.03287426,-0.013800056,-0.019802539,-0.08484668,0.01645561,0.021972207,-0.004755534,0.036452025,0.0148904845,0.012271865,-0.0054200697,-0.033388928,0.0073604793,0.06772639,0.03955793,0.11539525,0.0015696831,-0.033053882,-0.0022784816,0.031827725,-0.044553533,0.036592174,-0.002827001,0.060512807,-0.047591448,-0.033136353,0.036541115,0.036031727,0.093318924,-0.03126364,0.058339074,-0.0075910077,0.013695253,0.039907847,-0.03656052,-0.118179895,-0.13908339,-0.05306774,0.05547688,0.02115177,0.06277519,0.019955408,-0.021186149,-0.06931665,0.045131914,0.042693213,-0.08626531,0.038480565,0.027499957,0.0011379572,-0.069332905,0.0029319292,-0.061355058,0.008439945,0.067021534,0.090521835,-0.15409109,0.0873918,-0.057005838,-1.7011027e-33,0.037190177,-0.0565573,-0.025237972,0.0036940223,-0.006655174,0.02286062,-0.083525,0.03938847,-0.049245168,-0.053179614,-0.036543507,-0.009801654,0.026114624,-0.02659077,-0.037348356,-0.018644989,0.005729771,0.053634997,0.03211315,0.029629327,0.010591668,0.06840265,-0.10662572,-0.011427615,-0.0860257,-0.013056644,0.014558702,0.05429795,0.041077774,-0.0154229,0.069321536,-0.036348596,-0.049632084,0.0019847825,-0.024819084,0.043042514,-0.011348454,0.025914725,0.024051143,0.09632481,0.0021494422,0.066426374,0.028148647,0.015267045,0.04957704,-0.0022334245,-0.0008553778,0.11004218,0.049317453,0.030574596,-0.04640408,0.02384238,0.10598598,-0.008778567,0.050789196,0.0865732,0.02377056,-0.01868888,0.029879991,-0.022062903,-0.03450452,0.037922863,-0.024476737,-0.018167442,0.013540247,-0.0025471319,-0.07154832,0.01029961,0.012184733,0.019319989,-0.047167443,0.039906368,-0.0052497727,0.07070125,0.017657664,-0.027604854,-0.037688956,-0.013129356,0.010632971,0.022841353,-0.003750221,0.05777322,0.054011006,-0.054015692,0.023692865,-0.0152862845,-0.08301777,0.03686777,-0.051630594,0.007293497,0.07496103,-0.13380902,-0.0744015,-0.054151386,0.0021418422,-2.539543e-34,0.018461129,-0.08574256,-0.104584366,-0.017877044,0.036194213,-0.000102588725,-0.0077505023,0.05903176,0.049471024,0.055739515,0.099199206,0.039516944,0.0489046,0.03263197,-0.021972155,-0.016026745,-0.032039803,0.098536186,-0.007051225,-0.038303155,-0.039281145,0.017286945,0.035943817,0.016588166,0.0038341999,0.072877124,0.019828957,0.030393517,0.026060624,0.078846,0.03216134,-0.054659836,-0.06783822,-0.015506774,0.048653096,0.0077595618,-0.01881823,-0.046635374,-0.05405301,0.06526202,-0.07242011,-0.017064823,0.056058176,0.017756963,0.01199898,-0.01424032,-0.089937784,0.037929967,-0.0048683765,0.021161696,0.01764025,-0.0028866162,0.015859205,0.041476496,0.0024650933,-0.069262326,0.004972284,0.044321667,-0.058021255,-0.02149343,-0.026398707,-0.08595587,0.03860737,-0.026992755,-0.060813986,0.059027124,-0.04339972,0.08962877,0.007752753,-0.1324343,0.059023127,-0.059387397,-0.028915606,0.013168524,0.03416207,-0.057167914,0.051544067,-0.086696215,-0.04883173,-0.0335881,0.0016195117,0.024553904,-0.038144358,-0.17699052,-0.02182204,-0.006051951,0.037580054,0.074187145,-0.0019505642,-0.009111347,0.02122964,0.04270158,-0.0610228,0.033039723,0.009038391,-3.511711e-08,-0.07424871,-0.08908359,0.1275447,0.06673473,0.0042702495,0.02962092,0.04254363,0.0067189257,0.027051115,-0.054361925,-0.01955678,0.08438529,-0.0010699392,0.024805678,0.060738757,-0.06254465,0.030702129,0.039518964,-0.03389633,-0.036258847,-0.08794258,-0.0077662445,-0.04198903,0.055402827,0.015294619,-0.067712165,-0.026162293,-0.07094175,0.016987849,-0.004854958,0.056874793,0.06158775,-2.4971118e-06,-0.03578786,-0.12962273,0.036953818,0.0034935104,0.0004887062,-0.07755073,-0.014462331,-0.051543664,-0.043133654,-0.020264274,-0.018249888,0.026003197,-0.0480794,0.0063606026,0.07894814,0.012173553,0.005441937,-0.0003030137,-0.06444564,-0.0021789076,-0.04453516,-0.039692976,-0.076486595,0.00928063,0.05341477,0.04150029,0.01897055,-0.0291899,0.00945156,0.18734378,0.0042254883 +2.4.1.221,"The enzyme, found in animals and plants, is involved in the biosynthesis of O-fucosylated proteins. In EGF domains, the attachment of O-linked fucose to serine or threonine occurs within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys. The POFUT3 and POFUT4 proteins modify EMI domains.",384,1.0,-0.0049129375,-0.04113233,-0.08546408,0.013704393,0.10350042,-0.007563329,-0.00050951546,0.061767817,0.1178879,-0.018890884,0.10285428,-0.022606952,-0.08118859,0.012806611,-0.00906011,0.03932245,-0.10928205,0.054407656,-0.00335377,-0.10850009,0.06182022,0.029733056,0.01771427,-0.045805436,-0.0156556,-0.07648854,-0.052608576,0.008153647,-0.014082584,-0.111470655,-0.002567969,0.0066807913,0.01757413,-0.0052600377,0.009263869,0.04606531,0.018145341,-0.091712065,0.003088351,-0.022100596,0.04130148,-0.067115605,0.02764886,-0.08113648,-0.02700619,-0.027399186,0.04350084,-0.004372937,0.0030293786,-0.017031843,-0.019510452,-0.06484054,-0.045144185,0.026354805,0.0349222,-0.020976832,-0.0066119037,-0.014447149,-0.022758206,0.0025888185,0.004140896,0.022209864,-0.03181264,9.79652e-05,0.022509247,-0.071050435,0.02544019,-0.05982767,-0.09139249,-0.012757147,-0.035070546,-0.04434577,-0.0032538224,0.01650254,0.061867714,0.16154405,-0.07725374,0.036319017,0.03527225,0.007977721,0.09386958,0.07146787,0.0020744507,0.107459605,0.008939335,0.033292864,-0.02600043,-0.022211427,0.004907222,0.08754452,0.015727406,-0.062695995,-0.030335335,0.023823716,-0.018634956,-0.02043224,0.058699075,-0.0463361,0.023222653,-0.04113232,-0.06417001,0.039137468,0.02275623,-0.015338613,-0.021325355,-0.005840341,-0.07019889,0.1059302,0.026665369,-0.050194565,-0.04964629,-0.023523297,0.11037568,-0.019173816,-0.03306636,0.066044345,-0.010929028,-0.04646122,-0.015575978,-0.038610984,0.012028189,0.051230174,0.0026969286,0.15524627,0.0018899763,-0.010736798,-0.12629907,1.8939381e-33,0.0597824,0.05296328,0.041775037,-0.015440331,0.010143778,-0.04186197,-0.00966544,-0.05146574,-0.020407077,-0.030978478,-0.08119279,0.00026953107,0.0507658,-0.028997893,0.005905645,-0.06884343,0.0013891149,0.03601283,0.051975265,-0.008105916,-0.022174533,0.03769452,-0.06318216,-0.012635794,0.013780004,0.048363235,-0.04802349,0.010202667,-0.023347275,0.0074316002,-0.02748005,-0.0937981,-0.013732487,-0.0072305244,0.0815221,-0.03942557,0.008584808,-0.08243547,-0.009324373,0.013249496,0.037164718,0.0036116831,-0.04058226,0.010275579,-0.0026856798,-0.011437496,-0.08476677,0.09593471,0.06222386,0.05990138,0.09549787,-0.045534544,0.1032196,0.0014958765,-0.024331171,0.017545983,-0.093434654,-0.029812463,-0.010695046,0.03450029,-0.026502928,-0.060269676,-0.05379165,0.036682915,-0.013699893,-0.051622298,-0.04411207,-0.084168784,0.004070097,0.16009445,-0.013360317,-0.046636686,0.061383918,-0.017000489,0.013373429,-0.043424577,-0.09479144,0.08669316,-0.013537717,0.03422923,0.030418716,-0.027892949,-0.089458205,-0.027442072,-0.06538132,-0.019346306,0.0029992997,0.022949703,-0.010004932,0.01079345,0.03089474,-0.08681623,0.04148591,0.033101134,0.043347526,-3.2447637e-33,0.025518108,-0.047874562,0.06016531,-0.039151967,-0.047510915,0.051635835,0.005908127,0.046468295,0.008041997,-0.0015046225,-0.010528618,-0.009865243,0.053125758,-0.07734141,-0.0031167818,-0.022597717,-0.020945275,0.040177487,-0.016584087,0.019954244,-0.05962503,0.0064081685,0.0676793,0.034068376,0.03805847,0.078670226,-0.021005545,0.027604047,-0.07760482,0.045219984,-0.016497366,0.04672751,-0.016376829,0.015905758,-0.027341302,-0.028374976,0.0644469,0.0038913698,0.04822497,-0.02651079,0.02472549,0.0626127,0.07345031,0.084411204,0.02065479,0.14241774,-0.057023954,0.06281496,0.021806182,0.02233326,0.013803323,0.074445605,0.0010406334,-0.009731813,-0.029028844,0.0618674,0.058858838,-0.048872724,-0.020616563,0.009119786,-0.030622777,-0.087762095,0.039998844,0.056442764,0.005423386,-0.0017758365,-0.02156498,0.031817313,0.07222932,0.006609773,0.026186299,0.03237552,0.005993273,-0.011865748,-0.049715396,0.033597372,-0.045630798,-0.053877722,-0.018073345,0.037842922,-0.07405583,0.044196345,0.0025473833,-0.053875174,-0.026210392,-0.050649524,0.0245562,0.11940465,0.04591573,0.04249901,-0.057924394,0.014139784,-0.033839066,0.031749766,0.05889743,-4.3185718e-08,-0.023198413,-0.105486944,0.012759121,0.024104038,-0.05302258,0.019027462,-0.01155119,0.040729012,0.03811793,0.0334416,-0.046543837,0.08962617,-0.024242213,-0.007351712,0.062247608,-0.02193419,0.037551075,0.040861987,-0.021861413,-0.04799406,-0.077988,0.03072446,-0.037784304,0.07421893,0.019642362,-0.086802356,-0.008767971,0.041245367,-0.025728902,0.0129630985,0.02651333,-0.0013254423,-0.006111632,-0.023556545,-0.12984504,0.0033662443,0.0069963005,-0.089312345,-0.059049275,0.020965127,-0.016937751,-0.017940208,-0.019551117,-0.057970323,-0.03885183,0.075728506,0.026331503,0.041543912,-0.0073254243,0.0064315572,-0.012529667,-0.034984875,-0.03625917,-0.106704764,-0.11700624,-0.023198003,0.0076165935,-0.014471102,0.087113574,-0.044122946,-0.059233017,0.046504594,0.23076652,-0.03413618 +2.4.1.222,"The enzyme, found in animals and plants, is involved in the biosynthesis of the tetrasaccharides alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc and alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc, which are attached to L-Ser or L-Thr residues within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys in EGF-like domains in Notch and Factor-X proteins, respectively. The substrate is provided by EC 2.4.1.221, peptide-O-fucosyltransferase.",384,1.0,-0.046569698,-0.05211011,-0.112811685,-0.012845835,0.056277666,0.019536536,-0.041848965,0.048312373,0.12502708,0.076436915,0.116394676,-0.029429654,-0.0524178,0.010987176,-0.07888679,-0.028218923,-0.052610595,-0.014790208,-0.017599802,-0.08262016,0.029322742,0.025542324,-0.02123901,0.01360015,0.01844847,-0.09825427,-0.079858966,0.0045137806,-0.013946945,-0.05565345,-0.028414954,-0.019494122,0.022439934,-0.03280697,-0.036798112,0.078254916,-0.030940266,-0.0560362,0.024318796,-0.004881956,0.00039445018,-0.05308257,-0.0032791693,-0.04656994,-0.0042680698,-0.0228737,-0.053706024,0.058489703,0.049747728,0.030132974,-0.011649884,-0.06388562,-0.06757279,0.053600572,0.028527291,0.013476776,0.006131208,-0.005984311,0.013184403,0.13491723,0.017501067,0.046205785,-0.015811425,0.023020461,-0.081017144,-0.03649434,0.008969202,-0.079129316,-0.020173918,0.01265247,-0.041395307,-0.070602536,0.016481379,-0.011979735,-0.0008666793,0.09597508,0.006700568,0.018892974,0.0033577706,0.059862174,0.040262915,0.07583832,-0.0018851873,0.069757365,-0.021078495,-0.033017635,-0.045860182,-0.019183313,0.03845938,0.0564796,0.07364514,-0.018022494,-0.03419409,0.0355684,0.03615439,-0.040374447,0.044531133,-0.004122938,0.050569877,-0.05703894,-0.052053124,0.021648329,0.02952694,-0.07127775,-0.046484496,0.03876901,-0.039170083,0.08439828,0.060736567,-0.0060804486,-0.055712525,-0.0034200342,0.050428595,-0.011960143,-0.07012176,0.08695517,0.019034537,-0.11473244,0.0010904964,-0.03923321,0.017879609,0.009128821,0.045960408,0.105939545,0.039857116,0.059219606,-0.076159604,-2.6177412e-33,0.08157115,0.058894962,0.0477344,0.05428885,0.039075382,-0.019503765,-0.04007664,-0.02988429,-0.05640098,0.024684036,-0.08594629,-0.022193035,0.011818638,0.021736387,0.048498094,0.0022743638,0.026068361,-0.10246014,0.038240477,0.046753477,-0.06356155,0.02168715,-0.015430402,-0.04905509,0.065776125,0.08757668,-0.04149986,-0.017847475,0.01865082,0.0025952219,-0.0231673,-0.0916207,-0.06140227,0.024027972,0.13471633,0.00061485084,-0.01176848,-0.035800166,0.031107122,0.035340544,0.10463927,0.060186304,0.038317457,-0.01895418,0.024084242,-0.024158003,-0.022758797,0.05433048,0.01223443,0.07473573,0.1126092,-0.0018511353,0.10537219,0.057230804,-0.052607663,0.02360698,-0.11612599,-0.009535025,-0.0033869569,0.06725961,-0.05124054,-0.031870287,-0.029532801,0.0254789,0.01766502,-0.0146721555,-0.083509184,-0.05680482,-0.038220428,0.035753153,-0.033952005,-0.10332174,0.097604424,-0.030819822,0.032499142,-0.00510371,-0.06956573,0.047563806,0.014080316,-0.00594901,0.045878753,0.055990007,-0.03776348,0.00010545021,-0.025257776,-0.019933717,0.012851024,-0.025362357,0.01401079,0.004613114,0.035036463,-0.054797146,-0.0288959,0.06189314,-0.0037722334,-1.2880966e-34,0.048087545,-0.1330847,0.0529607,-0.038430247,-0.04352192,0.011842723,0.010075899,-0.06285001,0.031663895,-0.07160468,0.045701362,0.03602995,-0.01762532,-0.04742214,-0.009091386,-0.020444995,-0.022073202,0.09335723,-0.055910867,-0.008525575,0.004360194,-0.009483621,0.042885385,-0.032686505,0.057430547,0.01807858,0.04830945,0.03974922,-0.011149617,0.016910879,-0.018531524,-0.0046524885,-0.045926455,-0.05237371,-0.02739172,-0.033717744,-0.05703563,-0.026440969,0.07492278,-0.0010944289,0.09075462,0.09560648,0.077097125,-0.044016555,0.043903597,0.11938422,-0.051503044,0.058886945,-0.038491122,0.013523547,0.028944155,-0.018178472,0.01369915,0.08263276,-0.010979027,0.06272823,0.07187714,0.06561546,-0.002026406,-0.0021420093,0.036534104,-0.04364436,0.01733776,-0.0039714123,0.00780565,0.021818047,0.022660937,0.0007060424,0.023160582,0.0029158967,0.029530784,0.0043227584,-0.051636636,-0.0034177029,-0.027164297,0.004860695,-0.11054122,-0.05527492,-0.015304023,0.004531892,-0.015689772,0.034675132,0.015247986,-0.012361369,0.03332043,-0.026055992,0.02086053,0.15489392,0.010717981,-0.012292225,-0.039756563,-0.043431133,-0.06266081,0.033809405,0.1355438,-5.3614727e-08,0.015370194,-0.04885237,-0.056826442,-0.08546041,-0.030697789,0.010880084,-0.0020477048,-0.013828827,0.008921302,0.028185785,0.059235554,0.10824286,-0.07655216,0.013454701,-0.01617103,0.012339464,0.060382623,0.047196623,0.026191307,0.010257622,-0.0748073,0.013238533,-0.07574856,-0.009436469,-0.028503424,-0.1586392,0.01024013,0.097281955,-0.021280318,-0.04755448,-0.008140511,0.021588435,-0.008873041,-0.07223661,-0.041178532,-0.00425149,-0.059833735,-0.04891469,-0.006097569,0.011856335,0.0081472015,-0.025778506,0.0023736795,-0.053120755,-0.061213292,0.013445159,0.033470176,0.08854566,-0.010030703,0.08422713,0.00885066,-0.000223673,-0.058515403,-0.11809969,-0.1041734,-0.06416396,0.014692167,-0.02384596,0.049839906,-0.074024804,-0.048536777,-0.031857878,0.11849901,-0.050401337 +2.4.1.223,"Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core. Apparently products of both the human EXTL2 and EXTL3 genes can catalyse this reaction. In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase. For explanation of the use of a superscript in the systematic name, see {iupac/2carb/37#372::2-Carb-37.2}.",384,1.0,-0.11586248,-0.025675943,-0.068947755,-0.036715902,0.0058239447,0.01355305,-0.06381409,0.07738488,0.027602091,-0.027066967,0.05805822,-0.038208954,-0.021959372,-0.0026567616,-0.11177446,0.00083171827,-0.050252672,-0.019189123,-0.017020172,-0.104336195,0.053166114,0.061523743,0.031668168,0.0012060372,0.012798347,-0.035528924,-0.029703459,-0.0727772,-0.02749949,-0.029880608,0.019176036,-0.102715164,0.028001178,-0.023202335,0.04558266,0.08552626,-0.030176546,-0.040359247,0.0016128067,-0.07186784,0.022780497,-0.068723485,-0.020955099,-0.02250555,0.00016014617,-0.033687886,-0.013188799,0.008579795,0.021897621,0.032873757,-0.005305239,-0.059539963,-0.039746836,-0.009392199,0.09205414,0.045495022,-0.09882203,-0.057343334,0.027162453,-5.29782e-05,-0.015280699,0.00063595397,0.013974715,-0.05924663,0.00747871,0.019009698,0.09321514,-0.05114156,0.022464635,0.02770795,0.0022548563,0.033111416,0.01977917,0.063619286,0.084665865,0.013324489,-0.043412212,0.0014569837,0.029188512,-0.05829348,0.01715739,-0.013110905,0.045431178,0.057697244,-0.05398309,0.009706886,-0.030070059,-0.007150966,0.023269128,0.07459859,0.006566074,-0.089871995,0.018610884,0.02735683,-0.009666548,0.07184822,0.033459615,0.048455585,0.02660799,-0.044679042,-0.022160541,0.021006208,-0.0016820126,-0.133926,-0.03245345,-0.01551354,0.0024298162,0.1065326,0.0070821177,-0.016695816,-0.010230538,-0.053345732,-0.017221054,-0.050613403,-0.10189297,0.11799533,0.0060213385,-0.017194707,-0.01382369,-0.02906974,-0.00033570195,0.11698438,0.018398568,0.08264746,-0.014373675,0.024131149,-0.09568292,3.8893255e-33,0.061310902,0.052495833,0.049887154,0.054599922,-0.04145483,0.012978144,-0.091619365,0.0207195,-0.0019778134,-0.039489184,-0.084098205,-0.0615717,-0.0069632893,-0.012816307,0.007176771,0.011125244,-0.05502387,-0.067425326,0.024562957,0.038718533,0.031361893,0.046734773,-0.0049852547,-0.02094722,0.010982145,-0.01766863,-0.028101368,-0.003736147,0.03860557,0.014795782,-0.009979509,-0.059794664,-0.027969046,0.07203651,0.046537843,-0.011393931,0.0017401866,-0.08651179,0.044841126,0.13209426,0.060476013,0.07100894,-0.011077977,-0.050774023,-0.011398032,-0.045957766,0.027562065,0.10280686,0.05174394,0.047866296,0.08914184,0.0008963894,0.14130287,0.016635953,-0.049331795,0.038090564,-0.040176604,-0.03650632,0.024689754,0.063731804,0.012119292,0.05517276,0.049043432,0.050952416,-0.04196431,-0.05951011,-0.082542695,0.010952672,-0.1040849,0.059522472,-0.009854593,-0.03153567,0.09705913,-0.0032558204,0.07687935,-0.059915222,-0.061041456,0.049935885,-0.087984815,0.06895298,-0.064532824,0.032477856,-0.013970064,0.02123318,-0.045571405,0.08711363,0.027919112,-0.081676126,-0.009843368,0.087452434,-0.059457548,-0.050792467,-0.07259695,0.025221774,0.053862493,-6.081331e-33,0.027057473,-0.05692582,0.04556949,-0.030293401,-0.066194996,0.04537357,0.031167608,-0.06260912,0.08350633,0.02923432,0.06137413,0.09567374,0.10440046,-0.09717265,0.030890787,-0.051899936,-0.03846967,0.05274986,0.016039727,-0.050084583,0.014523164,0.03895027,-0.054495163,0.004470387,0.08442618,-0.030802695,0.007651601,0.12311457,-0.02021349,0.049285635,-0.035762753,0.0041792705,-0.03199407,0.02517762,-0.0458473,-0.0024658323,-0.023564192,-0.053954337,0.011289514,-0.051232725,-0.023824446,0.03789068,-0.018648136,0.07080974,0.020630317,0.15215513,0.021554882,0.03479521,0.01874632,-0.029278751,0.015903706,-0.0029598735,-0.043942157,0.026765114,-0.00077929394,0.008730838,0.02551568,0.030028611,-0.008418684,-0.0016419867,-0.019195551,-0.05471954,0.0031663901,0.0063252947,0.030663028,-0.013503154,-0.012948124,-0.050840247,0.02864804,-0.05132466,0.025799947,-0.076473795,-0.031906024,0.009999689,-0.0033714017,-0.002803614,-0.053631,-0.06166503,-0.02529493,-0.13813396,-0.011986203,-0.047366224,0.07832249,-0.03455213,0.045306996,-0.05431884,0.0027994383,0.18986928,-0.05079944,0.046744354,-0.0605384,0.014668235,-0.056097116,0.016207187,-0.019352905,-5.4855672e-08,-0.017227558,0.03283387,-0.018506447,-0.044460453,-0.007963969,0.0103061525,-0.04491654,0.060910974,0.029316008,-0.025697742,-0.029818341,0.01565757,-0.0023552163,-0.04788616,-0.006943327,0.029367406,-0.018380348,0.057861138,-0.046866883,-0.010185488,-0.12670341,-0.019053709,-0.093092225,0.014160438,-0.056579877,-0.07472764,0.09725765,0.05113897,0.02367269,-0.11593003,0.004385673,-0.03899156,0.0119012045,-0.063044846,-0.070383094,0.033484127,-0.010976307,0.016600432,0.102940254,0.05032664,-0.012298921,0.016293865,-0.03335934,0.023401741,-0.055499356,0.0062905415,0.017638369,0.032199662,-0.045535963,0.07674634,0.020636126,0.010113313,0.015437742,-0.06133313,-0.025186757,0.0077621336,-0.013693723,-0.050810535,0.067589045,-0.020393563,0.003050301,-0.012530719,0.107676215,0.019732894 +2.4.1.224,"Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the enzyme from human (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the 4-beta-glucuronosyltransferase (EC 2.4.1.225, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase) activity required for the synthesis of the heparan sulfate disaccharide repeats. Other human forms of this enzyme (e.g. the product of the EXTL1 gene) have only the 4-alpha-N-acetylglucosaminyltransferase activity. In Caenorhabditis elegans, the product of the rib-2 gene displays the activities of this enzyme as well as EC 2.4.1.223, glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase.",384,1.0,-0.089702696,-0.056924574,-0.07710103,-0.03724463,-0.0053654993,0.0012701629,-0.05922157,0.08262044,0.058917765,-0.035976827,0.047857754,-0.0005368916,-0.043393753,0.03162543,-0.09403513,-0.016896518,-0.07937911,0.019411488,-0.0061173104,-0.105436355,0.05200086,0.047725294,0.014313932,-0.012214501,0.019132523,-0.064297244,0.005960111,-0.060696907,-0.02106658,-0.06140055,0.030626906,-0.13669579,0.020096697,-0.011046806,0.04105529,0.09971208,0.012931358,-0.024864478,0.012672282,-0.038962055,0.029346673,-0.011354977,-0.03349157,-0.040424537,-0.01064996,-0.05209497,-0.040367138,0.02833545,0.03219978,0.024256598,0.02961119,-0.025548525,-0.025966806,0.020600438,0.111844495,-0.011176747,-0.08442305,-0.029846063,0.036204055,-0.0073564444,-0.023070365,-0.0089864135,-0.017226823,-0.04953953,-0.0069470303,0.0018389183,0.108408056,-0.037202124,-0.009620698,0.014513215,-0.027129022,0.06398535,-0.029870806,0.07285105,0.035251312,0.045880098,-0.02722548,0.015522955,-0.0015332169,-0.024659244,0.05456219,0.030416166,0.07411812,0.034246083,-0.008643609,0.015038192,-0.03271706,0.046966176,0.04119758,0.04965661,0.0006495464,-0.046071224,0.014551697,-0.015323714,-0.0044227825,0.061545923,0.008405915,0.065588176,0.005602321,-0.038272772,-0.027741728,0.02214638,0.016127206,-0.0850457,-0.02037483,0.021422474,0.032637436,0.11022115,0.019537618,0.025175344,-0.024052482,-0.059816778,0.0047797696,-0.014712307,-0.09337047,0.0727701,-0.029902576,-0.032627676,-0.03176576,-0.011751448,-0.011039364,0.10052725,0.05582161,0.09606125,0.010694803,0.010872788,-0.057030924,5.5571635e-33,0.06881448,0.025244784,0.075154886,0.04316208,-0.004700233,0.06320248,-0.102490515,0.032171134,0.010074238,-0.07491351,-0.09828295,-0.06950189,-0.011140657,0.008803062,-0.0036382335,0.04744944,-0.029757526,-0.057352915,0.0148105975,0.035085727,0.0007635786,0.025096348,-0.035801545,-0.016510863,0.045360338,-0.021661986,-0.06501093,0.031632084,0.023771513,-0.007331777,-0.019379182,-0.03473829,-0.029146804,0.02627975,0.021737326,0.005813699,-0.0046080346,-0.059071105,0.06737919,0.084966555,0.048397385,0.058559224,0.0033084222,-0.08735461,0.0016276932,-0.060426567,0.059488196,0.0828463,0.010865796,0.064979866,0.08488074,0.027871132,0.12316747,-0.04684201,-0.05613904,0.022773512,-0.006390781,-0.10305871,0.023592208,0.10911517,0.004086216,0.058217954,0.026828932,-0.014826977,-0.028224494,-0.044875592,-0.06866236,-0.0031780154,-0.067878686,0.03659061,-0.03825989,-0.077933244,0.08425467,-0.025661843,0.039542288,-0.09933525,-0.01224893,0.05467281,-0.07534904,0.017498704,-0.07175054,-0.0032900218,-0.020632004,-0.018970843,-0.05814472,0.089981414,0.029731952,-0.07857582,0.008334792,0.06791654,-0.05458904,-0.05928007,-0.113564216,0.045681,0.03936201,-7.463734e-33,0.024402404,-0.041218873,0.032622974,-0.048276655,-0.084703684,0.100467265,0.012791433,0.0029954575,0.07206468,0.010307166,0.038023725,0.038069118,0.09569894,-0.09106581,0.008088146,-0.015243775,-0.04803539,0.0997412,0.025893519,-0.024057616,0.018403232,0.10674108,-0.035863522,-0.0049850517,0.07342322,-0.027066596,0.005552865,0.07486711,0.022462321,0.03300612,-0.040895764,0.002996906,-0.04116857,-0.022717547,-0.03475249,-0.03199026,-0.02028646,-0.026112175,0.0071341754,-0.019156558,0.018006196,0.07316358,-0.0071943146,0.07471342,0.029567987,0.1535059,0.035571475,0.045818683,-0.027238164,-0.01664432,0.0005053941,-0.0059816656,-0.07367449,0.09800551,0.013693249,0.02595606,0.028127763,0.06823794,-0.028237637,-0.025564298,-0.075361304,-0.058625527,0.017049016,-0.031433284,0.031920806,-0.011425311,-0.020540299,-0.016557643,0.044217274,-0.011552379,-0.008196839,-0.09056388,-0.012177399,-0.015437039,0.004999849,0.0049130283,-0.092160754,-0.084996656,-0.04885859,-0.077237666,-0.014400994,-0.017940216,0.035920132,-0.06706119,0.026209041,-0.047997214,0.031212965,0.18727066,-0.011889341,0.09914782,-0.045654308,0.021768214,-0.040562194,0.04589853,-0.021549378,-5.3938287e-08,0.016663572,0.05056228,-0.0039126533,-0.03257869,-0.06439886,-0.018355545,0.021695413,0.06856284,-0.012736261,0.00040946706,0.0045762407,0.030358382,-0.048289478,-0.058322635,0.013507076,0.06904367,-0.044678763,0.031735048,-0.038166832,0.037652656,-0.11364611,-0.022872401,-0.062628455,0.08991023,-0.06764695,-0.05148751,0.06426912,0.012233113,-0.003948354,-0.09377481,0.020112323,-0.014622315,-0.016098352,-0.11486184,-0.11124433,-0.00068586296,-0.021882918,0.024630519,0.1128494,0.07763486,-0.027537227,-0.02575163,-0.0075294725,0.03889939,-0.045841366,0.016489197,0.008904537,-0.0054394817,-0.034106895,0.060826533,-0.017279984,-0.02169852,-0.012754241,-0.10529566,-0.04614783,-0.01879435,-0.030864984,-0.04173248,0.06438863,-0.022928549,0.020080661,-0.004561445,0.10541459,0.014573349 +2.4.1.225,"Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.224) activity required for the synthesis of the heparan sulfate disaccharide repeats.",384,1.0,-0.085168116,-0.052348707,-0.12543945,-0.033742346,-0.044121426,0.04542191,-0.06551071,0.07012728,0.03586259,-0.0333862,0.025290245,0.060074653,-0.021593137,-0.012157807,-0.103998154,-0.055958252,-0.068082966,-0.010402389,0.002419044,-0.13321386,0.058263004,0.0008211577,-0.041514162,-0.038892142,0.04908215,-0.049041126,0.030872742,-0.037584405,0.02165508,-0.035055242,0.01728499,-0.12305988,-0.006996476,-0.019401625,0.0699004,0.10093389,0.017550658,-0.0021372242,0.0063178437,-0.08676476,0.053746592,-0.020751115,-0.02490621,-0.036143415,-0.027002936,-0.07741651,-0.031982284,0.04355413,0.04448042,0.0041795345,0.0023875504,-0.022827482,-0.025423976,-0.009901671,0.10368338,-0.047048256,-0.09631845,-0.008820613,0.06667565,-0.010442191,-0.029649498,0.0099367695,-0.018252654,-0.027983159,-0.00037265383,-0.05336089,0.106064536,-0.015410554,-0.013953457,0.045129713,-0.029615367,0.06623678,-0.012159636,0.10558013,0.03874984,0.022285016,-0.07942769,0.015370825,0.0009216547,-0.0008886513,0.054555643,0.026047945,0.07485313,0.084181875,-0.035834584,-0.022461738,-0.01871729,0.015496366,0.07033871,0.03329363,-0.034544833,-0.053907365,0.016973624,-0.04682245,-0.0192648,0.041288137,0.009333355,0.073454596,0.0124281375,-0.042113703,-0.0011244995,0.024835479,0.022257643,-0.052081082,-0.034846693,0.04669854,-0.040536467,0.14137903,0.07353872,0.042119704,-0.009844703,0.010000791,-0.023360372,-0.045567457,-0.12223982,0.043181736,-0.019240126,-0.07738715,-0.09356874,-0.011726806,-0.025662858,0.049120083,0.051898975,0.101832345,0.014378437,-0.029938806,-0.009953262,2.7501789e-33,0.0939524,0.017680388,0.09950567,0.0013332294,-0.031493843,0.009658294,-0.09004985,0.019540211,0.02569131,-0.040027697,-0.07824789,-0.09170073,-0.010101213,0.06100315,-0.030961396,0.048519526,0.008595468,-0.06416854,-0.011765619,0.030147104,-0.026723228,0.02250658,-0.039310873,-0.0047721826,0.026739903,0.021559771,-0.062584005,0.04878665,0.03104209,0.004122137,0.02688343,-0.033948585,-0.031388823,0.021937015,0.057303526,0.006892232,0.0027778598,-0.051195834,0.06824787,0.068145655,0.06887014,0.044492647,0.036037784,-0.08194188,0.034226242,-0.061199605,0.05969536,0.046984766,0.0032415327,0.079244256,0.026521852,0.03327048,0.10348234,-0.018418621,-0.07175238,0.037927035,0.021528838,-0.0886848,0.01971099,0.095483206,0.03397089,0.021419037,-0.008267205,-0.019964006,-0.002061095,-0.024418859,-0.041423555,0.0017124256,-0.03740309,0.051499914,-0.065263376,-0.09561318,0.01604853,0.017691353,0.038959004,-0.06957559,0.0069171977,0.09177553,-0.011248956,-0.03925797,-0.01617945,0.023757022,-0.03591541,-0.01763304,-0.050927978,0.07609454,-0.015339999,-0.11996434,-0.044412103,0.037800513,-0.06705217,-0.022338374,-0.07217753,0.043659694,-0.014603907,-7.442446e-33,0.044120453,-0.038144823,0.03778527,-0.017373916,-0.05169366,0.04248755,-0.010460601,0.06288494,0.044428464,0.012970489,0.031968046,-0.01887891,0.07474703,-0.05299295,-0.026788626,0.02410744,-0.011676979,0.09629701,-0.010804443,-0.008246593,-0.023190256,0.09338916,0.01752208,-0.020380856,0.049581856,-0.029987616,-0.0077313203,0.033373717,0.0362723,0.113838166,-0.037361585,-0.02644965,-0.057452895,-0.08862856,-0.037335195,-0.04770224,-0.040603984,-0.013423586,0.0053145424,-0.015167385,0.023226343,0.07155448,0.06001165,0.04819687,0.05852316,0.11370633,-0.023720091,0.087983005,-0.05867757,-0.041575093,0.005126323,0.031102428,-0.042386226,0.11861696,0.02213986,0.028389493,0.072310165,0.04220734,0.008204406,-0.014402692,-0.066417545,-0.037576936,0.010103153,-0.05996241,0.0055341315,0.021927312,-0.039311595,-0.03351783,0.0017178751,0.006042032,-0.0268462,-0.122121476,-0.002880883,0.0018311116,0.008410041,-0.029298645,-0.11949158,-0.0488931,-0.05165302,-0.015356294,-0.0052001183,0.0041101873,0.023006523,-0.10068233,0.024370719,-0.0015757096,0.0017621261,0.13792662,0.019473825,0.105780125,-0.023710627,0.038823348,-0.037935007,0.01498298,-0.07241612,-4.8342727e-08,0.005114919,0.021719847,0.017586,-0.041040417,-0.057702664,-0.008247634,-0.01758861,0.007464923,-0.004633549,0.003009325,0.010066303,0.025961766,-0.04672333,-0.06327062,-0.052851137,0.05643452,-0.03724967,0.030256346,-0.040051024,0.04448248,-0.12092579,-0.028028216,-0.046418864,0.09239218,0.025349392,-0.059757162,0.040662874,0.019535517,-0.02930937,-0.044884887,-0.010970394,0.04686195,-0.03133558,-0.090038285,-0.123455495,0.011402064,-0.01171425,0.02001843,0.09002923,0.0032081844,-0.014523375,-0.022560267,0.013411492,0.04325269,-0.0036990382,0.051387407,0.043775845,0.02894529,-0.07387948,0.03416765,-0.061865315,-0.050576817,-0.042314574,-0.11301616,-0.019012691,-0.0660406,-0.018551156,-0.060249936,0.08242234,-0.043052018,0.013844846,-0.011806021,0.08466656,0.004263056 +2.4.1.226,"Involved in the biosynthesis of chondroitin and dermatan sulfate. The human chondroitin synthetase is a bifunctional glycosyltransferase, which has the 3-beta-glucuronosyltransferase and 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175) activities required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli. There is also another human protein with apparently only the 3-beta-glucuronosyltransferase activity.",384,1.0,-0.11183568,-0.15109518,-0.09587085,0.014542467,-0.07413025,0.023334887,-0.049457435,0.04848586,0.036803376,-0.02808133,0.03058157,0.046858914,-0.05402062,0.05642309,-0.11981885,0.002466939,-0.08957108,0.027390508,0.09758519,-0.047507934,0.043005552,-0.0015357397,0.0106600365,0.0049399002,0.010044552,-0.054879677,0.034880526,-0.072308265,-0.02116802,-0.0040756394,-0.082211465,-0.061827958,0.025100475,-0.021731265,0.07209337,0.05084636,-0.0031852562,-0.05143101,0.0597679,-0.023910228,0.069826275,-0.026031908,0.021380588,-0.02484498,0.01751023,-0.11128124,-0.039996494,-0.046608187,0.06626007,0.06315134,0.0070631867,-0.0006419036,0.010472482,-0.022114046,0.096863054,-0.058139313,-0.05565853,-0.04858476,0.10467709,0.037828576,0.022453131,0.032859985,0.0019407998,-0.067348875,0.038974654,-0.04094652,0.092372954,-0.008237385,-0.014036097,-0.013742218,-0.06887039,0.018379059,-0.022805518,0.06964332,0.0003070065,0.052878223,-0.054132063,0.01045744,-0.034995306,-0.051892538,0.043413684,0.00971646,0.030802384,0.081815034,0.010281056,-0.021936899,0.016568191,0.06955305,0.005469673,0.0065334253,-0.061102796,-0.020345004,0.014948843,-0.06746332,-0.010073567,0.028204542,-0.0019363076,0.0760364,0.007636275,-0.025529945,-0.030426653,-0.013863938,0.057300806,-0.053366754,-0.011925685,-0.0041911737,-0.009711124,0.08760566,0.06088839,0.020399265,-0.019580707,0.04901301,0.0011253579,0.0075520067,-0.06333126,0.07139203,0.005129551,-0.055668592,-0.05770335,0.09585955,0.024234863,0.016126418,0.014684619,0.059015274,0.00093128014,0.0009240548,-0.02916306,4.6177246e-33,0.10736053,0.08075326,0.08318667,0.024706094,-0.026507992,0.008034103,-0.082662374,0.005074612,-0.0011925987,-0.045241755,-0.0019691722,-0.01362729,0.023996884,0.061997082,-0.04728834,0.07835849,0.05889075,-0.044758845,0.06500012,0.01632494,0.015563245,0.035931256,-0.033524323,-0.011593229,0.04193089,-0.023369664,-0.065228224,0.049338177,0.06664664,-0.02149665,0.019865084,-0.067548975,0.032958403,0.0003016049,0.07199195,-0.023583727,0.02458997,-0.089026295,0.018183742,0.056052387,0.0929207,-0.0545825,-0.022066098,-0.079835735,0.06230795,-0.04612707,0.032228403,-0.029201409,-0.048053943,0.055213068,0.007947565,0.05870621,0.05085573,-0.028458083,-0.07481034,-0.018687628,-0.012256302,-0.10209655,0.042604342,0.08579286,0.030114377,0.037315942,-0.04781321,-0.07932139,-0.022270454,-0.04267004,-0.062085427,-0.011045813,-0.05006345,0.056267854,-0.049587615,-0.118333854,-0.015848514,0.0536331,0.04318872,-0.04396789,-0.056762226,0.08359009,0.0063357432,-0.07570709,-0.04462371,0.05641861,-0.0068769143,-0.04041435,-0.020479515,0.050740715,-0.041441336,-0.050382,-0.0065053897,0.021197012,-0.053239383,-0.048980348,-0.08438846,0.06874889,-0.06452994,-6.115534e-33,0.008783706,-0.063981555,0.006639194,-0.089583464,-0.04475548,0.015062456,0.02532076,0.026582943,0.03794575,-0.0067302124,0.07210157,-0.0330044,0.07460363,-0.10973192,-0.014165121,0.06365669,-0.015972385,0.021335753,-0.006733989,-0.045165565,0.02530621,0.090516955,0.06610885,0.06621503,0.032172803,0.034245983,0.028374523,0.02553478,0.021099553,0.13080277,-0.06417594,-0.04981223,-0.044489663,-0.10691523,-0.064845204,-0.04189503,-0.03193121,-0.0028027876,0.0109017,-0.008948783,0.0025466697,0.045470208,0.07868463,0.06562767,0.08153256,0.11054182,0.0008377771,0.0289761,-0.0002682866,-0.008955666,0.06899531,0.0015100288,-0.030981908,0.0020409022,0.038356144,0.06173417,0.045531854,0.0338349,0.06782906,-0.0070065637,-0.07876128,-0.0025983455,0.026717069,-0.0069235163,0.035261277,0.09909179,-0.035216648,0.015866106,-0.0053854017,-0.032628354,-0.0063887173,0.003311026,-0.0040213815,-0.0055613574,0.015557319,-0.005093779,-0.114655,-0.05450307,0.002138011,-0.028573891,-0.05206973,-0.03831782,0.0014964306,-0.06407708,0.0031565921,-0.021541523,0.015352839,0.107089356,0.048861183,0.066988386,-0.025063185,-0.020993361,-0.08863843,-0.009052126,-0.035998292,-4.1704578e-08,0.040205367,0.008820333,0.006022331,-0.024672592,-0.051816106,-0.042299636,0.006960016,0.0254885,0.033919387,0.003940441,-0.048746746,0.046304002,-0.011642556,0.011459965,-0.008764408,0.07615028,0.0234898,0.04115291,-0.035780534,0.012512816,-0.030917129,0.024893146,-0.024816101,0.12908234,0.0035246445,-0.08020396,0.0065210266,0.014702504,-0.06581496,-0.07255363,0.035989393,0.0101687135,-0.08787011,-0.06765881,-0.05830013,-0.027946904,-0.00046645897,-0.050388023,0.06219598,0.04925439,-0.02519106,0.013469407,-0.04601993,0.04794047,0.00600242,-0.002142783,0.00097185967,0.036571104,-0.036043458,-0.007311152,0.033134244,-0.102088265,-0.052113343,-0.091560096,-0.035770815,-0.0509985,0.05075545,-0.0658619,0.044198014,-0.020206105,-0.03884873,-0.058864046,0.19721699,0.001100458 +2.4.1.227,"The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, {iupac/misc/prenol#p6::click here}).",384,1.0,-0.04181435,-0.1016599,-0.033402488,0.0017629561,0.0754185,-0.068401836,-0.049269028,0.04061615,0.058289852,-0.0008331786,0.044012323,0.00024778795,-0.029396314,0.0698183,-0.05216544,0.082360744,0.002618141,0.024041675,-0.012856697,-0.01976518,0.10243413,0.0021757262,-0.04058565,-0.021210933,0.06636662,-0.045124937,0.050433204,0.041311946,0.08852432,-0.0710805,-0.033259824,-0.037338383,0.041078072,-0.049821056,0.02407797,0.08998462,-0.06597357,-0.049978532,0.027246166,0.042055666,0.010500675,-0.022166574,-0.045171194,0.013242216,-0.011798412,-0.04131151,-0.0971797,0.12361428,0.052664332,0.013483715,0.007989483,-0.03597364,-0.024928413,0.072905675,-0.053149562,-0.008895387,-0.14398843,0.031813614,-0.023476463,0.00096378353,0.044791013,0.099300176,0.024384765,-0.024388816,0.042936243,-0.017264994,0.0025493815,-0.03631992,0.05329756,-0.006597132,-0.046244334,-0.07936093,0.05570707,0.043537244,0.06991464,0.02789553,-0.028189508,0.0015763674,0.007726737,-0.019604912,0.057790004,-0.0072482703,-0.027203765,0.069472946,0.047532655,0.045527868,-0.05054986,0.03835366,0.02406949,-0.014465007,0.020502914,-0.048064765,-0.08116763,-0.08165382,-0.011465116,-0.045656495,0.0008064086,0.08074675,-0.03676853,-0.009916874,0.016058652,0.03814276,-0.14118905,-0.0765709,-0.11064243,-0.0057755276,-0.0096183345,0.004205971,0.05667476,-0.012305515,0.018987378,0.03391844,0.06240076,0.043944612,-0.023324711,0.100724354,0.018774327,-0.053289875,-0.019207645,-0.002372413,-0.040869154,-0.021172797,0.024009,0.048960622,-0.0836998,0.07176097,-0.02535677,2.9459655e-33,-0.056645717,0.043930333,-0.0011687592,-0.026376685,-0.012709772,-0.0065754107,-0.07901143,0.010223332,-0.046717245,0.019391201,-0.06093219,-0.023479588,0.035488036,-0.044135474,0.016616477,0.0018792832,0.07512815,-0.024167929,0.052156642,0.03742257,0.067167275,0.051670443,-0.02293226,-0.020436315,0.042240832,0.10387186,-0.013476109,0.027372103,0.07155834,0.025133448,-0.01599698,-0.09421673,-0.05321695,0.007804202,-0.051804945,-0.058816172,-0.068649426,-0.031697985,-0.011998407,0.013796018,-0.0180159,0.071891285,-0.022272568,-0.039170463,0.058256343,-0.11453219,0.014977189,0.1270505,0.10104405,0.028026124,0.09391683,-0.0334292,0.033621397,-0.10562931,-0.10010799,-0.008775005,-0.03170213,-0.004642409,0.0660357,0.05557248,0.04781765,0.025565077,-0.058283236,0.007771535,0.01837715,0.042271852,-0.064995505,-0.016857455,0.026581442,0.045504127,-0.08085966,-0.033424113,0.0039719627,0.059197016,0.0025420217,-0.03927715,-0.030209024,0.03970617,0.104721904,-0.046463735,0.06529122,-0.037859127,0.05167088,-0.01929632,0.0017125591,0.028214244,-0.013405374,-0.06539453,-0.013072155,0.050382607,0.12292919,-0.064606324,-0.056403108,-0.00815792,0.023374448,-4.7901582e-33,0.093264155,-0.09490333,-0.014872126,-0.033835355,-0.034655843,0.041799072,0.016384102,0.0046617985,0.06749283,-0.021310117,0.072242014,-0.014894312,0.0028550625,0.040076952,0.043577414,0.05018242,-0.052576624,0.011321586,-0.0066338456,0.026617361,0.012967653,0.027132979,0.03781996,-0.011961537,0.0351378,0.016812464,0.003809208,0.024407458,-0.0034948804,0.056057557,-0.014233361,-0.0015928576,-0.077156484,-0.119159564,-0.028671794,-0.025153454,-0.11106707,-0.050701294,-0.019575568,-0.00211783,-0.022626357,0.042460173,-0.040883288,0.038060766,-0.059534907,0.054628517,-0.09364992,0.009524222,0.053154174,-0.076527536,0.014673884,-0.039955165,-0.0073554604,0.03532709,0.0004176688,0.04126486,0.012481321,0.029149316,-0.04552209,0.0116597125,-0.0583646,-0.07085073,-0.05105801,-0.019530814,0.08038284,0.055641524,-0.014756592,0.08167383,0.025690794,-0.06170601,0.073728725,0.01669577,-0.023850076,-0.04633666,-0.041499753,0.024415148,-0.038606074,-0.042876642,0.06880535,-0.06581081,-0.056447648,-0.0119899865,-0.060797088,-0.059674054,-0.01693644,-0.0716582,0.008594253,0.15276675,-0.021016877,0.055283677,0.042352322,-0.0034576913,-0.041497193,-0.035034187,0.15200011,-4.7864745e-08,-0.00031507292,-0.07579677,0.016049996,-0.024336422,-0.0077079576,-0.040619593,-0.018735321,0.010244629,-0.000836721,0.031132491,-0.014468763,0.014478186,0.001872606,-0.060390152,0.021565126,0.0387751,0.03223777,0.09650781,-0.038398016,0.002173353,-0.058201198,-0.009799663,-0.04288617,-0.030957708,0.093475886,-0.10538646,0.010658094,0.056139063,-0.059455004,0.024972484,-0.03233504,-0.00706784,-0.028352458,-0.0509009,-0.07451506,0.062166337,-0.02614046,-0.005329305,-0.03631444,-0.025102738,0.026806233,0.0072308467,-0.0817425,0.0028955298,-0.007887762,0.010026718,0.043234017,-0.016987247,-0.029457148,0.020082092,0.010666112,-0.052257936,0.0061970893,-0.033782583,0.006474914,-0.04078191,-0.03880147,-0.016454777,0.0026626466,-0.04996071,0.04505261,0.082538284,0.17996003,-0.079202645 +2.4.1.228,"For explanation of superscript II in systematic name, see {iupac/2carb/37#372::2-carb.37}.",384,1.0,-0.13784638,0.015115958,-0.018077064,0.03229124,-0.0487004,-0.042880766,-0.05260394,0.11856452,-0.022081692,-0.045413617,0.06685844,0.017015176,-0.048307616,-0.005557634,-0.07733344,0.03760963,0.015785838,-0.03793696,-0.0022013853,-0.03492113,0.07966109,0.026140766,-0.014870593,-0.010606955,0.031936504,0.03414268,-0.060751047,0.01910264,0.07566703,0.008261754,0.0618771,0.07340488,0.005898005,-0.016915282,0.031637896,-0.020228112,-0.028461197,0.0019226478,0.06245707,-0.08124478,0.057145905,-0.0049614343,0.029059239,0.059676558,0.067851566,-0.0036585592,-0.07299625,0.045528084,-0.025384964,0.0039461744,-0.055199515,-0.043707702,-0.053893078,0.04564372,0.038480278,0.05911072,-0.12859075,-0.025834545,0.012997996,0.048123848,0.038546305,0.04780099,0.032655045,-0.008969453,0.10385152,0.06887085,-0.029319448,-0.030157294,-0.025299257,0.09054511,-0.022784688,-0.022685055,0.021139378,0.06612932,0.062780336,-0.041906644,-0.018685672,-0.034377314,0.050939776,-0.04741193,-0.05939855,-0.0704773,0.016584627,0.0053880927,-0.023926146,0.013268381,0.066045955,-0.07753007,0.021992356,0.02318169,-0.0021299573,-0.114872776,0.04250862,0.02184291,-0.053670608,0.030762425,0.073839195,0.10095005,0.034303952,-0.018094108,0.028783504,-0.037068665,-0.00903634,-0.09740629,-0.098913565,-0.011155941,-0.043434646,-0.02701784,0.055325605,0.007985284,-0.04397174,0.047942635,-0.026635999,-0.08043883,-0.11555926,0.03494205,0.035060894,0.011198373,0.09119818,-0.038823236,0.03235896,0.043490432,-0.028122671,0.053671453,-0.030042449,0.008887002,-0.07908074,7.4525166e-34,-0.01719931,3.7510905e-05,0.037661675,0.009816916,-0.039530016,-0.064141005,-0.046957724,-0.063655175,-0.11025953,0.07631279,0.019653851,0.019459737,0.011826732,0.004295574,-0.059118383,-0.049895246,-0.025790513,-0.0051498874,0.05219679,-0.05377218,0.0013829877,0.1412545,0.00055674335,0.0041198474,0.013614176,0.017560333,0.07061025,-0.024326246,0.034388106,0.05925413,0.060921203,-0.02176393,-0.08658134,0.016929481,0.041169323,-0.057773177,7.709598e-05,-0.07097013,-0.016161991,0.019276801,0.06409432,0.032334007,-0.03660651,-0.012975424,-0.0068657165,-0.08810895,0.039323844,0.058219854,0.075958125,-0.033336382,-0.04347766,-0.00873174,0.020341294,0.07808134,0.02901348,0.09609223,0.005464111,0.100928724,0.0001547117,0.0058224536,0.0014422393,0.07122915,-0.010624541,0.12675619,-0.090857774,-0.038534414,-0.102407046,0.01070883,0.0038687182,0.08338843,-0.014305719,0.034068782,0.08662792,0.020867923,0.08434451,-0.039423913,-0.03855988,-0.012766251,-0.041511294,0.029559929,-0.09309052,0.037659213,0.0046084453,-0.011705649,-0.042385634,-0.010707656,-0.077719785,-0.09687195,-0.044523846,0.01494465,-0.00035308782,-0.024114775,-0.030097604,-0.043010198,0.0010672259,-3.149598e-33,-0.016351648,-0.043921106,0.05147472,0.01693205,-0.025491687,-0.07271689,0.023809386,-0.090824045,0.07248287,-0.031711563,0.122765,0.11831091,0.009644808,-0.07337319,0.12396716,-0.014878581,0.0064742994,-0.036651414,0.0020296627,-0.07443432,0.036143217,-0.004618174,0.008828546,0.021724103,0.0055678706,0.007896772,-0.012850078,0.11989704,0.03531147,0.0247036,-0.030015573,0.016507389,-0.04800518,0.037858125,-0.070667915,-0.028789438,-0.008720866,-0.035609104,-0.06747227,-0.05880452,-0.077627264,0.019895619,0.0007045424,0.07951381,-0.002371652,0.04113939,0.033819996,-0.000434674,0.085253365,-0.091637954,0.014831995,-0.08688366,-0.059817545,0.035888948,-0.011670643,-0.025552781,-0.03504203,0.0064710937,-0.041098386,0.05460789,0.11311806,-0.029502587,0.0086365575,-0.00052109396,0.040590458,-0.08389804,-0.100434,-0.07950236,0.028858237,-0.054014325,0.10153794,0.00023846804,-0.056260854,0.025283888,-0.039959036,-0.02003555,0.049321704,-0.011051463,-0.025197959,-0.042685647,-0.043611817,0.040252242,0.016092854,0.06493364,0.01026437,-0.035430633,-0.070523344,0.14755423,0.013875888,0.008935444,-0.04534881,0.073154874,-0.07133562,0.020971816,-0.0023096409,-2.9991956e-08,-0.04542049,-0.049814638,-0.0036695865,-0.10188479,0.018243555,-0.024843354,-0.06619331,0.0031065692,0.00018995428,-0.051591437,0.016729848,0.049608197,0.01772676,-0.017173493,0.01817612,-0.034135003,-0.01586766,0.030682568,-0.045325525,-0.005431328,-0.049400356,-0.029518524,0.015525417,-0.048246294,-0.086418204,-0.04024826,0.02719171,0.032344718,0.001484691,-0.01923355,0.012293244,0.060214534,0.06908325,-0.02784944,-0.008262067,0.046436295,0.007245486,0.03607409,0.016618807,0.023835555,0.04290699,-0.07123512,-0.04514988,0.07693373,0.020921262,0.033666052,-0.014682909,0.085936725,-0.030651622,-0.061209664,-0.0012586033,0.012244621,-0.091955245,0.04389336,-0.021582678,0.017631358,-0.054650012,-0.0026272766,0.042026773,-0.058544125,0.044217892,0.0354473,0.02513027,0.01602828 +2.4.1.229,"Skp1 is a cytoplasmic and nuclear protein required for the ubiquitination of cell cycle regulatory proteins and transcriptional factors. In Dictyostelium Skp1 is modified by the linear pentasaccharide Galalpha1-6Galalpha1-L-Fucalpha1-2Galbeta1-3GlcNAc, which is attached to a hydroxyproline residue at position 143. This enzyme catalyses the first step in the building up of the pentasaccharide by attaching an N-acetylglucosaminyl group to the hydroxyproline residue. It requires dithiothreitol and a divalent cation for activity.",384,1.0,-0.067592815,-0.07525199,-0.046153672,-0.029980673,0.037808456,-0.018188963,0.015399585,-0.012879822,-0.009650764,-0.04206984,0.075434156,0.036398243,-0.047417603,0.033587232,-0.068076715,0.013024197,-0.09909745,-0.012876374,0.050330564,0.054456502,0.10587,-0.032014083,-0.045038693,-0.004728709,0.122715235,-0.06105534,0.0030448032,0.017418671,-0.0039237207,-0.1120787,-0.016305069,0.0271633,0.014276356,-0.114914976,0.054675817,0.023678925,-0.012015231,-0.03507416,-0.009703139,-0.07328082,0.117428176,-0.014739847,-0.0018574004,0.00845991,0.0018539141,0.033559147,-0.02988081,0.0788695,0.015097384,0.061949477,-0.058976375,-0.039617967,0.04774406,0.04538076,0.012483599,0.05288208,-0.03826355,0.055272784,0.06704732,-0.040085323,-0.0053829406,-0.005544425,-0.006006951,-0.02941976,0.013487794,-0.06334874,-0.006820029,-0.0998016,-0.033178046,0.05256015,-0.025134586,-0.05395749,-0.018465612,0.056629647,0.023171024,0.09616545,-0.047512032,0.038391326,0.038645994,-0.0013681939,0.035163466,0.06252847,0.044682633,0.12421495,0.053851303,-0.01440016,0.039302092,-0.034001365,0.009919643,-0.032060325,-0.011193021,0.021386784,0.032314993,0.01535809,-0.08845253,0.121439464,-0.032429628,0.029040348,-0.023932496,-0.012003222,0.0433421,-0.02282666,0.029002875,-0.056228355,-0.06933783,0.03466144,-0.05879102,-0.0075817057,-0.03734824,0.057712227,0.021356244,-0.01983915,0.021858925,-0.04383988,0.017460786,-0.010998574,-0.016729327,-0.047900178,0.062564835,-0.068058096,-0.010074865,-0.046608403,0.022206469,0.08083075,-0.03712971,0.029693643,-0.078420885,6.0222747e-33,0.033538193,-0.030825436,0.0001624189,-0.005844614,0.005388532,-0.083343126,-0.053277683,-0.0729257,-0.117922604,-0.05078667,-0.032202996,-0.03837054,0.017529996,0.00020085425,-0.08697154,0.015103014,0.016852014,-0.03963177,0.091411464,0.008656203,-0.048149846,0.002760761,-0.052526318,-0.06849055,0.052187797,-0.025503555,-0.056335557,-0.011083622,0.028163847,-0.010553405,0.037317727,-0.006773697,-0.10450297,0.043603275,-0.049202256,-0.005037651,0.04515988,-0.11147731,-0.023503868,0.06721351,0.012136031,0.0657533,-0.013817771,-0.09595235,0.07461376,0.04922264,-0.011160018,0.12331928,-0.013378003,0.045506306,0.07177221,-0.0129447365,0.04719402,0.016850568,-0.07060793,0.04672706,-0.043331545,-0.05238141,0.03695482,0.059586048,-0.049650703,0.039670106,0.012647777,0.048315145,0.028789718,0.03238397,-0.095191464,-0.034152523,0.005063095,-0.0060545853,-0.11575427,-0.05498136,0.04097945,0.010102079,-0.030578727,-0.051063843,0.010737298,0.025050435,-0.0047135074,0.10480473,0.022180079,-0.042465534,-0.05260871,-0.031834573,-0.049371295,-0.042473294,-0.0015491113,-0.031587347,-0.035288274,-0.022285033,0.07086712,-0.06055513,0.0033146217,0.10077995,-0.00508739,-6.453198e-33,0.06910466,-0.096533716,0.11990765,0.000997289,-0.03170706,0.042468533,0.041326396,-0.0709307,0.07291161,0.05545225,0.061216805,-0.016232796,-0.018671766,-0.018961491,0.0132927485,-0.039168306,0.010468337,0.058488708,-0.007839827,0.017980319,-0.055374406,0.117192134,-0.05465271,0.09386183,-0.0491701,0.01470552,0.026939476,0.06432732,0.031174315,0.03133597,-0.06259049,0.07031467,-0.09022786,-0.035805598,-0.0058819344,-0.019444475,-0.060593326,0.009742947,0.065955184,-0.00677506,-0.008372314,0.061222892,0.0017100738,0.0321352,0.06813101,0.028796172,-0.015518824,0.07173506,-0.030978367,-0.014612032,0.024467971,0.02105632,-0.030475402,0.07934454,-0.004107794,0.042559303,0.0873589,0.061190248,0.0022804881,-0.006174295,-0.022772996,0.00027748765,0.010204378,0.024558391,0.072770394,0.054548126,-0.039266426,0.036049068,-0.043272678,0.049336232,-0.063545614,0.08259683,0.02393884,-0.010357799,0.019789962,0.047573756,-0.0730006,-0.020887595,0.024324106,-0.017593749,0.019026244,-0.036504105,-0.07515551,-0.031854797,0.04383567,0.0024230673,-0.03451162,0.13704152,0.043877076,0.034412753,-0.017809218,-0.027802423,-0.070985876,0.06374095,0.035953965,-4.584291e-08,0.029117715,0.03294555,0.00046951426,-0.058643572,-0.020593803,-0.020523572,0.0211591,-0.0031823104,0.09937792,-0.018781768,-0.03007084,0.101700604,0.0010447688,-0.06248374,0.025111048,0.0788976,0.0012286358,-0.0003851173,-0.016134113,-0.005957821,0.029101297,-0.05678137,-0.1276193,0.04056692,-0.04124655,-0.109632604,0.07916155,0.118969895,0.048888113,-0.06044811,-0.012294336,-0.011359059,-0.030693028,-0.047521498,-0.015073603,-0.0036672342,-0.018672446,-0.061706364,0.06867707,0.04632767,0.0033648333,-0.009573057,-0.0010191862,-0.08373775,-0.12197626,0.025875645,-0.00847517,-0.048229624,-0.050754543,0.04517303,-0.035372578,-0.010348644,-0.060134258,-0.033646345,-0.06329719,0.022358872,0.016449604,0.025651157,-0.012038044,-0.021236,-0.09876518,0.020947145,0.118867606,-0.00706507 +2.4.1.230,"The enzyme from Thermoanaerobacter brockii can act with alpha-1,2-oligoglucans, such as selaginose, as substrate, but more slowly. The enzyme is inactive when dissaccharides with linkages other than alpha-1,2 linkages, such as sophorose, trehalose, neotrehalose, nigerose, laminaribiose, maltose, cellobiose, isomaltose, gentiobiose, sucrose and lactose, are used as substrates.",384,1.0,-0.014520724,-0.13672124,-0.14131036,0.015531445,0.008339044,0.062593885,-0.063063495,0.012012138,0.020215191,-0.042049937,0.013490933,-0.05550952,-0.049928315,0.056992196,-0.038527183,0.014009398,-0.02208295,-0.003850033,0.011889638,-0.02559419,0.095784485,-0.016084297,-0.026752504,-0.0053181024,0.04586662,-0.011975567,0.020697258,-0.032892317,-0.012657961,-0.061837606,0.04112625,-0.055607557,0.06884339,-0.01914449,0.042485435,0.10309201,-0.05785711,-0.06332277,0.07078132,0.025137253,0.06605049,0.019549754,0.014721256,0.026022445,-0.08043104,-0.03098735,0.009336901,0.028246613,0.022920312,-0.020102287,-0.03550948,-0.100798935,-0.046140224,0.009477284,0.027424922,0.025018321,-0.02040049,-0.10033291,-0.02048059,0.0255616,0.08475699,0.061379638,-0.00998113,0.015420827,-0.012775886,-0.034340397,0.02569309,-0.022035839,-0.030659912,0.03298808,-0.080719635,-0.0001252496,0.017024266,0.032863766,-0.008236475,0.0041528437,0.031529203,-0.035289057,0.036526803,0.0013240151,-0.05748283,-0.0984914,0.039385956,0.05795127,-0.044457346,-0.030487422,0.065215945,0.017012637,0.06621233,0.050192047,0.024747653,0.08103369,0.07155595,-0.08078981,0.01317297,-0.017983219,-0.026568823,0.037836242,0.046919797,-0.05162784,-0.07146658,-0.00401848,-0.0031408085,-0.047673676,-0.059851814,0.033535846,-0.053427845,0.028381016,0.06837873,0.04242439,0.024450878,-0.050240427,0.021560658,0.034393713,-0.040710226,0.047157507,0.03539849,-0.06035763,-0.04597009,0.038958378,-0.05169386,0.008385514,0.11254806,0.015630003,-0.11087621,0.07691908,-0.03485767,4.2534804e-33,0.07968434,-0.016574297,-0.045883995,-0.101770654,0.024040848,-0.018449299,-0.09252075,-0.011902958,-0.027770953,-0.0026528311,-0.07073024,0.008383278,0.029060049,0.039100166,0.05474899,0.047545977,0.040472973,0.004439977,0.0042845574,0.08266332,0.00065056613,0.0714712,0.043351546,-0.010566704,0.05765195,0.051898,-0.02899813,-0.036887154,0.034662914,-0.004650723,0.057787538,-0.099753425,-0.19120018,0.05795644,0.08188902,-0.024931472,-0.068684004,0.009947242,-0.025155239,0.016605433,0.036405705,0.018085202,0.09241268,-0.020154733,0.07117705,-0.040834565,0.0034939677,0.10509562,0.0069455206,0.08905052,0.012636594,-0.04648524,0.03294512,-0.040781997,-0.0022823599,-0.015833195,-0.019159527,0.07320487,0.0052401754,0.012858745,-0.012862392,0.009350073,0.017400159,-0.014051566,0.021413708,0.015021593,-0.027180042,-0.014326187,-0.034667782,-0.028376175,-0.060278885,-0.05784533,-0.03611054,-0.0030189182,0.021499714,-0.05756255,-0.0564906,-0.059305966,-0.009367474,-0.00083676336,-0.025848947,-0.06642752,0.017834257,-0.04273205,-0.060258105,0.003209904,-0.012027877,0.0023347356,-0.030352622,0.08491591,-0.007374294,-0.051448114,-0.10710343,0.08652319,0.06084912,-5.5850146e-33,0.102832064,-0.13730344,0.053018097,-0.06979493,-0.121592835,0.06449783,0.05566874,0.004996945,-0.030954659,0.009499876,0.09346984,0.046577837,-0.00184329,-0.029733125,-0.0073282225,-0.01752072,0.048815757,0.09378203,-0.029098937,-0.06355497,0.01091014,0.13663962,-0.008595276,-0.0038554848,0.047104813,-0.012281773,0.0755805,0.06595919,-0.025534078,0.05024201,0.024964716,0.04478826,0.021321967,-0.09203898,-0.04901328,0.06154853,-0.005847607,-0.038393192,0.041786876,-0.029870186,0.061471447,0.06015478,-0.02680885,0.085502826,-0.010970252,0.06257603,-0.097191446,0.011073441,-0.014088994,0.058215026,-0.014041143,-0.076867506,0.00045807927,-0.00060629216,-0.039586242,0.008477919,-0.0019080085,-0.00017754555,-0.06415319,-0.064728774,0.013778472,-0.048403833,0.05647736,-0.016641906,0.04703186,0.055320133,-0.057927933,0.0057014166,0.061309993,0.0066504483,0.040436793,0.01377745,-0.03364287,0.017666882,-0.013519517,0.021206407,-0.058249287,-0.06820259,0.035345737,-0.07334964,-0.03360361,0.0779901,0.022980867,-0.056007385,0.0815722,-0.08737007,0.04670105,0.09731977,-0.00024790832,0.0805577,0.04311051,-0.024611602,0.0057803607,0.058860604,0.028847974,-4.4560302e-08,0.030068431,-0.0054305317,0.06868374,-0.052635595,-0.014375424,0.05214169,-0.009911302,-0.031827994,0.061422568,-0.032417845,-0.037233736,0.13751918,-0.0074840453,0.04347872,0.05011817,7.1562135e-05,-0.031765077,-0.033477627,-0.021175362,-0.039185774,-0.08707182,-0.06440441,-0.086885005,0.048012808,-0.0057717836,-0.038415506,0.025665142,0.03630869,0.022481274,-0.028699556,-0.014092578,0.030890057,-0.013957746,-0.04750945,-0.050525777,0.020093769,-0.010608651,-0.061283696,-0.0029904358,-0.011053907,0.06990628,-0.023485359,-0.057724297,-0.011122236,-0.0064097997,-0.013836176,0.013002693,0.049802672,0.0036292372,0.04520263,0.018077087,-0.025548082,-0.05428804,-0.019858325,-0.102072716,-0.034326587,0.016179945,-0.09155289,-0.053515274,0.0062967576,0.016989686,-0.06414411,0.13560869,-0.08220238 +2.4.1.231,"Unlike EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, this enzyme retains its anomeric configuration. Vanadate is a strong competitive inhibitor of this reversible reaction.",384,1.0,0.054295726,-0.029446114,-0.08082901,-0.05380035,0.04788294,0.019874072,-0.029845444,-0.0035988637,-0.004406937,0.028574623,0.028831918,-0.01441632,-0.103945784,0.033406578,-0.024802905,-0.029160464,-0.044001687,-0.07888718,0.047970492,-0.04895887,0.013955418,-0.011715757,0.0006554446,-0.013492241,0.012368826,0.041917965,0.036120962,-0.010753086,-0.049372066,-0.13487326,-0.016119849,-0.03030741,0.03493277,0.010188688,-0.021524526,0.051083658,-0.113265336,-0.069800936,-0.023873907,0.069130436,0.023781482,-0.023229934,-0.019065982,-0.038414937,-0.055772904,0.0098183,-0.008337483,-0.04319881,0.01210932,0.05402647,0.0034240964,-0.060496327,0.0043349536,-0.009936178,-0.0268256,0.101486124,-0.02952802,0.06870055,-0.08137683,0.021024559,0.11128842,0.03467607,-0.028679734,0.030613042,0.019682255,-0.028887643,0.07518055,-0.09077099,-0.005676924,-0.041696016,-0.04392046,-0.040541746,0.013097805,0.062059864,0.012400145,0.047379553,0.020806326,-0.09419897,0.049000844,-0.00624463,0.066790745,-0.035295717,-0.004029224,0.07290721,-0.02403021,-0.020717952,0.02846076,-0.08715239,0.097209245,0.038762737,0.074851364,0.036039557,0.024811598,-0.03435797,-0.0027367093,0.0743006,-0.003153932,0.011452816,0.004200291,-0.030510848,0.025201606,0.07929932,-0.03288797,-0.032859072,-0.059217986,-0.00798933,0.03753824,-0.0010825311,-0.007944013,0.0699421,0.03352169,-0.023352314,0.15431198,0.03581129,0.0032941697,0.067365386,-0.0059004324,-0.028875893,0.007847077,-0.04425535,0.05177204,-0.016116511,0.062426023,0.083072744,-0.042296115,0.07758021,-0.09925067,1.5825535e-34,0.019331349,0.08106881,-0.034207407,-0.026528262,-0.00015463309,-0.028151385,-0.10075978,-0.019039875,-0.09593666,-0.08202968,-0.09984806,-0.0010883964,0.018421344,0.050895702,0.027906356,-0.074223176,0.0565728,0.11553881,-0.02015056,-0.016999936,0.020478377,0.08946423,-0.026457094,-0.009364276,0.010742731,-0.010987415,-0.017711934,0.026813863,0.024275078,-0.010832791,-0.011071551,-0.0001811437,-0.0555092,0.013794184,0.013433329,-0.011186076,-0.07285022,-0.013310448,0.005084239,-0.004913776,0.033410896,0.08987924,0.014328057,-0.049114205,0.036741406,-0.14861114,-0.08717764,0.08004432,0.015518942,0.01797159,-0.019862713,-0.016908057,0.017469386,0.025144892,0.036952525,0.010320614,-0.030148676,0.04172868,0.044384763,0.03654035,0.016995277,0.07905872,-0.03735675,-0.032446295,-0.028423578,0.06021309,-0.048883397,-0.10916362,-0.029900283,-0.0012957958,-0.04102245,-0.013434917,0.122082524,-0.013437136,0.03143548,-0.087915875,-0.01912439,0.026001543,-0.06208064,-0.027910054,-0.079407245,-0.020336125,0.044133775,0.0277415,-0.018357556,-0.09152408,0.06264731,0.010618733,-0.038832746,0.020127937,0.02588314,-0.029554348,-0.072797865,0.050810795,0.056197982,-3.2534495e-34,0.098344006,-0.12507686,0.008317035,-0.042371146,-0.037047733,0.07638911,0.021796687,-0.022158818,0.011604822,-0.07794779,0.09459845,-0.0007937099,0.03328421,-0.11212131,0.07872325,-0.07131717,0.051580977,0.083726674,-0.031629812,-0.05422726,0.0172486,0.077601545,0.010806687,0.062056243,0.096297845,-0.057763394,0.01274327,0.0701473,-0.042568985,-0.018705923,-0.020303655,-0.008841576,0.008236939,-0.011479182,-0.027998555,0.06669423,-0.009533581,-0.021166053,-0.015062725,0.0760273,0.023357823,0.050961524,0.01874297,0.022968536,0.05454642,0.042080283,-0.049184766,0.030261828,0.005603251,-0.0065973364,0.030713897,-0.03034701,0.033508454,-0.007953233,0.050039962,0.07326707,-0.013657334,0.0609489,-0.022533534,-0.015360359,-0.03687156,-0.01535377,0.05550412,0.013108512,0.03198013,-0.0056910613,-0.07796128,0.05271872,0.06975466,-0.01462033,0.030237427,0.0576895,-0.01861053,0.05128232,0.011711357,-0.08978956,-0.062353738,-0.009613057,0.052616306,-0.070245154,-0.053986277,0.07540656,0.043805823,-0.013922334,0.018040065,-0.009183915,-0.008066866,0.08497735,-0.041938793,0.05667589,0.009921763,-0.12883048,-0.0529754,0.043550633,0.1272572,-3.0788012e-08,0.06211169,-0.04364727,0.013945825,-0.024838816,0.020433834,0.035973523,0.02256283,0.02187094,0.055007417,-0.096089005,0.012305631,0.070163995,0.03352539,0.0499646,0.021567479,0.067265615,-0.009942317,0.051818922,-0.06369959,0.022508442,-0.03444339,-0.04385619,-0.13195917,0.021435952,0.039133567,0.001407384,-0.02946656,0.03179323,-0.09219371,-0.016464803,-0.011600869,-0.009505226,0.07209425,-0.042292822,-0.009984623,0.06958921,0.025540909,-0.020502707,-0.058290776,0.01904776,0.005937016,-0.06989225,-0.031750754,0.022007538,-0.03474742,-0.004758605,0.038287565,-0.031947225,0.008407894,-0.06467612,0.022089709,0.027397929,-0.0002541574,-0.07973901,-0.043216553,-0.042621303,-0.041372262,-0.054904524,0.021945678,-0.026929261,0.12170813,-0.0050254297,0.13621813,-0.06732232 +2.4.1.232,"Requires Mn2+. In Saccharomyces cerevisiae, this enzyme catalyses an essential step in the outer chain elongation of N-linked oligosaccharides. Man8GlcNAc and Man9GlcNAc are equally good substrates.",384,0.99999994,-0.03166444,-0.080054075,-0.0518771,-0.014240718,0.059273336,-0.006887503,-0.022614907,-0.0016035262,0.00297093,0.048082147,0.028840058,-0.022884065,-0.051192567,0.01581673,-0.049436808,-0.006075117,-0.034441356,-0.010045048,0.05096038,-0.04790978,0.11649941,0.015313659,0.013814717,-0.08412848,0.034075275,-0.07566914,-0.010635363,-0.04206956,0.033891816,-0.11593364,0.01947847,-0.008119252,0.04819691,-0.07676593,0.026968746,0.09258007,0.07690152,-0.0021024453,-0.00675757,-0.029992722,-0.0061482745,-0.038464244,0.020312168,-0.0046059494,-0.055599738,-0.01740343,0.04904635,-0.03658238,0.0010128667,0.028277213,-0.046160176,-0.086590186,-0.03460244,0.017361272,0.077401035,0.038165998,-0.09820612,-0.00069873815,0.04995191,0.023368131,0.037381906,-0.032372925,-0.019097362,-0.010040332,0.054824263,-0.06008154,0.050797526,-0.003119669,-0.05310293,0.12109217,0.05052652,0.029168352,-0.09983889,0.011243724,0.036351815,0.07580833,-0.022559958,-0.082671314,0.013151369,0.0050368756,-0.027103702,0.06670961,0.076721415,0.07473846,0.022347432,0.015263058,0.022609001,0.02733703,0.04984278,0.041380815,0.0035357056,0.041826475,0.014621266,0.038062252,-0.020819599,-0.0010358712,-0.0024382644,0.046936035,0.0010463548,-0.008624217,0.050426446,0.024343144,0.00023906224,-0.028358387,0.024242919,0.047712322,0.026971944,0.097669914,0.02597548,0.0804467,0.042180844,0.052794185,-0.025281657,-0.014275882,-0.07427533,0.014742547,0.026259214,-0.10187733,-0.062178865,-0.009640282,-0.022051845,0.09251742,-0.023071425,0.02755449,-0.093094,0.048951495,-0.019577498,3.9692995e-33,0.0082575865,0.050355308,0.0061221016,0.010586769,-0.005649559,-0.009710134,-0.06209512,-0.053660046,-0.0020102412,-0.07696817,-0.058974367,-0.047266144,-0.022109967,0.11492717,-0.019933082,-0.05949222,0.06654899,-0.014421139,0.033461686,0.029750342,-0.041909933,0.0166396,-0.038116172,-0.07027807,0.08671165,0.011476792,0.064169504,0.015732056,0.03574068,-0.033195354,0.0420463,-0.06922359,-0.053121038,-0.016013993,0.09538596,0.015207033,-0.008582194,-0.03893644,-0.02252283,-0.0020739213,0.0041802204,0.061290115,-0.04252179,0.0017284135,0.038944725,-0.019052267,0.026546605,0.029697457,-0.06251728,0.041207064,0.048712473,0.03317749,-0.023844814,0.054223314,-0.04483021,0.029452756,-0.011009003,-0.02252116,0.0028689248,0.07254165,-0.05194442,-0.03287691,0.0399725,0.082209885,0.027584556,-0.012129325,-0.079133086,-0.04179584,-0.0522365,0.024534576,-0.054807667,-0.125997,0.070803694,0.048752148,-0.0042727175,-0.04643996,-0.11245256,-0.040815957,0.015109173,0.009703369,0.04635422,-0.06034335,-0.048539262,-0.05182286,-0.11964048,0.022762993,0.0055473763,-0.0807302,-0.026885692,0.04164894,0.006507664,-0.04805016,0.0356025,0.07965307,-0.026064262,-5.9754874e-33,0.09035731,-0.045619406,0.15365186,-0.076563284,-0.12509693,0.039246537,0.03800203,-0.113565944,-0.063613124,-0.04574136,0.05051844,-0.020529248,0.049568444,0.004175935,-0.005424483,-0.06478811,0.0057299803,0.1209852,0.06578509,-0.007140589,0.03272611,0.110137805,-0.019822976,0.021412881,0.04987895,0.013944807,0.0035783998,0.117159024,-0.017956859,0.048671257,-0.036629062,-0.051505618,-0.02202448,-0.040731072,0.018212017,0.060445197,0.0059851157,-0.0062649716,0.019360365,0.004209774,0.026102446,0.056707002,-0.0636165,0.03571529,-0.05651615,0.027381107,-0.08287159,0.074285865,-0.029507143,-0.041073583,-0.01884366,0.026332848,-0.108244866,-0.061854146,0.051906805,0.031993557,0.026347822,0.007896115,0.07151069,-0.047515184,-0.056860343,0.022863327,0.037502594,-0.046993315,0.055652753,0.054358486,0.012063672,-0.02043631,-0.0063665663,0.014819464,-0.009376578,0.03361812,0.01529984,0.0065510585,-0.028609553,-0.009054347,-0.07656023,-0.023593666,-0.011536294,-0.066347204,-0.031162823,-0.044811968,0.0405068,-0.027859168,0.024251666,-0.056311227,0.11454374,0.03862806,-0.02698575,0.06855797,0.000584716,-0.07372909,-0.03962424,0.06183204,0.014782623,-3.323523e-08,0.022975236,-0.06339876,0.02629386,-0.10839645,-0.06337349,-0.022248562,0.0122580305,-0.027457388,0.04623046,0.031652395,-0.00017428465,0.09179526,0.003853606,0.05727206,0.061579157,-0.00709296,-0.001420038,-0.004787667,-0.03679099,-0.022977296,-0.11404986,0.011022522,-0.09383997,0.077173494,-0.042763967,-0.018420614,0.06803338,0.10180527,0.043944623,-0.059045028,0.022112416,0.0744578,0.0016282193,-0.062072996,-0.013010441,0.07413581,-0.05630901,-0.01602178,0.009606731,-3.190122e-05,-0.036695845,0.028711567,0.017805768,-0.0143637,-0.045468688,-0.0533791,-0.018691516,0.0767165,-0.05423352,0.07596492,0.02356301,-0.04250481,-0.02232686,-0.09261538,-0.050468642,-0.051759657,-0.047976226,0.012484066,-0.07486307,-0.01583934,0.010722175,-0.046936724,0.092840336,-0.15247735 +2.4.1.234,"Acts on the endogenous flavonols kaempferol and quercetin, to a lesser extent on myricetin and fisetin, and weakly on galangin and isorhamnetin. The reaction can occur equally well in both directions.",384,0.99999994,-0.070074305,-0.14427246,-0.079955705,0.10961067,0.03278892,0.08142885,0.008391767,0.023026137,0.05460942,-0.008113547,-0.008438058,-0.0005532126,-0.102875754,0.0038316853,-0.08623042,-0.022438517,-0.00549121,0.0542687,-0.017785974,0.022373943,0.049171984,-0.06982406,0.06804336,-0.02729982,0.016723588,0.049737338,-0.014358784,0.012800509,0.04039827,-0.1117555,0.055470116,0.011586283,-0.0028510431,0.013157018,-0.083169505,0.058394007,-0.08092874,-0.07383989,0.008092118,-0.040413644,0.084672496,-0.059806596,-0.035506856,-0.016870074,0.0501377,-0.10496605,-0.07070178,0.028467035,0.0043133968,0.04960934,-0.02834558,-0.07125677,-0.044863567,0.062704116,0.06292568,0.031101884,-0.03316528,0.020363435,0.03663505,0.043802977,0.05055897,0.0076286867,-0.00054880895,0.020732159,-0.038282376,-0.024533862,-0.028082917,0.06202264,0.013456236,0.027605042,0.041481864,-0.017847696,-0.07017129,-0.014721476,0.024367154,0.07542098,-0.03140248,-0.020725612,-0.105880104,-0.014028595,0.01299174,-0.057783175,0.024907816,0.008501991,0.016517593,-0.07118122,-0.019919386,-0.027818926,0.044214316,0.119177476,0.053383525,0.09677677,-0.00016371219,-0.016262732,0.016115384,0.006199762,0.05531689,-0.033099893,-0.0420892,0.0079989135,-0.008006705,-0.06941392,-0.064886175,-0.031201465,-0.026059285,0.028743075,-0.033376794,-0.098025225,0.015518427,-0.024655117,-0.040315066,-0.08162863,-0.0036131684,-0.020401806,0.047774583,0.055121165,0.07473031,0.0078103007,-0.045507647,0.0016847957,-0.039087772,0.028162383,-0.014951719,0.04439442,-0.04181778,-0.03439683,0.016358718,3.926019e-33,0.062062807,-0.008170833,-0.061081097,-0.0022145829,0.0642447,-0.03808634,-0.017319039,-0.026803182,0.001743848,-0.030783642,-0.084039785,0.00653076,-0.02889624,0.0013016532,-0.0143712675,0.014684855,0.00038895104,-0.039588418,0.06221701,-0.0043089944,0.04611724,0.0070084534,-0.098531164,0.031595256,-0.0026903343,0.052109417,0.0010803373,0.048376393,-0.03003361,-0.012070855,0.011054723,-0.048958432,-0.01963555,0.032020677,-0.027070927,0.07374915,-0.0751845,-0.037312195,-0.0351003,0.016576624,-0.031228222,-0.0027209981,-0.03606136,-0.006102043,0.005426206,-0.065694824,-0.04158544,0.045252074,0.07832059,0.020998217,0.039424907,-0.06687131,0.09909494,0.053887982,-0.00078635564,0.11089975,-0.055932473,-0.00594923,0.04780111,0.021030191,0.03423933,-0.041337993,0.022541769,0.032635566,-0.012701941,0.103924006,-0.079485215,-0.046584018,-0.03355809,-0.0072008776,-0.027390579,-0.022698691,0.084791884,0.015791247,0.10126761,0.031636924,-0.10087415,0.007213708,-0.053120866,0.046974268,-0.01941101,0.037219804,-0.035903938,0.054333135,-0.037188392,0.049069546,-0.02983499,-0.019417722,0.06170444,0.059856128,0.02143286,-0.09311502,-0.0030279628,0.02650265,0.030019954,-4.810642e-33,0.048247647,-0.06087543,0.04147554,0.04958702,-0.0678712,0.09016559,-0.008803511,-0.06690731,-0.03323343,0.038750805,0.08094145,-0.055825554,-0.021941453,0.01553742,-0.07011109,-0.007343771,0.10149742,0.075788245,0.0033388452,-0.03738364,-0.07324306,0.035321724,-0.0051574367,0.049688637,0.0858412,-0.021097537,0.04457233,-0.03548141,-0.086350664,0.097721055,0.008782105,-0.030647906,-0.07152171,-0.085489504,0.0064186268,0.08195024,-0.045320548,0.018751811,-0.06618383,-0.0063686497,0.010824135,-0.014421255,0.07578565,0.111021556,0.053682156,-0.0071079223,-0.051769003,-0.044343755,-0.027985288,-0.009703332,-0.0014442207,0.098637305,-0.031192206,0.07831369,0.050423775,0.03144763,0.073489875,0.004824963,0.056184903,-0.036256,-0.0427893,-0.06989424,0.03263175,-0.08526657,0.11964196,0.051961873,-0.013823092,0.07749929,0.108277306,-0.08900711,0.07581101,-0.07894919,0.055847876,0.11928923,0.033643737,-0.012182651,0.022383058,0.022999601,0.00057214056,-0.049749568,0.003116018,-0.02942349,-0.018294616,-0.104927406,-0.10387221,-0.044281453,0.022830302,0.026645342,0.01953189,-0.007829077,-0.0061225034,0.03652211,-0.023922533,-0.08282852,0.037933644,-3.4158138e-08,-0.008969118,-0.01615917,0.041954987,0.024794322,0.038897682,-0.026012922,-0.042869437,-0.0005650137,-0.069667816,-0.051831983,-0.07174625,0.100188605,0.08512871,0.0057750666,0.019221032,0.025332162,-0.011712803,0.015560706,-0.0032213612,-0.05746771,-0.06818462,0.009212752,-0.08684542,-0.004533096,0.006055111,-0.010625742,-0.0013417929,0.09480303,0.077142626,-0.02602616,0.10665463,0.014898793,-0.04313054,0.007648221,-0.100133955,0.063288584,-0.0020991322,0.008395136,0.0042352066,-0.032727156,-0.12596516,-0.016299015,0.008007747,0.019059138,-0.094152965,0.027494613,0.06904531,0.0065883077,0.014447133,0.004985956,0.0059817163,-0.04059021,0.00822085,-0.0016560536,-0.026102616,-0.018203117,0.10395002,0.0046180724,-0.0031335321,-0.03676728,-0.033896707,-0.06410071,0.020201093,0.023802431 +2.4.1.235,Also acts on pelargonidin-3-rutinoside. The enzyme does not catalyse the glucosylation of the 5-hydroxy group of cyanidin-3-glucoside.,384,0.99999994,-0.10466165,-0.1115701,-0.103231415,0.015180414,0.05142712,-0.007115932,0.037747778,-0.0049286876,0.042121604,-0.007775112,0.04542517,-0.00045388628,-0.117124476,0.06479704,-0.053929433,0.0065363063,-0.07158358,0.069845796,-0.035480887,-0.02802878,0.043252885,-0.047882743,0.04254651,0.027683675,0.025178758,0.050030872,0.051838428,-0.0010218411,-0.0041031945,-0.04487177,-0.08512996,-0.042573545,0.038656022,-0.0013093682,0.017193086,0.06733305,-0.08318795,-0.060791276,-0.04106464,0.0072093806,0.0016739181,-0.004792056,-0.030444652,-0.026535561,0.04131936,-0.041598935,-0.028755855,0.027220936,0.020568993,-0.020852018,0.010131328,-0.037461296,0.0008686285,-0.012875676,0.0045719864,0.008053707,-0.111499645,-0.042161226,0.0283297,0.069991656,0.04111114,0.01555192,-0.09027656,0.012102011,-0.06768589,-0.019068522,0.025348708,-0.07659052,-0.050126173,0.014466535,0.00040244652,-0.0649791,0.012699783,-0.05886708,0.009302992,0.052389205,-0.022565782,-0.018090617,-0.07077426,-0.04361446,0.08194552,0.016001824,0.002690829,0.07079221,0.03899528,0.011042759,-0.011638729,-0.0093944995,0.009629142,0.059123915,0.047917567,0.056652978,-0.03252223,0.03411795,-0.060454078,0.047381394,0.0028447,-0.020580117,0.020051502,0.00038288275,-0.026747521,0.055413738,0.044877436,-0.11655957,-0.063846804,0.06964089,-0.013312098,0.0548442,0.0043639066,-0.014013385,-0.053201545,0.028916903,-0.0012468372,-0.0097795585,-0.056318812,0.08461387,0.041362625,-0.028087795,-0.04071241,0.05410461,-0.043724336,0.015055437,-0.03229575,0.045085624,-0.0762953,0.04427628,-0.025780814,2.5503441e-33,0.015571683,0.003419031,-0.040900476,-0.010343179,0.0345304,0.06919517,-0.03191593,-0.0073260963,-0.009421725,-0.0020217358,-0.064418405,-0.040505655,0.05701206,-0.0029456744,-0.0686347,0.032117244,-0.029111922,-0.035119124,0.08139574,-0.010850045,0.13626423,0.023946157,-0.13844784,-0.09059037,-0.07926205,0.055544943,0.042116605,0.053533707,0.04730217,-0.02332971,-0.013260304,-0.093079224,-0.034533408,0.0074781897,0.042599775,0.054800354,-0.0037687714,-0.0659111,-0.0169786,0.08558707,-0.012334361,-0.060032826,-0.07241212,-0.007658304,0.052673586,-0.0578694,-0.04494913,0.10558171,0.0011861989,0.086380385,0.11164313,-0.040853437,0.055183843,0.077933915,-0.054306883,0.05764493,-0.037830286,-0.01816059,0.04360942,0.015184184,0.054659802,0.032074537,-0.02467364,-0.06036962,0.009548079,0.07026252,-0.076482296,-0.018608632,-0.02921893,-0.009379509,-0.05207044,-0.0079464475,0.06825422,0.08483741,0.07953196,-0.019706268,-0.067388944,0.10918989,0.045777034,0.053775,-0.062589765,0.0050998977,0.08415625,0.08989622,-0.042086862,0.0484153,-0.025098054,-0.059455562,0.002038794,0.024844605,0.07299131,-0.13985574,-0.06373643,0.08462314,0.02709679,-3.0497055e-33,0.10366443,-0.09241565,0.05279994,-0.057758406,-0.0047722277,0.014753481,-0.017342933,-0.052258756,-0.01705856,-0.011262144,0.07603655,0.0034360301,0.028007066,0.0016861606,0.005062513,0.023540089,0.012535761,0.03850451,-0.086034924,0.015097372,-0.013963156,0.010347938,0.0015248184,0.06233198,0.06861039,0.019873712,0.08512145,-0.0022850498,-0.022390435,0.07908946,-0.022271441,-0.039450146,-0.071873546,-0.04769265,0.044749267,0.05330227,-0.023389779,-0.011934333,-0.010219025,-0.022850966,-0.0507055,0.009111757,0.02531357,0.07217761,0.08820618,0.1211891,-0.0062362207,0.0073422296,-0.07069441,-0.013299002,0.03040902,0.07173034,-0.007779604,0.01814987,0.077963166,0.050344482,0.076895274,-0.07245036,-0.0045840014,0.052622493,-0.046541553,-0.053143624,0.025676582,-0.016339201,0.08648391,0.07187822,0.019244611,0.09751674,0.07218869,-0.028549967,0.0412993,-0.039952386,0.032608893,0.032998387,-0.07058854,0.03159743,0.04055701,-0.051065937,-0.004060398,-0.037199777,0.08788521,-0.07679282,-0.013891027,-0.0497616,-0.03147729,-0.09498679,0.032378297,0.07045263,-0.010477721,-0.0029535808,-0.009826358,0.024990804,-0.014701784,0.031877656,0.1259493,-2.969907e-08,0.004391229,-0.02120423,0.013847763,-0.050592527,-0.011167448,0.022549847,0.0016552068,0.019091435,-0.023266947,-0.06072267,-0.026402134,0.016620884,-0.023031129,0.025357291,0.036975376,0.056329604,0.018787375,-0.007754726,0.022421828,-0.0070698755,-0.12137098,-0.0043310514,-0.09295742,-0.001822863,-0.004784262,-0.10298206,0.047440108,0.050626677,0.004321224,-0.02112422,0.046866324,0.04030435,-0.044911318,0.041279357,-0.0056078946,0.04956935,-0.04365652,-0.018121505,-0.062904194,-0.031438176,-0.046834957,-0.007898052,-0.012758413,-0.020633899,-0.04499548,0.011838326,-0.06466913,-0.0024141648,-0.003130568,0.036374927,0.07429095,-0.024905303,-0.002750401,-0.03373314,-0.07617132,-0.050616775,0.05255622,-0.0713613,0.0013288055,-0.015307186,-0.10881481,-0.015220735,0.13867936,0.04364866 +2.4.1.236,"Acts on the 7-O-glucoside of naringenin and hesperetin, also the flavone 7-O-glucosides of luteolin and apigenin.",384,1.0,-0.02619209,-0.06323515,-0.044548467,0.065313324,0.052990563,0.041870918,-0.0010681349,0.07366065,0.0060003162,-0.033235144,-0.03393441,0.06317388,-0.056513283,0.008854712,-0.054514796,-0.016297935,-0.031786248,0.043065052,-0.104134955,-0.022164153,0.060858697,-0.036648728,0.05599958,-0.045917027,0.0058860993,0.0054080808,0.036251493,-0.010984206,0.032093655,-0.08566725,0.07646841,0.036519896,0.018151758,0.045577034,-0.050845753,0.009456929,-0.015771318,-0.048370138,0.0038446323,-0.017294694,0.045887426,-0.028939925,0.04567492,-0.05041403,0.030586058,-0.08909002,-0.09425858,0.02848345,0.048912924,0.11843562,-0.032511223,-0.054453127,-0.060971633,0.0043926593,0.016287271,0.0119882645,-0.09584499,-0.073819615,0.010160752,0.039619934,0.08629001,-0.005338864,0.010978272,0.01363821,-0.1196454,0.003383914,0.014918026,0.021399533,-0.023471527,-0.03062894,0.045891233,-0.0380664,-0.0086414,0.050118476,0.083809495,0.062292494,-0.009899559,-0.0010018311,-0.090102494,-0.05990599,0.12697172,-0.017752346,0.066493526,0.09461788,0.019548513,-0.012032876,-0.07436533,0.017799696,0.035307985,0.044477966,0.0074824747,0.008481624,0.010989243,-0.019455427,0.024771756,0.0292685,-0.0136737935,-7.194291e-05,-0.106331855,0.039050825,0.005137357,-0.012407825,0.00734335,0.017684398,-0.012620612,0.046030704,-0.013581784,-0.043646626,-0.0042610075,-0.042901356,0.026096126,-0.04094241,0.04995757,-0.11874495,-0.037867755,0.030651465,-0.010849251,0.020667441,-0.056127135,-0.016664641,0.0148768,0.06395661,0.056065444,0.04694134,-0.011069874,-0.057763394,0.0037194565,1.6357252e-33,0.06967212,-0.0327519,-0.024866875,0.041180056,0.046698667,-0.03619458,0.03640168,0.016278638,0.014695497,-0.043212328,-0.18619627,-0.0046771243,0.0009537577,0.032862257,-0.012646771,0.032144375,0.020270254,-0.09973841,0.02242845,-0.038764033,0.034335736,-0.026416238,-0.065583125,0.06459186,-0.025943123,0.02842039,-0.047789127,0.058300715,0.008026127,-0.036983725,-0.006314185,-0.044913262,0.035427794,0.095727384,0.02542404,0.09716183,-0.09700062,-0.04221219,-0.009728226,0.07496971,-0.0006214224,0.034016162,-0.02907766,0.0229394,0.014538346,-0.009012005,-0.07790744,0.054400608,0.04443092,0.064034306,0.10104357,-0.024300667,0.036452714,0.09349012,-0.040757786,0.08289852,0.0038827902,0.013185704,0.04601032,0.0469834,0.04014591,-0.011434425,-0.019320982,0.03607797,0.023480317,0.10449472,-0.008441556,-0.004610199,-0.060286365,0.026492942,-0.009177207,0.003121742,0.05099648,0.06502492,0.07445094,-0.020037198,-0.028695647,-0.017314516,-0.04751555,0.010240465,0.056939375,-0.029138306,-0.007909918,0.089958206,-0.09229965,0.041740287,-0.02153278,-0.076873064,0.003218475,-0.032401852,-0.008971381,-0.04629833,-0.053143207,-0.01180302,-0.010266891,-1.8860597e-33,0.018189158,-0.048448693,0.014524096,0.0989544,-0.06425341,0.0652488,0.023051362,-0.0198082,-0.050247476,0.011774771,0.05278279,-0.06113178,0.037702993,-0.029265344,-0.042147793,0.03102661,-0.013300105,0.09790373,0.0011373307,-0.02180283,-0.11262661,0.020102335,0.0060214642,0.03827469,0.050007723,-0.04252442,0.055601686,-0.090161294,0.0050921207,0.09395142,0.011133794,-0.025846235,-0.03857385,-0.066511706,-0.024481606,0.11291332,0.023894647,-0.033263523,-0.07102346,-0.042505004,-0.030399121,-0.04456718,0.0411493,-0.01262959,0.08655884,0.09230878,-0.077483214,0.042497605,-0.075322896,-0.03667832,0.044931233,0.04771918,0.01607991,-0.016436148,0.06649463,0.02297318,0.09816661,-0.061571047,0.057906404,-0.00035763823,-0.0071356674,-0.040800434,-0.014468924,-0.01302017,0.050216272,0.068669386,-0.00815818,0.0568856,-0.0022238363,-0.022512756,0.035398737,-0.09805786,0.008348548,0.057770837,-0.0015409739,-0.04532127,-0.021401199,0.0048077838,-0.024410613,-0.0051843612,-0.0051991995,-0.06559742,0.03108586,-0.057587743,-0.07521965,-0.02580826,0.052336887,0.024957387,0.08125513,0.062298883,-0.009241244,0.029703423,-0.08417561,-0.076335795,0.0054938793,-2.897856e-08,0.06233377,-0.034453742,0.025492124,-0.016752463,0.007552165,0.016247962,0.015491855,0.0016707154,-0.032461356,0.0285245,-0.002130617,0.08982971,-0.04867606,-0.013522919,-0.0173537,0.029800074,0.037368815,0.041714568,-0.020774486,0.017183382,-0.050643943,0.03467069,-0.020042922,-0.06476904,0.04967538,-0.14764622,-0.014400763,0.06579472,0.10283341,-0.020672236,0.00013886535,-0.00973842,0.030579304,-0.14083637,-0.116488665,0.021244647,0.012239233,-0.026820773,0.07763477,0.008243137,-0.07852385,0.039417252,0.022981854,-0.0008474436,-0.054496363,0.015722184,0.041642394,0.008703065,0.02348219,-0.0017832243,-0.035542864,0.020595588,0.021433596,-0.05123202,-0.11026031,-0.080374315,0.010201351,-0.011328323,0.08786518,-0.16539215,-0.075424835,-0.00046961315,0.07406078,0.06096913 +2.4.1.237,"Acts on the flavonols gossypetin (8-hydroxyquercetin) and to a lesser extent on quercetin, kaempferol and myricetin. ",384,1.0,-0.072938025,-0.0928619,-0.04833745,0.09038696,0.015155566,0.0823324,0.06334326,0.076915,0.04570628,-0.07945567,-0.03619548,0.031013008,-0.06870804,0.039905623,-0.101213194,-0.024867905,-0.013305636,0.036924716,-0.05339999,-0.014831175,-0.011627256,-0.06625238,0.09304358,0.01799708,-0.0050192694,0.031460293,-0.048013233,0.035965934,0.013302761,-0.085715145,-0.00812653,0.03032987,-0.028892636,0.017571853,-0.08066766,0.031105531,-0.058440596,-0.033157796,0.037048306,0.00823546,0.10939866,-0.06309253,-0.025868375,0.014814679,0.07399589,-0.08158004,-0.074852206,0.0056932475,0.0054273033,0.10601784,-0.064363435,-0.033506006,-0.06971583,0.06799294,0.035975967,0.0076427856,-0.06027427,0.045490902,0.057866044,0.085653506,0.029310321,-0.024128713,0.029239979,0.045784533,-0.052054968,-0.0054661054,-0.03731765,0.053424507,0.02750011,0.025711076,0.019058907,-0.015240642,-0.018225439,0.032867935,0.008260255,0.08437366,-0.04504872,-0.02192611,-0.0866213,-0.021989128,0.03465117,-0.037863206,0.010733136,0.1139136,0.0037521254,-0.083027005,-0.06556196,-0.015970107,0.04454382,0.11403415,0.07335909,0.05453255,-0.003182961,-0.015162296,-0.022121828,0.019184193,0.019210104,-0.04400916,-0.05060684,0.0025872884,-0.022367394,-0.13311905,0.04233331,-0.010919419,-0.0237048,0.0115132285,-0.027519446,-0.13821532,0.048220735,-0.044999085,-0.048716996,-0.022171453,-0.0028927184,-0.05973214,-0.009839876,0.0683544,0.05801221,0.0041280403,-0.050332963,-0.065044016,-0.04732247,0.023593232,0.029346995,0.019366719,-0.05601362,-0.04701959,-0.039232064,3.0348294e-33,0.0445087,-0.007025085,0.00128669,0.047741517,0.03175164,-0.04217867,-0.009058269,-0.021413008,-0.01045018,-0.03012476,-0.046827074,0.010446105,-0.01927396,0.033819664,-0.003152657,0.026360644,0.0036213798,-0.07446539,0.04880859,-0.04408997,0.06281975,0.020443333,-0.102656566,0.031339623,-0.025677882,-0.011899507,0.0060942513,0.040893883,-0.021426277,-0.025151763,-0.03168751,-0.060914196,0.008010681,-0.018566556,-0.0037183084,0.053648416,-0.02922236,-0.051622603,-0.0029451041,0.0020785711,-0.01296071,-0.008435889,-0.021736167,0.014635544,0.009725863,-0.025836254,-0.07443212,0.041398104,0.029567955,0.055970713,0.05702403,-0.08655795,0.082470335,0.09892905,-0.08559349,0.083726145,-0.05327583,-0.017782869,0.04809821,0.031059386,0.06157416,-0.022987034,0.016339883,-0.021529442,0.0070848567,0.071424544,-0.05774894,-0.04514383,-0.035785682,0.008366703,-0.005352021,-0.010728295,0.10350074,-0.009479981,0.12039799,0.027536282,-0.10475427,0.0010372264,-0.047961045,0.09320518,-0.012591834,-0.03011792,0.013882277,0.08425112,-0.060434416,0.011428464,0.038220897,-0.027217934,0.05632713,-0.008877865,0.053740554,-0.11949189,-0.00485677,-0.004665423,-0.005822666,-3.5285347e-33,0.019226685,-0.06999974,0.10787898,0.09197342,0.004586018,0.017148653,0.040504385,-0.02734254,0.0009878565,0.020290893,0.066174574,-0.073549286,0.025749622,-0.024357157,-0.042773858,0.007079432,0.0018506418,0.0911561,0.011965715,0.00067490706,-0.0717561,-0.012866926,-0.019170739,0.075805545,0.06320194,0.0119734965,0.078245185,-0.04557213,-0.06696433,0.0778819,-0.024008486,-0.002284728,-0.079921626,-0.08140798,0.031002417,0.04811961,-0.017289802,0.010982091,-0.071779735,-0.0838923,0.025656626,-0.06029018,0.072239906,0.09408408,0.040939968,0.08661932,-0.049049735,0.032871414,-0.024017135,0.03287276,0.017373815,0.11576493,-0.04792064,0.09710807,0.049650244,0.0051218537,0.0756974,-0.04115213,-0.011185168,0.0153489625,0.004876665,-0.06639066,-0.017715456,-0.045919873,0.08845789,0.052988034,-0.042646658,0.060761455,0.061826155,-0.05103166,0.058418725,-0.09563092,0.04936513,0.08641066,-0.03243509,-0.03303919,0.03888011,0.027769,0.0030616347,0.0042207977,0.04782241,-0.03435622,-0.03202901,-0.11135005,-0.022118941,0.013828842,0.028755883,0.032577503,0.007051516,0.052284896,-0.009912268,0.00089951593,-0.110824935,-0.031309564,-0.00068525947,-3.114913e-08,-0.009356482,-0.0484531,0.043352745,0.0136734955,0.042363912,-0.028715644,-0.03886933,0.028178874,-0.030338451,-0.032133363,-0.024860663,0.016551001,0.017283468,-0.008493737,0.025464945,-0.02798971,0.0053946585,0.07318466,-0.012735305,-0.051246267,-0.07485736,-0.011979969,-0.05386859,-0.02075352,-0.01338051,-0.024061823,-0.007103942,0.07852343,0.095583886,-0.08038491,0.10577497,0.01720403,-0.012167096,-0.003989385,-0.10531438,0.044415623,-0.012537927,0.0143671185,-0.007391037,-0.0030837734,-0.12696281,-0.024982953,-0.0113732265,0.018801752,-0.07622519,-0.039310627,0.055667397,0.030238913,0.076434575,-0.0126188975,0.015844116,0.011205675,0.006305126,-0.038461905,-0.044425722,-0.017376466,0.0723118,0.015940875,-0.037237562,-0.069015294,-0.063075475,-0.08541982,0.09110151,0.046881534 +2.4.1.238,Isolated from the plant Gentiana triflora (clustered gentian).,384,1.0,-0.029552573,-0.002018217,-0.12837492,-0.004739047,0.021378353,0.07131506,-0.027348116,-0.01410157,0.03805715,-0.025919653,0.1857279,-0.08765051,-0.031039912,-0.07317538,-0.061883118,-0.029397834,0.011610964,0.0139315585,0.0059296843,-0.04225287,0.004599318,0.07490585,0.017142596,-0.024853598,-0.03885641,0.02216336,-0.03146206,0.08696021,0.042197067,-0.06763801,-0.009736995,0.10614195,-0.0075964364,-0.017790485,0.03255514,0.05101939,-0.041434307,-0.007688274,0.13271415,0.09615063,-0.047772344,-0.031488124,0.05429239,-0.04205152,-0.00018843023,0.014278506,-0.11155738,0.043075725,0.061045334,-0.013062657,-0.020267816,0.010452912,0.056637865,0.058516264,-0.010043999,-0.016342541,0.06655888,-0.044047263,0.0022643537,0.06364678,0.07486203,-0.01869825,-0.016919874,0.015079091,-0.081170835,0.05997916,-0.0075080884,-0.04527223,0.10249631,-0.070614375,0.011612798,-0.026972558,-0.012986261,0.03943548,-0.0999536,0.06028371,0.010351827,-0.030469967,-0.01486261,0.02164072,-0.0029542984,0.051123716,0.07165249,-0.001789941,-0.023404067,-0.034446254,0.032052074,0.07620928,0.013679909,0.007861129,-0.018021293,0.11309416,0.084703565,0.029069249,-0.04237789,0.052572135,0.050870262,-0.04480146,0.010313913,-0.039545394,0.026228596,-0.06188861,0.03888106,-0.04405864,-0.11114984,0.0023112092,-0.03114619,-0.03764578,0.095981546,-0.01604379,-0.077969484,0.033154838,-0.07556266,-0.0177765,-0.07330853,-0.008490761,0.12810802,-0.040812925,0.028517608,-0.0036904383,-0.024283823,-0.032446515,0.033855516,-0.015816862,0.046530753,0.06564672,-0.094003394,-3.978766e-34,-0.008489563,0.03135461,-0.051299214,0.009517888,0.008413223,-0.01579173,0.034029044,-0.0384349,-0.07942479,-0.06464239,-0.10016735,-0.01708545,-0.051944528,-0.019910403,-0.05407421,0.028782723,0.01584378,-0.011820854,0.023641376,-0.026317421,0.00081136747,0.12005613,-0.01958669,-0.025520481,0.037224013,-8.5414715e-05,0.04247062,-0.10084382,0.075920105,-0.0017211292,0.019230023,-0.104491234,0.028579034,-0.009247857,0.04218231,0.044900723,-0.05498889,-0.060990803,-0.042946298,0.09133756,-0.015308273,0.04731642,0.10674264,-0.02507982,0.053133007,0.051776268,-0.067426585,0.035724636,0.053224735,-0.011271512,0.0330485,0.062260896,0.0004478219,0.022476546,-0.08282719,0.007268437,-0.03202454,0.056165237,0.019804923,0.049544785,0.0011972942,0.09283578,-0.008858851,0.003843027,0.047842667,0.019740842,-0.10412395,-0.0053032585,-0.002027231,-0.014408686,-0.00094428443,-0.08219847,0.030178044,-0.013566227,0.035186645,-0.0043799737,0.014660352,-0.031426325,-0.054233592,-0.02201405,-0.05267332,0.014178535,0.032113705,-0.015575328,-0.059309755,-0.005919161,-0.084554166,0.098203644,-8.920505e-05,-0.059017483,0.097297855,0.037132602,-0.028140774,-0.05157824,0.010228188,-1.9196681e-34,0.011209659,0.03585806,-0.047024146,-0.019685812,-0.0096140755,0.08775254,-0.077241115,-0.010224477,-0.032394662,0.043033235,0.01629952,-0.019780135,0.033593327,-0.064490095,-0.04460996,0.044677954,0.117369555,0.13192557,-0.08361648,-0.025877565,-0.03557664,0.0138079515,0.05147118,-0.005946443,-0.030569129,-0.0034823413,0.037521176,0.037053317,-0.0609156,-0.02658657,0.058222584,-0.03928619,-0.03137129,-0.057275143,0.0197276,-0.017685363,-0.020701945,-0.09103266,0.015155376,-0.02837364,-0.049729344,0.00906324,0.010894128,0.10174814,0.009906417,0.02036819,0.026245259,-0.01293104,-0.047368445,0.07113681,-0.02879518,0.0011442396,0.005370736,-0.035895925,0.04340087,-0.049383186,0.0452988,0.043091286,-0.021786768,0.001176225,0.106807165,-0.011688192,-0.04733008,0.023096772,0.085412644,0.113221124,-0.06985415,0.035318695,-0.022889817,0.028266447,0.0044352924,0.07507842,0.007218417,0.0076944963,-0.023462025,0.077738516,0.0026925001,-0.0774369,-0.0045862324,-0.018928837,0.059224818,-0.05469659,0.024444763,-0.048059482,-0.005962266,-0.06470035,0.059962034,-0.011851861,-0.005025998,-0.026106562,0.003850288,0.0054071066,-0.11141516,-0.037286475,0.10433383,-1.8975786e-08,0.08762007,-0.045677915,-0.024463367,-0.053455412,-0.0060573816,-0.009958539,0.0042930255,0.03257154,0.03366375,0.030013675,-0.02249241,-0.009405005,-0.05247571,0.053616628,0.048144005,-0.043290477,0.019677065,0.08595998,-0.020290783,0.028499411,-0.08574969,0.03272926,-0.061736513,0.00781986,-0.03384714,-0.03010347,0.10017187,-0.056513797,0.10348772,-0.068352275,-0.02953551,0.009760449,-0.10891592,-0.013790691,-0.053577036,0.036943715,-0.04236871,0.07496985,-0.02112623,-0.017179605,0.0059193587,0.0024098167,-0.018573385,0.015660081,-0.053605825,-0.043825235,-0.018440094,0.0073180133,0.041864097,-0.0012259206,0.0032727702,-0.027549934,0.03948439,-0.020446315,-0.04710749,-0.046359796,-0.025418418,0.0034812943,-0.0030863185,-0.027310843,-0.101459816,-0.02593332,0.09909532,0.09489245 +2.4.1.239,"One of three specific glucosyltransferases in pea (Pisum sativum) that successively add a beta-D-glucosyl group first to O-3 of kaempferol, and then to O-2 of the previously added glucosyl group giving the 3-O-sophoroside and then the 3-O-sophorotrioside (see also EC 2.4.1.91, flavonol 3-O-glucosyltransferase and EC 2.4.1.240, flavonol-3-O-glycoside glucosyltransferase). TDP-glucose can replace UDP-glucose as the glucose donor but the reaction proceeds more slowly.",384,0.9999999,-0.0880339,-0.043851957,-0.083504185,-0.006817674,0.03236916,0.07660957,-0.07199983,0.027090956,0.1132305,0.021242706,0.06513519,0.05198011,-0.09728659,-0.07411145,-0.07813547,-0.10731731,-0.035793975,0.04172819,0.014322352,-0.04736728,0.11096373,-0.015190979,0.063829236,-0.012922388,0.10837741,-0.0026539597,-0.040359627,-0.061826304,0.009889241,-0.07503273,-0.07175282,0.022750776,-0.0036455328,-0.022630444,0.04879892,0.08466008,-0.008769105,-0.0557779,0.010456681,-0.0352322,0.05971252,-0.08367409,0.00156779,-0.014606383,0.04133204,-0.044040743,-0.098091744,0.048364095,0.02098322,-0.036364228,-0.008999965,0.0006866861,-0.052283637,0.013125085,0.04231386,0.030148232,-0.037657797,0.045651622,0.0013859997,0.012078142,-0.04027282,0.009335649,-0.0095595,-0.011293582,-0.0061363555,-0.01341511,0.024046497,-0.065018654,-0.0065147183,0.040096436,-0.011735517,0.04522211,-0.0047591077,0.044493303,0.028657759,0.048185002,-0.04526218,0.03420242,-0.029383643,0.024428174,0.08968565,0.038479906,0.036078297,0.049925193,-0.045619063,-0.023131983,-0.0117889065,0.08474173,-0.030725103,0.00090712256,0.005714907,0.03228171,-0.017543854,0.05105189,-0.008791964,0.050221063,0.03699702,-0.045284666,0.06987462,-0.08552499,0.027106144,0.026047697,0.056717977,-0.08829527,-0.02570808,0.045682523,-0.036236312,-0.015030447,0.045286987,0.025355306,0.025456307,-0.0037958054,-0.019901624,-0.048940625,-0.14565471,0.041142125,-0.007542901,-0.10167892,-0.060927212,0.00879652,0.0055620037,-0.06965171,0.0121268965,0.07167185,-0.01945081,0.062684424,-0.040803764,5.2669207e-33,0.0656793,0.021462757,-0.009533503,-0.034654535,0.013875877,-0.010985352,-0.0038966357,-0.07852292,-0.054371323,-0.016784268,-0.13662599,-0.04317875,-0.04008971,0.030856146,0.026518414,0.038604498,-0.051783785,-0.028057434,0.10015425,-0.01464485,0.015876755,0.0739345,-0.046178468,-7.843409e-05,0.06375944,0.05909084,-0.08207792,0.013090116,0.0012962699,-0.027332857,0.057859104,-0.054341894,-0.039304316,0.0588972,0.049289085,0.004415344,-0.047293153,-0.10703866,0.006018558,0.108009286,-0.015293087,0.033603776,0.0671967,0.017180154,0.044660755,0.027373657,-0.0028514354,-0.069022454,0.020395953,0.13066056,0.038122613,-0.00609268,0.020536495,0.05821087,-0.048516303,0.017521447,-0.034235016,-0.004890147,0.03971682,0.095908545,0.0008299122,0.050598323,0.06657711,-0.02753522,-0.06498169,-0.014789176,-0.12978542,0.0048151617,-0.06304414,0.020325616,-0.004580485,-0.0929873,0.035762824,0.013101134,0.098064825,-0.020066611,-0.0054136966,0.06860791,-0.005535766,-0.06657947,0.06761603,0.024395583,-0.04032469,-0.033539977,-0.07445982,0.059631374,-0.03859068,-0.0511441,0.0028271538,0.024500811,-0.0012925433,-0.018820604,-0.029515594,0.015119789,-0.029070472,-6.144545e-33,0.061059587,-0.05485591,0.0238735,-0.031618617,-0.036456037,-0.012867651,0.029440835,-0.12806192,0.053471856,0.059584618,0.053913124,0.00028626822,0.033864886,-0.055238776,-0.031709194,0.0027457501,-0.013773009,0.05098558,-0.07024833,0.023635127,-0.009820068,0.09212396,-0.008023086,0.0358888,0.023814354,0.0040477063,0.035984512,0.015941491,-0.0019833427,-0.0036817375,0.05110119,-0.02409709,-0.0970452,-0.006887453,0.01365155,-0.008194453,0.03188796,0.019079458,-0.013671349,0.009896995,-0.0034170728,0.042654306,0.08869429,-0.021098502,0.12136887,0.02764769,-0.034712747,-0.027148597,-0.060592946,-0.011595205,-0.007908295,0.036627553,-0.016449284,0.089232005,0.03258282,0.021337459,0.07641757,0.038440734,-0.028330147,-0.018949954,-0.03168204,-0.120443456,0.061707783,0.019405872,0.09422636,0.0500706,0.051111575,-0.0010738038,0.018880928,0.09105468,-0.038361352,-0.020805473,-0.027614875,0.03155523,0.03209787,-0.013821733,-0.099880114,-0.0135500515,-0.014599594,-0.07087897,-0.014627392,-0.044001512,0.0039629713,-0.073778816,-0.006293673,-0.106737226,0.06776282,0.09066798,0.014002808,0.07131381,0.006246853,0.013607383,-0.007991793,-0.015370814,0.054672834,-4.7780432e-08,0.009052865,0.00718614,-0.038379733,0.0047725528,0.02317021,-0.084642954,0.01086594,0.051544186,0.05511255,-0.075540066,-0.07333206,0.10846886,-0.00604636,-0.072367914,0.06966169,0.008709591,-0.0721102,0.031459372,0.0156511,0.02373736,-0.07959108,0.0017472466,-0.11527198,0.019571895,0.0018955006,-0.011668037,0.106507145,0.031561375,0.043915976,-0.0034410988,0.040397473,0.036505952,-0.03526447,-0.021936594,-0.027496647,-0.042453874,0.016969556,0.031428665,0.02515261,0.05587376,-0.095131755,-0.030612348,-0.015942689,0.02845801,-0.014517703,0.0076606837,0.026012756,-0.0318265,0.015850518,0.058805395,0.04277676,-0.08304047,-0.11018391,-0.10879773,-0.017541941,-0.0633546,0.0032426438,-0.0017706024,0.040512286,-0.025431236,-0.07172077,-0.0011173016,0.14907423,0.022810206 +2.4.1.240,"One of three specific glucosyltransferases in pea (Pisum sativum) thatsuccessively add a beta-D-glucosyl group first to O-3 of kaempferol, and then to O-2 of the previously added glucosyl group giving the 3-O-sophoroside and then the 3-O-sophorotrioside (see also EC 2.4.1.91 flavonol 3-O-glucosyltransferase, and EC 2.4.1.239 flavonol-3-O-glucoside glucosyltransferase).",384,1.0,-0.046237547,-0.063092895,-0.09374105,0.009516965,-0.0033631779,0.08885317,-0.10484101,0.0092675295,0.14914645,-0.010517229,0.10911874,0.025790865,-0.05892637,-0.090345666,-0.10177974,-0.09633659,-0.053416036,0.0718923,-0.019418344,-0.05433335,0.09271874,0.018325847,0.06278861,-0.00027428952,0.086319186,0.006796236,-0.06274056,-0.06365666,0.026420768,-0.082739264,-0.037911702,0.026453283,0.034535702,-0.028799172,0.09043829,0.0048451344,0.0007839774,-0.02834398,0.05813568,-0.0076078265,0.030599825,-0.068623774,0.030434923,-0.03193252,0.016515115,-0.026500044,-0.07973166,0.019488305,0.04121579,-0.014849851,0.021590617,-0.026642915,-0.05842152,0.011717831,0.04500367,0.018059274,-0.040806234,0.025186963,-0.011973927,0.08034448,0.0061716633,0.004892486,-0.028090958,-0.0059155235,-0.04463163,0.01434668,0.040631577,-0.04258344,0.014175039,-0.012640027,0.005215042,0.032848645,0.0040913397,0.06348272,0.013834807,0.076686494,-0.052584138,0.044973828,-0.045303755,0.0048178323,0.10055831,0.04098363,0.037480276,0.027034026,-0.048810866,-0.0090758605,-0.057261825,0.08609165,-0.0095525095,0.031278055,0.0061090724,-0.004047599,0.00916067,0.03971622,0.052241478,0.067878485,0.045961063,-0.015773281,0.035489347,-0.09237889,0.03944178,0.010436919,0.055615686,-0.06949487,-0.014866989,0.03901014,-0.04586766,-0.0065176375,0.02911167,-0.008624719,0.0270172,-0.048924815,-0.041402202,-0.085392684,-0.11571603,0.021251708,0.05145859,-0.07729467,-0.08320575,-0.01791488,0.011651765,-0.0558601,0.010831361,0.092894495,-0.036774628,0.0030697158,-0.054697923,6.202948e-33,0.08254822,0.05541539,0.0117663015,-0.029770043,0.007434521,-0.040185448,-0.0067089815,-0.09340454,-0.054786514,-0.040449798,-0.13944736,-0.047411747,-0.06340519,-0.0033362336,0.05795244,0.05291753,-0.040632162,-0.045176875,0.059763137,-0.027349355,0.034231536,0.03708769,-0.049959857,-0.030121053,0.042327397,0.04921052,-0.045236316,-0.04078321,-0.009264734,-0.038685646,0.018262314,-0.082341745,-0.007456862,0.056793705,0.04711017,-0.005203946,-0.0640979,-0.10407717,-0.0034291896,0.1030074,-0.015720818,0.009634237,0.032998048,0.01626915,0.041641504,-0.0067608454,-0.02900417,-0.02016137,0.024902284,0.13668136,0.029090324,0.022211503,0.027624555,0.086904384,-0.07103496,-0.003221506,-0.02914164,-0.011229662,0.04602057,0.091803774,-0.0012202193,0.061098825,0.054047715,-0.026009332,-0.07812855,-0.0493272,-0.14031199,0.03753712,-0.06884429,0.078362755,0.0074290778,-0.105331816,-0.00021338821,0.017043155,0.12711851,-0.012411402,-0.03994787,0.06639825,-0.02016343,-0.05277737,0.06818959,0.041678574,-0.027281573,0.010481859,-0.11096265,0.08172931,0.008381514,-0.0058772545,-0.009421205,0.05213034,-0.0113357585,-0.025774973,-0.020553047,0.060634017,-0.033532623,-6.0646454e-33,0.03855744,-0.036867812,0.002634011,-0.06468421,-0.053674106,0.0016393053,0.015954379,-0.066241324,0.021028921,0.08499557,0.04101668,-0.019904254,0.031086348,-0.060769178,-0.015889073,-0.043054324,0.013890472,0.047710042,-0.01032148,0.06520142,-0.015096384,0.023402333,-0.0110566495,0.028200336,0.02200094,0.0044856076,0.04448165,-0.01746124,-0.048699886,0.0378095,0.036290348,-0.010428869,-0.06490228,0.008199388,-0.013133192,-0.02707323,0.048049998,0.020183982,-0.009266736,-0.003374002,-0.053763468,0.03448943,0.07648448,0.008611932,0.11755636,0.060611058,-0.012259905,0.00040241264,-0.061229806,-0.021764984,0.012775213,0.019367322,0.022506408,0.10522958,0.050469205,0.004895161,0.09015463,0.0467363,-0.026225045,-0.009430278,-0.041715346,-0.09704281,0.01637374,-0.013607493,0.10867308,0.036885135,0.015054617,0.028221002,-0.018886698,0.056313425,-0.05079478,-0.036539376,-0.018701866,0.020633593,0.045276236,-0.027021315,-0.08930443,-0.008407952,-0.017361304,-0.02212417,-0.022836972,-0.06210516,0.011148255,-0.04389016,-0.0038236335,-0.11337169,0.07623452,0.108881466,0.009404305,0.0792999,0.006039218,0.038934343,-0.03534201,-0.004684029,0.018552281,-4.3716955e-08,-0.011510465,0.0036987672,-0.025671693,-0.012705514,0.0309895,-0.07346496,0.016249152,0.055979047,0.017471002,-0.03337093,-0.044899464,0.031908743,-0.008871437,-0.06995195,0.06229827,0.03396869,-0.04477706,0.059031706,0.047723383,0.021116074,-0.042025927,-0.00457805,-0.06670003,-0.011011257,-0.001526134,-0.014713861,0.11198945,0.054998673,0.034704357,-0.004639309,0.06676238,0.005337575,-0.05551352,-0.072991535,-0.031044189,-0.031684354,0.040430788,0.0066923867,0.03079014,0.046621382,-0.11088853,0.009326332,-0.011688314,0.043401062,0.020080794,-0.024102846,0.018988641,0.00033965695,0.044632886,0.03593506,0.037207462,-0.09714865,-0.0655186,-0.094204076,-0.057229154,-0.068735994,0.053326573,-0.0363709,0.029858015,-0.05251636,-0.052590646,-0.006487288,0.1344182,0.0671789 +2.4.1.241,"Requires Mg2+. Diacylglycerol cannot serve as an acceptor molecule for galactosylation as in the reaction catalysed by EC 2.4.1.46, monogalactosyldiacylglyerol synthase. When phosphate is limiting, phospholipids in plant membranes are reduced but these are replaced, at least in part, by the glycolipids digalactosyldiacylglycerol (DGDG) and sulfoquinovosyldiacylglycerol [3]. While both DGD1 and DGD2 are increased under phosphate-limiting conditions, DGD2 does not contribute significantly under optimal growth conditions. DGD2 is responsible for the synthesis of DGDG molecular species that are rich in C16 fatty acids at sn-1 of diacylglycerol whereas DGD1 leads to molecular species rich in C18 fatty acids [3]. The enzyme has been localized to the outer side of chloroplast envelope membranes.",384,0.99999994,-0.13007921,-0.09362153,0.0066399802,-0.013535638,0.025977852,-0.03911794,-0.037336648,0.006100781,0.054459997,0.007438656,0.023026796,0.021115057,-0.05368207,-0.013357589,0.02845262,-0.016744262,-0.009232845,0.09137816,-0.05890384,-0.006449557,0.15364239,-0.0069318973,-0.044759423,0.006426049,0.028908003,-0.033598896,0.0199347,-0.011450189,-0.029204685,-0.053489503,0.0048938524,-0.030358724,0.029320385,-0.071584776,0.007061107,0.0453428,0.027854767,-0.022493675,-0.02848606,-0.058785867,0.026681965,-0.0044321404,0.0014696248,-0.02070088,-0.022959175,-0.05176029,-0.019349862,0.04249982,-0.016403588,-0.06660428,-0.016265368,-0.028581848,-0.03927919,-0.08938534,0.058698006,0.04294286,-0.05949558,0.07389007,0.012154186,-0.019792149,0.022611147,0.030354261,0.018996777,0.002365031,-0.045361094,-0.07475969,0.030141134,-0.08127892,0.070189446,-0.028190577,-0.07990307,-0.025152422,-0.010913855,0.001044707,-0.016044788,0.08336932,-0.0017228362,-0.05215666,0.06318164,-0.0786523,0.09157343,-0.013347593,0.049421147,0.03144986,-0.037385076,-0.021430185,0.027949994,0.012286723,0.0011683911,0.014045424,0.116246454,-0.012284272,-0.011916967,0.07988212,-0.052765556,0.05136152,0.004552442,-0.054677565,0.001318447,-0.047411676,0.031604633,0.023379322,-0.0058416068,-0.023958962,0.0023806456,0.0456173,-0.061082028,-0.0048219026,0.0032386398,0.0037266952,0.0776105,0.0387855,0.05797781,0.084353864,-0.052702796,0.047252722,-0.026570003,-0.06750475,-0.012016556,-0.0035726458,-0.016751401,-0.06012315,0.022570722,0.0019893884,-0.005737316,0.10131632,-0.032169256,8.62707e-33,0.035608537,0.036469206,-0.0060361153,-0.029987637,-0.048428852,-0.056895528,-0.08299582,0.028016247,-0.057309847,-0.05127715,-0.09019294,-0.056727633,-0.03018953,0.0416324,-0.029308818,-0.0049197413,0.015666198,0.07715908,0.08067277,-0.00260961,-0.05779316,0.052893844,-0.0092720995,-0.02200375,0.09340621,0.039093923,-0.00310486,-0.04995657,0.11360653,0.005877791,0.029564572,-0.15372385,0.007990504,0.08649314,0.022802206,0.06001513,-0.07224687,-0.054791246,0.026360627,-0.033015568,-0.034668628,-0.0016092282,-0.011570379,0.023530541,0.008895505,-0.020897802,-0.062120575,0.018140107,-0.021438194,0.015158598,0.026146043,0.02851905,0.0030822477,0.052713744,-0.0092365155,-0.032233704,-0.018736342,0.024905317,0.06813871,0.042353295,-0.012028485,0.09359265,-0.038601387,0.02506149,0.10420823,0.02315127,-0.104381375,-0.043942124,-0.041910302,0.031053009,0.04779548,-0.0954018,0.08025971,0.07566242,0.033578567,-0.05419117,0.075247504,0.064654194,-0.014109578,0.028851911,0.009280406,0.067861326,-0.014016531,-0.065148935,-0.06491849,-0.006838235,-0.07463909,-0.032744396,0.015660455,0.06291246,-0.063061155,-0.03664583,-0.018643415,0.05472221,0.008627488,-9.253741e-33,0.036846813,-0.014936754,0.094427906,-0.023733903,-0.030057717,0.026243333,0.0045606247,-0.067504875,0.10229255,-0.09084744,0.04093019,0.007422453,0.015565668,-0.033838987,-0.067383684,-0.05052372,-0.015970413,0.0472666,-0.08644771,0.017065672,-0.0155720115,0.098586425,-0.019137163,0.1668592,0.027074294,-0.02676608,-0.012638436,-0.009152099,-0.029402422,0.08477317,0.09779317,0.07039118,-0.0833872,-0.011808241,-0.035502456,-0.03125522,-0.084189996,0.00066734356,-0.031143948,0.11458175,-0.06435405,0.033066947,0.09648085,-0.01485442,0.0794461,0.0213187,0.0015412782,0.0025848055,0.027388867,-0.05155328,-0.035653908,0.03598114,-0.007429652,0.09579734,0.063167974,0.07477793,0.07718521,0.0794906,0.010082152,-0.050115455,-0.045927294,-0.09248569,0.05978472,-0.11601463,0.010814874,0.06818285,-0.0034868603,0.012721754,0.03316242,0.026946265,0.025782814,0.022435268,0.01835058,0.017764654,-0.02277045,0.053903352,-0.07802643,-0.051783003,0.0048996075,-0.04345899,0.010783929,0.1090188,0.019006573,-0.030975917,-0.04127604,-0.05779727,0.0002142188,0.056284674,-0.034320883,0.023609774,-0.043531705,-0.080916084,-0.03375916,-0.0027084732,0.0823586,-4.8424525e-08,0.031080509,-0.039861344,0.02319444,-0.08828242,-0.048901886,-0.023659507,0.016634718,0.036757298,0.060672075,-0.05233973,-0.03556644,0.091058575,-0.013438076,-0.0371996,0.024091829,0.04071943,-0.011643907,-0.0007968817,-0.029968625,-0.025175689,0.018575734,-0.04288892,-0.14703077,0.026124604,0.026365682,-0.09868074,0.030608118,-0.025736205,-0.003930577,0.034504004,0.07603829,0.0018049,-0.040496882,0.013627855,0.07603865,-0.007891732,-0.048189644,-0.010453283,-0.00612884,0.038501546,0.006269563,-0.05190759,0.039542813,0.016600668,-0.060562637,-0.033274435,0.00904109,0.046210814,-0.0920543,0.070108965,-0.015985763,-0.048417963,-0.037380777,-0.13169569,-0.075023554,-0.0033810942,0.014479819,0.013985978,-0.055379905,-0.0034080765,-0.03632951,-0.039688416,0.09706888,-0.019638771 +2.4.1.242,"Unlike EC 2.4.1.11, glycogen(starch) synthase and EC 2.4.1.21, starch synthase, which use UDP-glucose and ADP-glucose, respectively, this enzyme can use either UDP- or ADP-glucose. Mutants that lack the Wx (waxy) allele cannot produce this enzyme, which plays an important role in the normal synthesis of amylose. In such mutants, only amylopectin is produced in the endosperm [3] or pollen [5].",384,1.0,-0.06628189,-0.053008188,-0.060547132,-0.025010636,0.055765,-0.0009489536,-0.015894769,-0.03455511,-0.051936764,0.017705007,0.043842528,-0.020026399,-0.11117535,-0.03663707,-0.05372906,0.00705786,0.0051289294,-0.045253083,0.017589774,0.005376807,0.09180575,-0.012141648,-0.00084591797,0.0017322085,0.07544814,-0.022769596,0.016343612,-0.025745789,-0.030382453,-0.08929164,-0.013421412,-0.052005775,0.013303583,0.013106229,0.0067280126,0.037606135,-0.03506165,-0.13051069,-0.00093880336,-0.06610962,0.043312185,-0.033310633,-0.051614646,-0.0013092151,-0.018798102,-0.06102531,-0.0066544805,-0.05707755,0.0070361183,-0.03549953,-0.026831985,-0.10853285,-0.024352454,-0.013266889,0.070919834,0.025521977,-0.035510506,0.019002296,-0.020633796,0.014656702,-0.0029194304,0.06823546,0.02713845,-0.059972066,0.030056253,-0.05291767,0.04806656,-0.062350146,-0.030702097,-0.002096773,-0.11314848,-0.04215315,-0.0138559975,0.041188132,0.05192669,0.0550804,-0.007060361,-0.019928288,0.11248652,0.0017150013,0.0037370252,-0.060798768,0.020991204,0.024765708,-0.030636538,-0.044931527,0.108606786,0.015061473,0.022563118,0.020833215,0.028456304,-0.007571253,-0.062174473,0.022570936,0.046021327,0.043102667,0.049302574,-0.026192004,0.11154125,-0.081082016,-0.05033025,0.06389281,0.08895748,-0.0771092,0.008167805,0.009791957,0.019083811,0.015639644,0.039425034,-0.0043519586,0.0017190393,0.039558034,0.03023442,0.011168998,-0.035305228,0.019608686,-0.038956597,-0.111486524,-0.028357126,0.011843024,0.03640303,-0.02259138,0.08828359,0.08696006,-0.019011516,0.07124899,-0.095083125,-9.3811475e-34,0.114056334,0.025701752,0.0070633953,-0.012091207,0.034516666,0.024390506,-0.07697795,-0.004888289,-0.018178776,-0.06628953,-0.08794139,-0.09490181,0.03285066,0.12088039,0.04983604,-0.009450933,0.026556488,-0.02380502,0.04084927,0.04443094,-0.006857309,0.044299692,-0.041858148,-0.028138254,0.042382654,0.07655775,-0.06898875,0.022712255,0.08700405,0.012840486,0.051536802,-0.053909175,-0.072283484,0.11373853,0.027390538,0.062395547,-0.027060354,-0.025116436,0.050634127,-0.009585125,0.09483889,0.03339959,0.053794317,-0.040414263,0.046360757,0.038662855,-0.037529055,0.006125206,0.026159616,0.02809975,0.04046357,-0.011291906,-0.018549003,0.0016986,0.028870974,0.033002958,0.00752362,-0.01597026,0.025514312,0.0727813,-0.06830712,0.14611337,0.01698401,-0.004368157,-0.0074672834,0.051532302,-0.034367513,-0.034966648,-0.10140696,0.022089675,0.0034496505,-0.106123865,0.10367907,0.028491238,-0.032325134,-0.049088586,0.008805449,0.031210065,0.010928059,-0.057138056,0.020846318,0.062426064,-0.030874716,-0.021040669,-0.03361057,-0.032603286,-0.06707342,0.0575372,-0.02228507,0.06676736,-0.0009111538,0.035658315,-0.011898203,-0.020111807,-0.08936183,-1.4663618e-33,0.09843209,-0.08553459,0.014445576,0.00040407263,-0.07293738,0.010482745,0.035566404,-0.071129374,0.068861954,-0.012409843,0.10670013,-0.040685803,0.04607574,-0.07457611,-0.021399545,-0.0034050061,-0.10528135,0.048458427,-0.038059134,-0.013887576,0.00762871,0.09697635,0.03155182,0.032045163,0.05974055,-0.07286489,0.0055296924,0.13449112,0.0027968592,-0.06845282,0.012037224,-0.038982294,-0.022672951,-0.05144902,-0.066084735,0.027816018,-0.027985647,0.020333026,-0.013177698,-0.009083596,0.012923309,0.021257743,0.010552607,0.03617273,0.06968891,0.06711329,-0.03872518,-0.050882682,-0.013582573,0.01796,0.05529148,-0.025085898,0.018101532,-0.010708195,-0.04415122,0.06944053,0.019209199,0.038577847,-0.04361558,0.0017601886,-0.009598085,-0.034329154,0.11366468,-0.010243471,0.00804064,0.009792225,-0.032341883,0.03946699,0.05534799,0.007476123,0.077709086,-0.01259947,-0.0018845965,0.066776484,0.0440002,0.038072363,-0.12617958,0.0024795462,0.052403778,-0.09617553,-0.00061303354,0.08580526,0.017860401,-0.013315703,-0.010542139,-0.046444625,0.037334178,0.086405896,-0.022203494,-0.0118025765,-0.044708736,-0.012293006,-0.016422356,0.026495034,0.03180373,-3.8943536e-08,0.008405098,-0.048334505,0.07629026,-0.07630521,0.029827187,0.0063844253,0.03215392,0.019127285,0.07140473,-0.017843232,-0.0737605,0.09666361,-0.035152834,-0.021741457,-0.020526214,-0.010880054,-0.03581333,0.061953552,-0.0324558,-0.0060214526,-0.118578345,0.045866385,-0.13857153,0.049214616,0.017744083,-0.055711675,0.09068938,0.03230848,-0.04872387,-0.036340255,-0.0024221654,0.06691581,0.0129179135,-0.043372862,-0.07747696,-0.029028058,-0.0016836528,-0.021051379,0.00588891,0.071763635,0.0063521783,-0.051727053,0.004562025,-0.05486546,-0.052754387,-0.018545672,0.033354413,-0.075631395,0.02813636,0.017036835,0.071752764,0.020860694,-0.055883966,-0.12423178,-0.024839522,0.020204825,-0.06054152,0.002812774,0.032774843,0.004427977,-0.007815426,-0.039223555,0.15703414,0.003253886 +2.4.2.1,"Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase.",384,1.0,0.021709463,-0.001046052,-0.041284442,-0.008658679,0.03206044,0.037602637,-0.13167553,0.024137465,0.036677346,-0.0025107458,-0.022033256,-0.016525874,-0.096551776,0.05700373,-0.030224945,0.015064703,-0.072253644,0.051092267,0.0014429874,-0.003245068,0.054915577,0.010903378,-0.010700255,0.014468019,0.023843525,-0.042784143,0.044809274,-0.027938623,-0.019005854,-0.067243055,-0.0035668816,-0.007336294,0.023613393,-0.07432788,0.082524456,0.049001195,-0.058050055,-0.0400344,0.058839884,0.013289935,-0.0044690296,-0.009270276,0.03694409,-0.022375427,0.017990703,-0.004765891,0.012842792,0.046631925,-0.04311182,-0.020904819,0.037967965,-0.047132704,-0.05196349,-0.12742446,0.075978845,0.016017076,-0.042529915,-0.060371168,0.037518565,0.0197983,0.024015121,-0.03397909,-0.027592586,-0.0028136708,0.03263917,0.021607451,0.07364814,-0.05858768,0.046918202,-0.053308964,-0.018161604,-0.08632813,-0.01777852,0.069032356,0.061377175,-0.03156203,0.06255629,0.0032641126,0.032619342,-0.026656076,-0.057408787,-0.004010911,0.0023597314,-0.06275803,0.036618467,0.06895551,-0.02885381,0.03763405,0.01708617,0.069321156,0.0044160387,-0.031289488,0.09064918,-0.07652398,0.054590996,0.06287643,0.014208424,0.089486286,0.059836973,-0.08665898,0.060134687,0.103784025,-0.11644247,-0.06250052,0.055875026,0.061767656,0.06258423,0.032878146,-0.030775627,0.0019481329,0.008645877,-0.043759547,0.0024212715,-0.068594255,-0.01777319,0.06886322,0.01365502,-0.076311484,-0.04099639,-0.005787037,0.041267574,-0.059401568,0.070713066,0.07795043,-0.04489503,0.099486396,-0.07678034,4.462586e-33,0.027802955,0.02148876,0.016210021,0.029589897,-0.0248117,0.031550933,-0.09167584,-0.004406255,-0.014493262,-0.038374666,-0.15317342,-0.069260634,0.038499374,-0.031379655,0.014548171,-0.021336777,0.046007432,0.015985126,-0.021917135,0.020526387,-0.0011250785,0.051193126,0.012009116,0.038503986,0.018656766,0.035445698,0.0069965236,-0.032831483,0.07435092,-0.048167348,-0.05766475,-0.057948887,-0.045473777,0.03937361,-0.009784302,-0.016704919,-0.08049951,-0.012267244,0.069688864,0.08938048,0.053154547,0.05541075,-0.026861338,-0.041201144,0.040473238,0.0047881138,0.018174782,0.022882508,-0.03533389,0.01886433,0.012235574,0.0014368976,0.07369714,-0.057514783,0.06948483,-0.016815053,-0.016616086,0.0034309267,0.070366725,0.06718109,0.0050572227,0.057212453,0.0094072865,-0.051395148,-0.069083564,0.03981157,-0.06517402,-0.04820436,-0.024252016,0.020525452,0.0018307049,0.014880812,0.118662246,-0.03207618,0.07943487,-0.049615372,-0.0719264,-0.03987667,0.023088459,0.060258448,-0.031307433,0.08320411,0.048921898,0.0002910729,-0.0020783283,-0.0148735205,-0.0072356737,-0.057779294,0.015893476,0.099038504,-0.043737482,-0.049394723,-0.101158895,0.015386356,0.042771287,-4.65285e-33,0.03118377,-0.06961671,-0.06008388,-0.096500486,-0.08525787,0.016635954,-0.04494961,-0.16267587,0.06854189,-0.009303685,0.07776431,-0.054994646,0.06369487,-0.106877156,-0.01565159,-0.005941343,-0.050857957,0.0713953,0.0016047672,0.0714133,0.0176524,0.00032317272,-0.052040234,0.026987605,0.09139298,0.024301998,-0.03265228,0.00786295,0.09650684,-0.0165595,-0.07176751,-0.007309051,-0.026684871,0.017320901,-0.030310407,0.068394884,-0.02229531,0.0629912,0.028926833,0.010863833,-0.018625088,0.110249236,-0.0016356637,0.060268965,0.0095673455,0.05813413,-0.015722245,0.015644843,-0.024935987,-0.06677461,0.072376154,-0.018695334,-0.023249194,0.06769961,0.00012499817,0.063152656,0.0032169973,0.021996727,0.025073452,-0.0058690053,-0.0630455,-0.08748173,0.020167714,-0.04743889,0.04482562,0.07052496,-0.10640253,0.03104307,-0.037747692,-0.023624143,0.07089183,-0.03632529,-0.06928498,-0.0016040008,0.02244315,-0.06455563,-0.054753534,-0.08079099,-0.020410102,-0.05914693,-0.011610483,0.037717823,0.034906764,-0.04142418,0.036588646,-0.05526023,0.05067942,0.067706265,-0.048585888,0.031364672,-0.003606693,-0.03347791,-0.01874058,0.054298624,0.039127257,-3.211436e-08,0.002281017,-0.023850495,0.028554404,-0.06337886,0.031633943,0.051372513,-0.01062694,-0.019321663,0.026844993,-0.009204462,-0.051132347,0.029816004,0.038402263,-0.05271033,0.09824592,0.029754393,-0.03183049,-0.021684414,-0.017700115,0.008328331,0.023712996,0.044537522,-0.12186026,0.013001782,-0.07713755,-0.04192065,0.036329996,0.01532484,0.015626643,-0.0843677,0.0048924363,0.031658556,0.02382135,-0.0870746,0.03838812,0.025111811,0.069983155,-0.00698065,-0.0006111361,0.030177848,-0.085176535,-0.06959685,-0.08796503,0.049233265,-0.030322313,-0.012787894,-0.00048689885,-0.008284987,-0.007611288,0.051813852,0.098042,-0.016969727,0.025577767,-0.070035614,-0.034577798,-0.0050939675,-0.019988775,-0.07671829,0.05608709,-0.031742766,0.09164367,-0.029093847,0.17935982,-0.026921725 +2.4.2.2,"Unlike EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase, this enzyme can accept both the ribonucleosides uridine and cytidine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine [3,6]. The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction.",384,1.0,-0.00980982,-0.024277601,-0.023666805,-0.093152024,0.037634246,0.0010034011,-0.085205145,-0.015575141,0.047757443,0.07402202,0.025047576,0.044066146,-0.034420043,0.084293075,-0.040341605,-0.030299917,-0.088170104,0.021717096,0.04740713,-0.05296306,0.04212027,0.02200551,-0.017118005,-0.0045109265,0.035499644,-0.02321503,0.05820219,0.025096927,-0.08702438,-0.07041787,-0.00028587523,-0.13461533,-0.00043674622,-0.01787774,0.03975556,0.0420427,-0.051184207,-0.059389565,0.01971928,0.045881607,0.010503941,0.012622917,-0.020910533,-0.030530782,-0.036824018,-0.03379469,-0.050805636,0.0408363,0.023751972,0.021115683,-0.015905576,0.016447643,-0.023193255,-0.03778124,0.028290829,0.080960855,-0.07204803,0.015782347,-0.030905843,0.03280892,0.013744876,-0.04185838,0.02888231,0.006757383,0.018227406,-0.0114646545,0.029554745,-0.072511554,0.011735056,-0.090872474,-0.0499652,-0.09078631,-0.009176753,0.02149847,0.031612236,-0.010709309,-0.025904968,-0.028847542,0.004824526,-0.036480222,-0.010169742,-0.10722874,0.004467344,-0.009143194,-0.0247283,0.046658088,-0.04555233,-0.007549128,0.076816015,0.008829936,0.08063113,-0.015941802,0.049618173,-0.040240187,0.071094565,0.04140245,0.0100236,0.101590216,-0.04233351,-0.080199435,0.015362468,0.067969635,-0.08677228,-0.07933845,0.038334653,0.04077028,0.07021304,0.04239021,-0.04430701,-0.02181804,0.006161963,-0.005824457,0.04181967,-0.00808887,-0.033918463,0.0863717,0.0354808,-0.04295447,-0.010342374,-0.07433312,0.049050283,-0.06718294,0.074897595,0.04456679,-0.04513713,0.07249888,-0.07790044,3.0738156e-33,0.04150453,0.09558607,0.019708076,-0.016840188,-0.027880581,0.05250182,-0.05715601,0.03954313,-0.056887563,-0.120256744,-0.15430515,-0.052086834,0.045347065,-0.02379847,-0.0476039,-0.07569612,-0.026096722,0.08132701,0.051991403,0.035234775,0.08785355,0.09831008,0.030240206,0.054120492,0.039058503,0.013778647,-0.023782104,-0.00065011065,0.046482425,-0.011334564,-0.023072632,-0.03601937,-0.09197974,0.03606635,-0.020999055,-0.040511314,-0.10978324,0.0045289225,0.064956255,0.029822994,-0.05038037,0.012287806,0.027023314,-0.053866025,0.013910442,-0.057399027,0.014115875,0.034620747,-0.06503765,0.043520465,-0.019618558,0.020637695,0.06227108,-0.060276255,0.021307409,-0.040758748,0.027873132,-0.007815166,0.09808428,0.03860002,0.047146488,0.09836626,-0.009862169,-0.010702251,0.0059469487,-0.007726465,-0.1032686,-0.08562826,-0.0064297095,0.08003944,0.022875931,-0.011070112,0.05502099,-0.032076944,0.06441617,-0.05967751,-0.07382998,0.03570984,0.0033156862,-0.0036276837,0.0012369484,0.013045415,-0.003210899,0.05160659,0.019863365,-0.0354986,-0.010037105,-0.03370558,0.014407958,0.06701194,-0.013722093,-0.018707963,-0.103414096,0.022877337,0.07201766,-3.057897e-33,0.13185333,-0.07064735,0.07431789,-0.0059046885,-0.059702948,0.028705625,0.036921732,-0.032738697,0.14069237,-0.019031893,0.092733406,-0.016849166,-0.008125719,-0.111571535,-0.032883678,0.0053050397,0.0092252605,0.044915788,-0.013772014,0.030631399,-0.0046476023,0.053272966,-0.050309483,0.03449264,0.07112735,-0.04058608,0.059960414,-0.00031287747,0.034253698,-0.06083091,-0.03665044,0.0075949747,0.00016066074,0.01160521,0.0032968724,0.048868332,-0.052633867,0.004586296,0.0063762125,-0.02760283,-0.0038640816,0.018513098,-0.0009193361,0.05245312,0.06104883,0.00023552755,-0.029494615,0.0140663115,-0.09606371,-0.035091963,0.0025364303,-0.018742627,0.035377424,0.052446146,0.05355252,0.027453061,0.03750452,0.09469719,-0.030220442,0.015218025,0.0019822277,-0.038810607,0.032716285,-0.012273504,0.036910444,0.0043786652,-0.10215572,0.07293599,0.023730062,0.012044047,0.018176364,-0.07000075,-0.006746694,0.0019458272,0.030962164,-0.056400433,-0.08495093,0.0073097046,0.053150844,-0.030358152,-0.03750776,0.021708336,0.018698674,-0.017383283,0.07038096,-0.019156184,0.06978,0.09269329,-0.08696847,0.025157683,-0.022952383,-0.05057482,-0.023703441,0.05895752,0.1118437,-4.314463e-08,0.03184357,-0.026291292,0.01728828,-0.07429423,0.010354847,-0.015089907,0.028416464,0.03636603,0.009553978,-0.064142056,0.023324654,0.06095566,0.03636097,-0.010345651,0.06755496,0.051714815,-0.10203628,0.038333,0.010897683,0.06980023,0.023804624,0.01278837,-0.18407059,0.011250548,-0.015417701,0.023072552,0.0048801173,-0.04172415,-0.021900594,-0.023309905,0.056643423,-0.06860648,0.036688216,-0.10825123,-0.028629031,-0.013638039,-0.022830324,0.0130237015,0.012149737,-0.0016962192,-0.029181343,-0.058121458,-0.024282657,0.024734098,-0.007139084,-0.0053543523,0.009480317,0.004356709,-0.04296267,0.014702724,0.062140863,-0.015498351,0.00874366,-0.13035496,-0.01705499,0.019085968,-0.010181899,-0.11691772,0.021111485,-0.011051907,0.11380032,0.032888677,0.17924316,0.0032471025 +2.4.2.3,The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. The mammalian enzyme also accepts 2'-deoxyuridine.,384,1.0,0.018556744,-0.015836837,-0.057302546,-0.09169743,0.022519788,0.0058630286,-0.093332574,0.07408689,0.020630788,0.018121032,0.0033787577,0.05608805,-0.07152978,0.094757445,0.0146347815,0.013271945,-0.09564777,0.029694637,0.018405411,-0.07585106,-0.02788894,-0.002864124,0.00091234414,0.024069943,-0.012639674,-0.0060797962,0.05060526,0.035734672,-0.040112793,0.008348787,0.02045818,-0.1522459,0.022835169,0.009975376,0.04396901,0.11461785,-0.08156987,-0.0062453244,0.05769312,0.017069736,0.0072881356,0.017726107,-0.053642605,0.013266069,-0.029701564,-0.024048178,0.0034394213,0.047275145,0.007370555,0.073519446,-0.03820027,0.042069882,-0.05845348,-0.04237906,0.07362706,0.078835875,-0.037680473,-0.0004746435,-0.013811051,0.011704982,-0.0063505275,-0.016005242,-0.026150128,0.0010320458,0.035561487,-0.047808267,0.06169432,0.007614445,0.021264223,-0.041939773,0.008941091,-0.058334503,-0.014587921,0.030562151,0.002103312,-0.029584114,-0.04344452,-0.057898056,0.021700358,-0.0163356,-0.03256293,-0.1004224,0.026685635,0.009861978,0.017347425,0.05922399,-0.046309892,-0.0036545738,0.023156693,0.026466193,0.0519927,-0.025558192,0.010115221,0.014347971,0.00242384,0.046747863,-0.029722996,0.06888944,-0.04742835,-0.06024849,0.018462235,0.008852563,-0.09908418,-0.06766511,0.00011684172,0.0054395245,0.067107275,0.01872313,-0.0030704911,0.008250692,0.025167586,0.095808975,0.005470734,0.04326993,0.024788313,0.13016178,0.044174317,-0.012954115,-0.020928478,-0.002426163,-0.0065325503,0.003893167,0.06505428,0.079236,-0.056840304,0.0070449193,-0.011785066,9.91733e-34,0.013548983,0.012443847,0.038858235,0.033016346,0.012038628,0.057866346,-0.07069144,-0.0019766814,-0.042252436,-0.060836323,-0.13414273,-0.12220767,0.075011075,0.042693004,-0.048093013,-0.08455815,-0.031414542,0.025369331,0.045496125,0.03032049,0.075951286,0.03471371,0.06435806,0.08951962,0.02086779,0.03261848,-0.04230803,0.085326426,0.055904564,-0.021484386,-0.056060255,-0.1277995,-0.0883651,0.03465281,-0.009830394,0.0028633138,-0.08040271,-0.024341848,0.0434521,0.0649127,-0.014859081,-0.06035148,-0.014167994,-0.02492042,0.012515225,-0.02540671,0.019919641,0.08641525,-0.079734065,0.00547581,0.056022808,-0.06470172,0.06482449,-0.048234086,-0.053216606,-0.00273241,0.0072198226,-0.042666804,0.08462346,0.04286144,0.090431534,0.01616918,-0.0036583403,0.0052210824,0.07869383,-0.023079358,-0.032110404,-0.044268146,0.012340371,0.067228526,-0.047728922,-0.04643155,0.019277904,-0.03360225,0.019975144,-0.024718031,-0.08826035,0.0491998,0.018145962,-0.020876518,-0.050909042,-0.016437223,-0.010037051,0.029032053,0.008592188,-0.0153544415,0.019477189,-0.10145152,0.04998531,0.026981363,0.01961177,-0.058235098,-0.08591791,0.009726031,0.07435766,-1.4520008e-33,0.10776077,-0.09945346,0.038478643,-0.07082666,-0.09349156,0.0027937302,0.043778714,-0.046320926,0.057559203,-0.07432545,0.027876947,-0.02167048,-0.013922255,-0.07591969,-0.06621038,0.009664045,-0.0051143966,0.06906379,0.035747763,-0.017851148,-0.018895423,0.06020515,-0.037257574,0.03610726,0.020649884,-0.011296948,0.034396682,-0.033674356,0.07657303,-0.02982802,-0.04559402,-0.00016821442,-0.043184493,0.02299698,0.044755373,0.06928289,-0.05986099,-0.020415924,0.00717707,-0.049397767,0.012953151,0.10696115,-0.026291873,0.07650219,0.0067373356,0.040643867,-0.055285927,-0.052956954,-0.07838146,-0.039215427,0.05554204,-0.022752816,0.04028361,0.03355963,0.099637635,-0.03768284,0.021189645,-0.023701822,0.058532506,-0.033049393,-0.08836193,-0.070268005,-0.014120393,0.049963083,0.0068708537,0.017884362,-0.0738215,0.05473293,0.013310454,-0.0016987573,0.079340935,0.020075165,-0.028657714,0.031464115,-0.09346217,-0.035823848,-0.057291836,0.056971945,0.06302689,-0.020228827,-0.046375513,-0.01076017,-0.006460947,-0.067404084,0.016506357,-0.064642966,0.0127324965,0.13697557,0.0028942595,-0.008407438,0.0066787726,-0.08654947,0.0279973,0.04234072,0.055757083,-2.85041e-08,-0.0460615,0.018590169,0.015690831,-0.043466143,0.012344431,0.014403748,0.0588844,0.061550166,0.01533986,-0.036123972,-0.019229444,0.050768044,0.016957909,-0.03349075,0.0055355546,0.082544275,-0.060383525,0.018613087,0.05132423,0.031707723,-0.04276273,0.028488884,-0.14997514,0.05429391,0.03881019,0.02628145,-0.009880976,0.025863688,0.03946909,-0.046038248,0.047207497,-0.075800285,0.07631564,-0.11503023,-0.0072330288,0.022039093,0.0050914404,0.030015418,0.067617774,0.02058583,-0.046140615,-0.052488245,0.0062767123,-0.038539343,-0.022212284,0.028377801,-0.010002222,0.06726082,-0.051223937,0.04058494,0.095710315,0.009209757,0.026573397,-0.06428284,-0.11216204,0.0018025335,-0.06481524,-0.08595033,-0.018585341,-0.08418669,0.06565199,0.059693083,0.16326107,-0.020332772 +2.4.2.4,"The enzyme in some tissues also catalyses deoxyribosyltransferase reactions of the type catalysed by EC 2.4.2.6, nucleoside deoxyribosyltransferase.",384,1.0,-0.037025075,0.03542041,-0.014784493,-0.016693154,0.04696849,-0.0007712589,-0.10626142,0.064354,0.028421417,0.040312085,0.014778038,-0.046635773,-0.119596064,0.018078882,-0.0056716055,0.035248183,-0.14801621,0.049267266,0.018671595,-0.026976578,0.011909436,0.0042785304,-0.022009984,0.013249123,0.047758505,0.00018526019,0.039675996,-0.039892886,-0.059054982,-0.06814319,0.028907595,-0.07725326,0.0048373523,-0.0763649,0.08611962,0.06810101,-0.065765895,-0.07149976,0.0042221686,-0.0039754575,0.02356142,-0.0034356168,-0.016100425,0.00216574,-0.004454383,-0.017912002,0.031519238,0.0003841808,0.029239146,-0.042854656,0.018212732,-0.022563118,-0.050800443,-0.014356581,0.039671224,0.018106852,-0.06785603,-0.010331294,0.0032517922,0.02547918,0.02258543,-0.022357322,0.018959532,-0.00638921,0.04108004,0.0028376179,0.12857491,-0.055138785,-0.009326608,-0.06411088,-0.06331349,-0.07955813,0.017614925,0.037270885,-0.030534208,-0.015118116,-0.045292452,-0.037102308,0.06190301,0.021103334,-0.009031317,-0.025666095,0.017100258,-0.043124843,0.034779027,0.028476855,-0.028849054,-0.009962152,0.008667577,0.066387974,0.009091911,-0.032371752,0.0133775035,0.0043387422,0.014947347,0.07704536,0.03697158,0.20281947,0.07136905,-0.0521229,0.045981076,0.10265563,-0.1453989,-0.07232622,0.046959605,0.012092762,0.0974627,0.0050412863,-0.00104737,0.05917591,0.008478172,-0.0381222,-0.013621401,0.007878826,-0.045256305,0.096312,0.016074715,-0.014193846,-0.03712891,0.037284452,0.073791,-0.03599403,0.065687194,0.06780379,-0.035538565,0.06746536,-0.032546446,5.632008e-33,0.034811836,0.06627825,-0.022726037,0.038572542,-0.024728796,-0.005239358,-0.09490741,0.0442742,-0.09719017,-0.047577173,-0.12045181,-0.060535334,0.0561981,0.005666687,-0.025658853,-0.051571604,-0.0009154713,-2.8033324e-05,0.018814405,-0.010658869,0.007733714,0.0029992533,-0.004618231,0.09281104,-0.005673608,0.073275685,-0.090420775,0.053150866,0.06390575,-0.011548808,-0.043953307,-0.11677999,-0.026987424,0.018997304,0.028772958,-0.021437136,-0.055582635,-0.0057627996,0.021406455,0.08429046,0.014129297,-0.0013175515,-0.020910768,-0.07857205,0.043385666,-0.010520095,-0.017022418,0.06171544,0.04584642,0.017145125,-0.0010403531,-0.05514228,0.075767204,-0.072913334,0.029058233,-0.038979817,-0.009763849,-0.027038591,0.016490253,0.07722033,0.013786152,0.058924776,0.028837875,-0.06554217,-0.032588344,-0.02033732,-0.069446504,-0.021308802,-0.03271232,0.008915915,-0.007489581,0.0036563436,0.08900262,-0.006472363,0.09236076,-0.01086054,-0.0708859,0.0065209502,-0.015148553,0.008372711,-0.020366319,0.04882886,0.03602621,-0.049672943,0.039869435,-0.02411747,-0.06998946,-0.04034356,0.033426855,0.08914377,-0.04786377,-0.026874186,-0.10515572,-0.04076017,0.041402597,-6.442414e-33,0.03708894,-0.011769132,-0.07889343,-0.100286365,-0.066180184,0.07637198,0.025056636,-0.06404785,0.099822275,0.050648995,0.0553913,-0.084279895,0.07208839,-0.091226324,0.035433497,-0.014279002,-0.039060205,0.039179966,-0.0010651314,0.0074505275,0.02742499,0.024484418,-0.026232205,0.0466504,0.06858754,-0.0010230098,-0.024931146,0.030327165,0.10418854,-0.013448632,-0.11258405,-0.0088911215,-0.012720446,0.05685994,0.0042754496,0.065710574,-0.022964315,0.024536347,-0.011620744,-0.004278087,0.027797071,0.043385927,0.020778999,0.059327167,0.0051005995,0.029697027,-0.050601568,0.033877045,-0.053023983,-0.05638998,0.03106453,0.00545296,-0.059000704,0.0442796,0.0061863554,0.07339768,-0.0015969393,0.021748113,0.024105048,-0.02088704,-0.030666452,-0.10485759,0.033731442,-0.0041997763,-0.005132553,0.05166828,-0.08500546,0.03983617,-0.069262795,0.04114648,0.07705045,0.005731297,-0.088197306,-0.0026432902,-0.04976974,-0.043356,-0.0666091,-0.047283728,0.041948278,-0.09865198,0.01550808,0.0042152596,0.034566697,-0.07673814,0.007651178,-0.040592853,0.062143248,0.097688064,-0.09539562,0.02692985,-0.022845363,-0.05801246,-0.03998595,0.08710528,0.01850595,-3.605103e-08,0.0056037894,-0.09031237,0.03320968,-0.03371761,0.056748733,0.06856921,0.008088589,0.039197467,0.041075766,-0.002200415,-0.010775681,0.044049922,0.03065185,-0.036460668,0.09050256,0.06636184,-0.03499075,0.029297343,-0.024030749,0.008473608,0.030257931,0.009005696,-0.11095089,0.029148906,0.00912363,-0.029297648,0.026447572,0.06990752,-0.017261524,-0.07265509,0.0033186036,0.010353385,-0.0032972095,-0.06713742,-0.03824846,-0.019863613,0.034815773,-0.04649358,-0.034194462,0.030123563,-0.07870126,-0.053609554,-0.06570226,0.022744248,-0.007799388,0.0050899074,0.020175917,0.015097588,-0.003421778,0.033085495,0.081447184,-0.08643933,-0.000552345,-0.065200716,-0.056067098,-0.016472844,-0.005118924,-0.036967654,0.0061093215,-0.025663141,0.04370519,0.048653245,0.20245183,-0.0379576 +2.4.2.5,Base1 and base2 represent various purines and pyrimidines.,384,1.0,0.02349891,-0.07688745,-0.058281086,-0.080247775,0.026513819,0.020012572,0.015704013,0.0961506,-0.019730693,-0.049666993,0.025178436,-0.05450971,-0.03808092,0.033372615,-0.028625293,0.014924132,-0.09816009,0.013831376,0.091256864,0.031396665,0.045604598,0.018286306,-0.06777336,0.041490324,-0.011905817,0.068175554,-0.012505637,0.10209135,0.022172559,-0.06927857,-0.008787738,-0.043201834,0.1144251,0.044267334,0.07278113,-0.0020581805,-0.016661055,0.019687459,-0.004260452,0.06052259,0.035916876,-0.0014393232,0.023604158,0.036890503,-0.028068755,0.058516234,0.029021695,0.03349837,-0.06680558,0.023984915,0.06867613,-0.050650336,-0.07131434,0.09270515,0.059074454,0.040215872,-0.10591066,0.06756438,-0.07944622,0.01310236,-0.04463768,0.017774675,0.024928726,-0.09932289,0.067173526,-0.042682827,0.08040861,-0.018088156,0.0056262873,-0.023916438,-0.0077727577,-0.02369298,0.013827127,0.046815805,-0.03347782,0.02710382,-0.045115612,-0.03540439,-0.002321976,-0.05176624,-0.064821094,-0.0338936,-0.015162478,0.063747905,-0.0051003452,-0.010180588,-0.026006153,0.018566692,-0.04618759,-0.009991745,0.054469522,-0.003914508,0.069633745,-0.011088055,-0.0016803977,0.06043226,-0.00010040227,0.0604346,0.0553238,-0.04075695,-0.0015000147,0.035397053,-0.0882126,0.0041367025,-0.015725741,-0.015810398,-0.006989476,-0.04124954,-0.011439019,-0.063005984,-0.058422014,0.037323363,-0.08389637,0.034482714,0.026548265,0.011703847,0.07068011,-0.015340887,-0.0018370949,-0.020939512,0.037871275,-0.043030545,0.0329481,0.064503655,-0.08831368,-0.07789115,-0.00028272736,4.680353e-34,0.007985989,0.06947131,0.037743397,0.04497306,-0.002710168,0.032955565,-0.06073167,-0.0051153847,-0.015737157,0.01970461,-0.09704288,0.0026286067,0.068125606,0.03562442,-0.012833632,-0.098414995,-0.010593846,0.0585739,0.073035285,-0.053073946,0.005715959,0.1800412,-0.047666363,-0.030796068,0.024942711,0.022301313,-0.058967944,0.0053292005,0.020848073,-0.056290466,0.009797527,0.014686456,-0.05289679,-0.006230175,-0.04162919,-0.034649238,-0.017158037,-0.04261747,-0.00612999,0.007949971,0.038609024,-0.020316381,0.020818042,0.030138709,0.055956297,-0.04407326,-0.13959154,-0.014188941,0.07808054,0.00095743814,-0.004966219,0.0013824872,0.06669226,-0.013401545,-0.026702566,-0.0088420035,-0.028917903,0.021714756,-0.038019318,0.057462305,0.03666364,0.06333846,0.013395531,-0.0025377455,-0.017909484,0.017915096,-0.11303355,-0.066453345,0.051745612,0.11811589,-0.06029793,-0.012913893,0.08794009,-6.895099e-05,0.008116025,0.010246246,-0.051600374,0.09177539,-0.06822022,0.025568845,-0.084351465,-0.017669521,0.016960314,0.010431026,-0.08239981,-0.018619878,0.028622046,-0.08790636,0.030461492,0.051172446,0.04845312,-0.010462469,-0.02671704,-0.04128167,0.026319338,-2.1871094e-33,0.011477581,-0.014715503,-0.03345297,-0.054503657,-0.08837592,0.072019644,0.086372904,-0.08891747,-0.022080952,0.0448888,0.03986244,-0.012326333,-0.08501367,-0.090402715,-0.0674387,-0.057016395,-0.015179285,0.032638226,0.011513521,-0.006770803,-0.061253533,0.04371514,-0.09456007,0.09038224,0.034281887,0.07373265,0.02660355,-0.0074358257,0.081262656,0.015541331,-0.05285308,-0.02286455,0.042778052,0.015162726,0.019338254,-0.02830142,-0.09089385,-0.03764283,-0.03813554,-0.027802175,-0.01844494,0.04556372,0.031199006,0.01609348,0.029849209,0.04563498,0.0705914,0.03323972,-0.032206282,-0.06454081,0.010484236,0.0058797076,-0.034349017,-0.02525528,0.0921158,-0.012942179,-0.08806859,-0.044563077,0.050533216,-0.0041521303,0.039521616,-0.07701997,-0.03722184,0.011444543,-0.042426173,-0.05511948,-0.07086715,0.014144798,0.020418663,0.03412524,-0.014009231,0.031290624,0.119996555,0.07534375,-0.052125458,-0.060266472,-0.03797222,-0.028900951,0.016693346,-0.05904217,-0.084844425,-0.025667656,-0.04857986,-0.01968799,0.007051263,-0.024847621,0.027166119,0.0779517,0.027101476,-0.02119836,-0.0012142569,0.019020883,-0.032851208,0.06971548,0.01666948,-2.0828638e-08,0.07396819,-0.04277267,0.02897797,-0.020442681,-0.026215276,-0.017517569,0.010121934,0.013694727,0.01693921,-0.013294829,-0.044294663,0.045054372,0.060384005,-0.061666556,0.08122983,0.11183528,-0.044683114,-0.04393345,0.0076805,0.042228535,-0.11249369,0.045862023,-0.12284724,-0.06659484,-0.0134716015,0.04930923,-0.020070106,0.14432347,0.03328771,0.0045684422,0.121967055,-0.025018299,0.05925986,-0.076452516,0.07351099,0.093310066,0.027963031,-0.002254449,0.010385591,-0.026846407,-0.011297744,-0.0845162,-0.073695734,0.03399194,0.056069236,-0.013465181,-0.0334292,0.07810459,-0.043635957,-0.052930858,0.004691456,0.042239804,-0.031505045,-0.015282018,-0.043899436,0.014739326,-0.04659868,-0.09226963,-0.02158103,-0.04851571,-0.003260397,0.05684036,0.106950365,0.033449247 +2.4.2.6,Base1 and base2 represent various purines and pyrimidines.,384,1.0,0.02349891,-0.07688745,-0.058281086,-0.080247775,0.026513819,0.020012572,0.015704013,0.0961506,-0.019730693,-0.049666993,0.025178436,-0.05450971,-0.03808092,0.033372615,-0.028625293,0.014924132,-0.09816009,0.013831376,0.091256864,0.031396665,0.045604598,0.018286306,-0.06777336,0.041490324,-0.011905817,0.068175554,-0.012505637,0.10209135,0.022172559,-0.06927857,-0.008787738,-0.043201834,0.1144251,0.044267334,0.07278113,-0.0020581805,-0.016661055,0.019687459,-0.004260452,0.06052259,0.035916876,-0.0014393232,0.023604158,0.036890503,-0.028068755,0.058516234,0.029021695,0.03349837,-0.06680558,0.023984915,0.06867613,-0.050650336,-0.07131434,0.09270515,0.059074454,0.040215872,-0.10591066,0.06756438,-0.07944622,0.01310236,-0.04463768,0.017774675,0.024928726,-0.09932289,0.067173526,-0.042682827,0.08040861,-0.018088156,0.0056262873,-0.023916438,-0.0077727577,-0.02369298,0.013827127,0.046815805,-0.03347782,0.02710382,-0.045115612,-0.03540439,-0.002321976,-0.05176624,-0.064821094,-0.0338936,-0.015162478,0.063747905,-0.0051003452,-0.010180588,-0.026006153,0.018566692,-0.04618759,-0.009991745,0.054469522,-0.003914508,0.069633745,-0.011088055,-0.0016803977,0.06043226,-0.00010040227,0.0604346,0.0553238,-0.04075695,-0.0015000147,0.035397053,-0.0882126,0.0041367025,-0.015725741,-0.015810398,-0.006989476,-0.04124954,-0.011439019,-0.063005984,-0.058422014,0.037323363,-0.08389637,0.034482714,0.026548265,0.011703847,0.07068011,-0.015340887,-0.0018370949,-0.020939512,0.037871275,-0.043030545,0.0329481,0.064503655,-0.08831368,-0.07789115,-0.00028272736,4.680353e-34,0.007985989,0.06947131,0.037743397,0.04497306,-0.002710168,0.032955565,-0.06073167,-0.0051153847,-0.015737157,0.01970461,-0.09704288,0.0026286067,0.068125606,0.03562442,-0.012833632,-0.098414995,-0.010593846,0.0585739,0.073035285,-0.053073946,0.005715959,0.1800412,-0.047666363,-0.030796068,0.024942711,0.022301313,-0.058967944,0.0053292005,0.020848073,-0.056290466,0.009797527,0.014686456,-0.05289679,-0.006230175,-0.04162919,-0.034649238,-0.017158037,-0.04261747,-0.00612999,0.007949971,0.038609024,-0.020316381,0.020818042,0.030138709,0.055956297,-0.04407326,-0.13959154,-0.014188941,0.07808054,0.00095743814,-0.004966219,0.0013824872,0.06669226,-0.013401545,-0.026702566,-0.0088420035,-0.028917903,0.021714756,-0.038019318,0.057462305,0.03666364,0.06333846,0.013395531,-0.0025377455,-0.017909484,0.017915096,-0.11303355,-0.066453345,0.051745612,0.11811589,-0.06029793,-0.012913893,0.08794009,-6.895099e-05,0.008116025,0.010246246,-0.051600374,0.09177539,-0.06822022,0.025568845,-0.084351465,-0.017669521,0.016960314,0.010431026,-0.08239981,-0.018619878,0.028622046,-0.08790636,0.030461492,0.051172446,0.04845312,-0.010462469,-0.02671704,-0.04128167,0.026319338,-2.1871094e-33,0.011477581,-0.014715503,-0.03345297,-0.054503657,-0.08837592,0.072019644,0.086372904,-0.08891747,-0.022080952,0.0448888,0.03986244,-0.012326333,-0.08501367,-0.090402715,-0.0674387,-0.057016395,-0.015179285,0.032638226,0.011513521,-0.006770803,-0.061253533,0.04371514,-0.09456007,0.09038224,0.034281887,0.07373265,0.02660355,-0.0074358257,0.081262656,0.015541331,-0.05285308,-0.02286455,0.042778052,0.015162726,0.019338254,-0.02830142,-0.09089385,-0.03764283,-0.03813554,-0.027802175,-0.01844494,0.04556372,0.031199006,0.01609348,0.029849209,0.04563498,0.0705914,0.03323972,-0.032206282,-0.06454081,0.010484236,0.0058797076,-0.034349017,-0.02525528,0.0921158,-0.012942179,-0.08806859,-0.044563077,0.050533216,-0.0041521303,0.039521616,-0.07701997,-0.03722184,0.011444543,-0.042426173,-0.05511948,-0.07086715,0.014144798,0.020418663,0.03412524,-0.014009231,0.031290624,0.119996555,0.07534375,-0.052125458,-0.060266472,-0.03797222,-0.028900951,0.016693346,-0.05904217,-0.084844425,-0.025667656,-0.04857986,-0.01968799,0.007051263,-0.024847621,0.027166119,0.0779517,0.027101476,-0.02119836,-0.0012142569,0.019020883,-0.032851208,0.06971548,0.01666948,-2.0828638e-08,0.07396819,-0.04277267,0.02897797,-0.020442681,-0.026215276,-0.017517569,0.010121934,0.013694727,0.01693921,-0.013294829,-0.044294663,0.045054372,0.060384005,-0.061666556,0.08122983,0.11183528,-0.044683114,-0.04393345,0.0076805,0.042228535,-0.11249369,0.045862023,-0.12284724,-0.06659484,-0.0134716015,0.04930923,-0.020070106,0.14432347,0.03328771,0.0045684422,0.121967055,-0.025018299,0.05925986,-0.076452516,0.07351099,0.093310066,0.027963031,-0.002254449,0.010385591,-0.026846407,-0.011297744,-0.0845162,-0.073695734,0.03399194,0.056069236,-0.013465181,-0.0334292,0.07810459,-0.043635957,-0.052930858,0.004691456,0.042239804,-0.031505045,-0.015282018,-0.043899436,0.014739326,-0.04659868,-0.09226963,-0.02158103,-0.04851571,-0.003260397,0.05684036,0.106950365,0.033449247 +2.4.2.7,5-Amino-4-imidazolecarboxamide can replace adenine. ,384,0.99999994,0.07141961,-0.020152774,0.035815783,-0.06195585,-0.020240773,-0.034037534,0.028595231,-0.011988599,0.07357557,0.09409577,-0.008213126,0.023430485,-0.06509692,0.10526098,-0.05024025,0.06993915,0.010879174,0.028778782,0.008108726,-0.063502744,-0.030473137,0.09963545,0.035108566,0.014727647,-0.040380556,0.0472565,0.025278311,0.044756647,-0.041254852,-0.08609996,0.026922805,-0.07967371,0.019015616,-0.0071816556,0.028414812,0.0848161,-0.09181212,0.0016478422,0.034949783,0.00058394345,0.033708222,-0.018908415,-0.029048102,-0.007608259,-0.0370648,-0.04804688,-0.016734667,-0.023658007,0.111609966,0.082253836,0.048482213,-0.09913307,-0.0385206,-0.040043376,0.035226375,-0.019518677,-0.11802451,0.024453312,0.0056721484,0.009797191,0.051850498,0.033382673,0.045554675,-0.010935343,0.012182347,0.03057244,0.0061603915,-0.04308044,-0.04150158,0.010973389,-0.03733816,-0.09450708,0.113398366,-0.005916876,-0.03818525,-0.050878536,-0.009067909,-0.055630226,0.030143041,0.03665801,-0.027981328,0.02285068,0.035154417,-0.013486887,0.09640431,0.041164093,0.037076987,-0.0074355365,-0.00095255504,-0.059763737,0.0009193902,0.010818714,0.0921368,0.0061657857,-0.033598073,-0.06883079,-0.033141416,0.0199982,-0.0238263,0.004939784,0.021548606,0.052764323,-0.112797074,-0.059278544,-0.069469534,-0.006961368,-0.006029457,0.02766078,-0.044745024,-0.01479931,-0.10331254,0.040677447,-0.017054152,0.018150376,0.040393848,0.051087406,-0.01239494,0.022817526,-0.008532341,0.01577686,-0.06785515,-0.06710832,0.05003322,0.020335758,-0.02738794,0.04752703,-0.017252732,1.2784348e-33,0.035299864,0.027150251,0.07307321,0.041252263,0.07318833,0.010474611,-0.027539555,0.0025684233,0.048492696,-0.05051227,-0.102061,-0.031306352,0.051966142,-0.09838645,0.010778292,-0.035822287,-0.14460671,0.0345088,0.06070749,-0.010881567,-0.06398858,0.027968053,-0.023743661,0.046780765,-0.022781733,0.040976275,0.00681285,0.056203548,0.110668115,-0.005369758,-0.08534696,0.009313568,-0.10522293,-0.059272856,-0.10628327,-0.03398804,-0.01689384,0.01526701,0.034604404,0.110278085,-0.04352679,-0.0076143052,0.016148144,-0.054854568,0.08256198,-0.031372145,0.035625104,0.0972334,-0.027272312,0.020721935,0.02673575,-0.07651366,0.054808225,-0.017082378,-0.07349572,-0.014114157,-0.08710296,0.03864942,0.046470694,0.057914834,0.06842966,-0.00018653624,0.025057267,-0.048042588,-0.031943742,0.028566841,-0.040774778,-0.105857424,-0.027830636,0.08524433,0.040037923,0.012925825,0.036680833,0.10153669,0.03157307,-0.052892365,-0.059048247,0.05831429,-0.013743014,-0.0034364334,-0.0007354818,0.014179652,0.0019669002,0.021505253,0.058209516,-0.013877881,0.046019834,-0.022221057,-0.002982941,0.058656495,0.07041447,-0.11749397,-0.08244722,-0.05803443,0.012663553,-1.4764034e-33,0.11202178,-0.062931746,0.00101094,0.032173704,-0.0008948338,0.0040952135,0.038843974,-0.031895008,0.040384,-0.020565877,0.050403066,0.03146957,0.03899387,-0.0271626,-0.026684612,-0.03513269,-0.044058025,-0.06594036,-0.018011406,0.0027527243,0.04703332,0.026689528,-0.0056097526,-0.024182575,0.02959182,0.033554725,-0.007942041,0.028898936,0.07853638,0.011487476,-0.053141948,0.03257104,-0.050199352,-0.006310269,0.004802024,0.06439284,-0.0044566626,-0.064254,-0.12466177,0.012167668,-0.049680557,0.08881219,0.007287217,0.08588527,-0.029916095,0.077931345,-0.041301712,0.026241286,0.008819619,-0.067225374,0.017007302,-0.039780315,-0.009547847,-0.030835766,0.0070669497,0.04933147,-0.0026323742,-0.034030046,-0.0123004215,0.029606182,-0.050938357,-0.049872607,0.08407282,-0.046144325,0.051003333,-0.014286063,-0.018625585,0.018230809,0.045186907,-0.008687988,0.024860684,-0.05953538,0.024364872,0.051788878,-0.012595752,0.013137726,0.032315843,-0.015388923,0.024291687,-0.05210821,-0.040789466,-0.016202394,-0.008468389,-0.05904553,0.027560234,0.07608905,0.06750309,0.06974517,-0.028194727,0.0435152,-0.007487912,0.0044751153,0.005881503,0.059362754,-0.05177573,-2.3136634e-08,0.0800519,-0.10767248,0.023244852,-0.074773565,0.011719881,0.06388389,-0.06961318,0.0511296,0.06908548,-0.0946059,0.011981946,0.08730476,0.012248162,0.12611373,-0.06437835,0.058600888,-0.039666794,-0.01935047,0.014959843,-0.052472223,-0.19752024,0.041790597,-0.090478934,0.010060993,0.078897834,0.042011827,0.061748665,0.044923484,-0.027267441,0.0046098763,-0.010963769,-0.040176038,0.040671308,-0.05574307,0.01416136,0.013686271,-0.058812257,0.05923938,-0.088992804,0.0061811465,0.028539807,-0.03343898,-0.04841391,0.011796836,0.027939724,-0.024336826,0.0015921355,0.0039144363,-0.066101216,-0.038013224,0.034285776,0.003160608,-0.041071802,-0.004960874,-0.020737812,-0.046683557,-0.04016388,-0.098745495,0.039078653,-0.03853656,-0.04205895,-0.001000559,0.11578534,0.010535949 +2.4.2.8,Guanine and purine-6-thiol can replace hypoxanthine. ,384,0.99999994,-0.017755862,-0.011177519,-0.01614536,-0.016706103,-0.018578034,0.032430217,0.0094565,0.050962787,-0.05090518,-0.038390204,0.0043080742,-0.00052018056,-0.065979965,-0.019807102,0.005484757,0.021931257,0.0068100477,0.04966886,0.08924721,-0.040270347,-0.026787087,0.011912851,-0.025947724,0.040880065,0.014882421,0.04090247,-0.0639421,0.09103536,-0.010236769,-0.075523116,-0.07790737,0.004386456,0.010340161,0.051804956,-0.027148101,0.11158946,-0.1215352,0.03749415,0.010561293,0.03178205,0.041697286,-0.010508685,-0.11619369,0.058060825,0.0062917513,0.0009376067,-0.0069148107,-0.021360781,0.004196945,0.07768091,0.03559238,-0.02244553,0.045357205,0.043889355,0.0018723614,-0.04147645,-0.08654172,0.04279691,0.045547448,0.042188037,-0.04083625,0.044277657,0.017193392,-0.025811087,0.035697933,0.007351254,-0.019336857,0.03827454,0.05277362,0.003041884,0.032111764,-0.05156044,0.038831558,-0.0061038304,-0.10938222,0.03195019,-0.030479785,-0.09619562,0.059444427,0.104200065,0.05201913,0.0475893,-0.0119933365,0.06269116,0.08847962,-0.018332116,0.007491851,-0.049472563,-0.10911251,-0.052875668,0.0640115,0.025803821,0.018514168,-0.039943956,0.0026543983,0.013475947,-0.058553018,0.004772992,0.020254288,-0.024920434,0.015872179,0.01610218,-0.07693541,-0.07420433,0.02759336,0.04452647,0.034164324,-0.043599036,0.0536722,-0.0118433675,-0.11708961,0.03016967,-0.024315057,0.061727352,0.0061049545,0.119982794,0.011603319,0.05188743,-0.058142137,-0.007826337,0.008359172,0.008743029,-0.02547776,-0.102380775,-0.03372035,-0.039953563,0.009781995,2.1432138e-33,0.08105212,0.06349697,-0.015570096,-0.0068559633,0.06529364,0.06455267,-0.063531734,0.005120918,0.07275756,0.012917653,-0.083408736,-0.07267509,-0.03973566,-0.01637012,-0.046759233,-0.087873735,-0.08458024,0.018243391,0.12522604,-0.10648135,-0.038556654,0.017549712,-0.09321651,0.029664585,-0.07170709,0.033872824,0.007339341,0.06400389,0.010797096,-0.030060742,-0.0026258805,-0.019277802,0.03794535,0.020398099,-0.109120704,-0.051188182,-0.06639559,0.013460966,-0.018319521,0.02471691,0.0055516623,0.0635115,-0.033541963,0.0139405355,0.07712385,-0.058611203,-0.08323946,0.006150561,0.047996342,-0.00069152174,0.009310816,-0.054992743,-0.013912084,-0.043087594,-0.019929582,-0.019295547,-0.026328387,0.019524354,0.023962073,0.042195916,0.026653847,0.034356937,0.037472483,-0.022820346,0.066890046,0.06176911,-0.10302841,-0.046245296,-0.107506014,0.06055818,0.009183638,-0.046405017,-0.012888364,0.017294854,0.0037504728,-0.0024619591,-0.05949308,0.01749712,0.013905857,-0.10377081,0.009616991,0.013901802,0.0415279,0.084826455,0.052282915,-0.04190026,-0.019062726,0.003779405,0.049409125,0.0015766787,0.06651388,-0.040034126,-0.026222697,-0.061665777,0.0042054034,-1.5158642e-33,0.009147547,-0.035002626,0.06613662,0.004101296,0.0404639,0.10872683,0.055271454,-0.029328793,0.0027510629,0.059726886,0.043779314,-0.023055196,-0.022030097,-0.044213783,-0.009500039,0.05698856,-0.041731417,0.0040283366,-0.081979595,0.062623,0.010459159,0.028141957,-0.07432734,0.026705021,0.0777686,0.033175875,0.071181536,-0.028806083,0.15787062,0.013259649,-0.04452731,-0.07374859,-0.07589502,-0.003165831,0.058611866,0.037881147,0.009859106,0.03692822,-0.10309003,-0.043665744,-0.03794197,-0.08478724,0.07360749,0.0454543,0.049424697,0.10169796,-0.02780966,-0.13071547,-0.0474015,-0.0077292575,0.05280828,0.023065196,-0.035609238,0.07034972,-0.006229303,0.011645686,-0.064995795,-0.11324803,-0.025496077,-0.03958071,0.011963655,-0.019794319,-0.022129554,-0.06574794,0.020747349,0.051253326,-0.038032915,0.06465593,0.039165355,-0.056639805,0.05938907,-0.026300155,0.035311647,-0.01122355,-0.01822737,-0.03570462,0.00087436667,-0.003228789,0.08422882,-0.020301953,0.034713637,0.07643062,-0.081369236,-0.019294398,0.0113424575,0.0068947426,0.027235886,0.06743757,0.016291108,0.05265853,0.000118490534,0.028536424,-0.07696403,-0.012622816,0.07586386,-2.4876268e-08,-0.019729987,-0.115053885,0.05136154,0.0047331247,-0.0057267933,-0.025658628,0.01787691,0.07139419,-0.010417128,-0.031603023,0.007867602,0.087653555,0.10788634,-0.0736008,-0.002966315,-0.023974149,0.00920579,0.07512027,0.008499157,0.014846438,-0.09500107,0.041565802,-0.06574234,0.008473494,0.026385954,-0.015988948,0.05976864,0.017799428,-0.017863125,0.01079967,0.06942813,0.014110594,-0.009172883,-0.0110283885,0.02557625,0.019936716,0.010885275,-0.005022884,-0.062438484,-0.067683384,-0.04680976,-0.017462382,-0.083040886,0.040594555,0.006490333,-0.114914045,0.0737664,-0.020474873,-0.018076483,0.045611855,0.028059594,0.017507039,0.02769884,-0.03673368,-3.520173e-05,0.0011585384,0.037519645,-0.06878297,-0.07499019,-0.027097749,-0.013209551,-0.0384855,0.16886857,0.024520198 +2.4.2.10,"The enzyme from higher eukaryotes also catalyses the reaction listed as EC 4.1.1.23, orotidine-5'-phosphate decarboxylase.",384,1.0,-0.052538842,0.018177167,-0.032259747,-0.02809804,0.053669002,0.0023361028,-0.09252212,3.727521e-05,0.031553928,0.022973835,0.025771044,-0.13103919,-0.09115148,0.01363897,-0.03966764,-0.0057183933,-0.08527867,0.002873131,-0.041343432,-0.059111256,0.03430188,0.017614042,-0.014836749,0.0027546142,0.004128594,0.027483976,0.045494277,-0.061581824,-0.0036342577,-0.08713789,0.024028528,-0.08335361,0.1177763,-0.038742546,0.012377599,0.076779075,-0.062475927,-0.13674231,0.062765844,0.06253467,0.040626194,0.04099217,0.039991245,-0.054381907,0.0018721091,0.030623542,0.024608232,0.0017826926,0.020351512,-0.014618777,0.016701752,-0.022051275,-0.06412516,-0.06127604,-0.004910636,-0.05077701,-0.0309811,-0.027793862,-0.0093654245,0.024442846,0.06537162,0.0010867045,0.008373521,-0.04757805,-0.0026486975,-0.007109229,0.04256734,-0.08029428,-0.027352646,0.009109859,-0.04904929,-0.086636774,0.01554086,0.024087979,-0.039937176,-0.003155692,-0.009651767,-0.098941654,0.031874646,0.046093978,-0.0133890025,-0.010594045,-0.025504177,-0.022579368,0.020289227,-0.018446025,0.0073501226,0.011429143,0.07176572,0.025615321,0.049825683,-0.047020484,0.018209929,0.05827582,-0.035943966,0.027060783,0.007814802,0.1022131,0.050597113,-0.040858038,0.0020319328,0.051815897,-0.11026152,-0.063282326,-0.024333734,0.039943807,0.072789274,0.08183504,-0.03394369,0.041375704,-0.038558204,-0.083738945,-0.0032280996,0.0053295856,-0.007601854,0.07762546,-0.004199559,-0.044545777,-0.024361098,0.01206789,0.05953317,-0.046648264,0.04435005,0.07152502,-0.07126253,0.054866087,-0.1546245,2.4267153e-34,0.032235615,0.038658544,0.038680032,-0.0059668687,0.01678254,0.047326725,-0.06837207,0.04952951,-0.08552669,-0.05117299,-0.07747183,0.0016433833,0.07914004,-0.01633989,-0.08492271,-0.08090336,-0.027511792,0.03898219,-0.018810552,0.007772459,0.044702776,0.034393188,-0.062467147,0.032229476,-0.0053526345,0.025639525,-0.03590081,-0.043094363,0.069229275,-0.010843827,-0.07257853,-0.13662511,-0.10434157,0.008677476,0.019646535,0.0067693745,0.01023143,-0.045755584,-0.017200788,0.039704356,0.019772962,-0.020461813,-0.020670574,-0.07195152,0.03141838,-0.023701936,-0.02737885,0.06624859,0.036969185,0.009201371,0.00047906555,-0.041352917,0.07406879,-0.0038227597,-0.02845538,0.037601072,-0.066127,-0.0025378335,0.07405019,0.077906065,0.017834341,0.031702,-0.013504186,-0.0010062925,0.045613255,0.043011613,-0.04321787,-0.049320757,0.054435145,0.07885572,-0.060489777,-0.0037255874,0.102384806,0.032218628,0.06540706,-0.020162897,-0.062960714,0.03534966,-0.019478759,0.06590628,-0.04658847,0.021874236,-0.008935793,-0.03625641,0.006578919,0.04898616,-0.03010721,0.0021788576,0.022754848,0.12371256,0.008946423,-0.08788769,-0.049916506,0.009453715,-0.024259232,-1.8775165e-33,0.14065638,-0.11484921,-0.041679718,-0.08173499,-0.053225566,0.044523776,0.029858373,-0.012175576,0.023085942,-0.0060687605,0.093973495,-0.035606578,0.08413917,-0.04455947,0.048028603,0.001671181,0.023543257,0.078182325,-0.0004326899,-0.010658839,0.01822798,0.034304943,0.0014368084,0.02319348,0.041085325,0.0061356802,0.03776668,0.03133756,0.07091029,0.036586344,-0.09870319,0.002728478,-0.039289158,0.033503857,-0.055150755,0.029382462,-0.050691217,-0.0009928354,0.026476271,-0.0037382995,-0.0058191153,0.057333335,0.018930119,0.11017992,0.018214405,0.07793505,-0.0211697,0.097094774,0.038659308,-0.05997623,0.021476367,-0.0315516,-0.016358426,0.0034123599,0.014364042,0.03756473,0.009654414,-0.029179053,-0.0033805275,0.028126918,-0.01255765,-0.07988255,0.08462863,-0.054408118,0.046802487,0.03523119,-0.09063729,0.043486375,0.051906336,-0.02912125,0.07393491,-0.026735883,0.0054838588,0.0050811255,-0.015223807,-0.022836016,-0.08258988,-0.0417091,0.057656884,-0.057504337,-0.02799014,-0.004437416,0.030555602,-0.049634393,0.011815106,-0.08712453,0.04556736,0.10770231,-0.00296923,0.051698774,-0.0815541,-0.092796065,0.0036690454,0.08020762,0.05688633,-2.7983873e-08,0.013801724,-0.0017752883,0.041475207,-0.029448822,-0.013501144,0.12874809,-0.021990873,0.019506529,0.06290524,-0.061927397,0.061714556,0.02402931,0.020457841,0.019411013,0.053824257,0.056388274,-0.079697184,0.018813968,0.04897454,0.0055199857,-0.016453946,0.0035889915,-0.06316424,0.007770753,-0.053816196,0.010537332,0.07782435,0.09271072,-0.037335772,-0.09789148,-0.045756213,0.006032858,0.018299688,-0.048704665,0.03874058,0.0058850953,-0.045353297,-0.033557255,-0.00075642066,0.03166143,-0.0018089464,-0.060198244,-0.07500166,0.00625967,-0.021894727,0.066088386,-0.0046037086,0.047838133,-0.0437455,-0.04047535,0.056069776,-0.00079292397,-0.00058140757,0.0055338633,-0.03524421,-0.0024519116,-0.047849085,-0.11674619,-0.0072087827,0.019120283,0.03734583,0.040704817,0.20572242,-0.019840207 +2.4.2.11,"The enzyme, which is involved in pyridine nucleotide recycling, can form beta-nicotinate D-ribonucleotide and diphosphate from nicotinate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) in the absence of ATP. However, when ATP is available the enzyme hydrolyses it and utilizes the energy to drive the reaction from a products/substrates ratio of 0.67 to a value of 1100 [4]. In addition, the Km values for nicotinate and PRPP decrease by 200-fold when ATP is present.",384,0.99999994,-0.014377667,-0.0062363227,-0.015186704,-0.05935487,-0.038199086,0.036402576,0.038990546,0.011503592,0.05764454,0.07293709,-0.004751968,0.03992914,-0.099832825,0.035880428,-0.017420674,-0.03268757,-0.048901156,0.088704914,0.04797503,0.002618642,0.09759449,0.013798831,-0.018042726,-0.028841004,0.029622005,0.050450787,0.008076178,0.008921386,-0.013283042,0.008264075,-0.09041121,-0.07674577,-0.005064442,-0.06007623,0.07051065,0.09922989,-0.125808,0.025158986,-0.054192923,0.037843045,0.037348624,0.00832896,-0.0335013,0.05610569,-0.074498534,0.005847726,0.04722762,0.11410826,0.012351013,-0.06525225,-0.025527777,-0.016498351,-0.04918776,-0.07945653,0.0002684909,0.06713234,-0.008381684,-0.02000218,-0.024322547,-0.010850604,-0.026247352,-0.0074527543,-0.02936221,-0.030723523,0.118642226,-0.09026292,0.045318536,-0.043197207,0.029749185,-0.08609138,-0.066092245,0.0029087677,0.009137456,-0.04174514,0.026041238,0.005092545,-0.08000323,-0.038041886,0.027145723,0.017259179,0.04853295,-0.042060204,-0.046296857,-0.019857977,0.0066942135,0.010486442,0.031494968,0.056608465,0.06822609,-0.006617526,-0.019540139,0.05965268,-0.045956887,0.0053609107,-0.12833703,0.05228661,-0.0066525,0.06810175,-0.037984207,-0.048134517,0.060933556,0.12538446,-0.03522525,-0.068999976,-0.024284843,0.052278683,0.011495806,0.05182573,0.006176407,0.06290592,-0.021083338,0.056972485,-0.0062770266,0.043170504,0.018332398,0.07749147,-0.027404722,-0.06606399,-0.05477308,-0.01608416,-0.05341004,-0.03256516,0.028832959,0.09133289,-0.0657154,0.018268278,-0.023644838,8.530023e-34,-0.030288525,0.025913237,0.050867632,0.0012012068,-0.019561267,-0.030132663,-0.102836646,-0.0454739,-0.0414919,-0.05685816,-0.030690651,-0.10180311,0.045210127,0.02059292,-0.05015197,-0.064793035,-0.025005344,0.0950453,0.080391526,-0.024115728,0.007961361,0.054245036,-0.016263023,0.072623156,0.037499465,0.08018422,-0.099768795,0.06510783,0.04294351,-0.014821685,0.080305934,-0.03963635,-0.118079126,-0.0955891,0.023623979,-0.03345107,-0.044751324,0.031428743,0.021952584,0.06167607,-0.04522335,-0.032768954,0.04048087,-0.021041494,0.008528502,-0.11314062,0.0139926495,0.06748499,0.00036231245,0.028199831,0.044722423,-0.06617507,0.10240488,-0.0140862465,-0.06394308,-0.010848616,0.050298117,-0.023679564,0.004182257,0.058045432,0.038890406,0.059661273,-0.023493003,-0.0040563173,0.004086653,0.014880102,-0.04216944,-0.09285777,0.0431284,0.07904857,-0.009218949,0.0047303247,0.05831361,-0.059326597,0.00041107254,-0.010034567,-0.018213052,0.04747267,-0.07343156,0.043268923,-0.033621762,-0.037419796,-0.01897145,-0.036814656,-0.021797717,-0.04701249,0.0428755,-0.0813973,0.018152738,0.0634288,0.050681237,-0.044850968,-0.07792359,-0.010409623,0.08392643,-2.1681415e-33,0.059452713,-0.0158076,0.026579618,-0.0748924,-0.040631603,-0.014404179,0.03458551,-0.007377154,-0.016034517,-0.078826405,-0.06207854,-0.05176409,-0.020058816,-0.022595657,-0.04981192,0.0135778785,0.0072487122,0.06276932,0.0061090626,0.04385246,-0.017173367,0.10941552,0.041207507,0.062434435,0.034675743,-0.039294805,0.02886031,0.033180837,0.061768424,-0.03564665,0.01994088,0.017487034,0.0036180501,0.020097544,-0.013565193,0.023250336,-0.0476973,0.05152849,0.06567888,0.09991569,0.045002937,0.07597318,-0.029565614,-0.0069697276,0.042224616,0.031583805,0.02557076,-0.015678698,-0.012001728,-0.061569866,0.08846817,0.029440636,0.0121316295,0.037306756,0.086146384,0.05486562,-0.056402765,0.08521217,0.026790835,-0.05305201,-0.03139445,-0.106361836,-0.045369163,-0.039388437,0.07359267,0.028788803,-0.029426677,0.050236005,0.023124473,-0.027539302,0.006885331,0.0764098,0.015140134,0.026821297,-0.017703306,-0.012954708,-0.036234435,0.038223237,-0.001476736,-0.034042556,-0.042428765,0.0787747,-0.09131811,-0.13922778,0.03185339,-0.07744304,0.02970469,0.050008066,-0.03325626,0.008267726,0.004933118,-0.03458269,0.034235757,0.049952377,0.05102412,-4.1153744e-08,0.041183557,-0.005191587,0.05258994,0.0058489656,0.027178466,0.025763977,0.046412535,-0.01627905,0.043730315,-0.0034519874,0.0012940323,0.037924867,0.035401553,0.04712504,0.078709915,0.039347876,-0.11765294,0.006747111,-0.034384064,-0.018062962,-0.039703406,0.024437202,-0.14542824,0.098809555,-0.017870255,0.015830511,0.055615697,-0.023923999,-0.013130262,-0.027174221,0.08333198,-0.02797758,0.04017601,-0.07599202,-0.04300296,0.003708087,-0.03774752,0.04529235,-0.0306356,0.0021102044,-0.037643816,-0.09370038,-0.006845912,0.013468947,-0.058597576,0.009510231,-0.058683217,0.028655803,0.00066694175,-0.014010014,0.02649794,0.057132334,-0.047033478,-0.14322633,-0.106184505,0.008283587,-0.0118913,0.01179737,-0.047199126,-0.06675191,0.08217357,-0.027663887,0.0667873,-0.02208103 +2.4.2.15,Also acts on deoxyguanosine. ,384,1.0,-0.031001262,-0.052467104,-0.029141083,0.056323778,-0.0019464629,-0.055121254,0.07363692,0.03216531,0.026168197,0.047139816,0.034438763,0.03955164,-0.025826108,0.10825412,-0.036935564,0.09907743,-0.04051732,0.039647684,0.019537082,0.017387938,0.03278432,0.07364865,-0.030954301,0.0028771085,-0.0097371945,0.023689948,0.0011469425,0.026288806,-0.013058167,-0.044597015,0.0022964652,0.031418044,-0.0007122579,0.0076308115,0.00049412006,0.06818814,-0.05864875,0.0039208718,0.016199134,0.037106115,-0.0008226297,-0.007987326,-0.035055634,0.006331147,-0.010529217,-0.036065623,-0.061703816,0.04861643,0.07748797,0.044957228,-0.0016804499,-0.061662965,-0.017519256,0.053705174,-0.0023537653,0.01453886,-0.10851988,0.0049542207,-0.026027096,-0.011666056,-0.0565457,0.015012036,-0.025504967,0.058225896,0.07358984,0.013919032,0.070005946,-0.027298568,-0.030870188,-0.0493183,0.057540048,-0.06686811,0.07811616,-0.017893985,-0.044470657,0.0077433623,-0.022217844,-0.08051845,-0.03674685,-0.018293118,-0.005277426,0.03860897,0.06125481,0.036464296,0.07109557,-0.02424546,-0.0015547185,-0.06938276,-0.073258966,0.08831416,0.0341682,-0.0322478,-0.029951798,0.04627662,0.012470273,-0.014802001,0.035312157,0.028564155,-0.061180953,-0.0065882024,-0.04820602,0.02036717,-0.06153701,-0.044294156,0.0100007,0.02780195,0.055557188,-0.05386022,-0.007612025,-0.009578099,-0.036505923,0.008707936,0.013994674,0.046046223,-0.035575796,0.10495522,0.059544846,0.043653734,-0.02582505,-0.03759843,0.019627467,-0.075611554,-0.018808978,-0.05797945,-0.0484757,0.06520276,-0.024621367,-6.064333e-34,0.054966513,-0.019930955,0.005347161,0.0351001,0.07532424,0.036700893,-0.05605663,0.024980947,0.03399273,0.006472203,-0.117047615,-0.036737163,0.08282985,0.032347564,-0.08341014,-0.021851618,-0.07715566,-0.0036001161,0.046478875,0.0027575907,0.034928374,0.070593454,-0.06347044,-0.010438509,-0.09856442,0.08620736,-0.065076396,0.012117999,-0.021059012,0.002130914,-0.006620084,-0.09503984,-0.038762167,0.019983657,0.00057813514,0.08386015,-0.024327585,-0.020718893,-0.032277394,0.063711576,0.008665329,-0.017267242,-0.10116436,-0.0370636,0.040808547,-0.06098953,-0.079484,0.04178021,0.02109678,0.05929797,0.07734158,-0.03770182,0.05873311,-0.088881336,-0.05528857,0.014590823,0.0048035304,-0.08062971,0.025475234,0.09478102,0.04643476,0.022893444,-0.035599485,-0.036646105,0.045894645,0.019254684,-0.101255335,-0.06380789,-0.06776562,-0.017082138,-0.08320041,-0.018777104,0.09168603,0.0104485275,-0.006245745,-0.019954937,-0.0046352483,0.05260046,0.01748943,-0.012825257,0.023823561,-0.106643036,0.0833286,-0.01923742,0.033335734,0.047591623,-0.029436745,-0.06563654,0.00046843203,0.045341797,0.023059327,-0.04007719,-0.054164566,-0.105923906,0.029240796,-1.3755873e-33,0.012505853,-0.09832351,-0.009335539,-0.003304159,0.01131738,0.073458165,-0.0204647,0.068166,0.047093544,-0.03861408,0.050472558,-0.025608249,-0.03190235,-0.009590129,0.0053187776,0.0584418,-0.00801407,0.059020877,-0.08341682,0.0074958606,-0.024914015,0.10657727,0.045588072,0.040979758,0.046289213,-0.016312812,0.031247491,-0.03150616,0.029293329,0.05979816,-0.02906557,0.0077969315,-0.087045886,-0.023025146,-0.03894988,0.09048922,-0.06032023,-0.018551972,-0.087172344,-0.058424775,-0.00040302658,-0.022751383,0.08331706,0.14805798,0.04599184,0.09696523,-0.07126812,-0.058784463,-0.10303008,0.02913403,0.010066434,0.028052453,-0.027805977,0.060574196,0.07424637,0.03268843,-0.02273821,-0.112374306,-0.027898364,0.039887954,0.0151414005,0.007952158,-0.07594405,-0.05814692,0.09275698,0.031898867,-0.089438215,0.07153251,0.09986438,-0.009446699,0.09952625,-0.03631512,-0.09889831,-0.025862604,-0.11982456,-0.00080325356,-0.05241492,-0.045994967,0.025431057,-0.04321692,-0.04100352,0.0013862222,0.021736145,-0.027883101,-0.04098285,-0.027740005,-0.029983856,0.05563096,-0.05093157,0.028889028,-0.046073787,-0.026009444,-0.09889984,0.027440706,0.05337225,-1.8818527e-08,-0.019523833,-0.041755836,0.07549194,-0.019998513,-0.03149973,-0.015365757,0.11409367,0.08467238,0.029571423,-0.060619246,0.009788372,0.11415008,0.08178591,0.0009454583,0.047492087,0.0037607725,0.03021703,0.04180001,-0.04297338,-0.0062345504,-0.07856433,-0.037650958,0.014036529,0.047678635,-0.002268019,-0.06468011,0.054224994,0.09403927,0.07136185,-0.05752817,0.021388276,-0.037385475,-0.058490943,-0.059338648,-0.030691572,-0.008934483,0.04962669,-0.05386569,0.0076040244,-0.014364334,-0.048684098,-0.019466849,-0.027943091,0.045238934,-0.02092818,-0.0025091989,0.039434507,0.023027508,0.034585755,0.007034592,0.08598923,-0.0025697334,0.018085375,0.002117589,-0.08231259,0.054377526,0.013401209,-0.02829907,0.031064965,-0.040238425,-0.021656254,0.03718386,0.16407086,-0.0069049327 +2.4.2.17,Involved in histidine biosynthesis.,384,1.0,-0.0019787513,0.04102024,-0.15989561,-0.051919077,-0.0010785343,0.049394995,-0.012409848,0.06103054,-0.013659477,0.018180959,0.011886611,-0.029157182,-0.013797789,0.030757375,-0.0540156,-0.036209818,-0.12174634,-0.00916737,-0.06569075,-0.099043235,0.006478212,0.05843998,-0.034224972,-0.04180331,-0.018377176,0.0017969796,0.022624906,-0.03456344,0.009554908,0.0017999613,-0.021544512,-0.089035496,0.11672749,-0.08278319,0.10385085,0.06511858,-0.03883699,-0.0032085145,0.09620681,0.08650229,0.01909148,0.014676521,-0.052084725,0.031990115,0.037137944,0.0029606284,-0.005052777,-0.013115709,-0.0017178975,0.07972139,-0.041364964,0.03635747,0.0035820429,-0.065213874,0.040939797,0.005695836,-0.05258427,-0.020983702,-0.042191215,-0.037461996,0.025107315,-0.06522112,0.02278623,0.006405823,0.036773503,-0.043261543,0.101183936,-0.04616589,0.05351775,-0.049456395,0.009094063,-0.06486973,-0.0100949975,0.11801767,-0.0014406206,-0.06581038,-0.04475224,0.003611142,-0.0034749943,0.040614054,-0.018453473,-0.056715768,-0.037771888,0.064060874,0.021591235,0.033341207,-0.008365991,-0.025106516,0.05155449,0.085409366,0.01751985,-0.099612966,-0.038000774,-0.07593919,-0.042627778,0.00040086647,0.03402132,0.00627197,-0.025245829,-0.055128943,0.055264127,0.013253352,-0.14735591,-0.00591316,-0.018078465,0.013576487,0.014632675,0.07190624,-0.08022192,0.054760676,0.028505642,0.026804011,-0.0007183359,-0.020468814,0.015657218,0.13997601,0.03758045,-0.03367166,-0.023958316,0.008788411,0.020201834,0.01589222,0.028618274,0.13194104,-0.059644032,-0.055662457,-0.039438985,-2.5384172e-33,0.051930945,0.051667318,-0.050207693,0.025847431,0.013575078,0.049355794,-0.065670155,-0.014957992,0.033252146,-0.097308375,-0.074321866,-0.07908747,0.075452045,-0.0313047,-0.08761019,-0.027528234,0.0032107073,-0.02863253,0.0968882,-0.040310342,-0.03487745,0.13194823,0.04845908,-0.016336916,0.017560266,0.024416788,-0.055271704,-0.006820373,0.046924714,-0.013371466,-0.019736903,-0.0097323535,-0.007876251,0.019722968,0.060856767,-0.016671585,-0.07258649,-0.049259312,0.0107319765,0.09327941,0.023533225,0.04026724,0.009749521,0.0005552273,0.048552677,0.0035505823,-0.04153488,0.036326785,0.008563252,-0.016921066,0.014605697,-0.0074408804,0.13255446,-0.031927,-0.046160795,0.036218755,0.0065462333,-0.068519734,0.009138779,0.12690476,0.03052724,0.056702357,0.011510921,0.08272651,0.028092666,-0.047861822,-0.085150465,0.007911881,-0.0029819498,0.03810759,-0.032283995,-0.062217884,0.023946822,-0.039922845,0.04265919,0.015154388,-0.11352312,0.10492709,-0.07309389,-0.027795732,0.027409453,0.008943964,-0.0123777175,0.014094638,-0.050444882,-0.009153721,0.02502122,-0.06834689,0.025264973,0.056621592,0.013582604,-0.075239964,-0.01353415,-0.044584032,0.049940474,-2.0183905e-33,0.037273884,-0.11199243,0.041979212,-0.048740953,-0.008027229,0.04652727,-0.007211469,-0.002022894,0.032536577,0.029402284,0.018933157,-0.03555225,-0.025259372,-0.060750667,-0.09691719,0.03888748,0.08906711,0.12540154,-0.02668058,-0.013990003,-0.043101538,0.020631704,0.027893191,0.0047705295,0.007199561,0.017907446,-0.0003259492,0.0045125666,0.04057807,0.0071561257,-0.02385841,-0.024408806,-0.09360446,-0.08763581,0.06130854,0.04917204,-0.081186354,0.032457687,0.008799868,-0.029860428,0.024349531,0.0073421514,0.046741296,0.06967389,0.031632822,0.054827746,-0.061614394,0.05948151,-0.05045074,-0.07088825,4.7872385e-05,-0.031316016,0.008152613,0.008566887,0.07711637,-0.0072653545,0.0418849,-0.0058396817,0.035768237,0.041844852,0.010941148,-0.04810887,-0.0035129064,-0.050766546,-0.02490377,0.0110275075,-0.0880124,0.002773678,0.064329304,0.022534262,0.016200783,-0.058568645,0.06707448,0.01683207,-0.090176605,-0.0046716016,-0.08119974,-0.069259,0.06800714,-0.013135311,-0.099412665,-0.030019686,0.0018290643,-0.031582467,-0.04974947,-0.08627751,0.043158367,0.025104241,-0.014447839,-0.026044672,0.03939725,-0.034424245,-0.03756975,0.052748952,0.014526857,-2.0412912e-08,0.06997136,-0.090712935,0.021441093,-0.021640286,-0.03702668,0.039653637,-0.008516122,-0.019193493,0.050629497,-0.023919899,-0.032999158,0.048416417,0.024456732,-0.020749751,-0.008631979,0.036681596,-0.075916104,0.0045624645,0.015466157,-0.038744256,-0.063849516,-0.0032170347,-0.088736326,-0.019505378,0.00797502,-0.029885583,0.006113035,0.05004562,0.055613417,-0.08448802,0.079921156,-0.042399086,0.028937042,-0.07059606,-0.047866926,0.00861222,0.009305058,-0.02883315,0.106374174,-0.07500946,-0.0059940508,0.0060102446,-0.06732014,0.08217959,0.025583476,0.018611955,0.020536901,0.10392632,-0.052329186,-0.027216025,-0.046571903,0.017473597,0.027697485,-0.040189836,-0.010886943,-0.034445364,-0.00886417,-0.0816915,-0.0142421825,0.031310447,-0.019052142,0.013748073,0.16947629,0.01790418 +2.4.2.18,"In some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan [EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)].",384,1.0,0.0069633215,-0.04398463,-0.102483414,-0.021924805,0.056593884,0.044829573,-0.0057090917,-0.02311546,0.060139373,-0.011157298,0.040993206,-0.06854564,-0.07357378,0.07602713,-0.04014387,0.0142035205,-0.07101505,0.0056477063,-0.028723355,-0.09720123,0.05491165,0.08024484,-0.013926364,0.0034020208,-0.032507278,-0.039801463,0.0028662372,-0.07216411,-0.015646882,-0.042772193,-0.02274681,-0.10269311,0.009258287,-0.046115734,0.03336825,0.10632631,-0.026321318,-0.0420209,0.0634175,0.02345196,0.011791521,-0.027868077,-0.040992655,-0.03039545,-0.03423458,0.07568172,0.03563802,0.017408464,0.037965123,-0.051937517,-0.058216397,-0.05395783,-0.064561285,0.0135317985,0.06421513,-0.0037626433,-0.043834507,0.021738494,-0.06714771,0.031420946,0.015320556,0.054478377,0.05588776,0.005631999,0.07203124,-0.051814377,0.030026108,-0.078119114,-0.006510562,-0.01429984,-0.06922369,-0.055475533,-0.0027661035,0.031136138,-0.023684287,0.061830122,-0.018815458,-0.008732299,-0.004792859,-0.026268637,0.046083756,0.021119379,-0.009152513,0.06129906,0.005040462,-0.037371527,-0.033813875,0.07364726,0.03561233,-0.043551996,0.060030855,-0.021635737,0.022791618,-0.011750494,0.005849668,0.021571254,0.0025312519,-0.027860405,0.060517985,-0.0766291,-0.016703255,-0.012761098,-0.004256266,-0.105858535,-0.02794,4.7369263e-05,-0.02834805,0.07705525,0.058548544,0.0019128658,-0.05489487,0.018951684,0.07042113,0.047386214,-0.021390164,0.05215837,-0.048804276,-0.05542508,-0.0058646016,0.036515884,0.027308593,-0.00095715275,0.07646144,0.14419656,-0.023549208,0.023360403,-0.104178555,2.4388668e-33,0.08962629,0.050560407,0.035049796,-0.008818853,-0.02096458,0.053077124,-0.026517693,-0.011283589,-0.06420286,-0.027987372,-0.024327293,-0.1120813,0.05813447,0.04054728,-0.00012836212,0.03552862,-0.087686345,0.0032861952,0.036450777,0.047748297,-0.06669934,0.050091125,-0.057188015,0.012959948,0.025417918,0.06665876,-0.02142029,-0.0006478277,0.017210266,-0.033651505,-0.010871963,-0.033647098,-0.14059317,0.011261782,0.03599899,-0.06811829,0.0015885524,-0.030273244,-0.08237373,0.017611053,0.005868787,0.039906975,0.0065033645,-0.020364463,0.0933086,0.019889705,-0.08246748,0.11312839,0.0998544,0.02543941,-0.012573256,-0.037643585,0.12414908,-0.061466124,-0.05399387,-0.006721979,-0.04815456,0.0013403554,0.03398729,0.033804324,-0.111787,0.028016606,-0.052132424,-0.023132533,-0.0066189836,0.024448123,-0.021759182,-0.07859778,0.012977153,0.083013825,-0.039887547,-0.046126835,0.050488718,0.029111208,-0.023935493,-0.07549451,-0.053093355,-0.042047463,-0.020824693,0.058940798,-0.012710767,0.0014628,-0.0004796479,-0.024509134,-0.015059389,-0.042235322,-0.021486621,-0.0720221,0.011306165,0.049422584,0.021434616,-0.03935543,-0.101098806,0.07701939,-0.01886944,-4.7427777e-33,0.08598519,-0.08718072,0.009511218,-0.054328643,-0.03873082,0.043149013,-0.014264197,-0.0074482798,0.046346247,0.02181199,0.053229254,-0.06647301,0.112131774,-0.02507327,-0.003841656,-0.017999556,-0.038355768,0.106651105,0.08524136,0.017379373,0.011017069,0.019701794,0.010501519,0.008704109,0.07680407,0.04994398,-0.09293937,0.099090144,-0.018603435,0.034354974,0.038352843,-0.03962123,-0.07657053,-0.023727335,-0.019805597,0.036491238,-0.068633735,0.027945481,0.07980308,0.0074339597,0.041529395,0.08895437,0.090184316,0.029338105,0.028168308,0.09030474,-0.025419418,0.058564443,-0.01640478,-0.080202736,-0.04248087,-0.045080617,-0.03171662,0.012444253,0.04450731,0.06582018,-0.017079974,0.07359764,-0.025129821,-0.049549524,-0.05889102,-0.08672629,0.11088776,0.001699704,0.006538973,0.07283813,0.0014057673,0.013907521,0.07774311,0.031029979,0.046215884,-0.042361848,0.04094705,0.07172664,-0.033921774,-0.05485265,-0.088269316,-0.077249385,0.009286327,0.0061312807,0.04981956,0.03224892,0.017817505,-0.042666864,-0.023939366,-0.040110715,0.042886794,0.15447345,0.043658804,0.011726023,-0.0015486496,0.011862727,-0.04422389,0.064951666,0.048574798,-4.72904e-08,0.092372544,-0.07731148,0.030096887,-0.12708077,-0.028020931,0.023965841,0.040090393,0.044083804,0.03713363,-0.029883932,0.0065540774,-0.016778741,-0.02530516,-0.007714854,0.036035754,-0.033019435,-0.042170614,0.048704,-0.013839968,-0.011113622,-0.041578393,-0.052588828,-0.07907744,0.01635082,-0.006422065,-0.043238174,0.06431864,0.014622294,-0.028721552,-0.031417802,-0.044089388,0.012469784,0.014184564,0.00043479365,-0.053913612,0.045463618,-0.094304524,0.0077028037,-0.0020765653,0.0070089763,0.0018117252,-0.0550083,-0.062153477,0.022650948,0.064353436,-0.039322663,-0.01387508,-0.05218079,0.02517306,-0.050505657,0.011517449,-0.019262206,0.0014011892,-0.06302846,-0.08639326,-0.0026706737,-0.057050884,-0.039407313,-0.006867897,-0.051023234,0.02765496,0.03879265,0.18714763,-0.033198442 +2.4.2.19,"The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes [3].",384,1.0,-0.030787902,-0.020997765,-0.0996184,-0.03969783,0.06570972,0.03131163,-0.029573666,0.005169717,0.03345791,0.10788756,0.0017529282,0.014602058,-0.097748056,-0.009196686,-0.06567318,0.041612554,-0.044349235,-0.052728288,0.06160857,0.014877181,0.04768246,-0.03270813,-0.027218409,-0.02968638,0.05947996,0.004183447,0.03851564,0.0049152686,0.019291447,-0.031996686,-0.07472299,0.006213488,-0.008906367,-0.059360437,-0.039472483,0.045703888,-0.06833442,-0.035399977,0.05057325,-0.037343986,0.027853744,-0.008685672,-0.051837437,-0.005506696,-0.044109207,0.029944913,0.012335982,0.1094003,0.004547156,-0.023572205,-0.043799467,-0.045103166,-0.05529125,-0.033342786,0.0042817513,0.06600252,-0.032134634,0.012273355,0.04184064,0.020061625,-0.0036499784,-0.0077341516,-0.05723718,-0.015068645,0.084534116,-0.09264342,0.0329494,-0.020900346,-0.040569223,-0.039375093,-0.03346197,-0.033757295,-0.0063126395,-0.013197715,-0.0019463516,0.07752675,-0.003004119,-0.007066279,-0.020930454,0.044529647,0.038894664,0.05229235,-0.0024582252,0.06620162,-0.0029197445,-0.008066877,-0.029159332,0.0867124,0.098756626,-0.030773593,0.015786402,-0.014609667,-0.022641407,-0.018258093,-0.12694313,0.085555255,0.040246002,0.030909624,0.1253931,-0.058315214,0.041257057,0.031302173,-0.005767527,-0.08476367,-0.03058586,0.044723537,0.005928136,0.14647916,-0.01530544,0.008020112,-0.030988839,-0.023330605,0.075589985,-0.055746164,-0.07826929,0.074421674,0.023685958,-0.07342391,-0.050622705,-0.049843136,0.03731441,0.04263956,0.0357211,0.060005374,-0.006215208,0.030832278,-0.11912038,3.632346e-33,0.08544714,0.04319408,0.013791345,0.010429303,-0.0120082,0.027949495,-0.026286986,-0.018546958,-0.06675226,-0.023632778,-0.05965091,-0.1206994,0.0433044,-0.019590503,-0.055342175,0.030475194,0.003945469,-0.1027662,-0.051754873,0.06236744,-0.009946874,0.060652785,-0.058324095,0.008203896,0.012764327,0.058754846,0.013779243,0.007916436,0.019136732,-0.027327135,-0.00037930827,-0.09811651,-0.09661287,0.021109818,0.087305464,-0.03423353,-0.0051600668,-0.009935871,-0.061858248,0.05128722,-0.021621441,0.07950211,-0.035240196,-0.05191617,0.07706871,-0.06242296,0.02894087,0.060723484,0.082174666,-0.0034056397,0.040316302,-0.020861791,0.08755456,-0.037345346,-0.062891066,0.06455095,0.013502296,-0.015198388,0.046599038,0.04936526,-0.009725569,0.006151229,-0.03220698,0.00013849793,-0.03358797,0.050715663,-0.026836881,-0.08325234,0.05887193,0.021129211,-0.0777617,-0.016367259,0.11117587,0.018834753,0.011287613,-0.016335078,-0.005115768,-0.06523755,0.02876395,-0.022426166,0.03479348,0.05464541,-0.0011521793,-0.004311022,0.04057183,-0.056642864,-0.061869334,-0.049529042,-0.026121123,0.051009506,0.010793872,-0.029853288,0.0028320532,0.024316953,0.001735868,-5.936163e-33,0.06982482,-0.102205426,0.011268053,-0.10596623,-0.101242796,0.08633878,-0.023495298,-0.114966065,0.008388451,-0.0018843507,0.01655167,-0.058773424,0.04235515,0.026804818,0.037272535,-0.020463904,0.015026529,0.11732899,-0.0054118466,-0.06387836,-0.054638386,0.05250241,0.023756271,0.0044324403,0.061932433,-0.008225166,0.0068063946,0.08515026,0.019444892,0.09060164,-0.017539123,-0.07800719,-0.048672814,-0.02296516,0.015198001,0.06769797,-0.062106088,0.0054360847,0.025426667,0.03913152,0.0014673246,0.013925936,0.0723005,0.051351678,-0.018503493,-0.018624825,-0.1101132,0.008531146,-0.011709889,-0.07902086,0.03571755,0.0130862,-0.05225011,0.008050912,0.056316476,0.029537814,0.037485555,0.03215995,0.07153626,-0.040011037,-0.050655235,-0.13324693,0.04068471,-0.0852434,0.058376603,0.0926547,-0.06081164,0.084287226,0.026155747,-0.011677796,0.03417131,0.10676192,-0.05265996,0.047442738,0.03567234,-0.044464648,-0.043366954,-0.06960091,-0.016015576,0.0015716034,0.03452669,-0.025180057,-0.001166947,-0.044880804,-0.05853519,-0.080658264,0.026243493,0.10342931,-0.04521067,-0.0099411495,0.019441983,-0.016391914,0.024113854,0.06120654,0.09079516,-3.8437257e-08,-0.008902336,-0.013625537,0.009622387,-0.03430462,-0.031966537,0.082354814,0.0047038877,-0.028788425,0.045876745,-0.0002703661,-0.022759363,0.058242857,0.036698658,0.008173611,0.06446641,0.023664955,-0.036998894,0.017323807,-0.043676578,0.059116017,-0.0009606876,-0.0033496881,-0.11132686,0.027012661,0.014595891,-0.10492338,0.025008272,-0.015920995,-0.025850434,-0.024735065,-0.06918506,0.031803682,-0.013422503,-0.02914615,-0.060577586,0.03744142,-0.00015610844,0.008256648,0.022588354,-0.05347736,0.026498633,-0.021963775,-0.092377156,0.03394176,-0.047023345,0.015484213,0.03752001,-0.022343768,-0.055846054,-0.015729029,0.07675905,-0.026620053,0.049597036,-0.06397413,-0.07907802,-0.022985632,-0.051906276,-0.03707784,-0.018051518,-0.040329084,0.034820188,0.065034606,0.1809405,-0.029267471 +2.4.2.20,"Acts (in the reverse direction) on uracil and other pyrimidines and pteridines containing a 2,4-diketo structure. ",384,0.99999994,-0.027630879,-0.07005579,0.01638756,-0.062005863,-0.020317612,-0.016197661,0.025816943,0.0531951,0.03174241,0.05333621,0.016154781,-0.0047056307,-0.061778996,0.08060853,-0.027939128,0.0029989036,-0.10483011,0.037234854,0.024549825,0.012608012,0.021806061,-0.0217729,-0.02111149,0.0019815008,-0.10607272,0.044255365,0.0484183,0.05532341,-0.007628797,-0.111511506,0.01044127,-0.066753194,-0.033084866,-0.05724367,0.026696248,0.09410426,-0.07855975,0.014459007,0.041865356,0.0030772097,0.08687379,-0.02996079,-0.014529171,0.0135836145,0.017370012,0.018854765,-0.017712226,-0.010202732,0.013759356,0.047228336,-0.04737564,0.05102416,-0.0678424,0.08071924,0.014516304,0.02673141,-0.08816566,0.06085119,0.009481975,-0.027164109,0.05532905,-0.021171886,-0.014259677,-0.025113443,-0.039107036,0.04622741,0.028436257,-0.011471634,0.03495724,-0.03058075,-0.02607043,-0.01453237,0.057572164,0.023342077,0.019922609,-0.033430338,-0.03820922,0.011051495,-0.04485288,-0.041430995,-0.013490704,-0.07294408,0.04951248,0.03433408,0.00249836,0.05794123,-0.04481769,-0.1126257,0.06974719,0.028721863,0.05020338,-0.004787019,-0.0146485185,-0.0547154,-0.00027542555,-0.02576806,-0.057346664,0.053875778,0.041885514,-0.0016760933,0.022192577,0.020630216,-0.1686226,-0.048046038,-0.036628056,-0.04851768,0.028331732,-0.048200577,-0.041852225,0.0026457962,-0.04861767,0.044156265,0.044052865,-0.0032823775,-0.08613135,-0.015288854,0.0063711274,-0.040162813,0.0033147356,-0.051905043,0.04103296,0.01048541,0.032905065,0.07272935,-0.069460444,-0.022687912,-0.039175298,-5.542874e-34,0.011739648,0.070344694,0.07162638,-0.007069449,-0.010082697,-0.010692705,-0.045162156,-0.07932111,-0.046585184,-0.085216455,-0.05231696,-0.07987971,0.057687793,0.056164037,-0.07310864,-0.07528491,-0.0026017171,0.10514926,0.00720223,-0.11256953,0.063381515,0.18270937,-0.024915494,0.00022062889,-0.013978561,0.07949785,-0.06451079,-0.01260101,0.027753541,0.00026963846,-0.015888587,-0.0042198827,-0.05753641,0.050451174,0.047999088,0.09501317,-0.083180524,-0.06817839,0.05316667,-0.026897233,-0.049740285,-0.027205799,-0.055915885,0.035528652,0.018519621,-0.031036712,-0.047168817,0.061892454,-0.046465006,0.04579053,0.015053698,-0.08647418,0.0733518,-0.026675044,-0.067012675,0.004130536,-0.0347522,-0.074080415,0.062309384,0.09387453,0.087682866,0.09975664,-0.06319726,-0.033395056,-0.014742414,0.010838206,-0.065912485,-0.02313895,0.08910468,0.033127442,-0.030575382,-0.00250805,0.068659045,0.010437268,0.05687257,-0.0043413136,-0.061664358,0.043137383,-0.022520976,0.0189808,-0.025995782,-0.06605883,0.03842501,-0.00011541356,-0.010069326,-0.022087384,0.019848188,-0.10086977,0.011992484,0.06436527,0.06388491,-0.03631821,-0.05492522,0.011632885,0.038168263,-1.4408312e-33,0.09348896,-0.015694326,0.053872023,0.027926117,-0.07110357,-0.017007591,0.016798044,-0.04442093,0.04507354,0.0031075731,0.059205543,-0.04509802,-0.062493004,-0.09195807,-0.069911025,0.03612055,0.09507438,0.024948686,0.03776557,-0.07001441,-0.06635107,-0.010197669,-0.009016042,0.11316331,0.028568134,0.020583648,0.10205852,-0.061871793,0.09594229,-0.007259394,-0.049683355,-0.019522134,-0.029805472,0.0061309636,-0.0033880442,0.058221463,-0.1075457,0.045436207,0.013965003,-0.06711075,-0.007175504,-0.037924096,0.03101127,0.06265199,-0.013526432,0.048535295,-0.0068513514,0.057959713,-0.07713108,-0.10004555,0.06409618,0.013171763,0.017315945,-0.015707415,0.10112964,0.04334872,0.0041382033,-0.040368907,0.0003545017,0.017017607,0.01320504,-0.0060753888,0.0012834353,-0.030425815,0.037962914,0.0003516169,-0.06273134,-0.027868785,0.029049171,-0.0021719208,0.067641154,-0.0041032303,0.059358012,-0.05509482,-0.087476276,-0.052415833,-0.0143730845,-0.055620234,0.011718446,-0.011392975,-0.03919859,0.016731653,0.025966987,-0.013929122,-0.051341955,0.0027395866,0.0144332675,0.06658841,-0.0366669,0.028237818,0.023192156,0.02063286,0.07096793,0.07917374,0.1051261,-2.8414963e-08,0.039122302,-0.03218967,0.025478674,0.021976616,-0.10337684,0.041214924,0.005737439,0.06651758,-0.012481281,-0.014555176,0.021328127,0.0059884996,0.07279848,-0.031611867,0.050193097,0.094958365,-0.030951332,0.015033288,0.009314448,0.037278004,-0.11439637,-0.010096211,-0.113209434,-0.029829247,0.03535788,-0.00019182525,0.03096371,-0.006153251,-0.047675885,-0.0055764597,0.08031241,-0.07194174,-0.024546372,-0.05259764,0.0116789425,0.059372306,-0.05436906,-0.008074997,0.016310731,-0.021506853,-0.054972984,0.026014633,0.005827692,0.06959178,-0.049370937,0.017530777,-0.07063518,0.026150482,-0.0416762,-0.0043753404,0.06729349,0.04060518,0.035106882,-0.033064853,-0.061185535,0.09288977,0.009036403,-0.094570234,-0.0066528325,-0.001959515,0.04973776,0.048970006,0.09134303,0.087638415 +2.4.2.21,"Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin-biosynthesis pathway and is a substrate for EC 2.7.8.26, adenosylcobinamide-GDP ribazoletransferase [4]. It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73, alpha-ribazole phosphatase.",384,1.0,0.022081092,-0.0073185675,-0.109200485,-0.074535,0.028057748,0.018240435,-0.0126026245,-0.0055175326,0.058170542,0.079662144,-0.014168515,0.036137793,-0.030966403,0.07694129,-0.07248769,-0.02889505,-0.07897393,0.014718581,-0.008614012,-0.028055048,0.053218774,0.09351724,-0.0065390742,0.0568925,-0.022418818,-0.0053605563,0.0807402,0.05056466,-0.010789619,-0.076958016,0.042077214,-0.08987398,0.06607853,0.008977844,0.0184936,0.07771615,-0.0038675356,-0.12493965,0.043245275,0.106169164,0.046324812,-0.02601215,-0.015733704,-0.028487567,-0.034474913,0.010490244,-0.032372873,0.09219668,0.038789876,0.021840049,-0.047477044,-0.06937497,-0.031300396,-0.06577854,-0.0064414046,0.08275028,-0.040859703,-0.04752226,0.0009811824,0.018674439,0.011536989,-0.022328401,0.0068354765,0.09770919,-0.012529555,-0.02226114,-0.004861337,-0.067030266,-0.020565143,-0.016012961,-0.050168235,-0.09591958,0.030667165,-0.04531521,-0.019818082,0.032005947,0.023814473,-0.06239516,-0.030404482,-0.1129974,0.020080829,-0.035933536,0.013017959,-0.027503211,-0.022558736,0.039279163,-0.029403538,-0.012480238,0.04907963,0.06372514,0.01726423,0.027776027,0.14641167,-0.00461517,0.011768998,0.08055231,0.026089955,0.076241784,-0.023951808,-0.050636183,-0.011365227,0.09567299,-0.010084765,0.004758024,-0.028678311,-0.013543105,0.034770485,0.09223434,-0.0723203,0.0033799883,-0.038594052,0.025564918,0.003239223,-0.035958413,0.07152196,0.05123584,0.052627716,-0.0519043,-0.014220929,-0.02459748,0.024255095,-0.070364,0.011544628,0.017287826,-0.04937465,0.100836046,-0.09639983,1.356691e-33,0.06239143,0.080323786,0.03543954,-0.005429066,-0.047985252,0.04215323,-0.13255036,-0.01326955,-0.020744164,-0.07464824,-0.089471094,-0.020495478,0.06808328,-0.04507679,-0.025307378,-0.047802426,-0.042852663,0.10051743,0.0022045858,0.05484016,0.057574995,0.026559412,-0.04764614,0.05841175,0.021225108,0.034167103,-0.033960383,0.009003863,0.07082593,-0.033287082,-0.053041544,0.015277614,-0.08649559,-0.009790141,-0.029033218,-0.049272988,-0.08407137,0.009887074,0.052471444,0.0821314,0.06286271,-0.041803192,-0.0038528228,0.006571894,0.032977667,-0.032172497,-0.012844884,0.084339954,0.048619144,-0.0012521092,0.062175374,-0.042214002,0.08816729,-0.06638301,-0.009759308,0.017175656,-0.0947237,-0.027531361,0.09621826,0.00026864102,0.03931462,0.047127623,-0.010085288,0.040606618,-0.03065417,-0.04743356,-0.011300081,-0.10249199,0.015028332,0.034884878,0.0274171,-0.010111979,0.07120559,0.042966533,0.04526337,-0.012660339,-0.05188328,-0.06927396,-0.03128829,0.06372542,-0.032196287,0.0021211712,-0.0003075471,-0.017154813,0.051667854,0.0047034,-0.042393297,-0.07139792,-0.049320105,0.0033861154,0.034695093,-0.07275368,-0.11482462,0.0010037493,0.0052839667,-2.341056e-33,0.14524058,-0.09826469,0.014715117,-0.017957631,-0.06179378,0.026428362,-0.024152076,-0.059830077,0.038693495,-0.036853474,0.048562076,0.019924292,0.054905538,-0.12581661,-0.033208255,-0.06809624,0.061262216,0.03725697,-0.020925263,-0.03560875,0.03575867,0.029165152,0.0022347234,0.008985177,0.045207255,-0.0031102297,0.039243933,-0.0019912368,0.013205306,0.047880705,-0.0024443427,0.031524085,-0.039528035,0.012754668,-0.045766834,0.08197233,-0.05894865,0.03627957,-0.011776336,-0.09347458,-0.05408346,0.04081715,0.044464406,0.033512402,0.03971041,0.0924378,0.035438243,0.011446844,-0.008711008,0.036928933,0.02108923,-0.021984892,0.0020067536,0.07106571,0.020234954,0.03918301,0.014634976,0.041980956,0.046798494,-0.023411494,-0.017933616,-0.0014226632,0.011976408,-0.044655852,0.04345836,0.0029047308,-0.016049055,0.044129662,0.08257376,-0.030756999,0.022215372,0.033230327,-0.028224545,0.058559757,-0.036544133,0.014997475,-0.07248902,-0.059109792,-0.037458856,-0.038301364,-0.052015815,0.014467972,0.018739233,-0.028891217,-0.003792105,-0.07407534,0.04982104,0.055766445,-0.046628334,0.07023949,-0.06249343,-0.042317428,-0.006173206,0.025249079,-0.01579769,-3.8130405e-08,0.018781507,0.015298233,0.07162986,-0.14008762,0.048223294,0.056557614,-0.009639946,-0.029926367,0.11044264,-0.086921975,-0.044734932,0.014536343,0.09510662,0.07749317,0.024190292,0.05452409,-0.04197526,-0.025953818,-0.003435974,-0.0563317,-0.037000433,-0.027868712,-0.10011508,0.07683331,0.025236322,-0.02609728,0.0042489897,0.037438825,0.008947812,-0.0648354,0.025897726,-0.007974812,0.09230085,-0.07096351,-0.011423339,0.012581214,0.035177868,-0.00010897028,-0.009807736,-0.0038254664,-0.013059016,-0.11228913,-0.017869124,0.013125956,-0.08102962,0.0103670545,-0.04238284,0.053335875,-0.019573176,-0.0410951,0.08291434,0.023738042,-0.022502555,-0.06044839,-0.023761176,-0.05435963,0.022918409,-0.11194121,0.08278171,-0.023824953,0.0025522676,-0.003262748,0.12748916,-0.023665337 +2.4.2.25,7-O-beta-D-Glucosides of a number of flavonoids and of 4-substituted phenols can act as acceptors.,384,1.0,-0.03688953,-0.096182555,-0.033999827,0.08837209,0.018114826,0.057609364,0.02774439,-0.029833514,0.07812851,0.005647509,0.014485093,0.075841226,-0.118507616,-0.02242395,-0.023710735,0.026983626,-0.0020277505,0.1192585,-0.07985259,0.009728827,-0.032178953,-0.03610152,0.045803964,-0.033071008,0.0074746083,0.009905915,0.02612269,-0.027346956,0.016028311,-0.057829622,0.005399675,0.0065444256,0.08200876,0.06140333,-0.11341112,-0.038880516,0.02365846,-0.0797322,-0.028720481,0.053696197,0.02330016,-0.018936893,0.064917505,0.020103212,-0.03299217,-0.081098676,-0.06683259,0.03230215,0.104385905,-0.03955951,-0.0075770696,-0.025742862,-0.09097514,0.06588812,-0.04519833,0.049300198,-0.06853776,-0.04863083,-0.00898765,0.11583375,0.05579953,-0.043300048,0.013264119,0.010581054,-0.16638868,-0.019249232,-0.060624033,0.00015548241,-0.02891556,0.025140744,0.041457556,-0.0026248556,-0.02998564,-0.004982141,0.047946416,0.077246465,-0.0072111464,0.013471829,0.01305882,-0.058850236,0.084128626,-0.015711814,0.086108424,0.00405886,0.02413068,-0.021391934,-0.06898197,0.06462112,0.023101285,0.074959196,0.019664425,-0.025974242,0.032770466,-0.012487842,-0.014080496,0.013027774,0.13605775,-0.02828408,-0.011286281,0.035058983,-0.026434796,0.008304798,0.00010089099,-0.00925764,-0.046668794,0.023000589,-0.007994881,-0.0025419353,-0.01407791,-0.07105807,-0.009712555,-0.06525091,0.034998924,-0.03935551,-0.080906406,-0.051755015,-0.00018229759,-0.05393085,-0.053170703,-0.044906974,-0.053566866,0.011419096,0.092472084,0.012500684,-0.07913382,-0.022598188,-0.0186536,-3.7415916e-34,0.063384,0.063347735,0.034629826,0.010348023,-0.01696854,-0.017685108,-0.03380984,-0.015305021,0.031457607,-0.04512757,-0.13391964,-0.021702651,0.0004502494,0.021724297,0.107063755,0.035983287,0.03144786,-0.039734602,0.1476342,-0.091345996,0.03482798,-0.023186376,-0.07496163,0.04437541,-0.0052268254,0.03407345,-0.06535171,0.081702285,0.026781378,0.002249038,-0.023778848,-0.033774555,0.02485028,0.036849163,-0.059927676,0.05729622,-0.09369181,-0.06412829,-0.00045558292,-0.060028512,-0.021160858,-0.033616565,-0.04761767,0.04238043,0.011997043,0.023377398,0.0145440195,0.013818365,0.020328443,0.14614931,0.015568887,-0.008492404,0.00885373,0.09434816,-0.034910772,0.06042696,-0.028652713,0.011903825,0.032394085,0.02811811,-0.010765669,0.029746136,0.026343515,-0.029761499,-0.038476065,0.10487806,-0.06381542,-0.051468756,-0.07678671,0.014031894,0.05107974,-0.054291967,0.029485075,0.017663863,0.049586587,-0.045270894,0.01574685,-0.051043857,0.018179953,-0.015233404,-0.04961801,-0.0034957014,-0.0341083,0.12806265,-0.072002284,0.060845118,0.0034039444,-0.03743086,0.072517656,-0.029662486,-0.0516348,-0.03581863,-0.030322438,0.05673768,0.052002624,-4.5934402e-34,0.037769735,-0.0711725,0.013832294,0.056119982,-0.010826769,0.011971282,-0.023369553,-0.093438156,-0.009493852,-0.0035854268,0.030078888,-0.01082266,-0.010041382,-0.033211753,-0.045579907,-0.011046554,-0.029368062,0.052207403,-0.03892642,0.028184185,-0.035639606,-0.009329384,0.034541458,0.05146782,0.07694957,0.0063287057,0.08193073,-0.10293575,0.041038185,0.10407682,0.059104312,0.021652116,-0.027053937,0.014496339,0.06835294,0.016428547,-0.001728592,0.035848618,-0.0017727745,0.06415965,-0.020623757,-0.013379393,0.046939228,0.02061974,0.079989284,0.07133457,0.036214855,0.062222183,-0.034150288,-0.053163115,0.021771519,0.052261665,-0.05257561,0.034099538,0.046947196,0.061794486,0.050790925,-0.038792614,0.030906847,-0.054093532,-0.047986362,-0.12585284,0.08552298,-0.020541366,0.06897243,-0.00513367,-0.015993312,0.13273475,-0.01279618,-0.06471049,0.013819125,-0.10227952,-0.008272298,0.10509619,0.09842285,-0.095765986,-0.060037963,-0.046163335,-0.03707622,0.03801002,-0.058034535,-0.023524582,-0.000670607,-0.05810534,-0.040356647,-0.087129004,0.03330972,0.014745488,0.023784598,0.059617575,0.029189317,0.06851958,0.018116813,0.052657872,0.043132305,-2.5891593e-08,0.024532795,-0.032660823,0.036823723,-0.017411938,0.02002294,-0.013293451,-0.060777597,0.015782963,-0.021167481,0.03689615,-0.06109624,0.07698787,-0.0016211685,0.029351026,-0.020146523,0.037121795,-0.026355248,-0.06481854,0.013288131,0.032830585,-0.038834665,0.0006854553,-0.0089386245,-0.040593155,-0.0018903727,-0.11480233,-0.00899527,0.032748844,0.018228894,0.0047713085,0.07635059,0.03227311,-0.020864693,-0.02175122,-0.03542563,0.02076424,0.0771542,-0.019527256,-0.011145852,0.037592687,-0.08951177,-0.062401965,-0.0065904963,0.045607045,-0.059049718,0.008305156,-0.025229068,0.065904774,-0.0050937957,0.04580563,-0.035206527,0.005186236,-0.020982055,-0.022046687,-0.058469586,-0.0407882,0.015535887,0.0046898513,0.049768623,-0.13101363,-0.068734065,-0.014696548,0.047747925,0.011160641 +2.4.2.26,"Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). ",384,1.0,-0.04170043,-0.045618545,-0.06948145,0.0042109718,-0.03381568,-0.021485157,-0.02055901,0.033379767,-0.015746778,0.0029692366,0.049203865,0.1296205,0.06766264,0.00084477075,-0.11623088,-0.019702384,-0.061757334,-0.018447777,-0.008014465,-0.0014612107,0.11456581,-0.018547827,-0.026982581,-0.04182607,-0.03809175,-0.067839995,0.03071658,0.012873294,-0.0100265145,-0.04748596,-0.06937909,-0.059668794,-0.056061413,-0.038905043,0.05909087,0.07523257,0.025134483,0.014985849,0.05199596,-0.015120437,0.03793406,0.02025892,0.028481016,-0.04021207,0.029603727,-0.121352576,-0.035622377,0.0125791915,0.015063517,0.08438497,-0.016254107,0.011314527,-0.01328173,-0.0004436875,0.058899052,0.014428568,-0.07835071,-0.019710286,0.072176,-0.0103478255,-0.008384248,0.00588634,-0.031187503,-0.051601354,-0.004612705,-0.07618462,0.11231406,0.018403817,-0.04896087,0.054556336,-0.045828436,0.0135540115,0.03893904,0.042597346,0.053999655,0.0491583,-0.06550584,0.02361049,-0.02908635,-0.05587144,0.040043786,0.02041378,0.053886298,0.11601957,-0.06534788,-0.008698632,0.04603157,0.025397526,0.028056132,0.030495085,0.025611483,-0.038441442,0.023842543,-0.06629499,0.013133636,-0.02337278,0.01800666,0.02073233,0.009236614,-0.062404078,-0.016108854,-0.04550387,0.017326195,-0.08594735,-0.011760794,0.04161431,-0.06716944,0.12849243,0.101304404,0.044954386,-0.001863859,0.030445404,0.011526693,-0.060121357,-0.09003784,0.070082374,-0.022139812,-0.039217435,-0.048946854,-0.020514674,0.01708736,0.06758229,0.011659442,0.030865043,-0.015164542,-0.017539086,0.017018933,1.2104721e-33,0.111524805,0.02939922,0.056349926,-0.019952834,0.01590101,-0.011541826,-0.0776074,-0.07078209,-0.040550034,-0.008266008,-0.08030793,-0.02004223,-0.04040336,0.025037292,-0.028681396,0.09723401,0.038611118,-0.057005223,-0.022989385,-0.017709572,-0.025894467,0.09491734,-0.020688325,-0.054496646,0.08445519,0.04122979,-0.04318473,0.036092397,0.023411531,-0.015394616,0.03245127,-0.060114514,0.0065490366,0.018434688,0.11752796,-0.005933332,0.0038840054,-0.037677623,0.059540387,0.040483657,0.080226526,-0.032113045,0.019574992,-0.038218632,0.039885003,-0.00827301,0.050893985,0.05282582,-0.013891043,0.05874053,0.031776346,0.03640292,0.09209109,0.00276974,-0.09547558,0.016130032,-0.013993421,-0.04802592,0.014398971,0.078660786,0.05200556,-0.0026743708,0.02794616,-0.037064392,0.021494105,-0.0061707976,-0.050668005,0.05482051,-0.031680603,-0.0028319706,-0.056589402,-0.08653754,0.08587389,0.0789892,0.01710774,0.010723962,-0.033365205,0.066162474,-0.04382634,-0.017660819,-0.07258846,0.013320249,-0.09981752,-0.033581227,-0.022325877,0.07363235,-0.055772197,-0.09809286,0.013548523,0.07812225,-0.056392662,-0.02512853,-0.058496475,0.031510785,-0.069499284,-5.2756304e-33,0.022860441,-0.043821175,0.07865492,-0.006970795,-0.071307324,0.014277271,-0.010333744,0.027637823,0.0011786437,0.029643588,0.00038915421,0.034999706,0.028362,-0.052503426,-0.0044032773,0.086142845,-0.017826682,0.1157816,-0.029683106,-0.031583115,-0.0030754232,0.06461566,-0.024915807,0.03859577,0.051192842,0.026532022,0.048134953,0.045717414,0.020105224,0.11344591,-0.0013795021,-0.018914565,-0.07567767,-0.091659755,-0.06748821,0.030753136,-0.048334733,-0.044267815,0.015747936,-0.026793212,-0.0066062887,-0.019509856,0.04956803,0.039300587,0.078982644,0.06289824,-0.039536104,0.043695174,-0.00045156112,-0.031616885,0.007998456,0.06424179,0.009629069,0.03388526,0.016764551,0.04403547,0.0012438318,0.08815518,0.052443825,0.0089745335,-0.06806996,-0.02547017,-0.01535776,-0.04632731,0.036548525,0.047977794,-0.0057168053,-0.08083352,0.03982689,-0.03497785,-0.034167234,-0.018627768,0.03962607,0.015953664,0.030875,0.059219856,-0.10747818,-0.09532097,-0.041143544,-0.0026495517,-0.0004374899,0.0012552885,0.03537387,-0.07323032,0.0017343475,0.00035619937,0.041211262,0.055706553,-0.00467722,-0.0053446577,0.0316713,-0.03592408,-0.056235578,-0.005811744,-0.08001676,-3.045192e-08,0.07046892,-0.028348463,0.029052932,-0.09763766,-0.07342345,0.007010766,-0.033994853,0.059320606,-0.012848294,-0.008423409,-0.013158674,0.018387776,-0.049046878,-0.07687835,-0.052608654,0.062324665,-0.023692224,0.0071283705,-0.06091015,0.00041925398,-0.12670185,-0.031376682,-0.09464017,0.14811395,0.0171984,-0.08601593,0.03596439,-0.013480645,-0.06625826,-0.027322954,0.021468747,-0.020328501,-0.09279271,-0.048272844,-0.05405219,0.0067724455,-0.040716596,-0.019605499,0.09814091,-0.028642436,0.011862769,-0.020764448,-0.03887432,0.03744706,-0.058195453,-0.005209636,0.002364723,0.044048093,-0.06169293,0.056003343,-0.034683876,-0.04292402,-0.011014497,-0.13255651,-0.05076529,-0.07289307,0.048862536,-0.03448526,0.028753804,0.0456739,-0.08035466,0.0074881944,0.1741167,-0.048665825 +2.4.2.28,Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy groups. ,384,1.0,-0.095388494,-0.10628016,0.031208219,0.024410866,0.0046096,-0.007915195,-0.01962946,0.05359023,0.03945641,0.007809375,0.10970138,-0.0007540858,-0.08921819,0.054592784,0.015132903,0.07782527,-0.0896855,0.0709411,-0.06681269,0.028488927,0.03622725,-0.022463888,-0.013222174,0.04301642,-0.0061828163,0.03940011,0.007907956,0.053739756,0.03173391,-0.11524053,0.03814921,0.06314123,-0.04040857,-0.043845776,-0.03106098,0.04978192,-0.0673191,-0.004597115,0.047902465,0.029666994,0.043983307,-0.015366405,0.009453998,0.015640186,-0.008701815,-0.049251996,-0.059045706,0.028029224,0.03587984,-0.016490579,-0.01021564,-0.02101364,-0.04570449,0.08147687,-0.05423242,-0.03152563,-0.10979823,0.00014087324,0.020675445,-0.027238492,0.07525874,-0.019837828,-0.03228384,0.028270196,-0.06253924,0.06620246,0.056913644,-0.054410893,-0.062256142,0.004790155,-0.02732281,-0.04477796,-0.011220184,0.009628029,-0.018514728,0.03883383,-0.0671937,-0.0613241,0.023591992,0.01552803,-0.051983528,0.042696424,0.016001761,0.063671276,0.007519055,0.04340249,-0.018307393,-0.014715774,-0.055120055,-0.05127878,0.008558109,-0.0150521565,-0.0986188,-0.0012035408,-0.06676238,-0.033930477,0.003494249,0.1060394,-0.035569914,0.0002864171,0.022204304,0.0031512317,-0.075535506,-0.03299796,-0.026753753,-0.039288323,0.0900617,-0.02072121,0.011020133,-0.025891019,-0.0615766,-0.0585261,0.04489339,-0.01762948,-0.028254164,0.0042682374,0.015379663,-0.0005930945,0.040392272,-0.058578886,0.06278197,0.005212872,0.018795213,0.021378778,-0.06387192,0.09175075,-0.0642715,1.1732699e-33,0.045620956,0.040871494,0.09282734,0.08961954,0.054129746,-0.034568515,-0.13397346,0.04295158,-0.043512005,0.0037822914,-0.12001432,0.021722142,0.10836097,0.00040052613,-0.023480302,-0.0054342663,-0.032239173,-0.016610365,-0.0039159786,-0.04316531,0.01829094,0.08197748,-0.07826539,0.027160924,-0.042241227,0.044234846,-0.02719369,0.033155665,0.022511931,0.016582077,-0.07757192,-0.030416457,-0.05815796,-0.0033092403,0.058514,0.10155517,-0.036086854,-0.0153599,-0.0067968797,0.012343136,0.059765693,-0.017062599,-0.07198572,-0.006511369,0.10920615,0.015544615,-0.052159306,0.04378587,-0.026729789,0.010984766,0.070759386,0.0113115655,0.033127896,-0.05074442,0.023922086,-0.0073032873,0.021792414,-0.0013270006,0.04671826,0.12726793,0.01676527,0.056231055,-0.010000334,-0.027743042,0.008016344,0.07582828,-0.036371246,-0.046939235,-0.0069969078,0.037229527,-0.021873534,0.022141386,0.07147725,0.098897085,0.040669497,0.00018053722,-0.021658687,-0.025372664,0.07476676,0.076045096,-0.050233755,-0.12603317,0.013525389,-0.08564302,-0.04592214,-0.052915636,0.011068309,-0.08292687,-0.0407728,0.0007836626,0.049228035,-0.07717148,-0.017808778,-0.03972333,-0.029657608,-3.1438953e-33,-0.001577028,-0.099647984,-0.017213335,-0.030976977,0.0018911915,0.09817622,0.023355575,0.02383432,0.034684528,0.008136836,0.114865236,0.06059135,-0.0046123723,-0.0050075953,0.04299037,0.043240618,-0.017582994,-0.014190338,0.025265476,-0.0072352174,0.09155654,0.07764832,0.017297944,0.08502899,0.020238418,0.069529586,0.01115355,-0.027157964,0.04147993,0.06890972,-0.05376934,-0.04723896,-0.046164833,-0.013940799,-0.020136124,0.06012792,-0.04535848,0.08007322,-0.07684197,-0.07441478,-0.0958954,-0.002467656,0.106454365,0.13516916,0.030208109,0.011515095,-0.006096745,-0.022571437,-0.083659485,0.022684759,-0.04058917,0.008909458,-0.08979613,0.0036190737,-0.005862987,0.010859618,-0.00604263,-0.08025032,-0.036673702,-0.024592135,-0.031798795,-0.057234358,0.039487023,-0.047851503,0.011655989,0.053682424,-0.01932212,0.031006422,0.009228063,-0.04539647,0.028126817,-0.0020033398,-0.0011616531,-0.029775936,-0.08625663,-0.06656901,0.037848085,-0.022275189,-0.02475693,-0.002484289,-0.07160907,-0.01340762,0.019884564,-0.03817695,-0.030603707,-0.075926326,0.0033623404,0.0785229,0.030321293,0.10011171,-0.020425228,0.0523765,-0.048734672,0.05919817,0.09418588,-2.5209589e-08,0.03288516,0.0060579097,0.06446836,-0.07859926,-0.012766202,0.03121948,-0.018472137,0.035317358,0.06360772,-0.0009341568,0.0495891,0.10113348,0.014349012,0.078553386,0.05022419,0.013955018,-0.05440157,0.01662047,-0.02596489,-0.007917304,-0.060536027,-0.026814418,0.058019362,-0.040236957,-0.0059709055,-0.100244425,-0.0040005343,-0.048939683,-0.010730456,-0.07135264,0.03985769,0.044793066,-0.023075439,-0.018932724,-0.050988294,0.0294022,-0.045877617,-0.0147027895,-0.076115966,0.08677481,-0.06115405,-0.11728062,-0.037705548,0.053862013,0.02058771,0.021463908,0.000457923,-0.004578822,0.004439306,0.050112113,0.009337878,-0.0021417735,-0.030984355,-0.030933777,-0.13586707,0.044522,-0.036035776,0.03564763,0.024716802,-0.073376246,-0.036528956,0.022298774,0.14187038,0.029395957 +2.4.2.29,"Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eubacteria, which produce queuine de novo, the enzyme catalyses the exchange of guanine with the queuine precursor preQ1, which is ultimately modified to queuosine [5]. The enzyme can also use an earlier intermediate, preQ0, to replace guanine in unmodified tRNATyr and tRNAAsn [1]. This enzyme acts after EC 1.7.1.13, preQ1 synthase, in the queuine-biosynthesis pathway. cf. EC 2.4.2.64, tRNA-guanosine34 queuine transglycosylase.",384,1.0,-0.13573405,-0.080637515,-0.10718078,-0.0066954354,-0.04525101,0.014705035,0.04920702,0.038189076,0.033185076,0.03721952,0.056893278,0.00413387,-0.09654522,0.016256297,-0.04845456,0.02479387,-0.088611916,-0.0066141887,0.041378714,-0.028968325,0.050078083,0.059294287,-0.066520505,-0.033836413,0.051656708,-0.03474988,0.02268513,-0.055695903,0.01830821,-0.068227574,-0.03441464,-0.050926033,0.035649877,0.011416883,0.008322236,0.045784008,-0.03910651,-0.09254478,0.09177482,0.030751847,0.09198547,-0.005217553,-0.023764843,-0.03959341,0.021584991,0.05386132,0.058769442,0.08449833,-0.027091382,-0.015744362,-0.072528355,-0.05022243,-0.049817633,-0.003941494,0.030218018,0.020783503,-0.015125997,-0.0062322603,0.05576846,0.0027820622,0.068349175,0.020973245,0.061154295,-0.046561833,0.005102565,-0.07518759,0.062076077,-0.006787915,0.041704383,-0.005847626,-0.07863741,0.015511943,-0.028491972,0.077544846,-0.0714613,0.15415743,-0.024142131,0.012643613,-0.046138305,0.041759707,0.031880442,-0.06464837,0.020827912,0.038628522,0.05128896,-0.054988485,-0.003272429,0.027777774,0.07751873,0.052682593,0.097484045,0.02796364,0.042580873,-0.062464796,-0.054296765,0.069320254,0.01732519,0.011188551,0.063550524,-0.04652089,-0.01386247,-0.009670902,0.052098047,-0.0063493894,-0.052010246,0.01645331,0.07578019,0.0005548722,0.03677208,0.016928663,-0.057581592,-0.024255155,0.025413617,-0.037220545,-0.03599389,0.05854648,0.043728814,0.01586488,0.0047948197,0.008177637,-0.0069264364,0.08542379,0.05819726,0.02446944,-0.048629478,0.043622646,-0.09704036,4.505554e-33,0.06857035,0.05062519,-0.003020497,-0.024676312,0.04919666,0.003503805,-0.08445822,0.03883842,-0.056856655,-0.0020079922,-0.09553511,-0.064082064,0.004251213,-0.010358307,-0.022096839,0.045016274,-0.043736346,-0.04511637,0.058189325,-0.012237426,-0.0065613,-0.016951846,-0.06558157,0.030856399,0.004923745,0.0433387,-0.0018631403,0.014682919,-0.01871535,-0.041491095,-0.051838018,-0.091541685,-0.04828507,-0.029501813,0.060856458,-0.048781764,0.021711772,-0.015915986,-0.05512088,0.036156334,0.046838026,-0.025694901,0.012494471,-0.008853316,-0.0035229588,-0.02130359,-0.05619958,0.008060686,0.071902625,-0.052295733,0.00029078155,-0.031403292,0.010700161,0.0095761325,0.0060731303,-0.022608835,-0.002192328,0.014657442,0.09133388,-0.008554781,0.033564534,0.019319087,-0.0009974964,-0.014848264,-0.044996798,0.027978422,-0.081390604,-0.029941544,0.0105204685,0.027679276,-0.037791956,-0.11393661,0.08487751,-0.014160843,0.059143562,-0.048317418,-0.0707362,-0.01630513,0.007023173,-0.017625045,-0.04184136,-0.036363535,0.0146751385,-0.0046145623,-0.03131934,-0.013388466,0.01893598,-0.0012237276,0.041253783,0.048432805,0.0129254535,-0.051877383,-0.056625567,0.037251975,0.033373617,-3.93511e-33,0.053595692,-0.058686085,0.008044823,-0.023671873,-0.09772729,0.044429366,0.015367215,-0.098049596,0.0041599674,-0.060172107,0.07668699,-0.02186652,0.06558331,-0.05889876,0.031067524,-0.02623429,0.026872706,-0.0005432923,-0.061912775,-0.05565644,0.0025428827,0.017050749,-0.014071146,-0.029007513,0.02872308,0.036991484,0.05780885,0.074096136,-0.0049646324,0.08318688,-0.11188321,-0.059404,0.00896633,0.028946746,-0.07806112,0.0065224785,-0.010682438,-0.0064680683,0.038713925,-0.041146405,0.05133686,-0.045295205,0.043921903,0.13465244,0.018231379,0.06973914,0.0102371685,-0.03914012,-0.024880132,-0.049621057,0.118569285,0.09238611,0.0044991,0.025838906,0.016508307,0.029281488,-0.014689954,-0.018763732,0.0225974,-0.02560982,-0.0003165438,-0.109549396,0.03503051,-0.09188032,0.0838978,0.06336023,-0.040272057,0.15669,0.05112881,-0.058383618,-0.0012289665,-0.010317662,0.027533822,0.01481286,-4.598633e-05,0.022402002,-0.06284849,-0.051086765,0.053268366,-0.07487425,-0.054610774,-0.02766007,-0.048837986,-0.06800496,0.016901838,-0.014084177,0.02035581,0.08314088,0.023884026,0.0622871,-0.06462022,-0.02963472,-0.02467983,0.06708699,0.0406201,-3.984517e-08,-0.06832848,0.021911278,-0.005120206,0.03945552,0.0907349,0.032146424,-0.068629265,0.08726356,0.05715494,-0.032178383,-0.054981057,0.06303901,0.041821156,0.06922216,0.09811123,0.06855688,-0.09339461,-0.011125838,0.00055423204,-0.056975834,-0.063794486,0.042057615,-0.14243335,-0.024829378,-0.042110503,-0.03545819,0.045458365,0.067280896,-0.008994074,-0.041112855,-0.042195357,0.012649445,0.00079111516,0.04744469,-0.027852267,0.0086555295,-0.015068856,-0.037459668,-0.023030771,-0.0024675126,-0.011781304,0.009754692,-0.14351799,0.036178976,-0.08943172,0.028774235,0.028005872,0.06754122,-0.0647109,0.021394977,0.08698762,0.016210476,0.05487113,0.012339437,-0.052334517,-0.0051217093,0.034803037,-0.016500557,-0.106514245,0.06323858,-0.03595703,-0.052911475,0.15063462,-0.006400334 +2.4.2.64,"Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes and a small number of prokaryotes queuine is salvaged and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. cf. EC 2.4.2.29, tRNA-guanosine34 preQ1 transglycosylase.",384,1.0,-0.09224857,-0.085682824,-0.10155955,-0.03374441,-0.012841644,-0.02579812,0.070394315,0.028501578,0.0059447438,0.057081416,0.07497181,0.010374978,-0.11372947,0.0235236,-0.02288018,0.014638756,-0.073767275,0.04315197,0.052656777,0.0053666523,0.0015586796,0.07655334,-0.061310925,-0.0102087,0.038568456,-0.04882796,0.008680712,-0.047925845,0.016944487,-0.10831406,-0.069040045,-0.031855248,0.07888978,0.0039513116,-0.007302284,0.010434195,-0.08122747,-0.078405395,0.09157486,-0.024998637,0.100346036,0.0033113037,0.03361718,-0.018878639,-0.007403993,0.065710515,0.03066148,0.05655485,-0.009157811,-0.0251875,-0.027799983,-0.06850713,-0.10118816,0.06277393,0.023880063,0.03460209,-0.019571986,-0.024213687,0.06869264,0.0237101,0.052670408,0.04938292,0.04625773,-0.05409232,0.0066538127,-0.09984937,0.08163927,0.019104734,0.02554589,0.0050555705,0.013349571,0.01252957,-0.02436692,0.05843635,-0.070726104,0.139402,0.0045050294,-0.011143623,-0.06595273,0.063263185,0.003911045,-0.045257248,0.06533391,0.035833538,0.022043644,-0.076734684,-0.021410262,0.0410214,0.03914336,0.010407853,0.08099847,0.05925768,0.043410648,-0.06332787,-0.0765751,0.051824998,0.060492735,0.015157017,0.07656686,-0.033209544,0.009852484,0.0009189871,0.034054976,-0.04209221,-0.0665732,0.042431384,0.035157096,0.002579011,-0.00026505927,0.030387746,-0.06830586,-0.011040144,-0.00057588465,-0.03576634,-0.036310937,-0.0050015277,0.033367272,0.006322618,0.009897677,-0.020794554,-0.0047534322,0.09909185,0.060125448,0.008899394,-0.08870299,0.02865903,-0.08472351,4.0642258e-33,0.03401559,0.05727785,-0.032200973,0.004038534,0.03345204,-0.016976407,-0.030870216,-0.0024875826,-0.05119694,-0.009774219,-0.12009251,-0.043177135,0.024941184,0.0036026738,-0.030038752,-0.0007354589,-0.051010378,-0.029492524,0.046560463,-0.008316947,-0.021561934,0.062250543,-0.086096875,0.0053636935,0.04305232,0.0111211315,0.011981973,-0.016750002,-0.034513146,-0.03911828,-0.04322596,-0.056907568,-0.06491001,0.00061604567,0.08998745,-0.045354262,0.039001226,-0.029181993,-0.08057001,-0.010374598,0.05045222,-0.0027767,-0.014566734,-0.030867925,-0.0003869886,-0.0027650814,-0.053306717,0.0183037,0.048418626,-0.060368296,-0.009306248,-0.017999593,-0.013904031,0.011054094,-0.025834015,-0.01574343,0.012555951,0.004344243,0.11534475,0.024811035,0.011840677,0.027674355,-0.004333825,9.935335e-05,0.0019324004,0.0633963,-0.101477616,-0.06861408,-0.0069501526,0.00465891,-0.037243906,-0.12152939,0.111287,-0.017182177,0.00050139613,-0.070308626,-0.041338257,-0.0045800097,-0.042904742,0.018493405,-0.009905654,-0.05771469,0.012662903,-0.032116663,-0.002891662,-0.019755207,0.0127046015,-0.018924609,0.01423391,0.0699811,0.033856075,-0.049131628,-0.03049256,0.034229368,0.051396955,-3.723836e-33,0.07182284,-0.042490266,-0.004089854,-0.019467313,-0.115878195,0.037171796,0.028655961,-0.07345925,-0.014041295,-0.053813826,0.053476978,-0.0022233624,0.050501734,-0.060762852,0.014157942,-0.041607525,0.02479155,0.009291675,-0.07565622,-0.069935374,-0.01678012,0.046753652,-0.014280211,0.004533937,0.061118208,0.014765962,0.03550253,0.089233786,-0.0043691243,0.061147694,-0.09789761,-0.08344584,-0.005411976,0.072808474,-0.06883164,-0.004948317,0.0052714963,0.009447093,0.0325205,0.014090136,0.03857546,-0.018138697,0.03554527,0.16168019,0.005442384,0.051469997,-0.0116651105,-0.028347813,-0.0072509996,-0.080050185,0.12449523,0.04514075,0.0084695,-0.008806471,0.047485635,0.032674167,0.003204659,-0.0056048,0.02677681,-0.058665972,0.012685675,-0.10417765,0.025648024,-0.121199794,0.09281894,0.06011589,-0.051992748,0.06256706,0.032093428,-0.05335051,-0.036931545,-0.016301572,0.025721919,0.02423224,0.027327428,0.009788795,-0.049223118,-0.02453334,0.036073577,-0.047419697,-0.00018348335,-0.041896947,-0.00268781,-0.056820393,0.07045323,-0.023749512,-0.02918091,0.11509693,0.029617306,0.03577321,-0.040904444,-0.022735935,0.023557734,0.07783163,0.07009017,-3.4586563e-08,-0.027870493,0.046157997,-0.012703507,0.04004964,0.05580587,0.042859558,-0.026033217,0.06351686,0.056963336,0.0012653368,-0.06513622,0.082624674,0.031435065,0.07938212,0.08596916,0.07175387,-0.09126008,0.011413562,-0.012333976,-0.040229578,-0.070987806,0.04572576,-0.11130991,0.017296232,-0.09107175,0.0021863666,0.06940956,0.069725536,-0.019159192,-0.022280606,-0.032140404,-0.0022439759,-0.012318732,0.022470636,0.025034016,0.016690109,0.012100081,-0.024767132,-0.01729041,0.007983027,-0.022617156,-0.005462882,-0.15109016,0.04676694,-0.06754552,0.010645309,-0.01913531,0.094451174,-0.088189475,0.010724726,0.11113365,0.025831845,0.022311773,-0.00057455036,-0.04818911,-0.0001828837,0.032722767,0.00034769357,-0.11543745,0.0507305,-0.033927973,-0.041953113,0.13399477,-0.035097335 +2.4.2.30,"The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20--30 units.",384,1.0,-0.027406542,-0.025639005,-0.024680324,-0.057560094,-0.01368826,0.026946586,-0.019845305,0.014395914,0.030931722,0.055358287,0.057028838,0.0719417,-0.07147652,0.037554618,-0.017437525,0.06844392,-0.07986626,0.055898484,0.0048329164,0.008310875,0.043566965,-0.00041006136,0.06880542,-0.05084822,0.056996778,0.012753406,0.012283925,0.016749203,-0.0037357912,-0.09536827,-0.04084385,-0.019057559,0.017599324,-0.048568886,0.016927296,0.08930771,-0.019525183,0.010301245,-0.0026327348,0.017432816,0.07224978,0.027094936,-0.0020519202,0.015045437,-0.046074808,-0.05334547,-0.06634076,0.090815865,0.041995026,-0.017674183,0.02133334,-0.02212375,-0.024770593,-0.023890238,-0.031808812,0.10372896,0.0032524967,-0.05642766,-0.015612362,-0.07185294,0.056352135,-0.05532666,-0.03870472,0.0584679,0.07209639,-0.039736297,0.09602091,0.016281977,-0.017042672,0.042518273,-0.08602565,0.026493851,-0.022681044,0.033408757,0.09821225,-0.074796155,-0.068855405,-0.037708547,0.06638737,-0.018562363,0.02773726,0.009047972,0.007220216,0.031981513,0.056934334,0.07155813,0.024409605,0.06867989,-0.048391223,0.008481688,-0.018121112,-0.039188452,-0.031104216,-0.020150648,-0.06343816,-0.030271374,0.06300078,0.0368677,0.01855099,-0.017224953,0.06105314,0.066196404,-0.02352884,-0.04905761,-0.023805501,0.01571196,-0.06849593,0.03713458,-0.024415547,0.051452782,-0.031516757,0.030784378,0.028681915,-0.07342064,-0.020262567,0.08852395,-0.086883776,-0.025581907,0.007614996,-0.05336899,0.00083435746,0.00414608,-0.015835857,0.08307314,-0.0019981216,0.028057862,-0.061212268,-6.910545e-34,0.07210113,0.04925107,0.03342146,0.05255407,0.0218876,-0.0039854166,-0.08327591,0.0003440252,-0.035290807,-0.00011971091,-0.1330954,-0.087227084,0.047635052,0.06900527,-0.02678894,-0.037369944,-0.024849335,0.008155065,0.0018485059,-0.019167725,-0.010762456,0.09867285,-0.012053489,0.095652714,0.03793772,-0.017185448,-0.12018871,0.061931457,0.0063827625,-0.017778527,-0.0013666939,-0.033099245,-0.10300031,0.07191988,-0.0076335766,-0.008779061,-0.047115684,-0.082068615,0.10588278,0.0454262,-0.02495755,0.006588432,0.045967016,-0.039992284,-0.007970282,-0.042989004,0.03174401,-0.015587106,-0.02577935,0.09343131,0.033875532,-0.038426396,0.03467912,-0.08768079,-0.03466101,-0.0057411743,-0.03821101,-0.01517769,-0.0020060705,0.09722617,0.044376507,0.044993345,0.025657434,0.03900123,-0.047975145,0.051239938,-0.090287,-0.080165096,0.059613895,0.043029007,0.01491748,0.018830577,0.014207239,0.025982583,0.009936541,0.0006739209,-0.059391577,-0.067735806,-0.026152538,0.075597964,-0.06804913,-0.022142801,-0.11476971,-0.054931663,0.004336029,-0.022007799,0.038953446,-0.112298176,0.0008687767,0.05088107,0.0022259234,-0.071579866,-0.0104099875,0.00020069351,0.12030233,-3.102209e-33,0.090164304,-0.009184872,0.11519686,-0.035759818,-0.062122338,0.035209797,0.058272358,0.014641177,0.027226929,-0.0008050683,0.04055747,0.082058534,0.019232076,-0.026735593,-0.024288388,0.00078495406,-0.038082954,0.022599801,0.017263496,-0.03352812,0.012675353,0.071275614,0.032674506,0.08222916,0.009217561,-0.060874693,-0.03288681,-0.041991804,0.074627556,0.02066082,-0.0067895837,-0.03397842,-0.084869556,0.08025256,0.009429844,0.058266077,-0.05186515,0.047704753,-0.008317144,0.05562157,-0.03564823,0.028096363,-0.039781813,0.025495678,0.06895779,0.050389268,-0.04777764,-0.047431283,-0.008132341,-0.12288394,0.008103009,0.06918553,0.026763482,-4.182948e-05,0.05380409,0.085161574,0.019706149,0.016364003,0.03952238,-0.044724863,-0.08360204,-0.044177942,-0.0052248933,-0.05881844,-0.020883566,0.015997346,0.0023345195,-0.03549816,-0.02245195,-0.056073353,0.03217397,0.033042062,-0.0020921314,0.052009273,-0.012489657,-0.10300293,-0.051315315,-0.05184107,-0.054856155,-0.05530571,-0.075601876,-0.014481625,0.017741943,-0.011065075,-0.031716056,-0.04760931,0.085362434,0.012520056,-0.0552699,0.020747634,0.04403991,0.10031455,0.032393787,0.023478243,0.008151298,-3.7827476e-08,0.05479498,-0.017233536,0.045555983,-0.14474957,0.024121411,0.059982885,0.026567772,-6.0709972e-05,0.0116770165,-0.022185275,-0.011961287,0.17928784,-0.004156238,0.06305133,-0.015611491,0.025573196,-0.10329416,-0.03713301,-0.032994803,-0.13147944,-0.07614088,0.041862868,-0.06753343,0.06461536,-0.06288312,0.0149593195,0.05312454,0.001629691,0.035432667,-0.04023614,0.05263644,-0.005201645,-0.03728565,-0.009031953,-0.0075772344,0.010035093,-0.011765143,-0.009443329,-0.00011197395,0.038363017,0.008941325,-0.12524885,-0.03965047,0.021135727,0.011930196,0.012456671,-0.029625125,0.0050988393,-0.08126917,0.03336941,0.11808398,0.0029265583,-0.036957804,-0.07022894,-0.058009025,-0.015979232,-0.06988516,-0.043407645,-0.0013120591,-0.06201375,-0.040304977,0.004588007,0.07632513,-0.0891071 +2.4.2.31,"Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities [4]. Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly [1,5]. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymic activities. (cf. EC 2.4.2.36 NAD+---diphthamide ADP-ribosyltransferase).",384,1.0,-0.03290234,-0.06427027,-0.04011512,-0.038664933,0.050179295,0.05998142,-0.01951271,0.02477845,0.066010274,0.051465444,0.012257819,0.029184708,-0.027118,0.14640728,-0.017477496,0.025771387,-0.06643467,-0.003991585,0.05530358,-0.0055055763,-0.006679673,0.07654639,-0.09826939,-0.05386799,0.045006767,-0.04856923,-0.0019232827,-0.0043189363,-0.0281699,-0.061356492,-0.046695795,-0.06691323,0.06718358,-0.031504326,0.045252744,0.07914072,-0.0063775484,-0.030142004,0.028548462,0.010641457,0.02005093,0.062176663,-0.061315693,-0.036170743,0.024286605,-0.014596192,0.06488337,0.050307855,0.06131751,-0.0360492,-0.013190365,0.045234643,0.008803455,-0.029107232,-0.0009805007,-0.015375615,-0.059042204,-0.09047614,-0.012154502,-0.044717558,-0.040530354,-0.0608246,0.014005399,-0.012793586,0.03703432,-0.039215345,0.089426704,-0.017005758,0.0015342344,-0.002863937,-0.06290467,-0.028388482,-0.04348775,0.046127073,-0.037124686,0.02451555,-0.05087769,-0.026765043,0.08176745,0.002823867,0.04256233,0.026624165,-0.019116165,0.05874498,0.049812052,-0.028640555,0.004491557,0.05736683,0.025525363,0.032070596,0.027644372,-0.041641753,0.03766023,0.004930991,-0.03141986,-0.050216515,0.013693325,-0.016037893,0.00055491336,-0.036651954,0.0034096946,0.08037524,-0.036362812,-0.054845028,0.06315201,0.017827021,0.034736954,0.08554069,-0.042313457,0.028656418,-0.009328732,0.030677665,0.016851269,-0.028180419,-0.0007756412,0.08168168,0.013241096,-0.11152284,-0.073711775,-0.013170009,-0.043868337,0.006446393,0.068880305,0.076064005,-0.007962332,0.06804154,-0.10300921,3.6831742e-33,0.03702376,0.018796843,0.03476851,-0.014426506,0.06538896,0.02336994,-0.086343646,0.04770034,0.047912996,-0.019596105,-0.068967305,-0.11497821,0.124157004,0.036159217,-0.0057697655,0.034748945,-0.037911147,-0.01834496,0.033229396,-0.0028504147,-0.025521643,0.020103313,0.0025047997,0.06589505,0.029450187,0.003098631,-0.054159172,0.00046657445,0.018356014,-0.018576724,-0.050741255,-0.10417555,-0.10516547,0.008186002,0.060533315,-0.03965214,-0.005582138,-0.044732165,0.041666593,0.023564493,-0.08659334,0.015242206,-0.07813011,-0.037658665,0.062606044,-0.069799125,-0.0906872,0.07339351,-0.0433563,0.024986237,0.093527205,-0.059945233,0.03447458,-0.09732502,-0.06566954,0.008232107,-0.025931628,-0.025017321,0.030973537,0.044994954,0.01560946,-0.014795498,-0.024044385,0.051981516,-0.04558402,0.050444704,-0.04811612,-0.11286359,0.035369854,0.0637616,-0.05127185,-0.03507801,0.050001934,0.02068066,-0.0106151095,-0.060133584,-0.048626304,0.02090519,0.06945469,0.06491541,-0.055310052,-0.023933224,0.0074084196,0.05210578,0.009220826,-0.008428204,0.091683276,-0.015276386,0.08589944,0.007878137,0.09499318,-0.016363364,-0.09772704,0.059583165,0.021211356,-4.647233e-33,0.12289208,-0.08003616,0.038962066,-0.12995717,-0.050205696,0.11720182,0.053779088,0.0029359434,0.10599832,-0.12284953,0.08450979,0.04269609,0.036935747,0.015019784,0.006878773,-0.055698868,-0.034769952,0.078962944,-0.033820134,0.0041303667,-0.029571889,0.011701775,0.012136258,-0.008113912,0.049225833,-0.003309977,-0.08502299,0.04873215,-0.015732553,0.0723226,-0.02312303,0.059656426,-0.06401712,-0.013856349,0.05152086,0.05027372,-0.022144377,0.040561683,-0.054183442,-0.021275276,0.00016260358,0.07680222,0.0075135846,0.07707157,0.046508722,0.08093955,-0.020895138,-0.033070296,-0.052033044,-0.07285982,0.07100854,-0.01710739,0.020915529,0.0447625,0.0058850404,-0.01216963,0.04692419,-0.012683841,0.017716069,0.029108863,-0.060381807,-0.09356939,-0.0042636734,0.0015040233,0.0781107,0.027648997,-0.0014078,0.019446548,0.010203722,-0.097047724,0.06421047,0.020965204,0.038303543,0.02338891,0.0063889786,-0.0022554097,-0.09031419,-0.016712107,0.0033137999,-0.058361664,-0.034685533,0.0050759353,-0.05815489,-0.007416152,-0.07064002,-0.010947422,0.023698203,0.09580129,-0.0064881174,0.03846502,-0.07440562,0.04080998,-0.067822546,0.026784537,0.021201322,-5.5283433e-08,0.052844886,0.040265456,0.0076004136,-0.0741639,-0.044213817,0.06883487,-0.035844002,0.013456165,0.060849927,-0.026214179,0.06418625,0.12874503,-0.007853567,-0.016947845,-0.034510065,-0.004979586,-0.08231014,-0.024043374,0.00935196,-0.017408388,-0.07118695,0.050993074,-0.079962924,0.0044987067,0.019074328,-0.059848614,0.013756979,0.010417835,0.051720377,-0.09338538,0.03011484,0.0002172957,0.034838106,0.0027944478,-0.05257417,0.007300723,0.01678471,-0.064756036,0.03683149,0.057590563,-0.036709134,-0.03528515,-0.090241715,-0.0673386,-0.011021458,0.06716321,0.01844461,-0.01254364,-0.06883889,-0.037738618,0.0707637,0.011013606,0.029395588,-0.053616107,-0.06538289,-0.0062292092,-0.077597275,-0.12474201,0.053817607,-0.0006483636,-0.021559615,-0.018116591,0.11204383,-0.006650102 +2.4.2.34,"The position of acylation is indeterminate because of the ease of acyl transfer between hydroxy groups. For a diagram showing the biosynthesis of UDP-L-arabinose, click here.",384,1.0,-0.057943247,-0.09880719,-0.019767605,-0.04871502,0.010491267,0.036799703,-0.03951796,-0.009263553,0.044983875,0.012633664,0.1420696,-0.023712222,-0.015609417,-0.031339098,-0.038666606,0.03452427,-0.008708537,-0.01982917,-0.061271507,-0.051210262,0.03987605,-0.005325874,0.006725419,-0.008624551,0.07130713,-0.071314126,0.015695386,-0.018844182,-0.0013208368,-0.126319,-0.017533641,0.017605048,-0.02165127,-0.03784547,0.078832775,0.10153442,-0.036368195,-0.11355686,0.13014734,0.029566428,0.0866965,-0.015022763,0.05207791,-0.03512271,-0.031526376,0.008990678,-0.00527493,0.060024098,0.026124861,0.006722791,-0.033727717,-0.042071488,0.019607792,-0.024642644,-0.09625961,-0.04575111,-0.027546601,-0.007352658,-0.03806918,-0.03871861,-0.0063745184,0.030285949,-0.023410814,0.016885566,-0.06861812,-0.047173228,0.09908018,-0.09407955,-0.008154022,0.0778543,-0.0376845,-0.029218255,-0.021688389,0.039486207,0.08119588,-0.03758326,-0.033271696,-0.054651737,0.019978542,-0.021789685,0.05309536,-0.039843787,0.028629718,0.0017394648,-0.009612364,-0.0907835,0.03145592,-0.0043293526,0.016297843,0.05590434,0.031078557,0.008437525,-0.03508568,0.009498024,-0.028807871,-0.009132174,0.02356185,0.043687314,-0.012414086,-0.0175765,-0.037892867,-0.005618955,-0.049351137,-0.048417307,-0.07741095,-0.064388044,-0.082392484,0.055095896,-0.007514507,-0.0015155846,-0.031597152,-0.010448867,0.030196758,0.025217332,-0.08475158,0.039582036,0.00513191,-0.12501629,-0.021769438,-0.11400133,-0.0026606522,-0.063053295,-0.0077134618,0.075820714,-0.046453968,0.026390357,-0.11233022,7.6683287e-34,0.04336982,-0.018707387,-0.008377281,-0.07198906,-0.017185485,0.009639147,-0.041934494,0.024227811,-0.048657335,-0.055359673,-0.052680016,-0.07684876,0.02399927,0.04685123,-0.052137233,-0.020645672,0.06666345,0.035302173,-0.05166396,0.012541598,-0.0007750824,0.10865291,-0.030385762,-0.03146809,-0.040192705,0.03680199,-0.01620565,0.015467913,-0.022167481,0.030057792,-0.059580285,-0.043836106,-0.06638343,0.01589633,0.04714779,-0.012257822,-0.06794045,-0.05076098,0.017764857,0.028352704,0.047460865,0.051758125,0.06998447,-0.022275876,0.05062996,0.052217927,-0.0489461,0.0325537,-0.024725875,0.0783464,0.01914766,0.07449824,0.12573329,0.03319067,0.0058426526,0.020597925,-0.119822994,-0.0044008307,-0.076902054,0.02735412,0.027431773,0.037482783,0.012862896,-0.05999836,-0.050247673,0.039653417,-0.013179638,0.015067374,0.07041609,0.046866346,-0.010124896,-0.014258986,0.07681504,0.14540598,0.021546258,0.008814662,-0.022229247,0.030784566,0.034968626,-0.007889139,-0.047745757,0.056277238,0.06415543,0.021115454,-0.04937621,-0.072047606,0.029574817,0.0656615,0.007995157,0.041812543,0.04956528,0.0003796737,0.016340964,0.05811034,0.06376005,-3.4654683e-33,0.07773012,-0.02064656,0.009085826,-0.05084883,-0.07668691,-0.030513277,0.10455275,0.049894597,0.0461466,0.039492194,0.09955052,0.030742649,-0.04630542,-0.04621269,0.06014107,0.00092217,0.017164625,0.05233317,-0.0550145,0.020276254,-0.048048094,0.010729555,0.04231608,0.03645763,0.08128692,-0.004007878,0.0018015677,0.081531145,-0.0005771387,0.055894274,-0.020321956,0.046886235,-0.12156653,-0.01072295,-0.03816276,-0.007002985,-0.10079563,0.016835246,0.055002168,0.09735155,0.06613906,0.013038116,-0.024205877,0.04292272,0.07602772,0.018029686,-0.030268343,-0.02101438,0.013482613,-0.16141777,-0.030479088,0.06716345,0.094576284,-0.021492353,0.024464294,0.117818475,0.0139299035,0.05197264,-0.022583444,-0.05960822,-0.051370215,0.004755369,0.047951102,-0.080566354,-0.038194165,0.044952184,0.012548075,-0.025320647,0.022945555,-0.028564876,0.100179695,0.068133906,-0.026479306,0.039713807,-0.021067513,-0.031252164,-0.073805116,-0.028101834,-0.047320448,-0.03422258,-0.0015758373,-0.015321827,-0.06419636,0.0019633123,0.0044932636,-0.00665694,0.032119766,0.03454509,-0.0338022,-0.016077576,0.041797776,-0.053794548,-0.02672146,0.11498641,0.021987474,-3.7870123e-08,-0.0072879875,0.006530055,0.046179943,-0.011118259,-0.0457626,0.11200702,-0.013415382,-0.016615584,0.005362731,-0.041999876,-0.044222243,0.07622314,-0.025778912,0.072547525,-0.06375249,-0.016095942,-0.09808457,0.0031612567,-0.030893456,-0.017554615,-0.09722831,-0.020637106,-0.08382074,0.06703279,-0.019009558,-0.011955843,0.022000825,0.009319452,0.018215308,-0.049251433,0.041786797,-0.012430674,-0.04460876,0.0037579415,-0.018283686,0.016212825,-0.016767533,-0.03810033,-0.00087723444,0.03700253,0.007337464,-0.05715798,-0.034564503,0.028292436,0.071517624,-0.018752111,0.03971939,-0.04750193,-0.06113019,0.044246633,0.12540628,-0.053604722,-0.045658305,-0.022706965,0.059777364,-0.06707659,-0.077131316,-0.079521455,-0.04178956,0.072931185,-0.025482763,0.039674826,0.09705492,-0.020232815 +2.4.2.35,"Flavonol 3-O-glucoside, flavonol 3-O-galactoside and, more slowly, rutin, can act as acceptors.",384,1.0,-0.035925146,-0.16144766,-0.10617822,0.09857042,0.052247476,0.0006443923,0.030879134,-0.0037632466,0.08923685,-0.06809998,0.010347676,0.07819477,-0.079116456,0.013693819,-0.0119801,0.0060392055,0.033612497,0.110354885,-0.043710306,0.034428116,0.046432503,-0.06444096,0.07439793,0.023748545,0.016822292,-0.0007517014,0.024188697,-0.034673914,0.026691716,-0.13851428,0.030627232,-0.019147,0.0888584,-0.0107678315,-0.10624513,0.020870518,-0.059225634,-0.08517084,-0.017703148,0.03162251,0.020426724,-0.03809311,0.03731607,-0.020776432,0.044611383,-0.12370129,-0.09919431,0.010948584,0.06925743,-0.006026478,0.0032942041,-0.0522418,-0.0877698,0.0518909,0.01868757,0.024298325,-0.11501331,-0.048295192,0.032789093,0.035043783,0.092939235,-0.035070367,-0.0012536702,-0.034629673,-0.07352393,0.0004263951,0.005485812,-0.01791921,0.00919093,0.06568874,0.038383376,0.015193106,-0.06974866,0.013071405,0.042501397,0.045787036,-0.013869112,0.070214175,0.0059872316,-0.009872412,0.05577309,-0.0145025365,0.03899625,0.07770315,-0.0024499716,0.015469404,-0.044389933,0.054392938,-0.05700827,0.026227506,0.009913916,0.01077036,0.030185007,-0.022079244,0.020234542,-0.016210668,0.044250537,-0.07937884,-0.013109319,-0.0059298445,-0.03528908,-0.037732232,-0.0073981523,-0.02364216,-0.050678544,0.04420488,-0.0741539,-0.04763872,0.050676208,-0.033172764,-0.02811287,-0.09518209,0.0041232626,-0.03626511,-0.11463975,0.053576194,0.0073128147,-0.06984079,-0.029761529,0.0108654,-0.022241982,0.05898436,0.03332774,-0.0013624798,-0.01605993,-0.021449896,0.025573084,2.6279519e-33,0.0018934844,0.011901922,-0.046968102,0.027225953,-0.017844522,0.026228674,-0.033608768,-0.057794098,0.012498119,-0.058271796,-0.14871572,0.0082620885,0.017224602,0.056673694,0.050040416,0.055935428,0.029067604,-0.037524745,0.05843511,-0.045351434,0.04105164,0.0317433,-0.0946204,-0.008441844,-0.028366162,-0.03488859,-0.02629866,0.021122254,0.051108938,-0.022771863,0.0354796,-0.049262214,0.012990735,0.08568185,-0.040244885,0.065227725,-0.037874017,-0.10456244,-0.014892414,-0.018934412,-0.03093874,-0.01166623,-0.093561456,0.06912774,0.036868975,-0.010891537,-0.006510247,0.005335697,0.03285116,0.11575159,0.043098863,0.00029280758,-0.027675059,0.07978619,-0.040329844,0.024823688,-0.021438545,0.07609453,0.06752786,0.085977904,0.030450525,0.010180046,0.038174216,0.003014636,-0.042517632,0.08624165,-0.048745792,-0.012540215,-0.022884725,0.007915185,0.006885044,-0.036066618,0.054557744,0.052821968,0.028340898,-0.013779821,-0.015521723,-0.0060097473,0.013271818,0.019880584,-0.036973346,-0.035934377,0.011163536,0.15171596,-0.09982468,0.036087226,-0.009618457,-0.055480007,0.069942385,0.0221817,-0.003811321,-0.04677958,-0.032379787,0.05942121,0.0032650295,-1.9302896e-33,0.09789433,-0.07980092,0.068517156,0.06022523,0.03231468,0.06486669,0.010868686,-0.10400414,0.06621518,0.0017692773,0.10300586,-0.058792662,0.009506995,-0.015624681,0.009776008,0.0014056735,0.013159562,0.064590186,-0.056086153,0.0532965,-0.062733285,0.034727618,0.0045397715,0.061091695,-0.0029778958,0.0018553042,0.07882051,-0.0937542,-0.046964876,0.064537734,-0.014981717,-0.011802792,-0.08460397,-0.05935268,0.05178269,0.026264908,0.019652497,0.021325255,-0.082261704,-0.042887274,-0.002917482,0.029774498,0.013268476,0.078557685,0.086007155,0.020715311,-0.0048004915,0.033987995,-0.0064101857,-0.009892461,0.020685835,0.019528808,0.007709694,0.061685085,0.06418347,0.0016270853,0.06845702,-0.06170212,0.0370807,0.019159308,-0.057874613,-0.06452537,0.11543341,-0.031965747,0.08620709,0.017471856,-0.018166138,0.06346304,0.048533645,0.00034633602,0.06897695,-0.091353126,0.038701016,0.14406322,0.048979223,-0.02241329,-0.030124884,-0.042375296,-0.015317947,-0.024408497,0.009011363,-0.01007736,-0.0077386145,-0.04444066,-0.015804933,-0.026813878,-0.011797029,-0.0012217113,0.04481854,0.043405455,0.013347088,0.011333965,-0.014024582,-0.0022439733,0.06731024,-2.94191e-08,0.04410976,-0.0045688697,0.014746526,-0.004634909,0.04248699,-0.011897904,-0.012401351,-0.018529976,-0.10391966,0.015226624,-0.028873922,0.09937828,-0.016385958,-0.06414191,0.00489108,0.042887952,0.030234663,0.047235135,0.02333515,-0.017512023,-0.10826336,0.029025117,-0.005937692,-0.059064753,0.010580567,-0.06568205,0.026659317,0.06997326,0.104565725,-0.03882608,0.08906151,0.0019029054,0.019690298,-0.008162383,-0.06056136,0.005152195,0.02001949,0.06620308,-0.032392826,0.03117554,-0.061575767,-0.005258897,0.03418776,-0.02400524,-0.08060562,-0.013075904,-0.02302833,-0.021476688,-0.00605189,-0.01909086,0.004837955,-0.058976464,-0.027073761,-0.008675598,-0.09524715,-0.039005235,-0.0022129084,-0.05771924,0.015182365,-0.09053323,-0.08633135,-0.052894697,0.09216894,0.077220194 +2.4.2.36,"Diphtheria toxin and some other bacterial toxins catalyse this reaction, which inactivates translation elongation factor 2 (EF2). The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC 2.4.2.31 NAD(P)+---protein-arginine ADP-ribosyltransferase. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii.",384,1.0,-0.008088815,0.014043333,-0.08707751,-0.05340868,0.09806404,0.012906694,-0.03292895,0.08200475,-0.007865385,0.02549785,0.06918854,-0.061050426,-0.0722246,0.07433866,-0.05286559,0.008600027,-0.115955606,-0.0130905835,0.018898413,-0.04857648,-0.0114094475,0.0933168,0.0065131714,-0.053805027,-0.0013661354,-0.0021171956,-0.016268754,0.0339005,-0.0057132356,-0.101557225,0.0025212017,-0.015058999,-0.037908167,-0.10359147,0.10313739,0.03511175,-0.031961363,-0.0051528825,0.0408847,0.02321633,0.05320328,-0.011564603,-0.042989153,-0.05514512,0.01576915,0.053875826,0.036292788,0.04956362,0.09574685,0.017195206,-0.046403024,0.007373291,0.026379718,-0.036983017,0.068491936,-0.081991166,-0.017743368,-0.066036075,0.009912272,-0.034671493,0.02897739,-0.060473558,0.040447533,0.012339052,0.050643966,-0.05878532,0.08206293,-0.09832009,-0.016114015,0.017515825,-0.10276453,0.019321013,-0.0020586702,0.112062775,0.08228693,0.02719501,-0.07431205,0.013500445,0.04106417,0.0443374,-0.014803629,-0.04981109,0.024971187,-0.004701059,-0.013408424,-0.0030406513,0.01940774,-0.027130129,0.023275716,0.05150127,0.07216563,-0.054212105,0.0061670435,0.0033630414,-0.07095656,-0.0059566167,0.03188828,0.032015096,-0.050038055,-0.03473839,-0.028714288,0.033100817,-0.09864807,-0.018663285,0.008557522,-0.02160753,0.008779237,0.07345903,0.0040649134,-0.00036047696,0.00037619847,-0.018732565,0.005562271,-0.10934392,0.021212261,0.102008365,0.034416735,-0.08276653,-0.025267644,-0.06702971,0.009142845,0.043140754,0.027059887,0.11334424,-0.056152433,-0.036670003,-0.10977488,3.7846874e-33,0.051731963,0.08704011,0.049221966,0.060253244,-0.020845048,-0.02850638,-0.10972463,-0.0103409905,0.025893992,-0.12322948,-0.08124016,-0.085623674,0.13438602,0.007537255,-0.051320773,-0.050725225,0.04765516,-0.04166946,0.0560662,-0.03263183,0.03423106,0.036405016,0.05865738,-0.021607712,0.024077026,0.015085444,-0.028882448,-0.014445809,-0.0034972916,0.0027970152,-0.05397911,-0.099593475,-0.10014461,0.034109425,0.04582404,-0.09981839,0.04450113,-0.10932884,0.00453321,-0.024270022,0.032802418,0.038532846,0.0007437131,-0.05500998,0.036542464,-0.096059084,0.040745273,-0.0051589357,0.002605084,-0.016881479,0.046011314,-0.0023620452,0.108430654,-0.04380491,-0.044292253,-0.01093331,0.050813884,-0.03750773,0.06897588,0.0887029,-0.005483525,0.047015212,-0.03636076,0.06724103,-0.004776725,0.011341551,-0.019876564,-0.043786008,-0.012823744,0.06902404,-0.027086489,-0.041353945,0.067407094,0.022072379,0.008296678,-0.08312222,-0.07256693,0.031994563,0.0068523507,0.011159007,-0.00014356019,-0.03774404,-0.04813121,0.019269802,-0.03578283,-0.03088716,0.025306197,-0.050880488,0.067388766,0.09705724,0.0040540574,-0.01979827,0.016675772,-0.0030716818,0.09120502,-6.214906e-33,0.08455933,-0.0877805,-0.003424817,-0.046323087,-0.048349712,0.052452106,0.0667899,0.100100905,0.061248586,-0.085103005,0.09308704,-0.01628191,0.035426237,-0.06025226,-0.019397259,-0.024707606,0.01976635,0.101071574,0.05183755,-0.017033853,0.029226962,-0.022112615,-0.0071994397,-0.0023873546,0.013573336,0.025906365,-0.024768282,0.020056307,-0.034603465,0.010998174,-0.05945176,0.017520139,-0.043472182,0.021580534,0.021640036,-0.04198211,-0.05861594,-0.009068532,0.012865259,-0.0076422314,0.01737788,0.03934666,-0.014994192,0.0054940344,0.05896953,0.087339535,-0.028131472,0.079953216,-0.007034627,-0.074709386,0.014674885,0.075925335,-0.0074112024,0.033343624,0.023912191,-0.00713084,0.067103975,-0.033733007,0.064309664,0.053189702,0.023200413,-0.085983954,-0.0324953,-0.025087526,0.05456492,0.060487706,-0.050862804,0.02323835,0.022226257,-0.052396055,0.054880995,-0.026451297,0.044128004,0.0139464885,-0.027257442,-0.00045884622,0.0019315893,-0.0124501735,0.078456536,-0.01216409,-0.025596006,-0.044473886,0.018108899,-0.034362756,-0.0053551276,-0.07140316,0.016838208,0.009633473,-0.032358997,-0.067639224,0.00928711,-0.025171967,-0.043186698,0.07008849,0.097812645,-4.3525965e-08,5.612645e-05,-0.013984299,0.04597038,-0.046545345,-0.017616853,0.00836828,0.008230339,-0.0071791974,0.03680387,-0.040707108,0.047912013,0.09355713,0.058950495,-0.029573306,0.0023416348,0.006745781,-0.052189935,0.030041741,-0.0034182004,0.03675415,-0.03868309,-0.033094108,-0.021596128,-0.041693673,-0.018662548,-0.03815957,0.03259021,0.014340749,0.05599692,-0.18959779,0.00065960456,-0.040317565,0.024934812,-0.0055182367,-0.08747281,0.0461335,-0.05014883,-0.040261935,0.031013686,0.032437537,0.026633937,-0.02071272,-0.08303836,-0.038654447,-0.011621429,0.07705598,-0.0072091008,0.026363079,-0.08269143,-0.10698168,0.028310036,0.03707609,0.048326526,-0.032879606,-0.09706388,-0.0079952795,-0.075834505,-0.0529721,0.014638592,-0.06749054,0.098668955,0.011109461,0.08053531,0.031775083 +2.4.2.37,"The combined action of this enzyme and EC 3.2.2.24, ADP-ribosyl-[dinitrogen reductase] hydrolase, controls the activity level of nitrogenase (EC 1.18.6.1). In the presence of ammonium, the product of nitrogenase, this enzyme covalently links an ADP-ribose moiety to a specific arginine residue of the dinitrogenase reductase component of nitrogenase, blocking its activity. ",384,1.0,-0.019021548,-0.05922361,-0.059106532,-0.06632357,0.059023444,0.017302679,-0.007964957,-0.03632022,-0.017000731,-0.052917916,-0.050912037,0.020979617,-0.0605815,0.036920927,-0.11811851,0.016774544,-0.08598427,-0.047212783,0.027664628,-0.05679487,0.045535732,0.057463165,-0.029573841,-0.01817262,0.034626536,-0.061460044,0.026940068,-0.02500396,-0.06511087,-0.07377146,-0.0018186826,-0.038905688,0.092686065,-0.050580196,0.073564515,0.095594965,-0.041567385,-0.03947437,-0.04431505,0.08684371,0.038394455,-0.033768427,-0.014550657,-0.062488582,0.01596257,0.027417459,-0.02811409,0.07468124,0.03928652,0.010089868,-0.05182299,-0.03114504,0.025839549,-0.038319144,0.0024920448,0.027634243,-0.039983086,-0.028739482,-0.06655603,0.028564623,0.02892168,0.022747893,-0.016520033,-0.047600158,0.1281294,-0.029419472,0.057877347,-0.09006196,0.008023138,-0.002076606,-0.018464837,-0.052279577,-0.04088061,-0.035784546,-0.016089167,-0.073801786,-0.048330422,-0.009590919,0.10691357,-0.082001485,-0.0017372627,0.036183674,-0.0147292325,0.028769108,0.0030324918,-0.021498183,-0.06454978,-0.024468217,0.051165204,0.018024577,-0.03853255,-0.064181454,0.015763653,0.0485374,-0.0007322669,0.04118926,-0.04800656,0.068956226,-0.006496921,-0.04535437,-0.017227422,0.08447372,-0.109698586,-0.08157857,-0.06204451,0.07519705,0.03651935,0.08435958,0.0160559,0.07161611,-0.0021733989,0.01814992,0.028491603,0.00075101975,0.024758583,0.07690267,-0.006543321,-0.086650014,-0.061527863,-0.010627629,0.021907097,-0.025990644,0.04747372,0.10615044,0.025924021,0.069152355,-0.07899671,1.2550017e-33,0.059988365,-0.010308513,0.00524994,-0.0057460163,0.012221166,0.029419687,-0.0927813,0.0069500357,-0.01559305,-0.040750343,-0.032337073,-0.017810741,0.04415281,-0.051873352,-0.05411136,-0.040918738,0.055670816,0.044818986,0.023400985,0.044352245,0.046192624,0.027376136,-0.11253121,0.114325404,-0.008288685,0.012875306,-0.022922471,-0.0024389792,0.074445836,-0.025997186,0.0346481,-0.0965153,-0.07406906,0.027073748,0.010744209,-0.10095619,-0.039787505,0.024315955,0.003116214,0.075281195,-0.0047956314,0.06835666,0.04483427,-0.071900696,0.036469456,0.014312156,-0.033318903,0.10484206,0.028574828,0.066850625,0.051188312,-0.04053159,0.11175481,-0.0841302,0.024585247,0.03628653,-0.04328052,0.036030773,0.055331115,0.00048602087,-0.02485328,-0.0009574056,0.023247818,-0.0060537723,-0.10136979,0.06605877,-0.005094446,-0.079462506,0.08575407,0.05533801,-0.11397989,0.0700456,0.111788765,0.053580914,-0.0063193124,-0.07306905,-0.018303888,0.0061795907,-0.022198888,0.032865338,-0.02114671,-0.008271579,0.016446784,-0.005779641,-0.007008244,-0.022053055,0.008683263,-0.0135661205,0.027227381,0.043192916,0.0621081,-0.06068517,-0.10862378,0.005057609,0.09387694,-1.6490834e-33,0.121238,-0.114216916,-0.002942325,-0.07565828,-0.07767367,0.010546597,0.026507705,0.0051188837,0.06460519,-0.03012118,0.08298798,0.0052340315,0.037263088,-0.03564635,0.013942947,-0.025117472,0.0044852355,0.1141297,0.0059688017,0.00060878677,-0.027667785,0.061149247,-0.020513887,0.030810395,0.030967643,0.0053467266,-0.05638419,0.07721279,0.071907714,-0.0005444721,-0.025306495,0.023125868,-0.05266785,-0.022785675,0.031279325,0.028448772,-0.030687466,-0.0047137253,-0.043011837,-0.043342534,0.019158632,0.05929423,0.04048196,0.09256216,0.04180664,0.068614,-0.025954885,0.0046710437,-0.052714474,-0.067178205,0.063901976,-0.06740468,0.028602831,0.03924689,0.023690442,0.07402436,0.072295964,0.08010558,0.034624286,0.03963138,0.042410266,-0.05021249,-0.031862143,-0.021079492,-0.03827595,0.015061943,-0.037827272,0.06576236,0.05276067,0.047131654,0.013633177,-0.014929617,0.106501415,0.07321103,-0.03556155,-0.059128772,-0.051261123,-0.007900781,0.009804175,-0.06428152,-0.057201028,0.010069974,-0.068608604,-0.040780354,-0.016529134,0.009444918,0.046293594,0.10290104,-0.042795982,0.025032561,-0.037493452,-0.06462138,-0.09616185,-0.013806502,-0.00193664,-3.7944815e-08,0.08908083,-0.009879756,0.039433897,-0.08340614,0.04733965,0.030318297,0.029159643,0.031070469,0.05294078,-0.042863622,0.046000905,0.04365496,0.015637234,-0.062213607,0.04437062,-0.023997268,-0.0030627889,-0.035985824,-0.05047531,-0.0035413655,0.023273842,0.013849273,-0.14441912,0.039324436,-0.05922298,-0.015089336,0.057966635,0.036651216,0.02165929,-0.08989387,0.0059756883,0.037374906,0.09363142,-0.03035827,-0.068462536,0.045149602,0.013110355,0.033187132,-0.0022024224,0.007638646,-0.049263682,-0.097431764,-0.009733034,-0.027218921,-0.030895744,0.030575223,0.00015775269,-0.036135282,0.012345044,0.029378489,-0.022754218,-0.007012308,0.01733802,-0.022160165,-0.031489074,0.026522733,-0.0074167824,-0.10746233,0.033006065,0.022486698,-0.006024233,-0.023702456,0.084049635,-0.015635664 +2.4.2.38,Specific for N-linked oligosaccharides (N-glycans).,384,0.99999994,-0.024213044,-0.045214053,-0.07327304,0.03861771,-0.018284196,-0.036757927,-0.028320668,-0.0031122668,0.050610993,-0.022944726,0.060025193,0.07851023,-0.058299758,-0.020835357,-0.10544466,-0.03314288,0.05584706,-0.006649618,0.0013933416,-0.009902296,0.081904076,0.01641337,0.01853577,-0.025699023,0.001756087,-0.0718458,-0.020159464,-0.008017141,0.04408032,-0.100542225,-0.03704107,-0.050377082,-0.008489566,-0.011173209,0.012027199,0.027827952,-0.007392329,0.042080313,-0.006309198,-0.023840977,0.035364933,-0.019401094,0.06554005,0.018398605,-0.027413199,-0.0662449,-0.06691888,0.046015527,0.015271573,0.0390456,-0.011666266,-0.087142624,-0.063284464,0.050381176,0.12108303,0.02477315,-0.16194025,-0.059358787,0.07645494,0.0992751,0.077138595,0.03844345,0.0113666905,-0.032933954,-0.019282045,-0.008809439,0.066258185,-0.006201924,-0.07808682,0.08592083,0.005805541,0.02803198,-0.0106439935,-0.00011235154,0.039213948,0.083629526,-0.050106324,-0.021645816,0.008853793,0.005793238,-0.015385009,0.11324377,0.061296303,0.0695316,-0.027416471,-0.016509421,-0.024405112,0.06844846,-0.0087480005,-0.00024231676,-0.03670011,-0.003803119,0.07145315,-0.021021489,-0.0840985,-0.04226397,0.04491735,0.02707035,0.03239566,-0.033952035,-0.022896368,-0.037086073,0.07443069,-0.058129437,-0.10778847,0.07863439,-0.021892358,0.039418705,0.08372756,0.034370366,-0.038034175,0.016557304,0.0016290994,-0.060430564,-0.12481527,-0.009562951,-0.018881414,-0.051707204,0.05246083,-0.009804612,0.0004804212,0.018122837,0.029781947,0.008364394,-0.043151118,0.09337374,0.004457605,-1.2353338e-33,0.08712575,-0.0005495327,0.06368605,0.014568511,0.06985663,-0.03679678,-0.013605429,-0.0586344,-0.023799088,-0.0127940485,-0.06791513,0.0018277471,-0.013168478,0.1369867,0.011467777,0.09307411,-0.018686917,-0.057285875,-0.0010586538,0.009745543,0.007810096,0.07781437,-0.010423327,-0.021243712,0.05776102,-0.027910339,-0.045975395,-9.822541e-05,0.083718486,-0.011042393,0.11362199,-0.047327083,-0.06664894,-0.007145525,0.060603872,0.03738187,-0.015467537,-0.024979932,0.02644882,-0.0097534545,-0.003600327,0.062208407,0.024132706,0.0064133652,0.02207718,0.0011508908,-0.03110201,-0.010625764,-0.057412222,0.06676156,0.057813983,-0.024324704,-0.031450823,0.053708542,-0.046607323,0.05667809,-0.016667694,0.004603311,-0.04558853,0.07672836,0.010854037,-0.010949137,0.017263314,-0.097694896,5.570974e-05,0.051383972,-0.05676304,0.013624064,-0.026517188,-0.04059488,-0.042921588,-0.039509114,0.061036322,0.03881566,-0.026097875,-0.0494523,-0.025962519,0.010583993,0.017197564,0.016511304,0.019733202,0.010139259,-0.009909528,-0.02011077,-0.0954273,0.049315464,-0.03691337,-0.059080638,-0.010829644,0.048925374,0.004192741,-0.017325327,-0.07514485,0.00425633,-0.10509235,-1.1735726e-33,0.10079604,-0.09199211,0.0999853,0.042585827,-0.052533288,0.0057632304,0.0055170897,-0.023674613,0.042163756,-0.06263508,0.066012755,0.034021813,0.048163243,0.0062844744,0.03384011,0.008824787,-0.0778205,0.12644376,-0.024825217,-0.020161254,-0.092178896,0.026388783,0.0039578523,-0.022063969,0.09913538,-0.005875919,0.02678156,0.03433849,-0.02318905,0.039621927,0.018529007,-0.0036384556,-0.103142336,-0.07040067,-0.020043746,0.038364343,-0.012888845,-0.07705308,0.004055605,-0.07353947,0.053114273,0.0346693,0.06271505,0.034360554,0.02291652,0.072075486,-0.09162638,0.032741144,-0.039220482,0.025970656,-0.0039024225,0.0057391203,-0.023570813,0.045322493,0.055395383,0.07040556,0.06539388,0.033121362,0.020854743,-0.03841598,-0.040431403,-0.028091509,0.013835784,-0.03770398,0.05270521,0.035978433,-0.039033182,-0.03127564,0.038097095,0.007333967,-0.0056272876,-0.012133514,-0.0069812937,-0.032008834,-0.032528915,0.007870919,-0.09663414,-0.037117414,-0.059600674,0.00856045,0.00016121153,0.0028358647,0.0368456,-0.022282245,0.07217663,-0.005296887,0.10245065,0.10737618,0.03417401,0.073728755,-0.01917382,-0.08030904,-0.03781182,0.032997526,0.000999555,-2.1876412e-08,0.071408585,-0.032995,-0.06113074,-0.10366013,-0.08627085,0.023216419,-0.031082708,0.015092486,-0.04492759,0.044604883,0.040360417,0.09575406,-0.03296047,-0.00049248827,-0.05017825,0.024093438,0.04926036,-0.008522508,-0.024971243,-0.016635396,-0.17497998,0.03377809,-0.06995541,0.09371199,-0.029971972,-0.061871823,0.091938354,0.02043725,0.0046916045,-0.062083498,-0.011797726,0.032474726,-0.007951982,-0.105772056,-0.0010528098,0.047215957,-0.045088705,0.003148052,0.01824081,-0.034357894,0.022945266,-0.018000519,-0.023212584,-0.03631734,-0.006610068,-0.00506889,-0.00838971,0.088502936,-0.10681167,0.062789105,-0.035670705,-0.041089837,-0.050351784,-0.06843437,-0.10584731,-0.045647196,-0.00022190518,0.010959178,0.014859774,-0.04455403,-0.055282302,-0.01310815,0.14528106,0.027063357 +2.4.2.39,"In association with EC 2.4.1.168 (xyloglucan 4-glucosyltransferase), this enzyme brings about the synthesis of xyloglucan; concurrent transfers of glucose and xylose are necessary for this synthesis.",384,1.0,0.0044377083,0.0067208037,-0.09633496,-0.03946866,-0.0045078862,-0.028745783,-0.022305738,0.02299035,0.039676543,-0.042106174,0.04414453,-0.016007366,0.0030271907,-0.00127619,-0.06296865,-0.0112907,-0.06434075,-0.047475245,-0.022064205,-0.022700936,0.09861474,0.007906689,0.032419764,7.866843e-05,0.049186893,-0.0746279,-0.0066853254,-0.122827046,-0.03429413,-0.08703513,-0.008458403,-0.061550893,0.016840957,-0.032439534,0.030617224,0.04058134,-0.010740214,-0.070873804,0.020587571,0.01498795,-0.001141499,-0.062204506,-0.009931994,0.013866004,-0.052463766,-0.05773435,-0.0041383575,0.003997191,0.0064875763,0.0513381,0.027265487,-0.050180066,-0.06903369,-0.0053838505,0.082429565,-0.010103018,-0.099281676,-0.020908397,-0.0029017099,0.047280345,0.06968977,0.09185819,-0.039082896,-0.0106826695,-0.020748528,-0.10351938,0.08996706,-0.04854754,0.02363602,0.014351589,-0.075149395,-0.03693734,0.0043750005,-0.00039492422,0.05833537,-0.009868418,0.02133179,-0.013174088,0.0499997,-0.022208748,0.08794913,-0.0014421339,0.036605567,0.02994406,-0.017485226,-0.06578797,0.034829304,0.016786058,-0.0079014115,0.007928777,0.052999407,-0.05877007,-0.010226245,0.023398617,0.04686276,0.032043222,0.054616384,0.02469287,0.11576187,-0.050329227,0.022133436,0.023800282,0.0554486,-0.041416798,-0.058174487,-0.012143697,-0.0031481131,0.11995278,0.0056205443,-0.07014218,0.0017798985,-0.054860946,0.011210707,0.03710209,-0.036368072,0.13013858,0.0142066255,-0.0981385,-0.0618982,0.018091768,0.033877626,0.0012482275,0.06415819,0.05381321,-0.009879045,0.03899099,-0.0595887,1.2809782e-33,0.024347115,0.07870155,-0.0068178857,-0.027799152,-0.033870105,0.0013344774,-0.082816534,0.046528995,-0.10466771,0.031295024,-0.083629206,-0.082324214,0.014876626,0.079436794,-0.06045898,-0.01948661,0.0497044,-0.038903583,0.05089139,0.045555864,0.020827657,0.062071994,-0.028666578,0.010779887,0.04292775,0.100155644,-0.02173364,-0.016452972,0.038203,-0.007084289,-0.03373691,-0.05619708,-0.03485673,0.07845194,0.02391867,0.034597054,0.007979384,-0.03569461,0.052174773,0.024127582,0.023660975,0.015330326,0.017459925,-0.12628636,0.08923102,0.008565572,-0.121136345,0.025079925,0.031618938,0.101311944,0.02178469,-0.010507005,0.053447537,0.06688178,0.00930102,0.0019233224,-0.048840318,-0.0052358597,-0.008794051,0.009052576,0.03945015,0.05344124,-0.05260197,-0.0191905,0.004366621,-0.008110405,-0.02719165,-0.06624315,-0.106838375,0.038324855,-0.09840714,-0.077069536,0.0824555,-0.031927776,0.08671122,-0.047786154,-0.10061759,0.094399355,0.021520281,0.035546977,-0.010280056,0.03940911,-0.015595019,-0.02819071,-0.07976843,-0.012255072,-0.020182868,0.036891825,0.03376658,0.16542763,-0.09201774,-0.025641797,-0.068027735,0.035840925,0.018162241,-3.3504065e-33,0.10134409,-0.05242975,0.015646106,-0.021778189,-0.012309886,0.043317094,0.032659624,-0.10227564,0.05706026,0.042275257,0.12700732,0.030213306,0.016742324,-0.046606634,0.06767968,-0.014598082,-0.075875446,0.034566063,-0.054345645,0.01674097,-0.0011036365,0.08282935,-0.021132458,-0.00687821,0.074374594,-0.05631333,0.033145204,0.06397437,0.023558814,-0.00093398563,-0.0756586,-0.06908003,0.0019763391,-0.01026873,-0.0510651,-0.0050552157,0.012476697,0.049818777,-0.032950874,0.03033034,0.033422615,0.09322641,0.0486943,0.05471962,0.09023232,0.0874928,-0.01816923,-0.0016695916,0.007501445,-0.008761366,0.05396664,0.007724072,-0.020824501,-0.0017737573,-0.0050198017,0.088845864,0.004204604,0.016640788,0.010651548,-0.0039888695,-0.08258688,-0.08859129,0.048599415,-0.068436846,0.09422373,-0.03832793,-0.06210564,0.019761516,0.029904038,0.04522144,0.06057872,-0.06916546,-0.058839347,0.045243014,0.010626367,-0.022596207,-0.10748416,-0.08253783,-0.0121042365,-0.10995499,0.008803059,0.0008176143,0.08370317,-0.080824144,0.0371849,-0.036145054,0.033522062,0.094240375,0.012938084,-0.008837874,-0.03565268,-0.018223967,-0.017047722,-0.03456517,0.025167756,-3.218331e-08,-0.01367994,0.011581197,-0.035646576,0.0075341747,0.02543415,0.026676629,-0.0024226622,0.050668027,0.008392497,0.012736927,-0.005273255,0.08351617,9.1993286e-05,-0.015120645,-0.029559182,-0.04505493,-0.030976905,0.019703887,-0.0044331597,-0.029322915,-0.052515797,-0.015325843,-0.10154515,0.048727427,-0.0043738675,-0.10338051,0.089798085,0.04061143,0.025683977,-0.084170826,-0.034789905,0.070106976,-0.023260476,-0.024362141,-0.09410519,-0.028004775,-0.045866165,-0.009088955,0.055353522,0.030053027,0.018231299,-0.017713826,-0.05864102,0.0024934448,-0.01346815,0.00086402247,0.0067036054,-0.07071712,0.010018291,0.050558843,-0.0022077519,-0.00061028433,-0.004608603,-0.07191323,0.0032217281,0.01337638,-0.03786192,-0.0010008619,0.0785698,-0.06138202,0.018984254,-0.024505852,0.13246578,-0.060842577 +2.4.2.40,Does not act on UDP-glucose (cf. EC 2.4.1.103 alizarin 2-beta-glucosyltransferase).,384,1.0,-0.06708145,-0.062320754,-0.09107144,-0.0060722064,0.020652179,-0.029892338,-0.030533671,0.047445096,0.025267323,-0.05536391,0.03002846,0.037731715,-0.11617721,0.07054123,-0.06341343,-0.024041295,0.0007135786,-0.016821336,0.031279147,-0.041536592,0.045318402,0.027645066,0.06245492,-0.00919741,0.05325698,-0.040951256,0.05235182,0.020761922,-0.0096296435,-0.083422996,-0.050310936,-0.03590744,-0.025374103,-0.023178402,0.07607042,0.10843595,-0.021960942,-0.061389655,0.0011459514,-0.042148504,0.12898204,-0.06506737,-0.046536088,0.037479784,0.032574553,-0.06372613,-0.06997901,0.05350421,-0.0021199156,0.055303752,-0.03984782,0.008420411,-0.042149633,0.063639924,0.044720486,-0.015457111,-0.10494393,0.01539072,-0.017682543,0.0017405673,-0.052165415,0.017403955,-0.0071661295,0.00578651,-0.00818899,-0.012689791,0.07447133,-0.10135396,-0.056995362,0.03241086,-0.057488654,-0.04083566,-0.05977365,0.07232053,0.0049002925,0.015283139,-0.061640307,-0.019085554,0.03853234,0.0012923137,0.03121656,-0.050325405,0.113417186,0.04652265,-0.053608865,-0.05964418,0.011075029,0.037890766,-0.08255076,0.012053587,-0.014829001,0.029182823,-0.0043169386,0.05002738,-0.056356277,-0.01952789,0.023879442,0.015338374,0.01471895,-0.009492618,-0.041292705,0.06353844,-0.042361163,-0.038285963,-0.037251983,0.0201557,-0.03689655,0.010378352,-0.010449079,-0.002932734,0.006009163,0.028000267,0.09450524,0.025558732,-0.04029168,0.048994653,-0.019381313,-0.05591616,-0.05831402,0.051922124,-0.00537858,-0.05707659,0.040155064,0.037789416,-0.04477711,0.058830976,0.018959653,-1.1294927e-33,0.061715454,-0.11438614,0.02987854,-0.033306535,-0.008017556,0.039796606,-0.094141535,0.00047012072,-0.040346656,0.043867104,-0.058802836,-0.06281861,0.026850065,0.10853462,0.0044235806,0.07538309,0.06635786,-0.051780615,0.04869758,0.0090494305,0.027211476,0.079450585,-0.04470623,-0.044383395,0.030192818,0.121426314,-0.09997108,0.08285859,0.068137646,-0.0025354116,-0.004577788,-0.080527715,-0.051299725,0.021978421,0.007344524,0.032909017,-0.028364943,-0.037644427,-0.0007100469,0.034492847,0.05120524,0.013229234,0.019060168,-0.08479613,0.04304825,0.02000149,0.02033467,-0.04401417,0.016812367,0.07100188,0.03917518,-0.022952266,0.032157622,0.0036261012,0.038529955,0.020017102,-0.0337048,0.026007803,-0.048861638,0.02627244,0.036709476,0.032801945,-0.0009898684,-0.06640742,-0.040825512,0.025407532,-0.08622622,-0.043847863,-0.0821525,-0.0046944576,0.008084717,0.026478633,0.09695303,0.02192412,0.066503525,-0.069592156,-0.007333399,0.05881515,0.04204263,0.0009435547,-0.034262404,-0.027527975,0.030534917,-0.029685557,-0.071692124,0.021989327,-0.024434753,-0.015983194,-0.010761374,0.018112054,-0.064580046,0.03765127,-0.10346292,0.0012037688,0.041796193,-3.255141e-33,0.06546833,-0.040131465,-0.00068399945,-0.02218832,-0.03797315,0.056159057,0.05488843,-0.06934511,0.09186531,-0.0005053337,0.124880016,0.00807568,-0.026002046,-0.05288319,0.07627123,-0.00015874638,-0.11092839,0.051479228,-0.083665825,-0.0062954705,-0.058056485,0.13358821,0.011736719,0.11519117,0.0655362,-0.02855148,0.00515167,0.017354654,0.047033343,-0.004252055,-0.018637301,0.027915455,-0.09397964,-0.04862018,-0.012191324,-0.025933499,0.0064663365,0.008784872,-0.12370436,-0.012835702,0.05975962,0.09577529,-0.0508561,0.02896574,0.1114671,0.07340514,0.03686952,-0.025979787,-0.028550336,-0.050080057,0.008713469,0.012543118,0.00978413,0.05252762,0.05228522,0.11537153,0.07484806,-0.0328777,0.010000599,-0.01634934,-0.031327736,-0.09098641,-0.017223893,-0.082128674,0.07594122,0.05496468,0.019574972,0.0221375,0.110104196,0.04132531,0.040917885,-0.06365447,-0.0010369227,0.0194199,-0.025730941,0.05101846,-0.119148016,-0.034397576,-0.0140579175,-0.08654197,0.038758636,0.018272744,-0.029054567,-0.023853958,0.036030956,-0.042168453,0.011965565,0.0035473192,-0.041798633,0.0686111,-0.010040901,0.0004756191,-0.009799173,0.005248843,-0.018236162,-3.356883e-08,0.05817479,0.048914876,0.011137959,-0.029086042,-0.036475156,-0.0131838145,0.024669606,-0.035284426,0.033748914,0.019155184,-0.08278062,0.09831554,-0.016268114,0.010669968,0.0071974876,-0.025891833,-0.011835515,0.033919152,-0.0007099751,0.0013046823,-0.12876439,-0.027036965,-0.13551515,0.041416172,-0.049467113,-0.10220161,0.075433254,0.024264593,0.054672983,-0.060652055,0.021141786,0.07916635,0.029173018,-0.013554701,-0.06798312,-0.043437205,0.024117708,-0.007369411,0.015812924,0.086963154,-0.0121050915,-0.05359812,-0.008948884,-0.018707884,-0.03572688,0.029085448,0.053472992,-0.04867866,-0.026599964,0.00661445,0.043522358,-0.0056101396,-0.09379464,-0.0702239,0.0217693,-0.021168793,-0.056223914,-0.005706099,0.022544004,-0.07211467,0.0043808585,-0.058306616,0.0710551,-0.056923382 +2.4.99.1,The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.,384,1.0,-0.010004428,-0.06310756,-0.070787385,0.035052888,0.027333735,-0.0080871815,-0.017007725,0.011427267,0.062494148,0.022465998,0.015580096,0.1076609,-0.05159991,0.0219088,-0.06996625,-0.03535726,0.04227208,0.040626936,-0.03610191,0.030923296,0.09958505,-0.044489115,-0.016151235,0.025810272,0.098154604,-0.022885092,0.013943645,-0.06008862,-0.025608646,-0.052683253,-0.014968637,-0.05382268,0.064302444,-0.011269931,-0.007029565,0.022961747,0.034606826,-0.0140373185,0.009235503,-0.03045123,0.034334105,-0.008378162,-0.00073463825,-0.03027091,-0.067606196,-0.0032770035,-0.0075315526,0.052980106,0.07246311,0.05141669,-0.00046766983,-0.092084095,-0.05789487,-0.033733264,0.0572207,0.08048353,-0.0362212,-0.0637247,0.048301846,0.081356965,0.030957267,0.028891558,0.035343613,0.06780656,-0.03708045,-0.11162831,0.050824217,-0.033498224,-0.039602432,0.026713906,-0.030051526,-0.017625283,-0.03569146,-0.04354325,0.07598296,0.017434772,-0.03575814,-0.009221539,0.08392843,-0.024543257,0.06055593,-0.015414483,0.08724898,0.026268722,-0.056811184,-0.028058393,0.06332186,0.015092511,0.030997913,-0.020954786,0.017125795,-0.048862007,-0.02497578,-0.023343695,-0.045448016,-0.06735572,0.09103441,-0.036683444,-0.013312435,-0.031844083,-0.013967267,0.00065769005,0.069900945,-0.027256062,-0.06291111,0.0836222,-0.020209718,0.025434256,0.052610256,0.032084394,-0.0041785613,0.021599868,0.05048237,0.0066058813,-0.08194938,0.05066179,-0.005252522,-0.06750135,-0.051723424,-0.020208318,0.036370285,-0.017790388,0.051345512,0.039160207,-0.043802787,0.12563711,0.022857808,-5.2189506e-34,0.096832395,0.074228205,0.048968993,-0.03419941,0.0126355635,-0.041280717,-0.04460938,-0.019189304,-0.017849164,0.038982954,-0.016740814,-0.047949612,0.030917794,0.11180968,0.013468323,0.0936084,0.046534624,-0.044956166,0.05202131,-0.010376417,-0.016567342,0.020848803,-0.021290088,-0.03038688,0.098663576,0.051612455,-0.074039266,0.09380999,0.115719035,0.032849114,0.049902845,-0.06897709,-0.089629486,0.026349679,0.055988718,0.049816057,-0.031350724,-0.072436705,0.05181853,-0.014886537,0.013952781,-0.03340949,-0.04191835,-0.020634511,-0.024600172,-0.0033822092,0.021521427,0.008424934,-0.015293498,0.08267069,0.022248736,-0.039634608,-0.004707549,0.010111864,-0.038507693,0.077865966,-0.046427965,-0.04498251,0.0015528257,0.07182992,-0.048881497,0.025536273,-0.0022272717,0.006382926,0.048957873,0.028776519,-0.06036454,-0.016244106,-0.059209943,-0.01856103,-0.028218111,-0.06525407,0.070331134,0.027338952,-0.042247787,-0.051257588,0.041017603,-0.036751326,0.023561774,-0.015769096,-0.026474513,0.07242348,-0.022474138,-0.061266005,-0.016968625,0.013666456,-0.013091192,-0.06542118,-0.052730754,0.0019665195,-0.04715908,-0.015667096,-0.04215952,0.05572634,-0.04643323,-2.9835121e-33,0.118188664,-0.1436242,0.099006206,-0.03426304,-0.056074753,0.021674896,0.031515576,-0.06766418,0.05889534,-0.04524626,-0.0062529068,-0.030740332,-0.03787263,-0.06202128,0.009331139,-0.022093939,-0.06340719,0.08367412,-0.067810185,0.011264581,0.007570717,0.010881515,0.047808792,-0.037056644,0.019391699,-0.07048956,-0.003757246,-0.0038406735,0.0041095344,0.04920937,0.020357583,0.0012318784,-0.06138078,-0.088310346,-0.02295204,0.054756768,-0.10961734,-0.030676795,0.028711233,-0.039481103,-0.014749946,0.059232734,0.005930432,-0.006417358,0.10279551,0.053519957,-0.07151783,0.041355345,0.02622443,-0.08023589,-0.021214377,-0.025969569,-0.00234508,0.12711258,0.03141247,0.07668723,0.063725404,0.053413,0.0039319703,-0.049900968,-0.04501911,-0.017283525,0.022128744,-0.045800768,0.06773978,0.020801201,0.0072725588,0.014372464,0.06616467,-0.038365714,-0.0066670305,-0.052331284,-0.044544715,0.06647932,0.012238333,-0.011895704,-0.14557444,-0.046467222,-0.036926348,0.0057881773,0.040811826,0.05561964,-0.0070021925,-0.048580408,0.016313575,-0.047131043,0.053123612,0.16914225,0.0070774425,0.05386029,-0.038473137,-0.013740629,0.010827092,0.043406043,0.08016329,-2.7891149e-08,0.06851584,-0.013390259,0.024374235,-0.14937665,-0.05326848,0.0026622335,-0.023829564,-0.023765221,-0.044533785,-0.017255453,-0.02326164,0.08649717,-0.024769671,-0.024525555,-0.051783707,0.09495329,-0.04938959,-0.014462591,-0.0144350305,0.048159957,-0.08678875,0.0070711365,-0.071540944,0.04553242,-0.032112967,-0.06595894,0.0680663,0.049181677,-0.12314606,0.014667437,0.030288193,0.0587161,-0.06935379,-0.045347374,-0.03191909,-0.015037059,0.0007806827,0.008511105,0.0559469,0.012963916,0.007109643,-0.05494106,0.004865516,-0.031615097,-0.058342673,0.04033148,-0.009446612,0.016835488,-0.066194,0.09348078,-0.04753305,-0.026763588,-0.12080944,-0.06628475,-0.085690945,-0.03757057,-0.023310643,-0.02986393,-0.015820453,-0.0619574,0.02098936,-0.025325283,0.10144171,-0.035281718 +2.4.99.2,"The enzyme recognizes the sequence beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl (known as type 1 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids [1]. When acting on gangloside GM1a, it forms gangloside GD1a [2].",384,1.0,-0.041725524,-0.08093386,-0.0827309,-0.0034360518,-0.05025575,-0.052577913,0.0031429084,0.03811924,-0.037036806,0.045254648,-0.012085933,0.09878074,-0.02913751,-0.002658267,-0.0914926,-0.049185243,0.060465697,0.006121432,0.014514617,-0.018900521,0.07841764,-0.051526867,-0.016562909,0.0053500477,0.0696515,-0.024272513,0.020582566,-0.04127054,0.00078480993,-0.06366888,0.009671895,-0.07043966,0.09191052,0.03775413,0.012714257,0.026251404,0.032476906,0.025415685,-0.042354703,-0.01482477,0.033994082,-0.017446958,0.035026636,-0.034520376,0.0019011041,-0.080778964,-0.08124842,0.063629635,0.09398943,0.0297885,0.009507223,-0.06648344,-0.04929423,0.009207672,0.04120914,0.005950027,-0.053091727,-0.036848083,0.06013967,0.03557589,0.016799176,0.011660146,0.019657928,0.0026193073,-0.015633535,-0.07608343,0.0680137,-0.05470201,-0.03332049,0.056809116,-0.00228227,-0.02461969,-0.035133664,0.005878862,0.0109541705,0.043961905,-0.05321361,0.021466818,0.065602526,-0.032763097,0.059413165,0.037276965,0.105173595,0.07175446,-0.09152721,0.055804253,0.03734559,0.02596548,0.030567465,-0.02897214,0.004331918,-0.037150364,-0.0020259826,-0.021536067,-0.07432162,-0.02915563,0.09631487,-0.036896173,0.03426083,-0.045928802,-0.0032128291,-0.02731712,0.031256065,-0.017559335,-0.09845913,0.062249858,-0.050373774,0.052552905,0.07798605,0.0070230137,-0.043041036,0.06402572,-0.0015906916,0.008706,-0.094926864,0.024201749,0.022049835,-0.0451472,-0.021461826,-0.012218682,0.04723317,0.009357632,0.052915953,0.015156211,0.004864908,0.06241236,0.032365337,1.0350686e-33,0.077459425,0.014247375,0.039750762,-0.03472155,0.0054292562,-0.007088137,-0.058690276,-0.015470204,-0.005035899,0.027282646,-0.039008126,-0.050369844,0.015593234,0.10275751,-0.05796067,0.13310699,0.03576707,-0.09614384,0.049269173,-0.060165375,-0.05431029,0.035134178,0.012263596,-0.033857465,0.08794716,0.04228349,-0.047569886,0.056606527,0.10810753,0.022319663,-0.017800732,-0.03780951,-0.08423231,-0.000109601904,0.019786766,0.061367456,-0.007851988,-0.051947657,0.059535112,0.012175102,0.032022383,0.0038066737,-0.025828889,-0.062106654,-0.01986348,-0.0002988922,0.015911188,-0.0055342056,-0.02772592,0.066808805,0.02117686,-0.01671377,0.0019571774,0.037787203,-0.039568257,0.08072269,-0.019827018,-0.025762856,0.012161492,0.08467697,0.047223713,0.04408309,0.015769083,0.012178805,-0.014897506,-0.019351859,-0.04531789,-0.012151896,-0.051800933,-0.021607004,-0.047850896,-0.06707159,0.04249596,0.053044092,0.024205659,-0.07094561,0.08231257,0.012340708,-0.019922499,-0.012858167,-0.065004215,0.044050094,-0.029993756,-0.03210354,-0.057882793,0.0622863,0.0036260886,-0.13219227,-0.06139811,0.0067216894,-0.08462821,-0.016118601,-0.035397265,0.07454869,-0.024577823,-4.300549e-33,0.05936962,-0.098203845,0.10073824,-0.029110407,-0.028192515,0.02662621,0.014873939,-0.028210685,0.0847981,0.021876061,0.02921218,0.024455557,-0.048037905,-0.057827577,0.032267403,-0.018913908,-0.054867167,0.0670463,-0.071113795,0.052537877,-0.039230842,0.043221556,-0.0005536305,-0.022877432,0.025972674,-0.04017885,-0.015265628,0.047438126,0.03053015,0.019322272,0.005904337,0.044380378,-0.054698326,-0.10257161,-0.052446045,-6.1398634e-05,-0.07119174,-0.041019633,0.03958918,0.0011094386,-0.025736652,0.08072041,0.021687813,0.0074958852,0.1042382,0.08611859,-0.03099466,0.062275466,0.031220205,-0.056961883,-0.030868335,0.0045681703,-0.0064023174,0.13185635,0.08531344,0.04629456,0.07554746,0.07191457,-0.053606115,-0.01703092,-0.022291288,-0.014500197,0.003144036,-0.040118765,0.09761252,0.0248233,-0.0034420881,-0.0069951457,0.08877976,0.0070372177,0.031676006,-0.054802403,-0.035029195,0.05883316,0.022033583,-0.012633353,-0.15731455,-0.03918046,-0.02810842,-0.042094883,0.060708128,0.09116107,-0.02553886,-0.0077885087,0.038396183,-0.020576281,0.03855652,0.14962327,0.0159932,0.05229822,-0.028918786,-0.03214266,-0.031202395,0.038079,0.0005850112,-3.8166483e-08,0.072406925,-0.05205617,-0.025416605,-0.1481103,-0.060333285,0.013042852,-0.05731613,-0.0038827893,0.022017168,-0.04187861,-0.03490803,0.07394926,0.004438928,-0.016574549,-0.080909,0.10158113,-0.027634269,-0.028295618,-0.03615308,0.050196838,-0.10288149,-0.027831662,-0.07213722,0.040654194,-0.028817398,-0.1005071,0.04257157,0.033369463,-0.07360562,0.012562877,0.008922708,0.07442636,-0.024614912,-0.06661081,-0.015378564,-0.0006723715,0.004526843,0.026519964,0.12666918,-0.02501617,0.037132896,-0.01729535,-0.01192145,-0.028412117,-0.081152774,0.008405819,-0.0043165707,-0.0006807379,-0.063047245,0.04329164,-0.069055915,-0.006163026,-0.09451118,-0.104953125,-0.053546526,-0.046980094,-0.048954196,-0.032221753,0.041080493,-0.08899929,-0.018474812,-0.07141049,0.06736002,-0.0030058685 +2.4.99.3,"alpha-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.",384,1.0,-0.03613069,-0.062031113,-0.132734,-0.021143787,-0.009133029,0.028662806,0.06244845,0.029646222,0.031274494,0.020917004,0.0067385924,0.018771539,-0.066757575,0.048574388,-0.027789092,0.015501656,-0.024784725,-0.002546327,0.09334603,0.040462106,0.0055245026,-0.021056497,0.017962858,-0.008191039,0.0065440275,0.07326683,-0.028043423,-0.053579934,0.028673925,-0.07707434,-0.06209088,-0.017147345,0.04645003,0.020514539,0.014414056,-0.013103976,-0.089101814,0.011066563,-0.0030795098,0.017604096,0.025499284,-0.021814559,-0.0045281085,-0.03472151,-0.04678778,-0.03600977,-0.04066931,0.014009152,0.061098155,0.035129648,0.03240894,-0.008580301,-0.04256458,0.13240215,-0.04459951,0.057929367,-0.057095475,-0.005719222,0.028307438,0.033367712,0.04633882,0.025674809,-0.04842574,-0.048522174,0.0944346,-0.077806525,0.039504144,-0.111368574,-0.032859,0.054865282,0.0028666798,-0.0047772815,-0.017490614,-0.00011331213,0.061342444,0.0033689896,0.009529145,0.004458469,0.066257805,0.029961282,-7.791676e-06,0.04091091,-0.0022899404,0.12914132,0.034065522,0.03317207,-0.06937037,0.0065666623,0.090937294,0.06300455,-0.010651696,-0.05114162,0.03074519,-0.0766603,0.025763266,-0.023438375,0.021250676,0.055992648,0.03284139,0.07219684,0.05713498,0.0445661,-0.08282545,-0.06930374,-0.08956405,0.03945155,0.0038026527,-0.025032297,0.013526053,0.013767986,-0.097712174,-0.090202115,0.047039006,0.03466644,-0.10153886,0.06437416,-0.0074260915,-0.08210285,0.069426775,-0.086686745,0.0050648022,0.04243877,0.042519826,0.060555227,0.0056970553,0.03712315,-0.04203903,1.6505835e-34,0.03674224,0.07330823,0.0505168,-0.067555964,-0.018865684,0.01949371,-0.049696017,-0.023481572,0.019012723,-0.10070325,-0.0899853,-0.030974464,0.0743533,0.01706823,-0.03160107,-0.09468134,-0.023498613,0.073456824,0.022770023,-0.06397149,0.006406674,0.048789687,-0.048270352,0.06097694,-0.06748238,-0.022313591,-0.06297838,0.095115066,0.06924811,-0.0067334794,0.06971967,0.036692765,-0.022052726,0.041599195,-0.01374575,0.0072122184,-0.011896887,-0.038144745,0.015124328,0.022031695,0.015507609,0.08558961,-0.017478038,0.028883263,0.008385069,-0.1063983,-0.050667666,0.01936987,-0.041966073,0.039449055,-0.01834323,-0.05792177,-0.0048258365,-0.06324915,-0.03325563,0.037463866,-0.024111113,0.03497555,-0.004380666,0.026262831,0.016879024,0.007952444,0.037444975,-0.023372376,-0.081237204,0.04153281,-0.06546863,-0.011597401,0.042447876,0.02780086,-0.039284494,-0.009676126,0.050081976,0.08690727,0.04047733,-0.062722385,-0.064215414,0.05969221,0.0016536366,-0.05277754,-0.03726598,-0.012566993,-0.012169361,0.09130696,-0.09358421,-0.043022808,0.07194229,-0.10507859,-0.0063314037,0.015396412,0.022492385,-0.085318424,-0.072059795,0.049249902,0.051593907,-1.8823523e-33,0.05969516,-0.0904451,0.06765764,-0.0021159858,-0.071439266,0.07102896,0.0342963,-0.09678203,0.015743488,0.008345246,0.090869434,-0.016516082,0.020971667,-0.043988105,0.03944887,-0.0670012,0.00290323,-0.002866717,0.0018329005,-0.0009814481,0.008450108,0.032386348,-0.056534335,0.010200798,0.013159799,-0.022714809,0.013694246,0.006151989,0.036460247,0.07850669,-0.07780339,0.011944145,-0.021665432,-0.043363187,0.015013305,0.056071028,0.07969437,-0.0035068074,-0.05956978,0.0024959808,0.011364671,0.020910392,0.05789332,0.14908196,0.053730708,0.06777731,-0.0035953461,0.034676187,-0.043743182,-0.020437622,0.0063975416,-0.043421794,-0.0061896946,-0.004858548,0.027992578,0.10861853,-0.015674379,-0.03844525,-0.010548092,-0.042968422,-0.0024750754,-0.0033678554,-0.009063133,-0.05069623,0.027525473,-0.033408992,-0.08141989,0.08452469,0.081036076,-0.09677886,0.026848638,-0.005722125,0.11956298,0.041312758,0.041027408,-0.13463031,-0.032449845,-0.07735979,-0.0027319682,-0.11520208,-0.09495242,0.035677,-0.01631803,-0.058476694,-0.02620189,-0.007113109,0.078054644,0.08664327,-0.07103301,0.044038724,-0.029413693,0.020376166,-0.037383117,0.057219237,0.030954568,-3.178034e-08,0.044689953,-0.027614744,0.0029891836,-0.009572973,-0.026706824,0.011892865,0.023677647,0.009248258,-0.016565664,-0.058147326,0.0013664688,0.11294835,0.058494713,-0.043872524,0.040088035,0.015037898,-0.012032362,-0.023468822,-0.07427639,-0.014111114,-0.11610723,0.012215965,-0.0070630764,-0.06695348,0.014688102,0.021967284,-0.0121575,0.06939496,-0.090672985,-0.02101921,0.011448404,0.033979014,0.012213499,-0.12868011,0.037697643,0.072714984,0.044712648,-0.07818672,0.023862535,-0.0076986095,0.03107803,-0.009389365,-0.09583317,0.047706366,0.025327682,0.007094001,-0.005903962,-0.008317468,-0.09099604,-0.06976899,-0.008257443,-0.014017417,0.013642283,-0.03169243,-0.001791963,-0.017749727,-0.027102381,-0.054296546,0.019925822,0.011202625,0.032786287,0.014371291,0.12670457,0.016222475 +2.4.99.4,"The acceptor is Galbeta1,3GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid. Lactose can also act as acceptor. May be identical with EC 2.4.99.2 monosialoganglioside sialyltransferase.",384,1.0,-0.026620205,-0.06078323,-0.09826305,-0.03471896,0.04536878,-0.025303476,0.045471102,0.038864467,0.051661123,-0.05463034,0.075333565,-0.035617776,-0.089201175,-0.0062150834,-0.055075478,-0.014708166,-0.057516407,-0.006492757,-0.021152237,-0.0069327364,0.024885537,0.043793462,-0.0141955465,0.039871518,0.03719383,-0.0042574834,0.007058777,-0.03593653,-0.008183762,-0.1009391,-0.037843242,-0.068391636,0.071392626,0.016085627,-0.020589268,0.037096366,-0.012179275,-0.067342654,0.06273179,-0.026537219,-0.014380414,-0.07851207,0.06687981,-0.014971384,-0.04887965,0.0033292072,-0.029830657,0.07572984,0.02278649,-0.006828432,0.018171495,-0.050976213,-0.014354018,0.07913751,0.0138301095,0.055659276,-0.07026156,-0.036972433,0.014774853,0.02825539,-0.010334565,0.011710352,0.005703063,-0.0049069514,0.015905961,-0.034833394,0.03864494,-0.12412015,-0.03655843,-0.008837683,-0.023390872,-0.047715697,-0.048302196,-0.0492952,0.044280086,0.043927327,-0.008232385,0.02171429,0.08248169,0.05995199,-0.0041071484,-0.03089629,-0.0066853957,0.05478987,-0.0146531565,-0.05322733,-0.027639199,0.02842034,0.025713181,0.016177455,-0.04457569,-0.06138976,0.029099585,-0.04120275,-0.014947505,-0.011848773,0.03437805,-0.002637041,0.05970332,0.0025745735,-0.032037612,0.021927806,-0.037562143,-0.040383644,-0.11154935,0.073244065,0.032318383,0.04054784,0.04412318,-0.058739934,-0.058628276,-0.08967214,0.06642754,0.04967044,-0.08687491,0.06417956,0.019212896,-0.13191456,0.07104079,-0.05107271,-0.008023917,0.04607351,0.08289461,-0.0076446473,-0.01808192,0.06274779,-0.073777474,2.9231202e-33,0.00025242387,0.075892605,0.06988066,-0.072909616,-0.004756268,0.019070854,-0.07800681,0.013233421,-0.029498642,-0.07168154,-0.09540727,-0.05711695,0.013367425,0.054611363,-0.0073646735,-0.026083678,0.029097768,0.0686469,0.017137762,-0.018187508,-0.017944433,0.07819681,-0.065443516,0.012012439,0.01589827,0.05686024,-0.03525208,0.03248002,0.101300895,0.015075953,0.10366657,-0.03650224,-0.0051847105,0.044915102,-0.018374236,-0.014101643,0.04314008,0.023869952,-0.00080264144,-0.04053665,-0.0027462458,0.012873649,-0.061020754,0.03629451,0.027335787,-0.01697763,-0.014176928,-0.025630567,0.06353984,0.040436253,-0.04128699,-0.015516358,-0.04121977,-0.052537497,0.0024257186,-0.014155412,-0.03298359,0.14404929,0.008955406,0.04120734,0.009677903,0.116621636,-0.017924411,-0.01932345,0.01253668,0.030406484,-0.038013257,-0.081931114,-0.03680507,0.069635354,-0.059933152,-0.045987103,0.038233895,0.10472787,0.056527637,-0.0518905,-0.036967557,-0.014851888,-0.017815603,0.013595033,-0.12678331,-0.008092811,-0.0019167002,0.03311194,-0.12239229,-0.011050657,-0.04346306,-0.099537954,0.019285172,0.041359764,0.015037887,0.017055176,-0.047497492,0.057217825,0.011260238,-5.2641142e-33,0.09353959,-0.09723169,0.063233815,-0.00045793687,0.020011678,0.03925297,0.018719403,-0.024893234,0.11894875,-0.039564334,0.099831864,-0.0011911758,0.010828286,-0.026959864,0.05147114,-0.0394425,0.0014054462,0.08092729,-0.05214974,0.06218402,0.030887257,0.070917875,-0.008888354,0.0072953813,0.019853862,0.02924629,0.0010397279,0.02909484,-0.017494965,0.03205717,-0.046977185,0.021484783,-0.0414836,-0.07774514,-0.055069268,-0.026982244,-0.07603172,-0.026429355,-0.02638397,0.042481504,-0.0074227247,0.031171747,0.019157063,0.09918014,0.044434234,0.014457895,0.012388962,0.016603954,0.015834628,-0.046714526,-0.06304129,0.03831536,0.039066523,0.054967504,0.11895211,0.09913166,0.053122606,-0.05196147,0.027790446,1.8317904e-05,-0.010450806,-0.027186297,0.041891273,-0.040064864,0.049493562,-0.022197662,-0.07343627,-0.011853148,0.082994066,-0.0014214485,0.09588563,-0.067136325,0.008785587,0.09745556,0.07004287,-0.033668898,-0.10131162,-0.074327365,-0.028137917,-0.08066168,-0.05009099,0.044263944,0.03783107,-0.0070660277,0.054339934,-0.10260588,-0.00064725394,0.029925251,-0.014168272,0.042412046,-0.042727463,-0.0017545252,-0.055829413,0.0536551,0.0505378,-4.305152e-08,0.027318593,-0.0523377,-0.011066405,-0.091797605,-0.018495055,0.056081682,-0.03615917,-0.010908683,-0.035249736,-0.011236789,-0.03131349,0.14111379,0.023248626,-0.12608594,0.030863108,-0.03314483,0.010915532,0.027456548,-0.029121863,0.038974572,-0.08175254,-0.011936636,-0.022939697,-0.11742983,-0.040785324,-0.029353438,0.017478824,0.08864384,-0.07132034,-0.07058216,0.05213519,0.07716524,0.034413647,-0.029618526,-0.0009051689,0.06095294,-0.033605363,-0.012591348,-0.013263687,0.018602151,0.07172726,-0.037537873,-0.07874899,-0.019189399,-0.03160417,0.05735268,0.0041413736,-0.029189143,-0.064911954,-0.03448617,-0.027597966,-0.03204397,-0.01370755,0.05800119,-0.016598027,-0.04061774,-0.04492942,-0.027019145,0.004256481,-0.04672324,0.09509472,0.03073158,0.14650539,-0.04843186 +2.4.99.5,The beta-D-galactosyl residue of the oligosaccharide of glycoproteins may also act as acceptor.,384,1.0,-0.019815966,-0.09098379,-0.045219254,0.04098612,0.04197687,-0.013410515,0.03645345,0.018128488,0.051639266,0.020380342,0.05159823,0.12136152,-0.053133126,0.053227104,-0.06642593,-0.039771277,0.04616356,0.034529917,-0.024829688,0.05015605,0.057876352,-0.011931793,-0.01847595,0.008043011,0.086776264,-0.03995961,-0.018338831,-0.045049217,-0.0026794893,-0.06010373,-0.042037014,-0.06925654,0.06730044,0.0033642761,-0.012791512,-0.004204668,0.016921816,-0.024695374,0.003391038,-0.03566882,0.012001289,0.008607314,0.02012346,-0.019424424,-0.08251737,0.007775958,-0.0069775255,0.045579784,0.07190963,0.043614984,-9.375277e-05,-0.09100386,-0.069716066,0.0011204368,0.04873436,0.08727675,-0.052628506,-0.0673746,0.05474003,0.03965201,0.00628146,0.01619739,0.027927577,0.056183763,-0.04497173,-0.11561201,0.06657003,-0.02037536,-0.055401284,0.06008834,-0.0007082012,0.005730519,-0.04233413,-0.026954556,0.08071332,0.040086117,-0.05376135,-0.030462103,0.092798986,0.0029236854,0.03725165,0.016492082,0.08567152,0.00039406845,-0.055958144,-0.035952453,0.03485498,0.019920973,0.0083083445,-0.025909709,0.012916486,-0.056787327,-0.0070830984,-0.055294283,-0.022177044,-0.101212755,0.118646994,-0.026860267,0.02924394,-0.035463795,-0.045538735,-0.016219506,0.059175905,-0.021286784,-0.058058586,0.05823451,-0.029934255,0.0025821691,0.064761035,0.04072726,-0.022653485,-0.015431219,0.06464571,0.0073811086,-0.08580659,0.016008414,-0.009909078,-0.074191295,-0.03692476,-0.05499239,0.020661332,-0.0030976594,0.0480206,0.02171864,-0.038992044,0.091176815,0.019760212,-1.6227918e-33,0.068737306,0.040351517,0.062420532,0.0043286704,-0.002445858,-0.027372058,-0.03003355,-0.03272613,0.0065911394,0.0041366243,-0.0475683,-0.050609052,0.022479892,0.13410509,0.009570845,0.11520053,0.022552794,-0.03190287,0.04436368,-0.025827624,-0.01107378,0.009170845,0.0011618015,-0.039708078,0.073558986,0.023168145,-0.07471315,0.09217074,0.10425022,0.033217046,0.09232826,-0.060449593,-0.06367923,0.031460803,0.05470393,0.054857403,-0.0082715945,-0.062498897,0.058875546,-0.032326795,0.029080411,-0.031229049,-0.07632659,-0.018133368,-0.003655633,0.031683244,0.014087229,-0.020488843,-0.041419767,0.06917333,0.022014499,-0.04051228,-0.06523704,-0.010816333,-0.031193938,0.0820809,-0.03863851,-0.028697902,-0.03893192,0.08438849,-0.02975317,0.040461637,0.00011055175,-0.009939154,0.026369484,0.027804345,-0.062258482,0.0029191794,-0.0543016,-0.030186448,-0.010046078,-0.06841567,0.03975695,0.046673752,-0.057199005,-0.070134915,0.029222982,-0.015342395,0.039175704,-0.023633188,-0.022643885,0.06081292,-0.04225378,-0.022276593,-0.043316957,0.011438473,0.001574469,-0.08632677,-0.026245555,0.035793945,-0.04256093,0.002903524,-0.04595954,0.053155452,-0.04263178,-2.5239261e-33,0.13182922,-0.13585716,0.10365005,0.004334643,-0.024607744,0.031849965,0.04098678,-0.04203948,0.08797164,-0.04032105,0.026701862,0.0019588673,-0.044119228,-0.039638035,0.024280367,-0.061830003,-0.082284346,0.09724922,-0.078115985,0.030168168,-0.019662363,-0.03125901,0.044776622,-0.04585138,0.041733775,-0.035933614,-0.034359425,-0.0051474096,0.0029970647,0.062944174,0.016253283,0.026833339,-0.077520184,-0.103581406,-0.02119865,0.0009229805,-0.10672488,-0.03029612,0.013988238,-0.03888625,-0.0044133845,0.06571081,0.02510715,0.0026864568,0.10322507,0.02613159,0.0062203715,0.022038173,0.035420015,-0.068083175,-0.014034565,-0.04595129,0.007379395,0.10481607,0.03358478,0.09892514,0.07807798,0.039222814,0.021622997,-0.043913398,-0.050936434,-0.006924758,0.021117285,-0.04685399,0.032893557,-0.009645241,0.010522606,0.003644708,0.09201728,-0.044093903,0.0043839817,-0.06276345,-0.026640002,0.048481464,0.020670837,-0.016088445,-0.16683541,-0.023373326,-0.03929616,0.012233638,0.00062428263,0.077281214,-0.020091692,-0.0075237183,0.06425551,-0.045303978,0.033905134,0.12040759,0.0039868653,0.024524022,-0.053032853,-0.008637648,0.023145104,0.065115236,0.07776468,-2.6032893e-08,0.046084285,0.000914261,0.016366504,-0.13805129,-0.05917056,0.015021253,-0.014645346,-0.031967785,-0.05550688,-0.0036042563,0.007637711,0.10124544,-0.038594484,-0.045692965,-0.063901015,0.07983476,-0.08601351,-0.02889204,-0.008584585,0.053900376,-0.10514687,0.014564871,-0.03561476,0.0370732,-0.06812604,-0.039128274,0.047361016,0.06909704,-0.11813114,-0.0014832161,0.04854326,0.0528174,-0.073428586,-0.056348104,-0.0017015387,-0.030185422,0.011917235,0.00235068,0.06603155,0.012843038,0.020043189,-0.024891611,-0.0040687923,-0.03938419,-0.04651896,0.040066604,-0.015400454,0.034226064,-0.09219402,0.07268452,-0.05137606,-0.03263228,-0.12881723,-0.030216318,-0.06584641,-0.03241081,-0.035631105,-0.014102118,-0.027016493,-0.044870026,-0.0033127393,-0.043173835,0.09416206,-0.015357999 +2.4.99.6,"The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1 [2].",384,1.0,0.0028386435,-0.085849755,-0.09033111,-0.0015034165,-0.07248411,-0.03758976,0.013921597,0.019253025,-0.011826403,0.035370834,-0.019356335,0.07677281,-0.034271866,-0.006830843,-0.09295626,-0.013617176,0.049842954,-0.047272447,0.026954288,-0.00050489104,0.044285618,-0.05676534,-0.013240867,-0.012867486,0.06439121,0.0030146441,0.018989574,-0.04636642,-0.0265806,-0.033365794,0.051085535,-0.07083565,-0.010252033,0.025617722,0.031674813,-0.018871482,-0.030550214,0.036970474,0.018721381,0.017022442,0.034187067,-0.06706899,0.016331557,-0.0102363955,-0.013350119,-0.03945276,-0.06863834,0.014820321,0.09516551,-0.0028976162,-0.02565939,-0.06934412,-0.038630012,0.030203445,0.012762448,0.023577584,-0.07569145,0.017463688,0.022953821,0.060547743,-0.022201063,0.022040328,0.015097183,0.02094653,-0.010873904,-0.06356148,0.03068137,-0.10754745,-0.056246307,0.05735432,0.023352252,-0.053329114,-0.010143942,-0.016012298,-0.0014168449,0.023638723,-0.027037736,0.041165285,0.064648174,-0.054909196,0.06371266,0.042223882,0.07433882,0.087354004,-0.038276,0.06569864,0.045621168,0.052160814,0.0017753121,-0.026702758,0.016228411,-0.071478225,-0.022691913,-0.0106835095,-0.054228667,-0.054993186,0.09388174,-0.060173437,0.052790027,-0.047805417,-0.030771606,-0.010346245,0.029540062,-0.042036876,-0.05684945,0.08946266,-0.005337008,0.019624293,0.08225804,-0.014166012,-0.04895496,0.09074662,-0.016401652,0.027553065,-0.039257057,0.0092244735,0.03839513,-0.016314542,-0.011980183,-0.029328357,0.07163187,-0.0032471174,0.063982785,0.00514765,0.0046753786,0.09384646,-0.008604865,2.2415482e-33,0.062616065,0.021975132,0.01760465,-0.041343935,0.03151961,-0.020272378,-0.05738979,-0.008942594,0.0012824411,0.035209034,-0.0067797913,-0.09468356,0.0020841523,0.13304952,-0.021025509,0.11940816,0.04645817,-0.095445305,0.08743321,-0.08777994,-0.06985767,0.057843987,0.007526388,-0.015091295,0.041385517,0.08141812,-0.07154549,0.057202246,0.10250985,0.024266055,-0.02892304,-0.06209405,-0.054523047,0.009986662,0.01069257,0.07225123,-0.033227555,-0.06022515,0.07406994,0.054185126,0.070036516,-0.011365883,-0.016590627,-0.042700615,-0.0250197,-0.014483722,-0.028058035,-0.0026596517,-0.0005599134,0.0169936,0.013040905,-0.024898399,0.04925208,0.023968222,-0.021241736,0.083771266,-0.030761033,-0.016379302,0.04597687,0.08590165,0.04064851,0.039981414,0.018691419,0.009172931,0.021126179,-0.05919226,-0.060607124,-0.04678988,-0.10040864,-0.030326556,0.0028461996,-0.09413272,0.09266888,0.008642376,0.049047355,-0.04819953,0.060915504,0.015786754,-0.035931658,-0.03557753,-0.039851848,0.031737603,-0.0010318953,-0.029665068,-0.029670574,0.06621293,0.009074248,-0.11493671,-0.022014046,0.014077577,-0.09428656,-0.030391205,-0.032999262,0.026159463,-0.040363204,-4.7222584e-33,0.020200847,-0.068403386,0.08963564,-0.02471489,-0.029923676,0.041806314,-0.006292992,-0.037230723,0.04928635,0.07429318,0.00858208,0.04375004,-0.042143032,-0.079881005,0.025079168,-0.023534777,-0.07242927,0.059265967,-0.03275982,0.023206014,-0.019949134,0.092583515,-0.013247888,-0.0037427742,0.06364317,-0.03252814,-0.007684811,0.05493886,0.02348134,0.0026646953,-0.013566592,0.045039587,-0.061389253,-0.13705292,-0.008678605,0.018722123,-0.062636726,-0.04875199,-0.008742107,0.016005553,-0.029865133,0.06473544,0.04660522,0.00817418,0.13156316,0.03385595,-0.02456277,0.011847647,0.0019389883,-0.020178048,-0.05115689,0.005657526,-0.023876768,0.091394536,0.073731594,0.05265472,0.04263146,0.05601906,-0.0069940994,-0.046205617,-0.029442344,-0.032693118,0.0037809904,-0.02842071,0.13728642,0.03574334,-0.0036955646,0.029931167,0.07733259,0.019880125,0.018047493,-0.02921049,-0.036317907,0.078902744,-0.00461824,0.023274584,-0.15981442,-0.04834389,0.020462215,-0.029388431,0.05619989,0.01804387,-0.012382611,-0.03203319,0.020246424,-0.057603214,0.0094303405,0.15227206,-0.030584088,-0.0036267398,0.012635206,-0.07495554,-0.044784054,0.05275463,0.0083297165,-4.164129e-08,0.07896719,-0.09524376,-0.01676452,-0.09370443,-0.005818326,-0.05568701,-0.05963655,0.005724082,0.045801207,-0.02158095,-0.08379153,0.04360929,0.028784627,-0.033437032,-0.101108044,0.13426521,-0.003134088,-0.009551647,-0.023385597,0.04556922,-0.07309179,-0.00418647,-0.034139328,0.019190785,0.002246005,-0.12227607,0.05331401,0.076543175,-0.09749279,-0.008738798,-0.021234853,0.065361716,-0.01039403,-0.07212962,-0.020850714,-0.035957687,0.005888175,0.0024297098,0.1461118,-0.009209852,0.014185974,0.0012386536,-0.0075492123,0.005763084,-0.06260761,0.015604782,-0.008880954,-0.030041935,-0.031007104,-0.032906022,-0.057070814,0.010901606,-0.0516255,-0.09779473,-0.064653546,-0.013758056,-0.049306285,0.027981192,0.065553464,-0.09543921,-0.003019308,0.025407443,0.10595777,-0.028336203 +2.4.99.7,"Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure of alpha-N-acetyl-neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.",384,1.0,-0.027162258,-0.15445417,-0.10043186,-0.0035661908,0.07215477,0.06690476,-0.014033421,-0.014059832,0.02882058,-0.024534754,0.023092601,0.03487801,-0.045215286,0.034121573,-0.07977026,0.05554231,-0.059238795,-0.008592229,0.026885714,0.03082491,0.031769156,-0.04894357,0.0019004857,-0.044588484,0.049001135,0.0311695,0.029837623,-0.08974797,-0.020222101,-0.12356951,0.021402681,-0.07663774,-0.004484978,-0.0117285615,0.07032134,0.015631696,-0.014558672,-0.01955815,0.026874019,0.026616115,0.032979976,-0.024599923,-0.0050969664,-0.03196758,0.020595511,-0.013686428,-0.0626683,0.041202396,0.08539276,-0.015381965,-0.020836156,-0.05338848,-0.010676849,0.06373966,0.02012849,0.121978395,-0.051416513,-0.04846871,0.047701206,0.12522484,0.11158401,0.035641186,0.018319706,-0.024176365,-0.015264903,-0.038177498,0.096045226,-0.033165198,-0.01608246,0.03025716,-0.095741056,-0.029932411,-0.006157645,-0.012748767,0.016828218,0.011000479,-0.034838624,0.030439463,0.0679722,-0.03486532,-0.01496826,0.022844778,-0.052148573,0.057461955,0.027216628,0.011182725,0.008672199,0.006734764,0.044195924,0.057145253,-0.04429463,-0.07628776,0.09337265,-0.07609495,-0.048639253,-0.0087744305,0.033536255,0.0001520955,0.027527845,0.017368559,0.010781817,0.05589132,0.012198284,-0.0634245,-0.049733408,0.07423667,-0.05143089,0.07413137,0.05627509,0.029413037,-0.020212105,-0.017832909,0.006512298,-0.010249283,-0.081899896,0.0698257,-0.053999692,-0.04987731,-0.03358616,-0.03143942,0.047293615,-0.036984462,0.052092314,0.034272965,-0.024685726,0.0940743,-0.015398459,3.2224095e-33,0.062521875,0.0783631,0.050893486,0.01338873,0.014368268,0.04463507,-0.111213855,-0.021081213,0.02484503,-0.07839809,-0.06392904,-0.04300584,0.011986805,0.0074102296,0.044220127,0.12840676,-0.015273031,0.027194919,0.04160556,-0.009064738,-0.0017101794,0.053643454,-0.09197222,-0.019931346,0.0026423198,0.022662591,-0.040258627,0.018966088,0.05381643,0.0014672079,-0.059826966,0.0024919843,-0.030131882,0.05378361,0.035567388,-0.031595092,0.037320495,-0.117821,0.06145398,-0.022141593,0.069802485,0.075318485,0.03231409,0.021075966,-0.007996287,-0.042342104,0.030269915,0.03287957,-0.016974732,0.01609977,-0.047041968,-0.04962005,0.062174156,0.015963975,0.00094090117,-0.008022238,-0.10206158,-0.024097746,0.060893293,0.030105203,0.018200554,-0.0001829007,0.036606077,-0.058544952,0.0046514035,0.021653127,-0.022434743,0.0046001747,0.0024964386,-0.024791202,-0.058766294,-0.026365623,0.0163236,0.06615288,0.0056205275,-0.084537275,-0.031487927,0.021223055,0.06807916,-0.013754759,-0.021629231,0.03355818,0.03883231,-0.04849216,-0.019785255,0.021367062,0.022159636,-0.0714805,-0.045029603,0.020887293,0.040258374,-0.07698643,-0.05799467,0.10173297,0.026772613,-3.9067334e-33,0.115848914,-0.106730126,0.05925514,-0.036452234,-0.03986611,0.05214992,0.011946357,-0.04627336,-0.018786363,-0.0056310254,0.059585538,-0.0127276415,0.032332856,-0.07620992,0.09554745,-0.07874138,0.099376194,0.059042033,-0.010397399,-0.036500726,0.041609522,0.022869008,-0.027261663,0.045363676,-0.004570408,0.0021607815,0.012184158,-0.004186071,0.017899701,0.10867227,-0.02082586,0.0330379,-0.09827098,-0.05510337,0.0032562139,0.025297914,0.023930434,0.025010878,-0.038056668,0.008684016,0.051585354,0.07991593,-0.017406393,0.047990948,0.03557136,0.04404177,-0.020105131,0.010305211,-0.019191613,-0.04208585,0.06613127,-0.052818425,-0.047408327,0.02988132,-0.038670633,0.05143248,0.01891007,0.053076167,-0.0037854547,-0.06033986,-0.06651987,0.002427813,-0.035208464,-0.09737761,0.017422808,0.016580394,-5.000276e-05,0.11284498,0.061695855,-0.0726514,-0.023547782,-0.026073636,0.09633883,0.07056333,-0.002823622,-0.086465135,-0.07198973,-0.10026803,0.027043974,-0.09576291,0.0052603954,0.020039093,-0.0071510673,-0.07857738,-0.011982247,0.018495794,0.10200129,0.10113662,-0.031362887,0.023823602,-0.03456288,0.034064874,-0.085114054,0.060907714,0.017181806,-4.618215e-08,0.12658358,0.011238902,0.025896993,-0.081132464,-0.024210073,-1.1862931e-05,-0.06841285,0.0729345,0.057875738,-0.043741934,-0.02800741,0.106808096,0.029876115,0.048678756,-0.06205759,0.034837656,-0.003302762,-7.664073e-05,-0.025075307,0.006759146,-0.07449565,-0.0043007606,-0.033407416,-0.008381341,-0.03431008,-0.115288325,0.061852686,0.066998444,-0.008980704,-0.057419494,-0.038626596,-0.019438857,-0.060059812,-0.03904755,0.012054439,0.041407563,0.06102494,-0.07790734,0.0481585,-0.022091825,0.0036424224,-0.021411128,-0.04143026,0.040115036,-0.022672819,0.0035916958,-0.011594054,-0.021266282,-0.061084304,0.031918813,0.0145032415,-0.053919658,-0.0631836,-0.119914934,-0.101980604,-0.08396183,-0.017664555,-0.024602156,0.040562965,-0.016225817,-0.0030761592,-0.03132491,0.109721065,0.016376244 +2.4.99.8,Gangliosides act as acceptors. ,384,0.99999994,-0.03402235,-0.03686014,-0.031843852,0.006949272,-0.05255484,-0.082503766,0.04199679,-0.024242079,-0.005125874,0.020541063,0.03041063,-0.027730528,-0.03791626,-0.043294404,0.008860507,0.023261743,0.030067908,-0.025976002,0.023208506,0.04010323,-0.09288495,-0.08476399,0.019903528,0.022412052,-0.051930636,0.061428126,-0.08670755,0.029653182,-0.006550085,-0.06814746,-0.00027649285,0.0065535516,-0.040907215,0.07667554,-0.05979197,-0.009986074,0.022749962,0.07588123,0.06357702,-0.0051598996,0.036841422,-0.050467804,0.039495748,0.0030172674,-0.05262202,-0.020156989,-0.05992573,0.02239791,0.041228686,-0.09719284,0.025315775,-0.018076494,-0.02145058,0.055819716,-0.0774565,0.011107422,-0.045003638,-0.033140805,0.065711394,0.0064289044,0.012776875,0.036527008,-0.051633283,0.03627553,-0.021442581,-0.00018757333,-0.074138716,-0.039442647,0.01860619,0.09130356,0.06359081,-0.017033065,-0.0544829,-0.024164988,-0.03775224,0.033882566,0.01751287,0.033664655,0.06786049,-0.07285518,-0.046470355,0.017249752,0.028921166,0.055433538,0.0350009,0.029869597,-0.015274826,0.051579345,-0.014299707,0.03310503,0.044700988,-0.05450948,0.016251467,-0.052811284,-0.08997844,-0.062268384,0.019550718,-0.026807688,-0.003013394,0.04616921,-0.044041645,-0.04471218,-0.042649895,-0.007087801,-0.05681578,0.014219937,-0.034758635,-0.058611717,0.0058521,-0.025759423,-0.091823354,-0.0348531,0.011505402,0.05925038,-0.029120421,0.01964241,-0.045247547,-0.0024561216,-0.011557733,-0.09399559,-0.029277934,0.053586435,-0.03441236,-0.014046142,0.021583248,0.024601463,-0.05456878,-2.3570104e-33,-0.013069234,-0.009823761,0.010956791,-0.10172115,0.008287187,-0.02482227,-0.08131428,-0.031331025,0.0455348,0.048824962,-0.038381014,-0.051813792,-0.012332931,0.044256512,-0.01150743,0.041185733,-0.022264116,0.014866253,0.013751515,-0.08620884,-0.051704623,0.11650678,-0.040204406,0.0043180315,-0.036004044,0.016376512,-0.036236078,0.049219884,0.06786978,0.0563553,0.08753546,0.007949313,0.028945541,0.032578666,-0.023429302,0.111275956,0.005114628,-0.032680534,-0.049322452,-0.093372546,-0.004086162,0.0425481,-0.119925655,0.030549817,0.008317594,-0.005652357,0.014706293,-0.056454025,0.049243443,-0.00714949,-0.023034275,0.030462893,0.04717327,0.02574274,0.03120279,0.044956174,0.015266941,0.038225777,-0.010736451,-0.002517329,0.08364135,0.033655133,-0.017854948,-0.037745386,-0.0183498,0.059145678,0.028948868,-0.053496327,-0.034509182,-0.03748856,-0.019507218,-0.007107477,-0.022773094,0.07820448,0.01797655,-0.056018993,0.02071682,0.0023523844,-0.03426265,-0.04704745,-0.13249655,-0.03064118,-0.014045605,0.039272774,0.02754858,0.038630582,0.055647522,-0.101010635,0.033006288,-0.024416119,-0.06851296,-0.015671387,-0.018647334,0.10455448,-0.073504545,2.8902272e-35,-0.036330935,-0.0040628063,0.0087338,0.050027676,-0.00447991,0.110454895,-0.05648264,-0.00015802121,0.09900764,0.092108235,-0.058776498,0.0912126,0.02446398,-0.06363539,0.090621985,-0.09506134,0.010181586,0.081448495,-0.053245742,-0.012296753,-0.026036587,0.13539933,-8.224899e-06,0.07227394,0.030392893,0.042812046,0.0028859193,-0.037094507,0.005547436,-0.028085275,-0.0031143308,0.02606901,-0.05387251,-0.11119311,0.020850483,0.020492373,-0.036070284,-0.006748746,-0.031753782,0.021074038,0.008434133,0.042017076,0.010107567,0.10881014,0.0310631,0.008901541,0.036156707,0.09843737,-0.09736827,-0.018198403,-0.06714924,0.046467233,0.033465225,0.043033767,0.06810795,0.056675527,0.026859198,-0.044606153,0.014599988,-0.09075107,-0.01842348,-0.01791752,-0.065032005,0.020665675,0.064808875,0.025518442,-0.024988983,0.025581539,0.09494755,0.015595312,0.087789096,-0.1017281,-0.07779427,0.104690045,0.07465752,-0.0011261102,-0.10617023,-0.10463183,-0.007837842,-0.03082371,-0.07315648,0.03971526,0.07887969,0.0018681012,0.044183742,-0.019331107,-0.017085668,0.003799574,0.022954749,0.10180602,0.06384854,-0.053535987,0.040083535,0.06936948,0.020894246,-1.6641968e-08,0.105183095,-0.0059896503,0.00465006,0.016888916,-0.088540465,-0.039892107,0.0073616444,0.03193882,0.0023386967,0.058085546,0.015907815,0.058035653,0.064031065,-0.0008414427,-0.04155186,0.09345748,0.067164056,-0.05929629,-0.0984744,0.0059695877,-0.07675136,-0.0011340869,0.08234434,-0.040725406,-0.005388743,-0.020346193,-0.04480815,0.01680615,-0.12735246,0.09450303,-0.0011174615,0.03331694,0.03051591,-0.0618629,0.037782513,0.09009388,0.00612793,-0.07410071,0.13509461,0.012980634,-0.017658664,-0.032731608,-0.0021600362,0.014609429,-0.05182684,0.08310674,-0.021017183,0.043613933,0.013218869,-0.020987207,-0.006764486,0.005993914,0.03241134,-0.03143699,-0.08009991,-0.006749101,-0.06743975,0.054529645,0.07167942,-0.06949657,0.084673844,0.03310853,0.057402506,-0.030963328 +2.4.99.9,Lactose cannot act as acceptor. ,384,1.0,0.03591135,-0.108776845,-0.050580632,0.028637163,0.026479349,-0.034734286,-0.021679245,0.02910376,-0.02804195,-0.033293553,0.015007806,0.024075119,-0.09479385,0.051182278,0.0017091957,0.005671968,0.0074790213,-0.015786951,0.0059362603,0.04526612,0.066877976,-0.015254383,0.017578827,0.0063775913,0.042319003,-0.03592607,0.024444671,-0.06066932,-0.052080356,-0.08004118,-0.062534146,-0.120176986,-0.0070160935,0.029153088,0.02543351,0.018701768,0.035953075,-0.025103265,0.011134524,-0.08232938,-0.017749723,-0.03567374,0.029047105,-0.0008554222,-0.015173047,-0.011339623,0.021846218,0.004564855,-0.03456525,-0.013792344,-0.0922234,-0.033798426,0.022456488,-0.0006214653,-0.011200938,0.064957865,-0.024419473,-0.031964485,0.006536894,-0.014484374,-0.029811751,-0.013275421,0.032891423,0.04307885,0.039616983,-0.03925204,0.004698884,-0.050084095,-0.108728275,0.018742807,0.0012339416,-0.031250056,-0.03548192,0.021991944,0.087668106,0.044623323,-0.008131213,-0.014986065,0.08628599,0.1364457,-0.11489387,-0.080917634,0.016556863,0.042879492,-0.013941574,-0.07214836,-0.013883474,0.025136841,-0.048573494,0.014941459,-0.066037185,-0.0059654745,0.060630277,-0.04253714,0.059358627,-0.058907486,0.020826451,-0.014566254,-0.01937123,-0.03547791,-0.07297879,0.026011202,-0.009335744,0.0014207955,-0.053129677,0.033110853,0.014984521,-0.036681816,0.01967507,-0.020453809,-0.03612881,-0.012098259,0.11081326,0.0465777,-0.08655616,0.06693328,0.0002263402,-0.12528977,0.013975492,-0.011928152,-0.07891408,-0.0057234853,0.035119813,0.04252028,0.00059331895,-0.0027220952,0.05946746,-1.3012422e-33,-0.031351384,-0.03322903,0.068378374,-0.08221384,0.06335325,0.021242715,-0.049307555,-0.020702159,0.033076067,-0.009810951,-0.008858637,-0.039217256,0.055465337,0.0015819493,0.062538564,0.06529354,0.053908445,0.03541213,0.030955061,0.01966414,-0.03643991,0.037310086,-0.06445543,-0.0107683875,-0.08891429,0.0034406998,0.006518168,0.055865634,-0.018607985,-0.0047696056,0.05680996,-0.07669989,0.010192457,0.12160285,-0.003209038,0.022652429,-0.0073228506,0.026097042,-0.042597026,-0.0053451145,-0.05383201,0.028949026,-0.02191494,0.033091996,-0.0036404713,-0.016248679,0.047937542,-0.07517996,-0.06283549,0.0065136105,0.0028970095,0.0069713104,-0.06344288,-0.012567674,0.06355136,-0.012207635,0.012813312,0.112531826,0.012426114,0.024046049,0.008673601,0.050608665,0.02238479,-0.02265888,-0.019607754,0.057282764,-0.022770058,-0.056022543,-0.0066372687,0.07322756,-0.057426147,-0.041594587,-0.021086205,0.052476637,0.009932802,-0.09833515,-0.0031807567,0.014444699,0.044857994,-0.021113837,-0.034456432,-0.08778541,0.021077089,0.08401187,-0.081731394,0.029122695,-0.09125996,0.0014121888,0.04490494,0.05213651,0.06965278,0.0015327589,-0.022867195,0.03339139,0.093929015,-7.0363315e-34,0.07206203,-0.06270791,0.03250427,0.009118879,-0.007599531,0.039757356,0.03164776,0.007630263,0.14213021,-0.09696799,0.095164284,0.019174326,-0.026046831,-0.0015805204,-0.03145022,0.045584448,0.0013148854,0.076042436,-0.035816424,0.04557011,-0.01637372,0.1558048,-0.049470372,0.06671499,0.028400116,0.08265764,-0.035198618,0.016878301,0.007252375,-0.009529221,-0.0097246645,0.043541647,-0.034724515,-0.095048234,-0.041208606,-0.05390875,-0.12420596,0.009510158,-0.048944008,0.029242303,0.01646423,0.096995436,-0.01544853,0.055782393,0.023254264,0.03729776,0.06175687,-0.057659026,0.025826689,0.008644741,-0.051824998,0.0015570492,0.043504126,-0.011721278,0.09808902,0.100279056,0.07057374,-0.09695751,0.033182375,-0.0131110195,-0.008021913,0.00091048324,0.044619866,-0.07638107,0.039594695,-0.017540775,-0.11454387,0.015404268,0.07140901,-0.018234897,0.09901655,-0.02647672,0.059336226,0.115658365,0.020791275,0.009410816,-0.10444536,-0.012982167,-0.018378612,-0.067468435,-0.054649666,0.08294741,0.011966454,-0.031239877,0.12115208,-0.048024178,-0.031574078,-0.04571882,-0.007871198,0.038337536,-0.015665382,-0.06519324,0.018627102,0.038486563,0.04612626,-1.6296411e-08,-0.0012062583,-0.053640112,-0.018225767,-0.034384236,-0.06309224,0.058365647,0.01373101,-0.07894281,0.01853499,0.02572569,-0.046496507,0.14395988,0.00352137,-0.01076258,-0.019153683,-0.0010300757,-0.012406106,-0.053850587,-0.025549198,0.07855581,-0.16077188,-0.028836854,-0.07024735,0.00037707834,0.022233162,0.0057029664,-0.0018937584,0.063468926,-0.0010858112,-0.025250588,0.036856625,0.046167187,0.01745196,0.04221482,-0.04123721,-0.0005815057,0.01075294,-0.01469081,-0.05086124,-0.029426344,0.05376493,0.02389882,-0.056013577,-0.024814442,-0.05361582,0.068649374,0.005678786,-0.013022045,-0.07937554,0.03472866,0.020556547,-0.0007730687,-0.011981407,0.03730149,0.06516892,0.011501087,0.013863905,-0.04842175,-0.01813354,-0.024993068,0.10114123,-0.04453812,0.1773994,-0.05971486 +2.5.1.1,This enzyme will not accept larger prenyl diphosphates as efficient donors.,384,0.99999994,-0.06172311,-0.02817078,-0.03733242,-0.073559806,0.012952482,-0.10183995,-0.047260903,0.037459303,-0.036475163,-0.00801076,0.029393207,0.018797709,-0.06880765,0.05693735,-0.028245978,0.03813654,0.02921064,0.00094563595,-0.0029611427,0.03576617,0.07727242,-0.03161388,-0.0043141497,-0.04272798,0.047040097,0.004351618,-0.017376347,-0.041296657,0.044309184,-0.05197761,-0.07067179,-0.026165016,-0.025747774,-0.053853426,0.056421597,0.13890111,-0.086080156,-0.0065078246,-0.015545695,0.032467436,0.096950464,-0.015446505,0.0064504906,0.014801193,-0.10159223,-0.048821636,0.023505215,-0.010829487,0.026957946,-0.035869107,-0.080103256,-0.027188234,-0.009038845,-0.026805468,-0.011993193,-0.010059402,-0.084324986,0.024883017,-0.08324296,-0.020426495,-0.043842226,-0.008581158,-0.026957413,-0.028143125,0.12721854,-0.04851643,0.041444108,-0.025583073,0.0018498921,0.007914947,-0.007997536,-0.019531624,0.00889059,0.06781624,0.022205073,0.071324356,-0.056100734,0.032417934,0.048849978,-0.0076980977,-0.04345264,-0.066061996,0.021262,0.018151144,0.04187241,0.058849465,-0.023519805,0.03449043,0.006398618,0.034955177,0.019187797,0.030497316,0.0420671,-0.03801374,-0.07503019,0.039235104,-0.027766049,0.0029170539,-0.08753423,-0.013722675,0.079448104,0.083191395,-0.03632095,-0.05347405,-0.04360318,-0.020124868,-0.040569574,-0.0048137354,0.05132516,0.024004936,0.029568354,0.06327012,0.12904227,0.021783918,-0.06611368,0.12890473,-0.04379105,-0.066130996,-0.06916348,0.007189299,0.0052293628,-0.016436428,0.014655545,0.05123047,-0.024364326,0.05715396,-0.10391127,1.480219e-33,0.03619753,0.02615293,0.047512542,-0.04278113,-0.07975767,0.06070795,-0.068569206,-0.011078538,-0.05952177,-0.0244791,-0.04852843,-0.11716403,0.08925576,-0.01090778,-0.050279107,-0.027727861,0.046741717,0.020265322,0.10357106,0.014678536,0.047248982,-0.035980385,-0.06571796,0.027240546,0.030639956,0.008859783,-0.040395986,0.048868753,0.041130863,-0.0070063556,0.03856433,-0.08828798,-0.02668426,-0.010181345,-0.003725299,-0.03356416,-0.008863706,-0.05797443,-0.04984366,-0.024087794,0.015979774,0.043009326,0.032483958,0.027319895,0.086103655,-0.11221745,0.0116929775,-0.011419072,-0.085802,0.040212244,0.04413027,-0.031254627,0.050628774,-0.008903718,-0.033609737,0.009653327,0.044456027,0.0178616,0.021943724,0.01821349,-0.0039720396,0.0030847206,-0.06659519,0.037663497,-0.045284737,0.046094526,-0.0100899795,-0.05091786,-0.04295166,0.14931957,-0.017115504,-0.030534532,0.0006662028,0.050457966,-0.030805737,-0.06460137,0.025210498,0.06928288,0.10308059,-0.022432514,0.053117372,-0.07563313,0.00071634894,-0.013966083,-0.06490027,-0.04311505,-0.0046899375,-0.032907277,0.024626667,0.0024045177,0.10396791,-0.085361,-0.047876306,-0.04590951,-0.0151748555,-2.3880416e-33,0.09567659,-0.073268496,0.020506566,-0.05290051,-0.03728002,0.060122784,0.109545015,-0.031128341,0.0996768,-0.05916692,0.09958836,-0.034366976,0.08187971,-0.06629477,0.0316868,0.0363925,-0.070137866,0.02210476,0.030492535,-0.0076654656,-0.043212764,0.15737607,0.029743593,0.13041957,-0.015039957,0.00060734723,-0.08238013,0.038132865,0.013019515,0.041220065,-0.03578131,-0.0009631964,-0.09063361,-0.06550807,-0.04169679,-0.007890215,-0.037357356,0.0012889955,0.019639503,0.010353568,0.018900778,0.0049862475,0.00723617,0.028266644,-0.05671492,0.01788339,-0.0040630903,0.023247274,0.069781184,-0.037459254,-0.042046912,0.039832823,0.011907813,0.02589765,0.064804204,-0.008275958,0.038473666,-0.015347033,-0.014736257,-0.043323744,-0.033730645,-0.07343042,0.028080711,-0.027165286,0.03248189,0.060632225,0.013083458,0.13185067,0.029573627,0.0065316465,0.07180805,0.007840605,0.05831973,0.033393066,-0.007838712,0.02642902,-0.02276515,0.04789148,0.067093104,-0.07365314,-0.059779506,0.0899962,-0.01570817,-0.038332567,0.106887996,-0.031202797,0.05006674,0.026462544,-0.005681388,0.06284168,-0.058396723,-0.03258315,0.09652837,0.052943833,0.09899915,-2.1535719e-08,0.05129254,-0.0133966785,0.0014494475,-0.008109297,-0.012914402,0.014494018,-0.0551952,-0.033064146,0.029771244,0.062224206,-0.06483548,0.08760194,-0.0005163233,0.025514085,0.03379281,-0.037672404,-0.044342805,-0.009435034,-0.0649471,-0.092196584,-0.106713966,0.020030294,-0.07289401,0.03772485,0.03246525,-0.009719496,0.037551984,0.033137858,-0.01421429,-0.022065943,-0.03770117,0.010050591,-0.05779677,0.0015082977,-0.044258427,0.039749093,-0.015258096,0.06617791,-0.033051994,0.015103239,-0.047429148,-0.09499634,-0.07705033,-0.0059317835,-0.036357727,0.027052468,0.027153045,0.020390071,0.01315904,0.049028896,0.07242019,0.000725087,0.0015396755,-0.064780444,-0.019418191,0.019112473,-0.04487505,0.005906399,0.03271184,-0.07235867,0.08479331,-0.017978227,0.1163172,-0.054241385 +2.5.1.2,Various bases and thiol compounds can act instead of pyridine.,384,1.0,0.021441454,-0.07783437,-0.02989998,-0.043591645,0.044850357,0.026687177,-0.023246747,0.08076694,0.070134655,0.034017697,0.01433114,0.03564519,-0.09717981,0.06888553,0.06032619,-0.008114695,-0.072935544,0.05884156,0.07885004,0.034463663,0.017101653,0.012419273,0.010964802,0.032014083,-0.040365234,0.08274088,-0.014145329,0.116098635,-0.032093473,-0.07727229,-0.043909185,0.074830495,-0.0185952,-0.032691058,0.014531629,0.020643203,-0.18072298,0.12204325,-0.0061503993,-0.048699345,0.06987826,-0.109619334,0.023416396,0.02639002,-0.05116278,-0.0046073683,0.049305245,0.020558188,-0.021818418,0.0009364699,0.004814914,0.027078887,0.007959814,0.041760378,-0.061589263,0.013537853,-0.037265778,0.08216232,-0.043752026,-0.042329814,-0.021709234,0.01664125,-0.037093285,-0.04663458,-0.006565182,-0.0038015961,0.016185751,-0.0044311774,0.01399054,-0.001038375,0.00020055145,0.00020136259,0.03414005,0.0457994,0.06551868,0.05621891,-0.024041349,-0.042343784,-0.0051969774,0.014286035,-0.037740182,0.01110821,0.005426758,0.03785326,0.08742024,-0.024629949,-0.042216692,-0.010318788,-0.06252944,-0.046637896,0.04097911,0.059245855,0.035845272,0.025345644,-0.06490069,0.067576796,0.036558114,0.10460588,0.028216742,-0.06321344,0.013514448,0.014852203,-0.16494925,-0.048055705,-0.057228114,0.0046565905,0.024585837,-0.05898613,0.013872667,-0.06416954,-0.06658286,0.016199974,-0.023770839,0.021693991,-0.04048345,0.0020470766,0.052522793,0.017455105,-0.07991155,-0.011010691,-0.0318121,-0.00726496,0.01753817,0.057053126,-0.09179772,-0.06427265,-0.0051765633,9.586078e-34,0.046314426,0.07216334,0.058835328,-0.0050752903,0.0912393,0.0064919535,-0.071388304,-0.025124472,0.019379858,-0.025792304,-0.009660891,-0.032115456,0.016749622,-0.02551544,-0.016702695,-0.051943593,-0.06871889,0.042736847,0.1057069,-0.1054858,0.044914436,0.09077417,-0.07117514,0.049676653,-0.035299953,0.06832836,0.02764012,0.057435554,-0.026056012,-0.04029913,0.019610973,0.0025666466,-0.024153477,0.0008387323,-0.009102084,-0.000688822,-0.09740879,-0.01533355,-0.052000955,-0.024874989,-0.03972984,0.00056132907,-0.011707314,0.0009094575,-7.982307e-05,-0.06704949,-0.050244678,0.08169006,-0.022602836,0.035757627,0.06674269,-0.040352482,0.054291468,0.0003190978,-0.023364075,-0.009339149,0.0062385798,-0.028732682,0.012748698,0.008438543,0.07269141,0.024609271,-0.058458067,0.0054467735,-0.06854902,0.039712418,-0.01974614,-0.05186385,-0.024553768,0.074871205,-0.0036918514,0.03512645,0.012929766,0.03254398,0.008360112,0.020802768,-0.064632475,0.028837003,-0.005061596,0.02245689,0.0005878642,-0.053473804,-0.0038304573,0.0131086055,-0.038015466,-0.05932559,-0.0045634164,-0.028349359,0.039557554,0.040396474,0.017147308,-0.09734111,-0.027073268,-0.010285251,0.052208226,-1.607358e-33,0.015870415,-0.035192985,0.02069663,0.029041663,0.0035483905,0.00977661,0.07129777,-0.06269479,0.040540818,-0.03994208,0.054037075,-0.085534625,-0.05536381,-0.052464515,-0.03492895,-0.030847253,-0.01404094,0.020650798,0.004688642,0.013236652,-0.08450552,0.043426067,-0.12724252,0.068547845,0.04821713,0.05081092,-0.021450432,0.03338287,0.06250482,0.056593727,-0.026541015,0.033231147,-0.04018045,-0.01457491,0.03620205,0.060933754,-0.06570174,0.0038663116,-0.0053485865,-0.038271405,0.013711002,-0.015526009,0.09345298,0.048933275,0.034979112,0.07006702,0.020194335,-0.022331944,0.00011396196,-0.042676546,0.07403982,0.02414041,-0.06489576,-0.020134702,0.11149334,0.036063485,-0.017044729,-0.11663169,0.005041163,-0.09089271,-0.014425135,-0.0708969,-0.035545386,-0.02003345,-0.028606607,0.02190166,-0.071691126,0.043777574,0.09586134,-0.012924987,0.09304262,-0.0045777718,0.04929578,0.059384312,-0.06769927,-0.022564523,0.06750167,0.029353641,0.0046615056,-0.0054404936,0.011620469,-0.009684474,-0.0046700574,-0.11139971,-0.022084555,0.053856965,0.033840783,0.01593693,-0.021976396,0.025538046,0.0025629022,0.026528634,0.07216348,0.08367718,0.055020396,-2.0679783e-08,0.031685088,-0.028036492,0.07978721,-0.01639684,-0.009806009,-0.055024777,0.0979385,0.028610818,0.034809865,-0.022419252,-0.05063103,0.008564404,0.12213851,-0.018656347,0.09518903,0.069258705,-0.025353136,-0.012230207,-0.011929596,-0.019153463,-0.1488969,0.020447072,-0.1417742,-0.026086085,0.00031948302,0.0070508495,-0.032206517,-0.046020932,-0.0029506222,-0.0049306187,0.09495595,-0.052194424,0.041112185,0.024913622,0.016704552,0.012658576,-0.01688951,-0.059052996,-0.043110233,-0.040521275,-0.043511424,-0.0408781,-0.09095161,0.051478237,0.012675351,-0.042369712,-0.04860248,0.019341882,-0.069728814,0.018052973,0.055236824,0.06510255,0.00045110987,-0.06220965,-0.029486107,0.111152835,0.07772624,-0.054661702,-0.02853871,-0.10299942,0.031325683,-0.06841941,0.15061517,0.058405127 +2.5.1.3,"The enzyme catalyses the penultimate reaction in thiamine de novo biosynthesis, condensing the pyrimidine and thiazole components. The enzyme is thought to accept the product of EC 2.8.1.10, thiazole synthase, as its substrate. However, it has been shown that in some bacteria, such as Bacillus subtilis, an additional enzyme, thiazole tautomerase (EC 5.3.99.10) converts that compound into its tautomer 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate, and that it is the latter that serves as the substrate for the synthase. In addition to this activity, the enzyme participates in a salvage pathway, acting on 4-methyl-5-(2-phosphooxyethyl)thiazole, which is produced from thiamine degradation products. In yeast this activity is found in a bifunctional enzyme (THI6) and in the plant Arabidopsis thaliana the activity is part of a trifunctional enzyme (TH1).",384,1.0,-0.060925618,-0.023449901,-0.068258256,-0.0910503,0.040993877,0.0061715646,-0.05267678,0.042303115,-0.0035973822,0.060385723,0.035348427,-0.044486333,-0.037868995,-0.0040950486,-0.00781441,0.058956437,-0.07149549,0.0050016525,-0.061362993,-0.09078215,0.08418984,0.115399,0.007615225,-0.0081797335,-0.035585824,0.012061832,0.04707812,0.0002100038,-0.0345559,-0.09834469,-0.092291705,0.015128923,0.043272723,-0.04254788,0.029748088,0.10186397,-0.059355214,-0.033275347,0.08993347,-0.016413601,0.04170806,-0.03545772,-0.0861807,-0.037704375,-0.07925661,0.004979429,0.09615639,0.052674532,0.046941463,-0.015919492,-0.10713784,0.053479247,0.02137359,0.0055998615,-0.07295478,-0.00455944,0.0068676155,0.02366783,-0.054745257,-0.0009204284,0.020878587,-0.0652803,-0.0018650903,0.003906305,0.032661475,-0.011291202,0.031929854,-0.05631842,-0.013580022,-0.034102634,-0.08391471,-0.028536625,-0.018922172,0.044466868,0.007050406,0.038043328,0.065148555,-0.02797558,0.012358281,-0.011628814,0.014586904,0.010707372,0.050635263,0.022877151,0.033656895,-0.026377624,0.025206754,0.029081265,0.08484327,0.024199327,0.08099336,0.011708148,0.024977619,-0.0013561369,-0.020771174,0.062054347,-0.025722926,0.0019502419,0.075972274,-0.042191792,0.039088335,-0.008795531,-0.040254638,-0.023770437,0.0346234,0.036403757,0.06380286,0.03770089,0.020123886,0.03304542,-0.02241114,-0.007207447,0.049351234,-0.0004056183,-0.03992197,0.030826857,0.026538221,0.030780457,-0.038282763,-0.07704162,0.03163494,-0.010736492,0.07910961,0.03909004,-0.072041094,-0.0073394952,-0.1804452,1.8375774e-33,0.027210014,0.09776199,-0.008871297,-0.06351853,0.015561257,-0.009994928,-0.06573992,0.09247198,-0.04908077,-0.054572247,-0.09263319,-0.09728847,0.031457305,-0.018464586,-0.013587167,-0.098634675,-0.013065239,0.062506236,0.056922384,0.018657802,-0.011375749,0.009255007,-0.03659949,0.035354078,-0.035040252,0.05076065,0.1276087,0.050152738,-0.071216665,-0.036188014,0.0061570797,-0.12421665,-0.042063754,-0.05439786,0.078631565,-0.04829836,-0.03616869,0.05879044,-0.03604712,0.04220728,-0.046021212,0.06377043,-0.007417117,-0.0015009958,-0.029052231,-0.08197105,-0.06267672,0.071538836,0.05684883,0.01702442,-0.015153342,-0.049943242,0.1438595,-0.042461004,-0.022575429,-0.012341609,-0.014061225,-0.019347949,0.06670923,0.010311228,-0.054130007,0.02553574,-0.0435863,0.084041834,-0.070662975,0.016216615,-0.08955758,-0.07814737,0.03549338,0.06110592,-0.021781078,0.04441306,0.08520708,0.0074612405,0.05689588,-0.048156362,-0.04559788,-0.0147261545,0.048763987,0.015996033,0.04875923,0.0028029762,-0.031198524,-0.0075529255,-0.07134825,-0.03821152,-0.020791784,-0.016161188,0.005795964,0.04546314,0.061899893,-0.10504736,-0.03680873,0.027535189,0.068981126,-1.887862e-33,0.14384918,-0.015905295,0.075173296,-0.07670546,-0.028044581,0.00917927,0.023723269,-0.0036279017,0.0038926061,-0.03640271,0.03977326,0.0067961565,0.056634214,-0.014157111,-0.02102778,0.03656652,0.038625058,0.05131291,-0.01143414,-0.047587585,0.013194364,0.038091198,-0.039066497,-0.053936042,0.0074515594,0.026085915,0.011885608,0.10181785,0.017817331,0.022632042,-0.02390309,0.007786824,-0.033125017,-0.016228769,-0.023892641,0.043960523,-0.024486912,-0.0004969338,-0.0235982,0.007997727,0.034116987,0.050727222,0.036448684,0.05995756,-0.0038079678,0.05915016,-0.011274091,-0.02635735,-0.076578334,-0.035920657,0.06939393,0.030300394,-0.0065571805,0.018959094,0.08450793,0.033488374,-0.006545339,0.002844362,-0.027049646,-0.020198857,-0.0031492226,-0.07221163,0.08587133,-0.027435526,0.028778672,0.02641793,-0.041376136,0.0576452,0.045059837,0.039993808,0.07680958,0.011070975,0.015571322,-0.016823957,-0.053705286,0.035420127,-0.06381192,-0.042969696,-0.06171528,0.0121742,0.028528126,-0.080711335,-0.019983523,-0.04969328,-0.051732287,-0.056862526,0.09274229,0.11289173,-0.05473854,0.06970176,-0.05036528,-0.043912023,-0.019162275,0.11529472,0.06597402,-4.4931863e-08,-0.020568304,-0.06851987,-0.056898937,-0.04201264,0.014041833,0.040030237,-0.0045199846,0.04185334,0.13163617,-0.07201359,-0.0199811,0.054474533,-0.0048654196,0.050463475,0.052003913,0.016022777,-0.06264007,0.021565745,0.02175859,0.016643723,-0.035953704,-0.011537308,-0.16539305,0.04292925,0.024356628,-0.03488922,-0.0016484509,-0.015891531,-0.0062134867,-0.09959161,-0.023815818,0.0505252,0.027863994,-0.03002863,-0.051549297,0.005333469,-0.034463827,-0.050991666,-0.02257273,0.021739537,0.029757394,-0.0013501904,-0.103262685,0.04172946,0.024650633,-0.010115838,0.0042180154,0.06947509,-0.048709136,-0.08150327,-0.0006266643,0.043241035,0.020961117,-0.04673594,-0.03184083,0.057975486,0.008145302,-0.0039704647,-0.027821166,0.03209691,0.056586754,-5.509133e-05,0.14474289,-0.08144161 +2.5.1.9,A flavoprotein (riboflavin).,384,1.0,0.004612328,-0.050849855,-0.14403366,0.071189865,0.009937108,0.06551402,0.010759261,0.0815245,0.046370342,-0.04328857,-0.002521508,0.017687391,-0.064226784,0.03345419,-0.11115331,0.004281927,-0.03751029,-0.004044177,-0.035717253,-0.010722811,-0.09590225,0.054281455,0.061578795,-0.006300214,0.0031921123,-0.014196115,-0.01884956,-0.02690306,-0.010913954,-0.0015102304,0.03612391,0.049735904,0.07681718,0.0019879655,-0.030123541,0.027870616,-0.00241544,-0.070755355,0.0052597723,0.01595719,0.016473653,-0.01791413,0.0050967233,0.032163277,0.05257264,0.02399302,-0.06380264,0.1556343,0.06473702,0.09721986,-0.06958228,-0.049673654,-0.081034414,-0.014879409,0.071070254,-0.034554653,0.0016922657,-0.052003436,0.013225125,0.040180348,-0.023894051,-0.054740172,0.049209308,0.019709848,0.03476098,-0.0752443,0.022833677,0.022878181,0.05727987,-0.020615533,0.04554814,-0.0021981841,-0.06891791,0.09059664,-0.043390084,0.023988565,-0.042559132,-0.012350347,0.061394144,0.0010090779,0.07017797,-0.017440598,0.015895456,0.05620242,0.015865367,0.00023754466,-0.044594258,0.04028269,-0.048789967,0.057007555,-0.016743973,0.039596405,0.03624438,-0.027100958,-0.02978912,0.022329073,0.049168784,-0.03928849,-0.1061671,0.02226709,-0.054940894,-0.05423325,0.054428514,-0.009475821,-0.059801996,-0.011003506,-0.026370125,-0.0039752186,-0.029327415,-0.04220632,0.020714602,-0.029938497,-0.02602173,-0.07214416,0.04070409,0.04507768,0.04287944,-0.0023685948,-0.053937193,0.058833864,-0.041588623,0.090244964,0.043547448,0.062549055,-0.038029067,-0.034031898,-0.029806491,-1.1477463e-33,0.08569922,-0.013322201,9.58581e-05,0.059548266,0.015976526,0.011610493,-0.048538286,0.016003225,0.035138518,0.0050362446,-0.089755334,-0.022228954,0.049748965,-0.082056075,0.0640306,-0.008196513,-0.026017472,-0.047009625,0.014778291,-0.04705003,-0.021009723,0.07908904,0.004140502,0.06381236,0.0017230848,0.011605667,-0.028053667,-0.06904855,0.02307567,0.0067067808,-0.0060127242,-0.031330198,-0.048251163,-0.020600336,-0.03578864,-0.02318323,-0.0709669,-0.10335923,-0.06364482,0.07551881,0.031954657,-0.06402354,-0.042127483,-0.0010779876,0.018488653,-0.013250015,-0.065413386,0.043574784,-0.052358605,0.02209117,0.066939265,-0.027576122,0.08429165,0.044869248,-0.07552564,0.029250948,0.014272977,0.023812778,0.047089994,0.019590236,0.019806845,0.025494827,-0.03703988,0.012393594,-0.11822795,-0.05517952,-0.0713739,-0.09630372,0.008225665,-0.011756088,0.09341544,-0.043277856,0.10137818,0.01201326,0.0096887965,0.025734326,-0.06412564,0.00020919689,-0.04052347,0.020783361,-0.06963459,0.013840928,0.019731926,0.027953368,-0.03981701,0.04787727,0.0037360413,-0.057395432,0.00769094,-0.022369381,-0.0077378745,-0.033980876,-0.022947589,-0.04274478,0.06934562,-2.0041352e-34,0.038865242,-0.14321233,-0.022485618,0.05148762,0.007615758,0.0074657924,-0.028804736,-0.049394153,-0.026044693,-0.0038739275,0.051918812,-0.08803389,0.004528451,-0.014213593,0.028943269,0.090976104,-0.000990226,0.059285372,-0.0045615723,0.029315524,-0.086025,-0.0728088,0.083475076,0.09152596,0.01924081,0.033949148,0.07680513,-0.12542795,-0.018951043,0.071539536,-0.07039591,0.006776159,-0.062324945,-0.046686925,-0.00725741,0.06567278,0.02072742,-0.04588539,-0.030426733,0.031306103,-0.079057865,0.08625506,0.033373445,0.056163058,0.07414483,0.05322363,0.04176612,0.01812837,0.015596457,-0.041577153,0.028821956,0.05322252,0.002312511,0.12425715,0.001164902,0.025042687,0.053782206,0.017665027,0.034895893,0.041867867,-0.0010999246,-0.09440506,-0.035430003,0.006396178,0.084975496,0.07096467,0.011793895,0.042004228,0.03938874,-0.0779056,0.08742037,-0.047819424,0.05543861,0.09169199,0.023091651,-0.0018172046,-0.020555414,0.043728217,-0.033076026,-0.015627153,-0.067228876,-0.023379564,-0.019800212,0.024846828,-0.016048633,-0.18576477,0.034369733,0.023771891,-0.012505283,0.02939791,-0.016279522,0.053867895,-0.05634223,-0.022573275,0.05266272,-1.8336998e-08,0.023370313,-0.0118591385,-0.027001185,-0.04833494,0.09372756,-0.016336773,-0.02016946,-0.013894953,0.0109009035,-0.020751424,-0.044392847,0.0873166,-0.013591492,-0.003745845,0.045472298,0.0069639226,-0.013554226,-0.01773657,0.005843938,0.023476975,0.014492562,0.02226687,-0.034540858,-0.008819078,-0.13044105,-0.031768467,-0.032291736,-0.010344338,0.122489765,-0.033382334,0.052075844,0.09842519,0.018298304,-0.09181936,-0.12916178,0.036207393,0.10539225,-0.043940987,-0.025271297,0.052158937,-0.13378087,-0.042091873,-0.023248358,-0.042781886,-0.017519163,-0.05347773,0.039602242,0.03470828,0.02369516,-0.035783656,0.04429552,0.06046236,-0.0014569615,0.031494737,-0.037866198,-0.023357105,0.0002252684,-0.047473922,0.019671744,-0.07202098,-0.05646949,-0.01763087,0.10850123,0.022237709 +2.5.1.10,Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors.,384,1.0,-0.06886626,-0.05743803,-0.01190444,-0.087123215,0.0019203853,-0.058601532,-0.026218258,0.061664067,-0.008574827,-0.023142347,0.0123075,-0.021813082,-0.08128025,0.07392062,0.02869432,0.0090229,0.024217969,0.012881462,0.0005424099,0.013926639,0.08202479,-0.042497337,-0.033634618,-0.052927777,0.02527077,-0.0292511,0.02682034,0.013883031,0.08754813,-0.043316532,-0.08330273,0.012796787,-0.0042219064,-0.07344777,0.018875515,0.13273884,-0.10145223,0.002223094,-0.043185223,0.020574385,0.099821456,-0.052260403,0.0031462384,0.027084721,-0.12582183,-0.06919038,0.02109927,0.01465089,0.026985036,-0.022949921,-0.056286324,-0.026721008,0.006213644,-0.033852614,-0.010407825,-0.024699243,-0.062945016,0.028396664,-0.06857135,-0.007548493,-0.040170502,-0.0050602346,-0.030232243,-0.07007737,0.09774234,-0.05092451,0.04095984,-0.048923384,0.0075471117,-0.018505607,-0.0072811935,-0.017063653,0.02803839,0.058690313,-0.01269577,0.06735823,-0.015880927,0.02578454,0.05818919,-0.03103426,-0.008718149,-0.012367442,0.0019980206,0.005363218,0.046784606,0.078757055,-0.046619173,0.020259248,0.02361255,0.00775042,0.033723425,0.0381864,-0.030448584,-0.05698435,-0.07042739,0.047365993,-0.037251145,0.036436297,-0.03432271,-0.009951794,0.101391256,0.060888946,-0.06343309,-0.044263165,-0.061210778,-0.0005677752,-0.048094478,0.014707167,0.025754558,0.0340473,0.02260977,0.04574672,0.10809121,0.047350552,-0.0541692,0.089066654,-0.081952944,-0.08889654,-0.05691596,0.0051467074,0.031465877,-0.037874997,0.032927122,0.074336655,-0.0147436755,0.055538956,-0.08133581,3.1287354e-33,0.03701549,0.079945385,0.026594322,-0.05368723,-0.08977429,0.03849609,-0.057892174,0.013689114,-0.07623086,-0.034063738,-0.056407347,-0.09754543,0.0791963,0.04976954,-0.06172601,-0.01911899,0.022276876,0.030954607,0.0965093,0.034007274,0.05968227,-0.002350741,-0.04291487,0.02325531,0.02514537,-0.007539529,-0.055308435,0.06596509,0.040598396,0.0043416554,0.04136284,-0.12257963,-0.03727635,-0.020862939,0.0073350426,-0.037117057,-0.009374583,-0.047724955,-0.063990965,-0.023443472,0.023942858,0.003038122,0.043255333,0.040395398,0.051105194,-0.087168455,-0.024626119,0.008683718,-0.0423287,0.014548378,0.052603617,-0.034394726,0.06402439,-0.053063802,-0.04741943,0.03478757,0.012743949,-0.0024628786,0.043733638,0.019717714,-0.031898607,0.0014669165,-0.081303924,0.030509451,-0.030241894,0.03261858,-0.011688619,-0.0495301,-0.040100217,0.118038155,0.009083017,-0.011152165,-0.012840032,0.059786823,-0.0024077308,-0.063549146,0.03431564,0.065223165,0.107811116,0.0014616436,0.05817549,-0.07266666,-0.009784349,-0.061385233,-0.07223318,-0.045219474,0.028690487,-0.078189164,0.004214257,-0.0040960647,0.073113404,-0.09920796,-0.0554657,-0.031724043,-0.025318258,-5.0876464e-33,0.10020095,-0.052996423,-0.0071863676,-0.08458839,-0.053556632,0.059654076,0.123352386,-0.051684245,0.06507004,-0.046316717,0.055374313,-0.03599995,0.032412432,-0.05488721,0.008143185,0.06360612,-0.09005346,0.016004778,0.040526923,-0.006667776,-0.07320208,0.1309085,0.051548164,0.11381523,-0.0069097206,-0.030054292,-0.071299985,0.054936644,0.0038497534,0.07226074,-0.022142334,-0.024186168,-0.045480113,-0.046676796,-0.04298018,0.009467026,-0.033516955,-0.041017223,0.045290336,0.013498208,-0.023946606,-0.0019124552,0.03566206,0.012017156,-0.06614879,0.03659798,-0.015362087,0.01736993,0.037188064,-0.08160118,-0.0066312407,0.05402387,0.004696459,0.036963,0.03967608,0.041630242,-0.004056462,-0.0003964194,0.0051445537,-0.058888514,-0.045708217,-0.097258784,0.03194188,-0.048185825,0.0602509,0.06558873,0.00482272,0.087014474,-0.021061458,0.027968198,0.040293004,0.028317979,0.0118877,0.044457324,-0.03059812,0.027891599,-0.02815885,0.061353076,0.0366119,-0.053715654,-0.014329735,0.059053842,-0.054664828,-0.044849265,0.06413183,-0.02714531,0.08906463,0.0834142,0.014397759,0.039471827,-0.04646968,-0.018433029,0.04650573,0.08257178,0.12155211,-3.285514e-08,0.050755348,-0.03560932,0.0021395676,-0.044289496,-0.03675753,0.00062596175,-0.014214346,-0.031004682,0.033860274,0.07704037,-0.096443586,0.08577466,-0.00987039,0.024177447,0.048708316,-0.03093103,-0.05975284,0.009285485,-0.060774397,-0.09654636,-0.04536966,-0.0014330033,-0.097707525,0.01842462,0.029635392,-0.0013293502,0.03866472,0.040091515,-0.007903337,-0.0013008487,-0.038050883,0.03471293,-0.061016593,-0.033978295,-0.020561848,0.07037479,-0.05429573,0.033904202,-0.008196346,0.03570594,-0.027488,-0.09991802,-0.05420954,-0.011849065,0.012865757,0.034066692,0.0016932403,0.03752043,0.031348094,0.05339458,0.02334868,-0.016177263,-0.0072422717,-0.092131205,-0.031609107,0.0030247513,-0.06807554,-0.012623502,0.04254032,-0.06576824,0.060186204,0.044074185,0.16928333,-0.064619355 +2.5.1.11,"This enzyme will also use geranyl diphosphate and all-trans-prenyl diphosphates of intermediate size as donors, but not dimethylallyl diphosphate.",384,1.0,-0.044859815,-0.021081798,-0.056561753,-0.09767551,0.0042540217,-0.044581074,-0.042949237,0.062881105,0.006954911,-0.05562437,0.049972665,-0.015154236,-0.07433766,0.078562535,0.008154423,0.022360161,0.010027603,0.032831855,0.030179664,-0.022503005,0.070985496,0.015928924,-0.019961629,-0.03588782,0.069019005,-0.023139631,0.03157435,-0.0008987577,0.08573161,-0.03853232,-0.08978751,-0.0064276,-0.026515845,-0.042036146,0.03255759,0.10444212,-0.08826753,-0.013642006,0.002992147,0.047876284,0.09420566,-0.028525194,-0.0024217593,0.016112972,-0.09378704,-0.03889893,-0.004551277,0.013752629,0.0023964741,0.002428572,-0.0544229,-0.04654384,0.0058814124,-0.008858103,0.035097513,-0.0205827,-0.036170296,-0.0061385087,-0.05018722,0.0030952657,-0.0400616,0.00014602621,-0.04365679,-0.05972451,0.038489923,-0.03146227,0.0710858,-0.03873146,0.021650558,-0.0545725,-0.04357046,-0.033905577,0.059888337,0.06183467,-0.034399223,0.06115428,-0.03141823,0.051451664,0.05195312,-0.044701573,-0.0030276072,-0.0073268753,0.0026444588,0.010989296,0.05976887,0.07788214,-0.04549792,0.08433928,0.02822848,0.017424455,0.028294068,0.011148969,-0.03336692,-0.10449722,-0.08019829,0.052064214,-0.040381357,0.012931001,-0.024678156,-0.044250876,0.08500214,0.028483186,-0.02156324,-0.056740876,-0.060970854,0.020724004,-0.034540165,0.038706865,0.02307243,-0.010358363,-0.022070156,0.038429085,0.10984757,0.014684343,-0.049480516,0.08665666,-0.068303436,-0.08184686,-0.038860753,0.02732859,0.026085116,-0.05043899,0.046331894,0.08650235,-0.035802957,0.07119537,-0.07597311,3.7628555e-33,0.04053841,0.070281796,0.017429214,-0.010969854,-0.07760679,0.05663566,-0.06165131,0.021448404,-0.09374488,-0.033248298,-0.05211097,-0.0886329,0.067743085,0.039879758,-0.08147415,0.014230553,0.03344095,0.000108756234,0.09762412,-0.011142559,0.06382838,0.07540066,-0.060359567,0.048026625,0.0052385055,0.0030867516,-0.04318179,0.046501126,0.03233031,-0.003542361,0.046312205,-0.11759142,-0.0539353,-0.0063679274,0.01534562,-0.046117272,-0.026402269,-0.07928459,-0.04831285,-0.009449988,0.035429902,0.015232526,0.030784955,0.026593322,0.05617569,-0.09967283,-0.040387042,0.044511925,0.0026285648,0.023368383,0.06480675,-0.012480162,0.037865058,-0.08889212,-0.053616084,0.050503157,0.0074497066,0.04114218,0.057939712,0.020131337,-0.035824776,-0.016335292,-0.08366241,-0.012824252,0.03380779,0.039067235,-0.040590618,-0.06911703,-0.045546606,0.15379567,0.0042401096,-0.0345872,0.022051463,0.1272431,-0.002829598,-0.05212778,-0.0028285433,0.013780164,0.094787896,0.022244839,0.025168743,-0.057539143,0.0190582,-0.04782859,-0.04864768,-0.03214109,0.023550902,-0.08285853,-0.026434653,0.009692938,0.06408507,-0.07724375,-0.06640186,-0.014359157,-0.013220134,-5.110487e-33,0.10662575,-0.030806525,-0.013082456,-0.06404371,-0.06340373,0.05571379,0.11084307,-0.07560046,0.088288255,-0.020827992,0.1017954,-0.039402932,0.007406396,-0.053393275,0.014437419,0.06916577,-0.06618162,-0.002524543,0.025085725,0.017694874,-0.05316265,0.1271242,0.070359804,0.0719351,0.028626518,-0.020787796,-0.06101186,0.08251902,-0.0069203605,0.07521669,-0.049457174,-0.026098758,-0.06018925,-0.08683939,-0.07861935,-0.018500488,-0.04007915,-0.026119659,0.03080822,0.009201158,-0.036036585,0.001998303,0.03457481,0.056226693,-0.059047446,0.06317287,-0.036518276,0.011448746,0.023241287,-0.10265055,-0.029846856,0.057695,-0.0051304335,0.0034450395,0.03406406,0.03282381,0.01373644,-0.0047165444,-0.011000805,-0.07672501,-0.035147984,-0.07828285,0.040559698,-0.06887886,0.023812557,0.101389445,0.018108632,0.057597887,-0.018540883,-0.0009601067,0.02681813,0.049351227,0.030063055,0.008187999,-0.06955824,0.0178874,-0.038590636,0.019515306,0.05772731,-0.06585183,0.023550339,0.030824563,-0.064151086,-0.029693486,0.03610944,-0.032235462,0.061661456,0.093384996,0.037549555,0.03958844,-0.054760654,0.030888235,0.0389157,0.0325229,0.13349047,-3.4015883e-08,0.033075053,-0.015603216,0.033901885,-0.054989476,-0.037506923,0.019488236,-0.010417994,-0.008180135,0.014524001,0.07665671,-0.06754599,0.08821764,-0.022919267,0.019448418,0.028975544,-0.03946336,-0.03652243,0.030581819,-0.058970053,-0.09050819,-0.048357636,0.017676929,-0.049646623,0.039509945,0.04640024,-0.020730805,0.03886129,0.02182303,0.032246556,-0.03675775,-0.016660418,-0.0118035795,-0.025038548,-0.052736662,-0.019585157,0.1020349,-0.049625717,0.026808301,-0.023577964,0.035851594,-0.0010145616,-0.09887082,-0.074280396,0.023408141,-0.01164729,0.02444199,0.005267291,0.013926504,0.012345016,0.025461115,0.073290095,-0.028433837,-0.017976271,-0.06039638,-0.03848152,-0.0069833533,-0.04201507,-0.04205673,0.046453632,-0.06990209,0.05466607,0.03872012,0.16055231,-0.056355488 +2.5.1.15,"The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [4], while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25, dihydroneopterin aldolase [3]. ",384,1.0,-0.04485569,-0.07670867,-0.06706863,-0.05422597,0.08041759,0.042169403,-0.099609196,0.041423514,0.07585545,0.012074369,0.01040357,-0.07390394,-0.11773336,0.015157094,-0.03214263,0.06914596,-0.09332534,-0.02486307,-0.022085732,-0.04609977,0.044602722,0.048555657,-0.040788684,0.015991714,0.0011307355,-0.046923365,0.024006767,-0.0427609,-0.0658585,-0.07164166,-0.0042418377,-0.007852395,0.058700617,0.026760299,-0.014613455,0.17707868,0.012712849,-0.09737,0.05272608,0.029056799,0.021847405,-0.04099703,-0.040497597,-0.026171602,-0.036330115,0.0054750014,0.049129024,0.00056416896,0.07176941,0.027937504,-0.03871974,-0.040242318,0.01836466,0.021325178,0.01861629,-0.026523808,-0.0072336216,0.03599624,-0.012502259,0.07394955,0.035736028,-0.027303176,0.029843317,0.015529771,0.021886686,-0.060389243,0.0023118241,-0.07195956,0.03567418,-0.08124257,-0.048600852,-0.051186077,-0.01430449,-0.029027756,0.009961762,0.016656974,-0.034911092,-0.007978078,0.013643261,-0.052127153,0.08640138,0.05098681,0.010483977,0.04758504,0.067214325,-0.07684077,-0.020032868,0.030447477,0.03884028,-0.023819908,0.058790527,-0.034237586,-0.043729592,0.029454282,-0.074589975,0.016232902,0.010019639,-0.012924176,-0.0121219065,-0.026844664,-0.025904296,0.07373111,-0.04594884,-0.07575267,-0.011719751,0.010098044,0.015852433,0.11280951,-0.0136403795,0.013500843,0.02727268,-0.015944866,0.03701296,0.06555327,-0.012574234,0.039846282,-0.0024860695,-0.09044981,-0.0149906995,-0.002923082,-0.010025363,0.0030246135,0.11743766,0.052567914,-0.058923528,0.035436463,-0.15458903,2.869272e-33,0.08101767,0.017713038,-0.050984718,-0.0017460623,0.028684713,-0.02132208,-0.058479745,0.0986863,-0.016911546,-0.0424675,-0.03779663,-0.019354435,0.09077865,0.037642665,-0.018857336,-0.04276566,0.00082400115,-0.052548878,0.07934633,0.0067213653,0.029023893,-0.010804951,-0.06808582,0.03785358,0.059213072,0.02768158,-0.0033389525,0.02524378,0.045345757,-0.025249397,-0.0513011,-0.11577658,-0.08617215,0.0048468895,0.07543734,-0.0073462087,-0.03360184,-0.0038964902,-0.07720938,0.03295896,-0.03961319,0.0029723456,0.014694071,-0.107968405,0.056945458,-0.011495997,-0.048756104,0.080844834,0.054555744,0.06113408,0.03490989,-0.029688792,0.14590776,-0.006454317,-0.030078579,0.0047990847,-0.033730973,-0.015513901,0.014174015,0.05882572,-0.057911083,0.023486272,-0.020283513,0.03560353,-0.022174785,0.042912204,-0.08079945,-0.042695887,-0.009781511,0.106173605,-0.05215763,0.008603978,0.07226671,-0.017569568,0.0029440988,-0.06968341,-0.07938092,-0.014891669,0.008536669,0.06478267,0.078200996,-0.05124235,0.019001558,-0.0010191603,-0.08515699,0.013403317,0.024581477,-0.04000643,0.006718532,0.0022307516,-0.0047981204,-0.03401385,-0.034616526,0.00960413,0.09102396,-3.891686e-33,0.10773361,-0.062047552,0.061233904,-0.077308804,-0.025135163,0.122467935,0.023914775,-0.036776483,-0.00032176528,-0.045640323,0.069727816,-0.01652949,0.035640705,-0.05654064,-0.0042554648,0.034461766,-0.07942358,0.040765148,0.014778812,0.015354618,-0.008207206,0.07316664,-0.0060706404,-0.004556362,0.098052844,-0.0154722445,0.010098027,0.105103604,0.010938774,0.0075232284,-0.04620955,0.019924203,-0.047054965,-0.036080025,-0.05315659,0.047002677,-0.10398733,-0.003588261,0.018238623,0.036975916,0.048978865,0.06644146,0.015756834,0.056088038,0.023871938,0.097875826,-0.06918269,0.031894226,-0.016545178,-0.021369252,-0.004465615,-0.036378488,-0.068208046,0.06519073,0.047237385,0.044139363,0.022752313,0.061754543,-0.006966128,-0.02194802,-0.004157665,-0.09961354,0.04076487,0.020766526,0.021354306,0.00793299,-0.050989833,0.04039517,0.034642767,0.09744135,0.092877306,-0.037286635,0.050425045,0.06171567,-0.019517208,0.0023371486,-0.044061102,-0.040492713,-0.035082866,-0.015753169,0.030447802,-0.019667283,0.012197328,-0.047521394,-0.023929905,-0.016073117,0.058322467,0.07020822,-0.038604017,0.031198071,-0.012598799,-0.004802907,-0.05167623,0.008379124,0.05072353,-4.625744e-08,0.052235235,-0.03475326,0.021353895,-0.09453411,0.02493259,-0.001644687,0.080132775,0.04274217,-0.039645582,-0.024078136,-0.056448266,0.035930075,0.0044694985,0.026601704,0.052346446,-0.033663347,0.015551274,0.053843714,-0.011100206,0.053878523,-0.010633091,-0.031820692,-0.13481553,0.042875435,-0.028600758,-0.06826943,0.007194241,0.037919547,0.020157415,-0.0146466745,-0.02853377,0.052583247,0.030330364,-0.09144081,-0.1013324,0.05100495,-0.0767624,-0.04039629,-0.088579215,0.0037665386,0.023487518,-0.052668743,-0.08638256,-0.008900404,-0.005275865,-0.017229207,0.04219351,0.04275104,0.031461306,0.04565269,0.059529684,0.022172121,0.027827635,-0.035101786,-0.08742715,-0.011277222,-0.045404878,-0.06726585,-0.018844772,-0.05836595,0.023502158,-0.057826314,0.1651714,-0.08707548 +2.5.1.16,"The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor [2,7]. The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant towards other amine acceptors, such as spermidine and cadaverine [5,6]. cf. EC 2.5.1.22 (spermine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).",384,1.0,-0.040241074,-0.08046274,-0.11443105,-0.12431171,-0.0055732713,0.09041555,-0.11733589,0.051773846,0.011839272,0.06392109,0.07081934,0.048505627,-0.04306479,0.09768649,-0.00960088,0.01116602,0.0073628523,-0.0150871165,-0.009815562,-0.015093915,0.032377966,0.11178037,-0.06144122,-0.01587194,-0.010918901,-0.037574314,-0.06288129,0.0054352744,0.04072253,-0.036464456,-0.08587717,-0.057129268,0.01935945,-0.10747759,-0.0036200695,0.042722985,-0.03241557,-0.035673387,0.073543966,0.017032493,0.0066837627,-0.0028478724,-0.004828239,-0.028788751,-0.06679991,-0.0201612,0.121065654,-0.0396229,0.06493505,-0.02281607,-0.03608326,0.0006705721,-0.028835397,-0.008367437,0.02459768,-0.06734465,-0.07247581,-0.003028027,-0.05009202,0.002138883,-0.02778646,0.017952861,0.010913306,-0.033558637,0.039456952,-0.04850432,-0.016790258,-0.042929377,-0.02816608,-0.064362034,0.03969098,-0.10171095,0.009591294,0.056167975,-0.061076067,0.029347956,-0.046932444,0.06856726,0.040138237,0.007477628,-0.016465176,-0.099116735,-0.07312012,0.03691659,-0.01882165,0.043363918,-0.033663016,0.13006818,0.052967615,0.02644931,0.049588747,-0.0069730002,0.012224646,-0.059760176,-0.0021518997,-0.018214408,-0.026251111,-0.0010698347,-0.0063125202,-0.058829166,-0.030097341,0.01997551,-0.054700512,-0.038614072,-0.030718515,-0.018499132,0.0069878185,0.02542188,0.030165173,0.013696608,-0.0038713964,0.051753744,0.020544084,0.052283607,-0.019023549,0.05061883,0.035452474,-0.08416878,-0.0063724993,-0.09020306,-0.013266234,0.036929753,0.079599276,0.11129299,0.00994663,0.06012348,-0.04278287,5.135517e-34,0.069352604,0.01815476,0.063130684,-0.015089332,0.030676471,0.09223396,-0.07275952,0.072769016,0.05179879,-0.09062913,-0.122721285,-0.070219696,0.040131267,0.013792594,-0.003086516,-0.0048692077,0.007310798,-0.0418177,0.019424805,-0.018913481,0.0558522,0.053720165,-0.012324967,0.04905456,0.059663516,0.0043796957,0.05739756,-0.037196085,0.010217166,-0.04238837,0.009948923,-0.119710445,-0.06809359,-0.022402618,0.044435594,-0.026780492,-0.06593492,-0.01198066,0.038850196,0.030398004,0.066990115,0.024285335,-0.0013366346,0.029687777,0.086820036,0.020917399,-0.029333439,0.08730444,-0.04319968,0.026760887,0.0010472109,-0.025761928,0.04036553,0.026750643,-0.09681871,0.01963354,0.031219132,0.038194284,-0.059110533,0.05544227,-0.002124506,0.009096388,0.023647498,-0.013767676,0.019872684,0.0048288736,-0.13676737,-0.020929946,0.055280603,0.12381405,-0.038166463,-0.034187738,0.02474343,-0.0052293995,-0.0062135397,-0.10394769,-0.066704445,0.058150884,0.05521132,-0.037226778,0.009432298,0.055230774,-0.07433832,0.0443075,-0.086882494,0.00856834,0.013849977,-0.048766285,0.039954215,0.016441729,0.08675178,-0.06281539,0.01568669,-0.009061521,0.020474289,-1.6542596e-33,0.06537427,-0.16057457,0.09762982,0.005198877,0.031148555,-0.00054324494,0.014640061,0.0031737862,0.021688338,-0.08550518,0.009019939,0.023431407,0.0834267,-0.037219916,-0.009479629,-0.011908034,-0.03162176,0.025547726,0.008266999,-0.07222903,-0.06228968,0.005290768,-0.0029620966,-0.015415538,0.094505645,0.026273921,-0.019654257,0.07293007,0.015142854,0.02493789,0.021854332,0.06575358,-0.09041302,-0.026859118,0.0033470546,0.043497387,-0.044646297,0.047889084,0.0030355619,0.01195332,0.015014849,0.053097516,-0.025911458,0.13470745,0.01345147,0.04935544,-0.05074003,0.002657308,-0.03685006,0.009801773,-0.00068013533,-0.06440415,-0.012969337,-0.011524866,0.07532985,-0.02543479,0.021430682,-0.028631201,-0.041838747,-0.006798653,0.012504247,-0.038592797,-0.02772054,0.033026297,-0.027474156,-0.0066623664,-0.017173978,0.0658281,0.048231617,0.039333288,0.061879944,-0.10600381,0.087014355,0.0625221,0.01280735,0.017126532,-0.039263196,-0.042131692,0.050208177,-0.039831605,-0.093185104,0.025513472,-0.04633837,0.07922023,0.052415732,0.0069704386,0.065690175,0.11987692,0.0068246694,0.03635857,-0.07291533,0.007817734,0.015552519,0.07201185,0.050599214,-3.9676863e-08,0.065429546,-0.090073645,0.024863802,0.002195793,-0.045369774,0.05504366,-0.038848158,0.016379569,0.06506674,-0.0017462409,-0.04362632,0.007161008,-0.038487557,-0.006692833,0.006041341,0.046447873,0.0063188397,0.012399325,-0.029670114,0.0082719,-0.12605871,0.023263426,-0.14803751,0.0020186463,-0.045448154,-0.014910349,-0.031886656,0.05726177,0.015930835,-0.02227438,0.030813485,-0.039000522,0.026013495,-0.06758267,-0.04726263,-0.009928313,0.030490726,0.0013449786,0.028159825,-0.046399433,0.044612188,-0.08775063,-0.052760404,0.0009297681,0.045854714,-0.015603579,0.020548955,0.032776557,-0.02072932,0.0081549,-0.017298002,0.033411358,0.05486489,-0.05291267,-0.05185373,-0.020956008,-0.087984614,-0.03913,0.0109554725,-0.0042804717,-0.006221884,0.030894127,0.15870693,0.014341773 +2.5.1.17,"The corrinoid adenosylation pathway comprises three steps: (i) reduction of Co(III) within the corrinoid to Co(II) by a one-electron transfer. This can occur non-enzymically in the presence of dihydroflavin nucleotides or reduced flavoproteins [3]. (ii) Co(II) is bound by corrinoid adenosyltransferase, resulting in displacement of the lower axial ligand by an aromatic residue. The reduction potential of the 4-coordinate Co(II) intermediate is raised by ~250 mV compared with the free compound, bringing it to within physiological range. This is followed by a second single-electron transfer from either free dihydroflavins or the reduced flavin cofactor of flavoproteins, resulting in reduction to Co(I) [7]. (iii) the Co(I) conducts a nucleophilic attack on the adenosyl moiety of ATP, resulting in transfer of the deoxyadenosyl group and oxidation of the cobalt atom to Co(III) state. Three types of corrinoid adenosyltransferases, not related by sequence, have been described. In the anaerobic bacterium Salmonella enterica they are encoded by the cobA gene (a housekeeping enzyme involved in both the de novo biosynthesis and the salvage of adenosylcobalamin), the pduO gene (involved in (S)-propane-1,2-diol utilization), and the eutT gene (involved in ethanolamine utilization). Since EutT hydrolyses triphosphate to diphosphate and phosphate during catalysis, it is classified as a separate enzyme. The mammalian enzyme belongs to the PduO type. The enzyme can act on other corrinoids, such as cob(II)inamide.",384,1.0,0.006958489,0.001517614,-0.08647154,-0.0032903042,0.041828606,-0.022641087,-0.051507145,-0.01932122,0.084604055,0.04145438,-0.00040701104,-0.018557023,-0.097605705,0.005168886,-0.027181936,0.018566798,-0.06290964,0.004392467,-0.0050106086,-0.0028813991,-0.0016404571,-0.047239937,-0.039156348,0.019004902,-0.02812124,0.037250765,0.04289055,0.017384347,-0.02312922,-0.03413572,0.036063787,-0.013575855,-0.041271836,-0.023290152,-0.012263898,0.080006726,-0.012252931,-0.055835582,0.05473797,0.053026315,0.042578038,0.04396297,0.04089049,0.054230582,-0.0077260127,-0.03015614,-0.043479998,0.046526488,0.026935272,-0.024774538,0.0022824674,-0.004796095,-0.09553263,-0.015990214,0.027330125,0.05289334,-0.11475352,-0.012978735,0.03634321,0.031723585,0.03652428,-0.08564675,0.05659293,0.03753635,0.046376735,-0.013950486,0.041364178,-0.122029744,0.0037159966,-0.033448856,-0.030223016,-0.009841654,-0.009794751,-0.081712425,-0.0049825213,0.08922144,-0.04064108,-0.01586692,-0.008676057,-0.056778207,0.08657621,0.07895936,0.11762012,-0.024009632,0.009153616,-0.012617794,-0.045239683,-0.039576877,-0.031014426,0.09391829,0.014818818,-0.021295663,0.04358876,0.0035516114,-0.0066979975,0.017827118,0.16355747,0.050412215,-0.0050782864,-0.019854443,0.015992474,0.02467769,-0.050556585,0.0011196535,-0.039565515,0.0044877054,0.058201246,0.05931045,-0.02755762,0.08683082,-0.07812124,0.080831036,0.006912417,-0.0576792,0.0019436223,0.16434458,-0.0009021486,-0.026990421,0.0063824793,0.035155527,0.011412747,-0.054088123,0.021243611,-0.00946119,-0.018312741,0.05416466,-0.036716104,5.6196895e-33,0.05498389,0.07814223,0.018405188,0.004307919,0.0019304558,-0.06027498,-0.062922895,-0.016737146,-0.02793416,-0.03927443,-0.068607844,0.056707684,0.08863672,-0.09286997,-0.060478635,-0.026982227,-0.05237448,-0.007954013,0.06189353,-0.0041716117,0.036749385,0.021444336,-0.0095299035,0.098543584,-0.003462525,0.027611332,-0.0785946,0.0492101,0.00997221,0.0013714635,-0.02173983,-0.06372915,-0.09238453,-0.038264107,0.017807145,-0.08565793,-0.11667346,-0.046441786,-0.012309272,0.065806486,-0.04226722,-0.02700555,-0.031900924,-0.010632436,0.03572623,-0.10070965,0.02749367,0.03754562,-0.02729556,0.07513256,-0.018756468,0.011686146,0.054657705,-0.0017834716,-0.09305574,-0.062006474,0.023497704,-0.09981912,-0.00217371,-0.012114394,0.03610955,0.024102218,0.0012063253,-0.023947677,-0.026779903,-0.0036996398,-0.07830504,-0.07267664,0.055924308,0.03183871,0.034934957,-0.013340787,0.03934659,0.03907368,0.06976374,0.04442343,0.009571237,0.018942306,-0.03519547,-0.015664732,-0.012977893,0.079398684,0.10263351,-0.04451805,0.027119884,-0.0053734137,-0.06864582,-0.077429,0.019426314,-0.021638814,0.0036366563,-0.026908759,-0.0099542765,-0.097247414,0.049464446,-6.625656e-33,0.10175308,-0.08101892,-0.010337528,-0.08299658,-0.070588306,0.1020503,0.0049129785,-0.094134174,0.08479175,-0.059450805,0.06579491,0.047311973,-0.0059347954,-0.07675218,0.060064524,-0.05396295,-0.06590085,0.0831107,0.004823282,-0.037038706,0.072858684,0.01288736,0.008495893,0.00031683836,0.012403977,-0.021591736,-0.043755356,-0.07594268,0.049136326,0.095800266,-0.05651011,0.006731281,-0.049168892,0.07532668,0.05311454,-0.002871017,-0.029262561,0.045745783,-0.08397099,0.028266191,0.0019597537,0.021539057,0.057493635,0.0125060445,0.051833753,0.061953362,-0.101428255,0.01103241,-0.0010313689,0.04347818,-0.007907078,0.060895443,-0.12469035,0.051864892,0.08427312,0.09738026,0.077106856,0.0062865005,0.039929062,-0.031262387,-0.07127643,-0.088480294,-0.015772505,-0.06053559,0.0845204,0.024083985,-0.01313175,0.04069452,0.058493245,0.008840183,-0.010629312,0.058783256,0.011281208,-0.025934273,-0.0007366347,-0.015258988,0.04060611,-0.048222605,-0.065000705,-0.030682217,-0.02372243,-0.00067736936,0.050408546,-0.07312109,0.0054265405,0.016305191,0.042783577,0.0048304643,-0.100827836,0.015250236,0.030316684,-0.052645817,0.010746238,-0.024320174,-0.016298132,-4.8666088e-08,-0.021472229,0.037121326,0.0020790834,-0.024676243,0.073402524,0.109661505,-0.100925356,-0.025128769,0.031439997,-0.0572778,0.008399169,0.06162696,0.086764306,0.02858415,0.024118911,0.016974488,-0.07966554,-0.019514868,-0.008639467,-0.04576846,-0.09680901,-0.044929713,-0.08243636,0.053350363,0.072583646,-0.0066790124,0.06777077,0.017270137,-0.009803283,0.0070376764,0.0060533225,-0.014348077,0.0004911688,-0.028962215,-0.021993546,-0.04156919,0.024730923,0.07650924,-0.08541396,0.046830013,-0.03151979,-0.072768696,-0.04157715,0.06393809,0.075167745,0.0793855,0.017309811,0.055618312,-0.04454725,0.0448273,0.00510527,-0.0405614,-0.035306975,0.018642232,-0.060134593,-0.02162456,0.0011521648,-0.044828843,0.009528703,-0.08072162,0.0033197836,-0.0009783757,0.0802775,-0.04085149 +2.5.1.18,"A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.",384,1.0,-0.0017171141,-0.048077364,-0.06419358,-0.012420974,0.054338742,0.009606054,0.026788244,0.0041977665,0.026668139,-0.06275273,0.020134103,0.01926442,-0.04323029,0.07234264,-0.040257405,-0.008922299,-0.059759095,0.014868152,-0.090220384,-0.06895157,0.054162554,-0.002541222,-0.038958494,0.014350438,0.026963664,0.04811035,-0.009521837,-0.09231081,0.03471189,-0.001631439,0.006470793,-0.003772668,0.07214062,-0.03970689,-0.012775034,0.10301382,-0.059894174,-0.013258553,0.0072957757,-0.019672755,-0.021307467,0.010633491,0.01562221,-0.040779304,-0.007871351,-0.030785639,-0.005017868,-0.001298106,-0.049530383,-0.0022575096,-0.012291403,-0.073152594,-0.104462236,0.06666589,0.10130053,-0.048088744,-0.09372884,-0.111419246,-0.11271937,-0.048930928,0.102281965,-0.0022938913,0.039396044,0.01372167,-0.036421593,0.0425045,0.020577254,0.011102252,0.015106969,-0.04699164,-0.060211517,-0.048563696,-0.08099778,0.010581687,0.015098712,-0.022407321,0.034277607,-0.026280252,0.00826309,-0.0426995,0.021643246,0.07458473,-0.0035139942,0.09438854,0.05076686,0.041652486,0.049646426,0.0019979458,0.010228433,0.048766896,0.0018831631,0.046817698,0.054258537,-0.066793256,-0.017891992,-0.0038034439,0.011667185,0.031263255,0.032620423,0.02033003,0.040373806,0.012509722,-0.05623864,-0.06914448,-0.17992409,-0.015864633,-0.04652953,0.06037976,-0.0006575948,-0.023033425,-0.08865912,-0.029961029,-0.019171871,-0.026880745,-0.06474491,0.045891456,0.08448651,-0.00025246802,-0.06538802,-0.0022376757,0.0056248126,0.03588892,0.036502443,0.022843422,0.03829306,0.03322572,-0.11865044,6.1218328e-33,0.026623638,0.09362341,-0.0033849787,-0.03961378,0.017556258,0.032341346,-0.032066762,0.05652443,-0.036939688,0.0127447415,-0.051263314,-0.005283411,0.00088411523,-0.048782635,0.069580264,0.026898358,-0.025853895,0.08597045,0.023164457,0.013500658,-0.037217394,0.061469458,-0.087730244,0.047537174,-0.017642107,0.029003996,-0.024629332,-0.06672353,0.009399524,-0.0366152,0.036266938,-0.0377303,-0.072315425,0.09039899,-0.009945374,0.014207181,-0.03473871,-0.02821132,0.0011219224,0.023556972,-0.046145618,0.023697032,-0.043242767,-0.031605996,0.09176536,-0.050325252,-0.08011075,0.09225652,0.040018737,0.056779608,-0.028873364,0.039287128,0.10997258,-0.026413491,-0.016105844,0.063737154,-0.054878376,0.10461654,-0.012925528,0.014333302,-0.002144943,0.076899365,-0.08333161,-0.023830121,-0.027449062,0.009877344,-0.028708313,-0.042130142,0.092866935,0.14261676,-0.050822612,-0.056425083,0.065174885,0.076785155,0.052897193,-0.03168538,-0.06053396,-0.014220613,0.039580304,0.043954857,-0.033539273,0.01630897,0.032776855,-0.09482672,-0.12619731,-0.027756782,-0.015034246,-0.01975613,-0.0012778359,0.019358499,-0.04355619,-0.057851136,-0.066060916,0.009594456,-0.028845826,-7.680742e-33,0.08493488,-0.08400304,-0.040224265,-0.030150257,0.021752998,0.0042525507,0.020596828,-0.08225279,0.05126348,-0.010916136,0.036447342,-0.028328475,0.026214607,0.030578014,0.024607467,-0.048866063,0.017595246,0.05207254,0.005056938,0.021891944,-0.020801175,0.07132578,0.008858686,0.026661666,0.081327245,0.032923672,0.00663508,0.055500478,0.12579292,0.0447865,-0.053840574,-0.0005801824,-0.015521939,-0.045611,-0.0051664403,0.045335267,-0.0045091133,0.054722413,-0.047835946,0.01802811,-0.0069532925,0.038584877,0.11117846,0.12557508,-0.012315153,0.048966713,-0.09574433,0.059010975,0.011089998,-0.050816797,-0.019412,0.023632506,-0.018227777,0.016977474,0.040433757,0.088953294,-0.05325279,-0.052715827,-0.056267936,0.00013545711,-0.045913387,-0.11929896,0.02395142,0.027012667,-0.051550873,-0.07353542,-0.03159603,-0.058889054,0.031416256,-0.039406475,0.067472346,-0.07224587,0.02146931,-0.00521217,-0.06776986,-0.07281479,-0.04480802,-0.08244861,-0.015134293,-0.049696364,0.07550131,0.0029692617,0.022533812,0.006991091,-0.020021575,-0.04857211,0.006139785,0.17149703,0.047856946,-0.023648608,0.007417006,0.020770678,-0.045839746,0.056110162,0.026184695,-4.9286545e-08,0.06529978,-0.08279663,0.048505783,-0.025670914,0.014386109,0.021864459,-0.0015021339,-0.044444643,0.015813688,0.0478717,0.040762674,0.039174583,-0.07764567,-0.014837442,0.0384561,-0.024521314,-0.03141916,0.012649852,-0.011170233,-0.012011396,-0.055403035,-0.025958039,-0.11725191,-0.024344314,0.0013342035,-0.08180088,0.03863686,-0.0022700727,-0.03799804,-0.009224887,-0.015569317,0.05806728,0.08902063,0.023986097,-0.039426014,0.03925906,0.022281172,0.024353696,0.012457346,-0.047588814,-0.0233553,-0.018818403,-0.052112207,0.049526725,0.01179567,-0.027078662,0.0064790947,-0.014708646,-0.013537386,-0.001171933,0.025967125,-0.016096154,-0.03583562,-0.048103034,-0.06609262,0.09905019,-0.017155083,-0.051838852,-0.0011697002,-0.04957481,0.022258505,0.008853973,0.19083762,-0.03318077 +2.5.1.20,Rubber particles act as acceptor.,384,1.0,-0.004695093,-0.056318905,0.061371315,0.041425552,0.08419136,-0.057036556,0.114755996,0.06390434,0.022225078,0.034369018,0.091764964,0.046398956,0.01424812,0.04866116,-0.0011547153,0.003404881,0.0021091632,0.028710483,-0.03139588,0.03459408,0.037099283,0.025417328,0.017537145,-0.029921593,-0.08292728,0.048072234,0.047092885,-0.029253341,0.0031232939,-0.08411645,-0.020640584,0.006050027,-0.06435856,0.018763682,0.03322258,-0.019025605,-0.021434732,0.04393751,0.021849882,-0.026367614,-0.004578906,-0.06534326,0.04577372,-0.031844083,-0.006530647,-0.04379286,0.07452389,-0.0036974063,0.06456653,-0.021785123,0.030572357,-0.0047007147,0.021325573,0.044117317,-0.08842655,-0.010107565,-0.042536546,-0.017275225,0.0095424475,-0.074286595,0.037711807,-0.00782857,-0.025036342,0.049685758,0.029603554,-0.088310204,0.053342227,-0.024560409,-0.025406618,0.07199216,-0.0024974968,0.12318998,-0.03048232,0.01589262,0.077668205,-0.023997383,-0.06465502,0.06168621,0.05392542,0.1138667,-0.039653078,-0.008377633,-0.0011142314,0.010027912,-0.030713381,0.039502863,0.03998383,-0.0022890046,-0.05189863,0.018467683,-0.049060926,-0.006796714,0.056145452,-0.01341998,0.00063616055,-0.06041903,0.0017737603,0.038045853,0.041941572,0.06196569,-0.05843784,-0.030095391,-0.009850276,0.04578658,0.013325556,-0.0031202452,-0.046777744,-0.07024629,0.08956032,0.044128228,-0.008175935,-0.09415644,0.026839575,0.0643291,-0.103764355,-0.012103152,0.008343444,0.011011823,-0.031849813,-0.06447898,0.011719853,-0.008439684,-0.052539606,-0.03981627,-0.0125333425,0.0019744795,-0.02208654,-2.1997764e-33,-0.041528326,-0.027385866,0.06624921,-0.076676995,-0.06267744,-0.08021372,-0.026505118,-0.014227217,0.037300702,-0.017925007,-0.08951062,-0.0066131386,-0.024153681,0.07091204,-0.01914123,-0.034206413,-0.00436865,0.055537328,0.004775402,-0.04026736,-0.027442226,0.029524395,-0.038258612,-0.0113444,-0.01588408,-0.0077066016,-0.047065,-0.073552,0.030727267,0.0006278432,0.098589435,0.077037714,0.02150259,0.19966179,-0.020246865,0.05458125,-0.005206365,-0.0044259373,0.009556685,-0.1219951,-0.019091794,-0.059735376,-0.027169313,0.021934373,-0.010646674,0.0051674084,0.010316519,-0.049213525,-0.005732768,-0.011081189,0.06438303,0.03690823,-0.022823693,-0.028459433,0.06477017,-0.041614138,0.009720112,-0.01780265,-0.11739844,-0.028160643,-0.0110073015,0.039517317,0.027002128,-0.009380531,-0.0109311165,0.003297227,-0.026696987,0.029551368,0.054951765,0.0132613545,-0.06503031,0.04578143,-0.08425293,0.03760771,-0.037539758,0.018297447,-0.006996954,-0.0010916662,0.056330804,-0.0144370245,-0.067106664,-0.07973551,-0.040023584,-0.05508243,-0.09512942,-0.038682356,0.022348221,-0.067839324,0.097947516,-0.0034611877,0.016655322,-0.029101763,-0.059419636,0.12173092,-0.0020698877,-4.0792567e-35,0.01401644,0.0005736667,-0.013355084,0.14050348,0.033557612,0.064697735,-0.01755319,0.020271393,0.05498154,-0.05466645,-0.017360747,0.04239259,0.00520247,0.080528274,0.035151824,0.035726257,-0.019556653,8.594116e-05,-0.014936288,-0.030480344,-0.08379345,0.049992464,0.046698373,-0.018696293,-0.056230497,0.040284645,0.04331542,-0.061483778,-0.034878634,0.033532888,0.033208366,-0.06175258,0.01807931,0.001134822,-0.03064125,-0.04807954,-0.037152503,0.028035577,-0.012795019,-0.12234651,-0.0003232264,-0.022014791,0.033650223,0.019881,-0.039034396,-0.04104627,0.110034704,-0.010905079,-0.03455332,-0.023454716,0.014034019,0.056685332,0.02466135,-0.003894339,0.05821168,0.14802681,0.026989972,-0.0729898,-0.0040039616,-0.034458492,-0.042237822,0.048185676,0.043987975,-0.03405277,0.00078829896,-0.04647943,-0.033869565,0.041431986,0.028504519,-0.055579055,0.14081183,0.019563064,0.07366967,0.034244318,0.10208457,-0.040824044,0.038518377,-0.12632999,-0.06436519,-0.0024738365,-0.14189288,0.115837574,0.023341117,-0.018357052,-0.033470858,-0.021108026,-0.008470477,-0.0511659,0.017525252,0.07219277,0.077126056,0.045227204,0.10285639,0.053426664,0.026316615,-1.6267027e-08,0.018817442,0.023542365,-0.013254786,-0.06377953,-0.050909568,0.07181788,0.06398481,0.025418935,-0.057476923,-0.06200845,-0.027865818,0.012191432,-0.0015430298,-0.009614094,0.0985579,0.023460181,-0.09223541,-0.00094921875,-0.099879794,-0.08124943,-0.089277096,-0.015833639,0.044767167,0.021110928,-0.061874066,0.01318484,0.018919751,-0.02288861,-0.012623609,0.07222034,-0.060584318,0.08956004,-0.07576066,-0.05094679,-0.02983138,0.030663233,0.051076878,-0.04829499,0.01171895,0.033039328,0.07928712,0.020996926,-0.010770338,-0.04902939,-0.03767879,0.054874077,-0.09695214,-0.0096667,-0.0742336,0.0828708,0.016648639,0.0072997403,-0.010997868,0.057669006,0.0029871457,-0.024877258,-0.034586616,-0.017764624,-0.006711214,-0.03278902,-0.055970497,-0.034675654,0.11546095,0.029558286 +2.5.1.21,"This microsomal enzyme catalyses the first committed step in the biosynthesis of sterols. The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP) [8]. High concentrations of FPP inhibit the production of squalene but not of PSPP [8].",384,1.0,-0.025693296,-0.043391593,-0.0034597572,-0.024063574,0.019489728,0.010337586,-0.0985524,0.0524451,0.037626356,0.05264489,0.009436847,0.036153637,-0.05224698,-0.0043243454,-0.034982868,0.004301892,-0.030390153,0.02360912,0.07816115,0.029192235,0.13536371,-0.0033186984,-0.010194887,-0.061808422,0.059392113,-0.02325533,0.053648673,-0.013695799,0.04112795,-0.032189596,-0.0031121569,-0.020471204,0.072398975,-0.052500762,-0.058844704,0.1263577,0.0020576073,-0.03062214,-0.010813884,0.078336835,-0.008111111,-0.05517325,-0.0270826,-0.04772583,0.038860526,-0.024084292,0.0275257,0.031059397,0.0018343085,-0.048856568,-0.043464527,-0.046990905,-0.006367603,0.00013311261,-0.036632992,0.008143614,-0.0007560798,0.0022038517,-0.010573413,-0.047689576,-0.016922282,-0.05706177,-0.05453923,-0.07072672,0.004629355,-0.033757895,0.015920425,-0.008460145,0.06935004,0.04549311,-0.10177195,0.05774613,-0.077015504,0.006095817,6.7056506e-05,0.0010844033,-0.019278508,-0.043466587,0.030010378,-0.03249455,0.063519314,-0.054335073,-0.054121777,0.03113787,0.11243851,0.055500884,0.021759113,0.061509732,0.023340598,0.03141615,-0.0014741081,0.0527061,0.02685274,0.058925945,-0.11056839,0.048734177,0.0039063883,0.07097417,-0.029745338,-0.05343659,0.11815903,-0.011413357,-0.04828563,-0.037457336,0.012597872,-0.015113952,0.019991076,0.060251143,-8.67256e-05,0.035249975,-0.020275006,0.0097862305,0.06562125,0.022037635,-0.07914215,0.10949069,0.0058104102,-0.076359764,-0.08866626,-0.0352226,-0.032217264,0.08729988,-0.032898523,0.11108948,-0.046466395,-0.0012395714,-0.035072736,4.8968068e-33,0.042585324,0.073060006,0.038146373,-0.029279107,-0.049387496,0.013584545,-0.061842952,0.020945113,-0.008661449,-0.03754717,-0.019573377,-0.10835541,-0.019828904,0.015875125,-0.036835987,-0.07995611,0.09025618,0.042653188,0.14927514,-0.067066774,-0.081697926,-0.0136199035,-0.07483888,-0.0034243537,0.053895082,-0.01590206,-0.023396078,0.01212331,0.01688736,-0.029999886,0.03568978,-0.121074334,0.009666285,-0.018562028,0.04534285,-0.050700705,-0.008157911,-0.07973533,-0.066777065,-0.015785502,-0.0345595,0.01898609,-0.048764296,0.031556558,0.042221725,-0.07403991,-0.061845712,0.053125463,0.085092925,0.07550921,-0.009738407,0.028798513,0.0556765,0.04053567,-0.072142564,0.029709376,-0.061622545,-0.024203174,0.018220196,0.049541917,-0.017882403,0.060201373,-0.030464182,0.08490413,-0.06327385,0.01625484,-0.038237493,-0.02975405,-0.013186196,0.08879524,-0.069287,-0.027683469,-0.012934443,0.00017065686,0.03404466,0.04157305,-0.034720227,0.05308156,0.009945571,-0.009829669,-0.0017451829,-0.06529857,-0.09791726,-0.045780186,-0.08426283,0.03873565,0.021357222,-0.077344574,0.06946422,0.031815894,0.056862712,-0.12942256,-0.0346795,0.050141495,0.013234013,-5.021719e-33,0.080755845,-0.011657798,0.025527362,-0.08044329,-0.023488928,0.059335213,0.03927626,-0.13901159,-0.03769845,-0.03979653,0.027112758,-0.09226273,0.030907342,-0.09228414,-0.017875362,0.023379127,0.060370665,-0.0024689804,0.032431543,-0.0029466886,-0.04568077,0.08797181,0.055352066,0.11392598,-0.049899273,-0.013669794,0.06793306,0.03163347,-0.008048302,0.09561827,0.086216144,0.005028715,-0.05877067,-0.03575947,-0.021594312,-0.010967801,-0.02711704,0.026539246,0.04027331,0.03869396,0.032974042,-0.010952523,-0.03099919,0.012662107,0.014529821,0.031188793,-0.0028225724,-0.017261565,0.045236096,-0.1190319,0.0035352975,0.06741096,0.017647395,0.028810004,0.0721479,-0.027648922,-0.035270512,0.025802828,0.08473544,-0.057728227,0.006314273,-0.03353327,-0.004847497,-0.07906997,0.04530647,0.03415459,-0.015416934,0.088005185,0.03276986,0.007969646,0.041958347,0.073759966,0.060773816,0.06112212,-0.07418767,0.051219344,0.008298743,-0.05310129,-0.051054228,-0.045508,0.0269711,0.033559486,0.0089624645,-0.103564546,-0.082404256,-0.042094134,0.01655872,0.03612477,-0.029154414,0.023399988,-0.046722643,-0.020724185,-0.037601657,0.042014148,0.03571195,-3.969701e-08,0.0049911677,-0.031553846,0.046569277,-0.03964829,-0.09464253,-0.009829251,0.07058168,-0.017799558,0.017871918,0.017374098,-0.09153805,0.05908519,0.07228074,-0.012634037,0.08023226,-0.021371242,-0.087679334,0.028431235,-0.0022563047,-0.08299918,0.026096683,-0.022303246,-0.1231179,0.06954151,0.030738467,-0.041550104,0.04078181,0.031139463,0.039384667,-0.032088626,0.09282452,0.015346186,0.014991333,0.02581482,-0.014114934,0.039833717,-0.05867628,0.045574322,-0.038901582,0.06526775,-0.03329902,-0.019961754,-0.02180637,0.035231788,-0.051192917,0.013007325,0.08145601,0.023537109,0.04484231,-0.003643648,0.03804711,0.011552984,-0.033912193,0.0032351501,-0.026821187,-0.032315407,-0.04067447,-0.03691434,-0.0296927,-0.046606902,0.03877709,-0.02211024,0.13204773,-0.010690214 +2.5.1.22,"The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).",384,0.99999994,-0.0046017305,-0.030514129,-0.083505996,-0.056038957,0.028549671,0.011040887,-0.109429725,0.002258713,-0.002023211,0.07967019,0.06397747,-0.07480492,-0.096071064,0.10597197,0.039261937,-0.0027051298,-0.006712213,-0.022592112,0.05127618,-0.002481713,0.09093782,0.060650088,0.0033371428,-0.020142429,-0.01619255,-0.030528707,-0.024899734,0.02658919,-0.04211886,-0.079648726,-0.04259658,0.029675372,0.05092903,-0.090263985,0.055536464,-0.04716592,-0.05490297,-0.010538733,0.07540517,0.07566441,0.09968503,-0.025594212,0.0066911033,-0.030532183,-0.04051645,0.0025867382,0.0486792,0.037712377,0.077299386,0.0655431,-0.07154639,-0.04893256,-0.012243952,-0.0089772325,0.004491216,-0.03634803,-0.012600109,-0.04706154,-0.046550423,0.05653254,0.00586278,0.054520547,-0.0063471724,-0.03212293,0.06548397,-0.013535826,0.027902327,-0.06458552,-0.0010136294,-0.039695248,-0.052219782,-0.08298235,0.032266144,0.074097924,-0.008888971,0.05427201,-0.0153426705,0.038894136,0.04754806,-0.073310584,-0.02963136,-0.08576221,-0.0850075,-0.014070544,0.0218694,0.0186148,0.025931591,-0.0143298125,0.013206931,0.014787133,0.013346795,-0.04974366,0.026426278,-0.053301018,-0.012222169,0.053058542,-0.020801414,0.04640092,0.011837311,-0.06695951,-0.013065227,0.0121538155,-0.044094615,-0.07064716,-0.033789966,0.02066117,-0.0757466,0.064145446,0.07214061,0.010670309,-0.018195402,0.026953176,0.003006507,0.033036888,0.044929795,0.07217143,-0.03395295,-0.049013104,0.032851864,0.034654975,0.0066921655,-0.01604035,0.03216181,0.06914866,0.06932128,0.07298237,-0.038867462,-9.098099e-34,0.10615258,0.016549055,0.03971555,0.045316048,-0.0073958505,0.12136208,-0.008851167,0.026749132,-0.01736975,-0.1280275,-0.09607862,-0.047418635,0.05102412,0.0029014207,-0.034041315,-0.05487583,0.029529821,-0.08342534,0.046622038,0.030080324,0.049499772,0.07095254,-0.049385753,0.02469326,0.038101148,0.040864572,-0.029395176,-0.039269008,0.056948073,-0.019973421,0.0042569293,-0.06581965,-0.07865875,0.008420116,0.045030985,-0.0231821,-0.048285358,-0.096398555,-0.0013722912,0.023880877,0.00089295034,0.021515226,0.059004415,-0.041076876,-0.039443403,-0.0676588,-0.053812027,0.07458707,0.0860603,-0.023330411,-0.018946586,0.019631572,0.13025267,-0.04488745,-0.05416136,0.015565954,0.0118447365,0.021411583,-0.04527177,-0.014890589,0.025452493,0.032849714,-0.022965906,0.03239791,9.631266e-05,0.060118735,-0.063440286,-0.037206676,0.04652408,0.08433235,-0.038224723,0.0258992,0.041579586,-0.039782908,0.032064546,-0.017603278,-0.11595025,0.05453437,0.036148977,-0.039411165,-0.013005557,0.06267595,-0.0292787,0.053314876,-0.07093156,-0.010558135,0.038740337,0.022336211,0.06253274,-0.029957699,0.042844433,-0.099807784,-0.05493172,-0.052424714,0.055657644,-3.238846e-34,0.03768623,-0.08318434,0.060079888,0.014922126,-0.009130772,0.056708034,0.049064588,0.007002633,-0.060232915,-0.024926145,0.06879849,-0.022403894,0.11337563,-0.10994122,0.0071440763,0.010281016,-0.027340235,0.011579555,0.048796896,-0.043826185,-0.034090582,-0.014816275,0.034716327,-0.0053983405,0.117666446,-0.06490383,-0.01930861,0.0024911433,0.02320924,-0.03236833,-0.057313677,0.10268555,-0.02276089,-0.00994381,0.028591258,0.0032184245,-0.050111774,-0.0042616464,0.022645567,-0.038126428,-0.08150053,0.04221475,0.006087558,0.080190115,0.014407991,0.08831178,-0.022967469,0.048893448,-0.010798359,0.060419034,-0.047401384,-0.0297308,-0.017159125,-0.054458145,0.024022244,0.011198842,0.0040489407,-0.04514742,0.056202464,-4.873505e-05,-0.049801096,0.0025674123,-0.030239392,-0.0015994535,-0.025446331,0.022733437,-0.107465535,0.083936766,0.06749101,-0.004183004,0.13581078,-0.030405892,0.08180253,0.0012713388,-0.017132178,-0.036431205,-0.005898479,0.00569202,0.036887143,-0.018588414,0.026818063,-0.0064527765,-0.030610424,0.10241907,-0.024951858,0.032596327,0.099636585,0.094887994,-0.011777469,0.061964322,-0.048387032,-0.048184805,-0.049732227,0.068231516,0.084667794,-3.543227e-08,0.041204397,-0.05235757,0.0615827,-0.041446578,0.0479102,0.058399897,-0.030155674,0.030576315,0.039675258,0.025908414,-0.009197951,-0.038282964,0.019036094,0.028928433,0.03778394,0.03256806,0.059218075,0.053933475,-0.01670794,0.068078086,-0.028147617,-0.04902329,-0.16388032,0.03235312,-0.0010837931,-0.006152997,-3.5501573e-05,-0.04485677,-0.018317603,-0.086114675,-0.044165935,-0.020738011,0.008810766,-0.07943992,-0.08559963,0.046527196,-0.024821676,-0.0320211,-0.00791198,0.015815046,0.03347545,-0.10203316,-0.05327173,0.003590084,0.07069368,-0.029378684,0.0058396347,-0.037040815,-0.04359754,-0.025973352,-0.10304536,0.031901643,0.021262672,-0.06631239,-0.03995801,-0.0023919959,-0.04310987,-0.09011521,0.002371697,-0.018056849,0.05785857,0.052576367,0.1573964,0.009818019 +2.5.1.23,"The enzyme has been originally characterized from the protist Euglena gracilis [1,2]. The enzyme from the archaeon Sulfolobus solfataricus can transfer the propylamine moiety from S-adenosyl 3-(methylsulfanyl)propylamine to putrescine, sym-norspermidine and spermidine with lower efficiency [3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.22 (spermine synthase).",384,1.0,-0.028876008,-0.029338127,-0.12396972,-0.100813225,-0.026077706,0.049907967,-0.061858382,0.0148046,-0.010649477,0.07361691,0.050925907,-0.030456051,-0.05013026,0.05632984,0.028062703,0.019462233,-0.016442,-0.048207153,0.038056392,0.018258382,0.10762903,-0.020718483,-0.08279418,0.006446762,0.019363163,-0.00020802915,0.02114756,-0.014163953,-0.037981484,-0.039515365,-0.019572387,-0.07956975,0.03803332,-0.046813417,0.054647237,-0.0036101772,-0.08984058,-0.027602123,0.037304334,0.05474979,0.07669562,0.016171316,-0.041746814,-0.01834649,-0.083055586,0.030945525,0.122496046,0.021693282,0.040440798,0.035161346,-0.054016024,-0.110746,-0.0037733,-0.045072734,0.061953545,-0.027416393,-0.00016153393,-0.04923342,-0.004118315,0.02259556,0.014756831,0.039768413,0.0071365507,-0.09921006,0.046637774,-0.04802729,0.018947517,-0.04093733,0.028167838,-0.051882472,-0.039320804,-0.055557467,0.039921153,0.096879795,-0.04124118,-0.010281042,-0.02721197,-0.01536723,0.06673724,-0.037857868,-0.023543188,-0.08998122,-0.12065873,0.026730282,0.0054369206,0.010662223,0.058581542,0.060841214,0.08090918,-0.046683583,0.039577235,-0.055351295,-0.009646364,-0.03963339,-0.03748107,0.015545723,-0.041481826,0.030546771,-0.016979592,-0.03381632,0.035004694,0.057990566,-0.037811685,-0.12749085,-0.06906021,-0.007785542,-0.014407022,0.112405814,0.013112978,0.066471905,-0.01784761,-0.001318593,0.03269306,0.06309552,-0.025435565,0.10755808,-0.04016866,-0.048357423,-0.00328649,0.01642385,0.010225107,0.025084438,0.069928005,0.11322307,0.018131556,0.05779791,-0.07827986,2.6819377e-33,0.05279595,0.039018188,0.027644437,0.060167484,0.012462066,0.04388409,-0.026823407,-0.00013763705,0.027466878,-0.13409978,-0.10552353,-0.0151245985,0.038601615,0.014880871,-0.06385943,-0.029660821,-0.00407545,-0.022453956,0.004724825,0.0471302,0.020215344,0.04867433,-0.03508438,-0.03416774,0.024593027,0.008160806,-0.01192404,0.03336768,0.11442221,-0.017795613,0.046291582,-0.11904587,-0.09154196,0.04237626,0.09119464,0.0009421626,-0.025112517,-0.08446732,-0.00037932448,0.037335586,0.0028233428,-0.008066822,0.040210232,-0.014174904,0.017325548,-0.076147676,-0.0385921,0.1114993,0.025178658,-0.036749214,0.04085442,-0.011453572,0.07319012,-0.033432838,-0.122537114,0.045283563,-0.00012969696,-0.036961872,0.03938618,-0.005176925,0.02333903,0.0052882726,0.0036344118,-0.0035207968,0.05971097,0.05543448,-0.09897012,-0.007109485,0.02810283,0.060680192,-0.04826379,-0.007018632,0.034982014,-0.021554016,-0.042474452,-0.037287757,-0.07028962,0.026413973,-0.056604497,-0.018133352,-0.003728727,0.03853118,-0.07040271,0.039335113,-0.040358994,-0.0028227675,0.019386167,0.016858732,0.033097595,0.03058702,0.05340799,-0.09034082,-0.06294814,-0.03288596,0.021425895,-2.9217454e-33,0.061426908,-0.14236973,0.03899486,-0.019062078,0.028237605,0.05629051,0.09688175,-0.011517322,-0.034189146,-0.026566396,0.031285245,-0.0011324235,0.10179656,-0.09665035,-0.034700125,0.03367411,0.023489019,0.033065774,0.018484857,-0.087044664,-0.027501121,0.066908956,0.036887076,-0.008526645,-0.0060522207,-0.061990883,0.039654274,0.05572935,-0.018757747,0.04497179,0.01042774,0.0041422467,-0.041115906,-0.037436463,-0.033093665,0.041918613,-0.041298673,-0.009926689,0.03460099,-0.019613922,-0.06930378,0.018364664,0.00045956435,0.074663736,0.023331385,0.08427922,-0.026251853,0.01909108,-0.0077348677,0.040818457,0.045779705,-0.06350893,-0.011785991,-0.06332433,0.036425572,-0.017637966,-0.015976181,-0.020742629,-0.002729025,-0.012678662,-0.07871354,-0.014147653,-0.0072234855,-0.012491038,-0.017466038,0.03970193,-0.09751359,0.07250995,0.070116125,0.008932917,0.09912302,-0.010516552,0.054317206,0.039710123,0.0065120077,0.0032884765,-0.02422181,0.049926788,0.03039445,-0.07098471,0.00071028614,-0.036852866,-0.001015585,0.028472364,-0.0040778713,0.018515723,0.08852859,0.12916027,-0.01450282,0.043022007,-0.05531702,-0.020612897,-0.0052468716,0.083284184,0.0733709,-4.327628e-08,0.0037241573,-0.005814121,0.06800591,-0.006969185,-0.038986657,0.06345201,-0.0038685128,-0.0025265673,0.052792903,-0.044247262,-0.042367335,-0.0011579596,0.0046505854,0.04075171,0.02323689,0.04709656,0.04655685,0.089233294,-0.03452319,-0.0041750963,-0.026619468,0.0029793635,-0.11610141,0.06945622,0.0043585743,0.06917438,0.021559542,-0.03048192,-0.042315822,-0.051897597,-0.0037897688,-0.025102695,-0.044430953,-0.07788955,-0.064111985,0.073210716,-0.031368047,0.04505085,0.03371525,0.044202384,0.082200095,-0.06368063,-0.061468888,0.010293272,0.021043703,0.015662609,-0.00040694416,0.03310199,-0.06098531,0.027437666,0.0011533622,0.051249947,-0.008585163,-0.06126519,-0.059294395,-0.032528967,-0.086668424,-0.10016135,-0.034779835,0.02146258,0.09946143,0.04951434,0.1644075,0.028148934 +2.5.1.25,"3-[(3S)-3-amino-3-carboxypropyl]uridine (acp3U) is a highly conserved modification found in tRNA core region in bacteria and eukaryotes that confers thermal stability on tRNA. The enzyme from the bacterium Escherichia coli catalyses the modification of uridine47 in the V-loop of tRNAs for Arg2, Ile1, Ile2, Ile2v, Lys, Met, Phe, Val2A, and Val2B. The human homologs DTWD1 and DTWD2 are responsible for acp3U formation at positions 20 and 20a, respectively, in the D-loop of several cytoplasmic tRNAs.",384,1.0,-0.05790326,-0.08869356,-0.11839683,-0.05796511,-0.032314148,-0.0053312858,-0.04931042,-0.013262747,0.065641075,0.037986282,0.05744184,0.0053309933,-0.027188523,0.03144853,-0.043906994,-0.017152285,-0.14143343,0.04338004,0.053429347,-0.05884444,0.02350429,0.096809044,-0.048537064,-0.04433646,0.0351453,-0.02120639,0.07943171,-0.0044172257,-0.024900986,-0.058716197,-0.09279105,-0.08453196,-0.035508882,-0.04930804,0.08248709,0.02328291,-0.14517045,-0.038277116,0.06720449,0.0030645686,0.028733488,-0.012911007,0.034204654,-0.050379712,-0.010751176,0.0055989004,0.0033178872,0.019865112,0.00047068542,0.0018511328,0.03707091,0.06745203,0.019636955,0.052751232,-0.054391906,0.02808924,-0.042377707,-0.034903932,-0.02046837,-0.046131186,0.06599755,0.030482976,0.04160616,-0.08087195,0.06910817,-0.04175037,0.015645875,-0.025975613,0.018242111,0.019323355,-0.08122592,0.009029578,-0.021256305,0.039154865,0.05959805,0.034146126,0.025822649,-0.047195826,0.009810761,-0.0154696675,0.042192485,-0.01717214,0.08011518,0.044062093,0.02235387,-0.022394566,0.02308563,0.033978943,-0.03417979,0.034666613,0.014125468,0.071115814,0.045468003,0.010925986,-0.023055958,0.084676966,0.026497321,0.024583071,-0.023581855,-0.07802589,-0.0070980373,0.06948328,-0.0044815424,-0.031070642,0.023013467,-0.008471131,0.029759219,0.08229953,-0.033954922,0.0016787754,0.027992668,0.011570391,0.04399114,0.0050770645,-0.02169272,0.04558777,0.0013814046,-0.002588808,0.005574784,-0.024703652,-0.06452817,0.0257356,0.014835731,0.016291494,-0.052715175,-0.035262004,-0.06082305,2.5657609e-33,0.0011602074,0.04150805,-0.029160632,0.025112176,0.047166653,-0.046612423,-0.07928231,-0.060241014,-0.04700334,-0.0069258763,-0.10612373,-0.07451817,0.015551342,-0.048450366,-0.07231355,0.0044787535,-0.08836356,0.032637376,-0.009055922,-0.0376985,0.02960328,0.09808384,0.038346153,0.006636737,0.050512392,0.02435824,-0.014093314,0.01981042,-0.025698354,-0.01234508,0.014884523,-0.022001568,-0.13354634,0.0026478197,0.10959406,-0.010219887,0.0022129035,-0.07402038,-0.09108317,0.12892312,0.01164967,0.004935934,0.04286977,-0.022967283,0.030209932,0.018644297,0.013695437,0.07701252,-0.09977666,0.07949968,0.03244069,0.012509822,0.06318162,-0.02011465,-0.07248892,-0.06431984,-0.07076656,-0.014676565,0.085093394,0.019655759,0.010729235,0.03727102,-0.014724717,0.06643925,-0.071436144,0.062292863,-0.08128198,-0.031059,0.04794087,0.10930799,-0.04977552,-0.05840147,0.06066075,-0.0016929144,0.067586854,-0.01387343,-0.07493592,0.028755922,0.018040461,-0.030916635,-0.037941944,-0.05430114,0.02712553,-0.031125586,0.009620105,-0.08708435,-0.008516748,-0.015180019,0.028540859,0.025397012,0.069788724,0.055595268,-0.026036827,0.048650693,0.01416681,-3.4153816e-33,0.13813122,-0.12146812,0.07837401,-0.05186783,-0.055279512,0.047612835,-0.01426991,-0.06505754,-0.012851502,-0.08957844,0.11778737,0.05228927,-0.03415051,-0.09169697,0.08572675,-0.07945918,0.04948716,-0.033388067,-0.013334029,-0.0019756104,0.0107183345,-0.0019055823,-0.039972488,0.03008524,-0.058845088,0.0098149525,0.02569176,-0.0062987874,0.08515563,0.03394718,0.018707555,0.06359731,-0.04716708,0.033327606,-0.038019408,0.04383951,0.0010492149,-0.019856947,0.04258428,0.014667033,0.051350676,-0.043017335,-0.031814635,0.04035153,0.03582169,0.08942853,-0.0017685099,-0.046695624,-0.058849864,-0.095584735,0.11252236,-0.061942905,0.0530848,-0.057882354,0.04499252,0.08893047,-0.00323699,-0.0061930497,0.06278801,0.056502253,0.0047980864,-0.019901643,0.07135401,0.022054533,0.010179327,-0.016927391,-0.028281098,0.049623176,0.029188802,-0.0029786306,-0.0054859356,-0.02102718,0.0035726181,-0.009116506,0.0020677403,-0.04412527,-0.05360535,-0.011758298,0.10711095,-0.052997738,-0.0979938,0.00068836514,-0.018708296,0.009601114,0.024713362,-0.046868786,-0.0033230847,0.13961984,-0.012647307,0.02808333,0.011630512,-0.0035048805,-0.0073200194,0.06378813,0.013595553,-4.4630582e-08,0.035202663,0.042852487,0.04560089,0.016828552,-0.025731098,0.078366905,-0.020627825,0.08288001,0.08906448,-0.002899108,0.009905855,0.0084918,0.029965296,0.026123604,0.053188376,0.045076754,-0.13956152,-0.017100709,0.0092783505,-0.05304158,-0.12117579,0.03341591,-0.12860768,0.030161096,0.057105355,0.04223507,0.017594652,0.030117733,-0.032933395,-0.059198268,0.021674298,-0.037957128,0.018051276,-0.0020614779,-0.020964794,0.0030837979,0.010983506,-0.07816515,-0.012896317,-0.0068023275,0.017313337,0.051667936,-0.07082261,-0.02547175,-0.07648765,0.0041053086,-0.00037290677,0.06506748,-0.13770056,-0.03312244,0.015607255,-0.0037878281,-0.01120294,-1.19297865e-05,-0.043712012,0.008080129,0.0038200656,-0.11160855,-0.01638499,0.04493879,-0.020883774,0.0011236161,0.02409861,-0.013185309 +2.5.1.26,The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage.,384,0.99999994,0.017720187,-0.013957419,0.00733038,0.031747747,0.07054931,0.03456641,-0.045943446,0.016168179,0.027338179,-0.11978821,0.11567592,-0.06565873,-0.11958862,-0.0002559977,0.038696777,-0.024571344,-0.04210151,-0.038739245,0.025688171,-0.0029865934,0.066964455,0.026672387,-0.015900688,0.032931622,-0.0021410645,-0.019159457,0.048440136,0.016330458,0.04230498,-0.116958715,0.034167517,0.023604214,0.009512412,-0.06461465,-0.039739612,0.00031965153,-0.023867879,-0.054959007,0.05408851,0.0059106243,0.103679016,-0.0941261,-0.010039133,-0.030911196,-0.045623053,0.015302386,0.001090173,-0.008151073,-0.0037582216,0.01707821,-0.009466224,-0.049544137,-0.019383714,0.0147705,0.065929614,0.009580873,-0.02289812,0.04798631,-0.056116253,0.07637542,0.056162138,0.077053756,-0.011370296,0.059214175,-0.0637097,-0.065866545,0.019565817,-0.030636089,0.008665136,-0.011196766,-0.07574217,-0.10757887,-0.036766004,0.014613009,0.038420916,0.014752336,-0.007168536,-0.033315778,0.023810241,-0.015021007,-0.03617857,0.03538098,-0.023306375,0.05256692,0.081761755,-0.0035145287,0.009906409,-0.08482082,-0.050977804,0.011051255,0.0050516995,-0.035306383,-0.06211988,-0.007832181,0.034565106,0.047601394,-0.03509504,0.013545225,0.015277764,0.02141707,-0.0071134856,0.08171611,-0.019290103,-0.0924452,-0.09140735,-0.025756015,-0.019061977,0.08337179,0.0021606586,-0.01227962,-0.012721847,-0.015277843,0.051994503,-0.014850679,-0.038807586,0.016104307,-0.0112108,-0.036623113,0.032013126,-0.037097525,-0.0161985,0.0035710756,0.0404521,0.05993783,-0.08490884,-0.014125357,0.0067749247,-3.063518e-33,-0.0066749044,-0.033806764,-0.040345665,-0.047881458,0.004049278,-0.08945518,-0.057532907,0.0051499954,-0.07463546,-0.06108962,-0.0021809372,-0.011020195,-0.05857063,0.122446865,0.046434723,-0.12357123,0.021045273,0.10593956,0.06348375,-0.04056792,-0.06412881,0.077444576,-0.01733854,-0.04029376,0.053250406,0.05034416,0.010522611,-0.031319987,0.011067482,0.00441753,-0.01695635,0.03578637,-0.05429409,-0.0070348014,-0.021808876,0.019115003,0.022226613,-0.019463498,-0.06711638,0.015631933,0.08586096,0.034357473,0.06886939,0.00042610196,-0.028936617,0.021837967,-0.03022485,0.06955394,0.028734434,-0.034636352,0.039946273,-0.0811924,0.057546362,0.026881682,-0.0014358164,0.03178914,-0.09733261,-0.011895465,-0.07842361,-0.012869238,-0.010165479,0.13632505,-0.071626104,0.07853696,0.011029916,0.029805373,-0.028300589,-0.03301236,-0.06901614,-0.023376402,0.0024760729,0.03501938,0.052548315,0.07075591,-0.03791237,-0.05527865,-0.15046947,-0.011988683,0.0543285,0.02686277,-0.0036911,0.026255086,-0.013239828,-0.03352688,-0.057408758,-0.029187446,-0.041648436,-0.027794471,0.07726809,0.052529164,-0.0272749,-0.06425728,0.044299453,0.0636733,0.030609697,-3.0671706e-34,0.08659444,-0.09327684,0.072939344,-0.04788591,-0.035179127,0.017998377,0.06833181,-0.010899439,-0.02478027,-0.018185169,0.012645027,-0.018713342,0.0129264025,-0.07266032,7.835369e-06,0.03441971,-0.03912536,0.05147359,-0.030772027,-0.050009914,0.060192548,0.029007452,0.06639622,0.101821944,0.044414468,0.021050433,0.07756472,0.06610695,-0.017130343,-0.015902286,-0.018672552,-0.081989996,0.014493989,-0.029305186,-0.030563468,0.12566403,-0.02333197,0.023241531,-0.035571687,-0.07116872,0.037250068,-0.010151612,0.011302999,-0.056503784,0.059156165,-0.006017784,-0.0791764,-0.079328336,0.018034564,-0.06291429,0.03920149,-0.0064506307,0.014132339,-0.00061939907,-0.045264117,0.11576755,-0.03313873,0.03242424,0.0024771572,-0.08356591,-0.04977912,-0.008043468,0.032248624,-0.019321496,0.026611486,-0.0058332174,-0.022855947,-0.06983665,-0.040598463,-0.013253411,0.09325425,0.029997874,-0.036845487,0.058708385,-0.0113351885,-0.057656754,-0.059979614,-0.060490534,-0.042231753,-0.009273808,0.033309143,-0.027189689,-0.031260837,-0.055113133,-0.01898004,-0.046633083,0.03647913,0.032603957,-0.022955097,0.031286754,0.03459399,-0.0035808678,-0.051009078,0.07058489,0.014624061,-2.9180713e-08,0.022152454,-0.049956374,0.050100397,0.009254664,-0.0397596,0.05225162,0.04967098,-0.025035309,0.028162304,-0.072476834,-0.048867933,0.09676703,0.017218774,0.065619156,0.030145712,-0.012214972,-0.090745114,-0.0032028675,-0.0010954647,-0.054376125,-0.0643438,-0.008542837,-0.008790299,0.015148922,-0.024294225,-0.051823337,0.0324766,0.123122044,0.008084066,0.029651005,-0.0034655374,0.07467351,-0.019143501,0.07969658,0.05629798,0.0194718,0.0026019325,-0.031201977,-0.07431069,0.18408926,0.03390191,-0.046153564,-0.043737244,-0.027939858,0.079013996,0.007993292,-0.053353757,0.082155704,-0.038595792,0.053641252,0.10575991,0.020404546,0.0024272795,-0.027961863,-0.052808337,-0.08614062,-0.03241478,-0.00040849,-0.0008160605,0.015868952,0.052247595,0.022427524,0.21778832,0.05016481 +2.5.1.27,"Involved in the biosynthesis of cytokinins in plants. Some isoforms from the plant Arabidopsis thaliana are specific for AMP while others also have the activity of EC 2.5.1.112, adenylate dimethylallyltransferase (ADP/ATP-dependent).",384,0.99999994,-0.11105483,-0.02269319,-0.01940343,-0.0184429,-0.038135655,0.072738335,-0.034561764,0.001069098,0.09974523,0.031436816,0.09821495,-0.09471788,-0.037548944,-0.057593044,0.0015006888,0.04381522,-0.042649973,0.12321228,-0.05567121,-0.07073395,0.07687442,0.07675722,0.012928228,0.0017413907,0.056555793,0.0057666623,-0.06660161,0.06575061,0.015263465,-0.07035451,-0.042181425,-0.0014353617,0.058268722,-0.028008573,0.008141489,0.09949437,-0.020901237,-0.058932632,0.1025333,-0.0014122315,0.11895673,-0.016858833,-0.018972129,-0.01666646,-0.021514606,-0.035108864,0.024587382,-0.012909025,-0.03428601,-0.03612432,0.0456786,-0.041423086,0.056359414,-0.027228141,-0.015997007,-0.0015851787,-0.06098207,0.077744044,0.079356164,0.013947682,-0.0012923124,-0.015124841,0.027813138,-0.0131155085,-0.042931497,-0.04218905,0.0055141654,-0.0029154727,0.06376233,-0.029911643,-0.05470119,-0.035821274,-0.0047577806,0.009896344,-0.055596326,0.0735735,0.010751523,0.008147259,-0.06330061,-0.037504587,0.08798433,-0.00042378547,-0.016837105,0.02462238,0.032732226,-0.034926277,0.032610133,0.024467058,-0.063197166,0.027421629,-0.0010340227,0.004434068,0.090403184,-0.027006932,-0.0010150975,0.023910929,0.05123958,0.020601412,0.03557528,-0.0101510715,0.040612064,0.12375645,-0.08830811,-0.027911514,0.053393323,-0.01733697,-0.03497452,0.053916525,-0.014728101,0.008811255,0.022660362,-0.044730175,-0.068998806,-0.008726892,0.019995201,0.0768068,-0.061276443,-0.025599848,-0.03494098,-0.0005860094,-0.03770865,-0.12613937,-0.04233718,0.07595229,-0.059050426,0.03525351,-0.10687453,4.2030836e-33,0.062331863,0.020974385,0.03686267,-0.0125790285,-0.005194569,-0.05537154,-0.06418662,0.022005174,-0.016445367,-0.09443871,-0.09123164,0.01679961,0.06341564,-0.0024570727,-0.059702426,-0.055734728,-0.08863506,-0.030067505,0.09544181,-0.05272606,-0.007788256,-0.0022937881,-0.09757222,0.0016595238,-0.04363948,-0.041490138,0.0013128022,-0.02467101,0.014217214,-0.021264276,-0.019982886,-0.06499801,-0.033844624,0.030381527,0.049467273,-0.0465947,0.04320225,-0.04032492,0.017709082,-0.003061029,-0.081318416,0.026883747,0.0350269,0.0019942205,0.064911135,0.033806365,-0.015049972,0.014574967,0.08226139,0.07732172,0.020564694,-0.006185294,0.13244702,-0.05342732,0.004794008,0.0058225156,-0.039932936,-0.015607504,-0.0765453,0.10073476,-0.014650888,0.023391794,0.0015705121,-0.030149946,-0.048610553,0.12860534,-0.10182837,-0.14480393,0.00912519,0.034317166,-0.012697448,-0.028230906,0.08633162,0.0051327217,0.05148913,0.09212364,-0.01420865,0.04960536,-0.0830322,0.072524495,-0.024431372,0.014780927,-0.028142486,0.0094443895,-0.021873938,-0.043598343,-0.011672568,-0.028609503,0.044583507,0.023616076,0.05219286,-0.019599704,-0.10856091,0.027903236,0.0010780329,-4.7744885e-33,0.067892924,0.054582313,-0.01059573,-0.07240628,-0.06603788,0.0832984,-0.050567217,0.0072080577,0.017304242,0.04140814,0.028019883,0.042259436,0.0074026347,-0.02594146,-0.05155829,-0.061531562,0.0022549476,0.06170677,-0.020611947,0.06760508,-0.029075915,0.03399682,0.032446835,0.071258426,0.032846663,0.014802382,-0.00964383,0.036031958,-0.005438042,0.026955616,-0.019427497,-0.026295193,-0.058704194,-0.0068410398,-0.007593894,-0.033377483,-0.03976922,0.029882867,-0.03805709,0.0063109226,-0.0629871,0.013763089,0.032996856,0.06374927,0.03664993,0.020565089,0.059181504,0.027093539,-0.08127744,0.003949748,-0.00029645182,0.06644397,-0.046220466,0.08457175,0.029278558,0.05486904,0.051026493,0.073023856,0.012011502,-0.035385177,0.026558783,-0.08600438,0.027899932,-0.08840717,0.020689635,0.025537092,0.027257498,0.056343213,0.01254512,0.03450672,0.07289444,-0.01761403,0.0036183156,-0.035709593,-0.049675275,0.00987943,-0.05278567,-0.13362177,-0.0696534,-0.029607624,-0.009597045,0.053814624,-0.011553358,-0.07678231,-0.031832494,0.04856242,0.06816866,0.076036625,0.026561556,0.04623416,0.033031292,-0.030793076,-0.039114375,0.06775861,-0.042041976,-3.5758934e-08,0.021316692,0.027788825,0.04169923,-0.024181128,0.00827695,0.036811598,-0.008064773,0.06409576,0.03667876,0.04868487,-0.027673136,0.020280177,0.022793274,-0.025097087,0.062364284,-0.009746899,0.025160812,0.086771384,0.0056911614,-0.013676774,-0.09393579,0.009739475,-0.11531177,0.039005525,0.0111492835,-0.07793581,0.081746206,0.03145991,0.024337677,-0.009439533,0.060530256,-0.02618179,-0.010044248,-0.06876095,-0.07761925,-7.170615e-05,-0.04504211,-0.059701648,-0.05240682,-0.012882173,-0.101780705,-0.08350771,-0.017346757,0.08670886,0.004282631,0.029241232,0.04297182,0.019434793,0.020935282,-0.00033306118,0.015368306,-0.07973951,-0.017526543,-0.14827566,-0.104252376,-0.025788195,-0.05514801,-0.022609789,0.00052272284,0.053794112,-0.028771898,0.034744505,0.10534979,-0.035142362 +2.5.1.28,This enzyme will not use larger prenyl diphosphates as efficient donors.,384,1.0,-0.051484812,-0.017225543,-0.057253923,-0.07359164,0.024022069,-0.1240603,-0.053305514,0.04482682,-0.01401037,-0.02245427,0.039180174,0.012375556,-0.06567667,0.03867145,-0.04380767,0.046580262,0.032313652,-0.015144522,-0.012215609,0.029842068,0.08344632,-0.04497084,0.0054184417,-0.018102463,0.06477161,0.005165341,-0.024843762,-0.032526683,0.04260839,-0.04724121,-0.059717637,-0.016128376,-0.044215474,-0.05765464,0.055168256,0.12544365,-0.080194235,0.0034079817,-0.013566685,0.042932674,0.08139809,-0.0058502452,-0.014306406,0.020109707,-0.082392335,-0.032831155,0.006104472,-0.013827596,0.003913989,-0.028461503,-0.07869143,-0.028602112,-0.02368125,-0.038414907,-0.018005613,-0.009776981,-0.07449577,0.026697796,-0.08829784,-0.01836317,-0.04496003,0.01605822,-0.016106186,-0.018987933,0.115242794,-0.043107104,0.048242435,-0.028800143,0.015237299,0.0029708582,-0.014356295,-0.023185272,0.016756337,0.08341195,0.030295895,0.0540355,-0.05447192,0.037928253,0.037144102,-0.0028174918,-0.045891073,-0.062012374,0.01827735,0.016089423,0.035113037,0.057545986,-0.016968476,0.0018625208,-0.013309587,0.026852572,0.019745985,0.05059137,0.048413903,-0.043967925,-0.07870665,0.047458414,-0.03865171,0.028824689,-0.09032715,-0.01075149,0.06482796,0.0859046,-0.020611798,-0.049818926,-0.039433353,-0.020829335,-0.031984817,8.0948186e-05,0.04709455,0.02615831,0.038637027,0.07775112,0.12302946,0.027090497,-0.06372025,0.111903995,-0.0462886,-0.06221421,-0.072080575,0.038373332,0.014090657,-0.032743655,0.00947998,0.06129438,-0.036387853,0.052432444,-0.09353364,1.4101352e-33,0.04259644,0.014386303,0.04966541,-0.045046378,-0.07667378,0.05562554,-0.057405815,-0.0063254256,-0.029226452,-0.02566953,-0.056182127,-0.10827346,0.0925281,-0.014227897,-0.021214452,-0.011745715,0.06278934,0.012325134,0.1015685,0.01756962,0.04960642,-0.024902672,-0.068992764,0.03036968,0.03380389,0.011641472,-0.032170665,0.04561975,0.017293766,-0.008985105,0.026602333,-0.08642182,-0.021816365,-0.0056258207,0.008045286,-0.014598632,-0.0064477683,-0.063165255,-0.056642365,-0.010491462,0.025144774,0.052477222,0.05165335,0.012523862,0.06889886,-0.11599738,0.0060076113,-0.012837612,-0.08836472,0.031057708,0.056163102,-0.01603781,0.061780717,-0.00057131855,-0.019948013,0.012507326,0.05422344,0.01079343,0.018267732,0.018875714,-0.016621444,-0.008914119,-0.06571466,0.054831438,-0.045906223,0.05363476,-0.021151805,-0.05247175,-0.052920196,0.14152883,-0.010101979,-0.027845822,-0.003716846,0.046626717,-0.020121248,-0.07590195,0.023337808,0.08278753,0.099441536,-0.019535288,0.056461234,-0.059197523,-0.00096821523,-0.02016179,-0.055443447,-0.04210792,0.0032457302,-0.022700803,0.0021841393,0.014587836,0.11409551,-0.08841541,-0.057436407,-0.05969209,-0.010857858,-2.340055e-33,0.06858123,-0.06528922,0.018230142,-0.046670977,-0.046908066,0.06344843,0.104956776,-0.0377463,0.09252833,-0.061640788,0.11014727,-0.025566386,0.057644203,-0.064769804,0.042445473,0.04262387,-0.062642336,-0.0011127432,0.019180425,-0.005455345,-0.04574861,0.16500619,0.017812604,0.12467349,-0.035297163,-0.0151345655,-0.117752485,0.042963143,0.018205192,0.014807607,-0.03813081,0.0014372969,-0.083358966,-0.09168563,-0.060296923,0.00048787138,-0.041698683,-0.0013729545,0.012920234,0.015219803,0.015814452,0.008141748,-0.0012315228,0.016343756,-0.062329452,0.037323996,-0.02154414,0.00805423,0.09271002,-0.028679622,-0.032247208,0.026009332,-0.0029810574,0.014325146,0.046546686,-0.010810674,0.037773233,-0.006367178,-0.026445959,-0.0511714,-0.006194178,-0.0653745,0.008438293,-0.022412524,0.009594477,0.052955955,0.019600643,0.14297824,0.03984926,0.0060128546,0.07528868,0.016482757,0.057571277,0.011517742,-0.042621925,0.031553578,-0.019791842,0.052110367,0.060777247,-0.08238232,-0.043614525,0.07964958,-0.022398395,-0.042065512,0.09530566,-0.024773808,0.051384203,0.02506585,-0.022581926,0.08298121,-0.057614975,-0.038293898,0.09697658,0.062628515,0.09575675,-2.0996783e-08,0.05432807,-0.00089067506,0.014201729,0.0016308427,-0.022651529,0.0069044647,-0.047931112,-0.017912386,0.039383017,0.07341569,-0.05113316,0.08022973,-0.0125432005,0.03197396,0.022456128,-0.021270493,-0.03598706,-0.0258953,-0.058346163,-0.09448349,-0.12481078,0.031119166,-0.08936263,0.039106607,0.037957955,-0.016551496,0.05415801,0.018460877,-0.0072787344,-0.032498997,-0.03899896,0.023531143,-0.058795176,0.026132703,-0.058414202,0.032341,-0.005697131,0.07588006,-0.042665713,0.03249635,-0.05535079,-0.089163914,-0.086132854,0.0067009274,-0.02999278,0.012562025,0.021419972,0.023947002,0.008197555,0.048542228,0.070262104,0.007085048,-0.013120594,-0.07089883,0.001106326,0.018528538,-0.025955562,0.0076221647,0.039355855,-0.06402121,0.086965315,-0.03896515,0.11076606,-0.041456003 +2.5.1.29,Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.,384,0.99999994,-0.08048339,-0.019918976,-0.047854323,-0.09709765,0.018129034,-0.05805231,-0.025754964,0.071003415,0.0076117557,-0.036906324,0.037121125,-0.008745633,-0.07550972,0.07255249,0.023543335,0.028695974,0.020231131,0.009249835,-0.009568432,0.005444365,0.06816783,-0.049362473,-0.020487163,-0.049476534,0.070686124,-0.048332516,0.0070070717,-0.0029831466,0.08512284,-0.025588864,-0.076152526,-0.0036211507,-0.024113795,-0.05962406,0.009931337,0.12395366,-0.09571124,-0.0060979305,-0.03180233,0.05642212,0.06885776,-0.033059247,0.017213425,0.040017143,-0.10541856,-0.05115937,0.0064077787,0.0025363816,0.0035127338,-0.028214205,-0.054778624,-0.0120484745,0.008453148,-0.05502025,0.010502653,-0.027224066,-0.06529132,-0.013353293,-0.064739764,-0.008148869,-0.03931995,0.01865033,-0.036668207,-0.074599296,0.0757266,-0.04352654,0.07538043,-0.03620352,0.027547406,-0.035826698,-0.004244719,-0.008485596,0.03530478,0.055564284,-0.021844659,0.060830005,-0.038595825,0.047251467,0.033658896,-0.02613386,0.0053163525,-0.011119333,-0.011479732,-0.012851359,0.049603872,0.0847194,-0.05868094,0.043611553,0.020004451,0.026181068,0.04298355,0.032214038,0.00042445812,-0.0825086,-0.09090204,0.069031164,-0.04079993,0.04282726,-0.027074257,-0.028806433,0.08103694,0.058316927,-0.02489733,-0.05277957,-0.052493807,-0.008064731,-0.028994352,0.022872437,0.03755341,0.014914608,0.005827855,0.053146083,0.10122404,0.029855698,-0.06495409,0.09591503,-0.07895207,-0.07736359,-0.066355266,0.033166293,0.037221074,-0.060406145,0.022249162,0.058270972,-0.01048065,0.055808883,-0.10361641,4.8274537e-33,0.03261291,0.073014595,0.017031575,-0.01685866,-0.092555195,0.050539307,-0.06373242,0.010979762,-0.075213574,-0.042420093,-0.057159755,-0.097472236,0.0828633,0.04423671,-0.090296045,0.00590151,0.03442858,0.00746997,0.07869519,0.01747174,0.07929926,0.028415555,-0.016683903,0.042165406,0.03285471,-0.006116099,-0.042039644,0.05938063,0.041986287,-0.0039113173,0.06770567,-0.121216245,-0.043728884,-0.017483914,-0.00569086,-0.03175393,-0.003666189,-0.06988752,-0.06179364,-0.016697058,0.03100487,0.040551126,0.042808104,0.03241328,0.06677824,-0.079639435,-0.033564605,0.025098803,-0.047655962,0.032629814,0.05676632,-0.014071702,0.03275334,-0.045625005,-0.035484385,0.035582907,0.034623496,0.016838025,0.03932522,0.026385792,-0.041032948,-0.007837349,-0.0656191,0.001037453,0.001987307,0.03535386,-0.0050730463,-0.05643648,-0.038629662,0.14446232,-0.00073060585,-0.044894528,-0.039551664,0.10211179,0.000988981,-0.06314462,0.012966245,0.042152822,0.11389922,0.001249647,0.032623194,-0.04623935,0.008825053,-0.044558853,-0.05256846,-0.042212896,-0.0013102146,-0.08101908,-0.0036343653,0.010981317,0.07448506,-0.08430438,-0.05942961,-0.050977834,-0.0134561155,-6.324865e-33,0.10543494,-0.056480482,-0.014366507,-0.07079386,-0.036808893,0.061274696,0.10530653,-0.098291524,0.074580014,-0.037205193,0.06914044,-0.041020244,0.044349764,-0.046949364,0.04428639,0.030040234,-0.07659118,-0.004422857,0.035846103,-0.011817868,-0.06928187,0.15074843,0.06719747,0.057248786,-0.006671282,-0.034906078,-0.10662864,0.06018224,0.013850741,0.06290386,-0.04388639,-0.0211484,-0.07249886,-0.09001244,-0.061129823,0.01475755,-0.030400068,-0.0048646824,0.047984134,0.001636655,-0.02485595,-0.0034984776,0.052240632,0.028318653,-0.07096013,0.05771105,-0.0272564,0.010261453,0.09348168,-0.067877315,-0.01650094,0.04634085,-0.017671278,0.0017052984,0.041103553,0.006595232,0.005006238,-0.021089204,-0.012390742,-0.067774035,-0.05978828,-0.07440311,0.026014367,-0.044951152,0.022334974,0.069513015,0.038244274,0.08234037,0.007330082,0.005449941,0.035932474,0.02685812,0.01770725,0.03866584,-0.06291017,0.042543802,-0.040116996,0.05231284,0.047781672,-0.06487998,-0.011188673,0.047292158,-0.043094132,-0.02902326,0.06080682,-0.03557878,0.0829985,0.05994299,0.027063243,0.043014266,-0.0572106,0.012787299,0.071407184,0.06207358,0.10563586,-3.3927765e-08,0.02508564,-0.0032828182,0.023346039,-0.03485915,-0.038774908,0.0016347787,-0.051609688,0.011295115,0.022576533,0.07263582,-0.067289785,0.105511114,-0.015045932,0.03300152,0.03117188,-0.045581616,-0.045628894,-0.003671022,-0.06818551,-0.11422629,-0.04779799,0.0035565463,-0.07599125,0.0464357,0.027145408,-0.004149864,0.048520297,0.021400744,0.0063511734,-0.032351054,-0.039570097,0.020864965,-0.050349835,-0.010129734,-0.011408523,0.056846328,-0.05730336,0.024763718,-0.012677943,0.01813558,-0.0100586945,-0.092869125,-0.09110519,0.016958851,-0.008447514,0.024283191,0.009507373,0.021528557,0.014417097,0.03624781,0.049139306,-0.03669145,-0.008012535,-0.06925742,-0.014841728,0.01060562,-0.043670468,-0.01082247,0.093537845,-0.07023236,0.051480908,0.02060383,0.14183198,-0.05554007 +2.5.1.30,"This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.",384,1.0,-0.05753578,0.0052669784,-0.04815872,0.03150072,-0.0357093,0.05316678,-0.03299094,0.035427704,0.013738212,-0.015519041,0.01702187,-0.022195896,-0.06315013,-0.0014706475,-0.03632081,0.0061581642,-0.078896,-0.007974623,0.06419172,-0.064682685,0.07270488,-0.015262356,-0.060108323,-0.026208809,0.04278085,0.026384732,0.08532122,0.028372623,0.04008822,-0.08207428,-0.005850323,-0.080406964,0.022241345,-0.07239296,0.023110649,0.077171795,0.0027161445,-0.016894963,-0.008279743,0.035582803,0.069662586,-0.08482101,0.023006013,0.044770144,-0.024592383,-0.013227583,-0.022505393,0.08968772,0.0734779,0.017677642,-0.03580527,-0.039900742,-0.022647724,0.032851182,0.033601083,-0.012836142,-0.061298635,-0.011202735,-0.00043841774,-0.0077241575,0.023148526,0.020128168,-0.0050707264,-0.04137938,0.07125511,-0.042673368,-0.03391156,-0.003970261,0.06417638,0.02371639,-0.030379493,-0.02013747,-0.07993751,0.0168517,-0.029847218,0.028088646,-0.0707328,0.013711654,0.0075828442,-0.08716935,0.072079964,-0.002560061,0.043731235,0.056589194,-0.0055517657,0.02440404,0.012175504,0.015834562,0.07217534,0.030641343,0.002556916,-0.04341782,-0.0060349107,-0.05246258,-0.08161217,0.035620283,0.004680636,0.09248768,-0.018162005,-0.0034382872,0.08234175,0.041751448,-0.10337168,-0.13054138,-0.0325002,0.043538537,-0.002876596,0.043519016,0.05492971,-0.03410156,-0.055159915,0.030599726,0.03092383,-0.0465873,-0.06404908,0.031139003,0.0073869643,-0.015675094,-0.061504725,0.01468989,-0.058256615,0.08085528,0.052288517,0.10792499,-0.014132327,-0.05135175,-0.112454794,3.940476e-33,0.059248354,0.04186789,0.06228933,-2.3291643e-06,-0.095091805,-0.035641957,-0.06560304,0.03686555,-0.088713445,-0.014388417,-0.033404246,-0.050286666,0.022331754,0.00024577908,-0.0043899035,-0.056396652,0.04690192,-0.009629596,0.09237319,-0.0647478,-0.07852998,0.047023617,-0.057103623,-0.029713456,0.019668512,0.06884655,-0.025709622,0.040540133,0.024786077,-0.0074995393,-0.0065841074,-0.019512687,-0.09543253,0.013620491,0.03497935,-0.08404961,-0.09177676,-0.028298188,-0.0067994003,0.046675995,0.03604439,-0.010464613,-0.07553093,-0.019311225,0.0865593,-0.024799976,-0.026277618,0.13558331,0.097268835,-0.019423772,0.03823622,0.008843068,0.04237992,-0.02988489,-0.084484704,0.052835084,0.0137479585,0.013740595,0.06052701,0.008238306,0.015499659,0.03164547,-0.07671257,0.013786583,-0.017236141,-0.0031221844,-0.025673727,-0.027228376,-0.020006739,0.0799404,-0.03807582,-0.02884655,0.051735252,0.059494138,0.0083600525,-0.011283264,-0.06468288,-0.030523544,0.06259367,-0.038130082,-0.053848963,-0.044169765,-0.031131413,-0.0664735,-0.05581642,0.03234321,0.02461162,-0.09517847,-0.046267208,0.10515618,0.030533843,-0.061478343,-0.071797445,0.033164803,0.05820179,-6.0250125e-33,0.06932153,-0.08867916,-0.030793644,-0.10705943,-0.06658517,0.0077405805,0.04301,-0.014046133,-0.026782515,0.028294772,0.1113889,-0.027453253,0.02890716,-0.024508948,-0.040249955,0.016855583,0.042086646,0.07485101,0.074942164,-0.04993601,0.011757788,0.08630424,0.027699914,0.060363494,-0.026029155,-0.0026472718,0.085274614,0.07145614,0.039159726,0.16917436,0.024466844,-0.050917465,-0.035883475,0.012527753,-0.051428746,0.03966099,-0.06124651,0.056092374,0.07543523,-0.035314653,-0.035412144,-0.02257595,-0.021864165,-0.029410848,0.08230847,0.07897302,-0.06405764,0.023446575,-0.090167895,-0.1138749,0.06124209,0.03406009,-0.05863979,0.00020467954,-0.029895734,0.041626416,-0.047366653,-0.06284714,0.092296116,-0.033403624,-0.025595957,-0.077121586,0.036766138,-0.07368893,0.028310334,0.06335866,0.009327792,0.018038258,-0.012900359,-0.04928006,0.06316089,-0.04831975,0.023526,0.04298973,-0.013878159,0.025715252,0.035848007,-0.04251791,-0.025734711,-0.067046344,-0.052752536,-0.042474378,-0.011621331,-0.044105254,-0.05079511,-0.027353631,0.082233675,0.09523543,0.009582702,0.13891713,0.008873546,0.062560335,-0.029480938,0.017193843,0.073367715,-3.4280543e-08,0.026851112,-0.07206699,0.122206114,-0.025119841,-0.0027138002,0.01664548,-0.016986378,0.014100435,0.033028588,-0.0053512505,-0.04077831,0.015867392,0.052718356,0.03117722,0.06532711,0.021019587,0.010698914,0.043049447,-0.024512284,-0.06608987,-0.07064209,-0.0011451006,-0.024783377,-0.045212235,9.7945755e-05,-0.06701844,0.07161997,0.050916094,-0.02331815,-0.059884463,0.049537566,0.028494837,-0.017561173,-0.047455356,-0.04558444,0.11132448,-0.007062538,-0.036336944,0.05672049,-0.037156813,-0.06513309,-0.013179739,-0.0582361,0.05290821,0.0034840333,0.013204583,0.03297319,0.07015828,-0.03559692,0.0037490574,0.01941818,-0.023125215,0.035258558,-0.07350016,0.0005802811,-0.015710097,-0.054391373,-0.007019937,-0.01262266,-0.079916686,0.01650205,0.0100558195,0.092403874,-0.044299953 +2.5.1.31,"Undecaprenyl pyrophosphate synthase catalyses the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall [3]. ",384,1.0,-0.107004665,-0.03861222,-0.043683518,-0.016279412,-0.032530293,0.0119755585,-0.068261094,0.058746476,0.09649048,-0.008786156,0.005376009,-0.022324987,0.03204347,-0.010488691,-0.009073262,-0.028309558,-0.07092865,0.017904764,0.058949746,-0.037781905,0.070121825,0.009610167,-0.0019269428,-0.0101459585,0.009593007,0.063137636,0.09234106,-0.009903134,0.030371659,-0.04909938,-0.03734966,-0.031830434,0.0011911601,-0.10470607,0.1237519,0.052969664,-0.0058385907,0.04334712,0.065769255,0.003993402,0.07063085,-0.076316945,0.029683294,0.03977977,0.0054182583,-0.032323524,-0.0048374734,0.08541512,0.042929567,-0.11450879,-0.017596055,-0.014385276,-0.061540045,-0.022787314,-0.0018534458,-0.04390048,-0.049057234,-0.007933269,-0.008927416,-0.012569785,0.03156769,0.0069704084,0.027562208,-0.067614414,0.024499737,-0.06417109,0.011866991,0.021140791,0.0685554,0.03958838,-0.121412404,0.01638811,-0.04562859,0.039806258,0.03762369,0.04109703,0.007360386,0.01178486,-0.010219959,-0.055012435,0.07204076,-0.06016129,0.019116234,0.05122465,-0.031186432,-0.049067214,-0.0023537753,0.05388484,0.038021173,-0.007174025,0.0022897127,-0.0067903865,0.017288972,-0.032040678,-0.1287721,0.033194177,-0.034196027,0.017042993,0.008451622,-0.020191351,0.033789825,-0.0013513329,-0.055583525,-0.072101146,0.012392009,-0.0017601309,-0.031768683,0.030526886,0.02913012,-0.02292055,-0.018053405,-0.013563624,0.060988862,-0.0013045361,-0.058168337,0.04915639,-0.0130887255,-0.06286854,-0.027164085,0.016459256,-0.04700481,0.013082675,-0.016103478,0.107367806,-0.0957866,-0.03744394,-0.06469548,4.913844e-33,0.015584752,0.10321506,0.036072247,0.011323333,-0.078710444,-0.022686495,-0.04680338,-0.046955712,-0.07165741,0.033493947,-0.0114122825,-0.110257484,0.03037615,0.06547021,-0.017329011,-0.040153794,0.03105762,0.081997715,0.1089378,-0.053421006,-0.047714278,0.103874974,0.01899306,-0.030694805,0.10972802,0.0731972,-0.02458004,-0.014743237,0.07597296,-0.04440719,0.08151664,-0.057059642,-0.05829415,-0.019045295,0.056118496,-0.059233006,-0.053790808,-0.04193223,-0.006229929,0.01943368,-0.016791921,0.0010382127,-0.046448965,-0.022952242,0.06802997,-0.053801414,-0.100994185,0.058470085,0.03616948,-0.019023238,0.049237594,0.023090556,0.03435231,0.011289093,-0.09663906,-0.046134036,0.025081605,-0.041626256,0.055732436,0.025410198,0.054185405,0.09248746,-0.1306936,-0.02705506,-0.023187226,0.0132465,-0.039329544,0.028663978,0.011633359,0.123296626,-0.00351479,-0.0456571,0.03970135,0.02468357,-0.0144787,-0.020350317,-0.07950473,0.010199494,0.052983966,0.037543338,0.023226652,0.0006869732,-0.018534526,-0.0441328,-0.04698215,0.011201264,-0.029356865,-0.017436681,-0.026401995,0.16112825,0.0014868692,-0.09625511,-0.034809273,0.033322386,-0.025534648,-6.1908806e-33,0.12894961,-0.06555488,-0.02965128,-0.11786787,-0.049864903,0.01902756,-0.006010784,-0.040063005,0.010904137,0.0011677897,0.019891316,-1.4747163e-05,0.05881167,0.0052341707,-0.0075140805,0.0052536316,0.016809355,0.0180917,-0.027838847,-0.0096681565,-0.00649325,0.02883386,0.011034296,0.1055044,-0.04904727,0.007665982,0.048254095,0.083486065,-0.04329619,0.10997622,-0.011199016,-0.044690367,-0.056882624,-0.045331445,-0.066681705,0.020511294,-0.01709758,0.016609546,0.0076946043,-0.038595434,-0.0063837166,0.028062772,-0.019356115,0.04160711,0.019288762,0.07214614,-0.035192166,-0.010332173,-0.0026496856,-0.041565426,0.004604245,0.038725875,-0.015033303,-0.0007171635,-0.0021844276,-0.042776965,-0.06815551,0.014190739,0.078543596,-0.063015625,-0.05049542,-0.11687503,-0.0011976543,-0.08459009,0.07053917,0.13552766,-0.0023281975,0.042682063,0.027071763,-0.0023443995,0.030685907,0.10499109,-0.006569023,-0.013010292,-0.028795084,0.11800699,0.03171696,-0.060337152,0.013437154,-0.023645926,-0.033449117,-0.052296843,-0.020461889,-0.07100211,-0.009850471,-0.06211074,0.09280652,0.1298436,0.003203773,0.06883449,0.0528624,-0.04460474,0.06510279,0.03369079,0.09944946,-3.778903e-08,0.013331659,-0.036684137,0.045442645,0.020690208,-0.028875751,-0.0058594476,-0.016632104,-0.05319533,0.04273034,-0.046085488,-0.034904886,-0.009792804,0.039453432,0.0304806,0.06964951,0.06645569,-0.02992497,0.051701393,-0.010520529,-0.06978087,-0.06770995,0.048136238,-0.106652,0.04300144,0.084007554,-0.060304772,0.020052798,-0.0696077,-0.030455336,-0.0050158873,0.06835128,-0.010615584,-0.039146155,-0.0038098542,0.041923575,-0.0034138807,-0.009121475,-0.029050862,0.009409567,-0.03222038,-0.0129722785,0.053294234,-0.11536763,0.006781995,-0.031591985,0.047789287,-0.031170508,0.043241996,-0.075602986,-0.013098384,-0.0039027045,0.0073862947,0.007993532,-0.03242947,-0.06528185,0.029928371,-0.035010993,-0.0063675647,-0.031959824,-0.005293478,0.03143506,-0.006050561,0.1432038,-0.042598464 +2.5.1.32,"Requires Mn2+ for activity. The enzyme condenses two molecules of geranylgeranyl diphosphate to give prephytoene diphosphate, followed by rearrangement of the cyclopropylcarbinyl intermediate to 15-cis-phytoene.",384,0.99999994,-0.08268658,-0.03949967,-0.007488091,0.0014240738,0.084635004,0.0151391,-0.0016079848,0.036054943,0.013388479,0.023981506,0.06916106,0.012108165,0.016621344,0.01799046,0.013729353,0.08602829,-0.061006177,0.0090950355,0.0008447928,-0.03172593,0.041235425,-0.013192198,-0.042820852,-0.03482979,0.092644945,0.0041609756,0.047526963,-0.011338117,-0.014776449,0.04217841,-0.022133775,0.035409924,0.0123134395,-0.062770374,0.0045663635,0.12710515,-0.016189812,-0.0648073,0.012961148,0.022419272,0.055279568,-0.0041776462,0.026174875,0.0006857995,-0.07632816,-0.018222058,0.081615314,-0.031452823,-0.004246118,-0.011842523,-0.096796885,-0.025695559,-0.0035915063,-0.010659578,-0.054700255,0.033390757,-0.10302286,0.04899847,-0.0074180276,-0.0018988317,0.028157497,-0.042575076,-0.05553282,-0.028298007,0.032276772,-0.043184206,-0.017694006,-0.03304223,0.06598684,0.02600564,-0.03455631,0.0069775237,-0.060852993,0.04037593,-0.018393582,0.039364364,-0.0029873685,0.052656405,0.033444323,-0.06451742,-0.0137918815,0.035541333,0.08262439,0.036748197,0.08125966,0.089734204,0.022090366,0.079064615,-0.008982334,-0.013147166,0.013586814,0.016073273,-0.03207317,0.018756669,-0.096262395,0.06255358,-0.011519252,0.007975981,-0.018714799,0.03697122,0.06809354,0.042352885,-0.03890208,-0.07041033,-0.021418506,-0.038629487,0.008885024,0.024919309,-0.034704488,0.041524936,0.060019977,0.008078645,0.06811635,-0.028188622,0.022335624,0.109354615,0.022587102,-0.035501912,0.009671024,-0.005837714,0.035812765,-0.023039421,-0.015030003,0.07785509,-0.07212586,0.0841972,-0.05905389,6.969575e-33,0.07422068,0.01835659,0.06950964,0.038786657,-0.039543677,0.006091634,-0.06242372,0.007585568,0.012744312,-0.053308297,-0.047629673,-0.115692,0.052793056,0.0029801456,-0.110416755,-0.09113909,-0.014908456,-0.024666268,0.16310383,-0.026258495,-0.029018657,0.016225379,-0.069817126,0.05657021,-0.043162104,0.038315203,0.0046466524,-0.020891167,0.09692167,-0.0061908206,0.030813428,-0.14567518,-0.115847684,-0.012933622,-0.032300163,-0.035360884,-0.049061947,-0.06373397,-0.016930442,-0.0030022515,-0.046114244,0.017552748,-0.042293392,0.045632105,0.10427685,-0.06155239,-0.044351228,0.06587405,-0.025867712,0.020238392,0.0019788025,0.031002112,0.03499112,0.02130525,-0.113132186,0.024418563,0.05285238,0.009017774,0.038620092,0.039109644,-0.032073554,0.035241876,-0.009686285,0.067778155,0.063362874,0.07509999,-0.070182905,-0.06222598,-0.020985736,0.12392013,-0.04437443,-0.093603656,0.041056857,0.05530874,-0.03269678,-0.009657279,-0.089665554,-0.08643938,0.023129726,0.04253129,-0.04544857,-0.0394731,0.01529229,-0.01498541,-0.10172215,-0.036609612,-0.04270088,-0.0854443,0.032519884,0.0400599,0.020403517,-0.04919956,-0.045094907,0.036080133,-0.008551878,-6.594688e-33,0.07149977,-0.01733078,0.010402566,-0.060228582,-0.06682073,-0.012139224,0.03496214,-0.17602019,-0.03723501,-0.023703158,0.10122945,-0.073817015,0.006369769,0.022854794,-0.037718296,0.038546965,0.012369781,0.11702319,0.07601983,0.08030956,-0.03442959,0.10165621,0.04964927,0.055939756,-0.028567364,0.01387023,0.03878276,0.05012464,-0.0090681985,0.06759408,-0.013376477,-0.045038164,-0.029327458,-0.09356016,-0.018123351,8.843042e-05,-0.08100691,-0.03386514,0.049219377,0.031782657,0.0039811875,-0.030882591,0.018836295,0.08014282,-0.03741475,0.011864413,-0.090848655,0.006136037,-0.040453985,-0.057618797,-0.06985664,0.09185562,-0.050004456,-0.03399411,0.007046289,0.023990897,0.019195566,0.006367596,0.05040813,-0.032424703,-0.04922829,-0.034136586,-0.0030471773,-0.046803247,0.05390065,0.12806879,0.010777186,0.111348026,0.006487881,0.0009135708,-0.013527034,0.034220263,0.09327078,-0.007680015,-0.074597105,0.008401895,0.046693906,0.019361535,0.03685208,-0.06722708,-0.012596799,-0.019634122,-0.0419364,-0.099687316,-0.05550535,-0.011512733,0.017834263,0.095406435,0.0100301085,0.01801845,0.020238014,-0.0551643,0.0024324425,0.040401112,0.0924184,-3.7770516e-08,-0.038348004,-0.052942757,0.063448176,-0.039000437,-0.016559264,-0.004279202,-0.0059196465,-0.00096727436,0.031150842,0.007659988,-0.010389342,0.018501747,0.020137541,0.010422607,0.06993271,0.013823029,0.011673456,0.04724172,-0.05838459,-0.06283008,-0.019557443,-0.03832289,-0.09182446,0.07276946,0.023423519,-0.03803134,-0.00465763,0.06477938,0.05805515,-0.0074415714,0.012177035,0.0117481025,0.017943114,0.035476614,-0.04379216,0.08402965,-0.036055263,0.0015947449,-0.04921769,-0.04171028,-0.095222265,0.016634738,-0.07144035,0.020800771,-0.02346356,4.668707e-05,0.0043956656,0.044506278,-0.02597928,0.013404215,-0.019843271,-0.012028508,0.06045657,-0.004657438,-0.033648454,0.022195127,-0.038583323,-0.007976381,-0.113598175,-0.011320454,-0.019182337,0.026940167,0.08833242,-0.092937276 +2.5.1.33,"This enzyme will also use trans,trans-farnesyl diphosphate and all-trans-geranylgeranyl diphosphate as donors.",384,1.0,-0.06341261,-0.006806102,-0.09244899,-0.06749743,0.02730457,-0.012934397,-0.03716684,0.07892777,0.010426567,-0.054064296,0.02403653,-0.03974083,-0.09672731,0.07313034,-0.006439961,0.048258327,-0.01006468,0.048346262,0.06855354,-0.028698083,0.065593295,-0.008064799,0.014308679,-0.029618774,0.05969744,-0.018318279,0.06678795,-0.045014285,0.07044905,-0.0549524,-0.07038128,-0.05413941,-0.024036521,-0.032575868,-0.00408677,0.11118651,-0.06744513,-0.050899364,0.00237535,0.046184346,0.08261336,-0.036344014,0.021753483,0.0044956473,-0.05886065,-0.037633643,-0.0028451579,0.013351942,0.02348512,0.014456617,-0.035036527,-0.057154987,-0.023348916,-0.015709033,0.010262468,-0.0023947463,-0.040254492,-0.030011434,-0.029214483,0.03809757,0.0013677214,0.0069668484,-0.032037035,-0.049144126,0.047404367,-0.06368854,0.048561364,-0.008136915,0.04822447,-0.0833778,-0.06617758,-0.03692899,0.02816089,0.036968563,-0.041815724,0.038831603,-0.028761964,0.06011693,0.048242815,-0.034325697,0.02003848,-0.018466098,0.017181026,-0.0022187638,0.07201799,0.080609284,-0.025162162,0.10342493,0.038305108,0.05022912,0.018965906,-0.0097712455,0.004322748,-0.07248772,-0.083603516,0.052186888,-0.03617543,0.021127276,0.00743239,-0.045680866,0.054693498,0.046615943,0.009379504,-0.06279638,-0.08318441,0.0160795,-0.058423575,0.033763416,0.026428947,-0.045719393,-0.03832072,0.070855334,0.10466418,-0.011251586,-0.062469967,0.091898575,-0.06937969,-0.082906775,-0.036875457,0.05255963,-0.022331357,-0.033035785,0.010055543,0.0958833,-0.03486483,0.03312874,-0.095572405,2.2717369e-33,0.03272266,0.10023717,0.007565133,0.016730819,-0.08149061,0.04330689,-0.05908891,0.030975563,-0.119417205,-0.040860623,-0.040008817,-0.07707518,0.072063014,0.02864149,-0.080375016,-0.031133268,0.027786657,-0.0022179396,0.10951591,-0.026073843,0.044287596,0.08444658,-0.057878073,0.058846038,0.03788835,0.0439711,-0.021655077,0.050727665,0.054718815,-0.009965473,0.05987231,-0.079377696,-0.08090362,-0.012006594,0.01600914,-0.035107847,-0.035209637,-0.08317304,-0.03753151,0.008228445,0.050477955,-0.017411027,-0.006534973,0.041857097,0.059791613,-0.07505842,-0.037670407,0.039068572,0.040181406,0.03495734,0.030081667,-0.036779463,-0.018592894,-0.061281,-0.062893644,0.03096565,-0.008647674,0.03438919,0.060840495,0.011263361,-0.0012565252,0.0037553073,-0.050484415,0.008613908,0.036335487,0.03492091,-0.034379438,-0.08586686,-0.060252223,0.158973,-0.015658112,-0.031835858,0.0324981,0.09695825,-0.00043831056,-0.049391016,-0.044633716,-0.0045740097,0.062318794,0.007776945,-0.020667098,-0.04932976,0.01068315,-0.028621705,-0.039924152,-0.02073794,-0.0050322246,-0.09813505,-0.028446972,0.051347315,0.06624472,-0.08726344,-0.08096288,0.0024815726,-0.0042767753,-3.4059637e-33,0.11721328,-0.065400094,-0.044801053,-0.07507952,-0.031728514,0.018480465,0.08270458,-0.06587161,0.08334358,0.013726433,0.11146387,-0.02402726,0.029026786,-0.045287076,0.00061297044,0.0336359,-0.017268652,0.0031932346,-0.0002371498,-0.014784857,-0.044832934,0.1578485,0.083392836,0.049707,0.013369937,0.004868202,-0.035186302,0.07253723,0.0072671594,0.07290388,-0.03840322,-0.04776014,-0.045401677,-0.066836774,-0.078778155,0.025849663,0.010402878,0.0143408645,0.052840855,-0.0038666662,-0.020525247,-0.0021362773,0.025423117,0.08034424,-0.03529752,0.07867906,-0.04712403,-0.010541537,0.024372237,-0.09417007,-0.0067741247,0.04552165,-0.01572563,-0.019854225,0.0019393655,0.010985327,0.0007175392,-0.042234074,-0.0094613675,-0.06863613,-0.04781387,-0.07277377,0.055935167,-0.055745512,0.021061577,0.09448824,0.036205806,0.047070805,0.004767657,-0.003583083,0.050452583,0.046827585,0.035214487,0.0665765,-0.05442201,-0.0032976472,-0.0039608222,0.0065162396,0.03680042,-0.055017482,0.014866719,-0.028974837,-0.01781961,-0.023559496,0.044382878,-0.07421731,0.061167486,0.07637191,0.026499439,0.029009383,-0.060391154,0.016137442,0.014655664,0.021852031,0.11439076,-3.060617e-08,0.02023457,-0.05429167,0.026212782,-0.061557245,-0.007878767,0.05489216,-0.03486437,0.01715609,-0.015359303,0.03015812,-0.07865847,0.09574971,0.003205197,0.055130266,0.06097007,-0.008622061,-0.050190903,0.050429843,-0.036756497,-0.087847754,-0.068372585,0.0053087897,-0.032399897,0.04537145,0.025680156,0.0198677,0.057347327,0.037121426,0.03507861,-0.04625845,0.0037487275,-0.013913953,-0.041286025,0.002029346,-0.04377272,0.08910881,-0.037182834,0.006917505,-0.018870195,0.0834022,0.020399699,-0.035586774,-0.11045822,0.0580258,-0.054311875,0.028697846,0.009641208,0.005886513,0.0057315854,0.016088767,0.096965194,-0.045583494,-0.046040386,-0.040690072,-0.057972874,0.0022576384,-0.037679084,-0.04743819,0.05033005,-0.059247285,0.047321428,0.036073815,0.15922228,-0.062560596 +2.5.1.35,"This enzyme will also use as acceptor aspulvinone G, a hydroxylated derivative of the complex phenolic pigment aspulvinone E.",384,1.0,-0.0633235,-0.015021259,-0.050577857,0.05293107,0.036983047,0.047201127,-0.036424417,0.027043996,0.021644143,-0.053403262,0.07668872,-0.05522799,-0.0951405,-0.0056623975,-0.06803595,0.108024426,0.008955633,0.027901873,-0.031199615,-0.029108096,0.03403788,-0.03368196,-0.021485955,-0.0020915759,0.06350946,0.0028720049,0.035932705,-0.039953813,0.03277458,-0.10175823,0.004469766,-0.037758682,0.09085078,-0.0010972696,-0.0025113118,0.023552468,-0.053181242,-0.09581785,0.031054305,0.004246268,0.085685134,-0.023416303,-0.046863038,-0.008219834,0.00541797,-0.07866488,-0.026376149,0.048337158,0.07881537,-0.027151749,-0.062801234,-0.015976777,-0.06997289,-0.02700547,-0.020716025,0.109462194,0.023054503,-0.037947267,-0.024268607,0.07096541,-0.013163561,-0.089498065,-0.041573316,-0.013625523,0.024826005,-0.011817967,0.014583114,-0.06865826,0.037456963,-0.039697245,-0.045293964,-0.07162744,0.039808277,0.039217595,0.04254313,0.03751486,-0.04295003,0.050549917,0.030505562,-0.042003196,0.09852975,0.019061899,0.0323481,0.069819644,0.11087299,0.07390463,-0.051693574,0.054862343,0.040278167,0.07548589,-0.0015436121,-0.0022613076,-0.06935278,-0.074366406,0.00575457,0.03049451,0.09632721,-0.0058360673,0.040964726,-0.067914665,0.023246063,0.0022618733,-0.07830769,-0.073861964,-0.058790218,-0.024692453,0.01339605,0.035140406,0.033599067,-0.03441022,-0.030481387,-0.0717211,0.02415404,-0.036043078,-0.037228715,0.1075964,0.019065516,-0.023815915,0.0074295723,-0.025894769,0.047601275,0.0014378843,0.0010105823,0.046967465,-0.05323967,-0.0039435695,-0.021369379,3.2241228e-33,0.01887423,0.048114624,-0.04682293,-0.024343349,0.0019048575,0.052246694,-0.082946904,-0.018714176,-0.10310516,-0.15038624,-0.044098143,-0.06778415,-0.065984756,0.10453771,-0.037809577,-0.01127291,0.025571942,0.026083073,0.053739525,-0.033407502,0.05910334,0.030520838,-0.10100593,0.08377382,-0.09784504,0.008747511,-0.04399607,0.06610378,0.024184356,-0.040253356,0.05944341,-0.035152867,-0.047965247,0.031617302,-0.046275374,0.049394585,-0.012189003,-0.06371918,-0.013994517,0.053192277,-0.058367297,0.08215641,-0.014871546,0.012464511,-0.008295089,0.024979394,-0.031144777,-0.020155039,0.053928975,0.078001335,-0.043283205,0.027065221,0.008603506,-0.008308729,-0.019782744,0.063042514,-0.026003964,0.03719481,0.008055984,4.83999e-05,0.017896758,0.0643837,0.012734879,0.059159465,-0.020320602,0.07021571,-0.036706585,0.040134605,-0.0053118463,0.061004065,-0.03253515,0.00045174605,0.047886815,0.039780404,0.021786785,-0.017596658,-0.08127284,0.0018813595,-0.0019247358,-0.0024881936,-0.09381794,0.013746441,-0.020067913,0.008885404,-0.086674355,0.020067772,0.07194412,0.036519803,-0.010317102,-0.009934268,0.019227521,-0.11096781,-0.01783366,0.012605651,0.024466343,-4.7978254e-33,0.093734525,-0.082652524,0.04626276,-0.009654485,-0.061485328,0.051989865,0.017194066,-0.041390732,0.0494339,0.015679264,0.09408194,0.068199255,0.03004815,0.012219847,0.020135636,0.0288906,-0.065144196,0.121285245,-0.059990924,0.038964488,-0.05153427,0.038417157,0.059216622,0.07591523,0.04827719,0.02493059,0.012803352,-0.036563933,-0.0065709,0.07408611,-0.025995014,-0.00032192614,-0.038059052,-0.022459704,0.034878775,0.07371072,-0.029911544,-0.032538876,-0.06747455,0.072945274,-0.009653535,-0.0026388816,-0.014427816,0.0105424225,0.049596913,0.05028469,-0.027994258,0.010623891,-0.04729405,-0.061295,0.014536685,0.08396269,-0.063942805,0.0025984305,-0.01891361,0.044898067,0.07647447,-0.011138211,-0.07239331,-0.03036104,-0.08453744,-0.06592319,0.01926071,-0.025483284,0.006536756,0.021338977,0.02762285,0.07415556,0.028069312,-0.055112224,0.07333408,-0.009220476,0.06451661,0.1558232,0.03730465,-0.10464673,-0.015990868,0.01748821,-0.045223624,0.029377809,0.002426162,-0.025269985,0.016305918,-0.023140706,-0.005167539,-0.07182807,0.0054159276,0.08674261,0.0041808053,0.010488665,0.0017986884,0.02528337,-0.061648928,0.028043745,0.057237618,-3.1493297e-08,0.018111601,-0.05070242,0.115596555,-0.06664724,0.039747953,-0.0031918122,-0.021933995,-0.055639252,-0.02000534,0.0028858304,-0.101352245,0.013751538,-0.004198371,-0.0038431566,0.028693382,-0.020146023,-0.01705596,0.022348508,-0.0036785544,-0.0032529589,-0.12106136,-0.011333727,-0.05843566,-0.032585915,-0.029994803,-0.018840736,0.009178642,0.05225537,0.023334779,-0.004115522,0.060829405,0.029791584,-0.006847496,0.031035425,-0.06925454,0.02901386,0.0101018185,-0.07437754,-0.0315693,0.134635,-0.022472437,-0.11198656,-0.0065943226,0.018386519,-0.016308453,0.04365567,0.061695363,-0.04855144,-0.029151157,0.098529875,0.018908199,-0.08846896,-0.023243833,-0.015211015,-0.077232234,-0.049440637,-0.02467264,0.019412758,-0.03223793,-0.05825973,-0.023382736,0.0066976435,0.19168456,-0.06280409 +2.5.1.36,Part of the glyceollin biosynthesis system in soy bean.,384,0.99999994,-0.03906755,-0.04904981,-0.09995917,-0.03480383,0.05362681,0.093849935,-0.029900935,0.056157034,0.03884224,-0.008452804,0.077656955,0.04222844,-0.06043289,-0.16623333,-0.015261551,-0.065912805,-0.051903564,0.05350569,-0.062587395,-0.09752061,0.1013512,0.052815,-0.037722033,-0.017731123,0.008416044,-0.024128867,-0.0041295704,-0.09290096,0.02488963,-0.07228119,-0.019030223,-0.021533785,0.034727857,-0.026622966,-0.028686063,0.099497065,0.05334865,-0.10273685,0.0910061,-0.052919075,0.031101003,-0.013343762,0.019497328,-0.055851,0.012261243,0.038838044,0.050202157,-0.006925239,0.02570627,-0.06896473,-0.00211356,-0.04304583,0.024729216,0.02331616,0.025233163,0.04773773,0.012401207,0.0030015202,-0.019859474,0.105854094,-0.062669545,0.01763992,0.058984328,0.008626398,-0.0063363584,-0.0621122,0.051836908,-0.002247256,-0.030151056,-0.023012843,-0.014420666,0.00698521,-0.010697774,0.010054859,-0.06027389,0.1571911,-0.027363515,0.03262626,0.028162781,0.03319618,0.016817758,-0.062723644,0.08618888,0.08975213,-0.047255255,-0.00033146195,-0.051532526,0.023045082,-0.01716421,0.041532055,0.020709345,-0.037758082,0.029987663,0.048460312,0.0064641624,0.055255823,0.06569804,-0.07624516,0.010857165,-0.029754043,-0.039033487,0.02152316,0.06643487,-0.053221174,-0.05247966,0.060187664,-0.08196262,0.031109467,0.0038227702,-0.00057294714,0.0049721133,0.018917529,-0.012561646,0.054380164,-0.07948169,-0.023337118,0.045888767,-0.022907672,0.0077000186,-0.03145503,0.0680367,0.059636835,0.06941461,0.054991953,-0.095467664,-0.026011147,-0.0036468005,-4.0572757e-34,0.029990911,-0.0062404694,-0.02919086,-0.06506069,-0.040642463,0.022908183,-0.09352409,-0.074553244,0.020490598,-0.03370554,-0.043598477,-0.07122027,-0.034385983,0.035934657,-0.022256905,-0.008940911,-0.06774854,-0.056143437,0.08107828,-0.012170217,-0.052168973,0.027752183,-0.05555656,-0.036881622,-0.01567737,0.052314557,-0.025220612,-0.027667113,-0.032832373,-0.012359933,0.015164717,-0.043542784,-0.022525616,0.067940645,0.075762026,-0.061383337,0.026213503,-0.05560321,-0.021999985,0.09027962,0.023118207,-0.02201319,0.04941856,-0.047542114,0.029885877,0.060504004,0.035273753,0.033162385,0.11449793,0.06340646,-0.012268712,-0.034060095,0.095381275,-0.013995887,0.053936906,0.010806517,0.013026105,0.0092263,0.0033166958,0.08659412,-0.030884178,0.08488048,0.052284226,-0.026475295,0.027543323,0.05278295,-0.08380461,0.0033049665,-0.00315477,0.037137464,0.018489908,-0.059289485,0.08091818,0.036904037,0.058494586,-0.043335453,0.028435752,0.09406098,-0.056974743,-0.0017838668,0.09406572,0.04506306,-0.052294582,0.005997408,-0.012874129,0.111457095,-0.070540704,-0.03503127,-0.014442576,0.01697948,0.053746887,0.037206374,-0.053899452,0.034347877,-0.07215103,-7.3006253e-34,0.06208147,-0.05647901,0.071176976,0.033467896,-0.015943008,0.025619585,0.02731494,-0.042658947,-0.010877881,-0.0036185284,-0.040704235,-0.021010416,0.00018421514,-0.034550194,-0.054062545,0.010480695,0.0064535025,0.033838313,-0.05141433,-0.023015201,-0.027645722,0.028065221,0.014292293,0.01930648,0.10551277,-0.016797232,-0.013686622,0.0650541,-0.06840522,0.0017863004,0.018663585,-0.07182299,-0.089922994,-0.019551286,-0.01303437,-0.037489694,-0.06998398,0.048043743,0.04909575,-0.06642279,-0.05397159,0.024863314,0.04471581,-0.05502278,0.023055123,0.032846328,-0.04930033,0.016092243,-0.03545098,-0.0022800958,-0.058166042,0.04079596,-0.005963019,0.03495838,0.01472042,-0.0009963248,0.0653315,0.03086494,0.05316053,0.02477496,0.037548523,-0.10037781,0.04227419,0.020992221,0.05508651,0.044928942,-0.013074774,0.03680425,0.042330213,0.055272665,0.051709644,-0.094190516,0.1048565,0.054817658,0.046636116,0.017520258,-0.05841154,-0.07748212,-0.02619563,-0.045969985,-0.033627983,0.053052034,-0.069722876,-0.09987913,-0.0066618067,-0.022844065,-0.052500058,0.10896332,0.10061626,0.013663539,-0.03167342,0.005714567,-0.06815812,0.021488225,0.050954137,-1.9744622e-08,0.01797888,-0.06296297,0.046471808,-0.051420618,0.021884026,0.04276803,-0.025647018,0.022245998,0.0014732151,-0.044582855,-0.040915385,0.068219766,-0.05174487,0.014799935,-0.07359873,-0.0024665724,-0.02959963,0.103598095,0.009991263,0.011288486,-0.03863077,-0.025481647,-0.115554586,0.004946292,0.026499003,-0.061462004,-0.03632853,0.08204591,0.068878934,-0.011053474,0.01994683,0.017992128,0.014471114,-0.116981566,-0.06431691,0.0047454354,-0.06978065,0.025753198,-0.032953046,-0.035480637,-0.034751493,0.0022885264,0.06957961,0.03858597,-0.044357177,-0.006979549,0.037194137,0.10249976,0.021661196,0.050459396,0.014970565,-0.04104071,0.00079199916,-0.011479187,-0.07805759,-0.08376241,0.03704409,-0.078239195,-0.020349942,0.010523709,-0.119075306,0.0010019587,0.120359175,-0.015005311 +2.5.1.38,"The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the beta-lactam antibiotic nocardicin A. The enzyme can act on nocardicin E, F, and G, producing isonocardicin A, B, and C, respectively. However, the in vivo substrate is believed to be nocardicin G [3].",384,1.0,-0.018095262,-0.029440269,-0.101274684,-0.0025295,0.006591298,0.015379773,-0.051031087,0.0022203538,0.028086632,-0.05354379,0.07888516,-0.026013663,-0.019389128,0.09401811,-0.033349074,-0.041387327,-0.028084995,-0.008414799,0.0074726827,0.026885986,0.0074574105,0.09022816,0.011621026,0.020157514,-0.01838406,-0.010263971,0.049048625,-0.0909826,-0.0028540166,-0.0998065,0.053847596,-0.028828742,0.15489472,0.0020232857,0.03651195,0.0065530557,-0.023618469,-0.04275808,0.06103767,0.027987713,0.029092984,-0.011812038,-0.008550599,0.014572966,0.06504834,0.011435006,0.015183065,0.06519279,0.020468952,0.042638525,-0.038707085,-0.08051657,-0.038310416,0.004189972,0.023964105,0.011545221,-0.09215321,-0.104447484,-0.026240343,0.00049732433,0.05350526,0.041867062,0.01285759,0.01301734,0.0073141796,-0.014906438,0.052271582,-0.077177554,0.05725122,-0.03899825,-0.0012116986,-0.08809305,0.03038677,-0.031233534,-0.002120895,-0.008085147,-0.029655853,0.036011692,0.024403403,0.010610782,0.005431317,-0.059740704,-0.022366496,0.10174094,-0.035043243,-0.023541532,0.009939014,0.066948675,0.080621846,0.008001982,0.012644088,0.03759689,-0.006681901,-0.038766984,-0.069143064,-0.048578907,-0.06238158,0.04852608,-0.036596335,-0.036908615,-0.0137976315,0.012195712,-0.07158622,-0.03411216,-0.021487778,0.019913167,0.058808923,0.00349902,0.06291813,0.008161385,0.02085969,0.0016107863,-0.013160915,-0.035441086,-0.058076542,0.048534885,0.044796295,-0.09023571,-0.07547438,0.11818182,0.020269528,-0.03311193,0.00158202,0.037993364,-0.096173875,0.1210368,-0.031788144,-2.5736005e-34,0.03028125,0.03053996,0.048430618,-0.06584266,0.080797754,-0.012199793,-0.08679769,-0.004627457,-0.018789241,-0.07806932,-0.08838135,-0.047588535,0.006951158,0.0519735,0.04660424,0.030177386,0.010754387,-0.027784957,0.09393908,0.047857635,0.008031231,0.050204955,-0.059201114,-0.010104719,0.027297184,0.11839999,-0.025004897,0.03844803,0.024920015,-0.033870578,0.0199514,-0.124084085,-0.012365624,0.044848178,0.10030669,0.045046423,-0.022057183,0.056678213,-0.014799154,0.07688227,-0.012227771,0.012055459,-0.016466876,-0.07164119,0.08708698,-0.038825776,-0.0060628885,0.100790374,0.065427184,0.05536205,0.10605744,-0.016382383,0.064748555,-0.030072823,0.0059816944,0.04816978,-0.030172588,0.10291231,-0.0032903315,-0.036204077,-0.022003418,-0.038075753,-0.04433599,-0.016705632,-0.025209747,0.014966568,-0.07658682,-0.059558526,-0.012998765,-0.008859411,-0.05488669,0.015367,-0.0394683,0.054632336,-0.032969758,0.049568724,-0.08505929,0.07280966,0.06857694,-0.04355646,-0.06612315,0.054931995,0.0010382704,-0.068696946,-0.032362726,0.0010710594,0.0087187905,0.03003014,0.0068172915,-0.010757568,0.047185473,-0.036555104,-0.09017004,0.03354397,0.082868196,-1.8568166e-33,0.076177426,-0.111810416,0.04608324,-0.066753626,-0.040317323,0.069271564,-0.03002673,-0.0052957963,0.052054804,0.04612609,-0.011081358,-0.02383649,0.014824099,-0.052729875,0.023969494,0.025188768,0.04445558,0.085735105,-0.038108315,0.0031161057,0.02982219,0.07454627,-0.018588614,0.0124391215,-0.0010891396,0.07937031,0.03833622,0.09535833,0.048756752,0.041484594,-0.008390387,-0.015649162,-0.03350039,-0.092261635,0.003137386,0.08366541,-0.017518315,0.110256195,0.042679228,-0.069615945,-0.014150164,0.062600546,0.05511714,0.081347466,-0.015273639,0.021189716,0.0023367463,-0.056173544,-0.075276226,-0.065659426,0.017901521,-0.057196777,0.00583669,0.014156617,-0.012512567,0.07203034,-0.012067476,0.070223905,0.027111853,-0.069572665,-0.008480037,-0.11281922,0.042663485,-0.047596868,0.011351776,0.012029234,-0.054196563,0.03051059,0.06584004,-0.09767717,0.0018205895,0.021018911,-0.06785426,0.06720976,-0.0882751,0.032702204,-0.033027496,-0.09881266,-0.017777642,-0.032724798,-0.044722363,-0.010162947,-0.03194928,-0.018304685,-0.008772824,-0.008358291,0.11474575,0.034197636,0.039192848,0.022015113,-0.009302057,0.045114674,-0.09475179,0.04892938,0.0010320134,-3.5490974e-08,0.010752407,-0.104473904,0.047759842,-0.0608243,-0.0682374,0.011811857,-0.001788382,-0.0739063,0.040242378,-0.049348306,0.02176277,0.09881861,-0.027849155,-0.003179969,-0.0028889524,-0.034854643,-0.033679806,-0.011064136,-0.050599176,0.0114086885,-0.05995138,0.022709236,-0.039541986,0.012388978,0.0036159426,-0.09686649,0.026501274,-0.015809223,-0.0037000393,-0.013579729,-0.018418131,0.024801137,0.04181489,-0.06895565,-0.10352942,-0.06298465,0.04610784,-0.035931714,0.03710436,0.025422325,0.019562079,-0.04349961,-0.06527978,-0.033872776,-0.041212916,-0.05572099,0.0098385345,-0.014049004,-0.020897174,0.022136655,0.06064065,-0.06352221,-0.07040084,-0.00076935574,-0.11597813,-0.042119298,-0.0025634426,-0.0069824974,0.01365303,-0.038190644,0.01316126,0.006048724,0.1774009,-0.004878362 +2.5.1.39,"This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency [2,4,5].",384,1.0,0.016782736,0.01816873,-0.034508094,-0.03556236,-0.044109102,0.01181567,-0.028718064,0.037224334,0.0070287646,-0.115938306,0.037100542,0.0063631786,-0.03341199,0.0011302795,-0.062134042,0.050007302,-0.044225328,0.0048805824,-0.033709772,-0.017696902,0.07812472,-0.051502805,-0.009225725,-0.005242655,0.0024322264,-0.035589423,0.044270188,0.018020986,0.0029342598,-0.06580485,0.010748979,-0.056969237,0.021047242,-0.07806961,-0.021124646,0.078185484,-0.04072609,-0.0012560377,0.03099384,0.057167057,0.09234481,-0.08402419,-0.009265277,0.08780708,-0.0067973365,0.021614816,-0.072492324,0.10232659,0.09090701,0.0063885525,-0.027183011,-0.019702794,0.037261046,0.093204446,0.006487052,0.08926647,-0.053518515,0.039856303,-0.035049565,-0.015431899,0.06209573,0.05057616,0.007456583,-0.005834945,0.01109601,0.0189041,-0.021632604,-0.029111413,0.031455737,0.03301317,-0.022326503,-0.013631048,-0.12548366,0.008553404,-0.0450675,-0.001603638,-0.046649836,-0.010027124,-0.008516523,-0.045975707,-0.008157364,-0.018055912,0.078039564,0.053102724,0.036877844,0.06779104,0.07027017,-0.032886162,0.019416055,0.054670967,-0.010228773,-0.05536214,-0.0022839722,-0.009126985,-0.0432772,0.035002984,0.05871584,0.06260654,-0.021973293,-0.018818257,0.041208267,-0.03935726,-0.04086832,-0.115773514,-0.034671266,0.02919688,-0.012173344,0.036617,0.016848464,-0.012538621,-0.04328079,0.005678437,0.0152237825,0.012534094,0.005411029,-0.004740771,0.009157461,0.021261027,-0.032808308,0.007329835,-0.03337123,0.06793189,0.010721682,0.036819793,-0.0074355886,-0.0020085934,-0.11688208,1.24837445e-33,0.027005434,-0.008683653,0.014876473,-0.02726277,-0.08411786,0.011225079,-0.06487408,-0.01630526,-0.15572731,-0.024697838,-0.06477926,-0.022409387,-0.0031927906,0.044260077,0.05136274,-0.063832566,0.053299766,-0.013370865,0.11395042,-0.03814927,-0.07661342,0.0018358489,-0.054713216,-0.0586257,-0.014522634,-0.0031050027,-0.043199074,-0.007629906,-0.023589313,0.029048054,-0.054708447,-0.057372324,-0.08808268,0.035906076,0.0094043575,-0.045914434,-0.054201446,-0.042814143,-0.016694708,0.012787516,0.027360355,0.0530779,0.005773581,-0.041420426,0.074462675,-0.034829017,-0.016731238,0.18020889,0.061340053,0.0075868135,0.03496084,0.0552996,0.07897213,-0.039070647,-0.0958903,-0.015566615,0.014028814,0.022071647,-0.011851935,0.03469965,-0.025868362,0.093106754,-0.052121103,0.013071042,0.007030616,0.057930075,-0.032816228,-0.026078774,-0.0040099975,0.031543598,-0.048764154,-0.06100754,0.013818714,0.073203176,0.026746089,-0.0393854,-0.04148015,-0.06015364,0.11654889,0.0023406378,-0.068832405,-0.0311259,0.007657141,-0.05569021,-0.018517664,0.01646791,0.05743129,-0.05153142,-0.03588032,0.053270757,0.07243999,-0.077011585,-0.034820236,0.07889,0.066070594,-2.7437879e-33,0.052424103,-0.096183635,0.08047245,-0.02190643,0.017215602,0.037072122,0.007476547,0.02212282,-0.034183647,0.043946467,0.12103004,-0.014300258,-0.02254752,0.026869,0.022062937,0.029251534,0.0005321072,0.033580475,0.07608105,-0.056543536,0.041739784,0.020169182,0.004415792,0.069166526,-0.04339882,0.02561742,0.06272244,0.015057547,-0.028964512,0.05683969,-0.05640103,-0.025320033,-0.052867368,0.029280145,-0.046839856,0.03017381,-0.07807064,0.06250023,0.10223745,0.0113002425,-0.019217515,-0.02013846,-0.0061303745,-0.006695241,0.03807406,0.07907636,-0.043303482,0.06734493,-0.057657797,-0.07720735,0.036310513,0.06081155,0.019337,0.044938505,-0.021801377,0.021520708,0.0024057103,-0.004999171,0.061331116,-0.060506642,-0.02147055,-0.034063987,0.06473076,0.014012736,0.005088161,0.05599966,-0.0066975607,0.031181058,-0.039775815,-0.060526665,0.089352034,-0.018847348,0.019424083,0.023348536,-0.051176947,0.00548781,-0.046177804,-0.0975926,-0.04400361,0.004585516,-0.03502238,-0.011979184,-0.007545748,-0.07714117,-0.021986527,-0.08538916,0.07825961,0.09006873,-0.023176204,0.10626723,0.03899133,0.101280704,-0.10837101,0.01931655,0.13362579,-3.6929638e-08,0.07126822,-0.043154262,0.07760803,-0.07918337,0.0071135107,0.023761619,-0.0123515455,0.0339664,0.022533916,0.0040571867,-0.0024367713,0.05558945,0.002243238,0.07964641,0.022945063,-0.0087085795,0.034325607,0.0022648575,-0.0155468155,-0.078332275,-0.08490643,0.029439362,-0.07608614,-0.064399645,-0.039067138,-0.09873072,0.04069253,0.047527738,-0.014703175,-0.038039353,0.05529906,0.029751275,-0.07004793,-0.06153021,-0.059609793,0.096545495,-0.06898883,-0.06625994,0.012190811,0.017822413,-0.032086395,-0.07457103,0.0139289405,0.040405076,0.059306208,-0.026139166,0.061975848,0.010337651,-0.028869195,-0.002817719,0.02414702,-0.07318259,0.05608271,-0.12590377,-0.033982668,0.06496663,-0.07363737,-0.028077884,-0.031144077,-0.071961634,-0.037570816,0.0018642088,0.15524662,-0.040007014 +2.5.1.41,"This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria [2]. Requires Mg2+ for maximal activity [2]. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5].",384,0.99999994,-0.07797929,-0.06519151,-0.06833862,-0.046139788,0.030996712,0.023279294,-0.12089618,0.0018243577,0.054078855,-0.0070606438,0.023600353,-0.0265847,-0.036832575,0.01881608,-0.021722546,-0.011997076,-0.056533944,0.026545454,-0.0009884741,0.015767695,0.12939247,0.05393402,-0.08052561,0.038055126,-0.024185613,0.00942335,0.0249116,-0.10308475,-0.045674693,-0.014085691,0.04265658,-0.06248338,0.10692307,-0.05321925,0.035666306,0.10929291,-0.041971553,-0.00083973096,0.028432125,0.00037992594,0.07657237,-0.032214817,0.027550463,-0.0626421,-0.050184526,0.007869038,0.037534222,0.013115453,0.010584688,-0.028664086,-0.0420774,-0.05318171,-0.06668336,-0.031495847,-0.0086252,0.07441181,-0.075142615,-0.0736144,0.015038808,-0.06358737,0.023145527,0.013455411,-0.008046986,-0.008255219,-0.006114965,-0.090533204,0.08673873,-0.07840978,0.07926581,0.014480148,-0.051259805,-0.051442616,-0.008583124,0.013697626,-0.06626993,0.07413027,0.009040321,-0.0006220298,0.01375911,-0.08160655,0.07099413,-0.018688291,-0.048618276,0.060442872,0.052540436,-0.042971876,0.008365652,0.052480023,0.06199114,0.02086924,0.069544636,-0.040656455,0.04106254,-0.03273367,-0.01970323,0.038363256,0.042138025,0.002436472,0.0030124458,-0.0364162,0.040444862,0.03637775,-0.019421062,-0.10364647,-0.031486288,-0.019911643,-0.019535622,0.11223183,0.023855109,0.041558895,0.016136002,-0.0472023,0.07909892,0.027933897,-0.031848975,0.09807607,0.02159126,-0.059605133,-0.0729631,0.07133091,-0.03818294,-0.0536526,0.057264943,0.055575404,-0.036367465,0.12143118,-0.08564706,5.477062e-33,0.08916895,0.0101301875,-0.0012526258,-0.05796378,0.0086667435,-0.015135026,-0.063846014,0.020259237,-0.05136349,-0.03443733,-0.02981006,-0.053131618,0.042699564,-0.004827721,-0.08681901,0.022090487,-0.012351135,0.02467325,0.076060265,-0.007049414,-0.05720903,0.060358148,0.008193483,-0.045458253,0.030192254,-0.02095192,-0.024080828,-0.07469768,0.04324153,0.006528643,0.021430004,-0.16258596,-0.09142837,0.035728194,0.117457874,-0.020402942,-0.00086423213,-0.05369579,-0.02076347,-0.009275759,-0.023402812,0.043855835,-0.022024838,0.006151746,0.02089158,0.0027199609,-0.06402778,0.086934775,0.04077624,0.03751274,0.03836944,-0.010785064,0.063141644,-0.014431633,-0.09949575,-0.042603888,-0.028214635,0.03715412,0.028035942,0.016467605,0.014659627,0.10224449,-0.044545196,0.030299377,0.07719226,0.025995225,-0.06675396,0.010616888,0.008918102,0.030220574,0.00491705,-0.039322227,0.092270054,0.08623953,-0.0021906395,0.0050593074,0.00045009455,0.0446165,-0.0060690376,0.03973943,-0.03463142,0.04608399,-0.006348441,-0.012077114,0.004253588,0.036654655,-0.006260181,-0.036767393,-0.00622511,0.062135395,0.041992914,-0.06401637,-0.038426045,0.09782342,-0.037287496,-6.126329e-33,0.0151349865,-0.106100656,0.006417942,-0.08884826,-0.06574496,0.062148876,-0.0028657087,-0.033479176,0.050360497,-0.079384476,0.047203887,0.013612595,0.06945449,-0.035868887,-0.009541888,-0.07716913,0.041243076,0.05128425,-0.021703565,0.02453502,0.09429337,0.03374051,-0.022419285,0.09673383,0.033783507,-0.0073207854,0.036825553,0.097429164,-0.0045139687,0.09026198,0.059089545,0.083851576,-0.08650154,-0.07101258,-0.10452359,0.04270601,-0.08235823,0.03465066,0.043417946,-0.02233433,0.007330617,0.04420794,0.03396187,-0.008829906,0.055823684,0.0051226723,-0.00043254532,0.017789444,0.004484484,-0.06408042,-0.06884818,-0.038472705,0.021941857,0.04708875,0.027318606,0.03580757,0.013651489,0.085181005,0.037327442,-0.09709976,-0.047260303,-0.025216937,0.0013259252,-0.08602535,0.03431268,0.068717465,0.02072876,0.008455083,0.0072680516,-0.013292549,0.0113081485,0.028215852,0.047734622,0.044180915,0.04813048,0.051666796,-0.019589772,-0.0892122,-0.007152128,-0.07742518,0.0089414185,0.061223306,0.028519357,-0.11341689,-0.0061038677,-0.047404062,0.09223598,0.100782044,-0.01224517,0.012807639,0.016309295,-0.059336517,-0.068503454,0.018388914,0.072922945,-4.9562267e-08,0.02909093,-0.034954734,0.03250051,-0.052500363,-0.043210845,0.042358305,0.06109252,0.033320148,0.05179185,-0.11623869,0.0047995043,0.05330494,0.016082432,-0.031723056,0.011180247,0.050669648,-0.031066932,0.017752843,-0.02694129,-0.076972984,-0.034276035,-0.08244811,-0.043314688,0.055584755,0.019531656,-0.08085914,0.04035253,-0.0017159027,-0.021006802,-0.056243096,0.012442959,-0.018364087,0.002956403,0.037431385,0.016757837,-0.0048506972,-0.06670571,-0.015185783,0.007927957,0.016989643,-0.022177938,-0.008326457,-0.069798514,0.002181635,-0.002428403,0.02306885,-0.038777653,0.10363843,-0.04999719,0.037526432,0.035682622,-0.03692286,0.010486002,-0.09545138,-0.069397636,-0.04354244,0.017769108,-0.050562117,-0.052133147,0.024141803,0.035102542,-0.010607659,0.102863245,-0.02599076 +2.5.1.42,"This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity [2]. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and alpha-glycerophosphate cannot act as prenyl-acceptor substrates [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 [CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase] to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [3]. Belongs in the UbiA prenyltransferase family [2].",384,0.99999994,-0.03950091,-0.058320954,-0.091529325,-0.033277333,0.044313412,0.011360544,-0.09815269,-0.01706045,0.0410882,-0.015758794,0.013893073,-0.05377943,-0.030431539,0.028106632,-0.009470506,-0.010770803,-0.030958844,0.011683306,-0.014837686,0.023389857,0.11886636,0.05316925,-0.04262656,0.015328316,-0.031343576,0.014722721,0.03922294,-0.08801695,-0.053674556,-0.027626246,0.038830034,-0.07150152,0.10574417,-0.047754973,0.024648,0.1147662,-0.030041091,0.0050863638,-0.006328813,0.019300383,0.052633744,-0.03222651,0.060809642,-0.08821892,-0.021560784,-0.026843077,0.06432874,-0.016043684,0.026416333,-0.018671906,-0.04664426,-0.05581505,-0.028699055,0.006202139,-0.0076689213,0.06438075,-0.07126486,-0.03992361,-0.0228531,-0.051318105,0.033091657,-0.0043636495,0.009509919,-0.022320291,-0.050941344,-0.045794617,0.061398957,-0.08498478,0.07730029,0.017455216,-0.047827523,-0.036131512,0.013206395,-0.008877858,-0.049137846,0.079716094,0.039715458,0.0038339605,0.029968,-0.09481882,0.026058227,-0.044405013,-0.03074594,0.054588087,0.028829288,0.01981132,0.037851904,0.030595172,0.054870524,0.039037168,0.077256076,-0.014019594,0.072778806,-0.022640103,-0.03195323,0.036194995,0.033223085,0.04032852,0.022925504,-0.031647734,0.05512008,0.032114197,-0.03742314,-0.08920295,-0.03632689,-0.02101162,-0.0058016125,0.11515532,0.0185377,0.052658115,0.018802822,-0.041376162,0.09251744,0.08210093,-0.00019252878,0.104055494,0.012608852,-0.08905993,-0.037469283,0.06544855,-0.018175626,-0.02871005,0.058368538,0.06509298,-0.012991293,0.10303173,-0.11749123,3.87719e-33,0.09102878,0.038011037,0.0074915956,-0.057936568,-0.025032189,-0.013875809,-0.08761284,0.019303685,-0.05970649,-0.044776037,-0.033643704,-0.0070374534,0.05002244,0.0015587582,-0.06363388,-0.0070450488,-0.01511274,0.021130096,0.10344613,0.007828921,-0.058011524,0.052890785,-0.025142763,-0.06254466,0.048354365,0.013243517,0.021981155,-0.07083772,0.020758403,-0.004050906,0.0052588936,-0.17819877,-0.073439986,0.03777541,0.11816681,-0.027690656,-0.008617384,-0.02075802,-0.046287943,-0.02068033,-0.026107397,0.030589787,-0.042868283,0.023831988,0.054957613,-0.048957568,-0.061173696,0.107307635,0.045788024,0.04935515,0.021045642,0.030621445,0.07872417,-0.007803017,-0.11694425,-0.030230312,-0.040804803,0.0518792,0.055856038,0.029970242,-0.033245575,0.102567166,-0.03490465,-0.0044183503,0.06691024,0.007219128,-0.04950198,-0.010162937,-0.011487012,0.0020108528,0.022438021,-0.089460105,0.09236276,0.09038086,4.588672e-06,-0.00428486,-0.00017614148,0.0155941155,0.03055196,0.033101905,-0.05435048,0.01929423,0.0098851565,-0.012737248,-0.062827215,0.049927995,0.001558474,-0.03762638,-0.021409573,0.07132724,0.008783421,-0.04675275,-0.038944434,0.07416727,-0.034376748,-4.888562e-33,0.030271817,-0.10142953,-0.0028000039,-0.07522844,-0.07834934,0.075042136,0.0098254355,-0.02727578,0.05221851,-0.06967568,0.08041035,-0.004218387,0.08801237,-0.05612848,0.013167873,-0.066467665,-0.0035617144,0.03539864,0.03871112,0.021581082,0.08271787,0.052135132,-0.038750727,0.123573504,0.013312656,0.018984117,0.064494625,0.06767423,-0.024470868,0.09091189,0.02819097,0.0633149,-0.06988232,-0.05586019,-0.088266015,0.0343792,-0.09043514,0.003039721,0.032808237,0.004893422,-0.003761316,0.007196654,0.025257532,-0.000997807,0.033729043,0.014522477,-0.03803348,0.059830848,0.000774476,-0.042284828,-0.077896625,-0.03589372,0.0032814103,0.038181342,0.050458178,0.02437521,9.141798e-05,0.07074973,0.036476925,-0.05301961,-0.055578005,-0.04666067,0.0477196,-0.07305032,0.025796369,0.054170787,0.015570758,-0.017569888,0.009993464,0.015236335,0.033577625,0.007622032,0.013437754,0.05283036,0.039945047,0.037801515,-0.010577863,-0.07601382,-0.023758464,-0.077654876,0.018263448,0.07625748,0.046781804,-0.10148322,0.009037516,-0.054568574,0.10050081,0.084308356,-0.028057717,0.03139644,0.019485394,-0.06129095,-0.10007115,-0.005641204,0.040115003,-4.7489173e-08,0.028591353,-0.039251447,0.06803715,-0.06767352,-0.06570624,0.0114230225,0.07504132,-0.0012432003,0.02537346,-0.08200625,0.01527884,0.032598075,0.040776957,-0.020402139,0.0032539184,0.048542168,-0.01384869,0.018330723,-0.031238059,-0.07497462,-0.00924242,-0.09555201,-0.07873697,0.014352681,0.030356584,-0.08293553,0.026918493,0.009416201,-0.018619915,-0.05210719,-0.0054052556,-0.016756114,0.027771728,0.007603948,0.037501745,0.0045033926,-0.06921056,-0.024923403,-0.055465817,0.020946557,-0.053863376,-0.025964413,-0.04780917,-0.0011524429,0.010841692,-0.00024764342,-0.02388526,0.09723452,-0.0210675,0.025640085,0.041179676,-0.030498384,0.03830853,-0.11432853,-0.0932056,-0.005396198,-0.008129335,-0.072644375,-0.04683065,0.032057792,0.055715613,-0.015464776,0.09568586,-0.055226386 +2.5.1.44,"The reaction of this bacterial enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of either putrescine or spermidine, forming 4-iminobutan-1-amine or (E)-(4-aminobutylidene)(3-aminopropyl)amine, respectively, (b) attack by water forming 4-aminobutanal (and releasing ammonia or propane-1,3-diamine, respectively), and (c) condensation of 4-aminobutanal with putrescine, which forms homospermidine and restores NAD+. Differs from the eukaryotic enzyme EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group.",384,1.0,-0.05400466,-0.037092578,-0.043365896,-0.096875384,0.048431262,0.11859823,-0.08931463,0.07359337,0.008909958,0.06458137,0.031704333,-0.02021577,-0.001532318,0.11839064,-0.02164097,0.023397487,-0.07716464,-0.084674396,-0.008646142,-0.01931667,0.04324047,0.027817348,-0.06131578,-0.051426105,0.031622883,0.043476425,0.032758664,0.014162906,0.019542914,-0.02788994,-0.041620634,-0.042439234,0.0039857733,-0.10541693,0.02013381,0.056048088,-0.06351662,-0.014559689,0.062975116,0.03534557,0.026000353,-0.0025836085,-0.06727044,-0.006207064,-0.027487248,-0.008117937,0.11457166,0.05273344,0.08428915,-0.020961538,-0.053243395,-0.0025914449,0.027115734,0.015151277,0.0769686,-0.06392717,-0.026314568,-0.010089728,0.0007718903,0.00035744382,-0.01738786,-0.008413112,-0.01806177,-0.086286336,0.06892909,0.0005017533,0.0060289414,-0.046187997,0.018640976,-0.021201914,-0.046861287,-0.055520333,0.04132919,0.08619258,-0.0031963985,0.011714274,-0.044167273,0.009468779,0.012042467,0.01155921,0.009282458,-0.11051467,-0.08662127,0.019038072,-0.015155037,0.036659,0.002228147,-0.008930571,0.095242016,0.0137659395,-0.054747947,-0.019529603,0.02124324,-0.036623754,-0.04388657,0.006916595,-0.054524258,0.049977563,0.04592829,-0.010654608,0.010988919,0.08329158,-0.03663229,-0.07551267,-0.041406367,-0.014523357,0.026458036,0.13166095,-0.027453622,0.056204267,-0.0066089975,-0.029247113,0.031815186,0.014237782,-0.06814447,0.09526606,0.031100033,-0.027046837,-0.081686765,-0.053141534,0.056664526,0.028782802,0.12678081,0.057243884,-0.012307097,0.020555718,-0.103382334,2.658482e-33,0.087799735,0.008910729,0.04415286,0.055114295,0.051748972,0.048422158,-0.0721449,0.053432286,0.07176287,-0.10153373,-0.0614615,-0.09872278,0.039540842,-0.0017457549,-0.07186059,-0.048105188,0.0031805485,-0.08025863,-0.010549743,0.06792389,0.028192278,0.07402247,-0.025434744,0.0438431,0.037088014,-0.03732323,0.011604743,0.045306534,0.06486044,-0.021122871,-0.005747476,-0.077071875,-0.12892555,-0.06011934,0.070947014,-0.029487614,-0.06073664,-0.04516038,-0.004611665,0.06711652,-0.051956728,0.035126917,-0.031097937,-0.0127223935,0.054526422,-0.07554736,-0.01195246,0.10774237,0.023272408,0.010600421,0.027035866,-0.026878716,0.0986922,-0.039339717,-0.08274876,-0.01654382,-0.016354894,0.0025514048,0.020871809,0.07816709,0.040987797,0.0014028447,-0.0049633817,0.05047882,0.0054940856,-0.013002839,-0.10079998,-0.013707098,0.047632568,0.0546192,-0.03204139,-0.004176473,0.051715504,-0.0073254975,0.00237895,-0.09718061,-0.11852155,0.036568288,0.062747456,-0.06047414,0.028400479,0.008619612,-0.02812771,0.0013670296,-0.058164716,0.04045779,0.0025254895,-0.052782323,-0.022685189,0.013797356,0.072618045,-0.09407922,0.0145489415,-0.018727234,0.069092184,-4.731777e-33,0.07455076,-0.11571331,0.016088825,-0.047027808,-0.0017841288,0.08572794,0.08641721,0.016723514,-0.037949815,-0.082830384,0.03631552,0.029681157,0.055895623,-0.0042239274,-0.046576567,0.017755967,-0.01629978,0.037079163,-0.0019401433,-0.0284097,0.02065559,0.0005885462,0.031239206,-0.011705622,0.057503346,-0.01167857,0.034398362,0.063855164,0.0085981125,0.08337846,-0.011555417,0.008897765,-0.06580737,-0.020816382,-0.0019091306,0.055648208,-0.01716659,-0.024171853,0.019802447,-0.009326412,-0.020340115,-0.013021043,-0.02217116,0.049467992,0.011789975,0.10723342,-0.08115914,0.03535365,0.01870987,-0.050669625,0.038413405,0.0008105482,-0.03487352,-0.0075920196,0.00011997329,-0.04857733,0.024014663,-0.029584274,0.011891002,0.041954152,-0.065979876,-0.061164364,0.013904326,0.0057114507,0.036693275,-0.009388343,-0.03393174,0.07318568,0.063103415,-0.046303842,0.043998387,-0.081683785,0.06973449,0.009020079,0.012699133,-0.0026238137,-0.083976306,-0.023342492,0.005476054,-0.024358872,-0.040147092,-0.059723757,-0.059326258,0.015376598,-0.01709519,-0.061111446,0.10670291,0.07386024,-0.029330553,0.03986754,-0.021224638,0.031637542,-0.016598444,0.1124687,0.056585107,-5.102647e-08,0.08633482,-0.052752696,0.04371111,0.021691704,0.019524736,0.038940623,-0.050531477,0.010920178,0.05350614,-0.05143449,-0.062300924,0.042291112,0.0064622303,0.043248568,0.029414421,-0.0042621708,-0.01982817,0.02008358,-0.036119018,-0.029599344,-0.098569505,-0.039677713,-0.14008981,0.018503617,0.0024920183,-0.015926285,0.029657524,0.02177182,-0.00991408,-0.101184085,-0.0337848,-0.015881846,-0.014198392,-0.07608267,-0.09308529,0.026754407,-0.049391314,0.022448346,0.02415227,-0.015561476,0.06394696,-0.028150393,-0.07297139,0.021503482,0.09824241,0.03452585,-0.00010758559,0.028849918,-0.09843541,-0.014896883,0.015462171,0.054693293,0.056059126,0.0042259623,-0.062181085,0.026447207,-0.08826602,-0.06541753,0.047316138,0.021850133,-0.024663493,0.034258496,0.109976664,0.03402655 +2.5.1.45,"A eukaryotic enzyme found in plants. The reaction occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of spermidine to 4-iminobutan-1-amine, (b) attack by water forming 4-aminobutanal (and releasing propane-1,3-diamine), and (c) condensation of 4-aminobutanal with purescine, which forms homospermidine and restores NAD+. This enzyme is more specific than EC 2.5.1.44, homospermidine synthase, which is found in bacteria, as it cannot use putrescine as donor of the 4-aminobutyl group. Forms part of the biosynthetic pathway of the poisonous pyrrolizidine alkaloids of the ragworts (Senecio).",384,1.0,-0.06110697,0.00027435072,-0.075699165,-0.056860715,0.048727404,0.10495145,-0.09295532,0.076095946,0.041696068,0.048031464,0.067805566,-0.07307837,-0.01088815,0.042485684,-0.0411168,0.05682712,-0.1179941,-0.03540498,-0.013975204,-0.0027304434,0.029029563,0.036976665,-0.050347745,-0.040763024,0.014850493,0.017483266,-0.013008352,-0.010848013,0.019867346,-0.032656625,-0.029503059,-0.028497111,0.017664993,-0.07923794,0.025263237,0.026188392,-0.055478547,-0.016247189,0.07095653,0.061055988,0.05579916,0.008652452,-0.08841771,0.0071501206,-0.061694793,-0.017213184,0.0899025,0.018397667,0.06547251,-0.047612626,-0.06872202,-0.033138003,0.00011502819,-0.00024722764,0.050893027,-0.13743776,0.0122079775,0.029873397,0.020558212,0.025893869,0.04073908,0.01823572,-0.0024312367,-0.079121195,0.026580097,-0.02794211,0.013263762,-0.012727468,0.06616032,-0.014599851,-0.06412494,-0.09530239,0.018635117,0.09905278,-0.007858768,0.057101537,-0.05050058,-0.020601263,-0.011182512,0.0032450797,-0.015623166,-0.10140908,-0.063322015,0.019635003,0.027061729,0.03196892,0.0023370476,0.014171032,0.047181603,-0.024402993,0.0056949854,-0.012245876,0.018332046,-0.041571118,-0.028033385,0.08309696,0.023753291,0.051871922,0.061926335,-0.031463172,0.0020621007,0.04498029,-0.07605524,-0.054393817,-0.03510398,0.0027934946,-0.03555162,0.06362201,-0.027051806,0.021293988,-0.030506246,-0.0021485519,0.0073311576,0.016963694,-0.07011938,0.077332556,0.020284694,-0.055482373,-0.029833097,0.015149725,0.02593308,0.024970675,0.079019405,0.09183698,0.026657782,0.031538516,-0.110848084,2.3460981e-33,0.10568219,0.030936636,0.017396558,0.06440815,0.0408165,0.012213103,-0.07175398,0.005745582,0.036433477,-0.09884542,-0.074484654,-0.07486615,0.018500192,0.02106666,-0.059966937,-0.044515006,-0.030736422,-0.08076524,0.038074177,0.021354157,-0.0014007558,0.036690697,-0.04691065,0.02452415,-0.035013374,0.042746134,-0.016055567,0.019169437,0.10616464,-0.011376964,-0.019970316,-0.11026775,-0.11567892,-0.006332288,0.049486782,-0.032832984,-0.08017593,-0.040411368,-0.056202278,0.06837003,-0.038129658,0.012099775,-0.006199203,-0.016007457,0.09460552,-0.049712993,-0.04478362,0.1234881,0.04475916,0.039101787,-0.031001052,-0.05841514,0.15680625,-0.0182992,-0.04898399,0.009426973,-0.0009623932,-0.062209997,0.030725587,0.082700215,0.026274845,0.031427145,-0.016060479,0.06661774,0.051479865,0.023169095,-0.09964789,-0.032407943,0.06832046,0.044779293,-0.045892943,-0.044987023,0.033980574,0.019780884,0.013609805,-0.06659941,-0.11126237,0.062493242,-0.021588668,-0.008657474,0.036308847,-0.03345215,-0.014889641,0.004228751,-0.03648752,-0.0063154995,-0.028362783,-0.06519152,-0.024064641,0.031704985,0.025908258,-0.075054824,-0.03809918,-0.021818459,0.018982558,-3.6548507e-33,0.10971788,-0.09522985,0.053508136,-0.016771995,-0.01219602,0.07682287,0.025619946,0.02290316,0.02208138,-0.013649691,0.04562456,0.015571892,0.07946148,-0.035323072,-0.07204166,0.0072732125,0.04967329,0.11476359,-0.010371629,-0.022860946,-0.02835087,0.0038451385,-0.0034342401,0.033065006,0.053404965,-0.032518018,0.06737654,0.009073541,-0.037620556,0.052880418,0.019270565,0.0134008825,-0.05706202,-0.027647555,0.007491864,-0.00059147726,-0.03308572,0.004080871,0.032956142,0.02647646,-0.027406482,0.010267046,0.0042250077,0.054565962,0.039193526,0.108441934,-0.09354231,0.08239133,-0.0031906802,-0.05262589,0.056893308,0.021071486,0.009560794,-0.0052441126,0.06279556,-0.040674146,0.012627878,0.0058842227,0.054325923,0.05017664,-0.02826631,-0.049156465,-0.0235281,0.0114081465,0.008192741,0.03216498,-0.08504545,0.078945495,0.011726039,0.0016193363,0.07245539,-0.026910739,0.034258038,-0.01647612,-0.0655039,7.0919195e-05,-0.064382754,-0.080199696,0.02972633,-0.02286501,-0.01956433,-0.06423193,0.020685017,-0.033330686,-0.0313362,-0.07066007,0.04375196,0.10202232,0.015339076,0.016009482,-0.04846259,-0.021847967,-0.037751984,0.11908277,0.10551567,-5.166561e-08,0.07084575,-0.013189732,0.032568898,0.004119014,-0.020748092,0.018106628,-0.027892066,0.016475176,0.060328092,0.009877448,-0.037696682,0.017152686,-0.009916534,0.039600093,0.04360295,-0.008471092,0.035583433,0.060938496,-0.03089611,0.026871486,-0.061754193,-0.015716847,-0.101370044,0.010475898,0.045266937,-0.05840845,0.04688808,0.031123763,0.051526137,-0.08015002,0.0030462225,-0.0012777385,-0.024624432,-0.07379596,-0.12496059,0.015330207,-0.069477335,-0.029080804,0.014508819,-0.0011321664,0.04823451,-0.014525603,-0.08499545,-0.0073765223,0.04351033,0.034687866,0.00638753,0.033006683,-0.094681196,-0.00779249,0.054271508,0.052279074,0.060932297,-0.042670034,-0.10354232,0.01630199,-0.042745143,-0.07612586,-0.001697458,-0.05357443,-0.013064409,0.027839202,0.18125123,0.04715005 +2.5.1.46,"The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. This enzyme catalyses the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor. The reaction occurs in four steps: NAD+-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (Lys329 for the human enzyme; 1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d). Hence the overall reaction is transfer of a 4-aminobutyl group. For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor. Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29, deoxyhypusine monooxygenase.",384,0.99999994,-0.046739746,-0.035425942,-0.03056377,-0.07805531,0.1549971,0.07550147,-0.059749674,0.08066106,-0.0066988124,0.094948776,0.08118126,-0.046258297,-0.068182,0.02809654,-0.025259255,0.017686402,-0.10785506,-0.05347383,-0.050555225,-0.03267902,0.08285754,0.018996106,-0.058122844,-0.03178896,0.029860016,-0.030930432,-0.01231322,0.020834299,-0.0032212639,-0.06408798,0.018290216,-0.010905128,0.03369329,-0.060743682,-0.044583026,0.057163976,-0.065322734,-0.10344017,0.028467346,0.03892486,0.03091323,-0.010404628,-0.07756578,-0.0104593085,-0.03830367,-0.003498315,0.06450643,0.073511764,0.066892,0.038921755,0.010518332,-0.031206906,-0.00047825475,-0.020758187,-0.015734348,-0.062127784,0.027335048,0.013275653,0.039720315,0.024448449,-0.042422786,-0.0006939952,0.014076105,-0.073889785,0.081569724,-0.015733123,0.033275448,-0.07764602,0.019451892,0.012284828,-0.05984685,-0.06296778,0.008319279,0.066453114,0.016374348,0.06969388,-0.054812424,0.019765073,0.0013892971,0.009934959,-0.008568653,-0.025399828,-0.008028649,-0.012177195,0.010281485,0.045226958,-0.023673166,0.02105381,0.08477928,-0.027566625,0.02177654,-0.042359594,-0.026116526,0.031339634,-0.01306447,0.06028284,-0.0014248881,-0.0076535214,0.023470894,-0.050446842,-0.0059217573,0.06076392,-0.06363918,-0.041198146,-0.06317354,0.0250898,0.017005475,0.068975024,-0.041387618,-0.009818642,-0.055065468,-0.055177227,0.027964199,-0.002316931,-0.010016602,0.06092585,0.0072342493,-0.070325196,-0.0071226386,-0.09731941,0.07726498,0.002164051,0.09644141,0.07099023,-0.04614119,0.011548172,-0.12167475,7.274655e-33,0.084300295,0.057474405,0.017895887,0.06271148,-0.0005771302,0.027764253,-0.03766638,0.02195106,0.04223518,-0.057374842,-0.11328338,-0.0063490234,0.080160454,-0.06618338,-0.12599552,-0.074397944,-0.0059557264,-0.06876754,0.022690784,0.07963827,0.010893991,-0.015696563,-0.021702267,0.017949749,0.026971057,0.049334906,-0.04462668,0.03774355,0.07089396,-0.019573083,-0.051004507,-0.13550392,-0.09109101,-0.03438571,0.0897938,-0.037945766,0.019852718,-0.022180604,0.04652199,-0.0030394634,0.037064116,0.031235438,0.02816051,-0.041345567,0.060466733,-0.035190385,-0.076752014,0.06514335,0.020556007,0.03477351,0.0666781,-0.022707736,0.12787253,-0.11007905,-0.09655353,0.003188819,-0.034368377,-0.002140205,0.027908355,0.077759646,-0.008928863,0.051464953,-0.011166659,0.062333096,0.033457644,0.042446632,-0.09291466,-0.042283628,0.014722364,0.04385108,-0.045107555,-0.058938943,0.09123273,0.0013115115,0.053358186,-0.020320527,-0.07346323,0.07824184,-0.0032019378,-0.004622382,-0.013995433,0.040838268,-0.10899225,-0.014481923,-0.038524695,0.0071164174,0.012385187,-0.018813036,0.00047102847,-0.004222791,0.09863801,-0.07421216,0.10339068,-0.016962714,0.051964927,-7.792678e-33,0.105821684,-0.10645333,0.054432567,-0.053841885,-0.0041141887,0.08031951,0.0992292,-0.046691958,0.004040229,0.0066717044,0.070331186,0.0012713773,0.018053776,-0.035609275,-0.025164502,0.021151302,-0.00059154804,0.11668068,0.02230288,0.014993813,0.03434382,0.0033080007,0.046853006,-0.006436573,0.056267362,0.007675667,0.040117122,0.037459165,0.012948438,-0.034420505,-0.06799891,-0.031562,-0.0476483,-0.006344083,-0.024598688,0.013859916,-0.054433007,-0.03085583,0.061211154,-0.014649964,-0.0036771626,-0.00016085243,-0.004301055,0.044659205,-0.021231866,0.058170903,-0.09159636,0.05053739,-0.028979756,-0.004301986,0.030525403,0.014825048,-0.0837962,-0.022795284,0.0023719808,0.04564698,0.09604655,0.010850468,-0.0031879654,0.067106366,-0.009118345,-0.004727104,0.00085218257,0.034377888,0.031159554,-0.019443965,-0.057877894,0.07740581,0.055605393,-0.049604632,0.06593289,-0.019030683,0.083493434,0.010311564,0.032291245,-0.026517896,-0.038335342,-0.068087764,-0.003941646,-0.043193657,-0.056992836,-0.043914575,-0.07376316,0.0049993424,-0.023639817,-0.053822447,0.034975637,0.11438089,0.034624793,-0.008303432,-0.035196863,-0.03183879,-0.0018823651,0.121746145,0.12341024,-5.149315e-08,0.0039107124,-0.01853396,0.04935335,-0.035768,0.013841402,0.007189272,-0.03074393,-0.03576757,0.054331332,-0.06519221,0.016510595,0.067987,0.008461422,0.02589228,-0.0023727217,0.0031455304,-0.0046083247,0.057224087,-0.012183116,0.034444626,-0.04168115,-0.036262468,-0.089109235,0.012064051,0.025085438,-0.07617341,0.015931323,0.033814237,0.036575597,-0.09603386,-0.00050932687,-0.0049125804,-0.019174265,-0.068247795,-0.09215118,0.041262522,-0.039262626,0.001706135,-0.0328991,0.030548861,0.010225398,-0.025643874,-0.09069521,-0.04550321,0.0041852808,0.032840006,0.012394045,0.008401768,-0.04811316,0.004357861,-0.054242756,-0.013422243,0.028803783,-0.055540357,-0.063337564,-0.030509323,-0.052260067,-0.041889913,0.08394893,-0.056414526,-0.010015129,0.060325474,0.13626504,0.008885946 +2.5.1.47,"A pyridoxal-phosphate protein. Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors. Not identical with EC 2.5.1.51 (beta-pyrazolylalanine synthase), EC 2.5.1.52 (L-mimosine synthase) and EC 2.5.1.53 (uracilylalanine synthase).",384,0.99999994,-0.067899376,-0.102747224,-0.05484158,-0.02214465,0.07184665,-0.018173395,0.030035244,-0.017494155,0.032158967,0.009131258,0.05242261,0.028188543,-0.09134052,0.084754385,-0.02067553,0.061807405,-0.0877253,0.043387614,0.0329877,-0.017550927,0.013439293,0.019674903,-0.013175255,0.02249104,-0.025651615,0.048503567,-0.009230317,0.08590398,0.0010947408,-0.13137475,-0.09937068,-0.04461391,0.022758232,-0.04133671,-0.033256873,0.06007603,-0.1236105,-0.07531611,-0.032661434,-0.018794311,0.064172484,-0.09689261,-0.017730951,-0.0127351275,-0.044275496,-0.06593135,0.04564681,0.026206816,0.02938528,-0.046328288,-0.06400508,-0.027805217,-0.019215908,0.017521335,-0.058028266,0.010065847,-0.071984686,0.04969275,0.029522443,-0.029267034,0.002675145,0.04154674,0.007455065,-0.0099236285,-0.037332173,0.005306062,0.004621621,-0.0497496,-0.0073734657,-0.0062374277,-0.04563356,-0.065267645,0.03631228,0.05676031,0.037700567,0.109848104,-0.03895961,0.00014655213,-0.051469233,0.02637475,0.0027234636,-0.04548721,-0.06857712,-0.0026295728,0.05524324,0.0012320349,-0.016925955,0.1038793,-0.022307964,-0.014703404,0.07999914,0.040706344,0.04620062,-0.006677491,0.02047065,0.010833554,0.07671633,0.056373306,0.014869772,-0.035823196,-0.018600298,0.008408637,-0.051408082,-0.02915489,-0.038000107,0.012035973,0.016635526,-0.0005870764,-0.014768141,-0.026646402,-0.09086695,-0.06486828,0.027683452,0.023945995,-0.022678846,0.032119777,-0.002818254,-0.05105594,-0.0036969627,0.025275836,0.016024852,-0.023812916,0.03242327,0.053115953,-0.048699725,0.033023015,-0.14534369,4.1893256e-33,0.049633276,0.1122179,0.050835546,0.00070626196,0.013901034,0.028872242,-0.08946507,0.014867559,-0.006633022,-0.08465418,-0.05590145,0.0012226034,0.08872039,0.029157912,-0.03578785,-0.03670319,-0.0050624823,0.0844653,0.12826933,-0.039462317,0.029305885,0.048146,-0.10679161,0.012753802,-0.012028726,0.07489281,-0.01798978,0.035725076,0.047260035,0.0036320006,-0.026549917,-0.09321774,-0.03468938,0.0030060757,0.050434794,-0.027321197,-0.017284524,-0.027706508,-0.028156077,-0.056813408,-0.04008603,-0.030694587,-0.06203167,0.041012652,0.034868263,-0.058403287,-0.076060735,0.023835992,0.005421397,-0.01943038,0.015880356,-0.0791309,0.0024287617,-0.04341948,-0.035761338,-0.022202397,-0.052570704,-0.015175983,0.0035630215,0.039871052,0.020589324,0.0643574,-0.06442908,-0.050506346,-0.068891466,0.027121188,-0.03798334,-0.0916555,-0.0020275349,0.044697545,0.010112331,-0.029132275,0.048359003,0.06441165,0.049485274,-0.024912024,-0.093710765,-0.025504293,0.012532555,0.07059017,-0.04447118,-0.037762817,-0.051864877,0.028840523,-0.0548897,-0.052288752,0.0020801562,-0.01676611,0.0717358,0.056614876,0.03580021,-0.081408925,-0.06559822,0.028505055,0.0412065,-4.7845015e-33,0.11231901,-0.03940956,0.08875291,-0.018843401,0.019598838,0.025524445,0.08422132,-0.07597923,0.12057778,-0.00411349,0.08796625,-0.041023348,0.04277156,-0.08932367,-0.014526299,-0.030714365,0.0028302886,0.010648115,0.037776154,0.06638539,-0.03995328,-0.02500921,0.0050747385,0.057061046,0.0015095181,0.08443272,0.00043929403,0.039819144,0.026705626,0.06528511,-0.05888205,0.025824284,-0.03275789,-0.09502712,0.0136641655,0.019132514,-0.10166501,0.021966958,0.0026407263,-0.019703021,0.049006995,0.030547341,0.026366295,0.07575717,0.06581111,0.085786484,0.07327639,0.027171632,-0.03082835,-0.11911194,0.027482484,0.093309276,-0.0043988163,0.03206839,0.070255965,0.07276503,0.0030284903,0.026281223,0.03414114,0.012828304,-0.00631072,-0.09357748,0.04123597,0.0037555087,0.002193964,0.011050341,-0.016859934,0.05694499,0.034520067,0.042948686,0.108125776,-0.051134214,0.03215774,0.09763881,0.00014529543,0.015477315,-0.029487517,-0.029067365,0.012602152,-0.047375735,0.0011938706,0.03092781,-0.013544638,-0.06572432,0.005842868,-0.017682096,0.06314349,0.05098417,-0.038636193,0.03845162,0.014726579,0.00840931,-0.043388743,0.12317741,0.10826397,-4.9478572e-08,0.032339223,-0.06597651,0.029214557,-0.06427786,0.0047656307,0.014079826,0.036979873,0.024499824,0.097871706,0.021446051,-0.021803152,0.03745297,0.06855456,-0.004092725,0.04347673,0.045471873,-0.019967861,0.03501474,0.007388773,-0.01184007,-0.032036226,0.025279868,-0.12861927,-0.042014882,-0.015046126,-0.038331542,0.011254037,-0.018707167,-0.04745756,-0.0022896403,0.058585152,-0.01310855,0.01769806,-0.044322204,0.022199355,0.046795797,-0.024853442,-0.05173352,-0.042811517,-0.04415348,-0.027163783,-0.05258418,-0.06748723,-0.021600738,0.025229774,0.03742393,0.0043605766,-0.0020488286,-0.05565874,-0.060789555,0.081545286,-0.0494836,-0.004710955,-0.14748962,-0.058474317,0.03288964,0.009391851,-0.030194081,-0.04432102,-0.06829826,-0.00073069823,-0.020426666,0.19037803,-0.008023736 +2.5.1.48,"A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.",384,1.0,-0.014052726,-0.025638966,-0.061968774,0.0015459664,0.061802898,0.096743114,-0.0066242246,0.02174617,0.029481735,0.045668624,-0.0049499073,0.010887009,-0.063962266,0.048149392,-0.007743091,0.09037216,-0.061060723,0.043674782,0.048520852,-0.05510242,0.036137324,0.01171814,-0.04263568,-0.004861505,-0.009379598,0.11971688,0.038541317,0.049623266,-0.052067265,-0.055045106,-0.041162785,-0.07312947,0.0060715885,-0.05258325,0.013529296,0.12881307,-0.10759675,-0.011836019,-0.0073836907,-0.059774637,0.05230355,-0.059032228,-0.050287325,0.013486588,-0.03264127,0.014902446,0.019382432,0.04647196,0.034300838,-0.071194254,-0.0940646,-0.03680094,-0.030948121,0.05473891,0.024577916,0.052289158,-0.07071995,0.04350867,0.013682971,-0.0972419,-0.025127467,0.003976562,-0.003192752,-0.036446057,0.086419284,-0.025809936,-0.031384323,-0.04152829,0.032891113,0.00931184,-0.068610966,-0.019109203,0.053586364,-0.01726914,-0.024044704,0.05857309,-0.07260587,-0.0132729,0.039539337,-0.037948295,0.03902273,0.02003649,0.024876177,0.060323764,0.0783544,0.012505377,-0.007772534,-0.01591507,0.021368118,-0.03630081,-0.016802857,0.010488576,0.06758615,-0.00721639,-0.090073384,0.021666145,0.022677274,0.036797013,0.043921646,-0.014214991,-0.00931161,0.04093806,-0.093063936,-0.11770654,-0.086139545,0.04933897,-0.025128737,0.066058084,0.024049807,0.045098167,-0.05131926,0.014966825,-0.011031874,-0.004593524,-0.012986713,0.07335071,0.09651619,-0.020488756,-0.13974495,0.0011488552,0.015517862,-0.02633915,0.025821522,0.059249297,-0.053906612,-0.0041497843,-0.109672956,3.4491326e-33,0.09122899,0.093065836,0.027734475,0.028476877,0.026468022,-0.008307346,-0.052243,0.007851292,0.044124223,-0.029101992,-0.04553836,-0.048143532,0.04456134,-0.027409146,-0.06644203,-0.029170671,-0.0876088,0.044855718,0.121691145,0.013004042,-0.035240486,0.044696502,-0.028108846,0.049906705,0.0008830175,0.05011941,-0.003836875,0.005913051,0.021752484,-0.007011761,0.026119377,-0.04832103,-0.11433634,0.012994872,0.019586366,-0.06759034,-0.13825347,-0.039979164,-0.038342126,0.02271902,-0.03908503,-0.030480672,-0.040884577,-0.038400963,0.036520485,-0.09510552,0.008072455,0.06400185,0.027678555,0.017018244,0.023421027,-0.08886321,0.072748214,-0.006997149,-0.08516845,-0.032029867,0.012791437,-0.053101525,0.02426414,0.061507173,0.03212228,0.03293816,-0.050175544,0.009654192,-0.056083225,-0.032888792,-0.037384346,-0.057514578,0.01971854,0.07158695,0.04583111,0.0047641206,0.04124391,0.066163056,-0.054687187,-0.029431205,-0.063204534,0.01959392,0.041513857,0.062745064,0.03669716,-0.077413686,-0.021633336,-0.015447333,-0.0052888435,-0.02682739,-0.008604806,-0.07789878,-0.02081012,0.048479434,0.014175492,-0.088361725,-0.044051453,0.018978577,0.042308275,-4.0931514e-33,0.07967751,-0.069240354,0.019497488,-0.07800183,-0.05831486,0.015843261,0.036665983,-0.075290225,0.03749912,-0.010632469,0.09518477,-0.07906222,0.052842155,-0.00582992,0.014619972,0.00056279363,0.013819597,0.015975581,0.030190056,-0.011263319,0.03869899,0.095178075,-0.0724244,0.06631468,0.09072658,0.056622338,0.038855974,0.056428526,0.048029263,0.09590318,0.025520682,0.002213957,-0.010402343,-0.06487573,0.009714701,0.023839688,-0.04683618,0.022408143,0.036920276,0.0058928784,0.014970948,-0.0022199764,0.08688138,0.0942981,0.0480906,0.08133389,-0.06446773,-0.0016721409,-0.0019548945,-0.082470246,0.08276134,-0.01097303,-0.054900702,-0.023461124,-0.00032992987,0.04681027,-0.06516623,-0.0308599,0.036772985,-0.055501096,-0.0118478155,-0.102425806,0.014340345,0.016399372,-0.0013064417,0.05539387,-0.023942944,-0.01004205,0.055803545,0.04172208,0.04189391,-0.022811154,0.052569997,0.06351148,-0.006340702,-0.037915036,-0.047151264,0.073411055,0.048992574,-0.011435407,-0.024190776,0.0096672205,0.013236131,-0.09376051,0.009188859,-0.0125046605,0.017574394,0.06741063,-0.05892404,0.050407514,-0.034299612,0.07375195,-0.0031427336,0.08741192,0.08090224,-4.336161e-08,0.03086031,-0.11281202,0.04262293,-0.012780779,-0.013110297,-0.006440257,0.049001943,0.014244382,0.06149981,-0.016863903,-0.045482736,0.07825266,0.06817717,-0.007855555,0.04371577,0.026341954,-0.014347483,0.0089834975,-0.045665152,-0.07688566,-0.06938048,-0.0003269536,-0.084700026,0.055264764,0.058932774,-0.0514014,0.02542415,-0.06837546,-0.047173828,-0.031872585,0.07267036,-0.0036311597,0.014260714,-0.05753562,0.0052260314,0.050282802,-0.0074014203,-0.04779119,-0.0012383708,-0.08001794,-0.048515707,0.06895152,-0.08837263,0.028067118,0.037487235,0.0036536306,-0.020362133,-0.0031272972,-0.075629845,-0.028656308,0.06450323,-0.001229041,-0.039380107,-0.089470364,-0.099050865,0.033191763,0.062702574,-0.011972631,-0.010349414,-0.046101958,0.016970577,-0.038289785,0.15449691,-0.04348311 +2.5.1.49,"Also reacts with other thiols and H2S, producing homocysteine or thioethers. The name methionine synthase is more commonly applied to EC 2.1.1.13, methionine synthase. The enzyme from baker's yeast also catalyses the reaction of EC 2.5.1.47 cysteine synthase, but more slowly.",384,1.0,-0.042658214,-0.025155991,-0.035260472,0.026888113,0.06939758,0.02472001,-0.090504624,0.07696545,0.052817274,-0.00954136,0.014606774,-0.1241756,-0.01495262,-0.0463599,-0.01665498,-0.003090959,-0.030794077,0.051313456,0.038021788,-0.07930787,-0.005306298,0.057559785,-0.019861838,0.011606217,-0.011593692,0.0035940357,0.017961994,0.020728817,-0.041247062,-0.06400769,-0.034566253,-0.056962866,0.054958235,-0.027376063,-0.0076417425,0.08668753,-0.05249167,-0.022812549,0.009518039,-0.0112685235,0.032016072,-0.033292074,0.01081872,-0.044774935,0.014737364,0.00084337144,0.043894455,0.037114277,-0.019771386,-0.050818544,-0.045126174,-0.058830693,0.006786141,0.026931196,0.0047315783,0.017409911,-0.062065274,0.06080275,0.031626336,-0.024293974,-0.0028600488,0.024145512,-0.012598114,-0.061314702,0.036013424,-0.033235885,0.041950624,-0.04353405,0.044520624,-0.014823159,-0.03964208,-0.02118998,-0.0068096276,0.017339475,0.02090513,0.042465292,-0.071334995,-0.06489656,0.042305622,-0.03668996,0.026623148,-0.021042734,-0.050067563,-0.03335265,0.032230254,0.014541782,0.013770888,0.024304546,0.03336297,-0.029236557,-0.008345003,-0.020939637,-0.0042184116,-0.044900823,-0.106872655,0.031044805,0.028418068,0.19810487,0.06600442,-0.030508015,-0.0059405304,0.07247128,-0.092307456,-0.060011502,-0.035764027,-0.009213453,0.06980284,0.07301292,0.011251779,-0.01985632,0.044043623,-0.073762566,0.052428707,-0.02855104,-0.025773609,0.10336528,0.057593744,-0.030290775,-0.023214024,0.022819232,0.05678658,-0.007810302,0.046463653,0.05184096,-0.028589347,0.01931192,-0.121688895,2.406073e-33,0.045071926,0.07883672,0.018384673,0.009472566,0.063125506,-0.015482932,-0.08733668,0.080725424,0.0047654705,-0.08865542,-0.022618316,-0.017575925,0.023817662,-0.0051684366,-0.06441034,-0.107681274,-0.013975714,-0.013249558,0.03956704,-0.011480138,-0.03762974,-0.03000438,-0.037964486,0.07354295,0.008448833,-0.016444491,0.018070161,0.014127635,0.07772775,0.005452164,-0.07311795,-0.040540077,-0.0022582775,0.029973682,0.0007387598,0.004,-0.04002547,0.013277614,0.0028167348,0.0077051967,0.016845249,0.021824809,0.0017619242,-0.062789924,0.05048366,-0.0136263175,-0.08027794,0.07632171,0.06602446,-0.009338114,0.037216213,-0.0761661,0.13211225,-0.0130838,-0.0015593304,0.0041029444,-0.015749518,-0.009461923,0.044416398,0.14248359,-0.07360065,0.13859816,-0.029369052,0.06367706,-0.08040295,0.021704368,-0.03797431,-0.031652123,-0.034559987,0.09380047,0.02043728,0.033829886,0.058146693,0.031604633,0.052184112,-0.019946458,-0.13265824,-0.00067636423,0.0330268,-0.004297606,0.016840765,-0.0131611265,-0.029164024,0.011900483,-0.05499994,-0.022445193,-0.044556256,0.019517908,-0.029683437,0.06884099,0.0050778133,-0.06091034,0.0044282996,0.025206547,0.028452145,-2.4640329e-33,0.021932939,-0.02656803,0.029206565,-0.075953476,-0.03599518,0.0573745,0.003284666,-0.089414224,0.08316745,-0.06390886,0.11246082,-0.097968094,0.040594194,-0.037075363,0.002375362,-0.051144686,-0.017878786,0.061552066,0.005094392,0.004130001,0.028065111,-0.01141301,-0.058017626,0.007647425,0.112940736,0.0075604995,0.016744833,0.14923131,0.06186208,0.08942496,-0.074404985,-0.021960992,-0.03356356,-0.017057462,-0.031113634,0.08685909,-0.00249043,0.00821032,0.0491195,-0.01118281,0.00537195,0.0009774924,0.045059945,0.12833546,0.04892305,0.10873457,-0.017991265,0.041877788,-0.005056313,-0.10144873,0.029121643,-0.049067643,-0.088892266,-0.01801704,-0.04277069,0.0777878,-0.04395194,0.008258359,-0.006690205,-0.056619845,-0.02929712,-0.08577386,0.029340515,-0.026123703,-0.019708745,-0.024050685,-0.091008954,0.02358948,0.034202784,0.03583648,0.097192936,-0.016010527,0.010477791,0.04513695,-0.036859214,-0.05794654,-0.03347044,0.002829025,0.033181567,-0.042728417,-0.002415618,0.0007611204,0.028316433,-0.025321748,-0.0083948895,-0.0046729944,0.030705342,0.06871466,-0.051871944,0.08993644,-0.08419083,0.050460424,-0.009447085,0.078531876,0.016064543,-3.5078642e-08,0.06149853,-0.12770876,0.06520443,-0.034035534,0.054157715,0.048487544,0.03335116,0.029088521,0.04234527,-0.003848834,-0.08916594,0.04945015,0.0606637,-0.0017783245,0.035192735,0.035536468,0.015094292,0.052453525,-0.033675462,-0.012632914,-0.037902426,-0.009112625,-0.05670919,-0.013081283,-0.034306917,-0.09020107,0.035004023,-0.024262644,-0.06841525,-0.07520599,0.017710691,-0.0035500617,-0.0057344246,-0.020217266,-0.01312866,0.011317357,-0.07584288,-0.055308823,-0.010710131,-0.06614061,-0.022154551,0.010020443,-0.10800239,0.046160225,0.04311233,-0.053878836,0.048664607,0.009121837,-0.01597384,-0.007317126,0.025666887,-0.015330678,0.07364401,-0.081619516,-0.030682754,-0.0036289927,0.0043936106,-0.040409572,-0.0025623452,-0.026883531,0.03948572,0.02712838,0.20966266,0.0028845468 +2.5.1.50,The enzyme acts not only on zeatin but also on other N6-substituted adenines. The reaction destroys their cytokinin activity and forms the corresponding 3-(adenin-9-yl)-L-alanine.,384,1.0,-0.008531284,-0.0069477777,-0.014654596,-0.048228476,0.044181786,0.034433484,0.011046427,-0.014051521,0.05171692,0.045232475,-0.031871524,0.069970034,-0.05411761,0.0005189956,0.002550865,0.07811383,-0.056016423,-0.020467604,-0.06680055,-0.11053255,0.014052105,0.062411547,0.083496995,-0.03577338,0.018098557,-0.005338639,0.046712425,0.096955016,0.05657067,-0.028475324,-0.0090250885,-0.0026783901,-0.035505004,0.010376052,-0.01824639,0.0524259,-0.050579958,-0.054572985,-0.034540612,0.02385665,0.09910507,0.00897757,-0.08644729,0.005259582,-0.051406633,-0.025884723,-0.044995166,-0.016199758,0.0118567115,0.08074148,-0.01758228,-0.10259968,0.011594754,-0.005067069,0.008657955,0.0096734045,-0.11706944,-0.03270132,0.059139866,0.05697344,0.007924959,-0.016286718,0.032774117,-0.013281274,0.059299067,-0.03650343,0.0009992076,-0.036804322,-0.047487002,-0.010357041,-0.023875037,-0.055337764,-0.0027319253,-0.051443174,-0.06837887,-0.027858024,-0.012796467,-0.02261917,-0.033190966,0.020067096,0.06005598,-0.0052147345,0.11309536,0.05959917,0.038568318,-0.061775666,0.00056078815,0.056048844,0.0373077,0.030397672,-0.0031716987,-0.04261621,0.06576295,-0.018233206,0.012849108,-0.012035905,0.0041979277,-0.03317953,-0.010903507,0.033925086,0.039431624,0.033051327,-0.09341205,0.009929779,-0.026874773,0.094484955,-0.042785496,0.104324155,-0.056843698,0.045987654,-0.02235065,0.007474966,-0.024672026,-0.0039361212,-0.08486047,0.0899549,0.033369806,-0.014933843,-0.060507447,0.06511626,0.032671075,0.028290447,0.085981615,0.08378503,-0.04197819,0.09084346,-0.093337245,2.3671093e-34,0.015302065,0.028942306,-0.014247229,-0.0056817713,0.017588884,0.0017609838,-0.04590975,0.08065791,-0.04286673,-0.039335873,-0.022657786,-0.024179226,0.12638447,-0.04603746,-0.027006948,0.039445844,-0.016558867,-0.024436358,-0.012511195,-0.01746782,0.0004628178,-0.03390387,-0.060129553,0.019538926,-0.07487893,0.03851981,-0.02810216,0.055938482,0.053598475,-0.032675922,-0.020412765,-0.056396,-0.08863324,0.04698081,0.013459068,0.06721958,-0.050555468,-0.019885235,0.0484848,0.035832025,-0.031073399,0.0074794753,0.00071331585,-0.056269415,0.018719582,-0.023283457,0.02626086,0.050513946,0.0536966,0.03563273,0.10641618,-0.07298899,0.049167477,-0.024784865,-0.043216147,0.07443857,-0.030441554,0.02954265,-0.007984075,0.037597194,0.033635896,-0.084316924,0.019637883,0.07423406,-0.06390129,0.07849588,-0.10374155,-0.13486962,-0.016493987,0.069364585,-0.032880686,0.0023656948,0.14093983,0.06123183,0.005875089,0.042392373,-0.024912266,-0.015216681,-0.026855057,0.07103827,0.051542208,-0.009486107,-0.046168536,0.0025542725,-0.06683892,-0.09392573,-0.02173551,-0.10153237,0.040546093,-0.02901313,0.1435626,-0.08356717,-0.09277516,0.00018501951,-0.010976503,-1.2358153e-33,0.035120472,0.0132917715,0.021541448,-0.04994733,-0.05103241,0.00932632,0.024525393,-0.09466858,-0.032503616,-0.021398658,0.07777802,-0.018209832,-0.02787388,-0.035506263,-0.0053565856,-0.029494062,0.0047278884,-0.0050882525,0.0088461,-0.039008386,-0.02007842,0.032416034,0.01671639,-0.0020265582,-0.014109233,-0.028009787,0.030889753,0.00678633,0.12795234,0.039050627,-0.111409925,-0.065245114,-0.057611734,0.030328434,0.054275256,0.081371546,-0.00755161,0.03005019,-0.018698277,-0.0046973065,-0.0048176954,-0.007252919,0.018212307,0.100003354,-0.01449115,0.119276434,-0.01828222,0.012121843,-0.03776977,-0.07174334,0.03512524,-0.010226973,-0.033140715,0.06562208,0.031163327,0.0907553,0.066012435,-0.06185733,-0.07651208,0.022734214,0.04502301,0.009536117,0.02185878,-0.030698018,0.008740674,-0.0009294047,0.0013588063,0.09283512,0.03563282,0.0055394727,0.0603356,0.007352956,0.014471245,-0.0058903564,-0.005680918,0.035029404,-0.030430218,-0.10160666,-0.07159891,-0.082996994,-0.019704562,0.018788349,-0.018854473,-0.033757243,-0.039301194,0.012848674,0.049902514,0.14251606,-0.020768661,0.023849543,0.029070051,-0.04250815,-0.034536637,0.072375394,-0.0016298132,-3.2038752e-08,-0.0020754347,-0.055889994,0.022771873,-0.10016168,0.027847586,0.041505795,0.027056284,0.049557943,0.047275845,0.024902735,-0.06896182,0.07068608,-0.03623417,0.013704609,-0.0018998461,0.046395507,-0.022413932,-0.006962759,-0.0142954625,-0.058554485,-0.14411467,0.049766988,-0.048648622,-0.0017135352,-0.04877174,-0.017462602,-0.018844653,0.13029869,0.008097326,-0.04078168,-0.006276528,0.048514422,0.06291729,-0.08162686,-0.13747634,-0.018144134,0.030084455,0.0033177477,-0.04110098,0.008698272,0.03973284,-0.016349882,-0.05753972,0.00867007,-0.056463085,0.027185498,-0.013862985,-0.0214323,0.00441288,0.02284847,0.09656897,0.013892272,-0.048231367,0.012481428,-0.042464834,-0.044264775,-0.06359178,-0.068659306,0.06707707,-0.028445508,-0.025210591,0.011325209,0.11944545,-0.05380445 +2.5.1.51,The enzyme is highly specific for acetylserine and pyrazole. Not identical with EC 2.5.1.52 L-mimosine synthase.,384,1.0,-0.04351537,-0.11160003,-0.059493683,-0.02259191,0.050341766,-0.032005187,-0.050239917,0.03700958,0.023875466,0.005330781,0.052054815,-0.013258793,-0.113753974,0.06490979,-0.05682776,0.07425032,-0.044097103,-0.062018644,0.03034781,-0.019735072,0.07660133,-0.054618493,0.009567421,-0.00049456063,0.0068872226,0.013934739,-0.006336106,0.13150185,-0.08411002,-0.115791254,-0.052403804,-0.02834733,0.06139682,-0.06835892,-0.0048798737,0.012002459,-0.053397004,-0.082882695,0.03694065,-0.010461566,0.022472847,-0.06930568,-0.026170595,0.013546757,-0.015511595,-0.09566368,0.02342598,-0.009688378,0.017983703,0.016197272,-0.04263121,-0.09434503,-0.05743624,-0.018150909,-0.015119751,0.035462435,-0.06408561,0.031714268,-0.012781601,-0.038709555,0.0020940616,0.08260023,-0.048754323,0.01416481,-0.067777015,0.011492655,0.04958759,-0.08317401,0.0029638687,0.01624814,-0.072090276,-0.1263352,-0.0052407607,0.06981711,0.051227514,0.063827634,0.03588791,-0.00882206,-0.007537447,0.0052249846,0.018536415,-0.049339168,-0.08597191,-0.045000724,0.014117325,0.028738456,0.029433768,0.038866397,0.071797,-0.08268465,0.04509374,-0.0191485,-0.009243364,0.012084421,-0.014713203,0.053563986,0.01811687,0.12759341,-0.02021725,-0.040229563,0.006440124,0.014946415,-0.046024304,0.027099067,-0.031562384,0.0029484516,0.048937798,0.04239437,-0.013570983,-0.08183733,-0.07738844,-0.033904113,-0.004092654,0.046268694,0.0056228954,0.057696022,-0.019308662,0.011645322,0.042015065,0.068351015,0.10179572,-0.012180945,0.027691448,0.018051913,-0.017041357,0.077565566,-0.12771237,1.3018476e-33,0.038622737,0.055050634,0.108000614,0.0010441082,0.02571953,0.008496465,-0.07411773,-0.0005360127,-0.016487438,-0.05597156,-0.069374174,-0.03208416,0.02930682,-0.005322326,-0.041854486,0.03395282,0.0026005572,0.005108906,0.06800598,0.06723597,0.018177478,0.055394553,-0.109655306,-0.01852385,0.01434555,0.05139984,-0.014330535,0.035298795,0.06818314,0.040146332,-0.046208676,-0.089027114,-0.0016711676,-0.009254175,0.0067898347,0.010637483,-0.01623158,-0.04407848,0.024823055,-0.012762203,0.008478678,0.032568317,0.032871563,0.036303677,0.0056179073,-0.04099034,-0.10773475,0.07107457,0.07505639,-0.012485095,0.037112027,-0.054197583,0.06746419,0.039612796,0.047642652,0.06694615,-0.09983001,0.041220725,0.041957416,0.030613156,0.013696691,0.06227101,-0.0049147108,0.012573985,-0.0016123133,0.067974694,-0.0497361,-0.048282802,-0.029464493,0.102975026,-0.06230434,0.009450514,0.06828994,0.070650406,0.087819934,-0.06480191,0.0094135655,-0.016063498,0.030286208,-0.019908177,-0.053835377,-0.023794722,-0.0037159882,0.023902124,-0.06604779,-0.050552092,-0.006901099,0.06723792,0.02751389,0.06480347,0.0427905,-0.04306017,-0.05539494,0.025859594,-0.003362631,-1.60177e-33,0.044692058,-0.03161791,0.053172484,-0.038848393,-0.04604882,0.070251085,0.062368598,-0.047850598,0.0512639,0.020386694,0.087519914,-0.0016864232,-0.0056197937,-0.11090157,0.0042548487,-0.014817005,-0.0194129,-0.052195486,0.053362865,0.046157382,-0.0070182662,0.039277513,0.04463768,0.015932957,0.02616542,-0.005440611,0.027492868,0.0631099,0.00365376,0.0018132306,-0.047393937,-0.01834623,-0.019136792,-0.12694015,-0.024666792,0.013235469,-0.04049764,-0.027511543,-0.017794931,-0.021438997,-0.009298567,0.04571597,-0.016477188,0.039480925,0.017714322,0.122856244,0.015572404,0.016396636,-0.0061863135,-0.11535642,-0.012752523,0.011289305,-0.03218235,0.02598407,0.039241947,0.03534021,0.041029673,0.044827852,0.027874196,-0.0025470357,-0.036288828,-0.018165113,-0.012691374,-0.018719526,0.10541978,0.057809044,-0.0027404577,0.084003925,-0.0022719707,0.057368383,0.069394566,-0.046673782,-0.02059704,0.09836891,-0.021000257,-0.021339914,-0.07655679,-0.042963997,0.0131525975,-0.029156366,0.06355774,0.010438229,0.00021898914,-0.03516776,-0.07082179,-0.06190891,0.045221772,0.10622583,0.012740982,0.06700293,-0.0010228866,-0.005273036,-0.08781484,0.031067017,0.08021104,-2.5862605e-08,0.04727112,-0.029906139,0.02288612,-0.07515828,-0.0033730112,0.0046614455,-0.025750654,0.034196958,0.120537646,0.041767053,-0.08050349,0.08498834,0.09286796,0.05680156,-0.03581043,0.02871818,0.022669125,0.04166185,-0.0017767395,0.0099316845,-0.05132704,0.046101313,-0.13218586,-0.06750099,-0.003863058,-0.04940389,0.028086975,0.08469184,-0.06556291,-0.024686543,-0.00841581,-0.0024260983,0.04601482,-2.834048e-05,-0.104985416,0.010685378,-0.06469178,-0.0332633,-0.0063896603,0.016918961,-0.006570283,-0.106628336,0.011099602,-0.012740635,0.034174807,-0.015512438,0.04224985,-0.0682786,0.019191945,-0.02247831,0.029170915,-0.03836584,-0.004825412,-0.14032863,-0.06210358,-0.023404574,0.00014974405,-0.006893688,0.017771149,-0.08783456,-0.01405159,-0.026393926,0.14889888,0.028823849 +2.5.1.52,"Brings about the biosynthesis of L-mimosine in plants of the Mimosa and Leucaena genera. Not identical with EC 2.5.1.51, beta-pyrazolylalanine synthase.",384,1.0,-0.06692571,-0.07474096,-0.049691822,-0.004556146,0.074704155,0.028118316,-0.05427293,0.038144667,0.027449539,0.016000884,0.055125386,-0.005225242,-0.09593112,-0.007703724,-0.07981528,0.0897004,-0.06100448,0.020053767,-0.032520745,-0.013524171,0.10583127,-0.0082489,-0.009995668,0.06802989,0.040062383,0.034352142,-0.031321686,0.06608523,0.0033697467,-0.06832563,-0.07968817,0.010674903,0.095795006,-0.11145599,-0.013765988,0.009031283,-0.00891234,-0.100584574,0.0824002,-0.0024784412,-0.04827796,-0.053195395,0.015524617,-0.039687175,-0.04606299,-0.07121378,0.034687724,0.0053126183,-0.014193209,-0.0084244395,-0.0475615,-0.05822058,-0.07656022,-0.013425259,-0.031392597,-0.023912814,-0.06801617,0.058581445,0.03841468,0.05201871,0.002132474,0.088433616,-0.03825602,0.025002895,-0.07437895,-0.014872917,0.0014530134,-0.023754947,0.026950238,-0.014246845,-0.03431087,-0.10693975,0.0037679102,0.020283416,0.03718815,0.123446435,0.06987541,0.03472804,-0.0406738,-0.02016737,0.015616364,-0.04371726,-0.059301063,-0.060258076,-0.027531214,-0.0050914763,-0.026715266,0.12207008,0.10389514,-0.032627933,0.06771067,0.049638104,-0.04930921,0.02369482,0.022516942,0.10825241,0.04158019,0.063269414,-0.006340383,-0.0326974,0.008709371,0.002334119,-0.029232929,-0.021207174,0.008916423,-0.005041389,0.043349538,0.04124615,-0.022468297,-0.088956624,-0.0031721925,-0.02224294,-0.046875555,0.08257245,-0.0629057,0.010755621,0.010040991,0.0013428443,-0.03374825,0.017250359,0.100380875,-0.046970308,0.002709197,0.014386381,-0.068118855,0.046944547,-0.11545997,1.2375631e-33,0.097207636,0.046324864,0.01754049,0.00723334,0.014051074,-0.01566421,-0.03294924,-0.023474006,-0.037539616,-0.054133605,-0.07515085,-0.028701985,-0.009619342,0.00066860334,-0.04508686,0.039832547,0.03252536,-0.0442531,0.10116864,0.039997336,0.016658574,0.039874107,-0.08698529,-0.058633823,0.0044627166,0.08126735,0.04931601,-0.03033386,0.018959703,0.014129017,-0.064847,-0.13241759,0.032313753,0.033068035,0.0500577,-0.014291395,-0.03770312,-0.06571035,0.009672245,-0.011571151,0.024004122,0.078642845,0.0051923604,0.057189684,0.050487235,0.036149785,-0.04845757,0.022308372,0.044056322,0.012457609,0.02433813,-0.003268156,0.052656937,0.013328524,0.00028129527,0.030995904,-0.07952048,0.05177604,0.046963654,0.041165195,-0.01915314,0.07667405,0.0071282294,0.019840632,0.051365156,0.003057362,-0.10699621,-0.0067221,-0.011058529,0.026927877,-0.04792219,-0.10244207,0.0175262,0.024618877,0.066308655,-0.05402303,-0.009776062,-0.027880847,-0.025657853,0.004634893,0.03883434,0.039799992,-0.037704438,-0.0015868177,-0.0207511,0.008636863,-0.04522863,0.027957458,0.031012427,0.054376267,0.04632583,-0.049360886,-0.0031363484,0.024333453,-0.005609231,-1.7515468e-33,0.050028753,-0.01951527,0.062104702,-0.015561503,-0.07525227,0.02197655,0.0067009036,-0.067558534,0.025008678,0.01581716,0.0025857145,-0.007973773,-0.0030599695,-0.0984451,-0.04540496,-0.03190077,0.100461885,0.015536632,0.014481965,0.034481358,-0.015632551,0.057908747,0.056241773,-0.0097618755,-0.01028639,-0.01744206,0.043625977,0.076901905,0.0030885467,-0.0009645809,-0.0019442008,-0.0528996,-0.017818948,-0.13229355,-0.018614084,-0.027404448,-0.021677792,-0.025242044,0.054262012,0.024872318,0.0017038798,0.008668,0.024914049,0.04164905,0.032440837,0.07872493,-0.019602545,-0.03489336,-0.037987005,-0.068949156,-0.009437204,-0.013481857,-0.055378746,0.014535917,0.0778526,-0.06628468,0.058259133,0.08188034,0.0506579,-0.007167702,0.0036122878,-0.06438871,-0.0174402,-0.01773034,0.08269305,0.13758825,0.0070796725,0.0675777,0.0035890893,0.07775695,0.12980276,-0.04823292,-0.040147543,0.061717857,-0.035761632,0.0194432,-0.05772602,-0.113816,-0.021529214,-0.022822378,0.05357441,-0.003631907,0.012181199,-0.06180835,-0.041154306,-0.08657999,0.06794981,0.14162606,0.007219068,0.031214146,0.044156823,-0.035250507,-0.057313148,0.059524547,0.12396718,-2.8165092e-08,-0.000626918,-0.0703985,0.03151429,-0.013205222,-0.05092938,0.0011346645,0.023474453,0.053852253,0.08766843,0.02393335,-0.045012936,0.012872773,0.075321816,0.01576975,-2.4127196e-05,0.015805421,9.546723e-05,0.075004876,-0.009554688,0.0564622,-0.028460504,0.038657546,-0.07991069,-0.055684417,-0.011201404,-0.12593935,0.026993055,0.011858697,0.02747385,-0.025920326,0.008999927,0.0037710855,0.04695254,-0.038718835,-0.07863955,-0.06474915,-0.036048625,-0.027793288,0.02769411,-0.058053523,-0.016214153,-0.075584725,0.014076197,0.008871489,0.006148035,-0.009300648,0.02341545,0.00652418,0.023810042,-0.014774003,0.09376882,-0.074644834,0.020296045,-0.15412404,-0.047680296,-0.028699676,0.039142065,0.030369187,0.034012046,-0.102312274,-0.0785856,0.013430001,0.09641397,-0.020333493 +2.5.1.53,"The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Acacia willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC 2.5.1.47 cysteine synthase.",384,0.99999994,-0.06236358,-0.1043386,-0.04645925,-0.04188975,0.0646967,0.11941114,-0.08006814,-0.010013739,0.060971364,0.018523922,0.10891141,-0.06087009,-0.052069094,-0.054174535,-0.06579766,0.027762415,-0.0038830605,-0.043103382,-0.016233658,-0.08556748,0.09134507,0.0036335827,-0.009583939,0.03168603,0.02285012,-0.044670828,0.009445988,-0.063355945,0.027356975,-0.06080422,-0.037225325,-0.06298595,0.04939374,-0.07115097,0.062869534,0.051157285,-0.046885528,-0.074932314,0.0833761,0.031316172,0.039413113,-0.040408447,0.027038658,-0.085109346,-0.03112812,-0.011782056,0.029521193,-0.009133024,0.014337481,-0.008156827,-0.04575103,-0.06044846,-0.0015445731,-0.038626663,-0.045130946,-0.026686246,-0.02173117,0.06102212,-0.034591082,0.03138491,0.023977626,0.068552606,0.0050451793,-0.0645298,-0.015176751,0.0039525353,0.0061959415,-0.03214711,0.070159785,-0.050264213,-0.005188429,-0.06735983,-0.041922193,0.098389745,0.005791466,0.07141212,-0.037105225,-0.012410236,-0.009733969,0.00455053,-0.020929167,-0.0014143824,-0.07565509,0.058410745,0.0013807805,0.019505464,-0.0006327928,0.108387664,0.037122488,-0.038872804,0.014431125,0.016175946,-0.060928825,0.0013806338,-0.05238705,0.020230293,0.038603168,0.054761764,0.008319472,-0.044388272,0.030814867,0.039128102,-0.047553893,-0.13826765,-0.088101976,0.02679292,-0.05638916,0.032909773,0.020363638,-0.03487886,0.019186202,-0.004307687,0.007528476,-0.0058346754,-0.033743367,0.043842003,0.0841184,-0.06360647,-0.05443258,0.008816473,0.07557663,-0.024901967,0.09129549,0.1263803,-0.072823904,0.02714543,-0.11901204,1.47636865e-33,0.05637474,-0.004296034,0.010453778,0.01856246,-0.017859263,0.03503437,-0.025352588,0.020794196,-0.034416407,-0.095959395,-0.09623209,-0.027539121,0.02170816,-0.01762486,-0.02620116,0.0062372102,0.023663878,-0.05523102,0.07258715,0.04767557,-0.02654216,0.030322794,-0.017678704,0.022950405,0.011710858,0.027920887,0.06981637,-0.08362962,0.0066831126,-0.00445633,-0.032350894,-0.08912859,-0.0484059,-0.04226956,0.06355337,-0.052973732,-0.019553123,-0.06596258,0.0033768623,0.078433484,0.04456813,0.04353804,0.09889695,0.020283438,0.050674714,0.0043334938,-0.06337598,0.059207197,0.036835883,-0.01624837,0.03458175,0.014918767,0.12319041,-0.01168978,-0.049369916,0.00024023486,-0.040335074,0.03989959,0.051735222,0.08972832,-0.010138642,0.13622956,-0.036290668,0.054334234,-0.0703016,-0.0033472714,-0.07898892,-0.002426889,-0.0027262792,0.10109793,-0.0341793,-0.078536235,0.043488573,0.034331564,0.09282376,-0.08910543,-0.10774315,0.031739183,0.03350476,-0.013523952,0.010077689,0.020689076,-0.019447582,0.020424554,-0.038725,-0.038980056,-0.0039597233,0.01157242,-0.001265489,0.056508113,0.053579584,-0.03809571,-0.013996974,0.054220855,-0.018867351,-1.7034965e-33,0.043340407,-0.06298786,0.034352683,-0.06587399,-0.06327649,0.029985333,0.036495727,-0.045071427,0.05528231,0.030398168,0.10556059,-0.051204473,0.038384702,-0.0067874794,0.06451765,0.0062357956,0.0024261335,0.038320012,0.020606896,-0.012034005,-0.058363266,-0.027394174,0.023051431,-0.002344369,0.056328073,0.023762278,-0.02447792,0.15675986,-0.0032525198,-0.015246143,-0.0043916153,0.001316378,-0.05265888,-0.061121047,-0.06842093,0.041905873,0.020462736,-0.034102622,0.061670035,0.019920051,-0.029027473,0.008664003,0.021613438,0.06513239,0.026411239,-0.0014444821,0.011310822,-0.043837704,-0.04794493,-0.0037020582,0.067424044,-0.033036742,-0.0036234793,-0.030316854,0.0041858214,-0.008350575,-0.04300589,0.10970274,-0.012280468,0.018824684,0.019821286,-0.06725826,0.012313889,0.032384258,0.01549224,0.035346128,0.01997145,0.058679573,-0.016272042,0.057064835,0.0893092,0.010813049,0.021406054,0.041533288,0.014782473,0.044512533,-0.032125354,0.012537617,0.005376959,-0.08646575,-0.0061547975,-0.021594012,0.04297189,-0.0516873,0.044944927,-0.060508937,0.03381314,0.07015047,0.0053953477,0.05058188,-0.026132103,-0.015531173,-0.10759365,0.029572321,0.14520523,-3.412679e-08,0.0055426424,-0.038142398,-0.004460019,-0.02025147,0.0039022514,-0.016444063,0.020231098,0.009133782,0.0066572186,-0.03177817,-0.044373017,-0.005229119,0.002000977,0.015637817,0.03945962,0.026528945,-0.009333128,0.1101459,-0.012501135,0.07756883,-0.011849182,0.04479582,-0.11314802,-0.02533672,-0.087538734,-0.07943179,0.041873675,-0.010914178,-0.0062164497,-0.009215885,0.005761733,-0.011649236,0.020469595,-0.07748408,-0.06602441,0.02151735,-0.052029733,-0.025968267,-0.027676221,-0.06187613,-0.032178607,-0.013677087,-0.070622735,-0.020940673,0.11072855,-0.05915194,0.013854827,0.009430853,0.016724112,0.032692343,0.051048584,-0.036519844,0.07419993,-0.086079694,-0.029120985,-0.06971104,-0.011997751,-0.055096302,0.021473693,-0.053213105,-0.04431698,0.007273651,0.21766862,0.0067275767 +2.5.1.57,Acts on N-glycoloyl and N-acetyl-derivatives.,384,0.99999994,-0.09584295,-0.08453628,-0.056412477,0.038639206,-0.011068758,-0.0041620135,-0.0068694474,0.0010608181,0.027898837,-0.05552366,0.07071572,0.08669756,-0.10946013,-0.039512455,-0.070654474,0.009134111,-0.006395116,0.008057838,-0.036404207,0.027026568,0.008536972,-0.0472928,-0.010059455,-0.020702155,0.033142634,0.05473018,-0.0058028544,0.052447546,0.05642444,-0.13737808,0.05323456,0.012863544,-0.026852788,-0.023787037,0.020725267,0.030550806,-0.008080361,0.030285377,0.03376,-0.0014407214,0.033626914,-0.061676633,-0.040434055,0.0025384775,0.04284858,-0.080618404,-0.03488154,-1.7228453e-05,0.0019438688,0.059445128,0.003023212,-0.010663343,-0.02817534,-0.029397981,-0.0031207132,0.032800037,-0.17587994,0.001399066,0.0963991,0.06621962,0.032516405,0.0036258993,-0.01783221,0.028547745,0.007990071,-0.010470912,0.106391214,-0.122143224,-0.028266365,0.08892322,-0.05556944,-0.03493362,-0.058174454,-0.07060933,0.0280639,0.032758925,-0.06404748,0.006494244,0.075403824,-0.038018487,0.008035231,0.013519906,0.065656774,0.030897899,-0.0040869946,0.015293051,-0.03430464,0.0021419965,0.04159393,-0.0036145474,-0.028394401,-0.05017638,0.010147822,-0.024814703,-0.04483669,-0.0126964655,0.031584136,0.019337706,-0.04620032,0.06270247,-0.013237003,0.026932811,-0.029717147,-0.030251287,-0.07143619,0.060033947,0.052448697,0.008354562,0.010749695,0.050003633,-0.11170311,0.004436325,0.022666212,-0.029045234,-0.12027821,-0.0055991057,-0.06173456,-0.030629072,0.035418764,-0.06189341,0.0418761,-0.02207925,-0.047361623,0.063314036,-0.042528573,0.12058215,0.040975507,-1.4154109e-33,0.08706588,0.046936255,0.008534406,0.0125031695,0.0539963,-0.068562604,-0.0686273,-0.02454925,-0.010030501,-0.015498261,0.064799875,0.040460978,-0.02958641,0.047915775,-0.03776202,0.049965274,0.012558896,-0.007388361,0.046907537,-0.009952981,0.03888415,0.072189786,-0.05825698,0.0390062,-0.058860023,-0.0070651327,0.008892817,0.08859036,0.030213155,0.0108845495,0.044299304,-0.05753697,-0.04542412,-0.0016500062,0.06170756,0.05581262,-0.057490602,-0.038934316,0.10571729,0.016904106,-0.03386332,0.07015183,-0.01948277,0.028473787,-0.039525803,0.03740745,-0.014799685,0.05420435,0.005083797,0.0037482383,0.026582822,-0.025044348,-0.005083801,0.04278204,0.034335088,0.067375585,-0.07120284,0.01692404,0.018088408,0.042975973,-0.009922039,-0.019763727,0.05282661,-0.090600945,-0.039489176,0.05554129,-0.0807761,0.00021754002,0.032677814,-0.04301581,0.0010535117,0.044012807,0.1359357,0.072331674,0.048545435,-0.020298054,0.005704498,-0.004241519,0.02713172,0.0026148055,-0.017916538,0.026584422,0.009274705,-0.057041477,-0.092897095,-0.06152724,-0.051958334,-0.12266903,-0.03770157,-0.024102991,0.0050866758,-0.053179312,0.0016387798,-0.002235583,-0.018262474,-1.6662326e-33,0.017964903,-0.053092185,0.012994885,0.011355166,-0.12546082,0.039573297,-0.028090676,-0.06793577,0.027270019,0.028395582,0.09081697,0.066298656,0.0071580973,-0.06362755,0.017483946,-0.013978127,0.008497009,0.021965994,-0.015184589,-0.047830645,-0.02662771,0.0646826,-0.011247742,0.083266154,0.014273631,0.013817103,-0.038414396,-0.020313172,0.010819994,0.09902013,-0.00045049246,0.020705096,-0.039253157,-0.015757916,0.007694144,0.08434489,0.025938112,0.07934278,-0.12677856,-0.05577593,0.025678223,-0.014151979,0.12465114,0.05124759,0.06056276,0.071047306,-0.03966887,-0.02663147,-0.057920527,0.00039411412,-0.023109874,0.034702517,-0.069855146,0.063583,-0.0028076668,0.17661573,0.09445049,-0.0033617732,-0.042759083,-0.048285995,-0.026314765,-0.0028002723,0.010217583,-0.052611854,0.025911916,0.012778056,-0.113525644,0.031175498,0.10974432,-0.033389833,-0.02518471,-0.02629502,0.0725203,0.036921136,0.00027880946,-0.075512014,0.050766975,-0.16283324,-0.07892389,-0.06152036,-0.007928898,0.021045633,-0.008121706,-0.022258228,-0.12314817,-0.044390246,0.075389065,0.071356095,-0.0053140866,0.045411162,0.014704028,-0.008062998,-0.028504327,0.013141476,0.025428837,-2.3686242e-08,0.04985612,-0.0104072895,0.024921311,-0.098429866,-0.026838101,0.026739912,-0.022788048,-0.00557798,0.010490186,-0.032144073,-0.05037372,0.11549642,0.017153416,-0.040796228,-0.01830508,0.0674801,-0.04327253,0.04800965,-0.055425487,-0.012885872,-0.11474457,0.026719369,0.018053096,0.007324325,-0.004271326,-0.079040065,0.05075701,0.011053017,-0.046663582,0.054698758,-0.009870888,0.050927356,0.018735608,-0.0139143,-0.0058766417,0.0005935686,0.067583755,-0.024837026,-0.009844955,0.019220065,-0.046091456,-0.030141009,0.025611756,0.037676554,-0.0026431875,0.0148185,-0.018721296,-0.0072447634,-0.029132286,0.08172602,-0.01325472,-0.0039742175,-0.057241894,-0.065462664,-0.09333892,-0.012681586,-0.07628443,0.009446525,0.07853851,-0.030259585,-0.051877614,0.021736031,0.08582824,0.007871568 +2.5.1.58,"This enzyme, along with protein geranylgeranyltransferase types I (EC 2.5.1.59) and II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. A zinc metalloenzyme that requires Mg2+ for activity.",384,0.99999994,-0.08105568,-0.039247863,-0.043552063,-0.012027593,0.07983115,0.04433642,-0.02534628,0.059156477,0.055137556,-0.026393572,0.015824523,-0.066271424,0.0033877704,0.050617743,-0.002821835,0.031673133,-0.020390958,0.032989424,-0.04236034,-0.09254207,0.038975798,0.035106536,-0.05769773,-0.023943072,0.007865458,-0.037666235,-0.010975032,-0.019275133,0.01108755,-0.027454427,-0.06531172,-0.104940265,-0.014136193,0.031311125,0.04577671,0.06878742,-0.08448286,-0.043409336,0.008046553,-0.023058916,0.08680687,0.038667575,0.010910174,-0.041609053,-0.02186186,-0.03489604,0.05571843,0.0040042615,-0.045474295,0.010051432,-0.03836386,-0.024046665,0.03203588,0.08511008,0.045527846,0.071941584,-0.12349846,-0.04450766,0.027376646,0.021017373,-0.04107018,-0.043073103,-0.027146624,-0.09492376,0.032862943,0.0084113395,0.054654904,-0.091954835,0.043984793,-0.037539776,-0.09209765,-0.067726545,-0.0354317,0.07126593,0.007851916,0.014973679,-0.008133133,0.027145075,0.08203807,-0.0699708,0.0369181,0.05215067,0.052170675,0.038340546,0.08197949,0.059066642,0.020924151,0.07968081,0.027527647,0.030496078,0.0649882,-0.01342607,0.018067287,-0.026747203,-0.06422984,0.0042015114,0.05949034,0.00481023,0.061208483,-0.005859762,0.083623,0.028680155,0.018497033,-0.03621341,-0.08767643,-0.014456821,0.021731662,0.12838234,-0.06793814,-0.010950603,0.032919273,0.024507962,0.027341323,-0.0099244295,-0.04488839,0.07505046,-0.0053014043,-0.026898524,-0.020874701,-0.05044027,0.006113964,-0.01593046,0.062111385,0.05622875,-0.035372425,0.022659216,-0.17049097,5.056804e-33,0.003879749,0.05324218,-0.0061610574,0.01234076,-0.02349244,0.034413498,-0.08130513,0.071511835,0.021278089,-0.011837073,-0.041594498,-0.05906953,-0.03399622,0.0012407966,-0.0018590315,-0.06058502,0.0068427157,-0.043802302,0.06183289,-0.057976253,0.004707512,0.0498636,-0.027648762,-0.0076145907,-0.0006236588,0.05445494,-0.05795196,-0.06935048,0.01733581,0.01918316,-0.04656449,-0.07221163,-0.048359767,-0.018272113,0.034128364,-0.02902799,0.022017451,-0.048215948,0.03837741,0.007323835,-0.034174923,0.037532847,-0.033524223,-0.008508219,0.06429731,-0.093244724,-0.022620413,0.092785895,0.008152713,0.041746747,0.029444855,-0.054135717,0.07234032,-0.069712155,-0.10670728,-0.005809163,-0.053748112,0.0029458709,0.034060825,0.061383292,0.0020433492,0.039339025,-0.024221597,0.0442371,0.028906846,0.031558942,-0.15180504,-0.09148905,-0.04811984,0.12481431,-0.024096666,-0.023145773,0.10620791,0.020375932,0.067797,-0.021420684,-0.09606539,0.050216373,0.087891676,0.04155334,-0.08119534,0.008305973,0.009891757,-0.002542119,-0.070498236,-0.080407135,0.033565864,-0.087760404,-0.014178716,0.049467027,0.084676035,-0.01297389,0.00968855,0.09703871,-0.015407883,-5.1597594e-33,0.11401461,-0.044355895,0.064717054,-0.07584792,-0.04617395,0.062737316,0.07061168,-0.091073036,0.040045485,-0.087821364,0.12740982,0.051177584,0.05074781,0.00027348148,0.020439154,-0.06561017,-0.015132868,0.11442172,-0.012036302,0.009302406,0.008137107,0.01977848,-0.019483604,0.044389147,0.018191107,0.03658869,0.04278836,0.07624598,0.025445962,0.10291589,-0.07587922,0.10422155,-0.03738867,-0.06538818,-0.045155514,-0.004510764,-0.004364879,0.016612139,-0.06486373,0.057801224,0.0012768565,0.015236102,-0.008647603,0.07668745,-0.00049240433,0.11794447,-0.009417683,0.039218597,-0.036881063,-0.04897056,-0.008614908,0.0014107933,-0.052635714,0.0046230936,0.014449048,0.04559103,0.020975897,-0.03368,0.032447994,-0.013717203,-0.061893325,-0.003524677,-0.019521896,-0.067801945,0.10217152,0.0134588685,0.011497514,0.025624752,0.07815943,-0.0066092666,0.080662794,-0.0056668967,0.060078934,-0.041407112,-0.012339013,-0.021163825,-0.03104225,-0.04068888,0.022591446,-0.08617848,-0.00805283,0.017383277,-0.003353478,-0.051350895,-0.0011361147,-0.011983041,0.018516397,0.09520418,0.019385517,-0.004041583,-0.08924366,0.036562726,-0.052338835,0.106587484,0.03624546,-5.741812e-08,-0.0219335,-0.041346118,-0.006137096,-0.07745315,-0.019926,0.07280752,-0.02562642,0.026235156,0.010699812,0.008859358,-0.02184327,0.06145743,-0.010311702,-0.043766927,-0.024414545,0.022775255,-0.021839412,0.011559004,-0.014921981,-0.015556938,-0.06029697,-0.051809218,-0.06899843,-0.002063823,-0.016057443,-0.143208,-0.030710652,0.102381885,-0.003094484,-0.03696781,0.010769463,0.018272595,0.07245324,-0.0062782075,-0.010515874,0.015936881,-0.030433044,-0.0530026,-0.0009997352,0.0022784567,0.049343135,-0.008594671,-0.07163917,0.008640694,-0.0011617246,-0.03179456,0.02868328,-0.00494012,-0.037532333,0.028579462,0.029907316,-0.026426405,-0.0009951395,-0.012219823,-0.05442671,-0.046834365,-0.018242866,-0.05096011,0.0086440435,-0.02791602,0.046622846,0.039442044,0.11004704,-0.072497934 +2.5.1.59,"This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Known targets of this enzyme include most gamma-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. A zinc metalloenzyme. The Zn2+ is required for peptide, but not for isoprenoid, substrate binding.",384,0.99999994,-0.07513598,-0.015340231,-0.075015694,-0.0075633265,0.097195104,0.03855343,-0.059394274,0.08910853,0.06472583,-0.0642608,0.022884738,-0.064093724,-0.041246757,0.05055351,-0.0055412813,-0.0008023501,-0.04051413,0.03639469,-0.017641317,-0.051788036,0.047020666,0.057309557,0.0035149339,-0.026054217,0.0027074346,-0.045385122,0.008266425,-0.018896287,-0.005827424,-0.023494372,-0.021855788,-0.10475644,-0.035124302,0.026963934,0.049442843,0.044129595,-0.04669502,-0.059544384,0.014813236,-0.004678853,0.07456812,0.06864509,0.016854575,-0.031859547,-0.008534628,-0.029151373,0.038600862,0.0074191755,-0.061722513,0.0029725456,-0.049272023,-0.078822404,0.0380098,0.041153807,0.032431502,0.046203587,-0.14163937,-0.053660963,0.022906786,0.005031143,0.010270035,-0.03658982,-0.008975713,-0.105890304,0.032645736,-0.017233863,0.05028296,-0.10025814,0.06532662,-0.04729699,-0.120687425,-0.06070121,-0.055747107,0.08862528,-0.0025255855,-0.00015010763,-0.012241913,0.048328433,0.055008635,-0.080143504,0.026337542,0.043566894,0.051252954,0.038618255,0.07825619,0.037112843,-0.0017767537,0.12232171,0.018502321,0.040078156,0.08495951,-0.012924601,0.054138843,-0.023596754,-0.05170217,0.013010845,0.07936582,0.027826702,0.041436683,0.0026173755,0.093886785,0.061396584,0.016544383,-0.04940891,-0.046903566,0.016838832,0.017661264,0.13027035,-0.06555544,-0.05298534,0.009728219,0.006793724,0.06084403,-0.029392047,-0.040528756,0.043990497,-0.00013226678,-0.01447758,-0.03381717,-0.010695436,-0.023827963,-0.02877447,0.042560983,0.08529614,-0.0029560921,0.019556165,-0.1705116,5.6591913e-33,0.011396526,0.052864887,0.010566053,0.019090487,-0.046174414,0.014114103,-0.07687488,0.09350998,0.019780142,-0.03563103,-0.05557552,-0.08732967,-0.011064142,-0.03172679,-0.0043719327,-0.060577396,-0.012654309,-0.023675006,0.06832566,-0.032208376,0.008325732,0.008994197,-0.009422538,-0.016920367,0.04112743,0.033076853,-0.034828305,-0.061875924,0.023385443,0.002282253,-0.03878584,-0.12333085,-0.026148964,-0.0073435428,0.06511934,-0.026666451,-0.0028536392,-0.028136924,0.03892018,0.005373331,-0.02966721,0.031810954,-0.036622126,0.019394696,0.06476762,-0.08001697,-0.04620056,0.0835417,0.02592627,0.027549,0.042392522,-0.070295565,0.033050604,-0.014108927,-0.119558945,-0.012611624,-0.052500263,-0.0028068153,0.034476474,0.06679244,0.014919397,0.05269123,-0.029085906,0.0037522642,0.013449845,0.02410062,-0.12812701,-0.060399704,-0.04639728,0.13747689,-0.01022865,-0.03715104,0.14429457,0.04829187,0.061267924,-0.037503142,-0.10304167,0.0072881365,0.08841126,0.027523594,-0.064681716,0.014062725,-0.012374857,-0.0077166487,-0.06656832,-0.06693215,0.019661939,-0.080382876,-0.0005792261,0.081275426,0.05689949,-0.07316175,-0.012928514,0.08486875,-0.025105927,-5.153927e-33,0.10206615,-0.038842972,0.026267465,-0.06308119,-0.034581568,0.03513255,0.02181577,-0.06567292,0.028993746,-0.07882153,0.13625911,0.03031923,0.08272585,-0.031593878,0.025465038,-0.049878445,-0.027194012,0.09985583,0.026709737,0.000745047,0.00831267,-0.009343783,-0.013980901,0.04217777,0.011697549,0.04172543,0.021326605,0.08450555,0.026924394,0.09891446,-0.058842856,0.06411625,-0.012256591,-0.08220581,-0.05149566,-0.016426992,-0.004286617,0.01870134,-0.03481716,0.015536517,0.005897647,0.0066972147,-0.029623784,0.10315597,0.021131573,0.13833752,0.0018721736,0.005133565,-0.024409035,-0.042315923,0.014984112,0.009051155,-0.024076054,0.037589144,0.015539239,0.056252014,0.009954854,-0.01746048,-0.0033154683,-0.0047902693,-0.06825193,-0.012671667,0.020650208,-0.0509601,0.1038107,-0.011323805,-0.026240142,0.09530671,0.056007784,-0.004971517,0.06283822,-0.00581556,0.06960874,-0.008425388,-0.034858473,-0.018049184,-0.032667585,-0.049827296,0.019759769,-0.07889396,-0.018514555,0.0023172118,0.018302867,-0.05773504,0.020312488,-0.026565403,0.077083595,0.10667793,-0.01096306,0.0013398197,-0.039713923,0.0049227094,-0.021630045,0.07840458,0.03607091,-5.429542e-08,-0.014601978,-0.04790809,-0.011592575,-0.058575794,-0.011164228,0.0635456,-0.008494596,0.035697814,-0.030926416,0.0022482332,0.0071438462,0.06278396,-0.031710524,-0.03306894,-0.0034413692,0.019611295,-0.023954708,0.032912236,-0.014693903,-0.014743734,-0.050546817,-0.024014324,-0.072262086,-0.0024027533,-0.01734505,-0.10999101,-0.005013319,0.110257775,-0.015563647,-0.068973094,0.004462926,-0.005902702,0.06013155,0.035466462,-0.05370642,0.016210869,-0.03520344,-0.056936298,-0.00800886,0.009233781,0.024933267,0.011907492,-0.08564119,0.013999928,0.016505059,-0.042881448,0.033648346,0.024864286,-0.034255628,0.010545953,0.059963018,-0.051181648,-0.01650123,-0.053905305,-0.05093354,-0.022787185,-0.050261986,-0.036071274,-0.0048078583,-0.021519095,0.045622602,0.023049958,0.13403967,-0.034249302 +2.5.1.60,"This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type I (EC 2.5.1.59), constitutes the protein prenyltransferase family of enzymes. Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion [5].",384,0.99999994,-0.09461125,-0.068826996,-0.12560038,0.024640147,0.08021227,0.017533967,-0.019651644,0.010838806,0.07843332,-0.05714302,0.0035383736,-0.035007976,-0.013828181,0.056924824,0.0045856833,0.06359443,-0.005968331,0.048882928,-0.044343673,-0.043469183,-0.051607735,-0.0065990845,-0.016491013,-0.011642603,-0.0054018917,-0.048878767,0.009627767,-0.09687214,0.011912245,-0.02794219,-0.0064516948,-0.09455052,-0.038856205,0.009072888,0.03160154,0.077909134,-0.06649594,-0.073458016,0.025633935,-0.08182182,0.10184805,0.026951073,0.07643375,0.0062204436,0.018892733,0.053103838,0.0057000234,-0.03731734,0.0045962343,-0.005904749,-0.02201319,-0.040501725,-0.032001287,0.031042023,-0.017991573,0.0846008,-0.11411208,-0.064057834,0.073618434,0.07959482,0.019317828,-0.041129265,-0.013817996,-0.06754595,-0.015550376,-0.023713013,0.03079358,0.03120782,0.061870534,-0.009960724,-0.07136529,0.0047181593,-0.07288163,0.056194775,0.0005006288,0.03888885,-0.0154659,0.119178794,0.023309186,-0.06309457,0.042451125,0.027156055,0.14798346,0.02999704,0.09112812,0.013603941,-0.0071513867,0.042211674,0.0059953737,0.03518459,0.058570538,0.02793694,0.058271457,-0.010381192,-0.07375727,-0.010755166,0.044808455,-0.026383203,0.008095149,-0.023615908,0.059180126,0.03221273,0.01441553,-0.028517243,-0.046314526,-0.040879384,-0.036685362,0.115940295,-0.059554055,0.014645414,0.030359607,0.051963557,0.06360039,-0.023089362,-0.053876568,0.0628497,-0.040335417,0.00851615,-0.025682021,0.009193019,-0.0421907,0.028776247,0.028179027,0.009730582,-0.05045482,-0.020302588,-0.093315214,5.1815214e-33,0.011059035,0.023789056,-0.029068379,0.027978938,-0.03671021,0.00545614,-0.057959154,0.04247585,-0.027731873,0.011651025,0.01228461,-0.0684031,0.026315464,-0.00620863,-0.045996208,0.015042267,-0.030051272,-0.0335587,-0.03647587,-0.07695114,-0.043492995,0.09173279,0.00045797983,-0.046052013,0.019546332,0.06556761,-0.07203968,-0.07829399,0.012556905,0.03036077,-0.076936394,-0.06861414,-0.055183195,0.058966197,0.0037008552,0.029725747,-0.031036139,-0.1396845,-0.00083034,0.040669486,-0.044091165,0.004339426,-0.08884222,-0.026341299,0.08077606,-0.025159614,0.047149453,0.06588199,-0.059717428,0.021051303,-0.044475477,-0.046533626,0.0072986674,0.02237279,-0.051488824,-0.04270517,-0.02041688,0.051697195,0.0074212295,0.02573884,0.030095484,0.01578935,-0.09853367,0.041550722,0.035245232,0.07295114,-0.116666555,-0.07705665,-0.03343343,0.13952228,0.022249283,-0.0332747,0.08475014,0.045964606,0.051641945,-0.020379353,-0.025955759,0.061697833,0.057768736,0.052069366,-0.06707988,0.033075176,-0.000504901,-0.031273298,-0.026412006,-0.07585299,0.053628415,-0.05404319,-0.044625293,0.030003674,0.0727249,-0.039179202,-0.025160898,0.09725218,-0.05617832,-4.8519668e-33,0.096544154,-0.04211282,0.020299893,-0.057626203,-0.086671375,0.050865952,0.032279804,-0.0829617,0.033542484,-0.106431626,0.06005935,0.013654343,0.046185214,0.026509196,0.036726948,-0.059542928,0.0150098335,0.020686114,-0.037751347,-0.0042020357,-0.010167268,0.070742495,0.06749375,0.0685537,-0.0085371,-0.037461907,0.07711694,0.051412728,0.055680484,0.09781747,-0.0582538,0.025879158,-0.03847776,-0.03287482,-0.061931625,0.0020847619,-0.038945723,0.08148894,-0.008593895,-0.023481663,0.0052017053,-0.0026650105,-0.034934502,0.02706862,-0.0078098252,0.077741206,-0.05864627,0.051393516,-0.016872656,-0.07284603,-0.006010104,-0.064082995,-0.008113551,0.028770447,-0.06793283,-0.011273453,0.065870605,-0.06949465,0.012720541,-0.07500371,-0.06941431,0.0003525926,0.06729249,-0.020570729,0.063970216,0.10026133,0.05729576,0.04406901,0.05133363,-0.0009484597,0.07902357,0.0086583095,0.03371685,0.040204003,-0.038521092,0.027064318,-0.023453215,-0.06652067,0.0193085,-0.07573388,-0.039100535,0.020044925,0.047408383,-0.06460732,0.058945354,-0.01866989,0.04131292,0.103808664,0.09681836,0.008730579,0.008453405,0.0068742195,-0.008920232,0.09018883,0.08740164,-4.6504795e-08,-0.009831819,-0.0025147183,-0.011770815,-0.025537765,-0.01833487,0.0879267,-0.044223152,0.040833373,-0.08692187,0.043288376,-0.03563403,0.061440844,-0.0033428066,-0.037195247,-0.00035020924,0.06542104,0.0024785593,-0.010873479,0.012187284,-0.04939213,-0.025096534,-0.016464433,0.046709504,0.017653545,-0.03480816,-0.09968215,0.022722237,0.05602501,0.0143960025,-0.09662807,0.049396124,-0.030984687,0.06125555,0.059487365,-0.074211955,0.042928077,0.0012787167,-0.0877906,0.0065764687,0.062025383,0.011271719,0.021236187,-0.08224274,0.007371983,-0.07609545,-0.025679395,0.027968254,-0.015276002,-0.042243343,0.033405893,0.046708133,-0.053788565,-0.031069368,-0.01916091,-0.045363348,-0.016742732,-0.03772248,-0.028219448,0.038983874,0.011795381,0.015826,0.025067415,0.09235286,-0.060480986 +2.5.1.61,"The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active centre. The terminal tetrapyrrole is then hydrolysed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues. In the presence of a second enzyme, EC 4.2.1.75 uroporphyrinogen-III synthase, which is often called cosynthase, the product is cyclized to form uroporphyrinogen-III. If EC 4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I.",384,1.0,-0.06192775,-0.005215598,-0.050257593,-0.038620345,0.04268888,0.026602346,-0.045009643,0.033381067,0.013259905,-0.027220745,0.017304521,0.016812567,-0.029616928,0.00026325724,-0.043670077,0.047866184,-0.1297106,0.016779006,-0.01345328,-0.109638155,0.074976526,-0.0235385,0.023308108,-0.03938433,0.03076973,-0.09324062,0.028886337,0.009907324,0.017127987,-0.023650592,0.0017519123,0.025256544,-0.122147344,-0.06623931,0.09526679,0.07184668,-0.083239295,-0.05020135,0.04881391,0.03053836,0.072668366,-0.05800259,-0.094871715,0.026799193,-0.0739676,0.044665672,0.030756928,0.019682074,-0.026931124,-0.010149772,-0.047178395,-0.021838035,0.017604154,-0.0014661894,0.0057961084,-0.01718304,-0.02193564,-0.020796603,-0.0036734082,-0.044654015,0.0628371,-0.011470974,0.002428007,-0.057839833,-0.018746128,-0.0014678311,0.019827848,-0.053378843,0.087076716,-0.074133076,-0.1114981,-0.018292796,-0.06322616,0.07296889,-0.014355319,0.007190177,-0.024882961,-0.01999153,0.009609424,-0.0052031917,0.044664,-0.0004275759,0.0035692318,0.045763843,0.10247041,-0.011009382,-0.0052660955,0.0483471,0.012270605,0.035903614,0.020935532,0.022585457,-0.014404557,0.02590519,-0.0038132265,0.057835385,0.059547637,0.008556792,-0.010305741,-0.0387471,0.020852655,0.02147417,-0.03230396,-0.0748375,0.04151744,-0.010000777,0.031714987,0.0844199,0.02275739,0.02703459,-0.02875283,-0.039475046,0.048405983,-0.023758458,-0.09145434,0.13837244,0.012562652,0.0126530565,-0.020864282,-0.032845136,0.065498896,0.057955448,-0.020172978,0.060497485,-0.047792643,0.047806583,-0.07396942,4.7900704e-33,0.074323,0.13271494,-0.009268805,0.05570799,-0.08847941,0.020029817,-0.01840924,-0.012845072,-0.056093194,-0.06889712,-0.06234773,-0.060192797,-0.010005749,-0.038140077,-0.09773485,-0.1004352,-0.025699094,0.10658575,0.020202946,-0.056198377,0.035684396,0.10252227,-0.039590985,0.015515462,-0.037446573,0.043214034,-0.019304637,-0.021471879,0.07134997,-0.0008148145,0.027322564,-0.03607367,-0.12823799,0.016762603,0.084966764,-0.09151519,-0.0357197,-0.06938561,-0.012145227,0.04365984,-0.07929715,0.0028707066,0.023056224,-0.07681801,0.07182302,-0.07681378,-0.075935274,0.048192736,0.029266527,0.06286499,-0.041831486,0.01567089,0.07023848,0.043148424,-0.08537689,-0.0637846,-0.012878626,-0.10632655,0.021108652,-0.04060635,-0.020408057,0.110313065,-0.009605322,0.04798604,0.023681412,0.018161783,0.024022778,-0.075234585,-0.030174438,0.09272794,-0.002170874,-0.027114518,0.0015642208,0.036292646,0.09217447,-0.028595261,-0.06041691,-0.013702452,-0.0027233216,0.01013825,0.010695806,-0.027053008,-0.00364337,-0.0422468,-0.044995025,-0.03782405,-0.016825557,-0.04667245,0.015171378,0.022098208,0.03399784,-0.05214279,-0.03236645,0.02120748,-0.017646166,-4.7828716e-33,0.11110785,-0.045863915,0.08481932,-0.05417857,-0.06724039,0.027411288,-0.002799728,-0.09162118,0.010149458,0.050712455,0.05295812,-0.022254588,0.0067676124,-0.07701115,-0.030778652,-0.0072177895,0.04727884,0.0687904,0.035087448,0.082208306,0.010193606,-0.02055537,-0.02320327,0.10579236,-0.025816025,0.009058045,0.04659074,-0.03636109,0.09640873,-0.012569885,-0.0024517588,-0.025610043,-0.023973128,-0.026342643,-0.009606969,0.053883612,-0.081689805,0.04785956,0.040668186,0.020627646,0.048044235,-0.04853048,0.026782682,0.013724538,0.07688982,0.017760534,-0.06611832,0.08329814,-0.01093044,-0.01829213,0.028635615,0.063460745,0.019210607,-0.010307478,0.04534683,0.053105235,0.0064271605,-0.0077254623,-0.050301712,-0.010333859,0.03557586,-0.051246885,0.021659654,0.016011199,-0.026282672,0.065519206,-0.015450844,0.060201123,0.03465166,0.05578105,0.06507637,0.015574604,0.038705926,-0.046992756,0.011086854,0.012868054,0.03125772,-0.032348026,0.02629061,-0.12039652,0.018332332,0.0048747235,0.06911711,-0.095128655,-0.024824293,-0.07073194,0.052933082,0.09291544,0.016163059,-0.037179552,0.008826813,0.0173048,-0.02402819,0.082407184,0.1355594,-4.4956902e-08,0.059296526,-0.0039386568,0.008043234,-0.05458873,-0.025730386,-0.003565577,0.052663803,-0.01579525,0.038093258,0.007815981,-0.0072730994,-0.00071404845,0.088782884,-0.022449084,0.09758554,0.014723634,-0.027967522,0.08820732,-0.00411576,-0.014223142,-0.038074173,-0.022062689,-0.11804208,-0.015498179,-0.014305502,0.002585731,0.07234163,0.024823142,-0.018879289,-0.0026379856,0.08378452,0.034117546,-0.0223488,0.03514294,-0.047662813,0.07975225,-0.068388544,0.009892766,0.02076855,-0.03067681,-0.08471067,0.016363783,-0.049319137,0.03478265,0.025383307,-0.029233169,-0.020730238,-0.037988734,-0.03237223,0.055486333,0.06457138,-0.0132602155,0.024092132,-0.12250533,-0.070438586,0.10658956,-0.02944515,-0.037543956,-0.07413966,-0.10049568,0.023015654,-0.0046468694,0.0827975,-0.0026262214 +2.5.1.62,"Requires Mg2+. The enzyme is modified by binding of the first substrate, phytyl diphosphate, before reaction of the modified enzyme with the second substrate, chlorophyllide a, can occur. The reaction also occurs when phytyl diphosphate is replaced by geranylgeranyl diphosphate.",384,0.99999994,-0.07758581,-0.030175181,-0.0054903915,-0.03244443,0.02818841,0.0021834336,-0.017644277,0.009107475,-0.004777582,-0.0026509988,0.06556827,-0.0019671805,0.015241102,0.016291207,0.0147223435,0.034415126,-0.024284527,0.051282056,0.0007145271,-0.0361274,0.08133919,-0.0063473615,-0.06162228,-0.03170748,0.0358189,-0.013694007,0.06574928,0.018038997,0.08352501,-0.03513068,-0.06883833,0.048654802,0.044115953,-0.05056325,-0.0125851305,0.093295544,-0.05377127,-0.06848971,0.0018737962,-0.011759219,0.014084207,-0.0026337253,0.015849575,-0.042454775,-0.06478414,-0.040145654,0.073883645,0.0058197975,0.00445518,0.02501794,-0.048237883,-0.041096173,-0.054027088,-0.07518494,-0.017505465,-0.028518496,-0.05381977,0.025218278,0.0043951334,-0.015275368,-0.03516977,0.034763053,-0.08329477,-0.013372242,0.0674801,-0.06936616,0.02880497,-0.08386041,0.05830831,-0.00632634,-0.030414185,-0.04119355,-0.049615264,-0.013140877,-0.012794815,0.0018733846,0.016629552,-0.0092784,0.028915338,-0.023382356,0.028671583,-0.017989777,0.017500844,0.021196771,0.060506534,-0.0018126722,-0.024594774,0.05168838,0.04633152,0.017664494,0.09159304,0.05749456,-0.043749288,0.014162926,-0.08254389,0.11440644,-0.08815397,-0.03341141,0.022024987,0.02508586,0.016321246,0.04129347,-0.0341613,-0.009049987,0.0032213998,0.036637377,-0.042290334,-0.002353314,-0.016821606,0.02285901,0.08120519,0.025908122,0.047208738,0.028014567,-0.005614904,0.085155405,0.024062201,-0.09805782,-0.058667604,-0.014244221,0.030911071,-0.019731514,-0.029029999,0.056203444,-0.07209904,0.07162503,-0.097528845,5.9226185e-33,0.026140204,0.022554835,0.019676581,-0.039834503,-0.05160936,0.0058970703,-0.020052176,0.0027624492,-0.04407561,-0.072782576,-0.023151614,-0.0850108,0.014625214,-0.016566899,-0.04378614,-0.06443311,0.033104144,0.028539198,0.10160337,0.03871195,-0.045235593,0.07359507,-0.049925573,0.042889297,0.016698483,0.12341995,-0.0040285713,-0.04506228,0.09810312,-0.005554294,0.08599947,-0.12116404,-0.100461185,0.055049215,0.009982892,-0.0508643,-0.0007877708,-0.045245565,-0.01142709,-0.0031711147,-0.09026806,0.025803935,-0.06325181,0.053922273,0.08082601,-0.097411394,-0.013064661,0.09748794,0.030846067,0.055580523,0.03221933,0.009252912,0.05640261,0.028965693,-0.063663416,0.070199005,-0.02471977,-0.021042142,0.046898805,0.045133013,0.023215882,0.029606722,-0.001005249,0.072383314,0.12163061,0.068664916,-0.050733812,-0.083547406,-0.008457698,0.07875528,-0.06410304,-0.0890255,0.008569224,0.0850544,-0.0053094123,-0.07799126,-0.016686825,0.0054679653,0.012091962,-0.00015303373,0.0056209615,0.021040108,0.06320319,-0.04527208,-0.11777336,-0.0051054037,-0.0069366083,-0.04886792,-0.0031454458,0.005870839,0.062694184,-0.032344885,0.002914267,0.056607395,0.042450037,-5.8612205e-33,0.109717004,-0.03198668,0.046423294,-0.073718764,-0.12635192,-0.0011503211,0.026161177,-0.14683029,-0.022487989,0.014230729,0.03134703,-0.0363966,-0.03095367,-0.047198407,-0.050612617,0.005696102,0.034729943,0.13707376,-0.04934253,-0.005167838,-0.021133488,0.12385263,0.101780035,0.043310635,0.029327013,-0.031209107,0.015242899,0.036473278,0.054598253,0.048002396,-0.03502281,0.036427036,-0.046533436,-0.007502749,-0.009535729,0.053945966,-0.03974106,-0.0152051,0.015641036,0.099439204,0.03189963,0.06883336,0.06189182,0.08688284,0.039043024,0.04735923,-0.058361933,0.03207193,0.0105245365,-0.15235002,-0.032750428,0.042054348,-0.01587371,-0.012703525,0.050385986,0.04403946,0.0779723,-0.025846692,0.03350992,-0.06692182,-0.003943526,-0.04810074,0.021257062,-0.07877381,0.051644407,0.1012675,0.024548855,0.077517636,0.04292406,0.034880575,0.029015385,0.0765535,0.09499958,-0.015068033,-0.039420925,0.06537093,-0.024019172,-0.023423534,0.00038706546,-0.10502481,0.015738538,0.050858755,-0.016873121,-0.026003527,-0.06246518,-0.079626046,-0.040972237,0.06267905,0.036631964,-0.022714866,-0.054012224,-0.03836549,-0.004398553,0.059120536,0.054605108,-4.0041066e-08,-0.04820873,-0.06947075,0.013453845,-0.06847899,0.0022475068,0.10447343,-0.069482,-0.059042145,0.05704942,-0.033736773,-0.064706154,0.02526218,0.0324782,0.026947943,-0.02022026,0.0074895634,-0.028167676,-0.003561733,-0.042576686,-0.047895744,-0.06550229,-0.05822789,-0.09419928,0.10860919,0.03690402,-0.056227006,0.012419719,0.05645183,-0.008954011,0.011250186,-0.005729886,-0.002321378,-0.044156887,0.009315608,-0.015821477,0.04238361,-0.038171407,-0.00019373595,-0.028726023,-0.031149535,-0.0147154275,-0.03747207,-0.031541985,0.00900798,-0.011466985,0.009917086,0.024614185,-0.03903207,-0.01931511,0.056410372,0.058371175,-0.0461749,0.0028696123,-0.03823194,-0.053967144,-0.055248234,0.031979363,-0.07817161,-0.030620463,-0.05945973,0.0016537448,0.054645427,0.10240559,-0.024384769 +2.5.1.64,"In the first step of the reaction, the oxoglutarate is decarboxylated and an adduct of the succinic semialdehyde is formed with thiamine diphosphate of the enzyme, as in both E1 of the 2-oxoglutarate dehydrogenase complex [EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring)] and in the reaction of 2-oxoglutarate decarboxylase (EC 4.1.1.71), which liberates free succinic semialdehyde.",384,0.99999994,-0.039163176,-0.02053205,-0.042965718,0.012364039,0.066771425,0.010781921,-0.06663447,-0.03972083,-0.034174845,0.014556921,0.04782895,-0.032983467,-0.017759321,-0.011536249,-0.06267348,0.003471423,-0.08804902,-0.04631818,-0.03939464,0.0038754817,0.09933557,0.000587456,-0.05590191,-0.0014948549,0.11055574,0.0083253095,0.012977311,-0.06123632,-0.056419462,-0.09364319,-0.012297252,-0.07232478,-0.0147632845,-0.038570344,0.016653204,0.04608276,-0.04898317,-0.023652012,0.048308782,0.050994538,-0.00019094012,-0.06246185,-0.047343697,-0.019978095,-0.060803287,-0.025805838,-0.004325244,-0.0045804707,-0.009922469,0.048905946,-0.04099995,-0.0035475844,-0.02274027,-0.0029068242,-0.0040298053,-0.037838154,-0.012055026,0.03588298,-0.061346974,0.012541592,-0.0034517338,0.013477447,-0.092826925,-0.009483425,0.06902229,-0.09805878,0.029741414,-0.0494829,0.004360366,-0.05268269,-0.06563628,-0.05292258,0.04486434,0.026745435,0.01386568,-0.058286753,0.0058392044,-0.009216992,0.039210998,0.02145618,0.10976653,0.018044027,0.020987088,0.08440183,0.00606268,0.0033301576,0.049351204,0.03180314,0.05006653,0.016169498,0.032281432,-0.00085678394,-0.07747134,0.014104355,0.007887826,0.08021938,-0.00073613995,0.13687733,0.014546747,-0.027525786,0.0093660215,0.013035088,0.010750964,-0.10214528,-0.0532952,-0.005091096,-0.07224682,0.039204378,-0.0030009258,0.055997007,0.07135354,-0.037192017,0.06693268,0.05294866,0.003103192,0.15710205,0.022004463,-0.07562954,-0.026886808,-0.11905128,0.049902804,0.003816809,0.14309385,0.07552468,-0.048945453,0.072537914,-0.13270546,5.1453504e-33,0.020065503,-0.0047300914,-0.02852698,0.013534582,-0.02192651,-0.029539136,-0.10181109,0.07748126,-0.11388961,0.026873574,-0.026771387,-0.009913249,0.040492784,-0.025209684,-0.1133803,-0.06547127,-0.01613938,-0.023756083,0.0070582493,-0.0008927247,0.0017235163,0.09654913,-0.02811519,0.0666105,-0.036656864,0.0016606532,0.0127777485,-0.016137954,-0.02206956,-0.011491978,0.10186664,-0.12111203,-0.07063359,-0.033744935,0.012950041,-0.041431874,-0.058748733,-0.043774556,-0.026021082,-0.0025433977,0.029365817,0.03477369,0.006772433,-0.063774064,0.014690346,-0.03044717,-0.05443474,0.09813846,0.022903288,0.062213924,0.04611766,0.0010392934,0.005370612,-0.041099675,-0.0642982,0.09549706,-0.0072495695,0.016323492,0.12724975,0.04092402,0.018323505,0.026766896,-0.03502545,-0.028970854,0.023515152,-0.022350695,-0.059593312,0.00037335072,0.033421375,-0.017865518,-0.032376163,-0.064053126,0.08098266,0.01495118,0.058236632,0.002741089,-0.044531435,0.10831795,0.0039958274,-0.007902812,0.02317455,0.021731617,-0.006068377,-0.013103055,-0.026302695,-0.03443917,-0.032118123,0.009564183,-0.061070085,0.095831394,0.008269184,-0.03927806,-0.0326658,-0.02933593,0.09344578,-6.4228446e-33,0.12978353,-0.14568083,-0.017941277,-0.057501297,-0.018537909,0.043143533,0.050348278,-0.0015563588,0.039572936,0.031234993,0.10670437,0.023041883,0.014861712,-0.005507576,0.08413337,-0.057137307,0.0065390016,0.023620388,-0.010649153,0.019216262,0.06799877,0.12572126,0.019414607,0.030484617,0.05231132,-0.04629269,0.06567308,0.058912955,0.016531639,0.036200993,-0.044248056,-0.04262558,-0.0100739915,0.030011864,-0.08084452,0.006646675,-0.067364536,-0.027366439,0.0038894538,0.08049068,-0.07077982,-0.006597215,-0.02673923,0.06763804,0.061631657,-0.025155222,-0.11454912,0.0031854652,0.023471886,-0.041887127,0.040181033,8.259314e-05,-0.0562193,-0.032185093,0.021589436,0.03870155,-0.012706519,-0.019454537,0.014560702,-0.038079288,-0.028747376,-0.03550658,0.025563,-0.061620306,0.016434971,0.015263806,-0.073317096,-0.0078049703,0.03876372,-0.032404147,0.059201535,-0.024561727,0.016045315,-0.036753956,0.057526365,-0.09884457,-0.031632993,0.011214434,-0.00945801,-0.05017388,-0.02398877,-0.028558591,0.031293258,-0.025839822,0.04579304,-0.07402827,0.052462887,0.08792288,-0.03230821,0.015276924,-0.033474576,0.01426264,0.008425965,0.0876431,0.08710318,-4.5531227e-08,-0.081873745,-0.034269437,0.055413358,0.024310565,0.0015810911,0.028041825,0.045404013,0.02020408,-0.049173266,-0.031027349,0.00050748227,0.09544726,-0.0018459492,0.07453095,0.03839537,-0.003344561,-0.059697248,0.066545434,-0.034059193,-0.01245021,0.0053641065,-0.026510814,-0.06693259,0.065397434,-0.037689112,-0.018645357,0.07191783,-0.046977818,0.0058357846,-0.081390664,-0.028925655,0.06033281,0.021539865,-0.062129498,-0.058285214,0.030782733,-0.008132923,-0.009864798,-0.009308553,0.00068622595,0.019368548,-0.055998787,-0.002775626,0.012170439,-0.03646671,0.03757017,-0.0020563607,0.007934084,-0.027749466,0.05213976,0.08960192,-0.008123006,-0.013335352,-0.008085237,-0.030113198,0.031858567,-0.033507235,-0.062496275,0.06452852,0.048522905,0.024714774,0.05805345,0.18930954,-0.04990651 +2.5.1.65,"A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine.",384,1.0,-0.021051357,-0.053134367,-0.017741205,-0.04490645,0.11071028,0.03147143,0.00825231,-0.0037328848,0.097983435,-0.03303707,0.018022437,0.015604846,-0.040208638,0.028903691,-0.048185218,0.11557109,-0.050292782,0.016193245,0.01815287,0.0034975708,0.107754745,0.011099521,0.0064641847,0.0188404,-0.0063079204,0.052969396,-0.03387004,0.08220246,-0.018567357,-0.08630494,-0.006039841,-0.012419364,0.041311573,-0.06384667,0.084119454,0.037877817,-0.050830357,-0.028533025,-0.065266445,0.007846251,0.06861544,-0.0062614623,-0.09162099,0.031934552,-0.049750306,0.0022953246,0.07843875,0.039119318,0.06643977,-0.007563215,-0.1041751,-0.094447516,-0.02141406,-0.05490543,-0.021341726,0.084217094,-0.0650749,-0.017910134,0.0149693005,-0.08789731,-0.04382674,0.02197755,0.02738802,-0.01293019,0.08674184,-0.051353205,0.01011461,-0.07592061,0.0069818795,-0.062404048,-0.05405685,-0.0696531,0.05492194,0.06271084,-0.0197662,0.104100704,-0.061089788,-0.034056418,0.017860327,0.0007321003,0.01305793,-0.046554968,-0.05861836,0.06008935,0.050839137,-0.02114429,0.007180542,-0.0018807802,-0.011093119,-0.023617415,-0.009479351,-0.054085337,-0.020695765,-0.006821257,0.0030935518,-0.010292942,0.030155482,0.03231563,0.023446376,-0.04725795,-0.017129576,0.031597123,0.049900968,-0.03763577,-0.065832704,-0.026719993,0.0102499025,-0.00783268,0.035386,-0.033021532,-0.09916188,-0.008196134,0.010440444,-0.01848613,0.0030534773,0.08532967,0.017973183,-0.024197508,-0.044936378,-0.025026165,-0.029740319,-0.051758043,0.008221333,0.11372368,-0.009380935,0.061712757,-0.14966698,1.5601201e-33,0.04086361,0.070603356,0.03405385,0.023526805,0.02416838,-0.009746479,-0.049233936,-0.03904826,0.034515653,-0.050436027,-0.081132255,-0.024258826,0.07920819,-0.013477742,-0.021622453,-0.08436296,-0.037309207,0.00029186622,0.028424019,-0.01943011,0.089639045,0.06701346,-0.06609272,0.042039115,-0.002334347,0.062200587,0.0013855328,-0.0450995,0.046110947,0.006742626,0.016786616,-0.057480816,-0.0787427,-0.04045843,0.03963494,-0.026988866,-0.025441995,-0.0769673,-0.0019430327,0.024961019,-0.109729394,-0.030709155,-0.023461906,-0.04338221,0.013979489,-0.12725854,-0.12491158,0.13145098,0.008066461,-0.012779629,0.047997426,-0.060298916,0.082736075,0.017727572,-0.07149533,-0.01520683,-0.05556152,-0.028034294,0.03345065,0.013408414,0.044181004,0.047558617,-0.0408656,0.0074765254,0.018192776,0.073456,-0.02203008,-0.009845963,0.05646606,0.111562856,-0.0097869905,0.043571625,0.07151623,0.053999223,0.017908487,-0.052648503,-0.115062505,0.043456826,0.04538989,0.06816496,-0.0032062128,-0.03456093,-0.009627466,0.0033211706,-0.06623769,-0.06360438,0.039977834,0.008153945,-0.0030817797,0.07555818,0.06286951,-0.108519346,-0.0033654082,0.060872074,-0.027796883,-2.123051e-33,0.034399603,-0.09206513,0.07812511,-0.028127983,-0.0067181815,0.09212612,0.050770182,0.013203542,0.03093663,-0.013170133,0.033055607,-0.033309873,0.053809993,-0.042192165,0.017234562,0.04028104,-0.055391937,0.039892063,-0.0046523567,0.029331075,-0.026603902,-0.009817849,0.030910214,0.13902956,0.032851387,0.030533431,0.042698234,0.03981288,-0.010021353,0.02548644,-0.03675165,0.09573228,-0.007330992,-0.023353191,-0.0030446178,0.031039322,-0.07202297,0.051132623,0.02388239,-0.019598294,0.014797734,0.022542084,0.04551115,0.06349243,0.035759907,0.08439965,-0.015133883,0.0038068916,0.0016699947,-0.0838434,0.021676308,0.028854137,0.031811737,0.029144168,0.07777828,0.078584656,0.040545505,-0.014834079,-0.010438516,0.013430159,-0.06432458,-0.093533136,0.008850707,0.0631865,0.00940783,0.05175236,-0.0034030117,0.03823786,0.03941912,0.024864953,0.020083003,-0.015018066,0.059080947,0.10570638,-0.01751748,0.034392398,-0.039054852,0.042812668,0.015141082,-0.06902398,-0.040532306,0.017209522,-0.016147828,-0.105588876,-0.009724441,0.0109833,0.03998409,0.06141857,0.013715193,-0.0115327025,-0.004882366,0.011089737,-0.068050824,-0.00023071116,0.12577917,-4.1253255e-08,0.04192167,-0.063457355,0.11214895,-0.011770819,-0.014737208,0.040077105,0.05448365,0.026000129,0.05625808,-0.026114915,0.054067053,0.014493604,0.03378326,-0.0645876,0.027845465,0.048016123,0.015595399,0.04503635,0.029021716,-0.014697081,-0.09146,0.023721727,-0.074832484,0.0036797684,0.0048318664,-0.047136888,0.0067594647,0.016863452,-0.038794562,-0.045961875,0.011047056,-0.017457657,-0.051288445,-0.081374936,-0.12891816,0.06003551,-0.018117487,-0.05858677,-0.059309885,0.0056555485,-0.028985336,-0.012000996,-0.0227368,-0.048314247,0.046200894,0.027161159,-0.032290112,-0.044147797,-0.029920759,-0.04360393,0.058777463,-0.03321817,0.010325258,-0.084857225,-0.120414324,0.036488254,-0.050223235,-0.0769642,0.033990134,-0.06726962,-0.008065193,-0.016093543,0.1329287,-0.03423219 +2.5.1.66,The enzyme requires thiamine diphosphate and catalyses the first step in the clavulanic-acid-biosynthesis pathway. The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.,384,1.0,-0.026763406,-0.030597415,-0.07476568,-0.07123888,-0.0053118644,-0.010751471,-0.06633746,-0.06720421,0.012757383,-0.03390798,0.022371711,-0.061381422,-0.049537323,-0.043588445,-0.046165343,0.013986953,-0.03491203,0.036653593,-0.033925124,-0.024839275,0.09943192,0.0020700216,0.015562552,-0.007864143,0.047372695,0.010972594,0.053705037,-0.016942238,0.05075315,-0.05906081,-0.08065739,-0.04157101,0.03481296,-0.030568453,-0.021246845,0.11982897,-0.0337621,-0.0032276874,0.023082243,0.04384719,0.08863854,-0.0071160225,-0.06506488,-0.022677459,-0.036480453,-0.053149287,0.016299328,-0.019885898,0.015930982,0.007359154,-0.06852066,-0.06168433,-0.056904256,0.001226625,-0.007748116,-0.02391551,-0.011696396,0.058804598,-0.005011195,0.027854882,0.017717041,-0.0064870277,0.026288044,0.025893128,0.08624924,-0.15085249,0.022199735,-0.021923015,-0.06459199,-0.034078993,-0.035606608,-0.036852825,-0.03623175,-0.05887501,-0.03279062,0.07806527,-0.029994182,0.012443674,0.02239047,-0.028518757,0.060789134,-0.025716033,0.023976857,0.1378245,0.015703995,-0.009287892,-0.03668618,0.027446374,-0.056222793,0.021819133,0.08549307,0.03755779,0.0028298844,0.022527896,-0.012390485,0.09683818,0.0033053318,0.014068703,-0.0013421114,-0.010359456,0.001197281,0.059433017,0.0007910178,-0.059700966,-0.05071385,0.020774998,-0.048099194,0.040954515,0.0066110073,0.050908443,-0.015141318,0.049286306,0.031596895,-0.013627767,-0.07121816,0.12373261,-0.050529066,-0.00032274087,0.022354554,-0.043105137,-0.02084657,-0.00674402,0.016977156,0.031309918,-0.051809017,0.056987636,-0.03596249,4.2949155e-33,0.07111475,0.104925856,0.0107360855,-0.048532244,-0.024305731,-0.01236918,-0.070745915,0.01672824,-0.06763259,-0.017615631,-0.051421683,-0.07964628,0.025403796,0.016565245,-0.048560802,-0.024002213,-0.0872122,-0.024583424,0.080140874,0.012596018,0.061912525,0.04381655,-0.08006049,0.028872643,-0.022074355,0.06637708,0.010300617,0.02401646,0.046060886,0.0004056985,0.07989461,-0.09042524,-0.09194224,-0.02846578,0.019138211,-0.07049895,0.017056309,-0.061030895,-0.049870353,0.07937106,0.02537939,-0.026210263,-0.03904701,-0.044163514,0.05458903,-0.059284527,-0.028438216,0.06332729,0.043944903,0.09592984,-0.010651671,-0.04789785,0.09957378,-0.0012119652,-0.077240415,0.014862339,-0.009266737,-0.039134648,0.051004093,0.017441796,0.0030385482,0.05980711,0.046443574,0.032950487,-0.013147505,0.028846132,-0.1488338,-0.047574315,0.028174572,0.037908707,0.013883067,-0.027877701,-0.0017295557,0.029647693,0.036544908,-0.056715254,-0.047859646,-0.03957433,-2.5218838e-05,-0.03490531,0.02158176,0.055222277,0.03776101,0.012621063,-0.011427995,-0.01903968,-0.045334302,-0.024816938,-0.0479351,0.05848892,0.04537488,-0.002895813,-0.025689088,0.022930885,-0.022120677,-4.5758737e-33,0.17674495,-0.064961694,0.08782481,-0.07539117,-0.03983061,0.015598265,-0.012977147,-0.047014434,0.015774788,0.03564166,0.008245696,0.003052405,0.07292929,-0.0403976,-0.011996685,0.0155009935,0.024431719,0.085811995,-0.08203306,-0.026116014,0.048924986,0.095063135,0.02213033,0.094675906,0.025615802,-0.039780803,0.040641565,0.059014697,0.014850857,0.093332246,0.00019677784,-0.0044007874,-0.084928185,0.016024403,-0.036522254,0.08151367,-0.041942097,0.055415887,-0.0047082705,0.09565338,-0.07623469,0.032179955,0.03079393,0.05183472,0.07117684,0.066644534,-0.03764836,-0.028881095,-0.013458752,-0.053209215,0.03842759,0.068970524,-0.0025410524,0.032644074,0.11606213,0.088675424,-0.010489243,-0.037244376,-0.009818799,-0.09486224,-0.029485345,-0.07866812,0.047117833,-0.08064982,0.058286328,0.10273493,0.0017176993,0.09309325,0.04840257,-0.046026736,0.0145845935,-0.012175502,0.030916322,0.037786014,-0.0019782106,0.03294335,-0.09114207,-0.010019454,0.0030530153,-0.009207471,0.018083163,-0.04644418,0.017582947,-0.061457362,-0.0604003,-0.102083035,0.027225846,0.09265306,-0.019327236,0.027871536,-0.0638807,-0.024484307,-0.020537898,0.073246464,0.053232517,-4.1499636e-08,0.017767223,-0.0822772,0.09066057,0.0021324956,0.007522806,0.0474215,-0.042863097,0.013031033,0.064126536,-0.03338927,-0.04018019,0.021037275,-0.00062662736,0.042811606,0.0453523,0.05739596,0.015833475,0.03821154,-0.00968423,-0.036882717,-0.10217986,-0.035988793,-0.07553886,0.0829454,0.07757967,-0.049343303,-0.021164747,0.011298758,0.02692665,-0.018138925,1.7914552e-05,0.022672273,0.01586304,-0.040143255,-0.08998556,0.034615725,-0.02527922,0.008476638,0.012667832,-0.039921727,0.030529855,-0.040892027,-0.041320473,0.02749595,-0.020520547,0.034818884,-0.016768504,0.051189423,-0.077572376,-0.0380332,0.071736306,-0.057600487,-0.021705553,-0.011331886,-0.06271977,-0.0047873817,-0.0370782,-0.041095883,-0.0013034523,-0.050340373,-0.040289223,0.10811777,0.17409784,-0.10422967 +2.6.1.1,"A pyridoxal-phosphate protein. Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. Aspartate transaminase activity can be formed from the aromatic-amino-acid transaminase (EC 2.6.1.57) of Escherichia coli by controlled proteolysis [7], some EC 2.6.1.57 activity can be found in this enzyme from other sources [8]; indeed the enzymes are identical in Trichomonas vaginalis [6].",384,1.0,-0.05290661,-0.121758886,-0.123088405,-0.020133832,-0.013355703,0.050818354,-0.040627956,0.09166557,0.008743797,0.015633,0.06439324,-0.045887392,-0.10124961,0.108317986,-0.042319782,-0.00029639853,-7.886468e-05,-0.021840679,0.03441294,-0.042722367,0.12396476,0.057061765,-0.02398522,-0.042932644,0.03827629,0.029701604,0.01635862,-0.049958844,0.017554633,-0.023573596,-0.06945699,-0.056844793,0.009533908,-0.08477013,0.12359869,0.10418742,-0.07583013,-0.03366677,0.118837945,-0.050756134,0.043552607,-0.11082768,-0.05469815,-0.048451874,0.0015262392,0.028726326,0.057284065,0.025344452,0.043457102,-0.04182451,-0.021690113,-0.006687638,0.044495456,0.023402506,-0.041078072,0.05526954,0.027923927,0.006374927,-0.08049484,-0.014866696,-0.043595996,0.009237117,0.025194352,-0.015478395,-2.0189756e-05,-0.039676372,0.016006947,0.011187197,0.004903221,-0.059645325,-0.034057252,-0.038638078,0.055838596,0.055703208,-0.018637216,0.01021883,-0.013695072,0.0012012775,-0.048130747,-0.058218565,0.03965624,-0.100781575,0.018504787,0.07432574,0.019142888,-0.061210945,-0.0072417413,0.045356747,0.033193994,0.035223693,0.020711098,0.02002774,0.01636772,-0.042054564,-0.06444536,0.01563314,-0.07078833,-0.034634292,0.025384547,-0.07703695,-0.05428996,0.05318809,-0.029366985,-0.0162894,-0.017680395,0.037702072,-0.018054407,0.093988925,0.10464817,-0.0036029066,-0.01859427,0.007986707,0.051658016,-0.022333302,0.006189849,0.04719158,0.04675338,-0.011690457,-0.06877466,0.048126247,0.01824498,-0.057156403,0.08291303,0.068525515,-0.0047393506,-0.0006545429,-0.03127721,1.9024788e-33,0.0980232,0.042877488,0.025936201,0.010437792,-0.03407777,0.07481053,-0.06916665,0.007752978,0.0040944833,-0.13642025,-0.07019863,-0.07099011,0.04576567,-0.016684681,-0.008287989,-0.0034562694,-0.050477076,-0.017025879,0.06089842,0.019101007,0.050858196,0.078031436,0.018165117,0.051471766,0.001319428,0.037827812,-0.03600795,-0.018389918,-0.07866925,-0.00029970953,-0.0046694954,-0.11192164,-0.08686246,0.0037974503,0.0893941,0.030636348,0.005314531,-0.029264534,-0.062442403,0.068480805,-0.03518598,-0.018912481,0.018376073,-0.024312774,-0.007267179,-0.077474296,-0.020186907,0.06589897,0.0056513594,0.08103791,0.003910313,-0.0016914459,0.068755575,-0.03152578,-0.08470248,-0.02052487,-0.006632908,0.009169663,0.052819204,0.052229583,0.073854275,0.027645754,-0.08820524,-0.020241981,-0.06731021,-0.010281207,-0.013584966,-0.039521214,-0.007162361,0.08165845,-0.13074678,0.025045045,0.042860057,0.06376093,-0.028766438,-0.06549182,-0.05700851,0.03065989,0.015326341,-0.03179767,0.014761047,-0.05518648,-0.00074283476,-0.027215572,0.002286991,0.023006922,0.022464182,-0.048764512,-0.005904225,-0.05079758,0.04693139,-0.06284319,-0.018924218,0.04582928,0.04676207,-2.8292942e-33,0.083066285,-0.10118424,-0.003250361,-0.06525161,-0.01517182,0.039684493,0.010657042,0.029847214,-0.04324818,-0.012593586,0.07289315,-0.006748221,0.011438175,-0.050209425,-0.015423489,0.01331299,0.02519981,0.07550243,0.05951725,-0.053896587,-0.02164958,0.08899991,0.006694695,0.022315107,0.07317607,0.07207386,-0.029277232,0.024149185,0.012945013,0.08921752,0.0001746013,0.030084604,-0.023912115,-0.031273898,-0.013463116,0.08161497,-0.050634608,0.01016338,0.053533144,-0.016522769,0.056079604,0.06373078,0.056769304,0.03149711,-0.026930751,0.075299494,-0.0652193,-0.010619728,-0.07164318,-0.070830695,0.07955475,-0.018274345,-0.02003926,0.01522843,0.05622627,-0.01267294,-0.0074377153,0.023151744,-0.045389455,-0.0025073972,-0.028005933,-0.062745206,0.009910987,-0.017841894,0.046560377,0.015299658,0.006833865,0.07476079,0.035987396,0.03312942,-0.0018292745,0.016541924,0.0046755653,0.05820555,-0.06454421,-0.07678964,-0.062831745,-0.024130158,0.045824595,-0.04168398,-0.06638142,-0.04231765,0.024658725,-0.095371395,0.026285592,-0.06355634,0.0044610575,0.092083745,-0.0025352547,-0.006315618,-0.06861568,-0.007891385,-0.013533407,0.05850876,0.08018751,-4.6473733e-08,0.033264235,-0.04697443,-0.0012765989,-0.051851224,0.09476392,0.012905972,-0.009144866,-0.014634345,0.06678981,-0.0675657,-0.040764034,0.033860803,0.018150337,-0.015779577,0.0342313,0.09599882,-0.034477387,0.091200545,-0.009692015,-0.007824391,-0.05937461,-0.041433807,-0.1681295,0.005788801,0.021691736,0.04386936,0.014719553,-0.0074413307,0.027259808,-0.05508938,0.011362845,-0.006793373,0.05212467,-0.012994808,-0.05167533,0.053617544,-0.029955307,-0.009855817,-0.04124195,0.02405891,-0.026773166,-0.031150803,-0.060963266,0.020154191,0.037555035,0.06700576,0.021994216,0.03774166,-0.03497903,-0.051033683,0.07404124,-0.06303054,0.015671244,-0.008415617,-0.13825236,0.031128088,0.025784703,-0.064020075,0.020806044,-0.06644228,0.055117246,0.022181256,0.1804853,-0.02436372 +2.6.1.2,A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of 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+2.6.1.3,A pyridoxal-phosphate 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+2.6.1.4,A pyridoxal-phosphate protein.,384,0.99999994,-0.027926307,-0.082669966,-0.06864404,-0.0736116,0.027612139,0.00069278304,0.043136388,-0.0022198383,0.07759752,0.061581366,0.050052542,0.024383662,-0.07972978,0.075630225,-0.018062996,0.011146767,-0.058814332,0.026981099,0.028646505,-0.060484987,0.08062581,0.046058796,0.013964545,-0.0034948976,-0.022635197,0.09317548,0.03897881,0.08481283,-0.022757838,-0.06512055,-0.033645604,-0.002438178,-0.04265655,-0.081326276,0.049699727,0.09206192,-0.10426549,0.024624566,0.01641356,-0.038264256,0.09138554,-0.06995117,-0.019178458,0.015225969,-0.079754055,-0.009005391,0.060174454,0.06121611,0.1076781,-0.0044863066,-0.08720911,-0.014019634,-0.013987518,-0.049955927,0.010103739,0.04439458,0.025756652,0.03877331,-0.030249724,-0.031439897,-0.018875996,-0.014899653,0.033183742,0.03005634,0.045147188,-0.03863779,0.011696549,-0.046883464,-0.028674698,-0.0040879943,-0.0399809,-0.0017529497,0.12130531,0.0010538863,-0.034636367,0.09728037,-0.028074443,-0.023704544,-0.04040873,0.055432733,0.03498061,0.00886843,0.038521856,0.08173242,0.056242175,0.02956211,0.015032759,-0.008670652,-0.0671204,-0.03498028,0.0024070852,0.025017837,0.033844747,0.03431295,-0.017365431,0.020294111,0.0095834825,-0.017277373,-0.049156386,-0.05037137,-0.0135520855,0.006560372,0.029906176,-0.04925029,-0.040218767,-0.005961301,-0.070319004,0.04136831,-0.008511003,-0.0040058997,-0.05803713,0.0810462,-0.012979407,0.006107804,0.023426063,0.022639925,0.016739301,-0.004660274,-0.05652102,0.057704583,0.0031750596,-0.032194667,-0.030190036,0.08859248,-0.054773755,-0.0542106,-0.07686096,-2.4678308e-33,0.06313784,0.074121,0.050783433,0.040298108,-0.011358971,-0.014224093,-0.06284932,-0.054584622,-0.06972202,-0.006010194,-0.005837788,-0.041249312,0.07401363,0.007710753,-0.07779482,-0.03148981,-0.09894455,0.03780528,0.09449977,-0.054316152,0.036347546,0.122786574,0.015729465,0.06573166,-0.023447253,0.10535222,-0.04718892,-0.017551308,-0.020911029,-0.010473525,0.017130276,-0.08890346,-0.10486213,-0.037216794,0.029635139,-0.1032107,-0.053137314,-0.088244945,-0.028490026,0.010690034,-0.031340834,-0.06654564,-0.015844474,0.03225437,0.005228752,-0.12502499,-0.022130616,0.049036965,-0.04441586,0.030425001,0.03924025,-0.065284304,0.07721513,-0.0022649365,-0.14055419,-0.054724984,-0.056979842,-0.04121839,-0.0039615375,0.036306877,0.055933136,-0.0074688112,-0.0776967,0.005927369,-0.007340223,-0.05244896,0.01644481,-0.06923204,0.06292541,0.08146769,0.070626065,-0.021183291,0.08123207,0.022367109,-0.017924992,-0.0069551063,-0.03999482,0.04453336,-0.028805178,0.099463925,-0.02261902,-0.0688775,-0.055661384,-0.03151839,-0.050702408,0.0006394455,0.025497343,-0.05753736,0.047344767,0.00027531275,0.030769043,-0.11320937,-0.0680435,0.018650109,-0.030141242,3.6575068e-34,0.07618561,-0.056287874,0.10101466,0.007109189,-0.055663213,-0.0030681002,0.0774277,0.02046836,0.023406582,0.0041982206,0.0350583,-0.0105334455,0.015140504,-0.066251345,-0.004752528,0.054859713,-0.009271968,-0.005652817,0.058509693,0.04026011,-0.003693155,0.011792269,0.016480174,0.09651126,0.053761203,0.075716525,0.01452238,-0.0019530556,-0.07552723,0.029911192,0.030482544,0.07004557,-0.04148779,-0.061042886,-0.052007284,-0.008271353,-0.09736277,-0.01278196,-0.0069765327,-0.020985939,0.016151197,0.05498444,0.06282519,-0.0045872508,0.010520141,0.042866427,0.027957102,0.024932979,-0.0021861685,-0.041766163,-0.009070528,0.099440955,-0.00797877,-0.04209437,0.04130011,0.01732226,-0.047809716,0.014699099,0.035344053,0.037282605,0.0067929225,-0.06915579,0.014899704,0.10745321,0.030028766,0.10507638,0.046958737,-0.016195957,0.036776062,0.07768746,0.059881773,0.040236715,0.05812127,0.105743006,-0.04496424,0.016713494,-0.05329847,0.07651241,0.00803724,0.014868353,-0.019268366,-0.016083399,-0.04608814,-0.091910556,0.043844398,-0.024019118,0.045906533,0.054757874,-0.007998638,-0.026156204,0.031497672,-0.009735406,-0.027109524,0.037469666,0.07564672,-1.9977723e-08,0.09066985,-0.047100395,0.021396253,-0.09606707,-0.0063670287,-0.0071035447,0.06365685,0.0046283896,0.061157417,-0.0008820098,0.024579087,-0.020273905,0.047039416,0.004775769,0.032485493,0.075822994,-0.01940812,-0.021913694,0.019391755,-0.07981513,-0.04740351,0.001936404,-0.10317189,0.00753118,0.07142017,0.010388294,0.004406259,0.008331364,0.0018802646,0.00193429,0.06103492,-0.033622324,-0.007979489,-0.078628175,-0.0016374547,0.089614056,-0.01480436,-0.025552817,-0.07120053,-0.016167747,-0.08352152,-0.0088831885,0.02011399,-0.038908735,-0.0075784125,0.06274982,-0.060978554,0.019942068,-0.035090562,-0.040864546,0.038964637,-0.0051312405,-0.07638949,-0.080362394,-0.15321009,0.04632519,0.039614286,-0.041317645,-0.012306477,-0.087682545,-0.037958488,-0.054651886,0.07941697,-0.07056297 +2.6.1.5,A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8].,384,1.0,-0.0644254,-0.04336197,-0.075895295,-0.0646075,0.024580747,0.08528299,-0.13846754,0.009990231,0.069036536,0.0073768427,0.071762726,-0.0674966,-0.00681393,0.038522426,-0.008245741,0.02545033,-0.14041075,0.019209,-0.027804838,-0.063026726,0.06336946,0.072568074,0.019381786,-0.037522376,0.048918884,-0.018218983,0.010135628,0.0015867089,0.015955439,-0.071009904,-0.01096639,-0.028635945,-0.004438864,-0.03969122,0.04513551,0.07725778,-0.05572674,-0.043407604,0.059106447,-0.0024373238,0.039501064,-0.042059142,0.019152118,-0.046528254,-0.054323893,0.020020049,0.016820604,0.053029988,0.055769578,-0.07292074,-0.051243283,-0.07683287,-0.010589387,0.012692437,0.00040795174,0.14028682,-0.06161326,0.017312927,-0.023988573,0.03947499,-0.0028516883,0.019054467,0.000117497664,-0.037822697,-0.020495486,-0.06717978,-0.010706297,-0.078506835,0.06875751,-0.034426425,-0.006405233,-0.11634509,0.050138533,0.06475067,-0.04004069,0.066975415,-0.05854825,-0.00429233,-0.04208092,-0.026715713,-0.031878944,-0.074112564,-0.010527628,0.045019533,0.04825806,-0.08085612,-0.027033145,-0.00395988,0.033809163,0.023688896,0.060962588,-0.0045361207,0.010051412,0.0049447254,-0.08303561,0.014520993,0.034009207,0.077574976,-0.033552397,-0.0087806955,-0.042339288,0.07733317,-0.03339757,-0.058470342,-0.0680548,-0.035131343,0.023759555,0.021417174,0.019263353,-0.04991141,0.03502279,-0.028914742,0.013228619,-0.042658035,0.028572824,0.06352985,0.045334645,-0.08824391,-0.04480688,0.022949927,0.01852203,-0.045480035,0.100157775,0.03885978,0.0043997453,0.043798726,-0.019579442,3.6537024e-33,0.08391157,0.090952,0.069294386,0.034469344,0.004573667,-0.074972056,-0.10766624,0.0048964135,-0.0014911257,-0.15367803,-0.058903184,-0.0072342786,0.0067844936,-0.014422599,-0.04037574,-0.026954543,-0.06403177,0.018877419,0.056413013,0.035194434,0.063021585,0.012521715,0.006339747,0.04032991,0.061946936,0.010872958,0.029857984,-0.016750338,0.08517172,0.013179678,-0.007000516,-0.0946282,-0.12933555,0.007253903,-0.08226788,0.06010014,-0.1092674,-0.050888296,-0.07128932,0.08195593,-0.03673957,-0.034146152,0.0049668984,-0.029840853,0.007829039,-0.0628274,-0.010620305,0.008786327,-0.0015292766,0.029269837,0.07372816,-0.07713131,0.11615892,0.0033988203,-0.023920787,0.027600532,0.025932029,0.00017181953,0.060886826,0.06253599,0.1258009,0.0071633775,0.0008570644,0.036287475,0.038689427,0.014071459,-0.043139342,-0.043976985,-0.051360242,0.04577397,-0.024567725,-0.04799025,0.075207226,0.017129727,0.03958373,-0.02424096,-0.07699462,0.010732059,-0.03899474,0.0041540684,0.016835468,-0.03466764,0.019562483,0.0075449254,-0.017039979,-0.033399466,0.0031251009,-0.034101456,0.0131865,-0.0014513303,-0.0025790564,-0.04691335,-0.020100411,0.05092433,0.024532752,-3.076652e-33,0.10006546,-0.109545335,0.049545567,-0.0716247,-0.034034323,0.10720641,0.032490507,0.004251458,0.027301166,-0.066229835,0.09191646,-0.027630478,-0.009928359,-0.06790295,-0.0289427,-0.020787949,0.023110462,0.107849345,0.015547724,0.021071633,-0.033900462,0.054217633,-0.0016176183,0.04831145,0.085397825,0.03729174,-0.0030784567,0.06733627,-0.01045937,0.019292446,0.01528376,0.026877334,0.005532715,0.0024112335,-0.05720148,0.0840666,-0.041940615,-0.021754773,0.07114259,-0.0066394885,0.011208728,0.04376059,0.01272591,-0.013775017,0.046709456,0.030191315,-0.048547268,-0.06878029,0.0050034896,-0.08992718,0.054772474,0.016617473,-0.018971859,-0.024709204,0.017921008,0.044988915,-0.017559268,0.019376488,0.034696724,-0.050881796,-0.044540677,-0.06820799,0.028871836,0.043200307,0.03705484,0.030851414,-0.028520985,0.07942456,0.02067298,0.032532245,-0.0295324,0.015190322,0.04290537,0.1022084,0.014860118,-0.04795133,-0.01668277,0.04239119,0.03225412,-0.08925125,-0.053796798,-0.10284047,-0.014171679,-0.06535608,-0.005525292,-0.03521055,0.047110323,0.020057727,0.01620417,-0.010345331,-0.022367401,-0.018455932,-0.030661736,0.09411738,0.074938856,-5.023095e-08,0.13324496,-0.07968723,-0.009241996,-0.022730306,0.058395676,0.03392676,-0.044146333,-0.02247055,0.09283996,-0.0500877,-0.04175928,0.012172241,0.03511073,0.0049706814,-0.030756036,0.08663826,-0.07329002,0.014499878,0.012335553,0.029770512,-0.010130087,0.004591378,-0.09977155,0.040690824,0.08553644,0.019111468,-0.01950952,0.05787321,0.007805183,-0.050205167,0.017886164,-0.003584422,-0.025430158,0.032041874,-0.018581804,0.03184882,-0.034444958,-0.039228737,-0.0356436,0.06952527,0.036562324,-0.038429625,-0.087647066,-0.0061216652,0.03541672,0.035827447,-0.0101479655,0.045993283,-0.036989275,-0.031202497,0.056711566,0.0170687,0.0155238975,-0.055063475,-0.13764638,0.07027498,0.025228627,-0.033289753,-0.014674667,-0.07707731,0.041059233,-0.015871039,0.15497509,0.001511582 +2.6.1.6,"A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.",384,1.0,-0.04325477,-0.12463343,-0.039404433,-0.06658542,0.032993298,0.0034488533,-0.083444305,0.04011144,0.060650855,-0.021349704,0.07231582,-0.00068782637,-0.06742743,0.07940744,0.029781364,-0.028576775,-0.08908346,-0.016958341,0.019102069,-0.048617203,0.0915356,0.022220336,0.0077221687,-0.037528962,0.040844947,0.025436284,0.041610196,0.0818523,0.025068706,-0.07925444,-0.02434399,-0.051673155,-0.0795813,-0.06484772,0.05454759,0.099395745,-0.0999919,0.004421402,-0.02532392,-0.028605843,0.066846475,-0.049689036,-0.024326028,-0.00045682388,-0.019537037,-0.016662762,0.007542595,0.0005704252,-0.010709607,-0.0074239373,-0.025008753,-0.05596537,-0.024001706,0.007825905,-0.05219301,0.058057386,-0.03279363,0.03153062,-0.01171906,-0.01759852,-0.062497433,0.058306977,0.0065286113,-0.017672718,0.05275574,-0.015120699,0.049805336,-0.09287747,0.01709698,-0.09635332,-0.03051704,-0.07736728,0.039139237,0.07355139,-0.05330073,0.009400587,-0.09194566,0.0051812115,-0.06688713,0.0019477279,-0.029120473,-0.049370915,-0.055333883,0.03368829,0.022605456,0.007744208,-0.023924878,0.01650877,-0.06138626,0.007674279,0.05844333,0.012657835,0.0029874807,0.008689155,-0.03521067,0.051321402,0.010158574,0.1064953,-0.024143506,-0.048153885,0.033354253,0.082676515,-0.08746457,-0.02748359,-0.013268287,0.018257776,-0.018570494,0.015315401,-0.010855549,-0.06889229,-0.0053504864,0.025512734,0.027292544,-0.011282742,0.023509735,0.07627757,0.06137531,-0.02309836,-0.025424954,0.07895998,0.024785513,-0.036953077,0.09585774,0.09570206,-0.014074058,0.01572924,-0.06532888,-5.140032e-34,0.08422531,0.02957551,0.05822016,0.04405611,-0.029735034,0.011026627,-0.0810923,0.029441023,-0.022154512,-0.08498195,-0.06282481,0.039932683,0.058494583,-0.0010414041,-0.0027440754,-0.0010906023,-0.05096788,0.011270298,0.09915981,-0.043741535,0.041385,0.03870341,0.033401493,0.077360705,0.031161262,0.029085489,-0.01763164,0.008433422,-0.015121633,0.024872778,-0.05394226,-0.12533697,-0.06487921,0.014585401,-0.004426921,0.0027728411,-0.047809783,-0.06361389,-0.029770166,0.011840918,0.019120429,-0.07096765,0.018127682,-0.010054012,0.02930664,-0.09259266,-0.032362062,0.013226035,-0.046835903,0.029986482,0.079251,-0.06793953,0.082796715,-0.028651673,-0.07268829,-0.030107545,-0.0060589905,0.020923648,-0.018618183,0.09986085,0.12685353,0.07408493,-0.021992495,0.046239324,0.01518707,0.0018862956,-0.051893067,-0.08701236,-0.050931796,0.09419141,-0.041877925,-0.0016428462,0.07343513,0.050647873,0.05483888,-0.037818257,-0.08064263,0.051904947,-0.024468493,-0.010589775,-0.052487977,-0.025365327,-0.029325498,-0.021667648,0.008914609,-0.035680354,0.07992586,-0.05800277,0.0034529169,0.028373528,0.07023397,-0.0597485,-0.059233923,0.01740937,0.056011923,-7.6003185e-34,0.0334096,-0.06925714,0.062567584,-0.04754398,-0.03917553,0.0032188494,0.05824986,-0.0111464355,0.06220102,-0.025189944,0.09746864,-0.026038816,-0.063292176,-0.07881916,0.05482402,-0.038129486,-0.017283883,0.026668478,0.08671074,0.013826405,-0.055885136,0.06973038,-0.022403609,0.07069481,0.048618224,0.041055463,-0.010629106,0.029584289,0.025458537,-0.004797136,-0.020765634,0.06548107,0.03441706,-0.007524893,-0.06183746,0.030054819,-0.076104715,-0.010051771,0.06430538,0.013794659,0.023793017,0.097392246,0.03799206,-0.04274368,0.013993435,-0.0050800834,-0.04192017,-0.07286045,0.0012198864,-0.092825264,0.08172327,0.039424043,-0.0030696632,0.011129543,0.039155398,0.0103680715,-0.06362469,0.06722429,0.034255214,-0.02457136,-0.022624072,-0.058789063,-0.0005062174,0.047036044,0.036708575,0.018577198,0.026212418,0.011923068,-0.009171932,0.06458163,0.0722105,-0.054774497,0.029179344,0.0948883,-0.039017625,-0.014552143,0.0152932415,0.07233035,0.033524662,-0.119493306,-0.015635377,-0.0045044175,-0.019267501,-0.102592915,0.012581029,-0.023961477,0.0016761936,0.08114165,0.04831979,-0.016814014,0.03692481,-0.017205268,-0.05795115,0.014799986,0.10581548,-4.1816772e-08,0.083135255,-0.029192753,0.019360632,0.009658618,0.021930676,0.00977558,0.06259091,-0.05567402,0.04374422,-0.01087566,0.00013027065,0.047033027,0.030766394,-0.03681206,0.025991471,0.12255933,-0.06840169,0.056513168,0.032146614,0.04345115,-0.048663147,0.01277765,-0.13382928,0.0023067533,0.011563277,-0.014266597,-0.026719004,0.05139273,0.018039927,-0.048940856,0.08133819,-0.030958984,0.03789028,-0.040728245,-0.063128866,0.029849112,-0.03185324,-0.037647784,-0.050673235,0.07744257,-0.016681114,-0.077747196,-0.061804906,-0.031464186,0.011366618,0.021883043,-0.0027304138,-0.010318309,-0.01868199,-0.0043220483,0.03845386,-0.02076805,-0.024642007,-0.13283342,-0.110190116,0.025586743,0.009082308,-0.047368806,0.012091469,-0.12962301,0.08134876,0.019675847,0.14226235,0.013041457 +2.6.1.7,"A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.",384,1.0,-0.026395852,-0.08048554,-0.008603465,-0.07291398,0.00081868167,0.04914677,0.040290147,0.01351375,0.024857905,0.08824052,0.07353147,-0.04424585,-0.05856095,0.04681088,0.0077645555,0.11718411,-0.05072878,0.07913116,0.027058916,-0.029883275,0.068317264,0.029911365,0.020421831,-0.035715025,0.0048106257,0.11730924,0.072137885,0.014958818,0.063323654,-0.03231021,-0.025296213,-0.05918939,-0.051773474,-0.04807739,0.08287432,0.08843343,-0.1265607,0.043282162,-0.04468594,0.02789953,0.11019617,-0.037125446,0.009595694,-0.0032551114,0.007962738,0.01419025,-0.007570087,0.0025588758,0.053199917,-0.02673712,0.0045608277,-0.014360371,-0.062317733,0.054010738,-0.0032918898,0.008087826,-0.05456908,0.05352776,-1.604058e-05,-0.0043897796,-0.016143382,0.07475205,-0.01545194,-0.029233944,0.1429998,-0.04055967,-0.029433046,-0.017227186,0.014409241,-0.036679883,-0.017047333,-0.034940667,0.08152728,-0.0076203695,-0.037912283,-0.002137886,-0.025636215,-0.0009408415,-0.036125857,-0.012085151,0.01937249,0.001241264,0.038392194,0.06704901,0.015757224,0.007091989,-0.07911113,-0.03286866,-0.017747018,0.0030691458,-0.038551196,0.056931626,-0.006102142,0.006122413,0.010714534,0.035161357,0.0138559695,0.0009116784,0.050598346,0.02784647,-0.03443479,0.08856616,-0.08470678,-0.12719887,-0.101318024,-0.025199298,-0.06931037,-0.01149144,0.034238823,0.07274975,-0.054346364,-0.00097479863,9.6244585e-05,-0.0030175103,0.0030452975,0.059763324,0.03609259,-0.05298439,-0.024307009,-0.021246614,0.02036844,-0.046516057,0.018304728,0.07587359,-0.09164076,0.046270028,-0.012288317,7.2161325e-34,0.09318296,-0.0006586001,0.041809477,0.08385554,-0.018955516,-0.014742056,-0.039548792,-0.076201685,-0.049233854,-0.033267867,-0.028826954,-0.046186987,0.08497419,-0.019494997,-0.073021695,-0.048548974,-0.08706993,0.048231553,0.11415339,-0.042172268,0.04808205,0.09658628,-0.049827605,0.058991253,-0.048632804,0.057829414,-0.024941891,0.0032978645,-0.0032269352,-0.0036231165,-0.026224652,-0.0489201,-0.11933356,-0.061703317,-0.038379285,-0.07421824,-0.08415349,-0.083945416,-0.024880107,0.028644787,-0.08126902,-0.08301068,-0.04576302,0.0001847539,0.06396397,-0.055676393,0.00795238,0.025657015,-0.011392701,-0.0009860905,0.09104906,-0.08398912,0.06875167,-0.0050606746,-0.10660923,0.0044455943,-0.011647064,-0.098332144,0.05537172,0.038795035,0.07600777,0.05360168,-0.05843833,-0.0031490938,0.0011877955,-0.032346338,0.008724617,-0.091809966,0.0059627187,-0.006891217,-0.0105759995,-0.021000685,0.05460613,-0.01705049,0.018429786,-0.043643247,-0.063286744,0.06898931,-0.031633053,0.010649925,0.04445194,-0.018702378,0.0038551316,-0.024988493,0.01956637,-0.0035865123,-0.0004779821,-0.083750434,-0.0035414207,0.05419137,0.07791028,-0.1138546,-0.03476927,0.010346189,0.018758161,-1.6913999e-33,0.051965017,-0.07821717,-0.01227232,-0.0015409702,-0.0028654132,-0.013232675,0.051354088,0.036106385,0.039125327,0.041470136,0.101247765,-0.059696585,0.016517397,-0.009260863,-0.01107841,0.05193687,0.03578078,0.037850294,0.030589899,0.036991592,0.09812728,0.01819818,-0.043353222,0.080678865,0.025993424,0.038731832,0.03546746,0.049826458,0.0097566685,0.055269193,-0.022937298,-0.011188565,-0.04279821,-0.021718245,-0.076959774,0.017551603,-0.107071176,-0.030395607,-0.034010913,-0.02590212,0.016450837,0.069487065,0.044348907,0.049389098,-0.0016959879,0.039050844,-0.044376012,-0.048272748,0.021273004,-0.06275548,0.01557276,0.046519235,-0.026622979,0.0051832297,-0.006790576,0.08015816,-0.05061409,0.028300975,0.03583107,0.012899873,-0.022379767,-0.16108438,0.03989473,0.015024666,0.0777462,0.10897394,0.046593737,0.06283668,0.07496191,0.009279715,0.03862404,0.03185895,0.08992113,0.03312542,-0.0095824,-0.061344407,0.0038189478,0.054197375,0.03391311,-0.027552413,0.0035574427,0.014048306,0.0011727118,-0.08728934,0.033309247,-0.05018789,0.021502072,0.12442399,-0.015833637,-0.0051848125,0.03448878,-0.02352653,-0.044426285,0.039961275,0.06967529,-3.5992528e-08,-0.006189247,-0.088609934,0.04593162,-0.03175098,-0.059700456,-0.03153931,0.07045711,0.006761061,0.051157035,-0.077511854,0.042963926,0.021325083,0.024970105,-0.02192602,0.095988855,0.057291776,-0.021433214,0.06948396,-0.02485934,-0.07595151,-0.06669225,0.009791536,-0.05396125,0.024586309,0.0135607105,0.0052607995,-0.012279561,0.05004749,-0.0036319734,-0.01771135,0.043770913,0.01450482,-0.041206874,-0.048660856,-0.06954009,0.039363742,-0.014393169,-0.02591681,-0.0073623154,-0.08412367,-0.08741211,0.013927926,-0.054631177,0.018351436,-0.015332609,0.04950862,-0.032125294,0.00694215,-0.0132047655,-0.008865757,0.073245205,-0.028452437,-0.020268124,-0.09794512,-0.10587011,0.00904521,0.021105299,-0.056744058,-0.025454238,-0.08700138,-0.0059651346,0.011068907,0.11412664,0.03451086 +2.6.1.8,"A pyridoxal-phosphate protein. 2,5-Diaminoglutarate can act instead of diaminopentanoate.",384,1.0,0.020145439,-0.114430375,0.02087426,-0.101525865,0.022433154,-0.043457657,0.061175667,-0.0062882393,0.018213956,0.06742996,-0.020804746,0.024935873,-0.07173392,0.123766944,0.022834852,0.03778116,-0.04505842,0.048916962,-0.033264376,0.005972946,0.16298762,0.04658124,-0.009731838,-0.04275405,-0.018032098,0.06972287,0.035138424,0.04674924,0.010994098,-0.13328831,-0.12029747,-0.028954657,-0.07089373,-0.11951835,0.063478746,0.066006735,-0.08505983,0.009143866,-0.037996847,0.038032737,0.08377874,-0.015392747,-0.035506587,0.012088002,-0.034381505,-0.005341486,0.007187836,0.040910978,0.098652914,0.0074592773,-0.088277824,-0.033630606,-0.019516524,-0.023311514,0.00039838013,0.02917757,-0.025941938,0.02988896,-0.042506304,-0.0134029975,-0.0037479298,0.0034225197,0.011416146,-0.06542747,0.07488409,-0.042467598,-0.010604994,-0.042271778,0.028523257,-0.026423702,-0.05196124,-0.033169664,0.09414583,0.0147085935,-0.003396082,0.02488064,-0.053828012,-0.009742428,0.012590348,0.026147924,0.07705957,0.0595918,0.041924614,0.04719912,0.014028385,0.069747776,0.0058936574,0.010413103,-0.022546213,-0.041491546,-0.021801198,0.008362185,0.037605036,0.020215558,-0.021526447,-0.05214975,-0.058798462,0.046421707,0.00433572,-0.023521798,0.04102618,0.022497518,0.015019245,-0.054790057,-0.049543418,-0.03762171,-0.02806882,0.025181638,-0.019410474,0.019171052,0.012757266,0.028310034,0.05439817,0.036213256,0.013364224,0.07147108,-0.018827492,-0.03023699,-0.06597303,-0.033951204,0.012014482,-0.038390357,0.060029205,0.028167993,-0.07522317,-0.027382007,-0.062355615,2.7911158e-33,0.015051207,0.019841334,0.050031174,0.033891283,6.480581e-05,-0.0073464937,-0.070601285,-0.029004496,0.006726911,-0.008337915,-0.030017635,-0.03205405,0.045887355,0.0032685008,-0.09580302,9.163965e-05,-0.064646184,0.07241506,0.016579444,-0.049643435,0.07224381,0.17155904,-0.018319294,0.03683264,0.023829307,0.041502096,-0.010357954,-0.009319545,0.028756602,-0.009695111,0.034041706,-0.13057059,-0.020791605,-0.01341803,0.03133654,-0.07109699,0.0068741073,-0.058272198,-0.056181744,-0.028170586,-0.08163333,-0.023897938,-0.07445857,0.0076995087,0.022841865,-0.12634993,-0.041451603,0.10363725,-0.076701865,-0.02273746,0.04550897,-0.033213746,0.032911986,-0.020748286,-0.08907673,-0.04490232,-0.020623857,-0.060820926,0.04955166,0.06256758,0.0760644,-0.02487569,-0.025292076,-0.03176231,-0.015239019,0.025352713,0.04489408,0.0018623262,0.020429868,0.089955404,0.04115698,-0.061803374,0.014139185,0.07253352,-0.004276293,-0.06066484,-0.0056653135,0.052075997,0.005175147,0.04570687,0.079427205,-0.0700994,-0.022638794,0.019154139,-0.07807339,-0.012306953,0.03066076,-0.018951103,0.0021640286,0.08677969,0.023808062,-0.07721627,-0.04126527,0.04053078,0.008357834,-3.0024602e-33,0.06340225,-0.08142887,0.030427936,-0.003384078,-0.03939489,0.007503634,0.07480488,0.03511894,0.03755344,-0.008840456,0.062857695,0.02211101,-0.0031104942,0.0009972904,0.008696513,0.01115315,-0.07272914,0.07774604,-0.019921808,0.096083514,0.0043806206,0.018583182,-0.027673798,0.10466958,0.087021604,0.10421789,-0.018007724,-0.06220723,-0.0317683,0.049480624,0.0059278673,0.024905195,-0.049649056,-0.09323322,-0.053823963,-0.003079791,-0.06280552,-0.054084033,-0.090830736,-0.023502324,-0.07226524,0.07258052,0.044457443,0.0014571813,-0.037955903,0.00049197034,-0.007399736,-0.008261051,-0.020985631,-0.03452462,-0.027271412,0.046309322,0.015244412,-0.014701171,-0.011385688,0.030579906,-0.006865907,0.031465452,0.05324509,0.06260305,0.00892891,-0.112549126,-0.01675039,0.02718716,0.07350769,0.074216336,0.004537455,0.037747495,0.017733796,0.05528142,0.016524263,-0.011461396,0.108395666,0.08622806,-0.039687242,0.04241728,-0.041200504,-0.0016305965,0.028212873,-0.005122712,-0.061784294,-0.0030193767,-0.039754316,-0.051799193,0.020337638,0.0077104177,0.0701925,0.09600997,-0.025913827,0.0562259,0.023872586,-0.04912378,-0.040895328,0.0682735,0.066469334,-3.1110197e-08,0.08260054,-0.06415199,0.07527332,-0.041349273,-0.07406798,-0.030954033,-0.00063596026,0.06759207,0.055421717,0.008484908,0.016703732,0.03168131,0.017051127,-0.00863797,-0.005832052,0.08492694,0.020323874,0.021914124,0.012318467,-0.06955655,-0.03772168,-0.006237655,-0.08036732,0.036189202,0.022514286,-0.028703708,-0.019057957,0.104132675,-0.041214157,-0.017490447,0.048821714,-0.002763392,-0.011929408,-0.05766903,-0.08806458,0.1015357,0.010592417,-0.0020504803,-0.10785412,-0.075826764,-0.03011616,-0.054965626,0.049746387,-0.004545213,-0.012925447,0.03955007,-0.0021959248,-0.0075969137,-0.028576434,-0.028618088,0.05741838,-0.0103054745,-0.02094118,-0.078204826,-0.13846235,0.05928328,-0.024044871,-0.033176728,0.007303676,-0.025936993,-0.039511353,-0.04118069,0.13110921,-0.07532882 +2.6.1.9,A pyridoxal-phosphate protein.,384,0.99999994,-0.027926307,-0.082669966,-0.06864404,-0.0736116,0.027612139,0.00069278304,0.043136388,-0.0022198383,0.07759752,0.061581366,0.050052542,0.024383662,-0.07972978,0.075630225,-0.018062996,0.011146767,-0.058814332,0.026981099,0.028646505,-0.060484987,0.08062581,0.046058796,0.013964545,-0.0034948976,-0.022635197,0.09317548,0.03897881,0.08481283,-0.022757838,-0.06512055,-0.033645604,-0.002438178,-0.04265655,-0.081326276,0.049699727,0.09206192,-0.10426549,0.024624566,0.01641356,-0.038264256,0.09138554,-0.06995117,-0.019178458,0.015225969,-0.079754055,-0.009005391,0.060174454,0.06121611,0.1076781,-0.0044863066,-0.08720911,-0.014019634,-0.013987518,-0.049955927,0.010103739,0.04439458,0.025756652,0.03877331,-0.030249724,-0.031439897,-0.018875996,-0.014899653,0.033183742,0.03005634,0.045147188,-0.03863779,0.011696549,-0.046883464,-0.028674698,-0.0040879943,-0.0399809,-0.0017529497,0.12130531,0.0010538863,-0.034636367,0.09728037,-0.028074443,-0.023704544,-0.04040873,0.055432733,0.03498061,0.00886843,0.038521856,0.08173242,0.056242175,0.02956211,0.015032759,-0.008670652,-0.0671204,-0.03498028,0.0024070852,0.025017837,0.033844747,0.03431295,-0.017365431,0.020294111,0.0095834825,-0.017277373,-0.049156386,-0.05037137,-0.0135520855,0.006560372,0.029906176,-0.04925029,-0.040218767,-0.005961301,-0.070319004,0.04136831,-0.008511003,-0.0040058997,-0.05803713,0.0810462,-0.012979407,0.006107804,0.023426063,0.022639925,0.016739301,-0.004660274,-0.05652102,0.057704583,0.0031750596,-0.032194667,-0.030190036,0.08859248,-0.054773755,-0.0542106,-0.07686096,-2.4678308e-33,0.06313784,0.074121,0.050783433,0.040298108,-0.011358971,-0.014224093,-0.06284932,-0.054584622,-0.06972202,-0.006010194,-0.005837788,-0.041249312,0.07401363,0.007710753,-0.07779482,-0.03148981,-0.09894455,0.03780528,0.09449977,-0.054316152,0.036347546,0.122786574,0.015729465,0.06573166,-0.023447253,0.10535222,-0.04718892,-0.017551308,-0.020911029,-0.010473525,0.017130276,-0.08890346,-0.10486213,-0.037216794,0.029635139,-0.1032107,-0.053137314,-0.088244945,-0.028490026,0.010690034,-0.031340834,-0.06654564,-0.015844474,0.03225437,0.005228752,-0.12502499,-0.022130616,0.049036965,-0.04441586,0.030425001,0.03924025,-0.065284304,0.07721513,-0.0022649365,-0.14055419,-0.054724984,-0.056979842,-0.04121839,-0.0039615375,0.036306877,0.055933136,-0.0074688112,-0.0776967,0.005927369,-0.007340223,-0.05244896,0.01644481,-0.06923204,0.06292541,0.08146769,0.070626065,-0.021183291,0.08123207,0.022367109,-0.017924992,-0.0069551063,-0.03999482,0.04453336,-0.028805178,0.099463925,-0.02261902,-0.0688775,-0.055661384,-0.03151839,-0.050702408,0.0006394455,0.025497343,-0.05753736,0.047344767,0.00027531275,0.030769043,-0.11320937,-0.0680435,0.018650109,-0.030141242,3.6575068e-34,0.07618561,-0.056287874,0.10101466,0.007109189,-0.055663213,-0.0030681002,0.0774277,0.02046836,0.023406582,0.0041982206,0.0350583,-0.0105334455,0.015140504,-0.066251345,-0.004752528,0.054859713,-0.009271968,-0.005652817,0.058509693,0.04026011,-0.003693155,0.011792269,0.016480174,0.09651126,0.053761203,0.075716525,0.01452238,-0.0019530556,-0.07552723,0.029911192,0.030482544,0.07004557,-0.04148779,-0.061042886,-0.052007284,-0.008271353,-0.09736277,-0.01278196,-0.0069765327,-0.020985939,0.016151197,0.05498444,0.06282519,-0.0045872508,0.010520141,0.042866427,0.027957102,0.024932979,-0.0021861685,-0.041766163,-0.009070528,0.099440955,-0.00797877,-0.04209437,0.04130011,0.01732226,-0.047809716,0.014699099,0.035344053,0.037282605,0.0067929225,-0.06915579,0.014899704,0.10745321,0.030028766,0.10507638,0.046958737,-0.016195957,0.036776062,0.07768746,0.059881773,0.040236715,0.05812127,0.105743006,-0.04496424,0.016713494,-0.05329847,0.07651241,0.00803724,0.014868353,-0.019268366,-0.016083399,-0.04608814,-0.091910556,0.043844398,-0.024019118,0.045906533,0.054757874,-0.007998638,-0.026156204,0.031497672,-0.009735406,-0.027109524,0.037469666,0.07564672,-1.9977723e-08,0.09066985,-0.047100395,0.021396253,-0.09606707,-0.0063670287,-0.0071035447,0.06365685,0.0046283896,0.061157417,-0.0008820098,0.024579087,-0.020273905,0.047039416,0.004775769,0.032485493,0.075822994,-0.01940812,-0.021913694,0.019391755,-0.07981513,-0.04740351,0.001936404,-0.10317189,0.00753118,0.07142017,0.010388294,0.004406259,0.008331364,0.0018802646,0.00193429,0.06103492,-0.033622324,-0.007979489,-0.078628175,-0.0016374547,0.089614056,-0.01480436,-0.025552817,-0.07120053,-0.016167747,-0.08352152,-0.0088831885,0.02011399,-0.038908735,-0.0075784125,0.06274982,-0.060978554,0.019942068,-0.035090562,-0.040864546,0.038964637,-0.0051312405,-0.07638949,-0.080362394,-0.15321009,0.04632519,0.039614286,-0.041317645,-0.012306477,-0.087682545,-0.037958488,-0.054651886,0.07941697,-0.07056297 +2.6.1.11,A pyridoxal-phosphate protein. Also acts on L-ornithine and N2-succinyl-L-ornithine.,384,1.0,-0.065999046,-0.06345063,-0.005097699,-0.05670178,0.08900431,0.06428759,0.017511934,-0.0037301094,0.056718897,0.023622118,0.04523719,0.050621938,-0.029119957,0.055864856,-0.0352471,0.10102285,-0.0847565,0.036812667,0.009275998,-0.02964718,0.12899487,0.05579236,0.03839092,-0.041264307,0.04445325,0.06284082,0.010239606,0.06316872,0.038705796,-0.090132505,-0.027436338,-0.03801662,-0.07774684,-0.042910654,0.021910341,0.0547623,-0.08819829,0.021689963,-0.0181569,-0.001778787,0.08485402,-0.10707572,-0.10655285,-0.012976588,-0.029309928,-0.0061236382,-0.028042933,0.05350107,0.050120167,0.008892347,-0.07078014,-0.055117138,0.029411752,0.0108204195,-0.0272856,0.06680657,-0.05838271,0.015487953,-0.026456889,0.0134537965,0.0063593746,-0.016019806,0.02429506,0.04200638,0.11025497,0.00045994364,0.0014465981,-0.032469664,-0.04665408,0.0052123433,0.028144384,-0.014075797,0.07364079,0.024933748,0.033137802,0.024262682,-0.05200208,-0.0072844145,-0.045108747,-0.015908746,0.028344467,0.04299051,-0.0040955753,0.12697975,0.0402123,-0.03464371,0.0035482147,0.051228516,-0.015763573,-0.026994592,-0.032784652,-0.026327686,0.022407785,0.035116658,0.011359434,0.033457816,0.0035034665,0.0012299909,-0.016785631,-0.028884908,-0.05248049,0.011338881,-0.043586608,-0.07161224,-0.06871898,0.0146862,-0.047200885,-0.016594168,0.02140373,-0.011686947,-0.013903801,-0.003322792,0.008211577,0.0019652357,-0.06841142,0.03722891,0.0297649,0.010514526,-0.010875222,-0.034017466,-0.00045388215,-0.04307108,-0.07745685,0.11306887,-0.070377775,0.07262895,-0.103684366,1.2571445e-33,0.096121535,0.0190458,0.03530262,0.060790177,0.016973678,0.021390304,-0.035879347,-0.018879833,-0.0026093244,-0.06634415,0.019917762,-0.075071394,0.065963045,0.0053229113,-0.055540692,-0.061256036,-0.024133964,0.022243736,0.0475986,-0.053261608,0.039845947,0.08915462,-0.09415546,0.07233007,-0.023628777,0.043746803,0.0079874545,-0.02073238,-0.034256056,-0.039475996,0.05065706,-0.09023139,-0.08281468,-0.04488835,0.055140346,-0.062228054,-0.014909322,-0.064034425,-0.028270207,0.0051138587,-0.037677974,-0.004756281,-0.05013344,0.009474188,-0.007892311,-0.075930096,-0.057651106,0.07099574,-0.03106554,0.044735067,0.102546036,-0.082609996,0.026391713,-0.015062083,-0.10579209,-0.00888173,-0.055508435,-0.056373205,-0.007400122,-0.010359918,0.07942905,-0.05632163,-0.00518744,0.0058100787,0.026651997,-0.03610945,-0.033599354,-0.05925854,0.024313126,0.040619243,-0.02885046,0.0007766949,0.10943767,0.041553274,-0.0043338775,0.023768056,-0.09924442,0.041154593,-0.000689806,0.0871773,0.008580519,-0.10279714,0.0017888601,-0.07394826,-0.04776301,-0.04540098,0.0154124135,-0.14599892,0.027643068,-0.03213608,0.05033055,-0.09403368,-0.0502653,-0.019980256,-0.026308503,-2.6550053e-33,0.044132963,-0.07325921,0.09960234,0.041598935,-0.058333833,0.010801993,0.022106549,0.012796193,0.035623018,0.03981505,0.031765174,-0.02973662,0.065883465,-0.07037135,0.046201486,0.032979097,0.001382046,0.0427563,0.041317668,0.07112254,-0.04118024,0.048911497,0.020186052,0.09659221,0.06191552,0.08652982,0.02656847,0.03260228,-0.035031468,0.053257182,0.01926352,0.03647852,-0.041473147,-0.06261728,0.0048692296,0.024728602,-0.015035927,-0.025816856,-0.011624861,-0.06004408,0.010237278,0.025370937,0.08260562,0.013521268,-0.030722974,-0.027498445,-0.012346384,-0.013297759,-0.054106228,-0.07301031,-0.004683539,0.07082937,0.012476841,-0.006984847,0.033376455,0.0559919,-0.073269725,-0.009606673,0.043584365,0.00069405243,0.04777998,-0.048055235,-0.03205871,0.1015971,-0.027250683,0.09692215,-0.028281616,-0.0045930417,0.0631814,0.023545189,-0.02275006,0.022812927,0.08772612,0.07444483,-0.09884285,-0.0059658936,-0.04906368,-0.03062765,-0.0015973774,-0.017028207,-0.054586425,-0.016390055,-0.078125544,-0.084786765,0.02532919,0.0070664817,0.049791187,0.12050017,-0.027108485,-0.0074672303,0.01879842,-0.0003310925,-0.06146811,0.062697,0.07173699,-3.3249137e-08,0.09351068,-0.07368991,0.07005912,-0.04651995,0.0039287014,-0.06650769,0.0608941,-0.009723472,0.05511298,-0.010218289,-0.00047729915,0.02761064,0.016876403,-0.044189516,0.10363925,0.03578643,0.068819135,0.05542417,-0.029750282,-0.04536619,-0.032006238,-0.0054864273,-0.06025359,0.044897933,0.03594232,-0.029174827,0.033203665,0.05829684,0.09970274,-0.071646616,0.036148272,-0.0139558315,0.0109923035,-0.084080644,-0.004864044,0.104950026,-0.02836606,-0.07271237,0.022469833,0.0052031185,-0.05098496,0.015978033,0.0339975,0.0027173748,-0.04291221,0.012028616,-0.0351818,-0.015904795,-0.038523804,-0.00456352,0.03663849,-0.040779237,-0.043848123,-0.062258847,-0.14887626,0.04432691,0.0063304985,0.021714887,0.0092205405,-0.07476972,-0.050866395,-0.0068297465,0.12941678,-0.028543036 +2.6.1.12,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.13,A pyridoxal-phosphate protein.,384,0.99999994,-0.027926307,-0.082669966,-0.06864404,-0.0736116,0.027612139,0.00069278304,0.043136388,-0.0022198383,0.07759752,0.061581366,0.050052542,0.024383662,-0.07972978,0.075630225,-0.018062996,0.011146767,-0.058814332,0.026981099,0.028646505,-0.060484987,0.08062581,0.046058796,0.013964545,-0.0034948976,-0.022635197,0.09317548,0.03897881,0.08481283,-0.022757838,-0.06512055,-0.033645604,-0.002438178,-0.04265655,-0.081326276,0.049699727,0.09206192,-0.10426549,0.024624566,0.01641356,-0.038264256,0.09138554,-0.06995117,-0.019178458,0.015225969,-0.079754055,-0.009005391,0.060174454,0.06121611,0.1076781,-0.0044863066,-0.08720911,-0.014019634,-0.013987518,-0.049955927,0.010103739,0.04439458,0.025756652,0.03877331,-0.030249724,-0.031439897,-0.018875996,-0.014899653,0.033183742,0.03005634,0.045147188,-0.03863779,0.011696549,-0.046883464,-0.028674698,-0.0040879943,-0.0399809,-0.0017529497,0.12130531,0.0010538863,-0.034636367,0.09728037,-0.028074443,-0.023704544,-0.04040873,0.055432733,0.03498061,0.00886843,0.038521856,0.08173242,0.056242175,0.02956211,0.015032759,-0.008670652,-0.0671204,-0.03498028,0.0024070852,0.025017837,0.033844747,0.03431295,-0.017365431,0.020294111,0.0095834825,-0.017277373,-0.049156386,-0.05037137,-0.0135520855,0.006560372,0.029906176,-0.04925029,-0.040218767,-0.005961301,-0.070319004,0.04136831,-0.008511003,-0.0040058997,-0.05803713,0.0810462,-0.012979407,0.006107804,0.023426063,0.022639925,0.016739301,-0.004660274,-0.05652102,0.057704583,0.0031750596,-0.032194667,-0.030190036,0.08859248,-0.054773755,-0.0542106,-0.07686096,-2.4678308e-33,0.06313784,0.074121,0.050783433,0.040298108,-0.011358971,-0.014224093,-0.06284932,-0.054584622,-0.06972202,-0.006010194,-0.005837788,-0.041249312,0.07401363,0.007710753,-0.07779482,-0.03148981,-0.09894455,0.03780528,0.09449977,-0.054316152,0.036347546,0.122786574,0.015729465,0.06573166,-0.023447253,0.10535222,-0.04718892,-0.017551308,-0.020911029,-0.010473525,0.017130276,-0.08890346,-0.10486213,-0.037216794,0.029635139,-0.1032107,-0.053137314,-0.088244945,-0.028490026,0.010690034,-0.031340834,-0.06654564,-0.015844474,0.03225437,0.005228752,-0.12502499,-0.022130616,0.049036965,-0.04441586,0.030425001,0.03924025,-0.065284304,0.07721513,-0.0022649365,-0.14055419,-0.054724984,-0.056979842,-0.04121839,-0.0039615375,0.036306877,0.055933136,-0.0074688112,-0.0776967,0.005927369,-0.007340223,-0.05244896,0.01644481,-0.06923204,0.06292541,0.08146769,0.070626065,-0.021183291,0.08123207,0.022367109,-0.017924992,-0.0069551063,-0.03999482,0.04453336,-0.028805178,0.099463925,-0.02261902,-0.0688775,-0.055661384,-0.03151839,-0.050702408,0.0006394455,0.025497343,-0.05753736,0.047344767,0.00027531275,0.030769043,-0.11320937,-0.0680435,0.018650109,-0.030141242,3.6575068e-34,0.07618561,-0.056287874,0.10101466,0.007109189,-0.055663213,-0.0030681002,0.0774277,0.02046836,0.023406582,0.0041982206,0.0350583,-0.0105334455,0.015140504,-0.066251345,-0.004752528,0.054859713,-0.009271968,-0.005652817,0.058509693,0.04026011,-0.003693155,0.011792269,0.016480174,0.09651126,0.053761203,0.075716525,0.01452238,-0.0019530556,-0.07552723,0.029911192,0.030482544,0.07004557,-0.04148779,-0.061042886,-0.052007284,-0.008271353,-0.09736277,-0.01278196,-0.0069765327,-0.020985939,0.016151197,0.05498444,0.06282519,-0.0045872508,0.010520141,0.042866427,0.027957102,0.024932979,-0.0021861685,-0.041766163,-0.009070528,0.099440955,-0.00797877,-0.04209437,0.04130011,0.01732226,-0.047809716,0.014699099,0.035344053,0.037282605,0.0067929225,-0.06915579,0.014899704,0.10745321,0.030028766,0.10507638,0.046958737,-0.016195957,0.036776062,0.07768746,0.059881773,0.040236715,0.05812127,0.105743006,-0.04496424,0.016713494,-0.05329847,0.07651241,0.00803724,0.014868353,-0.019268366,-0.016083399,-0.04608814,-0.091910556,0.043844398,-0.024019118,0.045906533,0.054757874,-0.007998638,-0.026156204,0.031497672,-0.009735406,-0.027109524,0.037469666,0.07564672,-1.9977723e-08,0.09066985,-0.047100395,0.021396253,-0.09606707,-0.0063670287,-0.0071035447,0.06365685,0.0046283896,0.061157417,-0.0008820098,0.024579087,-0.020273905,0.047039416,0.004775769,0.032485493,0.075822994,-0.01940812,-0.021913694,0.019391755,-0.07981513,-0.04740351,0.001936404,-0.10317189,0.00753118,0.07142017,0.010388294,0.004406259,0.008331364,0.0018802646,0.00193429,0.06103492,-0.033622324,-0.007979489,-0.078628175,-0.0016374547,0.089614056,-0.01480436,-0.025552817,-0.07120053,-0.016167747,-0.08352152,-0.0088831885,0.02011399,-0.038908735,-0.0075784125,0.06274982,-0.060978554,0.019942068,-0.035090562,-0.040864546,0.038964637,-0.0051312405,-0.07638949,-0.080362394,-0.15321009,0.04632519,0.039614286,-0.041317645,-0.012306477,-0.087682545,-0.037958488,-0.054651886,0.07941697,-0.07056297 +2.6.1.14,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.15,A pyridoxal-phosphate protein. L-Methionine can act as donor; glyoxylate can act as 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+2.6.1.16,"Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination).",384,1.0,-0.010499994,-0.04332946,-0.022668753,-0.02880712,0.059796583,0.06852508,0.008301534,0.017306143,0.058822036,0.06487718,-0.021885198,-0.03139387,-0.039795935,-0.0014767676,-0.08757117,0.00446633,-0.11503739,0.008458122,-0.046562526,-0.057794813,0.07051299,9.76506e-05,-0.022277413,-0.044210646,0.05347455,0.014958171,0.017952472,-0.06377968,0.03351181,-0.04528558,-0.10210579,-0.029190412,-0.05526504,-0.0007173531,-0.016227262,0.11489719,-0.039914694,-0.009827315,-0.004613468,0.0015546009,0.03890944,-0.05030128,-0.0074180085,-0.08781042,-0.037659656,0.03151142,0.03557117,0.05547214,-0.0015011096,-0.017730627,0.00035182564,-0.07744685,-0.01566321,0.08656349,-0.025108378,0.04621194,-0.032738123,-0.02494304,-0.001083242,0.034060583,-0.06676282,0.061322577,0.016923098,-0.020063926,0.1078105,-0.09463524,-0.011685476,-0.020595014,-0.029801281,-0.070782125,-0.022744361,-0.052257996,-0.061632633,-0.036532536,0.05786232,-0.09198218,-0.066940814,0.05254549,0.015391428,0.04047069,0.054134022,-0.021166945,0.023561446,-0.017563624,0.020531543,-0.0063284747,-0.014263949,-0.015187849,0.05492433,0.012394285,-0.020790618,-0.054007158,-0.010866935,-0.05147177,-0.0693315,-0.035864517,-0.016400987,0.028613402,0.13919763,-0.0020238138,0.03072309,0.08018702,-0.07051954,-0.030098384,-0.052541453,0.009690536,0.0039465227,0.12726618,-0.041007556,-0.0012440942,0.002145965,0.022982845,0.073319055,0.052882005,0.0019333571,0.059287373,-0.031854212,-0.07817406,-0.086467914,-0.032223653,0.028703557,0.07844117,0.005501848,0.116384685,-0.047257066,0.09535135,-0.09475183,-3.064897e-34,0.051985808,0.047380533,0.017817153,-0.033042155,-0.026873771,0.00015542778,-0.054560497,0.0152585665,0.034596585,-0.03210589,-0.07225473,-0.020923294,0.09754013,-0.036486067,-0.035412755,-0.022297096,-0.01700709,0.022463217,0.0784508,0.011030342,0.042768925,0.063553244,-0.029120164,0.0378554,-0.08299614,0.06688067,-0.085134104,0.022557078,0.020369103,-0.02519005,-0.014057522,-0.048813533,-0.10482569,-0.022994364,0.035918217,-0.031915765,-0.04023269,-0.020299068,0.009577712,0.03241292,0.01337581,-0.021996817,-0.09055257,-0.011221531,0.060432408,-0.00042350506,-0.024226021,0.051658686,0.039950974,0.054563414,0.01891533,-0.077868395,0.0619932,-0.04485823,-0.031750113,0.016688995,0.032756,-0.08446932,0.0015651779,0.06192904,-0.02420983,0.04995963,-0.012125769,0.030269744,-0.009613657,-0.018918056,-0.03550593,-0.032612693,-0.0037324661,0.0715398,-0.13230862,0.0203006,0.04906732,0.043802354,0.0418052,-0.066475354,-0.12173551,-0.028003301,-0.032250036,0.014125406,0.06142024,-0.007859793,-0.012814632,-0.031694908,-0.029311204,-0.056471866,-0.076758325,-0.09830843,-0.04297628,0.04977052,0.09134005,-0.06860669,-0.07428575,0.053857412,0.09401652,-2.1083863e-33,0.15259992,-0.09909491,0.037209645,-0.039778218,-0.045429904,-0.020401232,0.06430352,0.013001892,0.038889624,-0.008139621,-0.002102039,-0.005962483,0.018631736,0.055061698,-0.021732863,-0.051527586,0.05265347,0.0849678,0.050656103,-0.043683495,0.029387044,0.038412474,-0.040629152,0.018536078,0.05602212,0.015373313,-0.03232804,0.06725279,0.0616185,0.015870707,-0.0022523792,-0.1014138,0.010183222,-0.04781375,-0.015939247,0.032463886,0.015491686,0.005392062,0.010076292,0.015570142,0.040165763,0.002012708,0.056296185,0.08812763,0.029694628,0.068981074,-0.0757059,-0.027324151,-0.013544308,-0.017921487,0.05291386,0.018513616,-0.035410784,-0.061922662,0.02377486,-0.0037290633,0.065709196,0.0042333636,-0.015909059,-0.0035377878,0.0051145903,-0.06784778,-0.015082439,-0.07116876,0.017884921,0.018000882,0.02980027,0.064308174,0.07343232,-0.0052070217,0.035396386,0.0074049914,0.07881697,-0.027476138,-0.016082397,-0.06989183,-0.03320611,-0.040063456,0.05109612,-0.0549081,-0.082528874,-0.017832205,0.049342778,-0.05571845,0.029412322,-0.05046322,0.037173864,0.06642781,-0.014880709,-0.016803699,-0.019462187,-0.027019098,0.062637456,-0.009570338,0.045716573,-3.6202035e-08,0.035441935,-0.11242681,-0.006761366,0.016827729,0.02806934,0.09598267,0.0065975077,0.05487746,-0.020985583,-0.06797238,-0.08301342,0.12983808,0.03933113,-0.024295727,0.04364827,0.028971458,-0.029753951,-0.014849083,-0.028104404,-0.11039809,-0.05893926,-0.019341156,-0.06360271,0.096726954,0.0034595546,-0.038349394,0.039269187,0.07881891,-0.008666845,-0.068447106,0.015019847,0.0046091788,0.026941733,0.0014212418,0.0006952106,0.06844039,0.013016519,-0.007872066,0.019854741,-0.06521157,-0.02481864,0.048198245,-0.10619288,-0.009857488,0.00905219,0.08099354,0.00019235516,0.0112056965,-0.021891987,0.017666366,0.0611271,-0.028376859,0.0094542075,0.021302689,-0.026672216,-0.034004208,-0.018659767,-0.09735982,0.027736446,0.020727282,0.05034884,0.08726822,0.17648517,-0.03694608 +2.6.1.17,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.18,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.19,"Requires pyridoxal phosphate. Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate. cf. EC 2.6.1.120, beta-alanine---2-oxoglutarate transaminase.",384,1.0,-0.0010828051,-0.09746563,-0.06551153,-0.055777267,0.007620058,0.051213592,0.01922873,0.031756755,0.002972825,0.09732108,0.008740981,0.00665035,-0.11022129,0.13496184,-0.009826698,-0.0045619947,-0.078308,0.0049928585,0.017049212,-0.047759943,0.10820238,0.04362329,-0.0034586333,-0.008749481,0.029780516,0.04531513,0.018839931,-0.007599872,0.057992075,-0.023690281,-0.060152717,-0.058942016,-0.012460337,-0.10759206,0.025674885,0.08858163,-0.10892868,-0.03965529,0.006623032,0.039050654,0.06709229,-0.09243091,-0.025064968,-0.022998191,0.016758272,-0.04468296,0.060555987,-0.021629982,0.04093192,0.001271695,-0.051932897,-0.068700075,-0.005167287,-0.012264762,-0.004047569,0.02419441,-0.024974022,-0.0012976356,-0.03971328,-0.0037710338,-0.032796063,-0.02378386,-0.01614011,-0.02859463,-0.0131304115,-0.012470649,-0.007423638,-0.02458847,0.02964051,-0.009012851,-0.07878355,-0.09046556,-0.0012323145,0.03637772,-0.07971727,0.002243584,0.03077232,-0.0395067,-0.015999272,0.0065775677,0.0036609939,-0.025005747,0.013672582,0.05861855,0.06811273,0.086774975,-0.0025973613,0.016461287,-0.05031813,0.025030266,0.053171143,-0.0001894929,0.027812256,-0.0108539555,0.014816096,0.011545243,-0.038697027,0.011151998,0.0084024295,-0.038433377,-0.009096483,0.03753751,-0.02193182,0.0075953123,-0.08304592,0.014818788,-0.066645324,0.030734522,-0.0109263025,0.0022017355,-0.047145512,0.027516311,0.010613796,0.04392204,0.0032312644,0.08896463,0.022879725,-0.040657785,-0.03705308,0.026253296,0.0001567378,-0.012862186,0.06620955,0.068061516,-0.046379227,0.00402848,-0.045660257,-6.024295e-35,0.09264492,0.100449674,0.027157584,0.06771276,-0.030298766,0.07840933,-0.09415702,-0.011313306,0.04299416,-0.06346773,-0.06563088,-0.03615533,0.048425928,-0.00087845215,-0.01573226,0.01788669,-0.0073605212,0.018023217,0.09374645,-0.026547523,0.034060672,0.06473615,-0.023960216,0.023980822,-0.004202385,0.047030747,0.0032203454,-0.03598104,0.028481994,-0.010191005,0.023176624,-0.08330211,-0.06067948,-0.04394768,0.00030152212,0.0126900105,-0.065380044,-0.04284591,-0.017085562,0.07572515,0.082530156,-0.01333797,0.0014180614,0.054051246,0.08660379,-0.0792668,-0.011203326,0.10166565,-0.0028221025,0.09858671,0.04904168,0.00879824,0.040660407,-0.03765124,-0.057086434,-0.004664187,-0.060475327,-0.049836848,0.042527936,0.045805544,0.026968444,-0.013368096,-0.0076464997,-0.0009362542,-0.014592074,0.022406712,-0.027580531,-0.08831306,-0.07462175,-0.021407831,-0.041679833,-0.03989267,0.06664913,0.06012646,0.0046336167,-0.044634793,-0.02989396,0.064912245,0.0058302665,-0.041761786,-0.018443115,-0.03320086,-0.023498047,0.028801821,-0.011419691,-0.046921726,0.060388345,-0.034166798,0.0010209515,0.0049847667,0.054366227,-0.09659172,-0.10306472,0.043791912,0.03624546,-3.8364125e-34,0.09320887,-0.12390792,0.006375354,-0.05879948,0.00047220933,-0.00015279745,0.11286146,-0.10099877,0.043568704,-0.020204106,0.060775764,-0.008337572,0.0062550833,-0.088308066,-0.0401083,-0.058567047,-0.020039598,0.08704022,0.04973188,-0.0029445593,0.050467614,0.0731529,0.0632082,0.083437555,0.08580006,0.04229194,0.02601147,-0.010946178,0.024848808,0.023607133,-0.014659616,-0.00344478,-0.02496721,-0.060013816,-0.1057151,0.072168924,-0.015229611,0.033385325,-0.022600077,0.040911302,0.015926927,0.05422945,0.010520861,0.08337659,-0.018517762,0.042764783,-0.017904967,-0.024734732,-0.023731109,-0.058030844,0.056236155,-0.036566973,-0.014541743,0.017709062,0.08344548,0.025777474,-0.05890975,0.048288215,-0.00096855755,-0.012851869,0.022022879,-0.014981491,0.032920167,-0.068288945,0.04991464,0.014981052,0.01407553,0.054928765,0.016899992,0.048933942,0.031552147,0.0033919453,0.10826688,0.023622157,-0.020865245,-0.020876832,-0.07044573,-0.044003874,0.0312619,-0.08848097,-0.08072271,-0.010205655,-0.01386797,-0.028625628,0.041887786,-0.05193967,0.076605015,0.052978594,-0.014383027,0.00339619,-0.014342592,0.008587544,-0.0007811193,0.12177988,0.1094492,-4.466523e-08,0.05590473,0.0052491706,0.023509322,-0.063719824,0.011786891,0.013728993,0.0753377,-0.00137076,0.0143785635,-0.066649444,-0.07043076,0.047296055,0.069128774,0.04292881,0.056074902,0.04501704,-0.041247066,0.080628425,-0.04387421,-0.08947739,-0.11998446,-0.007019608,-0.08732172,0.022815445,0.026788268,-0.03735988,0.073492676,0.03511574,-0.009573635,0.01743704,0.035822645,-0.005237457,0.02808244,-0.08747961,-0.09291377,0.07774113,0.028814968,0.016449783,-0.049528517,-0.063378245,-0.07863069,-0.05805299,-0.028633753,0.02717073,0.024458207,0.016701564,-0.060914047,0.07829806,-0.017452624,-0.07073067,0.105909914,-0.033507153,-0.055487785,-0.07447345,-0.1260855,0.06346059,0.0024756566,-0.05067697,0.04987048,-0.07615415,0.012162222,0.017569805,0.16072595,-0.092528634 +2.6.1.21,"A pyridoxal-phosphate protein. The enzyme from thermophilic Bacillus species acts on many D-amino acids with D-alanine and D-2-aminobutyrate as the best amino donors. It can similarly use any of several 2-oxo acids as amino acceptor, with 2-oxoglutarate and 2-oxobutyrate among the best. The enzyme from some other sources has a broader specificity [6].",384,0.99999994,-0.058126133,-0.09347255,-0.022262773,-0.10861223,0.024131272,0.017430041,-0.0052373665,0.036076546,0.05710662,0.027841864,0.008897616,-0.034221537,-0.036606964,0.12789656,0.022183327,0.08606167,-0.032406114,0.024571093,-0.003061465,-0.024640061,0.07892929,0.05676043,-0.0028644993,-0.03429684,0.016161483,0.022139648,0.0815039,0.00052393833,-0.049965665,-0.027058402,-0.04928444,-0.079768576,0.006635353,-0.046592016,0.02712885,0.046402942,-0.05323134,0.021849623,0.031720404,0.00895535,0.03835027,0.025537184,0.032436285,-0.028622469,-0.11245183,0.0054121623,0.093171634,0.024652233,0.08165064,-0.02884645,-0.06449023,-0.028379919,-0.026169647,0.005385262,0.00816417,0.055796493,-0.011611736,-0.018691184,-0.04005818,-0.063955985,0.00025198574,0.004405762,0.06121502,0.013362051,0.05425929,-0.047410756,-0.0015860185,-0.05898133,-0.05654871,-0.08075705,-0.06875588,-0.0458084,0.0849521,0.042409997,0.05842425,0.016582292,-0.04940871,-0.043948747,0.043734726,-0.052862827,0.031258866,-0.023845898,-2.4147423e-05,0.10987581,0.04893999,0.043438334,0.023400286,0.0012536468,0.029097695,-0.0026369824,0.001551557,0.012118692,0.039808318,-0.042300105,-0.025802488,-0.005927334,-0.009913822,0.028241824,-0.018021904,-0.023975303,-0.042609256,0.04631181,-0.03264167,-0.046756648,-0.077568054,-0.038933937,-0.056172702,-0.0010371283,0.058446467,-0.024547553,0.0065051834,0.053947266,0.03799984,0.002555746,-0.01771871,0.021953505,0.020290928,-0.023872945,-0.08383558,-0.042319708,-0.005986098,-0.019817721,0.078741945,0.08083429,-0.03077664,0.015310049,-0.073820956,3.556257e-33,0.015787158,0.029620355,0.042153414,0.02112667,0.005756581,-0.04048913,-0.093708076,-0.034885813,0.0012811816,-0.05152999,-0.114618555,-0.082390584,0.06146011,0.08445373,-0.017438235,0.03153487,-0.036625616,0.062145744,0.047957573,0.014300644,0.057978153,0.101726875,0.04302534,0.08382031,0.06369673,0.04140507,0.040344205,0.039539617,0.052792862,-0.00041172974,0.016552964,-0.09469797,-0.12547643,-0.041338824,-0.010564833,-0.075598896,-0.11208329,-0.014869773,-0.026794937,0.04038627,-0.021725556,-0.00026807713,-0.021078737,0.04990558,0.040701665,-0.026186103,-0.015344984,0.07314811,-0.057753343,0.053849086,0.04709808,-0.069608115,0.04149234,-0.03950911,-0.09016998,-0.03976216,-0.013106966,0.026730515,0.040605336,0.08027051,0.026648115,0.023987118,-0.030669827,0.021217978,-0.05352214,-0.020720003,0.02850653,-0.095716,0.017698664,0.04483515,-0.015317775,0.038598265,0.037987396,0.021675274,-0.028195968,-0.088515684,0.002815192,-0.027491475,0.04347821,-0.011129998,0.010873061,-0.060580656,0.0054626493,-0.042732008,-0.058865976,-0.045256667,-0.004948668,-0.08849566,-0.008255212,0.026281368,0.0039908597,-0.10769105,-0.0892011,0.03617333,0.044840023,-3.7823786e-33,0.097631104,-0.10658308,0.08517574,-0.032483757,-0.029584682,0.0047705774,0.10660425,-0.0042537604,0.057862543,-0.069120176,0.042293362,0.010528029,0.050206568,-0.0039255014,0.06422468,0.02981099,-0.042104255,0.009803686,0.038109332,-0.016478084,0.031494033,0.060034305,0.021556625,-0.05218424,0.0489421,0.055112332,-0.04912494,0.083421536,0.020148901,-0.0319947,0.003580718,0.06584973,-0.020533767,-0.0695355,-0.080574915,0.09391813,-0.036117505,-0.015919715,0.014437789,0.04930543,-0.018322384,0.06122692,0.018683003,0.024570411,-0.0328162,0.050556492,-0.022336481,-0.051806677,0.06434994,-0.04927872,0.033119738,-0.0026052122,0.029276276,-0.040381085,0.073036365,0.02820577,-0.05377699,0.05488138,-0.017198619,-0.028535185,-0.06629182,-0.1024302,0.10699527,0.10047499,-0.030146813,0.07974466,0.030099431,0.0116914855,-0.0050359555,0.029211486,0.09812882,-0.021764502,0.052022804,0.069480255,-0.025493523,-0.006951559,-0.06206093,0.06815621,0.045977954,0.033168342,-0.08542599,-0.01012601,-0.019164637,0.018361965,0.07289431,-0.072303094,0.08018118,0.04971012,0.011403201,-0.002250278,-0.015713569,-0.014054807,0.058237452,0.05672912,0.11282384,-4.5094456e-08,0.069659054,-0.07801486,0.0275527,-0.016693972,0.034365654,-0.033125047,-0.054317534,0.024076598,0.036433455,-0.06940798,0.010583622,0.07572596,-0.03927975,0.049255732,0.025658615,0.03498158,-0.083232455,-0.02853243,-0.018426353,-0.06956573,-0.0752066,0.015615904,-0.11960613,-0.024743445,0.025492784,0.0074580032,-0.00058202166,-0.027171988,-0.03547154,-0.009386237,-0.006759133,-0.036455248,-0.05723635,-0.1188866,-0.028341139,0.022966688,-0.083871655,0.020927276,0.0005751488,0.010592857,0.056112256,-0.054547988,-0.03392772,0.020589588,0.0287987,0.05607138,-0.114071615,0.017020568,-0.050982967,-0.0023846333,0.07670283,-0.022071784,-0.039395988,-0.039797697,-0.17048968,0.058059394,-0.010070698,-0.047130022,0.00173833,-0.02913377,-0.018390635,0.012158507,0.095969714,-0.027884215 +2.6.1.22,"Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, (R)-3-amino-2-methylpropionate---pyruvate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.",384,1.0,-0.023288537,-0.068436615,-0.085162856,-0.027127808,0.11045458,0.05997091,-0.06609122,0.04958815,-0.003940879,0.014535051,0.028746506,-0.08525537,-0.07426956,0.007332285,0.061155953,0.10378299,-0.13858424,-0.02310739,-0.0048768674,-0.04621119,0.048346628,0.0024145336,0.0066911844,0.028699847,0.053531293,0.04220988,0.03247125,0.06289046,0.033451416,-0.041454542,-0.019719576,-0.10973407,-0.037166886,-0.0027706397,0.03455594,0.06588909,-0.062422607,-0.05114751,0.0010727542,0.005722449,0.09417186,0.020021226,-0.041537516,-0.047647726,-0.0130707715,-0.052093532,-0.024784248,0.048757643,0.0017302731,0.0027110688,-0.017015602,-0.1061882,-0.033077214,-0.011094332,-0.029824184,0.07237765,-0.0116752805,-0.0042643347,-0.0419293,0.028550534,0.06305195,-0.0021552404,-0.021867597,0.00934354,-0.0060427017,-0.035998013,0.060199395,-0.076365784,-0.029233662,0.011235192,-0.10422646,-0.10503305,-0.023575993,0.03043045,0.0026923583,-0.016830696,-0.027462179,-0.016070906,-0.023972603,-0.045660403,0.027169144,0.016453888,-0.049576223,-0.00055192277,0.028292706,-0.029249689,0.008245328,-0.023644162,0.0077188136,0.07642108,0.03789091,-0.02479397,0.03570328,-0.008727363,0.00820097,0.052007727,-0.0009862869,0.050342105,0.018436799,0.0098086195,0.02154129,0.06749448,-0.04524766,-0.06010551,-0.0046151434,0.035900947,-0.0067198155,0.116159074,-0.029214652,0.0053239246,-0.024479913,-0.01661339,0.10521959,0.052778143,-0.026688773,0.13873409,0.029110994,-0.01867656,0.06635015,-0.012083282,0.048626963,-0.012430432,0.09057742,0.03003738,-0.070482306,-0.010409841,-0.07785388,7.559372e-34,0.093152516,-0.033503193,0.051545095,0.026079398,0.001886929,0.025220934,-0.1219024,0.044775788,0.015668862,0.010683297,-0.10666799,-0.0034183618,0.076320074,0.027698625,-0.008155866,-0.034536846,-0.039130364,0.11147876,0.024637539,0.0055363644,0.009005951,0.04107467,-0.015251244,0.010695016,-0.035116173,0.018870058,0.016221398,-0.0005747679,0.08924921,-0.025426315,0.029183784,-0.03451817,-0.1275208,0.0061116023,0.051957946,0.00520018,0.0065746144,-0.018799296,0.03676328,0.08100836,0.067161694,0.01792672,-0.0043465868,-0.00989732,0.032607313,-0.03802382,0.025074236,0.07560925,0.07315142,0.010205516,0.060522467,-0.040804114,0.06190718,-0.0034850745,0.01584728,-0.0014205159,-0.018523166,0.03438189,0.023827368,0.01612114,-0.026567072,0.012505619,0.0631455,-0.023637882,-0.005573615,0.011961965,-0.11150166,-0.07953538,-0.07745267,-0.0005920713,-0.07045635,0.014696894,0.07131192,0.053742893,0.028077452,-0.09854634,-0.13774368,-0.013249408,-0.05463618,-0.017391363,-0.034991167,0.0010745957,0.0045360546,0.0031613312,-0.04299173,-0.024129719,0.020672655,-0.050716657,0.04249669,0.029300528,0.027449852,0.008868485,-0.06340394,0.04840983,0.03422943,-1.1529304e-33,0.062485196,-0.12288934,0.022238635,-0.03098882,-0.050558303,0.03825451,0.030815147,-0.011728219,-0.030859156,0.0091130445,0.10846537,0.03778703,0.08744191,-0.08191402,0.0614272,-0.059058093,-0.006226897,0.084267534,0.023914937,-0.040450264,0.061896365,-0.0048671844,0.01788882,0.015053401,0.06773409,0.049792614,-0.018162867,0.025546202,0.06290138,0.033872075,-0.056183793,-0.0006246671,-0.022773325,0.027402189,-0.078408994,0.08662367,-0.031231916,-0.008073831,-0.031139817,0.05647991,-0.060052983,0.050517153,-0.017174471,0.058460098,0.020774867,0.022940138,-0.04466383,-0.03199697,-0.07003634,-0.040528923,0.03950422,-0.03996264,-0.06071454,0.0009673399,0.03030995,0.030735515,-0.042481974,0.031156957,0.009281876,-0.015663538,-0.015077712,-0.0070074205,-0.0014028336,-0.09809426,0.062167376,0.005916979,-0.0046337065,0.02083433,0.05359882,0.009842695,0.03667582,-0.011393085,0.0062512825,0.020171668,0.03680253,-0.055147108,-0.008014956,-0.12361563,-0.03976763,-0.116241746,-0.07515452,-0.0014235752,0.036143698,-0.044618964,-0.062308934,-0.05418102,0.04065522,0.11601215,-0.03358953,0.042199075,-0.019326389,0.018372362,-0.04957242,0.1474278,0.088469274,-4.22575e-08,0.06315417,-0.056393374,0.045221042,-0.016193226,-0.049598258,0.015530577,0.053787123,0.005550769,0.04682352,-0.07320792,0.008697176,0.047203433,0.0538633,0.045904536,0.06318192,-0.005604089,-0.016876,0.096554674,-0.038138654,-0.038219582,-0.103951365,-0.039833933,-0.07277335,0.0035651028,0.04894197,-0.04839325,-0.002760452,0.107661285,-0.03185213,0.022106672,-0.0053453017,-0.0029195424,0.052381035,-0.026694002,-0.05168321,0.06584276,-0.08845206,0.015014427,-0.054183207,-0.027686922,-0.011655879,-0.0773051,-0.1290984,0.03631399,0.04227583,-0.008688066,0.0062636263,0.077083975,-0.00086979877,-0.0218313,0.03948642,-0.012604093,-0.003154635,-0.05181403,-0.10324748,0.016814647,-0.075149976,-0.018066254,0.03325001,-0.03162987,-0.00589791,0.017783511,0.1200174,-0.07879587 +2.6.1.23,"The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.",384,0.99999994,-0.060365826,-0.066692375,-0.012033011,0.009572744,0.054686885,-0.0088381125,-0.12093529,0.12758903,-0.017923696,-0.032721765,0.014017294,0.08539999,-0.08456804,0.028406853,-0.057988483,0.04351738,-0.09959273,-0.020485776,-0.04881281,-0.051055156,0.064016655,-0.020327246,0.0010101409,-0.0018898345,0.065426275,-0.055136986,0.039571244,-0.0068574804,0.011549488,-0.08356865,0.006963862,-0.07157633,-0.032599926,-0.0005727827,0.058715038,0.035416752,0.0024933952,-0.08618613,0.0010187667,0.016043512,0.051195547,-0.03608802,-0.08686127,-0.07679006,0.12589502,-0.05407413,0.02117849,-0.0049077864,0.0280479,0.09263618,-0.020589635,-0.0675018,-0.014280394,0.022637324,-0.038056627,0.054402824,-0.049275674,-0.003480953,-0.03725768,0.02901531,0.03372854,0.017764965,-0.027281685,-0.013668512,0.048866086,-0.03165926,0.035761937,0.0060147154,-0.021983948,0.01364051,-0.080616094,-0.06428891,0.08729959,0.04732799,0.033557035,-0.013765765,-0.054737248,-0.028605364,-0.0075806994,0.0005005823,0.059260957,-0.029748874,-0.013438466,0.036650345,0.009016595,-0.024355277,0.05288163,-0.08007678,-0.008600717,0.04350728,-0.012956422,0.018769525,0.017753454,0.020505225,-0.06366509,0.07242884,-0.012553744,0.06363513,0.050357617,0.0018911803,-0.0053633843,0.054480672,0.019597523,-0.07118484,-0.022365069,0.007618505,-0.0047967304,0.11918318,0.08464785,0.025340153,0.061888628,-0.028416451,-0.0007522244,0.042314015,-0.010917832,0.088635094,-0.04333258,-0.032215882,-0.010294992,-0.0073340894,0.006217642,-0.012947389,0.10742697,0.00017303857,-0.0707257,0.05197098,-0.02282536,-2.9626136e-34,0.04266115,0.03382289,-0.007868478,0.01086889,-0.034847774,-0.0024583037,-0.15791322,0.027406087,-0.06601985,-0.08618942,-0.07375818,-0.030301444,0.06316543,-0.01908779,0.017696839,-0.054792456,0.005718903,0.0018950131,0.069193766,0.020081181,0.0663474,0.012676772,-0.0110065555,0.035992272,0.018582765,0.00819635,0.01311852,0.027246116,-0.034708396,0.0024026143,0.009510875,-0.086916134,-0.013447348,0.0023450465,0.027299408,-0.017610144,-0.037389334,-0.078095704,-0.013993619,0.061576717,0.026390767,-0.011395855,0.07986584,-0.043955587,0.075919114,-0.10542112,0.017534709,0.10825123,-0.013646783,0.040552936,0.02266023,0.01355452,0.057441026,-0.04616271,-0.007415676,0.0030360078,-0.07287294,0.023171509,0.060667314,0.019499179,0.051599994,0.01743016,-0.039942283,0.018254202,-0.018330613,0.05752176,-0.0696137,0.032953884,-0.07309079,0.0478179,-0.09923304,0.0056901476,0.060714956,0.043762986,0.019943276,-0.055927265,-0.05289017,0.10339618,-0.016651247,-0.04698254,-0.06725134,0.031075623,-0.048195414,0.03207347,-0.0042813425,0.014715613,0.06942376,-0.022511749,0.06359973,0.06654638,0.07462067,-0.050199956,-0.10567431,0.035536364,0.049938228,-2.403059e-34,0.055441946,-0.08455444,0.02161223,-0.057720102,-0.034682684,-0.0014327597,0.060897704,0.037807204,0.004875839,0.0060876207,0.11261646,0.009867931,0.0028380633,-0.1039214,0.044929367,0.0077877305,-0.06659729,-0.0066523147,0.007885973,-0.009244894,0.08570905,0.08892843,0.01031583,0.015282092,0.042072907,0.020413505,0.006652428,0.0064800307,0.06655803,0.06462728,-0.02036235,0.0025230593,0.010181454,0.008516304,-0.062280573,0.079746805,-0.017768843,-0.006147035,0.019111397,-0.010656629,0.007789046,0.03151981,0.006783833,0.03500784,0.058881193,0.084038846,-0.064398214,0.0077843107,-0.027604766,-0.033249028,0.053891018,-0.015369249,0.011376878,0.0038902864,0.039680116,0.0010945573,-0.024007266,0.032942917,-0.07238739,0.008150896,-0.04088718,-0.04849892,0.082125634,-0.001980664,0.081473224,-0.013570938,-0.065214016,0.013196555,-0.022648117,0.043066427,0.08322294,-0.0024142654,-0.046550795,-0.031881668,-0.02139885,-0.035761762,-0.0908202,-0.0013775378,-0.08574617,-0.03787524,-0.07379873,-0.033942685,0.017269997,-0.08510864,-0.0038654201,0.039319187,0.0025279634,0.15550976,0.021133063,0.011856125,0.0071705673,-0.040744934,-0.11473135,0.017153822,0.03377226,-3.3468467e-08,-0.040368915,-0.0129670985,0.054832835,-0.05010256,0.037139222,0.008609976,0.020450588,0.025624108,0.038642455,-0.04167094,-0.05602969,0.09708185,-0.040568274,-0.079006605,-0.012599948,0.026117995,-0.031316027,0.06872017,-0.036668576,-0.006960804,-0.06403144,-0.063448384,-0.08650225,0.10511375,-0.0011852055,-0.01689669,0.045622796,0.055802196,-0.073783435,-0.061049193,0.031099549,0.0150543675,0.07040358,-0.056878697,-0.09079467,0.007719589,0.05601091,0.0031992018,-0.046346482,0.068431556,0.009025647,-0.056435578,-0.03520088,0.0046883333,0.021209527,0.015968202,0.06284584,0.03937936,0.011117962,-0.011041145,-0.0048101344,-0.08110606,-0.07634939,-0.06279514,-0.07402011,-0.02035645,0.023944214,-0.049152274,0.010360474,-0.023877388,0.055912457,-0.0108142765,0.22419845,-0.06207621 +2.6.1.24,"A pyridoxal-phosphate protein. Also acts on 3,5-dichloro-, 3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and triiodothyronine.",384,0.99999994,-0.059532423,-0.09895681,-0.03878746,-0.10612271,0.1038244,0.012833342,0.05955008,0.0069332677,0.091942504,0.08460982,0.04741206,-0.0036430475,-0.08998443,0.10913805,0.007177057,0.060244046,-0.09349724,0.041042753,0.0047093863,-0.08072448,0.07102987,0.047603175,-0.008602909,-0.02054333,-0.037623286,0.09379047,0.069347434,0.080078065,-0.02540071,-0.06287838,-0.06568299,0.005257932,-0.022719257,-0.06572606,0.017879788,0.119496614,-0.11254174,-0.035537474,0.030968022,0.021372784,0.081611864,-0.0597502,-0.021128442,0.0210861,-0.0225553,0.0071430593,-0.019878954,0.046815526,0.0964915,0.004463849,-0.045984253,0.013328029,-0.026487317,0.033464003,-0.054497264,0.024991794,0.0102090575,0.052134663,-0.024697915,-0.010453526,-0.029495198,-0.03194295,0.050095264,0.03223082,0.07221723,0.027576838,0.011131751,-0.04592725,-0.056515526,-0.04686308,0.015466816,-0.022871124,0.09962118,-0.017438436,-0.012459997,0.049644705,-0.03106099,-0.014281334,-0.024266498,-0.016594335,-0.007212873,0.020144055,0.09404557,0.09089315,0.058005936,0.004608506,-0.06265446,-0.023743978,-0.008226436,0.0030162747,0.018526973,-0.0063484726,0.012739506,0.030510949,-0.023319958,0.04087456,-0.015665913,-0.025283316,-0.030654294,-0.03602449,-0.027389927,-0.008969411,-0.0840368,0.008549992,-0.027364621,0.028473167,-0.042292718,-0.0015068221,-0.04718099,0.0074883644,-0.06863711,0.02784573,0.028486967,0.00927506,-0.0072603845,0.0095638335,0.08522039,0.00077324355,-0.012460526,0.043889392,0.029782621,-0.056127045,-0.042608723,0.0822014,-0.068752,0.020528082,-0.057229966,1.281789e-33,0.07238752,0.04603179,0.017725471,0.07278487,0.0014432354,0.018293014,-0.04171363,-0.0747395,-0.06922007,-0.045348257,-0.0036780583,-0.023472305,0.06478781,-0.0074824067,-0.047739506,-0.03285376,-0.06566821,0.048679266,0.05585638,-0.05208527,0.057112794,0.1355069,-0.03031736,0.049992528,-0.0033487661,0.11331387,-0.052259732,0.010263692,-0.010861777,-0.015539339,-0.0051559834,-0.08733782,-0.04877219,-0.015895708,0.036785282,-0.035577632,-0.06050343,-0.054398023,-0.02630312,0.027341228,-0.05551558,-0.04159285,-0.09777787,0.010766935,-0.0040318617,-0.11540189,-0.020414779,0.017170781,-0.013688366,-0.003997882,0.046478644,-0.08240052,0.052551657,-0.05402131,-0.1022614,-0.047515586,-0.063501626,-0.066542014,0.035200275,0.052865624,0.06449506,-0.038469873,-0.02055052,0.012707166,0.036744952,-0.047274813,-0.028122088,-0.096808635,0.061051376,0.06521574,0.010601385,-0.00827407,0.05775459,0.0491142,0.024406161,0.011817862,-0.04655316,0.023315182,-0.04599882,0.049593087,0.04817304,-0.10363068,0.032325007,0.013024534,-0.043133005,0.006345325,0.023568116,-0.11801216,0.010833958,-0.054441422,0.082818955,-0.07452841,-0.044830266,-0.043642126,-0.020520031,-1.6065255e-33,0.046797182,-0.041845307,0.065749325,-0.011729614,-0.07287834,0.041432906,0.0007278762,-0.017374242,0.069529526,0.062432658,0.043111354,-0.02145417,-0.051000167,-0.09347416,-0.027130013,0.06985643,0.032683033,0.005377307,0.020612339,0.014244057,0.0126508875,-0.017922556,0.025851622,0.10217772,0.03772386,0.09811177,-0.02318198,-0.02670532,-0.01953752,0.043779556,-0.053013947,0.021136748,0.038007673,-0.042025007,0.00787252,0.0007643266,-0.07635799,-0.0069213132,-0.031751044,-0.018628588,0.015134762,-0.016189342,0.10101595,-0.010241423,-0.058112632,0.028781945,-0.033503734,0.017285276,-0.024442835,-0.02827577,0.0011535917,0.0416141,-0.00047755806,0.017606433,0.030894179,0.010962398,-0.02649463,-0.0077625625,0.018054185,0.04672537,0.014331626,-0.051033232,-0.013335399,0.070135884,0.082122356,0.07760633,-0.022791807,0.0042888476,0.08594485,0.07050888,0.052066404,0.04954715,0.09797361,0.038320556,-0.0649734,-0.030565647,-0.039675962,0.03526193,0.038326036,0.03153938,0.0012177099,-0.010468397,-0.023022076,-0.058320977,-0.00028553625,-0.044690453,0.057317283,0.09261921,-0.021352777,0.0025377765,0.016755655,0.024765674,-0.039026797,0.0556687,0.06673481,-4.1231466e-08,0.08976166,-0.07262115,0.004987064,-0.05585719,-0.037897583,-0.012911958,0.10304444,0.026051844,0.086227,0.016741311,0.058240134,0.01536163,0.058325574,-0.052776724,0.08897417,0.062314652,0.009016899,0.007949277,0.00637135,-0.060740016,-0.02685084,0.00950446,-0.070014946,-0.020512626,0.067993425,-0.011840053,0.0052169496,0.027050164,0.038946442,0.02178205,0.027103392,-0.050515767,-0.0304133,-0.1023503,-0.03606891,0.08305186,-0.08264715,-0.054816518,-0.052150507,0.016651843,-0.075962864,0.052537065,-0.026381634,0.009051397,-0.0025641064,0.031025827,-0.05521416,-0.007620061,0.014848786,-0.059524614,0.044270463,0.008093442,-0.03419639,-0.05077245,-0.19577792,0.025010888,0.043668237,-0.031991567,0.0074482206,-0.09787353,-0.055398498,-0.009212367,0.123906694,-0.0349077 +2.6.1.26,"A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors.",384,1.0,-0.07183457,-0.093095936,-0.028743574,-0.056302045,0.06362433,0.011951907,0.00236647,0.019162392,0.061268903,0.024596516,0.029208204,0.0015437728,-0.104539074,0.12087425,0.032404695,0.063333645,-0.0751972,0.018314505,0.08336365,-0.061140962,0.054010853,0.0061300434,0.020823983,-0.018218646,0.018569078,0.0621581,0.042081136,0.078686476,0.01682031,-0.07914607,-0.07798627,-0.004819249,-0.02847095,-0.031745948,0.026986122,0.17585257,-0.10666743,-0.005938581,0.017473117,-0.04391867,0.10670591,-0.08350699,-0.012646453,-0.013980969,-0.035921626,0.0053668404,0.010163179,0.068739206,0.03590255,-0.0035296248,-0.05635135,0.023769794,-0.016700726,0.034595825,-0.047051772,0.07289108,-0.00013725134,0.053960484,-0.021855144,-0.08280591,-0.010150313,-0.031920675,0.046940845,0.0027155608,0.027670655,-0.02887085,0.024892798,-0.026155142,-0.018952304,-0.023955906,-0.048260227,-0.037886757,0.09081038,0.03284971,-0.008921136,0.026986279,-0.08543749,-0.029113194,-0.026808228,0.017982256,-0.031523403,0.018521369,0.0406377,0.029722964,0.046269163,0.005622439,-0.065882765,-0.007538992,-0.06449676,0.0063577667,0.014460726,-0.0030133233,0.09213814,-0.019489674,0.014486175,-0.008022117,0.03020037,-0.004426294,0.01630943,-0.030385083,-0.0045661754,0.044631705,-0.13315389,-0.03535502,-0.04215989,0.03336842,-0.025642458,-0.024020653,0.00803434,0.023029124,-0.04771564,0.02403644,0.07376232,-0.0013421214,-0.008824045,0.031006956,0.00027979654,-0.015789963,-0.016733272,0.07396462,0.0068293177,-0.07985929,0.00825065,0.10466353,-0.06941779,0.035205267,-0.08969594,9.476072e-33,0.05139095,0.004606255,0.0022707044,0.025950562,-0.027797606,0.01778306,-0.033112466,-0.009621245,-0.047170274,-0.0444742,-0.07418507,-0.012184113,0.10197568,0.07728865,-0.070213616,-0.046765525,-0.05204017,0.059860397,0.07940346,-0.060999885,0.07533471,0.12095562,-0.009822067,0.09096909,-0.015477512,0.04959536,-0.09387596,0.030899059,-0.0057092044,-0.021045646,-0.01812039,-0.10158211,-0.060599085,0.018345388,0.041450813,-0.06205165,-0.05763224,-0.06349603,-0.035701122,-0.03267798,-0.09373336,-0.037544005,-0.10065665,0.010953977,-0.007036481,-0.082242765,0.025164742,0.018286271,-0.028497055,0.019590037,0.06370195,-0.07874981,0.046171065,-0.13301344,-0.051169273,-0.033971023,-0.006979964,-0.018214336,0.033438105,0.050474856,0.059576854,-0.0020162843,-0.011160265,-0.06741859,-0.06671837,0.0016750088,-0.05102824,-0.08679915,0.0035548545,0.08131069,0.012722821,0.040956598,0.0016687857,0.053738292,0.03635544,-0.042993937,-0.059720073,0.028447188,-0.014114582,0.008327474,0.00037170024,-0.09476009,0.0064341654,-0.020405445,-0.040955767,-0.0066324943,0.013362368,-0.11974038,0.046616293,0.004742426,0.04084966,-0.05161662,-0.061334793,0.006870952,0.053193405,-9.050139e-33,0.07359174,-0.03464025,0.02183816,-0.02644629,-0.053650312,0.023594849,0.045582943,-0.035338446,0.082670785,-0.0015180229,0.07935795,-0.027586622,-0.020207714,-0.04928831,-0.012696201,0.045362245,0.0052329465,0.017528009,0.010271798,0.043608103,-0.0711731,0.02772978,-0.021501679,0.08030689,0.03474368,0.083602466,-0.049472004,0.027255883,0.025025992,0.029479804,-0.06569625,0.04922255,-0.020298496,-0.020091394,-0.0021463197,-0.0014999837,-0.10255094,-0.015566328,-0.03564204,-0.03842108,0.05808337,0.038045947,0.07434994,0.072244376,0.027274812,-0.021774264,-0.004444281,0.012170063,-0.050134297,-0.02633263,0.010706321,0.064757735,0.03530476,0.038688794,0.0763818,0.07454545,-0.006920956,-0.0076382244,0.038378704,0.0048272237,-0.027960865,-0.121523835,0.002002828,0.06717455,0.08331492,-0.0007198259,-0.039903715,0.030305086,0.038570676,0.101427115,0.08376347,0.0055819703,0.051456537,-0.008998402,-0.019332634,-0.00794348,-0.03919886,0.030199535,0.021856742,-0.040823355,-0.05749135,0.002184005,0.0015931639,-0.1033709,0.012515114,0.0070111537,0.022040624,0.03321846,-0.039992064,0.036199596,0.018751174,-0.02726533,-0.0012077967,0.049082402,0.0958877,-5.127678e-08,0.08544677,-0.042236555,0.037519902,-0.023317115,0.013743899,-0.0520953,0.056259464,-0.04346277,0.054277953,0.018223725,0.012144704,0.010482544,0.087007105,-0.06537011,0.08812417,0.07567947,-0.020499436,0.080607004,-0.016563317,-0.029054552,-0.052694984,-0.009637884,-0.111012295,0.05341201,0.02744209,-0.009584126,0.02695788,0.01327084,0.04674637,-0.03555009,-0.00055180455,0.0034793024,0.013074197,-0.09282328,-0.0045486162,0.06913285,-0.004057352,-0.025544586,-0.061630074,-0.0034623581,-0.043172926,-0.027393404,-0.06186868,-0.021970043,0.0104984995,0.09657094,-0.018322425,-0.031798467,-0.016890237,-0.035715114,0.07449807,-0.033493157,-0.030667627,-0.031693157,-0.12100288,0.05417355,0.0049138484,-0.016543675,-0.00229421,-0.10015663,-0.014285867,0.035772253,0.15329736,-0.08998256 +2.6.1.27,"A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.",384,1.0,-0.034763705,-0.113282844,-0.027219094,-0.067038275,0.052851256,0.07771208,0.07015508,-0.028584246,0.07451172,0.056353435,0.04372369,0.046942193,-0.09993777,0.10805123,0.001877113,0.06690745,-0.05066287,0.018126054,-0.023777258,-0.073023796,0.10744164,0.027697051,-0.018542685,-0.00075000594,-0.006349281,0.04499271,0.065660335,0.030395975,-0.0051708505,-0.037892427,-0.013859355,-0.0020269945,-0.05237915,-0.043713342,0.032849353,0.1265652,-0.06694219,-0.0426075,0.04616343,0.0025351832,0.08484533,-0.07827832,-0.036121882,0.00029049016,-0.077539064,0.0015078081,0.053929593,0.07263122,0.045808375,-0.051397394,-0.08317464,-0.04242758,-0.05394987,-0.0051384387,-0.019522408,0.055539567,-0.015083139,0.010120999,-0.031539883,-0.02018337,-0.04320176,0.046619646,0.019489909,0.029467486,0.034707006,-0.023073718,-0.004713154,-0.05727294,-0.0022839224,-0.014277521,-0.00907606,-0.040080674,0.114683874,-0.007683723,-0.0142345205,0.0018994986,-0.078331135,-0.052054748,-0.032460388,-0.022106387,-0.018655846,0.039721653,0.019200541,0.10148877,0.07691555,-0.020069456,-0.040384445,0.022755174,-0.03740504,-0.0655093,0.040743798,-0.024201779,0.028575255,0.061944865,-0.03135956,0.01857683,0.015999952,-0.09032932,-0.041436244,-0.020556273,-0.006416505,0.029147113,-0.020086918,-0.03624302,-0.054557417,0.016122064,-0.026658062,0.0147320265,-0.031603247,-0.033075146,-0.076371215,0.020797502,0.010710643,0.018655326,0.011130062,0.029944003,0.011994511,-0.0058657895,-0.042595617,-0.041929375,-0.029556287,-0.0055804276,0.013793365,0.103376105,-0.08923523,0.024170768,-0.11558709,-1.3321879e-33,0.10048572,0.0016836108,0.058052704,0.02536839,-0.004161535,0.022715375,-0.050792277,-0.034087837,0.03424204,-0.022682386,-0.018295258,-0.056078393,0.07405497,0.021452311,-0.05755655,0.008259545,-0.15241513,0.08066061,0.11228085,-0.012196866,0.008872365,0.08058022,-0.060028516,0.052321933,-0.013542614,0.09111208,-0.033387978,-0.0028823528,0.00077566906,0.011859536,-0.0066463207,-0.056958746,-0.1536119,-0.025748601,0.032975636,-0.051412657,-0.04252551,-0.05932774,-0.04013087,0.026033487,-0.036195874,-0.05554041,-0.042990334,0.016897142,0.044514365,-0.04608613,-0.014000441,0.061745726,-0.0029935143,-0.006144206,0.049956404,-0.09385794,0.07645488,0.00062286516,-0.14266768,-0.032644637,-0.029249392,-0.041234188,-0.0002694493,0.03656507,0.027101954,-0.023585696,-0.027180295,-0.015072684,0.007986217,0.016028805,0.00021677332,-0.09116161,0.048594628,0.080535635,-0.011268651,0.02039839,0.08863804,0.072568685,0.036662452,-0.054376647,-0.035565995,0.00012942146,-0.016480448,0.11481197,0.023642987,-0.09786135,0.0036165009,-0.038701806,-0.04788362,0.024051014,0.06676725,-0.12575921,0.015653912,-0.033198167,0.057336777,-0.122886725,-0.03265929,-0.00096608076,-0.018974185,-7.884833e-34,0.06106217,-0.09365067,0.027142748,0.015123272,-0.04334542,-0.037935134,0.08387479,0.0035438684,-0.004976554,-0.020561606,0.054272827,-0.0041113133,0.010733423,-0.04219802,0.02333489,0.057874594,-0.058756277,0.03129206,0.06472297,0.05059265,0.014011314,-0.0144914,0.03203494,0.070923895,0.10957798,0.07913254,-0.0016372759,-0.005663663,0.0057508694,0.046218887,-0.002397082,0.040462364,-0.044730533,-0.08338408,-0.026148278,0.030884383,-0.11986794,0.011265092,-0.031026863,-0.0069474424,0.045237552,0.0319358,0.089405544,0.013681629,0.009949151,0.06390321,-0.015986823,0.022764849,-0.037770122,-0.047289584,0.009856071,0.071482934,0.0017585409,-0.024623448,0.05448571,0.047087368,-0.038892455,0.049282443,0.030947508,0.01183288,-0.03394603,-0.05925866,0.038120683,0.06382073,0.02779116,0.06422155,0.027602311,0.020559806,0.079533696,0.06318446,0.040226206,0.0009129559,0.11186871,0.07802182,-0.06577168,-0.015731014,-0.044406015,0.039085995,-0.0088974405,0.042160794,0.013747617,0.0020835015,-0.01768809,-0.09316282,0.02337292,-0.046239164,0.055541553,0.08712678,0.013995676,0.034841746,0.021655127,0.018827427,-0.030612813,0.010767414,0.06762481,-3.0126458e-08,0.07137128,-0.045156047,0.040316317,-0.06798637,-0.011835346,-0.025600234,0.048416007,0.0067148856,0.078888826,-0.039104864,0.03408155,0.0067658196,0.027657643,0.046652608,0.016289541,0.024654629,-0.036230665,-0.013413106,2.5340334e-05,-0.06238385,-0.07837106,0.0021840916,-0.09171044,0.03561154,0.048158783,-0.01705182,-0.0048609246,0.04208487,0.0117347315,-0.024255546,0.049035247,-0.013795675,-0.008369184,-0.05984356,0.0058852476,0.12951529,-0.066270664,-0.019810438,-0.045703217,-0.011194826,-0.076907866,-0.03259282,-0.006553513,-0.009406803,0.050348487,0.022941727,-0.06386668,0.004253947,-0.009158197,-0.011206794,0.034805436,-0.004075319,-0.05034098,-0.06318933,-0.15223348,0.022215325,-0.02433315,-0.06286896,-0.022885777,-0.09706824,-0.03774301,0.01729315,0.08184488,-0.03984167 +2.6.1.28,"Valine, leucine and isoleucine can replace tryptophan as amino donor.",384,1.0,-0.003294935,-0.026308497,-0.07122482,-0.053130407,0.029079063,0.06446109,0.02635176,0.043710597,0.026942378,-0.022351392,0.006466252,-0.026696648,-0.069356576,0.10087143,-0.011684585,0.007861684,0.03533653,0.04609023,-0.040696617,-0.018607896,-0.02635735,0.069069676,-0.06527188,-0.0028518303,-0.01895438,0.0018597821,-0.025125006,-0.012962581,-0.005949532,0.004128131,-0.052439235,-0.094933175,-0.044820145,-0.04066339,0.029555058,0.058570713,-0.05837162,0.042233188,-0.01043069,0.003010897,-0.011142725,-0.02235844,-0.025737429,-0.0011465787,-0.032951895,0.00078403536,0.03978157,0.000854349,0.044096477,-0.009761165,-0.012381603,-0.055300657,-0.049082737,0.048397593,0.04900139,0.121009775,-0.037530113,-0.0146764945,-0.003628504,4.5139193e-05,-0.05321778,0.10443593,0.02352412,-0.05410248,0.09248268,0.022611057,0.0016668814,-0.0713736,0.03710439,-0.033245288,0.04166416,-0.035526443,-0.033682596,0.050470166,0.026275175,0.004253213,-0.028611613,-0.01577673,-0.0037225785,-0.0059562605,-0.046262935,0.01261811,-0.01710829,0.09553564,0.03774775,0.027012099,-0.08754102,0.09132594,0.009793981,-0.027790066,0.08456866,0.0008111924,0.024484757,0.005999787,-0.012111857,0.01682355,-0.039947573,-0.05899068,0.022210766,-0.002736102,-0.0030188286,-0.025837889,-0.12843867,-0.1023511,-0.03582564,-0.0006307325,0.0667776,0.02217069,0.016527394,-0.044363532,-0.017380087,0.00097060535,0.0803211,0.035126176,-0.024232477,0.021825995,0.023233505,-0.031756837,-0.07459649,-0.04257594,0.020642186,0.04191574,0.106972046,0.091788806,-0.021948226,0.0075308927,-0.0665312,2.5323408e-33,0.048643492,0.024925334,0.08709028,0.059399072,-0.041795675,0.05465242,0.005516494,-0.018254254,0.0733867,-0.10979577,-0.15252851,-0.103750765,0.04203784,-0.0014903725,-0.018829446,0.017967945,-0.12590215,-0.0069797193,0.042714495,0.027243452,-0.054408003,0.043200355,0.042133298,0.015345873,0.040665384,0.00053608237,-0.01921048,-0.017888088,0.0499962,-0.0006361755,-0.066058375,0.016363718,-0.10444592,-0.0010410012,-0.027378868,0.02422512,0.043893516,-0.00472679,-0.04112104,0.063081674,0.026819052,0.06478296,-0.005771094,0.033162177,0.13827302,0.017802684,0.018726308,0.05600854,-0.032085102,-0.050287206,-0.008256243,-0.06862358,-0.01303747,-0.05523487,-0.13171147,-0.030392935,-0.0034218323,0.038562767,0.022828605,0.09371065,-0.040328257,0.08385286,0.047929443,0.030580048,-0.024622763,-0.0008018135,-0.05258839,-0.106155045,-0.03371463,0.019213613,-0.047115855,-0.021592457,0.020027513,0.036218334,-0.028921818,-0.10689532,-0.016676469,0.010582385,0.06276293,-0.036269497,0.07349197,-0.04816241,0.01937957,-0.020073768,0.016544329,-0.071202345,0.05369808,-0.12973183,0.01366028,-0.015380261,0.056377616,-0.0022491273,-0.05251599,-0.061391417,0.0323291,-3.2479824e-33,0.045848276,-0.13409813,0.023300152,0.0388153,0.008024866,-0.0021905866,0.002038612,-0.096886516,0.07619344,-0.013943215,0.11046182,-0.104464725,0.06790925,-0.056156065,-0.03040626,-0.079597056,-0.11433238,0.033189666,0.04068769,-0.041902937,-0.03431523,0.0100810835,-0.040889077,-0.043712113,0.05170617,0.06023739,-0.07907803,0.08342259,0.07302956,0.00942856,0.041557193,-0.007677495,-0.099792704,-0.053184185,0.044620216,0.11051444,0.01713257,0.02183846,0.0014017529,-0.0021005634,-5.647508e-05,0.01169032,0.09846116,-0.0019183783,-0.05459654,0.0845686,-0.034049276,-0.006172324,0.006775087,-0.090828724,0.088966146,-0.08762784,-0.056554258,0.018331435,0.048173435,0.025641238,0.01993145,0.002010886,0.03844281,-0.04464692,-0.042441722,-0.016966568,0.065534756,-0.01606991,0.018988337,-0.0064258366,0.058582343,0.06102894,-0.0067431363,0.015766779,0.06255796,-0.071879394,0.10193421,0.06989004,-0.026938159,-0.062518924,-0.011256595,0.011887261,0.05557437,-0.036818378,0.0143404845,-0.0018257088,0.010535325,0.019883165,0.05346384,-0.00790886,0.059833556,0.112105794,-0.00300528,0.005636359,-0.052142292,0.0029111821,0.040809713,0.04121888,0.11125177,-2.3471005e-08,0.08930179,-0.024108686,-0.048119627,-0.014193179,-0.042815432,-0.037680123,-0.026974782,0.031852078,0.019029193,-0.023683341,-0.03947961,0.05478915,0.012314149,0.02808376,-0.05087798,0.03094433,-0.017604154,0.0065865773,0.0024603922,0.00058129017,-0.083344586,0.0119016245,-0.049828164,-0.094165295,0.005941759,-0.038711764,0.020786311,0.05067965,0.069060236,-0.09873689,0.010675947,-0.05844782,0.021715995,-0.05599107,0.043768898,0.07756845,-0.053823978,0.024229357,0.033700425,-0.021443764,6.220495e-05,-0.051753256,-0.09061178,-0.014144829,0.020693427,-0.121724755,0.026480872,0.024047334,-0.044359695,0.014962358,0.033004273,-0.006178019,0.03582591,-0.033212986,-0.012988011,0.02501413,-0.03788504,-0.039090853,0.05129684,-0.05616751,0.037364762,0.019838873,0.07822875,0.05244067 +2.6.1.33,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.34,"A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [2-4] and O-linked glycosylation of certain L-serine residues in Neisseria species 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+2.6.1.35,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.36,"A pyridoxal-phosphate protein. The product (L-allysine) is converted into the intramolecularly dehydrated form, (S)-2,3,4,5-tetrahydropyridine-2-carboxylate.",384,0.99999994,-0.012072589,-0.10274333,-0.04334448,-0.045822084,0.06056576,0.06054823,0.037587278,0.060083974,0.03414431,-0.009963365,0.059824042,0.026635658,-0.08894068,0.07846165,-0.02173762,-0.008848761,-0.056639053,0.01480024,-0.033145104,-0.055074625,0.07596217,-0.018904295,0.0004588082,-0.009417135,0.0898122,0.051588017,0.085838,-0.003276095,0.019924883,-0.08485449,-0.03225947,-0.0010445074,-0.0613732,-0.1038258,0.0948687,0.11446504,-0.04250713,0.004831874,0.013691093,-0.03401268,0.040678073,-0.079813205,-0.010036889,-0.00050849904,-0.07756206,0.0006637328,0.01986083,0.11441113,-0.01638123,-0.010321511,-0.042061415,0.030118532,-0.06576653,0.0007865236,-0.04872199,0.05055861,-0.010410323,0.035727244,-0.06872496,-0.008789569,0.035343856,0.035128884,0.009377192,0.01255912,0.007886489,-0.06918163,0.041567765,0.010525124,-0.006711117,-0.019779913,-0.066715606,-0.00010016073,0.078444265,0.012386736,-0.017222246,0.05990936,-0.009812473,-0.053047493,0.027732892,0.049907073,0.026254028,0.02270707,0.017329073,0.08295098,0.052633718,-0.00035036524,-0.043603037,0.018910646,0.032196745,-0.060798105,-0.020414732,0.014233555,-0.027452746,0.026022514,-0.053657167,0.03968729,-0.018510947,-0.056500077,-0.025825756,-0.003277613,-0.007969635,0.019670935,7.8220524e-05,-0.077457406,-0.034803152,-0.019582564,-0.038980562,0.034683943,0.043206923,0.011555763,-0.045440998,0.019737137,0.0068054707,0.014557642,-0.032815505,0.028418854,0.0007714357,-0.05715476,-0.011761128,-0.03832217,0.012993548,0.019291831,-0.013063345,0.07818088,-0.018143075,-0.029087856,-0.12953514,3.0484283e-34,0.034235228,0.07553278,0.06048527,0.11904011,-0.03750714,0.007209174,-0.08667413,-0.043795113,-0.11901216,-0.01814635,-0.081897415,-0.06058847,0.09779915,0.03826208,-0.038232923,-0.045070905,-0.08937832,0.07593229,0.052949514,-0.025795175,0.02461108,0.1526937,-0.0339597,0.111366384,0.038106468,0.036590233,-0.0119418325,0.008590488,0.03456801,-0.0018802949,-0.0035854613,-0.07752507,-0.09530906,-0.050978325,0.07818021,-0.09182942,-0.048199266,-0.10129279,0.014476375,0.06861384,0.08219931,-0.044742987,-0.021171018,-0.025443003,-0.0033580654,-0.1010214,0.021030312,0.0633526,-0.023972103,-0.07441627,0.08275948,-0.03396834,0.0358896,0.017276015,-0.122814134,-0.0033720694,-0.06415717,-0.011990896,0.048865095,0.018238321,0.05000095,0.003176414,-0.028009042,-0.05410001,-0.014389326,-0.08409718,-0.025238192,-0.07318434,0.037289135,0.020393493,-0.04596524,0.017614191,0.07274173,0.054163042,0.034942344,-0.036644958,-0.022022555,0.046400383,0.06855407,0.019860977,-0.042509895,-0.05784919,-0.044699956,-0.033349935,-0.05651829,-0.058275152,-0.030416315,-0.098116055,0.022685783,0.036232073,-0.0127105545,-0.11382601,-0.05227262,0.018994097,0.024514789,-2.0584532e-33,0.007861019,-0.0455775,0.068581834,0.014375128,0.022925872,0.0048619634,0.06915767,-0.027667431,0.10085628,0.022121178,0.024348864,-0.017269138,0.02853767,-0.048874877,0.0238428,0.058234837,-0.00048161543,-0.0036779288,0.076522686,0.0065766475,0.034535747,-2.194876e-05,0.11136199,0.072418064,0.052502293,0.06369125,0.044884045,-0.0059349416,0.018203193,0.050785467,0.043365486,-0.017931016,-0.043508124,-0.07159093,-0.106501594,0.043171555,-0.07812611,-0.061677642,-0.022319566,-0.020705432,-0.0070779053,0.00996449,0.043945417,0.037936583,0.012417272,-0.008617709,0.008509795,-0.05783475,0.0014897968,-0.02993544,0.04391566,0.038352787,-0.029957665,0.00542685,0.026271785,0.0072181798,0.026554065,0.011422249,0.010278632,0.025193693,-0.014624757,-0.11450586,0.016055575,0.0054936265,0.036764693,0.05707312,0.014719267,0.06495417,0.084563404,0.007679477,0.0908875,0.048926193,0.024304798,0.081853755,0.025347061,-0.039365213,-0.045225356,-0.027149554,0.05640068,-0.077847,-0.065733775,-0.050644804,-0.013500204,-0.05530784,0.030903718,-0.08545123,0.07143331,0.116750486,0.025806129,0.015491277,-0.019801496,-0.023130776,0.0032743504,0.064739235,0.060116544,-4.090689e-08,0.05407789,-0.06892296,-0.0057979804,-0.03392246,-0.054911926,0.009097555,0.07771499,0.0242617,0.050895635,-0.04472888,0.035551757,0.0061028614,0.009293016,-0.0016643276,0.0699452,0.055215433,-0.037788454,0.041327536,-0.0272845,-0.056994736,-0.016072327,0.018631175,-0.07726569,0.0071902354,0.022185154,0.0036896812,-0.018715266,0.026958117,0.013737431,-0.022604363,0.047676496,0.025540002,-0.013676536,-0.02861362,-0.06117853,0.06123093,-0.07042428,0.03626528,-0.057916988,0.055044044,-0.038309533,0.047543116,-0.024114452,0.010719071,-0.03353535,0.040156327,-0.06193088,0.03967195,-0.017344436,-0.01761322,0.061582636,0.007184589,-0.12180488,-0.072667055,-0.11759153,-0.0117043955,-0.031724256,-0.038362138,0.059178423,-0.109396935,-0.100736484,0.03888028,0.08895031,-0.033662163 +2.6.1.37,A pyridoxal-phosphate protein. 2-Aminoethylarsonate can replace 2-aminoethylphosphonate as a substrate.,384,1.0,-0.014714201,-0.09272742,0.023866866,-0.13788244,-0.009551993,0.048401553,-0.001962108,0.019486593,0.018371334,0.061412625,0.021998083,0.011050708,-0.0077209845,0.10082085,0.016040308,0.03640412,-0.0845129,0.04103943,0.012467003,-0.014020762,0.09324743,0.04976375,-0.0056428737,-0.047915205,0.061075028,0.092308246,0.018098516,0.04145319,0.015298652,0.010597022,-0.0019795075,-0.008162125,-0.032436464,-0.1344572,0.041587196,0.0893868,-0.072675146,0.02080129,0.004522849,-0.055106193,0.07788473,0.013809736,-0.044829555,-0.01115739,-0.0993925,-0.0054386025,0.03552663,0.024152262,0.05962441,0.021638017,-0.054943454,-0.055397652,0.020552266,-0.039188962,-0.01831752,0.14262937,0.04479028,0.08950394,-0.054093346,-0.009574504,0.0086956415,-0.01414794,-0.0010357196,0.037686583,0.060105555,0.024245992,0.05776143,-0.0475347,-0.0007585071,-0.014097733,-0.03601588,-0.040884167,0.094830185,-0.024210745,0.004516804,0.06515218,-0.0069957906,-0.04180411,-0.0132002635,-0.0057268403,-0.0135513805,-0.04192749,0.038167898,0.0041855425,0.032208875,0.032150857,-0.011477676,-0.02405519,-0.011575715,-0.030977463,-0.043989368,0.019557191,0.07453979,-0.03835144,-0.007291357,0.08464739,-0.03039969,0.029265478,0.029941486,0.0023280089,0.0128288595,0.035473593,-0.0006127674,-0.087824,-0.026868837,-0.02740811,-0.13824056,-0.009832537,-0.05213588,-0.037899993,-0.011848311,0.060875464,0.036677938,0.031413306,0.008070773,0.046884757,0.04029575,0.0259943,-0.06985132,0.04723092,-0.002742763,-0.06569639,-0.027233597,0.041638393,-0.065122604,-0.027640002,-0.07073522,9.487921e-34,0.033964522,0.05032394,0.084842704,-0.0066760005,0.027037174,-0.027868636,-0.06337173,0.007647132,-0.020277528,-0.095426455,0.030730965,-0.04793539,0.05525762,-0.010058249,0.013940417,-0.024394544,-0.03486294,0.10487169,0.08484243,-0.04478204,0.04823173,0.08543481,0.028257865,0.059421327,0.04069957,0.004471764,0.016985191,-0.032643802,-0.0069383224,-0.01503362,-0.061815377,-0.08020544,-0.10107843,-0.041515574,0.02327639,-0.106934085,-0.052465357,-0.1016121,-0.0020754247,-0.058153495,-0.0082107335,-0.035756543,-0.01455477,0.042954966,0.021018784,-0.067337826,-0.054662153,0.028364075,-0.028104406,-0.015010906,0.046798322,-0.029798178,0.04270512,0.0058783,-0.0730137,-0.039468043,0.0024357983,-0.0730016,0.03688135,0.018674053,0.029657496,-0.010190859,0.012213953,-0.0055480166,0.027999504,-0.06766557,0.0018775205,-0.09538406,0.024112146,0.075884074,0.066245906,-0.029650578,0.026796447,0.10167328,-0.015786074,-0.07180158,-0.016729759,0.027028717,0.03328331,0.07742304,0.0105071,-0.015815604,-0.067980155,-0.011509437,-0.0069564506,-0.117704846,0.046185873,-0.0784501,0.014103152,0.03137032,0.004788937,-0.07232956,-0.09072066,0.027429692,-0.01843911,-3.0682708e-33,0.06311306,-0.03619314,0.073159926,-0.021690212,-0.07174386,0.028124174,0.08013605,0.031006804,0.029831756,-0.011019466,0.046512563,0.013318646,0.035522774,-0.023624627,-0.070188805,0.022376072,0.03922345,0.048321698,0.0327161,0.039540436,0.07765499,0.019920312,0.031123096,0.12457543,0.050148215,-0.024731643,-0.031610038,0.026468549,-0.07444734,0.09998238,0.0002726078,0.04043441,-0.020505827,-0.056288,-0.032585308,0.05999048,-0.01446653,-0.04393905,-0.012750955,-0.010357197,0.02349678,0.0759154,0.06458715,-0.026088092,-0.050448902,-0.026176326,-0.0036199226,-0.0039218236,-0.05357231,-0.096210904,0.018139409,0.047434803,-0.028520366,0.00024701987,0.017353924,-0.005516903,-0.015578615,-0.037107572,0.012302656,-0.009159315,-0.0090276,-0.08785342,-0.020432549,0.03807227,0.031328537,0.051821638,0.032513328,-0.0021129062,-0.0059935153,0.025875622,0.06264307,0.0377278,0.09127495,0.12334297,-0.0504278,-0.021996556,-0.04663476,0.007822545,0.008231299,-0.087461054,0.04343601,0.01162499,-0.022042394,-0.04631684,0.047138814,-0.06860732,0.11027948,0.066243775,-0.044340584,-0.016321888,-0.008943511,0.038075455,-0.02167655,0.06538813,0.13481224,-2.808089e-08,0.07883033,-0.007841736,0.06791172,-0.08663463,-0.033664003,-0.035467796,-0.015239562,-0.026459293,0.05962627,-0.08164313,-0.01862492,-0.033108953,0.041364904,0.028585821,0.0124995755,0.083580256,-0.03832321,0.037386935,-0.042655732,-0.0953129,-0.070441134,0.047324367,-0.07957483,-0.0061321603,0.026250355,0.047806203,-0.0033745954,0.029524969,0.007619947,-0.022954293,0.033216618,-0.034198914,-0.036833428,-0.05679384,-0.025772572,0.035947718,-0.02555678,-0.0458272,-0.07607238,-0.0055850483,-0.0793322,0.020969389,-0.004325652,0.049746178,0.02818004,0.007850204,-0.03370237,0.05314076,-0.039433602,-0.029594667,0.10115943,0.011839073,-0.039702345,-0.16868079,-0.13810384,0.022842053,-0.008095033,0.016657224,-0.030810952,-0.05481431,-0.026511712,-0.03033255,0.12432195,-0.071358524 +2.6.1.39,A pyridoxal-phosphate protein.,384,0.99999994,-0.027926307,-0.082669966,-0.06864404,-0.0736116,0.027612139,0.00069278304,0.043136388,-0.0022198383,0.07759752,0.061581366,0.050052542,0.024383662,-0.07972978,0.075630225,-0.018062996,0.011146767,-0.058814332,0.026981099,0.028646505,-0.060484987,0.08062581,0.046058796,0.013964545,-0.0034948976,-0.022635197,0.09317548,0.03897881,0.08481283,-0.022757838,-0.06512055,-0.033645604,-0.002438178,-0.04265655,-0.081326276,0.049699727,0.09206192,-0.10426549,0.024624566,0.01641356,-0.038264256,0.09138554,-0.06995117,-0.019178458,0.015225969,-0.079754055,-0.009005391,0.060174454,0.06121611,0.1076781,-0.0044863066,-0.08720911,-0.014019634,-0.013987518,-0.049955927,0.010103739,0.04439458,0.025756652,0.03877331,-0.030249724,-0.031439897,-0.018875996,-0.014899653,0.033183742,0.03005634,0.045147188,-0.03863779,0.011696549,-0.046883464,-0.028674698,-0.0040879943,-0.0399809,-0.0017529497,0.12130531,0.0010538863,-0.034636367,0.09728037,-0.028074443,-0.023704544,-0.04040873,0.055432733,0.03498061,0.00886843,0.038521856,0.08173242,0.056242175,0.02956211,0.015032759,-0.008670652,-0.0671204,-0.03498028,0.0024070852,0.025017837,0.033844747,0.03431295,-0.017365431,0.020294111,0.0095834825,-0.017277373,-0.049156386,-0.05037137,-0.0135520855,0.006560372,0.029906176,-0.04925029,-0.040218767,-0.005961301,-0.070319004,0.04136831,-0.008511003,-0.0040058997,-0.05803713,0.0810462,-0.012979407,0.006107804,0.023426063,0.022639925,0.016739301,-0.004660274,-0.05652102,0.057704583,0.0031750596,-0.032194667,-0.030190036,0.08859248,-0.054773755,-0.0542106,-0.07686096,-2.4678308e-33,0.06313784,0.074121,0.050783433,0.040298108,-0.011358971,-0.014224093,-0.06284932,-0.054584622,-0.06972202,-0.006010194,-0.005837788,-0.041249312,0.07401363,0.007710753,-0.07779482,-0.03148981,-0.09894455,0.03780528,0.09449977,-0.054316152,0.036347546,0.122786574,0.015729465,0.06573166,-0.023447253,0.10535222,-0.04718892,-0.017551308,-0.020911029,-0.010473525,0.017130276,-0.08890346,-0.10486213,-0.037216794,0.029635139,-0.1032107,-0.053137314,-0.088244945,-0.028490026,0.010690034,-0.031340834,-0.06654564,-0.015844474,0.03225437,0.005228752,-0.12502499,-0.022130616,0.049036965,-0.04441586,0.030425001,0.03924025,-0.065284304,0.07721513,-0.0022649365,-0.14055419,-0.054724984,-0.056979842,-0.04121839,-0.0039615375,0.036306877,0.055933136,-0.0074688112,-0.0776967,0.005927369,-0.007340223,-0.05244896,0.01644481,-0.06923204,0.06292541,0.08146769,0.070626065,-0.021183291,0.08123207,0.022367109,-0.017924992,-0.0069551063,-0.03999482,0.04453336,-0.028805178,0.099463925,-0.02261902,-0.0688775,-0.055661384,-0.03151839,-0.050702408,0.0006394455,0.025497343,-0.05753736,0.047344767,0.00027531275,0.030769043,-0.11320937,-0.0680435,0.018650109,-0.030141242,3.6575068e-34,0.07618561,-0.056287874,0.10101466,0.007109189,-0.055663213,-0.0030681002,0.0774277,0.02046836,0.023406582,0.0041982206,0.0350583,-0.0105334455,0.015140504,-0.066251345,-0.004752528,0.054859713,-0.009271968,-0.005652817,0.058509693,0.04026011,-0.003693155,0.011792269,0.016480174,0.09651126,0.053761203,0.075716525,0.01452238,-0.0019530556,-0.07552723,0.029911192,0.030482544,0.07004557,-0.04148779,-0.061042886,-0.052007284,-0.008271353,-0.09736277,-0.01278196,-0.0069765327,-0.020985939,0.016151197,0.05498444,0.06282519,-0.0045872508,0.010520141,0.042866427,0.027957102,0.024932979,-0.0021861685,-0.041766163,-0.009070528,0.099440955,-0.00797877,-0.04209437,0.04130011,0.01732226,-0.047809716,0.014699099,0.035344053,0.037282605,0.0067929225,-0.06915579,0.014899704,0.10745321,0.030028766,0.10507638,0.046958737,-0.016195957,0.036776062,0.07768746,0.059881773,0.040236715,0.05812127,0.105743006,-0.04496424,0.016713494,-0.05329847,0.07651241,0.00803724,0.014868353,-0.019268366,-0.016083399,-0.04608814,-0.091910556,0.043844398,-0.024019118,0.045906533,0.054757874,-0.007998638,-0.026156204,0.031497672,-0.009735406,-0.027109524,0.037469666,0.07564672,-1.9977723e-08,0.09066985,-0.047100395,0.021396253,-0.09606707,-0.0063670287,-0.0071035447,0.06365685,0.0046283896,0.061157417,-0.0008820098,0.024579087,-0.020273905,0.047039416,0.004775769,0.032485493,0.075822994,-0.01940812,-0.021913694,0.019391755,-0.07981513,-0.04740351,0.001936404,-0.10317189,0.00753118,0.07142017,0.010388294,0.004406259,0.008331364,0.0018802646,0.00193429,0.06103492,-0.033622324,-0.007979489,-0.078628175,-0.0016374547,0.089614056,-0.01480436,-0.025552817,-0.07120053,-0.016167747,-0.08352152,-0.0088831885,0.02011399,-0.038908735,-0.0075784125,0.06274982,-0.060978554,0.019942068,-0.035090562,-0.040864546,0.038964637,-0.0051312405,-0.07638949,-0.080362394,-0.15321009,0.04632519,0.039614286,-0.041317645,-0.012306477,-0.087682545,-0.037958488,-0.054651886,0.07941697,-0.07056297 +2.6.1.40,"The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.",384,1.0,-0.020214664,-0.06515452,-0.08279253,-0.04411167,0.055538584,-0.008906131,-0.063687734,0.07845033,-0.0617771,-0.015401799,0.07581731,-0.12099822,-0.03852671,-0.004110921,0.020901335,0.10872114,-0.12735127,-0.000299871,0.006084837,-0.009789549,0.053275604,-0.029136008,0.0090487,0.022614159,0.06789835,0.065167174,-0.0052358876,0.054488342,0.031920183,-0.031927343,-0.015869897,-0.06019324,-0.03932754,-0.028055007,0.07256777,0.049702577,-0.054862697,-0.017304365,0.016008208,-0.017282426,0.06886416,-0.019921435,-0.039929967,-0.08605246,-0.009861363,-0.036810484,-0.00022783242,0.034892693,-0.008214973,-0.0009874437,0.00424669,-0.08344664,-0.024601508,-0.011161366,-0.026140148,0.08618032,0.037683327,0.054632984,-0.060838204,0.053054616,0.06591048,0.0045751836,-0.040385745,-0.00067236077,0.021648562,-0.057002362,0.07387537,-0.03044988,-0.016273402,0.04399239,-0.07679194,-0.09183103,-0.06639375,0.043187033,-0.01134064,0.017774703,0.02227964,0.0036496501,-0.01520674,-0.055870526,0.066250905,0.018915813,-0.020423096,0.004334634,0.034022857,-0.037812013,-0.0030652306,0.0011157388,0.039701045,0.06393839,0.06100977,-0.011460115,0.0014804373,-0.022301212,0.023157906,0.07589862,-0.040098608,0.06423714,0.0056466903,0.022097485,0.03929083,0.046176754,-0.05293646,-0.066333584,0.02809318,0.038677018,-0.017073546,0.10236879,-0.0345907,0.020903768,-0.017962642,-0.041872233,0.13858584,0.016144384,-0.04090759,0.16410698,0.0081996955,0.0073301625,0.10627657,-0.037959345,0.021698887,0.024307555,0.07631173,0.030061077,-0.046567522,-0.027904687,-0.05101315,-2.0770225e-34,0.07996983,0.008104306,0.021744197,0.027352804,-0.052155595,0.023916379,-0.09394232,0.06425362,-0.022139993,-0.03741014,-0.1238547,-0.03483456,0.05528543,0.025770823,-0.03388498,-0.06640291,-0.014634091,0.1024833,-0.009765309,-0.009173542,0.01963997,0.05089842,-0.03351798,-0.0122948345,-0.06046414,0.00720383,0.012690899,-0.04027219,0.07808351,-0.030433862,0.028607525,-0.039507348,-0.107783645,-0.02152698,0.07025218,-0.005468353,0.033665903,-0.054563466,0.035099808,0.08004099,0.051899344,0.053759865,0.038872886,-0.016950032,0.04756421,-0.018994184,-0.022666477,0.06884154,0.076804325,-0.008398021,0.054005597,-0.03535095,0.049246874,-0.0057163876,0.0011795507,-0.018258952,-0.0014345421,0.018266164,0.064159885,-0.011744554,-0.06940657,0.017105423,0.041196283,-0.021607712,0.005114364,0.00038932875,-0.10847011,-0.025632534,-0.0749957,-0.006271951,-0.09244899,-0.003133994,0.046137135,0.04552022,0.028089339,-0.12211426,-0.09148379,-0.026286215,-0.054355867,-0.024543853,-0.013415799,0.034299992,-0.029921776,-0.016041836,-0.017058318,-0.01577169,-0.010414183,-0.05545506,0.02432585,0.045619316,0.032609556,0.011005458,-0.10081581,0.05246165,0.015550434,-2.7125946e-34,0.04456599,-0.08903869,0.01033735,-0.025117967,-0.068867765,0.047358725,0.017646624,0.015004527,-0.04148332,0.0064494745,0.10228808,0.035922,0.108729236,-0.119101256,0.029256603,-0.06161816,-0.022686541,0.09714547,0.044688046,-0.021716166,0.055369534,0.0073024067,-0.007468944,0.012901964,0.046500377,0.033080652,-0.043558612,0.027212705,0.057151668,0.044584572,-0.05448814,-0.055883866,-0.016245652,0.053499516,-0.05120687,0.115647756,-0.028693706,-0.04645772,-0.01941973,0.037990056,-0.08507723,0.062071137,-0.021007854,0.05896034,0.036952104,0.021474112,-0.060867738,-0.011808374,-0.061156835,-0.03365496,0.040085085,-0.022403536,-0.047405373,-0.010178473,0.01660535,-0.022093093,-0.02240634,0.018298952,-0.0512163,0.008157665,0.011410093,0.0033559098,0.015763812,-0.103970386,0.069492884,0.06764534,-0.01913101,0.06439937,0.045139603,-0.03556685,0.022239394,-0.020068055,0.003535952,-0.008441063,0.059313774,-0.053064447,-0.014429041,-0.07627864,-0.044650838,-0.12740469,-0.06607301,0.00073272194,0.0660494,-0.037189893,-0.04292358,-0.026787294,0.04151434,0.09088933,-0.042783085,0.026319852,-0.014051776,0.019354368,-0.03179916,0.16324656,0.088674456,-4.0493582e-08,0.05398198,-0.0452485,0.047938004,-0.018710978,-0.038054045,0.050900526,0.014764911,-0.020615432,0.035289716,-0.08604559,-0.012919021,0.027630372,0.015188207,0.029877288,0.06742151,0.014711375,-0.01836122,0.075754784,-0.067062855,-0.026201136,-0.06067899,-0.030254446,-0.08834803,-0.020235423,0.045358058,0.00291356,-0.017857956,0.0845817,-0.015335202,0.036573317,0.008505466,-0.041905668,0.02509437,0.017066881,-0.02947863,0.078226246,-0.100830905,-0.007473642,-0.067639776,-0.05391005,0.0016772405,-0.044210996,-0.09916191,0.040501468,0.062709704,-0.011905008,0.038792104,0.090883255,-0.004214998,0.0013670913,0.049255442,-0.03190115,0.012980033,-0.056655042,-0.08421163,0.00881544,-0.05845339,0.014745002,0.03098205,-0.036778457,-0.0070788558,0.025134537,0.12640066,-0.038301863 +2.6.1.41,Oxaloacetate can replace pyruvate.,384,1.0,-0.03651754,0.03624796,-0.057267133,0.033725083,0.03023407,0.0011827875,-0.04937473,0.05944472,0.007280913,-0.0138118435,-0.039579928,0.029715044,-0.109727934,0.051545665,0.0007146789,0.0455936,-0.0013279652,-0.021020122,0.07860319,-0.0007404922,0.07423515,0.049649354,0.07112925,0.0033014538,0.030359587,0.0420884,0.014493154,0.067753464,-0.00074806,-0.0194296,-0.03870432,0.004100507,-0.019206965,-0.08022499,0.016475035,0.13679409,-0.07432072,0.024995653,0.0029899732,-0.023550766,0.07408008,0.015312597,-0.0682627,-0.008127741,-0.019815302,0.019347178,0.019438382,-0.0121610295,-0.040742703,0.03503161,-0.020965878,-0.009655564,-0.10379831,0.042848747,0.026430693,0.011753182,0.0058272686,0.0071825567,-0.06083219,-0.09378381,-0.01756286,-0.014449296,-0.0013216445,-0.006404254,-0.043761276,-0.03550107,0.07277673,-0.055865344,0.0032330095,-0.049023468,-0.120160446,-0.02338928,0.11936662,-0.009765026,-0.025032012,0.007807428,0.04894938,-0.062979795,-0.0042745094,0.04566422,0.022247156,0.011747205,-0.064821824,-0.0012242805,0.038244635,0.010386793,0.007158252,-0.105293155,-0.035212558,0.03004826,-0.054620307,0.04305432,0.026551073,0.019909702,-0.041982383,-0.010564331,0.063718826,0.04454853,0.023751672,-0.026837893,0.01733074,0.08389383,-0.07655653,-0.097485155,-0.065822884,0.007420552,0.00038692093,0.021256143,0.072393134,0.011372763,0.02609937,0.098016545,0.048967578,0.03661963,-0.026159557,0.08176201,-0.014831165,-0.032832544,-0.09997227,0.064825386,0.012411342,-0.055751033,0.033919033,-0.0030748793,-0.08178714,-0.044477932,-0.033274863,2.0268998e-33,0.033501856,0.022815667,0.0031553935,0.01253518,0.047202844,0.044415563,-0.0943897,-0.05679923,0.06556926,-0.050396893,-0.07616193,-0.059412923,0.015321907,0.002792199,-0.10238357,-0.06074133,-0.08180238,0.020057695,0.07301375,-0.057515603,0.03136708,0.046673052,0.027404314,0.03441549,-0.024820415,0.061043918,0.02086305,0.05385729,-0.047423832,-0.041794427,0.0776886,-0.0768915,-0.052027717,-0.009904442,-0.034556344,-0.065578535,-0.0484258,-0.10341235,-0.0031542056,-0.002324267,-0.035768908,0.038129374,0.007306799,0.04969532,0.035455655,-0.064901546,0.014228542,0.12974522,-0.024570681,0.045102287,-0.016785944,-0.010663705,0.057506,-0.06064698,-0.068753004,-0.019169107,-0.020808065,-0.0074561276,0.09094271,0.025717096,0.0745437,0.09225163,0.058896404,0.029842824,-0.04601293,0.012639089,-0.03131106,-0.038678367,-0.057177283,0.05920156,-0.02524906,-0.047503654,0.027375659,0.047762293,-0.00813939,-0.049509857,-0.04606529,0.07085047,-0.009028315,-0.07948999,-0.0023219492,-0.06445338,0.015759997,0.025703935,-0.02245965,-0.011801069,-0.046333995,0.0136917075,0.07079653,0.057372786,0.042781375,-0.02282334,0.010126175,-0.04929114,0.045094512,-1.8966609e-33,0.08113565,-0.088761225,0.023346167,-0.042526755,0.0056341453,0.008986236,0.022417078,-0.02669195,-0.019847317,-0.04362404,-0.007422629,-0.003755765,0.038326822,-0.0297161,0.04541086,0.043101422,0.03274626,0.024703337,-0.030787189,0.02166237,0.020268433,0.058577903,-0.10568831,0.047446236,0.042466078,0.062787294,0.013270097,-0.0052811857,0.031370685,-0.027260866,0.018459274,-0.016370999,-0.09938573,-0.014700739,-0.0039391164,0.02447016,-0.015364982,-0.055948697,-0.07820753,0.022819446,0.05591311,0.03628861,0.019373862,0.09370202,0.0044681267,0.025883978,-0.09093666,-0.07635495,0.019942842,0.047812335,0.035838693,0.048648756,-0.07685941,-0.081801444,0.09554558,0.023057606,-0.007233959,-0.08011039,0.019335696,-0.0648204,-0.035851687,-0.0804665,0.05122491,0.008912235,0.056730762,0.0668183,0.059613913,-0.011391696,0.06995886,0.085996196,0.11129585,0.044155013,-0.08308519,-0.0781066,-0.008644778,0.028156837,0.0067264084,0.0238905,0.0027576273,-0.04269666,-0.024721337,-0.048398945,0.03768722,-0.09749677,-0.0038428884,-0.033694085,-0.01277702,0.09175649,-0.03457562,-0.00014748963,0.03327347,-0.08970941,-0.029560978,-9.077197e-05,0.09771308,-1.8736515e-08,-0.03333017,-0.035367,0.08712769,0.074681714,-0.030128185,-0.055959422,0.02507232,0.04867238,0.031560246,-0.039896086,0.035808712,0.07377803,0.15485498,-0.022073837,0.032234807,-0.015306573,-0.015545168,0.09080187,-0.032528024,0.025803901,-0.13139753,-0.0046927193,-0.10100014,0.08330159,0.06460847,-0.03291284,0.029749619,0.033877,0.008987505,-0.051340707,0.035793465,0.006385656,0.050658673,-0.064824715,-0.030646818,-0.041776255,0.047126465,0.035654824,-0.0267717,-0.025367111,-0.040689748,-0.059524763,-0.012158638,0.06601515,-0.021834657,-0.0053624273,-0.016193368,-0.024233354,-0.037092652,-0.013836327,0.118685104,0.02175046,-0.021162441,-0.022781515,-0.05835868,0.042116094,0.02417287,0.004843617,-0.045138527,-0.029601147,0.059823688,-0.017335843,0.14144623,-0.089191735 +2.6.1.42,"Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase.",384,0.99999994,-0.028921602,-0.091020845,-0.024565749,-0.013023958,0.039499965,0.029936958,-0.11150113,0.06596876,0.04665961,-0.06796551,0.040656637,-0.002792297,-0.07072324,0.0056175357,0.03635254,-0.03030382,-0.05652712,-0.013963555,-0.042057827,-0.019183688,0.06811127,0.017854236,-0.023883533,0.014201831,0.067090906,-0.014207489,-0.015229753,0.039385244,0.07726227,-0.048448294,0.0073447344,-0.013719973,-0.04147029,-0.08450075,-0.0008937455,0.035980247,-0.049286097,-0.01740833,-0.038278658,0.023414092,0.02325794,-0.045505207,-0.040428694,-0.037790537,0.036227778,0.008761628,-0.047837608,-0.010737114,-0.07141874,0.00045464808,0.028742954,-0.06222023,-0.0495014,0.04302342,-0.0384,0.057414748,-0.09838867,0.053192377,0.0072672274,0.008825658,-0.061919387,0.06428588,0.029208435,-0.011315932,-0.010663364,-0.03647155,0.0837498,-0.090313025,0.0113684945,-0.090090506,-0.09632336,-0.069539525,0.031092182,0.07055261,0.0008054949,0.025349712,-0.045388237,0.037282504,-0.05704797,-0.08053137,-0.018611051,-0.06178206,-0.075533405,-0.039148465,-0.05631364,-0.03191593,0.008596013,-0.010417859,-0.02720252,0.041826457,0.10064296,0.0024527765,0.0053924704,0.0125929965,0.004110791,0.025652686,-0.014212028,0.13179055,0.058541838,-0.07505247,-0.026398774,0.089057796,-0.15963498,0.009643341,0.022370316,-0.024352564,0.025760455,0.04113454,-0.005292481,-0.073013104,0.035023484,0.0019089363,0.043855682,-0.028434709,0.0060253534,0.031031419,0.046436746,-0.029685762,0.035708547,0.06503302,0.06532719,-0.050931264,0.11655791,0.06394446,-0.05691631,0.023217862,-0.04101036,-1.0562607e-33,0.033043005,-0.00821789,0.065135896,0.0036640868,-0.047273345,0.03982108,-0.12348799,0.07525404,-0.0018433058,-0.09166458,-0.09948501,0.03554568,0.06275194,0.03453945,0.03218819,-0.00828646,0.025231471,-0.050745863,0.040099647,-0.06007704,0.07630174,0.07373837,0.04295252,0.06960644,0.02315653,-0.0010290791,0.042059753,0.017286418,-0.06955019,-0.004293183,-0.049822528,-0.10126939,0.0696386,0.01485496,-0.005748859,0.09607025,-0.016084148,-0.0154436,-0.035573978,0.008904743,0.034585048,0.03848803,0.010509797,-0.01706842,0.057507217,-0.050352585,0.0053871577,0.04237103,0.0031536692,-0.024337102,0.006617567,-0.0064853854,0.052840397,-0.051278453,0.037110582,-0.004053981,-0.00038723036,0.06720611,-0.001867846,0.09956335,0.05633272,0.15227939,0.017619781,0.030851241,-0.02849629,0.04555909,-0.10147123,-0.047862943,-0.10590426,0.028369492,-0.11273019,0.039539736,0.07167911,0.03349269,0.06905578,-0.07245729,-0.095048584,0.004833196,-0.03605564,-0.07037677,-0.07649128,0.0010624918,0.047123358,-0.005205681,-0.022704603,-0.04534585,0.0038994274,-0.01704808,0.04313661,0.036583956,0.024869183,0.031681325,-0.02956247,0.037926413,0.07869806,-1.31495105e-33,0.012550236,-0.060601246,-0.0065607796,0.010527181,0.045261316,0.05337797,0.043031853,-0.0342118,0.022770789,-0.047514156,0.06986611,-0.037038334,-0.047395434,-0.07583617,0.04594233,-0.082773425,-0.038364846,0.010223852,0.02601824,0.06393608,-0.06563146,0.047709778,-0.078857325,-0.005459937,0.04931394,0.008523318,0.028768905,0.039252266,0.06626262,-0.02108215,-0.00675624,-0.0018152923,-0.0046675326,-0.03673881,-0.046247926,0.06126049,-0.02415526,-0.026918273,0.0005569697,-0.018811462,-0.011848219,0.0091958875,0.039508168,-0.017484942,0.033138312,0.029212365,0.0074060727,-0.054132126,-0.050128657,-0.043967713,0.08451554,-0.068152085,-0.027143275,0.053368215,0.05249765,-0.03284406,-0.03698916,0.024096677,0.00021746644,-0.010676078,0.05770018,-0.044613674,0.013176671,-0.028301202,0.025553897,-0.003818272,-0.0029887133,0.019726787,0.016637713,0.030844443,0.055174615,-0.07958101,-0.065067545,-0.03136838,-0.07251658,-0.035392325,0.016451186,-0.022233995,0.0033532858,-0.09802418,-0.0049272776,-0.001173801,0.0017473124,-0.05620639,0.0005373956,0.048983477,-0.031178426,0.055432547,-0.018602537,-0.0052084248,-0.015286044,-0.038114,-0.071529485,0.012712785,0.09520025,-3.5599207e-08,0.06974477,-0.038194064,-0.002271054,0.041092154,0.040081028,-0.035762526,-0.0018127903,0.0055820937,-0.019788954,0.001001878,-0.015039105,0.017277138,0.068164036,-0.10669092,0.028906533,0.04956456,-0.049611825,0.11696317,0.030661503,0.09606025,-0.059197042,-0.04812401,-0.10153342,-0.06395578,0.011689401,-0.08270586,-0.013262866,0.03364385,0.0670957,-0.098589264,0.12002216,-0.018188994,0.08796076,-0.037897527,-0.0027913784,0.024756439,-0.016187388,-0.00027165562,-0.013952808,0.06529151,0.011275533,-0.11174348,-0.067364536,0.040999703,0.018909732,-0.011979872,0.06365852,-0.022583153,-0.010094989,-0.0009652715,0.037892073,-0.068154775,0.012422113,-0.061873704,0.033871967,0.05765151,-0.0027190545,-0.07539232,0.08190763,-0.06734186,0.0890281,-0.010282135,0.12882036,0.044926282 +2.6.1.43,A pyridoxal-phosphate protein.,384,0.99999994,-0.027926307,-0.082669966,-0.06864404,-0.0736116,0.027612139,0.00069278304,0.043136388,-0.0022198383,0.07759752,0.061581366,0.050052542,0.024383662,-0.07972978,0.075630225,-0.018062996,0.011146767,-0.058814332,0.026981099,0.028646505,-0.060484987,0.08062581,0.046058796,0.013964545,-0.0034948976,-0.022635197,0.09317548,0.03897881,0.08481283,-0.022757838,-0.06512055,-0.033645604,-0.002438178,-0.04265655,-0.081326276,0.049699727,0.09206192,-0.10426549,0.024624566,0.01641356,-0.038264256,0.09138554,-0.06995117,-0.019178458,0.015225969,-0.079754055,-0.009005391,0.060174454,0.06121611,0.1076781,-0.0044863066,-0.08720911,-0.014019634,-0.013987518,-0.049955927,0.010103739,0.04439458,0.025756652,0.03877331,-0.030249724,-0.031439897,-0.018875996,-0.014899653,0.033183742,0.03005634,0.045147188,-0.03863779,0.011696549,-0.046883464,-0.028674698,-0.0040879943,-0.0399809,-0.0017529497,0.12130531,0.0010538863,-0.034636367,0.09728037,-0.028074443,-0.023704544,-0.04040873,0.055432733,0.03498061,0.00886843,0.038521856,0.08173242,0.056242175,0.02956211,0.015032759,-0.008670652,-0.0671204,-0.03498028,0.0024070852,0.025017837,0.033844747,0.03431295,-0.017365431,0.020294111,0.0095834825,-0.017277373,-0.049156386,-0.05037137,-0.0135520855,0.006560372,0.029906176,-0.04925029,-0.040218767,-0.005961301,-0.070319004,0.04136831,-0.008511003,-0.0040058997,-0.05803713,0.0810462,-0.012979407,0.006107804,0.023426063,0.022639925,0.016739301,-0.004660274,-0.05652102,0.057704583,0.0031750596,-0.032194667,-0.030190036,0.08859248,-0.054773755,-0.0542106,-0.07686096,-2.4678308e-33,0.06313784,0.074121,0.050783433,0.040298108,-0.011358971,-0.014224093,-0.06284932,-0.054584622,-0.06972202,-0.006010194,-0.005837788,-0.041249312,0.07401363,0.007710753,-0.07779482,-0.03148981,-0.09894455,0.03780528,0.09449977,-0.054316152,0.036347546,0.122786574,0.015729465,0.06573166,-0.023447253,0.10535222,-0.04718892,-0.017551308,-0.020911029,-0.010473525,0.017130276,-0.08890346,-0.10486213,-0.037216794,0.029635139,-0.1032107,-0.053137314,-0.088244945,-0.028490026,0.010690034,-0.031340834,-0.06654564,-0.015844474,0.03225437,0.005228752,-0.12502499,-0.022130616,0.049036965,-0.04441586,0.030425001,0.03924025,-0.065284304,0.07721513,-0.0022649365,-0.14055419,-0.054724984,-0.056979842,-0.04121839,-0.0039615375,0.036306877,0.055933136,-0.0074688112,-0.0776967,0.005927369,-0.007340223,-0.05244896,0.01644481,-0.06923204,0.06292541,0.08146769,0.070626065,-0.021183291,0.08123207,0.022367109,-0.017924992,-0.0069551063,-0.03999482,0.04453336,-0.028805178,0.099463925,-0.02261902,-0.0688775,-0.055661384,-0.03151839,-0.050702408,0.0006394455,0.025497343,-0.05753736,0.047344767,0.00027531275,0.030769043,-0.11320937,-0.0680435,0.018650109,-0.030141242,3.6575068e-34,0.07618561,-0.056287874,0.10101466,0.007109189,-0.055663213,-0.0030681002,0.0774277,0.02046836,0.023406582,0.0041982206,0.0350583,-0.0105334455,0.015140504,-0.066251345,-0.004752528,0.054859713,-0.009271968,-0.005652817,0.058509693,0.04026011,-0.003693155,0.011792269,0.016480174,0.09651126,0.053761203,0.075716525,0.01452238,-0.0019530556,-0.07552723,0.029911192,0.030482544,0.07004557,-0.04148779,-0.061042886,-0.052007284,-0.008271353,-0.09736277,-0.01278196,-0.0069765327,-0.020985939,0.016151197,0.05498444,0.06282519,-0.0045872508,0.010520141,0.042866427,0.027957102,0.024932979,-0.0021861685,-0.041766163,-0.009070528,0.099440955,-0.00797877,-0.04209437,0.04130011,0.01732226,-0.047809716,0.014699099,0.035344053,0.037282605,0.0067929225,-0.06915579,0.014899704,0.10745321,0.030028766,0.10507638,0.046958737,-0.016195957,0.036776062,0.07768746,0.059881773,0.040236715,0.05812127,0.105743006,-0.04496424,0.016713494,-0.05329847,0.07651241,0.00803724,0.014868353,-0.019268366,-0.016083399,-0.04608814,-0.091910556,0.043844398,-0.024019118,0.045906533,0.054757874,-0.007998638,-0.026156204,0.031497672,-0.009735406,-0.027109524,0.037469666,0.07564672,-1.9977723e-08,0.09066985,-0.047100395,0.021396253,-0.09606707,-0.0063670287,-0.0071035447,0.06365685,0.0046283896,0.061157417,-0.0008820098,0.024579087,-0.020273905,0.047039416,0.004775769,0.032485493,0.075822994,-0.01940812,-0.021913694,0.019391755,-0.07981513,-0.04740351,0.001936404,-0.10317189,0.00753118,0.07142017,0.010388294,0.004406259,0.008331364,0.0018802646,0.00193429,0.06103492,-0.033622324,-0.007979489,-0.078628175,-0.0016374547,0.089614056,-0.01480436,-0.025552817,-0.07120053,-0.016167747,-0.08352152,-0.0088831885,0.02011399,-0.038908735,-0.0075784125,0.06274982,-0.060978554,0.019942068,-0.035090562,-0.040864546,0.038964637,-0.0051312405,-0.07638949,-0.080362394,-0.15321009,0.04632519,0.039614286,-0.041317645,-0.012306477,-0.087682545,-0.037958488,-0.054651886,0.07941697,-0.07056297 +2.6.1.44,"A pyridoxal-phosphate protein. With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. A second component also catalyses the reaction of EC 2.6.1.51 serine---pyruvate 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+2.6.1.45,A pyridoxal-phosphate 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+2.6.1.50,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.51,A pyridoxal-phosphate protein. The liver enzyme may be identical with EC 2.6.1.44 alanine-glyoxylate transaminase.,384,1.0,-0.02534262,-0.057600956,-0.04613242,-0.047828868,0.033359203,0.0044380273,-0.070029885,0.04785312,0.01824759,-0.001286779,0.040892363,-0.02015253,-0.09644935,0.04555377,0.015944444,-0.018226761,-0.058326297,-0.02785858,0.008280336,-0.072022304,0.07001236,0.019274801,-0.015496663,-0.035303574,0.059227526,0.0865151,0.06138301,0.08181301,0.058991708,-0.07204867,-0.028174965,-0.06102268,-0.004440152,-0.061862726,0.035320915,0.08095814,-0.08120002,-0.021204544,-0.02125371,-0.048524644,0.058328163,-0.0037925711,-0.013888322,-0.060327094,-0.051850647,-0.022432033,0.040411536,0.011093412,0.050686363,0.017822504,0.0009481072,-0.07161521,-0.006218865,-0.069415174,0.05400891,0.063985065,-0.025057176,0.017815417,-0.020213667,-0.03750108,-0.055219587,-0.013989786,0.047583874,-0.006793353,0.052923154,-0.0013916515,0.04681533,-0.073194034,-0.02727006,-0.07423005,-0.093935266,-0.09367801,0.07745654,0.044123605,-0.07182545,0.06766131,-0.06943535,-0.015383699,-0.007422183,0.060506117,-0.018106127,-0.08686874,-0.015426171,0.033549268,-0.017648302,-0.0020234163,0.013229178,0.012883433,-0.05150743,-0.0060357614,0.045734312,-0.014447298,0.07052494,-0.008544261,0.0014843654,0.059711248,-0.039174467,0.06307135,-0.0045984876,-0.074730285,0.013526256,0.11372095,-0.047235616,-0.015902197,-0.018678917,0.012955033,-0.056557138,0.09596432,0.032772716,-0.045708694,-0.045359515,0.026341775,0.04420129,0.005183298,0.028196905,0.096215226,-0.0006718397,0.003332224,-0.013935003,0.08996686,0.033524256,0.021043666,0.091580264,0.08547138,0.001206684,0.0003816803,-0.030908551,5.3127087e-34,0.08154523,0.09302511,0.06476524,0.011543192,-0.022975238,-0.016522791,-0.09505332,0.11175009,-0.018214071,-0.07020433,-0.078657694,0.0080538895,0.0742568,-0.010785619,-0.035531465,3.097915e-05,-0.047912464,0.010976113,0.080739014,-0.017881854,0.051627215,0.016782522,0.025249787,0.075029165,0.05917587,0.04886798,-0.023353258,0.008293819,0.011964361,0.0088896295,-0.047879394,-0.09247836,-0.07212956,0.00841467,-0.015863966,-0.02464686,-0.012254282,-0.050512537,-0.04362585,0.048667673,0.025493871,-0.06294215,0.020901619,-0.024517229,0.04046482,-0.13797568,-0.06276692,0.03966124,0.024036411,0.068239704,0.032792043,-0.04187036,0.10178547,-0.037852634,-0.031150697,-0.0491053,-0.03712174,0.042701438,0.009610069,0.08167902,0.10811389,0.07555021,-0.051455084,0.0388776,-0.019023912,0.018486928,-0.0636271,-0.079559505,-0.06735726,0.0969211,-0.00233708,0.013883617,0.09477128,0.051940046,0.0046268753,-0.08484076,-0.061692975,0.032016844,-0.027755793,0.035630517,-0.09404244,-0.009272271,-0.041959453,-0.061982915,-0.03465028,-0.032459542,0.047171976,-0.052844934,-0.004028585,0.027704995,0.01646116,-0.07135391,-0.1258517,0.04857852,0.014201005,-1.7825108e-33,0.072457835,-0.094446674,0.033370536,-0.021695882,-0.017704515,-0.001366371,0.09014124,0.016804382,0.042749155,-0.024220131,0.09817772,0.0027282282,0.027121348,-0.08700185,0.021404527,-0.026823515,-0.04236246,0.035368938,0.091399856,0.024765441,-0.0049523963,0.03166366,0.015960023,0.022089537,0.08791022,0.032851797,0.024005909,-0.022502666,0.012032862,0.020136151,-0.03074368,0.074307784,-0.0071720188,0.008216351,-0.063725226,0.07500086,-0.078373805,-0.023392621,0.009378731,-0.011231102,0.0042799762,0.118520826,0.0013773738,0.041450057,0.025695331,0.05602044,-0.023489809,-0.024111403,0.009942076,-0.081212424,0.018503772,0.04583379,-0.009925954,0.07595433,0.006159236,0.0071019973,-0.050209317,0.07172682,-0.0070252935,0.0048975414,-0.0147751495,-0.044984795,0.012367848,0.048022497,0.031362385,0.026647262,-0.004886777,0.030327043,-0.012197968,0.058026526,0.051378462,-0.085733145,-0.0094264485,0.10027682,-0.028345749,-0.018828304,-0.011693418,0.06183779,0.012911615,-0.11137064,0.0076248627,0.0021696477,0.0024930355,-0.029377233,0.04057505,-0.008599638,-0.022372317,0.10270369,0.020074448,0.020827763,-0.031100428,-0.0024544145,-0.11289694,0.022358343,0.054424535,-3.3484167e-08,0.053881235,-0.0683593,0.009668145,-0.032786697,0.05264909,0.035382774,0.016248336,-0.02852897,0.0035123369,-0.040194698,-0.017443778,0.03739674,-0.029087638,-0.060332473,0.008359346,0.08989832,-0.12090549,0.04686243,0.036366217,0.022187715,-0.06781787,-0.019322054,-0.09826409,0.011579226,0.011195358,0.01578284,-0.018827261,0.020829909,-0.013404796,-0.0055168457,0.014119398,-0.026023667,0.023451198,-0.041046776,-0.0618203,0.022896515,-0.007543362,-0.009579383,-0.08549493,0.025511527,0.0034865215,-0.12313584,-0.063734494,-0.05370982,0.049349625,0.050383046,0.013122392,0.007481563,-0.0065929242,-0.047076754,0.03179998,-0.046737064,-0.027737513,-0.08084879,-0.10538323,0.011527815,0.011970413,-0.091851264,0.010757021,-0.07941867,0.040456213,0.04592062,0.15032163,-0.06566683 +2.6.1.52,"A pyridoxal 5'-phosphate protein. This enzyme catalyses the second step in the phosphorylated pathway of serine biosynthesis [1,3] and the third step in pyridoxal 5'-phosphate biosynthesis in the bacterium Escherichia coli [3]. Pyridoxal 5'-phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis [4]. Non-phosphorylated forms of serine and threonine are not substrates [4]. The archaeal enzyme has a relaxed specificity and can act on L-cysteate and L-alanine as alternative substrates to O-phospho-L-serine [7].",384,1.0,-0.023590866,-0.08099522,-0.069187015,-0.084488705,0.083422735,0.062273018,-0.06316402,-0.02316012,0.09024799,0.038934186,-0.03870096,0.03967696,-0.052040488,0.029774433,-0.009878396,-0.0035360442,-0.09316229,0.048338246,0.009710252,-0.039939582,0.15091357,0.034764986,-0.022571338,0.00088708464,-0.01861061,0.045447987,0.035371132,-0.018070102,-0.05886598,-0.04738164,-0.050706092,-0.013875822,0.006552631,-0.093867265,0.048065376,0.09754391,-0.056602076,-0.022474188,0.06106384,-0.042620506,0.06084157,-0.03890229,-0.020861123,-0.0019416597,-0.0961862,0.002627924,0.08122021,-0.019828197,0.027507227,-0.048559934,-0.11739554,-0.005266048,-0.038279466,-0.047955867,-0.027938155,0.06207264,0.020381888,-0.05003298,0.009253575,-0.0987625,-0.008139298,-0.016175108,0.043529727,-0.0082889395,-0.004018607,-0.038343213,-0.0060310736,-0.061631817,-0.015122133,-0.02543171,-0.091571465,-0.03890739,0.077905804,0.034713767,-0.01993161,0.0990033,-0.0032767348,0.018555686,-0.031233024,-0.0066141104,0.041121535,-0.010687214,-0.0064664427,0.05359858,0.033527058,-0.032380335,0.0059150727,0.028718326,0.09951179,0.0029983027,0.051765054,-0.019770378,0.041707907,-0.034855198,0.0026150863,-0.010997359,0.008540519,0.02473633,-0.0503089,-0.0695507,0.0036919955,0.03253595,-0.025074484,-0.012351135,-0.039993983,-0.023765322,-0.020712748,0.103239805,-0.014972085,-0.04040475,-0.0394134,-0.014575473,0.02246688,0.019096114,-0.026179967,0.040355474,0.041520536,-0.07464099,-0.07608724,0.011843935,0.005573575,-0.024510931,0.09137758,0.10102483,-0.0663681,0.023024093,-0.13294588,3.989673e-33,0.07786286,0.07152558,0.058258828,-0.06491557,0.05418046,-0.04823422,-0.06479651,-0.032581486,0.025926279,-0.027788764,-0.030471206,-0.06489069,0.079213195,-0.06440567,-0.05701895,-0.009998579,-0.06302029,0.07370758,0.072134994,0.039262146,0.022231251,0.05891873,0.020689989,0.064020224,-0.0012058903,0.057580836,-0.0012349007,-0.017391017,0.006033454,0.0029917366,0.020099025,-0.1058477,-0.054358367,-0.037950158,0.13248473,-0.05505656,-0.051976424,-0.006497937,-0.059964895,0.015520916,-0.03622566,-0.0091569545,-0.023985904,0.032645572,0.021687202,-0.07560195,-0.06865812,0.110365346,-0.008511694,0.06826908,0.020909445,-0.06255311,0.075035125,0.012957598,-0.12381097,-0.026151577,-0.042628888,-0.023990197,0.036089975,0.038696207,0.040158093,0.02018549,-0.010163199,0.023112383,-0.0041374303,0.01364513,0.0031700993,-0.0378535,0.037227206,0.13740714,0.020477619,0.015464022,0.05107763,0.074279204,0.025726737,-0.020069275,-0.07590098,-0.0067263097,-0.024229908,0.041089747,0.021288872,-0.048245944,-0.045302063,0.03279579,-0.010792406,0.02030891,-0.008308641,-0.03710919,0.011781716,0.06552567,0.035134528,-0.10906989,0.00348006,0.05837756,-0.042079292,-4.8398287e-33,0.07104984,-0.09638024,0.07874575,-0.062180206,-0.09326541,0.039241295,0.016090032,-0.021754188,0.011926543,-0.012012732,0.031329643,0.006370483,0.050294224,-0.028395105,-0.033938114,-0.06690014,0.050099444,0.02648635,0.06220003,0.04816435,0.07415738,-0.00763455,-0.024740713,0.043264538,0.09757894,0.04815917,-0.0077412333,0.07980478,-0.056303356,0.016449789,0.030874552,0.09201185,0.0014760285,-0.09960815,-0.068430245,0.040224914,-0.075228505,0.009359527,0.05388507,0.018307246,0.004176077,0.057867996,0.059465114,-0.00097591174,-0.019728981,0.0026892247,-0.051224306,0.02811667,0.022686213,-0.051787946,-0.0045275674,-0.01146824,-0.029634964,-0.05182682,0.01568074,0.04907337,-0.015231126,0.06751753,0.014076413,0.0038521425,-0.009661616,-0.082419254,0.0013381451,0.018442541,0.05467947,0.029084476,-0.0019225186,0.040310428,0.0087511325,0.02961377,0.0063840467,0.028615464,0.06056391,0.11941971,0.015850406,-0.0054829926,-0.024527729,0.0026436714,0.039703935,-0.009448941,-0.06585715,-0.013997537,-0.0067588305,-0.117049575,-0.029563691,-0.05532034,0.108417965,0.098201744,-0.00063651596,0.018507276,-0.022301266,-0.0635141,-0.026602417,0.04498913,0.035059046,-4.1670127e-08,0.06783587,-0.057507366,0.013120674,-0.009541695,-0.030933741,0.012597666,0.023281518,-0.02235966,0.07198518,-0.070090495,0.023311254,-0.019265007,0.04196586,0.00060400314,0.042170554,0.06491886,-0.05927948,0.003064092,0.0037503133,-0.067570224,-0.031026857,-0.003061793,-0.11399601,0.021935616,0.12055465,-0.04092861,0.011692904,-0.00853351,-0.047218207,-0.065804325,0.0187189,-0.033865884,0.014236285,-0.06340846,-0.03653729,0.031713404,-0.07902768,-0.04344703,-0.0109964935,0.028517498,-0.07449805,-0.008825913,-0.06472934,0.015151688,0.018609678,0.09810157,-0.045030367,0.033703286,-0.08788253,-0.05519107,0.04630534,-0.022723753,0.022668535,-0.067086145,-0.089772075,0.04618962,0.057846073,-0.074079745,-0.026532963,-0.033982813,0.031922314,0.009560071,0.11720226,-0.07613216 +2.6.1.54,"Also acts, more slowly, on pyridoxamine.",384,0.99999994,0.06209297,-0.13560282,-0.016904568,0.02014436,0.04514357,-0.011126235,0.034896508,0.05590279,0.04617943,0.0073175677,0.03743132,0.022443501,-0.054925468,0.12534253,0.026457343,0.05550959,0.0020837234,-0.010652925,-0.001183095,0.032729954,0.047809787,-0.028256688,0.07474003,0.006303043,-0.07906161,0.09072442,-0.019788925,0.035740666,0.015874438,-0.08295668,-0.010251515,0.08726933,-0.026240326,-0.042171735,-0.00058361155,0.07989276,-0.098144256,0.08675359,-0.011143801,0.0023579004,0.06718977,-0.07313973,0.0067009735,-0.017624225,-0.0348959,0.016527018,0.05007969,-0.039005242,0.035564575,0.021086933,-0.03633393,-0.03915822,-0.008835684,0.011053114,-0.03335489,-0.00067408837,-0.07081657,0.039879385,-0.004185123,-0.05324546,-0.07978577,0.04086328,-0.013698414,0.03131854,0.049241953,0.017726818,0.050308317,-0.06641286,0.005895747,0.018360991,0.058227178,0.03021685,0.027079456,-0.043156806,-0.01655886,-0.04958303,-0.0005695289,-0.09039614,-0.04830548,0.014799024,-0.072664686,0.00011455266,-0.009070944,0.016394027,0.029449113,0.049447786,0.03658188,-0.09977181,-0.10884565,0.023521837,0.020709634,0.031631567,-0.03918591,0.046262812,-0.02350909,-0.0075915274,0.005972603,0.030682756,-0.032987587,-0.021522868,-0.024125397,0.008896049,-0.10202255,-0.031254865,-0.023602938,-0.01734187,0.054233283,-0.010256785,-0.04083338,0.0801203,-0.04650124,0.020952178,-0.021672666,0.09397518,0.0074073137,0.07378148,0.0032268686,0.016819783,-0.08330429,0.022953562,0.054279298,-0.0322206,-0.022858191,0.035709854,-0.01199936,0.0072070113,-0.019888751,-4.9353218e-34,0.006501192,0.008601131,0.010758155,-0.020754267,0.013483671,0.03682101,-0.07103051,-0.029716592,0.02411402,-0.010627653,-0.03719797,-0.033253856,0.020741343,0.08603653,-0.07139893,-0.11191263,-0.056793682,0.025736103,0.04013992,-0.07905068,0.05158974,0.07821024,-0.056973238,0.055454925,-0.04578653,0.043498572,-0.029702153,0.06194933,-0.045922577,-0.020959653,0.03804647,-0.037774466,-0.070644654,0.010848096,0.027527295,0.09463861,-0.040747337,-0.004047955,-0.03220328,-0.012146968,-0.05820064,0.02487166,-0.11076035,0.0023700567,0.01693647,-0.07241505,-0.092349574,0.08754218,-0.005585096,0.04043582,0.06844712,-0.0318772,0.10135646,-0.022976115,-0.027568381,0.015844762,0.020165015,-0.08187784,-0.026518866,0.052325398,0.054433305,0.044663448,-0.017176125,0.004418159,-0.009178725,-0.0063761594,0.006189371,-0.02019724,0.02649986,0.011265944,-0.04954953,0.012415722,0.09284172,-0.0059467903,-0.004014161,-0.05208582,-0.057666812,-0.028158437,-0.01689613,0.00082481554,-0.008406819,-0.11792652,0.019709354,-0.008126391,-0.030542398,-0.011678203,0.024677582,-0.076309934,-0.023619354,0.03930336,0.035350125,-0.14035274,-0.038651504,-0.010792811,-0.018777158,-2.3822362e-34,0.017700199,-0.061773177,0.062214375,0.07625121,0.00783673,0.066755086,0.018248638,0.04642702,0.008375354,-0.032938134,0.036661714,-0.029120075,-0.0785826,-0.0001452705,0.038167015,0.038483128,0.078566685,0.08707728,0.06026583,0.010974711,-0.0494896,0.079754815,-0.040696044,0.08221043,0.037163004,0.069051154,0.011347776,-0.0070649926,-0.022372194,0.0049602753,-0.029956833,0.038111854,-0.1127535,-0.096683495,-0.03217504,0.067513205,-0.06752791,-0.013290828,-0.046828188,-0.08491782,0.026856514,0.0003457307,0.08578869,0.07478225,0.0073372237,0.05306143,0.011463148,-0.021474954,-0.07974528,0.08581639,0.021583587,0.051040895,-0.059809078,0.0033927623,0.12358056,0.00641895,-0.025507983,-0.12879574,-0.02372936,-0.017877106,0.015656544,0.010193364,-0.058708534,0.03291244,0.0642227,0.02774114,0.0015115563,0.03484637,0.13687176,0.039137863,0.09271197,0.035298422,0.0050045922,0.056764178,-0.11707746,-0.06330235,0.02082266,-0.022162756,0.013932526,-0.087275155,-0.046656363,-0.023359172,0.054844975,-0.103755176,-0.10151794,-0.009791315,-0.023801094,0.0050425683,-0.022136925,0.039395988,0.034052953,-0.022457596,0.05681897,0.011748696,0.020308629,-1.9553543e-08,0.008889872,-0.04329135,0.077222034,-0.02433532,0.01386237,0.043639854,0.08603949,0.05710776,-0.0056826607,-0.062171936,0.046837043,0.05565799,0.1557133,0.00469789,0.094284214,-0.00078377547,-0.0043285596,0.011210133,-0.038103715,-0.023354834,-0.13702904,-0.013164923,-0.056217168,-0.0011529352,-0.0042522647,-0.011421189,-0.004500882,0.079819776,0.006706276,-0.033895034,0.049644496,-0.035491534,-0.000100529614,-0.052105997,-0.0060225865,0.04881974,0.055691306,-0.009366789,-0.017150199,0.013043079,-0.0795645,-0.03881476,-0.017342465,0.013495869,-0.020364413,-0.048819914,-0.019898592,-0.08006832,0.055176742,-0.028261067,0.10198462,0.038590953,-0.018078895,-0.03661937,-0.06798642,0.1012561,-0.012196349,-0.052008066,0.01805109,-0.07828209,0.050163403,-0.050658856,0.07532355,0.021917101 +2.6.1.55,"A pyridoxal-phosphate protein. Also acts on D,L-3-amino-isobutanoate, beta-alanine and 3-aminopropanesulfonate. Involved in the microbial utilization of beta-alanine.",384,1.0,-0.024710512,-0.13669172,-0.050744433,-0.1316442,0.07355268,0.09005968,0.04232296,-0.027988218,0.10241485,0.09040273,0.015985975,0.02439687,-0.08842246,0.10495979,-0.0030122197,0.022917185,-0.07247008,0.03301897,-0.0031916413,-0.043019094,0.09842891,0.10187486,0.006355963,-0.015401685,0.019918012,0.09817654,0.060128707,0.049050316,-0.007878067,-0.021812515,-0.011144079,-0.058702786,0.049853265,-0.08177212,0.053164408,0.09287748,-0.09926021,-0.031331625,0.056054313,0.047018763,0.042042,-0.018927388,0.0060807443,0.0037481287,-0.08763687,0.01323158,-0.00036336813,0.05804392,0.11020643,-0.07978517,-0.054920606,-0.05166944,-0.0055371714,-0.014126963,0.007845674,0.029941833,0.043581568,-0.009661347,-0.06338042,-0.056371808,-0.039335463,-0.00033103465,0.07366239,-0.004648333,0.009885814,0.012465738,-0.046842046,-0.06495612,-0.0009112069,-0.04921245,-0.09460693,-0.025500728,0.02630931,-0.0034625386,-0.0033935118,0.014559955,-0.015470209,-0.066295944,-0.043490954,-0.04556576,0.031980205,-0.021699516,0.03175295,0.029645436,0.023276603,-0.040084727,-0.006501364,-0.01687305,0.01095148,0.021579891,0.014487799,0.0031832142,0.06611519,0.012447951,-0.008687628,0.000920261,0.028101174,-0.0037903977,-0.02089782,-0.029528946,-0.05597497,0.04369749,-0.062437344,-0.054173067,-0.054562334,-0.0014752883,-0.06162011,0.06906541,-0.041309085,-0.022140892,-0.029158834,0.048960034,-0.011003573,0.05644945,-0.014471024,0.009035339,0.11791151,-0.053036228,-0.0576297,0.012439712,-0.009301316,-0.06485885,0.033184737,0.068629034,-0.009492443,0.027625157,-0.062048133,-2.9677022e-34,0.052949995,0.029763123,0.013622477,0.02038464,-0.0017231775,-0.028740805,-0.07626416,-0.014623764,0.050234787,-0.040172063,-0.029301533,-0.020046402,0.038138352,0.032644305,-0.017540425,0.07976884,-0.059780117,0.07398638,0.089867264,0.0070851888,0.024428006,0.060390268,0.0021504553,0.04341324,0.029736862,0.061036788,0.009726226,0.026161693,-0.0039527323,-0.016392704,0.01964531,-0.08565929,-0.14411955,-0.03518738,0.067036815,-0.02932965,-0.07545355,-0.03223954,-0.04021719,0.0248334,-0.010830701,-0.03817008,-0.030559853,0.008876374,0.003527506,-0.047468565,-0.014934894,0.07061921,0.012751398,0.066706,0.09357482,-0.0428204,0.091572315,-0.032287095,-0.09008199,-0.020733235,-0.06413985,-0.02903132,0.03196711,0.034291018,0.025699059,-0.027828025,0.013033115,0.028746018,0.023593156,-0.045343526,0.015594267,-0.06859355,0.046335377,0.06683493,-0.025104128,-0.031984,0.06209394,0.06651154,-0.057222214,-0.030689342,-0.10610393,-0.0022324487,0.023563854,0.02049873,-0.043015417,-0.054804806,-0.035851903,-0.050602432,-0.07382339,0.0068434607,0.052585367,-0.07346284,0.015596812,-0.058970306,0.0315621,-0.07019445,-0.07935373,0.061573703,0.025481107,-1.8620953e-33,0.06278156,-0.060975198,0.023089256,-0.042300466,-0.061480142,0.008698046,0.051199175,0.01882738,-0.0011832883,0.0054319496,0.011672971,0.017849984,-0.028382508,-0.06451106,0.013147159,-0.018947884,0.0008134474,-0.031872015,0.0017197962,0.038830932,0.029008467,-0.021422332,0.06832887,0.061727367,0.035054967,0.05652718,0.032757215,0.032120537,-0.0147683965,0.025700957,0.06456429,0.09394707,0.02229916,-0.09769909,-0.08929559,0.045971073,-0.04691478,-1.7387047e-05,-0.001190881,0.013398925,0.049694106,0.042531163,0.007925779,0.023949413,-0.015443554,0.07368589,-0.010917863,-0.046608567,-0.003820384,-0.08337697,0.01871997,0.0040909736,0.044481028,-0.016777983,0.051358555,0.05283373,-0.06646855,0.069946125,0.038821958,-0.0009912562,-0.012068269,-0.063874945,0.010716749,0.027499987,0.026230654,0.041261733,0.028735202,-0.02294255,0.07038677,0.055844665,0.05358342,0.027911104,0.09316031,0.079523765,-0.07747139,-0.037345916,-0.061885253,0.0299015,0.024764154,0.040544603,-0.019447898,-0.012810574,-0.056008715,-0.05158154,-0.026585285,-0.089663915,0.060356017,0.11208348,-0.06681007,0.014805426,-0.00051931705,0.016101059,-0.032523666,0.05576129,0.08044737,-3.6948872e-08,0.12322988,-0.005809094,0.040340144,-0.03936569,-0.041260257,-0.028934164,0.07189877,0.0827695,0.035391632,-0.01294575,-0.004610507,0.0062520104,0.023754768,0.0255,0.06603372,0.070497274,-0.07208903,-0.037434187,-0.029608155,-0.04581475,-0.06823048,0.017308384,-0.09300903,0.013866806,0.053485796,-0.046268623,0.029338434,0.04785468,-0.036111042,-0.0052028494,0.043570135,0.010449507,-0.004228902,-0.09252001,-0.040193796,0.05149562,-0.051538058,-0.04493001,0.029211495,-0.014192749,-0.061220497,-0.011920671,-0.08469156,-0.0088727735,-0.0136702,0.071719095,-0.11177893,0.08557743,-0.058009878,-0.05491791,0.0899836,-0.028504362,-0.07877489,-0.030399637,-0.15642431,0.07727479,-0.0022670156,-0.07288686,0.0111798905,-0.057166062,-0.010519884,-0.06630807,0.04579878,-0.07025589 +2.6.1.56,L-Glutamate and L-glutamine can also act as amino donors.,384,0.99999994,-0.04977794,-0.1252713,-0.024686081,-0.07429739,0.040946655,0.06785055,0.03897618,0.07261887,0.024336873,0.01617271,0.043873463,-0.016218957,-0.010130073,0.07377635,0.043552276,0.019690886,-0.030358067,-0.02838792,-0.09175548,-0.0015464133,0.038586516,0.089423135,-0.07932406,-0.07552207,0.038334243,0.036035232,0.022078868,-0.08960445,0.0481375,0.0030805382,-0.024327254,-0.0888514,-0.023574788,0.021633444,-0.008863348,0.03686131,-0.12744765,-0.041877173,0.04152312,0.0023433003,-0.0047704186,0.022924801,0.037448287,-0.09670428,-0.0615598,-0.05647172,0.094107404,-0.020085737,-0.011458374,0.025482832,0.054703787,-0.045059722,-0.02000559,0.031427573,-0.008546391,0.07259735,-0.10074,-0.0024424177,-0.039001998,0.04818795,-0.11048086,0.06903793,0.014023074,-0.060890093,0.08453229,-0.007485539,0.050718088,0.0017205412,0.04447617,-0.07306942,0.029107608,-0.059597608,0.08623246,0.035673093,0.07428552,-0.0034618005,0.00909524,0.0570541,0.0041322787,-0.020800266,0.021381639,-0.0013970681,0.019026916,0.055130582,-0.015761247,0.0075700157,-0.059914824,0.074712195,0.030519525,-0.015589792,0.021193165,-0.03208383,-0.0014636803,-0.020962123,-0.053042483,-0.01684624,0.0055574123,-0.005495568,-0.018427959,0.0054130405,-0.010235729,0.07537467,-0.011498084,-0.018123385,-0.022602346,0.02059168,0.014496864,-0.01758815,-0.031991124,-0.07463962,0.032911606,0.027211482,0.057876173,0.006365898,-0.06400641,-0.006689914,0.03739421,-0.04386882,-0.07938117,-0.01940411,0.008721868,-0.0036721185,0.051733706,0.033426285,-0.033806134,0.026168613,-0.075139746,-5.6619674e-34,0.009458379,-0.040663723,0.051692545,-0.007503297,0.03451459,0.020475354,-0.038697377,-0.018232366,0.11422588,-0.07878972,-0.1334707,-0.061073493,0.028067933,0.013683482,-0.06042783,0.059401978,-0.08058615,-0.057142094,0.040076207,-0.012430968,-0.010543848,0.030088767,0.02090288,0.032585837,0.007310239,0.021045936,0.04234851,0.017932069,0.038376898,-0.0074770846,-0.06221204,-0.044955377,-0.054588143,-0.022586675,0.011906833,0.042667184,0.012098124,-0.058602933,0.038737018,0.03669471,0.02188083,0.01972015,-0.05925474,0.042210624,0.056942828,0.030464364,-0.049303174,-0.0122342175,-0.12503783,0.04136251,0.06648796,-0.12521103,0.005996579,-0.03758154,-0.07323657,0.011999323,-0.032364305,-0.020349827,0.054085422,0.09452207,0.02338808,0.02898947,-0.002002506,0.03496666,0.02736085,0.02701054,0.0106350705,-0.10105095,-0.008724753,0.03758443,-0.05295585,-0.09593627,0.034873236,0.056973234,0.00023998134,-0.10063414,-0.02781038,0.039213832,0.06644253,0.010033232,0.065444104,-0.043754887,0.028555237,0.03698926,-0.046238337,-0.07166724,0.028591132,-0.15197463,0.0075986814,-0.060600005,-0.010213479,-0.029041952,-0.009530267,-0.053343974,-0.017409863,-1.507097e-33,0.061258532,-0.09179579,-0.022398572,-0.0020475541,0.008852257,0.0266662,0.03694286,-0.094516024,0.051238455,0.035829607,0.016978903,0.011126929,-0.0005423979,-0.014450384,0.03777775,-0.029350488,-0.062342208,0.01544644,-0.018481903,-0.019538634,0.008837987,0.04222721,0.058311448,-0.030775558,0.058579035,-0.003625872,-0.046395533,0.059602074,0.03978028,0.023535335,0.0026840405,0.004031508,-0.052797988,-0.12990256,0.0006832829,0.0365672,0.051962167,-0.022333844,-0.040165156,-0.06339829,0.014829012,0.08347716,0.12610647,0.06438046,-0.03393239,0.016494809,0.02031635,-0.07887101,-0.07109607,-0.049671456,0.047100715,-0.05523964,0.0070979446,-0.06830937,0.004252105,0.016714301,0.06297879,-0.04602828,0.040394362,0.0017188727,-0.07292208,-0.08687366,-0.017915843,0.038723238,-0.004740584,-0.029791333,0.10401403,0.017195774,0.0338499,0.021595545,0.096235305,-0.07244582,0.08589458,0.07388061,-0.046034824,-0.0040912773,-0.063302755,-0.002341151,0.05726936,-0.11361334,-0.0014653818,-0.04523933,0.024946397,0.009735729,0.08033898,-0.08818467,0.027449587,0.13645346,0.05779006,0.040351998,-0.047476728,-0.028439907,0.03687784,0.06275158,0.08599796,-2.4485592e-08,0.04963888,0.029993357,-0.043485347,0.044740845,-0.0070843347,0.03816975,-0.09905195,0.008399861,0.02209909,0.009882356,0.02382398,0.07546515,-0.09500099,0.03300043,-0.054749392,0.08777997,-0.066180505,0.035655472,-0.03915921,0.013370233,-0.0665583,0.044383995,-0.051457044,0.011231496,0.052305687,-0.023855569,-0.021656713,0.10314635,0.013276134,-0.044038437,0.0005280148,0.012008623,-0.008806579,-0.08806912,-0.03282413,-0.008769516,0.055167876,-0.02974723,0.022633754,-0.010517951,-0.04195355,0.043936428,-0.0276189,0.024949657,0.0020153017,0.024594318,0.02392084,0.013021882,-0.018878201,0.026650941,0.03275147,-0.050102923,0.015698496,-0.038476296,-0.11883406,-0.009035887,-0.07696206,0.0076529197,0.09574396,-0.08879268,-0.02691849,0.07984426,0.07774553,0.03450138 +2.6.1.57,"A pyridoxal-phosphate protein. L-Methionine can also act as donor, but more slowly; oxaloacetate can act as acceptor. Controlled proteolysis converts the enzyme into EC 2.6.1.1 aspartate transaminase.",384,0.99999994,-0.07197956,-0.07805622,-0.04694651,0.008331592,0.070819214,0.018569814,-0.06480457,0.10787719,0.015144573,-0.015613876,0.028982678,-0.029435495,-0.09670487,0.064271286,0.0016644227,0.04585494,-0.06163386,0.019239139,-0.0041744784,-0.004049259,0.08713486,-0.0017288588,0.007188828,-0.059607163,0.08896356,0.0061805444,-0.007990119,0.026414463,0.06678691,-0.065344915,-0.02990049,-0.03117915,-0.037815478,-0.036739267,0.050834466,0.13996942,-0.06889067,-0.043380484,-0.018876713,-0.01950225,0.10654058,-0.08044989,0.02856662,-0.066564925,0.012828432,-0.024889376,0.054818325,0.038692754,0.0248984,-0.06570207,-0.042460818,-0.019548794,-0.036643736,0.024461433,-0.062047098,0.09688413,0.00922849,0.038168583,-0.025126923,-0.04484948,-0.030541584,0.0014673928,0.02049231,-0.037972722,0.06030395,-0.08352835,0.03607487,-0.045808125,0.05411592,-0.021819493,-0.041890547,-0.036304194,0.09437471,0.039945785,0.03489016,0.004388144,-0.100181736,-0.009251838,-0.0010393073,0.0095175775,0.029487383,-0.06406878,-0.030248342,0.005272422,0.024994064,-0.0037241348,-0.028682917,0.005303615,-0.011591909,-0.0023136376,-0.051140007,0.0031718407,0.024482343,-0.023324354,-0.08610476,-0.00023329863,0.018720625,0.07783435,0.01470018,0.0010838656,-0.0011813841,0.11930959,-0.09036622,-0.061589334,-0.0772279,-0.03148231,0.008395959,0.04688669,0.029325802,-0.0046893707,0.025210021,-0.018800974,0.090588376,0.0119622,0.0008505497,0.092878886,-0.03229153,-0.06958044,-0.033958185,0.0289459,0.013909655,-0.029956453,0.084687814,0.04501392,0.009613674,0.050346155,-0.04743623,4.705804e-33,0.058096033,0.069654815,0.02933324,0.045760583,-0.07956623,-0.0017418447,-0.10158469,-0.007839832,-0.04356509,-0.11638594,-0.051361356,-0.017998163,0.097604044,0.04108882,-0.07333317,-0.08523559,-0.019641737,0.011298144,0.084530495,-0.0052959393,0.069666415,0.035006426,-0.026204882,0.09371757,0.024279963,-0.005059224,-0.03597902,0.02958382,0.0006510205,0.003088103,-0.043290254,-0.035124443,-0.0571246,0.019936102,-0.0060253856,0.004134366,-0.041016117,-0.089492686,0.015405869,-0.0040964694,0.006963804,-0.027672093,-0.003027911,0.030313848,0.06866646,-0.06878608,-0.04171154,0.008815644,-0.05578549,0.054898318,0.021096727,-0.09926419,0.07629386,-0.07839802,-0.092813626,-0.050231017,-0.026859285,-0.008732456,0.016446944,0.09576285,0.045103535,0.027947769,-0.03570796,0.044843238,-0.07817355,-0.011475172,0.0060735587,-0.052249387,-0.031559296,0.077535346,-0.06921176,0.021535642,0.029120822,0.07849418,0.0046222876,-0.042724155,-0.038932566,0.051496055,0.008687731,-0.007635769,0.0037671665,-0.02719768,-0.033443727,-0.017092692,0.010978914,-0.05101777,0.01764852,-0.114487864,0.03471471,0.014283355,0.03066405,-0.13243577,-0.063412406,0.012050316,0.03691416,-3.944838e-33,0.0926339,-0.053074718,0.06495513,-0.024063522,-6.652055e-05,0.013941794,0.09393351,-0.02300932,0.09356533,-0.03315242,0.101217106,-0.045341555,0.09311726,-0.07329755,0.02500117,-0.024579799,-0.027281672,0.017140416,0.06916872,0.027204162,0.020144569,0.068501554,-0.004052858,0.031699806,0.06268536,0.05858319,-0.03701156,0.02944647,0.054243967,0.018583706,-0.037628874,0.004909953,-0.046574153,-0.039324425,-0.07644144,0.09662132,-0.024590798,0.007882143,0.013266084,-0.03342387,0.038131457,0.049963146,0.018859386,0.04290725,0.013147316,0.014014698,-0.010362716,-0.03393843,-0.010548323,-0.06697206,0.050401375,0.014188154,0.0041619325,0.016103433,0.04009242,0.026676243,0.011043292,-0.008311585,-0.05364742,-0.011602894,-0.05477756,-0.0828416,0.04814303,0.052040253,0.034002967,0.005065713,0.06072486,0.06891054,-0.002831479,0.03646051,0.086689875,0.021936575,0.061390206,0.07161244,-0.009152959,-0.075953834,-0.08863832,0.06137071,0.020473622,-0.10353007,-0.07994829,-0.03299798,0.030427193,-0.0779129,0.072797075,-0.019384112,0.03332757,0.042096157,0.017777815,0.030750273,-0.07965589,-0.018568495,0.015570407,0.04185389,0.08335801,-4.0222123e-08,0.071010634,-0.044042658,0.039682217,-0.011828467,0.07116139,0.016185801,-0.018249497,-0.04124104,0.02568629,0.006634537,-0.07854049,0.06135777,0.06815903,-0.06409799,0.01761104,0.061553646,0.0019198114,0.06285256,-0.043162845,-0.023954472,-0.065182224,-0.030532705,-0.09358123,0.057579815,0.03835278,-0.0012589212,0.0011828209,0.044319082,-0.00801791,-0.062300548,0.011239914,-0.033170495,0.014124979,-0.00051014445,-0.04470294,0.028533278,0.0047284984,-0.04126408,-0.04924214,0.018372213,-0.0069893305,-0.01548664,-0.089603275,0.011655063,0.0039693257,0.04352548,-0.014700908,-0.029175585,-0.028945144,0.0020447066,0.09369946,-0.0708852,-0.016477078,-0.0811464,-0.10908393,0.058449704,0.016028218,0.037374932,0.06358771,-0.06515328,0.025054017,0.032270502,0.1759025,-0.066284396 +2.6.1.58,"L-Histidine and L-tyrosine can act instead of L-phenylalanine; in the reverse reaction, L-methionine, L-serine and L-glutamine can replace L-alanine.",384,1.0,0.0034544328,-0.09770579,-0.010337622,-0.060120367,0.06883815,0.0675724,-0.04287252,0.059427485,0.02087951,0.049833328,0.016875513,0.026850533,-0.039628766,0.05080386,0.03934934,0.005215789,-0.04851505,0.012572758,-0.066230744,-0.00993571,-0.008030228,0.06367492,-0.070114955,-0.0012705292,0.010989021,0.0021849251,-0.03571866,0.022617392,-0.02380837,-0.047596574,0.0038190228,-0.045645803,0.052205894,-0.054800875,-0.039475527,0.02329539,-0.12198237,-0.002917804,0.07294001,0.02286754,-0.014104735,-0.020297002,-0.02751362,-0.06411545,-0.0063606272,-0.002476401,-0.09252952,-0.009970012,0.03310661,0.101344496,0.008294198,-0.016683968,-0.020327799,0.019538894,-0.029234177,0.030953545,-0.11828287,0.06448491,-0.010633161,0.011869075,-0.02681633,0.04488931,-0.02600979,-0.029150257,0.02798034,-0.037361365,0.0151445335,-0.08766885,0.10926464,0.018252108,0.025844196,-0.05189978,0.048860144,-0.027045421,0.01133275,-0.050550796,-0.04146049,0.05531476,0.011406824,0.033169195,0.020815952,-0.03982557,-0.026326356,0.031799898,0.014091981,-0.031081837,-0.0943028,-0.02127932,0.110860586,-0.05785495,0.026976403,-0.06331565,0.010478072,-0.02596646,-0.014094485,-0.04530974,0.007412617,0.015681995,-0.0092153475,0.02153729,-0.02122305,0.03653187,-0.1285999,-0.03432973,-0.054046698,0.01549924,0.021204712,0.021518186,-0.091766804,-0.06835309,0.07115098,-0.020826818,0.11361696,0.008476986,-0.023085715,0.038599793,0.047016297,-0.017544644,-0.050022025,-0.02014844,0.025155257,-0.040801845,0.08735665,0.038727418,0.008645997,0.06667942,-0.0051783053,1.4355732e-33,0.054269392,0.03404601,0.020141585,-0.0213378,0.048166044,0.0008680779,-0.06435514,0.03415922,0.10748656,-0.12849393,-0.054419093,0.0024088298,0.022982,-0.019830385,-0.09764838,0.048412394,0.015040092,-0.021445354,0.0670985,-0.019006401,0.009294597,0.08870292,0.008821897,0.030865591,-0.040520642,0.0092687,0.043972977,-0.013959044,0.014962466,-0.004750164,-0.05175518,-0.0100576235,-0.017655391,0.08077168,-0.058062464,0.07436763,-0.11550859,-0.048441622,0.037656877,0.0047486303,-0.0070974245,0.07039277,-0.06272017,0.02358848,0.013886646,0.011611985,-0.010923741,0.0260139,-0.07171932,-0.055071592,0.07234782,-0.03943404,-0.034771197,-0.042072587,-0.06225736,0.035178717,0.0064400868,-0.009170675,0.03975102,0.15706104,0.0912298,-0.008877502,0.054126367,0.06351888,0.02442702,-0.0063742297,0.0038708977,-0.048747685,-0.02706591,0.008915661,-0.028803969,-0.05444635,0.06233825,0.10660761,0.017416723,-0.06935386,-0.042051956,0.039274327,0.011464617,-0.062848955,0.035524435,-0.02095295,-0.020265004,0.065428615,-0.027903408,-0.06664671,0.014930196,-0.13607559,0.0208059,0.01557779,-0.0200562,-0.05335678,0.032465715,0.019069651,0.063352026,-2.937026e-33,-0.012580386,-0.091842264,-0.009199612,0.016164199,-0.06375464,0.049050484,0.05988569,-0.08563318,0.06793571,0.025473796,0.05031853,-0.06500524,-0.06457488,-0.039695513,-0.059513256,-0.004362886,0.065464795,0.0396783,-0.044175014,-0.013326242,0.003446176,0.03122195,0.019555196,0.012992199,0.11629959,-0.0022235373,0.0062505566,0.078585714,0.059774633,0.037257813,0.0012006711,-0.015968507,0.02861553,-0.065004095,0.016184816,0.107812256,-0.028635295,-0.008124235,-0.0039390535,-0.034268294,0.037851244,-0.033591207,0.10718259,0.034478694,0.02330199,0.013158317,-0.10639431,-0.08677767,-0.05358,-0.11993446,0.025000919,-0.044074234,-0.021676298,-0.06897499,0.015435305,0.068617515,0.03322177,-0.046077468,-0.0123037165,0.028944941,-0.021782242,-0.07694792,-0.005972864,0.0128883,0.03200848,0.039783042,-0.00023973476,0.0018216899,0.10601742,-0.045476615,0.06695726,-0.039414883,0.114075236,0.08685932,-0.0022433507,-0.08823638,-0.037464105,-0.040235393,0.029847885,-0.11881247,-0.045257688,-0.07473785,0.028595343,0.007915991,-0.029583557,0.045572624,-0.014670993,0.10022746,-0.012024971,0.05650907,0.0057624876,0.00963897,0.001030666,0.009425967,0.12528561,-3.441289e-08,0.09082978,-0.10697611,0.028485756,0.04850727,-0.06964954,0.030293722,-0.04430539,0.024249064,-0.033435762,-0.040422454,-0.041165777,0.10448338,0.012391415,-0.02197603,-0.08388769,0.075875,-0.061365467,0.007059752,-0.028739048,0.036640633,-0.092328824,0.018792091,-0.039769907,-0.029231692,0.023065051,-0.026275937,-0.043839797,0.09912876,0.036432005,-0.054674342,0.0557441,-0.051364694,0.0053123794,-0.0110434275,-0.029676687,-0.028563092,0.01129592,-0.046787728,0.026553605,0.00065887213,-0.04229274,0.063381374,-0.09206063,0.06295347,0.008476187,-0.07197698,0.06501276,-0.005937902,-0.038235176,0.021562088,0.079096876,0.016285365,0.04938555,-0.01735232,0.00027451865,-0.012959884,-0.04902229,-0.0024093748,0.03103445,0.009794511,-0.007314936,-0.0019100417,0.10030823,0.00071782747 +2.6.1.59,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.60,"Phenylalanine, kynurenine, tyrosine and histidine can act as amino donors; glyoxylate, pyruvate and hydroxypyruvate can act as amino acceptors.",384,1.0,-0.028077934,-0.08652423,-0.067656025,-0.08300495,0.027959015,0.0916772,0.039892077,-0.006678812,-0.005609825,0.06390741,0.06115743,-0.016927527,-0.060241178,0.12959586,0.04647177,0.03154482,-0.043931235,-0.004213783,0.003180189,-0.02767316,-0.0067757494,0.053835537,-0.008603261,-0.02144362,0.011318796,-0.006068642,0.04313649,-0.05000561,0.035601843,0.025742393,-0.062822945,-0.123485856,-0.0042205737,0.016339216,0.029223178,0.09004501,-0.11281944,0.008080636,-0.05828631,0.0155816395,0.028160907,-0.008716664,0.025631238,-0.028590294,-0.036813125,-0.0437521,0.07379428,-0.055231407,0.0034795552,0.04316344,0.020379918,-0.012022039,-0.014404512,0.011788716,0.0064629917,0.062713124,-0.104249716,0.0030758982,-0.0051953564,-0.011881133,-0.073534,0.03589573,0.040944476,-0.08816859,0.030937955,-0.009018247,-0.0107964855,0.010911845,0.019544693,-0.06231973,0.035077948,-0.07974928,0.094272725,0.0059027663,0.020087767,-0.0036668999,-0.03701323,0.0187724,0.012103944,-0.037270352,-0.07075249,-0.03759485,0.008697344,0.045735694,0.021231424,0.0492317,-0.06733553,0.055927943,0.02476853,0.017430242,0.01787764,-0.010286762,0.042193137,-0.06176815,0.0040392494,-0.051136382,0.063883305,-0.026482662,0.011765857,0.00904063,0.0074583907,0.09952987,-0.08230147,-0.045931872,-0.088747844,0.021325182,-0.017352149,-0.012991695,-0.0049671256,-0.0049008275,-0.022774482,-0.0098571,0.0830831,-0.01673467,0.041159477,0.03040128,0.013724864,-0.06372941,-0.03127728,-0.026480211,-7.3418065e-05,0.0036395122,0.119968034,0.08332039,-0.022084622,0.0489645,-0.03821036,6.0095595e-33,0.033965338,-0.0011901865,0.02851626,0.046922617,0.0018276627,0.006290203,-0.013937691,-0.010945083,0.072600275,-0.13279957,-0.14840266,-0.059743926,0.07494611,0.020642519,-0.09162341,0.0027435322,-0.0491305,-0.023472514,0.07286794,-0.014928041,0.018647296,0.08279229,0.0625292,0.04106338,-0.00093692326,-0.027569693,-0.021328643,0.052065693,0.04995772,-0.027502414,-0.01623063,-0.09054309,-0.046094462,-0.027444802,-0.06344043,0.01656494,-0.04495868,-0.019265648,-0.0072489236,0.03721347,-0.052517477,-3.1785203e-05,-0.03883038,0.05158538,0.042722948,0.049242005,0.028772186,-0.008807925,-0.13045292,-0.027411373,0.06355029,-0.10656807,-0.024984514,-0.06183895,-0.060696743,0.040140204,0.024124172,-0.039443836,0.041305467,0.09345507,0.05782087,0.021723278,0.045647115,0.0031856068,-0.019541837,-0.012723058,0.011589215,-0.089572154,-0.04137637,0.026068715,-0.056496583,-0.021026678,0.054219663,0.0579186,0.03194952,-0.08566276,-0.06377986,-0.00034619548,-0.015096803,-0.030272186,0.03646977,-0.069792815,0.010694889,0.05715527,-0.053559985,-0.033084296,0.012221485,-0.13838492,0.06866206,0.010604631,-0.0018273807,-0.11130331,0.0047386657,-0.064665176,-0.00069878856,-5.9739383e-33,0.07397421,-0.09840382,-0.015427772,-0.041680515,0.0017256457,0.060103975,0.040296827,-0.084248625,0.08818281,-0.043905273,0.061920643,-0.041797902,0.043121956,-0.019227495,-0.0067481766,0.0160026,-0.0056965607,0.049594566,0.0017924866,-0.007579453,-0.03391508,0.0021388067,-0.03269032,-0.040554337,0.052710004,0.069929615,-0.06803288,0.09138653,0.09483599,0.038524188,-0.035398915,0.013165962,-0.071099296,-0.08302001,0.050540395,0.068816945,-0.072479255,-0.036315225,-0.015780592,-0.05712951,0.03404909,0.038822837,0.0698077,0.097336546,-0.036455862,0.05075465,-0.017429069,-0.03158748,-0.056951653,-0.05765795,0.0066224593,-0.017362788,-0.005305105,-0.031512145,0.028757013,0.08089616,0.03431179,-0.044339392,0.045935325,0.008223029,-0.052853506,-0.12994146,0.051870726,0.02881584,-0.017376466,-0.03398314,0.021468865,0.039766908,0.07673265,0.032948837,0.03445189,-0.06075236,0.12893891,0.10275642,0.029092664,-0.026125088,-0.023656007,0.03345806,0.070145056,-0.113715485,-0.04340595,0.008797827,0.011308021,-0.012412834,0.08276342,-0.008843709,0.07594283,0.08868318,0.04060412,0.004016177,0.016663078,-0.021997005,0.015500357,0.046650372,0.09770087,-3.6202792e-08,0.05558652,-0.042824436,-0.00363701,-0.013279342,-0.089037515,-0.0001368866,-0.02709552,0.003698377,-0.017867172,-0.033539824,0.040552303,0.06686784,-0.008651716,-0.01604244,-0.058807276,0.06885872,-0.09062325,0.08046416,-0.024405366,-0.06151793,-0.10545654,0.03653679,-0.08382224,-0.0042181155,-0.010171435,0.019177016,-0.040124863,0.09003355,0.015862597,-0.06522469,0.021887867,-0.022295883,-0.020021947,-0.059871264,0.066065006,0.043990046,0.024448933,-0.01204134,0.045987852,-0.03031066,-0.038223855,-0.035966955,-0.058401637,0.0065689827,0.03868079,0.043409508,0.018273376,0.02075949,-0.02289661,0.01679167,0.031270362,-0.01798454,0.031818047,-0.04966096,-0.07117999,0.01690377,-0.040942106,-0.033648554,0.03317832,-0.06152251,-0.043035507,0.06293513,0.09872071,0.0088203605 +2.6.1.62,A pyridoxal 5'-phosphate enzyme. S-adenosylhomocysteine can also act as donor.,384,1.0,-0.037334308,-0.06727195,-0.037740085,-0.069146045,0.053460255,0.033842765,-0.03447484,-0.013676166,0.047511313,0.07728945,0.013123266,0.04949235,-0.080982514,0.101919614,-0.013282365,0.06848841,-0.065886326,0.026780494,-0.0127424775,-0.051705994,0.029307505,-0.030734664,-0.0016625386,0.026027903,0.04960853,0.01032282,0.023278749,0.021316584,-0.07376419,-0.034724258,-0.07696635,-0.054957762,-0.042371314,-0.02882458,0.045345187,0.12930726,-0.08341407,0.03509931,-0.03777252,0.008400803,0.054962847,-0.1013951,-0.028875645,0.042358484,-0.11247971,-0.010315046,0.031998046,0.0568372,0.06184475,0.0036677793,-0.011696705,-0.04250726,-0.10799124,-0.07662894,0.0005719671,0.10009481,0.0058478597,-0.014212085,-0.034755114,-0.037274472,0.012420586,-0.028762285,0.046577495,0.012899923,0.082319625,-0.046969995,0.064223774,-0.04793761,-0.0120508745,-0.034697182,0.013213378,-0.043238312,0.10540307,0.01753916,0.009996716,0.013551279,-0.073010705,-0.0025035269,0.03211237,0.028122902,0.000685989,-0.008382244,0.03243115,0.007012072,0.06668347,0.033378933,-0.0023472956,0.028086536,-0.04381504,-0.012125304,-0.040524416,-0.018666899,0.03722605,-0.03177577,-0.054759853,-0.024635108,0.006271122,-0.010365944,-0.034862313,-0.040851787,0.015978118,0.048754886,-0.029130066,-0.048821375,-0.0009344267,0.008513023,-0.087621,-0.0009254283,-0.025753345,-0.0009456054,-0.061809927,0.0862366,0.018236518,0.022228368,0.03456611,0.049577102,-0.060972735,-0.04170463,-0.08310923,0.0432392,-0.029323742,-0.018783553,0.010585342,0.1078239,-0.065049544,-0.013280969,-0.0382713,9.2867185e-34,0.024174249,0.089845516,0.06186708,0.058654226,-0.05273519,-0.012747317,-0.026257671,0.040643074,-0.07991041,-0.029468913,-0.07002992,-0.07914022,0.12470654,-0.021186043,-0.07712036,-0.040037144,-0.08495308,0.034189887,0.056117225,-0.013852109,0.03331523,0.07041911,-0.019649591,0.0845679,0.011064008,0.039050777,-0.039542228,0.032508697,0.11441375,0.0058311834,-0.022262251,-0.05924109,-0.09064816,-0.067671955,-0.0045658466,-0.031227184,-0.004229912,-0.043301318,-0.010482569,0.03197167,-0.04086384,-0.06345661,0.0077066165,-0.006214103,0.018104121,-0.07186747,-0.027977385,-0.0031995652,-0.092502855,0.037645187,0.01343871,-0.12460396,0.084532805,-0.006394534,-0.10344235,-0.05352121,-0.0127746435,-0.03467919,-0.015270033,0.019075453,0.055359684,0.014082983,-0.029500643,-0.055240594,-0.07892186,-0.012654914,0.023278538,-0.08515503,-0.0077336445,0.06646412,0.054008834,0.068629414,0.047692087,0.07460084,0.0048519843,-0.009158117,-0.0071258177,0.028374802,0.022155242,0.059336398,-0.019823503,-0.055080526,0.006182021,-0.02204422,0.0026373828,-0.06331584,-0.017646896,-0.09320068,-0.035289805,-0.002097659,0.056162663,-0.112056896,-0.020735538,-0.026916975,0.046396237,-2.5429603e-33,0.1258068,-0.08510791,0.066613734,-0.046133794,0.0010556536,0.026529292,0.07171897,-0.025006527,0.050054614,0.022268172,0.026809584,0.00722325,0.05913253,-0.0542983,-0.006208735,-0.0116471695,-0.06333447,-0.005749025,0.06809683,0.017300515,-0.0074784565,0.05027566,0.035012204,0.03299951,0.054085393,0.032423463,-0.058773577,0.017883189,0.051292412,0.013784011,-0.019186268,-0.012988466,-0.06541516,-0.013963635,-0.015831826,0.081160665,-0.04950311,0.04520383,-0.03881918,0.021211807,-0.0051099635,0.0814973,0.07274226,0.0712577,-0.033464804,0.07028082,-0.013002819,0.080874056,0.07150895,-0.06455126,0.010991078,0.039576374,-0.04179365,0.037046604,0.05362826,0.09498309,0.04371318,-0.0019988627,-0.041775666,-0.05940544,-0.065154016,-0.069256715,0.02653793,0.024135232,0.00050277147,0.059654288,0.0128983585,0.029026369,-0.011412387,0.009812993,0.051399715,0.026809197,0.012665347,0.06673267,-0.033032253,-0.06734448,-0.023537546,0.051801052,0.028293923,-0.03002341,-0.0001078353,-0.016356165,0.03038911,-0.07334702,0.087175086,-0.045858324,0.11711986,0.07526925,0.011225035,-0.0065475916,-0.021730296,0.033492006,-0.0067615476,0.02217607,0.05838054,-2.7469529e-08,0.076035894,-0.03782475,0.0181347,-0.11491946,0.06190181,0.015256051,-0.0020558825,0.010160817,0.09199575,-0.024416631,-0.045114275,0.040333137,0.01716851,0.045747306,0.03626397,0.005985431,-0.0160309,-0.01967959,0.014150642,-0.11760793,-0.123232685,-0.009269898,-0.10605643,0.023500035,0.027081272,0.07853163,0.028023146,0.013499305,-0.036126282,0.00079668924,0.058404755,-0.047586616,-0.089559525,-0.03341696,-0.0046666632,0.08647072,0.00060803565,0.008798237,-0.024260536,0.026765384,-0.044135235,-0.037231,-0.04465412,0.030029405,0.018739635,0.03465682,-0.011888075,-0.01967111,-0.022196991,0.03651953,0.057299234,-0.04530039,-0.0943937,-0.06972918,-0.10421867,0.038232878,0.03259423,-0.056035407,0.043390024,-0.06557412,0.004327505,0.020510878,0.16005462,-0.058665022 +2.6.1.63,"This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7, kynurenine---oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions.",384,1.0,-0.014233245,-0.061000284,-0.033895027,-0.0487793,-0.031627465,0.017009938,-0.0022326931,0.06564496,-0.005933472,0.0658156,0.07188331,-0.07239649,-0.022765107,0.05383765,-0.048893597,0.11490706,-0.08346345,0.003679964,0.0082882,-0.012945322,0.04558199,0.04539608,-0.035796873,-0.059822205,0.05219459,0.03979829,0.044547193,-0.07732109,0.046049368,-0.012550768,-0.04927881,-0.09369031,-0.0029543766,-0.0057282182,0.06563383,0.07308047,-0.112909004,-0.011105074,-0.019632513,-0.010621927,0.05455847,-0.00307134,0.0012893734,-0.062892295,0.03552428,-0.03681357,-0.027849577,-0.055286337,0.03968592,0.036270726,0.020608472,-0.039576847,-0.054053728,0.061835412,0.038353477,-0.02058478,-0.060682077,0.0005531223,-0.031118281,0.010451499,0.008967164,0.05919935,0.010740288,-0.0507888,0.05372399,-0.046006903,-0.038721714,0.0037752865,0.0065554753,-0.09172586,-0.042490516,-0.07219109,0.019913407,0.024747146,-0.05791691,-0.03989654,-0.0062847394,0.059781127,-0.0064384053,-0.0664361,0.019040668,0.028072936,0.031865,0.05991813,0.015606546,0.021857772,-0.053350337,0.02765191,0.014588823,0.045347773,0.015591167,0.048597295,0.016443899,-0.054723002,0.0035970071,0.005296059,0.031159723,0.05706305,0.06732765,0.00969456,0.0112937335,0.10020308,-0.07510724,-0.10051266,-0.12204501,-0.026727702,-0.034938626,0.04149312,0.05203553,0.0022383865,-0.023770494,-0.01766376,0.011438959,0.010281811,0.011593756,0.087899916,0.021630775,-0.036443792,-0.002120662,0.008427636,0.021301351,0.0067972597,0.13603044,0.09164862,-0.016597062,0.029338868,-0.036297344,-3.6554458e-34,0.06338217,0.014713448,0.0095577575,0.041700717,-0.0047178473,-0.011604055,-0.06548076,0.025363626,-0.029996485,-0.064687975,-0.14891554,-0.058759186,0.049928352,-0.047887187,0.008386027,-0.009296593,-0.02694923,-0.011705153,0.0974008,0.011056719,0.015786262,0.053458877,-0.015672727,0.050955616,-0.033124115,0.030780079,0.010498558,-0.011985075,-0.00026787515,-0.0046330746,-0.022152293,-0.0903915,-0.07233778,-0.07474788,-0.058819212,-0.008992656,-0.01960436,-0.058185965,-0.026676048,0.074311614,-0.014046953,-0.035218865,0.009203642,-0.017991416,0.10860826,0.0029170231,0.0060629444,-0.017197415,-0.026159085,0.03152208,0.017042736,-0.02424073,0.05837379,-0.0110494485,-0.07100874,0.038926303,-0.01271924,-0.053131457,0.046657275,0.07435198,0.023050109,0.045588933,-0.06379779,0.0067969086,-0.0437066,-0.034927692,0.0012529563,-0.08281677,-0.051195372,0.038512554,-0.08001526,-0.067297794,0.06306469,-0.0006292324,0.03577611,-0.11375594,-0.040869266,0.08715196,-0.026513333,-0.055332847,0.030169778,0.06270608,0.0077874726,-0.040369466,0.040539265,-0.01651262,0.016053531,-0.082367666,-0.014439373,0.082741775,0.04412856,-0.06437713,-0.13182685,-0.014959575,0.034534305,-1.1032256e-33,0.057956807,-0.10468522,-0.04865925,-0.02463819,-0.011043519,0.02035208,0.021661524,0.059386995,0.04737831,0.005882905,0.12953983,-0.009020576,0.056204937,-0.04473253,0.021158913,0.023100995,0.014432492,0.095085315,0.0107441405,-0.051810794,0.04694558,0.07191485,-0.03917828,-0.06278685,0.039273232,0.041205876,-0.031150041,0.09184015,0.101541616,0.034253106,-0.06849354,-0.017210921,-0.013716678,0.005664031,-0.027692711,0.02655034,-0.06314875,-0.014102822,-0.026366659,0.04296439,-0.0060622124,0.09471763,0.042158473,0.0734853,-0.012217527,0.059186686,-0.048940107,-0.021812975,-0.002679822,-0.07722412,0.09055279,-0.030689996,-0.0014167201,0.026568249,0.0001263517,0.052518956,-0.0071423845,0.043725327,-0.046609916,0.031692967,-0.012037811,-0.14365727,0.093346044,-0.028943669,0.049909785,0.0452572,0.024112187,0.059327263,0.012917896,-0.027197743,0.01023652,-0.068226226,0.042101473,0.043518115,0.0018079957,-0.03739978,-0.051903825,0.034743104,0.02984781,-0.0838891,-0.043987498,-0.009357703,0.062807806,-0.076230824,0.057110455,-0.055804737,0.033334855,0.16053045,0.02742617,-0.012263638,0.000927372,-0.021941883,-0.04920587,0.054745704,0.076739505,-4.2992035e-08,-0.058244284,-0.09235797,0.011139865,-0.032601405,0.010056152,0.027063364,-0.0042291363,-0.0057830364,0.010235183,-0.09085848,0.04673424,0.06815852,-0.07446148,0.026956202,0.021763517,0.07821547,-0.029108617,0.07994478,-0.0062536076,0.021111162,-0.0917952,0.018003657,-0.09233067,-0.040878985,-0.04302569,-0.018512199,-0.0059839184,0.059831023,-0.0057570296,-0.055746008,-0.009686694,0.045633413,0.016343892,-0.045620255,-0.09883998,0.025165807,0.005971679,-0.055173706,0.0029435316,-0.019579241,-0.025593285,-0.048947,-0.04326177,0.020196564,0.022977334,0.009060736,0.026227027,0.029158315,-0.028901082,-0.029619055,0.039313972,-0.04293955,0.0043640793,-0.111736886,-0.06264802,0.020459605,0.00642578,-0.08125036,0.025456792,-0.063771196,0.02447665,0.03880015,0.19164613,0.043946035 +2.6.1.64,"A pyridoxal-phosphate protein. L-Methionine, L-histidine and L-tyrosine can act as donors. The enzyme has little activity on pyruvate and glyoxylate (cf. EC 2.6.1.15 glutamine---pyruvate transaminase).",384,0.99999994,-0.06912344,-0.04487026,-0.09107021,-0.04677549,0.07895937,0.06826596,-0.020729223,0.07562119,-0.0011776665,0.027633375,-0.00473895,-0.022327792,-0.10674666,0.118532345,0.008880956,0.023238922,-0.045382407,-0.028566375,0.027829017,-0.0320383,0.08355393,0.029614253,0.03851214,-0.06704943,0.061827388,0.008269691,0.013974027,-0.0018623101,0.053019945,0.00058168353,-0.10019307,-0.07396183,0.011796387,-0.055526637,0.08176137,0.16438091,-0.099526115,-0.018515747,0.00015742636,-0.0017096754,0.0882557,-0.029117564,0.0015396102,0.006271279,-0.05524778,-0.0061543663,0.07156135,0.020615827,-0.008483145,0.011623886,-0.015455292,-0.008392048,-0.017082233,-0.0011470546,-0.008276258,0.076074466,-0.013421242,0.02752332,-0.050406247,-0.036497783,-0.044364825,0.013802982,0.027497694,-0.063826546,0.04651398,-0.05022035,0.07873428,-0.012900468,0.05337764,-0.07011504,0.003343083,-0.039401647,0.11721595,0.013790325,-0.022382258,0.041011885,-0.045386642,0.020391146,-0.020311534,0.014946453,-0.019873157,-0.06561525,-0.012051288,0.05376336,-0.0017372294,0.010201048,-0.038419265,0.032469045,-0.0047620023,0.0054595824,-0.030919088,-0.009846681,-0.0035362644,-0.0361191,-0.077127926,-0.01399769,0.028177759,-0.009468934,-0.01739364,-0.022479547,0.0008219512,0.102296636,-0.055346437,-0.02366097,-0.08247949,0.025144713,-0.030333316,0.016855549,0.013332015,-0.022686258,0.0056688846,0.07407816,0.10130373,0.01054408,0.009808118,0.042068396,-0.007840989,-0.075890265,-0.07472038,0.057722583,0.05168062,-0.036222056,0.09272618,0.048149217,-0.028948318,0.03622526,-0.044906523,3.22336e-33,0.07288418,0.06938289,0.022764644,0.04326631,-0.025867144,0.022817772,-0.09426162,0.0038872515,-0.026940316,-0.057427328,-0.091906525,-0.047603495,0.112371534,0.009370855,-0.12125625,-0.0025653706,-0.026688095,-0.038616188,0.10093274,-0.033677258,0.055661447,0.07692856,0.045439593,0.083370134,0.031498507,0.040857382,-0.01882337,0.03206226,0.007811123,-0.01745383,-0.009655484,-0.10232616,-0.05142529,-0.017685087,0.00980333,0.01975576,-0.08102487,-0.0746068,-0.008390274,0.022966294,-0.013283365,-0.02626577,0.012127119,-0.0017670413,0.022555385,-0.06604549,-0.011446574,-0.008941918,-0.07644828,0.04299409,0.07353137,-0.112058446,0.025824197,-0.07178463,-0.1119513,0.0009787915,-0.0031606196,-0.03730832,0.049721,0.08294819,0.0818679,0.019478848,-0.013869919,-0.0028208522,-0.028735595,-0.015679682,-0.011114579,-0.09159206,-0.046176575,0.09296907,-0.038468316,-0.04326702,0.043125603,0.05231815,0.002406251,-0.039404597,-0.03290318,0.056791093,-0.0029919953,-0.02275831,0.033529803,-0.089216396,0.015096227,-0.015450055,-0.046770953,-0.050616927,-0.032206878,-0.12272613,0.037948515,-0.016284943,-0.027741443,-0.09490685,0.011117667,-0.04705896,0.00037052092,-3.5320093e-33,0.086481616,-0.08194614,0.044759624,-0.06651116,-0.0024231428,0.04257715,0.061783224,-0.07464324,0.044922065,-0.0049277535,0.062058263,-0.05022142,0.042430475,-0.06152533,0.02405292,0.027922243,-0.0011110175,0.015585138,0.02417493,-0.012296572,-0.014077465,0.07519489,0.0014433351,-0.0017921894,0.062772036,0.05091711,-0.018773727,0.033561375,0.039498564,0.0054040845,0.011390815,-0.0005910499,-0.06197527,-0.08093095,0.0023774146,0.081879325,-0.06403142,-0.015653055,0.0067704767,-0.0136997355,0.069890104,0.06590989,0.09059812,0.06301735,-0.012450071,0.017191326,-0.060932823,-0.07070111,-0.03437419,-0.03140767,0.017809324,0.00692163,-0.0253975,-0.034285914,0.07139069,0.06335529,0.0058531812,-0.01689894,0.014323778,-0.0072034127,-0.021075921,-0.097131915,0.00081164186,0.08633321,0.03944023,0.013952313,0.044754226,0.025046429,0.035616584,0.089609094,0.08217768,0.0050520473,0.055895917,0.08012421,-0.050397445,-0.009284045,-0.08966191,0.048101354,0.06944886,-0.12216209,-0.0062170303,-0.032350156,0.025838492,-0.058112476,0.060634725,-0.051334724,0.027953617,0.09543295,0.056944076,0.003988128,-0.03681692,-0.019347299,-0.007654309,0.017577518,0.11955942,-4.72997e-08,0.0780712,-0.017961087,-0.010234132,0.0039579445,-0.03639228,-0.017889995,0.0075813266,-0.0032090629,0.039140865,0.020604813,0.004022166,0.061045114,0.018960569,-0.06327263,-0.016781284,0.06189777,-0.07279231,0.05570273,-0.045082785,-0.018917872,-0.09107787,0.01652107,-0.11635576,0.030979449,0.029051652,-0.019043954,0.010531853,0.058706656,0.02873328,-0.056058668,0.03876281,-0.010716368,0.0023960944,-0.05905706,-0.020625375,0.047260933,0.004486221,-0.016788235,-0.0046779052,0.009917235,-0.040027924,-0.02530324,-0.057921413,0.027942153,-0.021431515,0.054532126,-0.009935483,-0.014679653,-0.025383996,0.033525176,0.080141366,-0.040232,-0.04499975,-0.06021711,-0.11947847,0.0427325,-0.012354776,0.027919821,0.050447237,-0.107253216,-0.011717314,0.020968081,0.13137163,-0.0767854 +2.6.1.65,A pyridoxal-phosphate protein.,384,0.99999994,-0.027926307,-0.082669966,-0.06864404,-0.0736116,0.027612139,0.00069278304,0.043136388,-0.0022198383,0.07759752,0.061581366,0.050052542,0.024383662,-0.07972978,0.075630225,-0.018062996,0.011146767,-0.058814332,0.026981099,0.028646505,-0.060484987,0.08062581,0.046058796,0.013964545,-0.0034948976,-0.022635197,0.09317548,0.03897881,0.08481283,-0.022757838,-0.06512055,-0.033645604,-0.002438178,-0.04265655,-0.081326276,0.049699727,0.09206192,-0.10426549,0.024624566,0.01641356,-0.038264256,0.09138554,-0.06995117,-0.019178458,0.015225969,-0.079754055,-0.009005391,0.060174454,0.06121611,0.1076781,-0.0044863066,-0.08720911,-0.014019634,-0.013987518,-0.049955927,0.010103739,0.04439458,0.025756652,0.03877331,-0.030249724,-0.031439897,-0.018875996,-0.014899653,0.033183742,0.03005634,0.045147188,-0.03863779,0.011696549,-0.046883464,-0.028674698,-0.0040879943,-0.0399809,-0.0017529497,0.12130531,0.0010538863,-0.034636367,0.09728037,-0.028074443,-0.023704544,-0.04040873,0.055432733,0.03498061,0.00886843,0.038521856,0.08173242,0.056242175,0.02956211,0.015032759,-0.008670652,-0.0671204,-0.03498028,0.0024070852,0.025017837,0.033844747,0.03431295,-0.017365431,0.020294111,0.0095834825,-0.017277373,-0.049156386,-0.05037137,-0.0135520855,0.006560372,0.029906176,-0.04925029,-0.040218767,-0.005961301,-0.070319004,0.04136831,-0.008511003,-0.0040058997,-0.05803713,0.0810462,-0.012979407,0.006107804,0.023426063,0.022639925,0.016739301,-0.004660274,-0.05652102,0.057704583,0.0031750596,-0.032194667,-0.030190036,0.08859248,-0.054773755,-0.0542106,-0.07686096,-2.4678308e-33,0.06313784,0.074121,0.050783433,0.040298108,-0.011358971,-0.014224093,-0.06284932,-0.054584622,-0.06972202,-0.006010194,-0.005837788,-0.041249312,0.07401363,0.007710753,-0.07779482,-0.03148981,-0.09894455,0.03780528,0.09449977,-0.054316152,0.036347546,0.122786574,0.015729465,0.06573166,-0.023447253,0.10535222,-0.04718892,-0.017551308,-0.020911029,-0.010473525,0.017130276,-0.08890346,-0.10486213,-0.037216794,0.029635139,-0.1032107,-0.053137314,-0.088244945,-0.028490026,0.010690034,-0.031340834,-0.06654564,-0.015844474,0.03225437,0.005228752,-0.12502499,-0.022130616,0.049036965,-0.04441586,0.030425001,0.03924025,-0.065284304,0.07721513,-0.0022649365,-0.14055419,-0.054724984,-0.056979842,-0.04121839,-0.0039615375,0.036306877,0.055933136,-0.0074688112,-0.0776967,0.005927369,-0.007340223,-0.05244896,0.01644481,-0.06923204,0.06292541,0.08146769,0.070626065,-0.021183291,0.08123207,0.022367109,-0.017924992,-0.0069551063,-0.03999482,0.04453336,-0.028805178,0.099463925,-0.02261902,-0.0688775,-0.055661384,-0.03151839,-0.050702408,0.0006394455,0.025497343,-0.05753736,0.047344767,0.00027531275,0.030769043,-0.11320937,-0.0680435,0.018650109,-0.030141242,3.6575068e-34,0.07618561,-0.056287874,0.10101466,0.007109189,-0.055663213,-0.0030681002,0.0774277,0.02046836,0.023406582,0.0041982206,0.0350583,-0.0105334455,0.015140504,-0.066251345,-0.004752528,0.054859713,-0.009271968,-0.005652817,0.058509693,0.04026011,-0.003693155,0.011792269,0.016480174,0.09651126,0.053761203,0.075716525,0.01452238,-0.0019530556,-0.07552723,0.029911192,0.030482544,0.07004557,-0.04148779,-0.061042886,-0.052007284,-0.008271353,-0.09736277,-0.01278196,-0.0069765327,-0.020985939,0.016151197,0.05498444,0.06282519,-0.0045872508,0.010520141,0.042866427,0.027957102,0.024932979,-0.0021861685,-0.041766163,-0.009070528,0.099440955,-0.00797877,-0.04209437,0.04130011,0.01732226,-0.047809716,0.014699099,0.035344053,0.037282605,0.0067929225,-0.06915579,0.014899704,0.10745321,0.030028766,0.10507638,0.046958737,-0.016195957,0.036776062,0.07768746,0.059881773,0.040236715,0.05812127,0.105743006,-0.04496424,0.016713494,-0.05329847,0.07651241,0.00803724,0.014868353,-0.019268366,-0.016083399,-0.04608814,-0.091910556,0.043844398,-0.024019118,0.045906533,0.054757874,-0.007998638,-0.026156204,0.031497672,-0.009735406,-0.027109524,0.037469666,0.07564672,-1.9977723e-08,0.09066985,-0.047100395,0.021396253,-0.09606707,-0.0063670287,-0.0071035447,0.06365685,0.0046283896,0.061157417,-0.0008820098,0.024579087,-0.020273905,0.047039416,0.004775769,0.032485493,0.075822994,-0.01940812,-0.021913694,0.019391755,-0.07981513,-0.04740351,0.001936404,-0.10317189,0.00753118,0.07142017,0.010388294,0.004406259,0.008331364,0.0018802646,0.00193429,0.06103492,-0.033622324,-0.007979489,-0.078628175,-0.0016374547,0.089614056,-0.01480436,-0.025552817,-0.07120053,-0.016167747,-0.08352152,-0.0088831885,0.02011399,-0.038908735,-0.0075784125,0.06274982,-0.060978554,0.019942068,-0.035090562,-0.040864546,0.038964637,-0.0051312405,-0.07638949,-0.080362394,-0.15321009,0.04632519,0.039614286,-0.041317645,-0.012306477,-0.087682545,-0.037958488,-0.054651886,0.07941697,-0.07056297 +2.6.1.66,"Different from EC 2.6.1.42, branched-chain-amino-acid-transaminase.",384,0.99999994,-0.02608961,-0.07147976,-0.04116985,-0.0058433875,-0.0062316614,-0.030510677,-0.07757784,0.1407397,0.024803681,-0.036386557,0.090366356,0.0110132415,-0.04160232,0.02083634,0.00021009192,-0.039673105,-0.049082782,-0.07387816,-0.029537499,-0.010267993,0.07588306,0.048858784,-0.034002036,0.0274271,0.031064501,-0.0015280234,0.002807043,0.031216748,0.06600911,-0.054370143,0.0066049355,0.0012706103,0.016947104,-0.030051688,-0.047729515,0.06595795,-0.0034899188,-0.079519205,-0.033331957,-0.0033774003,0.035448782,-0.007578085,0.01832439,-0.057528116,0.045697898,-0.00438324,-0.022578273,0.00026803015,-0.015214416,0.020792728,0.033589695,-0.114163354,-0.02409139,0.020184606,0.009834071,0.088805914,-0.12583731,-0.00138325,-0.022684284,0.025849886,-0.012489551,0.023672085,0.032292176,0.0029967888,0.042999618,-0.053848412,0.06698231,-0.06441645,0.059560575,-0.05290548,-0.06261264,-0.10523751,0.017139371,0.06954383,0.011457941,-0.011986886,-0.035554375,-0.02706991,-0.028034415,-0.06276193,-0.017585631,-0.06466088,-0.08210323,-0.017073972,-0.0214052,0.005070204,0.07435059,0.027510885,-0.041627165,0.020160025,0.07714245,0.02385606,0.054830454,-0.030229347,-0.072561696,0.034180522,-0.034536418,0.12997818,0.029393375,-0.051810782,0.028341573,0.10373794,-0.05638586,-0.027163496,-0.014537855,-0.014237326,0.03613452,0.07815107,0.014011947,-0.035086382,0.024072075,-0.012266249,0.007148738,-0.05566522,-0.0064971275,0.0832291,-0.005208364,0.012321513,0.061639715,0.08772533,0.026719652,-0.020961547,0.11304392,0.04895487,-0.060205474,0.0033551606,-0.0537321,-4.8558643e-33,0.0056793634,0.004864728,0.06365782,-0.019482626,-0.013115977,0.03216492,-0.13103245,0.04248084,0.014684493,-0.051997792,-0.09121147,0.044708427,0.06589678,0.035047457,0.086412385,-0.0627662,0.0046718107,0.0048741046,0.03162388,0.009683129,0.032681186,0.094561175,0.030620465,0.016144145,0.08836729,-0.06843426,0.019932821,0.0065125795,-0.025686076,0.006974321,-0.05601685,-0.045453798,-0.032134157,-0.023576064,-0.013903464,0.05635551,0.009503695,-0.05484886,-0.018716427,-0.0025909073,0.03875755,0.037930526,0.029573476,-0.009696856,0.03329298,-0.015709296,-0.009570402,0.017555699,0.0039650267,0.010810419,-0.036063958,-0.007574899,0.065429635,-0.016468214,0.03566289,-0.021783322,-0.020828335,0.06822927,0.0060346276,0.1463093,0.023914631,0.12603025,-0.04339487,0.0065636495,-0.0700715,0.056887522,-0.11561529,-0.03972352,-0.051259547,0.024460293,-0.08986544,0.030130923,0.09229429,0.055268515,0.033076495,-0.091588035,-0.11708785,-0.0007996274,-0.012790146,-7.3672945e-06,-0.11882481,0.009975143,-0.040968806,0.017674942,-0.03813168,0.022170518,0.06073881,0.014449659,0.017758364,0.019972095,0.057272963,-0.0041772234,-0.072611906,0.031202422,0.019376608,1.898868e-33,0.021328945,-0.06253389,-0.04911311,0.0086245155,0.04781423,0.01920324,0.07993628,0.015696645,-0.00551699,-0.06378594,0.121110015,0.02006001,-0.016055856,-0.07501734,0.04897683,-0.042782314,-0.096847855,0.023930168,0.04307224,0.03696374,-0.025395697,0.08532803,-0.021806553,0.001164692,0.05290013,0.045604575,-0.016045969,0.045057524,0.09960552,-0.022084145,-0.0267419,-0.00027619977,-0.02445263,0.012809035,-0.06952292,0.05367275,0.0028264576,-0.032526653,0.020536043,-0.054995157,-0.007186304,0.08592516,0.025630627,0.0008177729,0.04232722,0.10095085,0.05304666,-0.010963972,-0.051499538,-0.05180421,0.0812948,-0.057738874,-0.0012670583,0.031222131,0.0036599736,-0.09619899,-0.03126126,0.058482453,-0.03518801,-0.022250174,0.020631272,-0.049783725,0.04636097,-0.05111413,-0.010625442,-0.020249564,-0.030445602,0.036171015,-0.014014089,-0.015274279,-0.011524296,-0.082372874,0.000114819166,-0.024965936,-0.043485444,-0.032956984,-0.044744097,-0.03195191,0.010404306,-0.10903485,-0.079516955,0.033953026,-0.0069730026,0.018386846,0.05415076,0.005076843,0.021212945,0.028347582,0.0034395205,0.011686616,-0.05254777,-0.004221964,-0.11165309,0.097121924,0.063307896,-2.3545605e-08,0.071681656,-0.058251582,0.01474725,-0.032089904,0.073306955,0.006201621,-0.017151812,0.010276447,0.010056354,-0.037109863,-0.03770323,0.07216023,-0.0231584,-0.0018161903,-0.034771428,0.06869751,-0.09219355,0.07712931,0.027333338,0.037393227,-0.07065268,-0.021772955,-0.11357308,-0.041245706,-0.041251276,-0.0242977,0.011149546,0.06855206,-0.010945245,-0.10243862,0.05561791,0.010371339,0.047343317,0.019562159,-0.027104061,-0.0010335529,-0.041109957,0.025158023,-0.05838903,0.054552127,-0.010033179,-0.13085073,-0.081172965,0.028741458,0.0602854,-0.05464945,0.038793843,0.027273579,-0.025624994,-0.039041158,0.03391035,-0.04454032,0.0059246626,-0.06491597,-0.018069156,0.027571859,-0.05887723,-0.10497081,0.04783675,-0.029108845,0.0642886,-0.03728068,0.16550855,0.04042045 +2.6.1.67,"A pyridoxal-phosphate protein. Also acts on L-leucine and, more slowly, on L-isoleucine, L-2-aminopentanoate and L-aspartate.",384,1.0,-0.023568107,-0.14061682,-0.03510418,-0.06441144,0.09556293,0.08954935,-0.024756199,0.0423727,0.09226413,0.01976811,0.062315565,0.03423548,-0.059480816,0.066339694,-0.008428272,0.030927848,-0.040598854,-0.0040022535,-0.032915544,-0.080853395,0.10568618,0.02617631,-0.024449887,-0.02030616,0.046803843,0.04991433,0.004694016,0.007931191,0.0075733517,-0.078340165,-0.033835072,-0.04882512,-0.022170104,-0.082776085,0.058409065,0.055005215,-0.11685821,0.008685361,0.03240566,0.008697684,0.07152957,-0.09873593,-0.030812548,-0.023972612,-0.08109264,-0.011856557,0.01781985,0.036887996,0.011975105,0.0140889,-0.023539178,-0.03234655,-0.055822447,0.010162,-0.06480729,0.045304324,-0.012977099,0.041696213,-0.008982195,-0.00749027,-0.06462637,0.035338134,0.027770795,0.025364082,0.058226876,-0.020092217,0.0014922735,-0.053477373,-0.020364884,-0.02119156,-0.0007356133,-0.040062126,0.0862889,0.021716585,0.056320578,-0.006040738,-0.08069919,0.017698102,-0.037220832,-0.024144584,0.019337669,-0.0031004571,-0.0088503705,0.06928699,0.012253851,-0.045881093,0.0038417638,0.0073583634,0.0013708991,-0.03964705,0.032105003,0.0024045568,-0.02077186,0.03983332,0.0014687624,0.030001758,0.037596997,-0.0029296048,-0.048961673,-0.05290357,-0.02672117,0.017167166,-0.06810593,-0.043290652,-0.06977462,-0.0032037273,-0.06862527,0.017088339,-0.008927771,-0.058154445,-0.003359012,0.015015309,-0.0029893466,0.038913816,-0.022302907,0.0018932653,0.09508237,-0.01494497,-0.045745697,-0.013163056,0.029027816,-0.039793134,0.010905442,0.08779335,-0.043271884,0.03571114,-0.08529645,-5.282477e-34,0.086974725,-0.0077353558,0.019487917,0.041554686,-0.028299462,-0.0035796708,-0.047606535,0.008816852,0.0062967697,-0.0217862,-0.010785409,-0.051173627,0.07118369,0.035290197,-0.09279352,-0.034256343,-0.052514803,0.0015240614,0.05981369,-0.055379737,0.055155363,0.111152954,0.008282632,0.07544788,-0.0016496474,0.045930333,-0.021269638,0.006151324,-0.0359064,0.0019970185,-0.0024401601,-0.089802966,-0.09401358,-0.024959521,0.07489452,-0.05618127,-0.046288513,-0.08202112,-0.011280379,0.020283125,-0.008337178,-0.02423634,-0.048528783,0.00032248988,0.027616361,-0.06718414,-0.025631687,0.059020434,-0.029037204,0.032733522,0.103361085,-0.1009268,0.035963576,-0.03784026,-0.11505088,-1.9601652e-05,-0.09471216,-0.03356319,-0.01433885,0.0633343,0.09221975,0.022631988,-0.036665585,0.023301542,0.01105758,-0.02113416,-0.029991481,-0.07670576,0.027641494,0.04953377,-0.017154543,-0.04024259,0.09992858,0.041645166,0.03700066,-0.026503207,-0.07692689,0.06529112,-0.025551671,0.05148408,0.031582016,-0.0676904,-0.003887902,-0.04516997,-0.044700053,-0.077081375,0.03735696,-0.15697917,0.02770021,-0.022068152,0.013470244,-0.08482704,-0.02784752,0.034115907,0.04153597,-1.884702e-33,0.062248506,-0.11881029,0.121619254,0.023131939,-0.045822646,0.01602687,0.07435727,0.008827814,0.059834465,0.026681509,0.041462287,0.0053218775,-0.029891163,-0.06945346,0.037054744,0.015515108,0.0061680754,-0.011182643,0.07063305,0.072900794,-0.0300854,0.012603294,0.023644071,0.09473708,0.09474046,0.053172447,0.02979353,0.010067363,-0.031759888,0.025050364,0.010955492,0.04744581,0.0071794167,-0.120465964,-0.095622845,0.024835184,-0.07779034,-0.021638596,-0.03351953,-0.056949276,-0.00012213246,0.0149849,0.070806295,0.0052689617,0.032777168,-0.03477252,-0.04041405,-0.030433588,-0.026027327,-0.047425896,0.016626256,0.012305374,0.02292762,0.008131279,0.042444706,0.03897496,-0.05880026,0.016321339,0.06501855,0.021862656,0.003949496,-0.064087294,-0.021527689,0.08343913,0.062337432,0.039516002,0.017037995,-0.025207853,0.07731186,0.07916522,0.09703657,0.015491935,0.07219289,0.09719603,-0.066712715,-0.03609144,-0.034561425,-0.0068890722,-0.022091344,-0.023992036,-0.05953352,-0.022110773,-0.03313492,-0.12958042,0.0104886,-0.048894763,0.020016244,0.106096074,0.01245434,0.005073299,0.00096461124,-0.032144573,-0.00017321712,0.058170855,0.11480196,-3.7058378e-08,0.08163409,-0.01906349,0.024691697,-0.03858106,-0.013521653,-0.03359554,0.06487013,0.0043466506,0.046887003,-0.03418938,0.0060967705,0.031212175,0.06183617,-0.0387699,0.0779537,0.09788172,-0.0057971813,0.02875543,0.0021476774,0.008258794,-0.03192175,-0.0008210074,-0.08701209,-0.008703268,0.049996458,-0.05669661,0.0316673,0.08324096,0.032048926,-0.029449336,0.07465201,-0.020648325,0.060429346,-0.11378338,0.010022428,0.09346991,-0.033676494,-0.058509026,0.01787571,0.017080432,-0.04555739,0.054045055,-0.0038268282,-0.025864257,0.00041253972,0.029888958,-0.039624687,0.010158336,-0.051215574,-0.008753961,0.054907992,-0.046026204,-0.098398514,-0.07344144,-0.09383244,0.04020286,0.013987339,-0.035360936,0.04487169,-0.10516053,-0.047895692,0.0030608168,0.121273704,-0.008341663 +2.6.1.68,"The enzyme from Trichomonas vaginalis also acts on L-lysine, producing 2,3,4,5-tetrahydropyridine-2-carboxylate.",384,1.0,-0.020871758,-0.14371033,-0.091553144,-0.05845031,0.03292705,0.07667518,-0.04273955,0.015237234,0.018027684,0.026506204,0.10094104,-0.09394105,-0.09737162,0.05416963,-0.038380254,0.04331141,-0.044660922,-0.038199097,-0.006155539,-0.024975754,0.085885085,0.0821516,-0.04078721,-0.019452052,-0.0034743776,-0.04364135,0.018747853,-0.024678063,-0.068016626,-0.06819368,-0.044506345,-0.002516776,-0.06516399,-0.06837192,0.06367466,0.005879415,-0.10952821,-0.016818212,0.17013627,0.068744026,-0.006978162,-0.09890113,-0.034221627,-0.01779282,-0.05015443,0.052694056,0.051003765,0.041380607,0.010138966,0.0026491047,0.027464144,-0.013719374,0.036920976,0.08780471,-0.11907853,-0.030258102,-0.054935537,0.07118627,-0.07964309,0.037080254,-0.0012293571,0.09590654,0.04506837,0.020150803,-0.0064923256,-0.03121319,0.0056852913,-0.013233314,0.0069640726,-0.025540462,-0.02978297,-0.019570218,0.03065656,0.04425756,0.040665206,-0.03387053,0.050855197,-0.026717046,0.05571343,-0.020616828,0.006290335,-0.040241692,0.0052765473,0.09844246,-0.019105427,-0.10185,-0.0029131449,0.05142893,0.042521913,-0.06781689,0.050465655,-0.066175334,-0.015922885,0.0036538136,-0.0486461,0.03691252,-0.031582225,-0.034059893,-0.022120522,-0.065262355,-0.059635542,-0.025711302,-0.04090021,-0.047227923,-0.028557444,0.03299024,0.049426477,0.04186663,0.03937523,-0.041417234,0.014096724,-0.005561007,0.06744594,0.024634847,-0.036201622,0.05553152,0.07619593,-0.018933661,-0.015339291,-0.017030053,0.056470808,-0.05644525,0.042995453,0.017740544,-0.07680465,0.029966459,-0.022870991,7.244027e-34,0.04971005,0.010100277,0.005272572,0.016663536,0.05071515,0.048266046,-0.029965589,-0.0152829485,-0.028240431,-0.046747744,-0.08566433,-0.032836296,0.037587743,-0.015943622,-0.052822307,0.061256304,-0.07043165,-0.04964718,0.029746138,0.058466885,-0.011823965,0.110364996,-0.040034465,0.047382295,0.01920044,0.10344075,0.00741707,-0.024621435,-0.016674848,0.023208233,-0.060753666,-0.094123185,0.038219456,0.015280665,0.08175881,0.070826724,-0.0012443642,-0.020901805,0.048986383,0.017714143,0.06414819,0.0090507455,0.010566744,-0.032312665,-0.03683865,-0.013144509,-0.056580067,0.097810365,-0.00910115,0.023864698,0.06775157,-0.03169585,0.014754731,0.012185646,-0.048364043,0.01854513,-0.07206955,0.057279143,0.054464087,0.03261701,0.061161824,0.075254664,0.031752106,0.010339051,-0.045640476,-0.061008174,-0.011937815,-0.0629419,0.036363836,0.039742928,-0.1620587,0.023596652,0.068493605,0.00094758515,0.09072637,-0.055428006,-0.044801563,-0.026845649,0.06498589,-0.026974468,0.03446157,-0.089749515,0.06864077,0.0014328135,-0.019386556,-0.042289883,-0.020251865,0.027756486,-0.0026654094,-0.035246737,0.02038288,-0.034037575,0.076666296,-0.016591365,0.047589183,-1.5379919e-33,0.008946751,-0.036880076,0.029384186,-0.028493103,0.025096947,0.08335433,0.018655127,-0.055107787,-0.037338037,0.04599912,0.073839635,-0.03606355,-0.04486567,0.00612357,0.05584437,0.049659804,0.030743433,-0.044585846,0.013957617,-0.07223665,-0.01280389,0.01473076,-0.011071563,0.018296862,0.04287249,0.029730398,-0.010725267,0.027733862,0.039892484,0.081498526,-0.022255052,-0.01715772,-0.003447054,-0.06239184,0.034735225,0.008181933,0.0029580442,-0.0134461885,0.03261498,-0.0058413413,2.2045035e-05,-0.067117624,0.010143601,0.046088573,-0.049372632,0.037043314,-0.044031743,-0.037672207,-0.016785588,-0.04183362,0.02383197,-0.049675997,-0.07659969,0.0038366362,0.004932893,0.0391205,-0.018205224,-0.038117576,-0.017917428,0.028405875,-0.06754169,-0.07942661,-0.057675418,-0.0148952445,0.028308118,0.014957886,-0.030418584,0.05864541,0.07877848,-0.03971482,0.08963508,0.036428694,0.0557548,0.03406977,-0.10246806,-0.08642776,-0.065775014,-0.113978006,0.070726246,-0.02410664,-0.004888319,-0.06705377,0.05778268,-0.031287502,-0.007333118,-0.09696833,0.0034889393,0.15445805,-0.0099745095,0.0476882,-0.029012987,0.006621995,-0.007092401,0.006226714,0.06762799,-2.9869337e-08,0.03246098,-0.0589703,0.011034605,-0.018795984,0.00350456,0.053694326,0.03266896,0.06905864,0.054408982,-0.04668043,-0.00693942,0.050332207,0.015080848,0.0419473,0.08806836,0.08081741,-0.03164828,0.106143266,-0.017874248,0.016282376,-0.021502847,-0.00608377,-0.096656695,-0.03424969,-0.053960238,0.059021007,0.023229497,0.012998548,0.010982199,-0.0518106,0.033520993,0.032510966,-0.0019629085,-0.023624659,-0.15815276,0.021502243,-0.07871192,-0.014128952,-0.00976921,0.034209523,-0.014846669,0.030374506,-0.04595432,0.02274386,0.023170529,-0.052039772,0.0002913209,-0.035248566,0.035877578,-0.022200463,-0.0132164555,0.0026233776,0.043161727,0.062989235,-0.011464623,-0.043001838,-0.011630674,-0.029842393,-0.0065717637,-0.07280604,-0.08884599,0.09277945,0.16888086,0.01819645 +2.6.1.70,"The enzyme from Pseudomonas putida also acts on 4-hydroxy-phenylpyruvate and, more slowly, on L-glutamate and L-histidine.",384,1.0,-0.022445077,-0.09505516,-0.061116092,-0.0224499,0.019620756,0.1110915,-0.107526384,0.056662098,0.009111203,-0.0029071278,0.08213269,-0.013067841,-0.019943569,0.13396442,0.007983695,0.05971851,-0.08613543,0.012435828,-0.049717218,-0.028426193,0.08486111,0.095128894,-0.05427819,-0.01852022,0.011419609,-0.018468872,0.041154332,-0.03316921,0.04757572,0.0013092208,-0.06720628,-0.09052815,0.038699828,-0.072089925,0.047093958,0.015414399,-0.056568757,-0.030408807,0.10984014,-0.027373359,0.054461572,-0.0016139413,-0.040567417,-0.05048611,-0.0432375,0.006505278,0.08281473,0.017986098,0.027954586,-0.040963523,-0.022211388,-0.05008806,0.0008133067,0.02257802,-0.038995564,0.04799027,-0.039263193,0.022100575,-0.011432559,0.04737918,-0.014882001,-0.023581477,0.027549341,0.04529413,-0.004754707,-0.013461318,0.045110602,-0.012407224,0.00012769364,-0.069348976,0.025184803,-0.046109144,0.12421957,0.016552057,0.007735922,-0.07293017,0.0043185423,0.0025112475,0.0054004863,-0.07651622,0.007090437,-0.06272114,-0.034315046,0.065196946,-0.005897769,-0.08536205,0.0036943574,0.010133969,0.040054202,-0.008335248,0.005687482,-0.029027706,-0.11224881,-0.08115411,-0.023548648,0.032505963,0.014930334,0.009936051,0.028721888,-0.04863731,0.03135155,0.055469938,-0.038706914,-0.048625503,0.0014549261,0.02633789,0.07019958,0.055839404,-0.009041491,0.017282473,0.049782306,0.036467414,0.028679142,-0.009554456,-0.036210336,0.018453162,0.044572953,-0.08632247,-0.09713766,-0.04885921,-0.0072995145,-0.06559086,0.053180896,0.07726328,-0.021275876,0.053371344,-0.087064184,-2.1952233e-34,0.07784984,-0.0033566332,-0.012642878,-0.08119867,0.06278044,-0.0067244964,-0.074369445,0.05617762,0.03595823,-0.031384647,-0.04872089,-0.11190849,0.027823359,0.03173346,-0.04259572,-0.021114774,-0.02141912,-0.040815882,0.0670744,-0.004814288,0.06136319,0.040861674,-0.04282193,0.013107103,0.033804208,0.005931854,0.06709763,-0.03653335,0.009115854,-0.014640138,-0.020943882,-0.073391005,-0.09301064,-0.018503802,0.028153509,0.018279348,-0.07189429,-0.0037725219,0.030036708,0.055355344,0.0628557,0.049379226,-0.052577224,-0.024459131,0.070783034,-0.0488199,-0.034789998,0.15262169,-0.0076235714,0.12353627,0.058028933,-0.10836244,0.037053984,0.05090359,-0.04013469,0.01562817,-0.013645383,0.026935136,0.0393973,0.021301508,0.07382685,0.03182982,-0.03942773,0.047444165,0.04075751,0.010370235,-0.038492255,-0.043978702,0.0155047085,0.0022498535,-0.09216796,0.032469615,-0.003443082,0.029718243,0.0012483357,-0.09873893,-0.094950795,0.043458585,0.02749726,0.0066101276,0.013229182,-0.044637397,0.027180457,0.003779841,-0.064862125,-0.002892687,0.029232616,-0.038966946,-0.062149506,-0.018669162,0.09698924,-0.102989115,0.044679053,0.043276377,0.00096407207,-1.285986e-33,0.023497269,-0.08860222,0.09265073,-0.022235274,0.036125995,0.010399158,-0.03833814,0.076759234,0.0051668244,-0.021092774,0.040721238,0.02347223,0.024160314,-0.022156416,0.040073317,0.055729687,0.0075183418,0.021022674,-0.01196887,-0.03791068,0.011259099,0.0256021,-0.0021405134,0.08893117,0.12358782,0.04730469,0.006600371,0.066241816,-0.009347013,0.13255394,0.012112322,0.03940417,-0.08226845,-0.05125025,0.0485476,0.02476662,-0.0685969,0.013461092,0.041465517,0.0048861485,0.066425644,0.046514552,0.021058915,0.081338525,-0.05350606,0.05523132,-0.11025675,-0.0058978293,-0.023040283,-0.09653827,-0.015663652,-0.02675168,-0.008456678,-0.02292258,0.039176878,0.0024217367,-0.024630584,-0.03612944,-0.087205976,-0.046502035,-0.08576784,-0.14901163,-0.0073203477,-0.0058285664,-0.005591915,-0.016064057,0.00434624,-0.007751237,0.02624761,0.00031158276,-0.0056438698,-0.023895778,-0.04472824,0.060883902,-0.118379585,-0.0011387047,-0.014039546,-0.09448766,0.054174367,0.0033060368,0.01654866,-0.019109957,-0.02406961,-0.10154552,0.026251588,-0.047804683,-0.0381377,0.116813116,-0.006289792,0.017355047,-0.004505248,0.024895199,0.022391232,-0.024360396,0.027287852,-3.159461e-08,0.0709919,-0.07882079,0.09845512,0.053351697,-0.042150695,0.022262199,-0.038281277,0.03984256,0.041478213,-0.083872415,0.0080548655,0.040879723,-0.038833417,-0.030526578,0.0038199064,-0.0006022589,-0.105227776,0.009440062,-0.035673354,-0.04351343,-0.087002866,-0.061203822,-0.101246364,0.046521537,0.034714244,-0.025644157,0.05295522,0.050878685,0.04177092,-0.04553445,0.02264507,-0.017287469,0.0063110096,-0.008804316,-0.048540074,0.03679144,0.04781129,0.0026827964,0.004940371,0.01621463,0.04466741,-0.05332446,-0.07005301,0.0018587247,0.03021731,-0.0050688046,-0.0022932955,0.036890544,0.025636127,-0.0706386,0.05165688,-0.0020370134,-0.0097796805,0.036368597,-0.051951285,0.016832415,-0.014552416,-0.015346143,-0.014851448,0.01299108,-0.028421385,0.11095823,0.12491677,0.043916047 +2.6.1.72,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +2.6.1.73,L-Glutamate can also act as donor.,384,1.0,-0.07400248,-0.08736388,-0.014723994,-0.021582153,0.0050542518,0.028715517,0.069382705,0.08592388,0.018914757,0.021803075,0.059902854,0.001641142,-0.049575683,0.07914729,0.040770195,0.011730847,-0.00063074793,-0.016906818,-0.11068013,0.033445884,0.047595073,0.061646726,-0.014338902,-0.12598377,0.08422075,0.040061012,-0.0012595775,-0.0809712,0.08166412,-0.025123656,-0.046748035,-0.009460305,-0.04312805,0.01071717,-0.033276863,0.03684286,-0.13055994,-0.03085465,0.01388274,-0.009992617,0.028696328,-0.019935556,0.05023919,-0.09040055,-0.05941514,-0.049559094,0.0598592,-0.03163964,-0.02029114,-0.014005488,0.07217164,-0.063669115,-0.0036312344,0.07670005,-0.023467232,0.070966646,-0.055574022,0.0052070613,0.0038245658,0.040903322,-0.053960346,0.06909293,0.012047794,-0.035264876,0.059248127,-0.016224887,0.07427806,-0.0334159,0.031506125,-0.0779709,0.065983996,-0.03918923,0.09092964,0.013355173,0.05172128,0.032612503,0.05021098,0.034968834,-0.0049002767,0.022181155,0.056030344,0.045050617,0.030555334,0.008753695,-0.025788076,-0.00071841804,-0.0696787,0.051786654,-0.051514708,0.02481296,-0.04127364,-0.001831312,-0.044661526,-0.035167236,-0.09299527,-0.024997044,-0.0076059187,-0.027828623,-0.004204502,-0.010040879,-0.009755537,0.11762898,0.038247783,-0.053967886,-0.038575668,-0.015124911,-0.016963588,-0.034217637,0.001846395,-0.06753131,0.024770651,0.033663962,0.051175483,0.031245714,-0.046547573,0.026918825,-0.019639354,-0.0771341,-0.096388385,0.010936856,0.0075090295,-0.06007164,0.014199527,-0.024428105,-0.028620886,-0.010746396,-0.06341482,-1.9133204e-33,0.020781724,-0.02629928,0.02886825,0.01259803,0.032781504,0.028259758,-0.045523267,-0.04289185,0.04375878,-0.08529373,-0.10634673,-0.05194015,0.02020775,0.056190092,-0.09845063,0.06425621,-0.10077921,-0.076215476,0.05874132,-0.015639858,0.031392574,0.043550327,-0.029825926,0.005498163,0.013632184,-0.005778868,0.03627808,0.03588308,0.05239765,-0.008112944,-0.046811033,-0.050355203,-0.0245084,-0.0253834,0.008103503,0.04414938,0.018846665,-0.067521356,-0.016383056,-0.0053162794,0.057457786,0.039643217,-0.05184999,0.042913,0.05387665,-0.0077832625,-0.050803125,-0.099212445,-0.10537429,0.079764836,0.030657964,-0.104962595,0.004321495,-0.04151899,-0.04320283,0.004604114,-0.032362018,0.01139877,0.036240745,0.038165156,0.03365264,0.036955528,-0.011623154,0.05475992,-0.009672713,0.041132063,-0.0039881314,-0.124541596,-0.05633906,0.004345394,-0.032100264,-0.0945436,0.025500601,0.007376019,-0.03409105,-0.0623947,0.011589281,0.052418012,0.07031993,0.022432767,0.01744856,-0.049853873,0.03233141,0.048087105,-0.016890872,-0.043112095,-0.017603341,-0.14146322,0.0069940244,-0.088516094,0.009979801,0.0075395205,-0.013659206,-0.0787021,0.0067352806,-5.652771e-34,0.06361552,-0.06812401,0.043742094,-0.0007809187,0.06565092,0.041282564,0.042182468,-0.073544,0.056501392,0.05281227,0.0062381406,0.04122565,0.05408068,0.013125098,0.040125098,-0.046610467,-0.037804067,0.0057487637,-0.046868313,-0.0059089274,0.008012475,0.09664462,0.09045061,0.0144128455,0.056164365,-0.0148085905,-0.05102051,0.021746192,0.024548838,0.015921645,0.027204819,-0.007631237,-0.09940288,-0.08678892,0.005735915,0.026540672,0.086278796,-0.008206369,-0.06428858,-0.051711243,-0.008116304,0.03126081,0.1040353,0.06956833,-0.03870754,-0.007211935,0.048412643,-0.06562837,0.014350426,-0.023488643,0.024140805,-0.0040989444,-0.016536228,-0.042396203,0.043871503,0.031358637,0.10503441,-0.07796925,-0.0075427424,-0.07746096,-0.085703835,-0.08028959,0.01892138,0.007747986,0.02643818,0.00971475,0.16342992,0.029215261,0.06466664,-0.0024483404,0.11333308,-0.025427198,0.011295299,0.053294305,-0.0523401,-0.022390798,-0.05383703,-0.024202904,0.05503055,-0.11711238,0.010633174,-0.06212331,0.008307762,-0.027891098,0.0973704,-0.09717214,0.0035841675,0.09490036,0.015894253,0.016511902,-0.0793394,-0.03716524,-0.00020498315,0.022769827,0.05695438,-2.0445738e-08,0.012379577,0.014203089,-0.050428875,0.025650257,0.014212348,-0.0032819903,-0.10075608,-0.0011691637,0.049775485,0.046493102,-0.0035321747,0.10584207,-0.037943073,0.034706112,-0.00012347357,0.043301348,-0.018694371,0.00040895146,-0.037266452,-0.041721776,-0.06852584,-0.02272882,-0.032795433,0.062467236,0.056714095,-0.024371758,-0.0030928026,0.09482222,-0.017105198,-0.050113253,0.022738451,0.043860864,-0.032019865,-0.0009907493,-0.02160227,-0.013965717,0.13443919,0.0038135557,-0.029273584,0.012468537,-0.021708172,0.03558553,-0.017738331,0.056914054,-0.0609242,0.022970904,0.04556321,0.00042658593,-0.0024156002,-0.01431344,0.06673016,-0.06319263,-0.006824142,-0.01502827,-0.10509228,0.026072424,-0.011321897,0.05982466,0.11712552,-0.05869805,0.01577161,0.08295729,0.07639112,-0.005411298 +2.6.1.74,"A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor.",384,1.0,-0.056828544,-0.100465916,-0.003373062,-0.085868984,0.052779403,0.031433288,-0.023706421,0.08056143,0.059006087,0.029015098,-0.0042539285,-0.087679535,-0.0935049,0.06790103,0.03966869,-0.027725784,-0.055783987,0.030777074,-0.076704025,-0.031085853,0.008037764,0.0026744534,-0.0018716593,-0.04043585,0.068339005,-0.0021873838,0.034964163,0.012707174,0.061431266,-0.021765161,0.0005655392,-0.11411437,-0.02400187,0.008616671,0.013133118,0.04863297,-0.031605802,-0.005077084,-0.049500264,0.0068139215,0.031365953,0.035871748,0.059016023,-0.027915535,-0.03352514,-0.014228588,-0.032066353,0.050418224,0.028768012,-0.0015567212,0.06902439,-0.082424656,-0.0008173491,0.043606855,-0.0021095166,0.103047185,-0.04334809,-0.005466112,-0.056691382,-0.044449575,0.0089603765,0.016736703,0.056567423,-0.04275744,0.034087803,-0.012097749,0.012216704,-0.052738473,0.08221474,-0.09752798,-0.036856327,-0.10388565,0.06845318,0.11340122,0.046085097,-0.001280323,-0.027821615,-0.042113844,0.017019022,-0.087872885,0.040436126,0.011340448,-0.024770696,0.07239031,0.017731285,0.045978174,-0.00090342655,-0.003126045,0.0028707748,0.009418826,0.008112138,0.0006148431,0.02200336,-0.06835021,-0.102774315,-0.0047110855,0.039048504,0.105254956,0.006754752,-0.007493011,0.004830468,0.13873622,-0.074368834,-0.058268297,-0.09259795,-0.04070009,-0.043392416,0.011326739,-0.0073628356,-0.06746334,0.037835233,-0.0094234375,0.06364313,0.01870987,-0.032546263,0.010960058,-0.0087479325,-0.06582607,0.009430657,-0.032308523,0.013216523,-0.016536789,0.16278496,0.07417002,0.033300053,0.072841935,-0.057976108,-7.227699e-34,0.035766207,-0.021638757,0.025650905,0.030673424,-0.033745788,-0.025122942,-0.086086236,0.07980363,-0.00157256,-0.107976004,-0.15981032,-0.058650535,0.07201335,0.019687722,-0.00018485452,0.022722451,0.04164657,-0.05346426,0.03362222,-0.017795108,0.05313677,0.10262088,0.023646742,0.06316102,0.07623838,-0.04330199,-0.048624802,0.06662394,0.07953966,0.008788754,-0.1223156,-0.028260192,-0.056367118,0.011731177,-0.038432676,0.038317602,-0.03127579,-0.01122415,0.03451198,0.052227043,0.043194458,-0.013938742,0.03429915,-0.020218212,0.03192041,0.0057965177,-0.022999113,-0.03771656,-0.04823673,-0.0011546895,0.0505967,-0.06644703,0.02470008,-0.07831984,-0.028923607,-0.031482663,-0.027943596,0.0040837065,0.07223606,0.101778775,-0.023363974,0.0683389,-0.025635477,0.04505222,-0.01551385,-0.013865072,0.008501587,-0.0411148,-0.06412459,0.020699855,-0.07334911,-0.030165635,0.03925142,0.06660024,0.016006978,-0.08243166,-0.0020397296,0.03178731,0.041594733,-0.060934447,0.006930101,-0.010218295,-0.033916168,-0.0074790474,-0.00015907055,0.007742824,-0.0077054533,-0.10688447,-0.0058053066,-0.033633474,-0.02264562,-0.06016498,-0.083222024,-0.02530836,0.028378358,-8.7311505e-34,0.0015020998,-0.054373708,-0.036286805,-0.00655483,0.024475928,0.06388722,0.03957661,-0.03133785,0.09163765,-0.058160603,0.09782125,-0.03396109,-0.008493439,-0.040737424,0.009542867,-0.03134675,-0.10340207,0.016995082,0.01415671,0.012267217,0.011579248,0.03298663,0.004363403,-0.05557614,0.062078618,0.005184287,-0.034961674,0.089506626,0.09330517,0.059773237,0.021095194,0.033396564,-0.05313918,-0.0069178953,-0.08922193,0.07896458,0.004109085,-0.012611121,-0.018152198,0.017872311,-0.03112779,0.04776647,0.09095024,0.08137887,0.017620055,0.057644427,0.009246922,-0.04995056,-0.007562686,-0.0047068484,0.070385955,-0.0943829,0.06564224,0.018163426,-0.018833876,0.059125338,0.05285032,0.04480608,-0.026337724,0.02201442,-0.039680764,-0.08941842,0.049331546,-0.020143257,0.0028440566,-0.043866422,-0.023562727,0.07728747,-0.0081711775,-0.026474774,0.084002234,-0.090168074,0.02027591,0.031696096,-0.051451046,-0.05664496,-0.04825533,0.07748511,0.04156372,-0.052042615,-0.08096044,0.0021154594,0.041186705,0.038948793,0.059096552,0.009209083,0.033463985,0.04102457,-0.0026413747,0.050859325,-0.072971255,0.00069893163,0.042007994,0.07749735,0.102266215,-3.710826e-08,0.08358111,0.011559265,-0.015463134,-0.0015681185,0.06949906,-0.019942269,-0.06726987,0.024953779,-0.00799235,0.0034858098,-0.06880539,0.088800326,-0.056667875,0.040913064,-0.049795464,0.10353246,-0.076750234,0.02451946,-0.04091794,-0.012990366,-0.03168915,-0.00717387,-0.10272641,-0.01381612,-0.032000605,-0.0015278682,0.0115809,0.05602002,-0.044217933,-0.03223307,-0.03125054,-0.017639391,-0.010812239,-0.016215507,0.012593207,-0.0066237114,-0.027926471,-0.03722563,-0.023362199,0.017762883,0.038152978,-0.052633792,-0.080521226,0.06092327,0.019178184,-0.00895505,-0.0021908092,0.027830599,-0.045866076,0.06267518,0.05449306,-0.06812665,-0.0023503096,-0.057902347,-0.10812112,0.03121065,-0.05478942,-0.022431403,0.07796865,-0.056826007,0.0048719263,0.02031626,0.11695337,0.003981717 +2.6.1.75,A number of cysteine conjugates can also act.,384,1.0,-0.017347833,-0.09834209,0.021830766,0.024026217,0.029429637,0.04439295,0.022871032,0.04082995,0.07229216,0.007622642,0.045128435,0.040149868,0.020138508,0.06362017,-0.037656844,0.052735142,-0.06903904,0.03308128,-0.06438788,0.0719552,-0.0059293024,-0.04189948,-0.03645574,0.024492882,-0.032113723,-0.028684577,0.010309087,0.011452216,-0.035342928,-0.052072383,-0.09574105,0.0021705118,-0.0542604,0.07558549,0.030531872,0.073536925,-0.07371377,0.040080488,0.03727552,-0.029330645,0.04785198,-0.029062236,0.026490321,0.0218281,0.010573942,0.029412674,-0.0076155933,0.04829268,0.04595136,0.03357553,-0.06770789,-0.04579158,-0.006619974,0.10630521,-0.013242386,-0.0010133206,-0.14195554,0.02843362,0.03493062,0.052910924,0.018176556,-0.05693748,-0.023502141,-0.014323201,0.035524573,-0.011284192,0.033421487,-0.008827281,-0.054223716,0.010816133,0.08741595,-0.00029434817,-0.047284264,-0.007719721,0.015520012,0.07232863,-0.093903,-0.06443662,-0.018430255,-0.03870566,0.0019855849,-0.0025458396,0.029137867,0.018492518,0.08653986,-0.048926212,0.023658857,0.0036317087,-0.05277474,0.08129855,0.021721255,0.033673473,0.0045577437,-0.0317336,-0.08980848,-0.0011694988,0.04462655,0.09895095,0.033435535,-0.005272652,-0.0041380376,0.047222704,0.0062996102,-0.051626164,-0.09780054,-0.050738383,0.03176148,-0.009967656,-0.105889775,-8.8288216e-05,-0.04089422,-0.079649866,0.09518908,-0.038775623,-0.006491235,0.09223735,0.0670583,0.02031084,-0.026092503,-0.023113593,0.013392637,0.0028346835,0.029936451,0.070767656,-0.047535554,0.03024933,-0.061463278,-1.0124078e-33,0.06570572,-0.013203929,0.016097859,0.06677805,0.017704869,0.0038202186,-0.04363472,0.021026606,-0.03582093,-0.07512142,-0.003526184,-0.04911766,0.084342815,-0.102963075,-0.02468344,0.00071207795,-0.04753106,-0.07539522,0.024041457,-0.03390188,0.031953264,0.13735788,-0.06935758,-0.021211442,-0.048695005,-0.01517718,0.01757365,0.013613349,0.014755548,0.005487708,0.018615974,-0.054066814,-0.06805213,0.028495438,0.061781853,0.077305384,-0.042005338,-0.02078187,-0.032592423,-0.036662,-0.050269663,0.018690303,-0.0012690456,-0.08467431,0.017015738,-0.067453265,-0.023192614,0.030277262,-0.098748505,-0.0032043722,0.11889538,-0.024715085,0.038981944,-0.03275757,-0.040778488,-0.011530731,-0.017161608,0.00031127327,-0.005264881,0.11744615,0.0140211275,-0.005508505,-0.07426424,0.014265463,-0.05878921,0.045704186,-0.13376127,-0.07204169,-0.024669025,0.10035573,-0.041984454,-0.024292288,0.037372325,-0.0015844629,-0.001975245,0.00014005908,-0.038393214,-0.036345217,0.015067143,0.060892366,-0.0956586,-0.06905952,-0.013032098,0.06394594,-0.033830717,-0.01827212,0.02532612,-0.10004653,-0.061679073,-0.023717334,0.071730874,-0.07291051,0.010744614,0.01088805,0.00031026936,-1.2642851e-33,0.021009358,-0.0809622,0.051799905,0.020400649,-0.033582494,0.082591474,-0.011934306,-0.057735883,-0.0020004811,-0.058270317,0.06998539,-0.029386522,-0.024978114,0.04208551,-0.026827106,-0.014211938,0.0030216074,0.10801829,-0.024604432,-0.010678548,-0.09216665,0.086888395,0.08172246,0.11739349,0.021529796,0.051230256,-0.025448272,0.074749336,0.057704862,0.15510449,-0.050326526,-0.01888247,-0.02878835,-0.0045459745,-0.007285789,0.053634256,0.038594585,0.0017469069,0.0485949,0.010558525,-0.015560113,-0.036851242,0.08123604,0.13631009,0.015646022,0.045215063,0.027466813,0.092119634,-0.0879425,-0.001535057,-0.008715291,-0.015720302,-0.06884365,0.0023790137,0.030809132,0.06192382,0.023738328,-0.019395169,0.008218318,-0.03775847,-0.031401675,0.00036076442,-0.033789072,-0.09045127,0.05486432,0.012531304,-0.09843377,0.02821176,0.018384987,-0.0015038799,0.006927747,-0.026247853,-0.052997805,0.03897198,-0.016161395,-0.056031942,-0.0032020193,-0.0048625492,-0.0005332664,0.02259027,-0.035679076,0.005324537,-0.008069212,-0.04854544,0.032130685,-0.024000833,0.039116435,0.033230476,0.012390435,0.03019053,-0.030167762,0.076944485,0.065973684,0.06295195,0.020527732,-2.1053847e-08,0.08108855,-0.06698996,0.039663415,-0.097848006,-0.035219792,-0.021379465,0.010927427,0.03895915,0.005488667,0.03873941,0.05106206,0.049174886,0.0028688693,0.006976972,0.026111687,0.019225426,-0.018610626,-0.016970268,-0.053635158,0.010394064,-0.0755067,-0.060952764,-0.097081535,0.03290326,-0.077105194,-0.058376882,-0.024302606,-0.041064348,-0.10306106,0.02164135,0.094627276,-0.04598095,0.03046524,-0.019093663,-0.11522804,0.061737522,-0.038317513,-0.068102255,-0.032816984,-0.020400347,-0.014504913,-0.024692057,-0.092333406,0.059727833,0.0099241035,-0.07352555,-0.02046783,0.0025845447,0.021943422,0.08609777,0.029306676,-0.006948084,0.057960417,-0.025341732,-0.04049999,0.014513892,0.05492146,-0.016192302,0.068148024,-0.07558448,0.02444612,0.025711242,0.1429884,0.011322645 +2.6.1.76,"A pyridoxal-phosphate protein that requires potassium for activity [4]. In the proteobacterium Acinetobacter baumannii, this enzyme is cotranscribed with the neighbouring ddc gene that also encodes EC 4.1.1.86, diaminobutyrate decarboxylase. Differs from EC 2.6.1.46, diaminobutyrate---pyruvate transaminase, which has pyruvate as the amino-group acceptor. This is the first enzyme in the ectoine-biosynthesis pathway, the other enzymes involved being EC 2.3.1.178, diaminobutyrate acetyltransferase and EC 4.2.1.108, ectoine synthase [3,4].",384,1.0,-0.05606637,-0.03024878,-0.12202881,-0.052852955,0.016944328,0.058777586,-0.056488596,0.04646537,0.027140265,0.019102914,-0.031010719,-0.0732476,-0.09107514,0.017993681,-0.003312911,0.040900297,-0.066285044,-0.002750404,-0.011493619,-0.057825275,0.053867333,0.0062770434,0.0033703698,-0.056385852,-0.0007382631,0.026842598,0.05786358,0.01445064,0.005873841,-0.07228602,-0.029351832,-0.10011349,0.046931006,-0.017475137,0.068427205,0.0932286,-0.106393605,-0.13653506,0.06533237,0.008378923,0.10512768,0.05842389,-0.025720567,-0.03226576,-0.0078104287,0.0052769682,0.03669733,0.016455231,0.049981747,-0.056061056,0.0112166405,0.016635787,-0.048516624,0.052797563,-0.018755391,0.038065158,-0.00018982636,-0.042317357,0.012258441,-0.013570999,0.026906503,-0.007161234,0.076344,-0.028645905,-0.009431167,-0.039314635,0.0012812332,-0.062043954,0.026100347,-0.062374145,-0.10681341,-0.068411626,0.043064658,0.100886874,-0.009925601,0.014159446,-0.004089395,0.03303172,-0.035111077,-0.05847166,-0.023505945,-0.04443214,-0.056349643,-0.009449322,-0.012685303,-0.069315635,0.021685002,0.011763933,0.033762928,0.035777014,0.060694076,-0.023146452,0.043338645,-0.021990487,-0.026588853,0.020137038,0.027846012,0.010745023,0.0051102927,-0.05270556,-0.04288796,0.07910262,-0.024222352,-0.03322661,-0.044081252,-0.045125414,0.01872601,0.10796221,0.023240265,0.0507866,-0.0338494,-0.0622316,0.023881247,-0.0066186967,0.02772611,0.029573075,-0.0012412091,-0.013979169,-0.019457426,0.067680925,0.077633426,-0.056701355,0.092194475,0.028069437,-0.04607815,0.054654386,-0.15646432,4.925487e-33,0.09093293,0.01433411,0.064791225,-0.02773329,0.04527956,0.02226701,-0.14674327,0.04408875,0.056254923,-0.044674024,-0.10314534,-0.061132226,0.1079907,-0.02584469,-0.062166393,-0.014259293,-0.08514742,-0.013880872,0.069629036,0.009568264,0.05008656,0.03317762,-0.0065064277,0.077062115,0.023297522,0.050482936,0.027641272,0.024626808,-0.0012136704,0.009674232,-0.013897167,-0.10571343,-0.09183659,-0.051284865,0.058390006,-0.018210053,0.029187607,-0.032402553,-0.042130712,0.050918225,-0.049203526,-0.021792702,-0.031005295,-0.018903965,0.09403652,-0.078691915,-0.016351288,0.10795045,0.04306335,0.02906219,-0.005917589,-0.06329364,0.099786654,-0.026131371,-0.027447276,-0.013307573,-0.017067589,0.007836562,0.07368328,0.01512348,0.10192741,0.052334145,-0.025984166,0.0051368237,-0.030344851,0.028567852,-0.061297588,-0.043934293,-0.029266626,0.03322803,-0.07207971,0.017618665,0.07350756,0.026469542,0.03200238,-0.03636073,-0.09815976,0.016450768,-0.017980827,-0.012249663,-0.05949242,0.015277014,0.03503804,-0.026401747,0.011299116,-0.06059754,-0.038572416,0.017917132,0.020043202,-0.007720256,0.038834605,0.004781479,-0.07323734,0.057538804,0.023479652,-4.959846e-33,0.099591255,-0.03924116,0.006282478,-0.0589756,0.04942866,0.027071988,0.053403627,0.04395064,0.017240532,-0.059027527,0.08461391,-0.027190665,0.038341004,-0.040351447,0.07148368,-0.0026417668,-0.05736036,0.107216604,-0.00052016415,0.024492819,0.031070221,0.038278304,-0.044217456,-0.022576956,0.022235343,0.042604163,-0.0035584588,0.05667409,0.003503606,0.040784262,-0.008331547,0.07667055,-0.08015366,-0.06362499,-0.097555734,0.009999075,-0.07839669,-0.0062219356,-0.0048074964,0.021603586,0.062140457,0.09297318,0.016587691,0.05922431,0.028048366,0.024181288,0.019436568,-0.010556788,0.0012842648,-0.060541935,0.005886963,-0.054426163,0.003458006,-0.01770471,0.04390582,0.044654675,-0.012748266,0.061637208,0.03137562,0.03583192,-0.011842232,-0.0987773,0.13789546,0.032809433,0.012295261,0.013680441,0.011268738,0.07732085,0.07109472,0.038563557,0.045221806,-0.023346564,-0.033639215,0.03729266,-0.025288755,0.055361502,-0.06610009,-0.0012902585,0.027317626,-0.051935177,-0.039161224,-0.0033155899,-0.028472947,-0.06946864,-0.012767337,0.013405694,0.01229082,0.061222624,-0.013744082,0.033024948,-0.06182642,-0.07362913,-0.015316456,0.092012264,0.03582905,-4.7336474e-08,0.040494274,-0.011304024,0.020405065,0.025278023,0.08295931,0.024716426,-0.05258335,-0.0027184058,0.072569855,-0.11967916,0.030503308,0.026417043,-0.006103197,0.020880459,0.06470562,0.0771151,-0.060364015,0.0596097,0.015398882,0.06380191,-0.037092526,-0.05707832,-0.12547196,0.03460439,0.056980476,-0.047852665,-0.027324904,0.04494761,-0.037288148,-0.027164057,-0.008035378,0.00033869862,0.03930509,-0.024369689,-0.059420377,0.015175678,-0.036518943,-0.02097903,-0.028493978,0.0012545522,0.027821004,-0.11136093,-0.039293487,0.00016753229,0.017474115,0.059010915,0.010070123,0.021908745,-0.090473935,-0.087391734,0.036143,-0.067697085,-0.038797516,-0.057951048,-0.07090339,0.066165775,-0.04057205,-0.0691489,-0.021412356,-0.021328224,0.012391976,0.021626696,0.13284616,-0.0099820355 +2.6.1.77,"The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.",384,0.99999994,-0.00597159,-0.021222185,-0.024871442,-0.06060265,0.052726924,0.02932643,-0.026372734,0.009462288,0.023114469,0.043420352,-0.014655766,-0.0039925696,-0.08583755,0.08522568,-0.06467438,0.116221435,-0.09751987,-0.031397667,0.042412907,-0.028759385,0.07221651,0.041570574,-0.057853024,0.0014759455,0.048823375,0.03196661,0.024757767,-0.03167359,-0.03899567,0.005675399,-0.04171922,-0.079025805,-0.017214114,-0.09590607,0.02419827,0.0853003,-0.019769484,-0.020500643,0.06460958,-0.007814728,0.037949044,0.048705693,-0.03177916,-0.023052419,-0.03779927,-0.038505696,0.037565544,0.006492154,0.06666051,0.0007223165,-0.0435416,-0.013276318,0.0052635483,0.0055870456,0.04543124,0.095860146,-0.052262686,-0.0450424,0.010814152,-0.07650864,-0.0037528959,-0.032599717,0.022338808,-0.08816001,0.04341705,-0.044022523,-0.007839808,-0.027283391,0.10732295,-0.015781907,-0.09502164,-0.006850146,0.022793012,0.027903397,0.0031095531,0.0043717693,-0.039940927,-0.037918765,0.058728468,-0.05241461,0.00033326066,-0.049644917,0.04484111,0.056035805,0.11245103,-0.029425122,0.045436837,-0.040512327,0.015095274,-0.049787685,-0.011278152,0.008625999,0.038259946,-0.057513516,-0.011077427,-0.014136403,-0.012399525,0.060533885,-0.014114057,-0.029687665,-0.021338293,0.057440873,-0.021629967,-0.11229191,-0.07059423,-0.01921788,0.010800653,0.112704776,0.083240025,-0.0029440492,-0.010472001,0.014285797,0.05031162,0.069945656,0.047007486,0.0775176,-0.0032099495,-0.07592054,-0.0825482,0.020553216,-0.0057432614,-0.009775607,0.050283697,0.008526108,-0.032514036,0.049380053,-0.08768445,4.8258077e-33,0.10134267,0.07776996,-0.009112507,0.043540455,0.010830074,-0.042576183,-0.114263445,-0.014869552,0.06562698,-0.07638953,-0.02905682,-0.085123554,0.020945152,0.040655766,0.007900676,-0.0018540417,-0.029720906,0.013178021,0.1019382,0.038094766,-0.042346172,0.08841104,-0.030738933,-0.029978562,0.07896555,0.0013083685,-0.022053437,0.01928859,0.007889344,0.023547428,0.050776843,-0.06300267,-0.118048325,-0.007737651,-0.020348923,-0.020117521,-0.056481153,-0.040817868,0.013415314,0.011823411,0.076500565,0.020290684,0.046802774,0.023645306,0.05993489,-0.023886867,0.023000252,0.08043094,-0.030596223,0.09865102,-0.012602829,-0.018010417,0.06691497,-0.073227875,-0.08554254,-0.05290513,0.04096166,-0.054868978,0.06358305,0.09073504,-0.0008714189,0.0650718,0.0012447685,0.0016333407,-0.01879434,-0.041973393,0.025033057,-0.0495744,-0.013834547,0.05141409,-0.03745806,0.0076662065,0.013613683,0.067928076,-0.0434087,-0.09075547,-0.016524874,0.03792235,0.01089023,-0.069824725,-0.0002650497,-0.03155299,0.0135957915,-0.017063932,-0.034177482,-0.013580301,0.037613586,-0.032267082,0.012675888,0.03244246,0.0056731757,-0.05817583,-0.07168507,0.052211348,-0.002769306,-3.78152e-33,0.07283992,-0.122227624,-0.0047680084,-0.09333632,-0.08387115,0.069280356,0.033559434,0.02234421,0.053540934,-0.062824,0.121486284,0.050549574,0.027160063,-0.017399823,0.04911057,-0.056054983,0.037046615,0.014551827,0.028588502,-0.07540583,0.06515235,0.090713665,-0.020608686,0.032584954,0.057049904,0.073833615,0.012150924,0.011612803,0.11678906,0.003047953,-0.015684156,0.041834876,-0.00582515,-0.05881779,-0.034664407,0.013016042,-0.014041032,-0.019463426,-0.015193793,0.020857807,0.041894604,0.03528893,-0.03450934,0.044178475,-0.03328528,0.029244015,-0.002730803,-0.035676032,-0.007734978,-0.048329666,0.08311683,-0.07906371,0.00073013897,-0.003968404,0.007099,0.025286883,-0.017422698,0.0031276713,-0.020049378,0.00321382,-0.065140665,-0.0039901705,0.025784394,-0.038105913,-0.009853644,0.022746682,-0.010257031,0.03813144,-0.007945788,0.011406181,0.033626225,0.01744022,0.06385579,0.06639975,-0.06520662,0.0002444845,-0.055483665,0.027047688,0.051665455,-0.07615444,-0.05986768,-0.023052134,0.027642377,-0.03664291,0.05212175,-0.08682348,0.023894148,0.109639056,-0.030548302,0.030740537,-0.00408105,-0.067791596,0.004831205,0.09865884,0.04728426,-4.3113822e-08,0.02637918,0.024900697,0.051935572,0.0003725964,-0.051931836,0.05108634,0.030235952,0.02852117,0.029899277,-0.04067902,-0.07611471,0.05440398,0.0064580385,0.006157,-0.05844698,0.07947782,-0.0773331,6.1711085e-05,-0.04651734,-0.04867393,-0.1302352,0.0005404453,-0.09148302,0.056892775,0.012338589,-0.036656138,0.10285364,0.0015027287,-0.030003924,-0.043198884,-0.01787267,0.03379284,-0.04711285,-0.04193538,-0.053607292,0.0021314772,0.030333528,-0.044271354,-0.0070150313,-0.012523234,0.025198981,0.00066875445,-0.1254225,-0.004312592,0.09132396,-0.03097058,0.0020290224,-0.04109134,-0.057834793,-0.024608359,0.10771656,-0.012450587,0.03298645,-0.05116521,-0.13702996,0.033326868,-0.024944182,-0.104710534,0.033767935,0.011904631,0.07103033,0.027823426,0.19259307,-0.018208336 +2.6.1.78,"A pyridoxal-phosphate protein. Glutamate can also act as the amino donor, but more slowly (cf. EC 2.6.1.79, glutamate---prephenate aminotransferase).",384,1.0,-0.04939366,-0.10839922,-0.028334456,-0.10117256,0.004567165,0.04179202,0.04144501,0.05435771,0.07237996,0.049688898,0.08809376,0.0036591988,-0.06060039,0.1060837,0.044044927,-0.00030358456,-0.03099575,0.0063480646,-0.036421623,-0.032963704,0.063214935,0.08796107,-0.041292474,-0.08578581,0.048575897,0.054044098,0.03766286,-0.038103074,0.0599252,-0.0074845925,-0.059192188,-0.035790104,-0.047972545,-0.0035409196,0.015006497,0.108935945,-0.1159919,-0.052668367,0.023887431,-0.059104394,0.083770074,0.022385858,0.03264988,-0.041227423,-0.06953773,-0.037860785,0.13758071,-0.013971687,0.019331807,-0.06880361,0.0022997742,-0.039869715,-0.029348075,-0.019189104,0.019473521,0.07304649,-0.024214452,-0.018636493,-0.021699913,0.0017631738,-0.094766594,-0.0020589754,0.03138739,-0.039402556,0.0785324,-0.011649293,0.07224606,-0.052039012,0.025449172,-0.07017392,0.002653843,-0.0234888,0.111867726,0.03151124,0.014161394,0.024592478,-0.037536815,0.046147738,-0.015896386,-0.035180185,0.034023453,-0.0054762396,0.030697158,0.03878585,0.04806254,0.030206582,-0.03787299,0.0774209,-0.035376597,-0.020224879,-0.00439357,0.016081149,0.020109737,-0.028422363,-0.09015822,0.013887179,0.002176289,-0.008740168,0.01075028,-0.01537287,0.020848123,0.118245274,0.01054487,-0.038391475,-0.059382573,0.020879317,-0.010986247,0.03742585,-0.04391577,-0.012434828,-0.029675376,0.03680053,0.044982217,-0.0003483389,-0.035753153,0.022439253,-0.0038658464,-0.0266671,-0.05967257,0.042574134,-0.022051824,-0.008803561,0.0110825235,0.090750776,-0.04048687,0.032756925,-0.08695741,1.6073647e-34,0.016967213,-0.0054104677,0.060636178,0.010246306,-0.005462523,-0.017606156,-0.035346635,-0.033568166,0.043035783,-0.06635304,-0.08669119,-0.08339082,0.032368116,0.03505402,-0.047627773,-0.0036530416,-0.09750279,-0.007516041,0.07241332,-0.038785487,0.024610914,0.04954482,-0.00081552804,0.030056229,0.037930492,0.003578168,-0.018339133,0.016436422,0.021272307,-0.011035056,-0.046553545,-0.06937282,-0.08402196,-0.07066493,0.018946975,-0.081999056,0.010342436,-0.086799614,0.021298036,0.04516458,-0.030823512,-0.030970402,-0.05747572,0.064301744,0.06701293,-0.034621388,-0.042207234,0.008772632,-0.10075668,0.05881384,0.052142825,-0.12241004,0.028613457,-0.03023337,-0.1268129,-0.022476187,0.0111156255,-0.037247755,0.0511107,0.083292544,0.03184848,0.015461491,-0.04732797,0.0011038535,-0.017670656,0.0014591987,0.013776084,-0.11458096,0.018595692,0.06650514,-0.002732155,-0.053679798,0.025154907,0.028128063,0.027077178,-0.09035875,-0.043195613,0.019326754,0.049401555,0.034198914,0.008286578,-0.01882063,-0.03312668,-0.01686102,-0.039390165,-0.047264002,0.0401955,-0.13789332,0.00035249023,-0.027074536,0.012532678,-0.06982998,-0.06587497,-0.019909702,0.0044184476,-6.100672e-34,0.10190798,-0.075704865,0.02500487,0.0031056206,0.0017811521,0.015058857,0.09001045,-0.047162145,0.05315393,-0.017684113,0.04440105,0.0013726149,0.07932661,-0.055411935,0.02693089,0.012752922,-0.049032874,0.013097259,0.041135482,0.012975497,0.035406586,0.024153803,0.03802853,0.04050187,0.03858359,0.029714124,-0.06397822,0.076791696,0.0024431704,0.035932697,-0.029800447,0.04236808,-0.046765294,-0.094114676,-0.054082513,0.02914348,0.01562532,-0.0149669,-0.06051476,-0.024979407,0.04466053,0.12312446,0.10781729,0.023300791,-0.0562959,0.05208833,0.018470746,-0.029515062,-0.017752538,-0.026670253,0.06687568,0.051894333,0.0040457295,-0.02702552,0.04222466,-0.018561676,0.027572015,-0.05971254,-0.007100095,0.008569271,-0.083721906,-0.12475797,0.0516202,0.055860784,0.041661937,0.027189502,0.10811764,0.023765948,0.046057217,0.050133877,0.07161496,-0.028717741,0.049073458,0.100093596,-0.048681352,-0.008365214,-0.038607955,0.058668267,0.06398074,-0.09637338,0.011684426,-0.00068328023,-0.024295874,-0.037410673,0.080299556,-0.037129194,0.05016516,0.0922548,0.06370103,0.04730561,-0.044935685,0.013142821,0.06113602,0.051966388,0.06377331,-3.708048e-08,0.0431249,0.0029551636,0.0012271344,0.021558538,0.049103364,0.019172972,-0.05301003,-0.0212963,0.08026671,-0.020497208,0.00070246216,0.03539628,-0.036610547,0.010675064,-0.03976134,0.109378755,-0.042191584,-0.0020784612,-0.010402105,-0.07100072,-0.05992121,0.06061089,-0.112844035,0.023435201,0.07226538,-0.0036323788,-0.016051304,0.08898559,-0.0052910033,-0.050322905,-0.020139916,-0.01189858,-0.0073859245,-0.061954256,-0.013368607,0.025875296,0.045323595,-0.016091285,-0.044018023,-0.0041640676,-0.052676458,-0.010710502,-0.022512553,-0.026043644,-0.0032734056,0.06620658,-0.035803694,-0.0020049063,-0.019652857,-0.0030635216,0.09929804,-0.03968939,-0.037261654,-0.072116405,-0.17054828,0.026622294,-0.0418708,-0.006781152,0.03468452,-0.09358523,-0.010697529,0.042340714,0.089148045,0.010037049 +2.6.1.79,"A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC 2.6.1.78, aspartate---prephenate aminotransferase). The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate [1].",384,1.0,-0.05248326,-0.041670505,-0.06465054,-0.0137423985,0.06305924,0.101152554,-0.03943046,0.05512867,0.073646635,0.053660482,0.067061804,0.0012720833,-0.10263355,0.01887012,-0.031435348,0.024208292,-0.031215731,-0.028263502,0.016638579,-0.03799883,0.05499427,0.036254425,-0.01756229,-0.02363556,0.15118457,-0.0839151,-0.035895232,-0.054923993,0.048679486,-0.007685457,-0.08323696,-0.02068818,0.010709076,-0.035867177,0.0049846824,0.15003271,-0.047013212,-0.086078435,0.03102168,-0.029349433,0.092643246,0.008119667,-0.015170375,-0.0047094026,-0.10794349,0.023060624,0.08657115,0.040509902,0.032591686,-0.105621524,-0.046052273,-0.021311969,-0.042149797,-0.039667003,-0.06565967,0.07484999,-0.030201118,0.019962996,-0.05474346,-0.04359652,-0.09099251,-0.030946197,-0.0049730707,-0.02580006,0.022846932,-0.013245591,-0.026898824,-0.037686344,0.031249058,-0.05033906,0.020170271,-0.04222172,0.114725046,0.054094985,0.0038560717,0.019191636,-0.086601615,0.08631196,-0.03221361,-0.039147522,0.006869314,0.030219527,-0.016844984,0.005875489,0.0693249,0.03306807,-0.03424871,0.054040786,0.01665161,0.019967467,-0.0004636682,0.06978558,0.018801834,0.009595383,-0.12983203,0.069000185,0.08488023,-0.019381309,0.042110827,-0.015778005,0.028972512,0.087331764,-0.019209353,-0.0146859335,-0.052583408,0.02595448,-0.08879067,-0.009686692,0.025971442,0.016284328,0.00090713875,0.0024904364,0.06696821,-0.003724183,-0.04500479,0.045791697,-0.023368036,-0.05419243,-3.0690167e-05,-0.005672182,-0.024186838,-0.025790185,0.043336373,0.100040875,-0.03393934,0.08359979,-0.10819429,3.3623554e-33,0.038939763,0.002878123,0.019933952,0.012314426,-0.034514762,-0.016680917,-0.03424544,-0.007789062,-0.0053954837,-0.10475634,-0.10290566,-0.14180583,0.031265847,0.00070545677,-0.045012932,-0.06592369,-0.06917661,0.008151953,0.064051285,0.021021593,-0.01629485,0.002795064,-0.05141519,0.08343398,0.029351655,-0.054113474,-0.008651607,0.010776636,-0.030165704,-0.02456008,0.030635817,-0.092437655,-0.056450214,-0.05091826,-0.024686728,-0.05795503,-0.02759808,-0.11214115,-0.040263887,0.05609689,-0.033944737,0.021138836,0.034328032,0.010338099,0.05871295,-0.018172968,-0.03193269,0.043345276,-0.07179968,0.065612994,0.034052294,-0.024887942,0.10117771,-0.0034974376,-0.090770856,0.0062452136,0.030570121,-0.0038012026,0.02538146,0.07936092,0.01225978,0.0073988996,-0.034922015,0.0017201279,-0.06966224,-0.00014826511,-0.004323415,-0.06456679,0.0036223147,0.11173344,-0.082951196,-0.067834385,-0.0026446285,0.05130029,0.04720755,-0.06326103,-0.060115602,0.057687696,0.026334178,-0.021738201,-0.0014731429,0.012339921,-0.035828914,0.0118243,-0.042778347,-0.03165986,0.035608206,-0.080714196,0.047627382,0.006953525,0.09041302,-0.08223013,-0.0046083704,-0.015236556,-0.0068337773,-2.9006859e-33,0.092266835,-0.10487973,0.033959787,-0.004913833,-0.06482453,0.03040155,0.061384518,-0.060895108,0.038865246,-0.062048852,0.06850122,0.00889165,0.047249425,-0.02782734,0.0431885,0.052387584,0.030990986,0.05360046,0.06343681,0.0065963473,0.0024077755,0.08159036,-0.010101945,0.02028967,-0.0017010536,-0.00875268,-0.067469895,0.06042462,-0.0077718557,0.04258178,0.0063413996,0.051456932,-0.041245583,-0.049658515,-0.057223473,0.02703616,-0.07567702,-0.059598677,-0.0022359234,0.0445761,0.05883008,0.08375265,0.06123653,0.06562851,-0.018996106,-0.01087354,-0.049684633,-0.008605897,-0.044648066,0.024570145,0.035417862,0.010845294,0.02764756,0.0004287976,0.017345965,-0.023388222,0.020428637,0.0031214377,-0.034589663,-0.0066966983,-0.022237806,-0.068837576,0.064048804,0.047619604,0.00093547796,0.030225901,0.0031508987,0.058648206,0.007594429,0.06016488,-0.010590665,-0.010012227,0.0010778958,0.12965368,-0.027125385,-0.052864973,-0.010890994,0.078573,-0.015922213,-0.001265442,-0.12043247,0.029994689,-0.022710215,-0.049260434,0.04712165,0.0030678185,-0.002642362,0.050226048,0.037273217,0.053002376,-0.023044806,-0.016219176,0.033040967,0.042402465,0.11511613,-4.306261e-08,0.03691953,-0.01728541,0.03505727,-0.011046061,0.006153141,-0.06277126,-0.01718683,-0.03530688,0.009597429,-0.051781513,-0.03063385,0.05623329,0.011459545,-0.009995657,-0.015142853,0.06120477,-0.022993082,0.071628384,-0.048667327,0.00962644,-0.06426542,0.06664505,-0.15495074,0.042744998,0.094816715,-0.016089749,0.015837908,0.10467698,0.041444983,-0.03676081,0.054040547,-0.0023688234,0.051380098,-0.04824239,0.014455688,0.0380796,0.016435068,-0.027582262,0.03491455,0.046500016,-0.023848852,-0.061917506,-0.036925577,-0.014753982,-0.0025434748,0.06975978,-0.019083826,0.014002428,-0.015502737,0.016490981,0.08318616,-0.031704176,-0.02247059,-0.09111335,-0.06965579,0.0032818043,-0.016132852,-0.00119232,0.020940091,-0.066097945,-0.012882784,0.041721188,0.15190402,-0.036274653 +2.6.1.80,"A pyridoxal-phosphate protein. This enzyme is produced by grasses. They secrete both the nicotianamine and the transaminated product into the soil around them. Both compounds chelate iron(II) and iron(III); these chelators, called mugineic acid family phytosiderophores, are taken up by the grass, which is thereby supplied with iron.",384,0.99999994,-0.052227978,-0.034015734,-0.085947886,-0.014959493,0.11920162,0.03107893,0.05715872,-0.034161393,0.09217576,0.03671022,0.049398728,0.003842304,-0.08020562,-0.021047514,-0.050189923,0.00992216,-0.042267475,0.021914411,-0.03747651,-0.034308374,0.064522654,0.05920136,0.07288227,-0.016216554,-0.011560251,0.041446935,-0.015850028,0.01803988,0.0043186513,0.012233955,0.04281489,0.012736921,0.020668885,-0.06207343,0.008133625,0.05573031,-0.082790375,-0.029184408,0.024714418,0.03523952,0.02155488,-0.083149984,-0.018238014,-0.011017154,-0.08203008,-0.017389571,0.104482435,0.028659213,0.05022082,0.01160181,-0.039875943,0.012378163,-0.044971555,-0.0014136255,-0.07740137,0.040082995,0.023074104,0.04790194,-0.059576135,-0.017167173,0.03577322,-0.034202635,-0.067476586,-0.021714274,-0.014893685,-0.06495214,0.0283972,-0.044142075,0.066977136,-0.091198795,-0.068332404,0.0025573154,-0.013816087,-0.0048994105,-0.0648908,0.09313053,-0.056974877,0.0008323157,0.056786984,-0.035054624,0.017363252,0.027895343,0.0042486507,0.10183709,0.02577905,0.056346104,0.01788219,0.06501135,0.046929818,-0.09223648,0.0019133659,-0.03669415,-0.014827005,0.032471396,-0.08307501,0.029049048,0.06171936,-0.04669627,-0.0055182176,-0.019162113,-0.0009259805,-0.017896246,-0.00091776584,-0.10068627,-0.07878975,0.073156506,-0.14676253,0.07811861,0.029537022,0.044797517,-0.029065473,0.026740132,-0.008014528,0.03235784,0.04135357,0.11654418,0.06526335,-0.018946078,-0.053956196,0.053154487,0.0058023846,0.014154726,0.02728548,0.08506153,0.003217164,-0.020857908,-0.07366449,1.5909326e-33,0.034602806,0.059952497,0.005616064,-0.00061723124,-0.022895204,0.012502401,-0.08072742,-0.022884924,-0.02803439,0.022667391,-0.07964989,-0.08318284,0.07161279,-0.0046521495,-0.03480129,-0.060102582,-0.06426583,-0.054181803,0.13153763,0.013688708,0.010100612,0.1265631,-0.007228749,0.055780523,0.02019786,0.056224864,-0.035637137,-0.009298977,-0.018527033,-0.013531288,0.096014604,-0.10058326,-0.08819772,-0.07210132,0.07689676,-0.008274878,-0.031969342,-0.052607175,-0.028823877,0.011882895,0.0023995223,-0.03986683,0.06110685,-0.020079684,0.034080777,-0.0904345,-0.08192249,0.071754135,0.07863931,0.0366573,0.007699058,0.0013202125,0.12395684,0.008726239,-0.0974447,-0.02962169,0.024094412,-0.006459501,-0.0050385254,0.059895515,-0.0052544316,0.00054773176,-0.071866445,0.028668584,-0.036931515,-0.023191422,-0.015257413,0.0001578191,0.06497961,0.11200468,-0.021083914,0.03536798,0.022199012,0.02586667,0.00016980158,-0.034719005,-0.076041155,0.052404825,0.0024896304,0.08884851,-0.021176236,-0.06365545,-0.1110093,-0.0028513838,-0.16343437,0.0038688786,-0.039136432,-0.022636726,0.07303614,-0.0021488294,0.008988382,-0.07627811,-0.019684961,-0.004784789,0.0066999923,-2.5892335e-33,0.04338568,0.0125620505,0.029959813,0.0051132212,-0.032458015,0.019737044,0.060374517,-0.037905484,-0.026638763,0.041542985,0.0005922417,0.03391046,0.042695854,-0.025349403,0.0013287882,0.052977923,-0.0041437964,0.07612672,0.073664546,0.04399808,-0.041099407,0.047345344,-0.0037471878,0.031792425,0.08899439,0.0063542114,0.010358909,0.026349237,0.0051937033,0.05196034,0.029957937,-0.020224648,-0.0021762752,-0.10343122,-0.020665562,-0.022310138,-0.04272022,0.007396533,-0.0030323167,0.03214351,0.024959804,-0.028795367,0.0962609,0.07196666,-0.0031283477,-0.050253853,-0.093043886,0.044859704,-0.067257494,0.032363348,0.013694325,0.07318744,-0.025928644,0.013826318,0.109745264,-0.0041511725,-0.020457232,0.026663626,-0.06454908,0.0387786,-0.038467713,-0.030410355,-0.037920725,0.047953896,0.06901315,0.06946686,-0.05169651,0.04146528,0.036631953,0.07796533,0.033423584,0.0024768135,0.098435335,0.0073166024,-0.0052536433,-0.0049073864,0.002784753,0.049913622,-0.038530145,-0.01972152,0.052101888,-0.053762235,0.06293745,-0.08333011,0.023227263,-0.044184215,0.022513475,0.03849864,0.048282154,-0.0142137585,0.011626133,-0.060900558,-0.0097797755,0.043130446,0.09306171,-3.8485528e-08,-0.04712036,-0.062441103,-0.0030677095,-0.04905604,0.0147215035,-0.018469628,0.04988875,-0.02362808,-4.3080527e-05,-0.016464477,-0.021804461,0.05403071,0.038326114,0.023340285,0.05124513,0.072223544,-0.020909179,0.02867219,-0.025365297,-0.0367919,-0.089591935,-0.0102870595,-0.0814172,0.030323867,-0.017182618,-0.040056836,-0.04643478,-0.03661438,0.023416972,0.061503813,0.033850107,-0.002155949,0.00017100568,-0.061966445,-0.08141874,0.066464216,-0.030463025,-0.036583804,-0.02707325,-0.009747397,-0.08631398,0.021288186,-0.07023769,-0.030667206,0.02942717,0.009456691,-0.052720968,0.009244407,-0.029327871,-0.026020763,0.019804636,-0.00090125925,0.020703996,-0.08005494,-0.11949555,0.0093240645,-0.02984877,-0.043865815,0.03262173,-0.06529434,-0.07128255,-0.0024018567,0.15118323,-0.115491845 +2.6.3.1,Acetaldehyde can act instead of acetone; D-glucose oxime can act instead of pyruvate oxime.,384,1.0,-0.054101452,-0.025955305,-0.03836273,0.018373948,0.08155825,0.034391996,-0.03758748,-0.0033141177,0.009794468,0.0071666,-0.01587518,0.022072336,-0.14073989,0.025986465,0.04125242,0.055785876,0.0081247715,-0.015144918,0.03244946,0.020527618,0.09413722,-0.011507181,0.07228324,-0.056711767,0.09118595,-0.014666524,0.010743604,0.06871611,-0.028582357,-0.058149986,-0.000744451,0.015664117,-0.041663304,-0.034547545,0.045718398,0.06771232,-0.05546958,0.043522336,0.0003039059,-0.04451109,0.056046262,0.039753094,-0.049917385,0.047126435,-0.039513525,-0.024987107,-0.0625824,0.03454747,-0.0870005,0.004550818,-0.020431897,-0.021106713,-0.12410576,-0.015582343,0.0013636228,0.017081866,-0.0177626,0.023491506,-0.026399283,-0.078049906,-0.042390812,-0.0071278843,-0.031548046,-0.0419161,-0.0013330295,-0.096800394,0.09851682,-0.08801729,0.007044918,-0.018698059,-0.0616942,-0.039952382,0.03798497,0.04778856,0.060528774,-0.04825356,-0.050213687,-0.056393933,0.03397989,0.012113883,-0.018116567,0.051592212,0.013489434,0.004351466,0.07233932,-0.01643175,0.0013638624,-0.03429971,-0.02727207,0.0066996627,-0.06320711,-0.013817076,-0.032350786,0.041021097,-0.0058943112,-0.0377074,0.1697295,0.07072149,0.04689913,-0.02418962,0.017030392,0.10878242,-0.07596324,-0.010470806,-0.028472105,-0.008951213,0.029440595,0.023827903,-0.0034726367,0.022058785,0.007724389,0.024957309,0.05105159,0.025649467,-0.052874476,0.051109806,-0.032877676,-0.03960335,-0.039035555,0.056422953,-0.021361813,0.0107215205,0.060361743,0.054945424,-0.046469793,0.040189624,-0.029321423,3.4481007e-33,0.036738843,-0.03440619,-0.029839598,-0.03859599,0.034698565,-0.00432941,-0.14688039,0.000624748,0.09118338,0.043273766,-0.022621876,-0.057822183,0.06996244,0.023705833,-0.03095312,0.059517767,-0.08520273,-0.050292853,0.04676512,-0.04681019,0.004061526,0.0048161945,-0.003942455,0.05585497,-0.031234384,-0.029586464,-0.027858505,0.14055824,0.038213864,-0.0040604793,0.043327175,-0.09785526,-0.025226733,0.009559562,-0.04069123,0.060595643,-0.04861421,-0.036164027,0.009313182,-0.008932274,-0.0054497477,0.026258914,0.00606456,-0.03956921,-0.051416818,-0.038555853,0.017892437,0.083314076,-0.0242818,0.05623535,-0.010467252,-0.050457794,0.08701864,-0.025223594,-0.013188654,0.036649175,0.009367294,0.00088014244,0.060802646,0.010040117,0.037155665,0.02605551,0.09105314,0.023134293,-0.051989716,0.0035501611,-0.030949976,-0.020553129,-0.020525146,0.010089924,-0.03718354,-0.029984508,0.10527205,-0.013701791,-0.04321539,-0.048210733,-0.03534338,0.012223782,0.016095884,-0.054952122,0.037491564,-0.033534277,-0.0063581276,-0.06943099,-0.050143965,-0.031328052,-0.06958124,-0.01171723,0.03147635,0.0167956,-0.019740589,0.004371784,0.01643579,-0.03612721,0.034957603,-4.634818e-33,0.018693218,-0.024223652,0.025489999,-0.05147827,-0.010451142,0.059724387,0.037856393,-0.0710499,0.061977856,-0.0006058528,0.051684935,-0.01896213,-0.053160857,-0.040832024,0.0468963,0.048716668,-0.04694937,0.04437289,0.028042946,0.036581047,-0.07808622,0.084267125,-0.10570415,0.03715334,0.06504467,0.041206717,-0.048347265,-0.045320418,0.098906726,-0.003497889,0.03185395,-0.02537479,-0.01519975,-0.007616692,0.023906663,0.052861072,-0.054581176,-0.00081313914,-0.12340575,0.03552748,-0.016590387,0.050445616,0.051865827,0.06677843,0.086101495,0.047582366,-0.029140098,-0.079674944,-0.020726422,-0.019032197,0.07113253,-0.0009770598,-0.09677973,-0.043989178,0.058044653,0.13714686,0.0369031,-0.03491077,0.0019502963,-0.052602634,-0.03885885,-0.06936463,0.0137185445,-0.06440184,-0.015693733,0.050276507,-0.0068604173,0.0429401,0.10091648,0.072497375,0.06435533,0.08094171,-0.061252486,-0.0054921093,-0.016348418,-0.063823745,0.008370277,0.048688196,-0.0482528,-0.055155568,0.015201411,0.03203288,0.0032630188,-0.0588068,-0.113649234,-0.028618604,-0.063990824,0.04111531,-0.03768647,0.007982187,0.019304238,-0.052070297,0.0006914799,0.057570666,0.09804634,-2.5902862e-08,0.0393205,-0.0006045141,0.10528202,0.027032161,-0.040643718,-0.10170549,0.06816263,0.039279856,0.07966852,-0.023148643,-0.04137613,0.12732595,0.083149776,-0.0037677959,0.0062302733,-0.01812613,-0.083056256,0.06873478,-0.043466106,0.03004059,-0.099750265,0.018277148,-0.08186321,0.059727676,-0.009555027,-0.07519759,-0.005810113,0.040069643,-0.02241836,-0.01945029,0.019376665,0.0797957,0.022630852,-0.06513942,-0.08156034,-0.060094003,0.059356313,-0.037278567,-0.038967147,0.012884843,-0.00083996943,-0.1176542,-0.0947769,0.03787448,0.032455698,-0.023747945,-0.0019683999,-0.07430904,-0.027380683,0.026521357,0.066895664,0.052611403,-0.03701399,-0.04118382,-0.01437618,0.07902121,-0.043840103,-0.027654473,-0.008796032,-0.062476855,0.08156373,-0.0059172874,0.10744215,-0.062095925 +2.6.99.1,"The purine residue is transferred on to the apurinic site forming a normal glycosylic bond. dATP reacts at sites of the double-stranded depurinated DNA that lack adenine, and dGTP at sites that lack guanine.",384,1.0,-0.086913526,-0.042034812,0.007397724,-0.07741206,0.0035400551,-0.026982121,0.08188127,0.034546874,0.0018629992,0.018046917,0.08103633,0.022633662,-0.08101341,0.0163544,-0.07458066,0.0033007714,-0.064506754,-0.014759223,0.09257892,-0.011417494,0.028621873,0.032653198,-0.05517121,-0.032536972,0.029392695,0.08230515,0.021827644,0.03187193,0.062342327,-0.049936432,-0.053559687,-0.027779618,-0.06745945,0.008255828,0.02805244,0.1328293,-0.026389481,0.009983409,0.022261022,-0.0067817215,0.04782443,-0.009051405,-0.07470534,0.084498845,0.028658744,-0.0034318492,0.026504304,0.06325203,-0.08236147,-0.015945897,0.10414922,-0.0011138023,0.03017395,-0.008025033,-0.05700134,-0.0010473422,-0.04077109,0.0036287515,-0.031537693,0.024233062,-0.0581842,0.019106295,-0.0048420504,-0.032997176,0.09972411,-0.06346964,0.10903024,-0.0036213354,0.0037011437,0.0018126597,-0.017164703,-0.0046082074,-0.025807621,-0.02622812,-0.027617427,0.04512532,-0.06620411,-0.07200313,0.048090763,0.015468086,0.03172923,0.017160278,0.05344344,0.047570128,0.046855964,-0.004224908,0.0030791294,0.012656676,-0.06060983,0.017035447,0.031000342,0.021374557,-0.013768297,-0.010633497,-0.0288386,0.068319865,0.030703349,-0.018723702,0.032571226,-0.03351843,-0.037725337,0.048147537,-0.08709656,0.007738091,-0.03033124,0.011009786,0.0066276616,-0.048911467,-0.014618559,-0.0039315904,-0.073398806,0.090422586,0.004094522,0.016054623,0.0004800325,0.040032044,-0.0657967,-0.06151854,-0.02755254,-0.09424081,-0.06697428,-0.04649358,-0.06714299,0.106345214,-0.088651866,-0.019362679,0.04695086,2.4447674e-33,0.06565388,0.07365032,0.0035064835,-0.021620855,0.010049984,0.0349909,-0.09114305,-0.031281043,-0.03660874,0.02336481,-0.046091698,-0.10352033,0.0031733157,0.020981818,-0.06568401,0.016531738,-0.039244723,0.057723895,0.116741344,-0.08247999,1.7433767e-05,0.10298417,-0.020734187,-0.0057014204,0.010213789,0.07906392,-0.123924665,0.034533348,0.043731034,-0.031138286,-0.013714395,-0.05797013,-0.021087654,0.053060584,-0.0018651468,-0.03168118,-0.0097322455,-0.055345304,0.03566825,0.07316087,0.022551326,-0.022475844,-0.0029882116,0.025844028,0.0401283,0.0005206935,0.016469741,-0.03804295,-0.047741666,0.04043152,0.04652134,-0.012531184,0.0055829785,-0.07602338,-0.05922052,-0.0025775775,-0.025404513,-0.12833144,-0.03610976,0.10741835,0.08150654,0.02184422,0.0067172726,-0.07458158,0.021800818,0.042149074,-0.11686032,-0.048484396,0.10245572,0.10164427,-0.016405089,-0.043606695,0.090276286,0.017277138,0.022670535,0.018105237,-0.054228652,0.111655265,-0.0005451515,0.04068412,-0.099044606,-0.027951602,-0.054391902,0.00039390064,-0.012867981,-0.015177802,0.024708608,-0.049937952,0.048416134,0.035191085,0.12471822,0.006279412,-0.027227975,-0.07805436,0.015542281,-3.1800472e-33,0.079799406,-0.061242457,-0.0068970607,-0.018217215,-0.07964219,0.0060955994,0.048347704,-0.05121883,0.08359528,0.04389724,0.033213068,1.3024287e-05,-0.025339842,-0.03999103,0.00013413148,0.037943907,0.022446945,0.11761418,-0.08112603,0.001716324,0.04386023,0.007390324,0.016847553,0.08825384,0.034871556,0.011830537,0.0005983132,-0.07813739,0.03049482,0.0322956,-0.0019407547,0.0043764366,-0.08819925,-0.00019800561,0.053548325,-0.016430136,-0.04843811,0.032088526,-0.08410617,-0.046421908,0.018963037,0.076623,-0.024562208,0.08198609,0.058121398,0.10530649,-0.03367046,0.04891407,-0.021355944,-0.07420021,0.031831615,0.0087626735,0.009696614,-0.0431221,0.044006936,0.033467937,-0.0059974184,-0.040133726,0.0301917,0.0033876032,0.019975446,-0.039043956,-0.106655285,-0.05582297,0.043812033,-0.009812255,0.045767702,-0.0007282838,0.057188608,-0.016035229,0.009883863,0.01738214,0.05896934,-0.013702421,0.00095506985,0.023093216,-0.048877593,-0.027057666,0.058822047,-0.06355986,-0.029182842,0.029938934,-0.0486544,-0.03191395,0.035884384,0.016962316,-0.022326225,0.063271195,0.034865517,0.011689066,-0.035441075,0.045184992,-0.018895537,0.050276585,0.031108655,-3.2416377e-08,0.018034762,-0.029452195,-0.010670733,-0.08356534,-0.025076272,0.05289229,-0.037113223,0.018178862,0.10651968,-0.051688824,-0.049719747,0.0739091,0.018635225,-0.036875334,0.03069641,0.059388246,-0.003658172,-0.03753076,-0.027626047,-0.06594642,-0.15101987,0.04570402,-0.11055718,0.085634865,0.004370311,0.039179422,0.05644323,0.07836266,0.020464357,-0.019047614,0.13493335,-0.03924774,-0.020439997,7.9931146e-05,0.09868844,0.045955274,0.03810033,-0.018615419,-0.010917327,0.023565792,-0.06469539,-0.043557886,-0.0053362288,-0.007909902,-0.014538441,0.052955706,-0.009399144,0.007937861,-0.02487369,0.017581947,0.043192774,-0.07666974,-0.041005652,-0.02810834,-0.022269918,-0.086585574,0.028590772,-0.065793954,0.009453495,-0.07083056,-0.037113752,0.06478541,0.10540749,-0.047874633 +2.7.1.1,"D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.",384,1.0,-0.07345771,-0.08060416,-0.069328226,-0.041998994,0.022128478,0.009669951,0.022365954,0.0400208,-0.0011129129,0.020150423,0.0037571387,0.02107259,-0.10423437,0.09673437,-0.03359207,-0.020727484,0.01678385,-0.0071533574,0.010961453,-0.03546004,0.024017906,0.011313986,0.012322727,-0.08957816,0.10633065,-0.036409587,0.028291147,-0.028669618,-0.0069540697,-0.066092275,-0.084578484,-0.05626753,-0.0098339515,-0.015298643,0.027072517,0.06782425,-0.025704486,0.051869377,-0.045023695,-0.039159875,0.0071093575,-0.023658652,0.018492887,-0.0042573838,-0.105002806,-0.05003277,-0.06877729,0.057722107,-0.002576159,-0.024834022,0.016082572,-0.02044319,-0.01517711,0.059481356,0.03945085,0.028610932,-0.022936273,-0.043501165,-0.03584764,-0.053677768,-0.07575795,0.018011007,0.013114337,-0.03166928,0.08965694,-0.032242052,0.035844043,-0.012486502,-0.042444218,-0.03594972,-0.00538448,-0.08075221,-0.007858032,0.036136072,0.024985133,0.00045439613,-0.07985771,0.011121724,0.094085656,0.054710876,-0.018818792,0.058048155,0.09192157,0.039968252,-0.04455533,0.020724893,-0.10451196,0.10685757,-0.057611622,-0.026559416,-0.034780547,-0.073056035,0.004334151,-0.03645664,-0.025611026,-0.033093754,0.05524268,-0.010452532,0.047073275,-0.05606476,-0.004476754,0.04807068,0.026680866,-0.05103737,-0.043594625,0.018901456,-0.035403945,0.028472265,0.07611612,-0.043593206,-0.034895778,0.021906322,0.060220722,0.049255412,-0.05589985,0.028018573,-0.009017934,-0.09794804,-0.034269337,-0.03500656,-0.04316992,0.028703786,0.10075793,0.0765722,0.011902065,0.05489924,-0.017812205,2.0233597e-33,0.054670084,-0.035650685,0.015194406,-0.014785929,-0.022200175,0.036301438,-0.01814543,0.07502643,0.031108087,0.005821348,-0.13100795,-0.054052938,0.04067596,0.09903696,-0.059052203,0.038509715,-0.032128043,-0.024873888,0.07228167,-0.030306635,0.0064576883,0.09200836,-0.001924283,0.06055534,0.076995045,0.051934376,-0.10141239,0.07516568,0.08004742,0.0022516095,0.02425829,-0.07697629,8.640661e-05,0.0510544,-0.01830741,0.05068607,-0.01929316,0.0061324877,-0.025107484,0.02650275,0.04166351,-0.062756546,-0.04306076,-0.039642543,0.045649167,-0.004133727,-0.03345414,-0.07329087,-0.106853426,0.09441607,0.058654293,-0.039866436,-0.025374293,-0.086451225,-0.06038814,0.006622453,0.0069634016,0.0064917374,-0.0006316209,0.0612618,0.007205534,0.053078186,-0.009313539,0.020156248,-0.029294435,-0.004882182,-0.06140401,-0.113358036,-0.10382677,0.0718076,-0.07794206,-0.03604618,-0.0044789775,0.03682108,0.037917603,-0.08505492,0.0027620883,0.0025432564,0.01729811,-0.039589193,-0.012059762,-0.050902527,-0.054881897,0.0098502375,-0.084310494,-0.02956468,-0.043441877,-0.13480759,0.008350006,-0.0075177657,-0.07557653,-0.008489452,-0.1047653,0.028327325,0.06921632,-5.063212e-33,0.078290015,-0.10277258,0.052518513,-0.0027876317,0.047128424,0.057954617,0.069310695,-0.08730762,0.1582126,-0.014338667,0.056409527,-0.014079057,-0.021754107,0.0022721349,0.023866003,0.014609124,-0.072210304,0.06032679,-0.033725463,0.011514888,-0.07015118,0.104475014,0.04233075,-0.024073701,0.046080854,0.028817328,-0.009782543,0.0012841368,0.06924424,0.063277505,0.033396795,0.037322387,-0.02033163,-0.04158088,-0.0009485353,0.02586782,-0.04300984,0.025343983,-0.07458646,-0.0345739,-0.020282513,0.050382335,0.022835119,0.09294285,0.037901696,0.00423828,-0.059510674,-0.007600187,0.021638274,-0.030056579,-0.01106917,0.024721043,0.01990194,0.03707964,0.018418556,0.101355046,0.09863074,-0.015153185,0.012136639,-0.03618841,-0.07642228,-0.023647288,0.06772148,0.018225346,0.06137183,-0.023290705,0.011466673,0.023179345,0.02382967,0.031222338,0.09443242,-0.096848786,-0.0111751575,0.07717002,0.0022805321,-0.058675166,-0.08980201,0.04105966,0.03200736,-0.066705145,-0.03771921,0.025485305,0.06120141,0.006132196,0.036723714,-0.080024876,-0.0025828064,0.03994516,0.025987664,0.052704375,-0.018496457,0.022832882,-0.024450637,0.03589801,0.06091374,-3.7773983e-08,0.07407888,0.00056295516,-0.03241225,-0.017529326,-0.033823717,-0.0279072,-0.015058753,0.022428889,0.024857813,0.02693181,-0.0125038,0.17995295,-0.050504383,-0.030457146,0.069899596,-0.007973156,-0.05839756,-0.005830056,-0.036122303,-0.013704131,-0.13284358,-0.03405211,-0.033667684,-0.00085717207,-0.0037713922,-0.040128972,0.021983558,0.05522885,0.047302626,0.054853696,3.0101704e-05,0.06459684,-0.029461458,-0.04769664,0.00401242,0.01479561,0.02433461,-0.06293893,0.0014907826,0.014157173,-0.0105098775,-0.026719151,-0.04736314,-0.020403514,-0.0007475518,-0.00050211593,0.039393906,-0.012645546,0.0093234265,0.034044545,-0.03740372,-0.026276926,-0.043355387,-0.0440977,-0.043187667,0.03040974,-0.03192724,-0.037837893,0.049944904,-0.069942415,0.020176645,0.05307226,0.16809958,-0.050052274 +2.7.1.2,A group of enzymes found in invertebrates and microorganisms that are highly specific for glucose.,384,1.0,-0.04292635,-0.020794457,-0.114697844,-0.002392201,0.027442828,0.024969824,-0.026408955,0.009282503,0.045979645,0.03350763,0.010913752,-0.06810897,-0.08235166,0.06410303,-0.04994774,0.04029771,-0.04203466,-0.030192507,0.05930421,-0.05554209,0.08455659,0.07664095,0.030691702,-0.03072768,0.04457222,-0.038154505,0.04409238,-0.07040955,-0.063866824,-0.019642988,-0.029952113,-0.00026561224,0.109547436,0.003060903,0.0597152,0.16440646,-0.047664896,-0.09149329,0.012979963,-0.037705008,0.020856353,4.78397e-05,-0.0031924844,-0.010277132,-0.054991886,-0.03513025,-0.0044726697,-0.017214768,0.039750315,-0.014486772,-0.08631957,-0.07024659,-0.068824984,0.043684416,0.055095255,0.0068505276,-0.028400125,-0.043118898,-0.06448061,-0.10887951,0.043512553,-0.010677705,0.059186008,0.01864641,-0.024485268,-0.038423765,0.044832043,-0.030684983,-0.018555561,-0.058109075,-0.09687812,-0.08225847,-0.021590034,0.03281311,-0.02007064,-0.03556368,-0.03963947,0.00990035,0.012140879,-0.030024985,0.02007095,-0.020252677,0.07098772,0.04297949,0.025475243,-0.05152956,0.10374367,0.04976187,0.021641344,-0.03164781,0.005997209,-0.030133942,0.0068312003,-0.033265192,-0.019107472,-0.005626459,0.035822626,-0.029053435,0.08730774,-0.04254202,0.012482427,-0.009029905,0.07969201,-0.024507629,-0.07152729,0.013279368,0.011665102,0.069304384,0.09468471,0.0057857516,-0.012520191,0.06643451,0.057186842,0.0304588,-0.061874256,0.007349158,0.0025685003,-0.050505012,0.022734802,0.0762153,-0.017504502,0.0047625294,0.08355062,-0.015915891,0.036318656,0.138507,-0.13719758,-4.4856064e-33,0.09417579,-0.05875677,-0.039993625,-0.061741177,0.022991043,-0.001425169,-0.023166312,0.069905005,-0.0040771775,0.016595334,-0.08723041,-0.044835895,0.037252404,0.056448888,0.03489501,0.04069973,-0.012463212,-0.018506909,0.09928842,0.015723115,-0.078025505,0.07135308,-0.009933734,-0.010102083,0.010456798,0.089954875,-0.015522336,0.0033765137,0.03610484,-0.002111101,0.09594218,-0.10688634,-0.037686247,0.051152267,0.09519756,0.08571826,-0.021086074,0.017492143,-0.01806734,0.007629979,0.045672562,-0.011887879,0.056242347,-0.09723216,0.06795376,7.1134884e-05,-0.07880741,0.059009105,0.047801036,0.049462866,0.011258899,-0.03393835,0.071080334,0.012763947,-0.04138693,0.070330225,-0.053821314,0.040849015,-0.026729148,-0.0059343576,-0.051025696,0.080202356,-0.04286669,0.014777296,0.027310513,0.02492588,-0.06053413,-0.010001484,-0.06750256,0.073176414,-0.05174311,-0.04216911,0.029384524,0.0048409696,-0.018330975,-0.032303035,-0.01691753,-0.042761363,-0.045053247,-0.015215101,-0.0062442506,-0.05184838,0.0075465725,-0.078872755,-0.09720194,0.025896998,-0.017976085,-0.072291985,-0.027840232,0.022431297,-0.059824344,0.0055659595,-0.1009781,0.0031064444,-0.005138318,-2.4562453e-34,0.10437127,-0.113231994,0.049618296,-0.074895956,0.0014726665,0.0628832,0.0057042222,-0.100093335,-0.011897471,0.00071218284,0.00018613465,0.09556439,0.019842826,-0.10345381,0.050982658,0.042477626,-0.052328706,0.05800535,0.046221897,-0.028680135,-0.014531212,0.11449926,-0.007275213,0.015983684,0.06576384,0.0044841976,0.018134134,0.09007518,0.012025396,-0.029638814,-0.022632143,-0.0030848102,0.0048877825,-0.037330627,-0.034494173,-2.7322565e-05,-0.03927882,-0.045102645,0.0040779216,0.023279313,0.029660044,0.0642884,0.0153052155,0.026187845,0.07366708,0.032761835,-0.059044745,0.022868322,-0.049256653,-0.044054925,-0.048419908,-0.017107792,-0.014017466,-0.06072142,0.031717125,0.07126464,-0.0439253,0.041082352,-4.0360424e-05,-0.06541089,-0.014180862,-0.05456619,0.07502181,0.066219755,0.0089362,0.040882953,0.003745737,-0.030135302,0.036491014,0.067952566,0.030078802,-0.056822278,-0.044328768,0.034287017,-0.049501136,0.005712152,-0.069506146,-0.011125002,0.026793132,-0.039489746,0.04986188,0.041954923,0.03837338,-0.07020716,-0.03450575,-0.09559983,-0.010573504,0.083166964,0.034158908,0.011247524,-0.025907826,-0.0031901565,-0.03563349,-0.029706841,0.022193087,-2.523597e-08,0.10070777,-0.027610328,0.028092127,-0.008085111,0.017036987,-0.015570521,0.0020082472,0.026032051,0.040749755,-0.0047231317,-0.008891105,0.0646935,-0.04486659,0.02069366,0.057885226,0.0020112125,-0.068785764,-0.015828948,-0.062908575,0.05729557,-0.09410471,-0.00471685,-0.09868624,0.070690215,0.0038184226,-0.08590348,0.0019143386,-0.024751054,-0.028078247,0.009388224,-0.05479849,0.1061525,0.0699646,-0.06393882,-0.09026269,-0.017154666,-0.024643412,-0.057752166,-0.0010692433,0.027005026,0.043167304,-0.074414335,-0.011293544,-0.028345881,-0.04584796,0.012038621,0.029277518,0.0035908278,0.008981287,0.018927418,-0.011393226,0.043670963,-0.072189435,-0.021362694,-0.08231493,0.009264228,-0.052132398,-0.04775553,-0.026617713,-0.06865829,0.055926308,0.025231251,0.15293252,-0.06606472 +2.7.1.3,"D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [4].",384,0.99999994,0.013963415,-0.07691528,-0.04777345,-0.027249722,0.038757153,0.051076334,0.017179023,0.0016003388,0.008173189,0.034862928,-0.021787304,-0.032466125,-0.16939025,0.05395361,-0.0031627,-0.0031061089,0.04285299,0.038252108,-0.019207451,0.02019623,0.090009995,-0.09147004,0.042376887,0.013602702,0.044551652,0.032962963,0.03826229,-0.038316242,-0.029551767,-0.13563795,0.016289935,-0.002386606,0.006291792,-0.038167354,0.034111567,0.042732384,0.032388937,0.0010319782,0.03324965,-0.0021539044,0.02129903,-0.0557719,0.025753692,0.048026957,-0.061828278,-0.04283338,-0.089277,0.07499611,-0.012507714,-0.047874648,0.030117072,-0.06548357,0.020588668,0.015953017,0.059928294,0.056068018,-0.037762344,-0.0023148423,-0.004141553,0.06627977,0.029280357,0.02695045,0.04555152,-0.004158446,0.021777796,0.024165228,-0.045061994,-0.02906337,-0.003616991,0.026970446,-0.014751738,-0.072816536,-0.010186365,-0.002130094,0.042578906,0.0042290026,-0.04745208,-0.041101474,0.055073738,-0.008543992,0.038848918,0.04856032,0.0665944,0.012504621,-0.047559153,-0.07031637,-0.007272875,-0.023225825,-0.0038678194,-0.044327307,-0.0038026418,-0.058698233,-0.025528194,-0.012842703,-0.08013934,0.01761003,0.010340877,0.04859564,0.060771197,-0.047975294,0.024325605,0.042815622,-0.06610295,-0.020703169,-0.07374481,0.020579547,-0.027768187,0.080477886,-0.00891261,-0.04368344,0.003937797,-0.03388216,-0.008494827,0.03006872,-0.072623886,-0.040851675,0.053503774,-0.0929715,-0.0007454622,-0.052910842,-0.015416103,0.065745994,0.0876646,0.05964073,-0.007129721,0.08127178,-0.07025663,-1.023836e-33,0.08083119,-0.0014777827,0.037716415,-0.035359938,-0.029659608,-0.07190784,-0.062775195,0.0052372995,-0.002129628,0.0005927588,-0.053294085,-0.030637473,0.08360326,0.021680936,0.04708126,-0.0029610074,-0.025690816,-0.041354045,0.07403648,0.013550116,-0.03856086,0.06304144,-0.049302995,0.005444918,0.006460918,0.10052623,-0.084653005,0.028486773,0.07988538,0.0008295238,0.02664982,-0.00014594254,-0.03998961,0.044924457,0.028047506,0.029221408,-0.09502063,0.043852653,-0.036425915,0.010546755,0.0014221121,-0.049112756,0.016576817,-0.083380505,0.012809539,0.008934879,-0.033077322,0.057156105,0.01291822,0.048585847,0.04097793,-0.046122603,-0.019727493,-0.008447159,-0.05672474,0.046608415,-0.0272262,-0.025553541,0.05977401,0.0339209,-0.087098375,0.04544359,-0.026044391,-0.01935596,0.014676595,-0.0001445016,-0.013954872,-0.035787072,-0.07849634,0.017541638,-0.06256506,-0.0057467283,0.06049701,-0.019025952,0.03940502,-0.0017889692,-0.07757593,-0.010720775,-0.01674173,0.037034012,0.027014712,-0.073254384,-0.070039034,-0.05419099,-0.06903477,-0.03118415,-0.091512896,-0.08561016,0.05535133,0.089069076,-0.08072367,-0.057236385,-0.026964009,-0.0053599216,0.016215596,-2.4679814e-33,0.09056447,-0.06358272,-0.004582961,-0.0125014745,-0.023723578,0.034657676,0.060946085,-0.034727197,0.014490123,-0.007195573,0.04373971,0.014813649,-0.07166817,0.011986649,-0.0027357277,0.061486967,-0.08958344,0.068471946,0.052569423,-0.04469946,0.008984148,0.07621086,-0.083850406,0.11231121,0.1408916,0.02630608,0.074460916,-0.0070882486,0.09560804,-0.0049548266,0.030666342,-0.038744897,0.07528115,-0.02419334,-0.0036724485,0.015506512,0.0064601493,0.04486677,-0.049412128,0.01498798,-0.09910395,0.07260708,0.050676733,0.052363895,0.04505139,0.04312319,-0.07872275,0.0077778376,0.037649248,0.025174616,-0.0008629886,-0.06909611,-0.09506258,-0.057443492,-0.05416003,0.06776285,0.054864306,0.003457916,-0.009425814,-0.01205798,-0.028139027,-0.073887944,0.118795194,-0.08970081,0.04979847,-0.000343683,-0.08379885,0.062923506,-0.0374323,0.0012970275,0.024193084,-0.049846187,-0.02243594,0.04214577,0.01631627,-0.10234374,-0.053128347,0.011653826,0.022198075,0.03878061,-0.018337151,0.011566136,-0.037784673,-0.002513244,0.05461214,-0.07658906,0.039927017,0.026052676,-0.031357996,0.05381077,-0.011773743,0.022330806,-0.02302821,0.091896795,0.063041225,-3.0243953e-08,0.08777891,-0.040401354,-0.033092096,-0.048618507,0.014866106,0.001176264,0.059380617,0.031926233,-0.0040454026,-0.058965083,-0.03938684,0.16194884,0.003251808,0.053496387,0.06950224,-0.031137288,-0.064029664,-0.072898485,-0.029231962,0.010224088,-0.03982438,-0.028113823,-0.09707703,-0.003358031,-0.02151119,-0.055161472,0.11725608,0.019636111,0.035113104,0.04046105,0.04262685,0.08866612,-0.022602709,-0.02454544,0.042345166,0.006567559,-0.052903086,-0.09456054,-0.047305856,0.071521774,-0.054761365,-0.05690824,-0.019141845,0.0056294086,0.0009683352,-0.060858157,-0.049340487,0.058215544,-0.010511849,0.080248855,-0.07137024,-0.0229009,-0.06926751,0.0059062187,-0.038794547,0.03536511,0.0019066739,-0.070683844,-0.009271212,-0.05129724,0.09474595,-0.012277938,0.19217145,-0.006706247 +2.7.1.6,Part of the Leloir pathway for galactose metabolism. The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-alpha-D-galactosamine [4-6].,384,1.0,0.004403968,-0.07252672,-0.081440896,0.018706907,0.046762124,0.01792475,-0.057521585,-0.00433742,-0.00078394305,0.032813538,-0.040986188,0.01844911,-0.049432695,0.057534635,-0.03728563,0.017962892,-0.04973108,0.015764115,0.015100547,0.012801605,0.16532686,-0.02061363,-0.0012674116,0.0050260234,0.048371937,-0.04589625,0.0695696,-0.08909817,-0.082991995,-0.072155,6.455078e-05,-0.075962275,0.08983354,-0.03061834,0.029925143,0.030724593,0.05198374,-0.020752583,0.027264586,-0.022231633,-0.03344994,-0.02016439,-0.015743792,-0.0008634837,-0.021097437,-0.04673975,-0.07074952,-0.011730197,0.05323747,-0.0073310505,-0.025982257,-0.021690635,-0.05710462,0.049905095,0.04966328,0.07081846,-0.042113196,-0.13815674,0.07144496,0.008726686,0.052961063,0.04212183,0.017865757,-0.011625297,-0.01611166,-0.09632187,0.057563573,-0.012229028,-0.028051035,-0.010979438,-0.0371965,-0.07851819,-0.0038340276,-0.012604658,-0.015332919,-0.011367597,0.019666558,0.0002923786,0.070366815,-0.03673323,0.027792275,-0.025435885,0.013213252,0.062073175,-0.0032566052,-0.0040863263,0.038033087,0.020241637,0.0436207,0.03573034,-0.011493859,-0.09330057,0.00023774122,-0.107440576,0.00397701,-0.0036779384,0.030730853,-0.042646986,0.073233575,-0.041327816,0.013717024,-0.016496817,0.045743175,-0.027447194,-0.04634403,0.088676706,0.03450764,0.1551024,0.04274344,-0.0021492236,0.016584862,-0.0014777231,0.0109855225,0.08592585,-0.045675594,0.058010776,-0.010533962,-0.08390473,-0.06572497,-0.00013948964,0.004613534,-0.018096771,0.08700705,0.051482413,-0.014254117,0.08430735,-0.033825833,2.6901957e-34,0.10814461,0.019770661,0.040715862,-0.07682564,0.010988991,0.035450973,-0.07556956,-0.009891038,0.017865542,-0.01741798,-0.06435315,-0.05132605,0.051539425,0.045960534,-0.031644147,0.09214107,0.0139463125,-0.06011508,0.07944747,-0.015098646,-0.0386978,-0.0011291361,-0.026215384,-0.037819166,0.036594473,0.043493297,-0.019645667,0.013272872,0.03354355,0.03222646,-0.010161602,-0.061894204,-0.019529503,0.076711945,0.07700415,0.025249692,-0.0053009205,-0.030903189,-0.029307261,-0.010112217,0.063668646,0.013976454,0.0050987415,-0.053465426,-0.009360816,-0.0007959726,-0.027897984,0.09077601,0.0034569548,0.08225058,-0.008902963,-0.053267512,0.011988779,-0.041329302,-0.023746232,0.05456605,-0.0800794,-0.009445444,0.05047139,-0.0068749804,0.052032527,0.046097554,-0.052206226,0.06369392,0.05339462,0.02411565,-0.043048512,-0.037468027,-0.022290653,0.02148965,-0.120545246,-0.06555192,0.052600358,0.008259432,0.013164784,-0.0271156,-0.04519654,0.039420493,0.044175286,0.023912081,0.05352819,0.009431428,-0.007207532,-0.037090328,0.024510628,0.041161276,-0.049448468,-0.092227355,-0.0013812513,0.0400725,0.028662657,-0.08728495,-0.046471484,0.0840361,0.0040450073,-2.023658e-33,0.09932839,-0.099161446,0.11350568,-0.033035018,-0.05259322,0.11465113,0.03677734,-0.055701572,0.06772003,-0.045841236,0.062215682,0.016832203,-0.010201307,-0.09837685,0.08210891,-0.01701151,0.04510351,0.047448363,-0.041692633,0.032884788,0.003830909,0.028129755,-0.059558406,-0.0268569,0.06169334,-0.0056600804,0.031034177,0.050383195,-0.009343052,-0.0019420991,0.03483771,0.012437018,-0.02324727,-0.13665766,-0.027073404,-0.037158012,-0.064409934,0.040266775,-0.024429092,-0.028397443,-0.029288415,0.077804096,0.0014331753,0.024697322,0.02907887,0.03756159,-0.058985755,0.0107813,0.06680596,-0.021688152,0.022489997,-0.0974121,-0.039194845,0.012276702,0.045888472,0.048585042,0.030406132,0.05615634,0.03204611,-0.05667013,-0.034930162,-0.01683205,0.059275184,-0.06152108,0.061767783,0.019665344,-0.028446665,0.05448949,-0.0026595057,-0.031298835,0.029729621,-0.043314908,0.026838107,0.060224645,0.0009513177,0.00019552876,-0.15573272,-0.13349845,-0.026415529,0.023450445,0.030950822,0.07222685,-0.044497207,-0.092378385,-0.03212528,-0.041655425,0.05824002,0.15094656,0.045219243,0.0066224467,-0.07459084,-0.04243815,-0.027507814,0.0074931285,0.06831169,-3.136352e-08,0.04591835,0.032463845,0.011084124,-0.059716694,-0.020531712,0.032028943,0.008128736,0.037580863,0.05171368,-0.02965416,-0.029070728,0.13810197,0.01684933,0.012251485,-0.0143343825,0.0050505297,0.051092274,-0.01893426,-0.00013724588,0.008770459,-0.068995185,-0.052298084,-0.05468679,0.013116028,-0.00043735487,-0.11796804,0.04829246,0.06081495,0.015763402,-0.105305515,-0.024236107,0.040825643,0.01873747,-0.058597166,-0.07104252,0.01650817,0.010388006,-0.04353781,0.061031878,0.002714136,0.06881384,-0.006229352,0.020195898,-0.0016863294,-0.05469792,0.01991142,-0.02872969,0.02942165,-0.09815285,0.0038821995,-0.050846193,-0.043702725,-0.0945962,-0.05227694,0.007630108,-0.044289522,0.03035018,-0.11161931,0.019151798,-0.046912678,0.048764806,-0.021994531,0.10019699,-0.024465017 +2.7.1.8,"The enzyme is specific for glucosamine and has only a minor activity with D-glucose. Two unrelated enzymes with this activity have been described. One type was studied in the bacterium Vibrio cholerae, where it participates in a chitin degradation pathway. The other type has been described from actinobacteria, where it is involved in the incorporation of environmental glucosamine into antibiotic biosynthesis pathways. cf. EC 2.7.1.147, ADP-specific glucose/glucosamine kinase.",384,1.0,-0.08175515,-0.08466649,-0.07813175,-0.03915696,0.03233814,-0.010369339,0.0052199,0.07354728,0.023023821,0.08766551,-0.01300547,0.028196393,8.994727e-05,0.09614509,-0.08702564,0.0397709,-0.06859461,-0.079002924,0.033878267,0.06322818,0.097027086,0.051703397,0.0080455365,-0.026227396,0.025259262,-0.00380325,0.07410939,0.009205793,-0.04086949,0.011789479,-0.05969245,0.016993653,0.021368587,-0.002824563,0.055924617,0.15333112,-0.034678176,-0.052293602,0.101936564,-0.020089159,-0.029784048,-0.0060258633,0.020498207,-0.03039298,-0.0042574373,-0.019297238,-0.021000158,0.049324542,0.0220724,-0.020296784,0.021688892,0.013374438,0.044502936,0.012365936,0.07330584,0.017562514,-0.078113,-0.051884465,-0.05851529,0.03960741,0.007988936,0.04477404,-0.022657575,-0.05185634,-0.05504972,-0.043787286,0.063823305,-0.06953388,-0.0035635547,-0.01564317,-0.10507537,-0.05067413,0.010290202,0.038866833,-0.010875444,-0.018644439,-0.03802862,0.011413226,-0.004720589,-0.10561284,0.031578112,-0.042667,0.07462033,0.110176064,-0.018305706,-0.025247645,0.037073053,0.019215494,0.064762905,0.007047467,-0.0041621216,-0.06843196,-0.01648468,-0.07930977,-0.03328051,-0.053788774,0.010556979,-0.03000653,0.05222354,-0.037662916,-0.027784219,-0.012303367,0.012997981,-0.03162768,0.013440552,0.0010983871,0.054411598,0.10121928,0.05969339,-0.041005567,-0.032192484,0.10183249,0.004077221,0.023927897,-0.105404705,0.10399596,0.010012824,-0.095628455,-0.09339649,0.06401349,0.022210857,-0.014610234,0.015738957,0.057673473,-0.011551931,0.016294155,0.00011476886,8.26016e-34,0.012480526,-0.039327487,0.0015746456,-0.13454743,0.032575503,0.05506877,-0.0464346,-0.026016863,0.07343615,-0.026483627,-0.09882578,-0.049829423,0.04216126,0.09268489,-0.019895451,0.092457294,-0.0060612387,-0.06287562,0.0787686,0.0075915228,0.06411369,0.11739359,-0.021717973,0.0036620735,0.006814761,0.076809786,-0.005225583,0.050390173,0.028829265,-0.017285025,0.0063708383,-0.036769964,-0.029433958,0.012141424,0.055395856,0.052982315,-0.097312465,0.0160216,0.041810393,0.08494,0.066718444,0.012490449,-0.042979352,-0.040193856,0.022393987,0.02368702,0.008422232,0.052481584,-0.010121397,0.06919207,0.06319477,-0.03385487,0.014569148,-0.02962743,-0.06429062,0.043020144,0.011670905,-0.07274098,0.07295253,0.03415564,0.007921275,-0.017069126,-0.049381368,-0.020794358,-0.007780517,-0.02127465,-0.03323238,-0.10843133,-0.026216868,0.041107655,-0.06547751,-0.04463934,0.02834557,0.046195336,-0.014652124,-0.05476889,-0.088277124,0.01695346,0.02788232,0.02783449,-0.014623395,-0.022801543,-0.012255172,-0.0141514875,-0.08513106,0.02047469,-0.021475563,-0.12733987,-0.0041966336,0.009363689,-0.069173835,-0.050178185,-0.09178485,0.009949281,0.008681382,-4.3465582e-33,0.058751177,-0.0051816613,0.087716274,-0.04734732,0.0021097187,0.09091503,0.023812732,-0.03509573,0.015504033,-0.0038172177,0.043311875,0.05078695,-0.020942453,0.007529276,-0.013185074,0.058621544,-0.08922452,0.080652,-0.042412724,0.011750483,-0.02088002,0.07728626,0.014176968,-0.037507385,0.08264854,-0.022074522,0.010764904,0.08381704,-0.0096022235,-0.0014298216,-0.012043604,0.017504435,-0.012969918,-0.06723478,0.004012302,0.016196776,-0.039108466,-0.02573375,-0.027698964,-0.07727042,0.052763958,0.054322872,0.07354047,0.02583293,0.020375716,0.055292394,-0.092151746,-0.047912244,-0.09279128,-0.051569805,0.027528139,0.022511836,0.013876567,-0.05296317,0.05315294,0.045931004,0.0034838559,0.025236055,-0.03637925,0.03347852,-0.0299944,0.025791315,0.081794664,0.051085267,0.06992963,0.02078186,0.02264524,0.08121222,0.02675783,0.01951241,0.014330449,-0.012264305,0.041686766,0.054398812,-0.028794618,-0.02989736,-0.11831308,-0.021230707,0.006791013,-0.051575042,0.028089324,-0.012171466,-0.030825531,-0.025449172,-0.108970955,-0.017963672,0.019662576,0.063128464,0.0026207138,0.040565703,-0.01852586,-0.02780455,-0.05894739,0.0036795733,0.07181975,-4.1338378e-08,0.045776695,-0.038649663,0.01186979,-0.024549002,0.021200942,-0.006753214,-0.011365996,0.100186415,0.06356151,-0.0006224488,-0.0072176177,0.09981199,-0.028075326,-0.025980571,-0.07797929,0.01154255,-0.06443498,-0.010371717,-0.034570202,0.028766848,-0.065105736,-0.026198829,-0.08691268,0.045858942,0.047337648,-0.09796047,-0.034092557,0.031261448,-0.07627633,-0.047316857,-0.024204355,0.08321618,-0.054934856,-0.08005936,-0.090583935,-0.030265652,-0.04784059,-0.074739754,0.019307833,0.02715299,0.04331874,0.03958232,-0.026655054,0.0079455115,0.0590194,0.0027185355,-0.01613277,-0.052191585,0.054534845,0.0049606324,0.032629974,0.036182787,-0.061211042,-0.06646373,-0.10103614,0.005885253,-0.07690907,-0.056520782,-0.009059445,-0.07539214,-0.028301671,-0.031751778,0.15010703,-0.018426342 +2.7.1.11,"The enzyme from rabbit muscle displays absolute stereoselectivity for the beta-anomer of D-fructofuranose 6-phosphate [9-11]. D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 2.7.1.105 6-phosphofructo-2-kinase.",384,0.99999994,-0.07164698,-0.0812287,-0.005289298,-0.045336057,-0.016086264,-0.0073188487,-0.00043905346,0.08865465,0.02490152,0.08993723,-0.016293274,0.029198283,-0.08846356,0.104219444,-0.040836636,0.019057805,-0.03946903,0.06403895,-0.0012493614,0.009875689,0.015573243,-0.009541913,0.027907515,-0.007953748,0.058665205,-0.037853073,0.01027288,0.045634996,-0.07820529,-0.09669122,-0.07012915,-0.047695372,-0.02802216,0.026480304,0.0049632294,0.10298065,0.0001400515,-0.07882995,-0.023138706,-0.019325295,0.056972094,-0.07798561,0.034547012,-0.016925076,-0.0037799284,0.049381264,-0.019612996,0.05223671,0.07395087,-0.005894131,-0.07309443,-0.037439596,-0.03676368,0.03692009,-0.072543554,0.105272174,-0.038836595,-0.017938577,-0.0014197439,0.034564972,-0.034462217,0.0063494826,0.06369395,0.057525065,0.04639317,-0.019030455,0.0050592045,-0.04225661,-0.06596235,0.009735341,0.026860561,-0.06872029,0.08667256,-0.050401587,0.08400731,0.050403986,-0.0982279,0.029069366,0.005271252,-0.028969666,0.04172699,-0.004903508,0.057390608,0.014774004,-0.010117365,-0.010934756,0.023543255,0.0071205106,-0.011633115,0.10194707,0.017981973,-0.01033947,-0.002611985,-0.07677179,-0.06334947,-0.027091784,0.010357553,0.05329266,-0.0050852746,-0.0011754384,-0.0064790547,0.0149695985,0.05347988,-0.02614612,0.0037057768,-0.023234323,-0.07022896,-0.020288646,0.058564898,-0.06279502,-0.014911061,-0.00085904804,0.043240428,0.097652316,0.057379212,0.080388784,-0.073787436,-0.12612624,0.0363952,-0.009644637,0.036084283,-0.08314962,0.02984865,0.060822267,-0.067054905,0.08592979,-0.12335866,2.637814e-33,0.053931087,0.034534276,0.038149484,-0.058024358,-0.08698674,0.005659028,-0.09155314,-0.0131008215,-0.082711,-0.053437952,-0.10516584,-0.057174575,0.1009379,0.043230213,-0.023858108,0.010208091,-0.02213783,0.06815031,0.049349204,-0.057986993,0.0910557,0.04904678,-0.05880876,0.014756733,0.0625494,0.069480166,-0.14280474,0.0767831,0.048230432,0.018025946,-0.0022885748,-0.046617746,-0.03147402,0.02535668,0.020192336,-0.02866876,-0.02938611,-0.028863197,0.025822338,0.011379749,0.05947613,-0.05862298,-0.057403877,-0.00132355,0.06466377,-0.03652512,0.013522365,-0.044128194,-0.036456026,0.05025334,0.020085888,-0.03714247,0.043983992,-0.037354942,-0.020071283,-0.015490517,-0.04779096,-0.01672236,0.01798892,0.017922135,-0.028235942,-0.009681195,-0.0064761336,-0.059090745,-0.029386533,-0.039567854,-0.023326632,-0.076751165,-0.09692181,0.07074795,0.0024189327,-0.05326528,0.06549648,-0.0036627788,0.0132808965,-0.031303998,0.005990013,0.029418578,-0.029285412,0.022642678,0.0010974043,0.004813159,-0.07964614,-0.0029275052,-0.036573745,-0.022770297,0.083144456,-0.109162085,0.047675207,0.034002967,0.063752286,-0.04017179,-0.11503795,0.018889476,0.082044914,-3.3254166e-33,0.104425326,-0.022027705,0.09264502,0.03331061,-0.03828682,0.06657701,0.10056123,-0.01020357,0.10657394,-0.05034727,0.049946796,-0.041086365,0.037018936,-0.103550844,0.0684911,0.020387284,-0.047564674,0.068795964,0.026028514,0.03512958,-0.010904906,0.044428553,-0.004231777,0.0722916,0.052510776,0.03599323,-0.05510415,-0.005278737,0.06846804,-0.008414073,-0.03788722,0.02071273,-0.05016987,-0.072118096,-0.013473954,0.01780835,-0.10522975,0.041479204,-0.004718423,0.014501478,0.051535856,0.042135444,0.0010620638,0.06013323,0.024991719,-0.03410199,0.0438081,0.035905205,0.0066463803,-0.04772902,0.014487808,-0.016518071,0.019881181,-0.006284726,-0.00022717768,0.08629822,0.08018579,0.048391633,-0.041904416,-0.011241286,-0.044579476,-0.07991231,0.08304398,0.0064885765,0.061167322,0.007445868,0.0051666633,0.028290669,0.007814482,0.06527907,0.05384313,0.006358224,0.00042197187,0.035858836,0.016736964,-0.008156834,-0.12518488,0.021172449,-0.010563836,-0.008575397,-0.06007054,0.07658695,0.011570598,-0.001313594,0.007977151,0.015378364,0.06692172,0.08633439,-0.058620594,-0.035447076,0.03698426,-0.059953555,-0.044209942,0.11257855,0.09842383,-4.408253e-08,0.081227005,-0.05550327,0.016819619,-0.07043954,0.037296154,-0.039411504,0.04724126,0.044971887,-0.05173961,0.013451742,-0.009922265,0.078397796,0.030666871,-0.008273156,0.054484062,0.036456518,-0.0054594344,0.017965827,-0.05749721,0.0045511457,-0.050746217,-0.048335567,-0.035709,0.028243296,-0.025805071,0.017441439,-0.0056554256,0.060668338,-0.020957123,-0.0065432717,0.0019611458,-0.03226229,-0.0682834,-0.07082967,-0.009250152,0.00039244324,-0.010873119,-0.09060389,-0.06859972,0.040029638,0.0062401188,-0.028844217,-0.0183832,0.041059762,-0.042439196,0.02383797,0.048852403,-0.0640177,-0.028878706,-0.034066893,-0.021641431,-0.004323762,-0.10391574,-0.07928531,-0.079474516,0.053906415,-0.0077525466,-0.028919056,-0.024172125,-0.037590083,0.029834,-0.018483829,0.11329186,-0.055204794 +2.7.1.15,2-Deoxy-D-ribose can also act as acceptor.,384,1.0000001,-0.010734279,-0.08651938,0.00035134895,0.02883999,-0.0042968746,-0.060869675,0.00319618,-0.012530721,0.03519573,0.064514555,0.043544386,0.007109923,-0.05879481,0.07191389,-0.0016017983,0.043509364,-0.035192564,0.026409406,0.008012165,0.10420461,0.054222826,0.059028264,0.00076368445,-0.037728183,0.010448332,-0.015047998,-0.0014879592,0.015948208,-0.0138416365,-0.106390506,0.032276854,-0.019082088,-0.009651041,0.034702435,0.0005038297,0.011957557,-0.011555361,0.011717295,-0.004904099,0.024022412,-0.020668885,0.0074614706,0.030055104,0.007284439,-0.042932298,-0.015884705,-0.065162435,0.04833144,0.036120728,-0.06523413,0.019777335,-0.0054417397,-0.08310246,0.016884334,0.027093453,0.10470605,-0.05414171,-0.01523013,-0.04303856,-0.03490935,0.02194113,-0.015385476,-0.041419405,0.01885605,0.06681383,-0.056117307,0.0038048974,0.015417222,-0.059485175,0.0067755347,0.040792815,-0.04097576,-0.03320212,-0.04474777,0.06497944,-0.0048848796,-0.00010204703,-0.07078449,0.061381824,0.04391247,-0.054575965,-0.0011691519,0.06032103,0.003392372,-0.010125306,0.03717888,-0.05733677,-0.0032682302,-0.07328039,0.011207424,0.014634524,-0.014016343,0.08441848,-0.027066745,0.054024413,-0.04144422,0.08198563,0.074627146,-0.022899317,-0.04401213,-0.0375768,0.083840996,-0.063034736,-0.090561375,-0.004028969,0.03139259,0.032512005,0.0073582563,0.024664406,-0.034203086,-0.000366305,-0.062817335,0.08053767,0.0369685,-0.04102894,0.11548557,0.027143214,-0.06512002,0.034852408,-0.1240555,-0.0125702275,-0.007987836,0.023736715,0.0011315796,-0.060467005,0.037340973,-0.007972929,-2.4051953e-33,0.0062080934,-0.017794978,0.03217194,0.03203295,-0.0090945875,-0.013895948,-0.13745624,-0.035849746,-0.0093637835,-0.0009976933,-0.20584291,-0.079573885,0.068615854,0.06784313,-0.0064926594,-0.036524553,-0.027992614,0.04279035,0.04767889,-0.00122135,0.005173444,0.08296572,-0.03547011,0.01420881,-0.003703138,-0.0022197487,0.020733772,-0.02417262,0.06083441,-0.021424863,0.065961115,-0.029455982,-0.034466315,0.08944359,-0.013591267,0.031662285,-0.041457485,0.05248031,-0.0073874234,-0.030007474,0.002514784,-0.009905547,-0.059982922,0.015191128,0.04106149,-0.05322183,-0.0045582205,-0.008656024,-0.056905907,0.041133914,0.068262294,0.0071462695,-0.008908267,-0.04735145,-0.014963895,-0.0040999106,0.046790842,0.012414385,0.056467053,0.05263073,-0.006834122,0.046869047,-0.021259392,0.03020238,-0.008610406,0.060366638,-0.07857136,-0.09580425,-0.029335633,0.051264808,-0.06410091,-0.027539808,0.049067877,-0.04006131,0.045666687,-0.04862675,-0.027383128,-0.009328556,0.068284005,0.011832737,-0.042531565,-0.091895446,-0.07001865,0.017346593,-0.039323032,-0.010506241,-0.0004940536,-0.11571671,0.037357986,0.07734547,0.015898244,-0.023024824,-0.07745314,-0.016391749,0.10857358,-2.3221609e-34,0.03495316,-0.09296148,-0.008838849,0.019881524,0.007110098,0.08153514,0.017232219,-0.06572163,0.13418983,-0.08278446,0.108257696,0.076656714,0.005735941,-0.0020312797,0.0037888207,0.044007253,-0.051307056,0.0476598,-0.044238217,0.0016809903,0.0034430358,0.0654814,-0.042174056,0.019991504,0.047791053,0.03352161,0.0031811756,-0.048073832,0.062148955,0.020403773,0.008464225,0.010843662,0.009455056,0.011961159,-0.059582878,0.06729857,-0.0832028,0.017623095,-0.08628547,0.013942681,-0.10772641,0.031229783,0.00050687016,0.14143889,0.04838927,0.017377721,0.018174453,-0.06814526,-0.04192782,-0.0052230568,0.012193269,0.018645328,0.026403861,0.034688335,0.08247443,0.08103345,0.02406531,-0.028002629,0.0045817634,0.01683837,-0.017014936,-0.019013556,0.060621575,-0.04284733,0.04971463,-0.037996974,-0.08254372,0.04504726,0.013853785,-0.05327997,0.08591086,-0.019646486,-0.0115548195,0.047816645,0.06260534,-0.0870983,-0.10422952,-0.03487353,-0.035806682,-0.0016271857,-0.14077082,0.090690844,0.04908809,-0.0048032254,0.018731391,-0.16434018,0.00034801543,0.017935868,-0.040765587,0.058987692,-0.0145660145,0.010540465,0.031045914,0.03307784,0.10576961,-2.3392134e-08,-0.030661482,-0.009730255,0.02543914,-0.09184227,-0.053027954,-0.016490877,0.047108185,0.048321392,-0.004669533,-0.060796298,-0.023828452,0.17761981,-0.0014813637,-0.041813646,0.08430858,0.024702687,-0.04324355,-0.062885046,-0.058881555,-0.011601002,-0.037559215,-0.011790121,-0.06023961,0.0077123065,-0.07155346,-0.023226837,-0.0036845077,-0.0037597995,0.041773424,0.0057142763,0.061764,0.058756556,0.045499533,-0.07351786,-0.06594841,0.012360932,0.020405153,-0.0042915433,-0.010942169,0.01798982,0.014436912,-0.08116531,-0.048272368,0.011981467,-0.055324476,0.017625302,0.010276143,0.029708933,-0.035142083,0.040677477,0.075628705,0.03024607,-0.0011989635,-0.0058708894,-0.0875882,0.055840835,-0.057599235,-0.0024377764,0.05452853,-0.043960303,0.025056345,0.015983056,0.15755624,-0.031111877 +2.7.1.16,Ribitol and L-arabinitol can also act as acceptors.,384,1.0,-0.011226662,-0.09143248,-0.03412194,-0.023057338,-0.029226637,0.051079363,0.0036631094,-0.04191743,0.10051059,0.021426877,0.07079122,0.018477865,0.026266735,0.06544148,-0.043751642,0.036601745,-0.004659939,0.047857113,-0.055521876,0.030525208,-0.01773787,0.051341943,0.009269999,0.012249743,0.0035926339,-0.034378234,-0.015779976,-0.017506376,-0.0054476145,-0.097900555,-0.00957633,0.03958519,0.08790693,-0.0055718194,-0.0362386,0.073535465,-0.035589926,-0.0160779,0.04751711,0.016570643,0.029370233,-0.08641427,0.050915048,-0.030261425,-0.031366874,-0.041743487,-0.01428931,0.081413195,0.07367796,0.01263163,-0.06302571,-0.041111197,-0.038454957,-0.031983525,-0.039273836,0.042695645,-0.06426739,-0.036896806,-0.0037787626,-0.01348756,-0.021734832,-7.436489e-06,-0.07710593,0.020351741,-0.033734716,-0.013685855,0.025376879,-0.034246013,-0.01997667,0.035007972,0.03976184,-0.02511043,0.0009904564,0.073728584,0.0025299937,0.013162677,-0.015090575,-0.020967966,-0.0152037,0.015635625,-0.07390709,0.019428894,-0.012545938,-0.0035041657,0.0070174737,0.003695058,-0.044064883,0.04284932,-0.004195865,0.053367477,0.040546015,-0.031585615,0.09775112,-0.060669668,0.06727459,-0.077997535,0.01931604,-0.016035173,-0.055613678,-0.025863288,-0.028457588,-0.03160337,-0.047824237,-0.041366614,-0.05493033,0.007350569,-0.050194237,-0.03543235,-0.029732272,-0.08220427,-0.038192734,-0.056785077,0.00877388,0.008481617,-0.03186441,0.07514928,0.07111159,-0.15639323,0.056986116,-0.099424735,-0.05515698,-0.053916175,0.0914813,0.034023467,-0.054766253,0.019752618,-0.08459318,-4.651023e-34,-0.005100819,-0.051972356,0.05737873,0.03358492,-0.04889919,0.037798833,-0.0940824,-0.025032183,0.009934411,-0.10104611,-0.12615094,0.014440801,0.07602169,0.05242092,-0.009333129,0.06996504,-0.045834243,0.009506435,0.0060696974,0.008068908,-0.0016904144,0.11343427,-0.0036113875,0.066968076,-0.045474805,0.033744365,0.09131157,-0.07924759,0.02912994,0.027592745,0.047642983,0.009011545,-0.028188886,0.0795698,-0.053309526,0.10886769,-0.037404157,0.0011097981,0.0056190784,0.0051725954,0.015218442,-0.0021643292,-0.08136963,0.028538521,0.0730826,0.012438916,-0.022888957,-0.040121462,-0.07930621,0.04691368,0.113698855,0.0055706077,-0.017428385,-0.035029534,-0.043421652,0.039609917,-0.029053638,0.099803105,-0.053686503,0.073543034,0.005765464,0.049982637,-0.0056377663,0.048761554,-0.06825758,0.0757086,-0.062837936,-0.13359602,-0.01627907,0.021923171,0.015668215,-0.037602827,0.0882928,0.122722685,0.03744828,-0.03029561,-0.029119343,-0.0017325497,0.0215799,0.05246508,-0.0366893,-0.04708856,-0.0021770513,0.074275635,-0.104687646,0.042329613,0.06533897,-0.10909457,0.056644555,-0.015111919,0.034750056,0.0036824537,-0.027175875,0.060426872,0.051229402,-1.8320871e-33,0.08756826,-0.12656844,0.024423428,0.053596377,-0.027912918,-0.0061948756,0.020762853,-0.061493956,0.09569165,-0.009850539,0.10843,-0.011146674,0.0059124604,-0.04592397,0.021592163,-0.052334588,0.013064591,-0.012123527,-0.07127282,0.060058724,-0.05607863,0.005495375,0.050524987,-0.014747005,0.009974444,0.02073208,-0.012620656,0.016390996,-0.007531819,-0.0098087,-0.033903595,0.070550926,-0.05073645,-0.0746827,-0.027570445,0.02321276,-0.1297736,0.023465587,-0.03808665,-0.0032047029,-0.064008735,0.048954755,0.037067134,0.031585556,0.021843916,0.0010899295,0.06122482,-0.079469584,-0.070854746,-0.13403443,0.011532576,0.03869682,0.04576764,0.034027416,0.041114446,0.10869795,0.037612986,-0.000360437,0.020785958,0.0067320336,-0.0341688,-0.028548423,0.0711861,-0.036670294,0.07370924,-0.014491147,-0.009921663,-0.013749851,0.05399623,0.0005103515,0.09090237,-0.08316323,0.016888946,0.110935576,0.08985508,-0.02873671,-0.12242251,-0.071363404,-0.08664913,-0.07163755,-0.11105618,0.00800167,-0.03787801,0.01974117,0.079961404,-0.092763014,0.008120032,0.031334292,-0.0028597098,0.07754786,-0.009971403,-0.013774353,0.008625168,0.034529317,0.07929692,-2.2461167e-08,-0.0065076887,0.008719156,-0.018180132,-0.010314598,-0.038829178,0.01652615,-0.027194345,0.024644943,0.021548245,0.01401225,-0.023601618,0.11925184,0.00036698632,0.012422397,-0.004708705,0.039646585,-0.016812911,-0.045751005,-0.0038595651,0.009493544,-0.06810029,0.013844587,-0.03493275,-0.028291294,-0.07997883,-0.02727037,-0.015999798,0.020970142,0.07485273,-0.028072646,0.024055915,0.015427515,0.038626663,-0.06568467,-0.019185644,0.07505058,0.025977785,-0.021397036,0.017822793,0.03944683,0.037975166,-0.021818958,-0.04788471,0.0045007407,-0.014835075,-0.031777695,0.017235119,-0.0006292327,-0.03206973,0.035833508,0.0836726,0.054528654,-0.0009580116,-0.02133983,-0.025992367,0.016620725,-0.039714076,-0.068968214,0.102261916,0.0041727303,0.0015547229,-0.039607763,0.073477425,-0.015801061 +2.7.1.20,2-Aminoadenosine can also act as acceptor. ,384,0.99999994,0.012681437,-0.10392941,-0.10117155,-0.038573872,0.004309483,-0.010300176,0.0663894,0.05703448,0.046479557,0.05763259,0.037431445,-0.016541509,-0.025781387,0.118143484,0.0041347956,0.064986184,-0.054232128,-0.018551242,0.029955802,0.010116745,0.015877832,0.017092656,-0.015197262,-0.03155058,-0.03740576,0.0019565413,0.006056883,-0.028175227,-0.0020567076,-0.055364892,0.0059463773,-0.04329245,-0.0051681353,0.036382046,-0.039801247,-0.01222546,-0.06906782,-0.0020212086,-0.05594882,0.0031375159,0.0073044226,0.03328988,0.010279932,-0.02965628,-0.041627448,-0.026749248,0.005189441,0.07357206,0.071343645,0.0051006926,-0.015904749,-0.03925568,-0.016759994,0.049429875,0.0032337792,0.1279722,-0.16196807,-0.0068767937,-0.05002795,-0.0063376916,-0.017109727,0.011088398,-0.018956164,0.01177483,0.085878894,-0.007475591,0.0012869013,-0.05571346,-0.064917386,0.007629355,0.058825262,-0.050235208,0.022155752,-0.038579367,0.07117139,-0.03192013,-0.025731152,0.00955916,0.042594586,-0.018257169,-0.083870664,-0.02840378,0.03876122,0.023780635,0.020782905,0.044963226,-0.030615665,0.023272762,-0.010345272,0.054805197,0.086592935,-0.020020174,0.10808676,-0.041531984,0.038022812,-0.063247494,0.027672919,0.021019554,-0.006946904,0.007000056,-0.024983399,0.063575506,-0.08602567,-0.041253664,-0.028949903,0.038104728,1.9192498e-06,-0.062477876,-0.0074839974,0.003726551,-0.02014705,-0.061905008,0.07243571,0.07272987,-0.030199027,0.097094804,0.062000584,-0.022777354,0.02652783,-0.060101904,-0.025478771,0.005746992,-0.0015228678,-0.0071569737,-0.02473117,0.07407953,-0.0074434187,-1.5825139e-33,-0.023110043,-0.05857988,0.035571128,0.029683342,0.02802903,0.04874046,-0.047591235,-0.01055564,0.059369694,-0.052247223,-0.15145104,-0.07648364,0.070213005,0.0832656,-0.034259547,-0.013563617,-0.01444407,0.029808568,0.07641393,0.02026682,-0.01844159,0.14226279,-0.034265008,-0.008678393,-0.04080092,0.01106489,-0.0056301686,0.03978106,0.062229283,-0.0060453103,0.039690115,-0.020375304,-0.099946275,0.03629084,-0.024653237,-0.012250819,0.035418298,-0.014562696,-0.02575436,-0.006038783,-0.024440581,0.01873874,-0.07391189,0.062160157,0.08061497,-0.0904005,0.0054310705,-0.0336287,-0.04113992,0.021985464,0.011677953,-0.02915896,0.04385651,-0.07505365,0.0023678474,0.01587364,0.009226809,0.02455123,0.041809615,0.058571152,-0.042420696,0.043565508,0.01087839,-0.023399081,-0.054783523,0.034222912,-0.062550925,-0.11953501,-0.0070366524,0.047851,-0.058115184,-0.020216918,0.03023597,0.052298304,0.06619277,-0.08178009,-0.0035495234,0.013372578,0.01955996,-0.02478327,-0.045586176,-0.04356465,0.06202484,0.13456832,-0.021051345,-0.027664619,0.040963236,-0.12029277,-0.013081216,0.06902586,0.030729476,0.010302152,-0.11317669,-0.010003602,0.11505272,-7.6127025e-34,0.036136832,-0.0937097,-0.03415419,0.01616215,-0.019220002,0.07001057,0.039515413,-0.043852042,0.0991318,-0.076407276,0.14106236,0.028602285,0.026242688,-0.03986245,0.033613384,-0.023306325,-0.037920237,0.07645207,-0.040157747,-0.0036445942,-0.05739925,0.04352529,0.026388025,0.011360142,0.029266879,0.013721333,-0.013672032,0.030454643,-0.0027659584,0.05251651,-0.031598795,-0.013597397,-0.03882488,-0.04768152,0.023422081,0.0031792717,-0.022764765,-0.01626917,-0.07632384,-0.00603527,-0.043256134,0.039044533,0.031254184,0.11739504,0.010198806,0.019004593,0.052039154,-0.015509382,-0.12625597,-0.06442274,-0.0067989742,-0.049202543,0.0033787873,0.022705695,0.11930127,0.04335017,0.021233296,-0.08981675,0.035371352,0.040953882,0.022486355,-0.055534285,-0.011696939,-0.00593575,0.07904583,-0.04758264,-0.0857877,0.07328739,0.064895615,-0.019337567,0.084313914,-0.062240466,0.07610581,0.10296196,0.008012828,-0.020389376,-0.04220298,-0.08585061,0.024881788,-0.08822426,-0.13845272,0.038563713,0.0479448,-0.054419994,0.018030195,-0.10405944,0.08444209,0.0064362693,-0.040097803,0.072102,0.011331004,0.0020493434,-0.007031297,0.03430765,0.07583498,-2.0889354e-08,0.03307065,-0.026300248,0.04210297,-0.055185042,-0.07254403,-0.0088444315,-0.012186926,-0.020652823,-0.032754086,-0.037664764,-0.010389644,0.1130507,0.0518031,0.021374471,0.042660806,0.053006567,0.003571778,-0.008181544,-0.07550223,0.016181502,-0.114893556,0.0077755144,-0.06725061,-0.087032095,0.0064290343,-0.008655398,-0.031353164,0.06888723,-0.02386426,-0.018751524,0.016882973,-0.03522483,0.047561713,-0.06909633,-0.012886315,0.019716693,0.014672557,-0.038484473,0.03310928,-0.052730273,-0.0027208414,-0.049330045,-0.045782417,0.021828668,0.014731144,0.013832344,0.03948642,0.029166969,-0.078544475,-0.0031288252,0.041401565,0.01421252,0.06868371,-0.016870541,-0.05733787,-0.029961571,-0.07477567,-0.04394681,0.029025877,-0.0481272,-0.0077066855,0.04705541,0.10725178,0.01101953 +2.7.1.21,"Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP---thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP-kinase).",384,1.0,-0.14730303,0.0034862834,-0.030780373,-0.030372327,0.06750228,-0.0414219,0.017397404,0.12576999,0.014051126,0.048913315,8.1659484e-05,-0.01751729,-0.028680712,0.038549636,0.022444936,0.026421277,-0.060469728,0.064836584,0.026669625,-0.0009637407,-0.08811804,-0.0066837766,-0.019425236,-0.060096916,-0.023020076,0.09017073,0.005475492,0.15603106,0.041519426,-0.05361425,-0.0142841395,-0.07509217,-0.015291367,0.014274983,-0.051832136,0.105428755,-0.10902712,-0.030010978,-0.044938948,-0.016279709,0.060383916,0.060490455,-0.0073853284,0.019128095,0.011322013,-0.03249291,-0.05300633,0.082833655,-0.035352733,-0.06640183,0.07951503,0.07922448,0.01459161,0.04870751,-0.071277864,0.023864448,-0.096048065,0.040003434,-0.011428535,-0.0021337783,0.026295917,0.0060134614,0.047371637,-0.02984694,0.040155806,-0.022040216,0.036603637,0.0237567,0.07545386,-0.041797828,-0.04060654,-0.026426978,-0.022263948,0.08263119,0.026599836,0.0071660182,-0.044488806,-0.018062565,0.06494786,0.00813897,-0.05170992,-0.05609945,0.04612472,0.058794167,-0.0117963515,-0.020525372,-0.054712873,-0.0012901345,0.027715521,0.023839725,0.001178629,0.0075173546,-0.041103207,0.024095371,-0.03992819,0.047778685,0.05896557,0.08666923,-0.025223166,-0.040162914,-0.021603512,0.02797835,-0.13087137,-0.015781267,-0.005341164,-0.07684948,0.056539036,-0.041878305,-0.0030636636,-0.068821386,-0.02753894,-0.008338534,0.101385675,0.0148963,0.019784486,0.087688096,-0.067272305,-0.09073326,0.0038092444,-0.09348565,-0.014724228,-0.034350224,0.0267521,0.049338795,-0.039550822,0.036787,-0.0058886395,-4.898006e-35,-0.005676983,0.06439252,0.008999558,0.038669497,-0.0136404075,0.014357348,-0.024566287,0.024578467,-0.070615605,-0.05511206,-0.1398301,-0.032560904,0.11700007,0.06644264,-0.109793246,-0.05329142,-0.021578262,0.036134362,0.0548584,-0.03366171,0.12788086,0.107771315,-0.012039976,0.018594194,0.0312912,0.030744985,-0.054945655,0.069979645,0.061113913,-0.0068629263,-0.0750716,-0.05896084,0.009761736,0.080594264,-0.018466122,0.04234908,-0.057153977,-0.023470894,0.0351173,0.035621632,0.030860312,-0.027305877,-0.06741167,0.028158782,0.013777373,0.060230672,-0.00794415,-0.03665702,-0.08424762,-0.030460488,0.025136575,-0.024793146,0.0034478537,-0.099802464,-0.037054453,0.02800623,-0.012796758,0.012062372,0.055856608,0.059209626,0.018965371,0.075604014,-0.043536846,0.025659578,0.03048519,-0.019457752,0.0028381187,-0.061225142,-0.016445026,0.033325408,-0.055194363,0.055209424,0.058175668,-0.035833094,0.07769488,0.015906643,-0.025166092,0.06533658,0.0009907531,0.03987468,-0.07612161,-0.026759543,0.0251583,0.004523267,0.009077128,-0.058630526,-0.03321422,-0.0948626,0.008398332,0.035448246,-0.024953168,-0.03505708,-0.014605614,-0.03803671,0.059642587,-1.6722123e-33,0.011374303,-0.022827342,0.016169254,0.008363207,0.036900397,0.11718347,0.06541041,-0.047386646,0.18301237,0.0022824327,0.090657055,-0.038401514,0.011960608,-0.043510813,-0.039546654,-0.008894553,-0.02938893,0.09942414,-0.09083056,-0.040238835,-0.017573498,0.055602703,-0.010001664,0.05274428,0.0002114949,-0.011778154,0.016731406,0.022302082,0.020805659,-0.004877964,0.045867663,0.029330371,-0.045550924,0.035340555,0.02425946,0.064077474,-0.06835644,-0.0327997,-0.04911802,-0.081671834,0.015224331,-0.05204454,-0.013835997,0.0839106,0.013337157,0.073883824,0.0232417,0.022898275,0.021584412,-0.008782678,0.0018810248,-0.010969969,-0.025252892,0.046144743,0.07404055,0.029947784,0.06597382,0.026903456,0.0058690556,0.036372755,-0.018385746,-0.067117795,0.055815622,0.015934981,0.017854495,0.0074275183,-0.00836062,0.02544012,0.043470684,-0.04023705,0.09121138,0.03210669,-0.011155651,-0.031407684,-0.046718087,0.006708738,-0.037297256,-0.006679176,0.06548663,-0.10188498,-0.073568724,-0.009896752,0.03164323,-0.05070721,0.01949418,0.025828755,-0.0495927,0.05902986,-0.023191648,0.002982577,-0.057222936,-0.07630913,-0.01716905,-0.011289821,0.026602373,-4.0528143e-08,0.038739167,0.0024458,0.005892924,-0.021148471,-0.038687523,0.054619454,-0.0005710437,0.029697554,0.04689722,0.034971632,0.07887836,0.04505506,0.032508977,-0.06494105,-0.03662434,0.0061926036,-0.0345156,0.060585283,-0.012898521,-0.07149296,-0.023810795,-0.045479693,-0.046084885,0.016418362,0.055908494,-0.040548176,0.006486834,-0.008994685,0.11921268,-0.121914394,0.0090691885,-0.055622254,-0.056819,-0.00048733698,0.012860669,-0.024890315,-0.022296533,0.012828796,0.02920669,0.029291837,0.05335203,-0.07090474,-0.03142132,0.015304566,-0.09467336,0.07936721,0.016925747,-0.04069342,-0.027189147,-0.02613357,0.011642615,-0.039385416,0.023239294,-0.08513418,-0.1275921,0.030790038,-0.068290494,-0.0353555,0.00884846,-0.09487649,-0.058501124,0.01817062,0.11317534,0.05149746 +2.7.1.25,"The human phosphoadenosine-phosphosulfate synthase (PAPSS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25).",384,1.0,-0.07598101,-0.017319217,-0.02030333,-0.08061153,-0.028013635,0.023199689,-0.048838325,0.031472996,0.11500551,0.07036471,0.0032315461,0.024724687,-0.07105667,0.0054082614,-0.08560798,0.033729028,-0.11517919,0.07825823,0.042561155,-0.03432695,0.111434005,0.023525046,-0.076084696,0.035799682,0.024712253,0.05706307,0.05670894,-0.0003830907,-0.0613633,-0.047110334,-0.04888375,-0.078256465,0.008720119,-0.06102834,0.0029880852,0.17080139,-0.013414353,-0.05815352,0.046573527,-0.08251087,0.03420744,-0.030974215,-0.07140774,0.026882023,-0.0024236606,0.032166652,-0.033792008,0.047452465,0.029601071,-0.11337422,-0.007529889,-0.029664828,-0.039505016,-0.020707818,-0.0035151632,0.0147023555,-0.09285051,0.0472713,0.033295445,-0.043776188,-0.08302826,-0.0034966625,0.03807514,0.06190433,0.06003818,-0.0010501244,0.050211146,-0.038156323,-0.02841554,-0.005595003,-0.124273114,0.0042273467,0.05300943,0.06303526,0.0037790244,0.05126429,-0.054360718,-0.02547608,-0.010814986,-0.010513653,0.08086937,0.04818543,-0.020172099,0.025392478,0.025773529,-0.03464381,-0.023630222,0.036289446,0.0389437,-5.8957976e-05,0.026561964,-0.023239125,0.04510082,-0.014251036,0.004232796,0.06556546,-0.031187603,0.08736938,0.01823393,-0.06719319,0.006034264,0.0695092,-0.0052496665,-0.11651011,0.044111785,0.008173203,-0.009527035,0.037454728,0.031217825,0.069670945,-0.040199775,0.035769735,-0.017758181,-0.04713802,0.023165643,0.090129085,0.0051254947,-0.11176693,-0.066335045,-0.007930721,-0.06621336,-0.079723276,-0.011047097,0.07950341,-0.027178958,0.03028471,-0.07662098,4.0767874e-33,0.051490117,0.051549874,0.09115182,0.010140114,-0.012213966,-0.04099355,0.02214751,-0.02879535,-0.021064924,-0.053980116,-0.07031254,-0.06906459,-0.01280896,-0.010413682,0.005224964,0.05961721,-0.03869611,0.060817216,0.09073023,0.0037539552,-0.07295218,0.017103216,-0.021889389,-0.0011664917,0.039929893,0.06643878,-0.085464805,-0.02348601,0.00395477,-0.037050582,0.035635456,-0.028820295,-0.09344241,0.02142592,-0.0016239679,-0.04098753,-0.05780429,-0.016670281,0.037033647,0.06299145,-0.078895904,-0.023519935,0.025823774,-0.022369891,0.03524009,-0.02076306,-0.09782302,0.05746938,0.00029062643,0.09164953,-0.009967567,0.019650232,0.09796698,0.005474578,-0.026084162,-0.031156886,-0.0014197143,-0.08777926,0.0025092706,0.03584518,0.054213595,0.08766088,-0.011077343,-0.03153474,-0.057439618,0.0020583582,-0.07546863,-0.030669732,0.023820236,0.11721968,-0.011428447,-0.054043714,-0.0014445939,0.023328338,0.012684154,-0.0005492322,0.016252229,0.03017898,-0.030791558,0.075763986,2.6730533e-05,-0.039773297,-0.025111552,-0.0085191,-0.057141107,-0.004857401,0.019011846,-0.028922806,-0.038303368,0.05349582,0.01384672,-0.053971704,-0.057522025,0.07258856,-0.031431906,-6.286238e-33,0.14000297,-0.02468019,0.044525124,-0.11679487,-0.070576064,0.014706389,0.0152905295,-0.042059235,0.043485865,0.012585426,-0.01408978,-0.005882148,0.06575577,-0.025712494,-0.02677583,0.015552387,0.028850367,0.07453807,0.00825816,0.018352466,0.032761075,0.13886917,0.0022923097,0.10621821,0.041104697,-0.034984548,0.0078618685,0.037653822,0.03589221,0.011809363,0.010716432,-0.03233126,-0.03343711,-0.00046029355,-0.043534677,-0.0062182336,-0.05604141,0.017523088,0.035414465,0.009234386,0.04676017,0.053920563,0.012151098,-0.0008968025,0.0070013967,0.049265698,0.022678923,0.031848837,-0.0515326,-0.07488389,0.037581712,0.06664753,-0.030824678,0.06181528,0.025590623,0.054216404,-0.0061092754,0.066882394,-0.020553956,-0.07241439,-0.10135473,-0.09873539,-0.0172848,-0.024205238,-0.019232955,0.053911082,-0.040007465,-0.06284606,-0.018454513,0.029449912,-0.08495644,0.010706893,-0.022974396,0.0005682335,-0.030411545,-0.022971839,-0.04810534,-0.044401996,0.028204884,-0.037601143,-0.04713631,0.015310958,0.007860365,-0.09568577,-0.03952202,-0.041220084,0.038107146,0.054076068,-0.036639437,0.014525655,0.009403957,-0.0097278785,-0.0685216,0.03631699,-0.031815097,-4.3880018e-08,0.02536043,0.01799825,0.06071916,-0.018254848,0.011453206,0.030777248,0.071453474,0.056831088,0.043838058,-0.0030533187,-0.03951503,0.06898595,0.04821904,0.016043093,0.08848702,0.011066674,-0.060687177,0.025831543,-0.014611031,-0.08169046,-0.045348175,-0.040224936,-0.09491984,0.117997326,0.086186655,-0.0008598668,0.06473402,-0.040243994,-0.04035675,0.029492998,0.038280997,0.018710699,-0.05853629,-0.05079831,0.076972075,0.025149649,-0.054309,-0.012299043,-0.009176437,0.03553315,-0.07065524,-0.016786022,-0.04435984,0.05662955,0.039154917,0.051239956,0.018806046,0.022272952,-0.023961544,-0.016299801,0.11631007,-0.054395102,-0.029887509,-0.13264607,-0.043985974,-0.01755424,0.049156144,-0.06982147,0.00031258224,-0.052442748,0.07350264,-0.02091747,0.13383475,-0.015934244 +2.7.1.26,"The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates [5]. While monofunctional riboflavin kinase is found in eukaryotes, some bacteria have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.7.2, FMN adenylyltransferase [5]. A divalent metal cation is required for activity (with different species preferring Mg2+, Mn2+ or Zn2+). In Bacillus subtilis, ATP can be replaced by other phosphate donors but with decreasing enzyme activity in the order ATP > dATP > CTP > UTP [6]. ",384,1.0,-0.03148265,-0.06380931,-0.034206115,0.0013327107,-0.0039444906,-0.0062518353,-0.07331252,0.028138675,-0.013070613,-0.04404971,0.020541921,-0.055330396,0.015514325,0.077825956,-0.030041136,-0.04846478,-0.07526874,0.028917134,-0.011954679,0.048976157,0.023782436,0.06579724,-0.04134464,-0.06768782,-0.023694929,-0.04555237,0.04912014,-0.07910883,-0.00687709,-0.0008702276,-0.06857905,0.024487995,0.018953888,-0.038504913,0.022736464,0.11085816,0.044863284,-0.0332701,0.07113009,-0.01803843,0.007223877,0.026912954,0.058142267,-0.024689889,-0.0027714502,-0.008149342,0.11613631,-0.043433204,0.03693171,0.026713153,-0.042928986,0.017794805,-0.028766546,0.02778357,0.08553973,-0.009936183,-0.039341986,-0.061379213,-9.234502e-05,0.021836372,-0.024012247,-0.053997613,0.043268897,-0.019201644,0.10514578,-0.033646695,-0.012718608,-0.041724727,-0.012005896,-0.03346541,-0.04178159,-0.013578898,0.0005955364,-0.055005264,-0.0035566757,0.099147744,-0.037562065,-0.06461025,-0.00023785002,-0.042943366,0.031813882,0.0068479455,0.062331017,0.03926619,0.06413274,-0.08531167,0.008138684,0.010463695,-0.06994829,0.1139544,0.032474935,0.05271397,0.07283254,-0.107338294,-0.10288669,0.034410756,0.012361412,0.041387845,0.029702649,-0.027226144,-0.02372814,0.08958486,0.030415272,0.04684962,-0.020715244,-0.033576995,0.006067152,0.10869054,0.03747939,0.07203638,0.047379676,0.09072873,-0.00299612,-0.08100949,0.023145804,0.054395463,0.0048615756,-0.097080216,-0.059207033,0.0248597,-0.047229443,-0.01087569,0.031665023,0.043577768,0.012573187,0.008634142,-0.08488732,4.3506078e-33,0.002312135,-0.005482221,0.049009267,-0.0142655065,-0.009791541,-0.07161471,-0.08167125,-0.036186676,0.049668953,-0.10634864,-0.09402139,-0.004532285,0.05085747,-0.027545702,-0.056329116,-0.047528595,-0.0349487,-0.07125404,0.114643075,0.00960032,0.08542091,-0.0049265176,0.08316871,0.009302266,0.068498515,0.004860121,0.032346264,0.021219295,-0.057152823,-0.030738203,0.035229705,-0.14086293,-0.07850923,0.014964096,0.058511492,-0.036755703,-0.07058773,0.016230565,-0.06290717,0.034924086,-0.045547564,0.0004610058,-0.07105874,0.0065466845,0.07010243,-0.054133542,-0.010788097,0.07395908,-0.04452703,0.06750963,0.061407637,-0.027959436,0.035345465,-0.05404066,-0.020716542,-0.037549037,0.018487133,-0.018351091,0.012035374,0.057695106,0.038632303,0.013521238,-0.007666678,0.088391416,0.017408932,0.03845229,-0.0627983,-0.07923863,0.04346787,0.05427102,0.004992012,-0.02710986,0.11741021,0.019462463,-0.025184264,0.02661961,-0.022942344,-0.056104757,-0.023421885,0.040682815,0.041580614,-0.015552302,0.0037562686,-0.043901917,-0.058634333,-0.011646505,-0.018620297,-0.10650573,0.03245944,-0.024962293,0.092043616,-0.04438409,-0.053628318,-0.0061680204,0.021435194,-5.0135973e-33,0.13775954,-0.07747507,0.08720836,-0.1172603,-0.0982449,0.05166788,0.0126451785,-0.051282953,0.058647737,-0.0007176132,0.018247921,0.006407196,0.03313994,-0.029670628,-0.043243192,0.020506717,-0.024159856,0.08880133,0.04036637,-0.0103224,-0.058381293,0.1380027,0.0053708013,0.03840104,0.022399629,0.07233918,-0.04314965,0.044705395,0.021922085,0.0021077134,0.00047639554,0.038675006,-0.041564513,-0.086888775,-0.01947124,0.03843822,-0.03154499,0.01204625,-0.0048395237,0.035110675,-0.0033838488,0.09535299,0.015462843,0.050196227,0.009416719,0.03202704,-0.068229824,-0.062872194,0.023211515,-0.073563024,0.04980316,0.010656045,-0.050812,-0.048104353,0.042202275,0.04571574,0.048573826,0.07581971,0.07235007,-0.041701883,-0.0395915,-0.083469436,0.08557527,-0.045840815,-0.021428432,0.06102032,0.03894138,0.027926821,0.011277715,0.03947649,0.0032823659,0.030480485,0.048645418,-0.009247053,0.0003127166,0.07912242,-0.018053772,0.026857294,-0.02896471,0.014781056,-0.038266536,0.047336936,-0.1007269,-0.041583534,-0.022705298,-0.0559289,0.027108163,0.032373138,-0.033361226,-0.067374416,-0.015937896,-0.04895044,0.025142213,-0.010840653,0.0435262,-4.6793506e-08,0.005116825,0.00886941,0.0044555035,-0.03940174,0.05118905,0.029378137,-0.045853853,-0.011344605,0.07048471,-0.019391175,-0.0011015346,0.09215815,-0.00012423415,-0.03849204,0.021495605,0.0025387567,-0.06397893,-0.051722884,-0.05173671,-0.052292563,-0.051220324,-5.7337344e-05,-0.113765046,0.107865326,-0.005973523,-0.07410036,0.0021685597,0.019863533,0.011029402,-0.04791706,0.031929526,0.028032662,0.014341608,-0.056458335,-0.066815324,-0.032286115,0.015673518,0.018408708,-0.084293135,0.07060449,-0.03285666,-0.074900806,-0.07854103,0.023477934,-0.055353496,0.047358394,-0.033949826,0.10912574,-0.025500048,-0.03559455,0.082104266,-0.028448107,-0.05282015,-0.031860754,-0.07032983,0.058664624,0.019127397,-0.040950503,-0.019365583,0.0069526043,0.0159127,-0.027841076,0.113949314,-0.057879407 +2.7.1.27,"The enzyme has been characterized from the bacterium Propionibacterium acidipropionici (previously known as Propionibacterium pentosaceum). cf. EC 2.7.1.215, erythritol kinase (L-erythritol 4-phosphate-forming).",384,1.0,-0.08436252,-0.088065214,-0.12619002,0.036065277,0.001797362,0.047849007,-0.041163687,0.06493648,0.06259858,0.015348926,0.008999743,-0.04219196,-0.06178306,0.032680452,-0.010185886,0.053996313,-0.020577421,-0.02288868,-0.029102674,-0.026440343,0.092101365,0.044464152,-0.004254361,-0.01093211,0.08554812,0.03180664,0.09705931,0.044310138,0.02774286,-0.06389918,0.016046213,-0.06533152,0.09077436,-0.04043315,0.11401564,0.03095829,-0.094976954,-0.105469786,0.03924188,-0.016978966,0.07974145,-0.01343146,0.031826764,-0.0069302265,-0.046489198,0.043237235,0.037762348,0.048131373,0.070655584,-0.005066865,-0.007867081,-0.08712738,-0.03454874,0.020344742,0.001960931,-0.0562556,0.03826655,-0.042726677,0.044472575,0.021355025,0.08105634,0.033957843,0.034331292,-0.015894225,-0.07264644,0.001255126,0.026001424,-0.09890072,0.033879798,-0.042148344,-0.08655187,-0.023052493,0.06471699,0.1525739,0.009513971,0.017237369,-0.050085157,0.01157799,0.0371426,-0.0377299,0.045199495,-0.0047656875,-0.052288253,0.10291408,-0.042613067,0.011295132,0.007821547,0.07528082,0.0617305,-0.027198372,0.0113866525,-0.043792307,0.007079651,-0.037924167,-0.09393933,0.01922062,-0.05453963,-0.005336465,-0.0035888676,-0.0457749,-0.026919397,0.10690456,-0.022981675,-0.068148956,-0.029311487,-0.03280327,-0.033871666,0.07643358,0.013393775,-0.019266477,0.043351457,-0.0021439367,0.031914774,0.02798259,-0.000761896,0.008851839,-0.017525313,-0.06700776,-0.0521285,0.016230302,0.020830791,-0.01874707,0.00997715,0.036157377,-0.027237294,-0.02190486,-0.107926026,3.5837928e-33,0.06734544,-0.009425031,0.02693985,0.004996445,-0.042236708,-0.022574889,-0.0060223616,-0.05631458,-0.016367326,-0.063244924,-0.048774447,-0.088990435,0.037517995,0.055569407,-0.06744335,0.06144793,-0.00040425916,0.04085194,0.042352784,0.05822094,0.02170491,0.075272374,-0.039110646,-0.034642767,-0.0062559512,0.072465636,-0.012279956,-0.0054281866,0.10621532,-0.013997285,0.055802137,-0.08421427,-0.06967867,0.026143907,0.045028955,-0.060362983,-0.025580438,-0.014687932,0.013846441,0.046535853,-0.024791975,0.058414336,-0.044808317,0.053937126,0.05861707,-0.01085826,-0.039954092,0.08823431,0.036482237,0.02681497,0.0029390077,0.018928146,0.12910978,-0.04044352,-0.07478036,0.017297857,-0.014179584,0.05059992,0.054722644,-0.00022940776,-0.0037254991,0.1011707,-0.071841046,0.08195635,-0.005422869,0.062710084,-0.024692073,-0.087741904,-0.0065160664,0.12056801,-0.024003917,-0.031397235,-0.0089677265,0.018182952,-0.045640945,-0.07919932,-0.055484585,-0.033715907,-0.07780709,0.033258952,-0.0969346,0.012807996,-0.006827933,0.011612623,-0.1044225,-0.05545755,-0.007711356,-0.054291453,-0.0566141,0.021859193,0.033439927,-0.07315168,-0.0772499,0.09345199,-0.043063443,-3.4804647e-33,0.08863442,-0.037915368,0.026356297,0.020744322,-0.044967245,0.026334006,0.0003088638,0.038566567,-0.0109385615,0.052188892,0.14458233,0.027764082,0.014142344,0.00864683,0.039301272,0.00036930913,-0.023331802,0.048751842,-0.008543263,0.025967652,-0.03879901,0.049256574,0.010379964,-0.048008267,0.02426177,0.029262532,-0.02206919,0.004371518,-0.07824491,0.007471789,-0.006539666,0.03606808,-0.029378042,-0.08959753,-0.11269824,0.03216991,-0.011578222,-0.084860824,0.030248595,-0.014852122,-0.0051347576,0.050005205,-0.033465937,0.053148564,0.01137698,0.009583407,-0.02285539,0.08377834,0.054898284,-0.06052718,-0.047585316,0.0059772287,0.009381204,0.009515741,-0.0013339557,0.0015469898,-0.019649893,0.015027354,-0.014430931,-0.012714276,-0.08595381,-0.10695967,0.121180736,0.03351599,0.02293602,0.08002383,-0.00021783894,0.055622526,0.04771555,0.007203308,0.07745602,0.04297491,0.012882477,0.09349171,-0.047148768,0.001976932,-0.034866393,-0.03647739,-0.018002441,-0.0067369165,0.0024109522,-0.005244643,-0.059213944,-0.040929187,0.005773607,-0.03287807,0.024044577,0.109169915,-0.01412418,0.07455751,-0.011391128,-0.039292406,-0.093923114,0.12052022,0.034921363,-3.801022e-08,0.002438799,-0.034619655,0.07236741,-0.042042654,0.0408792,-8.802101e-06,0.011557214,0.043254595,0.064977884,0.0069951327,-0.005432654,0.008875554,-0.05104116,0.016411055,0.015688064,0.039153855,-0.027810387,0.0018649627,-0.026893053,0.0013952624,0.046587147,-0.06861564,-0.09109084,-0.0069428384,0.06430779,-0.078807704,-0.025315022,-0.005631887,-0.079036586,0.008071452,-0.02859195,-0.011405314,-0.02847086,-0.03582945,-0.060696777,0.06803802,-0.06263225,-0.032599896,-0.0272111,0.064830914,0.01623682,0.018999923,-0.069869526,-0.0117275305,-0.016646832,0.019165754,0.037253413,-0.008113557,-0.024716219,-0.06985873,0.011804754,-0.06661901,-0.027300527,-0.027054472,-0.110731475,0.066252016,-0.04462165,-0.00585225,-0.006235171,-0.015709942,0.061717294,0.008460285,0.15045434,0.025638646 +2.7.1.30,"Glycerone and L-glyceraldehyde can act as acceptors; UTP (and, in the case of the yeast enzyme, ITP and GTP) can act as donors.",384,1.0,-0.047632094,-0.04524274,-0.0019267375,-0.04390488,-0.017737018,0.008600041,0.024381576,0.014347429,-0.024690378,-0.029969085,0.06707944,0.008879169,-0.12715876,0.09751349,-0.05401648,-0.0241161,0.045043796,-0.012362815,-0.025198624,0.03806927,0.04170163,-0.026449686,-0.004139571,-0.047483638,0.06378364,-0.042481616,-0.017516075,-0.024485888,0.039913353,-0.08890024,-0.077238455,-0.068929635,-0.0014285875,0.012392731,-0.029494902,0.06222845,-0.009296122,-0.0136424275,-0.0071917227,0.032250963,0.030506477,-0.08161078,-0.04054217,0.042012297,0.0015254398,0.038861945,0.03274553,7.998945e-05,-0.043052997,0.009963242,0.04511757,0.0023975875,0.032260727,0.042612925,-0.065475576,0.011588145,-0.072163194,0.011687403,-0.03295358,-0.024345394,-0.045747597,-0.00487076,0.023440909,-0.0031182403,0.04237805,-0.05820577,0.08316437,0.003830909,-0.03464904,-0.0055923676,0.072518304,-0.061223123,-0.037326735,0.018848011,0.07248092,0.09857043,-0.04030296,0.034742784,0.04255163,0.021062817,0.046783477,0.036958758,0.06303349,0.05297351,0.026464397,-0.040691886,-0.021144077,0.101754546,-0.045133866,0.035089135,-0.0037150665,-0.0141183445,0.029154407,0.013737789,-0.03221222,0.008270539,-0.009217189,-0.029977886,-0.031406414,-0.056512233,-0.050398238,0.078603365,0.0059609865,-0.02411502,-0.047427434,0.05777742,-0.058360524,-0.042773325,0.0769841,-0.053729977,-0.007290088,0.028797781,0.049869142,0.029308766,0.00076232554,0.0035903067,-0.039610654,-0.061824758,-0.052855916,-0.101221964,-0.043122742,-0.03577541,0.012568848,0.018520337,-0.05808002,0.03871656,-0.04059479,-1.636807e-33,0.026882714,0.027202781,-0.04710344,-0.018959654,-0.042655434,0.019568179,-0.039654996,-0.008848392,-0.080972046,-0.07606263,-0.05485444,-0.026336959,0.008639137,0.11788783,-0.05963093,0.07756494,0.0075585134,0.016094226,0.07781426,-0.07167515,0.05704249,0.08396203,-0.045390524,-0.052424844,0.036324803,0.07195137,-0.036790706,0.021715945,0.037742738,-0.028756378,0.060996916,-0.12282845,-0.001946721,0.06775529,-0.006162528,0.042407986,0.04334113,-0.06920542,-0.009862528,-0.029294128,-0.030428112,0.013580354,-0.0034291113,0.03548738,0.054658677,0.02823956,-0.04386205,-0.12133982,-0.061897304,0.077646375,0.012661063,-0.023103764,0.006588569,-0.016072452,-0.03891178,0.051015023,-0.010618101,0.065414056,-0.03822255,0.0011242348,0.008878598,0.13550921,0.015612145,0.011069682,-0.067897186,0.043249592,-0.048243433,-0.09396453,-0.018239876,0.08916186,-0.09623491,-0.01196341,0.03373252,0.031251933,0.019526005,-0.11173603,0.0056268177,0.020456988,-0.013824591,0.031836264,-0.069177136,-0.100334615,-0.02784966,0.023047203,-0.0798484,0.00024703314,0.016559966,-0.12924549,0.04873203,-0.05145094,0.027801124,0.008258845,0.019065168,0.022733696,0.027382284,-7.1765615e-34,0.16529684,-0.090277195,0.118135035,0.022310492,-0.022395257,0.07763398,0.039810523,-0.0940836,0.035783194,0.026786713,0.027968088,-0.030887801,0.06514501,-0.039850436,0.06349806,-0.050095275,0.006260826,0.04463091,-0.06507555,-0.015752511,-0.033414636,0.08995232,0.01340902,0.03008885,0.062584035,0.014174201,0.018654903,0.02762523,0.053538863,-0.0271282,0.03237934,0.0774185,-0.08754939,-0.14662044,0.010882129,0.038516596,-0.06952023,0.051932607,-0.047490966,-0.033303335,0.050166544,0.0065925005,-0.014861143,0.1045732,-0.009169538,0.058992933,0.0011382188,0.0033865336,0.0693529,-0.037771896,0.017510902,0.044889506,0.0041589863,0.0555728,0.1234002,0.05550695,0.06639162,-0.05271438,-0.016060125,-0.014102642,-0.041980565,-0.038454887,0.063706115,-0.012786269,0.015105909,0.02753418,0.012479804,-0.030571964,0.050665632,0.07099259,0.08029606,-0.06353745,0.05925149,0.08072536,0.013569654,0.01198874,-0.12452684,-0.069209956,0.023848439,-0.079666734,-0.022932095,0.008892411,0.04377883,0.03251669,0.07246757,-0.12589476,0.0068816394,0.094775215,0.01583004,0.029680686,0.016081642,0.002557641,0.00930216,0.008048893,0.030049527,-3.2204802e-08,0.05870258,0.006932797,0.012814049,-0.10244694,-0.083385706,-0.008210352,-0.023077268,0.005968266,-0.010094717,0.02715483,-0.049763378,0.06944086,-0.025688462,-0.06540279,0.059112802,0.020022277,-0.01382499,0.003462002,-0.027783716,-0.019099295,-0.12785691,-0.031465936,-0.06864068,0.05384474,-0.018225996,0.028332967,0.03469335,0.04285814,0.016446186,-0.015980871,0.03049662,0.007765495,0.00082077744,0.034168065,0.027910698,0.052956447,-0.02635788,-0.036049396,-0.008563412,0.008572811,0.002548574,-0.050860364,-0.03143037,0.030001782,-0.061787482,0.015774915,0.06634591,-0.07369777,-0.044424027,0.036265485,0.055835888,-0.05843051,-0.039720457,-0.037720606,-0.09142235,0.03532268,-0.026668394,-0.018427959,0.04098741,-0.08250552,-0.03902481,-0.02099876,0.12685245,-0.04149232 +2.7.1.32,Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. ,384,1.0,-0.006728437,-0.04232756,-0.062099725,-0.012978761,0.08624006,0.019423125,0.007927352,-0.008691769,0.016447403,0.020961687,0.1034133,-0.008087874,-0.101421244,0.1093349,0.03324346,0.06667703,-0.057995636,-0.034623057,0.038978174,0.07249057,-0.00015147486,0.043603394,0.016090022,-0.028058082,-0.049788143,0.07591075,-0.0030352026,0.040396303,0.0756124,-0.065355144,0.0071711577,0.07809122,0.019505141,-0.012145785,-0.03586693,0.0051938994,-0.04382547,-0.02950992,0.01628997,0.012923229,0.054476615,-0.009336078,0.033938974,-0.008501989,-0.09539039,-0.046494335,0.041782923,0.013050679,0.013102713,-0.06810406,0.080142386,0.021439817,0.028070863,0.058910556,0.030503167,0.0040631,-0.09108048,-0.004903747,-0.072423205,0.0068166675,-0.008438186,0.018200181,-0.09389013,-0.005557632,0.002150301,-0.023181578,-0.009055053,-0.035758276,-0.010668969,-0.0057820682,-0.02565901,-0.06261359,0.07249553,0.02982426,0.057054024,-0.029248305,0.009670835,0.006792569,0.021442655,0.020663667,-0.114873275,0.009496791,0.04277318,0.011909135,0.07270655,0.035132058,-0.06755896,0.046144836,-0.01162769,0.030735271,-0.04871733,-0.034479585,0.029043911,-0.0889455,0.03148901,-0.01641724,0.09552175,-0.03873233,0.009707905,-0.012428471,-0.00964513,0.05154908,-0.12302911,-0.09234715,-0.082895815,-0.025250543,0.022935526,-0.0154206725,-0.022749925,0.017385656,-0.059882097,-0.049939163,0.06374992,0.059846718,-0.06998843,0.038387917,0.015999421,-0.069047086,0.01864473,-0.113934,-0.05377837,0.03987385,0.04357191,0.052084267,-0.015875772,0.0028368235,-0.02398083,-3.5638476e-33,-0.07132334,0.020012831,-0.062348604,-0.053582612,0.013622468,-0.0022130662,-0.029424226,0.048820507,0.018914098,-0.090637945,-0.08230495,0.007109141,0.041273143,0.0946709,0.02475524,-0.054327942,-0.01068223,0.06580285,0.08542602,-0.06510727,-0.0047379965,0.054630153,-0.047503036,0.028341155,-0.082577914,-0.003307972,0.04976676,0.017006474,0.07558845,-0.043552887,0.04170498,0.02187002,-0.015037082,0.031586062,-0.009914816,0.1413763,-0.015700903,0.030312499,-0.027070489,-0.027499113,0.018083077,0.058911286,-0.040028088,0.056908853,-0.0036781717,-0.007087693,-0.079657026,-0.0446891,-0.0011130484,0.020794379,-0.011982761,-0.01312732,0.01058383,-0.061131496,-0.082826816,0.028510246,-0.018186077,-0.0077298153,-0.09055159,0.018429423,-0.092935346,0.008780325,-0.06034772,-0.021120053,-0.05686429,0.028614,-0.017034344,-0.10674592,-0.019236868,0.02070013,-0.076650694,0.00271024,0.061143998,0.032762267,0.04185356,-0.0023676376,-0.08097713,0.012086436,0.052983783,0.015935274,-0.06932772,-0.07995436,-0.029622817,0.063396156,-0.058153443,-0.075615555,0.021927858,-0.040968336,0.056805085,-0.0016167612,0.046806265,-0.08974776,-0.00879037,0.026549002,0.06419677,-2.1905328e-34,0.051723186,-0.07205495,0.016205179,0.0077934866,0.06475837,0.09484568,0.05313399,-0.07017283,0.0378112,-0.07017786,0.05897358,0.03387837,-0.025949018,-0.006254061,-0.016371515,-0.008215877,-0.043130532,0.102387115,-0.03861497,-0.011095987,-0.050402008,0.07157624,-0.0063136164,0.029173382,0.028282573,0.048793387,0.009268952,-0.0049841637,-0.002509433,0.03888464,-0.028903574,-0.04095345,-0.034209706,-0.05402455,0.023410419,0.07410383,-0.033723142,-0.012314984,-0.14550492,0.017476972,0.03871769,0.010672784,-0.032279793,0.09437274,0.02116983,-0.009917308,-0.03888051,-0.0025368994,-0.060678143,-0.005871999,0.038936116,0.026575282,0.027218787,-0.050458755,0.0711595,0.07015966,0.07157172,-0.06883392,-0.013286184,0.021789076,-0.042622525,0.063888855,0.034592077,0.0045771906,-0.0025162927,-0.085540116,-0.03170636,0.053026564,0.042434562,-0.034529507,0.12330514,-0.01304847,0.074319236,0.11726843,0.047690663,-0.123062834,-0.014187136,-0.08555253,-0.034003165,-0.020616725,-0.03299755,0.029431807,0.023619236,0.02578013,-0.011135408,-0.0068091666,0.041570537,-0.018450232,-0.02201115,0.018567506,0.063530535,0.039548375,-0.036452115,0.08723878,0.06336832,-2.1651463e-08,-0.026282113,-0.06678723,0.01241283,-0.014908143,-0.07990774,0.040716793,0.04439745,-0.0076091164,-0.012581246,-0.030515414,0.041575465,0.081330255,0.043438155,0.013024055,0.046361614,0.0017231785,-0.0322031,0.002455124,-0.06537351,-0.046098936,-0.12879737,0.0014342205,-0.035335578,-0.0048965407,0.0074364017,-0.0044114217,-0.07804781,0.07187294,0.003694197,0.015140917,0.03308561,0.059325192,0.0070414804,-0.010140481,0.023028092,0.035254538,0.06280751,-0.07027631,-0.05581514,0.044385325,0.030144608,-0.054294888,-0.09684362,-0.000894351,0.060494255,0.0043793344,-0.021657316,-0.012554667,0.0018559025,-0.004296478,0.05628654,0.032687534,0.05930707,-0.016021857,-0.07335845,-0.030927068,-0.13150142,-0.05008434,0.008294011,-0.055151835,0.06431367,0.025169771,0.19912258,0.043957148 +2.7.1.35,"Pyridoxine, pyridoxamine and various derivatives can also act as acceptors. ",384,1.0,-0.017205393,-0.07965395,-0.044918206,0.009484945,0.09779499,-0.0025258565,0.044709,0.008778822,0.03702284,-0.0013829698,0.08871277,0.0012710768,-0.06398229,0.13226339,0.018640578,0.05731203,-0.061511073,0.041298635,0.041742392,0.043727934,-0.034075763,-0.0037164944,0.0049767294,0.020029904,-0.07742352,0.06542934,0.041842554,0.03434702,-0.0042926287,-0.07668321,-0.06443649,0.012799515,-0.020403028,-0.0246401,-0.011800299,0.04096336,-0.15293428,0.054183137,-0.005065633,-0.006542965,0.032561217,-0.06558764,0.039357163,-0.01207384,-0.06567626,-0.020031163,0.08335394,0.0037571436,0.027548349,-0.046106976,0.013150113,0.02700176,-0.023388373,0.0766516,-0.011717223,-0.0014596065,-0.08257652,0.010501514,-0.0061547607,-0.055923913,-0.042450137,-0.037385378,-0.037274204,-0.035910707,0.010599053,-0.022428153,0.004505683,-0.018114416,-0.0024058328,-0.0053306655,0.049437672,-0.021226032,0.06364628,-0.029289123,0.079199046,0.0788296,-0.046813685,-0.002965454,0.03308446,0.06401386,-0.075045,-0.02356623,0.06355287,0.07177057,0.09228666,0.051822208,-0.05629907,0.039603937,-0.03759129,0.04210955,0.0051738783,-0.015261926,0.08493813,-0.00039772602,-5.799212e-05,-0.03426088,0.061929215,0.020565663,0.026480345,-0.016621277,-0.043541092,-0.0036491328,-0.15716133,-0.03154743,-0.04278051,-0.027262844,0.024913708,-0.04070998,0.009155355,-0.011943204,-0.08525891,-0.05612114,0.038531307,0.0395642,-0.036222804,0.0072375173,0.061080523,-0.033924144,-0.008198072,-0.009829329,0.008272036,0.036213234,0.008061086,0.026176574,-0.023077516,-0.01000793,-0.040605187,2.702e-33,-0.04756256,0.0850917,-0.021791445,0.0073622703,-0.0080462545,0.008417526,-0.064460516,-0.067928545,-0.008633163,-0.049067367,-0.10410906,0.03917423,0.023265645,0.083030656,-0.019503545,-0.07474421,-0.046058282,0.0445417,0.090570286,-0.08320959,0.06971,0.05441916,-0.03330711,0.07816821,-0.05551031,0.046605878,-0.027518313,0.05980805,0.0154713495,-0.038175516,0.056984287,-0.027509868,-0.039627295,0.031213984,-0.016031034,0.061109427,-0.01724152,-0.012372506,-0.055944875,-0.04310587,-0.062277693,0.0021910982,-0.14192647,0.027793963,0.067603424,-0.07400382,-0.08505519,0.019329488,-0.007164473,0.015299318,0.0033931856,-0.045839444,0.008034642,-0.07089102,-0.06816301,-0.065243736,-0.0024392118,-0.042725783,-0.00055732264,-0.0022855704,0.016906975,0.02906172,-0.033308625,-0.03166357,-0.04410246,0.016929198,0.053354666,-0.0790853,-0.022260306,0.0060290606,-0.033384368,0.012896718,0.007897189,0.04393542,0.020294411,-0.062097937,-0.11325486,0.0115325665,0.03798655,0.002067146,-0.07608136,-0.11146262,-0.02277207,0.09850314,-0.058300454,-0.056507286,-0.003820326,-0.054531008,0.05672705,0.017884308,0.0035032812,-0.07914389,-0.023198448,0.021406122,0.038116284,-3.7562305e-33,0.031853974,-0.051661376,0.06960984,0.024824806,-0.005548456,0.100667715,0.041414384,-0.046369717,0.13912089,-0.045000628,0.023593882,-0.005709607,-0.013002754,-0.005618818,-0.028244253,0.004629583,-0.032139108,0.07872528,0.018044723,-0.014149287,-0.057889387,0.033322733,-0.08757322,0.03622484,0.046054076,0.11453026,-0.009309395,0.01111103,0.04160649,0.058691666,-0.06501835,0.043891117,-0.0020999028,-0.063536264,0.018086493,0.05744621,-0.043781262,0.055567864,-0.072842605,-0.019138582,0.049049288,-0.008113577,0.01786577,0.11056276,-0.023330374,0.016543446,0.03174835,0.023854643,-0.0035164966,-0.019297196,0.03978585,0.06854704,-0.014426318,-0.037962854,0.08588599,0.066607125,0.024087746,-0.09812687,0.04362775,-0.02643245,0.0008461694,-0.0398024,0.025635308,0.03486377,-0.008664544,0.023294901,-0.0025525664,0.021341316,0.08510791,-0.0027098993,0.11098682,0.011066705,0.08906153,0.06964438,0.018552672,-0.07825486,-0.012655518,0.005828328,0.04550917,-0.018548934,-0.012036409,0.017869003,0.04208452,-0.06845822,0.03750397,-0.07743433,0.019393535,0.0117019005,-0.007046161,0.00067040656,0.068269186,0.0031361133,0.06110925,0.045840036,0.07669558,-2.8371149e-08,0.03026,-0.06562887,0.009218785,-0.067781545,-0.043704167,0.011252761,0.052500974,-0.025501305,-0.025246553,-0.0358536,0.04520431,0.07973526,0.08276902,-0.059104633,0.092241734,0.024172606,-0.027766194,0.031040836,-0.045307167,-0.03240988,-0.13479388,0.024992518,-0.056100223,-0.04714079,0.030202644,0.0015286027,-0.031750865,-0.014237495,-0.013819063,0.023506794,0.052123196,-0.007818275,0.040806033,-0.06748081,0.01732172,0.101836525,0.015649404,-0.07885797,-0.038342014,-0.007758992,-0.0429369,-0.096179634,-0.07003456,-0.0154238045,-0.002342512,0.013942208,-0.06951784,-0.026360506,-0.055502396,0.0034164619,0.07528639,-0.007373383,0.034723323,-0.045642626,-0.120156646,0.08251634,0.012434553,-0.03818831,-0.0112783685,-0.14384739,-0.005422465,-0.005940703,0.15145658,-0.017704342 +2.7.1.36,"CTP, GTP and UTP can also act as donors. ",384,1.0,-0.106089085,-0.0052548004,-0.0045922073,-0.078420945,-0.05230532,0.04521239,0.048583124,0.023679122,-0.01235015,0.012665759,0.029453339,0.00209974,-0.037072778,0.06966811,-0.007341276,-0.023318486,0.03815317,-0.01012963,0.05566957,0.05081121,-0.033908967,-0.05399217,-0.05617807,-0.024645329,0.08176736,-0.034588672,-0.014560771,-0.00570156,0.038741387,-0.025497109,-0.053986482,-0.004902525,-0.043951422,0.019247426,0.0074017867,0.10573148,0.0091339685,0.002792897,-0.051229194,0.026469471,0.04604328,-0.027827263,0.008386283,0.050297778,0.04794164,0.007419416,0.048077356,0.045023773,-0.06883759,-0.011178648,0.09224659,0.05496397,0.02061569,0.07493437,-0.06209182,0.018180992,-0.032731563,-0.064890824,-0.050113034,-0.03684674,-0.02898498,0.058753476,-0.027514325,-0.021193398,0.06924011,0.08265508,-0.0040612533,0.01690441,0.018242637,-0.09848659,0.0178324,-0.027261674,0.024813326,0.035436403,-0.01021932,0.080275424,0.012731642,0.05078908,0.018999625,0.012618247,0.011486424,0.09716471,0.0065902914,-0.041112233,0.0779755,-0.009066096,-0.053400498,0.0051281517,-0.0322862,0.06561786,-0.05479308,0.02657285,0.098544754,-0.010018256,-0.060692813,-0.035051722,-0.027521,-0.031225404,-0.033530667,-0.025755247,-0.05208209,0.10057726,0.06028036,-0.02268812,-0.027744882,-0.07615048,-0.07035038,-0.04843732,0.056606047,-0.0014620674,-0.018559325,0.078379296,0.010341433,-0.005688127,0.031255633,0.06429267,-0.17990954,-0.025864458,0.020194128,-0.048556946,-0.014339224,-0.016212435,-0.09058177,-0.0071666916,-0.039861333,-0.018396255,-0.07074538,-5.7088117e-34,-0.05371292,0.06076061,0.05429884,0.019899389,-0.023944957,0.0337063,-0.035830215,-0.044473134,-0.044270273,-0.061118945,-0.050135575,0.025447197,0.070568554,0.034268063,-0.06829425,0.027606297,-0.12666982,0.04040583,0.05287567,-0.011631504,0.041763287,0.13001211,0.016452076,0.02711246,0.09629348,-0.006938952,-0.13190675,-0.014471049,0.08813559,0.006999505,0.0012536696,0.020874543,0.014336874,0.054288942,-0.037183333,0.03823162,-0.0008250494,-0.085650004,-0.027377179,0.010375624,0.022994496,0.018892808,0.055462956,0.040655777,0.024248606,-0.044727046,0.018763548,-0.11917812,-0.10127252,0.057037022,-0.011785572,0.010934677,-0.088984914,-0.0933006,-0.02404036,-0.089251705,0.003102974,0.040416732,-0.022422545,-0.015066867,0.053336818,0.017695742,-0.0034325288,0.008821886,-0.13259834,-0.002060695,0.020442063,-0.113466516,0.04855664,0.040151898,-0.04161852,0.06415602,0.02358159,0.045237973,0.0051115165,-0.044382516,0.009655388,0.04481402,0.08156512,0.060958076,-0.07286272,-0.087067135,0.016461153,0.049701087,0.054074675,0.005188121,0.055431288,-0.057171788,0.039814655,-0.06026742,-0.027747447,0.02111111,0.006407304,-0.038958255,0.03610388,-1.5903072e-33,0.016909096,-0.10244654,-0.014369532,0.026380075,0.023561819,-0.032813035,0.031060409,-0.15990955,0.076465026,0.06495571,0.02429918,-0.043671325,0.07914714,0.052798357,0.044076096,-0.07112779,0.01750252,-0.005598345,-0.052687436,-0.026026633,0.028993644,0.09166504,0.048124112,0.014112568,0.030257432,0.024099918,-0.08742104,-0.037184916,0.095443,-0.038267273,-0.020903053,0.05077283,-0.12501627,-0.051634192,-0.07612479,0.03441662,0.015565214,0.0388162,-0.016414197,-0.05299681,0.108116165,-0.059518926,0.025367524,0.07590825,-0.08584144,-0.0021644684,0.067996405,-0.045408018,0.0294092,0.0065710396,0.0062390123,0.006121685,-0.021905465,0.036903586,-0.028657785,0.04853353,0.04672568,-0.06759151,0.005916379,-0.036427554,0.030718025,0.021370502,-0.030290911,0.027817648,0.012633066,-0.047436737,0.06435245,0.032199718,0.008407068,0.055753876,0.054275647,-0.03536588,0.050503258,-0.056176208,-0.04066043,-0.012198065,-0.069795884,0.026085455,0.046261758,-0.12770438,-0.006705126,-0.06763779,0.06168967,0.060747523,0.045337915,-0.033977997,0.054547936,-0.020294825,0.06589199,0.03563509,-0.06018783,-0.008843666,0.038878493,0.021967972,0.0047202655,-2.1947878e-08,0.032817084,0.06151952,-0.07758342,0.013857187,-0.013675788,-0.024478072,-0.06879325,0.04003474,0.0038225371,0.066114716,0.023796663,0.055330876,-0.046718303,-0.070802264,0.0455005,-0.013901538,0.009309895,-0.02278065,-0.028730726,-0.044013906,-0.13099338,0.017802633,-0.024849724,0.070104174,-0.056157563,0.08805507,0.017988045,0.009323554,0.067400336,-0.023355149,-0.010747652,-0.0043272628,-0.087893516,0.020963509,0.018090622,0.017433243,0.048496496,-0.0317396,-0.034413073,-0.026004836,-0.0029782797,-0.07403472,-0.07660644,0.053798556,-0.02290857,0.033968568,-0.012070044,-0.07968963,0.01414695,-0.024165278,0.026252715,-0.04060347,0.016767638,-0.016603217,0.028356124,0.018818464,0.034561504,-0.0010127795,0.0603685,-0.045379326,-0.03125207,0.022228593,0.08928477,-0.020707704 +2.7.1.37,"A group of enzymes that are under review by the NC-IUBMB. Other present entries are EC 2.7.1.38 (phosphorylase kinase), EC 2.7.1.99 {[pyruvate dehydrogenase (acetyl-transferring)] kinase}, EC 2.7.1.109 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase), EC 2.7.1.110 (dephospho-[reductase kinase] kinase); EC 2.7.1.112 (protein-tyrosine kinase), EC 2.7.1.115 ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] kinase), EC 2.7.1.116 {[isocitrate dehydrogenase (NADP+)] kinase}, EC 2.7.1.123 (Ca2+/calmodulin-dependent protein kinase), EC 2.7.1.124 ([tyrosine 3-monooxygenase] kinase), EC 2.7.1.125 (rhodopsin kinase), EC 2.7.1.126 ([beta-adrenergic receptor] kinase), EC 2.7.1.135 (tau-protein kinase) and EC 2.7.1.141 ([RNA-polymerase]-subunit kinase). Some enzymes are activated by cyclic GMP, but not by cyclic AMP, and some enzymes are not activated by either.",384,1.0,-0.06233399,-0.01939693,-0.15281263,-0.04846527,0.11428628,0.017964596,-0.090261854,0.06789986,0.03853796,0.021233123,-0.0030714942,-0.07486482,-0.04993885,0.028256005,-0.046855535,0.07270283,-0.043170396,-0.011043679,0.011569981,-0.05167674,0.01239961,0.03199624,0.015300456,0.004509164,-0.0066481656,-0.018085958,0.010168952,0.069726825,-0.067526616,-0.118291795,-0.059704192,-0.045157317,0.01080021,-0.01960196,0.072406426,0.1168226,-0.08453654,-0.1021471,-0.006350032,-0.011306324,0.11105468,-0.0019129171,-0.013333036,-0.023601968,-0.021816596,-0.02683124,-0.04091338,0.021394318,-0.01955524,-0.008066379,-0.02914926,-0.020202115,-0.001860643,0.07945206,0.019014234,-0.01080832,-0.06776297,-0.008927403,0.005318394,0.010061965,0.011919441,-0.034729257,0.044541147,-0.012126586,-0.008383416,0.03502874,0.027010864,-0.043193426,-0.006807395,-0.040268812,-0.121788695,-0.05149432,0.032730438,0.06132932,-0.05254945,-0.026045432,0.0140672615,0.04510675,-0.008265038,-0.08894992,-0.031469364,-0.010961962,-0.005848772,0.0051509086,0.015356615,-0.02322111,-0.010621739,6.785401e-05,-0.006001487,0.05783902,0.12500542,0.0078036096,0.04363,-0.040622536,-0.01820034,0.013934231,0.02402351,0.09288988,0.009293818,-0.047620393,0.0328965,0.095793806,-0.037033994,-0.08390281,-0.024940934,0.017852949,0.05295703,0.047181603,0.0362373,0.032764208,-0.03842975,0.034834303,0.06697471,0.021832513,0.057301465,0.108140945,0.01666087,-0.04451239,0.013483629,0.032000918,0.032166842,-0.038096473,0.08060345,0.010964198,-0.031318337,0.10938488,-0.15375727,5.3509836e-33,0.038210634,0.06118675,0.01896319,0.020661563,0.020178273,-0.03652048,-0.028169796,0.039822448,-0.05501483,-0.062276118,-0.04164479,-0.028771069,0.09701753,-0.02599136,-0.056387696,-0.020574233,-0.016910437,-0.052586455,-0.012607313,0.01842243,0.061807714,0.04070005,-0.02738473,-0.011258799,-0.007296201,0.040317364,-0.05940532,0.039406065,-0.024897806,0.009792898,-0.023175174,-0.054823868,-0.056015506,0.008181917,0.05546792,-0.059377786,-0.0383012,-0.0021610088,0.04963091,0.03767556,-0.0484744,-0.004134033,-0.05271712,-0.009879703,0.05862991,-0.079021886,-0.04303016,0.10891635,0.04033692,0.030861529,0.011166062,-0.05498467,0.08432402,-0.077483416,-0.03833809,0.026314631,-0.06853341,0.012620055,0.033982594,0.07325394,0.006156089,0.05421811,-0.051492125,0.01576293,0.042286422,0.054808654,-0.1528559,-0.044079367,-0.019210182,0.058614124,-0.04502607,-0.016655272,0.11946967,0.0021856078,0.04632817,-0.028578116,-0.056810215,0.021531403,-0.070154965,0.045409683,0.0017786955,0.017566614,0.00043021332,-0.040686816,0.00092468294,-0.052184112,-0.008176592,-0.08929858,-0.043855485,0.035191912,0.018621879,-0.047621537,-0.035154097,-0.0052952985,-0.017859166,-6.4776696e-33,0.1253949,-0.0019234465,0.03431502,-0.09648181,-0.0029133202,0.10646332,0.07011193,-0.045869227,0.053452887,-0.016157132,0.11368343,0.025835637,0.0029249743,-0.089224085,0.047690015,-0.014440532,-0.046010476,0.092065856,0.002385976,-0.037322298,-0.013107425,0.060490157,-0.021052971,0.04269978,0.032736696,0.056931235,-0.041295603,0.07622004,0.011310742,0.03081432,-0.051973775,0.077607244,-0.036341622,0.002008682,0.004005116,0.0023382143,-0.102223486,-0.07173748,-0.0069459686,0.025375973,0.014807324,0.03659021,-0.025446318,0.0063106106,0.015609156,0.044591956,-0.11729284,-0.0017168012,-0.060160547,-0.01451047,-0.033533905,0.014407947,-0.07168104,0.061015505,0.021142691,0.0735941,0.017680852,0.06734958,0.02229416,0.017582633,-0.06258527,0.020053897,0.0099005485,0.039160978,0.09111301,-0.047998376,0.008435842,0.04164532,0.057674162,0.079559565,0.029538104,0.03496291,-0.003629904,-0.01873182,-0.041256018,0.029009854,-0.043061443,0.02869242,-0.03272275,-0.07256941,0.0012335717,0.030300776,0.02525865,-0.04994736,-0.045107543,0.060397863,-0.0024193218,0.030433109,-0.022029916,-0.0054766578,-0.00015531496,-0.07090697,-0.08565927,0.09505422,0.043832775,-6.0661975e-08,0.08352652,-0.04506809,0.039753683,-0.016430357,0.0740113,0.028057525,-0.023927974,0.029591646,-0.009051904,0.04313186,0.042372335,0.07399383,0.029552339,-0.062491413,-0.008534051,-0.019004183,-0.009086037,0.022335568,-0.0066066836,-0.011668438,0.028736196,-0.07268582,-0.07470968,0.07379424,0.06460855,-0.07594923,0.020321071,0.028960044,0.041773003,-0.037077952,-0.0398683,-0.033736203,0.07372775,-0.030663086,0.023335647,0.034648392,-0.08719117,-0.03407048,-0.04786714,0.08160875,0.040457007,-0.08384766,-0.030646367,0.023543436,0.020112656,0.015404296,0.04906966,-0.023854624,0.013885035,-0.075508386,0.007349605,0.011958905,-0.07756722,-0.04393698,-0.12617148,0.049707953,-0.09117324,-0.024694245,0.04320099,-0.083746016,0.069543205,-0.021482516,0.09501018,-0.021135753 +2.7.1.38,See comment on EC 2.7.1.37 protein kinase.,384,1.0,-0.07090397,-0.011237867,-0.042973015,0.04998001,0.060392365,-0.03205226,-0.008787449,0.07106821,0.015681887,0.01519086,0.051718816,-0.055038255,-0.05573368,0.011721412,0.0023207944,0.0034603926,-0.057285186,-0.014636258,-0.02208495,-0.041248303,-0.011162297,0.04251215,0.022411058,0.04689237,-0.023156628,-0.00836323,0.041990697,0.09954042,0.003751973,-0.14190437,-0.042627905,-0.023148831,0.056613185,0.039433908,-0.008530954,0.07946318,-0.043165334,-0.12390269,-0.060444333,-0.0019721286,0.11500097,-0.0063528153,0.057081696,-0.0545324,-0.015605923,0.02238957,0.027252762,-0.0180728,0.054866683,-0.015072897,-0.015513169,-0.050828688,-0.032037232,0.057305463,-0.015781097,0.015087675,-0.1367719,-0.0110755265,0.023677915,0.016521787,0.027293805,-0.018326396,0.06664097,0.03792338,0.022667265,-0.052370485,0.066669986,-0.07748078,-0.03151376,0.021619916,-0.0460584,-0.02983904,0.05195479,0.09143962,0.04479417,0.07271944,-0.08027857,-0.07775129,0.02030266,-0.06838252,-0.010213049,-0.042495705,0.012179843,0.0119042555,-0.019639187,-0.04542459,0.017518237,-0.0065896674,-0.07444239,0.038480293,0.0516325,-0.008178209,0.08137186,-0.011120288,-0.05876582,0.035459734,0.030818338,0.0924993,-0.036480736,-0.018014675,-0.04722888,0.10758484,-0.013475593,-0.007834763,0.032326177,-0.02268237,0.02854498,0.03341392,-0.010425688,-0.04533895,0.023179911,-0.040839907,0.07224503,0.015083019,0.0439721,0.084540814,0.016333645,0.011155425,0.03969705,0.03808816,0.036004398,-0.05730538,-0.011493473,0.03143205,-0.06817283,0.013715646,-0.07757754,-1.67568e-33,0.052110642,-0.031507835,0.10136491,0.0039615277,-0.051965814,-0.027557792,-0.08888844,-0.034169808,0.0023292813,-0.106904104,-0.038776822,-0.06486152,0.10189227,0.011364165,-0.04508205,-0.06048316,-0.012419181,0.02913913,-0.025146035,-0.03395636,0.06333098,-0.007895832,-0.05654934,-0.060726207,0.07326371,0.042233046,-0.019191757,-0.02720514,0.025887664,0.021298122,-0.123315334,0.0105474945,-0.025216212,0.07582026,-0.011989309,-0.0012271501,-0.0075064884,-0.0034326748,0.02172152,0.038955875,-0.0032188026,-0.006459061,-0.04232099,-0.08752098,0.022184294,-0.03604927,-0.012832752,0.10076561,0.03458261,0.022923296,0.034586478,-0.09761696,0.049851608,-0.02525028,0.0437225,-0.043078404,-0.07357935,-0.010290549,-0.0022805256,0.08523622,0.0021267717,0.06242163,-0.045579694,0.05427312,-0.03673579,0.041640285,-0.13408428,-0.079097494,-0.08369181,0.045266375,-0.014168725,-0.003733037,0.13644187,-0.049845293,-0.021064574,-0.03945335,-0.045474924,0.020952094,-0.054289408,0.110756,-0.054782417,-0.04632001,-0.05179926,-0.01008593,-0.040957164,-0.06149556,0.022356087,-0.07528816,-0.011927074,0.011108348,0.029408472,-0.04111582,-0.035959292,0.056990124,-0.0709283,-6.810269e-34,0.032789394,-0.01482358,0.034683414,0.036984682,-0.031358954,0.074503385,0.07135971,0.03211288,0.006058757,-0.005107186,0.10471533,-0.0071262075,0.012024551,-0.075345315,0.07656539,-0.015434044,-0.081819646,0.039514724,-0.020853912,0.023535796,-0.034770675,0.019427981,-0.010846719,0.1098458,0.04396368,0.017191362,-0.055057965,0.05035292,-0.014601544,0.03472066,-0.058576237,-0.013130991,-0.09162775,0.00818956,-0.024796342,-0.024680424,-0.03699971,-0.035990242,0.014907812,-0.08220599,0.006063838,0.036731657,-0.004031272,0.013422682,0.073650226,0.060384724,0.14150102,0.046840288,-0.018512134,-0.046631064,-0.036945373,0.0040923436,-0.023444217,0.047493774,-0.062695585,0.036208395,-0.030209487,0.09864406,0.05402542,0.01155493,-0.012304879,-0.06349113,0.056550924,0.030119406,0.088867955,-0.02027576,-0.05935793,0.08825252,0.025566345,0.02291448,0.1018938,0.005357936,0.008949227,0.025991788,-0.018804742,0.01898962,-0.049993217,-0.04452819,-0.022436287,-0.06570422,-0.06260544,0.052949693,-0.039070196,-0.06727199,0.036050215,0.0072920616,0.040691756,0.009471119,-0.03669232,0.025153372,-0.07830022,-0.04847864,-0.11774488,0.1035895,-0.0053757317,-1.972537e-08,0.06546486,-0.020317117,0.071547545,0.011912685,0.09398231,0.03739166,0.0036527526,0.1201677,0.03518152,0.045453433,0.010809671,0.023365887,0.065844975,-0.013192148,0.03755924,0.036777817,-0.019150512,0.033221126,-0.0041881073,-0.04797949,0.020650467,-0.11712893,-0.04938147,0.028748324,-0.013118022,-0.05566575,0.009285915,0.13370171,-0.0053367936,-0.1446397,0.0066798427,-0.05237816,0.044855442,0.010619872,0.01567208,0.059548523,-0.015775345,-0.021760574,-0.013781937,0.05468472,-0.0398449,-0.0025429244,-0.013815479,0.0046080244,-0.018990166,-0.009181901,0.07838423,0.003973301,-0.048498318,-0.056236718,-0.00026074395,-0.00047942146,-0.014855285,-0.081602775,-0.011767768,0.020161888,-0.031131364,-0.003402995,0.046579674,-0.049603455,0.02442368,-0.0189084,0.03696048,0.05430089 +2.7.1.40,"UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2.",384,1.0,-0.07325085,-0.042231716,-0.012067554,-0.061484333,0.0363391,0.022460759,0.07327559,0.07244274,0.009503937,0.039069407,0.008700803,-0.027217431,-0.06587285,0.11902579,0.0062817945,-0.004178565,0.00347955,-0.0014270251,0.0016090649,0.012791773,0.04347753,-0.028467685,-0.027984323,-0.031064527,0.026988085,0.01962424,0.008947654,-0.021606382,-0.0072412207,-0.033061385,-0.052826513,-0.0015854632,-0.08779335,-0.021242052,0.036777575,0.10397319,-0.012392569,-0.060172915,-0.007614268,0.03431283,0.022241533,-0.040811326,0.03297789,0.019943675,0.03667179,0.03257657,0.054939445,0.04835509,-0.03263289,-0.03489894,0.0508932,0.05282232,-0.0044142203,0.08511479,-0.01630345,0.04182614,-0.03286902,-0.039795425,-0.07881488,0.012039572,-0.07603041,0.012128528,0.018972222,-0.008262359,0.12697533,0.014489037,-0.007953443,0.00041172214,0.041411176,-0.044967625,-0.010748502,-0.024062783,0.041957054,0.03849957,0.038174644,0.09241127,-0.016792776,0.004207343,0.027001757,-0.011914727,0.022262478,0.08566342,0.10591057,0.049820423,0.06722141,-0.0071131936,-0.028749157,0.050103154,-0.0665034,0.05321028,-0.049168646,-0.00915294,0.08855417,0.027166005,-0.10986992,0.002559457,0.022403361,-0.03966933,-0.010795165,-0.040634286,-0.025802836,0.08096597,0.02340697,-0.04470064,-0.050186142,-0.006779401,-0.03797998,-0.018364744,0.03934883,0.003349776,-0.021767734,0.07043007,0.010064596,-0.0003745312,0.067647666,0.061303996,-0.08640578,-0.08709481,-0.06761988,-0.06726356,-0.008834862,-0.10071513,-0.03646323,0.045934632,-0.084258534,0.03419736,-0.08299731,2.1573515e-33,-0.0020996833,0.018904015,0.07231186,0.004924079,-0.07239243,0.018322967,-0.046975717,-0.10619901,0.02433891,-0.098243505,-0.045912318,-0.008677564,0.07081051,0.0611317,-0.10552348,-0.018981194,-0.10211027,0.031659268,0.06916032,-0.06444438,0.038734384,0.12292594,-0.003984422,-0.013870552,0.055880092,0.035630655,-0.1255196,0.01780109,0.0024700041,-0.001932984,0.030348726,-0.04110626,-0.03844464,0.06304651,-0.036156487,-0.0070577003,-0.043393552,-0.0767216,-0.061760448,0.050519273,0.038238294,-0.0012402588,0.016038094,0.040873956,0.055519063,-0.056819364,-0.043439705,-0.07238118,-0.06893405,0.045210592,-0.0047173705,-0.00870296,-0.034527123,-0.06314767,-0.03657219,-0.050324086,0.003308872,-0.064027436,-0.01386955,0.017167557,0.00497377,0.036521725,-0.033913348,-0.008062525,-0.07125482,0.034907475,-0.002552979,-0.14370102,0.0074884775,0.09352049,-0.078801766,0.005079271,0.060968593,0.03252693,0.058814812,-0.05794327,0.0349336,0.039113678,0.003963219,0.09708968,-0.012272669,-0.1249187,0.024403038,0.043200385,-0.02964417,-0.050992582,0.014725414,-0.09515723,0.027607901,-0.03538161,0.053110786,-0.025135016,0.028777499,-0.042381503,0.004733654,-3.7166336e-33,0.07189145,-0.086025335,0.0052946894,-0.02059514,0.004233529,0.018310715,0.051095396,-0.13260998,0.10258252,0.050270803,0.05267479,-0.03533936,0.062172353,-0.0499078,0.05853928,-0.05291025,0.03866698,0.051016595,-0.023977552,0.009750796,0.014437041,0.06273923,0.06919233,0.011734232,0.05320668,0.029776623,-0.06430442,-0.07002714,0.09454947,-0.026329026,-0.0005597743,0.07775614,-0.12283377,-0.080135636,0.0011020154,-0.04031535,-0.0140064955,-0.0032946852,-0.03420157,-0.05348163,0.043906983,0.006348776,0.08007984,0.06412766,-0.037363645,0.045582753,-0.010403105,0.0051001324,0.0019324323,0.0291775,0.026167039,0.022031954,-0.061842244,0.018681956,0.03785588,0.03515284,0.028202532,-0.018727131,0.025571097,-0.038365915,-0.049782824,-0.025552884,-0.008824005,0.002741952,0.02046419,-0.040446967,0.037796643,0.019303601,0.0031906879,0.06541597,0.074733324,0.026684644,0.07321727,-0.020645749,0.0054674204,-0.030730437,-0.124286056,-0.032053288,0.05138237,-0.0749041,-0.017889021,0.036869507,0.044345737,-0.035655458,0.08786754,-0.04445971,0.0043266066,0.012476058,0.024900738,0.015665742,-0.036021978,-0.024933167,0.013800015,0.01513621,0.044095248,-3.227834e-08,0.021120664,0.026174702,-0.019042943,-0.029595207,-0.05786027,-0.0056152027,-0.021687169,0.0734518,0.044255443,0.024892619,0.043934617,0.123247795,0.054168016,-0.051106818,0.02204536,-0.04408787,-0.010998653,-0.028157135,-0.03680635,-0.07685576,-0.09520238,-0.042404976,-0.04323058,0.060295105,0.013963166,0.0550535,0.041873835,0.030576926,0.04827777,-0.061963458,0.040916488,-0.038486294,-0.039758336,-0.028399875,0.03883144,0.040394504,0.063143745,-0.03996647,-0.047737755,0.028574217,-0.052615337,-0.08134103,-0.054221805,0.051423408,0.029789563,0.055691667,0.017864566,-0.031497758,-0.025607307,-0.07225686,0.027206484,-0.13358538,-0.044635,-0.08159914,-0.05000176,0.038669072,0.015928892,-0.0012214348,0.07683351,-0.075208515,-9.5162024e-05,0.07416214,0.11217384,-0.025366118 +2.7.1.45,"The enzyme shows no activity with 2-dehydro-3-deoxy-D-galactonate [1]. cf. EC 2.7.1.178, 2-dehydro-3-deoxyglucono/2-dehydro-3-deoxygalactonokinase.",384,1.0,-0.02880754,-0.14277485,-0.028682237,-0.049130414,0.032891337,-0.053149752,-0.10947512,0.013535256,0.0022241047,0.0045928154,0.021150798,-0.052505776,-0.06857046,0.032605365,-0.029021334,0.012753737,-0.058921497,-0.014234818,0.07888831,0.035639163,0.07546119,0.0043240557,0.03026062,0.04712975,0.13638961,0.020064445,0.04683864,-0.016307916,-0.053467024,-0.03373829,0.020622239,-0.06678599,0.042836368,-0.0029855454,0.05788718,0.11650953,-0.053864278,-0.030642884,-0.034582596,0.03273126,0.014032015,-0.018260399,-0.009701422,-0.03857126,-0.015269737,-0.044061624,-0.0936221,-0.020768596,0.031054871,-0.009730155,-0.03102562,-0.08434396,-0.014660088,-0.009645358,-0.003003552,0.03299037,0.013664631,0.0061791693,-0.037318047,0.0443597,0.078077264,0.050556693,0.025637446,-0.024084695,0.029251914,-0.020257965,0.031313915,-0.05926279,-0.026676625,-0.030245716,0.010433832,-0.05998886,-0.029952493,-0.0020287551,-0.021941194,0.0073706456,-0.04632437,-0.029268235,0.02531935,-0.07436389,0.022002626,-0.01709298,0.06427802,0.044113543,0.00352883,-0.0337308,-0.029130632,0.029393537,0.0044078557,0.0027474356,-9.548353e-05,0.005605183,-0.10534044,0.014069758,-0.006533598,0.056240562,0.024382057,0.047876496,-0.0098291775,-0.00864674,-0.0019379518,0.055697452,-0.047840245,-0.06042944,0.035070613,0.08496304,0.009864817,0.019634344,-0.014155405,-0.020918911,0.03994415,-0.039786603,0.09210335,0.027845884,-0.06700357,0.1370932,0.039132647,-0.047203805,-0.07835484,0.028346183,0.04970232,-0.027480515,0.0675413,0.0073951944,-0.016872441,0.073724344,-0.0008942063,-4.433845e-34,0.07076436,0.030048879,0.03158928,0.028768575,0.024907114,0.041067537,-0.08245588,0.02397184,-0.00708972,0.020399377,-0.07292663,0.018467348,0.08496296,-0.03822126,-0.0002464219,0.052128434,0.08089592,-0.051672608,0.006418083,-0.018162448,0.07717191,0.0013429949,-0.09391923,0.03339804,-0.009119783,0.049336318,0.016631858,-0.014408144,0.13714573,0.006327196,-0.040176354,-0.14014061,-0.05527595,0.0053433254,0.0452439,-0.00626233,-0.09136734,-0.04304758,0.00023915179,-0.04623958,0.01677434,-0.039817967,-0.014349602,-0.07723944,-0.0066845454,-0.008743163,0.03032736,0.08747164,0.010560002,0.059896577,0.1220142,-0.011677194,0.0038049277,-0.03527741,-0.041579723,0.054658014,-0.02757919,0.034559783,0.084146835,0.03887546,0.026255643,0.037584387,-0.02516548,0.0026937407,-0.0039093285,0.04411986,-0.039294392,0.003773066,-0.060374875,-0.0013463493,-0.062232185,-0.065685496,0.046834107,0.024562072,0.039910555,-0.036642898,-0.010284114,-0.016204229,0.03018215,-0.058401976,0.0044346265,-0.013350012,0.016098587,0.021563407,-0.022589874,0.03578408,-0.079714514,-0.0072277007,-0.022176195,0.077901386,-0.0020256822,-0.015223399,-0.043109644,0.036913775,-0.0018326706,-1.9461038e-33,0.004887622,-0.07623708,0.039448597,-0.103105225,-0.027606446,0.13309348,0.02716476,0.01507925,0.11503635,-0.04677057,0.12883715,0.010763586,-0.05425707,-0.10061844,0.0135103045,0.0813374,-0.03718212,0.065966316,-0.06535723,0.016029341,0.07719571,0.1185035,-0.05490161,0.10050151,-0.0018932219,0.012301773,0.0061394074,0.05548023,0.051397353,0.0979198,0.05544984,0.016709832,-0.0011052649,-0.06485719,-0.06633368,0.051815454,-0.030240914,-0.026189888,-0.054232165,0.012465958,-0.07185066,0.032789532,0.044521358,0.12056802,0.0752463,0.12592325,-0.06775736,-0.010465625,0.0016784278,-0.012374659,-0.012341721,-0.03778445,-0.059261806,0.036255125,0.01685949,0.045658883,0.021893617,0.01111531,-0.049034163,-0.038539503,-0.022214567,-0.028441086,0.03473226,-0.050993692,0.036021646,0.03916849,-0.034192573,0.093751855,0.048387635,-0.044750515,0.07136577,0.022138502,-0.065114684,0.015137724,-0.0061571053,0.06005635,-0.06953936,-0.06219357,-0.006815195,-0.098554745,0.044905055,0.061537884,0.017282728,-0.054334,-0.011637533,-0.07022726,0.033519104,0.08202457,-0.061851732,0.010597811,-0.053134743,0.029270394,-0.06714835,0.022781104,0.08745948,-3.8647986e-08,0.04604634,0.04227825,0.07432221,-0.105922945,-0.0026707782,-0.024275534,0.036332406,0.04596376,0.005033084,-0.044802498,-0.035997503,0.04224782,-0.06386871,-0.032063693,-0.016124593,-0.0033893085,0.028328026,0.047620036,-0.06349323,-0.025360085,-0.01934552,0.01480703,-0.08838068,-0.021342097,-0.029028982,-0.054015957,0.036974348,0.041487154,-0.0043567154,-0.06090184,0.03157277,0.046845824,0.030033903,-0.005793465,-0.119002536,-0.00017735994,-0.06185415,0.009076952,-0.033975776,0.0072521633,-0.03009476,-0.037218284,-0.0016923648,-0.014443503,-0.0931331,0.03336413,0.0020103594,-0.0025973888,0.03161529,0.033430725,0.053751763,-0.017464876,-0.07996577,-0.05135318,-0.06753194,0.025208434,-0.018814454,-0.06878892,-0.029803667,-0.12698811,0.015333667,-0.09658497,0.111086875,-0.008065508 +2.7.1.48,"The enzyme, found in prokaryotes and eukaryotes, phosphorylates both uridine and cytidine to their monophosphate forms. The enzyme from Escherichia coli prefers GTP to ATP. The human enzyme also catalyses the phosphorylation of several cytotoxic ribonucleoside analogs. cf. EC 2.7.1.213, cytidine kinase.",384,0.99999994,-0.031735912,0.01006134,-0.0779846,-0.06153138,-0.03153728,0.03021319,-0.021619208,0.08271155,0.08612664,0.023810465,-0.0014127373,0.026636384,0.012495217,0.109362125,-0.054414608,-0.033318818,-0.0524074,0.07795303,0.053749107,-0.057042915,0.09188146,0.043772217,-0.023440324,0.025129074,-0.024760501,-0.061428256,0.05906456,-0.011620775,-0.07045939,0.0032907939,-0.07069665,-0.06402269,0.019154195,-0.035602137,0.05615905,0.09777709,-0.052830916,-0.083889335,0.060530476,-0.0009628759,0.016246399,0.03866332,-0.02369318,0.036197938,0.004418567,0.035551168,0.020825395,0.05071974,0.009476486,0.0024092179,-0.010945072,0.02834119,-0.007248455,-0.011253938,0.044663373,0.050553195,-0.11634405,-0.02651548,0.0022706147,0.011628964,-0.03673009,-0.02740011,0.025366534,0.005335473,0.09046538,-0.060289413,-0.019799141,0.0008024871,-0.007745813,-0.05665103,-0.04594438,-0.053997137,-0.024519866,0.06861379,-0.01817313,-0.0018278118,-0.038935326,0.010176676,-0.035019986,-0.034976814,0.045548577,-0.06926895,0.013161203,0.0074247103,0.06288712,0.031503756,0.0068182326,0.053168017,0.02986522,0.019849954,0.0584213,0.028861823,0.04206122,-0.07647009,-0.03789472,-0.011095456,-0.0068731904,0.048109714,-0.03706977,-0.05146765,0.06689717,0.055106837,0.008234648,-0.023806846,0.04807099,0.058241636,0.047311574,0.08387527,-0.02903704,-0.020670779,-0.02132309,-0.005406496,-0.001643253,-0.02052819,0.005697125,0.09896163,0.027174791,-0.046908654,-0.058986966,-0.03573919,-0.027942037,-0.09324036,-0.018520499,0.07162378,-0.064940296,0.07943498,-0.09053984,3.971483e-33,0.014946907,0.029453753,0.049752925,-0.049797162,0.024982981,0.05337361,0.03581352,-0.033728264,0.0461948,-0.17039205,-0.11331927,-0.07523096,0.034288384,-0.029198293,-0.08941767,-0.014983452,-0.092458285,0.05824902,0.0692573,-0.009348876,0.0698273,0.03710592,0.04471287,-0.035651203,0.0025453905,0.021317065,-0.07213861,-0.068918265,0.02596639,-0.009978049,-0.034448653,-0.053985704,-0.10184547,0.049981385,0.016857613,-0.04784344,-0.064287886,-0.049665682,0.004593453,0.038953245,-0.0911982,-0.04649427,0.016693598,-0.023854395,0.048883285,-0.036202863,-0.048527513,0.02529834,-0.0688995,0.051377863,0.057826668,-0.0546846,0.050484326,-0.039923456,-0.050771564,0.013682483,-0.007584262,-0.045008335,0.013885689,0.0480866,0.039803255,0.07657498,-0.033830274,0.048367195,0.006975558,0.025151774,-0.094986506,-0.12994479,0.02640327,0.17293464,-0.038645416,-0.010491836,0.05292115,-0.0006187753,0.012195019,-0.012682413,-0.08627354,0.020101588,-0.036565468,0.057696767,-0.004002026,-0.0379125,-0.0049738972,0.048882227,0.026149586,-0.026560344,0.069006115,-0.082188755,-0.018575639,0.04031648,0.06424299,-0.043432266,-0.06491158,0.06380623,0.027225034,-4.7815136e-33,0.15295061,-0.08401054,0.12226063,-0.066620246,-0.048260577,0.017934123,-0.019436557,-0.1280271,0.06871603,-0.026778257,0.00563813,-0.015725853,0.0071968804,-0.034465246,-0.03293887,-0.038677786,0.05438321,0.10762257,-0.020726884,-0.00035150722,-0.05202832,0.0041168635,0.00905377,0.023757339,0.0486837,-0.038434133,-0.017622024,-0.019381601,0.059055958,-0.043870553,-0.039984282,0.074775845,-0.06814901,-0.103454754,0.04515706,0.06440011,-0.047326915,0.009586554,0.06701662,-0.012028059,0.0005651412,0.054047454,0.011256763,0.026604831,0.031216793,0.06773041,-0.037149888,0.0034066471,-0.085790105,-0.05232815,0.06740174,-0.01528229,0.0041138637,0.052002568,0.06957496,0.04137189,0.019483438,0.07697466,0.0048091672,0.007958467,-0.050134767,-0.039060682,-0.040612694,-0.0009132826,0.018965626,-0.0047606714,-0.018509815,0.018605404,-0.005399016,0.03422072,0.018956859,-0.007919007,0.02233431,0.02449084,-0.034417994,-0.025645362,-0.053666934,-0.04560389,0.046024855,-0.049520038,-0.022152215,0.031555194,-0.036174435,-0.017638303,0.0074889874,-0.0412897,0.043799665,0.11744318,0.0044922596,-0.021503782,-0.01748554,-0.048647884,-0.02011624,0.04314657,0.029658858,-3.8464794e-08,0.040534843,0.012435841,-0.022052543,-0.10258225,-0.016390696,0.048008446,0.031440705,0.049217504,0.03196935,-0.03275499,0.028444534,0.03341638,0.054856017,-0.018801784,0.036213078,0.06523223,-0.08811131,0.0037428816,0.024910616,0.034476265,0.012404835,-0.004578783,-0.14473295,0.09127674,0.025855687,-0.03571225,0.04526238,0.015499337,-0.01640651,-0.028246269,0.07466547,-0.07411475,0.031548418,-0.039289087,-0.00021439587,0.03062554,-0.027699571,-0.012332294,0.014078823,0.007966473,-0.056423414,-0.038826615,-0.045840953,0.0027311328,0.0064722435,0.019813107,0.018932339,0.008297481,-0.05316134,0.0014718019,0.026302803,-0.005189791,-0.0054985,-0.116588905,-0.005951856,-0.0054586083,0.008629796,-0.10658288,-0.006607158,-0.05869874,0.08059709,0.055649262,0.17935675,0.018720658 +2.7.1.49,"CTP, UTP and GTP can act as donors. ",384,1.0,-0.10459711,-0.004552733,-0.005825932,-0.08481254,-0.058544125,0.047161605,0.044864487,0.013399599,-0.017047254,0.0151082855,0.02328153,0.0033649476,-0.02481414,0.05906083,-0.009338886,-0.023134919,0.036743876,-0.020677272,0.049489982,0.052203104,-0.02641074,-0.05576669,-0.05902387,-0.020839429,0.08159346,-0.030637078,-0.005532593,-0.0077856444,0.036377724,-0.022142868,-0.0476657,-0.005658997,-0.040281735,0.025568953,0.014336809,0.10261772,0.016004307,0.0066767656,-0.05076801,0.024659643,0.04115901,-0.037773084,0.008633998,0.063389026,0.05113015,0.0038080367,0.05883129,0.043071926,-0.07374771,-0.00881416,0.10058643,0.05160575,0.021681456,0.07595995,-0.068402655,0.018129159,-0.034685627,-0.06306628,-0.052967414,-0.032729305,-0.03290229,0.060163647,-0.028548755,-0.021616418,0.07720574,0.08587286,-0.0027354269,0.024859903,0.02135408,-0.088680655,0.011538296,-0.02635546,0.01474431,0.037607014,-0.0035153169,0.08665679,0.015120068,0.04571685,0.028386422,0.008390232,0.012478692,0.08571658,0.0078375805,-0.041348595,0.07707723,-0.0056203566,-0.051331878,0.009195213,-0.032618176,0.06467056,-0.05111645,0.03056415,0.09849252,-0.009515599,-0.06683947,-0.031967696,-0.027768517,-0.04037847,-0.02176313,-0.013715058,-0.05327402,0.103181705,0.061070915,-0.024730202,-0.02857639,-0.06849987,-0.06700704,-0.04683767,0.055148516,-0.004565243,-0.010967359,0.07385578,0.012650456,-0.0029500027,0.02597867,0.058086224,-0.18192755,-0.020253114,0.012178076,-0.045346923,-0.025221609,-0.017920231,-0.0853952,-0.007474748,-0.036346644,-0.022653235,-0.082373664,-2.5700026e-34,-0.05294416,0.069298096,0.06048835,0.023354923,-0.034849625,0.031223578,-0.037832946,-0.044974007,-0.049351003,-0.059280213,-0.04983258,0.029967377,0.06665139,0.02636092,-0.05956575,0.033057567,-0.12004457,0.039361678,0.055271592,-0.011091726,0.04964707,0.11870404,0.01600608,0.016696053,0.107574336,-0.0015133404,-0.13451016,-0.01967855,0.09653222,0.009419206,-0.005351461,0.019164514,0.012863683,0.0585866,-0.040642906,0.033669032,-0.0005424756,-0.07826248,-0.022855943,0.0035848094,0.02020465,0.017430622,0.056611314,0.041967448,0.022834888,-0.04187216,0.042647608,-0.11523773,-0.106853716,0.0547257,-0.0067002554,0.0111952135,-0.09822208,-0.09270507,-0.02108828,-0.08955235,0.0007144995,0.044510543,-0.0141164465,-0.0111082755,0.05099104,0.017496536,-0.0009788895,0.00365219,-0.1301208,-0.002385483,0.01501125,-0.11312624,0.055181958,0.04383024,-0.04273069,0.057405807,0.012020551,0.045515403,-0.0034845558,-0.043285057,0.021321772,0.04243714,0.084204085,0.055276662,-0.074830815,-0.08298078,0.014009615,0.053715628,0.05869753,0.0059196944,0.05551792,-0.05589742,0.036051095,-0.0648962,-0.027741503,0.019279568,0.021014554,-0.045593057,0.03272329,-1.3925326e-33,0.014150855,-0.099965125,-0.02035484,0.025850018,0.022143083,-0.03919411,0.028444355,-0.15200397,0.0737515,0.05973517,0.023376124,-0.04434179,0.08894816,0.05308025,0.042357106,-0.0728723,0.023533504,-0.01017027,-0.052639138,-0.019725535,0.03371357,0.08175866,0.039709404,0.024444537,0.037509028,0.025926238,-0.07705174,-0.0357191,0.0977214,-0.032538272,-0.01500186,0.037471667,-0.13058633,-0.043327127,-0.07485652,0.030723799,0.020671198,0.047768317,-0.021675179,-0.04627495,0.10515245,-0.06016187,0.01489078,0.07318203,-0.08544549,0.005425353,0.065327555,-0.03715423,0.02995179,0.00353743,0.011829289,0.009166316,-0.019477498,0.030402517,-0.027626788,0.04389093,0.057746854,-0.065550424,0.014981179,-0.034347676,0.03229907,0.016042987,-0.02522915,0.031726863,0.015636003,-0.04891312,0.07051439,0.03175315,-0.0013651144,0.06697808,0.05633098,-0.03991355,0.050562464,-0.061882183,-0.030128008,-0.005787017,-0.06975258,0.030674618,0.044742685,-0.13063759,-0.004902562,-0.053503364,0.0577133,0.06321379,0.055842824,-0.026203603,0.060969792,-0.018750465,0.074363865,0.030103184,-0.06316493,-0.00599162,0.04050241,0.017121552,-0.0050455877,-2.1169344e-08,0.023675876,0.052379847,-0.08162212,0.012811567,-0.010631306,-0.013672245,-0.08338502,0.036152523,0.0094061475,0.06849341,0.026981307,0.053535644,-0.06011929,-0.07495148,0.040846907,-0.0045736614,0.013408861,-0.025159193,-0.031566836,-0.0444928,-0.13290673,0.022847086,-0.03077985,0.06928331,-0.05240829,0.09341835,0.0144384075,0.013450295,0.0686032,-0.017368775,-0.011536923,-0.0076063015,-0.09627985,0.027961906,0.016142815,0.005361715,0.038030278,-0.022245433,-0.034911785,-0.028688451,0.00058269285,-0.06599065,-0.087514,0.0434816,-0.022972153,0.027839493,-0.00982315,-0.08163542,0.0074259117,-0.021554152,0.025311595,-0.039242554,0.013725212,-0.0078572435,0.03906263,0.019997513,0.03371943,0.00074473897,0.05575805,-0.04640263,-0.03412835,0.026874974,0.074411064,-0.025925234 +2.7.1.52,"Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.",384,1.0,0.0032326097,-0.08947806,-0.028224938,0.036444735,0.04380177,0.00803556,-0.013956764,0.00443094,0.03402178,0.023818862,0.03738045,0.032444376,0.0004249369,0.03002231,-0.021394754,0.0016585052,-0.012871556,0.06724903,-0.09641064,-0.025888218,0.08415856,0.014639899,-0.017181307,-0.038233154,-0.004350332,-0.08093157,0.0003436049,-0.014249266,-0.029410621,-0.09979005,-0.03643109,0.06436018,0.03823036,-0.043695055,-0.020646282,0.11091576,-0.017979702,0.009613554,0.03837298,-0.009865503,-0.027125094,-0.1073264,0.07564436,-0.067823924,-0.05139096,-0.088241175,0.0053320797,0.012523755,0.06520319,0.03130699,-0.03471897,-0.029956512,-0.060459185,0.035514887,0.004906685,0.024601376,-0.03741218,0.0397416,-0.052319154,0.0026152774,-0.026355982,0.07860426,-0.049980838,0.040685132,0.027981916,-0.082369305,0.09186063,-0.044315334,0.011766122,0.02367859,0.036139548,-0.042576563,-0.02185912,-0.017335981,0.07647057,0.08912206,0.040202945,-0.069448896,-0.001563659,-0.012822348,0.09503272,0.03908633,0.05447261,0.061894998,-0.0054720747,-0.02032317,-0.034635082,-0.04364734,0.041077293,0.059821736,0.0702954,0.01519821,-0.05677161,0.0074565574,0.010992884,0.0069440943,-0.001314951,0.025706295,0.006628547,-0.008678749,-0.069324255,0.040360715,-0.01682767,-0.060794808,-0.0401668,-0.009513492,-0.029926261,0.068014205,-2.6952373e-05,-0.08187284,0.054021493,-0.0041406993,0.07952303,0.02141163,-0.0052882107,0.06105251,0.050020047,-0.1477625,-0.04960278,-0.014490645,0.019530537,0.0015903425,0.03913149,0.035121944,-0.06750405,0.02286208,-0.0509678,2.4045064e-33,0.027422303,0.02773806,0.026591979,0.04712299,-0.023509266,-0.041227803,-0.030591434,-0.10679543,-0.03703904,-0.04569862,-0.10047928,0.009170332,0.01496568,0.047028888,-0.06427793,-0.049855378,0.045824986,0.0017228343,0.014246514,-0.03525907,0.033221245,0.04863625,0.012646558,-0.08680154,0.05441501,0.11415298,0.064368285,0.014019115,0.005318181,0.012507487,-0.0066127745,-0.1152571,-0.04646092,0.050525375,-0.009893375,0.041291643,-0.09436204,-0.047172036,-0.01540399,-0.05262326,0.015063476,0.057142604,-0.053867184,-0.01905886,0.056744624,-0.024910126,-0.056211606,0.081585534,-0.02240936,0.13428482,0.13994911,0.029271726,0.0666694,-0.04770457,-0.091358855,-0.018741915,-0.053444117,-0.007276598,-0.013892009,0.12671262,-0.008442004,0.043746464,-0.025599563,0.1130456,0.03882138,-0.004523801,-0.08300398,-0.04505014,0.0074834507,0.052370057,-0.07658393,-0.06353972,0.11839534,-0.028479833,0.065409765,-0.04061625,-0.028151957,-0.06419318,-0.015189059,0.022021458,0.018917803,-0.07399969,-0.053072236,0.026136057,-0.088059746,0.010028237,-0.021836122,-0.039140347,-0.007462453,0.0091039,-0.019869868,-0.023261514,-0.013654461,0.049291894,0.07915893,-4.3791235e-33,0.039931744,-0.054935966,0.05552341,-0.031108024,-0.067083694,0.033430282,0.06471486,-0.018584158,0.018150855,-0.021244513,0.0007983823,-0.056322314,0.00032410948,-0.10150249,-0.050794188,-0.038071178,-0.015012113,0.021630486,-0.018015776,0.029179167,-0.053369746,0.08050928,0.04661666,0.042303845,0.09482035,-0.008100888,-0.020659342,0.05954226,-0.01763704,0.08612192,0.07473916,0.061060544,-0.037478656,-0.051857527,-0.037452217,0.0465206,-0.027544128,-0.019208511,0.051682755,0.030866733,-0.030307855,0.060737964,0.09865495,0.03623623,0.031734347,0.088887975,-0.04783259,-0.01977708,0.061102513,-0.041585956,0.0130906645,0.0012424657,-0.036279496,0.006796738,0.0711237,0.06363975,0.008797347,0.0049844356,-0.055758566,-0.033986356,-0.090623625,-0.063123435,0.016843256,-0.04304611,0.07745873,0.01891571,0.005403123,0.019935949,0.015163558,0.036923956,0.11531969,0.09402991,0.025702827,-0.0022640557,0.0010167444,0.01750545,-0.088102624,-0.0634475,-0.01195464,0.029548757,-0.03966983,0.011857457,-0.022650968,-0.046512045,0.0354386,-0.13740575,-0.020122223,0.05214625,0.02687428,-0.0036783572,-0.052043837,-0.10192383,-0.03477848,-0.010401959,-0.001168999,-3.71913e-08,0.012375435,-0.05589017,-0.024488635,-0.02303487,0.019280938,0.043932207,-0.024068186,0.05383178,0.0139056,0.05372305,-0.04815654,0.098160215,0.016750664,0.03266343,0.031077275,-0.024803188,-0.02006051,0.044793647,-0.054279823,-0.040316015,-0.043212015,-0.04371455,-0.11147676,0.045018304,0.051058006,-0.04147387,0.004219941,0.049612068,-0.0058981734,-0.0041010138,0.041121066,-0.029267788,-0.038329642,-0.0248709,-0.09432575,0.01866503,-0.054576673,-0.010533111,-0.05518939,0.0075532175,0.007912733,0.03481303,0.029213114,0.023222229,-0.0736388,-0.07056718,-0.07278525,0.057469614,-0.03679276,0.026158549,0.07463107,-0.050323717,-0.055361565,-0.053460475,-0.055111554,0.013665384,0.028075553,0.0020741732,0.04345847,-0.052663285,-0.007420703,0.01917862,0.1408043,-0.101991616 +2.7.1.56,"ITP, GTP or UTP can replace ATP. ",384,1.0,-0.07861262,0.052165855,0.0474732,-0.06419661,-0.030489428,-0.002992151,0.0037491738,0.05822968,0.018650413,0.00081785413,-0.021008642,0.04716223,-0.050570466,0.10775948,0.004530213,-0.084630765,0.066236585,0.022550162,0.092811026,-0.016085675,0.030130101,0.0142444,-0.037586655,-0.020321745,0.000302197,0.040831275,0.025960252,0.068617776,-0.04459657,-0.07219493,-0.13282713,0.0020854066,-0.028710347,-0.06254946,-0.019635433,0.070203066,-0.047453113,-0.00026832198,0.06450175,-0.065306135,0.037004072,-0.00040102456,-0.060701035,0.07030263,0.025317663,0.0409321,0.0018628249,0.030940922,0.0014021704,-0.05877192,0.031595808,0.02047684,0.053178146,0.021043047,0.014892057,-0.01846374,-0.07639227,-0.018631302,-0.068488285,0.00015496748,-0.057177722,-0.0042531528,-0.029479576,0.04929429,0.07878917,0.03875213,0.03186203,0.03172632,0.036695994,-0.0022287958,-0.11049146,-0.016313972,-0.042120185,0.096116215,0.018197365,0.07630816,-0.0017935961,-0.012465945,0.07093384,0.020159017,0.00895326,0.058178212,0.038442872,-0.017177178,0.124379456,-0.058926694,-0.017215315,0.030853372,-0.059916828,-0.012336907,0.0022631371,0.035042215,0.08160719,0.021525739,-0.039666377,0.035733692,-0.028405923,-0.040191032,-0.06353096,-0.0091709895,0.030743962,0.092524074,0.03907164,-0.029793913,-0.03339466,-0.0020762084,-0.017920982,0.027628677,0.051055804,-0.01555832,0.024331955,0.03108765,-0.045345645,-0.029127752,-0.0007310137,0.06093512,-0.09268449,-0.0026153752,-0.012512273,0.027419169,-0.09433196,-0.1336803,-0.056479286,0.04960646,-0.07954356,0.040754575,0.007143742,-9.6177e-34,-0.03422825,-0.0067955055,0.012055332,-0.017376442,-0.021694405,-0.006894843,-0.029791102,-0.01726368,-0.013665895,-0.13810971,-0.05633455,-0.031705264,-0.008040188,-0.027289607,-0.013777512,-0.03894924,-0.114879645,0.09498545,0.11132851,-0.0785084,0.0024306048,0.07211879,0.017087687,-0.08663797,0.101438984,0.0528415,-0.050895635,-0.10316911,0.04649222,0.00018885745,0.01841564,-0.043716937,-0.108896494,0.06746477,-0.071346715,0.0038741105,-0.05921818,-0.0721926,0.080812156,-0.025303276,-0.03896703,0.06905686,0.010843352,0.0138034895,0.038622618,-0.057615094,-0.018937701,-0.018628784,-0.101121254,-0.041386135,0.040779863,-0.017839096,0.0072154105,-0.05644852,-0.034441262,-0.009409423,0.029927103,0.052538082,0.034496326,0.1166046,0.10598482,0.084959,-0.022271689,0.03980896,0.055874243,0.05162161,-0.07400762,-0.12762965,-0.0050406153,0.11423766,-0.04521679,-0.03050072,0.07058272,0.039898086,-0.0045733154,-0.023292614,-0.009958548,0.029643122,-0.053745996,0.062221646,-0.03186561,-0.097526975,-0.050609127,0.023187894,-0.017917326,-0.008996694,0.0478969,-0.05619706,0.020758694,0.027589126,0.13920654,-0.008688438,-0.020128518,0.07774394,0.033922434,-8.2057335e-35,0.022263091,-0.08399864,0.05773255,0.03533181,-0.013477471,0.0072086654,0.11200776,-0.09821908,0.016201809,0.045759115,0.0334076,-0.049492784,-0.013548365,-0.07118927,-0.0037376524,-0.0062769535,0.0059952424,-0.01625607,-0.054739814,0.054687086,-0.001670009,0.10231487,0.06116644,0.029272657,0.0063605607,0.041494437,0.015144464,0.0093314275,0.064759016,0.011823824,0.017556129,0.032907024,-0.10392518,-0.019258926,0.03211045,-0.0023184768,0.0049909297,0.05234103,-0.03133244,0.019671798,0.093346044,0.021678463,-0.0066756485,0.040579945,0.027124567,0.08093637,-0.035655238,0.0058090263,-0.01705753,-0.01374932,0.07152825,0.005529383,-0.09999465,0.025020143,0.026066868,-0.0055075563,0.042617645,-0.045462668,-0.06655183,-0.04978607,-0.057825897,-0.026808335,0.04170404,-0.038499728,0.045693215,0.049385104,-0.024887621,-0.05963318,-0.043761216,0.034833357,0.0597372,0.0041320757,0.036832996,-0.064330325,0.01833563,0.070831984,-0.0073475665,-0.0068379445,-0.027662216,-0.02917652,-0.08235873,0.08067729,-0.045025803,-0.020730417,0.035332482,-0.03643622,0.0136867305,0.055610064,0.018696442,-0.005370052,0.013231912,0.02285339,-0.0068187653,0.024119321,-0.0013731131,-1.7213102e-08,0.015716026,-0.046516616,0.080136456,0.003225991,-0.022128895,-0.02570505,-0.022214381,0.042302858,0.09290694,0.0012330206,0.022149805,0.029314386,0.045676403,-0.046285853,0.08133428,0.022233184,-0.048760712,0.03291235,-0.029056512,-0.06963128,-0.120575346,-0.016808655,-0.036589697,0.08961886,0.057638977,0.017734583,0.013290048,-0.02620524,0.08430258,-0.13013099,0.010800201,-0.06591372,0.04757796,0.048722498,0.022401849,0.011586188,0.0045407135,-0.018594455,-0.051324464,0.024954464,-0.072541006,-0.083849736,-0.064448655,0.046408676,0.030749762,0.0016269896,0.015204119,0.011246498,-0.061791547,-0.045163147,-0.0047125877,-0.025554383,-0.0030173443,-0.056604866,0.0022246724,0.015032587,-0.013425691,-0.065671936,-0.022672806,-0.021292739,0.033054586,-0.033276703,0.09187862,0.0037107863 +2.7.1.59,The bacterial enzyme also acts on D-glucose.,384,1.0,-0.124416836,-0.04481381,-0.0837698,0.008475566,0.006206239,-0.007084199,0.018389413,0.041681986,0.044400413,0.06370141,-0.039395597,0.01228196,-0.064012535,0.10554548,0.010490021,0.0026894144,-0.048440743,0.014235658,0.04833235,-0.013426025,0.11438735,0.056481168,0.028529895,-0.046523985,0.07446114,-0.014252748,0.11148689,0.013756505,-0.054751072,-0.026283948,-0.037343137,-0.022161392,0.05565784,-0.009511906,0.07513977,0.14338052,-0.006850904,0.0007522841,0.04163232,-0.05142357,0.0446035,0.015954822,0.04868374,0.020438869,-0.009694814,0.01991255,-0.05133205,0.09707353,0.031038297,-0.043117817,-0.07648027,-0.024650067,-0.016088847,0.03553196,0.05030849,0.051227596,-0.020890893,0.0004398351,-0.027299969,-0.10189826,-0.029727,0.02625989,0.045376107,0.053222023,0.018081686,-0.1004846,0.016781915,-0.061218213,-0.02043403,-0.041903276,-0.058872983,-0.054073084,-0.005770557,0.014217863,0.030362656,-0.059809875,-0.031887744,-0.06099092,0.02342223,-0.034813557,0.05207304,-0.01166205,0.07523331,0.07706579,-0.03148904,-0.059068155,0.090196714,-0.02120971,0.0044948123,-4.751893e-05,-0.023725342,-0.06190544,-0.06405199,-0.017741302,-0.09991158,-0.058542803,0.0039428286,-0.0020872478,0.023528613,-0.030311488,-0.03641664,0.027642865,-0.0064884783,-0.026797894,-0.06924159,0.014743202,0.039774984,0.090275496,0.0148818,0.0070998254,0.04375825,0.050113864,0.057136033,0.05667145,-0.11206343,0.012435768,0.06493556,-0.064480096,-0.08650157,0.023702864,-0.04796747,-0.08758463,0.052831978,-0.007065739,-0.06467709,0.10473254,-0.025950227,-4.9109017e-33,0.058151517,-0.1179225,-0.028725645,-0.10506003,0.02727238,-0.0017176967,-0.06806073,0.020291876,-0.007549402,0.0025579385,-0.089330815,-0.07816085,0.054127373,0.07118903,-0.019695671,0.041322388,-0.004168252,-0.010679765,0.047421426,0.019476613,0.039382473,0.07710085,0.01708841,-0.00024251232,0.033688404,0.026585583,-0.011879803,0.08532673,0.047278114,-0.0040776846,-0.004117909,-0.09060794,-0.015493795,0.03339251,0.08235004,0.098443255,-0.07207425,0.03911201,0.00924999,0.031400986,0.023528188,-0.004053011,0.001199965,-0.056837656,-0.021574078,0.031968277,-0.035630386,0.05125797,0.02869746,0.09641911,0.08973759,-0.05440928,0.04088148,-0.030909915,-0.02531412,0.04072264,-0.0056309924,-0.014994904,0.01108206,0.0076093525,-0.03893685,0.043263875,-0.050764892,0.037094407,0.03729823,0.003459953,-0.03738832,-0.059487842,-0.03380525,0.02437808,-0.12435994,-0.005779659,0.0650812,-0.019766668,-0.053924162,-0.025603399,-0.0443343,-0.02343642,0.045065027,-0.05191517,0.034256637,-0.056072123,0.00430609,-0.055457514,-0.062401745,0.04200862,-0.085196465,-0.085425444,-0.054011144,-0.03380486,0.0439077,-0.029861886,-0.093906835,0.0133877555,0.040825624,2.400416e-34,0.041583452,-0.08404949,0.06721519,-0.04160525,-0.02320434,0.066181876,0.010263343,-0.052009188,0.016163122,-0.016863007,0.011974969,0.050362945,-0.071309455,0.022067612,0.012357993,0.05173571,-0.068561256,0.041438617,-0.08757574,-0.039239388,-0.023684733,0.12568647,0.0071289856,-0.008415341,0.03232751,0.0038953717,0.007156869,0.10476426,0.008369577,-0.0048580864,0.060891453,-0.021654963,-0.063158534,-0.04415645,-0.023639742,0.032605823,-0.03622352,-0.03812383,-0.040970948,-0.025619613,0.03628395,0.046732582,0.049205747,0.04444483,0.06164272,0.032539126,-0.031116996,-0.012990264,-0.026641138,-0.05427015,-0.026632315,-0.012042819,0.035506304,-0.025106343,0.0058777654,0.06585135,0.04004072,0.0417241,-0.0453735,-0.014554025,-0.013523195,-0.10430206,0.070569135,-0.007412298,0.01574805,0.016972,0.009375201,0.04039835,0.11461497,0.004688797,0.055418603,0.026539238,-0.04118176,0.0139278285,-0.11185809,-0.034044307,-0.07630673,-0.008342349,0.06704722,0.0010626167,-0.020850252,0.034203965,-0.028927693,-0.053939823,-0.03210289,-0.09928694,0.0064692893,0.03893622,-0.0011834026,0.07161544,-0.05601119,0.016260467,0.02217884,-0.039261956,0.056495424,-1.785559e-08,0.05120485,-0.035557013,0.041786954,0.020387525,0.018506719,-0.0024904865,0.00061686325,0.047885194,0.07852937,-0.05027666,-0.023432989,0.13884634,-0.026387941,-0.002744096,0.04497134,0.0210802,-0.08095209,-0.028754517,-0.060541715,0.012164652,-0.08306358,-0.040936064,-0.12583554,0.088416226,0.013680999,-0.088486075,0.045622583,0.028837545,-0.051198047,0.007999951,-0.0014997056,0.056614872,0.008180652,-0.031784255,-0.07581228,-0.0722457,-0.02151275,-0.04771783,0.0044780755,0.03437784,0.095785536,-0.0043087504,-0.057398297,0.039691303,-0.03694818,0.065879494,-0.030865887,-0.0015320028,-0.051947165,0.00914253,0.024666931,-0.001191609,-0.081080206,0.014290664,-0.08443141,0.037000597,-0.04840007,-0.04423831,-0.0061725,0.0035266904,0.017023336,0.033663645,0.146068,-0.022120254 +2.7.1.60,Acts on the acetyl and glycolyl derivatives. ,384,1.0,-0.065832324,-0.093030855,-0.08189908,0.040027354,0.02490332,0.017238816,-0.023507258,-0.02098498,0.05907855,-0.0018629549,0.09893814,0.06442256,-0.10876936,-0.009748603,-0.039888486,0.040166717,-0.047564525,0.011582267,-0.058805946,0.032235987,0.015962178,-0.07367354,-0.033234034,-0.02075306,0.02876743,0.020746397,-0.0040559573,0.06981208,-0.0006695932,-0.13081203,0.009212396,0.014537191,-0.018894292,-0.024378855,-0.0020454947,0.03551657,-0.005793934,0.007677019,0.07961515,-0.00457295,0.04272072,-0.08325498,-0.075298935,-0.007865295,0.00670051,-0.09008879,0.01930274,0.01757346,0.013332824,0.050077498,-0.00788002,0.012110475,-0.044559643,-0.05811548,-0.03931232,0.039811384,-0.12869942,0.011558608,0.0979784,0.055212043,-0.028536318,-0.004311195,-0.057666145,0.07059596,-0.059763677,-0.05811689,0.092253916,-0.06500753,0.001792727,0.08875117,-0.041770592,-0.06305701,-0.078493595,-0.023206927,0.0599974,0.03400003,-0.0446033,-0.053238858,0.087582044,-0.017920146,0.021367256,-0.007399651,0.09312001,0.064476535,0.031857792,-0.0053908583,0.012218209,-0.05043063,0.0009450817,-0.005642652,0.035302065,-0.08977757,-0.01833416,-0.020156085,-0.012395496,-0.023207007,0.08571572,-0.048579972,-0.029910821,0.046313595,-0.02460515,0.011041159,-0.003087554,-0.03586982,-0.039743055,0.029056663,0.024615727,0.018971592,-0.0036119388,0.024886608,-0.09024066,-0.031124478,0.022696696,-0.067577526,-0.10935189,0.019629331,-0.025559194,-0.05848505,0.01656471,-0.063368574,0.041466113,-0.0015060172,0.009228669,0.078469306,-0.07029652,0.082535006,0.05815267,-1.315418e-33,0.06515056,0.05876147,0.008723909,-0.0024594867,0.038185686,-0.09141205,-0.061018564,-0.0070478525,-0.028080078,0.0016052291,0.03567227,0.015499958,-0.01853805,0.06382013,-0.042095285,0.05871751,-0.034575194,-0.052864604,0.033571977,-0.0029655797,-0.01466161,0.09443077,-0.046365537,0.031841878,0.007236056,-0.03602499,-0.014512931,0.088931985,0.012584056,0.018908272,0.052144364,-0.023071006,-0.084398314,0.032606915,0.029697858,0.113726586,-0.061809685,-0.0557993,0.10026959,0.010617001,0.018417131,0.03321163,-0.008699732,0.010350313,-0.041205797,0.045426052,-0.012496622,0.04359647,0.0128847305,-0.009053271,0.023053987,0.0074338717,0.03470379,0.049798142,-0.020491645,0.057529755,-0.047701094,-0.012663156,0.025034348,0.03840866,-0.010509551,0.026919385,0.04847378,-0.017313264,-0.020007873,0.07561331,-0.11086775,-0.038943272,0.002174463,-0.025130285,0.0007185705,0.032258667,0.15902261,0.029150246,0.026010979,0.02413715,-0.009006816,-0.0016062396,0.026937103,-0.003493608,-0.015215648,-0.03880568,0.023827491,0.011931585,-0.09644953,-0.044992168,-0.052279647,-0.09942597,0.005002062,0.0019979787,-0.0017302481,-0.01249007,0.013296314,0.02502789,-0.026885666,-2.4040672e-33,0.036675483,-0.07079348,0.03100994,0.017267816,-0.09973569,0.059918277,-0.027082903,-0.06289963,0.023704708,0.0574673,0.06923114,0.037336953,-0.0357458,-0.07229355,0.00030333412,-0.027795034,0.012498554,0.029162522,-0.057081606,-0.025544362,-0.02439907,0.08263356,0.026450256,0.07394199,0.069833286,-0.012654276,0.0012164713,-0.062127773,-0.012657047,0.0886095,0.027130721,-0.008668772,-0.04134725,-0.04570471,-0.009328281,0.07207404,-0.0069463113,0.03921913,-0.11885886,-0.00795098,-0.010482404,-0.020161692,0.087786965,0.056799788,0.1447974,0.062513925,-0.022924962,-0.01223997,-0.03886473,-0.060948737,-0.0022050275,0.07117869,-0.04911324,0.042158417,0.009063958,0.13922223,0.072617754,-0.062660396,-0.040882193,-0.057715997,-0.061167598,0.009222768,0.012261808,-0.07295361,0.08162654,0.014576937,-0.08613643,0.018466977,0.07694449,-0.03916858,0.014672593,-0.04855692,0.053745158,0.06519473,0.050532784,-0.04129201,0.0019939423,-0.14053099,-0.06643528,-0.04527305,-0.003765154,-0.011879648,0.008978086,-0.0037198556,-0.13263635,-0.049912248,-0.0080149295,0.045259412,-0.032075204,0.036847673,0.014498383,0.009900729,-0.048767846,0.01869244,0.02401217,-1.9893733e-08,0.050745063,0.012238037,0.061348554,-0.11108362,-0.05477535,0.0062203445,0.050990086,0.026768342,0.015604474,-0.016451878,-0.07776189,0.14190368,0.069651976,-0.03759902,-0.023343582,0.06340331,-0.06458748,0.049874313,-0.04743528,-0.03673551,-0.1030969,0.019095419,3.8514157e-05,0.034447894,-0.003274903,-0.09100205,0.050514273,0.057174545,-0.057316717,0.049266506,0.034475803,0.043789893,-0.023330662,0.014107737,-0.028748691,0.019666418,0.032984518,-0.04002049,-0.023422511,0.029181525,-0.05018376,-0.03298074,-0.015975129,0.042203102,0.01494976,0.032047287,0.0022794297,0.025768958,-0.00037359193,0.03314681,-0.013321325,0.026954455,-0.030408962,-0.031380355,-0.07900988,-0.026928047,-0.0752076,0.010532103,0.09885339,-0.0747845,-0.029676717,0.038677894,0.11073705,1.4127027e-06 +2.7.1.61,"Phosphorylates D-glucose and D-mannose on O-6, and D-fructose on O-1 or O-6.",384,1.0,-0.014146122,-0.032686662,-0.043281745,0.011142428,0.03953503,0.032584112,0.04635881,0.013799314,0.04414328,0.064152375,-0.06951554,0.053334873,-0.11918815,-0.02862739,0.0076686344,0.012297875,-0.038258128,0.04333985,-0.059913892,0.0077391514,0.11367494,-0.03305314,0.09790318,-0.005155118,0.08026787,-0.08500041,0.05944535,0.015025606,-0.03820449,-0.09449294,-0.0031871116,-0.02822901,0.009538031,0.043896396,0.04817718,0.0756927,0.1294886,-0.0049840887,-0.055496387,-0.025543133,0.005833832,0.0037614077,0.03607534,0.031600595,-0.079347216,-0.018991219,-0.121647164,0.10039852,0.0005928825,0.026288517,-0.011660753,-0.0544353,-0.034297056,0.064097226,0.060223397,0.11421385,-0.051509432,0.013210496,-0.02116134,-0.025312267,-0.06969624,0.0008444971,0.11356938,0.051387087,0.06745784,-0.05979335,-0.0030578102,-0.036806464,-0.072840355,-0.044271313,-0.051187806,-0.035800982,0.0075488677,-0.034954112,0.060835004,0.011734151,-0.045896683,-0.06262738,0.035108723,-0.009404101,0.06385466,0.015558247,0.061986532,0.043598033,-0.083315805,-0.061864123,0.024461603,-0.0014702296,0.032273065,-0.009737282,-0.027909355,-0.07546744,-0.025781676,-0.049089883,-0.06772559,-0.028508421,0.022428049,0.018738369,0.02786289,-0.029868813,-0.0007396545,0.039274633,0.010794668,-0.0027588375,-0.03342342,0.04421371,-0.031006584,0.06420916,-0.043556426,-0.029245054,0.07305623,-0.013432513,0.060550444,0.052961916,-0.13209301,-0.017510168,-0.04726494,-0.10345194,-0.0261663,-0.061310142,-0.0141668245,0.035968926,0.045172315,0.054797873,-0.055113684,0.060074173,-0.028900813,-1.4579065e-33,0.07107313,-0.061164342,0.042612515,-0.048651896,0.057225943,0.002039768,-0.030598449,-0.041800305,-0.019949274,0.01271852,-0.10572904,-0.03067855,0.042426474,0.011982132,0.034375243,0.0064768083,0.01668976,-0.0077800537,0.014475001,-0.0119474875,0.030581031,0.06108692,-0.016529573,0.02524885,0.040462,0.10620842,-0.06845202,0.066034056,0.009447368,-0.011097039,0.037487105,-0.026575668,-0.0034852466,0.048425943,0.038673233,0.011048303,-0.10312984,0.04975497,0.011345644,-0.027995514,0.04417159,-0.02103041,-0.03575945,-0.06651828,-0.039115477,-0.0051380135,0.029808795,0.022753924,0.04666107,0.09587757,0.01305478,-0.05810207,0.0028365706,0.05514902,-0.040304635,-0.006933454,-0.100737825,-0.02570081,0.04988469,0.0450329,-0.0405216,0.037339147,0.004882681,-0.0062183742,-0.014074745,-0.02950364,-0.051869888,-0.021538043,-0.035810433,0.056452118,-0.081004985,-0.017904663,0.039855823,-0.019870214,0.045216467,-0.008465545,0.010267504,-0.014268527,-0.07919462,-0.006625073,0.1197578,-0.032860547,-0.016509674,-0.0025300996,-0.08284822,0.0090858275,-0.085968874,-0.08461151,-0.024925122,0.053906042,-0.030671258,-0.024191244,-0.044802,-0.0069596837,0.008882548,-1.9319556e-33,0.05333086,-0.05510393,0.1075758,-0.028709998,-0.032468483,0.056234278,0.07540444,-0.059841,0.012480477,-0.08331504,0.007873079,0.034425274,-0.07710156,-0.057264455,-0.00964002,-0.010093361,-0.054943204,0.07647048,0.033560816,0.052929215,-0.07187378,0.052662008,-0.10016625,0.011357698,0.099217534,0.0067302994,0.03689566,-0.01887375,0.03346477,-0.0021310167,0.07158908,0.018561581,0.035292044,-0.021409735,-0.015434449,-0.046637937,-0.034890026,-0.010550313,-0.07210976,0.06003661,-0.055907026,0.027850041,0.05896391,-0.077476636,0.07566739,0.041475814,-0.115255,0.02297363,-0.081589974,0.036636528,0.0115234535,-0.04861028,-0.018608248,-0.004724468,0.03495924,0.05045412,0.033019166,0.017629774,-0.0068671014,-0.03924495,-0.0072977273,-0.06925727,0.061732437,0.017942132,0.00889531,0.020674666,0.0056965705,0.025518596,-0.00894239,0.07103782,-0.0108065475,0.026586056,0.012791228,-0.016026381,0.018768506,-0.051828634,-0.11257739,0.0085737305,0.050949994,0.04430513,-0.07949396,0.03806879,-0.037726253,-0.022358015,0.016051112,-0.031670894,0.04893263,0.03684168,-0.02333283,0.08063833,-0.095894784,-0.039426588,-0.021904385,-0.028727885,0.05311753,-2.436146e-08,0.10345133,-0.07139743,-0.009556608,-0.0063049737,0.025847498,-0.009947266,0.06447541,0.08617414,-0.048494283,-0.00904112,0.025603978,0.14111388,0.050305825,-0.07932559,0.04251281,-0.044884972,-0.03940534,0.009110264,-0.046378754,0.05029375,-0.043932915,0.0073572253,-0.10287602,0.050584972,0.042751368,-0.01503697,0.07734524,0.011214363,-0.005538334,0.0028263319,0.085495345,0.03388528,0.048018944,-0.10206482,-0.009565508,-0.030275965,-0.048428033,-0.043274328,-0.031544898,0.034980398,0.018629087,-0.0065451823,0.04953441,-0.005640787,-0.030518472,0.010180071,0.006480213,-0.013811373,-0.05634418,0.064015955,-0.032828495,0.03580916,-0.12984785,-0.033138894,-0.08317276,-0.037571598,-0.0053577214,-0.06514913,-0.043249343,-0.04486212,0.07655058,0.002388609,0.13838364,-0.07009488 +2.7.1.62,Activity is observed with several hexoses; of these glucose is the best substrate and the product from it is alpha-D-glucose 1-phosphate. The phosphoramidate donor can be replaced by N-phosphoglycine and by an N-phosphohistidine. May be identical with EC 3.1.3.9 glucose-6-phosphatase.,384,0.99999994,0.005828889,0.0056205173,-0.0823576,-0.06290223,0.03748713,0.04379436,0.06770106,0.048909057,-0.007923885,0.05298696,-0.009642136,0.04494873,-0.08831848,0.05226503,-0.023183318,-0.03724328,-0.028563168,-0.009562258,0.00021754658,0.004117148,0.117349595,-0.05315293,0.047169756,-0.021266717,0.066495314,-0.017095588,0.061393235,-0.041498132,-0.016428353,-0.08047403,-0.056090016,-0.026573874,0.061992332,-0.0785458,-0.017367505,0.13976309,0.008593912,-0.053509012,-0.06935334,0.0050912234,0.05861247,-0.036820088,0.03128431,-0.018932858,-0.070068456,-0.0090808235,-0.039515182,0.05028904,0.09611577,-0.03248272,-0.06060341,-0.08887443,0.0075866426,0.0059950864,0.009422024,0.0999945,-0.1342383,0.03037154,0.017954227,-0.07670902,-0.035041012,0.025405353,0.060199294,0.052065544,0.059198137,-0.017356813,-0.0051088817,-0.13846841,-0.06694583,0.0078491485,-0.047107738,-0.029606957,0.0406106,-0.026751244,0.017781988,0.11103901,-0.009027153,-0.016339872,-0.0005569387,0.0025687094,0.0126420455,-0.023127714,0.00040978534,0.071886316,0.013394045,0.054233246,-0.016455417,0.0043817684,-0.0056342287,0.014545794,-0.028618352,-0.00496735,0.04406332,-0.034731884,-0.04961284,0.02904324,-0.0105315205,0.046692118,0.07428262,-0.012732854,0.025888473,0.13208903,0.008502599,0.00024596206,-0.07740915,0.060515523,-0.049944945,0.01511662,0.0030775687,0.029264089,-0.016214598,0.015018031,-0.0012743457,-0.0078168195,-0.071305,0.10526994,-0.049796987,-0.09547148,-0.05240739,0.006642194,0.007679782,-0.04969255,0.075817764,0.017450683,-0.016077006,0.10904014,-0.0377813,6.8855426e-34,-0.0029786003,0.02137829,0.008218756,-0.061912403,-0.009477631,0.021594506,-0.05082303,-0.04565112,-0.0032199107,-0.10416955,-0.099240296,0.016011078,0.030498246,0.026025817,-0.04875063,-0.02979575,0.028841784,0.060198206,0.06947037,0.03550303,0.045517784,0.01967167,-0.008354802,0.037980992,0.09233749,-0.0017025974,-0.06273638,0.012338815,0.012335567,-0.0045997743,0.042990472,-0.021752069,-0.032496274,-0.04031182,-0.08883794,-0.0498608,-0.08183808,-0.05031821,0.03580513,0.026176212,0.03900209,0.010350924,0.062160373,0.008710783,0.050411765,-0.036848757,-0.015487833,0.0073947096,0.06896101,0.01916062,-0.038117077,-0.031980585,0.059120446,-0.06141049,-1.2724641e-05,-0.03154021,-0.035801277,-0.035608105,0.044469133,0.05963991,0.021252701,0.12647636,-0.0013609447,0.03447671,-0.011344865,0.012287171,-0.032264534,-0.058644094,-0.14107956,0.013275778,-0.024353672,-0.071804754,0.024390588,0.015379999,-0.0039907345,-0.07649518,-0.0003813717,-0.0057006613,-0.026642388,-0.0142410975,0.10585995,-0.02326291,-0.044796254,0.0015787684,-0.07988079,0.037104774,-0.04767607,-0.085974775,-0.01112672,0.04486173,0.018837908,-0.06886461,-0.087869585,-0.031125858,-0.03671346,-2.8409867e-33,0.086415336,-0.08405154,0.10364164,-0.040169235,-0.009496117,0.07406039,0.071463026,-0.024001895,0.097930625,-0.027204279,0.028802026,0.044537593,0.023162335,-0.12040017,-0.05795478,0.044325966,-0.022417422,0.036691606,0.015920594,-0.05206181,-0.0067378655,0.14704286,-0.023833426,0.026621053,0.079057015,-0.02695128,0.015205739,0.08794893,0.023754055,-0.027044542,-0.029775675,-0.023281371,-0.030995896,-0.019362979,0.014508032,0.064329386,-0.046659898,-0.028455246,0.0062079905,0.011302451,0.029760214,0.03577998,0.09040426,-0.0375254,0.042774536,0.09116482,-0.07468472,0.03921778,0.013587406,0.022830924,-0.04059864,0.039202202,-0.07410537,0.054385487,0.050349142,0.107966594,0.0052853194,0.04792514,-0.046598077,-0.060683213,-0.0011119578,-0.05952696,0.047237113,0.016452758,0.024057565,0.039729755,-0.012808377,0.0087078195,0.0029915127,0.081098564,0.022395683,-0.018250043,0.008241812,0.03146475,-0.006652568,-0.0041216686,-0.10606993,0.0071598478,0.017529277,-0.05209375,-0.0030716355,0.014721945,0.0014536214,-0.040644445,0.0943369,-0.0085938675,0.06281185,0.019454567,-0.031700008,0.04578871,-0.018074224,-0.048364192,-0.072286956,-0.0088220285,0.08403561,-4.2042235e-08,0.10812067,-0.05616117,0.027237214,-0.04309582,0.019241242,-0.059428286,-0.008546532,0.008847421,0.04583402,-0.057443254,-0.04539466,0.078977585,0.047654003,-0.024872027,0.055619795,-0.010839612,-0.081642516,0.02861855,-0.046016596,0.0012266322,-0.094086416,-0.014947672,-0.07183786,0.013103282,-0.008028542,-0.0011530027,0.10956749,0.01972706,-0.056415137,-0.013425278,-0.004179308,0.011086393,-0.0035865721,-0.022984168,-0.019388283,-0.011539134,-0.06495726,0.038683984,-0.040292673,0.023419393,-0.0073966803,-0.07714318,-0.025192754,0.051374916,-0.037256632,0.047377825,0.0070537226,-0.0090512745,-0.04966194,-0.0024546818,-0.009256185,-0.019876786,-0.07347761,-0.10953906,-0.060951613,-0.04671852,-0.030285483,-0.025834842,0.038455628,-0.011165108,0.04689074,0.040014558,0.16457239,-0.039822582 +2.7.1.63,"Requires a neutral salt, e.g. KCl, for maximum activity. Also acts on glucosamine.",384,0.99999994,-0.010242533,-0.09618558,-0.0016696338,-0.007262233,-0.029930592,-0.030142317,0.02416217,0.062285047,0.030676477,0.0102946265,0.023247357,0.033856127,0.006585054,0.1237494,-0.037862852,0.008621119,0.060975254,-0.03327673,-0.06108357,-0.0073819445,0.14038816,0.009163189,-0.0007354078,-0.027946021,-0.044171933,0.057458118,0.032273684,-0.014604881,0.028897865,-0.0024550764,-0.07088561,0.03246819,0.036956865,-0.028706225,-0.012560125,0.1061516,-0.13462411,-0.040672418,-0.00808721,0.052650437,0.017821673,-0.03302405,0.017088503,-0.031138647,0.010873237,-0.010925445,0.05369229,-0.042142157,0.041386034,0.06319325,0.050926473,0.023472492,0.041804157,0.017105566,-0.006039243,0.012718373,-0.16223769,0.023049463,-0.05742115,0.049118977,-0.045194503,0.03809397,-0.044984747,-0.022645017,0.04777838,-0.03991654,0.03015213,-0.01699972,-0.013848789,0.0071887393,-0.01694357,-0.03415665,0.08149228,-0.003268427,0.0126719,-0.06389959,-0.011932357,-0.05302818,0.047718063,0.0005438255,-0.05475632,0.031117916,0.03175393,0.10187835,0.06616005,0.04947911,-0.019727882,-0.0045374236,-0.0427887,0.024405956,-0.0091547,-0.011392067,-0.068499275,-0.022008477,0.017519083,-0.0037059085,-0.05470644,-0.011555269,-0.09364721,-0.012863926,-0.028814351,0.021720016,0.02309951,0.009824686,0.012386687,-0.050050914,0.042316884,0.026896093,-0.009670949,0.066469386,0.013938577,0.0647981,0.0120847635,0.03492411,-0.05714652,0.107753925,0.038224816,-0.042478986,-0.086784914,-0.030733552,0.0289008,-0.06541845,-0.035218604,0.06752744,-0.08957449,0.010824726,0.07017806,-2.261113e-33,0.03974475,-0.0020290758,0.061455764,-0.054841854,-0.07151434,0.02185696,-0.084773436,-0.017289128,0.053606648,-0.027862858,-0.034877274,0.018516626,0.054462783,0.041538548,-0.031268425,0.021959387,-0.0403523,-0.042702604,0.12350889,-0.050158527,0.08912458,0.030852025,-0.013110282,0.022910258,-0.09226157,0.04153412,0.026985062,-0.021163572,-0.004689734,-0.03431237,0.024502944,-0.034601238,-0.011637713,0.040109,-0.028518686,0.12683144,-0.079262085,-0.007686685,1.5665952e-05,0.020195775,0.017950226,0.0335399,-0.0020790847,-0.004038751,0.063798204,-0.05343897,-0.051986266,0.028475272,-0.034439493,0.08929871,0.09144239,0.012480234,0.041635614,0.01047633,-0.08074077,0.050816532,0.013462478,-0.09422857,-0.01885085,0.10930418,-0.034550145,-0.021006338,-0.048251737,0.052133534,0.0008974724,0.05073518,-0.091296986,-0.046108548,-0.03447386,-0.01730345,-0.030079955,-0.027568223,0.07425874,0.046930943,-0.061218396,-0.01347789,-0.046006687,0.08209521,0.03795113,-0.009089437,0.048786595,-0.11096763,0.015594658,0.07343421,-0.092898,-0.0108633675,0.0065900465,-0.030146109,0.037111115,-0.0041821566,-0.014087914,-0.068642996,-0.058690786,-0.005217131,0.039955795,-5.9428237e-34,0.08904782,-0.045999937,-0.003908648,0.043082446,0.08300916,0.030095203,0.051211707,-0.1149975,-0.023168078,-0.017339753,0.025538655,-0.01533322,-0.06760768,0.055569954,-0.029030684,0.038754057,-0.09181632,0.11650948,-0.054473486,0.03886646,-0.022571344,0.13539071,0.018289123,0.07045998,0.086812824,-0.003324131,0.0071722087,-0.014539452,-0.049447723,0.04051223,0.017859252,-0.036381885,-0.071704395,-0.11564009,-0.014645981,0.01817083,-0.034942787,-0.03484991,-0.06462286,-0.024828894,0.027156882,0.030373236,0.07348416,0.06757955,0.021218937,0.032417916,-0.02226324,-0.080486216,-0.08188563,-0.027401643,0.043242663,-0.02751355,-0.010653577,-0.04273867,0.07150389,0.020733185,0.005534222,-0.040395617,0.0036472674,-0.037492495,-0.025506804,0.039156016,-0.054182053,-0.08392134,0.028331023,-0.07692373,-0.008194475,0.07172305,0.051836416,0.025832012,0.027679017,0.01831632,0.16047353,-0.026458642,-0.042802703,-0.0362346,-0.03032669,-0.019693853,0.040549453,-0.09697704,-0.028027674,-0.0216893,-0.019342981,0.006338793,-0.013528087,-0.013605818,0.031747412,0.0026042012,0.006460432,0.02861521,-0.026819943,-0.07610167,-0.049616203,0.0977838,0.07156586,-2.7281102e-08,0.020812096,0.053025454,-0.036053825,-0.019207876,-0.053246133,0.077834174,0.08537778,0.0005475569,0.015935637,-0.03536037,0.038105443,0.061804872,0.03740728,0.0038431264,0.0015036679,-0.027374867,-0.018426914,0.04669365,-0.040981248,-0.054983437,-0.16663814,-0.08694354,-0.060627166,0.067865856,0.046165626,-0.07058914,0.00469538,0.083807945,0.0013995783,0.013186733,0.017051265,0.013240028,-0.04582167,-0.055840172,-0.013658819,0.07597878,0.03619453,0.029698126,0.0024067934,-0.005221799,-0.13851745,0.050170127,-0.017563906,0.034480505,0.018377881,-0.026482772,-0.02444719,0.01655187,0.021894986,0.023256466,0.045859355,-0.025621532,-0.021144215,-0.066013254,-0.07709729,0.018866818,-0.05472295,-0.07658885,-0.0030157308,-0.06827585,-0.0042159786,0.03109788,0.056542248,-0.0034454402 +2.7.1.65,"Also acts on streptamine, 2-deoxystreptamine and 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol.",384,1.0,-0.06247304,-0.12377292,-0.106917955,0.024244422,0.014743133,0.004300958,0.06739542,0.031733986,0.04811681,0.0504315,0.016619463,-0.021205815,-0.06383036,0.083617754,-0.008103197,0.1000215,-0.01234549,0.027181003,0.053216834,-0.021427447,0.08343942,-0.02607505,-0.031408668,0.065712996,0.008369914,0.06292308,0.0019587302,0.016606456,-0.05893066,-0.062748246,-0.06056808,-0.022860557,0.027586583,0.032835755,0.04338156,0.11026475,-0.120522544,-0.010058481,0.0145235555,-0.0017167671,0.044052124,-0.012187666,0.04084268,-0.003637844,-0.021760877,-0.049819317,-0.034834463,0.036558673,0.051472537,-0.008888402,0.01165111,-0.083076335,0.00036228803,0.08853968,-0.013656739,0.054540824,-0.10634335,0.08638882,0.0016499802,-0.00084973377,-0.03311387,0.030519452,0.035395347,-0.007965916,0.055347737,0.0076429653,0.022394821,-0.0236259,-0.0134832775,-0.0039812396,0.04971986,-0.047938682,0.059032347,-0.025666822,-0.032760218,0.003924854,-0.028300976,-0.0038021293,0.017790014,-0.050780572,-0.007844561,0.021381382,0.046765607,0.038632676,0.0583686,0.050227053,-0.058842927,-0.008816569,0.023237633,0.05246034,0.025181936,-0.03084536,-0.039359167,-0.019259108,-0.021003468,-0.027675895,0.03643231,0.0037334736,0.020327277,0.03322961,0.028271407,0.044553377,-0.051750034,-0.07433038,-0.006833161,0.020786151,0.057945564,-0.066822425,-0.037998382,0.0014418109,-0.050177235,-0.05926144,0.052777775,0.08054642,-0.014476766,0.06401665,0.04556053,0.023833685,0.027951393,-0.023313917,0.01561813,-0.044403773,0.0071817264,0.035082262,-0.1017007,0.052913275,-0.010036351,2.8021607e-33,0.045343563,-0.039680433,-0.0016509191,0.072396815,0.008988636,0.06274478,-0.0066323467,-0.013028549,-0.010543053,-0.019878138,-0.15886465,-0.052419573,0.10790645,0.095856905,-0.028801076,-0.028169269,-0.073526606,-0.021251276,0.12426022,-0.06774767,-0.006566228,0.102966614,-0.074665874,-0.006802984,-0.045793563,0.022144297,-0.100186676,0.031961717,0.027196681,-0.008023785,0.029545315,0.00013285618,-0.11277571,0.042210855,-0.030066373,0.093555,-0.071815155,-0.014844831,-0.011672939,0.0629794,-0.008353702,0.013244986,-0.10538002,-0.032907847,-0.0078753,-0.051169198,-0.054764345,0.041030366,0.043410573,0.021306291,0.050937448,-0.07280339,0.05063102,-0.06386871,-0.060504947,-0.0020758966,-0.0016519798,-0.06420657,0.05231931,0.05811161,0.016123783,-0.0074070347,0.010524764,-0.06007079,0.037627112,0.026206203,-0.09454463,-0.036211275,-0.031866796,-0.021223864,-0.07271113,-0.043335795,0.035385985,-0.0003507281,-0.002891809,0.0120125385,-0.04118363,-0.012109801,-0.027700907,0.05875882,0.017000904,-0.12271707,0.04502216,0.033206243,-0.046471298,0.050166365,0.04739923,-0.1476055,-0.04890713,0.06624718,0.029784814,-0.08588492,-0.075312205,-0.0069724605,0.06907011,-3.8809328e-33,-0.018522643,-0.058360063,0.058508232,-0.057656165,-0.06460343,0.09393693,-0.01669106,-0.09130412,0.045332182,0.013511083,0.10363475,-0.06494602,-0.04312733,-0.024046052,0.015849764,0.0021377897,-0.063088834,0.03160907,0.020089038,-0.005314939,-0.0033503931,0.08501516,-0.03356344,0.061017215,0.008581264,0.017813329,0.024850914,-0.034950927,0.046252836,0.09556552,-0.015246492,-0.031011129,-0.07511531,0.017130462,0.0021666447,0.02285666,-0.034497,-0.015711114,-0.00027657615,-0.07577886,0.025188401,0.033545833,0.09814701,0.12970391,0.0531355,0.09327392,-0.079581544,0.006039191,-0.12006424,-0.013152741,-0.0203933,0.012204732,-0.04679361,0.0048856414,0.078463525,0.0125296535,-0.02292671,-0.09387912,-0.04754862,-0.04042403,-0.034300566,-0.005248535,-0.043785032,-0.033805016,0.07986849,0.007178814,-0.04078814,0.055425875,0.08649035,-0.017347995,0.058088746,-0.051393434,0.0050955736,0.018944062,-0.0838102,-0.09284101,-0.06251211,-0.0068701943,0.08223104,-0.1023201,0.0064727715,-0.027137304,0.022442797,-0.029341752,-0.011382583,-0.019656355,0.042003304,0.11872008,0.043652978,0.058057245,0.012372618,0.0462504,-0.0141734155,0.039641418,0.05753107,-3.7797324e-08,0.049240973,-0.0337472,0.058547154,-0.0182106,-0.03767831,0.011158924,0.07402819,0.09280211,0.005398249,-0.03757826,-0.003974788,0.05772746,0.08716956,-0.05859317,0.05938569,0.07588815,-0.034417737,0.06309619,0.008607659,-0.042971663,-0.073511474,-0.058663126,-0.044666402,-0.00044461968,0.013118367,-0.070689015,0.03436231,0.111608446,0.035734218,-0.010856066,0.013649159,-0.037559774,0.010875561,-0.09038825,0.017800976,0.04930583,-0.026808666,-0.059354868,-0.0017042359,-0.034600925,-0.049000226,-0.018488696,0.009717984,0.0089144055,0.0110229915,-0.017688723,0.031692937,0.015153489,-0.00553963,-0.02971592,-0.016710963,-1.549729e-05,0.018029083,0.005020902,-0.09811746,-0.0075520887,-0.016988195,0.0032603564,0.017160928,-0.021673111,-0.03155879,0.057213884,0.04091382,0.011759483 +2.7.1.67,This reaction is catalysed by at least two different isoforms.,384,1.0,-0.030442704,-0.028143052,-0.074291386,0.026267946,0.048834782,0.02181363,-0.05411521,-0.02493901,0.035142902,-0.05441748,0.07329449,-0.07307698,-0.07112735,0.013055112,-0.006855828,0.04024386,-0.08199697,0.032495316,0.016375922,0.0043425653,0.08056668,-0.07519726,-0.017298266,-0.027609902,0.04456405,0.07786059,0.039541267,-0.0051912754,0.021848133,-0.08987014,0.019227097,-0.04856691,0.02014388,-0.077471875,0.006651648,-0.047724985,-0.08208811,-0.014509907,-0.006672388,-0.025432546,0.019305402,-0.06942662,0.016610565,-0.047788538,-0.016023168,-0.018496798,-0.013082454,0.02719701,0.01457158,-0.045148365,0.028223436,-0.038033184,-0.10075729,0.023842074,0.035469476,-0.042310476,-0.069244176,0.04133553,0.032461066,-0.005362113,0.0026099575,-0.0034250522,-0.05746435,0.017156072,0.06262142,-0.042954717,-0.01199155,-0.084092945,0.028639698,-0.034948662,-0.02243823,-0.048486404,-0.03074799,-0.058319908,0.0007633239,0.0074194805,-0.0075824894,-0.024614437,0.045864414,0.05187964,-0.02779097,0.05323113,0.017710125,0.010105279,0.016331924,0.044377077,-0.03998231,-0.008135079,0.039047368,0.010716307,-0.0213997,0.074629776,0.03871795,-0.027126433,-0.0056659235,0.06763707,0.060297415,0.13021359,0.09185916,-0.025393223,0.01882835,0.032574836,-0.16139261,-0.1355682,-0.023622757,0.05872841,0.016520226,0.028030615,0.035375863,0.017538702,-0.03595068,-0.026631037,0.046843152,0.032463465,-0.018193698,0.09631906,0.03863415,-0.042506326,-0.103155434,-0.0042636083,0.0788317,-0.04446284,0.0003946916,0.035746954,-0.09416937,-0.0371025,-0.077747524,-1.4109069e-33,0.04817406,0.09986131,-0.01780388,0.032055676,0.028456839,0.026074959,-0.07847218,-0.014074373,-0.06330641,-0.010250869,-0.107822455,-0.062386796,-0.0017057937,-0.0037451144,-0.07885123,-0.028853938,0.017758794,0.07377063,0.039028972,-0.032729257,0.0020097753,0.11865581,-0.048411842,-0.015983853,0.021583559,0.022920301,-0.018848918,-0.026308836,-0.015845034,-0.042373955,0.04884721,-0.0446188,-0.117574565,0.01215198,-0.01425276,-0.025728004,-0.05396387,-0.015930586,0.008620269,0.058194257,0.066876486,0.021766443,-0.04643222,-0.032149788,0.07512365,-0.016032858,0.0048238495,0.055646155,0.09063205,0.02708641,0.020025047,0.037706435,0.037481952,-0.014857705,0.0006427408,0.052553583,0.019476952,-0.029339697,0.03437734,0.029306874,0.00256223,0.0891106,0.004172092,0.0012829738,-0.007218799,0.030708682,-0.07146517,0.0042789797,0.018396018,0.06865811,-0.0387433,-0.012236277,0.08716308,0.0032026,0.06760307,-0.05825918,-0.022545746,-0.0154063795,0.06684427,0.02339073,-0.090167895,0.050458822,-0.00032895472,-0.02222462,-0.043946438,0.0197254,-0.08836525,-0.038102895,-0.03400531,0.09988202,0.010229207,-0.059852567,-0.12892541,-0.009525022,0.044470675,-1.1953981e-33,0.035668615,-0.08573141,-0.054015018,-0.11642713,-0.08567975,0.030686753,0.025681356,-0.072160855,0.023730582,0.070443824,0.018912045,-0.026185665,0.011149744,-0.008056098,-0.011953298,0.022295712,0.017950926,0.121058576,-0.0010467125,-0.0015694004,0.0075405263,0.06961215,-0.04319633,0.1001283,0.028881153,0.03582021,0.047971424,0.036452945,0.10655698,0.082978204,0.009126859,-0.07052909,-0.027354715,0.012257461,0.016591718,0.08686063,-0.014440826,0.020748971,-0.029391088,-0.037180442,-0.040683452,-0.020551281,0.029327754,0.09051796,0.032212157,0.006776869,0.026729144,-0.0057285796,-0.05245227,-0.05682813,0.050125163,-0.015451972,-0.122175716,-0.0050318935,0.0014918891,0.08374099,-0.04544038,-0.015334667,0.010054501,-0.06510991,-0.02121175,-0.03711826,0.07957328,-0.087993465,0.04138476,0.051868163,-0.015996557,0.067459844,-0.027804771,-0.011385688,0.14993222,0.004521127,-0.006395777,-0.033488296,0.039005183,-0.094507985,0.007781009,-0.023811607,-0.038530182,-0.034997683,-0.043671362,-0.033067748,0.029053725,-0.052067827,-0.062216796,-0.0044561457,0.042005938,0.08303383,0.009495097,0.061753392,0.0027262694,0.06905612,0.05804361,0.08334438,0.10449437,-2.249212e-08,-0.0014109336,-0.0688311,0.06339547,-0.047940847,-0.08756046,0.09117571,-0.038117416,-0.036132928,-0.017130004,-0.0873074,-0.018745916,0.06469313,0.06843429,0.015506253,0.03447885,0.017011268,-0.08322865,0.007490318,-0.02336383,-0.03241006,-0.06650581,0.024061328,-0.051426508,-0.02349663,-0.03967418,-0.04151118,-0.0018484521,0.046892133,-0.02207571,-0.027939836,0.046745654,0.02251345,-0.06800705,-0.024209395,0.006980285,0.009625981,0.011281877,-0.05786864,0.03517367,0.0019080496,-0.031538352,-0.066431455,-0.03847265,0.07089667,0.013207528,0.042081583,-0.042728405,-0.0647969,0.005530415,0.048188582,0.07382452,-0.031361703,-0.003431252,-0.03485865,-0.032864973,-0.004199751,-0.006501068,0.009035357,0.05257134,-0.007541958,0.0888039,-0.0055530868,0.18371937,0.011759854 +2.7.1.68,"This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known.",384,1.0,-0.023731437,-0.099420816,-0.07052412,-0.07086968,0.005304179,0.047859155,0.023853645,0.022051107,0.09829851,0.053200487,0.02697278,0.044421617,-0.062227417,0.0945871,-0.024268463,-0.009433872,-0.094450004,0.037254803,0.051999476,-0.073792845,0.017219404,-0.019483238,-0.0005833997,0.021518687,-0.027462069,0.019364249,0.07463328,-0.045636173,-0.004592303,-0.042273544,-0.08322697,-0.06770389,0.010357194,-0.059230745,0.010395894,0.09235163,-0.07964568,-0.045585256,-0.013530205,0.035597358,0.108253025,-0.030254874,-0.045480736,-0.051717553,0.017657854,0.037668113,0.00641806,0.0064749704,0.091090895,-0.018902896,-0.027618952,0.0038471962,0.0146326395,0.022540392,-0.0033676622,0.035534713,-0.061682425,0.045023266,0.010738318,0.033155978,0.0028721339,0.01851076,0.0020939498,0.047619205,0.120825395,0.020743046,0.04481705,-0.026403526,-0.0016548816,0.0050038933,-0.055622093,0.007318279,0.023102058,-0.049345594,0.007452508,0.04274308,0.013261002,-0.015932508,-0.035579313,-0.04791718,0.04095701,0.004026528,0.019401183,0.07582719,-0.037200864,0.011256967,-0.06838557,-0.026584713,0.025682194,0.017180707,-0.02447363,-0.007977697,-0.056247324,-0.006647921,-0.028105421,0.057461865,-0.0008064536,0.0152041055,0.038987864,-0.08622142,0.011981593,0.08640671,-0.06834373,-0.0456947,0.027385548,0.061180964,-0.07242325,-0.002230799,0.011894832,0.025611633,0.0006382944,0.00012319996,0.044791058,-0.03560402,0.022938339,0.06146665,-0.08247598,-0.094156325,0.025367575,0.016823664,0.013720181,-0.03084318,-0.04438253,0.058872767,-0.09763718,0.0067421864,-0.01731008,1.3174014e-33,0.0032838092,0.090856805,0.017716786,0.03684664,0.048670188,0.023131892,-0.024190355,-0.046700817,-0.09482866,-0.07652493,-0.046600245,-0.15040267,0.06052259,0.0070240377,-0.08021778,-0.008691676,-0.008382831,0.101723194,0.051743753,0.040548295,0.06593079,0.08353003,-0.07882414,0.013153816,0.039523054,0.1048331,-0.044652242,0.03990113,0.028500741,-0.017292349,-0.019938478,-0.0377023,-0.1032758,-0.01068752,-0.010038803,-0.073465176,-0.00021467288,-0.039337076,0.024829753,0.05272386,0.021193372,-0.028721457,-0.055670872,0.02329033,0.042830396,-0.08543274,-0.0407006,0.033258542,-0.029418368,0.0625177,0.054772995,-0.0039328025,0.108652934,-0.031276535,-0.044852052,-0.025688505,-0.078822024,-0.0253899,0.10378897,0.037421826,0.028767934,0.055896115,-0.046435162,0.014635169,0.032083593,0.068754934,-0.05769598,-0.07442811,0.043358795,0.10544014,-0.05412047,-0.0072971336,0.010029618,0.03992732,0.08325159,0.0015223089,-0.03318854,0.022044793,-0.019365344,0.019999554,-0.08478887,-0.057504214,0.044360008,0.11934537,0.015857138,-0.07221414,0.040556952,-0.08470627,-0.0053679626,-0.019506546,0.096801996,-0.04831396,-0.044816546,0.027588805,-0.028813906,-3.5486496e-33,0.09751488,0.014356227,0.004204726,-0.08832351,-0.13529925,0.028849022,-0.008561879,-0.037488475,0.040681835,0.0148808835,0.06817202,-0.020583808,-0.01951148,-0.07601561,-0.063103646,0.062281255,-0.016668396,0.071739934,-0.020608915,0.00082904164,0.041820634,-0.014411246,0.009616624,0.1310912,0.05891809,-0.03024322,0.021632122,-0.0024687855,0.004093821,0.081993334,0.00059067976,-0.008098169,-0.05037097,0.042898025,-0.0133831315,0.00020970212,-0.048947945,0.027246974,0.04650595,0.05764253,0.08034242,0.047686737,0.07551197,0.004877009,-0.043492906,0.040461857,-0.033615835,0.07057416,-0.052211825,-0.06516989,-0.027725657,0.026658036,-0.021370595,0.01302168,0.03217824,0.0461039,0.040703606,0.013629754,0.03872813,-0.05953028,-0.05825137,-0.074479096,0.09746529,0.047834057,0.07045109,0.054946862,-0.03970043,0.015983298,-0.029024495,-0.020039473,0.047144443,0.046584066,0.033225797,0.07261397,-0.016390132,0.0075131827,-0.011265289,-0.029564312,0.02927836,-0.037127096,-0.004011785,0.0014766456,0.024357205,-0.115160815,-0.024497245,-0.020451805,0.033071354,0.10319533,0.011044335,-0.02026979,0.00081372506,-0.01245146,-0.05202854,-0.035091463,0.115673944,-3.9681904e-08,0.043602157,-0.006260486,0.03551795,-0.06695359,-0.11066513,0.023841772,0.012695731,0.05368178,0.0034227755,-0.01916068,-0.046050217,-0.018364048,0.04754134,-0.048256267,0.080959424,0.07330371,-0.025406064,-0.020604834,-0.031137332,-0.05766179,-0.06381798,0.009738512,-0.08731982,0.013315338,0.054281082,-0.018674519,0.010847744,0.0094778985,-0.012509549,-0.05244199,0.0063870656,-0.02146729,-0.057582233,-0.064923495,0.023239654,0.047836035,-0.08091879,-0.0030675754,-0.08480339,0.044068452,-0.10277262,-0.08425222,-0.045525543,-0.0017649096,-0.019756295,0.027426267,-0.0051790336,0.0013402371,-0.02549416,-0.056598533,0.018281596,0.0029481216,-0.02128248,-0.09380258,-0.07610748,0.028673856,-0.05222071,-0.07667918,-0.049346246,-0.06392963,-0.014139131,0.073453605,0.121953025,-0.023791615 +2.7.1.69,"Enzyme II of the phosphotransferase system. Comprises a group of related enzymes. The protein substrate is a phosphocarrier protein of low molecular mass (9.5 kDa). The protein is phosphorylated in a reaction catalysed by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase) and this acts as the phosphate donor for the above reaction. The enzyme translocates the sugar it phosphorylates into bacteria. Aldohexoses, and their glycosides and alditols, are phosphorylated on O-6, whereas fructose and sorbose are phosphorylated on O-1. Glycerone and disaccharides are also substrates.",384,1.0,-0.012992786,-0.038616627,-0.06428995,-0.0010465854,0.043681335,0.042388596,-0.0026494563,0.028293058,0.03644606,0.014772916,0.021815337,0.0036489058,-0.030291704,0.018140443,-0.03511423,0.020186625,-0.023649955,0.028994422,-0.0082289325,-0.03697491,0.19482912,-0.010579846,-0.02939582,-0.015790658,0.06210605,-0.03793166,0.0121444,-0.050234172,-0.05195086,-0.06936813,-0.034115113,-0.09742589,0.023041777,-0.03220626,0.020349698,0.13761853,0.026701823,-0.0981235,0.029758038,-0.018341208,0.036738753,-0.00552995,0.012908865,-0.0055172727,-0.02580679,0.032036956,0.005838566,0.080365,0.0065665185,-0.010281471,-0.06129317,-0.063334785,-0.06236555,0.061341453,0.02541127,0.09736008,-0.060274996,0.04246646,0.0040339404,0.0052424986,-0.04120461,0.028970076,0.046430238,0.06940663,0.0185702,-0.04427322,0.02939623,-0.08252634,-0.048263617,-0.05943883,-0.061106306,-0.0340107,0.057338964,0.029898625,0.08813961,-0.006008103,-0.05610542,0.04854103,-0.03552438,-0.0045325705,0.06635723,-0.025191061,0.004769358,0.011999978,-0.060905874,-0.05462859,0.014934352,0.029537756,-0.0023897807,0.0078315595,0.007803239,-0.058919378,0.06491604,-0.0104414355,-0.024780301,-0.034640796,0.020191327,0.006924882,0.04735542,-0.04306702,-0.0011856437,0.04934408,0.04673166,-0.05656339,-0.013067738,0.06756474,-0.056823894,0.09043773,-0.0017541825,0.026863359,0.05113335,0.06651298,0.074627854,-0.028007347,-0.008869302,0.049010377,-0.008658979,-0.08197878,-0.10224863,-0.015458952,0.009665564,-0.043266803,0.06593549,0.06355711,-0.09623587,0.074233286,-0.12004366,4.394517e-33,0.036891524,-0.008546311,0.030931149,-0.062634066,0.026983377,-0.05232794,-0.017860517,-0.002326966,-0.017187562,-0.04795812,-0.06381512,-0.05111403,0.054410644,0.060142256,0.023213586,-0.023507249,0.023163795,0.030736744,0.109363414,0.035545535,-0.00930503,0.03471983,0.0017991806,0.038982533,0.10628022,0.0821459,-0.04189112,-0.011551067,0.0025490653,-0.008416089,0.049311016,-0.0990429,-0.073121235,-0.015821923,0.0459144,-0.06685336,-0.049758647,-0.036461093,-0.0035088412,-0.05575102,-0.00025921367,-0.021544427,-0.02748188,-0.017734032,0.06972399,-0.06487478,-0.019859107,0.03110049,0.050297905,0.07244999,0.01881097,-0.06808695,0.072027914,0.04819255,-0.071775585,0.004167412,0.0005075748,-0.024745174,0.025547631,0.04083157,-0.016476631,0.09297478,0.027368667,-0.015409982,-0.023110474,0.002886444,-0.08740083,-0.059923917,-0.06449094,0.1094217,-0.08337872,-0.01974631,0.010809378,0.024095403,0.028376717,-0.062407915,-0.047550097,-0.032840487,-0.02970355,0.03523092,0.06748594,0.019669002,0.01588341,-0.039200723,-0.08160455,-0.0038312415,-0.012214889,-0.07944527,-0.035983287,0.07474687,-0.0051667206,-0.032111883,-0.06225959,0.04557058,0.00018120113,-6.0829908e-33,0.17744777,-0.10425922,0.097836494,-0.06603972,-0.046049885,0.040946856,0.035614405,-0.033981442,0.032509495,-0.06183109,-0.0060419873,0.02051832,0.028679544,-0.042354573,0.018182056,-0.02675335,-0.019173026,0.09446983,0.004124317,-0.008725925,0.013128728,0.115201265,-0.011278187,-0.00022398455,0.05918167,-0.024267357,-0.046505265,0.08928304,0.018519662,0.034300227,0.017017761,-0.014784984,-0.038247153,-0.047053903,-0.070956625,0.010922718,-0.09226052,-0.040801924,0.016835473,0.053784925,0.03580608,0.053538304,0.068310566,-0.061081506,0.02332551,0.072701834,-0.06492484,0.020864887,-0.02161655,-0.0038285877,0.004299388,0.04904221,-0.060729276,0.067603625,0.046867847,0.05977044,0.016606297,0.06283849,-0.025035318,-0.07857557,-0.06312279,-0.14136091,0.052011408,-0.014377519,0.06690921,0.029742748,-0.0025464122,0.01231531,0.014547114,0.039899528,0.03343184,-0.00670015,-0.0021607652,0.01981047,0.009900625,-0.022828214,-0.12689057,0.012568636,0.0031146167,-0.032226358,-0.0077694734,-0.004748186,0.051562358,-0.051163875,0.024721596,-0.024375275,0.062141143,0.05687907,-0.018316437,0.04184533,-0.049903203,-0.037350886,-0.008069424,-0.05302235,0.06578121,-4.6505125e-08,0.025286818,-0.033899643,0.020288443,-0.031062983,-0.009147307,0.030415256,0.008853121,0.011095976,-0.028830806,-0.023005085,-0.02654675,0.061413996,0.004684598,-0.050480846,0.032085948,-0.00018283796,-0.062115323,0.020226663,0.0014350223,-0.016104914,-0.04978839,-0.046379425,-0.14211622,0.10738449,0.044097688,-0.025064753,0.06085041,0.030682454,-0.053457763,-0.011675439,0.016859198,0.0032078633,-0.022935426,-0.05907971,-0.022871772,-0.03599842,-0.05384547,-0.0023985233,0.0150438,0.028404173,0.0019423044,-0.020999147,-0.042943437,0.035834193,-0.0015585974,0.08753311,0.042275548,0.022051984,-0.062168255,0.02203707,0.0687191,-0.047703754,-0.080386005,-0.0691426,-0.1144916,-0.036371958,-0.010679969,-0.039246395,0.013151688,-0.015326303,0.07101117,0.051160015,0.1900385,-0.086670086 +2.7.1.72,"dATP can replace ATP; and dihydrostreptomycin, streptidine and 2-deoxystreptidine can act as acceptors.",384,1.0,-0.08554263,0.001007426,-0.020323927,-0.05879008,0.04672269,-0.06374275,0.015332468,0.06292766,0.05147924,0.0050044153,0.020354105,0.05879775,-0.023727274,0.095312744,0.008977497,-0.015398673,-0.025411148,0.06907784,0.13095738,0.029390426,-0.0424763,0.04198882,-0.044363383,-0.01619156,0.03306162,0.06322962,-0.010113708,0.086394794,-0.09378184,-0.04764378,-0.019332152,0.01552005,-0.0980591,-0.04579236,0.03877917,0.10767849,-0.105140574,0.017488997,0.03263276,-0.055099998,0.019269519,-0.0055255815,-0.06439215,0.0780658,-0.056936312,0.005475537,-0.0074186907,0.065209724,0.012000666,-0.031505257,-0.018067751,0.061953336,0.015093895,0.1106026,0.027338503,0.020415965,-0.053567067,0.05788386,-0.04769444,-0.02213265,-0.05218799,-0.020715745,-0.0009250834,-0.008164027,0.03336944,0.0024798142,-0.013266115,0.008665557,0.022267025,0.034226343,-0.072544284,0.028325126,0.027821941,0.049171917,0.032166548,0.033838086,-0.069172785,-0.033037815,0.07130183,0.0048281294,0.006676486,0.045964558,0.033809315,0.02250798,0.099020466,-0.036787182,-0.004476818,0.015764877,-0.006913269,-0.0038188528,0.04724781,0.021706358,0.019274432,-0.022956077,-0.047808394,0.030247798,-0.014621811,0.0042054025,-0.009784469,-0.020435467,-0.015297988,0.0720302,-0.07797231,-0.030591877,0.0055804215,0.024233388,0.0062786667,-0.0445129,-0.028690346,-0.04483306,-0.024679855,-0.029877326,0.017690884,-0.00014685707,0.03946486,0.035763487,-0.010305282,-0.033349697,-0.041372318,-0.09324069,-0.06597243,-0.074242525,0.014477702,-0.01342699,-0.035934586,0.034950696,-0.023735214,4.8272774e-33,-0.0012360483,0.03272053,0.023756154,0.023667963,0.06066214,-0.002297282,-0.07732807,6.259868e-05,0.015217335,-0.10570291,-0.08011086,-0.12477612,0.020625371,0.018068263,-0.02207734,-0.05665946,-0.078632645,0.12504548,0.082259774,-0.07974567,0.0047757067,0.120816596,-0.011335274,-0.025510559,0.041639246,0.05362697,-0.068547025,0.028985126,0.07402085,-0.024836997,0.010448288,-0.07619913,-0.06298155,0.027671147,-0.029422173,-0.011754038,-0.03345642,-0.06191368,0.07061614,-0.026431184,-0.036424704,0.01830244,-0.026246438,0.050491344,0.050429128,-0.019593956,0.011756696,-0.015116613,-0.05604375,0.014549464,0.09542314,-0.048618693,0.0011371993,-0.14105542,-0.039496664,-0.03614248,-0.009964259,0.0014259311,0.023091463,0.09473788,0.028641036,0.02698141,-0.041811015,-0.03583414,0.02328362,0.049273033,-0.068165675,-0.11121992,0.01772731,0.10630467,-0.02771454,-0.03576829,0.067018494,0.024711065,0.04754729,0.039861538,-0.0044182036,0.07710242,0.010652439,0.044217493,-0.07264626,-0.053425677,-0.07525475,0.057097327,-0.012920076,-0.025974233,0.0024037233,-0.0756531,0.07050269,0.02129312,0.10189307,-0.020342948,-0.048876233,-0.03178869,0.015611829,-4.842314e-33,0.06019228,-0.000578491,0.11042813,0.008486099,-0.015700823,0.06321061,0.0035365312,-0.07356364,0.1259435,-0.059330758,0.022496197,-0.06829286,-0.043057,-0.047677446,-0.0036241508,-0.03831088,-0.0690033,0.042030755,-0.09677043,0.08616237,0.05520569,0.09688794,0.07203947,0.02998693,0.06899584,0.04006327,0.01709221,0.025533605,0.09815747,0.011578113,-0.020774405,0.03643649,-0.076893136,-0.016361963,0.050049115,0.06810149,-0.07097416,0.013548357,-0.06359098,-0.016037634,0.06833446,-0.0135054495,-0.033505995,0.08639223,0.007587958,-0.00818994,-0.011602105,0.07612899,0.019592986,-0.047802374,-0.015844107,0.004762041,-0.06811111,-0.023990072,0.06629636,0.0344441,0.029315878,-0.05859066,0.022644106,-0.03399941,-0.06084253,-0.048601918,0.042889945,0.002203174,0.06873248,0.0172709,-0.015169442,-0.023742527,0.019605605,0.008872512,0.041685015,-0.017977232,0.019851558,-0.008382285,0.04899354,0.021114143,-0.07756765,-0.014997145,0.003859124,0.037712194,-0.08853418,0.05834552,-0.03638042,-0.058096938,0.032954544,0.03821267,-0.011632618,0.004888481,-0.0031749206,0.026995474,0.022603404,0.014278992,0.013053714,0.05953278,0.0045788675,-2.9689991e-08,0.012763432,-0.012661919,0.10365792,-0.060518242,-0.001705626,-0.04871324,-0.037305206,0.018335983,0.047070824,0.023842685,0.059340328,0.10809926,0.073344186,-0.07652038,0.010057801,0.023283426,-0.053516712,-0.035564993,-0.035525497,-0.058951654,-0.107897334,-0.006359386,-0.08063111,0.079068094,0.07921783,0.0017672959,-0.030713515,-0.00754955,0.055086605,-0.06644983,0.086455606,-0.052824274,0.041023254,-0.014288924,0.05943587,-0.050669584,-0.064515784,-0.0065987464,-0.066457435,0.021452777,-0.053234044,-0.021879604,-0.066216916,0.038357068,-0.075861305,0.023390701,-0.007847999,-0.0016739034,-0.10813346,-0.0379451,0.036327094,-0.028765975,0.0104680555,-0.07175504,-0.064861074,0.02920439,-0.014402966,-0.039540816,-0.02891523,-0.05265553,-0.043831244,0.036719944,0.163117,0.014609516 +2.7.1.74,Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors. ,384,1.0,-0.073754884,-0.04168883,-0.005388869,-0.061009582,0.006767775,0.0044909273,0.058749057,0.017852213,0.030459886,0.036113802,0.06998896,0.027356805,-0.036050525,0.06509534,-0.012260362,0.0039523733,0.01891509,0.089092046,0.024782501,-0.0037685586,0.015226105,0.019543875,-0.010427067,-0.03784602,-0.014493699,0.03470917,-0.003089416,0.007873328,0.0102318665,-0.0913774,-0.072147705,0.0095945215,0.014583239,0.022328394,0.008784098,0.10697133,-0.08115888,-0.0027852275,0.014306842,-0.02562534,0.13556007,-0.0245879,0.121902175,0.030637411,-0.03533134,-0.023989046,0.0041288366,0.0013275668,0.056533482,-0.008807898,0.043290745,-0.027417174,0.018866079,0.034998093,-0.055229478,0.072861105,-0.09882648,0.018276084,-0.004248187,-0.029302008,-0.013304578,-0.041902583,-0.031639673,-0.038213555,0.09437841,-0.025566688,0.077996045,-0.020057626,-0.008934609,-0.013342846,0.06904165,-0.0048464937,0.009544027,0.027245492,0.020506538,0.090360545,-0.03233118,-0.04857093,-0.026819974,0.026004795,-0.029553073,0.030606357,0.07550986,-0.0014525243,0.012076112,-0.0019589493,-0.052799847,0.1204136,-0.02981491,0.08214104,-0.008374873,0.04079751,0.06716615,-0.05180415,-0.04125076,-0.038514744,0.012180216,0.026486982,-0.02975494,-0.047737487,0.03545586,0.11751711,-0.056183606,-0.08832727,0.0017956381,0.04722978,-0.04432695,-0.08943454,-0.0006691914,-0.04275984,-0.07610702,-0.022167865,0.035084557,-0.011926176,-0.042690914,-0.00055117527,-0.0372081,-0.07592587,-0.033710226,-0.11663601,-0.03637519,-0.06877472,-0.011408611,-0.003768413,-0.045506656,0.019288246,-0.12297175,2.434253e-33,-0.033437327,0.008093169,0.037151586,0.00707614,-0.08061231,0.02601991,-0.0072117704,-0.056181576,-0.098052554,-0.08792559,-0.09801969,-0.054389987,0.10682774,0.055513054,-0.092402734,0.009766648,-0.02020913,-0.023666283,0.07344545,-0.026919492,0.029111164,0.090236366,-0.07682193,-0.010858271,0.027056342,-0.025259335,-0.029409042,0.011610075,0.11795632,-0.022119619,0.019294849,0.0046743224,-0.04506463,0.039921936,0.016217018,0.006986833,-0.025181616,-0.003868193,-0.009807888,-0.048893947,-0.060496397,-0.0058784606,-0.02310546,0.036537975,0.061285604,-0.012018649,-0.029751457,-0.06366611,-0.054470744,0.064885676,0.013326906,-0.060973495,0.010694707,-0.061699495,-0.031981908,-0.027691064,-0.022445919,0.041650757,-0.07441368,0.08807864,0.022452112,0.052244764,-0.059708767,-0.02632883,-0.05358765,0.09428064,-0.06961111,-0.09840036,-0.052519012,0.06198496,0.013218811,-0.04414703,0.01569533,0.10154895,0.018069841,-0.014784012,-0.0015645014,0.011013738,0.022715902,0.08113277,-0.0051975017,-0.0650049,0.016635511,0.044788536,-0.07079635,0.020785363,0.05043238,-0.055773746,0.041668165,-0.04870771,0.104760535,-0.0788597,-0.0087088635,0.008931031,-0.0025830062,-3.8925584e-33,0.100134365,-0.04113756,-0.013469249,-0.0023869255,0.00016119579,-0.01637216,0.046592116,-0.10621769,0.090961464,-0.036162023,0.10084366,-0.044168457,0.024546223,-0.020753613,0.017348872,-0.026664319,-0.022472417,0.029698726,-0.06431363,0.03351916,-0.086918496,0.11126229,0.045732412,0.035795987,0.04829275,-0.006798036,-0.03772016,0.090305574,0.030300582,0.022512408,-0.046702806,0.049375508,-0.09731845,-0.09798216,0.010849927,0.04130811,-0.06669003,-0.026160879,0.015554251,-0.0008887847,0.0056249187,0.039487943,0.029031044,0.12035806,0.020679733,0.05545255,-0.00093442126,0.038442202,-0.041767336,-0.046833064,-0.0427714,0.060536988,0.029111292,0.06520828,0.12436628,0.081232056,0.07204385,0.014581335,0.04729877,-0.030138317,-0.034099787,-0.08738567,0.024511749,-0.048942223,-0.021539493,0.04467969,-0.0041388497,0.06460804,-0.022406138,0.027031627,0.05738078,0.04900678,0.029009314,0.014725473,0.00034941282,0.013302873,-0.07883058,-0.03989588,-0.0266041,-0.07399409,-0.03137637,0.031076986,-0.03885043,-0.008370794,0.13861495,-0.04111682,0.041572984,0.011638156,-0.051481932,0.032800026,-0.028768571,-0.05684265,0.033215284,0.11148488,0.0074586943,-2.9427156e-08,0.04209244,-0.017216014,0.00041029116,-0.10705791,-0.044487137,0.083260186,0.006605597,0.027729947,0.023615127,0.045757674,-0.0501027,0.058525406,0.0074127694,0.028990228,0.033036493,0.03915447,-0.031761166,0.0010690619,-0.029891428,-0.039552208,-0.089710645,-0.009755897,-0.1055131,0.06932401,-0.025935106,0.05467291,0.10094515,0.009803541,-0.0001341865,-0.040341754,0.031701487,-0.037278146,-0.0059969705,-0.05574543,0.040970083,0.050059848,0.0028289848,-0.011030419,0.0008453153,-0.0071458137,0.00057975925,-0.024749765,-0.13231696,0.030325502,-0.009397433,-0.043117184,0.038650494,-0.012615163,-0.039191794,0.011063209,0.072280556,-0.049235173,-0.0117991315,-0.017841458,0.009295077,-0.030413287,-0.002015229,-0.006978395,0.052213624,0.026847173,-0.04931903,0.00031333163,0.10756139,-0.036877017 +2.7.1.76,2'-Deoxyguanosine can also act as acceptor. Possibly identical with EC 2.7.1.74 deoxycytidine kinase.,384,1.0,-0.08139394,-0.032982588,-0.05294985,0.01236639,0.044938937,-0.10412272,0.017866159,0.04670017,0.021672634,0.024887465,0.102689475,-0.07035958,-0.03263939,0.08025381,-0.019758103,0.08347205,-0.07899415,0.014514603,0.021672796,0.03142605,-0.05418345,0.06823863,-0.038947314,0.038683616,-0.056897435,0.017402949,0.0285154,0.107556194,-0.028067285,-0.10981242,0.012840306,-0.02641552,0.043141443,0.024722677,0.011431432,0.025159579,-0.060510002,-0.059888642,-0.019232694,0.01889997,0.026365496,0.03469561,0.012494339,0.016187426,-0.02582788,-0.038833115,-0.029822735,0.018094646,0.042406805,-0.018152896,0.040152263,-0.005774577,-0.047630206,0.063681476,0.014522068,0.0683194,-0.147008,0.04865538,-0.024340298,0.01313053,0.032571472,-0.02315897,0.013241756,0.0068824347,0.027396472,-0.0037813087,0.095172174,-0.090087615,-0.05842898,-0.027985925,0.0027791716,-0.05356274,0.06942934,0.025271473,0.031868905,0.024031315,-0.06035249,-0.016629023,0.018362857,-0.013652417,-0.016800916,-0.08871103,0.0061197053,0.010434906,0.005447416,-0.011553712,-0.051028393,0.005764315,-0.013528029,0.062452305,0.068270676,-0.02835437,0.09901202,-0.03931379,0.042787824,-0.010997957,0.07910191,0.1055617,-0.039253727,0.000851147,-0.039210647,0.074392214,-0.123420626,-0.021457782,0.038069222,-0.013529079,0.06958557,-0.06131269,-0.018328777,-0.052742984,-0.022783475,-0.06383676,0.094869904,0.046322662,-0.01294364,0.11199053,0.023235532,-0.028876092,0.08086277,-0.032277483,0.02338552,-0.040675435,-0.014631139,-0.00632922,-0.058212154,0.07015411,-0.04619052,2.3146143e-33,-0.013313735,0.035588104,0.05899457,0.01693029,-0.016548665,-0.0155741535,-0.06362318,0.022880422,-0.037210684,-0.08983505,-0.17696007,-0.00858064,0.14044183,0.05781446,-0.07648141,-0.06707557,-0.039637487,0.028274264,0.048713516,-0.0067985454,0.058889017,0.06361072,-0.03134494,-0.033261117,-0.000403515,0.0383946,-0.05946677,0.0011634912,0.07826864,0.014796345,-0.049505003,-0.05521045,-0.02227514,0.0874477,-0.019148601,-0.0027442328,-0.024503997,-0.0047688247,0.02308973,0.014931492,-0.03332152,-0.027785556,-0.07936672,0.0037830262,0.044137828,-0.029161958,-0.02595068,0.01961457,0.015981605,0.033102587,0.016658997,-0.054822885,-0.02079734,-0.10322344,0.0068935975,-0.050392203,0.026943741,0.011645692,0.027748825,0.05864496,0.018193642,0.07452838,-0.03624691,-0.0067808996,0.019348139,0.029188374,-0.13041022,-0.09011674,-0.050396465,0.007905985,-0.018479984,-0.029222755,0.08283149,0.024061918,0.05405069,-0.016214693,-0.042822693,0.067185506,-0.004333753,0.03965978,-0.085937575,-0.06891108,0.0022658177,0.028463412,-0.050439846,-0.012286991,0.036171284,-0.04636834,0.023026854,0.096656665,-0.03089172,-0.0024085206,-0.09041169,-0.032055914,0.11156134,-4.133055e-33,0.047455367,-0.0060081105,0.027574738,-0.018426742,-4.2952015e-05,0.09457078,0.032880053,-0.010537534,0.11105838,-0.054462817,0.1536318,0.025364824,0.024011757,-0.024561942,0.022061227,-0.019116802,-0.09007599,0.054182947,-0.02004165,0.0067188647,0.023264376,0.012354882,-0.016445844,0.04600375,0.042914405,0.00086879043,0.018310498,0.005360982,0.031005278,0.04249579,-0.12748122,0.015390063,-0.025995398,0.014587044,0.0078545725,0.03954185,-0.1053534,-0.019972991,-0.10244362,-0.05282214,-0.083546855,0.018883536,-0.017118238,0.12162449,0.034852758,0.057959307,0.061242748,-0.0029713828,-0.029861901,-0.066788085,-0.029476846,0.03580091,-0.055578284,0.048673604,0.053414613,0.055949613,-0.020518914,0.007084698,0.015871815,0.015688794,0.014564772,-0.06423454,0.020814508,-0.03310729,0.058592774,-0.017900854,-0.08584152,0.074687265,0.0503481,-0.021376776,0.0685393,-0.060681593,0.009980477,-0.012125024,-0.04727865,-0.026387425,-0.07136152,-0.0653616,0.011361353,-0.052249398,-0.08179763,0.036917534,0.038542427,-0.0016193109,0.015814178,-0.0052933143,0.019929942,0.01514755,-0.0756553,0.00031734546,0.0041755205,-0.0022738262,-0.10141539,0.061537333,0.041662704,-3.172403e-08,0.015259516,-0.06589007,0.04750566,-0.041452795,0.0068848883,0.038786422,-0.0052817636,0.074724436,0.030742424,-0.01962869,0.019857753,0.09180523,0.06915321,-0.027635835,0.027015626,0.044718493,-0.069144025,0.019362843,0.0006747283,0.005018631,-0.047635276,-0.06644579,-0.020663427,-0.04942605,-0.013556854,-0.018768474,-0.022589924,0.108101994,0.0101620685,-0.087216154,0.060549732,-0.063532814,0.013908114,-0.07465351,0.016432246,-0.012314562,-0.03384556,-0.05300256,-0.008094791,0.019891607,0.011547155,-0.040816333,-0.05132435,0.055716667,-0.0032839342,0.037864845,0.0878782,0.020873941,-0.025825456,-0.049825616,0.051763777,-0.047099914,0.01946438,-0.033266183,-0.022777308,0.0035848387,-0.05394899,0.0064896713,-0.015143799,-0.033653848,-0.0020493795,0.051494043,0.13831088,0.0063303453 +2.7.1.77,"Phenyl phosphate and nucleoside 3'-phosphates can act as donors, although not so well as nucleoside 5'-phosphates. Nucleosides as well as 2'-deoxyribonucleosides can act as acceptors. ",384,0.99999994,-0.10334797,-0.08133951,-0.0073375558,-0.10700978,0.044575505,-0.038252614,0.011676712,-0.042866167,0.01875456,0.043197285,0.054160357,0.027553376,-0.08213879,0.13633513,0.008349253,0.046327654,-0.09347867,0.104374416,0.0022836125,0.024782786,0.043861438,-0.006869799,0.008848937,-0.022553146,0.03434267,-0.0038738947,0.031603813,0.008813429,0.008577928,-0.07567218,-0.0466676,-0.06571916,-0.037853792,-0.045555837,0.032592442,0.07809024,-0.103860624,-0.0025279261,-0.023937067,0.031918935,0.061847076,-0.08340459,0.02340563,0.040471364,-0.10435019,-0.03428408,-0.0050388286,0.02372511,0.01311543,-0.03690264,-0.0055424473,-0.0011032021,-0.029108291,0.025621096,-0.045550343,0.08129533,-0.051119823,0.044701252,-0.0014715123,-0.003063725,-0.0011726024,-0.018078638,0.0063899043,-0.024325028,0.06472781,0.021841714,0.058909606,-0.008571402,-0.0340701,-0.0006169238,0.087829344,-0.035780318,0.0736047,-0.010400509,0.06332048,0.096859865,-0.06397124,0.0007592265,-0.011334863,0.04896894,-0.04649122,-0.023234028,0.07297026,-0.019921042,0.048532814,0.0036859254,-0.13437487,0.04625229,-0.03486953,0.057931058,-0.022958163,0.008204538,0.041068196,-0.024616515,0.03609822,0.021066364,-0.0032978994,0.024533646,-0.00420363,-0.03265603,0.0044699097,0.12678663,-0.05516382,-0.04267396,0.017082563,0.019947253,-0.022960106,-0.101742834,-0.014394858,0.049732592,-0.020454854,-0.0260347,0.043625105,-0.040330615,-0.035005756,0.011691885,-0.077694535,-0.07002902,-0.05212789,-0.07736445,-0.04009627,-0.04618584,0.019069215,0.008510381,-0.040434357,0.0627074,-0.07115911,6.531895e-33,0.025553443,0.03141039,0.0031572299,0.07027415,-0.07849833,-0.0066108163,-0.012001601,-0.052500978,-0.080579504,-0.08278595,-0.10289462,-0.07034259,0.121542394,0.017431224,-0.07419936,-0.009807094,-0.014645144,0.044959743,0.053139776,0.009642677,0.070911616,0.057522118,-0.034723468,0.05073572,0.053852744,-0.0061702575,-0.120523445,0.05755862,0.06970989,-0.033543043,0.057203256,-0.07431157,-0.030060567,0.032252975,-0.025887813,-0.025892531,-0.05772825,-0.008342174,-0.006813588,-0.01836033,-0.015652834,-0.0059345863,-0.01361696,0.058605652,0.03671852,-0.01760582,0.03267353,-0.08590792,-0.09058731,0.05303761,0.000824471,-0.065911494,-0.014122684,-0.06741598,-0.006847014,-0.0889347,0.058237072,0.0010883366,0.0044971853,-0.0031882909,0.028594138,0.03402283,0.04421201,-0.036708668,-0.0016119005,0.0344555,-0.028342066,-0.060368545,-0.023086963,0.04092597,0.015300221,-0.020167472,-0.045667816,0.022344153,0.036354918,-0.02593106,0.03560095,-0.0016136912,0.006357943,0.034198057,0.03963953,-0.11232154,0.009954884,0.011351068,-0.06320793,-0.04098538,0.0048299497,-0.16167514,0.076498,-0.0300082,0.07306525,-0.063799106,-0.050251383,-0.0664838,0.030919952,-7.128294e-33,0.094274625,-0.021861685,0.05998075,-0.007640485,-0.04222937,0.025342848,0.014746953,-0.09409584,0.104861185,0.0055993255,0.037741143,-0.029771889,0.05713767,-0.03733633,0.006324392,0.038691666,-0.0059883255,0.0031515092,0.021492535,-0.0029327685,-0.022809045,0.097215794,0.04688674,0.036698557,0.012076668,0.034369767,-0.028898122,-0.056121908,0.072210416,-0.012818335,-0.04776552,0.026623609,-0.040504772,-0.037887093,0.014983062,0.030290054,-0.027137192,0.013257912,-0.012656966,-0.032985047,0.033478115,0.021307807,0.048649836,0.08367975,-0.060515046,-0.041896462,0.056978814,0.020495761,-0.0069337757,-0.07871697,-0.034286864,0.06273275,-0.0059236973,0.03363934,0.096824236,0.06987429,0.06815115,-0.011934371,0.048174262,-0.069483995,-0.05175974,-0.08563156,0.035715975,-0.011539946,-0.002866964,0.03611374,-0.005207139,0.08440162,-0.0020783877,0.0010603116,0.021453628,-0.00061875297,0.07096991,0.044171687,-0.03519141,-0.051723547,-0.054475702,0.031480372,0.04180327,-0.074112624,-0.06472215,-0.009349524,-0.0017017358,-0.032440085,0.10845774,-0.06753107,0.09278681,-0.014947684,-0.061265416,-0.0035755213,0.014034551,0.009688676,0.07971754,0.106127344,0.068714246,-3.7188105e-08,0.059235066,0.009163586,-0.025462361,-0.054873247,-0.009455443,-0.026414609,-0.01747573,0.034189492,0.024049444,0.07654665,-0.026706843,0.06484204,0.026392631,-0.0067684874,0.12077931,0.04974051,-0.06020957,-0.036957964,-0.03733453,-0.0826545,-0.061865747,0.014680766,-0.08563044,0.03686998,3.5456425e-05,0.1022087,0.04983149,-0.0012350846,0.01424932,-0.021487433,0.02483897,-0.0122702075,-0.043079212,-0.081908,0.05746736,0.039076608,0.02736722,-0.017225673,-0.0570824,0.028331932,-0.07607109,-0.058071494,-0.09722363,0.054660723,-0.03576211,0.053165052,-0.012019657,0.022586374,-0.04857198,-0.011017093,0.039722815,-0.064412236,-0.009316187,-0.038302746,-0.05290943,0.015360088,0.02965053,0.06814578,0.085053526,-0.028621893,-0.021183839,0.018912908,0.118699804,-0.06605936 +2.7.1.78,Also acts on 5'-dephospho-RNA 3'-mononucleotides. ,384,1.0,-0.062072124,-0.10170502,-0.0017829121,-0.07193987,-0.014779238,-0.0494982,-0.03410789,0.01514932,0.028232425,0.115817524,0.025147779,0.014868975,-0.1328868,0.060178407,-0.009418894,0.11463377,-0.11793478,0.047959648,-0.008778262,-0.0064832093,0.09721555,0.04894183,-0.030956442,0.026086312,-0.013965007,0.040653225,0.009398695,0.06945089,-0.013486563,-0.051463734,-0.056934893,-0.029385896,0.035373818,-0.0019512614,-0.013514049,0.061749183,-0.04955899,-0.04779572,0.055620216,0.07193327,0.09509616,0.0036719842,-0.021793535,0.025481073,-0.026933981,-0.003739294,-0.10813975,0.05971546,0.04475827,0.022639774,0.009313014,-0.029261531,-0.034110244,0.032778885,-0.01874433,0.062138192,-0.069257565,0.007382406,-0.007503292,-0.03958719,-0.028853228,-0.01527702,0.032659966,0.03431596,0.11297278,0.0042676483,0.08913482,-0.051208675,-0.050071515,0.05471292,0.043109726,-0.031454828,-0.0060067764,0.027455095,-0.043253466,0.025931476,-0.005469698,-0.031947866,0.0023542198,-0.024473555,-0.060902715,0.04655038,0.06939724,0.028610498,-0.060172345,0.024532722,-0.0632043,-0.007854271,-0.09516032,0.05903602,-0.025431361,-0.07412441,0.013801244,-6.760808e-05,-0.036671367,0.023346854,0.020920044,0.021488508,0.0019685116,-0.045820612,0.01860469,0.07215893,-0.060664695,-0.0056534777,0.0057639023,0.037509527,0.04654766,-0.04088479,-0.064363,0.020028984,-0.029125249,-0.03467433,0.034636416,0.017439757,-0.06171221,0.022813737,0.0023550026,-0.028186033,0.044775624,-0.002000101,0.05415256,-0.056249954,-0.041205917,0.039829355,-0.10226907,0.069676116,-0.047316276,-1.5688734e-33,0.0022573257,-0.04105381,0.040311333,0.070225485,0.054728866,0.0371247,-0.025189674,0.0066752327,-0.11648126,-0.0006392428,-0.040736567,-0.022278287,0.1168479,0.019333199,-0.033851027,-0.00083027186,-0.038967643,0.082152896,-0.089039505,-0.04207367,0.051732764,0.040860876,-0.06483587,-0.031257026,0.0031696071,0.0314797,-0.07345943,-0.0056296294,0.09140106,-0.022990227,-0.032625567,0.009489045,-0.038126614,0.010535697,0.10036293,0.013279021,-0.017203849,-0.039724857,0.00032604532,0.09205737,0.06253941,-0.062590614,-0.09301536,-0.040773597,0.06170491,0.0069188126,-0.066333525,-0.014429074,-0.05884169,0.0063611288,0.10330748,-0.039740365,0.054323424,-0.0526219,0.038003616,-0.039938197,-0.05723262,-0.06603821,0.011665911,0.05122802,-0.055288248,0.019939573,-0.0109931575,0.020744992,0.01758933,0.008980316,-0.098305315,-0.084501185,0.009942309,0.0768618,-0.004804028,-0.038407657,0.05344615,0.059461854,-0.04848309,0.040399794,-0.014166876,-0.010243782,-0.057396002,0.12913841,-0.004728962,-0.094408356,0.02949092,-0.06000024,-0.015871096,0.00745489,0.07143084,-0.15716112,-0.039215766,0.03780065,0.117676675,-0.040399417,-0.06457605,-0.060089577,0.0119420625,-2.411834e-33,0.015552444,-0.08085182,-0.0033580123,-0.033705335,-0.111494444,0.0957661,0.0042587947,-0.030957056,0.03809985,-0.0011559846,0.060794882,0.06918548,-0.009134708,-0.05318886,0.027900102,0.017537817,0.03029349,0.021740867,-0.038953528,-0.006903453,0.118706726,0.08180205,-0.0004646037,0.09325691,0.0636414,-0.03152043,-0.01065615,0.0038275358,-0.06217886,0.02646994,-0.07099855,-0.032646228,-0.008216798,0.015868608,0.014311549,-0.010051553,-0.04343502,0.0241136,-0.01415474,-0.04738483,-0.05736652,0.028703561,0.083611175,0.06616491,-0.006913473,0.046185516,-0.0046200925,0.030277167,-0.016479209,0.025069367,-0.0021169202,-0.07288438,-0.014762327,0.060290944,0.042586237,-0.041437965,-0.021199489,-0.0059421505,0.019666126,0.03820209,-0.036491986,-0.032829996,0.021956395,-0.022057477,0.08023208,0.055344958,-0.011148121,0.024593867,0.066918366,-0.09526717,0.02839203,0.025928134,0.057038125,-0.013084988,-0.050772075,-0.062157966,-0.0901168,0.0009071562,-0.008537574,-0.04046252,-0.085880145,-0.016259935,0.032094143,0.03241574,0.00057542475,-0.07447656,0.06099974,0.12460836,-0.053870324,0.045589317,-0.03794813,0.019805972,-0.025559569,0.021641891,0.03296209,-2.4411525e-08,0.064310916,0.008709454,0.025425736,-0.064334005,0.007718623,0.04192933,0.010737711,0.06443981,0.07127219,0.047256276,0.053946465,0.013502808,0.04790218,0.024062222,0.1465571,-0.026572818,-0.03515085,-0.013427383,-0.020976689,-0.051655285,-0.1179438,0.0257181,-0.058301907,0.042190313,-0.029526621,-0.003895213,0.0475112,0.025419235,0.032152444,-0.07252825,0.03489739,-0.0062286444,0.007904409,-0.06401759,-0.050298866,0.020453066,0.010849289,-0.02181231,-0.038382847,0.04039792,-0.05166811,0.008634068,-0.0007477434,0.012746508,-0.09461585,-0.014197148,-0.017249184,0.053618044,-0.024922526,-0.032724753,0.032599393,0.008951605,-0.006521683,-0.0031811944,-0.106066644,-0.03541083,-0.021056654,-0.033068225,-0.018228266,0.027538592,0.013991615,-0.001559476,0.16178338,0.0074205496 +2.7.1.79,May be identical with EC 3.1.3.9 glucose-6-phosphatase.,384,0.99999994,-0.08574126,-0.044574488,-0.08102278,-0.039432507,0.06617521,-0.051180243,0.0008759717,0.026968447,0.04097837,-0.021953499,0.019096209,-0.02620397,-0.110915095,-0.013677346,-0.0037742364,-0.07804749,-0.057560347,-0.072689064,-0.009624344,0.044700187,0.06599047,0.03755189,0.05305274,0.055896614,0.07457691,-0.010941726,0.08511915,0.05258321,-0.04169036,-0.07047188,-0.027587952,-0.023915475,0.04125057,-0.012464011,0.0068807644,0.087921865,-0.032503653,-0.10088227,-0.037983943,0.0028060186,0.063519984,0.02255181,0.047691196,-0.029256467,-0.0057000467,0.0155182155,-0.0997125,0.069706224,0.07364278,-0.033663128,-0.027326945,-0.12508719,-0.055524465,0.008413841,0.028615719,0.02319233,-0.114491105,0.026232637,-0.01880909,0.0042135934,-0.09401243,0.014250129,0.086472236,0.06202076,0.07994034,0.0009913848,0.026627818,-0.17561649,-0.062078055,0.02114355,-0.059600048,-0.060878664,0.039696615,0.025328806,-0.0127880545,0.09223686,0.002589091,-0.011968902,-0.034656305,0.004124836,-0.033683077,-0.040925093,-0.03568069,0.045895897,-0.019268576,-0.07021133,0.029951993,-0.0125522595,-0.04938477,0.019523328,0.013705391,-0.007601683,0.03638235,0.025094226,-0.056329947,0.06150925,-0.005545082,0.07371987,0.09818535,-0.024861837,-0.016377188,0.114013635,0.0035527446,0.019012284,0.012437146,0.037360117,0.016231123,0.071965724,-0.056686964,-0.009777414,0.014352424,-0.012304214,0.02957689,0.038275663,-0.061083317,0.048784778,-0.04667652,-0.05406672,0.01087338,0.08908335,0.05624969,-0.06454044,0.042421795,-0.030236624,-0.052861862,0.06709905,-0.080812104,-1.9377066e-33,-0.004756232,-0.0307672,0.07468837,-0.08069341,0.007261033,0.063803084,-0.08170419,0.008727963,-0.062507465,-0.058956273,-0.06737541,-0.0031197954,0.06096289,0.011172712,-0.059902396,-0.030528799,-0.051916525,0.0711884,-0.011923955,-0.0034200407,0.06392468,0.006566986,-0.009652206,-0.017424276,0.031905744,0.048626624,-0.08088335,0.016511286,0.04045437,-0.0016480219,0.019116083,-0.033211783,-0.022225417,-0.011626326,-0.06795783,0.03153187,-0.019468438,-0.054851424,0.0058742156,0.04076463,0.06276645,0.031473707,0.03094975,-0.048485875,0.026023814,-0.028329557,-0.05062486,0.05252699,0.119276516,0.05026526,-0.051793247,-0.039518747,0.10234988,-0.032769516,0.06156697,-0.0389445,-0.04794662,0.040706404,0.019708533,0.054143958,0.051738016,0.14245808,-0.02956338,0.045175895,-0.027579261,0.049047425,-0.064282,-0.015716052,-0.055806182,0.03760834,0.0040294337,-0.05737593,0.029324278,0.04506255,0.011432197,-0.060051072,-0.053290118,-0.0059080822,-0.083822355,0.002755118,-0.012526124,-0.0014602316,0.013691258,-0.0029954999,-0.14379601,0.07009051,-0.03918508,-0.0035207097,-0.026023237,0.02907541,0.06987507,-0.0066042696,-0.08488976,0.006964601,-0.06575401,-1.2449208e-34,0.03792139,-0.054490626,0.09432193,-0.06304928,0.028791966,0.047371067,0.10268128,-0.020048873,0.041229483,0.0023630676,0.10814841,0.019560963,-0.018937752,-0.11980661,0.0437913,0.026633186,-0.06396888,0.011830914,0.03698936,0.01518739,0.006604307,0.0818868,-0.05859102,0.03574585,0.041234992,0.024325434,0.014900014,0.042158917,0.0049492647,-0.0433541,-0.07315592,0.0067782397,-0.047696594,-0.013026587,0.009070591,-0.02061177,-0.060175907,-0.08985065,0.00981917,-0.030056592,-0.0007133735,0.051957946,0.07709638,-0.019655585,0.0847949,0.080513865,0.044755224,0.040651403,0.010133153,0.038305584,-0.050196458,0.0003615575,-0.04803441,0.061050776,0.01611334,0.018839477,-0.015610175,0.031680632,-0.040425595,-0.009089606,0.03603059,-0.04373747,0.03403448,-0.007166835,0.034688145,0.03716362,0.017281786,-0.0034781878,0.06345844,0.08357829,0.037314706,-0.037930842,-0.034835912,-0.04056998,-0.016462853,-0.030474968,-0.08211048,0.06557701,0.002470257,-0.04626127,0.052675206,0.04157407,0.007118019,0.028737837,0.026071422,0.0067385347,-0.0035757998,0.0166904,-0.034327555,0.057142295,-0.05814866,-0.022938792,-0.1151405,0.014955673,0.027220313,-2.2732753e-08,0.15832828,-0.08999012,0.038948223,-0.0004080898,0.044038534,-0.047028013,-0.0032584476,0.031856887,0.010838978,0.020427838,-0.013838587,0.024942668,0.06217649,-0.06225173,0.024088811,-0.05350442,-0.10697825,0.029590426,-0.01021604,0.040957935,-0.047427196,-0.010958299,-0.06884706,-0.0036323771,0.023933852,0.050467037,-0.003682941,0.03630793,-0.053398,-0.053507283,0.04622232,0.016508393,0.0317316,-0.028201248,-0.04521702,-0.012292292,-0.04781228,0.0016371411,-0.07579054,0.04636269,-0.014670536,-0.086902425,0.00247941,0.01094591,-0.0077591697,0.038865384,0.04303059,-0.0145146595,-0.01992577,-0.061883043,-0.0071379696,-0.026551241,-0.047897343,-0.027129937,-0.043272145,-0.06398902,-0.060220983,-0.043639466,0.007811296,0.028053613,0.10024258,-0.0039343275,0.16261233,0.009808616 +2.7.1.81,Both the natural 5-hydroxy-L-lysine and its 5-epimer act as acceptors.,384,1.0,-0.029263249,-0.13548908,-0.0033805715,-0.00079871685,0.15200594,0.035215423,-0.014415057,0.0022705772,0.008905543,0.012580859,0.060201827,-0.0194241,-0.050613645,0.047584206,0.010479825,0.07384272,-0.09100109,-0.06625312,-0.011199352,-0.004136032,0.02351427,0.009202062,-0.0048532085,0.04025786,-0.024772437,-0.02433879,0.012088259,0.0061032646,0.01301561,-0.10766881,0.000445399,-0.00662585,0.009119326,-0.026630083,-0.08066155,0.04413181,-0.061078534,-0.014181612,0.052873667,0.036643773,0.02326306,-0.08614529,-0.021708282,-0.010454617,-0.058901865,-0.012840699,0.010596908,0.038976982,0.018977141,0.027563062,0.029704923,-0.046439476,-0.095524065,0.061599102,-0.10291252,-0.0021564853,-0.1562564,0.0261217,0.006406959,-0.0060484284,-0.01565924,0.030617384,-0.029666446,0.016174996,-0.012270127,-0.010860952,-0.028076842,-0.049432423,0.0044194898,-0.02496876,0.005608703,-0.05411944,0.04939047,0.07531067,-0.005954119,0.009211495,-0.026267897,0.011275256,0.035667587,0.025406692,-0.10095419,0.02412921,-0.0088535035,0.07172177,0.06195657,-0.041483484,-0.057887733,0.07988666,0.026561964,-0.053973388,0.091514945,-0.0519737,-0.036203798,0.045640495,-0.013929133,-0.017999332,0.023474963,-0.025337067,0.008190737,-0.03984885,-0.038078062,-0.016456096,-0.075305425,-0.006619517,-0.064043656,-0.006790813,0.020946793,-0.023714745,-0.03079801,-0.050060708,-0.03383684,-0.042674232,0.067660585,0.037982475,-0.024309084,0.0498968,-0.035122383,-0.05086378,0.06160756,-0.092849754,0.0035757362,0.05493925,0.075284705,0.027108055,-0.08026647,0.059879184,-0.015689597,-2.0514762e-33,-0.035401717,-0.0057967408,0.043371703,-0.03360601,0.020778757,0.101655215,-0.0879736,0.019107947,0.07099714,-0.049589448,-0.08130073,0.006275874,0.07797516,0.059671603,-0.020660104,-0.030757671,-0.063127026,0.023031468,0.07219575,-0.00937358,-0.022901969,0.064360514,-0.06880301,0.03565617,-0.06892251,0.036331832,0.04317734,0.039223254,0.06372367,0.006934071,-0.025492555,-0.08192632,0.040986996,-0.0003323123,-0.0056581353,0.0669604,0.050538063,0.014504587,0.0123212915,-0.015237891,0.05167033,0.020151434,-0.058493674,0.040659223,0.061581362,-0.04456411,-0.08021525,0.014732184,-0.0625774,-0.010187554,0.06746646,-0.06420017,-0.015968056,-0.050496385,-0.056093782,0.035064038,-0.03125388,0.056599353,-0.037264362,0.05454362,0.056463555,0.14758003,0.06126717,-0.03785612,-0.019501954,0.052651167,-0.019457031,-0.08958894,-0.0248906,0.0379769,-0.06289405,0.029970808,0.122152895,0.08603376,0.0479645,-0.034869432,-0.04048307,0.043023642,0.02637581,0.031535417,-0.046082713,-0.052124448,0.0057351417,0.16810648,-0.052575555,-0.036961768,-0.0009633653,-0.048031244,0.058523063,0.03101805,0.052362558,-0.07381987,0.04524256,0.039723396,-0.016245529,1.8476226e-35,0.051335897,-0.11215287,0.09263739,0.0624153,0.032981686,0.03838984,0.061428305,-0.06608705,0.13351981,0.009803788,0.098896526,0.019538535,-0.004306541,-0.013089629,0.04692215,0.035210386,-0.016326213,0.08975316,-0.018994445,0.016588077,0.02695025,0.010686121,-0.003503959,0.00997784,0.052459333,0.063985564,0.0033686142,-0.011692266,0.02279394,0.0425065,-0.036032457,-0.047208577,-0.03148264,-0.10631408,0.009856956,0.01974029,-0.04320855,-0.018910618,-0.060483243,-0.074085884,-0.013414499,-0.012658943,0.029681545,0.07247417,0.00265281,0.04151256,0.018824162,-0.014306653,-0.052408684,-0.009583107,-0.019039864,-0.025568508,-0.035214573,-0.010905505,0.0102424435,0.022808451,0.02114787,-0.010481705,-0.01958962,0.015354135,-0.030466236,-0.025622495,-0.009853896,0.0026203536,0.024000736,-0.035033006,-0.04012409,0.04200425,0.013517956,-0.04411636,0.07027106,-0.04358079,0.036799222,0.080103315,0.041593052,0.040315717,-0.004255432,-0.13066296,0.002291543,0.0034525003,-0.096288204,0.015861142,-0.030303018,-0.032982446,-0.0355435,-0.016323105,-0.040323835,0.052451238,0.06832771,0.076331064,0.017552732,-0.036921296,-0.029728152,0.00014824243,0.13761349,-2.5338068e-08,0.036804393,-0.07779721,0.030055469,-0.053293817,-0.075715266,0.012910523,-0.0089612575,0.012669326,0.030982632,-0.043007176,0.07045485,0.06987352,0.016285228,0.011499766,0.027369782,-0.021190897,0.011487121,0.081128575,-0.026544793,-0.006217293,-0.0905624,-0.033763174,0.054900445,-0.08948917,0.0072733294,-0.065956056,5.8356152e-05,0.035431042,-0.03361913,-0.02206768,0.05360122,0.011407322,0.004644325,-0.035425868,-0.010920904,0.095683105,0.009487266,0.011655052,-0.044015698,0.067040324,-0.049855877,-0.09058869,-0.090293,-0.012624207,0.0458409,-0.033315007,-0.002562686,-0.018258074,0.017740222,-0.04823135,-0.007793853,-0.056018535,0.068823285,-0.061795607,-0.04470163,0.0005395654,-0.11057596,-0.051724777,0.018358395,-0.099438176,-0.056062188,0.082748786,0.14317141,0.025256382 +2.7.1.85,"Phosphorylates a number of beta-D-glucosides; GTP, CTP, ITP and UTP can also act as donors.",384,1.0,-0.07465012,-0.042731144,0.0018056368,-0.0390231,0.011970585,0.029829197,0.07796464,0.038022753,0.081114106,0.04800602,-0.013186245,0.05751078,-0.05412945,0.08644674,-0.038605396,-0.022358524,0.022023372,0.03866783,-0.040780257,-0.023486033,0.013814843,-0.005134633,0.015071617,-0.035737846,0.04684981,-0.05377749,0.04529723,-0.04102176,-0.020972885,-0.046809938,-0.10703274,-0.013859648,-0.04138523,0.060903326,-0.017503655,0.09780654,-0.04710554,-0.022223115,-0.042163197,0.0034748362,0.02784345,-0.019363914,0.03076883,0.05418883,-0.023443032,0.02591817,-0.047012817,0.08888767,0.013983222,-0.0076214075,0.073631644,-0.006513046,-0.01499213,0.055230465,-0.03620058,0.0798663,-0.07732944,-0.04091924,-0.007095404,-0.012091531,-0.03302012,0.007376141,0.03141711,0.02369935,0.06813361,0.009227172,0.02894531,0.009747884,-0.03978312,-0.044460613,0.010050425,0.0030806935,0.023367569,0.02064523,0.0890061,0.08644808,-0.028811378,0.01164571,0.014569924,-0.028843688,0.09439045,0.10336642,0.09691701,0.036331635,0.017609201,0.024381781,-0.027985815,0.04585415,-0.047846433,0.031670712,-0.041489206,-0.068062685,0.021478603,-0.002745155,-0.07375591,0.0072873444,-0.019455394,-0.04075078,-0.03148726,-0.04654639,-0.066157185,0.104876995,0.116460316,-0.013099149,-0.046704568,0.020603733,-0.048677895,0.006126142,0.029449657,-0.02296915,0.013985892,0.06659135,0.051253684,-0.019476581,0.031845868,0.013909243,-0.06591126,-0.07189024,-0.0798766,-0.06435412,-0.0032062994,-0.0754182,-0.06795794,0.026978336,-0.13940509,0.025834598,-0.054843202,-7.315971e-35,0.034273703,0.023794306,0.068524554,0.014142812,-0.023286179,-0.020322727,-0.004939443,-0.13496353,-0.014450812,-0.053677354,-0.11450073,-0.05422204,0.035199694,0.06498307,-0.06611681,0.08877262,-0.056839556,0.0191745,0.094446495,-0.053724837,0.0104493005,0.09266373,-0.030508287,-0.03203572,0.097754546,0.06405482,-0.116419494,0.0532356,0.033658054,-0.01206264,-0.0013727747,0.0015870809,-0.02514923,0.07250737,-0.043388568,0.022004051,-0.019501505,-0.06755937,0.021853391,-0.021072567,0.02632302,-0.02183847,-0.03498434,0.02932608,0.04113467,-0.03811978,0.0008901394,-0.10703915,-0.10527857,0.11472634,0.03244098,-0.025445675,-0.01363481,0.00037939433,-0.06414779,-0.02865114,-0.03418459,-0.033586565,-0.023964396,0.052885897,0.031739436,0.06280245,-0.00078771944,0.02675827,-0.06939026,0.021716554,-0.07280258,-0.123847194,-0.05426969,0.08277781,-0.04868938,-0.019022709,0.036923386,-0.006862486,0.010844006,-0.086372726,0.06564841,-0.0078058518,-0.0090100765,0.08715414,-0.026560472,-0.08595289,-0.032399494,0.059947126,-0.012304636,-0.016237933,0.046044968,-0.086912364,0.030491007,-0.062095914,-0.0071971114,0.032612715,-0.02573333,0.01738122,0.051379763,-2.6846061e-33,0.08162934,-0.10972323,0.05384225,-0.021771146,0.004672402,0.016400166,0.034914605,-0.12741591,0.04704756,0.025658717,0.012164413,-0.0024758356,-0.03543653,-0.04090005,0.0045808423,-0.07379187,-0.0020083273,0.025276257,-0.035795003,0.02006883,-0.026580745,0.06837113,0.0679369,-0.00524273,0.058210198,-0.021616187,-0.039418697,0.0014982536,0.063259065,0.014387494,0.057909124,0.080289446,-0.077899195,-0.069109365,0.00096766563,0.016632382,0.0074561797,0.018915862,0.013226513,-0.024384586,0.03623268,-0.008517553,0.072404794,0.018872213,0.03795424,0.09473963,0.024068514,0.020751351,-0.01582434,-0.04621025,0.03255499,0.011053836,0.00061441516,0.07271085,0.061516505,0.06973562,0.05366039,0.0070962836,0.03842691,-0.07798739,-0.10069881,-0.041141137,-0.0026595767,0.036490157,0.028285982,-0.032887604,0.069507964,-0.01923895,-0.04370174,0.08537097,0.009035893,0.0050273496,0.007089875,0.009644678,-0.010089135,-0.065636665,-0.1457869,0.0037148166,0.044190113,-0.02695833,-0.039401583,0.01951212,0.027915927,-0.015808256,0.052825082,-0.05598339,0.03255,0.061728023,0.016851185,0.037571818,-0.06252801,0.008275407,0.002199931,-0.0018262697,0.016125089,-3.1456217e-08,0.0797656,0.038707405,-0.0570109,-0.10182053,-0.03675162,-0.018929945,-0.0054568797,0.087455906,0.018815318,0.04760309,-0.0075786025,0.10474162,0.0028281128,-0.018577095,0.038191218,0.025677707,-0.02062754,-0.0416097,-0.0027212517,-0.072251216,-0.06755503,-0.022646682,-0.006021945,0.04101076,0.025089428,0.0063072005,0.09655142,0.017705629,-0.023381136,-0.024850307,0.05404807,-0.02539456,-0.09345088,-0.042758726,0.06300278,0.04401592,0.013939933,-0.04057567,0.040477663,0.034985695,-0.0700341,-0.028711276,-0.020707585,0.05611267,-0.045884285,0.045677606,0.0421526,-0.058694877,-0.014224223,-0.01986038,-0.0045640627,-0.08438181,-0.08090455,-0.09349218,-0.10345897,0.0153961,0.03318982,0.0066341404,0.0948608,-0.09909715,-0.02370696,0.034875568,0.06059678,-0.054474875 +2.7.1.86,"CTP, ITP, UTP and GTP can also act as phosphate donors (in decreasing order of activity). The enzyme is specific for NADH. Activated by acetate.",384,1.0,-0.12429377,-0.023548525,0.023498815,-0.09833839,0.006838629,0.039916813,0.015082691,0.03627526,-0.007442724,0.05803133,0.011673181,0.037853613,-0.06997465,0.09028866,-0.062628366,-0.005806826,0.010588533,-0.04269754,0.05772577,-0.026388913,0.05988793,0.021910453,-0.03867245,-0.06252188,0.08359014,0.05300957,0.007271573,-0.025248937,0.017638007,-0.047403738,-0.14501888,0.009384006,-0.043084554,-0.028568586,0.0103881555,0.14007424,-0.072018825,-0.012504889,-0.012065179,0.0240021,0.07034174,-0.043046482,-0.035555854,0.008013262,0.012182305,0.009052284,0.019540321,0.054966718,-0.02752123,-0.03941544,-0.0068911207,0.039538015,0.03177587,0.00472189,-0.03286861,-0.010881022,0.015312142,-0.006480818,-0.091326594,-0.041159064,-0.026223361,-0.040969227,-0.02656051,0.010730252,0.14024377,-0.014616366,0.08083405,-0.017843705,-0.01643423,-0.041550808,-0.047901977,0.0025964966,0.05086407,0.03983107,-0.0050369133,0.07649481,-0.044571716,-0.030002577,0.032430246,0.032069366,0.042354196,0.074712425,0.0047238627,0.038673654,0.10535105,0.005767515,-0.049884535,0.0662024,-0.0024063995,0.039670672,-0.036147695,-0.021760862,0.010104767,0.055246405,-0.10549519,-0.0050837053,-0.004254894,-0.04029377,-0.038465135,-0.07147161,-0.023549058,0.13418725,0.0360526,-0.05947875,-0.057141945,-0.009527325,-0.07441736,-0.0053493446,0.026601557,0.03324525,-0.01901028,0.054919787,0.03508994,-0.032199718,0.024321102,0.104279354,-0.10540647,-0.054031797,-0.060396224,-0.033853974,-0.041163426,-0.08326342,-0.04996423,0.090196066,-0.042901,0.020827003,-0.07353394,-2.4049231e-33,0.068923384,0.04124622,0.016083172,-0.02441671,-0.0035536478,0.008314375,-0.036475763,-0.02454792,-0.06361796,-0.06883755,-0.02307614,-0.041925352,0.05804124,-0.023578053,-0.07017626,0.010923562,-0.064568646,0.006742447,0.037717137,-0.05222293,0.043842018,0.10766017,-0.0533494,0.0444455,0.047094908,0.04243715,-0.1361345,0.020046739,-0.027312731,-0.0039714607,0.061358992,-0.04809459,-0.08803329,0.0536269,0.015936295,-0.032000355,-0.0215785,-0.07481338,0.014793095,0.05101808,-0.022489503,0.013859686,0.059958294,0.027736358,0.031248068,-0.11251136,-0.040739793,-0.016034955,-0.064781934,0.04376901,0.062399752,-0.052146085,0.05140905,-0.051898953,-0.06575094,-0.00420041,-0.015483471,-0.048061382,0.0037977041,0.07721612,0.07291108,-0.006690996,-0.021422543,0.06362024,-0.07551087,0.010125958,-0.050972942,-0.12000911,0.0626902,0.14126374,-0.01286155,-0.003133929,0.04759124,0.023217907,0.060301617,-0.05326171,0.032630067,0.04081319,0.018684981,0.053821918,0.0042417203,-0.12282651,-0.05220118,-0.022506287,-0.046594232,-0.011114961,0.06776542,-0.06125081,0.02611936,-0.0014323986,0.09268929,-0.0019152251,-0.034137074,-0.040761482,0.043455113,-3.7416754e-34,0.11610931,-0.052509446,0.0011018874,-0.06199425,-0.024428992,0.05216209,0.08314499,-0.09797388,0.052619245,-0.025036285,0.053461168,-0.01633814,0.057729807,-0.01668462,0.028609835,0.0029360196,0.022692244,0.036931723,-0.017729884,0.015960269,0.007942742,0.096891224,0.05454232,0.026394749,0.032821216,-0.026524795,-0.054373052,0.0024774014,0.08711227,0.038642373,-0.016621659,0.042240746,-0.12784342,-0.03684111,-0.028183581,0.015731592,-0.060285594,0.02002802,0.00094766245,0.020219153,0.069932766,0.0075462824,0.023545431,0.06274828,-0.037554618,0.044881392,-0.006713072,-0.004044439,-0.008910829,-0.046425607,0.08138228,0.085531205,-0.011929234,0.05884556,0.023412324,0.088917285,0.0021718566,-0.02421842,-0.01619696,-0.027259223,-0.020358747,-0.012089138,-0.026513675,-0.02015632,0.018286323,0.030735143,0.039566368,-0.006594186,0.047446914,0.009773702,0.014514012,0.026363488,0.06277529,-0.015347774,-0.027133916,-0.050162032,-0.14496264,0.049478628,0.012829899,-0.08266592,-0.024453275,0.05525832,0.009587646,-0.029348012,-0.007272496,-0.027104195,0.011392709,0.060195524,0.035642084,0.039070375,-0.043700244,0.017849648,-0.0060895514,0.046960384,0.015093799,-2.7717077e-08,0.04281174,-0.0061878893,0.025539028,-0.050729778,-0.040041666,-0.019055821,0.036857925,0.030365713,0.06550214,-0.015390347,-0.0070363176,0.115388475,0.029583849,0.005731269,0.0878924,-0.0032108556,-0.019716104,-0.03215177,-0.04389169,-0.08801418,-0.0849716,-0.022870818,-0.0545296,0.07435509,-0.027055748,0.08618396,0.009690779,0.00069589674,0.029377995,-0.061373778,0.010599288,-0.011161401,-0.0021613233,-0.04839839,-0.037158437,0.060992394,0.02332485,-0.049366213,-0.023293063,0.008941982,-0.05075682,-0.08533785,-0.06880066,0.040712293,-0.026147036,0.06798915,0.040509257,-0.054843377,-0.019316224,-0.03356458,0.020611897,-0.021724466,-0.057623237,-0.06642308,-0.036918066,0.024332821,0.036635555,-0.055151593,0.03139172,-0.07706101,-0.0058577647,0.045660146,0.123721056,-0.07134382 +2.7.1.87,"Also phosphorylates dihydrostreptomycin, 3'-deoxydihydrostreptomycin and their 6-phosphates.",384,0.99999994,-0.05959476,-0.054291453,-0.05248955,-0.06328423,0.0139405755,-0.0215467,0.029217472,0.058408584,0.08943667,0.025773823,0.0059751505,0.027685331,0.039228257,0.053523734,-0.019470984,-0.014636821,-0.107695684,0.07141829,0.02729912,-0.031741943,0.06963463,0.06578477,0.023508193,0.026454918,0.08042198,-0.020794146,0.03688962,0.109366946,-0.06089261,-0.036156226,0.03035587,0.009135964,-0.021816822,-0.0056591635,0.05307223,0.14848694,-0.04791932,-0.026000867,0.09649877,0.038041055,-0.010308757,0.024307363,0.011182628,0.03573193,-0.04777459,0.05321314,-0.09773661,0.06411863,0.070824616,0.017917592,-0.019847939,0.01063523,0.0014129032,0.10102778,0.09388878,0.017480193,-0.053878292,0.055934478,-0.031890634,0.023696495,0.021994118,-0.048669063,0.033971656,0.049532436,-0.02972179,-0.007688002,0.015900789,-0.05339379,-0.01799957,-0.0010461141,-0.0548219,0.014937897,0.07694857,0.031079952,0.013901377,0.02785958,-0.059820313,-0.041207988,-0.068761095,-0.063856035,0.06949023,0.020636886,0.023360388,0.088018574,0.025138145,-0.048559535,0.027970744,-0.026861599,-0.019371271,0.0072482023,0.005032838,-0.03895133,-0.06357889,-0.08388206,-0.04895284,-0.017288502,-0.04308138,0.01605056,-0.01405406,-0.041903257,-0.021682924,0.030589474,-0.017703267,-0.025723709,0.017035093,0.029187666,-0.020586185,0.074602626,-0.08393243,0.004365814,-0.016382052,-0.016881902,0.027522165,-0.037051015,-0.00966804,0.035460196,0.030360006,-0.04892071,-0.048138984,-0.08012773,0.014907779,-0.011449786,0.03297019,-0.015207446,-0.08068708,0.051884342,-0.07679148,2.849089e-33,-0.010619216,0.06482281,0.022921514,0.044520114,0.04640531,0.0010336444,-0.061843034,-0.029784938,-0.01691297,-0.08209682,-0.06523383,-0.0166805,0.06583619,-0.025518417,-0.004837085,-0.039592497,-0.020825308,0.08562292,0.011837617,-0.01283842,0.06103162,0.05976158,0.010021024,-0.017436277,0.038378265,0.04144432,-0.03421058,0.035321683,0.10570416,-0.04274573,-0.020670595,-0.059245344,-0.006674373,-0.008016247,0.036808178,-0.04401627,-0.08161188,-0.05418386,0.06475342,0.02550105,0.033774577,-0.07835705,-0.020362042,-0.028481305,0.013768429,-0.0030419421,-0.0073382542,0.013317541,0.016308205,0.046836197,0.071662486,-0.05270381,0.056812886,-0.0897729,-0.08650748,-0.04488694,-0.050195076,-0.020579075,-0.0046061156,0.06104487,-0.018224798,0.002099306,-0.01896648,-0.049474515,0.045037415,-0.022255698,-0.08386546,-0.06692237,-0.015565482,0.08633263,-0.0583174,-0.025136719,0.095337644,0.014888168,0.050716445,0.058640588,-0.037358303,-0.01434203,-0.024820337,0.054272626,0.0037369605,0.016382465,0.040800136,0.03292167,-0.018776277,0.018007305,-0.004804461,-0.09436421,0.012067558,0.015764836,-0.005988655,-0.07763377,-0.08862077,-0.027062612,0.0028600404,-4.29345e-33,0.09872219,-0.020791797,0.06156758,-0.025741905,-0.01172129,0.13334891,0.0036931557,0.0045717084,0.06375841,-0.056760125,0.03953346,-0.01837318,-0.09318951,-0.09360108,0.011857874,-0.041330196,0.004373941,0.08432766,0.014324311,0.053377777,0.061257932,0.07001949,-0.01176632,0.020894924,0.078456834,-0.0040656454,0.023077397,0.0045867423,0.044223126,0.06478485,0.00692876,-0.024877163,-0.046987634,-0.027520701,-0.040267903,0.04568358,-0.09892941,-0.05144642,-0.05724671,0.0019643037,0.004581355,-0.022801328,0.07258215,-0.017369123,0.013210423,0.015181928,-0.025928183,0.06649267,-0.026440797,0.004338727,0.0013216618,-0.035457175,-0.09282484,0.033377122,0.03366509,0.00075939717,-0.020180777,0.015491162,0.07155617,-0.061726004,-0.044753686,-0.06460479,0.023135109,0.036437117,-0.027096385,0.070245184,-0.027973557,-0.012574,0.041702047,-0.0010569905,0.023891335,0.034241147,-0.015569944,-0.008358051,-0.01260928,0.010139216,-0.08786015,-0.062830694,0.013810111,0.0725738,-0.018251896,0.006591657,-0.05349755,0.0062524145,0.027558258,0.016285706,0.041569304,0.026543258,-0.0589495,0.008887212,-0.01814156,-0.009152585,-0.027391268,0.02150484,0.006756229,-2.6745134e-08,0.090699516,-0.004632359,0.039217424,-0.06578559,0.010920808,-0.0726895,0.097363874,0.08854564,0.0010888166,0.011623203,0.05373775,0.030465895,0.035249352,-0.075709224,0.0014617343,0.018218918,-0.056803737,0.030981679,-0.023968818,-0.004296023,-0.039541923,-0.023345888,-0.10171828,0.061087687,0.10113127,-0.0028796417,0.028434185,-0.037671294,0.02159525,0.002613337,0.10149381,-0.06766433,-0.07463808,-0.124875166,0.035151266,-0.002337857,-0.1310836,0.009885758,-0.03275045,0.005534338,-0.006979775,-0.04340353,-0.03191729,0.08552178,-0.08340333,0.056637313,-0.086703934,0.015893767,-0.07701379,0.010909518,0.05888434,0.007613703,-0.028358696,-0.060281422,-0.1427635,-0.01777144,0.041365217,-0.08826829,-0.048771247,-0.075343184,-0.04016632,0.035774443,0.25373223,0.026242703 +2.7.1.88,3'-Deoxydihydrostreptomycin 6-phosphate can also act as acceptor.,384,1.0,-0.10359461,-0.0673831,-0.076999895,-0.08582419,-0.01266321,-0.08448468,0.0075379084,0.0490485,0.05549814,0.03444112,0.06951281,0.037337027,0.024075072,0.10859539,0.004957575,-0.006780376,-0.115494244,0.06328741,0.03071415,0.041592766,0.024749048,0.08934673,0.021713434,-0.013164089,0.04918501,0.00058256224,0.018658902,0.104583144,-0.014510475,-0.05772772,-0.014297764,0.014937044,-0.02499014,-0.0076724435,0.0379821,0.09584534,-0.11247056,-0.0035760857,0.059002865,0.030100856,-0.0038938702,-0.031956572,0.033331677,0.0047811414,-0.05619809,-0.009833101,-0.08509617,0.034468275,0.11059196,-0.030149499,-0.010190141,0.0045745927,-0.018975688,0.08882057,0.023092652,-0.00979032,-0.09511545,0.037875563,-0.044929814,-0.0067927414,0.025094679,-0.06831903,0.03177746,0.02797601,-0.025873125,-0.023538426,0.017103013,-0.10964629,-0.060400918,0.05544268,-0.035217,-0.028850209,0.058103606,0.004261105,0.039226457,0.017412432,-0.07806681,-0.048780702,-0.02323749,0.007843479,0.02218335,-0.0045493077,0.023585657,0.12345023,0.03142578,-0.045393158,-0.008499065,0.011250586,-0.0424172,0.051618766,0.018565264,-0.013480877,-0.015432937,-0.05948785,-0.01711378,-0.069855794,-0.03593927,-0.007768375,-0.05242786,0.006174971,-0.058138233,0.04474239,-0.09405158,-0.016148567,0.035715017,0.003309845,-0.037626192,0.021537587,-0.050998684,0.0006560508,-0.053453512,-0.04133081,0.0548829,-0.0032846068,-0.039930023,0.09385281,0.021159926,-0.09731626,-0.023918929,-0.08890754,-0.02853133,0.009606905,0.016188411,-0.03127434,-0.054337908,0.048941314,-0.018717587,2.2556045e-33,-0.034709245,0.06516227,0.027730841,0.017563293,-0.023971932,0.023241796,-0.045196686,-0.051622406,-0.09453381,-0.05782076,-0.0915916,-0.03346592,0.09632439,0.055660564,-0.014854541,-0.01251671,0.0042244336,0.10977948,-0.006934113,-0.0069322847,0.123199955,0.035785157,-0.040120643,-0.01033268,0.007712108,0.04699863,-0.019281123,0.048467055,0.10623958,-0.032191474,0.008264825,-0.0563274,-0.005363124,0.0162962,0.02258305,-0.0078119957,-0.05175145,-0.026078057,0.03317901,-0.02667006,0.003931301,-0.020322947,-0.056625083,0.0071096257,0.08839921,0.0047460147,0.031055564,-0.008112994,-0.036414765,0.04201,0.07069785,-0.036423728,0.056890476,-0.091330186,-0.03593335,-0.057178203,-0.0011538896,0.014677911,-0.015545304,0.02327251,-0.012669723,-0.011006785,-0.022827528,-0.009443467,0.016866788,-0.0024869675,-0.059767894,-0.06659101,-0.055159323,0.07129461,-0.056209262,-0.028692003,0.014736929,0.07660935,0.03927647,0.027796224,-0.03288847,-0.005484764,0.036647696,-0.0014286163,-0.016391087,-0.033684768,0.030904412,0.028168114,-0.0433467,-0.0023026501,-0.007948729,-0.115920894,0.042429086,0.019327618,0.042523433,-0.06789572,-0.12776372,0.008963725,0.06244155,-3.968843e-33,0.10925087,-0.0016377494,0.07266174,-0.026926473,0.0016975657,0.13543017,0.03599138,0.011774226,0.11585695,-0.06179963,0.08013679,0.03659184,-0.0068726353,-0.06424023,0.022121547,-0.024487864,-0.027680926,0.04245608,-0.021582985,0.043736707,0.06467753,0.06581094,-0.019676879,0.036756497,0.03818002,0.03799945,0.0399681,-0.008451201,0.015309912,0.059910335,-0.05403581,-0.021169536,-0.054445352,-0.008222953,-0.0030819713,0.080152385,-0.10696375,-0.023089617,-0.05806044,-0.03540533,0.0183661,-0.031354323,0.02570968,0.098905586,0.0036507505,-0.031770192,0.059402134,0.05323936,0.0073412415,-0.035387836,-0.044576567,-0.0015170393,-0.015864104,0.011366687,0.08204165,0.029096892,0.032987032,-0.07041493,0.025152935,-0.01961925,-0.006117594,-0.04881861,0.053226985,-0.006102045,-0.024703186,0.068480894,-0.0002917533,0.032111492,0.08193263,-0.058968443,0.05273283,0.027126966,0.021694172,-0.012405994,0.024339465,-0.023354733,-0.073228486,-0.033187408,0.013805092,0.043220975,-0.10694644,0.04440875,-0.011641283,0.027008744,0.0790017,-0.03748061,0.04981819,-0.008010213,-0.08738431,0.0082921805,0.010758272,0.032287456,0.006765528,0.027037648,0.031119794,-2.8906348e-08,0.05208933,-0.031023799,0.058701873,-0.073023684,-0.0029066158,-0.024033932,0.025855228,0.017960586,0.0064247167,-0.0041591185,0.026505282,0.08877128,0.0546877,-0.072751366,0.030393058,-0.015864698,-0.0720547,0.0041189436,-0.047854763,-0.04845718,-0.09485243,-0.04135305,-0.057382073,0.014488428,0.0691226,0.03833879,-0.0071593286,-0.008365741,-0.0059436914,0.004649755,0.08547923,-0.06411688,-0.095364675,-0.049884528,-0.010027654,0.0013310009,-0.05732005,-0.010816673,-0.012537068,0.0060841315,0.043534998,-0.043447997,-0.0563771,0.058604788,-0.10816297,0.11269651,-0.041181598,-0.016300289,-0.10281943,0.029146304,0.0653703,-0.04399098,0.0054762363,0.0012906111,-0.09901997,0.018808393,0.0080025215,-0.06135752,-0.0394964,-0.04040306,-0.038668018,-0.0078356825,0.23405147,0.0102505665 +2.7.1.90,"The enzyme catalyses a similar reaction to EC 2.7.1.11, 6-phosphofructokinase, but utilizes diphosphate instead of ATP as the the phosphate donor. It has been described in higher plants, primitive eukaryotes, bacteria, and archaea.",384,1.0,-0.092869624,0.022929424,-0.026796978,-0.018335842,0.06838659,0.018679952,-0.003788112,0.008592717,0.029111663,0.07674674,0.027154898,-0.09666174,-0.11600819,0.02368172,-0.016215773,-0.043022487,-0.06519742,0.01762832,0.031725094,-0.031363405,0.1060374,0.032931212,0.020460242,0.00662713,0.025517045,0.032345932,0.02634713,-0.039802216,-0.010306625,-0.07691879,-0.08143352,-0.06270719,0.02759259,-0.06996076,0.040209267,0.09424362,-0.011230422,-0.08549742,0.0152496705,0.017224003,0.03613791,-0.0033247685,0.021238752,-0.038649276,-0.09772281,-0.0041646864,0.058341127,0.016643062,0.041367263,-0.056477003,-0.0095363185,-0.072307095,-0.049133774,-0.04433267,0.019469723,0.007585209,-0.071560755,0.02771861,0.010563048,-0.018280856,0.015939767,0.007075044,0.026599586,0.040405005,0.032481268,-0.09641251,0.03059689,-0.06949457,0.011514839,-0.035281003,-0.03441689,-0.047418155,0.03633421,0.0035718987,0.038885057,0.08632255,-0.047816385,0.009410269,0.0061955675,-0.03242841,0.034835767,-0.03465132,-0.06064324,0.004604835,-0.0012381948,-0.020960703,0.0008247867,0.056327317,0.073332004,0.007171211,0.034000233,-0.014029443,0.05238511,-0.034135867,-0.0917051,0.05364711,0.0043337,0.09428636,0.036553465,-0.009627611,0.020178609,0.16386369,-0.019635126,-0.12104058,0.027065136,0.03525665,-0.05617678,0.065865785,0.051005792,0.0028886816,0.0016017479,-0.01710967,-0.0010777932,-0.012303949,-0.019225,0.06101205,-0.028790083,-0.11041806,-0.08567424,0.023327928,0.028394407,-0.09906928,0.0215798,0.10332632,-0.07228383,0.069470175,-0.17610745,5.116606e-34,0.05674509,0.040147126,0.029230487,-0.03919322,-0.0062552947,-0.014350289,-0.08005189,-2.4807548e-05,-0.06565023,-0.070170015,-0.088146254,-0.0090499725,0.1032076,-0.004213798,-0.03846412,-0.024540773,-0.06295189,0.023242353,0.09029879,0.029413974,0.032432202,-0.0031005307,-0.03691876,0.026430206,0.04045526,0.035031233,-0.022113364,-0.00011798909,0.056374177,-0.003095051,0.03444402,-0.14233439,-0.07812046,-0.035893217,0.033220872,-0.10022076,-0.011927598,-0.054061886,-0.012429859,-0.030931348,-0.044457585,-0.030888986,0.01630497,-0.01745435,0.046717446,-0.08401698,-0.061514437,0.061492417,0.052277334,0.05248739,0.0053862752,-0.08250403,0.14270118,-0.00887317,-0.042621706,0.009150135,0.027563844,-0.0022094382,0.0316008,0.095424525,0.015081545,0.10266442,-0.0422035,0.0016796617,-0.017673107,0.057614796,-0.04343093,-0.031958885,-0.0072059934,0.10033224,-0.047586404,-0.023746658,0.020255204,0.0116843665,0.02017264,-0.05769737,0.0014991501,-0.00073395664,-0.044639148,0.07673061,0.041981023,-0.04279415,0.0016505007,-0.0031897551,-0.05069761,0.0017168348,-0.036683373,-0.046847176,0.00052375987,0.073197685,0.06391937,-0.048887044,-0.031740203,0.0008543241,-0.015177878,-1.1099889e-33,0.094749816,-0.04156674,0.016778063,-0.0900645,-0.05702553,0.01334626,0.06619926,-0.026810901,0.0025305024,-0.05978238,0.007813929,-0.018054176,0.10183395,-0.033702835,0.021750879,-0.014905636,-0.01259208,0.05023808,0.041466776,0.02355948,0.013495993,0.07077563,0.014983027,0.036335584,0.06440657,-0.011333822,-0.016394185,0.057199676,0.007391052,0.0071312133,-0.04493912,-0.011526045,-0.045466848,0.0010008358,-0.073311195,0.016648224,-0.023698777,-0.022373533,0.047000214,0.015290935,-0.016396288,0.026891686,0.038730945,0.021215219,0.014027285,0.07509078,-0.01625298,0.08103286,-0.020120868,-0.016278675,-0.005375255,0.024425356,-0.025686763,0.040942416,0.04121302,0.015559454,-0.029065974,0.06413202,0.011648556,-0.015127033,0.007852265,-0.12701175,0.059081275,0.01830308,0.058356646,0.06463358,-0.04323824,0.03518391,-0.03979083,0.02178613,0.057416033,-0.0046006218,-0.017607756,0.029124456,0.025070695,0.026278216,-0.00010020034,-0.0022832023,0.0018242899,-0.058014095,0.01890944,0.046772663,-0.02253349,-0.07976224,0.04517284,0.005858364,0.03258855,0.08207233,-0.016341973,0.041963123,-0.053706273,-0.011821694,0.011833717,0.054739665,0.08824044,-3.4631565e-08,-0.008536183,-0.010950919,0.09775721,-0.039690036,0.08071052,0.029791957,0.02966077,0.015094138,0.027675264,-0.012289402,-0.024357257,0.05113789,0.09068622,0.0055728387,0.0733229,0.035175826,-0.026771722,0.04589554,-0.039918814,0.038483977,-0.00245155,-0.024556905,-0.11526647,0.08157425,0.009031486,-0.0377279,0.05510941,0.032684352,-0.072217934,-0.054749306,-0.010709806,-0.016532162,-0.03497868,-0.070678644,-0.026668381,0.037187926,-0.06451365,-0.015215198,-0.064849794,-0.0029160967,-0.04865026,-0.027830234,-0.08518536,0.022846257,-0.01260418,0.065370366,-0.0075291195,0.054207038,-0.034320854,0.028745156,0.06021078,-0.043827865,-0.006808938,-0.13537706,-0.091419,-0.067908525,0.004998607,-0.033966046,0.027733201,0.0012347901,0.10544328,0.044124514,0.18530554,-0.020252591 +2.7.1.91,"The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species.",384,1.0,-0.050429467,-0.026372291,-0.069571525,-0.031191334,0.047119394,0.043227427,-0.03660426,0.08474768,0.009135847,-0.043747216,0.037615743,-0.029782377,-0.077867076,0.04665378,-0.017299902,0.08146732,-0.061372872,-0.0019269019,0.006492425,-0.080893,0.07603966,-0.042121474,-0.050754968,0.06873823,-0.010580433,-0.019421317,0.045208674,-0.0630662,-0.015800878,0.011307091,-0.014320536,0.015647424,0.05335705,-0.029389128,0.00880271,0.12552716,-0.005516145,0.03510985,0.06863907,0.011370681,0.04617139,-0.01436465,-0.023475442,-0.03203949,-0.029148614,0.011459085,-0.05699598,0.099733986,-0.026064798,0.032547724,-0.008513114,-0.0019579364,-0.052776482,0.03573949,-0.009623562,0.01225698,-0.0661291,0.03533505,-0.0826833,0.085445344,0.0024076358,-0.0002663501,-0.021738252,0.02446497,-0.031258028,-0.067163356,0.031589486,-0.049148373,-0.0018691878,-0.030073453,0.0042888527,-0.029881667,-0.041827135,0.026386617,0.051457584,0.07766383,-0.013480093,-0.027772473,0.03751203,-0.12499171,0.059540145,0.0051446916,0.031611826,0.0845672,0.029552676,0.010767881,-0.03134232,0.053043015,0.029544635,0.059854332,0.025754238,-0.07322342,-0.055856973,0.006443545,-0.05453029,0.10781668,-0.046064664,0.021266235,-0.019117743,-0.032746375,0.008490698,0.013395235,0.01639928,-0.07684701,0.0021538276,0.045225095,-0.009426945,0.028335407,-0.03291357,0.043464113,0.082490586,0.044201035,0.08904069,0.015610538,0.0026577695,0.017405521,-0.05095816,-0.029762419,-0.0369614,-0.025355108,-0.011776121,0.040595427,-0.012628902,0.03880072,-0.092515424,0.039250795,-0.015642565,5.7516347e-33,0.028901597,0.016653111,0.03196093,-0.0030183457,-0.07951185,-0.020531973,-0.041156404,0.007800206,-0.04309852,0.05483018,-0.08812941,-0.07741716,-0.018899046,0.055320907,0.010615752,0.01115086,0.019036425,0.062217962,0.09983264,0.0490492,-0.037597187,-0.025412064,-0.07192842,-0.061454486,0.053344898,0.07616624,-0.13472092,0.03149835,-0.04825605,-0.027432393,0.02636065,-0.033637356,-0.06515922,0.006216556,0.017170504,-0.054432277,-0.06769051,-0.050077356,-0.03203893,0.036682516,0.006336975,0.010354873,0.006950579,-0.017452152,-0.01031183,0.013246181,-0.072779186,0.01474018,0.07078575,0.0473797,-0.0017219573,-0.013623767,0.11683952,0.0021327836,0.003988503,-0.011653268,0.021596003,-0.05358521,0.064091556,0.058831222,-0.005750869,0.09956403,-0.06705034,0.059457153,0.0618903,-0.025708705,-0.07427903,-0.0525868,-0.089454785,0.022128766,0.0112323705,-0.016215064,0.03398575,-0.024014102,-0.03356103,-0.059521228,0.037147604,-0.04916674,-0.0240675,0.060862128,0.020394009,-0.022086393,-0.023201028,-0.03204698,-0.074574865,0.018232757,-0.030388536,-0.04746802,0.022520091,-0.030805232,-0.043407075,-0.07859378,-0.054943774,0.02840775,0.020484451,-6.8112426e-33,0.026976012,-0.050915476,0.042172506,-0.12221465,-0.03643581,0.08790402,0.07090242,0.012526085,0.029945308,0.04465447,-0.04956337,0.009483222,-0.10135331,-0.025931045,-0.046918437,0.059654128,-0.019973848,0.015322254,0.043544386,-0.027182663,-0.031618834,0.11502139,-0.039213732,0.13823748,0.049256004,-0.017714325,-0.0016012064,0.057387806,0.007916726,0.054976404,0.0059965546,-0.07601563,-0.0030653668,0.01177432,0.02140424,0.0022953805,-0.02730902,0.020820508,0.043439828,0.011835407,-0.021582002,0.05376443,0.04442913,0.040714715,0.081958555,0.110234156,-0.10467199,0.029633148,-0.056155503,-0.05278459,-0.021865567,0.054525968,0.0043902737,0.021210581,0.0049764146,-0.009486032,-0.035169613,0.029126573,0.002615745,-0.1379294,-0.053363837,-0.13097593,-0.040734027,0.060496442,0.009190596,0.10713342,-0.037738245,0.03398279,-0.041562658,-0.028026218,-0.011848718,0.010544711,-0.053504672,0.022766475,-0.07712027,-0.04723719,-0.050462104,-0.09319388,0.020324811,0.029171245,0.077203386,-0.009341862,-0.0038918825,-0.047797218,0.021192553,-0.0047940915,-0.0026445673,0.047220163,0.03829685,0.033014853,0.03288442,0.017754413,-0.064549044,-0.017624646,0.038680863,-4.9966076e-08,0.0635259,-0.059094876,0.06640406,-0.09915463,-0.041811433,-0.04341928,0.07257981,-0.00913808,0.07594919,-0.038382366,-0.082757436,0.03799066,0.020774499,0.051745325,0.12960498,0.015615822,-0.034227617,0.015533708,-0.02853849,-0.012446909,-0.0023894187,0.012032049,-0.11228381,-0.00084451947,0.04061145,-0.076338366,0.062516265,0.022235347,0.018536657,0.06053984,0.034598764,-0.011743976,-0.032950595,0.02599985,0.09202653,0.013391107,-0.06781089,-0.025493085,-0.0570704,0.031527456,-0.06028919,-0.04674499,-0.0070080077,0.017513158,0.0035249218,-0.008429867,0.0062389444,0.031741653,0.06853966,0.047739692,0.015653148,-0.0036046125,-0.029937522,-0.08993089,-0.10731706,-0.0381262,-0.0362353,-0.0031078176,-0.028783737,-0.10393391,0.013433524,0.09430121,0.20802459,-0.0134475315 +2.7.1.94,Acts on both 1- and 2-acylglycerols.,384,1.0,-0.053062323,-0.12374954,-0.0314693,0.04156655,-0.022549966,-0.02507508,0.025845496,0.023286438,0.052424457,-0.07253766,0.058910362,-0.03540457,-0.06415013,0.021500237,0.05315018,0.063280515,-0.058728587,-0.08074424,0.017506888,-0.051503006,0.027562497,0.0009691473,0.0070058904,0.010880539,-0.021688782,-0.005158701,-0.034238365,0.011634101,-0.040265523,-0.061752938,0.072416335,-0.0984023,-0.06787545,-0.010155784,0.040291768,-0.023466567,-0.0061886064,0.043148555,-0.02774465,0.03668644,0.08069347,-0.10397824,-0.029942496,-0.00021864516,0.00048238222,-0.032092396,-0.054310273,0.04075417,0.010264234,0.08345984,-0.052837383,-0.050126743,-0.042323034,0.0017070702,0.028423015,0.055830795,-0.15678863,0.06719486,-0.01893481,0.0039602853,-0.0031936977,-0.017975053,-0.031616192,0.083649516,-0.07025707,-0.06149855,0.040921014,-0.08706674,0.0699134,0.031194786,-0.072896905,-0.09049887,0.02138857,-0.010650788,0.0689538,-0.056382105,-0.045127045,-0.07300384,0.049539585,-0.0057286527,-0.012614605,-0.03644456,0.053772617,0.06700489,0.019602673,-0.015405616,0.022231445,-0.058746934,-0.02430845,0.044204295,0.04768574,-0.03678742,0.063182645,0.036862865,-0.042785883,-0.017942911,0.0031949966,-0.001499331,-0.010269239,0.033499934,-0.039554983,0.00048823908,0.027868254,-0.031982444,-0.016774708,-0.0014678891,-0.06405865,-0.023397323,0.012912853,0.014956124,5.7059082e-05,-0.025493074,0.096205875,-0.0022146075,-0.06642592,0.08835476,-0.008711151,0.054662447,0.0014884304,-0.034121517,-0.045688253,-0.048236713,-0.0023146817,0.0026039344,-0.056951426,0.050434116,-0.04556517,-1.7985413e-33,0.06442323,-0.029627768,-0.027578954,0.0035594956,0.012577949,-0.009532867,-0.105225235,0.018845348,-0.046446383,0.03229015,0.07755595,-0.054479677,0.030699426,0.10710514,-0.014662993,-0.03424573,0.011311844,0.065641336,0.075806946,-0.07245015,-0.029610397,0.09287759,-0.02475198,-0.01763195,-0.02603593,0.042374484,-0.0043821735,0.055009868,0.0030774518,-0.0058678486,0.0001598816,0.002353791,-0.037519373,0.022459054,0.04032725,0.08335267,-0.014466724,-0.021614663,-0.0019088103,-0.019814203,-0.0071161366,0.037372183,-0.01715238,-0.06954502,0.06741759,-0.033397563,-0.12731387,0.13727129,0.0476933,0.00666414,0.037731424,-0.004928595,0.15923212,0.10885048,-0.00020447462,0.029776467,-0.05187042,0.022778522,0.03028152,-0.074679986,-0.0053778565,0.098467514,-0.029449694,-0.059142426,-0.05897568,0.025986336,-0.07255549,-0.013138225,-0.040468134,0.014115554,0.0011710863,0.047397204,0.08069142,-0.008459918,0.057844955,0.007359702,0.0045262855,0.019967252,-0.029183928,0.032451678,-0.011376597,-0.03645874,0.10582298,0.02092658,-0.072922714,-0.036129683,-0.06131619,-0.08744612,-0.0002464489,0.00019517954,-0.054228347,0.02812873,-0.050579887,0.040792827,0.037399188,-6.5129394e-34,-0.0009826754,-0.022609742,0.05754097,0.019948898,-0.015162985,0.034224503,0.026997177,-0.030922342,0.07811847,0.0017432107,0.079340704,0.041931856,-0.03587029,-0.08628107,0.045695357,0.03764491,0.004586356,0.023053419,-0.019338677,0.011884233,-0.01338553,0.064188875,-0.019536048,0.17929867,0.0063029756,0.027564056,0.028052628,-0.046225455,-0.021307012,0.06698399,0.05784353,-0.03427244,-0.039643977,-0.08649288,-0.05904616,-0.009701401,-0.07199856,0.021522906,-0.04923181,-0.0028732333,0.04803877,-0.028307447,0.066027455,0.040485986,0.046322532,0.030229911,0.029929547,-0.024958912,-0.081487164,-0.08242106,-0.09375397,0.010625595,-0.050777733,0.02977449,0.084748775,0.14178646,0.050259955,-0.06878121,-0.009724949,-0.06549084,-0.040917132,0.030051196,0.0072269305,-0.016559904,0.043602303,0.047085952,0.020852868,-0.033441085,0.059644587,0.021381957,0.08026349,0.093699895,-0.016844051,-0.039236356,-0.05622757,-0.020658959,-0.016882604,-0.11122976,-0.080712505,-0.025506532,0.0066012004,-0.010136019,0.051350284,-0.0652143,-0.060480226,0.0034699207,-0.024518158,0.013806757,-0.024317496,0.07889099,0.01996509,0.03810193,-0.02955426,-0.003567238,0.012153999,-2.007769e-08,0.045882914,0.0014834024,0.069694206,-0.060002282,-0.123662755,0.00599883,0.04623933,0.0655785,-0.02800696,-0.08061925,-0.01904028,0.111501284,0.062216695,0.018353278,0.083583005,-0.012078508,-0.024278047,0.030615298,-0.07894296,-0.07516011,-0.09548187,-0.038726162,0.04372996,0.044620402,-0.057872564,-0.077020705,0.035879105,0.03160369,0.00087577954,0.031724975,-0.0034739755,0.013230637,-0.021742623,0.014204461,0.021872634,-0.0002246187,-0.016423978,-0.011325562,-0.06274228,0.10420558,0.012497279,-0.023383062,-0.012256124,0.073681764,-0.006011786,-0.0464753,0.022994295,-0.019138308,-0.033714425,0.043557532,0.03515294,0.07329158,-0.014007687,0.0018812667,-0.07479443,-0.0110000735,-0.09647899,-0.005352272,-0.0028993303,-0.013363545,0.028705282,-0.01251878,0.1192994,-0.012021986 +2.7.1.95,"Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin.",384,1.0,-0.059208613,-0.0325847,-0.077941485,-0.02720176,0.04149604,0.034186304,-0.0710295,0.05251491,0.039749265,-0.00022153583,0.027607383,0.03927925,0.080054894,0.15302707,-0.06627843,0.061583772,-0.035174124,0.044470508,0.063513435,0.037128683,0.06796033,0.08090056,-0.035594955,-0.029657874,-0.00011246267,0.053133514,0.031721316,0.07872647,0.024834486,-0.023418186,-0.020137006,-0.04179478,0.05332895,0.024977535,0.057344615,0.046549458,-0.051977277,0.039478038,0.17303842,0.06237336,-0.03601272,0.014052415,-0.05291151,-0.0385043,-0.0012145134,-0.03592047,0.0027563083,0.052516874,0.05456797,0.052006494,-0.024769552,0.025967706,0.01690214,0.080140755,0.007985083,0.010380816,-0.052020367,-0.06705306,-0.05863632,-0.03233904,0.011411068,-0.083643705,0.008429864,0.007554556,-0.082061015,0.011552686,-0.009185046,0.0066097495,0.0053445767,-0.06711089,-0.022385707,-0.025539085,0.07304817,0.04945169,0.028823785,-0.07537156,-0.008698774,-0.038426522,-0.054827392,-0.07205428,0.007384964,-0.05015423,0.03393052,0.06603558,0.06062578,-0.053416062,0.024653092,0.028370598,0.0487546,0.04578639,0.022453465,-0.073742606,-0.026163748,-0.031132404,-0.033754002,-0.0356635,-0.015776543,-0.0056279674,0.02335559,-0.07035746,-0.025366323,-0.057784166,-0.06767648,-0.07233616,0.0076008583,0.029080326,0.048195295,-0.014517277,-0.0036129341,0.005142187,-0.036513306,-0.0009863946,-0.01659863,0.016409412,-0.024600316,0.042264126,0.13514219,-0.01774729,-0.16889411,0.0069203773,-0.009540196,-0.01637177,-0.03359837,0.04857776,-0.0273913,0.07194312,-0.07958773,1.8034772e-33,0.0004788513,0.046822656,-0.067032896,-0.028845685,0.056708038,0.054290008,-0.020868236,0.013318475,0.021009343,-0.08710781,-0.04340321,-0.03493365,0.020224148,0.019521812,-0.021230288,-0.0062939865,0.015054997,-0.04882341,0.021682056,-0.015450253,0.054685876,0.04446176,-0.08028158,-0.023253592,-0.003379006,0.07016072,-0.015485268,0.037332702,0.04074999,-0.04713572,-0.0013566309,-0.063434064,-0.046796426,-0.0039486047,0.099046335,0.06679319,-0.022482028,0.054083966,0.030160984,-0.003982105,-0.048570734,0.034192845,-0.11622058,-0.04517564,0.017209155,-0.046921607,-0.05889088,0.11446649,0.07619106,0.016190974,0.09211012,-0.112007,0.02968144,-0.045340292,-0.035019446,-0.0029407688,-0.058500092,-0.029208152,-0.01979586,0.047292173,0.08961801,-0.10849638,0.013296505,0.0042022713,0.022634378,-0.021696404,-0.024847733,-0.0059004,-0.016075129,0.041408833,-0.13771659,0.027696753,0.019460456,0.0316599,-0.04090795,-0.005802566,-0.075389355,0.029741943,0.09265948,0.037096944,-0.03179795,-0.075593986,0.0142573835,-0.011087491,-0.052144982,0.030567283,0.030849485,-0.059587788,-0.0058872243,-0.006347021,0.05400207,-0.13016424,-0.047345873,0.016904691,0.047093216,-5.194381e-33,0.02758514,-0.034042705,0.054618496,-0.02890231,-0.02392857,0.11003181,-0.021311829,0.0041516637,-0.00032973313,-0.01792776,0.004826464,-0.024696019,-0.06100233,-0.026899029,-0.030342015,0.04204738,0.05657373,0.041688908,-0.054633528,-0.043217853,-0.029328058,0.03649047,-0.0244948,0.02413147,0.021188844,0.08546529,-0.009557714,0.012604505,0.03933894,0.14394353,0.027100964,0.0059088427,-0.05983951,-0.08595155,0.023645328,0.093133084,-0.049641684,-0.0035235153,-0.05912824,-0.10251847,0.078474015,-0.03638358,0.017825289,0.13612057,-0.030870344,0.03149535,-0.054455344,-0.024662381,-0.067295074,-0.09257653,0.00039561198,0.0034464193,0.047708575,0.043370638,0.008257356,-0.027020723,0.005102559,-0.03904784,-0.012197534,-0.035729952,-0.021782257,0.0030875911,-0.09082942,-0.040356427,-0.02494946,-0.014983937,-0.017698161,-0.017073115,0.090862885,-0.031355184,0.00044377867,0.002347,-0.0031400397,-0.012152038,-0.11338809,0.04194073,-0.023751438,-0.09206284,0.03705855,0.025658837,-0.018599743,0.01076064,-0.032116253,0.0034734383,-0.06649642,0.011773199,0.03950307,0.06617452,-0.030277772,0.0138809625,0.012126098,0.05516475,0.0054221493,-0.0085380105,-0.040004145,-3.1009215e-08,0.05472519,-0.07814979,0.085093975,-0.04487978,-0.050668135,0.032561857,-0.025935655,0.019057347,0.013055299,-0.025819227,0.012845531,0.07497205,0.0403604,-0.026430828,0.03375504,-0.002319288,-0.0005566676,0.015454852,0.014369089,-0.036773726,-0.12915078,-0.014665404,-0.089508995,0.048385378,0.066274785,-0.02537303,0.011214683,-0.017000157,0.04592093,0.0027461653,0.04060023,-0.032178026,-0.035202242,-0.042944234,-0.041855324,0.024785146,0.007918664,-0.05109975,0.061976872,-0.03838492,0.10574682,0.007076411,-0.08068559,0.03698704,-0.014892331,0.02395821,-0.026950745,-0.059770495,-0.001962837,-0.033475317,0.0379793,-0.042462263,0.031722542,-0.012328794,-0.13371329,0.014389173,0.001008403,-0.082969494,0.0149048455,-0.03768246,-0.086098395,0.0102699185,0.13801931,0.049137317 +2.7.1.99,A mitochondrial enzyme associated with the pyruvate dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring). See comment on EC 2.7.1.37 protein kinase.,384,0.99999994,-0.08893307,0.06294686,-0.07731884,0.016907068,0.10211834,0.011541134,-0.059375457,-0.02050223,0.047352236,-0.016576368,0.07796421,-0.051626254,-0.048723735,-0.036166385,0.012118127,0.010366427,-0.09911583,0.006479134,0.012841404,-0.0768169,0.05721737,0.023346193,0.013923077,-0.008370077,0.03130691,-0.02760087,0.06884847,0.04887477,-0.03918799,-0.07427283,-0.047662392,-0.067033626,-0.005995606,0.017817173,0.0033640228,0.19753806,-0.04743922,-0.07936558,-0.005763193,-0.015309932,0.1124277,0.022721171,-0.020011928,-0.027807862,-0.049100075,0.026767578,0.033643402,0.027546415,-0.03104217,-0.019204395,-0.015836496,0.011355212,-0.034060914,0.03254719,0.019626476,0.0674097,-0.02877969,-0.0086982865,-0.06820476,0.0069600055,0.0144848395,0.00861162,-0.00014526541,0.011663927,-0.04382323,-0.046220984,0.1054718,-0.07612367,0.0130040385,-0.057953205,-0.06360114,-0.077200264,0.023372557,0.08380276,-0.0015052968,0.009782219,-0.074971415,-0.039305303,0.03496444,-0.04417255,0.013133924,-0.06181722,-0.013168938,-0.014764297,0.005857102,-0.0010579544,0.01822068,-0.05038085,-0.0364015,0.04368757,0.0215335,-0.09201798,-0.015863951,-0.01863339,-0.029017007,0.061278395,0.08959572,0.09251751,-0.02520006,-0.059994727,0.013269525,0.14366429,-0.026858367,-0.0114070885,-0.005010295,0.014913405,0.03358243,0.046776153,-0.03384869,0.011134685,0.0005619353,-0.010494018,0.05740249,0.013463354,0.008184328,0.14444771,-0.0048751063,-0.074849814,-0.017776778,0.0372061,0.0722268,0.0017602067,0.016159866,0.05803119,-0.06627244,0.066580735,-0.09565605,2.9713208e-33,-0.018294686,0.00045760616,0.035572525,0.013247158,-0.015641024,-0.060017783,-0.10291998,0.020520292,0.02066872,-0.07355343,-0.044287708,-0.00968108,0.06493741,0.0023208081,-0.048818193,-0.0530356,-0.027669827,0.02030452,0.10756658,-0.03730943,0.03637605,0.043519307,0.0067013134,0.005236109,0.015522443,0.0788211,-0.0074823145,-0.002757661,0.063220605,0.014288615,0.021742592,-0.09700341,-0.06374503,-0.0035033594,-0.06960143,-0.031104358,-0.056936987,-0.073681094,0.03155322,0.04883345,-0.050639194,-0.04238422,-0.008221298,-0.032332465,-0.029668976,-0.07025934,0.019921908,0.0507378,0.023860542,0.016680147,0.04165542,-0.09470417,0.0915455,-0.08597517,-0.042517107,0.006986225,-0.021091977,-0.0041537993,-0.004109176,0.074796416,0.07201689,0.0475986,-0.010358157,0.049998038,0.061493717,0.0011283633,-0.09087605,-0.11408905,-0.058641072,0.042717893,-0.06970933,-0.0031901498,0.13259415,-0.030009411,0.01465033,0.030705169,-0.081981964,0.0050898236,-0.08405815,0.038797475,-0.032745495,-0.016526282,0.047537412,0.018236771,0.009773111,-0.05385357,-0.0028886956,-0.010458875,-0.012364245,0.03399721,0.0050723506,0.011580786,-0.016468443,0.036134697,0.028648207,-4.669521e-33,0.07712952,-0.058397554,0.046585523,-0.07662259,-0.024080314,0.13853966,0.04908918,-0.03195646,0.005561697,0.0041988594,0.048488755,-0.030345758,0.007521218,-0.0743884,0.081616774,-0.019213099,-0.043088354,0.05155039,-0.025649697,0.031397697,0.024677226,0.07013466,-6.368825e-05,0.065554276,0.041887548,-0.012475979,-0.026138594,0.031975687,-0.023440747,-0.010305926,-0.03697172,0.006433111,-0.017728433,-0.005620995,-0.018525675,0.026687019,-0.039014705,-0.0076667755,-0.003909399,0.043537155,0.061073497,0.06665185,-0.00014477338,-0.015410476,0.059156936,0.02079833,-0.089477114,0.0012594637,-0.0070345527,-0.03807767,0.025128823,0.04930588,-0.06542469,-0.013549243,0.0690163,0.07947262,-0.014431474,0.06052129,0.07139888,-0.038298525,-0.10045985,-0.09077278,0.035337016,0.034848824,0.042147096,0.002229938,-0.026586661,-0.02128405,-0.0028571282,0.06777364,0.07997601,0.059743237,-0.035495177,0.018574443,-0.013935306,-0.012143573,-0.031165985,-0.008135171,-0.0058947527,-0.106988095,0.012093272,-0.011483573,-0.0076655718,-0.08453422,-0.012197321,-0.028115747,0.00714608,0.06250275,0.011523389,-0.021938892,-0.007983021,-0.08595601,-0.11753094,0.036483597,0.010652315,-3.4190318e-08,0.022150822,0.0070932712,0.074863665,0.00770767,0.054400813,0.011672242,0.07554293,0.048075344,0.017224394,-0.004801039,0.0327176,0.044426605,0.11339937,-0.024979768,0.029592017,0.020994037,-0.0196035,0.073848225,0.015590213,-0.013597322,0.022198722,-0.060017172,-0.120028086,0.08028293,0.06070122,-0.05030988,0.050276358,0.02383517,0.0054379404,-0.106632344,0.01489204,-0.02054025,0.026862154,-0.039421614,-0.01076563,0.025092185,-0.027174521,-0.019605635,-0.043155506,0.077209,-0.045968127,-0.056234293,-0.05446154,0.018100485,0.015982913,0.0677258,0.045588244,-0.015839156,-0.029966218,0.014605932,0.03927531,0.0041681747,-0.017749246,-0.08321961,-0.116674155,-0.0071527925,-0.04457352,-0.07008347,-0.011958678,-0.077684216,0.14441553,0.050999973,0.10455936,-0.006621009 +2.7.1.100,"CTP also acts, but more slowly.",384,1.0,0.00037114855,-0.11027158,0.068965055,-0.018518915,0.011357357,-0.02212286,-0.031423688,0.024151279,0.048323322,0.011186899,0.06578915,0.03470051,-0.059942424,0.09635562,-0.0047933683,-0.005051129,0.023590859,-0.05912352,0.07987775,0.02017804,-0.082856275,-0.010876227,-0.0202224,-0.04521851,-0.027399339,0.043011732,-0.024695257,-0.028754564,0.031105997,-0.09358673,-0.043393154,0.050626393,-0.080461964,-0.023627708,-0.004004061,0.11720029,-0.090963244,0.0049423394,-0.009375294,-0.023877038,0.10054612,-0.013750132,-0.014190105,0.015896771,0.066676386,0.008516024,-0.015116728,0.032878324,-0.028393554,-0.032545216,-0.030860504,0.021621633,0.0006592747,0.03333738,-0.092944436,-0.021458214,-0.017997218,0.0001240633,0.024860421,-0.03681426,-0.08233885,0.03141207,-0.013348041,0.06322632,0.09489979,0.0821987,0.044647444,-0.04113778,0.022745334,0.04689728,-0.02892159,0.07598977,-0.013565537,0.029956244,-0.02055673,-0.032864735,5.912149e-05,-0.06016202,0.027280701,0.020801267,0.0016324203,0.081687525,-0.046054587,-0.024481302,0.06923481,-0.012341755,-0.017334241,-0.0380387,-0.061590724,0.020987136,0.0064762393,0.03926373,-0.0043846485,0.06859234,0.0007249361,-0.021628013,-0.013985886,-0.012702282,-0.08887362,-0.022639824,-0.05016633,0.06685157,0.006695807,0.025638722,-0.0027428293,-0.063887864,0.016952764,-0.061532587,-0.07324209,0.049368627,-0.0033154117,0.012967539,0.03608224,-0.0028895896,0.06536306,0.09980335,-0.0654577,0.014623825,0.015879352,-0.011994338,0.0023388756,-0.07644545,-0.104721405,-0.0019521485,-0.024333587,0.031693034,0.031038867,-1.8623945e-33,-0.009369872,-0.038435593,-0.027641872,-0.01753007,0.044486918,-0.009282276,-0.034152374,0.0040228697,-0.032546885,-0.046470426,-0.0490998,-0.09934884,0.017141966,0.023066545,-0.05547328,-0.0753997,-0.04119616,0.10225419,-0.04561732,-0.05322585,-0.0020165655,0.103465095,-0.040266123,0.015723078,0.007354872,0.03609984,-0.11494529,0.041368205,-0.010671601,-0.0002486195,-0.018037124,0.06952704,-0.08437003,0.08578242,0.0141137615,0.09434718,0.0014797301,-0.038004465,0.059576575,-0.0037674757,-0.064939894,0.04122824,-0.053886235,0.022200376,-0.016946869,-0.0738901,-0.07930944,-0.033198066,-0.08710928,0.046049986,0.109874286,0.02517628,0.003218608,-0.05025913,-0.018331714,-0.008730397,0.061502095,0.008198668,-0.029344695,0.10476701,0.09386647,0.00886307,-0.008358691,0.031559505,-0.035995446,0.02535705,-0.026133863,-0.08049718,0.06424264,0.010570081,-0.0033607353,0.036386713,0.10950492,-0.06569258,0.106143765,-0.062980704,0.01657968,-0.031933982,-0.02535124,0.022988364,-0.031276714,-0.11838045,0.008635803,-0.023084845,0.045596555,-0.038087588,0.051786896,0.006570944,0.00046991286,0.0039805174,0.050516546,0.050171196,-0.024163678,0.06201777,0.035144094,9.62358e-34,0.024125002,-0.046700202,0.003701154,0.076192625,-0.028453317,0.028486554,-0.0042125736,-0.008287696,0.05896105,-0.010657796,0.08537104,-0.0146489525,-0.04386705,0.055110198,0.03271604,0.034124825,0.13521005,0.040632598,-0.023085944,0.02317234,0.01679587,0.05942075,-0.0049993475,0.072542995,0.012410687,0.046063863,-0.020955596,-0.0042782016,0.023283934,-0.03700043,-0.055295534,0.07208715,-0.115380675,-0.039021153,-0.0239709,0.08433237,-0.046816394,0.027384138,-0.026124736,-0.06446433,0.11833735,-0.0045431037,0.053202763,0.04272177,-0.049766455,0.0187226,0.115098834,-0.040057387,-0.081502415,0.09722462,0.023534663,0.075929984,-0.024468964,0.05665104,-0.0048333355,0.0787927,-0.0016649237,-0.111377925,-0.08026865,-0.04258295,0.005218313,0.040513575,-0.070128836,-0.03433285,0.13271284,0.010859592,-0.012129835,0.0076911384,0.09722688,-0.005064932,0.007789733,0.061886434,-0.041832533,-0.03068507,-0.03773857,-0.057219,-0.044072464,-0.015990235,0.034256652,-0.10076569,-0.034228835,0.00975642,0.09073109,-0.048902363,-0.13908626,0.057452474,-0.083199665,-0.05010994,0.022050638,0.07532803,0.025419846,0.0118649965,0.022111442,-0.006998443,-0.03498094,-1.7435063e-08,-0.0022439607,0.032985013,0.007156015,0.00539891,0.053111155,0.032441154,0.024360547,0.08242193,0.01733054,-0.027264297,0.020093232,0.06049008,0.09778425,-0.054392044,0.0790639,0.0055963225,-0.044128377,-0.044582717,-0.045332376,-0.044385992,-0.062300075,0.007088515,0.015169768,0.012189307,-0.07953541,0.0654837,0.007891005,0.07654523,0.024892772,-0.07199611,-0.010996466,-0.02034892,-0.07674949,-0.013979721,-0.011824061,0.040732108,0.09994643,-0.063805856,-0.01047997,0.026065992,-0.06068258,-0.0065512205,-0.03331839,0.0069592325,-0.072155304,-0.0034017188,0.03359129,-0.109541796,0.07457723,-0.07963316,0.047878824,0.027993377,-0.009818705,-0.0032261338,0.00931279,0.016147591,0.019838506,-0.04143112,-0.030542027,0.0126986755,-0.042683247,-0.024946144,0.055793457,0.015597778 +2.7.1.101,The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.,384,0.99999994,-0.032943442,-0.1329578,-0.053786956,0.032644488,0.03040739,0.024264202,-0.09040472,0.058201153,0.05244987,0.015338898,-0.034721464,0.01492088,-0.0008658517,-0.045761034,-0.065789044,0.03421366,-0.037744243,0.022441218,-0.0574488,0.021135686,0.07795259,-0.005078612,-0.05579832,-0.07546865,0.06577746,-0.0038651868,0.018786313,-0.036113888,-0.0941751,-0.08792712,0.024962688,0.013046689,0.12638284,-0.01813204,0.026700988,0.091862366,0.010978576,-0.014028554,0.0981239,-0.059813138,-0.016809644,0.0110217035,0.04433936,-0.008471326,-0.0027871544,0.027282069,-0.04925241,0.01963002,0.056733824,-0.026531607,-0.035161972,-0.05415558,-0.021481933,0.010090478,0.05512032,0.093268774,0.020819899,-0.1272221,0.032046154,0.061272725,0.03989109,0.0006265892,0.010584979,-0.008220371,0.027419887,-0.055009153,0.01865135,-0.07302387,0.0084787,0.02893198,-0.11077914,-0.044585567,-0.0065656654,0.014043637,0.020663925,0.03233014,-0.044112206,-0.022217369,0.1068615,-0.040152706,0.0473511,0.04575054,0.034451425,0.03365128,-0.021685632,-0.032610767,0.083452374,-0.03436384,0.081239425,0.016884753,0.0456775,-0.0034634492,0.010330143,-0.061183173,-0.045304347,0.027623609,0.02570398,-0.052581027,0.012544696,-0.030993683,-0.009895978,-0.012184213,0.042255957,-0.043253604,-0.071889125,-0.033600673,-0.04422989,0.1547907,0.0073169935,0.005948598,0.013290714,0.014298267,0.0025535226,-0.06954378,-0.06132574,-0.008983282,0.05261184,-0.05572563,-0.058208805,-0.02638968,-0.03878572,0.0039336584,0.044703566,0.014422271,0.055601005,0.006849488,-0.041216552,2.0441742e-33,0.06307392,-0.05491584,-0.012031621,-0.043451805,0.03770253,-0.022847652,-0.06325495,-0.004796843,0.056099143,0.0141833555,-0.036495358,-0.04835089,-0.017474407,-0.07826707,-0.008807851,0.1112686,-0.01267115,-0.0473965,0.008491741,-0.036021806,0.031486236,0.037083805,0.005565475,0.00090651686,0.04457787,0.061905395,0.053005356,-0.020920513,0.043795273,0.015089789,0.011006668,-0.038232785,-0.1082555,0.0146169765,0.06329445,0.035610016,-0.045673486,0.0034608024,-0.044412233,0.055833038,0.0365713,0.042863984,-0.022427484,0.018076213,0.06030862,-0.036907673,-0.0066008097,0.11413579,0.05878986,0.11035576,0.059387796,-0.07195742,0.07091378,0.028872887,-0.002760843,0.028009124,-0.0841528,0.05985937,0.028350178,0.030096447,0.0097407475,0.05781632,-0.008329294,0.061283167,-0.014891038,0.019803273,-0.08046466,0.036696006,0.031289324,0.07771738,-0.011966488,-0.033771574,0.014291002,0.050391465,-0.0364064,-0.058380228,-0.05782807,-0.04137324,0.04354282,-0.020323213,0.0054330216,-0.016379971,-0.018607989,-0.005566615,-0.039780352,0.0019482628,-0.08507669,-0.054339465,-0.030587975,-5.6807785e-05,0.05713607,-0.05011071,-0.09146753,0.1222638,0.0020860308,-3.102029e-33,0.09170609,-0.11098199,0.09865365,0.006018431,-0.018486999,0.026413506,-0.023825709,0.020345535,-0.030034596,-0.034317743,0.020482974,0.053667676,-0.0074492204,-0.026951218,-0.007878385,-0.022119803,0.022751518,0.019240292,-0.08268538,0.013136903,-0.061106715,0.06330275,0.02594664,-0.015647776,0.025794355,0.020903045,-0.0068506333,0.107439734,0.038150437,0.033690512,0.074505545,0.063510545,0.0009049917,-0.03777195,-0.090802535,-0.005731946,-0.034188356,0.00031893668,-0.0003300434,0.017144725,-0.016922047,0.05739813,-0.0037735743,-0.001452067,0.06608304,0.022002121,-0.06305259,0.002136885,0.08949049,-0.07448656,0.0395628,-0.09664103,-0.01130105,0.016888347,-0.03851135,0.055022836,0.07068279,0.017653184,-0.03710141,0.0027067622,-0.02124018,-0.034532897,0.09487303,0.0052894526,0.10360216,0.08527489,0.06041176,0.14654565,-0.031847373,-0.03267794,0.06499522,0.034384247,-0.025415517,0.02725747,0.05152923,0.03355993,-0.07335176,0.015890686,-0.006248144,0.019238831,0.033067085,0.012997345,-0.025027283,0.0035724046,-0.075250104,-0.038676128,0.023890994,0.0858653,-0.033854757,0.039377004,-0.11859954,-0.009604957,-0.030997746,0.037118297,0.07741228,-2.6598578e-08,0.03561645,0.03141382,-0.0095326295,-0.07883785,0.044593852,0.04351936,-0.0900223,0.051895175,0.054052383,-0.05551103,-0.10821369,0.11641894,-0.07658234,0.045183208,0.013824294,-0.018464388,-0.039934713,-0.048262913,-0.018405637,0.021118471,-0.09100456,-0.050440367,-0.056074757,-0.0062548425,-0.017412737,-0.06813269,0.053065076,0.037435453,-0.028775236,-0.02497194,-0.021616753,0.025495306,-0.02272321,-0.0222585,-0.109945215,0.0322157,-0.01340728,-0.13769133,-0.013035699,0.0695762,0.023618035,0.009369437,-0.07002713,-0.02022177,-0.0779453,-0.018896228,-0.025750145,0.027976662,-0.06199796,0.021659194,-0.003048209,-0.02131074,-0.1214829,-0.035664853,-0.071170144,-0.01077357,0.038570855,-0.0710477,0.00946739,-0.0081461845,0.0044410923,-0.0803922,0.08017737,-0.019410932 +2.7.1.102,"Also acts, more slowly, on D-hamamelitol.",384,1.0,0.06711874,-0.06798947,0.07957675,0.011558911,-0.018786287,-0.029397856,0.015783545,0.038189992,0.07232381,0.0028883277,-0.016037527,0.049667522,-0.06273269,0.065225,0.02385117,-0.01043375,0.0146981785,0.06040025,-0.057271756,0.010116522,0.030015267,-0.039970532,0.07693611,-0.053441614,-0.03838463,0.04356134,-0.05086438,0.04839504,0.03758243,-0.121116094,-0.031544726,0.06670513,-0.018370297,-0.03153462,-0.042821668,0.12411239,0.018467367,0.10398496,-0.011290589,-0.02291573,0.04455366,-0.017262217,0.04648104,-0.0013774098,-0.06262603,0.0068184016,-0.05856581,0.0040591746,0.01631047,0.008490007,-0.05010575,-0.120012134,0.051658776,0.029798657,-0.014556453,0.021219214,-0.056272067,0.010942072,0.054722466,-0.06917728,-0.058100875,0.02897031,-0.014948869,0.031472534,0.036083862,-0.035220988,0.055219878,-0.04272286,-0.02396436,0.020214481,0.03880231,0.033701003,-0.053948067,-0.026724178,-0.08070313,-0.07607135,-0.028668078,-0.1105007,0.045239247,-0.0563363,0.010071206,0.04259446,0.022358386,0.008962869,0.016054038,0.04255894,-0.008140008,-0.10243424,-0.08734367,0.040493745,0.0018708019,-0.03739863,-0.075100526,0.03717198,-0.0114342645,-0.019038882,0.04711089,0.07125103,-0.03942228,0.030567277,0.0033531429,-0.0076995483,-0.0367745,-0.04395615,0.011410626,-0.011166638,0.023711832,-0.009045885,-0.044409104,0.033065416,-0.07572019,-0.022434354,0.011469136,0.055962685,-0.027567191,0.03766908,-0.028035294,0.047247984,-0.072753645,-0.038171258,0.0733732,-0.010121694,0.0137630785,0.04288899,-0.019153802,0.059811022,0.017562006,-2.2124499e-33,0.03250551,-0.07084826,-0.041556805,-0.008170846,0.030562865,-0.06937559,-0.07635617,0.083952576,0.00083385967,6.652202e-05,-0.14219482,-0.10751096,0.004460448,0.03404245,-0.014340853,-0.056067735,0.046887733,-0.028391413,-0.061043277,-0.047344033,0.045876328,0.09008626,-0.018040711,0.010888158,0.0038712255,-0.012323955,0.019765524,0.054157685,0.04018343,0.011410635,0.02531589,-0.02442036,-0.039170474,0.032308612,0.035768803,0.13582854,-0.055304278,0.018444696,-0.045812782,-0.03812391,-0.027063409,-0.020980932,-0.13762684,-0.07618395,0.00534716,-0.0037284403,0.00583392,0.049379084,-0.025929913,0.08286528,0.12347012,0.076476075,0.019287668,-0.008030691,0.008895672,0.073004246,0.09181017,-0.01125302,-0.027906094,0.14624535,-0.026923828,0.025173796,0.038367394,-0.010308055,0.0011733455,-0.024046589,-0.045063164,-0.032147713,-0.09474286,-0.00068420754,-0.025142921,-0.00022504102,0.029265769,0.024767067,0.0046673454,-0.095332436,0.0045392583,-0.07148787,-0.013767706,-0.021814065,-0.03851824,-0.018653948,-0.02263936,-0.0043859193,-0.032116324,0.010360381,0.06663259,-0.10708454,-0.07568131,-0.023830323,0.015209173,-0.052369617,-0.068066455,-0.0112314485,-0.008373196,-3.8858693e-34,-0.049614422,-0.061766054,0.013388223,0.07397098,-0.03310486,0.14463063,-0.03655444,0.071450375,0.00090463366,-0.059924666,0.037161823,-0.004058333,-0.099262446,0.054544818,0.03997286,0.006568047,0.016123805,0.07185015,0.022164134,0.026093483,0.0058791293,0.10253017,-0.037290677,0.078350686,-0.0071350606,0.039058473,0.028571228,0.04301587,-0.04214044,0.05834997,0.025993928,0.038551148,-0.08512781,-0.079145074,0.0006835514,0.14420526,-0.040129192,-0.028187223,-0.09770953,-0.04650291,-0.025157321,-0.020744469,0.072607554,0.1135652,0.022785736,0.071481794,-0.0010052908,0.03822775,-0.07075294,0.08728814,0.004705726,-0.0031223511,0.002318734,0.0404459,0.057591006,0.030354658,-0.020089392,-0.0821554,-0.07142719,-0.032461755,-0.02126847,-0.01559175,-0.051348705,-0.02066311,0.10777233,-0.009814024,-0.045074478,0.02184946,0.10080205,-0.0090417955,0.04796486,-0.0054612462,-0.09152259,0.020141989,-0.076877594,-0.08177059,0.023110995,-0.07506867,-0.036368176,-0.049498092,-0.04481961,0.0026640235,0.036962062,-0.016507449,-0.10230784,0.035751946,-0.01647841,-0.029509654,-0.05930102,0.10312727,0.027587345,0.025496533,0.023715397,0.05424053,0.009493065,-2.0587983e-08,0.041162614,-0.025066108,0.03159427,-0.03559683,0.023854263,0.051635012,0.008422376,0.07388253,-0.044737943,0.024281597,0.012928238,0.12450927,0.09094586,0.005234508,0.06585846,0.012546607,-0.025134662,0.012839803,-0.08185547,0.04148663,-0.059464034,-0.0038406341,0.0067214696,-0.04234204,-0.027233634,-0.048255,0.064594105,0.039052624,0.008318155,-0.0004389957,0.044446625,0.024272354,-0.0082633495,-0.035464294,-0.04104169,0.047899373,-0.011589884,0.011853952,0.010964118,0.012481493,-0.014018848,0.00093760167,0.024143994,0.049676314,-0.07670508,-0.049834654,-0.029068649,-0.076894104,0.057372343,-0.036878336,0.045707684,0.049056105,0.021379305,-0.014300734,-0.06427647,0.087758765,-0.057757128,-0.007564105,0.053237375,-0.03239369,0.026520817,-0.060328886,0.030992987,0.01590177 +2.7.1.103,Acts also on capreomycins. A serine residue in the peptide antibiotics acts as phosphate-acceptor.,384,1.0,-0.04830331,-0.0419969,-0.042357218,-0.079386294,0.062145885,-0.021179782,0.041995134,0.06722303,0.12814355,0.007334547,0.053767927,0.079017736,0.027985219,0.15243484,-0.04766286,-0.049571123,-0.07800015,0.061649717,0.06152727,0.031575937,0.10652996,0.09397268,0.03590449,-0.00016799496,-0.0131093655,0.02855155,-0.0218206,0.018791938,-0.0032916646,-0.0229654,0.0039146054,0.0076786135,-0.014913031,-0.038546667,0.019700138,0.066481784,-0.040721666,0.0083174445,0.09991527,0.0003591133,0.023545537,-0.038780637,-0.013141994,0.0013764896,0.0074593765,-0.008808339,-0.0056565907,-0.009490692,0.03993854,0.007415006,-0.062258944,-0.041273292,-0.035080455,0.03407686,-0.008877957,0.030507047,-0.07394557,-0.0535769,0.006661898,-0.030239305,-0.06906154,-0.06318171,0.05595215,0.012230746,-0.0054339636,-0.037121262,0.023033006,-0.08093184,-0.04057977,-0.032165013,-0.04306279,-0.07582882,0.08579719,0.0226218,0.020584187,-0.00566413,-0.0945621,0.026518164,-0.10112104,0.06317907,-0.0053940173,-0.06002463,-0.019552443,0.11494384,0.039163645,-0.018440854,0.039316557,0.0010575025,0.027845053,0.0516383,0.03376441,-0.004582112,0.021851253,-0.019284965,-0.049020182,-0.100767724,-0.031903964,0.058827724,0.0048274267,0.0031438274,-0.07681951,0.01583574,-0.0882362,-0.04439264,0.021642366,0.00024408287,0.017982507,0.023767825,-0.048934508,-0.06027006,-0.02655774,-0.05796349,0.0029525356,-0.011745224,-0.025042482,0.06138081,0.08744863,-0.041987468,-0.059156496,-0.08641618,-0.037429478,-0.023584109,0.017070524,0.020545948,-0.025384055,0.08521756,-0.0714739,-2.6479125e-33,-0.0014231927,0.0360272,0.060414415,-0.047610875,0.002858311,-0.05323959,-0.050578754,-0.06653051,0.0051656296,-0.060358852,-0.032614447,-0.026830079,0.043707244,0.0073785908,-0.011792205,-0.051662236,0.024385031,0.10608114,0.035042338,-0.05419775,0.09554208,0.053562537,0.038496807,0.029225685,-0.0028285545,0.0011954799,-0.10428777,0.007507233,0.13710506,-0.030391816,0.03636318,-0.0051472783,-0.03350814,0.008043736,0.04726377,0.015111545,-0.01754392,-0.051139865,0.055425454,0.024333943,-0.0409361,-0.008457016,-0.021267995,0.013905372,0.02777387,-0.03720319,-0.035085935,0.08231403,0.03184131,0.03819585,0.054902434,-0.10340322,0.0141544305,-0.044609353,-0.047779847,0.03230635,-0.0050882995,-0.0020974316,-0.023317246,0.051218882,0.002790396,-0.062454347,-0.024152678,-0.038599424,0.06967351,0.025291221,-0.039821237,0.0054389057,-0.010122552,0.08761279,-0.027256431,0.049868204,0.045624074,0.11455303,0.05738722,0.023136726,-0.063374534,0.018067123,0.05686999,0.037410915,0.013249211,-0.032314673,-0.062169284,0.0221552,-0.018937392,0.0057456554,0.04017034,-0.10158523,0.033270624,0.013194156,0.035764225,-0.06919724,-0.08969944,-0.026958939,-0.0253072,-1.5362545e-34,0.117196344,-0.056020446,0.024522614,0.027517088,-0.062154654,0.05129667,0.003392851,-0.02666786,0.072545886,-0.042515885,-0.0034023782,-0.034463063,-0.037671715,-0.054373376,-0.08861745,-0.057291698,0.009059028,0.016095256,-0.040500093,-0.0144827925,-0.028508978,0.017845115,0.08786234,0.03511854,0.054947715,0.022994068,-0.022363784,0.060174756,0.0037517766,0.045525834,-0.0053400146,0.008844859,-0.052660834,-0.11306436,-0.011137067,0.100519836,-0.07307927,-0.01098848,0.031542372,-0.067333035,0.019080602,-0.06782503,0.0723649,0.075472586,0.033982895,-0.011898867,0.024853675,0.06800542,-0.037503213,-0.12477017,0.00043323042,0.027815647,0.062314384,-0.03270978,0.039876107,0.060236342,0.03708007,-0.045974854,0.020323755,-0.043123018,0.055366054,-0.011880938,-0.027796004,0.003828802,0.0075114314,-0.026309198,-0.0044283904,-0.038967546,0.09675194,-0.02149539,0.023432726,-0.040503543,0.05312777,0.006885838,0.032823592,0.008533128,-0.0948472,-0.03614554,0.0140250325,-0.007297746,-0.10409493,0.035483655,-0.04438256,-0.028509019,-0.008201641,0.012236951,0.027793616,0.006062814,-0.026888907,-0.025790706,-0.03193101,0.023405138,0.021917647,0.075463034,-0.017440714,-2.2068683e-08,0.10926782,0.0242226,0.079168424,0.009672425,-0.025374563,0.00454926,-0.008263295,-0.043064475,-0.022106972,-0.022628544,-0.005123018,0.07718395,0.030155666,-0.05471565,0.021373365,0.0553956,-0.021741508,0.014740594,-0.043349624,-0.062200427,-0.08981298,-0.005564042,-0.047298774,0.039674107,0.044345018,0.021600697,0.015651742,0.07006484,-0.08325198,-0.022011261,0.08383,-0.08179887,-0.026640143,-0.042425327,0.03821659,0.014341427,-0.09415624,-0.058868043,0.0936768,0.020551492,0.052311286,-0.017688246,-0.08949397,0.04815028,-0.06737885,0.14008257,-0.051073253,0.01342888,-0.09156885,-0.017173037,0.07557807,-0.004897333,-0.083722234,0.035524018,-0.08995947,0.03959588,0.071626194,-0.06732833,0.029039986,-0.093148634,-0.046596523,-0.016176295,0.141378,-0.004734434 +2.7.1.105,"Not identical with EC 2.7.1.11 6-phosphofructokinase. The enzyme co-purifies with EC 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase.",384,1.0,-0.029960476,-0.049133334,-0.082737595,-0.052177068,0.07379452,-0.0045898184,-0.0023231364,0.04091489,0.0085870465,0.003813162,0.02977121,-0.10134476,-0.08680821,0.042860188,-0.014638086,-0.09450656,-0.038943987,-0.069237284,0.022431364,-0.025241012,0.097742625,0.008489282,0.011974611,0.045694467,0.039905075,0.009245781,0.044262305,-0.022251561,-0.026855396,-0.0899464,-0.02754268,-0.09138976,0.015025462,-0.039650038,0.05371022,0.038233336,0.03035387,-0.08656158,-0.017843258,0.035594076,-0.0019064862,0.029062591,0.0130029945,-0.034561403,-0.060795058,-0.022353329,-0.029900027,0.02158675,0.00018104457,-0.025287824,-0.012479595,-0.106584325,-0.04209351,0.023232218,0.028651154,0.044239864,-0.12516949,0.018485172,0.0002517718,0.068704404,-0.042706273,-0.0105868885,0.089690946,0.062188298,0.0599008,-0.058170028,0.02046617,-0.13393575,-0.041974798,-0.013770834,-0.05979438,-0.041170128,0.04107368,-4.0338695e-05,0.05363748,0.103315525,-0.046699286,0.0007410166,-0.0245236,-0.041752968,-0.005850967,-0.060868055,-0.038552724,0.021505365,-0.010059646,-0.06391072,0.011656061,0.0058637336,0.010326408,0.034169663,0.058828685,-0.042195845,0.09103024,-0.007516691,-0.04597029,0.030712493,-0.030108918,0.1542522,0.057052724,-0.031044144,-0.045736086,0.12703611,-0.016342625,-0.07805863,0.00238814,0.018115832,-0.027320722,0.06156086,0.046459146,-0.022789525,0.022435661,-0.031333838,0.021579454,-0.0073069683,-0.014811276,0.07479565,-0.0017982089,-0.11114906,0.010496363,0.022014154,0.08536617,-0.059612375,0.074347824,0.058963567,-0.040711652,0.062339697,-0.10912387,1.32547255e-33,0.008271534,0.025108397,0.05465383,-0.06277822,0.0069746887,0.0071846195,-0.09089172,0.04360211,-0.03131592,-0.052776057,-0.06505995,0.06454822,0.066862985,-0.036186215,-0.026557242,-0.031659793,-0.019473327,0.014611548,0.02644421,0.008505944,0.06713329,0.011437682,-0.013344585,0.044781603,0.039423116,0.048998352,-0.05015389,0.06869032,0.039416835,0.022376675,0.03492465,-0.098860875,-0.05161691,-0.01414094,0.0113393115,-0.044965684,-0.0292379,-0.029473038,-0.043401703,-0.011434072,0.0370252,-0.033030875,-0.005044799,-0.0331583,0.025977965,-0.10801236,-0.10599199,0.08630663,0.1024455,0.03530397,-0.03399815,-0.034277987,0.08124881,0.013367647,0.0026278046,-0.016347578,0.0060799094,-0.019106215,0.072610594,0.0467133,-0.013046403,0.13707277,-0.038840905,-0.0037551103,-0.063399516,0.04258287,-0.04228295,-0.013521404,-0.038959697,0.069315076,-0.030827587,-0.0004219823,-0.0025848278,-0.0017693185,0.06260377,-0.094302416,-0.030885926,-0.0027998583,-0.0833407,0.05432282,0.008813324,-0.012642139,0.0021775204,-0.010444483,-0.11384458,-0.010158757,-0.009643772,-0.021021357,-0.0050628516,0.08852366,0.023735017,-0.0019967295,0.018394478,0.07044222,-0.010108975,-2.0920604e-33,0.054626614,-0.049511567,0.049883295,-0.08592912,-0.015363292,0.04924993,0.10320259,-0.01351386,0.039780483,-0.08211539,0.072114855,0.00454829,0.016781755,-0.059608914,0.07273501,0.02697921,-0.021009643,0.042821616,0.047624964,0.008292409,-0.0017645065,0.05479131,-0.016513431,0.04931766,0.09588257,0.019167973,-0.00030672428,0.04522511,0.046102777,-0.0034844377,-0.08763562,-0.009845696,-0.023141293,-0.0033656675,-0.08725416,-0.056068555,-0.04936088,-0.006313534,0.0075122,-0.021422334,-0.025666025,0.031674813,0.0043062796,0.02973602,0.02971757,0.103163846,0.00584317,0.033196796,-0.0064580264,0.030774178,-0.022132417,-0.0016336798,-0.05775845,0.04525233,0.021261511,0.048548877,-0.016772661,0.090956435,-0.006914296,-0.037229132,0.0014503633,-0.09798192,0.05510498,0.035677746,0.09654582,-0.0108079035,-0.04077569,0.029067732,0.01289234,0.04909272,2.0474949e-05,-0.032127336,-0.031266358,0.0027582466,-0.0032476285,-0.027396178,-0.058067,0.03273146,0.02002586,-0.04168993,0.025577674,0.06323098,-0.016376512,-0.027515166,0.041181087,0.015512801,0.022578854,0.041568913,-0.029545637,0.036358535,-0.07250317,0.00012649038,-0.05772997,0.0062494352,0.07560493,-3.3329048e-08,0.053785574,-0.08174701,0.012978751,-0.023460636,0.12977247,-0.00214765,-0.022637747,0.0025076042,-0.026541084,0.033041414,-0.016699836,0.06616514,0.10146848,-0.009881868,0.015266965,-0.010656082,-0.06444114,0.020687453,0.019081978,0.047829427,-0.041190892,-0.022573398,-0.08790885,0.03759649,-0.030142779,0.003541063,0.034559052,0.04925673,-0.10133793,0.00041439396,0.0052600773,0.013115517,0.020332254,-0.06640851,-0.03662811,-0.008693867,-0.058843438,0.02845826,-0.13398947,0.039766673,-0.0069852816,-0.018945392,-0.021391954,0.006780975,0.007111202,-0.009100855,0.052633367,0.040845547,-0.033965576,0.007672475,0.02107641,-0.014718908,-0.030037072,-0.07543944,-0.061865356,-0.09413753,0.00083592755,-0.09794634,-0.021099683,0.0070222146,0.14387934,0.0053157727,0.20219955,0.011591176 +2.7.1.106,"D-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate.",384,1.0,-0.098770656,-0.07105945,-0.055585854,-0.034546535,-0.024810307,-0.027982991,0.110705525,0.0033892272,0.031281374,0.10197782,-0.03676771,0.07013127,-0.124907404,0.01835527,0.008982221,-0.02419925,-0.0787106,0.017457964,-0.017838603,0.088706896,0.08358814,0.01790212,0.042319965,-0.026790394,0.07160736,-0.0078534605,0.09680983,0.0066701877,0.024145432,-0.037949502,-0.05814456,-0.0077926833,0.045940045,0.037672993,-0.0072940253,0.14588386,-0.028568445,0.0006909706,-0.050580934,-0.0320075,0.058241,-0.046567746,0.09042602,-0.016611923,-0.049841348,-0.031229781,-0.09777669,0.08353297,0.044165716,-0.06756456,-0.009955679,-0.050817445,-0.06400127,0.033847466,0.029178273,0.034336247,-0.07082819,0.051872276,-0.030654306,-0.031710107,-0.03407277,-0.026252339,0.037963,0.030869992,0.09531286,-0.075024344,0.021228233,-0.04183826,-0.061762936,-0.032310303,-0.053365637,-3.7500296e-05,0.033163145,-0.04683046,-0.00086644274,0.030298905,-0.0903121,-0.025455583,0.071293354,-0.010344697,0.040276997,0.0068364013,0.070257135,0.08250227,-0.019282212,-0.010812213,0.019723292,0.049293626,-0.009805663,-0.00083664345,-0.011234963,7.720533e-05,0.018359162,-0.0379836,-0.055122107,-0.005728659,0.007016981,-0.0085121915,0.05980297,0.00047131546,0.023966663,0.1165799,-0.05349782,0.013718776,-0.030299539,0.0029445519,-0.042544533,0.03162869,-0.05144307,-8.416618e-05,-0.0490977,-0.0033184092,0.07679811,0.09290788,-0.10460381,0.020942632,-0.03918611,-0.07135214,0.014627944,-0.028951015,-0.046497304,-0.030254764,0.0035158056,0.019416887,-0.048468687,0.09335464,-0.003548291,-2.300083e-33,0.02278964,-0.009295541,0.027108723,-0.037622016,-0.074548274,0.051364385,-0.062198885,-0.034258578,-0.07755271,-0.022705514,-0.05799292,-0.049403816,0.06636024,0.06826327,0.0023485823,-0.0028017538,0.006418302,0.07150842,0.09340502,-0.029061742,0.044974744,0.10321245,-0.056443278,-0.02728778,-0.005695831,0.05461466,-0.087813154,0.09323516,0.019002223,-0.028185824,0.05871999,-0.0066083907,-0.030219069,0.05225564,-0.008405124,-0.017314997,-0.05070265,0.033017214,-0.010211784,-0.04894474,0.032650117,-0.02830938,-0.050395593,0.025016394,0.014684946,-0.007562964,0.046606004,-0.061406564,0.035233796,0.08499142,-0.0127575,-0.021879794,0.0064991764,-0.044855952,-0.014756528,-0.023236524,0.0048463647,-0.016757712,-0.007838003,0.037715163,-0.0022659418,0.042207178,-0.007750807,0.045130286,-0.03257426,-0.06254288,-0.052383766,-0.060785554,-0.039962474,0.061163712,-0.010072149,-0.05325558,0.022203451,-0.00054823305,-0.020456402,-0.024943074,0.020824466,-0.012185803,-0.07146797,-0.03071265,0.033728477,-0.045613144,-0.026061067,-0.023721779,-0.12846397,0.051427037,-0.025342384,-0.12200526,-0.025093028,-0.018004688,0.019894488,-0.055615455,-0.13606013,0.021104595,0.067961596,-7.535708e-34,0.053985972,-0.0044044275,0.06553519,-0.045026377,-0.013884181,0.05179904,0.123965144,-0.10725398,0.103911765,-0.025013996,0.031898722,0.074202485,0.005180541,-0.037795123,-0.019291548,0.0463257,-0.052296434,0.07270208,0.016678758,0.008061931,-0.027023625,0.105526455,-0.047984455,0.07206343,0.045730233,0.032291967,0.06684728,4.9529084e-05,0.021064818,0.033071518,0.015795425,-0.011966831,0.023676949,0.008117262,-0.03386038,-0.034905065,-0.049354002,-0.03581805,-0.07767949,0.010178314,0.007010562,0.06914767,0.06564783,0.026341142,0.095782384,-0.03772767,0.091615856,0.051809832,-0.045482386,0.0060227797,-0.0076204017,0.0027116933,0.020332377,-0.0018013672,0.08178646,0.06525159,0.022541912,-0.0025856283,-0.07802512,-0.004301389,0.02815455,-0.05574849,0.07684902,-0.044359032,0.01189866,0.008954338,0.023370009,0.032527328,0.067579396,0.045215808,0.06317355,0.027632844,0.012104738,-0.013810257,0.028458085,-0.04304092,-0.069237605,0.0014079731,0.022596644,-0.020745417,-0.10164866,0.124468185,-0.02462409,-0.0006020286,0.011650809,-0.07737657,0.06876107,0.00081094506,-0.032301813,0.06302704,-0.030405927,0.006571417,0.01915697,0.015750065,0.060064644,-2.6315034e-08,0.100449644,-0.11264401,0.010391639,-0.03782784,0.029157193,-0.033901922,0.0038784624,-0.0026390369,0.015732758,-0.017581686,-0.044900168,0.099468715,0.045498233,-0.035612144,0.06482404,-0.018102132,-0.09830039,0.0055464497,-0.10187247,0.01507229,-0.037114605,-0.039840203,-0.08025811,-0.0054733343,0.011493367,-0.03725693,-0.012940393,-0.00020444611,-0.023797102,0.036279835,0.03709586,-0.0062358542,0.011965659,-0.06694675,0.004143601,0.058976695,0.01682949,-0.05031318,-0.053142887,0.035749618,0.038361404,-0.113235414,0.00817535,0.019189661,-0.10981486,0.098696105,-0.071938254,0.012985317,-0.048693437,0.05087523,-0.012776985,-0.0014100436,-0.07657658,-0.07016911,-0.03058046,0.0019493834,-0.06461118,0.007372984,0.022357313,-0.0020737401,0.057763927,0.029777743,0.10577191,-0.07934886 +2.7.1.107,"Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Activity is stimulated by certain phospholipids [4,7]. In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. cf. EC 2.7.1.174, diacylglycerol kinase (CTP).",384,0.99999994,-0.07094433,-0.0409263,-0.10435828,-0.016973807,-0.004526203,0.05635853,0.020054236,-0.0057330015,0.079188116,0.0055577024,0.06595756,-0.049331535,-0.070259176,-0.012100268,0.008592596,0.0052322564,-0.021553362,0.05618068,-0.040017612,-0.05847014,0.010923027,0.026905524,-0.03287108,0.0319393,-0.019533288,-0.018229656,0.02544551,-0.019102586,-0.03259435,-0.050906207,-0.022321895,-0.046836194,0.0706678,-0.048816167,-0.012856207,0.09033923,-0.040763576,-0.021783823,0.011447116,0.014340699,0.075222224,-0.072882324,-0.019638829,-0.010547727,-0.011369854,0.053425767,-0.068255015,0.059117597,0.059770934,-0.049224846,-0.0095776,-0.03778548,-0.04686637,-0.063502274,-0.057645373,0.025553634,-0.09117024,0.09037549,-0.0021777116,0.002641072,0.006172846,-0.016687237,0.08234373,0.057836663,-0.017537044,-0.0651494,-0.03432445,-0.031684972,0.05963386,0.009093235,-0.028055746,-0.07676486,0.072917126,-0.040726572,-0.06638529,0.056047317,-0.01761363,0.04971372,0.023378937,-0.09292633,0.10291354,-0.062341087,0.0055183433,0.11132133,-0.009927065,-0.0007319384,-0.06405616,0.0033698822,-0.015840536,0.055141624,0.06721963,-0.042793036,0.039811943,0.07679354,-0.065524556,0.041615706,0.035998628,-0.04180577,-0.016779928,-0.039547987,-0.01804164,0.0513844,0.00050630665,-0.042875323,0.03875464,0.031310868,-0.096615605,-0.051549096,0.003914517,0.020840742,-0.016908161,0.043586913,0.041790668,-0.033122472,0.041122366,0.054200254,-0.00964603,-0.05027903,0.011006242,-0.0040972373,-0.0010970555,-0.12070563,-0.03736593,0.002951525,-0.045274787,0.03225343,0.008318799,2.448726e-33,0.036312673,0.08253824,-0.014576984,0.03186557,-0.028541593,-0.077114135,-0.0028312383,-0.050124824,-0.08273271,-0.06979993,-0.036599863,-0.064870015,0.011971376,0.063499935,-0.053451348,0.03708644,-0.00982469,0.0049097687,0.12695783,-0.06850061,-0.059854142,-0.01933852,-0.021145897,-0.029188588,0.035735115,0.0856733,-0.033006493,-0.023491392,0.04539405,-0.015408353,0.04588699,-0.07590858,0.014390136,0.09016404,0.07309382,0.0072970777,-0.05076936,-0.0654436,0.05105632,0.10421385,-0.025911,-0.039896287,0.033437017,-0.000386499,0.024048457,0.024939451,-0.13580732,0.09555309,0.052764766,-0.02405602,0.032877207,-0.013182403,0.055953287,0.063201524,0.0096536605,-0.042315647,-0.007665695,0.021155152,-0.022001155,0.0017790153,0.0042090183,0.049419302,-0.07113785,0.0012964428,0.07611824,0.047013193,-0.13475658,-0.078942366,-0.021778185,0.009393141,0.04452215,-0.045208856,0.07880856,0.002878898,0.041786864,0.01960027,0.055263944,0.088973396,-0.050687958,0.11392502,0.040220533,0.009770643,-0.02110877,9.688961e-06,-0.059671648,-0.0056751794,-0.011231848,-0.041323785,0.007635813,0.026101923,-0.015040373,0.020289809,-0.019636944,0.070130065,0.015838418,-3.4995047e-33,0.043971412,0.031032246,0.020606963,-0.029143348,-0.03869059,0.03941242,-0.029769825,-0.08064263,0.061021633,0.067901626,0.0138309,-0.018704519,0.053270314,-0.018998282,-0.041687325,0.03779579,0.013359377,0.07196953,-0.035133295,-0.08849766,-0.02951534,0.03622904,-0.04571823,0.13108467,0.028470188,-0.013013612,-0.0695809,-0.010544971,-0.051122144,0.0768406,0.04458064,-0.05772731,-0.06274739,0.0009477768,0.008423029,-0.015647136,-0.06360308,0.021837948,-0.004546735,-0.014910449,-0.03218491,0.015111803,0.11486397,-0.024435015,0.043744646,0.0427227,0.038420737,0.012826066,-0.08003491,-0.022004796,-0.009328217,0.07473751,-0.02568703,0.09694154,0.033391066,0.11931096,0.039707653,0.043643624,0.05637361,-0.095817275,-0.050037153,-0.1046123,0.007424262,-0.018974258,0.02427709,0.10275241,-0.03076085,0.0103813745,0.06247049,0.030096594,0.014044361,0.06699786,-0.011030383,0.014050414,-0.0833362,0.018985983,-0.06249252,-0.060024057,-0.024644293,-0.025657276,0.023637801,0.027845947,0.013127759,-0.084012344,-0.06905051,0.0026384438,-0.002992243,0.07882307,0.002801494,-0.027702704,0.01774353,-0.05292738,-0.11819693,0.010256651,0.070704035,-4.019318e-08,0.020739838,-0.052770067,-0.0080848755,-0.11706966,0.0039406996,0.01099207,0.080186695,0.0738657,0.035069756,-0.05771703,-0.06752535,0.059942223,0.03603921,-0.041555453,0.08866227,0.035068527,0.054712616,0.041709933,0.01431033,-0.075537674,0.05683696,-0.024210373,-0.074712634,0.023325501,-0.002080631,-0.048336346,0.049024656,0.008878714,-0.010796972,0.027691016,0.058416944,-0.021397037,-0.022707382,0.0031681207,0.06424934,0.034143116,-0.044759966,-0.062150557,-0.03646907,0.07594954,-0.046928626,0.033448867,-0.035193432,0.05088449,-0.056264065,-0.011307545,0.06656335,-0.017420396,-0.057338428,-0.0007343082,-0.03752028,-0.00583038,0.014396375,-0.11536972,-0.098965526,-0.050720636,-0.0039017322,-0.0051931283,-0.046720672,-0.0013125231,-0.060121663,0.05123564,0.12160582,-0.020349417 +2.7.1.109,EC 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. See comment on EC 2.7.1.37 protein kinase.,384,0.99999994,-0.055429157,0.028877182,-0.043409858,-0.025451336,0.00985443,0.06897923,0.010338497,-0.022291046,0.0019540247,-0.048387818,0.03745696,-0.009817705,-0.023895694,0.021729372,-0.008159098,0.038347393,-0.032490104,-0.04582951,-0.054498494,-0.05887834,-0.04062322,0.012929578,-0.013680255,-0.016972888,0.065831155,0.007441665,0.0228504,0.005183108,-0.02883157,-0.1220313,-0.019751694,-0.055239815,0.023141306,0.0072145597,0.013826937,0.07114499,-0.05054312,-0.06670625,-0.051654033,0.05568461,0.05310921,-0.043389667,-0.07511269,-0.0401847,-0.074090034,-0.039101545,-0.024916708,0.061533134,0.0053357407,-0.011532464,0.023942998,-0.020914204,0.014247211,0.039182223,-0.00089773635,0.009741768,0.0023519422,-0.007343116,-0.05502931,-0.0697189,-0.024746547,-0.106238805,0.00872396,-0.00558216,0.026432803,-0.059084732,0.10107714,-0.12352582,0.02465942,-0.03541472,-0.058901146,-0.0841595,0.055901688,0.04521662,0.041183043,-0.006058758,-0.0554683,-0.064788535,0.047491487,0.015491796,-0.017616516,-0.03523024,-0.019023146,0.049490977,0.0673633,0.017127242,-0.02097698,-0.002507575,-0.0488737,0.042253602,0.042057488,-0.079956874,0.015976967,0.03919245,-0.08414895,0.04914615,0.074683495,0.045801416,-0.036181994,-0.012008217,0.02573726,0.07685652,-0.055644933,-0.008068187,-0.062310297,0.04007755,-0.00784017,0.07849337,-0.053351752,-0.023409488,-0.012265534,-0.083379544,0.0184646,0.016307715,-0.03303175,0.14609897,0.018455205,-0.043415073,-0.019694643,-0.054724865,-0.013589405,0.01901133,0.04301392,0.05652997,-0.019154716,-0.0034809934,-0.13231699,1.3167237e-33,0.03403911,0.04845677,-0.0034719715,-0.008248831,-0.03352529,0.012130834,-0.08414951,0.07841504,0.04381575,-0.16189842,0.016646469,0.023718234,0.08196786,0.0063497713,-0.048091255,-0.014886814,0.039902348,-0.020327682,-0.007651473,-0.06443248,0.05614068,0.0220631,-0.019358976,0.02562302,-0.018439798,0.0058540376,-0.10895074,0.056484032,0.029171763,0.04644035,0.003048748,-0.016170744,-0.015282668,0.10393604,-0.00090002397,-0.019336121,-0.043488555,-0.008512959,0.007040911,0.055717383,-0.00725864,0.0045404597,-0.0426346,-0.06707458,0.029335197,-0.100880206,-0.015547271,0.05952368,0.030150935,0.045415197,0.039443303,-0.058985863,0.09743351,-0.07777553,0.026249247,0.028889455,-0.029372387,-0.047991756,-0.05330625,0.036975674,0.027594993,0.09538106,-0.038137857,0.055012163,-0.033717893,0.0137757305,-0.10946598,-0.046419285,-0.07026779,-0.0070060096,0.0026678634,0.074536555,0.09381264,0.03136245,-0.022304475,-0.023187088,-0.038512763,0.015478431,-0.060171504,0.098530225,0.00783676,-0.027178407,-0.07056342,-0.01149708,-0.060352504,0.0057746167,0.14168938,-0.10182501,0.02524972,0.024865827,0.025353318,-0.061655566,-0.032526605,-0.02793643,0.0477956,-4.1294106e-33,0.10883882,-0.004467005,0.04854147,-0.053777408,0.026025945,0.058381185,0.12843688,0.026374228,0.06714652,-0.033540927,0.052365273,0.052110948,-0.0053824005,-0.02913225,0.055432707,-0.02138369,-0.017377343,0.03373968,-0.069652185,0.02150578,-0.05356672,0.024864834,-0.0006701353,0.045777693,0.019252168,-0.057350636,-0.058950808,0.030944582,0.04176774,0.0112806205,-0.047291126,0.03485387,-0.014116967,-0.030307496,0.049595963,0.019495897,-0.12629095,0.020276535,-0.02412567,0.009169069,0.0035057962,0.0048031867,-0.06947538,0.023029866,0.11452476,0.094157845,-0.03218926,0.085650116,-0.023212621,-0.0727445,0.0326507,0.031600595,-0.00012712638,0.048539408,0.048231836,0.047135957,0.006805585,0.063916445,0.039344702,0.005709199,-0.037777517,-0.0310459,0.026324062,0.042314034,0.021675725,-0.049705774,-0.025084851,0.055996794,0.047282416,0.07686329,0.07638673,0.03380011,0.037183642,0.019187577,-0.0350942,-0.042275444,-0.09468801,-0.027570497,-0.06791011,-0.116551384,-0.008732741,0.015651088,-0.021402933,-0.08184269,0.05944085,0.0045006406,-0.021482693,-0.0071918415,-0.040496532,0.0039037752,-0.035647925,-0.019140841,-0.08677422,0.12229372,0.014676653,-3.8746816e-08,0.04583502,-0.014116816,0.049029835,-0.048475705,0.09787427,0.0481222,0.09156649,-0.06632283,0.080991,0.030098505,-0.028650543,0.08349765,0.104150794,-0.034374442,-0.02962579,-0.013786091,-0.0561586,0.032025743,0.010605587,-0.055497587,-0.015203005,-0.038926892,-0.06719099,0.036632925,0.0016448952,0.00013034587,0.03352907,0.021028742,-0.0023804607,-0.104655996,0.08036188,-0.013293263,0.11305648,0.0075090206,-0.017635195,0.014014876,0.027442837,0.018525625,-0.053962436,0.0444324,0.07153277,-0.038220715,-0.04427117,0.0019140014,0.044688486,-0.005597527,0.03795142,-0.02559031,-0.044462103,0.008758175,-0.027591025,0.026504,-0.067452036,-0.050593097,-0.05422567,-0.030130526,-0.04362365,-0.021548703,-0.042088017,-0.0829196,0.06361359,0.0011550704,0.11367216,-0.028393356 +2.7.1.110,Phosphorylates and activates EC 2.7.1.109 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase that has been inactivated by EC 3.1.3.16 phosphoprotein phosphatase. See comment on EC 2.7.1.37 protein kinase.,384,1.0,-0.086299874,0.036417533,-0.034250602,0.0066598067,0.04811554,0.017792901,0.0092666745,0.011553526,0.028633468,-0.01972569,0.014523997,0.0013631625,-0.037018426,0.0029676564,0.004088531,0.019268367,-0.05430589,-0.0036298602,-0.052307863,-0.03678203,0.014810509,0.016874937,-0.036566947,0.064611465,0.009310382,-0.028184788,0.07453929,0.0016890751,-0.07680253,-0.086387046,-0.016834736,-0.03822863,0.06572586,0.006860378,-0.011961955,0.0793079,-0.003859276,-0.14327979,-0.098402575,0.052663386,0.07150935,-0.03965719,-0.02469781,-0.05206813,-0.033241324,0.020949997,0.014026107,0.05973515,0.052359134,-0.024582285,0.0034616115,-0.038513813,-0.02604768,0.04722534,0.014241629,0.014619203,-0.04630792,0.039549444,-0.037607193,-0.03509152,-0.025444875,-0.05897245,0.07795933,0.032264777,0.008697861,-0.030469017,0.07954389,-0.1066374,0.0022955567,-0.00014457598,-0.09006932,-0.050963625,0.08185376,0.04734214,0.05240512,0.039293468,-0.0247365,-0.044291344,0.054713503,-0.06501095,0.033288587,-0.06767673,-0.04585569,0.052343342,-0.009011161,-0.011998899,-0.025701847,-0.038207162,-0.047414534,0.021382377,0.037008833,-0.09072523,0.070972174,0.019833965,-0.080340415,0.0877506,0.016422715,0.033994325,-0.039086815,-0.02612164,-0.027306555,0.13811202,-0.040541314,-0.022672053,-0.010231052,0.025842208,-0.013062544,0.06061778,-0.05542401,-0.014309826,0.02048446,-0.06671528,0.05613859,-0.012435105,0.00032271844,0.10513308,0.01742493,-0.07389059,-0.05102348,-0.024897765,0.051896106,-0.036364187,0.020156983,0.019000422,-0.05066796,0.034919575,-0.08787525,3.1479926e-33,0.01239175,-0.022777509,0.0667125,-0.0030528093,-0.038973916,-0.02906293,-0.0443117,0.0039441437,0.020793876,-0.17161407,0.022234058,-0.006396538,0.10457824,-0.024222722,-0.03153759,-0.045082867,0.021487141,0.02978631,0.015737614,-0.030997045,0.102444805,-0.015834713,-0.034806594,0.013604263,0.01939432,0.05161925,-0.09342577,0.010431841,0.008847765,0.050195146,-0.027925352,-0.016738398,-0.06149697,0.06018309,-0.040470276,-0.04524158,-0.07174342,-0.06642896,0.024059137,0.06811985,-0.017278317,-0.03020236,-0.045409646,-0.045845773,0.019203221,-0.059499294,-0.03564912,0.11632591,0.081303,0.050940853,0.002872531,-0.055545487,0.103381835,-0.034854475,0.05002162,-0.0076734666,-0.056321982,-0.06592746,-0.018404806,-0.01540694,0.016932499,0.09463497,-0.08038741,0.05775721,-0.039211243,0.04067402,-0.10113807,-0.05521277,-0.068652146,0.01952588,0.01463502,0.05638111,0.09326057,0.022985065,-0.038549412,-0.0011208855,-0.0023473282,-0.0070813266,-0.09897532,0.12200701,0.011736762,-0.013761978,-0.027015906,0.03306574,-0.0167129,-0.013744425,0.12180132,-0.037000507,-0.029819751,0.0065448238,0.037039537,-0.056069534,-0.043793317,0.008825895,-0.0108687645,-4.858824e-33,0.10501336,-0.0051054386,0.0027537884,-0.053987976,0.03163471,0.025782852,0.08981045,0.01197355,0.011128051,-0.062030997,0.045523807,0.0078124935,0.003952431,-0.025904024,0.08105916,-0.025623815,-0.04390345,0.02554176,-0.034422006,0.0033656769,0.022588184,-0.045267705,0.015575046,0.11267196,0.037849378,-0.09587945,-0.06757448,0.04963874,-0.025841122,0.033443063,-0.06768716,0.018317929,-0.015365597,0.01647858,0.019525822,-0.010365956,-0.100058734,-0.01573649,0.02551605,-0.045255944,0.0036434939,0.03359716,-0.007972978,-0.034701925,0.09804598,0.11781968,0.02784454,0.097923875,-0.0051676375,-0.046626024,-0.0072351326,0.052399408,-0.015144429,0.09491486,0.013338927,0.045365855,-0.012301034,0.13493302,0.08063776,0.008917728,-0.035644915,-0.05639153,0.015091555,0.054932307,0.051118,-0.0155465705,-0.03050738,0.05053472,-0.010204463,0.057785373,0.07076847,0.039824806,0.035401106,-0.008035426,-0.028727941,-0.044733014,-0.08658912,0.005247028,-0.061594244,-0.050428603,0.015094763,0.0127980355,-0.005791629,-0.047746543,0.03181239,0.033985343,-0.02187709,0.009268136,-0.040570214,0.007963148,-0.09320125,-0.066119604,-0.11091964,0.05819515,0.009561697,-3.87906e-08,0.029580522,0.008671734,0.044697527,-0.06036502,0.11647675,0.041781735,0.034043435,0.048733994,0.034262057,0.0072442982,0.036393534,0.035756774,0.10308878,-0.034880485,0.028572628,-0.000734749,-0.0014369893,0.04494371,0.020556165,-0.045124885,0.041293927,-0.09346424,-0.08068812,0.065731645,0.029486826,0.03729457,0.03807163,-0.000949406,-0.017006833,-0.12855712,0.04616629,-0.03830615,0.06988118,0.018306222,-0.023075918,0.023927838,-0.06477618,0.028780403,-0.07656037,0.06827946,-0.03423293,-0.025245206,0.011973938,0.020448366,0.026914557,0.0071172696,0.06523174,-0.002053284,-0.029930893,-0.06455672,-0.01699678,-0.01939765,-0.05489176,-0.064862005,-0.04082167,-0.06329347,-0.03295346,-0.031404305,-0.005286623,-0.034993056,0.09752551,0.04044736,0.086298004,0.033125546 +2.7.1.112,"There are many eukaryotic genes for this type of enzyme, some of which are closely related. Nucleotides other than ATP may also act as donors. See comment on EC 2.7.1.37 protein kinase.",384,1.0,-0.075993635,-0.02761373,-0.074939646,-0.041996416,0.01349088,-0.02063904,-0.060154907,0.016992848,0.021973427,-0.019344272,0.050112594,-0.09671403,-0.107844226,0.047106113,0.015465022,0.03678912,-0.11248445,0.023536364,-0.014874545,-0.060408637,0.031115513,0.02109567,0.034101043,-0.004120726,-0.032279022,-0.010510051,0.09829427,-0.0013773731,-0.01759107,-0.058919586,-0.11594116,-0.10956269,-0.015114238,0.014956718,0.0061673163,0.10272258,-0.11113333,-0.045494646,-0.0024491495,-0.004400717,0.11386231,0.0067546684,0.035885293,0.025636392,-0.07876434,0.022383412,0.016790485,0.016795443,0.0035356558,0.002780074,0.006148293,-0.03215427,0.00082508347,-0.049808823,0.01719974,0.03420091,-0.02162903,-0.004498071,0.021243578,0.0060423547,-0.00070948264,-0.017623508,0.023228094,-0.03289608,0.054695893,-0.03216459,0.054286763,-0.032863133,-0.02605004,-0.06884949,0.011946958,-0.117865406,-0.008136437,0.08650749,0.001249998,0.07545915,-0.019349175,0.029841678,-0.008277098,0.016395578,-0.020695852,-0.012176235,-0.004397994,-0.031085579,-0.025974404,-0.04258419,0.036910944,0.06865798,-0.015021513,0.050804827,-0.036425196,-0.006183142,0.030808924,-0.057297748,-0.06518122,0.02962619,0.08607316,0.07624078,0.015646754,-0.072106846,0.042387437,0.095407106,0.042681225,0.008845297,-0.01021011,0.03789793,-0.0054036425,-0.027362952,0.020407394,0.0011725819,-0.057566248,0.026761064,0.038526427,-0.05005896,0.0041859117,0.051718444,-0.09104998,-0.050624266,-0.012693343,0.059701767,0.009169922,-0.05237442,0.007935211,0.07066125,-0.008464818,0.038887177,-0.1584958,-1.0444975e-33,-0.008851495,-0.0119577395,0.0054870513,0.008856566,-0.020254953,-0.0414072,-0.021469507,0.019821553,-0.10008594,-0.11643787,-0.08193433,-0.068588816,0.0844102,-0.0021969879,-0.09812092,0.009607101,-0.02163812,-0.034384403,0.016478261,0.04191402,0.025468806,0.048864014,-0.03936181,-0.010391974,0.01997531,-0.0033471982,-0.037412096,-0.016879555,0.04217865,-0.008042714,-0.008740609,-0.0845883,-0.039947867,-0.030301267,0.06303285,-0.030648556,0.027607935,-0.05573135,0.018050354,0.013700574,-0.036633678,-0.018948527,-0.014843844,-0.019767746,0.08215692,-0.054722738,-0.052752044,-0.0097820265,-0.062383264,0.001917379,0.022743555,-0.103096366,0.09244225,-0.058947127,0.0068868715,-0.031288017,-0.004738186,0.027925842,-0.012918546,0.0751503,-0.008308863,0.047418118,-0.035958927,0.037815433,-0.013939309,0.024780395,-0.043416265,-0.0353988,-0.03731434,0.096649036,-0.041178163,-0.024850708,0.021432117,-0.03481964,-0.020237572,-0.022457415,-0.0054536904,0.002258694,-0.026405878,0.11768989,-0.052032374,-0.02881166,0.050779898,-0.058933444,-0.03165912,-0.049020257,-0.033397783,-0.054712955,-0.0024710877,0.0063203447,0.07207737,-0.06765209,-0.090951145,0.01619733,0.060977213,-4.6400593e-33,0.09014906,-0.052454744,0.04452833,-0.09690136,-0.033695485,0.07507054,0.01417411,-0.06332549,-0.019638216,0.014978138,0.071170755,-0.042855464,0.05063759,-0.050040442,0.046601616,0.030759033,-0.09004269,0.12469193,0.0059961258,0.004077834,-0.030333582,0.072042994,0.06345405,-0.0028456254,0.005725305,-0.021490395,-0.09153435,0.12902774,-0.009135035,-0.026490701,-0.102687575,0.025802184,-0.0010440298,-0.055381976,-0.009603411,0.01960489,-0.0016877655,-0.025516512,0.041857537,-0.010525203,0.029817777,0.08631538,0.046988145,0.0716602,-0.026259098,0.016393999,0.0034290086,0.015545649,0.027470538,-0.07153081,0.004766148,0.044030312,0.0040143826,0.039798174,0.007226068,0.03723047,-0.0018110074,0.064814374,0.01588251,0.005704129,-0.041392308,-0.100911565,0.101346344,0.050262854,0.056540687,-0.010299327,-0.0647171,0.014699189,-0.021565866,0.008524547,0.039674878,0.01009095,-0.036638156,0.06503621,-0.0189748,0.0024657054,-0.060177222,0.018176671,0.018136716,-0.06031123,0.035616484,0.056188677,-0.039079323,-0.01752692,0.04252858,-0.029690571,0.07285712,0.038344532,0.0088123735,0.017839396,-0.023531673,-0.0075139008,-0.025120236,0.054375887,0.02740655,-3.8704812e-08,0.05378445,0.015795166,0.038462173,-0.04873243,0.066345446,0.02955795,-0.060909256,0.040724102,0.060622636,0.07814945,-0.036968254,0.07663352,0.019568773,0.03776059,0.08044414,-0.0064636567,-0.0760731,0.02204409,0.021747652,0.027855419,-0.026932351,-0.08282693,-0.06392763,0.12778266,-0.015830312,-0.028509134,0.092127144,0.04900642,-0.00045158493,-0.08772745,-0.05694644,-0.05931897,-0.032021705,-0.071051694,0.0030123652,0.082901284,-0.009669928,-0.061944086,-0.06891549,0.018741814,-0.007235359,-0.0795234,-0.069195725,0.027003793,0.039868888,0.061388023,0.054152,-0.020662775,0.002450682,-0.04970161,-0.022407874,-0.06189537,0.006788326,-0.11910415,-0.08276041,0.0026090704,-0.031933635,-0.005649087,0.09201095,-0.040368855,0.042107135,0.03758018,0.21034846,-0.035608888 +2.7.1.113,Deoxyinosine can also act as acceptor.,384,1.0,-0.08425703,-0.046676964,-0.05403068,0.026339268,0.014680479,-0.07884156,0.054892853,0.046627503,0.03180214,-0.03460181,0.083114855,0.023974145,-0.03137169,0.09589136,-0.012015699,0.076128334,0.01573817,0.06758337,-0.0006243538,0.013795834,-0.033972826,0.04210031,-0.036492698,-0.033343304,0.0065201567,-0.019642442,-0.018665897,0.05795212,0.027758364,-0.044958048,0.002954369,0.02692818,-0.02299992,0.021830138,-0.017816277,0.06878798,-0.09995088,0.03290946,0.06499175,-0.011037588,0.0062315376,-0.023244621,-0.023548845,0.0017305558,-0.03247649,-0.07276141,-0.042158503,0.048156235,0.034949895,-0.03972659,0.041546512,0.026683224,-0.03749511,0.07157432,-0.040655386,0.009795974,-0.1042743,0.019091731,-0.008678585,-0.010580464,-0.027601661,-0.025398044,-0.019223796,0.043211464,0.011208298,0.012036371,0.061996825,-0.025324533,-0.0031651205,-0.008982238,0.038564865,-0.035737757,0.02628091,0.023458984,0.055525377,0.025502052,-0.051527433,-0.03054222,0.021468122,0.091755524,-0.00514491,0.041712,0.098258406,0.055514876,0.07682155,0.0006802263,-0.06891603,0.014042509,-0.07856128,0.053415336,0.002680121,-0.029225633,0.040090907,0.005370608,0.05007493,-0.066905476,0.028998118,0.050718665,-0.07159763,-0.01467691,-0.0992772,0.039149195,-0.10892168,-0.04837231,0.0144140525,-0.015004906,0.10818218,-0.09984619,0.014153249,-0.03786856,-0.046615705,-0.09738001,0.068857744,0.0043588793,-0.052052252,0.1038296,0.01964547,-0.009330193,0.02754588,-0.07457646,-0.02345159,-0.012536084,-0.018839726,-0.0717556,-0.03949205,0.022891995,0.05648672,8.464505e-34,-0.025976498,0.0230505,0.019759063,0.04299029,0.020307302,0.015925033,-0.015198897,-0.01165189,-0.0011637708,-0.050155982,-0.14794537,-0.028145265,0.044976633,0.08665671,-0.06475979,-0.006475861,-0.016336001,0.041415956,0.043725222,0.018855345,0.056766663,0.03601629,-0.081646994,-0.03371942,-0.068625525,0.03594957,-0.0379087,0.08483747,0.041997086,-0.0067093596,-0.0074903946,-0.0647834,-0.03988709,0.06373592,-0.023161024,0.03406994,-0.039013118,0.0021519787,-0.0077522597,-0.04793996,-0.087107934,0.028715162,-0.12719941,0.010514549,0.0425906,-0.011941761,-0.06552268,-0.037898708,-0.057161987,0.07060109,0.04381925,-0.015929524,-0.014246823,-0.087398805,-0.020414915,-0.059097324,0.049136117,0.041498728,0.018825734,0.08858892,0.0008751417,0.03555053,-0.03347763,-0.0047897627,0.02272378,0.052936096,-0.090851635,-0.06727341,-0.070545524,-0.028525893,-0.050093938,-0.008635445,-0.0062014926,0.025028877,0.043484494,-0.041230977,-0.022219585,0.020584458,0.07653154,-0.037342265,-0.016729554,-0.11778998,-0.023740908,0.0130702425,-0.061047513,0.010353977,-0.0038185914,-0.061179418,0.0691727,-0.012543188,0.012595036,-0.036903556,-0.046287872,0.01492867,0.10223156,-2.4149701e-33,0.040266704,-0.039194047,0.014974462,0.007918364,0.023053821,0.11320156,0.048434045,-0.07734354,0.15865777,0.009504989,0.08775885,-0.010140714,-0.029911,0.03419803,-0.029389884,0.06802834,-0.0630929,0.056377545,-0.07462398,0.020974247,-0.0309098,0.100985095,-0.019891163,0.031927552,0.011129457,0.032999657,-0.009490873,-0.026448848,0.047177233,0.050180092,-0.05237809,-0.0060477355,-0.045415353,-0.013009579,-0.0277504,0.04693584,-0.02263756,-0.004859869,-0.083691314,-0.08203346,-0.023160469,-0.026025074,-0.02280788,0.20989335,0.05217303,0.02789215,-0.00083710405,-0.04389848,-0.02147151,-0.01875111,0.007718019,0.06981309,0.0077657546,0.027140161,0.045637067,0.08809193,0.08679486,-0.08885139,-0.024156319,0.006026296,-0.013528093,-0.04244941,0.018475994,0.01781392,0.037217382,0.013121538,-0.071833305,0.10109375,0.05180992,-0.06323097,0.108069025,-0.060412154,-0.023803225,0.041120127,-0.03117155,-0.030567057,-0.005762014,-0.06357995,-0.032556437,-0.018339183,-0.1271486,-0.002694376,-0.0064851996,-0.02641581,-0.011438621,-0.07049527,0.012034683,-0.04953222,-0.115154296,0.062092997,0.0053708195,0.017825535,-0.03006912,0.06355343,0.08239667,-2.0150942e-08,-0.032384124,-0.056074284,0.058452174,-0.022977868,-0.045217983,-0.009472333,0.052449983,0.0069039003,-0.012526312,-0.011142049,0.013205295,0.13257575,0.023126313,-0.0040635797,0.060917802,0.031833388,-0.022155838,-0.015230212,-0.025695479,-0.020614708,-0.039640028,-0.036228336,0.0015776508,-0.041006062,0.006063086,-0.0450051,0.040297937,0.0936659,0.0062830034,-0.01043206,0.015348293,0.0067860703,-0.019379502,-0.052422125,-0.0074085356,0.02711529,0.022915155,-0.029991474,-0.02949139,0.0009189366,0.0071684476,-0.029132113,-0.072735995,0.022265794,0.016153285,0.054148607,0.04288524,-0.0005336983,-0.02260676,0.004640792,0.1016736,-0.038750656,0.060711302,0.008414298,-0.064582504,0.07098417,-0.04043367,0.027879002,0.051275317,-0.05918511,-0.05935011,0.02389622,0.18490273,-0.0013489857 +2.7.1.114,"The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP kinase).",384,0.99999994,-0.10321219,0.033773113,-0.051910598,-0.032767903,0.08063121,-0.016146336,-0.029307235,0.08107593,0.005709626,0.08913848,-0.0005591043,-0.062028337,0.014603367,-0.031286124,-0.0046434947,-0.006014357,-0.10549741,0.045162953,0.013773217,-0.042439897,-0.07593697,-0.009820943,-0.005784422,-0.029220318,-0.07536778,0.13279362,0.0033147184,0.16114943,0.030531263,-0.053844552,0.0051333033,-0.10210685,0.068735704,-0.01948063,-0.026228165,0.10114328,-0.085672416,-0.085209556,-0.0104008755,-0.017784577,0.054436933,0.029572772,-0.014683405,0.011914781,0.028660009,0.0008348655,-0.00840788,0.022425685,0.006669482,-0.030282415,0.065126196,0.0791712,-0.0015027361,-0.019331587,-0.09251059,0.018079935,-0.12006513,0.05151823,-1.0068357e-05,0.03505366,0.046892956,-0.02935988,0.054633874,0.009215738,-0.008823618,-0.014851,0.054602347,0.016855825,0.065463595,-0.037548922,-0.07188935,-0.011356749,-0.0147648845,0.09555795,0.0033622822,0.025655253,-0.02691642,-0.057205673,0.033206396,0.023019642,-0.0684912,-0.113293864,0.019348377,0.050299965,-0.07611328,-0.038466338,-0.02390619,-0.036057673,0.088042215,0.03926653,0.045162294,-0.0268533,-0.02435592,0.008778158,-0.006419562,0.082652606,0.050296526,0.14532077,-0.020996926,-0.054818984,-0.027095411,-0.008547911,-0.09399849,-0.004758945,0.08551399,-0.05742765,0.07090906,-0.017742136,-0.0019190138,-0.03259898,-0.029533157,0.007198871,0.07834217,-0.034092862,0.038202703,0.10804907,-0.046662383,-0.076437,0.029170856,-0.027419074,0.042083684,-0.04401363,0.008694878,0.07382582,-0.054272845,-0.0048456946,-0.021169951,2.7580585e-34,-0.030498374,0.10177228,0.04407301,0.02419399,0.00569519,-0.0057441504,-0.016678268,0.023850344,-0.04030124,-0.04415807,-0.07720446,-0.01892797,0.11290453,0.05049998,-0.095710345,-0.050227042,0.006199846,0.01754131,0.009898357,-0.014253146,0.10609507,0.094924375,0.04014723,0.015075989,0.032620568,0.034727775,-0.019629296,0.037338037,0.029310608,0.0017902658,-0.09760088,-0.038778402,0.0076372386,0.047699362,0.019304752,0.044387423,-0.07121629,-0.00938073,0.07652527,0.07201544,0.0050005354,-0.03816028,-0.04801418,0.015811669,-0.0143587245,0.059634224,-0.0121488,0.027269516,0.003354211,-0.04342489,0.015422309,-0.042347014,0.010241261,-0.034647185,0.020143649,0.047142453,-0.009174051,-0.02141496,0.037906744,0.04732294,0.0019676988,0.05771287,-0.047154512,0.042044535,0.0203328,-0.015595571,-0.0060174842,-0.015870133,-0.005819928,0.01410933,-0.021198887,0.095011726,0.1132919,-0.08141657,0.0814371,0.07593206,-0.030518727,0.016956137,-0.060902584,0.035549693,-0.03617957,0.02207527,0.035246126,0.0073607466,-0.025019145,-0.03573129,-0.057268627,-0.040729955,-0.00906898,0.036895048,-0.027867058,-0.027452482,-0.005355036,-0.04413919,-0.051965147,-1.8274575e-33,-0.0010698348,-0.045912586,-0.01553984,-0.018518247,-0.020615248,0.09414119,0.08343109,0.0023380183,0.11362347,0.0024219046,0.066066355,-0.08020201,-0.0051115593,-0.0717525,-0.05478836,0.006184911,0.027871992,0.11966795,-0.043105338,-0.029803135,-0.014235728,-0.016651457,-0.0038255295,0.06857596,0.03917683,-0.042797547,0.029600075,0.016518284,-0.0042369426,-0.023132069,-0.009460517,-0.01815847,0.009691136,0.051185947,0.037047304,0.04482712,-0.093314976,-0.07797886,0.005869403,-0.12566876,0.019270567,-0.06818252,-0.019939458,0.002734394,0.029405324,0.084259875,0.005196219,0.035759248,0.01408395,-0.036381543,0.0068598897,-0.04383382,-0.07802691,0.05982876,0.04155388,0.017986475,0.0064212736,0.039877728,0.030858535,0.03616068,0.015176783,-0.07123214,0.013148795,0.009320444,0.028277671,0.025926104,-0.05671974,0.009957942,0.007858273,-0.0014013273,0.085454114,0.032807223,-0.010816281,-0.034658737,-0.04837966,0.00089697016,-0.03241609,-0.019659333,0.041398462,-0.07577392,-0.038024962,0.006313662,0.0122016715,-0.05563131,0.024994735,0.09490723,-0.05496182,0.058858287,-0.01968226,0.0078028385,-0.059564162,-0.0631734,-0.043754794,0.0368363,-0.0046612862,-3.293509e-08,0.07428568,-0.031414166,0.022460608,-0.0022636072,0.02506229,0.105615504,0.00045926913,0.029552944,0.030180704,0.017288614,0.08559008,0.019647976,0.05692195,-0.046810944,-0.049857456,0.035138056,-0.05846696,0.06370497,0.015934,-0.08255879,0.010689874,-0.026135584,-0.059909463,0.02488828,0.06943331,-0.053672146,-0.017218411,0.023699895,0.116360806,-0.17863071,-0.026883634,-0.08281948,-0.05547292,-0.013044958,-0.0074423063,0.012315191,-0.050824434,0.033560425,0.03320668,0.015355599,-0.0056729335,-0.05229724,0.0074493852,0.0065905303,-0.08594569,0.08290093,0.034163784,-0.011836279,0.000719602,-0.07170688,-0.014912797,0.021730507,0.001147605,-0.07313944,-0.10888481,-0.011120712,-0.07453983,-0.06047865,0.004595735,-0.077726565,-0.029790808,0.0112489695,0.07426979,0.057852775 +2.7.1.115,A mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). See comment on EC 2.7.1.37 protein kinase.,384,1.0,-0.047835287,0.036446776,-0.04572266,0.0021425092,0.098511726,-0.05614891,-0.07779673,0.011018537,0.034437735,-0.020549573,0.092347324,-0.059145134,-0.012419859,-0.04929207,-0.0028370966,0.05990545,-0.114693835,0.048838325,0.013402725,-0.05594527,0.03627396,0.022497647,-0.0066881003,-0.005727907,-0.0022873813,0.0022635735,0.059566956,0.056029785,-0.06337604,-0.0856468,-0.0030596838,-0.06945921,-0.030070055,0.015910182,-0.025215792,0.16017918,-0.009197631,-0.09178543,-0.015316196,-0.0068817344,0.12330014,0.04151452,-0.0070424615,-0.03855086,-0.022996098,0.0065407567,0.014951854,0.010335658,-0.0063001635,-0.012053818,-0.004491745,-0.06277203,0.00041046873,0.06401474,0.022452453,0.067982726,-0.010760713,0.0050777406,-0.040350396,0.058236375,0.015488424,0.0013249654,0.016800072,0.009152393,0.017510297,-0.036340915,0.05540485,-0.06533782,-0.0040733786,-0.05917878,-0.0707622,-0.07590009,0.025693672,0.06538699,0.0012947539,-0.012111812,-0.075442694,-0.034229696,0.051688008,-0.08936003,-0.0031286427,-0.059852522,0.008302869,-0.023561213,-0.017169956,-0.026269263,0.012935236,-0.04858505,-0.014541779,0.062673956,0.023914479,-0.03888399,0.014268627,-0.020947715,-0.046689898,0.058715712,0.0616158,0.14623871,-0.086730815,-0.03702701,0.011714925,0.109716006,-0.024692478,-0.054218486,0.0059245694,-0.006923828,0.030492902,0.031719193,-0.036280308,0.005053353,0.0060009854,-0.013163117,0.040662583,0.030436294,0.016500013,0.15024544,0.01597921,-0.06314731,-0.036592584,-0.024055732,0.037334245,-0.024073116,0.02447582,-0.0035729797,-0.082084715,0.02905758,-0.11337009,2.2158895e-33,0.013557574,-0.010597591,0.035290286,0.033407692,-0.008017845,-0.06328648,-0.093293294,0.008177998,0.050560378,-0.10789766,-0.040431403,-0.0138283055,0.05576492,0.009515486,-0.0040067392,-0.06248025,-0.007421076,0.032856185,0.09623517,-0.00029170045,0.038887404,0.025799803,-0.014585505,-0.047976118,0.048691284,0.059069254,-0.03459098,-0.04778969,0.07975481,0.049486224,-0.024377001,-0.092229135,-0.08582622,-0.001290534,-0.026377346,-0.06337542,-0.06833349,-0.054710217,0.012581365,0.04184585,-0.045601822,-0.06437646,-0.014048715,-0.02457128,-0.0072527803,-0.05861156,0.045194346,0.052385297,0.0422152,0.053227454,0.02049851,-0.09747118,0.068987295,-0.08077257,-0.027683256,0.008114499,-0.05239964,0.010389351,0.0004448664,0.07112611,0.04741018,0.06740817,-0.023989098,0.0657668,0.06843812,-0.018237308,-0.10119896,-0.105865166,-0.051382784,0.003093709,-0.031796273,-0.009894629,0.12723762,-0.0128002325,-0.004386443,0.009445536,-0.06226704,-0.0016947642,-0.051549867,0.06588465,-0.016692935,-0.0007967377,0.010629398,-0.005188384,0.059964035,-0.014170881,0.029726157,0.00025562756,-0.0675005,0.05008662,0.02448792,0.00022505118,-0.04947846,0.010486625,0.08052146,-4.351629e-33,0.07562318,-0.034961343,0.060670465,-0.089921586,-0.006678156,0.09977304,0.031742163,0.01009307,0.0022919413,-0.0063233306,0.0785902,-0.00327599,-0.005410771,-0.07647825,0.0789373,-0.030658722,-0.05990844,0.070000775,-0.007101396,-0.019695459,0.09392301,0.046496525,-0.0028461327,0.08654723,0.03738207,-0.0031668914,-0.036476668,0.019507056,-0.00017403536,0.013617653,-0.07171758,0.048500627,0.032112338,0.0067068907,0.00422345,0.027007716,-0.04617516,-0.046773713,0.013797212,0.040990286,-0.014333572,0.051866975,-0.010461345,-0.021959495,0.048576426,0.026211828,-0.105160505,-0.0035782151,0.010600486,-0.07586592,0.037277624,0.045830514,-0.05924421,0.009314705,0.047394697,0.037627194,-0.02028874,0.117950246,0.05151545,-0.049960267,-0.09272413,-0.06826468,0.04031539,0.023218635,0.03457488,0.0019575395,-0.021278106,-0.024229534,-0.010714978,0.057306215,0.055196457,0.03908969,-0.055271413,0.0019145044,-0.035694275,-0.018266542,-0.04882617,0.003144819,-0.02122291,-0.06732189,0.017807323,-0.0067671984,0.017178694,-0.072060905,0.007378621,-0.049467225,0.018575922,0.06122031,-0.032899905,-0.017923266,-0.0046748077,-0.06738731,-0.1460601,0.09604761,-0.012264497,-4.052888e-08,-0.022051308,-0.011874579,0.09270701,-0.028678384,0.09172098,0.038564112,0.0197672,0.05887386,0.02163929,-0.0050336295,0.050886076,0.067349434,0.066050075,0.00012749781,0.03566048,-0.0018432506,0.0037241452,0.055889156,0.010797112,0.002109003,0.043284133,-0.07736296,-0.09956271,0.08630536,0.052712314,-0.0274809,0.040709306,0.021708645,0.026686242,-0.086289,0.024055965,-0.016720975,0.007513246,-0.02561278,-0.03296792,0.0003796677,-0.051747516,-0.03722334,-0.10774523,0.06268673,-0.010212932,-0.034237783,-0.022315038,0.039127223,0.046232916,0.05413212,0.047823057,0.027700195,-0.037394132,-0.012909889,0.031254824,-0.009755116,-0.0051010717,-0.0679305,-0.14013766,0.0003278773,-0.03768007,-0.074502684,-0.03307411,-0.05876539,0.12856238,0.053981967,0.11149404,0.016867606 +2.7.1.116,Phosphorylates and inactivates EC 1.1.1.42 isocitrate dehydrogenase (NADP+). See comment on EC 2.7.1.37 protein kinase.,384,0.99999994,-0.07332616,0.02169117,-0.031655177,0.022254955,0.057207607,0.029879767,-0.044844102,0.02228015,0.043701574,-0.0019566908,0.064295374,-0.03317047,-0.08510013,-0.017991165,0.0006524508,0.007191079,-0.020029675,0.022780355,-0.0004042004,-0.054084376,0.013187288,0.03161771,-0.005634704,0.027119251,0.045424547,-0.0047304826,0.016693883,0.058238722,-0.059592944,-0.09985944,0.002181837,-0.062944666,0.053042874,-0.0034639863,-0.040823206,0.092069454,-0.026713202,-0.10046119,-0.0045915022,0.04552357,0.059535354,0.008326839,-0.06773639,-0.040025,-0.06529876,-0.0059253927,-0.01034276,0.06526458,0.007918616,-0.020910202,-0.0008733717,0.0054222164,0.0066214795,0.02088249,0.0069490015,-0.02674235,-0.03422631,0.06367378,-0.054717004,-0.06425577,-0.038935784,-0.064967714,0.07101228,0.06132924,0.05499234,-0.052174088,0.11409331,-0.084679805,0.020886116,-0.00022048573,-0.12683429,-0.039317556,0.05112309,0.041976295,-0.021300834,0.06219536,-0.10545993,-0.033165947,0.059691507,-0.073685974,0.05768467,-0.040793054,-0.050272427,-0.0011303681,-0.014620095,-0.0035755113,0.038027905,-0.007021736,-0.035124555,0.015862383,0.02103767,-0.04328221,0.0028430254,0.019189471,-0.08993658,0.03085854,0.05781332,0.084110506,-0.06643464,-0.067995325,-0.021150205,0.14454834,-0.062336802,0.016547753,0.017629862,0.004483248,0.016298547,0.07361032,-0.0650094,0.018049646,0.021506306,-0.061862398,0.05951108,0.0062453826,0.039385386,0.09732055,-0.010904271,-0.05547401,-0.010592991,-0.058058366,0.056946237,-0.092092946,-0.012619387,0.028700404,-0.104172945,0.05622017,-0.08007828,1.5212186e-33,0.04058365,-0.019853279,0.039812375,-0.024397958,-0.001451479,-0.034681864,-0.04414538,0.036518775,-0.019072203,-0.09007856,-0.028120274,-0.029294986,0.10297804,-0.018747728,-0.03802482,-0.034759495,-0.011298748,0.012363924,0.044053428,-0.018371636,0.049536664,0.017289534,-0.041727666,0.0048668324,0.03336892,0.069023274,-0.08806405,0.03193035,-0.041119087,0.0133633595,-0.008342017,-0.038330227,-0.10857428,0.036524557,0.008314138,-0.046961274,-0.020137813,-0.035461493,0.036719754,0.03940647,-0.038239174,0.0049786745,-0.019232592,-0.07256412,0.007754482,-0.055636045,-0.013026523,0.083017655,0.055307172,0.02829458,0.041192822,-0.054615717,0.08614599,-0.119895205,-0.006895817,-0.016061561,-0.053497594,-0.032828048,-0.042393457,0.10900639,0.0293291,0.09290087,-0.012549411,0.057573475,-0.038365215,0.005754204,-0.13871033,-0.098040804,0.025046207,0.04419601,-0.010439822,0.0622701,0.124218605,-0.041701816,-0.02425424,0.018839518,-0.018734014,-0.0069616493,-0.07277033,0.13549408,-0.04239792,-0.010951545,-0.024705162,0.009563064,0.044813164,-0.00048128824,0.036440354,-0.007187594,-0.013714116,0.033372805,0.023219546,-0.046209536,-0.0029613334,0.00723407,0.019374946,-3.8201792e-33,0.09330621,0.01848031,0.010828743,-0.049659986,-0.0135715995,0.15519486,0.040881816,0.020871356,-0.0012715923,-0.02721464,0.066925995,0.019399697,0.01594635,-0.044457026,0.052686896,-0.04202718,-0.081043474,0.038036056,-0.033523407,0.045293402,0.0120201055,0.040634412,0.022709899,0.0805739,0.051293213,-0.047248106,-0.06026153,0.048107386,-0.032927405,0.002667552,-0.034272313,0.059749536,-0.06684875,-0.005352292,0.021318737,0.011862783,-0.0839046,-0.014991823,0.015182969,0.014921962,-0.0008232637,0.04963861,-0.027974555,-0.017478742,0.108685605,0.049642384,-0.030525632,0.010920889,-0.05022552,-0.044010684,0.012877664,0.071703255,-0.07064246,0.07758023,0.049204346,0.071467526,-0.03895896,0.14471492,0.07445624,0.008334501,-0.03749233,-0.04280844,0.03247221,0.05402117,0.036836054,-0.01895648,-0.020261928,0.020157784,-0.004443289,0.03045089,0.07385479,0.033011094,0.010428501,0.010776628,-0.011605407,-0.025951024,-0.084718294,-0.037857756,-0.06363782,-0.054920014,0.0060416018,0.026195344,-0.035881985,-0.08773034,0.018071959,0.021755692,0.0014220853,0.0075071827,-0.039151233,0.032753505,-0.04428681,-0.043439712,-0.1314557,0.043196283,-0.024043782,-3.2932142e-08,0.04644997,0.012824716,0.055358373,-0.019799197,0.09996516,0.055134308,0.032702133,0.028011736,0.021693857,0.008799154,0.055880032,0.04586725,0.09798013,0.019702597,0.04904306,-0.0019809254,-0.011238991,0.05134074,0.0051481053,-0.015171714,0.008361981,-0.05651098,-0.10738962,0.047754414,0.056774475,-0.03301223,0.027156807,-0.018591661,0.033800155,-0.08954141,0.040595345,-0.020584054,0.07645527,-0.009083514,0.03868745,0.019838942,-0.069980204,0.029567724,-0.093469806,0.09565613,-0.050827403,-0.093347006,-0.025257794,-0.0007227155,0.017478958,0.04716875,0.054195154,-0.028600594,-0.09229195,-0.029123118,0.028719526,-0.014268976,-0.020616325,-0.09044267,-0.037337594,-0.022973996,-0.044979565,-0.07389262,-0.024103887,-0.037831366,0.07395543,0.021604773,0.07467494,-0.0014454436 +2.7.1.117,"Requires Ca2+ and calmodulin. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.",384,0.99999994,-0.0472289,-0.098814994,-0.013096653,0.029535359,-0.04179622,-0.09234059,0.054883625,0.014913703,0.033126727,0.025361545,0.12549292,0.009092275,-0.012951717,0.10469629,0.034725703,0.072610386,-0.023699451,0.029301636,-0.011825239,-0.05151058,0.008824004,0.023654757,-0.030873412,-0.0018738979,-0.09904626,-0.09507418,0.021426262,0.01777013,0.048756033,-0.10809754,-0.077387236,-0.055599604,-0.059327956,0.0051855445,-0.007285464,0.0837617,-0.037068993,-0.038112793,-0.016649738,-0.0048965425,0.074202895,-0.03769338,0.07868748,-0.008254188,0.023659518,0.008773179,-0.0010157331,0.009349549,-0.043119393,0.0008143479,-0.053773366,-0.053855732,0.010444632,0.07226219,-0.00950643,0.09169808,-0.17868954,0.033135764,0.023112811,-0.018979922,-0.031336226,-0.00885938,0.004516989,-0.003905585,0.062417936,0.017370356,-0.05110998,-0.010143829,-0.0013620643,0.033063,0.043464098,-0.05552943,0.010810605,0.05361513,0.040436946,-0.02920531,-0.033461656,0.009745748,0.03337688,-0.000113981194,-0.0045977593,-0.017057024,0.00696875,-0.029002491,0.043549564,0.04500004,0.037824266,0.06626737,-0.08160739,0.045526456,0.09615563,-0.03421767,0.015036126,-0.06598396,0.045741025,-0.0014263069,0.057030648,0.01245051,-0.044619743,-0.03168353,0.07826292,0.005850457,-0.016363874,0.027001953,-0.026415685,0.03146515,0.03494539,-0.0015297653,-0.060592595,0.07424599,0.039093107,-0.012888126,0.033039972,-0.014885774,0.026000755,0.09359328,-0.02543741,0.0015298299,-0.020212783,-0.015942419,-0.04222165,-0.06701225,-0.053797744,-0.0022084347,-0.10502666,0.07522257,-0.058104515,5.502895e-33,0.033088073,-0.047389712,-0.03369133,-0.01678222,-0.043198757,-0.0789514,0.003608291,-0.11475601,-0.07144943,-0.116108544,-0.08896564,-0.03637077,0.02499764,0.10532343,-0.071180336,-0.029977992,-0.0061390596,0.0014413742,0.071701065,0.0331264,0.038433313,0.045857582,-0.01637754,-0.052332606,-0.00923221,0.030556703,-0.060535017,0.06465896,-0.024211401,-0.024350101,-0.020316651,-0.025871357,-0.029853992,0.07335119,0.042478237,-0.0027542824,0.033708125,-0.06499167,0.030737482,-0.049297217,-0.01741438,0.04632164,-0.03408074,0.012676951,0.051495563,0.006339369,0.021857575,-0.056590077,-0.081340395,0.069610685,0.017756185,-0.0013054744,-0.025140569,-0.08978552,-0.0030642923,-0.0440252,0.014329114,0.01343627,-0.039373323,0.085145555,0.012615769,0.0140354335,-0.0009344598,0.0594431,-0.015893705,0.09523044,-0.12347275,-0.024765477,-0.025445025,0.00044073025,-0.030647242,-0.0037803482,-0.036773507,-0.06785496,0.13173413,-0.04374718,-0.03776746,0.0012631716,-0.113676436,0.016810438,-0.0043945215,-0.021935448,-0.08078305,0.1364066,-0.001757139,-0.021149816,0.0505635,-0.02938295,0.016281512,0.0009301046,0.012841771,0.0038626026,0.040662855,0.09488448,0.007990405,-6.765718e-33,0.0996417,-0.05317756,0.14539485,0.019537404,0.022318872,0.09847124,0.07018177,-0.036614697,0.07814595,0.024572562,0.09663647,0.010225439,-0.088507816,0.004658861,0.021631204,0.030032493,-0.056786295,0.08113595,0.019193925,-0.028127598,-0.06755966,0.09053279,0.027523149,0.054008193,0.03262761,0.056996696,-0.043128256,0.03246014,-0.0016542018,0.019121116,-0.0723382,-0.027313361,-0.07383715,-0.04764973,-0.02377174,-0.0068426486,-0.05112822,-0.001831141,-0.02455543,-0.015201127,0.03833196,0.04726497,0.020271651,0.06332469,-0.08266209,-0.011981949,-0.012641859,-0.029202789,-0.1270711,-0.027296249,-0.027834568,0.026601048,0.019530034,0.02640682,0.027106732,0.047006343,0.09086104,0.082277864,0.014629963,-0.012406378,-0.081214435,-0.10166126,-0.025317593,-0.052682053,0.093431555,0.006323554,-0.012082639,0.0025030393,0.004105889,0.03487418,0.058920395,-0.0139020225,0.027876692,0.063518085,0.045858096,-0.026812553,0.0049054394,-0.03441436,0.0769796,-0.05159897,-0.055147283,0.027385382,0.013795959,-0.066666774,0.093168005,-0.017416686,0.04985808,-0.0707081,-0.02060841,0.044013567,0.11682525,-0.014005442,0.010171114,0.008084622,0.010551197,-3.583245e-08,0.030650908,-0.069834605,-0.027722765,-0.06803638,-0.011210086,0.008691025,0.031638924,0.03916144,0.023653835,0.01594637,0.06900447,0.021942493,0.070652,-0.011937357,0.04859062,0.0089552915,-0.05286858,0.007952331,-0.016218442,-0.08406075,-0.09403477,-0.06198045,-0.04800377,0.038628716,0.0072321543,0.026043369,0.06696581,0.09968204,-0.011795343,-0.017758342,0.034487277,-0.035145633,-0.020380361,-0.037051294,-0.05137852,0.0142456675,-0.042375293,-0.050930694,-0.051348995,0.029600035,-0.047913697,-0.017877739,-0.026589928,0.017207842,-0.011808662,-0.016377212,0.005375359,-0.06118805,-0.014083317,0.050334316,0.013380688,-0.06052701,0.011381854,-0.06411598,-0.10586809,-0.02985467,-0.009574646,0.005321524,-0.035915248,-0.024953417,0.06972491,0.041023582,0.10373946,-0.05837383 +2.7.1.118,"The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.114 (AMP---thymidine kinase) and EC 2.7.4.9 (dTMP kinase).",384,1.0000001,-0.09962421,0.031084945,-0.05151936,-0.0392138,0.07256271,-0.0034712157,-0.03387389,0.08079152,0.013678814,0.09770901,-0.006392158,-0.063965954,0.030899044,-0.028400587,-0.0077698445,-0.006534087,-0.104006074,0.04254734,0.0034215664,-0.04846707,-0.07199661,-0.008918037,0.0057612797,-0.030300515,-0.07807389,0.13511868,-0.0019909549,0.15874934,0.033504333,-0.06204976,0.0036716491,-0.09914877,0.067349054,-0.014310839,-0.031596776,0.103357576,-0.092809595,-0.0896604,-0.005072668,-0.011101579,0.05075305,0.022374136,-0.010407957,0.008163482,0.025780875,0.004175055,-0.0027570513,0.018443897,0.011286831,-0.027459994,0.07004315,0.06715981,-0.0038390132,-0.015363917,-0.08093448,0.012786861,-0.124458514,0.057574093,0.004080891,0.038127016,0.052075647,-0.028749095,0.05973221,0.0074032512,-0.019691652,-0.019071246,0.042967904,0.02126508,0.0682369,-0.046202224,-0.06728087,-0.015953854,-0.008466102,0.091352716,0.0068768803,0.027576098,-0.015035061,-0.057420056,0.019953275,0.02755628,-0.07672516,-0.11605884,0.026569407,0.042950083,-0.079520635,-0.029131725,-0.021179128,-0.035089117,0.07917423,0.037241444,0.05599831,-0.030095082,-0.016109608,0.0021900642,-0.0015146832,0.07907722,0.048282787,0.14168973,-0.014222418,-0.05124289,-0.016548647,-0.010751371,-0.09564008,-0.007185029,0.07955145,-0.05578341,0.07694019,-0.013577063,-0.010766715,-0.038004894,-0.026396127,0.008379521,0.074718036,-0.025387125,0.026972506,0.11153622,-0.030645793,-0.07241094,0.019478848,-0.025978832,0.04640228,-0.046090953,0.008727385,0.070922226,-0.067716755,-0.0012027606,-0.027153173,2.6844668e-34,-0.030356817,0.10608941,0.04073665,0.022115057,0.0044986126,-0.0034807683,-0.014177242,0.03080819,-0.04381247,-0.048985288,-0.076548025,-0.0030580326,0.111931264,0.04575663,-0.09651329,-0.052750595,0.0017276914,0.018484168,0.0063719177,-0.020680917,0.10904518,0.08904994,0.051769417,0.015142207,0.030869985,0.034414817,-0.010289161,0.033865023,0.03163101,-0.0029374857,-0.09680958,-0.031732038,0.017714825,0.04541778,0.01989271,0.039388534,-0.06505502,-0.00044184425,0.07310484,0.07641962,0.0011967046,-0.034991175,-0.059510924,0.008730621,-0.018619707,0.048692886,-0.004590548,0.026246345,0.0051486967,-0.044351585,0.0072339578,-0.036532402,0.010774636,-0.035993602,0.023207327,0.049656477,8.237317e-05,-0.024497138,0.03980405,0.038904738,0.0008183471,0.06354035,-0.040417314,0.03688786,0.027251026,-0.02142983,-0.014855161,-0.011475404,-0.012212077,0.014827656,-0.018447088,0.09451862,0.104820676,-0.08890335,0.08554865,0.072428994,-0.04745344,0.012269546,-0.06126586,0.03091782,-0.021007061,0.029053712,0.033192284,-0.00020967763,-0.031749316,-0.0324607,-0.05660248,-0.048433557,-0.016451111,0.040109806,-0.035535596,-0.02732912,-0.0016623421,-0.05324104,-0.050284147,-1.7564738e-33,0.00807054,-0.046010863,-0.019938458,-0.010299775,-0.010234454,0.09165176,0.086030245,-0.0036426703,0.1057076,0.0073713437,0.06389997,-0.07507947,0.00025433736,-0.07338625,-0.05495784,0.00037057925,0.033221383,0.11368991,-0.04667546,-0.03521091,-0.020277934,-0.021820342,-0.00579417,0.06359964,0.031411,-0.036311887,0.028527526,0.018526861,-0.012956639,-0.019951874,-0.017293293,-0.024514385,0.014095357,0.04792126,0.035496358,0.04657467,-0.0900629,-0.07662978,0.007167965,-0.13393438,0.02458674,-0.06884834,-0.014133303,0.006730515,0.028607685,0.07738101,0.0011853847,0.041203152,0.01885081,-0.042217504,0.006249266,-0.045198776,-0.07840992,0.057139777,0.048587453,0.014007159,0.0057102223,0.038327675,0.030735336,0.03592363,0.012081344,-0.08064307,0.0119742965,0.0046199574,0.034333028,0.018365445,-0.06511666,0.014089641,0.019558666,0.001509606,0.09143937,0.031051464,-0.0091666095,-0.040612195,-0.049969316,-0.0042991284,-0.032215584,-0.022432502,0.038897116,-0.07167919,-0.038799398,0.0069594374,0.011313357,-0.0645759,0.04051926,0.09486888,-0.05099609,0.06191503,-0.02249255,0.008181155,-0.05923347,-0.066464804,-0.04147802,0.039874718,-0.0021060994,-3.2830098e-08,0.07217942,-0.041501537,0.015017717,0.008648324,0.026011461,0.1090406,0.0038689445,0.026973568,0.033151153,0.022346243,0.08674662,0.012472019,0.06439315,-0.043472894,-0.042140912,0.036846224,-0.056257907,0.07326767,0.017930511,-0.07893035,0.010240802,-0.025683584,-0.060900226,0.023633022,0.07211741,-0.049629945,-0.021234611,0.024812102,0.10178992,-0.17730868,-0.028220067,-0.08128147,-0.05532471,-0.020150121,-0.00849518,0.012824782,-0.043711886,0.052621726,0.034234736,0.008372014,-0.00039052218,-0.048994154,0.0011901666,0.01406225,-0.09727262,0.077541254,0.033687726,-0.00318502,-0.0008631148,-0.06684547,-0.010149004,0.017981352,0.00485629,-0.07056938,-0.11383412,-0.0070933,-0.071712896,-0.059750132,0.009283131,-0.07997565,-0.02494667,0.007778817,0.07854996,0.053847477 +2.7.1.119,"Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7''-hydroxy group in the destomic acid ring.",384,0.99999994,-0.040241286,0.007117588,-0.091836415,-0.06793901,-0.015825683,-0.00073630014,-0.00018283838,0.031575494,0.070172146,-0.0699098,-0.009824545,0.01393868,0.058755953,0.029712087,-0.0036753148,0.016838329,-0.081987664,0.06620371,-0.03073417,-0.03941784,0.08374393,0.058865607,0.051530007,0.0791316,0.03903793,-0.021791039,0.03774262,0.14956129,-0.081037,-0.11746275,0.044018168,0.027610179,-0.031485595,-0.0026000438,0.049503747,0.053347204,-0.02396604,-0.013138215,0.10351562,0.026723297,0.018163303,0.041575123,0.00854374,0.03213279,-0.035152376,0.042432297,-0.025613617,0.07448191,0.012724257,0.0023218761,-0.02374401,0.0126446765,-0.01755185,0.15932864,0.037419017,0.09367867,-0.089078546,0.016653994,0.035508066,-0.03769775,0.013224348,-0.060463574,0.07831454,0.050414518,-0.094885334,-0.021766772,0.013860436,-0.09130183,0.018310513,-0.0065099727,-0.028285235,-0.016083075,0.060817093,0.026076343,0.02607846,0.0077551603,-0.050920386,-0.026546212,-0.054927453,-0.10954566,0.06997466,-0.01909675,0.028500082,0.1028762,-0.006420083,-0.06040842,-0.023048794,-0.015843416,-0.020154174,0.011803065,0.07056154,-0.019843929,0.042322267,-0.04189946,-0.051935025,-0.03973523,0.024415728,0.05446671,-0.0430546,-0.014650626,-0.04575707,-0.020097796,0.0008842428,-0.01594869,0.022050656,-0.00506118,0.03897355,0.026285619,-0.014165659,-0.042162783,-0.0093155475,-0.0038543362,0.03320398,-0.045480426,-0.0047957324,0.03315877,0.071679786,-0.01750643,-0.040925764,-0.11738239,0.03469923,-0.03304237,-0.033831865,-0.08145485,-0.05817221,0.05833136,-0.08672868,3.160573e-33,0.02588422,-0.017622551,0.019962316,-0.016563758,0.026081152,-0.057450645,-0.041763227,-0.05199785,0.009523983,-0.09696681,-0.052908283,0.009407832,-0.015063154,0.053339396,-0.022151427,-0.029133854,0.05474993,0.058186643,0.007993467,0.018514693,0.055657797,0.101020284,-0.07157552,-0.035671294,0.0239583,0.043824423,-0.007758645,0.018341964,0.084982105,-0.00966459,-0.030059427,-0.05399164,0.023667678,0.03813572,0.027191516,-0.04961909,-0.09540887,0.009027479,0.06511677,-0.03552309,-0.0062140934,-0.010835901,-0.05940002,-0.07488471,0.024481013,0.010853269,-0.0074220784,0.027048148,0.038893312,0.06583838,0.10006968,-0.046112094,0.03302945,-0.026454126,-0.0052501885,-0.00915265,0.004687403,0.041219383,0.021820992,0.018040072,0.037115168,0.0043446897,-0.023955928,-0.022696458,0.1005902,0.027643166,-0.081281856,-0.043910433,-0.03647612,0.011855461,-0.054612584,-0.0056836004,0.038883794,0.06426892,0.03492455,0.05356232,-0.04021818,-0.04575569,-0.0036701048,0.046382997,0.0010127528,-0.009571996,-0.0013444619,0.03440982,-0.039958045,0.029358393,0.04412166,-0.066098444,-0.019377476,-0.016209716,-0.041131727,-0.08508702,0.02330879,0.0057070516,0.051991485,-5.5634895e-33,0.06391335,-0.024518436,0.09660475,0.015811287,-0.023740787,0.16282268,0.0017917895,-0.07413599,0.047265563,0.021831416,0.08318185,-0.0031054248,-0.11686664,-0.05593956,0.036427245,-0.068491004,0.036413137,0.074714094,-0.029839901,0.011470534,0.027171263,0.055275884,-0.0405501,0.029897237,0.013920837,-0.034320578,0.021438202,0.056031812,0.046247438,0.094220676,-0.0075033004,-0.0006864317,-0.052841403,-0.04121449,-0.014316955,0.020906057,-0.08428396,-0.018716924,-0.04103686,-0.061509926,0.011032634,-0.082510084,0.03812373,0.007415371,0.060100235,0.008755333,-0.03786361,0.06162598,-0.005057921,0.022448558,-0.061261244,0.07887826,-0.006435669,0.0013147789,0.005455466,0.0321422,0.0049916874,0.042393442,0.033780314,-0.09205821,-0.09648344,-0.043785673,0.002158268,0.060258944,-0.029403614,0.048568256,-0.07837572,-0.052795064,0.06416823,-0.032079052,0.018736038,0.05969454,-0.005470656,-0.022308104,-0.013825833,0.0067341193,-0.08996728,-0.13533103,-0.0277108,0.0425067,-0.010175794,0.019739032,-0.012368879,-0.04370256,0.026959646,-0.022061124,0.016758068,-0.05104711,-0.02212941,0.029619327,0.07982171,-0.061009005,-0.03358059,-0.016204953,-0.011609597,-3.5607602e-08,0.070122294,0.019047674,0.07069623,-0.0707182,0.003780587,-0.078246064,-0.008003474,0.025116352,0.055226102,0.029106224,0.037952874,0.038056914,0.005385505,-0.04586846,-0.027040757,0.052684978,-0.034786697,-0.0048542437,0.0010408604,-0.04027926,6.444503e-05,-0.060971007,-0.0701851,0.0692135,0.0837168,-0.0060461755,0.012107412,-0.07811463,0.018367337,-0.032043833,0.15204145,-0.050255757,-0.012362221,-0.039661966,0.04270377,-0.067062914,-0.092678726,0.00090209447,0.008436907,-0.009536576,0.043289613,-0.09581756,-0.044766046,0.07620234,-0.035927814,0.055001564,-0.06195495,-0.0045664264,-0.06424027,-0.011431056,0.05308027,-0.014840071,-0.035118215,-0.09785519,-0.1632436,0.038338635,0.040569812,-0.004748776,-0.030376596,-0.058334228,-0.028413216,0.07622696,0.15128653,-0.01717361 +2.7.1.120,Requires Ca2+ and calmodulin. Phosphorylation abolishes the ability of the protein caldesmon to bind actin and inhibit ATPase. The enzyme appears to be identical with caldesmon; the reaction is an autophosphorylation.,384,0.99999994,-0.04163761,-0.04268975,-0.0056323977,0.00034345756,0.0031067142,0.025307864,0.05089389,-0.01851259,0.101213224,0.039277744,0.024708094,-0.026611455,-0.014523124,0.12105798,0.0050554574,-0.036263365,-0.07081177,-0.0073106894,0.06562273,-0.073469944,0.08685775,0.019953264,-0.017642308,0.034092207,-0.048163347,-0.06692951,-0.05504086,0.008151211,0.014347461,0.011822611,-0.06149286,-0.055085838,-0.022096477,-0.03203119,-0.035441265,0.093120284,-0.06465968,-0.0066876234,-0.06679415,-0.0806067,0.09405925,0.036896322,-0.003801758,0.030938566,-0.06445744,0.0253075,0.0049999626,0.014154404,-0.007053545,0.010663083,-0.05873442,0.0049122437,-0.017426787,0.043692045,0.013038933,0.059978016,-0.055352405,0.06521782,0.047214177,-0.024967682,-0.069098696,-0.010491056,0.012473945,-0.01330087,0.10184769,-0.0023519208,-0.032665413,-0.03525432,-0.011876351,0.0836918,-0.013976848,-0.035741795,0.05725277,0.026072564,0.051739927,-0.006760621,-0.058849737,-0.022007754,0.022438731,-0.026764266,0.020118281,-0.065113135,-0.035554703,0.054196104,0.033955894,0.07546545,0.0051506953,-0.023224756,0.03366673,-0.018766593,0.061547812,-0.01517741,-0.005122309,-0.05006759,-0.05411798,-0.0076770657,-0.0052651805,-0.0044088284,-0.03482522,-0.037557676,0.014697223,0.074219964,-0.020969525,-0.016933074,0.028532999,0.058873866,-0.042785317,-0.02776426,-0.08022679,0.03853367,0.051639028,0.018231198,0.066306084,0.04372049,-0.001237686,0.13513659,-0.07188675,-0.047579203,-0.032103647,-0.038869593,-0.041302085,-0.032317366,-0.06041884,0.012538219,-0.05763924,0.031336937,-0.0953431,2.4203228e-33,0.026436646,-0.00021655689,0.012216788,-0.03023279,0.01046708,-0.036377754,-0.021209614,-0.033243332,0.026032465,-0.12244306,0.029666372,-0.057962082,0.03877695,0.028349016,0.0032181628,-0.06370575,0.03486887,0.007259418,0.09662034,0.009178516,0.022683516,0.030694466,-0.020447327,-0.046438474,-0.0046299435,0.1007089,-0.028103128,0.08180908,-0.0069266763,0.010215731,0.008880171,-0.0576963,-0.08643493,0.07504105,0.0626994,-0.027568255,-0.009438331,-0.030042276,0.014527558,-0.018761283,-0.042934295,0.057339367,-0.022405596,0.024287451,0.01840803,-0.064943574,-0.028574618,0.0635657,0.053919587,0.08373588,0.061844558,-0.037219133,0.099612735,-0.091057956,-0.053985424,0.0044947485,-0.0130597325,-0.08510817,-0.0533831,0.005754929,0.046213713,-0.05458275,-0.0027296944,0.060303625,0.029899077,0.068617284,-0.093076155,-0.13030152,-0.030531278,0.046061654,-0.07817558,0.03918764,0.072439685,-0.0033064275,0.04380921,0.00021603216,0.010872454,-0.00797421,-0.09973307,0.0406267,-0.016295627,-0.04831006,0.004981762,0.10897171,-0.023917658,-0.06526392,0.044056438,0.044577826,-0.03939631,0.035105415,0.03646699,-0.06066364,0.018885763,0.15742674,-0.08334203,-2.9832392e-33,0.049553793,-0.059408195,0.12356035,-0.03497521,-0.035489634,0.067038454,0.01136472,-0.08612879,0.057994585,-0.06972366,0.021695215,-0.0058463076,-0.060193494,-0.034397572,-0.012249167,0.08267311,0.0014009529,0.036760125,-0.0019009745,-0.06591135,0.019090375,0.13260181,-0.0009866653,0.07975285,0.058615606,-0.058108088,-0.039779667,0.020644354,-0.02439514,0.05258678,-0.051710438,0.0014851508,-0.053322878,-0.042283546,-0.028787928,-0.0059097908,0.043141264,0.019104669,0.0001495498,0.03246731,0.09200829,0.052721504,0.0015111554,0.09523609,0.060510177,0.06554824,-0.0062877997,0.027709477,-0.08696247,0.05956476,0.009016582,-0.040498838,-0.02173132,-0.009922038,0.039426018,0.07265307,0.052277792,0.06969501,-0.062506974,-0.01737317,-0.029847197,-0.056159873,-0.0013597739,-0.028691879,0.08388774,0.04189498,-0.03434507,0.0043297894,0.030575292,0.03931551,0.08094704,0.061156023,-0.01580556,0.037011456,-0.022493955,0.028381236,-0.018629918,-0.04877836,0.02041312,-0.047139652,-0.07605276,0.09906407,-0.0057028816,-0.025270222,-0.0010991014,0.054413207,-0.008934533,-0.028323118,0.0056688176,0.009188409,-0.026165314,-0.056295343,0.0019312939,0.023043599,0.006062843,-3.3128806e-08,0.0527405,-0.0048606438,-0.05639762,-0.056717258,-0.048701517,0.024195917,0.045696564,0.031534474,0.01669754,-0.008716499,-0.008940945,0.010494939,0.05037791,0.0014197755,0.00792863,0.023894986,-0.008429461,0.058007922,-0.07164865,-0.050663367,-0.016649023,-0.046282593,-0.08366185,0.0845419,0.0036033876,-0.024870789,0.019126108,0.028345253,-0.065188535,-0.011786594,0.012511928,-0.057933677,-0.05932944,-0.056601502,-0.04307906,0.020079112,-0.054660823,-0.076456115,-0.042513732,0.08273738,-0.03548423,0.068359464,-0.02230648,0.030963756,0.012240779,0.026354516,0.009439367,-0.056603268,0.042542946,0.06675072,0.07206427,0.0073233703,-0.034681037,-0.13777477,-0.16242078,-0.03009894,0.03185973,-0.03164841,0.009628431,-0.018585218,0.12531345,0.05853275,0.13679409,-0.07731557 +2.7.1.123,"Requires calmodulin and Ca2+. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase), EC 2.7.11.17 (Ca2+/calmodulin-dependent protein kinase) or EC 2.7.11.26 (tau-protein kinase).",384,1.0,-0.048127137,-0.085061796,-0.016441476,0.018966226,0.072671615,-0.03382285,0.0133315055,0.06789248,0.05304812,-0.049033653,0.04975488,-0.016004195,-0.044689562,0.04565991,0.03333968,0.057279702,-0.03329227,0.020877989,0.0312325,-0.055689443,-0.05625652,0.014092492,-0.0361712,-0.00085748587,-0.10216672,-0.02936294,-0.023600763,0.059928782,0.052246697,-0.06169271,-0.057320055,-0.087470815,-0.05702524,-0.02532493,-0.03680419,0.039573565,-0.07898938,-0.10207445,-0.055999946,-0.07857182,0.12468675,0.0028109928,0.05765971,-0.060355257,0.04251813,-0.035687774,0.045300752,-0.006628716,0.026855351,-0.014285706,-0.043131508,-0.021887504,0.0004401128,0.05832052,0.0115774665,0.10465291,-0.14319931,-0.051063664,0.06780377,-0.010838687,-0.06599616,-0.007617899,0.024468545,-0.055674706,0.03947519,0.0029027553,-0.04017939,0.022569625,0.011242831,0.054425918,-0.011831348,-0.0323402,0.043095898,0.099132724,0.041992452,0.051662184,-0.09777171,0.029935071,0.04370171,-0.023048244,-0.016570812,-0.06500467,-0.04898134,0.033587106,0.09255587,-0.004953528,0.054745104,0.025678245,-0.045797408,0.024257103,0.08443249,-0.019682819,0.024134412,-0.066396,0.053939085,0.012336098,0.072165065,0.01921177,-0.0803759,-0.021524638,-0.022970846,0.022605937,0.004872846,-0.009677307,0.016856994,0.018651705,-0.015817642,0.020847667,0.012602071,-0.023653273,-0.00041997258,-0.055073805,0.058815055,0.004231427,0.07764265,0.06860393,-0.01174842,-0.063983455,0.041742086,0.01268973,-0.008748085,-0.018600529,-0.01356024,-0.0067397025,-0.08329518,0.07560031,-0.09147725,1.8361982e-33,0.023606522,-0.011402674,0.015784279,0.027041946,-0.004689641,-0.04924287,-0.07544564,-0.09573005,-0.00818683,-0.09591185,-0.030142998,-0.083670706,0.05583698,0.09274858,-0.008059522,-0.048851848,0.030971518,-0.046781547,0.022194883,-0.010297356,0.022510462,0.018708952,-0.026295003,-0.012152224,0.019075362,0.04380764,-0.06120509,0.012817113,-0.048531562,0.011570562,-0.07666822,0.035894815,-0.044702824,0.0820632,0.06498147,0.040727306,-0.024988305,-0.06922529,0.064929314,0.0003174398,0.029837618,0.004591467,-0.06737416,0.016456911,0.038880114,0.03009962,0.06722285,0.0018941511,-0.038709033,0.004847477,0.031947453,-0.036152266,-0.02826659,-0.13091183,-0.0072132894,-0.059970986,0.0126592135,-0.016528407,-0.038603947,0.06225364,-0.02792984,-0.006155784,-0.04193189,0.088205524,0.014181598,0.072856784,-0.09534854,-0.0893344,-0.067428485,0.011379252,-0.005199112,0.013949958,0.024815906,-0.008019208,0.050229754,-0.04672583,-0.06179898,0.049396425,-0.055313874,0.024524413,-0.03856754,-0.019312086,-0.105898224,0.07475634,-0.031234253,-0.047939472,0.052312806,0.009937713,0.038552944,-0.009818516,0.04419822,0.009352809,0.038507387,0.104753606,-0.052625917,-2.9210572e-33,0.03317974,-0.055298157,0.058637206,0.0022615388,-0.013546661,0.1247735,0.054468494,-0.0617473,0.099363305,0.017474487,0.10050936,-0.0073309094,-0.021271773,-0.04418706,0.020819293,0.038507402,-0.063459314,0.051571887,0.033637755,-0.07001831,-0.026420293,0.00621616,0.034483753,0.06831911,0.046079747,0.052766807,-0.029669369,0.011630522,-0.0044264602,0.0074754455,-0.124489285,0.040926687,-0.026373615,-0.058786448,0.013168538,-0.043112658,0.010265658,-0.04389725,-0.012679543,-0.07272832,0.080133885,0.10671975,0.008719559,0.08145786,-0.009818426,0.06575334,0.07017212,-0.0035207274,-0.1307221,-0.049626525,0.024685517,-0.060291875,0.021032339,0.004562032,-0.048572008,0.05673744,0.07833552,0.0552814,0.043136932,0.061070327,-0.056700796,-0.017265998,-0.002896585,-0.023718022,0.07451214,-0.03593353,-0.031161923,0.0043111257,-0.013685875,0.05074472,0.10119387,0.002658285,0.09427696,0.057519596,0.026185295,0.04775974,-0.007215837,0.0051427726,0.04088938,-0.12174897,-0.07582223,0.061388057,-0.013813967,-0.054938275,0.04195428,0.04183892,0.0049626543,-0.010103739,0.0064315363,0.02987309,0.0019902217,-0.03875062,-0.048297863,0.07301804,-0.0037328147,-4.570318e-08,0.049451165,-0.012749127,-0.044465877,-0.056039654,0.023676606,0.060136598,0.06149287,0.048499923,0.04803582,0.046824843,0.010478176,0.017660124,0.039108656,-0.04918569,-0.045452707,0.0961864,-0.022234457,0.013694999,-0.022482496,-0.024852602,-0.0041549606,-0.049262647,-0.025571236,0.048344932,0.039087273,-0.038682338,0.043703508,0.110093765,-0.040830925,-0.064457424,0.03286155,-0.05187272,-0.033991724,-0.041575428,-0.07004042,0.035675675,-0.006729173,-0.09371763,-0.0045605088,0.043997854,-0.007826383,0.042316288,-0.029624792,-0.04322928,-0.0023584352,-0.0023296739,0.033463843,-0.07690367,-0.021367364,0.01908634,0.016349247,-0.05867566,0.05232589,-0.08058498,-0.11036686,-0.017460687,0.0049850936,0.011935661,-0.00077549875,-0.08638947,0.04176626,0.010966225,0.14165613,0.005166688 +2.7.1.124,"Activates EC 1.14.16.2 tyrosine 3-monooxygenase, by phosphorylation. Specific for this substrate, with which it co-purifies. See comment on EC 2.7.1.37 protein kinase.",384,1.0,-0.06461032,0.027840475,-0.09300732,-0.033510722,0.082692176,-0.012166862,0.044046182,0.022513624,0.06521652,0.013028072,0.043826587,-0.10285457,-0.033707958,0.056005225,0.011559128,0.044150785,-0.037209816,-0.016863214,0.034423705,-0.1124923,0.012955603,0.0075807534,0.024158673,0.010978493,-0.031504877,0.0049444307,0.0141179515,-0.004880428,-0.023386477,-0.04756695,-0.007728778,-0.012521141,0.101495594,-0.01708717,-0.052888267,0.117241874,-0.05189848,-0.1361221,0.011921341,0.037129417,0.029854365,-0.05003719,-0.022424763,-0.052170724,-0.059769113,-0.016453736,0.055315565,0.010576852,0.039868098,-0.022913467,0.0059659723,-0.04443224,0.048301913,0.015978415,0.0036387723,0.0352842,-0.095040835,0.030624988,-0.022364276,0.008909499,-0.0178348,-0.021802936,0.044872507,0.061719086,0.016606681,-0.029994467,0.03627909,-0.08538531,-0.037380517,-0.042851266,-0.017469672,-0.062097788,0.00376333,-0.037383746,-0.036765646,0.078009166,0.0033040694,-0.07028061,0.068456955,-0.043855254,-0.018132169,-0.017790932,0.030129645,0.05488373,-0.018302977,-0.009604469,-0.04060007,-0.025431432,-0.05812022,0.09296882,0.06682213,-0.08041236,0.024180794,0.04790127,0.004478627,0.017734893,0.040538177,0.049419716,-0.00020139894,0.004503916,-0.037688576,0.14296418,-0.050246295,0.023037743,-0.01529466,-0.00045923688,0.009255411,0.051576417,-0.01198271,-0.030001972,0.00365951,-0.08242891,0.11648316,0.017151302,0.010438873,0.13750409,0.03633606,-0.07410813,0.035337854,0.026185136,0.037513234,-0.06060835,-0.013957688,0.0075939875,-0.027573153,0.089611076,-0.015239454,-1.4885748e-35,0.06585011,0.05292274,0.02362772,-0.00757987,-0.021377806,-0.0037178043,-0.01740878,-0.027523842,-0.035198923,-0.04825978,-0.050089788,0.0023921486,0.081130095,0.049581423,-0.080096625,-0.0856463,-0.06864637,-0.003100662,-0.015248199,0.030455327,0.028853903,0.01062575,-0.050202847,-0.012877771,-0.014306015,0.0646122,-0.0686263,0.014628131,0.009296912,0.031581342,-0.014270403,0.0031020988,-0.0963764,0.029823434,-0.041618068,-0.009839954,-0.023896603,-0.046722885,-0.030401098,0.034984563,0.027947316,0.00376678,-0.04482925,-0.066648535,0.057081603,-0.058192994,-0.058808472,0.15265797,0.08292879,0.065599605,0.090761475,-0.04565551,0.04376985,-0.079890534,0.037701853,0.034703687,-0.08936863,-0.020219231,0.07512378,0.041708358,-0.008603839,-0.0024806056,-0.023300868,0.06378149,0.048543327,0.07493884,-0.077676535,-0.110555016,-0.06635998,0.05799504,-0.006094669,0.036225762,0.05144398,0.0017697896,-0.031777713,0.021380907,-0.060134135,-0.02530217,-0.031422768,0.03635518,-0.015080439,-0.029620241,0.03426574,0.01095071,0.0068658134,0.006838125,0.014599851,-0.0747249,-0.034807067,0.020193925,0.03410017,-0.028683785,-0.08413093,0.03456014,-0.04288521,-2.4490606e-33,0.08814338,-0.042264417,-0.05510297,-0.114724725,-0.04686862,0.13270845,0.016342593,-0.020437242,0.025841882,0.011658574,0.09343235,0.010507187,0.021750823,-0.09469809,0.010697858,-0.09076437,-0.015465075,0.047524437,-0.07404075,0.00029850894,0.04953128,-0.008134315,-0.040178083,0.11244177,0.07174503,-0.03371472,-0.10046056,0.06219966,-0.02855085,0.051761486,-0.06318277,0.00639885,-0.0065531908,0.07199114,0.09030443,0.056096394,-0.054257303,-0.00207836,0.04816075,-0.054618385,-0.027947513,0.012355289,0.032120675,0.04599216,0.014523012,0.13381048,-0.07921426,0.013391944,0.00031362503,-0.02516739,-0.081510074,0.00047224428,0.016562004,0.06299967,-0.007311682,0.06387253,-0.030307477,0.013936757,0.015412488,-0.0041402914,-0.0090580685,-0.033423383,0.03577509,0.0320434,0.023273733,-0.05524525,-0.113197304,0.027153196,0.052173268,0.04583887,0.04191378,0.026791455,0.04090808,-0.037436917,-0.041808758,-0.03855808,-0.07356432,-0.04548845,0.0034059605,-0.097238466,-0.0072592986,0.06645946,0.013245648,-0.052895408,-0.019131027,-0.019120017,0.012368371,0.014329638,-0.016861957,-0.0076324493,-0.047588542,-0.03749144,-0.17202872,0.009944026,0.025296116,-3.8131862e-08,0.0120790955,-0.006201267,0.06089772,-0.01294039,0.0040238257,0.1054918,0.027671486,0.030154513,0.006036539,-0.057758346,0.06634091,0.012704337,0.091708824,-0.046061967,0.0969686,-0.0097268615,0.0132325385,0.052381076,-0.011392608,-0.091083944,0.00014997716,-0.0710496,0.0062931185,0.005337277,0.03716179,-0.033587616,0.0072967364,0.08349395,0.0184736,-0.054809313,-0.010640072,-0.017082652,0.0148599,-0.014844725,-0.033111326,0.073953256,-0.089244775,-0.011019978,-0.065644465,0.0043712775,-0.043136366,-0.003654822,-0.064775296,-0.03911671,-0.031154104,0.05152465,0.041005403,0.027699893,-0.05492144,-0.01235773,0.053148463,-0.030346576,0.03424674,0.01579716,-0.07523476,0.010830154,-0.045116436,-0.03673956,0.00069719943,-0.059934974,0.039936837,0.06781588,0.117022455,-0.012575473 +2.7.1.125,"Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.1.126 [beta-adrenergic-receptor] kinase).",384,0.99999994,-0.08344226,0.010402409,-0.060937706,0.054109577,0.075932905,0.07406325,-0.01913873,0.036773317,0.0052557453,-0.013048138,-0.0030582175,0.02906803,-0.02527068,0.13032682,-0.048275605,0.04350532,-0.032662656,0.044154245,0.031351745,0.010593692,0.0076657753,0.035899915,0.040872097,-0.021357426,-0.019856533,0.011402491,0.050898828,0.021715557,-0.036604144,0.026081327,-0.03351911,-0.04343952,0.06615531,0.014099668,-0.023590103,0.07166298,-0.012325985,-0.05191521,-0.021986028,0.046744663,0.07845373,-0.0059094583,-0.006296482,-0.00672746,0.06678485,0.045182835,-0.06199069,0.053894486,-0.05177398,0.03413265,-0.010549912,-0.029113805,0.039205533,0.15677173,0.009864907,0.086782254,-0.10350075,0.03221194,-0.008033023,-0.031597894,-0.020622019,-0.028291726,0.010851243,0.022347929,0.054492246,0.027000891,-0.004902782,-0.05935611,0.0066964026,-0.041966964,0.072782636,0.014891949,0.020575901,-0.032838076,-0.019960288,0.030306358,-0.038299106,-0.050665043,-0.023769453,-0.07474313,0.10010812,-0.01252518,0.04279765,0.042720612,-0.0122953635,0.031136813,-0.0040875063,-0.06635748,-0.06775244,0.077307545,0.0632582,-0.028253213,-0.04238737,-0.045163833,-0.123944566,-0.061014306,-0.022723325,0.07720581,-0.084001325,0.020921146,0.012921157,0.025546929,-0.03431244,-0.06851023,0.017945942,0.05622305,0.004334591,-0.036742274,-0.020118125,0.01846146,0.02463554,-0.025445802,0.043932386,0.0022571671,0.035850532,0.08676054,-0.027511012,0.017194547,-0.04274309,0.04019086,0.032265503,-0.043937553,-0.09150812,0.012441804,-0.056827337,0.054383256,-0.11667784,2.460258e-33,0.010167906,-0.026214613,-0.018168207,-0.04745999,0.060938995,0.020418601,-0.053179946,0.0088378675,0.064562865,-0.10464065,-0.026381025,-0.04817078,0.04400574,0.07218218,-0.033442944,-0.05577231,0.021484364,-0.012732773,0.08431265,-0.04347767,0.057836644,0.018567422,-0.0960639,-0.015156395,0.010005403,0.020040436,-0.07706368,0.025313113,0.020448437,-0.01040203,0.07205756,0.029145965,-0.058435164,0.05070342,-0.00021597734,0.04488399,-0.028994072,-0.061589744,0.017996265,-0.04889154,0.017464396,-0.003105767,-0.11624069,0.05161464,0.024530143,-0.0638483,-0.07380327,-0.024994431,0.0045160768,0.021063752,0.108442515,-0.023197874,-0.0044323546,-0.022032559,-0.024353337,0.0025412776,-0.03682626,-0.12409312,-0.0011410237,0.022391794,0.040938817,0.0044462397,-0.008320029,0.019116031,-0.018542562,0.05327854,-0.02126138,-0.17952672,-0.10957036,-0.059214573,-0.029983193,0.047426235,0.113734886,-0.007406727,-0.027370917,-0.034961134,0.012369265,0.027675742,-0.052300956,0.00852796,-0.032711986,-0.052374277,0.002540722,0.067122884,-0.01347575,-0.033959806,0.0877322,-0.06394045,-0.005474589,-0.054088376,0.050811615,-0.0945356,-0.09151844,0.028391697,0.020101402,-3.8898078e-33,0.023936143,-0.028839236,0.026891908,0.0051715197,-0.03317617,0.02689022,-0.02976561,-0.05272058,0.020469254,-0.09570988,0.032234427,-0.016896041,0.010128749,0.015875565,0.054688495,0.002718574,-0.004239705,0.060349938,-0.033370208,-0.0177287,-0.01103347,0.0020783462,0.006539677,0.12048176,0.028543595,-0.039470147,0.029457834,-0.0016138477,0.07316389,0.07597884,-0.08387742,0.036241595,-0.09954507,-0.07962458,-0.01657044,0.06791469,-0.02595552,-0.0025100473,-0.0204765,-0.02481539,0.06249252,-0.012266765,-0.044119682,0.055332568,0.019294884,0.09385054,0.014386914,0.0514259,-0.069953695,-0.05451914,0.018612452,0.046753578,-0.009469371,0.07335118,0.062086854,0.082262725,-0.04203173,-0.0017740526,-0.006842625,-0.024397694,-0.02751167,0.002119312,-0.0009660135,0.0137490975,0.037418783,0.014141607,0.06511746,0.046753645,0.1060518,-0.030084293,0.09517436,0.056877412,0.11661913,0.06571265,-0.09079257,-0.07025744,-0.061019436,-0.0188205,-0.042619128,-0.053103127,-0.017628593,-0.0046643238,0.024043217,-0.013276977,-0.06060157,0.035815883,0.035019338,0.048071444,-0.08279816,-0.014980734,0.032797277,0.06590205,-0.012660385,0.0065529514,0.0022975323,-4.0857977e-08,0.09150864,-0.06253215,0.103625104,-0.098220505,-0.009848645,-0.02682733,0.1252899,0.017637635,-0.025027055,0.016745009,-0.023088245,0.055758175,0.024659136,-0.09720485,0.0041851103,0.02536438,0.008842446,0.039815675,-0.040694013,0.012699946,-0.039595503,-0.0074758157,-0.040542707,-0.00686721,0.020851882,-0.052529823,0.0332009,0.03929835,-0.045946382,-0.023765467,0.12622409,0.0131727075,0.031980854,-0.03782404,-0.04122126,-0.0014661523,0.05451784,-0.055613894,-0.01871943,-0.029851036,-0.0854263,-0.0046372674,0.034216907,0.036176994,-0.05664944,-0.10457057,0.12675583,-0.073023215,0.08584797,-0.012019063,-0.018936902,0.046610434,-0.071568094,-0.07067066,-0.061662313,-0.0063569974,0.00094707764,0.014768817,-0.0048935656,0.020877881,0.0271604,-0.008513305,0.06409526,0.012713942 +2.7.1.126,"Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. Inhibited by Zn2+ and digitonin; unaffected by cyclic-AMP (cf. EC 2.7.1.125 rhodopsin kinase). See comment on EC 2.7.1.37 protein kinase.",384,1.0,-0.055934336,0.017565783,-0.048622146,0.015560212,0.039401878,0.044516895,-0.040545233,0.03403985,0.006645309,-0.004618571,0.015354781,0.01325661,0.046094783,0.10400128,-0.013398277,0.029459208,0.015441738,0.015423255,0.010785032,-0.0038678723,-0.011898822,0.03706282,0.023566866,-0.034680437,-0.037521407,-0.010248892,0.05580356,0.04974212,-0.022721509,-0.01490575,-0.091476984,-0.024418449,0.039050292,0.0028888416,-0.03317435,0.108544976,-0.014609245,-0.011086604,-0.0082501285,0.028723175,0.07025886,-0.015273852,0.014206734,-0.031665206,0.0148958005,0.019370837,-0.04134461,0.0212058,-0.08540843,0.03389592,-0.013889849,-0.04190796,0.034318823,0.15622151,-0.0029378452,0.050590597,-0.09853142,0.058952395,-0.023842914,-0.07012079,-0.012938531,-0.078891866,0.039784692,0.020980448,0.044650894,0.0163716,0.014247693,-0.0909516,0.015901325,-0.07220892,0.062767066,-0.026848778,0.059667476,-0.016815096,-0.0017184905,-0.0030492751,-0.043487884,-0.06161617,0.027767517,-0.11605684,0.07000473,0.014413183,0.0389866,0.020885255,-0.0008284165,0.0375448,0.011644797,-0.03085497,-0.116812035,0.053435158,0.07212954,-0.053843442,-0.020141203,-0.041312136,-0.13201737,-0.046775404,-0.018470041,0.0963154,-0.076434836,0.02462191,0.08112941,0.06798088,-0.0660367,-0.07154043,-0.0029866823,0.055955,0.015477318,-0.026614372,-0.083282344,0.019331831,0.02279596,-0.030995883,0.023106163,-0.010505368,0.012451769,0.10070387,0.022092134,0.04209384,-0.013362726,0.029881647,0.03178316,-0.08219914,-0.05967771,0.053699214,-0.04754316,0.07138208,-0.102946766,2.872071e-33,-0.024561943,-0.055250026,-0.03195899,-0.06540218,0.021043953,-0.0068339757,-0.0441161,0.063314274,0.05418934,-0.13608043,-0.009120952,-0.03162748,0.08201108,0.016552635,-0.09400013,-0.056795105,-0.022559458,-0.052934907,0.054155424,-0.06047652,0.052523453,0.011275332,-0.081473924,0.040865883,0.010168822,0.049959905,-0.053928107,0.011083279,-0.012021475,0.0052712536,0.032459546,0.020646216,-0.07561862,0.06482564,0.04319113,0.039390482,0.01424505,-0.032830153,0.035296615,-0.033453174,-0.005165139,-0.015497444,-0.07812238,-0.011142568,0.010221508,-0.0707046,-0.06424104,0.024415193,0.010683678,-0.017121984,0.12702033,-0.060314946,0.019784791,-0.0069638863,-0.04560534,-0.013246311,-0.034749832,-0.11492433,-0.014546168,0.050917316,0.058317527,0.028831385,0.041189346,0.026169352,-0.05406716,0.0685101,-0.072842754,-0.16215542,-0.061421487,0.0004361258,-0.013415012,0.044734698,0.10288809,0.01692007,-0.023166139,-0.00941304,0.03035088,0.020087387,-0.013976849,0.10264999,-0.010992159,-0.055582255,-0.0013258711,0.031101057,-0.0166347,-0.06388688,0.06306547,-0.10831055,-0.009276097,-0.04612665,0.03464355,-0.052373365,-0.0633427,0.05572569,0.020741247,-5.1599166e-33,0.041607607,0.016719803,0.0449999,0.02578136,-0.016705936,0.011858494,-0.020032465,-0.045019735,0.018011099,-0.09775189,0.077860825,-0.0070672454,0.050413363,0.069516934,0.08344662,0.0007523379,-0.02747397,0.02592413,-0.010927347,-0.007847233,-0.04875062,-0.08192306,-0.0066822413,0.1276845,0.05220755,0.0029476625,-0.016222022,-0.015455193,0.053261925,0.09743072,-0.060658026,-0.013293791,-0.10856999,-0.0439598,-0.0064898003,0.054611627,-0.026166344,0.015963329,-0.045109734,-0.038475405,0.033750616,-0.018046575,-0.0053293784,0.10047441,0.009222306,0.0617927,0.062486768,0.07308067,-0.07991332,-0.04128832,0.02873701,0.07127697,-0.013429983,0.048188485,0.03312507,0.12296535,0.035850193,0.029150886,-0.029376527,-0.016929006,-0.09643704,-0.007885499,0.003513943,0.017748976,0.027647683,0.0046257135,0.023098819,0.013417374,0.09766491,0.002497781,0.094748646,0.043536086,0.056086462,-0.0101544475,-0.10270758,-0.0031373508,0.0057346034,-0.03215673,-0.06236573,-0.06264519,-0.016077092,-0.013430892,0.011958685,-0.031265903,-0.075936936,0.03299563,0.010565408,0.0014972036,-0.07012915,0.0135185225,0.019686725,0.05816789,-0.048123416,-0.006204172,-0.0038804829,-4.3997694e-08,0.07779439,-0.06614422,0.10507525,-0.076595224,0.051647164,-0.00609422,0.08273266,-0.022569485,-0.016496513,0.05299881,-0.0011994176,0.0464174,0.027388701,-0.07509229,0.012463268,0.040772036,0.0015738135,0.05491088,-0.03796404,0.009540088,-0.039284278,-0.060432322,-0.06339582,0.009929209,-0.0046901316,-0.028601134,0.010150231,0.026353456,-0.022102887,-0.06498355,0.11419011,0.010810451,0.028314294,-0.038415268,-0.045569506,0.0025165325,0.053481705,-0.04008144,-0.0704533,-0.02670747,-0.052040774,0.015626082,0.007719894,0.021443143,-0.057461116,-0.10151274,0.10362117,-0.0659276,0.036469348,0.018622786,-0.026682943,0.02554693,-0.043912176,-0.07505198,-0.028312443,-0.0038853807,0.0068848818,-0.020380137,0.008329351,0.031956244,-0.04249008,0.01547337,0.07969237,-0.028465297 +2.7.1.127,Activated by Ca2+. Three isoforms have been shown to exist [3].,384,1.0,-0.08748993,-0.06571229,-0.043558836,0.007328824,-0.011407022,0.024346799,0.04152658,0.009251616,0.09289535,-0.007430983,0.10517728,-0.09532153,0.002370912,0.04729839,0.012406163,-0.017259132,-0.1078987,0.021494856,-0.0039028053,-0.042230032,0.09990584,-0.0027816887,-0.036104918,0.017390734,0.027597915,0.05034033,-0.023253895,0.0010931427,0.07712925,-0.056808256,-0.06225232,0.034163415,0.07739858,-0.08322217,0.031839065,-0.012153877,-0.069762014,-0.017971413,-0.05749368,-0.028089384,0.048105042,-0.046914674,0.030461222,0.041609026,-0.021412037,0.014110453,-0.0006337692,-0.046418596,0.010835607,-0.01124017,-0.0042411,-0.030091835,-0.017258324,0.118621044,-0.042082075,-0.062146958,-0.075389355,0.07378887,0.0439045,-0.037729148,0.019999793,-0.008814196,0.030990813,-0.0027911041,0.050772015,0.08204126,-0.046053264,-0.12143543,0.050234728,0.0130942,-0.031584363,-0.011326089,0.0030056653,-0.02180591,0.041118015,0.0051898025,-0.045361694,-0.021534862,0.029749308,-0.031998806,0.035524897,0.016491799,0.030643772,0.08610541,-0.016580602,0.060815006,-0.051451582,0.004149109,-0.041808236,-0.027761886,0.06638205,0.06076435,0.03184892,0.003065652,-7.1356e-05,0.038505968,0.01970321,-0.011719099,0.032276448,-0.027562052,0.084806204,0.019869993,-0.122085735,-0.08524299,0.011414573,0.010832932,-0.027960246,-0.006603298,-0.054441042,0.061881006,0.031443402,-0.050201423,0.008280496,-0.03822862,-0.026271598,0.16413869,0.0049104155,-0.00718114,-0.006910327,-0.045730602,-0.010569725,-0.07558116,-0.057843655,-0.07686737,-0.049910046,-0.04818068,-0.058796704,-1.9578646e-33,0.045397013,0.07190049,-0.0017129189,0.08910094,0.013117587,-0.020973006,-0.014638851,-0.0568239,-0.020348225,-0.06368675,-0.041498885,-0.011954516,-0.030181156,0.08577586,-0.025015108,-0.026179627,-0.022753356,-0.027891703,0.093402706,-0.05191538,0.072521396,0.10360341,-0.02394244,-0.038659036,0.028723678,0.10273331,-0.03183534,0.024614407,-0.0012458957,-0.008951012,0.057694852,0.004294273,-0.12026714,0.01844103,0.041260377,0.056204885,0.013625059,0.006947711,-0.00887495,0.068405524,0.08687634,0.01584215,0.026961021,-0.04379839,0.118644856,-0.029742973,-0.038286198,0.059271947,0.10845865,0.07338182,0.016906783,0.0023362054,0.013958985,-0.06837102,-0.02773064,0.0027079682,-0.05529019,-0.026713002,-0.0981963,0.0052185003,0.012147089,0.027117295,0.027005745,0.056992617,-0.063486576,0.06504955,-0.11602533,-0.04346192,0.0050359005,0.057299875,-0.07612595,-0.011398495,0.015016765,-0.029589014,0.04031091,-0.013504831,-0.086166784,0.027442275,-0.017230364,0.044505738,-0.092677295,-0.033190183,-0.030338127,0.047866784,-0.034380168,0.001220123,-0.009055339,-0.039632466,-0.044315502,0.0521418,0.050647818,-0.013355605,-0.031716794,0.04664729,-0.062494747,-5.679426e-34,0.0070423936,-0.045383766,0.022814387,-0.068848275,-0.05430708,0.051848065,-0.000671254,-0.024548704,0.01606685,0.022868425,0.08889238,0.07286964,0.007218454,-0.042958964,-0.014550763,0.022665113,0.0067700376,0.08230291,-0.0032505237,-0.03358303,0.019875236,0.02167649,-0.045002833,0.08049032,0.02532644,0.043354604,0.09517379,-0.012987713,0.11710822,0.061001863,-0.07653588,0.016099961,-0.0556129,0.027364578,-0.054556128,-0.035169326,0.04301449,0.0055165673,-0.088344686,-0.022452928,-0.033789616,-0.020650022,0.002564367,0.10958347,0.017209062,0.007872723,0.119812,0.05083579,-0.09982454,0.009219739,0.024860192,-0.115152806,-0.059182044,0.016619578,0.0021815754,0.11655019,-0.019859148,0.044557594,0.03230629,0.03243347,0.0048739226,0.023339137,-0.002592318,-0.113362245,0.067475565,0.027563289,-0.010678974,0.042034496,-0.013545705,-0.050385464,0.10667856,-0.0142069375,-0.0033598242,-0.070826605,-0.024810782,-0.06776022,-0.046614055,-0.04439973,-0.052526344,-0.048051946,-0.016864303,0.00181391,0.04206405,-0.0030044117,0.025482727,0.0039297156,-0.028456252,0.05821428,0.0074682017,0.04385995,-0.0678038,0.06625984,-0.039810415,0.10176353,0.07485329,-2.4035375e-08,0.010356736,0.011243427,-0.025742568,-0.11692845,-0.04591587,0.034347992,0.027013319,0.082374215,-0.030530864,-0.05138013,-0.0047052996,0.009144665,0.003951154,0.008815137,0.072657086,0.038344495,-0.03574267,0.062055282,-0.04775658,-0.07632859,-0.0844154,-0.055587523,-0.028104156,-0.0121694775,-0.032228235,0.020575725,0.031402107,0.04439057,-0.0044436585,0.0061088805,0.051779162,-0.014411284,0.04623644,-0.08057781,-0.017238839,0.03919907,-0.035420027,-0.06690428,-0.03694283,-0.0029767742,-0.022324769,-0.023894358,-0.06971154,0.047085382,0.013397423,0.02796932,-0.03974125,0.037579782,-0.026342642,-0.018330552,-0.024653254,-0.0479847,-0.024859173,-0.04394203,-0.15006241,0.022012841,-0.005330157,0.026364932,0.054513834,-0.01986711,0.09810719,-0.009914011,0.098869435,-0.01905854 +2.7.1.128,Phosphorylates and inactivates EC 6.4.1.2 acetyl-CoA carboxylase. See comment on EC 2.7.1.37 protein kinase.,384,1.0,-0.050850507,-0.014532469,-0.044811573,0.06370893,0.07093557,0.08736566,-0.06897822,-0.025241962,0.053942714,-0.03488756,0.04529014,-0.050158672,-0.07892282,-0.021460388,-0.028263403,-0.002421386,-0.08239014,0.04252471,-0.04140229,-0.031499524,-0.03982997,0.016456494,-0.025600411,0.052639842,0.027485402,-0.07208783,0.06952389,0.030018257,-0.03384705,-0.107249156,-0.009017191,-0.029720673,0.043359566,0.03439239,0.008101122,0.09209527,9.042869e-06,-0.15411311,0.004687732,0.0071036573,0.05162253,-0.027948385,-0.0017219571,-0.054109633,-0.027724233,0.014881227,0.007241773,-0.017135581,0.07527611,-0.04392117,0.04684543,-0.008627151,-0.024708293,0.03240107,-0.03971749,0.033159375,-0.106360905,0.028874973,0.012295962,0.032662746,0.021612661,-0.0053476514,0.07603354,0.047137145,0.007850594,-0.025671214,0.072700165,-0.024853025,0.004715174,0.047845453,-0.07816853,-0.045650166,0.06561196,0.057607666,0.03512921,0.009510205,-0.075476006,-0.11839223,0.074129045,-0.012899001,0.005318067,-0.029421434,-0.027030481,0.013220584,-0.0430121,-0.011125146,0.01614025,-0.023183621,-0.051633634,-0.0031346246,0.07404902,-0.08028217,0.06370658,-0.036459316,-0.058941066,0.0223995,0.043148737,0.025136389,-0.021646312,-0.03798309,-0.0014791307,0.11421877,-0.061815962,-0.014241644,0.06963041,-0.01882334,0.021523593,0.08918102,-0.011261557,0.0428851,0.0073259184,-0.08093878,0.061751973,-0.012206037,-0.009696663,0.13112871,-0.06886089,-0.048288062,0.015572165,0.049718104,0.07272572,-0.047103986,0.021532938,0.051025875,-0.054678883,0.039993193,-0.03793868,1.3646719e-33,0.022087168,-0.019312425,0.15513271,0.021617781,0.028151082,-0.07707275,-0.05735126,-0.01576234,0.0028199137,-0.087660685,-0.0025913627,0.0030532524,0.06283713,-0.0011720961,-0.014865574,-0.04416159,-0.07876397,-0.02486018,0.040337235,0.026251784,0.020306813,-0.0037178616,-0.027815716,0.05858597,0.021227494,0.04374602,-0.045007594,0.043974623,0.025398152,0.05541901,-0.0623397,0.027367644,-0.034302056,0.050507136,-0.043426424,-0.059528507,-0.035487175,-0.04842276,0.03029513,0.050719555,0.111755066,-0.019544069,-0.042467516,-0.06615119,-0.0010295006,-0.08515241,0.014047618,0.107737616,0.04472344,0.020246528,0.03932673,-0.06865784,0.06778604,-0.024968745,0.034958854,-0.010722123,-0.13905168,-0.02660256,0.0037297793,0.045314576,0.02014375,0.08856935,-0.002144034,0.05381552,-0.04021327,0.042038072,-0.15918835,-0.11488853,-0.078886025,0.029247902,0.0031464323,-0.009893896,0.080839954,0.036327057,0.003749853,0.014344658,-0.012117546,0.040609658,-0.057379022,0.08163545,-0.004180247,0.008174031,0.031456336,0.04742035,0.011121839,-0.06473007,0.045129355,-0.002511005,-0.019826835,0.054157753,0.014368707,-0.055502784,-0.012769091,0.085391566,-0.037968908,-3.4996458e-33,0.119515985,-0.027804008,0.03030395,-0.05125335,-0.02351774,0.091325566,0.06978172,-0.008270175,0.038889885,-0.00066556985,0.07292735,0.019012235,0.0028743008,-0.042847577,0.091454014,-0.035367846,-0.029200926,0.004698671,-0.026196769,0.042511705,-0.022845726,-0.039388105,-0.0062373835,0.063003615,0.06723216,-0.036333725,-0.06609883,0.0028801146,-0.027240679,0.016937314,-0.022386588,0.013107123,-0.03951992,0.01386396,-0.06050399,-0.017608287,-0.027131492,0.010830257,-0.049785666,-0.010043156,-0.04370811,0.029500589,-0.027746499,-0.016833996,0.091753475,0.031403605,0.029613575,0.06056362,-0.029332954,-0.05885499,-0.015249215,-0.0068097175,-0.047973763,0.04621628,-0.041348968,0.088388294,-0.011099528,0.07279563,0.06961285,-0.010484384,-0.048418738,-0.042485133,-0.0028760321,-0.019569641,0.067924686,-0.021072738,-0.04890636,0.060836833,0.036552656,-0.03502701,0.07712882,0.059524167,0.039617013,-0.0008622178,-0.006410203,0.008463081,-0.092644036,-0.08753554,0.0021345473,-0.07334016,-0.09044944,0.028642504,-0.03757652,-0.029277181,-0.06462754,0.0114763845,0.029289242,0.022875123,-0.025346966,0.04191878,-0.08269319,-0.08754901,-0.09516747,0.06348202,-0.04479723,-3.204581e-08,0.085287265,-0.016839575,0.039674964,-0.06887211,0.0662333,0.048417814,0.040885758,0.09000867,0.013193349,-0.032100234,0.018511862,0.026408864,0.09926758,-0.021607194,-0.0033997537,0.007440009,-0.014404305,0.057152305,-0.014018564,-0.004101876,0.010306858,-0.07869604,-0.012216856,0.06185282,-0.00626409,-0.021015499,0.08447357,0.08301038,-0.058665846,-0.06750159,0.0077188024,-0.029883992,0.00027373768,0.014538436,-0.004630809,0.01442647,-0.036829982,-0.031853054,-0.092764825,0.124828316,0.003390375,-0.058337312,-0.022138372,-0.008576026,0.006094551,-0.0057881665,0.048659287,0.0052263397,-0.008759035,-0.045616947,-0.010671535,-0.004131002,-0.12074117,-0.03596857,-0.0118777035,-0.071861014,-0.029645765,-0.06252704,0.021483429,-0.046101574,0.023442402,0.0711979,0.10335085,0.014455966 +2.7.1.129,"The enzyme from Dictyostelium sp. brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. One threonine residue in each heavy chain acts as acceptor.",384,0.99999994,-0.08688901,-0.02405186,-0.009886481,-0.014689712,0.028862499,-0.074382916,0.043103512,0.0797888,0.029281156,0.019248921,0.028058916,0.031144487,-0.028041895,0.089732006,-0.029008906,0.014953452,-0.028135367,0.0763451,0.010794592,-0.043214798,0.07773434,0.040542554,-0.001274193,0.03577507,-0.00042126045,-0.047583945,0.010683268,0.04266846,-0.029681101,-0.098341994,-0.08261007,-0.016391713,0.05509743,-0.0026150586,0.006776041,0.1427319,-0.058806606,-0.050815783,0.038655233,-0.10352773,0.13034171,0.038954068,0.02120844,0.014723201,-0.036055297,-0.019970145,-0.035778336,0.08486197,0.03306725,0.0849112,-0.07086689,-0.004447066,0.02884134,0.051447924,-0.028777607,-0.011937905,-0.021194346,0.04902129,0.009125804,-0.060751937,-0.022021638,-0.013684063,-0.014106311,0.04021733,-0.0071155843,-0.0037892165,-0.03196897,0.020594364,-0.023318464,-0.015968744,0.023135198,-0.015951388,-0.017353423,0.03172746,0.05453514,0.023478119,-0.10279629,0.0069569284,-0.025727486,-0.014039945,0.06548388,0.008120041,0.0729887,0.011043545,0.022144586,0.046618186,0.03756149,-0.029039364,0.026022796,-0.025635742,0.06528948,-0.042875092,-0.012481181,-0.0064573763,0.007647723,0.033145074,-0.018914804,0.009394214,-0.038701344,0.012811168,0.0771233,-0.027181584,-0.03582738,-0.009438309,-0.017481994,0.07553397,-0.023214415,-0.04045226,-0.017652877,0.06377638,0.00017196574,-0.0477077,0.055130318,0.012531473,-0.0067373924,0.0555299,0.032602873,-0.016686426,-0.041520283,-0.050796647,-0.010621573,-0.09706133,-0.022339806,0.010905688,-0.09897149,0.029816449,-0.11104006,5.3897518e-33,-0.022443336,-0.078302965,0.009002813,-0.019473894,0.04038407,-0.084607325,-0.040840525,-0.04451303,-0.07138577,-0.07816223,-0.05649344,-0.035968177,0.06652244,-0.0062414696,-0.090850644,-0.062983334,0.075170726,0.011663799,0.13393515,0.040402137,0.0005028961,-0.025962736,-0.072312854,-0.03834925,-0.01451601,0.05473937,-0.084041774,0.04214034,0.047688633,-0.030082563,0.03701727,-0.10981497,-0.07028535,0.06913084,-0.009201485,-0.039807077,-0.07907855,-0.08624639,0.017860722,-0.060156956,-0.10703244,-0.011876182,-0.015184574,-0.045858484,0.014894227,-0.008315889,0.009537339,0.016404012,-0.05711706,0.07503867,0.10639661,-0.06446603,0.056899652,-0.117954336,-0.07514885,0.02198213,0.04205216,0.011712893,0.020583099,0.07629434,0.013390648,0.030575886,-0.026888335,0.08574571,-0.048578486,0.02697218,-0.12154808,-0.062469143,0.033540875,0.07875284,-0.07864489,-0.020547384,-0.009827238,-0.05135526,0.04058073,0.005186589,-0.021314193,-0.022703601,-0.08183502,0.043336548,0.042966884,-0.04756103,-0.01973456,0.05751308,-0.029709114,0.018019488,-0.04122155,-0.037853632,0.017747758,0.012545993,0.070284374,-0.01688864,-0.060403273,0.12237323,0.047100857,-5.9805817e-33,0.08254912,-0.05581048,0.15892899,-0.031356838,-0.0717216,0.02802203,-0.034216084,-0.011646445,0.07793635,0.018912934,0.090997204,-0.06704131,-0.07121049,-0.0033511315,0.031154122,0.070703365,0.016299471,0.064473055,0.006165216,0.002352135,-0.060023643,0.10454251,-0.012571957,0.032876313,-0.043461554,-0.0397919,0.025839048,0.052552037,0.088042326,0.024892293,-0.080457196,0.010592165,-0.070553645,-0.018860236,0.010488017,-0.034522865,-0.016361896,-0.00044024258,0.034806564,-0.06763111,0.041631244,0.0712357,0.040354304,0.076030545,-0.005650609,0.03523124,-0.039824422,0.051055744,-0.07694328,-0.036093403,-0.02986982,0.018649256,0.04330238,0.06850683,0.07297721,0.06722864,0.11560947,0.03454744,-0.0033324137,-0.02689985,-0.040380888,-0.089403085,-0.027695794,0.03726345,0.07768033,0.014751235,-0.12378343,-0.00583819,-0.022677341,0.04216815,0.051733784,0.04806691,-0.019023841,0.039442915,-0.03943555,-0.005728228,-0.005969196,-0.054460026,0.02051782,0.0015031518,-0.028379291,0.03170616,-0.06483471,-0.084357396,0.015819363,-0.034782637,-0.006974898,0.08486491,-0.030931555,0.072193615,0.07708523,0.00010151354,-0.0012628061,0.0066154664,0.0010089271,-3.3807343e-08,0.012531366,-0.03585534,0.022923676,-0.06458412,-0.00935638,-0.007998465,0.09022622,0.054344222,0.038795974,0.04103763,0.018907545,0.014620776,0.030557105,-0.07435652,0.04794459,0.10070472,-0.03639861,0.023324382,-0.0034775701,-0.02219262,0.0663414,-0.06352077,-0.06601668,0.08528035,0.014304088,-0.038410045,0.07128704,0.020332463,-0.025471386,-0.010797397,-0.022635404,-0.008750055,-0.028545663,-0.08366791,-0.042058032,0.015006298,-0.06410677,-0.03788898,-0.021521818,0.0079578515,-0.016940836,-0.042687,0.0074895173,-0.014141353,-0.052259017,0.042201,-0.0011873704,-0.004590744,0.04461595,0.020765457,0.021334592,0.0035792682,0.0027095315,-0.020312786,-0.050107196,-0.00029033795,0.059443094,0.0069497987,-0.022893615,0.0068222303,0.059762202,0.036218073,0.14705504,-0.056785304 +2.7.1.130,"Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria.",384,1.0,-0.11467429,-0.031731993,-0.13538195,0.021546962,-0.058458544,0.033716,-0.03592882,0.033357315,0.080179706,-0.034250133,0.10265376,-0.06999678,-0.052005213,-0.026428508,-0.05970818,-0.015743528,-0.012616925,-0.0063557955,-0.06526245,-0.08509833,0.04072162,0.03705227,-0.0440656,-0.048011206,0.023366783,-0.046627536,-0.00037018742,-0.059637412,-0.010336862,-0.07711324,0.018168665,-0.089757755,0.0986819,-0.06133983,0.12242689,0.03567056,0.05600736,-0.018417822,0.13316162,0.021726534,0.009786649,-0.01128171,-0.0028149,0.02133157,0.00891916,-0.010289052,0.023479365,0.06692529,0.0562373,-0.033516623,0.012752318,0.027605817,-0.05343607,0.014905477,-0.021494638,0.051418558,-0.045642473,-0.028735388,-0.025661722,0.042396463,0.0005196804,0.015342866,0.09706043,0.031005086,-0.06564842,-0.0998148,0.098911256,-0.08982058,0.01928102,0.02007166,-0.09075799,-0.060114536,0.011740504,0.0036090077,0.062250935,0.04128968,-0.031202601,-0.037916403,0.01607886,-0.031161172,0.07067179,-0.07095599,-0.010405799,0.06241153,-0.025740633,-0.167301,0.054915037,-0.0057337456,0.021018367,0.07409558,-0.030850315,-0.07678679,0.086061805,0.017178103,-0.06508964,0.020226028,0.0732953,0.030894184,0.007184945,-0.04490225,-0.04343994,0.02639596,0.029741958,-0.025319954,-0.0013473658,-0.0001489044,0.009036538,0.070811436,-0.0051962943,-0.02797132,0.029961094,-0.011330902,0.019164464,-0.035816506,-0.019350698,0.050611075,-0.022394136,-0.05916896,-0.010781896,0.010886997,-0.048298452,-0.05276429,0.018242816,0.067057684,-0.03640074,0.07988842,-0.04557197,3.4541463e-34,0.06271739,0.031590294,0.01839713,-0.04971611,-0.016949082,-0.028803907,-0.10854485,-0.021888016,-0.030724362,-0.03134836,0.020412736,-0.1381606,0.042589758,0.08794155,0.024024433,0.044273034,-0.004094144,-0.01840482,0.03111319,0.022931647,-0.0477943,-0.0038996662,0.037470885,-0.072809115,0.12218361,0.025393812,-0.031416554,-0.030059893,0.04188163,0.015989877,-0.0008602882,-0.08880929,-0.041754987,0.052855358,0.041684795,-0.0012635057,-0.03033221,-0.04311543,0.008914052,-0.023969125,-0.018675514,0.09508026,-0.0054030106,-0.057599176,0.0012596683,0.043710425,-0.042183682,0.019570023,0.06708883,0.056365643,-0.0043959348,-0.013979253,0.10442422,0.05571329,0.014022582,-0.058996808,-0.07393894,0.019288762,0.01260171,0.022026138,0.020634724,0.110202156,-0.07726369,-0.025823088,-0.010106487,0.038851634,-0.06509489,-0.033555947,0.007340279,0.013843727,-0.040945657,-0.050965413,0.04981693,0.051428527,0.036867563,-0.031556908,-0.03544246,0.01982165,0.0006583531,0.009424394,-0.004450256,0.039544154,0.04808415,-0.06896669,-0.04028941,0.021544745,-0.057556055,0.00517933,0.05001394,0.029301744,-0.0015075648,0.0046262722,-0.06322327,0.09409237,-0.02776923,-2.7007978e-33,0.048377343,-0.07822549,-0.0049793734,-0.084535286,-0.0700892,0.055426635,-0.03726489,0.057109337,0.062021744,0.040854838,0.025693543,0.034709223,0.014880388,-0.055210706,0.05690134,-0.0751973,-0.009876889,0.04508643,-0.0001599648,0.0075641745,0.0067124,-0.013367262,0.010833122,0.02799294,0.028646274,-0.005163815,-0.06248697,0.056828577,-0.032009102,-0.001787217,0.008211113,0.027537525,-0.04975521,-0.021777224,-0.077181794,-0.04685112,-0.042752538,0.01735521,-0.009574174,0.019998752,0.03293676,0.06511367,0.05882704,0.010440196,0.056615565,0.08886845,-0.017309861,0.051512536,-0.0111611,-0.053221997,-0.040782057,-0.00037237647,0.05759176,0.051247023,0.035158787,0.06702522,0.06961423,0.060938,0.07237625,-0.09346697,-0.0630967,-0.09174133,0.044911716,-0.057436645,0.04270873,0.055290695,-0.014675715,0.042373702,0.048083104,0.015430739,0.032513663,0.044974413,-0.07735268,-0.00011456487,0.014366756,0.012264629,-0.09303222,-0.11785193,0.008758539,-0.029817171,-0.005817083,0.011139195,0.04233973,-0.054324593,0.029277505,0.021734193,0.038840927,0.06517432,-0.025111528,0.10045575,-0.010199887,-0.05916739,-0.0894403,0.021350954,0.017394416,-4.0686565e-08,0.041241724,0.011908301,0.04142809,-0.05917296,0.0006835675,0.042074934,0.01684009,0.041994788,0.04560838,-0.016322179,-0.024408001,0.084057994,0.0359286,-0.00035728852,-0.05858588,0.082476296,-0.046679314,0.015076116,0.02424343,0.015200564,-0.04420899,-0.041773967,-0.09892264,0.10235023,0.013975845,-0.067304954,0.06982468,-0.029999906,-0.052245557,-0.08660474,0.0011885432,0.014144174,-0.01913491,-0.02101201,0.0055628987,-0.078999445,-0.022695292,-0.09423201,-0.03746616,0.063870214,0.037821315,0.04432089,-0.054237664,0.0069226883,0.06884174,0.043613076,-0.0013018644,0.011092013,-0.12548497,-0.018896123,0.035565358,-0.056684807,-0.02189479,-0.058604844,-0.082355216,-0.064799786,-0.05761429,-0.0524022,-0.00060968834,0.042475305,0.012476041,0.03511782,0.13374768,0.01167747 +2.7.1.131,Phosphorylates the serine-833 in the cytoplasmic domain of the low-density lipoprotein receptor. GTP can act instead of ATP.,384,0.99999994,-0.06551056,0.013932464,-0.03891041,-0.026174998,0.006585581,0.0025103434,0.04352092,0.03548893,0.055924993,-0.022236126,-0.008111014,0.05053232,-0.024407478,0.056250706,0.07225856,-0.020612523,-0.013482703,0.012024102,-0.010323042,-0.025886185,0.06701272,0.037513096,0.016730605,0.029728832,-0.0907161,-0.025808504,0.04734422,-0.013932826,-0.08631423,0.06571901,-0.056848228,0.026241863,0.018513536,0.016102126,-0.006314852,0.053275034,0.026508698,-0.011864741,-0.06498043,-0.041670144,0.06667722,0.017064817,-0.064618014,0.06385613,0.029760068,-0.005502813,0.031455,0.018950494,0.03447089,-0.00439137,-0.021291673,-0.032992367,-0.033111125,-0.013997667,-0.03230314,0.0631986,-0.105417185,-0.049543582,0.044062212,-0.052184,-0.07314411,-0.03552078,0.10710182,5.194574e-05,0.12915759,-0.057287015,0.047376078,-0.050673444,-0.024767635,-0.0076637836,-0.038947687,0.004545463,-0.064577766,0.07389195,0.0033305846,0.049102683,-0.06285341,0.018159691,0.07366492,-0.024725428,0.13548216,-0.0077383355,0.008043533,0.14818367,0.01887204,-0.02888819,-0.007139426,0.020385187,0.009252484,0.04667828,-0.03755602,-0.057612248,-0.0074964385,0.086578436,-0.09794398,-0.01825451,0.0032462378,-0.08287172,-0.07692603,-0.0031531241,0.0056245527,0.0756727,0.04622713,0.016898502,-0.05315664,0.0031979633,-0.0075714667,-0.0044807927,-0.11889702,-0.006298615,0.0006172944,-0.0645755,0.081425846,-0.02288769,0.023658993,0.061792947,-0.07482142,0.011971404,-0.067067005,-0.0018309437,-0.05796865,0.004140135,-0.03953916,0.0667953,-0.0052072015,0.13563071,-0.0770716,1.7164594e-33,0.021491678,-0.054370843,0.07612099,-0.029474244,-0.014772152,-0.019794477,-0.03187434,-0.046947293,0.0021067443,-0.03664246,-0.0055378117,-0.06686316,0.070999175,-0.020193849,0.008915626,0.013072258,-0.06837088,0.1209766,0.081024304,-0.06654629,-0.058496356,0.062087666,0.08849492,-0.08078053,0.02900646,0.039838478,-0.12713921,-0.07044705,0.02166002,0.014019349,-0.017182563,-0.068145975,-0.059656806,0.023771882,0.028254895,0.017218668,-0.0305695,-0.09922799,-0.06272549,0.006555936,-0.049204294,-0.00066186924,-0.023329105,-0.01934603,-0.03184292,-0.017333515,-0.07332693,0.01901611,-0.009318676,0.046043683,0.027206093,-0.06190299,0.040291525,0.04784888,-0.07821513,-0.024713634,0.000839813,0.019309469,-0.019384682,-0.02745618,0.05288873,0.08539678,-0.025021957,0.025630193,0.04637801,0.042049497,-0.16253982,-0.09881511,-0.002889856,0.13465135,0.05586503,0.010858221,0.11565066,0.035483763,0.018091353,0.01992788,0.006028702,0.06078464,-0.028858723,0.082865015,-0.017021183,-0.05599837,-0.061486933,0.03689109,-0.021743653,0.01852204,0.1015426,0.0054133306,-0.0041779014,0.021085814,0.04679463,0.004236923,0.0026413922,0.030508902,-0.018432623,-2.6798222e-33,0.018785326,-0.055757523,0.034845963,-0.028005006,-0.0298469,0.040882412,0.01611291,-0.127291,0.020834293,-0.07016645,0.008251606,-0.025362996,0.0047524115,0.003127058,0.049802527,-0.047984045,-0.058374386,-0.0075616795,0.0028855286,-0.018940013,0.004975724,-0.044193313,0.017456818,0.16668314,0.027468624,-0.074948594,-0.024766212,0.048575424,-0.0006634276,0.0032013387,-0.0035813872,0.072928324,-0.096322626,-0.015009565,-0.0003337868,0.0017662919,-0.012023149,0.038286243,0.031670883,0.00745294,-0.065757714,0.03975107,0.07617063,-0.0141084185,0.009749802,0.13226232,0.06206756,0.098263316,0.026319971,-0.002327,-0.019743353,-0.009271019,-0.012872338,0.07628724,0.04050099,0.09641006,0.022561407,0.024356902,0.011731835,-0.08353668,-0.037189543,-0.034942724,-0.04409753,0.023933096,0.0373746,0.04435118,0.054370068,-0.05713919,-0.014466426,0.019283455,0.0061735995,0.047401898,0.07545254,0.031440467,0.06545034,-0.019654915,-0.004192365,-0.0016286051,0.02743224,-0.087320276,-0.018962419,0.082981855,0.0022626156,-0.06370443,0.001205792,-0.002288286,-0.026780475,0.06287955,0.073527955,0.044615943,-0.040754218,-0.027031783,-0.06938866,-0.047458597,-0.009743237,-2.8543832e-08,0.04670218,-0.019177802,0.02130691,-0.08849249,-0.027319299,0.026463123,0.023052745,0.052786868,0.06372256,-0.042895205,0.10128074,0.03388896,0.043506104,-0.06329998,0.04339595,-0.013462259,-0.005637525,0.041443527,-0.017518662,-0.09709385,-0.030339241,-0.048470195,-0.058905486,0.05679618,0.07535194,-0.032888204,-0.0073737954,-0.016451577,0.0071058804,-0.11159511,0.08412095,-0.029595697,0.03888511,-0.02501084,0.04124066,-0.020454759,-0.048703972,0.019424025,-0.030367004,0.041009147,-0.060375646,-0.048255127,-0.058427628,-0.051783126,0.012185802,0.035665385,0.04659577,-0.008868792,-0.051342357,0.0070697265,-0.054465763,-0.0014481994,0.008510016,0.0069787516,-0.041906334,-0.05572453,-0.039615933,-0.048491925,0.017130556,-0.055518936,0.0033395842,0.05168573,0.06118462,-0.014285435 +2.7.1.132,Also phosphorylates casein. The acceptor is a serine residue in the protein.,384,0.99999994,-0.05345898,-0.016281266,-0.05290551,-0.02144337,0.06938578,-0.01645564,0.0919362,0.04873372,0.07663634,-0.023096891,0.07053281,0.07236451,-0.05072832,0.07032474,-0.03840843,-0.0085534975,-0.046016295,0.0324506,-0.018548071,-0.0398264,0.030911198,0.097548075,-0.021889923,-0.022068156,-0.07841413,-0.044106953,0.03122134,-0.03142584,0.03565993,-0.04412207,-0.034875557,0.04180408,0.011675263,0.017108314,-0.015517977,0.085924305,-0.02132645,-0.060854573,-0.0013026283,-0.02760262,0.09013559,0.0027950793,0.07593651,0.008031232,-0.046274003,0.006637321,-0.032223735,0.024574446,0.07946325,0.033206344,-0.025719464,-0.050843894,0.0049710865,0.12721789,-0.026751518,0.062520824,-0.04575239,0.0006370337,-0.018242404,-0.036188863,-0.07860554,-0.07127969,0.027740741,0.021569846,0.12191851,-0.045529086,0.038343083,-0.048994683,-0.039905313,-0.06283664,0.068323605,-0.0047781705,0.01461634,0.05008047,-0.008679113,0.09421672,-0.049622945,-0.0115823485,0.06476221,0.035989527,0.025148822,0.02686305,0.024085367,0.07822555,0.004674954,0.017223539,-0.009827952,-0.020030554,-0.02198296,0.029607724,0.037933722,-0.090009,-0.029618919,-0.062026706,-0.035003763,-0.05391617,0.04074507,0.020926567,-0.011813487,-0.010209814,-0.022283716,0.044241335,0.031774465,-0.05615915,-0.04051357,1.943425e-06,-0.018104462,-0.010026718,0.011253694,-0.048836894,-0.008578381,-0.046814397,0.12476805,0.0027019507,-0.013148836,0.006342624,0.059052426,-0.006999584,0.02139921,-0.061705235,0.0002198236,0.026535306,0.015083458,0.038918134,-0.07196142,0.01149286,-0.095451385,-6.3112746e-34,-0.0034334322,-0.041519374,0.05351105,-0.035253342,2.1868507e-05,-0.019957537,-0.07790354,-0.019874193,0.018203352,-0.08171452,-0.10372357,-0.082868345,0.04805972,-0.008558345,-0.027033089,-0.09291512,-0.019423096,0.06548495,0.084673174,-0.050600532,0.019084206,0.05917246,-0.042753953,0.015549364,-0.03952956,0.052244544,-0.00049693935,0.014590708,0.03959431,-0.020402713,0.07080111,0.012366949,-0.06317162,0.050432432,0.018601753,0.035386726,0.039853305,-0.023802599,0.03815154,-0.015678287,0.010661945,-0.042748027,-0.07271222,0.012759994,0.009379938,-0.07924464,-0.07000343,-0.060047228,-0.0047890767,0.020678358,0.03193716,-0.061433163,0.041063443,-0.09601952,-0.064087465,-0.035612762,-0.010675219,0.019353768,-0.018728705,0.10162939,-0.018625263,0.061964568,-0.051427945,0.055643216,-0.03754323,0.025564732,-0.07197524,-0.12719811,-0.04993205,0.08261381,-0.039210048,0.033825427,0.12653676,0.105043925,0.021876602,-0.037972573,-0.058854476,-0.0017273485,-0.072252244,0.042705387,-0.082403354,-0.053745415,-0.08083186,0.13835157,-0.08833418,-0.025367483,0.036926165,-0.060535416,-0.006846015,-0.068279535,0.04351984,-0.03799652,-0.07253316,0.08709921,0.010898769,-1.906729e-33,0.03482976,-0.14429908,0.069028914,-0.008857326,0.0067887898,0.04293403,0.056760237,-0.005427523,0.062430616,-0.04838639,0.03280959,-0.0347968,-0.040640067,0.007989987,-0.0017109758,0.050460394,-0.056126866,0.057596836,-0.026341265,0.01581615,-0.019533267,0.018471418,-0.0002606515,0.04877061,0.049463086,0.04917963,-0.05845692,0.009713947,-0.004262319,0.076517545,-0.048947614,-0.0076324157,-0.10408885,-0.08343666,-0.0727896,-0.002275862,-0.019510236,-0.044783063,-0.0049837246,-0.034416676,0.008366985,0.015538257,0.036155876,0.12629047,0.041700628,0.032675035,0.06435827,0.009476187,-0.001579499,-0.022334833,-0.0026601811,0.018001165,0.028739588,0.019991739,0.051136084,0.06847201,0.042352505,-0.044751212,-0.022186039,0.00023818066,0.0016127012,-0.037101243,-0.0014401388,0.021991076,0.019930473,-0.0100781815,-0.016959988,0.002705841,0.053394873,-0.023753226,0.08409442,0.016363826,0.07254624,0.081890054,0.092636846,-0.012480353,-0.042085405,-0.0061071496,0.00832846,-0.03659959,-0.10581815,-0.0006891782,-0.04913968,-0.041256204,0.053533494,0.048197422,0.021067498,-0.0030065037,-0.07028497,0.009363687,-0.035231482,0.01572978,-0.06508796,0.08005359,-0.012510527,-2.474858e-08,0.07558136,-0.08699194,0.03391146,-0.1331107,-0.027533444,0.030362658,0.040536482,0.041651227,-0.012925874,-0.02723431,-0.026670016,0.08693538,-0.04047727,-0.063569725,0.03221203,0.065360695,-0.058508217,0.02697093,-0.060087524,-0.01482055,-0.05405486,-0.019055406,-0.02925304,-0.019246416,-0.013754267,0.027763389,0.048976067,0.08281298,-0.069234215,-0.052558046,0.06803039,-0.0069170026,0.0026609688,-0.06760215,0.016515616,0.10558235,0.03775884,-0.07321964,0.016979761,0.05165109,-0.026420388,-0.06170936,-0.030811353,-0.0020245002,-0.01179241,0.04924896,0.035749633,0.030731767,-0.02304575,-0.03551752,0.035923403,-0.049313057,-0.0422293,-0.005593503,-0.06734341,-0.009403934,0.040977154,-0.051918626,0.07089313,-0.042036187,0.0350787,0.06469736,0.17984115,0.024573477 +2.7.1.134,"This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP. The enzymes from animals and plants also have the activity of EC 2.7.1.159, inositol-1,3,4-trisphosphate 5/6-kinase.",384,1.0,-0.086769044,-0.021958314,-0.05436291,-0.007207461,0.101899154,0.0016879626,0.010594483,0.0020356188,0.06259401,0.052529424,0.058596957,-0.013017827,-0.08749866,0.010071372,0.0060042567,-0.005528955,-0.05127158,0.045376558,-0.010751954,-0.061697733,0.06204738,-0.02013567,-0.0720758,0.009517011,0.040715292,-0.039586905,0.07505531,0.021304332,-0.044972923,-0.12339661,-0.06583823,-0.07846948,0.028062295,-0.060997948,0.0034387128,0.12497225,-0.03804625,-0.1367437,0.03012417,0.017502736,0.12692803,0.0074464483,-0.04148354,-0.080540635,-0.08688669,-0.024937768,-0.027127542,0.020467134,0.06672111,-0.07361281,-0.021852655,-0.010457153,-0.013475506,0.004321448,-0.10842297,-0.02946477,-0.048619192,0.08499947,-0.05514195,0.04282884,0.045574833,0.022074774,0.052422624,0.07413741,-0.0018820079,-0.026441563,0.050692856,-0.0018965788,-0.01632286,-0.012138622,-0.062552564,-0.023069827,-0.014336458,0.038598083,0.024298117,0.04692555,-0.04062405,-0.015228299,0.043511156,-0.047820877,0.04679753,-0.0027876394,-0.019464657,0.028830038,0.025496496,-0.03695678,-0.059124596,0.031916488,0.018305253,0.03532293,0.055085894,-0.014872586,-0.018470965,-0.04629577,0.030537456,0.058961526,0.012618959,0.045156196,0.0013982021,-0.046112064,0.0026507427,0.102063864,-0.08100162,-0.0645576,0.01377814,0.016667828,-0.020750161,0.002089415,0.04645278,0.058368776,-0.043751653,-0.07366013,0.09724537,0.0033025488,0.014357356,0.08426186,-0.06658514,-0.060669392,0.009800109,0.0031251702,0.03660992,-0.043387827,0.038772583,0.111408405,-0.040528316,0.07587401,-0.060116116,3.4972474e-33,0.029949734,0.03691929,0.041985586,-0.029607393,0.014352794,-0.03407143,-0.024718458,-0.025128655,-0.09433631,-0.030135805,-0.04885635,-0.05870292,0.09433309,-0.035293177,0.014416346,-0.028685836,-0.0168036,0.05543204,0.0828231,-0.0005842078,0.01921446,0.01833152,-0.08687873,0.023209285,0.029806428,0.094549224,-0.0719697,-0.010416232,0.0072663375,0.0016530989,0.0052188155,-0.064831026,-0.120619036,0.046397194,0.03574097,-0.07666828,-0.05470742,-0.03885512,0.009507935,0.03826007,-0.009432642,-0.037099447,0.03555154,-0.030913712,0.029080145,-0.029834477,-0.047731087,0.06649904,0.07905575,0.036652133,0.044754934,-0.04709556,0.1223352,-0.05301161,-0.072869696,-0.013288134,-0.055123452,0.005143964,0.023081854,0.0672791,-0.0003767356,0.0614665,-0.06067649,0.039807923,-0.0060599516,0.055859428,-0.11256913,-0.085985646,-0.009289823,0.09038989,-0.069137104,-0.027678832,0.018003898,-0.022274554,0.008254352,0.023788752,-0.023990793,0.013404112,-0.071490616,0.07751804,-0.05692363,-0.06194775,0.08042007,0.02734339,-0.027176501,-0.027264223,0.038657136,0.023643088,0.03595756,0.03547093,0.13827008,-0.046075154,-0.08287842,0.06074434,-0.0051507903,-4.9588288e-33,0.11091917,-0.013303035,0.07795937,-0.1163043,-0.12533753,0.09023519,0.04083648,0.03336559,0.060894288,-0.013222073,0.045240883,-0.021303687,0.0069203824,-0.04418349,0.0030072555,-0.008770451,-0.052114237,0.087645955,0.019868355,0.028552217,-0.008250729,0.04215388,0.017268313,0.061491225,0.03360604,-0.0035639515,0.0021060205,0.0038297167,0.015223963,0.027979385,-0.026467143,0.007834145,-0.033514477,0.011045556,-0.043140728,-0.03347535,-0.06965436,-0.030318078,-0.0018559577,0.052958205,0.004910933,0.07062166,0.036338944,0.002130698,0.026272206,0.05965912,-0.032323264,0.06742675,-0.084814444,-0.0033227885,-0.0039180415,0.07429566,-0.022605758,0.07933572,0.03550724,0.010340763,-0.003397,0.06428371,-0.018272383,-0.024032203,-0.057191014,-0.089541756,0.058561273,0.0055962997,0.04964504,0.042761408,-0.028122919,0.015189409,-0.04111711,0.016691396,0.03804387,0.014197733,-0.03785612,-0.03968872,0.03377482,0.010238789,-0.048145816,-0.020773146,-0.009355935,-0.061401825,-0.033109087,-0.008180771,-0.07929418,-0.07830229,-0.024943473,-0.02480093,0.013511204,0.12948622,0.071229585,0.046832416,-0.031545874,-0.02052685,-0.004666978,0.016997784,0.060186144,-4.9597958e-08,0.035085015,-0.01802411,0.08215359,-0.023044381,-0.003709729,-0.011756698,0.05713054,0.027628519,0.047042564,0.010421874,0.0005886415,0.052340116,0.07779159,-0.05740779,0.056752846,-0.011512671,-0.0062997066,0.07777424,0.017085072,-0.009905464,-0.020394415,-0.080160655,-0.15348719,0.038327996,0.06834531,-0.03405391,0.049208447,0.022958102,0.019096356,-0.017614739,-0.034240738,-0.022989457,0.008535287,-0.006138874,-0.051491745,0.03400466,-0.059111282,-0.04325972,-0.096432395,0.03121357,-0.062369946,-0.055398293,-0.054037616,-0.008955437,0.00048087823,0.034108426,0.027681531,-0.025506161,0.03502683,-0.04993355,-0.03459398,-0.027574146,-0.02065896,-0.11344465,-0.040343907,-0.03232558,-0.013388649,-0.016229458,-0.034270033,0.030150091,0.037555344,0.046719823,0.12884046,-0.027898202 +2.7.1.135,"Activated by tubulin. Different from EC 2.7.1.123 Ca2+/calmodulin-dependent protein kinase: not activated by calmodulin, cyclic nucleotides or Ca2+. Involved in the formation of paired helical filaments in brain. See comment on EC 2.7.1.37 protein kinase.",384,1.0,-0.027867176,-0.0852089,-0.025874045,-0.007922851,0.022395276,0.04764233,0.04185605,0.057359837,0.012044223,0.03923932,0.08024492,-0.009059031,0.008977281,0.029723616,-0.0015098318,0.010730088,-0.03483105,0.01961514,0.012968586,-0.056720432,-0.0131618595,0.009879466,-0.025749905,0.034303855,-0.023460956,0.039564602,-0.02949023,0.04967057,0.06371011,-0.038697153,-0.06407911,0.0023612462,-0.029662767,-0.08602799,-0.028163105,0.012544535,-0.09285499,-0.11523509,-0.075887166,-0.0386748,0.08377957,-0.0892641,-0.016360883,-0.034981005,0.05023351,0.0021809076,0.039269235,0.017061979,0.0033646664,-0.032448497,-0.016029803,-0.018291283,0.009440846,0.01644088,-0.045428317,0.03204039,-0.0875024,0.06991816,0.06429216,0.0009938537,-0.075769074,0.0047373637,0.08646187,-0.021380447,0.053548906,0.004181628,-0.058257084,-0.07663987,0.033939082,-0.009226209,-0.025488904,-0.08131681,0.08509599,0.018320464,0.029114444,-0.05229588,-0.04511996,0.012433445,-0.0010204646,-0.023266327,0.041589398,-0.07235615,-0.008461723,0.05104975,-0.009597446,0.040326104,0.01269958,0.04939391,-0.009903478,0.052488066,0.09526195,-0.020447271,0.071677655,-0.068523705,-0.07161559,-0.021105094,-0.040641326,0.12084219,-0.023087725,0.006300754,0.03170625,0.02829164,-0.1232484,-0.01748676,0.035948053,-0.0006532176,0.029151065,-0.046002198,-0.010634188,-0.047878295,-0.021819822,-0.07297034,0.017359119,-0.010537034,-0.018696984,0.09497422,0.036715236,-0.016838523,0.11122401,-0.039068744,0.07990349,-0.0719224,0.015597002,-0.016412672,-0.066129245,0.01682543,-0.119068846,2.7153648e-33,0.019038357,-0.08787154,0.036717378,-0.008495517,-0.015413593,-0.01683262,0.0019706467,-0.065646365,0.052259438,-0.11260327,-0.06282539,-0.00454084,0.08493774,0.09053914,-0.05649444,-0.10027028,-0.03581811,-0.08161231,0.040838826,-0.003540234,0.12282981,0.08026875,-0.0061063706,0.029338395,0.037810832,-0.015070083,-0.08983324,0.05704686,-0.044589788,0.042873178,-0.051772654,-0.034724448,-0.06638069,-0.0002033829,0.03381286,0.0046086973,-0.0044910596,-0.027267758,0.027281327,0.055093225,0.0058135227,0.028407745,-0.03247034,0.034042083,0.0049036434,0.010014121,-0.06875271,0.10146632,0.08456937,-0.03418602,0.08035752,-0.03273015,-0.008542646,-0.0861271,0.05453719,0.03397142,-0.08067252,-0.022935176,-0.014064769,0.058117833,-0.019854052,-0.007218843,-0.06821019,0.012993814,0.043994647,0.12286884,-0.049907207,-0.032421645,-0.007504988,-0.06946471,-0.053213194,0.070383064,0.0856922,-0.013785208,-2.4596617e-05,-0.022373399,-0.027486242,0.038417038,-0.110047214,0.061376438,-0.0150033645,-0.03704689,-0.0057063955,0.06331872,-0.023125095,0.01028098,0.04864868,0.050637465,-0.046997957,0.0038358246,0.05581956,0.036747042,-0.005634465,0.085968435,-0.007036193,-4.3057994e-33,0.029662747,-0.031783704,0.046075292,0.05227152,0.0074023716,0.07911374,0.076350175,-0.1153762,0.065724015,0.03740304,0.05062598,0.024843235,0.0061169844,-0.01504083,0.037592787,0.0010794543,-0.12026421,0.0040713553,-0.043971166,-0.00020789327,-0.08199404,0.0108438125,-0.022847356,0.04744576,0.062290832,-0.0046946784,-0.07363066,0.04038508,0.023106439,0.06356306,-0.1330702,0.025321,-0.04131482,-0.02476007,0.0056674373,0.0039672046,-0.009825311,-0.053405024,-0.04390189,-0.05522156,0.017955502,0.05566172,-0.029299855,0.027736537,0.029926231,0.089843735,0.05506758,0.03400165,-0.143,0.010283693,0.024038732,-0.0062051867,-0.0112108905,0.060404766,-0.008246995,0.024745252,0.0242293,0.07807542,0.033581216,0.0657704,0.00437017,-0.07207473,0.0010598669,-0.0340023,0.0828256,-0.0029597962,-0.025752386,0.02916683,-0.0033922319,-0.027935332,0.065594815,-0.0068941372,0.054551825,-0.01319958,0.0090373205,0.025354184,-0.05433686,0.017739652,-0.019023499,-0.078857206,-0.041768227,0.08664557,-0.04896398,-0.012564875,-0.0054982887,0.10773195,-0.016694738,0.023438653,-0.017761504,-0.007469126,-0.020559218,-0.07426742,-0.092289746,0.1037069,0.037813038,-3.8209798e-08,0.010551011,-0.013474128,-0.0233125,-0.011696744,0.06277112,-0.014826704,0.013403428,0.081749626,0.009669052,-0.029201211,0.0057251872,0.030393198,0.089287825,-0.036112525,0.019493224,0.090970404,0.044000987,0.036631726,-0.014036148,-0.015166023,0.03478913,-0.10830363,-0.041853707,0.055890456,-0.025213422,-0.040860977,0.022258958,0.12010263,-0.04969229,-0.129035,-0.016246099,-0.045424458,-0.006814,-0.08060589,-0.046865694,0.04202519,-0.049399417,-0.073962264,-0.009595796,0.04018227,-0.038522154,-0.033546723,0.0023645216,-0.018138858,-0.032180857,-0.007631274,0.07714513,-0.029104063,-0.01264238,-0.049407154,0.015173831,-0.0017596624,0.043315537,-0.068877846,-0.056086976,-0.010038016,-0.006761689,-0.0060100257,0.0055685365,-0.03997113,0.03777376,0.024388246,0.110017434,-0.035195034 +2.7.1.136,"Erythromycin, spiramycin and some other macrolide antibiotics can also act as acceptors.",384,1.0,-0.057416134,-0.038838286,-0.045836523,0.0047117732,0.047061503,-0.023045642,0.046232373,0.0525547,0.06418157,0.0043181633,0.05948502,0.041129,0.04126103,0.13327692,0.01999387,0.021584181,-0.028881187,0.07825168,-0.00094701146,0.038436484,-0.057351887,0.07542573,0.044138126,0.030977339,-0.06728741,-0.034325004,-0.027030636,0.04335821,-0.0281036,-0.07420021,-0.010377416,0.0028395741,0.04822943,0.0027618054,-0.018888397,0.001663579,-0.09610328,0.020373758,0.10475763,0.0003625144,0.011701531,-0.032195892,0.034671728,-0.0087290555,-0.021819653,-0.032748044,-0.004970651,0.02276054,0.051394667,0.009048679,-0.011849515,0.015747743,-0.020765847,0.098026626,0.011454937,0.022190006,-0.12854353,-0.061671972,0.000822197,-0.013330614,0.0017040705,-0.07388239,-0.014407878,-0.005097814,-0.1333465,-0.025724005,0.009410632,-0.031992182,0.008240024,0.060380545,0.010471068,-0.047637437,-0.01579691,0.08232115,0.077431284,0.002598875,-0.017935365,0.011439505,-0.013707418,0.03536012,-0.030655023,-0.022999952,-0.00020395982,0.06632307,0.05534912,-0.024740268,-0.0047325846,0.06722927,-0.004557689,0.059252094,0.028750934,-0.011345131,0.08793974,-0.0570446,-0.0018929305,-0.06557756,-0.020244189,-0.03307234,-0.0128781255,-0.00991302,-0.08407436,-0.05907479,-0.037887804,-0.024957199,-0.00944848,0.00018684067,0.006346835,-0.0631498,-0.026303353,-0.047058232,-0.0338131,-0.095905095,0.05792398,-0.01673631,-0.040799025,0.051691752,0.10773277,-0.072961025,-0.043351054,-0.0689377,-0.023691213,0.025077196,0.010024705,-0.038252864,0.0039736573,-0.024607686,-0.022998752,1.9201427e-33,-0.049880177,0.019097177,-0.0256534,0.007987687,0.01535513,0.039660446,-0.013779792,-0.047149267,-0.0069842087,-0.09484623,-0.122178316,-0.012974934,0.059998244,0.108527906,-0.055066787,0.015975546,0.022227135,0.079451464,0.0128428675,-0.0017348084,0.08630549,0.026858011,-0.044661686,0.016771924,-0.026436916,0.046694584,-0.044781998,-0.0030672627,0.11420065,-0.050223134,0.038560748,-0.019581305,0.023695068,0.026763473,-0.014316917,0.057233136,0.0059339497,0.016205214,0.031171327,-0.02518156,-0.056923904,0.0492679,-0.14864337,0.040327005,0.077675596,-0.0024886392,-0.05407436,-0.016653778,0.03587856,0.050216604,0.0707578,-0.06445962,-0.011282599,-0.061517462,-0.031491287,-0.0016375434,-0.0050317063,0.10032967,0.005303998,0.0033640377,-0.008175443,0.023041721,-0.013276264,-0.024051867,0.003927835,0.030155836,-0.04140347,-0.06798071,-0.08846779,-0.0024027503,-0.040901065,0.009496656,-0.008726764,0.054927893,0.05677374,-0.041340254,-0.10768302,-0.0028666246,0.09686145,-0.007347039,-0.104402475,-0.08173137,-0.0023301218,0.12614399,-0.06761136,-0.015994838,-0.019743124,-0.009137439,0.053384222,-0.020597415,0.0040179733,-0.08450469,-0.06929198,0.050499164,0.02091987,-3.7099318e-33,0.076232806,-0.029029591,0.0699975,0.06644566,0.022870978,0.15222615,0.004254648,-0.06589689,0.09187848,-0.012007911,0.04671171,-0.0037046042,-0.046881262,-0.0037271867,-0.019367924,-0.063723296,0.022777513,0.070212334,-0.08772744,0.013820475,-0.062751524,0.008658276,0.014874313,-0.013442906,0.011473675,0.08199233,-0.019684441,0.018637482,0.017700428,0.045459203,-0.056837153,-0.016522177,-0.07209054,-0.109353155,0.056907732,0.07899172,-0.07109204,0.0154369045,-0.08164445,-0.088643126,0.05116733,-0.06150695,-0.024922835,0.14483425,0.034316435,-0.0061929664,0.022818113,0.047932442,-0.016312577,-0.06831608,-0.010435259,0.06134003,0.052001737,-0.0073124315,0.0482666,0.030927913,0.0906647,-0.07238833,0.017251745,-0.009913599,-0.051904492,-0.033427928,0.04578243,-0.0071463413,0.00490241,0.02288097,-0.031371575,0.055284392,0.06314476,-0.069023184,0.06484861,-0.0019545944,0.0001601079,0.0016529225,0.016430065,0.02986648,-0.029773027,-0.11353703,0.023917839,0.061735354,-0.0689363,-0.0005440496,0.0020262874,0.015693197,0.0021508639,-0.0059612356,-0.02799293,-0.10473631,-0.01430439,0.018949458,0.03824747,0.020816782,0.026682934,0.031346466,-0.007813947,-2.6543198e-08,0.07675404,0.0128088035,0.033273336,-0.024881141,-0.02306102,-0.036829844,-0.081943795,-0.007889262,-0.0029785521,0.008337729,0.020995423,0.069892034,0.055208754,-0.019918703,0.07215297,-0.0023595449,-0.015779354,0.010188198,-0.04508876,-0.021043377,-0.1456801,-0.024479454,-0.027805485,-0.02293197,0.051317118,-0.014984101,-0.002954781,-0.035380278,-0.00020774035,-0.01595966,0.08540646,-0.044237267,-0.012411178,0.05095858,0.02645994,-0.01628358,-0.0035269049,-0.0549321,0.022616416,-0.008284611,0.06476466,-0.061475784,-0.0934186,0.02050538,-0.047375973,0.06590365,-0.029481806,-0.09980973,-0.059052344,-0.011863311,0.047513317,-0.009112843,0.046361566,0.035945483,-0.10617886,0.057753883,0.02188588,-0.07220786,0.027936991,-0.09146681,-0.07991189,-0.01517331,0.13008015,0.07230019 +2.7.1.137,One mammalian isoform is known.,384,0.99999994,-0.05492887,-0.03861033,-0.006023708,0.018914701,-0.099408954,-0.024019131,0.006860341,-0.0063901083,0.021063203,0.038938176,0.0920569,-0.067529224,-0.08569645,0.07909874,0.022890376,-0.026798839,-0.09753596,0.03862574,0.047340468,0.02411858,0.014752304,0.044748448,0.0022271397,0.007074453,0.026950452,-0.060205564,-0.002265009,0.012996165,0.013122508,-0.10485971,-0.05383047,-0.06503611,0.081039146,-0.03224352,0.036568787,-0.06605337,-0.036524583,0.01151295,0.08179195,-0.000797172,0.074913934,-0.06179485,0.0037721314,-0.017889848,-0.020742808,-0.017916206,-0.057118632,-0.0066032857,0.039626487,0.04920646,-0.007077083,-0.084141515,-0.11169636,0.122674294,-0.015968906,-0.031476542,-0.058614474,-0.015110496,0.027212862,-0.02990107,-0.025760118,-0.0054017133,0.007151612,0.024864556,0.04729519,0.011060446,0.03184864,-0.03320265,-0.05408753,-0.0098565705,0.0563949,-0.045554154,-0.034853145,0.03742677,-0.10582941,0.04328616,0.012748678,0.043007042,0.029201914,0.007558411,0.019684644,0.058074255,0.001130766,0.024889143,0.03270405,0.026015969,-0.06588814,-0.021321282,-0.13054505,-0.021904645,-0.010173563,0.027479349,0.021165958,-0.028157601,0.020671528,0.024841862,0.0722388,0.08925344,0.07577561,-0.00079244864,-0.016427819,-0.018074552,-0.063489355,-0.042375635,0.05580316,-0.005713091,-0.053773094,-0.037760627,0.07561602,0.0032458443,-0.021778671,-0.025907079,-0.0027166167,0.05162179,0.08561238,-0.0002751504,0.014933963,0.006505481,0.032900028,-0.020284712,-0.07100971,0.022908568,0.034603436,0.026268154,0.013363645,-0.031607956,-0.013454244,-4.404243e-33,0.06254981,-0.003559581,0.0150315175,0.09194793,-0.01996335,0.040022794,-0.04830699,-0.048001535,-0.046517815,-0.05589753,-0.12081154,-0.013986895,-0.015362678,0.039333273,-0.064266324,0.029763209,-0.005060686,0.058045346,0.06317962,-0.10242747,0.0065862467,0.12459919,0.03911297,-0.09466645,0.004296173,-0.01703575,-0.10804927,-0.04451275,-0.017821662,0.0024325084,-0.042481944,-0.028927276,-0.090471156,0.025961164,-0.03295969,-0.041271273,0.003083196,-0.10194976,-0.01246019,0.08704149,0.11144351,-0.018218055,-0.028504664,-0.12767541,0.09138537,0.06347005,-0.06861348,0.00941271,0.0034575777,-0.04118831,-0.022407932,0.057588104,0.03131192,-0.03106229,-0.07259904,-0.008522406,0.032044377,-0.08374565,-0.070013076,0.036328077,-0.009241559,0.061007172,0.015118353,0.01963406,0.022159388,0.031257384,-0.14625925,-0.06879817,-0.0623371,0.052623734,-0.012095512,-0.061700672,0.015784804,-0.121317096,-0.015999824,-0.03554249,-0.010569694,0.035932016,-0.048664067,0.03341521,-0.121781796,0.07684912,-0.0773799,0.00024823716,-0.026426649,0.03644033,0.08102482,-0.0030010585,0.030264648,0.030865613,0.05291547,0.011344255,-0.12223873,-0.038604204,0.03589557,1.2624927e-33,-0.055966247,-0.052754004,0.034925286,-0.05300987,-0.05530289,0.11161035,0.009301507,0.0530849,-0.047549553,0.08041395,0.055390306,0.019226512,-0.025057115,-0.08758497,0.05941619,-0.011270164,0.027907677,0.09042855,0.050366085,-0.030044204,-0.05370318,-0.022203045,-0.06989977,0.094554015,0.064489014,0.007580981,0.029314127,0.032187365,0.015475517,0.008635275,-0.03761313,0.038048696,-0.004051278,-0.037339244,0.069392845,0.02939139,-0.05203437,0.046878673,-0.031581696,-0.08925016,-0.034511168,0.04520837,-0.026135206,0.06733642,0.038738433,0.010316534,0.06684756,0.023534508,-0.04891787,0.08128409,0.041426104,-0.004540185,-0.022133024,-0.05623318,0.0155907795,0.0113503365,-0.10748312,-0.0039067413,0.05262416,-0.033619113,-0.007471668,0.013394088,0.0048364927,-0.012672058,0.085428104,-0.0138089955,-0.010077553,0.02115657,-0.07455837,0.0100210365,0.14396445,0.020850552,-0.0059916805,-0.027578456,0.06467411,0.040662274,0.020129029,-0.061743125,-0.05455389,0.020917414,-0.037335154,-0.013661303,0.0038943812,0.021178113,0.00638304,0.02301297,0.0064879204,0.10119008,0.051618155,0.06502748,0.011381519,-0.019829696,-0.07073947,0.03788437,0.038664367,-1.7648198e-08,0.03727414,0.0013242323,0.074355766,-0.074001774,-0.075113595,0.07263938,-0.01794845,0.020547355,0.033732302,0.03617186,0.020859132,0.044215962,0.09974718,0.06679262,0.062428433,0.054122355,-0.027118893,0.073673666,-0.0060257004,0.051593494,-0.11126651,-0.022384956,-0.027716134,-0.0011187294,-0.033068456,-0.048775133,-0.0054026446,0.080152296,0.011805635,-0.049921155,0.048622314,-0.02191982,0.03570594,-0.0280055,0.016526971,0.024353553,0.0550426,-0.035403125,0.0010310869,0.022095043,-0.019631531,-0.043211285,-0.015377192,0.006362267,0.05925358,0.017767932,0.0013459459,-0.0003728434,-0.039243475,-0.011005027,-0.07604349,0.03262531,-0.010638726,-0.0451107,-0.057444364,-0.025094202,-0.04079254,-0.014743445,0.04446723,0.041919217,0.060595807,0.006367385,0.12720828,0.01938351 +2.7.1.140,"The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P5 as a substrate [2].",384,1.0,-0.05686297,-0.06347218,-0.027886653,-0.04400407,0.11929632,0.019500893,0.009763492,0.039582476,-0.008472347,0.04230573,0.060161926,0.022540467,-0.121293694,0.070380606,-0.018286282,-0.004313512,-0.057063017,0.0047810073,0.015330053,-0.017954547,0.06363624,0.013714894,-0.033126727,0.0022287874,0.010111108,-0.016425787,0.070622735,0.08490224,0.01870583,-0.10177836,-0.04780537,0.032280874,0.02311803,-0.07624148,-0.0036030822,0.032205295,-0.06010774,-0.0674927,0.036533568,-0.010324486,0.14396195,-0.06889664,-0.042509913,-0.008345162,-0.06314857,-0.01705651,-0.023134863,0.034207564,0.063748665,-0.06614221,-0.013788807,-0.029922387,-0.03482455,-0.020983117,-0.066305906,-0.03706216,-0.01369797,0.025878279,-0.051421195,0.029388955,0.054186843,0.049770508,0.0022120595,0.02309796,-0.011411904,-0.014793001,0.028727515,0.03493601,0.008960202,0.012441813,-0.077234685,-0.049122326,-0.034632653,-0.004107432,-0.013895258,0.036588196,0.018963618,-0.087531395,0.02491867,-0.025876109,-0.03751898,0.028453685,0.07094108,0.07840286,0.044176813,-0.028398583,-0.013328955,0.032148287,-0.0032725676,-0.032508463,0.061187204,0.04604268,-0.055065177,0.036919434,-0.04155149,0.06889238,-0.04235125,-0.005050447,0.012632957,-0.034746137,0.007171282,0.03291377,-0.06242708,-0.044616133,-0.06257085,-0.0004607912,-0.038664207,-0.019401558,0.05473602,0.008528191,-0.077814244,-0.02570065,0.00072157197,-0.02603278,0.04263681,0.018360587,-0.008452916,0.00054212095,0.038119324,-0.0267713,-0.040225357,0.048296068,0.024799278,0.07595155,-0.10678488,-0.0066889175,-0.06898064,-3.5121552e-33,0.0134093575,0.022135014,0.01644486,-0.012894513,0.008986934,-0.04112307,-0.049427148,-0.034223557,-0.083605275,-0.043387573,-0.095851354,-0.11839288,0.01769956,0.022766171,0.064135335,0.011211695,0.01890919,0.056483798,0.082826406,0.06046009,0.00082998147,-0.021691108,-0.0660619,0.010169126,0.08275616,0.10814427,0.032931246,0.022239877,0.015400405,-0.036687378,0.016057601,-0.04135348,-0.030687215,0.027692173,0.057931412,-0.014775546,0.0021735958,0.0348569,-0.011247631,0.024123846,0.04782599,0.0065247077,0.114351496,-0.0023315072,0.08813668,-0.027112247,-0.09867752,0.058334082,0.066517115,0.04897975,0.018044516,0.014391704,0.105355434,0.004745715,-0.018188631,0.047719836,-0.04170345,0.09221942,0.037242074,0.02011517,-0.04027006,0.089284845,-0.038053628,0.071043074,0.008536185,0.10819687,-0.09903913,-0.009462611,-0.0072530103,0.09772664,-0.10620167,0.02039528,-0.0030404092,-0.012634412,0.05645696,-0.034229502,-0.063960396,0.024540707,0.009307862,0.08310273,-0.04444522,-0.10807842,-0.01964347,-0.025072776,-0.129652,-0.02096933,0.012717694,0.02542869,0.025919022,0.004354141,0.13998583,-0.10434778,-0.0024540552,0.04851303,-0.06322142,8.068598e-34,0.11268903,-0.047924656,0.09940247,-0.09080869,-0.092629544,0.07461048,0.07312276,-0.08404942,0.0072788987,0.0545482,0.060142852,0.032975968,-0.023910012,-0.02071329,-0.0059858565,0.02120453,-0.054189645,0.08238631,0.038569838,0.019887455,-0.008449446,0.07689165,-0.028787488,0.04622142,0.024576034,0.012604622,0.06618062,0.017850747,0.0019223334,-0.0042756433,-0.045240942,-0.0025494727,-0.006586713,-0.024886804,-0.052496348,-0.023391154,-0.056987844,-0.032196686,-0.09382229,0.047023807,0.003132914,0.097386345,-0.006948014,0.06455998,-0.06045161,0.058799,0.008706309,0.014026115,-0.026792599,-0.008293163,0.003200264,0.033808015,-0.06263984,-0.011916289,-0.007970401,-0.050504386,-0.008778341,0.025730915,-0.026548807,-0.0006134595,-0.029589517,-0.05710906,0.047769744,-0.043346044,0.016485658,0.06176676,-0.026637321,0.045792583,-0.012488472,-0.029993292,0.041400213,0.06352711,0.041701704,0.014991224,-0.057688292,-0.019621471,-0.020105375,-0.011226535,-0.022940908,-0.006020929,-0.006048879,-0.059432175,-0.11012908,-0.015353476,0.0051480564,-0.097861506,0.051224448,0.10129053,0.0652381,0.05292637,-0.00908112,0.057482943,0.0032555382,0.029223686,0.07620683,-2.6371387e-08,0.037989236,-0.017601937,0.06750515,-0.07263649,-0.02248515,-0.015074854,0.023907458,-0.010658911,0.06850854,0.025888495,-0.08030775,0.09103793,0.03450048,-0.008633233,0.048955135,-0.045279145,0.0014143178,0.0296225,0.008002935,-0.022834802,-0.065449364,-0.018933114,-0.14329624,0.007672233,0.04375316,-0.07826082,0.02518131,-0.0058705057,0.03697145,-0.057811737,-0.009438114,0.040868524,-0.0078831725,0.014379938,-0.019270414,0.12077796,-0.020692041,-0.072624445,-0.0713871,0.024707694,-0.016311567,-0.1146612,-0.035466217,-0.052605025,-0.019161856,-0.02618004,-0.014707841,-0.017605606,0.022089811,-0.0074100792,-0.010851848,0.01188644,-0.017940538,-0.068108484,-0.038593482,0.02459745,-0.01960852,-0.052547034,-0.03755636,-0.026536737,0.0071151825,-0.041085042,0.18244204,-0.057298027 +2.7.1.141,The enzyme appears to be distinct from other protein phosphokinases. It brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6 DNA-directed RNA polymerase.,384,0.99999994,-0.021815773,-0.042500794,-0.042634364,-0.07098719,0.0116762435,0.04348931,-0.037018858,0.01445168,0.02244628,0.022783551,0.0018558387,-0.03181641,-0.07029155,0.030040337,-0.015539541,0.015174604,-0.12847961,-0.02073848,0.008282163,-0.086127125,0.100107215,0.049242802,0.02550552,0.027915586,-0.07810049,-0.0068702674,0.07657675,-0.03690587,-0.030510563,-0.07621478,-0.04058601,-0.10432078,-0.014762937,0.014171855,0.06839614,0.061710857,-0.038035806,-0.09667543,0.010769783,0.05351517,0.123345755,0.013613287,0.014566852,-0.065270156,-0.07636883,0.050680503,-0.013171901,0.03195086,0.050791807,0.0014772138,0.03152927,-0.06119025,-0.012884385,-0.017000224,-0.0019484975,0.083785474,-0.07228768,0.005839144,0.05178404,0.00089429837,-0.008125726,0.013475985,0.064221755,0.06996674,0.064198144,-0.09721059,0.06815614,-0.043266762,-0.04491238,0.011875538,-0.015483911,-0.03724652,-0.019523585,0.077924185,0.06423142,0.015515744,-0.032065578,-0.029675081,0.005824432,-0.03703149,0.0004912086,-0.06803776,0.0006346662,0.0006097429,-0.06657287,0.018001651,0.009489441,0.013115707,0.045305815,0.04014963,0.0018460723,-0.10372734,0.03200709,-0.0046758135,-0.030573236,0.031636484,0.044553492,0.10140005,0.03370095,-0.082054876,0.010713626,0.06983828,0.028273618,-0.09813795,0.024720052,-0.017847529,-0.0053291772,0.0073809936,0.04904625,-0.00929544,-0.020379612,0.021658616,0.0668981,-0.041109197,0.04085966,0.010678114,-0.00016408974,-0.04504747,-0.0028472636,0.052689567,0.04733393,-0.09403169,0.015871868,0.048748676,-0.05689332,0.00704855,-0.11151969,1.09520285e-33,0.011380116,0.04190767,0.06287529,-0.0661209,0.026407115,0.035318904,-0.044911157,0.046450447,-0.14302287,-0.078757465,-0.066596635,0.001608403,0.04830018,0.026185343,-0.045990627,-0.0104463715,0.0034068178,0.067690924,-0.036108565,-0.05323956,0.041781615,-0.001289153,-0.027552933,0.033604305,0.041898753,0.030994536,-0.024950262,0.018634124,0.06076512,-0.011041981,0.0039004812,-0.05298403,-0.096706584,0.053273544,0.066605404,-0.060776338,0.054907374,-0.04106042,-0.00615955,-0.0007721473,-0.014072072,-0.06569172,-0.020378595,-0.031545527,0.029843584,-0.061341915,-0.10415164,0.011718896,-0.0019943316,0.05192682,0.05001527,-0.05256793,0.1428823,-0.0034979777,0.02495469,-0.0419858,-0.064298786,-0.06516757,0.033244334,0.055215806,-0.04006576,0.09752448,-0.07183055,0.043936964,-0.026328541,0.018806407,-0.029938212,-0.08041778,0.015951356,0.09407485,-0.02030024,-0.05046024,0.07360879,-0.031901203,0.010972557,-0.05189857,-0.082307994,-0.023740215,-0.07148519,0.109815136,-0.06350148,-0.037401266,-0.014264085,0.011161651,-0.025064452,-0.03309332,0.054678615,-0.039866917,-0.017622203,0.06896366,0.04882588,-0.03169062,0.019194474,0.07570018,0.016178653,-3.025322e-33,0.052667733,-0.051534414,0.08026287,-0.033300802,-0.029356135,-0.021617005,0.065129995,0.006835857,-0.026511172,-0.091951154,0.05558006,-0.016845299,0.061497655,-0.027654758,0.055270206,0.035499748,0.00084796967,0.09313971,-0.001073918,-0.01112415,0.0406852,-0.010381419,-0.036898125,0.085950725,0.07816457,-0.027501153,-0.030933924,0.08383286,-0.004525338,-0.0060719405,-0.061162803,-0.0014021402,0.0040724413,0.07539958,-0.04024712,-0.025162015,0.0075607277,-0.014868697,0.06656313,0.022331772,0.0020898131,0.027186148,-0.031529024,0.029281247,0.04155547,0.106006734,-0.0019158989,0.09233699,-0.0096336305,-0.017694142,-0.029953057,-0.006510786,-0.008655691,0.057034735,0.022457138,-0.0040331054,-0.034852333,0.09858118,0.021892855,-0.06404214,-0.031240756,-0.09156854,0.05180833,0.12896468,0.061026756,0.016867941,-0.018494423,0.042211518,-0.0316094,-0.049639832,0.015807461,0.028685626,-0.016013155,0.02096466,-0.011170543,-0.009734777,-0.06131154,-0.04538293,-0.006507937,-0.03395375,-0.032720108,-0.017950138,0.047357287,-0.08027857,0.007099895,0.014457573,0.05310054,0.02910327,-0.011422021,0.044881623,-0.013288585,-0.033909418,-0.038735736,0.018345738,0.034082774,-3.366966e-08,-0.0018691926,-0.025342463,0.039895345,-0.062242553,0.086105056,-0.0076760487,0.049259182,0.06477047,0.0494228,0.029619247,0.030090272,-0.00934548,0.02375549,-0.021539206,0.11130822,-0.008714009,-0.08974465,0.03501184,0.021633413,0.058911413,-0.004478494,0.026337618,-0.11393483,0.055826068,-0.07799815,0.00033443733,0.073517054,0.06824703,-0.048817813,-0.02892926,-0.051260367,-0.029743414,0.017151013,-0.028443847,-0.115307875,-0.022478953,0.013123999,-0.008898823,-0.0874069,0.031173473,0.0041166907,-0.070473686,0.0013192807,-0.029553752,-0.027420025,0.030173676,0.05138126,0.053493075,0.013204624,-0.041399725,0.0059742834,-0.0040261615,0.0062479977,-0.10029112,-0.07489443,-0.055605844,-0.07155111,-0.06375309,-0.05387084,-0.008756315,0.04627863,0.02593606,0.21171184,-0.008539589 +2.7.1.142,Involved in the anaerobic metabolism of sugars in the bloodstream of trypanosomes.,384,0.99999994,0.044227436,-0.016260093,-0.13016862,-0.014639707,-0.015091557,-0.020655164,0.058078237,-0.022057895,0.02675729,0.075737834,0.0038396092,-0.07845643,-0.0569999,0.06852605,-0.076803,-0.037184972,0.014677611,-0.027082793,0.017246595,-0.009172361,0.06139364,0.038959857,0.1160081,0.033330716,-0.011425506,0.0026309849,0.008823303,-0.018479798,-0.06732905,0.009650826,-0.12102996,0.011643627,-0.006932478,-0.037000854,-0.0094661405,0.08666008,-0.017308779,0.059745304,0.009751857,-0.055041015,0.048403706,-0.0036037008,-0.017673708,0.053140156,-0.041690476,-0.016668512,-0.02024156,-0.0017417762,0.07160055,-0.034078497,-0.058572594,-0.05461264,-0.033205125,-0.02097489,0.033300932,0.027817946,-0.021618463,0.00250047,0.019743899,0.020903956,-0.06552298,-0.0020580045,-0.0123877805,-0.024117157,0.043678977,-0.11462827,-0.00061110326,0.031736754,0.0035617268,0.0005861431,-0.030462166,-0.05295157,-0.042215083,0.012938159,-0.05263706,0.03127796,0.05259051,-0.021872792,-0.031045241,-0.05931161,0.003164051,-0.04583727,0.10095691,0.0426769,-0.03340439,0.005014058,0.03196175,0.11422839,0.06315834,0.036401372,0.010422121,0.03632751,0.049115468,0.014660452,-0.053981557,-0.029647417,-0.017170358,0.028307365,0.030690372,-0.025630655,0.0919423,0.009420285,0.05475142,-0.016486024,0.08211769,0.016189601,0.08621877,0.090473264,0.075963624,0.026769297,0.030566031,0.06523644,0.078885995,0.04673311,-0.033962805,-0.025049707,-0.013296347,0.008482569,-0.08202171,0.06964892,-0.04746003,0.011132017,-0.018288113,-0.04383432,0.030708278,0.0087733045,-0.025198845,-2.2139685e-33,0.048747826,-0.045808997,0.025903353,0.06960641,-0.029482007,0.030946659,-0.05557403,-0.012522214,0.079873994,0.00952655,-0.08261925,-0.078195065,0.007183392,0.04068935,-0.0151450625,-0.002087869,-0.0445771,-0.06502489,0.0776216,0.06349392,-0.12166492,8.076822e-05,-0.017091064,-0.09815348,0.05902941,0.018188674,-0.085912466,-0.0032736778,-0.046241,-0.022146836,0.033491414,-0.056770105,-0.051951706,0.06818291,0.05842775,0.033228982,0.08571606,0.047685485,-0.07280861,-0.031493094,-0.0046357415,0.06803189,0.018768243,-0.040552344,-0.02057839,0.009412697,-0.029027933,0.09853273,0.057379894,0.09390195,0.045899965,-0.04303854,0.12154514,0.05229072,-0.02481547,0.06471842,0.03408887,0.028907623,0.06130533,0.060200643,-0.029624732,0.04276232,-0.058776837,0.04064407,-0.01663739,0.006949764,-0.08963085,-0.07007951,-0.043269806,-0.055029217,-0.067587316,-0.063964784,0.03869322,-0.04847413,-0.0076091927,0.004176309,-0.03589937,-0.048881173,-0.071493514,-0.032850474,0.08294349,-0.12354653,-0.026603766,-0.053607002,-0.105961755,0.13696265,0.02706602,-0.008736867,0.011059583,-0.052527767,0.023668993,-0.021800932,-0.0492809,-0.02239296,0.020162508,-1.5177919e-34,0.09399722,-0.05096892,0.042461745,-0.08750641,0.04713504,0.04075556,0.018560221,-0.07459539,-0.045750074,-0.039129604,0.04556531,-0.0063817683,-0.008423438,-0.010963299,0.024444286,0.024943408,-0.029113084,0.046799585,0.03555285,-0.025748605,-0.10092721,0.11407664,-0.06981548,-0.01630908,0.026801467,0.034914773,0.0141801005,0.066610664,-0.027388891,-0.06491656,0.059184086,-0.102550276,-0.044389315,-0.056455627,0.085118346,-0.009337133,-0.015941206,-0.004436256,-0.045080714,0.04555852,-0.002344377,0.09010739,0.01896703,0.017361302,0.01636783,0.058217384,-0.0744904,-0.03259032,-0.109826356,-0.027332263,0.05650263,-0.03697184,-0.05647551,0.050260346,0.07341652,0.0062878532,0.018904937,-0.009330814,-0.037451122,-0.07561091,-0.094496205,-0.058928546,0.045618646,-0.03938678,0.029979331,0.028129444,-0.06716918,0.08177848,0.013340558,0.061161537,0.0035494,-0.030589638,0.003546567,0.025834022,-0.091216065,0.0077980515,-0.0306012,-0.036428347,0.0572962,-0.05266284,0.017340178,-0.012892454,0.025933396,-0.023588682,-0.036164556,-0.08446124,0.019366344,-0.041066308,-0.0030010145,0.02873571,0.06657956,-0.088935696,0.04819938,0.052545156,0.053223655,-1.9171285e-08,0.07262878,-0.048510946,0.01539642,0.042216443,0.0069797994,-0.020181144,-0.0002873268,0.038794506,0.074322164,0.06539797,-0.007198202,0.049085025,0.033846177,0.012737455,-0.049657535,0.048010375,0.025500404,0.009697273,-0.0027887018,-0.006387506,-0.13252822,-0.029309377,-0.09909883,0.052325156,0.032860912,-0.056106452,0.05289802,-0.006010797,0.009348717,-0.048346072,-0.065162785,0.04077411,0.029638393,-0.01568752,-0.03979773,-0.0049979673,0.023131084,-0.050877955,0.022072794,-0.007394133,-0.011140937,-0.058431674,-0.043797567,-0.014163227,-0.010840703,-0.0082792705,0.024742419,0.055783156,0.0387717,-0.049701896,0.0315035,0.096246704,-0.021487782,-0.01671826,-0.03128633,-0.006363339,-0.055700574,0.06318953,-0.028544059,0.004496686,0.052766655,0.0822206,0.057220884,-0.15438236 +2.7.1.143,"The enzyme from the Acholeplasma class of Mollicutes catalyses the conversion of adenosine, guanosine and inosine to AMP, GMP and IMP. ATP cannot substitute for diphosphate as a substrate.",384,1.0,-0.07345137,0.010785868,0.0033426147,0.00286399,-0.050010633,-0.02919032,-0.014243148,0.033377558,0.010116524,0.0014320278,0.040575664,-0.028204713,-0.01941984,0.02416527,-0.037457958,0.036613595,-0.020289227,0.03219383,0.06733255,-0.07225795,0.10645501,0.010071423,-0.030317528,-0.03225829,0.023937337,0.0036857268,0.007953932,0.0071576713,-0.026858468,-0.08126597,-0.11878242,-0.06094646,-0.03147985,-0.024787847,0.09617714,0.11787996,-0.050926432,0.052772805,0.08881394,0.025195727,0.019181974,-0.012883283,0.023657037,0.0026188483,-0.03638974,-0.04490275,0.0143978195,0.020974204,0.012388128,0.02629463,-0.02869826,-0.045261018,-0.06458221,-0.024240006,0.033749264,-0.0046275677,-0.12328235,0.04854035,0.0054851766,0.026880203,-0.012186338,-0.011492706,-0.04650937,0.039516687,-0.005787397,-0.092739925,0.061014898,-0.036763277,0.038637497,0.05462762,-0.03991197,-0.014199317,0.0055240206,0.0040663816,0.03011,0.039826214,0.012724646,-0.016865056,0.06774316,0.03607008,0.060809802,0.030475805,0.0053099003,-0.02374602,0.101283655,-0.039989885,0.024747223,0.0052322247,0.026380688,-0.026608659,-0.048420403,0.00344021,-0.056537434,-0.032640934,0.017599123,0.046116415,0.01664119,-0.024903769,0.0015813814,0.021019949,0.04318118,0.059780464,-0.029436756,-0.094162,0.0046589007,0.010788088,-0.010736866,0.040523957,0.004457935,0.08907809,-0.02276,0.032275558,0.02872073,-0.016045619,0.02847257,0.08075767,-0.05162675,-0.05281492,-0.031324416,0.011459204,-0.10057534,-0.05413116,-0.053836994,0.060046256,-0.05589443,0.049086057,-0.04340607,1.796463e-33,0.042617295,0.01984115,0.019119903,-0.04473761,0.019473825,0.0015478724,-0.033896327,-0.003514407,-0.066033036,0.00014265622,-0.05427087,-0.072441496,0.0235127,0.020792997,-0.030143796,0.013994249,-0.001493997,0.012097064,0.048758406,-9.513752e-07,-0.060090203,0.041366693,-0.010082713,0.024691517,0.027037727,0.09219582,-0.08056784,-0.011135939,0.052502353,0.008153136,0.019132553,-0.029097486,-0.1051303,0.00278412,-0.01598652,-0.017603483,-0.032473486,-0.03433997,-0.001854357,0.0076207444,-0.12454846,0.040923156,0.0040001627,-0.030835008,-0.01020274,-0.051467635,-0.02001252,0.07513528,0.046309054,0.05570134,0.042911097,0.0036146094,0.027857408,-0.031938232,-0.04940356,-0.002545312,-0.058516476,-0.0047639506,-0.005670744,0.060251433,0.04057108,0.044095237,0.004902567,-0.003532429,-0.07960064,0.02668842,-0.09992388,-0.03414262,0.029835962,0.102518134,-0.017642973,-0.032388322,-0.040987268,0.029880662,0.0020448987,-0.050125327,0.066580504,0.034093246,-0.008737193,0.02425245,-0.020959496,-0.042448677,0.061813917,-0.101140104,-0.094325215,-0.020172225,-0.0011786846,-0.011486519,0.07665194,0.013477807,0.024573203,0.013631646,-0.082649425,0.013821718,-0.008830973,-3.41432e-33,0.10992127,-0.0019545495,0.029543811,-0.10998284,-0.11792849,0.06599119,0.0074301097,-0.08076536,-0.03855075,0.03117951,-0.020155884,0.04316149,0.048723154,-0.061310224,-0.045183137,-0.07284828,-0.047794294,0.044161238,0.0018878299,0.04597608,-0.018502068,0.13935906,0.055895317,0.030129751,0.005306112,0.001921379,-0.020680279,0.009211548,0.032252014,0.05652963,-0.05962607,-0.013799713,-0.079130515,-0.014786001,-0.033435464,-0.0014352784,0.027693545,0.031107673,-0.0531177,0.041947596,0.04358193,0.07220862,0.010281624,0.10891242,0.012756922,0.09002792,0.032960806,0.010052844,-0.031145282,-0.06814361,0.006927262,0.013676193,-0.012872276,-0.018866457,0.03999466,0.064329505,-0.027137797,-0.051728107,-0.024766231,-0.057025623,-0.050908457,-0.13027139,0.0006643209,-0.080129854,0.09569874,0.10943926,-0.051579334,0.063473105,-0.020143392,0.027089462,0.022939503,0.034699567,-0.04146498,-0.032132182,0.0340601,0.038656443,-0.03270664,-0.027328102,-0.023733571,-0.0783455,0.01771817,0.094984904,-0.04220512,-0.071172856,0.05891654,0.024890926,0.049462706,0.07996692,0.0019808318,0.06692779,-0.014630313,0.053671617,0.016942091,0.07930771,0.0491172,-3.2031895e-08,0.027711606,0.045546647,0.02401265,-0.042821247,-0.01768947,0.084587194,-0.019430226,0.021549888,0.09033441,0.0020632718,-0.08605743,0.062153358,0.07055065,0.011007752,0.046020124,0.024213446,-0.064982146,0.03631899,-0.029426511,-0.014005257,-0.09787189,-0.017011771,-0.12434652,0.16828299,0.024786854,-0.012306344,0.068008624,0.059601966,-0.09126215,0.042058174,-0.083823666,0.016075764,-0.037916303,-0.040390607,-0.009091313,0.0042390875,0.06933032,-0.012081861,-0.10812671,-0.03866179,-0.05902582,-0.08215616,0.019926598,-0.0009832351,-0.0536971,0.03648578,0.023095516,0.027526068,0.005312964,0.1273805,0.02846353,-0.037626848,0.0030096818,-0.06298076,-0.05344331,-0.097038336,-0.04668265,-0.06862003,-0.056978453,-0.029830217,0.001004132,0.024582468,0.19239965,-0.05714877 +2.7.1.145,The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.,384,1.0,-0.042844646,-0.015740862,-0.035203356,-0.06700095,0.021730907,0.00031449637,-0.023370354,0.00739319,0.036499344,0.027765898,0.060550317,-0.06667538,-0.111476846,-0.0005047055,-0.03464748,0.13551605,-0.079622366,0.024409879,-0.0237776,-0.053057402,-0.02442718,-0.011932527,0.018812986,0.03360733,0.019500144,0.0025500252,0.049727317,0.06562383,-0.075813964,-0.11125683,-0.011550657,-0.024965707,0.0035158733,0.031454403,0.0063996115,0.0439539,-0.024791596,-0.08185981,0.04610658,-0.06424958,0.087212324,0.071910724,-0.05086682,0.032507118,-0.060123138,0.049675602,0.00646544,0.030242853,0.097237654,-0.008743519,0.00913778,-0.04833348,0.0038403263,0.05979664,0.057624247,0.07638597,-0.01979805,0.04688272,0.038907338,-0.008865225,0.028220583,-0.003330376,0.033836637,-0.030679248,0.011359686,-0.009612403,0.031568594,-0.041027095,0.0023660993,-0.07816697,-0.06371136,0.012708016,0.054643992,0.044821095,-0.041048042,0.087788165,-0.032952186,0.009545289,0.012873571,-0.03129474,-0.041607503,-0.06570885,0.050656836,0.018988336,-0.032999005,-0.02545151,-0.0040092235,-0.012828331,-0.0037070534,0.077309415,0.051581897,-0.036103807,0.01040926,-0.033192202,-0.010226014,0.05335452,0.028415004,0.06723338,-0.045097023,-0.051646,-0.01761097,-0.008540477,0.005510477,-0.026605284,-0.022784282,-0.015572376,0.06551481,-0.09223449,0.040735207,0.008154978,-0.036872704,0.00018791592,0.06814066,0.075863056,-0.05245573,0.035496976,-0.028445996,0.006248972,0.09286567,0.051404964,0.042085733,0.019167526,0.02913433,0.0074914526,-0.0484936,-0.013240713,-0.10354475,4.8147826e-33,0.03193163,0.038844123,0.016379355,0.09826447,0.0022676836,-0.064376414,-0.012977546,0.016772525,-0.028313518,-0.09196549,-0.17958128,0.0016000639,0.091546595,0.027358197,-0.02800913,-0.0073393015,-0.039664183,-0.07965705,0.08148249,0.05899398,-0.023059981,-0.019793315,-0.022772279,-0.084376976,0.008600723,0.026930783,-0.08565098,0.030381236,0.018240605,0.010899958,0.012515679,-0.045019623,-0.0023028285,0.11205953,0.0774651,0.0029011783,-0.025957547,-0.053837456,0.008941088,0.045881268,-0.047215585,-0.0923028,-0.05203127,0.0146765215,0.009518203,-0.049561393,-0.041467704,0.045670927,0.04094373,0.022253962,0.008998542,-0.026778145,0.09834783,-0.13454464,0.04553667,-0.029146831,-0.03577951,-0.05339713,0.014193885,0.005979961,-0.0123761175,0.07381307,-0.03950755,0.028059565,0.060782716,0.018696096,-0.13260615,-0.028618408,-0.047267217,0.01703121,0.04654799,-0.064125806,0.029327795,-0.038656764,-0.034160335,0.028909799,0.020724412,0.031223066,-0.053447932,0.032673545,-0.007715689,-0.039297022,-0.020368198,-0.05598544,-0.058844876,-0.0018510295,0.0046622097,-0.03546174,0.037713736,0.11149034,-0.12824132,-0.027457045,-0.035293546,-0.039810047,0.10320409,-6.580557e-33,-0.00013868365,0.0045736707,-0.008304115,-0.018353885,-0.033397283,0.104415685,0.057028916,-0.03731076,0.06257766,0.010009695,0.0048654634,0.04051935,-0.020091066,-0.10094145,0.03056095,-0.013656369,-0.06614877,0.036625266,0.04407598,-0.0070999246,-0.018112065,0.11331194,-0.06780996,0.027745886,0.004035231,-0.05453633,-0.0074934573,0.093685195,-0.009502434,-0.04576998,-0.022187673,0.0033408748,0.08028284,0.07653917,0.016952226,-0.019891202,-0.06845453,-0.08060525,0.03790566,-0.0049817334,-0.033765,0.037152294,-0.07030959,-0.021348314,0.035384066,0.056480657,-0.04786088,-0.0036919948,0.025000783,-0.0719583,-0.023548234,0.00635092,-0.084253445,0.049710367,0.034752738,0.065395705,0.040751465,0.041892044,0.09565012,-0.014085856,-0.053241037,-0.10549483,0.08361065,0.040251862,-0.016564548,0.06046205,-0.0340645,0.07233064,0.007443208,0.047828153,0.020983236,-0.026609067,-0.026334256,0.0013447427,-0.18694907,-0.008906841,-0.010812842,0.008090461,0.01952028,-0.05737005,0.002813369,0.0015300006,-0.028345073,-0.04754866,0.019470643,0.021095386,0.0028336665,0.0463398,-0.085705034,-0.012032704,0.026949203,-0.05176203,-0.06745076,0.118184745,0.016608559,-4.3061654e-08,0.09038688,-0.003227748,0.04234777,-0.034349844,0.040459182,-0.005998997,0.043813255,0.0753054,0.037370045,-0.007145154,0.016875375,-0.013085806,0.028365536,0.009576083,0.08940426,0.050132163,-0.030388758,0.05232283,0.016720446,0.04311229,0.004833628,0.005587085,-0.06907661,0.04598801,0.0064793695,-0.04928693,0.0014047665,0.017734066,0.012371894,-0.0049421336,0.007935286,-0.010826642,0.04948464,-0.117497355,-0.039798144,-0.028231366,-0.074729174,-0.050660748,0.0025501524,0.036860824,0.009195687,-0.006526179,0.02394665,-0.0042219977,-0.0526892,-0.05049409,0.13330396,-0.035282258,-0.028725918,0.044100843,0.039098766,0.053705376,-0.021357244,-0.039796192,-0.09534645,0.0045114933,-0.040218443,-0.07581164,-0.072978005,-0.0652911,0.024973605,0.052977595,0.124404244,-0.04432366 +2.7.1.146,"ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.",384,1.0,-0.036177296,0.0074915886,0.02710352,0.02256462,0.030301576,-0.008234364,0.03617765,0.022777902,-0.060119003,0.0026576438,0.009432022,0.037720673,-0.08506606,0.04282259,0.039313972,-0.03603969,0.085590854,0.048586674,0.04491296,0.042909436,0.059984386,-0.001518002,-0.052384984,-0.023854343,-0.015762124,-0.018261516,-0.016121505,-0.019124579,-0.025128417,-0.02733444,-0.033141617,0.0041900417,0.06239161,-0.07558391,0.0076451097,0.077832766,-0.03470365,0.015566306,0.0010036695,-0.05689753,0.03260406,-0.016492771,-0.01910061,-0.022692952,0.032537475,-0.04949278,0.022882443,-0.02155876,-0.045893386,-0.0063986825,0.02600832,0.07210909,-0.022743393,0.037732206,-0.047395445,-0.012653161,-0.039458092,-0.0070679993,-0.060517482,-0.027156089,-0.04404917,0.028523272,-0.030402595,-0.037004974,0.09300128,0.023747744,0.08465628,-0.0036113265,0.027868353,0.10269498,-0.04480091,-0.022080505,-0.085777625,-0.03808166,-0.019898426,0.025873128,-0.043917835,-0.075772926,0.16474494,-0.009296939,0.094042264,0.0622176,-0.020166487,0.051243145,0.09665009,-0.029514141,-0.02649452,-0.029282311,0.004211678,-0.024220102,-0.017069172,0.075012445,0.08255363,0.023843661,-0.044060867,0.027923785,-0.023966197,-0.037557624,0.026667997,-0.023525221,0.00072302826,0.120622195,-0.03456258,-0.025789434,-0.045807,-0.034401298,0.011026242,0.06009149,0.0866848,0.084827214,0.022184107,0.040420696,-0.0049415915,-0.022793906,0.06262884,0.025474247,-0.055654287,-0.074593954,-0.0038273935,0.024729628,-0.0008939464,-0.054470167,-0.011969303,0.034114905,0.022472028,0.08652269,0.02964834,1.0486298e-33,-0.034208942,-0.016782423,0.06630167,-0.0033837317,-0.051152132,0.05297403,-0.08184023,-0.066855356,0.109066665,-0.052930683,-0.08006596,0.01418677,0.010199815,0.09463666,0.0013187086,-0.06770567,-0.036100812,0.035218935,0.17714585,-0.028619412,-0.0383729,0.06350752,-0.016320607,0.0067028985,0.114565305,0.042821057,-0.058855183,-0.0024906367,-0.0053374246,-0.0013908173,0.080048814,-0.08001915,-0.14622265,0.08156712,-0.06301579,-0.0046456154,-0.0965712,-0.05891833,0.025578428,-0.022046404,-0.019125892,0.049930267,0.067501605,0.023984179,0.044748977,0.0063159084,0.017476266,0.014889011,-0.056435566,-0.01151813,0.053459506,0.0015221535,-0.030805916,-0.08440644,-0.08541372,-7.0598246e-05,-0.018715018,-0.03011229,0.020247906,0.09411783,-0.004311342,0.04903048,0.018992618,0.031549312,0.026958877,0.09301783,-0.037483476,-0.12080316,0.0081624,0.024355542,-0.017810542,-0.07623149,0.11050761,0.041686084,-0.0068306327,-0.010430825,0.06427306,-0.015068424,-0.041948322,0.03808122,-0.12068009,-0.08136382,0.023316454,0.036261484,0.008620795,-0.044891007,-0.012466758,0.00128688,0.044994485,0.029436888,-0.00042764968,0.012169042,-0.08604294,0.045423713,-0.009180339,-3.1664964e-33,-0.0018203082,-0.02092423,0.033829648,-0.019603148,-0.08894755,0.02576857,0.043064974,-0.115565665,0.056582596,-0.053350314,0.009876466,-0.00811846,0.018138407,-0.02922413,-0.013796147,0.024990862,-0.10595182,0.0135937715,-0.032737546,-0.00283749,0.013329775,0.102065735,0.033680882,0.09547235,0.096427865,-0.0044549964,-0.047013756,-0.025501857,0.10846801,-0.03152326,0.0475335,0.057553902,-0.05240088,-0.0009252235,-0.007820055,0.02151519,0.025616154,-0.012052907,-0.08231548,0.046303045,-0.00543138,0.041662242,0.015241645,0.020365441,0.049824264,0.0739166,0.008881694,-0.0072162263,-0.0034607437,0.004295708,0.079324365,-0.01525492,-0.1253161,-0.059522152,-0.0029059337,0.0522283,0.053032212,-0.05822326,-0.028748581,-0.0936354,0.007535141,0.009773038,0.048160598,-0.012124054,-0.033002604,0.045955278,0.088318534,-0.023141997,-0.0021399464,-0.032926284,0.025758967,0.063506976,0.030223757,-0.046326287,-0.019596357,0.048513845,-0.0442162,-0.018962381,0.027621895,-0.08214641,-0.029415105,0.039078526,0.0020095143,-0.0825328,-0.040095054,-0.03705893,-0.04989536,-0.011285135,0.011692381,0.040978137,-0.1189777,-0.055559855,-0.08196562,0.0016414216,-0.02502967,-3.15553e-08,0.037646748,0.06788198,0.113979645,-0.030522864,-0.0402808,-0.005574025,-0.04930457,0.06784835,0.09044071,0.008422072,0.037119873,0.08122312,0.0011132263,-0.02990825,-0.01330065,-0.021886997,-0.03006627,-0.009586062,-0.08178354,-0.08026424,-0.064122364,0.028475445,-0.1143434,0.05006895,0.075078234,-0.073564254,0.040331706,-0.005806978,0.041168094,-0.034852527,0.04158634,-0.037369408,0.025613135,0.04117162,0.046332076,-0.01990957,0.00753109,-0.08297019,-0.07720415,0.01381205,-0.07896765,-0.0811254,-0.034993254,0.01723581,-0.0062428806,-0.04368331,-0.011968497,-0.042211544,0.0167672,0.0049980725,0.03172312,-0.020777006,-0.06463757,-0.046478715,-0.00039548575,-0.0031318446,-0.05890891,-0.013274538,-0.063171394,-0.020824838,0.006919129,-0.0027789462,0.037036177,-0.05774115 +2.7.1.147,"Requires Mg2+. The enzyme, characterized from a number of hyperthermophilic archaeal species, is highly specific for ADP. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate. ",384,0.99999994,-0.05231812,-0.049134653,0.032344356,0.007720193,0.05008999,-0.07232497,0.017498251,-0.0362792,-0.061932385,0.014101195,0.020509938,-0.04296022,-0.08147975,0.05249335,-0.002452249,0.01136633,0.04776385,0.021065585,0.10013701,0.024718642,0.11023789,0.010017009,-0.028153695,-0.044329684,0.00019611859,0.0086050145,0.051241256,-0.016535182,-0.041979343,0.012447099,-0.035256974,-0.06328784,0.088670395,-0.080789655,0.08255235,0.15827508,-0.05379447,-0.018155733,-0.023383802,-0.08213809,0.06727563,-0.026586236,0.033200126,-0.0016676553,-0.00047715116,-0.08286035,0.03788175,-0.04069883,-0.0099509405,0.029606374,-0.017803201,0.010707882,-0.009296638,-0.009216474,-0.058390394,0.022089964,-0.046013623,-0.022696542,-0.054276433,-0.04491223,-0.044824123,0.031703565,-0.029806588,-0.029624641,0.09440349,0.045858655,0.0980969,-0.06033342,0.05597661,0.011291751,-0.053579494,0.011213943,-0.053395595,0.017208777,-0.06397571,0.022767875,-0.027384443,-0.058561727,0.110077135,-0.08012974,0.045583636,-0.013907407,-0.016514156,0.05244449,0.084811725,-0.013905007,0.032208428,0.011445151,0.003260166,0.008313048,0.039359566,0.04497591,-0.006749734,-0.0002955203,-0.00827569,0.027633984,-0.0379785,0.03316166,-0.020868633,-0.010384864,-0.044143002,0.09504891,-0.040572174,0.0011871225,-0.012648942,-0.013272963,-0.043122113,0.019437006,0.072466284,0.07171127,0.067073025,0.010430071,0.06531658,0.021859363,0.07415378,0.043094095,-0.061087582,-0.10801094,-0.054624684,0.025891038,-0.0060189534,-0.060667906,0.021957839,0.014190872,0.003098674,0.059721727,-0.038488384,4.0130437e-33,0.03401098,-0.01490749,0.07535867,-0.021236371,-0.029332666,0.059657376,-0.05790534,-0.037324063,0.029715756,-0.03292884,-0.064785324,-0.067129016,0.044150252,0.064144224,-0.010068408,-0.025980538,0.019253489,0.016241672,0.17020722,0.005117557,-0.06469203,0.07380656,-0.030354181,0.0016279245,0.018892359,0.080527365,-0.028137453,-0.020506224,0.025962537,0.019369781,0.053342033,-0.16200982,-0.13983448,0.029201273,0.016090522,-0.0033940168,-0.041191496,-0.06617723,-0.02675378,-0.030198999,-0.047316056,0.012407779,0.032824945,0.038346056,0.039331328,-0.041807204,0.0053701308,0.05956387,-0.061548404,0.06893247,0.05768529,-0.04184947,0.02206488,-0.03392889,-0.07288062,0.023044797,-0.045353424,0.01662405,0.045101136,0.07082576,0.04279433,0.0400782,-0.007511849,0.07362253,-0.009898765,0.07462323,-0.052050084,-0.09946894,0.009300839,0.078593045,0.006386878,-0.06765426,0.06883993,0.065662675,-0.017261544,-0.011640553,0.006286319,0.01549561,-0.025673324,0.0034396467,-0.060300604,-0.08939728,0.055401254,0.050780866,-0.037685607,-0.004314921,-0.01174213,0.025673121,0.02378629,-0.001912855,0.07511678,0.0044675083,-0.08873182,0.07937823,-0.025296139,-5.2802758e-33,0.022811731,-0.029464614,0.06376364,-0.090997644,-0.11100195,0.041218672,0.05407239,-0.070718706,0.042982515,-0.03536135,0.08896804,-0.02107692,-0.027288128,-0.05976253,0.018492762,0.022648595,-0.08049841,0.048485085,0.012479322,0.03749211,0.029415857,0.12876342,0.021087876,0.105487086,0.078325026,-0.018801559,0.007034758,0.02849027,0.044691034,0.0014215003,0.03314195,0.12325359,-0.06585438,-0.025456404,-0.01715841,0.035465166,0.0029458664,-0.014945721,-0.04430882,0.08266244,0.01842691,0.099444516,-0.010138111,0.04497722,0.023238344,0.051857263,-0.0013528365,0.038332507,-0.012532013,-0.04991701,0.0079328725,-0.033041373,-0.03692095,-0.059980474,0.024374342,0.08659618,-0.026342776,0.013430445,-0.02755517,-0.053479504,0.0075049996,-0.029921558,0.04623141,-0.039468654,-0.005492875,0.07398931,0.068200335,-0.008925608,-0.01466392,0.012691094,0.023763305,0.025186203,-0.012243883,-0.020667844,-0.006750743,0.08700473,-0.07748919,-0.0061054714,0.055952393,-0.10978234,-0.003690717,0.054097228,0.01171791,-0.061738383,-0.036304783,-0.04327287,-0.045332838,0.002594341,-0.0045772903,-0.002419347,-0.06511108,-0.050584156,-0.11165823,0.018949665,-0.049657762,-3.712092e-08,0.03223097,0.045665935,0.10362171,-0.100780055,0.0128099965,0.048672237,-0.0025307196,-0.018314943,0.07239336,-0.025771804,0.03206786,0.016690826,-0.033680968,0.004540392,0.018531052,-0.010397008,-0.0037724224,0.02152692,-0.10486724,-0.060347244,-0.041221704,-0.038620245,-0.10821718,0.08640273,0.03286359,-0.081659116,0.05689627,0.027246343,0.026338924,-0.028630145,0.0056058355,-0.033019975,-0.023478324,-0.012295644,-0.04344746,0.049032457,-0.028194956,-0.06947337,-0.04654614,0.01034142,-0.1178265,-0.059244365,0.019707697,-0.01524751,-0.0065365355,0.009776176,-0.0050918693,-0.042548373,-0.030144611,0.0065560425,0.026560549,-0.050932806,-0.041558396,-0.079166435,-0.047727987,-0.003275126,-0.027709024,-0.051704872,-0.08249667,-0.037119295,0.07898391,0.015948491,0.043169934,-0.084325485 +2.7.1.148,"The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).",384,0.99999994,-0.021415422,-0.093508236,-0.042827375,0.04059962,-0.02208773,-0.014081022,-0.07627451,0.013149891,0.015640222,0.0005725838,0.061855935,-0.04690493,0.025662383,0.013761448,0.02000884,0.0078701805,0.0062254965,0.050919313,0.055072207,-0.016521584,0.11243496,0.10255539,-0.012455788,-0.07323178,0.0130896,0.025668554,0.065375395,0.0052012694,0.054876976,-0.013926262,-0.10089866,0.03214073,-0.0058401763,-0.11220373,0.08858695,0.069602646,-0.08723849,0.014381754,0.044690344,-0.075341456,0.049170583,0.0014695316,0.07140308,-0.059919786,0.0016966701,-0.0723663,0.01584796,-0.03569829,-0.009116519,-0.012960671,-0.064769566,-0.027963748,-0.03466306,0.026310153,-0.00026351263,-0.058556754,-0.0019494102,-0.07301892,-0.061484437,-0.04332878,0.01368646,-0.015377206,0.00047382576,-0.0070021898,0.017604757,-0.0043284977,-0.017456908,0.04094141,0.016063713,-0.02613267,-0.039300524,-0.047648903,-0.034790922,0.032560624,-0.057194628,0.0042144884,0.115253195,0.008265,0.061953414,0.012291669,0.026508762,0.008605299,0.06052256,0.12858146,0.07562441,0.021770112,0.043355666,0.034557655,0.02968049,0.11094998,0.0422157,0.06146614,0.026375419,-0.036845777,-0.0027009598,0.04843786,-0.03182072,-0.012494606,-0.01875742,-0.020879818,-0.016508782,0.05815442,-0.063032776,-0.0076127206,-0.012453851,0.013852584,0.014925349,0.04825879,0.005056011,0.0013645138,0.08031255,-0.014580836,0.0072103874,0.010934885,-0.019728549,0.029469375,0.016752828,-0.1230357,-0.0059602913,-0.009643486,0.021908436,-0.03189926,-0.055239316,0.072728686,-0.07904998,-0.0033905196,-0.074001744,3.2177384e-33,0.07550908,0.09291549,-0.002503068,-0.07098882,-0.009633433,0.03867227,-0.046638966,-0.022793738,-0.027690846,-0.012602433,-0.0967847,-0.10404124,0.019169006,-0.009594594,-0.018200638,-0.10375353,-0.015073868,0.084762715,0.115618736,-0.009704964,-0.06549706,0.09081839,0.0004587855,-0.036718138,0.009059094,0.11613711,0.010641602,-0.04526492,0.030643038,-0.013622761,0.025959602,-0.09483774,-0.048366636,-0.020127647,0.12117808,-0.050871227,-0.043530166,-0.008886864,-0.050445225,0.04332125,-0.04286519,0.07329076,-0.067893736,0.027453505,0.059699934,-0.103976704,-0.022157053,0.0302578,0.0074560507,0.07102634,-0.00239909,0.0505269,0.03364725,-0.046467047,-0.09394121,-0.013877834,-0.011626957,0.06798223,-0.0038971156,0.020940641,-0.00744169,0.02243892,-0.018826384,0.041693404,-0.017724523,0.048181444,-0.09960208,-0.089411944,0.0037472816,0.07130466,-0.026051743,-0.03641442,0.077931,0.0057746246,0.060958754,-0.032795865,-0.057081554,-0.00785569,0.053832762,-0.018380417,-0.008308988,-0.023606298,-0.051274497,-0.048067816,-0.028718665,-0.015907126,-0.01537235,-0.005208911,0.014636142,0.0132528,0.09974215,-0.0011182248,-0.098870814,0.05506833,-0.0032057625,-4.3135063e-33,0.035365358,-0.039579537,0.045215666,-0.108295046,-0.11296505,0.0118820835,-0.016399747,-0.07755609,0.069442004,0.02312712,0.079131916,0.006506674,0.04103588,-0.06842114,-0.04470834,-0.03744667,0.029968994,0.0931147,-0.025453286,-0.060008217,0.071996644,0.06811007,-0.010511852,0.04862965,-0.03478289,0.043050475,-0.0054638083,0.04201118,-0.01828764,0.086538754,0.01442,-0.008251805,-0.02711226,-0.009158178,-0.0422153,0.0902657,-0.015413477,0.014850463,0.04561036,0.06106084,0.019527754,-0.003206506,0.026941488,0.094828114,-0.0117407935,0.0032807183,-0.11874898,0.02635466,0.06736874,-0.08564417,0.040351223,-0.046232156,-0.024933482,-0.05636613,0.008503955,-0.011569176,-0.03198227,-0.026135638,0.052816562,-0.056370202,-0.008428292,-0.08186933,0.033709377,-0.06472188,0.01610193,0.02946141,-0.011012046,0.022456942,0.03506188,0.029859427,0.0037530418,0.11031952,0.041994482,-0.05165037,0.028215205,-0.011904789,-0.028671633,-0.0832222,0.032407496,-0.043407608,0.015847553,0.07405353,-0.025158482,-0.03442157,-0.012241193,-0.06646266,0.032762956,0.0879966,-0.01333736,0.04148222,-0.04288175,-0.031316284,-0.017238779,0.09637183,0.0024623543,-3.991035e-08,-0.016938685,-0.07948175,0.0064662374,-0.029260274,0.005340178,0.0780394,-0.039410826,-0.10370727,0.10389589,0.022307951,0.0025569852,0.0414983,-0.034408934,0.02616228,0.07711211,0.01442561,-0.0034450088,-0.026492571,-0.03316445,-0.101264976,-0.014070892,-0.035819836,-0.11255991,0.018505204,0.066770695,-0.07486015,-0.0411649,-0.028294275,-0.013425083,-0.04045352,0.006357641,0.004261057,-0.059466626,-0.0052455785,-0.08143697,0.07723357,-0.025789132,-0.04215108,-0.04281479,0.028602669,-0.029965792,0.02249239,-0.06413403,0.020903524,-0.05450868,0.036323935,-0.011227139,0.043479737,-0.08584946,-0.00058821624,0.039723482,-0.07944263,-0.02083638,-0.00941213,-0.058172297,0.011111102,0.054570276,-0.027077574,-0.042919777,-0.017737575,0.05678606,0.049766336,0.15116486,-0.036720887 +2.7.1.151,"This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4].",384,1.0,-0.06366818,-0.06515794,-0.043672856,-0.06561469,0.07260535,0.033985138,0.008950859,0.021224357,0.03794337,0.06371831,0.08430026,0.0026947993,-0.08738552,-0.02670295,-0.022001063,0.014937714,-0.059038967,0.03321918,-0.035172313,-0.06289197,0.077649884,0.018091708,-0.032005183,-0.005319438,0.030239375,-0.042262845,0.05712742,0.019931728,-0.011786247,-0.14182314,-0.05832251,-0.0030952988,0.012560547,-0.05337297,0.032295123,0.09745742,-0.0023829408,-0.08375082,0.05295669,-0.02404176,0.13279271,-0.021066833,-0.056287266,-0.03263749,-0.101658575,0.021923074,-0.0040892153,0.054593336,0.051883504,-0.07989644,-0.028557628,0.005932933,0.005223538,0.0045094136,-0.053095866,-0.028330203,-0.025300253,0.05152763,-0.0035714242,0.041357487,0.033730812,-0.006696292,0.045706462,0.049461577,0.0097662965,-0.039434887,0.063464165,0.05249842,-0.026027491,-0.024214175,-0.05904499,0.013352852,-0.05250644,0.018549332,0.014699461,0.08554197,0.00896355,-0.029922588,-0.024146957,-0.033248566,0.036959797,0.020014366,0.06568783,0.04397116,0.020254714,-0.049017683,-0.04600374,0.050263934,0.031010423,0.04044224,0.06845712,0.030363616,-0.03752659,-0.03366031,-0.017454552,0.0793773,-0.024498556,0.021210331,0.0017670799,-0.038848702,0.052231696,0.063641004,-0.07464302,-0.06768413,0.013217084,0.060034495,-0.033877194,-0.0073013343,0.03699588,0.051055826,-0.04913942,-0.046843987,0.023415862,-0.00012861406,0.020674681,0.0125640705,-0.037301835,-0.0011728766,0.028424244,-0.039294705,-0.007395156,0.02846396,0.032994963,0.08233515,-0.11557937,0.03544659,-0.11691036,1.1237401e-33,0.0033969264,0.072495274,-0.0016715059,-0.040146183,0.012351272,-0.04389688,-0.015578676,0.0050217826,-0.13171512,-0.006620666,-0.10235824,-0.06350775,0.033019572,-0.025353333,0.013062177,-0.0032227673,0.000762212,0.06251684,0.053757098,0.03202054,0.012046469,0.008926142,-0.09134014,-0.0014532651,0.046830155,0.12227054,0.018465107,-0.0065517426,-0.0026041288,-0.04802558,-0.018983671,-0.026319124,-0.024638372,0.014583278,0.08422815,-0.091075264,-0.0048917294,-0.006171305,-0.040316492,0.016228558,-0.025778808,-0.02321531,-0.0036139577,-0.016657397,0.038719937,-0.02521322,-0.02947748,0.016850337,0.10070176,0.056156665,0.0047750818,0.0058247885,0.12564622,-0.0050104884,-0.054331042,-0.013297399,-0.047763247,0.034539945,0.067223735,0.024861889,-0.05656918,0.07123663,-0.0565671,0.06850766,0.013938578,0.05214974,-0.114840575,-0.07862816,0.005058224,0.08837769,-0.08589377,-0.050096143,0.01971982,-0.012399465,0.06884083,-0.034599736,-0.063430645,0.005605616,-0.07028847,0.06574446,-0.020699227,-0.05939105,0.026784148,-0.012318179,-0.07367879,-0.028061155,0.032206833,0.014083692,0.0012535695,0.009446804,0.16971654,-0.07148598,-0.020676164,0.07553905,-0.014383324,-2.5901566e-33,0.116286196,0.008148722,0.11214559,-0.109416135,-0.091368146,0.101884,0.08569789,-0.042806633,-0.00022562144,-0.005989504,0.04954261,-0.022865463,-0.038777065,-0.019034207,-0.015514211,-0.0017317628,-0.004054886,0.08701576,0.017811893,0.051858503,-0.014140889,0.043217275,-0.033736818,0.07868866,0.030352537,0.012304781,0.11303112,0.04953163,-0.032543246,0.019594627,-0.013026258,0.027631532,-0.026336603,0.019556824,-0.0639598,-0.049094222,-0.07956461,-0.031051073,-0.036573853,0.06671962,0.01494123,0.09425746,-0.009323181,0.021637585,-0.027069569,0.034538135,-0.029912202,0.07324785,-0.05460911,0.0030531706,0.0017837846,0.07241817,-0.04908232,0.06887581,0.039744772,-0.042936467,0.00773746,0.0595663,-0.030645216,-0.0031152694,-0.05018801,-0.11107917,0.07906456,0.0031517881,0.06303432,0.056083277,-0.0046243765,0.011435934,-0.035253227,0.03763585,0.00689643,0.03044784,0.008096699,-0.02400243,0.02704071,0.011905432,-0.037111767,-0.051425364,-0.055526476,-0.035635974,-0.017087277,-0.042929597,-0.07726747,-0.033254236,-0.018126715,-0.04729687,0.07588356,0.13387081,0.04277215,0.060765736,0.030392218,0.030977156,-0.007940808,0.049214344,0.07991405,-4.752079e-08,0.0352683,-0.024098413,0.04482814,-0.060797498,-0.021418994,-0.037588816,0.040126726,0.012015573,0.02152261,0.004738554,-0.027513623,0.059299164,0.06953493,-0.04038427,0.10312929,-0.050995912,-0.017423138,0.067457944,0.013434679,0.0067669367,0.015666718,-0.0465754,-0.16856086,0.009039044,0.06345813,-0.061721418,0.037592992,0.007937546,0.06280457,-0.018323964,-0.0006475978,-0.016743347,-0.026873287,-0.06567294,-0.014803437,0.07708229,-0.035898127,-0.06425725,-0.055287804,-0.0045328164,-0.048734065,-0.08979583,-0.06384995,-0.021685695,-0.030513603,-0.014745738,0.010871294,-0.034234844,0.03755143,-0.007947511,-0.012997475,0.017955694,-0.020545932,-0.08662421,-0.029350081,0.0035014793,-0.020834848,-0.009533043,-0.071303986,-0.0018506754,0.011926547,-0.042697854,0.09589313,-0.050333545 +2.7.1.153,"This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.",384,1.0,-0.021929555,-0.068959035,-0.04629353,-0.038823303,-0.023825293,0.053999785,0.038281284,-0.015706528,0.08117204,0.05509074,0.0037862328,-0.007469318,-0.09298882,0.09936748,-0.025129497,-0.027838496,-0.12603402,0.036276553,0.062817,-0.0886468,-0.012637595,-0.031870887,-0.01860709,0.011143309,-0.025850518,0.009640607,0.08460934,-0.07747964,-0.010394925,-0.010927303,-0.07084762,-0.12028604,0.014797275,-0.057888716,0.02655044,0.058982324,-0.025168255,-0.025199188,0.0016436386,0.027404025,0.10291884,-0.032281544,-0.026331142,-0.008986699,-0.010022033,0.037211504,0.003463949,-0.011988313,0.080762886,-0.025396332,-0.026447026,0.0355581,-0.024196304,-0.013091737,-0.005902773,0.03041789,-0.041514374,0.03264743,0.042409394,0.04927767,-0.004187728,-0.006096456,-0.008246575,0.060775477,0.11090601,0.026580954,0.03818923,0.01647894,-0.0046930574,-0.009735243,-0.03792787,0.03367256,-0.006587817,-0.026218068,-0.0034150218,0.03509975,-0.014636497,-0.011021414,-0.020770067,-0.055147905,0.030923925,0.029479032,0.01903481,0.042639464,0.030280143,0.0057129236,-0.06358628,-0.07177153,0.016683362,0.008467724,-0.008808548,-0.006369479,-0.027920488,0.005212795,-0.010567072,0.075425275,0.02848979,0.010163258,0.057848938,-0.062084652,-0.022027243,0.08517028,-0.078944765,-0.06186878,0.045153998,0.063444436,-0.04736795,0.031578638,0.040008385,0.031490754,0.014897861,0.0071000713,0.02941722,0.000771493,0.06519161,0.044641946,-0.064808756,-0.08818021,0.014406464,0.032890838,-0.021828683,0.004972838,-0.025010245,0.07295944,-0.0767583,-0.008562922,-0.02654759,2.0878163e-33,0.012699947,0.10388446,0.03457104,0.03501284,0.036275182,0.0052759657,-0.030825684,-0.049268804,-0.086137265,-0.05980664,-0.052618288,-0.15406029,0.025467187,0.012833479,-0.062978625,-0.034095854,0.00455709,0.0937331,0.09301294,0.011663071,0.027049491,0.102876134,-0.014352199,-0.0015252974,0.050822034,0.06477413,-0.06864983,0.024893148,0.046008818,0.003718071,-0.035534363,-0.052530985,-0.10629853,0.0024582492,-0.06327749,-0.09918131,5.215453e-05,-0.07095612,0.03378173,0.04885194,0.012019003,-0.057119343,-0.060003527,-0.029028991,0.029587286,-0.05776046,-0.035076246,0.033103775,-0.036370903,0.045612223,0.041699864,-0.013177275,0.096453846,-0.013464628,-0.08418329,-0.05538266,-0.07831494,-0.06103976,0.07365062,0.046020705,0.08378357,0.0756873,-0.051944688,0.020567939,0.035332814,0.019455364,-0.04500501,-0.080675334,0.044937003,0.10809066,-0.05416788,-0.017385429,0.035005778,-0.029147405,0.099318616,-0.023273911,-0.056084964,0.03757292,-0.02739004,0.03227432,-0.11935197,-0.01831718,0.015807467,0.10590356,0.021446485,-0.063883774,0.05304127,-0.054350395,-0.0013815841,-0.022437783,0.06579593,-0.042058703,-0.07581709,0.03225505,-0.012396018,-4.4634013e-33,0.076267295,0.021517726,0.014672538,-0.08588536,-0.14250642,-0.0013326118,-0.020142823,-0.03957566,0.011530324,0.0030311977,0.0555607,-0.041495677,0.011240209,-0.074892715,-0.046017725,0.03820112,-0.0062244604,0.055055026,-0.017906962,-0.02987616,0.021836696,-0.014450155,-0.037038613,0.1488749,0.07352257,-0.041310042,0.02703865,0.008745062,0.0067419284,0.08137546,-0.005467955,0.027385188,-0.036587574,0.023138642,0.003264369,-0.011198246,-0.014910791,0.052585647,0.02956416,0.01347508,0.07870169,0.06597779,0.041086636,0.0034074476,-0.041812915,0.038886033,0.0031407727,0.09300205,-0.053019386,-0.06032756,0.013830835,0.010844909,-0.0134720085,-0.02477442,0.01183166,0.031107822,0.020632187,-0.003048475,0.041563116,-0.054367356,-0.09271312,-0.067853674,0.077781595,0.077605516,0.094869286,-0.001982551,-0.047797505,-0.020597545,-0.036098804,-0.0010399064,0.08093248,0.046004508,0.020046623,0.064387776,0.005108868,0.044060826,0.0009695625,-0.06502935,0.021341467,-0.04256285,-0.0010777441,-0.030968025,0.046868447,-0.09853816,-0.056785487,-0.025642356,0.039158773,0.13020614,0.01768476,0.016559301,0.015276811,-0.03792178,-0.04337058,-0.0054802396,0.08835115,-3.378906e-08,0.04537259,0.014197204,0.04595257,-0.06342429,-0.12906127,0.053375274,0.020614153,0.065088965,0.0068300157,-0.03267978,-0.008062592,-0.046567928,0.03958776,-0.013471301,0.087854154,0.06588927,-0.038190536,-0.017580805,-0.025147872,-0.03544365,-0.08169506,0.0020819488,-0.12235867,0.02638751,0.028890286,-0.028778175,0.0120392125,0.024426175,0.014464102,-0.07148597,0.042257704,-0.017413396,-0.038366105,-0.056930985,0.033285953,0.029057233,-0.039856613,-0.038244218,-0.050737325,0.06056297,-0.09196234,-0.06039396,-0.040542375,-0.036393862,-0.03844782,0.049272154,-0.018946161,0.03355896,-0.026563043,-0.03451558,0.009113106,0.016629739,-0.033701155,-0.092860974,-0.06185008,0.014492427,-0.07408885,-0.03590797,-0.03612889,-0.061685078,0.027076647,0.06824312,0.13601443,-0.01278348 +2.7.1.154,This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.,384,0.99999994,-0.06800255,-0.106946014,-0.058557756,-0.035732944,-0.010499561,0.04078602,0.052948963,-0.022577727,0.09581822,0.048299603,0.026813153,-0.0017008355,-0.092810154,0.109101236,-0.009817494,-0.051887713,-0.09053624,0.008444338,0.10314279,-0.08110165,-0.035444945,0.019187849,0.006002053,0.0370738,-0.01568467,-0.013603154,0.077224195,-0.06390308,-0.014444267,0.008119797,-0.099176094,-0.10055156,0.018931804,-0.040422615,0.02614726,0.067874186,-0.036833305,-0.0404461,-0.015564748,0.018952992,0.08585826,-0.039655,-0.013880996,-0.023937898,0.0038313686,0.030282468,-0.014332812,0.008353092,0.07555972,0.010423605,-0.019212095,0.010996479,0.036299523,-0.004311924,0.008285027,0.05024642,-0.038416155,0.043432932,0.026568418,0.04714448,-0.06358495,0.004696417,0.006350627,0.038344905,0.12430958,0.025562607,0.028190145,0.014586254,0.00982282,-0.024131523,-0.051291663,0.018767951,0.016108355,-0.014346723,-0.01740122,0.064041086,0.0031161967,-0.00039077512,-0.044177733,-0.07776072,0.021341685,0.04095309,0.0032238762,0.0755288,0.02408745,-0.011128856,-0.06016568,-0.03311536,-0.032487873,0.0025451577,-0.013503454,-0.0048525934,-0.03187336,0.010883927,-0.022096071,0.06252996,0.007308297,0.029770043,0.00977386,-0.07152337,-0.041271623,0.09865837,-0.04570035,-0.02519161,0.04733411,0.06174562,-0.06142026,0.017198943,0.030704917,0.011376727,0.035212386,0.02942442,0.038075216,-0.030381214,0.067682125,0.013247344,-0.08006545,-0.086419076,0.05996156,0.034859587,-0.014613928,-0.0107520865,-0.046100356,0.08160805,-0.0962584,0.014510313,0.008088601,5.0233736e-34,0.004275819,0.07651048,-0.0010416054,0.023694063,0.042241227,0.007358221,-0.011792886,-0.055377237,-0.06533956,-0.06767556,-0.042892963,-0.13659224,0.015142901,-0.0048449608,-0.074353606,-0.017995361,-0.034119826,0.10194036,0.07402026,0.0122730965,0.056019634,0.07758962,-0.014249233,-0.028517244,0.042182304,0.032597873,-0.0846578,0.040101722,0.037883498,0.0017083313,-0.00940643,-0.048919432,-0.08705495,0.026199762,-0.064536855,-0.07005469,0.034904886,-0.100256525,0.022999646,0.05827801,0.04632442,-0.050319552,-0.045697447,-0.005231916,0.003957381,-0.060491614,-0.0328258,-0.003397416,-0.06721521,0.02728861,0.0509805,-0.0059407563,0.09105721,-0.029484786,-0.0802832,-0.063522935,-0.08118036,-0.03666822,0.084503524,0.04954802,0.06902609,0.07265355,-0.031747855,0.020574447,0.023201933,0.05111526,-0.08065713,-0.06618899,0.047063556,0.11532651,-0.03617676,-0.0058953506,0.030006783,-0.016853988,0.08850825,-0.016277302,-0.061480533,0.037205193,-0.038188778,0.030616587,-0.110198356,-0.050425082,0.01316806,0.1339902,0.0046870713,-0.062516406,0.06540801,-0.04880666,-0.01623901,-0.07955813,0.091274455,0.0044279913,-0.05841977,0.039005388,-0.015178724,-2.9852326e-33,0.075373605,0.030231956,0.023401266,-0.09506901,-0.12866826,-0.0028642733,-0.029003976,-0.013665142,0.043448057,-0.019048166,0.0659751,-0.03745745,-0.03079724,-0.09060713,-0.060037117,0.030718053,-0.006492486,0.060797222,-0.027067441,-0.011913587,0.005105366,-0.03259351,-0.02692103,0.15825962,0.05699198,-0.028819215,0.0011157104,0.0061111217,-0.0046466365,0.073673874,-0.0076516224,0.05863793,-0.063943155,0.0012909736,0.011377185,-0.010292,-0.03222418,0.007425039,0.0330451,0.005331536,0.0779771,0.05468394,0.022876319,-0.019616175,-0.04493711,0.07764324,0.011238993,0.07774676,-0.054890245,-0.043228306,-0.006431965,-0.015807796,0.020002503,-0.02777951,0.021412896,0.022063974,0.040234484,0.020482494,0.049490243,-0.04208155,-0.048574828,-0.023366977,0.043319628,0.08347033,0.0795858,0.0048206295,-0.0058051143,-0.021331962,-0.016054021,0.015928632,0.06665986,0.055626065,0.04125786,0.038229126,-0.013294153,0.03909014,0.008455719,-0.039633837,0.048402946,-0.05442632,0.022488626,-0.017618857,0.03431163,-0.06153528,-0.030193483,0.036544375,-0.012743385,0.114555314,0.009203088,0.032109167,-0.014389077,-0.07117779,-0.08947432,-0.03842861,0.08673133,-2.7354389e-08,0.07119974,0.021811659,0.021080457,-0.089424856,-0.10618245,0.032262765,0.022457268,0.0818352,-0.004559604,-0.017044075,0.006542558,-0.06606023,0.03568424,-0.022279786,0.060520846,0.06349863,-0.007562323,0.010514849,-0.019871116,-0.0148412585,-0.084198914,0.018225303,-0.06836294,0.00034421892,0.052499324,-0.013845853,0.004773357,0.053946104,0.03363559,-0.07900636,0.016958857,-0.04821507,-0.046370853,-0.035661444,0.03791121,0.06462207,-0.06748574,-0.027057962,-0.07169947,0.06278931,-0.09626841,-0.04109069,-0.022873297,-0.04973552,-0.021015393,0.048381098,5.4059485e-05,0.048100136,-0.030273924,-0.07178234,-0.0069108214,0.011552742,-0.0433574,-0.084388904,-0.060898565,-0.009475162,-0.080887884,-0.075354315,-0.033420514,-0.064783975,0.020170523,0.051019758,0.12619294,-0.009562723 +2.7.1.156,"In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC 2.7.8.26, adenosylcobinamide-GDP ribazoletransferase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62, adenosylcobinamide-phosphate guanylyltransferase) activities. However, both activities are not required at all times. The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin [4].",384,1.0,0.016582077,-0.035637565,-0.13229966,-0.048378915,-0.02285143,0.03267809,-0.0039706123,0.024593161,0.05758118,0.011591705,0.0056997524,-0.030993683,-0.044781882,0.037198678,-0.00554454,0.027903598,-0.07395782,0.034703188,-0.013216057,-0.06780595,0.015928706,0.070168614,0.0327597,0.006393417,-0.043537937,0.0034485136,0.021820897,0.040164407,-0.0016859033,-0.06307923,0.016942292,-0.031623136,0.09092901,-0.058218792,0.07220405,0.078320324,0.0023242964,-0.08246779,0.06306461,0.049341463,0.054911826,0.059197154,0.031625662,0.027873777,-0.025501993,0.017367674,-0.018718937,0.07563736,0.012027933,0.008657226,-0.02787521,-0.034813,-0.048097685,-0.03648945,0.010953174,0.09502668,-0.07968043,-0.054115407,0.043511048,-0.033944022,0.0042995033,-0.043322187,0.015681628,0.06070413,0.03814673,-0.031401917,0.060753718,-0.07449024,0.03350959,-0.0044655865,-0.041045804,-0.041322842,-0.053843405,-0.010695465,-0.04251316,0.07136274,0.04087416,-0.047193028,0.011233454,-0.054968104,-0.040450614,0.02082231,0.042860813,0.0061350404,0.026296213,-0.04021318,0.014530858,0.049705155,0.044661585,0.074795775,0.042099178,0.009821461,0.12400155,-0.060938433,0.00079515856,-0.020918852,0.09822857,0.08018581,0.019889032,-0.056923404,0.007692855,0.04736213,-0.04730013,-0.05159433,0.06718929,-0.046382878,0.054697957,0.123004764,0.021519585,0.030877246,-0.05332145,0.046690818,0.059529796,-0.028035037,0.0020963044,0.045336403,0.009775106,0.00094415183,-0.010232303,-0.0054244744,0.0014739812,-0.06524581,0.027176103,0.007933916,-0.027237745,0.015181389,-0.07104411,4.9346312e-33,0.042260505,0.034709603,0.034814678,0.018249197,-0.024758114,-0.026351789,-0.07626339,-0.04323668,-0.05341412,0.030647425,-0.06240672,-0.019679725,0.06145154,0.017173052,-0.025523217,-0.075901,-0.068411484,0.020256486,0.015716571,0.11169494,0.003335541,0.041515563,0.014939692,0.07041212,0.011533819,0.012019258,-0.03613169,0.074403666,-0.019444562,0.0004086922,-0.047283784,-0.0064961957,-0.13896762,-0.0039768987,0.051524676,-0.068390824,-0.060301054,-0.01274286,0.02608179,0.10595261,-0.0368496,-0.006360693,-0.06712006,-0.0018508801,0.052382324,-0.060616948,-0.0041982457,0.09170699,0.016770648,0.03590952,0.0015431457,-0.0067768027,0.07784043,-0.022362418,-0.021836538,-0.025057727,0.0003508435,0.008981166,0.036774892,0.09906596,0.013229289,0.072065435,-0.040662214,0.060741004,-0.03132141,0.024141375,-0.025045365,-0.12978774,0.0042600837,-0.002989281,0.035468195,-0.039242215,0.06293859,0.06823428,-0.002447856,-0.004338396,-0.04219612,-0.12672618,-0.018639361,-0.027373634,-0.00058457267,0.0032432266,0.049819067,-0.045579296,-0.013225356,0.015657121,-0.017890206,-0.046464585,-0.07287348,0.011277001,0.038466662,-0.03624789,-0.011207923,-0.026418867,0.047129508,-4.9373415e-33,0.14765607,-0.07414518,0.0042137406,-0.14656611,-0.10119967,0.030930301,0.038705558,-0.13661957,0.08498813,-0.09005313,0.08159959,0.02093548,-0.009078397,-0.009689063,-0.01982785,-0.05903776,0.03712167,0.10089513,-0.04986203,-0.044191577,0.041301854,-0.009504844,-0.03985687,-0.007608259,-0.028117849,0.034238886,-0.0013239756,0.074657895,0.05756603,0.038975645,-0.054450978,0.050250217,-0.04727111,0.00568307,-0.035683297,0.058971666,-0.017846469,-0.013423533,0.025405787,-0.035762534,-0.009895792,0.06557996,-0.030056512,0.024770914,0.03366549,0.06884993,-0.019895924,0.0007156123,-0.05841867,0.0068562757,0.011429947,-0.013797057,0.004008004,0.028799605,-0.018792998,0.06552126,-0.017376475,-0.07259261,0.0450641,-0.076765284,0.0012999282,0.022740139,0.06776396,-0.04263502,0.010286188,0.027825955,0.03183893,0.048812546,0.027831582,0.019280152,-0.021716531,0.04898037,0.031617705,-0.0067492453,-0.050194122,0.018759407,-0.0644317,-0.078675345,0.025951847,-0.09485311,-0.041858446,0.04038971,-0.0020874222,0.006792389,-0.015255758,-0.0010637946,0.02812319,0.045167796,-0.049025483,0.057327744,-0.038359974,-0.0801778,0.0370395,0.09116207,0.040179394,-4.9231097e-08,0.053537045,-0.04950562,0.0032547645,-0.067773476,0.07794249,0.10167686,-0.07066706,-0.052310128,0.13796371,-0.06271493,0.008269717,0.105917886,0.010926948,0.04304589,-0.04066973,0.0827481,-0.049376905,-0.07389261,0.016510759,-0.097120196,-0.08186312,-0.026945876,-0.07163604,0.055771362,0.024881857,-0.05447294,0.031733204,0.09345383,0.014368894,-0.038868126,-0.030438635,-0.024936493,-0.04953073,-0.028768294,0.050205167,-0.018553846,-0.04528603,-0.019720789,-0.012197381,-0.0044471156,0.012807376,-0.012947455,-0.0948083,0.030998772,0.01151432,0.020812456,-0.08011462,0.0708384,-0.043363515,-0.056268074,0.03352227,0.036963675,-0.044488512,0.0013194786,-0.062439457,0.04666517,-0.035959918,-0.08174696,-0.02536702,0.028723944,-0.05682504,0.0034989845,0.082947426,-0.16203117 +2.7.1.157,"The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.",384,0.99999994,-0.0007712899,-0.15559745,-0.021183092,-0.028348044,0.058542646,-0.022048445,-0.032084357,0.046344783,-0.024138438,0.09113273,-0.016313965,-0.0043136976,-0.038853828,0.04303924,-0.029352807,0.0088037,0.0057404637,-0.026736582,0.055890683,0.032287303,0.14331394,-0.023097916,0.03398812,-0.00027591182,0.05823734,-0.06605012,0.08649375,-0.0074530924,-0.0144794425,-0.069246784,-0.002621025,-0.01552353,0.0843589,-0.028426832,-0.089615054,0.11457753,-0.009071526,-0.009995846,-0.0068440274,-0.059794497,-0.043383013,-0.02782004,0.050549287,-0.024517389,0.036969334,-0.06329227,-0.019132873,0.0023672634,0.011972603,0.02951238,0.006014131,-0.082628,-0.0542692,0.019661674,0.049514752,0.038365923,-0.07618799,0.0060249353,0.03661636,0.01437947,0.047410883,0.07220706,-0.06404176,-0.033430163,0.028708622,-0.059424352,0.038774867,-0.023669284,-0.0035476522,-0.020998143,0.016861819,-0.072841726,-0.053949874,-0.05252985,0.00916109,0.035145853,-0.008755755,-0.08233898,0.018764917,-0.014507979,0.019940775,-0.0049831513,0.033649858,0.066577345,0.0024160005,0.024838127,0.025678638,0.008443351,0.04524068,-0.00503252,0.0582277,0.00048503603,-0.081725575,0.018021233,0.00018345419,0.0040834025,-0.0073007215,0.02174026,0.02599125,-0.020565892,0.04131524,0.053683113,-0.041882683,-0.03381323,-0.06685211,0.06667037,0.037730344,0.04777603,0.0027474856,0.026598614,0.027672872,0.010477899,-0.01095819,0.039499443,-0.0956802,0.11853908,0.041079756,-0.13742319,-0.100753374,0.010872076,0.009359795,0.047009517,0.053954568,0.034678858,-0.0257729,0.04436813,-0.037272915,8.064975e-34,0.051283654,0.0042724847,0.04976312,-0.019985015,-0.029944543,0.029677603,-0.07390096,-0.03783699,0.014511654,-0.052491296,-0.110350214,-0.027563885,0.022425897,0.045410473,-0.005176055,0.01985909,0.07701911,-0.050601963,0.07131438,0.027745083,-0.023890294,0.023553964,-0.078658566,-0.038618684,0.11836843,0.067923754,0.080646895,0.036882076,0.04792236,-0.0060248557,0.011358312,-0.10751539,0.0022721104,0.04793801,0.08956393,0.034833204,-0.052780416,-0.016295373,-0.008707401,-0.041455574,0.04579273,-0.0026164898,0.011972879,0.046689022,-0.0012765068,-0.03183158,-0.028650368,0.044223577,-0.009014406,0.08726085,0.06699726,-0.012664533,-0.019726371,0.03559944,-0.050083224,0.077851154,-0.0788554,0.0109573165,0.08987354,0.077017784,0.0056876377,0.01002179,-0.0015284064,0.07784736,0.05134447,0.040151276,-0.12839884,-0.025268879,-0.07351546,0.0591327,-0.09876314,-0.101159535,0.055171933,-0.023037825,0.026037285,-0.00487861,0.009396864,0.008156369,0.009475909,-0.03602564,0.014360651,-0.060564045,-0.014115836,-0.013412856,-0.076324224,0.013620519,-0.033557672,-0.09814933,-0.043858767,0.034020916,0.06526008,-0.004981708,-0.030661268,0.037881542,-0.02321812,-3.582068e-33,0.052169703,-0.073517025,0.08826338,-0.044983517,0.0069592237,0.08450448,0.061474606,-0.15731479,0.03202619,-0.06400309,0.028182656,-0.010142676,-0.07876745,-0.053489927,-0.020683791,0.06412623,-0.015219266,0.07295155,-0.013663138,0.042328525,-0.039689865,0.13014807,0.027591964,-0.023602396,0.036207408,-0.02108949,0.015333881,0.05370742,0.011558897,0.04793854,0.044659495,0.002178291,-0.040613186,-0.06951601,-0.059678357,0.064881384,-0.012741858,-0.01741746,-0.0300152,0.07430112,-0.034667667,0.051212385,-0.02170109,0.029956317,0.014881072,0.032420915,-0.042430535,-0.018333996,0.024522355,-0.051792197,0.059853215,-0.022976555,-0.0026188474,0.016797319,0.06693291,0.029724397,0.053474832,0.05915614,0.008220049,-0.03025011,-0.009788047,-0.028219832,-0.0052325246,-0.09014796,0.060491826,-0.020722555,-0.050904825,0.019092876,0.0017161104,0.0058645587,0.017733173,-0.00025334753,0.017268755,0.051779058,-0.08108394,0.031123634,-0.098577,-0.09720217,0.0054408177,-0.037751976,0.04291829,0.0955234,0.0003892887,-0.02442358,-0.032665715,-0.08724001,-0.0020350514,0.06360437,-0.032948915,0.007209146,-0.07211161,-0.054847497,-0.024396054,-0.004164168,0.0910062,-3.2058853e-08,0.02434115,-0.028585454,-0.03425274,-0.08330001,-0.025598163,0.001661857,-0.003980607,-0.012730806,0.01495391,-0.011171781,-0.04229203,0.102680355,-0.013285726,-0.00232504,0.04715701,-0.037290964,0.01590156,0.058969107,-0.06963311,-0.015594377,-0.050900113,-0.005261853,-0.18472254,-0.02191667,-0.023869596,-0.061480504,0.04148026,0.11049693,-0.03455745,-0.043188773,0.0530926,0.049937204,-0.023064299,-0.051262077,-0.093080595,0.026304422,-0.05234583,0.020504728,-0.016342217,0.017683754,-0.0020044306,-0.03707133,0.011480829,0.017409056,-0.09109542,-0.03959048,0.0070215655,0.010720275,0.0068667587,0.116503626,0.0634459,-0.010671052,-0.050427645,-0.09838219,-0.012155352,-0.023076212,-0.004692908,-0.042403877,-0.033800893,-0.103165954,0.022402566,-0.029906478,0.08434818,-0.04483287 +2.7.2.1,"Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate [4], others have found that the enzyme can also use propanoate as a substrate, but more slowly [7]. Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate [9].",384,1.0,-0.10419052,-0.053348027,-0.09214222,0.030723091,0.049553774,0.030147443,-0.09198785,-0.029853227,-0.073324755,0.003330324,0.024001092,-0.055029873,-0.079153284,-0.009853557,0.0020594848,0.005302072,0.024055744,0.067337744,0.057422467,-0.038429406,0.092596844,-0.03227818,-0.076808535,-0.0050735255,0.07490573,0.026877915,0.06749565,-0.008730522,-0.0010302737,-0.02957113,-0.0588365,-0.07128034,0.05322908,-0.046578668,0.053452957,0.0752973,-0.0580984,-0.060770877,0.021287655,-0.021303743,0.056067932,-0.03748453,0.04279736,-0.036905937,0.045119386,-0.06660216,0.07392422,-0.00046362935,0.017108962,-0.060083248,-0.09189626,-0.005024438,-0.053761993,-0.013542068,0.00407347,-0.01511793,-0.010923917,-0.0362367,0.030340025,0.012511336,0.03269902,-0.01676105,-0.05784951,-0.043984905,-0.008630169,-0.08647986,0.07606541,-0.057591457,0.055736285,-0.033182256,-0.03971574,-0.019592425,0.035265576,0.062387973,-0.0024716726,-0.004958606,-0.010566219,-0.06729325,0.05845497,0.017311744,0.023797307,-0.04693555,-0.020291533,0.013783727,0.003729645,0.033794455,-0.0092029525,0.043472268,-0.027367147,0.06105449,0.0553466,0.03379263,0.078799345,-0.091475755,-0.03260351,0.03181739,0.0060663465,-0.0060805692,0.059342727,-0.022199739,-0.015598165,0.13676235,-0.017669749,-0.036834527,-0.017599413,0.017321592,0.0065367417,0.12666397,0.032407638,0.11379741,0.045337636,-0.002121669,0.030406378,0.022427484,-0.0072252327,0.10891667,-0.09562871,-0.1427876,-0.00697256,0.08392883,0.0027245455,-0.034833293,0.026444249,0.08642851,0.0034667698,0.021915294,-0.014710431,3.9442953e-33,0.037370253,0.0371047,0.035280034,-0.02318159,-0.008601439,-0.036075696,-0.04373903,-0.09484386,0.024625605,-0.0818779,-0.0035666341,-0.06592308,0.01381656,0.07600295,-0.046907872,-0.048271064,0.012773528,0.013720438,0.05634621,0.043127056,-0.028606711,0.010459167,0.0066635134,-0.0040573943,0.003095307,0.014690513,-0.029058391,0.052688703,0.024554903,0.017282499,-0.0042441185,-0.05771559,-0.054520078,0.022857593,0.07300696,-0.09086022,-0.024188275,-0.08458628,-0.008398639,0.07822773,0.026481342,0.045171842,-0.014390385,0.061484557,0.013369554,-0.04038861,-0.0024986987,0.12115754,-0.0030896964,0.03469251,0.05999523,0.00022047124,0.050605793,-0.061021764,-0.013074386,0.045103412,-0.025070619,-0.021751387,0.1174899,-0.047056124,-0.04893404,0.067597315,-0.0032781698,0.11734285,-0.012287837,0.05296126,-0.089496225,-0.060435466,0.04011355,0.06589691,-0.019430194,-0.049583077,0.026524907,0.016786695,0.011578962,-0.049762346,-0.026028156,0.030477254,-0.006748581,-0.01439801,0.029841103,0.03215191,-0.02962742,0.041263115,-0.038262025,-0.006085373,-0.018082539,-0.03619578,0.05260112,0.057181608,0.0507793,-0.044680234,0.0062004197,0.06366983,0.009112591,-4.027468e-33,0.109895155,-0.065491624,0.064677864,-0.0805115,-0.1577865,0.08799989,0.033864655,-0.09827165,0.047059465,-0.013981829,0.07341174,0.010572379,0.060516156,-0.067229696,-0.03293589,-0.045766156,-0.0030923046,0.047553953,-0.035404515,-0.0008693043,0.043769356,0.019865738,0.02877776,0.02657192,0.04353312,-0.02530134,-0.076527566,0.056685023,-0.01258511,0.01633025,0.018025272,-0.011148861,-0.048156317,-0.05782228,-0.09107761,0.04448651,-0.0075424416,0.027419664,-0.026900077,0.016647477,-0.019905766,0.061268426,-0.029522646,0.047515575,-0.016724832,0.008789892,0.07110671,-1.2510107e-05,0.017116448,-0.107493915,0.029957607,-0.017285304,-0.107725024,-0.037772115,0.024584971,0.050146874,-0.011155377,0.035166126,0.02958789,-0.07438273,-0.038501937,-0.10934125,0.08742278,-0.055573896,0.09625692,0.042451568,-0.013646879,0.073125206,0.028054336,0.048952233,0.027726566,0.041910138,0.10583227,0.08692246,0.04267666,-0.0029823154,-0.032839194,-0.045883693,-0.04999906,-0.047090765,-0.022314422,0.032792643,-0.08099546,-0.043645382,-0.07194893,-0.023959598,0.0298616,0.04844499,-0.0044124112,0.02673169,-0.09108069,-0.051152274,-0.05457704,0.055506542,-0.0004291162,-4.1538076e-08,0.011438486,-0.023112606,0.101528145,-0.029678108,-0.017531,0.05284176,0.019789526,-0.029436482,0.11269302,-0.05551201,-0.060359392,0.07005904,0.074640594,-0.0078583555,6.598312e-05,-0.011482899,0.026473625,0.008803146,-0.0248273,-0.04372651,-0.021981386,-0.08213335,-0.0787265,0.04379585,0.049000986,-0.060949273,0.012630533,0.11125666,-0.0618932,-0.0099059595,-0.025005862,-0.04063797,0.0038017724,-0.038399093,-0.010316732,-0.0059133745,0.0077183032,0.010586169,-0.03318055,-0.015861956,0.0038649028,-0.012876841,-0.07645017,0.033220727,-0.044964,0.0049698376,0.021122599,0.030218137,-0.048455507,-0.0229625,0.06441084,-0.072254635,-0.04743245,-0.07911948,-0.0018289521,-0.02179634,0.03611356,-0.032878775,-0.013148924,-0.037756126,0.09238147,0.023302555,0.11566795,-0.034178823 +2.7.2.2,"The enzyme catalyses the reversible conversion of carbamoyl phosphate and ADP to ATP and carbamate, which hydrolyses to ammonia and hydrogencarbonate. The physiological role of the enzyme is to generate ATP. ",384,1.0,-0.064826,0.073278494,-0.010843537,0.01637213,-0.033429794,0.03524962,-0.026173627,-0.029215397,-0.04303171,0.025293937,-0.062176883,-0.04996571,-0.097672805,-0.0066030873,-0.02980845,-0.026440078,-0.040575758,0.075988665,0.034750476,-0.02619742,0.058760542,-0.0075317775,-0.050416943,-0.044607036,0.058656383,0.059907213,0.06951563,0.022613969,-0.040274095,-0.024024365,-0.038167585,-0.08331235,0.0032210222,-0.082180835,-0.006645326,0.111224145,-0.05604131,-0.02964799,0.061672404,0.00202194,0.06125229,0.021241937,-0.05948968,-0.034281723,-0.04002695,-0.043648098,0.032030072,0.05928563,-0.029812234,-0.057337467,-0.044413235,0.029697811,-0.054087598,-0.037949283,-0.039326012,0.06132288,-0.027449815,0.022994576,-0.049600344,-0.029019404,-0.032059263,-0.00064088986,-0.011955681,0.014514708,0.10016982,-0.097017854,0.025053121,-0.033513285,0.0007166668,-0.005165004,-0.094333336,-0.050239574,-0.042944208,0.0006204877,-0.019296411,-0.03674427,-0.08147282,0.03898572,0.09216067,-0.01418897,0.1084468,-0.008238336,0.009151934,0.07262802,0.035779312,-0.020842586,0.013806237,0.0049799774,0.06616379,0.022294974,-0.01744915,-0.05709167,0.036562562,-0.025871903,-0.05816647,-0.0068994993,0.04703868,0.0047723223,0.0796905,-0.046924785,0.06571066,0.099636726,0.018202124,-0.08848734,-0.033956148,0.0784745,-0.05276924,0.10151208,0.0693017,0.04655698,-0.045588173,0.08790883,0.06255037,-0.01220363,0.015206391,0.080926135,-0.058986053,-0.04441979,-0.033484366,0.04495588,-0.007872205,-0.07448957,0.015442119,0.053834133,0.0022457815,0.035329282,-0.0651656,5.558226e-34,0.008803713,-0.031670745,0.037264917,-0.013621941,0.026310364,0.00095569086,-0.052938458,0.017998368,-0.029126778,-0.05639229,-0.021679925,-0.04254464,0.06146167,0.022256086,-0.048125878,-0.009591357,-0.08835117,0.06562863,0.077194005,0.030722303,0.009133302,0.047303088,-0.05521572,0.018417438,-0.020810338,0.061569575,-0.04490501,0.017289845,-0.031920735,-0.0048226197,0.030910695,-0.11411763,-0.15049022,-0.034703024,0.010314006,-0.021212498,-0.04442861,-0.075237095,0.009699572,-0.0009155328,-0.019913951,-0.033465523,0.0023060516,-0.003766039,-0.005027796,0.014824313,-0.007394417,0.070433214,0.020896014,0.061743695,0.066511475,-0.082590245,0.060791846,-0.054050405,-0.062065642,0.04676827,-0.0031420514,-0.011459561,-0.028018858,0.055228338,0.049230624,0.03918534,-0.019840926,0.051801175,-0.029892653,0.013248268,-0.005724282,-0.09255609,0.068559766,0.08408322,-0.093333006,0.008311382,0.049686696,0.011843723,-0.033456538,0.021492431,0.023593655,-0.010451888,0.00986713,0.036123294,-0.012121291,-0.064062454,0.038345687,-0.07000254,0.036190845,-0.08206877,-0.020830182,-0.09560079,-0.030595634,0.052268308,0.13034339,-0.06940809,-0.07441873,0.058556017,0.020407584,-3.1089963e-33,0.10924783,-0.04545059,0.00084538595,-0.09950938,-0.07645292,-0.0071425997,0.030174842,-0.057130855,0.0015692371,-0.031745646,0.009000987,-0.03345576,0.09981209,0.018079313,-0.006372043,-0.00875933,-0.01313104,0.058454063,-0.0056249374,0.0058436845,0.0032471658,0.12562907,0.051895674,-0.0013851867,0.027754499,-0.014653038,-0.032325882,0.08617998,0.110788934,0.023751257,0.075118355,-0.027425323,-0.036921147,-0.033460584,-0.045845807,0.056265935,-0.04532965,0.031317618,0.06508346,0.013298162,0.046522558,0.028402325,0.0063542794,-0.009252907,-0.017693711,0.08108476,-0.034631483,-0.0041403957,-0.025184564,-0.07644804,0.07107738,0.058411907,-0.009312471,0.022142371,-0.006783858,0.058085404,0.042789213,-0.042254448,0.03600033,0.025545886,-0.0664235,-0.040727306,0.10417639,0.010513183,-0.035383295,0.039401446,-0.0012089547,0.0062630307,-0.0026102369,0.01388358,0.053398814,0.023805585,0.039721306,0.08244102,0.021195464,0.057106074,-0.061175376,0.016808337,-0.021150677,-0.095077746,-0.0012738311,0.030547552,-0.05219727,-0.063914485,-0.08165258,-0.06158462,-0.0064751585,0.07897366,0.024690174,0.052241147,0.020004828,-0.021852767,-0.03182037,0.047419246,0.047845133,-2.9070561e-08,-0.019316724,-0.05030073,0.09512578,-0.0600206,-0.023434259,0.0847222,0.039904006,-0.010501901,0.051578093,-0.05509515,-0.00017629871,0.03733904,0.021015795,0.029422212,0.046620663,0.028145114,-0.056412805,0.006880577,-0.050303955,-0.078020506,-0.061439488,-0.044676367,-0.11735539,0.112485304,0.09450416,-0.012152258,0.004679587,0.016579166,-0.008573464,-0.017173942,0.00741805,0.02182687,0.034112312,0.016766518,-0.05470025,0.018709728,-0.05079738,-0.043646757,-0.059458986,-0.03613275,-0.017311728,-0.0523835,-0.09295616,0.012253082,0.015893089,0.056463126,0.006765991,0.026130227,-0.037824992,-0.012557582,0.027232429,-0.041392528,-0.029382667,-0.121282056,-0.059841815,0.03749796,-0.055196274,-0.015275543,-0.011859644,0.0073514027,0.016536683,0.12945564,0.15124686,-0.07192144 +2.7.2.4,"The enzyme from Escherichia coli is a multifunctional protein, which also catalyses the reaction of EC 1.1.1.3 homoserine dehydrogenase. This is also the case for two of the four isoenzymes in Arabidopsis thaliana. The equilibrium constant strongly favours the reaction from right to left, i.e. the non-physiological direction of reaction.",384,1.0,-0.0581237,-0.04338669,-0.0620912,-0.0034797236,0.014473956,0.056062065,-0.096207134,0.030664897,0.059058357,-0.00494403,0.08196104,-0.08938664,-0.081745535,-0.0299325,0.032147292,-0.003529982,-0.0677205,0.031670295,-0.031758342,-0.1207131,0.05117061,0.037403315,-0.046798248,0.0024849998,-0.001426171,-0.02605874,-0.018710956,-0.0005040143,-0.03334797,-0.09740917,-0.002692048,-0.05498989,0.059353292,0.0070904396,-0.0007450698,0.09430215,-0.036460288,-0.18144585,0.07105807,0.014900069,0.009186958,0.066401005,-0.04661067,-0.070611574,-0.09330861,-0.022842245,0.028834254,0.047167208,0.048968296,-0.065948986,-0.017523207,-0.035682175,-0.03231829,-0.0020399494,0.026891943,0.007084144,-0.0017919873,-0.006556106,-0.0274148,-0.01254257,0.073826596,-0.026602373,0.02656721,0.0037630505,0.064735666,-0.076854736,0.061492953,-0.080261126,0.02622841,-0.014918484,-0.063489884,-0.08351954,-0.034938686,0.000119232354,-0.015929881,0.03186143,-0.07156557,0.013098483,0.018502455,-0.00723793,0.031168662,-0.057520464,-0.00652354,0.030252723,0.009214469,-0.06305609,-0.0049924436,0.008608804,0.11633659,0.03343667,-0.006838809,-0.0027436414,0.022670146,-0.023798432,-0.009730726,0.06330809,0.01861002,0.044206556,-0.0043804795,-0.03481238,0.009159566,0.09750942,-0.018119032,0.0056780353,0.03266916,0.004795212,0.0049973717,0.08378286,-0.04790362,-0.020360574,-0.018036641,-0.052999146,0.07594602,0.0636701,-0.017604517,0.010876463,0.026456682,-0.039693777,-0.0195942,-0.024473105,0.028727079,-0.06697944,0.018770745,0.055815242,-0.04633908,0.052153464,-0.1366193,1.5133838e-33,0.058022022,0.0050653266,-0.0155201545,-0.043008,0.0021418736,-0.029505558,-0.06933015,0.1050878,-0.070024475,0.0021777307,-0.039855294,-0.0066833184,0.09773419,-0.005274176,-0.07528447,-0.035530515,-0.07361095,0.012371585,0.064192265,0.06441465,0.0016828274,-0.01149781,-0.04850446,0.017033909,-0.0063139154,0.042855904,-0.00853824,-0.020831415,-0.017619625,-0.029841736,-0.01612587,-0.077424884,-0.057240635,-0.00091241155,0.08132709,-0.07572407,0.0007056133,0.0058849985,-0.021129193,0.041202683,-0.06812686,0.029785743,-0.011334762,-0.08051609,0.100169204,0.027708776,-0.038358822,0.068877295,0.029115908,0.061375644,0.03544457,0.013906439,0.16000228,-0.13143583,-0.012911657,0.029754864,0.009059266,0.056326084,0.0014070083,0.101051755,-0.0797841,0.09059254,-0.028341636,0.00601078,-0.0045073256,0.0734244,-0.087835774,-0.08573173,0.048649557,0.11379623,-0.07331012,0.001797478,0.064970866,-0.012151273,0.0005580806,-0.0012221829,-0.10074865,-0.023185974,0.007611468,0.057117086,-0.042364154,0.040402327,-0.012796518,-0.0151000535,-0.02375588,-0.036085173,-0.062301334,-0.009468056,0.008659132,0.1172159,0.06945853,-0.0118442075,0.00038091897,0.049068425,0.0894354,-2.7131473e-33,0.06654984,-0.079555616,-0.053665712,-0.100021794,-0.068859465,0.15129878,0.01072212,-0.02141878,0.05317863,0.047253873,0.06972106,0.017337868,0.013014762,-0.034519974,0.042582646,0.03953874,-0.022270527,0.03719724,-0.0030960345,0.018215755,-0.0003514077,0.06792545,0.007141443,0.050880346,0.0661186,0.025764566,0.0053943144,0.08686784,-0.01302631,0.019278819,-0.019630324,-0.059990745,0.020214267,-0.01868868,-0.04335653,0.05487535,-0.07430703,0.022471512,0.1118298,0.032442912,0.0022605418,0.038282506,0.02213216,0.09627031,0.04062129,0.019110698,-0.061828934,0.0067465235,-0.039819747,-0.022392673,-0.034586683,0.0072812447,-0.047565103,-0.03169504,-0.0027836722,0.014452639,-0.02535365,0.04088462,-0.0045456784,0.017261378,-0.010855788,-0.06696971,0.06427206,0.043725133,-0.015966568,0.008416254,-0.05630903,-0.013676547,0.025418175,0.01786301,0.09648325,0.010375848,-0.01679861,0.024390722,0.04958376,-0.023544123,-0.06976344,-0.05058193,-0.04846317,0.0030497068,-0.029338418,0.042912528,-0.010033228,-0.062479835,-0.004752369,-0.09365331,0.03377986,0.12093215,0.02429243,0.036815442,-0.0042558443,-0.026443051,-0.03143587,0.01757162,0.05791523,-4.323564e-08,0.010549282,-0.045265283,0.08349213,-0.028165499,0.0169482,0.0815262,0.028854571,-0.016276184,0.04216304,0.012902917,0.014120811,0.067065395,0.014239817,0.046760444,0.061885048,-0.035879694,-0.068045534,-0.003870625,-0.01599035,0.01699929,-0.0015317303,-0.026836868,-0.1048134,0.008221672,0.021908721,-0.04706701,0.020497844,-0.001135672,-0.032253414,-0.019727493,-0.014876548,-0.0014989133,0.004961043,-0.04897599,-0.04387082,-0.038388852,0.0140654035,-0.010645967,-0.041172195,-0.025121786,-0.009184823,0.006585201,-0.11963269,-0.0017779699,0.03224367,0.110986084,0.04703413,0.002629255,0.0019448512,0.041390587,0.05964451,-0.04277414,0.026313026,0.0042327275,-0.076240376,-0.050709516,-0.038581986,-0.088125564,-0.040908996,0.016281873,0.03877411,0.027330587,0.16729778,-0.058858287 +2.7.2.7,"The enzyme from Clostridium sp. also acts, more slowly, on pentanoate and propanoate, and on some branched-chain fatty acids (cf. EC 2.7.1.14 sedoheptulokinase).",384,0.99999994,0.013362426,-0.08766734,-0.03121065,-0.00525456,0.073872134,-0.016721737,-0.08510866,0.034358412,0.0854154,-0.036488406,0.06428833,-0.033751134,0.0003678959,0.10464203,0.005035084,-0.027260927,0.008098223,0.0036008018,0.05647357,-0.012268323,0.10585031,0.039390482,0.008588449,0.0018263191,0.0017023382,-0.017389797,0.039016504,-0.010948115,-0.011650275,-0.075256705,-0.04329702,-0.06652756,0.026903756,-0.06884525,0.08075456,0.07725177,-0.03769378,0.016129859,0.10328869,0.06896556,0.053774267,-0.053380225,-0.01317485,-0.06279196,-0.038818136,0.0014508823,0.0004996703,0.03879948,-0.017402992,0.010654576,-0.07565222,-0.10471373,-0.031061444,-0.001711885,0.04342384,-0.022614175,-0.04080965,-0.0083665615,0.02682192,-0.013036753,0.0062960475,0.016383767,0.019652849,0.019679263,0.011013697,-0.11549796,0.06467685,-0.05979848,0.0010828989,-0.02106231,-0.0042205113,0.02361158,-0.004926185,-0.014461308,0.037887145,-0.024216684,-0.07223155,-0.09212809,0.003221017,-0.09102017,0.015472576,-0.036298845,-0.032099314,0.025708668,0.0064794193,-0.008316627,0.08558402,-0.008953182,-0.040601004,0.034508437,0.1086585,0.05846562,-0.04182134,-0.057847522,-0.021049937,0.048864152,-0.035806466,0.040828828,-0.0029517591,-0.032643937,-0.049871005,0.032571897,-0.03548561,-0.074912384,-0.05189225,-0.031362537,0.016991185,0.06558171,0.003489043,0.0057089245,0.041966468,0.012503484,0.09638874,0.050147578,0.013662928,0.023813063,0.0422392,-0.041867338,-0.04644928,0.061941072,-0.012354868,-0.050799422,-0.0015164737,0.06147315,-0.015429832,0.13124046,-0.028293762,2.2889462e-34,0.03745886,0.0044615674,0.01897715,-0.0865553,-0.004320536,-0.018330123,-0.06270072,0.005562538,-0.05844395,-0.0262127,0.012012375,-0.0981581,0.030718565,0.07301075,-0.022926766,-0.06477951,0.032919053,0.05317336,0.018040981,-0.038412586,0.07114943,0.057866964,0.007867212,-0.01932214,0.06986484,-0.015559907,-0.03949575,0.020050772,0.006672727,-0.02090491,0.058731325,-0.056076735,-0.081093974,-0.03145873,0.11577282,-0.017815407,0.04076722,-0.0856466,-0.06656971,-0.012251249,-0.02670216,0.0024345138,-0.035138022,-0.03935082,-0.012928724,0.0010993651,-0.067688115,0.13157919,0.037928764,0.054604635,0.11358905,-0.007336322,0.046770114,-0.09931143,-0.036290478,0.037823036,-0.0149648525,-0.024220372,0.05629683,0.014685562,0.005296874,0.06726621,-0.08020159,-0.022013415,-0.0013665743,-0.012339881,-0.06669212,-0.043828186,0.049839202,0.0066455784,-0.030710625,-0.036919277,-0.03217748,-0.0106247235,0.03571384,-0.03190076,-0.1260262,-0.09125413,0.02280558,-0.008763079,-0.06826372,-0.013590152,0.0063830996,-0.03152243,-0.035441842,-0.036752935,-0.07943196,-0.0076308046,0.037815314,0.017555574,0.013997035,-0.0907012,-0.07688164,0.045875877,-0.011420004,-1.6666813e-33,0.0660911,-0.123188585,0.061126955,0.010266675,-0.03495169,0.057450112,-0.04608692,0.0451331,0.007600998,-0.08470092,0.06025641,0.008453262,0.011040913,0.0019744101,0.033119474,0.06788427,0.012686429,0.074238904,0.0047328016,-0.037931874,-0.008642361,0.047507223,0.040383887,0.15464962,0.051617693,0.08151471,0.006477127,0.104022115,0.021761041,0.054486226,-0.006042034,0.023585165,-0.032141894,-0.023838567,-0.084944464,0.09529686,-0.047426388,-0.026005432,0.036866125,-0.0032883615,0.01704745,0.018447457,0.029001012,0.009874864,0.013438572,0.008697967,0.0021377825,0.026136009,0.026774533,-0.032933433,0.0003666654,0.02233126,0.026076283,-0.020298319,0.036823988,0.011648864,-0.047936942,-0.031604823,-0.008356933,-0.10874736,-0.06952227,-0.05590687,0.008159327,0.028826501,0.052868165,0.028284516,-0.027178384,-0.014045267,0.07221885,-0.07227908,-0.0028919773,0.038172517,-0.017425666,0.0059012333,-0.06260253,-0.021878729,-0.025844118,-0.021041421,0.017204426,0.027020492,0.0030166372,0.02520115,-0.017989045,-0.10363302,-0.06806684,-0.0066561354,-0.0077019543,0.036854774,0.020028949,0.080236435,-0.058014397,-0.026007477,0.015070952,0.0513182,0.047753207,-3.6444185e-08,0.04461143,-0.037848685,0.19826363,-0.023613926,0.024716811,-0.024010804,0.076385275,0.022406548,0.038074806,-0.04504421,-0.013287048,0.09552242,0.085685864,0.021368315,0.06314503,0.04985333,-0.032485995,-0.032974295,-0.014894871,-0.042705692,-0.085359655,-0.06267004,-0.08496975,0.08336456,0.028537394,-0.051854815,0.012069204,0.076773435,-0.01987604,-0.0030459655,0.019798169,0.011622329,-0.0037291246,-0.021864248,-0.020485118,0.032911625,-0.034058098,-0.035125103,-0.022645913,0.08581817,0.026723797,-0.04510501,-0.09038704,-0.052160952,-0.043376543,-0.03252897,-0.042941112,0.007073217,-0.01956698,-0.0423127,0.06066815,-0.034494508,-0.061826527,0.054652624,-0.00294338,-0.0070666336,0.019355582,-0.07251245,-0.0019850214,-0.037483443,0.00092422764,0.010590883,0.23925625,-0.012256444 +2.7.2.11,"In the absence of downstream enzymes, the product rapidly cyclizes to 5-oxo-L-proline and phosphate.",384,1.0,-0.108308636,-0.10841718,-0.0272186,-0.010185297,0.10691822,-0.0278226,-0.041912932,0.0613679,0.021086073,0.03672553,0.043433413,0.08968958,-0.009428896,0.025541143,-0.0704703,0.084209725,-0.088268645,-0.033967793,-0.09811484,-0.05246101,0.09787527,-0.016649926,-0.036732327,0.04033675,0.036057595,-0.02600502,0.04190022,0.045892574,-0.074340306,-0.07936373,-0.059334368,0.017419714,0.035346866,-0.062438093,0.05725915,0.07430098,-0.05542422,-0.013712294,0.028315203,0.009645733,0.061467342,-0.0869699,-0.07760456,-0.04945355,-0.0008430684,-0.04205316,-0.012950632,-0.003963297,0.07086645,-0.014320954,-0.10210963,-0.08667684,-0.116610624,-0.002444476,-0.07097635,-0.0366139,-0.057924666,0.030773217,-0.04212102,-0.02880937,-0.036499128,0.024583055,0.0020673482,0.058470033,-0.004268612,0.012619853,0.0168155,-0.022944633,-0.050170466,0.037341423,-0.039437313,-0.068690225,0.027863868,0.024407906,-0.025503594,0.0020143099,-0.0027217446,-0.0793335,-0.02161983,-0.00870878,0.04690855,0.06845689,0.0056587746,0.03485375,-0.011612863,0.02349074,0.011026794,0.009753395,0.04090533,-0.017561372,-0.018957185,0.01729366,-0.02785605,0.027950915,-0.031703312,0.01793799,0.030949658,-0.03888481,-0.019557992,-0.021392645,0.016242493,0.036756594,0.042154286,-0.089205824,0.0014217456,0.069436096,0.003884533,0.06721288,-0.0010857227,0.009988022,0.022066066,-0.028670602,0.0051722066,0.025810134,0.002599332,0.0867632,-0.02443964,-0.033791576,-0.055552457,-6.59905e-05,0.009146683,0.01861516,0.017428257,0.04046834,-0.08380942,0.09857414,-0.042772647,-2.2543256e-33,0.010543952,-0.0019484026,0.028639011,0.046289664,-0.026083587,0.017053796,-0.075890556,-0.026415326,-0.039999526,-0.0043643047,-0.07436652,-0.08378929,0.08988441,-0.06969064,-0.0066132364,-0.026759546,-0.0008685001,0.06546679,0.013599106,0.07179629,-0.00922721,0.03028473,-0.060981154,0.044510353,-0.009939082,0.027532488,0.018630065,-0.046342805,0.017691145,-0.010844597,-0.0055555464,-0.09933645,-0.04775959,-0.024330348,0.04153054,-0.007442207,-0.02874966,-0.035701152,0.0535405,0.05684137,0.024776207,-0.013951388,-0.028398223,0.029309934,0.060771838,-0.07538611,-0.06814394,0.13235089,-0.0075866133,0.06731347,0.020987395,-0.020991119,0.06667296,-0.00855969,-0.06936103,0.021791847,-0.08336373,-0.013657671,0.051304873,0.03487123,0.013928366,0.04286753,-0.055828765,0.049135905,0.0012727838,0.02955928,-0.06989587,-0.015849,-0.015311802,0.11340792,-0.042790465,-0.005443756,0.11734689,0.014763852,0.07550777,-0.006487116,0.010809711,0.0021034481,0.046513993,0.06897005,0.040494293,-0.010513838,-0.0064806947,0.0041856426,-0.005969804,-0.022367502,0.00563409,-0.079487376,-0.024012389,0.065034024,0.116646476,-0.1185577,-0.050616775,-0.0059274,-0.05142544,-7.7937076e-36,0.13578117,-0.10222451,0.085433684,-0.07364271,-0.05719813,0.012014389,-0.035089564,-0.03719286,-0.0033172243,0.031049656,0.03348939,0.045626286,0.03485864,-0.048845477,-0.01204971,0.028995993,0.0300449,0.11821803,0.08100256,0.022434099,0.0805197,-0.00565774,0.033311065,0.027139492,0.058735676,0.01603871,0.004940415,0.008148734,0.067529805,0.031054173,0.006214008,0.052541345,-0.067452155,-0.104856186,-0.020838939,0.08472207,-0.11061708,0.0067700665,0.051247757,0.007325599,-0.07338236,-0.019072276,0.047118396,-0.06552277,0.016142208,0.035716783,-0.024864016,0.013342398,-0.014260315,-0.0075860834,0.03580437,0.04140555,-0.06320965,-0.012252933,-0.016053108,0.06931163,-0.0010077773,0.085658446,-0.030687466,-0.03764275,-0.013983283,-0.06598369,0.028104257,-0.011644763,-0.005952583,0.08635491,0.067050695,0.030925998,0.012510072,0.010919725,0.05427637,0.049885113,-0.032592423,-0.010184836,-0.047382977,0.0018529582,-0.04002455,-0.022568984,-0.006460586,-0.036176763,-0.011636051,-0.007106391,0.017474838,-0.09096741,-0.043117225,-0.05908178,0.006558153,0.11164657,0.048069097,0.023893429,0.019173171,-0.069541134,-0.057818227,0.04665185,0.10959998,-2.810357e-08,0.030902574,-0.04248994,0.079591475,-0.013853676,0.024948874,0.04377189,0.02804276,0.018958181,0.11172098,-0.012821665,-0.009578032,0.06962306,-0.018431138,-0.013994473,0.056825012,0.028937025,-0.065917455,0.0129088,-0.0049362243,0.003549866,-0.050082956,-0.024551224,-0.07744356,0.044880908,-0.006826711,-0.1035449,0.067628495,0.056926887,-0.049282257,-0.09016264,0.024920624,0.04024585,-0.006407404,-0.0830245,-0.020925077,-0.011843223,0.022243604,0.027892454,-0.0569663,0.030399239,-0.09395232,-0.082459934,-0.019301418,-0.012924139,0.00635564,0.0053501744,-0.020907285,0.005085503,0.036899146,-0.030861786,0.0039143013,-0.013594585,-0.036349513,-0.07499064,-0.055843893,0.06313455,0.059576813,-0.04801902,-0.01365015,-0.053039953,-0.04153037,0.03595261,0.20108399,-0.08701825 +2.7.2.14,"3-Methylbutanoate, 2-methylbutanoate, pentanoate, butanoate and propanoate can also act as acceptors (cf. EC 2.7.2.7 butyrate kinase).",384,1.0,-0.057407826,-0.08108669,-0.09405791,-0.045686193,0.05487554,0.0011603578,0.008245611,-0.047992773,-0.005067073,-0.009867205,0.06624673,-0.07587872,-0.08301155,0.06091844,0.00019258032,0.13519022,-0.079309,0.060076617,0.018689577,0.054339644,-0.00841382,0.014102575,-0.037815284,0.008398009,-0.015143868,0.026245166,0.017373275,0.054435696,0.041075855,-0.12793237,-0.10298035,-0.0106474925,0.0051555354,-0.0036759397,0.007002069,0.058280367,-0.1176384,-0.04571748,-0.054442994,0.023138259,0.063536756,-0.08465099,0.0410034,-0.015856272,-0.0077780527,-0.036536694,0.03684333,0.0020233458,0.082873784,-0.04676413,-0.019477915,-0.02716186,-0.021673292,0.089935206,0.009093155,0.011945677,-0.07377318,0.041045677,0.037483864,-0.024688073,0.045109488,-0.017225612,-0.045028776,-0.035987683,-0.015416319,0.018282766,0.0036285662,-0.009555693,0.018384825,-0.0038868166,-0.0330791,-0.041305486,-0.010150193,0.061457828,0.051124576,0.061310653,-0.02881684,0.009864468,0.054114234,-0.021037199,0.02033636,-0.028013462,0.027824646,0.005136121,0.024511995,-0.028545434,-0.08748927,0.078871936,0.010657509,0.011606403,0.014380605,0.03967622,0.015935654,-0.08581311,-0.020089572,0.008141367,0.07205006,0.032630824,0.03252065,0.012242787,-0.019780202,0.008177977,-0.09784239,-0.020302234,-0.017302915,-0.010610586,0.01674812,-0.02725316,0.010669354,0.02559787,-0.077733085,-0.075906225,0.074567646,0.051949512,-0.04680288,0.041218664,-0.016939888,-0.08810935,0.020748233,-0.005543664,-0.01924148,0.023449665,0.027499452,0.023155672,-0.049326133,0.01791786,-0.094394445,1.9169279e-33,0.02182798,0.03915392,0.05549252,-0.019072618,0.0031108202,-0.020143816,-0.030444082,-0.075939246,0.01548216,-0.123555586,-0.027577527,-0.054331295,0.03883523,0.08715129,-0.044262584,-0.081457175,0.051424913,0.043838706,-0.004257418,-0.06490177,-0.0045830016,0.09007203,-0.11203949,-0.06162313,-0.021289062,0.009357064,-0.014821727,0.046001174,0.056549184,-0.016930694,0.06022222,-0.022512225,-0.02429077,0.028745646,0.043602344,0.001564482,0.0058811796,-0.03926697,0.013915343,0.011952446,-0.013904174,0.01313164,-0.101609305,0.03949003,0.010837705,-0.0025730699,-0.029625805,0.033659253,0.028453475,-0.021602867,0.033246443,-0.031020937,-0.08894449,-0.07153994,-0.005161544,-0.036512498,-0.04179696,0.002569509,-0.028947365,-0.012362439,-0.08810397,0.0015631818,-0.026616126,0.04054173,-0.049223762,0.021009078,-0.12318143,-0.067627065,0.010273126,0.0046264175,-0.0157455,-0.02162756,0.060794342,0.03885115,-0.007109258,0.0026787042,-0.028429605,-0.0045656115,-0.031460073,0.0089387745,-0.047446016,-0.055590104,-0.035173535,0.05418925,-0.14406995,-0.0437529,0.015457803,-0.10478222,0.051575497,0.017929267,-0.0016693837,-0.033020623,-0.041881487,0.00033505395,0.057141855,-3.5622173e-33,0.07296769,-0.012035415,0.09187029,0.012126065,0.0344164,0.1391839,0.08854913,-0.07004141,0.09062145,-0.071650006,0.059294064,0.04162391,0.05395326,-0.03387926,0.049178097,0.038797047,-0.0019639228,0.114736095,-0.0048139,-0.022523247,0.01943641,0.0062580896,-0.042119917,0.11541863,-0.03134673,0.057932924,-0.012423202,-0.044228967,0.00867947,0.093359284,-0.02036952,-0.0037098813,-0.031683676,-0.034838315,0.04700312,0.0070908167,-0.037119735,-0.029783143,-0.13287301,-0.027376842,-0.021224901,0.0055362014,-0.016060155,0.094949126,0.009337103,0.019286126,0.088767484,0.00835236,0.036546845,-0.09763057,0.0014956916,0.0035600786,0.002320439,0.04232214,0.056274,0.07648911,0.07804007,-0.028887445,0.056448724,-0.019879615,-0.030421285,-0.048459735,0.06744855,-0.078016296,0.057465386,0.0004625617,0.006493908,0.007165261,0.05318865,0.000854401,0.11903674,-0.023027487,0.081443645,0.07395018,-0.02980522,-0.016040951,-0.043371428,-0.058262233,-0.061456468,-0.04069869,-0.064104185,0.047547057,0.005885438,-0.009226519,-0.01809177,-0.007724011,0.056094922,0.004067666,-0.041634392,0.023441128,-0.0036783025,0.004914542,-0.07304529,0.16392134,0.08076464,-3.6600802e-08,0.06073431,-0.07318323,0.037608027,-0.05226355,-0.05645898,0.03275728,0.0484938,0.030776162,0.031105211,-0.02527302,0.013198498,0.06386647,0.08395841,-0.027621647,0.09092646,-0.012634725,0.06109197,0.008331607,-0.04499727,-0.024182776,-0.094204955,-0.02296679,-0.02615432,-0.0865933,-0.0061411476,-0.022348676,-0.0217424,0.18936902,0.028271966,0.031458363,0.06855951,0.0007455673,0.044346243,-0.028614825,0.010161919,0.078309275,0.028362453,-0.05263397,-0.015327293,0.051657666,0.013472905,-0.034816086,-0.028465312,0.02503918,-0.0333271,-0.006402642,-0.008633269,0.017479738,-0.046289507,-0.039021406,0.027208121,-0.018590158,0.008074526,-0.01166367,-0.04811298,0.035743993,-0.05908639,0.0476887,-0.0003183365,-0.066464536,0.0099326195,-0.016643843,0.14651082,0.022676272 +2.7.2.15,"Requires Mg2+. Acetate can also act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [1]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate [1].",384,1.0,-0.089236386,-0.05705146,-0.043023795,0.034921035,0.09065967,0.02544978,-0.07593657,0.033475135,-0.07066609,0.030613188,-0.011669443,-0.05886499,-0.03715205,0.008535228,-0.017247997,0.025337452,-0.018606976,0.021272665,0.0349603,0.0041508116,0.06982183,0.002060957,-0.06256976,0.015364495,0.08474486,0.02823429,0.03693309,0.01782506,-0.017855607,-0.016716287,-0.06295552,-0.015599086,0.112764455,-0.044182744,0.061227757,0.13494202,-0.08855842,-0.03250082,0.050925728,-0.018007573,0.06299681,-0.05297666,0.023903176,-0.0771014,0.07926189,0.003366589,0.08254695,0.013397839,-0.0163682,-0.016833173,-0.05548464,0.010891329,-0.03797552,0.010829013,-0.04335818,-0.035834983,-0.0023686967,0.004019585,-0.015673086,0.03274384,0.048478,-0.014588868,-0.05884825,-0.057121094,0.00021820636,-0.0993017,0.050188497,-0.039828204,0.07812028,0.020575808,-0.022020794,-0.029792266,0.028971098,0.07038774,0.04148652,0.0021164136,0.013186217,-0.09590117,0.036889043,-0.046610333,0.044385366,-0.034861676,0.006417427,0.0071427813,0.003323411,-0.03036317,0.022694297,-0.005572783,0.010821371,0.050906397,0.060018115,0.08746013,0.037910905,-0.08034304,0.00040370997,0.012886595,-0.0006760903,0.02326114,0.022984227,-0.0043095173,-0.0008397183,0.10106523,-0.059321493,-0.024342652,-0.012916937,0.010272353,0.053799674,0.0524209,0.057183452,0.05409803,0.06920182,-0.013694111,0.04710918,0.045668557,0.009202016,0.083556876,-0.025257846,-0.11791265,-0.06513527,0.03514664,-0.042164087,-0.07405981,0.025975468,0.063925534,-0.017935054,-0.029184034,-0.0120612215,6.47714e-35,0.04818686,0.027341515,-0.022278331,-0.07385651,0.0005424095,-0.043510787,-0.08256549,-0.080590345,0.06847024,-0.12841545,0.001198592,-0.08301928,0.0024415099,0.05822621,-0.07051361,-0.036047634,-0.021361176,0.058619324,0.033820435,-0.015522414,-0.051492624,0.00480781,-0.028738858,0.007074989,0.012822155,0.029645195,0.048235606,0.026394332,-0.02148756,-0.016977934,0.029955067,-0.055138823,-0.03872993,0.03808748,0.062311284,-0.006782748,-0.0895123,-0.030855734,-0.015160963,0.066251494,-0.012697174,0.12167209,-0.01401993,0.035240483,-0.005489869,-0.07448125,-0.009460556,0.15235327,-0.009809931,0.011546076,0.077034585,-0.06588294,0.04792936,-0.07028114,-0.015466712,0.056782495,-0.006260075,-0.013570307,0.08123239,-0.01054702,0.031698935,0.03168279,-0.022943558,0.12853381,-0.02027022,0.050602537,-0.12572408,-0.02006703,0.05548478,0.044978574,-0.029315261,-0.08289206,0.08705855,0.0074133105,-0.025876563,-0.016321376,-0.09812388,0.024051331,-0.057092212,-0.024916181,0.024227984,-0.02949505,-0.036430147,0.002138908,-0.09182191,-0.009680904,0.024945654,-0.044061854,0.06722252,0.021252856,0.031061662,-0.040653598,-0.008902896,0.04712995,-6.556431e-05,-8.843254e-34,0.0709244,-0.032610357,0.07078094,-0.028508855,-0.11602906,0.066363625,-0.0123393405,-0.080344155,-0.015820242,-0.030470537,0.075851455,-0.04277032,0.05905321,-0.03290972,0.0068811015,-0.0585675,0.008988125,0.05411948,-0.04417803,-0.01569369,0.023835875,0.020603599,0.00031799678,0.030001655,0.035560615,0.0025780206,-0.09560357,0.055323947,0.046926957,0.05387617,-0.014941275,0.014993908,-0.032904502,-0.0613808,0.0065042344,0.059887376,0.026205277,-0.0077135856,-0.027575016,0.0043629333,0.05291072,0.03143947,0.020505993,0.08940598,0.016553037,-0.008337755,0.061295692,-0.023189666,-0.015777137,-0.08819347,0.053272102,-0.049781553,-0.082580246,-0.03926009,0.01617677,0.1010557,-0.03659727,0.052446686,-0.020008286,-0.07189172,-0.045849122,-0.103015415,0.06331812,-0.03739069,0.050159607,0.025025446,-0.042266317,0.12055242,0.056397222,0.024299277,0.0793374,0.080143325,0.09965766,0.03442981,-0.056738902,0.006612787,-0.06116984,-0.030989911,-0.036463458,-0.053527743,-0.020862134,0.019794857,-0.089022204,-0.037822384,-0.07983901,-0.02959839,0.013777842,0.06213947,-0.04780215,0.012048367,-0.049414158,-0.08590068,-0.04528981,0.06706837,-0.011967174,-3.4478397e-08,0.017859953,-0.032069504,0.106496,0.03967157,-0.0040252917,0.018216094,0.0314828,0.003206283,0.07993989,-0.034768235,-0.047222648,0.04095683,0.028237319,-0.061934926,0.032471936,-0.0024767476,-0.020591171,0.038858972,-0.062198494,-0.021024311,-0.04178802,-0.11203451,-0.09199427,0.04730578,0.03604114,-0.047230847,0.022715671,0.0942198,-0.043519087,-0.032327216,0.03667495,-0.0049238233,0.010481858,-0.052055687,-0.013435094,0.011204912,-0.006384786,-0.051777784,-0.01777304,-0.019624107,-0.031952877,0.063920096,-0.08751024,0.052276295,0.002825309,-0.0052927067,0.03899664,0.021400224,-0.08105628,-0.052045394,0.0331865,-0.07381051,0.0023304138,-0.026702434,0.017105505,0.0361698,0.028361777,0.028445624,0.017378489,0.0027374357,0.06906163,0.044906206,0.13949446,-0.06089185 +2.7.3.2,N-Ethylglycocyamine can also act as acceptor.,384,1.0,-0.032122042,-0.06501743,-0.062120467,-0.013666424,0.009802399,-0.027959576,0.097640656,0.024790522,0.035215817,0.026377011,0.03305082,0.056900706,-0.024560435,0.10149067,-0.016691336,0.055111576,0.0047628386,-0.053070866,0.016302435,0.0647369,-0.0030838267,0.084329724,0.042911798,-0.06571277,-0.056178644,-0.0024981252,0.01754361,0.018693592,0.065576226,-0.08139615,0.012317504,0.050967094,0.015099888,0.036219068,-0.019424621,-0.0059658084,-0.06929768,0.007763573,0.013566291,0.012217195,0.017897617,-0.0042717755,0.024251081,-0.011483193,-0.046246033,-0.027745504,-0.016627625,0.017292192,0.019694312,-0.032044847,0.09439335,-0.015860613,0.050867327,0.12116718,0.012181818,0.037404075,-0.15870416,-0.03387173,-0.07623874,0.035951898,-0.0074808183,0.029194914,-0.025055202,-0.013328448,0.0790185,0.0043117087,0.017526032,-0.06264451,-0.0173926,0.014812194,0.010399312,-0.023706697,0.04030896,-0.030685633,0.033728257,-0.033790685,-0.016216207,0.024232883,0.015567201,0.033119775,-0.104551904,0.06544773,0.009043119,0.010871112,0.046648387,0.011308539,-0.050177425,0.09151796,-0.028676149,0.034214467,-0.045268912,-0.048960738,0.046931308,-0.06685913,0.0021679443,-0.0965067,0.035449233,0.017148605,-0.031070359,0.016061906,-0.0011892939,0.08719622,-0.06419065,-0.056682996,-0.06479928,-0.005209476,0.08401311,-0.04541941,-0.00479757,-0.0028986698,-0.072865024,-0.051401574,0.052484177,0.09743647,-0.076875746,0.052516665,-0.025509173,-0.07776639,0.024253411,-0.107350074,-0.038139243,-0.022636713,-0.044265047,0.014102306,-0.015201935,0.051895697,-0.014954244,-7.267094e-34,-0.023897897,0.005303765,-0.00020982663,-0.06279135,0.043775603,0.074816085,-0.017431965,-0.0021465658,0.06820917,-0.08591043,-0.057492983,-0.00078099483,0.06175845,0.09042055,-0.05374781,-0.0014077566,-0.015253684,0.092971995,0.07148919,-0.062184542,0.026594391,0.04723078,-0.071393795,-0.0059262775,-0.15607537,0.0122340545,-0.012052454,0.04957598,0.101515144,-0.03773595,0.056016214,0.015373173,0.0020930711,0.040490527,-0.0031557656,0.06119376,0.022516133,0.05053316,-0.002232799,-0.03976879,-0.015285659,0.06994939,-0.070762254,0.052683447,-0.0042457515,-0.036503635,-0.0808115,-0.07203563,-0.08174727,0.06012047,0.019797247,-0.040471327,0.014051129,-0.0866589,-0.040383488,0.0111862235,-0.0011328615,-0.010664919,-0.041044142,0.0072732843,-0.024066273,-0.019598298,-0.05877792,-0.023067113,-0.058107022,0.018999908,-0.012370034,-0.11114667,-0.011919132,-0.0067800027,-0.05256862,-0.0033587883,0.016222423,0.072488174,0.048138436,-0.035544217,-0.06822203,0.024716536,0.0461357,-0.007385414,-0.054751296,-0.048417695,-0.041239925,0.043800008,-0.07107721,-0.040550854,0.051848922,-0.08950178,0.04780212,0.0013030889,0.02141643,-0.103880726,-0.076904446,0.012096413,0.077589825,-2.0934581e-33,0.065405905,-0.0704172,0.018679185,0.030954808,0.060208097,0.06827943,0.061144035,-0.05837765,0.08471295,-0.042414356,0.09860541,0.0019573478,0.023134781,0.041974183,0.056401644,-0.032866336,-0.026171366,0.1241262,-0.034423534,0.034341916,-0.04475453,-0.00067030644,-0.02675474,0.04526243,0.022447918,0.08815391,-0.023984434,0.0020143455,-0.022280235,0.019062772,-0.079182334,0.00024886668,-0.048370697,-0.050167464,0.03436014,0.05518059,-0.021993842,-0.003995383,-0.13023812,-0.059954688,0.029951256,0.03997812,-0.008544841,0.11570234,0.00582584,-0.033028405,-0.048992522,-0.010260905,-0.043298766,0.011628312,0.008572391,0.06448905,0.048123583,-0.027218126,0.08901128,0.10343487,0.050956003,-0.054078802,0.0019150425,-0.02854005,-0.031110363,0.016504629,-0.049955577,0.028918333,0.018453982,-0.097474635,-0.032837667,0.06254019,0.09881707,-0.030366393,0.045659646,-0.023254491,0.06667152,0.043211006,-0.02815711,-0.10141428,-0.023215687,-0.12419896,-0.01154638,-0.06574705,-0.09540796,-0.020726614,0.026953598,-0.011795568,-0.025195738,-0.0019767527,0.07628415,-0.050948706,-0.02989689,0.030632637,0.06912587,-0.009942093,-0.072250195,0.044786975,0.034323312,-2.483716e-08,0.02790257,-0.08684471,0.01342826,-0.028539557,-0.038164526,0.0016288458,0.033214655,-0.035387892,-0.0105225425,-0.036244377,0.08395253,0.09174675,0.044420507,-0.0029416003,0.034430202,0.009445348,0.013329495,-0.0066616233,-0.054085936,0.008059575,-0.15928395,-0.020687502,0.011626041,-0.030521857,-0.0025980351,0.018629093,-0.019643804,0.06565303,-0.018080095,-0.011255003,0.0369247,0.047671396,0.006334874,-0.0609481,0.009602323,0.04515936,0.114581555,-0.04263649,-0.010364239,0.015166569,0.010255223,-0.011803805,-0.06784969,0.023274364,0.05895096,-0.030181872,0.002333679,-0.032646567,-0.050563395,-0.023879115,0.022322357,-0.019450642,0.03347432,-0.07141863,-0.04424491,-0.002427447,-0.08734457,-0.015343221,0.0020288506,0.008350728,0.024622958,0.042449452,0.13730997,0.024044229 +2.7.3.5,Also acts on methylated lombricines such as thalassemine; the specificity varies with the source species.,384,0.99999994,-0.006784571,-0.05500327,-0.062933534,-0.0253888,0.06130995,0.038155075,0.004300788,0.026605496,0.072531536,-0.03027966,0.0057615503,-0.053936556,-0.07295115,-0.025349643,0.049929235,0.10562559,-0.04508458,0.025161084,-0.052840397,0.030854091,0.16593125,0.03550474,-0.017591486,-0.03137304,-0.07179076,0.0037070268,0.011815607,0.036821052,0.032063987,-0.050881945,0.0010992391,0.13527873,0.04010419,-0.021621311,-0.0013367604,0.05292512,-0.057912618,-0.039238602,0.03312332,0.077599265,0.09267036,-0.035742804,-0.020312821,-0.02240405,-0.088561095,-0.04065189,0.03472083,0.025655027,-0.111512095,0.0058997017,-0.06865633,-0.061049063,-0.053851593,0.06214142,-0.03782552,-0.01652741,-0.05960098,-0.0016102917,0.019891245,-0.0011763156,-0.011569375,0.047240797,-0.00017163895,-0.007711746,0.030136822,0.008601072,0.03207921,-0.022540892,0.040816475,-0.11438186,0.0069496077,-0.054026663,-0.060458202,0.050152835,-0.006825048,-0.018100632,0.08966476,0.0075378045,0.042087466,-0.06530438,-0.06134756,0.06308373,0.11408468,-0.02340973,0.06834031,-0.027057124,-0.059238523,0.065713644,0.014633196,0.070911475,0.06713423,0.028418744,-0.010106249,-0.03719494,-0.036590677,0.046728227,0.07159483,-0.018944677,0.029640388,-0.036071666,-0.0013786015,-0.03134684,-0.13393773,-0.016009038,-0.02404953,0.005996167,0.016854635,-0.0140922675,-0.03567309,-0.036121346,-0.03243018,-0.0016459175,0.052620873,0.016243722,-0.05051159,0.008681202,0.03811841,0.026081717,-0.056711394,-0.051154938,-0.059828445,-0.024629695,0.06054684,0.0104380585,-0.043207902,-0.0061811525,-0.13420807,1.0089588e-33,0.09753966,-0.032384243,-0.024782756,-0.04755792,0.023357704,-0.03999337,-0.022745632,0.025188176,0.00518559,-0.0070016864,-0.02520389,-0.08126623,-0.015096014,0.061014418,-0.040116087,0.033014692,-0.059233595,-0.026599636,0.0037338943,-0.06677513,-0.02567685,0.06678207,-0.061049365,-0.0039047461,-0.061654426,0.037660543,0.008787436,0.039218724,0.014979878,-0.021087848,0.07574422,-0.13704018,0.0035107145,-0.010062664,0.05766041,0.13418677,-0.08574015,0.06885722,-0.051331073,0.07592821,0.01348791,0.0037815773,-0.037357446,-0.037287485,0.03129542,0.01934704,-0.08579441,-0.0040850295,0.0453612,-0.0061698793,0.011352023,-0.034617286,0.051330987,-0.0049785012,-0.045502808,0.044143766,-0.028144164,-0.013402704,-0.010456212,0.030327715,-0.0028343287,-0.020041384,0.030955156,0.013101299,0.072525255,0.033195212,-0.07747004,-0.060799554,-0.06550791,0.017956166,-0.0140634095,-0.02862013,0.09939668,-0.031703055,0.028807271,-0.022106186,-0.12894638,-0.0123098465,0.04973239,0.06797248,0.020807512,-0.026584871,0.043326844,-0.044235073,-0.15910287,-0.021205852,0.02277471,-0.054993246,0.00077393465,0.031121863,0.06591597,-0.12511507,-0.058723506,-0.070158735,0.08527901,-2.0977782e-33,0.021847434,-0.06718754,0.021280177,0.0026212805,0.026986845,0.08263468,0.00064063066,0.0016001364,-0.008721262,0.008886687,0.085307375,0.024730565,-0.07404736,-0.03519746,-0.013768372,0.0040766597,0.03218714,0.07891921,-0.026291706,0.014850921,-0.065845676,-0.0067302687,0.0039047697,0.030616922,0.019176563,0.018000089,-0.012650719,0.0164616,0.079334915,0.0030595958,-0.03360557,0.018273905,-0.092769586,-0.110128924,-0.017404005,0.021119662,-0.043058526,-0.011748627,-0.07828823,0.006998449,0.024731474,-0.05894755,0.05253703,0.11546174,0.06392002,0.08555868,-0.042513847,-0.07793931,0.007423031,-0.020177308,0.06297616,0.030214837,0.011070874,0.06448645,0.065758795,-1.0923033e-06,-0.011747204,-0.02253057,-0.017736591,-0.048542492,-0.05080489,-0.03160652,-0.044795714,-0.07558912,0.049701393,0.0646516,-0.011766799,0.0430328,0.1024257,-0.009819596,0.13219047,0.027283723,0.0039113103,-0.04092945,-0.100292265,-0.09028392,-0.031000322,-0.07992058,-0.039150137,-0.0008908304,0.01836794,-0.022835152,-0.024537122,-0.010883477,-0.024839157,-0.03834336,0.04991502,0.07485969,0.015797041,0.029497337,-0.05032609,-0.026493076,-0.052462075,0.080372386,0.008780176,-2.763836e-08,-0.009347493,-0.09773149,-0.010408431,0.014256434,-0.0379796,0.08458858,0.037099242,0.022703916,0.005530207,0.0090140095,-0.022196723,0.079650946,0.08972118,0.018439535,0.11858974,-0.04275906,0.016428772,-0.0029456909,0.006728409,-0.070707224,-0.024839148,0.01180109,-0.031765338,0.061095685,0.04288426,-0.03188542,0.028476823,0.032635763,0.092835546,-0.029758437,0.028076291,0.047891684,0.06521927,0.0084634265,0.00935514,0.043767363,-0.029230207,-0.04821688,0.016402433,-0.0018788384,-0.032602403,0.015626095,-0.09765226,0.04425486,0.016349494,0.0013129333,-0.017180124,0.057905443,0.021878297,-0.0149015235,-0.00030297524,0.008869889,-0.01767102,-0.0019459327,-0.100957006,0.020110305,0.019250227,-0.042993225,0.057721063,-0.03532178,0.04606901,-0.028408831,0.100004904,-0.0066014254 +2.7.3.6,"Also acts, more slowly, on taurocyamine.",384,0.99999994,0.079242975,-0.14835815,-0.010364524,0.03609046,0.04026119,-0.038475625,0.021434609,0.07524125,0.0695287,0.013743231,-0.025042936,0.10767158,0.030846516,0.1416184,0.005738893,0.069665514,0.019109447,-0.04447886,0.023628732,0.04806566,0.009597208,0.002354939,0.040948916,-0.0024912066,-0.041719075,0.054784983,0.008642203,-0.0070486963,0.015807107,-0.034514617,-0.016037002,0.0590688,-0.0004981931,-0.03585042,-0.04519795,0.062068,-0.07048307,0.081517324,0.0036350924,-0.030085204,0.07987228,0.0064925607,0.022559226,-0.055837683,-0.013371193,0.012159093,0.022546176,-0.04518958,0.074780464,0.05731708,-0.015968606,-0.04483228,0.006835467,0.052111976,0.0030312422,0.07118742,-0.124817386,-0.03197198,-0.01707012,-0.002634034,-0.10739295,0.019762278,-0.04877391,0.021149717,0.07552937,0.039318964,0.05821437,-0.030282589,0.026022103,0.044451635,0.036889885,0.014545657,0.053886525,-0.004347331,-0.005274356,-0.05359704,-0.023739114,-0.01813785,-0.0053018476,-0.06293707,-0.07886904,-0.022660663,-0.031663705,0.027313894,0.06957158,0.011153391,0.03993354,-0.102127045,-0.059974607,-0.0047167833,0.0052996036,0.04521663,-0.08720578,-0.05034357,0.0047731213,-0.046762057,0.0018192257,0.01888367,-0.083945274,-0.0030426986,-0.02236604,0.016871702,-0.0072462903,-0.03564101,-0.006045721,-0.029593103,0.06141811,-0.021484008,-0.036935277,0.06302705,-0.03473619,0.011680137,-0.03258264,0.08950691,0.036418933,0.088497534,0.004752918,4.6364737e-05,-0.07955925,0.0021991783,0.017869705,-0.026154842,0.004209308,-0.049179245,-0.043550506,0.05899743,-0.0015168673,-1.8782378e-33,0.0129341055,0.027653687,-0.0044673802,-0.033673737,0.023525514,0.027598882,-0.061977495,0.0112442775,0.08339013,-0.009086603,0.004102072,-0.058731567,0.049647637,0.028572993,0.020102514,-0.075703375,-0.0071360627,0.023335448,0.04668515,-0.035386615,0.004822115,0.081339136,-0.07425171,0.048623107,-0.07537578,-0.032254137,-0.031076051,-0.0026081195,-0.06772174,0.004266579,0.022657214,0.057875685,-0.07847038,-0.006039653,0.0059633227,0.10687188,-0.035798315,-0.011353278,0.024205111,0.020267785,0.024813306,-0.009928985,-0.06329705,0.03255651,-0.032509178,-0.0396,-0.035811484,-0.009044608,-0.033065867,0.057064295,0.066907,-0.04423998,0.08254954,-0.09401125,-0.07642224,0.020486245,0.050389845,-0.11462012,-0.0048729233,0.07662009,-0.0032801002,-0.012539523,-0.03115139,0.037697196,-0.034994546,-0.051843945,-0.05101841,-0.099684864,-0.022750013,0.020380922,-0.023031551,-0.009602397,0.07134618,0.03122729,0.007529142,-0.010330971,-0.047973663,0.002452089,0.009960572,-0.056589305,-0.025350614,-0.10101299,-0.007804994,0.044444222,0.0019493004,0.0036683318,0.045042604,-0.093710534,0.016083634,0.008537376,0.019044206,-0.08278845,-0.06947078,-0.012846635,-0.027678536,5.914805e-34,0.011492251,-0.06045416,0.021394776,0.064963944,0.030253274,0.087221436,0.019351,0.03934345,0.024818536,-0.06765227,0.12750824,-0.046570193,-0.089877285,0.037792064,0.018663136,0.05526622,0.08640917,0.076274276,0.042024422,-0.003900357,0.016850969,0.04902423,0.009266413,0.093239985,0.04897288,0.05564819,0.020146893,-0.0497479,0.018845895,0.02253239,-0.034845866,0.029582037,-0.057074454,-0.10532493,-0.03736527,0.067081995,0.012782719,-0.046323936,-0.06612762,-0.075205855,0.054217003,0.02715122,0.09334281,0.05224968,0.014961008,-0.00648984,0.018566051,-0.027077766,-0.12325555,0.064913996,0.05491999,-0.016030395,-0.004198894,-0.003558708,0.04170128,-0.00431268,-0.0009666851,-0.13816209,-0.013314889,-0.020971019,-0.04138855,0.116160706,-0.087195344,-0.019804647,0.08008231,-0.052228298,-0.026752986,-0.0038331358,0.08258622,0.0019265015,0.04453946,-0.031839687,0.03196784,0.09755048,-0.077707395,-0.025401685,0.011972878,-0.060403578,0.015886601,-0.10775315,-0.05188025,-0.02092387,0.03733085,-0.053127997,-0.14185312,0.016254274,-0.010510221,0.023132872,-0.0047831386,0.031397488,0.014110175,-0.01738386,-0.011206087,0.050029155,0.044931047,-1.729931e-08,0.0040779975,-0.04374104,0.015034942,0.013306996,-0.009773524,0.07172095,0.081217825,0.03646341,0.014043587,-0.09201791,0.0049086623,0.08340226,0.11490273,-0.008810133,-0.019015536,0.05542346,-0.00999351,0.013586536,-0.052586537,-0.009147134,-0.09824178,-0.03137958,0.023580607,-0.0125694405,0.00043914243,-0.01799147,-0.021422973,0.10927865,-0.03876983,-0.06958465,0.05000961,-0.01845368,-0.07556171,-0.036490325,-0.035940636,0.019294027,0.11964068,-0.0537142,0.05267666,0.050066713,-0.074626006,0.024993675,-0.041702956,0.040698584,0.030330792,-0.07460163,0.0005061265,-0.08928641,0.067162864,-0.059920613,0.036940884,0.035540026,0.01985936,-0.07381582,-0.049117323,0.032648105,-0.037433956,-0.07655663,0.017851828,-0.041067723,0.02530823,0.010822545,0.10027791,0.030264638 +2.7.3.7,"Has a little activity on taurocyamine, lombricine and phosphotaurocyamine.",384,1.0,0.07354089,-0.077216424,-0.010671871,-0.019029474,0.058735367,-0.001115846,0.06129557,0.07510693,0.043178998,0.013624285,-0.056979436,0.06300647,0.012629319,0.11414231,0.022897152,0.100357875,0.032067165,-0.0791375,0.035520215,0.052151054,-0.0039046057,0.04512197,0.07650945,0.044893235,-0.04056301,0.05384867,0.04249225,0.0003861441,-0.016357657,-0.003807902,0.0220454,0.083867,0.036440432,-0.045634,0.018903377,0.025508769,-0.07451633,0.06365758,0.021646759,0.022391468,0.08006136,0.011016298,0.046735194,-0.029071804,-0.05074026,0.010365739,0.008092041,-0.05572763,0.03548227,0.028834896,0.032276135,-0.065662265,0.04787663,0.069208376,-0.016545733,0.067390315,-0.15744829,-0.019444317,-0.034046374,0.046116114,-0.058106046,0.057926472,0.004786558,0.037419442,0.040090133,0.025682738,0.015027582,0.013386248,0.05607234,-0.0091753,0.026837813,-0.028465902,0.030843321,0.0651702,-0.0041660774,-0.0040064575,0.02042385,-0.0041467054,0.05607096,-0.10834001,-0.081466295,-0.045650642,-0.01825135,0.0664547,0.055822086,-0.0013148078,0.007625517,-0.047773425,-0.01454098,-0.070734374,0.050110098,0.03070107,-0.03407653,-0.08136297,-0.023222608,-0.03692347,0.0061520417,0.009798474,-0.119038165,0.038125,-0.01121696,0.02549027,0.016374014,-0.05465916,-0.040252704,-0.030388884,0.07435527,-0.06968503,-0.043075386,-0.034409534,-0.031420067,-0.0077470145,0.008558715,0.074323535,0.009676612,0.057188105,0.07973594,-0.022639545,-0.07125128,0.047619324,-0.016472252,-0.051056333,0.05784574,-0.0445109,-0.07939893,0.06912116,-0.058515426,3.777194e-33,0.049745273,0.047961548,-0.011322729,-0.039266087,0.02825208,0.04466126,-0.005549716,-0.012708197,0.05600056,-0.009109292,-0.037575714,0.014074834,0.059160788,0.04304225,0.076025784,-0.037402917,0.008834326,0.0012841253,0.11762814,-0.03041457,-0.0104856845,0.06170692,-0.034467872,0.06925155,-0.03537914,0.020967433,-0.007843081,-0.033364013,-0.03127396,0.015989982,0.0103938,0.03434171,-0.03234643,-0.056907967,-0.06576134,0.09492491,-0.0956189,-0.028442003,-0.020911133,-0.01378011,-0.007895681,-0.028317364,-0.06311207,0.032383405,-0.06467483,-0.04635216,-0.023485048,-0.028285373,-0.060281307,0.046328787,0.0002806474,-0.030964907,0.042655572,-0.13121192,-0.091465026,0.002690541,0.013797642,-0.13787413,-0.0009501628,0.023482854,0.050129656,0.039986856,-0.019500561,-0.020399077,0.0145761855,-0.060235817,-0.013123367,-0.120683245,-0.04645733,0.005924121,-0.02232309,-0.042147573,0.03606001,0.016477505,0.027344411,-0.01868685,-0.05832553,-0.026253864,-0.008295154,-0.03234007,0.016985457,-0.11546309,0.07740468,0.0690139,-0.022501115,-0.024098007,0.025538659,-0.037398815,-0.011022467,0.036718294,0.008682661,-0.0971063,-0.052033488,-0.041833125,-0.02728153,-3.769252e-33,-0.038836557,-0.055235572,0.012319983,0.028311906,0.019811278,0.06894983,0.052776046,0.03401851,0.032769322,-0.007994614,0.13648613,-0.06244618,-0.086956285,-0.008326684,0.030592725,0.04094931,0.017480075,0.062845655,0.055881504,0.012757999,0.010633299,0.02220151,-0.015658954,0.06612835,0.056555122,0.072787665,0.044848356,-0.07750829,-0.010168081,0.038204234,-0.031565085,0.04924607,-0.0155198295,-0.10961697,-0.020387795,0.03769144,0.01415816,-0.075341046,-0.09358694,-0.10061688,0.028488286,0.030184396,0.056834783,0.06683777,-0.022634858,-0.00027753375,-0.052204717,-0.0059411637,-0.07487567,0.064256124,0.04313332,-0.027474262,0.033435408,-0.020704435,0.012825389,-0.0017777815,-0.025345443,-0.057341017,-0.05053068,-0.03440275,-0.051798765,0.09235358,-0.13441832,0.008562314,0.09868594,0.0013484869,-0.03921177,0.023001863,0.037140906,-0.01050176,0.088170655,-0.0137433475,0.10086153,0.02687606,-0.07357992,0.039005768,-0.026918203,-0.074127495,0.044023156,-0.06314919,0.034241416,-0.06429827,0.007102991,-0.014069076,-0.041335203,0.010733843,-0.024671772,0.06417402,-0.004214542,0.045852672,0.008813289,-0.0019705542,-0.09657503,0.031318016,0.040074024,-2.6178109e-08,0.059389517,-0.11802051,-0.016057476,-0.0006890904,-0.028644975,0.0070980648,0.0745948,0.017850343,-0.00019863367,-0.037728693,0.0029542234,0.10310297,0.007898162,-0.021876317,0.01534783,0.051373623,-0.0027599083,0.023115326,-0.04634189,-0.0074559804,-0.04981485,-0.011134739,0.009883062,0.024327934,0.042096823,-0.026698984,-0.0060683847,0.064437434,0.013202567,-0.07573821,0.10092455,-0.0046519474,-0.03871028,-0.010239605,0.0020402262,0.04224069,0.06661429,-0.07528621,0.0069134776,0.030324746,-0.09705944,-0.004220603,-0.036644742,0.040292233,0.023115968,-0.09057095,-0.012556605,-0.04459155,0.054303173,-0.13194178,-0.03329778,0.022948476,0.027824273,-0.078567676,-0.09724168,-0.001347701,0.014584785,-0.118937835,-0.0044271806,-0.07494616,0.018238546,0.021341491,0.10249063,0.037464883 +2.7.3.8,"Has a wide specificity. In the reverse direction, N-phosphoglycine and N-phosphohistidine can also act as phosphate donors, and ADP, dADP, GDP, CDP, dTDP, dCDP, IDP and UDP can act as phosphate acceptors (in decreasing order of activity).",384,1.0,-0.08421451,-0.07045297,-0.003494212,-0.087101325,-0.015770428,-0.013151361,0.047718216,0.0027173753,0.028292868,0.050732266,0.049842287,0.098508336,-0.052245814,0.07592226,-0.06650114,-0.014225409,0.023592025,0.031985175,0.03158797,0.06982012,0.07529139,0.030719088,-0.048710715,-0.050740413,0.028861588,0.023712726,0.049067397,-0.029604264,-0.004633324,-0.066880636,-0.07689555,-0.02183237,0.011975072,-0.05095411,0.012921233,0.083257295,-0.04164265,0.058656614,0.002207276,0.0609973,0.060193345,-0.09547706,0.020708509,-0.0051187146,-0.055711556,-0.03036854,-0.039429076,0.015613153,-0.028884886,-0.011180295,-0.0068572336,0.027273497,-0.020362275,0.082632825,-0.04132438,0.021595491,-0.059015863,0.05662513,-0.054467876,0.0018665857,-0.01785432,0.011697326,0.007434236,0.0012100852,0.18445466,0.028799271,0.039567985,-0.024889702,-0.03520292,-0.022438776,0.032805454,-0.03115928,0.073356725,-0.0547408,0.020596558,0.08327344,-0.069865026,0.053064752,0.053100802,-0.07490483,0.07056281,0.0741137,-0.02831634,0.018178463,0.033827327,0.036775608,-0.10962564,0.047470238,0.009053461,0.002691489,-0.056643307,-0.031929407,0.0877553,-0.011219609,-0.038060594,0.0013390857,-0.03691396,0.025564162,-0.0013076046,-0.027860943,-0.043606065,0.13817321,-0.06017378,-0.06653355,-0.031268653,-0.0075362334,-0.06433861,-0.05496226,0.062275812,0.07188565,-0.07769675,0.05752329,0.045400172,-0.008867885,-0.00477586,-0.02619372,-0.067824185,-0.052071553,-0.035923827,-0.09537631,-0.05623457,-0.0891364,-0.036917925,0.00800457,0.02979157,0.09797233,-0.063002594,6.9684063e-34,0.054245964,0.017587595,0.07249744,-0.03414849,-0.009375719,0.009853306,-0.041052252,-0.067409135,-0.03129898,-0.053629372,-0.03861827,0.0063155866,0.033788405,0.04054463,-0.057995547,-0.011317884,-0.010873029,0.09751795,0.09736289,-0.0013964579,0.055686124,0.094952315,-0.0650387,0.026152851,0.057447143,0.010725159,-0.08863648,0.006205176,0.018688992,-0.0070389383,0.076648995,-0.05487655,-0.070337914,-0.012946671,-0.027814077,-0.07462111,-0.07001887,-0.070775196,0.0108082965,-0.068330556,-0.06734226,-0.016846446,-0.020597644,0.08311479,0.03258607,-0.009400233,-0.034260754,-0.033033583,-0.06560062,0.035159107,0.004202055,-0.07038379,-0.014857029,-0.043660033,-0.014011169,-0.07970343,-0.04123218,-0.047964115,-0.005436719,0.075959384,0.026582707,0.027417766,-0.04558442,-0.04901823,-0.062823065,-0.0060113613,-0.017208865,-0.06005134,0.055203076,0.061250556,0.019038878,-0.019355463,-0.0012928972,0.06841072,0.0038471902,-0.052432843,0.061438885,0.009853028,-0.00042399243,0.042228486,-0.025893772,-0.051686577,-0.017467156,-0.009325379,-0.03485564,-0.001510454,-0.0019198682,-0.124009036,0.03399768,-0.036701173,0.03875658,-0.053847115,-0.090928115,-0.015615851,0.016717479,-2.145861e-33,0.072728105,-0.033049025,0.008809534,-0.020014679,-0.030549701,-0.03906795,0.04519681,-0.028696733,0.11366808,-0.06984994,0.025032094,-0.034973793,0.057808675,-0.0032490613,0.03985278,0.03671332,0.00040395765,0.039244387,0.0548641,-0.0043900623,-0.03515147,0.092343956,0.0003122032,0.10192188,0.061556514,0.02002502,-0.08068665,0.05994487,0.044139273,0.030263001,0.023896204,0.070479244,-0.087703444,-0.033193853,-0.03991533,0.028946934,-0.08256265,0.0029277394,-0.018954033,-0.034900334,0.04511626,0.012230413,0.06268227,0.044243008,-0.03266789,0.0042988462,0.009331899,0.013322292,0.00078395434,-0.050663967,0.04577592,0.07638365,-0.0049218186,0.049849123,0.049694277,0.13372545,0.06254289,0.036802772,-0.015371307,-0.03588857,0.038248755,-0.044720467,-0.00061678316,0.023610504,-0.07004898,0.0516122,0.06433113,-0.026436733,0.036466353,-0.039792333,0.018812433,-0.01874695,0.069981866,0.023331674,0.029615715,-0.037986144,-0.12252029,0.040861987,-0.009426612,0.0060846745,-0.07657926,0.04734711,-0.0155987535,-0.011584282,0.013575915,-0.0070763608,0.04551824,-0.035349827,-0.02601509,0.050378345,-0.05981264,-0.025057342,-0.020491274,0.07937319,0.04985622,-3.8257152e-08,0.09350144,-0.013601667,0.083918005,-0.06072194,0.01615003,-0.07181824,0.0033755067,0.054816958,-0.0003908445,0.007527819,0.019604284,0.098161824,-0.032476008,-0.02554018,0.10849813,0.02484942,-0.009076522,-0.012971418,-0.08367612,-0.04023888,-0.042358026,0.012601604,-0.06692775,0.04686806,-0.0041091684,0.093862206,0.092939235,-0.043071292,0.018069144,0.006976264,0.07058899,-0.024643876,-0.013749768,-0.05094311,0.01957035,0.02817584,0.0313543,-0.057128757,-0.027263297,0.00309462,-0.06644665,-0.08174122,-0.037739728,0.060038842,-0.009290152,0.055379737,-0.02214565,0.02053492,-0.03842115,-0.03552919,-0.024280641,-0.05874069,-0.053611897,-0.1112883,-0.042215206,0.002132612,-0.023436204,-0.0042663203,0.023870971,0.005231771,0.006551954,0.042272322,0.16687445,-0.045765694 +2.7.3.9,"Enzyme I of the phosphotransferase system (cf. EC 2.7.1.191, EC 2.7.1.192, EC 2.7.1.193, EC 2.7.1.194, EC 2.7.1.195, EC 2.7.1.196, EC 2.7.1.197, EC 2.7.1.198, EC 2.7.1.199, EC 2.7.1.200, EC 2.7.1.201, EC 2.7.1.202, EC 2.7.1.203, EC 2.7.1.204, EC 2.7.1.205, EC 2.7.1.206, EC 2.7.1.207 and EC 2.7.1.208). Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. A similar reaction, where the protein is the enzyme EC 2.7.9.2 pyruvate, water dikinase, is part of the mechanism of that enzyme.",384,1.0,-0.035423778,-0.031146118,-0.12743497,-0.051186576,0.093922794,0.08627982,0.020927567,0.095771976,0.03951229,0.056830008,0.032614697,-0.032034405,-0.051291913,0.11888391,-0.022845808,-0.013076316,-0.099325076,-0.014657782,-0.010162149,-0.04686615,0.10687229,0.040344972,-0.02624936,-0.010831839,-0.022040602,0.0050117327,0.07208572,0.007776275,-0.03515086,-0.0243174,-0.0030749207,-0.12620218,0.024482742,-0.061855655,0.09363053,0.15643193,-0.05024182,-0.10989143,0.051431168,0.030793048,0.08445256,0.09712674,-0.016553149,0.028387927,-0.017396117,0.039534274,0.00022853204,0.05991488,0.0019831294,-0.030060591,-0.026941722,0.02159654,-0.022577235,0.026051242,-0.01939522,-0.021707399,-0.046145972,-0.012121919,-0.002517882,-0.04546097,-0.017403131,0.009706813,0.047078416,-0.021386147,0.022190234,-0.058682945,0.04078611,-0.08517439,0.04358361,-0.029804429,-0.07841424,-0.019955449,0.03421256,0.07149028,0.046957724,-0.028631797,-0.07800034,0.031607125,-0.02701693,-0.012339428,-0.0016124672,-0.054622315,0.0301212,0.0100251995,-0.011568929,-0.02746892,-0.015657775,-0.0068921843,0.06761376,0.027110612,0.027935361,-0.048012394,-0.0076458463,-0.020526418,-0.022377785,0.009499534,0.044233743,0.019833675,0.058359843,-0.054403033,0.03083084,0.0677439,-0.07185086,-0.03701159,-0.004365778,0.043852217,0.034622885,0.05824581,-0.007857174,0.0070716413,0.006025084,0.020841774,0.08173758,-0.0016501838,0.03613092,0.08878973,-0.0005976836,-0.056759614,-0.068407305,0.033587698,0.010739089,-0.032253604,0.077150375,0.12014421,-0.052262776,0.08665262,-0.1747126,-2.8608305e-33,0.03587904,0.015433772,0.055664226,-0.05757254,-0.005675246,-0.009276141,-0.11552387,0.022271961,-0.030565966,-0.05452065,-0.099414155,-0.009341368,0.055593543,-0.051923156,-0.07577778,-0.03227978,0.020545322,0.035578117,0.01986772,-0.027414508,-0.007184458,0.02196656,0.030200206,0.015882341,0.07404159,0.05264431,-0.060647875,0.009483055,0.06155956,-0.024850024,-0.00653361,-0.08347983,-0.06549755,0.018988825,0.060031645,-0.059885673,-0.042697422,-0.051428434,0.010702456,-0.02718188,-0.027604716,-0.006140516,-0.022829905,-0.030763868,0.043581963,-0.050242893,-0.0079750065,0.074242555,0.030507524,-0.020997625,0.04085801,-0.053270083,0.11781669,-0.037287056,-0.09843274,-0.020870758,0.046140578,-0.05566185,0.05248637,0.08514578,-0.002798461,0.06471015,-0.038230337,-0.0148883695,0.040703412,0.026637794,-0.059053753,-0.018215932,-0.002754037,0.050129674,-0.119509235,-0.0042659338,0.065013774,-0.024457643,0.07948121,-0.037630208,-0.06904831,0.01801068,-0.075886115,0.006808939,0.016463665,0.013781804,0.017429043,-0.037314948,-0.08616833,-0.02565165,0.002315282,-0.09532887,-0.0033819177,0.07020995,0.053310774,-0.0606008,-0.011879987,-0.008604919,0.015955022,1.7171705e-34,0.047748145,-0.094531894,0.011103428,-0.032188762,0.010757914,0.07468462,0.088201515,0.010922806,0.05601312,-0.102214165,0.061591975,-0.029994447,0.012161412,-0.023328213,0.008994781,0.06767945,-0.00015996932,0.16197175,0.019904127,-0.021877173,0.008703706,0.0859878,0.0314717,0.017777838,-0.0022520097,0.015281232,-0.023419503,0.07521215,0.016708046,0.060979385,-0.028921623,0.034317084,-0.07084684,-0.054997094,-0.022462843,-0.0071744183,-0.11289573,-0.029632252,0.015774095,0.061134264,0.0647011,0.0017452285,0.050762326,0.005706821,0.0046602623,0.1257375,-0.027281038,0.056088086,-0.03147877,-0.017965294,-0.039063137,0.026924498,-0.02544938,0.06132683,0.053188246,0.07222618,0.010916478,0.068115994,-0.030361732,-0.007676054,-0.020626338,-0.099360004,0.0030847995,-0.01340473,0.04017118,0.0031662777,-0.03542081,0.028883405,0.06324867,-0.01564149,0.03376375,-0.04985103,0.083003506,0.027265854,-0.03466988,0.0062243626,-0.07663379,-0.025894947,0.02137397,-0.019662756,-0.024027767,0.07386173,-0.007677557,-0.06100442,0.034895226,-0.011309496,0.0151180895,0.06249523,-0.030425306,-0.008612251,0.0047619417,-0.043313418,-0.01575907,0.02875466,0.0976153,-5.8894898e-08,0.036686115,-0.036490835,0.034827247,-0.014165209,0.008994229,0.015765289,0.012680176,0.022355163,0.03880566,-0.004939222,0.059536323,0.038845893,-0.009135013,-0.08037513,0.0001900125,0.033430405,-0.078394935,-0.016472202,-0.0026246074,-0.019430202,-0.07178674,-0.050287154,-0.12477988,0.061824284,0.022534544,-0.05155375,0.0016248173,0.031596933,-0.03148619,-0.05091807,0.028563047,-0.047201753,0.011791258,-0.032676302,-0.055334773,0.010794769,-0.062520295,0.019715881,0.040813286,0.029747503,0.0013441503,-0.026655244,-0.09049829,0.022421215,0.0029746713,0.0871533,-0.015244924,0.06832429,-0.0251229,0.025899583,-0.004113129,-0.009244686,-0.033357047,-0.049607478,-0.07617374,-0.024722172,-0.055406373,-0.068811,-0.04179695,-0.029829811,0.05959439,0.0060976367,0.14493157,-0.015248042 +2.7.3.10,"L-Arginine can act as acceptor, but more slowly.",384,1.0,-0.042348664,-0.1464437,-0.052711923,0.012083077,0.03992619,0.0044682077,0.06903404,-0.0125805065,0.04539336,0.004044096,0.065603875,0.062449653,-0.016236918,0.056687698,-0.004065595,0.0814765,-0.00970184,-0.033635158,-0.010372514,0.016502036,-0.04118957,0.070084155,-0.02808055,-0.07784628,-0.038446646,-0.057902403,-0.06595353,-0.06241974,0.03392968,-0.12205454,0.0278497,0.010425228,0.03059113,-0.009197937,-0.060021326,0.05743217,-0.062252805,0.021500029,0.03647055,0.023603525,0.00023025386,-0.028263882,-0.0045828465,-0.012458357,-0.052186705,-0.023730457,0.018710403,0.0049782726,-0.053515002,-0.034690343,-0.0029918472,0.014805005,-0.0073187863,0.02403885,-0.12294325,0.029351013,-0.16217992,0.0003106009,0.00689249,0.021910233,-0.06295355,0.07809336,-0.01997424,0.017440105,0.024763817,-0.01934666,0.06934994,-0.06684543,0.048801813,0.074000195,0.07013173,0.003684532,-0.051795524,0.032639585,0.046547167,-0.03244128,0.0092056645,-0.009512912,0.063102946,0.010603792,-0.043446213,-0.014886607,-0.019739106,0.018226154,-0.014464637,-0.039483674,-0.067593545,0.053197537,-0.038300134,-0.020075599,0.092067,-0.051844668,-0.009635998,0.0115361195,0.065876834,-0.062520154,0.036785726,-0.019313969,-0.10758198,0.023405867,-0.037868857,0.038892277,-0.08378676,0.014790555,0.016695794,-0.025143873,0.06797482,-0.061365563,-0.07401983,-0.019526668,-0.008725948,-0.08462999,0.06963365,0.053262237,-0.06252442,0.0457005,0.01669293,-0.06277164,-0.013385139,-0.015937055,-0.029199779,0.032904577,0.02374339,0.024538584,0.0191857,0.06860735,-0.006602543,-5.268697e-34,-0.030533945,-0.02813669,-4.9803162e-05,-0.026143363,-0.032105424,0.040232617,-0.04780503,0.02077912,0.066022485,-0.049896922,-0.07979098,-0.034743246,0.03150707,0.11117366,-0.03665032,0.0070382063,0.0029092457,0.07266613,0.026497843,-0.010924203,-0.0034226787,0.05642536,-0.0431632,-0.0049687764,-0.0011311921,-0.0029667974,0.09139169,0.05524726,0.0036343539,0.019566901,-0.024341865,0.010403645,-0.011478685,0.032632407,-0.0033862514,0.041466553,0.032429546,0.00048252658,0.03415189,-0.07615932,-0.052729532,0.0777451,-0.11907958,0.028911956,-0.026335971,-0.042291302,-0.03752874,0.014040823,-0.092301406,0.03838513,0.06957748,-0.017509079,-0.054691948,-0.04652012,0.023954159,0.024708288,0.0056368806,0.11291786,0.037438743,0.04855799,0.011284214,0.03443357,0.029079633,0.041972667,-0.041540902,0.048073005,-0.030185988,-0.09383904,-0.016996609,0.02390648,-0.07891004,-0.017587014,0.027431354,-0.031243496,0.07181669,-0.07948337,-0.022131681,-0.015675569,0.03608816,-0.03813102,-0.03614833,-0.034980036,0.036640435,0.10686045,-0.009084706,-0.10349474,0.07753204,-0.07134368,0.03638233,-0.04310854,0.019478211,0.02118547,-0.020816088,0.015185822,0.047377553,1.8287924e-34,0.047016066,-0.09166533,0.048663974,0.09459712,0.023883214,0.07509303,0.057125185,0.02671612,0.09828969,0.009543017,0.09007061,0.06407387,-0.0030362185,-0.0063447934,0.07768305,-0.028710824,0.0395142,-0.009492175,0.03605724,0.05020061,-0.042055335,0.0071044313,-0.02647457,-0.015879259,-0.02889224,0.025404215,-0.062457137,-0.01514502,-0.049340244,-0.026146736,-0.047118716,-0.021298995,-0.05408985,-0.06397008,-0.0015036402,0.09131668,0.0074194456,0.06801773,-0.1327664,-0.06250454,0.031064976,-0.036365744,-0.0057584373,0.0394475,0.0069061676,-0.063023694,0.08334364,-0.08218172,-0.069426574,-0.029019272,0.011906382,-0.017046083,0.05182137,-0.014068337,0.06085349,0.01607011,0.02113726,-0.093692094,-0.05594796,0.022247007,0.0030781701,-0.077830866,0.015551545,0.04134996,0.07649297,-0.042652857,-0.031114345,0.05679655,0.061582346,-0.04716898,0.17734861,-0.033965413,0.0342914,0.16530962,0.042173926,-0.03644,0.019355804,-0.13666776,0.0014414653,-0.08248589,-0.089905806,0.00038758555,-0.0013176586,0.008955544,-0.04870498,-0.008735328,-0.03784082,-0.026717877,0.0487354,0.090922266,0.0329531,0.021589978,0.025516136,0.006128498,0.07478233,-2.0263565e-08,0.0026915334,-0.0022593087,0.036095917,0.03068988,-0.042495463,0.04619875,0.0052583744,0.013675309,-0.017957527,0.021774314,0.068757385,0.10617585,0.08067859,-0.053912908,0.06634483,0.05901559,-0.028349593,-0.026205517,-0.035336528,0.080071375,-0.088119805,0.07856027,0.017133545,-0.12700878,-0.037428208,-0.03791568,0.01130473,0.057831705,-0.0563184,-0.032452647,0.0036872046,0.03584527,0.015825478,0.03268325,0.0026545222,0.03730113,0.029156188,-0.037508756,0.010859195,0.047497205,-0.045811597,0.08121096,-0.06817227,-0.015133742,-0.02252977,-0.01348011,0.001423545,-0.07171203,-0.006686561,-0.0040654093,0.03329267,0.048134215,0.03023227,-0.035420343,0.00895508,0.010582893,-0.09029317,-0.042770535,0.041616395,-0.05992805,-0.0062883375,0.021567008,0.0513398,0.02494764 +2.7.3.11,A number of histones can act as acceptor.,384,1.0,0.033874996,0.017470405,-0.024978312,-0.050934836,-0.08120356,0.02436529,0.06774135,-0.07551067,-0.015577489,-0.0036630742,0.050688952,-0.06547527,-0.027737636,-0.023331014,0.05472306,0.02612233,-0.031674918,0.0019521567,-0.103823945,-0.008004635,-0.043085188,0.027425291,0.05755043,-0.04059876,-0.061311074,-0.043208633,-0.05101284,-0.002080475,0.06854883,-0.12039867,0.013080837,0.03241358,0.078729644,0.040532637,-0.031387873,0.004318842,-0.030346531,0.056560434,0.0097788405,-0.02380609,0.024290819,-0.015937816,-0.0004379825,0.03293393,-0.06738583,-0.049187213,-0.05779114,0.0046184584,-0.013503444,-0.064262904,0.0036187766,0.0073187375,0.017199604,-0.008079845,-0.10332456,0.029696908,-0.06296674,-0.09106646,-0.009520354,-0.07283876,-0.019907134,-0.03256822,-0.01956943,-0.009443948,0.05030016,-0.016402842,0.042953365,-0.096537426,-0.016976938,0.015038333,0.11059351,-0.027307754,0.042434726,0.046874676,0.037472047,-0.006678178,-0.047012754,-0.008328083,-0.00037712482,0.026431536,-0.06468277,-0.028646734,0.057422098,-0.010522189,0.0526677,-0.004411385,-0.081306934,0.04014022,-0.10864182,0.10234652,-0.036960755,-0.0663483,0.041530278,0.009501521,0.033355974,0.008153194,0.039882027,0.022827836,-0.04344119,0.013403701,0.04053337,-0.0023035626,-0.019884469,0.068341546,0.01969881,0.010568733,-0.01581011,-0.041015852,-0.0045347926,-0.05211262,0.026210193,-0.14224295,0.055660073,0.044861075,0.009699728,0.084065855,-0.01793953,0.039179318,0.071466394,-0.011139487,-0.033501096,0.08273684,0.02322027,0.035449743,-0.014864029,-0.03437042,-0.12097594,-3.3460513e-33,-0.014025801,0.07900424,-0.00023670743,0.017287163,0.021937655,0.0024253405,-0.12499471,0.043593116,0.10227061,-0.1184074,-0.046187744,0.027659193,0.06235727,0.06509503,-0.077134825,0.014300828,0.01946194,0.0492432,0.019438624,-0.09844215,-0.04969219,0.018463263,-0.06427153,0.0018616101,0.009510597,0.025988275,-0.0032154068,0.03346315,0.04189611,-0.005012406,0.061808925,0.0574033,0.07675717,0.092582256,0.025502175,0.08276806,0.05944682,0.027853645,-0.032001678,-0.016755449,0.015931617,-0.018266097,-0.077886544,-0.010017025,-0.042194773,-0.02573769,-0.019141069,-0.06292026,-0.07205934,0.048698023,0.007888556,0.015390155,0.010868807,-0.016080309,0.034301475,-0.033154827,0.056835283,0.024830122,0.005254196,0.031125603,-0.04596272,0.01566733,0.049498133,0.02080448,-0.010765899,-0.014707115,-0.061129067,-0.045983333,-0.09433693,0.033587154,-0.04847572,0.0025827454,-0.029303549,0.012224695,-0.051803,-0.042397086,-0.016005928,-0.046480987,-0.053808514,0.06411031,-0.0014957334,-0.018000599,-0.07364148,-0.005006847,-0.041822013,0.0032586863,0.09321258,-0.16391471,0.073729426,-0.016332299,0.03414011,-0.0074298307,0.027876373,-0.059998248,0.020545097,3.3006729e-34,-0.022870874,-0.00979643,0.02800087,0.13279283,0.035903048,0.06598332,0.084180124,0.04811571,0.0837304,-0.013788902,0.03577583,0.041700315,0.08663127,-0.079273745,0.039819695,-0.0052618976,0.02388128,0.116269276,0.060539305,0.04683395,-0.10657199,0.04013722,-0.072875164,0.060546156,-0.046826284,0.06719019,-0.035773594,-0.08468282,0.052200455,-0.006203339,0.0015677583,-0.009882278,-0.0437554,-0.037991665,0.06570922,0.023613585,-0.05410449,0.06808902,-0.057887897,0.018087385,-0.013632245,-0.043512218,0.02212301,0.059311315,0.00068718265,0.029648535,0.10636119,0.099390715,-0.07293456,-0.023672346,0.037771247,0.0027009766,0.009003903,0.005333597,0.046657376,0.055178344,0.036824785,-0.06542777,-0.029515687,0.005070951,-0.039944828,-0.045425635,0.019276774,0.0147946095,-0.021425592,0.008524807,-0.07106666,0.03440669,-0.0031349966,0.08959388,0.024728673,-0.07428683,-0.0167568,0.05647872,0.025801364,0.03313809,-0.021819046,-0.097285174,-0.030553102,-0.07333103,-0.11260507,-0.008565475,0.05842333,-0.038147397,0.03367886,-0.081370614,-0.022109922,-0.0074509624,-0.026003497,0.05319424,0.037153654,0.055427477,-0.023718193,0.005878145,0.03558692,-1.9285368e-08,0.035276853,-0.07196753,0.059586227,-0.0479649,0.024572209,0.028551199,0.10361196,-0.09296975,0.05923667,0.058576755,-0.04879656,0.041267443,0.028649425,-0.015691949,0.02445967,-0.0003484009,-0.020851891,-0.012894542,-0.03617565,-0.02297281,-0.084138334,0.036920436,0.078455605,-0.11969231,-0.04322381,0.0055129873,-0.0055992766,0.052893173,-0.052240603,-0.014378933,0.0865602,-0.018735873,0.015572989,-0.0600461,-0.010153426,-0.011846657,0.08874951,-0.06461133,0.07214833,-0.019888535,0.06537272,-0.022550466,-0.10505385,0.04571694,-0.026519932,-0.04732168,-0.00445682,-0.039044034,-0.05037734,0.021911683,-0.03607672,0.10057022,0.04132366,-0.009296327,-0.0028048796,-0.0048821275,-0.023441667,0.066712864,-0.021379344,-0.025240678,0.060513888,-0.0020593116,0.044106685,-0.08274366 +2.7.3.12,A number of histones can act as acceptor.,384,1.0,0.033874996,0.017470405,-0.024978312,-0.050934836,-0.08120356,0.02436529,0.06774135,-0.07551067,-0.015577489,-0.0036630742,0.050688952,-0.06547527,-0.027737636,-0.023331014,0.05472306,0.02612233,-0.031674918,0.0019521567,-0.103823945,-0.008004635,-0.043085188,0.027425291,0.05755043,-0.04059876,-0.061311074,-0.043208633,-0.05101284,-0.002080475,0.06854883,-0.12039867,0.013080837,0.03241358,0.078729644,0.040532637,-0.031387873,0.004318842,-0.030346531,0.056560434,0.0097788405,-0.02380609,0.024290819,-0.015937816,-0.0004379825,0.03293393,-0.06738583,-0.049187213,-0.05779114,0.0046184584,-0.013503444,-0.064262904,0.0036187766,0.0073187375,0.017199604,-0.008079845,-0.10332456,0.029696908,-0.06296674,-0.09106646,-0.009520354,-0.07283876,-0.019907134,-0.03256822,-0.01956943,-0.009443948,0.05030016,-0.016402842,0.042953365,-0.096537426,-0.016976938,0.015038333,0.11059351,-0.027307754,0.042434726,0.046874676,0.037472047,-0.006678178,-0.047012754,-0.008328083,-0.00037712482,0.026431536,-0.06468277,-0.028646734,0.057422098,-0.010522189,0.0526677,-0.004411385,-0.081306934,0.04014022,-0.10864182,0.10234652,-0.036960755,-0.0663483,0.041530278,0.009501521,0.033355974,0.008153194,0.039882027,0.022827836,-0.04344119,0.013403701,0.04053337,-0.0023035626,-0.019884469,0.068341546,0.01969881,0.010568733,-0.01581011,-0.041015852,-0.0045347926,-0.05211262,0.026210193,-0.14224295,0.055660073,0.044861075,0.009699728,0.084065855,-0.01793953,0.039179318,0.071466394,-0.011139487,-0.033501096,0.08273684,0.02322027,0.035449743,-0.014864029,-0.03437042,-0.12097594,-3.3460513e-33,-0.014025801,0.07900424,-0.00023670743,0.017287163,0.021937655,0.0024253405,-0.12499471,0.043593116,0.10227061,-0.1184074,-0.046187744,0.027659193,0.06235727,0.06509503,-0.077134825,0.014300828,0.01946194,0.0492432,0.019438624,-0.09844215,-0.04969219,0.018463263,-0.06427153,0.0018616101,0.009510597,0.025988275,-0.0032154068,0.03346315,0.04189611,-0.005012406,0.061808925,0.0574033,0.07675717,0.092582256,0.025502175,0.08276806,0.05944682,0.027853645,-0.032001678,-0.016755449,0.015931617,-0.018266097,-0.077886544,-0.010017025,-0.042194773,-0.02573769,-0.019141069,-0.06292026,-0.07205934,0.048698023,0.007888556,0.015390155,0.010868807,-0.016080309,0.034301475,-0.033154827,0.056835283,0.024830122,0.005254196,0.031125603,-0.04596272,0.01566733,0.049498133,0.02080448,-0.010765899,-0.014707115,-0.061129067,-0.045983333,-0.09433693,0.033587154,-0.04847572,0.0025827454,-0.029303549,0.012224695,-0.051803,-0.042397086,-0.016005928,-0.046480987,-0.053808514,0.06411031,-0.0014957334,-0.018000599,-0.07364148,-0.005006847,-0.041822013,0.0032586863,0.09321258,-0.16391471,0.073729426,-0.016332299,0.03414011,-0.0074298307,0.027876373,-0.059998248,0.020545097,3.3006729e-34,-0.022870874,-0.00979643,0.02800087,0.13279283,0.035903048,0.06598332,0.084180124,0.04811571,0.0837304,-0.013788902,0.03577583,0.041700315,0.08663127,-0.079273745,0.039819695,-0.0052618976,0.02388128,0.116269276,0.060539305,0.04683395,-0.10657199,0.04013722,-0.072875164,0.060546156,-0.046826284,0.06719019,-0.035773594,-0.08468282,0.052200455,-0.006203339,0.0015677583,-0.009882278,-0.0437554,-0.037991665,0.06570922,0.023613585,-0.05410449,0.06808902,-0.057887897,0.018087385,-0.013632245,-0.043512218,0.02212301,0.059311315,0.00068718265,0.029648535,0.10636119,0.099390715,-0.07293456,-0.023672346,0.037771247,0.0027009766,0.009003903,0.005333597,0.046657376,0.055178344,0.036824785,-0.06542777,-0.029515687,0.005070951,-0.039944828,-0.045425635,0.019276774,0.0147946095,-0.021425592,0.008524807,-0.07106666,0.03440669,-0.0031349966,0.08959388,0.024728673,-0.07428683,-0.0167568,0.05647872,0.025801364,0.03313809,-0.021819046,-0.097285174,-0.030553102,-0.07333103,-0.11260507,-0.008565475,0.05842333,-0.038147397,0.03367886,-0.081370614,-0.022109922,-0.0074509624,-0.026003497,0.05319424,0.037153654,0.055427477,-0.023718193,0.005878145,0.03558692,-1.9285368e-08,0.035276853,-0.07196753,0.059586227,-0.0479649,0.024572209,0.028551199,0.10361196,-0.09296975,0.05923667,0.058576755,-0.04879656,0.041267443,0.028649425,-0.015691949,0.02445967,-0.0003484009,-0.020851891,-0.012894542,-0.03617565,-0.02297281,-0.084138334,0.036920436,0.078455605,-0.11969231,-0.04322381,0.0055129873,-0.0055992766,0.052893173,-0.052240603,-0.014378933,0.0865602,-0.018735873,0.015572989,-0.0600461,-0.010153426,-0.011846657,0.08874951,-0.06461133,0.07214833,-0.019888535,0.06537272,-0.022550466,-0.10505385,0.04571694,-0.026519932,-0.04732168,-0.00445682,-0.039044034,-0.05037734,0.021911683,-0.03607672,0.10057022,0.04132366,-0.009296327,-0.0028048796,-0.0048821275,-0.023441667,0.066712864,-0.021379344,-0.025240678,0.060513888,-0.0020593116,0.044106685,-0.08274366 +2.7.4.1,"The enzyme is responsible for the synthesis of most of the cellular polyphosphate, using the terminal phosphate of ATP as substrate.",384,1.0,-0.034928855,0.014127228,-0.01001806,-0.06395017,-0.05011287,0.021483213,0.008966466,0.010220784,0.069257185,0.0894138,0.012141999,0.026914984,-0.006759675,-0.0059039574,-0.051850714,-0.054677345,-0.026242629,0.06583609,0.06961492,-0.05263133,0.13963637,0.019463684,-0.018174019,-0.051598024,0.038456224,0.020038523,0.08024752,-0.03401756,-0.006796645,-0.01570745,-0.12896517,-0.013719572,0.03781956,-0.061679646,-0.027637867,0.14971529,-0.07542978,-0.02317127,0.02538368,-0.024617925,0.09514264,-0.013205504,0.001372361,-0.007971684,-0.0759907,-0.0016135873,0.062280957,0.014110956,0.01945475,-0.0065654,-0.022219766,-0.050179716,-0.03924533,-0.0649958,0.019686481,0.026340714,-0.0064184633,0.043850176,-0.017759193,-0.012352785,-0.02736159,0.010762258,-0.035590753,0.05079361,0.11102091,-0.075544804,0.07135142,-0.00057961076,-0.040350646,-0.021867983,-0.027148882,0.013845898,0.020255547,-0.00620196,-0.034755535,0.032004032,-0.011246086,0.0132110305,0.015465572,-0.001373151,0.11699232,-0.00060538296,0.0057365065,0.03244133,0.049727034,0.016087098,0.015373849,0.03385094,0.025914235,0.005383333,-0.019667858,-0.016363034,-0.0075981137,-0.03786154,-0.05855329,0.060103916,0.010621018,0.02080099,0.04069782,-0.035694182,0.08768749,0.06857108,0.05422434,-0.03149444,0.0067930566,0.03021462,-0.08060096,0.047127713,-0.009481158,0.052891325,-0.042885866,0.011412643,0.022824343,0.031735178,0.0067924606,0.10400343,-0.03121466,-0.028166918,-0.05379923,0.014679587,-0.01157081,-0.06538244,-0.035285752,0.09329149,-0.1030375,0.019306269,-0.065986246,-4.101339e-33,0.049212884,0.057392303,0.03874124,-0.03606357,-0.0069379853,0.014514393,-0.014195876,-0.048146214,-0.07428111,-0.07149777,-0.029078277,-0.102629684,0.04491963,0.026728345,-0.010045298,-0.04859625,-0.045305606,0.099246815,0.09487598,0.013932064,-0.0054302397,0.012678526,-0.017866734,-0.029891584,-0.026887082,0.038949616,-0.05663452,0.0021516893,-0.0019157017,-0.024181586,0.0002888383,-0.086119756,-0.063097045,0.015951581,0.029866079,-0.105681606,-0.07543517,-0.07620646,-0.00048629314,-0.0012680165,-0.051265083,-0.035385355,0.023996675,0.0121436715,0.01694924,-0.04830613,-0.059927445,0.013961504,0.040942416,0.093054764,0.042923886,-0.052614782,0.10490648,-0.04797156,-0.078169495,-0.0063277874,-0.04490944,-0.06781336,-0.012256261,0.052747607,0.049235377,0.031990316,-0.0602527,0.063418865,0.009757009,0.021850567,-0.06450548,-0.08474156,0.028402664,0.11255661,-0.005224779,-0.062818356,0.027654534,0.030568833,-0.010816785,0.032498434,-0.04056935,0.0440306,-0.066074535,0.048014943,0.03659741,-0.02179108,-0.05467775,-0.03351311,-0.04002409,-0.015149075,0.047977287,-0.045889594,-0.023936808,0.0405001,0.07259166,-0.07746088,-0.08901375,0.055143707,0.0049271574,6.7818255e-34,0.12238158,-0.037528202,0.06700978,-0.12266292,-0.11630999,0.0015664088,0.061904293,-0.10371553,0.01558827,-0.0028018293,-0.06459818,-0.022103343,0.010133065,-0.060658332,-0.06173777,-0.014837876,0.012318379,0.04925401,0.001706496,-0.017499981,0.004114315,0.09672414,0.061839256,0.07037812,0.029693913,-0.075022735,-0.021121154,0.072576836,-0.024194205,0.07492222,-0.014915994,-0.027513504,-0.026421998,0.03431315,-0.037280772,0.03400458,-0.037117653,-0.0029419546,0.081352785,0.029280178,0.037865646,0.095779575,0.042378824,0.015569483,0.018521996,0.03745237,0.007608603,0.05103186,-0.022533437,-0.11514911,0.008574836,0.052424554,0.02035863,0.032729466,0.054840796,0.053005546,-0.020956656,0.050497245,0.011993315,-0.05759141,-0.05876585,-0.06560042,0.057965543,-0.064399466,0.02322437,0.09697155,-0.01604748,0.021000568,-0.04214196,0.04080773,0.019167567,0.050035205,-0.023545394,0.0561635,-0.006345651,-0.01345862,-0.061693184,-0.008141914,-0.015959738,-0.04306651,-0.019450694,0.06213327,-0.08991853,-0.060397904,-0.025096055,-0.03804547,0.052211925,0.081373766,0.0030351763,-0.014591974,0.0011096982,-0.021916019,-0.057515226,0.04113883,0.043936417,-2.4846457e-08,0.03222575,-0.026350936,0.037436467,-0.06585495,-0.006355706,0.038080122,0.07452086,-0.020566266,0.086007856,-0.049061593,-0.03455214,0.023542346,0.053186428,0.018225117,0.072996035,0.028579026,-0.0858357,0.04626354,-0.042192105,-0.06254858,-0.000571417,-0.027571686,-0.115271986,0.118717395,0.08337185,-0.01396814,0.033307444,0.0058984715,-0.024452014,0.015435059,0.020286456,-0.045734238,-0.0359563,-0.067706704,-0.019113295,0.065896675,-0.036198523,-0.0011246476,-0.0053581055,0.0037313758,-0.03767144,-0.051066168,0.015456234,0.047982693,-0.0091580525,0.07387628,-0.023288941,0.03801311,-0.027090337,0.0028052654,0.0001173487,-0.019956047,-0.045677464,-0.13510497,-0.054501098,-0.055685442,-0.022874696,-0.058790933,-0.0047181053,-0.010823809,0.048106756,0.07991555,0.18303019,-0.06802413 +2.7.4.3,Inorganic triphosphate can also act as donor.,384,0.99999994,-0.07513926,-0.027944397,0.010870338,-0.033928584,0.057401795,-0.059561543,0.11643879,0.07717565,0.013816628,0.032195184,0.011142257,-0.04353998,-0.04274048,0.088674195,0.011673698,-0.04335027,0.011564277,0.028989337,-0.0016648556,0.05543578,0.06297548,-0.025743164,0.00021960803,-0.06002038,-0.01978672,0.116323315,0.01510613,-0.013865833,0.062943324,-0.015616,-0.10215225,0.03693217,-0.023900209,-0.0819423,0.008565165,0.115457,-0.02336092,0.016418599,-0.06575737,0.023813134,0.07140741,-0.04602911,0.08261469,-0.0063892407,-0.023455689,-0.033540063,0.052226633,-0.014560425,-0.019375373,-0.0022964429,0.0050087385,0.0069173523,-0.03431987,0.05756513,-0.026885666,0.037056234,-0.017176442,0.03429264,-0.052753814,-0.006566654,0.013200098,-0.0035733224,0.0024478664,-0.033977386,0.1424354,-0.036627624,0.054374672,-0.015233048,0.024832722,-0.016726049,0.015096381,0.012535832,0.051114265,-0.017447183,0.016040685,0.09718769,0.011785552,0.0076778354,0.017888663,0.0050231507,0.01279717,0.022230342,0.02620608,-6.3253865e-05,0.02679867,0.032195263,-0.061840054,0.03321742,-0.06860236,0.023172978,-0.03825455,0.051628433,0.028212996,-0.03370112,-0.10049033,0.047904816,-0.033684295,0.019863302,0.033445887,-0.030288484,0.043538272,0.09821685,-0.0509862,-0.09983408,-0.02397986,0.005715985,-0.039719306,0.008043598,0.06586754,0.065714605,-0.05404129,0.02119879,0.07846557,0.027454918,-0.03672982,0.11611818,-0.051125858,-0.04580994,-0.087763116,-0.044911567,0.01630137,-0.09411966,-0.037930258,0.02660665,-0.06375434,-0.024957722,-0.065675445,-1.746886e-33,0.028794378,0.07926791,0.07430776,0.001117162,-0.085062884,0.018115675,-0.029348625,-0.06768454,-0.08308563,-0.0508675,-0.03680101,-0.049048286,0.09551541,0.04584585,-0.09186549,0.0040703714,-0.075440824,-0.03103425,0.15202086,-0.011538058,0.052868154,0.075745195,-0.06285419,0.046860885,0.06877663,-0.021809181,-0.028846668,-0.026441254,0.005166177,-0.028279899,0.10723347,-0.04659624,-0.06418484,-0.013251773,0.032223184,-0.049038347,-0.0063313027,-0.031672653,-0.03393271,-0.061171412,-0.029276835,-0.05588692,-0.0062699104,0.07745247,0.069169834,-0.0921792,-0.0560922,-0.044780362,-0.043408524,-0.021601276,-0.009683966,-0.04977421,0.045943238,-0.07348959,-0.07514867,-0.0008214623,0.0058141355,-0.0045933975,0.010390254,0.041532993,0.052552022,0.044490665,-0.052607264,0.06087803,0.015160042,0.03831349,0.025416156,-0.05233666,-0.020836398,0.013726187,-0.009171325,-0.048914246,-0.030942624,0.044620145,-0.035556275,-0.040761877,0.02360246,-0.012063922,0.07836962,0.04607542,0.022762287,-0.09110696,0.020481026,-0.038478237,-0.06299257,-0.028905556,0.00089016615,-0.12804449,0.024960404,-0.06442085,0.11429357,-0.09568664,-0.100546144,-0.099956445,-0.02023254,-4.3527063e-34,0.102063194,-0.03624617,-0.045805052,-0.016067209,-0.0022717176,-0.02360243,0.056070786,-0.07166491,0.104162484,0.0143499235,0.047718674,-0.012640787,0.055554416,-0.03897681,-0.015256317,0.063467,-0.06956707,0.031028613,0.028564187,-0.036705784,0.002809657,0.1259483,0.048705567,0.06424983,-0.020719469,0.039642747,-0.019544097,0.011175467,0.03364747,0.06382668,0.027843123,-0.017454311,-0.117446944,-0.07670416,-0.02446262,-0.006429112,0.0020245286,-0.043673884,-0.009664981,-0.022994181,0.0023361146,-0.007000723,0.122651905,0.060628325,-0.024753604,0.015130946,-0.008258494,0.044371434,0.012481434,-0.0062877242,0.024772644,0.05795351,-0.06546716,0.016419766,0.073995166,0.039085377,0.041762996,-0.012220349,-0.06958492,-0.04360199,0.0051011425,-0.03442803,-0.0029561708,-0.018743653,0.009924675,0.07756733,0.0453317,0.02404433,0.018009182,-0.012296822,0.064378515,0.031267088,0.019050812,-0.013104431,-0.012242399,-0.0017290926,-0.021840936,0.041833576,-0.039877407,-0.045810927,-0.0054885577,0.022749089,0.022310035,-0.036118295,0.1246483,-0.057780217,-0.0021163984,0.058017578,-0.024955008,-0.00050778425,-0.04989799,-0.06356977,0.016956,0.08699644,0.05820577,-1.783539e-08,0.016228879,0.03923489,0.030792294,-0.068251096,-0.042186003,-0.012123851,0.047225762,-0.011061337,0.0061564366,0.04339896,-0.071218885,0.0036936877,0.06868642,0.014575376,0.09862017,0.030081363,-0.013291373,0.003956413,-0.093733,-0.1186097,-0.005069444,-0.06494444,-0.042695425,0.09590266,0.013599766,0.035347123,0.05353996,-0.023593768,-0.018315941,-0.043634076,0.00478384,0.008530744,-0.06830063,-0.017997924,0.014060889,0.0628762,0.043896403,-0.014203597,-0.057224877,-0.03580296,-0.07319891,-0.03004331,-0.08935028,0.043996226,0.0019341945,0.016608603,-0.00901015,0.037981316,0.03926637,0.00981451,0.027991056,-0.045860242,-0.03226336,-0.050058067,-0.046398435,0.057479795,-0.020855896,0.028452288,0.11732704,-0.007956914,0.033872716,-0.007479615,0.10976358,-0.082718514 +2.7.4.4,Many nucleotides can act as acceptors; other nucleoside triphosphates can act instead of ATP.,384,0.99999994,-0.055998612,-0.08519986,-0.005941325,-0.059618592,-0.02452215,-0.025855202,0.034560557,-0.013858667,0.03962335,0.05298049,0.036278713,0.024711477,-0.09509678,0.0889474,0.036988676,0.017717632,-0.06872571,0.07113412,0.07504124,-0.0075625125,0.036843378,0.0597281,-0.02263061,-0.03641931,-0.08922432,0.0538332,0.010237672,-0.0018255812,-0.01768071,-0.083677016,-0.10550885,-0.026989061,0.01666999,0.009536729,-0.026302427,0.09847864,-0.10712767,0.032574084,-0.0016508289,-0.008277163,0.088817686,-0.0092172185,0.03256612,0.08912649,-0.09732813,-0.030011982,-0.025173096,0.026732504,0.026131015,0.00076631614,-0.013912033,0.03700216,-0.016973296,-0.021741318,-0.028028566,0.06251175,-0.06909751,-0.0066494676,-0.033443205,-0.021625282,-0.031572666,-0.06193772,-0.027801925,-0.01922605,0.13031636,-0.0535553,0.04908833,-0.006957556,-0.046583645,0.02312893,0.05500107,-0.028201815,-0.029585835,0.030596998,0.021480164,0.011434209,-0.06191633,0.017413143,0.0347982,0.059411086,-0.044442814,0.007952386,0.040582005,-0.03596923,0.049805954,-0.030736327,-0.07457383,0.08665695,-0.024115715,0.0736143,-0.0031945175,-0.005560308,0.09385746,-0.041780878,-0.015985077,-0.017865011,0.04003894,0.04826132,-0.006561861,-0.04659697,0.065475866,0.088813975,-0.06931057,-0.021489743,-0.0012583203,0.064099625,0.0021471852,-0.06832972,-0.009698412,0.054853354,-0.06841657,-0.04106688,0.06018544,-0.0040791403,-0.042809017,0.01896331,-0.047816567,-0.044592477,-0.02059831,-0.03466156,-0.07315927,-0.07674702,-0.02233073,0.016327685,-0.037377417,0.01662108,-0.027502881,1.1353164e-33,-0.009939916,-0.039732996,0.012328831,-0.0065780063,-0.044638183,0.02100304,-0.015325149,-0.008718014,-0.06797418,-0.06323918,-0.028892858,-0.0960067,0.12189904,0.048232432,-0.027999235,0.019956479,-0.016644578,0.08650648,0.0766078,-0.06790686,0.02249184,0.07086856,-0.01177344,-0.019976499,-0.007918778,0.014975327,-0.08354169,0.050468635,0.07743628,-0.040390164,0.08746994,-0.071711004,-0.05574618,0.05152348,0.07289243,-0.03350343,0.024016457,-0.016327057,0.013958627,-0.087186165,-0.122684106,0.018765828,-0.081537746,0.02809479,0.029421374,0.015993059,0.0024377564,-0.05969951,-0.058882087,0.020258121,0.051868804,-0.08861931,0.05473882,-0.07524888,0.03853071,-0.053739626,0.028822,0.037127107,-0.06872141,0.0460559,0.058112938,0.035064187,-0.0051744524,-0.009919445,0.013242787,0.03072042,-0.06938251,-0.095395744,0.012492906,0.09678943,0.018960435,-0.06305019,-0.024131248,-0.015712017,-0.012391405,-0.0066346424,-0.0061690453,-0.005721151,-0.03884682,0.10347132,-0.010878755,-0.07260533,-0.0180011,0.020459648,-0.048831675,-0.008817055,0.060259607,-0.112842776,0.05752443,-0.015858846,0.13892816,-0.029982712,-0.060545173,0.0092351325,0.093075044,-3.995909e-33,0.047874067,-0.027232446,0.026419032,0.008115202,-0.06842398,0.033834063,0.0020961047,-0.10911913,0.045168377,-0.057149958,0.018844286,-0.014524775,-0.026183948,-0.031825803,-0.022208912,0.005935001,-0.03618387,0.114153884,-0.046238326,0.032004584,-0.048566658,0.13000122,0.023730231,0.054333884,0.00085721724,0.017875269,-0.0363035,0.021293035,0.05959158,0.013253043,-0.08659268,0.028779084,-0.02874513,-0.018759914,0.05995649,0.0070315865,-0.03349512,0.06481452,-0.008175303,-0.013728059,0.038100418,0.07683918,0.042952795,0.045480493,0.004759278,-0.0032258038,0.05693798,0.05286794,-0.098101944,-0.053955954,0.029526332,0.031612024,-0.0008951929,0.004500502,0.12330651,0.05654879,0.015180913,-0.06582278,0.04621987,-0.030518958,-0.06538413,-0.09224291,0.004600175,-0.02411617,0.022452813,0.006879633,-0.10056868,0.032190222,-0.008067894,-0.027057314,-0.015124991,0.016517214,0.037854813,0.03627557,0.029525764,0.01088388,-0.021756502,-0.026863018,-0.033702634,-0.03300646,-0.06735848,0.07457305,-0.051965766,-0.034412876,0.041411247,-0.0049777403,0.073470876,-0.0059389775,-0.035412278,0.011635063,0.05499134,0.0027949212,0.06631112,0.07117163,-0.00040037668,-2.6901477e-08,0.048260674,-0.0030872356,0.073457904,-0.08482804,0.0034173848,0.023273729,0.0073841754,0.02391815,0.062770024,0.081696294,0.004504794,0.05591869,0.061433714,0.0048492034,0.16139871,0.04753497,-0.093845055,-0.00790159,-0.04610727,0.0006759916,-0.07150335,-0.03643529,-0.106632434,0.08055552,-0.007994943,0.033999123,0.022015335,0.01552557,-0.02076709,-0.04507411,0.051883712,-0.05505778,0.0473514,-0.046641067,0.011283322,0.012913861,0.046318643,-0.023978112,-0.06512956,-0.04137007,-0.063265994,-0.045827057,-0.109788686,0.061163235,-0.042111605,0.047307037,-0.026078923,0.019669399,-0.07333898,-0.005904091,-0.0063040564,-0.03467709,0.027339607,-0.066887155,-0.00086374185,-0.014479517,-0.027899899,-0.014493715,-0.010413925,0.009565221,0.050577328,-0.0020383496,0.11286791,-0.028085144 +2.7.4.6,"Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.",384,1.0,-0.07661037,-0.07393496,0.012604421,-0.086996555,0.024584671,-0.035097513,0.050656352,0.056033447,0.04104577,0.03189362,0.029697847,-0.00037015995,-0.052004527,0.08152652,-0.02532203,0.0271638,-0.037797444,0.036024746,0.062382642,0.049496338,0.0042133303,-0.0065028816,-0.030904977,-0.04490943,0.004318164,0.026455566,0.007865595,0.008221921,-0.005611002,-0.08752271,-0.073980205,4.102036e-05,-0.005181872,-0.03051944,0.029669907,0.11718545,-0.07983704,-0.0056530065,-0.021065047,0.041255057,0.06394045,-0.035332367,0.06938053,0.03006006,-0.09044903,-0.0044310614,0.0048138136,0.074779965,0.033981908,-0.0048641236,0.022566296,0.016738988,-0.0185055,0.014218818,0.0024774678,0.049718488,-0.042673923,0.010063189,-0.02350751,-0.021900827,-0.04564212,-0.048256278,-0.026767254,-0.035276055,0.14481278,-0.019084051,0.06841807,0.012525879,-0.00905495,-0.0029941096,0.05183312,0.0029386634,0.018409528,0.0074676545,0.03438684,0.099731535,-0.03021603,0.012132658,0.031210255,-0.0035056048,-0.051395826,-0.016937751,0.05653152,-0.051815845,0.042738844,0.030866358,-0.115956694,0.05528481,-0.006285514,0.058164835,0.0015707633,0.032800708,0.056433417,-0.078810625,-0.037507683,0.042513818,0.0093053095,0.07557739,-0.0363031,-0.02587752,0.03775757,0.0805328,-0.06974735,-0.075421356,0.019601764,0.03076695,-0.0068732137,-0.096835665,0.012775405,0.031389013,-0.04137678,-0.025273237,0.044397287,-0.0030345726,-0.05062793,0.046712693,-0.02661271,-0.048214298,-0.032855563,-0.08104442,-0.046681292,-0.043174963,0.012662566,0.043741077,-0.04866475,0.043863878,-0.08794905,4.5441772e-33,0.030182283,0.02846669,0.028307637,0.047896292,-0.0869076,0.024455838,-0.039447475,-0.03755999,-0.06178801,-0.042474736,-0.13718143,-0.06724486,0.14932097,0.025553746,-0.05181757,-0.031154007,-0.040217448,0.02742524,0.061089963,-0.011262749,0.03650321,0.08018999,-0.031950593,0.054663584,0.008777181,0.0009766995,-0.10274665,0.04070561,0.0507416,-0.047749463,0.09008093,-0.042635147,-0.043814544,0.014041777,0.0168441,-0.05182592,0.002939516,-0.03217496,-0.012280817,-0.073375635,-0.027814992,-0.013218554,-0.06627845,0.032761272,0.051348362,-0.06741447,0.005712511,-0.098627776,-0.08750014,0.009950388,0.037926916,-0.078836404,0.030984199,-0.09812929,-0.0035425718,-0.05738285,0.03258489,0.012793239,0.026335223,0.048272718,0.037788365,0.029235426,-0.016462617,-0.025107045,-0.014013193,0.04683684,-0.03340079,-0.08654288,0.0069454927,0.0670576,0.034100045,-0.05116254,-0.05198207,0.013490711,-0.013900416,-0.0172185,-0.02681976,0.0022496718,0.008769455,0.042433266,0.036345668,-0.0864737,-0.021928534,-0.00948192,-0.061803166,-0.006602242,0.042196084,-0.16065212,0.05758207,-0.00688548,0.07494211,-0.044054106,-0.045352936,-0.09014011,0.06817021,-5.5401434e-33,0.09455986,-0.046911478,0.010085296,-0.027953671,-0.05054499,0.027883543,0.029278072,-0.15283613,0.1132956,-0.033306863,0.0491013,-0.027826592,0.057551865,-0.050203312,-0.0341336,0.05337893,-0.05613716,0.037836283,0.0105561,0.013469295,-0.04680415,0.10867184,0.078024745,0.038501106,-0.028598184,0.016018435,-0.014987222,-0.016643697,0.07147345,0.012635233,-0.057895802,0.028347569,-0.042882744,-0.03866366,0.014194724,0.0402492,-0.064283654,0.028535351,0.038124792,-0.021447683,-0.008305653,0.04072884,0.047996245,0.083469406,-0.040277384,-0.015075313,0.007665976,0.014684568,-0.053876374,-0.06779275,-0.012387016,0.026281973,0.014055341,0.058431,0.07717327,0.060188465,0.050516173,-0.010244548,0.036744844,-0.016671076,-0.03974044,-0.06776477,-0.0054256627,-0.010569181,0.009055456,0.06632099,-0.019290986,0.02610068,-0.005411406,-0.0065528257,0.027333507,0.0062005776,0.036168784,0.017588288,0.004623727,-0.014777353,-0.04369022,0.026632192,-0.0058655124,-0.09423566,-0.10446382,0.056976277,-0.025814038,-0.006470955,0.08329699,-0.060749013,0.07084776,0.02235542,-0.039001517,0.02530181,0.012015546,-0.019160276,0.114625156,0.124533005,0.094248556,-3.2755782e-08,0.050270222,0.01885507,0.0147817945,-0.07026349,-0.019789498,0.005193308,0.0045776498,0.00045759237,-0.0046637943,0.0519642,0.0039207656,0.06433772,0.021833139,-0.0097242305,0.16000482,0.05676478,-0.08802972,-0.0101578925,-0.062855616,-0.026718087,0.010804429,-0.019812822,-0.04807132,0.07150047,-0.031384088,0.07152209,0.06420002,-0.007769473,0.010683708,-0.042775523,0.029691868,-0.017473744,-0.022587229,-0.11317721,0.06527018,0.07994501,0.020459903,-0.005245926,-0.007553953,0.027301988,-0.083365925,-0.060042974,-0.12857918,0.029924057,-0.058400013,0.035500105,-0.0020310234,0.040851153,-0.034849133,0.043708503,0.022468697,-0.032983996,0.025181163,-0.05332005,-0.060624752,0.0024890937,-0.029215328,0.025930623,0.097238794,-0.017579213,0.0017919606,0.01287501,0.08215816,-0.071792915 +2.7.4.8,"dGMP can also act as acceptor, and dATP can act as donor.",384,0.99999994,-0.1623705,-0.01605793,0.0045099733,-0.057804853,-0.005406248,-0.048079617,0.0872901,0.068046555,0.008273613,0.049333543,0.034081183,0.017557396,-0.05815112,0.097228415,0.030010523,0.034609567,-0.012292734,0.029685833,0.048201885,0.040163804,-0.031977806,-0.018539475,-0.010864148,-0.06158261,0.012594079,0.01953138,-0.023906687,0.051222865,0.037211962,-0.021221513,-0.043244757,0.005643157,-0.03224646,0.030904185,-0.019744165,0.11129168,-0.016537962,0.06513411,-0.07513806,-0.054024037,0.047706433,0.006481385,0.01930133,0.0038321025,-0.041025296,0.03735628,-0.038469955,0.10327085,-0.09889887,-0.085046895,0.02716471,0.02907245,0.02415618,0.12183046,-0.05395313,0.043853607,-0.0030749955,-0.0012282046,-0.058438845,-0.024982017,-0.10160215,0.02616729,-0.024092946,-0.022283077,0.1301981,0.0066549676,0.030392643,0.022450967,0.052616253,-0.0073845387,0.02414378,-0.036233224,-0.020457191,0.036373522,0.025310729,-0.0090776,0.020808803,-0.034294657,0.09692416,0.009187735,-0.031849306,0.12850861,0.02006948,-0.010779512,0.010299612,0.012162929,-0.10784164,-0.039118234,-0.04229111,0.0021048414,-0.032881256,-0.019723702,-0.04468599,-0.0247707,-0.013722486,-0.02172358,0.01819016,0.009450421,0.024364466,0.0033605688,-0.026451372,0.032246485,-0.06881845,-0.041321903,-0.03817017,-0.055514712,0.02192748,-0.10532735,-0.01910801,-0.008128578,-0.006648074,-0.003040102,0.06218994,0.037318833,-0.025376284,0.02630498,-0.08734228,-0.020208897,-0.024486702,-0.0837824,-0.10272899,-0.057168715,0.021910582,0.011147505,-0.055162404,-0.006108959,-0.018780801,-1.8021531e-35,-0.012163216,-0.023450818,-0.0124905715,-0.015234578,-0.011577306,0.06846108,-0.033917107,0.012683217,-0.050581157,-0.067516185,-0.08006687,-0.08595347,0.07125352,0.119293995,-0.092582144,-0.017638093,-0.019040152,0.10668995,0.023485271,-0.027998501,0.07147811,0.11551922,-0.03917706,0.016492832,0.076037705,0.031127052,-0.0542674,0.06462275,0.1129308,0.0017936662,0.009847342,-0.032352034,-0.0071436088,0.07259164,-0.04063596,0.06449255,0.010129576,-0.07175345,-0.022640802,-0.05980945,0.008447311,-0.010358356,-0.08375566,0.03957121,-0.03576296,0.035655774,0.029287187,-0.11363283,-0.09717598,-0.00067479204,0.041032456,-0.015518025,-0.018460117,-0.15758938,-0.0044411095,-0.019229973,-0.009140069,-0.007958215,0.011547666,0.06841178,-0.027926814,0.038033657,-0.023051169,-0.029506773,-0.0057951827,-0.024649505,0.019920183,-0.1305195,0.039921045,0.05982223,-0.036067512,0.033453736,-0.010131657,0.076055914,-0.0062101223,-0.03555699,0.0036209037,0.10347888,0.069955744,0.062033087,-0.12069072,-0.013826694,-0.06143936,0.0603475,0.035011675,0.0017985528,0.017323686,-0.0866226,0.0061668037,-0.067400984,0.029452771,-0.0001437279,-0.022399167,-0.018468432,0.03356199,-2.1494585e-33,-0.04360844,0.016809024,-0.027962038,0.070094675,0.040975057,0.021177141,0.021888757,-0.06037712,0.16076985,0.027154647,0.0573726,-0.073789276,0.008267577,0.01860067,0.027758205,-0.026384927,-0.07604328,0.046036,-0.088181816,0.063029535,0.04551389,0.0911299,0.010330698,0.013645372,0.0025741968,0.022427218,-0.052937716,0.028118143,0.03592968,-0.0042057796,0.015742118,0.074288756,-0.14886217,-0.024631867,0.005097143,0.017845402,-0.060288724,0.003988965,-0.10941705,-0.052010484,0.048438493,0.033844788,-0.008954264,0.13153729,-0.018424543,-0.016189842,0.07567463,0.05186357,0.03263001,-0.03534601,-0.031915925,-0.0019624026,0.060983535,0.0053149406,0.023388917,0.04136083,0.086551264,-0.018194076,-0.009833061,-0.013499632,9.5046904e-05,-0.07344983,0.015999766,0.057684228,0.020817913,-0.0148003055,0.06310702,-0.037959814,0.022306701,-0.002785758,0.09765786,-0.041693863,0.05320765,-0.002031962,0.006453992,-0.0380546,-0.09872546,0.01857633,0.043493558,-0.04502918,-0.07284478,0.00038067892,0.073592596,0.057713404,0.030564586,-0.029600684,-0.012242316,-0.019158129,0.002586671,0.058174215,-0.03723857,-0.022097908,-0.0061317,0.023913527,-0.0034101869,-2.3436826e-08,0.04071039,-0.001810877,0.0034357358,-0.029495789,-0.030588176,-0.01229912,-0.06197843,-0.0021917962,0.034961477,0.10087132,0.010604679,0.086105615,-0.054066814,-0.073559836,0.05498093,-0.01437817,0.04390825,-0.01313619,-0.0765154,-0.030249007,-0.079492375,0.0021434212,-0.012452234,0.03751527,0.0049830764,0.05988427,0.027646517,0.04853242,0.0345212,-0.030284537,0.028941335,0.0145215485,-0.03709212,0.029883359,0.04402292,0.019093694,0.047714267,-0.036838263,-0.008518196,0.035204716,0.02284491,-0.064869694,-0.023360886,0.06094995,-0.10606989,0.04700602,-0.009403096,-0.038926728,-0.063947275,-0.018626101,0.031215802,-0.07334436,0.03187213,-0.036860168,-0.07191666,0.016083386,-0.016541352,0.015962599,0.030162646,-0.0130256945,-0.000610875,0.073815145,0.06976195,-0.015057869 +2.7.4.10,Many nucleoside triphosphates can act as donors.,384,1.0,-0.061698154,-0.014642909,0.0016286037,-0.064039566,0.020881196,-0.025957735,0.06542371,0.07964899,0.010730038,0.037641186,0.013531311,-0.03683643,-0.06390194,0.08619872,-0.021734893,-0.0033546041,-0.041252308,0.04956773,0.039599113,0.0017985394,0.041517437,0.0018558617,0.022385495,-0.029328424,-0.004311459,0.074108034,0.022534614,-0.007183277,0.024996696,-0.06236163,-0.07413432,-0.0019075414,-0.007556364,-0.040314253,0.05150329,0.12601326,-0.06405521,0.027046679,-0.038936954,0.016407521,0.08614895,-0.0414983,0.08546388,0.030863332,-0.07780183,-0.005922687,-0.0135614965,0.039435446,0.035798166,0.04403236,0.040684573,-0.02790087,-0.008120981,0.02146292,0.030474352,0.014111269,-0.03673578,0.010241685,-0.018640427,0.015399413,0.0031081156,-0.032964163,-0.011642042,-0.042902548,0.14542651,-0.0071223783,0.096266806,0.017739307,0.017716376,0.00997073,0.051784914,-0.0035107515,0.028627813,0.028053034,-0.01643322,0.09166163,0.005817059,-0.009473215,0.016569613,0.0013075136,-0.022456864,0.008793067,0.08973692,-0.022503652,0.06032607,0.026018491,-0.10833838,0.033395972,-0.02121689,0.06318533,-0.027446376,0.053238057,0.049533613,-0.06334542,-0.06459757,0.055536706,-0.05282524,0.048474565,-0.018733293,-0.016559979,0.05706972,0.0887411,-0.021775056,-0.08162749,0.021058798,0.035511408,-0.03559005,-0.08132576,0.026631966,0.0773447,-0.011953832,0.034842912,0.048031643,0.004992656,-0.048500128,0.06311944,-0.070726134,-0.007530099,-0.09185488,-0.033308517,-0.00047265805,-0.07552536,-0.01935159,0.014662362,-0.06451597,0.0024488003,-0.09102572,3.2591883e-34,0.06241933,0.04618794,0.0054467036,0.05790029,-0.085768044,0.026779529,-0.007210171,-0.056532837,-0.09371668,-0.03974339,-0.072993204,-0.08154782,0.12327407,0.014022401,-0.095027775,-0.020520331,-0.041884392,0.007146331,0.07073441,-0.017129093,0.009878623,0.04766053,-0.0099447,0.039733037,0.063240804,-0.004923698,-0.11360989,0.0333245,0.08014503,-0.04476038,0.07253742,-0.029754804,-0.046727624,-0.013526428,0.037960336,-0.033360247,-0.0028604807,-0.042696208,-0.021908008,-0.034357764,-0.018576732,-0.00063599704,-0.013165227,0.021305982,0.039888013,-0.05159205,-0.017597089,-0.056026522,-0.068001896,-0.0001059847,-0.006793583,-0.08277279,0.03545384,-0.06304729,-0.022879332,-0.06389125,0.011753754,-0.022306776,0.0076150307,0.030795591,0.05237258,0.045778032,-0.0008324046,7.2843635e-05,-0.0042636306,0.05351657,-0.033800848,-0.06796896,-0.022829553,0.03892697,0.026506826,-0.0733564,-0.04853402,-0.017893754,-0.040136818,-0.03130466,0.01156597,0.0031034537,0.029585183,0.04259118,0.061834093,-0.08156825,0.024904115,-0.019447159,-0.04777038,-0.016299158,0.001954022,-0.13685584,0.040004637,-0.078274794,0.12640443,-0.08080781,-0.03869053,-0.10926708,-0.036862288,-1.7866757e-33,0.058013164,-0.02871118,-0.024180131,-0.01089494,-0.020658797,-0.009030482,0.022115447,-0.12507121,0.030927124,0.008640396,0.0447267,-0.039900076,0.03693223,-0.063908994,0.012050237,0.055502865,-0.008558896,0.037225936,0.027353248,-0.022363579,-0.040484942,0.12734713,0.06474284,0.053971026,-0.014137292,0.028516084,-0.004167697,-0.036276978,0.08104388,0.016945621,-0.03581315,0.0045469594,-0.10577475,-0.08038292,0.022408925,0.037843116,0.006150938,-0.009635476,0.061230794,-0.04972741,0.03357592,0.030212019,0.082857855,0.08097648,-0.036204744,-0.0021628265,-0.0033824767,0.047672305,-0.043731067,-0.05233028,-0.014757183,0.01912849,-0.03681423,0.04958831,0.019127049,0.040120542,0.033819653,-0.010863717,0.013909533,-0.05754039,-0.04130917,-0.06801979,-0.036787238,0.009777618,-0.00769538,0.07210704,-0.008532708,0.06318509,-0.036066845,0.01993573,0.021392064,0.017419994,0.032050513,-0.0068244818,-0.077682726,-0.019676447,-0.01823754,0.0054459153,0.022027625,-0.091036946,-0.039559316,0.00829023,0.0008906404,-0.019077778,0.12293439,-0.109342724,0.081410676,0.03527778,-0.033758633,0.0398561,-0.025015635,-0.06619027,0.056407142,0.13895753,0.0722629,-2.1523961e-08,0.0841835,0.012847031,0.0008002568,-0.06616801,0.025118593,0.0010874432,0.011296818,0.052289683,0.024901493,0.076079145,-0.05065638,0.04958022,0.034808334,0.017909711,0.13753097,0.07764471,-0.07316847,0.0058543202,-0.08292144,-0.060030967,-0.025634274,-0.031050602,-0.051381186,0.07634936,-0.032193627,0.06315883,0.09100252,0.00558198,-0.00046425706,-0.051805034,-0.018096026,-0.014792121,-0.05954484,-0.052840576,0.05218926,0.07661508,0.027588451,-0.012850804,-0.0049481723,-0.014236278,-0.13296345,-0.026848545,-0.12064487,0.084227525,-0.047132444,-0.014830659,-0.022313382,0.048770495,-0.01865846,0.025870118,0.015767481,-0.036871202,-0.0041620936,-0.042195514,-0.054217175,0.002639094,-0.003918187,0.045924254,0.109701954,-0.0014824554,-0.009652153,-0.021399783,0.09919565,-0.09380287 +2.7.4.11,AMP can also act as acceptor.,384,1.0,-0.06981542,0.00079666835,-0.04017669,-0.009819613,-0.07360441,-0.013776641,0.0566565,-0.05070262,0.0009288059,0.015405779,0.0898148,0.02264903,0.04871108,0.032994315,0.037195507,0.06541268,0.034328774,0.024634046,-0.0026803692,0.032407638,0.02522885,0.04334853,-0.022996442,-0.05473731,0.008475043,-0.05361866,-0.06275371,0.055208914,-0.005708105,-0.13529132,-0.030113025,-0.033301003,0.05416949,0.018004153,-0.13450779,0.06179033,-0.032997567,0.0040111323,-0.012117333,0.032232735,0.0062495708,-0.021991897,0.037700947,-0.05815416,-0.065643735,-0.07332831,0.02680032,-0.055098608,-0.04974575,-0.06888807,0.046676453,0.013272057,0.04068041,0.059062175,-0.06632556,0.021311428,-0.061407596,0.06523388,0.009388981,0.017545836,-0.03529472,-0.0032926498,-0.03798776,0.0051997723,0.022432212,-0.035482083,0.022948436,-0.02528634,-0.064965606,-0.04626716,-0.005945203,-0.040310655,0.037808787,-0.063636415,0.11427035,0.051460534,0.012395284,0.045858156,0.09975375,0.07503428,-0.065459855,-0.009183967,-0.09719175,-0.08674541,0.055427734,0.021660922,-0.06058533,-0.049298882,-0.08614809,-0.021530705,-0.011990737,-0.016852837,0.072236896,0.009073402,0.09043379,-0.06005042,-0.017654859,0.021675562,0.007804903,0.013177272,0.03698365,0.059002716,-0.09079843,0.0002554948,-0.026838941,-0.08258949,-0.0058472515,0.07852656,-0.025895042,-0.058868293,-0.01009779,-0.06270135,0.08060012,-0.0035340623,0.030087473,0.09678328,-0.03974245,0.013751537,0.045303706,-0.08793615,-0.07585452,-0.05723191,-0.032044895,0.031461693,0.0046599573,0.04834429,-0.024226924,-1.5123194e-33,-0.00949654,0.016367879,0.0014726829,-0.08005509,0.05262448,0.023502069,-0.07888217,0.06324581,0.017511385,-0.05972066,-0.0024439732,0.09082569,0.0802443,0.031156583,-0.027926162,-0.0023943114,-0.037318416,0.071026295,0.06995258,-0.07750559,0.01176894,0.05396707,-0.05431238,0.047845688,-0.021309052,-0.022748968,0.051313095,0.049228307,0.0030159003,-0.010996896,0.033475168,0.03435357,0.03722607,0.039104447,-0.024622278,0.029164162,0.027983962,0.03591088,-0.015298337,-0.08504473,-0.025670847,0.005307795,-0.124528795,0.068060756,-0.036400344,-0.023015799,0.025487488,-0.07230053,0.02730621,0.090278536,-0.044192314,0.005977524,-0.022746399,0.012771706,0.049406007,0.01782427,0.007234962,0.06855931,0.0011632806,0.061523955,-0.0552467,0.117321596,0.0004420037,-0.011579121,-0.16499512,0.022103071,0.06298232,-0.1250884,0.024802558,0.006534948,-0.01463604,0.031846892,-0.051260263,0.029836651,-0.052226156,-0.031836048,-0.050076615,-0.0051245387,0.06291825,0.0015244749,-0.0960649,-0.026047543,-0.04030464,0.05543142,-0.032420643,-0.031908337,0.06997219,-0.105071194,0.023916168,-0.022229044,-0.037091188,0.08250172,-0.08354521,0.037017763,0.100722805,-1.6071307e-34,0.08619526,-0.012240994,-0.011814073,0.0532112,0.05496247,0.03633709,0.10936,-0.064610936,0.088914745,-0.0031069242,0.04396704,0.029544445,0.051838458,0.047612272,0.037884463,-0.082691476,-0.0814987,-0.0036142536,-0.016970718,0.09038638,0.0015472798,0.058871556,0.052523777,0.030514518,-0.008496754,0.017054683,-0.10468272,0.0057939454,-0.011859675,0.02043046,-0.014801468,0.010275709,-0.053349208,-0.028318603,-0.054458093,-0.031654127,-0.0086281095,0.064401776,-0.055216853,-0.020837223,-0.006498276,-0.003401898,0.044644505,0.11521357,-0.0571709,-0.052762993,0.14859349,-0.008171924,-0.054008342,-0.05149108,-0.027585635,-0.023351492,0.051630206,-0.0048576323,0.035715137,0.0658073,0.060310997,0.010060317,-0.07100072,0.04870786,0.044441838,-0.042822037,0.045063008,-0.024372322,0.0049259956,-0.0544323,0.00957532,0.00024103728,0.09927341,-0.006480885,0.11993585,-0.087391,0.023534566,0.019757383,-0.031616878,-0.074213065,-0.07309554,-0.048134726,-0.010547991,-0.022157714,-0.106002666,0.09362282,0.021649327,-0.034201212,0.040362317,-0.008664674,0.042244095,-0.029244684,0.00048739294,0.056453086,-0.013172525,0.020507747,-0.0055735195,0.008957665,-0.05592794,-1.7877683e-08,-0.02750562,-9.275882e-05,0.018055962,-0.014159512,-0.030797215,-0.018688634,0.06772059,-0.078439064,-0.030018166,0.04593452,0.07267513,-0.024797799,-0.020781618,-0.015063209,0.07529454,-0.034213547,0.011234559,0.033807013,-0.05114404,0.08687745,-0.10092804,0.019491645,-0.0042153676,0.007929277,0.042779207,0.010885216,0.008092847,0.042122807,-0.03122182,0.054353043,-0.01606738,0.001894728,-0.016848339,-0.031426862,0.008690009,0.048953746,0.02860971,-0.05198839,-0.058094032,0.016355187,0.006188791,-0.07146487,-0.03967207,0.05119655,-0.05612548,0.07557398,-0.013397068,-0.04425311,-0.055989217,0.025811413,0.057000145,-0.042323902,0.00102059,-0.0117692305,0.0020061862,0.011306724,-0.047768794,0.0051360284,0.0064330087,0.032324582,0.05445673,0.037349455,0.097733274,-0.026378237 +2.7.4.12,dTMP and dAMP can act as acceptors; dATP can act as donor.,384,0.99999994,-0.1633171,-0.0021897804,0.009847976,-0.00965046,0.032619823,-0.06483647,0.046709295,0.02881057,0.010892616,0.037326593,0.045802094,-0.002506771,-0.013303606,0.01993216,-0.019611591,0.02621324,0.036524724,0.007987945,0.07585083,0.057538133,-0.041851357,-0.005371078,-0.06767716,-0.07030808,-0.004523283,0.040136576,-0.020357896,0.055622518,0.067961685,-0.02709974,-0.06460046,-0.0160063,-0.12731802,-0.030222053,-0.021959877,0.08755711,-0.027683767,0.032345433,-0.06932615,-0.035231374,0.03600137,-0.035250302,-0.005915738,0.0029159612,-0.0128620155,-0.0039384444,0.052605674,0.028611483,-0.07485038,-0.070895374,0.0554763,0.092861004,0.05098785,0.12528454,-0.07584098,0.025910024,0.03599437,0.017732415,-0.13181216,-0.012825296,-0.069462284,0.061269727,-0.04062274,-0.016034316,0.1613839,0.028277893,-0.03512649,0.054797743,0.052422963,0.012886931,-0.033836957,-0.03148944,0.0011992427,0.018097583,0.04136514,0.028489819,-0.018599922,0.015728835,0.12290365,0.0047086226,-0.001767153,0.02482512,-0.042176142,-0.03832583,-0.035534643,0.013859893,-0.040332455,-0.013971331,-0.0037242041,0.007348944,0.06620445,0.046330586,-0.055601683,0.04583949,-0.056303497,-0.035250247,0.046611737,0.041611888,0.046439484,-0.010185314,-0.0761119,0.048636544,-0.08738351,0.040997952,-0.026974306,-0.060649548,0.016457027,-0.08827899,-0.0011379422,-0.016946128,-0.07656882,0.027157638,0.022612803,0.059920784,-0.0093431305,-0.035886884,-0.10126335,0.016329994,-0.027638579,-0.14867538,-0.050654463,-0.05845451,-0.011824377,0.028010407,0.026628794,-0.037745584,0.008390548,-4.6481627e-34,0.030330457,-0.012785245,-0.013889787,-0.020761544,-0.027539747,0.020446926,-0.02888162,0.0012845987,0.0070034373,0.021050178,-0.07228932,-0.06309206,0.0032067776,0.07131321,-0.0463911,-0.03794115,-0.05550284,0.07640961,0.04548712,-0.058351114,0.035434976,0.1426933,-0.034726568,-0.010455903,0.027803928,0.021451073,-0.069037795,0.029256197,0.021707907,0.037005734,-0.006612856,-0.0420298,-0.009957851,0.046539508,-0.03453661,0.034698028,-0.043774873,-0.01144902,-0.02742288,-0.04559985,0.011130662,-0.03000261,-0.042504758,0.051892657,-0.007392103,-0.043292683,0.02895057,-0.103258036,-0.09052377,-0.009047049,0.037865043,-0.03394803,-0.07516002,-0.09364102,0.04500827,-0.0513327,0.00094564667,-0.014618428,-0.011312855,0.08087328,-0.029521372,-0.012462867,0.016466439,-0.11531857,0.0007518125,0.040917158,-0.024908358,-0.102915265,0.061298944,0.03969201,-0.008870417,0.064242445,0.00052278634,0.029234221,-0.0036798713,-0.034919187,0.034554232,0.05032819,0.04831043,0.03171377,-0.13155553,-0.057409335,-0.044506468,0.07202161,0.0017328574,-0.045147747,-0.007925085,-0.060855843,-0.03884635,-0.09062632,0.059280686,0.05338553,0.03765844,-0.029291304,-0.007106243,-1.3181001e-33,0.037485152,-0.013293866,-0.033627562,0.04359176,0.008430303,0.0057122526,-0.0091949785,-0.016215911,0.13547166,0.03621155,0.044077426,-0.07036435,-0.035940148,-0.0278475,0.07171514,0.02027337,-0.02999802,0.0127903065,-0.09399858,0.04731634,0.021862645,0.09675224,0.07421123,0.012319606,-0.003125391,0.0007092229,-0.031866573,0.042744324,0.026322383,0.034762222,-0.02764315,0.014347977,-0.07053491,0.054398723,0.032693986,0.048593286,0.01700575,0.013748818,-0.0852565,-0.044131577,0.06879126,0.038262047,-0.014784595,0.05400577,-0.008496783,0.042331647,0.004865688,-0.005439061,0.039628457,-0.009592122,0.10066362,-0.032895178,0.07051475,0.04477553,0.040815607,0.07220632,0.097153164,-0.033251535,0.012590268,0.018795686,0.032405946,-0.059605338,-0.0017824549,0.00053520536,-0.030745434,0.014112853,0.07125274,-0.007076569,0.029183567,-0.0047900476,0.08725796,-0.010470387,0.04274765,-0.007483649,0.051291868,-0.04737863,-0.038741674,-0.034613825,-0.008898851,-0.065159634,-0.1345797,0.073809445,0.044129677,-0.037667133,0.050320894,-0.01969722,-0.07801576,-0.05547193,0.05030323,0.082166195,0.00087302877,0.006366034,0.016927535,0.075835384,0.010220467,-2.105352e-08,0.0140059665,-0.022946566,0.04240403,-0.03144907,-0.022733944,0.00885337,-0.039731774,-0.010754494,0.07562993,0.010309764,0.047650218,0.0864761,0.022913208,-0.07204705,0.052127585,-0.04578263,-0.041338872,-0.06418722,-0.105399966,-0.10250796,-0.051771473,-0.0044204616,-0.022947425,0.070095286,0.09448818,0.0773922,-0.015322954,0.0041354937,0.05735674,-0.03828316,0.012556636,0.039944727,0.008728781,0.06810157,0.06368385,0.06357855,0.058775656,-0.049609806,-0.08703559,0.10563518,-0.021205325,-0.023618227,-0.070519,0.008252214,0.008367377,0.059304394,-0.031351402,-0.011134455,-0.069525994,0.012624655,0.021303454,-0.02117801,-0.024599167,-0.030295305,-0.053914346,-0.013927626,-0.06685853,-0.0040333336,0.04458212,-0.015247615,-0.0083747,0.106557734,0.07362287,-0.049104836 +2.7.4.13,dATP can substitute for ATP.,384,1.0,-0.09619825,0.050244983,0.014596541,-0.057185393,-0.00097551156,-0.0521547,0.03194393,0.048748143,0.010139861,0.018007616,-0.0032416699,0.026582256,-0.033322304,0.060139667,0.023633167,-0.04991228,0.035545897,0.07460741,0.09383815,-0.019509602,-0.02476606,0.037639,0.015204244,-0.011738099,0.03911791,0.07185673,0.023528576,0.050243627,-0.041383788,0.014487229,-0.062412966,0.016267752,-0.09949051,-0.0653214,-0.015175199,0.095133364,-0.0679987,0.015962822,0.020313429,-0.052349154,0.07348546,-0.0038616243,-0.037962575,0.06617553,-0.05539588,-0.003414443,-0.0045937733,0.031532325,0.009919221,-0.03878228,-0.016504774,0.017802278,0.011257273,0.04549529,0.020169485,-0.019759802,-0.066093855,0.0468087,-0.062929735,-0.0066823363,-0.0887117,-0.012394094,-0.012661189,0.024058368,0.08654588,-0.03876801,-0.026940048,0.08255695,0.02586833,0.04313313,-0.09229446,0.0015712677,-0.0009993148,0.07802382,-0.029627446,0.04972441,0.0123264,-0.06767635,0.12396674,0.0037605609,-0.01693156,0.06853781,0.012003128,0.021353882,0.09942026,-0.010026079,0.0035170603,0.0051106145,-0.04519868,-0.0012356882,0.06304224,0.032734167,0.007072909,0.007809253,-0.068036616,0.057954144,0.0057322676,0.008140621,-0.024564363,-0.02032632,0.04436095,0.109379694,-0.024979979,-0.02876463,-0.01195665,0.03535843,-0.005183256,-0.034573372,-0.011317424,0.006927446,-0.015567354,0.018278029,-0.033714473,-0.04071692,0.02028019,0.039136067,-0.0870537,-0.028971948,-0.074981034,-0.03430365,-0.08147777,-0.13393943,-0.024831181,0.043341767,-0.04999535,-0.005807566,0.024627032,-2.6460404e-33,0.0017610793,-0.029198773,0.052942228,-0.007464844,0.034560688,-0.020921603,-0.07349139,0.0022620317,-0.008961773,-0.07963828,-0.033848908,-0.12003299,-0.0040208404,0.00022853608,-0.018520622,-0.04882562,-0.11054509,0.12148071,0.100464605,-0.06275914,-0.0026614286,0.07036178,0.027348284,-0.0582325,0.04226344,0.038478933,-0.06529677,-0.031592526,0.050611407,0.009172541,-0.016579552,-0.049300965,-0.08381474,0.0046542827,-0.08416557,-0.019161487,-0.042129107,-0.08127835,0.046454396,0.02305398,-0.010055258,0.036502473,0.015104329,0.02779485,0.016568843,-0.04134852,-0.010547383,0.007390319,-0.04620775,0.0017781936,0.105207965,-0.04430278,0.022497116,-0.07921876,0.008639653,-0.01937727,-0.010862401,0.007981613,0.043993715,0.123668656,0.012072431,0.03133821,-0.026486846,0.018304855,-0.012219424,0.07702779,-0.08385837,-0.10931707,0.0245545,0.10555402,0.015313176,-0.044087466,0.06799039,0.008018753,0.030092742,0.031665154,0.052227497,0.06132096,-0.031132266,0.0663681,-0.027812338,-0.07316653,-0.055956047,0.04830436,-0.013271662,-0.013727838,0.005864739,-0.03561877,0.07562476,-0.017731313,0.14140068,-0.0251204,-0.06250157,-0.008433245,-0.0692019,1.9128327e-33,0.05862467,-0.0071931873,0.08253962,-0.007300104,-0.006925443,-0.014281636,0.08335304,-0.09021045,0.061548166,-0.011505029,0.017364372,-0.072189815,-0.067951225,-0.051818535,0.015651206,0.0145773105,-0.025719099,0.061205048,-0.07899717,0.06658814,0.028623162,0.077364385,0.09498263,0.042429667,0.037640225,0.013156288,-0.014988109,0.012259418,0.061787777,0.011061799,0.020690273,0.017061511,-0.13075106,-0.01392478,0.04993222,0.026708532,0.017692205,0.018084703,-0.03630094,-0.004207116,0.061613698,0.06583912,-0.023830365,0.06511513,-0.013636681,0.01812965,-0.00052864966,0.06470994,0.009795728,-0.01735898,0.013615645,-0.015616829,-0.05940891,-0.03312873,0.05821458,-0.00409452,0.01277739,-0.018443557,-0.008914397,-0.057699084,-0.055375688,-0.05236941,0.012222974,-0.037869267,0.049568556,0.07957507,-0.018897712,-0.023447754,-0.0332752,0.033182304,0.068336606,0.036607582,0.032120507,-0.034462716,0.023169156,0.05922295,0.016697902,-0.0062723206,0.004718645,0.03569907,-0.08579263,0.08120786,-0.07934071,-0.10066276,0.017340146,0.03415785,-0.056144208,0.0404503,0.008835616,0.040107775,-0.0060235485,-0.031420495,-0.006754814,0.0916412,0.0614542,-1.2985942e-08,0.005419795,-0.024498034,0.10673001,-0.03413833,0.010988154,-0.00022928369,-0.02000362,0.0057507255,0.12394411,0.037205774,0.054351643,0.10338053,0.1142128,-0.03330349,0.032540385,-0.004299053,-0.010328692,-0.028974175,-0.05396484,-0.08733361,-0.09026349,0.018960679,-0.046991732,0.087359466,0.06535477,0.004293583,-0.035610035,0.024909073,0.050140575,-0.13721469,0.03928899,-0.026932245,0.052239425,0.028890882,0.06794108,-0.011497157,0.0023251185,0.024561979,-0.09827424,0.038368925,-0.12172704,-0.06943603,-0.016708162,0.026663275,-0.022868626,0.008541948,-0.023855435,0.04594324,-0.07294892,-0.06257293,0.019148864,-0.02848627,-0.008148961,-0.109857306,-0.020166963,-0.0038436472,-0.049922112,-0.0353153,-0.03918574,-0.043445926,0.0030583555,0.029016478,0.120421715,-0.011971864 +2.7.4.14,"This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, (d)CMP kinase and EC 2.7.4.22, UMP kinase.",384,1.0,-0.102402315,-0.008714466,-0.10146985,-0.0027771643,0.06894978,0.005804885,-0.026110757,0.055455912,-0.004881924,0.03942161,0.027604641,-0.07518306,-0.07598651,0.030042052,-0.011958447,0.076428175,-0.043902,0.04251969,0.018335469,0.00041216152,-0.012132954,-0.01944207,-0.07907903,-0.030693254,-0.005517327,0.0118339155,0.06956606,0.013129094,-0.031130841,-0.080346584,-0.011158697,-0.07345337,0.084843695,0.033821758,0.02586944,0.085035704,-0.08174281,-0.108353235,-0.019967334,-0.046425544,0.09161484,0.03961338,0.05982997,-0.0050402195,0.015038613,0.05792624,0.032832827,0.026677165,-0.008283446,-0.030673843,0.012839053,0.019842992,-0.0359353,0.033255443,-0.11826064,0.039096903,-0.0999564,-0.011821833,0.02602059,-0.014819848,-0.038311083,0.0071406015,-0.0078035714,0.04481917,0.12963234,-0.12178964,0.012702964,-0.027070424,0.057094395,-0.0019781773,-0.03545204,-0.10508267,0.01272101,0.046038315,0.016095024,0.05809281,0.011663541,0.006852924,0.15425359,-0.028206764,0.014852372,0.055717252,-0.007040492,-0.032165386,0.014148819,-0.02526461,-0.023821317,0.020281903,0.054997876,-0.046245955,0.01389736,0.0072558685,-0.046741445,-0.010169479,-0.08182274,-0.0051007713,0.06866689,0.099035494,-0.023713306,-0.008507846,0.01666641,0.121718526,0.008060635,-0.07479368,0.011320976,-0.064488865,0.05352524,0.068693526,0.009872604,-0.008305289,-0.030846434,0.005272616,0.033610992,-0.025672555,0.098658256,0.05960936,0.00025528838,-0.07267102,0.002025344,-0.0035832373,-0.076120116,-0.07034726,-0.038074043,0.029996715,-0.06595606,0.05029087,-0.047280103,6.4327964e-34,-0.011771547,-0.030152561,0.0010702187,-0.09223752,-0.011695814,-0.013642712,-0.01779812,-0.02992766,-0.058924608,-0.07718849,-0.043081068,-0.024626147,0.034679893,0.083627485,-0.068334304,-0.0745713,-0.00604154,0.036937688,0.098576866,-0.025850361,0.040538263,0.09266605,-0.04082268,0.008652826,0.067829005,0.027555507,-0.05430711,0.031071948,0.0115021365,0.025197122,-0.001608091,0.0100981025,-0.101611614,0.056803,-0.04748777,-0.0031558606,-0.049172617,-0.04345474,0.00748737,-0.03146493,-0.05806726,-0.022173962,-0.052635387,-0.0014740839,-0.02124999,-0.038376752,-0.11722931,0.02537344,0.030912852,-0.023367662,0.056171246,-0.052053846,0.0552077,-0.03754969,0.01159733,-0.038280934,-0.07637896,0.013005118,0.03607627,0.036689304,0.0092067635,0.0615061,-0.12244938,0.055842284,0.014990076,-0.010773879,-0.069880754,-0.048189003,0.10011647,0.088556856,-0.036719617,0.032912526,0.09752582,0.0022165575,-0.008190949,-0.0107629355,-0.010541227,0.020705892,-0.043892864,0.12041216,-0.069649644,-0.03721954,-0.019109696,-0.0240741,0.0072369967,-0.08944799,-0.01951965,-0.03861467,-0.043258347,0.0027725666,0.06598549,0.023082532,0.02177691,0.12762925,0.0019555525,-3.3279472e-33,0.062140957,-0.05562618,0.04018092,0.0002436787,-0.060575772,0.09228384,-0.01922852,-0.065457754,0.044614527,-0.035582397,-0.0012175046,-0.05928197,0.06591162,-0.0061361175,0.10498607,-0.012349638,-0.049146704,0.11568957,-0.0013882486,0.08674403,-0.0029993686,0.086683795,-0.011751623,0.029714074,0.0092571685,-0.011987657,-0.04957044,0.007076807,0.0038408593,0.033599187,-0.015370481,0.10337515,-0.05985815,-0.032292377,-0.004318753,-0.028382795,-0.02229871,0.06056665,-0.003541925,0.000511916,0.05737277,0.04332489,-0.061501663,0.05480753,0.030660566,0.10044782,0.04968216,0.007890693,-0.027385993,-0.016262697,-0.015260209,-0.037536353,-0.027223956,0.029865088,-0.017565956,0.09767249,-0.0075272624,0.022418115,0.017227372,-0.029191038,-0.06309122,-0.098137796,0.029443804,-0.02200393,0.037919007,0.06564717,0.0066618803,0.020282265,-0.031417068,0.018117018,0.07214156,0.06520822,0.017045492,0.02071311,-0.0019128411,0.020324936,-0.032244645,-0.039359394,0.0007159208,-0.06283356,-0.031248117,0.03229862,0.0499674,-0.021709023,-0.060707908,0.0089258095,-0.030444201,0.013949093,-0.022430789,0.035079528,-0.02688388,-0.07268811,-0.04455535,0.057553116,0.037555046,-3.7614882e-08,0.05372057,-0.032551613,0.019451112,-0.07500442,-0.020393237,0.10498211,-0.052004643,-0.00446439,0.07007883,0.050517496,0.048978485,0.07117762,0.0036473935,-0.07835789,0.022126151,-0.0011128461,-0.01710668,0.03921115,0.011239168,-0.0019565818,-0.021574011,-0.03681072,0.010723011,0.10578301,-0.0053198687,-0.023793645,-0.005929134,0.082930654,-0.03423036,-0.020585185,-0.027489128,0.033531003,0.00884408,0.023918577,-0.026214639,0.0012879133,0.05520848,-0.12555109,-0.04801008,0.0464159,0.042540364,-0.07347885,-0.044036843,-0.020287493,-0.034117285,0.035575274,0.08494271,-0.03641817,-0.05915543,-0.044125807,-0.042037643,-0.028763281,-0.053318385,-0.07081178,-0.07018982,-0.011926528,-0.06849225,-0.05162136,-0.04511137,-0.018730287,0.021260453,0.0400287,0.13136634,-0.06281544 +2.7.4.18,ADP can also act as donor.,384,1.0,-0.10873956,0.003379462,-0.016804812,0.00079889514,0.012063715,-0.030600386,0.08494418,0.035648633,-0.03691296,0.016929677,0.07661674,0.02988179,-0.10666513,0.054342687,0.026473375,0.05341901,0.040190037,0.022714775,0.035065617,0.10082329,0.0061697117,-0.019797256,-0.013224318,-0.07323139,0.04333968,-0.034743976,-0.045917027,0.0069419905,-0.0004873372,-0.0032095641,-0.016501656,-0.02621806,-0.021518944,-0.03852009,-0.0070725516,0.06803459,-0.02911871,0.07657486,-0.045399528,0.00074821466,0.08604832,-0.0006376078,-0.01807579,-0.020183241,0.00016271776,-0.054580927,-0.024626069,0.015495202,-0.0149846235,-0.013085826,0.009598932,0.042744327,0.026465286,0.03259135,-0.12828651,0.05197024,0.020874416,-0.036488663,-0.05543976,-0.030269325,-0.04895172,0.05929798,-0.014545676,0.0013718132,0.09967416,0.041098636,0.08883341,-0.044693228,0.020169027,-0.01192062,0.0419772,-0.00035033093,-0.0067399326,0.041498125,0.04648067,0.04797296,-0.039718155,0.020340128,0.09830466,0.02522019,0.022872956,0.03113083,-0.050504774,0.01787256,0.03200473,-0.0036790539,-0.07133724,-0.045916695,-0.06209009,0.022818202,-0.08250065,-0.0077891555,0.027671896,-0.0026761848,-0.06527256,-0.015075352,-0.01980729,0.016708208,-0.032728788,-0.011353594,-0.093477264,0.07076206,-0.002225485,-0.03565765,-0.018290592,-0.09036785,-0.03568069,-0.051451325,0.08237833,0.038908686,-0.012746714,0.0073280046,0.076647356,0.0058131283,0.05180626,0.09147429,-0.17538439,-0.06882137,0.016685618,-0.04515883,-0.005502921,-0.03166023,-0.03699213,0.015924707,0.066530965,-0.005513014,-0.01612769,-2.2361949e-33,0.020271117,0.0031844014,0.11267646,0.057033323,0.0129749775,0.056919675,-0.042202365,-0.06935098,0.017486893,-0.053978752,-0.06705515,-0.064901136,0.08618115,0.097095564,-0.10950929,-0.0076140473,-0.06582709,-0.006718159,0.054451596,0.03391993,0.016565973,0.10232318,-0.046310242,0.028376844,0.045612965,-0.032313753,-0.066066615,0.040666133,0.032154568,0.017797764,-0.0067536957,-0.015554663,-0.06360106,-0.0016509362,-0.0358625,0.041126512,-0.019714471,-0.10713887,-0.018847173,-0.026013134,0.03709047,0.0053307856,0.07750869,0.059057392,0.0392674,0.01655834,-0.03586396,-0.08536937,-0.08918777,0.045908563,0.027760403,-0.031576928,0.01419088,-0.09080838,-0.027478002,-0.022911442,-0.03212344,0.014979397,-0.0068603884,0.07199276,0.025847109,0.04148276,-0.014248516,0.054394964,-0.15263909,0.044818047,0.07768958,-0.14140187,-0.009640802,-0.0018272887,-0.04337977,0.007420208,0.0151275825,0.03199151,-0.07975406,0.009415884,0.06451276,0.037430815,0.06681771,0.025311053,-0.12443474,-0.09232443,0.056530505,0.07040545,0.064323545,-0.050374713,-0.024647629,-0.058867548,0.042705406,-0.06318137,0.016860738,0.028830146,-0.0961077,-0.008236489,0.017700097,-4.813421e-34,-0.03554177,-0.07504228,0.040480237,-0.0118490625,-0.0059705963,0.021329215,0.06195655,-0.016960861,0.11211571,0.03498496,0.014686646,-0.022455405,0.05657639,0.01385354,0.02805734,-0.00051397225,-0.077981815,-0.0046434267,-0.031302676,0.03507129,0.01915715,0.15103924,0.079516,0.045425385,0.030108867,-0.013083489,-0.07353617,0.028470354,0.09401529,-0.049723893,0.045415536,0.040548872,-0.13699472,-0.027218489,-0.031636447,0.028071634,0.028174542,-0.020271221,-0.05704791,-0.042176496,-0.0010663734,-0.047434237,0.02186031,0.06579161,0.003968002,0.021472724,0.09923916,-0.020993477,0.022592796,0.023230115,-0.0277127,-0.0127939675,-0.0018458619,0.04072942,-0.017172372,0.04888554,0.06774491,-0.05472094,-0.020073298,-0.050683677,0.028840937,0.04223146,0.041617684,0.039810244,-0.04344087,0.025155472,0.11014523,0.0025148392,-0.032089762,-0.019220235,0.0705081,-0.01399122,-0.03769004,0.02591782,-0.01749297,-0.02424116,-0.11179073,0.010519408,0.0280197,-0.08949143,-0.069840066,-0.04971818,0.027111162,0.06184405,0.01795587,-0.019599572,0.02362262,-0.038496766,-0.0046531255,0.023319708,-0.08308564,-0.030860497,-0.043320876,0.01318368,-0.04303744,-1.6603167e-08,0.047449727,0.1282957,0.05512991,-0.051381145,-0.047448315,-0.049190227,-0.03948338,0.0064643216,0.0126732215,0.047791865,-0.004094006,0.12092466,-0.010993166,0.008063409,0.04027209,-0.030438548,0.006799265,-0.038411256,-0.06837014,-0.07091827,-0.069150075,-0.015241957,-0.00982539,0.09451856,0.0047085197,0.004834401,0.04912686,0.02819787,0.06583078,-0.041378904,0.0057972926,-0.016593857,-0.083462484,0.04880669,0.023064451,0.02620761,0.05106517,-0.117513515,-0.0206251,0.026595173,-0.057923056,-0.062319905,0.01327419,0.03492111,0.011222427,0.042320844,0.009501795,-0.06392981,0.0118179945,-0.005264359,0.030471552,-0.030266574,-0.012957693,-0.053045835,-0.037552815,0.005519032,-0.03557295,0.011419152,0.07516496,0.02378802,0.014105867,0.0330474,0.08630777,-0.017094895 +2.7.4.19,"The enzyme, from phage XP-12-infected Xanthomonas oryzae, converts m5dCMP into m5dCDP and then into m5dCTP.",384,0.99999994,-0.024539562,-0.011331241,-0.034371905,-0.05697678,0.07721632,-0.010351098,-0.03956267,0.030074181,-0.05683323,0.0030764714,0.08520765,-0.024442948,0.05097162,0.030695269,-0.05304069,0.10720154,0.008385433,0.042527795,-0.0050697126,0.07175731,0.07039621,0.020065483,-0.012132416,-0.05019745,0.016365753,0.014275482,0.048935346,0.0077467724,0.05373303,-0.07678186,0.009186396,0.06778736,-0.059464764,-0.06683555,0.056375977,0.016046572,-0.006805253,-0.050384287,-0.0071897786,-0.00898684,0.06596837,-0.023091236,0.0038827336,-0.020769462,-0.019937972,-0.030471308,-0.088384144,0.038716115,0.0056914142,-0.030738369,0.059092842,-0.0069059404,-0.09472503,0.019441575,-0.0026325523,-0.03105112,-0.024786988,-0.0005700734,-0.04687125,0.0099728955,0.011902767,0.10698143,0.021392887,0.032789063,0.027288405,-0.02625247,-0.05969734,-0.008786804,0.023159275,-0.035443056,-0.091199,-0.086116835,0.021153396,0.013863721,0.034987196,0.039416336,0.027199678,-0.015269904,0.059914757,-0.025491415,-0.018640291,0.08602753,0.014775869,0.0127166025,0.053903032,0.008091872,-0.016442781,0.10238906,0.0043125376,-0.05629321,0.027599394,-0.009535763,-0.10920744,0.024966214,-0.111365676,0.014632007,-0.005419431,-0.040927324,0.022077104,-0.005534314,-0.025898831,0.022771707,-0.050115753,-0.10960521,-0.067942366,-0.07634559,0.054683477,0.070359305,-0.015574186,-0.06159964,-0.04548006,-0.07645341,0.029059744,-0.017349916,0.07783153,0.08640157,-0.027802242,-0.00032397287,-0.035790384,-0.06859012,-0.0234232,-0.09013032,-0.07766546,0.04244678,-0.016380144,0.045473345,-0.0544526,3.612157e-33,0.012553161,0.06440922,0.019833136,0.022626111,0.026430093,0.01674692,0.04543558,0.018705262,0.027704062,-0.0046154065,-0.05703974,-0.06346134,-0.012713866,0.0067613935,-0.085006766,-0.08493968,-0.041518718,0.042118743,-0.006986238,0.03818743,0.045345765,0.08510362,-0.020417808,-0.01309244,0.049114335,0.16650276,-0.039346553,0.012847611,0.12325974,-0.027040254,-0.05030647,-0.02208846,-0.11051844,-0.018927192,-0.032220285,0.07758175,-0.023044843,-0.057095867,-0.027775697,-0.0010986838,-0.01808374,0.01834742,-0.010352482,0.011469556,0.032005206,0.0057835258,-0.15416694,0.0136657385,0.037005328,-0.036494445,0.050261095,-0.023431031,0.042494312,0.021347605,-0.05394364,-0.011743565,-0.052845955,0.037571274,0.0046627433,0.021366308,0.027364936,0.0016085707,-0.010761297,-0.030374087,0.037929785,0.009747663,0.04461837,-0.01785404,0.010369257,0.05512113,-0.055037905,0.011038937,0.08068707,0.009672525,0.037951514,-0.023499053,-0.011723355,0.0023788621,0.0123810945,0.027134161,-0.032309517,-0.0056233155,0.03543407,-0.076845415,-0.0358512,-0.036330383,-0.015633505,-0.006239489,0.006161835,0.03516518,0.10897834,-0.058037058,0.017769571,0.08015621,-0.08266697,-3.7805452e-33,-0.051116563,-0.033521913,0.059927568,0.002673226,-0.046317853,0.035249352,-0.004288581,-0.0019222779,-0.025452202,-0.02377073,0.05964303,-0.0004880346,0.047466695,-0.014820984,0.009995258,0.050693676,0.047370262,0.06362676,0.023159439,0.024562908,-0.042445958,0.09097708,-0.04731025,0.028334077,0.06964353,0.11115554,0.023208184,0.0013901608,0.07972718,0.019396147,0.0031872601,0.048108608,-0.09534502,-0.038931627,-0.014667743,0.030135376,-0.014348097,0.059763633,-0.061953537,0.027095202,-0.0043906895,0.018782672,-0.025128441,0.07316846,0.0010239794,0.05739717,-0.019157952,-0.034608085,0.113277085,0.0414861,0.033265654,-0.056353476,-0.04707304,0.009122288,-0.06519607,0.06745491,0.04346117,-0.0071756206,0.012181359,-0.019995209,0.004905048,-0.076320805,0.0006421173,-0.008720021,-0.05083459,0.11323336,0.0859653,0.053858496,-0.041117042,-0.05097136,0.006072273,0.029308893,0.02323552,0.022437116,-0.024150489,-0.045331538,-0.0394928,-0.06263901,-0.021431921,-0.07647201,-0.021532057,-0.058941003,-0.0009647615,-0.028481726,-0.010399238,-0.057195008,0.09654405,0.061593454,0.027660178,-0.039198656,-0.052919187,0.061030462,0.0046098502,-0.0058046915,0.04856527,-2.817098e-08,0.054962162,-0.117987186,0.018350115,-0.06885716,-0.0010016822,0.04042751,-0.12433708,-0.014472078,0.10893738,0.024074497,0.03388829,0.0015012054,-0.032456823,-0.007833099,0.044741295,0.025789984,0.0014193526,0.0096506495,-0.018813577,-0.08207869,-0.10634767,-0.0018051316,-0.0106078535,-0.0039420687,0.05084355,-0.061477683,0.053818084,0.101075575,0.07517305,-0.08650826,-0.071159236,0.04808617,-0.040312387,0.030238664,-0.026746456,0.149424,0.003036532,-0.03156572,0.020920122,0.018054068,-0.0013074743,-0.09409896,-0.044789154,-0.02394994,-0.00088980445,-0.058073357,0.050633468,-0.06530445,0.0054799854,-0.03871971,0.0025199745,-0.030879634,0.028488126,-0.16058575,-0.049764816,0.0064962027,-0.057538666,-0.0067283404,0.031338304,-0.043586973,-0.108209334,0.01386307,0.18476233,-0.027449513 +2.7.4.21,Three mammalian isoforms are known to exist.,384,1.0,-0.0702907,-0.117485255,-0.047465473,-0.036425482,-0.08805009,-0.000111311936,-0.035635035,-0.04387828,0.04313213,0.043111,0.07366989,-0.10921232,-0.060616393,0.07262061,0.07244168,0.00532704,-0.14901161,0.049324475,0.022036608,0.0040976293,0.04080452,0.001346635,0.036519207,0.006775147,0.020375207,-0.019550806,0.0017743248,0.021030266,0.024420217,-0.075103655,-0.05940097,-0.06419743,0.09412121,-0.046709843,0.050650407,-0.08712905,-0.078142166,0.03433905,0.02460943,0.016995773,0.039774243,-0.03170364,0.028950982,-0.010699196,-0.011682462,0.011325993,-0.0783739,-0.04560435,0.056118574,0.029622842,-0.00942684,-0.08273481,-0.06806198,0.1332574,-0.034899134,-0.07640642,-0.056923423,-0.023656,0.02741992,-0.0040129856,-0.024102377,0.018300004,0.030572606,-0.012421642,0.07097423,0.060044054,-0.03581406,-0.047357794,-0.051846776,0.017899198,0.04787761,-0.033811726,-0.056615844,0.05001388,-0.07185564,0.039825086,0.022163177,0.05912476,-0.019528724,-0.04023653,0.008485324,0.042421512,0.0038787327,0.077778384,-0.00697017,0.007176717,-0.10193308,-0.013996572,-0.14327323,0.0029060103,-0.014225975,0.036997374,0.010095855,-0.015515105,0.045423213,0.05424409,0.06358111,0.04770827,0.11529451,-0.021122968,-0.010094851,-0.048517395,-0.02818008,-0.030963974,0.08874771,-0.0024223367,-0.06227723,-0.047715757,0.042447228,-0.008032298,0.0093864435,-0.027198417,-0.011229788,0.021519959,0.09027214,0.022190714,0.019197347,-0.018495066,0.03877584,-0.004767733,-0.016006468,0.020792525,0.07696623,-0.017611057,0.021469515,-0.04658113,-0.03019025,-4.4190605e-33,0.058039933,0.023814468,-0.014017167,0.112314,-0.008721238,0.050604414,-0.034728102,-0.034921527,-0.04557124,-0.051088672,-0.107702434,-0.007558673,0.0027119638,0.033042032,-0.04353809,0.025375847,0.0006803258,0.04090753,0.03699069,-0.08995823,0.031689472,0.098564774,0.030772613,-0.08913038,0.0018768512,0.013297889,-0.09922286,-0.024777941,0.010704192,-0.027311726,0.00824717,-0.0430685,-0.082620144,0.051136423,-0.03926723,-0.024610749,0.011984276,-0.08707833,-0.013085425,0.08352993,0.1215279,-0.02354067,-0.021897111,-0.11151422,0.08228109,0.08105528,-0.044437367,0.004426821,-0.005255366,-0.019520506,-0.01050191,0.056873657,0.030449301,-0.015689546,-0.05731392,-0.013259705,-0.04632916,-0.076623194,-0.049703345,0.029053168,0.023997726,0.05832627,0.009679586,0.044004824,0.041066382,0.06573454,-0.13847813,-0.056733694,-0.0020745762,0.08231506,-0.0025777689,-0.08333465,-0.03577374,-0.10743239,0.036014315,-0.035054617,-0.039609194,0.04372803,-0.07315947,0.04565033,-0.07910792,0.043527212,-0.072175905,0.044695426,-0.017220626,0.015481854,0.0771327,-0.05646841,-0.006528886,0.010405942,0.05678782,0.017220281,-0.10207271,-0.027739462,0.020167254,1.2790122e-33,-0.05205575,-0.027082326,0.018621668,-0.08443125,-0.06964111,0.1056506,0.00041956763,0.03163217,-0.029762162,0.048849527,0.051375188,0.021666361,0.011700737,-0.13962916,0.03238841,-0.004517802,0.022995783,0.047802527,0.08126213,-0.048764136,-0.0019894938,-0.04279456,-0.118914045,0.08593063,0.0131704975,0.03654398,0.008278525,-0.025064602,0.012705049,0.009143845,-0.048437487,0.044536874,0.027369928,0.003112984,0.07128796,-0.012996972,-0.010526325,0.048126522,-0.03526338,-0.08628174,-0.022375878,0.051341683,-0.0052326056,0.05778451,0.032968193,0.03699592,0.07012357,0.05896848,-0.04199676,0.06198645,0.034339126,-0.092854775,-0.03594644,-0.06977151,0.024464987,0.009762924,-0.065279625,-0.04465683,0.08916348,-0.0016027065,-0.029178064,0.006711715,0.015799778,-0.0031244613,0.068035394,-0.023549035,-0.027200952,0.014208422,-0.046813525,-0.0009946417,0.07293497,-0.008378325,0.011521334,-0.06871886,0.049012862,0.04068308,-0.01865405,-0.019423546,-0.049244624,0.0053319633,-0.009380113,-0.020224022,0.046189677,0.052196093,0.0057735466,0.015930776,-0.009466791,0.10380655,0.06752124,0.037367895,0.0200172,0.0566637,-0.050281085,0.1017119,0.047120705,-1.8131333e-08,0.0675235,0.033150766,0.056165073,-0.09808509,-0.085687004,0.060664143,-0.0057608844,0.06342788,0.011018036,0.017765306,0.026129276,0.007572534,0.04669869,0.032355066,0.061548572,0.037879437,-0.03872493,0.045662276,0.0065979785,0.046570323,-0.07548618,0.006171821,-0.050041445,0.0033352273,-0.011759517,0.003714122,-0.007515735,0.03632361,-0.0050101564,-0.018850543,0.07602565,0.014060971,0.04572935,-0.02541878,-0.0057592303,-0.012423017,0.025627496,-0.048350863,0.0011005951,0.0155087225,-0.011526417,-0.024854628,-0.05614926,-0.011601751,0.07571145,-0.0085105235,-0.03309477,-0.001765615,-0.0148676075,-0.045075916,-0.10234772,0.033083886,0.008885936,0.0068587,-0.04770125,-0.037206437,-0.041424368,0.0058906847,0.058794465,0.011639368,0.0757288,-0.0031607195,0.11858455,0.04785853 +2.7.6.1,dATP can also act as donor.,384,0.99999994,-0.12153946,0.052023925,-0.012613098,-0.058915354,0.023404688,-0.02321778,0.079802476,0.052278385,-0.017537776,0.037784196,0.02653028,0.03540889,-0.033746168,0.07438862,0.024368146,-0.0034851274,0.024166552,0.0037660396,0.047497183,0.05327285,-0.07631906,-0.018664865,0.02786887,-0.06647186,0.063743226,0.022698754,-0.010393069,0.047595765,0.029671593,0.028105471,-0.015150518,0.029235413,-0.16721387,-0.0128440205,-0.018815638,0.09150266,-0.008008736,0.07263335,-0.045768213,-0.03176243,0.081160925,-0.04569239,-0.028962314,0.022323022,-0.047896203,-0.00477629,0.004571562,0.018137945,-0.023286663,-0.04891241,0.01708166,0.020951753,0.020927541,0.105758294,-0.037253674,0.015714375,-0.0057136356,-0.0063321674,-0.06881556,-0.022729045,-0.10806951,0.040754896,0.01576387,-0.01180736,0.11997322,0.003966006,0.00834313,0.028323004,0.008751612,-0.01653504,0.032112304,0.0035960542,0.0054345876,0.07298177,0.004231952,0.041321725,0.007884664,0.019272942,0.09013471,0.03978765,-0.053845808,0.09708256,0.0062264665,-0.0031057422,0.029111145,0.020745689,-0.07171744,-0.012454766,-0.09343013,0.04011187,0.0043089488,0.024447968,0.023951132,-0.016229268,-0.07924367,0.014338202,-0.0043992577,0.011280423,0.00021902163,-0.0083560115,-0.04363919,0.054758444,-0.0033490448,-0.03740598,-0.029883536,-0.014397778,-0.049615327,-0.107492164,0.0016130842,-0.023902252,-0.03515225,0.022943867,0.008178315,0.038337927,0.008033971,0.081777215,-0.17300852,-0.017077895,-0.07172062,-0.08017645,-0.035523046,-0.06992461,-0.008278624,0.014002907,-0.03009925,-0.05702298,-0.024435846,-1.7584242e-33,0.0008451294,0.003845503,0.07637164,0.0009057995,0.021529714,0.018408354,-0.036487367,-0.0012048524,-0.0127312895,-0.024996286,-0.046515618,-0.11954689,0.05124714,0.0289782,-0.09374743,-0.01191348,-0.13049425,0.0502278,0.013492659,-0.021455413,0.024137627,0.12197173,0.014943716,-0.012804832,0.049249437,0.0048745954,-0.07437424,-0.007334488,0.060214955,0.024137227,-0.015512718,-0.0009768341,-0.017682869,-0.018304337,-0.061805855,0.0068025165,0.013019313,-0.09001596,-0.035570625,0.024241839,0.06177211,-0.0025027234,0.0056982553,0.07766448,0.010854513,-0.01330991,0.02712277,-0.11359356,-0.10247491,0.014534559,0.019450335,-0.03855756,-0.007819937,-0.12136678,0.0031448985,-0.016289845,-0.011345145,-0.015785616,0.011059638,0.057728264,0.0013122306,-0.022557568,-0.004009194,0.004468962,-0.10995994,0.03265355,0.031462513,-0.13181435,0.0028529717,0.06365501,0.008142711,0.021602029,0.0065034474,-0.0069160047,-0.0023886613,0.008272919,0.048746742,0.07993338,0.07279678,0.043865494,-0.08567988,-0.05043552,-0.02459845,0.0674812,0.06638211,-0.026308632,-0.017854145,-0.1085221,0.019729886,-0.0809714,0.078637764,0.012989411,-0.031431288,-0.10185881,-0.046424538,2.3959337e-34,0.018268144,-0.03435266,0.034628965,0.025162997,0.06725036,-0.042805005,0.07571982,-0.03487263,0.11302358,0.051610492,0.02028737,-0.06365465,0.04734969,0.00017461623,0.06158685,-0.004397663,-0.029278621,0.04571988,-0.07352184,0.03321973,0.034114644,0.071909085,0.109386556,0.030533902,0.018396905,0.041661385,-0.084512256,-0.0053963107,0.09886012,-0.020898193,0.013378284,0.02803622,-0.18159792,-0.039360225,0.013028502,0.027532088,0.029922174,-0.00356633,-0.069931224,-0.06666503,0.049475435,-0.014316333,-0.014351649,0.121964805,-0.05523626,-0.022126347,0.056619268,0.07585721,0.0796591,0.017395703,-0.011996615,0.0027847227,0.016781028,0.018880675,0.0051756664,-0.006308396,0.07863761,-0.047192823,-0.015936378,-0.059443813,0.010865511,-0.016971188,-0.023581205,0.04662255,0.025678588,0.016349263,0.090358265,-0.020548847,0.0140096415,0.03210474,0.08040728,-0.0432543,0.0065470384,-0.0057278755,0.011144645,-0.0070053465,-0.052505996,-0.010486528,0.045860708,-0.028038213,-0.054161757,-0.041754488,0.022421796,-0.024190014,0.066783406,-0.00071015145,-0.0022512039,-0.017917305,0.01288462,0.021225134,-0.08624767,-0.018341593,-0.035311162,0.081903405,0.0069958405,-1.7243371e-08,0.008177596,0.03311265,0.027071897,-0.03197548,0.0035327733,-0.060430367,-0.056536462,0.0039575878,0.0766166,0.08753452,0.007815518,0.11422336,0.057067934,-0.02457416,0.025651855,-0.03714409,0.049101457,-0.060231585,-0.07069702,-0.10694819,-0.09421901,-0.01043195,-0.0011308152,0.084317,0.0050615487,0.083875194,-0.024667518,0.047547482,0.041386742,-0.07962331,0.025150344,-0.0073591727,-0.03126087,0.06253003,0.06431713,0.010309292,0.04720719,-0.0045066373,-0.033419505,0.009293196,-0.053106222,-0.031285048,-0.013675618,0.053813193,-0.05776933,0.023769867,-0.0075284913,0.0032772133,-0.052860636,-0.052885428,0.04899418,-0.07349475,-0.012767129,-0.07299822,-0.027673926,0.02164873,-0.0041187303,0.030991325,0.08345255,-0.01609608,-0.008877929,0.06970903,0.116832905,-0.0163353 +2.7.6.3,"Binds 2 Mg2+ ions that are essential for activity [4]. The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants, fungi, and some archaeal species, including the haloarchaea) and methanopterin (in some archaeal species such as the Archaeoglobi and Methanobacteria). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC 4.1.2.25, dihydroneopterin aldolase [4], the enzyme from the plant Arabidopsis thaliana harbours the activity of EC 2.5.1.15, dihydropteroate synthase [7], while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities [6]. ",384,1.0,-0.062629804,-0.09212393,-0.04559288,-0.036762055,0.090990975,0.051680654,-0.0801847,0.04519302,0.08809263,0.0072272723,0.004888869,-0.100453265,-0.08701295,0.045566782,-0.04272238,0.054226074,-0.095033325,0.0065602018,-0.014424316,-0.0453272,0.06105654,0.03213665,-0.06450782,-0.0061927773,0.0028456235,0.028693376,0.03245027,-0.056337565,-0.043298293,-0.10334357,0.0064589083,-0.024741216,0.075621694,0.0024548932,-0.02597315,0.1586649,-0.00050429866,-0.09725318,0.06317647,0.023134263,0.06906293,-0.0060848515,-0.0026820966,-0.026062386,-0.020427192,-0.010715421,0.08901525,0.0006872687,0.045800325,-0.007058353,-0.027554912,-0.03806148,-0.001186951,0.04543525,0.021506377,0.021095973,-0.019364921,0.06365349,0.012889539,-0.0017488588,0.0756463,0.021764033,0.04956804,0.0029114517,-0.006357796,-0.07484172,-0.0062368778,-0.040765762,0.033907488,-0.073197074,-0.0778493,-0.04569888,-0.030537123,0.014769229,-0.0076181013,0.027883405,-0.020252181,-0.047525298,0.018519282,-0.030723164,0.07496651,0.023616517,0.03177667,0.033733603,0.06430809,-0.039274335,0.008744332,0.020443827,0.041241378,-0.039465524,0.08271916,-0.046669733,-0.011750202,-0.0034775632,-0.024160748,0.046678692,-0.029060198,0.00908605,-0.009476051,-0.022765066,-0.0049150214,0.06464768,-0.050359514,-0.073477745,0.0062115635,0.006308082,0.014034675,0.06192741,0.017423797,0.050618604,0.047867905,-0.040969107,0.019953964,0.06675038,0.034529105,0.07253105,0.042278178,-0.10116176,-0.03552225,-0.0026730923,-0.0029486932,-0.041240484,0.09276461,0.044715296,-0.052325156,0.06281549,-0.1956014,3.9224652e-33,0.046915084,-0.006506857,-0.017886875,-0.001289825,0.04251679,-0.036149886,-0.06770756,0.057676535,-0.029242055,-0.06947499,-0.056680914,0.003957137,0.09857114,0.043057844,-0.009295708,-0.057995297,0.023146672,-0.0050294707,0.07070451,-0.0018158214,0.02303377,0.008712599,-0.06257918,0.059669722,0.11154002,0.02703961,0.009129499,-0.04074605,0.09036722,-0.035270523,-0.02263035,-0.12140659,-0.08411541,0.044885833,0.0696801,-0.008367058,-0.031622764,-0.012071311,-0.06030922,-0.019254293,-0.046948683,0.018544648,-0.03222994,-0.059643354,0.057215765,-0.052318733,-0.041190494,0.056271035,0.05129448,0.024751542,0.047645025,-0.03397023,0.10890059,-0.008488187,-0.044463072,0.03343759,-0.034927607,0.017136332,0.07841752,0.05293135,-0.049160447,0.05402687,-0.047521506,0.031265043,0.023071531,0.06975939,-0.07332806,-0.055001337,0.0067772204,0.09732925,-0.07821984,-0.026323723,0.057309642,-0.01564292,0.033634163,-0.04759713,-0.10871039,-0.010610346,0.019570712,0.041996196,0.048374534,-0.051698893,0.05843451,0.010395571,-0.09592266,-0.024777384,-0.029043304,-0.008596224,-0.0071319905,0.059430815,0.027571535,-0.00631248,-0.05258088,0.007888105,0.04430467,-4.601505e-33,0.09454447,-0.062926024,0.053813893,-0.047268514,-0.038823858,0.14843321,-0.011975284,-0.071135804,0.028941903,-0.08267005,0.081130125,-0.022856714,0.025082707,-0.021250928,0.0024394272,0.008980148,-0.06534744,0.09197792,-0.00944218,0.019287659,0.022614885,0.05701609,0.008876389,0.0027119487,0.085788764,-0.016341884,0.050524224,0.08449707,0.007879954,0.009449079,-0.053998426,0.046344407,-0.049065873,-0.07120176,-0.09540168,0.019163905,-0.090025164,-4.8469552e-05,0.004691039,0.033272874,0.055859335,0.058940507,0.033261273,0.08708373,0.0069287894,0.054148342,-0.054822654,0.05890651,-0.007517344,-0.028864278,-0.0036857554,-0.041708533,-0.07177386,0.043340236,0.045537308,0.050824225,0.030357808,0.03974241,0.0026592447,-0.008203005,-0.025834708,-0.08725796,0.030222755,-0.01431494,0.010302431,-0.013190543,-0.061549854,0.06567344,0.011585437,0.03780226,0.08208275,-0.05078105,0.06422528,0.04093493,-0.025638511,-0.0027141755,-0.064331375,-0.05111162,0.028115718,-0.026016628,-0.014549082,0.0017655216,0.016167954,-0.08964404,-0.016476367,-0.037524696,0.049212683,0.07484655,-0.035916727,0.04873492,-0.033290993,-0.046315264,-0.053099684,0.0107862875,0.02804044,-4.8509612e-08,0.0321885,-0.018969918,0.059882935,-0.07640455,-0.0017522951,0.011547839,0.06905856,0.049156662,0.019837648,-0.025346681,0.00050452293,-0.009250969,0.0032120938,0.018156264,0.07045279,0.016328245,0.015131123,0.019808823,-0.028130267,0.015726615,0.0030223213,-0.052316263,-0.14396079,0.04944573,0.017480152,-0.088957034,0.017116776,0.0499462,-0.0042740367,-0.023026837,-0.05217881,0.05860877,0.026641395,-0.0716132,-0.08932558,-0.0038837316,-0.06879364,-0.055769023,-0.07325511,0.00989699,0.020233158,-0.050566383,-0.06649154,-0.01533223,-0.024685781,0.013946185,0.04586135,0.021175778,0.034600187,-0.006720478,0.054277547,-0.017584044,0.031738907,-0.043791577,-0.09055334,0.03230346,-0.024531912,-0.07670349,-0.027665004,-0.040093116,0.020980584,-0.045241177,0.13750574,-0.06264394 +2.7.6.4,"The enzyme acts on the 5'-mono-, di- and triphosphate derivatives of purine nucleosides.",384,1.0,-0.048332516,-0.07268772,0.0074390117,-0.062340867,-0.01279758,0.0127055235,-0.025718004,0.022364799,-0.0026727756,0.035281535,0.04271499,-0.03365202,-0.09100985,0.048273984,-0.011407533,0.019236969,-0.07716038,0.015036433,0.08317116,-0.060468975,0.056985043,-0.011317355,-0.05533053,0.033719316,0.041992392,0.056252103,0.068640575,0.008474589,-0.025975047,-0.088810705,-0.07634316,-0.038663443,0.039301276,-0.028548649,0.031144712,0.13272612,-0.09668055,0.010144094,0.020062929,-0.0076281973,0.06620057,-0.008490065,-0.02189126,0.02768865,-0.08345128,-0.042067405,0.0064539174,0.06290309,0.06346753,0.061247196,0.021047382,-0.08087539,0.017738765,-0.061357975,0.01852389,0.004258583,-0.081837766,0.018083535,-0.015809692,0.03972494,-0.008923246,-0.031898275,-0.055363107,0.0055454387,0.038686275,-0.026169924,0.07525801,-0.0050535435,-0.015919283,0.029816233,0.0046648923,-0.060739253,0.004225748,-0.041056152,-0.043223467,-0.015225154,-0.031499907,-0.054536782,0.02739394,-0.0023218486,0.013259515,0.04697097,0.06686613,0.009738793,0.047655437,0.06342722,-0.055867895,0.020979393,0.020056328,0.011933569,0.045510225,-0.015078924,-0.01710602,-0.052416686,-0.007946173,0.05814919,-0.08532111,0.05164133,-0.006176949,-0.028928144,0.08863088,0.08048778,-0.08122954,-0.06401615,0.04764278,0.061581824,0.046051063,-0.036679965,-0.012222665,0.050080337,-0.05268033,0.0073396033,0.018423665,-0.0086270515,-0.04341498,0.052207865,-0.030450255,-0.054763094,-0.027039478,-0.04552722,-0.001074092,-0.032169484,-0.02642984,0.0862998,-0.09054382,0.05227802,-0.06113749,-3.174237e-33,0.042758945,0.040815514,-0.019712925,-0.007160059,-0.0070065195,0.017142858,-0.010930867,-0.004264018,-0.118414976,0.02891883,-0.08345789,-0.061121665,0.044881303,-0.03295684,0.004085147,-0.06490349,0.020338865,0.09935395,0.071000695,-0.008326631,-0.0048067314,0.09102748,-0.05223618,0.04849428,0.00021105063,0.023716547,-0.11180994,0.08415355,0.1359022,-0.039679326,-0.0072578792,-0.031356238,-0.066813335,0.008668132,0.06974758,-0.04179712,-0.07676343,0.037190706,0.012007006,0.026637647,-0.0066342666,-0.038099784,-0.061532218,0.023921514,0.024863161,-0.035835918,-0.038416304,-0.004397725,-0.002757157,0.024372842,0.0036694163,-0.025354773,0.08893477,-0.071873374,-0.037320085,0.021697741,0.013465356,-0.020501155,0.010219134,0.07458322,0.011170607,0.053256907,0.028195083,-0.04978558,0.029556645,0.06774166,-0.07982044,-0.050130717,0.06142939,0.10891393,0.008707409,-0.01688921,-0.019769711,-0.01715667,0.060941033,0.0055435495,-0.07440963,0.033885438,0.0031040793,0.02358027,0.0326805,-0.04741137,0.035015937,0.017684486,-0.037366502,0.0027581144,0.039639864,-0.08330909,0.03411651,0.0050729797,0.12664902,-0.060535308,-0.038106564,-0.010547528,-0.005675642,1.0331204e-33,0.058829814,-0.058746535,-0.014072964,-0.055614322,-0.13603166,0.034756254,0.022351542,-0.09066185,0.029862281,0.05590426,0.0514917,0.0060402337,-0.105843805,-0.07064617,-0.042672988,0.1042128,0.01811003,0.063904434,-0.041073576,-0.0054599633,-0.025589969,0.09391081,0.03641523,0.09137656,0.01858282,0.00045729344,0.08752331,-0.0220943,0.09924263,0.027218511,-0.06840282,-0.020855412,-0.051137287,-0.018646315,0.038406663,0.014045524,-0.048738874,0.026768146,0.017125748,-0.0050322837,-0.010185371,0.06508765,0.06413599,0.06277501,0.038134,0.028583914,-0.07125852,0.06463394,-0.12769593,-0.10546346,-0.00659198,0.0119393375,0.038171828,0.028465105,-0.0018495894,0.0004812637,0.020071091,-0.0017116796,0.026945416,-0.04355884,-0.045518693,-0.08460529,-0.047225762,-0.023957936,0.0019840607,0.040437263,-0.0730988,0.019638592,-0.024733404,-0.010899911,-0.074952036,0.003586676,0.027637746,0.02432292,-0.08620893,-0.035408057,0.039002962,-0.044153087,0.07749711,-0.052849855,-0.011765877,0.007913069,-0.057194293,-0.058696773,-0.009186506,-0.08595368,0.06554764,0.097027965,0.03925719,0.10210192,0.03393651,-0.030925333,-0.014064118,0.06673915,0.066125356,-2.5832188e-08,0.07593776,-0.082582876,0.027850544,-0.051173966,0.011462288,0.042255007,-0.0064510093,-0.020731168,0.07055005,0.035268433,-0.06088997,0.04189141,0.07721685,0.033894792,0.08210823,0.07994399,-0.03121177,0.027404955,-0.010325947,0.0048681563,-0.0675642,0.05052375,-0.10362858,0.05588419,0.040225755,-0.012889417,0.04691983,0.046896737,-0.014582118,0.008027653,0.021508789,0.051373765,-0.0359089,-0.08333636,0.029360088,0.069945,0.00954057,-0.015370591,-0.046280902,0.045750793,-0.081811085,-0.04567546,-0.031922653,0.019399673,-0.042945985,-0.012305883,0.016375229,0.028564053,0.052781947,0.043163665,-0.00065278506,0.014480218,-0.024990335,-0.0612528,-0.026504196,-0.075346775,-0.028609946,-0.091220394,-0.027898308,-0.027770901,-8.7749984e-05,0.029101854,0.16998951,-0.06393416 +2.7.6.5,GDP can also act as acceptor.,384,1.0,-0.023360098,0.010043193,-0.029214557,0.024192745,0.04617322,-0.028647983,0.073905244,-0.060227558,0.049918123,-0.016017504,0.108031176,0.015573599,-7.3415526e-06,0.029321775,0.01795197,-0.0012288368,-0.01048716,0.005702841,-0.0010832456,0.047512554,0.017390529,0.001965739,-0.012139534,-0.06465623,-0.017127385,-0.09420535,0.013719969,-0.07542312,0.012488712,-0.0200342,-0.009500291,0.022133783,0.02674288,0.11830985,-0.03682541,-0.03237609,0.06342762,0.0368401,-0.042203926,-0.093601964,0.021090563,-0.07414799,0.017014619,-0.0577311,-0.01568124,0.06658071,0.060633987,-0.006615722,-0.06740141,-0.018605076,0.009458002,0.09443035,-0.029662445,0.049134124,-0.020767236,0.04082005,-0.027770732,-0.03792285,-0.015146844,-0.006391331,-0.07132896,-0.02481795,-0.044583257,-0.038744494,0.12215281,-0.019422125,-0.019595858,-0.037525482,-0.16581544,-0.0054456703,0.07800465,-0.08073779,-0.03487534,-0.018941866,-0.017014815,-0.06490769,-0.03240591,0.081410535,0.07671886,0.014581964,-0.038542125,0.06592578,0.0066860258,-0.057553627,0.034470707,-0.018914567,-0.067915305,-0.04082359,-0.024497963,0.026799282,0.015328376,-0.035305947,0.06325041,0.02266401,0.079312146,-0.038078062,0.046689853,-0.0046220855,0.052134525,0.005288686,-0.0118400855,0.07910226,-0.060343158,0.03139647,-0.06850701,0.00033147406,0.020416042,-0.011692807,0.012530756,0.016076844,-0.07315808,-0.04808798,0.061376136,0.02869401,0.003700942,-0.058526672,-0.039034415,-0.037129447,0.055467095,-0.046782564,0.040456403,0.047936656,-0.034625668,0.0048258584,0.0016018093,0.02004103,0.01233189,-4.2062935e-33,-0.10834987,-0.01782697,-0.026521232,-0.054515637,-0.06779165,0.046293635,-0.10383566,-0.008448498,0.0017747881,-0.008038142,-0.06087494,0.043043125,0.044553496,0.09066204,0.051958058,0.031844277,-0.0133432215,0.13657756,0.12234695,0.029130721,0.0747203,0.0374726,0.014213224,-0.029182926,0.0452142,-0.009922861,-0.088653475,0.01652017,0.0613825,-0.021883119,0.13149919,-0.0086712465,0.015582346,0.009755385,-0.034613468,0.028190607,0.048313603,0.03546957,-0.05967606,-0.098480865,-0.04765144,0.03723818,-0.08697654,0.04773302,-0.041804332,0.03943252,0.078862354,-0.09364248,0.03880362,0.04724858,-0.028051954,-0.0048690713,-0.07394025,-0.15007639,0.018955657,-0.0039103217,-0.007940862,0.028907062,-0.0006073965,-0.033591647,-0.0861147,0.007024552,-0.025686169,0.020806547,-0.021437673,0.07402753,0.057893302,0.012131201,-0.0057831183,0.049181215,-0.034392685,0.016705716,0.010878633,0.063023336,-0.045978077,-0.0039116917,-0.002685512,0.00045579087,-0.025187833,0.0127171,-0.11587299,-0.07565182,0.0393971,0.022791239,0.016016115,0.060734272,0.0137666585,-0.026007038,0.06925332,-0.008458631,-0.048755575,-0.01144928,-0.07489288,0.0792938,0.026173446,-1.1646922e-34,0.014874024,-0.02136853,-0.066800706,0.027649174,0.057513036,0.053724486,0.024081646,-0.03172209,0.023301736,-0.04325369,0.012904631,-0.039421767,0.04954263,0.082161725,0.042472254,-0.03345006,-0.009895957,0.02294416,-0.055666834,0.014481284,-0.095957346,0.052338917,0.051707353,0.0741288,-0.022395091,0.05131349,-0.12740195,-0.04743989,0.011371903,-0.01508818,0.019066932,0.009984611,-0.036144912,0.003463893,-0.044789635,-0.018408982,-0.067886055,-0.037002277,-0.018626107,0.008812458,0.0021980377,0.0073546227,-0.06597781,0.08453985,-0.009830634,0.008876407,0.10869455,0.031953685,0.023540223,-0.14003265,0.06870547,0.08546009,0.011838094,-0.07794052,0.0374631,0.074815154,0.098389745,-0.09152777,-0.020251757,-0.07072386,-0.0047524283,-0.07915515,0.031499542,0.079211414,0.012186854,-0.034346085,0.020985052,0.00265549,0.1346824,-0.010519246,0.07321419,-0.11800153,-0.042922113,0.050911978,0.03707706,0.02497634,0.010795589,0.003576163,0.027815245,0.027086634,-0.0776019,-0.0007490255,0.042328786,-0.08375901,0.0228761,-0.08119007,-0.03747089,-0.13359478,-0.01962721,0.0377998,-0.102469996,-0.052776925,-0.06259489,0.0105276555,-0.067026965,-1.9327725e-08,-0.03205645,-0.00939469,0.073255844,0.012853317,-0.04583626,-0.055295102,0.010182896,-0.033599872,-0.032793805,0.055483405,0.022811353,0.011288888,-0.020085614,-0.03189631,0.02224585,-0.0008890506,0.004283763,-0.012583952,-0.0320074,0.04636703,-0.024461757,0.061723318,-0.030851427,-0.085831486,0.048601426,0.015528174,-0.02507672,0.045027167,-0.03502499,0.0722565,0.011472346,0.0052612964,0.0010162897,0.007970432,0.03535775,-0.005441527,0.09908664,-0.030577892,-0.010982789,-0.06948965,0.057335034,0.010073391,-0.030871427,0.03726446,-0.035935953,0.043178853,-0.031125536,-0.063931644,-0.015771274,-0.060286134,0.035627916,-0.0074468153,0.062722586,0.010266525,0.03924008,-0.052203704,-0.026446216,-0.007830809,-0.0344625,-0.005537793,0.052287303,0.013239371,0.10788191,-0.042280428 +2.7.7.1,Nicotinate nucleotide can also act as acceptor. See also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase.,384,1.0,-0.06470994,-0.0061547277,-0.02487192,-0.0271505,-0.02317905,0.015552168,0.03177423,-0.010843563,0.04059147,0.03425614,0.0564661,-0.017427117,-0.12755264,0.049097594,0.038590413,0.026161522,-0.08548677,0.07795788,0.049673297,-0.012078212,0.028466243,0.081424735,0.003809495,-0.04392956,-0.04317539,0.0070493105,-0.050969463,-0.025109226,0.026736004,-0.08261761,-0.08574451,-0.06331035,-0.021824427,0.048003353,0.012265929,-0.018916674,-0.08630788,-0.014647742,-0.039820928,0.008846953,0.07681664,0.011551698,-0.014735392,0.052341253,-0.07453051,-0.0030031109,0.046800774,0.0036316786,-0.030127488,-0.043693896,-0.017496727,0.0036018621,-0.033990063,-0.026199788,-0.017396294,0.093249775,-0.08786045,-0.03090982,0.03185205,-0.03292159,0.015718477,-0.0526801,0.003915587,-0.061714116,0.09356556,-0.09154708,0.10603188,-0.053524405,-0.03234126,-0.044910394,0.008959078,-0.056176603,-0.004541325,0.02705532,0.037940446,0.06687343,-0.11091607,0.013535779,0.089317136,0.08565061,-0.0070855594,-0.01673484,0.003589672,0.035935372,0.03949631,-0.024300663,-0.036757614,0.0870692,-0.021186028,0.06863759,-0.027570352,-0.01897994,0.03741935,-0.015430158,-0.067446634,-0.04703142,0.1149476,0.06104929,0.015635617,-0.045220446,0.020075774,0.11580328,-0.10082107,-0.031845015,-0.049759656,0.0050046006,0.025125157,-0.042612303,0.0027881558,0.008250344,-0.03353052,-0.0797522,0.038199984,-0.024381949,-0.03629596,0.06266579,-0.052390672,-0.064813405,0.06821198,-0.020217111,-0.06152984,-0.022853015,0.027062122,0.064966455,-0.00511011,0.019339768,-0.047486395,3.2715587e-33,-0.043649934,0.038647123,0.015991867,0.020887809,-0.035586532,0.02245867,-0.06322169,0.025403058,-0.07780094,-0.09919258,-0.05488492,-0.14108679,0.06946316,0.0698756,-0.0031671692,0.037940927,-0.045470137,0.0067557283,-0.0023157755,-0.085285105,0.014903828,0.05128196,-0.051960256,0.020394213,-0.045590576,0.013373468,-0.1269753,0.029588396,0.100157425,-0.014429753,0.07325121,-0.02337581,-0.03203422,-0.010320962,0.05780956,0.030673677,0.080613166,0.0062194373,-0.032752685,-0.0010326653,-0.030961413,0.026680738,-0.026085129,-0.008796409,0.052153476,-0.035503432,-0.03256799,-0.052401472,0.030747596,0.029546171,-0.03210441,-0.08311497,0.05985107,-0.07468247,0.02006402,-0.0018600527,0.027543416,0.041001186,-0.1145482,0.04841813,-0.016783444,0.02330637,0.0011438823,-0.026826322,-0.06439553,0.008326207,-0.043474272,-0.123245664,0.014950052,0.05986407,0.016220706,-0.018397812,0.04230589,0.001476067,0.032872397,-0.04956182,-0.04294611,0.037758294,-0.053791128,0.05815826,-0.10184687,-0.049189605,7.142463e-05,0.010021306,-0.0055665234,-0.07395304,0.07990901,-0.08217685,0.059329342,0.08540386,0.025188683,-0.024317512,-0.041070603,0.013725673,0.09103158,-4.883427e-33,0.026220268,-0.008718284,0.033495076,-0.0047108103,-0.023940999,0.10173669,0.030607164,-0.04775167,0.056911968,-0.056925744,0.04256944,0.00873952,0.10766637,-0.021210138,0.027618779,-0.030346947,-0.03759221,0.068809755,-0.010035305,0.043987174,-0.05911287,0.034084342,0.0081966845,0.03685841,0.050884623,0.01678238,-0.03602607,0.021618031,0.020253358,-0.03891488,-0.062233604,0.06598996,-0.024980549,-0.025714444,0.010846299,0.007768976,0.0051237755,0.03058233,-0.08321392,0.03545266,0.010694223,0.038146593,-0.0024031117,0.08398269,0.020493446,0.011862268,0.087458864,0.043434657,-0.030749809,-0.014578076,0.044539593,0.060329705,-0.014286822,0.06577903,0.10531678,0.09115457,-0.00821674,0.0025569054,0.02711033,-0.0027100183,-0.034782678,-0.10340768,0.00028222194,-0.07687079,0.08386013,-0.026362065,-0.0638817,0.067392945,0.08101381,-0.06855339,0.058742363,-0.002693906,0.04996154,0.046443988,0.030593228,-0.05532826,-0.032581862,-0.0365658,0.005279392,-0.09288853,-0.057535898,0.07758385,0.008728639,-0.04561921,0.06907682,0.0055688843,0.04595702,0.0018171773,-0.07393658,0.0230694,0.0069088736,-0.027984926,-0.0073906146,0.02807179,-0.05386107,-3.298981e-08,0.045138232,-0.047011945,0.015552459,-0.06347088,0.021821596,0.060158387,0.009042431,0.012447089,0.012228083,0.077709764,0.0025814604,0.05860735,0.063458525,0.023392087,0.09520663,0.013663073,-0.033691064,0.020953398,-0.048985038,0.035097685,-0.14344116,0.02396426,-0.06064978,0.0033678678,-0.048114054,0.04157844,0.027010255,0.038937476,0.017912015,-0.0373162,0.060460582,-0.019458134,0.07540297,-0.06082932,-0.061909355,-0.01087545,0.09090815,-0.033010755,-0.040399317,-0.005772759,0.04751928,-0.07120919,-0.07486607,0.044622295,-0.023203788,0.04257682,0.010561092,0.003913278,-0.06257476,-0.020048121,0.0073025585,-0.033501986,0.04618185,-0.08059283,-0.08523942,-0.06910202,-0.008291644,0.00038383316,0.021568503,-0.030264148,0.088618726,-0.009435228,0.13597266,0.014724935 +2.7.7.2,"Requires Mg2+ and is highly specific for ATP as phosphate donor [5]. The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates [3]. While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26, riboflavin kinase [3,5].",384,1.0,-0.08214135,-0.07152197,-0.08130721,-0.027308121,0.06944919,-0.037316628,-0.05915715,0.022239918,-0.022458982,0.025437808,0.01768813,-0.028194102,-0.047663156,0.011332923,-0.016123766,-0.06333444,-0.08403777,0.03919403,-0.00896143,0.007345442,0.01679162,0.03576933,0.003180568,-0.054415114,-0.0071002054,-0.03508307,0.06210898,-0.06516824,0.035147965,0.006210791,-0.053949375,0.02636942,-0.0015020921,-0.03739123,-0.017344031,0.12873457,0.03832053,-0.05315161,0.0034895025,-0.03864857,0.029442623,-0.014464757,0.07768554,-0.046504766,0.012587865,-0.0268313,0.07836361,-0.019261358,0.043284465,0.02615826,-0.043074,-0.0305889,-0.08590576,-0.015803466,0.06919668,0.044615276,-0.017005699,-0.05797556,-0.011432455,0.045434106,-0.048675958,-0.028667634,0.011162079,-0.02806226,0.13076475,-0.00221813,-0.035570037,-0.051016446,-0.017607609,-0.052206002,0.012464774,-0.042122845,0.012340896,-0.03774769,-0.021237262,0.09527879,-0.09523909,-0.04594645,-0.008107721,0.018797077,0.0433841,9.6299744e-05,0.077564925,0.025572032,0.041335914,-0.07990384,0.0019619577,0.04760931,-0.059681,0.09459536,0.040716227,0.057502657,0.062305354,-0.05461497,-0.10618997,0.06740604,0.012505469,0.04464581,0.016691191,-0.04250702,-0.0048730774,0.08458792,0.03772694,0.04802634,-0.039229028,-0.020081008,-0.020530393,0.09684662,-0.0040589105,0.045800526,0.050044496,0.06813722,-0.0021787223,-0.042848073,0.013465307,0.058737367,-0.04330395,-0.11937249,-0.010314043,0.03475151,-0.042825084,0.03104354,0.04104124,0.057841174,0.003921262,-0.01152135,-0.120425865,3.187714e-33,0.003988718,0.033233967,0.033726964,-0.0018537063,-0.041052923,-0.02229116,-0.09017644,-0.06387735,0.047257256,-0.09327917,-0.09807661,-0.008167096,0.053194106,-0.013644689,-0.041164555,-0.07785793,-0.047697667,-0.063651025,0.10415858,0.024128843,0.09808467,0.02857338,0.07498459,-0.010891461,0.04085425,0.03415209,-0.00012374824,0.030466788,-0.008831134,-0.0033271092,-0.021280313,-0.12900299,-0.05530824,0.034330454,0.02073698,-0.037444822,-0.0835123,-0.037474908,-0.07401186,0.047194194,-0.014016857,-0.04897304,-0.060856655,0.015366716,0.07261997,-0.06290378,-0.013034223,0.044160582,-0.019881278,0.06658466,0.040321164,-0.052951977,0.012397481,-0.01043952,-0.058288507,-0.03859284,-0.019861875,-0.040901136,0.043349713,0.074520454,0.027906418,0.0396486,0.013274452,0.09222648,0.0002544345,0.033636093,-0.07877368,-0.12001796,0.025574502,0.1062596,0.07061411,-0.09133517,0.11994731,0.029817792,0.02687072,-0.022500647,0.0041265185,-0.0049078753,-0.052977305,0.056409534,0.059185,0.0014593112,-0.034105755,-0.004177501,-0.062457897,-0.007320998,-0.050743707,-0.08903514,0.011312801,-0.007839163,0.10020445,-0.038058467,-0.027321054,0.002999782,0.005733856,-3.9360392e-33,0.09052209,-0.064020425,0.08382889,-0.10702334,-0.07037107,0.07665024,0.052520372,-0.0890676,0.07959401,0.019657021,0.016328843,-0.004727819,0.021443488,-0.08087155,-0.053015716,-0.04405807,-0.015223098,0.032342695,0.05833528,0.013219288,-0.03541601,0.10169233,0.03354569,0.065421745,0.020051405,0.050013114,-0.019095888,0.011992573,0.014549916,0.054128505,-0.012619089,0.06728364,-0.07233698,-0.026143225,-0.044655655,0.00071852776,-0.0451738,0.023797592,-0.02921193,0.026805716,-0.0058834506,0.08029923,0.05702622,0.053126387,0.019292159,-0.011283321,-0.035047773,-0.021438302,0.031307187,-0.090666234,0.04307656,0.017079636,-0.05331753,-0.04158231,0.029552137,0.03530297,0.042639937,0.0730911,0.09126174,-0.01539777,-0.012097575,-0.1053422,0.09225235,-0.046518803,0.03508118,0.04485559,0.04800328,0.04219961,0.0044103577,0.11714033,0.030109461,0.025305927,0.06463727,0.033667605,0.025632054,0.075875826,-0.026900496,0.030044286,0.0061032553,-0.0006505867,-0.0089834565,0.033930708,-0.078918904,0.008416006,-0.06228957,-0.10957399,0.015652476,0.060410812,-0.0018383758,-0.041794267,-0.027107228,-0.01389373,-0.041374706,0.0019217386,0.050545257,-4.415834e-08,0.00022704322,-0.017246475,0.010282257,-0.046043962,0.054747764,0.048480272,-0.03360885,-0.026174808,0.09087795,0.0038456877,-0.034866907,0.063794136,0.033379886,-0.028571498,0.0009806012,0.02081834,-0.056117043,0.033529215,-0.04078037,-0.034139976,-0.003720202,0.0025246819,-0.11441354,0.06186086,-0.02271691,-0.05244628,0.0041423994,0.030954158,0.014478315,-0.01067775,0.012646236,-0.008147705,0.013449123,-0.069663025,-0.073107935,0.0073190485,0.049445268,-0.004704539,-0.095318586,0.03116712,-0.07641622,-0.053736616,-0.03918382,0.01471437,-0.05709011,0.019365482,-0.0035108274,0.062080532,-0.043364804,0.010507884,0.059741873,-0.022610405,-0.031144459,-0.06560762,-0.06744636,0.005129382,-0.008905085,-0.07052291,-0.018324453,-0.04465118,0.056441102,0.024411257,0.12141005,-0.03469109 +2.7.7.3,"The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase.",384,1.0,-0.059270203,-0.09954103,-0.1057569,-0.03758116,-0.006287345,0.030038925,-0.027164333,0.023421027,0.052196585,-0.000105982734,0.03942126,-0.047822654,-0.005207042,0.034490187,-0.031663317,-0.0075456924,-0.05425093,-0.020727409,-0.008034463,-0.06649524,0.11867359,0.044903588,-0.0776538,-0.04477797,0.010997236,0.008445079,0.054277126,-0.04416749,-0.046138328,-0.10143254,-0.0403571,-0.08029742,0.08197079,-0.043130867,0.095069,0.081489034,-0.04067133,-0.10691416,0.11856559,0.01438502,0.018416408,0.0324862,0.020242916,-0.10229103,0.021011416,-0.024119316,0.087248415,-0.0109269265,0.025830584,-0.0063335644,0.016070774,-0.012685574,0.03604795,0.043656956,0.052739076,-0.011917015,-0.10224402,-0.034547817,-0.024087764,0.061437283,0.037688676,0.023564104,0.061232813,-0.035979215,0.0079956455,-0.07375833,0.10233449,-0.13496864,-0.015242909,-0.00690176,-0.1188833,-0.057523277,0.0025666493,-0.0031612334,0.08033735,-0.017930849,-0.050980534,-0.011544452,0.04324831,-0.04136062,0.036454782,-0.07399456,-0.012863134,0.10230277,0.019938756,-0.008367273,-0.005302272,0.014491359,-0.00083389424,0.015151715,-0.03237336,-0.07662736,0.04671712,-0.059093066,-0.0037819224,-0.00033512642,-0.0310004,0.063151844,0.059753608,-0.042641953,-0.0030464286,0.113365486,0.060841594,-0.010522381,-0.02291772,-0.015859518,0.04556076,0.13627099,0.05538406,-0.022615101,-0.06242084,0.010292596,0.036255766,-0.020898515,-0.057986952,0.08322024,0.011387433,-0.09306501,-0.039369572,0.043501798,0.07190123,-0.03413025,0.047537357,0.11125142,-0.03571439,0.059143055,-0.03347235,2.1708262e-33,0.049165085,0.035926256,0.04770243,-0.03189979,-0.01015076,0.005149688,-0.101657115,-0.007903289,-0.0055575874,-0.078417055,-0.060980573,0.0012054987,0.092264384,0.06679328,-0.0010456203,0.055633675,-0.0465763,-0.040374216,0.10900893,-0.027874073,0.053021472,0.024333326,-0.020204144,0.029793246,0.010541778,-0.008804562,-0.0036046251,0.052135732,0.046837773,-0.027315384,0.0033322917,-0.06496689,-0.07940046,0.018243002,0.009209443,-0.04747691,-0.030009257,-0.005177788,0.024231931,0.014821141,0.024851847,0.06280566,0.028210081,-0.0487218,0.03340485,-0.065880015,-0.04876163,0.07797935,0.04823906,0.10367328,0.017700316,-0.058043104,0.12900625,-0.07417769,-0.01740219,0.031881817,-0.01265126,-0.020540126,0.021055015,0.07811622,-0.031897217,0.057268582,-0.029957091,0.0057228087,-0.037492406,0.046129413,-0.030673636,-0.05330625,0.019343587,0.059855055,-0.060937837,-0.013187845,0.009022686,0.010099915,0.007505688,-0.02439661,-0.10072147,-0.0042375866,0.033529423,0.02964904,-0.0016241833,-0.012892356,0.07957516,0.009125817,-0.06553885,-0.04427699,-0.025799934,-0.074940674,0.040600196,0.10160796,0.011141379,-0.048122007,-0.08508272,0.039014418,0.028886901,-3.857348e-33,0.088635124,-0.06553855,0.019292552,-0.07839067,-0.08563339,0.08192816,0.006390813,0.0018287917,0.0019403695,0.042231843,0.0917043,0.036080625,0.048912942,-0.068090655,0.027889723,-0.026373396,0.013866393,0.07111305,0.03318083,0.029082078,-0.0006251634,0.035064235,0.013498527,0.001961918,0.02001323,0.052069303,-0.0030743205,0.033596553,0.026219228,0.017843751,-0.07834527,0.0067563383,-0.028847292,-0.021000722,-0.073255345,0.01942916,0.008724413,0.052595276,-0.0028790215,-0.04926119,0.011235412,0.0799317,0.047911655,0.042583156,0.033401765,0.08281566,-0.0076601524,0.027079092,-0.086413674,-0.05244794,-0.044882607,0.0243274,-0.02602123,-0.06161166,0.02705657,0.040346373,0.0041555264,0.014752164,0.020979475,-0.031219225,-0.043509893,-0.016284509,-0.009211589,-0.062160328,0.026238453,-0.007375096,-0.033718698,0.04424811,0.056075476,0.008555233,0.045494188,-0.034789413,0.05836603,-0.024270728,-0.007975941,-0.031689413,-0.100782916,-0.059365988,0.03448369,-0.018373713,0.036584504,-0.019081235,-0.02589131,-0.07459029,-0.028224032,-0.05716249,0.028384332,0.08692973,0.022521066,0.002720918,-0.06242871,-0.011461244,-0.059588276,0.0056098993,0.013334758,-4.0740172e-08,0.06899542,0.000860888,0.023469983,-0.039225265,-0.0061943773,0.061772972,-0.030671842,0.04776191,0.04779264,-0.0039918106,-0.012169906,0.08007224,0.00964316,-0.045026537,-0.043504253,0.0057189176,-0.036181293,0.028670495,0.014045512,0.01172909,-0.0678382,-0.026781097,-0.11803812,0.03459823,0.021059765,-0.094460584,0.030317457,-0.036201674,-0.017856658,-0.041853987,-0.05215921,0.021773618,0.024610694,-0.077524,-0.08717149,-0.068878986,-0.018568216,0.005271272,-0.03627181,0.028843626,0.073394835,-0.0011959297,-0.11221879,0.024810148,0.03796226,0.069337346,0.0074147377,0.010128354,-0.0332176,-0.06170632,0.02967886,-0.09360547,0.0043517775,-0.052604906,-0.120913014,-0.013937291,-0.00969597,-0.08482103,0.053939823,-0.004651133,0.0013111881,0.032105036,0.1434295,0.007057227 +2.7.7.4,"The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25).",384,0.99999994,-0.07566168,-0.016243858,-0.020009065,-0.083987735,-0.02858659,0.026179671,-0.052436493,0.030618787,0.115791455,0.06972336,0.0022589052,0.026304506,-0.0687417,0.003051408,-0.0852585,0.035865422,-0.116220035,0.07427605,0.044375833,-0.036493503,0.11151035,0.023655226,-0.07690089,0.035594754,0.025454063,0.0555111,0.05634537,0.00022324403,-0.06260662,-0.04263927,-0.053675834,-0.07519635,0.0054307166,-0.058402058,0.0049214675,0.17296568,-0.01675665,-0.058863953,0.04620948,-0.08304077,0.036500014,-0.029546537,-0.07152737,0.02458679,-0.0005148039,0.028980661,-0.037219524,0.05006063,0.029035185,-0.11583222,-0.0040940014,-0.033136237,-0.037421726,-0.022359727,-0.0006571638,0.011620271,-0.09340276,0.048895627,0.037277456,-0.043648776,-0.08230309,-0.0030335148,0.036403365,0.055661213,0.05600531,-0.0015803338,0.052354887,-0.03870364,-0.025668139,-0.0043530934,-0.12601005,0.0068353084,0.05672709,0.062220387,0.003834704,0.04999932,-0.057446018,-0.02221975,-0.011531507,-0.0084317215,0.08231811,0.04967403,-0.021456175,0.028352167,0.0256547,-0.035333898,-0.022350678,0.03684092,0.038545575,-0.0026235147,0.027125197,-0.022729354,0.039761573,-0.013254501,0.0066094426,0.06274952,-0.03004104,0.08429267,0.017974509,-0.0682171,0.007696355,0.069405295,-0.0031979317,-0.11786632,0.043454576,0.008208834,-0.009899621,0.03481061,0.03340735,0.06739294,-0.042542707,0.037133142,-0.018810468,-0.047517747,0.019985322,0.093235776,0.0017816916,-0.11296744,-0.0670759,-0.008102727,-0.06927412,-0.07676256,-0.012135815,0.080239974,-0.025101105,0.029912792,-0.07961001,3.9764333e-33,0.055414446,0.049847953,0.09582537,0.005754682,-0.013073371,-0.04452387,0.0249575,-0.027537605,-0.017447589,-0.056045238,-0.06991326,-0.06973482,-0.012123835,-0.010469388,0.008070781,0.06105452,-0.038564928,0.059759226,0.09056737,0.0038513592,-0.07240225,0.01390483,-0.020780481,-8.710132e-05,0.038338754,0.06536856,-0.08829036,-0.023257375,0.0066621844,-0.03651779,0.035315927,-0.03100566,-0.090667024,0.021430964,-0.0035907258,-0.046490323,-0.061317757,-0.01592181,0.036709953,0.065412894,-0.07752204,-0.024261106,0.029169101,-0.021880997,0.03665845,-0.018878464,-0.09546405,0.05529411,0.00040458015,0.09288613,-0.011172385,0.020510383,0.09423578,0.008396304,-0.028319832,-0.032920565,0.0020783588,-0.08639244,0.0013355137,0.035938483,0.054679852,0.0858284,-0.007162903,-0.03358409,-0.05668971,0.0027102625,-0.07881053,-0.026405668,0.023967134,0.11511354,-0.010247972,-0.057027355,-0.0043405034,0.019714793,0.012015363,5.4590833e-05,0.01402109,0.030407175,-0.031564575,0.071449436,0.0044783037,-0.039087046,-0.02630221,-0.007488947,-0.05914533,-0.0040297974,0.02197424,-0.029342119,-0.03849231,0.05554378,0.016915288,-0.049522255,-0.056344334,0.07248323,-0.033350393,-6.173142e-33,0.14332855,-0.0255019,0.043436088,-0.117145285,-0.068886384,0.013450385,0.015915202,-0.040971193,0.04445591,0.013734835,-0.012141929,-0.005382206,0.06653177,-0.02183336,-0.023161735,0.019747281,0.029440776,0.07480914,0.008823727,0.020984769,0.03352755,0.13456294,0.00091357634,0.1038333,0.040845215,-0.03447872,0.008076365,0.033213317,0.03541054,0.013787606,0.011086958,-0.029736588,-0.032707043,0.0008662499,-0.043902896,-0.0070822802,-0.05432102,0.018349428,0.03874017,0.014011857,0.042779446,0.052100986,0.014411404,-0.0014436109,0.010440513,0.04768451,0.026732769,0.02938065,-0.056047425,-0.073735245,0.038688555,0.06744151,-0.025464393,0.061394513,0.020919658,0.056976028,-0.008463638,0.069750525,-0.017042538,-0.071013086,-0.1005276,-0.09686014,-0.0217439,-0.02508815,-0.02202014,0.054941174,-0.037434533,-0.06362553,-0.016931277,0.029827131,-0.08457333,0.0131582795,-0.02118002,0.0045483653,-0.03300579,-0.024238573,-0.04458418,-0.04096287,0.025866885,-0.033647124,-0.047986392,0.016493946,0.008017948,-0.100130655,-0.03889407,-0.040634323,0.035978746,0.05167,-0.03699817,0.014000239,0.010299158,-0.009526446,-0.07020664,0.03715167,-0.031033652,-4.3424365e-08,0.025650376,0.01678255,0.05833575,-0.014795647,0.014955824,0.026946498,0.07654869,0.05601217,0.03979092,-0.00046823017,-0.038341105,0.066185854,0.048115667,0.0132871065,0.08505209,0.009580031,-0.060066402,0.025031473,-0.013707557,-0.08185599,-0.04549576,-0.042380575,-0.09780862,0.11763113,0.08780557,-0.0017521182,0.06526511,-0.038479265,-0.04189929,0.029613178,0.039797448,0.01909132,-0.059007667,-0.054881163,0.07709539,0.029289773,-0.052174024,-0.010903129,-0.0068810745,0.03357764,-0.067899816,-0.014730336,-0.046465967,0.053626988,0.04327951,0.052277494,0.01965666,0.019554146,-0.023041863,-0.017664593,0.1150806,-0.053082272,-0.029550346,-0.13233902,-0.043835226,-0.017126678,0.04870316,-0.071077935,3.7213114e-05,-0.05459065,0.06997335,-0.023460986,0.13100398,-0.019317493 +2.7.7.6,"Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).",384,1.0,-0.042467527,-0.031654045,-0.036064655,-0.021354903,0.0064977095,0.012237273,-0.090533204,0.04008554,-0.011279684,0.040721867,0.0032405634,-0.0057186913,-0.10094382,0.011160108,-0.06506172,0.053335857,-0.21169907,0.012410845,0.076338455,-0.056335155,0.07788903,0.025662784,0.020404443,-0.008059094,-0.022416893,0.048967324,0.06456895,-0.034260318,-0.021864321,-0.08757531,-0.032601256,-0.105028376,0.035231244,-0.014975263,0.06192019,0.02763999,-0.05300999,-0.056428473,-0.012961359,0.04841268,0.09630136,0.02968652,0.008050168,-0.027565364,-0.04507625,-0.063287,-0.056982324,0.003228577,-0.0074454327,0.043660734,-0.013358975,-0.07104976,-0.05205062,-0.063159645,0.05832285,0.029261276,-0.023847565,-0.03808457,0.024088264,0.046401363,0.08853705,-0.032870688,-0.039734967,-0.064834155,0.09027225,-0.061686356,0.11664921,-0.01798883,-0.020719955,0.02772183,-0.0030013195,-0.048279893,-0.07210157,0.06674134,-0.0002528145,-0.010356487,0.014259335,-0.0126283765,-0.010398477,0.03041756,-0.038634997,-0.004640487,0.031030258,0.028010912,-0.017403223,0.059943024,-0.033357266,0.06624213,-0.01579447,0.091398805,-0.039720204,-0.02310797,0.004615791,-0.040672634,0.030410953,0.07142845,0.045651495,0.085385926,0.07064256,-0.062429246,0.071547605,0.06266417,-0.08567428,-0.058920644,0.008949108,8.39999e-05,0.013981382,0.0006911161,-0.0067439075,0.021273324,-0.05749001,-0.03021957,0.02857993,-0.067990735,-0.070297584,0.057483613,-0.025745902,-0.0044888733,0.078025945,0.073470645,0.06618468,-0.049746517,0.035935197,0.083708785,-0.034046717,0.0043206736,-0.059464894,-6.328022e-35,0.006149227,0.018404642,-0.019171303,0.063220866,0.02030858,0.028349211,-0.07275251,0.036924757,-0.14421956,-0.03774401,-0.060874145,-0.047035195,0.024851657,0.004117105,-0.021428114,-0.053746846,0.03858472,0.041661497,-0.072127156,-0.0016247384,0.081960686,0.0049231993,-0.0017178631,0.026797177,0.012187901,-0.036156006,0.0074144676,0.010153114,0.053228024,-0.023708254,-0.018525988,-0.07636835,-0.09396894,0.059575763,0.03837478,-0.018518496,0.009045562,-0.0497073,0.039081402,0.17004877,0.0038292476,-0.00956876,0.046748746,-0.06588852,0.06792421,0.037024997,0.014463787,-0.018099204,-0.045960035,0.019810528,0.04913735,-0.016550459,0.0679611,-0.012154189,0.035733573,0.019140765,-0.10231003,-0.012476996,0.02170569,0.04412256,-0.0027989927,0.008839251,-0.03543959,0.011450544,-0.06660938,0.026506543,-0.03348423,-0.063207515,0.045095615,0.07368908,-0.027611585,-0.010457303,0.04465474,0.030781295,0.027886173,0.01193954,-0.16477956,-0.0027435694,0.013591184,0.045868848,-0.08824249,0.054934993,0.0030896335,0.023893215,0.04415977,-0.013567432,-0.05304014,-0.014076063,-0.0028384277,0.044634007,-0.038504142,-0.080916844,-0.055883013,0.012022732,0.077688895,-2.4456726e-33,0.05938837,-0.0507697,0.0036407958,-0.091618046,-0.1240591,0.045566924,0.015492668,-0.049763054,-0.0052729947,0.00025345522,0.04489981,-0.00018284799,0.09542971,-0.057445887,0.022726469,-0.0048165456,-0.030981341,0.036202107,0.018637557,-0.018069768,0.01870534,-0.034924798,-0.03730836,0.035252135,0.063004985,-0.007299442,-0.015609249,0.071382254,0.03679177,-0.027222332,-0.05733445,-0.033493046,0.033975493,0.062706605,-0.010885855,0.09660463,0.005462907,0.017466689,0.03748942,0.026481144,-0.0075677494,0.071945265,0.010040686,0.07068223,0.009758364,0.066118374,-0.0220804,0.0452944,0.039846264,-0.07860097,0.026380278,-0.028748106,0.012586968,0.014133765,-0.03602624,-0.025016403,-0.014275255,0.02449359,0.0647881,-0.0011599245,-0.015890002,-0.06429743,0.08793776,-0.005445242,0.037641194,-0.0110480115,-0.011452796,0.02247416,-0.016644303,-0.09283633,0.056020062,0.0052519212,0.0008934222,0.019160816,0.035647076,-0.04304776,-0.05129237,-0.058856178,-0.027546665,-0.10264359,-0.020754466,-0.026725467,-0.0062843314,-0.057437673,0.053123143,-0.016994448,0.109103434,0.08746957,-0.04826643,0.04351873,0.025611548,0.045845956,-0.02964332,0.070770346,-0.007714418,-4.1902116e-08,0.03172501,-0.03973239,0.028404592,-0.051583607,0.0549047,0.07295798,0.0005452948,0.058733705,0.08151983,-0.0177139,-0.027904453,0.034202583,0.016390517,0.04458377,0.09281844,-0.0435625,-0.020726908,-0.0056401263,0.012352943,0.03257067,-0.08550023,0.05444799,-0.14080271,0.011486074,-0.080656305,-0.0040586726,0.018676687,0.04526246,0.027560871,-0.059432,-0.034191847,0.06347904,0.028786343,0.0019664615,-0.09644503,0.0029138713,0.09110021,-0.032867294,-0.040799443,0.011279617,0.028874032,-0.034027636,-0.0515392,-0.01657027,-0.049202196,-0.04708775,-0.0060705426,0.025341714,-0.04135746,-0.0067658294,0.07970893,-0.016292892,0.0297568,-0.052128263,-0.008562653,-0.035276607,-0.053975984,-0.08050838,-0.026768396,0.03220229,0.0057316427,-0.083283134,0.1833976,-0.014727908 +2.7.7.7,"Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase.",384,1.0,-0.06546278,-0.030251859,-0.014168728,-0.0579317,0.046368133,-0.015254334,-0.14405462,0.0349573,-0.013282802,0.02633577,0.04386127,0.036653403,-0.08154305,-0.010465268,0.025475236,0.048635986,-0.18504901,0.04089825,0.051236957,-0.060305472,0.105598606,0.007588246,-0.005478835,0.003304029,-0.038909666,0.048887122,0.06613108,-0.015701655,0.007711926,-0.057341576,0.026130555,-0.058535904,-0.03132547,-0.015834896,0.079988554,0.044606905,-0.035242278,0.0065253754,-0.019643003,0.07946701,0.09445471,0.009838942,-0.028931843,-0.008585932,-0.052865177,-0.04824282,-0.047650076,0.032003395,-0.059892453,-0.020603715,-0.054961868,-0.034294266,-0.04306188,-0.038436122,-0.008512486,0.059393097,-0.0037515936,-0.030526685,-0.0072070817,0.0020181832,0.03784754,-0.05029491,-0.046879712,-0.03979564,0.12214717,-0.032057557,0.10972334,0.0033894582,-0.019726815,0.026168073,0.012227774,-0.057215437,-0.04598067,0.0709397,0.052556396,-0.02415332,0.011524428,-0.013669139,0.047941893,0.023862585,-0.07233747,-0.026438229,0.01262275,0.021548662,0.0077350903,0.03108307,-0.004020713,0.033134274,-0.042375553,0.0812586,-0.04407126,-0.0758955,-0.024356369,-0.05509273,0.014438004,0.090669274,0.04851692,0.050749958,0.08276412,-0.064171575,0.060003247,0.04442624,-0.0904959,-0.07823758,-0.011225387,0.038434383,-0.020583458,0.030863836,0.05280018,0.009304823,-0.009898162,-0.0007590159,0.06670259,-0.061960846,-0.0868037,0.02442103,-0.029133528,-0.03959979,0.05585061,0.028054861,0.07773476,-0.030275462,-0.026424702,0.062758476,-0.042291436,-0.016000036,-0.06805827,-1.1611331e-33,-0.030618552,0.05059758,0.024624163,0.03721759,-0.00499171,0.015645875,-0.08420599,0.031460382,-0.1684939,0.034491647,-0.014839075,-0.07614106,0.03021945,0.015559478,-0.023861935,-0.021833034,0.046471678,0.07002735,-0.05791091,-0.009380245,0.045114163,-0.017411131,0.0067435177,-0.03634098,0.02849336,0.033563305,0.0052154358,-0.018479973,0.059917897,-0.015568316,0.009094975,-0.08327286,-0.05321861,0.09658798,0.045573875,-0.010070765,0.010954365,-0.08377074,0.008810518,0.08377251,-0.015197874,0.0042278185,0.020393584,-0.031438027,0.037291963,0.009438661,0.031963494,-0.0371979,-0.11008151,0.018067352,0.06540666,0.00960302,0.056389306,-0.01627839,0.041295364,0.012215261,-0.08879768,-0.030101825,0.0359348,0.056751475,-0.016658751,0.020430885,-0.08449174,0.020393359,-0.011393907,0.0053219604,-0.03702919,0.0136683015,0.065596975,0.10146203,-0.035861228,0.006112815,0.013988383,0.039048485,0.052313462,0.0010898621,-0.1097765,-0.04447824,0.041397147,0.06817792,-0.07730204,0.013292169,-0.0048301048,0.033724774,-0.010880422,0.0013680048,-0.06732579,-0.013016368,-0.02342583,0.038677603,0.0029924703,-0.073821135,-0.021425737,0.051167335,0.115665145,-2.1148135e-33,0.0632211,-0.06235341,-0.004711604,-0.07545404,-0.06293494,-0.029868169,0.013195569,-0.07726247,0.0021846786,-0.05504771,0.040909227,-0.014698334,0.077572696,-0.04578606,0.00045540158,0.046253935,-0.0410148,0.021100733,-0.0009434996,-0.0068331086,0.044929616,-0.009448131,-0.054604154,0.07780157,0.040561285,0.012697041,-0.044566773,0.09648975,0.08543964,0.0067347055,-0.038961988,-0.037283458,0.046837673,0.0037395281,-0.02152913,0.1117091,-0.0107619995,0.021472903,0.032988843,0.014505567,-0.009331347,0.059818756,0.025040172,0.033700846,-0.007577511,0.05708048,0.011273705,0.06691039,0.047443874,-0.034940846,0.0200719,0.0016808201,-0.025202641,-0.042525835,-0.007477213,-0.031112796,-0.0019648543,-0.022554355,0.06257219,-0.011736701,-0.042234384,-0.028580459,0.07394563,0.023203388,0.035697833,-0.020190902,-0.042346403,0.016025493,-0.00029286294,-0.071733385,0.054693665,0.08938164,-0.0030322014,0.016867502,0.005975234,-0.0070702666,-0.10883581,-0.046509568,-0.021701997,-0.070510946,0.004581378,-0.05102442,0.005629284,-0.055465218,0.05183514,-0.045851424,0.09404362,0.06622462,-0.05365123,-0.03136589,-0.0021405283,0.012220127,0.008221352,0.13094398,-0.012132249,-3.580386e-08,-0.0050564054,-0.06376872,0.018049158,-0.076138556,0.043258745,0.06530319,0.054854143,0.04014276,0.0761898,-0.04367786,-0.03617091,0.04217935,0.00089124264,0.03533293,0.12108074,-0.050718043,-0.0027545397,-0.039329447,-0.022452503,-0.0414021,-0.09946983,0.025496043,-0.17110078,0.038471717,-0.029250333,0.017696923,0.030967528,0.056443706,0.03747213,-0.03734888,8.9632435e-05,0.05867585,-0.014943627,0.044230618,-0.03809142,0.0076216073,0.056514546,-0.03907879,-0.040435582,-0.025652241,0.039093982,0.024059765,-0.09716167,-0.008128618,-0.07894586,-0.04444965,0.016936319,-0.026323413,-0.06923202,0.016746158,0.091947205,-0.06035344,0.022349948,-0.066913225,-0.01629331,-0.003880855,-0.0077136764,-0.038198274,-0.04673545,-0.006338581,0.045748826,-0.05308095,0.19914868,-0.036094356 +2.7.7.8,"ADP, IDP, GDP, UDP and CDP can act as donors.",384,0.99999994,-0.048042778,-0.01954592,-0.03405114,-0.049076904,0.040558733,0.013168046,0.04554549,0.0015807777,0.0033143065,0.025694419,0.060561255,0.016091974,-0.066341214,0.02925327,0.002884411,-0.0056210873,0.0068421667,0.0055727973,0.027337743,0.07604809,0.04068552,-0.0681197,-0.026249774,-0.04864903,0.061821066,-0.051342715,0.06701761,-0.0724051,-0.011433744,-0.019521028,-0.031647447,-0.06630118,0.042559393,0.009622377,0.04051169,0.058022607,0.030020935,0.046039827,-0.060744096,0.016445436,0.04641289,-0.04627114,0.015771072,0.02673479,-0.025190668,-0.012188114,0.039122753,0.058541372,-0.0952123,0.007578228,0.04846416,0.09206299,-0.014303805,0.07507239,-0.0572828,-0.01283635,0.0063954135,-0.010021167,-0.02533173,-0.014720889,-0.0068150857,0.05447197,-0.009987456,-0.022109997,0.10162459,0.08972108,0.05060732,0.026187984,-0.08407795,-0.052097317,0.04845427,-0.059302434,0.0149318,0.018935991,0.061774146,0.009202378,-0.02337392,0.028333811,0.07010499,-0.04515044,0.014568489,0.1108225,-0.0432789,-0.025185369,-0.02027676,0.04358622,-0.05708961,-0.06844834,-0.015255911,0.020070003,-0.07179427,0.028191881,0.0097401375,-0.041638628,-0.059344824,0.010973631,0.034337316,0.010015528,0.0740903,-0.016865715,-0.026164116,0.11229206,-0.019991944,-0.068861276,-0.03823014,-0.036307734,-0.03738412,-0.046087347,0.08466834,0.10142927,-0.07765192,0.027249208,0.0153797325,-0.040669076,0.05652762,-0.0515117,-0.1576075,0.014151425,-0.036985494,-0.0703364,0.013911206,0.0008178948,-0.016820827,0.014632203,0.044921696,0.015085183,-0.054126024,-1.8413834e-33,-0.04344,-0.018901918,0.036977414,0.018940447,-0.066008046,0.022880558,-0.017392108,-0.033224158,-0.09109701,0.059088077,-0.060132015,0.01808979,0.07451938,0.07908054,-0.020889211,0.06498522,-0.048196964,0.008987977,0.0795003,0.04754939,0.08420191,0.060551614,0.029492531,0.005760715,0.1628588,-0.04670135,-0.13032098,0.01797131,0.12839507,-0.010437236,0.030272104,0.0035169977,-0.018921334,-0.013156309,-0.016640436,0.010969925,0.01683283,-0.03209867,-0.043565698,-0.058170855,0.023651237,0.014444085,0.030949168,0.037261646,0.03391833,0.0552636,0.042951934,-0.0608972,-0.08296043,0.040867742,0.020555772,-0.03036467,-0.05834021,-0.07091799,0.011158352,-0.0645168,-0.04282442,-0.026386043,-0.0051122694,0.023146417,-0.0026034857,0.013993823,-0.00996952,-0.008391706,-0.12086122,0.046838883,0.05609729,-0.0472793,0.05377377,0.0074010957,-0.007007282,0.026768915,-0.030851351,0.061674036,-0.08861028,-0.012615439,0.032887004,0.0063954275,0.03368161,0.06927414,-0.13747692,-0.057150166,0.057551935,0.04649508,0.05779454,0.010838416,-0.03266505,-0.053985476,0.035301145,-0.03592523,-0.072694354,0.029371334,-0.09750076,-0.028141778,0.033862416,-1.3951962e-33,-0.042655658,-0.05857356,-0.021700341,-0.0452692,-0.0028851172,-0.02381232,-0.01827962,-0.0499873,0.06781443,-0.018594569,-0.029998891,-0.11231025,0.06670859,0.0593572,0.04506805,-0.017521445,-0.054827288,0.00083538255,0.013450163,0.0122732045,-0.015209592,0.11253815,0.0316378,0.04960733,0.058965884,0.0022398785,-0.11161464,0.01351027,0.11966859,-0.06513065,0.07201459,0.011197345,-0.104039714,-0.028194278,-0.08786908,0.08130488,0.03125305,-0.026137553,-0.033218052,-0.059375223,-0.0019531576,-0.022724891,-0.041534897,0.062185638,-0.0441667,-0.0066076224,0.059891034,0.018550595,0.020561576,-0.06693461,0.016651068,-0.011486362,0.008095612,0.017807243,-0.005400876,0.08592702,0.095317625,-0.00095936813,0.07231294,-0.06938787,0.02368204,-0.013283375,-0.015182662,0.09858704,-0.04354339,-0.034997057,0.12333988,-0.03217311,0.012029396,-0.023558576,0.08061059,-0.06293153,-0.050908037,-0.020199671,-0.025453076,0.021115515,-0.085261725,0.09976578,0.016889013,-0.027898327,0.014137207,0.0055184043,0.038614694,0.024232926,0.041235153,-0.014122583,0.09433962,-0.118495345,-0.01574544,0.03635303,-0.1283445,-0.021237627,-0.013214461,0.068099,-0.035845578,-2.1966557e-08,0.021709025,0.1294115,0.008942961,-0.027140101,-0.003203677,-0.045031138,-0.041051693,0.044394664,-0.039999496,0.056313146,0.005435047,0.07902275,-0.0738382,0.0067763296,0.041052442,-0.041086867,0.008428858,-0.027743427,-0.03710336,-0.04966432,-0.060220663,0.036722727,-0.073381945,0.005472538,0.0073047616,0.027591836,0.036681682,-0.033030838,0.038159613,0.007468249,-0.008217289,-0.013491762,-0.08183125,0.025368337,0.039485577,0.03296839,0.019020077,-0.07003971,-0.038637985,-0.012247716,-0.012230865,-0.04306378,-0.04165767,0.013010174,0.0043419576,0.010803359,-0.03150415,-0.06414325,0.04978354,-0.041336525,-0.050948188,-0.05302227,-0.01332176,-0.04105071,0.053692937,-0.056546662,-0.028422175,0.06847727,0.0737287,-0.004042931,-0.016553603,0.029648406,0.07371447,-0.049324226 +2.7.7.10,"alpha-D-Glucose 1-phosphate can also act as acceptor, but more slowly.",384,1.0,-0.07683442,-0.08184514,-0.051484678,0.01635649,0.035892155,-0.07625929,0.06133703,-0.018148333,0.057598867,0.087580204,0.014385619,0.10864574,-0.106608674,0.0821138,0.009624195,-0.012193356,-0.010370641,0.006527174,0.0013444526,0.05149484,0.028795147,0.026148189,0.017051358,-0.024823727,0.020264784,-0.015226126,0.032941043,-0.030937435,0.009920897,-0.07185538,-0.07311645,-0.048959903,0.053803887,0.06580145,-0.048796427,0.12997483,-0.030278234,0.002905869,-0.07401002,-0.009421103,0.061557036,-0.05973969,0.050982334,0.041573774,-0.06891524,-0.05552855,-0.07426674,0.028072191,0.014109326,-0.065717384,-0.065644495,-0.0062999465,-0.050085094,0.010065233,-0.013360141,0.0820896,-0.071567275,0.038610898,-0.043956388,-0.048495643,-0.06631889,-0.038302965,0.012474315,0.02152088,0.094380386,-0.056796834,0.042639352,-0.08130532,-0.0750768,0.0019230755,0.0009459416,0.007533275,0.003295979,-0.022319684,0.036297012,0.0009739655,-0.09336612,0.0024450773,0.07171224,0.045358766,0.034803357,-0.0106318,0.055399325,0.055833086,-0.037548456,0.0012014274,-0.012541962,0.058744136,-0.035549194,0.012848679,-0.005025274,0.012549609,0.04110641,-0.009732251,0.020415695,-0.023377283,0.039629575,-0.050986025,0.01955803,-0.038427778,-0.055366147,0.11993274,-0.045621138,0.02897269,-0.07127815,-7.356558e-05,-0.00082337996,0.009935363,-0.04000738,0.056253675,-0.022543825,-0.04402405,0.0988043,0.08156665,-0.11284223,0.056271244,-0.017066028,-0.042894475,0.012527059,-0.018003426,-0.07034523,-0.03426357,0.002093604,-0.027560778,-0.018251333,0.09607784,0.007256434,-3.5715655e-33,0.028426893,-0.046546154,-0.021986255,-0.03824816,-0.10727459,0.046774853,-0.059726976,-0.018244935,-0.011436807,-0.038706087,-0.065512255,-0.058829598,0.0406459,0.07664123,-0.044617295,-0.026282568,0.0005419841,0.0812585,0.05079549,-0.049995985,0.04613224,0.054933142,-0.04313957,-0.018376915,-0.0006527407,0.00056032924,-0.09573881,0.066724926,0.02104056,-0.029387273,0.07110447,0.007540791,-0.07249885,0.04849399,0.0024905384,0.0119986115,0.003919429,0.028071761,0.03319691,-0.045550056,-0.047502108,0.011249012,-0.028609361,-0.009052744,0.014694561,-0.03268436,-0.0073966384,-0.04564821,-0.020577101,0.10092358,0.009597453,-0.0055097616,-0.06156727,-0.03845076,0.014423311,-0.02840636,0.031134877,-0.011951914,-0.055823017,0.027344204,-0.010206005,0.055207554,-0.011077938,0.028391879,-0.032778952,-0.0025446846,-0.04914913,-0.05818018,-0.03762774,0.06546771,0.019488867,-0.04197218,0.01566345,-0.04576783,0.0131250685,-0.06311848,0.04112199,-0.011096982,-0.021966904,-0.037139352,0.0037758613,-0.08132453,-0.02656206,0.019352386,-0.11061579,0.027536025,0.016630452,-0.11579665,0.007827507,-0.031571012,0.020315366,-0.013414172,-0.10753418,0.0064446377,0.08919259,3.464292e-34,0.073783375,-0.099940345,0.09067981,0.02982892,0.011007741,0.094526954,0.053666566,-0.052746132,0.12247676,0.002376861,0.060659185,0.09934603,-0.027696185,-0.014734767,0.022997586,0.028478766,-0.026190663,0.061686963,-0.010630259,0.012044587,-0.030397205,0.12057072,-0.0046012243,0.05455318,0.04277814,0.010984456,0.01855041,0.024135834,-0.015131187,0.022508765,-0.0044825333,0.01124845,-0.029983368,-0.024190068,-0.02857729,0.008156898,-0.0662001,-0.022113414,-0.08988699,-0.0034899076,0.014499122,0.04858282,0.039332826,0.005037218,0.06210257,-0.022559186,0.07427023,0.018845204,-0.026033806,0.0023021735,-0.021929998,0.08456403,0.009682415,0.021260576,0.09361901,0.089485325,0.024741966,-0.026850894,-0.07460886,-0.019762518,0.0073934584,-0.052638028,0.06449445,-0.028967708,0.035042778,-0.03939704,0.04257534,0.04196299,0.12279768,0.061091516,0.09414794,-0.0018793156,0.058808982,0.083980784,0.050384406,-0.0283056,-0.05198013,-0.03730001,-0.0039105285,-0.06551792,-0.08522246,0.15330464,-0.020446617,-0.07950509,0.023273416,-0.07399364,0.004118777,-0.049628295,-0.033312015,0.10591983,-0.0042590336,0.0021421653,0.047161374,0.012652164,0.050850373,-2.3347528e-08,0.07086572,-0.043909363,0.04316961,-0.024856165,0.0038613833,0.01022016,0.016951708,0.013133265,0.04476395,-0.021111157,-0.04169834,0.15746823,0.08071893,-0.013356302,0.0892059,0.009369496,-0.061347224,-0.056527425,-0.07920327,0.007520181,-0.09275424,-0.020557739,-0.08632159,-0.05961881,-0.027975464,-0.033786826,-0.0048236493,0.020397425,-0.045556147,-0.0115559995,0.007866587,0.0057199164,0.0793922,-0.05454858,0.008838722,0.05301986,0.06356835,-0.01790332,-0.045857668,0.020367127,0.027194064,-0.0751442,-0.010499572,0.015601162,-0.089872725,0.06411827,-0.042421117,-0.035733517,-0.051275473,0.0011116042,0.02561452,0.017214878,-0.08178699,-0.065347046,-0.04088181,0.016444806,-0.0693638,0.0041658417,0.045956686,-0.037353724,0.03429946,0.0101052625,0.101838894,-0.052079476 +2.7.7.13,The bacterial enzyme can also use ITP and dGTP as donors.,384,0.99999994,-0.13583544,-0.012707188,-0.0057963966,-0.07684884,0.0345731,0.008321175,-0.0013919487,0.13856472,-0.03315216,0.004232656,0.02100721,-0.027283395,-0.09713623,0.15790217,-0.050040714,0.0027516866,0.008330509,0.0030286647,0.06464172,-0.0068781995,0.020608226,0.035206437,-0.030614946,-0.0627221,0.04749742,0.042932678,0.014793591,0.0077696354,0.01655495,-0.019735496,-0.04543557,-0.01615855,0.000962313,-0.061776135,0.03640666,0.09201507,-0.013592762,-0.02359398,0.058335178,-0.030106787,0.05595598,0.0281572,0.027535334,0.00041180337,-0.022754917,0.048702873,0.0036021946,0.08083595,-0.01176837,-0.06587052,0.0125865,0.041195568,0.025310226,0.012056521,-0.00940714,-0.013442752,-0.01474616,-0.056341253,-0.08544433,-0.057600796,-0.022096392,0.009300768,0.030603671,0.008976248,0.07099166,-0.02843378,0.04736025,0.011939859,0.033785988,-0.017566176,-0.07289274,-0.047466256,0.0043143006,0.12221194,0.04940149,0.04955887,0.049322613,-0.048387747,0.056403782,0.00016634182,-0.040656753,0.03438885,0.037732486,0.07865624,0.009483911,0.016962131,-0.010035462,0.031264246,-0.024923706,0.026205378,0.02355747,0.009618646,-0.0074247853,-0.07045576,-0.08608592,-0.0024085448,-0.052023504,0.020375695,0.004208077,-0.06740508,-0.04092843,0.0067927786,-0.040052086,-0.06898779,-0.07614803,-0.067819305,-0.017866477,-0.0030120916,0.102681495,0.0015271001,0.022478491,0.06176152,0.040629633,0.0074189864,-0.0027282038,0.06922137,-0.068284474,-0.07995447,-0.051689725,0.027601762,-0.035561148,-0.11980126,0.024489664,0.06885399,-0.08114585,0.005559518,-0.055712055,-1.7377989e-33,0.01927321,0.006846663,0.012491957,-0.033415806,-0.020741757,0.017553193,-0.044901133,0.0041345586,-0.059485827,-0.05489366,-0.13383844,-0.1063725,0.03730093,0.023325609,-0.058399193,0.0072425962,-0.046984877,0.02211883,0.031517122,0.019248202,0.07253504,0.020327631,0.027904902,0.0242989,0.1492759,0.01138958,-0.02976908,0.02916339,0.060565177,-0.01930115,0.014370197,-0.084116444,-0.063962586,0.021435378,0.005819468,0.03493587,0.0062076706,-0.058487173,-0.026088629,0.032668956,0.06603981,0.065421425,0.048751608,0.059864186,0.055147216,0.014143105,-0.058208916,0.0027985824,-0.07690104,0.0059312405,0.06087477,0.0016779745,0.043618504,-0.12145276,-0.022851251,0.055082817,-0.018959075,0.01390558,0.04706565,0.032476183,0.0027260662,0.09050112,-0.045411404,0.04292322,-0.006812862,0.046474375,0.03138377,-0.0946641,-0.0030384306,0.07372841,-0.10452754,-0.02505427,-0.008921909,-0.003117068,-0.05087772,-0.055414494,-0.03048866,0.04803325,0.123201,-0.00023736936,-0.03205343,-0.081766866,-0.0052363593,-0.027344083,-0.03009697,-0.018685091,-0.027604748,-0.033536643,0.00069961214,-0.027264427,0.109450445,-0.05745809,-0.042059418,-0.013275733,0.008366655,-9.368606e-34,0.042038426,-0.099582784,-0.010179954,0.009009409,-0.0011523424,0.08395703,0.035459675,-0.08199294,0.13169748,0.043662302,0.058591176,-0.028661152,0.0008336154,-0.036537938,0.037436273,0.011963803,-0.047777984,0.02643562,-0.07783187,-0.009868253,-0.027891213,0.07173921,0.04548152,-0.029577937,-0.022831054,0.035140082,-0.07235352,0.07262311,0.05750928,-0.014864499,0.071648516,0.037463214,-0.13354474,-0.10898383,-0.02508426,0.02582707,-0.021583399,-0.01640048,0.0013982636,-0.043612685,0.051117904,0.025714327,-0.0049783015,0.089140676,-0.062432453,0.067092046,-0.009865178,0.021059847,0.0723132,-0.024130927,0.020120533,-0.02423983,-0.0038392618,-0.0018681224,-0.0107087325,0.018985689,0.10346459,0.003908466,-0.03703312,-0.041447863,-0.062229533,-0.07544486,0.07217687,0.040230043,-0.00936426,0.040461365,0.057650696,0.009770149,-0.001046552,-0.018094296,0.03993426,0.010918613,0.016160343,-0.008327146,-0.06620384,0.028254382,-0.071651384,0.019660732,0.07822651,-0.013750142,-0.046118457,-0.021903388,0.012213509,0.021235744,0.06672106,-0.10822145,0.07227585,0.06361133,-0.0034554878,0.05051373,-0.072474845,-0.0055079963,0.02902019,-0.021075342,0.059722427,-2.1386654e-08,0.059292395,-0.038873106,0.02755202,-0.02398873,-0.041619502,-6.1231396e-05,-0.05166516,0.058894727,0.09284725,-0.007918628,-0.023197427,0.09557324,-0.053716272,-0.008906447,0.06679336,-0.042557996,-0.04112304,-0.03219185,-0.06156364,-0.07378227,-0.09939719,-0.041002117,-0.034966715,0.034141045,0.023783341,0.005840482,0.025401028,-0.007219325,0.054187838,-0.047215052,-0.044312496,-0.0051654894,-0.08818287,0.031606548,-0.030980527,-0.0028881198,-0.020215547,-0.05052748,0.009108361,0.05915851,0.036993027,-0.053180538,-0.118853904,0.033107176,-0.019825095,0.05195285,0.023278521,0.017045533,-0.081616774,-0.0247614,0.031374127,-0.055604942,-0.0068872287,-0.015503671,-0.08910382,0.050734878,0.030472271,-0.06350914,0.044967916,-0.011845052,-0.04256041,-0.0054712845,0.16188686,-0.015243967 +2.7.7.19,"Also acts slowly with CTP. Catalyses template-independent extension of the 3'- end of an RNA strand by one nucleotide at a time. Cannot initiate a chain de novo. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. See also EC 2.7.7.6 DNA-directed RNA polymerase.",384,0.99999994,-0.070150815,-0.055554096,-0.011937377,-0.048175994,0.07743227,-0.0021335331,-0.12706734,0.024615599,0.017157769,0.019922582,0.06466869,0.062304374,-0.08462955,0.014898031,-0.0031888704,0.051504098,-0.1568633,-0.011854013,0.059671566,-0.034671593,0.045801457,0.026294623,-0.029946778,-0.016106134,0.0075022704,0.027706552,0.096715406,-0.029380335,0.015578119,-0.04775481,-0.025467323,-0.04057571,-0.028599948,-0.015361501,0.039626565,0.09504978,-0.054185364,-0.021861555,-0.0044357367,0.07248808,0.1206136,0.040915534,-0.04036559,-0.008432841,-0.016661264,-0.050999038,-0.04753623,0.045302972,-0.06310355,-0.019170577,-0.03407898,-0.034375135,-0.038197853,-0.015769659,-0.05148163,0.062704034,-0.020228764,-0.02113361,-0.021838373,-0.017217204,0.01198689,-0.018304909,-0.021170747,-0.011014446,0.1618754,-0.009290647,0.13106579,0.021378808,-0.01834297,0.03546287,-0.031512856,-0.011244136,-0.04588791,0.08254261,0.035315264,-0.057811026,0.023228042,-0.016955975,0.051009595,0.009835406,-0.058704223,0.00691358,0.023247626,-0.004585818,0.027358932,0.050238166,-0.019045021,0.043380614,-0.01623603,0.050699722,-0.04808834,-0.021881845,-0.02671212,-0.01835851,0.018057546,0.0540468,0.05897964,0.026950354,0.04428534,-0.062681966,0.053442962,0.08055344,-0.065031536,-0.025349423,-0.027926428,0.023142723,-0.0022775072,-0.008082248,0.011819201,0.059552185,0.010834456,0.0005912634,0.097642876,-0.07612558,-0.037695818,0.02931016,-0.058447424,-0.059614193,0.06931257,0.0057773907,0.052517153,-0.051325087,-0.033113685,0.0655453,-0.043597724,0.024558876,-0.053239223,-5.9041027e-34,0.007751478,0.015548227,-0.00903616,-0.00079867843,0.045328826,0.0007059404,-0.06319845,-0.0018469401,-0.18811476,0.037780665,-0.046215866,-0.079947226,0.0026640457,0.019549362,-0.014312141,-0.02916413,0.031091876,0.100437485,-0.05464487,-0.026496131,0.018306823,0.018638602,-0.016697163,-0.01195579,0.023819469,0.039283592,-0.05861654,-0.0021490047,0.013380468,-0.007839308,0.009950797,-0.048938036,-0.11048196,0.108592205,0.057206966,-0.010448488,-0.014580693,-0.08560181,0.035217643,0.09558745,-0.011683044,0.0015477443,0.03066717,-0.011525775,0.0066466336,-0.010240071,-0.014225964,-0.035120238,-0.103815995,0.02194828,0.106215574,0.000191044,0.03425749,-0.044618763,0.03300707,-0.023048894,-0.08933221,-0.019152353,0.042314578,0.075932816,0.012160252,0.02046923,-0.07444685,0.07961445,-0.041864023,0.032323692,-0.03654308,-0.04246449,0.10155105,0.1081265,-0.02524599,0.01334552,0.03414429,-0.0030702827,0.059413392,-0.0062443833,-0.061572168,-0.0355669,0.019101726,0.10919415,-0.078752816,-0.02778989,-0.030713284,-0.014176888,-0.019552894,-0.019552633,0.003149184,-0.018493716,-0.004451136,0.04538612,0.029900199,-0.023978328,-0.04060374,0.029009754,0.11757927,-2.0420647e-33,0.09271761,-0.07160334,0.03225262,-0.06547899,-0.09775746,0.0019216094,0.0031578343,-0.07791031,0.012580114,-0.043475736,0.049898237,0.020094061,0.03629184,-0.01611475,0.027116247,0.037433296,-0.011040585,0.0415525,-0.014702668,-0.0037052734,0.04621048,0.00029998636,-0.053206183,0.081682086,0.031108428,0.0073636,-0.040630523,0.084300555,0.038230017,-0.012203323,-0.02993553,0.0092872875,-0.015221391,0.010553384,-0.040777497,0.13299112,-0.034732454,0.015343794,0.037629083,0.010632561,0.031234635,0.057869885,-0.011331435,0.054112233,-0.046914894,0.05575322,0.008800594,0.032899793,0.039714333,-0.01732117,0.035315953,0.046101566,0.013661866,0.0021393464,0.0054406486,0.0050394633,-0.024210352,-0.023497548,0.008880449,-0.04121342,-0.04080927,-0.006082032,0.031837285,0.024797097,0.06563915,-0.019074515,0.0014174371,0.002399412,0.035955127,-0.052577954,0.023261799,0.06922173,0.007172538,0.0043594707,-0.016316552,-0.030893346,-0.09211823,-0.032447483,-0.03240081,-0.079239205,-0.016294478,-0.046145532,0.04371696,-0.07071067,-0.05656648,-0.05323161,0.04432371,0.09637436,-0.013709582,0.012378502,0.032792885,0.018198974,-0.019164037,0.093077585,0.00437072,-4.0367556e-08,-0.017440975,-0.033588197,0.009461518,-0.087793075,0.027845517,0.045163564,0.040978987,0.031078862,0.08087497,-0.010233577,-0.015762325,0.04011696,0.0020372458,-0.023196517,0.11317468,-0.015121002,-0.04750151,-0.0535879,-0.021983191,-0.06991752,-0.10998696,0.048514474,-0.13601947,0.051650923,-0.09401938,0.027702274,0.013625969,0.062308896,0.023314126,-0.04820259,-0.031852666,0.070846,-0.029080134,0.016058348,-0.05924046,0.0049545094,0.093199424,-0.046853654,-0.030211255,0.011137917,0.020690843,-0.013365249,-0.113386735,-0.030859986,-0.09687411,-0.02508649,0.031994674,-0.057534836,-0.03148656,-0.014996534,0.06627818,-0.010941949,-0.0063471724,-0.040784545,-0.018170113,-0.011678535,-0.018427236,-0.063734986,-0.063168235,-0.0042357394,-0.014346252,-0.061224535,0.22866838,-0.07490008 +2.7.7.21,May be identical with EC 2.7.7.25 tRNA adenylyltransferase.,384,0.99999994,-0.08185756,-0.012373342,-0.050149664,-0.012558159,-0.040921245,-0.085165404,-0.04850293,0.02211171,0.028602881,-0.017767621,0.09189165,-0.0791173,-0.091044344,0.0127302455,-0.044864252,-0.0062167645,-0.085893594,-0.06116843,0.030319255,-0.04027056,-0.023816416,0.1141784,-0.0026016007,0.08390697,0.018357294,0.004595866,0.030485157,0.05607276,0.016535511,-0.085264936,-0.014233714,-0.039401677,0.013229015,-0.026296228,0.041794106,0.027699843,-0.07870977,-0.038388904,0.043228965,0.011218989,0.09035262,-0.047491547,0.031155156,0.020028953,-0.066851,-0.031328328,-0.0046150796,0.038669195,0.0026635951,0.041709658,0.053197797,-0.09182599,-0.08211098,-0.033310752,0.06694533,0.035326067,-0.103242196,-0.04371372,-0.00053724216,0.027244022,0.038126394,0.018115776,0.0003366269,-0.013962266,0.039996773,-0.054569207,0.10172512,-0.11313439,0.04067944,-0.058988046,-0.0566415,-0.05419959,0.048496384,0.10916654,-0.016830832,0.045030594,0.012595204,-0.023279648,-0.031396173,-0.025268303,0.0073449314,-0.049333844,-0.014440161,-0.036804345,0.0019422843,-0.04164565,0.02527753,0.02704884,-0.036729,0.03282476,0.062692136,0.0363428,0.09751296,-0.0051447307,-0.04622876,0.061223846,0.04469328,0.112319544,0.031127015,-0.018886477,-0.03735221,0.09115975,-0.07011294,-0.017125133,-0.018952454,-0.047602117,0.013892504,0.015225817,-0.023776338,-0.02851759,0.033580527,0.002387099,0.061107215,0.022761576,0.020193573,0.07202611,-0.024943486,0.030188603,0.102740936,0.051947787,-0.020697957,-0.033079155,0.07206985,0.07844489,-0.035805963,0.017564734,-0.06314079,6.751238e-34,0.014893015,-0.0025918405,0.07190855,0.036346156,0.007739552,-0.027771415,-0.113877445,0.015106275,-0.07210338,-0.071467504,-0.12446342,-0.08389856,0.050399035,-0.05319099,-0.0111522665,-0.03582037,-0.08069936,0.024840074,-0.019711675,0.009734346,0.039959896,0.02641029,-0.016363153,0.016649038,0.073280804,0.019566571,-0.025143808,0.028931927,0.08240169,-0.011575251,-0.05180847,-0.043644764,0.0054979464,0.0029394801,0.009378117,-0.032092135,-0.0037262724,-0.035412528,-0.038011488,0.08663049,0.011911823,0.039718397,0.03547848,-0.086404614,0.03674635,-0.0041860067,-0.009818711,0.03990522,0.06297289,0.039241984,-0.02011479,-0.019540915,0.04106615,-0.019850828,0.0027611826,-0.037267357,-0.0109331785,0.005849697,0.08958778,0.061313838,0.054661985,0.10302868,-0.019714555,-0.015932294,-0.054004684,0.022606598,-0.063731,-0.06969009,-0.038661446,0.061472505,-0.005977423,0.007852652,0.14830714,-0.018237278,0.09641568,-0.059833523,-0.08156721,-0.011900088,-0.06042122,0.03250576,-0.11636128,0.008932294,0.029926376,-0.04135018,-0.050048277,-0.009506833,0.009148733,-0.036537223,0.009276458,0.09011804,-0.0022076087,0.03256279,-0.11957068,-0.00932894,0.037000734,-2.0207464e-33,0.024482543,-0.042008415,-0.016506549,-0.010490845,-0.036998294,0.054764222,0.017367225,-0.0023835492,0.00599014,-0.025846869,0.17657931,0.060178585,-0.02358924,-0.07759012,0.10973039,-0.037373018,-0.034976546,-0.008665934,-0.025588913,0.016838634,0.04557198,-0.0010630178,-0.04415645,0.0529985,0.07388346,-0.019886533,0.019013355,0.053673618,0.058169175,-0.014146048,-0.09249403,0.011823785,-0.046509624,0.06573055,-0.09295858,-0.002400845,-0.015436609,-0.035756603,-0.017417865,0.004232846,-0.008766599,0.05465485,-0.018836869,0.058947768,-0.019634904,0.10320441,0.092964716,-0.0039034665,0.022616453,-0.06459988,0.06877108,0.0024505355,-0.0044197277,0.031850535,0.0061734905,0.0537783,-0.002408312,0.05059809,0.028616127,-0.015671771,0.010393044,-0.09102454,0.0038646676,-0.05758809,0.026392438,-0.019432943,-0.07028256,0.060536142,0.022372205,0.021381618,0.0016090627,-0.06401197,-0.05089144,-0.0066300184,0.0017638943,-0.049049016,0.0027531742,-0.01978737,0.02456644,-0.06621328,-0.020607883,0.014735989,0.015423204,-0.003843388,0.043578696,0.036843594,0.006090101,0.06813358,-0.028823333,0.09883891,-0.03450235,0.03183279,-0.08752069,-0.012039332,-0.022016944,-2.2010509e-08,0.016454631,-0.11121786,0.0052872454,-0.016058512,0.072986975,0.08161513,-0.051539965,0.06664414,0.05900328,0.029921342,-0.021256864,0.009017482,0.013810131,0.048535466,-0.010959723,0.045784544,-0.08434373,0.013347098,0.010088845,-0.026896235,-0.1123413,0.0042946367,-0.09059245,-0.0018508256,-0.051558428,0.020523297,-0.0047706706,0.1358672,-0.05336271,-0.12257502,0.05352738,-0.03675971,0.014184908,-0.027940921,-0.039386116,0.03104485,0.00475348,0.0055825217,-0.011653341,0.10113872,-0.016705558,-0.05958311,-0.050634883,0.04692153,0.0098575065,0.008019249,0.010831909,0.034191277,-0.017470585,-0.04660563,0.09642959,-0.018336408,0.010440803,-0.029940931,-0.015557682,-0.04083373,-0.046978217,-0.070289135,-0.004846899,0.023099326,0.058517285,-0.047598884,0.123946846,-0.009475095 +2.7.7.23,"Part of the pathway for acetamido sugar biosynthesis in bacteria and archaea. The enzyme from several bacteria (e.g., Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase [3,4,6]. The enzyme from plants and animals is also active toward N-acetyl-alpha-D-galactosamine 1-phosphate (cf. EC 2.7.7.83, UDP-N-acetylgalactosamine diphosphorylase) [5,7], while the bacterial enzyme shows low activity toward that substrate [4].",384,1.0,-0.030478494,-0.09182546,-0.09842597,-0.04413873,0.051996768,0.029481035,-0.053169627,-0.004412019,0.043559384,0.03834474,0.014009889,-0.039280854,-0.026614865,-0.025834072,-0.06648879,0.008767003,-0.049933456,-0.058479853,0.07650283,-0.018517826,0.11988999,0.04737921,-0.06191797,-0.025383312,0.015761673,0.030471563,0.051781494,-0.07677114,-0.076487154,-0.10284323,-0.013431798,-0.08423266,0.09509518,-0.01981935,0.06224692,0.09119588,-0.02099259,-0.062491953,0.10713963,0.0027849472,-0.0017880779,0.028129512,0.014414234,-0.07049346,-0.004143398,0.00023521778,0.053716164,-0.026562804,0.059366975,-0.032785762,-0.004444266,-0.0066858614,0.023156816,0.019492805,0.048559662,0.01913108,-0.06540156,-0.039730687,-0.0027163196,0.032028202,0.048462898,0.012915828,0.04376088,-0.04487366,-0.019720629,-0.07573623,0.07312603,-0.10370327,0.016430566,-0.026717002,-0.11888142,-0.04753505,0.030988498,0.004674866,0.045892075,-0.008026848,-0.023523793,-0.0235322,0.041227296,-0.03770428,0.0131317545,-0.055073787,-0.036932543,0.060418,0.004656529,-0.04202535,0.03708886,0.02549455,0.07560591,0.016582504,-0.003957551,-0.08036602,0.07664303,-0.036184944,-0.033869192,-0.0013253685,0.025203107,0.010051081,0.011616169,-0.027389186,-0.00973851,0.0759509,0.029897554,-0.06960968,0.0012333072,0.022499036,0.015378719,0.12819037,0.039247416,0.027331023,-0.014856482,-0.02885625,0.0046778065,0.016928425,-0.094561726,0.08618729,-0.0034735056,-0.13125926,-0.06817441,0.017275915,0.055972196,-0.031575866,0.075916976,0.08598069,-0.0062312414,0.101142876,-0.06888041,2.1474882e-33,0.08616729,0.0380665,0.0061601903,-0.058812875,0.023876168,0.011669793,-0.10804105,-0.019070895,0.061506968,-0.055059064,-0.060842384,-0.03461988,0.10904371,0.023238944,0.010496724,0.082948714,-0.051049836,-0.027108917,0.08907149,0.023424443,-0.03465659,0.01076729,-0.05560063,0.030631382,0.021710984,-0.013560764,-0.018988246,0.015604277,0.0823489,0.0039946814,0.036474925,-0.08787845,-0.082270145,0.0345437,0.08159458,-0.010171546,-0.0041743126,-0.00049430545,-0.0013680169,-0.031201499,0.014128508,0.06813474,0.049187943,-0.052334305,0.0013764801,-0.06865862,-0.031399924,0.09495537,0.026101544,0.09403399,-0.014295543,-0.07231415,0.15047501,0.0014200959,-0.02044433,0.02499151,-0.062326793,-0.036663547,0.06821342,0.08433942,-0.037851814,0.021407869,0.0023152595,0.02056292,-0.016316151,0.054718923,-0.026127538,-0.0044674566,0.042217344,0.04983259,-0.043010496,-0.06739263,0.024527298,0.028712576,-0.012719169,-0.031510003,-0.030346058,0.024107361,0.032527935,0.03969714,-0.001881058,-0.018786125,0.04095967,0.007686116,-0.016879424,-0.0008831167,-0.018969227,-0.05408113,0.024346754,0.08033004,-0.015913662,-0.031417176,-0.078971304,0.057734307,-0.0111570405,-3.381327e-33,0.11901487,-0.091277026,0.032743312,-0.07630296,-0.07550535,0.08037676,0.02670128,-0.013887755,0.0028012763,-0.024063021,0.05001618,0.03715168,0.025069876,-0.05075762,0.022666525,-0.054090604,0.02230648,0.108146824,-0.0011878435,0.055488504,0.019801406,0.05694304,-0.020143975,0.0023564855,0.045722842,0.007173819,0.0007373937,0.031856384,-0.028519612,0.0031974663,-0.018100398,0.0445506,-0.03230097,-0.055225063,-0.06634848,-0.011379222,-0.011183201,0.00047488709,-0.03235582,0.019201973,0.0070972955,0.095668316,0.008450611,0.026090011,0.043535136,0.07079884,-0.030808317,0.053501077,-0.070848584,-0.02776349,-0.020238955,-0.03789059,0.0012169657,-0.00037213412,0.033894934,0.03182319,-0.0028529281,0.10416044,0.025019726,-0.010458675,-0.0033348114,-0.044927068,-0.019068014,-0.06549663,0.040437326,-0.010156896,-0.04813174,0.060814347,-0.006823317,0.027144423,-0.026863063,-0.042510346,0.09419687,0.05226573,-0.00040213345,-0.03763679,-0.0842863,-0.07173315,0.024857782,-0.062465824,0.029264728,0.010127619,0.0071138176,-0.04819765,-0.07612759,0.005276194,0.06004788,0.08550366,-0.022313094,0.038738735,-0.077516176,-0.038587157,-0.057158004,0.0095618395,0.044722132,-4.786531e-08,0.07486677,0.024864594,0.052730106,-0.050037183,-0.025501195,0.06369424,-0.01674874,0.06316151,0.06514514,-0.07320172,-0.004387365,0.11827084,0.012982764,-0.0002316382,-0.059817914,0.01081994,-0.0030236258,0.040387556,-0.029343406,0.052570082,-0.09090577,-0.040427696,-0.10526954,0.02754442,0.021529183,-0.102409594,0.05460851,0.002673888,-0.0375207,-0.084899314,-0.03443494,0.023026899,0.03985305,-0.11752458,-0.08056902,-0.023957813,-0.026417853,-0.04911956,0.031806614,0.026984138,0.017795801,-0.00010134072,-0.09731419,-0.005713868,0.008468108,0.03986489,-0.002379093,0.060266245,-0.057769142,-0.04504203,0.0064849597,-0.04729564,-0.008918846,-0.1288511,-0.063866094,-0.046663556,-0.025527978,-0.08780022,0.03177295,0.019320505,0.06344736,0.0049558314,0.08719088,-0.010553936 +2.7.7.24,Involved in the biosynthesis of L-rhamnose in bacteria.,384,1.0,-0.032980975,-0.06775967,-0.078252114,0.019018384,0.07429462,0.123206854,-0.084005244,0.06733427,0.023242434,0.029751826,0.03484735,-0.01508081,-0.04303981,-0.0033351423,-0.05413495,0.045138188,-0.0863073,0.01113766,-0.063267715,-0.012926502,0.11133547,0.015019733,-0.075228244,0.019439444,0.06331472,-0.008590891,0.08213439,-0.033056706,0.0042825583,-0.028280426,0.04095879,-0.04610642,0.079687096,-0.13083884,0.017003622,0.09131593,0.022376109,-0.073093005,0.13994586,0.05482973,-0.038145818,-0.014324207,0.0701319,-0.06262749,-0.01730673,0.046345994,-0.05575239,0.08561464,0.03355196,-0.015332952,-0.04770367,-0.019156769,-0.0340122,0.040389434,0.011779569,0.00053783564,-0.06752908,0.00071256165,-0.020253083,-0.007135219,0.015353304,0.0076344865,0.0023551947,0.036106642,-0.09614545,-0.07285856,0.02381811,0.004417632,0.0070644896,0.01755121,-0.010762354,-0.04984181,-0.011585648,-0.006622472,0.012340024,0.048952397,0.02041565,-0.054562215,-0.09525825,0.0258606,0.058442924,0.022115821,6.956148e-06,-0.00053269527,-0.015270687,-0.034497876,0.0071849227,0.049693104,0.042246412,0.028597675,0.01680008,-0.09543175,-0.025355017,-0.06807805,-0.046446938,0.0017091737,0.045486134,0.0031035373,0.049490653,-0.08964518,-0.056871068,0.038519472,0.0020185767,-0.07296301,-0.06177295,0.01917215,-0.059149023,0.057598393,0.023528138,-0.033903465,0.08000938,0.05034675,-0.01829311,-0.038752988,-0.10914748,-0.010621093,0.019370086,-0.08932192,-0.15098397,0.024453875,0.021224434,-0.028753364,0.018655384,-0.00027740933,0.000155328,-0.041664563,-0.042437624,-3.098423e-33,0.04399651,0.0051802234,-0.072029606,-0.03170673,0.054511003,-0.008496696,-0.07562509,-0.00860285,-0.0119846715,-0.02201323,-0.025407767,-0.05789569,-0.0011219211,-0.064963445,-0.06259181,0.12711668,0.02156203,-0.048797898,-0.008402454,0.0006475109,-0.03493331,0.037898965,-0.025627464,0.0010509812,-0.015162538,0.04068927,0.09171395,-0.053963855,-0.012343589,-0.039455716,0.03192992,-0.030811813,-0.05234939,0.05245717,0.061827093,-0.0028877745,-0.070749104,-0.09954929,0.021747286,-0.007302345,0.07417842,0.06874794,-0.010669973,0.008478959,0.008449574,-0.027649686,-0.012681368,-0.031714313,0.066455804,0.11529929,0.06050019,0.04330256,0.08358022,0.024981795,-0.05718135,-0.099259876,-0.07747884,0.029052122,0.05035675,0.059903428,-0.004478371,0.026354643,0.008135948,-0.011567241,0.0038804752,-0.07495158,-0.009916936,-0.03621121,0.0076408237,0.018187016,-0.017153615,-0.11715591,0.08269607,-0.032735106,0.049508408,-0.051705126,-0.020187026,0.016720476,0.061611045,0.02390643,0.020712556,0.051307224,0.021229548,0.0047734585,0.009699954,-0.049287558,-0.035142902,0.005278733,0.020397598,0.004476358,0.003837684,-0.08758021,-0.04182105,0.03604281,-0.020638805,-9.134552e-35,0.055299122,-0.087425604,0.05142545,-0.011812026,-0.026797801,0.038918294,0.017132193,0.052674685,-0.04250407,-0.059158552,0.06058933,0.030886684,-0.04171292,0.04488297,0.062180635,-0.032097507,0.078739904,0.04289198,-0.024621367,-0.023713574,-0.004137603,0.010570879,0.047312837,0.012110527,0.039572906,-0.005305249,-0.00016659024,0.06325679,-0.004151856,0.063952446,0.0280788,0.007551058,-0.08303326,-0.068207264,0.010289333,0.06480807,0.019698394,0.08532768,0.006841156,0.05317145,0.041826997,0.041037872,0.019392252,0.021992639,0.025923936,0.006579818,-0.09824019,-0.018808354,0.014744838,-0.02873943,-0.0066657504,0.033721082,-0.013238664,0.0030025858,0.01647494,0.004914952,-0.06794337,0.04235678,0.0646822,-0.041332547,-0.0994338,-0.09884272,-0.040003847,-0.0053671445,-0.0052518602,0.10244287,0.00096233236,0.033525795,0.07452936,-0.002134925,0.071510926,0.07814787,0.08142368,0.030510519,-0.04706318,-0.0609619,-0.07570746,-0.15479146,-0.010128068,0.03714542,0.042397678,-0.03775513,0.017094614,-0.0058851065,-0.018641343,-0.063492544,0.042943805,0.04883794,-0.03884806,-0.057965744,0.06589805,-0.036059804,-0.019196294,0.03934568,0.11764491,-1.9999497e-08,0.022675958,-0.088497624,0.049310002,-0.00892438,0.050996527,-0.014526654,-0.035040677,0.023654714,-0.025270578,0.050995372,0.008029251,0.021675983,-0.033011235,-0.00441736,0.07395839,0.032329213,-0.06983329,0.08180068,-0.011043516,0.08103679,-0.020009916,-0.0011865007,-0.07014851,0.0056393263,0.042788897,-0.008798467,0.0566828,-0.010716078,-0.010193577,-0.040509112,0.08380757,0.008417802,0.029680824,0.08904263,-0.11017253,-0.12098401,-0.020875053,0.013656842,-0.022424614,-0.07980032,-0.004523085,0.028834779,-0.04657946,0.06905744,-0.022921087,0.020641621,-0.033345938,0.044375025,-0.021606198,-0.038538113,0.07056563,-0.064865135,0.008569756,-0.076844044,-0.06998543,-0.07256831,0.035806928,0.009933778,0.0103400815,-0.046679065,-0.03928746,0.05502789,0.13583606,-0.018856207 +2.7.7.25,May be identical with EC 2.7.7.21 tRNA cytidylyltransferase.,384,1.0,-0.09937481,-0.008322037,-0.056085806,-0.007616005,-0.015843688,-0.0656716,-0.029809164,0.022696862,-0.00035392374,-0.036968313,0.11294115,-0.059730448,-0.024385277,0.0035905144,-0.05574399,-0.021210676,-0.07460573,-0.03485307,0.014014414,-0.026243256,-0.0032760012,0.102484114,0.0006137989,0.04932083,0.008445072,0.014379403,-0.0011134541,0.023984652,0.019196358,-0.08588323,-0.05796084,0.007237104,-0.020993503,-0.017547123,0.017042734,0.011704086,-0.08320758,-0.03371471,0.059549518,0.008710923,0.08512204,-0.042031664,0.028476011,-0.01711549,-0.029631529,-0.01275263,0.010735217,0.0038533052,-0.035003245,0.048421044,0.02355474,-0.042749014,-0.026448352,0.041825633,0.031361256,0.07244019,-0.106730446,-0.022975272,0.020490069,0.028068058,0.0058916793,0.011761532,0.0042251716,-0.011977983,0.023618305,-0.04767944,0.08012899,-0.11265659,-0.0062116073,-0.078830205,-0.038855936,-0.06361216,-0.010827902,0.10169157,0.012999799,0.07622955,0.005712206,-0.04272184,-0.037994392,-0.052907225,0.020581722,-0.08211122,-0.03947688,-0.009737632,-0.0052919458,-0.008114533,-0.0030423235,0.007561725,-0.014464096,0.06627518,0.07095205,0.03142855,0.07416627,0.0039370926,-0.0889699,0.055521466,0.04810892,0.1291571,0.029406443,-0.02791498,-0.022657048,0.07904927,-0.053119633,-0.019291319,-0.02563823,-0.07546909,0.051654484,0.0047475547,-0.036987767,-0.054489892,0.047731657,-0.036811695,0.07011007,0.013775461,0.023839355,0.06473241,0.005859255,0.07174862,0.12766339,0.0025836665,-7.2248215e-05,-0.011022313,0.073569894,0.058289066,-0.05450994,0.05165851,-0.11500125,1.218588e-33,-0.018187093,0.024987118,0.06580894,0.05553025,0.01570682,0.004851116,-0.09209626,-0.026746063,-0.064210996,-0.08963717,-0.11878014,-0.042076875,-0.007321187,-0.084656425,-0.023845427,-0.040946774,-0.06432309,-0.0016444578,-0.019233957,-0.047765836,0.09457731,0.08457139,-0.028327694,0.006658052,0.0643145,0.019179596,-0.017515367,0.026421862,0.08251227,-0.0049727014,-0.055049125,-0.016380811,0.011794502,-0.010285831,0.036590625,-0.046269085,0.03399655,-0.051704567,-0.019868266,0.043425802,-0.0080753835,0.013001083,0.03471939,-0.06596193,0.021743117,-0.0048219864,-0.035262343,0.06561836,0.06977482,0.003884259,0.013921773,-0.03641672,0.049740203,-0.034698993,-0.0046782866,-0.016668309,0.0009266643,0.026191087,0.107082725,0.077665806,0.03296519,0.09738965,-0.010206587,-0.012796886,0.021578388,0.042418286,-0.07069064,-0.07680316,-0.09041718,0.0404195,-0.0321189,-0.009607842,0.14240272,-0.029722437,0.12561212,-0.06908354,-0.0627192,-0.027233236,-0.027176159,0.02824491,-0.121331915,0.0022125868,0.016328003,-0.00013517684,-0.008142174,-0.025568862,0.0056450223,-0.03168416,0.019315599,0.11802511,0.055248585,0.030062929,-0.10728859,0.021526419,0.01163902,-2.1627428e-33,0.024700575,-0.033821274,0.050759353,0.014366663,-0.012572104,0.049318716,-0.0131845195,0.010440892,0.038347784,-0.050702583,0.1795163,0.019795146,-0.05749275,-0.035763945,0.07722768,-0.044239253,0.02882849,0.007211061,-0.043525476,0.025907869,0.0027584457,0.02380483,-0.045807015,0.08312074,0.05003029,-0.0186822,0.035959166,0.08801787,0.03607685,0.01976247,-0.09003621,0.015366675,-0.05762571,0.03339864,-0.123535044,0.0050207833,-0.014425331,-0.050316818,0.0065437746,-0.03898176,-0.054522846,-0.019273324,-0.016383717,0.05940159,-0.0037364278,0.070647776,0.089729086,-0.013502612,0.004995059,-0.0025911506,0.0588593,0.017443387,-0.05436371,0.013351315,0.0034350124,0.008360654,0.031035239,0.06009819,0.072036095,-0.039098915,0.032024648,-0.07680472,-0.024710588,-0.06660033,0.06042198,0.032766197,-0.034862813,0.07765466,0.06416369,0.010707291,0.03252666,-0.058170952,-0.03794693,-0.036461163,0.023792755,-0.05841912,-0.020153526,-0.017101416,0.04759517,-0.08662194,-0.02810315,-0.013899929,0.015997328,0.010729694,0.045067113,-0.020887056,0.0069712563,0.08950803,-0.007718573,0.08192248,-0.053899087,0.048242074,-0.07661504,0.008495476,-0.028225817,-2.3012843e-08,0.012850225,-0.08659658,-0.02988493,-0.034165718,0.077059366,0.05320172,-0.075647525,0.07187653,0.06303952,0.003976484,-0.042367972,0.013973009,0.045316905,0.004857376,0.0137228705,0.047842607,-0.09796716,0.045896802,0.026220702,-0.009958804,-0.07549356,-0.009250318,-0.09110258,0.0054761423,-0.0636269,-0.02279303,0.005680449,0.12560163,-0.011462101,-0.15504573,0.051251758,-0.062211443,0.032013845,0.00011456302,-0.05027491,0.018145308,-0.022405542,-0.04435011,0.03160774,0.044242483,-0.019410297,-0.047078785,-0.058424767,0.07185762,-0.05492986,-0.0014899791,0.030119842,0.02966899,0.008910645,-0.04025502,0.04506436,-0.015750289,0.04322826,-0.062439747,-0.033085644,-0.025036687,-0.008360253,-0.015165535,0.0020745299,0.024003262,0.04261687,-0.018337136,0.08952318,0.0029998529 +2.7.7.72,"The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition [5].",384,0.99999994,-0.05510007,-0.105022006,-0.12887235,-0.023097219,-0.04310453,0.02326526,0.01206735,0.03191453,0.012393521,0.030378038,0.116868414,-0.04495577,-0.09209214,0.006596075,-0.06919897,0.03387693,-0.09280331,-0.022906197,0.03461118,-0.093437076,0.023670299,0.091434635,-0.040503703,0.027156154,-0.010286909,-0.05202527,0.027417239,-0.08976638,0.05308552,-0.002334482,-0.099763416,-0.023720711,0.09159077,0.0048788995,0.011072752,0.0738531,-0.0831436,-0.030163676,0.0769277,0.059437193,0.03649293,0.01948984,0.018357925,-0.06761455,-0.028349964,-0.04516701,0.0716502,0.043143615,-0.004309795,0.050563034,-0.015119919,-0.00625474,-0.075083576,0.021201987,-0.039993636,0.074140616,-0.031591434,-0.05737831,0.008507899,0.0018329271,0.0237253,-0.00075252727,-0.022059862,-0.010910542,0.11199707,-0.052620374,0.040810924,-0.02087505,0.046769604,0.024909865,-0.035468068,-0.0150590185,-0.013622852,0.07576384,0.0021873806,0.017331062,0.05460287,-0.06626313,0.034477606,0.04024832,-0.0034676518,0.01838201,0.05310273,0.0025051092,0.007053838,0.03129095,-0.019166462,0.03254036,0.014313295,0.024580529,0.037464913,0.021207092,0.015025636,-0.0469918,-0.08991894,0.021808213,0.110983156,-0.023622321,0.060706764,-0.03092533,0.026679657,0.02311028,0.013012415,-0.07468519,-0.080354854,0.00035433273,-0.01737423,0.009831844,-0.023900833,0.058775716,-0.004243425,0.029608458,0.061724722,-0.024804505,0.006928313,0.1318801,0.0080030225,-0.05734889,0.068298414,-0.029867617,-0.04254825,0.015691,0.05087984,0.085543185,-0.03698026,0.014879477,-0.07831298,7.6870796e-34,0.018888617,-0.024827523,0.06267313,0.017589783,0.04784238,-0.014030454,-0.070073865,-0.038038183,-0.04503719,0.020729182,-0.057012983,-0.03242601,0.014772746,-0.039628863,-0.039469775,-0.034854006,-0.050185133,0.008922259,0.015786348,-0.010258647,-0.026830403,0.09187867,0.052377194,0.038812354,0.0492605,-0.011844982,0.056974087,-0.00881404,0.017263126,-0.015458218,-0.00200849,-0.023844544,-0.076511785,-0.021199506,0.0967776,-0.02832149,0.007850226,-0.0037502192,-0.01915306,0.078740746,0.06065224,0.021969499,0.014457274,-0.04175926,-0.013180612,-0.027092025,-0.061855912,0.022568822,-0.026409306,0.040590715,0.04809392,-0.013495423,0.018748965,-0.011784069,-0.047047183,-0.0028733802,-0.09314677,-0.0507542,0.098360166,0.04167581,-0.0008154498,-0.019005626,-0.05441078,0.065640226,-0.088729404,-0.019884642,-0.08332448,-0.05354697,0.038188472,0.06260878,-0.06171509,-0.0864103,0.03906642,0.005812752,0.08112424,-0.043855924,-0.09401615,-0.029918998,-0.06462283,0.011087026,-0.059847638,0.009905169,0.0040049483,0.0066932747,0.004674623,-0.03958738,0.018564181,-0.054711618,-0.012687888,0.0059039784,0.02189677,-0.0045488626,-0.008805213,0.051023137,0.074778356,-2.3929061e-33,0.06617189,-0.12581688,-0.0022831263,-0.057384875,-0.094150476,-0.004510838,0.013819918,-0.077816956,0.0075369547,-0.07767072,0.07291547,0.08478949,-0.03161562,0.023211986,0.08239954,-0.02503253,0.05616678,0.06157839,-0.018408952,-0.027073331,0.067798935,-0.038689863,-0.017012276,-0.036516808,0.025796859,-0.028710935,-0.020655025,0.12577997,0.05005732,0.022108432,-0.05595651,0.041571334,0.021779679,0.08249593,-0.10490483,-0.027685324,0.0034165662,0.03245457,0.056924183,0.043620795,0.044521738,-0.008373173,-0.02176287,0.10134983,-0.0034104798,0.044886973,0.020659141,-0.038540557,-0.07243934,-0.06258493,0.09232104,-0.051136836,0.01238502,-0.04869182,0.07495026,0.08687826,0.001172306,0.00916436,0.055028237,-0.0007592644,-0.022442266,-0.012417103,0.020394614,-0.09460615,0.05434678,0.0050441786,-0.09230681,0.018420111,0.0011124084,-0.017503217,0.029348953,0.080169804,-0.044984642,-0.003556035,-0.0038629824,-0.051094487,-0.052446514,-0.06273019,-0.0021596372,-0.10589543,-0.11269382,-0.027139796,0.05215353,-0.014969157,0.016402034,-0.05734092,0.055328682,0.08600742,0.011625406,0.10105381,-0.039555956,0.012926165,0.029158574,0.017829228,0.013151709,-3.8047244e-08,-0.0578544,-0.016845988,-0.02951366,-0.022752935,0.0018657085,0.115449905,0.0154573275,0.07039297,0.064813375,-0.0811402,-0.018866392,0.06837967,0.014998961,0.10608256,0.012992966,0.092471644,-0.12418923,-0.038236257,-0.025069356,-0.042574447,-0.11594082,0.047888946,-0.07533951,0.08489372,-0.06376008,-0.0052895704,0.01482609,0.08317081,-0.026513638,-0.040650673,0.013709516,0.0030402231,0.04210139,-0.036918364,-0.0097198365,0.016662154,0.031672135,-0.04291785,-0.044422865,-0.0072437623,0.027195686,-0.01445941,-0.07114581,-0.00802735,-0.02055223,-0.034761664,-0.03438808,0.037569214,0.007529063,0.030653981,0.058032617,0.007675133,0.017899284,-0.028448671,-0.0034243441,-0.030653771,-0.015274106,-0.083231874,-0.038656488,0.067490995,0.011952579,-0.0009980091,0.14441879,-0.050879583 +2.7.7.28,"In decreasing order of activity, guanosine, inosine and adenosine diphosphate hexoses are substrates in the reverse reaction, with either glucose or mannose as the sugar.",384,1.0,-0.04885909,-0.03705533,-0.020462437,0.0021213253,-0.032412935,0.06040175,0.08264766,0.0415391,0.019599317,0.13247281,0.033530943,-0.00049729337,-0.059480812,0.026384473,-0.051592287,-0.0041179303,-0.017284755,0.013989764,0.051553905,-0.027339924,0.13812761,-0.050063767,0.0012334484,-0.001964077,0.055797987,-0.0006794198,-0.0007243355,-0.04675774,0.018151006,-0.08341923,-0.06733688,-0.017584624,0.054984618,0.0030665651,0.0067933444,0.16039252,-0.023554215,-0.058443863,0.047763053,-0.035397466,0.011013199,-0.0378153,-0.020859217,0.04053002,-0.011617259,-0.018318826,-0.042015232,0.030269362,0.029321287,-0.013141187,0.007601547,-0.024411583,-0.04534691,-0.020878755,0.025572984,0.0054849884,-0.07031386,0.009604557,0.002113264,-0.022243235,0.03485706,-0.012465488,-0.06274915,0.012682627,0.055017386,-0.0374297,0.011127538,-0.011938921,0.014348863,0.05306525,0.009720901,-0.022412783,-0.025628798,-0.015984925,0.029407276,0.021406693,-0.025437277,-0.03487694,-0.049163304,0.005049547,0.043581884,0.039733075,0.07624065,0.044259433,-0.0039212215,-0.055873178,-0.0050152866,0.028336463,0.0506925,0.0062749083,-0.030721283,-0.004473717,0.029727694,-0.03498459,0.0046203686,0.009143757,0.0076454342,-0.04850126,0.074616075,0.0023158477,0.042827703,0.056521,-0.012163924,-0.0058082175,-0.017540868,0.0675807,-0.04271358,0.022329308,0.007582485,0.05473748,-0.025402093,0.033206247,0.03919177,0.012701798,-0.08636818,0.08324233,0.010207262,-0.043855313,-0.04776926,0.0029223147,-0.075682625,0.024220275,-0.012440299,0.053652633,-0.025481181,0.037601702,0.010088245,1.8563497e-33,0.03000955,-0.050808508,0.028576126,-0.09566507,0.013534098,0.02604638,-0.028318565,-0.027045725,0.009138958,0.03712583,-0.08194158,-0.008633139,-0.0030291402,0.05515518,-0.056355447,-0.00393209,-0.008274087,0.025532868,0.083430335,-0.053476363,-0.12816069,0.031253085,-0.041157518,-0.03644776,0.06319898,0.019737402,-0.120075874,-0.00555748,-0.0148744,-0.04467082,0.09404723,0.027162163,-0.04045512,0.01348514,0.02180454,-0.041675095,-0.03728183,0.03324711,0.029930448,0.02523324,-0.003907168,0.05971691,-0.0011261564,-0.07471469,-0.0032314716,-0.04832668,0.039732438,0.01643824,0.04329347,-0.0105139045,0.061692946,-0.020810066,0.018374305,-0.037072606,0.01641358,0.02161857,0.030912865,-0.007326237,0.01271507,0.06732314,0.062373534,0.036113877,-0.024255073,-0.022499,-0.00013702127,0.01362373,-0.11290386,-0.06235596,-0.034981295,0.035162866,-0.059363864,-0.064576,0.019869275,-0.048990443,0.044778157,-0.015011092,-0.06438095,-0.02404145,-0.04632789,-0.0020289947,0.039573845,-0.06609407,-0.04870821,-0.069950804,-0.12937964,0.042753723,0.006907645,-0.14299138,-0.008549608,0.08043081,-0.05404196,0.008736652,-0.09772244,0.0051650153,0.04249839,-4.2234663e-33,0.053003304,-0.06716251,-0.009041186,-0.04004738,-0.09080993,0.038597494,0.05539173,-0.105086304,0.041403297,0.017244864,0.06690082,0.022265408,-0.014461209,-0.00646582,-0.026258528,0.063993506,0.0009142872,0.14635085,-0.037785847,-0.04743692,-0.07203621,0.19742051,0.01738412,0.008531561,0.06988253,-0.034801897,0.031561147,0.071177974,0.07277678,0.007507768,-0.015140665,-0.07383887,-0.0038977186,-0.0031953654,0.003626124,-0.025228368,-0.009616502,-0.0015226726,-0.04332557,-0.022425383,0.06719258,0.07002377,0.10376568,0.063352466,0.05879366,0.021787945,-0.11092012,0.016522488,-0.07743107,-0.05159176,-0.02116666,0.03073827,-0.069162525,0.02849175,0.056151375,0.08232037,-0.012207924,-0.046354163,0.028301667,-0.038265523,-0.01705451,-0.10256054,0.010419388,-0.09596972,0.08996527,0.07809354,-0.112003624,0.036504827,0.07679415,0.029431114,0.011864172,0.012354687,-0.022448558,-0.05750354,-0.01952374,-0.028920248,-0.11151729,-0.059511643,0.022796229,-0.14765854,-0.04083166,0.06504269,-0.05093553,-0.05200447,-0.063596435,-0.0152348885,-0.0020131692,0.060608618,0.024449557,0.08672926,-0.01770754,-0.032374483,0.02248158,0.032864705,0.030758787,-3.237877e-08,0.0642082,-0.040871315,0.09830224,0.04305292,-0.020191586,0.05048167,0.059607737,0.07929345,0.049932655,-0.036906995,-0.041781902,0.12539966,0.09155937,0.022661615,0.035497885,0.0062510646,-0.0636022,-0.0131055135,-0.032305144,-0.059143066,-0.10949413,-0.016971119,-0.077815644,0.0817076,-0.020647699,-0.032734863,0.0857136,0.066609755,-0.019354539,0.011945074,0.03330124,0.030631403,0.017111462,-0.031153668,0.016998235,0.010400874,0.0036822811,0.0033132946,0.021808498,-0.08018751,-0.057053007,-0.02990394,-0.051724464,0.035547037,-0.054663334,0.04303627,0.04762793,0.04324486,0.039099086,0.049796496,0.0066791577,-0.0009244746,-0.04258233,-0.036511153,-0.008078416,-0.05364395,-0.027069518,-0.021988165,-0.01591585,-0.0059839925,0.039053664,-0.017147753,0.118183814,-0.099460065 +2.7.7.31,Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or 2'-deoxyribo-.,384,1.0,-0.06560735,-0.024281586,-0.03509013,-0.06968681,0.02997046,-0.009565144,-0.11125852,0.0305431,0.007425344,0.015801601,0.07056744,0.028947553,-0.08055692,0.018711425,-0.016881559,0.067696616,-0.18955849,0.06395243,0.055700876,-0.0052581965,0.079172805,0.0069903056,0.0063045956,0.02467664,0.04280677,0.053378098,0.06417278,0.01895006,-0.0144713,-0.061051536,0.027528182,-0.04974553,-0.011344803,-0.042445883,0.11750596,0.03900807,-0.04907845,0.007817994,0.0034875914,0.027580677,0.05101964,0.029992674,0.009249839,0.04618116,-0.04693734,-0.021713456,-0.07671567,0.048439898,-0.035269376,-0.012970229,0.0074403193,-0.059156872,-0.037451487,-0.015038777,0.01979692,0.07450442,-0.043949056,-0.01099617,-0.01022083,0.018336592,0.06298986,-0.05346125,-0.05402351,-0.021333829,0.13540532,0.020952657,0.1058993,0.019134404,-0.040155854,0.027376309,0.023412803,-0.07026653,-0.049328383,0.059747435,0.048744213,-0.0022364818,0.0385422,-0.028238064,0.039274763,0.030614803,-0.078958295,-0.012523828,0.040897604,0.03355526,0.032807864,0.031358622,-0.041124232,0.041100103,-0.010619916,0.064703226,-0.06240333,-0.018877536,0.013603038,-0.08976327,0.02190075,0.06230388,0.04995186,0.06325945,0.033010814,-0.052708097,0.0780331,0.050087035,-0.08772837,-0.04384597,0.035325274,0.059059855,-0.008704953,-0.036187757,0.0093742665,0.02969272,-0.012061289,0.009059561,0.019214017,-0.06245285,-0.079486504,0.045344274,-0.00828764,-0.020929351,0.034365345,0.0065627145,0.039092828,-0.03837645,-0.011456747,0.04065457,-0.08858875,0.0033659611,-0.026106892,7.21891e-34,-0.027968088,0.058997806,-0.00051822665,0.08396006,0.041604403,0.014965144,-0.08838273,-0.02406725,-0.168341,0.053834114,-0.11509226,-0.053797778,0.013430276,-0.0026092434,0.0044671986,-0.01770717,0.0186176,0.08243404,-0.041786317,-0.010370857,0.017554536,0.025050776,0.031898126,-0.051574502,0.033996783,0.038357824,-0.034051724,-0.015112016,0.053898238,-0.014851681,0.027001552,-0.07307777,-0.07899107,0.02756531,0.05002684,-0.04028836,-0.042248987,-0.068930775,-0.006276024,0.11534047,-0.009455694,-0.011975419,0.026598293,-0.037675176,0.011997341,0.0014292512,0.074471526,-0.043895148,-0.08186005,0.0062920735,0.031707183,0.018113706,0.030713025,-0.060966063,0.023788135,-0.06192391,-0.0540054,-0.008714938,0.057192408,0.051573656,-0.0022618757,0.04319129,-0.035592295,0.0035706104,-0.00801957,-0.013295816,-0.056621917,-0.0040887697,0.075007215,0.0732369,-0.005740874,-0.033000436,0.018050447,0.0044285594,0.022829808,-0.0028738938,-0.08088545,-0.018561808,0.024706315,0.05347739,-0.052648168,-0.0040841163,0.00041814658,-0.009746788,0.015036847,0.022388529,-0.037020564,-0.07306515,-0.038865387,0.04981247,-0.026686672,-0.031952012,-0.030944727,-0.016366368,0.09498466,-3.3302005e-33,0.068126984,-0.08548967,0.015674481,-0.12884818,-0.059814073,0.004410226,-0.0044933846,-0.06546953,-0.0026457135,-0.03393888,0.048364908,-0.026909538,0.046953738,-0.046672843,0.010965941,0.047112092,-0.048870336,0.0028042132,0.002789711,-0.005558734,0.047864877,0.008372468,-0.06838359,0.082513295,0.04094303,0.028886259,-0.004890532,0.046380483,0.09256856,0.009273139,-0.06473167,-0.02463077,0.067423165,0.030697076,0.017202262,0.15382145,-0.028039422,0.032960836,0.04873663,0.009796886,-0.021487221,0.07664522,0.005158858,0.047430143,-0.02346091,0.033240806,-0.050157353,0.054030873,0.018553134,-0.03258243,0.025816988,-0.0068156747,-0.030246831,-0.018343214,0.025810769,-0.0005210058,-0.058255825,0.0042389575,0.050501317,-0.012285665,-0.03375575,-0.022024784,0.039015736,-0.028453005,0.06502857,0.035009533,-0.07032988,0.015988098,-0.028408347,-0.06594952,0.03384619,0.07546951,-0.028141508,-0.01622053,-0.019353578,-0.05197701,-0.09173758,-0.04978147,-0.010321497,-0.0727187,-0.050260488,-0.038403045,0.001184651,-0.001824317,0.060006455,-0.10314004,0.08293285,0.116222866,-0.04801414,-0.034517158,0.044291034,0.054317687,-0.036455024,0.16391252,0.011633421,-3.4311174e-08,0.044885997,-0.045256957,0.01969647,-0.07031725,0.043831382,0.04811327,0.038316827,-0.022605523,0.05557065,-0.0340812,-0.014823602,0.06673256,-0.013342057,0.032039024,0.085717715,-0.0017413367,-0.08935514,-0.0444944,-0.025734738,-0.021605866,-0.07125794,0.07152017,-0.15124662,-0.0021461535,-0.067766525,0.03034573,0.00054061523,0.045301296,0.038963113,-0.032902576,0.05589955,0.058622137,-0.029470518,0.0065502673,-0.024659637,0.00019283422,0.039427694,-0.020298121,-0.050641764,-0.011089619,0.0014611764,-0.0070295753,-0.07006973,0.029071191,-0.10737422,-0.04686804,-0.011227106,0.00020833837,-0.06464605,0.03258731,0.07827947,-0.030246263,0.018328888,-0.03018789,-0.035954755,-0.04206369,0.011238404,-0.027474385,-0.049570456,-0.01768782,0.022780385,-0.08594242,0.20611265,-0.055942126 +2.7.7.34,"Also acts, more slowly, on D-mannose 1-phosphate.",384,0.99999994,-0.030137368,-0.123750396,0.04942147,-0.022857081,0.014971535,-0.0501609,0.020922367,0.035636656,0.04436176,0.11490277,0.035209548,0.03809475,-0.047366444,0.07468687,0.009435858,-0.010013761,0.010830784,0.029240482,-0.034503825,0.034460027,0.10563067,0.011705544,0.026167067,-0.024146643,0.039661407,0.0015910995,-0.0008356416,-0.009949524,0.005754361,-0.14267449,-0.028033607,-0.012538302,-0.014381931,-0.03223491,0.04732179,0.10417358,0.03306545,0.042951345,-0.00069033477,-0.040069632,0.050914392,-0.07287512,0.026057208,-0.006873918,-0.03419946,-0.02320241,-0.07588146,0.026191786,0.016967233,0.010912706,-0.07940932,-0.05249852,-0.030587368,-0.030162666,0.0001983056,0.024903903,-0.05559013,0.086149804,-0.011733813,-0.056146108,-0.05162758,0.006101087,0.061783306,0.037183903,0.11458724,-0.03908309,0.06634307,-0.075210094,-0.014617522,0.0149065275,0.010836596,0.0037836474,-0.034157857,-0.035520565,0.02602717,-0.06160155,-0.050009307,-0.10107347,0.038571615,-0.0030869292,0.013536997,0.053027127,0.032257907,-0.0006491502,-0.046517387,0.026532765,0.015168725,-0.061677825,-0.039446533,-0.02648507,0.015687324,0.031020803,0.0071190475,0.010592557,-0.0064979247,0.003191093,-0.0035715522,0.0454832,-0.015589794,-0.028862067,-0.022735441,0.08803445,-0.07552697,-0.044257995,-0.013842405,0.019910855,-0.0024948828,0.013713634,-0.04912209,0.06676304,0.037496906,0.037782013,0.015990047,0.07837438,-0.099272504,0.036931403,0.0039712153,-0.014217734,-0.05665145,-0.046334885,0.008213137,-0.06528001,-0.033157803,0.03889673,-0.029883567,0.03574439,-0.004146,-3.6632974e-33,0.06747337,-0.04690505,0.029253049,-0.022622578,-0.008385269,-0.02533703,-0.07720577,-0.028053869,-0.0612986,-0.019100059,-0.068222515,-0.08393503,0.017202305,0.037114836,-0.10171773,-0.013552588,-0.035971016,0.057561066,0.011352249,-0.07219646,0.04387708,0.08336468,-0.05145351,0.0099471845,0.03944654,-0.0085671535,-0.046785984,0.05943146,0.0055089565,-0.020539105,0.061879426,-0.042539056,-0.075307,0.02256919,0.04183902,0.012686101,-0.058999993,0.0051233936,0.05758111,-0.029781967,-0.044743966,0.016295156,-0.063019335,-0.060732257,0.011052507,-0.043954007,-0.017852336,0.056383435,-0.034422897,0.07613022,0.087378815,-0.05007987,0.032322362,0.007672129,-0.019656388,0.013070666,0.030585082,-0.07778459,-0.0021785242,0.10153881,-0.011679321,0.0023594317,-0.013848541,0.019531025,0.011879763,-0.014087336,-0.085031115,0.014528036,0.038102616,0.03019829,-0.0487886,-0.044999413,0.10247428,-0.051477075,-0.0028625045,-0.031416968,0.012558164,-0.008378997,-0.02270163,0.036807325,0.06570835,-0.08786712,-0.025415458,-0.047297068,-0.07356361,0.009484782,-0.015915023,-0.15625185,0.0010099007,0.036976054,0.060859233,-0.07560024,-0.1229016,-0.026304504,-0.015373792,6.4423955e-34,0.06340685,-0.061795637,0.06161542,0.064202495,-0.056937687,0.029542692,0.056444846,0.023947474,0.071791105,-0.035065413,0.07329017,0.0175211,-0.078235485,-0.006582244,-0.021339234,0.07986213,0.055578895,0.066777915,0.027282735,0.032602906,-0.02839762,0.1494378,0.0018635,0.10756241,0.039335333,-0.0017269853,-0.044500016,0.03043419,0.006204721,0.046546783,0.015672728,0.012932655,-0.07129608,-0.0595964,-0.05746335,0.013553242,-0.057146817,0.0051000607,-0.033301096,-0.016775941,-0.029291209,-0.02381105,0.11405481,-0.0033061998,0.042563055,0.04956269,0.03067662,-0.026403427,-0.08994304,0.0478447,0.006342766,0.034429338,-0.0065545253,0.06512111,0.08721008,0.066512585,0.012318831,-0.008458911,-0.06128658,0.02181068,0.008836306,-0.024580486,0.018287344,-0.053837307,0.062244095,0.038517747,-0.05029006,0.048347376,0.11834139,-0.008899041,0.07873376,0.04129134,0.02898655,-0.00013713387,-0.055321567,-0.05330379,-0.08394381,-0.04950114,-0.01189974,-0.03910847,-0.08464083,0.0720187,-0.04164416,-0.09232298,-0.07142112,0.004073059,-0.008269668,0.03068855,-0.040855277,0.092143536,-0.07902351,-0.010155931,0.017436637,0.060061045,0.044197004,-1.9832553e-08,0.090037026,-0.0017175117,0.10381775,-0.035099328,0.015098252,0.0094839465,0.06718515,0.10948637,0.032480925,-0.01879811,-0.044719864,0.12251825,0.09263333,-0.030787472,0.09888053,-0.0036695336,-0.052677482,-0.033317126,-0.08625281,-0.048585944,-0.08089186,0.0063059274,-0.08300565,0.019621145,-0.043029223,0.016808411,0.060806524,0.048289698,0.0066039795,-0.04047255,0.042764306,0.007506023,0.010461483,-0.0787836,-0.043191817,0.032155134,0.00080455403,-0.014954854,0.005667012,0.0129935695,-0.04359253,-0.024097001,0.011793696,0.03270136,-0.058037676,0.04424779,-0.042376876,0.0014989612,0.0022442164,0.009012653,0.044670217,0.037048116,-0.13224287,-0.056226783,-0.07878394,0.072115004,-0.0069952137,-0.018111467,0.06583663,-0.013745796,0.07232544,-0.056300987,0.10668546,-0.029149909 +2.7.7.35,"The enzyme, characterized from the single-celled alga Euglena gracilis, catalyses an irreversible reaction in the direction of ADP formation. cf. EC 2.7.7.96, ADP-D-ribose pyrophosphorylase.",384,1.0,-0.06019069,0.0151405595,-0.062042095,-0.017398514,-0.03419834,-0.0075975396,0.008747467,-0.055143714,0.005260557,0.045769796,0.017792195,-0.02289134,-0.11614033,0.007250217,-0.050990906,0.044123713,-0.08834922,-0.07675934,0.047654524,0.028097842,0.050443217,0.020183193,-0.027319338,0.016788771,0.07348366,-0.018478282,0.031925302,0.029521322,-0.07817471,-0.088393465,-0.007817938,-0.020788968,-0.009031432,-0.0010423586,0.0518801,0.077426046,-0.076639615,-0.028845645,-0.009143423,0.013786046,0.08375038,0.036905874,-0.054727092,0.0039214804,-0.05919601,-0.025437845,-0.018044202,0.0648321,-0.03169981,-0.002082268,0.0038090001,-0.003840841,-0.054769933,-0.070349015,-0.0042796093,0.026266774,0.007777337,-0.014409691,-0.011031274,-0.033311006,0.037658866,0.011944531,-0.015026018,-0.011737238,0.04378561,-0.051410586,0.09938094,-0.10338726,0.0055009513,0.026419848,-0.06538994,-0.07860269,-0.06437177,0.040729415,0.05478114,-0.002267625,-0.035362147,-0.078143544,0.07806519,-0.008841005,0.056331586,0.0019430185,-0.04337632,0.07361205,-0.015468805,-0.056463487,-0.008390183,0.02727745,0.09308899,-0.06090578,0.00045703776,-0.01627266,-0.031946294,0.028705245,-0.026247902,0.063572735,0.0016155528,0.034126338,-0.030611372,-0.066008896,0.0012110726,0.064038604,0.019496264,-0.080462456,-0.013268753,-0.018599888,0.026856968,0.098991305,0.0022571732,0.005277553,-0.01893134,0.00052939256,0.059467815,-0.016692488,0.013103364,0.05567744,-0.059208035,-0.082113594,0.007186608,-0.052633736,-0.009556577,0.015844181,0.036858894,0.098864,-0.0127007,0.03890847,-0.06872219,4.1134763e-34,0.04071683,-0.005359883,-0.027694209,-0.011570774,0.059470925,-0.034933984,-0.07165014,-0.06457447,-0.06677963,-0.014520689,-0.053612072,-0.024299698,0.049734518,0.0422065,-0.034942202,0.00085010845,0.007004198,0.04211429,0.029072532,-0.007014105,0.0018265634,0.077863075,-0.060779132,0.0012093589,0.021264529,0.07254633,-0.04965474,0.03649201,0.014617424,-0.02764313,0.04696334,-0.05684733,-0.16224477,0.014194056,0.046281654,-0.013891702,-0.046731696,-0.045914218,0.061642855,0.025092507,-0.01162834,0.03891094,0.0731508,-0.042936128,0.082665406,0.021269398,-0.10811148,0.13226095,-0.012766261,0.032658245,0.10238179,-0.0147526665,0.10454257,0.0025545482,-0.09662884,0.09458262,-0.048999086,-0.025131693,0.06672307,0.039923865,-0.0073314672,0.043723203,-0.050822254,0.017852498,-0.060816344,0.040653087,0.0043459754,-0.08143396,0.022680404,0.05940687,-0.044749398,-0.02081238,0.082858406,-0.04079537,-0.047274385,-0.021193968,0.012897269,-0.031065902,-0.0878385,0.08414364,-0.08928119,-0.031948067,0.002172953,-0.005565591,0.011818481,-0.009470108,-0.009616967,-0.0076248753,-0.0026896957,0.09239247,0.02306419,0.05184304,-0.082493946,0.007522827,0.04071197,-2.6141369e-33,0.09653568,-0.11779799,-0.002738112,-0.07745056,-0.064629994,0.03659357,0.03272478,-0.04592579,0.025595726,-0.052706394,0.07042973,-0.00038951542,-0.012410858,-0.035564747,0.011998004,-0.0074330512,0.014153865,0.113833584,0.02692813,-0.0050275754,0.001201996,0.09794496,-0.029616326,0.057905506,0.08561737,-0.10319305,0.011631996,0.048506588,0.033148862,-0.039372694,0.022620335,0.01226153,-0.022538323,0.016670654,-0.060002677,0.05083886,-0.034229964,0.038322963,0.014859356,0.030734222,0.043171633,0.03471693,-0.029440898,0.05053991,0.083970726,0.09514684,-0.019726422,0.029560812,-0.049161714,0.0058640395,0.021971188,0.02203323,0.012914376,-0.021011071,0.016126936,0.099284306,0.08804362,-0.026497329,0.009269167,-0.03173249,-0.022236252,-0.00036906215,0.08893968,0.005845433,0.008685432,0.10162802,0.009307527,0.018696932,0.024435585,-0.032169025,0.09300458,0.099519685,-0.08374359,0.026534643,0.00619353,0.045216806,-0.090082906,0.033027917,0.017515432,-0.09021496,0.029175464,0.036002237,0.032320786,0.0050662905,-0.032736037,-0.0967394,0.015277676,0.11650577,-0.027845463,0.07613062,-0.01043932,-0.080298945,-0.03659759,0.028689232,-0.005075786,-3.315298e-08,-0.02021693,0.07255445,0.050350316,-0.070646994,0.012435388,0.059509974,0.02079376,-0.00213778,0.08962214,-0.07512986,-0.009353745,0.050486982,-0.036621146,0.05084397,0.01139365,0.04259978,-0.058629453,0.0016346314,-0.040660374,-0.012810783,-0.038783036,0.02759787,-0.14777185,0.114025615,-0.025553878,0.0064768386,0.0036152024,0.013628789,0.028054018,-0.044419345,-0.0036045662,0.0078062858,0.017588476,-0.038757868,-0.0046780864,0.038388014,-0.0119309435,-0.06936713,0.0007659704,0.0059959847,-0.07104014,-0.038511556,0.028867558,-0.06937702,-0.074680775,0.015863506,-0.016632246,-0.06704932,-0.020960895,0.035162188,0.08848058,0.0125871375,-0.011834063,-0.076199405,-0.103698656,0.018595979,-0.073131524,-0.10522455,-0.02138876,-0.007479783,0.06693577,0.022524077,0.095767826,-0.039181717 +2.7.7.37,"The enzyme works on a variety of alpha-D-aldose 1-phosphates and beta-L-aldose 1-phosphates (which have the same anomeric configuration as the former; see 2-Carb-6.2).",384,1.0,-0.090609126,-0.07936714,-0.06349716,-0.029316088,-0.017281273,0.022985574,-0.1023889,-0.029096508,-0.015668012,-0.030138424,-0.012629959,0.00076312566,-0.110828936,0.043154553,-0.038515013,0.07292421,-0.027870717,0.022654219,0.056578234,-0.025096977,-0.008024245,-0.003073429,0.017598744,0.018686345,0.0384219,-0.05611666,0.013975968,0.013417862,-0.049872104,-0.10217493,0.019993635,-0.079633005,0.034378946,-0.0048816144,0.036850348,0.078838386,-0.028198147,-0.039041318,-0.036381382,-0.0045380434,0.061996922,-0.040080193,-0.013388891,0.0014416084,-0.011421287,-0.021474857,-0.052636784,0.10098984,0.038977824,-0.016510135,-0.050688993,-0.13580719,-0.053194135,-0.038498435,-0.018268356,0.050662868,-0.07984626,0.08293449,-0.00893459,0.021174476,0.06488404,0.044535633,0.013675209,0.06637104,0.03253891,0.014387284,-0.030969921,-0.0573482,-0.07238307,-0.07827596,-0.0607832,-0.12667094,-0.010524247,-0.023808053,0.021639246,-0.004856516,-0.1066666,-0.012098776,0.035694588,-0.052415684,0.04011,-0.043107096,0.0614822,0.048810747,0.04306457,0.016284108,0.0068590716,-0.00789968,0.044827845,-0.0011510012,0.059856556,0.010408222,-0.02515863,-0.04526496,-0.025498915,-0.052270193,0.026015721,0.036981,0.008787102,-0.020511022,0.029781772,0.0963636,-0.024888529,-0.028279886,-0.03149004,0.07922853,-0.0572147,0.091233306,0.040147025,-0.013485369,-0.025900466,0.087879725,0.060097877,-0.013134941,-0.015411817,0.09332996,-0.04227013,0.0072979727,-0.0080939755,-0.0058611943,0.0067419223,-0.026017314,-0.009150256,0.06933177,-0.053755533,0.092061035,-0.116773136,-4.5381934e-34,0.056966588,-0.012185599,0.04278406,0.023203867,-0.029689543,-0.0043663806,-0.07749896,-0.01498154,-0.07804855,-0.042088486,-0.04299546,-0.036451984,0.067477636,0.07906229,0.019734314,-0.022461446,-0.007197072,-0.007178322,0.022811087,0.005372689,-0.0133111905,0.046769828,-0.073151335,0.06326505,0.044972103,0.06198486,0.015368535,0.048457544,-0.017487198,-0.0024986714,-0.06492522,-0.0387784,-0.122456916,-0.009014952,-0.018768227,-0.01694473,-0.041362178,-0.00072616397,-0.018430686,0.032716442,0.075111575,0.042945694,-0.0084799705,-0.04946706,0.005093365,-0.06306084,0.02074482,0.118128106,0.08039373,0.06862698,0.02991884,-0.05523433,0.034623403,0.012355561,-0.017248437,0.10228635,-0.05026281,0.038598597,0.024083445,0.007000777,0.06341452,0.045796398,0.019481698,0.02546575,-0.036609862,0.05982626,-0.09920112,-0.08690601,-0.020777555,0.12568125,-0.08227101,0.05855541,0.07737415,0.012834566,0.029569918,-0.032105472,0.014759062,-0.003946093,0.01896834,-0.031989142,0.051778108,-0.010076623,0.09956973,-0.013227552,-0.022341667,-0.05565532,0.0068257432,-0.060310345,-0.08074438,0.03788047,0.08343094,-0.02925382,-0.05682527,0.010932482,0.04243042,-8.895221e-34,0.12959962,-0.09737992,0.12901649,-0.030746806,-0.040320326,0.03955628,0.05929299,-0.11386856,0.058405142,0.004050549,0.07964492,0.070364036,-0.0010722323,-0.069962405,0.02794748,0.04447337,-0.018164525,-0.0034911272,-0.007852508,0.0067753745,-0.035886545,0.02902826,0.0104210265,-0.010660537,0.05203965,0.0065658283,-0.0024558038,0.02648396,0.08047876,-0.024494361,-0.031145757,0.018388612,-0.036161836,-0.021278944,-0.043563515,0.096803755,-0.10277422,-0.00472719,0.0055207927,0.07115043,-0.022026764,0.01796292,-0.029799797,0.03353191,0.027523912,0.058748554,-0.0054440987,0.0013163465,-0.036760554,-0.06605656,0.058022395,0.0034120083,0.011287934,0.03967154,0.013442049,0.043562755,0.052324016,-0.013856645,-0.11308611,-0.016225733,-0.010136531,0.011820988,0.03919518,-0.016760763,-0.012472132,0.0059030754,0.006529932,0.030727971,0.014564422,0.031676218,0.108732276,0.016509112,0.061142154,0.050986737,-0.01872184,-0.03251761,-0.05265182,-0.006599058,-0.011976922,-0.04358928,0.0059937066,0.021746453,0.009969703,-0.0076648886,0.049576495,0.029629014,0.047514014,0.10608349,0.050559163,0.0682691,0.0044443663,0.00037046385,-0.026828283,0.021112522,0.101757824,-4.5608957e-08,0.0718162,-0.1022982,0.032598957,-0.11763782,-0.018444179,0.039784674,0.012480635,-0.015099709,-0.041386727,-0.036274187,-0.08205205,0.09434401,0.021870248,0.024049625,-0.006374197,-0.029786978,-0.008856864,0.009592826,-0.051927317,0.031206194,-0.0648531,0.024227904,-0.1084159,-0.023616623,0.008280008,-0.10342259,-0.023370974,0.03900081,0.0014150045,0.025353186,0.01765865,0.013126483,-0.012073563,-0.104324855,-0.005529346,0.052191157,-0.0607082,0.011862336,-0.052676115,0.01954583,0.032896478,-0.11135418,-0.025756828,0.016650377,-0.016885746,0.01846566,-0.015909692,-0.024612224,-0.012367745,0.047861513,0.059128422,0.028928265,-0.098679855,-0.06433831,-0.035355754,0.028693097,0.0027978104,-0.05863812,0.022191027,-0.12774575,0.018197807,-0.006184931,0.11200135,-0.06497001 +2.7.7.39,Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls.,384,1.0,0.0061450275,-0.06859975,-0.1231337,-0.014408726,0.0071366145,0.10198822,-0.11325975,0.070248365,0.094672196,-0.051471483,0.06147834,-0.10014791,0.04367516,0.019407168,-0.031109521,-0.05216365,-0.033288524,0.03695586,-0.031947773,-0.045880057,-0.011757466,0.059990026,-0.028831413,-0.022657892,0.015296882,-0.004288498,0.031809572,-0.015981138,0.011603703,-0.035068702,-0.00038522496,-0.035327338,-0.000612043,-0.09339285,0.09011274,0.047347773,-0.02513893,-0.02810541,0.13825873,0.023103224,0.023243016,0.014544362,0.0071288943,-0.009784891,0.01754507,0.07165391,0.032210622,0.045828976,-0.0013524374,-0.015757067,-0.06748637,0.09031189,-0.05203498,0.044038944,0.0051414296,0.089885205,0.05555716,0.02556425,-0.0060252794,0.016222063,-0.010799298,-0.057071567,0.057995267,-0.021706294,-0.071444675,-0.04103768,0.04596382,0.024788264,0.03121957,-0.02178589,-0.03380433,0.020431409,0.08468837,0.049892217,0.0026825035,0.080581084,-0.00035952468,-0.04601986,-0.034681756,-0.011871865,-0.034218427,-0.05274771,-0.084288076,0.04799811,-0.015688298,-0.07831837,0.007630252,-0.019798411,0.06646836,0.094224446,0.062925726,0.03422061,0.0463577,-0.09195124,-0.038985822,-0.014431328,-0.016584994,-0.03990543,0.01823042,-0.10412403,-0.04916725,0.035986345,0.0016216863,-0.036381595,-0.017561909,-0.028547836,-0.0062070303,0.16910511,-0.0004116051,0.02721817,0.08933129,-0.06630442,0.021344326,-0.038674545,-0.0033701079,0.0066923457,0.05880218,-0.16026649,0.0016288249,-0.018785061,0.032204647,-0.005225311,0.025386259,0.04330575,-0.05494461,-0.041660104,9.9413264e-05,-1.7814374e-33,0.11489694,0.029112065,-0.06694263,-0.029537804,0.01767726,-0.013258966,-0.09356396,-0.06807586,0.02839331,0.008187557,-0.105318904,-0.0899519,0.00027005083,-0.0036145353,-0.011961105,0.051697962,-0.04715147,-0.012816681,-0.013883268,0.043838464,-0.0511042,0.10733119,0.033476815,-0.008539812,0.028130574,0.05218639,-0.009385226,-0.05957006,-0.04077928,-0.0139366845,0.026127698,0.012897201,-0.084789835,0.017215732,0.15879652,0.03957106,-0.07565136,0.020262547,0.0038358122,0.002118789,0.021511786,0.07625241,0.037922457,-0.027999908,0.07811534,0.020062145,-0.0045154137,0.03310633,-0.017347893,-0.021538422,0.06470602,0.032032758,0.09646317,0.029039087,-0.053074643,-0.049710833,-0.07179435,0.036447324,-0.016494049,0.057861764,-0.036491986,0.04857562,-0.031804036,0.06789383,-0.039263435,-0.02228771,-0.0635133,-0.0039342768,0.039843116,-0.030476654,-0.0065401336,-0.06626523,0.082859345,0.008344188,-0.046838325,0.0100656,-0.08583995,-0.0114767635,0.042239882,-0.039215103,-0.0138407415,-0.006016476,-0.032510884,-0.027995532,-0.019442119,0.035584357,-0.007695905,0.022115959,-0.040506102,-0.013839895,0.10529931,-0.050724912,0.0101537835,0.08178236,-0.037692565,-1.42877665e-33,0.06808534,-0.08279869,0.055592276,-0.08404459,-0.036900904,0.028809497,-0.0753122,-0.011839163,-0.018778482,0.028770523,0.054128956,0.039081186,-0.021414014,-0.0029668403,-0.00080243626,-0.007006227,0.08686841,0.062308498,-0.038309574,-0.092922926,0.026169566,-0.05213196,-0.021866264,0.0011364372,0.052093104,0.07408534,0.0027761764,-0.006118084,0.040071823,0.023869025,-0.00913637,0.030390382,-0.09359005,-0.03572115,0.04161386,0.07994359,-0.0062827654,-0.007290775,0.07183946,-0.011958664,0.093568824,-0.009608,0.013891502,0.004830444,0.032962233,0.059874292,-0.011689995,-0.08381224,-0.10687952,-0.027865192,0.010709866,-0.017908113,0.0053585027,-0.06453199,0.0032918353,0.019097213,0.009031315,0.07222154,0.021530233,-0.075373664,0.0026885383,-0.10554532,0.022792224,-0.052110452,-0.07496391,0.017358761,0.03537393,0.039993312,0.06185592,0.0065794154,-0.030284982,0.093022935,0.054107916,0.010568627,-0.003768775,-0.032481067,-0.08287288,-0.085596375,0.010547291,0.020408023,-0.047669485,0.014934234,-0.020739537,-0.04884214,0.07283886,-0.061264377,0.02309753,0.088665016,-0.0076537705,0.01207651,-0.026381748,-0.025943156,-0.013422385,0.027119165,0.061603736,-2.3471873e-08,0.06444451,-0.049912866,0.024952173,-0.052703127,-0.019950856,0.016396504,-0.017535111,0.038468104,0.031650305,-0.010448539,0.021077462,0.022150017,-0.041305132,0.048087303,-0.034913316,0.05539493,-0.09786373,-0.10310521,-0.004003595,-0.03277379,-0.07497261,-0.014112399,-0.076841556,0.054650515,0.011684718,-0.052601893,-0.06879787,-0.04973044,-0.033758484,-0.037616137,0.06725627,-0.021240145,-0.042185254,-0.0057831793,0.0008508312,0.006312283,0.0121731935,-0.049339164,3.7955968e-05,0.026831219,-0.0039575887,-0.045072313,-0.10356261,0.05408386,0.085194245,0.046302993,-0.042789772,0.11295906,-0.09157425,-0.03443954,0.016481344,0.008313283,-0.014125901,-0.014253913,-0.060855865,-0.04110575,0.012957516,-0.057188194,0.015713345,0.037208498,-0.035478424,0.056867667,0.062504806,-0.09975228 +2.7.7.42,"This bacterial enzyme adenylates a tyrosine residue of EC 6.3.1.2, glutamine synthetase. The enzyme is bifunctional, and also catalyses a reaction that removes the adenyl group from the modified tyrosine residue (cf. EC 2.7.7.89, [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase) [7,8]. The two activities are present on separate domains.",384,1.0,-0.031077715,-0.0058834055,-0.03982008,-0.03913783,0.022352472,-0.018886328,0.043173824,0.0075760325,0.07335339,0.017297694,0.04045217,-0.045481633,-0.024078757,0.033083275,-0.023930693,0.00724713,-0.12130324,-0.06769595,0.009803654,-0.086915225,0.045826487,0.10791251,-0.013987514,0.031632625,0.018873103,0.01851428,0.07690029,-0.008879095,0.00019440395,-0.053519644,-0.05282299,-0.04492138,0.07357163,-0.031014467,0.09134436,0.08148229,-0.054448858,-0.04891867,0.10389483,0.0033102636,0.00719721,0.014019453,-0.02408144,-0.040508624,-0.04875058,0.05543991,0.10377613,0.055423524,0.021878786,-0.0013709057,0.04604715,-0.07695843,-0.013404256,-0.025555447,0.07626518,0.01314996,-0.08288867,-0.045735966,-0.016246762,0.03559918,0.025466047,-0.00028418543,0.019998675,-0.05190954,0.050606515,-0.06680795,0.1037471,-0.12732612,0.007894668,-0.07148526,-0.06948274,-0.07653326,0.059926476,0.021909352,-0.0021575822,-0.0030422749,-0.0022979008,-0.024005506,0.04797632,-0.011448624,0.035285555,-0.08610155,0.023108331,0.0674085,-0.01859269,-0.055119663,-0.010798755,-0.020710502,0.11857852,-0.0016941717,0.030994058,-0.04967518,0.036176134,-0.09146604,-0.0071328958,-0.02969653,-0.014482135,0.017902087,0.031042663,0.003329691,-0.030584896,0.057611156,-0.03837504,-0.005662935,-0.0047264863,0.038139705,0.011157267,0.14240116,-0.0064588017,0.00036318673,-0.0144658955,0.05399552,0.07522402,0.0076629906,-0.054781154,0.073150605,0.052807663,-0.045364585,-0.084032655,0.0007924766,0.029406775,-0.02494877,0.066806994,0.0972397,-0.07252294,0.044570588,-0.056731828,2.0561914e-33,0.036721557,0.074355036,0.0021336328,-0.09195417,0.026877515,-0.0038113631,-0.071264334,0.005984993,-0.023477752,-0.06342898,-0.092920445,-0.041519567,0.05227344,0.011330363,0.024573056,0.009603904,-0.04829223,0.038907267,0.03510873,0.026378134,-0.006946562,0.04564492,0.022531383,0.008144118,-0.0034535965,0.082096785,-0.024087016,0.010114874,0.05112458,-0.02082651,-0.003511693,-0.0507787,-0.097997025,0.022830293,0.005586485,-0.020535508,-0.060406286,-0.014891202,0.027857864,0.06293779,-0.024518952,0.052038707,0.024043351,-0.07255073,0.03402465,-0.04896847,0.015610232,0.11673686,0.046515778,0.08166173,0.050687358,-0.032474432,0.08237629,-0.083973326,-0.04367801,0.019900555,0.0030556098,-0.04942273,0.050624333,0.056951825,0.056915782,0.05317384,-0.029618055,-0.025368057,0.0073478916,0.0410854,-0.047415983,-0.05520026,0.02563677,0.09237122,-0.029062774,0.002221129,0.07325398,0.10119103,-0.047689933,-0.023821497,-0.07113213,0.0014270564,-0.0145484535,-0.012825747,0.001442869,0.0111899525,0.061664477,0.006530412,-0.0127083,-0.033635728,-0.021664584,-0.03477616,-0.07658672,0.056441307,-0.008869418,-0.05296706,-0.09938099,0.024302611,-0.0301712,-2.596508e-33,0.11935057,-0.08667684,-0.03887427,-0.09921137,-0.047189254,0.03883205,-0.004391499,-0.02903485,0.0030435636,0.003720552,0.041221794,0.022534866,0.03605015,-0.07183817,0.0063879997,-0.096874714,-0.0047132657,0.0885157,-0.07531843,-0.0339894,0.052633546,-0.012355948,0.009732755,0.012736579,0.029572133,-0.0126194125,-0.016496,0.06193232,0.003059856,0.046434883,-0.06631598,-0.02752728,0.023588454,-0.04261181,0.05579163,0.044559706,-0.019803908,-0.006637332,0.010024824,-0.0132073555,0.05166955,0.05300609,0.031516418,0.06587806,-0.00025697376,0.11878926,-0.058171477,0.035525635,-0.078388825,-0.051484294,0.0363838,-0.02490544,0.037254017,-0.07714,0.013764474,0.058666307,0.037501402,-0.008556679,0.004386339,-0.0002884234,-0.009988878,-0.025928061,0.009928946,-0.0072772433,0.044825066,-0.004062414,-0.04235716,0.047796313,0.038859006,0.022625102,0.033891447,-0.041552342,0.04182447,0.006474545,-0.01991737,-0.015596572,-0.03950354,-0.06533157,0.06387879,-0.08366612,0.021767944,-0.020101016,0.029811064,0.009080962,-0.00975132,-0.006379099,0.0317685,0.14165688,-0.019120114,0.057385415,-0.028860342,-0.008013206,-0.03769213,0.028156588,0.028864732,-4.0296005e-08,0.049927756,-0.08514287,-0.0026838982,-0.045611314,-0.00040173635,0.12496322,-0.03624776,0.029101117,0.042024635,-0.06413854,-0.009920311,0.06840213,-0.03689093,-0.019499918,-0.08622178,0.010207116,-0.07946469,0.03449838,-0.050687738,-0.06459052,-0.08416626,0.018445017,-0.11599193,-0.013786209,0.0599918,-0.059481774,-0.002444735,0.09113647,-0.068376,-0.018959964,0.01243153,-0.018602964,-0.047371313,-0.035949443,-0.0295444,-0.04401435,-0.052392002,-0.008841499,-0.032749604,0.0566293,0.037921574,0.027567869,-0.08433342,0.0102713425,0.014898927,0.060907595,-0.021440152,0.0031297503,-0.034964554,0.036903396,0.09090201,-0.009200741,-0.000765501,0.0063435137,-0.12879653,-0.055572476,-0.03744005,-0.094252154,-0.0121166315,-0.055100486,0.06437243,0.041877013,0.18482427,-0.021038508 +2.7.7.43,Acts on N-acetyl- and N-glycolyl- derivatives.,384,1.0,-0.065525636,-0.09576394,-0.080016226,0.028223611,0.009427041,0.021019762,-0.0093389405,-0.029003732,0.03866684,-0.05701319,0.077874586,0.092925824,-0.11126259,-0.038593337,-0.057783574,0.032385282,-0.010915354,-0.0056168046,-0.03483243,0.020318653,-0.012289953,-0.036919042,0.0035948935,-0.01674851,0.028042126,0.028275922,0.012200685,0.061822176,0.03154988,-0.117469646,0.05601168,0.010201292,-0.030757813,-0.038593557,0.016050883,0.0040906426,0.0021234788,0.049006168,0.061546013,0.0017815649,0.017735984,-0.08782289,-0.04475469,0.009599558,0.028109806,-0.088022016,-0.02228975,0.020719117,0.01210438,0.05441603,-0.003132777,-0.016913738,-0.01673731,-0.0334424,-0.026887763,0.03647415,-0.19959569,-0.007071938,0.10265974,0.06263767,0.03129437,0.00586648,-0.019860577,0.040986564,-0.02744861,-0.017871516,0.09350889,-0.086084165,-0.00023666909,0.082104124,-0.04986897,-0.041823376,-0.08291585,-0.07495894,0.026272256,0.03331353,-0.058064252,-0.0053158565,0.057742413,-0.036728922,0.019341346,0.02556968,0.09333642,0.053402115,0.0144288875,-0.013829667,-0.0150809325,0.011352459,0.018664388,-0.018480048,-0.013065933,-0.09157197,0.02548501,0.00312371,-0.049236298,-0.006726463,0.039454143,0.019034386,-0.024252843,0.060249563,-0.031469014,0.020058976,-0.0048401677,-0.0409123,-0.07727077,0.06408939,0.04106469,0.003142508,0.016818555,0.028191762,-0.112652995,-0.02036121,-0.0018095861,-0.049166575,-0.12398142,-0.0121944,-0.06220367,-0.03878499,0.0394785,-0.063645,0.032753315,-0.00086175615,-0.03445437,0.052274458,-0.0529385,0.14355557,0.02805217,-2.8129295e-33,0.093411304,0.05135772,0.012585962,0.02332073,0.06675555,-0.07581171,-0.050504025,-0.025857028,-0.00961763,0.0008451672,0.059819244,0.021473533,-0.0116213085,0.050155703,-0.025429683,0.060175292,0.01968762,-0.03132498,0.05672182,-0.013651543,0.010561527,0.10317469,-0.05936604,0.034101117,-0.032497477,-0.032503247,0.0062108543,0.09619502,0.036159594,-0.0038543348,0.045636848,-0.06531179,-0.05412721,0.0014577707,0.05798105,0.06878535,-0.056385066,-0.040623836,0.093901485,-0.0073703052,-0.030412901,0.076067664,-0.012357051,0.004985029,-0.031269364,0.05062257,-0.029946791,0.031110397,-0.008289762,0.016170518,0.032059465,-0.011084005,0.016090512,0.049033202,0.008379383,0.05160162,-0.060807787,0.02485645,0.030945009,0.018832197,-0.012959385,-0.026293175,0.042184457,-0.08254175,-0.013281482,0.0619802,-0.08178729,0.0028008688,0.028775211,-0.044089187,-0.010192433,0.02686065,0.13594605,0.053903416,0.054652713,-0.0050706947,-0.008870961,-0.0046968195,0.03362189,0.010750694,-0.0061002434,0.015118718,0.026587216,-0.04041205,-0.08265505,-0.0397036,-0.0627962,-0.118213795,-0.020514635,-0.019444928,0.006392953,-0.037501425,-0.0044947015,0.019072374,-0.018564899,-1.0872756e-33,0.038356967,-0.062945805,0.022259599,0.026986113,-0.11004387,0.032922104,-0.045982048,-0.06650566,0.0174114,0.018656611,0.07873089,0.03153838,-0.001787741,-0.060231257,0.023386698,-0.021962415,0.021724911,0.051244307,-0.02258365,-0.055903282,-0.027701331,0.07405476,-0.0157338,0.06707902,0.017582992,0.00041804786,-0.00067282096,-0.020876067,0.01870593,0.100961655,0.0069726803,0.0022198393,-0.028835751,-0.016358823,0.027591009,0.08451827,0.016766382,0.07355361,-0.12207938,-0.02954565,0.018926978,-0.017467823,0.09781873,0.07238369,0.08326144,0.059682693,-0.060000066,-0.013299744,-0.06005049,-0.022289507,-0.024530996,0.058585756,-0.07492259,0.040224463,0.021166356,0.16980033,0.1101604,-0.012927858,-0.031785667,-0.05324649,-0.04030059,-0.00123381,0.0032448808,-0.06113568,0.03869514,0.01696809,-0.1327944,0.021827435,0.097928815,-0.022125388,-0.036026288,-0.035851073,0.053394094,0.04301932,0.0078659,-0.06434854,0.027554573,-0.16243021,-0.07641143,-0.026949033,-0.0022807298,-0.029241323,0.0061738654,-0.014334041,-0.10260684,-0.025331732,0.0570452,0.04018761,-0.015054969,0.034420874,0.059081648,-0.027028834,-0.04389218,0.015472714,-0.00050584035,-2.245195e-08,0.06510896,-0.016670698,0.028814282,-0.10894743,-0.049207512,0.0020350453,0.010887275,0.019609768,0.00040395287,-0.017566169,-0.041343875,0.11932567,0.008553419,-0.012494475,-0.021058349,0.06445434,-0.03719696,0.042724364,-0.064382724,-0.007779795,-0.11733611,0.023483504,0.025944998,0.02847341,-0.006626011,-0.09193813,0.06955046,0.024090108,-0.019562945,0.029212592,0.018014597,0.038535785,-0.0033452567,-0.026666556,-0.01896924,-0.0053956243,0.060416527,-0.0453509,-0.0070195594,0.019488504,-0.040927105,-0.04394005,0.0019423292,0.038609255,0.015299784,0.0008652251,-0.01113469,0.014281318,-0.046274524,0.058687996,-0.012833504,-0.0026443093,-0.058752388,-0.064124085,-0.10356317,-0.0039909505,-0.070667684,0.027287634,0.09714262,-0.044675622,-0.04827558,0.0023719992,0.10716829,-0.00011220731 +2.7.7.44,Also acts slowly with CTP.,384,0.99999994,0.04538347,-0.08214531,0.06610473,-0.010104992,-0.021342505,-0.032602105,0.014375355,0.01052113,0.027849136,-0.026210466,0.06142485,0.007656783,-0.064040296,0.101490624,-0.007562649,-0.022360392,0.045170497,0.0036956808,0.07389995,0.026774954,-0.09950683,0.018081825,0.030204466,-0.03853691,-0.03796431,0.029972417,-0.032454044,-0.03785372,0.041546512,-0.069847524,-0.050170794,0.039976917,-0.09054284,-0.022927476,-0.047836486,0.10364187,-0.066980176,0.040488254,0.0009504895,-0.003323619,0.09898866,0.0074153133,-0.0051751663,0.019108584,0.029270535,0.009243242,-0.021437049,0.02832864,0.002148347,-0.024849975,-0.053087164,0.017679032,0.008862689,-0.0016404307,-0.06874614,-0.0056079025,0.0024666274,0.017922113,0.036105778,-0.025969665,-0.08042626,0.039437406,-0.0071220333,0.049734157,0.08515197,0.08206095,0.047960717,-0.034931537,0.005863927,0.06869509,-0.008721507,0.06893906,-0.017239012,0.020771222,-0.041605175,-0.03356761,0.003022715,-0.05925788,0.04703345,0.011135025,0.011897061,0.046926,-0.057024196,0.0025188224,0.050621156,0.0058348514,-0.0077159056,-0.06915856,-0.11938951,0.03379828,0.0038056795,0.024731321,-0.038781222,0.024015933,0.016603237,-0.01854323,-0.015035835,-0.005790652,-0.13082969,0.015186828,-0.03030323,0.064215645,0.013697764,0.0689863,-0.009954682,-0.04012256,0.06743735,-0.06252283,-0.06202292,0.051741663,-0.017269026,0.0058309045,-0.015463608,0.0112713855,0.06536485,0.09047068,-0.08591996,0.021387195,0.0048343264,-0.0043397895,-0.0009951609,-0.06715148,-0.11014647,-0.011671901,0.0061936276,0.037039828,0.049984485,-1.4221171e-33,0.008467507,-0.024138847,-0.015036828,-0.0023878147,0.027394611,0.019866899,-0.022037935,0.015518043,-0.02508102,-0.018488297,-0.032965876,-0.111866735,0.004784441,0.02331297,-0.051255554,-0.035170957,-0.012159725,0.09132301,-0.048224926,-0.05398431,0.017053857,0.08657514,-0.022735137,0.014749069,0.014000696,0.019298725,-0.10965294,0.029724192,-0.0070592556,0.006823662,-0.045294996,0.06870916,-0.07329554,0.05638846,0.0031109436,0.07202503,0.013211517,-0.04173837,0.040677313,0.028105652,-0.05866877,0.029190144,-0.061826773,0.013751038,-0.0651776,-0.057001065,-0.05969716,-0.0153252045,-0.0740537,0.06109807,0.110991016,0.027622094,-0.0012947698,-0.060577974,0.00064765726,-0.005491602,0.09179343,0.012371338,-0.022768447,0.122461185,0.076154396,0.011938703,-0.028061263,0.043354653,-0.052506838,-0.010115778,-0.04737887,-0.056737807,0.06027901,-0.01210865,-0.01145786,0.034390517,0.12465075,-0.074626766,0.05625127,-0.077009335,0.019518849,-0.040622532,-0.023683915,0.0032395993,-0.026506199,-0.09429855,0.011231468,-0.021474412,0.05064928,-0.03467433,0.042954892,-0.012310255,-0.002791196,0.031334184,0.040076844,0.04189473,-0.019114695,0.027758254,-0.0005775524,9.14006e-34,0.012312367,-0.04547509,0.037305623,0.06457854,-0.0060887774,0.020286469,-0.02755397,0.025665162,0.06340575,-0.00294349,0.117922075,-0.021590795,-0.05570286,0.040266767,0.08572608,0.03905508,0.12717411,0.046028376,0.009604494,0.032955337,0.038763665,0.064650685,-0.0020713059,0.07461865,-0.005120714,0.034452185,-0.021894509,-0.013245092,-0.011724953,-0.038232494,-0.05948636,0.07376805,-0.118608266,-0.06931777,-0.034556795,0.07886777,-0.093122296,0.04515406,-0.024868961,-0.058433983,0.13216557,0.0020268853,0.07280154,0.03608452,-0.040459916,-0.0063825413,0.09520671,-0.048961744,-0.08104961,0.12316676,0.002421407,0.045411166,-0.024021795,0.05622326,-0.0050376905,0.07031854,-0.049644824,-0.08775039,-0.070032164,-0.049587585,-0.0036698924,0.03558838,-0.060832117,-0.018752111,0.15881301,0.012950639,-0.005931918,0.0039537167,0.09510887,0.013081326,-0.0012522878,0.018413207,-0.025520552,0.013292771,-0.058775075,-0.05976617,-0.058330998,-0.033146005,0.04519648,-0.102353506,-0.021630116,0.0090575125,0.063361496,-0.048452213,-0.15666425,0.060485322,-0.075599894,-0.050429303,0.02336476,0.0595345,0.035118923,-0.018802596,0.049640637,0.014479582,-0.019657146,-1.5384611e-08,-0.014541378,0.02082736,0.025708282,-0.025243027,0.039453182,0.072403185,0.02074816,0.061688412,0.012500999,-0.006232733,0.020032095,0.05588268,0.10276686,-0.044851687,0.09640702,0.0018658323,-0.048386037,-0.010088439,-0.063984886,-0.01748659,-0.0647149,-0.0074862875,0.026105126,0.020460427,-0.10380007,0.030805849,-0.012076706,0.07847748,0.023979,-0.06620379,-0.0021618025,-0.035972178,-0.089863285,-0.029455815,0.00947722,0.040401578,0.103991136,-0.042985633,0.01389488,0.049891617,-0.06468496,-0.013716255,-0.04624002,-0.00859713,-0.08006631,-0.006956554,0.06493387,-0.10576258,0.062790394,-0.065425254,0.042766966,0.010655937,-0.028702049,-0.02844983,0.011141977,0.03559991,-0.00042504063,-0.048073575,-0.024940588,0.013226182,-0.052485857,-0.026471237,0.06255834,0.011378675 +2.7.7.45,"Also acts, more slowly, on GDP to form P1,P3-bis(5'-guanosyl) triphosphate.",384,0.99999994,-0.054372508,-0.12265989,0.008394081,0.037955597,0.066908695,-0.049384896,0.0670996,0.045942336,0.07443268,0.030463316,0.091682635,0.027565427,-0.07572852,0.06015751,0.02337739,-0.03760343,0.0009733804,-0.019439463,0.025035614,0.002873006,0.07915734,-0.015642468,0.02237939,-0.0052536423,-0.023576288,0.055697616,0.0069928,0.022997962,0.040602803,-0.09565726,-0.037173793,0.05707257,0.06323214,-0.04072435,0.030595366,0.09746055,-0.05308188,0.023147466,-0.0025368948,-0.007933515,0.099892154,-0.08214756,0.039506357,-0.03502658,-0.015094761,0.053378124,0.0042382674,0.017087348,-0.023815367,-0.04212099,-0.029564075,0.006035692,-0.08769808,0.02502739,0.0035410104,-0.055780184,-0.04036877,0.06472996,-0.022244735,-0.004521296,-0.045099244,0.003596401,-0.027103076,-0.016816998,0.15308887,0.017476266,0.05645392,-0.06208231,-0.036067117,0.068632,-0.060703486,-0.003740389,-0.05064146,-0.05993565,-0.06293862,-0.05612557,0.020465907,-0.0067549613,0.04278643,-0.08912209,0.009883473,0.036048323,-0.0011935111,-0.032660566,-0.0071537895,0.008751197,-0.042768285,-0.02664712,-0.05492411,-0.033754386,0.036233217,0.059232485,-0.0013444214,0.0061631915,-0.061074905,0.112916864,-0.04657198,-0.019851461,0.041663706,0.0007523777,0.023202157,0.12440005,-0.037319947,-0.02877192,-0.02759465,0.037870344,-0.031031419,0.016714865,0.018218571,0.12512101,-0.06998152,0.04606442,-2.4512801e-05,0.039188877,-0.04940222,0.013287921,-0.00067224074,-0.015355171,0.0024361182,0.020746944,0.08631345,-0.025851427,-0.05948224,0.048672862,-0.0605012,0.034514975,-0.03366262,-2.4016794e-34,0.0010424736,-0.019653922,0.013257235,-0.057077985,-0.08745421,0.027025802,-0.096112534,-0.060637906,-0.06541676,0.001718894,-0.059924163,-0.050145905,0.054936774,0.051316828,-0.047301684,-0.07061189,-0.066072874,0.09602353,0.11669604,-0.03901963,-0.0010497306,0.030856214,-0.025693957,-0.0108664725,0.090875946,8.7981476e-05,-0.06369551,0.018590158,0.0029149542,-0.05439562,0.1348952,-0.004691279,-0.111405864,-0.019282334,0.010871785,-0.015856938,0.025901183,-0.034219112,-0.012004075,-0.02987349,-0.028309483,-0.0003437131,-0.048655357,0.016188176,0.009311272,-0.03221585,-0.0035236217,0.033447403,0.033496093,0.011128045,0.04587615,-0.027701272,0.021921512,-0.016414296,-0.03357078,0.0012186634,0.009554165,-0.050311305,-0.004290384,0.035566278,0.030989988,0.032629427,-0.032422483,0.004624077,0.028723333,0.08477539,-0.025963824,0.024077618,0.04646636,0.086038314,-0.0022111645,-0.04098403,0.08068102,0.00868038,0.026523687,-0.032894276,-0.0046674344,-0.04286091,0.00897114,0.071314916,-0.09288462,-0.10001913,0.02652207,-0.06649552,-0.11011962,0.028422892,0.023633692,-0.09085149,0.02042525,-0.015699733,0.009412281,-0.07815009,-0.04345038,0.04356313,-0.06822256,-4.0482267e-34,0.037788108,-0.040555816,0.0049008676,0.034324482,-0.037040114,-0.007969368,0.056035753,-0.037483986,-0.00897676,0.006668758,0.07862273,-0.028087683,0.00787856,-0.049074765,0.06626051,0.093625836,0.039827645,0.06308876,0.036158454,-0.02555972,0.0073827994,0.12554191,-0.0024108775,0.12439876,-0.054842684,0.062468644,-0.046102166,-0.029207537,0.011304235,0.04311621,-0.07622929,0.022050545,-0.059840456,-0.04069531,-0.066037446,0.0044929017,-0.050070778,-0.035981797,-0.017317694,-0.021068102,0.033973314,0.07877916,0.12032637,0.046183124,0.030064214,0.07746721,0.02694116,0.05612394,-0.022839295,0.003483595,0.06215828,0.08844537,-0.10778962,0.024991982,0.03316,0.041711964,-0.008930237,-0.08290728,-0.1296726,-0.04754953,-0.0032986423,-0.056609627,0.00067979185,-0.02478949,0.07602871,0.045229502,-0.003062193,0.01066771,0.14428832,-0.0016162285,0.07093573,0.021406878,0.030140346,-0.032181166,-0.04851733,-0.009686878,0.017652737,-0.0014696226,-0.0040916284,-0.0045318813,-0.016361939,0.051688436,-0.0038046192,-0.117164895,-0.06274563,-0.06812705,-0.03387121,0.011121056,0.02104565,0.07237701,-0.1343508,-0.057353824,-0.015834805,0.08959815,0.03575225,-2.9430346e-08,0.05886903,0.0032065392,0.094269246,0.031053286,0.026098529,0.040855005,0.048521057,0.08327962,0.01900185,0.009153337,0.0050536925,0.022829983,0.060695767,-0.012998893,0.083156876,0.037308905,-0.07245922,0.03540252,-0.048930652,-0.107719295,-0.009869181,0.024067199,-0.08754524,-0.00590763,0.033562616,0.025506094,-0.016082043,0.048723757,-0.040147435,-0.030253574,0.0065404465,-0.009688428,0.020922076,-0.0044791643,0.04261937,0.0388773,0.0010299896,-0.021762343,-0.042704523,0.034505162,-0.08062177,-0.029471476,-0.064841576,0.035605248,-0.03313875,-0.0177092,-0.053376548,-0.028090259,0.04592971,-0.059633005,0.074388206,0.0013431024,-0.040910147,-0.036978144,-0.017469479,0.042557802,-0.044930547,-0.021050295,-0.0117843235,-0.022360135,0.04491566,-0.080681585,0.08782358,-0.011177295 +2.7.7.46,"ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.",384,1.0,-0.09536517,-0.021985032,-0.0342474,-0.08902313,0.053257555,-0.01589031,0.037676692,0.052071452,0.04463843,0.027399547,0.03277822,0.01857949,-0.026189847,0.13195755,-0.014373538,-0.013592001,-0.051626988,0.05396019,0.051170487,0.014001141,0.0030634908,0.047237583,0.00925978,-0.029988896,0.05349384,0.027953476,0.025372848,0.0034342716,-0.015996708,-0.026660485,-0.070442855,0.0054910206,-0.021381993,-0.01603437,0.03351352,0.11746026,-0.07341639,-0.007376744,0.050713815,-0.014242614,0.062451236,-0.038488146,0.02111852,0.053253617,-0.06442812,0.0056223506,0.008308598,0.060652453,0.035334393,-0.018031849,0.0071420874,0.03642246,0.006774014,0.07562536,0.01890278,0.084422335,-0.014751754,-0.039396383,-0.046475057,-0.04937595,-0.036247555,-0.019742994,0.008566407,0.0007318789,0.012482219,-0.054802712,0.031053467,-0.014927786,-0.019065464,-0.011419461,-0.011317288,-0.063487634,0.023402257,0.018873265,0.058885597,0.018814346,-0.02990214,-0.052917957,0.019886356,-0.016922006,-0.014988562,-0.0101939,0.10082114,0.057706602,0.060805835,-0.068869404,-0.008889,0.06292649,-0.0047974493,0.08229428,-0.0053377687,0.026879057,0.029929744,-0.059111044,-0.063438244,-0.026190298,0.03216243,-0.013834516,0.020472728,-0.015850281,0.0038693792,0.07412696,-0.019335402,-0.056834735,-0.022872277,0.030982394,-0.001822829,-0.0623002,-0.0051184804,-0.0031374062,-0.027225586,-0.01881612,0.06894333,-0.02092923,-0.030436452,0.074443996,-0.020695033,-0.076365955,-0.080976486,-0.05838489,-0.056338716,-0.07577154,0.029981492,0.031405788,-0.034453537,0.068794414,-0.026509201,5.915123e-34,-0.026262643,0.015617938,-0.043571137,0.0034283048,-0.0077920323,-0.008875904,-0.022019817,-0.06009183,-0.033645738,-0.043957938,-0.13446929,-0.070423216,0.059155174,0.06559851,-0.078378,-0.009801821,-0.05831796,0.0723655,0.039798267,-0.012468344,0.05852788,0.09020375,0.014586652,0.016741516,0.07972005,0.06125287,-0.102603644,0.03684474,0.12995644,-0.0144293485,0.045603406,-0.07428636,-0.015097552,0.03537109,-0.013994436,0.02316382,-0.003967194,-0.023673384,0.0381252,0.05066114,-0.015513068,-0.002734712,-0.03641231,-0.0008447966,0.009829238,0.020688452,0.023213807,-0.052321374,-0.06270832,0.027301429,0.08368843,-0.12560387,-0.044393387,-0.09162977,-0.028694328,-0.019853896,0.0024497001,0.02690623,0.01954055,0.014075651,-3.730756e-05,-0.0010295169,-0.0022169529,-0.003787514,0.04870967,0.056972478,-0.06072912,-0.121319175,-0.023304325,0.023799026,-0.07915464,-0.008849681,0.010033229,0.07128681,0.0373268,0.0032341601,-0.046427205,0.010625679,0.0425391,0.05410168,-0.054914944,-0.05731911,-0.034164187,-0.024636488,-0.031562585,-0.032568254,-0.0044017965,-0.095467165,0.028471287,-0.0431989,0.07399779,-0.016625043,-0.04556223,-0.04875073,0.04818108,-3.1121962e-33,0.0838869,-0.05985725,0.07989864,-0.026241494,-0.014411408,0.1055643,0.024439292,-0.1488882,0.14569587,-0.0137143545,0.046749532,-0.043270584,-0.029039506,-0.06803675,0.045462847,-0.043056443,-0.022043,0.058859263,-0.11442419,-0.036996484,-0.0014938009,0.055901617,0.03890736,0.026126364,-0.020778965,0.052374326,-0.05106284,-0.00065066887,0.115419164,0.04564689,-0.012485451,0.033746313,-0.08328616,-0.021431766,0.072027616,0.0965694,-0.06645861,0.031909883,-0.058600355,-0.029947309,0.06787286,0.03258938,0.011894331,0.109382026,-0.016379708,-0.018132105,-0.036017306,0.032442987,0.005848946,-0.10622509,0.0106945485,0.010252372,0.030713571,-0.026338866,0.07677599,0.09886329,0.090117306,-0.0589155,0.07496415,-0.08182215,-0.06685592,-0.06818401,0.02999355,0.011034708,-0.010099126,0.025993336,0.023912683,-0.015954157,0.019136695,0.0017976523,0.016976802,0.009789992,0.03403401,0.013378972,0.025202036,-0.022582967,-0.070191056,0.030621696,0.037433054,-0.06315843,-0.05301653,0.040386714,-0.0033153305,-0.037172098,0.034661762,-0.07585963,0.04199731,0.0036228735,0.02306583,-0.0361775,-0.01850144,0.055340018,0.034399945,0.023971442,0.064948246,-4.1709637e-08,0.06699729,0.0028697306,0.035633445,-0.026370628,-0.05041828,0.019305125,-0.07989786,0.016707996,0.0678968,0.014685644,0.0140526695,0.18412039,0.014802679,-0.063520744,0.051121578,0.02648775,-0.08462211,-0.025654335,-0.040232647,-0.06905234,-0.110962845,-0.0038361303,-0.09005939,0.031153554,0.019317387,0.037082918,0.0029841461,-0.01193696,-0.005334026,-0.053155895,0.053002063,-0.007025582,-0.053318765,0.028195087,0.038832467,-0.024556484,-0.016911909,-0.035626717,0.0044108694,0.04105659,0.0036204592,-0.027569076,-0.14731261,0.022394886,-0.060426265,0.08748529,-0.028286275,-0.026834717,-0.10621536,-0.013305057,0.010819405,-0.035203695,-0.032278504,-0.007580452,-0.06256372,0.029251711,-0.025828239,-0.012216033,0.009314014,-0.06524372,-0.07876314,0.029848197,0.13768548,-0.04412419 +2.7.7.47,Also acts on spectinomycin.,384,1.0,-0.028319584,-0.052634925,-0.044728063,0.010537697,-0.021309014,-0.046710923,0.074862316,0.11727125,0.047347702,0.015090647,0.04161292,0.043829814,0.042819157,0.1619008,-0.008834272,0.017997585,0.014379102,0.02156633,0.025383227,-0.024833465,0.032688424,0.067644484,0.053470768,-0.038217157,-0.030427704,-0.004446549,0.0112038,0.012266625,-0.0025021923,-0.04132045,0.019190293,0.04518642,-0.050840627,0.019759292,0.03446665,0.0030860612,-0.06468412,0.032871168,0.10438469,0.06884056,0.0554414,-0.038611785,-0.0450426,-0.03537351,0.060624693,0.018260717,-0.049041465,0.025907349,0.09068924,0.050643176,-0.06357145,-0.06368624,0.021729778,0.075988054,0.047400646,0.025985442,-0.06399437,-0.037917316,0.03877389,0.006361828,-0.05618946,-0.071827956,0.034915995,0.012859757,-0.03555554,-0.0030580605,-0.005484978,-0.02120511,0.061299708,0.0055565713,0.011731595,-0.027466642,0.025511472,0.031112362,-0.017774675,-0.032077096,-0.02304443,-0.11201026,-0.08297373,-0.038977515,0.0006191858,-0.010057057,-0.014395167,0.041050225,0.10193732,-0.024365949,0.08163554,-0.061758954,-0.06788816,0.065719776,0.046317182,-0.0040537,-0.04875202,0.015061227,-0.058274016,-0.057612315,-0.03320468,-0.0364763,-0.05799922,0.020478344,-0.07886181,-0.057348374,-0.039939687,-0.025115049,-0.060570154,0.0026407794,0.06212421,-0.0015383055,-0.049385827,0.01249142,0.026032764,0.0043851947,-0.05970338,-0.010028964,-0.0644311,0.12991652,0.13141945,0.009091052,-0.09467901,-0.024412075,-0.02045666,-0.012367413,0.00083305436,0.012057556,-0.036558256,0.028891,0.041082494,-1.8355128e-33,-0.0126062045,0.019882496,-0.051943064,0.013823366,0.06700423,0.028415248,-0.036481403,-0.023981374,-0.0038822074,-0.07301198,0.018369067,-0.04074955,0.010813299,0.047522224,-0.055032406,-0.019538514,-0.0046374034,0.017621694,-0.014224638,-0.04453475,0.06611221,0.06266059,-0.024944238,-0.016101401,-0.06676956,0.04171211,-0.038427975,0.022080509,0.03696589,-0.02543662,0.0086819045,-0.024453176,0.03298061,0.02482268,0.04879963,0.12022465,-0.023885174,-0.015071489,0.025890378,0.0239249,-0.037319046,-0.02486249,-0.06948631,0.0140097095,0.02475572,-0.031850453,-0.11135595,0.049255133,0.038495004,0.0034580596,0.041533016,-0.03881686,0.0968903,-0.050621755,-0.027118327,0.02522293,-0.0035194345,-0.0718383,0.020979255,0.032640103,0.048739176,0.019601136,-0.073535345,-0.014888106,-0.0076214694,0.02421667,-0.105287276,0.014098271,-0.094603166,0.0010914323,-0.06087996,0.045594994,0.14296134,0.029943995,0.010049648,0.016815988,-0.061063033,0.02008291,-0.018061852,-0.00951863,0.0048933914,-0.07409073,0.11792058,-0.00070980797,-0.0025908877,0.03960477,-0.017728027,-0.06104131,0.026282525,-0.030472755,0.05666597,-0.04116012,-0.07754714,-0.026543751,0.0031556522,1.6313495e-34,0.029483208,-0.026013242,0.056817804,0.04429927,0.014866806,0.058757525,-0.052922174,0.02979997,-0.016053904,-0.034796853,0.05243823,-0.06024227,-0.086447485,-0.03675108,-0.0043073064,-0.018555043,0.009012724,0.10644244,-0.07641221,0.032181576,-0.057351205,0.0013636629,0.015674852,0.05368483,0.027596176,0.08545053,0.0063991714,-0.037770767,-0.03914054,0.09091284,-0.023402624,0.0025180974,-0.11933642,-0.09762015,0.016702665,0.08497971,-0.07130567,0.0062337737,-0.0623457,-0.043395083,0.022096306,-0.09487141,0.06904807,0.065765195,0.04650416,0.072330385,0.040898837,-0.008192062,-0.07981635,-0.038606033,-0.0034783746,0.046017364,-0.0034220112,0.024341578,0.020990815,0.013948148,0.009687492,-0.08042209,0.04501419,-0.0032997516,0.020151488,-0.036709603,-0.0439367,-0.035097446,0.10287631,0.023011385,-0.011355954,0.037900645,0.14846724,-0.008239449,0.09759159,-0.007049142,-0.05275813,-0.024901044,-0.089076154,0.04903596,-0.0767303,-0.06536027,-0.00553756,0.03428941,-0.00506486,-0.066333614,-0.010458557,-0.028617779,-0.022586873,-0.008097581,-0.045625422,-0.024209205,-0.056940857,-0.007486183,-0.028192496,0.030982751,-0.03364665,0.027330939,0.016668856,-1.6942769e-08,0.023076203,-0.010729146,0.059853163,-0.027538655,0.02968966,-0.05029749,0.0451232,-0.006104116,0.076584555,-0.031663373,-0.07963034,0.094623335,0.078059055,-0.0012467459,0.046450984,-0.018364573,-0.013117371,0.04373428,-0.014041063,-0.012843606,-0.13712357,-0.03867864,-0.028450238,0.0070195277,-0.043748774,-0.03675879,0.037463285,0.131328,0.04681084,-0.044459976,0.12380665,-0.03934517,-0.037242252,0.020953251,-0.04954064,0.011907722,-0.022217035,0.011833962,0.036441628,0.022105072,-0.022313187,-0.03914509,-0.054912087,0.080541566,-0.0775208,0.0056922943,0.039623566,-0.03714544,-0.017872747,0.015808249,0.08144782,0.018506601,0.010377376,0.023157159,-0.10665679,0.023176376,0.03788438,-0.07699116,0.008384279,-0.067157894,-0.041401107,-0.08523855,0.15029925,0.08257071 +2.7.7.48,Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.,384,1.0,-0.037920848,-0.030760221,-0.00081964926,-0.0390456,0.031978223,0.017768396,-0.14928253,0.0116582755,-0.029258732,0.038682543,0.022560697,0.02546009,-0.091558024,-0.014843607,0.008267908,0.068344295,-0.20263568,0.048943922,0.05996161,-0.048179243,0.09202221,0.05737189,0.009276732,-0.0032178296,-0.033519726,0.050055154,0.082597196,-0.014913792,-0.017291872,-0.05701893,-0.0064269695,-0.06882236,-0.006419457,-0.0012455274,0.070644975,0.033044375,-0.028037198,-0.02815063,-0.019835522,0.09482676,0.101028204,0.04511233,0.0042333677,-0.04389877,-0.05294253,-0.05785735,-0.055773754,0.0014261956,-0.025171649,-0.0071963104,-0.01760628,-0.06334217,-0.04150267,-0.037228692,0.034899626,0.070483625,-0.008435462,-0.020088881,-0.0053060874,0.018803572,0.077397354,-0.058025602,-0.033032577,-0.043978184,0.11391457,-0.051459618,0.09101732,0.03462864,-0.026514929,0.025763327,-0.019804081,-0.03459853,-0.055232547,0.07481443,0.038850334,-0.036372352,0.010659441,-0.014586789,0.06684556,-0.00817598,-0.054380912,-0.029845271,0.019029416,0.020757664,-0.016642803,0.05364393,-0.027248397,0.06774745,-0.03168124,0.07507821,-0.03577051,-0.07471753,-0.00470348,-0.03878814,0.0029058082,0.07608013,0.030586543,0.05604739,0.066801794,-0.07796958,0.06758572,0.062789895,-0.09071843,-0.08955968,0.047379274,0.03349433,-0.0063378457,0.03756118,0.01829208,0.01036106,-0.01861026,-0.011753997,0.05877865,-0.06171744,-0.07264221,0.046825625,-0.020909913,-0.016570266,0.07675011,0.05890649,0.08470002,-0.041079614,-0.03309345,0.051141407,-0.05552027,-0.005747849,-0.048485726,-1.5117086e-33,-0.03796187,0.029824752,0.02238723,0.045163255,0.012947206,0.006414388,-0.08880254,0.022052985,-0.1712763,0.010232892,-0.038576774,-0.042039685,0.005051236,0.017040012,-0.05081403,-0.06437619,0.029415721,0.10186595,-0.069012225,-0.0146627845,0.04932534,0.0061429883,-0.00091456005,-0.014456963,0.03873201,-0.011257194,0.0067927297,-0.02285584,0.072935194,-0.015246753,-0.018782765,-0.032499038,-0.075952955,0.06267509,0.041305266,-0.050791062,0.0022420594,-0.07617765,0.009748329,0.1204733,0.023691807,-0.008509226,0.028726423,-0.043351077,-0.0006978633,0.028316624,0.02970367,-0.03552006,-0.04590786,0.01151538,0.07379772,-0.0021251398,0.06321287,-0.014904035,0.043544292,-0.008073808,-0.09948935,-0.00977583,0.050672866,0.027766852,-0.05266708,0.015439649,-0.05704447,0.030300893,-0.049069706,-6.0061673e-05,-0.04185436,-0.048514187,0.050869603,0.08568683,-0.057333928,-0.0049632583,0.036799908,0.039235745,0.009811408,0.008302238,-0.1090027,-0.06661103,0.039395254,0.060509205,-0.078702025,0.016294917,-0.0047948663,0.009446964,0.029800456,-0.010963836,-0.059284482,-0.062010463,-0.023844844,0.033192243,-0.038621236,-0.059550714,-0.03599307,0.06580569,0.112541005,-1.5293087e-33,0.049580082,-0.041038204,-0.008159053,-0.07412345,-0.09143728,-0.007818864,0.0001111986,-0.062554225,-0.018086774,-0.03274828,0.03687483,0.006113558,0.09871682,-0.033074994,0.0149164535,0.027572371,-0.0010749422,-0.0054583005,0.006054375,-0.03356095,0.06610619,-0.053721495,-0.033184003,0.056100287,0.06292027,0.014901322,-0.0033230104,0.09208569,0.053412113,-0.0067512584,-0.025514094,-0.066551596,0.06658708,0.04362201,-0.00049863575,0.09371466,0.024611559,0.004255555,0.06033057,0.0025632891,0.0010390237,0.03203213,0.008092414,0.056114577,0.0072447546,0.043033257,0.0036508888,0.05053854,0.029068308,-0.046950355,-0.0021736322,-0.014560251,-0.024036108,-0.00063172897,-0.014368172,-0.06643459,-0.023449328,-0.002703712,0.07466407,-0.033905707,-0.05007574,-0.040957164,0.059625942,0.0058268174,0.05485177,0.0107072955,-0.012203715,0.010536655,-0.009529726,-0.095576495,0.05582661,0.053422015,-0.015363822,0.00043440677,0.013269594,-0.032782715,-0.084214866,-0.06610784,-0.025595251,-0.068578385,-0.033114064,-0.055639517,0.021228883,-0.037177566,0.070717625,-0.056823984,0.10646093,0.10534276,-0.05240881,0.010152783,-0.011049939,0.024529768,-0.014686713,0.09275246,-0.015298652,-2.997335e-08,0.011075521,-0.069997646,0.0523245,-0.055772517,0.077622935,0.07509444,0.010582857,0.10903876,0.078294866,-0.018727574,-0.019446487,0.0012828867,0.029208655,0.0050428603,0.122782305,-0.025574466,-0.040133867,-0.037691213,-0.014445342,-0.016940843,-0.078265525,0.0557097,-0.11867261,0.036326237,-0.06880727,0.018937571,0.004287366,0.056646053,0.051545758,-0.07069517,-0.022636322,0.06138587,0.019191613,0.031808324,-0.06534041,0.009907422,0.08150971,-0.016261509,-0.042885926,0.017158914,0.020380124,-0.009073876,-0.056586787,-0.01002842,-0.079321615,-0.045745064,0.012438912,0.017877186,-0.054550797,0.0022105814,0.08639871,-0.02091141,0.03275008,-0.046102285,-0.03177216,-0.0038876173,-0.046459585,-0.043900006,-0.042160504,0.032348473,-0.014816344,-0.075918525,0.17431882,-0.012422415 +2.7.7.49,Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase.,384,0.99999994,-0.06876093,-0.016213255,-0.006228583,-0.06273061,0.026410593,0.005411987,-0.14477849,0.029623907,-0.013441469,0.024330877,0.03845663,0.037324693,-0.09145691,0.005082987,0.025043767,0.045592,-0.18071848,0.049849223,0.06925779,-0.037090816,0.10549572,0.028068652,-0.010768512,-0.0036077767,-0.037705377,0.0821922,0.05713061,-0.0053109676,0.01875506,-0.07183682,0.025207227,-0.06862259,-0.024714895,0.007920032,0.06965165,0.033116564,-0.023423474,0.013288121,-0.02842572,0.07949672,0.08337572,0.04307278,-0.040621534,-0.0021871529,-0.037559625,-0.058476835,-0.049868423,0.0058083897,-0.06586162,-0.020956395,-0.058811136,-0.041710492,-0.04063223,-0.035317495,-0.00351016,0.061563943,-0.001041811,-0.026408775,0.0073058223,-0.011436209,0.06066166,-0.046580765,-0.03524139,-0.044338983,0.11749344,-0.04173443,0.09172824,0.023879565,-0.01612518,0.037497774,0.008626379,-0.040989134,-0.041135345,0.07691071,0.035756897,-0.0137412,0.020971077,-0.031886134,0.042641018,0.011683849,-0.075228535,-0.009993548,0.014825117,0.012473261,0.0146302255,0.023365144,-0.0130408015,0.04095863,-0.04563178,0.071720935,-0.03885254,-0.06287065,-0.01566325,-0.059867218,0.012161537,0.08260632,0.054448288,0.053575195,0.06947888,-0.0676886,0.05829484,0.045419298,-0.090671316,-0.066333495,0.01764149,0.02337874,-0.015559765,0.009845111,0.05553064,0.0010167155,-0.02639561,-0.0014305967,0.04076532,-0.059655935,-0.08146537,0.00045631165,-0.03115166,-0.032318838,0.07172139,0.0589882,0.08667185,-0.038340595,-0.018124146,0.06020344,-0.0634843,-0.024964796,-0.05606794,2.5763934e-34,-0.029523902,0.038574338,0.0027108204,0.049762223,0.015219639,0.02075825,-0.084795155,0.049214914,-0.15586208,0.040626206,-0.02384622,-0.072094284,0.025757032,0.038387023,-0.039650016,-0.025746867,0.024409832,0.08325698,-0.07719471,-0.018152812,0.05581682,-0.017282583,0.0011985761,-0.016666485,0.029928228,0.015032082,0.0008654143,-0.017784508,0.046275817,-0.015674956,0.010565167,-0.081663914,-0.060371507,0.09671869,0.05155279,-0.0063185636,0.0113617815,-0.095088676,0.010906351,0.088262655,-0.004817204,-0.016204707,0.015415932,-0.0366522,0.04374403,0.006914637,0.037437245,-0.03093969,-0.10034721,0.00042011568,0.06901292,0.018598143,0.05004849,-0.030909901,0.04943993,0.006213528,-0.09437833,-0.013003701,0.039201114,0.055272657,-0.039718833,0.023460025,-0.08062142,0.0086075375,-0.014940637,-0.0065194285,-0.03931049,-0.018496718,0.05581772,0.089391924,-0.024995737,0.00604421,0.02566174,0.044591513,0.018077852,0.0024672311,-0.10414144,-0.049551807,0.04103234,0.08054305,-0.09326184,0.00741524,-0.0022976028,0.004364143,0.0075232824,0.00404739,-0.04156317,-0.023082905,-0.01309659,0.015722029,-0.017023565,-0.078734316,-0.024616776,0.023408316,0.1272984,-3.238377e-33,0.059524354,-0.045286767,-0.010644419,-0.08738375,-0.06728044,-0.015402329,0.014507303,-0.060098734,0.0048757796,-0.043052927,0.043665536,-0.014284048,0.07602716,-0.04003365,-0.014197877,0.042527337,-0.044607915,-0.019094698,0.006906263,-0.0151504595,0.04110418,-0.018054156,-0.056468513,0.088420056,0.05831485,0.008419275,-0.05018891,0.08503737,0.06534554,0.0029471463,-0.041984674,-0.041974172,0.069277726,0.026471501,-0.023555463,0.11049956,-0.028377146,0.003646552,0.034274142,0.020703403,-0.017181497,0.049475055,0.0272185,0.04675721,-0.0054971552,0.048883792,0.0054363054,0.054029312,0.043699358,-0.031592242,0.007572308,-0.0046467767,-0.045864176,-0.026209475,-0.016210085,-0.038620416,-0.014453813,-0.019433435,0.0563092,0.0021379893,-0.011924717,-0.042621344,0.078761674,0.012402786,0.045096964,-0.019104084,-0.030153424,0.0065766918,-0.016982444,-0.097176984,0.046451803,0.07654357,-0.004073188,0.020956421,0.010631469,-0.022285255,-0.09466268,-0.048824888,-0.020361966,-0.083416976,-0.02253669,-0.05013883,0.00069842156,-0.04126831,0.07276523,-0.042611867,0.0733368,0.06882805,-0.057381094,-0.018058177,-0.004971869,0.018554363,0.014836916,0.129664,0.013029573,-3.4745398e-08,-0.011162525,-0.048500706,0.047473416,-0.07818273,0.04605878,0.05723631,0.05777325,0.047345914,0.09264049,-0.044459656,-0.036518592,0.029539494,-0.011862872,0.025197979,0.120108806,-0.044974297,-0.03126466,-0.03732308,-0.015576028,-0.029801723,-0.08674357,0.03868602,-0.17525128,0.043702822,-0.03959686,0.03704646,0.03295062,0.06317126,0.04847153,-0.028418658,0.0038615428,0.057700038,0.012797919,0.031411402,-0.051929954,0.00041870924,0.08455629,-0.03890077,-0.061515484,-0.019595934,0.04810126,0.012584353,-0.080747664,-0.013718538,-0.07693767,-0.025889525,0.026762469,0.0035964155,-0.062456332,0.019416926,0.10390995,-0.055651136,0.025758766,-0.060028315,-0.03890241,-0.0020757217,-0.011358308,-0.038028058,-0.034899443,0.0038727617,0.028945493,-0.05929988,0.21247478,-0.03387111 +2.7.7.50,"The human enzyme is a multi domain protein that also has the activity of EC 3.6.1.74, mRNA 5'-phosphatase.",384,1.0,-0.048550367,-0.074857935,-0.04997635,-0.05689805,0.022205167,0.0057043834,0.00020377274,0.02582362,0.053376593,0.0011605575,0.0027775283,-0.04137702,-0.104504,0.040567417,0.047846373,-0.0043913713,-0.12773289,-0.054428264,-0.05065092,-0.04934028,0.07961307,0.06011749,-0.034610372,0.032314297,-0.02774122,-0.035204783,0.09276346,-0.0066353637,-0.03468247,-0.04218772,0.0073897834,-0.06524677,0.088198386,-0.0020854087,-0.011913295,0.0950913,-0.050848693,-0.13541445,-0.036809675,0.046224255,0.078267254,-0.014821142,-0.0041632866,-0.043523923,0.0101976935,0.04141788,-0.021782218,-0.026970845,0.15293114,0.0011701969,-0.0070763333,-0.06577818,-0.019609004,0.023859242,-0.07019952,0.053960796,-0.066812485,0.03913413,-0.014502319,-0.03532506,-0.018800069,-0.017550763,0.09273032,0.061796658,0.117072314,-0.018838298,-0.029344123,-0.0491873,-0.09210323,0.052857134,-0.05731873,-0.10402766,0.015094246,0.047682356,0.051386457,0.012322512,-0.014879192,-0.065840855,0.056903612,-0.038532164,-0.0032839011,-0.038023375,-0.018684775,0.021906199,-0.0068666693,0.04241946,-0.034256242,0.0053074765,-0.039794214,0.046392664,0.008753589,-0.100224294,0.052496873,0.025107877,-0.028084513,0.062493954,-0.04839336,0.11195977,0.011278353,-0.03757547,-0.020894853,0.094537355,-0.02951965,-0.064743765,0.0067807734,0.024976026,0.031004047,0.09453593,-0.026853103,-0.018126884,-0.004973818,-0.041200254,0.03456104,0.008989347,0.07586499,0.01513758,-0.017934682,-0.0898284,-0.007949593,-0.02919691,0.039101083,-0.04994312,0.025470674,0.041254804,-0.01085522,0.0048562256,-0.09283825,-3.4536105e-33,0.017976247,-0.042058725,0.058379978,-0.011829105,-0.04459123,0.06852917,-0.06804939,0.0113167595,-0.06863208,-0.0401318,0.014437776,-0.025729725,0.07690286,0.028326688,-0.012221885,-0.021091387,0.0046344586,0.06439915,0.04350092,0.022220133,0.0744029,-0.022037072,-0.06080113,0.07468946,0.02165693,0.052881584,-0.0696686,0.0038497348,0.023766773,0.0044484604,-0.09107596,-0.019488702,-0.08584266,0.012026426,-0.0019066829,-0.017679282,0.03431911,0.0012516517,-0.045424722,0.043709002,0.032784425,-0.046260912,-0.016532514,-0.02276173,0.0554051,-0.016226118,-0.086794406,0.09692221,0.028228091,-0.005857585,0.014610153,-0.06026159,0.13431425,-0.078241535,0.009513514,0.003698246,-0.10316019,0.0075379424,-0.0012120194,0.047613483,-0.028613687,0.10228474,-0.05000379,0.09214052,-0.024910733,0.018794717,-0.0456521,-0.11026996,0.0045471354,0.14541513,-0.0038446959,0.015303385,0.037073195,0.04483283,-0.0020903687,-0.022870123,-0.01890692,-0.016996946,-0.045686062,0.122630514,-0.03895418,-0.07234603,-0.015136632,0.0033365712,0.0014875915,0.0036859522,0.048227128,-0.038263954,-0.015780011,0.031131322,0.07429011,-0.045197807,-0.05730362,0.050818603,-0.04610314,5.6298993e-34,0.053152155,-0.071105644,0.03275341,-0.06847846,-0.008437318,0.08200636,0.11701921,-0.009405473,0.019109441,-0.010173574,0.060280453,-0.026150392,0.0566422,-0.08486813,0.0831419,0.016074315,-0.06678654,-0.014639819,0.072032556,0.018563729,-0.021156875,0.037166137,-0.02838248,0.08000331,0.030324887,0.036310945,-0.08507129,0.052960984,-0.0038645822,-0.0012143612,-0.09862201,-0.012234154,-0.018218372,-0.028783098,-0.019807914,0.0048995186,-0.042566102,-0.022777136,0.079017244,-0.030973813,0.00974362,0.09561913,0.0046518855,0.020291748,0.015065379,0.100875914,-0.03068047,0.08172199,-0.070359096,0.006169003,-0.012659858,-0.018639725,5.7270878e-05,0.019933918,-0.027016075,-0.0054684007,0.01856954,0.053734675,0.031182384,-0.01435946,-0.040894177,-0.061602943,0.026069984,0.07791478,0.0025330284,0.00975434,-0.0004175092,-0.0038522477,-0.036009714,-0.034531184,0.06852016,-0.04571394,0.01460783,-0.005570433,0.015432668,-0.048488777,-0.0934659,0.016776452,0.052660357,-0.0044535603,-0.01216035,0.0048464676,0.00737441,-0.010384943,0.036413487,-0.012326306,0.018808892,0.11717846,0.03072036,0.048396707,-0.06430897,-0.029043596,-0.119348474,-0.003346443,-0.012284703,-2.9709932e-08,0.066540554,-0.028967662,0.07149231,-0.09204134,0.04334179,0.00047415725,-0.0022352189,0.03255349,0.04214437,0.06010158,0.011106849,-0.0056873476,-0.01338683,0.014293799,0.07126697,-0.030561643,-0.06715529,0.06359163,0.001067074,-0.028740332,0.008441436,0.019077985,-0.102848485,0.022788,0.011988937,0.0065164203,0.02700875,0.03090449,-0.072181515,-0.05587739,-0.014920359,-0.0006374603,0.0025745728,-0.0026679158,-0.06483619,-0.015421298,0.02986706,-0.016564788,-0.078884386,0.07178628,-0.052669056,-0.058997042,-0.01612123,-0.030094206,-0.017059611,0.013017028,0.06518683,0.021439308,0.007642659,-0.05254128,-0.007309134,-0.05612662,-0.021338562,-0.024222266,-0.065671586,-0.063422136,-0.034538593,-0.10093203,0.010909939,-0.041821305,0.050760947,0.06420907,0.1709903,-0.030649299 +2.7.7.52,The enzyme requires an oligoribonucleotide or polyribonucleotide with a free terminal 3'-OH as a primer.,384,1.0,-0.0345298,-0.08485372,-0.0820815,-0.05183556,0.021076562,-0.03187917,-0.11115165,0.04967347,0.020524735,0.03970242,0.0038045542,-0.03704864,-0.123198554,0.051270157,0.016180817,0.04828834,-0.09184234,0.002687647,0.034042757,-0.061258953,0.104285054,0.032191303,0.036851685,0.019056913,-0.002146226,-0.028373599,0.09017371,-0.007834449,0.051469985,-0.050601818,0.0032960495,-0.08751028,0.045710623,-0.04590396,0.058722027,0.02742085,-0.077734336,-0.03768503,-0.024385257,0.07182777,0.15375364,0.0066227918,-0.030455142,-0.0010737407,-0.047554746,-0.049515672,-0.029109525,0.032125555,0.06593907,0.048910033,-0.040348798,-0.06254554,-0.062747896,-0.0030912603,-0.065462776,0.023443831,-0.032169297,-0.052438818,-0.046820648,0.029957933,-0.05428352,0.0067852503,-0.004441375,0.00013948504,0.112078965,-0.018668152,0.041161563,-0.040050276,-0.054417294,0.01055019,-0.021796515,-0.014647133,-0.014144248,0.018194376,0.014575519,-0.027610624,0.028072646,-0.003706835,0.05264206,0.025123289,-0.00422924,-0.002157643,-0.02802595,0.12205446,0.032409202,0.046155065,0.0044552237,0.01730934,-0.029347062,0.033877917,-0.01385622,-0.04368484,-0.049982954,-0.061753735,0.0017325359,0.024167106,0.05396795,0.022903364,-0.00396915,-0.0069163954,0.031240076,0.051963724,0.011240566,-0.04132529,-0.10236173,0.06742766,-0.00029997964,0.046907753,0.01739823,0.05562433,0.025387019,-0.01801703,0.118031174,-0.0134172235,-0.07911557,0.051020317,-0.0809058,-0.10935937,0.028225264,0.041051507,0.048721224,-0.02023382,-0.014108641,0.07365582,-0.058808107,0.04369622,-0.03199812,2.3478369e-33,0.04072928,0.09534409,0.012177624,-0.041843984,-0.03422964,0.05250143,-0.08870235,0.010134451,-0.14323565,0.01181381,-0.035084333,-0.11991247,0.06396403,0.020314226,0.014048883,-0.018809048,0.040399846,0.0008964567,0.023077035,0.0028858285,0.02582675,-0.013347349,-0.075703785,0.05204395,0.016899241,0.05922043,-0.016459296,0.011073196,0.07282833,-0.007584913,0.059803348,-0.078278996,-0.083537556,0.021905359,0.052729394,-0.048700206,-0.020738205,-0.07294024,0.0040545925,0.038853418,-0.0287724,0.030439898,0.027982637,-0.0125928465,0.1025339,-0.121170156,-0.0014014657,0.058856618,0.0042614895,0.053188175,0.06376408,-0.012050559,0.06480181,-0.0062917983,0.008595944,-0.0008795174,-0.043520227,0.021458056,0.04343523,0.03864824,-0.026604012,0.047715135,-0.034103382,0.07910229,-0.018659815,0.04469926,-0.09287454,-0.022736512,-0.0038591202,0.11460602,-0.019917317,-0.016563253,-0.01881693,0.014526851,-0.02355462,-0.032277137,-0.04795513,0.0025513426,0.0241882,-0.009040853,-0.013988281,-0.0424257,-0.023337735,0.04611231,-0.06048484,-0.03482992,0.03825604,0.039386265,-0.02168551,0.022353405,0.12818016,-0.094939895,-0.069105916,0.023313154,0.060520157,-4.1609554e-33,0.08323957,-0.07590889,0.034905225,-0.05622413,-0.04842917,0.042738315,0.014967119,-0.044617455,0.02310696,-0.060829453,0.048389424,0.017179064,0.008135001,-0.065968744,0.07253258,0.03722551,-0.088899136,0.07090022,-0.0234011,0.022628225,0.0466349,0.08495069,-0.010467015,0.032832246,0.023228306,-0.016104182,-0.057294875,0.07507941,-0.026705952,0.0639236,-0.11937815,0.002244977,-0.029392155,-0.058109272,-0.044949196,0.05100384,0.023184136,-0.026476957,-0.024743829,0.030235063,-0.033127762,0.071665585,0.020953408,0.07701317,-0.010254771,0.0950935,-0.041132703,-0.016264623,0.076539144,-0.012944064,-0.026195709,-0.008349962,-0.023036247,-0.020322122,0.013033569,-0.004910589,-0.003652976,-0.010787403,-0.00029320686,-0.06700739,-0.0348077,-0.045741037,0.060999323,0.0064340206,0.039678,-0.010299461,-0.04809784,0.063915126,0.01647122,-0.009587589,0.010332578,0.08688428,0.055435542,0.04431382,0.008431065,0.011894885,-0.123464294,0.027339414,-0.0010170449,-0.04544385,0.024360433,-0.0269601,-0.009564105,-0.048952386,0.014016486,-0.07593104,0.09753339,0.07196411,-0.03977267,0.030974653,0.016613059,0.0010371313,-0.015862975,0.042661436,0.056719437,-3.3877715e-08,0.023493694,-0.041100323,0.022053631,-0.064515516,0.00909206,0.06330676,0.04260133,-0.037353583,0.010491829,0.02074892,-0.0030434423,0.07426465,-0.030821607,0.04549748,0.10946307,-0.042846065,-0.010810726,0.01534484,-0.0415552,-0.064056225,-0.151519,0.015551593,-0.109857336,0.016879346,-0.008976321,-0.03160772,0.026468283,0.05482933,-0.008130878,0.024093742,-0.014133523,0.018948628,-0.016341709,-0.09236992,-0.07457938,0.05847645,-0.020210112,0.0031882685,-0.024407176,-0.019784676,0.018707724,0.01562891,-0.08407156,-0.043558687,-0.04256571,-0.020878682,0.032851513,-0.016344719,-0.038223505,-0.0029686803,0.026773207,-0.10310198,-0.01017316,-0.05023949,-0.05887215,-0.039049964,-0.029925272,-0.060983952,-0.036710206,-0.054964233,0.060846314,0.018021928,0.19055249,-0.043951113 +2.7.7.53,GTP and adenosine tetraphosphate can also act as adenylyl acceptors.,384,1.0,-0.05479247,-0.043021355,-0.00564148,-0.019238187,-0.006498506,0.012874017,0.051582374,-0.006225086,0.09915563,0.05303145,0.06427513,0.00453477,-0.06496032,0.11402877,0.04747709,0.027757062,-0.021466827,-0.018949995,0.072714664,-0.033011965,-0.003904383,0.031152429,-0.027190799,0.020610202,-0.011993614,-0.013947344,0.025143955,0.071689494,0.020110918,-0.007500155,-0.083545506,-0.031908136,-0.03250143,0.005423691,0.03447104,0.13220759,-0.09267705,-0.037804656,-0.015712753,-0.017362077,0.03234854,-0.03900282,-0.02829057,0.041650888,-0.015066267,-0.027708692,0.021664163,0.050768413,-0.016800841,-0.019466795,0.03461789,-0.043076113,-0.02034075,-0.031933546,-0.015303801,0.070729256,-0.13145043,0.005888762,0.016160682,-0.0059942654,-0.010383167,-0.042015597,-0.013979909,0.006959435,0.085204184,-0.010191378,0.042645335,-0.029299656,-0.024700748,0.009078971,-0.023562662,-0.011356892,0.02318593,0.022066507,-0.017647346,0.026391245,-0.029842038,-0.027048051,0.041519374,0.004519772,0.06471128,0.04604534,0.065707475,0.025011787,0.084442556,-0.055900782,-0.014840986,0.047726706,-0.056742214,0.012772034,0.0012229087,-0.027678054,0.09537528,-0.012997638,0.020748291,-0.050028805,0.04424391,-0.07328538,-0.026067087,-0.035322707,-0.041635726,0.06793087,-0.040596332,-0.029368786,-0.03855939,0.045831017,-0.083276354,-0.0011626391,-0.011946885,0.011380317,-0.05682537,-0.0040318444,0.041134953,-0.0020192289,-0.01319453,0.08331947,-0.1072394,-0.027354125,-0.0020304965,-0.01462554,-0.1025461,-0.06125824,-0.051851165,0.07139971,-0.03691146,0.056554146,-0.012294501,2.6291153e-33,0.06115208,0.028662283,0.011687606,-0.043725904,0.040037695,0.025954979,-0.017006414,-0.0073439344,-0.0187144,-0.020508941,-0.0700376,-0.06683607,0.06579792,0.01922464,-0.0076171723,0.045724742,-0.14875972,0.10101043,0.03705689,-0.052701555,-0.0443003,0.08732573,-0.014376295,-0.014027375,-0.05319006,0.063359536,-0.1574775,-0.025468517,0.10006277,-0.019189972,0.022642715,-0.008779273,-0.10456398,0.084271014,-0.026916653,-0.038948067,-0.06772285,-0.08823063,0.046040926,0.026144357,-0.039886158,0.017667843,-0.02546927,-0.043489106,-0.00010260987,-0.04621479,0.02420513,-0.03849771,-0.025857823,0.056227032,0.047559045,-0.00407598,-0.043185323,-0.07619053,-0.055344816,-0.00041549993,-0.02102898,0.020198155,-0.020245835,0.024003614,0.04376792,0.03572167,0.038206704,-0.049264256,-0.03436801,0.0381165,-0.11764783,-0.116231754,0.04013497,0.11770963,0.044588234,0.033490997,0.06824812,0.010046072,0.038793113,-0.017866962,-0.016657807,0.026022054,-0.012096486,0.039253317,-0.061504163,-0.084208734,0.01832972,-0.0017879067,-0.039590985,-0.03664439,0.06708728,-0.09330203,0.0426511,0.049793977,-0.0043858234,-0.025418194,-0.048215095,-0.0014906458,0.021116188,-4.2384036e-33,0.09318397,-0.028402584,0.010540139,-0.056256745,-0.047438245,0.042080205,-0.0021261661,-0.16263357,0.07095253,-0.015691238,0.10446535,0.062155493,0.035411462,-0.013671101,0.00697448,-0.05046799,-0.0029135353,0.06430888,-0.074607335,-0.033862222,0.0032524816,0.00068646745,0.02498173,0.075182185,0.05349364,-0.005315236,-0.00396623,-0.036506735,0.07962203,0.058361363,-0.03765295,0.06933424,-0.12161276,0.00516684,0.08628253,-0.009702663,-0.047499087,0.020888867,-0.012160041,0.030253321,0.06487615,0.08986964,0.059816267,0.073191985,-0.0141785,0.08270632,0.045786686,0.013807228,-0.050539102,-0.08522536,0.0041975453,0.016680358,-0.035374206,0.03571088,0.031875394,0.14811455,0.04723013,-0.072022386,-0.057047915,-0.061076008,-0.049087632,-0.061188936,0.021610878,-0.069644116,0.02477581,-0.021945203,-0.022601338,-0.0045982827,0.079290606,0.013616811,0.021995297,0.019570326,0.058771875,0.025478462,-0.014352359,-0.009828957,0.006872678,-0.07571494,0.05296124,-0.11036737,-0.024469368,0.106979884,0.01684773,-0.054977905,0.012450104,0.03701838,-0.022765992,0.06799526,0.04219633,0.053397465,0.015366284,0.023074483,0.03757448,0.043266688,0.048135974,-2.3986903e-08,0.043915268,-0.028166397,0.05326196,-0.076649055,-0.027154058,0.03617788,0.025592057,0.051305976,0.015530771,-0.038253013,0.02182806,0.0447577,0.013590757,-0.0032016486,0.02448167,0.01761617,-0.03811614,-0.03446127,-0.034307975,-0.10114785,-0.16423102,-0.03247945,-0.040901657,0.07901001,-0.016467992,0.049815517,0.01064191,0.04490849,0.00599557,0.0066547026,0.051460132,-0.036337025,-0.031607777,-0.034043033,0.05351561,0.010337914,0.04472383,-0.0027793504,-0.09824508,0.013740187,0.018792799,-0.09908343,-0.04258402,0.0326631,-0.0085935285,0.02858482,0.01671163,-0.0026887418,-0.051595304,0.042949393,0.034324955,-0.03419061,-0.011544668,0.009576558,-0.027883071,-0.04559462,-0.04886784,-0.048762556,-0.012174866,-0.058690105,-0.037719272,0.037158065,0.1338231,-0.06407433 +2.7.7.54,Part of the system for biosynthesis of the alkaloid cyclopeptine in Penicillium cyclopium.,384,1.0,-0.070462234,-0.012631386,-0.07463958,-0.0025663131,-0.0467994,0.0054183058,-0.014388621,0.027105121,0.07734645,-0.05305673,0.021732783,-0.049900323,0.07807113,-0.013604962,-0.09105129,0.027876735,-0.026367329,0.02445126,0.0027192677,-0.025616165,0.03208476,0.09597343,0.0057526776,-0.011053432,0.026569096,0.028407859,-0.06726853,0.0016950993,-0.048027467,-0.01830097,0.03470917,0.045891456,-0.0048008105,-0.11818812,0.12176494,0.038191486,-0.11625499,0.06308473,0.09633891,0.039286934,0.02806142,0.040889055,-0.04221821,0.059198268,-0.030292757,0.038216583,0.0075231763,0.063483834,-0.010837764,0.0041125375,0.013191198,-0.0013556802,0.003369311,0.09438609,-0.003781003,0.050377015,-0.057207596,0.05358681,-0.007102681,-0.0028205763,0.015370773,0.023119751,-0.025856717,0.031086197,-0.054717705,-0.028065236,0.011797143,-0.096702226,0.039807394,-0.0545864,-0.031831976,-0.00672051,0.01727849,0.00945043,0.038238216,0.08325445,-0.028589835,-0.04008981,-0.11247877,-0.04032347,0.05958205,0.042598873,-0.030443847,0.10121691,0.03140482,-0.0436715,0.05198661,0.026217788,-0.0020334586,0.0040938454,0.05758241,0.025433268,0.0004990396,-0.05088514,-0.04726461,0.024649765,0.03825852,0.029892154,-0.041842848,-0.03145249,0.0625335,-0.023545783,-0.0587687,-0.0220417,-0.03177279,-0.025597287,-0.03102383,0.015622522,-0.07359923,-0.07940152,0.01821727,-0.044784177,-0.0146638015,-0.061383415,0.047127694,0.01209138,0.019066945,5.243412e-05,-0.009564069,0.07029056,-0.014950774,-0.0012247687,0.0066995574,0.053259242,-0.012671253,0.0815691,-0.045990337,5.5652178e-34,-0.018410943,0.037000995,-0.0060797124,-0.04371989,0.018393561,-0.014367977,-0.009939757,-0.055789094,-0.00611958,-0.063139744,-0.08294459,-0.040865377,0.016086655,-0.017578742,-0.024584927,0.06508226,-0.058563773,0.026260206,0.0667999,-0.0090538645,0.037676994,0.034908336,-0.07551161,0.023460165,-0.061092492,0.09168267,0.028247338,-0.015534987,-0.010812706,-0.026402913,-0.037566457,-0.049618047,-0.052182797,-0.041458253,0.082654454,-0.004508524,0.047851227,-0.06714923,-0.017894572,0.052448854,-0.07152044,0.04480293,0.029169869,0.0063985297,0.07659218,0.048076224,-0.10171486,0.07059482,-0.0029196667,0.003931334,0.063204296,-0.034581956,0.141163,0.027460335,-0.09395893,0.015619622,-0.038973145,-0.015642531,0.00765587,0.026866956,-0.07147662,0.03926585,-0.041797236,-0.011023339,-0.042472452,0.006987764,-0.03721521,-0.070474364,-0.021731926,0.011503535,-0.07044094,-0.048335124,0.029970571,0.059027415,0.046608888,0.020863459,-0.015307745,0.014872233,-0.02071374,0.023069542,0.030104063,0.011128592,0.013206473,-0.04887909,0.031284638,-0.07515973,-0.036957487,-0.046203848,-0.012930033,0.06650667,-0.0020660688,0.008843405,-0.069088645,0.065965846,-0.03930258,-1.699175e-33,0.06773212,-0.039057177,0.027206209,-0.004577546,-0.027505957,0.04799586,-0.12669028,-0.018899651,0.034736585,-0.0018276923,-0.0013126668,0.0071763955,-0.0017018174,0.078532584,-0.078093216,-0.06891364,0.064890034,0.19310437,0.044051476,0.027345207,-0.09156403,-0.0100674005,-0.011742961,-0.038665093,0.05967888,0.0050170277,-0.012209034,0.029638002,0.0075213304,0.06511597,0.005779855,0.04291626,-0.042850003,0.02046166,-0.030274922,0.14156245,-0.01795402,-0.048645273,0.05084038,0.1121664,-0.049471024,-0.024965348,0.059827182,-0.0029908177,0.07323915,-0.03924716,0.025596058,0.062891,-0.05160395,-0.00056748406,0.09042571,0.0034463864,0.015214662,0.00080949505,0.06358061,0.026112117,0.03215864,0.020004874,0.09538521,-0.0011161894,0.024189556,-0.054875962,-0.009166894,0.025446488,-0.010961039,0.098182596,0.032552145,0.11349542,0.015582658,0.014855881,0.006418528,0.028583055,0.037899606,0.023460675,0.025345525,0.08449425,-0.026470887,-0.03280748,0.030976374,-0.0147078,-0.028562045,-0.012804894,0.075601615,-0.071338356,-0.044879705,-0.04532106,0.038218196,0.106998764,-0.02746462,-0.0080096945,-0.031206094,-0.002285216,-0.002932303,0.061862197,0.0605362,-2.2366683e-08,0.090111755,0.012619537,0.012093001,0.0055731623,0.0054102642,-0.013654477,0.01938611,-0.064786345,0.05030726,-0.062370997,-0.011793726,-0.0059688343,0.013458772,0.026158493,0.0049438756,0.07897648,-0.018124413,-0.025936961,0.0077353134,0.065677404,-0.04099589,0.0009935845,-0.07670622,-0.04934545,0.014567637,-0.15697184,0.055757165,-0.019201899,0.012611009,0.04380928,0.036344297,-0.059577793,-0.07260979,-0.100941405,0.0071514924,-0.004182227,-0.105505064,-0.040293798,0.055191603,-0.055157132,-0.10031678,-0.050384853,-0.07523054,-0.022001075,0.016484132,-0.04333893,-0.014750187,-0.024932278,-0.068104245,-0.047951374,-0.053074766,-0.040471677,0.025647474,-0.07011209,-0.013886124,-0.008169937,0.04267359,-0.05675465,-0.051463805,-0.1289167,-0.15135434,0.06136397,0.1412538,0.015159826 +2.7.7.55,Part of the system for biosynthesis of the alkaloid cyclopeptine in Penicillium cyclopium.,384,1.0,-0.070462234,-0.012631386,-0.07463958,-0.0025663131,-0.0467994,0.0054183058,-0.014388621,0.027105121,0.07734645,-0.05305673,0.021732783,-0.049900323,0.07807113,-0.013604962,-0.09105129,0.027876735,-0.026367329,0.02445126,0.0027192677,-0.025616165,0.03208476,0.09597343,0.0057526776,-0.011053432,0.026569096,0.028407859,-0.06726853,0.0016950993,-0.048027467,-0.01830097,0.03470917,0.045891456,-0.0048008105,-0.11818812,0.12176494,0.038191486,-0.11625499,0.06308473,0.09633891,0.039286934,0.02806142,0.040889055,-0.04221821,0.059198268,-0.030292757,0.038216583,0.0075231763,0.063483834,-0.010837764,0.0041125375,0.013191198,-0.0013556802,0.003369311,0.09438609,-0.003781003,0.050377015,-0.057207596,0.05358681,-0.007102681,-0.0028205763,0.015370773,0.023119751,-0.025856717,0.031086197,-0.054717705,-0.028065236,0.011797143,-0.096702226,0.039807394,-0.0545864,-0.031831976,-0.00672051,0.01727849,0.00945043,0.038238216,0.08325445,-0.028589835,-0.04008981,-0.11247877,-0.04032347,0.05958205,0.042598873,-0.030443847,0.10121691,0.03140482,-0.0436715,0.05198661,0.026217788,-0.0020334586,0.0040938454,0.05758241,0.025433268,0.0004990396,-0.05088514,-0.04726461,0.024649765,0.03825852,0.029892154,-0.041842848,-0.03145249,0.0625335,-0.023545783,-0.0587687,-0.0220417,-0.03177279,-0.025597287,-0.03102383,0.015622522,-0.07359923,-0.07940152,0.01821727,-0.044784177,-0.0146638015,-0.061383415,0.047127694,0.01209138,0.019066945,5.243412e-05,-0.009564069,0.07029056,-0.014950774,-0.0012247687,0.0066995574,0.053259242,-0.012671253,0.0815691,-0.045990337,5.5652178e-34,-0.018410943,0.037000995,-0.0060797124,-0.04371989,0.018393561,-0.014367977,-0.009939757,-0.055789094,-0.00611958,-0.063139744,-0.08294459,-0.040865377,0.016086655,-0.017578742,-0.024584927,0.06508226,-0.058563773,0.026260206,0.0667999,-0.0090538645,0.037676994,0.034908336,-0.07551161,0.023460165,-0.061092492,0.09168267,0.028247338,-0.015534987,-0.010812706,-0.026402913,-0.037566457,-0.049618047,-0.052182797,-0.041458253,0.082654454,-0.004508524,0.047851227,-0.06714923,-0.017894572,0.052448854,-0.07152044,0.04480293,0.029169869,0.0063985297,0.07659218,0.048076224,-0.10171486,0.07059482,-0.0029196667,0.003931334,0.063204296,-0.034581956,0.141163,0.027460335,-0.09395893,0.015619622,-0.038973145,-0.015642531,0.00765587,0.026866956,-0.07147662,0.03926585,-0.041797236,-0.011023339,-0.042472452,0.006987764,-0.03721521,-0.070474364,-0.021731926,0.011503535,-0.07044094,-0.048335124,0.029970571,0.059027415,0.046608888,0.020863459,-0.015307745,0.014872233,-0.02071374,0.023069542,0.030104063,0.011128592,0.013206473,-0.04887909,0.031284638,-0.07515973,-0.036957487,-0.046203848,-0.012930033,0.06650667,-0.0020660688,0.008843405,-0.069088645,0.065965846,-0.03930258,-1.699175e-33,0.06773212,-0.039057177,0.027206209,-0.004577546,-0.027505957,0.04799586,-0.12669028,-0.018899651,0.034736585,-0.0018276923,-0.0013126668,0.0071763955,-0.0017018174,0.078532584,-0.078093216,-0.06891364,0.064890034,0.19310437,0.044051476,0.027345207,-0.09156403,-0.0100674005,-0.011742961,-0.038665093,0.05967888,0.0050170277,-0.012209034,0.029638002,0.0075213304,0.06511597,0.005779855,0.04291626,-0.042850003,0.02046166,-0.030274922,0.14156245,-0.01795402,-0.048645273,0.05084038,0.1121664,-0.049471024,-0.024965348,0.059827182,-0.0029908177,0.07323915,-0.03924716,0.025596058,0.062891,-0.05160395,-0.00056748406,0.09042571,0.0034463864,0.015214662,0.00080949505,0.06358061,0.026112117,0.03215864,0.020004874,0.09538521,-0.0011161894,0.024189556,-0.054875962,-0.009166894,0.025446488,-0.010961039,0.098182596,0.032552145,0.11349542,0.015582658,0.014855881,0.006418528,0.028583055,0.037899606,0.023460675,0.025345525,0.08449425,-0.026470887,-0.03280748,0.030976374,-0.0147078,-0.028562045,-0.012804894,0.075601615,-0.071338356,-0.044879705,-0.04532106,0.038218196,0.106998764,-0.02746462,-0.0080096945,-0.031206094,-0.002285216,-0.002932303,0.061862197,0.0605362,-2.2366683e-08,0.090111755,0.012619537,0.012093001,0.0055731623,0.0054102642,-0.013654477,0.01938611,-0.064786345,0.05030726,-0.062370997,-0.011793726,-0.0059688343,0.013458772,0.026158493,0.0049438756,0.07897648,-0.018124413,-0.025936961,0.0077353134,0.065677404,-0.04099589,0.0009935845,-0.07670622,-0.04934545,0.014567637,-0.15697184,0.055757165,-0.019201899,0.012611009,0.04380928,0.036344297,-0.059577793,-0.07260979,-0.100941405,0.0071514924,-0.004182227,-0.105505064,-0.040293798,0.055191603,-0.055157132,-0.10031678,-0.050384853,-0.07523054,-0.022001075,0.016484132,-0.04333893,-0.014750187,-0.024932278,-0.068104245,-0.047951374,-0.053074766,-0.040471677,0.025647474,-0.07011209,-0.013886124,-0.008169937,0.04267359,-0.05675465,-0.051463805,-0.1289167,-0.15135434,0.06136397,0.1412538,0.015159826 +2.7.7.56,"Brings about the final exonucleolytic trimming of the 3'-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3'-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase.",384,1.0,-0.049258668,-0.061936945,-0.099833965,-0.0585289,-0.026910815,-0.036907393,-0.020488622,0.055301692,0.03257492,0.018182226,0.08543955,-0.035273664,-0.094198234,0.05396325,-0.042789973,-0.028988533,-0.12160995,0.029746165,0.06284424,-0.054839294,0.054548826,0.07907084,-0.03694507,0.04529082,0.015705211,-0.03384324,0.07556797,-0.06867599,0.006260882,-0.027501674,-0.054127786,-0.05332424,0.055363126,-0.10057878,0.12462337,0.062293693,-0.02290736,-0.012502603,0.1117258,0.002618725,0.059120595,-0.0014873896,0.04372399,-0.005643738,-0.040280886,-0.019240815,0.028417554,0.061928295,0.0015860788,-0.0010930051,0.025496727,-0.032122396,-0.011839059,-0.013117879,0.031521544,0.050749313,-0.067824595,-0.059556436,-0.003614648,0.06603181,-0.002662893,-0.010580826,-0.0026866854,-0.046784315,0.085975856,-0.06630033,0.12078035,-0.052610416,0.020739192,0.021960393,-0.060546264,0.0045819096,-0.01869219,0.08108738,-0.03142724,0.0634961,0.047665883,0.0017176874,-0.027769852,0.014060915,0.029794041,-0.1038317,-0.0008198496,0.0023307,-0.032340907,0.0108164,-0.06548066,0.027769798,-0.006789563,0.12424434,0.022545956,0.0034869444,0.03494397,-0.049064748,-0.007719654,0.080356784,-0.03320646,0.05187148,0.042719007,-0.027526503,-0.0012030118,0.05854253,-0.006749422,-0.015177811,0.0038209294,-0.015838116,0.041698895,0.03790159,-0.07234403,0.031236703,0.0092962375,-0.022760505,0.06643997,-0.024852904,-0.03227669,0.061331727,0.015787903,-0.056216963,0.045613497,0.032370694,-0.001434988,-0.016595596,0.020378167,0.08854162,-0.03698199,0.017918615,-0.024897031,4.8490927e-33,0.020593869,0.051404826,0.03345789,-0.019789005,-0.016954815,-0.0070723956,-0.08675849,-0.06319967,-0.09906644,-0.03654053,-0.05561917,-0.06315821,0.0746209,-0.066157766,0.019185679,-0.03156047,-0.02070051,0.072104216,-0.004155837,0.014374308,0.022178616,0.036943886,0.0121328365,0.014744134,0.055044457,0.0190731,-0.099959284,0.01574206,0.03559081,-0.0112827495,0.019877879,-0.022866238,-0.07031522,-0.0019657493,0.09432865,-0.07725017,-0.014786717,-0.04354634,-0.07322874,0.09378409,0.003690152,0.04224278,0.008988208,0.024225336,-0.002532461,-0.026578294,-0.006268221,0.0046584313,0.009193175,0.045793954,0.016168907,-0.0026826214,0.08864399,-0.03870894,0.013919485,-0.08387593,-0.005187711,-0.047584347,0.08824384,0.019613624,-0.020736804,0.08886477,-0.07927123,0.01693116,-0.046651084,-0.025167434,-0.039193988,-0.054358006,0.006784721,0.043718375,-0.040728197,-0.07805949,0.059811227,-0.02040152,0.05779415,-0.020350061,-0.10847075,-0.023913607,-0.032469057,-0.033764962,0.05043446,0.015609545,0.0411557,-0.048791252,0.01708231,0.02191986,0.013250274,-0.037220508,0.0036658752,0.050571438,0.0068763345,-0.045287956,-0.07134661,0.056648403,0.016603837,-5.442201e-33,0.1041931,-0.032981347,-0.009987228,-0.08442457,-0.12342798,0.013378017,-0.023153815,-0.04790267,-0.014720169,-0.057558484,0.047604177,0.00066108804,-0.018273639,-0.010972188,0.019905167,-0.046419047,0.08160139,-0.003114257,-0.010820986,-0.06648432,0.072098374,-0.025236292,-0.024999265,0.021810893,0.034910936,-0.030732676,-0.004141518,0.07860502,-0.026222842,0.022664206,-0.11287093,-0.049842194,0.06867217,0.05120143,-0.08893476,0.027190212,-0.0076087983,0.030213611,0.11419855,-0.021519655,0.011637452,0.043793194,0.029656732,0.031666026,-0.056343194,0.09517616,0.011143662,0.053249713,-0.065214545,-0.048215028,0.05413615,0.03908645,0.022801666,0.007627531,0.024323363,-0.015845925,-0.011704008,0.04108129,0.017416589,-0.010799099,0.0070205755,-0.1072734,0.005992756,-0.0436203,0.09178034,0.008403028,-0.038471576,0.13245022,-0.02502835,-0.026494753,-0.07869213,0.05208761,-0.036080904,0.01154568,-0.0031537386,-0.05868914,-0.04542568,-0.06458046,0.06696262,-0.055626195,-0.0811828,-0.031836145,0.0023033281,-0.063324906,0.106398486,-0.08291613,0.03211046,0.08920521,-0.012703789,0.0450247,0.015957111,-0.022436623,0.012140053,0.04109487,0.017364712,-3.7128466e-08,0.014150303,-0.022778612,-0.043475807,-0.010805329,0.090175934,0.07381439,-0.03526949,0.053481262,0.073605694,0.006009849,-0.008229974,0.008277137,0.029348718,0.028771477,0.111955665,0.037759237,-0.10776077,-0.032400426,-0.012865694,-0.004473636,-0.066881314,0.04005756,-0.16190033,-0.004158578,-0.008240268,0.023131793,0.036467522,0.033871345,-0.038970917,-0.031458296,0.012635782,-0.023012744,-0.015871821,-0.044459075,-0.04818563,0.015937176,-0.01095158,-0.03663414,-0.043818057,0.08049585,-0.006146127,0.025238367,-0.088631056,0.047378954,-0.057215244,0.027706617,-0.051035605,0.084727556,-0.058420308,-0.017512659,0.08823567,-0.076066904,0.023246283,-0.016648555,-0.032470077,-0.06945695,0.0028812399,-0.061102197,-0.07827389,0.06834402,0.077409,0.0017488025,0.13444121,0.017237665 +2.7.7.59,"The enzyme uridylylates and de-uridylylates the small trimeric protein PII. The enzymes from Escherichia coli and Salmonella typhimurium have been wrongly identified, in some databases, as EC 2.7.7.12 (UDP-glucose---hexose-1-phosphate uridylyltransferase), from which it differs greatly in both reaction catalysed and sequence.",384,1.0,-0.0653237,0.030157514,-0.05323942,-0.05826841,-0.019283269,0.020972036,-0.052701324,0.06062044,0.08626436,-0.019056851,0.05720938,0.013146884,-0.07374658,0.05872892,-0.060139067,-0.04461994,-0.062068168,0.049415585,-0.024675202,-0.07814391,0.11541177,0.04723425,-0.027181227,-0.016679978,-0.002773823,-0.04318541,0.10008526,-0.02744768,-0.03349069,-0.05360586,-0.00085749995,-0.04649973,0.07907735,-0.102057435,0.13539223,0.10181624,0.02261927,-0.13747242,0.15366004,-0.037462614,0.07265753,0.010288521,0.02221054,-0.040680878,-0.03181725,-0.015921505,-0.031581003,0.047966775,0.046647903,-0.03785342,-0.085068464,-0.0035373822,0.008629156,-0.0140483705,0.058441274,-0.04915863,-0.09661613,-0.052486766,-0.01983198,-0.029734055,-0.028037252,-0.056963578,0.038045205,-0.026009679,-0.024006035,-0.063492276,0.05767649,-0.11846781,0.0360805,-0.07698672,-0.04684629,0.019000703,-0.06008762,0.089653395,-0.010417274,0.014212037,-0.076356165,-0.012594596,-0.044651404,0.0064848172,-0.009813407,-0.06883358,0.045426775,0.08679056,0.040437184,-0.03159472,0.044516515,0.0720381,0.020429563,0.04524248,0.022000927,0.025194105,0.050499186,-0.017521579,0.0065330463,-0.042892765,-0.022513645,0.0043248455,-0.020823084,-0.015476225,0.0068845986,-0.0019635004,0.038428314,-0.083315745,-0.044147056,0.029422525,-0.005969219,0.08624273,0.0502888,0.002419537,-0.017051341,-0.02162123,0.050139956,0.015584088,-0.06896074,0.06876873,-0.0026232856,-0.0890235,-0.016568908,0.0044908114,-0.00021843049,-0.02957806,-8.314232e-05,0.11175281,-0.044268884,0.08245166,-0.11150179,1.9159223e-33,0.06123026,0.11148384,-0.023918664,-0.06622915,-0.05636528,-0.0035219358,-0.034395233,-0.032561492,-0.05604987,-0.08558654,-0.09623369,0.003070051,0.034813743,-0.022900676,-0.021035006,-0.004877255,0.033635378,0.10535524,0.033596344,0.009252696,0.014003907,0.10108862,0.0617651,-0.06289816,0.0930954,0.009937474,-0.01679171,-0.07720083,0.00865958,-0.008047521,-0.005808468,-0.053636678,-0.042310856,0.00383999,0.11591882,0.013581837,0.04077006,-0.026879143,-0.05147026,0.05253246,-0.012133447,0.03174561,0.010973662,0.00907876,0.011539398,-0.09032948,-0.03240041,-0.018209042,-0.013550697,0.07554319,-0.022962973,0.009271181,0.11018541,-0.023433357,-0.08337437,-0.09062926,0.021739192,-0.058331065,0.036957745,0.05506309,-0.0037563604,0.10770336,-0.018478477,0.0023465792,0.0076649357,-0.047612168,-0.03862086,-0.013119709,0.0061462885,0.13272408,-0.049442217,-0.02264907,0.06738468,0.0043873186,0.0786494,-0.10765569,-0.064234436,-0.022192376,0.0461414,0.036545902,-0.004575305,0.0065338938,0.020968772,-0.036379457,-0.09516003,0.034721058,0.00417057,0.024277816,-0.001165104,-0.012941931,0.02374799,-0.036903646,-0.07469078,0.07969044,0.007711897,-2.8514541e-33,0.043502826,-0.07582368,0.03842717,-0.05811407,-0.09403149,0.013256304,0.015118652,-0.00024900652,0.07772268,0.024745885,0.10903257,-0.035615824,0.04227168,-0.04213386,0.04715448,0.06540384,0.04539016,0.011956635,-0.018459272,-0.03639737,-0.0530795,0.03942218,-0.042469863,0.049841575,-0.009809844,0.03999377,0.06605389,-0.027550148,0.0054013664,-0.04328688,-0.006634512,0.008578458,-0.08525228,-0.057204284,-0.01858127,0.075056314,-0.038666088,0.043342527,0.05261169,-0.029019805,0.010643224,-0.0015930495,0.025597448,0.063210234,-0.015750133,0.010278626,-0.00786318,0.09790877,-0.11279071,-0.011367765,0.00066407106,0.010706878,0.050236877,-0.020630198,0.017620262,0.0003770671,0.020098194,0.073092505,-0.10158141,-0.003796518,-0.00069154275,-0.026785724,0.05611686,0.041743092,0.012187751,0.052900422,-0.012375771,-0.024097426,0.028210964,0.0064179464,0.009651846,0.010353255,0.043254767,0.051817134,0.048486575,-0.038938466,-0.11054325,0.005373638,0.06352241,-0.027026167,0.021452148,-0.0415111,-0.019879775,-0.08298296,0.06787984,-0.0438556,0.01978899,0.049999524,-0.010761294,0.06803921,-0.033959765,-0.013030769,-0.031460367,0.057965428,-0.0068632313,-3.821354e-08,0.08065277,-0.013170046,-0.034229234,0.0081940945,-0.040702406,0.032084208,0.011365882,0.048010055,0.057616584,-0.003397401,0.016193982,0.04177392,-0.018734729,-0.045009173,0.019110488,0.058390863,-0.05282535,0.0076137823,0.016378442,0.046436016,-0.015352923,0.018211655,-0.08277697,-0.0012912799,0.021396909,-0.070545994,0.023898428,0.014220716,-0.08199472,-0.07257034,-0.0037343537,0.019002387,-0.042300586,-0.042057462,0.019555496,0.043472584,0.02496943,-0.0135532925,0.0041307234,0.03980582,0.038920682,-0.039873168,-0.10492919,-0.021072684,0.024686445,0.030188642,0.0070152325,-0.027009651,0.0025782268,-0.021697015,0.054411113,-0.022795206,0.0041479566,-0.02654612,-0.065525204,0.04505385,0.01013586,-0.12053044,0.0050856033,-0.037923306,0.051074643,0.0044916756,0.13459332,-0.004247442 +2.7.7.60,"The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).",384,1.0,-0.028035138,-0.07094083,-0.014352608,-0.011444088,-0.051021285,-0.0038436225,-0.05973568,0.04983876,0.015662406,-0.009533801,0.030300012,-0.024366233,-0.0421069,0.06634158,0.006914273,-0.028701566,0.04513033,0.03379821,0.10985832,-0.006338879,0.05165067,0.08063025,-0.046927504,-0.07275782,0.011749984,0.024726162,0.041393623,-0.011342702,0.055965163,-0.027570872,-0.15995114,0.04250157,-0.049294505,-0.11465524,0.06971663,0.10129054,-0.08248377,-0.017289912,0.052453123,-0.066885665,0.072514765,0.005970403,0.021871148,-0.018814664,0.041511074,-0.054601274,0.019717531,0.019680895,-0.046919405,-0.06641946,-0.002659388,0.018508371,0.018369092,0.029711792,-0.03384762,-0.026121143,-0.008993041,-0.06817231,-0.0529291,-0.024587812,-0.034849413,0.0045168097,-0.0044594267,-0.0285957,0.054216035,-0.0037279513,0.00071552536,0.014769318,0.030975284,0.0028159586,-0.088241875,-0.046345126,-0.035504483,0.03328291,-0.06821002,0.020914994,0.07265034,-0.017421264,0.05499651,0.017728318,0.041037768,0.026004555,0.05035228,0.1022898,0.11405346,-0.010856796,0.017265286,0.04415694,0.010944762,0.11073086,0.016317679,0.06896182,0.061097164,-0.026834982,-0.048898775,0.022672107,-0.030682493,-0.038452744,-0.04956003,-0.050766543,-0.012381148,0.09570564,-0.027092442,-0.000775249,-0.03872677,0.004794402,-0.021600485,0.024282185,0.014690331,-0.016351167,0.05985422,0.031876285,0.006326907,-0.025313126,-0.0031698407,0.014011704,-0.04581448,-0.11734843,0.020207735,0.022155942,-0.040225167,-0.067392,-0.062394146,0.08276248,-0.06936952,-0.015146814,-0.009809542,4.589944e-33,0.046476766,0.0844077,-0.011004002,-0.084362276,0.023320546,0.030784559,-0.044233147,-0.04439558,-0.01880498,-0.072653025,-0.08501232,-0.072349735,-0.0018294237,-0.0017739899,0.020094968,-0.039730564,-0.05061963,0.10480987,0.11327223,-0.04652204,-0.044289608,0.10250957,0.000517645,-0.044368394,0.050999526,0.097304635,-0.07774733,-0.029956322,-0.0014760685,-0.011044436,0.01176103,-0.055384256,-0.038695555,0.050393973,0.07942915,-0.05014147,-0.035805695,-0.038422722,-0.024056755,0.06855491,-0.038904212,0.09331138,-0.023263896,0.0190281,0.054936107,-0.10033083,-0.0009975849,0.001366376,-0.034309857,0.045075946,0.041299522,0.041366614,0.000147948,-0.07161552,-0.05718753,-0.030095177,0.005585418,0.05913467,0.008973654,0.077103816,0.01770707,0.037477937,-0.028638033,0.04562991,-0.016325157,0.0625776,-0.090816006,-0.113931336,0.014391165,0.09934145,-0.04177105,-0.019234922,0.10928571,0.0028348316,0.070844926,-0.02744479,-0.038494978,0.017808272,0.034761224,0.030681677,-0.02577526,-0.04342133,-0.05778125,-0.060746033,-0.012331697,-0.02776139,0.031809833,0.011676269,0.049270455,0.04121427,0.07830938,0.024731949,-0.05992627,0.051583245,0.002190656,-5.422316e-33,0.041517653,-0.052813094,0.034273848,-0.093480766,-0.114186555,0.011042994,-0.010602132,-0.12670942,0.06863202,0.0054017915,0.04929704,0.010166764,0.03613475,-0.022926653,-0.06486868,-0.038560864,0.032341737,0.08802805,-0.07657548,-0.08347923,0.06877155,0.06835953,-0.0044965474,0.06523326,0.009264993,0.015726725,-0.003912689,0.036192495,0.020620786,0.053168766,0.007355565,0.032534406,-0.04192531,0.010760869,-0.016710214,0.103014156,0.0039025405,0.06528412,0.018422417,0.048757683,0.055763237,0.013466685,0.0016374392,0.068819486,-0.041561786,0.020566536,-0.08915713,-0.021157427,0.06609381,-0.05253198,0.07241468,-0.013468501,-0.03525066,-0.032473918,-0.01766379,-0.017875446,0.0013703936,-0.041947417,0.011588378,-0.061461706,-0.015449739,-0.051658727,0.01850679,-0.06874081,0.06646338,0.026104234,0.001576941,0.028662313,0.009021675,0.03688485,-0.019453354,0.10953956,0.06922133,-0.040655077,0.010671444,0.032539047,-0.039133195,-0.073569946,0.04460968,-0.060813706,0.006624143,0.081716575,-0.024708888,-0.04368049,-0.033193838,-0.015327094,0.0011216226,0.07417455,0.037243832,0.060794283,-0.003944631,-0.018783022,-0.01958887,0.06369157,0.005444568,-4.059416e-08,0.02223953,-0.05765078,-0.004777357,-0.027230702,-0.029781008,0.050785247,-0.048015077,-0.056404475,0.10355605,-0.0046429415,-0.02546432,0.06333163,-0.001446798,-0.012709062,0.105661735,0.00525033,-0.026496748,-0.06154556,-0.03516597,-0.11712039,-0.053142946,-0.010052804,-0.09225466,0.046145972,0.026298732,-0.045303676,-0.023393117,-0.02484905,0.008625481,-0.058149822,0.023624083,-0.01545355,-0.05413372,0.016352674,-0.029122202,0.010650551,0.0006632743,-0.06287945,-0.0709394,0.035902735,-0.010976667,-0.0278604,-0.09446779,0.026718406,-0.026557257,0.051604588,0.001699053,0.003579088,-0.06863155,-0.001122055,0.040935766,-0.06319715,-0.011440256,-0.030589977,-0.046015404,-0.0127646625,0.048406325,-0.044742946,-0.07592571,-0.032815233,0.009717998,0.039540343,0.19967425,-0.05086574 +2.7.7.61,"The gamma-subunit of EC 4.1.3.6, citrate (pro-3S) lyase, serves as an acyl-carrier protein (ACP) and contains the cofactor 2'-(5-triphosphoribosyl)-3'-dephospho-CoA [1,3]. Synthesis and attachment of the cofactor requires the concerted action of this enzyme and EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase [1]. In the enzyme from Escherichia coli, the cofactor is attached to serine-14 of the ACP via a phosphodiester bond.",384,1.0,-0.039930344,-0.06685436,-0.09407349,-0.061685313,0.09139567,0.0875104,-0.017356902,0.095689856,0.05642709,-0.0066910093,0.13327423,-0.07877799,-0.0762615,0.043447275,0.03383507,0.011333095,-0.028412808,-0.04013557,-0.0061655478,-0.12980242,0.015798558,0.019377004,-0.056675117,0.012696206,0.009786745,-0.016379962,0.042950094,-0.09253946,-0.03101556,-0.051625106,-0.048019964,-0.044846773,-0.036816586,-0.03446153,0.06879051,0.029341087,-0.0033091055,-0.16151138,0.029194754,0.01952762,0.053942222,0.053771,-0.014986172,-0.027341671,-0.023029989,-0.037920114,-0.015316483,0.02878888,0.072461486,-0.043036707,-0.030725623,-0.029222071,-0.0007595282,0.060862616,-0.06160609,0.072343275,-0.035630208,-0.11015457,0.000822721,0.022309892,-0.027404642,0.026767781,0.063692205,0.006086957,-0.022005994,-0.057514716,0.05383517,-0.055607837,-0.013567246,0.020882834,-0.08589596,-0.061738756,-0.005609037,0.037804756,0.019929135,0.052739944,-0.011028249,-0.037983797,0.03562873,0.010052696,-0.012671818,0.012294711,0.07950856,0.02646212,-0.0014325505,-0.08278068,0.023916071,-0.0019329998,0.009041188,-0.00734521,0.017984673,-0.06788347,0.009685447,0.0064103077,-0.05852381,0.08889389,0.0040279212,0.0022396818,-0.007575259,-0.018810024,-0.00786929,0.10317581,0.027972091,-0.041348763,-0.06815991,0.0012356107,0.0054882998,0.11507182,0.01479497,0.018645711,0.04563466,-0.06985548,0.03689071,-0.05567364,-0.021816874,0.09049511,-0.02502081,-0.049677253,0.043356173,0.0045360136,0.07021685,-0.044299986,0.015159201,0.060760017,-0.031832974,0.068546556,-0.15171297,5.0509022e-34,0.08391446,0.06681867,0.06881694,0.01048742,-0.0030153373,-0.047408827,-0.10833986,0.025047746,-0.04309184,-0.065693356,-0.07540283,-0.028679842,0.036450777,-0.008159707,-0.010414986,-0.02928814,-0.028210772,0.0062856292,0.060337774,0.037617706,0.01789526,0.061926033,0.04202191,-0.013466724,0.051111113,0.03917703,-0.075779654,0.0027873623,-0.02399735,0.034782246,-0.031661626,0.010217849,-0.05370135,0.06865453,0.05845406,-0.03561102,-0.036378395,-0.08162137,-0.014698342,0.05574067,0.09183367,0.03268356,-0.028555032,-0.049413614,0.06954882,-0.06193996,-0.049612235,0.011040646,0.013699025,0.09027954,0.0026493769,-0.0016651799,0.07367414,-0.008528455,-0.05564874,0.010206927,-0.049523562,-0.0027590932,0.08677089,-0.024281688,-0.03538133,0.095443405,-0.040614583,0.01928111,-0.016782422,0.034900066,-0.07665163,-0.042093586,-0.0061997673,0.04500374,-0.08143715,-0.013720318,0.014497892,0.021352144,0.042473763,-0.12516204,-0.07379038,0.06318727,-0.015947506,0.09504838,0.02720552,0.0044178856,0.001223462,-0.012750335,-2.7076401e-05,-0.048288733,-0.0026621856,0.03641075,0.020550396,-0.0022472695,0.06924517,0.028719109,0.050435934,0.09090587,-0.0155366715,-2.5083935e-33,0.10112302,-0.13952449,0.030841723,-0.10195016,-0.08132369,0.044085708,0.03918077,-0.010955618,0.04740981,-0.019603424,0.061064247,0.058912296,0.003303861,-0.10969228,0.019009458,-0.0036704428,0.0006238796,0.046163287,0.0009034714,-0.00892878,0.053966723,0.013098772,0.086898066,0.011411458,0.08670327,-0.020577235,0.031325813,0.018199094,0.0015773412,-0.02043253,-0.0059194746,-0.018864915,-0.020891953,-0.06711019,-0.12726659,-0.039289802,-0.06708823,0.047425807,0.055286773,0.010517413,0.021135181,0.07698464,0.09039588,-0.003313021,0.007916189,0.08491164,-0.015923513,-0.02328797,0.0044805,-0.04599664,-0.030837746,-0.081375144,-0.053619932,-0.039883498,-0.034479275,0.069872424,-0.014674057,0.06479926,-0.02487124,0.012997666,-0.0442289,-0.01740464,0.037004177,0.015069463,0.08714034,0.05529039,-0.042103,0.020105029,0.06932741,-0.006147761,-0.0028405439,0.058890484,-0.009346775,-0.013521548,0.044455282,-0.059772994,-0.09687875,-0.006366656,0.026636517,-0.04840952,-0.022650389,-0.040595178,-0.022391707,-0.03780198,-0.0046538133,-0.04500889,0.006067436,0.120447345,0.01373193,0.019338882,-0.037197284,-0.024989111,0.008416541,0.08635469,0.06136388,-4.1434177e-08,0.016485063,-0.0003999073,0.0035378195,-0.054560922,0.013607667,0.043508455,0.017088026,-0.056364227,0.06972752,-0.020350965,0.029326601,0.051962968,0.031256206,0.017277705,0.0022990773,0.0246054,-0.024490362,0.043356765,0.016213158,0.007562744,-0.015472107,-0.040793575,-0.0063884608,0.072818264,0.015005735,0.0033867909,0.05349564,0.032149732,-0.03560387,-0.022635816,-0.11141892,0.014600378,-0.04378692,0.0012976904,-0.023016775,-0.054130092,-0.03328956,-0.07157762,-0.02259736,0.04462248,0.049973257,0.04712223,-0.066216104,-0.013220855,0.053975858,0.03451435,0.04260858,0.027230762,-0.079297975,-0.033847887,0.030183136,-0.06025618,-0.04428585,-0.017041111,-0.06580609,-0.08164054,0.009777306,-0.11478209,-0.03280633,-0.060773183,0.020051904,-0.018364469,0.14743015,-0.009320731 +2.7.7.62,"In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nuclotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC 2.7.8.26, cobalamin synthase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62) activities. However, both activities are not required at all times.The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin [4]. The guanylyltransferase reaction is a two-stage reaction with formation of a CobU-GMP intermediate [1]. Guanylylation takes place at histidine-46.",384,1.0,0.012527447,-0.03481079,-0.13285479,-0.051379025,-0.03207145,0.030239658,-0.010281625,0.018195426,0.05803438,0.017893804,0.0074937413,-0.031972356,-0.03499484,0.0370633,-0.0078091286,0.03128663,-0.07138887,0.032352682,-0.021049855,-0.068807684,0.017484317,0.07026896,0.030803522,0.005702188,-0.037685562,-0.00090344885,0.021640591,0.043119267,-0.005064747,-0.056818433,0.012832656,-0.03207546,0.089689314,-0.057473913,0.07806745,0.0855229,0.0020669654,-0.07851521,0.060855262,0.043416336,0.056156777,0.06071217,0.027681248,0.029873317,-0.033180166,0.022493245,-0.015409988,0.07817538,0.018489929,0.0026839608,-0.033342384,-0.03581317,-0.05082523,-0.038212836,0.014652999,0.09186987,-0.078085855,-0.049316395,0.04216596,-0.03804936,-0.0015958414,-0.049296867,0.015489467,0.059559062,0.033843454,-0.028076995,0.06475519,-0.07294941,0.026524609,-0.0034191783,-0.034823023,-0.04447756,-0.04877376,-0.014090494,-0.03715962,0.06953755,0.03744302,-0.043878235,0.0041293544,-0.059533708,-0.039600432,0.020054454,0.0409874,0.0005020046,0.023680013,-0.0459588,0.010650179,0.04214276,0.050488383,0.07708282,0.03949232,0.0034944052,0.12374825,-0.06290737,0.0037191946,-0.025811136,0.10128234,0.08113919,0.019644402,-0.06359865,0.0023571816,0.04471227,-0.042499516,-0.047885202,0.07284176,-0.043030206,0.050737515,0.12600687,0.021005973,0.03711562,-0.058480803,0.053946447,0.062202696,-0.02645127,0.0020502869,0.047781475,0.0084905615,-0.004054084,-0.014676244,-0.0037941453,0.0028685129,-0.06622759,0.027334414,0.0129990475,-0.016620087,0.021017265,-0.06437999,4.8134664e-33,0.05080592,0.034768306,0.0348144,0.014675549,-0.016712015,-0.02808173,-0.071085654,-0.028789902,-0.049310315,0.02891432,-0.06852985,-0.015150183,0.05969326,0.006442767,-0.030659031,-0.072816625,-0.06363478,0.016677337,0.020655883,0.11017197,0.002355956,0.032028064,0.014810384,0.06973821,-0.0028159553,0.015307032,-0.031683467,0.077385046,-0.02454583,0.0017295445,-0.05442212,-0.008594453,-0.14158477,-0.009130383,0.051310997,-0.066281,-0.05976585,-0.008850723,0.028873648,0.09967663,-0.04711306,-0.010417805,-0.06971144,-0.008170448,0.05200087,-0.06277086,-0.0045302804,0.08946515,0.022907486,0.043853097,0.0036646172,-0.008485958,0.08138104,-0.01780142,-0.028190318,-0.027226541,0.0026498116,0.0022471524,0.031987198,0.09284783,0.009620836,0.07153793,-0.039735813,0.056232203,-0.03139598,0.02064002,-0.02509766,-0.13090688,0.00033789474,-0.0039234133,0.03800718,-0.038225554,0.059829168,0.070847504,-0.0064984807,-0.0014841236,-0.033800874,-0.1279338,-0.017311605,-0.032842197,-0.0009565462,0.01391845,0.046003804,-0.036537543,-0.010457486,0.01617908,-0.0076368228,-0.042707376,-0.08315065,0.009131723,0.035016038,-0.03299531,-0.016749687,-0.015862608,0.057094906,-4.8736642e-33,0.1503777,-0.07336138,0.005016658,-0.14158253,-0.095628075,0.031514917,0.038520627,-0.117627375,0.089930445,-0.08936064,0.08099863,0.020536905,-0.013819716,-0.011846849,-0.03319144,-0.061311137,0.031839445,0.106744476,-0.049354173,-0.041723426,0.040990938,-0.0053088884,-0.040627975,-0.009033465,-0.031543236,0.029043542,-0.00378609,0.07817242,0.045708645,0.051039584,-0.048798293,0.050610006,-0.050372932,0.005062736,-0.03709085,0.06710966,-0.017809682,-0.0017428135,0.021488912,-0.025352016,-0.009544801,0.07286334,-0.03399705,0.02214528,0.039111603,0.07709511,-0.015319523,0.00020961446,-0.06296162,0.005059502,0.015314576,-0.0069092507,0.012919332,0.038869042,-0.014109078,0.06715404,-0.013762108,-0.060332876,0.04388636,-0.0825069,-0.0017133779,0.017607985,0.06572067,-0.04477146,0.009861552,0.03084163,0.038920775,0.05039827,0.03471042,0.027388636,-0.029509103,0.04977087,0.03082454,-0.0032817652,-0.048433878,0.017952293,-0.06817893,-0.081513554,0.020839231,-0.091642626,-0.043465972,0.04139179,0.0020518731,0.008168086,-0.019171625,0.0029202423,0.03372723,0.049576793,-0.05016261,0.057243776,-0.041937646,-0.080687866,0.030408895,0.08537248,0.042850584,-4.9189463e-08,0.051801436,-0.044883266,0.00148736,-0.06786999,0.078934304,0.10163735,-0.07759624,-0.04881867,0.13765138,-0.064731754,0.0074572894,0.108825624,0.010283881,0.04444137,-0.052277125,0.08229777,-0.045720346,-0.06685526,0.018450668,-0.09553436,-0.08306019,-0.027704053,-0.073307574,0.050024617,0.03710983,-0.06162703,0.026220905,0.08862678,0.011098753,-0.034673158,-0.02469495,-0.03126907,-0.04720538,-0.0376344,0.04636545,-0.016213678,-0.04865824,-0.016303092,-0.0033381865,-0.009367909,0.004363248,-0.016732525,-0.095159814,0.03197054,0.015727162,0.03031363,-0.07677753,0.07406516,-0.04582212,-0.056344505,0.041768644,0.03534137,-0.044360165,-0.0106328735,-0.06654018,0.03804224,-0.03350413,-0.084925205,-0.027640129,0.01764003,-0.052799005,0.009202141,0.07199368,-0.16295357 +2.7.8.2,1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately.,384,0.99999994,-0.055054963,-0.09009607,-0.053873,0.051486913,0.0027730172,-0.006831574,0.059781116,-0.009878567,0.033783436,-0.042867497,0.097134456,-0.024515588,-0.05359955,0.07387697,0.015226182,0.08871696,-0.019970879,-0.056794316,0.015152315,-0.020494282,-0.0035262718,0.07278434,0.04123285,-0.0024717285,-0.023782963,-0.05898976,-0.019790076,0.009240628,0.017908856,-0.05665517,0.04662572,-0.07000858,0.021520227,0.01812338,-0.011675723,-0.006236829,-0.053291675,-0.0076158466,-0.027633192,0.052412927,0.06939844,-0.11105035,-0.029175512,0.016360957,-0.023516342,-0.03645897,-0.039583247,0.01865653,0.00032533798,0.025857817,0.0017815946,0.004636244,-0.027770123,0.06876174,-0.03383942,0.011756276,-0.12315677,0.03977259,-0.051314138,-0.04860142,-0.017103847,-0.022129308,-0.044651665,0.016279198,-0.11648079,-0.029710976,-0.009383128,-0.08069772,0.06056065,0.0448118,-0.02637245,-0.079907134,0.06985455,0.004024149,0.034013942,-0.036753636,-0.042033903,-0.077140376,0.056261424,-0.0009891806,-0.0077752536,-0.049007162,0.01711433,0.06487944,0.013109239,0.024637923,-0.060319968,0.021932423,-0.028953029,0.014529242,0.019861665,-0.056241263,0.046987977,-0.037756648,0.021506054,-0.06589688,0.05621824,-0.05964475,-0.000921957,0.03275712,-0.04632268,0.011744901,-0.024572702,-0.061564263,-0.042395346,0.029076349,-0.020557202,-0.07185615,0.011263858,-0.014866563,-0.04086575,-0.10222852,0.10950505,0.0022051523,-0.05952846,0.06288174,0.009092344,-0.041788615,0.038886663,-0.04788679,-0.06501417,-0.0594985,0.02955975,-0.01797745,-0.016163802,0.06925391,-0.022882229,2.9807483e-35,-0.019349722,0.011315916,-0.048768353,-0.019265123,-0.017472845,-0.0067858333,-0.064974464,-0.007094217,-0.022598196,-0.03640665,0.0076936367,0.0108783245,0.021927424,0.12211417,-0.026482262,-0.042496376,0.01957678,0.09068596,0.099419124,-0.089556724,0.0122114215,0.04626795,-0.04197854,-0.036928784,-0.033954624,0.021836106,0.0078204945,0.01875725,0.054479774,-0.03283024,0.04168289,0.023984298,-0.046617452,0.027427983,-0.0036745064,0.06512195,0.014167463,0.00063486793,0.021899363,-0.101178445,-0.010547271,0.024121018,-0.03765039,-0.0016006246,0.064208075,-0.008374407,-0.122082025,0.038880266,0.056280483,0.00049328565,0.045683473,0.004343004,0.018630138,0.012180501,-0.020828849,-0.028122256,-0.02960591,0.04910769,0.024973772,-0.008778995,-0.014277006,0.08732452,-0.022262393,-0.07866508,-0.059759263,0.0074398154,-0.03859357,-0.06797791,-0.067143805,0.003481228,-0.0073116524,0.03698038,0.0320675,0.03861077,0.027561862,-0.0023061044,0.01706733,-0.00073372223,-0.009368612,0.022482527,-0.056609213,-0.050994348,0.05990056,0.09417095,-0.07700016,-0.022239108,-0.020097835,-0.074545965,0.024396576,-0.032815497,-0.03442661,0.02428895,-0.052485287,0.08664988,0.097451806,-2.1192279e-33,0.036909662,-0.048715137,0.068721406,0.0014521035,0.05174526,0.075137936,0.052513774,-0.038685456,0.15677428,0.005514043,0.10798194,0.06260804,0.017898427,-0.040284865,0.04618669,0.012581164,-0.052934274,0.06759085,-0.029442886,0.03597343,-0.037196115,0.061876655,-0.0014441351,0.10561796,0.025285939,0.06386343,-0.0033480078,-0.02115027,-0.005980911,0.05523873,0.01902254,0.012500504,-0.0049107205,-0.07585443,-0.02919889,0.0046249633,-0.08240288,0.05851184,-0.12081759,0.033461895,0.063580595,-0.031609457,0.031019803,0.067619964,0.04262485,0.0008476737,0.03325837,-0.047822837,-0.0469017,-0.089453526,-0.040021762,0.060241766,-0.022516299,0.036572345,0.13201126,0.21341324,0.058192775,-0.082256645,-0.016331641,-0.06526107,-0.037980624,-0.012356088,0.03663626,-0.019233245,0.07529918,-0.0015237761,0.020155761,0.0149989715,0.07357981,-0.018520901,0.11264766,0.068019815,0.021292534,0.036656644,0.044969123,-0.0076266574,-0.010885055,-0.10609349,-0.08244966,-0.047744326,-0.047503874,0.043731857,0.042860065,-0.06512159,-0.04056157,-0.008945174,-0.050161142,-0.033971723,-0.04013406,0.08540221,0.01392166,0.017469384,-0.03139945,-0.016114444,-0.012403434,-2.979508e-08,-0.037750628,-0.012578939,0.053709354,-0.0856912,-0.10309549,-0.0031551989,0.03223312,0.033301834,-0.034560595,-0.08911055,-0.024130298,0.107509635,0.09508093,-0.0087227505,0.06606148,-0.011473453,-0.0004983092,0.05353262,-0.047546905,-0.08216858,-0.057301667,-0.015897164,0.03437566,-0.027335376,-0.06270175,-0.021078547,-0.018454807,0.055390745,-0.016996635,0.043085515,0.017127909,-0.005510244,-0.0008839844,0.009610054,0.08436891,0.07688177,0.022997236,-0.04567644,-0.116260625,0.10003705,0.042149473,-0.03991147,-0.035676833,0.04127612,0.021399148,-0.012816714,0.009091306,-0.07051088,-0.028568693,0.01594603,0.05139307,0.00962461,0.00923202,-0.037292544,-0.08305249,-0.0041105286,-0.09629167,-0.028524501,-0.010474903,-0.038530067,0.022999067,0.003925274,0.10665661,0.03111354 +2.7.8.5,The enzyme catalyses the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins.,384,1.0,-0.04138405,0.03303911,-0.11177685,0.028622426,0.02791237,0.046065852,-0.055231865,0.020885373,0.061589543,-0.025614453,0.016509982,-0.043705918,-0.102064185,-0.022515306,-0.015093096,0.0012180228,-0.13266452,0.009521988,-0.022068532,-0.050071094,0.069860965,0.013857939,0.0058514355,0.072554,-0.012193234,0.010713528,0.06377244,-0.07449875,-0.019721374,-0.009980534,0.014094029,-0.04759071,0.08058667,-0.04908017,0.009470587,0.115713194,-0.011462588,-0.0009629737,0.031100117,-7.198181e-05,0.05250382,-0.03465548,-0.041946694,0.009197526,-0.039396282,-0.0047460264,-0.05703114,0.040910188,-0.03228267,0.025048666,-0.07340442,-0.043480333,-0.048272215,-0.041850958,-0.0017129988,0.042497534,-0.055922013,-0.01742212,-0.009199775,0.00018801306,0.005736069,-0.017026521,0.002683348,0.06291791,-0.088947974,-0.08050887,0.06259379,-0.058415335,0.08136317,-0.017593414,-0.0515961,-0.040546086,0.022096612,-0.04447934,0.06995571,0.051100474,-0.020940673,0.018875696,-0.009731348,-0.057950027,0.052489784,-0.04326275,-0.038354356,0.092426926,0.004583258,0.0092837615,-0.009301478,0.021017605,0.032647256,-0.00067113683,0.011015173,-0.098527916,0.056260884,0.0027000492,-0.05615027,0.017705081,0.014669881,-0.05371551,0.0044909804,-0.028713377,0.029923502,0.054573648,-0.04744213,-0.0706574,0.023611918,-0.0216955,-0.04054961,0.03972555,0.008370915,-0.0010746475,0.065232635,-0.055674743,0.10068649,0.00075059454,0.00731809,0.079010434,-0.048975218,-0.07255797,-0.029136222,0.05440591,0.014526662,-0.016688427,-0.009901083,0.040229592,-0.12226273,0.036149517,-0.086077146,2.3062374e-33,0.08451289,0.034634557,0.008937233,-0.03356926,-0.004554122,-0.04192657,-0.11011587,-0.0105600925,-0.022855468,0.0015578892,0.0018652369,-0.09624989,0.012703872,0.033696257,-0.018234927,-0.023705035,-0.038232945,0.07911843,0.070821576,0.036788095,-0.044632882,-5.9700265e-05,-0.02581814,-0.02141439,0.033616476,0.13411486,-0.07862312,-0.022320794,0.055305306,0.004534073,0.061665956,-0.094651416,-0.04993509,0.025529906,0.020927217,0.019129565,-0.01709597,-0.07218317,0.0045153364,0.027369317,-0.048359927,-0.015806219,-0.03847604,-0.040017385,0.05556364,-0.0085038915,-0.066580184,0.039203737,0.08944749,0.032323748,0.010561353,-0.01975666,0.18240751,0.04684603,-0.047836818,0.0034022948,-0.04938714,-0.0131067,-0.0060459957,0.023995567,-0.010253815,0.08135462,-0.053726006,-0.0026517005,-0.039286066,0.0014193926,-0.020128615,-0.017705636,-0.10480963,0.083034836,0.020640105,0.0077198436,-0.014817132,-0.0035080137,0.034506552,0.006634042,0.027932623,0.056032512,-0.07919218,0.039272353,0.016005533,0.055755273,-0.02788815,-0.0435578,-0.040571205,0.05657272,-0.0054070186,-0.05413986,-0.050778147,0.069184616,-0.09879969,0.0019076492,-0.036187522,0.06548888,0.00088893424,-4.037941e-33,0.063584894,-0.07251934,0.015441031,-0.1220142,-0.029878814,0.037423793,0.011229007,-0.04586642,0.07817203,-0.061765935,-0.06314481,-0.010649965,0.039004073,-0.0051537557,0.038191084,0.056675065,0.0037783985,0.04144067,0.06547954,-0.0117024155,-0.008959904,0.052780166,-0.0443284,0.10315623,0.07338276,-0.017530415,-0.0022714096,0.056466896,0.012906321,0.030317936,0.017127512,-0.044119403,-0.08939783,0.002187493,-0.037788834,0.06773672,-0.06672345,0.10176317,0.07894336,0.032984808,-0.054531664,0.029376667,0.036640476,-0.03728109,0.053413168,0.036881488,-0.03353991,0.055566672,-0.04866756,-0.077346385,-0.023606485,0.04549663,-0.051560257,0.053910073,0.022294946,0.12050282,-0.021538615,0.06244932,0.020385304,-0.114235684,-0.07797624,-0.07536965,0.038830973,0.054320723,0.008952764,0.07421308,-0.02672279,-0.042755432,0.01753458,-0.029339893,0.05582052,0.07789182,-0.043293256,0.04954486,-0.0015667567,0.00542647,-0.08146956,-0.12316541,0.0120034125,-0.03323853,0.05375259,0.01001585,0.07106732,-0.08799192,-0.04586233,-0.029872537,0.025548344,0.07264585,-0.018206794,0.00944595,0.0054027946,-0.02480312,-0.036601905,0.02745584,0.011038711,-2.7981685e-08,0.08530593,-0.055456534,0.016210796,-0.032306105,-0.018816382,0.012724591,0.052070513,-0.017044015,-0.004849811,-0.08514759,-0.033508725,0.03280514,0.028079463,0.027845068,0.064795926,0.032945175,-0.061518855,0.02688331,-0.026047675,0.010977105,-0.018178672,0.0005470109,-0.022486858,0.04863275,-0.022926565,-0.040995937,0.06976609,-0.048739452,-0.0013894466,0.05790342,0.03620861,0.022463294,0.007431195,-0.006494948,0.061919205,0.011099414,-0.045397058,-0.050293297,0.0004251192,0.06331916,-0.017508607,-0.040079255,-0.028096765,-0.0070492346,-0.04935212,-0.0040302286,0.029165551,0.034271654,0.024293192,0.027220124,0.016486935,0.030475087,-0.0134491,-0.020857738,-0.08192125,-0.07113046,-0.0007626679,-0.06383475,0.0070665646,-0.03113443,0.013656291,0.088739365,0.2651696,-0.018653842 +2.7.8.7,"Requires Mg2+. All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post-translational modification of their constituent acyl-carrier-protein (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4'-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain [3]. The enzyme from human can activate both the ACP domain of the human cytosolic multifunctional fatty-acid synthase system (EC 2.3.1.85) and that associated with human mitochondria as well as peptidyl-carrier and acyl-carrier-proteins from prokaryotes [6]. Removal of the 4-phosphopantetheinyl moiety from holo-ACP is carried out by EC 3.1.4.14, [acyl-carrier-protein] phosphodiesterase.",384,1.0,-0.06432244,-0.030474296,-0.07853424,0.012135498,0.048675217,-0.00037826074,-0.016099699,0.007528792,0.029235581,0.0022265299,0.0721022,0.006678512,0.028462233,0.005336682,0.008589235,0.021804655,-0.022356141,0.024961863,0.010261397,-0.014157733,0.06108232,-0.0237982,-0.03217168,0.0018094962,-0.03887928,-0.081422545,0.08221224,-0.024695165,-0.07108585,-0.013927713,-0.05386158,-0.0369109,0.004052631,-0.052798558,0.041784544,0.08158624,0.0043609184,-0.064036645,0.016481379,-0.084927104,0.12342121,-0.052090846,0.017197115,0.0012652104,0.025172586,-0.020505125,-0.03821768,0.02573932,0.04564923,-0.00018961685,-0.031225583,0.019470736,-0.033202983,-0.005837822,-0.05949659,0.04657047,-0.07712579,-0.034429155,0.0043706126,-0.0139097655,-0.10092072,-0.0059039653,0.012767943,0.024099162,0.0341992,-0.044609725,0.06514632,-0.055895697,-0.018334271,0.02631114,-0.0067552514,-0.045949444,-0.017200992,0.022292778,0.033493064,0.079146534,-0.040603522,-0.007854763,0.005643979,-0.0029014882,0.053507965,0.036192082,0.07225588,0.030772908,-0.00082232914,0.011923817,0.02039636,0.042442787,-0.02953417,0.036793005,0.05128812,-0.059131887,0.048140213,0.02868317,-0.049397606,0.048848968,0.0039909924,0.037721816,-0.03841638,-0.04000946,-0.03693058,0.08154951,0.012992409,-0.07999118,0.00023403963,0.032517564,-0.015147222,0.068045154,0.031979375,0.05115811,0.02277226,-0.014867143,-0.011276976,-0.033733815,0.045142174,0.08397789,-0.051371355,-0.09865854,0.0013315377,-0.01957398,-0.0454619,0.00017928744,0.011403459,0.07205255,0.024937402,-0.03524886,-0.1215035,3.983158e-33,-0.0025450871,0.02642038,0.129027,0.044865537,-0.030041145,-0.032997526,-0.052737456,-0.023590825,0.06099075,-0.03368546,-0.046216946,-0.049024303,0.024362823,0.007900542,-0.022467885,-0.07799619,0.0411887,0.025581025,0.0803244,0.03684939,-0.063238114,0.06423948,0.03931706,-0.039026532,0.017690692,0.12928866,-0.062444616,-0.10400198,0.04395377,0.022580009,-0.029374033,-0.052560188,-0.070416674,0.06960119,-0.03874213,-0.013396094,-0.025863316,-0.07776375,-0.009195939,0.05209679,0.013865084,-0.043506034,-0.052080374,-0.008204231,0.075703144,-0.029547324,-0.023167625,0.02541495,-0.06803492,0.053320374,0.030871082,0.010900852,0.06386587,-0.002909772,-0.120662466,-0.03677549,-0.09802133,-0.072556555,0.04413946,-0.017900588,0.06052391,0.060092807,-0.05254921,0.033860907,-0.053096175,0.006244866,-0.08855707,-0.11820407,-0.062294796,0.15228741,0.05902091,-0.06349716,0.08916282,0.08201368,0.047403652,-0.0022969248,0.0030063405,0.052407682,-0.02000736,0.102194116,0.034263294,-0.010686715,-0.0046506785,0.027735183,0.040919125,-0.019938206,0.027508838,0.0036939206,-0.0052263252,0.0058782236,0.074762024,0.0015797865,-0.0066724946,0.08957852,-0.04629479,-5.9991248e-33,0.14182012,-0.090729095,0.053601805,-0.17145197,-0.10732817,0.0354677,0.04108377,0.004632676,0.06528971,-0.05572544,0.07801028,-0.07461537,-0.0033524819,-0.1295912,0.0130623365,-0.014907241,-0.045537233,0.0732075,0.0045597237,0.04047976,0.00228395,0.025413651,0.017725166,0.11454499,0.04640177,-0.030561846,0.015648032,0.06419382,0.024801036,0.06538536,-0.024516111,0.012015782,-0.036684714,-0.0009608682,-0.07642475,0.010071983,-0.08594535,0.038637515,0.028009282,0.06646724,-0.0024887705,0.0084155435,0.033135384,-0.04277628,0.05516902,0.08356402,-0.020844975,-0.01072765,0.013652629,-0.11245779,0.041239507,-0.007177698,-0.040945895,-0.027831694,0.016483855,0.084379256,-0.01382412,0.025966998,0.046065956,-0.10306258,-0.051790483,0.004267505,0.035684228,0.022632856,-0.004522509,0.13563196,0.053087298,-0.039325017,-0.06992905,0.039455026,-0.022338584,0.04235289,-0.021553045,0.019829366,0.077022806,0.013388387,-0.0764214,-0.0610959,-0.03196095,-0.084175296,-0.06874786,-0.026026022,-0.026124403,-0.016579604,-0.04655353,-0.06363978,0.017019136,0.040778097,0.0027948362,0.039387118,0.008903392,-0.00076201593,-0.045227874,0.06699498,0.0020857258,-4.8612304e-08,0.00496707,0.015833171,0.02840578,-0.07930575,-0.025861971,0.03318897,-0.009399889,-0.08082544,0.058681265,-0.07203688,-0.054351833,0.028030833,0.0138445245,0.0031566403,0.010428307,-0.0255592,-0.009909987,0.041614994,0.020736761,-0.05775637,-0.061805483,0.0055706687,-0.0074443943,0.06491159,0.015051481,0.004639361,0.041266575,-0.04119207,0.028609492,-0.020975836,0.024406621,0.0014173184,0.003759054,-0.006735855,0.04582798,-0.01766626,0.0011572634,-0.066494584,-0.055725615,0.08303707,-0.027480062,0.018570062,-0.001425637,-0.01186946,0.082264684,-0.022752708,0.038446933,-0.013350104,-0.027072454,-0.030965554,0.042042598,0.044606496,-0.08657838,-0.09865694,-0.06684491,-0.025965199,-0.012392657,-0.13586973,-0.022477545,-0.057372324,0.038730603,0.0012592361,0.10923447,-0.007323883 +2.7.8.12,"Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme adds 30--50 glycerol units to the linker molecule, but only after it has been primed with the first glycerol unit by EC 2.7.8.44, teichoic acid poly(glycerol phosphate) primase. cf. EC 2.7.8.45, teichoic acid glycerol-phosphate transferase.",384,0.99999994,-0.029167656,-0.08355628,-0.06977657,-0.040625904,-0.003714537,0.07248427,-0.05932413,0.08329589,0.047927562,0.0006810224,0.054748356,-0.019894946,-0.014600635,0.039522666,-0.057228085,-0.0721336,-0.018646834,0.00093660667,-0.05261656,-0.077277966,0.048199084,0.047008537,-0.043266203,-0.018065449,-0.0015280059,-0.0003497636,0.02501114,-0.033260986,0.01766097,-0.024535665,-0.00032454735,-0.08294988,0.05155171,-0.09819874,0.09799682,0.0879257,-0.05594896,-0.006533718,0.07643015,0.037537947,0.085582934,-0.05326581,0.020135345,-0.021044828,0.0004672396,0.040160228,0.025357286,0.02208742,-0.019454027,-0.03627469,-0.05535605,0.043854237,-0.062125646,-0.031893425,0.023072695,0.031084267,0.027831335,0.025922287,-0.0051195496,-0.020326164,-0.03282556,-0.02624565,0.05296783,0.0062492043,-0.027741214,-0.06986975,0.10087831,-0.003809302,-0.026950296,0.014542921,-0.006277064,0.04376217,0.084725544,0.02040757,-0.016457776,0.044088323,-0.07588583,-0.028073084,0.0022715458,-0.0331114,0.028870946,-0.096945405,-0.05276094,0.06996725,-0.060646597,-0.047066048,-0.0047670333,-0.020176033,0.011110443,0.047375295,0.084024854,-0.01659086,0.0404252,-0.07381158,-0.044553168,0.009732599,-0.037354726,-0.0380896,0.04089246,-0.1310712,-0.06685983,0.0197962,-0.0044912975,-0.06611072,-0.04420081,0.0259428,-0.029124739,0.098001204,0.05846055,0.08189394,-0.0034662066,0.024962077,0.04640921,-0.018211659,-0.022554176,0.04843832,0.02663244,-0.0788317,-0.021711962,-0.018279076,0.02680954,-0.08882589,0.07932601,0.061682668,-0.06440828,0.043724284,-0.01476055,3.540478e-33,0.11831436,0.073969394,-0.03728496,-0.072261274,-0.03047804,-0.032205876,-0.076741345,-0.04389047,-0.08081391,-0.037365258,-0.068848856,-0.049945164,0.0063084643,0.039147377,-0.0117591275,0.061873812,-0.0020309314,0.018211143,0.054058917,0.00016207968,-0.00067557045,0.087861694,0.027119994,0.0047534285,0.048547704,0.06224509,0.0042251907,-0.0457244,-0.03357983,-0.024166651,0.04341077,-0.09257471,-0.08833259,0.040098332,0.16996896,0.0008518969,-0.08348665,-0.029187413,0.055127926,-0.001078897,-0.012506365,0.0454676,0.086846896,-0.0154447425,0.07380268,0.03243553,-0.016863087,0.016708713,0.0180923,0.044220973,0.031755142,0.04575381,0.05221388,0.026956975,-0.058924433,-0.020422436,-0.02651861,0.02092633,-0.0043569803,0.047479916,0.009653001,0.084297165,-0.054881338,-0.0059163095,0.011169496,-0.007938367,-0.07925581,-0.005997797,0.05268345,0.007264826,0.015421459,-0.05087108,0.07085184,0.030098103,-0.026348615,-0.0076448927,-0.043309473,-0.0025449663,-0.013206639,-0.058900077,-0.03583599,0.02058084,-0.028889658,-0.028311001,-0.035871454,0.029686106,-0.006869957,-0.046797603,-0.042494975,0.020833358,0.09517309,-0.09828453,0.0010378022,0.08054294,-0.07152371,-5.090121e-33,0.10130016,-0.06343819,0.1329676,-0.046169985,-0.032101236,0.0050378423,0.0077797524,0.029505229,0.01090636,0.0012285654,0.063196026,0.04428877,0.09290352,0.00056935044,-0.01461678,0.026473397,0.046240564,0.07631552,-0.07864166,-0.12945674,0.056242563,-0.040893458,0.014326387,0.05307163,0.036963664,0.048233032,-0.026799008,0.016108727,-0.023986742,0.05880795,0.00801548,0.059282865,-0.095796265,-0.029546333,-0.020122267,0.0014011312,-0.019060556,0.015161386,0.05053867,-0.030039342,0.07968958,0.03011685,0.07751634,-0.013127655,0.041801423,0.07354073,0.0014560681,-0.06586478,-0.049377877,-0.03805451,-0.0158179,0.03591427,-0.016500233,-0.01420386,0.067217305,0.030332962,0.03330875,0.07848911,-0.03975253,-0.087057896,-0.008934718,-0.10236277,0.050975937,-0.022676459,0.0009160135,0.097247444,0.04776026,0.004490134,0.04785051,0.017289212,-0.003174856,0.055633854,0.0072488943,0.036612332,-0.02890606,-0.0032473553,-0.094935,-0.076368004,0.01864937,-0.0037137277,0.017002905,0.019059861,-0.010139289,-0.081738316,0.0635585,-0.07526541,0.0746295,0.10720908,-0.021653162,0.038093846,-0.06393668,-4.1194246e-05,-0.023097243,0.0043287594,0.053764913,-4.409749e-08,0.017409205,-0.052492302,0.0051039173,-0.07916822,-0.015552237,-0.010540224,0.005363871,0.04522603,0.039432988,-0.03571585,-0.04212071,0.02330704,-0.037634343,0.0117808785,0.024954848,0.05159108,-0.09292385,-0.08530171,-0.020279331,-0.11371476,-0.041145835,-0.0012136752,-0.12323519,0.08467063,-0.033013873,-0.036488913,-0.011404237,-0.017019568,-0.02520916,-0.0057599656,0.021980785,-0.016791144,-0.063052125,-0.0154237915,0.018845584,0.036836788,-0.004869253,-0.01607137,-0.008797677,0.053664062,-0.01155989,-0.028649362,-0.10329962,0.06847621,0.088822894,0.033815037,-0.035639644,0.06729351,-0.10094917,-0.018907513,0.0376583,-0.021626038,-0.030224277,-0.07071445,-0.11358155,-0.019788604,-0.026949367,-0.05492595,-0.03055804,0.020997025,-0.009026832,0.016730791,0.12451926,-0.050623573 +2.7.8.13,"In Gram-negative and some Gram-positive organisms the L-lysine is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm), which is combined with adjacent residues through its L-centre. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here).",384,1.0,-0.031512264,-0.08571623,-0.031363416,-0.0031409925,0.088714726,-0.043632157,-0.017979426,0.077826545,0.110995136,0.035574187,0.076885976,0.00097568386,-0.0048411866,0.033017144,-0.061098497,0.061344765,-0.024715703,0.007359404,-0.062353153,0.028919859,0.096467495,0.047878306,-0.07369535,-0.0052759503,0.072938845,-0.0326961,0.020357281,0.052895535,0.09345882,-0.08601333,-0.008385624,0.0019030652,0.06339184,-0.07069519,0.035281204,0.046341363,-0.04158994,-0.042015586,0.09733052,0.055510823,-0.022012454,-0.047474336,-0.014226738,0.019159464,-0.030585887,-0.007455781,-0.1116423,0.07801006,0.022526665,-0.02295218,0.053354613,-0.023816368,-0.0848428,0.09856559,-0.08514365,-0.034028623,-0.16216685,0.050068583,0.00028610302,-0.018275173,0.041391477,0.12584557,0.016654309,-0.0015359424,0.018995753,-0.0058735856,0.005251231,-0.064551756,0.11604237,0.025419466,-0.059142567,-0.052142534,0.08718079,0.031911183,0.062311828,0.054602854,0.007143116,0.026604524,-0.014428041,-0.04215643,0.0543916,0.04812435,-0.01267994,0.08187277,0.0322716,-0.01715422,-0.054182634,0.050595056,0.0018933208,-0.04304127,0.00031002733,-0.06080463,-0.03868424,-0.06285909,-0.04246921,-0.031951953,0.023444891,0.0519826,-0.0013353629,0.0005788376,0.027534336,0.034307577,-0.1300318,-0.04902719,-0.09861251,-0.03964041,-0.00436843,0.0109677585,0.04742993,-0.03407536,0.007285652,0.034174785,0.052796554,-0.00350677,-0.02992547,0.033929747,0.024732063,-0.030013207,0.028822523,-0.022001998,-0.037988506,-0.020067954,0.009895327,0.027379056,-0.0817931,0.06708216,-0.027563041,2.1642961e-33,-0.028964793,0.054820962,0.032714173,-0.03482066,-0.020720825,-0.008008991,-0.08461763,-0.03654678,-0.007797103,0.017542833,-0.062900595,0.0016979881,0.0046262844,-0.024502063,-0.007631299,0.010487952,0.005284978,-0.022179257,0.042867936,0.035377435,-0.008589243,0.10231877,-0.020099169,-0.036302507,0.057548672,0.10257607,-0.011315356,-0.005244073,0.0038358737,0.022899447,-0.02093315,-0.074433215,-0.028729094,0.015123297,-0.035740834,-0.042850163,-0.07583702,-0.052282635,0.016346565,-0.023091517,-0.010077764,0.07554405,-0.03385594,-0.021560578,0.08440315,-0.059754744,-0.020451738,0.087128006,0.07006034,-0.012194898,0.06722353,-0.028001402,0.0074920873,-0.09436758,-0.09909625,-0.031654887,-0.046313945,0.009250121,0.037471153,0.09856454,0.07172082,0.08518186,-0.04807256,-0.004117977,0.043520898,0.01782836,-0.09202496,-0.012138613,0.05033238,0.014045034,-0.0878064,-0.070247054,0.067746,0.06586003,0.020371739,-0.011590712,-0.039367843,0.034729276,0.08933389,-0.02384083,0.04588582,-0.038249988,0.034254164,-0.033664577,-0.043515116,-0.014854908,0.00907755,-0.10583775,0.006940119,0.054111145,0.063645,-0.061686806,-0.046076704,0.002605188,-0.0097274305,-4.43162e-33,0.049695432,-0.06639312,-0.03155523,0.005435312,-0.040583327,0.026810773,0.0064279265,-0.018124077,0.082185544,0.0055519007,0.100001976,0.007730327,-0.0053563537,0.018995063,0.04210855,0.034700006,-0.048355244,-0.0016542502,0.007415133,0.008243052,0.006756387,0.03375925,0.026253853,-0.0052021192,0.05204301,0.029195689,0.031647176,-0.0010660262,-0.0064365203,0.031804476,0.0076447916,0.027160145,-0.05464032,-0.10541694,-0.03744748,-0.056029495,-0.07397922,-0.05014938,-0.034008343,-0.024205886,-0.025516732,0.007376397,0.04248919,0.031366333,-0.030803377,0.036016095,-0.07800016,-0.022567669,0.07292817,-0.046520934,-0.015054125,-0.056122355,-0.029003076,0.005139427,-0.0063986373,0.060371336,-0.03336402,0.0481978,0.00900079,0.020210348,-0.052104194,-0.057158124,-0.0733794,-0.024299832,0.07135705,0.047651052,-0.027294315,0.074418604,0.039225023,-0.10687926,0.09375871,0.016748546,-0.011430173,-0.073546305,-0.046039913,-0.019660408,-0.03682322,-0.09196573,0.044737753,-0.061191108,-0.07605645,-0.026523568,-0.03971133,-0.04421594,-0.03261941,-0.060426936,-0.025415914,0.14729051,-0.018045757,0.026699606,0.054859336,0.018632174,-0.05573245,-0.03459412,0.14657544,-4.96834e-08,0.027639464,-0.06380722,-0.0020499118,0.0149686085,-0.012347432,-0.054099623,-0.030932447,0.067862175,-0.011105012,0.05129571,0.03409025,0.04539158,-0.022973932,-0.10446455,0.008385424,0.0699751,-0.022821678,0.071387194,-0.03712757,0.027262919,-0.03716426,-0.0024629598,-0.0333786,-0.044498477,0.08421897,-0.114171475,0.022569474,0.037757084,-0.0350943,0.029772626,0.052614585,0.00031959548,-0.0077021206,-0.05469076,-0.041959565,0.05839898,-0.03881414,-0.015104251,-0.029897548,-0.02926962,-0.009212386,0.021799343,-0.09542678,0.045519225,0.025758341,0.01939601,0.00911689,0.060418338,-0.039658826,-0.023577144,-0.005045969,-0.058750294,0.019065661,-0.0344759,-0.024903305,-0.02147815,-0.063980155,0.038176835,0.02927434,-0.034572024,0.0024098493,0.07535162,0.17499015,-0.041908227 +2.7.8.14,Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds around 40 ribitol units to the linker molecule.,384,1.0,0.02826534,-0.0585987,-0.11100723,-0.050360456,-0.034221154,0.0668397,-0.11183687,0.057196267,0.09535959,0.03563875,-0.00055056025,-0.043435633,0.017776178,0.035927735,-0.052493222,-0.036715873,-0.08047848,-0.0034437042,-0.0088940235,-0.03212646,0.068701215,0.0856737,-0.036088042,-0.032821905,0.012996283,0.03831788,0.033970907,-0.022084646,-0.018023303,-0.045952532,-0.041928183,-0.05591124,0.059812333,-0.06477634,0.018007394,0.0726449,-0.05010438,-0.0051919864,0.086180456,0.025486037,0.00082209933,-0.0066370834,0.033861782,-0.0042906236,-0.0014561246,0.015891356,0.0434271,0.08758893,0.05380822,-0.0220059,-0.04916034,0.060567845,-0.0808877,-0.039980058,0.0096353665,0.04200622,0.031175837,-0.018215062,-0.010859564,-0.039528545,0.029756881,-0.06987964,0.046694998,-0.0015356513,0.016015958,-0.0572296,0.035283335,0.0063077332,0.01248538,0.024833944,-0.035866473,0.04375177,0.0494465,0.010834029,-0.023073783,0.047692254,-0.003452222,-0.03582799,-0.0030756956,0.0039121597,-0.019894945,-0.0418208,-0.07284863,0.099108376,0.023812458,0.035093587,-0.0111157745,-0.022703169,0.033833385,0.08096539,0.05811799,0.0052442052,0.053777065,-0.096531175,-0.016993776,-0.007869666,-0.057522345,-0.017719565,0.005651994,-0.093562976,-0.057019517,0.016791828,0.018226175,-0.02809478,0.015569257,-0.012769191,-0.0412023,0.1012179,-0.022483442,0.05387767,0.061763268,0.014953877,-0.05609564,-0.04537537,-0.0070515224,0.069214016,0.082554854,-0.15317245,-0.041706916,-0.038104687,-0.011896273,-0.062213402,0.04216346,0.050794244,-0.068427175,-0.05130677,-0.03423715,1.773224e-33,0.052623603,0.038354475,0.017677765,-0.057370897,0.02560649,-0.0029097537,-0.07138206,-0.061045572,0.0171013,-0.010758238,-0.13640395,-0.04972339,0.09472915,-0.038709372,0.02819129,0.005993145,-0.025348807,0.030750735,-0.0029137987,-0.021442212,0.00012595468,0.10380415,0.026212092,0.045263827,-0.015169565,0.04052954,0.020140551,-0.06011358,-0.021484805,-0.017077256,0.008902968,0.009627177,-0.056570932,0.014509232,0.12593774,0.007307215,-0.10750477,0.0033760075,0.101276994,0.02016778,0.05266797,0.023471968,0.059486795,0.01810737,0.045538574,-0.03204113,0.021294687,0.022914039,-0.046107646,0.06787046,0.07572391,0.013594982,0.02551166,0.0074607925,-0.04180132,-0.02155917,-0.049572993,0.021502288,0.014989972,0.12371347,0.00015609938,-0.0036617827,-0.031870827,0.07353564,-0.03842896,-0.024379278,0.004565887,-0.031045582,0.020806545,0.017560737,0.020393804,-0.05990426,0.073085144,0.00094022974,-0.0709788,0.059166174,-0.036286004,-0.011751006,0.021663958,-0.043205254,-0.030099373,0.004322437,-0.021340575,-0.07323838,-0.03884762,0.036792304,0.047403276,-0.0708458,-0.035591222,0.046917066,0.08196086,-0.09372672,-0.049361967,0.06075344,-0.024705393,-4.2103214e-33,0.11458784,-0.16921559,0.10134992,-0.10599174,-0.053230975,0.031017605,-0.018463058,-0.02762788,-0.023623163,0.0019975407,0.070037745,0.05302924,0.045257866,-0.0008880402,-0.031968594,-0.008966464,0.07939953,0.10142871,-0.03672846,-0.031079574,0.011834568,0.013140583,0.05329224,-0.004853759,0.0041097235,0.055542376,0.025285099,-0.010440764,0.021568865,0.018611703,-0.00012559564,-0.0044244565,-0.069036916,0.019588288,-0.054323968,0.04244035,0.007820855,0.03477706,0.125136,-0.022858528,0.055786733,0.053103525,0.016320165,-0.0066393805,0.03311234,0.039997496,-0.06444747,-0.03148891,-0.10221483,-0.10084447,0.06503522,0.016114317,0.054523464,0.008009942,-0.016472086,0.04406526,0.005693861,0.018875742,0.013270162,-0.021937136,-0.04925852,-0.103130415,0.031755712,-0.045987595,0.00030275495,0.006148636,0.032993354,0.005789084,0.0074383975,-0.039830428,-0.0055092955,0.044087727,-0.027921136,0.03358258,-0.015620651,-0.08397887,-0.10067811,-0.07614726,0.01693665,0.0106797265,-0.07897138,0.030062368,0.00046131015,-0.036137592,0.05272373,-0.07026042,0.08629344,0.09578831,0.006556874,0.050971802,-0.0414921,0.020786852,-0.014908533,0.043624222,0.076752536,-3.1250618e-08,0.06782276,0.0055346475,0.045860976,-0.048975702,-0.032091726,0.0047596316,-0.059261285,0.021927092,0.06719926,-0.01853306,-0.008901314,0.014828667,-0.042802636,0.00020555967,-0.029680993,0.05757165,-0.14131305,-0.10295421,0.006809488,-0.10318355,-0.048146304,0.015198175,-0.07436561,0.049956363,-0.01792907,0.014005303,-0.03812791,-0.06074438,-0.004225505,-0.0139407655,0.05025157,-0.028629545,-0.009982648,-0.04940802,-0.060326554,0.00094729185,0.06643438,-0.079279594,0.013513008,0.050839704,0.009101164,-0.049374055,-0.06584536,0.046387177,-0.014345576,0.056239955,-0.055989902,0.073588185,-0.06921939,-0.015005909,0.06283139,0.065058045,-0.054414503,-0.04488964,-0.11313171,-0.02038915,-0.025279153,-0.09991489,0.0036707988,0.07227613,0.029495535,0.015691657,0.0777813,-0.029042294 +2.7.8.17,"Some other glycoproteins with high-mannose can act as acceptors, but much more slowly than lysosomal enzymes.",384,1.0,0.03449821,-0.13697961,-0.037800364,-0.06254961,0.054522764,-0.028807122,-0.026602738,0.010253915,-0.025519846,0.06839871,0.082410306,0.040693454,-0.060000762,0.05558232,0.03745732,0.03716253,-0.027136497,-0.030200249,-0.07671457,0.023075843,0.038051117,-0.0022464972,0.014556399,-0.01975352,0.027305534,-0.1450526,-0.06544889,-0.07283686,-0.025591018,-0.13565725,-0.10298727,-0.028301898,0.02692597,0.008936062,0.002993041,0.064391695,0.005711407,-0.017156433,0.031885795,-0.088082254,0.009062637,-0.102915324,-0.0310264,-0.02805476,-0.12534991,-0.022428187,0.0013848329,0.037367694,-0.0023205932,0.04549421,-0.07981485,-0.019911997,-0.010880669,0.0019129039,-0.088407256,0.04466793,-0.07608603,0.017963735,0.050233893,-0.010368995,-0.107113265,-0.015626736,0.049389843,-0.007966115,0.043808624,-0.090733364,0.06801793,-0.04934231,-0.021664934,0.062066592,0.101029664,-0.054996237,-0.045966253,0.009281915,0.08389892,0.022660082,-0.013022245,0.0067503704,0.06293296,0.011516087,-0.0027397377,0.010017081,0.07653716,0.03161552,-0.04797263,-0.055549882,-0.0460976,0.06792346,0.006693814,-0.008133492,0.05823744,-0.038727388,0.08285189,-0.0056154756,0.028092626,-0.054488957,0.0692976,-0.018030204,0.007572043,-0.06670478,0.0028726673,0.004988686,0.02499222,-0.04045045,-0.034551587,0.043122835,-0.005006499,-0.032194134,0.014104009,-0.042341135,0.029127052,0.009993458,0.09515869,0.019036375,-0.11099058,0.00398907,0.029207015,-0.088851884,-0.0009971234,-0.036980983,-0.0139302015,0.06785528,0.07633336,0.008534741,0.012079205,0.09186028,-0.046170883,-4.8887933e-34,0.010223679,-0.005516164,0.04519627,-0.025537658,-0.013575059,0.0030123596,-0.025684977,-0.0029091155,-0.071237154,0.006170943,-0.104662605,-0.047690395,0.02271785,0.12018347,-0.06358287,0.056651477,0.014244798,-0.0049186014,-0.02155105,-0.025151717,-0.031526536,0.0030506928,-0.028532133,-0.023144843,0.04995616,0.04164567,-0.013287399,0.06279197,0.028940437,0.01295152,0.06337999,-0.08828493,0.007083508,0.05491355,0.033168815,0.07317991,0.028921261,-0.0067299367,0.059047613,-0.049858935,-0.040392496,0.0269147,-0.073489435,-0.03301574,0.014924419,0.008341081,-0.02865651,-0.03609279,-0.12203808,0.03788489,0.045521315,-0.09511424,-0.045082368,-0.0060593644,-0.012150803,0.06502062,0.004791324,0.055575076,-3.287237e-05,0.09225576,-0.008174936,0.07763142,-0.020319914,0.019354869,-0.028443784,0.01398393,-0.007961679,-0.005172978,-0.03250325,0.003938092,-0.030233106,-0.053037032,0.085728206,-0.015312257,0.04061727,-0.07389163,0.02243848,-0.035119478,0.017557664,0.031475212,0.0558994,-0.03992944,-0.054575548,0.008342042,-0.080447584,-0.023476217,-0.006842657,-0.11761589,-0.018643983,0.03434994,0.0063378923,-0.016566316,-0.047696784,0.05414002,-0.055053934,-2.8917124e-33,0.12938313,-0.11183979,0.15058689,0.03193079,-0.014282755,0.052181985,0.085793,-0.045839783,0.104801595,-0.013013177,0.06382608,-0.0008319315,-0.015958818,-0.040338907,0.044041548,0.008093006,0.027895713,0.05646286,-0.0015348463,0.03281798,-0.056083724,0.05196019,-0.010090369,-0.015933903,0.020216279,-0.019353854,-0.08784499,0.08871679,0.020374795,0.012163362,-0.049397223,0.025754908,-0.011964991,-0.11330094,0.009491505,-0.023905957,-0.0657002,0.02826493,0.019882426,-0.06904077,-0.049757518,-0.0071742632,0.020355841,-0.019692104,0.06332098,0.021338344,-0.017582672,-0.024256544,-0.070307985,0.026962426,-0.0001534979,-0.032808114,0.03816019,0.07979556,0.06970257,0.047401983,-0.0050897077,-0.01955996,-0.027661927,0.01435998,-0.05221981,-0.05963336,0.036679078,0.06987738,0.05170038,0.042605937,-0.076945424,0.015140628,0.056658767,0.0142998705,0.022592127,-0.045245714,0.047952224,0.08735575,0.010552648,0.02226213,-0.17064755,-0.07393005,0.0066628046,-0.070917144,-0.075488746,0.0344991,0.0129813,-0.018079208,0.06728679,-0.028238373,-0.0022872104,0.04142768,0.06630971,0.078491114,-0.02998232,-0.046177834,0.032115396,0.02742996,0.07043399,-2.6817295e-08,0.0998653,-0.008719949,0.049788747,-0.08630525,-0.0042596357,0.02550883,-0.0038296115,0.07079692,-0.020238275,0.054300662,-0.024997184,0.084176354,0.037327394,-0.09007635,0.016127996,0.022400822,-0.012174058,0.0016849691,-0.02185553,0.017588671,-0.1138053,0.04417834,-0.030188002,0.02316386,-0.024263386,0.029294452,-0.0006060672,0.0035917459,-0.07635682,-0.04113656,0.027100094,0.056404714,-0.0058839303,-0.052867875,-0.028298892,-0.0098714,-0.0041113375,-0.046639953,0.031799898,0.032276377,0.023126664,-0.0160855,-0.034146775,-0.041560736,-0.018652866,-0.008256687,-0.006185989,-0.05010737,0.033256616,0.033639308,0.03643517,0.027878262,-0.074161604,-0.02671478,-0.042550627,0.02467636,-0.021916956,-0.009024855,0.017525893,-0.07261749,0.03295134,-0.012658125,0.14678201,-0.049944587 +2.7.8.18,N-Acetylglucosamine end-groups in glycoproteins can also act as acceptors.,384,1.0,-0.03407271,-0.09319749,-0.07680389,0.016458942,0.008089938,0.0094938995,0.04608757,-0.009264749,-0.04802207,-0.00027454918,0.036240965,0.060671844,-0.07586136,0.036462408,-0.07896226,0.03597256,0.008030257,-0.044184845,-0.011198068,-0.015600374,-0.009901324,-0.00988906,-0.013782893,-0.05376141,-0.0060570315,0.006740631,-0.06272459,-0.058777772,0.029390562,-0.11070536,-0.028444145,-0.052739665,0.042361412,0.05413396,0.02502144,0.06392057,-0.028600335,0.038235534,-0.04490052,0.004013253,0.019256359,0.010828442,-0.000515625,0.009840587,-0.03268025,-0.023935327,-0.010498126,-0.0032323753,0.049810182,0.073133565,0.062333796,-0.018878983,-0.028798813,0.101530835,0.01406601,0.052256282,-0.11337949,-0.012567897,0.016687492,0.047300633,0.036776394,-0.0021327764,-0.039931715,-0.04639792,0.02127068,-0.08249746,0.13217372,-0.0192683,-0.07623732,0.06634781,0.055060722,0.013047279,-0.04924245,-0.005161793,0.009651962,0.035684742,-0.089555785,0.005697775,0.052327346,0.0170364,-0.0014748145,0.05018384,0.07479062,0.058140166,-0.009025539,-0.022244964,-0.013972648,0.04203218,0.025363687,0.032394793,-0.054553803,-0.08937158,0.07697058,-0.04307936,-0.0037901085,-0.08924623,0.12706739,-0.019542044,-0.0050730086,-0.024622347,-0.0062494073,-0.019886933,0.040511884,-0.0864631,-0.08004287,0.064012915,-0.039781224,0.019702109,0.094213806,0.028842213,-0.09934611,0.011717833,0.038975038,-0.015950056,-0.0431909,0.002431571,-0.047607217,-0.06656816,0.031419262,-0.05523374,-0.00060983264,0.030340817,0.05105682,0.04869792,0.016586244,0.0954678,-0.016797287,-3.9164634e-34,0.02829849,-0.0048337406,0.047288977,0.0273111,-0.01350235,0.008090369,-0.05930627,-0.004735068,-0.00020047462,-0.038263805,-0.049284138,-0.010845376,0.0735765,0.13947253,-0.006179285,0.07963649,-0.02140338,-0.03665756,0.011966228,-0.086118475,-0.026048265,0.035563003,-0.070355445,-0.027906261,-0.0482936,0.016408766,-0.04911552,0.081275836,0.040912606,0.018113988,0.04575475,-0.066302866,-0.034381334,0.10082775,0.043862093,0.03620606,0.062534206,-0.036838118,0.06738277,-0.024398074,0.01761948,0.051900063,-0.076590054,0.0088111,0.020497961,0.0060600983,-0.030500963,-0.07527649,-0.06332904,0.06531516,-0.018034058,-0.09037584,0.00019824896,-0.028594859,-0.046052407,0.058659423,-0.04411731,0.025106117,-0.043084092,0.03802541,-0.0023846834,0.072866164,-0.019306751,-0.043070763,-0.07193809,0.010550084,-0.0553509,-0.015503325,0.034777086,-0.013427257,-0.021188552,-0.028307684,0.0443343,0.10322406,0.0022573997,-0.09167719,0.029034428,0.04881647,0.032684885,0.046336584,0.015996726,-0.008397941,-0.057594836,0.0008290895,-0.07691657,-0.021445831,0.053218782,-0.19497123,-0.034229398,0.019321749,-0.01718182,-0.04030919,-0.008087349,0.09225507,-0.025479503,-2.966149e-33,0.13476118,-0.108156465,0.11118302,0.0045498116,-0.03819967,0.061500784,0.0650048,-0.04876873,0.076633886,0.017654017,0.07512065,0.019358367,0.019478476,0.035476867,0.05964338,-0.10405985,-0.028159427,0.04812301,0.04654906,0.02326242,-0.024036214,-0.04593241,-0.06672275,-0.023004474,0.009825449,0.00926509,-0.071365125,0.0035452507,0.024506604,0.071398884,-0.008729932,0.018289194,-0.05895714,-0.06616638,-0.008444694,-0.016195875,-0.04265413,0.02467043,-0.059835166,-0.10407685,0.021973928,0.05052895,0.013015408,0.07632376,0.080003925,0.0038154968,0.03595958,-0.033616025,-0.06402209,-0.053452075,-0.009605134,0.0068597323,-0.008270806,0.0511951,0.031991385,0.06370604,0.039576277,-0.012555526,0.021784535,-0.049381,-0.05261845,-0.01656343,0.019521998,-0.021110415,0.022396559,-0.01913687,0.0014169039,0.018211296,0.08118819,-0.024287801,-0.02792272,-0.065253355,0.06578064,0.057213623,0.029002821,-0.014882377,-0.11126909,-0.058800496,-0.050255228,-0.0914708,-0.045652553,0.011778983,-0.022215322,-0.011422557,0.018359244,-0.02141138,0.038250096,0.09096214,-0.038431466,0.07393879,-0.002745186,-0.041725013,-0.013615319,0.07530899,0.007233948,-2.6068637e-08,0.053083282,0.005608141,0.031095302,-0.1272161,-0.050269365,0.053383484,-0.0005635213,0.029817564,0.022498602,-0.015819855,0.027441723,0.11921272,0.020918187,-0.019108042,-0.049572166,0.08924797,-0.042560577,-0.056759313,0.024085492,0.06226028,-0.16405821,-0.033304006,-0.030587487,0.0027815346,-0.047620345,-0.003160312,0.03560807,0.10778705,-0.06401787,-0.031248938,-0.00013575568,0.040832482,-0.03536356,-0.05172929,0.03629438,0.011517161,0.04561977,-0.006964371,0.046671264,0.02089163,0.038579665,0.025140472,-0.043056715,0.015858533,0.019122824,-0.014280282,0.048824843,-0.042904086,-0.08191452,0.047641356,0.0052724923,-0.05693838,-0.08372713,-0.07558962,-0.061228264,-0.020021383,-0.049964376,-0.0127311805,0.0067060883,-0.01286438,-0.045378685,-0.00986782,0.061535694,0.039396532 +2.7.8.19,Penultimate mannose residues on oligo-mannose type glycoproteins can act as acceptors.,384,1.0,0.025874209,-0.052149337,0.011015239,-0.042481307,0.04102434,0.00674701,0.07485159,0.005499549,-0.011055803,0.041277677,0.07021118,0.06714394,-0.10313927,0.028094744,-0.02527188,-0.032064356,-0.009528544,0.013924434,-0.03591134,0.051127814,0.0632935,0.0036406328,0.01472843,-0.0145222135,0.009742662,-0.06642417,-0.062266417,-0.060583815,0.034825187,-0.14586788,-0.090399966,-0.08297711,-0.018964764,-0.0027580392,0.06609843,0.010347124,0.038986247,-0.032965068,0.01576688,-0.063100636,0.052694537,-0.045982827,-0.035883445,-0.03211978,-0.09906009,-0.026781699,0.0004956916,0.0320872,0.019592471,0.09364753,-0.019814061,-0.026025552,0.0024810208,0.005113266,-0.0038128723,0.03653537,-0.07101579,-0.010574767,0.037597895,0.023858437,-0.043069873,-0.016467698,0.03602209,-0.03132076,0.005632119,-0.11433328,0.105353974,-0.061190426,-0.04205747,0.06377041,0.052681427,-0.017238691,-0.03733059,-0.04995341,0.04346928,0.07292761,-0.038388565,-0.034057952,0.063648544,0.05659808,-0.004289377,0.013497833,0.10749881,0.022002164,-0.038142893,-0.022157848,-0.041493297,0.021630907,0.046990484,0.0027811336,0.0070495885,-0.029003507,0.10342002,-0.036297955,0.044322602,-0.07079997,0.066151194,0.018015312,0.047584124,-0.018627387,0.016325848,-0.00016944234,0.035938982,-0.057737708,-0.03914321,0.06849646,-0.046214424,-0.03157473,0.050463665,0.0026758944,-0.012295426,-0.006295121,0.09648943,-0.029533293,-0.12697804,0.002401396,-0.01582006,-0.07913281,0.021994237,-0.08178092,0.0060855164,0.035929326,0.038998865,0.03072659,-0.028218172,0.0797349,-0.03122266,-6.578025e-35,0.04409072,0.03653134,0.08740148,0.007088373,0.036676485,-0.009952444,-0.011313973,-0.01152733,-0.07785048,0.007211289,-0.07911659,-0.04218569,-0.030072972,0.100780964,-0.03407952,0.058516864,0.011163434,-0.009736595,0.012766708,-0.05795136,-0.008101581,0.06409007,-0.015239923,-0.0040121884,0.05500224,0.07382714,-0.062183022,0.079796724,0.0401775,0.021656195,0.1424958,-0.0527303,-0.054783486,0.024855552,0.057302125,-0.0026103784,0.010715415,0.0057477527,0.06494896,-0.0016764345,0.015793277,0.018108614,-0.07619812,-0.033928704,0.02547173,0.0053635156,0.034370903,0.005643929,-0.056429643,0.025447601,0.010037172,-0.06752441,-0.07701099,0.006986747,-0.011660025,0.04096726,-0.049476188,-0.013857234,-0.0011000275,0.10391909,-0.008248571,0.04493774,-0.036633886,-0.046221443,-0.01107197,0.028137498,-0.022187356,0.02618405,0.0034418295,-0.015225133,-0.014690664,-0.042962704,0.06573927,0.031082327,0.016339807,-0.06307118,-0.030185966,-0.012699615,0.0044002444,0.037702516,0.049422182,0.011776824,-0.06175691,0.032635324,-0.11754508,-0.058468085,-0.007657729,-0.12859093,0.0024213295,0.038758013,0.009274705,0.008303663,-0.07794764,0.033344943,-0.12860389,-3.631189e-33,0.11858712,-0.095670365,0.098088406,0.018584289,-0.07765104,0.0052201673,0.10441281,-0.057805855,0.11679384,-0.042029988,0.07342507,-0.014298781,0.029512925,-0.010296203,0.0021708463,-0.016351204,-0.081483275,0.060319096,-0.04785217,0.042854525,-0.041152444,-0.028724352,-0.0020050579,-0.013336013,0.057042968,0.007977724,-0.028531123,0.030597761,-0.0027078243,0.042670064,-0.013952202,0.038574252,-0.04000452,-0.110608295,0.0075078434,-0.054843053,-0.087061696,0.028840441,0.010292661,-0.06560222,-0.056234885,0.018183345,0.0496139,-0.02747985,0.062021952,0.002713374,-0.02805552,0.008462342,-0.06792587,-0.010890475,-0.038422275,-0.02649495,-0.013661832,0.037555415,0.03911895,0.0672653,0.020335779,-0.03140286,0.013868818,0.030405136,-0.02312893,0.0115310475,0.042433873,0.035813853,0.046903726,0.030764418,-0.023516703,-0.04061618,0.08030896,-0.032091994,-0.037821077,-0.047159337,0.06405323,0.028133204,0.046065208,0.03482667,-0.17725885,-0.044172987,-0.036221296,-0.046323106,-0.05721682,-0.006096352,-0.011026466,-0.021502601,0.070620485,-0.0074440716,0.020366851,0.089311115,0.012717446,0.084639825,-0.07242164,-0.053933706,0.0031306122,0.112847015,0.053846598,-2.5365516e-08,0.052414175,0.0008903887,0.034936294,-0.13668273,-0.05448199,0.039489046,-0.019429011,0.007478846,-0.039678358,0.022555295,0.015368753,0.11861719,0.034032866,-0.09054012,-0.03208025,0.038046643,-0.054875787,-0.009226125,-0.027668409,0.016572457,-0.1349184,0.054235876,-0.030290771,0.012025102,-0.028711427,0.017431734,0.016613785,0.05554179,-0.080306835,0.01186313,0.044203416,0.06105193,0.005623573,-0.06448127,-0.022706142,-0.018021237,-0.008709635,-0.021499455,0.012606354,-0.019128209,0.042741623,-0.039830618,-0.013602073,-0.06887387,-0.0011998607,0.03898941,-0.00042239472,0.01408589,-0.045485623,0.09671913,-0.009500906,0.031090518,-0.11424265,0.0018645539,-0.072304904,-0.036676746,-0.032737337,-0.007986657,-0.0058370708,-0.041295007,0.03339526,-0.050914235,0.121729255,-0.05455167 +2.7.8.20,"1,2-beta- and 1,6-beta-linked glucose residues in membrane polysaccharides and in synthetic glucosides can act as acceptors.",384,1.0,-0.016777886,-0.08630585,-0.07519958,0.024144452,-0.011405311,0.028932834,0.08778875,-0.03643263,0.108963534,0.012739257,0.014835469,0.054538887,-0.11113497,-0.00810719,-0.04855529,-0.06308679,-0.009093255,-0.012309206,0.040029593,0.030791167,0.061795514,-0.05107665,-0.030305201,-0.042153925,0.060408182,-0.054374803,0.009768043,-0.08424084,-0.013706011,-0.027226336,-0.090810314,-0.016379558,0.0064972555,0.049536537,-0.037810788,0.10293606,-0.033762816,-0.025705345,-0.012452424,-0.065845154,0.06838876,-0.0062641907,0.050771028,-0.0035858736,-0.01644543,-0.040896352,-0.04602626,0.04937046,0.07616365,-0.014090553,-0.00074704376,-0.031048281,-0.04447216,0.010217561,0.04754673,0.00071187754,-0.06062101,-0.0075452016,0.023898086,0.02989652,-0.02149932,0.0070208926,0.011421109,-0.011043041,-0.07991596,-0.11882013,0.026903957,-0.043114275,-0.0600308,0.054639142,-0.0695144,0.02403691,-0.0020165625,-0.074792445,0.059092037,0.0170412,-0.094734326,-0.00850039,-0.007958646,0.009218033,0.04402089,-0.031882994,0.11120141,0.069220416,-0.02339145,-0.036042456,0.027188385,0.035658948,0.016240481,0.008097563,0.0100669535,-0.014728222,0.051945165,0.042403772,-0.04783201,-0.041278027,0.06526566,-0.017855197,0.091044664,-0.023042167,-0.015732769,-0.009481766,0.09309662,-0.04481289,-0.013876909,0.072413124,-0.023591299,0.06093813,0.02699115,-0.022454867,-0.049513593,0.044069935,0.05501875,0.012637524,-0.103644714,0.01813634,0.02680544,-0.08605501,-0.0059958687,-0.010751687,-0.053267308,-0.016843542,0.037120387,-0.04667339,-0.09022477,0.034930814,-0.017666953,-2.8871324e-33,-0.006961083,-0.002186734,0.029314341,-0.029550703,-0.019330723,-0.017438421,0.0112100905,-0.06438702,0.017696938,0.023735087,-0.10263019,-0.071439266,-0.007289748,0.14836587,0.03642073,0.067176975,0.03225385,-0.042600714,0.13830127,-0.029185878,-0.029773194,0.06825398,0.021622136,-0.09088991,0.08652561,0.014702021,-0.06188249,0.05805995,0.086280994,-0.008158692,0.086931765,-0.01355724,-0.002012923,0.084483184,0.06291942,0.07734324,-0.022753129,0.028818423,0.0010668815,-0.053982776,0.05958814,0.02033195,-0.028095514,-0.040748924,0.04423805,0.033041276,0.028670553,0.021505728,-0.035959117,0.119836025,-0.019909082,-0.0061654383,-0.05006,0.06173991,-0.0049286373,0.058319014,0.009852167,0.014701728,-0.06957725,0.049541645,0.020661352,0.018641163,-0.00096688216,-0.04389196,0.008399165,0.057919394,-0.094397634,-0.016829092,-0.07590731,-0.027629009,-0.061637856,-0.04808549,-0.00084420474,0.05211498,0.0059568295,-0.041982148,-0.059637014,0.018066641,0.012444567,-0.00391202,0.083044276,0.040383335,0.01923334,0.014941067,-0.11958783,0.041815355,0.012764331,-0.04912858,-0.023834448,-0.012390245,0.02877153,0.008532125,-0.08218535,0.06567571,0.017901981,-1.4768255e-33,0.08852195,-0.11650242,0.11791803,-0.0513179,0.004511811,0.0016563205,0.038946666,-0.15912616,0.05379425,-0.029807774,0.047546115,0.08197575,-0.020998314,0.005069517,-0.036323585,-0.01908048,-0.101476125,0.08727134,-0.05909253,-0.041825883,-0.051496807,0.030025324,0.037666384,0.008993571,0.0079833735,-0.021310698,0.05521827,0.010799335,0.030655978,0.020978944,-0.009897092,-0.030102177,-0.030143315,-0.04437611,0.006914516,-0.07358877,-0.073774494,-0.051998224,0.032840963,0.022837592,0.062256705,0.04416071,0.028495414,-0.04124624,0.106430344,-0.011393187,0.006805309,0.013401,-0.063083924,-0.07857396,-0.033456795,-0.036472637,-0.013649031,0.025976222,0.068129726,0.070124194,0.05250766,0.016796036,0.031674284,-0.08120481,-0.04517446,-0.006239795,0.06279603,-0.041179895,0.011012881,-0.01059725,0.04278977,-0.059604198,0.044199355,0.035504635,0.048918348,-0.036328714,-0.07841064,0.029761542,0.011833121,-0.072279036,-0.13826275,-0.024532678,-0.03654793,-0.02457382,0.0097856885,0.063380904,-0.0059671383,-0.017151218,0.094582185,-0.04961045,0.04672997,0.02442611,-0.006917177,0.02863056,0.041026503,0.025762355,0.020839581,0.07521333,0.056187052,-2.7101834e-08,0.048828993,0.006177545,-0.07293778,-0.07947397,-0.10305339,0.01735983,-0.011547436,-0.008024942,-0.04909326,0.018699296,-0.024151148,0.113995686,0.0012460777,0.00095304917,-0.03566191,0.0138945,-0.05301672,-0.027959745,0.010742366,-0.0020865875,-0.060010135,0.02382508,-0.060805283,0.025983725,0.026101103,-0.105650716,0.005589615,-0.0004056611,-0.04365218,0.038805027,0.0418177,0.06926594,-0.0232404,-0.11065955,0.022416398,0.05078166,-0.0068223216,-0.027065733,0.054569993,0.03124622,0.09117974,-0.040532,-0.02294759,-0.041327335,-0.027606627,0.07370505,-0.010063595,0.029047942,-0.08676585,0.07542292,0.012536729,0.020626498,-0.09030423,-0.04223067,-0.035682004,-0.01592177,-0.080480136,0.021676883,0.026066944,-0.040458195,-0.010419367,-0.019513447,0.063239895,-0.034497514 +2.7.8.21,"beta-Linked glucose residues in simple glucosides, such as gentiobiose, can act as acceptors. In the presence of low concentrations of acceptor, free cyclic 1,2-phosphoglycerol is formed.",384,0.99999994,-0.011093327,-0.0046488536,-0.0744755,0.06975227,0.042050067,-0.01180924,0.08404254,0.03922565,0.07664959,0.0069859414,0.05711016,0.027036043,-0.0753258,0.034619257,-0.038141377,-0.032288752,-0.02122086,-0.019439885,0.029691586,0.05536853,0.055902023,0.015349545,0.003914626,-0.0008439279,-0.0061772643,-0.049449757,0.0049906555,-0.040310107,0.012114685,-0.040854104,-0.035847183,-0.011332419,0.03193942,0.024734478,-0.020424172,0.08119491,-0.03131495,-0.038340878,-0.021049706,-0.037862193,0.08255658,-0.02430718,0.014271787,0.033337064,-0.042311296,-0.04097212,-0.03593624,0.025195543,0.04819765,0.007829636,-0.03560419,-0.05012691,-0.02121015,0.044077232,-0.019409616,0.03311945,-0.07778324,0.014339959,0.013460709,-0.048602007,-0.011503291,-0.00022190943,-0.034982596,0.012451753,-0.07719114,-0.07472592,0.020913113,-0.09661168,-0.041675497,0.004863596,-0.005533956,-0.023298455,0.05534278,-0.005246655,0.034382164,0.0812102,-0.077780105,0.054252554,-0.001826362,-0.0042484505,0.03144634,-0.051991902,0.086940385,0.045759674,-0.054158393,0.02714323,0.04097803,0.034541417,0.04860538,-0.011703373,-0.009478048,-0.03364363,0.072920516,-0.0017266514,0.02161784,-0.042527836,0.07919806,-0.059571024,0.037878036,-0.015207629,0.002114316,0.04507388,0.06628629,-0.013400858,-0.08183778,0.11587456,0.005981513,-0.028532866,0.025884595,0.0033853836,-0.051982127,0.021357985,0.11223259,0.013922201,-0.07043826,0.011613943,0.004295305,-0.08399277,-0.02584104,-0.023740025,-0.038807154,-0.09841574,-0.00040656517,-0.0595289,-0.05072345,0.14548805,-0.048055686,4.2495068e-35,0.05048253,0.049565952,0.024062617,-0.067886055,-8.454691e-05,0.014751679,-0.07973182,-0.055850197,-0.007793075,-0.041046947,-0.12232177,-0.018478762,0.007968567,0.11142908,-0.0027537022,0.01483753,0.015346793,0.047520977,0.1624589,-0.04111067,-0.054191798,0.04057594,-0.03951977,-0.074258275,0.030442456,0.10733337,-0.03379743,-0.006423162,0.017729305,0.0056422655,0.09980003,-0.023769418,-0.053607255,0.05665893,0.060345117,0.06305013,-0.031346392,0.028232655,0.0040131193,-0.02247862,-0.014849445,-0.010077859,-0.01110614,-0.012048095,0.10439186,0.008875946,-0.058969703,0.013040406,0.0155202225,0.086974405,-0.02225472,-0.017773738,-0.067072295,0.07000926,-0.021463525,0.060463663,0.030770319,-0.019178435,-0.0538272,0.011436406,-0.007726474,0.12432783,0.0019957828,-0.05846656,-0.05793035,0.034301024,-0.1255878,-0.044969805,-0.06307351,-0.008637799,0.00042529945,-0.06183028,0.038683392,0.036487103,-0.006418961,-0.05019319,0.040369686,0.0038921167,-0.0037537962,0.012950151,0.048701826,0.0077982317,-0.020562097,-0.017677655,-0.06441324,0.022079412,-0.029293505,-0.06144508,-0.055845816,0.012810042,-0.0010084438,0.033489104,-0.051057387,0.026787473,-0.002225199,-2.4546456e-33,0.11380146,-0.089822516,0.10898019,-0.027182985,0.027243389,0.013429309,-0.012174977,-0.106401466,0.08988758,-0.017475791,0.02394224,0.06514614,0.024073252,-0.016991867,0.011356674,-0.021354035,-0.053756222,0.1167773,-0.033902075,-0.05754058,-0.012751618,0.06754136,0.014604988,0.016438667,0.046574205,-0.024208616,0.018336488,0.05397036,-0.0017076682,0.023041574,0.006149886,0.01021636,-0.051726956,-0.11406672,0.052890804,-0.041811287,-0.1045179,-0.021889651,0.0362901,-0.009283626,0.015273933,0.05462748,0.06522492,0.0096399225,0.13243699,0.028868286,-0.008355106,-0.045700956,-0.013940533,-0.056837548,-0.04819301,-0.013744949,-0.042335127,0.029921813,0.0851122,0.123186104,-0.0017074052,0.07570168,-0.03271184,-0.033078518,0.00782298,-0.020575674,0.01963939,0.015609108,0.049691852,-0.013388914,0.03851915,-0.013613187,0.089744344,0.08355703,0.030776162,-0.031495865,0.009862898,0.059958186,0.07682118,0.051439706,-0.1496109,-0.06435403,-0.022803476,-0.09583846,-0.017778886,0.09110482,-0.00462377,-0.071953885,0.007263928,-0.10004169,-0.021219093,0.008036888,-0.055170357,0.051047694,0.0045751324,0.0023811113,0.012651084,0.05205038,0.07017097,-3.2868453e-08,0.057912406,-0.030174887,-0.048282005,-0.059248548,-0.056203093,0.012588853,-0.017081017,-0.033222612,0.0006683538,-0.021330338,-0.04998741,0.08592497,-0.014082677,0.012792643,0.026126215,0.06961457,-0.08005847,-0.019608349,-0.049239177,0.00972927,-0.043761052,0.024836812,-0.049049508,0.059219215,-0.035449993,-0.09734307,0.056157283,0.016985824,-0.09405495,0.052456558,0.014135388,0.0783037,-0.06213149,-0.03450749,0.009313484,0.013754514,-0.04536666,0.028728725,0.004816786,-0.0055501736,0.045245722,0.0022694545,-0.019538779,-0.0018674395,-0.08206402,0.04116433,0.013240878,-0.003120598,-0.095159166,0.026696155,-0.010508538,-0.00032949448,-0.0699782,-0.060575865,-0.09766215,-0.030758554,-0.028964471,0.021037623,-0.010259442,-0.06746666,-0.048311025,0.0127180405,0.14462274,-0.02466493 +2.7.8.23,"Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.",384,1.0,0.0070043015,0.0269166,-0.08575103,-0.027925715,0.0084910365,0.027600117,0.015234968,0.0029556267,0.07852081,-0.000898514,0.019313734,0.025411243,-0.06808298,0.027442988,-0.014729988,0.07383688,-0.100882754,0.07708233,0.010691424,0.058722954,0.06359276,0.019874467,-0.023706013,0.07880539,0.009868311,0.049194995,0.09674407,-0.01353774,-0.04415459,-0.054002073,-0.007615305,0.041598648,0.12145318,-0.056806877,0.029715424,0.080609955,-0.050019227,-0.09568054,0.1243673,0.0018550474,0.022535322,0.0035605347,0.032252654,-0.01768725,-0.039119206,0.026301013,-0.022493778,0.024012959,0.036003105,-0.037073176,-0.010650463,0.032809656,-0.09284332,0.05787317,-0.030050159,0.06311816,-0.045507014,-0.017085953,-0.037625886,-0.053489685,-0.0064654364,0.040794447,0.06602936,0.1171983,-0.0012619515,-0.0379443,0.017117886,-0.0047175884,0.05345103,0.005018606,-0.027212244,-0.043070674,0.03898139,-0.07153695,0.04187943,0.011259631,0.040517107,0.0027172128,0.008880419,-0.052762076,0.02014835,0.0067808717,-0.036701124,0.081262164,0.021617318,0.0072581274,-0.010967607,-0.01831532,0.016472818,0.006977964,0.011413418,-0.03276205,0.06669903,-0.060520552,-0.013301102,-0.030980477,0.07235133,0.012226211,0.017763868,-0.024514005,0.018925045,0.059105616,-0.0358427,-0.07107902,0.008515913,-0.008435068,0.012079285,0.04281678,0.014305889,0.050846208,-0.042653516,-0.056253225,0.0723556,-0.04444444,-0.1114044,0.07780762,0.01922,-0.052730206,-0.048866894,-0.04634079,0.021619502,-0.06930933,-0.018280147,0.04289078,-0.07666062,0.011431706,-0.08404217,-6.3671634e-34,0.022954809,0.0023746137,0.053079773,-0.03939343,0.04011356,-0.056871634,-0.065962754,-0.07653834,-0.07190698,-0.08060445,-0.11603285,-0.02358503,0.052131653,0.04522607,-0.035380445,-0.040802665,-0.08725318,0.07522015,0.054974593,0.056743093,-0.005105197,0.0439355,-0.011062215,0.04490119,0.002318845,0.036412194,-0.032306433,0.0074647106,-0.00655523,-0.004622513,0.054282043,-0.009306781,-0.031040464,-0.010595221,-0.02649861,-0.04225191,-0.0664402,-0.08569365,0.024524704,0.03690737,-0.022104772,-0.04969591,-0.027443381,-0.045230627,0.05805654,-0.04850145,-0.05395848,0.080175504,-0.01896484,0.06971567,0.02534517,-0.07611733,-0.036869533,0.047952145,-0.0648686,-0.046938848,-0.058343936,-0.024464872,0.06538756,0.082879856,0.0026149645,0.1089689,0.0025712275,-0.022714216,-0.009327761,-0.028378604,-0.06276379,-0.046088237,-0.007302041,0.036458105,-0.034753714,-0.023251869,-0.050416067,0.062225975,0.0114177875,0.031643853,-0.01828507,-0.047101755,0.01826805,0.064172335,0.03370982,0.029693453,0.07679945,0.015625076,-0.00523367,-0.020043446,-0.02810794,-0.044191055,-0.093724094,0.098190136,-0.036329288,-0.04787606,-0.03803646,0.058871515,0.027222553,-2.5386448e-33,0.14096642,-0.13685054,0.056600157,-0.057555545,-0.05061889,0.045588624,0.0010997064,-0.10644967,0.085789524,0.0316824,0.008806017,0.012340175,0.018784253,-0.06669497,0.055759646,-0.10262825,0.07397705,0.06757795,-0.016086997,-0.0036925608,0.07243227,0.011256536,-0.00867911,0.014534581,-0.045837346,-0.019655878,-0.0050283875,-0.017305583,0.0055860686,0.099271506,0.038156696,-0.002688346,-0.06615788,0.045200836,0.006534288,0.11397113,-0.03585834,0.030204764,0.035023086,0.013272219,-0.029923607,-0.031142646,0.026183756,-0.044488437,0.039249744,-0.0047048517,-0.055082038,0.062642515,-0.0025723334,0.00803245,0.067753315,0.033092316,0.00890389,-0.03282946,0.0062872977,0.06233754,-0.024332467,-0.014441807,0.037533898,-0.06481998,-0.054922353,-0.01156151,0.028025433,-0.017724426,-0.057213478,0.010284372,-0.004462452,-0.0064892946,0.054729413,-0.09424436,0.05849085,0.118912086,-0.022684071,0.066917494,-0.0037098033,-0.031906087,-0.07560235,-0.09608183,0.07386136,0.008162774,-0.07249533,-0.012155136,0.06778715,0.027358076,-0.057106182,-0.08239919,0.017083447,0.059636522,-0.002705745,-0.018608723,-0.0061305966,-0.039726622,-0.016281683,0.012679787,0.0689898,-3.8751065e-08,-0.00417794,-0.057043754,0.06581184,0.009014955,-0.025366817,0.020779602,0.006962615,-0.020501234,0.034964517,-0.05080919,0.044529293,0.058708932,-0.034789946,-0.06916039,0.049547005,0.04635939,-0.03362253,-0.014069245,-0.009924214,-0.04697758,-0.027622113,-0.04964061,-0.07045785,0.060058217,0.020992616,-0.07920381,0.07108622,-0.010445566,-0.07929262,-0.026423272,0.0801752,-0.01893571,-0.04309731,0.030081594,0.06009877,-0.08426339,-0.07774961,-0.040808648,-0.0013345035,0.045662727,-0.0019715086,-0.02067111,-0.028095676,-0.011637934,-0.041705865,0.07521944,-0.03958581,0.06499792,-0.0840337,-0.026096478,0.12315891,0.015653508,-0.05486964,-0.014710935,-0.09491925,-0.021084566,0.019295238,-0.090694875,0.025021194,-0.042285185,-0.009028753,0.049180344,0.19674723,-0.010881769 +2.7.8.24,"Requires divalent cations, with Mn2+ being more effective than Mg2+.",384,1.0,-0.0029130748,-0.08640647,0.030621443,0.06463901,0.041124105,-0.079670504,0.019003414,0.058724828,-0.06367168,0.014992875,0.01018799,-0.0034936934,0.071998745,0.05136174,0.023450049,-0.013548497,0.052240364,0.02726688,-0.023203868,0.109141625,0.11632764,-0.012301189,0.030192953,-0.032180693,0.0135995075,0.0896576,0.014160586,-0.032925136,0.057208776,-0.019463444,0.00020718983,0.08929985,0.027884878,-0.07835441,0.032297123,0.05425227,-0.04448205,0.015902076,-0.05792955,-0.05599118,-0.025681555,-0.0040053455,0.15105116,-0.032029387,0.0020384025,-0.112715304,0.069305025,-0.11010688,0.003950777,0.030521428,-0.026871238,-0.017803261,-0.04107241,0.047604553,0.012571106,-0.0019005548,-0.13247097,0.021293402,-0.064486936,-0.020770485,-0.049571235,0.007201051,-0.03758622,-0.02508326,0.09803066,0.009108625,0.028154505,-0.026542556,0.02326273,0.051407542,0.064475566,0.024881188,-0.02327743,-0.03710484,-0.002550612,0.054074787,0.0931876,-0.07449502,0.078636914,0.061275583,-0.05169726,0.024883201,0.07173922,0.047811575,0.055381924,0.046436563,0.038917094,-0.03180319,-0.026776575,0.030004611,0.07291838,0.1038161,0.020257667,0.057311308,-0.04311263,-0.0040487796,-0.055138815,0.04451195,-0.028702809,0.016748594,0.008148031,0.08249295,-0.112868175,-0.008122987,0.013755114,-0.03780916,0.06799975,0.0194726,-0.024937177,0.06816442,0.12366327,-0.0025790406,0.015107657,0.056575175,-0.0027201495,0.05399794,0.04350472,-0.05270945,-0.012378914,-0.028549619,0.020913374,-0.00051282265,-0.06837947,0.006279093,-0.053434122,0.02317146,-0.0044963686,1.8797358e-33,-0.024905445,-0.009655127,0.050088767,0.014478683,-0.032635674,0.03327265,-0.09610287,-0.059039045,0.039569654,-0.06734746,-0.13945758,-0.038246725,-0.01049024,0.03710817,-0.03695721,-0.115281306,0.001491491,0.0064137825,0.13572548,0.009425395,-0.004836837,0.05308744,0.01688474,-0.028042538,0.014348261,0.06878729,0.1259936,-0.033449292,0.018405216,0.007868986,0.0783246,-0.09745327,-0.02686159,0.04876844,-0.012308973,0.044250965,-0.108639136,-0.017565677,-0.0063044103,-0.026142225,-0.049768668,0.07470929,-0.06741203,0.082275465,0.052345965,-0.073573045,-0.013565025,0.024397405,-0.07915323,0.027878402,0.06238337,0.074420504,-0.020263316,0.041370124,-0.061883755,-0.001925918,0.032558423,0.010940686,0.037232947,0.077572204,-0.05086498,0.026423955,0.08385476,0.06365982,0.05848417,0.042210504,-0.07273863,-0.05578042,-0.0013464956,0.011092579,0.008123257,-0.10309613,0.10317372,0.010201598,-0.002315982,-0.014097281,-0.004107515,-0.035522766,0.03642436,0.005196688,-0.032928232,-0.03833824,-0.008087514,0.0154257575,-0.11855482,-0.031837117,-0.012511539,-0.043398984,0.014727902,0.027561173,0.06271155,-0.015988471,-0.022501584,-0.03336768,-0.019575208,-2.3733846e-33,0.017792204,-0.01815012,-0.023598608,0.008200015,-0.109295405,0.012860607,0.02631615,-0.15748926,0.042794146,-0.0071137543,0.06652154,0.0344514,-0.04401059,-0.04138651,-0.024023766,-0.022684675,0.012269243,0.019871898,0.060744215,-0.0024178813,0.0051156287,0.114168525,-0.0360833,0.07995835,0.01377847,0.038904484,-0.027768463,-0.032074176,0.024339352,0.01363712,0.03628663,0.0022506034,-0.05414649,-0.087819375,-0.04423838,0.0128625585,0.00030579776,-0.041779324,-0.058516745,0.029427316,-0.033127856,0.021461368,0.03851728,0.06370743,-0.017103573,-0.017853072,0.04444274,-0.015132588,0.044875234,-0.0041611763,-0.012028861,-0.061758034,-0.07205827,-0.06732771,0.03972914,-0.04708285,0.017679395,-0.03761323,0.020574355,-0.016227843,0.032920264,-0.03685967,0.02429074,-0.10479852,-0.011579975,0.047914922,0.030060787,-0.00071206235,0.023520926,0.020652773,0.042422898,0.07325262,0.10539594,-0.01431552,-0.027752412,0.037000597,0.002131497,-0.04783816,0.0028276143,-0.14731964,-0.03460162,0.027692024,0.0037436306,-0.06893649,0.02980456,-0.09102582,0.010270951,0.053320285,-0.021795036,0.03918719,-0.017434273,-0.08862588,-0.0109623,0.008974954,0.03548877,-2.3451651e-08,-0.024760427,-0.070385,-0.042181503,-0.040481836,-0.03250389,0.037197925,-0.034743566,-0.010390901,0.077644385,0.018615095,0.052467242,-0.00057009794,-0.010476201,-0.0066847433,0.05463802,-0.008122448,-0.0124876425,-0.02334244,-0.105131246,-0.06508379,-0.086474136,-0.017018426,-0.11134657,-0.017365346,0.017903076,-0.00892933,-0.038340665,0.045482375,-0.008274959,-0.027867712,0.05032313,0.0012725454,0.024646068,-0.022307312,0.007398386,0.056681443,0.016476488,0.016088594,0.008957978,-0.08122727,-0.12438494,-0.03027769,0.06360944,0.035424847,-0.06247722,-0.028255105,-0.025091525,0.05961432,-0.019334521,0.04664844,0.053724784,-0.054212343,-0.017523462,-0.06086443,-0.025862303,0.021925412,-0.024175586,-0.004133658,-0.015634332,-0.043027412,0.027649868,-0.057668805,-0.010056271,-0.058502052 +2.7.8.25,"ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (gamma-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase [4].",384,1.0,-0.0630692,-0.017340219,-0.042680867,-0.072865106,-0.014850127,0.009019583,-0.018757988,-0.00025698665,0.033596575,0.05868642,0.09377201,-0.05948633,-0.0899026,0.027409982,0.03218632,-0.035217267,0.014601387,0.0446112,0.008094584,-0.063995436,0.06558006,0.042931624,-0.08874025,0.01906626,0.038370293,-0.008987295,0.041705605,-0.0124603445,-0.061899673,-0.08455305,-0.108375505,-0.08330152,-0.019277377,-0.03442352,0.013596787,0.10376422,-0.1127842,-0.10623976,0.058732048,-0.03572616,0.08099065,0.007868347,-0.0077874484,0.018053025,-0.06304317,-0.0286215,-0.0010354806,0.04384836,0.056993734,-0.06430046,0.021270778,-0.02512257,0.00310897,0.006729672,-0.056805573,0.030375121,-0.046468474,0.0023937398,-0.032349974,-0.0047910823,-0.0485299,0.04581708,0.0008286018,0.016224604,-0.02123395,-0.05896014,0.069566935,-0.02155602,0.005844543,0.02419079,-0.047873504,-0.036066197,-0.0025582402,0.010436811,0.037276335,0.05618765,-0.005227813,0.039202493,0.014994427,-0.0014578109,0.06135722,0.035397638,0.06446533,-0.018923657,0.021126641,-0.062822066,-0.0108193355,0.05856632,0.021627977,-0.05023841,0.046266615,0.0077823265,0.0006802145,0.0014945812,-0.036954664,0.09485898,0.008960961,0.019942446,0.0010844413,-0.025080254,0.044987604,0.13202414,0.024321182,-0.07094691,-0.005879429,0.048390526,-0.034278814,0.0881423,0.012497465,0.06616883,-0.034902442,-0.010299839,0.02961673,-0.05983214,0.024576232,0.10434323,-0.096351534,-0.030140275,0.010207526,0.004183889,-0.001762021,-0.08206216,-0.011319984,0.061551567,-0.037110638,0.053357843,-0.111493774,2.696382e-33,0.04368755,0.030058855,0.046593413,0.036326174,-0.0021319094,-0.027770039,-0.08713031,0.010045992,-0.038006615,-0.06694563,-0.05651004,-0.034422725,0.07264331,-0.035751346,-0.015239206,-0.031125613,-0.030797303,0.026625691,0.12024833,0.041172843,-0.014101988,0.07237973,-0.0015260963,0.002689379,0.019989643,0.121576525,-0.071415134,-0.062940076,0.0012255451,0.024709582,-0.023135597,-0.053544637,-0.074950494,0.02909651,-0.027076662,-0.07174467,-0.08819194,-0.04985951,0.028553491,0.044688087,0.04924346,0.0151584875,-0.0049161906,-0.016557328,0.07767787,-0.03548844,0.019926306,0.02836327,-0.01000858,0.07280478,0.04531871,-0.0844484,0.03887294,-0.012553037,-0.102549054,-0.004600438,-0.025785144,0.012092677,0.08207628,0.018004118,0.068040155,0.12272689,-0.012464346,-0.021441137,-0.004153057,0.04652925,-0.12587115,-0.10815354,-0.018598566,0.082291715,-0.054803338,-0.06777951,0.03627923,0.027177608,0.03529421,-0.07014577,0.0041761985,0.04495261,-0.022779314,0.096119516,0.020599836,0.0033186781,0.003414934,-0.006425638,0.019852037,-0.038978107,0.0035844925,0.015097189,0.012160907,0.045983143,0.0900973,0.011171615,-0.009663096,0.0571865,0.028388424,-4.4306748e-33,0.17644449,-0.10603055,0.05804249,-0.09166203,-0.09299518,0.030420076,0.026711991,-0.05835871,0.023435382,-0.06405309,0.046108235,0.007545091,-0.0055843014,-0.0923355,-0.0004558835,-0.029154414,-0.043030523,0.07155222,-0.0045335423,0.030671878,0.061840024,0.060765292,0.049774375,0.015710875,0.048223462,-0.07852785,0.07168285,0.035214435,0.05469158,0.0104824435,-0.009676886,-0.0024845134,-0.04534362,0.040090226,-0.08549134,0.008581832,-0.049088035,0.04559375,0.015494084,0.06377151,0.054262105,0.090505965,0.07171074,-0.039275605,0.047967006,0.09742447,-0.022689173,-0.021742994,-0.027016092,-0.055468813,0.04179808,-0.025649387,-0.07937326,0.014405788,0.009485027,0.07636105,-0.015996441,-0.020171965,0.0077648945,-0.047697585,-0.08669686,-0.02448773,0.052691694,-0.03423655,0.050743394,0.10361234,-0.0306631,0.017864646,-0.01526127,0.007920052,0.0027397436,0.031748835,-0.010969965,-0.029311413,0.060262576,-0.0071953023,-0.0890686,-0.0022744199,-0.026837619,-0.077653624,-0.03504077,0.032542318,-0.029767213,-0.04580029,0.028896187,-0.044542145,0.029887332,0.11492552,0.006528438,0.00020354218,0.0011260844,-0.012647049,0.046272993,0.06495356,0.0808809,-5.4720967e-08,-0.019022785,0.0225883,0.02451146,-0.03139779,0.0118135465,0.07839506,-0.0036309154,-0.019407077,0.07327362,-0.025534676,-0.02648347,0.031995703,0.03180018,0.024859246,0.010047456,0.07934763,-0.049080204,0.049053684,0.009208276,-0.026302721,-0.047015265,-0.049350943,-0.04680337,0.1149498,0.013200112,0.0032155898,0.058770034,-0.0156929,0.0139330365,-0.08591689,-0.043357447,0.010194627,-0.028440427,-0.001302598,0.016079994,-0.07182702,-0.06469166,-0.04019792,-0.061285384,0.0323916,-0.022377264,-0.029019812,-0.04117491,0.013105557,0.049716968,0.016500315,0.05163694,0.0052711223,-0.07713337,-0.033240538,0.07080573,-0.012901355,-0.045249876,-0.0886824,-0.0580198,-0.06807114,-0.03961579,-0.09482216,-0.039475136,-0.039270423,0.025790015,-0.02071297,0.10787967,-0.040424522 +2.7.8.26,"In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. CobS catalyses the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with alpha-ribazole to yield adenosylcobalamin.",384,1.0,0.027409067,-0.039880343,-0.13323157,-0.041154284,-0.020134188,0.02853887,0.0046279687,0.018955216,0.054299008,0.0171657,0.014891939,-0.02562112,-0.05512156,0.03883606,-0.0027553467,0.017357286,-0.061824076,0.032530554,-0.008092799,-0.07045942,0.016799811,0.06659675,0.028811025,0.006989865,-0.03450686,-0.009034123,0.024433699,0.033568565,-0.011362982,-0.07107968,0.011155187,-0.046929095,0.08722587,-0.05165662,0.07785466,0.075686194,0.007049948,-0.08194006,0.049390085,0.049865067,0.052070577,0.058424074,0.03550712,0.03188715,-0.05173851,0.019859249,-0.021053506,0.07918793,0.010870606,0.0042729005,-0.038025744,-0.041466773,-0.0602219,-0.04174791,0.006405947,0.10586346,-0.07706385,-0.05212549,0.032620955,-0.031247037,-0.0073886006,-0.03941142,0.012757133,0.059581026,0.03574926,-0.028200276,0.06929667,-0.06807337,0.019393869,-0.0048693516,-0.028268743,-0.038479384,-0.04142491,-0.009700537,-0.044336308,0.056344718,0.029904082,-0.04892852,0.023453528,-0.053936027,-0.041128393,0.018686915,0.030130321,-0.0039204606,0.025674468,-0.04466899,0.0068603936,0.040645123,0.044662517,0.05975252,0.042469136,0.007738851,0.13160406,-0.051245224,0.0019967677,-0.019269241,0.098162994,0.097319506,0.015637254,-0.059867255,0.0030372397,0.05974932,-0.047898248,-0.04787459,0.07993642,-0.040831234,0.05307285,0.13168226,0.025684636,0.04066083,-0.06419109,0.0587035,0.054056823,-0.033068564,-0.0019238252,0.030222608,0.016915144,-0.006734566,-0.0218033,0.00024508906,-0.0005703922,-0.06354778,0.032921027,0.0095893415,-0.01832016,0.020359429,-0.058734898,5.6954843e-33,0.045591522,0.03342516,0.04593907,0.018438824,-0.031732384,-0.018794991,-0.0688439,-0.04116229,-0.050038908,0.032553073,-0.06761947,-0.017876899,0.06259352,0.016483149,-0.03249101,-0.075186044,-0.062263925,0.016749302,0.023935834,0.1254937,0.010167304,0.03545837,0.009063384,0.08424961,0.00010181738,0.016292755,-0.042976648,0.0826998,-0.026104528,0.009696399,-0.05420918,-0.005673415,-0.14366142,-0.0011191985,0.05197315,-0.06710241,-0.06632429,-0.015637986,0.025083514,0.094702125,-0.036909837,-0.014306616,-0.06432109,-0.006013804,0.046141557,-0.060936708,0.0072918944,0.09288454,0.015281744,0.03949815,6.537588e-06,-0.009153405,0.07240087,-0.011293469,-0.022938209,-0.026719125,0.004078763,0.0055303043,0.03602594,0.09274815,0.014498275,0.06883994,-0.037452575,0.0524406,-0.028781122,0.016005434,-0.024483249,-0.12798786,-0.0020011987,0.003290744,0.03934293,-0.041651327,0.049704503,0.07569285,-0.01941123,-0.0067746146,-0.034402322,-0.13578893,-0.016998947,-0.034062736,-0.0017267328,0.0030414297,0.06555853,-0.04715539,-0.010676932,0.01948274,-0.008554124,-0.044934474,-0.07165327,0.013773785,0.042627282,-0.016551415,-0.01773631,-0.021881249,0.055015977,-5.4776027e-33,0.14716084,-0.063168064,0.00062555325,-0.1428516,-0.09903477,0.031038146,0.047823012,-0.12396411,0.08489212,-0.08550271,0.07822365,0.013575886,-0.014437928,-0.03295505,-0.021272724,-0.060334694,0.042887572,0.10464504,-0.03688751,-0.044866245,0.035601158,-0.0053314646,-0.041957486,-0.0008323357,-0.028395263,0.028026372,-0.0010890948,0.07822063,0.0421722,0.041581757,-0.0463414,0.048505396,-0.040195733,0.009975761,-0.04671746,0.059723955,-0.011151031,-0.00010616549,0.019160166,-0.035346936,-0.016422361,0.07149201,-0.030473514,0.015900675,0.034703135,0.0786327,-0.015076987,1.9920772e-05,-0.054449417,0.003816368,0.014923679,-0.019369282,0.0057556215,0.03430594,-0.020666538,0.06226813,-0.021738566,-0.057990063,0.043346774,-0.07476464,-0.00021066685,0.025274402,0.066737615,-0.036160477,0.014384529,0.01926721,0.03678462,0.054219037,0.024635274,0.026725296,-0.047252182,0.05980869,0.018200208,-0.016776664,-0.057037685,0.015918871,-0.072948344,-0.06763589,0.02630006,-0.08807651,-0.03780699,0.03697747,0.0015912756,0.011810958,-0.01579226,-0.006106336,0.03085563,0.045771684,-0.05379513,0.06103757,-0.048014797,-0.08462641,0.020890132,0.080846936,0.04839236,-5.023364e-08,0.052248724,-0.03616887,-0.00031157568,-0.07147572,0.09019172,0.10542742,-0.07769108,-0.049746003,0.14239088,-0.05449932,0.0019984343,0.10236605,0.01672268,0.046791047,-0.04639385,0.07492685,-0.049917664,-0.06703169,0.018680679,-0.09172342,-0.082212985,-0.03410377,-0.06928894,0.058709554,0.028984569,-0.044864926,0.03588893,0.09809753,0.022194987,-0.03092676,-0.040176272,-0.033068772,-0.05132272,-0.036252737,0.05145358,-0.012459742,-0.04215331,-0.01327978,-0.011616813,-0.0005839526,0.005671669,-0.010223751,-0.09329779,0.034820035,0.004869384,0.02909021,-0.06940243,0.0708601,-0.042833287,-0.046312526,0.045097683,0.035916615,-0.04975737,-0.0101324115,-0.06767067,0.037651986,-0.033468623,-0.08467274,-0.042842902,0.022343973,-0.046663534,-0.00019097902,0.07853098,-0.15340301 +2.7.9.2,A manganese protein.,384,1.0,-0.09663861,-0.06299021,-0.045147665,0.072824284,0.04954634,0.014303665,0.11178869,0.09074447,-0.05162435,-0.020063119,0.09727795,-0.03917234,0.04301289,0.057707373,-0.025666233,0.0061459364,-0.019172331,-0.010370138,-0.053310655,0.018966375,0.06177439,0.049997054,-0.0031859446,-0.060345974,0.034928255,0.058279477,0.08417482,-0.048358697,-0.035133854,-0.05035579,-0.038758986,0.020150274,0.05915677,-0.09033603,0.08497073,0.02290973,0.0255026,-0.054073628,-0.020732466,-0.032350395,0.033876047,0.049593892,0.11939896,-0.035811536,-0.032490473,-0.02649727,0.09310748,-0.030694013,0.06894733,0.06315312,-0.037575677,-0.08494164,0.01697824,0.033525858,-0.0059301383,-0.010851664,-0.07594635,-0.009026815,-0.047946498,-0.01837365,-0.008367982,-0.0095647,-0.001975591,0.0028956789,0.09591812,-0.05149584,-0.01237594,-0.009553206,0.07226905,-0.0075519476,0.053564176,0.0050585014,0.00038824635,0.067941174,-0.034024123,0.035603695,0.08687229,-0.03302815,0.088202104,0.016307464,-0.0709176,0.05168447,0.0456402,0.035652556,0.06894702,0.102524996,0.03250252,0.021383028,-0.045869965,0.038190577,-0.016506936,0.037179373,-0.034178343,0.006000159,-0.09288611,0.012837714,0.026433242,0.029118432,-0.040658925,0.08008494,0.07133362,0.046538573,0.020651659,-0.09825604,0.007115136,-0.06547211,0.013258533,0.08298052,-0.01191271,0.020367302,0.04801652,0.018234309,-0.015213628,-0.0062055294,0.014535741,0.04860413,0.090129584,-0.029528834,-0.059974384,0.023694346,-0.0090633575,0.0075899,-0.043568417,0.015179763,-0.03963546,0.018701594,-0.08703571,-3.7695084e-33,0.035877958,-0.03547822,0.036834367,0.0077236765,-0.020146724,-0.0077136583,-0.061132524,-0.050083317,0.06556076,-0.052395876,-0.107987456,-0.013115432,0.017032055,0.0064041796,-0.023307556,-0.076999895,-0.048401207,-0.0112641305,0.10053478,0.00918922,-0.026775239,0.110579796,0.008685885,-0.038781695,-0.015670653,0.002180551,0.017537413,-0.10206197,-0.025090186,0.01847661,0.0059592472,-0.04206817,-0.067947745,-0.02644715,0.04406668,-0.04812387,-0.030597048,-0.068421215,-0.031035703,0.009765698,0.014453671,-0.0045753457,-0.13871326,0.069695085,0.037943833,-0.11564416,-0.04241495,0.025269723,-0.058728836,-0.045004543,0.021644166,0.006678729,0.10422264,-0.023492761,-0.07066159,-0.0281749,0.029151496,0.000103040096,0.0064906725,0.07224783,-0.017490907,0.02072535,-0.03728727,0.12435308,0.030998556,-0.029201033,-0.05089524,-0.1034311,0.0103349,0.0109314,-0.031850077,-0.14511447,0.08861145,-0.05773732,-0.070656486,-0.04067487,-0.049913976,0.0013390427,-0.019479623,0.07923568,-0.027989175,-0.03720384,-0.025674636,-0.033075485,-0.09481478,0.08749134,0.03365267,-0.10234803,0.0837319,0.00852565,0.087543994,0.0123557355,-0.020250367,-0.03460831,-0.050044704,2.0596018e-33,-0.0047414685,-0.039091352,0.018185038,-0.0035101508,-0.049470995,-0.020958642,-0.012264271,-0.030692702,-0.02075034,-0.041225713,0.09125038,-0.04251435,0.02138071,-0.035701033,0.037448604,0.09803854,0.040566206,0.08780063,0.10685653,0.027548982,-0.03691228,0.037946858,0.030757751,0.112880185,0.007431402,0.06801491,0.0019509483,-0.03484474,-0.030135686,0.041180365,-0.024462484,-0.029501036,0.011439493,-0.091363326,-0.033926975,-0.011020426,-0.0030102842,-0.055995844,0.018707868,-0.00020715356,0.030397095,0.011309917,0.027771482,0.13052186,-0.034796968,-0.01111521,-0.022647357,0.013630413,-0.050968155,0.009768878,0.0080511905,-0.04874546,-0.01645146,-0.07300009,-0.03883713,-0.019536372,-0.051890593,0.026119003,0.049397517,0.040635884,-0.014042602,-0.02090756,-0.0010017642,0.048941337,0.030418577,0.08637883,0.058056,-0.0140918,-0.022885993,-0.027290514,0.08083324,0.060167894,0.09138895,0.060835414,0.06172536,-0.052551392,-0.0036753064,0.022378309,-0.046893317,-0.055861235,-0.045944482,0.033637565,-0.037689112,-0.08980221,0.042674176,-0.010516477,-0.00874565,0.06924718,0.011880079,-0.0005419453,-0.0030905388,-0.05136686,-0.10469859,0.06511332,0.0537289,-1.3036207e-08,0.026676008,-0.10003514,-0.03140691,-0.0572783,-0.070536695,0.033174545,0.02654765,-0.050823677,0.054066315,0.011043831,0.06672901,0.08628851,0.0044985865,-0.016525745,0.0020378653,0.027722107,-0.010228852,0.057096764,-0.050628472,-0.020615062,0.032482725,0.014285993,0.015410413,0.04003464,-0.007540053,0.027143223,-0.05058628,0.11605983,0.003426019,-0.05127224,0.028340945,0.030993607,-0.042690393,0.01868831,-0.044309583,0.063774824,0.05128403,-0.009837006,-0.07615713,-0.0052363514,-0.10958791,0.025767868,-0.033141885,-0.004733511,-0.02235855,-0.036836985,-0.0423999,0.0620423,0.0049967207,-0.034791894,0.00020062648,-0.042916846,0.046374347,-0.056693394,-0.07281758,0.011007891,0.015511481,-0.050823756,-0.06476047,0.03219704,-0.032956112,-0.044506587,0.07754633,-0.041137137 +2.7.9.3,Mg2+-dependent enzyme identified in Escherichia coli,384,1.0,-0.07702919,-0.09014466,0.015437241,0.0628011,0.04698911,-0.038109645,-0.035663962,0.019812204,-0.044983543,-0.033400632,0.024309637,0.026795652,0.049897287,0.06062562,0.035156,-0.013123788,0.03106217,0.066813014,0.012734301,-0.017025655,0.13734485,-0.0016084114,-0.04686855,-0.022560311,0.013145953,0.041689016,0.11087503,-0.019344103,-0.0148006035,-0.00038366113,-0.029687373,-0.018320085,0.057659466,-0.09764947,0.091550365,0.03908177,-0.011038632,-0.022295581,-0.009899041,-0.12732193,0.012767979,0.036516014,0.111543216,-0.026722882,0.03338222,-0.11272504,0.097020924,-0.023188824,0.019168926,0.0058415667,-0.041825626,-0.02187965,-0.03733341,-0.016454427,0.07523702,-0.011551735,-0.10011837,-0.05642237,-0.028542386,0.0059443475,0.0066621015,0.016428793,-0.0045178034,-0.03202696,0.019100348,-0.001092158,0.064716674,-0.019477446,0.015094102,-0.051412683,-0.062234633,-0.034484845,-0.0020118805,-0.020868106,-0.025776505,0.0059351157,0.03665679,-0.04905263,0.048930313,0.03278575,0.017350333,-0.069592565,0.07473393,0.047843404,0.0065527386,-0.024495013,0.06358397,0.08105533,0.010307593,0.08917569,0.08621182,0.024817893,0.06140273,0.0049093114,-0.014594644,-0.0057959673,-0.087430626,0.018574566,-0.0076392177,0.0063128727,-0.009141933,0.060530413,-0.0030000738,0.017461361,0.0043597245,-0.0043868064,-0.002764872,0.059189588,0.05646246,0.012065921,0.11230716,0.053262353,0.006951293,0.051776472,0.01016069,0.041143082,0.012086449,-0.09856221,-0.053620256,0.010162942,0.040471677,-0.033061754,0.011540241,0.02902593,-0.047308564,0.032238774,-0.063632734,2.568283e-34,-0.030711344,-0.018554823,0.05619965,-0.002925465,-0.013399316,0.0038924818,-0.030408632,-0.0029019418,-0.014894558,0.010696533,-0.09674224,-0.058862764,-0.017111082,0.0270261,0.007663557,-0.031779606,-0.002748815,0.020853225,0.10807267,0.04312628,-0.040322937,0.08411627,0.033564672,-0.053283993,0.0511235,0.102820285,-0.0111501645,-0.08946822,0.058424614,0.016249642,0.0504548,-0.103209525,-0.053974528,0.05697748,0.0768265,-0.06688573,-0.020733302,-0.019017933,-0.023722794,0.008738779,-0.087855905,-0.0008092222,-0.058624692,0.03144473,0.013198442,-0.08692101,-0.026766945,0.031996693,0.010882878,0.068307824,0.05070033,0.038111318,-0.013564987,0.0033863527,-0.061249822,0.031951852,-0.009608393,0.093908794,0.07000609,0.0052415603,0.018098393,0.07375676,0.00030488407,0.03910687,0.063434914,0.008593075,-0.046428096,-0.09261355,0.017827913,0.16328767,-0.030458983,-0.061190505,0.038984247,0.02468161,0.025064908,-0.048507113,-0.04938587,0.030625552,0.05810729,0.03744309,0.014352741,-0.008543357,0.002188106,-0.017126985,-0.10740122,0.0054987585,-0.039265245,-0.036273297,-0.002570677,0.034846198,0.047225934,0.035770237,-0.04912913,0.05524752,0.009479378,-2.0229786e-33,0.05424649,-0.013423297,0.0758654,-0.10279511,-0.14717299,-0.0024786962,0.0027294836,-0.061204035,0.047861017,0.028103502,0.06971951,0.01246846,-0.005016861,-0.055763535,0.013005178,-0.054696564,-0.027902381,0.033145957,-0.043074768,-0.021190003,0.024067927,0.07096031,0.02426231,-0.0024532545,0.013311595,0.0334701,0.050725766,0.076876536,0.048377886,0.043261938,-0.014649308,0.09761857,-0.01714458,-0.06987756,-0.096278034,0.035597328,0.010586203,-0.025638599,0.0022672042,0.046432197,0.0041696406,0.1063915,0.022535065,0.06484799,-0.020217482,0.0031953664,0.011761718,0.042241983,0.07317461,-0.11407886,-0.049573928,-0.015530173,-0.0584674,-0.08036247,0.026797641,-0.06342944,-0.039020587,-0.021099005,-0.015385674,-0.012303286,-0.010403915,-0.054926425,0.063559406,-0.035296533,0.0063887243,0.034856,0.04428366,-0.012778183,0.028769864,0.053615097,0.047953714,0.0054488787,0.014625503,0.012043349,0.014519861,0.029760212,-0.089704536,-0.034336768,0.069665365,-0.08918933,0.01742568,0.07773824,-0.024536904,-0.015481704,0.0018956237,-0.1633061,-0.019070301,0.13787733,0.074359134,-0.040567257,-0.057221297,-0.050125,-0.08420627,0.006519243,-0.019396642,-2.124606e-08,-0.04559688,-0.12444262,0.014551046,-0.076135725,0.010348283,0.09524353,-0.12385466,-0.04216588,0.09299799,-0.013749101,0.032306332,-0.0059406064,-0.0696415,-0.028596861,-0.034349613,0.04303196,-0.029745562,-0.04231837,-0.025215743,-0.019812593,-0.009300639,-0.030661069,-0.108734146,0.016232572,0.026174158,-0.079726085,-0.060375143,0.06749493,-0.06424109,-0.008205189,-0.030956956,-0.034840606,-0.0024265638,-0.019292861,-0.053152815,-0.03589206,-0.04004493,-0.0150995925,-0.03084288,-0.06419385,-0.008181484,-0.038885724,0.024675366,0.0024457097,-0.030981183,0.034007195,0.013025729,-0.016078057,-0.043757852,-0.01090463,0.040379584,-0.07255702,-0.035736505,-0.020307126,-0.036458448,-0.0040953583,0.06061668,-0.06687149,-0.04834974,-0.075577654,0.03351689,0.012357914,0.06775808,-0.055125028 +2.7.9.4,"Requires Mg2+. ATP appears to be the only phosphate donor. No activity could be detected using GTP, UTP, phosphoenolpyruvate or diphosphate [1]. The protein phosphorylates glucans exclusively on O-6 of glucosyl residues [2]. The protein phosphorylates itself with the beta-phosphate of ATP, which is then transferred to the glucan [1].",384,0.99999994,-0.075249545,-0.016015328,0.002658738,-0.022013398,0.005392768,-0.028884737,0.05949247,-0.010607876,0.024760706,0.039806645,0.012936503,0.07397841,0.0037115656,0.058089945,-0.035221107,-0.05073343,0.038180295,0.045246158,0.03804948,-0.02257374,0.11836211,-0.0034934487,-0.007865435,-0.06884144,0.052304275,-0.029420065,0.086855404,-0.016911201,0.0038652723,-0.017173065,-0.14129137,-0.058951024,-0.004200862,-0.0319712,0.04366804,0.123766586,-0.025743201,-0.010489259,-0.02610028,-0.05028312,0.039436944,-0.080225065,0.039920796,0.018535253,-0.023904858,-0.058592733,0.04165877,0.030923279,0.021290846,0.009606756,0.03228724,-0.021555766,-0.014076141,0.020676017,0.023189537,-0.007634095,-0.10513054,-0.012271095,-0.009601374,-0.006281108,-0.050419994,0.010391941,-0.013706152,-0.024003806,0.03790767,-0.015710324,0.048503805,-0.045257907,-0.02126076,-0.019081784,-0.0006183725,0.03145966,0.058655843,-0.0030187631,-0.014802071,0.05760197,-0.03241263,0.02048922,0.049236402,-0.010633253,0.11971509,0.009973268,0.040757176,0.062058877,0.024112552,0.022132346,-0.033849,0.089673564,-0.038718414,-0.0008635894,-0.0156096285,-0.038078338,-0.025540661,-0.04453854,-0.04579961,0.00022309828,-0.03918855,-0.015601956,0.018617215,-0.020835148,0.008313566,0.062244903,0.0888716,-0.009449113,-0.034815837,0.060366474,-0.09060457,0.040726323,0.06023052,0.009506256,0.018819757,0.06729962,0.010917392,-0.022360351,0.01183024,0.060113773,-0.042135622,-0.086997844,-0.121911295,-0.007422365,-0.01706557,-0.018773735,-0.027777353,0.033473585,-0.08571369,0.08116528,-0.027586183,3.795175e-33,0.009799985,0.007307396,0.07739999,-0.040324133,-0.06978041,0.02868701,-0.02919844,-0.09080726,0.0068883616,-0.06760993,-0.0647261,-0.0221754,0.029916158,0.05171243,-0.04651459,0.06091764,-0.020591957,0.001368423,0.12845239,-0.03857159,0.018070111,0.06489024,0.03092556,-0.009279713,0.056401707,0.08457648,-0.085931554,-0.056431092,0.04679826,-0.01791211,0.030506268,-0.075112015,-0.06220702,0.0388698,-0.012743825,-0.04424259,-0.047190834,-0.06266898,0.05296598,-0.07026181,0.0046556927,-0.017893944,-0.0069619855,0.028802995,0.048947584,-0.08538077,0.017881459,0.012060935,-0.04922598,0.11425661,0.08040197,-0.020390326,-0.009945681,-0.026328098,-0.099434465,-0.0036523887,-0.013121424,-0.004783703,0.040091485,0.041977994,0.08684219,0.048453186,0.034366738,-0.016120251,-0.0113124335,0.011244047,-0.12166448,-0.085758284,-0.042860758,0.1479569,-0.018809702,-0.04115919,0.019816184,0.014299404,-0.014498414,-0.026719972,0.041147944,0.052434467,-0.023443915,0.050430283,0.07548585,-0.06758646,0.024487987,0.026895883,-0.08388213,0.030916404,0.006825818,-0.07299596,0.026820064,0.03418196,0.024631198,0.009842777,-0.092006445,0.042748574,-0.030297633,-4.868751e-33,0.15511389,-0.059659746,0.112649806,-0.03767969,-0.04013459,-0.010969733,0.059664425,-0.12249141,0.026595926,-0.0054630255,0.010750103,0.009375627,0.011485881,-0.04960752,0.008144953,-0.014960894,-0.060139306,0.072973855,-0.005014665,0.034547765,-0.048350945,0.107868396,0.0532608,0.032315303,0.039756313,-0.032157417,0.038645167,-0.0159668,0.027397277,0.030504087,0.019850284,0.064902164,-0.0762475,-0.03906141,-0.010190139,-0.006911519,0.025319818,-0.0033116622,-0.01376512,0.034031294,0.04485898,0.097757354,0.0535625,0.0078135,0.011032948,0.07386466,0.02363664,0.026801674,-0.0654707,-0.054600097,0.049038593,0.031246679,-0.08176361,0.021446133,0.094410956,0.06854379,0.036633242,-0.01881545,-0.0074372,-0.07048433,-0.086725324,-0.049354903,-0.0073653925,-0.075743034,0.07750428,0.07730274,0.079747826,0.015216696,-0.06881484,0.093771435,0.0070596645,0.022343194,0.017915072,-0.03895945,0.035639174,0.087902345,-0.08158862,-0.0033565746,-0.00068502803,-0.08377729,-0.027013985,0.039945427,-0.014430083,-0.055606857,0.07441196,-0.002127082,-0.019872693,0.064189844,0.04633718,0.009651831,-0.044817057,-0.033884645,-0.009839517,-0.018198341,0.021078568,-4.1343633e-08,-0.0004862951,0.069904424,-0.004270334,-0.07654349,-0.035841256,-0.009318317,0.016824331,0.043961525,0.049452726,0.030846871,-0.0069412175,-0.0032998798,0.017682044,-0.06392079,0.033424664,-0.0010797019,-0.012405901,0.028648252,-0.04057749,-0.09729891,-0.07565878,-0.019534824,-0.09899062,0.14145936,0.027702346,-0.04186162,0.05130721,0.002297602,0.0013048307,-0.06797891,0.03952835,-0.019534968,-0.06427809,-0.08823289,0.015609701,0.0024972965,-0.029178109,0.036967397,-0.022876345,0.00907248,-0.07451677,-0.03972915,-0.0011113249,0.004283334,-0.072478995,0.06443585,-0.0078015532,-0.035460338,-0.074652776,0.04127011,0.040257502,-0.08344944,-0.07258637,-0.09154821,-0.08429974,-0.03718311,0.008301019,-0.04046829,0.01276007,-0.10198149,0.021475984,0.03255009,0.072817914,-0.060120966 +2.7.9.5,"The enzyme phosphorylates granular starch that has previously been phosphorylated by EC 2.7.9.4, alpha-glucan, water dikinase; there is no activity with unphosphorylated glucans. It transfers the beta-phosphate of ATP to the phosphoglucan, whereas the gamma-phosphate is transferred to water [1]. In contrast to EC 2.7.9.4, which phosphorylates glucose groups in glucans on O-6, this enzyme phosphorylates glucose groups in phosphorylated starch on O-3 [2]. The protein phosphorylates itself with the beta-phosphate of ATP, which is then transferred to the glucan [1].",384,1.0,-0.08318402,-0.02749444,-0.012225045,-0.013519942,0.04389793,-0.0011148265,0.07242968,-0.016950991,0.06205651,0.00020620148,0.0059547876,0.07750928,-0.011337607,0.00021945313,-0.081064574,-0.024775032,-0.02922371,0.030286642,-0.023079235,-0.06133623,0.11489862,-0.018027205,-0.02214584,-0.0010526095,0.07588356,-0.046316206,0.058410134,-0.049552027,-0.09095088,-0.036069214,-0.074921615,-0.076979786,-0.0077435826,0.0553516,-0.03838218,0.13866617,-0.034503717,-0.07493273,-0.039781872,0.003817495,0.066931754,-0.035533044,0.0044156336,0.015716534,-0.041311704,0.005922672,-0.04747774,-0.0066092582,0.037967462,0.008441514,-0.024328934,-0.059356812,-0.052440636,0.07948684,0.005164969,0.06533429,-0.073918104,0.00705617,-0.016091894,0.058933478,-0.040377457,0.06370812,-0.011681411,0.019235788,0.044475906,-0.084334366,0.0018555918,-0.048512746,-0.0652883,-0.027899249,-0.08175121,0.059034422,0.042141195,0.002931905,0.026922774,-0.024891384,-0.040680215,0.047968455,0.032604575,-0.056974124,0.10685671,-0.019314714,0.03821408,0.049307305,-0.053946957,-0.020202704,0.000527196,0.028043948,0.015745537,-0.050982583,0.030789286,-0.05916388,-0.043341715,0.0019441474,-0.0032336176,0.014028843,0.052439604,-0.04367563,0.065266624,-0.032330282,-0.029801654,0.035775885,0.08625641,-0.034061793,0.019927371,0.056373883,-0.01709287,0.05577416,0.022406172,0.044216648,0.0410745,0.027320957,0.032206766,0.034020763,-0.051937047,0.070867665,-0.01923907,-0.065045185,-0.07466501,-0.031415198,-0.0088644875,-0.028184079,0.03866787,0.034281373,-0.085567534,0.11154148,-0.046416044,1.8151482e-33,0.038724016,-0.016212475,0.052320614,-0.03237265,-0.028761793,0.0034382723,-0.07439289,-0.05931035,0.03187808,-0.06423795,-0.06519761,0.018471606,0.0021189319,0.04471101,0.01642318,0.012003365,-0.0051633357,0.0019646403,0.07857871,0.008534868,0.03121379,0.072792076,-0.01826651,-0.020449419,0.07189569,0.033220988,-0.11808736,-0.04716164,0.036113344,0.0025657418,0.037386615,-0.018446269,-0.016554283,0.07520058,0.023916492,0.0020244864,-0.049827043,-0.039234646,0.076106034,-0.09309953,0.038840715,-0.026207281,-0.023355886,-0.08526513,-0.0011452069,-0.067254044,-0.013939738,0.026134541,0.01914247,0.057572097,0.061512645,-0.023332926,0.050488565,0.019314777,-0.053114265,0.008186227,0.0040078326,-0.035650447,0.017069157,0.07393981,0.047206316,0.09935602,0.028694429,-0.00081871846,0.021762004,0.036560077,-0.106870815,0.0069690263,-0.0364181,0.084740825,-0.08356989,0.011279884,0.047795564,0.027589245,-0.02678907,-0.037380412,0.020231774,0.026776765,-0.098772176,0.031903148,0.10721747,-0.030085092,-0.01662058,0.038077403,-0.06804624,0.06472769,0.036709685,-0.01835137,0.005995119,0.03630314,0.024990033,0.036309242,-0.053276032,0.018668478,-0.040527843,-4.0554368e-33,0.15201485,-0.10623707,0.06923048,0.008683391,0.039164316,0.0029550523,0.06910827,-0.084317155,0.04694594,-0.00062895066,-0.023033956,0.043079853,-0.05961997,-0.09997979,0.02023252,-0.015782753,-0.09287099,0.11858148,-0.04900601,0.0064231684,-0.005677092,0.08410563,0.02949053,0.02701466,0.05082455,-0.111457616,-0.005284088,0.04217015,-0.016058212,0.022097578,-0.0073420005,0.008358059,-0.015140934,-0.027810449,-0.021280399,-0.0357221,-0.002975169,-0.008567948,0.016452737,0.03275182,0.037847113,0.035092827,0.0407782,-0.046184905,0.07806866,0.15853046,0.0020447213,0.02765005,-0.09542698,-0.027530054,0.03288025,-0.033952586,-0.022770926,0.031799607,0.06919977,0.08773163,0.041302152,0.041542742,-0.038744878,-0.06263508,-0.052878924,-0.047560994,-0.006826363,-0.040207706,0.048147887,0.00059756637,0.00014387228,0.018010588,-0.022887466,0.050080962,0.012288118,-0.06553762,0.017471448,-0.0015369459,0.071565375,0.044868845,-0.08940369,-0.00034457675,-0.04573425,-0.07210284,-0.04285867,0.093473546,0.014777802,-0.077834226,0.037303794,0.054745235,0.010158817,0.052478977,-0.014390979,-0.004156727,-0.035123214,-0.055465303,-0.017227242,-0.037138227,0.055836435,-3.7972605e-08,0.039222997,0.015423557,0.0015224961,-0.04688618,-0.029021768,0.0017538973,0.10450257,0.11816495,0.028389897,0.0038975887,-0.050284836,0.047703486,0.0021508154,-0.04566629,-0.042880043,0.01511441,0.006685332,0.016476853,-0.021779431,0.004859172,-0.06159285,-0.025392102,-0.085529946,0.12946035,-0.026293242,-0.029720347,0.027616857,0.040491633,-0.079702005,-0.056370627,0.044520535,0.057441887,-0.022099093,-0.10866521,-0.04626411,-0.02849034,-0.042989805,0.031691547,0.040554646,0.08926329,-0.0056139487,-0.018606644,0.0104620475,-0.0066343816,-0.07363499,0.04213973,-0.026710527,-0.04725103,0.017781643,0.04122157,0.048606373,-0.0027935172,-0.116484925,-0.1105053,-0.052758094,-0.065944,-0.040561046,-0.07322489,0.047625516,-0.07638049,0.050604556,-0.005431327,0.12020285,-0.031187681 +2.8.1.1,A few other sulfur compounds can act as donors.,384,1.0,-0.07835385,-0.03627825,-0.0619109,-0.006008195,0.053011727,0.027582308,0.04487241,0.035587553,0.02342409,-0.036065776,0.06777142,0.0024315878,-0.05656737,0.05446181,0.0054803183,0.06280961,0.0033032808,0.03269912,-0.039965753,0.023510076,0.052084155,-0.047916796,0.0030611914,-0.025869621,-0.0023826275,0.11076522,-0.052629717,-0.027323298,0.044682037,-0.040162962,-0.0054101055,-0.007862816,-0.08074785,-0.033212125,-0.025604872,0.07328438,-0.054751623,0.0020527446,-0.052416645,-0.013317256,0.005957089,-0.07701929,0.01606261,0.00011688454,-0.066793315,-0.085268095,0.019645628,0.045407783,0.023711642,-0.08859271,0.06431061,0.026213918,-0.034508556,0.0993971,-0.027814629,-0.010080227,-0.06338946,-0.023045385,-0.0032747625,-0.06538691,-0.016537882,0.033731714,-0.004496628,-0.041527428,0.093442746,-0.0033206122,0.06628934,-0.030514985,0.016472112,-0.01926673,0.030233417,-0.030557975,0.025893506,0.03043115,0.035768382,0.114281826,0.015780067,-0.017566925,0.03617842,0.010027882,-0.010179573,0.05497646,0.047212664,0.050203767,0.041287422,0.013949099,-0.04603066,0.0056647,-0.03732743,0.04291966,-0.02036367,0.0013091399,0.06163661,-0.031432286,-0.10230579,0.04851924,-0.010214041,0.1408187,0.013667625,0.012526494,0.017064061,0.07195123,-0.08646478,-0.11915954,-0.04887725,-0.03650347,-0.039646853,0.034042213,0.03436375,0.029302508,-0.07456961,-0.02945916,0.028194832,-0.0076415846,-0.04509228,0.093841985,-0.013187816,-0.032754354,-0.15989336,-0.024681002,-0.005015351,0.048721004,-0.0045806863,0.010631815,0.014914855,-0.025602967,-0.15905198,-3.1981697e-33,0.07294119,0.07274769,0.11389755,0.016414601,-0.07747381,-0.013012539,-0.050645735,0.0044961665,0.0140503505,-0.019527702,-0.09026025,-0.01749659,0.040153153,-0.0413974,-0.061434798,-0.016439525,-0.051891863,-0.014130272,0.11090146,-0.023007186,-0.008060323,0.023330031,0.013632913,0.0038540752,0.05045512,-0.008002946,-0.013940039,0.014325692,-0.0023506926,-0.0074191308,0.066208206,-0.014896286,-0.014151337,0.012990706,-0.012047493,0.0071380693,-0.002779036,-0.017330984,-0.015857065,-0.024932569,0.05272244,0.022960339,0.056316704,0.050175812,0.03887969,-0.05424872,-0.058449354,-0.015246291,-0.017854871,0.02225841,-0.0064024725,-0.06367628,8.399297e-05,0.007681233,-0.025001649,-0.0039849193,0.024826497,-0.023377167,-0.009554336,0.0019460603,-0.009904539,0.049185507,-0.027456462,0.023224885,-0.08500885,0.036111284,-0.001676964,0.0124201765,-0.04654707,0.0367202,-0.057203725,-0.023720806,-0.027506003,0.022175306,-0.017237825,-0.0062276027,0.03328326,-0.031455055,0.119201526,0.03665039,-0.047426578,-0.12118538,0.015824873,0.04374007,-0.12200205,-0.034248028,-0.041529894,-0.08853943,0.04024259,-0.026663536,-0.0066708843,-0.1006222,-0.035480138,-0.11896349,0.010825905,6.125422e-34,0.031886626,-0.058557875,-0.005499397,-0.0375225,0.055892266,0.02954695,0.027186334,-0.10334135,0.06747561,0.049312394,0.036710504,0.018596493,0.08105732,-0.02403061,0.02984969,0.04819995,0.01640935,-0.00872023,0.013970502,-0.03646802,-0.033211693,0.14914691,0.021402357,0.0022926712,-0.02033861,0.022311786,0.008362799,-0.052959178,0.14110713,0.06096794,0.04885288,0.0023995757,-0.090806805,-0.092365645,-0.019192696,0.012926577,0.035254534,-0.018727712,-0.02403876,-0.075796776,-0.009457075,-0.071954496,0.09341809,0.13471882,-0.015059875,-0.0019174336,0.044148147,-0.0068872194,0.060651302,-0.025685487,0.049343854,-0.0064197066,-0.02807366,0.059519656,0.018321913,0.045388818,-0.010344615,-0.01745856,-0.012135682,-0.044892233,-0.028409123,-0.016079985,-0.015511345,-0.046785437,-0.04803541,-0.01924846,0.034729436,-0.036765628,0.045141906,-0.042286478,0.07258752,-0.048858695,-0.005197178,-0.010992101,-0.03899827,-0.06511337,-0.036668263,0.02645804,-0.001597386,-0.018910237,-0.049601633,0.02351535,0.033369757,-0.059003934,0.15945867,-0.08028752,0.03752011,0.0515191,-0.022023436,-0.006189524,-0.07692474,0.013680451,0.017191956,0.09874612,0.0021096794,-1.9334978e-08,9.45876e-05,0.0459662,0.033068147,0.03938577,-0.020320574,0.0014191855,0.012337423,0.031521916,0.0034740183,0.08702943,-0.020954316,0.11807054,0.027141377,-0.0020189944,0.038130384,-0.011115388,-0.032208007,-0.027339788,-0.06770073,-0.11994637,-0.05255596,-0.03818657,-0.025345637,0.028704155,0.011607774,-0.015539411,0.08038644,-0.05335201,-0.0017005696,0.0040819626,0.060272902,0.0020961033,-0.08704712,0.020017233,0.068496734,0.06334188,0.031267695,-0.036230974,0.0335528,0.00097278884,-0.0430259,0.008162842,-0.11102662,0.10407167,0.014208264,0.0412121,-0.05214023,0.058474164,-0.029222194,0.03555493,0.06555947,-0.042337995,-0.013527139,-0.06913466,-0.028338393,0.08565003,0.066939324,0.030277003,0.15455304,-0.027297122,0.06508301,-0.07943599,0.07285782,-0.00384523 +2.8.1.2,"The enzyme catalyses a transsulfuration reaction from 2-oxo-3-sulfanylpropanoate to an internal cysteine residue. In the presence of a dithiol such as reduced thioredoxin or dihydrolipoate, the sulfanyl sulfur is released as hydrogen sulfide. The enzyme participates in a sulfur relay process that leads to the 2-thiolation of some tRNAs and to protein urmylation by transferring sulfur between the NFS1 cysteine desulfurase (EC 2.8.1.7) and the MOCS3 sulfurtransferase (EC 2.8.1.11).",384,1.0,-0.054287955,-0.04072551,-0.04183236,0.006480286,0.013873443,-0.0376725,-0.044309635,0.06751124,0.04499853,-0.02041155,0.029509528,0.021837428,-0.036847223,0.024534032,-0.07313758,0.055145722,-0.06696113,0.05607657,-0.0041394276,-0.09873559,0.085286595,-0.013966216,-0.029997982,-0.008763335,0.030564437,0.009206958,0.013719901,0.019285802,-0.034384783,-0.02192099,-0.031450536,-0.08788491,-0.07236008,-0.03181236,-0.0027680127,0.12980719,-0.06222011,-0.036823083,-0.008167165,-0.05302622,0.04516629,-0.012220787,-0.036049105,-0.0127194105,-0.024650283,-0.004771874,-0.019244332,0.0745037,-0.01923509,-0.052112136,-0.07593266,-0.028269047,-0.015694588,0.10116283,-0.004824383,-0.014225374,-0.042651992,-0.004467228,-0.01146276,0.0025326798,-0.0020581372,0.038852207,0.0027892105,-0.05898012,0.07570639,-0.0874878,0.03286583,0.011138519,0.033194393,-0.01738853,-0.07821454,0.0036534995,-0.0090170745,0.021348314,-0.008440295,0.017331533,-0.04771364,-0.009241178,0.046166983,-0.04804227,0.1186734,-0.0027568273,0.043783557,0.084253676,0.03969931,-0.0719384,0.010510179,0.021061873,0.04030109,0.0441858,0.0006099565,0.0127368225,-0.015482145,0.0014606685,-0.09769615,0.01932507,-0.026297903,0.12409897,0.0016944523,0.003183854,0.03506983,0.04413171,-0.031591695,-0.110448636,-0.022655895,-0.008749485,0.005523132,0.1359986,-0.0010006598,0.033770703,-0.040904827,0.010281908,0.036988027,-0.0044768318,-0.07072185,0.15032725,0.0496772,-0.020602027,-0.072707914,-0.0101506915,5.106388e-05,0.051260374,0.0005922653,-0.0010788369,-0.07587078,0.02334425,-0.11012234,2.523765e-33,0.061306518,0.05876801,0.018309286,0.0104972785,-0.040349454,-0.042554006,-0.07113167,0.029668929,0.0024544068,-0.027168496,-0.07692009,-0.079591,-0.0012510582,-0.042409662,-0.0377666,-0.0982934,-0.005664748,0.057785355,0.062172767,-0.0068789353,0.027823256,0.053978413,-0.018123271,-0.05267768,0.04022795,0.031277236,0.00032666294,-0.003803551,0.014705331,9.5988464e-05,0.056865204,-0.09784118,-0.04359673,-0.042342365,0.10904715,-0.02542602,-0.02468236,-0.031292383,-0.026643585,-0.029800192,-0.03953984,-0.021857398,0.0319174,-0.062218923,0.0011968536,-0.03610799,-0.07876378,0.06137133,0.039964363,0.03126959,0.047175992,-0.051986095,0.083812766,-0.039619938,-0.014071663,-0.042482797,0.013130395,-0.06914372,0.055179596,0.01890216,-0.0073685143,0.042017214,-0.06363142,-0.035063423,-0.03184536,-0.042596877,-0.054308362,-0.036205783,-0.027446019,0.10040567,-0.09691929,-0.0294519,0.01990919,0.00044510857,-0.020501047,-0.043606628,-0.050481122,-0.06360972,0.023930654,0.0015470617,-0.048534643,-0.053892232,-0.023502134,0.0084091555,-0.04798809,0.0016800587,-0.041758027,-0.033472903,-0.021454811,0.043222226,-0.022906745,-0.024497349,-0.085913606,0.050748378,0.046971004,-4.4645224e-33,0.07557154,-0.030323565,0.037173264,-0.062167574,-0.038393416,0.046541367,0.031768143,0.034722537,0.03478601,0.019248428,0.044575274,-0.015734792,0.039222177,-0.053701214,0.013649873,0.0036449006,0.04484442,0.015563781,0.015871106,-0.0113711795,0.041648608,0.13630936,-0.03890016,0.08236895,-0.008714541,0.002854172,0.06059219,0.07157993,0.0579753,0.06676889,0.027151113,-0.089966,-0.013813793,-0.015284103,-0.0110334465,0.08272319,-0.025790114,0.006557852,0.03642147,0.035657793,0.01820213,-0.027831586,0.037379507,0.14169751,0.01533032,0.03117414,-0.08247312,0.025385015,0.031706113,-0.052833464,0.093898065,-0.029224802,0.02936495,0.05164722,0.03178958,0.023737226,-0.046952054,-0.023607139,-0.07378579,0.004366627,-0.02595181,-0.058972605,-0.018859692,-0.079417735,-0.039402228,0.0009689093,-0.09419607,-0.040831454,0.0374808,0.0056251106,-0.0031664178,0.0007939414,-0.034054223,-0.06692128,-0.016774377,-0.045773987,-0.076590866,0.038355917,0.013196868,0.0064575593,0.01115773,0.039920352,0.07181524,-0.07748901,0.07414885,-0.10926292,0.041082263,0.15096284,-0.032933295,0.0029898325,-0.012123137,0.010955222,-0.03874973,0.043070212,0.002558567,-4.159542e-08,-0.039659463,-0.075547755,0.05897162,0.0032272374,-0.025714085,0.07497736,0.02770908,0.042813007,0.008826692,0.051578432,0.009742728,0.10867495,-0.011608833,0.006112424,0.040522076,0.058654953,-0.010234904,0.07512439,-0.0076276213,-0.061126817,-0.01151,-0.03216911,-0.11640356,0.050225414,0.064597204,-0.012865442,0.01897327,-0.0329437,-0.09426046,0.028985929,0.10253792,0.021013534,0.01728149,-0.0074523203,-0.039094556,0.089007616,-0.063241675,-0.015649443,-0.01094527,-0.04046124,0.0005364045,0.09557902,-0.07868663,0.053983063,0.00634899,0.016843144,-0.006906838,0.09200603,-0.093735896,0.07077339,0.09948366,-0.060506918,-0.01236156,-0.08091406,-0.041784782,-0.0075990316,0.036507454,-0.07680822,-0.012537155,-0.013663913,0.11863785,-0.008456099,0.15739484,0.010218371 +2.8.1.3,"The primary product is glutathione hydrodisulfide, which reacts with glutathione to give glutathione disulfide and sulfide. L-Cysteine can also act as acceptor.",384,1.0,-0.04468161,-0.0531682,-0.022569727,-0.026095625,0.114683636,0.07574377,-0.01857047,0.08129405,0.033764854,-0.051514376,0.067647316,-0.008108313,-0.014523106,0.036548544,-0.07097416,0.08058317,0.025723163,0.06901587,-0.052972615,-0.056471717,0.0058066766,-0.014293333,-0.03867847,0.025216365,-0.011772323,0.05845385,0.06228437,-0.009314485,-0.03480497,-0.05915314,-0.06204787,-0.0849629,0.009296539,0.017729342,-0.03944345,0.06739198,-0.09657878,-0.049757916,-0.015640244,-0.05950224,0.026627278,-0.044381898,0.009482304,-0.043823987,0.022719126,-0.017391054,-0.0009478942,0.065946504,0.017756538,0.0027418113,-0.008908081,0.029630193,-0.010111889,0.14370354,-0.0008880142,-0.004254232,-0.11130062,-0.0069541354,0.007752306,0.0021798986,-0.0038046516,-0.0054897363,-0.07812474,-0.08189771,-0.009144298,-0.034673586,-9.3521056e-05,-0.017779991,-0.0731934,-0.018925706,-0.019369759,-0.027616853,0.004336368,-0.0022760117,0.029506413,0.070814416,-0.05611968,-0.06087343,0.06397165,0.0292196,0.026670367,0.0050675576,0.0019539339,0.12610628,0.06409863,-0.021375457,-0.081248425,0.09278547,0.0046009826,0.0048186807,-0.010865755,0.01019959,-0.029970469,-0.017422518,-0.112574056,0.033551455,-0.0026818318,0.022554666,0.009076341,-0.016703159,-0.026944889,-0.0015659867,-0.07266922,-0.1462526,-0.12456174,-0.039658748,0.0077533433,0.021425411,0.023491489,-0.05084588,-0.05648606,-0.058782574,-0.012363626,0.009146745,-0.0670437,0.0866474,0.124988995,-0.06516164,-0.08395001,-0.054248262,0.029677741,0.028907232,0.052426625,0.027368905,-0.018618815,0.038620595,-0.037106488,5.245458e-33,0.052906185,0.04993631,0.03286285,0.04786588,-0.0449084,0.028892538,-0.041112922,0.0106463125,0.01910489,-0.0871516,-0.08994347,-0.03165445,-0.008519906,0.024292333,-0.068222694,-0.0027105743,0.02072459,-0.010842742,0.11518781,-0.06970598,0.016657513,0.094550565,-0.043842908,0.010545897,0.011292784,0.0068880455,0.04119249,-0.00095458806,-0.0021184029,0.0025151554,0.025359621,-0.023814786,-0.0062174657,-0.02131012,0.020772312,0.0075847046,-0.086276844,-0.024707807,0.05663903,-0.025528155,-0.035523597,0.019337108,0.0024061203,0.012285306,0.040890057,-0.01818175,-0.051096827,0.006043175,0.012728593,0.045685753,0.078283854,-0.035999525,0.023028674,-0.021093331,-0.05352149,0.009269201,-0.01163857,-0.021398278,0.01131729,0.076589,-0.048137195,0.121857636,-0.0682768,0.011214469,-0.033895966,-0.0009211933,-0.006086418,-0.035617,-0.09605144,0.08375119,-0.0148267,-0.05273795,0.06140051,0.08497385,-0.016857872,-0.031667557,-0.031770896,0.016898526,0.029466894,-0.007905286,-0.08791366,-0.0014714741,-0.0206942,0.06600273,-0.121102735,-0.042722456,0.0012878985,-0.05691934,0.038898353,0.04522115,-0.025715318,-0.046131704,0.0079915775,0.082223095,0.032464296,-6.1816045e-33,0.060637984,-0.082207076,0.101276614,-0.06336733,0.020796612,0.054430004,0.017079422,-0.09577762,0.16403067,0.033980593,0.06034938,-0.018329808,0.010825044,0.037411842,0.0050899144,0.03916071,0.005560091,0.074032895,-0.011850797,-0.04013433,0.030577444,0.083075516,0.040212568,0.026761994,0.08400956,0.008824092,0.039926533,0.051325306,0.087362826,0.09137499,-0.013553492,-0.022366518,0.006298343,-0.06973252,0.03686146,0.0855538,-0.031646956,-0.048793193,-0.0037119628,-0.001350461,-0.011531067,-0.031845294,0.034845848,0.12367795,0.02623859,-0.0055229473,-0.012910156,0.0018529891,-0.015443235,-0.060178746,-0.009243774,0.0120723685,-0.01817418,0.0035846196,0.07860878,0.07135168,0.0055422885,-0.053933322,-0.032473657,-0.040787723,-0.031313706,-0.0804278,-0.051583126,-0.08308328,-0.005695481,0.0030399081,0.018886503,-0.033878554,0.03925545,0.031243017,0.07235826,-0.013580983,0.07395543,0.054433104,0.0014127978,-0.048256706,-0.097273245,0.03121889,0.0149722425,0.017676957,0.005379583,0.027785929,0.017440425,-0.04947886,0.030248174,-0.05176322,0.017834904,0.064549446,-0.0351037,0.025337094,-0.041680202,0.035262667,-0.015629264,0.068444766,0.022439947,-3.5084668e-08,-0.018397916,-0.08711082,0.051849175,-0.08427027,-0.07978784,-0.0021065057,0.035544913,0.056354865,-0.020562492,0.01235403,0.013161728,0.1188992,0.020316182,-0.04498479,0.03413545,-0.020352451,0.013351458,0.006041185,-0.012169827,0.0115944315,-0.032235254,-0.0059449016,-0.014808743,-0.08410578,-0.061524224,-0.04549945,0.017756945,-0.06584289,-0.050437488,0.032589026,0.110613525,-0.060326133,-0.015604326,-0.06143372,-0.0016595343,0.089649186,-0.047221743,-0.010256573,0.023689784,-0.030840976,-0.021805005,0.055979677,-0.08450748,0.055832196,-0.013114103,-0.002547858,-0.0041934587,-0.027125563,-0.047088012,0.056288306,0.04311177,-0.08451225,0.006190747,-0.07348092,-0.05472075,0.00645076,0.04198827,-0.04171522,0.029186236,-0.0920353,-0.0019342765,0.02970742,0.13738237,0.1251334 +2.8.1.4,"The enzyme, found in bacteria and archaea, is activated by EC 2.8.1.7, cysteine desulfurase, which transfers a sulfur atom to an internal L-cysteine residue, forming a cysteine persulfide. The activated enzyme then transfers the sulfur to a uridine in a tRNA chain in a reaction that requires ATP. The enzyme from the bacterium Escherichia coli forms 4-thiouridine only at position 8 of tRNA. The enzyme also participates in the biosynthesis of the thiazole moiety of thiamine, but different domains are involved in the two processes.",384,1.0,-0.037988152,-0.019786142,-0.08164715,-0.05896144,0.02123408,-0.019054238,-0.07174368,0.071078636,0.049302258,0.0043804715,0.052038025,-0.031849746,-0.043036927,0.036349874,-0.030554079,0.034046464,-0.03811663,0.028384348,-0.0063701035,-0.09411848,0.08736337,0.058755565,-0.07134177,0.002526245,-0.025242021,0.05704386,0.085696995,-0.02330283,-0.057611145,-0.05420785,-0.10689322,-0.09230346,0.050483417,-0.020465523,-0.00015171662,0.13005227,-0.08732975,-0.022271216,0.032857876,-0.02141896,0.041367214,-0.022694318,-0.030339044,-0.017557833,-0.058592852,-0.028432976,0.08242453,0.08535297,0.027889807,-0.029094096,-0.04989844,-0.0048518428,0.008599578,0.04815936,-0.033348437,0.022418596,-0.037460655,-0.0022613767,-0.013580318,-0.01540355,0.059487917,-0.014200364,0.033108465,-0.022389859,0.054141324,-0.06394434,0.027115753,-0.043308377,0.022253355,-0.07545382,-0.04144361,0.006128476,0.024889758,0.050786067,0.00043083957,0.010512859,-0.019469103,-0.041574378,0.04660432,0.0002966386,0.047809985,-0.06325709,0.04094067,0.07434205,0.06098707,-0.032451887,0.020850662,0.019620402,0.047683973,0.013686999,0.093486324,0.014202112,-0.0107172625,-0.050731596,-0.08220452,0.024727317,-0.0046452302,0.06828074,0.0120969,-0.03089599,0.04037197,0.027163986,-0.10532725,-0.037436586,0.003276457,-0.036808476,0.060596764,0.10611386,-0.038842462,0.0014499987,-0.011462393,-0.02300356,0.06205605,0.027425194,-0.028230025,0.106068544,0.07841554,-0.041987155,-0.06575909,-0.02129181,-0.019157993,0.0028354945,0.07098126,0.037477154,-0.049941905,0.026970666,-0.15868412,8.5983555e-34,0.07238185,0.08401632,0.016938994,-0.04286658,0.0027922783,-0.04034222,-0.054848593,0.054274734,-0.010231306,-0.040155824,-0.06667619,-0.06714828,0.05329981,-0.04597666,-0.048923187,-0.06229029,-0.017801274,0.031609163,0.10560718,-0.004129244,0.044349015,0.07708522,-0.011482867,0.0006923065,-0.0030611518,0.07339855,0.03654147,0.030592293,0.010777752,0.012601344,-0.0083414195,-0.10188148,-0.0915066,-0.06080341,0.13213453,-0.024419133,-0.059384514,0.05023674,-0.060661674,0.0015530861,-0.03472393,0.022335492,0.008863058,-0.048059758,0.004534874,-0.0958792,-0.08352956,0.08862116,0.027452499,0.034122527,0.04117298,-0.0759469,0.08969058,-0.06633217,-0.03764356,-0.031423036,0.009124766,-0.022477346,0.034005564,0.011200762,0.06328153,0.050897785,-0.089729965,0.063387945,-0.0014735047,0.028468998,-0.06834901,-0.05098786,0.0062830686,0.117044725,-0.043357536,-0.014838523,0.056570422,0.020896591,-0.012489292,-0.010939188,-0.121377826,-0.022163723,0.03737102,0.01461544,-0.012721997,-0.058177844,-0.017858332,0.01837635,-0.030239249,-0.033326406,-0.011120231,-0.0071476456,-0.0105851125,0.023723353,0.0402334,-0.05878017,-0.06522957,0.036417652,0.06959589,-2.5316282e-33,0.09450809,-0.05204749,0.07421744,-0.066075124,-0.01619045,0.059226364,-0.01406593,-0.0061528,0.03336992,-0.014450825,0.07340498,0.00028775993,-0.0011088484,-0.013777314,0.007141684,-0.000561351,0.016135095,-0.0036158836,-0.059849914,-0.067169026,-0.0056726555,0.030102152,0.012886475,0.05016,0.015771918,-0.02566142,0.051179145,0.07792227,0.026443968,0.04542327,-0.041630805,-0.00945126,-0.021082342,0.0023394239,-0.06768495,0.053281374,-0.039791457,0.010233179,0.06864219,0.006779926,0.029724998,-0.03604681,0.0073179835,0.13460296,-0.01269262,0.0795132,-0.013331411,0.02624578,-0.026707774,-0.0783734,0.063973725,-0.041395623,0.035042763,0.0028984118,0.059275515,0.06240026,-0.040944267,0.012488739,6.415367e-05,0.010450304,-0.02539591,-0.09958819,-0.012234691,-0.043541115,-0.021022208,-0.015442308,-0.12231432,0.05011183,0.0114939455,-0.011054437,0.055367656,-0.005891594,-0.012574382,-0.0076940795,-0.03836211,-0.042135756,-0.032874182,0.009940646,0.024022156,-0.009253594,-0.03866109,-0.018636404,0.014817451,-0.07675912,0.010144406,-0.05581049,0.07363759,0.095562324,-0.059158806,0.032494213,-0.05055177,0.032860577,-0.012371891,0.039261337,0.0071214344,-3.8801804e-08,-0.02292445,-0.07823445,0.036136165,-0.02060354,-0.03257244,0.07472762,0.006042703,0.083449066,0.058134813,-0.023121515,-0.02008121,0.11566698,0.008898098,0.011482383,0.049348753,0.0476974,-0.019483414,0.023894517,0.0030936843,-0.04394081,-0.016183516,-0.046945598,-0.10619187,0.00598639,0.051125355,-0.029308625,0.0032905766,-0.033009402,-0.07400702,-0.021874573,0.05021074,-0.020738812,0.019951286,-0.015686503,-0.051191516,0.051114935,-0.055415586,-0.059323102,-0.03070759,-0.031491864,0.039937075,0.058685116,-0.15742062,0.044251278,0.014592819,0.022977248,0.0067248982,0.10137582,-0.06317382,-0.015395002,-0.011206131,-0.026780013,0.047384392,-0.050699644,-0.02346307,0.024248296,0.044013783,-0.10539658,-0.039665572,0.02948015,0.1412312,0.023113329,0.14917679,-0.033502698 +2.8.1.5,"The enzyme from Chlorella shows very little activity towards monothiols such as glutathione and cysteine (cf. EC 2.8.1.3 thiosulfate---thiolsulfurtransferase). The enzyme probably transfers the sulfur atom onto one thiol group to form -S-S-, and sulfide is spontaneously expelled from this by reaction with the other thiol group. May be identical with EC 2.8.1.1 thiosulfate sulfurtransferase.",384,0.99999994,-0.024229672,0.0069048502,-0.0415833,0.008432451,0.03813019,0.07073891,-0.113615274,0.0787162,0.015022572,-0.043385163,-0.0036006279,-0.067335546,0.031405617,-0.009260181,-0.041853,0.051603295,-0.0758932,-0.056448072,-0.04353581,-0.07909895,0.055039827,-0.012242991,-0.106960736,0.009477144,0.024471285,0.057627074,-0.027684508,-0.041749824,-0.015082822,-0.09982448,-0.08160264,-0.04292033,0.027853003,-0.02935218,0.047947153,0.09664033,-0.053538878,-0.020536134,-0.009534629,-0.0729187,0.015047882,0.013774303,-0.06665307,-0.0031445932,-0.073220305,-0.03112642,0.062951565,0.013622709,-0.022130368,-0.047241855,-0.029385109,-0.08121301,0.05263848,0.07028213,0.010957876,-0.0065820278,-0.027246507,-0.008582228,0.04004587,-0.00017375452,0.021066269,-0.02651334,0.005627157,-0.03141845,0.030789813,-0.048392255,0.015879622,-0.055471875,0.006375148,-0.07073786,-0.073139645,-0.022368794,-0.024316348,0.058511637,0.019807452,0.019921288,-0.019127062,-0.05446645,0.013435628,-0.016953109,0.016526308,-0.049200933,0.0039234045,0.061080314,0.03616691,-0.046714313,-0.010466862,0.015398531,0.02366279,0.022712642,-0.0002571457,0.00028798374,-0.00036144326,-0.02005254,-0.09878773,0.09167383,-0.026286509,0.100625224,0.05788008,-0.021601398,0.033642612,0.020756984,-0.09148471,-0.07415265,-0.027341887,0.0029653858,0.034677006,0.069476575,0.00014182564,-0.038536724,0.002716594,0.00040712545,0.009667088,0.027034286,-0.06489335,0.13100483,0.10954292,-0.03305939,-0.11224493,0.03909447,0.01308195,-0.015691167,0.02448463,0.015487936,0.0066319336,0.051198475,-0.14238355,3.878696e-33,0.111541815,0.092190765,0.022419889,-0.057351794,0.006733387,-0.08297048,-0.08558188,0.078549616,-0.00043207768,-0.070661575,-0.055516265,-0.04123172,-0.036679614,-0.042253308,-0.01437476,-0.013840185,0.013732715,-0.020354068,0.021320995,-0.039198305,-0.0027874794,-0.0098044295,-0.06993533,0.007667882,-0.0057135914,0.062164806,0.0924555,0.05570035,0.06750777,-0.0019800884,0.012360512,-0.0770424,-0.049042486,0.030047689,0.088416114,0.008884729,-0.00014814115,0.025694061,-0.03500162,-0.01742131,0.0077953152,0.037520003,-0.0041684825,-0.06119469,0.03738725,-0.08230458,-0.11915507,0.037925087,0.088893674,0.057438966,-0.004911627,-0.04492182,0.09363242,-0.0032009329,0.013503852,0.053737756,0.052382044,-0.02582234,0.024141654,0.051839564,0.02142827,0.072927974,-0.062055506,-0.0019507319,-0.038582247,0.057689432,-0.060002044,0.013406208,-0.04972339,0.028928503,-0.07466422,-0.004728541,0.02462058,0.029531619,0.022702733,-0.021676302,-0.018227594,-0.03401463,0.029924523,0.014486985,0.019115523,-0.013646624,0.045679912,-0.033118337,-0.104828656,-0.06665752,-0.015433109,-0.038573895,0.0093108835,0.065738484,0.016837426,-0.04088077,-0.046863567,0.07290722,-0.04635899,-5.557461e-33,0.025629193,-0.016423387,0.08598871,-0.09149027,-0.0041980986,0.0649652,-0.056044,0.02540465,0.042201646,0.012409633,0.08665129,0.05774501,-0.0089080585,-0.019869754,0.0137183815,0.024011953,0.0965536,0.0657362,-0.04404298,-0.028026756,-0.05405128,0.104846075,-0.020537628,0.03381255,0.013572632,-0.0030036394,0.044650186,0.10049232,0.07161941,0.07105607,0.008298693,-0.021350743,-0.023518175,-0.016816039,-0.014647569,0.008661521,-0.051659416,0.014100455,0.07651136,0.04183965,-0.0102043245,-0.051110964,0.043740332,0.055378843,0.048773535,0.075961165,-0.06704844,-0.010731069,-0.0011056218,-0.05128475,0.07482208,0.03340046,-0.02270355,0.0659803,0.04299163,0.032417305,-0.015531852,0.016684614,-0.00075105997,-0.068351105,-0.013803,-0.08759786,-0.105257906,-0.053615253,-0.042022966,0.03677111,-0.08378504,-0.03963972,0.025106963,0.080928,0.034215525,0.011987296,-0.032544963,-0.024301983,-0.03124511,0.007237949,-0.089024976,-0.0062975413,-0.026651775,-0.026490267,0.034803856,0.063543856,0.061327677,-0.11888452,0.027261553,-0.075851634,-0.04377011,0.11627228,0.00016854217,0.022549916,-0.08673143,0.016672257,-0.04922737,0.046099406,0.017665323,-4.6310717e-08,0.013903827,-0.067406945,0.016432803,0.003069942,0.010397042,0.0063881604,-0.008727033,0.01866048,0.0732192,0.016146233,-0.098511845,0.09270008,0.0347087,-0.032355603,0.013526988,0.007790506,0.082482636,0.011604815,0.021824896,0.016976357,-0.060378995,-0.03587762,-0.040239643,0.024879973,-0.007825555,-0.041928373,0.023821035,-0.03408382,-0.07409581,-0.03830333,0.0688254,0.08337146,-0.027456947,0.0036983008,-0.056080937,0.05289449,-0.03120068,-0.003882272,-0.031714518,0.02434601,0.08046876,0.04188995,-0.12452393,0.0758469,-0.007460387,-0.010159053,0.0033300219,0.03308034,-0.029406417,-0.044158347,0.07903699,-0.040053263,-0.044165846,-0.06682273,-0.051949758,-4.3358326e-05,0.07363064,-0.05971311,-0.057155367,-0.024234606,0.10740702,-0.027581556,0.15807205,0.009083796 +2.8.1.6,"The enzyme binds a [4Fe-4S] and a [2Fe-2S] cluster. In every reaction cycle, the enzyme consumes two molecules of AdoMet. The first reaction produces 5'-deoxyadenosine and 4,5-secobiotin. Reaction with another equivalent of AdoMet results in abstraction of the C-6 methylene pro-S hydrogen atom from 4,5-secobiotin, and the resulting carbon radical is quenched via formation of an intramolecular C-S bond, thus closing the biotin tetrahydrothiophene ring. The sulfur donor is believed to be the [2Fe-2S] cluster, which is sacrificed in the process, so that in vitro the reaction is a single turnover. In vivo, the [2Fe-2S] cluster can be reassembled by the Isc or Suf iron-sulfur cluster assembly systems, to allow further catalysis.",384,0.99999994,-0.06520234,-0.035823226,-0.10398266,0.059066795,0.093058296,0.029016197,-0.055488106,0.07054046,0.030276584,-0.0081483275,0.00830415,-0.04995008,-0.092427045,-0.0135070225,-0.030268498,0.051507603,-0.08206066,0.020253228,-0.0131034395,-0.06357676,0.009146988,-0.070146784,0.0137866475,-0.08786348,-0.025608862,0.09671825,0.03819448,-0.022448497,-0.03151701,-0.05305615,0.019581473,-0.020736529,-0.061441343,-0.019356394,-0.04950244,0.12334156,0.009255357,-0.06612121,-0.00057047216,-0.011927339,0.010362037,-0.00329043,-0.06713003,-0.0016223141,-0.0073609026,-0.104072735,-0.03138909,0.017733539,0.06107346,-0.08868838,-0.03620259,-0.025723627,-0.049064413,0.09016136,-0.009106192,0.06303709,0.033061974,-0.027350396,-0.006321579,-0.03791955,0.11232338,-0.04402917,-0.0013479147,0.008180154,0.03644357,-0.019015074,0.052574888,-0.05600567,0.03763978,-0.027580041,-0.05699498,0.018936792,0.011721063,0.04864062,-0.006089208,0.07364123,-0.0098899845,-0.032085124,0.053174455,-0.01936966,0.0010806657,-0.04403768,0.052791834,0.049342,0.026543394,0.011804705,-0.002885737,-0.0015589288,0.0043020053,0.041426763,-0.004579031,0.02677516,-0.0042006816,-0.037000477,-0.072900616,0.020771934,-0.020297557,0.070239365,0.050922204,-0.0156097375,-0.04306268,0.05320743,-0.09215346,-0.09099665,0.0061617726,-0.030845096,-0.031592455,0.09479451,0.09052438,0.052953,-0.01005892,0.028391166,0.048333395,0.023487369,-0.023240542,0.16734886,0.014463009,-0.0028425776,0.017914293,0.022709005,0.054262083,0.07022308,-0.012211008,0.041470762,-0.016373675,0.010556602,-0.18018503,1.4425372e-33,0.09906456,0.061858933,0.09224859,0.0697895,-0.017753175,0.014250457,-0.10537837,-0.004676991,-0.0119829625,-0.013721151,-0.101254836,-0.09469091,0.12126537,-0.039008092,-0.0021652223,-0.114969626,-0.04520972,-0.006055645,0.08839304,-0.038637515,-0.013485671,0.0622756,-0.06610996,0.021690868,0.02783051,0.060004216,0.0076541556,0.07253174,0.03536347,0.019954897,-0.09366729,-0.040283237,-0.079249896,-0.030423295,0.09583025,-0.05060732,0.038585808,-0.035855766,0.009324297,-0.02724293,0.052119948,-0.014478463,0.028138869,-0.037337698,0.1100074,-0.08427839,-0.042816322,0.021401074,0.05239112,0.0686387,0.0021779793,-0.11013637,0.10371845,0.02200026,-0.0992629,-0.0045114597,-0.004983142,-0.042377286,0.046044867,0.07713566,0.033064943,0.019639771,-0.015085999,0.03159247,-0.004401718,0.09519448,-0.01909467,0.008421422,-0.061837953,0.09303116,-0.06040482,0.060946763,0.051048845,0.017892968,-0.010281055,0.017877094,0.0035136791,0.021414023,0.028226122,0.009601142,-0.044937413,-0.024967982,-0.038775075,-0.0026775706,-0.0052724993,-0.038318943,-0.0817489,-0.057712257,-0.017304594,0.0013448922,0.06290501,-0.041218903,-0.07468848,-0.028822698,-0.05790299,-3.75499e-33,0.04701194,-0.033309076,0.0140837105,-0.060688574,-0.04920593,0.038605165,0.025594233,-0.017347759,0.007664355,0.008998233,0.10498138,-0.012959576,0.085057296,-0.09539758,-0.023816377,0.007584548,-0.038189854,-0.019069713,0.060768884,-0.0025153456,0.06824565,0.04617271,0.03476644,0.027580323,0.055405665,-0.0029791095,0.02454252,-0.0030424956,0.07830924,0.058339763,0.054526772,-0.09734214,-0.04909821,-0.03492689,0.0022495287,0.012974351,-0.04727253,0.0011902823,0.08103448,-0.0012282715,-0.029473918,-0.029575968,-0.008881256,0.1395441,0.023754189,0.017707033,-0.023931349,-0.0141921975,-0.0111839585,-0.029718641,0.014758045,-0.046346266,-0.053133126,0.003892566,-0.047318954,0.035770833,0.03819022,0.008107647,-0.038546607,0.031417903,0.027756624,-0.07694204,0.08293824,-0.0014427744,-0.0107683325,0.023520019,-0.013321882,0.05952686,-0.013577289,-0.023890397,0.034500398,0.0028031426,-0.03465021,0.0036901443,-0.058764227,-0.057996217,-0.01205584,-0.0017776544,0.0029031984,0.011299818,-0.0643713,0.049190965,0.011024817,-0.09546509,0.034482006,-0.06787992,0.05101331,0.11060684,-0.003100011,0.03380227,-0.07788025,0.01317249,0.012946762,0.037421197,0.0024361806,-4.7070305e-08,0.006679173,-0.0392263,0.074441716,-0.019557254,0.007778061,0.010764657,-0.040522803,-0.02596567,0.010055572,0.007721499,-0.03935919,0.09450827,-0.061586116,0.033974737,0.015165424,0.016831366,-0.0709315,-0.00046354072,-0.0014435702,-0.045982696,-0.05485497,-0.067729004,-0.08620238,0.030002238,0.05289227,-0.043215096,0.0042054146,0.004750925,0.025968045,-0.094268486,0.004659289,-0.008620476,-0.06141092,0.054079972,-0.09006124,0.017919833,-0.097603396,-0.0339634,-0.009600893,0.032999355,-0.013840942,0.0018172537,-0.07572448,0.0886864,-0.010829428,0.046547566,-0.0037760648,0.06032724,-0.025526011,0.035858233,0.031511836,-0.024056377,-0.04376989,-0.051224552,-0.078318596,0.07964605,-0.040541507,0.02624572,0.06686832,-0.0023960187,-0.016240997,-0.031377494,0.07596723,-0.015297816 +3.1.1.85,"Involved in biotin biosynthesis in Gram-negative bacteria. The enzyme exhibits carboxylesterase activity, particularly toward substrates with short acyl chains [1,2]. Even though the enzyme can interact with coenzyme A thioesters [3], the in vivo role of the enzyme is to hydrolyse the methyl ester of pimeloyl-[acyl carrier protein], terminating the part of the biotin biosynthesis pathway that is catalysed by the fatty acid elongation enzymes [4].",384,0.99999994,-0.102296,-0.021065483,-0.048141256,0.015378624,0.0066672578,0.088735685,-0.11634367,0.06404442,0.006997491,-0.06472747,0.025556661,-0.05827785,-0.05405026,0.001232004,-0.048555247,-0.0043308507,-0.05545979,0.04736356,0.010719413,-0.06713599,0.08562754,-0.0036406447,-0.032125775,-0.028274937,-0.01962778,-0.06964837,0.019689769,-0.025178744,0.014982783,-0.057213638,-0.01026347,-0.015033769,0.021572001,-0.020473322,0.04953466,0.09643436,0.008234471,-0.10777568,0.13668889,-0.008104883,0.06432739,0.02227826,-0.07640446,-0.04883808,0.010038049,-0.07635859,-0.010587652,-0.031378385,0.012348878,-0.05975052,-0.0800502,0.021358758,0.027067441,-0.046316408,0.016726933,-0.013559688,0.070928596,-0.04986848,-0.058564458,-0.011558337,0.07794592,-0.04962419,-0.04161914,-0.039880916,-0.09030764,-0.087973095,-0.017033603,0.0023984998,0.056642666,0.013142703,-0.08931039,-0.07035398,-0.01317785,0.0037400324,-0.027542474,0.052767176,-0.062347,-0.036610514,-0.02537472,0.0054339836,0.028712388,-0.0822199,0.008420639,0.058888808,0.027297713,-0.08586358,0.048255276,0.041801836,0.01227501,0.1378262,0.024162237,0.009150421,0.03113262,-0.022125293,-0.09256568,-0.036606833,-0.013898467,-0.063895516,-0.02712017,-0.06080966,0.038456008,0.037473325,0.007882912,-0.039567847,-0.053000525,-0.008931858,-0.01803106,0.074161015,0.08096308,-0.02057107,-0.023485651,0.041034617,0.053918634,-0.009900743,-0.118557915,0.08531585,-0.037521508,-0.07703566,-0.015163959,0.022569137,0.0028008292,3.2732634e-05,0.010488604,0.089420095,0.02672449,-0.035277527,-0.14866695,3.105577e-33,0.07391305,0.003046244,-0.013159825,-0.02699942,0.0095722675,-0.01944428,-0.1592256,-0.011908769,0.010130607,-0.05896651,0.008938759,-0.06632082,0.024333635,0.02576015,0.006112133,-0.052585255,-0.03340998,-0.02359987,0.047598798,0.06669616,-0.041726273,-0.0035342274,-0.063895665,-0.015568223,0.04461113,-0.0043293443,0.003578085,0.024011483,0.007412627,0.0073318426,0.010651992,-0.08793266,-0.03330546,0.03387577,0.13659532,0.006850718,0.016407447,-0.030534888,-0.034783106,0.11930797,0.054012932,0.0142199285,0.032905824,-0.042258218,0.029963166,0.0034622932,0.013286269,0.12124835,0.06513529,0.09806058,0.060629483,-0.050109312,0.06032366,-0.004344144,-0.03361907,0.060449824,-0.113738075,-0.01833867,0.017065696,-0.0023451678,0.07603266,-0.037949048,-0.03406493,0.0027396746,-0.0204963,0.023438131,-0.07390114,0.014827131,-0.030376054,0.115811825,-0.030772088,0.022112852,0.0936984,0.053561494,0.05888427,0.02214005,-0.07212931,0.0032231186,0.0055634496,0.015004218,0.019285075,0.02780077,0.024618424,-0.061412483,-0.038292672,0.009775568,-0.0066613536,0.022339953,0.062410723,0.007115638,0.033113167,-0.09149245,-0.03958873,0.1101138,-0.050215743,-5.114241e-33,0.068811424,-0.08872403,0.059851505,-0.106601045,-0.030365296,0.03918609,0.01928366,0.039012693,-0.014672313,-0.026763037,0.053288277,0.029981706,0.050577708,0.015213648,0.0034623106,0.035402436,-0.014097836,-0.0029244581,0.0015136049,-0.022487376,-0.05008377,-0.014208785,0.032166213,0.0641498,0.021435477,0.070845395,-0.04128529,0.085945636,-0.01620471,0.0022957332,0.047937825,0.017880525,-0.027489362,-0.04442836,-0.008040927,0.061980464,-0.061124876,0.02913868,0.04249943,0.034627903,0.0033314435,-0.036274586,-0.0020916357,0.0095292,0.047328953,-0.039072905,-0.0511947,-0.07296833,0.040317643,-0.04838231,0.0020520505,0.04234026,0.04531531,-0.01941422,-0.0123253595,0.03655909,0.031379152,0.02388148,0.09025247,-0.0002995331,0.0017497004,-0.048170134,0.049412068,0.0033393828,-0.02485991,0.06372408,0.00032787432,0.061164852,0.0501161,-0.028425014,0.066202976,0.10769894,0.025780039,0.07242082,-0.00630659,-0.021517163,-0.058336075,-0.09415528,-0.05170214,-0.031000601,-0.03375601,0.013249165,-0.048467062,-0.13022433,-0.10448429,-0.002958273,-0.020271512,0.044243995,-0.025094349,0.015490222,-0.011431464,0.010357308,0.008370235,0.053447198,9.365414e-05,-4.353009e-08,0.004957654,-0.059634898,0.038079258,-0.025497338,-0.037425265,0.058933403,0.015766313,-0.03298743,0.02500407,-0.03269063,-0.042956755,0.027241914,-0.052243248,0.061953567,0.00012094179,0.045660086,-0.07097159,-0.028988782,0.030748019,0.0025290227,-0.092873596,0.03700976,-0.08801314,0.06871683,0.0069491197,-0.020457415,0.0032512832,0.052108865,0.02654007,-0.03497419,-0.0037305625,0.088575125,0.0054704756,0.015334846,-0.0704897,-0.007220866,-0.0481861,-0.037426256,-0.050168607,0.055238668,0.09014334,-0.01087396,-0.058721848,0.004796739,0.08456345,-0.032577578,0.05121066,0.056659967,0.022740304,0.013894401,0.07115747,0.015310058,-0.03730158,0.016692823,-0.018593889,-0.04534467,-0.018032258,-0.056419574,-0.03626681,0.019893147,-0.030607264,-0.04399405,0.17826591,-0.048841923 +2.8.1.7,"A pyridoxal-phosphate protein. The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors. The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) [2]. In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation [1].",384,1.0,-0.0645758,-0.057063207,-0.10780688,0.022622608,0.039773855,0.05074052,-0.008834079,0.012884117,0.0326289,-0.036077797,0.023777205,0.0005699986,-0.0021763276,-0.006828639,-0.06836842,0.02786884,-0.04095504,0.020237548,-0.010578482,-0.010449144,0.07142354,0.036665402,-0.028861536,-0.033178322,0.007697502,0.08393226,-0.03690169,0.026273746,-0.027858835,-0.005581614,-0.07074244,-0.021401875,0.039134793,-0.07313159,0.053791836,0.07442539,-0.068674035,0.0052022063,0.0018535312,-0.049484022,0.053616025,0.019357564,-0.010876668,-0.0018978441,-0.07558576,-0.02121077,0.07015598,0.08162817,0.023616,-0.011715918,-0.082110204,-0.027346857,-0.010390804,0.050320715,-0.0016533954,0.023702353,-0.01753538,0.0069307466,0.052636705,-0.050080482,0.07759182,-0.0024981543,0.033704534,-0.047805328,0.051292177,-0.07438204,0.019769168,-0.036969792,0.024204876,-0.03645038,-0.083070554,0.04359702,-0.045643363,0.006444704,-0.04374396,0.08806086,0.017781697,-0.042452846,0.0032755125,0.026557261,-0.0047335345,0.012818915,0.042929858,0.04573652,0.040380225,-0.059600413,-0.0036042868,0.055018943,0.0038580182,0.023752436,0.05067502,0.04661889,0.001915032,-0.015461498,-0.08360135,0.020920452,0.017424166,0.07633691,0.012463209,-0.010551863,0.0063433475,-0.0068223015,-0.024968665,-0.084358744,-0.06361815,-0.05130513,-0.008540386,0.08458379,-0.023154063,0.054466393,-0.015833227,0.00079067715,0.0056847706,-0.021119582,0.019196909,0.05407052,0.090328306,-0.022691302,-0.12770386,0.029750459,-0.012236786,-0.004002114,0.0034357444,0.057008795,0.020726334,-0.031524565,-0.1738191,3.8988183e-33,0.096066706,0.083483316,0.07281808,-0.03662629,0.009089128,-0.04441608,-0.06402642,-0.0011503607,0.014743285,0.00025393302,-0.07740876,-0.09040174,0.07455426,-0.105942965,-0.079228126,-0.0100083845,-0.07172449,0.022724938,0.12068413,0.048490476,0.037031002,0.02014922,-0.024486927,0.025761632,-0.029225674,0.112196304,0.018188935,-0.06733256,-0.025284965,-0.00835049,0.028458728,-0.107922696,-0.10460268,-0.056471143,0.165943,-0.08685495,-0.01354535,-0.01655437,-0.058632445,-0.019379528,-0.07836981,0.00712934,-0.008975214,0.009948914,0.059265688,-0.03393876,-0.11570915,0.071674876,0.027740404,-0.0013873002,0.0044346633,-0.047431055,0.07170819,0.014929192,-0.0669883,0.002428216,-0.01224547,0.023381831,0.0010503685,0.016472418,0.068887696,-0.005341411,-0.03767798,0.026700193,-0.0535299,0.004397821,-0.022766365,0.016568158,0.07673448,0.063410915,-0.011876713,-0.014196326,0.034719132,0.05617646,-0.030414715,-0.012523949,-0.05913534,-0.06084368,0.06960974,0.0457999,-0.061285637,-0.06831353,-0.059569556,-0.06981292,-0.053322084,-0.059286904,-0.05426046,-0.038469672,0.014412229,-0.005020321,-0.0026253024,-0.017955134,-0.059401523,-0.000503635,-0.021484664,-5.113103e-33,0.10871272,-0.015879318,0.09876525,-0.061066642,-0.028527591,-0.0016776334,-0.021900864,-0.009611683,0.028920958,-0.006057416,0.069332965,-0.0035526713,0.0051236213,0.00053904444,0.0050028577,0.04398445,0.054124746,0.014314551,0.046337508,-0.023226777,-0.03631042,-0.008721804,-0.021138959,0.03151906,-0.0058259787,0.010825123,-0.012699009,0.011322979,0.0677786,0.104230374,0.014014819,0.04596625,-0.035097327,-0.12092674,-0.05920837,0.011588636,-0.06755918,-0.010628537,0.05961597,0.02876595,0.08407506,-0.04392596,0.01710445,0.14282295,-0.0020545574,-0.022062834,-0.033511475,-4.274395e-05,0.018380221,-0.03658715,0.08210896,-0.011435178,-0.006416901,0.0265818,0.036506336,0.095861025,0.029469298,0.05465588,-0.0062344847,0.040149644,-0.0016335531,-0.121210605,-0.038979854,-0.0040929946,-0.02037945,0.096944906,0.044715855,0.04662589,0.029596923,0.020011185,0.0062340964,0.004953286,0.04986575,0.042841297,-0.042463854,0.012339803,0.007262762,0.08690237,-0.014969037,0.03693456,-0.021713234,0.03350216,-0.012884584,-0.10099192,0.09980568,-0.06681246,0.042463362,0.064550854,-0.061034147,-0.0221003,-0.05450929,-0.019064268,0.030464234,0.024933442,-0.053406026,-4.343119e-08,-0.017831642,-0.06184198,0.019561425,-0.04113281,-0.029412186,0.048399594,0.015411437,0.0030377991,-0.010484404,0.029460829,0.06212833,0.0642385,0.01761903,0.022815015,0.11558538,0.040852677,-0.007461557,-0.028287208,-0.024865631,-0.045235578,-0.03916524,-0.026562477,-0.13172185,0.016702315,-0.013325574,-0.089419514,0.008035903,-0.05142321,-0.043867946,-0.013593356,0.047418848,0.021261035,0.022980362,-0.021462781,-0.05483786,0.056721542,-0.063986,-0.06868374,0.0060490984,-0.07050661,-0.07334256,0.06023695,-0.08894329,-0.0020874564,0.015549968,0.0049440153,-0.035068832,0.09456022,-0.063356854,0.0039229603,0.044708084,-0.015477008,0.005957647,-0.073120445,-0.02816202,0.11631335,0.10404645,-0.036142632,0.018621774,0.026878072,-0.0044528395,-0.09241794,0.08330667,-0.080108754 +2.8.2.1,A number of aromatic compounds can act as acceptors. Organic hydroxylamines are not substrates (cf. EC 2.8.2.9 tyrosine-ester sulfotransferase).,384,0.99999994,-0.036277965,-0.111919336,-0.05245611,-0.06995309,0.018508296,0.00041032737,0.050936036,-0.03202111,0.04013501,-0.0610944,0.09700555,-0.022487048,-0.055839457,0.0675343,0.0032021217,0.089185,-0.03317615,-0.053887285,0.03462933,0.06401102,-0.011201022,0.02567187,-4.8918035e-05,0.012297664,-0.034124568,-0.0011107649,-0.03680656,-0.009345723,0.015548963,-0.043027245,0.014982529,0.06377659,-0.047833752,0.01733521,0.0011764541,0.027356105,-0.07997017,-0.04685513,0.03409158,0.030434545,0.063083366,-0.09794173,-0.043378018,-0.0847981,-0.027478024,-0.10419835,0.04220512,-0.022644429,0.013182191,-0.10290262,-0.029774327,0.03556273,0.018948471,0.05922827,-0.06123259,0.049421754,-0.030818066,-0.00054058107,-0.08680761,0.0147539275,-0.055275425,0.003354377,-0.036479272,-0.036517676,-0.016376948,-0.02305323,-0.0032288912,-0.023736037,0.056094818,-0.02820693,-0.06280811,-0.06702548,0.021169208,0.057521693,0.036454294,0.023578748,-0.028000316,0.024890851,0.063583456,-0.040729962,-0.053889595,-0.02133954,0.013926844,0.088250466,0.085400864,-0.05216596,-0.03656518,0.08069538,-0.003284929,0.06905981,0.0021766666,-0.029749854,0.045156322,0.026594875,0.007873273,-0.03961966,0.09672641,0.0397402,0.048103265,0.011812173,0.01054494,0.0002777341,-0.1132192,-0.06259845,-0.1277601,0.024631709,0.076015756,0.016536651,0.0057109296,-0.085871495,-0.074564844,-0.058841188,0.07450616,-4.364653e-05,-0.061447736,-0.018120605,0.05832431,-0.09474897,0.00073350273,-0.07340046,-0.09173801,0.04029287,0.08537315,0.026304571,-0.009537018,0.055826593,-0.049276255,1.2523926e-33,0.019408641,0.039717343,0.042471834,-0.0363376,-0.094812915,0.053938184,-0.08497745,-0.0017741346,0.06165618,-0.122837454,-0.05361554,-0.022528073,-0.022497693,0.10513886,0.06786288,-0.029124679,0.02443088,0.07175806,0.11082546,-0.049302775,-0.0054324614,0.031892724,-0.07102663,-0.08778397,-0.062222656,-0.0042515662,-0.06430687,0.021690328,-0.026299605,0.0072220764,0.063792,-0.034188874,0.038086805,0.03946769,0.017032795,0.06520689,-0.018718308,0.023064263,-0.029044962,-0.07254055,-0.06300176,0.026577631,-0.0033860086,0.0010187189,-0.005403036,0.04786398,-0.023298018,0.010532306,0.014248151,0.009795589,0.0037603083,-0.030737747,-0.00405574,-0.08003118,0.028607626,0.02365099,0.0065760924,0.012392949,0.021033447,0.010317981,-0.06851879,0.052162006,-0.09452624,-0.062385183,-0.046409436,0.011266236,0.014548818,-0.0011982358,-0.054277126,0.04749347,-0.024375346,0.028765935,0.043716963,0.0865362,0.11107036,-0.021316566,-0.05309321,-0.045005202,0.046328124,0.053779665,-0.021018203,-0.05279696,0.013092069,0.04181881,-0.09338809,0.0221722,0.06654986,-0.028574532,0.07200792,0.09282141,-0.00781465,-0.09218395,0.005134135,0.017185451,0.05221408,-3.3727806e-33,0.054017514,-0.0031880552,-0.0033102154,-0.07640686,0.02243887,0.0721644,0.08768665,-0.00893928,0.10328677,0.024921972,0.09314557,0.04257548,0.034449834,-0.0498642,-0.020126382,-0.067415126,-0.044739015,0.059734154,0.020996079,-0.015369633,0.008742722,0.027070545,-0.026009602,0.07944795,-0.015562426,0.06597816,-0.042472288,0.052585687,0.041200753,0.03571907,-0.03577696,0.012703727,0.020559749,-0.02874752,0.062045433,0.060934052,-0.10338044,0.02511287,-0.07646792,-0.005436607,0.011714867,-0.0074010617,0.027269589,0.048467517,-0.014943241,0.026397534,-0.012643488,-0.030567624,-0.016022317,-0.028902434,-0.013937985,0.0815362,0.03951085,-0.03754565,0.088187434,0.053910468,0.019076908,-0.081754334,0.031967662,-0.027508792,-0.060558897,-0.007003334,0.005034271,-0.058930244,-0.010348421,-0.01783225,-0.041293018,0.076075,0.028183054,-0.046616755,0.10422945,-0.029286634,0.03469987,0.014061998,0.04757795,-0.047182865,-0.08463081,-0.02832151,-0.021919196,-0.053251233,0.04601875,0.041810043,0.024256518,-0.10361107,0.018260634,-0.019664707,-0.0019438332,-0.06779191,-0.022544518,0.020636918,0.06975739,0.03270148,-0.018753618,0.07198625,0.033827197,-3.4791817e-08,-0.036722884,-0.036109857,0.089156404,-0.029979287,-0.07904882,-0.00067827094,0.036947716,0.006495345,0.018535972,0.011677383,0.047985166,0.04951835,0.033000335,0.0024376889,0.032701466,-0.04312172,-0.07139121,-0.030696247,-0.042664647,-0.038021516,-0.06916469,0.007113172,-0.08777436,0.0036953231,0.011896981,-0.018030856,-0.0155430455,0.02312629,0.016523026,-0.0126711335,0.1037986,0.031539217,-0.00033407216,0.036815703,0.015921688,0.022286981,0.017115774,-0.082986645,-0.045624934,0.018325051,0.005914274,-0.06648803,-0.07612176,-0.010057118,0.116359696,0.060279973,-0.04465786,0.027329678,-0.041439157,0.027976718,0.06847092,-0.048115585,0.057094306,-0.044140585,-0.050037354,-0.047379352,-0.017816437,0.015039464,-0.026616083,-0.08602586,0.03583539,0.009760419,0.20073596,0.02763145 +2.8.2.2,"Primary and secondary alcohols, including aliphatic alcohols, ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15 steroid sulfotransferase).",384,0.99999994,-0.0012385761,-0.041762583,-0.095102236,-0.03568718,0.032096215,0.034546413,-0.03886073,0.003629137,0.021048391,-0.05745057,0.08606516,-0.0052591097,-0.13173436,0.055280756,0.02270422,0.04654421,-0.051504165,0.052941974,0.08006549,0.028210811,-0.05902216,-0.02279698,0.030465592,-0.018178469,-0.0027037796,0.053021085,0.012420534,0.07934165,-0.009467159,-0.07201026,-0.0031962784,0.0056213243,0.043518886,-0.016105687,0.005624978,-0.020507028,-0.051495787,-0.06611908,0.03052946,0.053989794,0.047898803,-0.02967317,-0.054884173,0.038657155,-0.054655217,-0.057241812,-0.03603917,0.068562455,-0.014095078,-0.08069102,0.0586532,3.9494564e-05,0.05995995,0.094492584,-0.007137652,0.027864836,-0.079153895,-0.029828953,-0.020664658,0.06277781,-0.014629356,-0.011011877,-0.05434667,-0.02616988,-0.08148487,0.02714712,-0.04753578,0.0049998784,-0.00010135365,0.03524265,-0.033480927,-0.06910202,0.03269004,0.06431638,-0.0063340454,0.04844683,-0.013409695,0.01968646,0.045492098,-0.0043098736,-0.08041844,-0.033466835,-0.04440942,0.05235387,0.09421175,-0.087306134,-0.083990246,0.03262366,-0.07296648,0.14639033,-0.017480943,-0.017165655,0.092740074,-0.057471976,0.014224826,0.028217567,0.07251126,0.0011849208,0.003292414,-0.040530335,-0.01967133,0.034349173,-0.0121660475,-0.04779294,-0.025198208,0.03039727,0.00022330643,-0.04243964,-0.0025669204,-0.050294746,-0.0539865,-0.036504302,0.06344001,-0.060080986,0.024666276,0.09587263,0.031633534,-0.042288866,-0.019839603,-0.10204559,-0.08814273,0.014906588,0.047875587,0.034468777,0.005595719,0.028819982,0.014400648,2.7055529e-33,0.057783894,0.03300945,-0.018497724,-0.04671318,-0.06764422,0.031692833,-0.05681583,0.0731784,0.0036801498,-0.13361324,-0.06577614,-0.0033824744,0.039729744,0.06804665,0.05764776,-0.053418484,0.1000472,0.07970598,0.14100885,-0.06672787,-0.03047042,0.020594848,-0.06673337,-0.011890411,-0.07403272,0.046682484,0.013980229,-0.01905468,0.02130186,0.0025433651,-0.008747312,-0.0037870517,0.078663856,0.046252493,-0.05668231,0.06670469,0.011505319,0.0031627798,-0.0369,-0.03404822,0.027290503,0.028156284,0.0055099847,0.04072228,0.0046147634,-0.032352816,-0.08878452,-0.029716074,0.0610805,0.0284452,-0.013003212,0.005705054,-0.010425883,-0.0027630785,-0.028515544,0.07958149,-0.01672199,0.024119731,-0.018961255,-0.016556373,-0.05120653,0.10067825,-0.059202567,-0.009628289,-0.0797615,0.0532967,-0.034974247,-0.114000656,-0.096923344,0.0027060683,-0.031065427,0.010403866,-0.002523641,0.030904785,0.050380602,0.05226452,0.03318504,0.022444785,0.011206733,-0.0039850073,-0.11644201,-0.029552141,-0.010209887,0.07034945,-0.03968011,-0.011635049,0.0060324906,-0.048041865,0.06619561,0.03673042,-0.050931383,-0.05232222,-0.030159002,0.06126316,0.04532296,-3.9835446e-33,0.043509096,-0.10944073,0.034309532,-0.086648576,0.026922135,0.1183753,0.02775003,-0.07745146,0.045425095,-0.0038763476,0.028198665,-0.04145838,0.0012286253,-0.082344435,0.005848591,-0.01987522,-0.058529887,0.07754248,-0.02634147,0.002331854,0.03691547,0.06551245,0.04641305,0.025025064,0.00040798503,0.024885545,-0.030195845,-0.0070932326,0.02051028,0.040214248,0.04045515,0.01861651,-0.008012224,-0.023727171,0.06484827,0.04409735,-0.10718329,-0.0010290786,-0.1231256,0.025632435,-0.0069076126,-0.023968145,-0.036145862,0.052916553,0.07264866,0.023047471,-0.0046143415,-0.008715267,-0.01942201,-0.04756992,-0.027410666,0.07237109,-0.038351282,0.099010766,0.06355555,0.04189401,0.0065062763,-0.061989345,0.042324834,-0.046632387,0.0010567406,0.0011782234,-0.0064573386,-0.08094121,0.01936518,-0.09036194,-0.058863483,0.0444755,-0.06527414,-0.02434818,0.061693892,-0.044844024,0.012444545,0.12574448,-0.021367949,-0.03930509,-0.054886352,-0.055603936,-0.022655206,0.011789339,-0.083337225,0.050836124,0.027161475,0.015144847,0.016887749,-0.01821545,0.03098313,-0.07089025,-0.026067125,0.08605984,0.046407092,0.02632982,-0.054745123,0.06192402,-0.004787879,-3.648166e-08,-0.011129165,0.017168997,0.06603304,0.033948835,-0.04896779,-0.0468779,0.013618698,-0.022819377,-0.0051445807,-0.0355952,-0.029703917,0.046036426,0.09090072,-0.0264517,0.025365483,-0.0070187086,0.03309659,-0.03797054,0.012987956,-0.029766338,-0.058623865,-0.0051947515,0.006955773,-0.037419006,-0.038547326,-0.016976649,-0.011822326,0.007888999,0.020495899,0.026570735,0.08030009,0.027507754,0.031770054,0.0011121054,0.089385346,0.08301545,0.062976174,-0.057348188,-0.087597944,0.06876463,-0.041563798,-0.13427053,-0.076032475,0.06803885,0.04721522,0.031504728,0.018332873,0.00384119,0.01254684,0.013125863,0.039904114,-0.040526517,0.034839217,-0.06740507,-0.048762325,0.04643973,-0.03175568,-0.053483974,-0.03949281,-0.078865275,0.031494424,0.019744651,0.1489698,0.09344493 +2.8.2.3,"A large number of primary and secondary amines can act as acceptors, including aniline, 2-naphthylamine, cyclohexylamine and octylamine.",384,1.0,-0.0055107865,-0.092854306,-0.0712061,-0.044023313,0.028492354,0.002542748,0.023617713,-0.044214167,0.042599667,0.062668115,0.055166308,0.010625473,-0.06296069,0.12140113,-0.00090152974,0.10506178,-0.081332505,-0.004299538,0.01434783,0.04488988,-0.03932467,0.02138309,-0.008274673,-0.0035528452,-0.09128391,0.086835325,-0.029900625,-3.841052e-05,0.041962877,-0.09026413,-0.041972443,-0.027955364,0.08424845,-0.00630251,0.022212848,0.042913344,-0.050728258,-0.013109212,-0.02502382,0.013415329,0.020693304,-0.040203076,0.039907936,-0.09426252,-0.03327435,-0.045725044,0.05107815,0.018224265,0.011503418,-0.051465157,0.067560315,0.020514064,0.046044543,0.10944568,0.0026553385,0.01525178,-0.12169969,-0.016139891,-0.044569362,0.02067698,-0.033155546,0.059998646,-0.08681318,-0.047992937,0.006765952,-0.020364922,-0.016562838,-0.0643582,-0.04121964,0.008483929,0.012200906,-0.083538555,0.059263203,-0.02530483,0.09284474,-0.051693887,0.019141318,-0.01555895,0.030026231,0.047182307,-0.06855521,-0.047101744,0.01701724,0.033596504,0.08098129,0.0320006,-0.09181877,0.070924595,0.015882779,0.058499914,-0.013319793,-0.012944922,0.10213715,-0.063129,0.048743527,-0.041125245,0.07532087,-0.01848589,0.040364403,0.01774842,0.021137783,-0.033549316,-0.10202986,-0.06350234,-0.057338025,-0.032086406,0.009729727,-0.02840566,0.045097567,0.0024587633,-0.056975704,-0.04777093,0.103628345,0.07810047,-0.008261349,0.03170505,-0.00831228,-0.006086826,0.039512157,-0.09307967,-0.05046628,0.037488196,0.02193652,0.03238824,-0.019261869,0.047584686,-0.06670624,5.315906e-34,0.040019438,0.05392907,-0.0035252324,0.004025195,-0.058334988,0.049929783,-0.03119651,0.0525202,0.06397235,-0.1163588,-0.10649938,0.031257324,0.0740596,0.08933256,0.016722042,-0.07687179,0.018046973,0.05202104,0.121687785,-0.087926425,-0.028592544,0.09480221,-0.03520462,0.041636832,-0.0080728335,0.01068843,-0.0015909523,-0.013390058,0.011561561,-0.019086076,0.025510611,0.0049464735,-0.036983438,0.042937167,0.00026542306,0.04963842,-0.036341213,0.053457256,-0.030064514,-0.035351403,-0.03360702,0.032272708,-0.07600651,0.04792979,-0.02144893,0.033933695,-0.029307993,0.013293262,-0.034229673,0.018325208,0.0072110887,-0.007726603,-0.0396504,-0.040298313,-0.082628384,0.036482025,-0.003835799,-0.017169701,0.03436681,0.008868474,-0.043524045,0.012239138,-0.029354602,-0.03969798,-0.046295732,-0.023315666,-0.011548909,-0.055665195,0.055709396,0.042279392,-0.06666586,0.0026479692,0.07222658,0.036481496,0.06170189,-0.041014172,-0.036498737,0.021654747,0.06982467,0.030377805,-0.010465594,-0.035578534,-0.0063220863,0.08585204,-0.077203125,-0.066240676,0.06671244,-0.07282098,0.009189449,0.030765329,0.010450493,-0.14534494,-0.02643418,-0.0150173735,0.08317925,-3.7392663e-33,0.09440715,-0.06428413,0.033208933,-0.0041845827,-0.0063192197,-0.0034659563,0.04705438,-0.10817137,0.03726821,-0.060400207,0.080943145,0.04143369,0.063643366,0.04671762,0.004039845,-0.0054036533,-0.02408781,0.064705916,0.036736395,-0.015212004,-6.977438e-05,0.0021561168,-0.0405934,-0.013773511,0.003392964,0.03020249,-0.048472095,-0.03865257,0.057280786,0.059625782,-0.061825786,0.019204726,-0.016569063,-0.06023339,0.05082115,0.06844533,-0.0663773,-0.033808276,-0.102506235,0.014549024,0.035080887,0.004935249,0.030616712,0.083057225,0.007890361,0.01730035,0.021208838,0.015315459,-0.10742572,-0.060623847,0.0017166117,0.050530866,-0.014652377,-0.035311013,0.09671992,0.019044772,0.029829578,-0.06571078,0.03238718,-0.002995554,-0.054378722,-0.023981567,0.012951346,-0.033805165,-0.030597083,-0.06806516,0.0003016795,-0.01132911,0.032145485,-0.039497457,0.06967892,-0.08465458,0.14600302,0.046644382,-0.038224526,-0.119110085,-0.04269672,-0.072284885,0.022147749,-0.054035336,-0.07305402,-0.022273825,0.09062702,0.000753933,0.009776288,0.0007838534,0.10314538,-0.008099349,-0.02169061,0.059724107,0.06603172,0.05724539,0.04980386,0.07650369,0.057803564,-3.5287986e-08,-0.018386576,-0.089526184,-0.002821404,-0.062957406,-0.024603287,0.04410933,-0.004481089,0.017115692,-0.010539607,-0.04348324,0.093895644,0.05610176,0.023902124,-0.018423641,0.021722078,0.021503907,-0.052342404,-0.050749592,-0.0061806603,-0.024964709,-0.13749161,0.012970145,-0.077841364,-0.05639744,-0.021449,0.0121160345,-0.07168957,0.0059863543,-0.0050004697,0.03198941,0.05170774,0.020180924,0.023628473,-0.08765358,0.038528495,0.07038247,0.021079024,-0.07656047,-0.011660541,-0.039184134,0.015960094,-0.07495046,-0.09254282,0.026425483,0.035831295,0.0069285086,-0.03411634,-0.018974606,-0.05115783,-0.029142804,0.012018122,-0.030382456,0.07031787,0.00499977,0.0055307397,-0.037327487,-0.05821294,-0.06393776,-0.00087354676,-0.030127205,0.02027348,0.06090523,0.07129731,0.026546277 +2.8.2.5,The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase.,384,1.0,-0.027541297,-0.11300541,-0.047037624,0.017458057,0.02886527,-0.003669243,-0.040823124,0.062277187,0.055729534,-0.04163701,0.055896476,0.07948603,-0.035451915,-0.0019866962,-0.13759941,0.0037939346,-0.06651483,0.00017309781,0.036125124,0.022429029,0.07865582,-0.06133277,0.02800164,0.007740747,0.03603331,0.013507902,0.011758582,-0.003907131,-0.05269485,-0.06297292,0.012829704,0.0055629145,0.02065951,-0.014464995,0.014752287,0.014808229,0.026102332,-0.04426701,0.011734344,-0.046568323,0.041730493,-0.0122413095,-0.0050779837,-0.0335417,0.083983146,-0.09924466,-0.011903334,-0.0053345454,0.07393908,0.0052988506,0.029478006,-0.0103251925,-0.026301527,0.034318104,0.048853695,0.045532368,-0.08275344,-0.09742422,0.10433597,0.014412675,0.057906482,0.049039915,0.018186904,-0.09228285,0.03169677,-0.08454595,0.13802902,-0.080956705,-0.018613312,0.06113236,-0.10152955,0.04067564,-0.01948426,0.009639296,0.014349537,0.11282064,-0.0763767,-0.01611657,0.037106864,-0.07154529,0.015158355,-0.00033359582,-0.012822386,0.11945595,0.008071301,-0.078589186,0.048289973,-0.0010748833,0.019658294,0.03573868,-0.013291821,-0.04001824,0.003997708,-0.016002929,-0.05569035,-0.047727082,0.00808231,0.12850942,-0.0015821351,0.011184837,0.05085185,-0.0038866405,-0.043462444,-0.08744061,0.007836801,0.01022194,0.0012678978,0.098627724,0.057573892,0.016140243,-0.020041998,-0.041147474,0.040801737,-0.013691554,-0.038904388,0.16424774,-0.045690417,-0.036945034,-0.052658524,0.056810327,0.018024122,0.046385612,0.0013535179,0.054456986,0.0005402945,0.008277292,-0.040394,2.6846825e-33,0.09596595,0.06291296,0.14325936,-0.012634637,-0.077745706,-0.026307994,-0.14268309,-0.0234557,0.02731276,-0.01927103,-0.025408428,0.0068675578,0.048864793,-0.032918483,-0.05465478,0.041178897,0.028500473,-0.008466339,0.029778652,-0.011817854,-0.005689557,0.05323802,-0.08203424,-0.051191665,0.067833096,-0.044087116,-0.027304195,0.023321934,0.04455993,0.032644637,0.00866036,-0.095909774,0.01910485,-0.01593264,0.053194776,-0.024771517,0.01381583,-0.047376998,0.027022416,0.01389048,0.0940515,-0.016361134,0.037812743,0.0031806955,0.022557369,-0.031232439,-0.0059131384,0.023459349,0.065682136,0.050723694,-0.042024113,-0.05298551,0.059735935,0.02768314,-0.001957262,0.0044501703,-0.050352506,-0.0462478,0.053965274,0.03818613,0.08325583,0.019472677,-0.07361102,-0.066342324,-0.042696226,0.035079688,-0.044946622,-0.0053951517,-0.05866259,-0.010353862,-0.083090425,-0.03753546,0.065162875,0.09578398,0.029737337,-0.020273987,-0.030676723,0.07563331,-0.016555328,-0.014830673,-0.11661039,0.025769638,-0.061315756,-0.025124969,-0.07720024,0.05064455,-0.017919773,-0.030020868,0.009276942,0.043480106,-0.05054389,-0.07347698,-0.0775739,0.018275298,-0.0421793,-3.318049e-33,-0.011057238,-0.01889956,0.012248826,-0.04836818,-0.040697217,0.036000594,0.08170549,0.003157581,0.0031107028,-0.044259813,0.08023314,-0.02392072,0.015417109,-0.10413794,0.06902466,0.073823296,-0.038011212,0.030636746,0.029658992,0.05031367,-0.03584521,0.05317948,0.01008276,0.07774461,0.03025696,0.031128693,0.09005701,-0.033574358,0.056408472,0.07189177,-0.05593425,-0.03240394,-0.08444967,-0.042992316,-0.08630212,-0.023969293,-0.07720111,-0.028664393,-0.03171653,0.0048511173,-0.05457256,0.0036819647,0.046629857,0.07435978,0.073312104,0.03281946,0.020213518,0.04865418,0.026090417,-0.04905671,0.054142788,0.0050137388,-0.015798809,0.067895114,0.024777256,0.09604679,0.0016012951,0.06494744,0.0433907,0.0039467136,-0.027504483,0.028535424,0.025397472,-0.15001191,-0.0076200445,0.06878646,-0.050749917,0.016331855,0.020296186,-0.084175825,-0.01482826,-0.04676104,0.03857897,0.028065657,0.02980067,-0.0057810745,-0.062330946,-0.0025949585,-0.04150544,-0.048308045,-0.011014071,0.045736067,-0.0025631841,-0.08002043,-0.016705038,0.02746121,0.04708414,0.052682456,-0.0029654165,0.014700015,-0.02180103,-0.027412312,-0.09207763,-0.0014839573,-0.04680302,-3.0955782e-08,0.061117165,-0.026446715,0.028800678,0.003936463,-0.027987665,0.012031134,-0.0013257208,0.010309534,0.00068313343,0.019229772,0.031411145,0.10118288,0.009230198,-0.010873953,-0.04048612,0.06645042,-0.0014356314,0.033234693,-0.034689147,-0.005441318,-0.04555313,-0.007096317,-0.051763706,0.024533002,0.029978449,-0.039166305,0.0050824727,-0.0024265724,-0.08320715,-0.08011415,0.10181863,0.0069994684,-0.07029402,-0.06070568,0.010861398,0.05419266,-0.033872273,-0.024785824,0.06359482,0.07426999,-0.013345913,-0.0111778835,-0.03069915,0.0438914,0.021951599,-0.0022009832,0.014294593,0.0670389,-0.05020231,0.05008006,-0.031189622,-0.055874027,-0.08543267,-0.11019877,-0.016703757,-0.035227492,0.056944594,-0.1062116,0.04261373,0.012714894,0.018340977,-0.06660323,0.08978151,0.025781076 +2.8.2.8,"The enzyme also catalyses the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent.",384,0.99999994,-0.039919376,-0.11437069,-0.041759565,0.019069567,0.019538091,0.019659532,-0.066968426,0.055562414,0.0036800497,-0.005987525,0.009548273,0.07166433,-0.04879386,0.06839543,-0.07078665,0.06704484,-0.05277629,0.028797407,0.021054626,-0.034585398,0.08000446,-0.10539558,-0.036119148,-0.02703959,0.016602658,0.055473607,0.035814002,-0.012440846,-0.050150234,-0.04190448,-0.044473704,-0.032488875,-0.0019079001,-0.023253633,0.008999023,0.04561053,-0.015093127,-0.046731323,-0.0109721925,-0.04963902,0.04587309,0.025284132,-0.019276576,-0.034636483,0.037622806,-0.12916572,-0.001037101,-0.018828496,0.05549226,0.006492564,-0.03490509,0.020177295,-0.0215027,-0.014882312,-0.0024923643,-0.012203382,-0.08472368,-0.030016534,0.0534469,0.0036020458,0.026968883,0.016600536,-0.054634374,-0.062923156,0.06831641,-0.048890136,0.05324863,-0.027477598,-0.030600285,0.041626908,-0.03731871,0.026141265,-0.034885686,0.024776543,0.043092825,0.057886694,-0.06973957,-0.033005435,0.03444886,-0.06557837,0.024651587,0.058584396,0.0022840055,0.12848222,0.041854244,0.013166014,0.043643348,-0.021215668,0.04217291,0.014770811,-0.007797913,-0.00017199513,-0.037275415,-0.029539663,-0.041714236,0.0125832725,-0.047140762,0.11962239,-0.0032823065,-0.0042321417,0.013208331,0.0122857895,-0.06345367,-0.13151135,-0.012662967,0.038359247,0.0070318473,0.12984554,0.053550042,0.017010188,-0.011744616,0.00884704,0.058244757,0.018934608,-0.048601232,0.17139454,0.025842652,-0.021874782,-0.09709776,0.06418729,0.02249142,0.031944282,0.0060212607,0.062991075,-0.033533253,0.008107984,-0.06981685,6.318446e-34,0.086898796,0.066187546,0.08557189,-0.025289908,-0.03684376,-0.034905385,-0.09618245,0.036908094,-0.022307362,0.035742503,-0.025903186,0.026518667,0.026576184,-0.0017783564,-0.038784586,0.003938106,0.04948703,0.012190245,0.049227193,0.03135751,0.010886848,0.06369306,-0.06453606,-0.000748041,0.02115918,-0.012181406,0.014838223,0.048827864,0.03557291,0.0014952706,0.03660215,-0.08693456,0.0060795043,-0.019746121,0.06457798,0.010181966,-0.013931515,-0.02660734,0.022367928,0.039537173,0.034481607,-0.0778514,0.013426553,-0.046594694,0.021326812,-0.06990854,-0.004530826,0.022232272,-0.0039913156,0.044025164,0.027105616,-0.0118871825,0.0709345,0.014703451,-0.049088407,0.012880383,-0.005303071,-0.06597859,0.05096866,0.048257727,0.028429331,-0.017786339,-0.08934873,-0.04394619,-0.018228903,0.011285721,-0.0067097377,0.0052706404,-0.023164589,0.043043457,-0.10422967,-0.013513049,0.011964982,0.05536792,0.018073874,-0.026291013,0.00580822,0.05201459,0.03088558,-0.040805742,-0.11936915,-0.010021338,-0.024597716,0.0026017057,-0.0826994,0.027275318,-0.0656868,-0.028012745,-0.015345293,0.023296185,-0.03754764,-0.074958846,-0.10442418,0.015609639,-0.052777547,-2.3531687e-33,0.008083321,-0.067673005,-0.04080195,-0.07652657,-0.08390033,0.033857808,0.07591097,0.024125563,0.02821627,-0.03768826,0.046761192,-0.004432579,0.04488741,-0.064475164,0.0045463205,0.12958385,-0.01239233,0.0025198197,-0.00042228503,-0.032846577,-0.04683564,0.181149,0.05100622,0.101354584,0.06723609,0.035184547,0.07116597,0.029047767,0.06835155,0.15026014,-0.016493734,-0.08530058,-0.04713142,-0.056597196,-0.07216987,0.040689517,-0.027937481,-0.030692039,0.022106988,0.0064628776,-0.040077303,-0.03683227,0.051669028,0.09503807,0.06343523,0.035366677,-0.048521057,0.08057769,0.019972783,-0.04445691,0.115727305,0.017809907,0.014843572,0.03033664,0.03364452,0.072733834,0.0065041366,-0.031031743,0.00092441036,0.012937849,-0.08401991,-0.037764434,0.018599343,-0.07386082,-0.011001638,0.09263736,-0.07359205,-0.05013535,-0.007130976,-0.0813628,0.025647094,0.0007962095,0.006839611,0.06149794,0.0016373126,0.00888518,-0.056486003,-0.03334657,-0.04182875,-0.00727002,-0.06369385,0.01887622,0.0013642061,-0.1252674,-0.012129057,-0.016296946,-0.012771984,0.078808084,0.054499328,0.04018091,-0.015626587,-0.02263475,-0.049878243,-0.01063721,-0.04719502,-2.6937679e-08,0.045581304,-0.026301673,0.052129492,-0.0020258452,-0.078856684,0.036129653,0.065320596,0.0042580455,0.012797051,0.0068579074,-0.004477726,0.104178,-0.032236658,0.021171737,0.01751863,0.05315286,-0.00777611,0.009361935,-0.06783367,-0.04296021,-0.057381403,-0.003973031,-0.11038022,0.07774864,0.05209151,-0.05772969,-0.019106979,-0.05132501,-0.07253022,-0.0092953,0.076030135,0.00936365,-0.055482414,-0.048072845,-0.012038587,0.041727193,-0.044467576,-0.045029666,0.03621435,0.04192026,0.004080827,0.022425387,-0.052582525,0.041610517,-0.020617425,-0.010265247,-0.0031662781,0.022239894,-0.004622601,0.07193173,0.042151064,-0.045275252,-0.04664436,-0.096998416,-0.05255401,-0.031131918,0.0674662,-0.08176869,0.021622831,-0.020608434,-0.015654169,-0.041897908,0.19395588,0.009031606 +2.8.2.9,Phenols and organic hydroxylamines can act as acceptors (cf. EC 2.8.2.1 aryl sulfotransferase).,384,1.0,-0.09848735,-0.112471804,-0.07823552,-0.009975168,0.011651532,0.036350556,0.020117193,-0.02856419,0.026331145,-0.047753856,0.1043546,-0.0057309573,-0.117787465,0.04653436,0.008741756,0.13181084,-0.10340169,0.03601569,-0.008288392,0.04104173,0.020399928,0.010208138,-0.024619771,0.024189346,-0.028341278,0.028112885,0.0019338353,-0.00040803137,-0.018576425,-0.063310854,0.04204779,0.02485802,-0.015125187,0.025339453,0.0071446984,0.03809605,-0.049111374,-0.09794542,0.014463195,0.0050520967,0.05573037,-0.10321136,-0.017894486,-0.04121109,-0.053538572,-0.09175518,0.035944384,0.031672593,0.047657337,-0.10097304,-0.047293104,0.029860595,0.0010336706,0.04571493,-0.02857988,0.12996908,-0.052396666,-0.018556288,-0.031463377,0.0016603209,-0.060540263,-0.026520658,-0.03954233,-0.009208458,-0.08376749,-0.014176674,0.03692611,-0.041088052,0.07827055,-0.0012752931,-0.10208382,-0.057642378,0.0075198314,0.03777189,0.029294496,0.070125625,-0.010614501,0.021622222,0.059313808,-0.0013130587,-0.029690204,0.00096994714,0.024702141,0.053140562,0.08858038,-0.05954794,-0.0010551402,0.07904619,0.01189792,0.062815346,0.0066926717,-0.030455504,0.08110142,0.018171838,-0.0036446871,0.012646419,0.1313992,0.0014215229,0.045279786,-0.014811704,0.016471056,0.01327604,-0.08280538,-0.07758031,-0.0697765,0.018093493,0.038931917,0.03705918,-0.010939883,-0.05897138,-0.053324975,-0.087002255,0.058090065,-0.005353139,-0.03549289,0.05763053,0.028867038,-0.082992196,-0.007602863,-0.080484234,-0.09758266,-0.013413606,0.037492815,0.0040365937,-0.04554229,0.059706766,-0.09464879,1.738369e-33,0.06794937,0.068233095,0.039312355,-0.019766932,-0.10571961,0.049394604,-0.13078088,0.043522663,0.04918164,-0.14677274,-0.072091386,-0.03601058,0.011167074,0.083614334,0.0010758396,-0.029505363,-0.017096197,0.042835318,0.11740405,-0.021465808,-0.0073910346,-0.00056892756,-0.07398538,-0.07553915,-0.05544054,0.012267413,-0.051375374,-0.0026232344,0.012033739,0.015664784,0.087096676,-0.073714055,0.019738654,0.05204003,-0.026558807,0.07313069,-0.021926897,-0.014603831,-0.010147235,-0.020625018,-0.056368567,0.009170601,-0.0052835876,-0.008313038,0.034105092,0.007895487,-0.041447558,-0.0061466256,0.035952557,0.06881822,-0.034586497,-0.03744837,0.003460193,-0.036203023,0.015720662,0.0028697022,0.0124439,0.0017608741,0.0035646122,-0.0099018,-0.057585146,0.08702251,-0.0196995,-0.0652994,-0.06101156,0.05454312,-0.0015035132,-0.026108723,-0.066215955,0.024094803,-0.03233428,0.030470008,0.050116707,0.04806367,0.090599746,-0.007643945,-0.010188747,-0.008849006,0.032585252,0.0737992,-0.07166169,-0.03288872,0.026129413,0.0717625,-0.0745339,-0.0065909903,0.034152176,-0.017028714,0.05670312,0.033879768,-0.020856868,-0.1009091,0.007521727,0.028983003,0.043894205,-2.8669984e-33,0.0828215,-0.038974706,-0.012536066,-0.055053428,0.013275291,0.047586855,0.04827752,-0.0093507,0.100934446,0.037876885,0.06681279,0.03302328,0.09872123,-0.06926329,0.045732632,-0.066934526,-0.036666457,0.0018924365,0.020561809,0.034743235,-0.00043940698,0.045207545,0.0027390667,0.071665056,0.030435793,0.047192004,-0.006189225,-0.025782194,0.057605084,0.039065287,-0.015029826,0.025815926,-0.018471375,-0.04239777,0.058955394,0.012410408,-0.10070485,0.030461444,-0.068768196,0.0025523796,0.00420391,-0.0063749715,0.0060789315,0.059935044,0.005545492,0.064445876,0.044621777,-0.0035289717,-0.0439939,-0.05737252,-0.0019059323,0.1267147,0.0054572495,0.033174403,0.054341137,0.051468957,0.030076921,-0.064587206,0.010439645,-0.03814572,-0.09442165,-0.06258307,0.038876347,-0.0769049,-0.026168916,0.00916953,-0.04664419,0.073153496,-0.023730207,-0.06113277,0.1043818,-0.05923372,0.037024975,0.08348694,0.05919355,-0.08852235,-0.08394369,-0.040666632,-0.0026454467,-0.023642685,0.02205608,0.0109737115,0.02281824,-0.08339842,0.035271354,-0.047197353,-0.006268962,-0.034933317,-0.017568622,0.052709896,0.038812157,0.037414,-0.05770797,0.08149601,0.041960593,-3.1770142e-08,-0.038164955,-0.017014125,0.071801536,-0.016369954,-0.018772144,0.028846344,0.0032982223,0.05316903,0.035641164,0.019224443,0.014121162,0.060290195,0.06439379,0.015767269,0.025211198,0.004520873,-0.0588519,-0.031803723,-0.017591376,-0.0122378655,-0.06788832,-0.02918056,-0.0688699,0.017794201,0.013235853,-0.025819207,0.023396458,-0.015716199,-0.032224182,-0.021831835,0.083728,0.048366725,-0.005934547,0.04831408,-0.0012423462,0.065042004,0.06034617,-0.07990335,-0.05771929,0.042059686,-0.041962385,-0.05996143,-0.0864562,-0.00036330882,0.07402368,0.031067073,0.010679366,0.013023953,-0.012815601,0.012853905,0.042904332,-0.08785677,0.03671779,-0.060052454,-0.06042498,-0.025996616,-0.013686376,-0.019732226,0.006305428,-0.039883703,0.020189168,0.022988822,0.15761307,0.03547673 +2.8.2.10,The product may be identical with Watasenia luciferin.,384,1.0,-0.06502135,0.009700948,-0.041808672,-0.029224047,0.0038666546,-0.01757234,0.006137566,0.041619625,0.020297458,-0.03941812,0.008920937,-0.027615769,-0.0069320165,0.06798394,-0.073915176,-0.024698064,-0.0058317278,0.03541315,-0.02012959,0.007918525,0.05334957,0.08599919,0.06955073,0.028537745,-0.07043192,0.07801428,-0.04042294,0.04795313,0.041732904,-0.073053874,-0.017364696,0.01996136,-0.084540196,-0.05367983,-0.07744808,-0.010881752,-0.057912543,0.009866231,0.00095060427,0.030133108,0.03096876,-0.028788358,-0.095610455,0.019088505,-0.10963788,-0.03336764,-0.07911409,0.047326446,0.06847759,0.02854271,-0.027478784,-0.06981955,-0.0019226724,0.072638586,0.003900044,-0.038088094,-0.078079425,0.0019768593,0.0040183314,0.05337198,-0.00985267,0.043223936,-0.01823824,0.04129797,0.05761411,0.016249904,-0.036550865,-0.03135829,-0.06771553,-0.07287975,0.01539671,-0.024783228,-0.008476249,0.06455116,-0.067119114,0.091077305,0.03801138,-0.008737408,-0.014957044,0.05455614,0.01881802,0.028520867,0.018003257,0.1009828,0.054096784,0.005565995,-0.01660641,0.05097427,0.022439415,0.03272824,0.09145697,0.0017279476,-0.065377645,-0.0021667946,-0.035553668,0.017941993,-0.020927114,0.039604045,0.015714444,0.06955514,-0.12448522,-0.06196718,-0.03893312,-0.08719105,-0.08692388,-0.011482306,0.018477023,-0.005692473,0.05763798,-0.017036336,0.0021298476,-0.049785886,0.016352639,0.05125422,-0.06392721,0.07060569,0.039848253,0.018082194,-0.019215157,-0.016348792,0.06860716,0.019399107,0.14408016,0.10227307,-0.039621133,-0.004852762,-0.073992856,-1.3517558e-33,-0.0116089815,0.0085908845,0.012955251,0.06244329,0.045475718,-0.0016549255,-0.06846342,0.019034674,-0.03565693,-0.08226415,-0.11909507,0.0056891874,-0.016088944,0.0035602697,-0.055966888,-0.014184583,-0.010415976,-0.01202924,-0.01711268,-0.0014739161,0.07709158,0.08364401,0.028146924,0.027126525,-0.017583255,-0.04338101,-0.022544248,0.040714372,0.036351424,0.0059142364,0.010172389,-0.0834915,-0.013905337,-0.050541103,-0.046804227,0.09498171,-0.011677049,-0.11199793,-0.018422874,-0.027190357,0.062456902,0.025117753,0.033818197,0.035072487,0.059877526,-0.04907275,-0.06368137,0.008920846,0.017233364,0.023896122,-0.002919943,0.037008666,0.015523395,-0.05621631,-0.10804296,0.0144176865,0.022887336,0.041296985,0.08923228,0.044554103,-0.037066195,0.09467264,-0.019512413,-0.01640417,-0.037182644,-0.00203986,0.023628065,0.03447401,-0.075440936,0.041316155,0.0071906634,0.040046025,0.050354216,0.044143125,0.057831302,-0.06523998,0.006364054,-0.016872574,-0.067641295,-0.013297359,-0.0014500703,-0.03522513,0.07020863,0.036252175,-0.06260081,-0.018907888,-0.025851363,-0.036249433,-0.019232752,0.0031579684,0.10046793,0.043362543,-0.029876808,0.020641718,-0.025715914,6.4078755e-34,-0.0141543485,-0.11434884,0.134922,0.025464721,0.0043417397,0.053418007,-0.05069891,-0.0028058128,-0.047666207,-0.0121489875,0.14610574,-0.041791517,-0.029596534,-0.05609237,0.0018594769,0.0582057,0.034837365,0.064535655,-0.013714887,-0.025789946,-0.06661894,0.0716942,-0.046335824,-0.0022231464,0.024331626,0.008822831,0.119487755,0.08555994,-0.0053636758,0.015179545,-0.007857038,-0.036872562,-0.114796005,-0.05776841,-0.00049523404,0.04572344,0.01427002,-0.087379664,0.008655279,-0.049269125,0.002148196,-0.007821035,0.04201019,-0.018631192,-0.033792194,0.081193514,0.020439042,-0.03872717,0.10167607,0.040034123,0.056667347,-0.0011771441,-0.08395335,0.030999659,-0.038947105,-0.0063356957,0.054601263,-0.025370223,-0.012554442,0.044132657,0.09745043,-0.019657962,-0.010923274,-0.00079849875,0.034603387,0.051634543,0.00835505,0.086097464,0.015502247,0.021861156,0.047406465,-0.04913105,-0.031498156,0.03523745,0.011359424,-0.01571286,0.06138539,-0.085326426,-0.014270564,-0.051598098,0.010606658,0.015722299,-0.043392677,-0.045391556,0.05053772,0.06112688,0.019610861,0.06116027,-0.06547311,0.033993013,-0.027762476,0.03146782,-0.049401637,-0.020782799,0.12782204,-1.7807112e-08,0.06937069,-0.07326993,0.031757597,0.0154278865,-0.021503419,-0.049588215,-0.006482918,-0.0579097,-0.051536895,-0.0043431325,-0.04724468,0.06766499,-0.019147685,0.042470675,-0.014825582,-0.018599639,-0.08554199,0.048333216,-0.013348521,-0.037202753,-0.019062044,0.04571263,0.046647444,-0.021216858,-0.07512783,-0.05691153,-0.01834307,0.064861044,0.071177736,-0.098319694,0.0063803424,0.026928596,-0.011084193,-0.031835083,-0.11104372,0.00032101647,-0.06031271,0.024576085,-0.044379044,0.028970387,0.027587757,-0.10825286,0.043540884,0.013844294,-0.0063749673,-0.07376564,0.035526015,0.012685088,0.023404289,-0.030473342,0.100450635,0.10182212,0.043320958,-0.012891532,-0.089355476,-0.05021235,-0.009756818,-0.02847999,0.02246152,-0.050198227,0.0018370354,-0.11237251,0.16819452,0.030701695 +2.8.2.11,Also acts on lactosylceramide.,384,0.99999994,0.05835855,-0.12085047,-0.03687185,0.03292579,-0.010829789,-0.035694662,0.009712865,0.10666201,0.05363576,0.029098483,0.044377595,0.046226025,-0.027690079,0.08130455,-0.057370078,0.019728249,-0.005420059,0.066695176,0.042695355,0.05155147,0.04669989,0.010249391,0.042579968,0.042364184,-0.010792947,-0.011322146,0.07699018,0.0068996,-0.0044598654,-0.04032093,0.009311338,-0.026601287,-0.0040518027,-0.01691804,-0.0027964383,0.022394208,-0.05150834,0.026878424,0.002451117,-0.001426509,0.04528784,-0.10303084,0.041634027,0.021093285,0.021076031,-0.059153225,-0.014565288,0.0555781,0.06769021,0.11267185,-0.07560442,-0.0860431,-0.017038077,0.04860444,-0.0635173,0.0035352313,-0.10386047,-0.0015460303,0.054098655,-0.0068498724,-0.04792022,0.009487696,0.004062538,0.08150461,0.044819273,0.005927054,0.057624392,-0.08217323,-0.047212128,0.017155267,0.03690819,-0.114174604,0.08114507,0.008602226,0.005361883,0.044620696,0.00842637,-0.06975932,0.029348658,0.010866371,-0.017510828,0.012740272,-0.008218293,0.0817024,-3.089321e-05,0.015299427,0.08267026,-0.034565847,0.017737443,0.00807187,-0.020066831,0.0328409,-0.008871394,-0.0051512197,-0.10627161,-0.06384246,-0.058688566,0.058493294,-0.03152514,-0.027264653,-0.07687503,0.01699363,-0.072806984,-0.01873374,-0.089329585,0.038999055,0.0054319645,-0.03535829,-0.029911341,-0.04715355,-0.04784923,0.06914116,-0.010792485,0.043815933,-0.043156765,0.090831816,0.11000173,-0.04890404,-0.04185991,-0.025424082,-0.028586268,-0.06318129,0.019924542,-0.013238361,-0.039997596,0.019982666,0.029642044,-1.2893056e-33,0.019995186,-0.030705217,0.066493325,-0.014330394,0.061600458,0.003373777,-0.017713845,-0.08446434,-0.053767826,0.020351008,-0.012892178,-0.08330612,0.08573019,0.057989616,0.020788668,0.00916074,0.010599235,-0.008901916,0.051906142,-0.047564033,0.011594172,0.13796012,-0.037901852,0.0084679965,-0.03871235,0.06289985,-0.01745879,0.06079371,0.007737791,-0.008120748,0.036321655,-0.0041806633,-0.061700836,0.06513259,-0.016203066,0.16002753,-0.035809185,-0.019260552,0.019432718,0.04508531,-0.035960246,0.006009535,-0.03493055,-0.031088447,0.030529698,-0.07866369,-0.097812176,0.04635847,0.022198087,0.03463127,0.0945609,-0.043529883,0.059476517,0.020830158,-0.007822691,0.047748707,-0.06537462,-0.026948627,0.074124336,0.0671163,0.02384292,-0.018486243,-0.016687097,0.022718646,-0.0060091466,0.0062242257,-0.04422192,-0.09060075,-0.072601624,-0.010954126,-0.067279294,-0.026384646,0.09794336,0.01840012,-0.01741498,0.019389749,-0.04143546,-0.02994114,-0.03557997,0.015558668,-0.013825015,-0.1531062,0.055962607,0.032701664,-0.0004364146,0.019305311,-0.09020976,-0.05532645,-0.0326127,0.015917731,0.07319426,-0.06780924,-0.06334501,-0.0037606366,-0.016928673,-5.247276e-34,0.030121362,-0.07465294,0.024517668,0.008353032,-0.04976173,-0.008593115,-0.0088476725,0.04038234,0.022785032,-0.043188654,0.061347354,-0.046760518,-0.0767451,-0.018565586,-0.03394466,0.07741884,0.088166595,0.005270855,-0.05845844,0.007943504,0.005158331,0.1368189,0.013405645,0.046812695,0.07628392,0.048763577,0.031790927,0.022993939,-0.03532919,0.03185707,-0.026190976,0.021743601,-0.078903705,-0.13095894,-0.038502954,0.028306615,-0.030566113,-0.046892375,-0.020950096,-0.04859407,-0.028349096,-0.008628914,0.064464256,0.08614116,0.03387414,0.0502658,-0.012132198,-0.04105233,-0.025164388,-0.015132288,-0.038215432,0.004992902,0.043817688,0.060034513,0.09249523,0.077045776,0.02350862,-0.1079495,0.030996826,0.014064986,0.050051264,0.045098707,-0.04282688,-0.10972033,0.11564047,0.012485906,-0.098091036,-0.0205106,0.06686777,-0.025296941,0.079056166,0.022284353,-0.05397293,0.0802424,-0.10634221,-0.005059254,-0.012301749,-0.06757926,-0.015327541,-0.0052351714,-0.024671115,-0.022234386,0.04055493,0.01570152,0.0054577244,-0.020762946,-0.056520633,0.02685247,-0.029383367,0.016307201,-0.028292216,-0.034548987,-0.025756659,0.031110944,0.02600761,-1.6568295e-08,0.013038732,-0.04246569,0.024147263,-0.0897693,-0.053164836,-0.0047810627,0.029526453,0.030901236,0.03688261,-0.049662538,-0.050541993,0.16264325,0.09662809,0.03417793,-0.003707899,-0.0148408115,0.018691596,-0.041951787,-0.07330922,-0.061254974,-0.123574875,-0.061116662,0.0016856309,0.03691108,-0.0015146866,-0.028999452,0.05287747,0.103360176,-0.025125906,-0.035486292,-0.015257813,-0.015702635,0.039870586,-0.039801005,0.020786254,0.07910346,-0.020228555,-0.048094332,0.043029264,0.02172239,0.0032751332,-0.013888755,0.012413073,0.045386292,-0.0129202185,0.009778057,-0.02760376,-0.014799996,0.007475594,-0.041527618,0.021493537,0.01625003,-0.054217443,0.012571519,-0.022620993,0.0052008685,0.036105655,-0.032831136,0.07112578,-0.058734514,0.038250994,-0.058479622,0.1288492,-0.01850267 +2.8.2.14,"The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3].",384,1.0,0.02644198,-0.107923225,-0.03689988,-0.09068168,-0.017506884,0.049298227,-0.09342596,0.065432064,0.037501916,-0.06384266,0.040360183,0.004755185,-0.07144194,-0.03307123,-0.06334796,0.045485884,-0.014066445,0.027970273,-0.029317742,-0.060789384,0.058870334,-0.04027823,-0.0014280382,0.024381623,-0.021126606,0.035395987,0.048687883,0.022296403,-0.057753768,-0.070048936,0.021125844,-0.048626002,0.056718674,-0.06339125,-0.07234117,0.031620406,-0.047824483,-0.056625232,0.02116233,0.026697097,0.010814555,0.00055762846,-0.09502337,-0.05603053,-0.00968327,-0.10030329,-0.0022451214,-0.007618303,0.061750732,-0.0025784238,-0.003376486,-0.0034385177,0.019943194,-0.03826677,0.050715238,-0.010246355,-0.04606408,-0.024943033,-0.0099154785,0.004307458,-0.04461296,0.027980093,0.0795009,-0.05889768,-0.016615327,0.018135084,0.074638374,-0.08488596,0.023795996,-0.013716261,-0.1371921,-0.08006653,-0.0007098135,0.05375798,-0.06811349,0.082335725,-0.032975648,-0.071184486,0.040842887,-0.033323,-0.025827214,-0.034934875,0.017853424,0.10075391,0.048582926,-0.09755331,0.036765482,-0.023407547,-0.027366022,0.06656893,0.0067246645,-0.025517825,-0.017255737,0.002641687,0.042105053,0.03464757,0.015326838,0.055091046,-0.0011341192,-0.036252417,0.038902394,0.06953539,-0.03941706,-0.12203008,-0.01072445,-0.012834606,0.052972704,0.06648297,-0.01058696,-0.020519119,0.018591877,-0.034717694,-0.0010903708,-0.07965765,-0.11754106,0.16951284,-0.0052654175,-0.065813415,-0.02695213,0.06438162,0.01849704,0.041591577,0.039962955,0.03786704,0.020878494,0.017061107,-0.025635673,2.5611357e-33,0.054623418,0.041112848,0.021442393,0.010953604,-0.017629998,-0.009385458,-0.08587001,0.10800369,0.055167586,-0.08759116,0.040232517,0.012936529,0.023069382,-0.021714313,0.02788299,0.04998782,0.035883747,-0.019267457,0.066265136,-0.012757421,-0.0030377305,-0.05893494,-0.025209382,-0.060029514,0.008856784,-0.012474035,-0.03144187,0.01603382,0.04565579,0.03119901,-0.010095762,-0.095474325,-0.016221307,0.028112674,0.03358477,0.031305633,-0.06327471,0.020233238,0.0086258575,0.048676264,0.07712687,-0.03276254,0.050568484,-0.00586287,0.043890473,-0.0075590266,-0.07529478,0.05494574,0.094074704,0.05269303,0.031062257,-0.06031489,0.058039792,0.014120911,0.03757257,0.0024426763,-0.042840905,-0.02809538,-0.04458706,0.06910177,-0.015135436,0.14007396,-0.041635815,-0.02112071,-0.009914239,-0.016974589,-0.060509324,-0.010329013,-0.11599923,-0.0706593,-0.056639604,-0.015600007,0.08186222,0.029267805,-0.04593495,0.016421545,-0.02034359,0.06523567,0.029919637,-0.010702071,-0.06409772,0.009760843,-0.012747672,-0.060202077,-0.112649776,0.08109386,-0.033926755,-0.033062644,-0.019529643,0.0762921,-0.09600117,0.00061762606,-0.097327486,0.024031553,0.012399587,-6.468209e-33,0.019106958,-0.052439056,-0.0015498196,-0.06865977,-0.02148231,0.08508323,0.055325776,-0.019637864,0.061132576,-0.018736333,0.016200762,0.015768973,0.06978167,-0.10655605,0.026254632,0.029469468,-0.010462303,0.075082436,-0.049953815,-0.037991673,0.032027286,0.11945177,0.040979017,0.11398421,0.048678778,0.00041601137,0.060825266,-0.039066583,0.048247904,0.10205143,0.036964666,0.033487074,-0.01316747,0.006593166,-0.03978729,0.012193172,-0.06819264,-0.06119394,-0.035831988,-0.0017436796,-0.04834471,0.031767745,0.07445089,0.026900433,0.069209695,0.0678717,0.026132254,0.0030499315,0.046367586,-0.026789678,0.021008005,-0.020768937,-0.0715382,0.075789705,0.01770968,0.09745074,-0.05174625,-0.018872093,0.030440575,-0.06194066,-0.06408072,0.015011067,0.023026723,-0.056755345,-0.053521972,-0.021282595,-0.05501118,-0.034469485,0.014641089,-0.0046236548,0.03557694,-0.03123464,-0.055948578,0.016582511,-0.03349826,0.022005549,-0.037611917,0.023038639,-0.031997286,-0.07478402,0.035163973,0.069572516,-0.004518176,-0.035488266,0.018548297,-0.07932059,-0.056424193,0.06867262,-0.014357583,-0.007065704,-0.017347032,-0.0145363845,-0.15544873,-0.01769066,-0.05022798,-4.6545395e-08,0.082812026,-0.021053813,0.024646886,0.053732943,-0.007982652,-0.012041967,0.0333333,-0.003920023,0.03112931,0.009980578,-0.0014870022,0.13779633,-0.02963119,-0.010173737,-0.013770632,0.010089952,-0.004737203,0.028043345,-0.002016617,-0.010319341,-0.087278105,-0.05703701,-0.04847804,0.008325044,0.020117827,-0.051080644,0.05786469,-0.05397938,-0.02589444,-6.432202e-05,0.07602864,0.030746017,-0.044344634,-0.016186755,0.010101244,9.54517e-05,-0.023262242,0.026473053,-0.010146683,0.07712279,-0.05194956,-0.053864382,-0.07096266,0.03487987,0.06468339,-0.0025712322,0.0067322445,0.08699916,-0.010325211,0.027969308,-0.0073607946,-0.008188158,0.027594639,-0.03998389,-0.030833323,-0.004475283,0.027514702,-0.11763095,-0.0053112116,-0.020627439,0.049614158,-0.026104977,0.1775625,0.029521314 +2.8.2.15,"Broad specificity resembling EC 2.8.2.2 alcohol sulfotransferase, but also acts on estrone.",384,1.0,-0.059609823,-0.06136231,-0.09452125,0.011713786,-0.0006409382,0.036013488,-0.05280593,0.090323046,0.047976505,-0.11193387,0.112337224,-0.06009276,-0.1817314,0.048722457,-0.043434083,0.08315749,-0.07780756,-0.01926481,0.0452156,0.024627294,0.06923646,0.033785056,-0.0075138384,0.0343056,0.009662744,0.08288675,0.041667674,0.04532716,-0.015519087,-0.08357278,0.062732086,0.021681486,-0.01932452,-0.035774242,0.065051824,0.011703803,0.0073550614,-0.070591785,0.030631028,-0.016958667,0.07413141,-0.033443343,-0.044292834,0.051154003,0.02019304,-0.06413096,-0.018129839,0.049023796,0.013065955,-0.05635065,0.014802469,-0.06681879,-0.019785749,0.03496463,0.038001504,-0.081893474,-0.025323143,0.024461709,0.025458412,0.021436349,0.0080251,0.050130215,0.05932791,0.020572683,-0.028376605,0.018908577,0.06516007,-0.0683726,-0.00016714618,0.0022836116,-0.08421621,-0.05954,-0.029933853,0.10082273,0.0072266976,-0.0010136433,-0.0243476,-0.031461205,0.016708711,-0.005114079,0.00382149,-0.004336992,0.03466529,0.04857415,0.031222992,-0.07267464,-0.028570227,-0.036175173,0.019162564,0.060979955,-0.01651359,-0.045376096,0.03241717,-0.018063337,0.05733568,0.055809386,0.0035980132,0.12437264,-0.020519253,-0.01255307,0.011469321,0.08452822,-0.1481157,-0.05609826,-0.05872444,0.026118916,0.11002085,-0.0020372143,-0.016630132,-0.038264,-0.03398847,-0.06846888,0.01243896,-0.08216929,-0.061733812,0.12332755,-0.0007166415,0.015533681,-0.0007403554,0.002996081,-0.027050035,0.0148583995,0.026885603,0.07329376,0.01021287,0.051398344,-0.124733865,8.96224e-34,0.054833192,0.050682466,0.024382023,0.025398176,-0.028485091,-0.06390755,-0.11012707,0.011524859,-0.026475042,-0.0526007,-0.06697341,-0.06831227,-0.0038947894,0.0023816044,0.06580289,-0.078155786,0.0443812,0.008759519,0.043923106,-0.01863797,0.006520892,-0.012551234,-0.006376944,-0.048821367,0.01322655,0.037935603,0.04238726,0.049144305,0.03750787,0.002225237,-0.03139106,-0.07537199,-0.025611041,0.03673504,0.038922068,0.0071449205,-0.0085482225,-0.043115035,-0.0092124175,0.03589823,0.03786181,0.075350225,0.055821173,-0.031925555,0.018598871,-0.082578674,-0.050327554,0.07392077,0.08092333,0.036168296,-0.042168196,-0.048750333,0.086192995,0.011233199,-0.003666252,0.000354804,-0.046516087,0.018293373,-0.0015124069,0.0008037224,0.021750996,0.05955665,-0.03527767,-0.08797401,-0.06282999,0.0654097,-0.08303439,-0.053234752,-0.04276113,-0.0008382259,-0.0375871,0.019060839,0.08456987,0.02825369,0.050853834,-0.0010668369,-0.017775,0.013266964,-0.008974904,0.0119237555,-0.118808456,-0.07457314,0.0026718557,5.114343e-05,-0.067181386,-0.011647083,0.009775452,-0.018532883,0.0010602173,0.06347402,-0.02591059,0.001740073,-0.08524926,0.00070077553,0.017781049,-2.6552649e-33,-0.0077563147,-0.03898001,-0.04530874,-0.11355238,-0.028316893,0.051735036,0.023703165,0.043484904,0.03187579,0.01654051,0.035368796,-0.0050886106,0.057159282,-0.14337766,0.02164515,0.025758501,-0.035383295,0.06473814,0.027109146,-0.039000493,0.024009088,0.070712164,0.011013093,0.029458674,0.048423503,0.03939068,0.015659422,0.045664556,0.028785564,0.039660987,-0.038574897,-0.02732779,-0.056712504,-0.012201172,-0.029130662,0.050915252,0.026143843,-0.02699445,-0.04299314,-0.026762143,-0.020365912,0.0067425454,-0.006403804,0.06973175,0.07567339,0.055059593,0.01666374,0.030742181,-0.019143598,-0.059526376,0.0065281447,0.024841648,-0.018777978,0.105171174,-0.011747804,0.0026271103,-0.019048346,-0.010229922,-0.052694254,-0.022105591,0.0062763686,-0.012974761,-0.020829437,-0.07280164,0.051558286,-0.03726935,-0.069492124,-0.01896405,0.01157098,-0.009157154,0.08941032,-0.09266182,-0.09284747,0.049495902,-0.05529738,-0.08982736,-0.05987098,-0.047140617,0.043839272,-0.008534575,0.012958494,-0.009238984,0.034646884,-0.019757247,0.07833849,-0.010366586,-0.011639001,0.07081659,-0.008495966,0.034277383,0.018534746,0.009174601,-0.15311074,0.09224721,-0.085044004,-2.5283597e-08,0.0042929286,-0.045330707,0.08028169,0.0033495347,0.04089109,-0.035318956,0.0028192357,0.0078675,0.0022468115,-0.011712028,-0.06881355,0.06033843,0.06999338,-0.03829461,0.06030599,0.008425135,-0.0028518126,0.09647988,-0.02898303,-0.04144548,0.0058748033,-0.033982024,-0.06198301,-0.019708458,-0.03200615,-0.04435311,0.045286916,0.0656551,-0.002561766,-0.059866454,0.04647507,0.07010711,-0.010208426,-0.05992437,-0.05674324,0.07366683,-0.027977556,-0.028165745,-0.036830395,0.08298172,-0.06149875,-0.04643688,-0.054699868,0.07521846,0.07908368,0.0042260145,0.062452294,0.0036029723,-0.00067518186,-0.011116103,0.114359215,-0.009204142,0.0023393205,-0.027931156,-0.080604404,-0.013117728,-0.020685326,-0.008685281,0.0589682,-0.055771206,0.1060285,-0.02128406,0.13746372,0.017499102 +2.8.2.16,"Also acts on dithiols; substrates include glutathione, dithioerythritol and 2,3-bis(sulfanyl)propan-1-ol.",384,1.0,-0.06667724,-0.06863885,-0.02534061,-0.02018709,0.052206237,-0.016365932,0.027176416,-0.015629334,0.05280081,-0.0021002283,0.067308284,0.0034428427,-0.056772992,0.045953706,0.04451995,0.06265123,-0.0053400383,0.047516774,-0.019360568,-0.025362017,0.053641304,0.009047832,0.02007694,0.01012365,0.025060901,0.056360524,0.05977932,0.035373136,0.03286377,-0.06690314,0.03856397,-0.051993135,-0.020420298,0.0033552705,-0.038004164,0.06969194,-0.10545806,-0.045463797,-0.01938268,-0.04347645,0.06832959,-0.008132983,-0.015453152,-0.06449034,0.036957253,-0.058859028,-0.059887886,0.020334879,-0.0055191107,-0.026581334,-0.025995454,-0.017204808,0.036061354,0.108672015,0.05998029,-0.033200152,-0.050026402,0.058553386,-0.010699959,0.024629785,0.0043073203,0.016681498,-0.07702756,-0.06512715,-0.028347883,0.030461226,0.0042067897,-0.027956406,-0.008170487,-0.022061937,-0.043277215,-0.024566973,0.06456325,-0.029172696,0.062104087,0.022480953,-0.0067115347,-0.05405392,0.035728358,-0.075131565,0.010351773,-0.01708755,0.08882501,0.09649183,0.0041705244,0.030309087,-0.058464553,0.018996278,-0.009119684,-0.033614796,-0.021540282,0.014230781,-0.05881517,-0.04108186,-0.015216619,0.031405605,-0.059508845,0.045055367,0.011389639,0.03846943,-0.002617528,0.045175917,-0.09532264,-0.0523385,-0.15885054,-0.02650888,0.044443954,0.009211032,-0.039308187,0.020669805,-0.012969977,-0.009659161,0.043149855,0.016166372,-0.13770224,0.019132646,0.03871575,-0.015566035,-0.008361361,-0.07573037,-0.011851184,0.046850085,0.024317764,0.055389952,-0.06735555,0.043886747,-0.04762315,1.8610355e-33,0.11748112,0.016471844,0.038102057,-0.036449082,0.0079150535,-0.0065565347,-0.08738819,-0.046944812,-0.006977554,-0.11587599,-0.008348086,-0.029790863,-0.011155777,0.01812733,0.023232691,-0.06758867,-0.0013046467,0.06335246,0.09573811,-0.039824065,-0.011874947,0.024712084,-0.13140063,0.025796158,0.0027506412,-0.007550931,-0.044890337,0.09824887,-0.048987437,-0.005388696,0.042095777,-0.014462124,-0.02889173,-0.0020703853,0.012443906,0.028934991,-0.098177,-0.03584449,0.013572474,-0.03857484,0.028563945,0.02736804,-0.0028215256,0.042450342,-0.012008437,0.013692919,-0.07268043,0.06532082,0.049440783,0.081865884,0.0397601,-0.04204558,0.06804648,-0.09654041,-0.052415248,0.028409397,-0.0064677275,-0.09067599,0.10327493,0.040730923,-0.03190834,0.086050585,-0.08054124,-0.0047838446,0.0020465436,0.015075876,-0.054843295,-0.012108903,-0.049706608,0.0648465,-0.03934274,-0.005632842,0.008576079,0.053860135,0.016576461,0.018797576,-0.013243401,-0.02550032,-0.009842224,0.054968942,0.04124764,-0.035726618,-0.059164427,-0.042552806,-0.11621563,-0.01965191,-0.034555398,-0.09525925,0.05190282,0.03520635,0.040529005,-0.07145155,-0.06288873,-0.0054123756,-0.04312927,-2.9493484e-33,0.02717151,-0.032103647,0.04767512,-0.010094416,-0.051602118,0.03192229,0.009193935,-0.0841375,0.09925248,0.0025494038,0.0817405,0.026590614,-0.01434907,-0.012138797,-0.021780934,0.057353966,0.0015884715,0.075351395,0.012677191,0.0135878725,0.042417,0.13062848,0.04754415,0.0620605,0.03279168,-0.003878114,0.09071385,0.04704767,0.05469059,0.09307468,0.02023152,-0.015817253,-0.032393415,-0.07081795,0.0143740885,0.020929756,-0.035187073,-0.032950968,-0.051193923,-0.07758713,-0.022093583,0.013941332,0.051180772,0.15405956,0.007182584,0.043352436,-0.03619583,0.022474714,-0.070424266,-0.05267427,-0.017480515,0.03723672,0.016466787,-0.03286474,0.105284885,0.010947826,-0.0024599768,-0.07252637,-0.0469964,-0.056124687,-0.004719931,-0.03382201,-0.024163986,-0.036782514,0.00046632535,0.038873643,-0.007629849,-0.0002483109,0.10860024,-0.012844538,0.051952835,0.0035457867,0.068489894,-0.032455992,-0.10692199,-0.0022021302,-0.041153483,0.031879127,-0.049928047,0.0755663,0.07688436,0.05144806,-0.0199583,-0.080486596,-0.03387688,-0.032819197,-0.0144081805,0.12601115,-0.035991963,0.074678406,-0.07245808,0.039601006,0.004386823,0.08734583,-0.007986611,-3.357853e-08,0.0021761707,-0.07161203,0.09870666,-0.059746683,-0.11090231,0.02143547,0.12661488,0.010415543,-0.0008184331,0.022647643,0.008806019,0.1186622,0.0056793047,-0.023935426,0.06512166,0.025724547,0.016591538,0.031756017,-0.01853483,-0.05328469,-0.029703427,-0.010625416,-0.016653653,-0.00839179,0.015899668,-0.07583805,0.0037541362,-0.036452405,0.00621492,-0.010538225,0.08503951,-0.0016492389,-0.03531836,-0.07598705,-0.012544732,-0.010701645,-0.07412269,-0.015954923,0.0050659874,0.047351737,-0.015446189,0.035952553,-0.025739562,0.073844865,-0.059736036,0.0085795475,-0.023340117,0.042151276,-0.048251454,0.013490534,0.03313952,-0.03294816,0.01697051,-0.0344244,-0.14831689,-0.0014108754,0.017957067,0.0173737,0.009215263,-0.05735495,0.07245769,0.012221564,0.15178281,0.06868295 +2.8.2.17,The sulfation is at the 6-position of N-acetylgalactosamine residues of chondroitin. Not identical with EC 2.8.2.5 chondroitin 4-sulfotransferase.,384,1.0,-0.03315644,-0.10065586,-0.049070466,0.0062078577,-0.007038999,-0.0070292023,-0.039026093,0.08308652,0.038774062,-0.055183697,0.050840847,0.05742443,-0.03850934,0.015997894,-0.14479205,-0.0014464869,-0.05270588,-0.015860673,0.026472358,-0.008076505,0.060550705,-0.07066231,0.027275557,-0.014509063,0.023859119,0.02371163,-0.005752894,0.0033738837,-0.03701212,-0.06158463,0.004285057,0.00085252774,0.014603872,-0.034286246,0.04355491,-0.0026578829,0.020770362,-0.04414146,0.003059703,-0.034965288,0.05755893,-0.0018216685,-0.019490225,-0.0134952385,0.06534282,-0.11653531,-0.017046789,-0.00671879,0.06488862,0.015534662,0.021639971,-0.0014348773,-0.024482893,0.047287196,0.045587912,0.012036447,-0.08814706,-0.06217577,0.09934572,0.028170744,0.05664527,0.0496489,-0.007020262,-0.100491084,0.024925308,-0.06613762,0.1522224,-0.10670415,-0.03345611,0.07735716,-0.08817395,0.03345225,-0.0038481057,0.0351646,0.02330196,0.10219397,-0.07931604,-0.023078827,0.014069013,-0.07155267,0.011671358,0.01555661,-0.025081456,0.115256675,0.013662115,-0.061112653,0.028265946,-0.017163105,0.029308753,0.04211731,-0.028965764,-0.039603587,0.022133034,-0.032959882,-0.047347788,-0.029343592,0.0015319176,0.16932924,-0.0056359055,0.017913256,0.04953832,0.011968293,-0.06564332,-0.10352955,-0.024897838,0.010170846,0.019858671,0.07821487,0.05551558,0.017725363,-0.034492776,-0.03883274,0.024390556,-0.009981613,-0.04178186,0.13833888,-0.03491857,-0.04137424,-0.033526544,0.0655594,0.007043304,0.03393117,0.0069876206,0.046898197,0.012132674,0.0015281863,-0.060587037,3.0081936e-33,0.09755235,0.06841581,0.14458618,-0.007833185,-0.0746776,-0.04298517,-0.12603243,-0.004593325,0.015803969,-0.018005231,-0.014406292,0.015502594,0.042698227,-0.044422112,-0.06687758,0.03496821,0.02671698,-0.0037637388,0.017420737,-0.017510716,0.003942567,0.052349728,-0.07740983,-0.016322741,0.052858897,-0.046417397,-0.026454631,0.030405976,0.049604908,0.03957019,0.0058315382,-0.09624937,0.01869017,-0.025273917,0.035008956,-0.034514923,0.019287426,-0.04179218,0.036268506,0.037029594,0.08591993,-0.013490308,0.05987301,-0.013134086,0.023614667,-0.041793596,-0.02450134,0.022361273,0.057674933,0.060230553,-0.041976202,-0.053293116,0.08036745,0.017607084,-0.019083813,0.00664345,-0.0347404,-0.042500954,0.056402862,0.03253652,0.07800816,0.028112916,-0.06512296,-0.094453126,-0.04517794,0.023778683,-0.05353475,-0.010772923,-0.058252458,-0.035582326,-0.07858225,-0.041145865,0.053489264,0.09933453,0.053738844,-0.026263203,-0.022888765,0.10051684,-0.017941644,-0.0143854795,-0.1292049,0.010162411,-0.045419183,-0.031102411,-0.085599735,0.03899906,-0.0007886302,-0.018248092,-0.0019731154,0.04112517,-0.0523865,-0.06917622,-0.08666482,0.0117154475,-0.03519447,-3.5040947e-33,-0.011014944,-0.0077261827,0.0021729704,-0.047184657,-0.064110376,0.044611704,0.07883187,0.027656268,-0.00095818215,-0.028589742,0.1083364,-0.0120867165,0.029903019,-0.09399881,0.06792475,0.07256717,-0.033350226,0.0008551871,0.038414903,0.047879938,-0.049644846,0.058617402,0.015047593,0.091574036,0.039264742,0.036751475,0.08999229,-0.039319098,0.05861808,0.077572815,-0.064391054,-0.036040757,-0.08250994,-0.03264107,-0.097922884,-0.03774073,-0.0441598,-0.043929502,-0.03307072,0.012718017,-0.052038137,-0.009209817,0.04443992,0.08716878,0.052525397,0.028640756,0.015512526,0.053192306,0.010399015,-0.03742417,0.075947545,0.028178176,-0.01632713,0.062309295,0.024794128,0.109636046,0.013538576,0.06681168,0.030637905,0.0045197406,-0.028007993,0.044555217,0.012113734,-0.1162483,0.013118851,0.08253281,-0.06214745,0.003094544,0.014090857,-0.0839487,-0.025977664,-0.046892013,0.035327297,0.010796521,0.013386955,-0.01772485,-0.053176474,0.0033029004,-0.04628699,-0.043335527,-0.042534854,0.013935973,-0.00790535,-0.08884681,-0.0027589602,0.023233851,0.033642765,0.04798778,0.008093138,0.032631412,-0.015094286,-0.026895948,-0.09999165,0.010158676,-0.03928635,-3.151936e-08,0.05885908,-0.008877945,0.007177126,0.02623254,-0.023650128,0.0087427,-0.01692064,0.0033885464,0.0076215253,0.04662289,0.035111617,0.085381106,0.004078377,0.003682756,-0.017173244,0.06212473,0.0020113464,0.015245647,-0.030083023,0.009640345,-0.047652826,-0.0063114706,-0.049377233,0.023153935,0.030183304,-0.036633536,0.015260593,-0.018573172,-0.087841116,-0.06893666,0.08982547,0.020568727,-0.08280244,-0.07540665,0.022561371,0.030974515,-0.008404536,-0.025609452,0.036988284,0.0771408,0.003534882,-0.008674434,-0.054354593,0.0531119,0.034761988,-0.004859213,0.017306343,0.06405888,-0.037830956,0.027077785,-0.015655566,-0.045951806,-0.07480399,-0.106767096,-0.024274549,-0.039625064,0.06955971,-0.09354922,0.044126995,0.026136661,0.022510953,-0.055302918,0.1023738,0.029769292 +2.8.2.20,The tyrosine residues of some specific proteins of rat pheochromocytoma cells act as acceptors.,384,0.99999994,-0.061446864,-0.015372267,-0.09285654,-0.03434978,0.018279985,0.04896816,0.13771547,0.032550097,0.09066269,0.041154224,0.043948192,0.01598553,-0.14817043,0.043749154,0.0035976705,0.022577664,-0.09171803,0.030746654,-0.0064740144,-0.0063548656,0.001338085,-0.03561846,0.02651263,-0.0025571154,-0.020447023,-0.03349479,-0.0065663266,0.03197865,0.0027344562,0.039451674,-0.05822026,0.0006338827,-0.005804186,-0.0029459186,0.028878273,0.045968037,-0.06378314,-0.12934588,0.013493684,0.047494914,0.07052468,0.036478087,-0.025427822,0.047158875,-0.09282404,-0.017912729,0.0068026,0.025221469,0.1099993,0.01952695,-0.0054207044,-0.0072753998,-0.012508073,0.00062706124,-0.09231575,0.07290923,-0.082269914,0.025706856,0.06923781,0.028090602,-0.052650243,0.03385387,0.022696884,0.04108498,0.07219604,-0.02812365,-0.008714454,-0.033076096,0.015597696,-0.024476465,0.04479362,-0.010436186,0.03585961,-0.013269658,-0.019811722,0.0053360835,-0.01224816,0.029988972,-0.03523623,-0.015132856,-0.030565217,0.026157733,0.04996737,0.060024995,0.02269391,0.024436401,-0.07998119,0.09528712,-0.005757477,0.028568063,0.07740206,-0.028410222,0.061150633,-0.033024885,0.05368614,-0.005526047,0.053398546,0.031441912,-0.026030984,0.009415327,-0.014466641,0.017255802,-0.027762596,-0.012229879,0.054782663,0.03293877,-0.026514865,0.032016706,-0.06584865,-0.0029675001,-0.05859988,-0.07266845,0.08759263,0.033294078,0.046968408,0.0064396937,0.0032338444,-0.0234675,0.002504087,0.008541251,-0.0067003537,-0.029707693,0.031759985,0.070982344,-0.03316194,0.052990753,-0.035787486,3.4199791e-34,0.07860547,0.020133283,-0.009947126,-0.024722915,-0.05719079,0.028612152,0.040628377,-0.013180263,0.016567666,-0.003493538,-0.06461936,-0.06459373,0.017409174,0.025256233,-0.047809772,-0.0013986375,-0.031433854,0.023490869,0.092785224,0.048320584,-0.01743019,0.052224692,0.056979615,-0.027411485,-0.03272606,0.044008493,-0.19267906,0.069987215,0.057080947,0.018328018,0.0745706,-0.028922698,-0.01744651,0.0017794676,-0.028285155,-0.06635842,0.0019909928,-0.03776049,-0.008210824,-0.03152145,-0.068523005,-0.07138579,-0.09490413,0.04044851,0.037661735,-0.05903277,-0.026100358,-0.027808592,-0.04070827,-0.041498937,-0.012023486,-0.009502789,0.03606096,-0.023465563,-0.047366004,-0.08681371,-0.020028178,-0.044840652,-0.058999363,0.077668145,0.0070672873,0.021387061,0.03132349,0.05282616,0.03845421,-0.031621117,-0.034955014,-0.04292965,-0.10037461,0.024402441,0.036820404,-0.122929975,0.068998724,0.04570467,0.038514618,0.005677025,-0.025010744,0.011455827,-0.15269047,-0.014004938,-0.003325228,-0.06839408,-0.004510146,0.06148014,-0.05027827,0.032767143,0.09199127,-0.05385587,0.0010175072,-0.020608652,-0.0061134356,-0.06568243,-0.12825485,0.01720346,0.009198577,-2.3486105e-33,0.05832803,0.0070067416,-0.0601705,-0.08920652,-0.10740044,0.0699342,0.01790963,-0.031081071,0.03381615,0.052193012,0.052779295,-0.0014332194,-0.06102004,-0.112369075,-0.03569471,-0.062602915,-0.011292773,0.12118769,-0.062343158,-0.013591898,-0.029493883,-0.021221144,0.023741124,0.08704648,0.06116878,-0.015952937,-0.06050464,0.012161545,-0.070495285,0.015949037,-0.06226901,0.008163895,-0.038730673,-0.018358553,0.080530755,-0.03791159,-0.052062213,-0.08483895,0.02849595,0.015500442,0.07731563,-0.027239723,0.0006416576,0.014626513,0.023387613,0.054160338,-0.0135934865,0.06872393,-0.022953628,0.014306712,-0.10167971,0.008317201,0.026024682,-0.012439447,0.043125693,0.090659,0.024895675,-0.0030547117,0.0031461439,0.00714435,-0.0042079017,-0.025471224,0.007055276,0.015543913,0.088912316,-0.0057049603,0.03550789,0.11579496,0.08205704,0.0643513,0.033258907,0.02957103,0.07002511,0.07960295,-0.045342144,0.0051375744,-0.008982705,-0.053690463,0.06894175,-0.098645106,-0.03992217,0.008195977,0.039913375,-0.039365664,0.07258125,0.058600992,0.028425274,0.052331388,-0.016660346,0.0211165,0.1063584,-0.062479626,-0.019802434,0.050886687,0.02243271,-2.457041e-08,0.08458447,0.0030487876,-0.023236265,-0.09573552,-0.05429423,-0.045394097,0.0012963446,0.021789907,-0.026972836,0.028274188,0.018093916,0.01342081,0.03766858,-0.04186898,-0.029843729,0.07068732,-0.0334336,0.00059655047,0.00024107087,0.0092478795,0.004992329,-0.067107365,-0.0021638025,-0.002042929,-0.007183379,-0.07272452,0.0045480207,0.12741064,0.011505918,0.047181446,0.025407799,-0.12503846,-0.032671392,-0.0113453735,0.09921676,0.087277055,-0.021853888,-0.12593678,-0.03721979,-0.0038554315,-0.020354215,-0.0045786006,-0.0024573135,-0.03290444,-0.034539614,0.027937772,0.02093082,0.016767364,0.030113813,0.017209781,-0.021907397,0.016151607,-0.05208492,-0.004755858,-0.09318782,-0.079762146,-0.06167162,-0.008077154,0.0060101887,-0.044137217,0.0052476097,0.08799915,0.10115181,-0.07566778 +2.8.2.21,"Sulfation takes place at the 6-position of galactosyl and N-acetylglucosaminyl residues in keratan, a proteoglycan. Not identical with EC 2.8.2.5 (chondroitin 4-sulfotransferase), EC 2.8.2.6 (choline sulfotransferase) or EC 2.8.2.17 (chondroitin 6-sulfotransferase).",384,1.0,-0.024897026,-0.098387145,-0.074063286,-0.015146648,0.0034306291,-0.0045707873,-0.024834208,0.061242774,0.0520984,-0.059056725,0.08419053,0.092165366,-0.023817156,0.008417267,-0.14563668,-0.0024900255,-0.0570871,0.016560331,0.035923906,0.02792732,0.09795896,-0.02760231,-0.007140369,0.009812617,0.02391603,-0.01586273,0.011177497,-0.029625732,-0.055711113,-0.08285911,-0.004756684,-0.031411257,-0.002356827,-0.02040076,0.04634151,0.01608078,-0.024837976,-0.02723103,0.032213107,-0.035175104,0.016721185,-0.018005807,-0.030409208,-0.060754698,0.066871524,-0.08115437,-0.015548587,0.046614286,0.070050985,-4.8098544e-05,0.026810229,-0.06766989,-0.038180705,0.018921956,0.05973985,0.021556634,-0.0938868,-0.07402284,0.10330195,0.007662538,0.01065425,0.072301134,0.0074372366,-0.05840308,0.00993329,-0.076198936,0.11930798,-0.05518773,0.0013895134,0.06465387,-0.09800784,0.01479262,-0.0045563094,0.04422565,0.008374798,0.09231415,-0.08915455,-0.01790994,0.02280984,-0.08421476,0.061177243,0.03247784,0.007546561,0.060641,-0.031683356,-0.07323571,0.041790064,0.00934011,0.02739451,-0.0021840096,0.028427934,-0.031894457,0.012946029,-0.032960173,-0.07239462,-0.029726341,-0.0012301799,0.14853568,0.017724585,-0.018661952,0.023334153,-0.02626309,-0.022621587,-0.09634609,-0.019744227,0.024640234,-0.0054568322,0.07666803,0.04528903,0.031289797,-0.026237534,-0.063784145,0.020580424,-0.047429826,-0.019682385,0.12719046,-0.023426961,-0.031740915,-0.056493327,0.041048765,-0.006191206,0.048028164,0.05426371,0.016997563,-0.002895302,0.0641606,-0.033401098,3.4420917e-33,0.100480385,0.04231604,0.15076855,-0.010699108,-0.042456433,-0.080020264,-0.11859956,-0.03099652,0.0013181466,-0.044781968,-0.06356814,-0.03134475,0.01642873,-0.029768934,-0.049064398,0.084979355,0.021664336,-0.014131615,-0.0021422852,0.026451202,-0.02463849,0.04033222,-0.024634276,-0.05250874,0.06522011,-0.034641422,-0.013751234,0.011628003,0.0213279,0.017559838,0.01012263,-0.10530321,0.009798465,0.014231752,0.07197161,-0.0057137203,0.037270863,-0.038712338,0.016744189,0.041036163,0.058863897,-0.013495373,0.021277811,-0.019091893,0.0477328,0.0009026575,0.005763175,0.07885509,0.045465972,0.036350902,0.016034057,-0.03906147,0.04894962,0.01752362,-0.009615198,0.036446635,0.011072323,-0.0492977,0.05784452,0.07202673,0.062281094,0.035877522,-0.046428684,-0.104688175,-0.026353676,0.04100147,-0.08120827,0.022934973,-0.058365133,-0.027999474,-0.07640242,-0.0558014,0.091402344,0.12500778,0.031648625,-0.012863039,-0.01594457,0.05578048,-0.048715774,0.016924985,-0.11534272,0.02655321,-0.043368477,-0.022338463,-0.092896044,0.04008976,-0.058773525,-0.026749853,0.006626597,0.069567665,-0.06431306,-0.0050447937,-0.094998606,0.012629007,-0.03410184,-5.066807e-33,0.0571035,-0.022823092,0.018194407,-0.025382323,-0.060868986,0.08443985,0.04198903,0.021815386,0.061970495,-0.0010963521,0.023017626,0.00024278226,0.04086803,-0.091553785,0.06838218,0.075372264,-0.049008965,0.06850868,-0.041025873,0.0027795017,-0.019093236,0.047440775,-0.0301547,0.057359498,0.019582171,0.026670968,0.045584224,0.0024304448,0.039570488,0.047306847,-0.010326929,-0.0574534,-0.07838191,-0.08965953,-0.097042836,-0.009677234,-0.066517316,-0.024324834,-0.03335839,0.03118999,-0.0832787,0.017987335,0.0366506,0.07540593,0.07390631,0.015483177,0.017364247,0.03100627,0.052394968,-0.071304895,0.03086642,-0.0034874748,0.015800577,0.086731754,-0.0070193317,0.08113676,-0.0076115173,0.09713994,0.02623439,0.027745942,-0.034826506,-0.03283623,0.01329684,-0.1274814,0.0116238585,0.027631013,-0.026496135,-0.026615286,0.035623726,-0.061152283,-0.021597259,-0.07048548,-0.027633987,0.027009951,0.015939804,0.043332983,-0.06297619,-0.0051983315,-0.03975016,-0.010567896,-0.01648305,0.03682493,0.011570801,-0.07234382,0.022082286,0.04402824,0.041723963,0.042785138,0.0032841726,-0.013608216,-0.01442928,-0.011040083,-0.084485225,-0.002189621,-0.060910657,-4.1135642e-08,0.041086435,-0.019962708,0.038347673,-0.011115178,-0.013547051,0.006549803,0.029663162,0.038539995,-0.0024941699,-0.003955472,-0.0013179486,0.07853921,-0.0016621782,-0.02815364,-0.030219035,0.07001311,0.009851469,0.045142956,-0.054944597,0.004221253,-0.05047379,-0.032282017,-0.06338515,0.065849476,0.0038766868,-0.055405676,0.08257471,0.025301127,-0.1096964,-0.021606388,0.074501865,0.011184348,-0.09489068,-0.06666089,0.040168166,0.052462094,-0.037723016,-0.0034775927,0.043155637,0.069056526,-0.022660684,-0.029870111,-0.021378852,0.019273506,-0.007959186,0.017477805,0.018604461,0.05582897,-0.051668268,0.053136718,-0.010914878,-0.042794142,-0.08958531,-0.096391186,-0.035896543,-0.03308945,0.07038779,-0.095090166,0.02654959,-0.009748767,0.03663599,-0.07006079,0.15443803,0.036943402 +2.8.2.22,"The enzyme, characterized from bacteria that colonize the human and mouse intestine, catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. Activity is enhanced by Mg2+ and Mn2+ [1]. Unlike EC 2.8.2.9, tyrosine-ester sulfotransferase and EC 2.8.2.1, aryl sulfotransferase, the enzyme does not act on 3'-phosphoadenylyl sulfate or adenosine 3',5'-bisphosphate [1].The level of sulfation of polyphenols depends on the positions of the hydroxyl groups [3-5]. Hydroxy groups of tyrosine residues in peptides such as angiotensin can also act as acceptors [2]. The reaction proceeds according to a ping pong bi bi mechanism [6].",384,1.0,-0.022759577,-0.0928405,-0.026873356,-0.031582695,0.023857927,0.002563114,0.054823957,0.035084467,0.10948417,-0.020618161,-0.0031342956,0.07443832,-0.09392633,0.04749048,-0.011953326,0.09357546,-0.059809882,0.09325249,0.0057865204,-0.029587325,0.08935505,-0.07018302,-0.050482474,-0.024158686,-0.016168186,0.043087427,0.056702502,-0.025008494,-0.09507555,-0.019503655,-0.048240505,-0.037394848,0.05018385,-0.021184329,-0.018711759,0.09086389,-0.018777406,-0.08027095,-0.030262984,-0.042362522,0.0809826,-0.04769122,-0.04138624,-0.06965912,0.005731279,-0.10186015,0.012400215,-0.017633446,0.014696376,-0.024003014,-0.07885626,-0.00964952,0.0010766491,0.03168206,-0.03458612,0.057426788,-0.070739724,0.017835176,-0.0011838998,-0.056488916,-0.043805413,-0.019148227,0.0066652186,-0.031371593,-0.018412912,-0.02184627,0.024041113,-0.059353016,0.057883363,-0.046233036,-0.055197664,-0.008559924,-0.042250432,0.020510834,-0.02587278,0.06911865,0.01401802,0.0120425,0.028229337,-0.037509352,-0.013852668,0.006673726,0.00052804564,0.069446795,0.054012783,0.0164203,-0.011956593,0.07231739,0.010058969,0.097765416,0.03663065,0.0028521328,0.051056553,0.011863383,0.007269377,-0.0007443796,0.029402677,0.03893681,0.031106258,0.027795315,0.01305901,0.066833325,-0.044036567,-0.10831291,0.0073629357,0.050708935,0.022032198,0.055264898,0.031011436,0.030068714,-0.030509377,0.024122568,0.08439564,0.016128264,-0.06711092,0.114334166,0.025142046,-0.071768746,-0.03696458,0.011233844,-0.013167423,-0.03561178,0.023436451,0.052302558,0.009197047,0.08517821,-0.07444755,4.718802e-33,0.10124639,0.060166456,0.13802043,-0.0051778173,-0.06161289,0.0035533803,-0.07753126,0.061067507,0.058383577,-0.07331156,-0.13039222,-0.032795664,0.02092406,0.07314028,0.0240015,-0.02812751,-0.01814667,0.034865443,0.1617446,0.0108985575,-0.014089669,-0.017165752,-0.07911672,-0.032143626,-0.034939457,0.026893,-0.04263126,0.01067374,0.014087304,0.0127694355,0.0031047822,-0.1275814,-0.015731322,0.053889934,-0.03044358,-0.015892189,-0.00886836,-0.017517228,-0.0055869464,0.039790984,-0.0077850907,-0.032114908,0.027662463,-0.011766424,0.043292187,-0.09591652,-0.058125526,0.03582086,0.031648945,0.13297354,0.005993295,-0.039237287,0.06268941,0.0145862,-0.035016306,-0.022451188,-0.025516726,-0.026061064,0.0038802337,0.055350967,0.012144059,0.077097215,0.09209484,-0.044886302,0.003596447,0.03869995,-0.039915606,-0.052799735,-0.051022295,0.07148095,-0.052827694,-0.023372997,0.0017059791,0.02892421,0.021136329,-0.026939843,-0.038970817,0.028539384,0.04723816,0.020056428,-0.07867411,-0.040742427,0.031071257,0.05976547,-0.14842843,0.055191558,0.032470547,-0.067838505,-0.0057154186,0.01591752,-0.044912927,-0.057402965,-0.10681072,0.05847627,-0.004616666,-4.9061997e-33,0.070352845,-0.08147402,0.0129020875,-0.09091615,-0.10989953,-0.007272546,0.0357866,-0.032600693,0.04845933,-0.019557185,0.0450649,0.009963368,0.11977909,-0.061467577,-0.0341894,-0.005407861,0.033342723,0.041476123,-0.05607486,-0.016118899,-0.028825907,0.0782984,0.07067418,0.09120397,0.006395062,0.022947608,0.041853584,-0.030141706,0.007457112,0.089656055,0.05210983,0.05552827,-0.028170906,-0.015908351,0.039053667,0.021962732,-0.08121941,-0.031273738,0.051139902,0.023708278,-0.004667423,-0.028961975,0.04970398,0.07618984,0.026391994,0.0443979,-0.022740584,-0.009574798,-0.008512812,-0.05652021,0.0035772438,0.07133337,0.013169398,0.025626706,0.06366947,0.02617545,0.0007443286,-0.09208892,-0.056450468,-0.041047357,-0.06476012,-0.02522355,0.008641753,-0.06266294,-0.026179368,0.020574806,-0.05683947,0.010143705,-0.015901431,-0.048880592,0.07949303,-0.052688964,0.047053438,0.06785834,-0.0064394083,-0.05562587,0.01479385,0.015482968,-0.0028346886,-0.074710645,-0.05106245,0.029770479,-0.016124042,-0.12651461,-0.05556452,-0.049402263,-0.04992319,0.068768755,-0.020675177,0.032844745,-0.02513611,0.0139945615,-0.0952051,0.02650232,0.009872368,-5.2147076e-08,-0.0059973146,-0.025941627,0.02445964,0.03718187,-0.07891138,0.07884057,-0.026248207,0.019792385,0.037447594,0.050409842,-0.016064115,0.051099792,-0.01562836,0.028124848,0.028727772,0.033129353,-0.015699573,-0.019179245,-0.041361935,-0.07396237,-0.057618864,-0.017860495,-0.10752661,0.02839064,0.11124779,-0.07318122,-0.009624866,-0.01576511,-0.01468884,0.015429686,0.06327883,0.0037914854,-0.05105106,0.06475991,0.07909059,0.08881823,0.009099015,-0.0073594246,-0.021536559,0.03403733,-0.0725073,-0.03999219,-0.090533905,0.011325971,0.02009588,-0.0058003305,-0.006859213,0.07260089,-0.0066945595,0.024025496,0.09187102,-0.028941393,0.00075753353,-0.089039594,-0.07293326,0.018591816,-0.002833714,-0.07063601,0.053244263,-0.021387482,0.07752584,-0.0030272293,0.046809305,-0.021953719 +2.8.2.23,"This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases [EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2) and EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3)] by being the most selective for a precursor of the antithrombin-binding site. It has a minimal acceptor sequence of: -> GlcNAc6S-> GlcA-> GlcN2S*+/-6S-> IdoA2S-> GlcN2S-> , the asterisk marking the target (symbols as in {iupac/2carb/38::2-Carb-38}) using +/- to mean the presence or absence of a substituent, and > to separate a predominant structure from a minor one. Thus Glc(N2S > NAc) means a residue of glucosamine where the N carries a sulfo group mainly but occasionally an acetyl group. [1-4]. It can also modify other precursor sequences within heparan sulfate but this action does not create functional antithrombin-binding sites. These precursors are variants of the consensus sequence: -> Glc(N2S > NAc)+/-6S-> GlcA-> GlcN2S*+/-6S-> GlcA > IdoA+/-2S-> Glc(N2S/NAc)+/-6S-> [5]. If the heparan sulfate substrate lacks 2-O-sulfation of GlcA residues, then enzyme specificity is expanded to modify selected glucosamine residues preceded by IdoA as well as GlcA [6].",384,1.0,-0.106609754,-0.081225544,-0.1521651,-0.07324636,0.025047524,0.028653285,-0.012585475,0.056909554,0.06886894,-0.046247534,0.06435591,0.01488087,-0.008333867,0.036393184,-0.068067394,0.00358096,-0.018959591,-0.022167,-0.076355696,-0.0836593,0.057616398,0.051829427,-0.036810957,0.012102081,-0.0068477658,0.008444091,-0.045136437,-0.026201727,0.032401957,-0.012579887,-0.036584552,0.0038531132,0.05041036,0.0052646543,0.0751873,0.06373704,-0.05332073,-0.02647054,-0.012811176,-0.00045883638,-0.019498132,0.044266935,-0.02413439,-0.010387176,-0.0053358683,-0.06475213,-0.041778248,0.05696984,-0.011968956,0.019340895,-0.0074144173,-0.018600062,-0.051619284,0.07136335,0.04491489,0.020485641,-0.16537112,-0.047238268,0.003863986,0.040042393,-0.04057826,0.04707856,-0.012835759,-0.0328916,0.07093262,-0.003828519,0.13207121,-0.07707446,0.029509695,0.019247124,-0.055250727,-0.033151418,-0.031468358,0.064050384,0.06255278,-0.0025740555,-0.03687518,0.077335596,0.041162614,-0.086524256,0.023862436,0.080208376,0.023262948,0.10898832,-0.003648798,-0.057970405,-0.07799827,0.02591551,0.06979235,0.05879543,0.03328272,-0.055009264,-0.015363736,-0.03522019,0.025117865,0.006486365,0.042439725,0.09139509,0.0024469246,0.0025736003,0.056336902,0.042358,-0.03651929,-0.050513577,-0.034704726,0.0038616317,0.017644225,0.13093539,-0.015494318,0.019848943,-0.024450831,0.03682406,0.0073808064,-0.085742205,-0.10321599,0.124127366,0.050558332,-0.045193397,-0.037535865,0.030654864,-0.007333006,0.012606618,0.011894706,0.07708273,0.021357646,0.027885122,-0.07695687,4.612825e-33,0.07041983,0.041306578,0.034235448,-0.03546207,-0.06540514,-0.010028771,-0.08849674,0.03003624,0.0034943665,0.035312537,-0.025674429,0.0037986778,0.04190173,0.036224164,0.022130297,0.021301387,-0.008635067,-0.04647758,0.06470777,-0.013394225,0.005240554,0.07499116,-0.016562294,-0.05391251,-0.026612481,0.022053644,-0.046795018,0.043219395,-0.0077591296,0.007980215,0.057228852,-0.08112788,-0.014792217,0.028298995,0.052259903,-0.05460779,-0.051961437,-0.068567745,0.033749133,0.06444893,0.02252334,0.023735367,-0.029355064,-0.025546156,0.04213385,-0.09124746,-0.011505499,0.06568916,-0.011011264,0.07901328,0.0455226,0.003987157,0.084155045,0.017965905,-0.10261882,0.050841257,-0.00066045544,-0.037053056,0.026092043,0.06660017,0.008993483,-0.0032279156,-0.045757648,-0.01514355,-0.0127504645,-0.0016737779,-0.12598023,-0.017378572,0.039758246,0.0005393308,-0.048220348,-0.088776104,0.040983364,0.08054478,0.09551486,-0.04484742,-0.039807633,0.1065529,-0.004599616,-0.030400598,-0.05631927,0.021690665,-0.02635763,0.04158903,-0.14647794,-0.024554696,0.049892683,-0.11681276,-0.05843729,-0.0320355,-0.03381717,-0.041899733,-0.1035441,0.027773025,0.09807817,-7.0889414e-33,0.096038654,-0.059094112,0.022073215,-0.034688313,-0.015147884,-0.039007753,0.09982288,-0.08682962,0.04013258,0.005685505,0.110976964,0.051793925,0.020057296,-0.014190123,-0.0066203256,0.013990085,-0.04384038,0.05712368,-0.01601109,0.033161797,0.015606203,0.035607368,-0.0061419965,0.008502361,0.0070650615,0.017745972,0.015765177,0.015479145,0.041344564,0.073380835,-0.028063597,0.050021324,-0.04461388,-0.07005542,-0.008979236,-0.00846188,-0.01187026,-0.049184095,-0.06518197,-0.056249656,0.007961278,0.027514951,0.053345624,-0.004086596,0.0661142,0.117255,-0.010809212,0.054009493,-0.03787094,-0.037405923,0.030228322,0.07899389,-0.0034529457,0.089868434,0.046792768,0.04690203,0.024121162,-0.026824635,0.008836995,0.006407836,-0.0067503355,0.013126199,-0.038970206,-0.0690647,0.04043895,-0.032199048,0.0057520038,0.0017609365,0.06145081,-0.017016003,-0.040204413,-0.10634611,0.061569795,-0.027180256,-0.040234946,-0.06343514,-0.01979795,-0.025303477,-0.0060017197,-0.10146739,0.009260814,-0.050311234,0.014975995,-0.033215843,-0.0028346821,-0.026037954,0.02325512,0.09419958,-0.02268168,0.020780554,0.00043225108,-0.036817674,-0.07155631,0.027480341,-0.006765703,-5.556761e-08,0.020648342,-0.036575433,-0.018550742,-0.07003163,0.020857183,0.037884634,-0.07746325,0.03662902,0.022559658,0.05046706,0.073142685,0.05689704,-0.0754523,-0.050182197,-0.07308781,0.05184141,-0.039574992,-0.028251268,-0.040691752,-0.04256042,-0.08341268,-0.009532633,-0.06724717,-0.030554814,0.038445324,-0.12073099,-0.02865448,0.022120101,-0.011713436,-0.041884236,0.032090176,0.039824825,-0.0038081962,-0.09895225,-0.023893174,0.060249146,0.0042511425,-0.034668274,0.049187925,0.02449842,-0.010952269,0.0013366673,-0.058534965,0.019079238,0.07452275,-0.0071725375,0.02873864,0.0442623,-0.07135959,0.049738433,0.009233414,-0.04600388,-0.040742658,-0.073425695,-0.02358331,-0.06914299,-0.036711045,-0.06888618,0.070010565,0.014946528,0.015594036,-0.013869174,0.094929345,-0.014432082 +2.8.2.24,"This enzyme, characterized from cruciferous plants, catalyses the last step in the biosynthesis of tryptophan- and phenylalanine-derived glucosinolates. cf. EC 2.8.2.38, aliphatic desulfoglucosinolate sulfotransferase.",384,1.0,-0.057847302,0.0068177637,-0.13022622,-0.020928886,-0.013965816,0.065038815,-0.06611553,0.024385644,0.04337253,-0.022348005,0.061966088,-0.050425224,-0.09871688,0.002540123,-0.12847783,0.052125957,-0.0768071,0.028895477,-0.043837,-0.080385104,0.08126528,0.07023611,-0.055933334,0.014151734,0.053904813,0.00073331496,-0.017622974,-0.03029093,-0.032320224,-0.007507193,-0.033563744,-0.08056207,0.01101386,-0.040767375,0.06887145,0.056995053,-0.036944587,-0.018175108,0.07649781,-0.054872815,-0.021689503,-0.028907418,-0.05671349,-0.012235371,-0.033468116,-0.016518852,0.004948008,0.08328786,0.012441444,-0.07591257,-0.029672349,-0.0054832287,-0.05969291,0.012072701,0.09577506,0.011499945,-0.040046964,0.0017662614,0.03304718,0.0126842335,-0.0003899078,0.027792128,-0.028679853,-0.02984499,-0.04872699,-0.07879528,0.012111914,-0.09490846,0.06387947,-0.011881081,-0.07571762,-0.06385249,-0.048023187,0.03113203,-0.01998907,0.055421676,-0.060544387,-0.029765813,0.021019679,-0.008989795,0.10644212,0.03846719,0.048394416,0.075654335,0.03321183,-0.03301113,-0.05639951,0.07135581,0.08673697,-0.036333892,0.061121047,-0.06849472,-0.037595607,0.01609561,-0.03220536,0.05833525,0.0076900236,-0.010276832,0.031671863,-0.016448112,0.008626502,0.0014638079,0.0048090303,-0.16128397,-0.055562675,0.033203848,0.009552601,0.12823443,0.027149256,-0.020108962,-0.03052747,-0.0051099905,0.0015527708,0.0026608878,-0.017411921,0.14355886,0.033468697,-0.06541695,-0.07748836,-0.013244702,0.011940742,0.02883525,0.0019545732,0.08426319,-0.016748343,0.010952575,-0.083769515,2.9749398e-33,0.12426909,0.046325397,0.061437022,-0.0010014744,-0.038970906,-0.024957467,-0.05983514,0.015047703,-0.0030669875,-0.010389071,-0.1027552,-0.118593246,-0.028155321,0.024332765,-0.018103626,0.020655042,-0.06354941,-0.020581106,0.0731731,0.0040368126,-0.04166827,0.045932125,-0.05044778,-0.06812433,0.0050334507,0.049380694,0.0035405578,0.005578919,0.043125104,-0.02056468,0.04356302,-0.12744455,-0.078057885,0.0077976007,0.025262795,-0.016478574,-0.056660283,-0.02322309,-0.010617551,0.06924156,-0.023266774,0.06398111,0.032031175,-0.053775188,0.06172042,0.028390903,-0.008284682,0.085942894,0.06976597,0.11338316,0.010810497,0.008491381,0.059108067,0.038798567,-0.060232762,0.016068676,0.026229199,0.005784949,0.050859947,0.048684083,-0.018254926,0.016866302,-0.046965748,-0.033651337,-0.01459826,-0.021489045,-0.07209586,0.013595633,-0.016628971,0.081161104,-0.045165025,-0.102573566,0.037733827,-0.0036502487,0.025761709,-0.05634032,0.0077568386,0.032331537,0.010685792,0.029230563,0.027732084,0.0025958596,-0.060902625,-0.016166462,-0.10278304,0.0037941947,-0.06663789,-0.067350954,-0.024884146,0.0698094,-0.082155466,-0.012729571,-0.074881494,0.087225854,0.026555683,-4.389944e-33,0.110128626,-0.0835964,0.057852257,-0.087699145,-0.046253175,0.02513209,-0.013370212,-0.042244114,0.03974871,0.0025499428,0.05733165,0.00036608076,0.1076312,0.018694924,0.040642034,0.011561781,0.022452362,0.07833954,0.027949559,0.024957694,0.0372924,0.11430413,-0.077527106,-0.021791147,0.06424015,0.0027437224,0.013781641,0.06200685,0.07834529,0.052757084,0.009089629,-0.06264237,-0.05649883,0.0033334075,-0.020973751,0.049654134,-0.040693153,0.051443234,-0.004141264,0.04298238,-0.00016071506,0.03919754,0.058036357,0.06457615,0.07124066,0.049663078,-0.041440357,0.037737492,-0.02317496,-0.09760388,0.042263675,0.052685592,-0.011504162,0.032024194,0.06168417,0.050498273,0.026108416,0.008064546,-0.049387064,-0.048310615,-0.092323184,-0.058751788,0.026681596,-0.104911685,0.002731695,0.08208688,-0.025037782,-0.013144122,-0.012208474,0.025835305,0.031597286,-0.06874909,-0.005066406,0.04103468,-0.07393894,-0.087001644,-0.07313452,-0.018350903,-0.03809992,0.022988552,0.05718822,-0.024792818,0.058479812,-0.03284745,0.009075074,-0.09318098,-0.013117552,0.059146844,0.03349691,0.07242513,-0.019024562,0.021271203,-0.016647995,0.077976376,0.019743422,-3.3967503e-08,-0.027192267,-0.05798099,0.0183463,-0.011171206,-0.022611676,0.028900081,0.04592495,0.015424239,-0.041637506,-0.024682168,0.0045907316,0.07262419,0.0030656196,0.04784469,0.0046900427,0.034770943,-0.014844901,-0.017432988,0.03698983,-0.008861804,-0.058667906,-0.041307833,-0.07059598,-0.003019309,-0.017596235,-0.058647357,0.06668801,0.01051954,0.0118820155,-0.026036434,0.045410052,0.071273215,-0.0053369473,-0.04430863,-0.026084116,0.05647869,-0.07992964,-0.014970675,0.014116889,-0.01031804,0.0069184056,0.05310601,-0.01728395,0.0423812,0.00046591854,-0.02248973,-0.0017615022,0.029855458,-0.00791328,0.03890734,0.08386355,-0.05956408,-0.0062061287,-0.069851466,-0.067229435,0.005416821,0.020146709,-0.050986946,0.005272892,-0.024919806,0.04328458,0.021826304,0.16434845,-0.0025301364 +2.8.2.25,Also acts on some other flavonol aglycones.,384,1.0,-0.046041455,-0.17381574,-0.05501654,0.077867,0.04861617,0.0455807,0.054238513,-0.0026703633,0.033331107,-0.09183618,0.013106979,0.037321284,-0.12524793,-0.02458237,-0.058954485,-0.02887157,0.063355476,0.06776705,-0.09913305,-0.00610524,-0.012267305,-0.06877517,0.106087096,-0.040785994,0.00095792714,0.0048480188,-0.061961003,-0.0028702493,0.053636342,-0.07651373,0.06465306,0.06778007,0.04459495,0.0061552417,-0.07501108,0.010065583,-0.007820447,-0.021327654,0.05535812,-0.032193866,0.12188639,-0.002985597,0.04934527,-0.06658151,0.013614909,-0.0669692,-0.094856836,0.0037710725,0.043534677,0.04134872,-0.020158887,-0.045047477,-0.044672705,-0.013468998,-0.040060136,0.0099226255,-0.0261866,-0.012082623,0.01992182,0.06636255,0.01932879,-0.017666986,-0.034832958,0.018928763,-0.066438995,-0.010546826,-0.015096192,0.03328868,-0.011390456,0.025010798,0.05774577,-0.036704868,0.022809323,0.08756175,0.012345429,0.05911816,-0.031222047,-0.020707332,-0.012163165,-0.034960765,-0.0032915857,0.029808441,0.03797797,0.025642278,-0.015917467,-0.035060246,-0.02758228,-0.024056995,0.0019082378,0.08258696,-0.0012207308,0.015366962,-0.009642271,0.0050986973,-0.0204849,0.0083721215,0.060221642,-0.036228236,-0.08217829,0.03034918,-0.016258916,-0.03832663,0.012302116,-0.0549479,-0.065415666,0.0024792678,-0.036649138,-0.067818366,0.031113656,-0.017957948,-0.051574387,-0.01383667,-0.014400945,-0.07523966,-0.030749284,0.0196859,0.03415059,-0.027597247,-0.054085366,-0.077415355,-0.01577664,-0.0036778336,0.059730913,0.06594851,0.018928228,-0.04759183,-0.058265645,1.5481068e-33,0.063728794,-0.0151255755,-0.010110818,0.010164111,0.10175989,-0.00021737159,-0.024309536,-0.023748562,0.052578215,0.008565472,-0.07240404,-0.004818704,-0.03444249,-0.0064587686,-0.003514941,0.031180782,0.009144336,-0.0816509,0.016930006,-0.05161406,0.04580631,0.06891481,-0.064595066,0.033246852,-0.047839724,-0.01961796,-0.0061920388,0.029526632,-0.0077246786,0.025215462,0.030940358,-0.025148008,-0.014695066,0.057445787,-0.009965727,0.10901815,-0.059227597,-0.08821545,-0.042936794,0.034983847,0.03778098,0.013213234,-0.059723496,0.06122708,-0.05741544,0.010269412,-0.056953922,0.09227823,0.0816454,0.05608485,0.031587794,-0.0494554,0.1377362,0.082440935,-0.00047781022,0.10498653,-0.031819623,0.016825732,0.05937914,0.04255442,0.025606718,0.046964552,-0.004650545,-0.019186532,-0.07542631,0.06655894,-0.09276857,-0.009003577,-0.015506997,0.027003663,0.010453633,0.013332138,0.065053225,0.0069521843,0.04759995,-0.0616557,0.019282073,-0.032251135,0.0013577164,0.069717325,0.021236658,-0.043523427,0.057819515,0.033067655,-0.090028524,0.05107791,-0.035473414,-0.051231585,0.023409296,0.037257563,0.05272387,-0.049198635,0.01921126,-0.01345207,-0.063176945,-2.317538e-33,0.014722575,-0.06938035,0.060372338,0.09947218,-0.007601036,-0.019029448,-0.0342455,-0.0027976467,0.004454384,0.039342713,0.009418124,-0.057978228,0.02560099,-0.02118602,0.0048568435,0.052236434,0.051454205,0.14296201,-0.0253774,-0.0068944125,-0.17369235,0.055784374,0.04693398,0.07038018,0.010646703,0.02256452,0.02447365,-0.047296807,-0.09739367,0.022830863,0.037411425,0.026843358,-0.14012906,-0.13241373,-0.04181252,0.026628556,-0.03450769,-0.051025674,-0.08545645,-0.026997866,-0.0026092425,0.0025005753,0.0660826,0.08220459,0.06348117,0.01823171,-0.032984603,0.0021995397,-0.081071295,-0.014362722,-0.0450553,0.02349639,-0.007771379,0.10255087,0.042696558,0.02314027,0.0683267,-0.033926655,-0.08084125,-0.043394793,0.015464389,-0.050479356,-0.03407831,-0.01908292,0.15863721,0.049855515,-0.03704061,0.087430924,0.066575184,0.041128173,0.10397413,-0.087881945,-0.05654726,0.046734873,-0.034225363,0.0018174442,-0.012472765,-0.03401626,-0.022658994,-0.053029288,0.0047800667,-0.05172239,-0.029297616,-0.026507555,-0.10091255,0.0068382085,-0.007584461,0.062193174,-0.00929671,0.09521961,-0.042707708,-0.021373875,0.013969543,0.037433803,0.044762023,-2.104993e-08,0.0054107383,-0.016909806,0.010783058,0.04702652,0.0127881,0.021782912,0.0053386292,0.011374421,-0.016198386,0.0144163575,-0.08484482,0.08773459,0.049844213,-0.01929887,0.063763775,-0.043894164,0.048938055,0.04660886,-0.048242394,0.033168048,-0.12789539,0.031060155,0.0034867518,-0.019651925,-0.07393909,-0.070239514,0.009153629,0.032112375,0.091334336,0.021741336,0.042446796,-0.030280422,-0.021698637,-0.05011097,-0.049017493,0.032968853,-0.00029718547,-0.068952344,0.004297017,-0.0019135905,-0.07428073,0.013158603,0.006219292,0.06881929,-0.05917082,-0.0009799919,0.0064181862,0.035847124,0.03386601,-0.005787531,0.028876197,0.04383949,-0.04587274,0.002872549,-0.052021697,-0.024623832,0.02058206,0.02063433,0.075100474,-0.034564786,-0.025791597,-0.032080885,0.095379956,0.023977527 +2.8.2.28,"Quercetin 3,4'-bissulfate can also act as acceptor.",384,0.99999994,-0.053863037,-0.02410863,-0.07473864,0.034536928,-0.07479856,-0.057143,0.10601065,0.051366117,0.066587314,-0.07198286,0.0635235,-0.0384583,-0.04875697,0.06273121,-0.01224545,-0.012197015,0.014546084,0.074964605,-0.03003763,0.021487553,-0.027179884,-0.06965152,0.09371661,0.0463965,-0.066853344,-0.07388864,-0.00041268292,0.0009404912,0.00017034306,-0.096350625,-0.016298046,-0.018647313,0.017393885,0.045816272,-0.0593757,0.0033078978,-0.011238492,0.0012419898,-0.008434558,-0.008722254,0.0312576,-0.02053442,0.016861336,0.008405894,-0.027507521,-0.032495286,-0.05113063,0.051441766,0.0032796883,-0.063719705,-0.07666655,-0.017176209,-0.037010286,0.09088735,-0.023518968,0.014236669,-0.102041386,0.034023665,0.041193902,0.0445053,0.062765256,0.02152261,-0.021657497,0.023824664,-0.053719375,-0.023646299,-0.008871304,-0.046695523,-0.0054154843,0.022502044,0.0061640227,0.008968971,-0.029561382,-0.025066728,0.07450428,0.091070436,-0.026971439,0.013134985,0.0012585166,0.0037853462,-0.06359565,-0.034187835,-0.0059594014,0.0562757,0.053905405,0.00450562,-0.03850234,0.018361082,-0.025650207,0.039705884,0.05694553,0.024497412,-0.042881995,-0.04316835,-0.021175928,-0.031329177,0.038869537,-0.026019085,-0.06965167,0.030321902,0.03239785,0.022310173,-0.03104515,0.030574178,-0.017389435,0.031324122,0.03241985,-0.07736762,0.012857951,-0.08969361,-0.07861964,-0.14223205,0.06382507,-0.000844975,-0.05075001,0.05935684,-0.03514554,-0.08587712,0.036979023,-0.053121597,-0.045058556,0.085411705,-0.03093766,-0.045446075,0.0063535003,0.045858238,-0.024111314,3.167775e-33,-0.009626786,0.086847566,0.06078056,0.03797134,-0.04343797,-0.0037738997,-0.050971907,-0.010456882,-0.06498234,-0.014657378,-0.03640956,-0.10437625,0.0031566254,0.0819475,0.027952317,0.0092119165,0.010649654,0.057651777,0.016192732,-0.025333237,0.026010446,0.09292869,-0.11403261,-0.026057377,0.026256325,0.014154023,-0.010954192,0.063820966,0.035085373,0.010177122,0.015225989,-0.013874087,-0.03228247,0.06356725,-0.045571037,0.021949647,0.027579144,-0.055917956,-0.071461424,-0.030814646,-0.016616525,-0.015040908,0.007138665,0.010204722,0.009228122,-0.0457694,0.00811208,-0.025480608,0.06440244,-0.025516508,0.0333182,0.051612943,0.048456114,-0.052167904,0.01835735,-0.012799418,0.021822285,0.06795354,0.049341455,0.04608188,-0.03052916,0.048199207,-0.04687092,-0.027390491,-0.05047609,0.047509152,-0.058507834,-0.09624051,0.030853678,0.07982697,-0.04560499,0.010480058,0.024500962,0.10000698,0.05857814,-0.027060328,-0.061628696,-0.030575745,-0.0010692589,0.025096957,-0.09243612,-0.07210877,0.015157763,0.12208298,-0.14225705,-0.05610686,0.110713296,-0.061159007,0.069081284,0.02830166,-0.0046811486,-0.056149725,-0.022550624,0.028311301,0.019450158,-2.7071716e-33,0.07816895,-0.026093313,0.029566407,0.010307116,-0.010588729,0.06406443,0.02175937,0.05166454,0.069416605,-0.07881546,0.09382896,-0.001564728,0.13988258,-0.042669654,0.041752808,0.07023239,-0.025098855,-0.06575074,0.019520642,0.025557423,-0.024332128,0.075036615,0.021468747,0.03272058,0.015543315,0.056409683,0.074637406,-0.038539894,-0.034854665,0.04614141,-0.09323622,-0.06479631,-0.026327126,-0.0025108524,-0.04799866,-0.032143913,-0.03745705,0.023732137,-0.040578615,-0.02270847,-0.006270581,-0.074893706,0.033719134,0.20806475,0.02732568,-0.031779185,0.07176807,0.045223027,0.008116102,0.003502202,-0.020651141,0.044743415,0.006951632,0.03235541,0.12622252,0.0065009,0.005647019,-0.13309868,0.0026762611,-0.032618746,-0.013740504,-0.053859387,0.059369195,-0.0375184,0.102928385,0.0374009,-0.13134909,0.047939863,0.031936165,-0.057307024,0.10076197,-0.103768386,0.035006233,0.10221551,0.04226688,-0.04367269,0.0014619373,0.02147408,0.031370297,0.049057003,-0.10019182,-0.007658688,0.04497747,-0.06650175,0.050432757,-0.053605452,-0.006136113,0.024309143,0.017410055,-0.0025428417,-0.025662266,0.014030506,-0.012270867,0.025792122,0.042476982,-2.684684e-08,0.012989231,-0.01668491,0.0078016436,-0.040124524,-0.08025589,0.012212212,-0.010790095,-0.036505945,-0.09713993,0.065358736,-0.030575044,0.07309675,0.065608695,0.010696275,0.058237962,-0.012920335,-0.0055415756,-0.0070170774,-0.06706942,-0.0824357,-0.09391179,-0.0173963,0.001894934,-0.08770178,-0.05953282,0.055217605,-0.05201566,-0.0041525858,0.015140715,0.022006221,0.059276152,-0.00576076,0.06351276,-0.011765172,0.028389128,0.062309437,-0.0798325,-0.00060799345,-0.005000273,0.064714104,0.048818722,-0.030813197,-0.019912275,0.02829786,-0.03540721,0.029223181,0.02598834,0.014800895,-0.0037240682,0.015852187,0.03857088,-0.03716449,0.072861925,-0.012936168,-0.013778973,-0.013853435,0.021737318,0.0098744,-0.02017,-0.01845009,0.02943165,-0.07073949,0.087613456,0.0549191 +2.8.2.29,"This enzyme sulfates the residues marked with an asterisk in sequences containing at least -> IdoA2S-> GlcN*-> or -> GlcA2S-> GlcN*-> (symbols as in {iupac/2carb/38::2-Carb-38}). Preference for GlcN2S vs. unmodified GlcN has not yet been established. Additional structural features are presumably required for substrate recognition, since the 3-O-sulfated residue is of low abundance, whereas the above IdoA-containing sequence is quite abundant. This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases by modifying selected glucosamine residues preceded by GlcA2S; EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1) prefers GlcA or IdoA, whereas EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3) prefers IdoA2S.",384,1.0,-0.10231595,-0.11512915,-0.15345685,-0.1032344,0.032356836,0.0122772055,-0.06588224,0.07230401,0.08815818,-0.074990846,0.06758341,0.019873338,-0.036988784,0.039204895,-0.058837555,-0.009320811,0.022168705,-0.037486825,-0.016844284,-0.11608396,0.093272485,0.025298525,-0.030057525,0.003911245,-0.025761396,0.012057459,-0.0064496077,-0.025296263,-0.014032211,-0.025387347,-0.029935744,-0.03764186,0.053068306,-0.041256275,0.076310776,0.04385943,-0.080424584,-0.07039869,-0.025440918,-0.04933139,-0.008284132,0.011125332,-0.018453551,-0.033080205,0.008898041,-0.098614424,-0.001254545,0.022005495,0.0013025585,0.013438882,0.029175377,-0.060547445,-0.029161625,0.05392934,0.05589137,-0.0034580396,-0.11954073,0.007286729,-0.038685735,0.06905418,-0.054096017,0.07743635,0.01220016,-0.05534494,0.029638723,0.03589,0.09796035,-0.1244275,-0.018571163,-0.008993189,-0.072431386,-0.018264502,0.016338537,0.07865152,0.049552437,0.016043935,-0.013747417,0.06715675,0.04169846,-0.1059339,0.036250845,0.035586298,0.025704341,0.07995215,-0.013219325,-0.042860597,-0.065692864,0.026687704,0.052468736,0.060293507,0.06972597,-0.0095973,-0.048385426,-0.04287103,0.06573342,0.05187795,0.014095607,0.13153587,0.006361208,-0.024715552,0.011849375,0.032893382,-0.02405554,-0.05618425,-0.060495876,0.040827364,-0.0057460256,0.12295202,0.051690392,-0.008040696,-0.01766088,0.06391999,-0.015185072,-0.062372725,-0.11076434,0.1331907,0.025894357,-0.0357248,-0.04589084,0.022000676,-0.0190178,-0.013883615,0.05675839,0.060846794,0.023178281,0.051020935,-0.0795046,6.967725e-33,0.0696235,0.06338388,0.05299199,-0.06826292,-0.074357785,-0.031007085,-0.07845415,0.06230301,0.0100333635,0.00707642,-0.060164835,0.00016916821,0.0020645452,0.01573345,0.043793812,0.03938906,0.02514037,-0.038577918,0.041627187,-0.0402735,0.028917449,0.0348587,-0.0046170573,-0.04789266,0.053918436,0.0071022897,-0.011579444,0.003032837,-0.011102933,0.0022599555,0.0467789,-0.112100616,-0.026600696,0.01920866,0.054048996,-0.026339073,-0.0783918,-0.0616219,0.007245055,0.033605713,0.08006866,0.014845987,0.03348708,-0.016072465,0.032509346,-0.04839997,0.014531636,0.063801795,-0.013978879,0.059921995,0.07582191,0.034357402,0.069124304,0.050090276,-0.030725455,0.049181607,0.020683546,-0.04320622,0.045357354,0.030733235,0.007171054,0.013278035,-0.032758586,-0.015749713,-0.004138354,0.04140729,-0.15324771,0.038284495,0.0084820045,0.053322483,-0.008662437,-0.07643322,-0.0009745975,0.06931609,0.07016011,-0.030033873,-0.01817356,0.0940702,0.019115923,-0.03607657,-0.05068965,0.034276072,-0.010654681,0.038015883,-0.13857545,0.02387501,0.0621979,-0.08102191,-0.04188798,0.022627134,-0.03654652,-0.0085662585,-0.06294931,0.019521063,0.0372487,-8.676366e-33,0.07150809,-0.070046745,0.008173161,-0.061396133,-0.024752386,-0.042077605,0.109095104,-0.054166034,0.029391708,-0.04795875,0.053999674,0.05125447,0.00803534,-0.04889864,0.010434027,0.051378597,-0.08620396,0.07422627,0.018954748,0.011027623,0.04508523,0.040091116,0.032727946,-0.0028162475,0.0072797453,-0.0084821405,0.05335229,0.021217884,0.064028025,0.09549777,-0.03013437,0.054364208,-0.017048888,-0.036222927,-0.02058427,-0.00023517506,-0.038258083,-0.09573506,-0.025087629,-0.000647949,-0.030294403,0.05047721,0.01264473,0.025868515,0.040401276,0.12791766,-0.009746084,0.04777506,-0.03298662,-0.045898702,0.035300594,0.022923088,-0.01747956,0.058807995,0.045172285,0.053526714,0.01968285,-0.0021536627,-0.027192803,-0.022870978,-0.0099397935,0.012285066,-0.04328197,-0.054314926,0.014008267,-0.028389199,0.006902858,-0.045732193,0.014393935,-0.017764118,-0.06438745,-0.14045642,-0.020220885,-0.008329175,-0.035699356,-0.04183011,-0.03968694,0.024859745,-0.0021122068,-0.0730725,0.011774776,-0.03668246,0.018841024,-0.010501605,0.0048652547,-0.0013050057,0.015409907,0.10194062,0.023960544,0.06223758,-0.027715942,0.038173974,-0.063294776,0.04256387,0.00066497026,-5.6882783e-08,0.008612442,-0.028993273,0.049290672,-0.050672565,0.010282935,0.032171704,-0.05900733,0.05143194,0.0054174764,0.007446568,0.009808637,0.020822644,-0.096951105,-0.044360016,-0.045242056,0.010190028,-0.036657855,-0.03767637,-0.03194839,0.018846227,-0.10020661,-0.008557951,-0.085574694,-0.02569683,0.020388715,-0.10995313,-0.030686593,0.020994855,-0.030459195,-0.008150726,0.00482704,0.048350204,0.011847956,-0.10645807,-0.010396841,0.023065051,-0.033884715,-0.06508546,0.040425815,0.010222573,0.016705777,-0.023292325,-0.040062673,0.019054672,0.07213309,-0.03795172,0.053043474,0.041954365,-0.04330784,0.05934332,0.02027551,-0.078481466,-0.04726504,-0.08472851,0.016532658,-0.059621643,-0.011075278,-0.073605195,0.07559371,-0.00078049046,0.047750507,-0.03611497,0.10515419,-0.02706732 +2.8.2.30,"Two major substrates contain the tetrasaccharides: -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN*-> and -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN6S*-> (symbols as in 2-Carb-38) with modification of the N-unsubstituted glucosamine residue (shown with an asterisk) [1,4]. Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells [2]. There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes [3]. The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site [in contrast to EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S [unlike EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2)].",384,1.0,-0.09175559,-0.11166174,-0.14281347,-0.06927344,-0.0026516912,0.038191393,-0.018899718,0.095496856,0.104679056,0.034012645,0.014585584,0.057058197,0.01816872,0.036057267,-0.071244314,-0.031981934,-0.03967932,-0.006994418,0.01417997,-0.08080315,0.08028762,0.04663783,-0.0012556328,-0.06444846,-0.04416142,0.0032422636,0.0016456952,0.054435857,0.004705253,-0.011619987,-0.037073515,-0.066222474,-0.013475151,-0.02758562,0.02796264,0.05342863,-0.0658199,-0.049597554,-0.02105198,-0.036302224,0.0019466036,0.014810645,-0.026789874,0.012382556,-0.0041003423,-0.09047286,-0.035972133,0.023240456,-0.036501754,0.01048554,0.030112816,-0.038939767,0.011523824,0.08476283,0.0121245105,-0.054537978,-0.12510271,0.025440205,0.01900459,0.02362802,-0.028706359,0.02552469,0.035369765,-0.08046319,0.016832048,-0.013474977,0.028173193,-0.066097274,-0.021513047,0.027669143,-0.07681844,0.06270751,-0.0029292866,0.07742535,0.036696486,0.072158545,0.034356285,0.06500018,-0.012725183,-0.036236946,0.012865593,-0.0072746975,0.071985275,0.12847506,-0.04056818,-0.07806701,-0.08571617,0.06306443,0.073950626,0.041802973,0.005722914,-0.04498595,-0.031844746,-0.023396954,0.03849365,-0.02841693,0.030641934,0.07933856,0.0035673787,-0.038422387,-0.030495718,-0.01645138,-0.008666737,-0.036958028,0.0054571563,0.07213365,-0.0084991595,0.08238716,0.07029003,-0.046150256,-0.023941,0.062282346,-0.009333143,-0.07644364,-0.09955659,0.09694114,-0.034613438,-0.09555511,-0.011990469,-0.05183414,0.00785434,0.016256575,0.05283164,0.048419695,-0.035749614,0.01679388,-0.01272183,4.449992e-33,0.051552385,0.11062083,0.042525705,-0.004730476,-0.026510775,0.022839606,0.016825438,0.0403757,0.04461934,-0.003204219,-0.088076256,-0.021998132,0.050420616,0.04758151,0.0040885005,0.047392022,-0.008919525,-0.051079903,0.06679666,-0.06558758,0.02941657,0.08232835,0.004557425,-0.04643734,0.061839484,-0.012880129,-0.0389548,-0.0010042808,0.00838538,-0.014844965,0.044717267,-0.040912632,-0.03324941,0.007469179,0.0715859,0.0016891727,-0.07441132,-0.011257596,0.042783324,0.018239198,0.13522553,-0.004581206,0.037434418,-0.014681191,0.049059667,-0.044610526,-0.0014097115,0.022784704,-0.08535182,0.07331002,0.07145802,0.03887704,0.048756443,-0.005130588,-0.11466957,0.05450424,0.018088069,-0.06641452,0.027490662,0.02382038,0.010398728,-0.0051706205,0.028001186,0.011881921,-0.018423218,-0.02647662,-0.051324,-0.047158472,-0.036533833,0.07857999,-0.058700737,-0.04157731,0.013762325,-0.0013028802,0.028835427,-0.02367193,-0.007900542,0.08596868,0.00595644,-0.024674164,-0.021098245,-0.0060411287,0.012452867,0.06430758,-0.14078954,0.0063450485,0.027103584,-0.08778084,-0.053028278,0.006169721,-0.017018994,-0.017021276,-0.09083248,0.013500296,0.010532569,-6.495271e-33,0.07593833,-0.056296024,0.067113526,-0.041027125,-0.0490279,0.0031564033,0.116289295,-0.029410565,0.036121715,-0.054950736,0.09375442,-0.0222819,0.016298149,-0.06093238,0.009090337,0.035800323,-0.038086098,0.12019093,-0.02307253,-0.014046855,0.011163613,0.06015466,-0.01844265,0.04386678,-0.018710257,-0.0028220175,0.08858714,-0.0062441984,0.016891101,0.09386497,0.007946673,0.011157063,-0.020711081,-0.04511522,0.027749054,0.016456334,-0.0071322336,-0.12538037,-0.011088389,-0.038218655,0.07092077,0.006077881,0.04065355,0.046729706,0.01055869,0.11776999,-0.022686312,0.085273236,-0.046704542,0.001419727,0.03872683,-0.018504364,-0.0499586,0.044801056,0.104384065,0.030851955,0.047049057,-0.06812216,-0.009690563,0.00028234164,-0.027936254,0.033775993,-0.0029493524,-0.074427456,0.029630976,-0.010927523,-0.033130914,-0.037684735,0.07241617,-0.053526875,-0.03437735,-0.06489195,0.020535829,-0.04954138,-0.016465956,-0.05194501,-0.060938895,0.010457268,-0.008464226,-0.0659623,0.004513208,-0.029562429,0.06903461,-0.061669745,0.0855858,0.037571102,0.001057664,0.13967532,0.029759353,0.036882266,-0.02532679,0.011080163,-0.013953514,0.026738752,-0.012077335,-5.905408e-08,0.07361138,-0.014230365,-0.005975236,-0.017326126,-0.081692874,0.036686435,-0.04946309,0.06377719,-0.010888921,0.055354986,0.05140872,0.033260476,-0.054048616,-0.018772298,-0.07021662,0.044025548,-0.114245236,-0.01591403,-0.015712885,-0.030309787,-0.13234615,-0.010844626,-0.054181963,0.019578647,0.1117241,-0.06103434,-0.046994418,-0.010449362,0.03183912,-0.075591125,0.01848585,-0.00032056627,-0.068495244,-0.09792307,-0.039500665,0.040193565,0.03969815,-0.026631719,0.064121395,0.00053664105,0.00012527528,0.025688453,-0.040018573,0.014259895,-0.018697346,-0.025344048,0.0046834555,0.049232055,-0.042389616,0.019410677,-0.04231863,-0.023741985,-0.031100279,-0.10216123,-0.062285423,-0.08934252,-0.025635552,-0.078273244,0.07588462,-0.025908194,0.023632783,-0.032398034,0.07486119,0.002272863 +2.8.2.31,"The enzyme from the lamprey Petromyzon marinus can also use the corresponding 3-ketone as a substrate. It is stereoselective (5alpha-cholane) and regioselective, exhibiting a preference for an hydroxy group at C-24. The enzyme is inactive when allocholic acid, which has a carboxy group at C-24, is used as a substrate.",384,1.0,-0.044221513,-0.10877462,-0.036621578,-0.06335495,-0.03446982,0.100006685,-0.050898194,-0.029028153,-0.013812329,0.0118675195,0.049409244,-0.07859867,-0.097514704,0.026217496,0.0076872883,0.06353327,-0.07337721,0.013698607,0.025726167,-0.0031618262,0.052412663,-0.048582796,0.0070956503,-0.050395716,-0.0362986,0.026414067,0.009434054,-0.019112475,0.04838598,-0.079219006,0.02496267,0.06117461,-0.0129850255,-0.08218001,-0.02112333,0.04494376,-0.09996417,-0.11682606,0.008995191,0.0745446,0.02963397,-0.0038175315,-0.08103969,-0.040471155,-0.036735035,-0.054544207,-0.016113093,-0.08471806,0.014967475,-0.07515611,-0.015363577,-0.09100389,-0.008387292,0.013303852,-0.028426507,0.044727936,-0.08263352,0.025385005,0.03132963,-0.011281221,0.08845741,0.06220022,0.033555966,0.004054265,0.013504726,-0.013773172,0.01624355,-0.08718294,0.021297107,-0.038081557,-0.07125587,-0.10333082,0.017167177,0.009425152,-0.029628353,0.044945814,0.021296572,-0.054688044,0.06267055,-0.037196428,-0.073794544,0.006226045,-0.008998705,0.10895348,0.12834446,0.027506473,0.013615772,0.031157067,-0.005565781,0.028686883,0.053781386,0.032907467,-0.05892178,-0.07140054,-0.069129065,0.01213464,0.056674913,0.03174436,0.061740935,0.015855264,0.04350702,0.0305455,-0.042320438,-0.03232896,-0.07994574,-0.034774408,0.018472658,0.0332992,-0.022720642,-0.0041032885,-0.07930403,0.005654959,-0.018964384,0.010918547,-0.02516688,0.08391313,0.024046458,-0.084026106,0.04019737,0.020006439,-0.0021982617,-0.0136628365,0.038404576,0.059241474,-0.03289487,0.088473834,-0.08995013,-5.915085e-34,0.058404464,-0.007629042,-0.0097470535,-0.12202897,0.059538294,-0.0022167505,-0.078691386,0.061169304,-0.046042945,-0.08315803,-0.052284658,0.01782395,0.060848515,0.073342495,-0.008771613,-0.007569023,-0.032844063,-0.005654247,0.09363357,-0.041302036,0.03583067,0.05186263,-0.018223504,0.012517513,-0.014047647,-0.05743817,-0.04454155,-0.001942176,-0.00023883196,0.04277276,-0.043972142,-0.14916614,-0.032183804,-0.0068840007,0.0032469057,0.059878297,-0.03721521,-0.04655738,-0.07169348,0.08812103,0.08370006,-0.049035393,0.043385383,0.010241343,0.017247938,-0.033449046,-0.06037075,0.042797893,0.023599494,-0.019570542,0.0533248,-0.039103203,0.05733614,-0.07008148,-0.0339599,0.1116749,-0.016442286,-0.011205293,0.016310396,0.00061071053,-0.022001233,0.011879222,0.013165856,0.014356812,0.05169785,0.028977985,-0.066796675,0.003877713,-0.050287113,-0.047493257,-0.016296554,0.0026621572,0.060509283,0.01246925,0.062752165,-0.0048328205,-0.06156,0.017312352,-0.027225733,0.007911587,-0.0030800158,0.009611843,-0.020884287,-0.008657801,-0.06389139,0.01725826,0.033236068,-0.020902015,0.002941218,0.03357271,0.0441125,-0.10416699,0.0013949419,-0.017897941,-0.021946896,-1.9943244e-33,0.04124433,-0.04845388,0.045887806,-0.07681796,0.013607121,0.10400007,0.09682401,-0.04478756,-0.0042442423,-0.0023556442,0.048228703,0.026697282,0.07733289,-0.060786445,-0.0392104,0.056381177,-0.07191041,0.047308832,0.011948197,-0.056179352,0.0065593063,0.058201686,-0.0027698951,0.114961214,0.045494564,0.018120876,-0.013221581,0.041087355,0.038402252,0.053722393,0.00728815,-0.020144727,0.023771519,-0.053122148,0.053072438,0.10090047,-0.046487518,-0.009690483,-0.050983865,0.043784946,-0.05659005,-0.030120023,0.011622545,0.051169228,-0.0071594794,0.11609752,-0.0042336597,-0.032989483,-0.005924976,-0.003620315,0.009432825,-0.0039542187,-0.021223636,0.03544991,0.0070120706,0.14116271,-0.015154294,0.026722379,-0.020245599,-0.008258154,-0.033489816,-0.047341473,0.05362366,0.010950707,0.062446564,0.047108322,-0.070856996,0.011379215,0.0044271788,-0.07328874,0.046167348,0.06410883,-0.0051935497,0.04400977,-0.019949025,-0.0067535336,0.015122944,-0.058274623,-0.033500783,-0.039749023,0.030515578,-0.0043598395,-0.045401204,-0.030446377,-0.039077166,-0.1267144,0.003317905,0.06291998,-0.00070835656,-0.034642,0.015883693,-0.015321223,-0.13491453,0.056789402,0.14546888,-4.24255e-08,0.04597544,-0.049175836,0.040279288,0.008448679,0.008927312,-0.009441268,0.037257608,-0.033315267,0.036567755,-0.03358521,-0.0019024636,0.024153674,0.008756948,0.007157212,0.04496769,0.064187005,-0.008487417,0.032336313,-0.028836811,-0.03472315,-0.043533027,-0.03225251,-0.033510134,-0.035134602,-0.004334997,0.0024022225,0.0060838126,0.06528718,-0.03279208,-0.025854165,0.020479588,0.053874347,-0.014632299,0.0418677,-0.021365404,0.031113798,-0.037632372,-0.086565964,-0.042748746,0.056438684,0.027050031,-0.056064554,-0.102286406,0.008817366,0.048183057,0.012940774,-0.040993888,0.049732607,0.029351322,0.075293995,0.0141878,-0.0113367,0.0030103056,-0.0148963025,-0.06844905,0.0053065387,-0.0049109035,-0.07533418,-0.050477386,-0.03502913,0.023172565,0.060538843,0.2696678,-0.025605012 +2.8.2.32,The enzyme from the shark Heterodontus portusjacksoni is able to sulfate the C27 bile salts 5beta-scymnol (the natural bile salt) and 5alpha-cyprinol (the carp bile salt). Enzyme activity is activated by Mg2+ but inhibited by the product 5beta-scymnol sulfate.,384,1.0,-0.07317283,-0.06294909,-0.029915255,-0.040155258,-0.042882405,0.011607923,-0.00053821225,0.01093124,-0.019658526,-0.013788533,0.07438765,-0.002268386,-0.08720621,0.08759892,-0.049379338,0.1011314,0.016671412,0.057068303,-0.015121435,0.017926883,0.09126278,0.008810426,-0.062438674,-0.029705543,-0.05864065,0.077559695,0.038980376,0.01739069,-0.0147073185,-0.018956792,-0.05631619,-0.016123392,0.07575054,-0.08893632,0.021255057,-0.012167142,-0.08354173,-0.08391682,0.015891679,0.0651792,0.04624144,0.033075884,0.0010495757,-0.016606,-0.0069301156,-0.09208653,-0.030271798,-0.0027896478,0.048995875,0.057692096,-0.070337966,-0.092101455,-0.004497551,-0.02231186,0.05681629,0.04093742,-0.13063158,-0.05664438,0.04236513,-0.060411103,0.0611569,0.06609144,-0.003554951,-0.03057311,0.016174495,-0.0023078998,0.021216804,-0.046900596,-0.0007369951,-0.030200344,-0.03201942,-0.04140392,0.008407741,0.02362777,-0.009870704,0.04298428,0.01928901,-0.06691587,0.054660276,-0.024101766,-0.058544785,-0.053883966,-0.012637135,0.12272466,0.08046004,0.05084812,0.005581748,0.03222346,-0.009715784,0.026897283,0.049717367,-0.05885791,-0.08671751,-0.12392006,-0.009731935,-0.031114114,-0.082422696,0.0077365567,-0.02818532,0.017558657,0.019967621,0.03732798,0.008946178,-0.17972513,0.013371429,0.039878797,0.023478622,0.057707183,-0.004914486,-0.018812645,-0.017552244,-0.01665684,0.017740237,-0.048115063,-0.0704026,0.17220774,-0.0065238024,-0.084561855,-0.04153788,0.020756004,0.03929922,-0.006059253,0.02222677,0.050471257,-0.037213054,0.07043287,-0.07345501,1.13383e-33,0.055259872,-0.044496555,0.014738492,-0.017492138,-0.005026427,-0.029284345,-0.010541485,0.014105375,0.021735877,-0.03409539,-0.06832876,0.060387075,0.024855498,0.00949432,0.03417547,0.06791526,0.05925239,-0.033011287,0.092650376,-0.03316995,0.09297162,0.04604636,0.004913846,-0.087598816,0.029371083,0.035587434,-0.016593356,-0.044748414,0.10644662,0.029891197,-0.007152925,-0.07113435,-0.039429583,0.035084117,0.07800543,0.094327375,0.022395082,-0.029004462,-0.042792667,0.030031327,0.03509832,-0.046138395,-0.036210347,0.023275843,0.0015767424,-0.10252953,-0.107754156,0.036362942,0.108960986,0.045553427,0.0724718,-0.014575835,-0.013855609,0.046945736,-0.07063221,0.06818534,0.019794859,0.028273843,-0.002465559,-0.00066777173,-0.055896513,0.047515936,-0.020938039,0.03602888,0.08414504,0.07717613,-0.015308049,-0.06042627,-0.048539203,-0.0051285266,-0.073645756,-0.059791654,0.0055337986,0.010567412,-0.08974883,0.00015447778,0.0072650863,0.030641418,-0.018581117,0.020075828,-0.03829335,0.00093799125,-0.0014613833,0.012840286,-0.10208218,0.039096825,0.005441657,-0.027528243,0.0063036685,0.011783131,0.015343536,-0.0240759,-0.07316964,-0.029692357,-0.0017257559,-4.0649355e-33,-0.014800696,-0.07138176,-0.0028080516,-0.036043305,-0.07234859,0.0696823,0.050163046,-0.059342004,-0.012064707,-0.032568324,-0.0033021478,0.0119295055,0.033739515,0.0028517777,0.013531408,0.0460829,-0.023839667,0.11998261,-0.015231539,-0.04896764,-0.028579215,0.10311243,0.09660541,0.12589578,0.05584363,0.030665865,0.05325036,-0.018341774,-0.0035976637,0.061370205,-0.007040093,0.06478232,-0.0038624823,-0.058474034,-0.056020778,0.032193292,-0.068697765,0.012235076,0.01670713,0.078775205,-0.029276846,-0.059788283,0.09859967,0.08450278,-0.010604669,0.078148566,-0.0071393107,-0.0188516,-0.014972344,-0.033895787,0.06457399,0.015184664,-0.013263825,-0.0039660647,0.05924218,0.050139878,0.019011658,-0.047759306,0.03120115,-0.046565875,-0.04460886,-0.041044295,-0.020115275,-0.084921576,0.047733806,0.04469095,0.017997505,-0.07036325,-0.03728468,-0.05110982,-0.0037184192,-0.0045129973,0.02568937,0.042556614,-0.02165229,0.00091116916,-0.071217306,0.022818463,0.03962174,-0.06747861,-0.012296553,0.021108625,0.022998912,-0.038682297,-0.000112587746,-0.07260063,-0.043124117,0.090106234,0.08301515,-0.0443967,-0.04671977,-0.012946754,-0.1103864,-0.02797606,0.022802597,-3.4283207e-08,0.076081276,-0.009258886,-0.029411724,0.06266984,-0.09435549,0.02689128,-0.053105205,-0.0069805956,0.038382914,0.013448808,-0.01162749,0.07252963,-0.02441329,-0.036141187,-0.005245706,0.036929645,-0.009139308,-0.008498317,-0.0073340465,-0.0703355,-0.045088172,-0.018930195,-0.04188764,0.028437685,-0.008157889,-0.11604647,0.048872307,0.053051904,-0.027631694,-0.013412779,0.016524438,0.013787958,-0.07616639,-0.0050845006,-0.0094432235,0.06397823,-0.0025111542,0.0009639956,-0.007191235,0.050898273,-0.06381003,-0.008134188,-0.09553811,-0.007268096,-0.07233406,-0.007612838,0.11799606,0.055187102,-0.005333795,-0.007032361,-0.073801816,0.008874787,0.038485926,-0.041903988,-0.06408111,0.061555795,0.0430467,-0.074590184,-0.064386755,-0.010078598,0.015856551,0.016160673,0.09088474,0.04454643 +2.8.2.33,"The enzyme is activated by divalent cations and reduced glutathione. The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate and dermatan sulfate. Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not. Differs from EC 2.8.2.17, chondroitin 6-sulfotransferase, in being able to use both chondroitin and dermatan as effective substrates",384,1.0,-0.03590516,-0.11289338,-0.060149547,0.006936104,0.008015598,0.02437196,-0.03847579,0.06543956,0.028022561,0.011019162,0.048795283,0.07365423,-0.05833424,0.014843721,-0.09181026,0.010427058,-0.015305123,0.012130681,0.036331765,-0.03720917,0.058403485,-0.071845226,-0.036707886,-0.023814108,-0.010454787,-0.04258953,0.018840708,-0.0148242405,-0.04149862,-0.042219847,-0.059101444,-0.06156953,-0.010545765,-0.01991474,-0.036689784,0.06594225,-0.006814067,-0.053253394,-0.00038313717,-0.04849662,0.034246147,-0.014092778,-0.014327588,-0.040003266,0.03309451,-0.13182782,0.0022687793,-0.005248662,0.05411139,0.006957164,0.0033767028,-0.027806677,0.005593132,0.028735839,0.06783976,-0.026407532,-0.081370324,-0.08852706,0.050568152,0.04403604,0.0013263011,0.027776396,-0.027268969,-0.09909938,0.029904142,-0.085933834,0.098332815,-0.04605572,-0.054023925,0.01839979,-0.062156584,0.032329403,-0.0049712374,0.0244021,0.04612738,0.05238985,-0.096314594,-0.005696779,0.0397292,-0.03712802,0.038077556,0.0012922649,-0.007497297,0.12736611,0.0009118688,-0.033356473,0.002920695,0.037046306,0.0372778,0.03549814,0.02528807,0.032503434,-0.0081378305,-0.058048762,-0.07790467,-0.05000718,-0.0733483,0.13336426,0.0007963203,-0.009035903,0.022693627,-0.023525868,-0.04655043,-0.07961382,-0.043701522,0.0254437,0.034445938,0.108363494,0.06762934,0.01757609,-0.022316173,-0.007986917,-0.013073788,-0.028438307,-0.11115282,0.17093405,0.013866291,-0.0908755,-0.05880018,0.039952517,0.014257316,0.062427357,0.074589305,0.0627501,-0.02268471,0.011208308,-0.005998511,6.1193896e-33,0.07202391,0.043925177,0.09909698,-0.017533593,-0.030737547,0.0027390744,-0.08900306,-0.0027492826,0.021418411,-0.041334238,-0.05450599,0.014226981,-0.008582281,0.04671182,0.015110153,0.06700835,0.07086686,-0.04673471,0.07090405,0.024915017,0.055781502,0.021206152,-0.054015987,0.0050922353,0.061400775,-0.0051676226,-0.061082155,0.053426553,0.04868252,-0.0018109169,0.09587495,-0.09174434,0.009757011,-0.03926981,0.052182887,-0.020398615,0.011794225,-0.0032886416,0.02595528,-0.021696396,0.08850426,-0.041816328,0.025352653,-0.014577553,0.037357956,-0.06069101,0.008018882,0.015057546,0.009374704,0.0855436,0.04140173,-0.023813855,0.038106997,-0.0136919515,-0.051251296,0.03532664,-0.019705644,-0.08305397,0.024611108,0.087377764,0.026098037,-0.0025558637,-0.044089805,-0.056278244,0.010576346,0.009494296,-0.05127129,-0.014203297,-0.07042953,0.026040114,-0.116344005,-0.052887045,-0.0049953437,0.09190489,0.007163739,-0.027190054,-0.04518217,0.07109151,-0.013342669,-0.06803343,-0.06949575,0.017700149,-0.033740934,0.004326762,-0.046827346,0.05826197,-0.05682983,-0.024123417,0.019336782,0.021263896,-0.0023381144,-0.057283156,-0.12662625,0.057521667,-0.04548585,-8.0543565e-33,0.030308003,-0.01663876,0.009268088,-0.059133165,-0.03572924,0.061654717,0.08126079,0.026380049,0.046473056,-0.035726316,0.027466608,-0.017909538,0.058910504,-0.056051962,0.019451484,0.042524833,-0.09754878,0.05148974,-0.022564333,-0.010892525,-0.0650183,0.09566173,0.08396201,0.035931252,0.070443965,0.017263532,0.06485749,0.03075913,0.039112706,0.12308387,-0.045126658,-0.05667771,-0.07195099,-0.06988658,-0.060431786,0.016371714,-0.062953755,-0.059367944,0.02423033,0.029348386,-0.019743053,0.016582126,0.018156132,0.028734399,4.590207e-06,0.07768671,-0.048132014,0.0666956,-0.018006038,-0.07226086,0.0946781,0.046131454,0.0023447624,0.031399388,0.05921283,0.04863801,0.059610046,-0.0027820573,0.034395717,-0.003056453,-0.028909178,-0.008653607,0.0009930466,-0.095959954,-0.002900438,0.051189933,-0.009411221,-0.012250655,-0.011844187,-0.07370197,-0.039915703,-0.033806313,0.026811253,0.0107795205,0.01029479,0.021902349,-0.08800761,-0.010271352,-0.025240423,-0.002263834,-0.037432875,-0.01938267,0.023863286,-0.09288131,0.038832687,-0.007184691,0.026441626,0.0858112,0.04481772,0.07121619,-0.019689111,-0.024095606,-0.049647894,-0.006756436,-0.04277783,-4.4136463e-08,0.03532718,-0.04207696,0.011875938,-0.027688507,-0.081500754,0.0088938875,0.0064265467,0.010877348,-0.010442318,0.0132536385,-0.01907336,0.12994348,-0.007625267,0.00064108934,-0.0315394,0.032486398,0.05248368,0.0550668,-0.030930985,-0.0035290127,-0.0876267,-0.009140231,-0.08307425,0.06521496,0.056203272,-0.067912064,0.022914,0.022738785,-0.07218156,-0.05022961,0.081236705,0.008058924,-0.06347863,-0.06318844,-0.03621409,0.061414212,-0.04054202,-0.009294073,0.04021294,0.01900691,0.008892857,0.012202841,-0.11301655,0.0071887043,-0.0080936905,0.021586005,0.030145599,0.07239121,-0.0606228,0.092342176,0.006413384,-0.079529636,-0.03380312,-0.078751765,-0.0436023,-0.07027605,0.028246783,-0.07830548,0.01356261,-0.041734066,0.010783184,-0.047749598,0.1642359,0.0057772603 +2.8.2.34,"The enzyme specifically sulfates glycochenodeoxycholate at the 7alpha-position (see also EC 2.8.2.14 bile-salt sulfotransferase). The monohydroxy bile acids glycolithocholate, chenodeoxycholate and ursodeoxycholate act as inhibitors.",384,0.99999994,0.007931703,-0.092183664,-0.06809976,-0.04527781,-0.051477805,0.06517631,-0.110087715,0.03808774,0.03403006,-0.011548549,0.024308337,0.05477924,-0.058351085,0.015939206,-0.08815761,0.04177228,-0.03705107,0.045361713,-0.0010772627,-0.03731618,0.05270292,-0.0014033349,-0.020569945,0.023371762,0.06620141,0.0222545,0.050679576,0.006397195,-0.011406567,-0.097926386,-0.035390817,-0.040352337,0.0649895,-0.0021277722,0.008046414,0.040443487,-0.031490937,-0.018550359,-0.010100382,0.032653127,0.0049159033,-0.0021041553,-0.059874617,-0.06748076,-0.053401478,-0.08094361,0.005830006,-0.008791994,0.0486543,0.002206106,-0.053020813,-0.10794623,-0.060469158,0.04474659,0.060460187,0.04814964,-0.06843256,-0.031525865,0.029372208,0.034073066,-0.005665542,0.048084874,0.059787683,-0.03097175,-0.012801949,-0.0007514253,0.08334101,-0.080670364,-0.0084352745,-0.08507461,-0.06802519,-0.056620855,-0.035978995,0.006013176,-0.016475562,0.049751893,-0.056507897,-0.047789797,0.06677232,-0.0731667,0.009802595,-0.008236419,0.026001602,0.11948045,0.0276615,-0.06528245,0.032209415,0.035172213,0.03459617,-0.019033577,0.058842946,-0.038572837,-0.0445328,-0.0328411,0.02503265,0.0024111639,0.015716074,0.09214523,-0.0074093137,-0.029193148,0.07716617,0.04978013,-0.028521005,-0.1020419,0.0041318615,0.019856045,0.029054672,0.06242686,-0.005586588,-0.06184682,0.0019646545,0.008113486,0.043660756,-0.032309018,-0.09531672,0.084475905,0.050846677,-0.047873925,-0.07089234,0.04648858,0.0087144375,0.015523716,0.029852549,0.07237855,-0.023767881,0.059495527,-0.06017426,4.2801347e-33,0.102125406,0.046986207,0.07612208,-0.02215739,-0.03515972,-0.020126183,-0.037912633,0.072219685,-0.011194905,-0.05597953,0.0044690105,0.030069062,-0.002516932,0.03214715,-0.034038067,0.049888175,0.03821317,-0.032770775,0.029737309,-0.026597291,0.05220946,0.0035267833,-0.068192154,-0.011830441,0.02965978,0.036307342,-0.062457193,0.05406754,0.03624505,0.005609691,-0.01023182,-0.11520306,-0.06568285,0.052003667,0.06336237,0.012962247,-0.05249017,-0.020788165,0.0022757335,0.071107544,0.0032223717,-0.04799781,-0.00952598,-0.06289209,0.031118955,-0.025268635,-0.0807609,0.060363416,0.07141815,0.10564744,0.05986309,-0.025285175,0.012870685,0.013187612,-0.02337264,0.0040991986,-0.0047861226,-0.03138162,-0.013130026,0.04576938,0.032144118,0.047529258,-0.04960172,-0.03600976,0.03931929,0.0117214555,-0.07160377,-0.016859094,-0.089507595,0.012125805,-0.06391085,-0.034917876,0.0735535,0.05111052,-0.049482934,-0.044711098,-0.00866538,-0.014589526,-0.0020689913,-0.024769073,-0.037857953,-0.02571224,-0.031948563,-0.03601146,-0.14543067,0.011200622,-0.022129135,-0.09206194,-0.07478761,-0.0012335764,-0.06342274,0.005028794,-0.10921502,0.03975763,-0.018737465,-7.023029e-33,0.10066322,-0.104997605,0.035908017,-0.08133204,-0.040730488,0.08258198,0.08156525,-0.023332221,0.0704325,0.020497875,0.04815128,0.003937552,0.08645524,-0.058037072,-0.002289204,0.05485907,0.024338763,0.037368108,-0.005457936,0.00054818456,-0.012640505,0.13229431,-0.00541954,0.10531789,0.07002394,1.6418662e-05,0.051551033,-0.009296274,0.03812027,0.0949727,-0.0006173974,-0.00037065143,-0.049133305,-0.04979749,-0.09120394,0.03678903,-0.11519055,-0.05029922,-0.038797647,-0.02342997,-0.050202303,-0.032882683,0.07951708,0.030846763,0.051407922,0.056515507,-0.015916305,-0.0027709878,0.024268849,-0.055143062,0.048817992,0.057494134,-0.0037570857,0.12018686,0.018665936,0.10051106,-0.056545544,-0.025501,0.038822085,-0.06910443,-0.050049856,-0.01707111,-0.008650072,-0.046864223,-0.05194405,0.04602946,-0.061619177,-0.054067813,0.018838312,-0.07444501,0.017725967,-0.054624084,0.027400883,0.048627034,-0.04718012,-0.014493819,-0.031318467,0.01094773,-0.029378273,-0.071007185,0.053103335,0.029142363,0.00796839,-0.039621413,0.015611868,-0.04218562,-0.039244384,0.11133933,0.039713982,0.018196432,-0.011001009,0.013774505,-0.11876103,-0.011046828,0.01567281,-4.0933116e-08,0.045382086,-0.06767703,0.06451425,-0.024282495,-0.010755557,0.017750412,0.059127968,0.020783463,-0.026636617,0.03338739,-0.012688794,0.08824673,-0.004378169,-0.045536876,-0.001108973,0.08660942,-0.043936178,0.05429369,-0.0062452964,-0.007723395,-0.06933334,-0.025508473,-0.07068902,0.07058072,0.046157047,-0.031458803,0.005051519,0.010357119,-0.06650427,0.013678182,0.08339523,0.021772208,-0.013953418,-0.08120761,-0.014002316,0.08295963,0.006615501,0.009605175,0.0022002105,0.018019043,-0.039844282,-0.0231558,-0.04722032,0.01790417,0.017295105,-0.017089367,0.008976472,0.065832965,0.038606457,0.05830432,0.02099823,0.0006449468,-0.035069205,-0.05979726,-0.038331874,0.033870198,0.055411693,-0.12347175,-0.068090364,-0.019902064,0.0369079,-0.023428878,0.18121545,-0.0038545704 +2.8.3.1,Butanoate and lactate can also act as acceptors.,384,1.0,-0.040578887,-0.069429405,-0.004067565,0.059450254,0.028409207,0.031288758,-0.0062254095,-0.017096117,-0.032341767,0.004476495,0.040134754,-0.02627132,-0.09563475,0.09365796,-0.06306986,0.031994384,-0.0030298876,0.06920313,0.019767195,0.08383218,0.066224076,0.020782007,-0.026281381,0.016322771,-0.011552909,0.007772225,0.0012163038,-0.03836893,0.06425956,-0.08405649,-0.08217385,-0.083524235,0.019138128,0.035666462,-0.0327104,0.065704204,-0.014157772,-0.006851548,-0.048102167,-0.010836192,0.017239256,-0.05648339,0.0047810357,0.012998698,0.014235605,-0.012763208,0.043990288,0.01819024,-0.026312804,-0.053996116,-0.05662004,-0.0075846706,-0.02304883,0.026913011,-0.051563546,0.054283034,-0.100058354,-0.028726315,-0.028432772,-0.012817337,-0.016010186,-0.020044545,-0.035296217,0.028694423,0.072112866,-0.0067810453,0.0072369426,0.020371238,-0.024638677,-0.020960974,0.043711882,-0.03119121,0.049187504,0.0036741272,0.08552051,0.08100649,-0.0015598985,-0.004710979,0.05224827,0.05405037,-0.031821482,-0.0065271384,-0.026248261,-0.01536639,0.03195748,-0.03307641,-0.022173608,-0.026143271,-0.023901263,0.011353762,0.0004043532,-0.0029628724,-0.0077513163,-0.05657185,-0.0066551906,-0.054382004,0.03710319,0.022357121,0.025130672,-0.02102532,-0.07403778,0.026163999,-0.08200382,-0.030725952,-0.03522853,-0.019059272,-0.041199725,-0.115725175,0.064924344,0.008673824,-0.07107752,-0.017190672,0.02642063,0.12282637,-0.014770287,0.06541475,0.030359678,-0.070584774,0.026623297,-0.008559691,-0.07841274,-0.0730587,0.042956736,-0.0023007784,-0.04982834,-0.017309139,0.044706896,-1.5691533e-33,-0.0049997573,-0.048537232,0.011456381,0.001103542,0.04638842,0.03283374,-0.046824235,-0.05590755,0.016128216,-0.08884766,-0.026352257,-0.005347404,0.03859557,0.06020138,-0.020413307,-0.036653772,-0.0077332803,0.025240684,0.07142963,-0.028569287,-0.03939272,0.087239504,-0.057409808,0.012191654,-0.030662276,-0.0222104,-0.0126995845,0.03736048,-0.009521824,-0.025250213,0.06375638,-0.051863447,-0.010489021,0.057481825,-0.006549142,0.06876305,0.049709227,-0.04628115,-0.044365514,-0.055811007,-0.0384447,0.045256607,-0.10241321,0.014432892,0.009472106,-0.024372524,-0.043526184,-0.05763969,-0.017529624,0.0047654733,0.013711146,-0.028003188,0.00034480094,-0.099736854,6.548446e-05,-0.015759341,-0.031750683,0.08426674,-0.008958374,0.030567585,-0.03861113,0.04411405,0.013354674,0.017585943,-0.043741714,0.022900058,-0.08210004,-0.04986454,0.026026508,-0.004808887,-0.07083222,-0.03576278,0.002733998,0.029146573,-0.0053678304,-0.047440827,-0.018277807,0.062471952,0.0061885184,-0.03708356,-0.024651624,-0.09504026,-0.024199767,0.14436434,-0.07622119,0.03612144,-0.003345899,-0.03480992,0.110542,0.021054268,0.06921315,-0.0031722372,0.021710556,-0.0081115365,0.09316914,-1.4805995e-33,0.07029183,-0.13152708,-0.0030160001,0.07057393,0.02583722,0.054794163,0.029787898,-0.050950836,0.08249281,-0.087427035,0.061647024,-0.028647227,0.035462007,0.0112948865,-0.013831059,0.069546506,0.043744575,0.10462972,-0.030820077,0.03880282,0.015331409,0.11769357,-0.03464973,0.05902661,0.02302877,0.07834686,-0.07259579,-0.013937322,-0.036424555,0.02910072,-5.3706786e-05,0.013672199,-0.079820395,-0.09929361,-0.0061045103,-0.041612264,-0.038299948,0.015019413,-0.101338714,-0.019099088,0.036611766,0.028201489,-0.0074639088,0.09192376,0.01925414,-0.0043501426,0.07904476,-0.08485976,-0.0077476134,-0.008222725,0.025763877,-0.021130467,-0.019058373,0.017556354,0.040538594,0.087852955,0.07668533,-0.10540177,0.00346513,0.021460434,-0.015416327,-0.05516891,-0.009274337,-0.08524645,0.041175585,-0.031408668,-0.059252318,-0.047254745,0.11688514,-0.053322807,0.07914486,-0.04670759,0.040536847,0.122205235,-0.019815871,-0.023080554,-0.03254847,-0.10594886,-0.040919926,-0.08567506,-0.18271343,0.02472589,-0.012125658,0.022527978,0.04262088,-0.03780908,-0.011892614,-0.01644872,-0.0072582425,0.04961365,-0.010706322,-0.025418913,-0.019447753,0.026577026,0.03889148,-1.9881092e-08,0.03435058,-0.06753263,0.06625302,0.0013448695,-0.1025633,-0.015533057,0.065635785,-0.03549123,0.015842326,-0.04977139,0.03131544,0.15479502,0.071164645,-0.0125671765,0.067124404,0.012131762,0.041457422,-0.002378358,-0.062393583,0.013579274,-0.13474627,-0.06662697,-0.02105482,0.020370154,0.009532659,-0.0043032817,0.009979921,0.16217457,0.0075275144,-0.037028152,0.086765885,0.00041750065,0.08844702,0.014332932,0.066566326,0.07324758,0.10181398,-0.043810602,-0.032585755,0.00327995,-0.012359997,-0.030939037,-0.046793964,0.04539488,-0.014403668,0.025823759,-0.019070718,0.034408607,-0.03655519,0.030019008,0.031155579,-0.016386991,0.025022944,0.014211144,0.0063105463,0.021108463,0.040071443,0.01334858,0.013964994,-0.035058726,0.066028826,-0.008030324,0.16016641,-0.057421666 +2.8.3.3,The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 4.1.1.9 malonyl-CoA decarboxylase.,384,0.99999994,0.0011721803,0.023349334,-0.011717572,-0.003274017,0.058225937,0.047335926,-0.14822768,0.035237968,0.049686093,-0.054257113,0.009827696,-0.099205956,-0.094360694,0.02542063,-0.05539318,-0.025758326,-0.04608235,0.023568124,0.0006841629,0.027284844,0.055422645,0.027061407,-0.06173787,0.039114624,0.016816802,0.07224154,0.083980516,-0.025930213,-0.016775798,-0.086792715,0.01807893,-0.053872366,0.12223961,-0.031766653,0.031215461,0.062405568,0.014744549,-0.05412486,0.14347407,0.010390151,0.057991482,-0.03779987,0.040817898,-0.06131797,-0.04560477,-0.028335312,-0.0048943935,-0.013933654,0.09935374,-0.08420105,-0.0027671913,-0.007960581,-0.048312936,0.025085155,-0.032220997,-0.01758619,0.008291956,0.002456596,-0.056663446,-0.016486125,0.064217195,0.032344244,0.0030371912,0.024764517,-0.05232179,-0.0023453461,0.01236508,-0.03632578,0.03865399,-0.012343489,-0.07026464,-0.03518454,0.033729516,0.0046115,0.030765522,-0.010416627,-0.020764906,-0.090029456,0.05025894,0.020049162,-0.018042594,0.012948156,0.016150558,0.0059457994,-0.00931663,-0.06520568,0.04462518,-0.030473975,0.0657443,0.00434357,0.05022496,-0.026698587,0.022718176,-0.0124792885,-0.017068567,0.12197152,-0.029374776,0.04602426,0.033603515,-0.042475767,-0.0057404805,0.017382268,-0.06462118,-0.0969978,0.0055550765,0.05396409,0.048388105,0.0972007,0.032285985,-0.019113261,0.007402942,-0.11029992,0.034856353,-0.021382088,-0.02205979,0.08854045,0.0060216044,-0.053230498,-0.044727296,0.00087495224,0.092192516,-0.09118332,0.050698712,0.010371692,-0.00709476,0.053950686,-0.12298202,1.5312458e-34,0.054226223,0.023228182,-0.005332727,-0.052921705,-0.01842667,-0.03275888,-0.07764694,0.07820599,-0.0630674,-0.035112895,-0.03296992,-0.027837677,0.01998796,-0.022805875,-0.05293665,-0.051229745,-0.0065373555,0.0034147738,0.01869634,0.00795631,0.027908675,0.014471655,-0.05003603,0.049612112,0.031393267,0.060118414,0.018086031,-0.008795817,0.053337976,0.017615763,-0.037557244,-0.0074861967,-0.072151884,-0.014383581,0.014119213,0.020115862,-0.04159589,0.0038822212,0.015725449,0.07805307,0.08344356,0.026919028,-0.029980274,-0.09402783,0.07972886,-0.012742724,-0.0642989,0.11872672,0.056737483,0.059431113,0.019605404,-0.058462676,0.023624633,0.053797822,0.027034545,0.0044319048,-0.05764737,0.025360785,0.034167096,0.025041735,0.040432602,0.07602588,-0.066199735,0.002081277,0.00863495,-0.0009966451,0.0038459857,-0.020681825,-0.04160865,0.02892579,-0.09395495,0.01264482,0.02349675,0.024301874,0.048816387,-0.07879668,-0.03009787,0.042595815,0.065222785,0.019101886,-0.014590354,0.052909065,0.023916464,-0.050975554,-0.0491098,0.055167653,-0.04275035,0.087906726,-0.034666378,0.042100873,0.06837455,-0.098174006,-0.020677457,0.07883911,-0.07985952,-1.2228233e-33,0.08870376,-0.123273104,-0.012735662,-0.04812351,-0.05889964,0.069843374,0.02617509,0.006979394,0.03616004,0.045893475,0.06723106,0.005514991,0.057344966,-0.027968558,0.049651675,0.06453812,0.02823456,-0.0008201302,-0.042297874,-0.02310633,0.023340318,0.08307521,-0.047333036,-0.00046868343,0.05966514,-0.030275252,0.0071756616,0.0976698,0.0043283803,0.104297705,-0.049359564,-0.0017479056,-0.034870375,0.002851411,-0.062290072,0.021852458,-0.03921747,0.004970422,0.037322212,-0.016326364,-0.009367267,0.00085036317,-0.030232282,0.08078615,0.0387918,0.006381759,-0.07019197,0.050075166,0.03066394,-0.057455808,-0.027307179,0.030249078,-0.041581053,0.007774572,-0.06885072,0.061769366,-0.04106411,-0.0030600482,0.019430209,-0.031945236,-0.105384596,-0.06891947,0.052024905,-0.041987196,0.061765984,0.09445772,-0.07814835,0.04553512,0.04619575,-0.04048962,0.08660607,0.01916041,-0.026439566,0.009022651,-0.02395672,-0.006380517,-0.08842837,-0.06997174,-0.0020911498,0.04704601,0.002324029,0.0028730254,0.029208366,-0.11345463,-0.023115091,-0.075408794,0.059025742,0.1499913,-0.075357996,0.05323623,-0.013439761,-0.062288422,0.060465913,0.0752663,0.06799173,-2.7152632e-08,-0.006591179,-0.027378952,0.057161987,0.0152705945,-0.0012502327,0.09586061,-0.0026931872,-0.0018429714,-0.0061521805,-0.072720155,-0.027082285,0.014384509,-0.03976097,0.06982243,0.06047686,0.0047060098,-0.09690512,0.012803024,-0.03133903,-0.03106749,-0.031429723,-0.05313303,-0.086687595,0.013526051,-0.035040904,-0.0042780833,0.08638779,0.015461205,-0.03161993,-0.033413213,-0.060482275,0.055278596,-0.01381905,0.00446417,-0.07024639,-0.07131676,-0.03261896,-0.020069456,-0.032300074,0.028366754,0.093628235,-0.06944866,-0.07380113,-0.031678088,0.012071464,0.027246846,0.021205058,-0.0010842709,0.006587094,-0.054508746,0.08708549,-0.02609423,-0.036441244,0.05297711,-0.020547524,-0.026035255,-0.01306364,-0.0735685,-0.035121076,-0.003813722,-0.037765518,0.028318329,0.17000075,-0.0026850456 +2.8.3.5,"Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.",384,1.0,-0.03889059,-0.1085041,-0.056214936,0.05623091,0.06092997,0.043188144,-0.036584742,-0.0055673867,0.040044736,-0.08154765,0.10857976,-0.041302975,-0.09286616,0.027507812,-0.03996188,0.08558303,-0.025231037,0.055287518,0.03756709,0.06278392,0.023561828,0.03719793,-0.04482597,-0.008919863,0.02468212,0.060502086,-0.023016827,0.030552277,0.021286782,-0.14243758,-0.053600125,0.004789703,0.04136574,-0.019824307,0.016460767,0.041689463,-0.053280957,-0.0071856882,0.013802678,-0.0054107304,0.05923167,-0.09981764,0.012355228,0.022281285,-0.055187453,-0.09755016,-0.04061282,-0.025393406,0.06021392,-0.054673247,-0.07272552,-0.043341625,-0.13277486,0.104800746,-0.052890036,-0.04348242,-0.02844878,0.0030179606,-0.022290144,0.016589848,-0.0013115826,0.03997617,-0.06101729,0.005674872,0.017589845,-0.012413144,0.044222847,-0.019436209,-0.01594117,0.040626764,-0.0012076775,-0.026773611,-0.006512419,0.057436865,0.0414959,0.027897144,-0.026663905,-0.058561318,0.031794894,0.022726387,-0.008996537,0.07190619,-1.6780634e-05,0.036210544,0.04258377,0.0009531848,-0.05332634,-0.052510884,-0.021216637,0.037636455,-0.018235851,0.018837443,0.036226563,-0.077537335,0.027373157,0.07258587,0.09409672,-0.00041396625,0.022708561,0.052927323,-0.044685293,0.018841758,-0.08480426,-0.053187132,-0.021303494,0.025144627,-0.0002490382,-0.017805094,0.0157221,0.051936653,-0.053843886,-0.1314737,0.023743078,-0.051285945,-0.061699934,0.07406919,-0.02214926,-0.089164585,0.02399977,-0.018737433,-0.034373555,0.010104286,0.09005007,-0.03553469,0.0030680576,0.039219335,-0.014765553,4.2049876e-33,0.068077974,0.007046035,-0.03605046,0.01191608,-0.033243287,-0.031735525,-0.05066783,0.03449255,-0.008297438,0.00941188,-0.05860021,-0.029493015,0.028456084,0.06622111,0.010640393,-0.05800577,0.008573419,0.043600086,0.026579458,-0.03792784,0.025078824,0.041947525,-0.0042034504,0.021617915,-0.074532166,-0.03222285,-0.038433507,0.044035584,0.055194356,-0.008598276,0.09657278,0.034450743,-0.0059417165,-0.019727247,-0.015698586,-0.0058313287,-0.04536917,-0.046051443,0.030102992,0.02420547,0.042841624,0.057660192,-0.076120086,0.019234614,0.064671956,-0.029562905,-0.038531173,0.06046005,0.008599288,0.054011796,0.026184322,-0.048838094,-0.050921008,0.017125046,-0.055323258,0.015182714,-0.03359168,0.068628125,0.010529987,-0.03692969,-0.03571568,0.05109096,0.028902955,-0.0010692043,-0.02854875,0.019624274,-0.06378265,-0.04896727,-0.0331876,-0.03419679,-0.015079195,-0.05187454,-0.03296629,0.06234747,0.040593173,-0.08687673,-0.02507617,0.018790139,0.048877336,-0.032500856,0.021759026,-0.034200635,-0.009850331,0.07686275,-0.100463375,0.02254749,-0.010639001,-0.03151863,0.04100943,0.038143937,0.03958374,-0.0070574293,0.005277269,-0.037796695,0.016090935,-4.7185434e-33,0.10845049,-0.14345257,0.072865576,-0.05883707,-0.04668269,0.09292004,0.025347266,-0.023243293,0.046373874,0.018771727,0.09662374,0.027775025,0.068470225,-0.072829194,0.012952146,0.010329416,0.0014246977,0.03903477,0.022435077,0.05814447,0.027515197,0.038965162,-0.07587675,0.07889145,0.089755535,0.0055954144,-0.037675884,-0.030395929,0.017021649,0.058474675,-0.036768753,-0.012545496,0.00024396842,-0.019713981,-0.03857676,0.045524053,-0.054544028,0.022579575,-0.14151163,0.018106246,-0.055363875,0.013105954,0.015787886,0.11698986,0.086574025,-0.0304913,-0.093063004,-0.025971131,0.034819137,-0.008320167,-0.00565759,0.01692666,-0.085651636,0.02440719,0.059413407,0.1014034,-0.008027232,-0.09089599,0.036007784,-0.036727134,-0.05084244,-0.025924424,0.020132843,-0.0537172,0.12873678,0.077071816,-0.047086727,0.005658263,0.03221046,-0.05780419,0.08628964,-0.017010096,0.072154574,-0.03148504,0.07312404,-0.12418895,-0.037354834,-0.020340342,-0.12657975,-0.035944916,-0.055787046,0.016595675,0.002715778,-0.028262816,-0.1362971,-0.006709285,0.030010093,0.045635153,-0.03345802,0.04621801,-0.018942561,0.02865658,0.027047977,0.067705624,0.058450174,-4.4948397e-08,0.0009421401,-0.033677205,0.12950434,0.0015008118,-0.01708049,0.009241822,0.015353321,-0.02692933,0.02639668,-0.015583492,-0.002573484,0.12598887,0.054605696,-0.017094491,0.08396752,-0.059508864,-0.018303024,0.07665631,-0.07002484,-0.022943137,-0.113260694,0.006855472,0.007176598,-0.0047687856,0.019857273,-0.02661582,0.026052766,0.057605725,-0.0105118565,0.031341255,0.02425175,0.06090199,0.057531938,-0.052819118,-0.033043668,0.032315027,0.020992892,-0.04813953,-0.07389955,0.027524304,0.05331606,0.00026162065,-0.09404921,0.021567987,0.03097251,-0.0039315308,0.019381568,-0.007685075,0.0023198605,-0.070195645,0.040830605,0.009794097,-0.064922385,-0.00186728,0.0049372055,0.030695299,0.013320333,-0.014168894,-0.025075454,-0.05227198,0.0016493684,-0.04824441,0.18431164,0.028690876 +2.8.3.6,"The enzyme, often found in soil bacteria and fungi, is involved in the catabolism of a variety of aromatic compounds, including catechol and protocatechuate, which are degraded via 3-oxoadipate.",384,0.99999994,0.032374308,-0.10656326,-0.050110776,-0.013760779,0.06940843,0.048512887,-0.06254044,0.023646487,0.08166236,-0.019747902,0.050782695,-0.014006867,-0.07490075,0.024323022,-0.083105564,0.032992013,-0.06741963,0.060015865,-0.007048521,-0.01083921,0.025622519,0.063777715,0.007375955,0.01170389,-0.022494458,0.0017207775,0.011203754,-0.032255705,-0.026542602,-0.04506179,0.017144514,0.04514657,0.025460681,-0.029525124,0.028022172,0.09437332,-0.049099702,-0.063362435,0.064968936,0.03857196,-0.0125310905,-0.041643955,0.01383119,-0.09460564,0.008896878,-0.0741768,0.0219033,-0.071271814,0.05521149,-0.074974634,0.012712187,-0.03667543,-0.003172809,0.03427795,-0.037494883,-0.025643304,0.021103848,-0.012426524,-0.12427682,0.03944291,-0.00033490796,0.08386683,-0.006125092,0.0066212295,0.03626483,-0.06065439,0.03498736,-0.044456974,0.03947915,0.0013295064,-0.0714595,-0.10156645,-0.0053594257,0.02136367,-0.016566828,0.037518073,0.048850145,-0.027120119,0.0478242,-0.09090154,0.06032463,0.041820295,-0.00799006,0.07054766,0.022898246,0.04187602,-0.014608969,-0.03841338,0.08251683,0.0029978917,0.05213408,-0.0004778536,-0.0066424618,-0.018193122,-0.052441083,0.020424174,0.0594201,0.02911638,0.0031253595,-0.029941522,-0.012142499,0.051175073,-0.04403386,-0.11330691,-0.077567376,0.08149763,-0.005818766,0.026976772,0.08381003,0.0322849,0.005291653,-0.01606588,-0.016019793,-0.030076342,0.021189384,0.08408877,0.113081634,-0.05863613,-0.10817252,-0.0042429273,-0.059667543,-0.063904725,0.05629285,0.026779748,-0.054145753,0.005182457,-0.020102143,-4.429331e-34,0.07478373,0.005501112,-0.043423492,-0.036000546,0.052917883,-0.03264331,-0.053798452,0.012146211,-0.03425389,-0.05385146,-0.095692724,-0.031384442,-0.049609154,-0.0048969756,0.00015890617,0.01100681,-0.049810328,-0.012087416,0.10462351,0.022132624,0.035066344,0.06623711,-0.019016035,0.030820692,0.03759249,0.0013161674,0.0076984996,-0.015781859,-0.023046719,-0.019129658,0.059802044,-0.053237107,-0.1396825,0.021862274,0.0016411922,-0.024758872,-0.024862008,0.048684485,-0.010276429,0.09600415,0.047511503,0.026664497,0.029398823,-0.030336477,0.07168988,-0.05214182,0.0031710519,0.14906323,0.06742689,0.048567653,0.038695656,-0.020739246,0.1328833,-0.0030112304,-0.05624815,0.025625398,-0.01370054,-0.06792385,0.070426024,0.065772936,0.009957933,0.05136092,-0.0087556,0.0835462,0.024824295,-0.020285206,-0.020913817,0.027364215,0.074283816,0.09166786,-0.09832457,-0.03320305,0.003358467,0.04867905,0.07520506,-0.084202945,-0.12819885,-0.0047128727,0.05572541,-0.0055031083,0.010693802,-0.06747404,-0.01522211,0.020525906,-0.059769318,0.066618934,0.01753947,0.0009426034,-0.020637855,0.043274853,0.04849814,-0.027964411,-0.070626944,-0.033387233,0.055054814,-1.3289092e-33,0.11324188,-0.067898475,-0.049069427,-0.024420112,-0.07021629,-0.01862144,0.014046905,0.032915365,-0.01240883,0.0009436007,0.039508987,0.009558708,0.07072193,-0.032117583,0.020812895,0.030331783,-0.0982138,0.047384556,0.01185096,-0.02693375,0.0012228095,0.037761346,-0.07827175,0.0018045782,0.029734332,0.020243427,-0.03988043,0.017105037,0.02571749,-0.040719297,0.04599511,-0.0056083924,0.027508672,-0.033653263,-0.057110466,0.069841415,-0.06695723,-0.034210343,0.008788365,0.016520845,-0.008617635,0.04606455,0.025516948,0.0055618114,-0.0013104243,0.04182179,-0.15326293,0.002090028,0.028669935,-0.041251272,0.039060447,0.008478003,-0.0016619238,-0.0048527475,0.057092354,0.06923452,-0.031745467,0.010379264,-0.08838659,0.03860453,-0.031049635,0.0008701818,0.0028087366,-0.0049404246,0.049569555,0.05254285,-0.0020009466,0.07826279,0.034784637,-0.041568764,0.08888264,0.03048269,0.042808566,-0.001098209,-0.016364215,-0.016907584,-0.014746854,0.010896398,0.007254993,-0.032726415,0.05382651,-0.03640798,0.04736209,-0.091094986,-0.06300217,-0.05684326,0.0049420497,0.11839087,0.010339209,0.03401137,0.032941602,-0.020380748,-0.027458329,-0.0029922912,0.08557608,-3.586117e-08,-0.03814989,-0.027278136,0.041823983,-0.033580218,0.011561271,-0.031189194,0.08662078,0.045840606,0.0443864,-0.03419191,-0.06551113,0.07686219,-0.006184736,0.026493896,0.04268363,0.028575096,-0.044432923,-0.015739542,-0.07282805,-0.007228371,-0.08451659,0.0053180056,-0.14202547,-0.03026926,0.06480826,-0.022579689,-0.031233365,0.02219676,-0.061179645,0.03639156,-0.016836777,-0.00077128015,0.0029691553,-0.06789773,-0.025647854,0.049986072,-0.050146293,-0.14887667,-0.020181732,-0.032563988,-0.019208288,-0.07482342,-0.03984406,-0.053217452,0.023585984,0.010894828,-0.03433876,0.036531232,0.025982875,0.002674018,0.029706053,-0.00853034,-0.014952384,-0.03551823,-0.08198072,0.027929913,0.0010532096,-0.04727281,0.007085853,-0.09229203,0.008541164,-0.0012217307,0.22196397,-0.052555896 +2.8.3.7,Itaconate can also act as acceptor.,384,0.99999994,-0.04196904,0.028392673,-0.08810775,0.039448302,-0.03439674,-0.013533095,0.07465069,0.010335119,0.013328181,0.038673844,0.05745717,-0.04418099,-0.04854102,0.034298383,-0.0008127689,0.018234897,0.012695785,0.00945594,0.0045806947,0.021461742,0.0079401275,0.042644512,0.0045029926,-0.06181204,-0.050400686,-0.0127577325,-0.051563025,-0.052873176,-0.0072411415,-0.1085952,-0.04943677,0.037145223,0.0410706,0.06639147,-0.10785647,0.02240796,-0.056981813,0.004355116,0.011733037,-0.04636453,0.01947267,-0.008735653,0.0017748808,8.72824e-05,-0.080112636,-0.028081343,-0.042396188,-0.0014498893,-0.064090684,-0.046390895,-0.021053262,-0.026138792,-0.0011783001,0.027997553,-0.055623718,0.0590019,-0.030281905,-0.023526916,-0.035025705,-0.01012379,-0.0054477006,-0.004064043,-0.040593244,0.07185993,0.030509831,-0.012526873,0.033668883,-0.050449114,-0.034115013,-0.070617236,0.008488905,-0.026773859,0.0372209,0.024460234,0.06192218,0.07113004,0.0062414054,0.03636474,0.050745547,0.03994359,-0.09143922,0.045409206,-0.040583983,-0.02794468,0.0018028191,0.019811055,-0.050376873,0.024594277,-0.04029374,0.10604471,0.0897472,0.006813916,0.02509861,-0.0057394267,-0.0077919015,-0.030241907,0.10855569,-0.07297277,-0.025977885,-0.029766826,-0.0084383115,0.025232185,-0.09933361,0.009650085,-0.034541246,-0.04322782,0.03099085,-0.17587844,0.03586908,-0.015464838,-0.10160929,-0.07029298,0.060055174,0.053130075,-0.071653105,0.077683106,-0.052179456,-0.05999872,0.06316971,-0.06733608,-0.048652288,-0.024879485,0.018709011,0.012430933,-0.05456795,-0.047929432,-0.01813251,-2.019903e-33,-0.01760933,0.011314559,0.022258008,0.00652679,0.02232416,0.031528287,-0.037225235,0.020187339,-0.0145196235,-0.072665185,-0.15168478,-0.015278025,0.015419772,0.080420874,-0.009823222,0.02557478,-0.03465678,0.048155427,0.058524344,-0.03173775,0.01201357,0.089441836,-0.08128123,-0.031717833,-0.0040455502,0.061205115,0.013905675,0.001482548,0.014094983,0.027032424,0.07225657,-0.06372244,-0.03967457,0.07019509,0.040305864,0.051088605,0.019076249,0.001493226,-0.05290138,-0.06888857,-0.027003681,0.0152532905,-0.0559296,0.08709364,0.026157007,-0.02078449,0.019217538,-0.039839987,-0.033064418,0.020334883,-0.020588765,0.0048776576,0.054195065,-0.05611643,0.010627083,0.07277798,0.056556825,0.09912511,0.005670691,0.02691098,-0.0037278656,0.085321635,-0.017428678,-0.031403895,0.0050491756,0.07696948,-0.09225786,-0.11539845,-0.03005574,-0.0034346045,-0.048976175,-0.00097472704,-0.051156886,0.08003087,0.015660893,-0.039229594,-0.0017305209,0.043805413,-0.041816343,-0.030591078,0.019164473,-0.04553192,-0.0028398235,0.04654148,-0.035815604,-0.005233792,0.010258059,-0.06999316,0.014162295,0.0492555,0.11544031,0.022638418,-0.004866793,0.02131448,0.12987325,-9.109897e-34,0.0185749,-0.113020696,-0.041506335,0.06340084,0.042800386,0.09677401,-0.00023806306,-0.012800816,0.018353451,-0.04545538,0.024980638,0.044810377,0.07856116,-0.024175549,0.034824744,-0.007925043,0.026844462,0.082129054,-0.03995304,0.042498894,-0.07320032,0.037618626,0.006009583,-0.02100788,-0.0073961355,0.02714061,-0.01706333,0.0186221,-0.035320383,-0.0039524785,0.045154855,0.0036462513,-0.07249967,-0.05677035,-0.0033758064,-0.08993896,-0.09470125,-0.043445386,-0.045135792,-0.012929153,-0.0089253625,-0.061137285,0.022018228,0.09977545,0.06025496,-0.018916303,0.0063107363,0.013590315,0.00887428,0.019185957,0.039216712,0.02739391,0.017625364,-0.009047476,0.14766365,0.035238337,0.13390554,-0.11731282,0.01773254,-0.03311281,0.009238697,-0.059148256,0.06436821,-0.0008162896,0.051490296,-0.007982169,-0.021356292,0.05257708,0.06578552,-0.018550303,0.15743648,-0.1161519,-0.029427258,0.010414241,0.035150364,0.017383957,0.0077105653,-0.06349172,-0.013281488,-0.026284723,-0.103362635,0.04974614,0.0859345,-0.053379126,0.031295523,-0.13326876,0.04320815,-0.051603418,-0.06497877,0.069184974,0.0026103929,0.035051886,0.01628934,0.021403924,0.04613447,-1.9003199e-08,-0.027813662,-0.053457066,0.08105864,-0.0057134717,-0.023350298,-0.007230731,0.047662888,-0.05468189,-0.016383719,-0.05764173,-0.01600049,0.024807272,0.085823126,0.021918967,0.12688993,-0.019609079,0.024537744,0.014976771,-0.08286294,0.021329816,-0.115104556,-0.035773274,-0.014951332,-0.09058564,0.037345357,0.02952474,0.024987204,0.014960703,0.07403972,-0.025359409,-0.026648493,-0.012960723,0.022801101,-0.004471184,-0.08190056,0.1016205,0.04649895,-0.060076036,0.023766713,0.014685095,0.050456934,-0.013421615,-0.038510963,0.05390462,-0.06452487,0.09106387,0.046191387,-0.002487601,-0.068472356,-0.008198576,-0.02808717,0.01166696,0.04414983,-0.0015171333,-0.060434602,0.010925887,0.021475881,0.009372773,0.00857607,-0.034742437,0.034163147,0.0029502173,0.08220155,0.057657942 +2.8.3.8,"The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC 2.8.3.9, butyrate---acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA.",384,0.99999994,-0.08376608,-0.042381223,-0.030060016,-0.078069896,0.06885516,-0.026767142,-0.08003638,0.05150648,-0.0070688827,-0.026624283,0.02095724,-0.08425544,-0.061693437,0.025531674,-0.043840874,0.022892118,0.026249534,-0.084299766,0.032250788,-0.039475188,0.069794744,-0.024371803,-0.025639571,-0.030529188,0.07634707,0.05458688,0.037106313,-0.0044961777,0.045079544,-0.1327336,-0.08609229,-0.053294454,0.015822021,0.0028048898,-0.039536554,0.05885008,-0.050881322,-0.09681091,0.0006432895,0.0051850546,0.08619115,-0.03336204,-0.004081865,-0.08411345,-0.0069184876,-0.090660974,0.05197492,0.0152801,0.005218261,0.045273695,-0.0020692095,-0.049424738,-0.031283777,0.05948815,0.004070487,0.01612433,0.018475039,0.0074303453,-0.011332868,0.012494012,0.036777783,0.03822844,-0.048847582,0.014361998,-0.00060151203,-0.09237339,0.047502764,-0.011963993,-0.011334721,-0.054134585,-0.049836475,-0.03172662,-0.0981111,0.086524844,0.059214722,-0.00681859,0.0003551083,0.0025271135,0.034496367,0.0059261015,-0.015541754,0.014986167,0.024279915,0.028725035,-0.02539918,0.006963133,0.00784374,0.043492045,0.07593387,-0.046664625,-0.014058724,0.032523874,-0.06383906,-0.041155934,-0.08452124,0.106076114,0.0319384,0.07701909,0.029407538,-0.00055873476,0.0048468974,0.06283912,-0.040536024,-0.0156080015,-0.049477104,-0.0033923616,-0.027018242,0.046198383,0.046200037,-0.0017620629,-0.037699822,0.007980389,0.061473638,0.047232404,0.020616844,0.029708678,-0.019866766,-0.022343721,-0.00994272,0.063969806,0.05849755,-0.007104966,0.037224226,0.08981567,-0.015140351,0.07543291,-0.09335534,9.281274e-34,0.031034091,0.046853047,0.038630277,-0.03298439,-0.0063600787,-0.094064616,-0.10349591,0.060036488,-0.034031965,-0.008314674,-0.012559841,-0.03938096,0.03215845,0.087689884,0.022423787,-0.07688913,0.06982626,0.0013676159,0.082338326,-0.00077021576,-0.010880169,0.004992293,-0.05732781,0.03698967,0.029273028,0.06817967,-0.019896835,0.13060285,0.049323753,0.0061273314,0.017272206,-0.07416159,-0.082533635,-0.050837513,0.018475352,-0.06817743,-0.036913052,-0.008043797,-0.01888497,0.06325387,0.069525495,0.012914593,-0.051422592,-0.013736449,0.04852066,-0.10917105,-0.010009367,0.056611326,0.030184047,0.024516948,0.015599056,-0.0856779,0.08811721,-0.052992612,0.009578509,0.082313105,-0.014201959,-0.027722817,0.06076224,0.024037214,0.023651823,0.03695615,-0.01610499,0.072514325,-0.03691682,0.05014954,-0.09651518,-0.07258553,0.035683095,0.048863757,-0.051242944,0.03474782,0.0026242912,-0.000769513,0.042338982,-0.07568489,-0.053838544,-0.008513828,0.090460226,-0.035374507,-0.027583882,-0.01198148,0.017057566,-0.04725713,-0.054654572,-0.07098565,-0.026448848,-0.034828953,-0.016993444,0.07153272,0.037785504,0.007542924,-0.0010282204,-0.0025571552,0.08726544,-1.5547347e-33,0.1330236,-0.08258321,0.013321686,-0.13705899,-0.04419623,0.070412196,0.09082624,0.0046361447,0.057230797,-0.0049427003,0.01593859,0.0103694415,-0.0021173614,-0.05491206,0.042665917,0.046460442,0.05038398,0.056496955,0.0011219875,-0.035056524,0.027378911,0.038534507,0.029698495,0.02949505,0.030638115,-0.036487553,-0.02895432,0.030277394,0.008934254,0.06567203,-0.022955514,-0.063907154,0.02029544,0.0036236295,-0.011770539,0.028822772,0.048867133,0.026961135,-0.014336899,-0.023338849,0.009416252,0.04125692,0.0051776925,0.07812873,0.02751269,0.024397511,-0.052022792,-0.030428085,-0.075644955,-0.09737294,0.024546972,-0.026268737,-0.028576678,0.00049426197,0.022891074,0.053913724,0.041498657,-0.029329784,0.027849287,-0.12010249,-0.03814279,-0.039598312,-0.060177464,-0.0068031074,0.08950923,0.06791452,-0.040503394,0.03845772,0.011812948,-0.0069143674,0.09489806,-0.027178565,0.03320899,-0.020168979,-0.032195695,-0.022768686,-0.008745979,0.014993245,0.0032106081,-0.05444429,-0.06403383,-0.0283554,-0.046992447,-0.07938548,-0.087754294,-0.08888354,-0.0004499201,0.05424131,0.03294126,0.052282274,-0.060269754,-0.026342088,-0.027294995,0.07828486,0.06087,-4.086785e-08,0.015808234,-0.12022996,0.002771485,-0.0016134311,0.0529744,0.09089158,-0.012276931,-0.04000099,0.081226066,-0.0027600687,-0.05038113,0.10974568,0.07317525,-0.0086756,0.05016394,0.010598554,0.08494857,0.03393901,-0.038181223,-0.01598436,-0.045240626,0.025924966,-0.032282393,0.026068578,0.01343448,-0.043901723,0.005486398,0.08432548,-0.03335703,0.0033101318,-0.04901194,0.05525542,-0.013953998,-0.009651616,0.007310973,0.001981721,0.09174051,0.008755379,-0.01744114,0.07142036,0.050641846,-0.06482106,-0.078002885,-0.038974315,0.050830882,0.0458152,0.018928753,-0.0045386,-0.007756987,-0.03332958,0.031759426,-0.019898484,-0.054221082,-0.036822435,-0.102267645,-0.014449979,-0.008255125,-0.10511027,-0.035987325,-0.05371081,0.0863842,0.054727297,0.19991904,-0.028852679 +2.8.3.9,"Butanoate, acetoacetate and their CoA thioesters are the preferred substrates, but the enzyme also acts, more slowly, on the derivatives of a number of C2 to C6 monocarboxylic acids.",384,1.0,-0.024691937,-0.081945546,-0.051584393,-0.0030062532,0.036354005,0.09798878,-0.1485963,0.014284659,-0.004426983,0.016239109,0.03495146,-0.08604143,-0.14770755,0.041993365,-0.029808791,0.07688052,0.03587981,0.05103163,0.02975514,0.03224699,-0.0209577,-0.06013248,-0.032247793,-0.00030166615,0.06127906,0.008003751,0.0036081062,0.011121551,0.0680609,-0.12480433,-0.07068052,-0.0010804256,0.03328687,0.000844959,-0.01926055,0.07379001,-0.09451004,-0.067037754,0.0582053,0.0026992038,0.027781354,-0.016530512,-0.03893205,-0.024793811,-0.02278633,-0.10779593,0.059397124,0.007563304,0.047425553,-6.431799e-05,0.040803187,-0.013047913,-0.07916471,-0.023410004,-0.06975407,-0.019502826,-0.06505756,0.050835013,0.0013834727,0.032573123,0.035571493,0.01522992,0.012088712,0.02730487,0.004770109,-0.021052899,0.021731624,0.00792225,0.0067051323,0.016966593,-0.05686465,-0.02403104,-0.020024775,0.02657616,0.061654206,-0.012277392,0.006888346,-0.07054865,0.06561383,-0.062109746,0.02418755,0.04268245,-0.037036795,0.051911965,0.049525637,0.016804283,-0.007560349,-0.012584684,-0.006671915,-0.023374533,0.07800216,0.02659779,-0.044840798,-0.09981194,-0.0550981,0.03433187,0.05397066,0.025150502,0.06273985,-0.006718857,0.03283895,0.052787747,-0.056091078,-0.051354896,-0.036868714,-0.0023652224,-0.06771804,0.031553928,0.044036075,0.008611611,-0.035658494,0.017711025,-0.01975853,-0.005012737,-0.03093157,0.032683942,-0.0004562486,-0.09061807,0.017111449,0.0618922,0.0033419055,-0.020471048,0.07261134,0.10079796,-0.006690856,0.037979655,-0.017467568,6.2905317e-34,0.062001,0.005801919,-0.008068037,-0.055231236,-0.0033327418,-0.023678573,-0.028756704,0.04699273,-0.085447095,-0.011346795,-0.023348896,-0.0197729,0.009552705,0.037584964,0.07911657,-0.09547706,0.015795566,0.023567911,0.004876719,-0.015732171,-0.059176438,0.0035173418,-0.042113055,0.017349731,0.061477616,-0.0081269145,-0.011028974,0.1044685,0.020687196,-0.02717582,-0.030883871,-0.039502215,-0.006921803,0.006251859,0.066040985,-0.022520458,-0.06647514,-0.013210714,0.0018847691,0.011654783,0.077484235,0.051978543,-0.035555787,-0.065166615,0.052069414,-0.024467073,-0.01311281,0.084875815,-0.00042492888,-0.012503532,0.045415863,-0.037489254,0.08123068,-0.059279192,0.03661092,0.048646517,-0.08755498,0.023831282,0.013446579,0.018024715,-0.03787331,0.011753723,-0.018436298,0.10298572,-0.04181399,0.05079194,-0.1132287,0.01791226,-0.013140852,0.014954384,-0.03403835,-0.022482278,0.03742065,0.0059867376,0.026085522,-0.020311898,-0.049979497,0.0343646,0.057189915,-0.06864628,0.03612627,0.023516232,-0.04822416,-0.047989283,-0.07120693,0.021303808,-0.04253355,-0.06790832,0.04032433,0.09626678,-0.011998671,-0.046548784,-0.0100046825,-0.009631561,0.023535693,-3.5938943e-33,0.120604545,-0.14299259,0.030392036,-0.05606382,-0.039145675,0.08686745,0.08584713,-0.09925052,-0.01555941,0.0033388936,0.058593743,-0.00454439,-0.025018474,-0.055707958,0.017544325,0.06438963,0.050143085,0.096634135,0.008902006,-0.02316026,-0.010742969,0.05907269,-0.037115082,0.04830848,0.02368545,-0.011780735,-0.09506783,0.03664451,0.044683605,0.07073771,-0.062412474,-0.009300179,-0.002653014,-0.058140785,0.0020285617,0.08137812,-0.008390815,0.032456137,-0.041656412,0.051670913,-0.012585618,0.03917126,-0.00798014,0.07833635,0.06564717,0.0012690469,-0.109915525,-0.05655579,-0.0048229187,-0.052583303,-0.018097786,-0.067277566,-0.07309265,-0.0016289151,-0.012513771,0.112592325,0.0040254826,-0.09130061,0.01873021,-0.07165122,-0.050192755,-0.07756586,-0.017088417,-0.10598173,0.009383396,0.045924917,-0.06429883,0.027901994,0.011132033,-0.057903618,0.059637744,-0.011775217,0.0032297377,0.041497063,-0.054870572,-0.06667296,0.026879877,-0.05152716,-0.018081117,-0.04203384,-0.038222354,-0.0052617015,-0.05456151,0.03292538,-0.06717016,-0.017342543,0.030473368,-0.016475715,-0.0039416915,0.07004918,-0.018730994,-0.028749378,-0.0053733373,0.07250502,0.031217432,-3.645098e-08,0.07688899,-0.0640846,0.102999896,-0.03418898,-0.024936225,0.021207578,0.016420031,-0.021585895,0.0007676427,-0.07689255,-0.028430684,0.10615409,0.053493064,0.03740088,0.081949875,0.0041863993,-0.026704965,-0.0312972,-0.038210087,0.0107383365,-0.10302488,0.021149755,-0.0011957346,0.003237598,-0.0069751707,-0.07663711,0.06528877,0.0908171,0.012404318,0.047558855,-0.023780797,0.046140123,0.0038987796,0.0052098073,0.0680331,0.026031109,0.02788453,-0.038490918,-0.07677981,0.098136865,0.030039696,-0.05444044,-0.08825834,0.021325128,0.07786703,-0.033196375,-0.016877731,0.04549921,0.010301966,0.026826102,-0.0005675838,-0.0322036,-0.06310298,-0.03271648,0.05654098,-0.030371951,0.0074050333,-0.05257453,-0.056530114,-0.028730031,0.03376357,0.06265122,0.23827717,-0.04140526 +2.8.3.10,The enzyme is a component of EC 4.1.3.6 [citrate (pro-3S)-lyase]. Also catalyses the transfer of thioacyl carrier protein from its acetyl thioester to citrate.,384,0.9999999,-0.05099751,-0.036991645,-0.09551267,-0.014458847,0.12009019,0.05382005,0.020293731,0.09023229,0.038486138,-0.01463896,0.057380907,-0.08063566,-0.07052967,-0.02919763,0.036543984,0.015194612,-0.045633838,-0.0008049927,-0.044891335,-0.12145676,0.04884947,0.022463774,-0.04507933,0.0017293893,0.012369614,-0.01774854,0.042629674,-0.057191346,-0.017784165,-0.10623348,-0.04912394,-0.030584283,0.024445608,-0.041766454,0.013626819,0.092297725,-0.09720824,-0.13795681,0.019687762,-0.022764096,0.0746207,-0.013367066,-0.021506352,-0.037782166,-0.07267595,-0.013925568,0.02405489,0.045618504,0.057787824,-0.006633802,-0.009214809,-0.08715574,0.007167362,0.081913576,-0.11323163,0.038090434,-0.016815098,-0.01482933,-0.036077227,0.034287788,0.053074062,0.08081931,0.0076432577,0.021827206,-0.010766823,-0.053113632,0.04734189,-0.0060052937,0.005887313,-0.030770151,-0.036677003,-0.052042108,0.008205549,0.074147075,0.04485904,0.017869765,0.014364929,-0.042365696,0.033884443,-0.0082267355,0.020627368,0.04377536,0.03173457,0.031298477,0.025742097,0.0023822535,-0.010465892,0.005720828,-0.010960128,-0.013619516,0.09230287,0.001437503,-0.068255514,-0.0048024952,-0.05923001,0.06797667,-0.020475306,0.0031716162,0.03194225,0.008760427,0.026180869,0.120173596,0.006602912,-0.08398553,-0.07448065,0.05173436,0.016321447,0.07350008,-0.016974384,0.0075486167,-0.018006835,-0.093491554,0.056278024,-0.007334262,-0.042263407,0.109164,-0.046227988,-0.046060193,0.03346851,-0.009499086,0.057572648,-0.013636194,0.05922242,0.06913787,-0.06707988,-0.0012308107,-0.07571242,1.0843748e-33,0.030973213,0.03991608,0.023718446,0.002563626,-0.014338203,-0.024113763,-0.077237025,0.016764326,-0.064157106,-0.03756499,-0.10404447,-0.10295672,-0.0016766744,-0.014285711,0.007078748,-0.06363303,-0.018286481,0.01580269,0.075117156,0.052039936,0.037361167,0.033695117,-0.071517676,0.0007973805,0.0014566329,0.115189426,-0.012312718,0.023980657,0.01651358,0.03572506,-0.016197901,-0.031221487,-0.016830327,-0.0102198515,0.014686868,0.018321125,-0.042534556,-0.036851626,-0.040597033,0.0835749,0.05313349,0.016707819,0.0146637475,-0.056102205,0.013175592,-0.070972174,-0.046352386,0.0485972,0.057499222,0.024956018,0.025915932,-0.10331467,0.10408024,-0.06668398,-0.023193294,0.0042901975,-0.06195182,0.021094605,0.037959997,0.02078945,0.014389537,0.0491141,-0.0409141,0.02786114,-0.007938895,0.055509165,-0.12175993,-0.041351188,-0.017820135,0.082202695,-0.11549601,0.022569507,0.07647317,0.010605668,0.07130787,-0.08936116,-0.11714105,0.013996426,-0.011374118,0.056825884,-0.014734887,-0.034558296,-0.02921877,0.0049684527,-0.013582848,-0.056931097,0.0014969195,0.028648399,0.028736016,0.03518216,0.06007946,-0.024943782,-0.028842907,0.09624789,-0.007852166,-2.4269699e-33,0.053996094,-0.07331895,0.083239526,-0.045309078,-0.075083315,0.06728427,0.024730299,-0.0019974757,0.000961934,0.053540077,0.09267425,-0.01748173,-0.005249368,-0.09560162,0.041483216,0.020148065,-0.046281382,-0.032796,-0.028442953,-0.006019607,-0.0002406282,-0.037562113,0.031225689,-0.0024658872,0.051332094,0.00023612674,0.005354435,0.0453224,0.07548135,0.0352549,-0.018316062,-0.048066992,-0.041449707,-0.027156727,-0.11560729,0.005500959,-0.016502863,0.007981275,0.041639797,0.009678117,0.025580237,0.048705406,0.03488144,0.05311732,-0.009754451,0.07771772,-0.043636046,-0.024794068,0.054080594,-0.096971996,0.036711574,-0.010382941,-0.027189584,0.014215834,0.0068939696,0.106167115,-0.007445657,0.0033355276,-0.029238746,-0.05192619,-0.08820316,-0.08144656,0.03476797,-0.04330267,0.093194924,-0.00014097645,-0.07138819,0.10591386,0.055324387,0.022779014,0.073486246,0.008199959,-0.017974056,-0.035106856,0.017331501,-0.061558176,-0.06869821,-0.040438298,0.0017501698,-0.043938383,0.008868341,-0.07184263,-0.03493196,-0.090708695,0.004090465,-0.036757953,0.042490598,0.12046983,-0.0118612945,0.022401493,-0.074056864,0.024386706,-0.0012340018,0.07274723,0.040781386,-3.3189632e-08,0.0017890675,-0.04933623,-0.021209218,-0.03646142,0.0072362213,0.069340184,0.0073220315,0.025636524,0.018293926,0.029882638,-0.08194317,0.074226946,0.023090633,-0.031948727,0.048674837,0.07177585,-0.0011266812,0.06340446,0.03412334,-0.0173784,0.0004959099,-0.0398616,-0.05529834,-0.00043373823,0.00039359852,0.018074095,0.09088729,0.085820384,-0.017452646,0.00789001,-0.08408228,0.014739408,-0.03105619,-0.011115352,-0.02019391,0.062096294,-0.03687294,-0.056141168,-0.07398055,0.029930748,0.05092031,0.034812946,-0.09659014,0.008009914,0.02433314,-0.001918359,0.06613467,0.072206184,-0.048975185,-0.036397655,-0.018505039,-0.087580346,-0.026179712,-0.0012400539,-0.03764702,-0.008621115,0.0031011577,-0.07860769,-0.010250276,-0.033060174,0.032708533,0.017795447,0.18916948,0.0026083637 +2.8.3.11,The enzyme is a component of EC 4.1.3.22 citramalate lyase. Also catalyses the transfer of thioacyl carrier protein from its acetyl thioester to citramalate.,384,1.0,-0.028310219,-0.020741776,-0.069760345,-0.019683646,0.10002847,0.05736126,-0.017826347,0.080999054,0.039970983,-0.02047497,0.076892644,-0.091495395,-0.08112533,-0.022324981,0.03033158,0.035932887,-0.05366601,0.0031463925,-0.058692016,-0.124990374,0.05556656,0.02577026,-0.072396904,-0.0031541395,0.017154232,-0.0089201275,0.02904952,-0.07323927,-0.013995767,-0.11638735,-0.04105552,-0.038822737,0.037719082,-0.040414453,-0.0013289823,0.08132122,-0.09875822,-0.14716677,0.047376167,-0.011423068,0.058024816,-0.024954645,0.0020204245,-0.05603698,-0.07547397,-0.016018579,0.025303623,0.039668906,0.036146116,-0.01438898,-0.021528402,-0.080252156,0.015343396,0.06251437,-0.08971647,0.029434476,-0.032857288,-0.0042537483,-0.017534452,0.053737067,0.059485607,0.098768964,0.0042816936,0.0011362012,-0.03795541,-0.06360548,0.08087658,-0.04058884,0.029651916,-0.035664458,-0.023448396,-0.06335412,0.0070477203,0.0667075,0.02618175,0.0015098657,0.015964381,-0.04346553,0.046956476,0.012122991,0.03037342,0.023385314,0.02902618,0.013000357,0.03288442,-0.007970078,-0.015452263,0.0017258818,0.028499631,0.0067636524,0.10354818,0.008511757,-0.08487499,0.006519513,-0.027317699,0.066032566,0.012460589,0.013546205,0.032476585,0.01855779,0.035026405,0.10890517,-0.013648601,-0.062322356,-0.08245997,0.033176158,0.051292323,0.035052102,-0.027320206,-0.01686065,0.000516925,-0.075254336,0.052274123,-0.0127455685,-0.04020048,0.08767527,-0.027165266,-0.046785984,0.026048664,-0.013129057,0.06388432,-0.0150750615,0.06802277,0.073040366,-0.05819612,0.005671455,-0.086188175,2.3087128e-33,0.039650418,0.058275905,0.0156748,-0.011337291,-0.017665476,-0.029140651,-0.08622556,0.041638244,-0.061779205,-0.058645725,-0.09658195,-0.104282044,-0.027483009,-0.0009835202,-0.004708351,-0.05164757,-0.011849722,0.019305354,0.08065504,0.023593735,0.02702853,0.03156934,-0.07997113,0.0065998766,-0.0146559235,0.112351224,-0.0017013616,0.001990339,0.021069307,0.041115064,-0.033348616,-0.04140045,-0.035791803,-0.01451474,0.005549789,0.013454592,-0.043230653,-0.03852676,-0.034503605,0.057497595,0.058298584,0.03537951,0.018699888,-0.05850761,0.0048489254,-0.019241324,-0.048965055,0.052747104,0.07620617,0.025427157,0.019004285,-0.07979739,0.0882191,-0.064267516,-0.030052619,0.016117405,-0.066720486,0.009540084,0.034148313,0.02552409,0.020205943,0.05141733,-0.030017482,0.016871521,-0.002203694,0.026559735,-0.093473606,-0.06714658,4.3835567e-05,0.05809074,-0.11631505,-0.007106505,0.08828224,0.005205503,0.08666158,-0.118605986,-0.11407828,0.026867429,-0.010007502,0.043660585,-0.02996778,-0.03192717,-0.016766114,-0.021725863,0.003049341,-0.052738655,0.00044552953,0.04629886,0.03801144,0.049805813,0.029156132,-0.042589463,-0.01789292,0.10063827,0.012358489,-3.5203352e-33,0.04833945,-0.07980941,0.071080506,-0.033206213,-0.063234195,0.06986108,0.01580987,0.02388371,-0.005933996,0.046675075,0.107334256,-0.005039697,-0.0022437845,-0.07721928,0.061539426,0.022111584,-0.043685596,-0.007569005,-0.045254722,-0.0066289254,-0.010499428,-0.01826858,0.03579357,0.0140831545,0.07529737,-0.00012742667,0.0070966524,0.045459367,0.05818886,0.027293341,-0.021886285,-0.052137405,-0.030431628,-0.029184304,-0.12966149,-0.0039788955,-0.003279908,0.0024684363,0.04398991,0.021830697,0.03530943,0.05018803,0.027576149,0.06055116,-0.016215421,0.063443065,-0.033535786,-0.029756917,0.048206106,-0.0980331,0.044130936,0.014937195,-0.042277373,0.009922174,-0.0038155043,0.10250425,-0.01819569,0.026670404,-0.026637923,-0.048505764,-0.09334397,-0.10524643,0.0257745,-0.045343153,0.09488354,0.0012515874,-0.063852526,0.109323315,0.05549234,0.014794911,0.07911545,-0.011837314,-0.009077378,-0.023383006,0.030012893,-0.07753949,-0.054383997,-0.07442922,-0.002687933,-0.068980604,0.031845786,-0.07445825,-0.012412074,-0.090066805,0.0111006545,-0.06614213,0.051109813,0.115108445,-0.016231323,0.028939623,-0.06259273,0.027763085,-0.018837344,0.08286056,0.0495699,-3.211056e-08,-0.0031349875,-0.04107796,-0.036642868,-0.02458866,0.0036945238,0.05276008,-0.0017637911,0.044078033,0.012305279,0.027716774,-0.07784051,0.07656312,0.008053473,0.0022766716,0.053977907,0.0623646,-0.026008066,0.06825725,0.0335453,-0.0011997473,-0.006603362,-0.029411498,-0.04677522,-0.015018557,-0.02813105,0.026155818,0.09396025,0.10997478,-0.0059805447,0.008660941,-0.06966542,0.04326007,-0.03142549,-0.0049874354,-0.03932223,0.05620025,-0.047845766,-0.06857166,-0.06072675,0.015965285,0.047122084,0.017224172,-0.09826981,0.015587307,0.018297767,-0.013541615,0.0541956,0.06654531,-0.038685035,-0.02912828,0.002088943,-0.08169787,-0.010880369,0.0030344687,-0.031454593,-0.030560557,0.005100673,-0.059951298,0.0065046614,-0.043331206,0.050274387,0.012098912,0.17234965,-0.010012156 +2.8.3.12,"Glutarate, (R)-2-hydroxyglutarate, propenoate and propanoate, but not (Z)-glutaconate, can also act as acceptors.",384,1.0,-0.07425729,-0.045118432,-0.0621112,-0.0022902505,0.0019579933,0.017573208,0.05636214,0.012396105,-0.06030243,-0.019774558,0.043791957,0.03008578,-0.05085061,0.07772025,-0.035432313,0.036001366,0.04200539,0.0026571262,-0.04548199,0.031285346,0.05483121,0.03675106,-0.018864704,-0.006946235,0.03809905,-0.005431513,-0.020298904,-0.01289793,0.057176996,-0.040594056,-0.061099723,0.0230883,-0.0104762735,0.0017338488,0.024490118,-0.0059825494,-0.11168728,-0.037044816,-0.011054579,0.045844764,0.05401907,-0.06616438,0.0011433118,-0.0143267615,-0.014614466,0.013650813,0.06731405,0.008925215,-0.04688023,-0.016359579,-0.06590067,-0.04801525,-0.05533723,0.08287102,-0.0014749867,0.018526424,-0.08447766,-0.017048342,-0.029692579,0.0017600752,0.0023858703,-0.053684615,-0.10904293,-0.026995888,-0.017308543,-0.054124676,0.01843998,-0.015983667,0.012518651,-0.019706171,0.011947267,-0.050181117,0.07174439,0.008532442,-0.025884915,0.021012345,0.026548514,-0.02289262,0.07234056,0.01074915,0.049176328,-0.023833977,0.031096729,0.06936801,0.03189299,0.06439784,-0.062595285,0.10187581,-0.016961489,-0.023608565,0.029299732,0.03785905,0.060020525,-0.035341088,-0.017087454,0.0059261806,0.081744395,-0.055886913,0.08827411,-0.026134783,-0.019696886,-0.00024040487,0.019111743,-0.0742327,-0.0992275,0.018864019,-0.027772266,0.060897883,-0.007261246,0.036046755,-0.07102911,-0.04177769,0.031090276,0.044003487,-0.08232096,0.043324016,0.058837023,-0.080394424,-0.005536008,-0.086217515,-0.028485266,0.0006845278,0.09533998,-0.024266632,-0.041949194,0.04148693,0.001219215,1.8209588e-33,0.02302711,0.013325327,-0.010906621,-0.0077477554,-0.0024769865,0.10689357,-0.07512638,-0.046451967,-0.0106946295,-0.06682416,-0.10328889,0.0003693985,-0.038227115,0.1252062,-0.05354313,0.059785068,0.003468978,0.035813462,0.026765436,-0.023245882,0.09231126,0.124034815,-0.10056061,-0.01033213,-0.0547737,-0.0073320535,-0.0040384424,-0.04678892,-0.009771435,-0.046477247,0.08043082,-0.047515772,-0.007951809,0.0396689,-0.010145461,0.029593367,-0.07849478,-0.08397645,-0.010658743,-0.07308566,-0.020743845,0.011588711,-0.039965447,0.059110858,0.07208031,-0.010380879,-0.055503897,-0.017665079,-0.023060778,0.069709964,0.050154105,0.049444452,-0.056540478,-0.0234371,-0.07005942,0.034822118,-6.227633e-05,0.07502764,0.07230013,0.032096174,-0.04722976,0.1034675,-0.053971436,-0.007325021,-0.02008194,0.052673098,-0.06716043,-0.014135587,-0.022689827,0.038477585,-0.016547997,-0.056163404,0.053516693,0.08998393,0.05996474,-0.1275966,-0.002014747,0.017809557,0.013157258,-0.029570805,-0.022094607,0.0035494685,-0.022830129,0.13983712,-0.1498556,-0.009825248,0.01291791,-0.02858516,0.05443745,0.036863502,0.026697759,-0.06643975,-0.048883647,0.018997988,-0.0008281325,-2.8695777e-33,0.10049819,-0.10248204,0.026136938,0.06601184,0.048650213,0.01361271,0.07124119,-0.13051368,0.09453915,-0.047309913,0.12688243,0.048214827,0.03830141,0.023783822,-0.016196169,-0.045357037,-0.040743813,0.029976932,-0.07588632,0.026334468,0.027763078,0.03757039,0.06117277,0.033001512,0.03029901,-0.04252182,0.047662728,-0.017162386,0.0638885,0.041152224,-0.019920135,0.024692403,-0.045403052,-0.12623431,0.008466649,0.0026976455,-0.050207146,0.020675397,-0.12174401,-0.025559915,-0.021875799,-0.025232794,-0.026250944,0.10679065,0.04257958,0.04799466,-0.012643397,-0.026352134,-0.0153317675,-0.016344657,-0.010006587,0.044324107,-0.052558836,0.003407407,0.13156343,0.04095557,0.048847497,-0.07933324,0.021686073,0.013999315,0.011314995,-0.06227141,0.044496343,-0.078921854,0.07720557,-0.00060814817,0.010087704,0.056221608,0.045691628,0.07567819,0.13085791,-0.033341467,0.08652646,0.030788673,0.01855317,-0.060167965,-0.055143453,-0.054229584,-0.038528383,-0.076615326,0.023640392,0.01152546,0.04583079,0.04646531,0.059474427,-0.052932218,-0.021240462,0.034355972,0.017414989,0.052833747,-0.018797547,0.00021990934,-0.014770835,0.07883722,0.04074171,-3.2654775e-08,-0.0010331835,-0.013125413,0.058151394,-0.03657638,-0.070611686,-0.04437499,0.03813496,-0.0034447545,0.028419323,-0.026320456,-0.027428119,0.07625609,-0.011786705,-0.023360504,0.0042330413,0.0027338057,-0.008380732,-0.007262822,-0.039261363,-0.028867178,-0.12885149,-0.011951869,-0.088792145,-0.028500851,-0.017996231,-0.0028019801,0.03003256,0.07169661,0.016342016,-0.029919302,0.05333936,0.026062682,0.08980729,-0.025468595,-0.028071407,0.056922987,0.06920217,-0.012251652,-0.054054487,-0.053658832,0.0048112585,-0.0631949,0.053405542,0.029735912,0.009609836,-0.02587009,-0.013875632,-0.0348913,0.015622236,0.016663203,0.077284366,-0.035367575,-0.020072758,-0.0523028,-0.044417176,-0.009511417,-0.01574664,0.011576243,0.024855284,-0.042649467,0.019421918,-0.031714745,0.13928181,0.00044391264 +2.8.3.13,"Malonyl-CoA can also act as donor, but more slowly.",384,0.99999994,-0.061721604,-0.023917608,-0.010219714,0.03875766,0.014358564,-0.020779384,-0.025908595,0.07713258,0.049613275,-0.051998705,0.05220217,0.032537855,-0.07567071,0.056503363,-0.021905737,-0.00080333615,0.03419365,0.028367912,-0.030694555,0.08615334,0.015832826,0.0014185604,0.021731999,-0.03842745,0.06427755,0.020233143,-0.044059664,0.012300921,0.093430616,-0.080192626,-0.031297654,0.046048112,-0.043894667,-0.010021674,-0.020967811,0.087273024,0.0016354473,0.059695892,-0.034484964,-0.016608244,0.08648134,-0.13821211,-0.02011993,0.04714262,-0.11512992,-0.12157615,-0.041392088,-0.01532575,0.02724038,0.004305652,-0.05694055,-0.04708766,-0.07720815,0.0894139,-0.027042756,0.0028445784,-0.04294271,0.015915949,-0.03822468,-0.013079842,-0.0436797,0.105591916,-0.0018265552,0.026955156,0.071360216,0.03751729,0.07135856,-0.010118929,0.033616748,-0.037280075,0.06210778,-0.031942166,0.02781194,0.07101547,0.03641426,0.040356006,-0.01864852,-0.044708073,0.0060115396,0.06287165,-0.05531337,0.09229824,0.023915563,0.033450197,-0.055502694,-0.018911688,-0.051283814,-0.04797899,-0.09688973,0.018236702,-0.004201757,0.068035476,0.06548608,-0.04506342,-0.008013754,0.06697486,0.018959608,-0.024165949,-0.0127582345,-0.0014832583,-0.10338737,0.054486886,-0.08546625,-0.021191739,-0.044867538,-0.026234688,-0.032748576,-0.06142399,0.016251113,-0.013947574,0.00018626056,-0.012640004,0.053859625,0.0186047,-0.022131965,0.10204204,-0.060230862,-0.013915253,0.0045515858,0.048938744,0.011072642,-0.01317639,0.013660621,-0.04645516,0.021405512,0.027477551,0.021091623,-2.1172686e-33,0.053302366,-0.020496093,0.01998493,0.09077776,-0.086919196,0.03617491,-0.012284712,0.0075117685,-0.06011435,-0.010007913,-0.071596734,-0.094835736,0.022311514,0.038594145,-0.07824726,-0.028896661,-0.020226847,-0.045545187,0.05187587,0.02449207,0.081308804,0.090320975,0.02776838,0.0083374465,0.012386125,-0.001670882,-0.04633568,0.073200755,0.08567504,0.019720286,-0.031514347,0.062406763,0.009123628,-0.02773635,-0.053911462,0.04988898,-0.017274668,-0.020076787,-0.020049796,0.036768895,0.06546021,0.026745277,-0.050318316,-0.02472832,0.080491155,-0.04303097,-0.07452044,-0.057952944,-0.069343396,0.031892255,0.053180415,-0.04102897,-0.058010053,0.02234806,-0.04074439,0.033593383,-0.03365984,0.02050398,-0.04387552,0.049562275,0.047985986,0.043020867,0.033314582,0.04587659,0.020358734,0.007715874,0.022921873,-0.08154843,-0.11974714,-0.008574325,-0.031649176,0.01966906,-0.04369259,0.0011872933,0.00013376652,-0.07446803,0.026068093,0.040197033,0.10589261,-0.009022888,0.033774026,-0.0291542,0.042403772,0.029593945,0.005937617,-0.004290529,-0.034779567,-0.059301883,-0.016991269,-0.07049562,0.072418295,-0.05384218,-0.029133257,-0.12693779,-0.030722063,-2.7236893e-34,0.095340565,-0.18511821,0.07011228,-0.006358218,0.017191496,0.04622837,0.07011915,-0.01501065,0.056637384,0.14040734,0.0735913,0.035272617,0.041661706,-0.038402636,-0.009240069,0.047303878,-0.004460927,-0.06413981,0.013975293,0.0037836982,-0.05465962,0.13331413,0.0031577975,0.002687827,0.027075347,-0.042045157,-0.05925423,0.04064772,-0.025231842,0.012662035,0.048172243,0.017429171,-0.08363373,-0.08507042,-0.028056948,0.07906171,-0.036473986,-0.02720976,-0.07017304,-0.11916091,-0.05647009,-0.021708852,0.043955572,0.009986302,0.027722603,-0.014563681,-0.03871373,-0.05867457,0.06438575,0.032662854,0.008952279,0.049437027,-0.046053737,0.06500258,-0.0102413595,-0.009959155,-0.0034178493,-0.070148736,-0.018110337,-0.038111348,-0.066489846,-0.00025818736,-0.02067459,-0.0015144025,0.102707684,0.058745544,0.003952514,-0.0065823738,0.06679645,-0.023322761,0.123148546,-0.04039363,0.011872823,0.009209161,-0.02066466,-0.057550874,-0.03369515,0.008793157,-0.02596415,-0.019653106,-0.039251614,-0.027174074,-0.004090465,-0.036393918,-0.017795013,-0.052396763,0.036955953,0.034092177,-0.003296755,0.069997385,-0.065018296,-0.07561726,0.051328894,0.013565628,0.09455057,-2.1978554e-08,0.05775298,-0.0022877513,-0.020513255,0.019702902,0.033199254,-0.020975605,-0.06150937,0.04332468,0.012871824,0.07666894,-0.055904273,0.11343231,0.054364793,0.059291728,0.041026507,-0.01955859,0.02095049,-0.015324513,-0.058234885,-0.12581308,-0.09885846,-0.0038118835,-0.03447407,0.036149893,-0.013564322,-0.029680986,0.070064984,0.0002425968,0.018691337,-0.0716719,-0.0241677,0.0021745292,-0.029869804,0.043917865,-0.009844534,0.054640405,0.056973062,-0.009855468,0.019441787,0.074830234,0.056370538,-0.016063271,-0.03586438,0.016878402,-0.0068390975,-0.024102287,-0.01943106,-0.03259434,-0.0018174958,-0.051236693,0.057182785,0.03443101,-0.09109109,-0.016019873,-0.027210914,0.049641952,-0.00030763258,0.031455744,0.09037312,-0.05767171,-0.0049519935,-0.047034733,0.1230234,-0.023035329 +2.8.3.14,"Propanoyl-CoA, acetyl-CoA, butanoyl-CoA and some other acyl-CoAs can act as substrates, but more slowly than 5-hydroxypentanoyl-CoA.",384,1.0,-0.07863407,-0.14069995,0.004548805,-0.007844029,0.057607856,0.04319538,-0.101289324,0.013030788,-0.020856064,-0.030787889,0.094675496,-0.07905425,-0.06658479,0.07182757,-0.009715514,0.059316132,0.03947507,-0.0024600083,0.04081261,0.05265243,-0.0037589953,0.0024280995,-0.044045515,0.023451295,0.052188326,0.029177397,-0.018302156,0.010488343,0.068453446,-0.10711513,-0.045873366,0.05860533,-0.0055589224,-0.028695202,0.022138726,0.026890162,-0.060915865,-0.03895153,0.07501588,0.062138803,0.07078144,-0.12917617,-0.0062367846,0.0032574346,0.0142927095,-0.11620957,0.01265918,0.023539549,0.03565505,-0.0234568,-0.007744537,-0.0012697959,-0.117806956,0.023678081,-0.03686782,-0.08184991,-0.0037767952,-0.008991704,0.012416611,0.0668786,0.02852373,0.003541817,-0.07472531,-0.00020420986,-0.055733364,0.03306689,-0.026330214,0.009667449,0.05874853,0.040981665,-0.05718638,-0.055279512,0.039199278,0.06999616,0.012553964,-0.016155815,0.028892653,-0.05550592,0.041423492,-0.052302323,-0.048638795,0.037629608,-0.032834027,0.07478272,0.026436664,-0.00985356,-0.02673956,-0.0026614675,-0.063792795,-0.018943865,0.004362967,0.060965676,0.0023011798,-0.02500907,-0.07180202,0.039489288,0.06625068,-0.036401708,0.0015529961,0.010866926,-0.01802846,0.054931473,-0.08958833,-0.04844712,-0.072807275,-0.033304814,-0.032875977,0.006789657,-0.0065765143,-0.007755578,-0.07898109,-0.035179902,-0.040015813,-0.021586575,-0.06840043,-0.037785355,-0.03194957,-0.045307953,0.018733568,0.039556637,-0.03822978,0.044409942,0.01543397,0.06247045,-0.006858175,0.004314282,0.061859265,1.6365747e-33,0.05018882,0.014838851,0.017493365,0.015581049,-0.03257647,-0.04564402,-0.043826614,0.038644936,-0.019391602,-0.049499333,0.061295446,0.00559254,-0.04366068,0.10033365,0.028131083,-0.071667835,-0.010641547,0.03231924,0.046189312,-0.010858512,-0.08477242,0.027705736,-0.0408117,-0.038232017,-0.0020772251,-0.050766945,-0.06984693,0.05318491,0.025544478,0.0145949405,-0.053034376,-0.0117696365,0.017889392,-0.0064474726,0.019072765,-0.02903684,-0.045122873,-0.04714712,-0.010250599,0.04147756,0.021631727,0.047370907,-0.04925455,-0.00018595946,0.026973573,0.00569175,-0.010337803,0.089380406,-0.045292653,-0.014950983,0.051719524,-0.008520683,0.029824898,-0.05363083,0.018779319,0.025694627,-0.05016737,-0.009988188,-0.013368127,0.02937098,-0.009905233,0.08533746,-0.03799804,0.058898605,-0.022959374,0.059417143,-0.07907637,-0.008702557,0.011527599,0.010240317,0.0074776076,0.056025516,0.05238004,0.036080044,0.06975208,0.006261014,0.0010498406,0.017755914,0.042426888,0.010721941,0.000372274,-0.034908425,0.007773731,-0.043327983,-0.06588458,0.037690427,0.05339045,-0.06269928,0.02109934,0.015309009,0.010564276,-0.08741001,0.03277049,-0.034872722,0.010683749,-3.3958474e-33,0.0805794,-0.12979662,0.017775252,-0.07392536,-0.06661104,0.037900317,0.046118207,-0.073851325,0.013454806,0.071606256,0.097454816,0.047544595,0.023545442,-0.057715748,-0.009168498,0.074342646,0.044266563,0.03862566,0.057020277,-0.015441949,0.055004917,-0.0023696835,0.017065763,0.10062991,0.035860244,-0.000794559,-0.012235201,-0.047142807,-0.0049090376,0.109879576,-0.017760828,-0.05098613,0.021135237,-0.019084468,0.011416049,0.08401128,-0.04429343,0.068887904,-0.1060662,-0.04515375,-0.021822516,-0.008885204,0.009722241,-0.0048304703,-0.011706388,-0.04144373,-0.07587089,-0.022692239,-0.012670614,-0.0124452375,0.028179066,0.008099156,-0.06503701,-0.05029892,-0.037148193,0.05865465,-0.036733467,-0.03139848,0.06266122,-0.071745664,-0.021526214,-0.039797183,-0.039404627,-0.0964149,0.118126646,0.0449212,-0.016420323,-0.005166778,0.021285394,-0.01678023,0.091553934,0.07733139,0.080706246,-0.0012003889,-0.02492073,-0.049612645,0.040611465,-0.07239832,-0.13100646,0.03354612,0.0099167675,-0.00012512927,-0.039721113,-0.025483567,-0.12583391,-0.012858205,0.018962124,0.011865031,0.036872715,0.12336855,0.006467636,0.055160403,0.011476431,0.084017664,0.047442526,-3.275293e-08,0.06383023,-0.03865661,0.10920006,-0.014933945,-0.032441035,0.013092226,0.019877873,-0.063959196,0.09579218,-0.03981223,-0.008894098,0.0862386,0.08422853,0.051662598,0.05900064,-0.051818192,0.015707524,-0.023032794,-0.015538122,-0.048928056,-0.0829638,0.0005793448,0.034744557,-0.010128058,-0.023260724,-0.06998563,0.052964468,0.040235084,0.016029842,0.00086337305,0.0229748,0.0005292821,-0.07872901,0.00015769477,0.055040326,0.049873754,0.04444324,-0.06557213,-0.10409163,0.14648755,-0.03564618,-0.054852128,-0.073876396,0.041767087,0.10151662,-0.043366116,-0.046324104,0.04188906,0.047029447,-0.016039312,0.02236534,0.008181278,-0.062237754,-0.05753059,-0.014880886,-0.0051242714,0.0027657521,-0.007852065,-0.07296949,-0.030484881,-0.0300193,0.043405976,0.22275054,0.049314328 +2.8.3.15,Involved in anaerobic catabolism of toluene and is a strictly toluene-induced enzyme that catalyses the reversible regio- and enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA. The enzyme from Thauera aromatica is inactive when (R)-benzylsuccinate is replaced by (S)-benzylsuccinate.,384,1.0,-0.058749255,-0.040703367,-0.09744099,0.048253186,0.09594495,0.110747874,-0.07866869,0.002885493,0.032752987,0.019640971,-0.046450518,-0.04323869,-0.013309277,0.04946269,-0.09262696,0.022290198,0.0062031294,-0.003974404,-0.0039893207,-0.06216601,-0.024403132,-0.0405012,-0.008342448,0.02797802,0.101706214,-0.043597277,0.0044966065,-0.047462903,-0.103543624,-0.023583777,0.01893136,0.02097127,0.043914046,-0.06469784,-0.0034626967,0.1042603,-0.029070446,-0.020115573,0.073780596,0.017321758,-0.025072353,-0.04029582,-0.04574954,-0.04991148,0.00029133682,-0.021430753,-0.008160594,0.0033687588,0.012917962,-0.027555466,0.024422213,-0.0034502887,-0.032134797,-0.0048145796,-0.05185393,0.021002764,0.009236924,0.014795997,-0.1070767,-0.0003267707,0.039144088,-0.052438486,-0.03349959,0.03825884,-0.0014131527,-0.09322959,0.021416713,-0.04074796,0.053674985,0.016724344,-0.098860405,-0.03831825,-0.045657177,0.0018937043,0.04861028,-0.0023015786,0.047878575,0.026132267,0.057718392,-0.10380379,0.048511215,0.0034233849,-0.005673377,0.062419128,0.063460164,0.020892683,0.008092882,-0.04648845,0.12458036,0.045718595,0.064343035,0.075838506,0.0465565,-0.009170203,-0.14188755,0.0022930787,0.022674778,0.060116984,0.019873492,-0.015407403,0.063989125,0.009270897,-0.024491383,-0.057982467,-0.05762105,-0.04441668,-0.008611916,0.061167337,0.0895083,-0.027106414,0.025132814,0.027631093,0.08094478,0.008957978,-0.02087832,0.0970926,0.06820838,-0.061704025,-0.07534708,0.03917129,-0.041858412,-0.026070418,0.022428023,0.035389274,-0.034764297,-0.055969495,-0.059934735,3.209852e-33,0.116700046,0.041494183,0.04431242,0.0662558,-0.03645159,-0.029957065,-0.05172817,0.039457973,-0.020488624,0.0077478974,-0.04778643,-0.041404925,0.02262905,-0.0069025643,-0.010409085,-0.07090207,0.0043267757,0.0036899962,0.021872057,-0.0091302125,-0.09091189,0.09973936,-0.024056507,-0.0071952995,0.07123509,0.025682004,0.02167692,-0.012602703,0.0056117554,0.025994381,0.01768659,-0.0683194,-0.099840544,0.03529141,-0.047921162,-0.051685978,-0.029669363,0.033545587,0.02209411,0.06223102,0.061754394,0.066204555,-0.019662417,-0.01852313,0.010750462,0.007552295,-0.00065136846,0.105649084,0.05518172,0.052882325,0.058166683,-0.027953623,0.12631883,-0.0740335,-0.06250685,0.11258751,-0.009505363,0.040473297,0.06988236,0.045586787,0.020342737,0.06679964,-0.03888935,0.047700595,-1.0561935e-05,-0.014597318,-0.057641435,-0.048905134,-0.028044734,0.041842114,-0.07763369,0.003826853,0.021806998,0.08890672,0.036482707,-0.054795556,-0.051173534,-0.0030947765,0.033202533,-0.006877643,0.013354795,-0.024821302,-0.004070645,-0.022134347,-0.052872557,-0.002575073,0.014670841,-0.039415937,-0.016676428,0.055714756,0.061780553,-0.02705241,-0.019594992,-0.038267635,0.10963515,-3.189893e-33,0.12938215,-0.0815829,-0.067990094,-0.09551119,-0.03790451,0.02474266,-0.0047340733,-0.026353491,-0.015901037,0.02218214,0.10750522,-0.047042776,0.0218301,-0.009730284,-0.0045827506,-0.05000323,0.062288556,0.0179039,-0.07843973,-0.03204254,-0.07385402,0.014824416,0.026764357,-0.06388713,-0.020335007,0.052313767,-0.052009773,0.10823282,0.022545706,0.02188761,0.015253464,-0.037515823,-0.01069652,-0.032682408,-0.01448424,0.05935144,-0.047885958,0.044314962,-0.067545444,0.052418057,-0.06576067,-0.0012363105,0.015774993,0.05699234,0.025663543,-0.06775214,-0.1352908,-0.06069528,-0.01744833,-0.0746339,0.012158012,-0.04721802,-0.0034527802,-0.007823043,0.062157948,0.039780926,-0.034243375,-0.060504656,-0.0219214,-0.027188828,-0.027127584,0.04917074,-0.0017815664,-0.06443888,0.038569637,0.08960838,-0.09034858,0.056265485,0.045819666,-0.05113279,0.11136536,0.004540736,0.04633294,0.039341945,-0.06877508,-0.053589407,0.017419066,-0.033210676,-0.014579917,-0.06407061,-0.034562796,-0.042129226,-0.016118998,-0.031202596,-0.08855089,-0.10593354,0.0033689209,0.042224277,-0.007378441,0.0143484045,0.025306063,-0.019076822,0.011759658,0.093419455,0.07255194,-3.841883e-08,-0.0074427966,-0.09305913,0.037562612,0.012346126,-0.012909141,0.021963917,0.04415728,-0.07593497,0.041149702,-0.07546487,-0.009283396,0.036755633,0.10470575,0.024463817,0.054856863,0.033164196,-0.010585383,0.04347866,-0.05671279,0.017007524,-0.0536932,-0.008507917,-0.12307879,-0.008513326,0.08503352,0.004713247,0.019828903,-0.01008709,0.02384676,-0.016715856,-0.0054888767,0.007790518,0.013331271,0.082423784,-0.037695218,-0.008812878,-0.041659955,-0.05029553,-0.045901444,0.011747597,0.03732938,0.049931534,-0.07521007,0.076858126,0.035653934,-0.04566316,-0.007485827,0.016722815,0.024645677,0.011642157,-0.046042677,0.01946342,-0.049605343,0.0008100614,-0.05185002,0.046304896,0.014275258,0.018165631,-0.050336085,-0.04948226,0.032608807,0.020354273,0.1477555,-0.05870167 +2.8.3.16,The enzyme from Oxalobacter formigenes can also catalyse the transfer of CoA from formyl-CoA to succinate.,384,0.99999994,-0.12604074,-0.041865956,-0.116330676,0.061125834,0.05869451,0.047962278,-0.10746877,0.03413688,-0.0070345956,-0.042781193,0.04177114,-0.031548467,0.028619496,-0.0033534185,-0.009459836,0.033125374,-0.018351588,0.017125301,0.019260736,-0.011485336,0.05444549,0.007971539,-0.07035367,-0.028353913,0.08260165,0.032769285,0.020774655,-0.031580575,-0.0031570727,-0.08209773,-0.0035742044,-0.02935945,0.018122323,-0.0649108,0.030320197,0.04206657,-0.015284419,-0.040823605,0.09840531,-0.027623199,0.026920015,-0.038548786,-0.026579333,0.030951785,-0.07239448,-0.08930089,0.038882755,-0.026908249,0.017092485,-0.05775595,-0.11343434,-0.021967364,-0.07838673,0.042697072,-0.049210485,0.03979881,0.010837322,-0.05969166,0.0024491767,-0.009699433,-0.044910133,-0.0040293075,-0.032950025,0.047434784,-0.011309839,-0.07899772,0.019330857,0.01882974,-0.009177771,-0.040410586,-0.049501423,-0.0063384483,-0.010509177,0.052993022,0.0357879,0.012838665,0.01322299,-0.045149922,-0.0039291745,0.06931031,-0.021830274,0.0683611,-0.04894401,0.068789095,-0.01358991,0.0054760473,0.05008134,-0.04031561,0.03289576,0.014486598,0.026989985,0.015483288,0.005455947,-0.0028119164,-0.13309321,0.07474056,0.027466848,0.035633437,0.087733455,-0.007891067,-0.027875666,0.046616923,-0.054651834,-0.05579792,-0.024479138,-0.026422678,0.017528722,0.06398215,0.047544498,0.058720607,0.013339972,-0.06324745,-0.0001231406,0.02496259,0.024987996,0.08732036,0.023238242,-0.013234356,-0.15349402,-0.02865077,-0.0032872758,-0.008149372,0.073000334,2.872991e-05,0.006068827,0.029855167,-0.0789994,7.151143e-34,0.07863695,0.02886367,0.018210042,0.004956268,-0.028809318,-0.049553305,-0.089382164,0.077058114,0.002092358,0.028252816,-0.07145768,-0.06361498,0.030620828,0.012507414,-0.038845614,-0.049839698,-0.025623288,-0.0060267956,0.016646052,0.06244564,0.028561229,-0.016434548,0.05188014,0.00488024,-0.0073847757,-0.008152259,-0.011447524,0.07007191,0.015527875,0.0041254275,0.060047902,-0.08585361,-0.10395785,8.552182e-05,0.022321204,-0.050483905,-0.082264625,-0.05523588,0.008393755,0.045975182,0.040997017,0.03735777,-0.036401443,0.01172008,0.045187525,-0.008359239,-0.013781517,0.09343266,0.056586325,0.07514235,0.02389993,-0.044115666,0.08089251,-0.032292884,-0.00019373004,0.041506555,-0.024152832,0.040267743,0.049686164,-0.02201441,-0.019285847,0.03399026,-0.007982912,0.004296257,-0.009717012,0.012522479,-0.10332332,0.0071179513,0.04740161,0.024748834,-0.041877143,0.0018311009,-0.0774678,0.034345645,0.028622095,-0.047258243,-0.03684333,0.030862212,0.10157178,0.03539724,0.026008036,-0.0130784325,0.00029841464,-0.034970645,0.04556991,0.006280592,-0.04500202,-0.039248887,-0.0454888,0.050606374,0.08573562,-0.025698412,0.0077751763,-0.050655663,0.03104162,-2.136958e-33,0.11764682,-0.14811082,0.020642364,-0.12639245,-0.028909346,-0.023246733,-0.003870452,-0.010324298,-0.0077591063,0.026086528,0.019177709,0.05675227,0.0434636,-0.04368622,0.01717183,-0.034933608,0.054167822,0.024483837,-0.020510478,-0.01407574,-0.043824594,0.08968849,0.02332732,-0.072158426,0.06422648,-0.0036983367,-0.008385339,0.0580088,0.0038605887,0.08657933,0.0146644665,-0.00690042,-0.028207008,0.0038904194,-0.045733564,0.055356972,-0.020695655,0.03237087,0.03825755,0.024237255,-0.08257827,0.002135647,0.03887983,0.0002878132,0.005568683,-0.024882114,-0.0656562,-0.028017687,0.0134946685,-0.004766865,0.06517259,-0.0033294703,-0.08462882,-0.041238844,0.004247064,0.03287864,0.010648059,-0.02476093,0.057469018,-0.12592699,-0.04353915,-0.025939284,0.008739022,-0.06537079,0.08233094,0.093046196,0.041786887,0.021175245,0.031010246,-0.052498043,0.096944414,0.0042646113,0.038094647,-0.036077682,0.021173064,-0.029946554,-0.035584323,-0.026932871,-0.061634414,-0.013887468,-0.048705187,-0.05027775,-0.030028772,-0.074751474,-0.046761725,-0.04632473,0.026561333,-0.005663421,-0.046836622,0.03896773,-0.08860136,0.020477314,0.07850534,0.06444187,0.07689886,-2.3490866e-08,-0.04681601,-0.052482348,0.047166485,0.04649194,0.071815036,0.046123624,-0.12035727,-0.07913141,0.07783348,0.032855105,-0.01446,0.12095542,0.056183293,0.031813107,0.04908228,-0.058341708,0.0018695708,0.013358139,-0.05444245,-0.061409388,-0.06465096,-0.021227024,-0.060489357,0.13216221,0.07002217,-0.072589375,0.016783554,-0.028186377,0.03281724,-0.049134474,0.007422426,0.02799524,0.03965755,0.004708218,0.004628927,-0.03040184,0.039172165,-0.04314136,-0.0134200705,0.07672158,0.08434642,0.027335858,-0.11128695,0.044078544,-0.018939199,0.026568906,-0.02594272,0.07775014,-0.06360995,-0.005390655,0.0651458,-0.03483957,-0.04105235,0.021571515,-0.04950276,0.006783921,0.022911439,-0.020386739,-0.030768953,0.06438395,-0.012450571,0.045848,0.24288449,-0.055788603 +2.8.3.17,"The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It forms a complex with EC 4.2.1.175, (R)-3-(aryl)lactoyl-CoA dehydratase.",384,0.99999994,-0.051634986,-0.04423734,-0.10865073,-0.034071874,0.12112513,0.058966618,-0.041084465,-0.007969704,0.03321043,0.007178908,0.019299557,-0.117560156,-0.057255402,0.08957295,-0.03306518,0.0032794573,-0.085666575,-0.048065104,0.017582653,-0.053878568,0.057431333,0.07196843,-0.021600084,0.03448793,0.054787308,-0.012597438,0.07236033,0.0031105767,-0.06285137,-0.03952474,-0.0028331445,-0.060970284,0.12147814,-0.027291475,0.05894007,0.096754454,-0.01833746,-0.05226799,0.125967,0.033486806,0.02402386,0.00060484256,0.025754616,-0.038180187,-0.0024631412,0.028978245,0.036651284,0.0071306163,0.040007897,-0.026282987,-0.059760604,-0.04952137,0.014904228,0.0069102366,0.05209571,0.025111718,-0.00014120298,-0.02731003,-0.060609255,0.041106094,0.100306526,-0.009995197,0.045847483,-0.01308262,-0.02327381,-0.044443358,0.029529892,-0.06671332,0.053973757,-0.076790586,-0.06777362,-0.08410684,-0.031553753,0.014609201,0.006189637,-0.025599957,0.029807808,-0.054917637,0.0072366036,-0.052662037,-0.007523636,-0.007802695,-0.016301528,0.0508272,0.007327886,-0.062105358,0.036046647,-0.0076905126,0.08340145,-0.006316625,-0.0018195309,-0.012633012,-0.035797205,-0.071197286,-0.03741795,0.002167994,-0.010365302,-0.0086877225,0.037052087,-0.031458504,0.003114341,0.07135848,-0.036467172,-0.09687559,-0.006789981,0.00421632,0.08293043,0.10833239,0.027873376,-0.008875135,0.010897301,0.005438344,0.085995205,0.025941923,0.012587382,0.07644878,0.034990422,-0.04218683,-0.04805908,0.057195563,-0.000846435,-0.024036271,0.10231969,0.09521876,-0.018552406,0.04262481,-0.07987489,-2.269415e-34,0.08189126,-0.012531755,-0.0028074526,0.012791356,0.054658614,-0.00034986105,-0.086108305,0.026992107,0.044637427,-0.044159874,-0.056653652,-0.083883874,0.040078558,0.0408508,-0.04314316,0.0046285954,-0.08411785,-0.021167913,-0.0114971455,0.07876763,-0.024810633,0.047001462,0.003805056,0.0103347525,0.037728064,0.06031191,0.0634517,-0.014953721,0.029288549,-0.0011397087,0.017821591,-0.11867869,-0.13471593,0.002929435,0.027689092,0.0073670056,-0.061347958,-0.0026585108,-0.028329346,0.06404231,-0.014135616,0.09430014,0.018951302,0.008297669,0.004868854,0.040619537,-0.00021923066,0.12331134,0.051360857,0.026436726,0.033386525,-0.0575656,0.06581128,-0.07878582,-0.0377189,0.0162824,-0.046326753,0.06142468,0.061469812,0.044799846,0.041177213,0.041704286,-0.043590426,0.09399921,0.033211518,0.014471408,-0.027690625,-0.057334673,0.07415915,0.030362127,-0.09696948,-0.07003849,0.079647414,0.0063282037,0.031667978,-0.05000936,-0.11616581,-0.08668935,-0.013067749,-0.009959317,-0.020539748,-0.098209105,0.049548637,-0.06805032,-0.056430537,-0.012031337,-0.015270074,-0.053583667,0.024561066,-0.022626223,-0.0036037492,-0.021134498,-0.04843886,0.02940987,0.032358997,-9.873005e-34,0.09498332,-0.13609667,0.019499512,-0.10244061,-0.07096364,0.05170557,0.010956214,-0.030150712,-0.001459368,-0.009809165,0.12231778,-0.05038756,0.017455542,-0.041806,0.06719603,0.0056446665,0.008096397,0.05907492,0.0034515136,-0.00978219,-0.027823333,0.022287192,0.02987433,-0.045584664,0.07810589,0.0713203,-0.05979804,0.08762269,0.015456641,0.011119413,-0.011185432,-0.011858874,-0.03570594,-0.050053928,-0.03576014,0.060572628,-0.07354546,-0.038068384,0.021621794,-0.0021983024,0.036536675,0.025979338,-0.007368028,0.02903309,-0.019922767,0.04696264,-0.049392443,0.015576583,-0.023461904,-0.07100442,0.017147046,-0.09564039,-0.01326206,-0.059866376,0.009786258,0.06958842,-0.033434335,0.046396602,-0.03697632,-0.0005574419,-0.055904817,-0.03631302,0.08883552,0.021611935,-0.006051536,0.02769764,-0.020492276,0.04791332,0.074474044,0.004821431,0.08811942,0.010374164,0.061272867,0.1049745,-0.09071023,-0.017791372,-0.058957286,-0.018669015,0.008000279,-0.042726934,-0.0009111109,-0.036215972,-0.033487834,-0.002177564,-0.027546706,-0.07927523,0.01399023,0.097442955,0.020764582,0.05255515,-0.021938698,0.0024472042,-0.04756916,0.041680552,0.07345224,-3.7804927e-08,0.06490538,-0.09033662,0.044140734,-0.002582268,0.02431854,0.007335501,-0.02213903,-0.0018838026,0.032269754,-0.041232415,0.021543229,0.0762814,0.0145657845,-0.014527895,2.4202636e-05,0.017561553,-0.038485322,0.03566032,-0.03126084,0.015654868,-0.047932886,-0.06114224,-0.13862015,0.024862098,0.016699627,-0.028903253,-0.003787677,0.05649411,0.003223401,-0.09962315,0.008716962,0.02668245,0.019035209,-0.009230825,-0.06723974,0.034164168,-0.08679571,-0.039324615,-0.03345159,0.0019446615,0.020469733,-0.037994314,-0.057128444,-0.015790347,0.029592928,0.033910383,-0.017425079,0.020642657,-0.03289918,-0.025842953,-0.0062728915,0.022118859,0.0050242925,0.07680521,-0.08533227,0.032408077,-0.042845536,-0.0724342,0.019009184,-0.04132829,0.03536771,0.035288557,0.14228614,-0.07976667 +2.8.4.1,"This enzyme catalyses the final step in methanogenesis, the biological production of methane. This important anaerobic process is carried out only by methanogenic archaea. The enzyme can also function in reverse, for anaerobic oxidation of methane.The enzyme requires the hydroporphinoid nickel complex coenzyme F430. Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. The sulfide sulfur can be replaced by selenium but not by oxygen. ",384,1.0,-0.052370124,0.012074421,-0.060946435,-0.004144494,0.099053875,-0.03732361,-0.084341824,-0.004141335,-0.060441624,-0.021886311,-0.043819122,-0.10006485,-0.05355489,0.010070973,-0.0046188934,0.06945112,-0.03948888,-0.045162458,-0.013498635,-0.060688503,0.084745325,0.017701685,-0.018018277,-0.017705519,-0.038267445,-0.015317037,0.02813775,-0.008669577,-0.009463558,-0.05315324,0.008412564,-0.032993536,0.12598474,-0.035756666,0.028353574,0.08011701,-0.00064415974,0.012822277,0.03633098,-0.0027178298,-0.022412466,0.026546024,0.07922113,-0.021966802,0.02700426,-0.002709452,-0.0003917385,0.026866132,-0.012882291,-0.089230254,-0.03235869,-0.031102445,-0.061793137,0.025936851,0.035076346,0.07307367,-0.045736182,-0.067472436,-0.043672524,-0.07242123,0.10313239,0.009014007,0.009827338,-0.046715625,0.046110313,-0.011009711,0.0804574,-0.097421706,0.11727639,-0.011223017,-0.067961715,-0.030755209,-0.06719679,-0.030776521,-0.050083037,-0.008095497,0.020642184,-0.046152905,0.061478898,-0.0028282583,-0.007414885,0.02586211,0.050328854,0.003029271,0.06400055,-0.020749219,-0.018965313,-0.022475675,0.039779224,-0.032563828,-0.044180837,-0.01800902,-0.022224912,-0.008612416,-0.13284443,0.033098765,0.06498374,0.07232214,0.03568168,-0.01922105,0.0012206448,0.08927498,-0.064277194,-0.06506737,-0.07087408,-0.001463679,0.07304603,0.12807156,0.04338573,0.0335341,0.03633253,0.016015926,0.10095271,0.015064843,0.0241893,0.09743093,-0.004487581,-0.035431825,-0.034622055,0.110506944,0.019032532,0.033393625,0.019166412,0.051221397,-0.059519477,-0.013086778,-0.050009828,6.249503e-33,0.055638995,0.01819197,-0.04372286,0.023791865,-0.018923275,0.0075070383,-0.06990764,0.019097185,-0.028888207,-0.00052597414,-0.05304884,-0.043540895,0.05710517,0.026927177,-0.07164617,-0.03289314,-0.009306527,-0.017330216,0.033677988,0.033420432,-0.047267288,0.015333288,-0.038283274,-0.041665386,0.062227003,0.028330293,0.060094103,0.0052266484,0.059619144,-0.0058114035,0.04241644,-0.06452194,-0.093981676,0.02933894,0.049380586,0.04812446,-0.094234146,0.05520959,-0.08056696,0.07147561,-0.024973609,0.07329302,-0.03255683,-0.043523736,0.029661363,-0.017758194,0.002841127,0.1495313,0.08974893,-0.021220332,0.0064875684,-0.009331778,0.020713292,-0.06136998,-0.022210604,0.01651724,0.054092344,-0.04209882,0.02900362,0.038774848,-0.003081578,0.013711691,-0.083429694,0.11734765,-0.041016527,-0.005369859,-0.012073273,-0.004581256,0.04760566,0.09587981,-0.08250155,-0.020216102,0.011165563,0.073230244,-0.015143521,-0.05819586,0.008191553,-0.10122154,0.05989316,0.016024426,0.03735314,-0.0635962,0.020059058,-0.052147165,-0.048379064,-0.055958733,-0.049744856,0.004492724,0.070697926,0.066207476,-0.0007543195,-0.07669855,0.0025572,0.0017089321,0.054785933,-4.8897736e-33,0.06300301,-0.05074777,-0.056123763,-0.1110338,-0.059997316,0.07988802,0.020830385,-0.08918448,0.056711283,-0.0039584436,0.085314214,-0.033017613,0.0308164,-0.018125033,0.043087374,0.02765077,0.0009774051,0.075268745,0.008926314,-0.008191527,-0.0055009252,0.09859803,-0.06695545,-0.04012671,0.011465058,0.05144474,-0.02257395,0.075149864,0.047371443,0.038249277,-0.037445337,-0.060056776,-0.023782885,0.00023609269,-0.03358171,0.06005352,-0.068856396,-0.005061874,0.008883991,-0.038025465,-0.0048634233,0.06607378,-0.034736548,0.043728437,0.029507136,0.020603795,-0.13537148,-0.059180547,0.021025533,-0.037422407,0.051373146,-0.091227084,-0.058040414,-0.057106763,0.005501057,0.054585185,0.0108453445,0.027433498,-0.011785931,-0.023853015,-0.033907626,-0.031387866,0.08952019,0.010351778,0.030273603,0.057974715,-0.053360675,0.08359517,0.012017867,0.03587378,-0.000827125,0.058219504,0.062972054,0.043079983,-0.028203785,-0.048650492,-0.044251777,0.02768617,-0.022258839,-0.010730247,0.033429813,0.00042754482,0.07498659,-0.04728561,-0.0227184,-0.09038561,0.007070215,0.06317554,0.01871225,0.03388887,-0.018456293,-0.00719651,-0.035100862,0.015924802,0.077320285,-3.635587e-08,-0.02739781,-0.0694473,0.05358032,0.036668535,-0.008645343,0.105785646,0.08642183,-0.061343096,0.044121884,-0.004381548,-0.03245927,0.067915425,0.0833958,-0.0031866757,-0.020874895,-0.011606428,-0.015131013,-0.04034196,-0.040857207,-0.02591493,-0.06960142,-0.005091564,-0.048720457,0.025715064,0.011650735,-0.036049176,0.03710533,0.066072956,0.002380247,-0.043502502,-0.05183729,0.011546944,-0.0128343925,0.015149249,-0.07692103,0.0043268446,0.01325677,-0.02425285,-0.0612012,0.0010718046,0.026178295,0.020045161,-0.07890886,0.0042989478,0.11004887,-0.0898515,-0.057772975,-0.0064447117,-0.026864884,0.065280646,0.051406153,-0.06083264,0.014045403,0.02753511,-0.04408119,0.0029134233,-0.017477185,-0.010374176,-0.056379866,0.0028705245,0.043312278,0.00497257,0.18081757,-0.11080659 +2.9.1.1,"A pyridoxal 5'-phosphate enzyme identified in Escherichia coli. Recognises specifically tRNASec-species. Binding of tRNASec also occurs in the absence of the seryl group. 2-Aminoacryloyl-tRNA, bound to the enzyme as an imine with the pyridoxal phosphate, is an intermediate in the reaction. Since the selenium atom replaces oxygen in serine, the product may also be referred to as L-selenoseryl-tRNASec. The symbol Sel has also been used for selenocysteine but Sec is preferred.",384,1.0,-0.06267729,-0.11235977,-0.06927849,-0.02334849,0.019028999,-0.040563088,-0.002789819,0.043983947,0.077017665,-0.0838504,0.0846372,-0.0057538343,-0.036322877,0.03974949,-0.06126071,0.052902285,-0.021889584,-0.034943145,-0.015922727,-0.04430517,0.09303153,0.07130012,-0.017229008,0.024772553,-0.0011145192,-0.032883193,0.043631755,-0.0154946195,-0.03388409,-0.048231576,-0.049295396,-0.03112288,0.07395912,-0.07446992,0.08963013,0.056174014,-0.078463554,-0.029236224,0.08445253,-0.0073982566,0.0013251844,-0.08064344,-0.08697143,-0.0020006327,-0.13631937,-0.07636503,0.04766289,0.01795653,-0.01927545,0.07416175,-0.044730227,-0.026975114,-0.1331756,-0.026964156,-0.034595713,0.02622184,-0.0124138,-0.015254404,-0.03589444,-0.019777242,0.04326202,0.024676109,0.009823316,-0.007923236,0.027703583,-0.052008137,0.04113688,-0.063608095,0.007060087,-0.013279281,-0.085096985,-0.07028585,0.08448325,0.089678906,-0.029328102,0.025599295,0.031146199,-0.052859005,0.025400884,0.010210715,-0.038067598,-0.05033512,-0.007444992,0.064567305,0.062210996,0.055345323,-0.011951717,0.022626981,0.05376329,0.027100898,0.084100924,0.0013747407,0.012755945,-0.036567498,0.023564454,0.06569457,0.029456275,0.029556114,-0.026116805,-0.03418433,-0.033100687,0.024022667,-0.03264953,-0.0358762,-0.06217,-0.028215934,-0.014916195,-0.016576685,-0.00470384,-0.09690486,-0.013963421,0.011719979,0.03668549,0.019611614,-0.03231861,0.068657115,0.069532365,0.015396994,0.068362355,0.0121151665,-0.011913881,-0.017419724,0.022410385,0.061577715,-0.014551699,0.08108786,-0.11305225,2.7330793e-33,0.056678332,0.051820498,0.02852673,0.034076348,-0.036217038,-0.028776128,-0.054485034,-0.029517246,-0.10908863,-0.0138623165,-0.07081114,-0.089266606,0.06596669,-0.014312162,-0.010944121,-0.020210225,-0.064409286,0.033537887,0.042390563,-0.02233483,0.039696403,0.070924655,0.0046410393,0.06399252,-0.03241649,0.05471052,-0.034674034,0.05400055,0.045257226,0.036316466,0.06263378,-0.041206833,-0.069235906,-0.030912215,0.11609012,0.008276679,-0.012617254,0.003192978,-0.07438622,0.02721199,-0.013490545,0.03437131,-0.009565813,0.031997595,-0.009389726,-0.11002844,-0.055321105,0.10601009,0.024909295,0.021087829,-0.018493418,-0.04221733,0.08401949,-0.05620604,-0.032745026,-0.022030065,-0.039154053,0.0018349912,0.064809,0.09313986,0.041694038,0.051288918,-0.029216325,0.039775733,0.031154318,0.036625683,-0.04796983,-0.065849945,0.006950613,0.07386657,-0.012718983,0.04034223,0.04660784,0.06861512,0.0518196,-0.06422544,-0.10029574,-0.0064974306,-0.020915799,0.019238533,0.03253011,-0.0625451,-0.006002458,-0.07269676,-0.06507488,-0.044058964,0.0032462971,-0.044481773,-0.044604428,0.060644817,0.050962105,-0.08203218,-0.0486385,0.009137344,-0.013778622,-3.939595e-33,0.049662203,-0.09773372,0.055999596,-0.036196966,-0.087776326,-0.01738739,0.043853227,-0.07033267,0.018647853,0.011556231,0.10061242,0.056184996,-0.049475778,-0.0048879976,0.018726261,0.022041082,0.0027740276,-0.07875902,0.024180256,-0.046592616,0.026139721,-0.008586831,-0.0054871337,0.06892049,0.066027865,0.010460733,0.033838898,0.015360842,-0.057643928,0.00023426987,-0.057681907,0.002247643,0.042452976,0.027670305,-0.11400235,0.03886409,-0.04979085,-0.039675478,0.044129428,0.001936661,-0.0053044036,0.063609175,0.059593,0.09671591,-0.023964776,0.011412355,-0.047648236,0.036842756,0.005258571,-0.050203133,0.057973303,0.0020699538,-0.0037114772,-0.074294895,0.05732411,0.08166726,-0.054719526,0.001750928,-0.071303666,0.009881919,-0.0025500257,-0.041753598,-0.01899504,0.044205815,0.08331998,0.004824223,-0.03712158,0.05797087,0.035183437,-0.013882539,0.047326155,-0.015882844,-0.009007636,-0.011324049,-0.012344494,-0.10776842,-0.0019257667,0.07295352,0.013226617,0.0030959705,-0.028420018,-0.015710598,0.023466604,-0.066459976,0.019781167,-0.067480795,-0.016749198,0.17072855,0.05522166,0.04716185,-0.018904487,-0.0024998437,0.020005804,0.078622,0.127635,-4.5798544e-08,0.014490056,-0.035767097,0.017400783,-0.05025105,0.07993185,0.05084909,0.0059446543,-0.028187823,0.088758826,0.018678283,-0.058879506,0.10394482,-0.013465934,0.009019239,0.010586912,0.05107994,-0.06878423,0.015965912,0.012946882,-0.03353512,-0.037252415,0.0303337,-0.15462133,0.017545704,0.08304004,-0.03956665,-0.046041925,0.030027624,-0.023446983,-0.015288731,0.017160084,-0.05463871,0.0128927035,-0.08800825,-0.06708436,0.05268616,-0.052552756,-0.03499388,-0.03250116,0.09427428,0.022356983,0.007248158,-0.038105775,-0.024367042,-0.0018844254,0.064827465,-0.05027064,0.010396664,-0.03280644,0.003212511,0.052270703,-0.054821625,-0.017966663,0.013296425,-0.08117868,0.022304744,0.0067344205,-0.05547268,0.008996251,-0.026356298,0.032594748,0.033512175,0.122607544,-0.006832773 +3.1.1.1,"Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.",384,0.99999994,-0.068854,-0.09551851,-0.06953375,-0.00789863,0.07208297,0.05168179,-0.02101389,0.0058050766,0.023045152,-0.021722017,0.04598525,-0.05039262,-0.10380606,0.0066365353,-0.007055691,0.033025127,-0.06768465,-0.0122174015,-0.004991887,-0.09498584,0.09660098,0.013760476,-0.060953286,-0.03409606,0.039917506,-0.031507056,0.039096788,-0.06123907,-0.0564807,-0.09808051,0.010641943,-0.056965206,0.035997216,-0.07409108,0.035219714,0.11368763,-0.04717134,-0.07120851,0.02233036,-0.0139774615,0.061226368,-0.058222968,-0.013368809,-0.066959776,-0.012862696,-0.025166739,0.036462598,0.0016772314,-0.028312963,0.04864641,-0.07164951,-0.06101054,-0.07025651,-0.04109953,-0.02028741,-0.057032585,-0.05002284,-0.021179458,-0.036598273,0.086658604,-0.017988428,-0.04357043,0.010316166,-0.010502334,-0.04703438,-0.070219435,0.0697074,-0.040932823,0.07656942,-0.0059080785,-0.07018197,-0.11302108,-0.06444836,0.018984642,0.030587904,0.02939582,-0.03448821,-0.057369962,0.015233946,-0.030077497,-0.044345908,-0.031100776,-0.0107098045,0.07825224,0.076955356,-0.01723034,0.026889054,0.012297292,0.031638645,0.07057557,-0.006860163,-0.029254748,0.0153362565,0.03005967,-0.014064223,0.04517216,-0.0016476997,-0.027035454,0.026274737,-0.053558618,-0.0183304,0.047121745,-0.03478329,-0.07461064,-0.026184486,0.048611034,0.026442023,0.07462176,0.051220603,-0.0019839308,0.00013114819,-0.031657636,0.042632673,-0.032189775,0.013452511,0.052389994,0.033027932,-0.07102402,-0.02736118,0.023670137,-0.010210681,0.016099984,0.10289723,0.0565374,-0.015265759,0.09092632,-0.072742954,1.7643371e-33,0.023636546,0.07852743,-0.02718667,0.011476189,-0.0034019337,0.075061336,-0.08680329,0.103498936,0.009664886,-0.06002524,0.019249974,-0.016319282,0.07512893,0.05610311,0.009477779,-0.028440705,0.10318053,-0.0074126814,0.062806435,-0.020107377,-0.030999687,0.0036655029,-0.057356715,0.04567397,-0.017234826,0.0046226857,-0.01675016,0.061198216,0.0393881,-0.031118918,-0.027321536,-0.093933105,-0.04290182,0.037076134,0.03652632,0.09032168,-0.014960353,-0.036817852,-0.027540252,0.0801967,-0.015261461,0.0048707556,-0.008891854,-0.08123926,-0.012105374,-0.01061347,-0.10067308,0.10080015,0.030963235,-0.025644014,0.009938109,-0.010355742,0.1869123,0.034513086,-0.017088838,0.06258206,-0.0957177,-0.008174201,0.016549718,0.0044510146,-0.0047587,0.061842706,-0.0073855342,0.0033841114,-0.071964204,0.05396156,-0.04233542,-0.0007936599,-0.058775652,0.052017443,-0.009242035,0.076064005,0.12952067,-0.03957064,0.06649366,-0.020052288,-0.07461015,0.016956402,0.0077335327,0.054800533,-0.012617497,0.028993152,0.054722022,0.03319282,-0.076202996,0.018393708,-0.03946524,0.014988116,0.059967067,0.054390546,-0.0283917,-0.07051608,0.010722399,0.033956803,-0.05153802,-2.0951312e-33,0.071895845,-0.08977969,0.014448199,-0.074158415,-0.0016469263,0.063933596,0.054220274,0.0082903765,0.019881936,-0.028340092,-0.0027585765,-0.02222716,0.0514171,-0.15017888,-0.001787455,0.005398272,0.017100811,0.077220626,0.08257805,-0.02191528,0.0071835886,0.04098509,0.037778486,0.08724711,0.076157294,0.009384107,-0.006831263,0.017243998,0.024744926,0.037790526,-0.005252289,-0.03955033,-0.02338974,-0.055320658,-0.0295701,0.065849885,-0.043059565,-5.333481e-05,0.018471643,0.019975677,0.04013451,-0.016476156,-0.0075521544,0.059620667,0.07327919,0.07759663,-0.048278853,0.039328497,-0.07564801,-0.04939118,-0.013596388,-0.0068901214,-0.02384427,0.006840397,0.033939432,0.050608084,0.057299342,0.010966639,0.06000026,-0.027802002,-0.034268003,-0.07296117,0.008888644,0.047648635,-0.0045399107,0.0860658,-0.054020602,0.057139978,-0.006555881,0.037717123,0.10900936,0.0038522442,-0.024831958,0.008151851,-0.0031928308,-0.017945431,-0.016082885,-0.110056505,0.009588289,-0.10890925,0.062389344,-0.014041631,0.008672503,-0.012520037,-0.06362489,0.009372848,0.02895114,0.11673171,-0.05097761,0.04015699,-0.04754005,-0.02970289,-0.040027536,0.056644138,0.056326345,-5.096146e-08,0.10520282,-0.014009149,0.050214987,-0.054159105,-0.0090011945,0.027776247,0.014768309,0.07228649,0.090525314,-0.031793963,-0.05980015,0.031765077,0.018005084,0.04344941,0.05001008,-0.025523543,0.013317937,0.039266683,-0.03911566,-0.010838613,-0.080056176,0.04251485,-0.11284542,0.008313578,-0.00953134,-0.08127517,0.0859834,0.04815031,-0.016139315,-0.03314483,-0.049306527,0.027280534,0.0019227524,0.009917888,-0.023859592,-0.0026529217,-0.006993126,-0.06800175,-0.029448813,0.04582954,-0.046945218,-0.05013458,-0.05178823,0.0041114157,0.023106217,-0.004909144,0.025798356,-0.023832796,0.011157253,0.027609196,0.020805703,0.026049655,0.007473438,-0.04615278,-0.059502695,-0.050921187,-0.0070415954,-0.09998488,0.008307201,-0.062001456,0.049791407,0.03546263,0.19075975,-0.017620757 +3.1.1.2,"Acts on many phenolic esters. The reactions of EC 3.1.8.1 aryldialkylphosphatase, were previously attributed to this enzyme. It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases [7,8]. The natural substrates of the paraoxonases are lactones [7,8], with (+/-)-5-hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate [8].",384,1.0,-0.06867337,-0.074990295,-0.042237673,-0.04072535,0.017779976,0.055169754,-0.046955988,0.053032734,-0.0058074384,-0.020527432,0.023920607,-0.06706101,-0.067264125,0.01864888,0.000752072,0.039949708,-0.098390855,-0.053120725,-0.0008944531,0.0094645405,0.07824597,0.029000575,-0.024584707,0.023757251,0.089485124,-0.011871777,0.057753317,0.02491626,-0.037339196,-0.020210817,-0.016087946,-0.09252742,0.0324109,-0.05023223,0.06796008,0.05824819,-0.039234135,-0.0622556,0.050253723,0.01835633,0.023138447,-0.015272825,-0.08555051,-0.038754784,-0.012865612,-0.05059788,0.02236699,-0.009076312,0.05070131,-0.022954721,-0.046254583,-0.03408634,-0.03476288,0.040158574,-0.012908925,-0.054321688,-0.030916533,0.04011235,-0.0078716045,0.014045829,-0.01359254,0.008405476,0.007303219,0.025595667,-0.060083725,-0.006882429,0.07033116,-0.041928094,-0.013013395,0.00858292,-0.072967194,-0.10725506,0.025904309,0.018359102,-0.056336198,0.0730461,0.060080852,-0.1232057,-0.022262625,-0.006802887,0.054729283,-0.0830627,-0.04401772,0.08030234,0.052964006,-0.009779579,-0.033037074,0.010186778,0.015717207,0.067149736,0.059300926,-0.03132951,-0.016172446,-0.014293768,-0.012091732,0.12051901,-0.047605544,0.048418608,0.045212477,-0.02236821,-0.0023859374,0.02670809,-0.022955753,-0.08430684,0.024001988,0.0812544,0.09661592,0.023328384,0.026637144,-0.0070221066,-0.034668334,-0.040549126,-0.019572774,-0.029217765,-0.0694934,0.11941609,0.024065733,-0.074640274,-0.02549097,-0.012723521,-0.0062401574,-0.0054072863,0.055343263,-0.0037234346,0.023599358,0.0007682101,-0.07762711,1.9276118e-33,0.09677447,0.08282875,0.044072162,-0.011855465,-0.015653256,0.056629185,-0.09487039,0.061959352,-0.020812623,-0.04972786,-0.04011854,-0.06626568,0.012783702,-0.00651067,-0.016034419,-0.032365825,-0.019483628,0.028169906,-0.028977856,-0.027219635,-0.018477378,-0.04731752,-0.061656542,0.04011543,-0.037902363,-0.017876869,-0.044211905,0.022878582,0.016425954,-0.008859461,-0.017621204,-0.06525041,-0.14013498,0.056177016,-0.01649826,0.056756,-0.018694876,-0.018291015,-0.02389494,0.030744791,-0.027133133,0.029824274,0.020434815,-0.03456645,0.009504495,-0.09947354,-0.111831985,0.07325987,0.08406731,0.04278869,0.013311076,-0.0771623,0.10049542,0.0016344247,0.014234421,0.023356894,-0.07108138,0.016363136,0.09811245,-0.008346947,0.07388294,0.0022222511,-0.0025479775,0.015781768,0.06283427,0.07637182,-0.031528145,-0.019555418,-0.054585148,0.03386769,-0.03456606,-0.024266867,-0.0037540433,0.026828915,0.06424517,-0.01219244,-0.054552406,0.005934557,0.025305873,0.04280272,0.0033889918,-0.074644715,-0.023299795,0.024018925,-0.037527267,0.031310324,-0.02078126,0.007207357,0.080368444,0.055350017,0.068777636,-0.048839048,-0.0599551,0.017824173,-0.09208191,-2.3734664e-33,0.052179154,-0.07879198,0.0400775,-0.1052797,-0.0025014668,0.057662103,0.034741536,0.0627531,0.007718856,0.044641875,0.085233666,-0.044016548,0.09808498,-0.10071891,-0.023514422,0.0141533045,-0.00980655,0.029941726,0.0966916,-0.04953785,0.03735243,0.06799909,-0.06289223,0.0849458,0.0022214246,-0.023115287,-0.051010694,0.03921217,0.073768124,0.024189252,-0.04554679,0.017981209,-0.01692865,0.04055274,0.037713643,0.12071782,-0.03070974,0.03798266,0.03411087,0.038060993,0.001041997,0.01746901,0.04217644,0.051779903,0.026920715,0.11193019,-0.041058958,-0.061678477,-0.027323034,-0.056580022,0.020834414,0.043794766,-0.03408043,-0.006496705,0.028110094,0.045376815,-0.019198367,-0.029833412,0.06372691,-0.052021805,0.01877521,0.041429356,-0.0119905835,-0.049955912,0.02107416,0.062846765,-0.05777657,-0.002618345,-0.05678372,-0.0071988576,0.07537745,-0.057374626,-0.061276708,0.035551183,-0.007766752,-0.07857228,-0.042427868,-0.058900416,0.0027125492,-0.06485097,0.1437693,-0.0031364062,0.008460455,-0.027651932,-0.049063377,-0.018811384,0.010108159,0.07842156,-0.038038112,0.026977023,-0.026293905,0.0036018323,-0.066905364,0.12852152,0.046127893,-4.6632415e-08,0.03758072,-0.004179032,0.08516962,-0.009485788,-0.028887523,0.0023255376,0.06314866,0.05733276,0.062126763,-0.049331024,-0.03727337,0.013461555,0.0842295,0.037305005,0.044052538,-0.018145928,-0.065093376,0.02967792,-0.020781383,0.04288399,0.043176457,0.00963556,-0.09055499,-0.035298858,0.055940617,0.008017072,-0.0014440452,0.06601087,-0.035351757,-0.07003496,0.004030152,0.06334368,-0.024751738,-0.025104044,-0.12860341,0.04118591,-0.057684224,-0.05329577,-0.08732255,0.00432268,-0.056052487,-0.09924293,-0.104434215,-0.02005196,0.05538668,-0.004844807,0.04939397,0.014366936,0.01717163,-0.01353763,0.06878535,-0.0505391,0.04614497,-0.04819333,-0.04524803,-0.03752089,0.012018322,-0.012017341,0.034902707,-0.07163932,0.06240349,0.022186518,0.16134648,-0.012906885 +3.1.1.3,"The enzyme is found in diverse organisms including animals, plants, fungi, and bacteria. It hydrolyses triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids. The enzyme is highly soluble in water and acts at the surface of oil droplets. Access to the active site is controlled by the opening of a lid, which, when closed, hides the hydrophobic surface that surrounds the active site. The lid opens when the enzyme contacts an oil-water interface (interfacial activation). The pancreatic enzyme requires a protein cofactor, namely colipase, to counteract the inhibitory effects of bile salts.",384,1.0,-0.017011432,-0.11048605,-0.069589466,0.0014705242,0.046178114,0.056725137,-0.015927266,0.052780807,0.039004944,-0.05837641,0.004380988,-0.039793696,-0.08778797,0.038403895,-0.05793981,-0.036199875,-0.051520813,-0.028922435,0.039125323,-0.12262775,0.113536805,0.04686328,0.023703193,0.013196031,-0.06997678,-0.017349783,0.10147761,-0.09258787,-0.024206169,-0.035039485,-0.009028895,-0.042028222,0.021252327,-0.017060913,-0.021119392,0.07066671,-0.021770503,-0.0077434625,0.02664,-0.015342471,0.09324712,-0.03161346,0.0048716767,-0.046526775,0.050520875,-0.02386426,0.010836861,-0.02160937,0.038068216,0.021066694,-0.08203553,-0.082022354,-0.0017761945,-0.019042455,-0.030235734,0.01086667,0.0016103646,-0.058779225,-0.039345503,0.021769771,0.04222818,0.030079419,0.03219217,0.06451313,0.020206945,-0.113422595,0.03917623,-0.033696894,0.0236074,-0.0453861,-0.095471725,-0.030584082,-0.028887043,0.02046213,-0.01579859,-0.03866776,-0.06526545,-0.02662555,0.0752403,0.004435151,0.068132,0.0059287213,0.041192714,0.14440943,0.026198577,0.017511085,0.0491525,-0.036978256,0.030639522,-0.046602465,0.044964474,-0.031019354,-0.036702476,-0.025576076,-0.03489925,-0.044331193,0.012010819,-0.05061977,-0.0348874,-0.032322206,0.008331384,0.028826753,-0.017195567,-0.099240705,-0.040536556,0.058359236,0.012278275,0.060576346,0.050321132,0.05342397,0.027382337,0.030636666,0.09509719,-0.0050039454,-0.03498701,0.12954688,0.02896386,-0.08812271,0.0050249742,0.025940578,-0.05019448,-0.085660234,0.05431773,0.0503844,-0.054263875,0.076161705,-0.05472342,-8.143914e-34,0.030660005,-0.06159241,-0.019364735,-0.01699093,-0.06325684,-0.0675305,0.009563539,-0.009948065,-0.11138592,0.056559186,-0.029143587,0.022545557,-0.009498001,0.109786265,-0.052890755,-0.03699283,0.043505684,0.024052635,0.03584005,-0.029603051,-0.005726729,0.028152978,-0.021583453,-0.013263997,0.052745834,0.049950078,-0.053245977,0.006046689,0.071759075,0.009697899,0.029773861,-0.02106159,-0.061176226,0.10294881,0.08031017,0.06602428,0.008660741,-0.014346877,-0.045792993,0.02380009,-0.004309195,-0.028744088,0.047600094,-0.056374326,0.07114155,-0.05339508,-0.063044444,0.100264356,0.03507663,0.023013867,0.0608632,-0.006020173,0.0642868,0.027829755,-0.031931575,0.033401318,0.016379973,0.014544886,0.04287094,0.021253835,-0.06138754,0.05775885,-0.11853281,0.027154107,0.009542394,0.08759973,-0.034144826,-0.0491101,0.021212302,0.099002995,-0.08666182,0.01687787,0.0057968567,0.025778905,-0.017211918,-0.046364903,-0.040957797,-0.0016474338,0.014466838,0.029282799,0.08171545,-0.057645123,0.013754205,-0.01497531,-0.095274016,0.018305639,-0.035721887,-0.023370579,-0.029542606,-0.0079652,-0.0027843823,0.020369861,0.0070488374,0.042371422,0.042617373,-1.1001266e-33,0.044211254,-0.09744342,-0.016407995,-0.027804665,-0.027732665,0.024615584,0.04322688,-0.035306644,0.09283879,-0.025719546,0.0025063292,0.00835899,0.08032386,-0.036720876,0.032558575,0.07447108,-0.052605264,0.036234293,-0.042744398,-0.02509348,-0.024447618,0.10345133,0.04110004,0.076610565,0.013555682,0.022859195,-0.040182818,0.05393236,-0.024872899,0.023781734,-0.015844274,-0.012172752,-0.04383516,-0.082696244,-0.098707184,0.010111196,-0.0960725,-0.027568398,0.018189384,0.027457824,-0.023004496,-0.0071549593,0.06810842,0.048363462,0.022847477,0.0429737,-0.061329897,0.018299662,-0.0027389769,-0.059718758,-0.051299598,-0.022544656,0.043052126,0.015380955,0.079934,0.11275217,-0.006763125,-0.041246213,-0.058766138,-0.031905334,0.0051200255,-0.02726591,0.030134408,0.030564774,0.0028726666,-0.013691418,-0.045060918,0.027414285,-0.023555038,0.017471176,0.0057148887,0.017757216,0.06900527,0.023593456,-0.03682738,0.021365672,-0.064402774,-0.013909767,-0.020276517,-0.024464175,0.028060988,0.045092694,-0.005547371,-0.13877559,-0.0075431154,-0.06782343,-0.04082147,0.048856653,0.040787727,0.036620166,-0.059460733,-0.038705863,-0.063031994,-0.07908395,0.028226996,-3.7951025e-08,0.03914008,-0.061188612,0.08706447,-0.027383784,-0.08698388,0.06959648,0.08765019,0.009499398,0.03371521,-0.07357085,-0.08148091,0.105160624,-0.031471647,0.009052465,0.050521303,0.071318105,-0.038977295,0.025968332,-0.04221487,-0.019174583,-0.009343576,-0.060643557,-0.030323831,0.050742604,-0.0002033442,-0.046007425,0.039095294,0.057700522,-0.072961405,0.056200087,-0.07105809,0.03448232,-0.018629331,0.06402187,-0.007139571,0.09219271,-0.025628816,0.004626854,-0.07218337,0.06438843,0.058334596,0.0051472443,-0.08999408,-0.050318725,-0.01001826,0.083838984,0.053925004,0.05769698,0.01192498,0.06271044,-0.037626263,0.004848116,-0.02261552,0.027027398,-0.033069406,-0.014798224,0.009221535,-0.0796618,0.00966646,-0.03892296,-0.023011561,0.03242078,0.2090689,-0.01961584 +3.1.1.4,"Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.",384,0.99999994,-0.036106873,-0.01693695,-0.0034901996,0.028780436,-0.0136793265,0.0084705865,0.0097169345,0.022242436,0.024931408,0.018033154,0.04034467,-0.017409293,-0.038764827,0.030940393,0.0031385748,0.0011108391,-0.017659482,0.013028789,0.01705294,-0.051149644,0.08377366,-0.030465564,-0.003361691,0.01904908,-0.054976534,0.022682983,-0.014812279,-0.0105476985,0.05422413,-0.043755148,0.0138526065,-0.033097044,0.046720397,-0.058089536,-0.09317536,-0.001077775,-0.027915793,0.006091473,-0.056299407,0.017756999,0.09923504,-0.04469652,-0.018686246,-0.021148255,0.056486614,0.013816954,-0.008716655,0.008245662,0.013226562,0.005744037,-0.043476418,-0.04106924,0.015476267,0.1007725,-0.040317748,0.08705012,-0.1023259,0.02950537,0.04407981,-0.012107135,-0.04762462,0.018021746,0.04062039,0.064205356,0.05231051,-0.0625982,-0.03364525,-0.1040311,0.035671473,0.025391279,0.0013296369,-0.08263428,0.02510411,-0.055133708,0.0388587,0.03847094,-0.055709887,-0.06725113,0.031375326,-0.033554554,-0.04140077,-0.017271537,0.007716921,0.11295374,0.034642432,0.047929738,-0.041376498,-0.045054805,-0.08111131,0.055376247,0.051653367,-0.05106833,0.054232955,0.06699314,-0.04077303,-0.05862594,-0.00087725796,-0.016140014,-0.0025147747,-0.014486883,0.0047673597,0.042080346,-0.05276226,-0.029525,-0.039503876,-0.026533093,-0.008621749,-0.060466133,-0.026965609,0.048815455,0.045160443,-0.008849264,0.022707894,0.037218705,-0.0039487095,0.12984551,0.013550459,0.0019035054,0.0036340365,-0.06306065,-0.03259188,-0.11361601,-0.086149916,-0.06840132,-0.07252384,0.0088674575,-0.058295146,3.76974e-33,0.012870001,-0.03180657,-0.0062417826,-0.024812177,0.046869386,-0.022607023,-0.067536235,-0.04310363,0.04865744,-0.027839221,0.04014058,-0.040535573,0.0414228,0.11251882,-0.04489115,-0.07550273,-0.0069562653,0.032302465,0.07617359,-0.04040404,0.0018498237,0.05853422,-0.029254299,-0.01602584,0.017806455,0.089618266,-0.08254728,-0.008999509,-0.0047705187,0.037297577,-0.0031692183,-0.030860258,-0.093314074,0.023410626,-0.019553,0.08888425,-0.009895443,-0.037734937,-0.04610876,0.045239568,0.022308158,-0.0076506175,-0.055740766,0.023830077,0.004696127,-0.080590755,-0.0746682,0.08456612,0.06314393,0.036604077,0.033070643,-0.014273938,0.09297619,-0.009414138,0.008897643,0.008293629,-0.04099053,-0.12696059,-0.035304446,-0.004659463,0.04507642,0.022957686,-0.032354623,0.028315937,0.029002931,0.030408021,-0.047955103,-0.08978387,-0.107791014,-0.012127848,-0.009637475,0.019754687,0.10501967,0.0020792654,-0.032708943,0.0039685555,0.032124385,0.047429573,-0.06036128,0.005719977,0.068848245,-0.050243083,0.071666606,0.04825907,-0.007529848,-0.015326734,-0.00870811,-0.033218425,-0.0010082027,-0.0024691906,-0.012571342,-0.087594725,-0.024743529,0.08980107,-0.045120385,-4.8166553e-33,-0.034818787,-0.028013429,0.07340391,-0.072635025,-0.023506721,0.08178535,0.04135098,-0.04893973,0.08812636,-0.014136277,0.020036237,-0.0021807733,-0.037093654,-0.0027648958,-0.008770157,0.07055355,-0.019273315,0.038676005,-0.058685195,-0.043881927,0.034039464,0.098859414,0.0014416071,0.15565713,0.0902936,0.014238222,0.015310251,0.009022296,-0.04753975,0.05978049,-0.024036955,-0.016089518,-0.09912521,-0.104976706,-0.06459122,0.013161108,-0.084319204,0.0237892,-0.06641593,-0.022674972,-0.0034756095,-0.02306975,0.11982925,0.040059794,0.05203681,0.038592555,0.037946194,0.014943696,-0.06977644,0.009353108,-0.010384036,0.035806373,-0.008485197,0.0846182,0.062700376,0.118171714,-0.037448503,0.026597062,0.009418377,-0.14312612,-0.0037392841,0.012562895,-0.023297183,-0.049984988,0.050848007,0.016876634,0.02761286,0.001278659,0.059247267,-0.038477104,0.066449225,0.04077931,0.062974796,0.030367428,-0.06673628,0.020041598,-0.056873836,-0.08706072,-0.011137017,-0.027518779,-0.037748523,-0.031210586,0.07359711,-0.06146119,0.03768923,0.012291777,-0.047585394,0.032348838,-0.04192117,0.028641561,-0.020345135,-0.021677518,-0.076354355,0.00269275,0.05478436,-3.2620754e-08,0.059694503,-0.10178481,-0.010539906,-0.048698515,-0.11641669,-0.0118286945,0.03864638,0.05367015,-0.010552092,-0.10003673,-0.012566491,0.12356175,0.08736425,0.037549406,0.035034467,0.05148535,0.0027427643,0.0733424,-0.05429719,-0.116190664,-0.0829051,-0.06869944,0.019945199,0.05098336,0.014974744,-0.037813958,0.038751137,0.09654325,-0.022953607,-0.0046387925,0.044324595,-0.0041984622,0.019136364,-0.052557945,0.0657149,0.059816837,0.028515043,-0.022691548,-0.022806268,0.064090036,-0.022544393,0.01991746,0.037354577,0.064448975,-0.009531536,-0.0008586369,0.021862872,0.046185587,0.005201482,-0.027372707,0.010569915,0.0060598943,-0.03447376,-0.03082378,-0.14007612,-0.010820831,-0.007550443,-0.027771112,0.051084768,0.009415667,0.02089487,0.071683705,0.1601939,-0.02170913 +3.1.1.7,Acts on a variety of acetic esters; also catalyses transacetylations.,384,1.0,-0.035671104,-0.077426694,-0.080379315,0.050853446,0.030278804,0.055674527,-0.007695062,-0.015736043,0.03182872,-0.038893454,0.03498729,0.0014096914,-0.10397342,0.0011885025,0.02227778,0.07130454,-0.053320155,0.059461392,0.04974894,-0.019958494,0.07783653,-0.06948146,-0.03707105,-0.021875033,0.05154709,0.0426457,-0.003672393,-0.039759077,-0.006051598,-0.1190041,-0.017085444,-0.01998304,-0.05242012,0.0011911421,-0.005778498,0.035798643,-0.06754495,-0.010820877,0.09764499,-0.036981653,0.06980193,-0.060745638,-0.0014509372,-0.09495678,-0.00036833246,-0.067308836,-0.008541813,-0.0002851263,-0.040611163,-0.048972085,-0.060005,-0.003743424,-0.081639595,0.017345512,-0.023775524,0.029490707,-0.016554546,-0.025133906,0.035249665,0.019694937,0.029893417,-0.0026602508,-0.03376531,0.03788414,-0.06581342,-0.06489412,0.035468075,0.0076502603,-0.0045347353,-0.013204163,-0.046106134,-0.077408776,-0.087213054,0.054483455,0.0599837,-0.078848444,-0.040530745,0.008160919,0.05604847,0.0053542308,0.033515614,-0.02169678,0.010110564,0.0479289,0.057318483,0.061934948,-0.0022349306,-0.06398616,0.0421174,0.060723018,-0.030411016,-0.0563861,-0.006650218,-0.037271447,-0.018380562,-0.003986047,0.07532992,0.028414914,0.07415331,0.009354772,0.05284652,0.09857544,-0.044533424,-0.09123707,-0.08168465,0.03290289,0.01590831,0.0767512,0.017224925,0.0324256,-0.046154976,-0.024384439,0.06435154,-0.0788332,-0.0895089,0.097785935,-0.040909052,-0.076007344,0.014807551,0.011499313,0.02128231,0.003337599,0.03366441,0.10393514,-0.031603776,0.042887926,-0.015730707,-3.22925e-34,0.024158895,0.06384733,0.00059253705,0.07107985,-0.011859771,-0.052814193,-0.117310345,0.0076521225,0.0048175077,-0.038715445,-0.04802423,-0.027403872,0.00067930255,0.06481572,0.049800534,-0.03489193,0.009001901,0.044095114,0.049007475,-0.06541944,-0.024293032,0.048478514,-0.07505871,0.06441707,-0.017563682,0.02245654,-0.04800632,0.02082455,0.023459606,-0.018912204,0.014428286,0.027239418,-0.046663795,0.0071260277,0.019846128,0.050680865,-0.022894036,-0.06583584,0.06304452,0.009696403,0.06932319,0.019047966,-0.041243058,-0.004311223,0.02363924,0.009483442,-0.017499434,0.096120566,0.065498605,-0.016075058,0.0018655063,-0.04962973,0.083674565,0.04313924,0.010995972,0.08575711,-0.03922869,-0.053518496,0.03765602,0.02351637,-0.038333274,0.0055774963,0.027534882,-0.017805465,-0.059658293,0.017534303,-0.017334802,-0.02890232,-0.004882941,0.05759806,-0.068207726,-0.0021504366,0.10268588,0.04188198,0.05549153,-0.018889716,-0.071663834,-0.023831964,0.066491336,0.03105275,-0.021778438,0.0040801354,-0.011305761,0.011758225,-0.007938953,-0.039805014,-0.06802864,-0.11149287,0.021486398,0.10403558,4.85908e-05,0.0071287015,-0.09598045,0.056621704,0.011805459,-2.7364785e-33,0.046822958,-0.08068956,-0.025119726,-0.051608726,-0.10717563,0.034541942,0.009464075,-0.040728994,0.02419838,0.014740705,-0.006817224,-0.0098448405,0.02760566,-0.10659434,-0.035718493,-0.072655074,0.036472645,0.060765915,0.0010758087,-0.0026407014,0.01206296,0.06954483,-0.0019432423,0.05421954,0.06593503,0.03582129,-0.054271087,0.04925006,0.0655026,0.044566125,0.029199444,-0.07455309,0.016705122,0.020317608,-0.06396774,0.14643362,0.038568273,0.09515502,-0.03352083,-0.0030426504,0.011160663,-0.030201457,0.0338573,0.086483285,0.08968101,0.007258231,-0.036026526,-0.014977183,-0.050983433,-0.09323582,0.06971535,-0.0077413176,-0.07378819,-0.03275961,0.030298647,0.06581837,-0.0023362604,-0.07341035,-0.014427311,-0.05147829,-0.052425545,-0.00052719103,0.019454774,-0.08987524,-0.008951018,0.027616633,-0.036060736,-0.0018091975,0.022177435,-0.05741787,0.10281127,-0.007496388,-0.026946565,0.031321496,0.059182703,-0.090345204,0.014612171,-0.103363365,-0.07300952,-0.08480039,-0.052423235,-0.028516823,-0.004819417,-0.07905183,-0.120863415,-0.014141003,0.0024374588,0.004525832,-0.050051175,0.042671517,-0.03464354,0.05312244,-0.012254575,0.02779436,-0.0269779,-2.3661029e-08,-0.019021735,0.023917155,0.10139822,-0.042081058,-0.05196291,0.03797696,0.046620514,-0.013852354,0.035764832,-0.077455714,-0.0822409,0.08827688,0.07331762,0.0341111,0.08927971,0.011506894,-0.047937475,0.00990284,-0.07171917,-0.028368382,-0.06153025,0.04430884,-0.051077705,0.0074717603,0.003503677,-0.078853056,0.05040155,0.05786289,-0.017875357,0.04009923,0.006004546,0.034250066,0.011016813,0.008666923,0.023816988,0.031185126,0.056380354,-0.081378095,-0.02303468,0.019494241,0.0027660888,-0.008061498,-0.12609628,0.040165458,-0.022385877,0.03706504,-0.051246483,0.018749956,0.029260091,0.038918693,0.10563981,-0.02315234,-0.03249763,-0.049471855,-0.059744593,-0.031695873,-0.013288088,-0.015884744,0.06818077,-0.033977494,0.07217343,0.010071153,0.18413804,-0.0037312335 +3.1.1.8,Acts on a variety of choline esters and a few other compounds.,384,1.0,-0.044473413,-0.18191965,0.018016383,0.04339852,-0.008803514,0.046691816,0.015628064,0.017573932,0.028008856,-0.039081857,0.073076464,0.0034041232,-0.12477407,-0.023452533,-0.0041374704,0.12522998,-0.05102468,-0.0070625297,0.011145349,-1.6780048e-05,0.035127725,-0.06654623,-0.037973866,0.04417289,-0.024174765,0.01417402,0.06440147,0.03243006,-0.010081714,-0.12585054,-0.009283366,-0.028827114,0.10358605,-0.04353726,-0.036477584,-0.0032418338,-0.006452298,0.01617287,0.06258254,0.009689776,0.06905774,-0.06983925,-0.02449892,-0.042560667,0.055226736,-0.09849087,-0.0022023155,-0.0046852203,0.025431639,0.0056933393,-0.058305636,-0.010343443,-0.05893888,0.014799093,-0.04447995,0.04551241,-0.11188296,-0.035611883,0.07930841,-0.015758188,-0.03646892,0.020330021,0.01594619,-0.0025309988,-0.045621924,-0.0027300273,0.034039427,-0.008088262,0.080423996,-0.021066777,-0.033557884,-0.10514103,-0.0757853,0.014157874,-0.020609576,0.0053954045,-0.037669964,-0.058515467,0.065946385,-0.04190048,-0.058967628,-0.029617412,-0.007904409,0.085409865,0.068105906,0.054695982,0.0004968055,-0.072139,0.006864411,0.055957545,0.016692167,-0.036607236,-0.012191611,0.02393935,-0.041662414,-0.034753915,0.07682395,0.0076979706,0.031983595,0.015967824,0.04518969,0.014858555,-0.038697604,-0.11116307,-0.09976873,-0.00414974,0.05348969,-0.0043483735,-0.0034318636,0.024522116,-0.06988993,-0.01884733,0.03589732,-0.06792131,-0.08007717,0.072378725,-0.013938374,-0.016559474,0.017954899,0.07734151,0.039685592,0.0046093706,0.0367243,0.09394201,-0.06112756,0.011453924,-0.00056534295,-2.4108434e-33,0.0082988525,0.017883599,-0.008359027,0.05473216,0.013594271,-0.055686556,-0.14394769,-0.027289048,-0.008841107,-0.034018707,-0.0322171,-0.019869488,-0.018634645,0.03155211,0.026154464,-0.0046913354,0.023855802,0.023080483,0.076139,-0.022033762,-0.09038607,0.09841115,-0.071491204,0.030901652,0.0112212645,-0.040596742,-0.027962621,0.015070008,-0.03227385,0.016846908,0.1004529,-0.060322985,-0.013847716,0.031526875,-0.047963224,0.1180609,-0.08810411,-0.06058462,-0.014479686,0.058272347,0.06075054,-0.0112101985,-0.022702258,0.021375716,0.01330824,-0.01925688,-0.0065300856,0.13394031,0.034637418,0.0032507484,0.021418348,-0.04793774,0.071841806,0.060224935,0.045973774,0.06117255,-0.05855379,-0.03486002,0.043719463,0.05881323,0.031008154,0.05135387,-0.07698171,-0.017905843,-0.020607945,0.025034934,-0.070654705,-0.052354034,-0.038935047,0.019345053,-0.07237576,-0.014423082,0.09007991,0.038328413,0.03341325,0.013728625,-0.04475028,-0.0075933225,0.049101617,0.004704101,-0.02777324,-0.020717056,0.024118612,0.022833707,-0.07743846,0.006124255,-0.055192985,-0.038356427,0.038420286,0.06659028,-0.0028526247,-0.07622999,-0.10189537,0.048825677,-0.0064973664,-3.7679257e-34,0.0039711087,-0.063992985,0.03837837,0.036536373,-0.080701895,0.09396854,0.0022490243,-0.04166697,0.05495168,0.0114429975,0.010598729,-0.037650354,0.02248799,-0.103978805,0.007854963,0.091379076,0.054442547,0.09405077,-0.013180385,-0.043054517,-0.08069824,0.06866277,0.05241264,0.0901451,0.012906692,0.059122246,0.0244551,0.018596629,0.020254249,0.07004366,0.020998564,-0.04398163,-0.03144049,-0.055487204,-0.059196483,0.06629385,0.0014358101,0.057492655,-0.002307038,-0.0043380302,-0.04580017,-0.016750276,0.1418075,0.03565289,0.044350777,0.04138539,0.027623877,0.016134236,-0.052783176,-0.011875663,0.021882761,-0.009867507,-0.024719695,0.005611576,0.04071142,0.11631592,-0.001118475,-0.049901843,-0.0056255544,-0.086143106,-0.05212193,0.026247345,0.023982186,-0.035783622,0.012402838,-0.0030052578,-0.04169385,-0.06762296,0.053654775,-0.082937986,0.08567086,0.012727421,-0.036635272,0.015534141,-0.009389988,-0.012305474,0.0011132874,-0.09178536,-0.048703358,-0.063518286,-0.0035463348,-0.034151353,0.049334653,-0.06270444,-0.07450008,0.04534565,-0.026189018,0.06335608,0.066852696,0.03446228,0.015786171,0.03388694,-0.086308375,0.054086965,0.0361879,-2.1359346e-08,0.014716674,-0.051019974,0.065485716,-0.04474448,-0.01738901,0.023199093,0.020733353,-0.016381593,0.023812702,-0.034142353,-0.021090016,0.13871008,-0.0028236352,0.004676,0.04810265,0.04049183,-0.02706577,0.052664645,-0.07977315,-0.03586226,-0.06325628,0.002032211,-0.0049572163,0.015559501,0.012079989,-0.10059162,0.03374139,0.090105064,-0.008144313,0.022406535,0.08692993,0.030443074,-0.017097985,-0.05269992,-0.024729699,0.02568077,0.008520932,-0.10658363,-0.030156398,0.10506735,0.024672857,-0.044054683,-0.020803144,0.01385966,0.03412532,-0.0026691882,-0.07740446,0.012003024,0.013078169,0.0440094,0.008127546,-0.01753428,-0.0026787822,0.0028579163,-0.08427384,-0.013126969,0.0064447946,-0.04142769,0.07220719,-0.051871575,4.2880438e-05,0.00790723,0.12858039,-0.013200338 +3.1.1.10,Also acts on cocaine and other tropine esters.,384,1.0,0.00022789543,-0.09234476,-0.03892492,0.064772345,-0.011542323,-0.007623954,0.06811282,0.033781294,0.0027544918,-0.05611805,0.040351167,0.039250005,-0.093000196,0.03150665,-0.00038033404,0.01814289,0.015354225,-0.038695123,0.026605666,-0.047640763,0.051559776,0.01710029,0.060592547,0.032263793,-0.10036459,0.024708869,-0.016098462,-0.013251838,0.0017970711,-0.03581652,-0.043033633,0.07005268,0.00074571505,-0.025613757,-0.057653204,0.04257151,-0.04824627,0.06797104,0.10767387,0.052782,0.07284229,-0.10414784,0.001346903,-0.032901272,-0.05443366,-0.080623195,-0.0031863917,0.052322935,0.035329696,-0.0074159,-0.0034916345,-0.05398217,0.03440245,0.0126463175,-0.015064938,-0.006687474,-0.08524367,0.012892015,0.003834747,0.029173445,-0.039797783,0.085961014,-0.0036704598,0.0224348,0.015778052,0.018246308,0.00285447,-0.011522495,0.018581567,0.0038052062,-0.00989696,-0.096703455,0.013270333,0.0576221,-0.02337532,0.03658325,-0.02156743,-0.05194186,-0.058271114,-0.015084908,0.0022140867,0.001550356,0.0032952533,0.021320414,0.06609538,-0.04402518,-0.060837626,-0.027934778,-0.08501541,0.07565802,0.053641155,-0.04893142,-0.054455314,0.003010646,-0.0359145,-0.043993965,-0.001398351,-0.026955783,-0.052228272,0.0032570953,-0.015133424,0.035159368,-0.0038199336,-0.046264883,-0.03797409,-0.013320656,0.050575186,-0.027549617,0.02945467,0.0137439035,-0.0889883,0.05616112,0.030858204,0.04915831,0.0037181617,0.075768195,0.023579827,0.004907846,-0.039621342,-0.019037735,-0.013655135,-0.01871325,0.017628202,0.039827053,0.019882172,-0.0150130475,-0.07994398,-1.1055298e-33,-0.010522415,0.012559965,0.03706553,0.041082337,0.052867796,0.062218133,-0.06862871,-0.014332615,0.07995503,0.030010838,-0.07048259,-0.0634972,-0.008468505,0.083905414,0.014957003,-0.009013585,-0.061556913,0.05037741,0.055809226,-0.036997855,-0.04543189,0.054485492,-0.07364504,0.035524707,-0.08431956,0.06606831,-0.06848091,0.03557128,0.020074137,-0.0064984253,0.036231246,0.0338923,0.011605634,0.0006909696,-0.023941271,0.06859304,-0.019009724,-0.014211661,-0.0969013,0.10639917,0.031938173,0.04270174,-0.01387514,-0.0017015092,-0.021562487,-0.022166323,-0.07382165,0.038826246,0.097478054,0.013180513,0.054357547,-0.04906631,0.035335194,-0.034178793,-0.013617038,0.075184606,-0.05167475,-0.080635056,0.0138153555,0.06978638,0.04834413,0.06731901,-0.045304865,-0.038904905,-0.10547749,0.014285863,-0.030048309,-0.10944329,-0.11490051,0.08592322,-0.06179386,0.03265692,0.09431722,-0.014320385,0.045212224,-0.042225976,-0.041417904,-0.020708386,0.04935391,0.026721016,0.034599412,-0.13971302,0.14270903,-0.011945814,0.010473702,0.022980753,0.0023052704,-0.062267184,0.0759776,0.0640413,-0.03886494,-0.07070367,-0.09445352,-0.011237198,-0.017721144,-1.46255815e-33,-0.029186102,-0.07417899,0.05382313,0.0037869134,0.011486992,0.04498714,-0.0020882492,-0.019176032,0.028651327,-0.050779972,0.06271804,-0.039977893,0.03391142,-0.027374145,0.07117138,0.022803105,-0.005721502,0.066559464,-0.0730715,-0.031314727,-0.0744888,0.020177832,0.011997927,0.049136672,0.0026044517,0.022820588,-0.03610047,0.053543054,-0.002259148,0.05636247,-0.020523783,0.052087884,-0.1046688,-0.05838752,-0.07261683,0.07943322,-0.08614167,0.015185549,-0.043322396,-0.06345487,0.024867965,-0.02073778,0.074302904,0.06340749,0.012951954,0.012452951,0.019202298,-0.06287298,-0.08942786,0.017803522,0.032898482,0.050344385,-0.016771564,0.031014849,0.050535347,0.040602386,-0.0424078,-0.14930259,-0.0305226,-0.03015179,-0.042102758,0.07289848,-0.08127624,-0.039022904,0.08465428,-0.071714334,-0.042833984,0.04131098,0.09708977,0.01424833,0.15682037,-0.081635505,-0.047502317,0.043568786,-0.0861899,-0.028792663,-0.10063942,-0.03397494,0.024849676,-0.03841293,-0.048518337,-0.06352743,0.0060188402,-0.0321384,-0.077423595,0.03808817,-0.020725725,0.062017992,0.02717253,0.07407362,-0.030355508,-0.03816062,-0.06354645,-0.0032983613,0.015471693,-1.8989004e-08,-0.0058458056,-0.059046477,0.047462907,0.06275974,-0.03524024,0.060500313,0.08331751,0.03564881,0.037114665,-0.026903376,-0.017248522,0.11690241,0.053147826,0.021719947,0.040635753,-0.019936591,-0.027675072,0.013579647,-0.017805535,0.0322966,-0.108726904,-0.0023619402,0.027805071,-0.014837176,0.026190111,-0.07419837,0.015413337,0.10950932,0.036920387,0.049550552,0.012952903,-0.05077459,-0.018211173,-0.004804591,0.013365668,0.035830688,0.052869584,-0.050408643,-0.0395409,0.02569818,-0.018757354,-0.05472062,-0.055849575,0.060662825,0.018877003,-0.044288516,-0.021772034,0.060161542,0.05751925,-0.019868115,0.058747236,0.02740893,0.024935052,-0.021217346,-0.0031408644,-0.011354833,-0.035044514,-0.021519734,0.019572984,-0.04026507,0.0073813056,-0.012447721,0.17815223,-0.015277334 +3.1.1.13,"A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts.",384,1.0,0.00052329665,-0.08690185,-0.018904582,-0.021259364,-0.023291528,0.03127549,-0.019721316,0.0029414066,0.031391762,-0.061757065,0.03868918,-0.00492302,-0.07786687,-0.032629665,0.018616159,0.007202823,-0.05558254,0.0650288,-0.04288899,-0.07168662,0.0724093,0.0032231107,-0.04011815,0.027801821,-0.03190865,-0.0012886164,0.05557611,-0.0022003364,-0.014317398,-0.04449916,-0.0018548084,-0.037261613,0.10198971,-0.055789586,-0.04531306,0.12866832,-0.037806783,-0.047837082,0.0013617033,0.050096694,0.082103185,-0.042723447,-0.038038656,-0.07925353,0.013277523,-0.08516031,0.033680715,-0.011905945,-0.0683804,-0.013464439,-0.02356237,-0.07885829,-0.018696362,-0.013026449,-0.003972889,-0.021962916,-0.035342045,-0.07019417,-0.044933695,-0.02706064,0.031743366,-0.008435296,0.023333315,-0.0064779,-0.06933824,-0.033454597,0.04392725,-0.021351762,0.048110217,-0.02012194,-0.06811019,-0.057834245,-0.10378222,0.07901556,-0.015417973,-0.045885377,-0.05006153,-0.045210183,0.031882666,-0.06816098,0.053057715,-0.03884182,-0.048356466,0.04765999,0.0823363,-0.0073893946,-0.025682213,-0.01882661,0.011605408,0.07596437,0.034028865,-0.10184029,0.003539712,-0.0013522947,-0.0014337585,-0.029620806,0.03809321,-0.029378545,0.037410714,-0.03630124,0.015781354,0.061311256,-0.025813939,-0.056125466,-0.04630748,-0.005916667,-0.016634293,0.043523207,-0.004796885,-0.009809559,-0.04209683,-0.037719507,0.09750667,-0.0623975,-0.062124416,0.109635964,0.012203627,-0.06375103,0.011515811,0.010657201,-0.0018303015,0.04815221,0.048045646,0.0577722,0.0692036,0.07988736,-0.07174871,-1.6765718e-33,0.013379971,-0.0074134315,-0.0037345798,0.105850294,-0.027317831,-0.03720319,-0.044784036,0.0045861453,0.010256185,-0.06680325,0.05075468,0.028528895,-0.009461682,0.074331984,0.060143113,0.01690088,0.081634335,0.09661749,0.14441723,-0.061877485,-0.059433468,0.11578588,-0.047106788,-0.04817993,0.01504341,-0.02503812,-0.050478473,0.008620102,0.028277716,0.015482694,0.03689833,-0.031249536,-0.058940303,0.042505007,0.08392893,0.08711411,-0.02717391,-0.06267396,-0.00090110244,0.07808476,-0.003892894,-0.045090962,-0.037969857,0.012029076,0.024164401,0.032421317,-0.11331511,0.09096471,0.090212606,0.04710394,0.03142392,-0.0062678983,0.038061734,-0.012773856,-0.020648306,0.05884525,-0.061807726,0.017761566,-0.029619316,0.049405623,-0.037866596,0.1345747,-0.09418892,0.068318374,-0.03719403,-0.028546667,-0.031822965,-0.050362073,-0.022213306,0.084538594,-0.07148415,-0.014418808,0.01616735,0.049398735,0.026148127,-0.009913517,-0.06740276,0.011472513,-0.0101375235,0.0049623265,-0.070397384,-0.053882226,-0.019532546,-0.054170936,-0.08008288,0.020443587,-0.012392185,-0.035139002,-0.010689725,0.021415459,-0.07989925,0.026137283,-0.10319526,0.10109793,0.036929768,-2.5038797e-33,0.047246404,-0.09089184,0.007268643,-0.012870784,-0.034265935,0.04120576,0.00084281364,-0.03769842,0.0028121087,-0.03617075,-0.003920433,-0.04021882,0.017135276,-0.07273935,-0.038355455,0.0011736329,0.0005024548,0.06446194,0.014617459,-0.0038251095,-0.03149255,0.049119093,0.044616405,0.13044836,0.02229279,0.011840238,0.0050353035,0.058909547,0.03551173,0.08153182,0.008798943,-0.055454936,0.022617167,-0.047638558,-0.07355776,0.048703313,0.053510886,0.012705236,0.032257307,-0.020050908,-0.009042883,-0.03890465,0.051433872,-0.051285148,0.038480647,-0.015305714,0.010636115,0.003649483,-0.013356411,-0.073051475,0.044214517,0.019165663,0.03258574,0.059291583,0.028990488,0.033197314,-0.05263502,-0.03091348,0.034770504,-0.06544203,-0.05896717,-0.0052382834,0.036407784,-0.0068630734,-0.00058858877,-0.0211646,-0.0033996857,-0.15784346,0.04594216,-0.024505418,0.055399958,-0.059649836,-0.012954766,0.07288069,-0.018645134,0.00830359,-0.054479577,-0.06427774,-0.032767177,-0.054815654,-0.030009743,-0.04766843,0.08524654,-0.03807076,-0.05403648,-0.0073822904,-0.03947771,0.08026349,0.016694603,0.009618925,-0.016507596,-0.03454144,-0.10301632,0.0093009295,-0.039145995,-2.9640391e-08,0.037830535,-0.041835856,0.057080764,-0.044538204,-0.03960673,0.0081227785,0.026580818,-0.0145998,0.047633074,0.013185726,-0.047915895,0.16404855,0.020405667,0.009977282,0.077242084,0.024583101,-0.051208343,0.023706071,-0.029073026,-0.046161994,-0.024726715,-0.011607194,-0.025328983,-0.023088701,0.03925256,-0.08553214,0.019253915,0.052896496,0.012560249,0.040821724,0.039100856,0.011972325,0.025888825,0.0038748037,0.06653539,0.07754007,0.012072247,-0.089149624,-0.051588465,0.12748946,-0.023782063,-0.03963881,-0.04599423,-0.0024083313,0.018466681,-0.007431755,0.0171501,0.08422335,0.002180473,0.044207387,0.017700316,0.017770372,-0.03834875,-0.0072962446,-0.09356709,0.007765306,0.01843264,-0.08396436,-0.012497404,-0.011251711,0.08092698,0.039215725,0.21026364,0.016193166 +3.1.1.14,"Chlorophyllase has been found in higher plants, diatoms, and in the green algae Chlorella [3]. This enzyme forms part of the chlorophyll degradation pathway and is thought to take part in de-greening processes such as fruit ripening, leaf senescence and flowering, as well as in the turnover and homeostasis of chlorophyll [4]. This enzyme acts preferentially on chlorophyll a but will also accept chlorophyll b and pheophytins as substrates [5]. Ethylene and methyl jasmonate, which are known to accelerate senescence in many species, can enhance the activity of the hormone-inducible form of this enzyme [5].",384,1.0,-0.04328047,0.01301166,-0.06027053,-0.030823953,0.11274201,0.080079265,0.004246657,-0.020876486,-3.5207908e-05,-0.0115042515,-0.004642541,-0.045611173,-0.03593653,0.024172679,0.018957585,0.14101551,-0.17277034,0.009214043,-0.07767795,-0.08056879,0.028012522,-0.010655048,-0.072843894,-0.014900881,0.044386916,-0.047319163,-0.03156988,-0.05653536,-0.024373773,-0.07698374,-0.040766615,0.06120609,0.04590794,0.0075374073,0.0300492,0.04456072,-0.014496403,-0.14538415,-0.033213113,-0.016276035,-0.0017309252,0.048860226,-0.09166777,0.024009202,-0.06070466,-0.026929768,-0.007787801,-0.048128355,-0.013661007,-0.0062467223,-0.038945887,-0.048336394,0.016689586,0.009909721,0.0029562598,-0.033286013,0.030042611,-0.0023797536,-0.02538104,-0.00077372644,0.029431831,-0.058239218,-0.0067974026,-0.037734132,-0.012530599,-0.051353496,0.023823766,-0.070062004,0.032627966,-0.06043076,-0.085475266,-0.06621988,-0.03742199,0.03745799,0.028252652,-0.033047386,0.0084719015,-0.02818887,-0.051097047,-0.009807794,-0.010348357,0.04608113,0.0142480945,0.04405838,0.03390729,-0.020387901,-0.049219586,-0.0105265295,-0.020864537,0.03644256,0.011833933,0.046443988,-0.063040234,-0.0009801931,-0.08243588,0.11306821,-0.0402979,-0.13014166,-0.022405181,-0.040110376,-0.0030558114,0.034825712,-0.08596942,-0.07340931,-0.079978615,0.06483081,-0.0237825,0.03134785,-0.017860983,-0.02460771,-0.0042169946,0.017240953,-0.0016807141,0.06488863,0.008050662,0.06351029,0.01567455,-0.0023480456,0.0223412,-0.03714146,0.010513707,-0.030030593,0.0035585104,0.03312054,-0.03498816,0.11246964,-0.06557931,4.012302e-33,0.056930173,0.019896373,-0.058312982,0.006683363,-0.00786267,-0.05282466,-0.05847732,0.053653006,-0.054287683,-0.16448161,-0.010779548,-0.036887534,-0.03136845,-0.09113765,-0.0046577947,-0.040115256,0.013826021,0.036653567,0.018744022,0.03193945,0.03396185,0.034050994,-0.065956965,-0.009742278,0.037320748,0.056079987,0.041498587,0.065968946,0.042693485,-0.03794128,0.062671006,-0.013365141,-0.06787918,0.02859092,0.06294507,0.03682949,-0.026351204,0.072650574,-0.0054425993,0.12583297,-0.01957343,0.029146543,0.012330033,-0.011661334,0.05077335,-0.049338203,-0.031239504,0.039548643,0.022647323,0.09444041,-0.0466705,0.012295305,0.07513234,0.021210179,-0.03299204,0.075177655,0.020359984,-0.052846186,-0.038819242,-0.012489053,-0.0105099995,-0.0139055075,-0.041076038,0.017492848,0.04332928,0.04524913,-0.05851336,-0.025347976,-0.020288732,0.075028524,-0.030731354,-0.07200435,0.043691702,0.029941518,0.07811775,-0.11017164,0.002562866,0.04005273,-0.02374181,0.013887465,0.062398,-0.012695911,0.05052882,-0.052003987,-0.0383244,-0.0533805,-0.011459531,-0.04878623,0.051358216,-0.009493143,0.03933425,-0.058917213,0.05388468,0.009412267,-0.040045556,-4.2239097e-33,0.05925242,-0.1193575,0.035835944,0.012652753,-0.023822954,0.031674907,-0.03382827,-0.02400704,-0.069984466,-0.026166325,0.068383455,0.079789564,-0.030045008,0.012116178,0.023206297,-0.020666933,0.05740318,0.11878656,-0.048979256,0.0067354264,-0.043387678,0.09870592,-0.005346011,0.006700416,0.093685485,-0.007162313,0.0055901436,0.047174808,0.0505476,-0.038786743,-0.05069025,-0.006917868,-0.03069538,-0.00882264,0.054679148,-0.021736298,-0.07012232,-0.005791489,-0.01976286,0.12537062,-0.022298384,0.020994565,0.030570202,-0.031141834,0.026397945,0.001857135,-0.11242829,0.065695755,0.0061329133,0.005586214,0.055815566,0.042855248,-0.022795098,0.00062271574,0.043371513,0.027757084,0.0804596,0.052149296,0.03786079,0.0011553109,-0.02757211,-0.052625455,0.061171483,0.0498365,0.028687453,0.05836075,0.022712989,0.13289069,-0.008723454,0.082763925,0.062092677,0.06309426,0.03856663,0.05906567,-0.07433747,-0.053838473,-0.061826304,-0.023501717,-0.061387654,-0.0034491427,-0.009608089,0.005419332,-0.023197556,-0.047850862,-0.050304536,-0.07677324,-0.028641487,0.047168754,0.005194737,0.018330397,-0.012322193,-0.07524212,-0.045315344,0.067882776,0.04670952,-4.2883407e-08,-0.0010719678,-0.034597605,-0.038176242,-0.05407493,-0.010139288,-0.019852433,0.013065297,-0.010130064,0.07033763,-0.026133679,-0.030205296,0.10125185,0.07924467,0.051650748,-0.007990021,0.0026832037,0.05036341,0.006624739,0.037438754,0.106343694,-0.064580284,-0.0027374136,-0.1431254,0.05683768,0.037600372,0.00020916444,0.04359421,0.1666898,0.08064909,-0.03716501,0.009386237,0.06032318,0.08298422,0.01498649,-0.042350825,-0.0003901858,0.017252991,-0.019813353,-0.10836848,0.08166306,0.013448861,-0.016864063,-0.04560193,-0.0047002104,0.010805406,-0.046719253,0.074217334,0.0075892443,0.019173965,0.044348277,0.03525595,-0.029436667,-0.01514323,-0.039797705,-0.084294826,-0.0042716106,0.011119091,-0.023098674,-0.035415526,0.00055782683,0.014500336,-0.0040690782,0.1289043,-0.0027735683 +3.1.1.17,"Acts on a wide range of hexose-1,5-lactones. The hydrolysis of L-gulono-1,5-lactone was previously listed separately.",384,0.99999994,0.009150113,-0.11008336,0.035429645,-0.005081167,0.07017127,0.06754217,-0.010666238,0.029538564,-0.053499468,-0.025618974,0.011572268,-0.006581122,-0.08503378,0.019791111,-0.040185135,0.04427413,-0.043612875,0.012544459,-0.037209332,0.019355636,0.16741323,-0.0102456305,0.009176489,0.035669994,0.11000637,-0.01703729,-0.013101176,0.018918289,-0.005177582,-0.15413183,0.009705831,-0.018671872,-0.0014876844,-0.01894341,0.028680766,0.053945147,-0.013193193,-0.039318535,0.049203847,0.0012011117,0.0504295,-0.059033707,0.028156985,-0.026314024,-0.083982274,-0.080641806,-0.056404356,0.02646597,-0.05634743,0.029799983,-0.03643,-0.0877883,-0.043256946,0.009171852,-0.03239348,0.00352438,-0.10451423,-0.021283818,0.032057166,-0.0024852315,0.019872049,0.07294376,0.011410407,0.033115886,-0.057123154,0.010863985,0.070041284,-0.06583201,0.0054070107,0.044707205,-0.029906888,-0.11750464,0.038032252,-0.03509653,-0.02489567,0.04170853,0.010876486,-0.047768466,0.024359457,-0.012639063,-0.016019778,-0.02013583,0.047742322,0.050061584,0.013225222,-0.0073515372,0.037121158,0.0809342,0.061802067,0.030934079,0.013454624,0.0071479995,-0.03334607,-0.00898181,0.0018649506,0.041974932,0.017887283,0.01882693,0.039453965,-0.046649057,0.01651071,0.0005651896,3.463059e-05,-0.020500364,-0.009851749,0.06757364,0.010418272,0.023540823,0.015722675,-0.058432315,-0.081662506,-0.008466701,-0.009488173,0.007720338,-0.05758039,0.04434305,0.039240688,-0.044601582,-0.024193607,-0.04169941,0.02602411,0.017632399,0.032386553,0.0663065,-0.07075809,0.06889527,-0.060890645,-7.421701e-34,0.026811646,-0.017138073,0.014168754,-0.06853016,0.008220712,-0.011883777,-0.13237597,-0.006833563,-0.07399093,0.022154776,-0.0585399,0.04475835,-0.02008441,0.0713821,-0.032723002,0.0062111486,0.06634811,-0.032233495,0.016367223,-0.07068831,-0.085691385,0.08657888,-0.13052288,0.04639558,-0.015000502,0.059181686,0.02474086,0.009636721,0.014361889,-0.007938198,0.010441694,-0.04098093,-0.017712953,0.095253825,0.022872245,0.11943414,-0.0535577,0.020805515,0.02731015,0.017124044,0.049838897,0.06801608,-0.041956536,-0.004901546,-0.011083418,-0.07967208,-0.07636653,0.05088708,0.06568198,-0.037364133,0.034445614,0.019216195,-0.00016967737,0.057050586,0.0039823214,0.02129648,-0.020762453,0.10045794,0.08034792,-0.009563732,0.020317942,0.018067142,0.019985229,-0.031828478,0.05627533,0.02881308,-0.051356208,-0.0074866638,-0.032461826,-0.028305499,-0.117508516,0.004158132,0.088865295,-0.017265992,0.03758223,0.031971537,-0.000715548,-0.04619416,-0.03975232,0.10410794,-0.0016431537,-0.04284329,-0.01053964,-0.032715593,-0.1005654,0.029179025,-0.007501704,-0.050986517,0.008042337,0.056129187,0.017549187,-0.054873105,-0.004742161,0.0011849818,-0.00037564404,-1.1266461e-33,0.066528365,-0.03158507,0.087967336,0.02334601,-0.06766684,0.017967662,0.024302026,-0.05247617,0.028967865,-0.0042865584,0.038845606,-0.02108874,-0.02172711,-0.080843,-0.014121358,0.060143106,0.04443415,0.065925896,0.028600072,-0.027254714,-0.06488313,0.1571129,-0.010985063,0.05522796,0.067793526,0.03980438,0.038074743,-0.041985855,0.024052264,-0.010974009,-0.0078535825,-0.04087406,0.047189206,-0.09985614,-0.057755135,0.024234587,-0.050865438,0.057713293,0.015751313,0.030369626,-0.011031679,-0.06844587,0.06479511,0.050501905,0.056581184,0.11374662,-0.015653877,-0.006993209,-0.042225637,0.040178265,0.023466086,0.050753728,-0.064572304,0.01402127,0.07645949,0.043625887,0.028477658,-0.07577577,-0.059197392,-0.040265515,-0.017118284,0.051338848,-0.015211461,-0.068415515,0.07000886,0.09506188,-0.11335933,0.017834987,-0.024070239,-0.013005883,0.038375013,0.049547374,0.028171659,0.0198838,0.020058222,-0.03227834,-0.107714005,-0.117569245,-0.057812378,-0.11061387,0.06470805,0.049566556,-0.030139465,-0.05849447,-0.009217174,-0.07122724,-0.01683558,0.12269026,0.1037645,0.016259214,-0.026363835,-0.050293393,-0.099608466,0.02481534,0.075518355,-3.0785856e-08,0.03818633,0.0053351354,0.023460303,-0.02295227,0.008034801,0.059245255,0.013964339,0.042923473,0.12055181,-0.015246339,-0.029151527,0.06232433,0.040837295,-0.038282577,-0.0064764614,-0.07645617,-0.025962915,0.0029898912,-0.015684877,-0.0025748136,-0.07641318,-0.050396957,-0.017291639,-0.008497208,-0.024094928,-0.08821603,0.012229024,0.048444424,-0.051534817,-0.05068025,0.006788507,0.08422057,0.0053875637,-0.035265185,0.0070571033,0.095759265,-0.05321491,-0.030793443,-0.0042011193,0.025431694,-0.007911599,-0.085090645,0.00645901,0.013145608,-0.064199425,-0.015749075,-0.012317407,-0.037675582,0.047508273,0.043002658,-0.00110136,0.0010217491,-0.024349999,-0.011274325,-0.030506257,0.0032936595,0.028870635,0.0074269385,-0.004472315,-0.11549909,0.015235926,-0.06818652,0.14620537,-0.079777405 +3.1.1.20,Also hydrolyses ester links in other tannins.,384,0.99999994,0.022229528,-0.11970849,-0.03165785,0.045556743,0.08811859,0.009537059,0.030480277,-0.005603094,0.041773055,-0.024352266,0.033012718,0.054652203,-0.11692121,0.017438922,0.0017829817,0.020983664,-0.029014826,0.023869228,0.00041508622,-0.06625601,0.043793272,-0.0028648903,-0.0011176973,0.06184118,0.008028347,-0.10571008,0.02163245,0.0062938416,0.02028934,-0.09914804,0.0075748162,0.017665802,-0.06207695,-0.08794658,-0.053001326,0.077135354,-0.018559381,-0.08541741,0.06371855,0.015848821,0.10687711,-0.04759361,-0.018582184,-0.058420654,0.005949004,0.0098389005,-0.018152906,-0.006943886,0.07366207,-0.008535799,-0.041094292,-0.020261472,-0.059300695,-0.030345611,-0.053632457,0.024533143,-0.080584556,0.009126526,0.009757808,0.08519502,-0.0041625635,0.05838147,-0.029883808,0.0134254405,-0.023713127,-0.005408092,-0.0062425337,0.06459458,0.030978924,-0.028857503,0.0017425747,-0.07171604,-0.028261287,0.07575133,-0.08295031,0.039596003,-0.00017224862,0.00015296947,-0.03888554,-0.015888616,-0.0291418,0.096467614,0.04391547,0.071706995,0.043224577,0.020104958,-0.03993955,-0.008107018,0.030481396,0.024536187,0.06308681,-0.005357267,-0.0098109655,0.042945396,-0.018169725,-0.030943606,0.07179693,0.0037360003,-0.03402474,-0.05868184,-0.04723663,-0.019222401,0.048407905,-0.083618954,-0.0677119,0.04901488,0.03430834,-0.011105628,0.071964785,-0.042494174,-0.02764127,0.022764767,0.03283511,-0.017540384,-0.045765005,-0.0066219186,0.0030571811,-0.0092487745,-0.012143364,0.01358745,0.0044349795,-0.011231129,0.11396823,0.08654758,-0.05645908,-0.0045723626,0.0020576837,-5.7632266e-34,-0.0115272,0.02793878,-0.061232682,0.008606888,0.04224965,-0.017017828,-0.096477434,0.024011316,-0.013122833,-0.022292398,-0.15145898,0.040060386,-0.014678352,0.036623374,-0.0072933664,-0.03117646,0.060602397,0.04903852,0.031218126,-0.039274473,-0.05722312,0.083858535,-0.061750278,0.0016926995,-0.058968507,-0.013240949,0.012017935,-0.012638491,0.00802535,-0.026605055,0.0684513,-0.03683031,0.025401989,0.08758159,0.061375167,0.021877283,-0.03129433,-0.02775344,-0.005557977,0.08219766,-0.022609653,0.055645913,0.0016524579,0.014723996,-0.058186986,-0.0074104564,-0.053338572,0.054076374,0.028595662,0.020672934,-0.006124015,0.02054524,0.04572749,0.05331571,-0.036801226,-0.026229637,0.027997687,-0.0030294068,-0.017165277,0.09190242,-0.10340211,0.016907742,-0.050006602,-0.081248775,-0.05400371,0.00826957,-0.099541426,0.00743252,0.019538801,0.04134972,-0.11295262,0.05334473,0.12266923,0.023448218,0.09143893,-0.078385696,-0.082404174,0.015431778,0.026056847,0.044565227,-0.036454976,-0.057785124,0.05430678,0.084569916,-0.058303777,0.0641845,-0.052808527,0.033934858,0.013950176,0.069832675,0.062470082,0.014969968,0.007541569,0.007700217,-0.031224044,-1.0433635e-33,0.06386251,-0.046796888,-0.0418466,-0.006738717,-0.040304452,0.041465916,0.056344964,-0.047154352,-0.028000593,-0.07954981,0.12579183,-0.0058212383,-0.0027779764,-0.013948315,-0.06274644,0.09143067,0.013767002,0.1373539,-0.0964064,-0.073127486,-0.0541657,0.06446151,0.017257368,0.033258613,0.10574037,0.0058560283,0.04781313,-0.0029499268,0.014116321,0.06875906,0.023218596,-0.008648152,-0.089655586,-0.06682591,0.03076276,0.06590578,0.008932635,-0.020254271,-0.09144062,0.009739255,0.06730314,-0.033371404,0.08235518,-0.0112504745,0.039443206,0.04606063,-0.09029471,-0.0011592326,-0.10083271,0.065264024,0.05180073,-0.035555616,-0.0038128276,0.013766772,-0.006567454,-0.02062923,0.01445881,-0.05314628,-0.023225168,-0.034992736,-0.016454654,-0.031677943,0.026944082,-0.06255091,-0.0008182756,-0.050090756,-0.03903744,0.033078898,0.064549506,-0.0009333539,0.116887555,-0.09426613,0.0065739336,0.031833097,-0.048148718,-0.024157401,0.02252286,-0.06965669,0.011300074,-0.0696275,-0.02583673,0.030799601,0.0045982813,-0.11683497,-0.036900003,0.05076576,-0.010604032,0.03986739,-0.013460043,0.036097866,-0.00012515912,-0.005695694,-0.06434051,0.0804282,0.045316543,-1.7050688e-08,-0.047010023,-0.040123396,0.008062139,0.0373118,-0.03493547,0.033467297,0.066584,0.07006712,-0.04080504,-0.027502293,0.0028583363,0.10056436,-0.009038134,0.008230127,0.03725258,-0.005305145,0.014330855,0.035922866,-0.020541333,-0.00754424,-0.083357945,-0.0029277506,-0.044089682,0.0626707,-0.011043725,-0.10730242,-0.0014930144,0.09987752,0.1395072,0.008910974,0.0150608,0.0049671144,-0.04543066,-0.0050016013,0.036765944,0.11708137,-0.05641455,-0.0065856343,-0.03742894,0.030843051,-0.073008284,-0.042724855,-0.001648286,0.025764992,0.052866034,-0.045718066,0.022541268,0.030428497,0.010055975,-0.032554384,0.08296558,0.005537069,0.0033682464,0.011684571,-0.06851044,-0.046372414,0.022321047,-0.03819557,-0.03349806,-0.07879361,-0.0035793926,-0.044486143,0.16138873,-0.017875604 +3.1.1.24,The enzyme acts on the product of EC 4.1.1.44 4-carboxymuconolactone decarboxylase.,384,0.99999994,-0.000228332,-0.01302604,-0.0037978985,-0.06861832,-0.026030488,0.028553672,-0.12358763,0.005451744,0.023600632,-0.028499017,0.014577785,-0.084993444,-0.09615293,0.030571053,-0.039195918,-0.018998105,-0.052979846,-0.0012320299,-0.03075389,-0.011877008,0.019589424,-0.012750782,-0.04608543,0.00680794,0.06321971,-0.015186161,0.039249785,-0.06562244,-0.005089103,-0.10387614,0.05122129,-0.071890436,0.06516388,0.0074919416,0.031283196,0.06583373,-0.045481794,-0.14423169,0.042235628,0.047816534,0.03044381,-0.020854268,0.0010731014,-0.048981372,-0.032509428,-0.011651355,0.025581338,0.018748272,0.03533826,0.0027059305,0.03478384,0.0053277854,-0.011693538,-0.0061848545,-0.082555376,0.003370382,-0.031983055,0.043261997,-0.062354997,0.06973447,0.11986837,0.041079007,0.00096044183,-0.010280967,-0.015733274,0.023640655,0.02914109,-0.039909422,0.0060182516,0.009089457,-0.043841716,-0.06617588,0.01828811,-0.0013328909,-0.012146758,-0.031011647,-0.0464377,-0.08301034,0.0799832,-0.006945304,0.02260821,0.023666704,0.036340766,-0.051412296,0.01934325,0.015422921,-0.008739825,-0.0045623393,0.059631184,0.025317617,0.05117013,-0.10063123,-0.006437111,0.053213224,0.008667713,0.056709122,0.009610365,0.06553268,0.015739292,-0.037535958,0.027312804,0.0037394394,-0.07995405,-0.069557205,-0.041109562,0.04345606,0.02286509,0.03011394,-0.027436186,0.031653363,-0.04684309,-0.054667227,0.049514584,0.019762984,-0.06769515,0.09009305,-0.0014001392,-0.029504899,-0.0051861946,0.006669794,0.0718439,-0.048971325,0.03373877,0.06604643,-0.021527335,0.056508042,-0.113629945,-7.3868345e-34,0.029055003,-0.018212847,0.06893092,0.009252871,0.024913857,-0.0091774715,-0.08987424,0.09616766,-0.13221148,0.0034449291,-0.04457158,-0.0022460725,0.053228088,0.0044088312,-0.058836084,-0.04884606,-0.043819737,-0.010206994,-0.021611067,-0.0288378,0.029423578,0.06644349,-0.087790884,0.10678385,-0.04616512,0.02165087,-0.019624222,0.018242259,0.07207563,0.008218486,-0.08172927,-0.1101041,-0.08830306,0.023028942,0.034276847,0.02443599,-0.026025536,-0.057167824,-0.05060697,0.03818576,0.06898393,-0.031219373,-0.016295537,-0.096373215,0.04044136,-0.03211602,0.0021463905,0.04902231,0.048357062,-0.0014960292,0.06840096,-0.021958556,0.057448428,-0.009432594,-0.0027769927,0.056536682,-0.110288255,0.0139393555,0.05349122,0.023269812,0.004569055,0.0543797,-0.0009284922,-0.03004405,0.010332816,0.024485245,-0.0832283,-0.04001646,-0.057892922,0.06843331,-0.03590136,-0.040031448,0.061533283,0.029959872,0.12190112,0.012060179,-0.060849935,0.041411422,0.020941237,-0.0107296035,-0.06485817,0.045540944,-0.018303467,-0.053719793,-0.017642856,-0.012265196,-0.026265977,0.00027573423,0.02989068,0.1080679,-0.011635993,-0.07323679,-0.027158998,0.081286244,-0.007342009,-1.7072019e-33,0.05375719,-0.10393881,0.021050487,-0.0076112812,-0.0008011395,0.0725306,0.0318136,0.00015858984,0.048819203,0.044148624,0.083273575,-0.013226524,0.011786234,-0.03129881,0.053462166,0.039970115,0.012732182,0.00025493142,-0.029823527,0.016638545,-0.018161206,0.08629234,0.012526542,0.035160597,0.021664934,-0.041093502,0.039772496,0.084552884,0.095504485,0.027671818,-0.047411352,-0.0073844735,-0.019150205,0.018613296,-0.13364929,0.047366027,-0.046430685,-0.038897842,0.03825657,0.002211574,-0.0510028,0.0017303133,-0.021387557,0.11838448,0.08450625,0.035312913,-0.037659347,0.03256769,0.039137367,-0.043444548,0.011743208,0.004293169,-0.0056943363,0.014538718,-0.014013962,0.114536084,0.009014567,0.01226614,0.014754447,0.024511695,-0.021901852,-0.060325347,0.065182835,-0.044203456,0.06607594,-0.04512152,-0.08223263,0.06851438,0.095401525,-0.042363834,0.07320713,0.042249795,-0.044590294,0.037303973,0.0033000438,-0.050138634,-0.07673457,-0.1029324,0.016979601,-0.08714702,-0.07839051,-0.012288071,0.034152023,-0.06443504,0.04147337,-0.081135675,0.04275551,0.12249673,0.001273492,0.07154003,-0.024484258,-0.045619607,-0.0436986,0.11546976,0.042368438,-2.7556286e-08,0.046588518,-0.008255269,0.029159313,-0.0922712,0.0027378679,0.071886785,0.032043856,0.022474444,-0.017388552,-0.08376167,0.0020588946,0.014289875,-0.047354896,0.053397477,0.04524545,0.019714486,-0.09402606,0.03674722,-0.0075624892,0.039485168,0.022062847,-0.009385168,-0.06795212,0.032779653,-0.05365543,-0.023000201,0.10552785,0.10926849,-0.04060366,-0.016688053,-0.032750357,0.076721705,0.027853679,-0.032316297,-0.07844517,-0.031722542,-0.058679175,0.028001882,-0.04208272,0.05270603,0.04833654,-0.06608923,-0.033551928,-0.0027986795,-0.038061704,0.018629473,-0.0156808,0.027465947,0.020653646,0.025701828,0.053835467,-0.016546384,-0.070666626,0.023922753,-0.0034864272,-0.018712068,-0.0496581,-0.085455514,0.024175609,-0.057642337,-0.030746754,0.00787834,0.16030844,-0.04832666 +3.1.1.25,"The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+.",384,1.0,0.0609681,-0.12257036,0.0028440016,-0.03271371,0.01467359,0.056998614,-0.09714741,0.008801074,0.0020235793,-0.03647795,-0.0009017365,-0.10607042,-0.093091205,0.077414446,0.0045505394,0.014073498,-0.05975157,0.046161477,-0.039245225,-0.031459272,0.07219168,-0.03173557,0.0020247754,0.06900924,0.042787645,-0.025161406,0.011932331,0.009981356,0.04700167,-0.09719598,0.000170713,-0.07603928,0.004299076,-0.03600665,0.02284726,0.0796197,-0.04085121,-0.033304892,0.037525684,0.0071181483,0.050418325,0.004417671,0.01349462,0.034119256,-0.00414105,-0.07352462,0.04900979,0.009214255,0.013908052,-0.0034440174,-0.033874042,-0.051598545,-0.03286542,-0.0121064745,-0.026658457,0.00662192,-0.04584139,0.02165952,0.01486694,0.033327684,0.058926847,-0.008793189,0.018796694,0.0025666167,-0.019884234,0.017857023,0.02165528,-0.105058804,0.015757315,-0.0012894886,-0.060593426,-0.113768354,0.016724115,0.08495764,0.011470639,0.035924923,-0.015303341,-0.060125627,0.0790846,-0.05108199,0.0038693117,-0.078952566,-0.020850405,0.088369794,0.06405048,0.007956371,0.042978756,-0.01715799,0.07550942,0.0361714,0.022876792,-0.0071021686,-0.017881429,-0.04398618,0.0022042245,0.013344641,0.062483728,0.011416925,-0.009114081,-0.03716254,0.07046926,0.030187156,-0.034100775,-0.050328124,-0.034020156,0.039066277,0.043895617,-0.03079047,-0.039201483,0.008077224,-0.016343728,0.014148451,0.02281415,0.009120744,-0.016049607,0.09570494,0.012201549,-0.08687732,-0.021919364,0.05309461,-0.047073867,-0.011888076,0.05015589,0.038380884,-0.025545742,0.020981036,-0.06515643,2.7249616e-33,0.043575834,0.055889778,0.03910219,-0.04517481,0.017826598,-0.008290346,-0.109180175,0.03381128,-0.08402061,-0.003056501,0.027039053,-0.04296326,0.032762133,0.015333713,0.05107607,-0.006394151,0.0149643915,-0.07350949,0.045597084,-0.028116178,-0.075217344,0.00530901,-0.099025786,0.09520334,0.018658811,0.035413124,0.019118777,0.06452206,0.08472636,-0.008410822,0.017318422,-0.09134659,-0.105682895,0.064298235,0.036250323,0.040692106,-0.0015407925,0.0062185293,0.027796855,0.037353966,0.01896446,0.04937786,0.059735868,-0.06687491,0.006264241,-0.0661881,-0.04689741,0.056678094,0.06842287,0.028394394,0.040174473,0.016419334,0.0009227041,0.013998521,0.0012918271,0.018345846,-0.07331811,0.07281732,0.013338872,-0.0137596335,0.0105039235,-0.034074727,-0.008781806,-0.0059052687,0.005277563,0.06127135,-0.029827895,-0.02369493,-0.028699784,-0.016083637,-0.059317935,-0.028871546,0.042278606,0.0079441015,0.0248944,-0.0093700085,-0.02937618,0.0017821426,0.04521921,0.02955406,-0.025342487,-0.0078798905,0.03656486,0.02461449,-0.101343185,0.027950324,0.016408352,0.020896016,0.024130072,0.043480195,0.0075964043,-0.045574863,0.012811035,0.03108749,-0.016671749,-3.679256e-33,0.022657864,-0.066669784,0.07666194,-0.046629805,-0.024726182,0.01840667,0.0819569,-0.10016479,0.098496296,-0.016469683,0.105303705,-0.03967798,0.047152985,-0.0815957,0.013713139,0.11721422,-0.07557936,0.049498156,0.08020704,0.014784855,0.06182189,0.10786479,-0.08250522,0.0833166,0.10371632,0.03423869,-0.04005692,0.036985412,0.08731059,0.023230517,-0.032535624,0.00017261146,0.018833213,-0.05104984,-0.13163246,0.002959844,-0.033377856,0.037137926,-0.045810945,0.10047154,-0.06989174,-0.008315302,0.016912522,0.044832572,0.02031737,0.059244763,0.013224172,0.012197386,-0.014323866,-0.0030675454,0.03229668,-0.023615241,-0.05462851,0.03294907,0.021954898,0.10251154,-0.019961784,0.03581675,-0.00973769,-0.051399644,-0.047090553,-0.014467745,0.010040655,-0.107918434,0.0023521616,0.041432574,-0.12804458,-0.06493047,-0.014238466,-0.04636252,0.06867542,0.018795934,0.014586286,0.042778403,-0.028055277,0.014338191,-0.04966794,-0.085687436,-0.06284587,-0.11613082,0.015149026,0.091604754,0.010050567,-0.033927865,0.017749058,-0.021770531,-0.009686206,0.05660105,0.018850312,0.06974945,-0.022166384,-0.04188362,-0.011053232,0.058999013,0.06157404,-3.796039e-08,0.011781165,-0.017945385,0.00407474,-0.065559804,-0.031945936,0.025509927,0.06427127,-0.056066494,0.06320003,-0.05430421,-0.05192202,0.0677418,0.0014786025,0.06927832,0.0013903583,-0.047921117,-0.014181425,0.021290079,-0.04710876,-0.02690105,-0.059730154,-0.021248195,-0.11916442,-0.0050354484,-0.00014122778,-0.013966069,-0.018927941,0.06885506,-0.047095,-0.0076936637,0.02949913,0.0727413,0.039228678,-0.11930057,-0.027072415,0.0734692,-0.030550197,-0.060707614,-0.07118923,0.03596544,0.03744283,-0.09037147,-0.04827234,-0.00020187264,0.023561621,-0.024084946,-0.042245604,-0.04040512,0.06032012,0.056991566,0.0476274,-0.021338172,-0.02684179,-0.060476717,-0.043899793,0.02554505,0.013018255,-0.048149724,-0.05262922,-0.0862151,0.051303595,-0.033592474,0.20314486,-0.16251662 +3.1.1.26,"Also acts on 2,3-di-O-acyl-1-O-(6-O-alpha-D-galactosyl-beta-D-galactosyl)-D-glycerol, and phosphatidylcholine and other phospholipids.",384,1.0,-0.041403085,-0.11989507,-0.0645526,0.02868854,0.02837985,-0.014641392,0.031932306,-0.01776113,0.07020412,-0.008787699,0.06214718,0.032462575,-0.10093991,0.051025677,0.035522092,0.055518445,-0.037982047,0.042635556,-0.027301155,0.024513248,0.042012308,0.018335612,0.013996684,0.040426634,-0.008268578,0.0075482437,0.015674558,-0.023838904,0.012197114,-0.11019652,0.008230216,-0.05645426,0.060041253,-0.0021850483,0.009029895,-0.0041410103,-0.0043734848,0.026524771,-0.043886084,0.047466107,0.08032926,-0.05655842,0.039502442,0.024130099,-0.018601097,0.0026176402,-0.08402397,0.056266848,0.069392346,0.046916656,-0.009542675,-0.08443819,-0.10132096,0.055994768,-0.018459078,0.09987319,-0.11066207,0.012776481,0.014707598,0.03937565,-0.024067981,0.023308467,0.051918693,0.11043444,-0.05449987,-0.030465413,0.03952259,-0.053544942,0.014428953,0.008575472,-0.018744228,-0.09865959,0.023863133,-0.060818963,0.057112355,0.053583533,-0.0014488167,-0.045757093,0.06701703,-0.116169296,0.036461025,-0.04518501,0.022154244,0.09619768,-0.025280954,-0.00854829,-0.037241116,-0.04440859,-0.010678911,0.0064395685,0.017908534,-0.09761742,-0.039724585,-0.0071527027,-0.060027413,0.012884467,0.07321161,-0.035545778,-0.016721362,0.01534954,-0.041650984,0.010213899,-0.019224085,-0.032306764,-0.019516548,0.03243308,-0.033188608,-0.07367498,-0.057639495,-0.0020497765,-0.012934621,-0.05937615,0.06069788,-0.024119694,-0.03396822,0.013803488,0.0074555515,0.0119212475,0.005744644,-0.0345288,0.01857791,-0.06253228,0.0023276152,-0.0016856453,-0.07521923,0.10109551,-0.029092535,-4.5452188e-35,0.083052024,0.024426542,0.0044080755,0.0083678225,-0.0029539752,-0.025854083,-0.09602907,-0.03726626,-0.03971972,0.009007218,-0.00978303,-0.062825315,0.069150314,0.09490466,0.020422976,0.029643161,0.04045956,0.02818436,0.07371332,-0.071385466,0.021719273,0.09031177,-0.04001673,-0.019018186,0.057342872,0.025548348,-0.03661708,0.046222392,0.05149235,-0.01041312,0.048182953,-0.087180056,-0.08197043,0.041302897,0.027497118,0.11075752,-0.078376435,-0.072663076,0.039366204,-0.011772622,0.0011713575,-0.019945594,-0.094349205,-0.033791665,0.012097002,-0.010974604,-0.06721733,0.06380791,0.08619177,0.019073965,0.036669932,-0.047601733,0.068918,0.046380766,-0.009064507,-0.008013926,-0.06634587,0.0057509574,0.022884425,0.010452597,0.0023659673,0.041704252,-0.06067535,-0.012594839,0.05225906,0.035886362,-0.072178684,-0.036464747,-0.08348218,0.0098181525,-0.0011395486,-0.02674425,0.05030793,0.004064197,-0.005824655,-0.027918851,0.053083785,0.011317576,-0.027463742,0.022947056,0.026047267,0.014749704,0.08310111,0.034792695,-0.050933562,0.034949914,-0.03596234,-0.048693813,-0.017203009,0.008680013,-0.048435986,-0.010365721,-0.021868486,0.036513876,-0.007932129,-1.9876678e-33,-0.003163407,-0.0737644,0.112079,-0.04077479,-0.030354226,0.09470053,-0.013971169,-0.014158235,0.11032491,-0.031396158,-0.0037858617,0.013282882,-0.02205688,-0.10231074,0.019229295,0.01662862,-0.04600027,0.05817985,0.008281421,-0.035657767,-0.019425463,0.040042456,-0.019805538,0.1349618,0.028307525,-0.016619908,0.013717224,-0.049265902,-0.016578587,0.089135125,0.03463783,-0.012551415,-0.036959305,-0.020285193,-0.021171479,0.031816106,-0.053871494,0.029946893,-0.07332957,0.024090936,-0.04495628,-0.007466881,0.18921529,-0.026316645,0.08210939,0.08409734,-0.014885129,0.04410858,-0.06540601,-0.02214169,-0.047253698,-0.018258821,-0.05137206,0.089432515,0.0729695,0.118110344,0.037824184,-0.011429906,0.025515888,-0.107157245,-0.018681189,-0.029244972,-0.025135573,-0.034000095,0.0547643,0.016464178,-0.0133269075,-0.0381583,0.03849572,0.0041765,0.04233437,0.024113918,-0.055900544,0.008085595,-0.01324844,-0.0003152977,-0.047440417,-0.0859926,-0.004951118,0.028817462,0.04109145,0.042871863,0.040076878,0.0025868407,-0.014029817,0.027170088,-0.0038577472,0.111393906,0.029210135,0.034892906,-0.023785282,0.011699714,-0.05016082,0.020124385,0.035260275,-3.9389207e-08,0.118568696,-0.020006528,0.067922875,-0.12391779,-0.07022388,-0.014042874,0.0807058,0.0459232,-0.03675499,-0.031939343,-0.032371167,0.10487704,0.05295023,-0.051734485,0.0590204,0.03712524,-0.02894639,0.051434293,-0.046527524,-0.06433711,-0.017103652,-0.018029522,-0.010446546,0.0399239,-0.022779454,-0.07356856,0.08261913,0.029798623,-0.040655304,0.03383592,0.05559426,-0.025530707,-0.031603694,-0.085223325,0.015154266,0.0003651537,-0.020310864,-0.061968274,-0.010183292,0.09279928,-0.003857533,-0.015039003,0.04842591,0.040960383,-0.046311762,-0.014807242,0.0067400313,-0.027152328,-0.050204676,-9.730272e-05,-0.032810718,-0.016292727,-0.05840109,-0.052733652,-0.17831077,-0.039995026,-0.03295415,-0.02665137,0.014148962,-0.07920703,-0.0027819034,0.01352572,0.15511252,0.039520424 +3.1.1.28,Acts on higher fatty acid (C6 to C18) esters of L-carnitine; highest activity is with O-decanoyl-L-carnitine.,384,1.0,-0.0748678,-0.079807915,-0.032760605,0.025391608,-0.008221948,0.053897873,-0.06107936,0.0679814,-0.008229302,-0.052628078,-0.021003956,-0.054446764,-0.10076194,0.002369511,0.016732866,0.028012915,0.027376622,0.018189296,-0.0504858,0.0019775396,0.03536148,-0.018679589,0.034210455,0.07303233,0.03482337,-0.0065256734,-0.027150346,0.024531363,0.02578083,-0.07995208,-0.0015108524,-0.075286575,0.1236009,-0.01865284,-0.03387752,0.02250966,-0.06716794,-0.076599665,0.06647039,0.056623682,0.011835746,-0.075398564,-0.025530154,-0.047002487,0.0500818,-0.033382986,-0.06407584,0.034788057,-0.009906486,0.01104806,-0.03386743,-0.049701266,-0.07997736,0.038858905,-0.05461076,-0.013573795,-0.089579165,0.023398668,0.032482438,0.091421105,-0.01174232,0.04210106,0.026366908,0.0015756051,0.008463295,-0.060755115,0.009351285,-0.025774457,0.030579858,0.016161,-0.011870522,-0.08102784,-0.00239892,-0.018438138,-0.03987556,0.02499717,-0.03358308,0.037502855,-0.0053916867,-0.09424797,0.09205762,-0.038258266,-0.051615786,0.0964316,0.011985907,-0.034837738,-0.09025866,-0.038393527,0.031077348,0.124115,0.06861656,0.02271399,-0.08027942,0.041478418,-0.07519514,-0.022950536,0.08293225,-0.036249354,-0.009492327,-0.0050939186,0.042350974,0.031153351,-0.07267048,-0.054471478,-0.0523084,-0.0018202931,0.0011303526,-0.0062478776,-0.02331547,-0.033052526,0.01875125,0.0021598449,-0.036294147,-0.027318392,-0.11208472,0.06516521,0.007374325,-0.029399093,0.0077308966,-0.0049104146,-0.022778329,-0.055225357,0.055667374,-0.0023669822,-0.01845129,-0.007470376,-0.05043063,4.193456e-34,0.018495832,-0.006804258,0.00090596394,0.061545353,0.046723243,-0.022535095,-0.114336975,0.05006302,-0.00337082,-0.06973255,-0.043547064,-0.006055186,0.0257726,0.11027872,0.0290008,0.0061684847,0.026079409,-0.020117244,-0.006848226,-0.076291904,0.039692845,0.014445455,-0.023226127,0.023819178,0.007437977,0.044969257,-0.018512838,-0.018040469,-0.035274062,-0.012964453,-0.013391671,-0.037906762,0.03325758,0.033974547,0.10187197,0.09179592,-0.03400404,-0.047329172,-0.042654507,0.043295026,0.071132764,0.042880077,-0.023921024,-0.024740493,0.008221877,0.020925848,-0.051021,0.062402327,0.050458085,0.0036633108,0.09650622,-0.06660504,-0.016860303,-0.0013408196,-0.03339461,0.09858608,-0.07743462,0.03957777,-0.011658237,0.022119468,0.06776819,0.06476579,0.00024579806,0.015354583,-0.012216717,0.036676977,-0.1299431,-0.040034816,0.015390637,0.025199078,-0.023223931,-0.009567096,0.1805559,0.0056866514,0.101985544,0.07879501,-0.07131191,0.03448982,0.011407145,-0.035995685,0.04566982,-0.022055337,0.04146367,-0.049950395,-0.057636157,0.0540604,-0.050375976,-0.034448802,0.0775121,0.09450451,-0.047254585,-0.073904164,0.023484707,-0.016551364,-0.018762551,-2.2692004e-33,0.10135683,-0.08102548,0.068101905,-0.0015630524,-0.009486971,0.05758867,-0.030709676,-0.1523418,0.047711983,0.004589006,0.06429833,-0.017858671,0.061901648,-0.031498145,0.062440872,0.03576535,-0.016066274,0.051082358,-0.068316706,-0.009331629,-0.04535475,-0.04503672,0.006860324,0.09041732,0.08232891,-0.0015327121,-0.043500636,0.03362248,0.13587411,-0.022592757,0.0095409965,-0.010751697,0.0087686125,-0.06990668,-0.044122662,0.08904429,-0.041055974,0.015022235,-0.009782441,0.03388328,-0.002151109,-0.073058344,0.03794124,0.03527774,0.0451364,-0.05895019,-0.037588846,-0.079475425,-0.031227505,0.0012754634,0.10815475,-0.069994375,-0.035689086,0.047156747,0.089724235,0.09923154,-0.018591385,-0.07503329,-0.018127963,-0.041539118,0.048548855,-0.010265392,-0.07322972,-0.023142777,0.017992826,-0.0063035865,-0.052419033,-0.008610616,-0.006009486,-0.035140097,0.0988635,-0.0141834775,0.031631712,0.03130303,-0.09440555,-0.044199254,0.03258951,-0.10372472,-0.0018551808,-0.08295405,-0.053674012,-0.009251469,0.01035031,-0.028657276,-0.06284488,0.054351714,-0.0562452,0.04495715,0.026659893,0.041650873,0.0021365013,-0.025086392,-0.026688032,0.012633241,0.02875607,-2.8223736e-08,0.067120746,-0.05861647,-0.011906305,0.009904125,0.006759409,0.0037254256,-0.006877964,0.011525498,-0.027349243,-0.072157174,0.005420073,0.06237853,0.046936907,-0.049571313,0.020094104,0.0010186688,0.002573806,0.0595755,-0.0037615653,0.03752521,-0.07246933,-0.016186174,-0.0046744756,-0.044164382,0.022850424,-0.11619012,0.0032455844,0.12539683,0.05542235,0.03171864,0.03264149,0.0028927242,0.055311095,-0.034633577,0.07205551,0.021990666,0.008044583,-0.03120773,-0.10674733,0.10293764,0.060872238,-0.047932643,-0.04835914,0.0361331,-0.03231999,-0.02107864,-0.058169354,0.024336435,-0.0077938125,0.058672886,0.014698718,0.018378818,-0.03879851,0.033094663,-0.042457018,0.018608116,-0.04418008,-0.006733608,-0.039889596,-0.038153693,0.02135581,0.022792425,0.1309414,0.030360127 +3.1.1.29,"The enzyme acts on premature protein synthesis products that dissociate from stalled ribosomes, cleaving the peptidyl chains and restoring functionality to the tRNA. In most organisms mutants with limited Pth activity accumulate peptidyl-tRNAs, reducing the availability of uncharged tRNAs below the limit that is necessary for protein synthesis and impairing cell growth. Two distinct classes of the enzyme, Pth and Pth2, have been identified. While most enzymes can recognize and cleave N-acylated aminoacyl-tRNAs, they are not able to act on N-formyl-methionyl-tRNA.",384,1.0,-0.025228202,-0.124141335,-0.055134773,-0.06336481,-0.027993158,0.008236234,-0.05956946,0.012334877,0.0427665,0.0033341227,0.043611903,0.010420551,-0.033424504,0.062887326,-0.046669357,0.020277359,-0.074031316,-0.068096645,0.049842183,-0.060342632,0.014828658,0.11252131,-0.072690554,0.010615629,-0.03355652,-0.045841504,0.06948753,-0.032674942,0.01207601,-0.08208345,-0.08962351,-0.046499282,0.0021434359,-0.015474929,0.036545787,0.07573362,-0.02564315,0.013945958,0.06767561,-0.007743343,0.047310796,-0.04380703,-0.029042799,-0.07954874,-0.007901005,-0.0521768,0.065193295,0.081514545,0.023539882,0.010329205,-0.06888553,-0.043634217,-0.007967627,-0.021193692,0.030828705,0.102650374,-0.048787512,0.036404334,-0.016391203,0.004253281,-0.013442508,-0.012547273,0.012165967,-0.08323597,0.0755763,-0.047928277,0.013735847,-0.018763086,0.053155016,0.03762714,-0.02186559,0.005526104,0.012601853,0.049142607,-0.022913458,0.011027364,-0.014382741,-0.056518476,-0.023375673,-0.02522431,-0.04864297,-0.0365353,0.02437347,-0.00024263619,0.030695774,0.050620295,0.02713667,0.053821534,0.039344747,-0.051057465,0.056832105,0.022019332,0.04798162,0.018593077,-0.0426923,0.052946497,0.012445844,-0.009021528,-0.009094999,-0.05838493,-0.02188534,0.024959058,-0.0137359155,-0.035735946,-0.030127652,0.011631234,0.013333186,0.041870818,-0.017492361,0.010325236,0.0635808,0.031681348,0.04189084,0.036511056,0.006148736,0.083141774,-0.059205193,-0.10400349,0.058238573,-0.017702334,0.013411099,0.041684806,0.042643145,0.10923771,-0.08710251,0.09896582,-0.017242093,3.3382467e-33,0.026012577,0.016889175,0.012663532,0.075755045,0.032711457,-0.017001707,-0.06024289,-0.019817919,-0.034952696,-0.04395177,-0.021294683,-0.07734374,0.037395015,-0.04910904,0.007572348,-0.032582764,0.0018834099,0.07729205,-0.029990973,0.055085592,0.01246547,0.086497016,-0.008122792,0.026219497,0.041558154,0.04835169,0.0061584334,-0.012168181,0.055455793,0.0062275524,-0.033158578,-0.03423919,-0.04975653,0.03573879,-0.008929207,-0.03129766,-0.020160636,-0.0061335405,0.013130849,0.020330328,0.03117961,0.00088717433,-0.023296874,0.0014340198,0.0049822265,-0.036648896,0.005190474,0.026500685,-0.16151312,0.008677267,0.06272722,-0.052859128,0.041572783,-0.027490344,-0.0680763,-0.028460383,-0.06402096,-0.06316274,0.12916778,0.080249175,0.03477946,0.0046237935,-0.06638375,0.10422453,-0.07211178,-0.024201093,-0.04821076,-0.06347556,0.01992942,0.16229789,-0.00022651232,-0.03600746,0.045734957,0.059323076,0.06671275,-0.08013926,-0.05236799,0.0055533834,-0.0015346385,0.061504725,-0.0048651895,-0.036439426,-0.027721805,-0.016339254,-0.00081352564,-0.0638152,0.009748119,-0.0557133,-0.035805654,0.036806986,0.04182297,-0.017396703,-0.07040756,0.055965792,0.0064410754,-4.4712392e-33,0.1067408,-0.09169133,-0.00075409224,-0.056439113,-0.14585002,0.0737916,-0.04329214,-0.08060523,0.027599761,-0.11991195,0.05985518,-0.016916534,-0.03928814,-0.030044949,0.022249976,-0.062300317,0.005398655,-0.007908614,-0.006434985,-0.011553421,0.0019358075,0.0060758,-0.04714054,0.0443569,0.03209968,0.0009795422,-0.03239032,0.10685696,0.044271946,0.076718055,-0.0109676225,0.04172906,0.0061288425,0.08762118,-0.043323547,0.06366891,-0.06773757,0.043512244,0.07453564,-0.03220216,0.029636929,0.0411965,-0.009348121,0.061885275,-0.047988243,0.03122405,0.002457707,-0.028715897,-0.08618556,-0.0971104,0.096141,-0.07289296,0.07025401,-0.0309506,-0.02782134,0.061243184,-0.033293,0.003115256,0.047673307,0.028927619,-0.015010646,-0.09379349,-0.012761206,0.055556625,0.023756,-0.022610687,-0.038939342,0.034695864,0.044384483,0.057010762,0.011274807,0.08917307,0.047381897,0.050979577,-0.012112446,0.012769157,-0.09641169,0.0155187575,0.028962813,-0.10112299,-0.09404721,0.026407938,-0.011977145,-0.06820441,0.010158765,-0.0012944622,0.042615518,0.11883309,0.020780252,0.1289331,-0.011767988,-0.06055491,0.004161199,0.007762615,0.047636166,-4.3943626e-08,0.03331003,-0.013976994,0.03407354,-0.04492664,-0.03702986,0.032940477,0.013477184,-0.0045193764,0.07950131,0.0004982611,-0.10531472,0.013952227,0.048120875,0.084169604,-0.06059476,0.1323662,-0.05053485,-0.01745788,-0.002415928,-0.009804499,-0.10047723,0.04452948,-0.12304602,0.015161492,-0.029183395,-0.022023385,0.043919347,0.06659536,-0.0034689354,-0.07141825,0.0064716423,-0.00023046862,0.0009408489,-0.02108679,-0.02820323,0.016869674,0.024894964,-0.045978937,-0.03867104,0.0674698,0.02288004,-0.023799475,-0.045951087,-0.06610255,-0.024561726,-0.046981256,-0.023779001,-0.041818604,-0.012172539,-0.00075715606,0.07239878,0.057750426,0.0048684427,-0.070456855,-0.08588833,0.06589123,-0.018062597,-0.06793662,-0.0452464,-0.011859291,0.014798267,0.01582859,0.102634594,-0.02235691 +3.1.1.32,This enzyme has a much broader specificity than EC 3.1.1.4 phospholipase A2. Requires Ca2+.,384,1.0,-0.012049946,-0.1108308,-0.040479835,-0.028212037,0.08545417,-0.03830064,-0.06992762,0.03292351,0.069499366,-0.024183074,0.03996674,-0.08728437,-0.07542604,0.059403624,0.06320073,0.005224268,-0.0035480056,-0.013103988,-0.019893296,-0.089116514,0.08751767,-0.0059373938,0.01802117,0.058216076,0.026883906,-0.0036805316,-0.019068997,0.02609286,0.005037895,-0.057935823,-0.055949967,-0.056881048,0.06477807,-0.08007923,-0.0068309857,0.053542133,-0.08824907,-0.07541013,-0.060114622,-0.01111622,0.08182765,0.014429337,0.031851448,-0.05451968,-0.0038871763,-0.0003938977,0.007007923,0.011439153,0.03678812,-0.015871596,-0.047534764,-0.0681149,-0.051962573,-0.0028351587,-0.052660152,0.028651595,-0.1327108,0.07522354,-0.010394482,0.02142773,-0.038019706,-0.03088168,0.09346224,0.03297965,0.057557017,-0.006472124,0.011667569,-0.14368607,-0.015670039,0.03853079,-0.11568205,-0.065157495,0.02319479,0.079727024,0.075016156,0.08164918,-0.010549784,0.015157263,0.015878052,-0.087176755,0.07754831,-0.026181355,-0.039183002,0.09936669,0.031027576,0.03582796,-0.010428711,-0.042937964,-0.02933878,0.016698733,0.083902396,-0.026985254,0.09436955,0.061879326,-0.0032725262,0.044070292,-0.03855447,0.08265743,-0.030631034,-0.03871613,0.0032443784,0.10595658,-0.07021749,-0.022167346,0.011101,0.01911398,0.004702158,0.01776603,-0.033750974,0.036614146,0.08326471,-0.07664453,0.038974788,-0.042355984,-0.024952276,0.1214266,-0.011084963,-0.07185272,0.035372693,0.034380954,0.038731676,-0.11719024,0.007022477,0.002163243,-0.08489895,0.027598338,-0.0891886,1.3590881e-33,0.009609759,0.07431905,0.019011727,-0.0335716,-0.017072158,0.012620482,-0.05096035,0.020993395,-0.020843484,-0.10303509,-0.04086579,0.006261035,0.013248428,0.039041393,-0.00037006923,-0.00055423693,-0.009404405,0.025715152,-0.011207967,0.00047869864,0.099415645,-0.06328881,-0.070066385,0.029546252,0.06017905,0.024035307,-0.05457278,0.01862515,0.015111366,-0.003911901,-0.020422045,-0.069260426,-0.073001295,0.03721049,-0.038723916,0.000538734,-0.0030070562,-0.07359504,-0.031314358,0.030679317,-0.068421654,0.06346736,0.017600713,-0.055278655,0.07863774,-0.10172604,-0.0877063,0.084995255,0.054550298,0.06536929,0.01146586,0.001558424,0.101304464,-0.021462405,0.035266645,-0.026255956,-0.040474396,0.04501555,-0.022689156,0.0028389916,-0.0036413479,0.07892155,-0.03475352,0.035860684,-0.046340764,0.08378867,-0.069364466,-0.04165434,-0.058671407,0.019515019,0.0020629263,0.031046476,0.04019294,0.035466857,0.0046378006,-0.06730994,-0.010731074,0.023978885,0.014453388,0.018387508,-0.05361653,-0.019696489,0.0360862,0.044308342,-0.08857362,0.020946102,0.063987516,0.021375788,0.017897831,0.032802787,0.044436388,-0.02825108,0.004293288,0.1064097,-0.06855541,-1.64205e-33,0.03823496,-0.027126065,0.031243684,-0.029474499,-0.043637823,0.06682966,0.017251696,-0.04731295,0.14154041,0.008062477,0.057643596,-0.0025837268,0.06456928,-0.08760983,0.07869814,0.026814375,-0.068991646,0.021287803,0.022966752,0.029442802,0.053127836,0.10538895,0.0006412435,0.11937804,0.022073204,-0.031687442,-0.032692835,0.032655094,-0.011787622,-0.0038663058,-0.121117525,0.019092117,-0.02201945,-0.025716422,-0.07215275,-0.015780587,-0.016010439,-0.05881218,0.03431068,0.033626974,-0.013200847,0.036253694,0.0012133277,0.010541841,0.027624497,0.06773198,0.038223706,0.09551295,0.00013101113,0.009121298,-0.029028684,-0.009659526,-0.0225267,0.05460438,0.03223537,0.07253999,0.0076968092,0.1066231,-0.087254964,-0.00672696,-0.05298674,-0.04327324,0.03224537,-0.01332289,0.06959336,0.042289585,-0.08429983,0.021268176,0.009893275,0.047943093,0.041875,-0.010654878,-0.033934925,-0.024408,-0.014083683,-0.0151810665,-0.058916923,-0.023104483,0.017672818,-0.08440531,-0.019592961,0.057156455,0.058651257,-0.023525113,0.059155855,0.03581602,0.013216984,0.039733205,-0.036537066,0.06939685,-0.010305155,-0.06151365,-0.058282938,0.04312081,0.027919704,-2.6215204e-08,0.10531133,0.023716146,-0.008040441,-0.045597505,0.03594412,0.00041908998,-0.010650734,0.025613671,0.011649901,0.025612704,-0.06390252,0.011880398,0.036006894,0.0025818504,0.0663415,0.030988062,-0.027185349,0.018527303,-0.034774207,-0.019779239,-0.020510914,-0.038426492,-0.09874328,-0.0257375,0.037376847,-0.01652472,0.013248015,0.035764094,-0.051204283,0.007672111,-0.035401743,-0.02668446,0.017342564,-0.057916116,-0.03132686,0.008281012,-0.0305175,-0.017391402,-0.10143155,0.062233,0.010487339,-0.06929823,-0.014952748,-0.009364673,0.046996202,0.022612682,0.011987273,-0.045850173,-0.013560882,-0.03883999,0.0033727016,-0.09052681,0.023705311,-0.095223665,-0.058896627,-0.041180007,-0.021608269,-0.016307518,0.05656736,-0.048416324,0.09247967,0.047059733,0.14710042,-0.010153061 +3.1.1.34,"Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.",384,1.0,-0.056488868,-0.09715478,-0.084557936,-0.010386943,-0.0044634663,0.015696837,-0.025181394,0.01861547,-0.0007964483,-0.068103045,-0.016356729,-0.042321026,-0.09697155,0.013140957,0.010866207,-0.052057914,-0.00027604323,-0.07044567,0.002714902,-0.079376206,0.016651075,0.0006525481,-0.058290757,0.034875125,-0.0041489056,-0.03508823,0.07382884,-0.039130475,-0.023532731,0.007655725,0.08940128,-0.06199349,0.033584956,-0.051427606,0.048886187,0.055957373,0.018976666,-0.03412528,-0.06310259,-0.0133625185,0.08122032,-0.07712345,-0.08236661,-0.0067331116,-0.009517111,-0.026867442,-0.017405486,0.049905077,0.03855578,0.11425502,-0.027234882,-0.05510886,-0.02096208,-0.013693158,-0.039358865,-0.02428455,-0.036717016,0.02701289,-0.0021641415,-0.039052267,-0.07738659,0.0074598584,0.066063926,0.052005105,-0.038814425,-0.09389909,0.0054947725,-0.042191952,0.05985617,-0.038879886,-0.0013918501,-0.05912337,0.052941915,0.087397665,-0.060065515,-0.049259596,-0.06254701,-0.05415695,0.03812337,-0.061995175,0.051861346,-0.02945187,0.04075255,0.15672095,-0.024665346,0.030871445,-0.080444925,-0.035496548,-0.01382883,-0.027235305,0.034758717,-0.07669652,0.08904638,0.028901033,-0.08611909,0.006139734,0.01230856,-0.01713589,-0.043266937,-0.060875956,-0.010949953,0.002006552,-0.004895795,-0.056884326,-0.0009851774,0.11056445,-0.020457067,0.039841004,0.054606877,0.020954948,0.02880332,0.024569493,0.054308373,-0.031089908,-0.005740722,0.039300382,0.0037654198,-0.03529587,-0.060913257,0.014698169,-0.034998786,-0.029304123,0.12714347,0.048554488,0.053216778,0.054049335,0.046553537,5.6897967e-33,0.041959323,-0.05667462,0.03894669,-0.017847687,-0.09963783,0.0063688443,0.004454133,0.050836198,0.01980186,-0.071785204,0.029826537,-0.06415777,0.030523537,0.0851342,-0.060757615,-0.019620901,0.038383104,0.021201774,0.10414213,0.009412922,-0.030311856,-0.008021952,0.0006572189,0.004767949,0.05047108,0.07035494,-0.039390475,0.020581357,0.023233937,0.03372914,-0.025817702,-0.024022508,0.056601457,0.04293668,0.04419063,0.093074195,-0.048224017,-0.008527406,-0.016016224,0.07188024,-0.021255335,-0.068018146,-0.014523154,-0.12558064,-0.0035710463,0.0155803,-0.07400315,0.0608066,-0.03029602,-0.079747014,0.03882749,0.016659213,0.08321719,0.05895384,0.011901761,0.003546755,0.05816962,0.031869132,0.051856898,0.02126678,-0.0047385013,0.14301744,-0.055718224,-0.010756282,-0.01994476,-0.039354943,-0.06674518,-0.030043818,-0.07956359,0.038503665,0.000737521,0.058605637,0.05268849,0.052041117,0.06439607,-0.02752931,0.015362468,0.061996013,-0.0447637,0.05995231,0.008295665,-0.057768203,0.044808276,-0.011509558,-0.038670704,0.05106004,0.02579853,-0.03679512,-0.08636082,-0.005822916,-0.038615298,0.0007673728,-0.03155133,0.06648143,-0.025307704,-8.321628e-33,-0.03358541,-0.036354344,-0.008006134,-0.032571305,-0.008647531,0.031467233,0.027470794,0.0028825512,0.12523855,0.0020788873,0.06359043,-0.041207876,-0.054657593,-0.030728567,0.025762312,0.09477383,-0.06984912,0.05856121,-0.004955186,-0.06916053,-0.014267823,-0.037781127,0.013163371,0.09639591,0.04689879,-0.03542883,-0.059932336,-0.023012148,-0.012155738,0.10144699,0.026325788,-0.027291667,-0.05930586,-0.058332127,-0.00824404,-0.040304117,-0.13372359,-0.009985345,0.06474809,-0.044313673,-0.034619156,0.0420436,0.052428436,-0.016158039,0.049141757,0.03381744,-0.017031372,0.009473712,-0.007868474,-0.014293598,-0.04262721,0.025839113,0.032991633,0.15089676,0.010241522,0.09981127,0.07627384,0.036742035,0.060568582,-0.09913987,-0.095919564,-0.072710395,-0.00164222,0.061520096,0.015010431,0.03238096,0.028393362,0.0065241805,0.0058183335,-0.020646255,0.03442009,-0.021289732,0.020632375,0.093612775,-0.025957441,-0.009111317,-0.035363987,-0.027556764,-0.014220485,-0.06490127,-0.010415006,-0.0036076847,0.037514377,-0.1180941,0.017252758,-0.0526297,-0.061125997,0.011071094,0.022100758,0.06133916,-0.015958922,-0.0062032836,-0.07323875,-0.0924223,0.066378444,-4.5112497e-08,0.046921577,-0.101966165,-0.0018724494,-0.057683542,-0.015436549,0.053617675,0.011616409,0.001580614,0.033378642,-0.0625956,0.032657836,0.09444962,-0.03939539,-0.05430713,0.041973762,0.034590114,-0.021229543,0.0017196699,0.011163005,-0.038823593,0.041329373,-0.022113154,-0.030101886,0.04948551,-0.066147536,0.000790597,0.05210801,-0.015828127,-0.017556014,-0.01497207,-0.05296851,0.051450282,-0.04774388,-0.021600893,0.078452975,0.04305208,-0.0023758505,0.031246977,-0.029372264,0.11876418,-0.067997366,0.010760295,-0.05829665,-0.04210947,0.077392295,-0.014198461,0.001727819,0.015253892,0.007296672,-0.028456274,-0.059282124,0.0051324847,0.004469489,-0.043434918,-0.026381547,-0.026130527,-0.08656869,-0.055072907,-0.029711235,-0.07108107,-0.0008330386,0.04422985,0.16518955,0.030550193 +3.1.1.35,"Also hydrolyses some other benzenoid 1,4-lactones.",384,1.0,0.0020945368,-0.06742409,-0.0068674274,0.00022205696,0.034485597,0.034043077,-0.042962573,0.06820217,0.008958617,-0.11768219,-0.0016410991,-0.022067409,-0.06904649,0.020889837,-0.0654635,0.06325387,-0.039679978,0.10842759,-0.080180496,-0.013757568,0.0063393824,-0.003755973,0.029408524,0.07342543,0.054453097,0.025417792,0.049417693,0.04326802,0.028756358,-0.044661347,0.068347625,-0.010480843,-0.015144531,-0.0141423205,-0.0034644762,0.02835546,0.0021317045,-0.034173265,0.04686136,0.03561612,0.06140868,-0.07624968,0.029892664,-0.008273887,-0.003078774,-0.033116795,-0.0142927235,0.062379863,0.04827577,-0.007680361,-0.02591983,-0.03117927,-0.03105554,0.037911184,-0.10142121,0.0535941,-0.07123996,0.016853107,-0.0016376574,0.08292323,0.019977467,0.027478034,0.009096924,0.033430524,-0.015781065,0.024311481,0.00803857,-0.032181256,0.019294528,-0.009532334,-0.0027536189,-0.08951839,0.018580189,-0.024003085,-0.03639062,0.046907127,0.0049432125,-0.06134435,0.044408087,-0.066375986,-0.03777574,-0.0206921,0.010845024,0.07396634,0.0799616,-0.013805475,0.05860229,0.008609603,0.04216784,0.057920393,0.004053941,0.011482457,-0.016982011,0.018233333,-0.08364044,0.024638651,0.10147153,0.012970395,-0.004403484,-0.020095859,-0.040128715,-0.006612754,0.0011607393,-0.06473843,-0.053203493,0.031155046,0.076931655,0.037570853,-0.010637269,-0.06706361,-0.042549957,0.0071919435,-0.01881238,-0.0019451277,-0.052692905,0.06769016,0.054289475,0.005349505,-0.015318484,0.008441136,-0.042149846,-0.035278916,0.050301008,-0.023424638,-0.053622387,0.050647166,-0.011851174,-2.9256463e-34,0.033011697,0.036273394,0.036882542,0.026750037,0.026101239,0.03880587,-0.20068057,0.022915771,-0.018009817,-0.05159776,-0.033092126,0.027208002,0.00021645463,0.008365823,0.008253821,-0.057441816,0.0088963155,0.00026882443,0.033758953,-0.07596959,-0.039531056,0.031637345,-0.08618636,0.00043553583,-0.012413741,0.021784654,-0.0041519557,0.010488319,0.03240233,0.0138707105,-0.022930324,-0.026724441,-0.102598414,0.048677962,-0.07199274,0.12899016,-0.08369728,-0.056140095,0.03934741,0.05665677,0.007391492,-0.027520118,0.0009463779,-0.058888536,-0.03168837,-0.05130538,-0.10098532,0.026903853,0.019418173,-0.013221664,0.03688917,-0.02891543,-0.014619162,0.05219019,-0.042737693,-0.03507617,-0.0141760195,0.019125195,0.035179988,0.0032399336,-0.03132555,0.069311164,-0.025457367,-0.009305328,0.044122547,0.001850592,-0.05550689,0.008481529,-0.06583566,-0.053751864,-0.080991425,0.0027181616,0.13067716,0.01017251,-0.0011484775,-0.024688033,0.032136753,-0.050471354,0.032082662,0.091512635,-0.031747445,-0.09323865,0.012242776,0.008214948,-0.067929864,0.07970349,-0.008255557,-0.022685405,0.045486536,-0.01681345,0.020239193,-0.08469012,0.01969683,-0.033796724,-0.029515442,-1.4947785e-33,0.041977674,-0.085626855,0.051114615,0.0046889456,0.02414246,-0.014309339,0.03530296,-0.029680898,-0.0054170275,-0.025491767,0.10650735,-0.09594936,-0.041699585,-0.082044445,-0.034468412,0.03277873,0.082068436,0.030623132,0.012590336,-0.0056105736,-0.001913857,0.12129843,-0.029295765,0.102929786,0.046492122,0.013921755,-0.015300507,-0.035772752,0.008078066,0.10061206,0.019759584,0.039687496,-0.032501787,-0.08477093,0.005329338,0.05246652,-0.01299783,-0.022057435,0.0041855676,0.03233644,-0.08295339,-0.039227556,0.036765076,0.1121016,0.06093768,0.11719838,-0.007939273,-0.029442854,-0.038781032,0.013846792,0.05058566,0.02621787,-0.10941369,0.053991076,0.04367845,0.053748067,0.019388374,-0.0856009,0.0014931397,-0.043035097,-0.036734473,-0.008731521,-0.025958166,-0.10296634,-0.016972348,0.02095102,-0.10716344,0.06585311,0.039987598,-0.03955829,0.10343622,0.0055500763,0.03310339,0.10286838,-0.041135408,-0.012554921,-0.01127779,-0.12062758,-0.065744594,-0.11753303,0.023092013,-0.013475977,-0.007762616,-0.04824242,-0.0066286717,-0.09766992,-0.016567998,0.06241195,-0.0030565986,0.031550486,-0.014874144,0.013674438,-0.062199313,0.15140389,0.062014382,-1.9563727e-08,0.055518422,-0.062275704,0.073601976,-0.03270965,-0.03984325,0.008668554,0.043439697,0.07214859,0.08540924,-0.122734874,-0.09734978,0.080136456,0.024187975,0.028969547,0.016023168,0.0036983124,-0.05344367,-0.009945916,-0.046152204,0.0016075451,-0.08656616,-0.008867244,-0.027847085,-0.042184003,-0.021717357,-0.038799815,0.052632194,0.045934282,0.034955166,-0.06419594,0.07705154,0.041206818,0.02936432,0.016597541,0.038940936,0.072077595,-0.012042859,-0.042282786,-0.07502113,0.015109801,0.0052659307,-0.08922073,-0.0450332,0.027263042,0.04838809,-0.04250966,-0.031849314,0.036846954,0.018810986,0.041361786,0.034396958,0.02715435,0.02895809,0.0030874873,-0.01674904,0.013042417,0.021951282,0.0042497087,0.013826895,-0.08668813,-0.011497567,-0.00067550846,0.18800023,-0.034554116 +3.1.1.36,Limonoate is a triterpenoid.,384,1.0,0.04398548,-0.046997275,-0.061142206,-0.013688958,-0.056280382,0.012231049,-0.027589967,0.01745819,0.038513932,-0.048852384,0.061173882,-0.028427167,-0.038012825,-0.08100549,-0.024268914,-0.031130502,0.087183654,0.024306253,0.04043173,0.016876152,0.02045331,-0.008659004,-0.027774332,-0.006997288,-0.0017126928,0.058026038,-0.01188556,0.03770994,0.002629878,-0.04820789,-0.016119797,0.07672712,-0.040871963,-0.004350358,-0.01891121,-0.011748499,-0.025607333,-0.01396928,0.12897517,0.07368486,0.12644811,-0.033918418,0.056222,-0.060651004,0.024507007,0.049667608,-0.11689005,0.050227094,0.024625722,-0.04126602,0.012408167,-0.07934262,-0.014072306,0.0066088974,-0.044916358,-0.015927495,-0.00042940158,0.042801343,-0.027889287,0.07120941,0.025466189,0.017791767,0.0014959205,0.032625984,-0.04548001,0.022014124,-0.0051861173,-0.04744568,0.025395589,-0.033845734,0.022880392,-0.020261323,-0.07914332,-0.017502878,-0.060366057,0.000423438,0.05002821,-0.031695217,-0.033990607,-0.04016914,0.03085568,0.107700214,-0.011097923,0.045306947,-0.017814936,0.020891154,-0.020085867,-0.01123618,-0.03554537,0.08801089,0.05501215,0.023545291,-0.019237638,-0.017752558,-0.07283427,0.010860333,0.068822585,0.022685282,-0.071119435,-0.04764195,0.008893037,0.0465949,-0.07066237,-0.10545448,-0.06447958,0.061024826,-0.0024933822,-0.09847785,0.06621447,-0.022102676,-0.040722724,-0.024857534,0.035777435,-0.06913916,-0.07191465,0.000487685,0.042530306,-0.039135758,0.019094232,0.030385947,0.0027767906,-0.0689345,0.008301165,-0.01789318,-0.0015378839,-0.075063154,0.02359673,-1.9238985e-33,-0.015437492,0.021102633,0.06684974,0.060309157,0.021526258,0.036227904,-0.05624149,0.024251211,-0.066183135,-0.10848521,-0.10435175,-0.044032626,-0.08054378,0.009736215,-0.021682002,0.047988564,-0.019334294,0.059315316,0.039915517,-0.06627007,-0.04125477,-0.012159498,-0.058987107,-0.038277965,0.0035028772,0.07240681,-0.0068548103,-0.06603384,0.042989288,-0.012343353,-0.019786974,0.0027898862,0.07244382,0.04575037,-0.012114796,-0.03696796,-0.052482814,-0.03387074,-0.09891604,0.02418175,-0.021428425,0.024494696,0.0084214015,0.04116631,-0.02345305,-0.06366309,-0.035287872,0.030316455,0.12624502,-0.059008814,0.062492546,0.03271802,0.08978348,0.032021172,-0.055345163,0.04423751,-0.020974964,0.03588853,-0.050343636,0.0062829135,0.048624985,0.1270861,-0.022645073,-0.04623786,0.0056004827,0.09530916,-0.15497552,-0.028739939,0.0943707,0.062057927,0.011492357,-0.035059668,0.09822961,0.042448223,0.08902787,0.041834082,0.03667914,-0.024389422,0.049171817,-0.01207561,-0.06131709,-0.049366686,0.113023825,-0.011947762,-0.07832633,0.005542144,0.016846424,0.041791946,0.045361947,0.042170364,-0.022962691,-0.0030028713,-0.06186304,-0.037369415,-0.027512426,6.2903407e-34,0.004955109,-0.036265247,-0.039306715,0.017588455,0.01668141,0.07734173,-0.12842742,-0.062918276,-0.040945433,0.01385833,0.042206526,-0.059265498,0.054136142,-0.033894412,0.09377507,0.048023697,0.02796986,0.04060487,-0.06627235,-0.038178105,-0.052276015,0.029535241,-0.027129343,0.08452833,-0.03856894,-0.004281914,-0.018655568,-0.043258026,0.023175916,0.056467284,0.061594144,-0.08088974,-0.037886914,0.007229566,0.029596737,0.13012075,-0.010031259,-0.025064116,-0.022620212,0.074051246,-0.068124294,-0.05103378,0.013247642,0.07628611,0.050235905,-0.048242304,-0.046061125,-0.015127303,0.017957557,0.07680722,0.057747893,-0.0043791705,-0.06351807,0.077633314,0.06742307,0.022146432,-0.046285044,-0.017776351,-0.0031652993,-0.07135694,-0.015195717,-0.04879356,-0.07903661,-0.038534492,0.029933633,0.017406158,-0.02461755,0.052130032,0.040922925,-0.0057775383,0.090118386,0.14725259,0.0061458102,0.018685602,-0.017335884,-0.011837166,0.05369441,-0.11130928,-4.9442966e-05,-0.024945827,-0.042387567,-0.027181031,0.022742894,-0.011202967,-0.07048134,-0.045677014,0.060581286,0.045751803,-0.009192829,0.03332479,0.0051113623,0.008520575,-0.09120322,0.04905943,0.015983384,-1.5926332e-08,0.07497725,0.011851817,0.014587629,0.06219517,-0.03131926,-0.05183984,0.05355306,-0.025223652,-0.025591606,-0.012227061,0.017218739,-0.03258678,0.026403455,0.0024637838,0.10949685,-0.012304796,0.056684766,0.013408854,-0.034745272,0.07375004,-0.04570813,-0.0115982145,-0.04512653,-0.093170196,-0.012642203,-0.099324584,0.02261115,0.018516596,-0.0074789594,0.020123161,0.0347287,-0.016413352,-0.01840464,0.0029204336,-0.035588466,0.0650055,-0.015820555,0.022398178,-0.0014750236,0.010577366,-0.0017805918,-0.030905167,-0.100724794,0.057712927,0.015795328,-0.0023956343,0.028490877,-0.047616772,-0.026548408,0.019553076,-0.009409944,0.03412252,0.1055825,0.039384928,-0.011479795,-0.059777334,0.028893502,0.060281042,0.0021914223,-0.042885832,-0.07261253,0.045537,0.19010623,0.06023344 +3.1.1.40,"The enzyme will only hydrolyse those substrates based on the 2,4-dihydroxy-6-methylbenzoate structure that also have a free hydroxy group ortho to the depside linkage.",384,0.99999994,-0.04998686,-0.062433116,-0.033804595,-0.06689298,0.07716338,-0.03150736,-0.08013343,0.011298955,-0.046652235,-0.034344647,0.073472925,-0.012417527,-0.096621275,0.02391691,-0.07283507,0.10223385,-0.052241694,0.0483693,-0.009159876,0.024946623,0.061895177,-0.06522035,-0.026417036,0.0013639007,0.034215204,0.036554597,0.093957685,0.0661896,0.07426413,-0.094918005,0.026045706,-0.0122811515,-0.06881713,-0.024325397,0.045968454,0.11864528,0.014039511,-0.0561493,-0.045968737,0.008017419,0.072418556,0.012687195,-0.05228249,-0.037529606,0.0048018703,-0.06829218,0.0018168718,0.062349617,0.054469943,-0.018181127,0.013631691,-0.030943988,0.019307734,0.013902032,-0.09588086,0.029817149,-0.03896047,0.029491836,-0.11929644,0.042677253,-0.014322491,0.0077886353,-0.024054969,0.0574878,0.034403577,0.012483959,-0.009250878,0.028956907,-0.05522968,-0.022572847,-0.08026139,-0.10007549,0.08326071,-0.0005893049,0.013427729,0.0057700938,-0.05726318,-0.005892791,0.07027546,-0.06807631,-0.0086132735,-0.058664203,0.044906594,0.13410065,0.011681665,0.044325206,0.008093237,-0.011734889,0.038192634,0.012932238,0.0058059637,0.0073019965,-0.024831716,-0.049366377,0.00096690183,0.06435766,0.015193139,0.03961293,0.0015832639,-0.030980403,0.025586564,0.044324465,-0.05320954,-0.046687283,-0.002897315,0.025634453,0.02338693,0.09267031,0.02122578,-0.012834702,-0.055080697,0.064430065,0.12594235,0.05626453,-0.037082475,0.012742157,-0.016425254,-0.042247847,-0.010751965,-0.083054125,0.020911757,-0.013458462,0.09624893,0.049590003,-0.03854406,0.11039022,-0.044496838,1.8802124e-33,0.04769605,-0.011514906,0.02853683,-0.10384885,-0.025719067,0.02067094,-0.07895638,0.07441318,-0.1138992,-0.016096758,-0.090849936,-0.08793699,0.023340957,0.032382518,0.022941029,-0.06229306,0.05230936,0.046648726,0.05360465,0.018425453,0.013701924,0.054277327,-0.12330258,-0.017331114,0.0022209447,0.06279976,-0.019339446,-0.003984973,-0.01538087,-0.015437034,-0.06693841,-0.049143247,-0.09311825,0.015115078,0.020429213,0.04932044,-0.0522402,-0.0038603316,0.005274427,0.023074474,0.048700847,-0.01580492,0.039463464,-0.073827945,0.02262394,-0.015706617,-0.028557803,0.05158432,-0.014828311,0.029727012,0.06252929,-0.013664118,0.010338051,-0.046045076,-0.034728233,-0.005470228,-0.028820304,0.044759247,0.055225167,0.022421999,-0.042982373,0.05803744,-0.07184803,0.03467925,-0.015414446,-0.023228915,-0.01346627,-0.056891687,-0.0066032335,0.05247841,-0.10230344,0.04089848,0.08247634,0.04748228,-0.01020427,-0.067901105,0.0005308945,0.0038426851,0.077420905,0.038973626,0.020577082,-0.01659886,0.010191404,-0.03651956,-0.019285165,0.04031946,0.0061540846,0.0013486688,-0.024603453,0.026348716,0.092946954,-0.07721408,-0.056010034,-0.023909843,0.04019198,-3.7451335e-33,0.047103174,-0.054630294,0.016657451,-0.09943875,-0.013797071,0.038557116,0.08751932,0.012334849,0.09733513,-0.009043832,0.075908996,0.010797931,-0.010689569,-0.061269864,0.0076932106,0.072953135,-0.05638609,0.06449753,0.036466364,-0.034280285,0.03502564,0.11336003,0.006750987,0.06627251,0.06503453,-0.013414505,0.04470238,0.07310955,0.061477616,0.075727664,-0.04659021,0.04202491,-0.026253138,-0.03231932,0.0017182151,0.062666446,-0.15200159,0.027978893,-0.010244337,-0.0044324067,-0.03454555,0.009371883,-0.064734444,0.064948894,0.02417634,0.058150385,-0.077714354,-0.034903612,-0.004407619,0.025303215,0.0059675374,-0.019348342,-0.008474926,0.04350682,0.020881051,0.013748779,0.020289922,-0.035971478,-0.06295934,-0.041364998,-0.030460285,-0.008457947,-0.028574673,-0.005809235,0.014349856,0.068094745,-0.0012084264,0.03642998,-0.009994605,-0.017495217,0.050938316,-0.033816192,0.02402972,0.02203444,-0.007186346,0.020920804,-0.122058384,-0.036930665,-0.04751859,-0.07487396,-0.011389566,0.05326358,-0.03484262,-0.029308727,0.012772608,-0.04170215,0.021235054,0.059552114,-0.021788908,0.065629534,0.056778364,-0.019009467,-0.0610469,0.07926959,0.051695567,-3.457013e-08,0.025733555,-0.12782305,0.0936812,-0.068591736,-0.024607373,0.022454696,0.02774895,-0.0058626872,0.042702306,-0.025900496,-0.012782071,0.045055613,-0.05442989,0.057252206,0.028435525,0.012832414,-0.012630703,-0.016743155,-0.060511712,-0.045918167,-0.051672254,-0.0220944,-0.08835456,0.079483084,-0.0026345847,-0.02966353,0.0011204185,0.014679105,0.056009933,-0.0116790915,0.034513425,0.04557105,-0.05606693,-0.009246065,-0.018758047,0.07266128,-0.082252,-0.0072395634,-0.068167165,0.03559918,-0.013139826,-0.09690624,-0.004141595,0.00080083986,0.053610455,0.0065305326,-0.022752468,-0.026622528,0.043234833,0.06026362,0.038493004,-0.057037838,-0.008643915,-0.102993175,-0.058928125,0.005673448,0.0022802239,-0.049256153,-0.0024575943,-0.05632386,-0.00928385,0.013750549,0.2187218,-0.058098316 +3.1.1.41,Hydrolyses the acetyl ester bond on the 10-position of the antibiotic cephalosporin C.,384,1.0,-0.05731394,-0.036947265,-0.06763057,-0.05312607,0.026853347,0.04814057,-0.07041948,0.057802282,0.11074614,-0.03784963,0.066068105,-0.08057641,0.025493411,0.08278394,-0.08106214,-0.053818163,-0.057157736,0.012722271,-0.021023894,0.02016414,0.009959761,-0.012884652,-0.02744639,0.044888105,0.023793789,0.029495437,0.052557833,0.0008693465,-0.012715802,-0.09701977,0.098939165,-0.05193192,0.050992962,-0.048958316,0.03983398,0.019946018,-0.016947296,-0.058748253,0.17886099,-0.0072995145,0.012336982,-0.0057971952,0.0060928776,-0.0069835875,0.016690105,0.018194266,-0.030333268,0.014180442,0.09120715,0.032424904,0.01518832,-0.026304455,-0.0763457,0.06564685,-0.026604718,0.059428435,-0.049085233,-0.013868586,-0.028914612,0.023139674,0.07328923,0.027353533,0.031096462,0.07386334,-0.13089831,-0.05054765,0.03420953,-0.04415551,-0.007896295,0.02294456,-0.1165217,-0.06386801,0.079010166,0.102500185,0.0025982799,-0.037739176,0.028309321,-0.08343375,0.0005316462,-0.03160141,0.05689723,-0.016910173,-0.027524175,0.14472185,0.030439138,-0.04537693,0.05846907,-0.09244854,0.06448434,0.039971806,0.03162344,-0.00893697,-0.060310178,-0.04271489,-0.025074627,0.007091171,0.05435389,0.0030165627,-0.030696478,-0.027006587,-0.034910236,0.05615139,0.031428114,-0.08420089,0.05309227,-0.01138159,0.026891958,0.051797062,0.044847056,-0.040996756,0.018163646,-0.060053818,-0.01611962,-0.09146463,-0.07509208,0.032769755,-0.014077283,-0.02840876,-0.0016003809,-0.04942157,0.029461054,-0.040915422,-0.006025396,0.024804777,-0.02499368,-0.021613736,0.03423004,-1.0904216e-33,-0.019281482,-0.029274343,-0.018647736,0.024030365,0.027792245,-0.09515898,-0.03113888,0.041586857,-0.065466836,-0.055933747,0.0037395896,-0.073143035,-0.0099728545,0.082360506,-0.03046139,-0.011937808,0.032443672,-0.0030482726,-0.012168867,-0.04153372,0.02384065,0.07980771,-0.022725621,-0.023600524,0.09700563,0.012860038,-0.09460943,0.06266079,0.06718382,-0.005691974,-0.006805185,0.056319974,-0.06103266,0.028753245,0.06618807,0.07014504,-0.001962766,-0.043107778,0.08879955,0.067536004,0.042295527,0.041580185,0.017714802,-0.03951696,-0.0026182926,-0.00040338282,-0.030814642,0.021236105,0.06756487,-0.020649243,0.112892,-0.09898817,-0.014213898,0.08466955,0.004712916,0.034775194,-0.065383926,-0.0048404615,-0.009704989,-0.016513584,-0.02666564,0.044856273,-0.06743386,-0.030682383,0.0555652,-0.0054168585,0.0046630735,0.014444927,-0.0021674004,-0.042705376,-0.08755773,0.02637566,0.04437779,0.07577289,-0.020349953,0.022695018,-0.007156664,-0.0078366855,0.09713074,0.004261696,0.012609733,-0.0014513971,-0.012925706,0.03353644,-0.031852506,0.06748461,-0.018247427,0.03495461,0.04842047,0.036349628,0.021974007,-0.054296926,0.00069539464,0.02953826,-0.07692654,-2.0192107e-33,0.11152568,-0.08892428,0.02363041,-0.01580337,-0.07312965,0.0886041,-0.0008206063,-0.053448796,0.0023794963,0.040704384,0.100283116,-0.024749381,-0.06332247,-0.060042843,-0.036698133,0.020872628,0.004582146,0.044957727,-0.087744735,0.047595438,0.036918152,0.010460893,0.0017725605,0.0053302515,0.10326131,0.012682382,0.030556466,0.05230544,0.0049569956,0.06764632,-0.03676777,-0.08899494,-0.05302974,-0.07859539,-0.07734336,0.07648424,-0.07476552,-0.0023550475,-0.012846397,-0.044266343,0.010716949,-0.014947674,0.004346585,0.016929505,0.09145733,0.052300308,0.018298512,-0.040667057,-0.010869777,0.022330461,0.03772137,-0.025182864,-0.0102827065,0.0032981653,-0.062080756,0.047631484,-0.03197846,-0.004352225,0.093940996,-0.103789866,-0.010998654,-0.01296784,-0.01182433,-0.042514842,-0.027457235,0.061636254,-0.06212955,0.038895693,0.07331086,-0.13953906,0.029524604,-0.07485767,0.024842473,0.014753274,-0.023233581,-0.02359413,-0.03113662,-0.13125896,-0.005551248,-0.015707714,-0.017701749,0.03160356,-0.010680754,-0.08184791,-0.047037378,0.0570361,-0.029069299,0.0008245562,0.004244645,0.0005543916,0.0022383565,0.056145377,-0.018679168,0.0020066625,0.04760055,-2.456531e-08,0.035602737,0.0110267885,0.08873865,-0.03886535,-0.010139888,0.009451291,0.05870497,-0.084155306,0.03121285,-0.04603461,-0.03901984,0.12754394,-0.04181857,0.004558491,-0.056951493,0.015957406,-0.12015522,-0.04560971,0.0064747953,0.016584886,-0.073031925,0.0077517526,-0.044183597,0.02187051,0.04501373,-0.024044123,0.04006202,0.06865631,-0.098245494,0.036928844,-0.00032307906,0.05483305,-0.040732905,0.00021752369,0.049429182,0.0022087393,-0.034130134,-0.054785594,-0.019301556,0.055882152,0.0371824,-0.011072308,-0.027149573,0.022956848,0.037615057,0.051882345,0.0100232,0.046391558,-0.015262604,-0.053366497,0.06805603,-0.030726247,-0.060544495,0.022335742,-0.08258351,-0.0035372747,-0.028705133,-0.02253234,-0.038094874,-0.039775908,-0.07729854,-0.0578418,0.13335201,0.017675366 +3.1.1.42,"Also acts, more slowly, on isochlorogenate. No other substrates are known.",384,1.0,-0.033624377,-0.12015638,-0.040487472,0.034466416,0.08530856,0.029511295,0.0068677487,0.02637998,0.049723774,-0.021375062,0.0902441,-0.049264833,-0.075486764,0.09606087,-0.009619858,0.053728923,0.0065784515,0.043921698,-0.0075565004,-0.020947222,0.07818899,-0.056208346,-0.026836025,-0.038831342,-0.036770873,0.033796575,-0.005071619,-0.062459834,0.0653662,-0.08915194,-0.0336069,0.050286677,0.10321761,-0.043633055,0.015480377,0.062600404,-0.044923913,-0.041691694,0.008573701,-0.0017819582,0.034290656,-0.055119466,-0.039976254,-0.0018258971,-0.023382945,-0.020817855,0.056261327,-0.039797798,-0.026392097,-0.012048082,0.014523281,-0.0024407995,-0.07075039,0.027556242,-0.08456804,-0.020456266,-0.03142744,0.052223906,-0.012320577,-0.029695494,-0.061970197,0.015861377,-0.03319369,0.0029364834,0.029920956,0.039905023,0.06436965,-0.01664441,0.031164512,-0.063148506,0.0044838306,-0.007729463,-0.034128077,0.0018386231,0.03400161,-0.021688942,0.043501914,-0.02508457,0.0022862123,-0.03240997,-0.044826925,0.034166224,0.019765707,0.044690073,0.027233478,-0.006829775,-0.04989019,-0.046405226,-0.085392796,0.024661902,0.016314933,0.07521619,-0.06969091,-0.001991091,-0.036266025,0.061942752,-0.012336293,0.04085426,-0.008684951,-0.02069583,-0.034717225,0.032247685,-0.17533402,-0.02147208,-0.00050817436,-0.00031830638,0.007758074,0.019871963,-0.054818816,0.037914526,-0.010612607,0.017807312,0.053891264,0.015735582,-0.011508829,0.05116946,0.052069843,-0.023426175,-0.0427666,0.03792581,0.0150422035,0.010159125,-0.0024312977,0.06689967,-0.07074346,0.07121123,0.016071951,-6.2967963e-34,0.031062832,-0.0130904885,0.038702425,0.010468228,-0.07389853,0.0016884852,-0.051743906,-0.005824636,0.01216249,-0.09440036,0.0065188324,-0.06909136,-0.021644218,0.042138785,-0.0101359,-0.05027116,0.0019312756,0.04363643,0.05815896,-0.0312775,-0.03564421,0.097368784,-0.046332136,-0.038067445,0.035651773,-0.010055873,-0.025030207,-0.03586543,-0.0004868635,-0.018047119,0.035453353,0.014979422,-0.054983635,0.05031989,0.032607496,0.08334862,-0.05170478,0.015317401,-0.008283451,-0.005061278,-0.05714176,0.024805358,-0.06139326,-0.05740295,0.08247739,-0.037633464,-0.07876138,0.050036807,0.03572428,0.06331867,0.039653048,-0.020195875,0.020321714,-0.051180895,0.0012230828,0.069145076,0.014220318,-0.06589175,-0.042546105,0.06919542,-0.018408066,0.07929593,-0.05754184,0.06478504,0.044689626,0.036349285,-0.113619685,-0.072608784,-0.050950594,-0.019443039,-0.07831242,-0.02840229,0.06796285,0.045107428,0.034870327,-0.06343904,-0.05038184,-0.052616354,0.028682545,-0.013714988,0.008105369,-0.054430258,0.020771528,-0.08151926,-0.13708712,0.010429959,0.008117797,-0.028734032,0.02112425,0.02932536,0.078112446,-0.044365365,-0.09841935,0.0013312178,0.0003539465,-1.942904e-33,0.06662761,-0.12925139,0.00011928323,-0.0012384423,-0.032237798,0.042150278,-0.045184307,-0.009213885,0.007846537,0.0625567,0.070947215,0.015320934,-0.098318994,0.029599238,-0.031779174,0.038010165,0.061567847,0.14800367,0.01575462,-0.0048804875,-0.016618155,0.093350746,0.049939055,0.11941115,0.04425974,-0.028524414,-0.020192398,0.053452156,0.031163331,0.024929075,-0.0553517,0.020484135,-0.040889565,-0.04715999,0.032458857,0.026549378,0.010052399,-0.02062333,-0.08597093,-0.064726,-0.044797767,-0.011436403,0.03611587,0.006796468,0.021685941,0.044770483,-0.03862595,-0.046072684,-0.070699066,-0.005121478,0.0069059525,0.015325209,-0.07184741,0.0098656835,0.05177694,0.06536485,-0.003943151,-0.03552238,0.030053612,-0.018637843,0.04688389,0.023331545,-0.042465426,-0.087802984,0.11978786,0.027785784,0.011222922,0.09307023,0.082578376,-0.013920259,0.13070378,0.032339234,0.0051884116,-0.036589902,-0.06995126,-0.057580143,0.024376543,-0.07268083,-0.0794919,-0.063019946,-0.046933472,0.024084957,0.019470049,-0.08676389,-0.089528516,-0.051546674,-0.04235337,0.0044252244,-0.006708249,0.057529014,-0.05791632,-0.011640671,-0.011457725,0.059706885,0.04957789,-2.4500384e-08,0.004553787,0.014182541,0.10049631,-0.021579616,-0.060682666,0.050754357,0.07927087,0.045108344,-0.0009551853,-0.04759032,-0.054612763,0.10533012,0.12656558,0.004211796,0.1145925,0.028249241,-0.0054863673,-0.056775983,-0.028458584,0.00083400233,-0.0801367,0.01117497,-0.060583457,-0.0047378778,-0.050186668,-0.08018927,0.11772947,0.120020434,0.057677936,-0.06611577,0.06438765,-0.016568499,0.0041860715,-0.020280734,0.040117934,0.056580592,0.023354473,-0.07827453,-0.033506367,0.06467206,-0.056047007,-0.003487675,-0.046227675,0.028383216,0.07651026,-0.008441459,0.011606124,-0.016395362,0.029308006,-0.0020484554,0.06125458,-0.006408619,-0.06350964,-0.037852384,-0.06309028,0.025242086,0.023583684,-0.0155719435,0.06322493,-0.028328525,0.05097097,-0.038290784,0.12750241,0.025254501 +3.1.1.43,Also catalyses alpha-aminoacyl transfer to a number of amine nucleophiles.,384,0.99999994,0.007987577,-0.07949911,-0.053696018,-0.0075631086,0.053275045,0.060082197,0.026555898,0.009191214,0.028903257,0.047875334,-0.0120030865,-0.03174829,-0.02153222,0.08625406,-0.037271354,0.06975101,-0.085421845,0.06507927,-0.052233357,-0.06072316,-0.009352613,-0.006486127,-0.029347224,0.030332515,-0.0026979626,0.0786403,0.012200415,-0.08856206,-0.008649859,-0.076377966,-0.010128999,-0.031112252,0.06228784,-0.010469453,0.0071825925,0.08846474,-0.07976056,-0.011622277,-0.028543198,-0.025730284,0.018872889,-0.0036307098,0.068402715,-0.04992026,-0.08729241,0.01531561,0.020188546,0.048600256,0.06595304,0.031480137,0.010148703,-0.057372842,-0.07351654,-0.008493862,0.009369636,0.099807635,-0.02052414,-0.08130623,-0.028495736,0.09314758,-0.04958737,0.005763394,-0.036182337,0.013662109,0.012573005,-0.00935045,0.04017896,0.001168364,-0.04063906,-0.0036189144,-0.0074687144,-0.068985805,-0.06831725,0.02241384,0.006512096,-0.056298975,0.043910053,-0.060397673,0.046772968,0.0058573955,0.00753558,0.011040252,-0.00015845988,0.081347965,0.07386851,0.10819557,-0.03201689,-0.013550304,0.05593795,0.016966918,-0.025010666,0.020252809,0.049887653,-0.06180007,-0.006138913,0.00792465,-0.03539711,0.051906776,0.021123186,0.011089418,0.0144354105,0.066555694,-0.098286405,-0.05883867,-0.06329393,-0.013306655,0.052753575,0.02967912,-0.029285984,0.047416426,-0.0019764062,-0.004863457,0.0685597,-0.0015050848,-0.037379432,0.047891393,0.053077955,0.02431007,-0.056994975,-0.009321548,-0.012013411,0.015187878,0.050682023,0.078408055,-0.07943872,-0.0038974162,-0.014269466,6.70112e-34,0.018578643,0.05081719,-0.020079225,0.07918515,-0.017734932,0.02410822,-0.015594331,0.0125473365,0.07326465,-0.06523906,-0.071677044,-0.057888333,0.05769444,0.011856674,0.02151352,-0.08470431,0.012821662,0.06874769,0.013739897,0.007968276,-0.02677019,0.08522094,0.031792156,0.028216636,0.0512521,-0.0036094699,-0.04465227,-0.0023826836,0.07490929,-0.022622898,-0.024148427,0.06259133,-0.14984067,0.005473172,-0.02481571,0.035615295,-0.07028916,-0.05872267,0.051890884,0.12916066,-0.029404722,0.0008140387,-0.0818749,-0.014208573,0.013251327,-0.004446207,-0.016685277,0.064444214,-0.029248599,-0.009398574,0.006888805,-0.041177653,-0.012647636,-0.048656967,-0.028665718,-0.03273293,-0.013142514,-0.02974713,0.020475501,0.08483602,-0.03822538,0.04512512,6.437527e-05,-0.027523614,-0.0011547008,0.011493468,-0.03375208,-0.07833942,0.034272525,0.037180703,-0.017818756,0.028342249,0.06195833,0.039257444,0.01733225,-0.04214012,-0.09682969,-0.034732807,0.059413858,0.029996118,0.022984073,-0.015038596,0.013031615,0.00011082441,0.0041296124,-0.003289798,0.054371838,-0.057341263,-0.05580061,-0.017498417,0.06021165,-0.12110475,-0.066678494,-0.017615939,0.0020200675,-2.5068497e-33,0.08705433,-0.15249509,-0.05868286,-0.019465117,-0.09613537,-0.023045115,0.017681666,-0.095166124,-0.018609477,-8.451155e-06,0.0276208,0.03164963,-0.00016093005,-0.017629225,0.0092497,-0.09194814,0.048388574,0.026508348,-0.0022380603,-0.08610114,0.01299819,0.028268982,-0.016034378,0.00566302,0.0341245,-0.0038655815,-0.08167135,0.054224435,0.11790676,0.060094304,-0.058148764,-0.04037334,-0.014242699,-0.036773168,0.03446468,0.14744808,0.061218552,0.036786247,-0.009842623,-0.027168863,-0.031406872,0.037925664,0.07490215,0.05689694,0.021416703,0.064113416,-0.061141983,-0.0070886496,-0.043828834,-0.025599409,0.06716949,-0.020103278,-0.04448516,-0.038423292,-0.023643037,0.022442691,0.010971196,-0.09699281,0.039780963,-0.055601966,-0.07055039,-0.03339833,-0.021952463,-0.04138472,-0.05484677,0.051612746,-0.018506652,0.009508879,0.010772609,-0.00295578,0.050495006,-0.014905546,0.116978854,0.047787275,-0.02279216,-0.068595335,0.032618213,-0.0145470835,0.05267756,-0.06580685,-0.07194479,-0.011637436,0.02413408,-0.013558959,0.0037849217,-0.099967614,0.11492586,0.037728682,-0.0152384145,0.021485133,-0.029082105,0.004016208,0.07360018,0.0394001,0.07867785,-2.3282754e-08,0.07554029,-0.07884299,0.022858206,-0.038169008,0.051541038,0.104841344,-0.039541963,-0.026246145,0.042664453,-0.07249432,-0.073792,0.13296656,0.05149587,0.10848885,0.029692722,0.05843912,-0.0077081355,-0.055306304,-0.008600117,-0.06200276,-0.09490516,0.04657061,-0.10641586,-0.026984375,-0.041861996,-0.06237437,0.013223749,0.050326616,-0.03584186,-0.039211985,-0.010327974,-0.004539123,0.024784999,-0.058764145,0.055339035,0.05318003,0.055520874,-0.074226394,0.0087446105,-0.06784886,-0.0132616,-0.016696574,-0.027206272,0.039253037,0.04504377,-0.0110366,-0.016670357,-0.015754102,-0.056973774,0.036769193,0.09265423,0.008659263,0.02819302,-0.015599011,-0.07496015,-0.06772775,-0.052517626,-0.09198271,0.07238587,-0.011794622,-0.0040848227,-0.0037422865,0.15937153,-0.027042773 +3.1.1.46,"The enzyme opens the A-ring-lactone of the triterpenoid deoxylimonic acid, leaving the D-ring-lactone intact.",384,1.0,-0.057262205,-0.0887046,-0.010660511,-0.018720955,-0.033537254,0.012111393,-0.07922646,0.06290968,0.04591861,-0.0075829728,0.09019881,-0.0066688173,-0.07744857,-0.05567679,0.04627122,0.061776243,-0.043633986,0.056497563,0.010652194,0.00018902034,0.057526782,0.05555816,-0.0011196241,-0.036199443,0.07404083,0.065396614,0.08429824,0.050357033,-0.0075875637,-0.07678307,-0.00028003697,-0.02516978,0.002762519,0.012854785,-0.011907751,0.043773808,-0.024805717,0.010962164,0.11321165,0.012375362,0.090465784,0.042541027,0.055733725,-0.0066308226,-0.03874658,-0.0059792963,-0.112290956,0.048921186,0.012650457,0.010823021,0.025630875,-0.028387079,0.026949707,0.017279077,-0.043754146,0.07772338,0.08401507,-0.060620353,-0.037451353,0.04943982,0.044511728,0.0141596105,0.020819495,0.06218589,0.0020417573,-0.0505721,0.049113255,-0.033577427,0.023710584,-0.056708723,-0.031795762,-0.08106386,-0.05645673,-0.08017023,-0.025861144,0.049885303,-0.032178346,-0.07565526,-0.0034607202,0.007305013,0.0909789,-0.0316797,0.051766418,0.13020429,0.04567266,0.023760121,0.0823643,-0.053168494,0.011920741,0.058639523,-0.030119201,0.0011103543,-0.10769268,0.037404176,-0.10342886,0.00096790213,0.063645385,0.08210122,-0.12980023,-0.008626404,0.015098469,0.0073916093,-0.077714466,-0.088701434,-0.057630338,0.024604553,-0.0060696756,-0.08366327,0.037053518,-0.05329502,0.016909307,-0.009117127,0.043616727,0.040244397,-0.067849725,0.12503718,0.034959532,-0.021892974,0.065397255,-0.0138235735,-0.0029494215,-0.020339938,0.005203843,0.0113971215,-0.06812689,-3.5339417e-06,-0.0119269565,-2.2418938e-33,0.017239323,0.045244083,0.002068241,-0.032281563,-0.06027173,-0.044861607,-0.12436742,0.0071447156,-0.09578343,-0.02017687,-0.03541188,-0.019367091,0.0089839315,0.008196622,-0.030242918,0.0004043503,0.038931996,0.0001472364,5.8269407e-06,-0.074671805,-0.007574126,0.048547756,-0.062155038,0.0694385,0.04785299,0.06757176,0.011186307,0.02824783,0.061062813,0.028577251,-0.06823987,-0.07289429,-0.02369252,0.112426795,0.022243425,0.05279317,-0.007866466,0.028608538,-0.028413909,0.013735341,-0.026834173,-0.019620426,-0.039228123,-0.00768133,-0.029395703,-0.041996166,-0.011823662,0.05854051,0.019351836,0.035142776,0.015121866,-0.04327996,0.036112808,0.045650274,-0.07157959,-0.018828223,-0.0451631,-0.00026671748,0.038062237,-0.018810377,0.028102797,0.011441606,-0.025844082,0.043812312,0.044721697,0.072518356,-0.09089382,-0.13344996,0.016997816,-0.0046635196,-0.06809648,-0.019258695,0.05259111,0.013524056,-0.012114804,0.040578213,-0.038865436,-0.023060326,0.06269719,0.01790893,0.020212773,-0.047842328,-0.049881823,-0.05977571,-0.016343115,0.0148050925,-0.015791716,-0.02262186,0.025848743,-0.013252439,0.0324819,-0.0003123303,-0.032361016,-0.0046912474,0.052424103,-1.7557008e-35,0.028404256,-0.048052132,0.018836467,-0.029496163,-0.026509656,0.06548382,0.013361431,0.030754885,0.05074638,-0.013709379,0.060653657,-0.056929488,-0.041000742,-0.012575104,0.026311742,0.0076786117,0.0049030427,0.08208327,0.0052474574,0.0063180267,0.10286884,0.08683997,-0.02593015,0.107591115,-0.010059484,0.012386067,-0.019867903,-0.05428304,0.016065259,0.044642303,0.029663138,-0.024017468,0.027478486,0.026537454,-0.019217798,0.13453004,-0.056033894,-0.006585708,-0.045876425,0.09326127,-0.10880519,-0.0060286107,-0.03242042,0.06948205,0.09749262,-0.016618472,-0.049830552,-0.0007736854,0.0032846858,-0.05342234,0.08373105,0.006887826,0.046421282,-0.032523226,0.0038034478,0.10850676,0.03774134,-0.017167099,-0.02870075,-0.0117963,-0.025994904,-0.04428452,-0.028601019,-0.07880516,-0.050240025,0.004347213,-0.006075544,0.027864847,0.035771664,-0.045270793,0.041252095,0.15826538,-0.03929546,0.028173422,-0.011833105,-0.036753673,-0.09068028,-0.1328858,-0.047771223,-0.031857222,-0.05643135,0.031642936,0.032674912,0.010445305,0.0112235285,-0.09425522,-0.021385193,0.015087299,-0.028611414,0.020241328,-0.045969956,0.016102092,-0.06932575,0.079577744,0.064205274,-2.5552447e-08,0.06346621,-0.023396315,0.043502618,-0.026304087,0.052974325,0.011158948,0.060324464,-0.044398323,0.09025084,-0.08000783,-0.035209257,0.16762726,-0.05478394,0.059755925,-0.004434593,0.036031123,0.017647117,-0.018194085,-0.031290937,-0.01320115,0.035569634,-0.02456036,-0.051069308,-0.07317422,-0.033634994,-0.06619268,0.031950086,0.056959976,-0.042929973,0.014430802,0.05954958,0.007639213,-0.037504565,-0.022723492,-0.06413909,0.05602626,-0.031870037,-0.017178275,0.0019529371,0.025603771,0.013937355,-0.04722797,-0.075559914,0.04817237,-0.051463075,-0.01327015,0.030296557,-0.013689933,-0.023541065,0.05615012,0.006517595,-0.005677696,-0.0655584,0.003859704,-0.057033986,-0.0028435504,-0.0017208944,0.025144607,-0.084839866,-0.09625523,-0.039336853,0.022041352,0.15576428,-0.04996626 +3.1.1.48,Hydrolyses the three ornithine ester bonds in fusarinine C. Also acts on N5-dinitrophenyl-L-ornithine methyl ester.,384,1.0,-0.03803323,0.010027169,-0.03402381,-0.02602938,0.06432307,-0.023972433,-0.070687726,-0.027118646,0.08020048,-0.076056756,0.06153842,-0.044016153,-0.025104439,0.038638417,-0.06871599,0.04441756,-0.080055766,0.081676535,-0.061186977,-0.0039259032,0.03396802,0.018294832,0.058609895,-0.0041171275,0.03326395,0.0010557597,0.050113596,0.09098642,0.025672674,-0.10330272,0.024592325,-0.009684183,-0.05510212,-0.011284914,-0.018159974,0.029596934,-0.07184377,-0.019650182,0.074481286,-0.039215874,0.009929203,-0.10039921,-0.095042974,-0.037734024,0.003782958,-0.055356722,-0.06494658,0.034226038,0.069104865,0.0014982511,-0.0073328037,-0.008762728,0.029952599,0.017278448,-0.01852707,0.016512807,0.016494017,-0.040082388,-0.06265923,0.12640527,0.019749327,0.03900209,-0.061389025,-0.0038492135,-0.022912083,0.02168779,0.0125747705,0.00072433706,-0.014001618,0.02987759,-0.0062098983,-0.020836327,0.023648089,-0.06193686,0.06942153,0.039114133,-0.015222834,0.034323584,-0.006159172,-0.05823573,0.037931867,0.028416751,0.061073616,0.117914505,0.04007795,-0.043082625,-0.10478099,0.04178993,0.044062816,0.065931685,-0.016683811,0.025251236,-0.02751692,0.0031457632,-0.021000177,0.05482288,0.017711783,0.023014106,0.013033933,9.490806e-05,-0.016364722,-0.0054299426,-0.10741429,-0.0740454,-0.013015171,0.0072133695,0.031068575,0.020296361,0.032103315,-0.06417827,-0.07073457,-0.029082537,0.04267099,-0.08978549,-0.15019244,-0.019195447,-0.02377824,0.0026987917,0.0016562297,-0.05842202,-0.015043378,0.018950803,-0.04405618,0.05460383,-0.041133657,-0.020870727,-0.0709217,4.0310592e-33,0.02445328,0.08402995,0.008296134,0.061767783,-0.020730967,-0.015526609,-0.038387403,-0.013997985,-0.059804816,-0.084208414,-0.044213388,-0.06740825,-0.055682536,-0.01679313,0.01949225,-0.08362879,0.030586705,0.001442726,-0.035013046,-0.05751352,0.018717283,0.035503674,-0.1152566,-0.047098067,0.015381682,0.031907983,0.005197124,0.059059314,0.030494193,-0.037366655,0.0031429704,-0.014996695,-0.08788836,-0.048406433,0.10657283,0.05999987,-0.001657209,0.004455624,-0.030220496,0.034035183,-0.009297722,0.08566753,-0.047303885,-0.018812075,-0.018186387,0.08778324,-0.055656448,0.13048612,0.085702606,0.030198239,0.082712345,-0.04070539,0.031812254,0.045127355,-0.04865566,0.032676864,-0.011775017,-0.064073265,-0.015131737,0.013045582,-0.048221536,-0.040458303,-0.0063187564,-0.0151947625,-0.02095466,0.03244014,-0.07255806,-0.02074812,0.06269842,0.04324446,-0.0832704,0.0725847,0.060969613,0.016984493,-0.005722523,0.04516351,-0.091779634,-0.059348423,0.017755544,0.0157314,0.050195623,-0.09163985,0.04298512,-0.038255926,-0.06324876,0.030462855,-0.039942008,-0.061180267,0.058244795,0.03688761,0.05199143,-0.096325226,0.039992176,-0.041019123,0.015030735,-5.6818284e-33,0.03638026,-0.05602708,0.024434568,0.00371827,-0.052531987,0.025526186,-0.0746503,-0.004225826,-0.01112289,0.018572932,0.04303687,0.010722979,0.07475809,-0.07076687,-0.036157534,0.10401406,0.05446913,0.11669011,0.03311388,0.040564425,-0.053368177,0.022840284,-0.010010978,0.09912296,0.0034276545,0.08179275,0.04825933,-0.005295032,0.065339945,0.11119772,0.004289873,-0.0121095395,-0.024383733,-0.021503313,0.11092365,0.029801268,0.05840912,-0.041366372,-0.0155452,-0.024234066,-0.009196138,0.09322774,0.060574632,0.03261036,-0.015991328,0.052077606,-0.07742809,-0.0155210495,-0.053991687,-0.019008644,0.013961515,-0.035474047,-0.055427395,0.01409215,0.0014516524,0.0070194714,0.079698354,-0.11157085,0.01137253,-0.062404696,-0.027105168,-0.03165566,-0.04758936,-0.018276291,-0.038179796,0.048263084,-0.019828131,0.074452534,0.058973107,-0.04645619,-0.042545456,-0.024354475,0.033077557,0.021309163,-0.057118084,0.015247561,-0.0022317953,-0.076180145,-0.037669566,0.049707048,0.023399794,-0.0022163903,-0.05476693,-0.10637227,-0.079499125,-0.03445622,0.038943972,0.10883975,-0.06321902,0.015447613,0.05679233,0.039262895,-0.008867185,0.10613392,0.03342563,-3.259976e-08,0.049833324,-0.07337948,0.049719848,-0.046821956,-0.0505952,-0.016434489,0.029645026,-0.030755784,0.057913583,-0.03450814,-0.05035582,0.09098038,-0.03966276,0.0016338964,0.018297022,-0.0009796619,0.016861103,0.031394932,-0.013054532,-0.01259881,-0.09631721,0.05929373,-0.048026193,-0.0012685506,0.040038146,-0.033379473,0.016038436,0.03871519,0.12042425,0.015714096,-0.008258784,0.053137623,-0.052790783,-0.040022068,-0.034914505,0.08834268,-0.028000936,-0.047081433,0.010396564,0.072993,0.04128227,-0.030014671,-0.038145818,0.01886794,0.011935791,-0.023686608,-0.0021489793,0.02649665,-0.023168176,-0.011756343,0.049342602,0.008275021,0.014071331,0.008836516,-0.10763743,0.006421407,-0.027509313,0.074214555,0.024209231,-0.1262955,-0.05049962,-0.020875346,0.14828862,0.015310525 +3.1.1.50,"Also acts on long-chain acylglycerol, but not diacyl- or triacylglycerols.",384,1.0,-0.02709832,-0.06782618,-0.010921636,-0.005800043,-0.022714484,-0.049254917,-0.0272443,-0.004465219,0.06297987,-0.078561135,0.06419197,0.042040043,-0.037700467,0.041426916,0.05197864,0.056135792,-0.026099702,0.02016253,-0.020910505,-0.085094556,0.055795487,0.035395626,0.0018108273,0.036622506,-0.10937396,-0.044351403,0.05956448,0.016162403,-0.024585703,-0.10935869,-0.002475135,-0.02111862,-0.030701108,-0.031951576,0.020770172,0.024382155,-0.02721519,0.059552375,0.011159663,0.05997667,0.10973539,-0.076851994,-0.032696765,0.032490116,0.018985411,-0.01221489,-0.070745185,0.02234193,5.7952057e-05,0.09616629,-0.07135472,-0.0098766675,0.0024368856,0.057365093,0.0066019124,0.03898375,-0.14737722,0.014637033,0.021649756,0.010621896,-0.010927701,-0.008987459,-0.02188816,0.040889483,-0.10426584,-0.011146698,0.019241989,-0.04858202,0.08367274,0.004082048,-0.022664532,-0.12097807,0.0051893974,0.06640045,0.028344672,-0.02449045,-0.030673888,-0.08285179,0.041338123,-0.04372109,-0.015870787,0.020050831,0.06058558,0.05582393,0.05327032,0.034457672,-0.0019715133,-0.08758447,-0.07038044,0.01448636,0.04341185,-0.1127021,0.033655062,0.013900976,-0.054065112,-0.07151194,-0.0058313487,-0.017908435,-0.05247472,-0.02865117,1.618083e-05,-0.013590065,-0.0025123344,-0.019933589,-0.045224454,0.020481851,-0.007423014,-0.009199686,0.027748728,0.01436641,-0.01902194,0.022233455,0.10026733,-0.027580978,-0.08445116,0.03349923,-0.009227302,0.051213533,-0.0163934,-0.0049356874,-0.0030997714,-0.051434822,0.00479719,0.014838968,-0.04025239,0.087902755,0.012853288,1.2742974e-33,0.0066826637,0.0041537206,-0.0024120342,-0.0045657167,-0.0007144792,-0.011434185,-0.040389404,0.019384475,-0.034745846,-0.019894414,0.035601333,-0.0464071,0.003532899,0.10272579,-0.034586996,0.00024079862,0.00532058,0.039455872,0.049458265,-0.06644097,-0.010374458,0.08960894,-0.019755026,-0.025758784,-0.010619751,0.030278292,0.012421401,0.058532078,0.026693191,0.0026647034,0.026136458,-0.021611275,0.04646854,0.056451604,0.01866013,0.10524127,-0.01603368,-0.024122525,-0.014937577,0.030979803,-0.061262827,-0.013434909,-0.033375673,-0.029635236,-0.01721895,-0.056604747,-0.112611614,0.13557772,0.008258954,-0.0005683963,0.063072175,-0.012106981,0.07972686,0.06215934,-0.0072737713,0.0067383233,-0.04573015,-0.0010407063,0.018035334,-0.0052726264,0.027028296,0.09181769,-0.049631167,-0.003483476,-0.012992864,0.03594754,-0.094556965,-0.026252754,-0.045101043,-0.014695646,0.04113014,0.05766225,0.10627463,0.062505186,0.046898156,-0.033305608,-0.07740867,-0.01076917,0.023952154,0.03814785,0.012611705,-0.096385844,0.12627432,0.027190028,-0.017988002,-0.022699125,-0.067190275,-0.062850125,-0.0076244045,0.009904247,-0.017961914,-0.004179315,-0.023996675,0.08142663,0.062158868,-2.9275874e-33,0.008640353,-0.032815125,0.07700641,0.011002233,0.028430123,-0.0074367826,0.012694749,0.004923116,0.03870764,-0.03146134,0.08988263,-0.02926665,-0.08455546,-0.0084915,0.041108575,0.0684352,-0.018384153,0.01496188,-0.06654621,0.0029406936,-0.037888095,0.0052919895,-0.05458614,0.14170223,0.021290421,0.055654693,-0.030811097,-0.044611827,-0.006201399,0.08860772,0.039086122,-0.004969149,-0.06484638,-0.11336371,-0.053733557,0.0192756,-0.087801084,0.0056371884,-0.066623755,-0.08272767,-0.008807916,-0.05480491,0.048848234,-0.01306564,0.049182687,0.0025803496,0.02802709,-0.024979534,-0.0037744832,-0.04074296,-0.04266257,0.049482804,0.0028329315,0.06368502,0.04711886,0.11413824,0.0020395215,-0.039671425,0.011462284,-0.07327103,-0.08696733,-0.04021522,0.020525046,-0.026686447,0.09014511,0.05105649,0.026060207,-0.00046105302,0.08663115,-0.0065206736,0.06162585,0.07615185,-0.030711325,0.007529818,-0.11071612,-0.012936194,-0.0050460794,-0.11521098,-0.052100748,-0.004563376,-0.0023785823,-0.0476378,0.0069471747,-0.056307334,-0.08078073,-0.0022541962,-0.03273797,0.019121325,-0.042837646,0.09817039,0.0418771,-0.010476397,-0.060151923,-0.016021429,0.033870272,-2.4660421e-08,0.09168887,-0.043401036,0.03409439,-0.077157125,-0.08635311,0.0094628,0.09877894,0.068954445,0.0040658507,-0.07159883,-0.041890327,0.15507664,0.04698553,0.007886074,0.05851094,-0.0317501,0.035323456,0.0720163,-0.0051293587,-0.08190127,-0.085448794,-0.018674009,0.0012951839,0.061566025,-0.0780648,-0.08889947,0.048353758,0.05499083,0.019214856,-0.001534653,0.019086007,0.019920997,-0.04134301,-0.003798643,0.053192105,0.04648386,0.012983858,-0.008709877,-0.04674705,0.096216954,-0.030570105,0.012514118,-0.024872163,0.060005877,0.033300277,-0.08673158,-0.011729064,-0.015778607,-0.028967159,0.029003214,0.02614981,0.04698542,-0.0023076576,-0.0684046,-0.07552792,0.0066753807,-0.039950985,-0.045642693,-0.022663021,-0.0052359495,-0.024724798,-0.053557087,0.18351999,0.0102868695 +3.1.1.51,"Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil.",384,1.0,-0.069625095,-0.015010494,-0.043713845,-0.084770195,-0.024544165,0.023467643,0.022230554,0.01883784,0.06627956,-0.045777407,0.069982626,0.006987309,-0.08157657,-0.059832487,-0.08299431,0.03161175,-0.027070612,-0.035495844,0.01580106,0.07372764,0.040365998,-0.010091643,-0.011285196,0.08026359,0.06781012,0.05518833,0.0513746,0.05789635,-0.008806596,-0.025552057,0.06491556,-0.051677305,-0.0385829,-0.049250036,0.037607934,0.04227212,-0.042936288,-0.04211987,0.038892183,0.1063183,-0.0069843964,-0.049766682,-0.0052304505,-0.021907892,0.015376414,-0.119731985,-0.08351398,0.014781226,0.059876,0.017801754,0.014822481,-0.0020074593,-0.07607617,0.10213221,0.029781036,-0.007875567,-0.10874276,0.05756005,-0.011111672,0.082469895,-0.0044907047,0.014007099,0.013987032,0.045811687,-0.1094417,-0.07372659,-0.022009192,0.0063000876,-0.020501697,0.055770174,0.007839491,-0.039030846,-0.023084303,-0.074375816,-0.040559314,-0.016091513,-0.027608916,-0.018358583,0.008405202,-0.008665378,0.034836132,3.6655034e-05,0.030919967,0.08973303,0.09202741,-0.001264204,0.0033673288,-0.049238857,0.06667649,0.05672332,0.01737229,-0.010497385,-0.0028103392,0.030744359,-0.13171992,-0.009873816,0.049564973,-0.032780707,-0.013017542,0.06061575,0.019612836,0.05441637,-0.06513583,-0.11683198,-0.10005752,0.098522566,-0.031759784,0.04254732,-0.017061869,-0.013421515,-0.025134455,-0.022685101,0.010620754,-0.042288136,-0.03586419,0.04184024,-0.10062192,-0.07770048,0.051306047,-0.04567312,-0.023328327,-0.052407164,-0.0018831647,0.034530833,-0.01791931,0.011415025,0.00514258,1.8884126e-33,0.10010845,0.021010363,-0.0017706429,0.02571325,-0.08906892,0.05852818,-0.06149243,0.03811181,-0.08214814,-0.13229859,-0.028944751,-0.04638957,-0.043509718,0.028504224,0.0014394904,-0.057681087,0.04813385,0.03494907,0.10669536,-0.07012638,-0.042769082,0.044621672,-0.07943712,-0.05375711,-0.082651824,0.06747738,-0.08882723,0.117051,0.032057155,0.04631231,0.050239235,0.0013259143,0.028910233,0.04691869,-0.030471561,0.00973122,-0.04108872,-0.030385887,0.038919605,-0.0037308238,0.06223868,0.008843207,-0.027015056,-0.022797493,0.04889177,0.008855272,0.034523685,0.019717839,0.043084696,-0.048471387,-0.03243642,0.015747175,0.106849514,0.068923466,-0.018975142,0.024355879,-0.07336618,-0.006411771,0.01230101,0.049560808,-0.034314778,0.05447262,0.028588045,0.033247534,-0.05570194,0.011529342,0.015463308,-0.054109212,-0.047780506,0.039838187,-0.06427335,0.10060377,0.095032826,-0.005276131,0.06818301,-0.0030022333,0.04462988,0.041317888,-0.068159275,0.092200264,0.012288716,-0.06322825,-0.012429078,0.032521375,-0.049381033,0.005217581,-0.020260422,-0.036730733,0.0007668397,0.12031088,-0.021336928,-0.13832904,-0.030886672,0.04834443,0.00063824566,-3.1491192e-33,0.029274259,-0.04018502,0.062744185,-0.07230487,-0.0850305,0.07974593,0.041751765,-0.020911261,-0.038677115,0.0066281315,-0.009752301,0.031048236,-0.0033566046,-0.09507543,-0.0065927706,0.011060968,0.01916972,0.10659613,-0.04464742,-0.04747373,0.027755586,0.049325246,-0.06671376,0.05074332,-0.010449208,0.05416467,0.029154016,-0.019375702,0.00498097,0.069297194,0.049623743,-0.055494014,-0.016912859,0.022383898,-0.0842734,0.12484458,-0.050010957,-0.03779856,-0.031020598,0.054910503,0.0747392,-0.026347933,0.014323491,0.01572705,0.041378576,0.028693737,-0.026933828,0.02506529,0.027149772,0.02344138,-0.025198877,0.030178152,0.00630824,0.034209073,0.078726985,-0.0012395614,-0.06470069,-0.049344253,-0.03758564,-0.0037988622,0.010975729,-0.032020252,-0.06647034,-0.02420207,-0.011823395,0.06391273,-0.036294173,0.018197061,0.02845987,0.070236854,-0.00089573796,0.03118871,-0.010419066,0.032017834,0.01191746,-0.030419657,-0.037636705,-0.15424766,-0.07381114,0.0073678913,-0.021700462,-0.07221265,0.037491307,-0.11783306,-0.043477144,-0.020432645,0.00264169,0.0009544927,-0.024996884,0.06590391,0.0593726,-0.011411109,0.0066975183,0.06175083,0.037527613,-3.2534142e-08,0.04087285,-0.0873926,0.11678585,-0.066775516,0.003097962,0.008563109,0.034398828,-0.010404213,0.0090509765,-0.050641146,-0.029526634,0.050138205,0.041829176,-0.025473034,-0.022881778,0.030656839,0.019607795,-0.045528617,-0.037606742,-0.034381744,0.0050467066,-0.022444565,0.06313168,-0.011435171,-0.04035248,-0.08437094,0.027579198,0.09424791,-0.0084214965,0.03177685,0.038347315,-0.00135304,-0.018509932,-0.016383536,-0.016436702,0.05953894,0.01731704,-0.04069635,-0.039171554,0.029198421,0.02383024,-0.028215354,-0.112131014,0.06392632,0.012793436,0.062935345,-0.01942605,-0.012214584,-0.013826809,0.009773312,0.029191365,0.0149503555,-0.0034656073,-0.039922472,-0.07552255,-0.024916518,-0.0059273955,0.02231982,-0.013653314,-0.04938288,-0.020108564,0.027921468,0.16446924,0.0053871577 +3.1.1.53,"Acts on free and glycosidically bound N-acetyl- or N-glycoloyl-neuraminic acid; acts mainly on the 4-O- and 9-O-acetyl groups. Also acts on some other O-acetyl esters, both cyclic and acyclic compounds, which are not sialic acids.",384,0.99999994,-0.06355106,-0.15166375,-0.058505032,0.0047024246,0.07356212,0.07380122,0.00064904755,-0.011081347,0.10310118,-0.055545434,0.06744983,0.048002973,-0.09768557,0.026365519,-0.013099318,0.023569984,0.027733307,-0.06404011,-0.039272934,-0.016771188,0.11306029,-0.024955148,-0.019570176,-0.041656557,0.022145776,-0.033122938,-0.024425555,0.021954188,0.052297313,-0.13936807,0.010392954,-0.018439045,0.040756132,0.010465892,0.022629082,0.0009634445,-0.008918129,-0.029908713,0.055259418,0.06933059,0.045791835,-0.084938064,-0.03230459,-0.014740217,0.0574849,-0.07301257,0.0232878,0.017447086,0.0042308583,0.053085268,-0.061816458,-0.038158342,-0.028648932,0.034670543,-0.06501447,0.07713694,-0.0868803,0.022932734,0.0393008,0.072026536,0.07906154,0.012908687,-0.023508348,0.02288887,-0.13909543,0.024012128,0.10012919,-0.04472623,0.002362529,0.01284439,-0.021671453,-0.02003273,-0.010525933,-0.030006986,0.025052158,0.014475183,-0.035863582,-0.025662156,0.04678091,-0.052353054,-0.0036019296,0.01793678,-0.013390221,0.08308811,0.0306904,0.013545467,-0.030581834,-0.039880887,0.035203233,-0.011916079,-0.024779212,-0.062569186,0.013853943,-0.059434064,-0.004612976,-0.03193623,0.063215636,-0.019195668,-0.03776523,0.049324125,-0.0036892092,0.06319771,-0.020913389,-0.05663209,-0.07442994,0.104284845,0.024277842,-0.012424622,-0.0040398273,0.041727982,-0.108627714,-0.009823347,0.033351496,-0.050563395,-0.08774524,-0.0073625,-0.031129194,-0.06386465,-0.040561885,-0.038841695,0.017883062,-0.077109,0.04511584,0.079426624,-0.02775219,0.16256376,0.013676201,2.0886399e-33,0.096602075,0.047088597,0.016410025,-0.030971251,-0.0048889928,-0.034147736,-0.08442854,-0.03349764,-0.033197463,-0.028643828,0.042630974,-0.030496662,0.015447863,0.10566656,0.042147867,0.051516727,0.04756244,-0.022042394,0.062158484,-0.055374365,0.0058542914,0.12455552,-0.062378805,0.0024525102,-0.021233087,-0.011534621,-0.05783938,0.035223912,-0.037521254,0.0073628295,0.001712194,-0.005255696,-0.068482906,0.035966545,0.090010114,0.037217483,-0.11297541,-0.023411624,0.080711894,0.017826952,-0.055534266,0.0826799,0.007320921,-0.0058827093,0.015896095,0.033336885,-0.034429315,0.083210826,0.022360718,-0.017658796,0.050616708,-0.052594557,0.010931633,0.07031344,0.0023464682,0.040505975,-0.036478657,-0.035986837,-0.015782636,0.014749795,0.030307166,-0.04375462,0.0034774449,-0.05284237,-0.06842831,0.007882926,-0.074209124,0.018415255,0.06887399,-0.046344496,0.026530007,0.025682934,0.07700667,0.07879766,-0.0022601932,-0.018318022,0.023507172,-0.025848035,0.06766874,0.003134285,-0.0023620445,-0.052677758,0.0103354,-0.074274205,-0.13229868,0.015994485,-0.0011179155,-0.07035394,0.009753518,-0.0035828624,-0.0058731176,-0.058014274,-0.0003882451,0.03702184,-0.018228363,-4.1762644e-33,0.07975235,-0.044648316,0.013877833,-0.006332467,-0.057711244,0.031403884,-0.007063682,-0.022573816,-0.005067526,0.0084448485,0.020578407,-0.00228666,0.025265763,-0.07086101,0.041127693,-0.021659682,0.03845801,0.07431244,-0.0039327387,-0.021086404,0.013348899,-0.017268578,0.029181194,0.058991883,0.100159876,0.029500876,-0.04083637,0.00069412,-0.024564736,0.11681384,-0.016523788,-0.011297403,-0.05645287,-0.0614624,0.036055423,0.036943324,-0.0033932296,0.048157174,-0.0484086,-0.07580809,0.041494664,-0.010390331,0.11411921,0.08803091,0.044288684,0.07962522,-0.024630008,-0.027803047,-0.07924188,-0.033402547,0.052998528,-0.014083234,-0.016311284,0.057528764,0.059689846,0.1354127,0.039189026,-0.027466599,-0.0937631,-0.037524298,-0.05598763,0.009888495,-0.05893543,-0.063794166,0.046898838,-0.026025018,-0.028521793,0.030565707,0.057503887,-0.054680333,0.014670566,-0.025576156,0.033476796,0.046979178,-0.013722923,-0.092424996,-0.03077222,-0.10532518,-0.08891919,-0.031797826,-0.026149042,-0.018188,-0.042738967,-0.058816876,-0.124480195,-0.00842423,0.081336774,0.03784447,0.034013424,0.061577186,-0.03970088,0.06927553,-0.03369187,0.04980711,0.03249494,-3.972322e-08,0.07216757,-0.0131051075,0.09724491,-0.057854116,-0.060145803,-0.038194712,0.00375454,-0.011707408,0.016560558,0.013870382,-0.012592473,0.11913259,0.0036414398,-0.01899558,-0.026445141,-0.006786133,-0.018011294,0.028617473,-0.045817852,-0.02207008,-0.08382661,0.012475937,-0.033891357,0.012983369,-0.008310606,-0.1097477,-0.0036665793,0.05089881,-0.009404046,0.030561574,0.005014272,0.0053701033,-0.047880616,-0.061420266,-6.7848596e-05,0.070028245,0.0659473,-0.027818706,-0.0064460784,-0.0202695,-0.033282846,0.005349738,-0.041106634,0.03263851,0.028525827,-0.02166309,-0.041098136,-0.062370125,0.0040688734,0.04912184,-0.008414047,-0.05392622,-0.030118411,0.026331691,-0.13931729,-0.037912007,-0.021048706,0.007516726,0.08905449,-0.011946264,-0.030505301,0.020619059,0.096009,0.012254558 +3.1.1.54,The enzyme is highly specific.,384,1.0,-0.019712972,-0.07501273,-0.055509172,-0.022648191,0.046126816,-0.005921742,-0.08053584,0.09862333,-0.023845324,-0.010824535,0.0048581976,0.002932177,-0.10338069,0.09229017,-0.04596815,0.0498681,0.008137446,-0.028553532,-0.019973189,-0.07401858,0.045919683,0.02127124,0.03261685,0.0074526295,0.006243394,-0.016504854,0.03957905,-0.007295306,-0.020990076,-0.06642399,-0.028102292,-0.0020625128,0.07717624,-0.039421,0.011150748,0.106252305,-0.102746725,-0.05629976,0.02653688,0.012136653,0.07066076,-0.017127179,-0.0017853061,-0.029676633,-0.04945817,-0.055183433,-0.0013207948,0.007437785,0.03943116,0.06682412,-0.06947376,-0.11380329,-0.025313728,-0.025946064,0.008030721,0.0042468566,-0.08946993,-0.012276858,-0.045395434,0.030437566,0.007900978,0.009476738,-0.014993193,0.01577057,0.13614583,-0.046722095,0.026447108,-0.06273607,0.0034045384,-0.02111881,-0.030100204,-0.091900565,0.004471844,0.089960895,0.028942926,-0.01356268,-0.004106772,-0.033143852,0.040527552,0.0055874684,0.020761136,0.005094793,0.031211682,0.08807985,0.10910122,0.049598176,0.045212492,0.030862682,0.0044207084,0.041728444,0.07049138,-0.049481947,-0.027720364,-0.032297075,-0.01725076,0.03695289,-0.0087573845,-0.004274443,-0.025905045,-0.021360124,0.0017735563,0.009369328,-0.025434129,-0.047986172,-0.037284125,0.007642984,-0.027894186,0.043735456,0.04009004,-0.005240084,-0.012228576,0.052754816,0.08864458,0.025541067,-0.021766985,0.10109326,0.026270844,-0.048734087,-0.041904494,0.070731446,0.0034106604,-0.03900067,0.07499283,0.07304103,-0.030686729,0.098567665,-0.13821705,-6.605716e-33,0.044753555,0.00193732,0.016781144,0.008955222,-0.016166897,0.031548373,-0.058156468,0.024590759,-0.053978972,-0.015909934,-0.08183654,-0.058775213,0.056979526,0.033734363,0.0060251867,0.0018381176,0.006319872,0.017010316,0.025412487,0.008276985,0.01966542,0.025300723,-0.077923685,0.006824714,0.0024660788,0.043166794,-0.0007509952,0.06608973,0.036919504,-0.015270584,-0.016199775,-0.09912752,-0.06713301,0.021551369,0.05115418,0.06739569,-0.0369692,-0.046635028,-0.023317132,0.054136995,0.020153908,0.042005233,0.030301845,-0.0036839754,0.076914676,-0.05454726,-0.0884637,0.057358738,-0.013804428,0.025339637,0.052509185,-0.008018085,0.11543275,-0.030115586,-0.013587367,0.057083048,-0.02757728,0.032267187,0.05032255,0.044943657,-0.055542294,0.06943633,-0.052962746,0.06646008,-0.033164423,0.06275349,-0.08793941,-0.047221046,-0.018925233,0.14701214,-0.042400703,-0.008706969,0.045349736,-0.027635885,0.000563897,-0.054147974,-0.021320302,0.045634992,0.022821503,-0.0047473656,-0.049266975,-0.023048295,0.030967006,0.020825332,-0.12919104,-0.048060987,-0.009479306,-0.027272118,-0.0390301,0.00891307,0.094347455,-0.05692019,-0.060200896,-0.015732402,-0.024026634,4.3246147e-33,0.05228099,-0.1139785,0.06841896,-0.047023296,-0.0062418524,0.08874472,0.03836168,-0.04226941,0.044101495,0.021956567,0.10580498,0.0026693135,-0.009089012,-0.08728067,0.016414182,0.084309295,-0.09345746,0.059638448,0.0026097503,-0.028676327,-0.060427636,0.15254484,0.026555704,0.0358053,0.057319887,0.0040154424,-0.046127614,0.06430012,0.023133473,0.002713263,-0.074820794,-0.024652565,-0.08985002,-0.019105619,-0.055168808,0.04338541,-0.038216904,-0.044429123,0.035255887,0.036903962,0.0030752667,0.045046024,-0.011695844,0.07663485,-0.0005692142,0.081161715,-0.018872676,0.001546525,0.017190471,-0.01839333,-0.0098987715,-0.015690768,0.009679249,0.009674362,0.01197619,0.053217463,0.018317152,-0.02740437,-0.07631983,-0.0045069032,-0.023996271,-0.03224783,0.018159188,0.031984456,0.0006277003,0.04099776,-0.041833986,0.00715019,0.011197837,-0.02907962,0.06432539,-0.022790613,-0.00890174,0.04786094,-0.06297732,-0.05457289,-0.04421675,-0.00019912892,0.021399276,-0.046142202,-0.006694171,0.03432171,-0.023168022,-0.054743014,0.036267765,-0.010324025,-0.015543451,0.07659785,0.06348525,0.04755485,-0.046653125,-0.054692764,-0.10845556,-0.023562526,0.07938363,-1.7271235e-08,0.06741739,-0.047069363,0.035669774,-0.082752794,0.015731776,0.029871486,0.009311272,0.014318876,0.016809594,0.04652325,-0.038209528,0.116366155,-0.027927196,0.038066644,0.06068911,-0.006045889,-0.015897313,0.027555216,-0.06514479,-0.012414945,-0.07133822,0.023119127,-0.08196062,0.01716979,0.016082792,-0.07693712,-0.0012695332,0.08845082,-0.027015314,0.002956316,-0.04485439,0.0057477844,0.010554922,-0.035717603,-0.08605985,0.04100578,-0.0065757288,-0.03792095,-0.046898697,0.06284944,-0.0010123949,-0.09773667,-0.041913755,0.023370579,0.00058533164,-0.014850602,0.022414863,-0.0174028,0.04319614,0.044981897,0.028914385,-0.0038409168,-0.0069869943,-0.044095624,-0.07604896,0.022136632,-0.005999918,-0.13398878,-0.008069627,-0.11279021,0.07530375,0.03842464,0.24133492,-0.02914228 +3.1.1.55,"Not identical with EC 3.1.1.1 (carboxylesterase), EC 3.1.1.2 (arylesterase), EC 3.1.1.7 (acetylcholinesterase) or EC 3.1.1.8 (cholinesterase). The activity of the liver cytosol enzyme is highest with acetyl esters of aryl alcohols, and thioesters are also hydrolysed; the microsomal enzyme also hydrolyses some other negatively charged esters, with highest activity on esters of salicylate with long-chain alcohols.",384,1.0,0.0069313347,-0.1199635,-0.026351715,-0.016459491,0.025214644,0.025689775,-0.035037894,0.029088376,0.014639348,-0.0426194,0.031797316,-0.020534081,-0.07956697,0.027003327,-0.025258936,0.025548771,0.024674105,-0.01460214,0.0358907,-0.04039692,0.07960279,-0.04344192,0.0054757055,-0.010354096,0.05492773,-0.0021309755,0.016682783,0.022888105,-0.031055106,-0.15381531,-0.016752277,-0.035870045,0.10343441,-0.050875247,0.027970746,0.025680946,-0.040891614,-0.0849791,-0.032526944,0.022188906,0.05117519,0.032833125,-0.043520726,-0.04128076,-0.03101532,-0.050564904,0.0011670622,-0.010729001,0.0071825045,-0.018227762,-0.018934302,-0.06828733,0.0048156874,-0.026992155,-0.054490913,-0.0038402837,-0.084307015,-0.021659547,-0.027377741,0.03302384,-0.058973853,0.05679334,0.031965047,-0.03527262,-0.010368817,-0.01064885,0.07064362,-0.06787436,0.04155565,0.00013127862,-0.09662805,-0.1185684,-0.028169243,0.03389792,-0.012348426,-0.0041448395,-0.007028718,-0.07688065,0.03908174,-0.075892895,-0.04992996,-0.07704543,-0.040960528,0.06398542,0.031623423,0.017518211,-0.0009775175,-0.007139639,-0.047735926,0.087630205,0.03189852,-0.029867746,0.0045277392,-0.014001658,-0.031458277,0.0030950007,0.029714698,0.053598464,0.0136895515,-0.045813147,0.08883933,0.101680435,-0.022021696,-0.05433316,0.020925885,0.050325695,0.053680014,0.012062308,0.040036015,-0.0074448492,-0.07253481,-0.04767988,0.013765585,-0.04773815,-0.089899845,0.08130909,-0.022047866,-0.033404656,0.051993046,0.07642489,0.046627283,-1.8614803e-05,0.09315289,0.07157841,0.00973682,0.052264094,-0.07037033,2.748894e-33,0.008632911,0.033068765,0.03548634,-0.019065939,-0.024114234,-0.0078549385,-0.07511237,0.09837397,0.005379207,-0.04251411,-0.05562792,-0.0033248377,0.06944637,0.043947797,0.045127578,-0.03810903,-0.028040184,0.026225837,0.020481247,-0.028972758,-0.059825905,-0.016590603,-0.06710435,0.028855287,0.060840186,-0.055044953,-0.01520787,0.0754045,0.025779484,0.008355935,0.056801632,-0.06792234,-0.0038966544,0.06948634,-0.053924404,0.10618421,0.03161665,-0.05569735,-0.0065225456,0.06426327,0.01943489,-0.016640887,0.098445565,-0.07305476,-0.018310823,-0.08226636,-0.0886264,0.080286376,0.060496286,-0.009279384,0.044700813,-0.059891224,0.14175044,-0.018519998,0.04396125,0.07930397,-0.07386563,0.06896533,0.034143988,0.05921122,0.026170237,0.0847418,-0.068225056,0.0074650557,-0.01225953,0.09310227,-0.085875034,-0.02787871,-0.06286412,0.061859313,-0.06031655,0.041059244,0.10904948,0.018871754,0.0632699,0.022598902,-0.07740899,0.017144443,0.0077802315,0.012654216,-0.054440945,-0.003070535,0.025972905,-0.008516794,-0.038692344,-0.0103053525,0.013183177,0.039959997,0.03270855,0.10813006,-0.0024610609,-0.08134343,-0.024360787,0.07343873,-0.019488133,-3.0453743e-33,0.052017752,-0.038989745,0.01712987,-0.0438711,-0.033290885,0.07362384,0.008595639,0.02024069,0.022715304,-0.021271747,0.0713076,-0.019181374,0.027194688,-0.10955139,0.046429526,-0.03427779,-0.021654883,0.007214835,0.033174388,-0.016990539,-0.10374983,0.039350938,0.028676758,0.08387392,0.024689874,-0.040107418,-0.025196766,-0.009503967,0.022990596,0.009749458,-0.022513708,0.016861917,0.008253112,-0.011034399,-0.0692669,0.046276603,-0.05138158,-0.019646866,0.0031115669,0.0050263014,-0.03979318,0.04145816,0.036045246,0.007215661,0.075405404,0.121027246,-0.06301324,-0.017295545,0.01874281,-0.025408564,-0.025247373,-0.019417943,0.006425958,0.033411633,0.042847212,0.047558747,0.003219792,-0.01356967,0.0366097,-0.03789423,-0.025866272,0.032519624,0.012263695,-0.0067455918,0.021385174,0.0026410297,-0.101780295,0.066123925,-0.0024322215,-0.030975938,0.072938554,0.009522196,-0.02103726,0.04991074,-0.04072522,-0.033534694,0.009300811,-0.02135606,0.005903916,-0.1512234,0.11334502,0.016888011,-0.048552766,-0.023196924,-0.06535023,0.026413871,-0.025835508,0.08670472,0.025222858,0.013887604,-0.01370588,-0.02131755,-0.10736186,0.046184827,-0.0053760256,-3.946293e-08,0.076825075,0.016750751,0.036998525,-0.032526474,0.009317392,0.051373582,0.04010118,0.016812114,0.018838726,-0.03762005,-0.035423413,0.06906987,0.008604915,-0.05056292,0.042102527,0.0063759335,-0.033094186,0.045087695,0.036441907,0.0414645,-0.047969144,0.05739162,-0.07602229,0.016674832,0.018702809,-0.03853592,0.07809333,0.06343163,-0.022213489,0.018882476,-0.036743015,0.048152998,0.016425025,-0.007919173,-0.046403468,-0.021560635,-0.0671694,-0.023471732,-0.07095045,0.087028675,0.042394437,-0.10260681,-0.062094618,-0.059137646,0.061296634,-0.054911535,0.047175936,-0.016630847,0.03983581,-0.10269144,-0.05668276,-0.03315804,0.011441845,-0.046324603,-0.022947337,-0.028680736,-0.030154686,-0.12325532,-0.0030146854,-0.07373974,0.08516596,0.012784924,0.18347405,0.08086137 +3.1.1.56,"Acts on short-chain acyl esters of 4-methylumbelliferone, but not on naphthyl, indoxyl or thiocholine esters.",384,0.99999994,0.006840797,-0.089172155,0.020608202,-0.039303027,-0.013760518,0.04686692,-0.053040426,0.0014204062,0.072419845,-0.041219205,0.10032248,0.008117785,-0.06869142,0.01583134,-0.006423154,0.13766457,-0.07062123,0.03214151,0.018699883,-0.05436484,0.03523145,-0.03362121,0.008795512,0.022123227,0.0021147758,-0.04296704,0.027832787,0.0494516,-0.06779459,-0.14085023,-0.03785707,-0.028982572,0.018849391,0.012351939,0.04547511,0.047658972,-0.020518525,-0.013330002,0.15084901,0.01713616,0.09556675,-0.09068722,-0.036117576,0.023612887,-0.056980424,-0.034227807,-0.01738342,-0.0077279103,0.019690998,0.009861338,-0.06331,-0.019733237,0.01801836,0.046447117,-0.073407754,-0.004649477,-0.035492714,0.01573785,-0.037203196,0.072770424,-0.008223489,-0.0182635,-0.035773024,0.02236866,-0.054319236,0.048669424,-0.011122518,0.029561691,0.023268536,0.05559894,-0.0029858095,-0.058317382,-0.01906159,0.051896248,0.012623712,-0.013608152,0.012436199,-0.062620275,-0.008555802,-0.10271042,-0.017727556,-0.0002620936,0.03611365,0.01864751,0.012731201,-0.024318518,-0.020424757,-0.043033764,0.02068754,0.08823905,0.06233076,-0.024171432,-0.04009802,-0.027654856,-0.014310442,-0.007222742,0.05019798,-0.03416681,-0.036305454,-0.027636658,0.06609467,0.0075045777,-0.11009239,-0.08329064,-0.048243277,0.03774895,0.035204727,-0.06506585,-0.062128913,-0.023222031,-0.048817154,-0.018025495,0.057391357,-0.017402563,-0.12445473,0.0007025436,-0.01891416,0.010059978,-0.07077425,-0.032185037,-0.045485493,0.0074862274,0.055691037,0.062161624,-0.03022893,0.010519153,-0.07190908,2.4095324e-33,0.046281513,0.072705634,-0.018287616,-0.03845056,0.014135782,-0.050035555,-0.078637876,0.034118373,-0.10418016,-0.02749507,-0.023162883,-0.12518476,-0.03537892,0.00036659234,0.05584287,0.004768697,0.024864558,0.05496089,0.03202646,-0.041345812,-0.07307397,0.053546306,-0.067368664,-0.00030241936,-0.05970212,0.0005216222,0.01942381,0.087350786,-0.019438699,0.00375928,0.022601416,0.018291583,-0.018310148,0.036546998,0.053588197,0.057317015,-0.03770523,-0.0014205636,0.005234719,0.056107163,-0.020745026,0.08994982,0.015464899,-0.02597096,-0.008598402,-0.056240253,-0.04179978,0.13598974,0.10599434,0.084307514,0.009200693,-0.03951164,0.09465675,0.010915662,0.009435713,0.021051822,-0.101402044,-0.0059457025,-0.013930789,-0.00037835503,-0.01115137,0.0095019,-0.05343681,-0.10025544,-0.020690354,0.029053994,-0.040303696,-0.02597729,-0.04800179,0.055767667,0.040788207,-0.0027703962,0.07020116,0.05194707,0.08665359,0.004980084,-0.11380751,-0.037112106,0.08329294,0.0021150846,-0.0045262454,-0.012705519,0.075383745,-0.030553048,-0.037521616,0.014737332,0.034331016,0.035378546,0.04960548,0.08812378,0.048764855,-0.094064824,-0.054971777,0.06831741,0.049438417,-4.374816e-33,0.043126434,-0.009124106,0.04408984,-0.07131783,-0.085072316,0.064056754,-0.03401214,0.033184253,-0.010196325,0.055834875,0.12916672,0.0066256626,-0.021483354,-0.046870884,0.0077223335,0.0062398263,0.006661878,0.037784554,-0.017659087,-0.018668309,-0.030089471,0.012284425,-0.008798606,0.13203374,0.006325853,0.03541236,0.00959825,0.103291936,-0.0077644396,0.045588423,0.028463267,-0.03598408,-0.030221252,-0.038532555,0.04851465,0.107367195,-0.042435933,0.04368605,-0.00919162,0.04948048,0.003339796,-0.006944193,0.039904706,-0.014218622,0.048406985,-0.026765926,-0.05103112,0.0017638304,-0.029134708,-0.071474805,-0.013940847,0.033244867,-0.00020451029,-0.004541939,0.010196869,0.073273666,-0.055298597,-0.069625646,-0.03101658,-0.10760245,-0.08418666,-0.062535666,-0.017287036,-0.04161939,0.022902446,-0.02521012,-0.034817185,0.014274994,0.07680166,-0.007077348,0.044132445,0.004584451,-0.0076599647,-0.018352492,-0.053093184,-0.06904036,-0.02297972,-0.12380921,-0.06513144,-0.035099402,0.033716545,0.0006549573,-5.4533295e-05,-0.08741538,-0.07979239,0.03224439,0.017131891,0.05140176,-0.03346927,0.07391432,0.07874332,0.10333207,0.018409442,0.055954825,-0.02307326,-3.2479335e-08,0.08984392,0.0028750123,0.11566272,-0.011687168,-0.047592785,0.03105237,0.005453393,-0.013033285,0.050948113,0.000463,-0.11321353,0.104479186,0.0021321827,0.017908854,0.052625734,-0.07493154,-0.025142986,0.01988673,-0.032074366,-0.026295785,-0.11065039,0.040309023,-0.08707079,0.041212197,-0.022556258,-0.0121247545,0.07098807,-0.013737124,0.027135719,0.062064983,0.07755595,0.07009289,-0.037064433,-0.039856654,-0.024035124,0.038215805,0.013545756,-0.025179895,-0.055701893,0.040930334,0.029533483,-0.058055803,-0.06516505,0.0609977,0.06003243,-0.042099103,-0.001179652,-0.05689452,0.029635802,0.017624382,0.021745909,0.0032130464,-0.008069187,-0.0439302,-0.059878215,-0.03209453,-0.016042681,0.024065547,-0.010706854,-0.056173168,0.02132679,-0.044066597,0.124448724,-0.019353876 +3.1.1.57,"The product is most likely the keto-form of 4-oxalomesaconate (as shown in the reaction) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC 5.3.2.8, 4-oxalomesaconate tautomerase [3].",384,1.0,0.015291543,0.022354644,-0.030563436,-0.038322706,0.0018808917,-0.0017392633,0.04596137,0.024381027,0.0079499,-0.025674552,0.008679486,-0.098661534,-0.013312444,-0.0667472,-0.027036875,0.062026028,0.009679094,-0.01971895,-0.017656125,-0.017016556,0.103840604,0.02439996,0.046572823,0.052370626,0.055665173,0.05071686,0.06396616,0.010092857,-0.035910364,-0.1335076,-0.0006632485,-0.012233741,-0.048411604,-0.036946442,0.0629807,0.042827744,-0.06160083,-0.061003532,0.050748065,0.017379522,0.057499073,-0.075728975,-0.056782503,0.014296282,-0.008320728,-0.04186818,-0.06877385,0.04516384,0.048380896,-0.009822247,-0.024992773,-0.090899214,-0.05455693,0.0391463,0.061978642,-0.034085426,-0.07394397,0.054536454,-0.012848383,0.054285865,0.073515676,-0.008209947,-0.0015525161,0.018741127,0.0010409679,-0.015168296,0.03282678,-0.09764732,-0.036353603,-0.05276953,-0.05600509,-0.07165286,0.048121434,0.043476913,-0.004759798,0.025862811,0.048798107,-0.028738642,0.038996648,0.018918457,0.047000024,0.061280012,-0.028411511,0.05432036,0.020465786,0.0076990984,-0.012447388,-0.06936907,0.06918317,0.04071019,-0.030252922,-0.02436622,-0.009989684,0.025768993,-0.0784589,0.039877355,-0.0018774337,0.005217725,0.07309495,0.045039847,0.009629702,0.0065510278,-0.016056515,-0.10431565,-0.064783506,0.003264416,0.0045104437,-0.01989445,0.031291746,-0.0039706146,-0.11259669,-0.09848252,0.01664687,0.019307237,-0.09664722,0.05994015,0.01141606,-0.026798991,0.015534248,-0.06741585,0.0057982565,0.011128208,0.099966936,0.008676236,-0.083782226,-0.011981768,-0.0767862,-1.4336699e-33,0.0493879,0.007138387,0.09170434,0.027522394,-0.00200773,-0.0022374468,-0.05148304,-0.0013665848,-0.020107688,-0.06313752,-0.14598964,-0.093576126,0.037541974,0.05221142,-0.047940318,-0.04849331,-0.08085504,0.014321641,0.039059334,-0.015093862,-0.041307196,0.068224125,-0.06253517,0.02267957,-0.11398475,0.0075963843,0.029913142,-0.019906314,0.05985774,0.014516693,-0.021139119,0.0051882337,-0.063794404,-0.061365355,-0.018859182,-0.018750409,-0.023087867,-0.028404435,0.020446092,0.109285004,-0.005566964,-0.0094038285,0.043622654,-0.045173865,0.016553856,-0.0006701905,-0.006810334,0.06976329,0.11705891,0.0017449083,0.022197708,-0.06854454,0.10964099,-0.032825157,-0.022732794,0.02661942,-0.04661948,0.029258145,0.076410346,-0.011245536,-0.067113936,0.08306522,0.008428641,-0.010795454,-0.035914175,-0.025255194,-0.09721185,-0.061774798,-0.047455903,-0.032653715,-0.0064963116,0.033253968,0.060457703,-0.016862573,0.051330548,-0.06526468,-0.042231582,0.048782717,-0.024686366,0.010597903,0.047353003,-0.0133572845,0.02309067,-0.01596655,-0.0073364866,0.03260355,-0.034181356,-0.050561026,0.025457231,0.14301325,0.045016903,-0.06256817,-0.07338012,0.018785706,-0.0029024836,6.532037e-35,0.09399389,-0.04510399,0.043328155,-0.0143577205,0.045519944,0.0132716745,-0.016168874,0.030703854,0.047188982,0.054278728,0.088188,-0.004918715,0.12685664,-0.04081922,0.043141853,-0.0043297946,-0.0290142,0.03460119,-0.023765113,0.024694273,0.032261632,-0.02125868,-0.07222538,0.017652456,0.036248695,0.04174896,0.07045804,0.029531857,0.06090792,-0.016883476,-0.027112214,-0.076698616,-0.015542762,0.041697208,0.001293545,0.020690124,0.019161973,-0.09228228,-0.01547183,-0.019563599,-0.09095463,0.05977193,0.023463942,0.012491642,0.05005093,0.050070427,0.00976977,-0.047566965,0.024931202,-0.006642203,0.061251123,0.009399873,-0.09448482,0.010101739,0.0073135183,0.021716736,-0.07123154,0.0029446888,0.03884974,-0.006215407,-0.025089504,-0.043232013,0.12943229,-0.069257006,0.080788024,0.05684755,-0.03593663,0.042966567,-0.015919168,0.03884933,0.08091803,-0.035094768,-0.057122905,-0.033502396,0.08691801,-0.05958758,-0.056275122,-0.036158405,-0.0694586,-0.06754201,0.025307503,-0.049879286,0.021251341,-0.045873858,0.001177783,-0.08819531,0.048249174,0.0931755,-0.028438369,0.079627566,0.0020112423,0.023808595,-0.068930544,0.16667712,0.11644265,-4.0299845e-08,0.027195217,-0.05845985,-0.0005502242,0.031172318,0.02317644,0.04436953,0.043105092,0.0004820852,0.08633977,-0.11463319,0.008956551,0.069542944,0.020879962,0.005724172,0.02020986,-0.009257006,-0.07122388,0.05786234,0.008098841,-0.0038803348,-0.035280917,-0.048127547,-0.019766,-0.025044663,0.030258652,-0.028835421,0.030210799,0.08363167,0.008237892,-0.092828274,-0.049471054,0.048376366,0.004631594,-0.07236337,-0.088352494,0.04758495,-0.06641354,0.062103048,0.00030237628,0.037628766,-0.03825168,-0.055758424,-0.039722078,0.024835596,-0.036035366,-0.00854409,-0.017381368,0.033045918,-0.04852529,-0.06121537,0.0015827424,0.012449415,0.02333634,-0.011534304,-0.066357,0.016740918,0.02196252,-0.010505727,-0.005323886,-0.05889664,-0.024540387,0.02690392,0.14781016,0.082020335 +3.1.1.59,"Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.",384,1.0,-0.094717965,-0.07235484,0.016434446,-0.0077174543,0.03752482,0.045995153,-0.026436862,-0.060594697,-0.045456823,0.0004494551,0.0919816,-0.04526217,-0.05197563,0.017090255,0.055724062,0.095860355,-0.026575608,0.08663446,-0.039984215,-0.087272674,0.038242716,0.037017383,-0.016513864,-0.00456024,0.082367815,0.0129722,0.06429014,0.07398535,0.038193807,-0.08587066,0.012977461,-0.04051107,0.005169431,-0.086279586,0.06821431,0.05970938,-0.06837235,-0.06703212,0.078405246,0.036241617,0.07795844,0.0386461,-0.073607035,-0.11823814,-0.12349793,-0.051810067,-0.004032585,-0.009907251,-0.015846053,-0.0024766198,0.033001497,-0.09048514,0.027158242,0.05597564,-0.0022023232,-0.078125775,-0.019450855,0.05066689,-0.05964024,0.041993007,-0.028892614,0.057294723,-0.012722407,-0.011406272,-0.076269194,-0.04738112,0.02884991,1.4273051e-05,0.046477005,-0.06168283,-0.05591753,-0.052710507,0.00789085,0.016902586,-0.08437355,-0.046091445,0.029379979,-0.061353736,0.091939695,-0.030417802,-0.10621851,-0.04074905,0.02784288,0.08289556,0.0056247143,0.002654354,-0.0140777305,0.022133913,-0.010971004,0.067327596,0.0038627107,-0.046147354,-0.028558932,-0.025849584,-0.01532976,0.06178857,0.007778728,-0.06531099,-0.007203274,0.015630964,-0.045149814,0.058488354,-0.040329184,-0.0070516965,-0.07061569,-0.026411524,0.03260619,0.0047483714,-0.018919108,0.016274769,-0.048568957,-0.015302943,0.09873997,0.08390143,-0.10154285,0.009462664,0.004061771,0.01343767,0.034008227,-0.09643422,0.059352133,-0.0005906249,0.10643711,0.048028886,0.038219772,0.014375726,-0.09884657,1.22678705e-33,0.044351738,0.011332467,0.02396999,0.02047226,-0.06605512,-0.030361358,-0.090269156,0.08958268,-0.009362375,-0.07951642,-0.09149651,-0.01554681,0.0024819882,0.015113858,0.016302798,-0.038648847,0.048818305,0.043811593,0.078475215,0.015079055,0.020067694,0.04496853,-0.01622399,-0.035491206,0.0022305087,-0.013083573,0.039620012,0.038259182,-0.003356026,0.017783104,0.019995863,-0.095331684,0.009572492,0.07829268,0.04145813,0.06897272,-0.007531744,-0.07175951,0.026526038,0.009725921,0.015567534,0.00017667818,0.026622454,-0.080176234,-0.02544468,0.017688638,-0.083574116,-0.03937687,0.019624816,0.058183257,0.053691898,0.05972335,0.119607545,-0.036966827,-0.00962572,0.055365417,-0.023018591,-0.02667754,-0.0130444905,0.019087618,-0.09743279,0.031878736,-0.015878009,-0.08282912,0.0698428,-0.0015785425,-0.05490566,0.01212356,-0.03146062,0.01431972,-0.01887266,0.030274272,0.08150141,0.033090264,0.027160931,-0.020762898,-0.032631207,0.09896217,0.076815575,0.0037689053,0.024919035,-0.04333267,-0.041693024,-0.003055463,0.00021187348,-0.022315431,0.055124294,0.059448186,0.12941095,0.07715601,0.032482367,-0.07081947,-0.0041357838,0.03149572,-0.03217189,-2.6945752e-33,0.0044139093,-0.039291427,0.010446688,-0.06381572,-0.023660904,0.0040128655,0.05879284,0.021402467,-0.003478038,-0.012180686,0.0060792677,0.080462836,-0.030431353,-0.098602735,0.04765831,0.002610949,0.032647964,0.043607716,0.006579657,-0.03773864,-0.019049976,0.07284202,-0.018875206,-0.0015579626,0.07502732,0.018150432,0.02811832,0.11323582,0.052894462,0.07827939,0.0381289,-0.004949234,-0.008508516,-0.10507466,0.022301534,0.0106123295,-0.062038545,0.011736249,-0.06277558,-0.023061888,-0.027035885,-0.00049493037,-0.015115473,0.04699386,0.0667981,0.05137422,-0.060441893,0.0065526636,0.042878296,-5.4775675e-05,-0.03335488,-0.022101205,-0.021986261,0.019106073,-0.0124136405,-0.031209955,-0.015916748,0.0181968,-0.00054945354,-0.043191906,-0.05670179,-0.051068135,-0.018229567,-0.021677345,-0.08359466,0.03349319,-0.015893864,-0.017342048,-0.01118697,-0.040246297,0.12207159,-0.023216411,0.0734237,-0.027777284,0.019317234,-0.10689531,-0.02593488,-0.022518402,-0.06900241,-0.056834444,0.10033236,0.04959835,-0.13105415,-0.03665877,-0.033464123,0.016415987,-0.02027456,0.061296333,-0.024343649,-0.062143072,-0.0428512,0.014971835,-0.039424397,0.11170151,0.06727342,-2.6226683e-08,-0.011537134,-0.0614934,0.06659229,-0.045869455,-0.08292603,-0.017674662,0.03210756,-0.0079052085,0.03581566,0.0023846815,0.062744446,0.13612463,0.054224137,0.0048619914,0.0038317677,-0.040990774,-0.014726284,0.0607275,-0.020043936,-0.008823467,-0.039694782,0.07027098,-0.06288002,0.0032892914,-0.018011346,-0.060073197,0.0028088165,-0.038288094,0.008349007,-0.044109803,0.05667687,0.096464865,0.09794459,0.008544967,-0.052220833,-0.022056792,0.009975327,0.019510573,0.0034621903,-0.0052816537,0.014521928,-0.04725178,-0.028906284,0.011876528,0.056363557,-0.0070886854,0.010678637,0.05161656,-0.0018270948,-0.022467906,-0.01779628,0.01870219,-0.013631256,-0.061639287,-0.036213595,-0.08230566,-0.040297117,-0.043225095,-0.022198293,0.007338848,0.044257443,-0.058343954,0.18245746,-0.01925501 +3.1.1.60,"Also acts on 4-nitrophenyl esters, with optimum chain-length C6 to C8.",384,1.0,-0.012324146,-0.045047946,-0.011643116,-0.013029611,-0.014024687,0.0698964,-0.07670523,0.022961231,0.073980756,-0.062941715,0.02665871,0.009028259,-0.123262025,0.024765098,-0.0057139285,0.07406427,-0.06169669,0.06291258,-0.04854479,-0.048803188,0.009709903,-0.053563274,0.045848705,0.0077769747,-0.05420325,-0.047933355,0.033441875,0.023353938,0.030733727,-0.13263069,0.05968947,-0.026367573,-0.023005791,-0.008133608,0.047581848,0.020277534,-0.010545519,-0.014312989,0.06429358,0.007304034,0.11246508,-0.03310417,0.04481231,0.0014161691,0.0057069464,-0.02284554,0.0011553521,0.02174095,0.07381544,-0.029738225,-0.029951468,-0.06472863,-0.0074245096,0.047783524,0.03446404,-0.016428426,-0.20110635,-0.05333906,0.10136194,0.0667305,0.08313353,0.030467698,0.03722701,0.037845097,-0.058038533,0.011653501,0.06299402,-0.0155339595,-0.04491546,0.016019808,-0.053826638,-0.03899555,-0.05754474,0.03491149,-0.013972086,0.029401654,0.0031588527,-0.080875605,0.014407793,-0.053768206,-0.03683089,0.025179813,0.056684524,0.06770083,0.04544442,-0.0055765887,-0.010052326,-0.0745699,0.010809469,0.04926524,0.017100789,-0.004851488,-0.022937067,-0.07126427,-0.016171528,0.0027308427,-0.0072547896,0.012971111,0.008229432,0.032255847,0.056786165,0.017894149,-0.04986775,-0.039084043,-0.11049317,0.020434743,0.019704195,0.055311915,0.025936168,0.02797488,-0.032160085,0.010668191,-0.0051823137,-0.027279355,-0.105655916,0.030786924,-0.06477664,-0.021552464,0.0002552033,0.033799775,-0.039670233,0.02583642,0.018389704,0.049189754,-0.108330436,0.0828515,-0.030518932,1.8006808e-33,0.01626039,0.07589006,0.040189,0.03935622,0.03299043,-0.04593869,-0.14174528,-0.039987467,-0.0755862,-0.04811442,-0.054610193,-0.059580136,-0.007087791,0.024834966,0.07170336,-0.0551005,0.023223542,0.11105199,0.04692102,-0.07718792,-0.014846687,0.10211189,-0.05727012,0.02846538,0.048171997,-0.04120314,-0.015723284,0.03286079,0.03452611,-0.04668284,0.0045380276,0.02011213,-0.00458849,0.0054886546,0.076271534,0.008625652,-0.09851931,-0.032365818,0.007668328,0.051416878,0.03742821,0.05361188,-0.0053964313,-0.013023994,-0.019489776,-0.00078196893,-0.05117227,0.030129593,0.067586415,0.02030913,0.07196481,-0.0062341406,0.07445837,0.038481537,0.028043937,0.03782457,-0.04003234,-0.041863903,0.06986714,-0.038468394,0.00016818556,0.034704287,-0.049835555,-0.07016086,0.06405033,0.04061575,-0.03905506,-0.031337924,-0.012708278,0.044269428,-0.038685925,-0.011615863,0.107616365,0.07139775,0.107997715,-0.02405624,-0.13024482,-0.066690534,0.10102929,0.0023746314,-0.012754056,-0.0021781016,0.0059451615,-0.04605963,-0.0011866122,-0.07241696,-0.06707906,-0.052772142,0.043172743,0.023046348,0.08308845,-0.10682691,-0.057891928,0.029705279,-0.03904784,-2.9437914e-33,0.03572354,-0.044820152,0.029458202,0.0373531,-0.022655195,0.028226461,0.030545164,-0.042798545,-0.042726267,-0.041328512,0.15096742,-0.015585022,0.022166511,0.02665249,0.023005825,0.04809599,0.026554672,0.00042686771,0.013332486,-0.04386771,0.028629374,0.00041378275,-0.030230386,0.09825829,0.030033723,0.06274862,0.035792425,0.03340271,0.06178095,0.05108529,-0.050431136,-0.009703345,-0.048138104,-0.024979353,0.016621038,0.06760241,-0.021089267,0.07512904,0.00060808833,-0.002497548,0.03550007,-0.00018252185,0.039665412,0.09183467,-0.037021756,0.0015184795,0.033674397,-0.01541985,-0.051997818,-0.011186151,0.0092147915,-0.007231954,-0.057095237,-0.018625606,0.014762375,0.005373666,0.014237465,-0.08133689,0.020728223,-0.016032232,-0.087323405,-0.027894028,0.06095823,-0.056080136,-0.008878982,0.04077475,-0.07453098,0.038717616,0.015150378,-0.09366841,0.0862215,-0.0063250754,0.06505114,0.030453892,-0.042732123,-0.09308298,0.0908517,-0.12760492,4.983632e-06,-0.03160749,-0.05220704,-0.040578622,-0.010553561,-0.06679148,-0.06883351,-0.016083308,0.073558874,0.017043637,0.039666843,0.039948627,0.062490754,0.066407815,0.03377399,0.061021242,-0.050868805,-2.7471385e-08,0.025036553,-0.066652775,0.10996254,-0.051042058,-0.018900631,-0.014963194,0.047539443,-0.015464628,-0.016561272,-0.07345251,0.061421286,0.09970061,0.0077099567,-0.03435852,0.057429045,-0.054879174,-0.08825738,-0.013939249,-0.039095912,-0.035029028,-0.121746294,0.028909283,-0.031887386,0.0134658795,-0.02156594,-0.088249885,0.031162878,0.06633156,0.010449283,0.009761911,0.04140766,0.07066042,-0.027241087,-0.016332198,-0.00040143591,0.025971876,-0.025761947,-0.0058594528,-0.061178897,0.053962674,0.007671186,-0.06855717,-0.020106245,0.008596665,-0.023628956,-0.0077723204,-0.07792902,0.03012234,-0.015881946,0.08939485,0.033651434,0.0070662023,-0.007921614,0.006385517,-0.07173183,-0.067979254,-0.028547011,0.009043288,-0.0055060764,-0.047367275,0.006376993,-0.055600457,0.10688704,0.010775143 +3.1.1.61,"Hydrolyses the products of EC 2.1.1.77 (protein-L-isoaspartate(D-aspartate) O-methyltransferase), EC 2.1.1.78 (isoorientin 3'-O-methyltransferase), EC 2.1.1.80 (protein-glutamate O-methyltransferase) and EC 2.1.1.100 (protein-S-isoprenylcysteine O-methyltransferase).",384,1.0,-0.035981137,-0.033211324,-0.06015564,0.0060037123,0.046191372,0.01583847,-0.029583791,0.08354604,0.06640559,-0.12365063,0.07119557,-0.04024818,-0.060883947,-0.017837092,-0.03698176,0.0106980605,-0.06034909,0.0047834297,-0.037867103,-0.056045886,0.111694984,0.060501657,-0.042612154,0.015475445,0.06355582,0.019386252,0.00024338817,-0.01710062,0.06322625,-0.10228824,0.03422202,-0.0933523,0.061494954,-0.06273978,0.09127594,0.058186576,0.05099127,-0.107431546,-0.016103784,0.0019087918,0.0908605,-0.009188181,0.012448996,-0.07468437,-0.039348114,-0.0381652,0.036674473,-0.0028567659,0.006059212,0.00858857,0.031403292,-0.08645371,-0.08561563,0.061601616,-0.0055030785,-0.072773024,-0.038619585,0.014578876,-0.04712532,0.043157414,-0.03528144,0.07457591,0.031502675,0.018565955,0.022359587,-0.046586607,0.059940457,-0.052421484,0.014085972,-0.056772202,-0.07777802,-0.06261636,0.0062592253,0.08588345,-0.037034698,-0.004389364,-0.027511938,-0.007956276,0.034586467,-0.05860862,0.008051131,-0.02963369,-0.003054977,0.029358365,0.009272529,-0.037844345,-0.07312948,0.047784775,0.028970867,0.051011357,-0.0039629354,-0.04246469,0.0881314,0.006679118,-0.02714496,0.032483324,0.054752823,0.04584067,0.02539906,0.005918069,-0.044463426,0.1031988,-0.104741625,-0.05967019,0.044009767,0.036049463,-0.019858126,0.07184954,0.012722514,-0.02778571,-0.0083344625,-0.03697712,0.042088866,0.016304856,-0.050941277,0.003467969,0.021525001,-0.016038395,-0.019697962,-0.02178158,-0.040645037,-0.048695616,0.115622774,0.080824986,-0.004408935,0.03356046,-0.05380931,1.9348088e-33,0.04425927,-0.038424224,0.03990409,0.0070059653,-0.07750456,0.0039627436,-0.06901936,0.03993856,0.05508778,-0.0843165,-0.10674709,-0.0733641,0.0037087717,0.09180494,0.049256314,-0.038822815,0.05990419,-0.037599187,0.031902622,-0.0072608837,-0.008254735,0.06324538,-0.031074136,0.010481352,0.020141352,0.00340783,-0.021848483,0.00040991156,0.040045608,0.0028038546,-0.013163509,-0.12807888,-0.070095144,0.0007205808,0.015237357,0.03252237,0.008553039,-0.03562937,0.030841155,0.075006925,0.007986917,-0.022486065,-0.01700495,-0.086081415,0.011048669,0.041703727,-0.034769602,0.029529192,0.050398555,-0.0052324473,-0.02503194,-0.041706204,0.056624625,-0.031343143,-0.09093032,-0.060885645,-0.046968166,-0.037801813,-0.008911612,0.08409684,-0.07964649,0.08194142,0.0007679287,-0.020428728,-0.06776509,-0.019011367,-0.029735075,-0.06436482,-0.034796607,0.0106891105,-0.117251374,-0.008692481,0.1287959,-0.025965653,0.048084136,-0.08476094,-0.018124271,0.02198228,0.028015977,0.06859413,-0.03658773,0.043561682,-0.015424084,-0.019546896,-0.023785114,0.041745115,0.008923359,-0.039134834,0.019083792,0.07248101,-0.012592637,-0.03451525,-0.01868681,0.021176703,-0.02501354,-4.4901805e-33,0.01775154,-0.06356188,0.030036388,-0.081785716,-0.01105617,0.03715217,0.016503306,0.0787037,-0.00057134137,-0.01348225,0.055187654,0.0005305981,0.0037805315,-0.101922244,0.008399843,-0.008405336,-0.032690052,0.08012512,0.030305456,0.01438422,-0.013070832,-0.005385908,0.013899325,0.08077796,0.087951876,0.021444734,-0.0065190224,0.0041926093,0.046636894,0.072982244,-0.012551831,0.019301487,-0.03305115,-0.030006206,-0.0706941,0.04111194,-0.041436598,-0.02710066,-0.027149446,-0.016510481,0.007295054,0.06687518,0.008645056,0.05055592,0.051244963,0.098382704,-0.014797607,-0.0081224665,-0.041920688,-0.007956912,0.040559422,-0.019319924,0.016950883,0.084504664,-0.01087029,0.011522598,0.01012062,0.071165524,-0.044794586,-0.024919653,-0.04357805,-0.05735526,0.014102813,-0.009904246,0.021643845,0.025401276,-0.009123223,0.04918927,-0.008568743,0.0010350989,0.05349716,-0.07050983,0.018734822,0.035184085,0.036191765,-0.051728945,-0.1159298,-0.056760777,-0.035528746,-0.07511078,-0.046818823,0.027978977,-0.017049158,-0.07008623,0.022717724,0.011329575,0.020130822,0.09828232,0.010210457,0.073062,-0.05061073,-0.0049329964,-0.101799875,0.099555485,0.062173497,-5.1099136e-08,0.004260022,-0.13090499,0.064636804,-0.03600208,0.0009511268,0.09243177,-0.029759603,0.05290557,0.028555354,-0.023175133,0.028318599,0.0525502,-0.08810612,-0.06900613,-0.04311268,0.031658657,-0.04064913,0.09496697,0.020848935,0.025644913,-0.03996253,-0.0039863307,-0.046451267,0.04288344,-0.013101139,-0.026058294,0.061535716,0.08472043,0.028095601,-0.06052873,0.065573,0.02419387,0.031483416,-0.037789345,-0.02452413,-0.026354846,0.023915695,-0.04005663,-0.045961153,0.06787723,-0.022010121,0.0003376537,-0.04139093,0.0020803618,0.10122596,0.028543534,0.027276928,0.093744755,-0.04032285,-0.06371383,0.07575748,-0.084063396,-0.052366152,-0.08324766,-0.06593541,-0.050203193,-0.062456574,-0.07954751,0.0022934582,-0.019396951,0.054194693,0.024396826,0.19702786,0.014757036 +3.1.1.63,Activated by bile salts.,384,1.0,0.036768436,-0.068613134,-0.031471483,0.02263043,-0.05513662,-0.018262774,0.1406709,0.05870324,0.06086775,-0.02952031,0.071892835,0.013520077,0.0142083755,0.0020993673,-0.081324495,0.06734171,0.052240815,0.055678327,-0.06684828,-0.07796967,0.04898764,0.004868175,0.017744664,0.011036039,-0.042430524,0.07054904,0.096458174,-0.034298215,0.006890998,-0.023782222,-0.038158666,-0.00849683,0.09165902,-0.06835367,-0.09629683,0.0018270083,-0.029532146,0.060386226,-0.0031231735,0.035366274,0.052313335,-0.0843172,-0.011459357,-0.071079925,0.015712405,0.007054004,0.025824869,0.05255852,0.06713998,0.02804753,-0.0039958768,-0.021247247,0.025201261,0.004098671,-0.005174519,0.04137489,-0.063408986,-0.03806251,0.026662316,-0.049665663,-0.049225524,-0.008589076,0.0481887,-0.0042192736,0.044940945,-0.061345417,0.035195168,-0.053934958,0.09881803,-0.02869852,-0.028953897,-0.04224855,-0.02043103,-0.030034851,-0.01024118,0.0007355408,0.022897381,-0.09962246,0.048232146,0.059596203,-0.029150922,-0.025234202,0.08184949,0.10288737,0.09135736,0.056858826,-0.0033535594,0.023929982,-0.057250235,0.020284604,-0.0026310384,-0.05392528,-0.02523412,-0.030038582,-0.047139574,-0.07365003,-0.026451342,-0.042586453,-0.03444907,0.064660855,0.013729529,0.055507153,-0.016961168,-0.06998753,0.00027310336,-0.042937968,0.040963117,0.013746989,0.02407262,-0.032948,0.029629031,-0.0423331,0.04407152,-0.038479358,-0.11512528,0.19650294,0.016342891,-0.04613953,-0.038946506,0.06473491,-0.022498734,0.029434618,-0.047053747,0.01870797,-0.028987925,0.018378755,-0.025213892,-3.999901e-33,0.0026212358,0.012495919,0.037366804,0.030062975,-0.022595119,-0.03837225,0.0014764598,-0.07135497,0.09578296,-0.058673356,0.059028585,0.0013448341,0.0033030505,-0.0061372533,-0.02385785,-0.021222597,-0.02223176,-0.0154535575,0.1181499,-0.03864455,0.0037881895,0.04983228,-0.021664659,-0.014351086,-0.006005459,0.030454315,-0.05153511,0.02767796,0.017607711,0.023790564,0.033267807,0.011086866,-0.054201487,0.05923542,-0.043284256,0.111612424,-0.04635401,-0.0233268,-0.021407837,0.061404556,0.034165416,-0.050581463,-0.07209049,0.048533425,0.050526164,-0.04714119,-0.1117332,0.0654287,0.07334058,0.056943104,0.095229916,-0.037434913,0.008052534,-0.044215098,-0.017023223,-0.029747043,0.020630732,-0.048342027,-0.04812879,0.03292246,-0.021953903,0.09740578,-0.10503645,0.102712214,0.002959517,-0.014773231,-0.028460205,-0.06264303,-0.023514474,-0.025398847,-0.063183405,0.014169037,0.048648477,0.0022830428,-0.12761119,-0.0040399865,-0.0417368,0.0071865325,0.0017679377,-0.0018035349,0.028766502,-0.06945882,0.041178554,0.03512948,-0.055120397,0.02084849,-0.04260866,-0.03870172,-0.034130555,-0.027940353,0.015451292,0.018711781,-0.083961435,-0.010786488,0.013257114,1.5187786e-33,0.022839854,-0.06775237,-0.041813873,0.08712824,-0.0046112537,0.039171677,-0.0008859122,-0.051728923,-0.016236072,-0.042695638,-0.00536498,-0.036389083,0.019658372,-0.0060866373,0.043672755,0.039606787,0.08393338,0.11767098,-0.066306956,-0.008443658,-0.06157416,0.08839532,0.0700283,0.106160745,-0.03750297,0.016468842,0.09144735,-0.057471514,-0.009075191,0.091677085,-0.0018690842,-0.00935297,-0.042001955,-0.047609944,-0.04684977,0.008331614,-0.056067828,-0.013901175,-0.037964214,-0.028979938,-0.03910733,-0.024198433,0.07659232,0.08872299,-0.064293236,0.07237976,0.05162594,-0.02699922,-0.06372036,-0.02271444,0.05728558,-0.016720213,-0.00084088143,0.04472371,0.0087207705,0.06849557,-0.031660873,-0.05542424,0.040898878,-0.045529004,-0.034392156,0.03414388,-0.0018114934,-0.06940813,-0.01813537,5.585024e-05,0.0071000378,-0.0053651957,0.008638541,-0.028401628,0.059724174,0.03933261,0.06203348,-0.0021930197,-0.042199522,0.034276146,-0.041987598,0.027667679,0.012507518,-0.113403104,-0.09880999,-0.006721835,0.010650896,-0.045673553,0.023273554,-0.072590135,-0.096474014,0.050939202,0.0040114983,-0.030981638,0.008413022,-0.04548748,-0.106183775,-0.0023601118,0.026251584,-1.2604354e-08,0.006599333,-0.057132624,-0.029189892,-0.004462234,-0.023657186,0.06844653,0.033894267,0.011100977,0.0065681157,-0.05904971,-0.041100718,0.15967046,0.052590717,-0.0117278155,0.08878691,0.04652964,-0.01826229,0.028727004,-0.043921836,-0.08447809,-0.11526223,-0.050103318,0.039813578,0.008831831,0.005598763,-0.05568928,0.07958263,0.08359385,0.024547607,0.00020616918,0.04472903,-0.019109074,-0.04332399,-0.030246777,0.03782559,0.047279127,0.049572445,0.02166701,0.01117711,-0.0070355474,-0.073483445,0.027622929,-0.05684022,-0.0025004733,-0.06315086,-0.007825098,-0.026646001,0.12910679,-0.020391406,0.0020901968,-0.020979352,-0.0026978417,0.051187348,0.057846844,-0.047963653,0.03047782,0.08018554,-0.08830693,-0.0063820705,0.0041074,0.021209475,0.06385082,0.10482105,-0.017417032 +3.1.1.64,"This enzyme, which operates in the retinal pigment epithelium (RPE), catalyses the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle [4]. Interaction of the enzyme with the membrane is critical for its enzymic activity [6].",384,1.0,-0.023400543,-0.07647242,-0.053328827,0.02321871,0.03571972,0.06899218,0.021085816,0.0057531325,0.0009988223,0.006032792,-0.0007883888,-0.041058052,-0.085266694,0.018025212,-0.020542769,0.036244284,-0.06261375,0.03465457,-0.004744444,-0.11029364,0.08630759,-0.0660849,-0.007634622,-0.030277314,0.03537049,-0.040275548,0.04842345,-0.040683467,0.014016937,-0.07235328,-0.023854718,-0.07501636,-0.03855798,-0.03141112,-0.015330289,0.094691634,-0.009222002,-0.11755491,-0.04332114,0.020079874,0.01623029,-0.028301282,-0.094700254,-0.003206414,0.07851734,-0.0559915,0.036618512,0.015275475,0.011948042,-0.054654162,-0.052878518,-0.060009275,-0.08352012,-0.027040128,0.031898696,0.1254947,-0.040591396,-0.00060088316,0.095753364,0.04790319,0.06337137,-0.066434056,0.08973094,0.008644914,-0.024452202,-0.09032115,0.03261519,-0.053821612,0.05214446,-0.029157212,-0.04910808,-0.03698875,-0.03098347,-0.07941126,-0.036139026,0.024546713,0.006109422,-0.0068542464,0.020395849,0.0035117115,0.08821116,0.011627341,-0.026024703,0.062329657,0.15886302,-0.004586773,0.007012597,-0.008282755,-0.0019424784,0.07136532,0.0049975542,0.033296905,-0.043756858,-0.042007446,-0.070545875,-0.001880967,-0.027961783,-0.054733332,-0.005141885,-0.03238571,0.011908335,-0.016107844,0.030684216,-0.08378541,-0.083932616,-0.0056650806,-0.025751092,0.119903184,-0.03759873,-0.02849373,-0.0044727144,0.058873445,0.010325283,0.08678043,0.020964744,0.11768783,-0.045710552,-0.08041894,0.08697328,0.056634605,-0.014587876,0.01397178,0.06026515,-0.002962195,0.022793444,-0.0022397905,-0.04028263,-6.573514e-34,0.029897463,0.06991511,-0.049243003,-0.021225134,0.009824813,0.029043728,-0.07693032,0.045586146,-0.08474347,-0.07948195,0.014708625,-0.037450116,0.015016279,0.075159766,0.026725773,-0.07165903,0.026753455,0.05420526,0.024927413,-0.101507165,-0.08816149,0.06910391,-0.047416132,-0.028489271,-0.039296437,0.024392689,-0.04965168,0.03333561,0.07550168,0.016936028,0.020662991,0.015981536,-0.0134181855,0.03065941,0.03360146,0.05493444,0.075814575,-0.03241609,-0.0029502644,0.054491952,0.021107353,0.008444325,-0.041529823,-0.02916105,0.0531845,-0.003723893,-0.07754671,0.12965621,0.004153559,0.01907362,-0.016686803,0.009564998,0.03194449,-0.051886156,-0.07240203,0.010838375,-0.09073087,0.031085216,0.01711405,-0.025754536,-0.0035136845,0.029411266,-0.017170813,0.12230505,0.06477952,-0.0011255261,0.006890616,-0.057832263,-0.08508657,0.041000158,0.002240672,0.031342883,0.089121185,-0.05106802,0.050141484,0.028799286,-0.070778854,0.07827045,-0.0080876015,0.048466593,-0.013050378,0.032059055,0.017249944,-0.06390143,0.021928687,0.0028348619,0.038637538,0.005258869,0.040084198,-0.030303476,0.12926202,-0.108986884,-0.01105055,-0.016056955,0.0042519756,-5.3593106e-34,0.06009214,-0.06607389,0.0681944,-0.050160475,-0.03755477,0.029445047,0.025450222,0.010798493,-0.00012852151,-0.068493806,0.027474685,-0.04859561,0.012391607,-0.02232743,0.016343402,-0.066331856,-0.030385781,0.031450663,-0.039461963,-0.042844683,-0.03145235,0.0016171995,0.084978245,0.060899228,0.02451835,0.06146849,-0.004532273,0.081896946,-0.01780092,0.04365146,-0.042622495,-0.03677298,-0.08014501,0.002704854,0.020783488,0.047138106,-0.027617374,-0.018503498,0.016832901,0.072042175,0.044685397,-0.045332946,-0.0059516765,-0.031913232,0.019022882,0.037458654,0.0091950875,0.039594457,-0.0112989945,-0.08507194,0.0021025403,0.038801715,-0.035796154,-0.056453682,-0.009565314,0.096741356,0.007050181,0.027034909,0.028131602,0.029086938,-0.031607207,-0.069057845,0.020904327,-0.006570762,0.039665107,0.07536212,0.07025679,0.027665826,0.053214796,-0.034265246,0.15223192,0.036940113,-0.054625407,0.083721966,-0.02744509,-0.026357943,-0.011254614,-0.014672589,-0.076456875,-0.0066641946,0.0074011087,-0.062171876,-0.045639478,-0.019121803,0.008378655,-0.057405945,-0.010201383,0.06578113,0.06924551,-0.044170793,-0.04143965,-0.05121703,-0.14761129,0.045373224,0.07358658,-3.6141756e-08,0.04089636,-0.04285384,0.05113974,-0.043075163,0.06755878,-0.021280915,-0.0029894637,-0.005385988,0.005004848,-0.03209072,-0.057212796,0.04062867,0.008646491,0.030486539,0.012522173,0.07800082,-0.019276148,0.017456483,0.025317878,-0.043657947,-0.08104446,-0.07646763,-0.022814007,0.025440257,-0.05228427,-0.02814789,0.013728587,0.09427583,0.0026386103,-0.03485449,0.07934125,0.020036822,0.077838235,0.08411213,-0.07675153,-0.017210668,-0.009105961,0.035864852,-0.06684326,0.060078986,-0.037539456,-0.012287277,0.018727649,0.024361042,-0.06800602,-0.028329752,0.022266412,-0.014522376,0.004441635,-0.005602207,-0.06078261,-0.017784873,-0.048640743,-0.03246189,-0.098443545,-0.08869285,0.03744222,-0.013200624,-0.05536352,0.0031513267,0.011573716,0.06792366,0.13570456,-0.037947625 +3.1.1.66,A highly specific enzyme from Tagetes patula.,384,1.0000001,-0.018301893,-0.052557126,-0.075651884,-0.0149427205,0.008702315,-0.06053644,-0.05568994,0.041940812,0.03937028,-0.0065830955,0.060163923,-0.017781606,-0.08135581,-0.026861912,-0.026121905,0.012326528,-0.022626808,-0.010834182,0.013916964,-0.0037595157,0.052727964,0.027691599,0.02656468,-0.013082741,0.0184485,0.020034106,0.024361739,-0.0419431,-0.027706139,-0.13636854,0.02552371,-0.022611985,0.018541444,-0.06323837,-0.005683141,0.077582,0.0057628336,-0.018825153,0.0980355,0.007826878,0.062033158,-0.06469471,-0.05293763,-0.03923388,-0.07372548,-0.04174809,-0.009183421,0.02327583,0.060367793,-0.02918507,-0.07258948,-0.124403015,0.0060347617,0.013498217,0.016219556,0.051116146,-0.0059027895,-0.13301525,-0.021191316,0.055368144,-0.0028457525,0.0076539284,-0.035329185,0.0043515097,0.02643485,-0.013858629,-0.007994125,-0.03251699,0.023771977,-0.0032973236,0.00094219856,-0.00020978636,0.055861004,0.0042957603,-0.0012026448,0.013452621,-0.06635973,-0.026038067,0.08125092,-0.06268204,-0.014557308,-0.008693214,0.024751337,0.056630738,0.0077874064,-0.055437915,0.057057507,0.031741112,0.036961988,0.016205914,0.038855363,0.019943899,-0.046761796,-0.030892162,-0.052150797,0.029802883,0.05110907,-0.0061780415,-0.04708552,-0.02498094,0.036944978,0.024420923,-0.01416049,-0.105317965,-0.07237973,0.06767847,-0.08138474,0.009323437,0.090069145,-0.020334385,0.01825369,0.025072603,-0.02177191,-0.04583377,-0.06986493,0.014977753,0.07453042,-0.09311286,-0.04260385,0.014772398,-0.051337924,0.003355119,0.008883267,-0.029317066,-0.040165704,0.07601362,-0.10717494,-2.3928844e-33,0.050581556,0.04991896,-0.010325618,-0.055440806,0.023045186,-0.025543699,-0.09627148,-0.009447644,-0.06004013,-0.035646427,-0.014216897,-0.11898212,-0.055782214,0.004655645,0.08518332,0.0429692,0.006321313,-0.024599299,0.021908237,-0.03737971,0.044262707,0.034847535,-0.042400252,0.009883005,0.060131975,0.060735583,-0.032811925,-0.001540976,0.026754146,0.01055927,0.07219657,-0.051169094,-0.049891807,0.02514727,0.08368463,0.037116807,0.00660855,-0.080103,-0.08409852,-0.0030428167,-0.0012151016,-0.019223828,0.039950717,-0.08442072,0.010366632,-0.08853545,0.007476782,0.053920794,0.06882264,0.08820527,0.048554286,-0.01855922,0.09903943,0.00081957894,-0.072563596,0.029100863,-0.02460285,0.021333432,0.06463016,0.016044216,-0.003972863,0.030938229,0.0051000672,0.020033984,-0.008365131,0.033821028,-0.01333189,0.05614001,-0.0131870955,0.09803245,-0.058663376,-0.005110012,-0.021604247,-0.05119704,0.056457046,0.0002122761,-0.052511483,-0.023963174,-0.0068141725,0.032206018,0.015462154,-0.08507189,-0.033920232,0.03829447,-0.061829127,0.0018369408,0.005848443,0.030725824,-0.021052808,0.060900744,0.083301395,0.007602798,-0.07195457,-0.054522272,-0.034043815,8.927981e-34,0.13254873,-0.10726507,0.0641055,-0.0500284,-0.008122272,0.0022165973,-0.0005842795,0.10561466,-0.021600941,-0.05185948,0.027518261,-0.0067910473,-0.01138053,-0.05093765,0.0048394846,0.1218275,-0.021657666,0.10722265,0.027645793,-0.035876572,-0.0028128738,0.09094335,0.00028579854,0.09287463,0.1078819,-0.03013335,0.03406268,0.094437,0.004077801,-0.020080784,0.026257182,0.02507612,-0.015199979,-0.05911717,-0.0459308,-0.0019161688,-0.009903923,0.008822583,0.10741424,0.053784028,-0.03172045,0.012796213,0.040962756,0.054777384,-0.039474994,-0.009357066,-0.056361064,-0.005010705,-0.036463622,-0.057947814,0.051394887,-0.018669348,-0.014699746,-0.033081546,0.019999303,-0.023724359,0.027279276,0.003405797,-0.08051462,-0.07881444,-0.06470695,-0.00487611,0.089831516,0.06393096,0.10383844,0.04128825,-0.056571595,0.03934398,-0.027745888,0.07129678,0.07508732,0.07987622,-0.03222515,0.08074373,0.024885695,0.039783012,-0.04777031,0.022463782,0.011857567,-0.014087,0.05754997,-0.06691306,0.0034862964,-0.07851783,0.004135989,-0.011796017,0.040853783,0.075652726,-0.03100907,0.03223304,-0.02534761,-0.034145962,-0.05040969,0.053208932,0.085866764,-1.6424583e-08,0.010553611,-0.088737026,-0.032661255,-0.041392457,0.0057219863,0.038611516,0.06153482,-0.0047576292,-0.014578381,-0.03052557,-0.020208117,0.11769954,0.05650979,0.032478023,-0.0032775537,-0.03183701,0.035992306,0.028022567,-0.045627143,-0.023608703,-0.08807004,0.018777946,-0.06840965,0.055831805,0.098002166,0.00084383384,0.033105683,0.002557012,0.03060715,0.013398684,0.049191274,0.011685844,-0.04633653,-0.106304936,0.002565599,0.078025505,-0.02998805,-0.10901953,-0.028433714,0.054455254,0.03658439,-0.013113246,-0.09527159,-0.027993571,-0.016993878,-0.0452389,-0.015240714,0.062304463,0.039781846,-0.01766579,0.057354145,0.012280676,-0.05781655,-0.018661678,-0.09037133,0.048491977,0.04256537,-0.07190869,-0.019520564,-0.07939542,0.112264775,0.025599146,0.19720243,-0.012860866 +3.1.1.67,"The reaction, forms ethyl esters from fatty acids and ethanol in the absence of coenzyme A or ATP. Best substrates are unsaturated octadecanoic acids; palmitate, stearate and arachidonate also act, but more slowly.",384,0.99999994,-0.027556008,-0.08652522,-0.0063773785,0.005393175,0.03478619,0.0723513,-0.12947632,-0.004761439,0.0538161,0.0033022845,0.06714044,-0.13501506,-0.1282041,-0.01890439,0.063878424,-0.041272495,0.025371484,0.029265212,0.034869652,-0.039056238,0.12319027,-0.007874764,0.02349763,-0.013220068,0.010659137,0.018736765,0.019667571,-0.0043582437,0.07292796,-0.087145574,-0.002049215,-0.024726957,0.038815252,-0.0507384,-0.0034737957,0.0345541,-0.041857798,-0.06842693,0.05052077,-0.01846845,0.055242017,-0.05494708,-0.017139355,-0.0022960852,-0.02755048,-0.073221914,0.034932908,-0.016418504,-0.04453793,-0.085888274,0.0052071894,-0.046470862,-0.072945245,-0.03561083,0.027094664,-0.074662045,-0.01978656,-0.010776705,-0.03475302,0.035388134,0.077685595,0.024953086,-0.059473593,0.021838369,-0.08386166,-0.014219598,0.03212051,0.033053905,0.083984934,0.0121920435,-0.059770796,-0.08288641,-0.05090897,0.032446876,-0.00096922717,0.0031482251,0.0017299096,-0.11263308,0.0021676559,0.011236733,0.0033457682,-0.024642466,-0.04387802,0.03471274,0.06835936,-0.03474659,-0.03142162,0.007117061,0.01608643,0.02536715,-0.021192217,0.025582772,-0.051158674,-0.036596887,-0.03680093,0.046340093,0.06064656,-0.047431797,0.030057963,0.010482359,0.037180398,0.12662154,-0.061297156,-0.081265524,-0.0566707,0.053695913,-0.042609576,0.0037549473,-0.03755353,0.10319115,-0.0124339545,-0.028930187,0.001534632,-0.007247907,-0.070183545,0.014909014,0.0029121076,-0.101433046,-0.015825227,-0.000610787,-0.07921424,-0.029741246,0.055908673,0.099513486,-0.001853322,-0.007449108,-0.02069405,2.8525027e-33,0.0050007324,-0.025299214,-0.056774624,-0.04076211,-0.0050120307,-0.052421775,-0.04350371,0.018529339,-0.004477726,-0.032953415,-0.009280016,-0.022879474,0.0004573185,0.11501409,0.063578546,-0.038628016,0.02017384,0.08819367,0.074600995,-0.032737557,-0.047701973,0.06181915,0.01383559,-0.040883686,0.015354288,-0.027803445,-0.039459474,-0.017006164,0.03775085,-0.015306457,-0.014006587,-0.045717932,-0.020140909,0.0049599553,0.057620514,0.04986381,-0.07730911,0.011193932,-0.02105032,0.03874065,0.02603838,0.049912564,0.0364385,-0.03148268,0.0434626,-0.002552118,-0.019381722,0.05376336,0.06211746,0.028011918,0.053020917,-0.03405272,0.053400226,-0.0014876666,-0.019798873,0.033527974,-0.03014459,0.018435944,-0.07804192,-0.0038726674,-0.03188611,0.042693418,-0.063851885,0.041368876,-0.045872416,0.0424158,-0.1343044,-0.057715304,-0.033439603,-0.00783703,-0.013415993,-0.020088917,0.060033306,-0.01073846,0.07812251,0.026444955,-0.060489934,0.015429416,-0.0064231604,0.029205931,0.05496119,0.044864345,-0.038664628,-0.0036798858,-0.08290268,0.003632325,-0.029475925,0.01163075,0.07101095,0.0587146,0.01950771,-0.040215015,0.00013018113,0.043638285,0.06537523,-4.35568e-33,0.1214696,-0.06402688,0.070379555,-0.10717242,-0.03573489,0.05391643,0.023308657,-0.0338264,0.02276466,-0.051792793,0.014180018,-0.032176025,0.008917657,-0.04712538,-0.044994216,0.005232242,0.04776116,0.12228711,0.008746629,-0.039928563,0.014672575,0.09681242,0.04686069,0.0585166,0.06790552,0.011926391,0.00653409,0.046182334,0.0017009272,0.026983548,0.03578404,-0.067213215,0.020150492,-0.012692493,-0.010690997,0.11775741,-0.060111083,0.036941327,-0.071560286,0.0480216,0.034241654,0.06555319,0.009043432,0.013066486,0.063805744,-0.04308981,-0.08684564,-0.07269305,0.005907406,-0.052914385,0.04428529,-0.029730782,-0.074358895,-0.02010198,0.07601256,0.068602085,0.0049874703,-0.014845517,0.031876683,-0.08758206,-0.050813977,-0.007944527,-0.013251297,-0.077122435,0.056011513,0.051197518,-0.0354956,0.024837106,-0.01592281,0.019441707,0.116320275,0.09805798,-0.05398123,0.041048422,0.055834066,-0.04107903,-0.026221355,-0.0796802,-0.068924576,-0.029995374,-0.024632603,0.04961862,-0.04748666,-0.015184224,-0.059009142,0.0011656173,0.00048119316,-0.05660764,-0.019432727,0.041980688,0.050255068,0.011264181,0.031169984,0.082307115,0.053304553,-3.5609887e-08,0.03995969,-0.018969964,0.063821994,0.024261793,-0.091685794,0.04554141,0.07079644,-0.06552454,0.033632584,-0.061025854,-0.036924105,0.06813824,0.0920389,0.06473509,0.09235418,-0.013378083,-0.037429098,-0.008421234,-0.053683124,-0.08610116,-0.08819477,0.0060009384,-0.06957733,0.0075059487,-0.033455513,-0.042961575,0.01421303,0.048074316,0.015106988,0.042669166,0.007001956,0.016033687,-0.002824732,0.0065945266,0.05682963,0.023720704,0.036181763,-0.04577359,-0.109064795,0.075519465,-0.0074179806,-0.030869348,-0.08808291,0.01832828,0.10811514,0.01785357,-0.043276604,0.05412725,0.0049765636,0.017014295,0.07391718,-0.022585662,-0.031630024,-0.03321269,-0.0626139,-0.08556108,-0.065801196,-0.01989416,-0.013638054,-0.012183047,0.10479972,0.011683037,0.16544753,0.021899067 +3.1.1.70,"Acts on a number of benzyl esters of substituted phenyl propanoates, and on the benzyl esters of phenylalanine and tyrosine.",384,1.0,-0.06384517,-0.05065062,0.00343979,0.0073598153,0.034256265,0.12503566,0.028248055,-0.015997242,0.06533044,-0.0077748946,0.08790474,-0.027438639,-0.09157715,0.02698034,0.011041407,0.06654329,-0.10385994,0.052397262,-0.039694674,-0.0197775,-0.0088567715,0.020545553,0.0023509783,0.09469624,0.00091644074,-0.06527497,0.037242644,0.04258122,0.031356364,0.018218247,-0.0014769977,-0.03257832,-0.011908008,-0.029973587,0.033325564,-0.03617312,-0.04185751,-0.044195265,0.020908467,0.043028627,0.03671545,-0.1169126,-0.039987236,-0.040153693,0.016569788,0.02228754,0.07076069,0.052172486,-0.013988087,-0.026100263,-0.048578013,-0.02993354,-0.028071519,0.015283853,-0.06449073,-0.015025209,-0.06834193,0.037279658,0.07073203,0.041835103,0.009632584,0.037794776,-0.06960259,-0.0022521652,-0.11922869,-0.0065116794,-0.0074942964,-0.019088319,0.08012255,-0.017131351,-0.02145892,-0.094749354,-0.00049410126,-0.050307192,-0.041453473,-0.014667896,0.0057226145,-0.016350111,-0.011816587,-0.112695925,-0.0032690412,-0.111251935,-0.028023267,-0.0053069233,0.05003604,0.0051045404,-0.04258922,-0.01850524,0.08623641,0.023976339,0.051250555,-0.11423005,0.0077955835,0.0049713952,-0.02346973,-0.035010643,0.032510456,0.0055218795,0.08056181,0.10403383,-0.02276714,0.05996858,-0.037443284,-0.07238993,-0.097579665,0.015062744,0.0017767001,0.023855314,-0.038575362,0.012689473,0.0008164792,-0.044310626,0.0626405,-0.046535973,-0.04704574,-0.018053541,0.007905439,-0.07370675,-0.0029589029,-0.008404801,0.02041091,-0.0036802213,0.093094595,0.07816775,-0.04985543,0.031840283,-0.07038679,2.2348846e-33,0.09235572,0.011996711,0.03754408,0.057990372,-0.013508472,-0.03251754,-0.08484251,-0.009739072,0.0027616601,-0.12656787,-0.018589525,-0.043424666,-0.053509273,-0.0043423795,-0.012271072,-0.0044460613,0.015167448,0.054111794,0.03278426,-0.04485809,-0.012339818,0.09241592,-0.04118861,0.051957976,0.006399695,-0.013062143,-0.06672525,0.039507974,-0.047078766,0.00022426671,0.023119543,-0.07426204,-0.048285596,0.031915125,-0.008141493,0.06353121,-0.083857305,-0.059417643,0.0100610405,0.015507095,-0.032644127,0.02925528,-0.0071850154,0.022716148,-0.02977679,0.040317662,0.025918784,0.14845036,0.023626195,-0.034160316,0.021534272,-0.033006746,0.027796732,0.026030427,0.013098037,0.025251256,-0.039200135,-0.02393881,0.036471907,-0.0021802702,0.017870672,0.034922365,0.0100167105,-0.008669085,0.012705382,0.020737214,-0.079643,0.0050079846,0.010921299,0.022933695,-0.043549247,0.012183616,0.13817406,0.027960187,0.061400875,-0.057441108,-0.067661405,-0.04861334,0.008618067,0.033630338,-0.027148917,-0.08110923,-0.018892016,0.055472285,-0.058773905,0.028886603,-0.041411202,-0.114061736,0.039744522,0.039760202,-0.04650932,-0.09410399,0.0017500918,0.024445739,0.010785702,-4.740115e-33,-0.002166309,-0.003704492,0.0015827861,0.04313477,-0.029573275,0.014951788,-0.018597264,-0.050084274,-0.06309367,-0.058261342,0.05479275,-0.06684569,0.0513987,-0.04401214,-0.09077961,0.02456799,0.09208279,0.07854592,-0.018572452,-0.03655516,-0.039753232,-0.0040396596,0.015716381,0.04809334,0.00858627,0.02037407,-0.047690075,0.05539494,0.010702748,0.124037676,-0.06101481,-0.030046597,-0.013109162,-0.018790612,0.055479307,0.13521527,-0.013602545,0.065128714,0.0115981605,0.027481884,-0.00018399776,-0.0712511,0.048467357,0.071382135,0.0145485345,0.014791312,0.013035208,-0.031678043,-0.06725963,-0.112077475,0.022501068,0.01797961,-0.021470753,-0.047840614,-0.012307613,0.08363957,0.02954366,-0.07141567,0.0074512414,-0.010091711,-0.013051823,-0.09717768,0.010236395,-0.04543819,-0.014005677,-0.06286632,-0.08967775,0.05952542,0.14542916,-0.05800289,0.07903397,-0.04472197,0.09867505,0.04281022,-0.05263283,-0.0884405,0.03525113,-0.11600928,-0.024841085,-0.08413359,-0.025049256,-0.053092185,0.04414531,-0.01332233,-0.07632202,0.058936488,0.018456303,0.0022365022,-0.03641188,0.041510038,-0.0011425264,0.13226266,0.024589788,0.08637201,0.018059004,-2.8098171e-08,0.047934026,-0.07289214,0.09089179,-0.006997444,-0.023759875,-0.002317635,0.04608499,0.011243482,-0.051776227,-0.021908209,-0.013393024,0.07002315,0.028429432,0.0071940804,0.060584158,0.023142638,-0.077823155,0.048326086,-0.07804136,-0.033373926,-0.011886165,0.013553523,-0.043972682,-0.043936778,0.0060581295,-0.058638126,-0.010674746,0.07581361,-0.023025678,0.016145714,0.08938533,0.0027766444,-0.064806394,0.04049584,0.046467833,0.081795186,-0.009809726,-0.04227575,-0.08251095,0.042354777,-0.031221073,-0.026410455,-0.08037066,0.072516546,0.054666176,-0.007572249,-0.010107593,0.03406751,-0.017023806,0.05432513,0.081014544,0.052366424,0.027141202,0.05447472,-0.030378195,-0.009479901,-0.0066795987,0.051706363,0.037756253,-0.03188989,0.03029286,0.062573284,0.08341306,-0.03582791 +3.1.1.71,"Hydrolysis of the acetyl group from the 1-alkyl-2-acetyl and 1-alkyl-3-acetyl substrates occurs at apparently identical rates. The enzyme from Erlich ascites cells is membrane-bound. It differs from lipoprotein lipase (EC 3.1.1.34) since 1,2-diacetyl-sn-glycerols are not substrates. It also differs from EC 3.1.1.47, 1-acetyl-2-alkyl-glycerophosphocholine esterase.",384,1.0,-0.029885972,-0.09189851,-0.06373041,-0.0142396325,0.030087963,0.030311188,-0.04717512,0.024980454,0.041767444,-0.082320854,0.04362066,-0.026098307,-0.09248761,-0.0048212004,-0.049000166,0.007097892,0.04213569,-0.06203769,-0.040226426,-0.048692424,0.13317645,-0.01464183,-0.015702372,-0.026473671,0.09681878,-0.013953101,-0.014386196,-0.02667585,-0.015070714,-0.13628864,-0.0037440695,-0.104095094,0.11197393,-0.014400452,0.081110284,0.06774796,-0.013272388,0.00040768855,-0.018670006,0.017150773,0.06633491,-0.04279445,-0.06817649,-0.019377492,0.0043806443,-0.065624095,-0.022620393,-0.0032532108,0.056953516,0.05008152,-0.0014825569,-0.04301809,-0.07571574,0.013314147,-0.047264077,0.022229867,-0.020739634,0.022439782,-0.09206166,0.028455403,0.02163209,0.024765626,-0.011414305,-0.010366705,-0.07535209,-0.07520617,0.07520691,-0.101280965,0.029963,0.04005958,-0.05922353,-0.09528306,-0.014396073,0.05113351,-0.0032652102,-0.047095124,-0.06699804,-0.019549726,0.019924086,-0.05153714,0.051201057,-0.104333445,-0.016175875,0.06505972,-0.027480565,0.004834558,-0.04680215,-0.037538156,0.039580144,0.018756405,-0.00516225,-0.045636814,0.0017398602,0.029217644,-0.0006002613,-0.0026569762,0.059152603,-0.021038199,0.03241681,-0.010525244,0.0278595,0.07966217,0.0313404,-0.05210762,0.03173923,0.0487035,-0.016491966,0.0019516437,0.005686571,-0.027059264,0.0038306261,-0.017357517,0.09803524,-0.025178421,-0.0031948453,0.04010418,-0.021787899,-0.06619366,-0.0044884756,0.05258237,0.02496383,2.0205265e-05,0.10043719,0.10695148,0.078353055,0.106508605,-0.007015998,3.046311e-33,0.07205013,-0.01657336,-0.0027507332,-0.01368978,-0.07586711,0.01036618,-0.062375803,0.012382103,-0.053262465,-0.012473902,0.008180517,-0.07718554,0.042530265,0.018136125,0.0042025107,0.011586127,0.017503954,0.075866126,0.10638349,-0.06450787,-0.046735484,-0.025908617,-0.09165896,-0.022276392,0.04156496,-0.060101293,-0.013553497,0.017056568,0.06297479,-0.0024798473,0.04874795,-0.015042363,-0.0755942,0.06004632,0.018679846,0.07345353,0.0258175,-0.029196966,0.06978057,-0.0030426022,0.006592126,0.04318302,0.07025863,-0.109199725,-0.0011032602,-0.030841168,-0.11332415,0.047755722,0.07917116,-0.022181086,0.0042187483,-0.020313038,0.13220619,0.09743415,-0.011794764,0.03469919,-0.019352097,0.061414577,0.050234254,0.060072437,0.0024317086,0.104608916,-0.047881212,0.0048184134,0.026582457,0.07946844,-0.061497148,-0.010912289,-0.014808049,0.06044559,-0.040765066,-0.021962773,0.08316059,0.07670841,0.004954849,-0.057294313,-0.043140225,0.08467163,-0.01242407,0.044688597,-0.014506796,0.047162496,-0.0128186615,-0.029797735,-0.10722194,0.04968533,0.011053093,-0.0722939,0.004265948,0.05624903,0.020495737,0.0047851466,-0.06655507,0.0563707,-0.016370015,-3.5596827e-33,0.07145327,-0.11466004,0.0321788,0.0001511781,0.019397745,0.057063174,0.064933985,0.057663534,0.0038441503,0.031007972,0.04263925,0.02865588,-0.034305282,-0.06506434,0.03958417,0.0019296856,-0.049576238,0.046596833,0.07533585,-0.01864541,-0.020313624,0.0050021405,0.041642647,0.13831647,0.0019806435,-0.014761666,-0.0363002,-0.022162205,-0.011548297,0.05282729,0.025432007,-0.0043723253,-0.062871896,-0.03727877,-0.08382207,0.0577319,-0.07184222,0.066619165,-0.058197208,-0.0007144659,0.0068927445,0.029825412,0.039529722,-0.053774208,0.08222685,0.05182923,0.017049292,-0.0012953687,-0.005498114,-0.08897687,-0.05152726,0.003176562,-0.022683231,0.0659335,0.03438852,0.09913951,0.07243964,4.8892347e-05,-0.022193324,-0.06142775,-0.076504976,0.032914832,-0.004066685,-0.03005358,0.05457037,0.042636987,-0.021311454,0.01899592,0.04701496,0.0114631895,0.024425434,-0.0023797639,0.04061299,0.036639858,0.037460763,0.032625962,-0.03904469,-0.037340622,-0.087063186,-0.09212119,0.06300501,0.06206845,-0.024815243,-0.028407343,-0.07628237,-0.03397936,0.016817424,0.052967574,-0.029128889,0.05489256,0.022282222,-0.07152788,-0.1548592,0.003474065,0.044602074,-4.31329e-08,0.06162167,0.030231914,0.085783824,-0.08845865,-0.023565043,0.0015915636,0.087054625,0.038372867,0.07486375,-0.064320706,-0.06782484,0.06526557,0.021034317,-0.019356294,0.023113556,0.020731462,-0.04547975,0.040118475,0.010184335,-0.023429917,-0.0067758653,-0.034509037,-0.05125747,-0.008143355,-0.015865907,-0.011978938,-0.026579274,0.068595834,-0.019415848,-0.009993253,-0.0008353342,0.02388336,-0.013152017,0.012630275,0.069334455,-0.04192151,-0.06869256,-0.05648972,-0.043738913,0.10323234,-0.03331369,-0.06393025,0.005122902,-0.005438087,0.013569021,-0.010188857,0.031582355,-0.023504902,0.046241507,-0.012818872,-0.006880473,-0.039688375,-0.047514465,-0.08218991,-0.039992973,-0.036356095,-0.06066273,-0.05654689,0.025151908,0.005868009,0.006257642,-0.010144655,0.12789449,-0.00263504 +3.1.1.72,"Catalyses the hydrolysis of acetyl groups from polymeric xylan, acetylated xylose, acetylated glucose, alpha-napthyl acetate, p-nitrophenyl acetate but not from triacetylglycerol. Does not act on acetylated mannan or pectin.",384,1.0,-0.005839754,-0.06093389,-0.04136278,-0.05021001,0.03166331,0.030648515,0.023304854,-0.07075221,-0.014416743,-0.009743146,0.071402736,-0.0153019745,-0.11392053,0.018439509,-0.033980746,-0.012755939,-0.099881016,0.027445413,0.014265697,-0.035474792,0.12832934,-0.020961864,0.021841332,0.016583463,0.00611858,-0.021131694,0.017445588,-0.079469554,-0.02601965,-0.09368363,-0.012963888,-0.01693801,0.009596334,-0.02148773,0.11266464,0.09120177,0.02302287,-0.023740277,0.030467726,-0.03211774,0.025023744,-0.11025812,-0.047534008,-0.0507373,0.018740276,-0.09470398,-0.04126495,-0.023179581,-0.048493527,0.027810879,-0.04212842,0.01992643,-0.008380571,-0.015584137,0.054170713,0.0011805871,-0.034594804,-0.061382342,-0.019542018,-0.01208832,0.036337625,0.048966385,-0.03642134,0.0024845412,-0.12070565,-0.077652484,0.043946926,-0.06402845,0.0015629302,0.03868427,-0.039677728,-0.08187826,-0.020547232,-0.023244174,0.0072398353,-0.08547474,-0.008063374,-0.10498658,0.02267657,0.017159145,0.0306625,0.008225955,0.028645433,0.056230973,0.010184131,0.0017251142,0.004958813,-0.003629511,0.009794827,0.04782281,-0.018053798,0.0073651657,0.059053656,-0.01880826,0.036319017,0.0020882473,0.09452095,-0.07419566,0.08274484,0.040139582,0.042031992,0.0446393,0.01286132,-0.12651698,-0.0032106864,0.05411693,-0.041172527,0.05632465,0.09767906,0.045640856,-0.05499889,-0.0065023475,0.034555268,-0.021390578,-0.09994443,0.068256006,-0.02525651,-0.06600849,-0.021804752,-0.053087614,0.0043483954,-0.06404264,0.05942485,0.12651655,-0.014817803,0.07026401,0.0025032824,6.929719e-33,0.035036866,-0.006855637,-0.009992488,-0.06595403,0.024851501,0.0043423125,-0.037855636,0.03242406,-0.015342633,-0.028636526,-0.051043503,-0.020476917,-0.020303546,0.073101446,-0.028812937,-0.0027260084,-0.05138421,0.036750495,0.05548271,0.0049029514,-0.01769113,0.07376861,-0.06849927,0.008939082,0.024515074,0.013144963,-0.047804315,0.03075528,0.022109224,-0.013200162,0.0630435,-0.0493605,0.04867607,0.050068326,0.0064456663,0.054343697,-0.011852438,-0.03357458,0.054652564,0.08455434,0.010613895,0.022221357,0.061556775,-0.07979505,-0.036710482,0.034672722,-0.019345833,0.054111134,-0.013009341,-0.016927995,0.031979162,0.031865176,0.005224684,0.07152336,-0.0074127926,0.028921934,-0.04855104,0.014072527,0.03257429,0.002631148,0.004834596,0.055556327,0.033815905,-0.10776462,-0.048854567,0.029550401,-0.0050680903,0.0016370853,0.06359148,-0.019086095,-0.10720025,0.04140423,0.09148974,0.015605205,0.12156349,-0.02403581,-0.029960344,0.082421914,0.00985583,0.059621528,0.0523582,0.03653302,0.029550357,-0.02109039,-0.068047136,0.026238352,-0.07702669,-0.03956814,0.0034023738,0.03224139,-0.09340491,-0.043477785,-0.06499877,0.057876557,-0.0098243095,-7.861003e-33,0.06142534,-0.096425846,0.039874528,-0.027214138,-0.055357836,-0.01571934,0.04836554,-0.09091912,0.028476138,-0.01886914,0.028934313,-0.02201912,0.041446805,-0.014497645,0.014459442,0.027318958,-0.004213199,0.04450681,-0.049575716,0.007700027,-0.040374406,0.05235954,-0.006233499,0.06930246,0.11875385,0.021993186,-0.039547995,-0.030242532,0.08036339,0.037492182,0.02911773,-0.0655853,-0.026132235,-0.060141895,-0.070259124,0.031058468,-0.11073093,0.1036448,-0.07276648,0.014947462,0.029474508,0.03508535,0.0068303403,0.021517754,0.013567439,0.031548787,-0.014387092,-0.021843128,-0.016324628,0.016854925,0.029783636,0.04528118,-0.008635055,0.019550044,0.05686916,0.11738442,-0.0016389921,-0.008831686,-0.057403624,-0.06107453,-0.07739598,-0.03439972,0.08227661,-0.021310816,0.03422628,0.04808677,-0.049410254,0.036304165,0.04420509,-0.06712564,0.045177225,0.022895837,0.04872883,0.081430845,0.034876864,0.003928515,-0.07114241,-0.113362685,-0.068568565,-0.10274243,0.07788894,0.01399959,-0.025925318,-0.0857563,-0.08661723,0.026802966,0.042229593,0.033430703,-0.010608082,0.021492006,0.010008216,0.036322407,-0.07332504,-0.0029468047,0.020574646,-3.6510773e-08,-0.014436653,0.0049657845,0.054106098,-0.02566881,-0.04966835,0.031549815,0.13744335,-0.0009961874,0.050595455,-0.118806876,-0.037488922,0.11666441,0.013068092,-0.00669345,-0.008182707,-0.037215263,-0.008447015,0.05671263,-0.019420873,-0.035898782,-0.10721145,0.046541013,-0.08825298,0.05657418,-0.07160819,-0.041717824,0.05800165,0.019830493,-0.027778681,-0.024455361,-0.029372478,0.047734715,-0.039796624,-0.0005360294,0.065790266,0.06466,-0.03381293,-0.052311085,-0.027142625,0.005728399,-0.038209148,-0.017422665,-0.0016099438,-0.0016043639,-0.01626753,-0.02259276,-0.027232332,-0.0061884364,0.061207756,0.06391243,0.06729126,0.023150312,-0.05680683,-0.11109016,-0.00024694184,-0.01977399,-0.021510664,-0.038197916,0.028177883,-0.01250358,0.010824912,-0.042106368,0.19192596,-0.019100087 +3.1.1.73,"Catalyses the hydrolysis of the 4-hydroxy-3-methoxycinnamoyl (feruloyl) group from an esterified sugar, which is usually arabinose in ""natural"" substrates. p-Nitrophenol acetate and methyl ferulate are poorer substrates. All microbial ferulate esterases are secreted into the culture medium. They are sometimes called hemicellulase accessory enzymes, since they help xylanases and pectinases to break down plant cell wall hemicellulose.",384,0.99999994,-0.006179911,-0.061003204,-0.07614715,-0.0064826305,0.058235075,0.045938246,-0.0060378094,-0.014752369,0.06980774,-0.04456861,0.028229749,0.00093957386,-0.031412423,-0.0061352407,-0.027036326,0.009191661,-0.07171371,0.050327256,-0.028696492,-0.04498253,0.13927819,0.010896471,-0.008644149,-0.015321285,0.045789372,0.0069307787,0.019804731,0.0005224428,-0.03549981,-0.0873557,0.01288849,-0.008203965,0.12928164,-0.020092173,0.06997876,0.13667357,-0.029598821,-0.056310903,0.0967437,-0.034214985,0.014752419,-0.08169203,-0.021982705,-0.014355142,-0.09796584,-0.030007036,0.057374924,-0.019997986,0.008750525,-0.047658145,-0.07893551,-0.025907638,-0.040858634,-0.00056216895,0.04729165,-0.007335951,0.03693598,0.018610518,-0.028986227,0.040184006,0.009745021,0.010864262,-0.051651258,-0.0035615887,-0.10856062,-0.04202642,0.055227965,-0.045013517,-0.0026019684,0.022620581,-0.060832318,0.0036801726,-0.022797216,-0.016239684,-0.015701398,-0.030253436,-0.016382065,-0.10212281,-0.005878211,-0.0011256622,-0.0031187076,0.03575731,-0.0028360311,0.04615743,0.023611244,-0.040529765,-0.007699502,-0.030215861,0.04200761,0.04045283,0.008592602,0.059424452,-0.009210564,-0.0006252242,-0.033978388,0.0081114285,0.046041764,-0.023055386,0.04420909,-0.033466835,0.013984593,0.027602369,0.0037553203,-0.061364766,-0.07613255,0.041168835,-0.0124057885,0.06819177,0.035750113,0.018462237,-0.0043930686,-0.01853442,0.0002708463,-0.008599081,-0.12509322,0.04938558,0.055184208,-0.11441643,-0.0711629,-0.035747048,-0.02428551,-0.03611209,0.11220434,0.011901702,-0.05652323,0.04217127,-0.095708,4.857788e-33,0.033447444,0.031037472,-0.073337376,0.00013119522,-0.024127038,-0.0065166685,-0.09431232,0.018262895,0.013386364,0.0034562938,-0.060399495,-0.06477753,-0.054917872,0.07175591,-0.008535902,-0.04101254,-0.040088046,0.040880878,0.04784366,0.10094358,0.016937643,0.014156579,-0.019845579,-0.008730593,-0.014039615,0.048574418,0.013876068,-0.001633949,0.09391908,0.0050176536,0.03571787,-0.0736128,0.013078159,-0.022080917,0.0028637105,0.04122561,-0.08959848,0.0037263571,0.028108537,0.05098964,-0.0021833044,0.04377843,0.0787112,-0.08255372,0.031803627,0.030303469,-0.035613153,0.085556656,0.02396522,0.05111036,0.029519377,-0.020778801,0.10293567,0.018658193,0.00019394874,0.030190637,-0.04367411,0.010858741,0.007238382,0.04400559,-0.001925119,0.041737024,0.006151385,0.0039995457,-0.006712898,0.025283115,-0.030276245,0.014362237,0.037623905,0.075692885,-0.06776767,0.026094802,0.04955693,0.07348421,0.04736528,-0.044182826,-0.032202143,-0.004205516,0.10923312,0.016770983,0.055564206,0.013105137,0.019977294,-0.03526181,-0.10763792,0.043472625,-0.06655075,0.0027738395,-0.054543104,0.07380901,0.0036852406,-0.10667534,-0.025359938,0.032823358,-0.021126665,-5.651195e-33,0.11005215,-0.07397973,0.03835274,-0.102008864,-0.057367224,0.019114101,0.02206612,-0.02882128,-0.0019204386,0.0268966,0.02499115,0.027506128,0.019965898,-0.05057994,0.0139793055,-0.012571534,0.03659866,0.075988464,-0.067847595,-0.013050982,-0.05105511,0.11052084,0.008032459,0.011195911,0.08066022,-0.006981013,-0.006169532,0.050844494,0.039208245,0.04400855,0.0047190622,-0.029701358,-0.03881192,-0.046893083,-0.053062636,0.10818857,-0.10876572,0.008535485,0.025967957,-0.0030603528,0.027452292,0.07419544,0.04412374,0.03416889,-0.051075038,0.051758993,-0.10664549,0.011422307,-0.0090246005,-0.01784957,-0.03422699,0.014304553,-0.060679123,-0.011699875,0.01747075,0.0015827506,0.019971792,0.0021158492,-0.10759788,-0.04830826,-0.08912038,-0.02517527,0.08691842,0.02231115,0.012456882,0.06323095,-0.048581805,0.059799373,0.055287756,0.059750304,0.055507503,0.03245515,-0.03169288,0.021277556,0.017877439,0.0041720285,-0.09065412,-0.05305199,-0.09553176,-0.025554089,0.063106224,-0.01590841,-0.05043232,-0.118301295,-0.03194438,-0.08837787,0.023002625,0.07925882,-0.0017475334,0.018253595,-0.029165573,-0.00505336,-0.012031095,0.054174285,0.027645996,-4.265967e-08,-0.06885829,-0.045934178,0.08573356,-0.06808582,-0.061071277,0.020569334,0.0025458175,0.026449248,0.086346254,-0.06869965,-0.025198326,0.07701024,-0.003255837,0.017028471,-0.030600557,0.0013699186,-0.06070656,0.03009856,0.0062943324,-0.0060018734,-0.12436407,0.03082168,-0.1421579,0.07797535,0.027784484,-0.06977104,0.0031014883,-0.009417531,0.013244604,0.02392123,0.076096304,0.0637336,-0.032908745,-0.012224586,-0.00910597,-0.006469685,-0.058419414,-0.024537297,-0.05384817,0.013244011,0.06228732,-0.06669211,-0.09113672,0.012828118,-0.030906932,0.009784689,-0.038522117,0.038610306,0.013741167,0.04983126,0.0856064,0.019335907,-0.036444716,-0.047573224,-0.022987254,0.010067311,0.03937188,-0.016671024,0.05507738,-0.03701399,-0.022514189,-0.029884437,0.23814628,-0.023543661 +3.1.1.74,"Cutin, a polymeric structural component of plant cuticles, is a polymer of hydroxy fatty acids that are usually C16 or C18 and contain up to three hydroxy groups. The enzyme from several fungal sources also hydrolyses the p-nitrophenyl esters of hexadecanoic acid. It is however inactive towards several esters that are substrates for non-specific esterases.",384,1.0,-0.046699718,-0.060995534,-0.0120565705,-0.023456275,0.039487362,0.040389497,0.017794112,-0.011650474,0.018870031,0.029837565,0.0370226,-0.056116927,-0.12626871,0.02206126,-0.03523066,-0.033058118,-0.07854272,0.04199829,-0.04684748,-0.047877822,0.093455285,0.13268086,-0.02278158,0.05490956,0.02787941,-0.05046772,0.031650677,0.02733574,0.02135408,-0.031081965,0.045235127,-0.011404656,0.08807175,0.0006839867,0.026538694,0.08509126,0.019292632,-0.053503204,0.058880392,0.030748215,0.052325148,-0.034912374,0.028837292,-0.040673457,-0.052997656,-0.024041424,0.003271388,0.008949722,0.031430036,-0.03730495,-0.09963317,-0.021396972,-0.029510831,0.0061665713,0.048663903,-0.013884254,-0.006130751,0.04117056,-0.027435027,0.019990344,0.05388341,-0.041405763,0.0041031204,-0.0059685935,-0.03939719,-0.052985102,-0.024620257,-0.012547182,0.021731902,-0.026610974,0.011624052,-0.022690041,-0.018101564,-0.0140337255,-0.06644387,0.042536944,-0.025175652,-0.027720384,-0.04788352,-0.03655869,0.01924128,-0.0020614073,-0.0040185126,0.09577242,-0.05309883,-0.0077931485,-0.000855488,0.023659466,-0.090893775,0.00918711,0.05611014,0.017505579,0.03938678,0.02230241,-0.013719276,0.052336447,0.021465488,-0.083698735,0.059275996,0.050020043,-0.041081063,0.02927594,-0.016684314,-0.094832785,-0.06675114,-0.011948456,-0.07297478,-0.009816293,0.046109617,0.008518457,-0.007268443,0.023891522,-0.053483456,0.0029122212,-0.002104225,-0.06173381,0.084465794,-0.05999842,0.075107835,0.075908475,-0.044042222,0.0022411994,0.029137578,0.08953121,-0.01020413,0.030764919,-0.04760412,3.392706e-33,0.06745027,0.01345618,-0.04947807,-0.06404293,-0.04990632,0.0070086117,-0.0993325,0.04574582,-0.03434057,-0.040535547,-0.094007276,-0.10407416,0.025882408,0.10288686,0.03736408,-0.0752133,0.017259184,0.028825333,0.04045911,0.037598394,-0.056605574,0.06469068,-0.055291254,0.05486106,0.0020346968,-0.00079114933,-0.018561885,-0.1302411,0.033552915,-0.04512879,0.014182352,0.0003582381,0.038526982,0.09518134,-0.005869985,0.08269228,-0.011817126,-0.014895039,-0.035556696,-0.01326538,0.059589617,-0.010451038,0.028525064,-0.018496508,-0.0117250625,-0.07151917,-0.12077115,0.006825457,0.051409867,0.03658047,0.07366864,0.06926321,0.1673297,-0.0135395015,0.011082956,-0.06189004,-0.010632797,0.11254279,0.07518086,-0.05392586,0.039832342,0.022551095,-0.035191182,0.049419217,-0.048948165,0.025442824,-0.06387462,-0.009402438,0.04069474,-0.010059842,-0.07749698,0.019596774,-0.0038505185,0.029776558,0.041672964,0.0155493915,-0.08510869,0.028025199,0.007835269,0.050700586,-0.02419266,0.05544498,-0.021389224,-0.08393592,-0.082881756,0.06415631,-0.034606796,0.029939234,0.026546836,-0.031514738,-0.028296448,-0.12512174,-0.04798513,0.056867734,0.029608252,-5.3644188e-33,-0.024517888,-0.05312937,0.076639056,0.013660567,-0.01168728,0.004760891,-0.08002816,0.019331556,-0.038743045,-0.060541794,0.0944892,-0.044767883,-0.037747618,0.010523284,-0.003447882,0.002672935,0.029844588,0.0135893645,0.023225127,-0.047489785,-0.105415106,0.0077915224,0.048489567,0.08295655,0.0048521683,0.010685948,0.030448314,-0.0476218,0.009471552,0.022589846,-0.028468572,-0.022359155,-0.09903828,0.005774043,-0.042738985,0.0655193,-0.17746301,0.016418314,0.015086032,-0.04786011,0.050343536,-0.0019670762,0.06444933,0.08240631,0.004186988,0.0086996155,0.018579511,0.057675503,-0.027810682,0.044762347,-0.046186857,0.069450356,0.05849467,0.0150465565,0.058136243,0.032213997,-0.022534167,-0.008434193,-0.0395756,-0.0045157666,-0.034256753,-0.06108209,0.008814219,0.062324595,0.05619643,0.024418663,-0.049833644,0.021227198,0.0018568304,-0.026642649,0.092942424,0.056551397,0.12454031,0.11560436,-0.014220543,-0.06592172,-0.04447586,-0.027799824,-0.11877463,0.017840166,-0.0059846123,-0.025256468,-0.06285233,-0.06008916,0.017314857,-0.07733563,-0.027173076,-0.0029508884,-0.03565666,-0.10353078,0.01239139,0.028248044,-0.043458566,0.022158166,-0.028529134,-3.953544e-08,0.09337492,-0.04835422,-0.008559525,-0.073832065,-0.027599078,0.0072547155,0.045010235,-0.016453763,0.007953216,-0.049279284,0.03743332,0.012827972,-0.06270032,0.042986404,-0.037279226,-0.010134117,0.016509194,0.044537514,0.030134968,-0.015589101,-0.0562773,-0.056526676,-0.05568975,0.036009807,-0.052120894,-0.060767867,-0.046082407,0.04641831,0.05978352,-0.0067625013,0.060491934,0.06476251,0.056072272,0.031893034,-0.0071612056,0.10303343,0.01444687,-0.014563388,-0.02835672,0.025878865,0.054299045,-0.11882564,-0.034490563,-0.055111103,-0.04556545,-0.027863197,0.00804491,0.11289044,0.032528937,0.038939368,0.021101475,0.054093067,0.018433241,-0.030651152,-0.03642919,-0.009259813,0.096346036,-0.012198248,0.036229096,-0.028379587,-0.04831727,-0.08154958,0.12403982,0.02987787 +3.1.1.75,Reaction also occurs with esters of other short-chain-length (C1-C5) hydroxyalkanoic acids (HA). There are two types of polymers: native (intracellular) granules are amorphous and have an intact surface layer; denatured (extracellular) granules either have no surface layer or a damaged surface layer and are partially crystalline.,384,1.0,-0.04586089,-0.089769,0.060085803,-0.010048905,0.027076922,0.04835248,-0.0023452416,0.06401843,0.07790733,-0.015712794,0.0011053196,-0.043072887,-0.07252593,-0.022633748,0.02564845,-0.0037763775,-0.035633996,-0.015021322,0.013877836,-0.016751153,0.075993404,0.021832269,-0.071268,0.051629167,0.008657309,-0.047855113,0.04161341,0.008931833,-0.011572877,-0.10150822,-0.05031748,0.010897302,0.030741302,0.010221683,0.0090222135,0.1017357,-0.17744078,-0.068425484,0.010558538,-0.020401992,0.07332293,-0.07352613,-0.03301141,0.006183695,-0.016195854,-0.05625621,0.04088299,-0.0059469426,-0.007464943,-0.0007742306,-0.0400217,0.010435305,-0.05580626,-0.0047418047,-0.038209006,-0.018966928,-0.10889001,0.0048303083,0.08047435,0.009676543,-0.030535659,0.048451893,0.04448815,-0.055032108,-0.025577798,-0.008898701,0.12625685,0.0014797666,0.05199831,0.044061076,-0.055319715,-0.027242092,-0.0051536676,0.012972745,-0.028063277,-0.05914472,-0.016678218,-0.07121645,0.008075599,0.00827604,-0.03793584,0.017665736,0.011484827,0.06673576,-0.012351371,0.06001023,0.02157676,-0.022901434,-0.056561086,-0.040247783,-0.010132239,0.05249785,-0.03652283,-0.019946944,-0.05236035,-0.034091458,0.06746438,0.06929317,0.09489376,-0.029167794,-0.0013296712,0.019083839,0.03918024,-0.103712715,-0.023257611,-0.03658258,-0.036795992,-0.00865871,0.052418575,0.08511647,-0.041735426,0.009371357,0.041945152,-0.02635396,-0.025756283,0.018540893,0.023477288,-0.06475473,-0.06008319,-0.102638595,0.030281417,-0.117574394,0.04774505,-0.019784665,-0.05256208,-0.096213624,-0.05328611,-1.9198334e-34,0.02318314,-0.04175251,0.03538878,0.03592684,-0.06610152,-0.0370467,-0.048804786,-0.07397422,-0.02804614,0.017019562,-0.057900906,0.010144156,-0.03430286,0.080530755,-0.0024086742,-0.037210997,0.03955,0.041548587,0.005614182,-0.031294383,-0.0755439,0.14488232,-0.03399603,0.02946663,-0.022121558,-0.050047986,-0.041366592,-0.022866132,-0.022019563,-0.029076796,0.0116961375,-0.01395036,-0.0014317092,0.09302765,-0.0036219612,0.014386176,-0.09205935,-0.03764332,0.03484579,-0.061219305,-0.025346315,0.05840524,0.062336337,-0.025074478,0.022218017,-0.027996741,-0.029976295,0.08586251,-0.0075857416,0.058364015,0.017582115,0.0033646896,0.116965465,-0.037432406,0.05344091,0.030986665,-0.018513665,-0.047043353,0.0096553145,0.099785015,0.051530145,0.018787649,-0.05247894,0.014494896,0.027154803,0.031515595,-0.09245378,0.08623199,0.060488883,-0.027594756,0.056549504,0.015548441,0.073878035,0.055899438,0.042967264,-0.019858975,-0.10671243,-0.031598367,0.05106619,0.066036046,0.035751674,-0.051248714,-0.033367887,-0.02448124,-0.102390185,0.09688624,0.033761036,0.039596647,0.031618606,0.112892635,-0.057516746,-0.13117065,0.012063824,0.016053684,0.034317914,-2.897089e-33,0.097549856,-0.12303921,-0.01270148,-0.02833504,-0.0040618167,0.036737118,0.08737069,0.023451772,-0.0513142,-0.03903509,0.093186796,0.009165555,-0.016516736,-0.028185518,-0.020381708,0.029397478,-0.020134104,0.037755262,-0.05446957,-0.02651095,0.031488754,-0.050158124,-0.0221184,0.028152207,0.049287803,0.016800364,-0.051061325,0.010086567,-0.024488818,0.06524598,-0.04474818,-0.01233962,-0.038269673,-0.027671527,0.030001909,-0.046631884,0.02963612,0.007460684,-0.050320774,-0.1018608,-0.039425492,-0.0561656,0.10781326,0.07044324,0.0645593,0.0803063,-0.0014447854,-0.049845885,-0.013471798,-0.05771825,7.240047e-05,0.014012744,-0.0018484674,-0.029450702,0.022234865,0.085737064,-0.0026019432,-0.050013315,-0.021912728,-0.062028583,-0.050107934,-0.03669157,0.0051079714,-0.047583897,0.009290825,0.018261043,-0.05774536,-0.03506801,-0.019507801,-0.072590575,0.09087381,0.07272343,0.018734619,-0.04953694,0.0059253313,-0.091519505,0.011322337,-0.030737206,-0.0074460404,-0.03132564,0.043853354,0.042155538,-0.04045468,-0.029603602,-0.045645032,-0.016411446,0.024563769,-0.029168613,0.0040418673,0.016499039,0.0064590615,0.058697317,0.0017708067,0.07368123,0.044398513,-4.489783e-08,0.0067540295,-0.033038117,0.07625506,-0.1117456,0.0093066115,0.07379283,0.018192792,0.042662885,0.04774294,0.0051690415,-0.06453845,0.10246787,0.015819581,0.0056223865,0.032631136,-0.06052488,-0.008011605,0.008479744,-0.011967477,-0.050967302,-0.052280277,-0.004228419,-0.06998915,0.08543241,0.010307151,-0.030791616,0.005342145,-0.03354292,-0.020688163,0.006513042,0.026304107,0.03114608,0.023150261,-0.007854404,0.055448893,0.049750905,0.09137345,-0.036076397,-0.06990859,0.0031309517,-0.009845653,-0.040909898,-0.024555631,-0.017274518,0.11790073,0.007779072,-0.08559129,0.018270524,0.016054139,0.025796026,0.07337413,-0.005362183,-0.06946255,0.015209343,-0.012909578,-0.034716263,0.051104464,-0.011309144,0.08609081,0.046537805,0.05409105,-0.010111586,0.20304142,0.009982653 +3.1.1.76,"The main product after prolonged incubation is the dimer [3]. Besides hydrolysing polymers of 3-hydroxyoctanoic acid, the enzyme also hydrolyses other polymers derived from medium-chain-length (C6-C12) hydroxyalkanoic acids and copolymers of mixtures of these. It also hydrolyses p-nitrophenyl esters of fatty acids. Polymers of short-chain-length hydroxyalkanoic acids such as poly[(R)-3-hydroxybutanoic acid] and poly[(R)-3-hydroxypentanoic acid] are not hydrolysed.",384,0.99999994,-0.018369198,-0.08551231,-0.03899976,-0.033149928,0.042028304,0.020849189,-0.092301436,0.054736014,0.0153693175,-0.10531793,-0.02991231,0.033719003,-0.057638288,0.054630503,-0.04574367,0.009806542,-0.019285895,0.022212625,-0.02809365,-0.040130764,0.05861134,0.004766414,0.020711899,0.043042306,0.023539253,0.011186588,0.09705444,-0.07138463,0.0835787,-0.034102388,-0.023271065,-0.010797875,0.048035696,-0.1211301,0.020168541,0.13766086,-0.054639753,-0.044563096,-0.018091602,0.05846469,0.12396006,-0.052389976,-0.024466194,-0.03741448,0.0077752112,-0.024851626,-0.038988095,-0.010494621,0.0047422065,0.038008362,-0.024770923,-0.058252335,-0.019347101,0.0049637742,-0.012768953,-0.069142334,-0.039188847,-0.014996537,-0.05942475,0.054656304,-0.014888604,0.044186242,0.049676124,0.02116349,-0.029032538,0.008726123,0.07245729,-0.03918568,0.0743452,0.039211504,-0.10529991,0.0036187235,0.020715619,-0.013727183,-0.063112214,0.021687798,0.028273376,-0.08932614,0.022895867,-0.022643033,0.01889244,-0.053237997,-0.058007058,0.10570161,-0.0132823195,0.056639154,0.021509666,0.024901956,-0.043373883,0.0307761,-0.010879196,0.06684633,-0.07082871,-0.025007246,-0.04650649,-0.006013577,-0.016695827,-0.018290667,0.0076531614,-0.044389006,-0.022523744,0.03579146,0.014516411,-0.08209487,-0.08225149,-0.0068040458,-0.074068606,0.011058577,0.10789359,0.09921095,-0.05397926,0.020516438,0.050290853,0.060684934,-0.035741907,0.07370252,-0.0018705003,-0.037946254,0.023246337,-0.025102101,0.073944114,-0.096635595,0.14420559,-0.07299399,-0.043355387,-0.0052190516,0.030844664,3.527198e-33,-0.01071649,-0.040694192,0.0019458208,0.039002508,-0.02031823,0.03258023,-0.0729277,0.019826677,-0.03596793,-0.013691877,0.0026454278,0.023844585,0.009589568,0.06672021,-0.005493733,-0.024170496,0.09801436,0.04409119,0.05062081,-0.02037997,0.0061660716,0.07295956,-0.07568683,0.04623894,0.028071124,-0.030978324,0.003947048,0.046233635,-0.0133408345,-0.044769242,0.06958412,-0.04153683,-0.04275656,0.047164347,0.0036098014,0.014152823,-0.03659865,-0.04611379,0.01101849,0.0790037,0.043746106,-0.0015114057,0.09669752,-0.06268432,-0.039216682,-0.024808725,-0.02248745,0.10513574,-0.024247276,-0.009642886,0.037192494,0.04707722,0.025753248,-0.068006605,-0.05880319,0.011060278,-0.059224192,-0.0035416826,0.01854444,0.024495808,-0.09560758,0.08755228,-0.011187521,0.007649683,-0.039586134,-0.054385144,-0.04094424,0.037218872,-0.010671528,0.035915323,-0.0015467379,-0.046823334,0.030630752,0.045204956,0.038368244,-0.04167653,-0.045286078,0.012284352,0.0068196612,0.029704642,0.07757041,-0.015465847,0.004227267,-0.016072001,-0.027280755,-0.008045213,-0.013115009,0.04764495,0.003973873,0.055529285,-0.011687363,-0.1021842,0.018371254,0.04747286,0.010254409,-5.7513934e-33,0.074363805,-0.10352222,-0.026525622,-0.057339277,0.0036303382,0.037373852,0.09761949,0.022662118,-0.035315573,-0.11241539,0.053110633,0.020614395,-0.017787827,-0.025471594,0.030529637,0.0690854,0.0012316268,0.04859354,-0.035041865,-0.054997787,0.053800695,-0.0035214392,-0.067340896,0.04412083,0.027591618,0.04940838,-0.005490608,-0.00012816604,0.0058156205,0.052196883,-0.009179109,-0.042352296,-0.06582318,0.010655096,-0.04451678,0.023782743,-0.041177448,-0.08438853,0.018937774,-0.0041387095,0.030813111,0.049097043,0.026203824,-0.0020738225,0.035932574,0.031551886,-0.036504444,-0.09620306,0.06138103,-0.012570253,-0.009330288,0.023243528,-0.0027872964,0.03619183,0.028881744,0.03980245,-0.014220322,-0.06741464,0.013555455,-0.044573497,-0.049432587,-0.08710786,0.040866848,-0.019325934,-0.059979346,0.03417498,0.012178883,0.050911438,-0.009218581,-0.08639068,0.10925443,0.04453185,0.0032276718,0.06757779,-0.06074114,-0.06591717,-0.03172529,-0.015082077,-0.011454379,-0.08880844,0.07311229,-0.0054853284,-0.067343935,-0.06325731,-0.025482472,-0.07061717,0.06907714,0.030239716,0.013825411,-0.0007221759,-0.0019040582,0.06176986,-0.07326101,0.053902514,0.060654446,-4.569915e-08,-0.013692173,-0.1183998,0.08100091,-0.018164253,-0.038760457,0.02103371,0.06651745,0.032614227,-0.02373517,-0.022170208,-0.025978478,0.04349459,-0.06326224,0.065022595,-0.010598825,-0.033131767,-0.04418625,0.02287081,-0.0068947324,-0.050196875,-0.12945957,0.028835677,-0.05688178,-0.024399357,-0.017374258,-0.0063231047,0.11523207,0.01929497,0.004755211,0.0068264953,-0.068717055,0.047502067,0.015569528,-0.015675507,-0.010396393,0.021995258,0.08411992,0.019438453,-0.090628535,0.01722676,-0.0117065925,-0.06508706,-0.040451404,0.012806112,0.124197826,-0.05796316,-0.057056878,0.0719167,-0.050472174,0.018515429,0.06551823,-0.033799563,-0.037715245,-0.02746112,-0.01723401,-0.017703567,-0.023943987,-0.08336477,-0.013586743,-0.004239793,-0.017405514,-0.009100207,0.2648143,-0.01736228 +3.1.1.77,"The substrate is lipid A on the reducing end of the toxic lipopolysaccharide (LPS) of Salmonella typhimurium and related organisms. It consists of diglucosamine, beta-D-GlcN-(1-> 6)-D-GlcN, attached by glycosylation on O-6 of its non-reducing residue, phosphorylated on O-4 of this residue and on O-1 of its potentially reducing residue. Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3. The enzyme from human leucocytes detoxifies the lipid by hydrolysing the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the disaccharide (LPS). It also possesses a wide range of phospholipase and acyltransferase activities [e.g. EC 3.1.1.4 (phospholipase A2), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.32 (phospholipase A1) and EC 3.1.1.52 (phosphatidylinositol deacylase)], hydrolysing diacylglycerol and phosphatidyl compounds, but not triacylglycerols. It has a preference for saturated C12-C16 acyl groups.",384,0.99999994,-0.07278327,-0.09890198,-0.090164244,-0.011095381,0.050049074,0.055152062,0.015721507,0.07975652,0.07892705,-0.026878351,0.017533572,0.02198384,-0.049973745,0.047167398,-0.043409932,-0.005046568,-0.04281138,0.020350944,-0.08369417,-0.07577034,0.080857016,0.011289625,-0.004096067,-0.0272028,-0.0020126135,-0.010766933,0.040963795,-0.022444826,-0.005251541,-0.03585441,-0.0062936237,-0.048855152,0.10130932,-0.080025755,0.062307797,0.07107413,0.041214842,0.00643353,0.07874101,0.022922862,0.0269858,-0.012621198,0.003530864,0.00035263563,-0.032265086,-0.01428528,-0.031736508,0.05651102,0.043762255,0.061451364,-0.009347582,-0.024980782,-0.009322564,0.050478514,-0.0010033909,-0.009038224,-0.055045847,-0.057525165,-0.048148427,0.023979403,-0.032636568,3.0296615e-05,0.043227214,0.046797063,-0.060365524,-0.04167286,0.03868358,-0.080885,0.0077576847,-0.02785127,-0.072105765,-0.030505747,-0.012119178,0.00227051,0.021223614,0.036092307,0.06149245,-0.06912044,0.024969269,-0.068035,0.040375218,0.027396051,0.060834527,0.15995575,0.007457946,-0.078893185,-0.057138175,0.009551071,0.030402295,0.05072353,0.028380774,-0.027642312,0.04981083,-0.019617137,-0.010261489,0.027440771,0.025526071,-0.034423187,0.030774113,0.018615616,-0.064111546,-0.012555165,-0.03790627,-0.12348885,-0.02990695,0.036037568,0.019834856,0.04937864,-0.010758615,-0.02244072,0.009558749,0.021049405,0.023017514,0.016376358,-0.037535425,-0.0036514113,0.029064259,-0.087686606,-0.05959099,-0.03320727,-0.028953768,-0.073563084,0.05531694,0.04660261,-0.007921985,0.05385668,0.0053833444,5.543853e-33,0.010366924,0.011221748,-0.023701008,-0.010746615,0.035089657,-0.040350445,0.013988426,-0.00072319905,-0.0044751656,0.054142635,-0.043976367,-0.09991666,-0.008367779,0.09322488,0.013399372,0.04363431,-0.008766306,0.0078406455,0.050973166,0.040258,0.055799056,0.005911335,0.052730277,-0.0683255,0.057193745,0.059590437,-0.08442541,0.021837866,0.01836005,-0.002982182,0.01735525,-0.04263466,-0.08841457,0.060386468,0.060618736,0.025618501,-0.08421143,0.011725878,-0.06517436,0.05594056,-0.015328315,0.03904446,-0.062893815,-0.046353184,0.053461187,-0.048677452,-0.07534405,0.04703827,0.009180155,0.0476541,0.061976302,0.013292694,0.11645182,-0.020740587,-0.009098828,-0.04346628,-0.02332369,0.0009371665,0.04838323,0.0011278775,0.0018050955,0.06460949,-0.07248729,-0.0025035792,0.031662345,0.018252434,-0.05791039,-0.07698453,-0.043846574,0.001192969,0.058277123,-0.039218795,-0.042852126,0.06391804,-0.010875266,-0.038394682,-0.025018305,0.066699676,0.043970603,0.01816225,0.027631426,0.023200057,0.04111554,-0.052323863,-0.11130988,0.042301547,0.00028124757,-0.06516414,0.03644239,-0.039223615,-0.013132365,-0.04794696,-0.03389207,0.034580976,-0.030073842,-6.1236893e-33,0.052724123,-0.08774316,0.016011912,-0.121863075,-0.06931955,0.01879458,0.024421705,0.08716309,0.10528691,0.005224952,0.049163647,0.016345887,-0.03700328,-0.011422082,0.050037976,0.027205108,0.0008710606,0.09807656,-0.03650233,-0.04604735,-0.0049616336,0.058210865,-0.0101948,0.0894558,0.047550157,0.02002139,-0.031912237,0.03777296,0.019670393,0.060324132,-0.02395481,0.04160584,-0.011391609,-0.060283914,0.004305852,0.012930641,-0.07510593,-0.0040128757,-0.013511928,0.04818246,0.05150823,0.037748817,0.07803049,0.015064759,0.035501808,0.109036684,-0.1246532,-0.0055756504,-0.054281216,-0.04269244,-0.015661187,-0.053439513,0.05305378,0.0602826,0.12135767,0.09100145,0.06966319,-0.011766009,0.02472794,-0.16088383,-0.04328465,-0.030788353,-0.039728742,0.05341215,0.06408574,0.06439214,-0.042503614,0.0206228,-0.034265444,0.007933529,-0.05677979,0.02098222,-0.021777911,-0.06418448,-0.043709908,-0.039166518,-0.09602251,-0.03820782,0.035708655,0.006485681,0.0367024,-0.041308515,-0.040921375,-0.04809167,-0.009982741,-0.029152507,0.03395066,0.13221955,-0.00482367,0.05587809,3.3147764e-05,-0.07178827,-0.05739353,0.08460735,0.104708426,-5.820201e-08,0.06424587,-0.03203288,0.0018398627,-0.079085276,-0.07839159,-0.016130598,0.013521914,0.04397277,0.07840673,-0.06385479,-0.009846257,0.14486545,0.052771572,-0.018865673,-0.048024494,0.03831945,-0.040977303,-0.036404774,0.0021636256,-0.04933502,-0.025480999,-0.022024972,-0.031062862,0.011034337,0.04695554,-0.070333645,0.044761926,-0.016561612,-0.032750737,-0.04034107,-0.053235933,0.043530904,-0.08340552,-0.025945935,0.025365084,-0.011395414,-0.02743433,-0.09458828,-0.014953691,0.073149435,0.01019861,0.008358513,-0.08741508,-0.012347323,0.049491215,-0.005508507,-0.026826607,0.040591996,-0.06352868,-0.033055566,0.01572744,-0.030274725,-0.04316343,-0.036954354,-0.12035154,-0.036584865,-0.028435944,-0.025663571,-0.010268088,-0.04228128,-0.0064203897,0.059087448,0.1855178,-0.020691402 +3.1.1.78,Following hydrolysis of this indole alkaloid ester the carboxylic acid decarboxylates spontaneously giving the sarpagan skeleton. The enzyme also acts on akuammidine aldehyde (the 16-epimer of polyneuridine aldehyde).,384,0.99999994,-0.039105963,-0.028395662,-0.054606996,-0.04617274,-0.030557828,-0.0009799222,-0.067873985,-0.013025195,0.046843078,0.0012953845,-0.000105115134,-0.027283894,-0.055062383,0.0048607583,-0.043455742,0.043772526,-0.12967317,0.07150697,0.013286445,0.0073968684,-0.023445887,0.028075226,0.04306688,0.006885848,0.10937736,0.047864895,0.023105182,-0.018290536,-0.033167187,-0.012890987,0.07824451,-0.026956128,-0.017922591,0.0035947724,0.019342419,0.06377251,-0.096282,0.030008467,0.10177904,0.034729417,-0.017328452,-0.051024698,-0.054610323,-0.0483658,-0.011587006,-0.056927193,-0.07793948,-0.01909956,0.007148481,-0.017680636,-0.025807936,-0.0015520392,-0.05242982,0.042785715,0.050672296,-0.052249067,-0.051072333,-0.008609387,-0.045908105,0.08206827,0.010180181,0.041209742,-0.03662197,-0.04981592,0.0074928836,-0.055875476,0.016639484,-0.039898228,0.085693896,-0.010142985,0.0021569075,-0.057022545,0.0095980335,0.01876709,-0.099801265,-0.034185354,-0.02544775,0.02532917,0.06828224,-0.042548377,0.037077162,0.02716931,0.08900173,0.051517434,-0.03673812,0.01870726,0.056733895,0.04717495,0.048043717,0.06219536,0.06824221,0.010701548,-0.079270184,0.028485209,0.032885455,-0.041764874,0.05057364,0.060896788,0.011724995,-0.009060139,0.045672055,-0.008716812,-0.06141801,-0.09158592,-0.026333634,-0.05255454,-0.004892603,-0.041350283,0.013471876,0.021087697,0.017380295,-0.039373916,-0.042893913,-0.0020535998,-0.018643023,0.073815405,-0.06827415,-0.065871075,-0.119800515,0.03188582,-0.06460033,-0.00062847807,0.0073182546,0.056239657,-0.03668175,0.046420354,-0.04785241,4.4828733e-33,0.07286848,0.031048488,0.030994799,-0.07566784,0.07972307,-0.05626513,-0.10449896,0.03110221,-0.040475037,-0.049545094,-0.060646746,-0.05083022,-0.082211815,-0.0042021223,0.009925259,0.011428276,-0.10595917,-0.022916231,0.016997585,-0.073915444,0.0016995702,0.06292545,-0.090373844,0.050330754,-0.021173203,0.03251157,-0.059314486,0.017067568,0.016265038,-0.01205337,0.0026379928,-0.07777585,-0.065441266,0.022016585,-0.064760536,-0.00724472,-0.05653407,0.016689997,-0.081113435,0.10556664,0.10417689,0.0058191624,0.018060548,-0.001759476,0.025479792,-0.031921398,0.00912597,0.10550845,0.017394127,0.056992408,0.023105264,0.04548881,0.03044023,0.044791725,-0.025485909,0.038491998,0.0056101764,-0.06351848,0.047881722,0.039015386,0.011981708,-0.058177635,0.067258954,-0.04060534,-0.02728403,-0.012008318,-0.007954825,-0.05232786,-0.015206228,0.070272915,-0.036058735,-0.04468677,0.08786157,0.0019434516,-0.02346781,0.031458132,-0.041128814,0.038675424,-0.04604427,-0.019103905,-0.049265396,0.027682599,0.0640878,0.047361363,-0.08393939,0.025477257,0.006358677,-0.040575497,-0.029861948,0.08133221,0.0005405896,-0.024527827,-0.064602956,0.025502115,0.021455081,-6.465435e-33,0.14469936,-0.08529786,0.0009116141,-0.056816395,-0.050415732,0.063699834,-0.03130506,0.03608785,0.051830884,0.04669195,0.014178649,0.0018253953,0.100077815,0.0474636,0.015561069,-0.020878982,0.094578125,0.1808099,-0.026569791,-0.008807904,0.007852186,0.113276705,-0.048101075,0.042640988,0.0015515886,-0.008287117,0.08176234,-0.014231179,-0.033723217,0.020158445,0.04121433,-0.013942476,-0.05815087,-0.024635822,-0.00632622,0.0997102,-0.015525188,-0.016955514,-0.06361254,0.048475772,-0.0050410163,0.051296894,0.019087592,0.10647465,0.059852928,-0.06511223,0.016965851,0.04883218,-0.02926264,-0.085448876,0.06261175,-0.021610945,0.0266031,-0.051913492,0.005519534,0.08106016,-0.029333318,-0.07314367,-0.0039601936,-0.020169014,-0.03979989,-0.059497595,-0.0051140427,-0.06003611,-0.02038773,0.025583277,0.011344992,-0.00053254334,0.079227395,-0.069958895,0.07651539,-0.03497628,-0.041382346,0.1393545,-0.023196777,-0.01032709,-0.008722021,-0.05186784,0.030496266,-0.097008765,-0.0029114138,-0.032754455,0.020982971,-0.109531075,-0.012597957,0.007458728,0.0165885,0.09618057,-0.05109475,0.021240607,0.06665639,-0.005579038,-0.039431717,0.09809447,-0.0024248525,-3.3815056e-08,0.05751933,-0.035634015,0.0049902345,0.0391261,0.010244734,0.035806503,0.11659047,0.050490525,0.009447631,-0.06950425,-0.002755272,0.018381799,-0.021230562,0.08976507,0.02356158,-0.017573208,-0.037167586,0.08034229,-0.08424906,-0.0705698,-0.085005246,-0.009427238,0.02738628,-0.031300336,-0.039443817,-0.009428078,0.04776413,0.05655807,-0.0031134202,0.021345433,-0.014085788,0.06465412,-0.036334325,-0.051571965,-0.032539986,0.0391211,0.06513774,-0.03762767,0.0016768543,0.03156368,0.006655073,-0.10807081,-0.02770976,-0.0027340525,0.0038129457,0.015364809,-0.03628212,-0.04166485,0.047851995,-0.028289944,0.113669075,0.024810728,0.02859192,-0.044776537,-0.06617731,0.024842052,-0.08573492,-0.020339044,0.050158925,-0.07233352,-0.015121224,-0.007796928,0.103691325,-0.0265477 +3.1.1.79,"This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) [2,3,4] as well as cholesteryl esters [2,4], steroid fatty acid esters [5], retinyl esters [6] and p-nitrophenyl esters [4,7]. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond [8]. The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.",384,0.99999994,-0.018599156,-0.12476352,-0.07762808,0.008262641,0.009961993,0.034457643,-0.051854886,0.034324467,0.035313316,-0.062701404,-0.029959856,-0.020998688,-0.08665333,0.043354683,0.027729057,0.008673911,0.0055936594,-0.049285658,0.03477225,-0.086366095,0.124311276,-0.035221413,0.011464845,0.034692336,-0.05175488,-0.033805013,0.050043356,0.008283632,-0.07824036,-0.0442835,0.029121079,-0.09027139,0.02546478,-0.03383663,0.01950618,0.06044125,-0.037460964,-0.014961721,-0.019793712,0.037174895,0.057749283,-0.074635,-0.086527385,0.004201777,0.018061899,-0.064094685,-0.048439734,-0.0141973635,0.00815682,0.05331449,-0.054067384,-0.08944781,-0.015646162,-0.018726535,0.0012116884,0.028025474,-0.05804831,-0.0003436812,-0.034036268,0.040244315,-0.010517186,0.0098413015,0.033236105,-0.011092792,-0.037977256,-0.047852464,0.033829384,-0.080887675,0.05483171,-0.09157186,-0.04094726,-0.08018504,-0.011235071,0.01082956,-0.0486869,-0.04855305,-0.03947039,-0.0132125225,0.06174302,-0.059558276,0.043237913,-0.020555407,-0.013709387,0.1505729,0.04204201,-0.038171355,0.03110626,-0.02127104,0.043806616,0.07476084,0.040678293,-0.030143084,-0.06816961,0.03027451,-0.037992187,0.004827407,-0.05169472,0.0016574498,-0.045739274,-0.043324586,0.04027084,0.029784864,-0.01708549,-0.08023302,-0.065030366,0.039154388,0.01206538,0.036358535,0.027706712,0.031262543,-0.031824615,0.006582369,0.06356662,0.024433566,-0.0019973349,0.086171076,-0.07834476,-0.0031421133,0.011118481,0.045246754,0.023954626,-0.01645405,0.121940255,0.07109675,0.039849866,0.092899635,-0.044228,3.402623e-33,0.02084485,0.01027814,-0.024304101,-0.0124445995,-0.021040307,-0.018961886,-0.0816165,0.06758557,-0.09072311,-0.047739014,0.027379205,-0.037163008,0.014882889,0.038400352,0.026573557,-0.04079121,0.041542225,0.07139852,0.1270572,0.005217113,-0.05307485,0.07564481,-0.004771032,0.010583441,0.023388797,0.0010313899,-0.026303004,0.06457317,0.020158883,0.0069308565,0.0125496425,-0.12616313,0.053708166,-0.010859286,0.0906328,0.029470166,-0.012048614,0.0031359047,-0.04567218,0.05226129,-0.007149675,-0.042276587,0.06237757,-0.051550776,0.006491743,-0.035085343,-0.08085473,0.097562425,0.055646054,-0.0066812416,0.036951896,-0.017280115,0.11489613,0.071745254,-0.061248276,0.05612298,-0.059431788,0.048215307,0.039621368,-0.034396164,-0.007875106,0.060352284,-0.036740728,-0.020127624,-0.02065336,0.019632949,-0.066591576,-0.03110845,-0.016162941,0.12813695,-0.013377593,0.038178504,0.0621039,0.018295169,0.08491325,-0.0428066,0.02218821,0.08631681,0.0135393,0.0014130576,-0.020120228,-0.020168068,0.018679028,0.012472558,-0.076865785,-0.001221134,-0.028014103,-0.02059335,0.026778094,0.07209511,0.0013396846,-0.053587377,-0.040302068,0.08205115,0.0130991405,-4.3077295e-33,0.045928154,-0.09049298,0.06577106,-0.09667081,-0.031267073,0.08809838,0.05934706,-0.033986364,0.046942696,-0.04298077,0.05170988,-0.039006766,0.00017433049,-0.082507335,0.010126909,0.062052798,-0.0550271,0.011524001,0.005179951,-0.08160523,0.010584608,0.081263654,-0.0133042205,0.10175551,0.05356024,0.01250335,-0.05951135,0.07388823,0.043503277,0.07348922,0.021670908,-0.030206176,-0.02491178,-0.069366135,-0.018904272,0.059415884,-0.060388383,-0.010826524,-0.04039563,0.033023972,-0.045625724,0.051362135,0.07828234,-0.012484082,0.059329372,0.07147382,-0.00035707737,-0.026478799,-0.017495634,-0.041573238,-0.022457246,-0.021020446,-0.04638634,0.03941714,0.043941,0.071142785,-0.02995508,-0.012045908,-0.00046698286,-0.0846299,-0.037538484,-0.05058897,0.010202283,0.051108964,-0.014447512,0.017313756,-0.019387048,-0.04469609,0.01597071,0.013962415,0.028926594,-0.012585618,-0.015941596,0.08594236,-0.046313,-0.021952223,-0.0131477425,-0.037285093,-0.048658427,-0.055472005,0.008984079,0.005836094,-0.036567133,-0.11575162,-0.07126136,-0.0009809849,0.03006955,0.10000241,0.018950542,0.040202033,-0.022378597,-0.033823498,-0.15563963,-0.032936044,0.015367368,-4.8619704e-08,0.0244777,-0.10230387,0.049748413,-0.054665066,-0.0051512467,-0.0062244046,0.07258434,-0.029985346,0.031747688,-0.11047281,0.006188784,0.09956961,-0.02501254,0.026692431,0.008668805,0.005204707,-0.015457655,0.037555464,0.010969594,-0.048088938,-0.029592095,-0.030852191,-0.07853972,0.0028093397,-0.015562045,-0.03792787,-0.012971316,0.09499946,-0.026193023,0.0068283835,-0.0017188509,0.015095276,0.024017334,-0.006648267,0.058731034,0.09425333,-0.030793915,0.007672959,-0.053940456,0.14562199,0.013778982,-0.061951846,-0.013772457,0.019489756,0.06461258,-0.024503266,0.038922988,-0.01032119,0.031948846,0.003524623,-0.022515804,0.013360561,-0.038889956,-0.014886639,-0.0383129,0.004865312,-0.044296503,-0.101151645,-0.03062572,-0.040416222,0.045587014,-0.0011107172,0.20239124,-0.03374247 +3.1.2.2,Also hydrolyses CoA thioesters of other long-chain fatty acids.,384,0.99999994,-0.052041534,-0.06643715,-0.015700132,0.006004623,0.071946874,0.025390457,-0.12892538,0.05170964,-0.011395565,-0.058059186,-0.002443619,-0.06400094,-0.042632077,-0.04630348,0.029102808,-0.012401567,0.026538698,0.010223364,-0.006951297,-0.06181148,0.046447385,0.06987573,-0.04480007,0.043915078,-0.020475686,-0.003989935,0.06829459,-0.019575546,0.012453852,-0.07433363,0.012369221,-0.020498274,0.05803927,-0.044342667,-0.00465311,0.09690468,-0.036968596,-0.04106182,0.044683345,-0.017070225,0.09273753,-0.05521127,0.044358592,-0.023209369,-0.07525394,-0.071954556,0.008803452,0.009260087,0.034188025,0.08110882,-0.033220086,-0.048413616,-0.067381196,0.05979096,-0.036951628,-0.03357147,-0.032721408,0.03226365,-0.06350226,0.057867885,0.01593832,0.025581699,-0.02049605,0.040144425,-0.03413644,-0.008939757,0.0073414757,0.044298425,0.048143122,-0.010492229,0.00021259449,-0.0043030255,-0.02479245,0.068308376,-0.038377956,0.053155564,-0.016359625,-0.09325608,0.051850304,-0.053432234,-0.04739814,0.06483058,0.033391085,0.08739304,0.016275162,-0.0066328314,-0.019842142,-0.0320221,-0.06839253,-0.00079398695,0.09509655,-0.03830263,0.0053669126,0.010154573,-0.06597939,0.043456912,0.036438,-0.031654157,0.010760388,-0.056980126,-0.026183605,0.041621063,-0.0032787507,-0.042123817,-0.064543724,0.034604337,-0.030273585,0.033993207,0.01965124,-0.01352612,-0.013942655,-0.0073057674,0.035935424,0.008132958,-0.043144215,-0.02432985,0.035883877,-0.03050411,-0.030783448,0.0059919506,-0.016560841,-0.049256433,0.08818785,0.032998193,-0.03339414,-0.057609074,-0.0040792753,7.817277e-35,0.016483922,-0.019488154,0.050807253,-0.037656613,0.027325967,-0.04375926,-0.082807705,0.041172832,-0.020429961,0.037967302,0.02538887,0.009357034,0.0045662904,0.05770978,0.029335348,-0.100703895,0.02592803,0.04975138,0.06699204,-0.0049069296,-0.046574213,0.05469723,0.011228576,-0.028742075,-0.00093034375,-0.02548622,0.019431205,0.058233228,0.07575527,0.019251069,-0.0015734448,-0.06507275,-0.010891053,0.029458582,-0.03327174,0.02556093,-0.09241772,-0.019063596,-0.03636498,0.112300396,0.09317936,-0.037122186,-0.020590287,-0.062012155,-0.04619057,-0.038477667,-0.019213602,0.06250039,0.0037134765,-0.0031877249,0.07132112,-0.05921608,0.047011692,-0.020612154,-0.027000176,0.004095499,-0.023688558,0.027426139,-0.023629218,0.027662981,0.002023194,0.088137865,-0.050217934,0.060399223,-0.064052545,-0.04272774,-0.11010141,0.0032196306,-0.013530563,0.03289594,0.0017740596,0.025395013,0.12794465,-0.0027256592,0.026563207,-0.041744184,-0.021594651,0.039385468,0.026623437,0.03481768,0.06263773,-0.03956231,0.026828121,0.015845355,-0.049748864,0.03987999,-0.0072534205,0.01920931,0.047508884,0.045713935,-0.022746665,-0.073852606,0.022480117,0.021989778,-0.02214517,-1.3758979e-33,0.100895256,-0.1255419,0.06139586,-0.0915276,0.010962366,0.004617223,0.03826143,0.051817127,-0.00044576015,-0.014258666,0.13426952,-0.009446508,-0.05016619,-0.060424443,0.021157889,0.06979398,0.07222366,0.029333293,-0.059109382,-0.094080016,-0.015082992,-0.021715678,-0.00042575866,0.04467826,0.060855918,0.015312513,-0.021924598,0.02136324,-0.009434114,0.09830341,0.025409335,-0.025069531,-0.061885357,-0.025563626,-0.05177201,0.009655613,-0.03813596,0.014793245,-0.0055119703,-0.02399756,-0.02844987,-0.03889412,0.10456701,-0.005649724,0.024129994,0.016745428,-0.08079949,-0.08256847,-0.00538038,-0.03315124,0.016494963,-0.003556039,-0.044901125,0.06627832,0.018057361,0.061215635,-0.06825745,0.0189611,0.08306112,-0.11836719,-0.07162993,-0.044910096,-0.018707402,-0.10843739,0.04109752,0.027002137,-0.0865063,-0.029370794,0.022098357,0.05152994,0.112210415,0.036314685,0.0029137372,0.039931186,-0.001516561,-0.020284915,-0.00916132,-0.08497451,-0.04468636,-0.0176546,0.02178147,-0.04917916,-0.075270824,-0.073418565,-0.027573083,-0.04663797,-0.013561075,0.063654974,0.0071110013,0.04133804,-0.029747855,-0.015174846,0.006616633,0.094666705,0.07518339,-1.9912072e-08,-0.0016082763,-0.114158995,-0.022312144,0.021778658,-0.060036298,0.044332635,0.03735339,0.013193066,0.049859796,-0.06171018,-0.045736115,0.07818605,0.032244164,0.025518287,-0.0032253265,-0.04802035,-0.036320247,-0.0076016495,0.020238575,-0.04387491,-0.08912999,0.007934199,-0.016650518,0.06162535,-0.040932212,-0.00308813,0.043561306,-0.032650042,0.058115073,0.051246732,0.0005768751,0.031394538,-0.01485993,-0.035782028,0.10171324,0.045675814,0.03212866,-0.016865768,-0.07820683,0.108241916,0.06634718,0.012252054,-0.06391707,0.03012064,0.08760566,-0.08214111,-0.01428743,0.17067021,-0.026425742,-0.033344213,-0.012509606,0.029543418,-0.07346134,0.0073110736,-0.021008817,-0.03168126,0.043437403,-0.08949871,-0.058783416,0.0018023624,0.009667483,-0.015197737,0.27619928,0.027960405 +3.1.2.4,Also hydrolyses 3-hydroxypropanoyl-CoA.,384,1.0,-0.0780071,-0.10683378,-0.04978243,-0.0197037,0.061003655,-0.041425463,-0.036233447,0.05323247,0.0023381503,-0.09565097,0.041669037,-0.051485106,-0.0077429265,0.017127698,-0.062121294,-0.024107698,0.021707648,-0.0027497173,0.016046733,-0.002235919,0.023513855,0.021656297,0.010923385,0.07573726,0.057732236,0.104632944,0.04901597,0.031777885,0.03606069,-0.06660852,0.016982669,0.038308233,0.015094957,-0.08449033,0.038387295,0.060034785,-0.032300927,-0.03939562,-0.0044030873,0.03005298,0.091875404,-0.10156436,0.043956976,-0.04613507,-0.028938804,-0.03753546,-0.027410178,-0.016398124,0.108908914,0.005523144,0.012487991,-0.08203153,-0.089409694,0.05255892,-0.03892639,-0.054314483,-0.025058884,0.04727013,-0.023877094,0.08717598,-0.03117525,0.036946837,-0.025357258,0.041652527,0.023214964,-0.0055903,-0.033432517,0.0033121135,0.005944796,0.030625315,-0.03303714,-0.028994935,0.061090693,0.037858583,-0.040530313,0.027803658,0.06986543,-0.077451594,0.061619323,-0.021563003,-0.07529454,0.05463611,-0.007064876,0.12326427,0.039370704,0.010937012,-0.041812934,-0.0508529,-0.029192025,-0.006548285,-0.01716303,0.04554733,0.028589698,0.05556745,-0.0942619,0.10688942,0.019499464,-0.019090215,-0.048582677,-0.014937706,-0.038090777,0.059147216,-0.015667873,-0.12075006,-0.02951496,0.018536817,-0.0073802164,0.077261545,0.082871184,-0.0036637778,-0.06302535,-0.016108219,-0.0017285907,-0.0075636283,-0.073135674,0.036618985,0.022282569,0.004621603,0.00975224,-0.014108081,-0.0015860985,-0.051633988,0.054889362,-0.022144193,-0.06833479,-0.025470022,0.044244215,1.273625e-33,0.0021092105,0.004085395,0.049313188,0.05428589,-0.026654178,-0.007899058,-0.085773535,-0.007536869,-0.023329582,-0.047945756,-0.011970304,0.023382995,-0.03362901,0.062188677,-0.0006227375,-0.12060602,-0.0020979005,0.019212645,0.0434174,0.008756343,0.009827822,0.044139154,-0.046878394,0.017362038,-0.028703075,-0.05337478,0.002521139,0.024473643,0.07394041,0.024739688,0.047988188,-0.0036934046,-0.046157427,0.017576298,-0.080596544,-0.00644735,-0.08507322,-0.09427523,-0.009403411,0.13564682,0.043772116,-0.022274563,-0.019166704,-0.014102377,0.04475663,-0.03727498,-0.024031125,0.0986198,0.019301249,0.007148646,0.06714145,0.013797281,0.07350178,0.0025166841,-0.04237567,0.03597569,-0.01846647,-0.0037952105,0.0063318433,0.01828468,-0.04894598,0.12219801,-0.034690693,0.0037701428,-0.035940394,0.008499033,-0.035843596,-0.008443768,-0.044685155,-0.008987331,-0.06272115,0.02666924,0.09514631,0.09408658,0.033225,-0.041275952,0.01019246,0.02975238,0.039683085,0.01608715,0.0072470303,-0.026442524,0.060537033,0.060702775,-0.061913174,0.06378783,0.04089993,-0.032182314,-0.0037707698,0.0022298528,0.057515673,-0.10423786,0.010762784,-0.016126493,-0.06385311,-1.5813494e-33,0.06370694,-0.100770146,0.01916096,-0.09052103,-0.0130643835,-0.044303466,0.058242142,-0.03489772,0.017933859,-0.030441,0.14021851,-0.008355085,-0.04335953,-0.06723923,0.009617532,0.11690482,0.030104183,0.00060021493,-0.036225792,-0.036222905,0.0499383,0.04448947,0.021601023,0.07959137,0.039042722,-0.014538755,0.012180839,-0.059588235,0.0064397296,0.11756366,-0.044406,-0.0069935443,-0.04624422,-0.0010542453,-0.07193275,0.02191637,-0.024539052,-0.053523995,-0.049459618,-0.0703463,-0.06751841,0.00785982,0.083818376,0.055162057,-0.003806724,0.08789435,-0.042541713,-0.029912848,-0.015079478,0.05957313,-0.03440301,-0.0046431706,-0.08465054,0.06340764,0.01175357,0.011799587,-0.02815991,-0.014821564,-0.00980809,-0.08131399,-0.017532557,0.01031711,0.0024270348,-0.06110608,0.08192719,0.08704346,-0.054186106,0.0003243078,0.042356607,-0.018280469,0.1368762,-0.00749255,0.029722398,-0.009533253,-0.0065412857,-0.04160476,-0.0030905693,-0.056456245,-0.072796896,-0.01891284,0.012824663,-0.015059831,-0.038246144,-0.056475427,-0.049904272,-0.086779855,-0.01969614,0.07395406,0.016965825,0.06491859,-0.025400287,0.031550657,-0.033839066,0.11034179,0.09630345,-2.0038792e-08,-0.01904843,-0.06734404,0.052531462,-0.019350832,0.011926234,0.05565196,0.002476083,-0.0060856193,0.064284034,-0.046428196,-0.018359672,0.043656934,0.016967,-0.026586104,0.0048265858,-0.042432126,0.0032600483,0.06435699,-0.02643513,-0.095413625,-0.12120708,0.0118329525,0.008018147,0.051875502,-0.009422596,-0.025372423,0.056533244,0.009783078,0.07209249,0.008724067,-0.015712697,0.01816773,-0.0013132674,-0.04471306,0.011266273,0.063460365,-0.0029382047,0.017292792,-0.08383584,0.053568326,0.014868286,-0.0393827,0.015767647,0.02444205,0.08167879,-0.0183857,-0.027451951,0.117100224,0.0068400674,-0.051043153,0.053561945,-0.010867462,-0.030301208,-0.027597342,-0.0834029,0.009578675,-0.026446112,-0.06944854,-0.019664017,-0.036677442,-0.045266666,-0.0023211176,0.22939257,0.03321251 +3.1.2.6,"Also hydrolyses S-acetoacetylglutathione, but more slowly.",384,0.99999994,-0.01358474,-0.06808708,-0.05307902,0.04191795,-0.0056884303,0.017106852,-0.06700948,0.057840955,0.021107204,-0.03842159,0.030714286,0.045745056,0.016459566,0.036122706,-0.07246923,0.010566997,0.06582181,0.009565148,-0.020539269,-0.0418256,0.02498163,-0.021250049,-0.020530157,0.034155283,0.07632592,0.06517817,-0.03263475,0.0029618454,0.009469998,-0.07512657,-0.012687591,0.021529188,-0.03417389,-0.026218979,0.008555838,0.08151276,-0.08060937,0.05185899,0.054267686,-0.00026186483,0.057178967,-0.058760908,-0.030091137,-0.034995314,-0.010207268,-0.021416936,-0.0634545,0.027380155,0.04003356,0.05824784,-0.010666274,-0.11187216,-0.04960152,0.014781761,-0.020133957,-0.028861806,-0.04992208,-0.009668597,-0.011154519,0.045006596,-0.029541418,-0.00941873,-0.030907437,0.022988567,0.015950799,-0.018277818,0.044544462,-0.051157042,-0.021520955,0.057889342,0.040007737,-0.019216368,0.0018010162,0.081159204,-0.086898595,-0.10431902,-0.02392829,-0.07307732,0.056982353,-0.029363757,0.03299157,0.02907128,-0.008910425,0.11112418,0.060877167,0.022280507,-0.016788768,-0.031672824,-0.05011512,0.022629289,-0.010796039,-0.0016661903,-0.019951232,-0.044761486,0.0058623683,0.021370376,0.016362138,-0.015195627,-0.109668285,-0.034695975,-0.022289488,0.056333076,-0.037393752,-0.08294239,0.016893927,0.036372826,0.012954284,0.027558543,-0.011177066,-0.020036116,-0.010750236,0.004307524,-0.015122332,-0.03161473,-0.056155413,0.076850176,0.04231102,0.011493564,0.0072009927,-0.0035555528,0.0028511584,-0.031544793,0.049669947,-0.02714057,-0.010725595,0.046249736,0.034051187,1.7299214e-33,0.030330384,-0.0070282198,0.01360312,0.057445522,-0.021906525,0.03186715,-0.044661492,0.011451312,0.018332193,-0.033666253,-0.072196424,-0.036379408,-0.037218362,0.019581383,0.002603105,-0.048207838,-0.00022974491,-0.0132881375,0.03761409,-0.07845387,0.0017671481,0.039604485,-0.063558385,0.0046325712,-0.03473139,-0.015708003,-0.0063287583,0.023687067,0.04781025,0.016724838,0.02904035,0.03142961,-0.021989528,-0.0062542697,-0.0064236987,0.033268172,-0.009638561,-0.06605853,0.05970014,0.060421612,0.04935584,-0.0034137797,-0.060070302,-0.065837376,0.0027462451,-0.013273834,-0.10688115,0.037901726,-0.020095339,0.06231814,0.06469286,-0.004896042,0.03203929,0.020130621,-0.09811895,0.031076135,0.00240902,-0.03373128,-0.007968135,0.09308077,-0.01967385,0.07915622,-0.016903624,-0.00043707975,-0.014627082,0.024114456,-0.059308153,-0.046870418,-0.09442186,-0.0055632396,-0.05168724,-0.0044234493,0.1338985,0.062722184,0.031568408,-0.062524095,0.0571074,0.0343697,0.006347532,-0.02664267,0.034134533,-0.023861513,0.04178317,0.07437207,-0.017999684,0.0123070115,-0.0048986645,-0.09750523,0.016727453,-0.022654314,-0.012317571,-0.07874446,-0.07253147,0.008704087,-0.029442845,-3.4791973e-33,0.0790216,-0.13595757,0.08737314,-0.0019944308,0.0076055876,0.08713432,0.044703495,0.030168202,0.046303198,0.031105254,0.12373629,0.0073758396,-0.08731698,-0.054554917,0.013025534,-0.012688917,0.061522834,0.017953893,-0.002347198,0.037411384,0.0002700245,0.10106697,0.036492646,0.07929473,0.10499198,-0.023031505,-0.01592351,-0.0053564156,0.01825934,0.08966192,-0.013892177,-0.004296321,-0.07302041,-0.13050582,-0.09266175,0.07561142,-0.04572967,-0.009942407,-0.12001586,-0.051643513,-0.009214555,-0.024735007,0.0746768,0.07992827,0.12102767,0.07677404,-0.08899878,-0.031139938,-0.05201645,0.016109394,0.033212792,-0.021084309,-0.073189445,0.098005176,0.07925554,-0.04445338,-0.053240076,-0.07941266,-0.005039843,-0.050465234,-0.057309672,-0.018341938,-0.04961731,-0.045122188,0.048248604,0.057117842,-0.014737941,0.006938546,0.047499925,-0.010127585,0.030488547,-0.06520597,-0.009891717,0.07660688,-0.031463906,-0.023525758,-0.031442042,-0.06911537,-0.044350952,-0.08015713,0.010847852,0.041064605,-0.04019335,-0.06454731,-0.051037736,-0.037711456,-0.041672852,0.06434743,-0.0071710423,0.07187813,-0.046505257,-0.0067251846,-0.06514225,0.031546704,0.017463947,-2.3985908e-08,0.04867819,-0.03839093,0.14483912,-0.014586345,0.00082036457,0.011178428,0.09667745,0.09906778,0.093870714,-0.12652889,-0.06256231,0.14177547,0.058658283,-0.01385415,-0.047109943,0.011170217,-0.0062777624,0.039585527,0.014891186,-0.0138646765,-0.11275792,0.009182951,0.033582013,-0.041804165,-0.005454081,-0.030365892,0.091499195,0.06429503,0.055024512,-0.03595537,0.033648733,-0.014626836,0.015974125,-0.018606376,-0.013363948,0.048547097,-0.0061910343,0.03036683,0.013632883,-0.0105454745,-0.06876023,-0.018826311,-0.003244154,0.061040763,0.016275465,-0.03449231,0.030183004,0.010391923,0.05937329,-0.041642882,0.035118762,0.009767598,-0.060268443,-0.083746396,-0.054850932,0.019751972,0.027919266,-0.10985203,0.0037760441,-0.09571567,-0.006244858,-0.044103358,0.16448575,0.11114159 +3.1.2.12,"Also hydrolyses S-acetylglutathione, but more slowly.",384,1.0,-0.008553111,-0.06645848,-0.05924047,0.038806822,0.013290604,0.017318266,-0.06933016,0.056643523,0.026276933,-0.03207304,0.030650103,0.054549575,0.0117782075,0.04344099,-0.063855655,0.022151534,0.047328096,0.015631994,-0.027113004,-0.04354273,0.033376407,-0.021771012,-0.021485964,0.033205338,0.07166983,0.047773004,-0.032872196,0.0064751557,0.006148446,-0.06997063,-0.009713468,0.014756604,-0.03552161,-0.024973879,-0.0027554065,0.086079486,-0.06803167,0.06257598,0.061638508,0.015372769,0.052466318,-0.06375823,-0.04417933,-0.03088785,-0.006522755,-0.02018705,-0.051894467,0.026939532,0.038892962,0.059007403,-0.011827979,-0.092270136,-0.04441823,0.0018351348,-0.022861062,-0.03087009,-0.067415364,-0.014229286,-0.004838783,0.0460929,-0.04928809,-0.012717697,-0.035516698,0.024030538,0.02336839,-0.023150636,0.040059596,-0.052524157,-0.002753105,0.06547274,0.04219466,-0.010654172,-0.00915813,0.08525977,-0.0968834,-0.097773165,-0.021799045,-0.0875276,0.049398486,-0.02283349,0.024571901,0.032087676,-0.0048486264,0.11813653,0.06697578,0.011070905,-0.01981517,-0.02895461,-0.05368321,0.028220432,0.0013270739,-0.0067017237,-0.01736065,-0.03288995,0.019497449,0.018373817,0.015416932,-0.028397532,-0.11460084,-0.0349375,-0.035771787,0.04363347,-0.02516454,-0.07146897,0.016394174,0.046319604,0.02349237,0.023962183,-0.017289285,-0.011323454,-0.00011977612,-0.003225987,-0.023499267,-0.022618726,-0.06636719,0.086028084,0.03698739,0.01970434,-0.0132022165,0.0057783048,-0.0019127454,-0.03341796,0.045687184,-0.01668581,-0.010217633,0.055707425,0.03422443,9.774412e-34,0.028550597,-0.0031275623,0.012750633,0.047723163,-0.0141928885,0.042887416,-0.05038852,0.007100624,0.013885352,-0.029349044,-0.04806572,-0.027140327,-0.026789682,0.013766612,-0.0055380035,-0.06061225,0.01048248,-0.012060026,0.038116276,-0.07449483,-0.00076962606,0.047481697,-0.064958915,0.002473945,-0.034643352,-0.03528845,-0.0007338474,0.024290513,0.03987515,0.014584507,0.033223286,0.020358838,-0.01782991,-0.008442136,-0.018710714,0.05150915,-0.011641642,-0.06777314,0.05988701,0.06411255,0.044627197,0.0012553015,-0.055685997,-0.062941775,-0.010975354,-0.0066512804,-0.11051683,0.035666347,-0.016876213,0.05940164,0.057029333,0.0024312628,0.017061856,0.021049945,-0.080581136,0.018549498,-0.004127655,-0.035803366,-0.0030961307,0.09445638,-0.018926844,0.0715357,-0.032049365,0.007576818,-0.009692007,0.01013062,-0.061028287,-0.045571595,-0.09176868,-0.0067196176,-0.056140255,0.00808473,0.15104394,0.055105466,0.033534892,-0.055400733,0.05589035,0.04177861,0.008339369,-0.028650412,0.032713655,-0.026181666,0.043495104,0.08824953,-0.018663159,0.018827975,-0.0129464725,-0.07350875,0.011171492,-0.030865908,-0.005391484,-0.09411137,-0.06507604,0.00745664,-0.036905013,-2.6269834e-33,0.07014793,-0.13728426,0.08563295,0.0009535658,0.007974787,0.101212904,0.051803607,0.024000447,0.01915568,0.027277995,0.121200494,-0.00048802432,-0.094005205,-0.047429748,0.009992597,-0.002834873,0.061745834,0.026934355,-0.0024131404,0.03079586,-0.006637262,0.11384808,0.04777698,0.07593058,0.107005,-0.023594504,-0.019551134,-0.009041635,0.0015592556,0.10176871,-0.009348071,-0.0060830005,-0.078972,-0.1280205,-0.081178956,0.07967853,-0.053430986,-0.0110204285,-0.11745973,-0.048784174,-0.011960767,-0.02910748,0.08547152,0.05350686,0.111844376,0.08696296,-0.084737696,-0.020942764,-0.0528015,0.013316393,0.030137088,-0.0148527175,-0.07250116,0.0958681,0.07944452,-0.0551603,-0.04520484,-0.080964215,-0.006711807,-0.05137619,-0.06209122,-0.032798488,-0.05381194,-0.053899106,0.044260565,0.047436938,-0.014501127,0.013218923,0.054908834,-0.008624462,0.026298145,-0.062721565,0.009106265,0.08427673,-0.027492005,-0.016499687,-0.033265874,-0.07773566,-0.040538948,-0.076360665,0.0024728891,0.04388918,-0.034245025,-0.065214366,-0.052026078,-0.025397986,-0.03517463,0.056922812,0.0008085987,0.0748609,-0.040760055,-0.018069614,-0.058516663,0.030900527,0.022645526,-2.2367075e-08,0.03803915,-0.04837204,0.14477134,-0.012908935,-0.0011265031,0.01897707,0.10253442,0.09625838,0.08431815,-0.13576947,-0.055625778,0.13464288,0.073582746,-0.0065562674,-0.03647153,0.0033356352,0.011727532,0.052148163,0.020072144,-0.026912708,-0.118822,0.004439077,0.03480111,-0.030186875,-0.017114127,-0.021374462,0.0909387,0.0662543,0.06327407,-0.0541968,0.031086355,-0.020428099,0.0069042156,-0.014605854,-0.019073002,0.04637046,-0.0060969167,0.027990604,0.015049953,0.0014791057,-0.06809907,-0.027212298,0.001827271,0.0669241,0.02006786,-0.042781837,0.032801107,0.0065923072,0.052536834,-0.0440308,0.03306653,0.008383396,-0.04680489,-0.07626939,-0.053326193,0.014367424,0.016431525,-0.11064483,-0.0009017013,-0.1018137,-0.0010018361,-0.035360895,0.16236587,0.102624625 +3.1.2.14,"Acts on acyl-carrier-protein thioesters of fatty acids from C12 to C18, but the derivative of oleic acid is hydrolysed much more rapidly than any other compound tested.",384,0.99999994,-0.037656143,-0.05337508,-0.026802745,0.050579164,0.08748173,0.025599819,-0.07820081,0.09626645,0.017832868,-0.046278767,0.030843321,-0.055333097,-0.09768955,-0.01413493,0.039928276,-0.010884477,0.05888126,0.038696397,-0.089821965,-0.03181901,-0.047340035,-0.01151446,-0.005655859,0.0060528778,-0.008747481,-0.058919806,-0.0021035085,0.009035962,-0.015915398,-0.07395478,0.011696108,-0.025749443,0.045819353,-0.028374294,0.018577363,0.016990129,-0.042230077,-0.09608941,0.078498565,-0.0024272245,0.07500365,-0.07307762,-0.023168506,-0.029340593,-0.004651121,-0.080607265,0.015778821,0.06909648,-0.0082612485,0.026788246,-0.030619975,-0.003388448,-0.0545621,-0.0259681,-0.111242406,-0.01971835,-0.03055597,0.0019337301,-0.04423429,0.04379498,-0.03958276,0.0020550797,0.005827334,0.057213243,-0.052338887,-0.030579284,0.036055967,-0.07207517,0.09964839,0.0070918975,-0.050426237,-0.0028628972,0.021367077,0.069955245,0.062017355,0.028972728,0.0070615,-0.049104217,0.07693412,-0.10219339,0.004491091,-0.019515915,-0.005944978,0.025681693,0.024593364,-0.039930686,0.05117779,0.018137228,-0.044298753,0.03548407,0.11660229,0.029656025,-0.03179794,-0.008048602,-0.08286004,0.022822164,0.04105233,-0.035620004,0.01911822,0.0032174904,-0.02882868,0.039659172,-0.03429703,-0.04473944,-0.09153961,0.024685109,0.009975337,0.008005578,-0.0518843,0.0024588623,-0.008010949,-0.04746835,0.035507914,-0.007249143,-0.09186788,-0.0059070685,-0.034542143,-0.110146314,0.00024425908,-0.05502719,-0.0036435723,-0.07839899,0.08667071,0.06993855,-0.043365713,-0.04139721,-0.018839441,1.820059e-33,-0.0055715274,-0.0025128785,-0.026020674,-0.06156308,-0.0027160845,-0.055127323,-0.11082335,0.039902348,0.0044096904,0.04993429,0.0032462194,-0.0029355094,0.0070272246,0.040939376,0.05467876,-0.07943324,0.022001097,0.07537588,0.048902992,0.023508929,-0.023275603,0.0493995,0.027726049,-0.06812456,-0.01591854,-0.012883143,-0.031767465,0.026205834,0.03984688,0.019892048,-0.023510413,-0.05099878,-0.04302271,0.05158435,0.028725224,0.06659589,-0.035276685,-0.023879673,0.016616363,0.062203255,0.06375848,0.023741592,0.034543473,-0.041189916,-0.049986538,0.021924539,-0.056437477,0.07470655,0.02182634,-0.04608101,0.012932329,-0.031506926,0.041718233,-0.0032197714,0.023412328,-0.013530514,-0.06931534,0.004928352,0.02172118,-0.009905737,-0.01125522,0.06299266,-0.04085345,0.022695933,-0.08387336,-0.019747188,-0.08532629,0.03582353,-0.029876584,0.042516254,0.010000045,-0.010260132,0.11553911,-0.042615224,0.073055126,0.0126133645,-0.04681453,0.088178106,0.039097972,0.013996232,0.05098871,-0.007851274,-0.005607152,-0.013902745,-0.059476186,0.034957856,-0.045454945,0.067625105,0.031664334,0.021298282,-0.0027814356,-0.061963174,0.024870822,0.029351382,0.042460818,-4.7699496e-33,0.056904294,-0.07135119,0.046983737,0.002923326,0.008188035,-0.002954206,-0.012183227,0.00075862015,0.007886398,-0.00745157,0.15864725,-0.020965239,-0.030920338,-0.08048684,-0.0005894803,0.0375549,-0.010341966,0.035548083,-0.045179386,-0.028473299,-0.07829646,-0.08851325,-0.015883027,0.07145653,0.030038157,0.02397152,-0.049820542,0.025000041,0.037454795,0.0736941,-0.012876395,0.021013565,-0.06609726,-0.012850664,0.016343905,0.06466491,-0.010147291,-0.000780121,-0.0030828514,0.077359445,0.04977224,-0.03485917,0.03794343,-0.043968692,0.09400699,0.048492935,-0.089279145,-0.071925186,0.025743192,-0.054749757,0.08167616,0.006129742,0.014365356,-0.021175219,-0.009878334,0.15810136,-0.004402853,-0.051134385,-0.022253688,-0.08725797,-0.042531025,-0.053277023,-0.0024755793,-0.085436724,-0.034244932,0.035888836,-0.12719248,0.0074933465,0.03350179,0.015755743,0.06185096,0.0026222002,-0.011097905,0.029663024,0.012225435,-0.03942702,0.021527335,-0.12294995,-0.05151929,-0.021618504,0.052792177,-0.043774575,-0.015653124,-0.09315437,-0.036256,0.061438277,-0.03545967,-0.051047917,-0.008863436,0.061164815,-0.018583797,-0.0055558817,0.009506497,0.06563499,0.028804122,-3.213789e-08,-0.017637879,-0.03360511,0.05014541,0.025526986,-0.053821202,0.03156301,0.014936015,-0.05503311,0.018019795,-0.06809559,-0.0708567,0.105297126,0.023848852,0.025742184,0.020201404,0.01620896,-0.08578945,-0.0397474,0.007364788,-0.053815998,-0.047935948,0.008891158,0.04023947,-0.0013184544,-0.034783836,0.016109906,0.022941876,-0.022935363,0.009235011,0.009539544,0.039443374,0.03154218,-0.022075731,0.073083825,0.12661979,0.015651325,-0.005216284,-0.04633056,-0.10725506,0.13498175,0.041153096,0.046654444,-0.109496035,0.047429938,0.12207794,-0.06428055,0.007980325,0.101476416,-0.058410954,-0.00934631,0.0031799963,0.047898278,-0.10206342,-0.00044946335,0.033054,-0.092151724,-0.033879086,-0.04380667,-0.045312617,-0.0007797657,0.029945504,0.011154532,0.23665768,-0.02055893 +3.1.2.15,"Acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin. May be the same as EC 3.4.19.12, ubiquitinyl hydrolase 1.",384,0.99999994,-0.038161207,-0.0522698,-0.026596582,-0.012257974,0.025979234,0.03503187,0.03888121,0.023450034,0.02878671,-0.05172592,0.02453968,-0.02693425,-0.05476255,0.0061122035,-0.051527288,-0.009217383,-0.025598189,-0.05081123,-0.040992014,-0.07511181,0.1188886,0.0415122,-0.043118708,0.019082293,0.028235642,-0.036271047,0.048012327,0.024434876,0.041766953,-0.1451292,0.00085965125,-0.0940213,0.037226565,-0.043236826,0.018827645,0.10835095,-0.11206449,-0.08154954,-0.0011363071,-0.013539351,0.1145571,-0.055773016,0.0005566538,-0.009828216,-0.017092977,-0.039286427,-0.06340268,0.015148004,0.04000846,0.07502174,-0.012108509,-0.031458903,0.02371372,0.07851168,0.03088838,-0.022350635,-0.05906377,0.017755697,0.014630389,-0.0094256,-0.014413918,0.05116496,0.025356175,-0.03178395,-0.03657064,-0.023482377,0.0728806,-0.05737416,0.02180108,-0.04797158,-0.050862465,-0.04936555,-0.040871378,-0.015056166,-0.014262756,0.00983389,-0.09131623,0.01156925,-0.027974632,-0.03442849,0.041573387,-0.03547952,0.030825565,0.067325845,-0.036459144,-0.013340645,-0.055912286,-0.07500101,0.012716806,-0.03670848,0.03805719,-0.052378614,-0.034040917,0.032527387,-0.044298433,0.007477337,0.0074721705,0.018102566,-0.0006005213,0.01211424,0.0037531098,0.07330809,-0.09016871,-0.074766316,-0.05672207,0.0434172,0.004166356,0.075266674,0.053688165,-0.0224048,-0.062138718,-0.023005651,0.04544988,0.012924955,-0.027750932,0.045764323,0.02417962,-0.05325356,0.021923997,-0.09149118,0.037354954,-0.022847543,0.07094425,0.0674618,-0.030446349,-0.015450829,-0.11797297,5.128855e-33,0.15385677,-0.011623684,0.030503621,-0.0007617846,-0.0052338615,-0.0022120841,-0.10171135,0.02726094,-0.039397914,-0.11963411,-0.009328929,-0.006097766,0.023617687,0.023547096,-0.0097611835,-0.11316758,-0.028389808,0.021488925,0.08038377,-0.021205723,-0.012548495,0.011877939,-0.09872937,0.036627837,-0.012734758,0.046002254,-0.023608398,0.07669456,0.017747296,0.026711373,-0.029188251,0.0036792434,-0.08219336,0.040745452,0.011502378,0.0126548,-0.050339058,-0.011795525,0.045080204,0.029105937,0.026548555,0.0119369,-0.02015553,-0.118055224,0.105479546,-0.007182112,-0.0454149,0.14666629,0.031573083,0.071558274,0.059594024,-0.063615516,0.12597947,-0.048290294,-0.05235542,0.058509313,-0.02588979,0.010189475,0.022020506,0.08576975,0.037868924,0.0731931,-0.07766144,0.002699278,-0.06605368,0.06834099,-0.05640825,0.015302047,-0.026657192,0.04582327,-0.043460153,-0.009568983,0.09732032,0.019355288,-0.0155207515,-0.05349126,-0.1066293,0.04973006,0.004221331,0.049674153,-0.039554935,0.014013945,-0.06150591,-0.021126263,-0.05540373,0.035640277,0.072439246,-0.069511496,-0.010959905,0.04543179,0.016427433,-0.022840196,-0.047151238,0.04595553,-0.0050211237,-6.72753e-33,0.14077656,-0.07429968,0.049233764,0.042681772,0.059037965,0.00076800986,0.08056158,0.04155378,0.042709045,-0.03758022,0.0885921,-0.030391697,-0.017461082,-0.079396866,0.023445755,-0.01385724,-0.05104884,0.024447793,-0.023573855,0.030559909,-0.006425306,-0.05322364,0.002215363,-0.013848795,0.06385736,0.0007587989,0.018917548,0.08119342,0.036930993,0.019927144,-0.068076745,0.018900614,-0.086086884,-0.023144178,-0.039621018,0.021947594,-0.044056214,0.013519688,0.037299477,-0.08813053,0.019913705,0.004076915,0.05443833,0.10022827,0.09016028,0.1278966,-0.027788758,-0.020718152,-0.0633853,-0.060564626,0.025384078,-0.013252722,-0.033354618,0.07019139,-0.047985464,0.10513295,0.06345161,0.010198657,-0.0015968364,-0.011110414,-0.016777836,0.043628212,0.0019350442,0.010044447,-0.007475573,0.004671811,-0.009115905,0.012226184,0.11297193,0.038283918,0.098423176,-0.13769215,0.04777348,-0.000525119,0.002420465,-0.043117963,-0.08895467,-0.025844527,-0.039366066,-0.0207314,0.024264853,0.03941131,-0.03490293,-0.04606717,-0.012708471,-0.027646227,0.013014479,0.13022092,-0.06302554,0.07954125,-0.084306866,0.029984167,-0.062200144,0.05485353,0.028891131,-4.43351e-08,0.023332926,-0.048171833,0.021386703,-0.028545873,0.07801899,0.0067699063,-0.0074804504,0.04454116,-0.0012970328,-0.028419135,-0.0077048824,0.022535115,-0.021661544,-0.040258523,0.034182563,0.015560333,0.011215068,0.037671383,-0.014944466,-0.021310583,-0.097545415,-0.006447823,-0.043869257,0.022763401,-0.053488515,-0.012050994,0.020187054,0.033527974,-0.04211629,0.009458809,0.029169938,0.050051387,-0.012081179,-0.077121966,-0.002565636,0.056367192,-0.050026204,-0.043265227,0.028910087,-0.018684354,-0.034453828,-0.007263265,-0.04113422,0.025890341,0.04859855,0.00092709454,-0.015295416,0.02685897,-0.02304635,0.00958954,-0.004442089,-0.08077375,-0.040216368,-0.04220632,-0.060344733,0.019968083,-0.0364449,-0.087850995,0.048142,-0.06224589,0.050888024,0.015952352,0.11307734,0.011632323 +3.1.2.16,"In the proteobacterium Rubrivivax gelatinosus, this enzyme modulates the activity of EC 4.1.3.6, citrate (pro-3S)-lyase, by converting it from its active acetyl form into its inactive thiol form by removal of its acetyl groups [2]. The activity of citrate-lyase deacetylase is itself inhibited by L-glutamate [2].",384,0.99999994,-0.05038073,-0.07314848,-0.10806607,-0.023941282,0.038474835,0.072728604,0.023463095,0.0868551,-0.01236987,0.05198404,0.047762234,-0.009065486,-0.033724915,-0.006232099,0.029349953,0.016212113,-0.017095126,-0.011664538,-0.04851522,-0.084157415,0.07316966,0.01153398,-0.061532058,-0.023132809,0.00069641665,-0.052492414,0.060741518,-0.06768216,-0.032568987,-0.09403871,-0.003847928,-0.02108719,0.08672554,-0.057312984,0.044574104,0.0015989244,-0.13871312,-0.13761844,0.04841147,0.04311722,0.061941925,0.046352193,-0.047897384,-0.08116527,-0.047519628,-0.030878935,0.0013612838,0.00028827542,0.09210297,-0.033006985,-0.014863921,-0.08210451,-0.022571065,0.046184108,-0.10876342,-0.040192906,-0.008178619,-0.009969974,0.017945593,0.018149737,0.044748966,0.037220307,0.04635593,0.039619595,-0.0038075563,-0.07103696,0.044214744,-0.034333568,-0.025873976,-0.043805193,-0.051009297,-0.050472576,0.037046842,0.07899695,0.043013174,0.008052986,0.00590374,-0.027616734,-0.047528382,-0.042481016,0.054005496,0.030802527,0.039047547,0.018371208,-0.022195965,-0.008355984,0.003502157,0.013369966,0.039833713,0.02504512,0.08029875,0.013840117,-0.069744825,-0.022729529,-0.03060287,-0.017660404,-0.0127813555,-0.015241979,-0.04894587,-0.020916093,-0.0013567199,0.10503312,-0.0044696867,-0.120544516,-0.030781697,0.040350035,0.017677702,0.046286553,0.003346738,0.025002128,0.0363665,-0.056495503,-0.03148637,-0.018819556,-0.053417824,0.092754744,0.08240916,-0.035934135,0.014498575,-0.034496542,0.09884448,-0.017073233,0.10980166,0.019524928,-0.057492997,0.092188776,-0.05901004,3.2191927e-33,-0.019488573,-0.037648365,-0.028090628,-0.0009868073,0.010349697,0.006794249,-0.13699088,0.0027485345,0.035057794,-0.07768426,-0.078334436,-0.014138037,0.028552946,-0.02425616,0.0029428382,0.009292402,-0.015218786,-0.012340526,0.06938099,0.028677925,0.052204464,-0.0062843678,-0.05592855,0.004512337,0.01206715,0.09917036,0.06566804,-0.024493871,0.008603566,-0.0011623766,-0.00583106,-0.050995044,-0.08497448,0.053043295,0.036539372,0.03663466,0.002976185,-0.07680461,0.022353046,0.042678654,0.037927587,0.023986643,0.043571156,-0.057863172,0.052079193,-0.066658564,-0.039674066,0.055648476,0.036186107,0.070855305,0.040023003,-0.052332107,0.12906156,-0.01621601,-0.052308936,0.0293734,-0.02524595,0.015102178,0.07569338,-0.0059693116,0.024195882,0.044125605,-0.045549273,-0.0058055753,-0.055571485,0.07611234,-0.14820631,-0.04803665,-0.0055764606,-0.0062076906,-0.10550711,-0.019708272,0.111177176,-0.009319898,-0.0070800995,-0.107891366,-0.10509223,0.026503624,-0.07884637,0.06625532,0.015365655,-0.0041299104,0.001623247,0.028935049,0.07315734,-0.018558541,-0.0058379415,0.036905836,0.0067400965,-0.027587451,0.074484274,0.047300696,-0.07419903,0.107258,0.027429532,-3.8441e-33,0.07681007,-0.07341887,0.079486616,0.0030852188,-0.008900006,0.034214173,0.016184706,0.02312261,-0.035774615,-0.04018788,0.0790932,-0.011927419,-0.013948008,-0.09559809,0.052693207,-0.0021941618,-0.05666744,0.024512367,-0.07026905,-0.03828258,-0.03419661,0.012332413,0.05879768,0.0028959813,0.07234595,-0.036108553,0.03788664,0.03161298,0.036865346,0.017561477,0.03179462,0.015755171,-0.047040917,-0.036355935,-0.08769818,-0.012050735,-0.015228151,0.0111397365,-0.010168218,0.021861581,0.029706733,0.06766693,0.03905059,0.036568996,-0.005514999,0.10551005,-0.02372697,0.01060563,0.008740872,0.015420504,0.064480945,-0.04907146,-0.03882561,-0.0041908994,0.030154197,0.04594395,-0.00720883,0.010522334,-0.042411476,-0.015692322,-0.032163247,-0.07469055,0.029201528,-0.009418737,0.08784531,0.026925867,-0.012393399,0.13357683,0.077004135,0.009715771,0.124755,0.024110576,-0.06500912,-0.06782474,0.012519273,0.025918948,-0.0862101,-0.080365546,0.019110315,-0.06926765,-0.007880304,-0.061235722,-0.013766957,-0.040717162,-0.0031427736,-0.023403043,-0.06797079,0.101162985,-0.05425539,0.02119406,-0.012308187,-0.057583727,0.0020640944,0.044109907,0.05874208,-4.0676657e-08,0.008393739,0.0040852865,-0.02151698,0.0061020013,0.04721903,-0.031716503,-0.020064853,0.033572186,0.06285266,-0.0241675,-0.019478863,0.018654505,-4.8267088e-05,0.015854497,0.048850276,0.0849696,0.02735339,0.10009278,0.0072708856,0.052528553,-0.024961356,-0.08061104,-0.12440881,0.05317484,-0.038932085,0.012522383,0.047966626,0.062618546,0.0021591813,0.005118576,-0.05831853,0.038715184,-0.03010951,-0.011670689,-0.063080154,-0.00518582,0.011763935,0.005175716,-0.037895102,0.012621766,0.009961782,-0.014890952,-0.072467394,-0.020354152,-0.10071167,-0.040167633,0.07411251,0.056122396,-0.042941257,-0.056664295,0.01766871,-0.03580816,-0.008380072,0.015212938,-0.03728672,-0.005811078,0.015193659,-0.03122713,-0.04886985,0.004413611,0.05437112,0.0146645885,0.15160336,0.030438302 +3.1.2.18,Requires ADP; inhibited by NADH. Maximum activity is shown with propanoyl-CoA.,384,1.0000001,-0.068141036,-0.029361896,-0.04816839,-0.019454734,0.052132588,0.038971946,-0.065192364,0.079270765,-0.033328887,0.048657175,0.013589615,-0.019173093,-0.10880571,0.121641524,0.015483264,0.08280983,0.06843034,-0.030109247,0.06897193,0.037732195,0.036628593,0.031996734,0.031140942,0.032585535,0.029974274,0.01580821,0.009179754,0.047923777,0.019911854,-0.035854142,-0.0352594,-0.0031125224,0.046035722,-0.034418624,0.0435029,0.037897218,-0.109862626,-0.013127333,-0.03490615,0.011555108,0.052754488,-0.063141465,-0.064759836,-0.0073624533,-0.0028245568,-0.07522065,-0.008394651,0.05658042,0.06999885,0.039548706,-0.05664522,0.03393384,-0.013124122,0.033792067,-0.047442783,-0.0733001,-0.028973896,0.0024322653,-0.017723145,-0.05416468,-0.025734402,-0.010036475,-0.07733624,0.03440458,0.05232756,0.011055283,0.0654149,-0.021090021,0.0014832123,0.05354482,-0.046710376,-0.017339606,-0.012912339,0.012459035,-0.021102687,-0.0083713755,-0.04407367,-0.10075764,0.1039336,-0.04903298,0.022971015,0.028725237,-0.07000396,0.095688246,0.0758555,0.053314514,-0.03424965,0.030614963,-0.039896812,-0.018769545,0.0073415013,-0.010138896,-0.053205874,0.03175986,-0.09733635,0.040039837,0.031767555,-0.019866478,-0.039132845,-0.0062322537,-0.075350165,0.10323803,-0.044658538,-0.022670723,-0.06341585,-0.006236185,0.006114717,0.050819688,-0.01792922,0.06729534,0.0233101,-0.019918388,0.027633434,-0.011068467,0.0038389354,0.060764536,-0.06504151,-0.03184582,-0.052619737,0.0047578397,-0.009962512,-0.05493388,-6.036147e-06,0.033534553,0.05328968,0.011421535,-0.00014290833,-1.3026806e-33,0.13712972,-0.01415413,0.032418873,-0.0048918813,0.02595488,0.014880916,-0.08493913,0.003279443,-0.0084571075,-0.028084803,-0.00543674,-0.10313252,0.036911137,0.07694931,-0.030178186,-0.00010887745,0.012385671,-0.030279404,0.042809233,-0.030767487,0.032570846,0.033746917,-0.055113498,0.043876097,-0.004372388,0.007896156,-0.06819574,0.11050704,0.0026881725,0.009030517,0.05080967,-0.07158539,-0.09737226,0.018698111,0.045425035,0.0035149553,-0.10485864,-0.08162184,0.02296106,0.07725629,-0.04227261,0.056726977,0.01456952,-0.0152459955,0.053723447,-0.06472239,-0.016128741,0.08380604,-0.033805195,0.08414995,0.0826236,-0.06672343,0.058251224,-0.058873843,-0.04389382,0.0080792755,-0.04411073,-0.049068984,0.014994504,0.09090778,0.014565534,-0.0011385006,-0.026867721,0.116733715,-0.04898027,0.039556,-0.1396516,-0.08360624,0.030766288,0.007595491,-0.01321697,-0.017849123,0.10595962,-0.00048477153,0.011858043,-0.021489901,0.057286303,0.046755902,0.033510625,0.024600731,-0.03436638,-0.1276893,-0.01196537,0.039466605,-0.011664152,0.01685656,-0.00756468,-0.033252813,-0.02068093,0.010509232,0.108970456,-0.016239325,-0.027893854,-0.025069935,0.020674435,-1.3143646e-33,0.08064249,-0.01699266,0.045245316,-0.11204785,-0.069909394,0.12752426,0.0073562693,-0.0763184,0.026641658,-0.080327444,0.10061811,0.03533796,-0.0056096115,-0.014892026,0.023853669,0.040293355,-0.02713484,0.041676424,-0.009067911,0.013639529,-0.00016723745,0.11822825,0.010833176,0.049644474,0.07389105,-0.090931125,-0.06389561,0.023241725,0.024383629,0.05597226,0.0051755807,0.029023033,-0.15613636,-0.04000074,0.062060576,0.038168743,-0.051110767,0.01415262,-0.06843402,0.047892995,-0.01436439,0.0041953735,-0.04161369,0.036612056,0.07657805,0.021745998,-0.04479509,-0.07625704,-0.03794544,-0.030377558,0.03173254,-0.0076630497,-0.034473438,-0.0039120545,0.035526782,0.08337732,-0.007145016,-0.01735246,0.05749569,-0.06711251,0.027212678,-0.01997857,-0.054700233,-0.035705097,0.024035586,0.034134395,-0.014952323,0.05241977,0.09463449,-0.06571411,0.03419526,0.07840261,0.09269094,0.025039414,-0.06518011,-0.023620384,-0.07128985,-0.040006585,-0.037915464,-0.03247639,-0.048140135,0.034565385,-0.050322827,-0.05866651,-0.09052969,0.019194478,-0.01858558,-0.0343645,-0.00177031,0.033531215,-0.0334027,0.018775394,-0.013725583,0.06689571,-0.0098704,-2.4927838e-08,0.041483995,0.0177544,0.06795886,-0.07809949,-0.0058558863,0.020136101,0.08206652,-0.015963437,0.014826613,-1.4428067e-06,0.053332638,0.13291244,0.055990625,0.036027677,0.064758815,-0.041688617,0.0011679587,-0.010078559,-0.087759696,-0.098503366,-0.067126475,-0.06012693,-0.07450817,0.04748921,0.009784192,-0.05545154,0.016506866,0.007496283,0.039193306,-0.044582877,0.033085153,-0.03926016,0.008561019,-0.017083438,-0.013895111,0.050246686,0.028396921,-0.0062260833,-0.06063557,0.08248756,-0.060950644,-0.047461316,-0.0238496,0.024540469,0.04375637,0.014263026,0.037825417,-0.003000346,-0.06449234,-0.021346701,0.038234852,0.012540925,-0.049896922,-0.050353706,-0.072071426,-0.008893238,-0.028185809,-0.027962727,-0.053833287,-0.07840109,0.031007245,0.043065287,0.061957385,-0.038023774 +3.1.2.19,Requires ADP; inhibited by NADH. Maximum activity is shown with nonanoyl-CoA.,384,1.0,-0.06309975,-0.041182354,-0.04823949,-0.021733705,0.051472187,0.022743475,-0.054182824,0.060446456,-0.010434913,0.02211848,0.022064568,-0.026146458,-0.08568922,0.112410605,-0.00036768962,0.049520098,0.06454448,-0.03752481,0.07947826,0.032510508,0.022452883,0.029704837,0.036120083,0.0017105774,0.027575463,0.012728164,0.01143272,0.022587417,0.02358315,-0.05157561,-0.04012721,0.014475613,0.044172663,-0.03282399,0.027580319,0.056367937,-0.092947535,-0.009464538,-0.031394932,0.00564796,0.04129336,-0.05302203,-0.067909,-0.013318317,-0.0013454984,-0.10420696,-0.021552924,0.011720926,0.045718685,0.03414644,-0.048136674,0.039807014,-0.020429736,0.040160786,-0.0574276,-0.06483581,-0.025403375,-0.00038538993,-0.04424946,-0.07023632,-0.03241676,-0.012566157,-0.041902702,0.04936148,0.07228985,0.017984191,0.079061255,-0.026124306,-0.022189027,0.04453399,-0.06129758,-0.020904291,-0.0354022,-0.003991181,-0.015804075,0.0018617786,-0.052165993,-0.0786834,0.10789559,-0.03086692,0.014535392,0.047862418,-0.055704482,0.12120378,0.081347816,0.05105997,-0.04368929,0.01132824,-0.049063794,-0.02561638,-0.009335581,0.013932954,-0.0688969,0.035193965,-0.1046925,0.04566214,0.050760765,-0.005540534,-0.04851464,-0.003132014,-0.06268541,0.106728286,-0.044927593,-0.0058781686,-0.063120075,-0.022326045,0.011220803,0.04685223,-0.008430316,0.051490985,0.027877796,-0.025611984,0.018142078,-0.01521318,0.003339939,0.06544821,-0.054213855,-0.02957775,-0.051293712,0.019700151,-0.0023459,-0.05919596,-0.0030291304,0.047691993,0.050944053,0.03010683,0.006131028,-1.3227627e-33,0.13235176,-0.01835914,0.04822228,-0.013783355,0.012993372,0.018700512,-0.10640057,0.0074909264,-0.0030647996,-0.0071136886,-0.0006390771,-0.08826032,0.06072102,0.07687659,-0.00794631,0.002950327,-0.0027936015,-0.059263237,0.06723578,-0.03058826,0.036320075,0.051889792,-0.04048914,0.047063075,0.004716418,0.0011891661,-0.055423643,0.08992811,0.0024065198,0.010719824,0.03928972,-0.064160794,-0.08797461,0.009625845,0.043013647,0.013615039,-0.11040019,-0.04820106,0.025678491,0.07251249,-0.020175042,0.0485904,0.019075878,-0.027776783,0.07508377,-0.07501857,0.0013304857,0.07232433,-0.043482114,0.0795643,0.07298236,-0.06277208,0.06314696,-0.050566975,-0.034232505,0.01370055,-0.037466772,-0.035684064,-0.005176199,0.10906485,0.016587628,-0.007966114,-0.030045316,0.10494689,-0.06485499,0.045232642,-0.13704623,-0.08311909,0.02785854,-0.011219006,-0.011918732,-0.012674539,0.11464084,0.018187758,0.024429401,-0.01827319,0.057573393,0.03822933,0.06355008,0.026037162,-0.019182047,-0.12218978,-0.008924919,0.021849187,-0.022159372,0.011863779,0.00317106,-0.014018362,-0.016360506,0.009671562,0.10250923,0.008604831,-0.037844,-0.031124609,0.026093537,-1.5609013e-33,0.08294298,-0.028015314,0.027208064,-0.1513789,-0.05437772,0.12186152,0.025821099,-0.0672607,0.047838647,-0.075708136,0.10976871,0.051908586,-0.0364735,-0.01955076,0.035045113,0.047424003,-0.039277703,0.058591034,0.0031990742,0.018919194,0.0021860558,0.1296871,0.0014666861,0.036976185,0.079435624,-0.05844857,-0.08274653,0.021870764,0.033980433,0.054721795,0.009099281,0.024121687,-0.1369886,-0.026383244,0.051402938,0.027460357,-0.04383255,0.017171793,-0.08631448,0.048163358,-0.022989934,0.013521638,-0.022027781,0.017528564,0.098184325,0.027165452,-0.070393935,-0.08901252,-0.057544943,-0.027826212,0.01685297,-0.017244365,-0.05176288,0.002975127,0.034147914,0.09028958,-0.017985797,-0.0043279086,0.06896877,-0.08457843,0.02322334,-0.0047516883,-0.049660478,-0.05131785,0.029384546,0.030095786,-0.002361207,0.05002582,0.08104802,-0.07597624,0.020807562,0.07737543,0.07767438,-0.008458483,-0.052270934,-0.029369501,-0.08541441,-0.03821807,-0.03819842,-0.06644551,-0.06230343,0.044898275,-0.05735708,-0.04910419,-0.092347346,0.0014073993,-0.030610474,-0.03995079,0.009983959,0.0180798,-0.029032473,0.010275419,-0.008791638,0.06274633,0.0049269632,-2.4453998e-08,0.038902618,0.01729394,0.037578855,-0.08498851,0.018539352,0.026352089,0.05408488,-0.033653338,0.027446296,0.003923465,0.06263963,0.12915501,0.052674294,0.04117546,0.050790798,-0.03214034,-0.0032142266,-0.0074199354,-0.06890573,-0.10867682,-0.07185482,-0.03177667,-0.077714205,0.04942109,-0.0023103962,-0.05676759,0.016437883,-0.028706215,0.042448256,-0.064196736,0.019641276,-0.011291165,0.034611925,-0.010302698,-0.01773299,0.040344805,0.031134952,-0.008538563,-0.06909447,0.07572532,-0.050439265,-0.050914068,-0.024633078,0.011291926,0.05627299,0.013580009,0.029383318,-0.0035323233,-0.046082832,-0.014471034,0.021759016,0.012522582,-0.058449376,-0.044925362,-0.07504252,-0.017779933,-0.026679028,-0.040747996,-0.044513877,-0.08708926,0.03434611,0.039389707,0.06218958,-0.0368323 +3.1.2.20,Broad specificity for medium- to long-chain acyl-CoA. Insensitive to NAD+ (cf. EC 3.1.2.19 ADP-dependent medium-chain-acyl-CoA hydrolase),384,1.0,-0.08632766,-0.09070035,-0.013149722,-0.005440124,0.03824735,0.005673552,-0.092712894,-0.003959345,-0.045586213,-0.05063083,0.041608665,-0.019331265,-0.06386934,0.09263277,0.0072535537,0.035190165,-0.047630943,-0.059555534,0.034139518,-0.027463794,-0.009250092,0.04878816,-0.010355929,-0.0108936615,0.015854854,-0.09687921,0.034437176,-0.024520116,-0.054616936,-0.0648974,-0.006173666,0.005720089,-0.004456779,-0.035178453,0.04349383,0.002512341,-0.056260593,-0.03684374,0.017118575,0.044510905,0.07212817,-0.00018050669,0.016042588,0.0059687435,-0.075889505,-0.13718484,-0.04455566,-0.009150435,-0.0090748845,0.06665054,-0.014711359,0.033044837,-0.058746576,0.041243806,0.040430352,0.016059758,-0.010094059,0.011873227,-0.041312065,-0.045793485,-0.022386523,-0.05348439,-0.06223161,0.03436685,0.021328779,-0.009768011,0.106432706,-0.016562447,-0.006380108,-0.009166327,-0.1083725,-0.037646748,-0.030018624,0.017829828,0.08499463,-0.013521678,-0.039502583,-0.08565134,0.058544934,0.013931753,-0.024660036,0.043488443,-0.061748285,0.052370448,0.035733104,-0.034045175,-0.028157724,-0.013187995,0.017551318,-0.028775733,0.02207921,-0.0543606,-0.040507346,0.057868175,-0.079603724,0.055102028,0.095203266,-0.027815806,-0.02598282,-0.078076325,0.009318299,0.07348564,-0.017924115,-0.017122997,-0.03867519,-0.0021377283,0.00015178761,0.14499167,-0.0018389905,0.016555715,0.011106782,-0.00022047578,0.07098263,-0.0718465,-0.004345576,0.039309774,-0.0771679,-0.031077934,0.036732633,-0.044278134,-0.020663207,0.010698162,-0.020010972,0.035004776,0.04316257,0.045483958,-0.037307914,-1.6979364e-33,0.06847424,0.00012221393,-0.0056472337,0.019066032,0.023132065,-0.014270396,-0.09727377,0.029226033,-0.0985981,0.046900317,0.06938073,-0.0032308567,-0.03121587,0.057256732,0.0064502717,-0.019035505,0.027552271,0.0063549126,-0.0054556685,0.043566804,-0.016793137,0.05895244,-0.021572927,0.048847623,0.06097797,-0.05947271,-0.036827106,0.13169886,-0.03247302,0.016420767,0.013892092,-0.026043925,-0.054469638,0.007315508,0.029846534,-0.04477962,-0.098890126,-0.0010384788,0.014180905,0.08044624,0.039423805,0.06950228,0.049832527,-0.059426002,0.016506763,-0.055510487,-0.0004437608,0.097361185,-0.032843616,0.095289476,0.056687616,-0.0032147903,0.1100432,0.011278598,0.032059915,0.06353152,-0.082532495,0.045475762,0.042679094,0.006415524,0.051196806,0.0217468,-0.037006687,0.07662954,-0.070606075,0.06777814,-0.09432426,-0.0182463,0.035153273,0.052330304,0.01569419,0.029783228,0.015960801,0.043255724,0.08361201,-0.075059585,0.004430746,0.05596722,0.05466718,0.05028479,-0.039015457,0.012416076,0.032620143,0.053122506,-0.033110894,-0.013239887,0.00023479383,0.021331025,0.0009062368,0.05443323,0.035036445,0.024417784,0.049991228,-0.005071347,0.064292245,-1.9037638e-34,0.12527965,-0.083224505,0.022278665,-0.18013448,-0.053514022,0.035861354,0.07552767,0.0020747336,0.0240875,-0.06977469,0.107022956,0.11685448,-0.1020598,-0.0839388,0.047575418,0.010381452,-0.0414939,0.054109044,0.052653253,0.015996598,0.042643238,0.012189281,0.013940603,0.027711159,0.06876079,-0.06995162,-0.054669768,0.029825114,-0.0073604602,0.03650543,-0.020127146,-0.023076832,-0.034419633,0.006758623,-0.011106623,0.015839823,-0.043793723,0.030648502,-0.04107177,0.09059675,0.003347036,-0.0054562883,-0.07470039,-0.040560953,0.06041167,0.042347427,-0.033972252,-0.090509325,0.03872551,-0.059629563,-0.018940946,0.010310698,-0.002040983,-0.06543423,0.00032921208,0.06325594,0.000529471,0.015388121,0.09856971,-0.13886002,-0.053225838,0.033052105,0.019605482,-0.058549233,-0.0026732055,0.06873602,0.0021043178,-0.046333883,0.029567186,-0.019031767,0.012537401,0.03012735,0.03348401,0.0011856356,-0.008113781,-0.07786481,-0.09405745,-0.017779373,-0.05808352,0.017478848,0.022083722,0.013500199,-0.04558893,0.018312538,-0.019203728,0.009643833,0.029611696,-0.010765733,-0.049421616,0.029918002,0.024186479,-0.0035863735,-0.008713109,0.027776014,-0.011761339,-3.23404e-08,0.04981321,-0.014515512,-0.025506787,-0.058497347,0.023335611,0.041074853,-0.012976862,-0.04558535,0.057947483,0.03533986,0.007925133,0.148012,0.0828858,0.10652577,-0.022027832,-0.0901487,-0.054166373,-0.05741234,-0.048232097,-0.06664582,-0.09829391,0.035367753,-0.06579064,0.09676841,-0.0117033515,-0.0175689,0.033097178,-0.041283626,0.032559503,-0.026653389,0.021744499,0.015471561,-0.015134657,0.04143905,0.028748307,-0.0053087245,0.033840697,-0.043298043,-0.06418161,0.0896456,0.03103351,-0.07137223,-0.013955307,0.010661575,0.08625805,-0.028233252,0.0025689085,0.012105792,-0.029513383,0.047421694,0.06822962,0.034461137,-0.06221602,-0.055758044,0.039718404,-0.05748007,-0.013589044,-0.05813944,-0.07297636,-0.054773785,0.054342154,0.016820118,0.10860224,-0.0810019 +3.1.2.21,"Acts on the acyl-carrier-protein thioester of C12 and, with a much lower activity, C14 fatty acids. The derivative of oleic acid is hydrolysed very slowly (cf. EC 3.1.2.14, oleoyl-[acyl-carrier-protein] hydrolase).",384,0.99999994,-0.03752967,-0.03972716,-0.031151498,0.03552807,0.095796,0.038010973,-0.047761977,0.072028086,0.009827073,-0.044576388,0.017822163,-0.066886835,-0.10813103,-0.0020731385,0.014780405,0.03401251,0.019062726,0.010056315,-0.06151374,-0.06977804,-0.031339765,0.0007380651,0.0009918737,0.014546686,0.011813435,-0.05160255,0.022569353,9.17615e-05,-0.015487454,-0.07658744,0.010461318,-0.05615251,0.05875386,-0.010065219,0.02925779,0.02020079,-0.04706798,-0.1214612,0.06485481,0.0004371992,0.10836532,-0.04797954,-0.024116741,-0.010262389,-0.03669982,-0.056113634,0.0074991877,0.03909089,0.014075678,0.014177574,-0.04237595,-0.015377347,-0.07793415,0.00042542096,-0.09327463,0.0074097863,-0.019347452,0.0074757203,-0.042997506,0.029948158,-0.008031144,-0.015322838,-0.004561732,0.047523376,-0.051609702,-0.041291572,0.035032842,-0.059685748,0.085647576,-0.022618648,-0.0602839,-0.045317467,0.0468601,0.049352117,0.053008225,-0.020724224,0.005038325,-0.05373808,0.08902764,-0.082712635,-0.0009415714,-0.0069448636,-0.0032360102,0.05324707,0.009498171,-0.055046376,0.04438173,-0.009144179,-0.0010812398,0.0331627,0.09200821,0.013312249,-0.07054035,-0.007449457,-0.066534504,0.023594769,0.08445905,-0.05296482,-0.017864969,0.00789913,-0.017772678,0.04733694,0.0027555192,-0.0706984,-0.102287754,0.06646332,0.008854732,0.0580304,-0.056492623,0.0034267572,-0.0008752881,-0.05527645,0.032278217,0.011780736,-0.0818887,0.032588832,-0.03643413,-0.122510165,0.0036457484,-0.09674969,-0.004925488,-0.071538486,0.10680921,0.07913893,-0.06996741,-0.04412407,-0.056201875,-1.7380215e-33,0.023140486,0.00032840448,-0.049124304,-0.057386044,-0.002506636,-0.0323087,-0.09741178,0.05376185,-0.04400725,0.01643573,0.035029285,-0.012265835,0.016838012,0.044634104,0.046502568,-0.12179958,0.018588848,0.09072761,0.05374755,0.04877185,-0.02148744,0.08714469,0.0003697679,-0.047208592,0.0025484902,0.006118241,-0.03704682,0.020292152,0.0455407,0.0340316,-0.024721766,-0.02828453,-0.03461896,0.05048392,0.053902026,0.05264777,-0.040537436,-0.03300211,0.02647455,0.07293171,0.04071971,0.024849532,0.023802646,-0.06758446,-0.037764713,-0.023891278,-0.042456392,0.10229291,0.016414797,-0.02227387,0.028646033,-0.05491897,0.070817135,-0.00076945673,0.01175817,-7.73299e-05,-0.0878313,-0.0006750524,0.022568583,-0.029663917,0.013228145,0.04182182,-0.05451243,0.04310081,-0.06924798,-0.016021077,-0.10339716,0.010712496,-0.024745349,0.074737586,-0.0009182977,0.0017821268,0.13741288,-0.04707558,0.06272967,0.0010741809,-0.04145907,0.09446636,0.0014487932,0.055934485,0.039748188,-0.028915592,0.015835835,-0.016991455,-0.06544483,0.036119763,-0.023570662,0.05241843,0.008916805,0.036468476,-0.010852958,-0.06613214,0.0031635785,0.054382488,0.038089123,-1.9955702e-34,0.1153323,-0.107577085,0.052504055,-0.032486517,-0.029647207,0.007763601,0.027269734,0.0058416,0.0072179963,0.008581745,0.16075906,-0.021798177,-0.032385558,-0.08530447,0.021639895,0.015961211,-0.0059239464,0.050440986,-0.046783805,-0.011699141,-0.041587047,-0.04583974,-0.03899476,0.06327197,0.06306445,0.030315325,-0.036943816,0.042486038,0.019904606,0.06823645,-0.037782073,0.00066430774,-0.043485686,-0.01582349,0.008562023,0.08599762,-0.031255253,0.003404645,0.00086851843,0.07177478,0.045279194,-0.026221313,0.032692254,-0.008503726,0.10123729,0.06341489,-0.093736656,-0.024680318,0.003146961,-0.05486503,0.07416213,-0.02179927,0.020156058,-0.0062605795,-0.0063576503,0.13930137,0.031853974,-0.037121646,-0.019144913,-0.09932547,-0.027786754,-0.040750884,0.027031632,-0.03618755,-0.0061080195,0.034078132,-0.13826379,0.019129353,0.030598821,0.016319092,0.036977664,-0.0059231436,-0.0017268305,0.052396037,0.020215468,-0.025774902,-0.011363173,-0.0881304,-0.03995357,0.0013990568,0.04035115,-0.016458392,-0.0059957644,-0.09121958,-0.039348803,0.030940233,-0.029774722,0.0071178246,-0.02905775,0.06670715,-0.04241232,-0.0142754745,-0.016436165,0.08428121,0.052434236,-3.6243215e-08,-0.045771748,-0.036320716,0.043905236,0.014688909,-0.031177385,0.045521446,0.007259874,-0.03480117,0.053318966,-0.05921559,-0.067360155,0.09240506,0.031102402,0.010377551,0.02598442,0.024621753,-0.091015816,-0.03916325,0.0014580485,-0.062896624,-0.049057864,-0.020354483,0.010508986,0.013051937,-0.039160464,-0.0027957314,0.033325452,0.009692611,-0.006855046,-0.012859546,0.0040328735,0.02209877,0.009476705,0.039629206,0.08571623,0.04328438,0.003971169,-0.067075275,-0.11538328,0.11543215,0.047980677,0.046450693,-0.08526884,0.023279194,0.10873478,-0.034811337,0.022193553,0.08734451,-0.039295167,-0.0071548754,0.013543323,0.03622571,-0.092286,0.013547513,0.018967215,-0.07143051,-0.030633722,-0.04812025,-0.045620024,-0.0063909204,0.030503703,0.052455306,0.22496153,-0.014800168 +3.1.2.22,"Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.",384,0.99999994,-0.04498099,-0.06783764,-0.001492563,-0.008909278,0.105510846,0.10421647,-0.10681085,0.038466375,-0.003155626,-0.025133958,0.017582413,-0.040519655,-0.050220158,-0.048314765,0.014940361,-0.039222963,0.04931792,0.021584526,-0.028266659,-0.042445954,0.067916915,0.04731684,-0.08876457,0.037515447,-0.0031786489,-0.01390904,0.036003612,-0.037715025,-0.05963441,-0.022996498,-0.048187595,-0.06514863,0.058591004,-0.03996817,0.039165415,0.058142744,-0.038119145,-0.049542848,0.06568709,-0.042494427,0.07015638,-0.038028736,0.020278217,-0.015255068,-0.07335185,-0.029067464,0.050545406,0.04617781,-0.006922827,0.070872076,-0.014421137,-0.06512384,-0.026671762,-0.00024428617,-0.058757443,-0.018391915,0.021266678,0.035633087,-0.11861315,0.07448937,0.012378353,-0.004523244,-0.026015546,0.02342295,-0.023545327,-0.03131059,0.04001071,0.013282472,0.047911867,-0.026789285,-0.028360408,-0.022042945,-0.011014133,0.08063014,-0.010411533,0.075772904,-0.016864752,-0.05724877,0.0386763,-0.10128544,0.017282976,-0.011685558,0.0058297743,0.0654587,0.039900593,-0.041524384,-0.029136334,0.042364083,0.0013318363,0.01841838,0.1025531,-0.020215204,-0.021878708,-0.033165734,-0.058977462,0.019043187,0.03817677,-0.010840075,0.036512002,-0.065417826,0.040009294,0.053757533,0.006822772,-0.061460394,-0.049419824,0.06034864,-0.08323711,-0.0003045184,-0.03965864,0.00087417016,-0.0153455315,0.014093877,0.07080311,-0.018690785,-0.04360835,-0.014380437,0.0041538696,-0.063058466,-0.03848207,0.007728441,-0.032553174,-0.02887912,0.106961176,0.09706489,-0.027958786,-0.039327297,-0.029959563,2.6630131e-34,0.018854572,0.017062044,0.037092574,-0.04374131,0.018150678,-0.07194737,-0.03395342,0.0741354,-0.024959626,0.07801717,0.027037336,-0.01806984,-0.017321447,-0.019916814,0.00604158,-0.044487152,0.036870267,0.001967029,0.052318886,-0.01873229,-0.05455532,0.0690626,-0.006636462,-0.037067045,0.0061758147,0.0070085595,0.026436932,0.02461256,0.020955034,0.01890383,-0.036094755,-0.05714037,-0.028159708,0.009630061,0.037848428,-0.0015527264,-0.023620855,-0.021183662,-0.03197444,0.06308063,0.069741264,-0.014788279,0.04428965,-0.07588253,-0.074671105,-0.030563219,-0.027120236,0.048705496,-0.02802132,-0.05459849,0.048321135,-0.05929327,0.050651472,0.0009773457,-0.02732399,-0.022904176,-0.041066628,0.042173676,-0.028060665,0.008913851,0.0363064,0.052750874,-0.06097043,0.038077936,-0.07097492,-0.019516105,-0.119568914,0.020201797,0.0042988444,0.092331246,0.042261943,0.0062880903,0.14496765,0.004179858,0.025457839,-0.02704849,-0.0655746,0.089710824,0.031874515,0.048946172,0.029358186,-0.0050060404,-0.005566442,0.013840337,-0.07269903,-0.002036555,0.03341807,0.05256542,0.024184477,0.031242996,-0.019340856,-0.06337799,0.052773293,0.06285454,-0.028785907,-2.3510906e-33,0.080033876,-0.049529735,0.087850705,-0.081472896,0.0167292,0.010815462,-0.015341852,0.06557163,0.002654648,-0.043422647,0.1100464,-0.06229959,-0.020014163,-0.078782864,0.004562226,0.04230206,0.00038998653,0.0033501026,-0.034102898,-0.078535974,-0.02805322,-0.095212735,0.05959292,0.08987882,0.034475066,0.008169575,-0.01090604,0.053246446,-0.0049985806,0.1229252,0.016859489,-0.010771132,-0.022986282,-0.0292914,-0.05942064,0.009841879,-0.079632424,0.027849063,0.027721383,0.07938631,0.0128936535,-0.013760845,0.052265383,0.01969801,0.030986192,0.0059208106,-0.123955175,-0.0651874,0.034563333,-0.1283025,0.03741394,-0.015259094,-0.009513444,0.023973303,-0.002655423,0.13195427,-0.038511027,0.04870449,0.063918546,-0.07481075,-0.061677553,-0.0519939,-0.038541142,-0.08967768,0.03187153,0.022547146,-0.0813586,-0.04060878,0.028354457,0.07216797,0.0496319,0.025768282,0.012445626,0.08264948,0.03651965,-0.029464643,-0.04147693,-0.044200856,-0.03732048,-0.021584453,0.05300838,-0.045451105,-0.066512555,-0.034392316,0.013498665,-0.010673912,0.010622014,0.07171494,-0.00845481,-0.011482324,-0.037878655,0.018639492,0.00016268725,0.10184009,0.0685406,-2.6794229e-08,0.04756603,-0.10174597,-0.027421296,0.0008812094,-0.08295972,0.08599544,0.041952476,0.01671277,0.044726945,-0.054366544,-0.044510085,0.045234874,-0.00022882767,0.033709764,-0.00981859,-0.029916944,-0.08105507,-0.0069333757,0.012552269,0.0039354195,-0.02889609,0.031813137,-0.062331967,-0.005412071,-0.06658291,0.045480046,0.030869592,-0.019287968,0.006738491,0.090795964,-0.015730726,0.012564495,-0.049490914,0.02773712,0.06713922,0.05141531,-0.0127137415,-0.07690345,-0.06614772,0.08193943,0.018218588,0.016875358,-0.12514284,0.020042814,0.07929824,-0.08367887,-0.006271605,0.16391759,-0.034340464,0.040853325,-0.039288767,0.04227341,-0.08921887,-0.03258586,0.020345563,-0.07741956,0.040656783,-0.07512572,-0.06730958,-0.03138159,0.0523264,-0.045594126,0.19047211,-0.0046214988 +3.1.2.23,"This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.",384,0.99999994,-0.0058046444,-0.009891916,-0.031683933,-0.024700478,0.11044303,-0.04973745,-0.0213458,0.04716607,0.00013215136,-0.009158998,-0.03852185,-0.045305196,-0.031857926,0.09581626,-0.046795905,0.12887347,-0.06972082,0.00557061,-0.02025004,0.01123835,0.049004357,0.03971406,-0.055781633,-0.033361334,0.009829424,0.05531273,0.10814282,-0.00919186,-0.034005135,-0.09484287,0.04554109,0.0038761795,0.10286492,-0.027018934,0.069768615,0.106394425,0.017317224,-0.08272405,0.07688094,0.017825527,-0.0029625886,0.093349315,-0.0154979965,0.012861011,-0.035129726,0.05200003,-0.013527415,0.029083902,0.056317028,-0.014325878,-0.06993104,0.021361208,-0.015028083,0.02420062,0.05328379,0.021548739,0.020241011,0.024088496,-0.08337838,0.02340065,0.07824181,0.010477408,-0.0031618818,-0.0044229017,-0.03419374,-0.018480012,0.064394414,-0.04040316,0.032802746,-0.06744554,-0.11237344,-0.0508079,0.0047257384,-0.013053927,0.006724303,-0.0013036616,0.035086185,-0.005648084,0.022341484,-0.07448038,0.032267507,-0.017354028,0.08732708,-0.0016045782,0.017896611,-0.031672053,0.004700762,-0.11741975,0.06211446,0.044496026,-0.0059750285,0.029312046,0.01874299,-0.06277183,-0.029600412,0.06435214,-0.04729549,0.00025480386,0.048182387,-0.003481748,-0.03727258,-0.01926768,-0.03727074,-0.07032829,-0.07897857,-0.028236963,0.051734608,0.10944206,0.02828185,0.019530464,0.042881332,0.066962905,0.1023131,0.04543651,0.040380035,0.057226222,0.064288795,0.0056992224,-0.036780566,0.07774697,0.007384971,-0.045565464,0.055885278,0.005873172,-0.11207888,0.02854522,-0.09577304,-8.751468e-34,0.034077346,0.0062477067,-0.008625536,-0.012722922,-0.0134630725,-0.00436492,-0.067049965,-0.0100798765,-0.061587468,-0.12144035,0.021870365,-0.12004144,-0.0052321544,-0.02710191,-0.0044962065,-0.061384458,0.01751638,0.062200066,0.044117887,0.010789084,-0.023877483,0.04936254,-0.05812457,-0.023757668,0.062170453,0.07584888,0.04977951,0.023265727,0.064084165,-0.012335003,-0.00058284774,-0.022134878,-0.117473684,-0.014067625,0.048114084,-0.0032067653,-0.033040553,0.002293312,0.008026179,0.022577494,-0.0050287717,-0.01430142,-0.028680524,-0.03488409,0.0556752,-0.065358356,-0.028390765,0.08397674,0.05153025,0.04724685,-0.016880674,-0.06673141,0.081882186,-0.053554166,-0.045107353,0.015616536,-0.01238313,-0.036666423,0.058165696,-0.033220537,0.014284954,0.111238904,-0.119135,0.017979998,0.027558375,-0.077947274,-0.0043024267,-0.04215599,0.0064759785,0.08650879,-0.055226587,-0.05620543,0.054273274,0.052784156,0.0067636454,-0.09389629,-0.06677535,0.0013321615,0.09566055,-0.0131359855,0.0010985058,0.0034303702,0.01634681,-0.04893235,-0.08011573,0.019371869,-0.010768145,-0.060065776,-0.01946982,0.042662982,0.045479115,-0.07812861,-0.097162634,0.036601964,0.0086948415,8.0543363e-35,0.0779046,-0.05596653,0.037934233,0.020402353,-0.06818932,0.023378,-0.020648472,0.033694185,0.016228369,0.008135288,0.044348877,-0.011434719,-0.027673256,-0.032821976,0.017119428,0.058929987,0.052608296,0.028343843,-0.05134207,-0.041776147,0.06559317,0.07488701,0.011768299,-0.004030659,-0.0095194625,0.028960655,0.021067923,0.08689701,0.06140374,0.04167205,-0.07320952,0.0793689,0.0045561288,-0.023306537,-0.07317175,-0.0098676495,-0.097296216,-0.05351112,-0.026728582,-0.021581937,-0.04709543,0.021865208,-0.0057375547,0.011315229,0.0027381352,0.05900432,-0.018969664,0.043923847,0.052616827,-0.05315818,-0.013681957,-0.016361706,-0.03539765,0.040980313,-0.044217344,-0.00788966,0.0003313355,0.008047772,-0.023075022,-0.0022086187,-0.033873443,-0.029913502,0.07741048,0.046917956,0.08671167,0.065866485,0.004295098,0.0974387,0.028719047,-0.03520749,0.044555735,0.010758729,0.0431964,0.031603057,-0.06220928,-0.0030855834,-0.11839239,-0.0006965096,-0.018736241,0.004143158,-0.011352185,-0.00127685,-0.021548895,-0.06808137,-0.063333645,-0.13079467,-0.0127476705,0.10509864,-0.025357997,0.05565426,-0.025927963,-0.028582057,-0.0588057,0.05849696,0.05132546,-2.2684597e-08,-0.020154255,-0.053599678,0.06472149,-0.04165736,-0.0125202,0.044549588,0.0269744,0.08141492,0.08596833,-0.028714243,-0.07782884,0.055677876,-0.014519503,0.028621936,0.019792585,0.07941676,-0.033222347,-0.090868674,-0.0021860462,0.005399599,-0.04128529,-0.048013303,-0.07300615,0.021523256,0.007661091,-0.046037253,0.009033099,0.042829968,-0.008552786,-0.043838102,-0.016255265,0.067481145,0.035323754,-0.05692552,-0.11722355,0.0017043425,-0.019886665,-0.0775511,-0.030421333,0.07260711,0.042004336,0.055646174,-0.0701147,0.014033261,0.036744837,-0.00017122459,-0.008518911,0.009228731,-0.019340865,-0.09332308,0.044770356,0.0059191016,-0.043437544,0.015924301,-0.10371881,0.023250358,0.019295538,-0.036259696,-0.011328393,-0.039626747,-0.0065456186,-0.01738952,0.18522285,-0.051564243 +3.1.2.25,"This is the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, phenylacetyl-CoA dehydrogenase.",384,1.0,-0.10877777,0.02554181,0.0006060148,-0.04051652,0.08896348,-0.0028783511,-0.081259884,-0.037445005,-0.031294867,-0.00029720383,0.079202466,-0.061640706,-0.027105713,-0.033357363,-0.031406473,-0.011919151,-0.09911337,0.05397052,-0.045175813,-0.026208038,0.02547558,0.03289324,0.0016923582,-0.015295978,0.09756433,-0.026689505,0.031368516,0.018718334,0.017122373,-0.045207545,0.11826663,-0.018165777,0.017561391,-0.017876916,-0.03008519,0.03394847,0.025026856,-0.06977309,0.02539277,0.05559244,0.058105472,-0.0903208,-0.061119065,-0.070577204,-0.058368348,-0.060009256,-0.009891886,0.017275497,0.035121553,-0.028818734,-0.0009428114,-0.0020742938,-0.08343277,0.011039867,-0.00019389718,0.08972461,-0.025184905,-0.008069027,-0.021591647,-0.0126710525,-0.05092088,0.0025392412,-0.030125508,0.04560937,-0.008582184,-0.09689126,0.05061122,-0.09655711,0.05229926,-0.06947982,-0.08250173,-0.07362021,0.022140885,-0.01616075,-0.018648202,0.008547115,-0.010275742,-0.023153905,0.04302388,-0.05342142,0.023886923,-0.0043824557,0.0071656387,0.027728792,-0.054991405,-0.011554611,-0.012482454,-0.016758831,0.0059618293,0.01711805,0.031768933,-0.03687458,-0.009135974,0.06846526,0.030535253,0.08774811,0.035084285,0.032089505,0.081650846,-0.0028927908,-0.049959254,0.081801206,0.042700432,-0.09307976,-0.057068195,-0.111177646,0.004289446,0.11265201,0.010703068,-0.010167685,0.055564035,-0.051922962,0.1059363,-0.0027577325,0.054206733,0.13366811,-0.026617553,-0.03082428,0.023060312,-0.0035151513,0.014469594,-0.0009023482,0.05947287,0.06401835,-0.025971035,0.035500724,-0.023089824,1.727129e-33,0.065715715,0.061241135,0.038057454,0.04285313,-0.080445565,0.013868814,-0.11479726,0.060278043,-0.0254171,-0.056081597,-0.029687082,-0.06771199,0.014205093,0.05051557,-0.09187866,-0.10484417,-0.031482738,0.007847238,0.07701772,0.04411948,-0.011105303,0.021904122,-0.037055355,0.057049308,0.014039384,0.023594595,-0.06339174,0.06505615,0.05271623,0.007831794,-0.011584338,-0.10097024,-0.076450355,-0.033192586,-0.03665688,-0.001893245,-0.015797257,-0.039625578,-0.03723994,0.079304636,0.021784846,-0.008426997,0.010934127,-0.038097832,0.03659108,0.04497537,-0.0409544,0.06641627,0.07118146,0.06387675,0.010748513,0.03311228,0.103087656,-0.016086074,-0.04758415,0.024571942,-0.030717628,-0.066100776,0.047529057,0.022644313,0.03379936,0.1256351,-0.006917201,0.07105692,0.03130328,-0.012218151,-0.04004315,-0.057112765,-0.013851711,-0.003725458,-0.07716303,-0.0065548895,0.067909144,-0.007736022,0.14627975,0.00043564226,0.010045572,-0.019363228,0.06634275,-0.03986086,-0.057333685,0.07975176,-0.056296766,-0.038481127,0.0361229,0.0392122,-0.051597815,-0.05394588,0.028479686,0.082483985,0.0077468734,-0.13095091,-0.015473487,0.022604654,0.037533175,-2.7227843e-33,0.10497175,-0.06434804,-0.015243035,-0.053855665,0.005609211,0.039891515,0.053009808,-0.011047537,0.056108136,0.025755955,0.09207236,-0.021563465,0.025808372,-0.06000935,0.035938945,0.020557398,0.008981739,0.0255761,-0.014472733,0.08116154,0.055216394,0.0023430486,0.037791286,0.06482349,0.083801754,0.009847635,0.060941305,0.025688842,0.045886632,0.03794935,-0.06790086,-0.01766018,-0.04455684,0.05388718,-0.09283113,0.07436442,-0.0544273,0.02408183,0.0056810733,-0.04080397,-0.058702916,0.00012514136,-0.029152023,-0.0068641016,-0.0030966075,0.045647666,0.005424776,0.01470604,-0.021952963,-0.11149065,-0.039974485,0.1103134,-0.04295217,0.010672733,-0.02985752,0.084586285,0.006680455,0.048787743,0.047023322,-0.08898681,-0.05931804,-0.07524144,0.03479473,-0.047776725,0.026029738,0.01786616,-0.040179715,0.08851218,0.03048613,-0.04682179,0.00901392,-0.031965274,0.09941908,0.028371181,0.017996693,-0.09305218,0.0073931315,-0.07583973,-0.036232032,-0.0735556,0.005951318,-0.06903466,0.0007126353,-0.07397141,-0.030572627,-0.08070796,0.026061654,-0.01830114,-0.022086857,-0.011962589,-0.06473459,0.034382105,-0.053421397,0.060846306,0.027120216,-3.0188e-08,-0.038053807,-0.09839569,0.036577895,-0.011443729,0.09842773,0.07992005,0.021186775,0.0066830777,-0.01634055,-0.053480413,0.015831977,0.102747016,0.053493902,0.02868182,0.007062091,0.011235101,-0.07284675,0.018780572,0.015575095,-0.08397619,-0.06486319,-0.025248667,-0.05204565,0.044674486,0.0035121148,-0.013843354,0.041404426,0.030752482,0.016233161,-0.055837657,-0.013787593,0.033808745,-0.034192182,0.045975164,0.03246707,0.011206436,-0.009701961,0.021444319,0.0065290146,0.03711506,-0.0070760194,-0.026645737,-0.03819642,0.028363548,0.014922649,0.013085196,-0.034287646,0.06921659,-0.013142287,-0.03676917,0.045545112,-0.019944165,-0.0023090704,-0.026345653,-0.035767812,-0.0031689603,-0.051109143,-0.09560793,-0.03583673,0.017981144,-0.03775146,0.08783396,0.13081302,-0.0414554 +3.1.2.26,"Choloyl-CoA, 3-dehydrocholoyl-CoA and chenodeoxycholoyl-CoA can also act as substrates, but acetyl-CoA, isovaleryl-CoA, palmitoyl-CoA and phenylacetyl-CoA cannot.",384,1.0,-0.0654798,-0.20692517,-0.03253632,-0.077526085,0.036180705,0.013666023,-0.074537784,-0.0418808,-0.05052587,-0.04269654,0.10121312,-0.07744519,-0.06796231,0.08908913,0.054075714,0.01508384,-0.032209143,0.018958006,0.06552408,0.06882294,0.047125306,-0.051076673,-0.051103733,-0.013203947,0.05303494,0.03111455,0.0076302127,-0.0181545,0.03142062,-0.10509163,0.019224629,0.03421943,0.062139798,-0.04157524,0.06700277,-0.0062970533,-0.06436879,-0.018975647,0.028832097,0.048587523,0.021156877,-0.09631729,-0.0055684065,-0.03504725,-0.029987752,-0.13346171,0.009361046,-0.03465311,-0.012209263,-0.004400671,-0.005001427,0.024713205,-0.06817645,0.05638533,-0.058672562,0.039069843,0.0131485835,0.016195115,-0.019371774,0.030802103,-0.02908922,0.024857609,-0.047427375,-0.018505588,-0.011466848,0.036949743,0.020609437,-0.006359879,0.046364505,0.045576222,-0.014306847,-0.0816795,-0.010271598,0.057004217,0.06627277,0.04768462,0.010526921,-0.049414404,0.061706424,-0.028490717,-0.12121837,0.009472907,0.011468906,0.070021324,0.03291092,0.008324768,-0.05509342,-0.014142813,-0.08439203,-0.05657529,-0.055747066,0.016795091,0.0010410887,-0.009003644,-0.04040054,0.036813486,0.09201714,-0.00949762,0.024356864,0.025868054,0.04426818,0.06912346,-0.08488165,-0.09091844,-0.023303676,-0.006841159,-0.039311923,-0.019088041,-0.01848941,0.00018503843,-0.054001372,-0.009260609,0.037464928,-0.074268535,-0.051293,0.0022283704,-0.008326278,-0.047109593,0.047921274,0.04293097,-0.037493862,0.027592264,0.06029566,0.048162635,0.04127906,-0.0005492835,0.06744588,3.6685816e-33,0.055117663,-0.032669004,0.06840612,-0.010137071,-0.024498755,-0.03929911,-0.046293892,0.013940494,-0.029517846,-0.041947182,0.06723313,0.02873117,0.015318686,0.0782311,0.08880467,0.08006825,-0.02316024,-0.011548864,0.06292257,0.006396975,-0.03403941,0.05504009,-0.048009194,0.040561747,0.008521253,-0.019546656,-0.05331501,0.063689254,0.023518596,0.039342828,0.011150516,-0.014588961,-0.003199171,0.009018363,-0.03123879,0.02657042,-0.13154769,-0.018179828,-0.03694132,0.046268858,0.08742489,-0.030673897,0.0018288437,-0.0023184477,0.0035161553,0.0028335904,0.050111108,0.018222993,-0.10278755,-0.026260504,0.04973648,-0.014564393,0.029225465,0.0044930545,0.027016725,0.03200871,-0.0285992,-0.037051164,0.026921574,0.0046497243,0.018430756,0.054494917,-0.051871624,0.0508938,-0.003649719,0.014699357,-0.061759487,-0.013308316,-0.06597023,-0.0064094486,0.0036289243,-0.014077116,-0.006775346,0.05670779,0.042001843,-0.024114817,-0.01729345,0.021530705,0.04855246,-0.0014913284,-0.018008454,-0.035447057,0.0053160363,-0.066605926,-0.11425627,0.010349462,0.016525276,-0.03493134,-0.012850114,0.038395837,-0.024381325,-0.054376017,0.027026452,0.004223604,-0.0013600248,-5.555756e-33,0.053333562,-0.07764358,-0.01949054,-0.13230567,-0.09111396,0.05279077,0.06981771,-0.028751148,0.05809673,0.010219163,0.0498478,-0.003281567,-0.022568485,-0.08021662,-0.002702093,0.066567086,0.034924835,0.029722018,0.018816022,0.015672358,0.0051104194,0.08720591,0.015950482,0.10862223,0.04859456,0.0013599745,0.023409436,-0.0074966894,0.028987573,0.11633309,0.033750758,-0.0009959263,0.046739645,0.0031750756,-0.021164235,0.01275647,-0.046531484,-0.0027225132,-0.07171255,-0.062134977,-0.042011686,0.042056452,0.054390855,0.014591262,0.042598948,0.013702215,-0.039061002,-0.068744026,-0.032381628,-0.02388669,-0.017744688,-0.010179615,-0.06348061,-0.055272836,0.02167598,0.119017646,-0.0481722,-0.042148847,0.07434503,-0.09131675,-0.0516547,0.03476183,-0.022540446,-0.07868097,0.1002761,0.085844666,-0.051075883,0.06354564,0.024847468,-0.070484966,0.10054683,0.08450515,0.08084152,0.03924251,-0.0055824593,-0.041400023,-0.061935488,0.026640497,-0.097772,-0.05540706,0.035950948,-0.025790721,-0.030984355,0.023236863,-0.09467286,-0.029748287,-0.021614954,0.003884264,0.011302128,0.03315927,-0.0112833325,0.016919177,-0.02786846,0.10398754,0.068515815,-4.2741405e-08,0.0856939,-0.044075392,-0.001214412,-0.06409978,-0.091121376,-0.019586243,0.04271041,-0.0679017,0.051848132,0.024107583,-0.021058884,0.09297451,0.006084025,0.046825267,0.017175265,-0.003261522,-0.007909218,0.0019233437,-0.024666063,-0.0710435,-0.07751326,0.02828788,0.011758411,0.10954054,-0.05782085,0.015774494,0.051923722,-0.007347648,0.03531754,0.02554452,0.016598238,0.011771029,-0.05984693,0.04727794,0.054990347,-0.02548257,0.010972016,-0.103040524,-0.050537754,0.12087093,0.0077931685,-0.030951237,-0.06658704,0.013687525,0.09996951,-0.024464322,-0.044388898,0.040815365,0.02486572,-0.034753207,-0.03594467,0.031899713,-0.06352711,-0.03539733,-0.04118348,-0.013586982,0.0036160438,-0.06824733,-0.03049314,-0.022490088,0.037422758,-0.015690925,0.20715518,0.036988877 +3.1.2.27,"Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1].",384,1.0,-0.05702765,-0.07637208,-0.0026172053,-0.05178725,0.06150392,0.062995926,-0.118560255,0.029498354,0.018799623,-0.05032093,0.048863575,-0.007510125,0.0031823143,0.052853297,-0.05518382,0.092607096,-0.050045796,-0.009651458,0.07242112,-0.01201055,-0.0039819856,-0.006776169,-0.046559874,-0.02119193,0.049803033,-0.034521885,0.032678317,-0.046339877,0.038808364,-0.06304097,-0.0059057623,-0.00470504,0.06481606,0.009355897,0.030043941,0.072451286,-0.068975724,-0.06483348,-0.036755454,0.040222652,0.026022425,-0.06463899,-0.057772197,-0.038871158,-0.0568447,-0.09673393,0.046386182,-0.0008610103,-0.017469866,0.06285915,-0.0087955315,-0.049347613,-0.069983095,0.06298212,-0.020872535,0.024358107,0.038357943,-0.0096404115,-0.061083432,0.0012686575,-0.006442926,-0.014814431,-0.044396393,0.023877036,-0.0087488275,0.037919253,0.043316428,0.04628414,0.008573904,-0.09225048,0.023501653,-0.048072528,-0.013934737,-0.019293718,0.04233274,-0.019509152,-0.029073523,-0.10561885,0.04786008,-0.033952102,-0.11021827,0.011418938,0.02835415,0.061233852,0.023749873,0.023161184,0.003457329,-0.018527064,-0.027129164,-0.026367621,0.011739482,-0.012335935,-0.06350369,0.01014925,-0.01952307,0.11271309,0.05205305,-0.0080162715,-0.0104197655,-0.06201222,0.062246725,0.03264773,-0.10567894,-0.06896693,-0.017508708,0.02440864,-0.015390136,0.0036461188,0.042869978,-0.003577663,0.00030889743,0.039466854,0.045795992,0.01618374,-0.012965683,0.030591067,0.07893255,0.030391535,-0.026479002,0.044612434,-0.021984797,-0.008668475,0.034082882,0.032419797,0.024432933,-0.002757126,-0.0047372645,1.882508e-33,0.0548335,-0.0093294615,-0.020053254,0.02984698,0.02197806,0.014761589,-0.10268339,0.019392742,-0.071265206,-0.00069694716,-0.009290216,0.025379822,-0.021915603,0.037720457,-0.0030052443,-0.029918252,0.046893794,-0.019444626,0.055248674,-0.011650619,0.044882268,0.019400386,-0.043528765,0.041977532,-0.023586467,0.0428508,0.0037862165,0.09675182,-0.0018034576,0.0042644297,-0.042656522,-0.034174755,-0.05442767,-0.023208668,0.012934123,0.023913965,-0.103328414,0.033375863,-0.069772795,0.11112619,0.0656503,-0.0063098953,-0.054671347,-0.07909776,0.10493625,-0.09634371,-0.029806051,0.14852439,-0.021251155,0.056565683,0.06991613,-0.011204948,0.038469758,-0.016659578,-0.039620373,0.016965333,-0.05256842,-0.055472847,0.0016904528,-0.0038312685,0.054512057,0.027767675,-0.025137778,0.023833552,-0.008102847,-0.0030775026,-0.04681353,0.035178736,-0.045549512,0.026612917,-0.040450495,0.022398682,-0.014839594,0.06532312,0.024588961,-0.07234543,-0.05936096,0.049960013,0.11960761,0.0029989246,-0.037151836,-0.011313955,0.07131502,-0.042898856,-0.05348801,-0.030434836,0.0063873166,-0.027813949,-0.019439941,0.04548162,0.08168119,-0.045564555,-0.032224633,0.05510684,0.012980851,-4.2462625e-33,0.0665667,-0.15240812,0.02471278,-0.1901794,-0.011677747,0.032021664,0.061244637,0.080383964,0.04642919,-0.02204442,0.07894978,0.025551872,-0.07577476,-0.05412133,0.04347603,0.064056344,0.046636615,0.046950653,-0.047210746,0.034064647,-0.04588704,0.028578319,0.0411625,0.083267555,0.017784785,-0.004418005,0.020072762,0.0016583992,0.012486206,0.08787315,0.023135554,-0.023519922,-0.009557559,0.0025585603,-0.01127365,0.031281635,-0.0854662,0.042242005,-0.0037728534,-0.04413408,0.041717086,0.018395303,-0.027459152,0.012037578,0.029063558,0.033779513,-0.12394452,-0.116030835,-0.04820078,-0.07870649,-0.010488622,0.010699713,0.042824622,0.008869998,0.014361934,0.02190649,-0.07252197,-0.026411358,0.086475424,-0.103246234,-0.095923044,-0.004240627,-0.036519974,0.019760087,0.044082586,0.037810374,-0.034157284,0.031723563,0.03237539,-0.020318355,0.098281614,0.060870785,-0.0036309774,-0.014808242,-0.07947177,-0.010206241,-0.02013413,-0.03942078,-0.01789325,-0.044571344,-0.011611046,0.025385944,-0.06501774,-0.07390829,-0.13829257,-0.089240246,0.00711126,0.07498825,0.04507936,0.02047499,-0.017493537,0.05628305,-0.061921272,0.016087806,0.11152757,-4.284059e-08,-0.045928724,-0.06503096,0.030632813,-0.027402094,-0.018928036,0.01093444,0.031854656,0.00371442,0.029106854,0.005174161,0.023592059,0.12687652,0.0488979,-0.02064895,0.015533462,-0.022102132,0.011354551,0.009898239,0.006161469,-0.057461437,-0.11937794,0.040597606,0.007936255,0.059097618,-0.061109815,-0.020523673,0.05209433,0.0019338988,0.021417532,0.004289445,0.0022893879,0.041707974,-0.043655258,-0.01244331,-0.00950631,0.050665304,0.08677349,-0.0016722995,-0.03230556,0.0888429,0.06016327,-0.08159733,-0.017077021,-0.013875114,0.072099194,-0.044159997,0.0006023702,0.03697263,0.056546997,0.014071367,0.04318485,-0.0003985532,-0.05894922,-0.038128316,-0.0741669,-0.026787532,-0.00017730577,-0.08335015,-0.06456936,-0.06335496,-0.036376514,-0.022196706,0.2065007,-0.017737431 +3.1.3.1,Wide specificity. Also catalyses transphosphorylations. The human placental enzyme is a zinc protein. Some enzymes hydrolyse diphosphate (cf. EC 3.6.1.1 inorganic diphosphatase),384,1.0,-0.03768581,-0.017508877,-0.041591417,-0.0014220836,0.059493434,0.009118857,0.008631818,0.068101674,-0.019532094,-0.02374341,-0.043293506,-0.03137469,-0.09155281,0.062286172,0.001050771,0.02401624,-0.010904888,0.008019917,0.022279628,-0.039643895,0.043474592,0.02724895,0.004896079,-0.0455777,0.041412733,-0.023878766,0.0014924642,-0.0014697944,0.04131497,0.0010369045,-0.0899241,-0.026035547,0.027913352,-0.056727033,0.022877946,0.10697384,-0.027116263,-0.008713529,-0.014779831,0.023179665,0.116461545,0.036191,-0.018272039,-0.05146061,-0.0067499387,0.03086787,0.062950216,-0.055994537,-0.03906199,0.06593171,-0.060905106,-0.031794615,-0.05713738,0.07901322,-0.019363638,-0.03837043,-0.06039053,0.0075176856,-0.014307191,-0.03506407,0.002031947,-0.01863857,0.009317162,-0.015049275,0.18898575,-0.026066668,-0.006761824,-0.008683524,0.012306083,-0.06876118,-0.0075147534,-0.01798817,0.013965611,0.0893423,-0.007966866,0.064359546,0.0027504312,-0.042777143,0.02353542,-0.06447666,0.015135289,0.013841097,0.017610757,0.09922363,0.0034317765,0.071233526,-0.053498253,0.08895036,-0.04772175,0.026085509,-0.011793685,-0.028200815,-0.0014616495,-0.025160177,-0.073965736,0.028663406,-0.009538813,-0.0056356615,0.03859028,-0.02437914,0.028067235,0.08878115,0.056448475,-0.014019192,0.0054546553,0.055579044,-0.019056957,0.08491665,-0.012170534,0.017270649,-0.04975563,-0.0022955432,0.020686239,0.009173084,-0.010875179,-0.0067282026,-0.011855742,-0.044497013,-0.034113128,-0.03614463,-0.011004583,0.032034017,0.004895045,0.08408307,-0.01754793,0.07047785,-0.12347452,1.5733248e-33,0.0063352766,-0.0034330834,0.101869635,-0.010271959,-0.04500919,0.08012561,-0.034730792,0.047350608,0.01691761,0.02661054,-0.03492744,-0.08387119,0.08049432,-0.0024480075,-0.031984907,-0.052283604,-0.0007294053,-0.008688617,0.09984536,0.07676094,0.08663553,0.04044902,-0.12532046,-0.034258757,0.05629559,-0.005057168,-0.018046547,0.0021952293,-0.032845505,-0.043919705,-0.015358181,-0.053928725,-0.04895519,-0.040073175,0.110945225,-0.05964484,-0.022452286,-0.05824359,-0.010550851,0.016621714,-0.05061476,-0.09832601,-0.043789856,-0.006349739,0.068273604,-0.050202694,-0.058265124,0.056832552,0.01745327,-0.02430438,0.06558018,0.0066204946,0.043643907,-0.058289,-0.07794159,0.066478856,-0.06947575,0.008623863,0.009451915,0.07282618,0.03263857,0.019338807,-0.059283797,0.021687828,-0.0063334145,-0.051145162,-0.062864766,-0.04630578,0.01320834,0.1416655,-0.084572226,-0.013374155,0.061707754,-0.024811834,0.0018662472,-0.03590744,0.0065563726,-0.0008583362,0.03735472,0.0035049168,-0.030511085,-0.05917627,0.018124277,0.006617065,-0.058085017,-0.04826555,0.021394325,-0.059190568,-0.054053176,0.041475363,0.020963237,-0.061693702,-0.035557806,-0.010412998,-0.03979483,-2.8846832e-33,0.0006650488,-0.04847422,-0.028961113,-0.1016145,-0.014009132,-0.049348146,0.060962424,-0.036873586,0.027524127,0.019298565,0.061809,-0.011946235,0.09043906,-0.07566764,-0.019457672,0.056427762,-0.100128576,0.09785211,0.12997642,-0.003919495,-0.05087542,0.086928405,-0.016428223,0.056293387,0.08076197,0.013759994,-0.041587353,0.046430465,0.0453242,0.08124785,-0.06443916,0.06742308,-0.021149816,-0.08319923,-0.015301427,0.0076806336,-0.050222848,-0.043452177,0.07335854,-0.021681877,-0.020337727,0.010185581,0.009926009,0.08185808,0.0066727,0.11198871,-0.10433318,0.03420966,-0.034923613,0.0034151147,0.010368823,0.043490626,-0.08085386,-0.002877106,0.026188647,0.0659211,0.049538683,-0.060313873,0.073380224,-0.019987145,-0.00788226,-0.06708535,0.024865478,0.047627375,0.006041744,0.03084921,-0.011271112,-0.012683451,-0.05222933,0.021750804,0.07896527,0.024759406,0.0038397661,-0.0045948355,-0.0009032978,-0.06471559,0.0188433,0.010370831,0.016897209,-0.016554577,0.025130495,0.029140415,-0.016248662,-0.01034684,0.015487304,-0.03158112,0.0026206456,0.1475659,-0.049484782,0.007237256,-0.09507059,-0.04353653,-0.10767292,0.040330824,-0.031458292,-3.1828556e-08,0.027178025,-0.026631987,0.062145118,-0.052081868,-0.038938545,0.0052939346,0.030292327,-0.018828174,-0.009090808,0.04618632,-0.059406828,0.042935416,0.0052849827,-0.031867046,0.07181694,-0.010257926,-0.04939172,0.037954435,-0.061523397,0.031451058,0.026463252,0.051569194,-0.11994378,0.081883535,0.024582665,-0.045688134,0.041326433,0.07581161,0.004062505,-0.034582257,0.025730938,-0.0018983192,0.08201697,-0.060035776,-0.024816763,0.029867018,0.0050657107,-0.05102907,-0.06238726,-0.0013048422,-0.058680248,-0.036369544,-0.0022592482,-0.012602037,0.027952043,-0.054426756,0.03061713,0.061156016,0.033659544,0.049625896,0.0077936426,-0.05459796,-0.052510973,-0.050590426,0.03270856,0.015957676,-0.048739616,-0.11551796,-0.0024802114,0.0009931156,0.01705769,0.087085694,0.22682059,-0.06007639 +3.1.3.2,Wide specificity. Also catalyses transphosphorylations.,384,1.0,0.038890466,-0.06836012,-0.04811701,0.035027813,0.042787444,0.03358035,0.010629572,0.070172034,0.040496398,0.00971745,-0.026747104,-0.0096187955,-0.094401255,0.06393767,-0.002645702,0.02633671,-0.082970925,0.044443995,-0.062637456,-0.059291814,0.07932971,-0.028740926,-0.0110483235,0.006028189,-0.023434374,0.0034577285,0.04811505,-0.059057273,-0.0081224805,-0.08655817,-0.036295388,0.018334389,-0.055210494,0.002896186,0.0069984263,0.12348267,-0.07158374,-0.0070652077,0.034864217,-0.04714625,0.06662309,-0.032538876,0.0037621954,0.014229279,0.007857418,0.0007125326,-0.023333533,-0.017888488,-0.03131755,-0.0070498195,-0.038166597,-0.008516073,-0.07845946,0.06759329,0.029728951,0.026204767,-0.07079555,0.0041982587,-0.0019686555,-0.000562866,-0.018179603,-0.03893284,-0.011883509,0.011805627,0.11739984,-0.05368874,-0.00318568,0.006688275,-0.0071769007,0.00509943,-0.016966423,-0.0038782973,-0.046092525,0.07034803,0.091559276,0.021213565,-0.020000186,-0.019011695,-0.013730704,-0.009636902,0.0053909537,0.03534549,0.10566843,0.03473171,0.061220136,0.059513718,-0.015984941,0.018158872,0.008315187,0.06591939,-0.022987293,-0.091419734,0.057550475,-0.06279118,-0.02409781,0.015161574,0.0427909,-0.010984309,0.057778522,-0.035346128,0.032739196,0.07593332,-0.0413612,-0.004312263,-0.022078495,0.018583225,0.0039137327,0.08041821,0.013085479,-0.035085153,0.0004990545,0.016161503,0.089852415,-0.012940469,-0.033539165,0.04216695,-0.024230618,-0.023444112,-0.015222472,0.0036582856,-0.014731058,-0.020110274,-0.05723556,0.06537082,-0.14425693,0.06943144,-0.096827455,8.090575e-34,0.047623623,0.018741978,0.047033835,0.092234164,0.02043,0.016364602,-0.068080656,-0.050438434,0.009443287,0.006867831,-0.043947548,0.012084437,0.05466244,0.044414204,0.043030597,-0.051478494,-0.07083192,0.09356636,0.080811515,-0.04971495,-0.009730566,0.054584995,-0.039291713,-0.06562393,-0.026679128,0.025955603,-0.021120554,0.025329623,0.0010348296,-0.006481322,-0.079190396,0.0022218756,-0.035241142,0.041334085,0.051661707,0.008937854,-0.09084868,-0.1044086,0.03545704,0.021423535,0.013150705,-0.03460034,-0.055098876,-0.030172223,0.045410447,0.0130210705,-0.034573503,0.026560314,-0.0666956,0.03859319,0.007453858,-0.0133677935,0.06433274,-0.053738683,0.033713523,0.008892643,-0.06837956,-0.08412935,0.018221976,0.055674773,-0.03375902,0.06362529,-0.00087395374,0.009665341,-0.0056028753,0.027698629,-0.10947714,-0.08062198,0.008428039,0.12910159,-0.06073312,0.029358355,0.1156429,-0.05586327,0.036168892,-0.0077859694,-0.015206119,-0.017748566,0.0050281016,0.07777088,-0.07586642,-0.015266499,-0.032590155,0.021917852,-0.056176163,-0.034013897,-0.00017281712,-0.11855948,-0.0680415,0.05444315,-0.033672456,-0.023852957,-0.032363962,0.017136984,-0.067561485,-2.668024e-33,0.046353396,-0.11589695,-0.040869802,-0.05389343,-0.026094751,0.011807826,-0.014679183,-0.108695015,0.03766928,-0.0004042712,0.03262944,0.020988394,-0.025881851,-0.09376899,-0.06357095,-0.054539382,0.07137459,0.11062458,0.044507436,-0.014674758,0.02187985,0.09192787,-0.10200335,0.11468845,0.12607878,0.011147564,-0.110299565,0.036995407,0.014546235,0.057015516,-0.033976644,-0.051880244,-0.051505215,-0.016332604,-0.021038271,0.04387888,0.023776015,-0.010167282,0.067771874,-0.005144203,0.010769993,-0.0013407572,0.02327318,0.052216366,0.03846439,0.045771968,-0.07925723,0.062115982,-0.009728018,-0.008086768,0.04601622,-0.051059917,-0.049363337,-0.030829467,0.014979897,0.056241985,-0.0013339069,-0.04172529,0.022405699,-0.044783305,-0.059942257,-0.058865327,0.047855347,0.019819422,-0.0057011144,0.06522861,-0.03698985,-0.05195341,-0.00054096576,-0.014532759,0.099917695,-0.012686328,-0.023765458,0.054529253,-0.013641867,-0.042183563,0.024083264,-0.10186555,0.021845182,-0.027626978,-0.008879851,0.020613825,0.027466703,-0.071405515,0.039338462,0.014335754,-0.0040469635,0.088816784,-0.0074318894,0.014701191,-0.03100149,-0.047288377,-0.039138537,0.00634823,0.032608446,-2.2547667e-08,0.03548768,-0.024123829,0.024528686,-0.064011164,-0.03181615,0.079370275,0.06329949,0.021709295,0.006945794,0.028776705,0.0007690754,0.057589084,0.07283048,0.0028837114,0.14203414,0.014065484,-0.04696165,-0.017315816,-0.08260849,-0.023596115,-0.049087934,-0.009014381,-0.09376681,0.023280649,0.028083557,-0.05333821,0.022997182,0.051898923,-0.019966193,-0.05508678,0.0674658,-0.051252954,0.024624307,-0.011833412,0.07367143,0.026822956,0.0058027855,-0.068270154,-0.0551164,0.05996632,-0.04857712,-0.019730395,-0.027337551,0.060243774,-0.045781255,-0.010263223,-0.021016201,0.022206007,-0.049087808,0.09813604,0.073820174,0.032086443,-0.0051582158,-0.06862231,-0.06124433,0.014285777,-0.016482666,-0.0487659,0.004657606,-0.04057495,0.11705172,0.09017989,0.19784857,-0.050817758 +3.1.3.4,"This enzyme catalyses the Mg2+-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol. In lipid signalling, the enzyme generates a pool of DAG to be used for protein kinase C activation. The mammalian enzymes are known as lipins.",384,1.0,-0.15097497,-0.045771703,-0.107767895,0.0256264,-0.033697475,-0.04644915,-0.01280592,0.0030194803,-0.018655093,-0.039292153,-0.0611805,-0.0072252555,-0.069789164,-0.0493357,0.033340782,-0.025318583,-0.014328202,0.08405218,-0.01618705,-0.042445876,0.08044143,0.00024383937,-0.009310389,0.017997805,0.024714833,0.003064077,0.08941465,-0.009765059,-0.03084919,-0.031905916,0.028497493,-0.074889734,0.045064893,-0.052429274,0.00962742,0.06782245,-0.031590957,0.04295965,0.008819026,-0.049400013,0.06485979,-0.039927114,0.06197301,0.014660753,0.033734493,-0.06882758,-0.090143345,0.04346209,0.055155974,0.064226404,-0.017702874,-0.028040323,-0.047805496,-0.050564144,0.036684155,0.022516182,-0.10332111,0.044117104,-0.022704864,-0.012961966,0.018195692,-0.051831514,0.027101064,0.043147184,-0.02447359,-0.07004371,0.047228776,-0.068714544,0.049528193,-0.023317017,-0.059019826,-0.058659587,-0.040290926,0.043017324,-0.07710596,0.044258207,-0.01121109,0.031074086,0.07817612,-0.054310385,0.13792405,-0.025036985,0.081355676,0.14164506,-0.030773193,-0.019748757,-0.013745463,-0.02010703,0.0006345785,0.089127794,0.05160776,-0.020641364,0.01582219,0.01854247,-0.11050173,-0.01575863,0.0049606203,0.012907069,0.0016077394,0.012343404,-0.0029535259,0.07467028,0.037602067,-0.0069338055,0.014730978,0.014870872,-0.061047815,-0.03508953,0.016480966,-0.005790998,0.038289633,0.033029716,0.06584779,0.008970932,0.012561603,0.044110406,-0.039971534,-0.04551699,0.0213475,-0.04118108,-0.021959553,-0.03461435,0.011283749,0.041772127,-0.027115889,0.024212327,-0.028456628,3.0552976e-34,0.033843864,0.020910166,0.035666607,0.0021779821,-0.04543932,-0.08392584,-0.018647322,0.009431116,-0.071132466,0.0039239,-0.016312191,-0.07582944,-0.006498228,0.10089481,-0.022136545,-0.02315227,0.03369484,0.031245993,0.10082594,-0.010933353,0.0040450646,0.03651842,0.020894289,-0.05530902,0.084627,0.11214257,-0.003951049,0.0049742493,0.03559183,0.017111076,-0.011253117,-0.11702352,0.01665573,0.08118368,0.04808515,-0.032061186,-0.080583796,-0.044012893,0.0630543,0.079441406,0.0043182615,-0.093179934,-0.03825828,-0.006903336,-0.026751984,0.05579876,-0.081267305,0.057592392,0.018478854,-0.00040541586,0.06398187,-0.029127173,0.06714641,0.127407,-0.0535304,-0.0013891488,-0.05290693,0.01031186,0.049709417,-0.0015528523,0.035882533,0.038206518,-0.07244899,0.04437824,0.06643417,-0.0058994684,-0.14178666,-0.07081967,-0.0026630978,0.051389903,0.08131162,0.0015271241,0.0673462,-0.0008240668,-0.013417522,0.024653312,0.035687458,0.12407124,-0.020884277,0.068268165,-0.0037812258,0.040746376,-0.010971579,-0.034278832,-0.05033206,0.03364449,-0.037836034,-0.09859721,-0.058348022,0.026492234,-0.09140587,0.0139464,-0.022098005,0.04797964,0.026953347,-2.5346329e-33,0.028462164,-0.012366325,0.06213112,-0.010055792,-0.044631124,0.057483993,0.043107674,-0.059878837,0.09231859,0.03324428,0.0028813137,-0.022264475,0.034535203,-0.07952375,0.03567999,-0.030779267,-0.04907376,0.010165721,-0.07113472,-0.057494294,0.055042494,0.04925921,-0.052446693,0.11473532,0.01542331,-0.060525883,-0.03246782,0.026229871,-0.025122596,0.14284731,0.036409877,0.055646174,-0.033475284,-0.047377802,-0.065537706,0.030565439,-0.009250585,0.031211521,-0.08224681,-0.010121249,-0.07059789,0.028852815,0.059110325,0.027127776,0.0855761,0.029523639,0.028216017,0.052770186,0.011856393,-0.04151286,0.010273215,0.007786487,-0.004622257,0.053001072,0.029582215,0.09323788,0.0509942,-0.018391738,0.0637965,-0.06459682,-0.05662171,-0.08945996,0.038090434,0.0064577945,0.034326088,0.12506324,0.016211616,-0.014372638,0.025373029,0.037275467,0.044881187,0.040476166,-0.008345084,0.054714583,-0.005044686,0.06001158,-0.06380624,-0.021426594,-0.005238536,-0.04697169,-0.026426544,0.006579265,0.016287114,-0.04162123,-0.04277769,-0.036319464,0.00088364707,0.074694075,-0.031377375,0.03322905,-0.069666035,-0.05906346,-0.13121624,0.0019810996,-0.04127584,-3.6328366e-08,0.04100839,-0.07733653,-0.0041152355,-0.06794881,-0.019847207,0.052991062,0.05533389,0.007580754,0.01832421,-0.10311447,-0.019452484,0.06584798,0.0016686376,-0.038809236,0.004293798,0.02950998,-0.016492058,0.04909236,-0.014566863,-0.060244277,0.0674645,-0.044156052,-0.07818127,0.080629684,0.042886134,-0.07383814,-0.042748734,0.08837793,0.0148243075,0.0011518431,0.024104916,-0.001383016,-0.020548152,0.012393094,0.05839776,-0.041763842,-0.052588828,-0.07223417,-0.009956071,0.015804885,-0.0482846,0.009835353,0.03899257,0.015261652,-0.10923582,-0.015822055,0.01084508,0.033990823,-0.045610353,0.013959584,-0.05517501,0.030143179,-0.059732378,-0.0797993,-0.037895266,-0.033130538,-0.018954359,-0.028660076,-0.070687816,-0.011060133,-0.007552611,0.021622127,0.10467961,-0.041571036 +3.1.3.5,Wide specificity for 5'-nucleotides.,384,0.99999994,-0.03633752,-0.09080099,0.008084837,-0.09104613,-0.037017606,-0.036873084,-0.06580483,0.07748201,-0.04351097,0.06505532,0.019667879,-0.009532701,-0.16420524,0.06922328,-0.08539809,0.032714624,-0.09729338,0.0667096,-0.018565271,-0.027918331,0.04227282,0.03855292,0.014678714,0.0374824,-0.086588405,0.015567254,0.0140403025,0.05064389,-0.010558843,-0.076487236,-0.017895985,0.001704774,0.04261504,-0.05198275,0.039067928,-0.0060259067,-0.037214406,0.028295519,0.072506264,0.058166284,0.10636587,0.01811336,0.049596723,0.1289858,-0.016383866,-0.0081396,-0.075372785,0.053805098,-0.025475604,0.041521627,0.019498175,-0.029657666,-0.061563563,-0.024948772,-0.01333352,-0.016385067,-0.08774862,-0.073431626,0.013810082,0.022517968,0.023102704,-0.025932278,-0.014743527,-0.032231554,0.073696814,0.030877665,0.08557341,-0.10344351,-0.028438307,0.087131165,0.013752443,-0.024832295,-0.037451297,0.09893725,-0.01711155,0.0130095575,-0.0098764,-0.030413847,0.011159194,0.02147881,-0.06071208,0.033888076,0.020929145,-0.01921018,0.019351438,0.016041607,-0.011367426,0.08707553,-0.041321397,0.0007277692,0.031690262,-0.03990867,-0.02976235,-0.10289421,-0.0829214,0.0015016589,0.003331317,-0.015079541,0.02643756,-0.038160622,0.10809091,0.0023729294,-0.052647557,-0.029938893,0.003020997,0.019898947,0.055191193,0.0010688757,0.0037794712,-0.013320235,-0.030257678,0.020385757,0.01295142,-0.012200994,-0.00398246,-0.05772618,-0.069415934,-0.005588732,0.057774346,0.009070982,-0.022549143,-0.03832416,-0.017232457,0.02818449,-0.050864372,0.02808371,-0.057900887,-2.1436253e-33,0.008235533,0.018321019,0.040491663,0.09035794,-0.020760553,0.04454662,-0.031791057,0.0038687144,-0.09704982,0.08498815,-0.017070213,0.0011120511,0.11521764,-0.025047565,0.021083342,0.07000826,-0.02745817,0.061432958,-0.05184081,-0.033740733,-0.027523253,0.06708786,-0.0032759856,-0.010726516,0.08389169,0.017011207,-0.087584384,-0.0013866512,0.077465914,-0.020920483,-0.064054534,-0.03359176,-0.020808754,-0.0042393235,0.13079555,0.0007916217,-0.00033786517,-0.016056977,0.06318789,0.062684715,0.06355592,0.028807305,0.016274683,0.031083934,0.06874361,0.0552612,-0.0048688403,-0.0076699313,-0.10298157,-0.03643673,0.0065888176,0.019886555,0.05317991,-0.03293233,0.07869952,-0.0052917697,-0.021332394,-0.0029669737,-0.024836602,0.07871141,-0.0053672767,0.04629058,0.010481682,-0.021306224,-0.0051224087,0.023486717,-0.08361344,-0.043112967,0.037965592,0.105438314,0.033827707,-0.05586557,0.06514221,0.005095594,-0.04274337,0.01919109,0.029195242,0.0155518195,-0.032429937,0.10015733,-0.04152797,-0.004219525,-0.034550097,-0.06150947,-0.061584625,-0.012965125,0.072924934,-0.06613279,-0.044040572,0.0380969,0.12356412,-0.09774343,-0.02348753,-0.090875834,-0.04284884,-8.0181085e-34,-0.0013005155,-0.06386264,-0.0056136977,0.011679061,-0.08941196,0.023851413,0.018919613,-0.008045227,-0.01819489,-0.0055440404,0.09000304,0.089631476,0.025135357,-0.047638115,0.011944982,0.059199676,-0.03552442,0.09778512,0.063608214,0.009715682,0.08772137,0.012657102,-0.00684548,0.066834055,0.09137367,0.038515262,-0.04562161,-0.035163138,0.012402522,-0.024460703,-0.13208301,-0.037718054,-0.0012998626,-0.0019194554,0.009074922,-0.029071817,-0.0068229944,0.052881766,-0.008973614,0.01942733,-0.051656257,0.10047787,0.01862442,0.04580998,-0.021095,0.015796106,-0.003031067,0.022339955,-0.0004491901,0.009581893,-0.021362511,-0.023308178,-0.031224899,-0.020392962,-0.017140884,-0.043397572,-0.068015106,0.022365691,0.04521959,0.02427363,-0.05184592,-0.1078394,0.024297426,-0.038119234,0.0050435234,0.04804314,-0.0075065736,0.012695154,-0.03220817,-0.080812454,-0.052976582,-0.057928253,0.06968805,0.0026618966,-0.07171626,-0.025587143,0.023230396,-0.059314728,0.00919995,0.04662018,-0.074609354,0.012080056,-0.0047028405,0.027400278,0.05488836,-0.030272659,0.118278645,0.07701731,0.014325652,0.020714879,0.04415985,0.0157983,0.0019520667,-0.03347489,0.010725998,-1.8456362e-08,0.11543348,-0.011804644,0.011884868,-0.099304795,0.03198095,0.08736566,-0.090039425,0.01699235,0.07724989,0.112714164,0.04387818,0.025240555,-0.0044069216,0.08913639,0.088707276,-0.00030118617,-0.1144804,-0.07185142,-0.02618957,0.024241626,-0.11538559,0.067893505,-0.046416778,-0.021602789,-0.03932558,0.023026185,0.008866738,0.009054113,-0.051120646,-0.052068878,0.05279406,-0.0060156663,0.0023677659,-0.042584207,0.005055504,0.046530776,-0.013128188,0.027651059,-0.041562613,0.04828306,-0.09355395,-0.09726118,-0.057392128,0.037905768,-0.030399501,-0.04973722,-0.009520284,0.036016755,-0.06507793,-0.014387575,-0.050704733,-0.001434477,-0.010374211,-0.058630094,-0.0046606786,-0.0299345,-0.0382501,-0.035733934,-0.06918117,-0.0044425274,-0.0038027281,-0.026177274,0.10311549,-0.033007856 +3.1.3.6,Wide specificity for 3'-nucleotides.,384,1.0,-0.027707653,-0.12234723,-0.072030105,-0.12290162,-0.044101465,-0.039225347,-0.05673578,0.038139682,-0.022952847,0.034618903,0.02208363,-0.058626585,-0.14251742,0.07506383,-0.014450245,0.022626754,-0.11970186,0.097011276,0.041369,0.0043682046,0.05928417,0.052435726,0.0581431,0.036677238,-0.06967531,0.027595688,0.03170167,0.053047575,0.019176008,-0.03937818,-0.011794959,-0.021589367,0.08165679,-0.03592141,0.09235573,-0.04314814,-0.06871193,0.020390602,0.031208012,0.07980935,0.1059814,0.04753926,0.07286736,0.10414781,-0.0016002345,0.008021071,-0.08891337,0.041563652,-0.028733913,0.028356751,0.045500968,-0.020731607,-0.063387476,0.013024255,-0.025732106,0.004595755,-0.077453755,-0.028066903,-0.004406505,0.056153145,0.021917518,-0.026971914,0.008962342,-0.056191906,0.16554315,0.023435107,0.07006341,-0.11655781,-0.029516125,0.08598514,0.0029118396,-0.015146912,-0.06814855,0.053449355,0.01438196,0.01854678,0.03798939,-0.00021586538,-0.04051182,-0.025041683,-0.03642498,0.014536695,0.032740656,0.042018346,0.011385062,-0.009241356,-0.04941263,0.061622318,-0.07501878,0.06681441,0.013185479,-0.037402455,-0.0019194066,-0.07697133,-0.03590405,0.0324153,0.03825547,-0.0032339303,0.052022167,-0.030466944,0.10367284,0.050544605,-0.036734823,-0.022780294,0.023953646,0.046552587,0.0010005992,0.0044629,-0.020373534,0.034532145,-0.009832027,0.0074303695,0.019331608,-0.030432079,-0.06516338,-0.033175208,-0.028859867,-0.032225277,0.093350254,0.01747356,-0.0018772237,-0.0493302,-0.011699053,0.006536677,-0.0098866215,0.035287406,-0.03777894,-2.2701771e-33,-0.01023171,0.0250263,0.0037250565,0.060351785,-0.03416925,0.05495032,-0.04706493,-0.02924882,-0.11266041,0.07472919,-0.03036386,-0.0053091384,0.14488739,-0.0028662728,0.0052072937,0.04159205,-0.041013006,0.046917006,-0.04276471,-0.035831135,0.013359761,0.04497204,-0.00067145674,-0.029610079,0.05957238,-0.021820186,-0.0726559,0.011576278,0.08401032,-0.028353743,0.025280248,-0.04145519,-0.05711179,-0.0056073596,0.10446278,-0.016445465,-0.043652765,-0.08275726,0.03958397,0.11324305,0.0020950444,0.031980872,0.053717267,-0.018654974,0.057988502,0.04963177,0.04175719,-0.02142812,-0.08506181,-0.042816877,0.030156173,0.019232836,0.048245244,-0.031532727,0.092081934,-0.03308458,-0.027929943,-8.741146e-05,0.001672055,0.03145088,-0.035725724,0.033396397,0.012750075,0.007903142,-0.008976333,0.010865882,-0.11960654,-0.012785926,0.04974122,0.087242946,0.01300626,-0.098502204,0.03302619,-0.032472376,-0.042857908,0.015572528,-0.0027729159,0.028273644,-0.02392166,0.0497127,-0.03731979,0.023450036,-0.013871476,-0.023881106,-0.07942705,-0.052909914,0.053454753,-0.0766752,-0.052405793,0.029078066,0.09227254,-0.03466804,-0.044763003,-0.06327605,-0.0302187,-8.7383835e-34,-0.017178217,-0.027738875,-0.008953776,-0.030703392,-0.07793453,0.016320182,-0.010418239,0.019582344,0.0068447795,-0.0351337,0.092080586,0.051872008,0.005025191,-0.119433925,0.025674673,0.03498602,-0.039865892,0.073755614,0.023563443,0.013019989,0.09735689,0.012031277,-0.032413498,0.077848084,0.0028917722,-0.005008003,-0.060378455,-0.030104114,-0.00053372,0.02487433,-0.13961504,-0.02317653,0.0010903506,0.025144031,0.00593836,-0.020178553,0.020800108,0.03427599,0.010966342,0.024210177,-0.020684298,0.098237135,0.013161074,0.050781183,0.011526778,0.0687296,0.022645846,0.029511718,0.0031048183,0.023750205,-0.05017013,-0.03123617,0.02140621,-0.007523051,0.0474143,-0.021160236,-0.0866765,-0.043053184,0.057292383,0.011625013,-0.038900718,-0.092236206,0.027281163,-0.02631393,0.008556077,0.031126335,-0.057943396,0.004423516,0.01732322,-0.052684553,-0.04248136,-0.03979703,0.041915763,-0.016869582,-0.06988832,-0.054732274,-0.027548663,-0.047860753,-0.005947863,0.0063135163,-0.024456592,0.023657436,0.034015168,0.043765917,0.06582268,-0.040481552,0.10441914,0.08261948,-0.031087296,-0.05367517,0.04643611,0.022321839,-0.009060475,-0.0025797451,0.028472587,-1.8887242e-08,0.11709207,-0.0075457753,0.010474971,-0.09148737,0.009277782,0.080066964,-0.06806191,0.056890074,0.024485292,0.10676457,0.031164704,0.025933394,-0.015547553,0.03132813,0.13722159,0.0031375557,-0.08569631,-0.06539307,-0.054520022,0.013991444,-0.11300362,0.08573427,-0.040436003,-0.02490144,-0.047619708,0.07711453,-0.0070112823,-0.0016608755,-0.04060367,-0.023982123,0.07588561,-0.021349344,0.036429968,-0.042510897,-0.031260032,-0.0054182396,-0.032194197,0.0018109893,-0.0028889547,0.014579108,-0.05629744,-0.035883613,-0.07640546,0.04285481,-0.023313224,-0.047787413,-0.036239028,0.05366452,-0.10844768,-0.03168139,-0.042163596,-0.028184889,-0.016409727,-0.021936204,0.008953815,-0.054529373,-0.0698521,-0.025847333,-0.069317006,-0.0015274023,0.017541159,-0.03336962,0.10449611,-0.028754026 +3.1.3.7,"Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates.",384,1.0,-0.0659353,-0.1157219,-0.038276613,-0.058268994,0.02743261,-0.029274369,-0.001235901,-0.0057801926,0.09183882,0.031115297,0.081218846,0.02813513,-0.05999198,0.0973657,-0.001098658,0.036415946,-0.084086984,0.08097602,0.019675713,-0.011932566,0.13185178,0.020391507,-0.016669028,0.007025981,0.009077773,0.052464094,0.04313005,0.0538427,-0.006820321,-0.051363025,-0.048148233,-0.033565823,-0.01482036,-0.077394485,0.058073364,0.047594387,-0.060927138,-0.030894324,0.024802806,-0.011468915,0.08290217,-0.05668937,0.040514104,-0.012611743,-0.018871281,-0.017978145,-0.036043458,0.021721598,0.057821978,-0.032106955,-0.044037506,-0.051580098,-0.079868905,0.048056595,-0.0511558,0.05559168,-0.123515256,0.08629939,0.020063894,-0.0074827815,-0.035260044,0.014896089,0.00069743866,0.07877244,0.05451885,0.0076794713,0.043679506,-0.100641824,-0.07074369,0.0084736915,-0.061166685,-0.0022852789,0.05345356,-0.038677964,0.057038847,0.024463076,-0.023824384,-0.0117962435,0.013679649,-0.049698994,-0.005728827,0.007820831,0.02870941,0.078292936,0.0071853087,-0.021268265,-0.040120095,-0.061715733,-0.015191173,0.0002471179,0.036780536,-0.049699113,0.00826405,0.022734853,-0.01758428,0.027087437,-0.02217778,0.052320186,-0.008819689,0.018321909,-0.034821637,0.033134274,-0.030696271,-0.05020987,-0.017864592,0.041001745,-0.05998191,0.008254279,-0.02693069,0.03969172,-0.038933598,-0.015405076,0.04373957,-0.010349736,-0.073287524,0.07708566,0.032671794,-0.034267493,-0.05723836,-0.035100367,0.0063479687,-0.08429827,-0.028703341,0.016128823,-0.09660945,0.054680277,-0.061403137,-1.1405795e-33,0.09699279,0.066789486,0.11311993,-0.029596252,-0.02222254,-0.00452301,-0.09781165,-0.029802682,-0.067825876,-0.0051357304,-0.026603805,-0.017973622,0.0888611,0.009758491,-0.030854769,0.01551467,-0.019543977,0.039494444,0.055260196,-0.029846366,0.044812296,0.08686801,-0.07795418,0.003991505,-0.010433575,-0.0125279,-0.061172046,-0.013743456,0.0067980615,-0.0024375436,0.100323744,-0.046807162,-0.05319558,-4.1090403e-05,0.0025242234,0.0018020908,-0.10498742,-0.07833262,0.030801283,0.0058235163,0.024884224,-0.03633798,0.012681957,0.0062969737,0.035797212,-0.0895284,-0.04947765,0.06344498,0.06922143,0.07541011,0.029231444,-0.032416828,0.06561822,0.013720054,-0.013412684,-0.028143795,0.018875813,-0.072457105,0.009125078,0.0148695465,-0.026580226,-0.016020449,0.011494955,-0.04258309,0.0047061937,0.00018698709,-0.07637413,0.0006082681,-0.018633362,0.059318323,-0.056396145,0.0095966095,0.06933719,0.05620744,-0.03770765,-0.01440531,-0.0022293623,-0.006668024,0.025436742,0.062100977,-0.022181684,-0.07215096,0.055473972,-0.015435068,-0.09940139,0.0005498048,-0.01102149,-0.12791044,-0.013627077,0.016814036,0.04316878,-0.062148478,-0.10878246,0.0028160699,-0.0037121903,-1.9016692e-33,0.051150672,-0.028050035,0.002718228,-0.047193184,-0.036056392,-0.023332722,0.068232104,0.031728864,0.04089001,-0.0016828995,0.07667686,0.0248972,-0.015626196,-0.0548578,0.0322333,0.07373173,0.044004284,0.024294188,0.009542824,-0.00031287104,0.042205483,0.120737866,0.06320469,0.13273004,0.050894953,0.015169127,0.031040385,-0.028567525,-0.030973777,0.15477258,-0.03484011,-0.027930431,-0.058864325,-0.02888281,-0.03620078,0.00857031,-0.058114707,-0.045938488,-0.014074595,0.030572064,0.040789846,-0.023865545,0.10359925,0.050038382,0.036426507,0.08886156,0.05559191,0.057549704,-0.056852568,-0.0745215,-0.0331045,0.0503003,-0.02392465,0.08679263,0.08699713,0.08263731,-0.026971728,-0.031540662,-0.045411844,-0.041932955,-0.023679083,-0.04427592,-0.02216427,-0.11456137,0.012062549,0.030266192,-0.022798965,-0.030582596,0.07262023,-0.023983894,0.016414901,0.0006632949,0.043442402,-0.016203076,-0.061629824,-0.10891417,-0.044907518,-0.014909533,-0.026274906,0.0011634133,-0.031040916,0.029441535,0.044140995,-0.08304794,0.037074503,-0.060912583,-0.030875713,0.08981924,-0.016965965,0.0135274995,-0.031616032,0.076500624,-0.00842121,0.024137901,0.04573664,-2.647102e-08,0.061272055,0.0007514797,0.08256969,-0.045784038,-0.05297306,0.030128088,0.0806377,0.08604528,-0.008388897,0.017008496,-0.016733397,0.069289185,0.058975518,-0.03530149,0.113025896,0.033482548,-0.06356035,0.02438721,-0.087043986,-0.09730814,-0.09090682,-0.042253524,-0.034050744,0.04779674,-0.01515995,-0.004001813,0.027887316,-0.021359097,-0.07483262,0.005199044,0.07873235,-0.0340479,-0.026487246,-0.0848359,-0.02036211,0.07993452,-0.038778193,-0.033378094,-0.024616644,0.037159633,-0.045959435,-0.01751225,-0.044256993,0.09001256,0.016781911,0.071988545,-0.013916911,0.062497776,-0.059729554,-0.020882383,0.036406927,-0.04640202,-0.046107855,-0.035298754,-0.08533615,-0.040611163,0.04218766,-0.0075729336,0.056457363,-0.014231304,0.027042009,-0.003913535,0.1362218,-0.023568776 +3.1.3.9,"Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].",384,1.0,0.009979269,-0.015840324,-0.048705783,-0.010175076,-0.020574264,0.05603719,0.043062434,0.036873303,0.051126957,0.13018079,-0.00683378,0.038850017,-0.035476457,0.003598206,-0.013277658,-0.044568256,-0.05574552,0.014999887,0.015619634,-0.027206808,0.15086344,0.044820495,-0.04038075,-0.0053682798,0.050663467,-0.043173645,0.054764815,-0.08221776,-0.046668883,-0.04168332,-0.086111605,-0.112592444,-0.026124092,-0.049144253,0.040263128,0.1171721,-0.013277803,-0.048207864,0.010927872,-0.004973888,0.056807004,-0.024050936,-0.000913101,-0.021599846,-0.053125426,-0.007068091,-0.06392966,0.018450668,0.025386382,-0.039470363,-0.041039906,0.012786417,-0.022993777,0.0500877,0.0016251366,-0.03114453,-0.04168612,0.06772805,0.0063566808,-0.0026286351,-0.08134235,0.001982735,0.087191544,0.035137966,0.029509896,-0.041703008,0.058514666,-0.034600336,-0.051206872,-0.043987673,-0.07412677,-0.023084644,0.05612606,-0.031090112,0.014910535,0.024971414,-0.024465838,0.04377728,-0.015382031,-0.07843054,0.08041999,-0.051553536,0.01584852,0.004614726,-0.031149482,-0.016205046,-0.051233914,0.041752264,0.013315851,0.029794313,-0.031077214,-0.04314944,0.051538106,-0.042328984,-0.01674527,-0.020596651,0.033509918,0.029275957,0.07036849,-0.059938345,0.024693234,0.11897744,-0.015076748,-0.05737961,0.0055905217,0.122238964,-0.032331694,0.0780987,0.015376804,0.018759316,0.013724206,0.061279193,0.033471223,0.015715694,-0.07188944,0.044316385,-0.048026815,-0.07096067,-0.04577025,0.0015905631,0.014687331,-0.06987755,0.055847242,0.024488961,-0.083626114,0.0980265,-0.0086975,3.5560974e-33,0.028249174,0.04774877,0.018973941,0.0037168402,0.017544618,0.022542665,-0.07048369,0.022283213,-0.018586326,-0.029540315,-0.10709824,-0.016164625,0.03608359,0.03949714,0.016305694,0.014875661,-0.016575502,0.04062554,0.10809487,-0.059370063,0.033645738,-0.015053654,-0.014263476,0.026409756,0.027170882,0.063175455,-0.12640691,0.056863513,0.00043737175,-0.012435764,-0.0070034345,-0.07056677,0.008959251,-0.03488423,0.0008149852,-0.07706303,-0.04239014,-0.06803626,0.05052403,-0.019795746,0.04702886,-0.09082116,0.002912509,-0.024574628,0.017507518,0.0048350473,-0.028446794,0.00028602954,0.047912326,0.067524105,-0.038406227,-0.056090765,0.09509907,-0.04607338,-0.052326903,-0.028745275,-0.02191754,-0.09873321,0.071383364,0.11480443,0.006655172,0.07394348,0.004706662,-0.04387997,0.032639492,-0.024732117,-0.1065438,-0.061158754,-0.08441476,0.088992104,-0.041951418,-0.03472484,0.041957423,-0.0443199,0.032535203,-0.026225435,0.009479947,0.03184726,-0.046747025,0.05221851,0.05658457,0.026675627,-0.03488999,0.00400754,0.050048254,0.013469718,-0.0027197693,-0.088254765,-0.050010376,0.058660544,-0.028766325,-0.039002284,-0.053373214,-0.024075953,-0.009221652,-5.2110734e-33,0.08219881,0.021540085,0.029174048,-0.046168193,0.002439589,0.04588141,0.051908523,1.320444e-05,0.100083426,-0.04750821,-0.027699158,0.030840281,0.037030905,-0.0877603,-0.02548162,0.01609617,0.051819485,0.053985693,-0.021433242,-0.07160252,0.007175676,0.061253507,-0.040055048,0.083161294,0.10459554,-0.061289676,-0.060730476,0.0492188,-0.021021588,0.078615926,0.03771803,0.004151362,-0.06161427,-0.0041763657,-0.051774703,-0.020261647,-0.07845568,-0.018432586,0.03252691,0.074943796,0.005299888,0.057631973,0.06402536,-0.044569787,0.035809945,0.07597212,-0.0843908,0.009268239,-0.038300756,0.007285085,0.0014469204,0.05506575,-0.07247973,0.042863276,0.06718412,0.055625774,-0.007283319,0.074692905,-0.0073425868,-0.053008743,-0.052063007,-0.06597796,0.04420008,-0.042595856,0.026255615,0.04869615,-0.011776336,-0.037632674,0.020733848,0.06988161,0.039928064,0.019521786,-0.025831837,0.0122114485,-0.03886713,0.007752371,-0.063851744,-0.05520504,0.019763693,-0.09736164,0.06875989,-0.016679263,0.0456463,-0.07863224,-0.01037301,-0.02149723,-0.02604232,0.06625563,0.026291892,0.04926845,-0.055801474,-0.048695527,-0.01693365,-0.01360046,0.057531506,-5.1787218e-08,0.039188214,-0.0073185405,0.031064473,-0.032054454,-0.016086845,0.04834289,0.047843114,0.040447515,0.033062175,-0.057235282,-0.0080004865,0.00559839,0.026823133,-0.045630954,0.058920596,0.034698818,-0.067102246,0.07583378,-0.01924479,0.019359061,-0.024647392,-0.012393671,-0.11962632,0.07870093,0.06881894,-0.05601406,0.10900556,-0.009982762,-0.025007296,-0.015937395,0.007168771,-0.041665044,0.011039913,-0.06249139,0.024316216,-0.04283505,-0.05503817,0.030230707,-0.041144475,0.009948862,-0.022210421,-0.029043974,-0.030220322,0.05992161,-0.0568962,0.09348823,-0.012061304,0.09440728,-0.010144884,-0.018788842,0.038268093,-0.020681739,-0.080608904,-0.13478282,-0.065489285,-0.05140744,-0.036857963,-0.019854695,0.0105961785,-0.07211762,0.06826999,0.11615433,0.16241738,-0.05249519 +3.1.3.10,"Also acts, more slowly, on D-galactose 1-phosphate.",384,1.0,-0.02207273,-0.16883932,0.026326803,0.022182498,0.031155076,-0.07341033,0.021137878,0.02386222,0.067958206,0.06210119,0.028290924,0.065475926,-0.05659627,0.098811306,-0.009212775,-0.012845457,0.030959982,0.03045809,-0.004862345,0.059331138,0.1541486,-0.022226378,0.013782074,-0.009036269,0.07913911,-0.033142332,0.014353764,-0.029976856,-0.014304093,-0.12805207,-0.008446381,-0.008354837,0.040441647,-0.016231045,-0.015231148,0.10442943,0.02089421,0.012078037,-0.008467365,-0.053249806,0.035660338,-0.041169852,0.040960975,-0.0023862517,-0.015287857,-0.019374358,-0.067402974,0.021029798,0.025230337,-0.017231602,-0.06559849,-0.08928577,-0.06654144,-0.054843456,0.044913914,0.058527175,-0.067317344,0.040178068,0.017097248,-0.058499403,0.002366632,0.032817118,0.031050675,0.05055856,0.06287212,-0.058973227,0.07564739,-0.051283196,-0.009657371,0.0029410806,-0.0036750536,0.00987885,-0.035700712,-0.055037927,0.030844707,-0.026339877,-0.033675842,-0.071439,0.035731416,-0.012364081,0.026041035,0.023172297,-0.002641197,0.015402364,-0.021924121,0.004830966,0.06486696,-0.0429448,-0.08074351,-0.04586462,0.030870004,0.0011443006,-0.01407577,0.012279046,-0.02171898,-0.006624388,0.029427128,-0.014909123,-0.008899114,-0.048557475,-0.047343124,0.05066589,-0.0072245062,-0.02049932,-0.022683619,0.04574599,-0.013143947,0.05599018,-0.00984664,0.07332848,0.024541775,0.0069423,0.028769849,0.076605864,-0.10876818,0.07708403,-0.020947196,-0.011252592,-0.070415124,-0.015382154,0.021236889,-0.06307246,-0.014927848,0.02456889,-0.026943428,0.07457638,0.0029028845,-2.8191953e-33,0.09492865,-0.011063869,0.0143425865,-0.045748964,-0.0120654,-0.013356622,-0.08928874,-0.035555027,-0.025675658,-0.003211721,-0.061766542,-0.064651035,0.047889255,0.030879714,-0.0775762,-0.01790047,-0.0045484635,0.02035203,0.029392956,-0.038259055,0.008154307,0.06447599,-0.09004127,-0.024705978,0.037620973,-0.03585919,-0.03059864,0.049557343,0.040761877,-0.0050143884,0.05591625,-0.06448533,-0.06502867,0.049784776,0.066356935,0.039702546,-0.042334702,-0.043680485,0.04829319,-0.080659516,-0.02548532,0.0056377933,-0.043898903,-0.026108762,0.009074314,-0.05703004,-0.05122466,0.058918428,-0.0030985586,0.09776517,0.072623804,-0.043543264,0.024433644,0.017687282,-0.019905346,0.03209379,0.015973952,-0.043190263,-0.014219602,0.069505,-0.010178066,0.01187217,-0.027270833,0.04212157,0.046164986,0.025019592,-0.07868047,-0.004761067,-0.008778278,0.036386266,-0.07175807,-0.064698264,0.09698954,-0.04272217,-0.030037526,-0.019568164,0.029832672,-0.0072042276,-0.0047756503,0.0048129484,0.032306354,-0.04878578,-0.017960384,-0.034389418,-0.042973895,0.039209243,-0.030395923,-0.11978485,0.007047608,0.05930998,0.054489437,-0.067564785,-0.067085244,0.0032295876,-0.018171638,2.6393154e-34,0.065818764,-0.08859202,0.07595552,0.056236528,-0.02450192,0.070598915,0.027996115,0.0066897105,0.06454472,-0.07049056,0.05268919,0.0132591,-0.09848324,-0.045062955,-0.010628573,0.084920004,0.06991013,0.06818927,-0.01397027,0.029148938,-0.0062382454,0.13803107,0.012502902,0.1006274,0.031337842,-0.018185554,0.00030041524,0.0041098013,-0.027109459,0.037455823,0.048233535,-0.005146429,-0.094470695,-0.09998487,-0.07495646,0.013603709,-0.058485627,-0.018514445,-0.035794724,-0.0012081675,-0.012756437,0.0035459283,0.105332695,0.033837434,0.070194714,0.056913916,0.006236531,-0.0069964067,-0.0038045854,0.02479004,-0.01478608,-0.0007175348,-0.019607095,0.08517692,0.08293271,0.05977944,0.06943363,0.0062227803,-0.04430607,-0.0011017092,0.0014959087,-0.021653598,0.033229932,-0.10127142,0.06189547,-0.0041593583,-0.04436183,0.051506363,0.09892122,-0.02219602,0.07834933,0.0058312947,-0.0144531485,0.027967982,-0.060115032,-0.039624956,-0.10175992,-0.078902446,-0.026177846,-0.021023458,0.0063384073,0.121233895,-0.031413354,-0.08445082,-0.058472265,-0.03462441,-0.011766635,0.062091403,-0.024711363,0.059641533,-0.09269164,-0.005247773,0.038656894,0.011369542,0.06356067,-1.9920318e-08,0.07671257,0.019757962,0.07346208,-0.0638642,-0.021975176,-0.0043259677,0.060765393,0.08842145,0.011590551,-0.061796937,-0.04497843,0.16531296,0.054633617,-0.025855351,0.07014607,0.007946824,-0.01893723,-0.036822055,-0.072978795,-0.031576067,-0.07016784,-0.021365011,-0.10304204,0.0077982764,-0.048925035,-0.023368396,0.06342347,0.07834034,0.0049287337,-0.04963012,0.05935498,0.013155629,0.0067976313,-0.041857924,-0.08599567,0.047628097,0.006333332,0.019801872,0.024820045,0.039094698,-0.019395517,-0.037694212,0.015494622,0.03630693,-0.10883124,0.027702302,-0.021617126,0.009521106,-0.020801622,0.051177196,0.030579068,-0.0069770995,-0.14078753,-0.06166037,-0.067188,0.02543587,0.0076384926,-0.016591134,0.07501239,-0.032159988,0.05021127,-0.059676606,0.10969943,-0.0042218724 +3.1.3.11,"The animal enzyme also acts on sedoheptulose 1,7-bisphosphate.",384,0.99999994,-0.029118259,-0.09447671,-0.004148698,0.044852782,0.012137118,0.009788527,0.04510753,0.0676856,0.058360722,0.044266768,-0.01858836,-0.042328645,-0.046780184,0.068159275,-0.013436326,-0.0009448996,0.008665573,-0.02392822,0.060420904,-0.04409668,0.13653767,0.00017718555,-0.0095576225,-0.005963133,0.059490036,-0.053059027,0.013590453,-0.042964958,-0.047069233,-0.045926724,-0.047801763,-0.06577979,0.113675594,-0.017818866,0.064963125,0.08532438,-0.024555473,-0.058983196,0.020224651,0.047073547,0.033003755,-0.039082486,-0.032286398,-0.11454978,-0.123223215,-0.00012374023,0.08285604,0.015945721,0.058139168,0.038956672,-0.047071423,-0.06664091,-0.050289035,-0.00869342,-0.002655065,-0.03187071,-0.036384575,0.054275785,-0.023496743,0.032415267,-0.0045594,0.0015367432,0.025388494,0.03366254,0.08039244,-0.09166375,0.017319951,-0.029230371,-0.045363285,-0.015265066,-0.0071191234,-0.032426585,0.060905535,-0.0049563274,-0.02740687,0.021797698,-0.035754535,-0.056932207,0.045669433,-0.0951995,0.0030551194,-0.023945393,0.057174146,0.01841624,0.029697534,0.060362242,0.031323347,0.02210634,-0.027449526,0.0048379563,0.09805207,-0.03088067,-0.011411862,-0.058342636,0.03738088,0.04648879,0.0028937436,0.0022710932,0.007671599,0.0010699916,-0.017849099,0.11488192,0.015496509,-0.07352022,0.027415909,0.067592554,-0.08821523,0.022392549,0.05542887,-0.037209928,-0.014302238,-0.0050624423,0.07897356,0.07621572,0.014402767,0.07970999,0.01957117,-0.019614382,-0.0620781,0.03926193,0.030924115,-0.085069574,0.0062089902,0.105671436,-0.038963776,0.090711005,-0.078846246,2.8244321e-34,0.08018572,0.001537209,-0.009783568,-0.08114643,-0.04976409,0.0118988035,-0.022675592,0.06450058,-0.07959623,-0.009240359,-0.015276999,-0.12155356,0.103889726,0.04412751,-0.0037010524,0.0018064607,-0.048466604,-0.035759218,0.09982164,-0.054453183,0.034604784,0.009295632,-0.064228386,0.028445082,-0.001561994,0.037200764,-0.07112105,0.062161375,0.02217367,-0.023848122,0.04092341,-0.06627528,-0.105754405,0.0109044425,0.06578885,-0.05691811,0.037736937,-0.060411695,-0.06566447,-0.017334228,0.0007120127,-0.049736097,0.007396152,-0.048001718,0.059845947,-0.061358046,-0.083816014,0.031486623,0.10858489,0.05470558,0.070707485,0.012986592,0.13757928,-0.10025858,-0.048151087,0.0025114738,-0.0058463025,-0.079834886,0.017979706,0.058875747,0.029366817,-0.04306608,-0.042094227,-0.0679489,0.05459003,0.010646616,-0.0553875,-0.08718091,-0.004508815,0.04235502,-0.058280285,-0.0012934813,0.0076999897,-0.04045967,-0.021900868,7.071158e-05,-0.062934816,0.011977854,0.008574944,0.013066572,0.031242404,-0.0047554523,0.024388365,-0.0347768,-0.050843004,-0.007794739,0.04933041,-0.059039075,-0.02864757,-0.025356065,0.058461968,-0.10332698,-0.08222806,-0.009604053,-0.01841423,-8.971266e-34,0.029974367,-0.06524871,-0.012095668,0.010137024,-0.08214142,0.026400227,0.06616418,0.055382606,-0.025969222,-0.03378465,0.06385046,-0.029055659,0.06504052,-0.018804055,0.018209968,0.04843328,-0.05442269,0.05238769,0.02570516,-0.032084607,-0.039430834,0.09842175,0.08511182,0.1292169,0.1151629,0.03929426,-0.013510535,0.007533162,-0.002386873,0.07154139,-0.029160636,0.0038439147,-0.030354109,-0.04540165,-0.06229446,0.010713685,-0.062287603,-0.027736712,0.038519766,0.0131426975,0.050219007,0.021564694,0.06901368,0.030498916,0.034703005,0.028070409,-0.029308734,0.107837066,-0.02096539,-0.02671321,-0.0105596585,0.02838436,-0.0019942727,-0.04397325,0.08118183,0.07642503,-0.0037103747,0.009804729,-0.07344715,-0.01284031,-0.01087701,-0.006334535,0.04676241,0.034899894,0.07325938,0.08069685,-0.06458602,0.006355321,0.07259275,-0.044775292,0.058077954,0.047886815,-0.006350986,-0.025065323,0.0007591585,-0.0708425,-0.03523629,0.030196955,-0.014622979,0.014193755,-0.020953633,0.038785174,-0.035599813,-0.06483113,-0.0015195586,-0.03562608,-0.01783701,0.11299869,0.04862308,0.013280923,-0.06257901,-0.047561076,0.01238921,0.047570955,0.08701049,-2.2151735e-08,0.018157614,-0.0379933,0.08498127,-0.08638639,0.061356343,-0.02958566,0.02562092,-0.061518684,-0.032371935,-0.0069860145,-0.019315306,0.044460557,0.028767316,0.058516752,0.06609587,-0.008975781,-0.0032258308,0.015633151,-0.0281858,-0.016677355,-0.017386828,-0.058782034,-0.09968477,0.114222586,0.047875296,-0.06608915,-0.029480811,0.071365,0.012894361,0.0062057613,-0.008719709,-0.02705516,-0.0066724005,-0.07412722,-0.04252333,0.02973359,-0.043018963,-0.032594733,-0.049070492,0.003260212,0.010876525,-0.034499444,0.0012121558,-0.00026910135,-0.015083196,0.015924713,0.030666653,-0.008899311,0.009532128,-0.015021723,0.0020592483,-0.029946128,-0.041635353,-0.044867903,-0.058887318,-0.05680875,-0.0064266967,-0.05149238,0.056627903,0.021789698,0.013016279,0.017799858,0.17408189,-0.081658915 +3.1.3.16,"A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).",384,1.0,-0.062373675,-0.012706524,-0.0322892,-0.04211501,0.016155457,0.016283639,0.029681476,0.01503321,0.034915105,-0.011193024,0.04345317,0.08459301,-0.02934973,0.05444047,-0.018637216,0.027872872,-0.10354018,0.009082658,-0.008663278,0.0038258974,0.077869095,0.0066856313,-0.07009635,0.08353542,0.026039785,-0.051124018,0.012307573,-0.048671912,-0.08210359,0.08899938,-0.06097183,0.003716659,0.11586732,-0.027039975,0.030344026,0.12608333,-0.018895265,0.0029187328,-0.002513452,0.017067438,0.052953254,-0.035322692,-0.090297215,-0.07691671,-0.011794012,0.026371123,-0.033428293,0.035390038,-0.04626804,-0.0009774297,-0.11682516,-0.04648456,-0.065982856,0.045347348,-0.019851511,0.014432277,-0.07910772,-0.0020798808,-0.024747219,-0.04382454,-0.025207179,-0.02706087,0.04666632,0.07326103,0.10686683,-0.046696655,0.07154091,-0.040123545,-0.031666648,-0.011489495,-0.030269178,-0.068772115,-0.00625524,0.06558036,0.0048163855,0.008047601,-0.0318889,0.018351205,0.020613799,-0.054954983,0.07861123,-0.016911313,-0.057996087,0.055393197,-0.0028317021,-0.011998802,-0.041053507,0.0039445,0.049885478,0.012060498,-0.011413589,-0.10144873,0.07984751,-0.037169106,-0.03261773,0.041866254,-0.06815865,-0.0055114445,-0.018583504,0.017749166,0.0017428806,0.02583287,0.017932244,-0.04063386,-0.016845178,0.03370681,-0.076787055,-0.0035891803,-0.0055206395,0.031157417,-0.027542718,-0.014174076,0.083843835,-0.06438461,-0.0010280333,0.065657444,0.042479992,0.010000646,0.019842023,0.021183098,0.021640772,0.007556614,0.034143295,0.057058938,0.05399968,0.1033922,-0.11193923,1.1366457e-33,0.060737412,-0.0039354214,0.121124595,-0.04792733,0.027764838,-0.053895522,-0.007275608,-0.010090649,-0.03042086,-0.042554572,-0.023338998,-0.026231935,0.07154923,-0.023576535,0.018977547,-0.029777274,-0.040921737,0.07299583,0.092634335,0.05787795,-0.033130642,0.043554116,-0.020168394,0.03892368,-0.01135316,0.013572166,-0.0950855,-0.0648649,-0.01990548,0.013804939,0.058727052,0.015171525,-0.111035526,0.02460567,-0.027748985,-0.069415025,-0.08251051,-0.09640938,-7.4921874e-05,0.041400213,-0.07544893,-0.01914803,-0.059167445,0.017241182,0.036501065,-0.072304875,-0.06881851,0.1030186,0.0415926,0.06264023,0.02999928,-0.0657592,0.07078761,-0.026798714,-0.071896665,0.033567455,0.0051227016,-0.025327208,0.032361496,0.041492622,0.04111276,0.056590468,-0.020776192,0.0025195058,-0.0025321303,-0.06166261,-0.13011661,-0.048859008,-0.016682595,0.059139933,-0.036962092,0.022694787,0.023734413,0.06942093,-0.049562402,-0.015789004,-0.012308058,-0.061960194,-0.119925424,0.04146698,-0.02568335,-0.034241017,0.023005472,-0.011611592,-0.031557385,-0.05528386,0.0050183223,-0.063365884,-0.02963607,-0.08493667,0.0051200306,-0.054157253,-0.118973434,0.030241508,0.002591855,-2.9233555e-33,0.091633745,-0.06638575,-0.003931483,-0.044282652,0.0055851126,0.015724778,0.068981476,0.022217251,0.043561004,0.033774763,-0.03473162,-0.042688433,0.049767565,-0.07236346,-0.0062796,-0.008161105,0.025293374,0.0024540965,0.015550288,-0.016379505,0.024896905,0.03477879,0.013697015,0.10892718,-0.0045508775,-0.030311251,-0.08596641,0.10595987,-0.027458467,0.04959098,-0.027963512,0.016059747,-0.008405462,-0.018108543,0.021156576,0.013835112,-0.00843174,0.023367386,0.06936894,-0.0013600881,0.020886656,0.034273434,0.09353837,0.040080808,0.051932193,0.09743525,0.0006623735,0.041646574,-0.04633548,-0.08172494,-0.032219406,0.089229,0.02337708,0.047314152,0.018467799,0.00066775637,-0.05332016,0.03618741,-0.062929474,-0.026608152,0.0013668804,-0.052730773,-0.018998045,0.11283704,0.061910167,0.01980752,-0.0054049394,-0.0073221503,-0.032905843,-0.027597446,-0.017177425,-0.04789663,-0.0015129377,0.026155043,0.019001575,-0.054207318,-0.1318615,0.00051463005,0.04343749,0.0048423195,-0.0070914673,-0.052863736,0.021428486,0.006655209,0.016154764,-0.023039287,-0.022302948,0.06154421,0.006345782,-0.04020635,-0.031065434,-0.02897673,-0.043429404,0.022464657,0.0008603991,-3.9202e-08,0.15066686,-0.07279684,0.011853334,-0.02514831,0.04437637,-0.048526563,-0.026681708,0.095665365,0.06627827,-0.020224439,0.005105429,0.020202674,-0.023898073,-0.0061071743,0.11148321,0.048154604,-0.043826103,0.055270366,-0.052158788,-0.04534699,0.045978934,-0.019568099,-0.1272378,0.03505915,0.062902376,0.0053892713,0.023350326,0.023489486,-0.036682893,-0.025506254,0.014779778,-0.039893813,0.008697772,-0.004812099,-0.022930602,0.05188934,-0.07864505,-0.02481617,-0.0057259877,0.07393528,-0.04148073,-0.018793948,-0.041281242,0.013288051,0.03895112,0.030797055,0.03889325,0.013800905,0.017528819,-0.02496787,0.022041569,0.055579018,-0.08805977,-0.014977857,-0.11816872,0.015553941,0.042018868,-0.05341085,0.001155871,-0.069017276,0.09038977,0.1154818,0.18644224,0.0068802717 +3.1.3.21,"The Dunaliella enzyme acts more rapidly on sn-glycerol 1-phosphate than on the 3-phosphate. The enzyme from yeast also acts on propane-1,2-diol 1-phosphate, but not on a variety of other phosphate esters.",384,1.0,-0.046879843,-0.16454618,-0.014300891,-0.080320515,0.021243995,-0.030215671,0.0028970211,-0.0013855721,0.029927684,-0.04732772,0.021984627,0.05297331,-0.14231999,0.05623029,0.0032916435,-0.0519421,0.018313427,0.017579768,-0.013013561,-0.020672634,0.16652884,-0.029715862,0.02879349,0.027216313,0.0367752,-0.016977955,0.03035682,0.03562033,-0.004171329,-0.13000658,-0.06305986,-0.010006228,-0.007337481,-0.055445034,0.031163432,0.045639426,-0.03158112,0.040091217,0.069870934,0.02027582,0.08798289,-0.06640895,-0.0041006412,-0.018173277,-0.05138614,0.019529661,0.019091267,0.021802496,0.025643386,0.022238646,-0.091662265,-0.069415316,0.020368492,-0.113602124,-0.020114763,0.014421758,-0.051379856,0.05425396,-0.014103113,-0.041164037,-0.032155972,0.011636321,0.0015496181,0.036576305,0.050393865,-0.050416436,0.08846655,-0.08262452,-0.05671408,-0.0013472711,0.0025795293,-0.02739984,-0.03663643,0.017976355,-0.024046853,0.018970523,0.004739477,-0.0065175467,0.038761888,-0.0068959473,0.08481201,-0.020323666,0.04682071,0.0518319,-0.03796327,-0.038091265,-0.02016589,0.040763013,0.038785443,-0.037134018,0.032106195,0.035124257,0.041041374,-0.00038125165,-0.0016727636,0.0151520325,-0.04243629,0.035421614,0.008815664,-0.027022162,0.027514573,0.070511326,-0.0066004847,-0.047342703,0.029517803,0.118087344,-0.028149456,-0.024053782,0.04003114,0.082353204,0.013535006,0.038362645,0.084022716,0.01278289,-0.10646557,0.01516813,0.011683379,-0.00994219,-0.07051764,0.0009105594,-0.010127641,-0.08831715,0.029384833,0.051872317,-0.0649035,0.07805352,-0.06286303,8.861198e-34,0.01708378,-0.01942127,-0.033864837,-0.055751015,0.05141012,-0.025042616,0.0048648734,-0.023879282,-0.12622742,-0.016600026,-0.063992776,0.015820734,-0.0038825772,0.041658647,-0.06374632,0.032942206,0.11025906,0.025958138,0.0053054984,-0.01793676,0.053211167,0.004097566,-0.025870912,-0.026598005,0.06067697,0.003276937,-0.0068638804,0.08268346,-0.020420989,-0.03540361,0.07768835,-0.17410333,-0.030542063,0.03160404,0.11210484,-0.034589488,-0.021446072,-0.026360687,-0.0040986333,-0.016418338,-0.102777965,0.047463793,0.018382072,0.00015147186,-0.015168175,0.002611738,-0.050737556,0.07133298,-0.007409676,0.052291114,0.0285928,-0.041757885,0.052171778,-8.363022e-05,0.036009423,0.06991251,0.019018503,0.056730367,0.028108142,0.025117565,-0.0220239,0.072911605,-0.03292345,-0.038774367,0.041361347,0.070111185,-0.068165004,0.019249162,0.0988956,0.07013713,-0.027057765,0.054688524,-0.036756806,0.009526184,-0.001814964,-0.05458498,0.009018628,0.0009397448,0.01594534,-0.0134903835,0.0007128457,-0.024034884,0.04436198,0.016447516,-0.14569874,0.009567513,0.0008445705,-0.035005596,-0.04152254,0.009033588,0.11213133,-0.063646376,-0.010644205,-4.4741064e-05,0.017229633,-1.1551555e-33,0.06759702,-0.05704551,0.059330028,-0.0019378284,-0.0870426,0.06830884,0.065658465,-0.0565346,0.00026710166,0.008669644,0.01887043,-0.024090366,-0.00014093336,-0.06586809,0.0033892517,0.071290776,0.004671256,0.03558048,-0.01766648,-0.026233695,-0.032986023,0.16429815,-0.003305466,0.12669407,-0.05248045,-0.024897533,-0.008592188,0.09886271,-0.038085192,0.044670247,6.4286454e-05,0.03455334,-0.024986202,-0.103242986,-0.05620538,-0.0069767768,-0.041222725,0.031017818,0.0056245304,-0.013012239,0.019294722,0.034478877,0.040607397,-0.0055545443,0.014316496,0.07635834,-0.019780334,-0.059810605,-0.050526805,-0.044630397,-0.00033525648,-0.014670597,0.009162913,0.06574229,0.11366515,0.017512593,0.06288385,-0.027293207,-0.046135936,-0.039431863,-0.015265134,-0.09315574,0.030552777,0.024854964,0.045866437,0.09489477,-0.08444712,-0.016050726,0.1018511,-0.02552849,-0.029910056,-0.0060417294,0.04032597,0.05539488,-0.07961209,0.018359,-0.08497437,-0.018283263,0.026732352,-0.034946937,-0.012966819,0.00028639732,-0.07912627,-0.046386342,-0.012967322,-0.022927629,0.085965626,0.07226029,-0.011249441,0.04444599,0.0008710869,-0.031459037,-0.03695705,0.031636517,0.0600305,-2.996036e-08,0.084747694,0.009593154,0.07459212,-0.022641873,-0.040604353,0.016075298,0.07304411,0.06128468,0.05050941,-0.027228069,-0.09758505,0.06676767,0.04502684,0.0011677471,0.11344578,0.049413476,-0.00863584,-0.010192948,-0.040504232,-0.018795263,-0.021150269,0.039324816,-0.12048384,0.060865093,0.02251475,-0.01115428,0.012221641,0.050476756,0.015634807,-0.0020034271,-0.032290675,0.00850712,-0.017469522,-0.048639305,-0.07247302,0.018774094,-0.05441562,-0.017411197,0.043350715,0.049100243,-0.014081362,-0.04880205,-0.063035816,0.010484624,-0.0655139,-0.0042564305,0.06084688,0.00071201177,0.008439416,-0.010230716,0.0670053,-0.013046956,-0.074294455,-0.042439677,-0.07123316,-0.03890057,-0.011659012,-0.022627698,-0.013318891,-0.01001134,0.051926002,-0.038714092,0.09607059,-0.08967003 +3.1.3.23,"Has a wide specificity, acting on aldohexose 1-phosphates, ketohexose 1-phosphates, aldohexose 6-phosphates, ketohexose 6-phosphates, both phosphate ester bonds of fructose 1,6-bisphosphate, phosphoric esters of disaccharides, and on pentose and triose phosphates, but at a slower rate.",384,1.0,-0.032151625,-0.09334006,-0.0008420757,-0.015304725,-0.017450647,0.023726901,-0.0035500347,-0.04088949,0.099420354,0.049816,0.00518977,0.017577792,-0.07873458,0.0042162267,-0.0011858739,-0.017625377,0.013873975,0.061143637,-0.013830161,0.03600829,0.17786644,-0.03864193,-0.020428447,0.036081634,0.09625383,0.0014872381,0.04023312,0.010626207,-0.00037348736,-0.11521977,-0.06403406,-0.075568326,0.04736244,-0.019048668,0.039727785,0.1520384,-0.019572532,-0.052798867,0.03263033,-0.029737892,0.029133447,-0.08404026,0.03438778,-0.033936024,-0.0223784,-0.06927847,-0.061968736,0.090614475,-0.012537315,-0.02862036,-0.044300057,-0.0991446,-0.06899725,0.0123718735,0.104136854,-0.010520721,-0.09302322,0.10009817,-0.009118429,0.066045836,0.00090137357,0.018468363,0.005191842,0.06307757,0.00012326914,-0.006408232,0.026669517,-0.0115948925,-0.063872,-0.0037977386,-0.039327636,-0.0068997564,0.010192065,-0.036139764,0.057773404,0.030112077,-0.049002547,-0.000289727,-0.046864815,-0.057202917,0.043461513,-0.043792736,0.014552131,0.059304878,0.048269458,-0.044906624,-0.023722483,-0.006432079,0.0027563574,-0.01166446,0.020111548,-0.034390178,0.035714004,-0.045250718,-0.018574838,-0.00996335,-0.04233364,0.02128692,0.037121937,-0.026834015,0.015764084,0.054559384,0.0072545977,-0.037878145,-0.026035005,0.059879724,-0.08687835,0.058284987,-0.010521442,0.029543744,-0.06256215,0.022400698,0.042943273,-0.0061198636,-0.08784176,-0.0022809212,-0.05553449,-0.134589,0.045854717,-0.016652193,-1.6117068e-05,-0.03995173,0.051987022,0.07923913,-0.04615134,0.0230437,-0.07071155,4.9889582e-33,0.023772843,0.008075013,0.022862326,-0.019580921,0.0017797133,-0.022441301,-0.022347396,-0.0045475783,-0.08569785,-0.027859095,-0.027428245,0.027072247,0.09165979,0.024632918,0.023388725,-0.025322024,-0.0058300667,0.043872215,0.116456725,-0.00016102685,0.002911346,0.09415671,-0.057110883,0.01160531,0.007718997,0.02010496,-0.051256236,0.051378615,-0.042287584,-0.018948821,0.07349919,-0.006638213,-0.058985054,-0.024896374,0.014194907,-0.023406385,-0.08513309,-0.022369651,-0.05894033,0.023518153,-0.00016426682,0.03530365,-0.032738972,-0.0011793025,0.023629306,-0.032498375,-0.016604181,0.053485982,0.021813676,0.08694894,0.041695442,-0.020153278,0.008585315,0.0620442,-0.035387147,0.0535079,-0.032067493,-0.053895373,-0.017508168,0.03356167,-0.010156163,0.010156136,-0.016484665,-0.07597745,-0.0101355305,0.0043989317,-0.05781807,-0.015758822,-0.044860102,0.13342568,-0.079527155,-0.020160258,0.024593942,-0.010951663,0.028999414,-0.01682764,-0.050392613,0.026305532,-0.05256231,0.06415407,0.07926986,-0.038908277,0.021905122,-0.059131347,-0.13607165,-0.00039191617,-0.011335775,-0.110761285,0.011259355,0.08324577,-0.032207128,-0.06636245,-0.08633466,0.057307422,0.02960697,-6.504999e-33,0.10896391,-0.07279186,0.14143258,0.0076635582,-0.03520192,-0.006320784,0.03781595,-0.06809049,0.041040447,-0.051730186,0.07856369,-0.0065345145,0.030010294,-0.040146496,-0.020659726,0.059986997,-0.009927435,0.07477283,0.033394977,0.036270168,-0.027168473,0.11607541,-0.020918543,0.063235074,0.058890224,0.020712739,-0.011239632,0.027849806,0.023757463,0.027739128,-0.051739696,-0.04537415,-0.020602118,-0.04498915,-0.0785095,0.0131586725,-0.098598436,-0.007363586,0.014037698,0.019328386,0.041880846,0.073476255,0.081406265,-0.027820574,0.028909663,0.030109068,-0.021141395,0.013857643,-0.03953876,0.023607716,0.011347246,0.021327326,-0.05427462,0.080122724,0.08667825,0.01438867,-0.01597329,-0.020901782,-0.012882469,-0.024487667,-0.038551018,-0.035564676,0.056227367,-0.04085964,0.0990383,0.008406591,-0.06683383,-0.035544414,0.015858777,0.05686456,0.045268252,-0.04948519,-0.038961794,0.013248672,0.00965119,-0.02802409,-0.113661006,-0.008593457,-0.06656961,0.0037214987,0.029330561,0.032196276,-0.027745623,-0.04082048,-0.01398274,0.046852425,0.053205956,0.04187169,0.008158764,0.027712489,-0.04003452,0.0033229298,0.052401323,0.024316838,0.06091082,-4.1989782e-08,0.023395928,-0.07236146,-0.0019063425,-0.034640484,-0.0074205,-0.01460248,0.04040956,0.011246569,-0.053483583,0.019461857,0.01148599,0.15679193,0.023386838,-0.019561818,0.05736968,-0.060977817,-0.09606149,-0.038400333,-0.015531751,-0.014797335,-0.060369715,0.014158691,-0.07744928,-0.002506494,0.04247095,-0.04088984,0.03709104,-0.05247537,-0.010013408,0.07550963,0.004334361,0.015338523,0.02556242,-0.12005211,0.022334078,0.06561326,-0.066536546,0.01978053,-0.046249263,0.021139558,0.00025912325,-0.090387315,-0.042630266,0.032074098,-0.001230817,0.059923586,0.015043859,0.064052105,-0.06614517,0.032103203,-0.013915049,0.008274753,-0.111720696,-0.069094,-0.039965577,-0.027985662,0.024334082,-0.03161803,0.04215589,-0.040619574,0.066500224,-0.02796044,0.20326841,-0.036030468 +3.1.3.24,"Requires Mg2+ for maximal activity [2]. This is the final step in the sucrose-biosynthesis pathway. The enzyme is highly specific for sucrose 6-phosphate, with fructose 6-phosphate unable to act as a substrate [2]. Belongs in the haloacid dehydrogenase (HAD) superfamily. The F of sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.",384,1.0,-0.04951046,-0.05176954,-0.0830806,0.0034423526,0.061188348,0.002665326,-0.084597975,0.0019622764,-0.017884107,-0.0021555608,-0.011998138,0.05767971,-0.033664484,-0.032653946,-0.037145115,0.0073977965,-0.052624658,0.024146464,-0.055992603,-0.040366855,0.16415833,-0.015865777,-0.010179172,-0.038325578,0.067631245,0.019480858,0.075645074,-0.042847857,0.0156991,0.0068374216,-0.020264903,-0.024360912,0.052792195,-0.025060192,0.056834407,0.14985256,-0.044706594,-0.042717382,0.026312789,-0.054254256,-0.025213974,-0.04678564,0.027772257,-0.022007078,-0.0136234565,-0.081937455,-0.020182258,-0.0070029628,0.014990918,0.020342475,-0.051943686,-0.053685006,-0.0467473,-0.00019752842,0.050385166,0.04921466,-0.09135316,-0.024792861,0.00030969345,0.011775223,-0.023350444,-0.0050527626,-0.029421225,0.002584903,0.04347431,-0.041486397,0.022279011,-0.06754506,-0.02792383,-0.025251593,-0.024622224,-0.04331004,0.019322325,0.0071308147,-0.0013287512,0.022856548,-0.019194178,-0.060863566,-0.016376369,-0.02241829,0.08032164,-0.012443277,0.09794212,0.06760215,0.052705605,-0.038049657,0.06712587,-0.0018677418,0.029267045,0.10017246,0.031866252,-0.00587014,0.010828985,-0.052915663,-0.036636725,0.043530185,-0.044070747,0.03218903,0.04483764,-0.038423996,-0.009846361,0.043633584,-0.0026836637,0.012780834,-0.026397262,0.03112356,-0.043765947,0.10397624,-0.031957075,0.017629888,0.050859716,-0.0014851788,0.05297144,0.063908294,0.012686592,0.094574265,-0.0333138,-0.11388304,-0.045097385,-0.023003401,0.040135764,0.07331636,0.06901332,0.07800813,-0.04442063,0.07120049,-0.121631846,2.8253042e-33,0.03906356,0.030642562,0.047852643,-0.052913636,-0.038811162,-0.003465063,-0.06622662,-0.0070811505,-0.075288534,0.06041406,-0.06268651,-0.032933485,0.036165934,-0.045749836,0.009771952,-0.042650253,0.030846613,0.02962377,0.09208846,0.027220897,-0.040630464,0.057772942,0.02274874,-0.07832208,0.014757502,0.082031,-0.021557279,-0.0011107544,0.046382524,0.0066866395,0.081321344,-0.1050595,-0.007966746,0.022531468,0.087560914,-0.030569907,-0.051896136,-0.024538394,-0.07403942,0.023551017,0.002322563,0.06421977,-0.030325757,-0.011015356,0.011024783,-0.05157642,0.002238063,0.062942,0.05766883,0.10456695,0.026806623,0.0048973504,0.07736431,-0.013905392,-0.033262294,0.024737217,-0.012838974,0.013904006,0.072395876,0.023855258,-0.015225832,-0.029641379,-0.020617213,0.055897143,0.07973203,-0.030172518,-0.13169073,-0.025162108,-0.030457167,0.12586835,-0.05681793,-0.07312708,0.036090106,0.027065512,0.051498603,-0.015986403,-0.030053642,0.046540026,-0.06430186,-0.008393216,0.03755373,0.023064926,-0.04148751,-0.06815304,-0.07522055,0.06667134,-0.08118467,-0.118172355,-0.032414727,0.051938977,0.0024641799,-0.052014522,-0.0369968,0.04520002,0.06294587,-3.7594785e-33,0.09114473,-0.049564812,0.044590063,-0.063036025,-0.02698361,0.06570371,0.079552956,-0.13786097,0.042595256,-0.010156967,0.07196474,0.023975091,0.028858615,-0.08788136,0.028967367,-0.0051862486,0.010724525,0.08075185,0.01735186,-0.008282836,0.009484619,0.13232818,-0.014786643,0.036043264,0.04540998,0.015730409,0.052749127,0.02552686,0.028718952,0.028138585,-0.032156903,0.057849806,0.008071577,-0.026471358,-0.0897009,0.005302606,-0.07486762,-0.004444087,-0.003055038,0.05165993,-0.044076666,0.06973866,0.04970114,0.05045844,0.031121014,-0.014164578,0.0030687663,0.061705574,0.021580849,-0.08066685,-0.015983915,-0.08774702,-0.03590714,0.020406056,0.07494919,0.013551054,0.013753017,0.000648063,0.03456956,-0.061833676,0.046048064,-0.017587915,0.056373622,-0.03655164,0.058815204,0.02305856,-0.02821407,0.020167412,-0.044772487,0.033656962,-0.021695886,-0.037677117,0.015985848,0.04499541,0.004737274,-0.0152301695,-0.09518023,-0.017435301,-0.009893211,0.010383385,-0.026116177,0.09602722,-0.054183714,-0.033059537,-0.014359544,-0.14560272,0.021014094,0.055757742,0.010728631,-0.008661938,-0.107617795,-0.041260675,-0.024096001,-0.006087291,0.008738285,-4.1355623e-08,-0.030252226,-0.089763954,0.0027691706,-0.056547534,0.056171235,0.025917226,-0.007547285,-0.024649352,0.009024381,-0.010686587,-0.002220599,0.04773907,0.03746329,-0.028385581,0.008848,-0.033654165,0.0032618637,0.029709151,-0.03593487,-0.020482335,-0.058357954,-0.052444886,-0.10129159,0.05938589,0.025215933,-0.056305338,-0.0071165524,0.03031429,-0.008640127,-0.0035334623,-0.0075248876,0.013332847,0.05454928,-0.05803135,-0.06010156,0.050330542,-0.030748628,-0.0133914035,-0.03999314,-0.011539115,0.013839982,-0.021937583,0.03200402,0.024741028,-0.07485508,0.08028765,0.040046066,0.034668725,-0.07996918,0.07480124,-0.018512482,-0.09524472,-0.08406732,-0.015808543,-0.0042554713,-0.018545464,0.056623045,-0.08858491,-0.021380879,-0.057501588,0.06665731,0.05177762,0.175532,-0.09155804 +3.1.3.25,"Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. It also acts on adenosine 2'-phosphate (but not the 3'- or 5'- phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate. Two isoforms are known [4].",384,1.0,-0.056831367,-0.16781485,0.023246177,-0.055362232,0.01726004,-0.048753854,0.06923652,0.00018574059,0.037886817,0.03157004,0.07173486,0.016872918,-0.06515913,0.066022344,-0.026402632,0.03389703,-0.04593223,0.036232058,-0.0016293215,-0.053587712,0.114865944,0.005355478,-0.036669567,0.011949536,0.025485735,0.0039763763,0.00788082,0.083080694,-0.016645338,-0.11912056,-0.09347477,-0.06337623,0.0059457966,-0.03978924,0.059028473,0.105379626,-0.07115307,0.0019506583,0.029965222,-0.017601851,0.09007408,-0.11652036,0.04342158,-0.024176812,0.018858476,-0.034495994,-0.046450693,0.00661848,0.025887787,0.038629416,-0.053249244,-0.083650075,-0.040413756,0.012663144,-0.04548236,-0.03167246,-0.10854738,0.09686632,-0.0047933348,0.0008747475,0.023853548,-0.047628447,0.026217071,0.071218066,-0.0024960805,0.032081336,0.05403386,-0.014442271,-0.07438614,0.015574668,0.001553805,-0.025101012,0.04541893,0.05146627,-0.008483676,0.006190566,-0.08603572,0.019190412,-0.013079161,-0.011247669,0.0027566233,0.0022484567,0.014336689,-0.012099091,-0.01261851,0.021170532,-0.050642166,-0.006036577,-0.035834804,0.04276452,0.022570759,-0.01727112,0.04224519,-0.04292281,0.05595581,-0.02737871,0.05061294,0.007158707,0.014473584,-0.041191638,0.021739844,0.007280918,-0.13562225,-0.065943465,0.046841614,0.054464564,-0.08610278,-0.09019886,-0.01132737,0.06249784,-0.097907454,0.017975902,0.05015682,-0.031247156,0.008714527,0.07408802,0.0019539047,0.025192115,-0.019550534,0.043659225,-0.028438015,-0.094418794,-0.002802798,0.074661985,-0.12500961,0.05599824,0.021105845,2.7720359e-33,0.039548125,0.009720478,0.02453696,0.058512703,-0.018378101,-0.039692707,-0.030824397,-0.017980816,-0.106411636,-0.024802847,-0.052501403,-0.014456652,0.057461426,0.030625073,-0.031755723,0.07171975,0.028322339,0.040917274,0.07647958,-0.04692038,0.009747908,0.088189006,-0.06628451,-0.01846026,-0.02771513,0.060553875,-0.09613946,-0.0036716585,-0.013163412,-0.025485063,0.06448784,-0.060566545,-0.07169865,0.03526571,0.050467476,-0.05827734,-0.06822149,-0.017098181,0.028285535,0.010740659,-0.036387194,-0.016455721,-0.019426564,-0.015125927,0.085654944,-0.014448925,-0.0039525754,0.0018484765,0.024690665,0.022152722,0.044625316,-0.04609966,0.034306623,-0.06972501,-0.028248284,-0.027553312,0.024344945,0.013800469,-0.012929472,0.06436399,0.016318562,0.026972085,0.008480495,-0.040862877,-0.052852612,0.008476884,-0.14591244,-0.013331514,0.016179726,0.06837016,0.04288126,0.0040692957,0.008904407,0.009657497,0.058136087,-0.00764992,-0.0061880937,0.00813236,-0.07626334,0.030816277,0.014787525,0.009406802,-0.008864363,-0.010240876,-0.034915227,0.04842806,-0.0012102235,-0.08649221,0.009706288,0.044527832,0.05852885,-0.045515087,-0.07873627,0.018200861,0.029586012,-5.4687076e-33,0.06444164,-0.02357771,0.1338816,-0.04370457,-0.07235787,0.031869065,0.04238471,0.012698301,0.06845899,0.07772058,0.054142747,0.0031387075,-0.0039656092,-0.028779576,-0.053288396,0.044098202,-0.031275656,0.031023158,0.04179636,-0.01868726,-0.04675011,0.078342,0.047496993,0.13369523,-0.010787974,0.02438762,0.0030844798,-0.03882431,0.076206274,0.10738739,-0.0005320403,-0.03878231,-0.052238192,-0.037528597,-0.0027059037,-0.03518675,-0.08728084,0.033874482,-0.052536037,-0.09037441,-0.012199167,0.052695654,0.10287988,0.015454295,-0.036093727,-0.0049573914,0.016803984,-0.00862156,-0.14279857,-0.03169355,-0.0981363,0.012705855,-0.04207651,0.055994675,0.10983182,0.08881241,-0.0021012612,-0.00053651456,-0.027752401,-0.03665698,-0.032429416,-0.054181904,0.003329434,-0.053459615,0.06822766,0.07092547,-0.01669806,0.0074524134,0.015941994,0.006437382,0.00070714,-0.09246343,0.0031650846,-0.0153523,0.0046863127,-0.050088428,0.0047097476,-0.02446647,-0.034438018,-0.029216358,-0.0314173,0.029817961,-0.051033795,-0.044758197,-0.016517019,-0.016045565,0.073026665,0.11631402,0.017150853,0.05994382,0.076765664,0.12260811,0.014496411,-0.010472414,0.02602415,-4.400942e-08,0.084735386,-0.06285978,0.11882343,-0.08934076,-0.049522996,-0.020995226,0.009913842,0.063081406,0.04774648,0.005068084,-0.014935145,0.0335197,0.08031874,-0.08074675,0.076291405,0.012578413,-0.07746714,0.039054,0.0017638386,-0.07525416,-0.08007933,-0.036987964,-0.060801975,0.016094297,0.01763293,0.006791367,0.03968539,0.056148544,6.013301e-06,0.0105103,0.03992345,-0.03701594,-0.017002527,-0.019638585,-0.06209611,0.044787057,-0.038602665,0.00511394,-0.067417644,0.015337824,-0.03179621,-0.111848496,0.014641527,0.070795804,0.0054870746,0.075462416,0.005972254,-0.015630491,0.030632278,0.015939957,-0.060965218,-0.04821582,-0.044459753,-0.026113098,-0.035335474,-0.0072212107,0.048164666,0.0367071,0.040182173,-0.01679463,0.03719785,0.01729408,0.048981074,-0.033443063 +3.1.3.28,"Also acts on 2,3-bisphosphoglycerate.",384,0.99999994,0.07045139,-0.107172035,-0.034663808,0.025504705,-0.025624601,-0.056415606,0.09011334,0.017211946,0.057714354,0.01776527,0.0030565404,-0.04789411,-0.02993948,0.071447305,-0.0095450515,0.00040020127,-0.053311553,-0.013535519,0.0020239877,0.041741364,0.120420404,-0.0134829115,0.064222895,0.018504005,-0.016926521,-0.036172464,-0.0025280335,-0.0042009563,-0.013237597,-0.07623654,-0.040862586,0.011948037,0.012410321,-0.048185613,0.03504474,0.06283868,-0.05148343,0.032593176,-0.017127099,-0.00011526069,0.04430925,-0.045576777,0.006112878,-0.028572848,-0.014673435,0.029683894,-0.037085876,0.023250781,0.055941723,0.042181138,-0.07405394,-0.09345397,-0.04337348,0.1453649,0.0059935967,0.05315669,-0.079513304,0.094555005,0.012841109,0.0016352339,0.001711167,0.02173586,0.020802548,0.043524317,0.09358964,0.01733085,0.020795325,-0.100086,-0.018158339,0.007448424,0.03652096,-0.028593654,0.054517955,-0.031214358,0.013020583,0.04033897,0.02249037,-0.044403356,-0.0015847946,-0.043462973,-0.065127544,0.0015173543,0.04207581,0.0042790314,-0.018985426,0.019335333,-0.02778494,-0.098695554,-0.09772038,0.026611181,0.014092781,-0.019889338,0.097761445,-0.041129813,-0.015363904,-0.0067522535,-0.0049320683,0.02398132,0.012149024,0.0008686064,-0.014019684,0.097308785,-0.007919622,-0.039134964,0.014078291,0.05027166,-0.055840824,-0.049235526,-0.017724523,-0.016836766,-0.0058700764,-0.011797765,0.08376793,0.049091414,-0.018527152,0.11650881,-0.013276577,-0.036961757,0.02943227,0.0013234047,-0.0011547195,-0.07464272,-0.04439953,0.0082794465,-0.05757628,0.07966909,-0.080437295,-1.4762727e-34,0.07360774,0.018334467,0.017334897,0.03695046,-0.0067994767,-0.017009618,-0.07526251,-0.08079812,-0.030217899,0.012129295,-0.009452304,-0.08257715,0.076596364,0.057405487,-0.006152492,-0.027682213,-0.021852806,0.012154871,0.033175725,-0.042513717,-0.014084744,0.12150763,-0.0896336,-0.10149327,0.033639353,0.07359559,-0.023480378,0.040386472,0.0018196199,0.0038869148,0.07929477,0.039967906,-0.076892965,0.047798336,-0.018008122,0.024126166,-0.007039603,-0.041151218,-0.067024335,0.0455847,0.05291867,-0.0158648,-0.026308123,-0.021118937,0.08786795,-0.08695447,-0.074025005,0.059989713,0.10098346,0.04582467,0.10250335,0.014442674,0.11188177,-0.0059001707,-0.020652752,0.013731118,-0.0009494625,-0.065299965,0.04758373,0.06617953,0.01683731,0.049244698,-0.003910681,-0.021819862,-0.058503922,0.019338649,-0.11208357,-0.0596151,-0.039499138,0.030636644,-0.07129342,-0.0137844905,0.1175339,0.0065290774,-0.016367644,-0.028718326,-0.015483643,-0.043196026,-0.039705377,0.07247384,0.025689816,-0.09049047,0.07174554,0.010173466,-0.07977351,-0.010339221,0.040630158,-0.16663995,-0.052874207,0.04236691,0.029329117,0.00241862,-0.07525097,0.01802859,-0.07326421,-1.2236999e-33,0.03612866,-0.06621297,0.0132187605,0.0055042994,-0.060297273,0.022575239,-0.02968922,0.016615221,0.022874359,-0.03873824,0.10108212,0.0028256013,0.02303222,-0.062486082,0.06796764,0.060039587,0.071931824,0.0072742477,0.0032632516,0.019540688,0.039285887,0.09385897,0.0077453996,0.07259449,0.03932937,0.04080774,0.04336169,-0.039423008,-0.014535881,0.031308405,-0.044905327,0.010630081,-0.058707315,-0.08890235,-0.067159005,-0.029085726,-0.05566624,-0.051996917,-0.030872319,-0.061430946,-0.012849049,-0.0608433,0.09618166,0.13891992,0.02575464,0.02017113,0.068320334,0.05620916,-0.027104493,0.07244833,-0.027682906,-0.08448806,-0.00381792,0.058783945,0.10170487,0.047844164,-0.048756007,-0.06997222,-0.050683238,-0.03359652,0.008122631,0.03155561,0.01408415,-0.027237495,0.12970087,0.056677688,-0.11425384,-0.027399393,0.019420672,0.03696798,0.048277467,-0.022632178,-0.02771667,0.010051554,-0.05616996,-0.040634874,-0.07017504,-0.03189799,-0.0095141195,-0.026104355,-0.0607826,0.04706425,0.05471028,-0.027614078,0.027389718,-0.06816792,-0.062831014,0.05398772,-0.013809487,0.0041662217,-0.055806976,-0.0064336746,-0.024285829,-0.024528544,0.049283072,-2.163592e-08,0.05505254,-0.013140907,0.010781502,-0.062312074,-0.02989552,-0.023615703,0.07597133,0.03488073,-0.03195336,0.007045002,-0.036219966,0.06499968,0.09230577,-0.053450458,0.11326236,-0.010097247,-0.0007580177,0.019605948,-0.08497678,-0.051276583,-0.094507195,-0.084017955,0.011874059,0.031351876,-0.010634271,0.0083907945,0.0022176611,0.012289984,-0.010838772,0.012921076,0.0421717,-0.044799294,0.016649611,-0.04557052,0.00017394515,0.048403367,-0.019603856,-0.015563356,-0.057038143,0.012016169,-0.0041963514,-0.027657164,0.007561012,0.065531135,-0.05339331,-0.03661177,-0.033680424,-0.0018609422,0.02492613,-0.038687482,0.053807482,-0.019706236,0.011546713,-0.006895803,-0.07994504,0.00720708,0.016971948,0.0046025584,0.06339197,0.04301989,0.09391371,-0.023865402,0.092996255,-0.023709748 +3.1.3.29,"The enzyme, found in vertebrates, is equally active with N-acetylneuraminate 9-phosphate and N-glycoloylneuraminate 9-phosphate.",384,0.99999994,-0.022286871,-0.08784782,-0.07245673,-0.031876042,-0.02931966,0.042050716,-0.053661793,0.059727862,-0.029512415,-0.020433482,0.019483669,0.03800259,-0.06061335,0.07804361,-0.089784905,0.0033472218,0.012477171,-0.022950944,0.0044679316,-0.022729581,0.066421196,0.05476004,0.03007438,-0.08524082,0.07295603,0.0065258467,0.024830094,-0.039020192,0.025512686,-0.06676294,-0.042204082,-0.03433435,0.019046508,-0.035590913,0.04330011,0.076521255,-0.08363339,0.024739895,-0.013159609,0.03557555,0.030249007,-0.06391089,-0.036466345,-0.019372653,-0.024714673,-0.032226186,-0.036677536,-0.04470678,0.028204279,0.072393514,-0.072169274,-0.08913965,-0.020751325,-0.018281711,0.0579338,0.02281085,-0.08528148,0.039247647,-0.017261727,-0.018457323,0.06004213,0.025238454,0.04644337,-0.0036781775,0.079790495,-0.043927345,0.11902886,-0.049777746,-0.08570003,-0.024330743,0.043364532,-0.027161375,-0.005460854,-0.071974985,-0.069203556,0.035975333,-0.071424775,0.021039926,0.03430099,0.00528872,0.07441078,-0.019346133,0.003580543,0.06727236,0.051465712,0.017996116,-0.016713573,0.06461089,-0.005572747,0.011378532,-0.019249879,-0.019420933,-0.025656903,-0.06285134,-0.05504307,-0.011374736,-0.02976417,0.07331878,-0.047388617,-0.030033795,-0.004551784,0.0656023,0.02906714,-0.02777441,0.0090498375,0.09925684,-0.038280144,0.046157658,0.07382341,0.0064467858,-0.064099,0.05222779,0.02824766,0.005922961,0.030513171,0.064102635,-0.07399776,-0.04341845,-0.038184356,0.03210467,0.031241447,-0.039686307,0.048644956,0.019163966,7.0219453e-06,0.07031246,-0.051096063,9.054813e-34,0.10450705,0.021240845,0.005154947,-0.035382446,0.04054121,-0.004211736,-0.1011258,0.09049785,-0.05763868,-0.04639003,-0.00803567,0.008756848,0.051129606,0.012946999,0.02949917,0.05111799,0.010497703,0.0057851933,0.07258794,-0.027630812,0.09217684,-0.017710678,-0.036092274,0.061875246,-0.02013479,-0.01567616,-0.027036238,0.051108193,-0.0069862376,-0.010706033,0.02463054,-0.17918022,-0.069710486,-0.0062858104,0.044240363,-0.04287107,0.024254363,-0.08221462,-0.007196854,0.010665569,0.001744824,-0.008215424,0.04201142,-0.032844294,0.057287466,-0.052960914,-0.061678525,0.028024456,-0.007873156,0.051719684,0.049170148,-0.05427275,0.13105473,0.02112875,-0.043275453,0.0534589,-0.024477553,0.014007068,-0.02476707,0.04232061,0.03265443,-0.06108401,-0.020515995,-0.01524909,0.01155556,0.023758925,-0.08902981,-0.04214581,0.028268842,0.05515937,0.028408438,-0.042184774,0.0065970826,0.02516761,-0.01612545,-0.061715852,0.023244368,0.03892025,-0.012210052,-0.0015355429,0.02294778,-0.014398741,-0.037037335,-0.046527773,-0.04013606,0.04098101,0.0504816,-0.14593926,0.005382678,-0.005102643,0.07969658,-0.07366152,-0.10447882,-0.034399975,0.03283033,-1.7178357e-33,0.11781825,-0.04057041,0.02926157,-0.0060639726,-0.0784955,0.08599308,0.0127903195,-0.030288707,-0.052801497,-0.07173911,0.03340684,-0.0048896456,0.07717242,-0.088547155,0.0552534,0.024360728,-0.016116073,0.060773484,0.07467166,-0.019826919,-0.02120406,0.05425727,-0.011886308,0.032040972,0.05523842,0.015980147,-0.051459942,-0.002398994,0.0361118,0.06805774,-0.048437916,0.034473013,-0.04117982,-0.009220014,-0.06374926,0.09485533,-0.010304257,-0.00036575136,-0.015756218,0.022698237,0.074185275,0.09521398,0.03793229,0.07121943,-0.009753063,0.0838484,-0.022950053,0.01717183,-0.013011986,-0.08972839,0.066829264,0.020589452,-0.031695038,0.034486562,0.0664173,0.10995641,0.018349,0.044443898,-0.053734593,-0.028384503,-0.0008192533,-0.021527652,0.005441847,0.0015432278,0.0049403044,0.07797647,-0.008147829,0.0729941,0.01198213,-0.015539492,-0.071756855,0.0098435115,0.038109157,0.0646913,-0.015246646,0.01907137,-0.033318345,-0.014604319,0.00656232,-0.044808477,-0.015545384,0.03238583,-0.03544513,-0.10890049,-0.04776971,-0.051476743,0.029747551,0.12825823,0.040792845,0.006711556,-0.042181615,0.008048093,-0.110610515,0.0015974835,0.035551824,-3.2635864e-08,0.08197623,-0.036043566,0.05530172,-0.13232028,0.040273402,-0.05510918,0.058152806,-0.009016412,0.048797667,-0.019474952,-0.028055528,0.030247897,-0.049301323,-0.019479223,0.046533946,0.043240916,0.0003955169,0.017837223,-0.04701492,0.039064176,-0.09232393,0.030154428,-0.042650506,0.061726082,-0.03155647,0.004668159,0.009570856,0.010340431,0.019464873,0.046138085,-0.052768763,0.040371556,0.022105223,-0.14794269,-0.069478855,0.010623569,0.027574316,-0.028080646,-0.040141754,3.8888586e-05,-0.01342586,-0.07847569,-0.047298484,0.007843085,-0.015103454,0.03730726,0.03968741,0.01784821,-0.0108522605,-0.055811435,-0.02537528,-0.025148973,-0.03644295,-0.09661635,-0.14360371,0.008359602,-0.011251263,-0.03612125,-0.014406196,-0.05706492,0.024951208,0.02421061,0.18224727,-0.093193874 +3.1.3.31,"A wide specificity for 2', 3'- and 5'- nucleotides; also hydrolyses glycerol phosphate and 4-nitrophenyl phosphate.",384,1.0,-0.04492907,-0.12328693,-0.025770864,-0.102919266,-0.056430716,-0.043628033,-0.046519473,0.04177456,-0.017058045,0.031157048,0.015949154,0.028516216,-0.12145757,0.06585369,-0.07905791,-0.0034572992,-0.070618466,0.049678575,0.0114631485,-0.034562528,0.09742855,0.07014156,-0.018110175,0.0149917,-0.044154637,0.052509345,0.01618173,0.028191907,0.027815143,-0.057116143,0.007269555,-0.088262565,0.03297487,-0.069634825,0.07630268,0.05272456,-0.021140613,0.018599452,0.004131517,0.055966027,0.10308384,-0.03369824,0.029300809,0.07276776,-0.040987108,0.0064714523,-0.02953507,0.029730786,-0.02516471,0.042423297,-0.016040102,-0.06536048,-0.069035865,-0.026571058,0.003587862,-0.015821053,-0.089354046,0.044180553,-0.0048478935,0.060945693,0.02156635,0.006337252,0.022776185,0.00045159296,0.05247423,0.006566808,0.08740088,-0.058107812,-0.04524961,0.05244469,0.03509993,-0.018409984,0.014847606,0.015805233,-0.06512204,0.02697743,-0.05824583,-0.03874636,0.021940466,-0.050974466,0.025955908,0.020383837,0.02668272,0.079543166,-0.01392004,-0.010236033,-0.041782603,0.044974905,-0.029037518,0.0067467378,0.0164062,-0.046104867,0.031804476,-0.040775374,-0.044012938,0.0057358993,0.007790442,-0.033240747,-0.00045100565,-0.05344127,0.029912049,0.05316516,-0.022590315,-0.040310122,-0.0010281779,0.08285348,-0.03800098,-0.0015677047,0.049967237,0.0382417,-0.054168344,0.07512041,-0.004001692,-0.0041796146,-0.028184526,-0.03543409,-0.04035346,-0.023416003,0.02095968,0.0079662595,0.007706373,-0.07382316,0.04047669,0.020606937,-0.0937079,0.07609624,0.00059505476,1.3629311e-33,0.031049952,0.037230875,0.020278638,0.02533481,-0.015386121,0.038538534,-0.067224994,-0.00324586,-0.13562658,0.013420977,0.017634982,-0.014885818,0.08551834,0.025495492,0.018233705,0.028672172,0.005049459,0.070505336,0.048598915,-0.054460324,0.02053962,0.075473234,-0.026577916,0.010243053,0.07946513,0.0063170725,-0.07774339,-0.011296206,0.12275838,-0.037747182,0.04647943,-0.1220004,-0.045672372,0.0035705173,0.09085365,-0.058775634,-0.053234674,-0.06886723,0.055044077,0.057816632,-0.017779125,-0.012608845,0.047508392,-0.014982086,0.057138618,0.022113072,-0.021576177,-0.0016983167,-0.025407545,-0.013423017,0.019860331,-0.014384886,0.06498512,-0.015148016,-0.004614326,-0.014387913,-0.015971351,-0.0017457547,-0.0265913,0.018990057,0.007680064,0.09098683,0.020067172,-0.06543793,0.033791088,-0.021113839,-0.08149673,-0.069873765,0.053633388,0.091182925,0.02912257,-0.06844081,0.108206674,0.022615835,-0.040632483,-0.016318161,0.056842394,0.03268521,-0.08098719,0.106075205,-0.025134481,-0.01611601,-0.015411845,-0.025461089,-0.05373635,0.016122835,0.03933816,-0.109809145,-0.027307414,0.038111996,0.07123049,-0.08881663,-0.052560743,-0.060767997,-0.066948034,-3.2498198e-33,0.05798483,-0.029035507,0.046195045,-0.0069513456,-0.08953849,-0.015500525,0.039519127,0.011544316,0.02616312,-0.021470161,0.084947154,0.052357957,0.04027693,-0.05667175,-0.007907734,0.03794105,-0.012952445,0.05987099,0.022947507,-0.034644898,0.0785674,0.050271757,-0.011144458,0.08588014,0.08987351,-0.007085201,-0.019194828,-0.02744647,-0.017142754,0.07105258,-0.056710638,0.016020821,-0.030339252,-0.042799164,-0.007552271,-0.02914523,-0.046836503,0.0021396484,-0.029784055,-0.038706403,-0.018684758,0.13232076,0.08355633,0.03748037,-0.003579202,0.068031944,0.007353826,0.03358925,-0.020584738,-0.031568553,-0.03585467,0.021404155,-0.07612546,0.059568223,0.064461105,-0.029073978,-0.03261234,0.021747554,0.019887011,-0.02939124,-0.051172383,-0.12690295,0.03370923,-0.06997368,0.019008882,0.08556493,-0.013396251,0.004377704,0.031837065,-0.031053223,-0.04392944,-0.050090145,0.12166186,0.04550556,-0.056523457,0.007858481,-0.037203018,-0.072183274,-0.023570063,-0.04591701,0.00456324,0.025241377,-0.02016885,-0.0061081746,0.03333569,-0.06442025,0.09203175,0.14953122,-0.0045805257,0.021369625,0.012177138,0.014625344,-0.03306935,-0.009260099,0.017416658,-3.172807e-08,0.09151122,-0.053849533,0.045407712,-0.118800454,-0.028879633,0.033962194,0.0241031,0.07768402,0.060703497,0.039988264,0.0014797071,0.035365433,-0.021460818,-0.028188623,0.067675866,0.04497149,-0.09497048,-0.03389354,-0.034181666,-0.02901618,-0.092958555,0.059761904,-0.12626696,0.073078394,-0.051193975,0.048059676,0.03894072,-0.015470413,-0.009915249,0.0006248986,0.062760845,0.009007761,0.046541147,-0.098347,-0.0068776184,0.023359112,-0.045544747,0.050782338,-0.058113385,0.03387349,-0.06347053,-0.06802312,-0.009682923,0.06795008,-0.01964643,-0.012901463,-0.029578228,0.086916625,-0.05730805,-0.03318654,-0.017584767,-0.053315647,-0.024437634,-0.071377344,-0.061062552,-0.05006055,-0.016560461,-0.025148384,-0.077947184,-0.015288438,-0.019461961,-0.012520874,0.16504481,-0.0102579715 +3.1.3.32,"Also hydrolyses nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.",384,1.0,-0.009219264,-0.11348928,-0.011610792,-0.099357404,-0.032575395,-0.03256573,-0.03188154,0.046906423,-0.0018771999,0.0536443,0.008120608,-0.0065333094,-0.077004164,0.0701247,-0.039422825,0.010166205,-0.10627133,0.0509527,0.05364985,-0.0091182655,0.11508746,0.024017606,-0.014929564,0.052811615,-0.001916005,0.05285562,0.0024024532,0.018819176,0.027142968,-0.059733093,-0.056270998,-0.0569452,0.017060244,-0.072988,0.10337531,0.08008596,-0.02889801,-0.00030667367,0.037813514,0.030106544,0.09470928,-0.034934063,0.072121456,0.052364126,-0.061505504,0.013829119,-0.042930283,0.024776852,-0.009974982,0.0011147424,0.03376953,-0.05302484,-0.06353253,0.02318666,-0.013855474,-0.0011759842,-0.07744623,0.05856743,-0.0032429309,0.07067276,-0.027873026,-0.005149688,0.0007190151,0.03567148,0.07202277,0.03759844,0.047059402,-0.04130554,-0.062468562,0.048540976,0.02308159,-0.008310433,0.02101333,0.033790126,-0.021427207,0.02230579,0.0073887305,-0.022818368,0.026933925,-0.036694277,-0.040235873,-0.0009899118,0.024263566,0.035652757,0.02120512,-0.01692211,-0.0936379,0.046539076,-0.020719314,0.010002069,-0.008138239,-0.028794536,0.039204225,-0.063420005,-0.0066142296,0.046020992,0.013083982,0.027834117,-0.030324263,-0.06671684,0.05330238,0.06967211,-0.037584864,-0.05567862,0.042584505,0.08925514,-0.030001583,-0.040149238,-0.0023638068,0.060963653,-0.05805888,0.0037865082,-0.004853952,-0.06366252,-0.027559748,-0.029475445,-0.04649716,-0.017168038,0.03431295,-0.003045894,0.00034872748,-0.08473317,0.015318711,0.03809209,-0.06385982,0.05106326,0.0033678499,1.2926782e-33,0.0014145124,0.009455668,0.0362756,-0.005038118,-0.023673048,0.055616792,-0.029885607,-0.018110665,-0.09711375,0.02071943,-0.055748925,-0.0145637,0.09856732,0.031628676,0.0126913125,-0.011012841,0.024707448,0.04701667,0.012025064,-0.05504846,-0.0048864093,0.103900865,-0.014523527,0.008021934,0.056626618,-0.015412864,-0.09158047,0.002752895,0.13674212,-0.0297928,0.03866433,-0.06447335,-0.06079844,0.039878562,0.05786864,-0.041182294,-0.0921812,-0.056721725,0.0128869265,0.0637342,-0.0021653192,-0.04998893,-0.0029367262,-0.019878384,0.042318847,-0.012638692,-0.029773196,-0.034879316,-0.030925514,-0.050817765,0.021303602,-0.011286713,0.040075008,-0.03294883,0.027214373,-0.05463513,0.03818073,0.011683406,-0.023296513,0.09541076,-0.036822554,0.08876505,0.01744995,-0.0702362,-0.00968565,0.009396061,-0.088084556,-0.06822727,0.0069252327,0.06298957,0.011890071,-0.027424352,0.08375885,0.020883795,-0.014697225,-0.017561045,0.050798025,-0.008191755,-0.058449235,0.11438101,0.038301717,-0.07593275,0.04020341,0.037726253,-0.034444332,0.030596389,0.06806635,-0.09580639,-0.025660917,0.023420308,0.04444421,-0.0680746,-0.03584317,-0.07060272,-0.04446715,-3.9584063e-33,0.033900153,-0.026479466,-0.0044321055,-0.07199923,-0.07737803,0.00056828844,0.06791247,-0.02313584,0.0015379882,-0.04568782,0.111873,-0.0077043097,-0.031134138,-0.07933461,-0.013534823,0.044635866,0.0048375875,0.07964183,0.03487243,-0.0054946286,0.033529457,0.08753793,0.0118898,0.10418351,0.09540914,-0.049658448,-0.03647842,-0.0124841975,0.015960647,0.051726326,-0.098206714,0.004262067,-0.025632218,-0.021378879,-0.02294564,-0.03153357,-0.026273372,-0.022486368,-0.017532427,0.004560167,-0.026535552,0.09131968,0.11053868,0.05761868,0.021606866,0.061727133,-0.03946437,0.042070568,-0.06379763,-0.0018241137,-0.06737153,-0.010219261,-0.08134434,0.067234844,0.066036835,-0.019647788,-0.061910056,0.023441402,0.059002873,-0.07303712,-0.0479156,-0.11762485,-0.014965253,-0.05702511,0.041795596,0.07830848,-0.06947101,0.011956703,-0.039102655,-0.005477451,-0.013936089,-0.0073106675,0.04456779,-0.0041226903,-0.04826632,-0.02683965,-0.051799934,-0.04262962,0.0026715032,-0.07474124,0.0071186717,0.031126143,-0.009052744,-0.016286798,0.06477157,-0.06747227,0.07040975,0.09285612,-0.014300143,0.056790624,0.017144646,0.021505453,0.031922743,0.061429955,0.08016892,-3.0599672e-08,0.09885834,-0.02252746,0.016558599,-0.10435285,0.033410206,0.035497196,0.018591931,0.06753095,0.053650852,0.021702219,-0.014139443,0.029479474,0.0013798056,-0.025755176,0.10836786,0.026695417,-0.06195346,0.017456958,-0.016133377,-0.02311417,-0.07984567,0.040714554,-0.13687538,0.058432005,-0.047111448,0.052997302,0.056086663,-0.03971768,0.02125123,0.0052854596,0.050954487,-0.0134304855,0.031831503,-0.15022938,0.019253304,0.0364919,-0.032492474,0.018355962,-0.09137037,-0.0037515599,-0.07539406,-0.078178026,-0.008182108,0.06858469,0.01328737,-0.033689365,-0.032511897,0.066577755,-0.025001882,-0.050690413,0.017698485,-0.05656694,-0.017621005,-0.100648135,-0.032043237,-0.07779745,-0.022338752,-0.035327706,-0.071229875,-0.007163005,0.019137504,0.0051587294,0.19891562,0.016335232 +3.1.3.33,Does not act on nucleoside monophosphates. Induced in Escherichia coli by T-even phages.,384,0.99999994,-0.046908353,-0.0799402,0.042896304,-0.03966429,-0.053695794,0.016572414,-0.007886367,0.08981411,0.083900064,0.07467974,0.0498189,-0.0030884768,-0.020816924,0.1300675,-0.016498022,-0.06030845,-0.0077322153,0.06870345,0.06560704,-0.08084389,0.10396129,0.055668075,-0.0048944233,-0.017992508,-0.017816212,0.025975222,0.0120284725,-0.04052809,-0.014060922,-0.05662967,-0.12632927,-0.007481561,0.03965821,-0.08103056,0.061710525,0.088997014,-0.042722553,-0.0355711,0.08026739,-0.03250287,0.04949536,-0.026739849,0.0012994059,0.020541396,-0.034383763,0.0077622314,0.02010263,0.016424345,0.008952297,-0.026208982,-0.004557246,-0.014026281,0.027900452,-0.04337102,0.029689426,0.04678244,-0.0030199704,0.015152728,-0.0035584222,-0.0060034688,-0.03863182,-0.03553276,0.05842109,0.047753725,0.11379636,-0.004303087,0.044790033,0.04335045,-0.042712275,-0.012117453,-0.01174996,-0.005934,0.029959232,0.021508057,0.011710756,0.032662105,0.0023346327,-0.046425376,-0.024451315,0.07477769,-0.010017125,-0.07870997,0.05493594,-0.013733841,0.03825916,-0.03654743,-0.046202257,0.07201389,0.012836261,0.105794154,-0.0018968345,-0.014396712,0.07506181,-0.038900938,-0.00023030976,0.011481853,-0.05623375,-0.012182023,-0.08551748,-0.056076895,0.018692564,0.09961488,-0.06455799,0.004546789,0.07638408,0.016470771,-0.0014400216,-0.05452677,-0.009078234,0.033113867,0.033150226,-0.032659117,0.049171798,-0.065126866,-0.037572067,-0.022908809,-0.003208827,-0.026447998,-0.072898306,-0.03692705,-0.012532118,-0.1308636,-0.037383094,0.08106717,-0.031637177,0.030994505,-0.033751477,7.932616e-34,0.08825251,0.016482852,-0.01320359,-0.03881188,0.009138286,-0.017282706,-0.009721191,-0.06549169,-0.055688117,-0.033993844,-0.027303224,-0.10039434,0.06101769,-0.020595016,-0.045972247,0.0069205537,-0.031772517,0.07559472,0.053164195,-0.025012482,-0.0060386644,0.04014168,0.0010145375,0.0068399627,0.04002111,0.014850267,-0.16004239,0.02342898,0.07292403,-0.007856269,0.01210992,-0.024162816,-0.10147593,0.044837028,0.08160811,-0.079742685,-0.099332295,0.002687056,-0.010930123,-0.024698721,-0.030753324,0.015579213,-0.043188397,0.010268705,0.035807885,-0.024124395,-0.03596177,0.005132483,-0.025332108,0.026795259,0.005494798,-0.061190326,0.020405183,-0.066782504,-0.013516483,-0.04292654,0.030601015,-0.029060045,-0.011972267,0.07322991,0.013306502,0.028311618,-0.03097551,-0.016883807,-0.020710146,0.037135962,-0.07049859,-0.11117996,0.03745945,0.09115792,0.023134662,-0.05309227,0.006572893,-0.016872669,-0.03545978,-0.008377049,-0.006353896,0.00539727,-0.037081316,0.051001526,0.12205279,-0.10535016,0.026297102,-0.0038992863,-0.0087489,0.004378919,0.027583135,-0.07195143,0.039267253,-0.011761442,0.12359111,-0.027964855,-0.06503021,0.017263034,-0.031859826,-3.013699e-33,0.053218983,-0.0055720713,-0.034451824,-0.020049155,-0.13156359,0.015325366,-0.031248253,-0.0463882,0.051301125,-0.04588012,0.05888421,-0.02535933,-0.08742954,-0.041825563,-0.06277746,0.026504956,0.09230083,0.08136638,-0.017340545,0.04006244,-0.03283262,0.02098559,0.048810303,0.1085831,0.08280538,0.015143463,-0.060600933,0.023981566,-0.024923038,0.023333248,-0.047838908,0.032990973,-0.07855609,-0.049814753,-0.016800327,0.0010654621,-0.017134601,0.016315822,0.09563025,0.026170725,0.09164142,0.035448812,0.0737152,0.043786727,-0.010115971,0.008388918,0.004051668,-0.019547194,-0.070300475,-0.08051756,-0.014314043,0.009426286,0.04031886,0.00463203,0.018469239,0.03855882,0.032552525,0.049814515,0.0032158014,-0.059909783,-0.017252317,-0.088402055,-0.06216243,-0.043014422,-0.024330666,0.025037946,-0.035694662,-0.005136352,0.07003678,-0.049585167,-0.02515256,0.09485625,0.03745675,-0.055297785,-0.04398083,0.0031950506,-0.07924758,-0.052461915,0.06102588,-0.015568023,-0.059613764,0.10159891,-0.07729889,-0.07268777,0.051442884,-0.06364441,0.0399655,0.06464049,-0.022117358,0.038042527,-0.0215176,-0.017010009,0.060817175,0.06815214,0.056483258,-2.7715789e-08,0.09719884,-0.060724374,-0.015706757,-0.026013952,0.04597965,0.015670998,-0.0046999254,-0.01995808,0.06210483,0.014843704,-0.032529972,0.024018288,0.010876605,0.03937991,0.16687411,0.061688967,-0.0823386,-0.031951208,-0.037962046,-0.039078098,0.00282932,-0.00040156167,-0.097320214,0.067470826,0.009459761,0.043931905,0.04023728,-0.015524453,-0.022999948,-0.041328568,0.03833567,-0.059191696,-0.052908048,-0.058716003,-0.019923266,-0.010753195,0.023241976,-0.037943713,-0.043436415,0.04097668,-0.08742907,0.043851025,-0.0714384,0.06758847,-0.028297968,0.07851306,-0.0033528677,0.068858616,-0.049526192,-0.05349116,0.051787008,-0.008424431,-0.058981266,-0.017744986,-0.027413731,-0.032239616,0.087874025,-0.05141264,-0.011747149,0.036392603,0.052678443,-0.00066632207,0.11262633,-0.08649341 +3.1.3.34,Also catalyses the selective removal of 3'-phosphate groups from DNA and oligodeoxyribonucleotides. Induced in Escherichia coli by T-even phages.,384,1.0,-0.08731746,-0.034339152,-0.016141698,-0.052315786,0.0007847361,-0.004889705,-0.02276313,-0.011371827,0.054043457,0.0598869,0.06073891,0.05838292,-0.06622157,0.038877394,-0.0025119754,-0.026207399,-0.09681463,0.12595914,0.041911006,-0.095617265,0.07372348,0.02847967,0.03992836,-0.01634757,-0.008124998,0.08725313,0.03845197,-0.035227906,5.643913e-06,-0.042256836,-0.045576345,-0.05994997,0.020819321,-0.1125585,0.06762679,0.014277728,-0.020097071,-0.016999342,0.048369706,0.028592603,0.036152743,0.009206561,-0.012530146,0.04939984,-0.030640287,0.0009994984,-0.024887133,0.008203663,-0.022821538,-0.06949412,-0.01470638,0.058695097,-0.056993075,-0.013525002,-0.0024032542,0.0630837,0.025800131,-0.014105622,-0.008716049,-0.020694884,0.028319087,-0.0065926732,0.032532927,0.02270152,0.116252266,-0.012033211,0.057429116,-0.028529184,-0.05241587,-0.022658557,-0.044373643,0.0031491355,0.036281817,-0.02198533,0.043241434,0.054582108,0.0050591715,-0.040551808,-0.03457261,0.09100286,0.006586009,-0.110526204,0.010142298,0.08866844,-0.0015569434,-0.055361602,-0.049629793,0.06830845,0.028579652,0.10959325,-0.02636772,-0.01693602,0.061958622,-0.037125524,-0.020817546,0.002090213,0.0025827452,0.0023357451,0.011547207,-0.047844253,-0.0034633917,0.07019163,-0.044586193,-0.039014414,-0.01881543,0.036360703,-0.03400492,0.04882149,0.008600387,0.034453537,-0.039559845,0.027187418,0.024581086,-0.04800159,-0.116218284,0.025872264,0.05270668,-0.050244223,-0.021164067,0.012431363,0.021382613,-0.09950999,-0.0030653002,0.05748364,-0.02108755,0.036982406,-0.0248175,1.7866581e-33,0.022503132,0.053325918,-0.00039693448,0.012887078,0.0071002613,0.0028828965,-0.06049149,-0.06444779,-0.092327856,0.014815765,-0.020068673,-0.07623568,0.09308767,0.0068762912,-0.037538197,0.0071791685,-0.07687952,0.028957855,0.0042636804,-0.023166463,0.034292307,0.027170524,0.007998657,0.05373425,0.019593555,0.012286054,-0.11359569,0.035393093,0.022415498,0.006496041,0.102492265,-0.07968168,-0.14909098,0.006968565,0.07123004,-0.033486467,-0.039802253,-0.083125226,0.025625328,0.09588164,-0.066117235,-0.011294809,0.014335919,-0.009634238,0.06396524,-0.003165293,0.0049086935,0.0176344,-0.022177206,0.048366923,-0.0014964524,-0.047839124,0.020669654,-0.042749863,-0.017354576,-0.06528682,0.010228389,-0.049055416,0.025060292,0.03286955,-0.027915923,0.04288461,-0.026945094,0.0033393544,0.00019384177,-0.027878221,0.032852918,-0.04469883,0.038600896,0.07218089,-0.012678567,-0.03015288,0.022937631,-0.018938135,-0.026179127,0.011059532,-0.008734323,0.00029063638,-0.027923223,0.0374832,0.060736064,-0.046392955,0.033826936,-0.017281273,0.007988768,-0.03066375,-0.065950856,-0.072547,0.023735275,0.048501723,0.059525736,-0.050107397,-0.10711948,-0.017492132,-0.008644977,-3.7015983e-33,0.10451401,-0.03286911,0.016271435,-0.06999104,-0.13362192,-0.040584944,0.010611209,0.03851421,0.096690886,-0.038968354,0.014472698,-0.020504747,0.048531413,-0.08137551,-0.019818852,-0.029164426,0.04182122,0.026115093,-0.0027364271,0.056766324,0.07278882,0.009429933,0.017185187,0.09898392,0.0644139,0.021542532,-0.09978017,0.03434432,0.0038984043,0.05105333,-0.044179875,-0.021320917,0.028044194,-0.028128052,-0.0068037477,0.06690642,-0.024214426,0.099973574,0.023448162,0.015243187,0.023485731,0.031509876,0.030893017,-0.0043980475,-0.06927269,0.09581002,-0.008341769,0.018551763,-0.0069888644,-0.023152746,-0.005430117,0.032380328,-0.024472648,-0.04837659,0.041793425,0.010650374,0.0086757615,-0.06672541,0.01844081,0.0014509021,0.03566938,-0.057799418,0.034624334,-0.031552114,-0.007987554,0.021836678,-0.0057505784,0.029014299,0.060147487,-0.08820177,-0.0378873,0.054827895,0.069437064,-0.006671778,0.012340766,0.010485418,-0.13438638,-0.023116386,0.036990277,0.0348507,-0.002330376,-0.013895896,0.013077023,-0.073384345,0.036530975,-0.053329024,0.03086293,0.09529436,-0.05476533,-0.0477017,-0.022905987,-0.016044568,0.10281981,0.076084405,0.045899443,-2.9353679e-08,0.07594013,-0.090649284,0.04289968,-0.034008007,-0.016509695,0.035036698,0.009253761,0.101963766,0.08157494,-0.023516439,-0.006894606,0.07334386,-0.011852068,0.010554695,0.14523445,0.02595442,-0.114793494,-0.06385065,-0.03797272,-0.05458134,-0.060914893,0.026570436,-0.098952085,0.005223808,0.05216257,0.06492062,0.015391045,-0.048178226,0.0018167445,-0.017660053,0.038504776,-0.083280735,0.0004830275,-0.014465058,-0.045535613,-0.028813653,-0.046211086,-0.046172976,-0.04192287,0.023466565,-0.054715436,0.06897445,-0.10934086,0.03869556,-0.06991486,0.04185149,-0.05138186,0.102430426,-0.11442823,-0.04571872,0.06686979,-0.07529865,-0.08368341,-0.008689381,-0.08591238,-0.027224,0.08007336,-0.05281532,-0.047509454,-0.01294737,0.0341331,0.0048952415,0.16571827,-0.07671783 +3.1.3.35,"Acts on 5-methyl-dCMP and on TMP, but more slowly than on dTMP.",384,0.9999999,-0.051090464,-0.071768284,-0.010299979,-0.02018112,0.09468603,-0.046442263,-0.024291651,0.012809833,0.028921723,0.04939895,0.06873412,-0.030603258,-0.0815778,0.018897763,0.021902641,0.021086203,0.0040130704,-0.041893724,0.0020742936,0.00024784222,-0.036646836,-0.048588913,-0.06109998,-0.04540503,-0.050198384,0.048454717,-0.049752813,0.04701758,0.0294141,-0.06807464,-0.07339315,0.042119402,-0.03377192,0.029045273,-0.011521204,0.058014136,-0.04710375,0.017687904,-0.009706031,0.013993307,0.07654647,-0.035064485,0.016567148,-0.0044080405,0.021127038,-0.05166439,0.058637988,0.0075027226,-0.067304105,0.006311781,-0.0047303494,0.011986984,-0.036008555,0.044802774,-0.07295753,-0.002424405,-0.05091252,0.051392034,-0.049087197,-0.002802291,-0.06394658,0.046054374,-0.062293824,0.02993529,0.111687355,-0.007937202,0.045087658,-0.048069358,0.0709029,-0.023741787,-0.043629356,0.03661555,-0.013985176,0.027423903,-0.0248452,-0.0053512454,0.044189755,-0.05066143,0.09054334,-0.116766274,-0.054410316,-0.017449738,-0.013981911,-0.062083572,-0.044156875,-0.011218214,-0.031293266,0.041282855,0.037164364,-0.039123435,0.04968809,0.07319262,-0.10501805,0.020799186,-0.042575546,0.030672897,0.068921305,0.06519875,0.02292629,0.002465656,-0.010962285,0.005091729,-0.16623609,0.04101751,0.023813223,-0.033763792,0.11659036,0.049746502,-0.08865401,0.011791463,-0.034971632,0.067771375,0.035559203,0.022779869,0.026297593,-0.015183054,-0.027381262,0.030412678,-0.068064585,-0.06852377,-0.071148574,-0.0031054968,-0.05849882,0.050837815,-0.056790482,0.014195847,0.038816106,-5.117594e-34,0.06896792,-0.029912496,0.024792822,0.02004237,-0.059646085,0.036496583,-0.043224927,0.026941337,-0.0106905745,0.06606947,-0.013788414,-0.04204816,-0.008876226,0.09924274,-0.0362151,-0.024812885,-0.027571265,0.024928523,-0.019635271,-0.059653886,0.02148158,0.16334502,-0.10110268,-0.035369407,0.007885179,0.08501494,0.0009734676,0.039672732,0.01393701,0.020812454,-0.038743686,-0.023552658,-0.050302215,0.017233497,0.049047384,0.09977425,-0.075483285,0.09591607,0.014700673,-0.036577918,0.05618184,0.014696822,-0.07826871,-0.007204491,-0.016880615,-0.0411894,-0.069115974,-0.030013928,-0.027490009,0.021330576,0.06269115,-0.0014947382,-0.011317807,0.035033558,0.027278107,-0.019683043,0.045069497,-0.028899727,-0.010581885,0.11644339,0.026588796,-0.028777506,-0.029569995,-0.05555943,0.019490749,0.017432861,-0.028739326,0.01069302,0.047718666,0.0046330965,-0.00687964,0.07005967,0.08981179,-0.044231463,0.01260786,0.03163853,0.015012369,-0.0684249,-0.015169265,0.0013219406,-0.075510494,-0.040228873,0.050553937,-0.097043365,-0.06502385,-0.04552513,-0.031377614,-0.05892993,-0.07352491,-0.062768415,0.057340384,-0.010036827,0.03256863,-0.009245193,-0.050837595,-2.0738003e-33,-0.04268577,-0.07630156,0.01644258,0.03035736,-0.037094105,0.048605956,-0.042603727,-0.02284187,0.0039374717,0.00057360297,0.07074099,-0.022404596,-0.077658266,-0.042955708,0.06997799,0.060164273,0.013515864,0.041465215,0.0025886206,0.055057213,-0.0012624472,0.098427325,0.001717688,0.107038274,0.009001143,0.07560563,0.011110493,0.02015623,0.026344419,0.046553,-0.03188826,0.011806034,-0.039512128,-0.0062371194,0.052066073,0.08843262,-0.015349638,-0.00571741,-0.07820455,0.0070371195,0.03195425,0.0045185583,0.053698685,0.014962099,-0.03045745,0.13197047,-0.010596539,-0.053546738,-0.036106594,0.092300214,0.059998978,-0.11274828,-0.0064034173,0.025430812,5.037931e-05,0.045845345,-0.015079017,-0.034358952,-0.07259315,0.0116856685,0.04478342,-0.02907233,-0.0641269,-0.11980497,0.0057508633,0.020853931,0.04738014,0.036122438,0.054243203,-0.028503962,0.10345269,0.06192649,0.021326378,-0.04814801,-0.087972976,-0.10496064,0.055841118,-0.03577251,-0.046416428,-0.036840748,-0.05396166,0.07394769,0.033923514,-0.06671792,-0.05090015,0.0007760385,-0.08585452,-0.033021256,0.022029689,0.07693739,0.01178664,0.03396825,0.056339893,0.083174996,0.00656964,-2.2739084e-08,0.080834664,-0.035659272,0.043837987,-0.007925701,-0.021208754,0.10830835,-0.030909132,0.07278717,0.101491265,0.0033091148,0.09377202,0.034041606,0.05749962,-0.012040509,0.04923673,-0.056517605,-0.118356325,-0.07539012,-0.02537275,-0.10971496,-0.10523832,0.013580839,0.004067336,-0.007598526,0.008457288,0.017015288,0.030537138,0.05779694,0.040610157,-0.05346523,-0.016134929,0.044275556,-0.022065528,0.042198144,0.0153587535,0.046555426,0.06538709,-0.015548089,-0.06284092,0.06957403,-0.03712177,-0.0050018043,-0.060474087,0.0071353684,-0.03607307,-0.059395522,-0.032601338,0.005711046,0.034632903,-0.0026196213,-0.007517947,0.05805552,-0.078948334,-0.021285791,-0.06808112,-0.04741375,-0.112602666,0.0005836246,0.0555266,-0.0053138174,-0.027534205,-0.0025109623,0.010023343,-0.02366912 +3.1.3.36,"These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase.",384,1.0,-0.107033804,-0.06724592,-0.0055713477,-0.066304624,0.09383944,-0.027982475,0.039898284,0.0151207475,0.06400158,0.074947424,0.011423037,0.057523254,-0.09201003,0.064388126,-0.009108303,-0.0018400872,-0.05356822,-0.014752629,-0.0018066553,-0.07031085,0.05358671,-0.046526186,-0.07035464,0.038951278,0.007990283,0.037636008,0.0783535,0.01906673,-0.05770086,-0.058856364,-0.094999,-0.036834836,0.037358925,-0.11173993,0.022344628,0.10407052,-0.083518036,-0.060670376,-0.0062218215,-0.0226744,0.1335613,-0.052447643,-0.048672047,-0.043088503,-0.03205788,-0.024013955,-0.07930501,0.036955472,0.07631701,-0.036272574,-0.06320004,0.005722889,-0.040096153,-0.044487353,-0.0620745,-0.025799535,-0.069264986,0.08934497,-0.024998175,0.04247608,0.008516468,0.011742957,0.0199869,0.08001257,0.006322085,0.004013605,0.092756,0.008939324,-0.032789897,0.015079082,-0.063189134,-0.0132203335,0.018600741,-0.0029802152,0.0212098,0.047509164,-0.013747691,-0.040187664,-0.040309783,-0.035962176,0.0027344504,-0.013679249,0.010324831,0.06876332,0.023382287,0.018229755,-0.08417254,-0.014403994,0.009343686,0.014885027,0.053983297,0.003633134,-0.005236218,0.016568802,0.014096844,0.0396264,-0.046328634,0.0101446565,0.03922791,-0.036060147,0.009351254,0.06763848,-0.11788225,-0.046838358,-0.033646826,0.012556407,0.009118259,-0.036678214,0.017062923,0.043221287,-0.03214467,-0.063747965,0.035342906,-0.007068597,-0.017324543,0.052463368,-0.023774888,-0.013764185,0.024772987,0.0011682954,-0.032115653,-0.05541811,0.041768752,0.06352977,-0.10455734,0.039196864,-0.0677087,1.6312434e-33,-0.01506547,0.045522455,0.027626319,-0.009147139,0.008736644,0.025597373,-0.011756865,-0.043597616,-0.089977466,-0.017874183,-0.03254725,-0.09100911,0.08118175,-0.0552516,-0.004649127,0.007895841,-0.012532877,0.08916874,0.05015837,0.03269587,0.0396819,0.051891137,-0.06626071,0.043407768,0.055515405,0.11364142,-0.08403928,0.006593574,0.022594199,-0.0076200156,0.012179961,-0.030147348,-0.0880654,0.019175516,-0.013450266,-0.064378805,-0.028596934,-0.040818974,0.011353855,0.042039257,-0.042727575,-0.020129466,0.0021034575,0.0023513022,0.02006596,-0.05169717,-0.07171596,0.06261569,0.030682595,0.001773674,0.012627894,0.0034816016,0.102572955,-0.059836373,-0.060772948,-0.025938507,-0.05484155,0.013007152,0.060569223,0.07142579,0.030943424,0.081846565,-0.03579292,0.0099468,0.02069034,0.05247906,-0.08203528,-0.03783943,0.018837493,0.0789621,-0.0031010183,0.0029990345,0.017736811,0.020076642,0.06523179,-0.012498132,-0.022730254,0.031263724,-0.043139964,0.07870122,-0.02178974,-0.06664927,0.054939494,0.049648292,-0.031963218,-0.0025780129,0.009739864,-0.05196348,0.07082118,0.051162947,0.1128477,-0.0762937,-0.08431134,0.033754747,-0.06076697,-4.2275053e-33,0.10039866,0.0023429687,0.037033115,-0.12294379,-0.13311473,0.06377941,0.083302625,-0.06269002,0.12252619,0.044964954,0.05955232,-0.014180687,-0.009853551,-0.06537931,-0.061285898,0.047133222,-0.03149713,-0.012517599,-0.0013475408,0.0048447773,0.041468333,0.05477654,0.0040356824,0.1252414,0.0054607755,0.026039284,0.0146255335,-0.021427412,-0.015174704,0.055181447,-0.042350385,0.0037301453,-0.03337283,-0.010067094,-0.024845866,-0.025748251,-0.08226806,0.008151288,-0.04238357,0.018177621,0.005897495,0.09467123,0.07945097,0.005113482,-0.062517084,0.027868645,-0.025099052,0.09312198,-0.044595554,-0.055405114,-0.038147192,0.08165675,-0.03647924,0.039563574,-0.013752125,-0.029457523,0.029089589,0.02571783,-0.02788354,-0.038093034,-0.04833325,-0.07720659,0.053649034,0.025182176,0.06037865,0.05956224,-0.0053943885,0.013293467,-0.0015453912,-0.06158291,-0.009627514,-0.028761128,0.020028457,-0.0043604006,-0.0030156672,0.013902544,-0.053590026,-0.022600893,0.011935238,-0.00897624,-0.010151878,-0.017286941,-0.073495865,-0.0653593,-0.024750875,-0.0010701005,0.020779757,0.09853999,0.053761594,0.043313414,0.0230442,-0.004168275,0.021327175,0.027315605,0.058253024,-4.2414236e-08,0.11908714,-0.074393615,0.06695729,-0.036038246,-0.10758375,-0.056925997,-0.019842297,0.06942558,0.07297065,0.0027942292,-0.032443374,0.05239346,0.052922018,-0.012499965,0.07622627,0.0147651965,-0.025183171,0.018192455,0.0047834227,-0.080797344,-0.06747997,-0.048097212,-0.11046643,0.01250261,0.061613277,-0.03307531,0.049150813,-0.026290346,-0.015651794,-0.0074274177,-0.048526075,-0.0013167423,-0.009311658,0.0148790935,0.04036652,0.06611701,-0.008344269,0.0025218504,-0.10674827,0.046668913,-0.11319957,-0.10141567,-0.070404716,-0.010980729,-0.014027867,-0.0040777368,0.004901394,0.007741991,0.033823334,-0.001606955,-0.047426656,0.012101833,-0.0376802,-0.047285166,-0.023352273,0.0101794675,0.0015452941,-0.024352396,-0.038393803,0.010946167,0.04953409,0.018346384,0.19077602,-0.043561004 +3.1.3.38,"Wide specificity, but 3-phosphoglycerate is the best substrate.",384,1.0,0.06242472,-0.09541727,-0.01860264,-0.06084041,0.010070703,-0.057664014,0.017570881,0.057673678,-0.043676563,0.033080738,0.0038709706,-0.06045143,-0.13790022,0.13746408,0.031222416,-0.03858277,0.032028582,0.011756663,0.054796644,0.057693034,0.18096851,-0.003606125,0.034800682,0.015890395,-0.026112325,-0.018954176,0.041517008,-0.006679428,0.016459532,-0.10062385,-0.052735645,0.012730783,0.017551925,-0.08134345,0.0051413975,0.046906445,-0.08409603,-0.027452094,-0.016886063,-0.0051729693,0.048333183,-0.0022099898,0.04593111,0.008652437,-0.032053217,-0.04220484,-0.004325227,-0.029856112,0.059287652,-0.025422683,-0.02860547,-0.091086574,-0.07289085,0.07757195,-0.036180872,0.042781625,-0.092008814,0.07463316,0.014579362,-0.018916458,0.017745191,0.04156522,0.014079228,0.011753146,0.12867294,0.03544871,-0.014180105,-0.04283177,-0.02699639,0.07697057,-0.04888321,-0.0050220266,-0.0019658492,0.02425904,0.07256202,0.16952638,0.056260914,-0.03071833,-0.018832788,0.030387811,0.01687504,0.079795375,-0.008208412,0.06535641,0.048951674,0.020499546,-0.07239452,-0.05453023,-0.06717458,-0.013582772,0.00033631624,0.074933246,0.039031696,-0.0058305995,-0.020585306,0.03246588,-0.0066094105,-0.011018522,0.04670868,-0.018229553,0.020416567,0.100935236,0.011362539,-0.0066926577,-0.03321979,0.0017710287,-0.043009363,0.0012494983,-0.009879067,-0.004370507,-0.0029251196,0.030009564,0.02782682,-0.050315894,-0.023194939,0.031958077,-0.00034775856,-0.0511573,0.020467598,0.01818721,-0.059164952,-0.045638967,0.010344977,-0.0043836753,-0.042351622,0.0084778555,-0.050843924,5.0562365e-34,0.014610677,0.07367223,0.0057609095,-0.0052659935,-0.026067536,-0.015068316,-0.06367851,-0.09414706,-0.038434155,-0.009288146,-0.047287013,-0.032828327,0.004018721,0.09432289,0.06777885,-0.038821455,-0.07333614,0.060783446,0.02543042,0.008315569,-0.024872735,0.002319636,-0.059279464,-0.062820025,0.08651386,-0.029247787,-0.020267552,-0.02202798,-0.047142494,-0.011305299,0.04155821,-0.014931769,-0.024651762,0.012666281,-0.0241924,-0.008160285,-0.12868272,-0.067833394,-0.00656318,0.016631419,0.011585043,0.02560232,0.08986197,0.046753716,0.117104314,-0.020687664,-0.0983641,0.05427451,-0.033882167,-0.007581389,0.0455558,0.014300969,0.08039958,0.005908078,-0.014038579,0.008134871,-0.0062391884,-0.061141502,0.044854406,0.057412535,-0.036640845,0.07638806,-0.03944277,0.068645366,-0.05594008,0.07028244,-0.10750678,-0.051129024,-0.07283609,0.0070738476,-0.010536755,-0.038555387,0.09547619,-0.0028442317,-0.050798304,-0.045170717,0.030511765,0.01410543,-0.005539019,-0.0065746116,0.044491984,-0.024313295,-0.07016721,0.014340623,-0.14676821,0.023622917,0.048123658,-0.07326472,0.011404605,0.06801514,-0.0100685,-0.052906387,0.005408173,-0.022250654,-0.09898533,-7.649016e-34,0.10196825,-0.092870966,0.054897975,0.004498509,-0.011078314,0.018457957,0.051238477,-0.028931892,0.042455252,-0.011615401,0.041109193,0.0490047,0.017506037,-0.08947365,-0.009020533,0.09189106,0.015121658,-0.021898353,0.098732814,0.007142497,0.04939906,0.1068668,-0.021106746,0.09322858,0.06780953,-0.020177836,-0.040768534,0.00298651,-0.033007927,0.051358137,-0.08849263,-0.011347062,0.011820317,-0.081731685,-0.050305784,0.012633612,-0.016489895,-0.05825194,0.0025725698,0.04530037,-0.028120255,0.026231421,0.026799835,0.029698918,-0.034611687,0.09644453,-0.016065154,-0.01773401,0.030416362,0.059909057,-0.017161768,-0.019411916,-0.035998218,0.005084192,0.044008795,0.057585754,0.0071795234,-0.033972144,-0.03804153,-0.037837643,-0.021363404,-0.019325238,0.032441027,-0.03598023,0.06839142,0.070813015,-0.02673698,0.012274373,-0.065120004,0.04403687,0.017442858,0.005156871,0.040300645,0.04515356,-0.01616559,-0.01770762,-0.067460634,0.0074070096,-0.01809122,0.056637593,0.008173477,0.055100515,-0.0017687118,-0.006905152,0.15121251,-0.017454304,-0.033113394,0.023407044,-0.030039812,0.029565847,-0.00039400026,-0.08623508,-0.017149083,-0.03742969,0.09114861,-2.3419311e-08,0.11087154,-0.026076876,0.009762273,-0.074485965,-0.0919315,-0.010273953,0.062056128,-0.013093344,0.0060700765,-0.03849747,-0.03190585,-0.0030909241,0.026404101,0.025968378,0.10538569,0.00019857055,-0.083662234,-0.0076838247,-0.09549563,-0.028874228,-0.08917832,0.018974133,-0.027329989,0.01342233,0.036450535,0.027634444,0.061294604,-0.006726152,-0.040972866,0.04515207,0.03692036,0.012289796,-0.007848736,0.005459299,0.013451878,0.054124013,-0.0427182,-0.013869056,-0.11054935,0.038847357,-0.080035746,-0.060876876,0.0065456773,0.027946314,0.014157688,-0.036689505,-0.030310884,0.033625055,-0.019235091,0.054021485,0.024564274,-0.04008777,-0.012866166,-0.05634207,-0.03805212,-0.05892799,-0.010145431,-0.016504478,-0.018309169,-0.0026667365,0.113852575,0.013081055,0.16172606,-0.009011518 +3.1.3.39,"Also acts on dihydrostreptomycin 3'alpha,6-bisphosphate and streptidine 6-phosphate.",384,1.0,-0.03973024,-0.08295133,-0.07057026,-0.054465365,0.017383872,0.0018759541,0.04006108,0.048333775,0.11279048,0.03271298,0.016080998,0.067699604,-1.22809215e-05,0.094282724,-0.014085487,-0.017387742,-0.075583085,0.053887405,0.07108145,-0.011279227,0.073816024,0.044664007,0.02686788,-0.0056569143,0.0591993,-4.4802677e-05,0.024059027,0.07888332,-0.01706185,-0.05008682,-0.022245653,0.026182026,0.029481342,-0.025946196,0.07103591,0.14409412,-0.09408205,-0.0348151,0.06660974,0.040857933,0.025868762,-0.027147273,0.02670799,0.013286653,-0.009420155,0.034188118,-0.027743557,0.07932437,0.07534213,0.017638428,-0.038562138,-0.0283174,0.002307334,0.077624604,0.065835804,0.03090701,-0.06765714,0.06953875,-0.0015666499,0.020715842,-0.0046770745,-0.05219604,0.019066649,0.009462078,0.0027157383,-0.002829394,-0.013866945,-0.055340476,0.010302216,-0.020655641,-0.04147775,0.021904688,0.07303528,-0.01667702,0.0061908746,0.0272058,-0.07392551,-0.033220384,-0.06542041,-0.057164863,0.03194976,-0.016876664,0.019391324,0.076321006,0.06300832,-0.029669987,0.0190518,-0.023496844,-0.025452478,0.055378985,0.049716152,0.007323378,-0.02703298,-0.079618074,-0.08678241,0.009491972,-0.10031581,0.002286374,-0.0027998122,0.0004581172,-0.010425317,0.042782385,-0.06251837,-0.012356348,0.033091802,0.033781897,-0.048776258,0.012936905,-0.068953894,-0.0072112135,-0.053663373,-0.017615922,0.021516567,0.025785465,-0.016436264,0.044799004,0.08067488,-0.037196536,-0.049791012,-0.06240462,0.00578419,-0.042390518,-0.012307412,0.017647862,-0.05830278,0.05540351,-0.05136613,3.238555e-33,0.021809617,0.08889188,0.017630314,0.025104979,0.042980883,0.034549944,-0.070152804,-0.066000916,-0.044567198,-0.05795252,-0.005453442,-0.06317792,0.07686146,0.0034770924,-0.0016717674,-0.03727144,-0.040209334,0.1030357,0.039260324,-0.050465863,0.09107629,0.09049576,-0.03718047,0.0037231317,0.024582185,0.043436386,-0.07037091,0.071490176,0.080350384,-0.071192026,0.032768663,-0.015938435,-0.02951964,-0.01790733,0.019956153,-0.043878995,-0.07119911,-0.073340796,0.033000723,0.032284882,0.021610877,-0.0326101,-0.039001547,0.02653186,0.039355338,-0.07090004,-0.0060651717,0.057540584,0.07701505,0.05327827,0.08411016,-0.039556712,0.10024853,-0.08508308,-0.076666534,-0.016017579,-0.035110433,-0.049161017,0.018043408,0.04089906,-0.012097184,-0.02147535,-0.005993716,-0.036680914,0.023655964,-0.025313133,-0.07317631,-0.05507096,-0.010143376,0.08009583,-0.041801695,-0.043341424,0.07557064,0.017315207,-0.01155433,0.057163727,-0.08398347,0.01815803,-0.015347212,0.004727804,0.0038975363,-0.041005313,0.045898512,-0.012981935,-0.07197267,0.026494578,-0.017334891,-0.15012482,0.00861306,0.024114592,0.049325902,-0.09440645,-0.13594201,-0.00039458735,0.022246992,-4.266521e-33,0.09453017,-0.026153827,0.09696928,-0.018022912,-0.050756108,0.060465515,0.012155007,0.0038633526,0.059655096,-0.076280646,0.03964754,-0.044738144,-0.036591485,-0.064839445,-0.023982165,-0.012291112,0.023034845,0.08990107,-0.010013631,0.039012454,0.034864265,0.09094119,0.03974019,0.08596119,0.073019005,0.020894933,0.05471204,-0.011891,0.027963696,0.05832119,-0.006422413,-0.02407281,-0.05356018,-0.06281624,-0.03230587,0.036230735,-0.07593889,-0.01580586,-0.030387152,-0.04443862,0.072208196,-0.03489178,0.065195635,0.042183045,0.011179199,0.022307862,0.034222323,0.104199685,-0.028305432,0.013138506,-0.0051709777,-0.04984803,-0.040221363,0.04735553,0.06871738,0.0045041796,-0.0038430595,-0.06443734,-0.01771957,-0.01227116,-0.018240156,-0.020697095,0.009201852,-0.02860452,0.050227758,0.032622576,-0.013992444,0.041070502,0.12642992,-0.011711471,0.016246982,-0.003223491,-0.0022943586,-0.009177363,-0.053735457,0.023351979,-0.07670605,-0.013503189,0.024684355,0.057137202,-0.060750134,0.025589436,-0.051445495,0.012283519,0.011927115,-0.009117843,0.054263413,0.045413543,-0.01943415,0.027948493,-0.021127874,0.010332066,-0.00074894354,0.016137948,0.0037372091,-2.881603e-08,0.096213624,-0.01639268,0.07317426,-0.084564775,0.008078822,-0.094102524,0.05654124,0.03304209,-0.040060073,-0.0076286364,-0.016760997,0.02367376,0.082161464,-0.08656049,0.035108406,-0.0133985495,-0.07047816,0.016651312,-0.05735791,-0.07460837,-0.0830832,-0.059901197,-0.05163237,0.0913782,0.07028459,-0.018948259,0.0042533376,0.010758443,0.0012956399,0.0068061827,0.08492354,-0.084217176,-0.045671824,-0.09412051,0.043196827,0.03699712,-0.084267415,-0.029618358,-0.012709112,0.0005471889,-0.012883399,-0.03810379,-0.04088327,0.062496245,-0.14261551,0.043021925,-0.07491171,0.009833353,-0.081161946,0.0048525357,0.06992067,0.002484384,-0.0421846,-0.034162138,-0.1220881,-0.0017309668,0.031435587,-0.05495346,0.02820655,-0.049804352,-0.020325864,-0.026011223,0.17292114,-0.023035597 +3.1.3.41,"A number of other substances, including phenyl phosphate, 4-nitrophenyl sulfate, acetyl phosphate and glycerol phosphate, are not substrates.",384,0.99999994,0.026341753,-0.13483316,0.011831885,-0.082072005,0.0228687,0.004618319,0.019083975,-0.024165858,-0.009876065,-0.02792482,0.060245764,-0.046955653,-0.035349216,0.09778926,-0.045960613,-0.059263963,0.026064236,-0.012311179,0.034036797,-1.17047575e-05,0.09144498,0.019835599,-0.011734822,-0.060161192,0.016189614,0.06454627,-0.016621178,-0.03459305,0.064005695,-0.064955056,-0.039743077,0.033460688,-0.011817164,-0.05312608,0.052861433,0.055166155,-0.06921804,-0.001842776,-0.007765633,0.03316872,0.059493616,-0.097602256,-0.022418465,0.011875755,0.04400854,-0.042345703,0.013459425,-0.081676364,-0.023905385,-0.059431557,-0.055267356,-0.015940573,-0.031746577,0.012591451,-0.02594694,-0.0452055,-0.031940512,0.049092263,-0.010710676,0.021555556,0.033221096,0.014363349,-0.010318175,-0.035145395,-0.0036747088,0.02337891,0.009298461,-0.021672862,-0.024597125,0.06882414,-0.01687888,-0.019379037,0.037822798,0.028289529,0.031956427,0.061931934,-0.023098258,-0.026821686,0.03333164,-0.043589216,0.009519466,0.02873104,0.0089078145,0.07600133,0.033658337,-0.027854092,-0.06368213,-0.028531572,-0.0745237,0.008758381,-0.010298323,0.04169157,0.033583492,-0.024925757,0.016741699,0.0045343055,-0.031192759,-0.012343308,0.020587934,0.02616154,-0.02257912,0.0638191,-0.03758084,-0.032204304,-0.07788313,0.042976193,-0.044650096,0.007049646,0.020757657,0.020067872,-0.046660647,0.057689425,-0.016952842,-0.04039296,-0.02355382,-0.028445464,0.02279585,-0.051063187,-0.06593787,0.024061171,-0.059320953,-0.015033323,0.10711544,0.060901884,-0.04470451,0.031474177,0.04838644,3.136662e-33,0.10547211,0.033594683,0.044729847,-0.070187405,-0.039266117,0.016880719,-0.053251274,0.019797577,0.020213773,-0.07001588,0.031805582,-0.0054399697,-0.03691737,0.03469663,0.10306119,0.055357404,0.02532171,0.04067644,0.16975395,-0.011653565,-0.033323087,0.016889324,-0.09790373,-0.009012248,0.0082650585,0.008136568,-0.08448821,-0.017151162,-0.053305343,-0.024100902,0.05287197,-0.04670697,0.060346585,0.0015536199,-0.0023593255,-0.03944213,-0.08005999,-0.015329636,0.011396813,-0.06842315,0.0002525291,0.015327648,0.08370383,-0.010647137,-0.00042925085,-0.015935088,-0.014279866,-0.0065107453,-0.021806655,0.05842011,0.015716234,-0.0022767815,0.027933087,-0.047667246,-0.023907427,0.044965066,-0.041701015,0.016419142,0.0014120612,0.023078553,0.01767741,0.080846265,-0.057567455,-0.016045157,0.022230033,0.051668342,-0.1045616,-0.03899122,-0.021181814,0.041712098,0.008405967,-0.004377115,0.05787385,0.036222216,0.055564206,-0.06438803,-0.0043437765,-0.011835377,-0.033862025,0.020907393,0.01138694,-0.030205105,-0.08765985,-0.08186685,-0.11449226,0.02869653,0.020512301,-0.050502907,0.06324534,0.025311409,-0.021462904,-0.09088818,-0.09314877,-0.03227258,-0.058931984,-5.076133e-33,0.047400028,-0.004139853,0.03284847,-0.021728689,-0.052397884,0.021187281,0.110357165,-0.049766157,0.04574218,0.03899924,0.055098586,0.023087222,0.031507418,-0.047403894,-0.08387522,0.090376705,-0.032499615,0.08052774,0.055207536,-0.02072023,-0.008188374,0.13166402,0.046382852,0.10089393,0.04497448,0.034069315,-0.01103968,0.016548973,0.015673315,0.08081414,0.05359649,0.025393661,0.011769615,-0.12279589,-0.03424088,0.0033381877,-0.0063701835,-0.040167753,-0.08952661,-0.07457187,0.07129314,0.048761576,0.058993496,0.03263028,-0.038976394,0.045153778,-0.003974706,0.012672387,0.021989273,-0.0505612,-0.0054277102,0.061274823,-0.07889835,-0.029511834,0.057729516,0.12662019,-0.01865275,0.017244333,0.0012770435,-0.060216438,-0.017430505,-0.03846693,-0.03778674,-0.0892868,0.081827395,0.07914473,-0.0060084867,0.0905223,0.03630818,-0.027979467,0.029940447,0.024763308,0.08974074,-0.015672417,-0.05760263,0.032780625,-0.06622872,0.0012854558,-0.057718348,-0.042142406,0.09316642,0.03948984,-0.061438426,-0.05087113,0.014649301,-0.018801965,0.016041713,0.01259967,-0.017987948,0.056554243,-0.010432627,0.009806976,-0.058830045,0.048877347,-0.015937937,-3.6650487e-08,0.12885842,-0.03343333,0.08237894,-0.06832205,-0.124714136,-0.06103168,0.12440389,0.00025730324,0.018988572,0.0056090388,-0.062269423,0.043215815,-0.046456542,-0.0030027858,0.092690006,0.014940242,-0.092799485,-0.045462456,-0.04838679,-0.069290124,-0.061504513,0.017738858,-0.09982895,0.09643048,-0.031944145,-0.027692648,0.09461595,-0.0324313,0.009824481,-0.035343513,0.08275847,0.006840936,-0.03474372,-0.047329657,0.051670063,-0.0019142115,-0.010163296,-0.03648191,-0.06355777,0.07258998,-0.106048815,-0.06460257,-0.03524846,0.06939547,0.053098008,0.03653541,-0.07927471,0.047007393,0.0018420351,-0.007065888,-0.0058758794,-0.0051280377,-0.04149658,-0.10029119,-0.05212945,-0.025131103,0.07651893,-0.021046827,-0.0054742983,-0.025462313,0.03785293,-0.013504302,0.16174951,0.0013858113 +3.1.3.42,The product is EC 2.4.1.11 glycogen(starch) synthase.,384,1.0,-0.044513468,-0.02722451,-0.06789843,-0.010733917,0.05380742,0.030739661,-0.0027917533,0.04985519,-0.024194404,-0.08015145,0.05612944,-0.08443723,-0.0638667,-0.045492698,-0.11776463,-0.016357046,0.04798183,-0.018674593,-0.0015377708,-0.03737268,0.029784689,0.0602528,0.026682062,0.04403227,0.035967134,0.00908984,0.015438903,-0.06675302,0.027991949,-0.0878496,0.03323837,-0.0018794785,0.04991976,-0.008937923,0.032342393,0.019060683,-0.035306208,-0.1206291,0.014957446,0.036664817,0.062013272,-0.03896651,0.007929681,-0.084296644,0.023687426,0.00473894,-0.013021763,-0.04263597,-0.008992706,0.008400049,0.0053895297,-0.092974156,-0.07539112,0.014362199,0.069409445,-0.0034109605,-0.06966602,-0.0048784693,-0.042148452,0.0863943,0.056638207,0.06426661,0.0010993216,-0.029077059,-0.0068850387,-0.011875398,0.06990243,-0.07588059,-0.0004759544,-0.0368265,-0.08381528,-0.07304276,0.032238565,0.016307782,0.018275063,0.058312792,0.034136444,-0.089073196,0.1314318,-0.015459871,0.027954662,-0.013557672,-0.03579849,-0.015161461,-0.026410742,-0.0041085337,0.063857734,0.008796333,0.04425811,-0.0052728993,0.02865357,-0.061317086,-0.014783727,0.031188037,-0.02535848,0.052154437,0.013565053,0.017353792,0.104632944,-0.013145425,-0.060555477,0.049826812,0.004705179,-0.06679408,-0.061745368,0.0027340609,0.048444945,0.065141924,0.048181668,0.02444774,-0.020161752,-0.022225896,-0.033804588,-0.004080488,-0.05936783,0.058617093,0.023071593,-0.039732303,0.00509618,0.024944585,0.08828629,0.0041805776,0.06904991,0.07039351,-0.06883386,0.022201737,-0.047686815,-1.5684065e-33,0.06813286,0.08991314,0.09150853,0.0031744975,-0.0075728926,0.030135894,-0.12962683,0.023011312,-0.030743819,-0.08781203,-0.042199504,-0.030031737,-0.0021630381,0.108111486,0.011518364,-0.07209091,-0.0038407594,0.005314876,0.041116618,-0.05063994,-0.0016642187,0.037586223,-0.034324978,-0.006738941,0.0097685745,-4.9633694e-05,-0.032144155,0.0043455884,0.097328976,0.015241971,-0.009087767,-0.018440813,-0.03127276,0.0062455614,-0.04075407,-0.0062196814,-0.025725799,-0.050121922,0.060535267,0.030063787,0.039535217,0.027561039,0.0038744889,-0.07307546,0.034917183,-0.022013346,-0.07699062,0.07302079,0.07587627,-0.0032805062,-0.008229884,-0.017192012,0.04726914,-0.00865156,2.1677373e-05,0.034525,-0.038716346,-0.0100345,0.047590673,0.100662544,-0.035079848,0.1928158,0.00067907386,0.041593183,-0.027446363,0.005934256,-0.07548692,-0.0313527,-0.08157213,0.0019904147,-0.028188786,-0.031475324,0.12862323,0.024560425,0.017277561,-0.09157877,-0.014065104,0.04016805,-0.037777282,0.011867202,-0.07850107,0.05565634,-0.016566956,0.02194103,-0.04294381,-0.019653836,-0.06482783,0.026664244,0.008818837,0.07516332,0.013717616,-0.0038404553,-0.03519726,-0.011565116,-0.10156098,7.4505266e-35,0.06894919,-0.08523521,-0.003468236,-0.00049787434,0.044155873,-0.0053271255,0.007611935,-0.05373106,0.026271552,0.036390938,0.067709096,-0.03270009,0.056707833,-0.120676085,0.0063859667,0.014241771,-0.044753145,0.06240651,-0.04128358,0.011425522,0.05780471,0.014464299,0.017982991,0.019019298,0.044941384,-0.034038275,0.06385888,0.097418435,-0.0041114846,0.015349291,-0.042359035,-0.041842695,-0.08127976,-0.028709024,-0.0705922,0.025204683,0.011946678,-0.028987521,-0.04726278,-0.06760988,-0.014352574,0.05958921,-0.029593324,0.08416964,0.05525273,0.080527656,0.01088485,0.0043296395,0.014203896,-0.016484126,0.010661435,-0.015649885,-0.034558885,-0.0073866113,-0.0160482,0.060546216,0.004928823,0.043655433,-0.013059604,0.001406263,0.0067307986,-0.024400214,0.049479194,-0.0757135,0.07070861,0.009834539,-0.026993945,0.07351376,0.06852527,0.02449889,0.16202508,0.011013454,-0.03845471,0.038069665,-0.024783216,-0.005733087,-0.06064551,-0.03401754,0.03000307,-0.10465899,0.043666877,-0.042723525,0.032766405,0.000889487,-0.011646874,-0.0328813,0.0455322,0.14548163,-0.0012506803,0.04353953,-0.08821209,-0.0057318886,-0.105667636,0.05294841,0.044825207,-2.5211863e-08,0.051547088,-0.09308541,0.05440643,-0.051840883,0.00916684,0.045731768,0.05023832,-0.002516794,0.053726066,-0.03133563,-0.053498197,0.060719334,0.018592471,-0.056266345,-0.003874144,-0.016029106,-0.057703212,0.095993996,-0.045976542,0.016660186,-0.06950937,0.06290274,-0.035937883,-0.049163204,-0.095681004,-0.08163678,0.07270234,0.08312175,-0.05788179,-0.08220442,0.017517477,0.05306528,0.012434365,-0.06458087,-0.03732281,0.0232581,0.021239305,0.018709095,-0.04083091,0.09456342,-0.021217095,-0.038563684,-0.00771178,0.0010101686,-0.027435796,-0.012826961,-2.2368296e-05,-0.039718423,0.01998226,-0.033574805,0.03954172,0.032147758,-0.04526445,-0.0656315,-0.08849656,0.0299989,-0.07496375,-0.056756712,0.010487295,-0.03678493,0.0037035164,-0.010146964,0.14399818,0.07825927 +3.1.3.43,"A mitochondrial enzyme associated with EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring), in the pyruvate dehydrogenase complex.",384,1.0,-0.09169142,0.054879364,-0.0729126,-0.010213441,0.08063107,0.024356574,-0.09459143,-0.026062842,0.038125265,-0.04296063,0.08845143,-0.06870418,-0.04395116,-0.053121574,-0.0013062911,-0.015460212,-0.08487806,-0.038423296,0.020680899,-0.068139315,0.054215647,0.017266197,0.02292175,-0.0498185,0.031931955,-0.017453153,0.05543916,0.059199724,-0.022724992,-0.07213302,-0.022182519,-0.070352875,-0.0070911176,0.015437272,0.016310673,0.16879834,-0.050348174,-0.07311323,0.00082104,-0.0036613606,0.101439655,0.028495885,-0.041815974,-0.0035181032,-0.054948125,-0.02396395,0.053916086,0.027352525,-0.02037826,-0.021698523,0.0072581354,0.014131971,-0.033113062,0.011624025,0.023347521,0.07460256,-0.00742611,-0.04700174,-0.07111381,0.027464801,0.04333594,0.020533012,-0.029826125,-0.007849616,-0.06837989,-0.05763673,0.13298222,-0.087779015,0.00212248,-0.08430436,-0.06745331,-0.08949606,0.0022283245,0.07947069,-0.025427768,0.012805002,-0.08003071,-0.067349434,0.042759594,-0.0056671626,-0.010504502,-0.034207884,-0.02235779,-0.02225965,0.024594424,0.00848045,0.034893483,-0.051883407,-0.03355816,0.036634307,0.019488512,-0.08959566,-0.028255232,0.010875554,-0.02752276,0.06716467,0.086707324,0.09962698,-0.0029948459,-0.08357615,0.024003228,0.14295901,-0.011998845,-0.03698412,-0.034597185,-0.0043312954,0.032558974,0.07365975,-0.022157282,-0.0016206049,0.0063908105,-0.021790016,0.04663871,0.018746927,0.0026126485,0.12900624,-0.019038351,-0.06590488,-0.010107075,0.052177478,0.084119044,0.020551687,0.050379746,0.08992782,-0.0116236815,0.03983002,-0.08741447,1.11895785e-33,0.0010825014,0.024488145,0.015222245,0.022844795,-0.015434428,-0.030275038,-0.13523297,0.05756688,-0.011187853,-0.013474194,-0.061015625,-0.01511565,0.05256106,-0.011209948,-0.0773167,-0.020035645,-0.058399335,-0.01592237,0.09835827,-0.053293746,0.0019901926,0.052630354,0.020771092,-0.0019318705,0.00043630227,0.05600569,0.00868114,0.0019997994,0.11211033,0.005106974,0.03355601,-0.12833612,-0.08182378,-0.019658633,-0.074867636,0.017145846,-0.027361967,-0.05618851,0.0012453516,0.04223951,-0.03761672,-0.023469912,0.038642596,-0.059787393,-0.039966956,-0.0789689,0.013828751,0.024917152,0.02226753,0.030654615,0.020752013,-0.09220737,0.10565877,-0.056078102,-0.039289266,0.044047117,-0.016167486,0.033912443,0.017877407,0.08740462,0.081624545,0.05654001,0.0033335797,0.03868854,0.09902267,0.014765776,-0.05407243,-0.07987523,-0.043231435,0.04495828,-0.065346405,-0.013528918,0.13180612,-0.022762861,0.03809972,0.016043087,-0.08100313,0.04216404,-0.03735311,-0.00043763968,-0.05728142,-0.003983475,0.0497394,-0.0021348048,-0.00097164774,-0.02112476,-0.007597285,0.027651602,0.021555692,0.041515056,0.032930028,0.007556124,-0.010300827,-0.014364914,0.020059753,-2.938484e-33,0.060822807,-0.10094065,0.029594187,-0.091169775,-0.03969225,0.12271924,0.048536483,-0.017610133,-0.0016697776,0.022039615,0.075948276,-0.019140258,-0.0006538291,-0.09119921,0.102581464,-0.043206945,-0.04779128,0.038545728,-0.026090806,0.040140696,0.027537009,0.07060823,0.030934032,0.0554558,0.033034574,-0.009864481,0.031189319,0.007635534,0.0057223,-0.019338313,-0.015302581,-0.00045219806,-0.040581085,0.014738815,-0.040023103,0.025439769,-0.03738297,0.009712978,0.011178375,0.06260902,0.028776761,0.0639201,-0.009887309,-0.013997667,0.055265594,0.01731644,-0.08360386,-0.022445306,-0.006368816,-0.05475213,0.02045015,0.06377601,-0.058501292,-0.055425473,0.056309424,0.068843246,-0.0042636488,0.02285119,0.0835026,-0.055341158,-0.09151472,-0.05199439,0.034063186,-0.002407855,0.020521995,0.010545406,-0.023138735,-0.03206771,-0.0011210999,0.06558206,0.06852233,0.017358871,-0.040401634,0.018578855,-0.00297328,-0.037927955,-0.012935474,0.009712916,-0.005667003,-0.08630365,0.019225596,-0.029568024,-0.015906947,-0.075398736,-0.020290172,-0.07284815,0.015141014,0.09718337,0.023109289,-0.023859331,-0.0075743953,-0.05328135,-0.099603586,0.018754542,0.026985602,-2.82573e-08,0.020075241,0.02264643,0.08762909,0.020458745,0.02821224,0.036121953,0.05997516,0.019654911,0.026378619,-0.0012888194,0.03842876,0.065109365,0.07060534,-0.011943782,-0.0023541523,0.036432356,-0.04412746,0.0538587,0.03769357,-0.005018455,-0.012653105,-0.027253559,-0.118520334,0.0550161,0.050139304,-0.043189675,0.025504889,0.034992546,0.012814551,-0.10329024,-0.0019501096,0.0108167045,0.02391988,-0.062134184,-0.02212139,0.015522305,-0.0004764928,0.016777785,-0.019434754,0.06750775,-0.029362714,-0.08151899,-0.065098174,0.007269117,0.03888537,0.08519514,0.028489094,-0.013700565,-0.02102479,0.0166192,0.025563668,-0.0029258288,0.016525948,-0.06580667,-0.122421935,0.0040735216,-0.048109014,-0.108082026,-0.0063249734,-0.060784366,0.10965396,0.047043867,0.08811351,0.0030515993 +3.1.3.44,"Simultaneously dephosphorylates and activates EC 6.4.1.2 acetyl-CoA carboxylase. Acts similarly on EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase), EC 2.4.1.1 (phosphorylase), EC 2.4.1.11 [glycogen(starch) synthase], and dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate. Not identical to EC 3.1.3.17 ([phosphorylase] phosphatase ) or EC 3.1.3.43 {[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase}.",384,1.0,-0.058033306,-0.040806636,-0.086904764,-0.077448085,0.065644875,0.06910776,-0.027557101,-0.052970856,0.033026233,0.003119249,0.0002799359,-0.008645991,-0.051021278,0.005049096,-0.033752605,-0.018207794,-0.042572174,-0.03837443,-0.012429268,-0.022334479,0.07317008,0.0088099465,-0.103785306,0.019993898,0.074936785,-0.06995163,0.048874732,-0.034964386,-0.0932098,-0.086244926,-0.012673698,-0.076927245,0.021446057,0.03158046,0.03522468,0.101167336,-0.032736827,-0.111652486,-0.02714236,0.02810294,0.047101285,-0.03139562,-0.023594059,-0.039444014,-0.06896466,-0.00055632193,-0.0116773425,0.024390189,0.0024676376,-0.03406847,0.01209835,-0.0050122873,-0.00871783,0.03317719,0.009336125,0.03376519,-0.05103233,0.044603292,-0.08444743,0.037165824,-0.06230341,0.009591562,0.0702869,0.0015116867,0.011630268,-0.017271407,0.08196141,-0.0771763,-0.03894969,-0.024327137,-0.09781714,-0.060038712,0.06400962,0.008333247,0.036328897,-0.03269144,-0.01216138,-0.012416403,0.008278124,-0.044531085,0.016541462,-0.017632531,-0.030373834,0.01663956,-0.029246598,-0.04442969,-0.01437859,-0.0016321567,-0.024908153,-0.011384596,0.03436314,-0.09580688,0.03390562,0.01797924,0.017096138,0.078204386,0.019451464,-0.015139449,0.047428157,-0.09844964,-0.026671195,0.11461456,-0.041520923,-0.023205599,0.0034278024,0.06173998,0.026479732,0.09686627,0.0070695253,0.035706583,0.040182333,-0.0020695338,0.05030784,0.04089581,-0.0497076,0.09052132,-0.06645578,-0.08228225,-0.05551482,0.004780001,0.07840409,-0.02986502,0.091501616,0.062243458,-0.05255818,0.097352855,-0.084951244,4.791838e-33,0.047615077,0.032971505,0.06280968,-0.0011128356,0.029825766,0.0033282954,-0.10721796,0.06396608,0.017640287,-0.104250394,0.018305056,0.007871602,0.10571749,-0.00073129125,0.0025505056,-0.0025103888,-0.063756004,0.032699265,0.06545023,0.0034660995,0.045722425,0.042404834,-0.050908435,0.044760223,0.0044567357,0.046311628,-0.07395137,0.039183255,0.057473626,0.017159203,-0.00069108576,-0.040477294,-0.028739616,0.028838426,0.007925095,-0.029306725,-0.07321996,-0.04549181,0.038761295,0.036415383,0.06990839,-0.042531,-0.023749063,-0.07594816,-0.005363491,-0.056516316,-0.025848497,0.06390897,0.03573778,0.06272532,-0.00412836,-0.03434181,0.12781768,-0.0345094,-0.0065746186,0.028292254,-0.08128575,-0.06150405,0.055730943,0.07671934,0.013311065,0.10979408,-0.02258811,0.0057236156,0.01900232,0.033523735,-0.114073984,-0.06366549,-0.032084584,0.09277449,-0.020346273,-0.038963683,0.06889506,0.047759425,0.027313754,-0.027654424,-0.0019521225,0.05686041,-0.056257937,0.05407841,0.02353849,0.05767823,0.0018184233,0.0029394089,-0.012314097,-0.012339116,0.059186816,-0.020769715,0.018064825,0.058169924,0.0068688802,-0.044493377,-0.0019278814,-0.009761426,-0.044475093,-5.0670433e-33,0.16339758,-0.09547857,0.010103222,-0.05398141,0.03942174,0.03550597,0.10433491,-0.07750152,0.058474593,0.0018990233,0.037735768,0.0033108965,-0.026946876,-0.061014965,0.05343283,-0.03929108,0.009525546,0.031608127,-0.020282954,0.0064945533,0.04275467,0.031167677,-0.015015657,0.07148492,0.08312136,-0.06198418,-0.031166423,0.042267337,-0.03716289,0.02935484,-0.016116422,0.041467562,-0.030036587,0.0026338059,-0.053786967,0.041437168,-0.112011015,-0.010571222,-0.019480579,0.01298509,-0.010713493,0.06336753,0.052626576,-0.02219777,0.0909975,0.054408245,-0.0810391,0.058273084,-0.049981654,-0.0069300192,-0.015345924,0.018640716,-0.057744242,0.016659793,0.017308401,0.055825945,0.03575783,0.08986818,0.062839,-0.036628097,-0.047990903,-0.009755826,0.0002052999,-0.0015491267,0.0113332365,-0.033392195,0.013690317,0.033745103,0.08937302,0.048481867,0.030486204,0.012415803,0.083345495,0.035706732,-0.009265612,-0.03230875,-0.07383729,-0.016972838,0.0026997507,-0.10353732,0.0016937365,-0.008568372,0.02856707,-0.03716015,-0.04016521,0.034949232,0.0023785331,0.08406011,-0.0045398357,0.004407312,-0.07201655,-0.074726984,-0.07356224,0.019920463,0.016295224,-4.9014655e-08,0.08717613,-0.029308183,0.035106946,-0.065941036,0.0040418473,0.005183884,0.091531105,0.033476595,0.04006293,-0.07440441,0.0223049,0.03700426,0.0628796,-0.04483583,-0.018439226,-0.004789421,-0.04349589,0.031709947,-0.0144948205,0.057347313,-0.028397094,-0.0011912999,-0.14151439,0.10450126,-0.0048362105,0.013651637,0.0681885,0.024097854,-0.02674989,-0.05112746,0.026077181,0.01471312,0.029800205,-0.060648583,-0.008644662,-0.04636213,-0.02413917,0.04767171,-0.058457986,0.08517398,0.014323994,-0.0668339,-0.004716617,0.009437604,0.014809946,0.017479032,-0.013899334,-0.011994817,0.018576397,-0.05205633,0.015200416,-0.0023943854,-0.088550836,-0.059474036,-0.07203558,-0.060080033,-0.059818774,-0.10542506,0.014732337,-0.019945761,0.100606285,0.05695108,0.16130362,0.0065833004 +3.1.3.46,"The enzyme copurifies with EC 2.7.1.105 6-phosphofructo-2-kinase. (cf. EC 3.1.3.54 fructose-2,6-bisphosphate 6-phosphatase).",384,1.0,-0.04384124,-0.021371758,-0.092216305,0.010574175,0.09646757,0.007281582,-0.04901865,0.06262088,-0.004451896,0.0120707825,0.029113537,-0.06465127,-0.09283936,0.046130873,-0.020768821,0.00758186,-0.073041655,0.0099538835,-0.015694877,-0.05653179,0.06617268,0.0107409,0.0024473865,0.011661265,0.037821863,-0.00672268,0.06655079,0.016951123,-0.022864496,-0.090181395,-0.051178254,-0.060223196,0.06231373,-0.0022031306,0.022806197,0.12934855,-0.004881946,-0.13061322,-0.04099959,-0.0132782515,0.030714441,-0.024478482,0.01563303,-0.0340647,-0.023072878,-0.015099877,0.0072880858,0.044077285,0.06055978,-0.0036737714,-0.047418043,-0.08769947,-0.012099675,0.058134012,0.0066177305,0.06913552,-0.10914612,0.013562142,0.0011906128,0.07627593,-0.012478081,-0.021089604,0.049012225,0.07481322,0.051936045,-0.041175365,0.008971677,-0.089079835,-0.06998866,-0.0033869145,-0.075295754,-0.043342993,0.06810558,0.03802646,0.04540891,0.06266009,-0.061630435,-0.017748896,0.034389995,-0.010417375,0.023899956,-0.0799484,-0.0037667379,0.045298822,0.0052356743,-0.04104115,0.015406024,-0.009807961,0.0017848404,0.030717185,0.07542776,-0.051526897,0.01740204,-0.076361254,-0.061062712,0.05664344,-0.040125474,0.11339711,0.011815495,-0.02824791,0.0016869869,0.070149325,-0.039392974,-0.06267705,-0.016774679,0.0008409245,-0.02862305,0.062354814,0.006392695,-0.0050120833,0.013695542,-0.02141404,0.07150182,0.014542893,-0.0006221318,0.12427345,-0.03821587,-0.11677389,0.015122034,0.022336487,0.047626257,0.0046843006,0.037747975,0.08451531,-0.060814083,0.04503085,-0.0975479,-8.440104e-35,0.022338228,0.048490137,0.061879773,-0.031582724,-0.01608642,-0.02345138,-0.04007967,-0.0048408355,-0.08247379,-0.042032637,-0.05606224,-0.023096023,0.08810875,-0.013056877,-0.028084783,-0.07168374,0.031164994,0.02257512,0.022067608,0.020115055,0.080217935,0.002059058,-0.0244742,0.022064235,0.020880546,0.09254704,-0.036380753,0.06948605,0.065909274,0.027168902,-0.012261213,-0.030539168,-0.03867962,0.03139597,0.025112545,-0.038659234,-0.0670451,-0.027926616,-0.0095169395,0.032700125,0.03674356,-0.008950311,-0.02825559,0.01746839,0.023324942,-0.08059019,-0.013909919,0.101571366,0.106904484,0.04263036,0.0143084945,-0.035454124,0.03071854,-0.0053696088,-0.010369297,-0.0032900118,-0.05922107,-0.039422803,0.067224525,0.002762231,-0.030307945,0.06405564,-0.06548949,0.04695515,-0.040480398,0.029451266,-0.08748572,-0.065596834,-0.06715231,0.12924802,-0.040190965,0.013108355,0.02341636,0.025055923,0.025688691,-0.048140105,-0.0052047814,-0.008983283,-0.10798133,0.04791327,0.021917392,-0.041857418,-0.00023566805,0.0100095095,-0.08483988,-0.06973119,-0.036370307,-0.038712062,-0.036639508,0.024897294,0.030908156,-0.060281202,-0.04448618,0.067161515,0.009893197,-1.8070114e-33,0.15492313,-0.07110152,0.07052313,-0.077369764,-0.02458627,0.07395956,0.082575,-0.04999656,0.07079118,-0.055690162,0.053140257,0.004674585,0.08035262,-0.081055164,0.029439472,0.0333417,-0.04864297,0.06794806,0.03603002,0.002757296,-0.016063297,0.037449617,-0.018348647,0.060762174,0.082794346,0.014587336,-0.030093372,0.038251545,0.014505845,0.027885754,-0.09002893,-0.049626913,-0.057251323,-0.02326195,-0.041170515,-0.025851004,-0.08562106,-0.031853296,0.043152664,0.016723193,-0.030134805,0.053889208,-0.0061972686,0.02889571,0.04084224,0.05036248,0.024450805,0.019251069,-0.0070133395,-0.063452005,-0.015403542,0.011897242,-0.035707753,0.06270571,0.025000082,0.06625981,-0.03842995,0.07484576,-0.019501153,-0.01471035,-0.038858775,-0.10535187,0.059810687,0.013185418,0.07191257,-0.017189423,-0.054033004,0.04362723,-0.012917544,0.064463265,0.021055108,0.0019039867,-0.01209904,0.026501272,-0.015680691,-0.0010813236,-0.078713134,0.044671014,0.021765597,0.0148939565,-1.886243e-05,0.069527924,-0.035339255,-0.033051305,0.041086234,-0.0040605757,0.06402807,0.046000954,-0.023690872,0.005349449,-0.08000156,-0.050279528,-0.06287881,0.015336916,0.07584682,-3.9959662e-08,0.058386795,-0.09868749,-0.00872256,-0.07895979,0.11018461,0.03444628,-0.024311636,0.01749287,-0.028118096,-0.005620599,-0.029771848,0.0894683,0.053250007,-0.015413398,0.024215246,-0.016217021,-0.03974913,0.06525973,0.0049117077,-0.0105598485,-0.0031755988,-0.09661096,-0.080894865,0.05173468,0.02113507,-0.016197216,0.021159627,0.04776844,-0.07435332,-0.010493413,-0.006129933,-0.0334084,0.010469204,-0.07665467,-0.044084493,0.056027308,-0.07761467,-0.031015785,-0.092481464,0.06490622,0.02919371,-0.0041709826,-1.2421957e-05,0.013008228,-0.04681932,0.015201132,0.10643458,0.0076418594,-0.034029026,-0.00011099798,0.030045131,-0.025394415,-0.08267236,-0.05831959,-0.01926324,-0.049479436,0.0098562995,-0.08140999,-0.035837464,-0.037065294,0.068114586,0.0606614,0.18456274,-0.008465587 +3.1.3.47,"Acts on the product of the reaction catalysed by EC 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, simultaneously dephosphorylating and activating EC 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH).",384,1.0,-0.11406014,0.025346084,-0.03578109,-0.03528408,0.03258289,0.015196542,0.011255482,0.026250452,0.016355932,-0.00878662,0.004262337,-0.051405266,-0.04805994,-0.022215836,-0.029818019,0.045524146,-0.04949139,0.007836235,-0.03996768,-0.027401086,0.021203188,-0.013718065,-0.0163178,0.02636394,0.026335666,0.024823437,0.071248956,0.022142952,-0.06083479,-0.13807544,-0.005316095,-0.040832784,0.015019288,-0.007265153,0.021651868,0.11170699,-0.048409406,-0.12761799,-0.0795993,0.040600523,0.07582177,-0.08722692,-0.04763405,-0.048520356,-0.03216449,-0.048411567,0.007400886,0.07179437,0.024499467,0.007588339,0.0050308187,-0.016966408,-0.034637444,0.030810943,0.040011548,0.009270168,-0.04158948,0.02062798,-0.033963233,-0.046024103,0.030656533,-0.08002333,-0.0032538779,0.0033451263,0.002810013,-0.06529115,0.08957576,-0.107228614,0.00026071686,-0.029210255,-0.09746203,-0.05426647,0.07406287,0.008540205,0.027641682,-0.03987376,-0.06504316,-0.050861053,0.04646483,-0.0256495,0.03228076,-0.01595043,-0.012752345,0.041636888,0.034328938,0.016992187,-0.037748728,0.005881822,0.01028324,0.034768067,0.03350147,-0.030462034,0.031238047,0.032171853,-0.11212378,0.0963689,0.04433896,0.078793354,0.012149841,0.015939761,-0.020643566,0.1233812,-0.08536704,-0.060006447,-0.014972226,-0.012903545,-0.0318622,0.09372796,-0.013173415,-0.011477161,-0.0133741945,-0.060731985,0.0062798476,0.042929318,-0.05891149,0.15490088,0.0007206623,-0.059128486,-0.03770455,-0.065027654,0.039595593,-0.010646477,0.011248378,0.049251508,-0.07041533,0.018344598,-0.1288338,3.3116398e-33,0.06346511,-0.009517935,0.04743401,0.026854252,-0.056875806,-2.7557531e-05,-0.08308015,0.033890974,-0.02202899,-0.12918909,0.002467509,-0.011117948,0.08837851,0.006268496,-0.028242279,-0.065017916,0.01621493,-0.009550292,0.0029975446,-0.029464703,0.095701925,0.023390781,-0.058213543,0.00023566275,-0.03646952,0.022860883,-0.057213012,0.052861717,0.04222342,0.046662375,-0.03251424,-0.04694076,-0.008597667,0.0648968,0.023039695,-0.03738324,-0.101492144,-0.022831144,0.049570058,0.061312392,-0.02623617,-0.006045132,-0.024819173,-0.058990616,0.015558366,-0.034175135,-0.018108152,0.12217416,0.06667906,0.0472097,0.034480665,-0.062229414,0.11981982,-0.03904052,0.025948072,0.04695515,-0.08231294,-0.056510493,0.015958259,0.04483025,0.004875631,0.09690241,-0.05804972,0.0722269,-0.03420568,0.039647557,-0.08661665,-0.012596241,-0.024468122,0.037435982,-0.006833579,0.046706773,0.13129434,0.0019676976,0.013143451,0.017785596,0.010467265,0.007098803,-0.06628682,0.11078613,-0.01579112,0.019108232,-0.047020968,-0.013547635,-0.038492907,-0.006766568,0.027341787,-0.084719844,-0.02662417,0.0721681,0.030785706,-0.07136384,-0.023477383,-0.050116953,0.031698737,-5.291802e-33,0.09993172,-0.018900577,-0.005019189,-0.088595755,0.007165023,0.02715476,0.070958525,-0.051402137,0.047328472,0.028541092,0.047486767,0.06779932,-0.00039617796,-0.0037782097,0.074374765,-0.045622244,0.016525598,0.037330765,-0.056946255,-0.03231296,0.014256567,0.045609474,-0.003706422,0.03602282,0.045615844,-0.076669164,-0.0034600284,0.047563475,0.03208025,0.031189676,-0.07160194,-0.010548256,-0.051682893,0.041724887,0.029357996,0.019627916,-0.07886867,-0.02608325,0.005137216,-0.03923817,7.0174574e-05,-0.032622643,-0.06303009,0.034525782,0.11302799,0.061137732,-0.023348464,0.03472152,-0.020684263,-0.09588726,0.023795158,0.03773841,-0.036939718,0.02161633,0.0049437215,0.047848955,0.014966172,0.0520636,0.0845931,-0.018248774,-0.007692616,-0.019042557,0.04658517,-0.011821325,0.030893747,-0.02829907,-0.01686037,0.033795472,0.03497995,0.07710483,0.10624467,0.04392242,-0.002163839,0.027052503,-0.0355017,-0.077423364,-0.08048439,-0.039746903,-0.07259589,-0.09047315,0.014009073,0.014498676,-0.0006442532,-0.045840073,0.0087125115,0.027384195,0.014423727,0.04593178,-0.05823007,0.009669114,-0.040140033,-0.0249845,-0.08555069,0.16203675,0.010684694,-3.8971375e-08,-0.019212093,-0.030813595,0.06151569,-0.05074422,0.1023272,0.06788351,0.034994926,-0.004010256,0.056495536,-0.028841494,0.008730896,0.089667484,0.12624155,-0.004457176,-0.009622686,-0.0015545428,-0.030236086,0.02084507,-0.010516241,-0.05345355,0.030275408,-0.06997808,-0.06918068,0.06463555,-0.008146756,-0.066914015,0.030011406,0.037975717,-0.012224839,-0.13119869,0.045833282,-0.006324863,0.04758509,0.036119506,-0.020511117,-0.0059975637,-0.05022383,0.0279666,-0.031135067,0.025769904,0.011685266,-0.045804847,0.0139676705,0.074734345,-0.014525218,0.0113481125,0.018381327,-0.0258385,-0.013977205,0.008611828,0.019847326,0.008219406,-0.046501007,-0.044015877,-0.043046135,-0.012231271,-0.03269231,-0.07130803,0.01257903,-0.045956258,0.0821497,0.031289347,0.1064015,0.026087303 +3.1.3.48,"Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.",384,1.0,-0.025775215,0.015315302,-0.021096427,-0.03228047,0.093376614,-0.027899528,0.049195047,0.044646822,0.10457385,0.027034901,0.064427935,0.01691555,-0.08632957,0.009975126,0.007508382,0.062199377,-0.08255291,0.03773398,-0.029145032,-0.056201864,0.033956748,-0.014911716,-0.003434722,0.049514133,-0.01230754,-0.037336137,0.053931914,0.09169432,-0.090596184,-0.046559468,0.017545654,-0.014115065,0.050412863,-0.0026587802,0.005548834,0.11599725,-0.020042917,-0.12446896,-0.07182993,0.004918464,0.074234724,-0.018989809,-0.04551156,0.015657675,-0.0065171584,0.027774908,0.05478673,0.053937092,0.042612534,0.02527523,-0.002266568,0.0006642716,-0.034759194,0.025283804,-0.011414523,0.11486321,-0.078659505,0.0714897,-0.033431012,-0.046699923,0.019466043,-0.011543665,0.091726944,0.032019358,0.034019724,0.019623615,0.10227237,-0.05780308,-0.013588776,-0.016093899,0.0008457332,-0.0033358873,0.10309455,0.06717681,0.0065356544,0.123687886,-0.057217043,-0.049957845,0.023823319,-0.10168851,0.063986465,-0.05294055,-0.002815942,0.01765356,-0.027222553,-0.0001916685,-0.05506036,-0.042322647,-0.012582676,0.019328125,0.006883659,-0.097765155,0.08605555,-0.06343174,0.0078005046,0.02257828,0.024168199,0.09889596,-0.06559123,-0.0392439,-0.060723335,0.064742185,-0.058928348,0.0070550395,-0.0032692861,0.014598639,0.050133534,-0.029285334,-0.05795932,0.015773939,0.01711731,-0.02741054,0.110473156,-0.03526123,-0.014123387,0.050094508,0.022241717,-0.016729152,-0.010403332,0.028836964,0.048413526,-0.015768442,0.025431799,0.088978924,-0.04763999,0.09409367,-0.038258687,1.7879873e-33,0.041725833,0.026490714,0.08371696,0.023140304,-0.004879189,-0.06658983,-0.017317463,-0.04244906,-0.010185519,-0.11505944,-0.09436808,-0.03222049,0.11315865,-0.009577532,-0.016885143,-0.036013488,-0.016951662,0.062288795,0.019888088,-0.006344489,0.044145714,0.054378398,-0.04253104,0.021396818,-0.0074499943,0.053863924,-0.09943273,-0.009163048,-0.0074053304,0.035933357,-0.032027278,-0.016700236,-0.043682076,0.021654502,0.008293183,-0.068999626,-0.09170639,-0.036559742,0.047125127,0.012965475,-0.025937922,-0.04334219,-0.059912246,0.001176773,-0.041463673,-0.051487263,-0.030295735,0.05775599,0.011843813,-0.01622185,-0.013348915,-0.089252375,0.025689362,-0.025726877,0.026843576,-0.10448872,-0.06255533,-0.050607674,0.03581309,0.058783047,0.003195382,0.0733493,-0.041592125,0.0060545546,-0.027231574,-0.048023228,-0.10550472,-0.05716986,-0.039493304,0.021141103,0.027800411,0.051208932,0.07405741,0.021187367,-0.03250304,0.057988938,-0.031361938,-0.008910658,-0.096119,0.08757261,0.011343502,-0.07433566,-0.008678042,-0.013557417,0.0040877094,0.037643734,0.07609804,-0.035688367,-0.021789484,0.047646414,-0.08560315,-0.029407272,-0.059832856,-0.03138631,-0.0023945963,-3.2095014e-33,-0.0016027202,0.0033609988,-0.0072601563,-0.03762325,-0.03620749,0.07211866,0.034741737,-0.05866858,0.084605075,-0.014006876,0.03791974,-0.043919712,0.021953925,-0.087946266,0.02589794,-0.057820458,-0.08141958,0.074017845,0.04600068,0.01701752,-0.0009207328,-0.054045282,0.02565811,0.10709658,0.07971352,-0.053180434,-0.06381046,0.023152653,-0.04004485,0.041519146,-0.04159548,-0.0016121449,-0.0024294448,0.04749077,0.01643628,-0.011466247,-0.07072481,-0.06016249,0.030253295,-0.053612303,-0.013313708,-0.0064954916,0.06996851,-0.0668696,-0.00438758,0.06948637,0.015802575,0.04583029,-0.026569169,-0.018928582,-0.00016360957,-0.0066276635,-0.04269911,0.06817894,-0.0022452178,0.07113667,0.008434285,0.097623765,0.029491505,0.018459614,-0.03122303,-0.069634415,0.026913667,0.051513426,0.050140087,0.0121865105,-0.019747922,0.050974026,0.0046499055,0.04225734,0.017606463,0.027773295,0.016222617,0.024143415,-0.008995353,-0.027019385,-0.07224923,0.008947614,0.043614503,-0.108796865,-0.07559917,0.010996073,-0.019675195,-0.034484394,-0.001401819,0.052898407,0.025325669,0.034819055,-0.06598721,0.06409497,-0.059707005,-0.048966948,-0.11402354,0.06621719,0.05824271,-3.4114088e-08,0.076504886,-0.0071329367,0.04141505,-0.021748707,0.06609841,0.010061817,0.058148608,0.07098461,0.038487744,0.026225725,0.08521408,0.014071683,0.051715776,-0.08505475,0.04453118,0.03413254,-0.0011336806,0.03932141,0.003288861,-0.058371797,0.08245401,-0.05822315,-0.07322231,0.026450804,0.031200528,-0.00076602364,0.013176327,0.009429238,0.020030113,-0.09334185,0.05022147,-0.10617926,-0.0006979978,-0.050772358,0.049989626,0.00031168034,-0.13623391,0.007372359,-0.046729315,0.082187034,-0.10356192,-0.007164935,0.018360818,0.018807298,-0.010698485,0.025938254,0.08225648,0.013784394,-0.04223602,0.00019314476,0.03199371,-0.0028774485,-0.022663094,-0.060638446,-0.13241458,-0.050687365,0.007959125,-0.019976297,0.02876529,-0.07447457,0.028529566,0.04290266,0.0862922,-0.0070096767 +3.1.3.49,"Simultaneously dephosphorylates and activates EC 2.7.1.40 pyruvate kinase, that has been inactivated by protein kinase.",384,0.99999994,-0.049448013,0.058046497,-0.032230433,0.057689346,0.057514604,0.018775983,-0.024599336,0.009452607,0.05703974,0.055537812,0.015120193,-0.03398768,-0.106298395,-0.008861664,0.015306238,0.01073117,-0.056929566,-0.014934552,0.017241698,-0.04833746,0.029403621,0.017118033,0.0064120055,0.054602865,0.022441892,0.005430721,0.07869326,0.10244917,-0.03262624,-0.06892718,-0.020896483,-0.06633156,0.032662135,0.00686419,-0.015736222,0.17076303,-0.081234,-0.089690275,-0.04599188,-0.020496234,0.11516414,-0.0074897506,-0.05766383,-0.017716223,-0.034251016,0.076316416,0.019792767,0.03252444,0.019304186,-0.045889214,0.021482464,0.018229827,-0.035424996,0.03167202,-0.006055917,0.055914998,-0.062162817,0.047793135,-0.04034106,-0.04781305,-0.021135679,-0.03580556,0.06106162,0.009340392,-0.03639866,-0.03562811,0.09588314,-0.071187876,0.013948214,0.027453097,-0.08564232,-0.049861554,0.15508085,0.024132434,0.005619397,0.04336273,-0.084656,-0.06679895,-0.014376417,-0.070976734,0.043174326,-0.072710976,-0.0013220207,-0.020386104,-0.059922848,-0.035373736,-0.0037266533,-0.07013184,-0.03966031,0.046839308,-0.0024166019,-0.05496195,0.052080173,-0.010881454,-0.024174102,0.031074157,0.07490282,0.10373557,-0.028330594,-0.028596342,-0.03142318,0.124607794,-0.07313198,-0.0073066438,0.01701254,-0.034366306,0.031943113,0.03286523,0.01600828,-0.03935219,0.014868188,0.017822564,0.075296596,0.049289178,0.037293006,0.12620679,0.04018359,-0.047840398,0.019257618,0.04074692,0.054489493,-0.04303127,0.018326648,0.018797543,-0.1486677,0.032686207,-0.07848476,2.8363813e-34,-0.023012465,-0.043081965,0.061521422,0.03063504,-0.019407006,-0.053459592,-0.07269224,-0.037883036,0.031753547,-0.09278781,-0.06420929,-0.07744532,0.10745874,0.0038136025,-0.09553328,-0.07019012,-0.028456993,0.055832118,0.026749302,-0.043761477,0.089422904,0.006989565,-0.01699572,0.0040313373,0.010061851,0.07362954,-0.017373597,0.053590093,-0.0029342384,0.005261382,-0.059603266,0.0071785105,-0.017118208,0.03577655,0.0037656014,-0.053679522,-0.038481787,-0.03289675,0.054161638,0.047414046,-0.019205084,-0.0529271,-0.03360818,-0.05190007,-0.032896966,-0.03812409,0.017202795,0.10776682,0.015310994,0.018225957,0.08267251,-0.059249315,0.033376083,-0.061786957,0.02041325,-0.03809898,-0.047515895,-0.07103559,-0.00026872606,0.019569438,0.06838157,0.07737183,-0.05173572,0.032510947,-0.011384714,0.013299598,-0.11413621,-0.06280707,-0.07283932,0.00930067,-0.03996399,0.022151336,0.1221622,-0.070220314,-0.021443112,0.035083894,-0.07566442,0.046547,-0.07129248,0.08867978,-0.0048044994,-0.0670865,-0.023895541,-0.003195698,-0.0074690524,-0.018676529,0.010702051,-0.05784619,0.03366294,0.015969511,-0.056239482,-0.010232351,-0.014555768,0.03897633,0.0058682454,-2.7866282e-33,0.06287129,0.019273441,-0.0111058345,0.02726535,-0.0052849986,0.10515663,0.051550906,-0.035129134,-0.009445465,-0.04991117,0.052676383,0.0010292864,0.022332385,-0.019568218,0.052743725,0.017627057,-0.044794526,0.04975281,-0.036290064,0.003051446,0.0069563175,0.009393551,-0.03750464,0.06908565,0.053815693,-0.027749807,-0.013688673,0.041546617,-0.024681695,0.017901964,-0.024896542,-0.012134121,-0.026529387,0.012787545,-0.015365768,-0.037409075,-0.08679582,-0.053216886,-0.0003307065,-0.053291723,0.041245166,0.038097955,-0.006002469,0.026764017,0.052789293,0.03995188,0.048899047,0.012560718,-0.021314131,-0.019858232,-0.019605998,0.0022140124,-0.09366257,0.006027411,-0.001834967,0.06457227,-0.022412678,0.10294264,0.06364392,0.018309094,-0.044005238,-0.09126728,0.09001147,0.030869521,0.056670856,-0.02991658,0.0046442808,0.03614631,0.03521718,0.06445265,0.0534533,0.052924298,-0.060746655,-0.0009774448,-0.03226356,0.029520903,-0.03451661,-0.01937529,-0.0023753636,-0.08531243,-0.029785408,-0.0018518448,-0.0168026,-0.09316187,0.013742409,0.012524636,-0.008132036,0.040542997,-0.036065232,-0.0020101815,-0.048396803,-0.101772055,-0.078427084,0.061397206,0.042909514,-2.652655e-08,0.025362728,0.021606836,0.01270709,0.03009981,0.0757167,-0.024316242,0.048652463,0.0737595,0.015749099,-0.034800682,0.059746183,-0.009837524,0.12587076,-0.0054228315,0.054784797,0.020516,-0.0020693834,0.104044676,0.021155091,-0.02555629,-0.008550079,-0.1213668,-0.089842774,0.050179422,0.08817618,-0.067046836,0.035236456,0.09210475,0.010482578,-0.13343799,0.047241636,-0.03109528,0.037277516,0.008625119,0.035160437,0.019928992,-0.081721924,0.02909771,-0.013389747,0.05347068,-0.056301076,-0.032311685,0.006838108,0.040762987,-0.057461124,0.04944064,0.050075285,0.004570786,-0.047213614,0.017868958,0.038231272,0.025698978,-0.02986576,-0.040126212,-0.035068292,0.010673886,-0.06278919,-0.017947387,-0.017289389,-0.066814944,0.10221756,0.0046566087,-0.0043256106,-0.055707444 +3.1.3.50,"Acts, very slowly, on hexose 6-phosphates.",384,1.0,-0.010296268,-0.11800719,-0.00486258,0.001580352,-0.006249872,0.022095025,0.04143055,0.016547719,0.029901037,0.0814454,0.02068251,0.04098148,-0.084433064,0.07887491,-0.039577734,-0.0107185915,-0.050249584,-0.01715604,-0.04511676,0.040618967,0.10573383,0.012105765,0.012773681,-0.07986544,0.043934893,0.035921443,0.025461841,-0.011403918,0.03658249,-0.11003378,-0.02446722,0.014676639,0.0038465348,-0.06159348,0.031213418,0.15938939,0.01026426,-0.03673988,-0.011512633,-0.03547243,0.07307145,-0.07513866,0.010624952,-0.039562747,-0.029582491,-0.05614074,-0.012457941,-0.010435609,0.055414785,-0.02050158,-0.08448037,-0.10512467,-0.050434764,-0.025053252,0.008070783,-0.027294183,-0.12523536,0.026960734,0.023845594,-0.071154244,-0.01265755,0.00056047976,0.043589175,0.08956651,0.078380644,0.0006938263,0.04965137,-0.030572472,-0.024757216,0.022799278,-0.031227054,0.034278285,0.02412896,-0.009602067,-0.01620815,-0.03565943,-0.052139692,-0.10642299,0.014948278,-0.02804425,-0.012096948,-0.01750955,0.030817661,0.09459741,0.0002261703,0.051072545,0.020868022,-0.007828828,-0.060088262,0.03089413,0.03058898,0.020254986,0.012618467,-0.06686008,-0.0077244774,-0.010259712,-0.0027011584,0.025954599,0.009651283,-0.02647107,0.023078565,0.10338292,-0.04260339,-0.015495856,0.02697056,0.03722226,-0.065907605,0.08937197,-0.04327743,0.08126481,-0.04126969,0.01710177,0.01749489,0.0018417196,-0.024157379,0.08933696,-0.048847135,-0.0527522,-0.036898755,-0.021592585,0.03343783,-0.007949653,0.010461938,0.07566411,-0.03345209,0.050337512,-0.04308687,-3.9867346e-33,0.052539017,-0.0022079705,0.037978474,-0.009448896,-0.07964428,-0.025500301,-0.046841606,-0.05585534,-0.04857667,0.028938966,-0.027616624,-0.033774965,0.0578863,0.025984587,0.0068479697,-0.051289316,-0.0028600139,0.046013918,0.058469716,0.0041031726,0.037521984,0.05899726,-0.029614016,-0.0044296132,0.0165079,-0.0013993742,-0.047588453,0.035542857,-0.023349999,-0.028520962,0.06682687,-0.0050985417,-0.050208636,0.01883223,0.065402545,-0.005490461,-0.056542587,-0.020652287,0.007012027,-0.067966715,0.023144558,0.051412534,-0.057364773,0.011604465,0.028097669,-0.08051423,-0.029656671,0.07676828,0.031142067,0.056487054,0.09188317,-0.03116892,0.103829436,-0.008148944,-0.010775678,0.055017367,0.038622297,-0.033997696,-0.015186778,0.08113412,0.053917795,0.00088149525,-0.05028721,0.09076012,0.010364476,-0.0013119602,-0.08452293,-0.020128734,-0.037523713,0.082016446,-0.079327114,-0.038084302,0.058923602,-0.07756855,0.020314343,-0.022137767,-0.030429337,-0.011302131,-0.062993236,0.03503047,0.10404381,-0.1006778,-0.032354057,-0.06220711,-0.08524096,0.018441832,-0.021076601,-0.12691934,-0.025110945,0.059635147,0.09866504,-0.12770005,-0.10602642,-0.037166867,-0.0147276865,9.931478e-34,0.07224645,-0.02616073,0.05122274,0.08611996,-0.06685201,0.049247637,0.059653666,0.058031846,0.05182282,-0.03575286,0.03298212,0.052958038,0.0125438385,-0.06789337,-0.016930334,0.1006788,0.091482885,0.068974495,0.09861403,-0.041263252,-0.06247879,0.11085865,-0.023099124,0.0979062,0.023712747,0.042521246,0.014761428,-0.04218729,-0.026654303,-0.01940051,0.0194098,-0.015634155,-0.078816324,-0.06250401,-0.06711845,0.0075768502,-0.07551139,-0.0055464087,0.008394807,-0.063510165,0.03996748,-0.016117573,0.063823074,0.062335078,0.016369076,0.07095583,-0.023386281,0.04724628,-0.067658335,0.051049218,-0.030633416,0.023068264,-0.043262623,0.04121435,0.09004911,0.02274558,0.034704268,-0.07619237,-0.036977604,-0.004783544,0.032305926,0.0013640833,0.03024793,-0.008552954,0.046727132,0.047987457,-0.027620083,-0.0108784,0.04101054,-0.0018360004,0.038331043,-0.002515206,-0.043726347,-0.034001343,-0.034899652,-0.022779677,-0.06588257,-0.049563386,-0.0154590905,-0.041060742,-0.036490843,0.07036716,-0.021450317,-0.05967351,-0.0108197965,-0.015845818,0.008691049,0.05193684,0.012015203,0.043860614,-0.011171649,-0.02492121,0.031150708,-0.007057561,0.034048982,-2.0247304e-08,0.05586751,-0.06600157,0.10105177,-0.066404745,0.0058637206,0.010788312,0.030475475,0.07895177,0.0469887,-0.014924239,0.010077645,0.055765882,0.089470245,-0.052117277,0.073766984,-0.04027968,-0.047617707,-0.029399134,-0.09494765,-0.0818846,-0.0898987,-0.043666206,-0.048074532,0.082015246,-0.00289012,-0.042341135,0.045916542,0.05500719,-0.010989235,-0.013748356,-0.0014534192,-0.00341598,-0.03620447,-0.057359908,-0.07734391,0.09514442,0.022204291,-0.008175865,-0.013036201,0.01425452,-0.054531418,-0.05708134,-0.033257503,0.014350509,-0.07622185,0.06688807,-0.03154019,0.008335955,0.014005224,0.01135583,0.010209112,0.017445877,-0.11928824,-0.02996894,-0.06240662,0.04506064,0.015022836,-0.052508373,0.07836762,-0.037607174,0.060963284,-0.033892423,0.12416922,-0.050320778 +3.1.3.52,"A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. Simultaneously dephosphorylates and activates EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), that has been inactivated by phosphorylation.",384,1.0,-0.04032985,0.01831522,-0.074848324,-0.018324748,0.05689669,-0.027529603,-0.04623284,-0.011981886,0.0007793232,-0.0057947068,0.077073365,-0.06156209,-0.008169122,-0.06957319,0.006226038,0.09496299,-0.08610881,0.01720335,0.030722717,-0.037366424,0.04656676,-0.0062934086,-0.031259254,-0.052421927,0.020169204,0.036911856,0.038221233,0.048620515,-0.046556402,-0.048169114,0.007830206,-0.066164985,-0.03818659,0.014339249,-0.0054598977,0.13384765,-0.03636375,-0.06445835,-0.008027762,0.032338105,0.11100858,0.063753806,-0.042201184,-0.015147082,-0.054719552,-0.012605871,0.005668043,0.03490156,-0.0075284727,-0.045321863,-0.010560806,-0.043403693,0.008329277,0.08282311,0.008972135,0.07938084,0.010289057,-0.011346935,-0.09729454,0.045112174,-0.009639693,0.015183703,0.0261412,-0.015199551,0.089989506,-0.035022195,0.057532843,-0.08775981,0.0073505268,-0.06653634,-0.06719659,-0.06451108,-0.010591184,0.04760557,-0.06944327,-0.014252988,-0.0448133,-0.011900597,0.033868328,-0.069947466,-0.0016581098,-0.027012115,0.04689923,0.01967891,0.0011521938,-0.02779407,-0.03369233,-0.054190245,-0.009736732,0.089217365,0.01870481,-0.038296137,-0.0057624253,0.010598658,-0.038417816,0.05062446,0.07492298,0.1229094,-0.064998806,-0.024237446,0.006986512,0.11434556,-0.05086361,-0.06780077,-0.023281747,0.014352814,0.030105196,0.020121628,-0.03735205,0.03160541,0.0017439644,-0.02189228,0.013531326,0.026160752,-0.009104832,0.14252687,0.031867728,-0.05392526,-0.03707669,-0.07173308,0.024541533,-0.00929083,0.041805044,-0.024752814,-0.056574386,0.0205044,-0.11069887,2.3493853e-33,0.01125485,-0.019200392,-0.011871915,0.063406795,0.009558032,-0.02465876,-0.08228595,0.042989824,0.037526857,-0.0737965,-0.05851285,-0.015438266,0.07158721,-0.017430762,-0.0382609,-0.038778495,-0.04416011,0.044921823,0.11053037,-0.028947221,0.04080028,0.026545856,-0.024202142,-0.076653585,0.0067004864,0.0985684,-0.01843746,-0.049198598,0.07995136,0.036282208,-0.012314432,-0.09504139,-0.112388805,-0.022325072,-0.0093590915,-0.07114015,-0.06555046,-0.05292633,-0.019614175,0.043705236,-0.035533257,-0.04175893,-0.0005695564,-0.07102699,0.022260547,-0.065232985,0.033875134,0.028645812,0.04833297,0.07082155,0.039664466,-0.08856571,0.10861447,-0.06576628,-0.041127015,0.014977344,-0.038035437,-0.01241997,0.01586398,0.059002735,0.05947428,0.061324265,-0.016125875,0.0450674,0.1136516,-0.0041092597,-0.08668718,-0.08650475,0.008669909,0.009399202,-0.016448,-0.037787225,0.1293831,-0.012279369,0.011075039,0.024222659,-0.065672874,0.034483008,-0.03843719,0.032937877,0.024566036,-0.01217122,0.079619735,-0.02727675,0.06841584,0.032801453,0.025396751,-0.010825665,-0.07549974,0.015893798,0.046922147,0.035161383,-0.05948849,-0.045914825,0.07835451,-4.160077e-33,0.07049904,-0.053132217,0.02111739,-0.10436438,-0.021662295,0.09398925,-0.0021333522,0.010215294,-0.024401758,0.012636596,0.09496238,-0.006426137,-0.017714266,-0.07922708,0.08317861,-0.038546074,-0.040117137,0.07348274,-0.030696463,-0.041264087,0.119702235,0.053371303,-0.019185262,0.08091727,0.011923376,-0.034667477,0.004612682,0.01207785,0.024621757,0.016322019,-0.03442467,0.04240812,0.033277303,-0.009953872,0.022469262,0.024259182,-0.06672812,-0.0014282201,0.008447701,0.05673522,-0.024957689,0.04050188,0.012593144,-0.00941224,0.023829157,0.008139738,-0.16175756,-0.03172458,0.02017724,-0.030166794,0.039692797,-0.0021546066,-0.061424937,-0.011406447,0.061410747,0.026918903,0.004113909,0.0760834,0.025515687,-0.039926477,-0.07029375,-0.025625182,0.032504,0.0092566805,0.037364423,0.05832648,0.007130205,-0.011576882,-0.008360158,0.021545973,0.05081381,0.036123376,-0.05323059,-0.013831611,-0.032140218,-0.044741787,-0.022065239,0.041093625,-0.019549519,-0.028896222,0.02433796,-0.040436566,0.040187087,-0.09046123,-0.0016492682,-0.05301752,-0.02604692,0.075607985,-0.03195785,-0.0058196457,0.008046091,-0.059350144,-0.13959152,0.03912375,-0.032125995,-3.9380065e-08,-0.0156454,-0.02079395,0.080583945,-0.005332323,0.022592444,0.057471015,-0.014286885,0.030672517,0.029955886,-0.0037281008,0.09090166,0.03992133,0.040950306,0.03132202,0.068825014,-0.016242044,-0.006471685,0.03388334,0.0022889331,0.00048073358,0.013762306,-0.05001545,-0.08904469,0.07864027,0.093828045,0.0107069705,0.011848982,0.0022669162,0.039886847,-0.058160417,0.04451062,0.0054804455,0.02481199,-0.029094936,-0.06596487,-0.030010143,0.00087302807,-0.0412684,-0.122693464,0.025716472,-0.015836911,-0.020268897,-0.039379712,0.06392138,0.083158515,0.063733466,0.0048295683,0.02311864,-0.042615592,-0.013714751,0.032283906,-0.003986358,0.022153867,-0.03595833,-0.14199002,-0.0043724645,-0.04697864,-0.082985915,-0.05706764,-0.016198931,0.15707242,0.05178798,0.10396523,0.008478713 +3.1.3.53,"The enzyme is composed of three subunits. The holoenzyme dephosphorylates myosin light chains and EC 2.7.11.18, myosin-light-chain kinase, but not myosin; the catalytic subunit acts on all three substrates.",384,1.0,-0.015109752,-0.047336224,-0.05024607,0.008199156,0.09245951,-0.09541068,0.019883966,0.041032113,0.047131233,0.003914876,0.063015185,-0.047004465,-0.08030187,0.057650942,0.028156325,0.05689135,-0.09155583,0.04964962,0.0027252862,-0.10099693,0.088588215,-0.016538637,0.017169807,0.010050949,0.010769079,-0.03285961,0.08960143,0.059304755,-0.06176866,-0.09664826,-0.050689567,-0.098486826,0.019143997,0.008595739,0.041131947,0.123366974,-0.046943005,-0.1287169,0.01542429,0.005827802,0.08559353,-0.009222271,0.020990517,-0.05182722,0.01626013,-0.0026085547,-0.07424848,0.015314683,-0.012258933,0.021645434,-0.0022834663,-0.084556356,0.014293952,0.0261477,0.009389065,0.08194099,-0.09031276,0.06706415,-0.0036596404,0.029849784,0.08002075,-0.00068329484,-0.022743993,0.011382608,0.084587984,0.03625726,-0.014827341,-0.0332074,-0.0046428954,0.0065439874,-0.007286913,-0.038389046,-0.015258558,0.093549706,0.0060526934,-0.023450065,-0.028402645,0.022137484,0.016922686,-0.01792629,0.017727233,0.04318881,0.0125639485,0.029143855,0.057404015,0.027056947,0.047771517,0.044768963,-0.03836876,0.05161,0.021987393,-0.053573266,-0.011765571,-0.03901944,0.012194145,0.04592322,0.054811753,0.08459935,-0.02547193,-0.039770152,0.078163154,0.015545477,-0.0064157,-0.05755934,0.0016662613,0.049404617,0.035196923,0.070495516,-0.0323264,0.052014872,0.002229391,-0.013207609,0.0858942,-0.029904233,0.015925778,0.10785573,0.006712749,-0.0073041962,-0.0012545415,0.109234944,0.05563144,-0.027587363,-0.0010100757,0.06658825,-0.06521408,0.024571555,-0.089954115,1.4781486e-33,0.03115114,-0.018615127,-0.035936996,0.008599738,0.024470318,-0.080330275,0.021681705,-0.029858967,-0.1565399,-0.070702046,-0.07049307,-0.031560075,0.06209624,0.042977188,-0.06525644,-0.036104534,0.0065408447,0.009121834,0.062400285,0.0689344,0.007288182,0.015265309,-0.08324762,-0.042930204,-0.026479665,0.01313251,-0.09926964,0.014918884,-0.0061867298,0.0051212157,0.00044254606,-0.015727516,-0.04858575,0.064115874,0.034661118,-0.058810387,-0.056219265,-0.07604587,0.007743824,0.017184988,0.014155722,0.021536333,0.03129289,-0.017666668,0.032308456,0.013775436,0.0044605974,0.02260147,-0.02545982,0.026962996,0.04304324,-0.044707537,0.056620836,-0.08313108,-0.007700247,-0.02767263,-0.023697235,0.014397358,0.042009536,0.025180107,0.017472984,0.08226181,-0.040360503,0.083090134,-0.022665776,0.048707526,-0.13043198,0.0055862716,-0.014929875,0.051079612,-0.03827812,-0.031515587,-0.010712768,-0.032561287,0.051124193,0.00094425486,-0.06128268,-0.007751862,-0.09811591,0.07527154,-0.035411704,-0.048281435,-0.08143461,-0.019779842,-0.0016966889,-0.00180791,0.011995119,-0.058600243,-0.05224201,0.00767569,0.021774685,-0.032417785,-0.0018794626,0.058933213,-0.007340615,-3.4993236e-33,0.07550445,-0.04027379,0.107328035,-0.10084689,-0.07974432,0.07350057,0.03193019,-0.0625336,0.03898905,0.089441836,0.109487966,-0.021462286,-0.08338178,-0.044651277,-0.0075318683,0.05047599,-0.07655106,0.06120732,0.0941598,-0.004348374,-0.0758409,0.07011386,0.01335115,0.028239062,0.004029284,0.00968991,0.04259849,0.053983387,0.049827386,0.011660244,-0.08141356,-0.042546425,-0.037229456,0.00408576,-0.06366499,-0.020558894,-0.04986979,-0.08106844,0.051079273,-0.0576962,-0.0041026333,0.026285386,0.033034574,0.047518235,-0.02086635,0.07318957,-0.04423841,-0.016068174,-0.12524481,-0.07525221,-0.06648058,0.0024961752,-0.026970582,0.06207906,-0.020660989,0.049682777,0.08363731,0.070307285,0.06833024,-0.01715503,-0.05151218,-0.034787245,0.026950292,0.06498276,0.049916007,-0.00096148875,-0.06656606,0.04887702,-0.005242757,0.014889654,0.024590788,-0.010457938,0.0011681018,0.037816957,-0.0024974702,-0.035302766,-0.05488151,0.022717314,-0.006416258,-0.090116456,-0.0068263016,-0.009060961,-0.058562454,-0.08941684,0.019786894,-0.06421628,0.08376096,0.09068628,-0.06296787,0.03843914,0.07895838,0.062864445,-0.0619198,0.020827485,0.04213063,-3.347003e-08,0.03813948,-0.060603086,0.029829944,-0.063374825,0.018289415,0.020802677,0.05312525,0.087167084,0.02176848,0.05907422,0.012576532,-0.004078702,0.010598932,-0.043654554,0.0207611,-0.0069743316,-0.06410162,-0.011161224,0.0032995148,-0.037846304,0.0013280913,-0.05089408,-0.049091898,0.045085497,0.029880984,0.0150325475,0.050114315,0.1151852,-0.015436839,-0.034480184,0.020487295,0.032045543,0.018930309,-0.0365864,-0.07697742,-0.0011752507,-0.124260634,-0.0638461,-0.059071135,-0.011483639,-0.011605333,-0.08369766,0.011013363,-0.002446438,0.0117476005,0.024702217,0.08155659,-0.000106562664,0.037807103,0.06187448,0.0151938135,-0.050003976,-0.04471935,-0.011380283,-0.05502494,-0.072948694,0.0058421614,-0.00820312,-0.0076286965,-0.025773522,0.086830266,0.026026871,0.104468346,-0.08484351 +3.1.3.54,"cf. EC 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase.",384,1.0,-0.010327951,-0.030017314,-0.111841105,-0.0013290262,0.09332707,0.006313793,0.016822837,0.07844417,0.044454586,0.015024099,0.0090753175,-0.056600578,-0.03686504,-0.019573992,-0.023491682,-0.07338308,-0.058601256,-0.071885884,-0.027097022,0.009789096,0.088877104,-0.007131736,0.008975249,0.023833103,0.066334926,0.0026458057,0.043811094,0.007021894,-0.040394377,-0.05335576,-0.04268779,-0.010994712,0.09686489,-0.037520695,0.05851853,0.07684774,0.026130864,-0.0609095,-0.052030265,-0.010421618,-0.0130825,-0.0013138045,0.06835316,-0.0085248165,-0.036918472,0.014142657,-0.036653023,0.062469803,0.055658914,-0.044067327,-0.030730003,-0.085078225,-0.033455234,0.07351619,0.040095735,0.058479495,-0.09088183,0.04110163,-0.01093816,0.08097513,-0.05030862,-0.03737668,0.05301462,0.036910806,0.10180631,-0.0023296778,-0.021741265,-0.082917936,-0.041675437,0.015909249,-0.09434648,-0.010913489,0.03825803,-0.02036588,0.023906467,0.02949359,0.016674107,-0.029798891,0.039675638,0.004556966,0.011833788,-0.06067929,0.0025137686,0.032481458,0.00068848307,-0.059619408,0.0022317625,-0.016652556,-0.020126346,0.052159715,-0.030285064,-0.05167908,0.07704634,-0.033350404,-0.071631365,0.116595335,-0.052054115,0.07533745,0.079243466,-0.027688514,0.010195454,0.0805549,0.0011440758,-0.026952295,-0.06836148,0.035677515,-0.049392447,0.094947964,-0.019851299,-0.004146267,0.04460875,-0.004694645,0.020593412,0.0044238428,-0.015313104,0.078860804,-0.008039145,-0.108415,-0.024414903,0.019044107,0.031075016,0.0087761255,-0.00930494,0.053415157,-0.059458546,0.0059281657,-0.074837424,-4.7925e-34,0.016752813,0.037025385,0.06712025,-0.055533487,-0.016935142,0.0058079897,-0.05008691,-0.026996236,-0.061855692,0.024098605,0.0031285237,-0.03539166,0.10214154,-0.03134824,-0.03280285,-0.0898931,-0.0023660448,0.041499667,0.036169797,-0.010634887,0.0306084,0.042676497,-0.0037161761,-0.0011552947,0.01227372,0.06723986,-0.08162864,0.04086151,0.08339414,0.007315758,0.08212505,-0.036869004,-0.09374265,0.016836759,0.00072138745,-0.07347374,-0.085164234,-0.035888746,-0.06406111,0.032935087,0.05055478,0.0043603876,0.0028451516,0.01918958,0.018319977,-0.072091155,-0.04014937,0.10194038,0.15144013,0.06956204,-0.011997937,-0.004640547,0.05711133,0.0060149585,-0.008913136,-0.006473864,-0.06356801,-0.04164192,0.017427899,0.01923466,0.0071814377,0.119399175,-0.050762217,0.01286329,-0.06202662,0.019755788,-0.06573506,-0.035075482,-0.02521037,0.09587091,0.016568283,-0.04968521,0.041022405,0.049192037,0.05878045,-0.021868197,-0.016536795,-0.025150776,-0.119343646,0.0619494,0.040214293,-0.021372657,-0.014827576,0.008191346,-0.10306254,0.007141491,-0.056417834,-0.066483185,-0.010399286,0.050663885,-0.020027796,-0.057765033,-0.055878695,0.054584578,-0.062418763,-7.778712e-34,0.13593623,-0.058857586,0.039575163,-0.11795734,0.010232366,0.032117642,0.070488006,-0.028009575,0.09042842,-0.045386378,0.06811025,-0.016985975,0.022997271,-0.08853472,0.010164036,0.017460493,0.008946541,0.02767566,0.049524654,0.018657908,-0.001640678,0.07109465,-0.019006474,0.106782116,0.06344051,0.025852319,0.007641544,0.004111867,0.029087681,0.06418692,-0.088000596,-0.02503212,0.009571823,-0.018828845,-0.059056055,-0.0435036,-0.09787872,-0.0673295,0.011242311,0.016983125,-0.010675311,0.07910832,0.07093707,0.032002877,0.046914883,0.06209852,-0.011342507,0.0688792,-0.027529743,0.030271202,-0.052351568,-0.0014142075,-0.06206108,0.05682372,0.030439539,0.04367421,-0.062406283,0.066751495,0.022651285,-0.05903056,0.008337462,-0.08472351,-0.00066934805,-0.009886077,0.047994953,0.0410607,-0.051485542,-0.0040019434,-0.013215691,0.063492894,0.016365768,-0.017298866,-0.01168573,0.01114078,-0.010263274,-0.048088726,-0.11420499,0.03679402,0.02324142,0.012490676,0.01431051,0.06605421,-0.011525767,-0.0003402788,0.068238914,-0.07716701,-0.015347814,0.030177563,-0.01832931,0.012187326,-0.08236161,-0.048633687,-0.035100345,0.018558841,0.07152264,-2.8242658e-08,0.079386786,-0.071584456,-0.0208712,-0.05652498,0.063506536,0.01071573,0.010410961,0.01085715,-0.04132631,0.0098295165,-0.017589143,0.093216136,0.06711141,-0.06508227,0.01275543,-0.024117181,-0.044842705,0.0054053646,-0.010449367,-0.01828753,-0.013246715,-0.026631633,-0.082283564,0.0343053,0.013016919,0.041650794,0.029170657,0.013426045,-0.057911213,-0.0059182215,0.04581603,0.007979243,0.028546209,-0.07993969,-0.04925076,0.035619546,-0.06648286,-0.024723046,-0.12288668,0.040415198,-0.015947942,0.0025831163,0.013056275,0.014739739,-0.0378563,0.018282438,0.025170472,0.07013351,-0.055291686,-0.027800912,0.0019737866,-0.023626924,-0.06544936,0.008151154,-0.038505144,-0.06561925,0.021372316,-0.08249754,-0.06874837,0.015848298,0.1120265,0.053321477,0.18303311,-0.043618746 +3.1.3.55,Dephosphorylation activates the calmodulin- and actin-binding ability of the protein caldesmon.,384,1.0,-0.04206893,-0.11373322,-0.014016042,-0.020898601,0.02196205,0.011379499,0.15535587,0.007893021,0.090138294,0.05488056,0.027924266,-0.021373384,-0.03304911,0.07004952,0.039644495,-0.034719706,-0.057791688,-0.033461366,0.025762796,-0.02254669,0.07443467,0.03160533,-0.06356869,0.028419914,-0.057687487,-0.025866985,-0.053756133,0.060594894,0.030769797,0.020547371,-0.0039951205,-0.04883368,-0.0072293407,0.008822061,-0.05190795,0.09487271,-0.03178878,-0.05321592,-0.06534026,-0.055898096,0.06928701,0.054607365,-0.012488994,0.02497194,-0.08630611,-0.009488398,-0.051337015,0.051495552,0.02895194,0.03173206,-0.033766277,-0.00940952,0.0119964555,0.071195245,0.014103438,0.053304136,-0.038071357,0.030039633,0.03249881,-0.026281163,-0.06975317,-0.019926945,0.049494088,-0.05189314,0.07029098,0.02651731,-0.026487218,-0.028241837,-0.026933245,0.048296332,0.033410896,-0.02805177,0.06982428,0.013027921,0.019154895,-0.034190673,-0.04573424,-0.018768076,0.0036742624,-0.011337537,0.026626535,-0.046724804,-0.023201365,0.09540196,0.01367018,0.040478177,0.0029042745,-0.03260569,0.019713555,0.018494362,0.03730476,-0.04101439,-0.006460199,-0.024510918,-0.075187676,-0.0065798317,-0.04663885,0.012209682,-0.043892678,-0.010949411,-0.056922305,0.070769235,-0.0536878,-0.025626907,0.04154669,0.020406533,-0.011661547,-0.016843084,-0.07768792,-0.011669759,0.029515017,-0.027831767,0.0980713,0.098126285,-0.012136101,0.07080661,-0.08844165,-0.013559118,-0.009695603,-0.07360317,-0.007368207,0.07252417,-0.038925063,0.021248784,-0.045994766,0.010013724,-0.11651611,-1.728881e-33,0.049730405,-0.04444944,0.020636724,0.05444521,0.004908917,-0.06507773,-0.034696355,0.017876605,0.047212854,-0.034930717,-0.022010466,-0.045226287,0.05136775,0.046600807,0.015988264,-0.07477795,0.024912301,-0.014637873,0.043972906,0.04005277,0.044070616,0.04971761,0.004166539,-0.08702284,-0.009488278,0.12425522,-0.06500294,0.10550825,-0.0226105,0.012112784,-0.02663618,-0.03843986,-0.044504136,0.05522505,0.12437595,0.014824035,0.012171313,-0.026748208,-0.008850588,-0.010831957,0.0007055071,0.024526643,-0.061575472,-0.014038012,-0.029502189,0.01564611,-0.04147712,0.04302296,0.041735865,0.03560715,0.04385489,-0.0035193916,0.08787061,-0.101013236,-0.091171995,0.02684562,-0.040363602,-0.08918238,-0.045085873,0.021361077,0.021472516,-0.09523128,0.015512134,0.028522726,0.03605412,0.04457706,-0.09934556,-0.10453914,-0.016704135,-0.008373396,-0.07288862,0.035356313,0.08299021,-0.026468508,0.04804818,0.032457974,0.008358627,0.026144953,-0.09725695,0.039133072,-0.020034699,-0.06203615,-0.081500925,0.07687836,-0.028554069,-0.030362938,0.05513122,0.013357376,-0.025646672,-0.0007732543,-0.028559452,-0.07339252,0.0052722534,0.08708338,-0.14386263,-1.3141371e-34,0.0053788214,-0.06743105,0.045035075,0.026909066,-0.026863148,0.07163789,0.017298555,-0.011591938,0.033265445,-0.01450317,0.05851475,0.012108966,-0.10933315,-0.065268114,0.024693616,0.13174757,0.017486198,0.016448615,0.0037965213,-0.10670771,-0.023214553,0.09953979,-0.021194734,0.049447544,0.030778162,-0.06269928,0.0153249,-0.02241018,-0.023954248,0.051237654,-0.06410306,-0.00022721977,-0.039727807,-0.043091707,-0.026800685,0.022278165,0.009333122,-0.01893136,0.011583355,-0.043526106,0.06597707,0.06192833,0.021214161,0.11877745,0.059015,0.059340447,0.002809858,-0.003916937,-0.12757297,0.1097404,0.0691261,-0.10121949,0.036360603,-0.043263573,-0.004789422,0.021249622,0.03031136,0.0595831,-0.043938547,0.06259985,0.011924659,-0.032654047,-0.009475483,0.047383938,0.028401932,0.04780003,-0.03978188,-0.043636624,0.06732835,0.022722637,0.08795565,-0.014458947,-0.006812266,0.054959524,-0.045947153,-0.0336739,-0.016570225,-0.025010148,-0.0014530917,-0.035604514,-0.07156895,0.06140507,-0.0046752137,0.0065071234,0.024513284,0.11015131,-0.012382308,-0.004678148,0.0029187242,0.019730665,-0.074596785,-0.009144909,0.004326534,0.022160996,0.009421148,-2.3138629e-08,0.045862444,0.0225154,-0.06412499,-0.021963863,-0.071748726,0.016926954,0.04306711,0.0075082066,-0.022810047,0.0011196207,0.07535276,0.013853041,0.029968513,-0.03018229,-0.027366703,0.08915289,0.034918103,0.015392173,-0.03459358,-0.012165498,0.051337272,-0.010635369,-0.011100217,0.063403286,-0.0018207786,-0.020658413,-0.012549711,0.037407268,-0.027317924,-0.022961413,0.032840867,-0.0074419817,-0.07663991,-0.05919157,-0.008902712,0.0009148879,-0.104274005,-0.08971578,0.016678626,0.13916565,-0.032814156,0.06813481,-0.0039727082,-0.010475357,-0.04653361,0.03805298,0.009706316,-0.022035597,0.071116135,0.09254598,0.08398831,0.048494045,-0.025812492,-0.06552747,-0.17121023,-0.014206842,-0.0029682342,-0.01797183,0.02124827,-0.0036055758,0.098843664,0.044202995,0.051722538,-0.06736915 +3.1.3.56,"One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.",384,0.99999994,-0.083577156,-0.053283338,-0.051438954,-0.03264112,-0.033480357,-0.03599708,-0.017064054,-0.0010534407,0.030475833,-0.010898555,0.03711754,-0.05400782,-0.12638572,0.052786928,0.010272595,-0.041612197,-0.08195512,0.0012317507,-0.004893677,-0.04729266,0.104857385,0.016132664,-0.021206092,0.04743785,0.05739391,-0.06502175,0.08674437,-0.019491222,-0.06664308,-0.0942462,-0.060998015,-0.10792625,0.08958007,-0.049427915,0.02708419,0.035345677,-0.060802627,-0.03615405,0.039759208,0.011221165,0.06320718,-0.050473668,-0.050488736,-0.017887676,-0.030957442,-0.024741204,-0.06609962,0.0215408,0.08376146,0.036648043,-0.027130991,-0.0859953,-0.047939323,0.061954364,-0.08078711,0.011445676,-0.06925223,0.04330719,-0.026028844,-0.018629251,-0.0071236705,0.0015196584,0.070051946,0.04451338,0.015380993,0.04006217,0.05680136,-0.07565838,-0.023703644,-0.013963373,-0.015680514,-0.08898992,-0.02022733,0.06783864,-0.051437028,0.060151502,-0.0005162629,0.011671165,0.010741461,-0.042252578,0.02730339,-0.013864934,-0.026099278,0.059164073,0.053606357,0.017136067,-0.06910132,-0.029272482,-0.030961916,0.00023462389,-0.016879208,-0.046574347,-0.003666102,0.0021500199,0.05132375,0.058543377,0.028381415,0.08379197,0.035182126,-0.03366266,0.0030457696,0.06121754,-0.09371661,-0.04626783,0.01021756,0.04507044,0.01609058,-0.04635886,-0.0029359974,-0.0060595875,-0.012594541,-0.049019564,0.0057778605,-0.02398574,0.0560628,0.045551863,-0.018304983,-0.05395238,-0.009084162,-0.012232865,-0.016504064,-0.03372203,0.022620263,0.05731642,-0.037290864,0.07564401,-0.07580868,3.288244e-33,0.007051159,-0.021755327,0.0019470608,0.046787504,-0.040523455,0.028324757,-0.020079916,-0.0017032984,-0.0798854,-0.083802246,-0.06569958,-0.06033244,0.053186234,-0.009443279,-0.02090841,0.0016571705,0.015315452,0.096555896,0.0947243,-0.016499188,0.02127597,0.059513725,-0.024772638,-0.03785974,0.036108878,0.049549464,-0.14188316,-0.015949225,0.033788245,0.01863949,-0.03351731,-0.06368107,-0.08731678,0.016731087,-0.037208628,-0.045433104,-0.039499078,-0.050169192,-0.02033533,0.039149992,0.041448813,-0.034196485,-0.012114732,-0.065134756,0.029169956,0.04617528,-0.07113905,0.023078887,0.080833584,0.00802913,-0.04324431,0.009318096,0.103674054,-0.061582956,-0.020164808,-0.04241322,-0.002931918,-0.033411775,-0.029774837,0.06129969,0.019421834,0.13854432,-0.041932907,0.043549594,-0.02555871,0.029594742,-0.13826771,-0.04270397,-0.030373482,0.093706615,-0.0032029497,-0.010475863,0.0065925396,-0.028841471,0.03036853,-0.04219053,0.00058937434,0.0030645514,-0.07784455,0.05265927,-0.044011667,0.01908388,0.0045926543,0.025907999,-0.03733853,0.03884012,0.03748839,0.008159261,0.029336235,0.069187,0.04638177,-0.023562666,-0.12813415,0.05522058,-0.0124262795,-5.2115597e-33,0.037705444,-0.05512788,0.06720776,-0.11279288,-0.07355717,0.11351294,0.011845483,0.029542455,0.0967933,0.054130327,0.0516533,-0.030979453,-0.017050248,-0.06877273,0.03614587,0.021123176,-0.06367612,0.008193999,0.056454293,-0.0064036883,-0.016513357,0.04667271,-0.03634782,0.119072914,0.084163345,-0.0042858543,-0.022851055,0.048545085,0.020541573,-0.021629706,-0.09347781,0.025376745,-0.01180694,-0.022890616,0.010050463,0.026763173,-0.062901884,0.023020504,-0.01528781,-0.048838604,-0.055302314,0.09380912,0.0400027,0.050140865,0.014623365,0.020516735,0.012559541,0.07561855,-0.050014555,0.029300947,0.00802668,0.0053428304,0.017983165,0.08090422,0.045026798,0.07912242,-0.049359962,0.11060034,0.006808766,-0.04186971,-0.03126139,-0.056270067,0.036993075,0.040490188,0.073734954,0.013039743,-0.06980174,0.01149061,-0.032217976,0.03879252,0.07197323,-0.024400415,-0.03805413,0.018228035,0.027306722,-0.0055496925,-0.04381284,-0.0077460664,0.0071715172,-0.037757084,0.020989852,-0.006745669,-0.008450522,-0.04175067,0.015872274,0.0070135444,0.008644921,0.1002102,0.037304092,0.08398127,0.0126601,-0.06199368,-0.12626712,0.025900489,0.036371596,-3.818978e-08,0.07278566,-0.048512973,0.049829252,-0.08251781,-0.005370233,-0.0025038484,0.048392832,0.01550245,0.04283668,0.05087759,0.02116893,0.03843632,0.054346994,0.021306556,0.037211083,0.033653736,-0.040224142,0.10203122,0.02381977,0.035007283,-0.041128993,-0.033574592,-0.11146615,0.028430698,0.037990488,-0.020080477,0.051749654,0.0684083,-0.026626443,-0.026189512,0.0057278513,-0.01274646,0.011113366,-0.02960024,0.00013631223,0.02325917,-0.018096918,-0.027659854,-0.09118081,0.09997856,-0.07010273,-0.059117194,0.004520885,-0.0070312927,0.023732573,0.018420361,0.016402096,0.024015434,0.013885703,-0.047813218,-0.08404643,-0.04122378,-0.040283028,-0.06496319,-0.09376436,-0.048845425,-0.031493854,-0.04233692,-0.0017604616,0.0021987278,0.09159761,0.06556664,0.21089159,0.0014831191 +3.1.3.57,"The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.",384,0.99999994,-0.0390914,-0.10060485,-0.06356499,-0.07454757,0.03979421,-0.04652863,0.014550989,0.044980373,0.035941582,0.00066679507,0.0013827633,0.0040386454,-0.05345197,0.09961551,-0.018111309,0.06208404,0.022132799,0.005454229,0.0027861726,-0.06834509,0.0993519,-0.08250775,-0.017761318,-0.000922267,0.037603687,-0.011056783,0.017098617,0.0083627915,0.018202927,-0.092503995,-0.103385516,0.012713724,0.0648112,-0.027222529,0.038540997,0.15658523,-0.09593963,-0.07725851,0.02787577,-0.004383296,0.056116264,0.0016529129,-0.04512323,-0.019468315,-0.055360578,-0.031997696,0.0068213088,0.030176446,0.0500071,0.011677626,-0.02797886,-0.040530164,0.008736686,0.020890387,-0.06714234,0.001881151,-0.08909053,0.10434132,-0.02344258,0.028765807,0.034567628,0.0065080617,0.016260777,0.050603848,0.062271636,-0.031215217,0.043282244,-0.01168864,-0.070490554,-0.0162389,-0.028063053,0.029342124,0.022798646,0.053575054,0.059082616,0.004597982,-0.031405814,0.020536147,0.0351324,-0.02456399,0.012043082,-0.02317091,-0.013381411,0.010804835,0.028158806,0.021488385,-0.05387471,0.03968614,0.07539831,0.0599616,0.053462796,0.013055131,-0.036442157,-0.021673836,0.007939426,0.028036343,-0.04677553,0.04167603,0.007629047,-0.024638083,0.027423589,0.043668933,-0.06573855,-0.041923944,0.024412017,0.0086913835,-0.012303096,-0.02622787,-0.009399099,0.0013614369,0.0034472458,-0.03284807,0.17207812,0.027053198,-0.04315997,0.09720133,-0.015533686,-0.034631826,-0.00030186595,0.027427685,-0.0010905043,-0.0765884,0.0032833656,0.09586013,-0.102145895,0.11040263,-0.041490465,5.883982e-33,0.015689353,0.034309357,0.023152916,-0.03361186,-0.045186598,0.03090225,0.013436929,-0.0049862154,-0.17684753,0.0024502408,-0.043790296,-0.05771346,0.09826897,0.013188461,-0.00974991,-0.0048744883,0.0025048272,0.032359667,0.054909192,-0.0062722047,-0.0010780878,0.05530653,-0.12655592,0.008542799,-0.0025484152,0.11090913,-0.10109868,0.051486146,-0.030796448,-0.01279322,0.060671806,-0.034426633,-0.122642785,0.04237818,0.025436265,-0.035993874,0.0051799035,-0.007116585,-0.054267332,0.014760321,-0.021297447,0.042385668,-0.008276561,-0.0098781185,0.009159963,-0.07428424,-0.005171176,0.056651965,0.041535143,0.02301551,0.040542454,-0.013401551,0.08566569,-0.10652984,-0.06655602,0.05145701,0.028991206,-0.01966779,0.038644664,0.044146817,0.0019069737,-0.031991404,-0.03492986,0.008690137,-0.019928949,0.029318053,-0.06534934,-0.09821398,0.015024078,0.13576071,-0.021434633,0.015508608,-0.05584351,-0.029655281,-0.012891954,-0.029363725,-0.009898234,-0.009472176,-0.021327943,0.007913028,-0.0017324346,-0.062166926,0.06174398,-0.023870364,-0.11840666,-0.013991971,0.07051035,-0.10581053,-0.00585244,0.02382399,0.09425615,-0.05559742,-0.04717772,0.021594064,0.038691007,-6.412514e-33,0.058026228,-0.023321947,0.036269497,-0.079467215,-0.1273302,0.09276639,0.091305956,-0.05040256,0.052123744,0.04042419,0.11263975,-0.05033425,-0.055087134,0.0017330671,-0.017326618,0.063900545,-0.020040844,0.017932815,0.04879268,-0.014091687,0.0042438013,0.11622428,0.046284877,0.14175645,-0.01912466,0.007859033,0.0022209163,-0.019457113,-0.0075015267,0.06271018,-0.04744345,-0.034188617,-0.034089517,0.030334892,-0.025679339,-0.023139616,-0.020964798,-0.037350688,0.018737,0.024032395,0.00419694,0.091235265,0.014522383,0.07342504,-0.029025735,-0.011428787,-0.0006432925,0.0638719,-0.04339041,-0.05282456,-0.043476444,0.025158472,0.02630306,0.06886725,0.043702,0.03627868,-0.030111734,0.018873733,-0.07572257,-0.05576438,-0.05297795,-0.09236351,-0.0074875248,0.014674272,0.064696014,0.092157885,-0.062861495,0.0071414523,0.01629603,-0.010399134,-0.016462026,-0.03214885,0.010195029,-0.011684737,-0.050534613,-0.040071152,-0.061232604,-0.021091504,0.00079731306,-0.040645868,-0.064945444,0.049736213,-0.06504156,-0.052886162,-0.027927369,-0.039653506,0.019523617,0.13141021,0.05614913,0.062405422,-0.005646682,0.0062611992,0.0035328832,-0.011660535,0.04890184,-4.66075e-08,0.047844917,-0.02519641,0.0151526695,-0.022297025,-0.021794293,0.018346565,0.023682738,-0.039605156,0.031452447,0.056911662,-0.036597956,0.05121035,0.02148302,0.016814975,0.12079271,0.025823563,-0.06615391,0.02947653,0.0007375216,-0.02673394,-0.045139093,-0.008705668,-0.092219606,0.037869535,0.043822464,-0.014186851,-0.00369051,0.061187,0.016459683,0.03605254,-0.038431507,-0.0010415408,-0.04505697,-0.065762036,-0.060587246,0.06113127,-0.09456635,0.048086576,-0.08469943,0.04028989,-0.053242788,-0.085458204,-0.04127708,-0.011712969,-0.037747927,0.06462411,0.032844882,-0.00899542,0.06646124,0.00073649583,-0.016224733,-0.038115297,-0.01200281,-0.059543412,-0.03290647,-0.058771484,-0.037606172,0.0060761375,0.011344122,-0.045722276,0.034897815,0.040226616,0.09029231,-0.074750826 +3.1.3.58,"Acts on sugars and polyols phosphorylated on the terminal carbon, with a preference for sugars with a D-erythro-configuration, e.g. good substrates are glucose 6-phosphate, mannose 6-phosphate, 6-phosphogluconate, erythrose 4-phosphate and xylitol 5-phosphate.",384,1.0,-0.006632515,-0.07639915,-0.056810256,-0.029585103,0.011637302,0.09032375,0.10338656,0.015174481,0.014121898,0.118328504,-0.014770178,0.01449885,-0.1282655,0.020459637,0.040167287,0.024753623,0.0019387245,0.050534304,0.009868246,0.024659308,0.14026743,-0.054773502,0.028947433,0.011796378,0.05612045,-0.06734151,0.020380134,-0.045621797,-0.001746417,-0.115314506,-0.05667893,-0.010012746,0.0012565687,0.024827855,0.008087575,0.117136665,0.003522291,-0.076472074,0.00405933,-0.0500983,0.05794055,-0.066466436,0.06470026,0.009572675,-0.038231865,-0.027483802,-0.06885922,0.091376685,0.018154185,-0.09007524,-0.04107892,-0.06430307,-0.04870939,-0.026253095,0.023085855,0.09619963,-0.014033394,0.0125395935,0.051754564,-0.01218301,0.006893384,0.009572438,0.027934797,0.04759493,0.023466606,-0.030910626,0.03061672,-0.02339567,-0.040602658,0.015119296,-0.11222379,-0.05271063,-0.04304959,-0.005488798,0.068724506,0.008781305,-0.0078118956,-0.020456763,-0.021847319,-0.006126975,0.024519548,0.057983395,0.05941171,0.087446705,-0.06387067,0.02571239,-0.049264763,0.00012898997,0.0070918724,-0.0064119967,-0.022562897,-0.04046358,0.012615509,-0.010466539,-0.09869381,-0.0077090003,0.08153515,-0.011032614,0.115775175,-0.0059485016,0.059663232,0.05078766,0.022933915,-0.032601442,-0.05146477,0.017605584,-0.03448019,0.04026335,-0.015368973,-0.016432455,-0.0479465,0.0670213,0.00935667,0.049066063,-0.094914824,0.014810512,0.050207574,-0.09009398,-0.04545079,-0.04599081,-0.03019266,-0.032601617,0.041550335,0.046678353,-0.039900627,0.0019008734,-0.010834,1.0745215e-33,0.092003986,-0.041840456,0.05128233,-0.041940656,0.04394054,0.046225004,-0.05397886,-0.061070453,-0.04789616,0.006546992,-0.08824171,-0.029819144,0.013565747,0.09953448,-0.0034323628,0.013219049,-0.0453246,0.06114977,0.0638259,0.012570741,-0.06105383,0.044564717,-0.039307684,0.0076911193,0.066873565,0.094344914,-0.07517935,0.03488921,-0.014322375,-0.032136254,0.079436496,0.0182244,0.0019705896,0.047224164,0.037133154,-0.038908888,-0.1014763,0.058103535,0.022307001,-0.046495475,0.04019509,0.071082465,-0.02859701,-0.030796906,0.009030916,-0.011430592,-0.007418957,0.016668165,0.061153833,0.06890893,0.002901986,-0.041771527,0.050956067,0.03987582,-0.0011034404,0.029333772,-0.035226468,-0.02189552,0.014522832,0.047822088,0.0025910146,0.045648158,-0.019198554,-0.036172155,0.029862728,0.0707004,-0.07137994,-0.048477344,-0.021116562,-0.011565145,-0.055278145,-0.04676527,0.043259904,0.018151648,-0.028209008,-0.011521947,-0.06935375,-0.012566968,-0.06799901,0.04908437,0.08588889,-0.04750063,-0.037158098,-0.04853173,-0.1014783,0.018512772,-0.02173789,-0.107104726,-0.00819157,0.061715614,-0.021765253,-0.07683786,-0.036610574,0.011572123,-0.013767137,-3.252119e-33,0.09720138,-0.052711267,0.073217355,0.022223216,0.0022385486,-0.04406512,0.057018317,-0.122093014,0.023358675,0.016779883,0.030315502,0.06475083,0.0287237,0.034604512,-0.019671902,0.07467311,-0.042368848,0.09042192,-0.011960079,0.010321227,-0.023451032,0.09102184,-0.008041917,0.037580516,0.100905135,0.0032367862,-0.024882369,-0.0049043735,-0.006021347,-0.03834778,-0.0048844754,-0.02737553,0.0025609946,-0.06757297,-0.03137991,-0.053405464,-0.07100308,0.045947164,-0.019811107,0.03712307,0.019466955,0.041829243,0.024106454,-0.029584346,0.054022867,0.07744504,-0.09691358,0.005017813,-0.07522406,0.03921783,-0.0018912655,0.019164566,-0.0011194262,0.038628343,0.04139727,0.049686953,0.06384248,0.074215,-0.033614896,-0.020629415,-0.073198535,-0.030987786,0.01011021,-0.07915929,0.03357484,0.020605108,-0.028517123,0.009724147,0.015678475,0.0029540362,0.08357058,0.008743154,0.001866011,-0.01688292,-0.05276727,-0.059305687,-0.12875581,-0.051896635,-0.041990265,0.02123317,-0.02568326,0.053678706,-0.021406675,0.009841564,0.009924128,-0.012547075,0.052101374,0.0329239,-0.04684092,0.047502827,0.0016775577,-0.027538875,-0.01909407,0.028107869,0.090529166,-3.9192468e-08,0.054315906,-0.04369779,0.027153661,-0.07341202,-0.07065744,-0.020505598,0.09567291,0.09029892,-0.019438205,-0.008918123,-0.010701186,0.12182007,0.041197747,-0.007364114,0.09233496,-0.03128762,-0.08165539,0.009525379,-0.059901223,0.00570439,-0.046906,-0.022062698,-0.0786893,0.05857891,-0.0010710083,-0.09926136,0.09067769,-0.017856063,-0.012492801,0.031007823,0.04260278,0.058399003,0.0021662356,-0.042690642,-0.009019696,0.037870757,-0.07061503,-0.09755105,-0.0037395575,0.03504852,-0.033255305,-0.05223784,-0.02276468,0.002443369,-0.08736779,0.06592483,-0.02576545,0.056098375,-0.018978238,0.059884466,0.02057377,-0.014301536,-0.09082177,-0.09113353,-0.056369793,0.004455758,-0.009464744,-0.003319405,0.05938131,0.02300177,0.07429195,0.019044172,0.117565766,-0.12749262 +3.1.3.59,Involved in the biosynthesis of thrombocyte activating factor in animal tissues.,384,1.0,-0.066621244,-0.07414653,-0.05116546,0.020231308,-0.0060660774,0.057510775,0.027653381,0.12846704,0.035950005,0.0999558,-0.029107295,-0.011711416,-0.032007482,0.02053172,0.030036394,0.09675544,0.0073058815,0.0116788875,-0.008799316,-0.10785077,0.018693848,-0.0046755397,-0.020509448,-0.054735497,0.023618896,-0.02819348,-0.069522485,-0.0813334,0.025744436,0.022404417,-0.04064346,0.040343937,0.043552358,-0.072594434,0.013140359,0.063425906,-0.03989439,-0.054934792,-0.0037018443,0.009277673,0.13384306,-0.07085289,-0.024431057,-0.04980867,0.040366743,0.029709596,0.034574814,0.10548988,0.009832888,0.06010029,-0.06418548,0.0051437365,-0.030724827,0.0012639677,-0.062767476,0.013212475,-0.035934813,-0.0033880346,0.027911035,-0.016785698,-0.08354744,0.026911585,0.00252715,0.059250142,0.058235373,-0.052920043,0.020845082,0.015278563,-0.071944565,-0.0045896834,0.024216281,-0.043547686,0.015813593,-0.0013436857,-0.0027154319,0.003651141,-0.009069266,0.026937837,-0.015056952,-0.00081359537,0.04550449,0.0028362563,0.07789142,0.074989215,0.017040528,0.019212304,-0.005725581,-0.015616132,-0.030235609,0.054655455,0.042232316,-0.057599112,0.024092725,-0.016219968,-0.002121798,0.007589603,0.0048710895,-0.024324179,0.057884865,-0.0017737759,-0.05221194,0.014609686,-0.012431643,-0.05164314,0.033205103,-0.005788715,-0.05458558,0.108915046,0.024351945,0.06385615,0.023700342,-0.0564308,0.02107081,0.028284369,0.04090444,0.04311868,0.024088964,-0.048024595,-0.008984265,-0.053851455,0.063032925,0.057661057,0.027796632,0.02903204,-0.08091857,-0.0065226615,0.01589634,-5.6984954e-34,0.10870659,0.015465142,0.005729155,-0.09065171,0.005134473,0.026340323,-0.075052924,0.013749877,-0.0072479774,0.10886868,0.018707618,-0.08966293,0.036327463,0.0033200718,0.0006604235,0.012068082,-0.036912456,-0.06448669,0.13052239,-0.017135965,-0.040137894,0.028380834,-0.039928492,0.048002105,-0.11841129,-1.8779781e-05,-0.045055635,0.07746543,-0.038848296,0.006029291,-0.06574683,-0.11913543,0.036166284,-0.04810732,0.005976897,-0.100387946,-0.03272407,-0.09206572,0.027512714,0.03330963,0.06837294,-0.064493,-0.043783497,-0.065051086,0.037761584,-0.0783979,-0.04405853,0.04414348,-0.04045455,0.032119464,0.040658087,0.023447944,0.19286725,-0.05406184,-0.031354763,0.029360084,-0.0012244318,0.015390574,-0.025299093,0.056836065,-0.10367211,-0.0399907,0.0143921,0.035567295,-1.3730167e-05,-0.109970085,-0.01981333,-0.036435183,-0.12842876,-0.003801942,0.093669064,-0.03150966,0.03416049,-0.06256372,0.04448712,0.017943062,-0.020564305,0.085124485,-0.057088863,-0.043561563,-0.0073043657,0.026371364,-0.064733885,0.022481438,0.00917812,-0.008832919,0.06126999,-0.012122037,-0.024198754,-0.06854207,0.033313844,-0.07681415,-0.05630197,0.012848793,0.08154152,-1.0822617e-33,0.0018014408,0.016272163,0.041205153,-0.011368057,0.019810816,0.007236354,0.027908038,-0.025074784,0.023279391,0.06467657,-0.011643637,0.0016255883,-0.056835495,-0.026453704,0.0021077537,0.021914782,-0.009306352,0.048312414,-0.0672626,-0.038472272,-0.005589304,-0.029465076,0.029973231,0.07609691,0.029833715,0.053811226,-0.082687,0.026464747,0.006889862,0.08007911,-0.07670637,0.0264681,-0.046593346,-0.07971319,0.045468207,0.05853094,0.037288416,0.03263621,0.0018870872,-0.05557367,0.018501673,0.03825807,0.022668378,-0.0018725184,0.06201409,0.1110337,0.003166519,-0.0050215977,-0.030614652,-0.011869868,-0.04562125,0.033495247,0.10092526,0.053847224,-0.03787569,0.06475038,0.08250518,0.022179872,0.027831485,-0.04502345,0.04033736,-0.057989348,0.075229526,-0.079081476,0.0375038,-0.013238309,0.0050676363,0.034735724,0.016125249,0.01720762,-0.009450102,0.050310414,-0.035818126,0.005387812,-0.052832942,0.04485386,0.021172106,-0.06891899,-0.041424908,-0.016726134,0.015400717,-0.019721335,-0.025204187,-0.093434796,-0.046441197,0.0056431727,-0.022053361,0.08487737,0.03636458,0.009103486,-0.08542621,-0.021680428,-0.06799029,0.053069815,-0.014210227,-2.339451e-08,-0.02605586,-0.07257588,-0.06393409,-0.065726064,0.045622624,-0.024970565,-0.10478803,0.030513097,0.014492961,-0.017011441,0.008490985,0.006587807,0.009565423,0.03066939,0.080322415,0.053779177,0.08259646,-0.06727853,-0.020131387,-0.09053275,0.031186728,-0.043123145,0.04632766,0.03334565,0.0047530923,-0.11249764,0.004552457,0.011996694,-0.011466677,0.028364232,0.011034563,0.027110117,-0.0369693,-0.028237348,0.014699407,0.020038735,0.028000893,-0.106627926,-0.035679948,-0.04834549,-0.02676438,0.04017539,-0.082419455,0.04449498,-0.0068325335,-0.0027655242,0.040991697,0.02948814,-0.020070298,-0.08943035,-0.09376338,-0.029518576,-0.07577606,-0.061277516,-0.07442019,0.015013008,0.032925967,-0.014777275,0.084215134,0.0032421963,0.004600246,0.07905366,0.17802973,-0.080590956 +3.1.3.60,"Also acts, but more slowly, on a wide range of other monophosphates.",384,1.0,-0.004241288,-0.15355296,0.051950667,0.0054288013,0.032938052,-0.045311447,0.047732342,0.056762118,0.067349195,0.055768557,0.052981302,0.0255714,-0.028744806,0.11653183,0.034722403,-0.021437695,0.004303191,0.0055441014,-0.016340386,0.010277412,0.120278366,-0.006128992,-0.00940905,-0.05385601,-0.014945653,0.06065855,-0.026776236,-0.018858759,0.054782655,-0.09269414,-0.053334236,0.024818722,0.013093515,-0.047546845,0.002813463,0.1528196,-0.043864187,0.00933219,-0.00588508,-0.045699704,0.08979331,-0.06638993,0.040667094,-0.027107561,-0.034114417,0.02239843,0.035301924,-0.045594107,0.018348565,-0.015376989,-0.052526377,-0.081114605,-0.028461467,0.017805278,-0.034168057,-0.008934069,-0.08802157,0.046606027,0.008113194,-0.05694675,-0.0727759,-0.013331717,-0.0012098778,0.06620702,0.117933586,0.024085889,0.052815665,-0.019722896,-0.010083811,0.016994692,0.016451398,0.059733965,-0.003779612,-0.0016756369,0.00049911626,-0.01596831,-0.026676789,-0.045541048,-0.0064145806,-0.018080616,-0.01944554,0.03612753,0.03323857,0.0005020703,0.0012003895,0.047576483,0.015399938,-0.06643609,-0.08915151,0.029708268,0.005786549,0.020160748,0.024265775,-0.012741151,-0.022119517,0.017164797,0.039181307,0.013845211,-0.028622458,-0.008923311,-0.021499831,0.0738985,-0.06419318,-0.037473984,0.0008406877,-0.0072405497,-0.041348975,-0.017142622,-0.03207895,0.08030357,-0.03827789,-0.015515187,0.041763593,0.04942597,-0.032356665,0.058427807,-0.0051555745,0.0066428618,-0.06826983,0.012898028,0.024394445,-0.0627948,-0.049780805,0.046944674,-0.040601544,0.06706189,-0.047158435,-2.4429829e-33,0.045257878,-0.023791026,0.034514513,-0.074032605,-0.031297814,-0.017468182,-0.04868247,-0.003978267,-0.019431533,-0.022644615,-0.00630778,-0.05388944,0.06920028,0.03984139,-0.04257883,-0.07908667,-0.037674922,0.08286958,0.023206888,-0.048999373,0.008816855,0.069684185,-0.058713216,-0.0029729267,-0.032130573,-0.03311504,-0.06727169,0.00039060254,0.019822042,-0.016940529,0.049423985,-0.013249814,-0.11347728,0.047307696,0.06897746,0.013166369,-0.0314613,-0.050324675,-0.008204813,-0.092271686,-0.03697774,-0.0046416596,-0.10351826,0.012468049,0.070432514,-0.07738572,-0.09256387,0.05534189,-0.0274939,0.05695105,0.10738014,-0.040199187,0.087077945,-0.030245444,-0.0023188735,0.033950906,0.027479913,-0.079454094,-0.06335989,0.09443623,0.02117428,0.024235824,-0.036968872,0.015144481,-0.0053587663,0.033385266,-0.116661586,-0.048487205,0.018816052,0.060371015,0.0028694745,-0.019467814,0.05097252,0.0034116139,-0.023577267,-0.023041751,-0.008255298,-0.036870502,-0.004697302,0.058146827,0.035854135,-0.0779233,0.009845055,-0.061531667,-0.054497715,0.009998456,0.051340394,-0.14926977,-0.016927285,0.010216798,0.08516413,-0.083700836,-0.09569504,-0.033528533,-0.027863821,-5.6570427e-34,0.082319185,-0.03243308,0.008310761,0.053981587,-0.06884062,0.05200404,0.028142424,0.011416408,0.029795008,-0.020635327,0.05343829,0.013309181,-0.043223485,-0.0006697634,-0.0055716634,0.052341573,0.08377263,0.10698905,0.059498724,-0.015543279,-0.04577856,0.11345602,0.0585629,0.12776487,0.04407891,-0.0044062836,-0.059822407,0.026780074,-0.063232586,0.032679267,-0.02325293,-0.0072065024,-0.11988767,-0.07042305,-0.039500754,0.010702581,-0.0664323,-0.035539605,0.01899626,-0.055338655,0.010007541,-0.0083527025,0.14515796,0.053989567,0.031122468,0.0316604,0.007834581,0.030263573,-0.10327023,0.029292824,-0.020852052,0.03412611,-0.0151272,0.050298024,0.07148152,0.06516728,0.020376751,-0.045594838,-0.059042923,-0.046253458,0.019150633,-0.021238105,-0.042633656,-0.03838838,0.074182495,-0.00891696,-0.017966557,-0.025545409,0.10659678,-0.024806675,0.09632483,0.047262892,0.0008315826,-0.03138192,-0.052949518,-0.021598943,0.003425974,-0.07083284,-0.04890031,-0.10194882,-0.06165704,0.11887491,0.0056820987,-0.092783146,-0.093416564,-0.007481221,-0.013043401,-0.0012048194,-0.013161539,0.055918876,-0.032528583,0.005921172,0.052776013,0.03929306,0.067640886,-2.4098213e-08,0.040913522,0.030051062,0.07551432,-0.024958704,0.007081593,0.057504393,0.05595858,0.011908786,0.030681552,-0.03532583,0.008526745,0.032926545,0.10144726,0.010406894,0.13663247,-0.018439485,-0.019220414,0.0027346406,-0.0848835,-0.049832433,-0.08120373,-0.039971303,-0.05615028,0.078290366,-0.05314263,-0.028665943,0.03833389,0.05431255,-0.030461254,-0.03903713,0.045120373,-0.033240505,-0.027224472,-0.058502674,-0.035081886,0.059532106,0.027982054,0.0011304292,-0.043217763,0.040118497,-0.065047264,-0.025924465,-0.02773341,0.043402757,-0.05433386,0.025361903,-0.0051397947,-0.01717151,0.027229022,0.018841805,0.08159098,0.025330864,-0.048581053,-0.027779033,-0.036676038,0.02629304,-0.018562708,-0.039665237,0.043346632,0.019517848,0.04854331,-0.0022246111,0.1151908,0.010136343 +3.1.3.62,"This ubiquitous enzyme degrades myo-inositol hexakisphosphate (phytate) to Ins(2,3)P2 and Ins(2)P. Activities have been characterized in the yeast Saccharomyces cerevisiae [2], the plant Lupinus albus [3] and the bacteria Bacillus sp. [4] and Raoultella terrigena [5]. In mammal cells Ins(2,3)P2 and Ins(2)P are the major inositol phosphate compounds found [6]. The mammal enzyme is also active on Ins(1,3,4,5,6)P5 that is dephosphorylated to Ins(1,4,5,6)P4 and Ins(1,4,5)P3, and on 2,3-bisphospho-D-glycerate (cf. EC 3.1.3.80, 2,3-bisphosphoglycerate 3-phosphatase). In addition, it acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3 in vitro (cf. EC 3.1.3.67, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) [7]. It does not hydrolyse phosphates from the 2-positions of inositol phosphates [6]. In other organisms the degradation of phytate follows different routes. (cf. EC 3.1.3.8, 3-phytase, EC 3.1.3.26, 4-phytase, and EC 3.1.3.72, 5-phytase).",384,0.99999994,-0.06747698,-0.08744555,0.024328684,-0.056038704,0.08366789,-0.027224319,0.03093881,0.052488744,0.0684076,0.101326816,0.020432893,0.038901653,-0.06420472,0.058346238,-0.04143023,0.058919486,-0.025139898,0.03490129,0.016939295,-0.006222402,0.13590647,0.020944884,-0.043714583,0.00831728,0.011181497,-0.0032247973,0.07380742,0.03305282,-0.06183617,-0.10780809,-0.067624986,-0.010022732,0.062107198,-0.08010148,0.051272683,0.11784265,-0.025497984,-0.039983567,0.062784635,-0.042200577,0.113539174,-0.0327823,-0.028486775,-0.014981365,-0.06796608,0.0012606378,-0.047823045,0.036956795,0.056406595,-0.043925367,-0.05986047,0.023366507,-0.008042335,0.0328074,-0.08776416,-0.018039027,-0.022477038,0.11297767,-0.020243334,0.009209422,0.013328068,0.0045983093,0.059723932,0.060041815,0.011033513,-0.044938702,0.055876818,0.04227867,-0.06738659,0.0125755565,-0.043215524,-0.004149888,-0.00062741054,0.018145682,0.053436797,0.060759917,0.0031835597,-0.011509296,-0.026214823,-0.05447147,0.038121577,-0.022936977,0.06808063,-0.017591346,0.05974693,-0.029855475,-0.053442955,0.032810017,0.036446653,0.0056411945,0.05342461,-0.014477232,-0.012781677,-0.02176912,0.046342093,0.047176093,0.0026772677,0.030664193,-0.0036065094,-0.047956433,0.03290466,0.03084661,-0.07722961,-0.07714925,0.013184254,0.06073891,-0.049306024,-0.016063275,0.06798049,0.06382275,-0.05614357,-0.02332294,0.032560777,-0.015261863,0.031735484,0.053628996,-0.002503324,0.011694622,-0.013335596,-0.020476827,-0.011270051,-0.006525079,0.03530162,0.072150595,-0.12073271,0.035392143,-0.0501467,2.158992e-33,0.011254069,0.0049018697,-0.03772539,0.0027353487,-0.020229565,-0.052645482,-0.018075695,-0.034245938,-0.16606891,-0.021137107,-0.06219679,-0.061612826,0.04402111,0.005802426,0.00280055,0.05335332,0.044119623,0.032006893,0.11023262,0.018462032,0.028463548,-0.018751424,-0.074542515,0.012484937,0.102909334,0.11096476,-0.032133542,0.002107868,-0.009586304,-0.0349814,0.044811595,-0.08799133,-0.09951939,0.033837758,0.051610168,-0.10248335,-0.05305727,-0.06400246,-0.023503717,-0.01411599,-0.04368478,-0.009651441,0.041453082,-0.031237442,0.028990723,-0.024903841,-0.019130515,0.037841514,0.07359327,0.017409837,0.049556732,-0.032513537,0.113522775,-0.009939494,-0.11020723,-0.017947484,0.03246338,0.0038398465,0.061998054,0.04815285,0.0012404033,0.047760848,-0.038795307,0.020117756,0.018673385,0.006034043,-0.12772536,-0.013831952,0.009706512,0.08970218,-0.058336582,-0.07747417,0.008151422,-0.02399798,0.040626485,-0.037883315,-0.017486537,0.0036289203,-0.08699814,0.06125089,0.015130664,-0.0655369,-0.014177869,-0.00015946697,-0.07736189,-0.009478981,0.025223097,-0.07279817,0.0010632541,-0.009014051,0.09731125,-0.073155046,-0.052640647,0.06324458,-0.020421997,-4.7252246e-33,0.1170568,-0.00042570318,0.13635936,-0.08958151,-0.13966992,0.069462046,0.06103096,-0.03511424,0.034229826,-0.0149838785,0.013233983,-0.053266294,-0.014410073,-0.028444026,-0.027054012,0.05412471,0.0050837127,0.06747685,0.025280714,-0.023810055,0.0070179733,0.1298396,-0.012220093,0.046568345,0.020408122,-0.016114064,0.048222627,0.030185472,0.007380453,0.024881216,-0.018209932,0.044195265,-0.03696823,-0.027940985,-0.044382524,-0.030303644,-0.06922384,-0.07144145,-0.04000591,0.055703398,0.052556638,0.11693587,0.016066423,0.010053336,-0.021881696,0.042604253,-0.034141522,0.06337774,-0.055048615,-0.018122414,-0.034456156,0.044365097,-0.01573419,0.042530436,0.06085018,-0.044353884,0.003009065,0.032624677,-0.038704872,-0.060148638,-0.04042316,-0.08387471,0.042714566,0.009269382,0.060533494,0.06794094,-0.0408258,0.015875958,0.00542321,-0.019744493,-0.0034198994,0.012006797,-0.00012126849,0.004446563,0.0071528484,0.044556227,-0.040081058,-0.018515993,0.011802034,-0.027476734,-0.0432226,-0.04884848,-0.037350714,-0.042952187,-0.011077096,-0.074332274,0.014708561,0.14799212,0.0023833497,0.006521236,0.03126398,0.023371246,0.009597911,0.02909423,0.05835876,-5.410403e-08,0.017666018,-0.012764374,0.0478972,-0.05292381,0.0073530325,-0.05206952,0.030384708,0.0016915961,0.046071813,0.020518465,-0.097903155,0.03012147,0.07230649,-0.052400045,0.098054856,0.031547844,-0.046115737,0.006736153,0.00622217,0.016939478,0.02764759,-0.06600511,-0.16259553,0.053754177,0.060077526,-0.052601025,0.035987534,-0.02308517,0.02317166,0.012189384,-0.042013455,0.003982968,-0.015504884,-0.0637566,-0.03408436,0.043944057,-0.08133962,-0.050274536,-0.06583649,0.036936764,-0.013137358,-0.0697729,-0.037565097,-0.006367989,-0.013823868,0.017980784,0.00836412,-0.005140569,0.025100054,-0.066743046,-0.015090079,0.006155615,-0.066770315,-0.059095643,-0.03395912,0.005189995,-0.012761241,0.013677995,-0.008987255,-0.052571304,0.051125478,-0.0393185,0.104255565,-0.08886889 +3.1.3.64,"This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P2 to Ins-1-P.",384,1.0,-0.043288648,-0.08819846,-0.034333155,0.0035732521,0.07697473,-0.02556936,-0.0650979,-0.004038249,-0.025784563,-0.048301242,0.06499784,0.04836632,-0.060521517,0.08538875,0.05103402,0.088433385,-0.029333094,-0.0038429052,0.023219606,-0.062626176,0.010628812,-0.034566738,0.02027932,0.02563741,0.0494938,0.006960016,0.07649774,0.06672582,0.007852005,-0.09523807,-0.0038209413,-0.023944218,0.005081925,-0.08511572,0.080491014,0.023201222,-0.114189126,-0.026313078,-0.027063083,0.03619612,0.12773997,-0.0110513875,-0.07201013,-0.039252523,-0.02162117,-0.041451074,-0.039349362,0.030651616,0.03395028,0.034370884,-0.022611644,-0.024891924,-0.014434568,0.05231461,-0.030881416,0.01116191,-0.015222764,0.06468876,-0.082666844,0.005268743,0.03767868,0.043697327,-0.05851624,0.03155537,0.02519044,-0.004037388,0.056465533,-0.067863844,0.025594594,0.012886853,-0.0795462,-0.08969598,-0.011316074,-0.025633197,0.028451944,-0.028771458,-0.0012585184,-0.08245941,0.053700853,-0.025044406,0.0072406237,-0.09474698,0.034641545,0.047585953,0.06935363,0.000693136,-0.037038106,-0.010861027,0.009548535,-0.047756694,0.04906524,0.03449414,0.002072496,0.023294069,0.031513546,-0.01035899,0.004992483,0.017444924,-0.0364469,0.0060671447,-0.027354077,0.06890111,-0.092826135,-0.121378794,-0.0690571,0.03470791,-0.03981028,0.0243083,0.053082366,0.051696297,-0.04277374,-0.022544438,0.10270575,0.031448506,-0.04335817,0.11813406,-0.015320664,0.019757524,0.0519874,0.000920174,0.004381939,-0.004480616,0.052711442,0.06706347,-0.039841443,0.09499124,-0.017355524,-8.219757e-34,-0.012177159,-0.0029337066,-0.04048806,0.020423315,0.0020242585,-0.001407971,-0.097029515,0.024660893,-0.09290807,-0.030106863,0.008551927,-0.108517066,0.044391166,0.01827763,-0.026513714,-0.036832772,0.041491568,0.045311272,0.03241365,0.028100356,0.058821525,0.023987502,-0.0722707,0.049581774,0.0073255002,0.05660573,0.010130105,0.087473094,0.026843777,0.008931502,0.037053045,-0.05455855,-0.1397671,0.035567958,-0.04754635,0.0006967511,-0.02311446,-0.061375536,0.0070596775,0.06244739,-0.019473793,0.019345064,0.07352053,-0.1047122,0.030896794,-0.11633717,-0.043097436,0.12641884,0.059190966,0.038128044,0.097543135,0.014766344,0.05454206,0.0065659797,-0.07627096,0.026504101,-0.023406167,0.045779597,0.09499885,-0.06341584,-0.006386797,0.03651462,0.015507808,-0.009424655,-0.003054777,0.09818898,-0.05806476,0.0071075126,-0.04083231,0.072409935,-0.09376331,0.06660478,-0.029028455,0.009548411,0.03448153,-0.047980085,-0.008393408,0.043094672,0.059702896,0.01733116,0.034159437,-0.030469049,0.09556381,0.03585037,-0.0029119735,-0.08883211,-0.0037853078,-0.023324082,-0.055138744,0.04271351,0.1264325,-0.042879853,-0.008922261,0.08284731,0.027059907,-1.5548365e-33,0.04076227,-0.05085158,0.04532958,-0.10837228,-0.06147576,0.032526605,0.05617235,0.013222272,0.077586435,-0.0010243459,0.11975555,0.022412958,-0.013228475,-0.076414,0.02550415,0.057759356,-0.032562,-0.010445971,0.0019227788,0.05873375,0.0777345,0.01829125,-0.02376128,0.05386676,-0.053737033,-0.026035914,0.0021401804,0.0026661598,0.08200855,0.055257514,-0.012515385,-0.017233126,-0.059587322,-0.05691223,-0.0353787,0.025818339,-0.10963663,-0.007692173,-0.04018649,0.056274574,0.0019796721,0.025179159,-0.052613117,0.086996764,0.026067834,0.0639021,-0.00074004306,-0.02350535,-0.008819607,-0.04484173,-0.047591124,0.018694688,0.0152838575,-0.016394263,0.005856312,0.024131345,0.0068303053,-0.09181655,-0.108123384,-0.045483854,-0.06917479,-0.024999525,0.050350107,0.020317312,-0.016050246,0.032086354,-0.05166682,0.061104026,0.041721504,-0.046642352,0.10569948,0.07414458,-0.012211969,0.0073444154,-0.03025183,-0.0211393,-0.047015518,0.011447477,-0.036716867,-0.015137386,0.0066318577,-0.02325783,-0.039173365,-0.07314971,0.017279008,-0.07605843,-0.039441083,0.0979912,0.02221403,0.005756218,-0.024746884,0.0248032,0.0071659116,0.02840954,0.08287586,-3.7960376e-08,0.014506815,-0.050967235,0.10967523,-0.013817399,-0.042085942,0.0063501364,0.007958192,-0.018843478,0.005444318,-0.039602805,-0.10989529,0.09886102,0.008069534,-0.028211923,0.0118537685,-0.03147594,0.025582517,-0.0077339415,-0.02018765,-0.07592944,-0.10187977,-0.03137386,-0.040369924,-0.0170834,-0.0025975665,0.015886297,-0.010863107,-0.03344943,-0.051223896,-0.037355017,-0.026024902,0.026565963,-0.033552963,0.041931372,-0.049563512,0.0295922,0.006406265,-0.0008826928,-0.052205306,0.041885972,0.05467864,-0.040901143,-0.068362355,-0.0080151325,0.027557792,-0.034560494,0.05714872,-0.0769385,-0.03568557,-0.016492402,0.068981126,-0.014169177,-0.10867106,-0.01411508,0.028933587,0.0058180336,-0.049594842,-0.04192214,-0.03393221,-0.065998755,0.031598423,-0.0067381687,0.14257741,-0.052480265 +3.1.3.66,"Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.",384,1.0,-0.07026639,-0.08564899,-0.039303925,0.040020056,0.08819417,-0.059273213,0.02362305,-0.016204502,-0.06085924,-0.014624515,0.06635756,0.045690287,0.034004495,0.011172111,0.063342355,0.05740246,-0.032161236,0.043790426,-0.006172161,-0.043875847,0.048393533,-0.058457598,-4.8034708e-05,0.029132923,0.07198654,0.057475023,0.105986,0.019265661,0.018420124,-0.050206162,0.00702731,-0.048528463,0.027281057,-0.11397632,0.05836454,0.019492831,-0.09486757,-0.00792709,-0.04735554,0.0193797,0.07411447,-0.012805373,0.040969323,-0.06665048,-0.02662859,-0.08638893,0.008235907,-0.02925219,0.0115158735,0.048849672,-0.006316961,-0.022382924,-0.07940735,0.027889868,0.0096812975,-0.009388475,-0.10838609,0.03217451,-0.092451476,0.0030948415,0.039550055,0.053809337,-0.06175454,0.022961553,0.047392253,0.023312466,0.052805457,-0.029305842,0.05525244,-0.045374274,-0.049948677,-0.08138682,-0.052920956,-0.05993233,0.012789148,-0.047258295,0.07176722,-0.07076196,0.06213946,0.018693073,0.007916223,-0.036124814,0.08580244,0.055437855,0.04133042,-0.03477563,-0.015255298,0.042907972,-0.008568052,0.025576953,0.064119734,0.061023243,0.013074482,0.037270587,0.024831021,0.021402927,-0.061417818,0.025363615,-0.003574942,0.021212354,0.007244606,0.07517032,-0.064918555,-0.01958329,-0.04986474,0.04171609,-0.032269534,-0.018851638,0.026231542,0.056035534,0.020649275,-0.014713625,0.06498086,0.059010457,-0.0067859176,0.11614105,-0.053030208,-0.03197066,0.086779125,-0.027135765,0.046057,0.02411504,0.04765621,0.03908766,-0.03893285,0.09062903,-0.027063629,2.0491546e-34,-0.041986533,0.030187521,0.028947655,0.010851591,-0.04483415,0.04270201,-0.08401147,-0.0014157395,-0.08315153,0.009904687,-0.0698156,-0.06307277,0.01537399,0.010189575,-0.0059382473,-0.059740823,0.016594877,0.05590761,0.09401865,0.054225713,0.011933855,0.12757444,-0.030461373,-0.002168726,0.05615872,0.095004804,0.026250001,-0.010941056,0.012555006,0.024394093,0.069467,-0.090652086,-0.107345246,0.032549128,0.00982466,-0.044078182,-0.08135018,-0.063664965,-0.032279115,0.074989125,-0.0969768,-0.041126993,0.03380666,-0.035749815,0.012440111,-0.09468878,-0.07114561,0.07516846,0.043696795,0.066273525,0.08446233,0.023035187,0.04166022,0.040279992,-0.101060726,0.012043145,-0.047634136,0.081209406,0.12880008,-0.030139329,-0.007344167,0.05365435,0.020881077,0.03402061,0.070289135,0.096911564,-0.06442039,-0.06339668,-0.0214949,0.062513165,-0.053796306,-0.0011855218,0.009242904,0.009146141,0.025424594,-0.052786738,-0.023504976,0.027024856,0.04210274,0.037105154,-0.069712736,0.013070807,0.08049341,0.019068813,-0.057014793,-0.056796174,-0.042094305,-0.035246912,-0.008555726,0.017941,0.08430598,-0.0102852555,-0.033847358,0.053981014,0.018237207,-2.117315e-33,0.06664867,-0.024727248,0.057918,-0.110543296,-0.115998164,0.026630344,0.08021671,-0.03991085,0.08259542,0.026218891,0.07344565,0.014802951,-0.012286304,-0.09739798,0.014642181,-0.009039124,-0.05611503,0.009522233,-0.038169418,0.014437036,0.083230115,0.04804019,0.0140489945,0.0203269,-0.030533183,-0.02655423,0.034486625,0.010194387,0.075882226,0.058402456,-0.011675844,0.060988467,-0.03144945,-0.06789415,-0.07522835,0.050988834,-0.08317466,-0.019596614,-0.059776545,0.08324901,-0.021934766,0.06608153,0.039207473,0.09773971,0.050941147,0.07658069,-0.010809561,0.025368838,0.045303572,-0.042477004,-0.05666689,0.012781774,-0.030935155,-0.027251005,0.02900642,-0.03308792,-0.020442093,-0.056407254,-0.04414957,-0.051860083,-0.048045848,-0.060959812,0.099504925,-0.036492728,-0.008394229,0.059614565,-0.02310332,0.0027768272,0.06127881,0.021459335,0.08505274,0.039176445,0.0024309107,-0.009011351,0.0030753394,0.017495805,-0.02487776,-0.01646015,-0.013963282,-0.08809828,0.029079737,-0.011438918,-0.014302626,-0.046859358,-0.04144081,-0.13098986,-0.032699823,0.09332779,0.071371935,-0.019926244,-0.032903988,0.029140124,-0.048942793,0.020714132,0.030978391,-4.1947207e-08,-0.022057148,-0.07494291,0.045932516,-0.021054681,-0.042930476,0.043775737,-0.025022114,-0.07772593,0.058060367,-0.04119419,-0.04127953,-0.000826449,0.0030201573,-0.065899044,0.023120902,-0.009112085,0.022404669,0.025957566,-0.046614993,-0.08794041,-0.040792223,-0.049964245,-0.086150184,0.023163658,-0.00864208,-0.01495991,-0.019563707,-0.022349905,-0.061361372,-0.00036835994,0.02032454,0.02140301,-0.06449272,0.031562604,-0.08549612,0.038973525,0.0068686474,0.0016411825,-0.05048403,-0.04123056,-0.039016526,-0.06752847,-0.015269964,-0.008476549,-0.009507487,-0.039229322,0.03720491,-0.066672325,-0.021068338,-0.0041367374,0.032650363,-0.059301533,-0.08074598,-0.038173895,0.044134445,0.013837538,-0.0023566408,-0.02638558,-0.064604566,-0.07024321,0.02180513,-0.00469535,0.09886748,-0.057856202 +3.1.3.67,"Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3",384,1.0,-0.05853031,-0.091442324,0.00053878024,0.0013075166,0.04668953,-0.09032744,4.98734e-05,-0.0026376648,-0.058367267,0.029465426,0.039800804,0.005039685,-0.010353652,0.051585305,0.038091913,0.07278627,0.028493224,0.047491364,-0.008118869,-0.081452504,0.08090752,-0.0596002,-0.030049592,0.021584231,0.07398598,-0.012044743,0.08334282,0.0072719813,-0.018059539,-0.027095241,-0.042290222,-0.010129156,0.034741648,-0.08830653,0.059585065,0.13498732,-0.08860787,-0.032457,0.0035372805,-0.030013153,0.06820884,0.0016186719,0.007979185,-0.009127148,-0.026122468,-0.09098663,0.023970706,0.014524187,0.08880784,0.032990742,-0.06375142,0.017359188,-0.027153803,0.009989686,-0.057281427,-0.02885216,-0.12408761,0.05467371,-0.06742513,-0.00790615,0.017779915,0.0032202215,-0.07250978,0.029224258,0.029688124,0.024345545,0.04470763,-0.033336915,0.0182414,-0.0039351615,0.009870052,-0.053530205,0.03103836,0.0046313787,-0.031028261,0.0011214538,0.041544303,-0.08271487,0.07609931,-0.0124442605,0.026155239,-0.019689638,0.0971326,0.028674187,0.05239046,0.015976382,0.0020117308,-0.00010205845,-0.017994255,0.044065163,0.10819943,0.0463881,-0.041131534,-0.017934455,0.037518874,0.016914679,-0.04547315,0.020016812,-0.03358763,0.009338023,0.011201779,0.07244103,-0.047278695,-0.034164246,-0.040446542,0.02573112,0.010715778,-0.045003206,0.00041493762,0.042540427,0.042530067,-0.051494543,0.07373856,0.056238614,0.010833329,0.10292064,-0.063385226,-0.085138954,0.03245518,-0.03877717,0.02180459,-0.0019909372,0.011710641,0.044139758,-0.09133051,0.082387425,-0.042311907,3.406139e-33,-0.01506578,0.03944973,0.0306319,0.027267182,-0.060753305,0.05775704,-0.032683596,-0.019354599,-0.0947737,-0.009858588,-0.052160747,-0.10286323,0.019053293,-0.012240108,-0.011482578,-0.07117753,0.015682977,0.055660933,0.13084513,0.06420579,-0.0032312032,0.066267595,-0.068400234,-0.014060786,0.0010720089,0.14503464,-0.017417673,-0.029469343,0.07365511,0.029808506,0.020210411,-0.0757945,-0.09293874,0.061087146,0.006640981,-0.06538626,-0.04060762,-0.048531696,-0.0335813,0.023610411,-0.09274521,0.0008416758,-0.03734051,-0.019414576,0.0069980198,-0.081098974,-0.027316805,0.055645064,0.019210806,0.09795714,0.09694125,0.03199342,0.046342645,-0.013364207,-0.107080825,0.020050237,-0.033379674,0.0203352,0.122098915,0.0013595485,0.014052793,0.034433287,0.032136086,0.004849599,0.08364022,0.03485527,-0.11067032,-0.06254447,-0.013005639,0.07313288,-0.012294976,-0.018287795,0.004853729,0.028632848,0.030133367,-0.0113788685,0.014345627,0.03969173,-0.0012828158,0.023480237,-0.00423882,-0.04184431,0.07073816,0.039196894,-0.023494156,0.006512934,0.03359694,-0.020368306,-0.011087201,0.02504928,0.0909293,-0.03293848,-0.025905004,0.09453365,0.0061315736,-4.180955e-33,0.08568486,-0.040725254,0.07843808,-0.09898207,-0.13461766,0.07374628,0.0821619,-0.08508982,0.12446046,0.04998526,0.117072225,-0.023637114,-0.03029176,-0.07543137,0.0047205323,0.0053059803,-0.030214287,0.015144708,-0.012947882,0.013515505,0.08992001,0.10089603,0.014448498,0.07114163,-0.0016048661,-0.026088146,0.044151004,-0.041904468,0.034751296,0.062355533,-0.025156824,0.07997121,-0.03469028,-0.045577634,-0.07261086,0.0016236757,-0.05889512,-0.0128297545,-0.04826431,0.06236555,-0.027149936,0.08991288,0.022114126,0.0956353,0.021150602,-0.014090463,-0.011598778,0.06323919,0.023023512,-0.042622875,-0.027388142,-0.016690347,-0.045397516,-0.03488647,0.040240232,0.004933169,0.017429462,-0.010921873,-0.04624065,-0.07940857,-0.080365114,-0.079071805,0.091013096,-0.052229885,0.05785188,0.081784956,-0.03950635,0.024684735,0.012028536,0.026223976,0.013515718,0.029173657,-0.0031252336,0.009946896,0.016424583,0.039989464,-0.034142688,-0.015187358,0.049171668,-0.06585032,-0.033271734,0.013168867,-0.036927685,-0.045124978,0.0015462047,-0.13839507,0.007981905,0.10335698,0.041353155,0.024252426,-0.024186723,-0.016526924,-0.019103615,0.025323031,0.031169243,-4.7508237e-08,-0.01299198,-0.052317772,0.028639928,-0.040288065,-0.03995169,0.015316802,0.011307952,-0.07162934,0.063429415,-0.030765897,-0.023973798,0.005319823,-0.0015813577,0.003282041,0.023540407,-0.020188008,-0.008400262,0.033122294,-0.034850404,-0.09916602,-0.041162625,-0.083867155,-0.1017801,0.05032828,0.05206026,-0.030003186,0.0055019744,-0.004797935,-0.03375954,0.0052613607,-0.015293938,0.002255012,-0.06324152,-0.032419495,-0.051851906,0.03182774,-0.01619243,0.034200743,-0.07445722,-0.027436623,-0.08612154,-0.074294105,0.044574775,-0.016941875,-0.030599365,-0.026276931,0.02011867,-0.022011431,-0.013130419,0.042264856,0.031761747,-0.060023896,-0.043927703,-0.058296394,0.027116546,-0.026976263,0.01333834,-0.028777236,-0.046768602,-0.07545329,0.028338477,0.026788108,0.08044075,-0.08193229 +3.1.3.68,Also active towards fructose 1-phosphate,384,0.99999994,-0.030881327,-0.08350539,-0.07890931,0.04708885,0.04635723,-0.013083629,0.0067515424,0.03737875,0.030429786,0.042525243,-0.024748499,0.041729555,-0.0317695,0.051731538,0.014327806,-0.028770378,0.021511609,0.04678961,0.010680823,-0.021253346,0.056956515,-0.043403868,0.028362941,-0.021568762,0.032521304,0.01868965,0.0055623413,-0.031074172,-0.002684718,-0.09247595,-0.05838355,-0.047617167,0.030427627,-0.004836493,-0.02110976,0.076974735,0.022672996,-0.019714542,-0.03549977,-0.015399087,-0.008390275,-0.07238459,0.08679391,-0.03789815,-0.043722574,-0.10756078,-0.040337127,0.023345232,-0.0127326595,0.0024543665,-0.05205967,-0.04082822,-0.0077271326,0.035588153,0.08036328,0.09155097,-0.06714596,0.058209483,-0.028835941,0.04068778,-0.00624443,-0.0405775,0.017867958,2.178233e-05,0.06981054,-0.033376977,-0.019226039,-0.05736803,-0.04774133,-0.0070296647,-0.05795084,-0.034486037,0.015018236,-0.046224415,0.05240777,0.036055706,-0.055791985,0.008822801,0.048715927,0.094426885,0.050742168,-0.020612156,0.0060045277,0.03196044,0.059302747,-0.02473713,-0.0020692488,1.2032962e-05,-0.025132148,-0.020425173,-0.02463318,-0.010101806,0.036553662,0.006589966,-0.05990423,0.037489355,-0.05720842,-0.018108437,-0.02832577,-0.024230905,-0.0129558025,0.07844798,0.0040264907,-0.0028232064,-0.11106945,0.010644811,-0.044403084,0.11005136,-0.008085005,0.017955285,-0.030437158,-0.032697935,0.028456438,0.011989445,-0.10573698,0.013273646,-0.013880261,-0.07236029,-0.011841878,-0.054336008,0.010123085,-0.0058869566,-0.0011485239,0.06478942,-0.047339503,0.005305041,-0.040530693,-3.4926426e-34,0.0746724,0.028007556,0.037820242,-0.05503698,-0.018810393,0.015418503,-0.05628164,-0.003919815,-0.0044566295,-0.0037400958,0.0060456702,0.035722937,0.114593685,-0.029188992,-0.07813259,-0.09591404,-0.04697713,0.0068784035,0.064932205,-0.009938428,0.0504971,0.04715106,-0.0003713629,0.047405075,-0.018810628,0.011772789,-0.044450138,0.04435738,0.001647166,-0.002590108,0.0936911,-0.02686549,-0.1308649,0.002649765,0.03998013,0.008702211,-0.13764857,-0.0029839608,0.011923346,0.06144651,0.026623774,0.015940491,0.031130176,-0.02193104,0.034635037,-0.045968864,-0.06973082,0.10075512,0.016028518,0.062479466,0.020136705,-0.03696975,-0.062259723,0.044829726,-0.036284853,-0.009211124,0.008708223,-0.04098648,-0.028635036,0.012719872,-0.041514825,-0.02398391,-0.03699888,-0.039366093,-0.050968315,-0.0017778267,-0.037188783,-0.0326053,-0.013857285,0.10523201,0.0029890079,0.01617642,0.048241924,-0.006443111,0.02391666,-0.0003341518,0.009795186,-0.011704742,-0.026678285,0.093065985,0.075786136,-0.11142143,0.005639857,-0.03607832,-0.106259465,-0.0377065,-0.082922034,-0.13519004,0.043156,0.034061518,0.0139333485,-0.056085758,-0.015205515,0.009399359,-0.0017358452,-1.0533468e-33,0.11404643,-0.10963082,0.067665935,-0.006032087,-0.002010863,-0.014455221,0.04238072,-0.09786959,0.0836056,-0.03509547,0.084689766,0.009175411,0.007661627,-0.011881569,0.0036736822,0.04524889,0.010169811,0.06910971,0.030875323,0.05943452,-0.058238335,0.11256081,-0.032152265,0.09986239,0.07092603,0.021207003,0.0005290393,-0.011195468,0.04211481,0.060592968,-0.042091522,-0.014638777,-0.04155157,-0.032430578,-0.09342256,-0.023095679,-0.023390388,-0.0053448146,0.037999317,0.07408359,0.048454102,0.07984149,0.041592408,0.0040295115,0.021703199,0.06736101,-0.04340843,0.027250879,-0.027307047,-0.020206641,-0.020358983,0.055892777,-0.06832353,-0.008376412,0.07389439,0.070668094,0.003465285,0.010365093,-0.03505839,-0.043667752,0.00896936,-0.05180226,0.04007313,-0.0633987,0.018602535,0.032022495,-0.022663236,0.07130771,0.021874348,0.0541632,0.083909124,0.020225864,0.090268366,0.04696053,0.027835887,-0.07621802,-0.07526291,-0.041067548,-0.041691393,-0.004868149,-0.0033491733,0.067830384,-0.11746541,-0.114050865,0.068594724,-0.06040289,0.017206993,0.021540565,-0.028988572,0.019296689,-0.11602488,-0.003505543,0.052656807,0.04525978,0.08490907,-1.744422e-08,0.036772754,-0.017215146,-0.012180917,-0.04195081,0.012987602,0.048715394,0.05834482,0.0111847045,-0.01725339,-0.050281856,-0.044809073,0.20282283,0.069622286,-0.022167759,0.094810255,-0.009867415,-0.012255987,-0.039054867,-0.04744594,-0.01725564,-0.049953137,0.024559775,-0.08173069,0.0003680165,0.009759874,-0.033592775,0.045879986,-0.019154735,0.048387226,-0.026429798,0.006327156,0.010208684,0.12339105,-0.07989425,-0.027014032,0.055259775,0.0055494523,0.01429821,-0.10167374,-0.0015948004,0.028213436,0.017615037,-0.024590388,0.017573677,-0.056350447,0.043003775,-0.004122553,0.052560214,-0.101706274,0.017737374,-0.020967359,0.027184565,-0.08996408,-0.032003645,-0.05459689,0.038656343,0.017216278,-0.04255373,0.00078199076,-0.011414512,0.057315465,-0.021580812,0.19875842,-0.04564005 +3.1.3.69,"Acts with EC 2.4.1.213 (glucosylglycerol-phosphate synthase) to form glucosylglycerol, an osmolyte that endows cyanobacteria with resistance to salt.",384,1.0,-0.13017319,-0.011709731,0.017347235,0.027810618,0.0036711607,0.021118386,-0.029431542,0.033533506,0.010161744,-0.025062617,0.075012766,-0.057926554,-0.022688355,0.01751854,-0.05412192,0.009709484,-0.040044483,0.034345347,-0.047912996,0.037007418,0.107556246,0.08304473,-0.025182495,0.00090222945,-0.017227998,0.060537245,0.022795215,0.057945594,-0.004245111,-0.03575504,0.004543395,-0.05117133,0.054073516,-0.049472086,0.08502093,0.020204041,-0.018026637,-0.116845235,0.01823094,0.043824956,0.080991246,-0.021454087,-0.018513046,0.029510556,0.043798354,-0.028884053,0.09752673,-0.033589747,-0.016999025,-0.031719323,0.00014365162,-0.04052897,-0.048453927,-0.038973175,0.011545256,0.050482627,-0.15178189,0.014789492,0.042347416,0.002286841,0.11396434,0.06880526,-0.03192609,0.043668814,-0.014214089,-0.060039207,0.0647549,-0.08372036,0.021513997,-0.009488752,-0.08407889,-0.05233195,0.03354605,0.08452217,-0.011064768,0.009698211,0.0097628385,-0.043703545,0.00747826,-0.012919524,0.044623807,-0.037142772,0.02090369,0.011838867,-0.0039720223,-0.06452227,0.054402556,0.0056331307,-0.04004864,0.011012324,0.044299718,-0.08032619,0.034223728,-0.0045355326,-0.036971204,0.071247086,0.012541609,0.00039373367,0.047665343,-0.0041138357,-0.05948698,0.06818049,0.040928394,-0.07072041,0.121711716,-0.04241478,-0.008547598,0.04850232,0.011521257,0.035160583,0.006383632,-0.009398317,-0.021221984,-0.00089573854,0.0070403456,0.0359346,0.027274655,-0.011193503,-0.08690499,0.055363182,0.031985905,-0.1103072,-0.027863024,0.041286815,-0.021998031,0.10100698,-0.10129332,2.2655545e-33,0.083966635,-0.028055316,0.055086136,-0.031400036,0.024587858,-0.040039174,-0.04762755,-0.0011552459,-0.08031387,-0.0704927,-0.0816691,0.035594758,0.04356552,0.079105385,-0.06541324,0.038986146,-0.055643834,-0.003424768,0.09964683,-0.04022344,0.047717795,0.04086822,0.027707944,-0.02679241,-0.020247707,0.05034578,-0.030753797,-0.07487383,0.122822054,0.002986621,-0.048150107,-0.10782275,-0.057217766,0.0018886303,0.06574855,-0.015713464,-0.021594344,-0.07601922,0.047261946,-0.008049314,-0.06154232,0.0065090866,-0.005401497,-0.020704279,0.08095386,0.01307926,-0.07151049,0.0691395,0.08445328,0.014651352,0.064211674,-0.06379959,0.039488096,0.060128596,-0.013824472,-0.011210259,-0.01913065,0.014276859,-0.023376634,0.04496499,0.006360039,0.11814529,-0.039681647,0.012414538,0.02452737,0.009335048,-0.08462039,-0.0491174,-0.018447494,-0.014790297,-0.036353957,-0.060374405,0.042254366,0.06346225,-0.007328749,-0.043554135,-0.0081379665,0.058450982,-0.021110674,0.04352226,-0.02241591,-0.03306953,0.022680087,-0.008305093,-0.04943203,-0.021229034,-0.042462364,-0.06451028,0.06086853,0.029077876,-0.016996881,-0.01764006,-0.077556536,0.018699972,-0.053270224,-3.831118e-33,0.09974011,-0.02364367,0.021251729,0.0297992,-0.011673457,-0.0019637512,-0.06626434,-0.041938126,0.048340224,0.01680738,0.05903,-0.05522946,0.122874305,-0.020934144,0.0012225026,-0.026399346,-0.02215948,0.049643323,-0.12126303,-0.011304234,0.0012517058,0.045021962,0.012359232,0.06875031,0.041633785,-0.04186046,-0.0122121265,0.014057934,-0.04963597,0.028193815,-0.027589245,0.020592928,-0.06562068,-0.11880647,-0.050420105,0.014135394,-0.047395427,-0.009172417,-0.016181992,-0.024178028,0.04048577,0.0044610985,0.029977422,0.07343375,0.075804584,0.07178666,0.07923765,-0.004941094,-0.012219643,-0.05807494,0.027059585,0.01315061,-0.03688122,0.058220986,0.05173557,0.07854921,0.031562798,0.005714605,-0.03477914,0.0067342883,-0.013287626,-0.12363911,0.07048955,-0.12126509,0.09287245,0.044067644,0.019644734,0.070199914,-0.005435003,0.034719773,0.07730971,-0.022077546,0.016486187,-0.045770247,-0.026281338,0.038720623,-0.085432395,-0.10080614,-0.052252952,-0.07748974,0.046879213,-0.015589078,0.024363657,-0.03891305,-0.036822937,-0.029035822,0.0504439,0.08079185,-0.076754086,0.043859653,-0.047837205,-0.03486266,-0.02578344,0.115890644,0.020659797,-3.183086e-08,0.013134366,0.036991127,0.031844128,-0.03836629,0.018700548,0.08802203,0.05032626,0.048883915,0.057961117,-0.026378708,0.006879203,0.033718415,0.0499555,-0.04098897,0.043780103,0.087143846,-0.0005790921,0.034480736,-0.006326901,-0.009201239,-0.060441203,-0.080011636,-0.081136845,0.04631637,0.0019813457,-0.09514899,0.075049594,0.07631482,-0.025299003,-0.024561912,0.00038698266,-0.022507165,-0.045323677,0.032590862,-0.060922444,-0.0013606,-0.040095367,-0.037294663,-0.009219245,0.032877777,-0.06704946,0.020276368,-0.08197995,0.051168513,-0.016372122,0.047522563,-0.0028751125,0.068093464,-0.051016945,-0.044527188,0.00051673927,-0.04206055,-0.027222967,-0.06610186,-0.08387159,0.056020692,0.0026372925,-0.012431775,-0.04277768,0.016151384,-0.042615388,-0.037851308,0.11572848,0.028325837 +3.1.3.70,Requires Mg2+. The enzyme from Pyrococcus horikoshii is specific for alpha-D-mannosyl-3-phosphoglycerate and forms part of the pathway for the synthesis of mannosylglycerate.,384,1.0,0.0052693356,-0.037223283,-0.021277737,-0.0700053,0.018666752,-0.04041393,-0.007995082,-0.026930867,-0.08669161,0.11237183,0.024829382,-0.035946324,-0.038903337,0.006511903,0.0012349668,-0.05162292,-0.058332738,0.043339156,0.016887909,0.03396867,0.13240506,0.025109587,0.05843527,0.005108568,0.007923742,-0.0211729,0.09019978,-0.022639079,-0.035558205,0.0063793436,-0.038185373,-0.051179066,0.03099607,-0.14803405,0.09457544,0.082240134,-0.05356075,0.031520065,0.029251851,-0.03115164,0.042447276,-0.07515175,0.0733366,-0.0040743193,-0.012374771,-0.04983454,0.04181523,0.020390771,0.062805906,0.041948203,-0.08936692,0.018952385,-0.08123863,-0.01798523,-0.01796999,0.034120064,-0.032236632,0.012890959,-0.009019912,-0.08589225,-0.031893767,-0.0057134703,0.028283155,-0.017248983,0.08670471,-0.044269633,0.038231354,-0.107574545,0.007094112,0.010118066,-0.012309834,-0.040249284,0.0017463852,0.016493713,-0.02601546,0.07504096,0.029767629,-0.07146286,0.024736747,0.001677648,0.05514704,0.0048776567,0.04314647,0.076084465,-0.04110412,0.023171332,0.021619093,-0.002823111,0.012175056,0.07571157,0.06769978,0.01173326,0.031689156,-0.021082528,-0.008298666,0.03573416,-0.07198839,0.0841673,0.0599106,-0.017950743,-0.05473685,0.016318427,-0.0058295955,-0.02049716,-0.070950486,0.017401295,-0.052704085,-0.041372877,0.012290394,0.056136,0.052283067,0.015187335,-0.026204318,-0.004976803,-0.011276599,0.052523956,0.03593212,-0.12518786,-0.058701176,-0.0021182373,0.0010276426,-0.005419534,0.037933134,0.05172587,-0.07784594,-0.031879213,-0.059160523,1.7830209e-33,-0.017523827,0.011757728,0.10316052,0.0011811868,0.009614617,-0.020173267,-0.086405136,-0.09340506,-0.06968096,0.004457297,-0.09843186,-0.08445409,-0.013119094,0.070595756,-0.06703674,0.04593643,0.001214001,0.03002776,0.059925135,-0.023884632,0.014491987,0.0882388,0.009724594,-0.007221526,0.066157736,0.13719417,0.0122515755,-0.039196722,0.043210614,-0.007907636,0.08782798,-0.11494797,-0.033076655,0.008791781,-0.006054735,-0.042991243,-0.048795715,-0.06817746,-0.0022070853,0.012813433,-0.029937493,-0.017857883,-0.017207656,0.017948134,0.048996136,-0.056710314,-0.011807749,0.070993215,0.004436276,0.108289175,0.082896195,-0.0054028267,0.012455551,0.07457747,-0.07159959,-0.022468416,-0.03175339,-0.04435632,0.13058463,0.0456605,0.027374137,0.05295411,0.007548886,0.03814654,0.021240406,0.01572021,-0.009403371,-0.04826727,-0.018691145,0.02548023,-0.040624574,-0.113709375,0.032373816,0.046796326,-0.008813449,-0.028213097,-0.022092098,0.0023239942,-0.02393212,0.0017197939,-0.008420289,-0.008225027,-0.02335612,0.035475966,-0.0702211,0.02191131,-0.06908422,-0.0663803,0.009008936,0.05459515,-0.039367154,-0.022540782,-0.09901452,0.07743108,-0.026421411,-3.63521e-33,0.07355911,-0.050857864,0.062092725,-0.05340562,-0.1136199,0.02916045,0.055196207,-0.06528309,0.078171484,-0.0041688303,0.0579415,-0.0210956,-0.027540123,-0.08026153,0.031452622,-0.040644214,0.035906028,0.07842782,-0.007112989,0.022105688,0.06172806,0.079350844,-0.026763434,-0.013687466,0.057683315,-0.014639445,0.033438355,0.09575252,-0.029940385,0.09126751,-0.040044174,0.07028522,-0.03992692,-0.03752331,-0.04959995,-0.00070908567,-0.048764154,0.024264421,-0.008682326,0.06259719,-0.06310256,0.03956736,0.07839978,0.007840153,-0.015151145,0.052900564,-0.011677701,0.07267785,0.040405165,0.00284166,0.07125857,-0.0021762613,0.0153416395,-0.016933424,0.07743974,0.052805934,-0.036607068,-0.0071493792,0.029613182,-0.044208914,-0.0019269276,-0.07004724,0.072639026,-0.011526394,0.047025044,0.109339684,0.004814838,-0.014374081,-0.0016715311,0.045374893,0.019180248,0.053144995,0.06486554,0.04963613,-0.016222335,0.07430903,-0.0787796,0.003076151,0.09402013,-0.03587699,-0.0011855956,0.06691347,0.009756743,-0.015644714,0.044951677,-0.060979802,0.010913951,0.066791765,0.017217219,0.007220892,-0.041896414,-0.047986835,-0.012599495,0.0121394405,-0.0071508302,-3.2915477e-08,-0.0015441983,-0.059374895,0.030894794,-0.05564967,0.003953123,0.05377525,-0.0099622095,-0.057145096,0.055071373,-0.054379947,0.062097806,0.006922058,0.019303313,-0.0028439283,0.0037960347,-0.03265433,-0.058648296,0.035863906,-0.07586677,-0.07514073,-0.09607646,-0.004766298,-0.11885184,0.0372462,0.04426981,-0.0075913616,0.03236605,-0.012985983,-0.09089888,0.0020087177,0.03401095,-0.0272405,-0.026320418,-0.030329194,-0.065629214,0.011241672,-0.0872835,-0.048188806,-0.050649747,-0.096177675,-0.05562014,-0.013358353,0.0906326,-0.039035123,-0.035745,0.010058716,-0.09168975,0.02350692,-0.059084445,0.04275322,0.044864733,0.015247594,-0.05612547,-0.08834346,-0.079119526,0.0058873203,0.041835766,-0.06711565,-0.05236612,-0.06449786,0.090509176,-0.0056323637,0.08855657,-0.0483566 +3.1.3.71,"Requires Mg2+. The enzyme from Methanococcus jannaschii acts on both stereoisoimers of the substrate and also hydrolyses a number of phosphate monoesters of (S)-2-hydroxycarboxylic acids, including 2-phosphomalate, 2-phospholactate and 2-phosphoglycolate. This enzyme can also hydrolyse phosphate monoesters of (R)-2-hydroxycarboxylic acids such as (S)-2-phospho-3-sulfolactate and (R)-2-phosphomalate, which, presumably, bind to the enzyme in opposite orientations.",384,1.0,-0.09035828,-0.08498211,-0.03382825,-0.00972244,0.05888857,-0.008729425,-0.11171521,-0.009443076,-0.039345797,-0.0030067898,-0.04220288,-0.01649705,-0.016141787,0.030344883,-0.037705228,0.010495288,-0.006961674,0.062161565,0.008927337,0.07257092,0.1271782,0.01927005,-0.04840512,-0.021234512,0.054938342,0.031171076,0.07546628,-0.016676277,0.0048240433,-0.01332954,0.032730464,0.013400693,0.060909323,-0.10228309,0.04626459,0.12083402,-0.017445676,-0.029545896,0.08359001,-0.01117882,0.05608272,0.006246089,0.13860135,-0.043118667,-0.0034758714,-0.079168215,0.013849728,-0.00021468483,0.10436966,-0.03753421,-0.12912911,-0.057359,-0.101243615,-0.0182692,-0.017651968,0.014653799,-0.072463885,0.007573661,-0.012265029,0.01806644,0.020996815,0.007253983,0.003984702,0.030681506,0.031966347,-0.05939057,0.012549925,-0.051992036,0.088932395,-0.011620468,-0.0029027872,0.01690156,-0.015739728,0.009172241,-0.017589457,0.01933518,0.015692286,-0.011652266,0.0670037,-0.0468665,-0.032081313,-0.011720237,0.036170885,0.04328757,0.004730427,-0.015048406,-0.0014683781,0.0011093151,0.04458218,0.033139817,0.05853808,-0.0017595728,-0.044220228,-0.03247576,-0.027654126,-0.08869052,-0.022880435,0.055595342,-0.004263542,0.022457154,-0.013429586,0.015764289,0.010123905,-0.0018762776,-0.037301164,0.011130751,-0.06261981,-0.012755133,-0.020479213,0.08951971,0.091096774,0.017006129,0.058336765,0.0104645975,-0.032533053,0.032410104,-0.048612814,-0.102992505,-0.07931852,0.023402406,-0.031826552,-0.062066004,0.08389326,-0.029662957,-0.023388948,0.023066344,-0.04412441,4.673895e-33,0.0041673193,-0.0060039395,0.059384007,-0.06315664,0.006083292,-0.023039035,-0.09137984,0.022801418,-0.014390997,0.033281606,-0.04207581,0.016112981,-0.010806575,0.040375456,-0.07571178,-0.0031054472,0.045610137,-0.012481961,0.016031351,0.033764742,-0.036421936,0.02599409,-0.013410551,-0.03344275,0.010825443,0.031247681,0.03458403,-0.030736495,0.035212036,0.020906458,0.10755749,-0.110549144,-0.050044723,0.064601555,0.038744893,0.022002824,-0.057746246,-0.09049555,-0.008771432,0.0017231264,-0.037490502,-0.0076460396,-0.017811602,-0.0104462085,0.024692966,-0.013730478,-0.0035001698,0.08845763,0.026743257,0.03300388,0.048330855,-0.024183163,0.019422937,0.058674436,-0.062360752,-0.038679987,-0.04010478,-0.024919068,0.08880331,0.059701934,-0.035821613,0.012181614,-0.006433904,0.03470949,0.022513557,0.0026611425,-0.06699794,-0.0586451,0.021618616,0.07676537,-0.009604246,-0.038062256,0.012725694,0.056296214,-0.028100895,-0.04640482,0.044967853,0.03527437,0.060508568,0.04363859,0.068089396,0.020193683,0.03369819,-0.02273797,-0.1075603,0.05704049,-0.018969016,-0.044515032,-0.026116172,0.055598367,0.042258795,-0.06508306,-0.036539026,0.0801094,0.042799454,-6.621628e-33,0.08360039,-0.07576339,0.04544757,-0.07284331,-0.06875066,0.050852776,0.07531194,-0.026653264,0.04788676,-0.037872344,0.088902935,0.010478698,0.012950107,-0.031190353,0.026282916,-0.022308618,0.06418235,0.11417215,-0.0057295095,-0.029938018,0.020858832,0.12960137,0.011667965,-0.023125244,0.06150941,-0.05205535,-0.015444669,0.064944655,-0.052025482,0.12162024,0.031063413,0.058350462,-0.11146792,-0.10013903,-0.09515749,0.03651105,-0.10794722,-0.02095701,0.016495023,0.04959522,0.022475889,0.06505089,0.045406308,0.03512919,0.02720905,0.034092586,-0.083231986,0.04808894,0.016957305,-0.101276375,-0.019817758,-0.009620815,-0.023787586,-0.018247783,0.0004988049,0.08945141,-0.020350385,0.020134166,0.033978004,-0.03100845,-0.04095447,-0.081049696,0.036178228,-0.0916194,0.0032787449,0.09313896,0.06721198,-0.013801072,0.07177127,0.011536338,0.024698183,0.0741381,0.037440274,0.034018625,-0.06338533,0.05078937,-0.11630955,0.0046398193,0.034439087,-0.07040429,0.050280504,-0.0059593306,0.016259294,0.0027830787,-0.008962187,-0.08699529,0.021617346,0.0535297,0.03294438,0.016364675,-0.035959247,-0.056737874,-0.0790334,0.022763675,0.03392752,-4.9795464e-08,-0.014517971,-0.09089824,0.03750154,-0.06821805,-0.05386589,0.05943262,0.045216825,-0.053393036,0.05851538,-0.03446372,0.0076127015,0.050165173,-0.083246484,-0.019996641,-0.0053877435,0.01599467,-0.08817466,0.054199092,-0.059863463,0.005995814,-0.010881382,-0.06918234,-0.09923337,0.07063886,-0.020729138,-0.046832275,0.04686468,0.07120017,-0.048835937,0.019645028,0.015843818,0.007115369,-0.021195317,-0.027578956,-0.11816438,-0.034105018,-0.084420964,-0.008866994,-0.04838527,-0.07069713,0.02385622,-0.0059365826,0.00044907862,0.008154279,-0.024133872,0.0040523494,-0.0073412135,0.06609898,-0.079852276,0.0044538295,0.05417128,-0.0050904457,-0.042633004,-0.021643981,-0.03910456,-0.04984311,0.030755756,-0.06632527,-0.094986096,0.002317231,0.008348364,-0.0022143675,0.14862427,-0.06323458 +3.1.3.72,"The enzyme attacks the product of the above reaction more slowly to yield Ins(1,2,3)P3.",384,1.0,-0.049576204,-0.07407388,-0.04082354,0.0017642586,0.12643552,-0.031934794,0.020913996,0.06181712,0.07611298,0.04444395,0.055056866,0.002041782,-0.044983562,0.010273874,0.039730504,0.022598732,-0.06436551,-0.02130913,0.0050706146,-0.026340773,0.02535644,-0.041184247,0.020839807,0.005713414,-0.009406818,0.067647725,0.11519925,0.043988243,0.033652253,-0.08127596,-0.033137944,-0.06467987,0.03525739,-0.103476025,0.04814289,0.016558181,-0.13811605,-0.06400675,-0.05870592,0.039268203,0.1273374,-0.008252238,-0.025158979,-0.039825313,-0.057341564,-0.041154664,-0.06729924,0.05401074,0.05938733,-0.0523205,-0.02727307,-0.001997432,-0.069522634,-0.011011192,-0.015465756,-0.049690146,-0.049936567,0.08310848,-0.069283135,0.030466696,0.022015706,0.049092382,-0.010211716,0.009531221,0.103042446,-0.054060947,0.07064322,-0.018983299,-0.0010287177,0.0549084,-0.046064235,-0.016646491,-0.08504037,-0.07900326,0.038998503,-0.03649023,0.0057773683,-0.05655546,-0.0009899766,-0.057897992,0.0103737,-0.07348509,0.027133064,0.08177899,0.03977021,-0.030096361,-0.035433363,-0.014744507,0.015096682,0.01609821,0.037655134,0.015168325,-0.046808794,0.04731832,0.013850406,0.0685323,-0.03135887,-0.018883087,-0.010501327,0.011891428,0.025809992,0.070210375,-0.08258791,-0.061098315,-0.090576686,0.04813877,-0.05311606,0.00057269976,0.018928979,0.10850435,-0.01183073,-0.098498456,0.040303227,0.014512083,-0.08158359,0.13511087,0.022336476,0.0036763742,0.041804727,-0.006222964,0.06493922,0.028156536,0.019864917,0.06324283,-0.1054323,0.0233085,-0.040086024,-2.5492612e-33,-0.00075470255,0.024058962,-0.038589295,-0.047215536,-0.03799425,0.014941514,-0.048777424,-0.012800792,-0.1026453,0.013031621,-0.0944478,-0.15167457,0.10611887,-0.014676481,-0.021210507,0.012284757,0.015349099,0.07103607,0.02116545,0.067121,0.05422996,-0.041199457,-0.031812564,0.03736812,0.02433716,0.052955426,0.012037135,0.0716065,-0.013344212,-0.020541642,0.053864755,-0.050510142,-0.067416206,-0.02208357,0.040750004,-0.008364219,-0.017372373,-0.055675145,-0.010076224,0.07573483,-0.046685923,-0.027634677,0.067456365,-0.045440312,0.06529173,-0.045871656,-0.06296427,0.074335836,0.049966786,0.03785593,0.080778174,-0.018457916,0.07182995,0.06306945,-0.027035015,0.041084304,-0.023109317,0.07058068,0.06919191,0.0037573439,0.0017895098,0.022055365,-0.015572127,0.050044876,-0.021646429,0.07612993,-0.066342786,0.03961903,0.033999067,0.075855516,-0.10453353,0.0013588258,0.012199733,-0.08086814,0.05483502,0.005936209,-0.06765612,0.07330515,0.039393738,0.007079572,-0.02694802,-0.041071948,0.07927216,0.020416068,-0.11526625,-0.059208117,-0.053538628,-8.8869536e-05,0.015030052,0.07094116,0.11645398,-0.0483635,-0.025042119,0.06124241,-0.050696686,7.1000887e-34,0.045291748,-0.03511666,0.056717604,-0.13331458,-0.06038653,0.028525084,0.01056395,-0.019394966,0.058563307,0.05312023,0.055883486,-0.014421926,-0.029914932,-0.07575236,0.03881702,0.031949855,0.012500364,0.051070753,0.032254297,-0.0018303569,0.08344103,0.05643926,-0.015800307,0.024652835,-0.087727115,0.027092453,0.021100704,-0.019514594,0.054631643,0.084729135,-0.029847318,-0.03755003,-0.035685547,0.023488712,-0.038450364,0.0562893,-0.017968059,-0.0032649455,-0.030497976,0.039648924,0.0015078424,0.037388325,0.03848975,0.06276059,0.031510595,0.037932344,0.024153564,-0.010264005,-0.02952697,-0.020737434,0.0031626364,0.031196352,0.0018750574,0.043358263,0.011340256,-0.055497974,-0.014057587,-0.042837374,-0.020588243,0.022219215,-0.044875193,-0.022380799,0.081712246,-0.02473491,0.0035184994,0.023130713,-0.07828028,0.08359198,0.10828196,-0.036481194,0.0425521,0.080183886,-0.0025084354,-0.027202232,-0.06029269,-0.040223025,-0.08033757,-0.008579332,0.0067717372,-0.04383912,-0.021328399,-0.023099752,-0.06461517,-0.029834373,-0.042534422,-0.086031914,0.047739983,0.101512775,0.04625157,-0.011407978,-0.012318544,0.075624816,0.04354796,0.053999707,0.08027531,-2.4403855e-08,0.021267967,-0.05003251,0.046518315,-0.0039652074,-0.013295669,0.012517052,-0.0018557276,0.032771796,0.0035305726,-0.03469037,-0.035247516,0.077741064,0.05626446,-0.05252286,0.08848281,-0.0055834786,-0.02542267,-0.008425905,-0.019982819,-0.10720754,-0.050843634,-0.011995465,-0.078912124,-0.04084745,0.011167204,-0.020395314,-0.012210077,-0.042334817,-0.015059517,-0.02843063,-0.025509678,-0.010962889,-0.006356323,0.04455343,-0.052517302,0.08803515,0.013084305,-0.06119666,-0.0020368602,-0.0092855105,-0.04466872,-0.06339821,-0.04859717,-0.016221631,-0.012454006,0.00023617534,-0.03306612,-0.064851694,-0.01950148,-0.04126761,-0.023878235,-0.032492213,-0.037298974,0.0077104364,0.03594926,0.008686145,-0.057016894,-0.04765227,-0.015773745,-0.026386714,0.036934324,-0.0192733,0.15179235,0.010205046 +3.1.3.73,"This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [3].It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [1].",384,1.0,-0.0042383503,-0.028756429,-0.13116518,0.0018908159,0.0090688905,0.028963784,-0.015180705,-0.018879572,0.032632075,-0.006039961,-0.058246695,-0.05435887,0.015239379,-0.006119781,-0.023170989,0.029178334,-0.03473529,-0.041099437,-0.026302401,-0.060396273,-0.024500636,-0.009710097,-0.002130814,0.031805467,-0.015958596,-0.00022789059,0.079025246,0.03126009,-0.014056892,-0.03462607,-0.056649264,-0.01627653,0.097912766,-0.010134281,0.0498383,0.11510224,0.032253932,0.002612534,0.03692881,-0.010992918,0.031682488,0.029589089,0.011994148,0.030408699,-0.020573556,-0.0051668417,0.026738783,0.036462743,0.044121284,0.0006989427,-0.063794784,-0.056109294,-0.07223845,0.0019102658,0.039738953,0.051774174,-0.08522122,-0.06713612,0.026750231,-0.013394721,0.061140087,-0.07474912,0.02804785,0.052400976,0.037146356,-0.059192125,0.076422796,-0.05599634,0.012508943,-0.047557645,-0.019465622,-0.07837335,-0.051047664,-0.00072925945,-0.063906506,0.038501155,0.0660768,-0.054309867,0.020963114,-0.02149053,-0.033610176,0.048329532,0.057336744,0.05241262,0.07073094,-0.020625573,0.01712967,-0.0077419076,0.0812549,0.0707925,-0.03770001,-0.026697356,0.08550921,-0.050830536,-0.077139735,-0.03620537,0.062275052,0.0302933,0.026656605,-0.026725883,0.007281352,0.10478373,-0.04504118,-0.047285013,0.008993983,-0.065197855,0.027205944,0.1807509,0.004018769,0.048989695,-0.02168663,0.064118266,0.059272394,0.022853207,-0.018282436,0.11392951,0.011107872,-0.052142326,-0.112450905,0.103795126,0.012109506,-0.05520504,-0.015759423,0.017708465,-0.036150906,-0.03404563,0.011336017,3.7290354e-33,0.052124456,0.0020794063,0.016939327,0.0064371834,0.028525548,-0.013585407,-0.082275786,-0.009282444,-0.034214627,-0.015121293,-0.028444761,-0.06730848,0.056389663,0.039954603,-0.08488925,-0.052742537,-0.032559052,-0.010141595,-0.0035229132,0.08437836,-0.002986254,0.030715331,0.024733633,0.007897974,0.022768158,0.062222864,-0.020592162,0.062361,0.038074154,-0.005853533,0.013372042,-0.03736785,-0.1361697,-0.027361171,0.023257257,-0.0412137,-0.028502567,-0.006574757,0.0011864717,0.08451229,-0.044690337,0.039669115,-0.07608329,-0.031064546,0.028091663,-0.08258452,0.01317982,0.10305743,0.037654586,0.08779731,0.0064702975,0.0260297,0.109397456,-0.04373702,-0.04818276,0.019590648,0.007237946,-0.020646932,-0.012271319,0.048525155,0.022193898,0.039773572,-0.03981258,0.08745824,-0.005966885,-0.024936203,-0.015921894,-0.054042,0.024959456,0.053977925,-0.050639875,-0.057773393,-0.004720134,0.057730094,-0.046030775,-0.040315025,-0.07072799,-0.10773656,0.049724072,-0.084574185,-0.016838705,-0.020181967,0.033067156,-0.025083968,-0.045161214,0.027051661,-0.027497562,-0.03504517,-0.051753983,-0.023380874,0.013013097,-0.022487044,-0.041959506,0.0075295586,0.020010736,-4.63747e-33,0.12895489,-0.089689374,0.048037145,-0.1561619,-0.077272676,0.053265125,-0.015128496,-0.055971988,0.07132634,-0.002608439,0.06877581,0.01834434,0.01841133,0.008848072,-0.03528319,-0.034089457,0.05588338,0.08227257,-0.06451125,-0.066037714,0.008054904,0.014697098,0.005596185,-0.034542475,-0.025257476,0.077917755,-0.0026794507,0.09861685,0.02259252,0.08246109,-0.036945127,0.029569948,-0.020582628,-0.04095075,0.01636885,0.07132721,0.013867103,0.0016846816,0.00558733,-0.007514375,0.01354635,0.06859422,-0.026456196,0.061219268,0.029453114,0.06958409,-0.07576326,0.068369344,-0.004460512,-0.036861926,0.024782272,0.0026563366,-0.02627782,0.046342853,0.07191612,0.046768043,-0.013201226,-0.054840975,0.030631863,-0.116936855,-0.06581377,-0.012501515,0.056055233,-0.052082106,0.040873844,0.012715685,-0.011254376,0.012174553,0.018521594,0.06305679,0.019816995,0.08829394,-0.027295941,0.012971861,-0.0995345,-0.014141876,-0.020303553,-0.07874701,-0.017264556,-0.04063579,-0.050166164,-0.03258106,0.04799615,-0.03383796,-0.025456596,-0.062096965,0.056891263,0.048700884,-0.026014494,0.022767892,-0.042210493,-0.0746869,-0.02161389,0.020274129,0.013596522,-3.544475e-08,0.020419681,-0.09982527,-0.009041905,-0.020346152,0.0150965,0.11166388,-0.07251551,-0.046021245,0.09186408,-0.05319124,0.0204443,0.10593213,0.08270353,0.020714896,-0.06020176,0.034356914,0.0033986112,-0.044920877,-0.0021078961,-0.045892652,-0.091455765,-0.028734308,-0.0149786845,0.022922082,0.063012,-0.037874013,-0.0071756477,0.055718243,-0.04397942,-0.0113701215,-0.06329105,0.0027863916,0.059470795,-0.0135564795,-0.026222827,0.0089331735,-0.002451012,0.010364286,0.001182322,-0.04287915,0.035357773,-0.0055349707,-0.11600233,0.02372821,-0.0018158382,0.034904502,-0.028384792,0.07559506,-0.06727339,-0.07337533,0.07285681,-0.032312036,-0.009675218,0.010330094,-0.031924088,0.061874375,-0.048321012,-0.08829725,-0.0053060353,0.0071422546,-0.029255258,0.03178774,0.12755664,-0.16492727 +3.1.3.74,"Requires Mg2+. This enzyme is specific for phosphorylated vitamin B6 compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate. This reaction can also be carried out by EC 3.1.3.1 (alkaline phosphatase) and EC 3.1.3.2 (acid phosphatase), but these enzymes have very broad substrate specificities.",384,1.0,-0.047325745,-0.091159165,-0.047468692,-0.09093984,0.059030503,0.0177438,-0.010735924,-0.0056448365,-0.028923795,0.044645905,0.008287514,0.01575666,-0.038012736,0.005668077,0.01669399,0.05744991,-0.031388532,0.061236292,-0.009066142,0.029025018,0.10388558,0.00069985405,-0.0006837535,0.040386267,0.027753124,0.017695418,0.1059401,0.016841631,-0.0013174342,0.024867546,-0.06509871,-0.0023627204,0.041381933,-0.07900251,0.021017257,0.12469841,-0.05305788,-0.020507019,-0.091152325,-0.052562106,0.028322296,-0.007578356,0.008481108,-0.04188132,0.0497395,-0.07344396,0.07956016,0.017445384,0.048229724,0.0032351422,-0.07678153,0.010471755,-0.05051195,-0.020849334,-0.009799837,-0.023201795,-0.10709095,0.02201053,0.00041696275,0.036964897,-0.08209085,-0.052409574,0.054913167,-0.0032947569,0.109411664,0.024066316,0.044529952,-0.05362071,-0.031089906,-0.064506434,-0.04050637,-0.052170698,0.029997379,-0.015081404,-0.034689937,0.103319615,-0.028392013,-0.048364118,-0.016152121,-0.0004744673,0.010870193,-0.053020567,0.018283796,0.13663732,0.04435809,0.0007920128,-0.011373866,0.019621706,-0.028817488,0.08978013,0.06338926,0.021885611,0.0106091285,0.010886571,-0.009494078,0.064168766,-0.0776144,0.04113164,0.05172768,-0.0631518,-0.061715875,0.056121018,-0.04743333,0.032003365,-0.033599447,-0.0063446024,-0.013812071,0.04174643,0.00025133093,0.01733238,0.072616406,0.046905596,-0.03827713,0.02068748,0.04841029,0.051354706,-0.011411238,-0.08670052,-0.08441191,0.03018377,0.022801973,0.025431344,0.030519934,0.0050680474,-0.06788876,-0.014473719,-0.050915264,6.816745e-33,-0.011451856,0.09805242,0.037000455,-0.00888609,-0.03336063,0.058193117,-0.077695586,-0.0041280715,-0.079440795,-0.0669566,-0.022334743,-0.03714153,0.03876083,0.0123304,-0.010092955,-0.066187926,0.04222199,0.0011814084,0.13067953,-0.004390529,0.06436465,0.014402105,-0.005688435,0.016410127,-0.011640957,0.13622284,0.034027044,0.012700305,0.023341324,-0.02073982,0.02604803,-0.10538238,-0.05453693,-0.017168315,0.024533136,-0.0585908,-0.11040946,-0.024993144,-0.07531729,0.04068365,-0.030940937,-0.033647906,-0.10531158,0.081246704,0.04677099,-0.083840325,-0.021673614,0.050471023,0.030325025,0.038893916,0.030789165,0.015643606,0.047862727,-0.0046947985,-0.061116494,-0.02574259,-0.055280015,-0.053187538,0.010601793,0.03498087,0.069480896,0.02396018,-0.007823523,0.043345574,0.0054221167,-0.016203271,-0.06727761,-0.068329744,-0.032203186,0.020314956,0.06354375,-0.01840898,0.060887307,0.021231769,-0.012928231,-0.02752821,-0.019912308,0.046651255,-0.008970848,-0.02067529,0.005598387,-0.0430421,0.027938843,0.049431108,-0.081831664,0.02036076,-0.028045444,-0.031936467,0.047215752,-0.034719273,0.06666283,-0.08968635,-0.0249551,0.036208384,-0.042494215,-6.9808165e-33,0.088892706,-0.045332693,0.11258774,-0.06354688,-0.031695135,0.049125724,0.13953455,-0.08668914,0.10587474,0.0030153743,0.008559257,-0.047462344,0.008100903,-0.06951559,-0.023390796,0.014724274,0.007190981,0.06619705,0.033686154,-0.05399757,0.0232483,0.05860656,0.0037928186,0.07277492,0.06591828,0.03115718,0.038220163,0.008490374,-0.0043882034,0.05877398,-0.020982804,0.097759366,-0.0449758,-0.027102461,-0.040794957,0.0631411,-0.08767868,-0.014771784,-0.017062688,0.07653184,-0.028799914,0.034701694,0.035559285,-0.018375518,0.00874248,0.034961455,0.010279001,0.095439956,0.008758491,-0.026921177,0.043079305,0.06257385,-0.05564518,0.025907919,0.058597162,0.02744616,-0.026362406,-0.015391091,0.02489487,-0.06557216,0.010100666,-0.11992224,0.029054234,0.047291387,0.0048764525,0.08771817,0.07849811,0.015443285,-0.013261542,0.049245186,0.061061416,-0.00027412284,0.05010991,0.035169978,-0.045382485,0.042119816,-0.047917657,-0.00972334,0.055388104,-0.060226303,0.019316558,-0.001913271,-0.0018796335,0.0059020836,0.003378966,-0.11364567,0.039855734,0.025045952,-0.014009175,-0.0073570576,-0.051561218,-0.06797632,-0.06517386,0.024343712,0.031016564,-4.7649138e-08,0.04956357,-0.08329284,0.0014699469,-0.064783014,0.05105061,-0.020386523,-0.011549239,-0.021548875,0.09165197,-0.014017139,-0.012729239,-0.05429857,0.0051055164,-0.024716875,0.041129377,-0.009116014,-0.0050745043,0.060814332,-0.028449237,-0.062527776,-0.035743468,-0.02718789,-0.13288808,0.008484449,0.038907472,-0.03337874,-0.07249409,-0.0030360715,0.028731825,-0.016762067,0.05334472,-0.02968895,0.009872052,-0.076317035,-0.048882376,0.047024857,-0.039859544,0.0048163105,-0.07685507,-0.0036188827,-0.08985332,-0.12841612,0.034775972,-0.0039261,-0.027419893,0.03133436,-0.06371202,0.020038642,-0.047049247,0.07098475,0.07248864,-0.04667761,-0.00207692,-0.065795265,-0.084237546,0.019112488,0.05488151,-0.10504199,-0.0386813,-0.08547835,0.025231112,0.03434429,0.102643795,-0.08712809 +3.1.3.75,"Requires active site Mg2+ but also works, to a lesser extent, with Co2+ and Mn2+. The enzyme is highly specific for phosphoethanolamine and phosphocholine.",384,1.0,-0.051137127,-0.08011225,-0.046902053,0.0016633117,0.05417342,-0.034702256,-0.0074250167,0.021730253,-0.057982482,0.02487889,0.026983665,-0.015373906,0.0028794138,0.06948034,0.08730982,0.07008523,0.029022781,0.05006882,0.052646082,-0.0076304995,0.091419995,-0.0073603555,0.0030343719,-0.010892616,-0.019124776,0.035105757,0.022449702,-0.0075844903,0.052964017,-0.016992707,-0.035341896,0.020155208,0.048307575,-0.06812788,0.021296423,0.11127643,-0.07011056,-0.0076638875,-0.055223476,-0.008652702,0.035643335,-0.010226848,0.090922385,-0.050562598,-0.0020054604,-0.078743905,0.048937965,-0.027416445,0.009180908,0.05366817,-0.053930145,-0.04381095,-0.058946148,0.051504888,-0.054411747,0.07236751,-0.14070795,0.048433553,-0.005823207,-0.020992732,-0.015746854,0.0108501725,0.009207446,0.004738557,0.09091399,0.014665625,0.00669575,-0.08696525,0.056202512,-0.014670569,0.01043013,-0.075433314,-0.017482702,-0.0144097,-0.014805328,0.037128873,0.038167037,-0.042034235,0.077244066,-0.008576654,-0.032930028,-0.047465127,0.08476531,0.06809407,0.055637408,0.093468994,-0.0069177416,0.0068162973,0.041131493,0.057464406,0.060878206,0.04474524,-0.009024001,0.008828172,-0.012992574,-0.017387688,-0.027843708,0.074443825,-0.05607594,0.032406636,0.028656464,0.049456764,-0.070074104,-0.037385214,-0.029730195,-0.020111157,0.040352862,-0.01101849,0.012882355,0.03161411,0.0406443,0.02006676,0.060425833,0.029118085,0.026604146,0.083782695,0.020156352,-0.13093019,0.0018552955,-0.005500607,0.040911097,-0.051173124,-0.0046331002,0.041737817,-0.03594201,0.06133843,-0.03355988,4.2402197e-33,0.021977887,0.021992508,0.074379325,-0.025444692,-0.07122303,0.0770234,-0.07588447,-0.03727989,-0.01501879,-0.07202747,-0.07756926,-0.0132059585,0.052464064,0.101324104,-0.0007303684,-0.07695081,0.022443956,0.0047552707,0.14932363,0.005587131,0.037769247,0.0023791185,-0.03509599,0.04267542,9.149061e-06,0.13150853,0.029559799,0.016277637,0.0053411573,0.004468622,0.0413964,-0.13572101,-0.076760784,0.03398148,-0.04738471,0.023633614,-0.07930762,-0.05609951,-0.044213496,-0.01013319,-0.058719486,0.029155564,-0.053483322,0.020898964,0.06449491,-0.11403655,-0.08786539,0.055193696,-0.0050202697,0.07887255,0.007216875,0.014661533,0.037981994,0.017669752,-0.06456249,0.02924604,-0.056037933,0.006201753,0.057121135,0.008254881,0.013851334,0.022748807,0.01634792,0.02786006,0.06680899,0.053184967,-0.033867903,-0.10803473,-0.04212625,0.03433742,-0.021844346,-0.023759488,0.05443067,0.045485996,-0.017682128,-0.08020875,0.009707838,0.007058876,0.01406055,0.037764065,0.054034382,-0.068822995,0.023421695,0.046469815,-0.050761778,-0.057934467,0.013841341,-0.063625894,-0.041791055,0.00097566453,0.034434136,-0.05470222,-0.04377328,0.053624056,-0.0020005833,-4.6390785e-33,0.025445206,-0.0455864,0.07176748,-0.05871605,-0.107757196,0.051461395,0.059395865,-0.17191929,0.09928229,0.00202481,0.0685551,-0.018066386,-0.0008784867,-0.05653284,0.009754934,0.0023553765,-0.046897616,0.0060934317,0.03527462,0.0032609275,0.0040681525,0.12301293,-0.019424468,0.07854547,0.06450779,-0.023491208,-0.0042530657,0.017440796,-0.014619742,0.041841686,-0.01906087,0.070325814,-0.047223672,-0.07464505,-0.075162634,0.039036885,-0.038895227,-0.015882535,-0.029451834,0.011283951,0.006980176,0.016428629,0.00424696,0.019229898,-0.0469055,0.074503936,-0.027155472,0.034281995,-0.016523713,0.0055560526,-0.016710283,-0.0006670083,-0.10149555,-0.06634354,0.051022064,0.02134518,-0.041641947,-0.005467923,-0.073812455,-0.06911508,-0.028764732,-0.047522534,-0.0013733022,-0.012471806,0.0142355,0.06575471,0.03096454,0.039574426,-0.007115277,0.040043313,0.053870387,0.08402099,0.109937586,0.019865394,-0.01232115,0.01003423,0.0012005164,-0.0015831512,0.02851726,-0.15916377,-0.0011860791,0.04459558,0.025922455,-0.063598976,0.044321615,-0.06749938,-0.049465526,0.054592602,-0.0049042944,0.018935258,-0.05935588,-0.08000843,-0.03392717,0.013466166,0.05266123,-3.5412494e-08,-0.011082432,-0.021550372,0.040435776,-0.11561286,-0.038979977,0.07146248,0.036158707,-0.095626205,0.025169289,-0.023579275,-0.0077979323,0.028459797,0.012011979,-0.012788856,0.064312935,-0.007914537,0.006568014,0.05739028,-0.07125734,-0.060820363,-0.041263852,-0.054512247,-0.10683198,0.062344395,0.069840826,-0.019828254,0.037515152,0.05951068,-0.02617004,0.02554081,0.023339689,-0.004389717,0.015783343,-0.051442325,-0.012012276,0.045640066,-0.020103263,0.010005396,-0.0934254,-0.015235287,-0.107237935,-0.055918325,0.044597503,-0.03480678,-0.0072920634,-0.037881024,0.015550355,-0.011320033,0.02518025,-0.00468766,0.021212623,-0.05915409,-0.021495707,-0.08442704,-0.03839082,0.0004274213,0.036976784,-0.06223114,-0.027273139,-0.08817199,0.063577175,0.0147775905,0.09836354,-0.08471162 +3.1.4.1,Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides. A 3'-phosphate terminus on the substrate inhibits hydrolysis.,384,1.0,-0.016342936,-0.08984096,0.008928128,-0.09416122,-0.016548904,-0.01821661,-0.0314831,0.022911238,0.007424434,0.028770566,-0.01273915,0.030638149,-0.08735052,0.06303928,-0.080422394,0.069608755,-0.05490027,0.056747004,0.051318914,0.016428133,0.09004671,0.007925518,-0.041937742,0.04883204,-0.0012162147,0.0784039,0.062410887,0.015107721,-0.02603396,-0.029273627,-0.014746093,-0.060994294,0.049612213,-0.04473423,0.048830174,0.17033139,-0.012737763,-0.009103118,0.019527148,0.058482964,0.054455318,-0.004278486,0.014516449,-0.015772259,-0.04923266,-0.024594383,-0.04703935,0.013778412,-0.033827677,0.0638317,0.035183843,-0.024698887,-0.04097384,-0.05123372,-0.030895924,0.044398893,-0.022349536,0.04585837,-0.035556298,0.0023861364,-0.018298466,0.035394322,-0.0017096424,0.03385172,0.08896141,-0.05994249,0.076836884,0.0098384805,-0.034565113,-0.021983633,-0.012523825,-0.046783984,-0.016220674,-0.00097319786,-0.09011515,-0.046746723,-0.0053993477,-0.0798501,0.023854245,-0.039656166,-0.0205857,-0.09067567,0.0028136857,0.07418345,0.006381874,0.009631597,-0.044627257,0.0017322442,-0.0086317975,0.051344912,-0.0029883275,-0.014426362,0.03863284,0.004883502,-0.013532159,0.029414201,0.04224483,0.052779473,-0.019374326,-0.038692445,0.0046604867,0.10487921,-0.069491334,-0.069248244,0.048359673,0.05966261,0.009546078,0.036752615,-0.013143701,0.020746315,-0.06976078,0.039500553,-0.035673097,-0.003539817,-0.072565764,0.039873697,0.019165838,-0.046506364,-0.0277607,0.005384432,0.0047148494,-0.05557834,0.08311191,0.054631554,-0.048433416,0.012688598,0.008666423,1.5893936e-33,0.035068076,-0.098762535,0.015758647,-0.01336188,-0.024219628,0.047384873,-0.061291724,0.0136203505,-0.065171115,-0.022280402,-0.028485652,-0.010826483,0.09857589,0.026357817,-0.0077426946,-0.040788993,0.02281238,-0.018995853,0.013618697,0.0102519,0.05627763,0.02262968,-0.042767722,0.058286615,0.002987582,-0.020604908,-0.044582326,0.0076644984,0.095541045,-0.009404459,0.0055308095,-0.100701846,-0.05950432,0.050111163,0.089256905,0.005170986,-0.05326772,-0.058240853,0.04393395,0.10196133,-0.04943781,-0.06545569,0.018860856,-0.115471125,0.054767303,0.03609892,0.018064993,0.03359323,-0.071438245,-0.00091274054,0.103272445,-0.03833922,0.021840433,-0.023916027,-0.010224431,-0.08518863,-0.01537257,-0.019207487,-0.014389336,0.05705303,0.0072093215,0.044578508,-0.024827313,-0.029930865,-0.010889634,-0.058795806,-0.015206121,-0.04929578,0.032841377,0.03686744,-0.05290194,-0.038839802,0.11883376,0.009760913,-0.034686185,0.013370447,-0.0056240726,0.043619554,-0.025596073,0.09968289,0.014859373,-0.030019289,0.033830505,-0.018823158,0.015002709,0.038383715,0.04206313,-0.08547854,-0.023678528,0.051167812,0.04152483,-0.045218784,-0.08051326,-0.022531051,0.07099801,-5.1487512e-33,0.069740064,-0.07889877,0.015781559,-0.06373563,-0.11695881,0.018674714,0.05202796,-0.060413554,0.053274482,-0.066578,0.025406266,0.026103644,-0.026869241,-0.08571104,-0.0083766775,0.0017149287,-0.010783763,0.041900057,-0.032109756,0.005857368,0.05097335,0.08542542,-0.014301464,0.04140833,0.049828056,-0.066932775,-0.036882933,-0.0056433273,0.0001943769,0.07054424,-0.05309414,0.015289848,0.029302048,-0.020598404,-0.021238253,0.06935198,-0.14675343,0.0018403833,0.002388055,-0.049312856,-0.022211121,0.07690906,0.03230415,0.04754854,-0.013673511,0.12547964,-0.061527748,-0.022061205,-0.028091226,0.016373785,0.021711994,-0.03392329,0.0136980815,0.09296817,0.08012393,-0.034691498,-0.062283594,-0.029247783,0.024650708,-0.024354815,-0.011985384,-0.044724483,-0.012271675,-0.022506982,-0.01683087,0.06634138,-0.0598525,0.076377876,0.042062704,-0.05638475,0.018702596,-0.014288192,0.049271286,0.012597237,-0.022000195,-0.0062517263,-0.14723079,-0.05036854,-0.055051282,-0.06674815,-0.02949413,0.06993057,-0.06252665,-0.07480075,0.04922718,-0.09311742,0.033310026,0.086181015,-0.08378318,0.016575148,0.03164517,-0.0050800936,-0.011239424,0.05897776,0.04083543,-3.0226094e-08,-0.005740935,-0.03250099,0.07726285,-0.08142057,0.006701844,0.07036728,0.053518716,0.07995654,0.05764878,-0.0027394544,0.022393102,0.03049762,-0.047231402,-0.03558051,0.10952965,0.019800691,-0.067452356,-0.014786338,-0.029230637,0.0009462656,-0.09733967,0.034785964,-0.14126316,0.06809082,-0.056487896,0.03800624,0.067667976,-0.033976264,0.041641906,-0.038276203,0.039883025,0.03968266,0.03315358,-0.09030848,-0.0074361153,0.058985997,0.0014669545,0.01669216,-0.043512546,0.008303599,-0.029315148,-0.07307579,-0.0042123273,0.014467239,-0.00044152822,-0.00090703554,-0.043330953,0.08630523,-0.024060404,0.047345936,0.0847832,-0.01367119,-0.017131802,-0.04103243,-0.057658564,0.005619304,-0.014449489,-0.113851376,-0.07243921,-0.008295079,0.014777134,-0.035589997,0.19241625,0.00050932856 +3.1.4.2,Also acts on sn-glycero-3-phosphoethanolamine.,384,1.0,0.0026373358,-0.06469156,-0.08349326,0.019461488,0.048213705,0.032837853,0.04577049,0.04081143,0.0057707885,0.012511598,0.011150806,0.01591465,-0.03506814,0.10156529,-0.045181166,0.025476187,-0.003609569,-0.014217097,0.011980103,0.004017459,0.08447817,0.011033919,0.018266851,0.052164398,-0.018446635,0.043320067,-0.003793525,0.0026053716,0.0021414277,-0.020259434,-0.007568612,-0.0073778164,0.036136232,0.026748376,-0.016819023,0.059293047,-0.08806866,0.028478686,-0.01394746,0.07661326,0.08194101,-0.06348399,-0.020144604,-0.07169395,0.04000303,0.034450248,-0.013498897,-0.0094269635,0.028987598,0.06161113,0.019081805,-0.10817258,-0.027215555,0.043325905,-0.042014673,0.024097458,-0.13871036,0.075704105,-0.0021382289,-0.011331439,-0.058582988,0.00025157645,0.053534873,0.059456855,0.087797455,0.009782179,0.03204971,-0.09300018,-0.00855434,0.018537674,0.08435135,-0.06273255,0.055104904,-0.06707385,-0.030729996,0.056649372,-0.012060427,0.00050549855,0.000812449,-0.061566625,-0.0068647205,0.016583843,0.054436915,0.08855473,-0.013803817,0.017279208,-0.051308874,-0.0825784,-0.045770887,0.05389051,-0.009070305,-0.05141257,0.014291352,-0.007019073,-0.026053492,-0.035014953,-0.016478026,-0.031756464,-0.0452029,0.0043215426,-0.02983786,0.054562673,-0.04886029,-0.050164465,0.014997146,0.07613894,-0.03709733,-0.07471127,-0.004318248,0.027260227,-0.027255159,0.05959853,0.048344735,0.014484179,-0.02221358,0.09047875,-0.008655446,0.010674708,-0.010482876,-0.012370593,0.017630907,-0.11103572,-0.003401753,0.019933805,-0.052733596,0.07571709,-0.022219688,1.8109491e-33,0.04532249,0.019142682,0.014884131,-0.030924365,0.03756933,0.019406088,-0.045575403,-0.019120663,0.00791143,-0.04774383,-0.05858779,0.00934455,0.051427215,0.08244145,-0.03292213,-0.014387718,-0.016598443,0.017778756,0.06484516,-0.10932452,0.039757714,-0.007694918,-0.038869124,-0.0043785376,-0.06524734,0.069255576,-0.021051923,0.043225124,0.010378317,-0.015409875,0.039214384,-0.046296243,-0.0030536933,-0.0009845933,-0.025016367,0.07455807,-0.03480293,-0.037211437,-0.006192779,0.053109832,0.013278518,-0.018506281,-0.04298888,-0.009972733,0.04496151,-0.03643728,-0.12889397,0.0045165257,0.057142835,0.031210894,0.0025519442,-0.097181104,0.11473114,-0.021280568,-0.032097053,0.014923231,-0.010874228,-0.04934662,-0.024304373,0.016024547,0.029719183,0.052747402,-0.025893822,-0.055514213,0.038411733,0.036996976,-0.065382235,-0.056878656,-0.087424144,-0.070142254,-0.03915416,0.04973779,0.13094087,0.026669795,-0.045865882,-0.04332733,0.014985978,0.041969344,-0.048529457,0.015723307,0.0153491665,-0.07483745,0.055354472,0.014985615,-0.027811684,-0.015506683,0.0059101963,-0.14810558,-0.07825589,0.01868613,0.04511072,-0.08503412,-0.041347563,0.023073273,-0.055530608,-2.3504695e-33,-0.0017181671,-0.06004069,0.07998107,0.019729195,-0.0077059623,0.070348665,-0.00012622624,0.04160457,0.026641686,0.0002161717,0.041541982,-0.038585562,0.0084344335,-0.05262019,0.0072695445,0.05155391,0.03471118,0.051308732,-0.015953071,-0.032737933,-0.008723021,0.07979635,-0.023443108,0.087214746,0.07589069,0.0065352404,0.02355577,0.011488347,-0.049910385,0.08099097,0.012894806,-0.0031178358,-0.12541357,-0.085864894,-0.018668538,0.0001351012,-0.020866375,-0.0045929505,-0.051646005,-0.109130956,0.05734167,-0.0097106565,0.11313345,0.0770388,0.067126065,0.10676926,-0.05782951,-0.019139636,-0.0522983,0.030676564,0.014256463,-0.024454089,-0.04846309,0.07840911,0.11801949,0.07905104,-0.0042015277,-0.03437456,-0.076053634,-0.0654212,-0.0034208864,-0.01993326,-0.039440684,0.013331866,0.06944598,0.06376017,-0.044678513,0.016224569,0.12010523,-0.0072423303,0.0824031,-0.009717102,0.012593325,0.041051008,-0.09020156,-0.032116216,-0.05420079,-0.03140705,0.01815652,-0.10721175,0.011405134,-0.027587622,0.038728986,-0.025964418,0.002494068,-0.011315581,0.0028749115,0.11252434,-0.015843555,-0.009558691,-0.020140013,0.0074079027,-0.079144575,-0.027163602,0.035731837,-2.659661e-08,0.07220333,-0.09959746,0.065726,-0.07526047,-0.017124664,0.010928327,0.14401422,0.037949998,-0.034759637,-0.13171251,-0.012108223,0.05028065,0.0837877,-0.098099135,0.10193481,-0.019627307,0.016423406,0.0992617,-0.042846143,-0.047969196,-0.08315969,-0.05813148,0.012189537,0.038513135,0.024619684,-0.02789451,0.022422157,0.10288474,0.0037654173,-0.0006634662,0.059873033,-0.06255262,-0.02125767,-0.016635887,-0.008113356,0.03836936,0.0067660264,-0.008768718,0.010938282,0.022226725,-0.083775155,0.0035517537,0.015654184,0.058638424,-0.0070757573,-0.028003896,0.050205685,0.012251085,0.019571984,-0.027588135,-0.004500717,-0.016210753,-0.036909107,-0.049068615,-0.11941335,-0.07184241,0.04188618,-0.04374367,0.03207128,-0.038698096,0.0305292,-0.006872425,0.1040661,0.045125645 +3.1.4.3,"The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol.",384,1.0,-0.12283598,-0.014130161,-0.084439754,-0.016984621,0.016095033,0.007944505,-0.00303364,0.042979095,-0.011375322,-0.0017837017,-0.006943974,0.010955587,-0.006178643,0.13359995,-0.017368412,-0.012525179,-0.023388721,-0.0065840245,0.017830193,0.021504521,0.06976187,0.053905904,-0.02732228,-0.041358337,0.0050986977,-0.05268451,0.015088494,0.04519366,-0.04475,0.03982012,-0.03726012,0.034166545,0.020304903,-0.047988255,0.06896705,0.031513922,-0.0063763326,-0.010347729,0.058568303,0.0076582073,0.1071974,0.049284093,-0.021051744,-0.050858296,-0.0006599033,0.07876832,0.050851524,0.04355072,0.008222582,-0.0061334367,-0.14151008,-0.07174434,0.038361244,0.042132728,-0.03957567,0.052314293,-0.09774897,-0.0004987423,-0.01695606,-0.039070334,-0.10951299,-0.030824374,0.0020391108,0.0801245,0.09406665,-0.029588709,-0.05813905,-0.049774665,-0.038763624,0.0023345533,0.013898183,-0.05087456,0.01633424,0.10635878,-0.0070557543,0.037365835,0.030419378,-0.06298064,-0.015145412,-0.08415905,-0.02043392,-0.05526225,-0.01076108,0.093243256,0.043413904,0.027337562,-0.016237983,0.031059412,-0.06602178,0.057633754,0.030478444,-0.05267649,0.052073758,-0.022955887,-0.07326771,0.033227026,-0.04841437,-0.01837462,-0.0096491305,-0.0019401666,-0.036826488,0.03443409,0.053199105,-0.07484955,-0.027974343,0.06437658,0.034603458,0.056421943,-0.05671226,0.08310217,0.030972619,-0.01579426,0.07398218,-0.04725971,0.020558272,-0.0028790038,0.03410307,-0.0015443442,-0.10287968,-0.051005866,-0.022797396,-0.08293849,-0.032092247,0.019020379,-0.06966759,0.0946242,-0.031010795,2.1336185e-33,0.0155625,-0.04031358,0.03545529,-0.07080211,0.018828038,0.05926773,0.055473708,-0.0013974204,0.008441409,-0.035657458,-0.021894129,-0.04904444,0.05288197,0.028416328,-0.082795635,-0.0066575645,0.047584135,-0.027916502,0.03608395,0.10517788,0.11806657,0.024569055,-0.033154704,-0.031297013,0.049355544,0.00399626,-0.08599154,-0.020944957,-0.03776347,-0.018165935,0.027812121,-0.032451175,-0.09570519,-0.040383942,0.13041027,0.00086138427,-0.016303336,-0.047620542,-0.02275627,-0.063483395,-0.045636907,-0.032700583,-0.12697725,0.06545214,-0.0057397755,-0.014723293,-0.07331092,0.054406285,0.025505323,0.009424366,0.08613793,0.010716578,0.07513981,-0.05645032,-0.06651462,0.069292285,0.0047624065,-0.0005047408,0.010796382,0.013907339,0.004286014,0.053829957,-0.060671102,0.07393666,0.0016022109,-0.0022881848,-0.06053757,-0.099609114,-0.06969566,0.070345104,-0.0625751,0.014881792,0.05180919,-0.0067167087,-0.013452513,-0.058303043,-0.05727452,-0.04473593,0.04247756,-0.030906554,0.020830397,-0.11569512,0.02007649,0.01827309,-0.06295077,0.0072485316,0.03457326,0.02442218,0.008196704,-0.06257596,0.104471184,-0.09774821,-0.048663862,0.042517703,-0.033677068,-4.0110395e-33,0.018506289,-0.050982814,0.087385416,-0.039780773,-0.030105243,0.068602346,0.06975443,-0.052902672,0.0038183252,0.005185166,0.108221896,0.022235053,0.0043673534,0.0063790428,0.021374036,0.06707625,-0.058496222,0.05001465,0.031117667,-0.039128445,-0.045672093,0.11223998,0.020809915,0.07137223,0.0054983404,0.00051898137,-0.047706258,0.10345608,-0.031083807,0.08853262,-0.007537503,0.09485192,-0.03556004,-0.13111177,-0.016840514,0.042934485,-0.052464373,-0.02571404,0.004643658,-0.08658494,-0.007913648,0.006421977,0.004424515,0.08442802,0.06558964,0.111056566,-0.04565465,0.082390286,-0.063362285,0.0120240515,-0.038275346,0.056578297,0.01643593,0.02878395,0.05443328,0.017321141,0.026980948,0.0026123968,-0.010509477,-0.07521166,-0.04580294,-0.07426769,-0.0075473944,0.09136378,0.050622858,0.010143025,0.033136718,0.05790696,0.07546232,-0.036257796,0.05384241,0.08018749,0.044882957,-0.022264963,-0.050379705,0.047782067,-0.058222193,-0.04865728,-0.02379628,0.045056522,0.043388594,0.024004795,-0.002972456,0.033669885,0.035520077,-0.01692502,-0.010289377,0.0196569,-0.07856679,0.024254467,-0.09263482,-0.025928142,-0.005012463,-0.017816639,0.017067851,-3.2570913e-08,0.04542488,-0.013050749,0.05420415,-0.08577836,-0.013713421,-0.08953847,-0.008629402,-0.06725773,0.07246012,-0.029756207,-0.023280807,0.017170688,0.03883734,0.024746189,0.094063155,0.019318461,0.0041056243,-0.024211608,-0.04216231,-0.0056221653,0.022491682,0.009361502,-0.10514305,0.100523256,0.0070415046,0.015608218,0.033432133,0.010357339,-0.03445149,-0.0404628,0.014495234,-0.0038117156,0.01597577,0.040898927,-0.048634704,-0.00021573233,-0.056669496,-0.047955014,-0.041488443,0.0314186,-0.039603714,-0.0641858,0.0022310112,-0.03364241,-0.042963397,-0.003875989,-0.005347385,-0.008567039,0.02169644,0.006286305,-0.0032590614,-0.014244649,-0.06304174,-0.0409755,-0.016275462,-0.027195053,-0.009271837,-0.045672283,-0.0124109695,-0.006676518,0.006111932,0.038829487,0.14589402,-0.06494687 +3.1.4.4,Also acts on other phosphatidyl esters.,384,0.99999994,-0.06528654,-0.10764193,-0.031103473,0.01077806,0.048284274,0.0070235087,0.019085431,0.020390287,0.09243766,3.603718e-05,0.05214331,0.03345951,-0.0848405,0.048494242,0.013874397,0.028343815,-0.07390773,0.020812282,-0.00692333,-0.041049022,0.09651873,0.043862075,-0.011058039,0.038993154,-0.05598353,-0.011472498,0.04081623,0.027209042,0.031520564,-0.11472569,0.006592367,0.0027099228,-0.033563267,-0.06662884,-0.017212851,0.06792485,-0.046395328,-0.021810997,0.05236923,-0.010250403,0.12393058,-0.05467828,-0.023875097,-0.058212098,-0.008785443,0.010316174,-0.02930149,0.00768876,0.07961473,-0.015079838,-0.059507024,-0.073189266,-0.04198613,0.030102529,-0.1032742,0.06202133,-0.1362958,0.025816934,0.03005591,0.012690771,-0.09937614,0.020546589,0.0028320556,0.07934994,-0.05273867,0.017311681,0.012998008,-0.036592305,-0.03322726,0.024767622,-0.008505895,-0.073282644,0.022420146,0.054701976,0.017182259,0.047335465,0.0018293606,-0.066925645,-0.024723804,0.0024610371,-0.0528286,-0.023721518,-0.021592066,0.06989515,0.04565791,0.0072909775,-0.026469393,-0.09747682,-0.03861647,0.08165347,0.034808926,-0.054543607,0.017119655,0.0315766,0.018768176,0.0007742625,0.02213586,-0.012809459,-0.00034229358,-0.022729995,-0.09094226,0.017063785,-0.017933216,-0.07756976,-0.089790694,0.0013177281,0.0024493395,-0.04628582,-0.0010088094,0.01813688,-0.01566772,0.005748673,0.06384567,-0.05991086,-0.070291914,0.05260494,0.0039817775,-0.057004232,-0.030389171,-0.070760176,-0.00377226,-0.09030588,0.0055655236,0.019012926,-0.061200563,0.0057926574,-0.055578746,2.2780075e-34,0.0035411743,-0.021463651,0.0046114023,0.025140805,0.010174491,-0.006493746,-0.070400015,-0.02852979,-0.0040914253,-0.075703695,-0.038830508,-0.039046656,0.005924926,0.047514185,-0.033137307,-0.028653754,0.03116964,0.09407468,0.024734274,-0.042377666,-0.010759396,0.07781958,-0.05992552,0.026566016,-0.015627112,0.05230033,-0.070199445,-0.044785265,0.0019639647,0.001161287,0.06630542,0.0060139005,-0.069704026,0.055608917,0.013717713,0.1252567,-0.055518687,-0.050454915,-0.011170715,0.009773576,-0.009487406,-0.007096593,-0.078590855,0.021835387,-0.0020347654,-0.0294869,-0.09864884,0.085544065,0.09012547,0.016207429,0.04295427,-0.048957188,0.074698135,0.04057548,-0.0008111164,0.052932482,-0.055837058,-0.083392814,0.013073437,0.050732978,-0.004406352,0.07741479,-0.039989933,-0.0043969755,0.0073872996,0.037876133,-0.05940555,-0.041818913,-0.06841193,0.058300965,0.016987529,0.032572936,0.118069045,0.04662214,0.0456586,-0.012192063,-0.0025165386,0.009996121,0.035392914,0.08821171,0.06298091,-0.08223089,0.038335092,0.0026523466,-0.026375772,0.020959761,-0.020457266,-0.029292611,0.05879841,0.05888057,0.08080371,-0.111615054,-0.06416495,0.06508992,-0.07481521,-2.7409755e-33,0.019337019,-0.09754627,0.041229457,-0.00012093371,-0.041731995,0.07160446,0.056030784,0.037501488,0.032492466,-0.0018732881,0.05195195,-0.042657826,-0.033900794,-0.06340506,-0.034280423,0.059377808,0.042891342,0.07660491,-0.0048151514,0.009499048,-0.056265183,0.10240836,0.053012177,0.07521497,0.07747876,0.01806715,-0.08507508,0.08007403,-0.079047434,0.06696291,-0.0037599986,-0.01038179,-0.087137684,-0.09744197,-0.014083378,0.0496595,-0.06033777,0.0032938083,-0.009201536,-0.064267814,0.010187389,-0.050457716,0.14964555,0.038505122,0.058092777,0.029809712,0.005025208,-0.026682936,-0.083240524,0.016918674,-0.03597489,0.09402207,-0.034888018,0.05308539,0.017187975,0.09434381,-0.011861827,-0.037866436,-0.018849328,-0.050011482,0.000686835,-0.046515074,-0.040006727,-0.008504845,0.050126877,-0.007284568,-0.029303893,-0.027772408,0.07223431,-0.014969666,0.09844998,-0.033341628,-0.016465252,0.011745377,-0.03223658,-0.0425108,-0.047855396,-0.09215391,-0.028745903,-0.002233534,-0.05934491,0.012181936,0.0038008445,-0.07911407,-0.03354426,-0.003900023,-0.028591422,-0.00062773045,-0.021335043,0.039389852,-0.043829124,-0.0040630237,-0.022246266,0.067171305,0.04438135,-2.0939108e-08,0.031655047,-0.0445845,0.0870751,-0.056795903,-0.022143263,-0.058079336,0.05467921,0.01937334,-0.021837508,-0.020622008,-0.026484502,0.07529553,0.062535204,0.011186816,0.118359,-0.009090071,-0.029597202,0.035087433,-0.046982042,-0.078998424,-0.07226905,-0.00587528,-0.01883256,0.031655405,-0.009045309,-0.024112897,0.07610277,0.042514786,-0.019359156,0.02234659,0.055918604,0.008577167,-0.015715415,-0.03048495,-0.005042489,0.055133007,0.017351765,-0.026269414,-0.04887042,0.086620316,-0.05700712,-0.037158854,0.016437607,0.06326737,-0.0017180996,0.034646787,0.021753578,-0.0024619817,0.03383582,0.013180688,0.07379772,-0.0050057187,-0.026016997,-0.014371423,-0.10745496,-0.049321666,0.027981425,-0.016015748,0.062516436,0.003546219,0.020302141,0.020076185,0.21247809,0.023494678 +3.1.4.11,"These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found.",384,1.0,-0.08975427,-0.052068576,-0.040179394,-0.03620206,0.03444554,0.02654158,0.033786673,-0.018214235,0.08769521,0.07086934,0.047626227,0.022160055,0.0049795434,0.04936368,0.027434157,-0.008953394,-0.080838196,0.026333313,-0.049988694,-0.093565024,0.03250978,-0.01253089,-0.01413555,0.061895482,-0.031907823,-0.02613803,0.064765014,-0.008801919,-0.018709775,-0.036764845,-0.08381972,-0.06740615,0.03309849,-0.057549626,0.007328031,0.07024019,-0.06830722,-0.07654599,-0.08157801,-0.007724928,0.104889855,-0.07775845,-0.006186921,0.019496227,-0.04767984,-0.014147766,-0.0057022087,-0.007701545,0.1087257,-0.040868185,-0.053108033,-0.06802799,-0.0069762473,0.01173219,-0.08853374,0.05603195,-0.10071434,0.07930224,0.037369132,0.060613707,0.005888773,0.03040919,0.016146518,0.0520868,-0.053269453,0.0005323521,-0.003024626,-0.015804881,0.012895077,-0.02308593,-0.032181945,-0.059069145,0.0069031445,-0.0042759664,-0.04585987,0.02529375,-0.001905338,0.0025473738,0.0034222,-0.1032414,0.0658696,-0.028314466,0.055428322,0.05453438,-0.0043883915,0.009497058,-0.032174543,0.040947314,0.026112717,0.0034274634,0.08776737,0.019345777,0.04163897,0.0127520505,0.010705171,0.033477057,0.012712162,-0.024150023,0.07747631,-0.014404076,0.04573959,0.042660356,-0.030386332,0.011193152,-0.01894624,0.015235791,-0.01907018,-0.01636107,-0.017006375,0.044164147,0.059502333,-0.012783122,0.058825914,0.018769927,-0.001785921,0.063016504,-0.03932279,-0.015739635,0.01331327,-0.010305846,-0.0049444214,-0.09181478,0.021747135,0.008015461,-0.040343735,0.061790314,-0.10167909,2.0184177e-33,0.061455283,0.09309919,0.051570337,-0.0025883645,-0.03329469,-0.0046094814,-0.0028694826,0.017751532,-0.041647837,-0.04141666,-0.026015727,-0.061174814,-0.008973628,0.049759097,-0.040574774,0.011035479,-0.02692575,0.0181427,0.087231144,0.022851136,0.012648349,-0.00251419,-0.011394457,-0.035417095,0.040860638,0.08488045,-0.09783371,-0.031999327,0.0029929113,0.02433058,0.048613634,-0.08506532,-0.081556685,0.03829763,0.046838596,-0.008990208,-0.03682071,0.009797512,-0.0033780658,0.04225588,-0.049698886,-0.06906761,-0.030006057,-0.06696667,0.024549201,-0.015285154,-0.0053475355,0.0951729,0.056794334,0.04945584,0.010194147,-0.014456546,0.042206462,0.015935624,-0.048791572,0.013656197,-0.120705314,-0.057966005,0.006114601,0.026483003,0.0832464,0.073966354,-0.01876259,0.024089634,0.012747123,-0.021159146,-0.13022316,-0.09798162,-0.025862923,0.0776839,0.047637634,-0.047239926,0.05196837,-0.0059886617,0.037153933,-0.014143465,-0.0115458565,0.027679589,-0.09538572,0.08803465,0.0044885846,-0.023344854,0.08335791,0.027120356,-0.039101396,-0.024827374,0.0445887,0.0064240447,-0.0046858666,0.018785335,-0.03329049,-0.054596666,0.0008391878,0.11616308,-0.027926406,-3.833796e-33,0.11234887,-0.030774642,0.10532921,-0.10243421,-0.04473167,0.025653707,0.05258599,-0.03569133,0.10829174,0.049359813,0.08283831,0.07784692,-0.0059361863,-0.08188595,-0.026047442,-0.06497989,-0.066425696,0.070705004,0.00038117575,0.0038857826,-0.0508254,0.02747227,-0.0145463,0.12612419,0.08271149,-0.021028677,0.028083362,-0.004198283,-0.060857177,0.13870189,-0.021617847,0.06850774,-0.026202425,-0.014467181,-0.031233573,-0.063448824,-0.11382311,-0.018672893,-0.015863853,0.052821524,-0.0026124294,0.064753346,0.11658956,-0.053458717,-0.0007077194,0.073969856,0.029725082,0.08368321,-0.06715755,-0.026766684,-0.015976736,-0.015863338,-0.05494819,0.07864478,0.0011378012,0.095748566,-0.02314046,0.12687835,-0.04909155,-0.04783939,-0.071230315,-0.08663449,0.020463346,0.0046617403,0.08968105,0.038578406,0.0394953,0.0031752377,0.03698985,0.015208428,0.00936933,-0.05355189,-0.0061409543,0.010463358,-0.041667216,0.027048681,-0.05328561,-0.07344682,-0.025517482,-0.051382557,0.0023248524,-0.0045435447,-0.046166267,-0.07573379,-0.047904365,0.017988097,-0.026732745,0.07199031,0.010787087,0.026053635,-0.016774198,-0.04324708,-0.04922098,0.07083451,0.053763703,-4.7804146e-08,0.07189989,-0.002439742,-0.028332232,-0.069027044,-0.07099834,-0.05882345,0.06667774,0.049675606,0.044362463,0.005370151,0.0022404895,-0.0027244196,0.05382206,-0.03303923,0.028454864,0.05716329,-0.021462537,0.09648614,-0.020582905,-0.02853811,0.06275563,-0.048937064,-0.07401399,0.034332052,-0.02298281,-0.05273605,0.037512425,0.06340256,0.015933583,-0.007883202,0.013090787,0.0018363522,-0.014753884,-0.04863945,-0.025643824,0.039641753,-0.022075105,-0.055056445,-0.0348394,0.02922952,-0.03505946,-0.045797177,0.020991426,-0.03464601,-0.05830634,0.011248312,0.023624836,0.013444289,0.011339075,-0.0039943107,-0.057246152,0.009017008,-0.07753624,-0.08492324,-0.08511131,-0.005155922,-0.016903734,-0.019808808,-0.052538197,-0.081997536,-0.023075214,0.005695155,0.14974327,-0.09963131 +3.1.4.12,Has very little activity on phosphatidylcholine.,384,1.0,0.07760953,-0.048635844,-0.029406304,0.018760165,0.008197275,-0.05005421,-0.028081642,0.050791394,0.013086668,0.010310209,0.048447344,-0.014456943,-0.030068064,0.050787378,-0.019079732,0.0568251,0.011383264,-0.0612213,-0.052859318,0.015128644,0.00083851034,0.018808099,0.058016878,0.0413387,-0.076521486,0.01959456,-0.053260654,-0.09295015,-0.0061484315,-0.046218194,-0.027762214,0.0029844127,-0.008119349,-0.062114518,0.03866765,0.06233875,-0.017914047,0.034029346,-0.020064818,0.026998622,0.07687648,0.024523344,-0.026226005,0.026743343,0.004760104,0.028290313,-0.007688623,-0.08448195,0.012193249,-0.013324901,-0.004445807,-0.06278517,-0.051938713,0.012832638,-0.10055993,0.04236345,-0.10034897,0.099773556,-0.028566029,0.046173297,-0.05717645,0.00019069608,0.042786803,0.062185034,0.033564057,0.008911791,-0.008799499,-0.08189924,0.0701024,0.012706032,-0.01880273,-0.033673763,0.013862909,0.09074128,0.042245388,0.029062897,0.01517611,-0.02156314,0.06944463,-0.057428926,-0.019866852,-0.06449517,-0.06368049,0.11366523,0.008108455,0.029401384,-0.023100521,-0.089559905,-0.04885518,0.026753783,0.027968705,0.023052923,-0.049432654,-0.023081778,-0.04126956,0.038503356,-0.011811849,0.025627648,-0.1364935,0.0076062614,-0.006501093,0.03868625,-0.013436816,0.0058999173,-0.024682933,0.06972608,0.04569424,-0.11525646,-0.09971018,0.025985882,0.007962504,0.0033210092,0.06596162,-0.024332823,0.0012942335,0.02872392,0.039929226,-0.060233388,-0.031008914,0.07106448,-0.0032806236,-0.057523556,0.007303686,-0.059031945,-0.08472053,0.033354044,-0.049565934,1.4802741e-33,0.08527742,0.0032187824,0.021044517,-0.04311309,0.022571823,-0.010121049,0.008420633,-0.04598987,0.04465377,0.011146858,-0.015541005,-0.057501398,0.04367812,0.03528473,0.025608098,-0.0069223507,0.021142306,-0.0017457763,0.09487396,-0.053237777,-0.015932944,0.007307463,-0.053274047,0.008252255,0.047321577,-0.027990248,-0.0103407195,-0.015485389,-0.039042324,0.007850614,-0.013065478,-0.030807005,-0.056586463,-0.04541577,-0.03634168,0.092548005,0.037629083,-0.040566143,-0.0009592384,-0.008075293,-0.043440863,0.0048190937,-0.015666371,-0.02722998,0.005614004,-0.045002863,0.007893724,0.03651857,0.026881445,0.021120228,0.030963274,-0.031217407,0.07896554,-0.009981584,0.007236055,0.010205121,0.03425507,-0.06723852,-0.018596157,0.005612649,0.0313975,0.083979055,-0.09815547,0.007715317,0.06889882,0.071253546,-0.055358265,-0.047131818,-0.080730066,-0.0034434285,-0.006331132,-0.023334192,-0.022140898,-0.0063545303,0.055347756,-0.0715786,0.036194436,-0.009728416,-0.034893878,0.00037553863,0.116618805,-0.019983599,0.08173862,0.0798671,-0.026041389,-0.0040060757,0.015445197,0.060858957,-0.04416851,-0.017817063,0.055269126,-0.028041027,-0.029540291,-0.009043826,-0.018093146,-2.368229e-33,-0.07877927,-0.028016191,0.06947012,0.05722429,-0.026078759,0.11523182,0.022980079,0.05038877,0.08305053,-0.02431369,0.099106416,-0.0124947755,-0.007885467,-0.008540596,0.03540811,0.07487151,-0.109511554,0.034817945,0.07097299,0.012620644,-0.025237279,0.09794609,-0.039035503,0.15538257,0.018110547,-0.021239148,-0.044605106,0.044636354,-0.034277618,0.021992335,-0.006015487,0.003438287,-0.08708666,-0.07628408,-0.05175674,0.034584567,-0.056788333,-0.021467796,-0.09602372,-0.03205694,0.008504589,-0.009750167,0.15356147,-0.07726222,-0.009559972,0.009136681,-0.051852703,0.0007248066,-0.057179775,0.08727865,0.0056393193,0.030846193,-0.041641638,0.034435663,0.071304,0.10805633,-0.0019100615,-0.009952019,0.002804316,-0.09031663,-0.0065381895,-0.025424818,-0.12547803,0.008942367,0.08222703,0.07595985,0.035344534,0.061979976,0.05347424,-0.036262225,0.09608537,0.053563748,0.07831536,-0.08412103,0.020488348,0.12053376,-0.039210565,-0.036130372,0.002018714,-0.0045675808,0.081012875,0.061297487,0.037239514,-0.13336313,0.07624136,0.04123105,-0.11025781,-0.031665877,-0.04327933,0.06386154,-0.019984696,-0.046651218,0.021390844,-0.0050530443,0.016571913,-1.8978753e-08,0.1057764,0.027978584,0.060939286,-0.024242371,-0.03739165,-0.039275978,0.062238865,-0.016565409,-0.04240134,0.03006471,-0.0145966,0.030805405,-0.030314283,0.047241654,0.066674404,0.017022332,-0.018087452,0.036338262,-0.036935978,-0.052629493,-0.050430615,-0.0069299405,-0.062266864,0.0070106103,0.04171727,-0.04418744,0.12152603,0.026564859,-0.032225803,-0.023479061,0.028521702,0.016179267,-0.034707066,-0.027223004,-0.07053303,0.0047433055,0.048242338,-0.004230827,-0.11100124,0.0761597,-0.1003637,-0.04242882,0.034980588,0.011009669,-0.07433775,-0.05548491,0.032951463,-0.020211546,0.042643197,-0.06277978,0.037503008,0.031521782,-0.018189188,-0.06689362,-0.11116758,-0.0021569903,0.02471781,-0.016512144,-0.05376177,-0.08771842,-0.0008694191,0.008726677,0.07956823,0.011049378 +3.1.4.13,Acts only on those phosphodiesters that have ethanolamine as a component part of the molecule.,384,1.0,0.07272218,-0.06396545,-0.039770115,-0.03103572,0.111161776,0.065010436,0.009490314,0.0010405525,0.031153731,0.03324591,0.03302668,0.013507086,-0.10929168,0.14106001,0.028244423,0.098537005,-0.04404394,-0.058859188,0.09930301,0.026741698,0.10272506,0.008096863,0.011642319,-0.019045377,0.005936717,0.096469514,0.014647269,0.06296331,0.067689024,-0.04332963,-0.01988517,0.05670354,-0.055365555,-0.016844738,0.015606983,0.01084246,-0.047216065,-0.0027950213,0.0145070525,0.004301078,0.0952657,-0.019316396,-0.04459721,0.00049595034,-0.0499367,-0.017340053,0.0010985576,0.093616605,0.048326798,0.0019936112,0.032348037,-0.017829113,0.038351163,0.049510553,0.0018070485,0.03761925,-0.10279968,0.010927597,-0.03342086,0.011367983,-0.07176783,0.05308996,0.00607107,0.045613132,0.0823254,-0.018051853,-0.013423746,-0.0050718207,-0.023634447,-0.010978142,-0.037416287,-0.070826165,0.124056354,0.043791953,0.07145634,-0.03066324,-0.033671577,-0.017567765,-0.006489521,-0.033976763,-0.078181595,-0.040669158,0.079845235,0.0121116815,0.020919098,0.023420677,-0.06060041,-0.032914337,-0.05101219,-0.003377854,-0.027522825,-0.074108265,0.0060742605,-0.10079616,0.05545001,-0.01835236,0.03447756,-0.011770438,-0.0034811622,0.0012060644,-0.013811036,0.05796069,-0.039199974,-0.08288503,-0.042349435,0.023411902,-0.014361669,-0.05948666,-0.06931718,0.040431164,-0.000966776,0.008813523,0.08889431,-0.019932825,-0.054417823,0.028877223,-0.019235672,-0.028535314,-0.049527816,-0.01929585,-0.04361244,0.02651832,0.06174025,0.098485224,-0.036086272,0.04319934,-0.03668493,-3.375623e-33,0.01970788,-0.004771969,-0.028101796,-0.079222366,0.014801059,-0.023698427,0.024100281,0.0023151804,0.026362367,-0.010556165,-0.039827388,-0.024977174,0.08173209,0.068821244,0.033671413,0.05349604,0.0030775508,-0.015586905,0.06685415,-0.08024185,-0.013379638,0.025531521,-0.061466504,0.053867392,-0.065056115,0.0058813803,-0.0012444105,0.03238406,-0.0025852497,-0.022913555,-0.056551915,0.0613132,-0.04867228,0.045246158,0.07806483,0.10162157,-0.054804135,-0.015583891,-0.043074373,-0.026874626,0.04385165,0.0015116492,-0.02726023,-0.016512983,0.010225043,-0.021587191,-0.11546588,-0.026588634,-0.020330114,0.0574126,0.07504966,-0.06423799,0.0343361,-0.01547541,-0.062229503,0.030381456,-0.022112308,-0.085327186,-0.033806384,0.0029169244,-0.109829545,-0.020578988,-0.059933994,-0.052280664,-0.060311645,0.043049086,-0.056384526,-0.124022305,-0.063076906,-0.007482061,-0.03251144,0.04472249,0.0799137,-0.024971994,-0.017576095,0.026503481,-0.016793814,0.01156906,0.015905648,0.05309468,0.0165817,-0.08929701,0.018595602,0.02461249,0.004011595,-0.08021674,0.046387922,-0.10032077,-0.0320725,-0.026622694,0.08383809,-0.068277285,-0.03546434,-0.006624911,0.0037970645,-1.0453461e-33,0.010859318,-0.06574068,0.038953267,-0.03677305,-0.03307112,0.047848545,0.07380103,-0.019710643,-0.010195301,-0.033513706,0.06752317,-0.014347634,-0.119708404,-0.03790016,-0.02795214,0.04852823,-0.0022568493,0.08314942,-0.02133582,0.03235892,-0.052721597,0.109416164,0.0658129,0.0981091,0.07962407,-0.03680723,0.054898724,0.003825083,0.0044618654,0.03051163,0.0148586575,-0.019407189,-0.0896663,-0.07884571,-0.0018107697,0.0062354617,-0.08388277,-0.008157274,-0.054818265,-0.015675927,0.012304644,-0.008069331,-0.005960651,0.043870077,0.049938012,0.027852418,-0.02251955,-0.0049131275,-0.12494994,-0.02734187,0.0015088781,0.0062633515,0.033194378,-0.0007979914,0.027853886,0.049250674,0.06427342,-0.019326549,-0.017587548,-0.0015860935,-0.026725147,0.07260209,-0.07907203,-0.00368771,0.063307144,-0.084661044,-0.011624061,0.08205602,0.090038,-0.0014910451,0.07577282,0.017438756,0.071166255,0.0884381,-0.02586143,-0.056950316,-0.04710305,-0.07581669,0.005745509,-0.054074854,-0.064712174,0.03917468,0.0051954067,0.007815878,0.03728776,0.015753848,0.03785125,0.0049524736,-0.015084683,0.044704065,0.045580678,0.03823086,-0.038510617,0.0056368774,0.04231696,-2.3520201e-08,0.051531006,-0.01708223,0.02052414,-0.07490607,-0.038567998,0.03657418,0.078491494,-0.01632782,-0.0040153028,0.032172572,0.04501867,0.037714776,0.037202917,-0.0013745362,0.075122684,-0.0244631,-0.052486558,-0.027214019,-0.08144214,-0.09476308,-0.10850323,0.024391701,-0.10147504,0.08809237,-0.0041270815,-0.048971694,0.010088328,0.020672873,-0.04326097,0.03168342,0.017513027,0.026071848,-0.07110543,0.0028180925,-0.021026723,-0.003961289,0.053302836,-0.041097064,-0.08470101,0.014997981,-0.041497167,-0.014880359,-0.021330792,-0.005141679,0.023663092,-0.0020204394,-0.0194691,-0.0627798,0.055898212,0.008346605,0.057462983,0.050562453,-0.0187546,-0.040448736,-0.13665412,-0.07767723,-0.053784106,-0.0619802,0.05445277,-0.06331391,0.08368497,0.038259547,0.16102447,0.034080558 +3.1.4.14,"The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [3]. Deletion of the gene encoding this enzyme abolishes ACP cofactor turnover in vivo [3]. Activation of apo-ACP to form the holoenzyme is carried out by EC 2.7.8.7, holo-[acyl-carrier-protein] synthase. ",384,1.0,-0.03585132,-0.02696767,-0.081463255,0.038896233,0.047350626,0.06589149,-0.046963062,0.0043711946,0.006898252,0.0011940276,0.12442083,0.0030594035,-0.100113966,0.056438603,-0.009102771,0.082987934,-0.070865296,-0.040188715,-0.0055661905,-0.08378257,-0.009789464,-0.0011086856,-0.065032125,0.024745157,0.04514969,-0.09608555,0.021205427,-0.049226254,-0.04897723,-0.034702804,-0.058029436,-0.03505639,-0.005504198,-0.024200492,0.066847056,0.013731812,-0.04254197,-0.1163364,0.081346385,0.020033564,0.060791768,0.03978778,-0.015066149,0.044199724,-0.009514499,-0.05223874,-0.05945371,0.06703749,0.029876368,0.0016370283,-0.0077536637,-0.006163175,-0.014181675,0.0071942857,-0.058054052,0.057133242,-0.028742759,-0.058319654,-0.022221847,0.005051897,-0.0046511036,-0.034723237,-0.017828694,0.018483918,-0.005092927,-0.041626107,0.08046919,-0.029101128,-0.0008634396,0.031420536,-0.040693972,-0.061939932,-0.037525106,0.04955412,0.05527564,0.012610976,-0.050761957,-0.011707466,0.074443296,0.012119156,-0.004030973,0.04634973,0.046775512,0.014968373,0.039334394,-0.044983227,0.05165735,0.017267581,-0.07516927,0.005411477,-0.042246394,-0.051888414,0.038570374,-0.00914212,-0.079193585,0.08847751,0.07075078,0.04936743,-0.07195914,-0.09286447,0.024054913,0.016711581,0.046981346,-0.047282536,-0.055698276,0.003978091,-0.011706072,0.08243206,0.021463593,0.026458083,-0.03620716,0.040445622,0.018850617,-0.043177612,0.032501873,0.11475113,-0.07325124,-0.013178926,0.020981,0.03936909,-0.029387118,-0.01115985,-0.019032184,0.09893788,-0.0028667396,-0.050754286,-0.079029,1.0392874e-33,0.03931799,0.019590182,-0.008958356,0.016324725,0.040841676,-0.05824923,-0.099472955,0.051573116,-0.08671116,0.0065030875,-0.02662022,-0.08128533,0.057312667,-0.018716928,0.014249188,-0.056819923,0.0024662588,0.032415487,0.089873,0.058926426,-0.047164645,0.0752305,-0.0019379386,0.030502418,0.03537507,0.057690192,-0.05769574,0.008057675,-0.015248476,0.015917474,0.0136040505,0.00928999,-0.0667302,0.013686864,-0.0061042043,-0.058797993,-0.013317231,-0.078805484,-0.028385768,0.012990696,0.14220986,0.048290677,-0.019767325,-0.0056535485,0.0665041,-0.022904102,-0.08693623,0.008817761,-0.027657527,0.091083735,-0.00878826,-0.0036148007,0.03518239,0.028102769,-0.094977215,0.0023674837,-0.10556775,-0.025732705,0.061224442,-0.04982571,0.036574606,0.07742798,-0.043804955,0.011022069,-0.07869111,0.03449303,-0.07367557,-0.02849628,-0.017975064,0.13630678,0.0016183951,-0.030981317,-0.04677127,0.045410458,0.04566847,-0.036107667,-0.039037988,0.02953213,0.031449307,0.053331647,-0.003980647,-0.047439236,0.0685362,-0.027157558,0.009245111,-0.09534969,-0.05002153,0.02815594,0.075982474,0.025066465,0.0910767,0.023913419,0.027776057,0.07200392,0.027264478,-2.4872313e-33,0.15966742,-0.10482427,0.05065129,-0.11913951,-0.08402014,0.05852851,0.0045000943,-0.015049626,0.0048586177,-0.047996532,0.07317025,0.023357531,0.009021629,-0.09498147,0.07474676,-0.00088558457,-0.03238711,0.041609317,0.09144647,0.048535988,-0.033159077,-0.06250538,0.024859034,-0.012031983,0.03848645,0.017567089,-0.032704152,0.0012707203,0.08460013,0.012865012,-0.028897222,0.0048525264,-0.009916807,0.017565776,-0.09698648,-0.0037229534,-0.045222167,0.07036303,0.035457045,0.0480024,-0.0011290464,-0.009878348,-0.018023312,-0.02516167,0.067753166,0.055717688,-0.008588714,-0.04110509,-0.02144205,-0.09500959,0.07716562,-0.00030621077,0.009691407,-0.05202247,-0.037428997,0.11266945,0.0050440775,0.0087237405,0.06075579,-0.069457896,-0.03388446,0.024274793,0.02041822,0.039305415,0.0022791242,0.05431002,-0.025638591,0.021470271,-0.061663423,-0.02888354,-0.02330151,0.11407191,-0.027721548,0.03581424,0.016822023,-0.015695276,-0.07961606,-0.033857618,-0.017089063,0.0020056402,-0.0778593,0.02833368,-0.031527743,0.017542794,-0.06536985,-0.009619083,0.023748552,0.02716051,0.013134666,0.075190514,-0.010098052,-0.014095455,-0.028368535,-0.00028667867,0.036429323,-4.176693e-08,-0.008084333,0.021749174,0.04176411,-0.06564889,-0.009625794,0.03895267,0.033903226,-0.016403265,0.05269528,-0.01123934,-0.027445924,0.05584367,0.018035373,0.08396323,-0.007341623,-0.05420221,-0.030525146,-0.014382428,0.050199013,0.02134489,-0.075192176,-0.0010046767,0.017534068,0.09746556,-0.04762142,-0.016921287,0.052259114,0.05232557,0.019043729,-0.06419175,-0.05890327,0.03152271,0.00073636323,0.0100193955,0.001086405,-0.011890331,0.02682058,-0.09634992,-0.08043146,0.07073689,0.033257082,0.012349335,-0.042699944,-0.02171442,0.1040761,-0.035065886,0.086686075,-0.04522641,-0.037902903,-0.011917996,0.081211776,-0.00058726076,-0.07023171,-0.074646436,-0.02223062,-0.025405107,-0.011262201,-0.14047582,-0.04420671,-0.050252277,-0.02164616,-0.028433582,0.15362957,-0.06619663 +3.1.4.16,"Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides. Similar reactions are carried out by EC 4.6.1.24 (ribonuclease T1) and EC 4.6.1.18 (pancreatic ribonuclease).",384,1.0,0.0042213225,-0.05339384,-0.03943952,-0.11022623,0.0012838372,-0.006665019,-0.013099532,0.010865126,0.06522716,0.07801105,0.018444482,-0.0070119807,-0.038520604,0.06663973,-0.05477699,-0.03330054,-0.091432475,0.044066027,0.030079888,-0.026404532,0.05587306,0.057069752,0.022833917,0.022465693,0.046863575,-0.01801118,0.05668778,-0.022355312,-0.029375907,-0.054924153,-0.031536307,-0.09022656,0.07864717,-0.05956435,0.04433862,0.091825195,-0.041964903,-0.043531585,0.02081895,0.05208952,0.0951549,0.0071918885,0.0783338,-0.0061064325,-0.015739312,-0.008803772,-0.029281488,-0.0036035331,-0.00891366,0.024642909,0.052226968,-0.06127417,-0.031062406,-0.036621153,0.037430443,-0.013438299,-0.06844819,0.027101317,0.015367457,0.06406704,-0.00821174,-0.008822218,-0.0140442755,0.015399549,0.095625125,0.027834184,0.088481955,-0.040323652,-0.03059182,-0.023336483,-0.011362538,-0.032531433,0.023880342,-0.012763343,-0.05707103,0.04688389,0.031318784,-0.03177224,-0.0063577592,-0.04447856,-0.049018603,-0.01969213,0.013407841,-0.00610454,-0.0050153383,0.017348243,-0.057016518,0.039746393,-0.052200183,0.01371674,0.004357673,-0.03560272,0.04449547,-0.06652114,0.0048892424,0.02521878,-0.021351352,0.07034131,0.002812463,-0.06974199,0.045345597,0.16696553,-0.073902145,-0.06979012,0.03984923,0.14506195,0.0028522867,0.012030265,-0.035543423,0.059899963,-0.018800797,-0.0043797507,0.028673893,-0.040941957,-0.02601082,0.057141192,-0.002881251,-0.062176585,0.011291189,0.007280961,-0.004236047,-0.07664593,0.048933636,0.050218254,-0.06654366,0.07802947,0.006170916,3.7189747e-33,0.045757595,0.030476999,0.023523021,0.02913546,-0.017134449,0.032040946,-0.05427388,0.019307407,-0.081382364,-0.0131535,-0.091963604,-0.01777025,0.12223153,-0.027381778,-0.071326256,-0.033580095,8.433591e-06,0.026839731,-0.0012651968,-0.023275461,-0.0036432939,0.091925785,-0.020387238,0.042026933,0.036967482,-0.017529195,-0.09784123,0.028609091,0.12570925,-0.05219165,0.020463755,-0.049043927,-0.060156893,0.047813985,-0.000710811,-0.022567136,-0.054822087,-0.007895905,0.038380295,0.10183612,0.010577266,-0.07764356,-0.018321838,-0.034785464,0.06846769,-0.0021006693,0.0058186837,-0.016841155,0.020890255,-0.009185273,0.058025356,-0.027950183,0.049467374,-0.07198703,0.02048034,-0.05358429,0.020599866,-0.008441295,0.097696096,0.09924362,-0.019076189,0.07929213,-0.045224376,-0.043148004,0.024790604,0.035108935,-0.07031857,-0.07987364,-0.013085126,0.021492353,1.6854023e-05,-0.047761835,0.08351168,-0.01312668,0.021440227,0.014090927,-0.03570337,-0.018815612,-0.031104105,0.06781314,0.029808369,0.011835538,0.0018039007,-0.020528475,-0.01285394,0.04500896,0.015595608,-0.08272544,0.0030128327,0.10432453,0.031482443,-0.038961474,-0.09801011,-0.061858743,0.029063191,-4.840787e-33,0.0622751,-0.06685585,-0.02184234,-0.06585025,-0.10512578,0.001561333,0.03846546,-0.038859736,0.0886782,-0.055413563,0.088578135,-0.06405343,0.027457666,-0.09669922,-0.00822931,-0.011227684,0.0021404035,0.06779182,-0.0065389853,0.023864238,0.03538898,0.09571144,-0.03677417,0.06550846,0.064906836,-0.0152525585,-0.011164351,-0.008660778,0.052251596,0.035324723,-0.08604712,0.011118885,-0.0029911017,0.024619646,-0.04479578,0.0119068725,-0.08344949,0.012070494,0.0066361967,-0.013430459,-0.06040002,0.07250346,0.08051395,0.09411363,0.033792652,0.045922548,-0.07301118,0.0014591765,-0.025095288,0.018186744,-0.0153547125,-0.007109,-0.049387533,0.05157041,0.0558947,-0.0022429067,-0.038402207,-0.007829244,0.05213303,-0.068026714,-0.028499536,-0.09588231,0.044502463,-0.080453254,0.068790495,0.061388522,-0.10751305,0.049075685,0.010220231,-0.011552117,-0.01060634,-0.02560649,0.02279658,-0.044353843,0.0066203116,-0.03407941,-0.090422705,-0.016637899,-0.02783961,-0.063985206,-0.034310948,0.05326825,0.002933188,-0.04858042,0.036502834,-0.045363303,0.047984067,0.08500782,-0.039610334,0.0106840795,-0.009064666,0.023166524,0.024109257,0.032792073,0.054815676,-4.200518e-08,0.05924179,0.016116627,0.05847986,-0.035334088,-0.013875072,0.027555432,0.04763842,0.06284696,0.022065653,-0.024872476,-0.034673065,0.050390907,-0.020502253,-0.07568811,0.08763537,0.026698077,-0.13838188,-0.0118566,-0.00043747236,-0.011032704,-0.03106572,0.06039314,-0.11393637,0.05755631,-0.07289528,0.06259648,0.06692863,-0.0062483423,0.038912337,-0.06589134,0.03508663,-0.019425001,0.016394813,-0.13082936,0.015907375,-0.007945351,0.02361795,0.048884764,-0.047597192,0.014425303,-0.060992405,-0.102856174,-0.06555418,0.04662083,-0.08036118,0.0052335393,-0.037488542,0.10705351,-0.042478375,-0.029974991,0.018842643,-0.058500305,-0.0338532,-0.046682846,-0.018459322,-0.032861017,0.0088739265,-0.06582069,0.0007274343,0.036574595,-0.0024649887,-0.04104808,0.17988561,0.019172031 +3.1.4.17,"Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.",384,0.99999994,-0.10986483,-0.06275953,0.055955384,-0.011277413,-0.026729222,0.017740378,0.04021992,0.009078036,0.014515002,0.049371485,0.061208233,-0.03287443,0.03484889,-0.0375588,0.014833895,0.062625214,-0.06874485,0.039020956,0.039944466,0.025407882,0.08588066,0.019047849,0.014653936,0.03971031,-0.031374298,0.0007035708,-0.07544615,0.06629028,0.0007018446,-0.1195467,-0.05867405,0.0014282276,0.0010447135,-0.0661819,-0.0856682,0.10179091,-0.0850828,-0.0007378092,-0.00043196027,0.04759093,0.058702286,-0.027984906,0.11614666,-0.07033401,-0.00625991,-0.037886735,-0.009461975,-0.03385688,-0.052593917,-0.063954696,0.0019007658,-0.05363058,0.029609846,0.1041717,-0.045950655,-0.0402647,-0.089370556,0.058394995,0.081477106,-0.034827895,0.034659117,0.033114705,-0.0674294,-0.007532152,0.00957108,0.062889375,0.0027113443,-0.06138117,0.003920487,-0.012968892,-0.09320882,-0.15042987,-0.024385808,-0.114960104,0.032996573,-0.019466784,0.0032716002,0.0012539504,-0.012782386,-0.07758804,-0.025146864,-0.052328244,-0.044748705,-0.026246144,-0.009797998,0.064605415,0.0034746581,-0.009838296,-0.030588673,-0.006099435,-0.004749772,0.03045438,-0.0439408,-0.02532049,-0.057674102,0.01086154,-0.0012025682,0.008281437,0.072025836,0.08426799,0.08684482,0.03273803,0.00061746064,0.01544492,-0.07634312,-0.022889018,0.0063160923,0.028739827,-0.07313496,0.0036990305,-0.06375694,-0.053641327,-0.073270634,-0.10890078,-0.0010707923,-0.030128714,-0.029196475,0.058781214,0.074110486,-0.021184731,0.054872286,-0.037436068,-0.021248996,0.06089285,-0.043145433,0.08904994,-0.054467347,-3.1123512e-33,0.013947798,-0.008318984,0.054589603,-0.02875411,-0.030872758,0.0018391061,-0.013366255,0.063083924,0.0022958333,-0.047600027,0.034025934,0.062023234,0.08262313,-0.026846822,0.008140433,-0.090683274,-0.043447584,-0.03824063,0.04611076,-0.0762696,-0.03494671,0.14587164,-0.06265638,0.033921633,0.03686427,0.01625901,0.000812304,-0.016314235,-0.04671644,0.008298346,0.027799578,0.03972397,-0.04100143,0.038171906,0.056598645,0.075086646,-0.040351592,0.009289615,-0.012816478,-0.044247773,-0.040937703,-0.063199185,-0.04628618,0.013835909,0.017887408,-0.009929142,0.008456788,0.024581768,0.03047351,0.032836884,0.09955461,-0.013095332,-0.013655026,0.009184976,0.00028406942,0.026679942,0.011460917,0.028960496,-0.025396459,0.0915228,0.03785223,0.025988286,0.025127359,-0.086223446,-0.07059708,0.059321538,-0.117128424,-0.04711274,0.15371525,0.036577832,-0.039253917,0.03363075,0.079833984,0.06206992,0.024406992,0.03122791,-0.04870043,-0.10159096,0.009972397,0.10366643,-0.10970403,-0.07544292,0.033531606,-0.033157386,-0.006959607,-0.03680521,0.012144868,-0.071980245,-0.032621875,-0.036551084,-0.0054180487,-0.007872542,0.037704766,0.050120782,0.0128216455,1.4951828e-34,0.07911085,0.029279174,0.04238972,0.047471307,-0.001864059,-0.009618822,-0.06317586,-0.028632596,-0.018625615,0.044891313,0.08616593,0.014836592,0.034038696,0.027221415,0.05477797,0.023224311,-0.013948695,-0.011220541,0.028345324,0.06684728,0.081493996,0.046983127,0.012198854,0.06663823,-0.009305094,0.023350991,-0.012070672,-0.014579661,0.079246126,0.041769363,-0.04117634,-0.043736767,0.014230842,0.027245576,0.006802502,-0.016480453,-0.032981433,0.07843471,-0.034741618,-0.042299077,-0.049486402,0.012132058,0.081005044,0.08261131,-0.007565903,0.057570774,0.07816203,0.040365517,-0.10033608,0.021213923,0.023337359,-0.04369781,-0.056192096,-0.03888855,0.02442853,0.048482936,0.0868335,-0.00070851704,-0.035620444,0.0068684835,0.020398866,0.026800347,0.052859776,-0.039187033,0.001979198,-0.010489459,-0.0053813336,-0.07000206,-0.026285216,0.0037499187,0.011453396,-0.013376939,-0.0030103254,-0.15479852,-0.04885789,-0.013175708,0.054214448,-0.026008567,-0.05153117,-0.05487458,0.039805636,0.07570435,0.042926554,-0.018588502,-0.13024245,0.0038064125,0.036022168,0.03240101,0.0507932,0.08138278,0.0146495225,0.12344954,0.06701971,0.056881227,-0.012047477,-2.8432142e-08,0.030063381,0.016693693,0.0052134143,-0.04895139,0.06582855,0.0109242685,-0.0057629533,-0.074799225,0.025502108,0.019619104,0.10090611,-0.020213706,0.0026046806,-0.0021458522,0.05348958,-0.044018913,-0.065541856,0.07699925,-0.05816787,0.016861385,-0.112329945,-0.04130247,-0.026197461,0.011853576,0.041331768,-0.045988515,-0.044663295,0.0024602874,-0.026547665,0.03900278,0.0016305347,0.022106055,-0.035157673,-0.037520677,-0.09806432,0.04642089,-0.04288259,-0.08189688,-0.10286603,0.035784062,0.022653349,-0.06309373,-0.013684687,0.032638744,-0.008963873,-0.021588236,-0.06732384,-0.065887965,-0.02468487,0.021879902,-0.05357591,-0.04499471,-0.03816183,0.019186677,-0.014624836,0.046762604,-0.004740887,-0.050023794,-0.020151632,-0.05941931,-0.028123658,0.032301415,0.07815864,0.01679518 +3.1.4.37,"The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.",384,0.99999994,-0.003932921,-0.09830411,0.015112712,-0.06272369,-0.01015034,0.0032456086,-0.045414984,0.03044796,0.02497501,0.07228277,0.056959383,-0.04113554,-0.03501304,0.12198995,0.011689926,0.049140345,-0.06930236,-0.011669229,0.08664462,-0.0053692744,0.03258362,-0.026744455,-0.04520108,-0.010520654,0.03771489,0.050467312,0.03722261,0.015449439,0.0035172866,-0.057734184,-0.046919987,-0.008511904,-0.016737461,-0.024670847,0.002886069,0.107284196,-0.14643426,0.013343416,-0.048427857,0.033179197,0.067997016,0.02507777,-0.017678063,-0.023779018,0.0045179646,0.0044299127,0.0045830426,0.0064427885,-0.02676867,-0.05128456,-0.048301972,-0.03338809,0.010530074,0.026743006,-0.09574344,0.012573533,-0.09466875,0.06210151,-0.00076783425,-0.021855783,-0.05983425,-0.0017958932,0.029763274,0.018952046,0.13996759,0.006322692,0.013423648,-0.1105543,-0.02607896,-0.017257096,-0.015446194,-0.12218823,0.032657426,-0.055512503,0.009911333,-0.045922384,0.015823025,-0.019148748,0.071704656,-0.097853765,0.0042766854,0.002189392,-0.004246188,-0.014475503,0.055442084,0.025059145,0.00088483514,0.06925918,-0.08996326,0.0196891,0.0030808242,-0.02626225,-0.013360831,-0.0263373,-0.004217373,0.0030950657,-0.030898482,0.043498468,0.031805083,0.012855554,0.08316103,0.12497516,-0.074871875,-0.016231677,0.02228012,0.025704764,0.020754008,0.0117914425,0.015841624,0.006595149,-0.040706698,0.051600043,-0.003750565,-0.01212052,0.0008429901,0.08813329,-0.041064776,0.007092305,0.0976326,0.03919233,-0.007889905,-0.10122727,-0.048315965,0.038174458,-0.016135467,0.12521257,-0.047800094,1.4662572e-33,0.017340956,-0.049903065,0.028283024,-0.10024736,-0.0075133364,0.037717834,-0.022907052,0.041819047,-0.011747212,-0.073744245,-0.0179736,-0.051365953,0.040606078,0.047912784,-0.022814697,-0.10033734,-0.06701209,0.025744447,0.12860633,-0.10091809,-0.007848721,0.0050890055,-0.07700182,0.06797528,0.048886467,-0.010022841,-0.09304253,0.09482075,0.021528928,0.015890544,-0.010682905,-0.018738171,-0.10183384,-0.032412753,-0.02174276,0.008401298,0.0044772006,-0.017812418,-0.0066679483,0.062332556,-0.050971255,-0.054762065,0.03553145,-0.006190239,0.031258114,-0.043953672,-0.13020867,0.049611207,0.009658135,0.0001001559,0.066617705,-0.050560065,0.07199036,-0.04406609,0.02139877,0.014564518,-0.05806809,0.012501885,0.015747923,0.06944753,0.101777375,0.065388426,-0.027168564,0.061390925,-0.0019227301,0.041118678,-0.100133836,-0.061359398,0.05738963,0.11076989,-0.029765995,0.04058723,0.061925557,-0.025752919,0.051729757,-0.007466202,0.03384686,0.0056711226,-0.006076172,0.011345925,-0.005321244,-0.064862706,0.048100665,-0.03378662,0.04613438,-0.045769554,0.029659515,-0.07960948,-0.030394087,0.00582757,0.074985445,-0.0074619716,0.004382486,0.03829643,0.012495913,-2.8219825e-33,0.059075817,-0.05057521,0.06465813,-0.0023232142,-0.028964914,0.008815933,0.017069424,-0.011901652,-0.019908162,-0.020114914,0.07683925,0.0059145507,0.012017176,-0.036764525,0.06183803,0.0062053427,-0.0092568835,0.048350215,0.0702454,0.031603817,0.010118305,0.07222235,-0.0051867315,0.08753765,0.041117318,0.014825875,-0.063663594,0.04357678,0.06579023,0.053186685,-0.095369846,0.058238547,-0.070182,-0.0027079247,0.017164903,0.015548033,-0.09873456,0.014985879,4.1670395e-05,0.06843603,-0.0112224305,0.040580522,0.045500897,0.025099764,0.031161426,0.07332268,0.032504015,0.024001142,-0.076100826,0.013016214,-0.023793617,-0.011711348,-0.03650098,0.011469221,-0.012170251,0.036666073,-0.031551328,-0.0077476064,0.01277537,-0.058047537,-0.019166471,-0.02518729,0.00037408262,-0.013337529,0.016603714,0.055529434,-0.011523862,-0.008995311,0.031641953,0.017426547,-0.014939789,0.010459736,-0.007782574,0.021052016,-0.06405298,0.028850581,-0.007751339,-0.0059432043,0.028426275,-0.11146355,0.030990258,0.059170537,0.012936084,-0.053023048,-0.07824455,-0.040381685,-0.026318522,0.038128365,0.031729758,0.020728817,0.0065996167,-0.0076883393,-0.012396765,-0.007133012,0.010925973,-4.1647745e-08,0.040463228,-0.09510605,0.040655784,-0.039653055,0.06383069,0.0057030898,0.025577657,-0.06836862,0.056134228,-0.049022093,-0.0036983776,0.030772384,0.044996746,-0.008795771,0.089813665,0.03428399,-0.068060376,0.014306221,-0.00987399,-0.05665017,-0.11280244,0.01573349,-0.026213,0.09684053,0.006583202,0.0543352,-0.0053282143,0.13217878,-0.05965153,-0.019245833,0.012833007,0.04325838,-0.0486108,-0.0074548237,-0.080728196,-0.034658182,0.014342665,-0.03141018,-0.104665525,0.020918826,-0.03291175,-0.14182101,-0.0498583,0.008735209,-0.038439382,-0.06878055,0.028247753,-0.018421657,0.016372234,-0.081229836,-0.012760523,-0.017773245,-0.049817245,-0.059882864,-0.00079815,-0.0359027,-0.026996398,-0.116325006,-0.071039736,-0.07662689,-0.012078626,0.11631078,0.17703928,-0.059008412 +3.1.4.38,No activity on sn-3-glycerophosphoethanolamine.,384,1.0,0.049061477,-0.07979067,-0.07217737,-0.019195909,0.033395693,0.015439182,-0.014107654,0.005757875,-0.04509437,-0.015018144,0.012615433,-0.04961948,-0.024434617,0.052304365,-0.040614776,-0.0051258686,0.027885646,-0.10027449,0.03843166,0.028747834,0.014225947,-0.0057436214,0.07278746,0.062236562,0.030632045,0.06897662,-0.04828252,-0.027203236,-0.014454769,0.014413504,-0.017778192,-0.028754793,0.02665136,0.016561363,0.070963964,0.04342426,-0.043497838,0.060181238,-0.06897122,0.085605204,0.03343746,-0.05051391,-0.082241036,-0.04278136,0.04703614,-0.009878747,-0.007954197,-0.08490951,-0.034915853,0.052605603,0.07246268,-0.12154282,-0.006771049,0.005358607,-0.025158528,-0.0021937806,-0.1151315,0.103600726,-0.03713836,-0.006986162,0.017188875,0.03396411,0.06508607,-0.014310177,0.07227652,0.0076660025,0.04113795,-0.09752002,0.028127072,0.0656425,0.056165334,-0.046337355,-0.0076180524,-0.044922084,-0.056071885,0.037393957,0.0031325144,-0.009331973,0.035480145,-0.06407174,-0.03342801,-0.054357693,0.028026182,0.13810597,-0.026478864,0.022876639,-0.07881245,0.010595017,-0.03372912,0.022166738,-0.02917204,0.008082646,0.0112139145,-0.035787866,-0.003245412,-0.02830509,-0.057494964,-0.034311377,-0.10234445,0.032201774,0.008815872,0.06482358,-0.03590835,-0.03517831,0.026757931,0.10717986,-0.013719497,-0.05198536,-0.014442029,0.0039433907,0.008863897,0.061773147,0.07995085,0.04930759,-0.0650815,0.087622695,-0.02798903,-0.019327167,-0.011114978,0.033024866,0.00037132323,-0.06323465,0.033549678,0.04084714,-0.045446116,0.081882,0.012309668,2.9043549e-33,0.076676756,0.02363804,0.013366951,-0.04387477,0.008926184,0.049684823,0.02437494,-0.00040053242,0.034610633,0.003069303,-0.05817127,0.04952289,0.03045547,0.0412855,0.021299336,0.014244474,0.034953322,-0.019617232,0.08876785,-0.11060894,0.06252673,-0.09457818,-0.04007338,-0.0075750765,-0.007239027,0.033085123,0.016717887,0.046676412,0.01339022,-0.01340607,-0.029648509,-0.05844039,0.02584189,-0.025670243,0.007132392,0.025246842,-0.00523363,-0.00015570546,-0.010401242,0.031835955,-0.011420997,0.017134164,0.03574581,-0.0607941,0.031159969,-0.010364415,-0.08860478,-0.008694677,0.0045503676,0.007466305,-0.00923999,-0.09404347,0.073337846,-0.011670856,-0.027829912,0.03055276,0.022705164,0.031706963,-0.05343482,-0.045808464,0.040808324,0.05483547,-0.027529951,-0.09227991,0.06374495,0.08265461,-0.07617577,-0.04373306,-0.07651826,-0.109153576,0.0061795744,0.046608537,0.059609644,0.04293069,0.015243791,-0.04174462,-0.020925438,0.038713682,-0.046021372,-0.012634378,0.07900118,-0.053935543,0.015046121,0.016954588,-0.039221648,0.0050030034,0.04709659,-0.062516645,-0.06936455,0.0047997753,0.060976338,-0.058696568,-0.04259323,0.03095679,-0.049109474,-2.609614e-33,-0.03701566,0.005808738,0.04395676,0.0025126357,-0.008408095,0.0874276,0.012234741,0.04009683,0.04638416,-0.038871266,0.10541143,-0.00894912,-0.006543304,-0.056192607,0.005020442,0.072079375,-0.053150922,0.029362245,0.022502838,-0.0027681561,-0.0028943927,0.054859057,-0.095444195,0.118144654,0.0045471834,0.006396576,0.06468118,0.04374972,-0.04493978,0.034245085,0.065791406,0.01928762,-0.088730484,-0.12684335,-0.022346137,-0.0021037438,-0.00798519,0.031237818,-0.055946592,-0.09858242,0.05405219,0.05450232,0.0797124,0.07973174,0.04441401,0.070215255,-0.09505204,-0.057878193,-0.011273682,0.042242453,0.00943764,-0.09815857,-0.029364286,0.01736683,0.13915093,0.070023164,0.018058365,-0.027481548,-0.061084703,-0.090496525,0.00838734,0.022100702,-0.044083584,0.028177384,0.07596698,0.121825986,-0.056786187,0.043117635,0.14394276,-0.019882178,0.042483307,-0.03423932,0.05083759,-0.0045441934,-0.0130218705,0.010097064,-0.04935078,0.020327326,0.048454296,-0.13986243,0.07016298,-0.0028429786,0.0034427268,-0.05284472,0.06447412,-0.004724081,0.000284158,0.0993668,-0.023209065,0.032411408,0.0049616788,0.021897672,-0.05112457,0.0080635855,0.044502735,-2.2763244e-08,0.10839047,-0.058309,0.037918147,-0.028981678,-0.042906288,-0.0004751163,0.14214627,-0.0065206243,-0.018172974,-0.08660076,-0.0493509,0.004553846,0.030993955,-0.09993363,0.04936997,-0.010896766,0.0446792,0.07590049,-0.044238653,-0.060543306,-0.09108512,-0.040669337,-0.030957444,-0.008636474,0.0606841,-0.03698095,0.027835619,0.037309326,0.034654792,-0.011527802,0.0008317002,-0.030273482,-0.00494008,0.03526083,-0.05227525,0.0102657825,-9.726197e-05,0.029477596,-0.028562155,-0.0058843736,-0.10256483,0.032603454,0.012737458,-0.00023142541,-0.007754297,-0.054002278,0.061584435,0.025589293,0.014204781,-0.023014542,-0.021540245,-0.0072866976,-0.03346687,-0.07728365,-0.11013025,-0.061045084,0.021311197,-0.0014282843,-0.027432539,-0.07353176,0.018582983,-0.08317867,-0.009014734,0.012173218 +3.1.4.39,Also acts on acyl and choline analogues.,384,1.0,-0.09216495,-0.19100207,-0.028619016,0.06636424,-0.07046991,0.03564027,-0.01099733,0.066485606,0.014279589,-0.016377116,0.095645666,0.016404765,-0.087920085,0.059762046,0.02652133,0.15266274,-0.022473406,0.038050994,0.0059599904,-0.03578668,-0.013535167,-0.0027972802,-0.0115880435,0.009001692,-0.047228616,-0.059053045,0.0037471512,-0.006423188,0.008220811,-0.088792935,-0.020159854,0.01286107,0.036903467,-0.041283034,-0.016800975,-0.029068457,-0.012818528,-0.0030068546,0.044594865,0.016380604,0.03400676,-0.051218968,-0.028662708,-0.01556016,0.04069108,-0.07946986,-0.019330699,-0.0039440463,0.025346983,0.09299062,-0.05361983,0.0015041326,-0.02712901,0.060130764,-0.060422603,0.057690244,-0.09978288,-0.05426057,0.034312673,-0.037797503,-0.04079362,-0.0029488166,-0.013555483,0.022457115,-0.04496521,0.013109856,0.015032752,-0.03803211,0.08588031,-0.018546226,-0.0028089427,-0.121089846,-0.0039818147,0.026947122,0.02737116,0.006636476,-0.032461338,-0.088123076,0.06568195,-0.0041522,-0.063984014,0.008799913,0.014514783,0.04612929,0.08719714,0.016551953,0.007685096,-0.028341949,-0.094734415,-0.0058650454,0.039183587,-0.04836346,-0.026554024,0.04017663,-0.0533479,-0.0496281,0.054147605,0.0315159,-0.035630893,-0.0107937455,-0.016613051,-0.006136089,-0.03683281,-0.059868578,-0.05047685,-0.017076066,0.05356314,-0.03432838,-0.012617426,-0.00056751684,-0.060568858,-0.06580688,0.032506872,-0.04043237,-0.024265021,0.08932755,-0.022759456,0.03805288,0.05518135,-0.001138309,0.015154008,-0.010810502,-0.043236736,0.08386465,0.0028385927,0.037117437,-0.025753459,-2.1817801e-33,0.025015322,0.03331333,0.022164293,0.0024958798,0.07087305,-0.046913672,-0.115783714,-0.017189153,0.02914219,-0.014353914,0.004576113,-0.03078872,0.023925588,0.063730836,-0.04290595,0.00066074793,-0.033606075,-0.020070255,0.03513832,-0.023365693,-0.0112549,0.12608093,-0.027727896,0.011283324,-0.012027386,-0.016142717,-0.025853885,0.042002928,-0.018855263,0.016115805,0.038379043,-0.03269498,-0.0030674601,0.032340445,-0.059031915,0.13374087,-0.065648325,-0.08346713,-0.033429857,0.095308214,0.05137573,0.021084512,-0.07795693,-0.03107156,0.030791178,-0.046108056,-0.08845659,0.06691118,-0.018075189,0.027152898,0.06967611,0.0035785146,0.0448384,0.051513154,0.014778189,0.0038248184,-0.07000919,-0.031553756,0.05364943,0.022548636,0.03906119,0.0031362,-0.002571082,0.002184481,-0.0171449,0.04409909,-0.072659306,-0.07650152,-0.08468499,0.0265688,-0.0652413,-0.025919765,0.042090505,0.040648352,0.013376243,-0.02983791,-0.031621005,0.033791594,-0.0018255431,0.018203469,-0.046008654,-0.0461261,0.08467051,0.039584946,-0.019660883,-0.08040042,-0.031569492,-0.047202338,0.020549275,-0.035169203,0.023265025,-0.01198204,-0.067040175,0.031633534,0.0013199865,-3.6757986e-34,-0.0077449325,-0.07769063,-0.015030697,0.015081975,-0.07426277,0.10351325,0.012119407,-0.004127874,0.09142488,-0.01519374,0.05801322,0.042047825,-0.035459094,-0.09341991,0.07315408,0.03407698,0.057242233,0.065698184,-0.01492402,0.003625741,-0.06316718,0.07313107,0.039186627,0.06720358,0.044402234,0.03046349,-0.0111326,-0.023573473,0.03519578,0.05153998,0.013916885,0.00015086052,-0.06326567,-0.09988094,-0.04500363,0.041816726,-0.0017678638,0.047789507,-0.055187404,-0.005643647,0.024144992,-0.035397146,0.12045225,0.061175585,0.040160917,0.05391429,0.023332236,-0.0013981955,-0.07451356,-0.033849526,0.009690531,-0.019977877,-0.025256352,-0.031643637,0.062897936,0.13679382,0.018949466,-0.12077697,-0.000714152,-0.07207251,-0.06527587,0.013673957,-0.010389735,-0.06417345,0.026336543,0.035034087,-0.008540249,-0.010520439,0.08294055,-0.07575809,0.07560401,0.10563277,-0.055566043,0.029457122,-0.06704128,-0.018080711,0.013044598,-0.089089766,-0.020967823,-0.033778407,-0.050883643,-0.030026522,0.04174208,-0.0021719162,-0.04384041,0.063179106,-0.080566436,0.0663607,0.066971645,0.071329854,-0.018297665,-0.0059399963,-0.08254806,0.04281767,0.03118976,-1.6544666e-08,0.07977852,0.0051544094,0.09293068,-0.04247147,-0.06649011,0.027270164,0.025379278,0.03735118,-0.007290278,-0.017044736,-0.043891244,0.16043663,0.07891348,0.029229483,0.027165605,0.060242936,0.021144126,0.040454276,-0.070841536,-0.024766408,-0.11649215,0.0025886972,0.050013475,0.068870366,-0.024214575,-0.0568048,0.06356894,0.04702591,-0.0011478845,-0.047307502,0.05826749,-0.008676515,0.0036600607,-0.03905155,-0.0030824104,-0.014267683,0.07076119,-0.115063325,-0.019728908,0.07804759,0.016443113,-0.037090223,0.018822134,0.036345057,0.046281576,-0.051456157,-0.0055017103,-0.038399275,-0.010250319,0.030773506,0.00928146,0.015547407,-0.018602291,-0.026676605,-0.07412533,0.034955874,-0.027958835,-0.058547862,0.054768585,-0.05989592,0.020147001,-0.004704666,0.1522268,0.004445985 +3.1.4.41,"Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.",384,1.0,0.037688978,-0.15580826,0.049734425,-0.031244405,0.0012546667,-0.029314302,-0.022009747,0.0059891012,-0.022970729,0.008959889,0.026164839,0.002023793,-0.026410408,0.05938842,-0.012225177,0.12937613,-0.044093147,-0.023825346,0.0013369984,0.039119706,0.037562367,-0.017430292,-0.0063736686,0.020149637,-0.08403257,0.02279778,-0.016241966,-0.018601399,-0.009396087,-0.06115527,-0.04154466,-0.024812698,-0.006820878,-0.059812356,-0.013451366,0.023852142,-0.009535267,0.019823244,0.0060929833,0.021407623,0.07327481,-0.03678554,-0.016753914,-0.031776197,0.0027022013,0.0040318454,-0.020781152,-0.0082708495,-0.040741377,0.046761233,-0.026259582,-0.08022663,-0.08280795,0.0630734,-0.10399127,0.11441275,-0.103280395,0.08819886,0.045057714,0.015134267,-0.12657113,0.048175443,0.045771103,0.045486707,0.05856397,0.010084878,-0.004984846,-0.051425654,0.06735136,-0.00048146627,-0.027952984,-0.07641861,0.051732875,0.028460959,0.05391843,0.08404797,0.024876064,-0.011594419,0.06263241,-0.15568079,-0.024944875,-0.09308955,-0.01415286,0.051344384,0.024505828,-0.0023217022,-0.06303652,-0.059224844,0.014221653,0.01232657,0.010157127,-0.10606787,-0.006890135,0.013003656,-0.048508883,-0.0021460324,-0.0011741929,0.042281285,-0.047931857,-0.055152472,0.0052652783,-0.0026528449,-0.07420659,-0.039490327,0.04582324,0.043651544,0.020386763,-0.098979555,-0.038549487,-0.04672967,-0.012805627,0.00037874337,0.08837452,-0.04174892,0.06107057,0.051290028,0.0071933544,0.007704281,0.025954306,-0.028701738,0.02778369,-0.052477,-0.005018381,-0.05672473,-0.07819895,0.042001203,-0.025770292,4.969253e-33,0.021729901,-0.038070407,0.011264052,-0.06653903,0.0075126234,-0.03179426,-0.048837285,-0.020334817,-0.0020954087,0.013309316,0.015518462,-0.05272642,0.0499637,0.06263397,-0.026417568,0.0362732,0.041773,0.012887958,0.05296971,-0.012435803,-0.016826265,0.043979023,-0.055510145,-0.00034035137,0.054492705,-0.05643795,-0.025756821,0.009824196,0.02854142,0.030706283,0.046111755,-0.11706484,-0.10693208,-0.009152767,-0.042565122,0.08100811,0.027143922,-0.04378938,0.02004699,-0.021417229,0.008757951,-0.031414855,-0.047423836,0.012265098,-0.021005757,-0.055465393,-0.03750955,0.086392626,0.04097689,-0.03914386,0.030112525,-0.08992865,0.085623175,0.011592662,0.031884402,0.018642697,0.023378061,-0.023106938,0.046600357,0.008205406,0.053927213,0.03854927,-0.09469582,-0.019172275,0.04949868,0.036961965,0.005158032,-0.078682646,-0.091343805,-0.001014695,-0.036571324,-0.005182264,-0.023160864,0.066407114,-0.0015118895,-0.10001549,0.05375871,0.02046457,-0.0046734028,0.05578738,0.10048352,-0.007901224,0.041979462,0.08483076,-0.010955268,0.031488758,0.034831017,-0.010851412,-0.056538142,0.005028419,0.027167903,-0.0365743,0.013417723,0.031460166,-0.0029377607,-6.532908e-33,-0.057909727,0.0055652657,0.048228342,0.02494781,-0.024106601,0.090922646,0.017549725,-0.0032763388,0.10500424,-0.039933067,0.06345754,-0.026254434,-0.024188424,-0.010975418,0.028636448,0.022575077,-0.06791142,0.010783725,0.075239874,-0.04726621,-0.04047168,0.027076064,0.005756833,0.15642494,0.043529388,-0.05252991,-0.031084463,0.048041,-0.027239162,0.07557172,-0.03840976,0.020616919,-0.04931611,-0.083696984,-0.049249623,0.016458888,-0.030423565,-0.036063697,-0.07271342,-0.044086102,-0.013734446,-0.01725706,0.18762925,-0.0112568205,0.009158823,0.07191152,-0.024066903,0.026942056,-0.066290185,0.07212101,-0.045051847,0.017447878,-0.051136468,0.056275476,0.07010291,0.112646446,-0.055334818,0.010044003,-0.011370653,-0.14621827,-0.05424579,-0.04462568,-0.079751015,-0.0047640954,0.08083283,0.08082331,0.006774409,-0.018770618,0.03356565,-0.048676614,0.07043859,0.03959367,0.025255734,-0.01491085,0.004031884,0.04537225,-0.024428533,-0.079444386,0.015432432,-0.03923256,0.08313394,0.07420524,0.083776765,-0.055697214,0.048836403,0.021515993,-0.077594884,0.091040574,0.010973123,0.007396378,0.03923708,-0.036578596,-0.046565108,-0.05288354,0.03746907,-3.2835516e-08,0.08822833,0.017076494,0.04715219,-0.044618674,-0.045062702,-0.027406026,0.03032955,-0.009007059,-0.04183722,-0.013332995,-0.054373834,0.08495091,0.0030325183,-0.0037224158,0.049108624,0.018118318,-0.011165648,0.11559161,-0.045910135,-0.022229938,-0.009908627,-0.014641329,-0.02183496,0.0716809,0.01836324,-0.006590351,0.07294809,0.0027103953,-0.00852195,-0.018980658,0.07335902,0.022180865,-0.028036531,-0.10357859,-0.025774445,-0.029915791,-0.032205988,-0.033513676,-0.034343652,0.09765822,-3.858479e-05,-0.010728502,0.0555053,0.016019285,-0.015102304,-0.017061995,0.040463064,-0.04736302,0.022366496,-0.039971538,-0.0013246408,-0.025082879,0.04000824,-0.07924259,-0.1089218,-0.02542589,-0.017819135,-0.03657868,-0.0056933337,-0.078449056,-0.02912055,0.06893978,0.12518719,-0.0050777225 +3.1.4.42,"Acts on both stereoisomers of the substrate and also, more slowly, on 3',5'-cyclic AMP and on 2',3'-cyclic AMP.",384,1.0,-0.0054989615,-0.0041084574,0.020615097,-0.07621654,-0.014437942,-0.016208148,-0.026938029,-0.02695836,0.01671299,0.011188707,0.11123588,-0.045195192,0.002785803,0.043608226,0.07118144,0.07055055,-0.066099904,0.0658954,0.06611784,-0.009874819,0.08417956,-0.03777126,0.006128427,-0.024795868,0.02570562,0.009797859,-0.030921306,0.060951818,0.015563428,-0.10747745,-0.058825053,0.030621639,0.0043995073,-0.019996129,-0.114430614,0.045538373,-0.078324094,-0.00971485,0.0057939705,0.04221375,0.03945009,-0.05829976,0.023660252,-0.07379382,-0.06149851,-0.06983091,0.007431604,-0.01490548,-0.028435525,-0.06066456,-0.03509647,-0.10479022,0.017257001,0.0473648,-0.07869801,0.04804365,-0.02808449,0.1359435,0.036761865,-0.00911047,0.0509426,-0.021369692,-0.059195876,0.02426705,0.026405504,-0.0077545866,0.041165434,-0.05178002,-0.047089268,-0.016103296,-0.037344877,-0.06274498,-0.06766655,-0.14784887,0.118218064,0.023326008,-0.020672847,0.020781526,-0.005709798,-0.083950244,-0.031590402,0.0066773305,-0.029220525,-0.07138556,-0.016933741,0.028322974,-0.03570245,-0.083486065,-0.07507839,-0.025792899,0.020154025,0.0031273728,-0.06484943,-0.029127015,0.0027717424,-0.031992033,-0.032638017,0.036456916,0.075570054,0.08185798,0.12183851,0.0067744814,-0.10099332,0.033336166,-0.030381063,-0.017125452,0.021179987,0.080668725,-0.12082834,0.01451215,-0.019399824,0.024265984,0.030829024,-0.035187613,-0.06987157,0.10802333,0.03808942,0.10254916,0.016658023,0.005856135,-0.015744964,-0.04471747,-0.04956479,0.044516727,-0.057879303,0.06596329,-0.02123261,-1.8437274e-33,0.06273634,0.012852167,-0.0056768316,-0.033560555,-0.004371175,-0.02201177,-0.08593098,0.04958188,-0.04725416,-0.041612238,0.011534597,0.06201225,0.044527635,0.023864552,-0.032456312,-0.10077273,-0.08662275,0.03208753,-0.0012438052,0.008274905,-0.021791074,0.02758851,-0.0621345,0.029775426,0.028594447,-0.03881406,0.016914934,0.002256695,-0.072379455,0.0026782795,0.012565303,0.029327288,-0.017296711,-0.06279163,0.09820993,0.043905556,-0.011845534,0.061391003,-0.0063145994,0.0020781206,-0.004945495,-0.029315494,-0.015199165,0.01632552,0.056263227,-0.02576419,0.03499907,0.06383292,0.05703369,0.017401442,0.10753014,-0.05761211,-0.023479171,0.063057296,0.04990618,0.040019363,0.0053737625,-0.018180216,-0.052997563,0.06882098,0.062364187,0.07899512,0.030242313,-0.038340766,-0.121786244,0.073796846,-0.0104657905,-0.024292668,0.036735572,-0.017249795,-0.007246128,0.07349551,0.035544112,0.040550683,0.0068518366,0.031900138,-0.024295114,-0.08731459,0.07910892,0.019113522,-0.06373863,-0.02143914,0.0012653182,-0.074856475,-0.15357785,0.010867536,0.035701845,-0.11652379,0.024392774,0.0021162005,0.013861539,0.036413565,-0.055096626,-0.00047353227,0.04241701,-1.35400685e-33,0.0830199,-0.071991116,0.06766105,-0.07413062,-0.008653677,-0.019681117,0.048187003,0.013814139,-0.03362554,0.011488673,0.11371043,0.058087166,-0.0021603808,0.0608988,0.0059316973,0.013323293,0.016182324,-0.009407609,0.048650578,0.087500885,0.07412729,0.04733473,0.058987208,0.12769043,-0.0031319705,0.025422001,0.032849573,0.049182437,0.032572784,0.05277966,-0.0064495085,-0.04326357,0.0063063367,-0.027572162,0.046977706,0.06442721,-0.06007378,0.04993698,-0.029697215,-0.0471187,-0.084023975,0.03785162,0.03929791,-0.00094688294,-0.016030371,0.035733867,0.034713443,-0.018642938,-0.11178642,-0.019434692,0.023921147,-0.01531296,-0.034125824,-0.030024633,0.0032881016,0.008389187,-0.02222562,-0.01263995,-0.030005174,0.051277556,0.006562605,0.034244828,-0.0075771376,-0.08300456,0.024748078,-0.014665303,0.014341163,-0.033566326,0.050761018,0.04616248,0.07035793,0.015863802,0.0024832957,-0.08846265,-0.114166036,-0.046232287,-0.0039840043,-0.017484302,-0.090287775,-0.002575821,0.015923612,0.018958785,0.048852514,-0.028526222,-0.11269681,-0.04497133,0.03582252,0.038078852,0.0137345875,0.10025906,0.013320329,0.010490354,0.020820385,0.019918362,-0.0008772987,-3.3525332e-08,0.07960022,-0.02096534,0.024499636,-0.062371172,-0.005866479,0.018945388,0.03960206,-0.034305796,0.042143993,-0.07797072,0.004972262,0.035679635,0.029869039,0.06294069,0.1166424,0.033703614,-0.08667914,0.040737554,-0.021277884,-0.013756742,-0.09382049,-0.020712959,0.024659025,-0.022860153,0.0030145294,-0.012744077,0.012093069,0.08318659,-0.010978866,0.002551125,-0.019568939,0.032194123,-0.10713001,-0.005921943,-0.035635356,0.023658639,-0.08856297,-0.07899351,-0.07829807,0.042082697,-0.02327833,-0.07564094,-0.030087119,0.045319002,-0.009644526,-0.04206377,0.020064753,0.008628243,-0.021394776,0.022500247,0.0065201423,-0.064057775,-0.016603967,0.027859706,-0.0056049596,-0.063453525,-0.057955153,-0.01568816,-0.017151559,-0.014340344,-0.032876868,0.035625193,0.11632322,-0.04033227 +3.1.4.43,"This enzyme also hydrolyses Ins(cyclic1,2)P to Ins-1-P",384,0.9999999,-0.036167737,-0.06707154,-0.0273563,-0.027712267,0.11988576,-0.07034624,-0.042400137,0.066453576,0.0018239642,0.006759284,0.0047823694,-0.011013413,0.04156441,0.051663563,-0.015338383,-0.0021557924,-0.10464814,0.0016027244,0.0682511,-0.023646252,0.05882478,-0.010449606,-0.029276246,0.0048504905,-0.007628299,0.046021946,0.06664202,0.05684723,-0.003615985,-0.07555552,0.0023462686,-0.03896995,-0.002021388,-0.02800102,0.032127276,0.07850537,-0.06559529,-0.0068357424,-0.08509376,-0.018833494,0.15163483,-0.036453772,0.0019575688,-0.09687321,-0.037996575,-0.066307895,-0.038443163,0.04220909,0.021304186,0.023909142,-0.00820497,-0.0395012,-0.04166991,0.049326796,-0.01677314,0.016874736,-0.06279358,0.09226749,-0.076677844,0.031834602,0.08968514,0.07840078,-0.0026517163,0.05860134,0.05352861,-0.06114954,0.09328338,-0.024522575,-0.011030222,-0.05725619,-0.08189912,-0.0730565,-0.03023842,-0.06645411,-0.011004816,-0.032406967,-0.051519256,-0.051495098,0.029750472,-0.07380105,0.048397582,-0.017959293,0.050020788,0.050064635,0.04271413,0.020777872,0.031527266,0.03646744,0.015939238,-0.012619983,0.026853234,0.027092231,-0.015954182,0.0153935775,-0.024919208,0.043281313,-0.006483859,0.03185155,-0.008626177,-0.025629302,-0.02828343,0.06266971,-0.061816312,-0.05883547,-0.06506381,-0.016846599,-0.0065380684,0.038607396,0.062348623,0.031346012,-0.067408666,-0.012038547,0.0534481,-0.029211339,0.00037626253,0.08804838,-0.018153507,0.07215314,0.061450876,0.0053765024,0.0032272134,-0.042045992,0.04857129,0.09282767,-0.04174065,0.041168913,-0.04782718,-3.2341273e-33,-0.011391277,0.010956193,0.020933533,-0.038746506,-0.054348312,0.035536353,-0.07358294,0.038474962,-0.07515912,-0.044070784,-0.049223162,-0.07278316,0.05691724,-0.011822495,-0.010220531,-0.063441515,0.01001367,0.011777674,0.06505187,0.03265828,0.01783249,-0.008284936,-0.07035159,0.022719067,0.054320868,0.004795166,0.042435016,0.02102195,0.06636537,-0.0057573775,0.016018061,-0.06132332,-0.11205982,0.0103973,0.06937356,-0.0007323744,-0.036334805,0.030918501,0.03678625,0.07364971,-0.06858745,-0.09512714,0.09173671,-0.10830851,0.04913929,-0.08950979,-0.05372308,0.09364148,0.021088652,-0.012327914,0.07117027,0.010006542,0.026295213,0.017225996,-0.07833786,0.020172045,0.012001764,-0.008467965,0.019159392,0.027151741,0.0064564073,0.035387352,-0.018529868,-0.030040845,-0.012876363,0.033685442,-0.089453265,-0.015191813,0.045387544,0.111841254,-0.15246625,0.02519383,0.043185744,-0.013378318,0.043101024,0.006613013,0.03400162,0.010579378,0.045619648,0.09091335,-0.021430548,-0.04822225,0.09891435,-0.0147054605,-0.0340972,-0.08398919,-0.036971,-0.0016969349,-0.026694912,0.03772736,0.1236725,-0.056381814,-0.014162599,0.033681482,0.0037306733,1.1638435e-34,0.0716666,-0.039569236,0.08010417,-0.105182074,-0.02331644,0.020471275,0.03745128,-0.021511987,0.053561572,0.02431673,0.10119823,0.013106894,-0.06378075,-0.04117208,0.009786725,0.007694436,-0.038212966,0.071147546,0.038301125,0.025068734,0.023179978,0.057415217,0.022728,0.030512553,0.0052640005,0.012418059,0.007968159,0.052512564,0.096626155,0.10697196,-0.059521176,0.012342209,-0.0393368,0.0128466375,-0.04591687,0.019373614,-0.08078909,-0.05961169,-0.002703096,0.08631465,-0.039361767,0.01988501,0.019343792,0.013999144,0.04769016,0.05943712,0.028145835,-0.021590536,-0.049682572,-0.03716635,-0.009502673,0.088654086,-0.03821492,0.042601053,0.03148515,-0.041700143,-0.014823796,0.06451172,-0.05760422,-0.03909097,-0.029566683,-0.032067344,0.03222757,-0.0026704834,-0.044207815,0.0027636485,-0.01924279,0.023847416,-0.00035327245,-0.0071490034,0.06039139,0.021706196,0.04978598,0.01693123,0.00063486863,-0.04556079,-0.029810997,-0.05979993,-0.040813353,-0.10587548,0.013619791,0.014469941,-0.086269505,-0.10988358,-0.031909388,-0.11064489,0.024731465,0.09735898,0.009829167,0.027663521,-0.01506913,0.0668546,-0.016606014,0.060633175,0.059124846,-2.3204526e-08,-0.018948028,-0.09500743,0.076875865,-0.02456967,0.007803847,0.012741082,-0.009013936,-0.03424037,0.056139074,-0.095593445,-0.05377249,0.08572251,0.026184525,-0.025747515,0.05176844,0.038080946,-0.0013396431,0.006394914,-0.01806362,-0.015723752,-0.02885219,-0.04561155,-0.16779713,-0.013961867,-0.0067857285,-0.030102307,-0.022333961,0.020257378,0.025781017,-0.070114575,-0.045415655,0.006177956,0.0058336323,-0.05536477,-0.06868765,0.07009419,-0.015307241,-0.017322756,-0.08373065,-0.032946303,0.07686572,-0.041705046,-0.028073728,-0.01964828,0.060714263,0.01723415,0.032778747,-0.030918075,-0.00632444,-0.030278305,4.4282868e-05,-0.0045516076,-0.043717936,-0.051928718,-0.0138875395,0.048922434,-0.019238684,-0.06561183,-0.033306614,-0.043751735,-0.069373034,0.017594604,0.18380572,-0.026509961 +3.1.4.45,"Acts on a variety of compounds in which N-acetyl-D-glucosamine is alpha-linked to a phosphate group, including the biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes and the products of EC 2.7.8.17 UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase.",384,0.99999994,-0.016252637,-0.09135016,-0.06128232,-0.07251379,0.02352435,0.008189707,-0.0063094236,-0.020084517,0.008184853,0.11399832,0.018489173,0.047472205,-0.02818451,-0.014087909,-0.07908637,0.0038730933,-0.05430075,-0.013833407,-0.04376266,-0.03641165,0.10817642,0.033567633,0.025894247,-0.024459578,0.045438636,-0.016832676,0.05718706,-0.029433757,-0.008611348,-0.1345883,-0.04675067,-0.027641475,0.025785238,-0.054743998,0.09092795,0.087319896,0.012957729,0.019118328,0.059764486,-0.01831521,0.016444629,-0.087247945,-0.0043563764,0.0076815053,-0.07352459,-0.035881884,-0.042993452,0.07270694,0.010750017,0.019346226,0.0012729198,-0.059108973,-0.020326808,0.028821873,0.023116795,0.038770884,-0.08821317,-0.004010463,-0.0029457656,0.06927145,0.037262123,0.06177773,-0.00070261874,-0.023394424,0.03735204,-0.06742387,0.12710771,-0.100966305,-0.04992513,0.017671995,-0.0051905257,-0.05481296,0.033710085,0.00037421126,0.06827325,0.013415299,-0.032203596,-0.019247264,0.016417872,-0.024304695,0.059804264,-0.00043192963,0.030771451,0.07789183,-0.015391108,-0.05198847,-0.05130338,0.039265513,0.055534333,0.013336322,-0.035804287,-0.087831825,0.08605382,-0.022734609,-0.042510837,-0.06722123,0.020876126,0.054277584,0.025052069,-0.009384171,0.0026719498,0.059945956,0.009936729,-0.086296305,-0.04450114,0.02498448,-0.0055438867,0.055114258,0.030261617,-0.015134551,-0.02626159,0.049588446,-0.00930121,0.025515351,-0.14399159,0.04433153,0.001962929,-0.0882176,-0.028789023,-0.031144833,0.06595705,0.021282462,0.07175782,0.08070445,-0.047309656,0.03704862,-0.027008701,3.2764565e-33,0.056679882,0.048998248,0.05143501,-0.023518626,0.007106947,0.0035960607,-0.07199422,-0.055256024,-0.042238176,-0.007443472,-0.0755988,-0.03399136,0.06989636,0.087249264,-0.016093105,0.07251816,-0.03584082,-0.022637067,0.054253887,0.0028190762,-0.0149802435,0.085955456,-0.0754498,0.053970065,0.022761429,0.034627125,-0.08080244,0.05125095,0.043725133,0.026482342,0.042003155,-0.0649229,-0.06548582,0.028726129,-0.009639976,0.0026090934,-0.043535646,-0.048598163,0.083456896,-0.033950847,0.0084755905,0.03778404,0.00869659,-0.020079719,-0.014236993,-0.016214926,-0.025920259,0.020259116,-0.03601756,0.101928376,0.024210854,-0.07802667,0.051812734,0.0036307564,-0.042982303,0.037244786,-0.059667803,-0.057125296,0.055274572,0.11109179,0.025542796,0.023673069,0.007907539,-0.054326933,-0.02296294,-0.031046435,-0.04718162,-0.06965307,-0.018376995,0.0034114334,-0.043207336,-0.074230894,0.07640129,0.046743296,0.0150557,-0.04140679,-0.020575631,0.030821206,-0.021717751,0.01985071,0.054183774,-0.020300662,-0.057486188,-0.03883086,-0.06457417,0.039354462,-0.009153762,-0.085954905,-0.025937391,0.039141584,-0.059729934,-0.078535244,-0.083431125,0.0589864,0.012012345,-5.8454226e-33,0.12012708,-0.03633182,0.08816046,-0.022530535,-0.061968964,-0.00132569,0.091766044,-0.06005899,0.022992192,0.016508086,0.065247394,-0.024173776,-0.009373795,-0.004104481,0.045142412,-0.041490797,0.0033687812,0.07911059,0.03392804,0.06126436,-0.030659001,0.087834455,-0.007991122,0.026238894,0.07122319,-0.05020402,-0.04094823,0.060743064,0.0023170416,0.06877324,-0.028784744,-0.018139312,-0.038408075,-0.03701691,-0.03370168,0.0031175085,0.023440491,0.0012362617,-0.07404206,-0.026947586,-0.023276214,0.05358832,0.040631488,-0.0127872685,0.069158964,0.07027454,-0.055795263,0.02327742,-0.11191631,0.010508958,0.019730125,0.03522396,0.017027218,0.020408899,0.017416853,0.06222876,0.019391278,0.054732416,0.027044922,-0.032567438,-0.019780405,-0.021021552,-0.018236423,-0.030932987,0.091037475,-0.003425706,-0.05388559,0.054596964,0.03611779,0.036102727,-0.06173844,-0.029224483,0.06096281,0.034645665,-0.014506285,-0.062365472,-0.14830217,-0.09228851,-0.006240547,-0.08018615,0.00045895722,-0.040647514,0.028526386,-0.011373261,-0.026310442,-0.0032936009,0.07984055,0.11987831,0.0072557395,0.06054215,-0.03927814,-0.04697474,-0.083172284,0.05677904,0.0795696,-4.5005066e-08,0.091212414,-0.003043368,0.01684135,-0.06143856,0.019714737,-0.03010659,-0.019950729,0.07500477,0.06271019,0.0057713795,-0.036374632,0.15078628,0.050575823,0.002469134,-0.06189069,0.05423301,0.010584381,0.034030702,-0.014617485,0.0017440971,-0.07976963,0.0020854387,-0.06908735,0.031829026,-0.00024139747,-0.04777051,0.060497828,0.022239098,-0.04355121,-0.034134164,0.006550217,0.023849268,-0.012683791,-0.14410208,-0.026018472,0.01000082,-0.049935136,-0.070770025,0.06821481,-0.006455443,-0.019157443,0.016733821,-0.028320033,0.032015804,0.014077048,0.0028990302,-0.0032019145,-0.008672201,-0.022347644,0.030234322,0.007930277,-0.026785292,-0.09735241,-0.10557247,-0.050089873,-0.046422083,-0.042496577,-0.028474914,0.06538316,-0.061344292,0.02828336,0.011418476,0.11636293,-0.10298228 +3.1.4.46,"Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis(glycerophospho)-glycerol are hydrolysed.",384,1.0,0.04802945,-0.067944705,0.019870775,-0.06056312,0.0032958635,-0.020061571,0.010363279,0.0383261,-0.0554924,-0.05075565,-0.03435837,-0.035643507,-0.04888698,0.039504513,-0.016941212,0.040998187,0.011927244,-0.012554184,-0.028260518,0.007472583,0.02267271,-0.024320783,-0.03129854,0.03920273,-0.049537893,0.038646515,-0.020875612,0.0018349779,0.047968127,-0.024322057,-0.05530361,-0.010726644,0.04692638,-0.037081156,0.0039462512,0.0589943,-0.048061647,0.052059766,-0.08335351,0.061651673,0.088297956,-0.029217156,-0.019655384,-0.043255337,-0.0122275725,0.010252327,0.025308428,0.03598313,-0.069376156,0.08426998,0.040338058,-0.09281268,-0.094993345,0.03826367,-0.011953345,-0.027499817,-0.06868728,0.052841377,-0.0034489085,0.045605425,-0.013733341,0.05871912,-0.0089138895,0.018305633,-0.030406266,-0.025173912,0.07650692,-0.026264299,0.102343574,0.03749087,0.006289984,-0.044430025,0.07936388,0.0033828542,0.013215206,0.025059499,0.0050330157,-0.035005827,0.06668964,-0.11013644,0.0014456527,-0.07660321,-0.010209486,0.042730626,-0.012930212,0.03165385,-0.03666135,-0.0010747686,-0.033544768,-0.05995331,0.040664267,-0.07119875,-0.02150235,-0.063388154,0.009882921,-0.009783661,-0.004710314,-0.05019116,0.014364459,-0.03927311,-0.0078307325,-0.0026669162,-0.022413759,-0.075333856,0.027992958,0.056928925,-0.035092905,0.015055983,0.038526837,0.0055353055,-0.03310842,0.016016187,0.100213245,-0.013592879,-0.008267075,0.023994096,-0.052451007,-0.01001136,0.0863107,0.012842974,0.036914717,-0.01881088,0.042295378,-0.015595609,0.012281022,0.14215201,-0.032767717,9.403955e-33,0.051172994,0.030792728,0.041835915,-0.015118991,-0.065133885,0.02603204,-0.020189466,-0.015954854,-0.039099637,0.03906454,0.027810555,0.07190746,0.017484514,0.15545307,0.035962198,0.030024644,0.011408702,0.01797317,0.054335944,-0.106659286,0.025470847,0.05046955,-0.047939524,0.020717751,0.05408368,-0.004722608,0.010441259,0.08698775,-0.012305875,-0.031948496,0.04299693,-0.092006594,-0.076929845,0.034131438,0.045069106,0.05146603,-0.028119517,-0.021173008,-0.00018950131,-0.016594067,-0.011546857,-0.044622224,0.034221802,-0.013400202,0.09450495,0.029518384,-0.17204864,-0.04942155,0.048899367,-0.024360433,0.039221134,-0.035080574,0.043475002,0.026787562,-0.033675008,0.010282126,0.029607136,0.044510122,0.002016022,-0.0049825385,-0.08046111,0.10646776,-0.04670446,-0.10564496,0.035276603,0.038999766,-0.05367135,-0.06003965,-0.058912776,-0.062273853,0.015357305,0.0026126204,0.070052244,0.042515635,-0.033669665,-0.041988708,0.028960982,0.029779343,-0.036719054,0.04857762,-0.0016718975,0.056075186,-0.016842073,0.06074321,-0.12575282,0.013556677,0.0734135,-0.09812874,-0.06733527,0.028519,-0.063081436,0.052971426,-0.017000938,-0.0046128784,-0.08928416,-9.5789624e-33,0.037395358,-0.031229708,0.051273964,0.024975648,-0.025436984,-0.0021848013,0.070843,-0.02878581,0.053989816,-0.08770051,0.033435643,0.0076321512,-0.011769222,-0.013508391,-0.021079006,0.038347624,-0.0205937,0.034088545,0.044470236,0.03606598,0.0063072066,0.012680189,0.0014421471,0.071696885,0.10496993,-0.07897691,0.06057858,-0.025262984,0.012931152,0.05045872,0.014915113,0.026475007,-0.03872343,-0.10265229,-0.037701845,-0.048108302,-0.06730574,-0.016834117,0.009333904,-0.041646387,-0.040771782,0.03520498,0.09574606,0.011277273,0.08876411,0.07028845,-0.033959974,-0.03244819,-0.05515292,0.07006125,-0.048388477,-0.08037957,-0.05351316,0.0531905,0.024803024,0.022925105,-0.016388606,-0.0010607705,-0.01404136,-0.07570537,-0.027069064,-0.0052272384,0.0108239995,-0.0025194795,0.020472065,0.16050921,0.017042443,-0.085903704,0.04219143,0.016301924,-0.006199933,-0.06699621,0.027127044,0.047794458,0.047747772,0.019556269,-0.015845295,-0.007899273,-0.009404017,-0.065903574,0.09035028,0.06880286,-0.0042441497,0.01937819,0.03302148,-0.031519752,-0.035856787,0.11209473,0.05876926,0.060374923,0.023239179,0.00073076144,-0.029301507,-0.08213839,0.047781043,-4.118682e-08,0.0686292,-0.05996527,0.009774557,-0.104303375,-0.025628442,0.0218473,0.07648111,-0.046827633,-0.0018596692,-0.009461232,-0.028101454,0.03695982,-0.040163476,-0.08708614,0.0199569,-0.0043870425,-0.07650135,0.06025297,-0.04826239,-0.039281525,-0.055410467,0.016402526,-0.09478251,0.080135874,0.03284599,-0.009832922,0.040407285,-0.08131274,-0.019639123,0.069277085,-0.019203236,0.039507553,-0.014480996,-0.039217222,0.112649314,0.055578563,-0.04675304,0.030101933,-0.07548552,0.04001529,-0.027862033,-0.027598646,0.018832179,-0.030937674,0.059494197,-0.11776775,0.003872467,0.05152194,0.047540843,0.015183512,-0.02154435,-0.022874912,0.024961205,-0.12667763,-0.14747526,-0.03153303,-0.04202565,-0.07056491,-0.030637294,-0.03559351,-0.012747327,-0.0054944004,0.14928412,0.0015512026 +3.1.4.50,"This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes.",384,1.0,-0.012105863,-0.0736748,-0.07062052,-0.02656513,0.051447753,-0.04236729,0.019247424,0.015490153,0.05393023,-0.0066333697,-0.0021656589,0.103546694,-0.033393037,0.07332801,-0.023889868,0.022182465,0.018660432,-0.077963896,-0.07134738,-0.012778309,0.118475944,-0.028761134,-0.058058962,-0.024345156,-0.009382751,-0.08223065,0.0567483,-0.040631995,-0.003180314,-0.024679255,-0.044111677,-0.027643232,0.02501677,-0.0555933,0.026604135,0.087536566,-0.038949978,-0.04290497,0.0013510094,0.063324526,0.026186032,-0.06078434,-0.058304485,-0.038292486,-0.025173081,-0.057730034,-0.023820415,0.006938344,0.047732454,0.039371926,0.002970762,-0.04326975,-0.0038814605,0.03334152,-0.023256436,0.06370627,-0.12965025,0.0031615864,-0.028295714,0.07686142,-0.022094041,0.07659535,0.0009673612,0.047055237,-0.0032645536,-0.09861991,0.09105939,-0.089149006,0.008567076,-0.01577797,-0.0007307144,-0.022667507,0.012725783,-0.019090757,0.031096654,-0.027448397,-0.032167833,0.0018452634,0.05785713,-0.018315982,0.057973005,0.0008453851,0.08456232,0.10034567,-0.025305878,0.01363183,-0.011241424,-0.011323637,0.0231263,-0.014313165,0.02453084,-0.06251476,-0.040471185,0.012574339,-0.027255906,-0.065615684,0.0347566,-0.049918003,0.010490008,-0.027496662,-0.026362523,-0.027206508,0.011355615,-0.024749385,-0.0625506,0.05318453,0.03408335,0.06775107,-0.021583496,-0.011117678,0.03219043,0.055004675,0.08121043,0.011644553,-0.07634253,0.048795853,0.026747506,-0.013944784,-0.04560717,0.0037287686,0.007833255,0.0026660205,0.0674755,0.07102443,-0.06515826,0.08753991,0.0001941737,4.3888885e-33,0.05603763,-0.0029267573,0.016019208,-0.102936015,-0.036330476,-0.006827183,-0.025693849,0.0048995367,-0.01534967,-0.0035700183,-0.026167743,0.0049023647,0.019943122,0.112581775,0.023039082,0.035077333,0.00926458,0.016519208,0.083662905,0.016453557,0.07654761,0.0908385,-0.007517653,-0.04204561,0.0062872055,0.06310714,-0.068190776,-0.024543598,0.03539402,0.0085133845,0.029229188,-0.09517689,-0.08186265,0.059433177,0.0017214795,0.053406715,-0.06265354,-0.066976726,0.00806095,-0.012590671,-0.023774276,-0.0017179612,-0.011697363,-0.08860789,0.017984213,-0.032168586,-0.08600122,0.05576522,-0.0020666511,0.052935608,0.0548303,-0.02382381,0.06459735,0.020115327,-0.10122666,0.025431588,-0.034777083,-0.106599584,0.038551487,0.07804615,0.031253193,0.045245692,-0.036734678,-0.02560272,0.03259331,0.026774203,-0.07548528,-0.09036052,-0.02939493,0.03840397,-0.041620288,-0.026519382,-0.003261552,0.0641646,0.017540265,-0.09996918,-0.018205121,0.05803918,-0.0027212917,0.05880187,0.046389684,-0.021307651,0.068792254,0.030765122,-0.062098026,0.008690608,0.01899341,-0.07922191,-0.0291487,0.007909979,-0.049278826,-0.066338815,-0.030625915,0.07065656,-0.0018717723,-7.721933e-33,0.14190583,-0.122057095,0.105657384,-0.043928485,-0.039033923,0.05416099,0.030706247,-0.012515017,0.045563858,-0.009411606,0.022421591,0.05266254,-0.047966037,0.037845444,-0.0014489499,0.02758301,-0.11383304,0.017354822,-0.08184231,-0.022334082,-0.052355282,0.055877328,0.04896308,0.04892802,0.11122763,-0.103845134,0.024324212,-0.009113316,-0.07949916,0.055205163,0.014487854,-0.0030106632,-0.07261859,-0.06183118,-0.005136792,0.0705398,-0.061180405,-0.027347857,0.0031775401,-0.009280251,0.009997812,0.010524854,0.09782354,-0.027808284,0.018900983,0.079323165,-0.1200526,0.022769978,-0.06659322,-0.03933528,-0.008779533,0.033080462,0.02396673,0.031544127,0.06708485,0.07063381,0.059099607,-0.018956732,-0.06096011,-0.05866095,-0.043536488,-0.019204158,0.00022495679,0.013374597,0.050724752,0.052358273,0.023296075,-0.009567398,0.036230333,-0.026501779,0.033257913,-0.042292867,0.02525283,0.051475327,-0.042043794,0.033856414,-0.053787176,-0.082691155,0.006265521,-0.05487229,0.047680665,-0.04585391,0.03590111,-0.116774626,-0.010091399,-0.049325947,0.054177772,0.06346605,0.0074353297,0.04792537,0.028205676,-0.047618113,-0.036934935,-0.011402052,0.07201223,-4.7611252e-08,0.057726905,0.00037194687,-0.004274149,-0.09578947,-0.12613611,0.0017898169,0.10488055,0.028522842,0.004089098,-0.022942754,-0.0039601945,0.07427312,-0.018814402,-0.031575333,-0.0034777538,0.056681488,-0.028656533,0.039389946,-0.005184394,-0.0572628,-0.07573941,-0.05043336,-0.09865478,0.06294667,0.022237731,-0.05346339,0.04773054,0.0536803,-0.007201087,0.004004917,0.007193463,0.060971074,-0.05270386,-0.0054689846,-0.0063610454,0.026912779,-0.027426988,-0.02833629,-0.04370779,0.05741401,0.022572778,0.028781954,0.014672028,-0.068758294,0.031522904,0.010027662,0.00026949155,0.003747167,-0.002179166,0.06429325,0.0042897915,-0.024822606,-0.02510062,-0.051886745,-0.091184065,-0.061487723,-0.088185966,-0.06328761,-0.005519783,-0.05315104,-0.01291902,0.043420114,0.19778301,-0.0591127 +3.1.4.51,The enzyme is specific for the product of EC 2.7.8.19 UDP-glucose---glycoprotein glucose phosphotransferase.,384,1.0,-0.06738424,0.008966904,-0.050174184,0.007844107,0.046825964,0.036136985,-0.022245025,0.08511294,-0.005127601,-0.026040472,0.046380907,-0.013838099,-0.11446895,-0.00023931623,-0.03442276,-0.01690827,-0.026467944,-0.019949216,-0.0041043344,-0.052678503,0.11632378,0.03527807,0.023562206,0.016705168,0.04782075,-0.018410074,0.06568635,-0.020328779,-0.03099254,-0.07898301,-0.01834712,-0.09018369,0.052741144,-0.004852274,0.047064934,0.1276816,-0.0005029257,-0.13490759,-0.0290646,-0.011387684,0.09752051,-0.032424964,-0.023311384,-0.057241987,-0.011587002,-0.0061924136,-0.0077475277,0.04104188,0.018564673,0.061074905,-0.031095913,-0.0578838,-0.028321352,0.016286673,0.041917507,0.044328492,-0.08969559,0.013538399,0.007814932,0.009104372,0.0017533746,0.026307272,0.0466128,0.045701094,0.00196161,-0.07908862,0.10582066,-0.13202642,-0.08297014,-0.0041826568,-0.07457744,-0.08792538,0.013395602,0.039814238,0.044515613,0.028633956,-0.061808098,-0.01985553,0.04716882,-0.054950558,0.0685899,-0.0615605,-0.005292654,0.02395244,-0.042043865,-0.02608286,0.050760027,0.021958357,0.00051075127,0.012202232,-0.016140964,-0.06679877,0.019586604,0.01713898,-0.035052683,0.018437788,0.0036896872,0.041298732,0.022675045,-0.032733113,-0.008170115,0.08539036,0.007424879,-0.06870455,-0.03849921,-0.020649692,-0.04097668,0.041031156,0.0321494,-0.0076334565,0.02112465,0.04468112,0.05479499,0.0048575993,-0.041178666,0.088791735,-0.048993792,-0.069551565,0.018961215,0.051956292,0.05809881,-0.0519464,0.07841441,0.053544987,-0.06913809,0.089854464,-0.09295486,-1.42469465e-33,0.042232502,-0.025315499,0.035068847,-0.042990915,-0.014794303,0.014660234,-0.072252035,0.038488965,-0.042870518,-0.05853927,-0.08424573,-0.0531868,0.05231732,0.08362776,0.011776862,-0.011229531,0.038632397,-0.012005526,0.06602119,-0.018227644,0.053906564,0.04134904,-0.039041013,0.04209502,0.039286975,0.07482576,-0.079796225,0.074476875,0.08411876,0.010934486,0.004524042,-0.069209166,-0.031003393,-0.01715278,0.01970705,-0.03463672,-0.0073403534,-0.0862519,0.034558233,0.048050385,0.030082235,-0.007895587,0.0398271,-0.041815564,0.04298296,-0.0027934,-0.054455858,0.022908555,0.07865972,0.06426544,-0.005778446,-0.03729838,0.065749474,-0.032249276,0.036494307,0.011066589,-0.06963755,0.03643958,0.020175213,0.041679054,-0.016005235,0.14187929,0.002202884,-0.008559048,-0.040109165,0.02021974,-0.06506513,-0.056570455,-0.08928175,0.049618363,-0.052688506,0.02400418,0.10304995,0.035907034,0.028726483,-0.08823085,-0.015983019,-0.0009973565,0.0042532627,0.02243996,-0.07968326,0.036906548,-0.017789382,-0.031125307,-0.05521801,-0.03399403,-0.029533073,-0.01569915,-0.03175556,0.040355362,0.0032610435,0.0030341495,-0.08291023,0.043940693,-0.02694452,-2.2754434e-33,0.09062039,-0.07305291,0.05933224,-0.041851345,0.005080447,0.035744186,0.053289425,-0.05512867,0.06305675,-0.0143929515,0.076732144,0.01472036,0.06414295,-0.08666307,0.053927075,0.021640858,-0.12043675,0.03375491,-0.032924674,0.0020837497,0.0077189715,0.06479661,0.00060410134,0.06525308,0.08042823,-0.05795113,0.009592828,0.08139085,0.035639387,-0.01757517,-0.038111605,-0.02660891,-0.10913605,0.012793074,-0.0758338,-0.014330709,-0.051679593,-0.05276613,-0.0010591394,-0.038348775,0.021353005,0.078413725,-0.008328861,-0.0034209616,0.055515777,0.09313081,0.031677492,0.028972043,-0.02822931,-0.04545885,-0.04459967,0.044523753,-0.040457476,0.019200435,-0.024523703,0.07675195,-0.008895377,0.057038896,0.01704284,-0.024591386,-0.01917952,-0.09188407,0.067000866,-0.007861095,0.04635956,0.040366087,-0.023579203,0.002696887,0.06878409,0.05369191,0.06204893,-0.05818627,-0.038589064,0.027516808,-0.029716443,-0.011638402,-0.121153496,-0.015235483,0.040209208,-0.111417755,0.052658685,0.017621905,-0.0010678788,-0.022066861,0.022666005,-0.04805545,0.029288579,0.049066175,0.024695009,0.05243563,-0.07996927,-0.033471614,-0.09555508,0.009393553,0.02866423,-3.1067035e-08,0.060876694,-0.06403812,0.043238755,-0.06156654,0.05652747,0.021297202,-0.021930572,0.029188631,0.031108104,-0.009598202,-0.04086538,0.07802513,-0.013455168,-0.052642807,0.01949276,0.014210254,-0.061314277,0.089177735,0.02027556,0.03646264,-0.043255236,-0.04398664,-0.11951171,0.04629048,-0.0287741,-0.05933563,0.056196794,0.06845933,-0.062717766,-0.060825404,-0.010667282,0.013215204,0.023698747,-0.013883203,-0.056380372,-0.03193975,-0.05095168,0.022733994,-0.015501522,0.081201546,0.0217985,-0.063544355,-0.0038047424,0.013766825,-0.027845759,0.05030964,0.056181986,-0.03176612,-0.034528755,0.0004449177,0.0068001156,-0.049574267,-0.05896967,-0.105815664,-0.044142924,-0.047128286,-0.060842805,-0.07063397,-0.0058754487,-0.046409935,0.013471428,0.08010517,0.17241049,-0.0126412045 +3.1.5.1,Also acts on GTP.,384,1.0,-0.018301174,-0.09656334,0.032473367,-0.03459219,0.040081624,0.03673226,0.08400004,-0.06532729,0.007097272,-0.00039962298,0.013637258,0.06368899,-0.048516463,0.12329822,0.05861431,-0.0062413886,0.07731114,-0.043577723,0.020269956,-0.0057507674,-0.06659058,-0.086541824,0.016037643,-0.00027682408,-0.01975366,-0.097399265,-0.05868708,0.0042363903,0.03673851,-0.015056741,-0.0011090583,0.031250555,-0.011687042,0.045030225,-0.069768876,0.07973562,0.036823038,-0.009782397,-0.0684061,-0.0596622,0.075135365,0.016793992,-0.03244103,-0.0072237733,0.021197565,-0.047482736,0.037155375,-0.012417254,0.0070831203,0.022531139,0.025056455,0.020416565,0.032741867,0.03958281,-0.03689232,0.07567194,-0.010100286,-0.016836766,0.06212188,0.025510844,-0.068032,-0.0021648933,-0.06632255,0.005688223,-0.0123453,0.12245642,-0.00018707896,-0.0014254441,-0.026169103,-0.062008873,0.026926294,-0.0010031646,-0.044548094,-0.03985868,-0.009627753,-0.006602346,-0.013770366,-0.0043918486,0.01493024,-0.070666395,0.06199413,-0.048897233,-0.030836621,0.017628906,0.06729409,-0.04413328,-0.02229968,-0.06159067,-0.026983982,0.059581123,-0.05689286,0.059288412,0.051748548,0.04461182,-0.04128451,-0.027426237,0.012982596,-0.024026165,-0.026448825,0.08913805,-0.042432837,0.01070753,0.069382854,0.015857527,-0.022823438,-0.009358803,0.005751192,0.033806603,-0.011196471,-0.016533084,-0.03625907,0.01602116,0.004858167,0.0194715,0.026484305,0.07279899,-0.10328067,0.07222396,-0.0774038,-0.025479,0.06423736,0.0021283145,-0.009274437,0.041200396,-0.01815992,0.060886275,0.015142744,-4.2081434e-33,-0.013759335,-0.028050499,0.0060332757,-0.039120954,0.07876448,0.069143094,-0.008301776,0.012838586,0.007540398,-0.011793895,-0.024192559,-0.025390485,-0.017084086,0.021725874,0.004739563,0.055420365,-0.027563646,0.049793553,-0.04983105,-0.049961366,0.007315155,0.10154542,-0.034053303,-0.018453343,0.0106328465,0.07550788,-0.052055765,-0.04484176,0.103919685,0.011684907,0.030273035,-0.014723761,-0.07654239,0.11401977,0.062194142,0.09932649,-0.049181692,-0.10855301,-0.016119398,0.019134851,0.0011611116,-0.021546576,-0.08857575,-0.056723136,-0.0510307,-0.017101407,0.024499053,-0.049860626,0.079980426,0.05748194,0.04630559,0.03314718,-0.014286163,-0.007183783,-0.015144867,0.023784913,0.018383913,0.012107122,0.07384403,0.039196625,0.062051415,0.014856374,0.012495639,-0.02909501,-0.074181676,-0.025981603,-0.030025516,-0.05541516,0.06207007,0.040192984,-0.0038881875,0.025962848,0.11651868,-0.013677256,-0.0016646887,-0.06023498,-0.041568965,-0.042715706,-0.025757313,0.10556013,-0.10233626,-0.09408994,0.0265648,-0.057358555,0.030434066,0.0003974296,0.03922024,-0.113018446,-0.035765212,0.051904757,-0.115928985,0.009137239,0.021404032,0.07426463,-0.026050448,2.4873347e-33,-0.05358775,-0.06274641,0.017221855,0.034755703,0.022962715,-0.00965444,-0.012227258,-0.094906665,0.0041953865,0.01980786,0.02688712,0.04975037,0.03800355,0.0763389,0.1130097,-0.03925026,0.08172132,0.047272496,-0.07729669,-0.024642546,-0.010208219,-0.0011117146,0.024812143,0.094261326,0.007138636,0.047753025,0.03581738,0.032449353,0.029137438,-0.005595287,-0.031345382,0.10431546,-0.14610158,-0.0949095,0.026022136,0.038132925,-0.025267785,0.060126785,-0.03384579,-0.067438,0.09578419,-0.0145078655,0.026009584,0.08004041,-0.049216002,0.08754137,0.043103527,0.004451155,-0.096146606,0.02465741,-0.05782146,-0.01367003,-0.056780756,0.0015691443,0.01931095,0.08912538,0.028938575,-0.076737605,-0.069804505,-0.0719015,0.023332233,0.005457758,-0.07401566,-0.016788796,0.06054571,-0.011418966,0.013123596,-0.016316555,0.060288444,0.027003402,-0.0016194778,-0.024963886,0.017871503,-0.081521645,-0.13829881,0.0038111287,-0.021062408,-0.02585095,0.033238154,-0.1241713,0.031226287,-0.010226806,0.034465387,0.037992306,-0.07899431,0.022234473,-0.019066993,0.032361526,0.056055844,0.048466228,-0.032942243,0.023184502,-0.010836303,0.012613702,-0.084152706,-1.6564174e-08,-0.013763022,0.054533616,0.043559935,-0.049835876,0.03413104,0.06396056,-0.021126185,-0.0067098974,0.042387735,0.075083375,0.030614488,-0.06641699,0.009323529,-0.09101031,0.11917412,-0.10384298,0.041115817,0.020947194,-0.083188415,0.043284524,-0.12521115,0.0018103265,0.039707277,0.090356775,-0.0431056,-0.04110162,-0.06355046,0.027027542,0.097853765,0.069761306,0.029657764,-0.022535348,-0.017119737,-0.030518997,0.022215419,-0.005419057,0.038741555,-0.0077336426,-0.004615864,-0.019746242,0.041262902,-0.084891245,0.018843824,0.014134197,-0.0647188,0.03987698,-0.009122297,-0.12794809,0.030480977,0.002312415,0.020731103,-0.027682552,-0.036891934,0.07227262,0.05709513,0.02231854,-0.004677085,-0.05749938,0.04610139,-0.060329814,-0.032541063,0.016766982,0.006625347,0.0038433922 +3.1.6.1,"Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities. The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate. This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC 1.8.3.7, formylglycine-generating enzyme, EC 1.1.98.7, serine-type anaerobic sulfatase-maturating enzyme, or EC 1.8.98.7, cysteine-type anaerobic sulfatase-maturating enzyme.",384,0.99999994,-0.051070586,-0.0859265,-0.065920286,-0.020740207,0.08264715,0.018458774,-0.035115123,0.028020103,0.050627492,-0.055003285,0.0005075638,0.019482788,-0.023143433,0.075125664,-0.03996606,0.024943687,-0.066146664,0.0011821233,0.00076801615,-0.045012705,0.11460724,0.025732005,-0.05729684,-0.026895458,0.01648324,0.03238053,0.04519858,-0.0015251605,-0.07016733,0.014889518,-0.059248883,-0.10847742,0.056335878,-0.045118965,0.034368496,0.03414754,-0.061960526,-0.021415211,0.0075098625,-0.04889104,0.093525134,0.06123733,-0.0028308015,-0.10201812,-0.027248623,-0.07079256,0.0028423588,0.0070924596,-0.0067505348,-0.041878648,-0.027499618,-0.05595768,-0.011430234,0.008887485,-0.041641116,-0.084368214,-0.10098501,0.00010433166,0.018161071,-0.021927819,-0.030762553,0.0046453965,0.0332892,-0.108714364,0.02985616,-0.040644202,0.05619152,-0.093637876,0.027062723,-0.0021818222,-0.10904099,-0.033680707,-0.081292205,0.052751016,-0.03435353,0.08375864,0.039457805,-0.042369198,0.018397447,-0.04397989,0.040759332,0.0073465146,0.031467754,0.10208628,0.050086234,-0.00995909,-0.0058343085,0.05493352,0.041694924,0.055723935,0.02343383,-0.012426089,0.0022587115,0.03109088,-0.022646416,-0.015853038,-0.018532895,0.20591834,-0.008680333,0.004505058,0.056944434,0.06252629,-0.04181803,-0.08848404,0.037745204,0.010864117,0.024656609,0.10373667,-0.0064775646,0.009148499,0.01467852,-0.031664655,0.04994186,-0.003729826,-0.045203384,0.14138192,0.032587945,-0.03199127,-0.16198301,0.06327505,0.049104117,0.014470625,0.06190918,-0.019789392,0.033108115,0.026713504,-0.18110906,3.8327434e-33,-0.0024982216,0.10629066,0.06877133,-0.0073147165,-0.03348927,-0.074047826,-0.06072986,0.056988116,0.018707843,0.027711516,-0.021820813,-0.021498485,0.0464614,-0.061879586,-0.03996922,0.0017581064,0.01213622,0.019727373,0.0018473123,0.0071163434,0.009840129,0.018891072,-0.015357411,-0.0546781,0.019350948,0.0060498584,0.02474827,-0.021147097,0.037159037,0.01757604,0.045580916,-0.1252126,-0.0936753,-0.021197205,0.08272053,-0.046313547,-0.018450739,-0.02041255,0.017506901,-0.026178684,-0.021528723,0.017665323,-0.031046854,0.0130079985,0.020400926,-0.058334135,-0.04894843,0.11715975,-0.015045141,0.017715659,0.028274424,-0.05002067,0.111913405,-0.018176856,-0.009807342,-0.001547151,0.023340592,0.03859887,0.0639108,0.02944628,0.044856507,0.04675645,-0.05227951,0.016391642,-0.042341605,0.034227353,-0.052318946,-0.057400383,-0.005175016,0.1129917,-0.022885365,-0.010022124,0.03157837,0.07982764,-0.0072528063,-0.044755906,-0.024816701,0.019314643,0.048656944,0.012369041,-0.053957682,-0.050811633,-0.009278328,0.00097204244,-0.120238155,-0.031171001,-0.027308457,0.040840164,-0.02410092,-0.038100086,0.025549913,0.0023989442,-0.037447043,0.017736768,-0.014868601,-4.271609e-33,0.08434067,-0.03294662,-0.031949203,-0.16803649,-0.06901815,0.023948397,0.029410722,-0.0195198,0.04464731,-0.062266447,0.041963685,-0.020027475,0.04893577,-0.022203011,0.042589795,0.019882487,-0.027368287,0.010295243,0.015304948,-0.047453925,0.00057008764,0.05351783,0.053312037,0.09198905,-0.026460921,0.019688623,0.0036130007,0.0523724,0.056190107,0.0995203,-0.0066085854,-0.0040559405,-0.00059249933,-0.10256907,-0.072375,0.026345212,0.016571313,-0.053928368,0.051666792,0.04762314,-0.026680173,-0.032951064,0.053932928,0.09946649,0.014851835,0.038408972,-0.041940402,0.04792445,0.010536817,-0.09600822,0.021211347,-0.016881853,-0.015434634,0.00895049,0.0063440823,0.07997034,0.014113499,-0.011929381,-0.06325014,-0.012588179,-0.056510925,-0.02658372,0.0051080734,-0.024002124,-0.011816814,0.008013587,0.0073750108,-0.05661411,0.01862459,-0.02659659,0.020075733,0.02766884,-0.029792761,0.0013242377,-0.0002084055,-0.04948301,-0.009293356,0.094168164,0.02536849,-0.040078457,0.004916232,0.031354897,0.030065533,-0.022989318,0.028135307,-0.0576169,-0.013495519,0.15623285,-0.03314783,-0.024592223,-0.03532607,-0.057940155,-0.032988507,0.09889494,-0.06489373,-4.537711e-08,-0.00056730665,-0.058086567,0.04241169,-0.011185809,-0.04174209,0.07891465,-0.06406888,-0.023084115,0.049097225,0.016214836,0.032668192,0.06399099,0.009690292,0.0140347425,0.056775164,0.001420338,-0.034566056,0.029282073,-0.015665656,-0.045919273,0.0041004466,-0.021201683,-0.07039533,0.020360567,0.07858358,-0.04301091,0.009910366,-0.009223179,-0.105817884,0.04170781,-0.0021570015,0.038295597,0.018316144,-0.0201282,-0.0036112424,0.027331278,-0.017718228,-0.051573064,0.0035232564,0.013610207,0.0068159215,0.023216823,-0.11262131,0.0046788314,0.061921265,0.02699264,0.021389302,0.040100686,-0.013464761,0.005817895,0.032913823,-0.004420049,-0.008440954,-0.02641202,-0.03121711,0.039744146,0.036033124,-0.12104397,0.08231569,0.0029474336,0.12560607,-0.03471955,0.11921792,-0.016194595 +3.1.6.2,Also acts on some related steryl sulfates.,384,0.99999994,-0.06995042,-0.056946725,-0.008139152,0.02489793,-0.039711986,-0.0062360973,0.006798158,0.004045978,-0.018715069,-0.04471934,0.05576757,0.08258601,-0.04766053,0.07786276,-0.03635997,0.07925974,-0.0016875588,0.06106042,0.004856602,-0.011550771,0.033151582,0.01421579,-0.035873935,-0.025766706,-0.02887199,0.07782837,0.04290074,0.02624847,-0.0010836455,-0.03392411,-0.01764127,0.0017498068,-0.015427011,-0.064909786,0.035967562,0.051280007,-0.041570313,-0.024501557,0.01671589,0.03863178,0.04988989,-0.03061145,-0.0014884886,-0.063854665,0.017605748,-0.095072225,0.022918979,0.023103872,0.021329604,0.03288415,0.010664722,-0.056987017,0.0055775633,0.0112484535,-0.06461195,0.02543731,-0.08053588,0.02544179,-0.0711747,-0.017425822,-0.018553082,-0.040991697,-0.06844108,-0.0049360017,0.0016777832,0.006554282,0.04642691,-0.03600961,0.03226389,0.006366197,-0.013619279,-0.01467851,-0.0035644707,0.09171216,0.02706397,-0.0105506815,0.0041896002,-0.110148445,0.0672552,-0.019259855,-0.008991599,0.07635526,0.0029184162,0.061502907,0.08274317,0.009254717,0.029581431,-0.04045941,-0.019376835,0.02728047,0.045460504,-0.00898044,-0.045328796,0.06352327,-0.046047945,0.0022233892,0.016000615,0.07371843,-0.04321123,-0.022206562,-0.04866348,-0.033297386,-0.06166756,-0.022275452,-0.0126807,0.010907604,0.013894378,0.030492509,-0.04242675,0.01375052,-0.030679468,0.017326329,0.050315917,-0.011767403,-0.1071648,0.09501607,0.08399364,0.007237689,-0.07891728,-0.044463046,-0.012323063,-0.026998272,0.01614244,0.028990587,-0.017066177,0.039977457,-0.06891748,-3.303187e-33,0.054515045,0.011686754,0.069921516,0.016981069,-0.023574755,0.027811697,-0.06745909,0.018501626,0.00415249,-0.060269803,-0.033604283,0.007932507,0.05524362,0.025663182,-0.011686609,0.0010421565,0.0023466165,0.05608581,0.072851785,-0.110532835,0.026126618,0.116477095,-0.08249813,-0.016772682,-0.09490724,-0.0046190917,-0.01100516,0.0014767143,-0.008471204,0.018342132,0.08323516,-0.0151578095,0.005681866,0.021117777,0.023448998,0.13644573,-0.039941307,-0.06011359,-0.005699924,-0.019781867,0.020239187,0.00047852864,-0.036195673,-0.041298263,0.008142273,-0.10674901,-0.1138208,0.038223293,0.021295473,0.051137984,0.032071277,-0.002114837,0.03141158,0.07248759,-0.048445232,0.03314833,-0.0033936289,-0.08855919,0.014023035,0.037458535,-0.06290592,0.042574603,-0.032674532,-0.006606375,-0.023065902,-0.029935502,-0.0642469,0.017774843,-0.08307402,0.03401818,-0.056700766,-0.0047057015,0.052964218,0.009593541,-0.044409536,-0.0062830816,0.0065092016,0.023571843,-0.0041207024,0.05950096,-0.05989503,-0.09863804,0.036481246,-0.01337427,-0.09870495,0.046445195,0.006916745,-0.035234693,0.015333159,0.03179431,0.07453516,-0.044637043,-0.12347615,-0.008447527,-0.043940287,1.9433486e-34,0.011019593,-0.11741279,-0.0027734037,-0.009390552,0.0028225086,-0.03395295,0.051383443,0.035058543,0.019798037,-0.03168777,0.027247729,-0.010459593,-0.03576747,-0.029170733,0.020206299,0.08223715,0.03501267,0.044896867,-0.030786663,-0.043811433,-0.04482715,0.14514048,0.084913105,0.10171688,0.04334534,-0.010628194,0.05243112,-0.02167861,0.0072935754,0.10551602,0.025398724,-0.04633748,-0.0626104,-0.040257484,-0.017707424,0.004404196,-0.023685,-0.06315317,-0.0024668383,-0.019908844,0.01806023,-0.09853255,0.06004143,0.12120963,0.07331284,0.09459345,0.007008724,0.009733754,-0.058532167,-0.021944935,0.03593741,-0.002261492,-0.029154608,0.058271438,0.041089166,0.012713655,-0.020758076,-0.078238755,-0.01151752,0.031963933,0.021539204,0.052396253,-0.07817267,-0.09567444,0.035296276,-0.005206346,-0.021753786,-0.033731785,0.08086562,-0.063962705,0.07810754,0.011996013,0.0041267164,0.01634309,-0.081180446,-0.06683829,-0.06900962,0.017189309,-0.052825075,-0.008791002,-0.08312872,0.008952694,0.05626324,-0.013684665,-0.017142206,-0.026479974,-0.086450085,0.080738746,0.012133807,0.02915743,-0.08366074,0.018598357,-0.0596838,0.04121202,0.010582743,-1.6109418e-08,0.014644173,-0.036899157,0.066588745,-0.050488442,-0.11949624,0.034404337,0.08995366,0.06514638,0.07107195,-0.003209738,-0.029412584,0.12554438,0.037825294,0.0054673525,0.0043905266,-0.03040473,-0.032927614,-0.0027106137,-0.08163041,-0.13814113,-0.11840013,-0.0037131782,0.035581306,0.082909375,-0.030309265,-0.036265794,0.050779074,0.039818324,-0.019242102,-0.07495351,0.07047106,-0.034455188,-0.0021750878,0.00020584484,0.025825227,0.1393282,0.09324339,-0.05057351,-0.017847698,0.072865285,-0.043342333,-0.06404474,-0.024783777,0.071575806,0.027830403,-0.013413687,0.037367854,0.050895985,-0.0028925918,-0.040840596,0.039556175,0.0071108253,-0.056029264,-0.01551045,-0.07675021,-0.0046374616,0.013739064,-0.058972996,0.104240485,0.017219977,0.04167865,-0.03578462,0.16081521,0.06105858 +3.1.6.3,Also acts on other sulfates of monosaccharides and disaccharides and on adenosine 5'-sulfate.,384,0.99999994,-0.0634027,-0.09146509,0.039464436,-0.006150805,-0.02281176,0.0125377495,-0.0072503886,-0.018726889,0.104223855,0.042782277,0.029117793,0.052663185,-0.034622997,0.037166607,-0.0619626,0.039670397,-0.0016817489,0.0623926,-0.009921458,-0.08090053,0.09378326,-0.029893663,-0.054977953,0.0178411,0.020778187,0.037862573,-0.010260875,0.057425804,-0.028759522,-0.06480989,-0.06711086,-0.032007717,-0.003360867,-0.011445563,-0.03176269,0.11919412,-0.049142335,0.01108197,0.041405503,-0.06837663,0.043096762,-0.060256556,0.0014800013,0.017454298,0.01276175,-0.08190438,-0.04459376,0.06347324,0.059886675,-0.010069083,-0.0012542591,-0.08854415,-0.065003864,0.005757813,0.0493499,0.012390124,-0.1247411,0.013388925,0.04199514,-0.025601957,-0.013269158,0.007997573,-0.03303205,0.028324718,0.00059772696,-0.0037558845,0.04451909,-0.023383692,-0.07927864,0.044415157,-0.051478256,-0.014044687,0.04077409,0.049640875,0.018822797,0.015400729,-0.051829606,-0.07186558,0.013827634,-0.015874783,0.024687853,0.13469855,0.05353781,0.07347889,0.014857411,-0.028314091,0.006101353,-0.048629567,-0.02138907,-0.041033152,0.03815881,-0.02613514,-0.012845128,0.040627014,-0.026854724,-0.04005684,-0.009556927,0.042659376,0.01694751,-0.011743932,-0.016975028,-0.010697471,-0.03548322,-0.07824342,-0.041788064,0.0407726,0.016851293,0.04445078,0.0012272398,0.0628552,-0.043982916,0.01994431,-0.05444259,-0.020899985,-0.07779362,0.1076035,0.040128082,-0.035042163,-0.06182816,-0.032593388,-0.0784453,-0.057230003,0.014441138,0.053650353,-0.063581534,0.040463958,-0.008881117,9.1054555e-34,0.07576439,-0.045290988,0.08803497,0.0072599845,0.048406735,-0.009846239,-0.018677166,0.02241494,0.016666837,0.022278639,-0.05325031,0.0021057543,0.039615322,0.015447062,-0.027221974,0.048042998,-0.036703378,-0.032083865,0.025838787,-0.024465976,-0.04076868,0.049953807,-0.03728474,-0.023407435,-0.012998564,-0.023954043,-0.07438857,-0.00877545,0.07748304,-0.012590544,0.051187187,-0.025139434,-0.048437078,0.008646101,-0.0015043991,0.06265963,-0.06954063,0.005297067,0.008550185,0.023627156,0.0128423255,0.023357974,-0.022821305,-0.06401171,0.008196637,-0.07055812,-0.049677826,0.038021386,0.014489259,0.11604797,0.07560088,-0.0008818528,0.03220958,0.0010260505,-0.048169006,0.016597746,5.466057e-05,-0.06281279,-0.055141203,0.08199011,-0.0029610386,-0.013187261,0.04009428,-0.12564868,-0.010593197,0.07075025,-0.09943531,0.0073556737,-0.006656941,0.040255368,-0.080037475,0.026240004,0.031399306,0.038339805,-0.037467822,0.0064699906,6.1580567e-06,0.039186724,0.018153237,0.04264636,-0.0063975006,-0.09573902,0.057519566,0.0016808137,-0.123387285,0.07297079,0.012258964,-0.08036679,-0.0012245944,0.032012578,0.045289736,-0.026588684,-0.10847232,0.008115167,-0.018242499,-4.560025e-33,0.056239933,-0.08663721,-0.0031476824,-0.029881978,-0.050770424,-0.010234652,0.019180302,-0.045678027,0.003010102,0.0056734364,0.08751985,0.04403025,-0.011488769,-0.0010439957,-0.027802344,0.06704022,-0.033428863,0.063361995,-0.0656479,0.04484308,-0.04838871,0.16109277,0.10301202,0.027753454,0.08584574,-0.011830398,0.021462902,-0.023665717,0.063766785,0.059043054,-0.0040443446,-0.056623317,-0.09192678,-0.044358294,-0.013979394,-0.040391352,-0.05116195,-0.026293261,-0.027645335,-0.005966402,0.022151075,-0.011481803,0.062490482,0.09492131,0.051544193,0.07609381,0.0056058327,0.059564926,-0.045280494,-0.043873202,0.024437409,-0.0182817,0.020400457,0.11998278,0.0418233,0.08291509,0.039850056,-0.02638224,0.007175218,-0.043158617,-0.087247096,-0.025921844,-0.032937817,-0.15424076,0.043357182,-0.014301266,-0.08263734,-0.045384564,0.069810726,-0.00224555,-0.0053305887,-0.05506673,-0.03043498,-0.0650682,-0.07925835,-0.040909182,-0.018733261,-0.03013901,-0.046156254,0.016454207,-0.06676652,0.07648444,-0.008708306,-0.073881865,0.031513415,0.0014000975,-0.006967396,0.092235416,-0.0024433758,0.09657794,-0.039369963,0.03862245,-0.011447286,0.01731195,-0.014653105,-2.3956426e-08,0.044517007,-0.0126645565,0.017656088,-0.014372623,-0.045640334,0.049200784,0.043352112,0.062205303,-0.0034040834,0.06221942,-0.002180056,0.13434738,0.019745102,0.040420573,-0.0041254694,0.0072537386,-0.020892397,0.011616146,-0.027364662,-0.09747892,-0.16243699,-0.0550666,-0.06746475,0.09049698,0.018628567,-0.06915703,0.0840655,-0.019903678,-0.05800184,-0.019188058,0.054360628,0.047003523,-0.041216884,-0.11096492,0.055868164,0.10834574,-0.02180989,0.006462807,-0.024612905,-0.0030351158,-0.0065617766,-0.033178452,-0.036875352,0.045006815,0.023617819,0.040427607,0.023805443,0.07363211,-0.041007858,0.07183981,0.031588506,-0.027492888,-0.045708843,-0.024503114,-0.067296825,-0.007854489,0.026312452,-0.057526875,0.10327395,-0.018554466,0.010243932,-0.049968306,0.11171839,-0.025138494 +3.1.6.8,Hydrolyses galactose-3-sulfate residues in a number of lipids. Also hydrolyses ascorbate 2-sulfate and many phenol sulfates.,384,1.0,-0.013966517,-0.11135133,-0.04228877,0.003997057,-0.014223168,0.037469033,0.024532216,0.013134885,0.052343108,-0.03185934,0.015222519,0.021936804,-0.104373984,-0.02790935,-0.08127772,-0.006948924,0.029250555,0.055525146,-0.019592779,0.021405775,0.21539228,-0.0018415524,0.017192794,0.057285402,0.057259433,0.032824088,0.006163681,-0.06559443,-0.034791075,-0.072959885,0.013448298,-0.06888842,0.064896174,-0.037422653,-0.002293181,0.04551763,0.014544547,-0.04221956,0.021247637,-0.025518186,0.027103566,-0.03495278,-0.0058105458,-0.007071838,-0.00652368,-0.05686183,-0.0518747,0.080074996,0.08344738,-0.0090676285,0.0021480042,-0.07847288,-0.07722941,0.005617288,-0.05318161,0.058388833,0.0057375752,-0.029544441,-0.027939305,0.041491836,0.018046591,0.04672147,0.043836728,-0.007854582,-0.0545893,-0.052851148,0.03608996,-0.03287081,0.017767109,0.021285728,-0.05760637,-0.03872764,-0.014366875,0.001143741,0.01277001,0.067857064,0.0022415724,-0.053138338,0.03010479,-0.07680045,0.047250148,-0.056091826,0.0052021705,0.121561214,0.019138142,-0.054743785,0.005327265,0.012705933,0.01866551,0.0341692,0.0042872084,-0.039279874,0.03814474,0.050538313,-0.031054335,0.030564452,0.10411648,0.0058376603,0.07384991,-0.047536254,-0.01620516,-0.019455826,0.06894924,-0.035105832,-0.0036325753,0.076394215,-0.03776691,-0.005803577,0.026040876,-0.035306573,-0.026885802,-0.01978792,-0.001971078,-0.04265241,-0.030941404,0.07082122,0.020341977,-0.05532514,-0.054736096,-0.026386177,-0.021881314,-0.023011748,0.034352865,0.019831445,-0.039094765,0.08935615,-0.0148875145,1.44290205e-33,0.0800827,0.05550682,0.059208382,0.01606119,-0.07581781,0.010112249,-0.06795198,0.011336262,0.015992332,0.032730836,-0.0067804675,-0.014205603,0.031260837,0.04952918,0.008539599,0.021958895,0.0428425,-0.039093837,0.11970839,-0.056493044,-0.064381406,0.05388849,-0.08522466,-0.058709655,0.019292695,-0.034826152,-0.051785007,0.008462282,0.097870946,0.010043094,0.13143212,-0.09086325,-0.039414573,0.021093886,0.04009076,0.03784365,-0.017754983,-0.058416538,0.002022618,-0.017019343,0.028287742,-0.036880054,0.022785163,-0.056130707,-0.04740775,-0.027357971,-0.043039847,0.033691097,0.09147366,0.046147265,-0.013722574,0.01122595,0.038736362,0.08380581,-0.0140239,0.008839581,-0.02849028,0.010748279,0.025487326,0.035962105,0.008964572,0.06393002,-0.042440526,-0.039207395,0.014923893,0.05778786,-0.046681833,0.062753834,-0.041981447,0.016948223,-0.082552634,-0.029108426,0.07460487,0.013621412,0.0059749265,0.034069844,0.04725909,0.04793779,-0.04236582,0.049132425,-0.048981983,0.026486704,-0.012087071,0.027324794,-0.06977907,0.11933634,0.0019654224,-0.046774708,-0.008210523,0.02831006,-0.048293136,-0.03619191,-0.055075448,0.021373572,-0.10591763,-3.6610386e-33,0.03233406,-0.08529486,0.026769975,-0.017346052,0.0005134719,0.0024610262,0.06367744,-0.018192722,0.02967132,-0.0857224,0.005209999,-0.000840177,-0.015907673,-0.111775346,0.007583883,0.070386425,-0.034735303,0.00037632376,-0.031859796,0.005640372,0.03714295,0.07786649,0.046586007,0.111738324,0.009182557,-0.040396456,0.035174545,-0.06299911,-0.002898425,0.084606126,0.08992015,-0.032812648,0.005474936,-0.080062464,-0.05893194,-0.036017485,-0.09899235,-0.042832628,-0.022175394,0.03525742,-0.01352303,0.0040672845,0.07325839,0.05414664,0.11397505,0.10279192,-0.09021042,0.09205016,0.048008036,-0.012952603,-0.027593674,-0.055086795,-0.024581106,0.10548,0.048613302,0.05008421,-0.011398054,-0.006546077,0.044430204,-0.065316275,-0.036964484,-0.024275945,-0.014539749,-0.12743166,0.0005585252,-0.0012286053,-0.054683264,-0.051162265,0.008620459,-0.026670022,0.0035471749,-0.039091714,-0.026428323,0.03369233,0.012401001,-0.032344893,-0.11240704,-0.06280095,-0.081819534,-0.017069178,0.07905239,0.08501332,0.010719146,-0.092155375,0.019789578,-0.038834386,-0.029136963,0.11623541,0.011562659,-0.009255172,-0.05982678,0.008669974,-0.057799052,0.024409225,0.05517139,-2.6758595e-08,0.08494266,0.03848369,0.09979049,-0.08147383,-0.05479373,0.037973937,0.054200772,0.07513811,0.014381307,-0.001000516,-0.030186657,0.09897789,-0.031566102,-0.017001782,-0.03471957,0.019731952,-0.056345433,0.01413859,-0.023031164,-0.057419185,-0.059739772,-0.007031551,-0.08880678,0.009065694,0.02235039,-0.02583114,0.059505504,-0.032860838,-0.024877952,-0.008286302,0.09783639,0.041367017,0.013758957,-0.02604212,0.017221998,0.05717901,-0.032215223,-0.032146625,-0.010930286,0.047519132,-0.009065039,-0.06675639,0.014953164,0.016834654,-0.03732972,-0.00076475885,-0.015102774,0.08706379,-0.028974647,0.08502079,-0.038094986,-0.042555586,-0.09876101,-0.023274647,-0.056951102,-0.081826285,0.045488425,-0.051145922,0.016783036,-0.06319044,0.031220373,-0.04747633,0.13195336,0.0040486883 +3.1.6.9,"Also acts on the saturated analogue but not on higher oligosaccharides, nor any 6-sulfates.",384,1.0,-0.04775183,-0.1479208,-0.039169252,0.007572355,-0.035047702,-0.012797304,-0.044048585,0.00939179,0.04619698,-0.0069690016,0.03327245,0.06785059,-0.069163226,0.0034380762,0.009907671,0.014723181,0.051933326,0.034741975,-0.04558417,0.0037780846,0.12235906,-0.04066025,-0.023232415,-0.014034705,0.036453303,-0.033156846,-0.00056535355,-0.0035062367,0.0292271,-0.04137155,-0.072805576,0.02383118,-0.0070669386,-0.034830377,0.023987839,0.063092776,-0.043650217,-0.025919998,-0.012388488,-0.077182725,0.05254365,-0.042571507,0.05182829,-0.03511417,-0.010883195,-0.10848573,-0.019980412,0.046939906,0.039209273,-0.03801704,-0.057708085,-0.09544974,-0.07808793,0.06262202,0.013107844,0.026488436,-0.14632599,-0.017235268,0.046471447,0.00080195547,-0.020652259,0.05255824,-0.005215584,0.005494437,0.037239134,-0.02839029,0.06005243,-0.021101376,-0.06882326,0.07137367,-0.043758597,0.028890794,0.03714596,0.03619184,0.05596519,0.025029063,-0.057558388,-0.08659722,0.0324994,-0.010991487,-0.014726405,0.03257613,0.017365206,0.082009904,-0.00084442075,-0.05944402,-0.00044369773,-0.030280586,-0.013026887,0.0003858758,0.07332691,0.035361655,-0.001086592,-0.008581637,-0.10317856,-0.073461026,0.018813947,0.118926376,0.04143504,-0.011627701,-0.021862501,-0.004928028,-0.061117947,-0.08203578,-0.011523265,0.05491886,0.030602664,0.08190675,-0.0153172705,0.074016996,-0.014335599,-0.045945846,0.05669263,-0.07605632,-0.1356529,0.08507624,0.032746103,-0.040515836,-0.117161185,-0.029199436,-0.02958704,-0.010101387,0.062178668,0.084265985,-0.06904414,0.056004878,0.021053603,-5.848224e-34,0.052943848,-0.028098857,0.1070314,-0.00034767232,-0.0031039983,-0.020475,-0.022716345,-0.010332542,-0.014249535,-0.010055071,-0.048040047,0.008638718,0.018388005,0.0922089,0.028115802,0.048314232,0.0013658958,-0.054650526,0.031299073,-0.0026431829,0.039252277,0.110128984,-0.051395427,-0.013134489,-0.05002988,-0.018848037,-0.012146059,0.04533306,-0.00925963,0.015705911,0.100197725,-0.026064942,-0.045133,-0.005430291,0.049549256,0.08794908,-0.06897473,-0.0096632475,0.010770219,-0.042359162,0.039747432,0.0044492497,-0.023070753,0.0025565862,0.06363308,-0.07693875,-0.021355433,0.0113166645,0.0022707281,0.0962574,0.035129737,-0.007802368,-0.015345663,0.06231526,-0.04207214,0.016313167,0.046581354,0.01184584,-0.007065626,0.06897719,-0.043661527,-0.045754373,-0.0021845356,-0.08684757,-0.05799053,0.064257026,-0.055694908,-0.02038667,-0.02316592,0.023312263,-0.0490307,0.017055482,0.027227957,0.07446036,-0.00048257376,-0.049902197,-0.053791057,0.0061979447,0.02738553,-0.0061772442,0.02336396,-0.06861024,0.01963288,0.061938852,-0.14855951,0.061920524,-0.04023215,-0.0035559165,0.018982315,0.06347185,0.05367579,-0.04168313,-0.1124271,-0.015558867,-0.031415146,-2.3334476e-33,0.05695404,-0.052389555,-0.03893253,0.049486477,-0.040051218,-0.012594681,0.08898824,-0.03554739,0.033495102,-0.07931073,0.117217034,0.03769028,-0.014966447,-0.0033402133,-0.009570487,0.052517667,-0.04975152,0.09600257,-0.01522549,0.017451726,-0.097039506,0.07061903,0.031841997,0.05960916,0.062211562,0.02041367,0.003203902,0.017282207,0.042227168,0.08273796,0.03652983,-0.020004738,-0.100495666,-0.09844916,-0.047703218,0.009615787,-0.024508622,-0.059320025,-0.06775166,0.013206551,-0.0068894927,-0.037351657,0.037839036,0.042174336,0.067049354,0.06287216,0.036652174,0.033915132,-0.014042187,-0.018431151,0.07882517,-0.048602205,0.008280939,0.111764684,0.062210385,0.040392507,0.012981153,-0.06741284,-0.05133189,-0.03336737,0.0022053095,0.009550072,-0.00087443786,-0.16159807,0.0060862545,0.03855166,-0.042984057,0.017951468,0.0464666,-0.054348405,0.0006381703,-0.04266971,-0.013953281,-0.11289429,-0.01608129,-0.034943286,-0.011764453,0.0076692905,-0.045066353,-0.0031339892,-0.08547972,0.067333475,0.02326459,-0.049631137,0.02905583,0.010071775,-0.013852331,0.0049591227,-0.00039461596,0.11816389,-0.050109465,0.0063397684,0.017644001,-0.012358,0.039948422,-2.3253063e-08,0.06156119,-0.0064051077,0.01394378,-0.014165509,-0.05322822,-0.019797714,0.033107664,0.0035634143,-5.5724013e-05,0.070434354,-0.027413107,0.102922894,0.013543149,-0.023995792,0.0050585396,-0.031195201,-0.004251905,0.016575476,-0.08560708,-0.04858762,-0.098472826,-0.009857992,-0.06629487,0.03618251,0.038726944,-0.056796975,0.058545884,-0.058919813,-0.03208347,-0.02352241,0.06141662,0.027006598,-0.027631236,-0.055273507,0.043323506,0.11047759,-0.038768094,-0.020954562,-0.034579836,0.008599765,-0.001472512,-0.045435145,-0.04507597,0.021521607,0.044871405,0.056311745,0.0039297114,0.082981266,-0.041244205,0.073155105,0.0017493555,0.0017779518,-0.04714295,-0.052332755,-0.056093566,-0.043317568,0.017197248,0.0022967989,0.06725022,-0.037835564,0.09275708,-0.06435451,0.111171305,-0.027348123 +3.1.6.10,"Also acts on the saturated analogue and N-acetyl-D-galactosamine 4,6-disulfate, but not higher oligosaccharides, nor any 4-sulfate",384,0.99999994,-0.00058956357,-0.12702653,0.00011068354,-0.008162361,-0.0034957516,-0.008086993,-0.030667305,0.016689524,0.060934454,0.008344463,0.012411266,0.057423003,-0.041799754,0.034560475,-0.030765556,0.030342434,0.094013095,0.04458378,-0.018868009,0.015911108,0.118513994,-0.10342992,0.0071368534,0.0072671436,0.02886746,-0.020577809,0.04029143,-0.048750147,-0.005175065,-0.09029164,-0.034274213,-0.05033737,0.058339193,0.0026027313,-0.010275498,0.058426045,0.031368766,-0.018037194,-0.002065909,-0.05526838,0.027842253,-0.03255216,0.056897722,-0.0026785757,-0.01824113,-0.08313434,-0.043459672,0.06583666,0.05231107,-0.041562717,-0.033318423,-0.06377562,-0.055328924,0.0724479,0.04130841,0.03223487,-0.12714732,-0.025943061,0.058711253,0.029879732,0.068316296,0.06381807,0.018721929,-0.04031958,-0.008034051,-0.027096568,0.04650166,0.0093024075,-0.05002333,0.09044605,-0.0274297,0.064317904,0.0058387527,-0.012754454,0.0736922,0.023563746,-0.05961314,-0.07334355,0.066027544,-0.03653301,0.025928793,0.063904904,0.01664871,0.06333578,0.026431985,-0.039527398,0.013202348,-0.008478669,0.0077907727,-0.025019659,0.02401144,-0.004163673,-0.028375898,0.005807357,-0.11934259,-0.09102527,0.015717983,0.0744039,0.043906808,0.012235262,0.012036362,-0.00987205,-0.048425905,-0.08620252,-0.049082905,0.050771516,0.039260346,0.07799825,-0.0067878817,0.05805923,-0.035213325,-0.050199207,0.014820696,-0.014357393,-0.16995509,0.07645353,0.0034079778,-0.0877163,-0.12797493,-0.042776786,-0.021292152,0.0070457896,0.073110536,0.058675498,-0.029742861,0.058311787,0.021076472,1.8328203e-33,0.062429536,0.009643623,0.12359572,0.038893297,-0.0023750518,-0.008442726,-0.011995427,-0.04798251,0.0036665015,-0.029349504,-0.054752696,0.0002541005,0.04305185,0.09570911,-0.0037437405,0.056003314,-0.004206369,-0.023311857,0.036592986,-0.017889569,-0.009013441,0.12552541,-0.09022586,-0.009212559,0.008787555,-0.032073848,-0.022019023,0.040324192,0.080687344,0.036002595,0.072167695,-0.033772264,-0.04607322,0.011325745,0.040976748,0.063474454,-0.09115764,-0.04240698,0.025038596,-0.08305959,0.01405395,0.0059189973,-0.02020646,-0.013227484,0.006717173,-0.03794783,-0.020655205,-0.005066198,-0.01770357,0.07311598,0.032381084,-0.023739804,-0.024491308,0.017579047,-0.055685785,0.04503915,-0.018621176,-0.02699082,0.018396256,0.042638056,-0.012281917,-0.0034549744,-0.04340834,-0.08626187,-0.023761677,0.056725178,-0.010441538,-0.04885405,-0.026699279,0.028508797,-0.028115653,-0.029435007,0.033171877,0.06769817,-0.025126921,-0.049698178,-0.008439565,-0.008768604,0.018692326,-0.014330903,0.0058969893,-0.04700498,0.027041947,0.026099361,-0.106295824,0.052806973,-0.01858369,-0.01727038,0.043171294,0.08493226,-0.015269923,-0.0573453,-0.10735266,0.021051072,-0.021056473,-2.9728085e-33,0.08880175,-0.038762704,0.015361999,0.038736273,-0.059929628,0.025375742,0.07575388,-0.016968135,0.052843332,-0.07153485,0.12583156,-0.023999128,-0.013605879,-0.00048323232,0.021576563,0.05267281,-0.052019097,0.036531948,-0.012581561,0.03251519,-0.08282331,0.0838902,0.04101552,0.052181248,0.059023935,-0.0015576686,0.046960164,0.0213761,0.056402862,0.06271088,0.027506331,-0.0074126353,-0.07902953,-0.059670612,-0.069509774,-0.021959743,-0.031092914,-0.04199161,-0.07514214,0.0036698985,-0.036726326,-0.009206573,0.046607893,0.054661747,0.055598933,0.034972694,-0.002773356,0.06701525,0.04141374,-0.029087719,0.048553597,-0.07445959,0.008205157,0.095435955,0.06692273,0.055699773,-0.008029374,-0.017998628,-0.026337529,-0.053947035,-0.032513462,-0.0067774113,0.028929519,-0.16762303,0.03163186,0.00013438411,-0.10326745,0.017069643,0.025899092,-0.044972688,-0.021127624,-0.057805922,-0.0012502661,-0.038566582,0.0078092823,-0.043222632,-0.098287195,-0.024401492,-0.072774336,0.011702804,-0.038138896,0.064029574,0.035696507,-0.070361815,-0.0020495665,0.023544697,0.043981716,0.07234265,0.0007973662,0.103385136,-0.03227167,0.019732188,0.016620602,0.01817826,0.005838239,-3.0438425e-08,0.068507284,0.04063112,0.012586179,-0.068743594,-0.10765876,-0.032545436,0.028525544,0.03208518,0.0010265579,0.04652411,-0.0028796736,0.14062788,-0.009917332,-0.018953983,-0.009874334,0.0022481983,-0.024152676,-0.015451289,-0.056658786,-0.050554547,-0.079017095,-0.0036460937,-0.059948314,0.020516539,0.015018852,-0.015422512,0.09848768,-0.050195374,-0.043656506,-0.019487333,0.063418485,0.04239855,-0.01420567,-0.11361527,0.038332805,0.09969688,-0.07375608,0.0034867078,0.024478277,0.03436472,0.037955306,0.005077546,-0.0033534495,0.02233163,0.019414557,0.022119211,-0.018233318,0.067502744,-0.034912392,0.09281085,-0.069627464,-0.024673374,-0.09207026,-0.073035814,-0.05243025,-0.05057087,-0.013684497,0.006086122,0.052636437,-0.05325016,0.07745413,-0.09057934,0.082469046,0.033861876 +3.1.6.11,May be identical with EC 3.1.6.14 N-acetylglucosamine-6-sulfatase.,384,1.0,-0.08993572,-0.075643085,-0.085737385,-0.019552372,0.0054033045,-0.0073326435,-0.046081405,0.041960284,0.048320226,-0.09138972,0.04752784,-0.0064129913,-0.04938334,0.014142955,-0.09028566,-0.020945944,-0.016340306,-0.06476711,0.008596255,-0.034205887,-0.0074270484,0.046416037,0.010423656,0.021527795,0.046506364,0.048205994,0.022940066,0.0059551536,-0.031619716,-0.084815815,0.031742528,-0.05343365,0.056688312,-0.025790347,0.110572435,0.034516476,-0.043169472,-0.035936255,-0.024105106,0.034794427,0.05993822,-0.0013374065,0.027619319,-0.039188016,-0.002836703,-0.01545032,-0.12370118,0.06614002,0.065178506,-0.015486299,0.034469467,-0.1049092,-0.057279814,0.05923983,0.034653425,-0.006358188,-0.12658836,-0.0017069489,0.010662332,0.066566855,-0.016927466,0.08956237,0.042930793,-0.039771296,0.06391681,-0.026673477,0.10561234,-0.14444792,-0.006302775,0.033954635,-0.07984462,-0.028089035,-0.00488226,0.063855775,-0.038956445,0.048237607,-0.043496277,-0.058526628,0.04228129,-0.039174058,-0.029375607,-0.014345896,-0.0544068,0.0684882,-0.015547637,-0.054763157,0.03848172,-0.009551028,0.02275128,-0.0005376219,0.021516476,-0.0637209,0.014315721,0.001958913,-0.103917465,0.031740326,-0.019534532,0.16855755,0.02454865,0.013207346,0.017340258,0.04422867,-0.022068001,-0.0787685,-0.008243766,0.020612031,0.017743863,0.096097425,0.013891274,0.0020186221,-0.041015726,-0.034121297,0.031325422,0.017543774,-0.051764276,0.11119883,-0.005901062,-0.058292173,-0.012528213,0.06940565,0.061989006,-0.04445625,0.07124306,0.016704632,-0.015926013,0.039830383,-0.07325211,4.0066926e-35,0.046366397,0.014328939,0.12323406,-0.041287053,-0.035401665,0.021005385,-0.09888948,0.020700958,-0.03643931,-0.031031122,-0.057769828,0.006173753,0.06422668,0.009918974,-0.062427677,-0.0039848727,-0.03054105,0.03890121,-0.024762223,-0.033975456,0.020088583,0.03887919,-0.040428933,-0.013826968,0.02489026,-0.006529165,-0.038173392,0.037273288,0.08006137,0.011955044,0.034815256,-0.06571091,-0.023127753,0.034890804,-0.051399436,0.0021725658,-0.011757118,-0.097795255,0.026224995,0.0076106437,0.073207,0.06587867,0.038791824,-0.041707907,0.009777976,0.0047556385,-0.086755335,0.03231958,0.055272993,0.04106459,-0.0170719,-0.04699337,0.11481856,-0.04944446,0.035828296,-0.010183619,-0.026761796,0.037900683,0.07146178,0.028393634,0.027987054,0.14029743,-0.04351221,-0.027548688,-0.05798927,0.021674674,-0.053941812,0.0111430315,-0.03426657,0.017154101,-0.06611147,-0.010696143,0.0035858697,0.069290146,0.061168082,-0.1061826,-0.0529624,0.020082677,-0.07513798,0.016792204,-0.097419605,-0.021628637,0.007431776,0.0048885015,-0.1527966,0.017485956,-0.009728642,-0.00021743322,-0.024678085,0.06277758,0.042938292,-0.010054548,-0.082930006,0.086882204,-0.010530371,-1.47708175e-33,0.037099533,-0.04047429,0.067695096,-0.049892798,-0.015873246,0.051653523,0.075265326,0.06670797,0.050836615,-0.03167488,0.10814419,0.010482024,0.010416951,-0.06958574,0.071718186,0.022427645,-0.024946678,-0.0070861108,0.042088795,0.07728797,-0.034997452,0.061404865,-0.07988389,0.056286424,0.0076291426,0.024957225,0.033989623,-0.00046834754,0.044119272,0.025222516,-0.056984223,-0.0014865348,-0.050740853,-0.025372311,-0.06950862,-0.035948098,0.05122386,-0.07799328,-0.05929478,-0.0729651,-0.035317454,0.043002352,0.02381375,0.10356696,0.06881579,0.11219387,0.04268196,0.0017841007,0.005480564,0.004576731,-0.005002082,-0.04668384,-0.020088907,0.0683414,0.0019827136,-0.0006054826,-0.0076297023,0.010943819,-0.057214998,0.005714187,-0.014331361,-0.02424986,-0.007093062,-0.07726928,0.0015064336,0.06802504,-0.0376243,0.012583309,0.049165845,-0.030424207,0.023209741,-0.05465265,-0.048285544,-0.048067383,-0.026699333,-0.06212806,-0.022857834,0.028509945,-0.018712748,-0.08436989,0.031475503,0.031618576,-0.0053182472,-0.017041748,-5.254934e-05,0.037382346,0.043603696,0.08298584,-0.052565657,0.053657092,-0.06496271,0.00015712943,-0.14781585,0.04077886,-0.022228576,-2.5957394e-08,0.08278438,-0.048776507,0.04411962,-0.015805772,0.043872736,0.010306924,0.027265007,0.05607212,0.02384797,0.0498013,-0.010440201,0.07860398,0.0625396,-0.0223422,-0.007387671,-0.038955618,-0.06535192,0.029587287,-0.0023744823,0.02660007,-0.03822405,0.008879914,0.0074005155,-0.022806784,0.005598054,-0.0077342936,0.049301114,0.042465508,-0.051393166,-0.0564803,0.010596118,0.026902344,0.0035427958,-0.032443598,0.030842392,0.03377799,-0.06034011,-0.024449963,0.0067407032,0.040433478,0.023033593,-0.014365961,-0.04565162,0.0012288737,0.054130524,-0.017508294,0.04805674,-0.031681273,-0.031988744,-0.03238593,-0.0054013687,-0.03166616,-0.015914764,-0.07931006,-0.022264464,-0.018887835,-0.03400884,-0.11802189,0.04586327,0.013394342,0.09253301,-0.11416686,0.11898972,0.080936596 +3.1.6.12,Acts also on N-acetylglucosamine 4-sulfate.,384,1.0,-0.04044817,-0.07156061,-0.052762263,-0.032450914,-0.00012567696,0.0568136,0.033453465,0.014773328,0.0060924576,0.011025262,-0.00527729,0.06753215,-0.048406553,0.06616177,-0.096059054,0.10945459,0.046094,0.00814988,0.0370337,-0.056797605,0.022466285,-0.04179518,0.004083828,-0.048634566,0.0024815837,0.06189286,-0.0066583715,-0.02014989,-0.010381173,-0.10980052,-0.0031782123,-0.013555963,0.0140507575,-0.009559997,0.06646396,0.04383247,-0.062177032,0.019929752,0.008132463,0.0101206945,0.058191415,-0.029717559,0.016182506,0.00032196642,0.034978256,-0.040177066,-0.028371671,0.01143793,0.08083278,0.044525336,0.02850499,-0.027986877,-0.02554164,0.08277677,0.0057286355,0.007576946,-0.16255125,-0.0048838193,0.039931156,0.0789632,0.037519895,0.020926615,-0.02211293,-0.033007804,0.04386739,0.020448254,0.08907652,-0.08959235,-0.022617934,0.024178935,-0.0072503267,0.0057851397,0.0033063611,0.010837845,-0.01203993,-0.0116761485,-0.04027313,-0.06364282,0.037327796,-0.018693134,-0.017432224,0.075382404,0.039777335,0.07655878,0.051657725,-0.011984829,-0.02289348,-0.053188756,0.06247235,0.04273388,-0.008668277,-0.053284556,0.009902702,-0.0039525013,-0.06129502,-0.015594442,-0.0006959632,0.07784714,0.021586435,0.037600506,-0.020257924,0.007874991,-0.06936191,-0.12757695,-0.063246645,0.03530464,0.058458015,0.06417503,0.003976544,0.04579415,-0.09129607,-0.00035358028,-0.012600361,0.021127686,-0.099079765,0.081747256,0.008044685,-0.06806894,-0.07256969,-0.05138474,-0.012361401,-0.025243316,0.039731875,0.024794703,-0.036406018,0.07691833,-0.02022091,-2.0846853e-34,0.10679146,0.039031602,0.09025701,0.0086272415,-0.0030055768,0.030829413,-0.05956237,-0.033214197,0.013824059,-0.044155076,-0.02385318,-0.005562731,0.06894284,0.069775805,-0.047309753,0.05909654,0.004204361,-0.021214897,0.052327428,-0.0618566,-0.035415072,0.114500746,-0.12419888,0.05709584,-0.07881046,0.008974303,-0.028790953,0.031420812,0.03892163,0.007287879,0.050915293,-0.03133328,-0.047553293,0.0066396715,0.007991642,0.0457224,-0.044757523,-0.025434954,0.040381055,-0.017025936,0.041966036,0.07081269,-0.025930738,-0.030875865,-0.0018861603,-0.059566174,-0.091751784,0.040961865,0.018638343,0.08629051,0.03988696,-0.054025937,0.07653948,-0.0031594415,-0.04645899,0.064964265,-0.05595326,-0.061288476,0.030838182,0.01770277,0.008189824,0.00474841,-0.03186673,-0.09154938,-0.014834413,-0.022727022,-0.041206155,-0.027114693,-0.007965957,-0.024893858,-0.05226683,-0.019236775,0.06930645,0.061176296,0.01687887,-0.06315891,0.011724949,0.044774007,0.023587357,0.031943668,-0.019875854,-0.06370112,0.05424623,-0.019533448,-0.08666468,0.01609187,0.036208715,-0.1179448,-0.0013659721,0.041027304,0.0050308625,-0.09672957,-0.11202753,0.027050529,-0.009238046,-2.0794633e-33,0.06455331,-0.047499973,0.032399226,0.018403731,-0.07098983,0.048553284,0.051890224,-0.051895183,0.019967884,0.019147191,0.08383524,-0.0011454788,0.0133246,0.0049231136,0.059546202,0.019428898,-0.031920288,0.018279824,-0.02015808,0.0143668875,-0.04415026,0.12757404,0.013735203,0.07610097,0.036667455,-0.0034437221,0.026127055,0.003790849,0.045623418,0.118608825,-0.053795993,-0.013834753,-0.07730031,-0.037443765,-0.029077321,-0.027739389,0.03741652,-0.019433605,-0.10725732,-0.07521449,0.033251002,-0.024603814,0.008546011,0.12659846,0.03150928,0.0844678,-0.004898403,0.02442234,-0.05230394,-0.01440549,0.020648323,0.013120209,-0.030555528,0.030093731,0.06970176,0.08144832,-0.005168285,-0.056921422,-0.03735707,-0.011023517,-0.021514768,-0.0027417755,-0.027963154,-0.11956421,0.05287648,0.03599421,-0.044387486,-9.126814e-05,0.04811758,-0.045222472,-0.016536564,-0.020141391,0.05111751,-0.010375409,-0.054455813,-0.09692281,-0.024760436,-0.07138405,-0.079551324,-0.059806064,-0.032670084,0.021233404,-0.007078421,-0.081003904,-0.028435014,0.016385999,0.023287358,0.12168616,-0.034660604,0.07239815,-0.04763913,0.020384438,-0.07194807,0.048061114,-0.05385655,-2.3551928e-08,0.052403066,0.07427056,0.09589065,-0.04453243,-0.08280711,0.03588855,0.038321704,0.058219202,0.035875183,0.00012680839,0.0007589245,0.15012738,0.043564335,0.009796566,0.009737229,-0.02016317,-0.027536439,-0.016945347,-0.0781423,-0.016048133,-0.15039682,-0.004760662,-0.011321495,0.042277362,-0.035048213,-0.06226682,0.119446665,0.025707101,-0.017724978,-0.047092374,-0.010583795,0.025050271,-0.0007109742,-0.10739378,0.031653725,0.042866766,0.024173513,-0.028173907,0.043362096,0.042155113,-0.0075304033,0.009829115,-0.01911792,0.06937519,0.008692557,-0.010862355,-0.009331651,-0.034642592,-0.036347564,0.05261743,-0.015006165,-0.013812661,-0.08428102,-0.064303756,-0.08361785,0.025548924,-0.002397749,-0.05630748,0.09802988,-0.04016686,0.015305683,-0.08188825,0.053988308,0.031703535 +3.1.6.14,May be identical with EC 3.1.6.11 disulfoglucosamine-6-sulfatase.,384,1.0,-0.097033575,-0.075069636,-0.03334717,-0.042496044,0.029830752,-0.053160388,-0.04483641,0.058584403,0.056819733,-0.077450566,0.04610496,-0.015527543,-0.059011903,0.0071968683,-0.060191713,-0.01953458,-0.0040143915,-0.028522508,-0.011008072,-0.0054950877,-0.0020891165,0.02707149,0.024749285,0.045223277,0.038665105,0.06723856,0.02837185,0.03956414,-0.024892254,-0.07662593,0.013324967,-0.0515083,0.04040277,-0.01955944,0.049183678,0.07137429,-0.038231205,-0.06920929,-0.032328714,0.03603934,0.0582434,0.024679774,0.024527384,-0.03872317,0.0028950444,-0.017965145,-0.12743647,0.09606185,0.065187775,-0.029873516,0.018485453,-0.0930098,-0.051306073,0.059883833,0.020402005,-0.022632098,-0.10496382,0.029396769,-0.0064797862,0.043515723,-0.047163744,0.08563007,0.057844758,-0.017506188,0.034006547,-0.030327395,0.09067788,-0.10822826,0.013746599,0.015254327,-0.1033701,-0.017980581,0.030014182,0.046476696,-0.013001551,0.0900439,-0.03558671,-0.0491441,0.023463318,-0.063563034,-0.019084398,-0.007344657,-0.039375007,0.0715351,-0.003586938,-0.04459858,0.03445013,-0.039872948,0.016819224,-0.0038116241,0.04448071,-0.03053238,-0.016114503,0.006758263,-0.0957151,0.032424204,-0.04077476,0.19482116,0.02131502,0.00590174,0.0042399256,0.030259944,-0.06701627,-0.0672561,-0.014805191,-0.007219329,-0.0016875096,0.085714646,-0.022631433,-0.026008993,-0.033423323,-0.027478492,0.027595114,0.03080199,-0.062342558,0.07833229,0.015225183,-0.06706822,-0.013498071,0.04984026,0.053155698,-0.049552362,0.06053045,0.017417483,-0.062445458,0.0111607835,-0.07710399,7.91087e-34,0.031523105,0.014748013,0.11098384,0.0018347366,-0.061610952,0.04686956,-0.12388285,0.026494766,-0.0932711,-0.033876307,-0.060107492,0.010710695,0.05639607,0.0020862576,-0.030915149,-0.030236213,-0.011043863,0.06449211,-0.019020166,-0.051376686,0.04688313,0.03506259,-0.047393434,-0.046515595,0.06261571,0.016649634,-0.0326419,0.012526367,0.07580173,0.0119389305,0.02502357,-0.076437764,-0.008190049,0.03539494,-0.064475104,0.021413004,-0.023324626,-0.089203976,0.0048269476,-0.024952456,0.03785682,0.03211264,0.026642041,-0.06880825,0.019662457,0.0009103807,-0.063159846,0.024312051,0.05677743,-6.0080125e-05,-0.026668122,-0.030187335,0.13529149,-0.0807099,0.016257916,-0.011801418,0.00048598353,0.03258386,0.06194203,0.057036772,0.021826973,0.15897453,-0.084125526,-0.015095375,-0.03582049,0.013207204,-0.052167498,0.0084736375,-0.04683131,0.054258168,-0.0742694,-0.015323687,-0.012924084,0.054469477,0.041796304,-0.0846043,-0.042765968,0.002246716,-0.06562292,0.015988879,-0.0765857,-0.040243436,0.00464868,0.019182583,-0.15748242,0.052364614,-0.021804472,0.020072285,-0.018938838,0.086660825,0.053259283,-0.033967223,-0.080016345,0.06456277,0.015018983,-1.9138033e-33,0.023298744,-0.031919286,0.04275517,-0.04700092,-0.010033112,0.06719498,0.075936586,0.08143596,0.07259655,-0.032939646,0.09608446,-0.009727152,-0.013864979,-0.07379008,0.026558094,0.05827821,-0.038466368,-0.028107006,0.034149375,0.060791705,-0.025445942,0.0782262,-0.053323183,0.038178217,-0.009563507,0.03730764,0.08028663,0.03585962,0.042306498,-0.005236052,-0.07282387,0.0034995396,-0.059291102,-0.018708773,-0.07110667,-0.04469951,0.0018539735,-0.09648553,-0.018159684,-0.045793686,-0.0552921,0.016036212,0.020708064,0.08230847,0.052408863,0.11095963,0.04604102,0.03652549,0.04614443,0.013439778,-0.008844803,-0.04424603,-0.016828682,0.09671934,0.015175382,-0.02303854,-0.00368301,-0.010379753,-0.07534273,0.010779409,8.207505e-05,-0.008660751,0.005485475,-0.07760352,-0.002355926,0.06921418,-0.028255155,0.025584554,0.046543233,-0.013206514,0.067753196,-0.04799336,-0.071361445,-0.08016963,-0.041931104,-0.03622771,-0.048248168,0.064378224,0.009883033,-0.01926497,0.035998903,0.022647817,0.0031793758,-0.0073280754,0.052504204,0.023727152,0.024879498,0.10362,-0.043160595,0.05536856,-0.043084748,-0.005408865,-0.11957032,0.06634114,-0.007925858,-2.565608e-08,0.07448425,-0.06829004,0.032850478,-0.020946853,0.027477631,-0.0040879487,0.02930548,0.04942839,-0.015801657,0.06789227,0.0044508576,0.054811977,0.04709478,-0.03956243,0.013355127,-0.031958744,-0.08646454,0.020463414,0.001978875,0.010230597,-0.02767071,-0.020942332,-0.006718235,-0.009874488,0.015762763,-0.0015298947,0.04931025,0.005157126,-0.026834842,-0.024910338,0.014943879,0.03258698,-0.013242251,-0.04261231,0.01347774,0.03344594,-0.08475457,0.0012795007,-0.020349523,0.04768924,0.053289205,-0.021877136,-0.039018642,0.014654927,0.04497853,0.010622287,0.054738097,-0.009668944,-0.015244216,-0.020853492,0.009763501,-0.013634297,-0.010546398,-0.04317373,-0.050923962,-0.020782007,-0.025052713,-0.12300405,0.032812383,0.007279055,0.08329442,-0.11810182,0.13934849,0.0812509 +3.1.6.15,The enzyme from Flavobacterium heparinum also hydrolyses N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts only on the disulfated residue.,384,0.99999994,-0.055913568,-0.10465585,-0.12488845,0.003293111,0.048722208,0.03201915,-0.060842197,0.04708085,0.031108052,-0.016002037,-0.048977543,0.059877608,-0.11696512,0.04417311,-0.076492175,-0.03815504,0.01064676,0.025246141,-0.027778314,-0.040279426,0.09366592,-0.039097097,-0.0088010905,-0.05590109,0.04657547,0.03424471,0.07141434,-0.015478017,0.02769006,-0.055974893,0.036108118,-0.06063355,0.055001225,-0.07987334,0.022588598,0.07435076,-0.023708977,-0.09302657,0.040322896,-0.019528741,0.08754912,0.03771119,0.014482906,0.0046397056,0.028443327,-0.06272926,-0.049114358,0.08862307,0.06525502,0.017090464,0.030302424,-0.0641526,-0.038387455,0.048402403,-0.0468359,0.018743487,-0.044931903,-0.04866161,-0.038740374,0.028993968,-0.036565144,0.06868308,0.09010954,-0.02377907,0.056841977,-0.06671602,-0.010417571,-0.03926664,-0.05911146,0.0035626818,-0.011872453,0.036586568,0.04847671,0.09500512,0.008747409,0.009006655,-0.06419566,0.052270886,0.0772687,-0.032297783,0.018404653,-0.03280404,0.024642128,0.146252,-0.019181391,0.005671644,-0.095832475,-0.009078695,0.06159906,0.021691222,-0.027066803,-0.0060507758,-0.030200606,-0.03537398,-0.04530162,-0.021094322,0.019667115,0.07990967,-0.05229223,-0.029053688,-0.007896375,0.0545863,0.010868416,-0.06336591,-0.05883738,0.046202656,-0.04038595,0.12606627,0.054195024,-0.0104909735,-0.03873888,-0.0040061185,0.0061585475,-0.060942646,-0.052403938,0.021202862,0.022476133,-0.055761203,-0.1044766,-0.025201222,-0.029353399,0.04080689,0.112160616,0.11510655,-0.005721259,-0.034263693,-0.015986266,3.0982468e-33,0.059850585,-0.059830472,0.02274564,-0.042250287,-0.041273743,0.010243166,-0.022841254,0.009732031,0.031189876,-0.019268306,-0.0908454,-0.009112517,0.019578775,-0.010253716,0.011743695,0.04214422,0.019479468,-0.056845814,0.055737805,-0.006768879,0.085758336,0.027373075,-0.047660574,0.047685716,0.018271057,-0.007826103,-0.08043085,0.022802705,0.07213827,0.017240731,-0.023831459,-0.07926905,-0.06120266,0.053069,-0.020331688,-0.0031732023,-0.080077685,-0.0799964,-0.02100306,0.04134607,0.04894995,-0.03761983,0.057166062,-0.0750391,-0.03074943,-0.017838592,-0.0023860524,0.07614983,0.02041354,0.029769013,0.10087522,-0.009191607,0.13601483,0.007970208,-0.07826376,0.06220404,0.008955963,-0.027379615,0.03999935,0.063515544,0.006905626,0.04074507,-0.022202447,0.031980004,-0.08083371,0.02110327,-0.0072813625,-0.02022364,-0.020406429,0.0997649,-0.072127774,0.002708105,0.021019448,0.035867702,-0.008624266,-0.072494686,0.027700648,0.042992335,-0.024906378,-0.009426463,-0.018232435,-0.03901993,0.005133163,0.045036204,-0.04666689,0.100833416,0.0067618117,-0.06050825,-0.02677566,0.022337474,0.038969614,-0.045063015,-0.07812817,-0.0023790738,0.019497374,-3.972486e-33,0.030423297,-0.09168856,0.0062371404,-0.0026927087,-0.06287815,0.033372387,0.016525479,0.013254814,0.047996603,-0.02905196,0.019527603,-0.03256209,-0.0484265,-0.052930187,0.008632137,0.05622565,-0.01594962,0.1050022,0.004090926,-0.042596374,-0.058018964,0.05165619,0.072076924,-0.024840571,0.097578734,-0.03608701,0.013950597,-0.0118019,0.013135464,0.09054959,-0.021213941,0.039840937,-0.05183434,-0.078419514,-0.020168949,-0.009460319,-0.051712204,-0.07708664,0.026896657,-0.047566373,0.011255402,0.018910505,0.042998,0.1000402,0.034590896,0.09635187,-0.11115481,0.045911323,-0.021303905,0.028053299,0.0011231684,-0.024974458,0.0008803627,0.07792857,0.052155152,0.06605668,0.066281654,-0.0072342334,0.007081028,0.0035979256,-0.017733812,-0.054323856,-0.04592578,-0.024963435,0.038306173,0.04790982,-0.0007840469,0.08866177,0.017732153,0.016755655,0.050180383,-0.073128186,0.02286177,0.11942366,0.05934339,0.0075325943,-0.050799973,0.048312165,-0.024346031,-0.042980567,0.00044581885,0.001942914,-0.0019438907,-0.07420867,0.017552365,-0.047973786,-0.033972893,0.14122488,0.00451779,0.0850977,-0.0017898876,-0.028100744,-0.05496511,-0.026999637,-0.03236001,-3.5641058e-08,-0.005160879,-0.028017288,0.05435092,-0.030280717,0.015552677,0.053922307,-0.0071564456,-0.0069175744,0.024935525,0.0050521614,-0.023295773,0.07561154,-0.053563103,-0.0388917,-0.054702114,0.015403116,-0.025883166,0.013291586,-0.02897655,0.0028717148,-0.101668306,0.009190012,-0.08389379,0.058108315,0.026796784,-0.042597286,-0.03575663,0.012318727,0.026534516,0.03358554,-7.9743375e-05,0.017090335,-0.0029590419,-0.089782275,-0.103289925,0.038870614,0.009682199,-0.047983848,0.013696204,0.010984743,-0.02864731,0.057819758,0.016887886,-0.006191442,0.023093048,-0.0025315848,-0.027894732,0.04386235,-0.0063216947,0.0018014787,-0.050402705,-0.008054255,-0.059967045,-0.06773051,-0.0621271,-0.06602975,0.035885878,-0.1206056,0.028091282,-0.06191061,0.009036694,0.010679605,0.19944234,0.04549897 +3.1.6.16,"Highly specific; does not act on monoethyl sulfate, monoisopropyl sulfate or monododecyl sulfate.",384,0.99999994,-0.00541354,-0.11655758,0.041761786,-0.06466539,-0.00897138,-0.009645125,-0.04392455,0.013498762,0.008793332,-0.039654974,0.0462548,0.04921696,-0.0407837,0.11125308,-0.0012678565,0.06330624,0.03915157,0.02005279,0.00974908,0.02738306,0.08821217,-0.010488189,-0.025438027,-0.038635187,-0.03398823,0.04096284,0.027481804,0.06738744,0.022091191,-0.031188278,-0.07099502,0.020847384,0.024103511,-0.04204161,0.041266512,0.082069844,-0.11592369,-0.027438736,0.081300445,0.017686855,0.04993926,-0.053519063,0.0017932714,-0.05985787,0.027399335,-0.09726578,0.009892789,-0.039079797,-0.018825298,0.024510857,0.0018673727,-0.0671946,-0.027398257,0.08420432,0.010138541,-0.02359857,-0.07866895,-0.02009057,0.015239885,-0.02432333,-0.06589817,0.0011271724,-0.04935183,0.007845339,0.06318942,0.060609203,0.03596409,-0.10217878,-0.0027666835,-0.034836918,-0.07702486,-0.02350833,0.028486092,0.114447124,0.017347319,0.053605016,0.022538045,-0.061865266,0.046935495,-0.07093385,-0.04775572,0.03760392,0.05096845,0.031966392,0.0773368,0.020970864,-0.014181234,-0.0050836457,0.010759308,0.052930664,0.0071307067,-0.029408602,0.026597047,-0.056378797,-0.030482536,0.03475449,-0.0012363971,0.07960612,-0.015631277,0.0023525546,-0.013034545,-0.039534573,-0.08832595,-0.030361068,-0.039318755,-0.030065509,0.008350924,0.004500784,-0.039776254,-0.027841898,-0.09106317,-0.03727193,0.06310262,-0.076772265,-0.12392706,0.050180208,0.056382667,0.01540819,-0.06007229,0.025013996,-0.042500548,-0.04937951,0.032685354,0.027425067,-0.08362879,0.07779069,-0.059781987,2.916976e-33,0.09595788,-0.008797065,0.08591528,-0.015443032,-0.06121206,0.036507916,-0.057756525,0.0174825,-0.015294736,-0.020439982,-0.0038203353,0.021688953,0.017937258,0.061152976,-0.0041302238,0.06954732,0.017373927,0.014912771,0.039796628,-0.083775505,0.00026374674,0.10822215,-0.084055014,-0.010176269,-0.076879114,-0.059689406,-0.009543514,0.009374475,0.03128456,0.021068022,-0.006897337,-0.08009906,-0.012262214,-0.008601458,0.024745181,0.09290256,-0.11501636,-0.036847934,0.0031991364,0.019556308,0.07750306,0.04818762,0.008870164,-0.02469181,0.047043078,-0.054030966,-0.07829882,0.041818622,-0.02917994,0.036230054,0.033126425,0.03729679,0.01029265,-0.014275751,0.004900141,0.048816364,0.0026028736,-0.009926004,0.03254375,0.052313205,-0.014359583,-0.0077078915,-0.008436519,-0.08873527,-0.0015001139,0.038368907,-0.048102014,0.049193993,-0.040635284,0.023151062,0.010013211,0.04640244,0.023204885,0.08294021,0.016060656,7.109208e-05,0.024445392,0.010845648,0.095807165,0.011734985,-0.12516877,-0.0066709127,-0.0047674053,-0.016309692,-0.14212455,0.060882963,0.042344708,-0.07270743,-0.028405294,0.009618975,0.031374086,-0.04840275,-0.1157963,0.021914745,-0.049502824,-5.8412654e-33,-0.030474724,-0.07649999,-0.02277196,-0.023271503,0.009039066,-0.011379582,0.06882168,-0.018071247,0.04870924,0.015438908,0.13640803,0.0030995922,-0.04830885,-0.05344316,-0.029083742,0.09416991,-0.042650793,0.06022024,-0.04239002,0.0132578155,-0.013633375,0.11175659,0.0343275,0.13848114,0.069633976,0.015717695,-0.028663527,0.009475628,0.01858057,0.09467396,-0.03671871,0.047634296,-0.08133744,0.0094345035,-0.042026855,0.0153493555,-0.051483225,-0.060994077,-0.032951392,0.003075606,0.004072983,-0.045302093,0.013499406,0.1263361,0.029985018,0.04279751,0.0093077365,-0.0041920994,0.08086804,-0.0067661493,-0.059908174,0.00031448703,0.042247027,0.0873347,0.019470608,0.057810787,-0.046735108,-0.05311024,-0.07553063,-0.005901814,-0.024029644,0.02939184,-0.014921995,-0.0908764,0.025670834,0.02068113,-0.026688175,-0.06950043,0.032289498,-0.102311134,0.0688284,-0.040816806,0.011796002,-0.076834045,-0.047796164,-0.0865297,0.05945053,-0.03823488,-0.09862112,0.014307665,0.040824007,0.0922354,-0.059267174,-0.012463595,-0.012967685,-0.00997059,-0.07583635,0.023641657,0.0037309125,0.0029829438,-0.0366937,0.056927826,-0.045979187,-0.017215641,0.019005705,-3.0201107e-08,0.017474877,0.035149246,0.0629602,-0.03406359,-0.041791964,0.032471254,-0.006900509,-0.05448313,-0.005051423,0.05978348,0.010826515,0.062211312,-0.005711795,-0.010782173,0.03727322,-0.07681988,-0.015060973,0.07133324,-0.071937114,-0.100495905,-0.09060486,-0.011719858,0.005736889,0.04685479,-0.024910979,-0.05962397,0.032947656,-0.07712564,-0.05383827,-0.038292482,0.027080065,0.05724476,-0.04067605,-0.028534885,0.0150066875,0.13488072,0.010951648,-0.012182682,-0.04902906,0.057164602,0.009990516,-0.05592447,-0.0331431,0.06956712,0.045399018,0.015016518,-0.006434213,0.045243353,-0.025704764,0.01862042,0.008775347,0.005777056,-0.024968565,-0.032818425,-0.06298103,0.014313054,-0.0005784303,-0.027140066,0.044088487,-0.044849064,0.09350618,-0.074918136,0.1220475,-0.016644532 +3.1.6.17,Highly specific.,384,0.99999994,0.019630184,0.020524966,-0.0230152,-0.020047296,0.024092974,0.0406417,0.01810513,0.021626374,-0.087683104,0.025034381,0.049981266,0.07347534,-0.03327476,-0.005415522,0.014728936,-0.03250771,0.14855814,-0.08265671,-0.08764366,0.0051208395,-0.008628811,-0.0033209734,0.062129613,0.01479178,0.017975545,-0.021437574,0.018815499,0.06956224,-0.014540581,-0.033472992,0.00985978,0.035012644,0.04077409,0.016629338,-0.074339546,0.12060398,-0.06889379,-0.0019449351,0.07577824,0.0128357,0.026173191,-0.012304484,0.034301944,-0.008898489,-0.0014370269,-0.022970771,-0.039906796,-0.016499123,-0.04642852,0.008880071,-0.009253621,-0.06546112,0.04591092,0.016099604,0.032182988,-0.065169394,0.03340078,0.011741369,0.071402214,0.032650072,-0.004116478,0.035665374,-0.08813003,0.021229845,0.1509717,0.0002472862,0.006332941,-0.046821017,-0.03000914,-0.02007239,-0.05246243,-0.040659763,0.027719542,0.009111694,0.07351445,-0.05729846,0.04702543,0.0064067594,-0.015810262,-0.056710877,-0.039893474,0.04909444,-0.0063509145,-0.009688946,0.08913302,0.053284056,-0.024151355,-0.029503722,-0.016472684,0.016280608,0.012094162,-0.07541018,0.11545992,-0.04950364,-0.030986318,0.0024644723,0.042414233,-0.10705784,-0.016860437,0.08021278,0.00860762,0.004037125,-0.03389221,0.050065465,-0.008436746,-0.060979486,-0.047801893,0.054549146,-0.06995602,-0.090007484,-0.11495861,0.0024508026,0.024528276,-0.033106238,-0.042515025,0.05307322,0.023206132,0.023664039,-0.012510923,0.039957467,0.026200978,-0.00594072,0.014255891,0.0049632443,-0.08309666,-0.032914195,-0.073286496,-7.926854e-33,0.03455006,-0.031404287,0.014410953,0.16132574,0.006539816,-0.0012397327,-0.0030263695,-0.012293285,0.013739783,0.067143,0.040282838,0.028888106,-0.07640751,-0.00097101065,0.07610626,-7.87875e-05,-0.08878439,0.058396786,-0.019405626,0.0017028035,0.019590734,0.030960713,-0.037802022,-0.04255902,0.029849818,-0.03250836,0.022277417,0.013941744,0.08840643,0.01628505,-0.061007418,-0.003636679,0.009472894,-0.06365878,0.073859066,0.029568287,-0.010664959,-0.051574916,0.020352978,0.023539122,-0.03575704,0.02146051,0.0051506995,0.09166367,0.04022605,0.033915803,-0.020297216,-0.010514895,-0.10557859,0.017497253,-0.10106621,0.021576107,-0.047632392,-0.03696988,-0.010676392,0.026443284,0.019515676,-0.0055166516,0.0785784,0.013454503,0.013761928,0.12697288,-0.09642051,-0.010007327,-0.07321037,0.058839895,-0.03780467,0.040001158,-0.006584064,-0.011659435,-0.05025824,0.035931997,0.19829985,-0.063189216,0.0035671045,-0.011519132,0.030885028,0.09217766,-0.029138278,0.0038970336,-0.06267852,0.06740324,-0.012650777,-0.004273909,-0.010017325,0.010221874,0.06546703,-0.108032525,0.0076424284,-0.03148979,-0.0564091,0.0041891793,-0.04870975,-0.112549126,-0.05134836,6.412181e-33,-0.04432546,0.009828455,0.042573765,0.059921816,0.09757311,-0.042594142,-0.07790132,-0.0018870387,-0.07278392,0.06629037,0.004876445,-0.0432753,0.06928215,0.00031821025,-0.04232126,-0.046658494,0.028597761,0.062944874,0.0083120745,0.017700948,0.023329148,0.013159454,-0.055838257,0.069176435,-0.072506346,0.02255539,0.005077847,0.009823019,-0.06306149,-0.06425466,-0.011728379,-0.09319706,-0.07560494,0.060201306,-0.09963827,0.05960445,-0.045183856,0.02656103,0.018564759,-0.006812521,0.092576146,-0.074929155,0.012449469,0.099080816,-0.071695164,0.0981975,0.011928692,-0.03380255,0.065547206,0.041073408,-0.13639298,-0.011017294,0.063445695,-0.034465868,-0.026307618,0.025647262,-0.015222279,-0.00776089,-0.008022891,-0.024942756,0.00043230207,-0.018748077,-0.030467527,0.03667369,0.020187015,0.04229571,-0.024786936,-0.07082783,0.04597465,-0.032074668,0.009900857,-0.06623191,0.013014218,-0.031125097,-0.13092577,-0.02688007,0.018633615,-0.003443203,0.0005642689,0.039134625,0.032391503,-0.022759462,-0.046837334,0.055766605,0.082204774,0.05723746,-0.06000702,-0.0021942141,0.07709214,-0.074506976,-0.0339119,-0.09277062,-0.03481143,-0.05412553,-0.009034519,-1.597169e-08,-0.03902775,0.070468016,-0.019455398,-0.009087524,0.023859533,-0.011962539,0.030921767,-0.012907053,0.0037944391,0.0391847,0.011287703,0.062478796,0.06302239,-0.01285154,0.07395657,-0.013552048,-0.017470121,0.05409657,-0.088913724,0.035792217,-0.027000815,0.04636564,0.08569034,-0.047154877,0.051179532,-0.010523361,0.058381774,0.054288268,0.009419741,0.027628561,-0.021505713,0.0030071926,-0.016405545,-0.036033046,0.047253825,0.07232611,-0.02523354,-0.029568175,0.07488461,-0.06413469,-0.02512882,-0.019198509,-0.014097056,0.09558656,0.067996286,0.012986802,0.0065120235,-0.0055387574,0.028456492,0.052861493,-0.047109302,0.06943612,0.010978891,0.05891871,0.051110785,0.030609403,0.0015038289,-0.06334439,0.03703199,-0.043403536,0.13312547,0.0719006,0.025956877,0.031312965 +3.1.6.18,Does not act on iduronate 2-sulfate residues (cf. EC 3.1.6.13 iduronate-2-sulfatase),384,0.99999994,-0.06561649,-0.16029191,0.0060304245,-0.04246527,0.025924692,-0.02702998,0.04797431,0.04482671,0.047446776,-0.021469114,0.0632053,0.022862015,-0.06296286,0.043267272,-0.08920045,0.08424377,-0.038252264,0.0058179772,0.02007948,-0.011930165,0.07262342,0.003144655,0.010892433,-0.0458461,0.0051978817,0.0813342,0.037815325,0.0051012696,-0.02144672,-0.025631515,-0.018163476,-0.054798193,-0.079760306,-0.04293033,0.058919117,0.046780452,-0.06610313,-0.104083,-0.053963207,-0.04620356,0.143445,0.010917289,-0.025492478,-0.051548444,0.0591601,-0.03192034,-0.0055960137,0.042305633,-0.03135406,-0.045929458,-0.05207219,-0.0859575,0.02071426,0.04561056,0.013614874,-0.004878372,-0.06125229,0.04563652,-0.019433783,0.045462303,0.008933043,0.03752071,0.0454966,-0.09296161,0.016428724,-0.05392335,0.06182674,-0.06589463,-0.055031262,0.007693133,-0.042806953,-0.026578689,0.016323995,0.03417005,0.05414419,0.040696155,-0.031018669,-0.052399036,0.06637424,-0.13876641,-0.030899918,0.0025403567,0.0833396,0.039730202,0.0064752763,-0.021334525,-0.006883946,0.036539875,-0.006278366,0.0773651,0.06252339,-0.039328415,-0.06936479,0.005280559,-0.04495122,-0.05144671,-0.0031385631,0.15952198,-0.03967608,0.0034082476,-0.024855856,0.06784719,-0.08170504,-0.12313873,-0.05669255,0.039759807,0.047764458,0.046881758,0.01229686,-0.01397287,-0.012957129,-0.021512946,0.06765794,0.028721169,-0.014559458,0.12274904,0.08544363,0.019574253,-0.048911,0.011249733,-0.05564317,-0.021570707,-0.03692992,0.021286402,-0.09218512,0.020695118,-0.1327556,-2.1692712e-33,0.081262216,-0.011324236,-0.010667603,-0.026434077,-0.06902919,-0.019352354,-0.08751043,0.0054287794,0.013427366,0.053805713,-0.049791288,-0.08909858,0.019467788,-0.0021187312,-0.04519514,-0.026920892,0.044117056,-0.011323227,0.05448669,-0.10462103,0.038773842,-0.0039788554,-0.07265489,-0.04135628,0.036694996,0.033016227,-0.037872918,0.005113845,0.105680935,0.03255837,0.048439573,-0.11373944,-0.04298164,0.0022165948,0.042792495,0.00046883873,0.010661343,0.011083547,-0.026926467,-0.025071435,0.033091642,0.017648406,-0.0008176646,-0.04043325,0.03652703,-0.024408324,-0.0004778483,0.12620346,0.061905816,0.008497354,0.0058010356,-0.055660147,0.08114321,0.015969925,-0.015082651,0.0028095252,-0.043312892,-0.020091938,0.06666629,-0.0033238202,0.029397482,0.044418186,-0.09353198,-0.07060879,0.009049053,0.09211054,-0.05569268,0.041132007,-0.025500527,0.03538392,-0.0011120669,-0.030917855,0.0058639483,0.033867296,-0.004244379,-0.04777947,-0.0062117707,-0.008234525,-0.014018535,0.04763817,-0.032202914,-0.010973435,-0.010177234,0.007895973,-0.043961283,0.0642344,0.06294942,0.06071678,-0.040462524,0.035987962,0.06154291,0.0065417676,-0.018340519,-0.018062484,-0.023054916,-2.5868767e-34,0.011027041,-0.0051263343,-8.6366286e-05,-0.033055928,-0.036621965,0.013835449,0.022371508,0.033230107,0.06496166,-0.07814284,0.044551566,-0.02903094,0.004719096,-0.02346142,0.054030325,0.011987163,-0.13761164,0.038732573,0.05081582,0.022690525,-0.018374538,0.12955077,-0.008659528,0.108345844,-0.025220657,0.021469768,-0.007900831,0.036509138,0.04050049,0.10099822,-0.0016964063,0.023646561,-0.07327635,-0.05494915,-0.06242658,0.0026585113,0.010116463,-0.09184475,-0.05121882,0.035963833,0.036370527,-0.032617077,0.018985605,0.17645049,0.052919764,0.016396847,0.03468328,0.07104774,-0.036754873,-0.045804486,-0.031243833,-0.0089424895,0.012874207,-0.008868546,0.01952468,0.05474801,0.054551903,-0.03243938,-0.09109951,-0.021119148,-0.047236975,-0.039833024,-0.02060859,-0.09397064,0.045561083,0.04175686,0.03485655,0.03927647,0.09640759,-0.06599623,0.028356524,-0.015770862,0.00045361597,-0.09746828,-0.032636784,-0.024979794,-0.075423434,0.076314636,0.0333249,-0.074145995,0.042282052,0.06734829,0.0033269979,-0.07468269,0.07659847,0.033059347,0.0023962385,0.10520434,-0.06432857,-0.003775759,-0.034449022,0.004106897,0.01823678,0.08431343,-0.045048278,-2.981967e-08,0.018768113,0.06883556,0.055585973,-0.030405346,0.014612844,-0.043632902,-0.0084391255,0.03980734,-0.035354473,0.05667064,-0.018081075,0.038516752,0.015442872,-0.02296317,0.07073885,-0.03584601,-0.017951848,0.07322659,-0.063598104,-0.053647734,-0.025665523,-0.06063414,-0.08820244,0.020670753,0.003985861,-0.09869858,0.03327067,-0.032327693,-0.079645194,-0.022846531,0.012969768,0.08088129,-0.012805987,-0.035124455,0.023614692,0.021561088,-0.019973729,-0.041125502,-0.01558563,-0.02147169,-0.010574644,0.005770407,-0.006543021,0.01660816,-0.009162195,0.032899424,0.09388331,-0.0029094077,-0.025959544,0.033336423,0.017446183,-0.029327534,0.02463674,-0.03676068,-0.019680645,-0.0016510942,0.0021389867,0.00020771315,0.05155314,-0.019884158,0.09000317,-0.038411632,0.01797776,-0.056149635 +3.1.7.1,Farnesyl diphosphate is the best substrate tested to date.,384,1.0,-0.071022585,-0.035776723,-0.014039694,-0.06096454,0.04632953,-0.015293461,-0.04874748,0.119992085,-0.04111725,-0.009757776,0.004486402,-0.009061872,-0.10385695,0.117729604,-0.011366058,-0.021221638,0.072933726,0.010745231,0.14026313,0.020541385,0.03830178,-0.048296254,0.03366795,-0.038124125,0.00030280964,0.049491275,0.03141774,-0.0061641997,0.05207481,-0.0756336,-0.03880346,0.067035876,0.015042721,-0.0772041,0.0001622768,0.06579553,0.0029470439,-0.08801258,0.012479249,0.011618383,0.03744329,-0.05170311,0.099098206,0.018395804,-0.038992602,-0.017814986,0.056797314,0.012497134,-0.0022806677,0.012055896,0.0027297642,-0.06549581,0.009602276,-0.042458292,-0.015335042,-0.074697234,-0.10315133,-0.012214544,0.016482959,0.065457225,0.021028966,0.003968087,-0.063197374,-0.06616848,0.047289405,0.016811939,0.030153569,-0.034944005,0.08675441,-0.019137839,-0.11225375,0.017465362,-0.029440409,0.06681582,-0.016150191,0.09721883,0.06372554,-0.041572094,0.03244078,-0.050568234,-0.029517312,-0.010464871,-0.020538678,0.041488744,0.113947675,0.052103058,-0.032633554,0.032352824,-0.010194856,-0.026540512,0.027944604,0.0900696,-0.04929586,0.027979469,-0.057076644,0.07426927,-0.013282083,0.009644553,0.0062747574,0.008783636,0.06450972,0.04908145,-0.0425125,-0.028410697,-0.029769583,-0.038580224,-0.026489275,-0.0089425165,-0.02223432,-0.059920687,-0.021102095,0.09832634,0.02439843,-0.0065777446,-0.06758729,-0.042982176,0.021656275,-0.013900449,-0.012310223,0.047809973,-0.053756543,0.0075652646,0.018306153,0.07275892,0.011855449,0.0039135646,-0.0025969779,-4.2885514e-34,0.035870943,0.09982298,0.043697573,-0.037547745,-0.10035917,0.011365021,-0.04993876,0.024420347,-0.027323252,-0.01709216,-0.019779908,-0.06517714,-0.026531013,-0.00251789,0.0372825,-0.04990533,-0.049435925,0.027516698,0.055636067,-0.0507666,-0.04088823,-0.03944002,-0.02925146,-0.043963805,0.09012269,-0.02445464,-0.016653977,0.019686239,-0.008388379,-0.010265938,0.071536206,-0.0699745,-0.027064411,-0.03172786,-0.0285346,-0.033138875,-0.13841638,-0.048322324,-0.012018127,-0.012207091,0.026899798,0.022451237,0.06812206,0.016290499,0.09293651,-0.07895952,-0.071610086,0.045403715,0.040057678,-0.05465821,0.018296836,-0.028797822,0.027162174,-0.035113744,-0.08746994,0.010906231,-0.0029385546,-0.031900093,0.019043054,0.0772312,-0.003765559,0.053575747,-0.057791196,0.0548337,-0.040708784,0.031137649,-0.05309745,-0.01560937,-0.060392078,0.07273443,0.056870658,-0.049911372,0.06726075,0.015356615,-0.06904635,-0.024224041,0.008188054,0.03245047,0.06672773,-0.01095017,0.11279442,-0.042740606,-0.067655735,-0.024591547,-0.120807424,-0.00036072574,0.027694322,-0.03956154,0.0371886,0.10724642,0.01874626,-0.103021465,0.019657297,-0.035776816,-0.04470928,2.1264998e-34,0.09144148,-0.06779118,0.026259907,0.033945676,-0.005271445,-0.04846688,0.10985791,-0.040785428,0.010722201,0.013768711,0.06327846,0.028190507,0.046779428,-0.041374866,-0.03176336,0.12145832,-0.030327568,-0.04831844,0.06657927,-0.03139906,-0.052407023,0.09365214,0.07175022,0.11065378,-0.0062301164,-0.00889931,0.055404384,-0.011156805,-0.05863435,0.07524706,-0.056533907,0.007962802,0.008478639,-0.056435082,-0.012007491,0.015382099,0.039860886,-0.043995813,0.03248936,0.00716234,-0.003168152,0.101993434,-0.020515526,0.04512261,-0.019047102,0.10984688,-0.021850133,-0.046836134,0.009830944,-0.025349306,0.0017286822,0.022328343,-0.04547298,-0.043851916,-0.0065571065,0.02968146,-0.05905375,-0.034608845,-0.04777849,0.005019161,-0.059659302,-0.016819902,-0.020298753,-0.06739269,0.07726107,0.13355361,0.019225193,0.107519604,-0.021978727,0.023016056,0.09148373,0.050510846,0.04473616,0.03419332,-0.06869443,0.00688202,0.055819087,0.029413728,-0.00773564,-0.0183507,0.010966502,-0.0143928155,-0.09281738,0.031336017,0.04664767,-0.010028416,0.029086966,0.008797945,-0.029008586,0.02849529,-0.016644599,-0.059370425,-0.048356112,0.041072488,0.110492356,-1.9160199e-08,0.08564443,-0.055241443,0.03992068,-0.04810781,-0.07331792,0.049539436,0.054947216,-0.0037510812,-0.009756058,-0.05121445,-0.03605869,0.025711142,0.029825494,0.03317468,0.11528788,-0.034048613,-0.062961034,0.017658338,-0.085005544,-0.024170956,-0.04063187,0.055989385,0.059530422,0.0034218063,-0.057367917,0.01620433,0.05962238,0.039002754,0.023760082,-0.049582537,0.04834144,-0.0066377106,-0.018654982,-0.019868575,0.013361801,0.08649657,-0.04106744,0.019558197,-0.03178544,0.11666093,-0.072838515,-0.016991686,-0.081151485,0.051838003,-0.023090703,-0.009584229,-0.010518623,0.038814433,-0.027011866,0.02128507,0.03290091,-0.017426038,-0.025913535,-0.04249256,-0.075286694,-0.013670771,-0.06491359,-0.025871977,-0.041423976,-0.03648859,0.08086688,0.03441677,0.10367973,0.013971017 +3.1.7.3,A group of enzymes with varying specificity for the monoterpenol moiety. One has the highest activity on sterically hindered compounds such as (+)-bornyl diphosphate; another has highest activity on the diphosphates of primary allylic alcohols such as geraniol.,384,1.0,-0.001557129,-0.124999724,-0.027082637,-0.019306356,-0.03080004,0.036548533,-0.029529497,0.07133687,0.047768157,-0.05230291,0.04523243,0.013122972,-0.045836546,0.092079386,-0.016674249,0.029092299,-0.016279155,-0.031110302,0.013634725,-0.023761354,0.023403578,-0.05836708,-0.0010787576,-0.01643569,0.094857045,0.06092545,0.0033694096,0.010063149,0.095239125,-0.027522597,-0.045438584,0.040354118,0.07762688,-0.04961531,0.00975076,0.08181957,-0.05363648,-0.03130761,0.06287189,0.017164906,0.008470739,-0.02242514,0.005621778,-0.040269125,-0.043467462,-0.026195312,-0.013447793,0.008400605,-0.062198006,-0.012760982,-0.031223798,-0.04624087,-0.018887803,0.044476394,0.040967803,-0.0497608,-0.02226985,-0.044279933,-0.06322321,0.03127323,0.00605847,0.0020072649,-0.030509843,-0.01784582,-0.00084841135,-0.002894389,0.035130076,0.056931723,0.009305994,0.031933237,-0.11112911,-0.06306303,-0.020259848,-0.011191687,-0.058486454,-0.020484075,-0.006502623,0.036966912,0.006792821,-0.1679728,0.059777908,-0.025851356,-0.004575374,0.060590435,0.06354911,-0.0025617674,-0.06416959,-0.009795883,0.09761908,0.050727148,0.003250245,0.02293631,-0.031003468,-0.049663495,-0.03293139,0.09131796,7.2379546e-05,-0.03093335,-0.07952118,0.035732646,0.0794262,0.05919373,-0.070621155,-0.0041154735,-0.008656258,0.024704512,-0.037379242,-0.0692383,0.010982769,0.010474631,-0.014313262,-0.024909139,0.048289567,-0.048241224,-0.05727645,0.010541352,0.05388583,-0.004721187,0.005660846,-0.021839412,0.006214272,0.012668966,0.043981396,0.046003573,0.0054102675,0.044992886,-0.032846633,1.8199788e-33,0.08312933,0.025541695,0.0065208254,-0.016273106,-0.03115726,0.013131755,-0.042512376,0.064200096,-0.082514346,-0.03234119,-0.01309495,-0.008444523,0.02954898,0.07999921,0.029964194,-0.006025717,0.033033364,0.03919361,0.08294142,-0.05710361,-0.021351008,0.03907626,-0.04910021,-0.012609791,0.022278972,0.0014619146,-0.02408574,-0.006722501,-0.03663149,-0.011076385,0.038005844,-0.090897724,-0.06147443,0.03246157,-0.0081880065,0.021165814,-0.043987837,-0.048309468,-0.07600571,0.029290967,-0.042192634,0.04194813,-0.0214086,0.0028456217,0.07372135,0.0012270502,-0.07751291,0.06193255,0.012838501,0.008560728,-0.00071917975,-0.048266362,0.0006366485,0.002910588,-0.08275677,0.120894015,-0.028765453,0.042697765,-0.0012672251,0.049115196,-0.054941658,0.026561607,-0.099788524,-0.02391015,-0.02136491,0.03535274,-0.06437382,-0.052499857,0.03347052,0.1493928,-0.049661607,0.018027708,0.013833146,0.06953394,0.01321249,0.051749013,0.025574448,-0.013419315,0.04804698,0.020963388,-0.10131155,-0.054415982,0.027536586,-0.08865661,-0.110812515,-0.0052451054,-0.014319464,-0.08888242,0.005532129,0.023462854,-0.047027823,-0.010728547,-0.0024482168,0.056983326,0.0048355297,-3.776562e-33,0.085158885,-0.15494406,0.013863821,-0.06544219,-0.04797165,0.05744875,-0.007240116,-0.11045233,-0.05720533,0.018761868,0.049533475,0.01705591,0.06526239,-0.03874991,-0.008573116,-0.0004659135,0.003394575,0.12917146,0.09283825,-0.005669952,0.0040793503,0.1012661,0.033613104,0.1090932,0.029839236,-0.008832865,-0.044057984,-0.009032397,-0.02020991,0.08951305,0.030216662,0.009432624,-0.017929373,-0.0073053674,-0.010920504,0.11377178,-0.08795482,-0.0037364953,-0.011135069,0.065603495,-0.012444412,0.04229272,0.049319167,0.050322913,0.089395896,-0.0050410633,-0.16461888,0.0018712024,0.021955127,-0.08393387,-0.018018197,0.00962155,-0.0062977467,0.089421704,0.052324474,0.0021351532,-0.0054679993,-0.050696403,0.037836775,-0.06674416,-0.0075852703,-0.02710794,-0.08403972,0.0025261592,0.048095576,0.0037341053,-0.044179242,-0.014754478,0.033222392,-0.036053162,0.019465733,0.0050348523,0.040693745,0.009344187,-0.05144662,0.028640775,0.008212388,-0.09430563,-0.022183407,-0.060261272,-0.0021992885,0.039129786,-0.011342806,-0.008584361,-0.12868418,-0.036327314,-0.012023388,0.08665031,0.08510979,-0.027901463,-0.03709085,0.06598931,-0.09655886,0.017981816,0.047175203,-3.545411e-08,0.037048306,-0.0311012,0.011951446,0.007463259,0.0004679287,-0.011044519,-0.009498247,-0.0007670431,0.0034844393,0.050952755,-0.03757795,0.0627849,-0.018025752,0.03304014,0.06944438,-0.014429053,0.013834759,0.016556643,-0.046464823,-0.051738217,0.031058965,0.034438524,0.034178365,-0.011117972,-0.03244404,-0.12710151,0.020885361,-0.0012551463,0.0015557386,0.0030202314,0.008437209,0.026825538,-0.02243817,0.030888041,-0.005419525,0.09075649,-0.062766105,-0.041586384,-0.07698055,0.124595135,-0.016380936,-0.13708602,-0.09532641,-0.0031900788,-0.0064721336,-0.031417977,0.03935242,-0.025595121,0.018015996,0.020128516,0.014330401,0.013009394,0.043929633,0.023672234,-0.07240074,0.036713842,-0.10133634,0.012634395,-0.02866904,-0.09217896,0.09450083,0.03563937,0.1705512,0.023409 +3.1.8.1,Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.,384,1.0,-0.03352482,-0.085131526,-0.02043529,-0.047729753,0.02566302,0.075576685,0.09941394,0.013571963,0.03752223,-0.029638669,0.036205895,-0.014719609,-0.08999496,0.009433958,-0.0089171855,0.068570204,0.00012480408,-0.0012013536,-0.026093097,-0.019158619,0.078842044,0.019085106,-0.036208272,0.008610688,-0.0314412,0.007972681,-0.0047657653,0.031577248,0.011842721,-0.07845698,0.04826689,-0.0018322254,0.032897092,-0.02869967,0.039883442,0.06594588,-0.058169257,-0.07368137,-0.011082109,0.0034743447,0.0351268,-0.015824707,-0.09278109,-0.08841487,-0.059867162,-0.051543012,-0.010563516,0.012512228,-0.022290861,-0.014046219,-0.012024598,-0.027006948,0.009413811,0.03185337,-0.048988804,0.021383436,-0.09843762,0.08810857,-0.013308464,-0.059983857,-0.015424791,0.013952635,0.02199622,0.042579062,-0.07419994,0.029508661,0.08017057,-0.04487945,0.04984344,0.0012407831,-0.06783185,-0.10263106,0.00609339,-0.02903936,0.016337601,0.07691373,0.024918182,-0.11222275,-0.0042790268,-0.07029576,0.04502945,-0.11194349,-0.035375636,0.037335806,0.013533545,0.0357399,0.02455936,-0.029008808,-0.0072197,0.055639587,0.07675564,-0.0632731,0.026926627,-0.045042984,-0.004150637,0.05242813,0.0046374714,-0.02458741,0.031019071,0.020804249,0.048421312,0.07726822,-0.079132825,-0.08319455,0.02325103,0.038856085,0.021061512,-0.0263306,0.010228417,-0.0027847297,-0.07829875,-0.03245808,0.05931006,-0.02948634,-0.07461066,0.090183474,0.039982315,-0.0904906,-0.028904013,-0.050420523,0.05819896,-0.027964288,-0.014235828,0.044485062,0.0013480178,0.035960816,-0.0661035,3.532567e-33,0.065368205,0.031263925,0.044846173,-0.03525277,-0.012874897,-0.0315554,-0.10904949,0.06951476,0.006972253,-0.052953057,-0.08634472,-0.024740864,0.050855506,0.01905623,0.029796256,0.016963199,-0.014269231,0.09591361,0.072656825,-0.03184106,-0.022576105,-0.028407253,-0.05065048,0.031907167,0.011469367,0.026489139,-0.096150964,0.002385018,0.022754623,0.00061846315,0.06073669,-0.04371227,-0.057430804,0.08218974,-0.074099764,0.09181348,-0.032205027,-0.0555757,-0.021042932,-0.0031941263,-0.042443637,0.010279757,0.0045295213,0.0127111515,0.017869186,-0.13240111,-0.061843634,0.08290827,0.09000691,0.026257861,0.009950661,-0.042928793,0.10605859,-0.0031191034,0.060726736,0.024691561,-0.03589362,-0.017350877,0.07759698,-0.008553558,0.045613322,0.048515536,-0.07098132,-0.0021670547,0.040717397,0.06580666,-0.033301845,0.0025913846,-0.04965554,-0.0024867814,-0.07317176,0.029750489,0.05225909,0.031623147,0.04863433,0.01266133,-0.04650816,-0.06779231,0.028967772,0.085424334,-0.006051729,-0.058235753,0.042372975,0.026524011,-0.059776135,-0.0351979,0.043883014,0.015925283,0.042968597,0.028740996,0.011685047,-0.041280918,-0.112703785,0.023019264,-0.018228106,-4.622224e-33,0.07285412,-0.017282506,-0.028209377,-0.0337242,-0.039007742,0.07926401,0.01138181,0.015109708,0.028292393,-0.039475475,0.044459764,-0.05885852,0.12252676,-0.12882487,0.000995324,-0.031603076,-0.042362366,0.012351491,0.0684337,-0.0018847632,-0.05869466,0.015336128,-0.0055149407,0.0963132,-0.04447652,-0.028807014,-0.025502862,-0.028082553,-0.005002067,0.06499275,-0.008346145,-0.012766685,0.007777239,-0.052080728,0.049595173,0.089367,-0.018436654,0.04413463,-0.020646095,-0.022814544,-0.019345094,0.0076293224,0.05492198,0.05393074,0.04971105,0.092813924,-0.04802454,0.007442292,-0.02500286,-0.052572645,0.008399611,0.052564096,0.015874837,-0.025402065,0.14484674,0.044714604,-0.07362183,-0.08409257,-0.011087029,-0.002823307,0.011334938,7.339892e-05,-0.040305037,-0.031862125,0.003957457,0.07783299,-0.07788138,0.034708835,0.010816127,-0.025641587,0.09997595,-0.005687571,-0.0060347267,-0.0055651027,-0.046592947,-0.07853158,0.017464718,-0.06168922,0.028677952,-0.08450497,0.0696588,0.05929242,0.001524194,-0.11441738,-0.049428824,0.017074306,-0.03752278,0.040829837,-0.045527816,-0.019492056,-0.00913006,0.019041125,-0.020509513,0.072315246,0.054647576,-3.7524853e-08,0.06948215,0.043509733,0.080063134,-0.06622663,-0.00804598,-0.004028161,0.14123322,0.01564261,-0.022885503,-0.050740276,-0.0029990165,0.0023884522,0.095972635,-0.022192677,0.13258407,-0.02322953,-0.08309473,0.053235542,-0.073719464,-0.029185683,5.8567544e-05,0.012908606,-0.09824657,-0.060835294,0.060075033,0.0085134,0.09720976,-0.05125149,-0.03845714,0.0424485,0.016950626,0.024981834,-0.06006377,0.014237139,-0.031275284,0.072493196,-0.036195926,-0.02658186,-0.07352993,0.006489204,-0.061637554,-0.023707407,-0.08449887,-0.010098793,0.04862669,0.036644276,0.06384945,0.0053733746,0.007969655,0.0110424245,0.026064195,-0.038535602,0.031140136,-0.024976071,-0.073139675,-0.032053765,0.020362053,-0.030031433,0.017400993,-0.072518654,0.042766135,0.018189883,0.13386548,0.027960947 +3.1.8.2,Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase.,384,1.0,-0.020005975,-0.088541955,-0.00126479,-0.03603112,0.019692283,0.05086099,0.10601259,-0.04291958,0.04332131,0.0822538,0.009524659,0.029882295,-0.08477777,0.073089145,-0.05958907,0.02301068,-0.0066925874,-0.020029096,-0.002192973,0.016050216,0.080361694,0.03512433,0.05981268,-0.056714613,-0.0032092223,0.024953114,0.043250572,0.01836008,0.004899491,-0.020439966,0.0010921729,-0.044659533,0.015030937,-0.046898823,0.11386565,0.09536065,-0.11023591,-0.021497322,-0.08709069,0.041535363,0.052628763,-0.10043116,-0.0029591427,0.011573375,-0.024031168,-0.0056050406,-0.036209345,-0.024518678,-0.008222573,-0.08263403,-0.0123924725,-0.012232135,-0.020910924,0.015132442,-0.041941676,0.004256744,-0.059107438,0.09703212,-0.10652009,-0.079062864,0.020342272,0.028106712,0.015443717,-0.015631866,0.001182429,0.052875273,0.1014825,-0.05669394,0.0015731825,-0.0024787905,-0.024719022,-0.08346512,0.0061186417,-0.04430311,0.02603812,0.06106349,-0.03720728,-0.068986915,-0.030001756,-0.081143275,0.035072945,-0.033492845,-0.039875064,0.07170864,0.053000946,0.027208861,-0.046922926,0.0044957586,-0.03821929,-0.004715297,0.010092054,-0.013691921,0.04087916,-0.042385444,-0.07379137,0.032447375,-0.028240083,-0.045232505,0.0031292606,-0.009865373,0.01830235,0.0937834,-0.16293761,-0.022043113,-0.034175515,0.06833879,-0.02330474,-0.030895438,-0.003577343,0.025882589,-0.07322236,-0.021689683,0.010412459,-0.027567305,0.010573467,0.06270174,0.040395677,0.028517483,-0.027991565,-0.0027928792,0.004622386,-0.048088778,-0.065715194,0.07838981,-0.035208516,0.030692397,-0.12490246,2.3158067e-33,0.10654155,0.022275593,0.008172764,-0.059000462,-0.036571786,0.009010395,-0.03638605,-0.03372753,-0.060672708,-0.004306364,-0.040190026,-0.057852406,0.12301023,-0.06388943,-0.020820215,0.013008444,-0.020810002,0.0648863,0.13250434,-0.04883814,0.01587018,0.026733356,-0.026249066,0.075635724,-0.019886876,-0.014221632,-0.04822278,0.051299226,0.05751015,-0.012257366,0.023103375,-0.044306807,-0.10201871,-0.0005644031,-0.0091302,-0.034801964,-0.0854539,-0.018118104,-0.036832478,-0.025648598,-0.077151984,0.005068783,-0.0027461539,-0.007969923,0.022971839,-0.030880634,-0.09174797,0.06282393,0.08860935,-0.034447376,0.06357675,-0.051889908,0.07292918,0.034219764,-0.059401933,0.021406973,0.008403357,-0.04775644,0.0032954258,0.009729885,0.02537559,-0.01636953,-0.008257723,-0.045620263,0.0034518724,0.047831442,-0.034611758,-0.07810355,-0.025882553,0.012036784,-0.06532016,-0.025409307,0.01201157,0.088095196,-0.019871294,0.01848222,-0.027931625,-0.0052421903,-0.032050643,0.10713594,0.02473691,-0.09940047,0.0810904,0.038186688,-0.02705766,-0.05170041,0.033327654,-0.07168577,0.0931706,-0.013208647,0.077855945,-0.10530381,-0.024109984,-0.039826564,-0.011961065,-3.3192357e-33,0.07765141,0.029689187,-0.03464864,-0.029412828,-0.017318388,0.040201776,-0.0028500513,-0.058202967,0.04232054,-0.03755638,0.061901815,-0.02362933,0.04372482,-0.09630328,0.024363695,0.019891005,0.021500332,0.06003214,0.09800728,0.04990806,-0.03432881,0.012543386,0.028621353,0.096235074,-0.029192593,-0.0016825397,-0.004772758,-0.022319196,-0.027504055,0.030198526,0.031031204,0.047982294,-0.084185034,-0.085769944,-0.011413873,0.012805987,-0.032433257,-0.06696328,-0.026338544,0.0398599,0.059192076,0.012658576,0.1582837,0.061902717,0.051214565,0.013318901,-0.03539855,0.017960846,-0.10688432,-0.05249806,-0.00626919,0.11201689,-0.004419884,-0.010252981,0.12755662,0.076417394,-0.0009951406,-0.02339523,0.06985192,-0.010157751,0.03920785,-0.029506378,-0.0033042715,0.014207822,0.016449636,0.057869997,0.008346295,0.011897877,0.062005974,-0.010269678,0.020413645,0.025654474,0.09297356,0.06333415,-0.04264347,-0.02044101,0.0076802727,0.010329934,0.05129767,-0.018690882,0.009290911,0.06537181,-0.027503587,-0.059159,-0.029245,-0.021721257,0.023549719,0.0848244,-0.040907808,-0.06129411,-0.008947159,0.0028180345,0.048499264,0.078203574,0.064922795,-3.6566163e-08,0.091348976,-0.021284185,0.0065964134,-0.044339653,-0.0120681375,-0.041628487,0.13539322,0.069290414,0.008784143,-0.039928157,0.0059006643,-0.0044580763,0.11762828,-0.0070763133,0.0948628,0.048645344,-0.022134783,0.027519412,-0.063298166,-0.05421242,-0.003694557,-0.008156779,-0.11681773,-0.010965764,-0.0048394212,0.008693455,0.063664965,-0.03838351,-0.012364287,0.0145010855,0.0033599737,-0.0073991874,0.021444919,-0.017129619,0.037905473,0.06505264,0.009406681,-0.0320702,-0.026455633,-0.017116347,-0.08866286,-0.018533697,-0.04428111,0.028724667,0.056200128,0.06442427,-0.033322617,0.07802245,-0.025117116,0.014489868,0.014376177,-0.018406287,-0.05267732,-0.06730243,-0.09372982,-0.014693302,0.037580274,-0.02784737,0.03246109,-0.082211636,-0.008690065,-0.006916007,0.031096743,-0.051308658 +3.1.11.1,Preference for single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA.,384,0.99999994,-0.06093437,-0.03346039,-0.037647426,0.0017483863,-0.02693883,-0.0202318,-0.08140684,0.098580465,0.0029956265,-0.09586457,0.062667,0.076609366,-0.09263922,0.033860732,-0.03423232,-0.0182259,-0.028976623,-0.032381333,-0.008694123,-0.08512641,0.07877944,-0.016481869,0.0030124327,-0.009825586,0.0034182374,0.04003509,0.038959477,-0.008844533,-0.015073652,-0.08749186,-0.03438204,-0.0400361,-0.031624798,-0.018947205,0.10619814,0.05636863,0.070254765,-0.004826685,0.053088263,-0.015997885,0.04814313,0.043370735,0.02729375,0.046089757,-0.07672188,-0.046389155,0.05470493,0.027686292,0.013446011,0.04326789,0.071573876,-0.012127803,-0.017295197,-0.047358546,0.028324781,0.022902114,-0.0677326,-0.08035037,-0.027379582,0.051102474,0.030572252,0.03342541,0.014338468,0.011221528,0.059729576,-0.09054246,0.14003208,-0.03313591,-0.028797561,-0.022129726,-0.02301508,-0.027110457,0.009659818,0.011147261,-0.009754285,-0.03215476,-0.028938776,-0.084310725,0.060019456,0.11107239,-0.005746237,-0.09471734,0.014971055,0.023361323,-0.011562101,0.010379971,0.046890337,0.06915401,0.033695176,0.028881552,-0.036047976,-0.07027599,0.06394565,-0.058693547,-0.054391306,0.04477962,-0.028625485,0.026875015,-0.0023061563,-0.070767954,-0.0055307,-0.05122517,0.087949276,0.07698366,-0.039322946,-0.009078785,0.041833203,0.07130236,0.048691493,-0.021489354,-0.07727249,0.08570879,0.029135808,0.013175932,-0.14199966,-0.065001525,-0.021699592,0.0055380287,-0.063219786,0.041705795,-0.0053608357,-0.041175976,0.06886613,0.027062852,-0.047379397,-0.00651607,0.044622824,-4.5580753e-34,-0.013769856,0.028844563,0.059274614,-0.045060858,-0.03196341,0.001141163,-0.043841973,0.039258633,-0.123922355,0.016904157,-0.008505354,-0.020825827,0.02189354,0.075874284,-0.00588687,0.09653888,-0.020831775,-0.016573869,-0.0044536847,-0.011064103,0.0103382645,0.06536551,0.013280122,-0.019771978,0.02917466,-0.063094966,-0.027207058,0.055534467,0.080662176,-0.008847348,-0.037379872,-0.06778346,-0.029297447,0.06929742,0.092162475,0.058662213,-0.014967599,-0.051091786,0.056646135,0.06842861,-0.052558415,0.011333294,0.042424005,-0.109701924,0.059145235,0.03773386,-0.03461929,-0.03969891,-0.13662228,0.037727643,-0.010414016,-0.0028932944,-0.009482423,0.0048384466,-0.005371382,-0.010704708,0.046254978,0.018382514,-0.043199874,0.05134473,-0.05800202,0.08064924,-0.0280727,-0.08559699,0.011217372,0.020587362,0.040406335,-0.0030996525,0.019674512,0.059760805,-0.013146734,-0.04467152,-0.017045334,-0.0051921974,-0.027646653,-0.052119315,-0.013520674,0.0108401,0.054262117,0.029317414,0.0046387636,-0.0021350398,-0.027578248,0.0256955,-0.016013985,0.03615784,-0.041894995,-0.032279797,0.04289847,0.084366515,0.06887689,-0.03912929,0.018355941,-0.045230646,0.025299503,-2.0288434e-33,0.11799296,-0.09464861,0.05534384,-0.0003884773,-0.05201782,-0.027765406,0.043183163,0.015247511,0.01191708,-0.032066975,0.04256932,0.026830435,-0.08326939,-0.00044524137,-0.011974684,0.038605034,-0.03897348,0.021192452,0.005863551,-0.0022112292,0.014582798,0.058516517,0.0053930604,0.020273855,0.07471541,-0.040490184,-0.03910892,0.04883196,0.01466145,-0.023698458,-0.09655165,-0.019775923,0.027317818,-0.09689371,-0.045614935,0.05131281,-0.017912323,0.06761145,0.061626498,-0.020797066,-0.056061983,0.10992685,-0.036053933,0.054569304,0.023329502,0.08659484,-0.056955554,-0.0010746144,-0.00055338186,0.0047750203,0.00072100107,0.0060669295,-0.059473444,-0.059531502,-0.006781708,-0.054085832,0.049671624,-0.03414425,-0.046363883,0.009380014,-0.042530164,-0.057810772,-0.017158048,-0.00025297035,0.008658564,0.010779037,0.030529222,0.021500275,0.0040435093,-0.031571474,0.055308733,-0.03265755,0.06571134,0.05399567,0.051545206,-0.01470815,-0.1586614,-0.063417286,0.018731516,-0.042838626,0.04134768,0.009952294,-0.09477562,-0.014825265,0.13368292,-0.034415584,0.04479564,0.059800357,0.022452574,0.003994141,0.018984837,0.026310427,0.016713748,0.021070743,-0.005804964,-2.2753774e-08,0.042893697,-0.07847103,0.019618595,-0.09302909,-0.010457074,0.098660216,-0.012021435,0.011512596,0.1087763,0.012062791,0.013775944,0.080504596,-0.10640022,0.03492554,0.003781537,0.03856439,-0.13180503,-0.06265246,-0.009169527,0.08232075,-0.06727351,0.056402113,-0.15791291,0.03650701,-0.012222368,0.023587262,0.06291487,0.02737856,-0.016865779,-0.0042007547,0.015821101,-0.017258387,-0.025061365,0.018067062,-0.068989664,-0.034303714,-0.00062582176,0.021533197,-0.04163426,-0.025685126,0.092920855,0.057867263,-0.026653664,-0.0078943465,0.02459152,0.02201057,0.007453262,6.906498e-05,-0.024613947,0.042787913,0.05228116,-0.1166373,0.002261372,-0.04156403,-0.048562314,-0.032235835,0.05561256,-0.03586449,-0.077665895,-0.017039048,0.023207054,-0.05525264,0.1481202,-0.053710435 +3.1.11.2,Preference for double-stranded DNA. Has endonucleolytic activity near apurinic sites on DNA.,384,1.0,-0.055512793,-0.040734306,-0.05128211,-0.019574944,-0.056172863,-0.02343057,-0.04153849,0.07776836,-0.012567305,0.04471237,0.07113272,0.054884817,-0.058085393,0.0646595,-0.035486244,0.091490686,-0.050563224,0.019816717,0.088003345,-0.05322522,0.07143837,0.041044466,0.08313422,-0.037001014,-0.05386666,-0.0050064917,-0.037192818,0.029609049,-0.00052452844,-0.0869092,0.03240375,-0.057452068,-0.053089906,0.024893269,0.08341833,0.084138274,-0.0037086785,0.08626764,-0.008556729,-0.066716015,0.0929853,0.013356559,-0.028170878,0.08281539,-0.044534896,-0.021644983,0.0021697371,-0.059310522,0.0027675224,0.046080526,0.08956702,0.00691412,0.01350624,-0.01622331,0.006522954,0.068939544,-0.07768207,0.0017209221,-0.005817672,0.043735154,0.03244653,0.014804878,-0.06627461,-0.015239816,0.105942115,-0.071996324,0.082828745,-0.03970694,-0.10095234,-0.023198524,0.052726008,-0.057150885,-0.03665033,-0.005209456,0.0073838546,0.08886579,-0.034600627,-0.061684974,-0.019769572,0.026808413,-0.027061101,-0.12459339,0.012331478,0.028305933,-0.05160685,0.005085863,0.07064896,-0.011413054,0.015841272,0.09739715,-0.019311696,-0.06292761,0.029090138,-0.010112516,-0.044998202,0.043484982,0.016450638,0.03573188,-0.024176704,-0.09750305,-0.016090503,-0.071275435,-0.024825815,-0.019236894,0.0035790661,-0.062342282,0.002842374,-0.017835015,0.11521389,-0.043212943,-0.00966664,0.08314162,0.014772702,0.0047681,-0.034485888,-0.0019521393,-0.0072643803,0.001415039,0.018478919,0.00741,0.0042427015,-0.025912775,0.027178237,0.04401645,-0.018862002,-0.1181387,0.044671025,-8.118157e-34,-0.031403847,0.041506544,0.06690673,0.03059626,-0.028787484,0.035414662,-0.06548632,0.023800755,-0.07420219,-0.03237582,-0.026287934,-0.009204325,0.06888196,0.11206716,-0.02631395,0.0032192278,0.017681632,-0.037008546,0.013676559,-0.033303224,0.024139496,0.01648147,0.036142267,0.029361969,0.05871459,-0.029281775,-0.06204214,0.037973125,0.081477396,0.0011228293,-0.04605583,-0.05660885,0.026341831,0.12682205,0.08826256,0.092302,0.027287448,-0.05364076,0.024756974,0.04120572,-0.05809681,-0.026682837,-0.0040394375,-0.025388699,0.089234024,-0.084909484,-0.021691164,-0.024504988,-0.094283916,-0.017063534,-0.021998176,-0.011090376,0.05583243,0.031090273,-0.0035680968,-0.0038503928,-0.008868065,-0.022194885,0.019796008,0.0483727,0.027408414,0.085527435,-0.024605753,-0.08738305,-0.006797537,-0.0511228,-0.008719971,-0.039884657,0.017733056,0.0951935,0.044056524,-0.06345254,0.035407435,0.020120319,-0.014280204,0.04259167,-0.040133968,0.056502495,0.07003692,-0.006840392,0.0065988726,-0.018648978,-0.025262574,-0.014478754,-0.05264438,0.00070056703,-0.037526637,-0.081577905,0.0093209315,0.07645281,0.08641798,0.014159121,-0.009694702,0.018980568,0.014274079,-1.5791086e-33,0.10737214,-0.12147829,0.04218625,-0.008984303,-0.059599474,-0.0015606919,0.042248674,-0.020940794,0.035861064,-0.013002214,0.011783491,-0.051470604,-0.010525261,-0.04412133,-0.001800217,0.030552778,0.062109854,0.08056011,0.05022425,0.00934316,-0.052910935,0.09671816,-0.026939841,0.019242767,0.06383226,-0.017120564,-0.07230468,-0.03779477,-0.042400595,-0.048756946,-0.089754105,-0.015311388,0.08195546,-0.055963676,-0.016566698,0.082299806,-0.0020128195,-0.016898774,0.017366184,-0.048021358,-0.044423524,0.055923276,-0.031782433,0.0584261,0.04937281,0.051848017,-0.04370916,0.039126765,-0.046780687,-0.033413555,0.045351926,-0.0011072507,-0.05321682,-0.023644209,0.022942761,-0.073742375,0.00801462,-0.052940503,0.029419698,-0.041888688,0.027440133,-0.062325086,-0.003635131,-0.015476888,0.015790472,0.0032277936,0.0103821475,0.07322961,0.0017652281,-0.05932876,-0.018830845,-0.025852185,0.022200149,0.024583695,-0.050109107,0.07065606,-0.057690747,-0.09740048,0.070355654,-0.05393804,-0.087001055,0.012702147,-0.056693397,-0.015606857,0.101998694,-0.023347748,-0.008406567,0.013608312,-0.06508195,-0.054613266,-0.009908801,-0.009195478,-0.03354365,0.038404036,0.012428086,-2.5248163e-08,0.05212763,-0.06118231,0.019954436,-0.10085821,0.009421087,-0.01918321,0.004479848,0.07047374,0.12526613,-0.046356585,-0.047290426,0.037387718,0.029151147,0.02159129,0.07229517,0.027229693,-0.014831294,-0.012601455,-0.021684103,0.03533562,-0.118160844,0.049222227,-0.16956618,-0.0021334183,-0.0437735,0.056572508,0.055129416,0.00023089885,-0.03942199,-0.076563284,0.08509816,-0.08030295,-0.024098668,-0.01604007,0.0028817463,0.09122523,0.06867035,0.011925422,-0.021637442,0.07402757,0.034410413,-0.0026943819,0.049111083,0.041080877,-0.04889017,-0.013469177,0.05144166,0.044813853,-0.075726666,-0.01812665,0.055497583,-0.07780341,-0.010715193,-0.119469404,-0.053681668,-0.06185737,0.024561968,-0.031187205,-0.040192958,0.010760261,0.058936678,-0.0059984457,0.0931908,-0.025712576 +3.1.11.3,Preference for double-stranded DNA. Does not attack single-strand breaks.,384,0.99999994,-0.074494906,-0.0130397845,0.04603467,-0.027711384,-0.011598767,-0.023293069,-0.07693829,0.11297797,-0.03167612,0.045967627,0.070801854,0.10532236,-0.1017515,0.0053582047,0.024267882,0.08054481,-0.06012162,-0.01494515,0.040803988,-0.0016938833,0.034778126,-0.013819704,0.084844,0.0060442146,-0.024969826,-0.009847996,-0.045134477,0.09181987,0.017953947,-0.10566846,0.03400598,0.022891711,-0.03215723,0.004517043,-0.006976514,-0.006889961,0.039692994,0.042200353,-0.026690528,-0.016503165,0.04555701,0.00991251,0.010589957,0.07032358,-0.055622477,-0.061899696,-0.011080253,-0.0047332183,0.040366895,0.06680119,0.007816906,0.017755516,-0.024280585,0.06745129,0.049868476,0.062341332,-0.14703302,-0.006061507,-0.015323445,0.04555643,0.018804837,0.03851012,-0.042535234,0.0001612633,0.17592898,-0.014717554,0.08476035,-0.025271092,-0.055140678,0.005180143,0.028443007,-0.065990314,-0.04906024,0.06430489,-0.0024828683,-0.0103785675,-0.040183835,-0.07490785,0.030234987,0.0856035,-0.10803709,-0.04543948,0.02818528,-0.0092734555,0.05717233,0.02142036,0.029166799,0.032014683,-0.044590365,0.033925,0.013355647,-0.0010621594,0.12053378,0.0005309041,-0.0375668,0.071853966,-0.06987038,0.062974334,-0.028438361,-0.06325788,0.060845055,-0.06628938,-0.02053668,0.019386915,-0.0234631,-0.12577541,0.006874049,-0.064591944,0.051684845,-0.037726566,0.051776916,0.055074956,-0.030527368,-0.0154747935,-0.10123911,-0.04924928,-0.043738823,0.047710042,0.028410515,0.042458776,-0.018388817,-0.10115545,0.016269708,0.020239161,-0.07472066,-0.06515519,0.0031793476,-2.9833455e-33,-0.02791153,0.054469302,0.061448533,-0.010311515,-0.028150322,0.0017268226,-0.08643964,0.011195932,-0.08289713,0.030647947,-0.058105562,-0.052775133,0.07237161,0.055234272,0.032408718,0.07538398,-0.011704996,-0.0046468643,-0.03591949,0.009522804,0.00043470526,0.008609672,0.05924785,0.0033226183,0.05697923,-0.08171033,0.0035854382,0.019194113,0.052393787,0.028853191,-0.048274986,-0.06724256,-0.0056183506,0.0896941,0.051920544,0.065133445,-0.070947886,-0.06465946,-0.019074833,0.07570871,-0.116143875,0.012452597,0.035216644,-0.05122052,0.08600559,-0.06936006,-0.058524676,-0.006832012,-0.1247807,-0.0042927954,-0.01383657,0.004822795,0.0019974841,0.050952964,0.016259598,0.01822558,0.046653938,-0.0054745916,-0.030816121,0.11049578,-0.06514759,0.029281048,-0.0019772328,-0.056557357,-0.038733337,0.0445801,-9.661143e-05,-0.046149977,-0.014068675,0.02208149,0.0024031298,-0.052639827,0.02741419,-0.027867755,-0.041947275,0.018137127,-0.024306467,0.06127668,0.0866698,0.032211516,-0.041602492,-0.05703353,-0.014740833,-0.0068178456,-0.05791563,0.02774412,-0.023194335,-0.09991903,0.014905021,0.04552918,0.15711294,-0.037728995,-0.0012258245,-0.062836245,0.029500423,6.9927206e-34,0.0494677,-0.10295817,0.0324828,0.02999584,0.004497627,-0.025606766,-0.0015970523,-0.021455,0.026830906,-0.05799623,0.07636256,0.0042708376,-0.09158501,0.010445604,0.052468188,-0.010162162,0.010118885,-0.00084081653,0.05130882,-0.028197497,0.008452303,0.07739108,-0.048229177,0.10671563,0.057941455,-0.008208573,-0.053482477,-0.017895192,0.04679214,-0.016650876,-0.11379275,0.00969501,0.05030544,0.0028499218,-0.02177968,0.07784981,0.02050539,0.03102653,0.023747277,0.017554572,-0.001686848,0.096991055,-0.036848005,0.09116321,-0.016943978,0.01276096,-0.022727884,0.038308416,0.02973342,0.01681541,0.061946247,0.0060309796,-0.004320261,-0.05542406,0.028244505,-0.0757604,-0.003963162,-0.027057292,-0.062573366,0.030085893,-0.05348214,-0.023242742,-0.008813702,0.022050679,0.016277617,-0.030368153,-0.0154618,0.03532604,-0.0021955997,-0.07930271,0.050924208,0.010468155,0.056636054,-0.029833721,-0.05531115,0.023068829,-0.12298465,-0.07563871,-0.012880961,0.03591136,-0.066301554,-0.031782765,-0.094061404,0.044043835,0.08428866,-0.027545938,0.008890258,0.02045696,-0.04206683,-0.09285299,0.007447564,0.034916874,-0.04224743,0.07218142,-0.03843508,-2.0366606e-08,0.07212093,-0.003959574,0.014085651,-0.045775324,0.041942924,0.05226519,-0.049593337,0.017886585,0.06364675,0.022017498,0.016798902,0.12334877,-0.037061196,0.060766917,0.04813155,-0.04147243,-0.041695785,-0.02130864,-0.06948331,0.06854977,-0.06952318,0.040726583,-0.09518804,0.035955705,-0.06071935,0.024084516,0.052478142,0.034776535,0.013290504,-0.06699956,0.012897953,-0.048778743,-0.010656526,0.081435174,-0.05461821,0.044699237,0.048582815,0.024187213,0.016215753,-0.010170597,0.033350345,-0.019356579,0.024139274,0.022157116,-0.04131669,-0.03170517,0.049414404,0.004077929,-0.078752294,0.048982784,0.005519558,-0.02848098,0.030028602,-0.036644746,-0.018258085,0.008673386,0.018942393,-0.0022097654,-0.0076687005,0.013339285,0.06926236,-0.07013583,0.087532535,-0.0037550342 +3.1.11.4,Preference for single-stranded DNA.,384,1.0,-0.06887164,0.026150934,-0.017373675,-0.0063434355,-0.019519318,-0.0053421464,-0.024953408,0.106621884,-0.007336376,-0.010197531,0.08124771,0.08132842,-0.09287681,0.005366328,-0.0022151398,0.03139686,-0.06035213,-0.04536524,0.056482323,-0.006643314,-0.025409633,-0.025650792,0.08249768,-0.016126456,-0.014534207,-0.00058024074,-0.04102859,0.049318686,-0.0050270474,-0.10464189,0.024601318,0.035552144,-0.029417422,-0.037958357,0.012374752,-0.012090477,0.037090003,0.024391929,-0.038580053,0.008488913,0.08350781,0.03053912,-0.013959307,0.09981193,-0.06194064,-0.06419853,0.022050152,0.013041124,0.03455076,0.051267397,0.067245565,0.007656625,-0.016703371,0.009300927,0.018502982,0.050463732,-0.14721516,-0.03337049,-0.021593511,0.00769105,0.009906179,0.023476437,0.007774064,-0.039204724,0.18254036,-0.04458404,0.11416064,-0.042810414,-0.031362507,0.018759228,0.019149069,-0.0235789,-0.023159655,0.06332262,-0.02197228,-0.021231662,0.00046998047,-0.07469168,0.010522426,0.12381261,-0.08943686,-0.06053677,-0.023039471,-0.0016592363,0.014069214,0.003978979,0.03190381,0.041103147,-0.04088901,0.03464441,0.011598312,0.006815468,0.08872908,-0.04039133,-0.09259691,0.07948779,-0.029376116,0.06415563,-0.00019387889,-0.061948653,0.058490407,-0.08158265,-0.008329995,0.09105944,-0.0312188,-0.06392155,0.0037146914,-0.054669548,0.05948405,-0.021942487,-0.036897767,0.0219972,-0.025116771,0.043562073,-0.12679303,-0.073638104,-0.076674156,0.028229995,0.04164227,0.048440896,-0.06442723,-0.081576906,0.058917113,0.032843262,-0.020583553,-0.04149941,-0.0063760555,-5.6344093e-33,-0.04894409,0.08037753,0.034854352,0.017156942,-0.0506938,0.008645534,-0.038975615,0.04382713,-0.09908503,-0.002874843,-0.060311627,-0.010881998,0.051777612,0.034804966,0.0041097933,0.0904599,-0.01647825,-0.009668126,-0.022415776,-0.017051522,0.0062894532,0.061260354,0.023155466,0.0071986034,0.048357777,-0.11098538,0.02087836,0.01996071,0.04433876,-0.014371132,-0.037314504,-0.018203711,0.021775177,0.041477226,0.06842537,0.06411854,-0.031856414,-0.033553764,0.015714632,0.06024125,-0.06465251,0.033353675,0.08158283,-0.06407342,0.105954595,-0.005303013,-0.016451929,-0.044085946,-0.15189403,-0.025355767,-0.038622987,0.023856694,0.008192784,0.039171223,0.008351828,-0.037470754,0.020029588,-0.020886596,-0.056671277,0.031124054,-0.07442825,0.017667502,-0.019811584,-0.06823981,0.023125088,0.077186614,0.0011782643,-0.05285371,-0.006493515,-0.031748313,0.05921198,-0.07317639,-0.030340867,-0.071058005,-0.06444071,0.026044466,0.0069978037,0.024903847,0.038526144,-0.0059124553,-0.033419464,0.015976034,-0.07286814,0.021501662,-0.005136589,0.0083155045,0.011708721,-0.05227456,0.0702724,0.06331467,0.10859035,-0.036991674,-0.004197079,-0.12470522,0.030265715,3.1705665e-33,0.05546811,-0.10335777,0.044416625,0.042844456,-0.007292354,0.013365804,0.06748977,-0.03237741,0.016312357,-0.02273539,0.06525441,0.009389618,-0.065003954,-0.019855926,-0.0043660747,0.08497325,-0.038195074,0.006212331,0.042455003,-0.0048365737,-0.02320594,0.04073278,-0.050845247,0.075235836,0.020403137,-0.0071486966,-0.061980594,0.0018468584,0.0064669647,-0.061803404,-0.11572406,0.010395542,0.04542145,-0.075041935,0.014408163,0.054068282,0.010280776,0.07432761,0.060035508,0.053132143,-0.060726166,0.09520953,-0.016204271,0.07423272,0.026510628,0.0497829,-0.03512577,-0.007936567,0.035906523,0.045731097,0.06835908,0.03657402,-0.048532613,-0.11631862,0.00041332925,-0.060527425,0.020891018,0.006259253,-0.021425609,0.039519094,-0.016029617,-0.030440358,-0.014293686,-0.013512087,-0.02599875,-0.00039773827,0.07521614,0.028014844,-0.037875935,-0.06065477,0.019477986,-0.05164353,0.09394577,-0.008118767,0.007153024,0.020058146,-0.075617775,-0.03751416,0.016007392,0.016112229,-0.10421115,-0.013698797,-0.08302144,0.011501923,0.11346036,0.022228226,0.05183091,-0.023241716,-0.019388124,-0.026906317,0.029106576,0.005781133,0.011206355,0.0051361257,-0.046544258,-1.4895557e-08,0.08139857,-0.026852567,0.017637666,-0.05447699,0.0211948,0.07051577,-0.051590666,-0.0022413896,0.06835424,0.0545706,0.026778637,0.091783546,-0.06805245,0.100721605,0.10291378,0.02205527,-0.06828882,-0.070659,-0.04815273,0.09130725,-0.04678509,0.06735291,-0.13221543,-0.004133759,-0.03252255,0.011945292,0.08149076,0.019420218,0.020877173,-0.04248715,0.029046735,-0.040901136,-0.012261394,0.07165229,-0.009824501,-0.021478355,0.033516172,0.05709661,-0.018127687,-0.010866819,0.08531163,0.018309167,-0.018317822,0.0018789913,-0.009511097,-0.036006954,0.06250383,-0.00463842,-0.06687623,0.06907282,-0.01770992,-0.05811309,0.008112929,-0.049026866,0.02713976,0.0044589415,0.050047357,0.013715161,-0.049164772,0.019737532,0.05668201,-0.04574321,0.040628083,-0.05177483 +3.1.11.5,Preference for double-stranded DNA. Possesses DNA-dependent ATPase activity. Acts endonucleolytically on single-stranded circular DNA. 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+3.1.11.6,Preference for single-stranded DNA.,384,1.0,-0.06887164,0.026150934,-0.017373675,-0.0063434355,-0.019519318,-0.0053421464,-0.024953408,0.106621884,-0.007336376,-0.010197531,0.08124771,0.08132842,-0.09287681,0.005366328,-0.0022151398,0.03139686,-0.06035213,-0.04536524,0.056482323,-0.006643314,-0.025409633,-0.025650792,0.08249768,-0.016126456,-0.014534207,-0.00058024074,-0.04102859,0.049318686,-0.0050270474,-0.10464189,0.024601318,0.035552144,-0.029417422,-0.037958357,0.012374752,-0.012090477,0.037090003,0.024391929,-0.038580053,0.008488913,0.08350781,0.03053912,-0.013959307,0.09981193,-0.06194064,-0.06419853,0.022050152,0.013041124,0.03455076,0.051267397,0.067245565,0.007656625,-0.016703371,0.009300927,0.018502982,0.050463732,-0.14721516,-0.03337049,-0.021593511,0.00769105,0.009906179,0.023476437,0.007774064,-0.039204724,0.18254036,-0.04458404,0.11416064,-0.042810414,-0.031362507,0.018759228,0.019149069,-0.0235789,-0.023159655,0.06332262,-0.02197228,-0.021231662,0.00046998047,-0.07469168,0.010522426,0.12381261,-0.08943686,-0.06053677,-0.023039471,-0.0016592363,0.014069214,0.003978979,0.03190381,0.041103147,-0.04088901,0.03464441,0.011598312,0.006815468,0.08872908,-0.04039133,-0.09259691,0.07948779,-0.029376116,0.06415563,-0.00019387889,-0.061948653,0.058490407,-0.08158265,-0.008329995,0.09105944,-0.0312188,-0.06392155,0.0037146914,-0.054669548,0.05948405,-0.021942487,-0.036897767,0.0219972,-0.025116771,0.043562073,-0.12679303,-0.073638104,-0.076674156,0.028229995,0.04164227,0.048440896,-0.06442723,-0.081576906,0.058917113,0.032843262,-0.020583553,-0.04149941,-0.0063760555,-5.6344093e-33,-0.04894409,0.08037753,0.034854352,0.017156942,-0.0506938,0.008645534,-0.038975615,0.04382713,-0.09908503,-0.002874843,-0.060311627,-0.010881998,0.051777612,0.034804966,0.0041097933,0.0904599,-0.01647825,-0.009668126,-0.022415776,-0.017051522,0.0062894532,0.061260354,0.023155466,0.0071986034,0.048357777,-0.11098538,0.02087836,0.01996071,0.04433876,-0.014371132,-0.037314504,-0.018203711,0.021775177,0.041477226,0.06842537,0.06411854,-0.031856414,-0.033553764,0.015714632,0.06024125,-0.06465251,0.033353675,0.08158283,-0.06407342,0.105954595,-0.005303013,-0.016451929,-0.044085946,-0.15189403,-0.025355767,-0.038622987,0.023856694,0.008192784,0.039171223,0.008351828,-0.037470754,0.020029588,-0.020886596,-0.056671277,0.031124054,-0.07442825,0.017667502,-0.019811584,-0.06823981,0.023125088,0.077186614,0.0011782643,-0.05285371,-0.006493515,-0.031748313,0.05921198,-0.07317639,-0.030340867,-0.071058005,-0.06444071,0.026044466,0.0069978037,0.024903847,0.038526144,-0.0059124553,-0.033419464,0.015976034,-0.07286814,0.021501662,-0.005136589,0.0083155045,0.011708721,-0.05227456,0.0702724,0.06331467,0.10859035,-0.036991674,-0.004197079,-0.12470522,0.030265715,3.1705665e-33,0.05546811,-0.10335777,0.044416625,0.042844456,-0.007292354,0.013365804,0.06748977,-0.03237741,0.016312357,-0.02273539,0.06525441,0.009389618,-0.065003954,-0.019855926,-0.0043660747,0.08497325,-0.038195074,0.006212331,0.042455003,-0.0048365737,-0.02320594,0.04073278,-0.050845247,0.075235836,0.020403137,-0.0071486966,-0.061980594,0.0018468584,0.0064669647,-0.061803404,-0.11572406,0.010395542,0.04542145,-0.075041935,0.014408163,0.054068282,0.010280776,0.07432761,0.060035508,0.053132143,-0.060726166,0.09520953,-0.016204271,0.07423272,0.026510628,0.0497829,-0.03512577,-0.007936567,0.035906523,0.045731097,0.06835908,0.03657402,-0.048532613,-0.11631862,0.00041332925,-0.060527425,0.020891018,0.006259253,-0.021425609,0.039519094,-0.016029617,-0.030440358,-0.014293686,-0.013512087,-0.02599875,-0.00039773827,0.07521614,0.028014844,-0.037875935,-0.06065477,0.019477986,-0.05164353,0.09394577,-0.008118767,0.007153024,0.020058146,-0.075617775,-0.03751416,0.016007392,0.016112229,-0.10421115,-0.013698797,-0.08302144,0.011501923,0.11346036,0.022228226,0.05183091,-0.023241716,-0.019388124,-0.026906317,0.029106576,0.005781133,0.011206355,0.0051361257,-0.046544258,-1.4895557e-08,0.08139857,-0.026852567,0.017637666,-0.05447699,0.0211948,0.07051577,-0.051590666,-0.0022413896,0.06835424,0.0545706,0.026778637,0.091783546,-0.06805245,0.100721605,0.10291378,0.02205527,-0.06828882,-0.070659,-0.04815273,0.09130725,-0.04678509,0.06735291,-0.13221543,-0.004133759,-0.03252255,0.011945292,0.08149076,0.019420218,0.020877173,-0.04248715,0.029046735,-0.040901136,-0.012261394,0.07165229,-0.009824501,-0.021478355,0.033516172,0.05709661,-0.018127687,-0.010866819,0.08531163,0.018309167,-0.018317822,0.0018789913,-0.009511097,-0.036006954,0.06250383,-0.00463842,-0.06687623,0.06907282,-0.01770992,-0.05811309,0.008112929,-0.049026866,0.02713976,0.0044589415,0.050047357,0.013715161,-0.049164772,0.019737532,0.05668201,-0.04574321,0.040628083,-0.05177483 +3.1.13.1,"Preference for single-stranded RNA. The enzyme processes 3'-terminal extra-nucleotides of monomeric tRNA precursors, following the action of EC 3.1.26.5 ribonuclease P.",384,0.99999994,0.004960626,-0.10938908,-0.053310256,-0.062270705,0.009231873,-0.0015387348,-0.07847516,0.012736948,0.02636817,0.041325845,0.043841016,-0.0030369752,-0.0906801,0.018395161,0.0054047992,0.00049601606,-0.16705763,-0.06481797,0.019996973,-0.03306333,0.012445407,0.07307989,0.0026646908,0.010998547,0.00798878,-0.047436934,0.061401352,-0.039584413,0.010927752,-0.03706746,-0.049082465,-0.062038813,0.11797505,-0.005680731,0.01699368,0.033899676,-0.09973887,-0.031258054,0.043715548,0.106559224,0.065931104,0.01834391,0.015121123,-0.036529753,-0.058308143,-0.0732413,0.0016595258,0.027957406,0.03006581,0.0545049,0.10907395,-0.023885073,-0.05848875,-0.027599031,0.016266853,0.067703374,-0.06010775,-0.020529961,-0.039323546,-0.0023374865,0.0070195766,-0.0003243534,-0.012544664,-0.0719225,0.13674796,-0.04609184,0.07671999,0.006518793,0.0071496246,0.025384441,-0.025512509,-0.024369586,-0.073447004,0.065526776,-0.020314883,-0.0071618576,0.051496744,-0.018491674,-0.02972376,0.042697772,-0.049504515,-0.05471772,-0.031794965,-0.01906403,-0.013287921,0.05514131,-0.009329582,0.05087241,-0.032182623,0.066778205,0.044164732,-0.018296363,0.036482994,0.012337198,-0.023607315,0.10401731,0.009085765,0.07829054,0.040535856,-0.1137728,0.055518385,0.07676116,0.013127866,0.048638802,0.019505315,0.014110376,0.04530035,0.0002972161,-0.039519683,0.041433237,0.02455217,-0.03355243,0.040296026,-0.03138212,-0.023684623,0.058413964,0.0011740403,-0.024371494,0.060139842,0.054273687,-0.02481309,-0.0030639805,0.077461645,0.056211952,-0.062335532,0.01130818,-0.039189365,-1.1911108e-33,-0.0033097,-0.004517069,0.008550744,0.018736783,-0.019635908,0.034337066,-0.084638834,0.018400036,-0.102532126,-0.008741423,-0.08922943,-0.054924153,0.047193397,-0.044364598,-0.018578142,-0.018371845,-0.029314417,0.022755232,-0.073158726,0.020247607,0.025293594,0.0491989,0.010017938,0.057764694,0.037571657,-0.040208507,0.015266709,0.004407402,0.08611887,-0.03156446,-0.032227844,-0.0036246765,-0.0592365,0.02844293,0.053477462,-0.01954355,-0.010444758,0.0014128591,-0.00792761,0.06529895,-0.0072407527,0.0069633015,0.03761945,-0.064700544,0.04961299,0.0062021576,-0.007328564,0.019730719,-0.04769659,-0.01167101,0.033685308,0.009529923,0.05871963,-0.013576522,0.025784673,-0.053549204,-0.022316486,-0.022328505,0.0835105,0.02550676,-0.023349948,0.037256833,-0.008174131,0.104888864,-0.05530908,0.031750757,-0.048256896,-0.07163039,0.010827664,0.058745682,-0.02693135,-0.06916477,0.034431346,-0.060515765,-6.1293704e-06,0.009404831,-0.03623471,-0.032523975,-0.015886256,0.033074383,-0.061251067,0.00064863556,-0.012997067,0.011464186,0.011027672,-0.021611964,0.046995346,-0.08530047,0.028958632,0.09132482,0.046090994,0.012946911,-0.108602464,-0.0067876205,0.03896174,-2.5287055e-34,0.067479834,-0.09167991,-0.007041748,-0.035493955,-0.11418771,0.06915905,-0.017311435,-0.11772848,0.008394858,-0.06656802,0.072400294,0.057066057,-0.06442678,-0.057273343,0.030870559,-0.017986922,-0.006836523,0.0521451,-0.025846679,0.00922624,0.07482937,0.009904518,-0.074802235,0.024082864,0.02474455,-0.04565376,-0.0024274609,0.07528023,-0.007146395,-0.0056201834,-0.0872955,0.019249843,0.09050036,0.076763175,-0.06542016,0.02044911,0.018881233,0.03631425,0.09043202,0.01895066,-0.06351784,0.05462991,-0.019314263,0.07913483,-0.010405455,0.052741703,-0.03916343,-0.043714665,-0.011177941,-0.03071108,0.09808089,-0.019620989,0.035959605,0.003934665,0.05421941,-0.038980734,-0.05454729,0.042657897,0.049304068,0.0040814956,-0.038177073,-0.042996366,0.000976485,-0.064134575,0.025827128,-0.032520965,-0.01601919,0.056896787,0.027973428,-0.046427585,-0.02359674,0.012750975,0.015399534,-0.02420482,0.04324349,-0.050520647,-0.11092066,-0.023643687,0.007665631,-0.05471922,-0.09100874,-0.0009259405,-0.0107917,-0.027928842,0.07152297,-0.076061375,0.07530196,0.12737921,-0.047856078,0.0574924,-0.0039935536,0.013251104,0.0016364666,0.013247119,-0.014498679,-3.039822e-08,0.0003078256,0.020524297,-0.008259561,0.016156605,0.08997429,0.0763126,-0.019486975,0.048952222,0.061523765,0.03522263,-0.015814966,-0.017840855,-0.01885983,0.031131988,0.14450166,0.012606608,-0.15023388,-0.032712184,-0.016475966,0.024615416,-0.063011944,0.12679772,-0.1662404,0.004575586,-0.06951801,0.04304044,0.009038456,0.07590164,-0.0007982001,-0.043873604,0.05625514,-0.018694058,0.032335933,-0.034902636,-0.10318318,0.02982535,0.07979874,0.004970527,-0.03644629,0.040084705,0.004755441,-0.020608004,-0.05406687,-0.024786822,-0.11346928,-0.025652312,-0.046411455,0.083708815,-0.05037803,0.014682414,0.044745944,0.026812557,0.045385875,-6.5556173e-07,0.02708238,0.025648624,-0.012078984,-0.0759329,-0.06311744,0.06375145,0.045426153,-0.06500401,0.10867242,-0.014420719 +3.1.13.2,This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13 (retroviral ribonuclease H).,384,0.99999994,-0.010467057,0.01590347,-0.023014357,-0.04839038,0.025025927,0.041293386,-0.074076034,-0.016991114,0.03986252,0.066250525,0.038869433,0.009308764,-0.09760851,-0.018703563,-0.04376903,0.048672933,-0.13369443,0.030333703,-0.028664142,0.0056318883,-0.01540089,0.08845194,0.029474173,-0.038610384,-0.01289444,0.032813583,0.03535337,0.002661143,-0.029471558,-0.050715193,0.06970244,-0.082895085,0.060940553,-0.016006973,-0.023321474,0.0465594,-0.04697576,-0.10504619,0.0032857968,0.05373144,0.03424449,0.0032710754,-0.0018622249,-0.031656496,0.030917339,-0.026186263,-0.045939386,0.045132548,0.031229634,0.054742772,0.06723947,-0.06540981,-0.047690585,-0.025904173,0.05087942,0.08767472,-0.057878684,-0.03261694,0.040755633,0.0073917652,0.034885295,-0.0075764023,-0.06769511,-0.062089358,0.041122373,-0.09362004,0.07057663,-0.009974043,-0.01565489,0.021688683,-0.02099695,-0.076909244,-0.10382857,0.023729082,-0.01803922,0.033673428,0.03847939,-0.07157557,0.06924469,0.02017179,-0.07913603,-0.05628948,0.023097895,0.037221983,-0.06553047,0.013278774,-0.0027497944,0.033119522,-0.019778822,0.08101267,-0.0244927,-0.08651657,0.031090142,0.0040598977,-0.0075240466,0.05868492,0.029274913,0.012746267,0.047177013,-0.04926423,0.02527394,0.07061028,-0.050081976,-0.097879834,0.006229844,0.041849025,0.007405108,0.084991835,-0.021336354,-0.04052956,-0.0053072465,-0.04700802,-0.015873963,-0.07850418,0.04462586,0.10357061,0.015200773,-0.0009266232,0.04501926,0.012629894,0.07756665,-0.02063627,0.0010653766,0.088830754,-0.0937746,-0.06991617,-0.042678297,-9.677638e-35,0.015690798,-0.030568542,-0.005979242,0.05338759,-0.022232333,0.049802072,-0.07167888,0.00756367,-0.081737205,-0.07599642,-0.09652879,-0.11352903,0.044868663,-0.034317426,-0.075632334,-0.038344257,-0.0066752634,0.019320574,-0.08558588,-0.0023079964,0.049005892,0.06852697,0.023294322,-0.01963717,0.023777202,-0.035839744,-0.036429603,0.010631954,0.07309798,-0.03138972,-0.022987667,0.00872246,-0.03439731,0.05470277,-0.0037851308,0.021556435,0.053566698,-0.03810774,0.102163374,0.07721459,0.08674888,-0.016420372,-0.03794715,0.00017116446,0.11199783,0.006391946,0.039458938,0.058363087,0.022331525,0.010387298,0.07548251,-0.03527002,0.048743524,-0.023634832,-0.00015138237,0.006940932,-0.047719054,0.03049621,0.03384481,0.06743547,-0.015232986,0.028109632,0.013775392,0.12941243,-0.035175715,-0.021787766,-0.025142947,-0.064073846,-0.0047282516,0.054184247,-0.029985422,0.010312311,0.09056436,-0.0029298952,0.0028231877,0.034595717,-0.078590274,-0.028802343,0.044645544,0.07451077,-0.08544935,0.04184849,-0.008846191,-0.019114101,0.0108861495,0.009701346,-0.03549927,-0.13367563,0.002813269,0.10006436,0.053152073,-0.08575287,-0.07155605,0.030734703,0.047677286,-1.6987747e-33,0.05015726,-0.07196494,-0.005111688,-0.039425626,-0.12884797,0.031895112,0.042994186,-0.06041734,-0.013201598,-0.011294627,0.04415923,-0.026673758,0.04089388,-0.06859751,0.011156694,-0.026758518,0.047648024,0.046896823,-0.04770734,0.027268667,0.038678724,-0.0049524927,-0.038093697,-0.033628713,0.054468717,-0.008052237,0.042681642,0.008387232,0.033680107,0.0046144947,-0.041534238,-0.042900264,0.06952749,0.03826618,0.024774684,0.09221249,0.009855899,-0.01399956,0.018797021,-0.074525006,-0.022670705,0.019935098,-0.041814458,0.06457251,-0.017837863,0.049716122,-0.013856417,0.029689848,-0.007639936,-0.059784606,0.02906492,-0.06451867,0.035031963,0.07352425,-0.038626198,-0.054510213,0.00027818402,0.056024015,0.118811384,-0.0033061889,-0.0052946643,-0.01571149,0.031515002,-0.09746973,0.07707069,0.041559495,-0.029672053,0.074552424,0.023518197,-0.09648702,0.046165098,-0.00487815,-0.0025017415,-0.040994376,0.0032051224,-0.05011302,-0.039356727,-0.047450393,-0.008347734,-0.03328954,-0.090723105,0.0038450018,-0.008007558,-0.005900851,0.050420832,-0.070278004,0.054947447,0.112425715,-0.066099234,0.086981334,-0.010184664,-0.016932558,0.0038133473,0.048449725,0.004359627,-2.9667433e-08,0.0018532347,-0.012354576,0.02149065,-0.049786385,0.08310293,0.09635982,-0.008061005,0.08001023,0.058976155,-0.0025532667,0.034468815,-0.008506937,0.05916329,-0.04792075,0.06573413,0.0020304862,-0.067803234,-0.016248154,0.011063113,-0.04365116,-0.08460666,0.056612995,-0.07242748,-0.023123272,-0.08695472,-0.00023648473,0.0036663616,0.08394495,0.023744004,-0.13210475,0.03440993,0.0030780875,0.017509397,-0.03671496,-0.08929815,0.08857967,0.112650186,-0.0072723823,0.013414941,0.02244179,-0.028794011,-0.04950488,-0.02863943,0.020718083,-0.09577651,-0.043466046,-0.032730583,0.07991943,-0.03300044,-0.040882524,0.056944285,-0.021901833,0.024513619,-0.03920108,-0.054699473,-0.0176476,-0.02737241,-0.061280403,-0.015903983,0.0688206,0.012926864,-0.033210717,0.10049331,0.022571966 +3.1.13.3,Also hydrolyses NAD+ to NMN and AMP.,384,0.99999994,-0.06704004,-0.036323108,-0.051876053,-0.010182063,-0.06834348,0.014384406,-0.031555183,0.03379875,-0.010172344,-0.020069215,-0.0064623184,0.0037576156,-0.019883849,0.042908266,-0.047226027,0.02809523,-0.004154777,0.07607481,0.0110430755,-7.711186e-05,0.09212302,0.025459323,0.03847054,-0.027394747,0.03061564,0.06915589,0.0014370139,0.027623344,0.029469324,-0.113225535,0.018023904,0.022878407,-0.037641592,-0.089271955,-0.049694717,0.07387678,-0.073333345,0.017302737,-0.01736344,0.043077216,0.05661291,-0.037423387,0.064807735,-0.016326508,-0.025701698,-0.10098626,0.027528878,0.02544102,0.076330945,-0.000283922,0.00765436,-0.09447493,-0.008898482,0.028519355,0.030281246,0.026730383,-0.1028324,0.052452963,-0.016720694,-0.02287283,0.000258576,0.03925458,-0.078623034,0.027575687,0.10676382,-0.04802368,0.04949705,0.010375296,0.01089576,-0.0065143243,-0.06618317,-0.019974276,0.009734252,-0.016328562,-0.024083734,0.084543705,-0.0067016236,-0.051166397,0.08282163,0.026148323,-0.026958426,0.054811552,-0.08285006,-0.011164346,0.08763805,0.06273076,-0.019994715,0.006312753,-0.073122874,-0.02084419,-0.021370512,0.008049065,-0.015605796,0.004274237,-0.09518171,0.021169055,0.012405938,0.0061008246,0.007597154,0.0023615037,0.043003265,0.11281699,-0.06693783,-0.06245353,-0.047405094,-0.012202178,0.082596,0.15129653,-0.012599418,0.027837424,-0.031100268,0.039319944,-0.008976514,-0.042843763,-0.026594047,0.09815298,0.012396564,0.02580749,-0.051351525,-0.03242112,-0.0691883,-0.05773164,-0.052810337,0.041136228,-0.019579936,0.033562403,-0.061770845,-9.606262e-34,0.0822427,-0.013398272,-0.007055034,0.014848666,0.033326022,0.03789397,-0.09744276,-0.0068975845,0.0015850941,-0.04296746,-0.027638385,0.018232293,0.019623887,0.016785897,-0.04466589,-0.075188644,-0.027363747,-0.023630107,0.011720994,-0.041500054,0.016528603,0.03936922,-0.038764477,0.06641862,0.0059470776,-0.023260664,0.0022128567,0.04284973,-0.0013029757,-0.012733736,0.04547425,-0.039804168,-0.06763797,-0.0045218356,0.012094537,0.03210199,-0.04462606,-0.0055012256,0.070704766,0.07668656,-0.040870592,0.0023631328,-0.01994223,-0.014490672,0.012869675,-0.07297381,-0.035697047,0.043241013,0.034433186,0.012235601,0.05123587,-0.05999049,0.047164977,0.009479032,0.013478261,0.031148115,0.03176757,0.0020403482,-0.003298709,0.12509254,-0.04658071,0.06124049,-0.007952322,0.01458353,-0.100619994,0.047659494,-0.07156297,-0.08200725,0.06609747,-0.026507674,-0.03401028,0.07629887,0.11987092,0.0040949527,-0.0023617628,-0.00080504344,0.013963437,-0.018067533,0.0502765,0.06851403,0.035170693,-0.02849539,-0.03539715,0.0339102,-0.053751767,0.042043764,0.022198364,-0.078763396,-0.037480693,0.04174644,0.012070589,-0.013208838,-0.019631531,-0.13108444,-0.00955501,-1.4288843e-33,0.050911132,-0.0072116293,0.035931595,-0.049057312,0.0069160126,0.059675466,0.09464958,-0.09093995,-0.033210676,-0.10038645,0.069304906,0.022320118,-0.011514062,-0.024870642,-0.030799,-0.02875637,-0.054003116,0.022841195,0.01346703,0.015340012,-0.018169492,0.17600372,0.03270117,0.038970828,0.050323457,-0.061025668,-0.06376171,0.05938175,0.005967391,0.09475657,-0.02515505,-0.03671768,-0.113603055,-0.060143966,-0.025003823,0.06068944,0.024754582,0.012292152,-0.033909876,-0.013050992,0.01410322,-0.031705525,-0.012564193,0.047829814,0.009661334,0.05808067,-0.037656743,-0.064841755,-0.026010571,0.00869348,0.051964533,-0.008783197,-0.10975587,0.04202822,0.036801856,-0.019037455,0.011426673,0.018305298,0.037090544,-0.003725596,-0.055799454,-0.05596942,-0.0028192247,-0.10524098,-0.0049023135,0.03183204,-0.0020371543,0.0401163,0.11446211,-0.034184422,0.093229055,0.025668258,0.10207649,0.030206867,0.006480927,-0.10168021,-0.0632134,-0.032766193,-0.056097943,-0.06962031,-0.03317484,0.06272338,-0.08015004,-0.12141709,0.09052448,0.018867215,0.05204308,0.027981963,-0.02437564,0.059542503,0.0007780489,0.043802038,-0.037331603,0.028990388,-0.026610054,-1.7353889e-08,0.026868783,-0.03237936,0.06550283,-0.024128325,-0.016706385,0.07555708,0.07594999,0.00034985106,0.025252026,-0.025872638,0.037441976,0.084318705,0.02611199,0.0011552187,0.06272433,-0.017259628,-0.04324079,0.041534435,-0.06246489,-0.0521816,-0.11264818,0.03766648,-0.07650679,0.10015774,0.053641632,-0.02580137,0.04416866,0.019096943,0.04687465,-0.06638355,0.03827027,-0.023824377,0.050517023,-0.046625935,-0.014067489,0.062860414,0.0128357755,0.061311148,-0.089760326,0.036954578,-0.087788396,-0.116869874,-0.03758276,0.068056956,-0.017434463,-0.023332989,-0.0033400739,0.08807488,-0.0010134665,-0.012318964,0.07355578,-0.035382472,-0.00093298487,-0.11752044,-0.050388403,0.0057068537,-0.038417444,-0.032437436,-0.023425903,-0.0074290037,0.048513968,-0.0025686983,0.08616251,-0.047797803 +3.1.13.4,Cleaves poly(A) in either the single- or double-stranded form.,384,1.0,-0.03513896,-0.03145706,0.033096593,-0.019070808,-0.017492425,0.010036622,0.008980075,-0.034208912,-0.0009318166,0.013688571,0.03589044,0.032183997,-0.056767505,0.052906223,-0.024513684,0.0687945,-0.14287618,0.031247279,0.03155367,0.0875051,0.11011546,-0.0769181,-0.007937924,0.020533435,0.046537567,0.032548342,0.090879925,-0.00975026,0.028198415,-0.07930375,-0.080426715,0.011605141,-0.014999612,0.011104328,0.07787658,0.01047839,-0.007603299,0.012538393,-0.005904237,0.044989366,0.10863535,0.0139131835,0.0724624,-0.02720701,-0.036909234,-0.03869743,-0.0519278,-0.0068325484,-6.137331e-05,0.02968676,0.026106702,-0.043793153,0.00066063035,-0.010705093,0.012307802,0.027771441,-0.147447,-0.0048237205,-0.0014875518,0.009023076,0.019912694,0.048107676,0.017834906,0.086101614,0.04670084,-0.0069982135,0.0057245228,0.019042756,-0.062798046,0.009935111,-0.041270424,0.071503185,-0.09731462,-0.01717187,0.015431656,-0.004232696,0.022578096,-0.0664087,0.016349485,0.1111052,-0.10568509,0.04148442,-0.011120674,0.027564496,0.086284995,0.09497456,0.0379399,-0.031868067,-0.07047275,-0.033232145,-0.021541927,0.026016396,0.034820985,0.04403475,-0.048993785,0.08892225,0.033175927,0.020118358,0.025325181,-0.0059266104,0.009026827,-0.017531052,0.044690553,-0.05617096,-0.059043832,-0.038347173,-0.04596294,0.0022178106,-0.012606116,0.0076572415,0.017966576,0.017694639,0.066600665,0.041287076,-0.0762569,0.03072447,-0.06267968,0.037129395,0.07854831,0.030306026,-0.06702798,-0.044024557,-0.0015493879,0.08192076,-0.038702928,-0.036054492,-0.08258608,-2.5338387e-33,0.029061338,0.04230975,0.060903918,0.038764723,-0.06306259,-0.021992452,-0.02720929,-0.015774807,-0.11617877,-0.037039872,-0.10895696,-0.007663574,0.05522434,0.08241888,0.08645093,0.0047757295,0.054796893,0.04278456,0.018886972,-0.012689007,-0.008025038,0.12571709,0.037346996,-0.007252332,0.014926816,-0.052253146,0.03969008,-0.04686023,0.018985793,0.025969023,-0.0036819775,0.030194886,-0.034104276,0.061241806,0.025473423,0.008182407,-0.052672498,-0.018148268,-0.039213195,0.070965916,0.028386917,0.026459223,0.0658409,-0.0456467,0.055219915,-0.11332361,0.008108277,0.06810454,-0.08392618,0.005007623,-0.023886245,0.10154566,0.01829058,0.032390546,-0.04139586,-0.026033344,-0.002782837,-0.09811109,-0.08489178,0.04660861,0.01938915,0.10487592,-0.05073524,-0.042885933,-0.118716754,0.016594237,-0.020351501,-0.054048877,0.03679814,-0.03563658,0.023148369,-0.029090995,-0.055050712,0.010502875,0.005341387,-0.058197115,-0.03530859,-0.048162322,0.07700548,-0.009494221,0.021685,-0.014069528,-0.0022961858,-0.015270391,-0.09908431,-0.06047303,0.035456836,0.001441987,0.056858063,-0.004560892,0.016263742,-0.04862102,0.01588758,-0.08261273,0.007805159,1.3992208e-33,0.060703628,-0.08649834,0.02462196,-0.025998576,-0.055922113,-0.0041933684,0.026125923,-0.10757476,-0.038426843,-0.05326679,0.027364273,0.005069277,0.032315616,-0.040977705,-0.0022336822,0.04697431,-0.024085319,-0.021364834,-0.032609135,-0.05538058,-0.026091259,0.023399094,0.05127184,0.038582157,0.047702365,0.0146422265,0.0060351584,0.024070127,-0.030340903,0.039654676,-0.044031247,-0.02074357,-0.024167847,0.08236613,-0.04500795,-0.022513347,-0.019881874,-0.026155079,0.09025074,-0.012333613,-0.017947843,-0.043763775,0.06992699,0.10457927,0.011848028,0.017399998,-0.030605908,-0.029780773,0.049472384,-0.023246998,-0.040904757,-0.00145312,0.022036966,-3.8121223e-06,0.010247931,0.030688496,-0.07857419,-0.02248528,-0.045739602,-0.02659855,-0.035732266,-0.02329188,0.034466363,-0.03212804,0.059908308,0.004058106,-0.0039040153,0.006758762,-0.08479267,-0.13727807,0.12705916,0.04132025,0.008910155,0.02506602,-0.014295018,-0.062651545,-0.040123645,-0.09042456,-0.005210644,0.033652596,-0.07571825,-0.04090116,-0.02283582,-0.011039316,0.044916116,-0.0070923115,0.07022492,0.003861154,-0.029585812,0.00020228629,0.05375977,0.05512565,0.0150010055,0.12609948,0.057622742,-2.210829e-08,0.014706811,-0.055311825,-0.063816264,-0.06930303,-0.08010039,0.02644175,0.010253116,-0.04359731,0.04323896,-0.04175362,-0.0325981,0.01869739,0.015153789,0.09584854,0.09914356,0.03282489,-0.028617768,-0.021455634,-0.05318058,-0.10375897,-0.08764503,-0.025853548,-0.07457639,0.07897972,-0.06630005,-0.039806925,-0.019935884,0.010913829,0.0789856,0.077562235,-0.03004185,-0.0004269832,0.033577263,-0.0071030683,0.017551515,0.11997811,0.085536286,0.01478794,-0.003594205,0.09363114,0.121138014,-0.009889627,-0.008513047,-0.009637483,0.08422123,-0.03486813,-0.029432349,0.03732411,-0.05388249,0.115243405,0.06106176,-0.0024044884,0.014616291,0.022663541,-0.072830126,-0.008745156,-0.04449232,-0.06482995,0.026442967,0.028097743,0.0011359703,-0.00017700123,0.09728379,0.03883045 +3.1.14.1,Similar enzyme: RNase 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+3.1.15.1,Preference for single-stranded substrate. 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+3.1.21.1,Preference for double-stranded DNA.,384,0.99999994,-0.080137506,0.017935589,-0.002076864,-0.026644746,-0.064514615,-0.015707187,-0.044905324,0.11468376,-0.020987831,-0.0009646863,0.0861352,0.10566184,-0.091120586,0.02700903,0.012660805,0.03758952,-0.020976946,0.012673919,0.05311391,-0.053326357,0.043166414,-0.049729884,0.09945413,-0.018499304,-0.009593311,0.015752347,-0.037633114,0.09997691,0.014105378,-0.081066675,0.026700899,0.015960073,-0.048164885,-0.050319556,-0.0037431049,-0.051166486,0.0581357,0.05747549,-0.021624679,-0.027738139,0.07045598,-0.00051466934,-0.0094984295,0.072286375,-0.061762482,-0.063861646,0.027662158,0.007864839,0.03149192,0.06420278,0.04437856,-0.006325077,-0.0061679548,0.025046285,0.053199332,0.08412965,-0.14511211,-0.020518258,-0.025206953,0.02607478,0.009003758,0.023268152,-0.018438434,-0.01450702,0.13989615,-0.05139936,0.07679876,-0.05240881,-0.026807848,0.01965347,0.03188741,-0.007735785,-0.0114505375,0.03601899,-0.023289192,-0.015387524,0.0070443107,-0.06563581,0.0019847304,0.09251693,-0.06944602,-0.08686725,-0.012010251,0.008154466,0.008102935,-0.017813444,0.033870514,0.015699513,-0.065092534,0.049201354,0.027923878,-0.025675885,0.09825215,-0.019736899,-0.10458274,0.089838594,-0.022676295,0.06715754,-0.0023285546,-0.053151175,0.06667132,-0.09478519,-0.018632893,0.043591723,0.00026642784,-0.105652966,0.0007930741,-0.0734531,0.07776446,-0.01890088,0.023848306,0.08572947,-0.013403393,0.058130667,-0.102985404,-0.05898025,-0.03725454,0.026662884,0.03627404,-0.0032871878,-0.025654653,-0.0574643,0.056118138,0.014288322,-0.02137891,-0.0740297,-0.03814407,-5.1435004e-33,-0.053394444,0.12533793,0.0486956,0.021355072,-0.054039642,0.018150117,-0.054234777,0.02012943,-0.08913027,-0.013862799,-0.06722,-0.036517095,0.053648572,0.094622724,-0.012980822,0.03917098,-0.0073633157,-0.0047476045,0.0014952181,0.0015141148,0.018742718,0.024174968,0.05402766,0.03886827,0.09978812,-0.10139303,0.037002604,-0.012693116,0.093937755,0.011709859,-0.016078828,-0.048085105,0.03579252,0.055659708,0.06373042,0.085025646,-0.033424024,-0.051496472,0.025849989,0.07909294,-0.052096155,0.032713037,0.09178317,-0.069302894,0.11777513,-0.05636518,0.0032662842,-0.037032638,-0.13522437,-0.035382085,-0.033798933,0.0071039167,0.006072573,0.055831395,0.030263053,-0.0076104878,0.026855445,-0.035572518,-0.057769895,0.084477626,-0.055900224,0.033552215,0.019075107,-0.074656,-0.0047160257,0.035739303,-0.0010521531,-0.06617634,0.0021279631,0.0094601605,0.07170909,-0.0835525,0.018263232,-0.034373954,-0.034536008,0.0018252187,0.01201971,0.0076675382,0.051899668,-0.019845665,-0.059523087,0.0063455473,-0.059695147,0.0121531,-0.031156948,-0.0040251967,-0.018818334,-0.049987912,0.054370277,0.07732748,0.09683664,-0.023316195,-0.0022656545,-0.09695468,0.018028356,2.7848317e-33,0.06677449,-0.090305835,0.04536111,0.044530686,-0.012104373,-0.030615704,0.04441335,-0.06467246,0.007424579,-0.06286101,0.057651855,0.008837651,-0.034075294,-0.017036118,0.041823737,0.033211127,-0.026416564,0.016699787,0.077742636,-0.055001263,0.0060959775,0.04710041,-0.038982116,0.083972596,0.045632258,-0.020621777,-0.07624627,-0.006939604,0.00031227688,-0.05213318,-0.12517679,0.012499702,0.036184408,-0.051315453,0.033391114,0.04228331,0.026029285,0.041640732,0.008032881,0.02999791,-0.06778592,0.14361823,-0.055365335,0.104424514,0.015781404,0.030040434,0.008947291,0.005271428,0.068530574,0.0072578825,0.04788537,-0.0012425453,-0.06076031,-0.06716386,0.010707384,-0.06935918,-0.002876103,-0.025721407,-0.0015195837,0.051150914,-0.0032846588,-0.03195936,-0.0129812565,-0.031324916,-0.051081754,0.013839765,0.023422262,0.05331951,-0.037356846,-0.035403088,0.001191927,-0.05288477,0.05696314,-0.016293636,-0.03163168,0.020742513,-0.06053079,-0.013388991,0.023100153,0.033408057,-0.09426413,-0.021533567,-0.06356282,0.043807287,0.07968245,0.007150325,0.016082773,-0.006035906,-0.051987007,-0.06759844,0.012210359,0.023513265,-0.054217946,0.028798075,-0.030026803,-1.5529551e-08,0.065292776,-0.039523214,0.00922456,-0.045570184,-0.0041877916,0.032954145,-0.087157995,0.021055074,0.070671536,0.015318166,-0.018751208,0.09184451,-0.036310382,0.054607008,0.081350714,0.024477232,-0.030511018,-0.054529108,-0.05547761,0.0750978,-0.03022452,0.06924167,-0.15459523,0.023554774,-0.048319776,0.040113226,0.061307598,0.009004801,0.01220874,-0.014278835,0.018852947,-0.040339086,-0.022272687,0.07049358,-0.023585329,-0.0703457,0.024635928,0.050222263,0.00875258,-0.018306252,0.081848286,-0.018559042,0.014944255,0.02307577,0.027216712,-0.048371684,0.061192475,0.030186273,-0.049990077,0.028326888,-0.042385425,-0.058129713,0.05428742,-0.048467573,0.018540315,0.0024395774,-0.0133602,0.020326586,-0.06333384,0.02682813,0.05627641,-0.023877747,0.026549926,-0.06297622 +3.1.21.2,"The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites. It specifically cleaves the DNA backbone at AP sites and also removes 3' DNA-blocking groups such as 3' phosphates, 3' phosphoglycolates, and 3' alpha,beta-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes. It is also the only known repair enzyme that is able to cleave the DNA backbone 5' of the oxidative lesion alpha-deoxyadenosine. The enzyme has a strong preference for single-stranded DNA.",384,1.0000001,-0.06896274,-0.039881784,-0.012118445,-0.045442864,0.041563608,-0.013594845,-0.07469548,0.027343482,-0.0341963,0.059693586,0.032729305,0.15012735,-0.110994786,0.007728208,-0.077944495,0.10135215,-0.08852434,0.017034212,-0.011229289,-0.05244942,0.015275108,0.056419253,0.038616836,-0.012858547,0.0154049955,0.038942993,0.023128217,0.007482789,-0.030032026,-0.123934016,0.0006581386,-0.09960755,0.019708252,-0.028067566,0.033851765,0.08478313,-0.009041994,-0.04095633,0.007724829,0.0205316,0.048001286,0.025997758,-0.07225026,0.044660643,-0.07652931,-0.04510057,-0.011812113,-0.0077995597,0.034464743,0.059526395,0.04876012,-0.024268506,-0.03683082,-0.041168626,-0.004527007,0.04104656,-0.02210952,0.022130704,-0.026554644,0.055891197,0.05925897,0.006952672,-0.018253377,0.042183906,0.083799906,-0.071482055,0.1047506,-0.10007337,-0.07077553,-0.03579657,-0.020482842,-0.07930901,0.033045158,0.01346343,0.016505325,0.08612444,-0.06684848,-0.102195166,-0.02167135,0.06475299,-0.0045617786,-0.06162263,0.03704841,0.08038951,0.06400069,-0.0114498455,0.03387619,0.032107282,0.05165604,0.0014674945,-0.0355115,-0.012946022,0.014222924,0.00016038245,-0.05377307,0.09497968,0.0535655,0.0049891276,-0.032711625,-0.06241412,-0.037127655,-0.005360856,-0.0024987438,-0.057221312,-0.05445712,-0.016689861,-0.010711699,0.06872152,0.053140752,-0.024542673,-0.04229877,0.064614624,0.0372001,-0.008904285,-0.036560073,0.012132828,-0.036418308,-0.010120735,-0.024651177,0.029009646,0.021973662,0.010452218,0.06620174,0.060431853,-0.029637026,0.0059477035,0.0010930034,2.7610954e-33,0.055179175,0.063259244,-0.022190759,0.055210024,0.006925261,0.033084206,-0.07696345,-0.00828319,-0.09393777,-0.01850568,0.030292802,-0.052830055,0.088139266,0.024354812,-0.037217136,0.016212925,0.006879063,0.013021051,0.00010552569,-0.0019462082,0.03370888,-0.0071967253,-0.0018943137,0.01834207,0.02316104,0.057350982,0.020788917,0.09191624,0.0695044,0.003454586,-0.047620434,-0.070244,-0.050070062,0.024139812,-0.003093792,0.011610413,-0.033539396,-0.07878766,0.004911219,0.047782343,-0.0975197,-0.016052345,-0.017228898,-0.020811396,0.088775754,-0.094085775,-0.045225568,0.058712505,-0.079740316,0.025476968,0.027070032,-0.05082522,0.06130253,-0.00087505043,-0.07682636,0.04036005,-0.011003692,-0.010166015,0.0111895725,0.065466136,0.09634315,0.04539598,-0.02202478,-0.042727053,0.0012205386,-0.010969616,-0.00832933,-0.06353369,0.048082296,0.10910792,0.013663949,-0.06344102,0.04344925,0.083586775,-0.04511611,-0.022982273,-0.015205678,0.051880136,0.0141669065,0.034153778,-0.012953157,-0.03030132,0.022205193,-0.027924705,-0.029169722,-0.046213735,-0.0578949,-0.051522706,-0.00217124,0.025255378,0.09653251,-0.048787046,-0.019871933,-0.034927577,0.011264596,-4.0823376e-33,0.11351738,-0.16715069,0.07361737,-0.04829309,-0.0444838,-0.012761172,0.037339177,0.028433902,0.04877876,-0.022412784,0.04911876,-0.027289093,-0.025886685,-0.10399696,-0.0111710355,0.01706997,-0.0013307426,0.022611387,0.0054183453,-0.0052548107,0.05238702,0.1128908,0.020033704,0.048061654,0.028674008,-0.029013513,-0.07195339,-0.043995533,0.030860988,0.036264945,-0.04321319,-0.011292299,-0.011898596,0.027292002,0.0034653458,0.10536087,-0.06744421,0.00453593,-0.014822663,0.01125801,0.009336181,0.045655426,-0.014328078,0.029077815,0.056381144,0.08271231,-0.07205023,0.031289797,0.023710705,-0.08383634,0.024153227,0.005088189,-0.037651576,0.019348884,0.07418262,0.012885288,-0.0036352705,-0.06805437,-0.06343995,-0.0059681027,-0.0353174,-0.026859038,0.0634321,0.09395165,0.028823443,0.056612577,0.012592349,0.015732171,-0.01652925,-0.016712734,0.07326024,0.00016047395,-0.019962111,0.017679181,0.0064585158,0.043935232,-0.102009326,-0.0023064723,-0.016737007,-0.043904196,-0.013680368,-0.027410932,-0.069473036,0.0067469543,0.09743603,-0.05895005,0.015399471,0.11238149,-0.031020733,-0.046456654,-0.015700033,-0.0030830628,-0.038764797,0.015340969,0.030735943,-4.3779334e-08,0.01120674,-0.032862738,0.007451085,-0.08415562,-0.014499626,-0.029953158,0.02487618,0.05539065,0.14807284,-0.020521263,-0.0732589,0.10631165,-0.02723456,0.06449056,0.0005337559,-0.0047224886,-0.03349156,0.080125436,0.0014819357,-0.004663266,-0.12400573,0.02504969,-0.08361349,0.028826926,-0.015432497,0.04465825,0.024802094,0.010983553,0.0061177425,-0.0702117,0.034371585,-0.046840075,0.015377586,-0.02389964,-0.045340694,0.06055753,0.04084894,0.009635233,-0.0544362,0.08059273,0.018591987,-0.043274097,-0.0014090142,0.0116237635,-0.009726234,-0.005431084,-0.005053312,0.008326074,-0.07078619,-0.02242162,0.087082826,-0.049128648,-0.06545372,-0.121472806,-0.118464574,-0.036885478,0.04013421,-0.058396347,-0.014863449,-0.07443583,0.03704856,-0.0052687973,0.17309037,-0.063780904 +3.1.21.3,"This is a large group of enzymes which, together with those now listed as EC 3.1.21.4 (type II site-specific deoxyribonuclease) and EC 3.1.21.5 (type III site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC 3.1.23 and EC 3.1.24. They have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. They are multifunctional proteins that also catalyse the reactions of EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] and EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase].",384,1.0,-0.06554898,-0.008560208,-0.013670902,-0.102049254,0.07620852,0.00994318,-0.0800327,-0.0015716661,0.035763294,-0.03140138,0.014079157,-0.08081495,-0.07327799,0.025884487,-0.00089458976,-0.016752722,-0.12162668,0.0037974205,0.032307032,-0.06267279,0.030117573,0.092141666,-0.012483491,0.003752755,0.024286967,0.05028262,0.034916334,0.04563955,-0.033970084,-0.055567678,0.033960525,-0.081219114,0.031800777,-0.023921493,0.103074744,0.103311636,-0.0728728,-0.04641045,0.041802593,0.02863377,0.090288855,0.025814937,0.016360726,0.017321868,-0.028398281,-0.020373562,0.014849037,-0.012884097,-0.010137885,-0.08187877,0.06254411,-0.018101254,0.002303931,0.04146821,0.0010378172,0.005353482,-0.046264153,-0.0005188762,-0.017027684,-0.0059102774,0.048673708,-0.059105605,0.043323334,-0.036974076,0.05360476,-0.01920361,0.036843017,-0.07792532,0.0558961,-0.06274316,-0.084170476,-0.0763443,-0.02630961,0.097493105,-0.022156393,0.048093516,0.00025415898,-0.029800545,0.005685904,-0.06642269,-0.013499732,-0.036614377,0.03994347,0.014095422,0.024625806,-0.064591855,-0.0013276607,0.016470842,-0.0029050063,0.055372007,0.020944392,-0.079010025,-0.001263884,-0.02150968,0.01276252,0.083206914,0.057957772,0.10923955,0.032545876,-0.033791795,0.035047304,0.09590896,-0.044884328,-0.04016941,-0.016902504,0.011650194,0.0017126433,0.059175044,-0.0019501756,-0.026878895,-0.029294098,0.011727427,0.033339478,-0.028948402,-0.013894154,0.07661815,-0.012452964,-0.032323256,0.041666456,0.02140101,0.01898093,-0.06412266,0.11932072,0.042550668,-0.015307815,0.04347623,-0.12712784,3.8942177e-33,0.028527305,0.01604867,0.014857672,0.012485985,-0.011785187,-0.00964961,-0.097342335,0.07833894,-0.10817028,-0.019581515,-0.04295703,-0.039105985,0.08999588,0.004380579,-0.058050815,-0.011012405,-0.077533536,-0.016402472,-0.012685971,-0.030107772,-0.020167459,-0.0005676501,0.0010444402,0.035595812,0.038246114,0.024968857,-0.04936674,0.038041834,0.08157606,0.0038793746,-0.027242798,-0.10766382,-0.06695997,0.03408011,0.029847283,0.02770404,0.0023615898,-0.0709141,0.052154873,0.054322034,-0.003295752,-0.022402355,-0.0008967599,-0.067963436,0.048877437,-0.02465671,-0.028501185,0.06972801,-0.009098971,0.043867297,0.05347923,-0.08673396,0.06929431,-0.08094336,-0.03716552,-0.001934941,-0.053067874,-0.0031219441,0.024480717,0.11839171,0.027068121,0.06518472,-0.0699362,0.013199037,0.02401753,0.025825584,-0.09169378,-0.033985235,0.046212472,0.0676349,-0.008739822,0.002913137,0.097439915,0.006183232,0.08460327,0.018594256,-0.059530403,0.036363844,-0.037630156,0.11054769,-0.04528189,0.0015304472,0.016787326,-0.049261525,-0.04367758,-0.054055534,-0.03957447,-0.08782544,0.011650827,0.0610896,0.024868794,-0.036872752,-0.07251341,0.017706603,0.0015903007,-5.4018715e-33,0.07867375,-0.040143073,0.0077024875,-0.10580683,-0.034470636,0.037505064,0.011616244,-0.0006038096,0.036944814,-0.03743689,0.08782443,-0.058567088,0.03249336,-0.11893438,0.013222277,-0.01107845,-0.05561895,0.04411154,0.026755951,0.07391314,0.065992974,0.057512958,-0.06744065,0.08167891,0.04545905,0.0065700277,-0.019405957,0.025266796,0.04952987,0.019594949,-0.116762884,0.043540087,-0.0015947148,0.04796047,-0.05264689,0.023518158,-0.07353983,0.0038418043,0.0047606467,-0.017840903,0.04355818,0.103500776,-0.048859134,0.05112732,0.009069348,0.10892445,-0.060110167,0.10598605,0.0022382364,-0.03523486,-0.029681511,-0.06231946,-0.027372994,0.015536374,0.025472594,0.05486451,-0.025444027,0.042268954,0.0111363195,0.007245766,0.010776163,-0.07643161,0.010101375,0.04873925,0.07018433,0.0067284266,-0.07617682,0.005387601,-0.014285318,0.034893814,0.055754825,-0.019215783,0.010264307,-0.05274853,-0.013185756,-0.010309693,-0.09641669,0.04813527,0.0006586773,-0.06374819,0.02319005,0.04075967,0.010205876,-0.025004888,0.07255491,0.05117729,-0.011660924,0.13053639,-0.038981285,-0.00030033084,-0.057773188,-0.007981248,-0.05997291,0.082160704,0.025067199,-5.7845693e-08,0.079808444,-0.083275445,0.035097912,-0.08012943,0.055516742,0.08301099,-0.02329524,0.03049382,0.09065256,-0.003728014,0.003172558,0.040776975,-0.012043573,-0.024527255,0.05423009,0.012160289,-0.05008001,0.045927953,-0.011748466,0.018444978,-0.036183074,-0.011909312,-0.11001927,0.049241472,0.028293066,-0.038516413,-0.0087363245,0.08605379,-0.00941541,-0.073517144,0.022947447,-0.042753097,0.012136966,-0.046479613,-0.017857153,-0.0045606047,-0.08242356,-0.059010543,-0.05779926,0.04785477,-0.011193707,-0.0451018,-0.061609935,0.0033734068,0.020900328,-0.005726919,-0.019322937,0.049823064,-0.06841813,-0.048267134,0.02207292,-0.077916645,0.026802626,-0.055530194,-0.106675684,0.027272409,-0.036512405,-0.07136893,-0.013345609,-0.028905122,0.024902064,0.009613222,0.15247066,-0.028027315 +3.1.21.4,"This is a large group of enzymes which, together with those now listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease) and EC 3.1.21.5.",384,1.0,-0.022350607,-0.05204118,-0.055308614,-0.02260885,0.078230366,-0.017691128,-0.025560057,0.00829959,0.0051594544,-0.059495304,0.0660279,-0.084555425,-0.08207161,0.025890587,-0.045269866,-0.010474075,-0.10048836,-0.049152978,-0.019396044,-0.046109483,0.008474175,0.05399017,0.0049087415,0.032367915,0.04220736,0.01831677,0.017151173,-0.00156334,-0.008758222,-0.102402784,0.047188368,-0.05727541,0.09043962,-0.011724742,0.07096642,0.051500753,-0.09749371,-0.08388354,0.018028725,0.07729745,0.06277903,0.030418893,0.044343695,-0.032835282,-0.049456045,-0.025216132,-0.040853567,-0.009334834,-0.007907898,-0.014114841,0.06784083,-0.084233366,-0.05458528,0.06950165,0.03000283,-0.0009847616,-0.043885883,0.022376193,-0.06344904,0.022493867,0.04836881,-0.00913618,0.0435489,-0.038193446,0.013415717,0.060405895,0.08060053,-0.11520056,0.0269349,-0.0755218,-0.07575318,-0.108163364,-0.0058774212,0.059536967,0.005317737,0.07239856,0.0048980913,-0.057919152,-0.0042787357,-0.048248094,-0.008237893,-0.03676369,0.0031475758,0.06758704,0.0026267238,-0.044767622,0.011515402,-0.0006637194,0.00438256,0.062815905,0.011283193,-0.034917362,-0.0055535384,0.028633155,-0.011852218,0.090849414,0.01858372,0.13063857,0.043033265,-0.031650454,-0.007829211,0.084992126,-0.009305917,-0.04020021,-0.04627049,0.012015791,0.056855656,0.03756134,0.011096677,-0.029708795,-0.035225324,-0.026746467,0.026639545,-0.027286861,-0.038906183,0.07576395,0.037112534,-0.0035336413,0.052765522,0.05290213,0.10650419,-0.021112282,0.12863791,0.016608752,-0.04294957,0.074340604,-0.13849153,-6.913799e-34,0.017576385,0.031023456,0.036203258,0.0015551406,-0.018558644,0.009818533,-0.08413517,0.06629395,-0.10009091,-0.051348157,-0.08023612,-0.008852954,0.07472335,0.045170862,-0.05897482,-0.05528438,-0.057462465,-0.00764386,-0.044828784,-0.006839679,0.049012743,0.048695236,-0.08286584,0.051181372,0.004662724,0.0202803,-0.053014066,0.0761756,0.06406422,-0.0014301437,0.024743682,-0.13150986,-0.07913643,0.0066106813,-0.015595247,0.033318043,0.0055976924,-0.04504918,0.034678932,0.05122624,0.022568095,-0.011041298,0.019328335,-0.06542804,0.051270735,-0.03640691,-0.054821443,0.09032342,0.0455403,0.022103546,-0.011616946,-0.06745591,0.07905822,-0.04663474,0.019276233,0.009938052,-0.029723288,0.07612952,0.0588341,0.0643017,0.041923,0.10103448,-0.05585486,0.004813898,0.012619603,0.040021095,-0.08393275,-0.026497718,0.006944194,0.002271561,-0.060465947,0.022330357,0.06399364,0.021655144,0.05263507,-0.02477757,-0.07809805,0.016354281,-0.031025022,0.07040883,-0.099302195,-0.019448,0.025791353,-0.047424484,-0.05427394,-0.022380881,-0.0666344,-0.042394377,-0.009904662,0.04662868,-0.038668722,-0.020286255,-0.05113936,0.009671337,-0.03158822,-8.946612e-34,0.027396465,-0.024974782,-0.0017860477,-0.07193232,-0.009479893,0.08052384,0.021837154,0.037891272,0.08106748,0.0292474,0.10897119,-0.018613689,0.028801532,-0.12516904,0.047818772,0.013491966,-0.092410885,0.015991732,0.01914177,0.054825246,-0.0074337884,0.044386804,-0.030663982,0.06224324,0.03364993,0.03409104,0.023713367,0.016797693,0.08192582,0.010424739,-0.113225676,0.009975184,0.048303843,0.05583597,-0.072323725,0.014559515,-0.06275571,-0.027631566,-0.020086756,-0.027168388,-0.027705906,0.026641982,-0.014003032,0.05849712,0.018273668,0.11549851,-0.026596868,0.055259373,0.010381681,0.015029852,-0.04460125,-0.014678472,-0.011904042,0.025077127,0.008801367,0.040593848,-0.024491996,0.059529435,-0.024649946,0.008647646,0.030797426,-0.027211051,0.050488733,0.03440075,0.012137927,-0.003535617,-0.08917063,0.0010457115,-0.007936062,0.02333925,0.09222219,-0.020158391,-0.03714453,-0.060415752,-0.04222883,-0.06750342,-0.0784736,0.045036156,0.0061290837,-0.080713704,0.065325454,0.03215008,0.02001162,-0.007781159,0.04904231,-0.02897768,0.01762626,0.12591816,-0.046721395,0.034414295,-0.08983874,-0.016334113,-0.109562755,0.07253113,0.031723164,-3.234488e-08,0.086850025,-0.03351816,0.040560424,-0.039811525,0.10014262,0.030505653,0.008574963,0.021813573,0.016902825,0.0519113,-0.011390234,0.056475572,-0.0033202597,-0.02752273,0.060269035,-0.013476055,-0.05610485,0.053692475,0.008121964,0.02571833,-0.0055057467,-0.002101737,-0.059432235,-0.023011718,0.0123052085,-0.04192857,0.020102814,0.0854831,-0.051029813,-0.047803696,5.6775767e-05,0.011439796,0.0082637,-0.051496882,-0.04461282,0.042000674,-0.110974625,-0.03272116,-0.05279784,0.046075545,-0.027463626,-0.09191393,-0.028141124,-0.0041345092,0.00010371504,-0.0014668901,-0.010365928,0.02398703,-0.012784177,-0.060979236,0.00022363561,-0.03998125,0.0054983124,-0.0015036546,-0.11738755,0.06741737,-0.035466548,-0.08262213,-0.008161692,-0.04844107,0.023504987,-0.020107005,0.14782237,0.007391041 +3.1.21.5,"This is a large group of enzymes which, together with those now listed as EC 3.1.21.3 (type I site-specific deoxyribonuclease) and EC 3.1.21.4 (type II site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC 3.1.23 and EC 3.1.24. They have an absolute requirement for ATP but do not hydrolyse it; S-adenosy-L-methionine stimulates the reaction, but is not absolutely required. They recognize specific, short DNA sequences and cleave a short distance away from the recognition sequence. These enzymes exist as complexes with enzymes of similar specificity listed under EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] or EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase].",384,1.0,-0.07520828,-0.016087564,-0.023637649,-0.07751263,0.03414822,0.0037464318,-0.0824856,-0.0020522254,0.0041894927,-0.036548518,-0.005745204,-0.07524318,-0.055643987,0.06299151,-0.022236902,-0.033093866,-0.074994884,0.009691023,0.04265631,-0.05163245,0.052094005,0.09027623,0.01773128,-0.0007540866,-0.0014387765,0.0388339,0.030847969,0.06478466,-0.019135324,-0.046114467,0.022343041,-0.076234154,0.061878804,-0.02541786,0.08487423,0.10995947,-0.07256977,0.0050205016,0.06939931,0.021846797,0.10466722,0.00011016565,0.036332417,0.023430763,-0.03410643,-0.051404186,0.009444746,-0.021989401,-0.015279189,-0.05022152,0.03306874,-0.04532882,0.009401813,0.004332494,0.0018080709,0.017250331,-0.030710636,0.040014483,-0.0008833083,-0.030954804,0.059135698,-0.09157574,0.04463486,-0.04396249,0.062633425,-0.004865258,0.02801936,-0.07813236,0.07443804,-0.09149607,-0.040705945,-0.065712675,-0.022776682,0.09161763,-0.037455052,0.037715904,-0.0149496365,-0.0039853617,-0.027749872,-0.0638636,-0.0050832327,-0.052908532,0.06972649,-0.0058305664,0.026883561,-0.046956856,-0.0067912037,0.039165556,0.006812278,0.051309284,0.0030922212,-0.09379605,-0.021885958,-0.043537457,0.042399265,0.06694448,0.0719853,0.11111263,0.010981196,-0.022314703,0.039667513,0.08200198,-0.08748494,-0.023811772,-0.0048016957,0.0325277,0.016875183,0.026422113,-0.004152593,-0.018302212,-0.05509395,0.028156247,0.06145432,-0.015948335,-0.03713891,0.08644287,0.0037282244,-0.030813335,0.023776263,0.0074397055,0.019940794,-0.05543425,0.13297653,0.014464835,0.017961983,0.067707494,-0.096696585,5.160929e-33,-0.008081789,0.010587022,0.009330495,0.014843692,-0.0023044678,-0.018911654,-0.070640154,0.054475494,-0.07092855,-0.039604776,-0.036826763,-0.02311499,0.07358628,0.009671109,-0.060029645,0.03261575,-0.058912076,-0.035034068,0.0040534902,-0.034223955,-0.008348982,-0.019221209,0.001112772,0.028102582,0.016152415,0.013884781,-0.015173154,0.04368442,0.09955017,-0.003076999,-0.026105464,-0.12813146,-0.03734661,0.027517343,0.03542765,0.05375336,-0.03818456,-0.06564657,0.077455096,0.040644694,-0.03291562,-0.023110287,-0.0021421975,-0.07677827,0.057879027,-0.015582068,-0.01729366,0.058001965,-0.035160057,0.06477872,0.061624125,-0.095269896,0.04621551,-0.088512056,-0.04591225,-0.0008835105,-0.022494769,0.0063992245,0.031552076,0.12876798,0.03153752,0.05758433,-0.05278595,0.024739204,0.03637894,0.04370976,-0.09849132,-0.033488814,0.026284106,0.06349427,0.0039122333,-0.0039233738,0.045156028,0.014100096,0.07479156,-0.0010051725,0.0023637258,0.02126019,-0.065373845,0.080748945,-0.01965499,0.017721698,0.04636407,-0.018134164,-0.045133743,-0.034299783,-0.035003535,-0.08493787,0.008433048,0.04012103,0.038683213,-0.029291105,-0.08861195,0.007317916,0.04646198,-6.0175308e-33,0.06208273,-0.03818498,0.00773276,-0.1277725,-0.04918381,0.05907543,0.02987536,-0.042078808,0.047344327,-0.033931755,0.08116037,-0.046715606,-0.020684207,-0.13664578,-0.014807326,0.00635401,-0.0691158,0.0545599,0.0488368,0.0430891,0.07791808,0.07889607,-0.0741854,0.0801619,0.039876707,-0.005029257,-0.019807179,0.060907543,0.04035215,0.03125704,-0.09526442,0.037869558,-0.0047041527,0.041781466,-0.042879015,0.028877458,-0.09640015,0.008944086,-0.02276212,0.014547727,0.021371724,0.107523754,-0.060089752,0.051663782,0.008757293,0.08057393,-0.06448388,0.056133445,0.0065482087,-0.018424423,-0.03463078,-0.05530341,-0.033961076,0.024851205,0.048163984,0.0416439,-0.0121670775,0.017966473,-0.029005323,-0.033072233,0.016625073,-0.074918285,0.0013259437,0.046149816,0.06426057,0.010115018,-0.079662904,0.01614189,-0.013918867,0.056323215,0.052785467,-0.046118155,0.0060328,-0.044110533,0.00075289246,-0.017917592,-0.08013937,0.07543835,-0.046936292,-0.072234586,0.0004817016,0.084493585,-0.010784941,-0.03717959,0.11183007,0.048644878,-0.018817227,0.1167717,-0.029492673,0.005201199,-0.01841719,-0.022629533,-0.06731477,0.058045596,0.028767131,-6.2420725e-08,0.06273836,-0.077126905,0.04850373,-0.072432265,0.060375683,0.06873369,-0.025384601,0.015315558,0.072016925,-0.012264883,-0.016089303,0.039493203,0.0075523597,-0.014031043,0.065372765,0.035969615,-0.06714806,0.050268993,-0.022257082,0.031961855,-0.044023227,-0.035537027,-0.14258216,0.081907414,0.032794338,-0.03280412,0.010246054,0.055381857,-0.018287051,-0.072284445,0.053894993,-0.049465947,-0.014330051,-0.0514367,-0.036977764,-0.022593388,-0.05829509,-0.038216688,-0.059353855,0.005616426,-0.018489355,-0.04183054,-0.05343298,0.027733088,0.046497162,0.003777906,-0.021200841,0.03051672,-0.033937305,-0.020150103,0.020189824,-0.036029402,0.02471341,-0.06705181,-0.099553235,0.05118017,-0.030691244,-0.056666538,-0.028207015,-0.048764404,0.08040658,-0.0013130036,0.17132628,-0.050731745 +3.1.21.6,"Prefers CC sites in double-stranded circular and linear DNA. Greater affinity for double-stranded than single-stranded DNA. Produces nicks, generating double-stranded fragments with 5'- and/or 3'-protruding single-stranded tails. Requires magnesium ions for activity. The endonuclease from Chlorella-like green algae infected with NYs-1 virus 4[1] may be the same enzyme.",384,1.0,-0.08938247,0.0030101284,-0.07492173,-0.019636903,0.04187914,-0.042266242,-0.01732686,0.06595945,-0.049268655,-0.013434136,0.07074433,-0.018446056,-0.02851899,0.06883228,-0.014012582,0.058117095,-0.0813565,0.067392245,-0.011021932,-0.0078119156,0.1067526,-0.0062901075,0.0081800725,-0.021631705,-0.017357076,0.06743854,-0.02840244,-0.035193935,0.03890983,-0.13377537,0.009507089,0.032398824,0.08592711,-0.072428785,0.09355851,0.042967934,-0.0032875985,0.068550564,0.0026486553,-0.029749047,0.057449486,0.054117445,0.1398217,0.075178325,-0.066762984,-0.0069225887,0.016530553,0.025223516,0.03518688,-0.0044472227,0.032656565,-0.07706169,-0.054602645,0.0111568775,0.011360626,0.034218375,-0.11868497,-0.03605881,0.024145143,0.0052142767,0.077619486,-0.014305465,-0.0015127386,0.0104454765,0.119978845,-0.059458148,0.006056655,-0.049534947,-0.019331962,-0.05450982,0.01238634,-0.03582224,-0.11503265,0.08314405,-0.020683741,0.10895419,0.05621905,-0.07235267,0.02342638,0.11124356,-0.09853515,-0.047655303,0.12001135,0.026456827,0.011794823,0.04417521,0.03779947,0.012600977,-0.019161917,0.0650135,0.047479272,0.0022184765,0.016310576,-0.011333584,-0.066251256,0.06460641,0.04639401,0.010022423,0.029660467,-0.0110435,0.053327963,-0.08680691,0.02129545,-0.028713584,-0.013241711,0.012781588,0.018935455,0.023486106,0.066693164,-0.015960837,0.0041861786,0.074493766,0.0072550722,-0.050009802,-0.042713583,0.025386408,-0.0022842789,0.029772168,0.0009068365,-0.006938051,-0.028907932,-0.064117126,-0.020883113,0.0032337543,-0.042982265,0.0072432794,-0.019159393,2.0766494e-33,-0.02909122,0.0686709,0.011132066,-0.029137019,-0.02312909,-0.023820778,-0.019430202,-0.015115178,-0.09833453,-0.050463095,-0.0543287,-0.04126074,0.038676776,0.06972149,-0.04486992,0.00383462,0.011848089,-0.04643447,-0.032985326,0.010678713,0.004308124,0.044044893,0.0034234803,0.009753928,0.070151635,0.025791433,0.00458557,-0.009369295,0.09996646,-0.026908407,0.07297557,0.024910556,0.0039840355,0.118683524,0.039760597,0.12064437,0.026330758,-0.014870851,-0.010903299,0.032286,0.011229274,0.032725353,-0.03371487,-0.009898153,0.101928644,-0.09795235,-0.021217188,0.03577094,-0.034102403,0.032541655,-0.0037593578,0.052484076,-0.024206901,0.04364897,0.011020107,0.009390025,0.040108062,-0.016328832,-0.005778668,0.047349855,-0.016416116,0.062487524,-0.006052417,-0.05309552,0.01113112,-0.049699303,0.008901907,-0.033374667,-0.024505567,0.04134484,-0.022158824,-0.040514838,0.00868573,-0.028113592,-0.01320735,-0.033147983,-0.07082743,-0.025396103,0.088380344,0.007966924,-0.0155479945,0.042911615,0.04746051,-0.05434722,-0.109234,-0.041543685,-0.041275542,-0.079585575,-0.019563043,0.066039585,0.117737256,-0.02796955,-0.021519955,0.006560974,-0.021974761,-1.9937003e-33,0.031124644,-0.069904156,0.026659478,0.0011655496,-0.09598882,-0.01066277,0.03578982,-0.05687973,0.03838411,-0.015735673,0.045386016,-0.01793798,-0.050018527,-0.023501907,0.03371777,-0.004653756,0.06653583,0.13074872,0.011096117,-0.0343671,-0.008109287,0.13194254,-0.06757485,-0.010727721,0.07988466,0.0018982905,-0.020184949,0.0050555193,0.014274437,0.004308848,-0.058521554,0.035950292,0.056499474,-0.042710014,-0.023405999,0.031798974,-0.03918566,0.01356181,0.054185852,-0.025949357,-0.04622842,0.0037772541,-0.033328947,0.079267286,0.008329689,0.03972187,-0.010951115,0.10003126,0.041593913,0.02346433,0.05321626,-0.0067817993,-0.08464956,0.0041750306,-0.010061908,-0.045717698,-0.014408855,0.02253965,0.0314536,-0.048586,-0.037221782,-0.066754095,-0.014714899,-0.0769044,0.04585643,0.044764295,-0.0057238736,0.05205807,-0.0007156457,-0.03847897,0.03463266,0.0584236,0.05982973,-0.06432753,-0.021519875,-0.028822884,-0.07510548,-0.08626854,-0.019533306,-0.07289344,-0.069525495,0.0575442,0.03637782,-0.0014611749,0.1047622,-0.058197808,0.032064684,0.058708925,-0.046160303,0.0052385502,-0.02130431,-0.0022616677,-0.021981832,0.08541948,0.037239987,-4.1888676e-08,0.02647314,-0.068276756,-0.07996708,-0.06340663,-0.011473958,0.07981078,-0.0033388056,0.035420112,0.08415057,0.004169353,0.007891682,0.08296604,-0.051925495,-0.0039784196,0.100675665,-0.020111712,-0.06276927,-0.021955963,-0.04452362,0.009772111,-0.11708676,0.0053230105,-0.14941126,0.019405805,-0.08930633,0.020344041,0.09219346,0.10813645,0.02582453,-0.064544015,0.017344113,-0.008709902,-0.02489454,-0.023156466,-0.05834976,0.0041742637,0.004127898,-0.015974037,0.042025056,-0.0033182774,0.006681204,-0.026536826,-0.015217068,0.012407757,-0.057195686,-0.06481568,-0.014790914,0.013209775,-0.018744305,-0.026963376,-0.017107809,-0.09497712,-0.02958155,-0.078998744,-0.02444361,-0.009831794,0.06687639,0.029442811,-0.061265882,0.021576073,0.00037401947,-0.07533988,0.1516362,-0.06300161 +3.1.21.7,Previously classified erroneously as EC 3.1.22.3.,384,1.0,-0.046908114,-0.034693588,-0.0039372635,0.02015786,0.06360385,-0.021007614,0.0048894156,0.0032856215,0.01087749,-0.025625465,0.0966657,-0.04534483,-0.014610284,-0.027606979,-0.0005142,-0.13335826,-0.0005490741,-0.08031737,0.0086627975,0.044252377,-0.012299834,0.080042675,0.016295727,0.04839857,0.018635608,0.012765555,-0.026175909,-0.006171269,-0.0036613976,-0.09105441,0.02417937,0.052505817,0.08553537,-0.019124802,0.03805306,-0.016967945,-0.054447986,-0.13209268,-0.032055836,0.07941808,0.024210786,-0.0015375275,0.05607865,-0.007660209,0.0103823645,-0.013965948,-0.050763983,-0.045564782,-0.07480049,-0.042583786,0.020681635,-0.026956089,0.011525589,0.057431728,-0.011551094,-0.0038756945,-0.084761515,0.026334427,-0.0069308216,0.025027085,0.017408593,0.034077715,0.06947424,-0.0059332885,-0.0005724573,0.035353165,0.0461811,-0.14559947,0.021208718,0.03592565,-0.06077461,-0.05634371,-0.0025977641,0.07335017,0.01667667,0.0688315,0.06440482,-0.0010401609,0.07605471,-0.09500124,-0.03675057,-0.09428118,-0.08744531,-0.01453773,0.015682064,-0.027950559,-0.017863916,-0.057494525,-0.047883913,0.023679294,-0.009439087,-0.12174679,0.062135026,0.08067359,0.0056907427,0.0526781,-0.00735226,0.10989613,0.012076703,0.007921377,-0.020009637,0.10416793,-0.038458087,0.06520378,-0.026569542,0.02313071,0.06234214,0.03872443,-0.036263898,-0.03674537,0.0054504694,-0.09220913,-0.052802276,-0.115942255,-0.0069856457,0.02285528,-0.03542233,-0.004163551,0.09776137,0.069469094,0.04445109,-0.022457061,0.032052137,-0.004829585,-0.03216373,0.03375848,-0.08000696,-1.9565668e-33,0.014562192,0.024592064,0.008682669,-0.033915255,-0.0050913948,0.056835815,-0.085109755,0.06222422,-0.01606455,-0.025791617,-0.020370366,0.04823661,0.03333293,0.014469016,0.0052813804,-0.0095052365,-0.055394456,0.056762144,-0.036738962,-0.048351258,0.059886176,-0.018098291,-0.039734468,-0.05662468,0.035749126,0.03072085,-0.036485516,-0.033938978,0.05091845,0.034720328,-0.00088483637,-0.05110293,0.0005603006,0.031685065,-0.05739312,0.0014880815,-0.023403818,-0.03173054,-0.031290367,-0.012549792,0.038025454,0.076012604,0.021501597,-0.05351476,0.059500627,0.024438716,0.009509419,0.059384853,0.05808736,0.026359156,-0.018683245,-0.014429985,0.08102239,-0.017770885,0.07027083,-0.034441665,-0.021612145,0.06719407,0.009439383,0.055654276,0.035926133,0.11718205,-0.00802613,-0.008733823,-0.012036368,0.067833886,-0.05075558,0.034554575,-0.0040012626,-0.051908735,-0.09728363,0.049733575,0.01873518,0.04109488,0.039064713,-0.0816734,-0.05686404,-0.016373033,0.001840058,-0.019190336,-0.11877498,0.019276462,-0.00050800917,0.05267924,-0.082296446,-0.014418799,-0.009884811,0.048610266,0.05752167,0.09397939,0.054752078,-0.012699069,-0.02956699,0.046212807,-0.09218858,6.6696636e-34,-0.028485069,0.03279844,-0.05693548,-0.018886998,-0.016492441,0.019511802,0.0035838825,0.07244273,-0.005494105,-0.0056317057,0.09400048,0.020149741,0.05231415,-0.11457868,0.064753614,-0.039320447,-0.13370758,-0.076331414,-0.012539556,0.11307635,0.04605527,-0.010040382,-0.030969653,0.09437746,-0.026243893,0.07406749,0.04828689,-0.01785635,0.022776315,-0.044668473,-0.056972805,0.016249016,-0.07809208,0.06940282,-0.031778734,-0.055003725,0.010400973,-0.06811057,-0.02036401,-0.07975891,-0.008898795,0.055088516,-0.07276781,0.08182343,0.019115385,0.059739035,0.13418947,0.089002885,0.053901237,-0.024856137,-0.08228498,-0.053017803,-0.009020447,0.055730876,-0.022285126,0.037419945,-0.09844356,0.051271968,0.008335844,0.058577344,0.07493861,0.027044225,0.045967944,-0.010253218,0.041970246,-0.043364555,-0.11649565,0.07344546,0.014768156,0.027974306,0.028653054,-0.04724912,-0.066241145,-0.083348654,-0.0057066185,-0.04962963,-0.045265514,-0.02956768,0.0015784636,-0.050909735,0.010645124,0.042978693,-0.0007885888,0.055725243,0.039284226,-0.064192474,0.034212958,-0.0033423814,-0.010666158,0.010233521,-0.04555531,-0.030047698,-0.12127618,0.112825915,-0.032961197,-2.2173857e-08,0.05986896,0.07071241,0.0036002162,-0.00028375877,0.0919788,0.010441349,-0.0073586307,0.027580678,0.015188619,0.047209322,0.016261736,-0.06251502,0.009215589,-0.033347666,0.076272056,-0.057837617,-0.07348531,0.08662465,-0.02835213,0.0030241567,-0.011839491,0.0049571083,0.010803144,-0.0737842,0.01600285,0.010645481,0.012577101,0.034381792,-0.018038996,-0.021338558,-0.008644374,0.024832858,0.0017168245,0.02676127,0.01581653,0.030858077,-0.045732222,0.032451224,-0.014718164,0.006919195,-0.041588407,-0.035343513,-0.07840263,0.058731973,0.06411574,0.017193649,-0.038515273,-0.009834902,-0.06137566,-0.09269184,-0.04850226,-0.041742124,0.009857631,0.042523295,0.021485807,0.016764447,-0.07090199,-0.07897407,-0.020306326,0.023122378,0.060183853,-0.09459617,0.011382358,0.076806866 +3.1.22.1,Preference for double-stranded DNA.,384,0.99999994,-0.080137506,0.017935589,-0.002076864,-0.026644746,-0.064514615,-0.015707187,-0.044905324,0.11468376,-0.020987831,-0.0009646863,0.0861352,0.10566184,-0.091120586,0.02700903,0.012660805,0.03758952,-0.020976946,0.012673919,0.05311391,-0.053326357,0.043166414,-0.049729884,0.09945413,-0.018499304,-0.009593311,0.015752347,-0.037633114,0.09997691,0.014105378,-0.081066675,0.026700899,0.015960073,-0.048164885,-0.050319556,-0.0037431049,-0.051166486,0.0581357,0.05747549,-0.021624679,-0.027738139,0.07045598,-0.00051466934,-0.0094984295,0.072286375,-0.061762482,-0.063861646,0.027662158,0.007864839,0.03149192,0.06420278,0.04437856,-0.006325077,-0.0061679548,0.025046285,0.053199332,0.08412965,-0.14511211,-0.020518258,-0.025206953,0.02607478,0.009003758,0.023268152,-0.018438434,-0.01450702,0.13989615,-0.05139936,0.07679876,-0.05240881,-0.026807848,0.01965347,0.03188741,-0.007735785,-0.0114505375,0.03601899,-0.023289192,-0.015387524,0.0070443107,-0.06563581,0.0019847304,0.09251693,-0.06944602,-0.08686725,-0.012010251,0.008154466,0.008102935,-0.017813444,0.033870514,0.015699513,-0.065092534,0.049201354,0.027923878,-0.025675885,0.09825215,-0.019736899,-0.10458274,0.089838594,-0.022676295,0.06715754,-0.0023285546,-0.053151175,0.06667132,-0.09478519,-0.018632893,0.043591723,0.00026642784,-0.105652966,0.0007930741,-0.0734531,0.07776446,-0.01890088,0.023848306,0.08572947,-0.013403393,0.058130667,-0.102985404,-0.05898025,-0.03725454,0.026662884,0.03627404,-0.0032871878,-0.025654653,-0.0574643,0.056118138,0.014288322,-0.02137891,-0.0740297,-0.03814407,-5.1435004e-33,-0.053394444,0.12533793,0.0486956,0.021355072,-0.054039642,0.018150117,-0.054234777,0.02012943,-0.08913027,-0.013862799,-0.06722,-0.036517095,0.053648572,0.094622724,-0.012980822,0.03917098,-0.0073633157,-0.0047476045,0.0014952181,0.0015141148,0.018742718,0.024174968,0.05402766,0.03886827,0.09978812,-0.10139303,0.037002604,-0.012693116,0.093937755,0.011709859,-0.016078828,-0.048085105,0.03579252,0.055659708,0.06373042,0.085025646,-0.033424024,-0.051496472,0.025849989,0.07909294,-0.052096155,0.032713037,0.09178317,-0.069302894,0.11777513,-0.05636518,0.0032662842,-0.037032638,-0.13522437,-0.035382085,-0.033798933,0.0071039167,0.006072573,0.055831395,0.030263053,-0.0076104878,0.026855445,-0.035572518,-0.057769895,0.084477626,-0.055900224,0.033552215,0.019075107,-0.074656,-0.0047160257,0.035739303,-0.0010521531,-0.06617634,0.0021279631,0.0094601605,0.07170909,-0.0835525,0.018263232,-0.034373954,-0.034536008,0.0018252187,0.01201971,0.0076675382,0.051899668,-0.019845665,-0.059523087,0.0063455473,-0.059695147,0.0121531,-0.031156948,-0.0040251967,-0.018818334,-0.049987912,0.054370277,0.07732748,0.09683664,-0.023316195,-0.0022656545,-0.09695468,0.018028356,2.7848317e-33,0.06677449,-0.090305835,0.04536111,0.044530686,-0.012104373,-0.030615704,0.04441335,-0.06467246,0.007424579,-0.06286101,0.057651855,0.008837651,-0.034075294,-0.017036118,0.041823737,0.033211127,-0.026416564,0.016699787,0.077742636,-0.055001263,0.0060959775,0.04710041,-0.038982116,0.083972596,0.045632258,-0.020621777,-0.07624627,-0.006939604,0.00031227688,-0.05213318,-0.12517679,0.012499702,0.036184408,-0.051315453,0.033391114,0.04228331,0.026029285,0.041640732,0.008032881,0.02999791,-0.06778592,0.14361823,-0.055365335,0.104424514,0.015781404,0.030040434,0.008947291,0.005271428,0.068530574,0.0072578825,0.04788537,-0.0012425453,-0.06076031,-0.06716386,0.010707384,-0.06935918,-0.002876103,-0.025721407,-0.0015195837,0.051150914,-0.0032846588,-0.03195936,-0.0129812565,-0.031324916,-0.051081754,0.013839765,0.023422262,0.05331951,-0.037356846,-0.035403088,0.001191927,-0.05288477,0.05696314,-0.016293636,-0.03163168,0.020742513,-0.06053079,-0.013388991,0.023100153,0.033408057,-0.09426413,-0.021533567,-0.06356282,0.043807287,0.07968245,0.007150325,0.016082773,-0.006035906,-0.051987007,-0.06759844,0.012210359,0.023513265,-0.054217946,0.028798075,-0.030026803,-1.5529551e-08,0.065292776,-0.039523214,0.00922456,-0.045570184,-0.0041877916,0.032954145,-0.087157995,0.021055074,0.070671536,0.015318166,-0.018751208,0.09184451,-0.036310382,0.054607008,0.081350714,0.024477232,-0.030511018,-0.054529108,-0.05547761,0.0750978,-0.03022452,0.06924167,-0.15459523,0.023554774,-0.048319776,0.040113226,0.061307598,0.009004801,0.01220874,-0.014278835,0.018852947,-0.040339086,-0.022272687,0.07049358,-0.023585329,-0.0703457,0.024635928,0.050222263,0.00875258,-0.018306252,0.081848286,-0.018559042,0.014944255,0.02307577,0.027216712,-0.048371684,0.061192475,0.030186273,-0.049990077,0.028326888,-0.042385425,-0.058129713,0.05428742,-0.048467573,0.018540315,0.0024395774,-0.0133602,0.020326586,-0.06333384,0.02682813,0.05627641,-0.023877747,0.026549926,-0.06297622 +3.1.22.2,Preference for single-stranded DNA.,384,1.0,-0.06887164,0.026150934,-0.017373675,-0.0063434355,-0.019519318,-0.0053421464,-0.024953408,0.106621884,-0.007336376,-0.010197531,0.08124771,0.08132842,-0.09287681,0.005366328,-0.0022151398,0.03139686,-0.06035213,-0.04536524,0.056482323,-0.006643314,-0.025409633,-0.025650792,0.08249768,-0.016126456,-0.014534207,-0.00058024074,-0.04102859,0.049318686,-0.0050270474,-0.10464189,0.024601318,0.035552144,-0.029417422,-0.037958357,0.012374752,-0.012090477,0.037090003,0.024391929,-0.038580053,0.008488913,0.08350781,0.03053912,-0.013959307,0.09981193,-0.06194064,-0.06419853,0.022050152,0.013041124,0.03455076,0.051267397,0.067245565,0.007656625,-0.016703371,0.009300927,0.018502982,0.050463732,-0.14721516,-0.03337049,-0.021593511,0.00769105,0.009906179,0.023476437,0.007774064,-0.039204724,0.18254036,-0.04458404,0.11416064,-0.042810414,-0.031362507,0.018759228,0.019149069,-0.0235789,-0.023159655,0.06332262,-0.02197228,-0.021231662,0.00046998047,-0.07469168,0.010522426,0.12381261,-0.08943686,-0.06053677,-0.023039471,-0.0016592363,0.014069214,0.003978979,0.03190381,0.041103147,-0.04088901,0.03464441,0.011598312,0.006815468,0.08872908,-0.04039133,-0.09259691,0.07948779,-0.029376116,0.06415563,-0.00019387889,-0.061948653,0.058490407,-0.08158265,-0.008329995,0.09105944,-0.0312188,-0.06392155,0.0037146914,-0.054669548,0.05948405,-0.021942487,-0.036897767,0.0219972,-0.025116771,0.043562073,-0.12679303,-0.073638104,-0.076674156,0.028229995,0.04164227,0.048440896,-0.06442723,-0.081576906,0.058917113,0.032843262,-0.020583553,-0.04149941,-0.0063760555,-5.6344093e-33,-0.04894409,0.08037753,0.034854352,0.017156942,-0.0506938,0.008645534,-0.038975615,0.04382713,-0.09908503,-0.002874843,-0.060311627,-0.010881998,0.051777612,0.034804966,0.0041097933,0.0904599,-0.01647825,-0.009668126,-0.022415776,-0.017051522,0.0062894532,0.061260354,0.023155466,0.0071986034,0.048357777,-0.11098538,0.02087836,0.01996071,0.04433876,-0.014371132,-0.037314504,-0.018203711,0.021775177,0.041477226,0.06842537,0.06411854,-0.031856414,-0.033553764,0.015714632,0.06024125,-0.06465251,0.033353675,0.08158283,-0.06407342,0.105954595,-0.005303013,-0.016451929,-0.044085946,-0.15189403,-0.025355767,-0.038622987,0.023856694,0.008192784,0.039171223,0.008351828,-0.037470754,0.020029588,-0.020886596,-0.056671277,0.031124054,-0.07442825,0.017667502,-0.019811584,-0.06823981,0.023125088,0.077186614,0.0011782643,-0.05285371,-0.006493515,-0.031748313,0.05921198,-0.07317639,-0.030340867,-0.071058005,-0.06444071,0.026044466,0.0069978037,0.024903847,0.038526144,-0.0059124553,-0.033419464,0.015976034,-0.07286814,0.021501662,-0.005136589,0.0083155045,0.011708721,-0.05227456,0.0702724,0.06331467,0.10859035,-0.036991674,-0.004197079,-0.12470522,0.030265715,3.1705665e-33,0.05546811,-0.10335777,0.044416625,0.042844456,-0.007292354,0.013365804,0.06748977,-0.03237741,0.016312357,-0.02273539,0.06525441,0.009389618,-0.065003954,-0.019855926,-0.0043660747,0.08497325,-0.038195074,0.006212331,0.042455003,-0.0048365737,-0.02320594,0.04073278,-0.050845247,0.075235836,0.020403137,-0.0071486966,-0.061980594,0.0018468584,0.0064669647,-0.061803404,-0.11572406,0.010395542,0.04542145,-0.075041935,0.014408163,0.054068282,0.010280776,0.07432761,0.060035508,0.053132143,-0.060726166,0.09520953,-0.016204271,0.07423272,0.026510628,0.0497829,-0.03512577,-0.007936567,0.035906523,0.045731097,0.06835908,0.03657402,-0.048532613,-0.11631862,0.00041332925,-0.060527425,0.020891018,0.006259253,-0.021425609,0.039519094,-0.016029617,-0.030440358,-0.014293686,-0.013512087,-0.02599875,-0.00039773827,0.07521614,0.028014844,-0.037875935,-0.06065477,0.019477986,-0.05164353,0.09394577,-0.008118767,0.007153024,0.020058146,-0.075617775,-0.03751416,0.016007392,0.016112229,-0.10421115,-0.013698797,-0.08302144,0.011501923,0.11346036,0.022228226,0.05183091,-0.023241716,-0.019388124,-0.026906317,0.029106576,0.005781133,0.011206355,0.0051361257,-0.046544258,-1.4895557e-08,0.08139857,-0.026852567,0.017637666,-0.05447699,0.0211948,0.07051577,-0.051590666,-0.0022413896,0.06835424,0.0545706,0.026778637,0.091783546,-0.06805245,0.100721605,0.10291378,0.02205527,-0.06828882,-0.070659,-0.04815273,0.09130725,-0.04678509,0.06735291,-0.13221543,-0.004133759,-0.03252255,0.011945292,0.08149076,0.019420218,0.020877173,-0.04248715,0.029046735,-0.040901136,-0.012261394,0.07165229,-0.009824501,-0.021478355,0.033516172,0.05709661,-0.018127687,-0.010866819,0.08531163,0.018309167,-0.018317822,0.0018789913,-0.009511097,-0.036006954,0.06250383,-0.00463842,-0.06687623,0.06907282,-0.01770992,-0.05811309,0.008112929,-0.049026866,0.02713976,0.0044589415,0.050047357,0.013715161,-0.049164772,0.019737532,0.05668201,-0.04574321,0.040628083,-0.05177483 +3.1.22.4,The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions.,384,1.0,0.027176572,-0.04556416,-0.08512642,-0.03280609,0.042065814,-0.049423013,-0.042016424,0.004466651,-0.018593052,0.006786315,0.06121777,0.021185307,-0.13500316,0.07141796,-0.00035522704,0.017325066,-0.15014713,0.027816808,0.009652047,-0.060884625,0.037099604,0.019029977,0.07687008,0.003517053,0.02003199,-0.02557363,0.008767613,-0.037563395,-0.026410012,-0.09312233,-0.011557181,-0.047762077,-0.048876792,-0.011111567,0.09474889,0.054716066,0.08330917,0.028517885,0.024763782,-0.06138147,0.07922499,-0.026887573,-0.053156767,0.083079726,-0.04078592,0.0122793,-0.023086706,-0.061088286,-0.035592433,-0.016519142,0.012003067,-0.04277523,0.042292908,-0.012393381,-0.008183182,0.0939142,-0.046837796,-0.0035709357,0.0110325,0.062330134,-0.008801031,-0.04820668,-0.00863162,-0.03564391,0.02963375,-0.044177253,0.10519467,-0.013162825,-0.056007408,0.003600499,0.018721806,-0.033453494,-0.051868536,0.047512773,0.058069978,0.047422495,0.0091412105,-0.0048242947,0.038876712,0.037090607,-0.0664481,-0.08116068,0.052380025,0.034122754,0.02393732,-0.019508637,0.03603133,0.0778026,-0.005379352,0.044630434,-0.046520513,-0.046319522,-0.018159468,-0.07685605,0.005987998,-0.0003042153,-0.031946898,0.089454904,-0.028028168,-0.04846744,-0.008197237,0.019195743,0.008446413,-0.026333375,0.06463219,0.043445617,0.041432925,0.05714572,-0.0029521177,-0.018851755,0.009169939,0.009317191,0.13701756,-0.043216877,-0.038487095,-0.03492148,-0.00023436206,0.008324722,-0.04370561,0.06544925,-0.011217024,0.05084173,0.06730951,0.05597281,-0.10342856,-0.007317594,0.044156484,3.0417274e-33,0.010301677,-0.0007161689,0.021028813,-0.050254162,-0.00197925,0.025540192,-0.062973656,0.037020862,-0.052247424,-0.014476816,-0.056201003,-0.0775267,0.03623403,0.077295244,0.037300333,0.053543195,0.07836185,-0.0396366,0.0014483976,-0.005529654,0.0550325,-0.017848114,-0.045120772,0.008210313,0.048273697,-0.030827982,-0.026178034,0.053930834,0.04946599,-0.022105552,-0.032749686,-0.07494492,0.03580919,0.104905605,0.052506782,0.07778058,-0.011592207,0.011823459,0.0075531756,0.0069127083,-0.0291515,0.004120483,0.00596727,-0.08360844,-0.0010025061,-0.0693271,0.053328108,0.027712712,-0.008613482,0.03799709,0.015281219,-0.015960652,-0.0492086,-0.024256293,0.005403222,0.036221817,0.024114348,0.05320409,0.03118489,0.004264382,-0.06757785,0.08601734,-0.056628536,-0.027419679,-0.011331923,0.047098666,-0.015406153,-0.051916428,-0.038822163,0.02776698,-0.03068394,-0.037795093,-0.014171454,-0.022418736,0.01864311,-0.0075727515,-0.05592841,-0.04421733,0.048782386,0.020006927,0.03615056,-0.12784491,-0.027028762,-0.014903432,-0.041097738,0.008283272,-0.059687298,-0.0032080656,-0.036769617,-0.028683897,0.018133817,-0.041920144,0.0250468,0.018725041,0.069318786,-4.7218234e-33,0.08701374,-0.00412807,0.11427433,-0.053684372,-0.072730616,0.12708311,0.0033519263,-0.018808942,-0.005534541,-0.029980406,0.12835811,-0.019912358,-0.051823515,-0.035804372,0.0070022363,0.014641186,-0.011928753,0.0793632,0.033364203,0.017832503,-0.069662385,0.14138365,-0.09816629,0.015615713,0.0764061,0.018398404,-0.062012658,0.094004445,-0.0100977495,-0.021357244,-0.076708555,-0.008897717,0.048022486,-0.058014046,-0.029926972,0.0420296,-0.0032832401,-0.027579289,-0.014001484,-0.0134727815,0.0021009096,0.05783673,-0.046904564,0.061885487,-0.0055420613,0.0801565,-0.11434654,0.030893035,-0.012570222,-0.019849343,0.014530472,0.07878115,-0.078028224,-0.06263086,0.05616947,-0.004109795,-0.009715135,-0.016609013,-0.030018011,-0.05435023,0.0140211955,-0.07601304,0.02466637,-0.018772509,0.06313666,-0.02251442,-0.059317343,0.08990661,0.011993535,-0.05829099,0.07032601,0.064498775,0.010533153,-0.034732386,-0.052193888,0.07594273,-0.13514918,-0.08019795,0.036699925,-0.055459756,-0.006582801,0.014673777,-0.039758954,0.0074997437,0.09828627,-0.040182717,-0.013557266,-0.0077851075,-0.05139942,0.041399732,-0.01883917,0.036540516,0.0031229022,0.104076765,0.03118306,-3.147664e-08,0.11312621,0.037590317,0.0015231882,-0.09338126,-0.0149560645,-0.034387812,0.040390573,0.032641392,0.037020925,0.11184129,-0.031699385,0.043065973,-0.0896778,0.039437804,0.055887423,-0.025680726,-0.050427157,0.010729815,-0.013628466,-0.019712683,-0.043458987,0.024472527,-0.13665454,0.06647191,-0.049456496,-0.02921659,0.09056833,0.073849835,-0.010949858,-0.10141146,0.030319495,-0.015055982,-0.01765408,0.031428576,-0.05975752,0.027644642,-0.037397914,0.012391633,-0.096912876,0.05420644,0.0086509185,-0.0142724095,-0.013823696,0.034979776,-0.07512593,-0.004307802,0.088195965,0.0029469177,-0.05484829,0.001837562,0.0671329,0.038725775,-0.014716429,-0.060940802,-0.09565339,0.03568542,0.016524205,0.034587324,-0.054094743,-0.040241532,0.016484685,-0.043775477,0.11265858,-0.08953916 +3.1.22.5,"Preference for supercoiled DNA; little activity on linear double-stranded DNA. Inhibited by single-stranded DNA, ATP and AMP.",384,1.0,-0.041502867,-0.012515356,0.016927967,0.012961915,-0.08922325,-0.009222523,-0.081572205,0.035052165,-0.07365659,0.070163555,0.0869496,0.1565764,-0.06670697,0.05765614,-0.034933407,0.05636416,0.036855742,0.029014437,0.04695808,0.0027929584,0.13385868,-0.046579264,0.060891896,-0.030102069,0.03235842,0.06431794,-0.059890185,0.055804685,0.0030739696,-0.047825184,-0.015804905,0.020677421,-0.0062304465,-0.0041807764,0.04002044,0.0023660145,-0.022379326,0.09711319,0.039805792,-0.048006624,0.0678303,-0.015239435,-0.03351359,0.02673283,-0.038898278,-0.1000183,-0.0223314,-0.047537908,0.00090438675,0.055462047,0.053122308,-0.014339872,0.013920451,0.015871994,0.06894052,0.07848404,-0.14452271,0.035112426,0.020825358,0.014944581,0.0074170465,0.018814256,-0.0149802035,0.014399277,0.13658983,-0.02060181,0.0010224293,0.023917591,-0.020612264,-0.0029048123,0.082124695,-0.055470396,0.026259655,-0.012187344,0.04621548,-0.045971513,-0.032462586,-0.12356491,0.035382807,0.07972062,-0.041666403,-0.115670316,0.01923384,-0.023415867,-0.024601122,0.024082974,0.12306975,0.026327217,-0.015911138,0.044538848,0.028219834,-0.023864679,0.048610944,-0.043807626,-0.085829236,0.042986367,-0.03348017,0.06476354,-0.014468168,-0.05522491,0.13214968,-0.050183818,-0.06495433,0.0032240192,-0.0034740104,-0.040660568,-0.0011494587,-0.00835341,0.03706948,0.018734649,-0.0072811,0.05528444,0.0012626209,0.032377295,-0.15812378,0.0056090183,0.039912812,0.009524287,-0.051814415,-0.011186796,0.01258197,-0.023894453,0.04723699,0.027378276,-0.0045173606,0.0078078895,0.0028820422,-2.5594522e-33,-0.021866271,-0.00461734,0.0567729,-0.0037827147,-0.012990187,-0.037414704,-0.050992645,-0.0015724979,-0.06478186,0.044531226,0.03713912,-0.018563319,0.12248862,0.120996475,-0.023267357,0.017951822,-0.01907314,-0.059723634,0.062841706,-0.012751124,0.018556219,-0.018366829,0.077183545,0.028002955,-0.010894173,-0.1003117,-0.033352174,0.048949372,0.07834902,0.023916654,-0.030639382,-0.03787007,-0.019729272,0.06830346,0.02798754,0.0736416,-0.036473144,-0.048068006,0.034610454,0.07343796,-0.10567773,-0.010467442,0.029285278,-0.09361733,0.04208514,-0.06768729,-0.01617824,0.0796146,-0.07966193,0.02233712,0.007528167,-0.046784293,-0.0125019625,0.053537045,0.0105476985,0.030391382,-0.007447233,-0.035839904,-0.02676266,0.072445184,-0.013445734,0.03397157,-0.009899736,-0.017371597,-0.036861807,-0.029172612,-0.038518153,-0.0437518,-0.014005375,-0.025248656,-0.015406149,-0.028221717,0.08019105,-0.05860247,-0.004209931,0.056438096,0.006837135,0.027495544,0.006428802,0.05167692,-0.00452394,-0.02886474,0.016138831,-0.03650364,-0.07128739,-0.037281156,-0.051465243,-0.04582177,0.026311431,-0.011280845,0.09236538,-0.019959146,-0.05308902,-0.066704996,0.059274472,-1.5907796e-34,0.13399561,-0.032019123,0.095438905,-0.0296128,-0.010403948,-0.0007156578,0.023778724,-0.08657681,-0.010636359,-0.09931934,0.071570754,0.00954049,-0.03355488,-0.030367076,0.054875534,-0.01860654,-0.019041575,0.033625983,0.03249849,0.008909098,-0.018232977,0.06679388,0.015429228,0.12169517,0.07920972,-0.06328087,-0.05566401,0.017544204,0.037516512,0.01752362,-0.04915801,0.041504543,-0.012642103,-0.036056228,0.006590193,0.07698727,0.025335075,0.057192594,-0.012037757,-0.05274765,-0.034534145,0.09774476,-0.076303735,0.08466844,0.03464144,0.025670636,-0.022212598,0.037384775,-0.009313491,-0.051721077,0.01504472,0.0056741997,-0.04274415,-0.042242255,0.07622123,-0.051108204,-0.028040817,-0.0721309,0.022011466,0.0021456825,-0.0010188717,-0.045606744,-0.031196559,-0.057059463,0.035345364,-0.009438587,-0.026996518,0.044244178,-0.062157422,-0.041294467,0.018453786,0.021835245,0.017173469,-0.03348253,-0.039363235,0.047425225,-0.09945478,-0.054343335,-0.022034746,-0.0059175673,0.0053901467,0.025857175,-0.11259208,-0.045427296,0.11513847,0.024252024,-0.06326986,0.022617223,-0.042822022,-0.087440394,-0.06514646,-0.0047267135,-0.029412927,0.022020726,-0.012842338,-2.6064885e-08,0.032576453,-0.006708334,-0.02484825,-0.0589257,0.0073974277,0.045739863,-0.024689982,0.051800337,0.124893054,-0.024524562,0.0020856913,0.08195411,-0.0010795476,0.012012023,0.09034506,-0.029326461,-0.077958606,0.043058615,-0.051865738,-0.011341234,-0.09564699,-0.023009336,-0.16847868,0.016693419,-0.03245361,-0.009571117,0.12367506,0.005531704,-0.008394554,-0.059373632,0.025548467,-0.039325476,0.008295406,0.010978607,-0.017952114,0.026326863,0.05963684,0.062442735,-0.04576215,0.049358837,0.014092587,0.011101136,-0.017081168,0.022703672,-0.026524074,-0.051723413,0.024277484,0.03712594,-0.05314361,0.010465197,0.018471891,-0.03544301,-0.010789951,-0.05780714,-0.01356212,0.005106991,0.03104324,0.006351257,-0.056909043,0.031617463,0.048776373,-0.0255658,0.043952122,-0.05431526 +3.1.25.1,"Acts on a damaged strand, 5' from the damaged site. 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+3.1.26.2,Specific for O-methylated RNA.,384,1.0,0.024389746,-0.009535127,-0.05827879,0.0008034203,0.0011628355,0.018275317,-0.05619733,0.0042303796,0.005971968,-0.016627781,0.011445773,0.057402756,-0.06266613,-0.02948297,-0.01006102,0.1415345,-0.07115832,-0.0047752447,-0.0108922245,0.00941046,0.059807055,0.12161911,0.056658674,-0.07273072,-0.070072696,-0.0004939763,0.028204203,0.042846885,0.038838398,-0.052746985,-0.0018526459,0.056306824,0.085273296,0.010495052,0.000755399,0.0103069935,0.015074868,-0.06334213,-0.0035988577,0.091043875,0.09422956,0.053846955,-0.048389513,-0.015617983,-0.043589,-0.060481474,0.029126905,-0.054178268,-0.034679014,0.055012368,0.025580673,-0.0921425,-0.052936804,0.011541078,0.028891118,0.0376345,0.006494132,-0.03217147,-0.002923117,-0.005563283,-0.017131217,-0.02247549,0.016348412,0.002694251,0.08392354,-0.0078039328,0.07898196,-0.03985231,-0.039545678,-0.033408903,-0.0009632018,-0.01650821,-0.06438085,0.12136864,-0.02147593,0.041163426,0.08773705,-0.05620314,0.07467055,-0.032837387,-0.06447985,0.047381803,0.045208953,-0.0016215185,-0.009323309,0.09599537,-0.046927966,0.12764451,0.018338187,0.047084466,-0.029988896,-0.009833074,0.0006757592,-0.023962282,-0.0026304699,0.011775182,0.11720226,-0.011251155,0.019791836,-0.069014885,0.016139267,0.035226874,-0.10825755,0.026449788,0.019614205,-0.024712332,0.067072265,0.0018741083,-0.07554704,0.026632823,0.011958749,-0.024536176,0.08390403,-0.082816765,-0.058798954,-0.023611547,-0.011045744,0.02904486,0.020221885,-0.010848312,-0.03250744,-0.07050201,-0.004231201,0.030397147,-0.051423844,-0.02890703,-0.06694544,-4.2759434e-33,0.090856954,-0.019311335,0.034690697,-0.033070516,0.039343547,0.058198854,-0.003939158,-0.008785897,-0.0069726417,-0.09881638,-0.03890166,-0.07260053,-0.002400806,0.0017923823,-0.014204484,-0.019943887,-0.04091264,0.0040289364,-0.07831629,-0.10592191,0.027289337,0.07686875,-0.024931092,-0.0063588894,-0.03064101,0.0052375565,0.023437181,-0.065686606,0.05204029,-0.038130365,-0.009263073,-0.06705393,-0.03256291,-0.014308238,0.045968734,0.031604096,-0.06772873,0.02715621,0.047443822,0.09460213,0.041971985,0.018414827,0.0060523446,0.007981345,-0.0052887523,-0.0032680165,-0.086528696,-0.004708433,-0.053314794,-0.005240717,0.038825903,-0.001217825,-0.04830679,-0.013393526,-0.060925137,-0.02735104,-0.09449082,-0.03585432,-0.044524476,0.06262184,-0.016127229,-0.05634895,0.0615279,0.1052864,-0.03515469,-0.063120574,-0.10291047,-0.111689664,-0.013189235,0.06143563,0.050855465,-0.07174539,0.13180715,-0.037904594,-0.060459472,0.0040276754,-0.021971352,0.01183691,0.021234557,0.056138884,0.004798127,-0.027883224,-0.06706915,-0.035802174,-0.06784713,0.011570984,0.062014744,-0.043132327,0.0008476416,0.049371116,0.015766324,-0.050700642,-0.057819873,-0.09839952,0.0015997709,1.7704693e-33,-0.0014292381,-0.02117624,0.086916275,-0.051020626,-0.04943886,0.053819086,0.03724459,-0.048846774,-0.03760971,-0.03608026,0.03898897,0.08726503,0.036905125,-0.059248626,-0.0061439313,0.017810488,-0.055361904,0.10105343,-0.02620135,0.03581191,0.015155768,-0.028105324,-0.024768103,0.08999786,0.085729405,-0.01094695,-0.015982356,0.017194714,-0.020534057,0.0016912298,0.00041614615,0.027963655,-0.027131418,0.010270019,0.01844438,0.0088601895,0.009417548,-0.056474447,-0.0640818,0.024709748,-0.08847854,0.008461676,-0.044689402,0.102512,-0.017620042,0.060362335,-0.06612815,-0.016906144,0.058349047,0.0035878536,0.03149013,-0.020971838,0.037149332,0.043805245,0.031927843,-0.03316921,-0.009780642,-0.0026713165,0.0025462925,-0.022072442,-0.030624283,-0.0073156487,-0.009550628,-0.0027374534,-0.010691072,0.04761178,0.11426873,-0.022023547,-0.010627292,-0.07384584,0.02795883,-0.008906432,0.04094544,0.010474433,-0.0038434013,-0.063239366,-0.057819113,0.0038075892,-0.106934585,0.032102186,-0.08813569,0.023693189,-0.0015787927,0.047154278,0.006224666,0.0007137052,0.05646846,0.06627922,-0.04790316,0.0478024,-0.07262026,-0.005665478,-0.06870729,0.07641597,-0.00040966732,-1.4425058e-08,0.0014034266,-0.1126695,0.01396885,-0.042393412,-0.015877876,0.07074567,-0.04248814,0.04308846,0.07221184,0.03038464,0.069870986,-0.0024849062,0.000466655,-0.011719761,0.08697123,0.0025130543,-0.0093046455,0.016790222,0.017774759,-0.013339308,-0.08916951,0.07840732,-0.04940322,0.061485443,-0.052244242,0.051817566,0.02587208,0.10109434,0.06644346,-0.074847445,0.08588889,0.02888869,0.12865587,-0.05997415,-0.093311876,0.024320966,0.1417549,-0.013962421,-0.034939267,0.08212712,0.009332049,0.026676096,0.017574832,-0.019008625,0.025307922,-0.008967773,-0.008622621,0.11075946,0.02433239,-0.041948173,0.0023774498,0.027240682,-0.0014098467,-0.021437617,-0.10432892,0.011478989,-0.071080595,-0.020126572,0.00023359318,0.026535165,0.0009512026,-0.013039452,0.15991595,-0.045849975 +3.1.26.3,"This is an endoribonuclease that cleaves double-stranded RNA molecules [4]. The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site [5]. Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage [6]. RNase III is involved in both rRNA processing and mRNA processing and 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+3.1.26.4,Acts on RNA-DNA 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+3.1.26.6,Forms oligonucleotides with an average chain length of 10.,384,1.0,-0.03582456,-0.079390906,0.0005281347,-0.061472055,-0.049796853,-0.02795087,-0.029050173,0.13112356,-0.013168437,0.03448902,0.047551855,0.040347986,-0.116039164,0.04638195,-0.05769002,0.05458935,-0.14618008,0.043767467,0.021528065,-0.022886056,0.058841217,0.044423465,0.056541648,0.02036326,-0.05224106,-0.002212223,0.035730306,0.018384054,0.012701542,-0.028140739,-0.055359777,-0.09336112,0.079834476,-0.023033604,0.057899393,-0.061846808,-0.013703118,0.010319589,0.014111051,0.025467193,0.091527306,0.052837376,0.08674479,0.047161885,-0.062627114,-0.062287316,-0.061447375,0.034482367,-0.052330945,0.05258026,-0.004959415,-0.018300815,-0.085322276,0.04740152,0.052994374,-0.018942475,-0.122361004,-0.07018183,-0.019746935,0.029641984,0.024397159,0.0053081354,-0.02493582,-0.021795262,0.07675301,0.06147119,0.09829332,-0.0002572761,-0.012996988,0.075947374,0.032408018,0.032432854,-0.09131233,0.062939204,0.018312281,0.01529015,-0.013227184,-0.03246959,-0.006336646,0.029890398,-0.0965377,0.0071443073,0.016089477,-0.0038417333,-0.05081473,-0.012211583,0.060589083,0.0920988,-0.062400516,0.048574694,-0.03176176,-0.023395665,0.009353438,-0.12810586,-0.029711748,0.005821321,0.050851732,0.054594725,0.03662009,-0.03460738,0.091621235,0.015668439,-0.0071054436,-0.016854359,-0.040557873,0.06622742,0.05360109,0.003045533,-0.031019334,0.017597996,0.01168309,-0.01750297,0.034799617,-0.019883301,-0.07162951,-0.046365,-0.04946578,0.0010493066,0.027412863,0.1035798,0.053639274,-0.019829582,-0.029825877,0.06227186,-0.05171401,0.056969304,0.034084324,-1.8471794e-33,0.027399477,-0.0074760574,0.057538867,0.043193955,0.022058707,0.055574674,-0.023920074,0.022911673,-0.09901294,0.05523536,-0.048498537,-0.02001704,0.07242731,0.032740206,0.010758609,0.007717728,-0.0066046915,0.046830002,-0.0025873445,-0.07154015,-0.008346551,0.062844254,0.029484015,0.006469404,0.06656144,-0.042435203,-0.13078833,0.041800644,0.030357162,-0.020970952,0.06691656,-0.022311281,-0.11105296,0.046516534,0.072939284,-0.03145393,0.029542815,-0.03984242,0.09165756,0.0043715835,0.021200465,-0.013175694,0.0045902655,0.020941503,0.05075474,-0.005882587,0.04007339,-0.040867545,-0.05363558,0.018437555,-0.031035481,0.005041532,-0.006337951,0.009723886,0.02565846,-0.015625544,-0.017565848,-0.013709162,-0.039491136,0.090086095,0.05876349,0.09666348,-0.02484622,0.014304946,-0.034539547,0.0148819,-0.055456582,-0.041176192,0.03263419,0.043443784,0.070149526,-0.083856925,-0.048718967,-0.01181345,-0.024113875,-0.0027144356,-0.055389427,-0.09018133,-0.05489983,0.06474303,-0.017517997,-0.014468447,-0.054038547,0.00014500954,0.011440861,-0.029579611,-0.007564206,-0.060253724,-0.041298673,0.073117495,0.026969243,-0.09077877,0.0061568785,-0.06628149,0.024876157,-1.029335e-33,0.0032831458,-0.061770536,0.054944005,-0.037744857,-0.10570416,0.025307402,0.06510781,0.091551796,0.008406059,-0.007403586,0.07892785,0.056324296,0.035099167,-0.06317852,0.037835192,-0.003632841,-0.054211475,0.10772611,0.075956814,-0.0033057746,0.049286947,0.012488392,-0.04284049,0.06007422,0.049730092,0.03871468,-0.0132695,-0.0039458564,-0.0011847873,0.009893922,-0.09539048,0.0055807456,-0.016714653,0.030606056,-0.05021381,-0.0037328878,0.043964807,-0.0047899825,-0.020794813,-0.03156287,-0.046606693,0.054484073,0.050116926,-0.0020521195,0.043429192,0.041311044,-0.025953736,0.015922539,-0.04394946,-0.03285946,-0.019082718,0.04297868,-0.039774556,-0.022321349,-0.011771174,-0.019130798,-0.10233242,0.029538047,0.065226026,-0.017861078,-0.045226473,-0.070219845,0.011021232,-0.043065112,0.058747943,-0.021007534,0.0010700307,0.005158675,-0.049212825,-0.08377139,-0.013701336,0.036561526,0.05183676,-0.038467262,-0.014219215,-0.0093636345,-0.05297854,-0.057045244,0.013395495,-0.010195795,-0.0070214965,-0.04053447,0.010344938,-0.021579798,-0.0008362326,-0.09539792,0.1418756,0.05947391,0.013974182,0.07500663,0.07501499,0.027846182,0.050507974,-0.008923626,0.031132223,-1.8712818e-08,0.118202195,-0.0660917,0.029089663,-0.08918413,0.024994332,0.02449024,-0.0013377867,0.07438479,0.0159828,0.07290109,0.080309376,0.062254168,-0.033051644,0.080724865,0.03210513,-0.043901872,-0.07022206,-0.03267608,-0.017800061,0.014400964,-0.14634563,0.08136749,-0.08841429,0.025839426,-0.09424334,0.04840208,0.064792186,-0.020620674,-0.015835091,-0.005836844,0.07344789,0.0045501743,-0.019980222,-0.043119512,-0.091772184,-0.0119691705,-0.017475616,-0.00062643155,0.0036216273,-0.028207669,-0.029653765,-0.04846075,-0.023553941,-0.015787382,0.0061742165,-0.066378884,-0.0510103,0.08313689,-0.05950376,-0.027256364,-0.00063117186,-0.005897529,-0.038563464,-0.068713054,-0.023098605,-0.11177302,-0.00093238446,-0.020443609,-0.083957575,0.0086148875,0.021465467,-0.034285363,0.13036565,-0.043176997 +3.1.26.8,"Converts the 5S-rRNA precursor from Bacillus subtilis into 5S-rRNA, with 5'-phosphate and 3'-hydroxy 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+3.1.26.9,Forms oligonucleotides with chain lengths of 6 to 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poly(G).",384,0.99999994,0.0019975062,-0.102425486,0.024594028,0.012850619,-0.01999036,0.024701668,0.09540393,-0.06764022,-0.009205576,-0.031024883,-0.008495451,-0.043511216,-0.09003991,0.09041515,0.0128781665,0.06547162,-0.03087593,0.019537168,-0.05236384,0.055049416,0.03551496,-0.1203093,-0.0111992005,-0.020371426,0.00536077,-0.057763055,-0.0009505876,-0.05804037,0.048160657,-0.05336283,-0.040398505,0.05370987,0.03765053,0.014700182,0.005548806,0.115919545,-0.04277808,-0.076071486,-0.021198602,-0.00830178,0.089387976,0.014937466,0.07312319,0.05863511,0.01594167,0.03226716,-0.020822436,0.036712095,-0.051035464,0.07529126,-0.02976305,-0.010467653,0.0054350044,0.011326936,-0.07605193,0.06934981,-0.0291231,0.04002945,0.034439176,-0.012951798,-0.08299585,-0.009299591,0.050517235,0.09428287,0.059039623,-0.012114764,0.0697209,-0.052538913,-0.04635675,-0.03617803,-0.0055656536,0.0062601557,-0.060754005,0.048641354,0.0021092356,0.031313755,-0.026399508,-0.09893424,-0.019519527,-0.033979084,-0.010887791,0.012182454,0.03011851,0.06209059,0.051159102,0.044232395,-0.04359948,-0.032661416,-0.05691128,0.07672806,0.02919587,0.027107876,0.0076623126,0.015789162,0.0118376715,-0.028943282,0.03310708,-0.00025630544,-0.07287017,0.027117953,-0.024517016,0.0133619355,-0.038270667,-0.013642095,-0.048105683,0.038219523,-0.07628507,-0.032930247,-0.07711146,0.018579973,-0.013114494,-0.016602146,0.041549534,-0.029269688,-0.0713988,-0.0025546418,0.046961624,-0.039907467,-0.00033250838,-0.030496411,-0.044377185,-0.06662035,-0.00039903182,0.060676504,-0.0465626,-0.02833223,-0.09374408,-1.3152225e-33,0.026409887,-0.10598978,0.08225545,-0.08346516,-0.046757773,-0.02056935,0.038855057,-0.05792303,-0.12023968,-0.05085447,-0.051650167,0.00039691658,0.08512563,0.15679352,0.069722615,0.06267544,0.09584796,-0.026143016,0.0108666215,-0.065802924,0.0028336805,0.14558552,-0.09481122,-0.07273803,-0.03672559,0.019147322,-0.015247053,-0.013706707,-0.022993607,0.0015871191,-0.040147427,-0.020783212,-0.013987798,0.12230326,0.06914729,0.06571679,-0.02058116,-0.0377362,-0.020272035,-0.029848577,0.032565027,0.06669258,0.038965788,-0.10548414,0.06544761,-0.040053364,-0.0031131664,0.059540242,-0.12741393,0.06889748,0.10831949,0.04136422,0.032792207,-0.014582822,-0.040885653,0.029682405,-0.016465109,0.032712493,-0.040689565,0.10113141,0.008898765,0.009270712,-0.021449046,-0.03698145,-0.0677789,0.048254956,-0.08829753,-0.0022063085,0.020031612,0.052010685,-0.005223154,-0.005544951,0.028537974,0.045722373,0.057541553,-0.0046212333,-0.13387115,-0.027419802,-0.032108724,0.0040603154,-0.08112784,-0.04410941,0.004194076,-0.025477925,-0.12973687,-0.03387,0.07224631,-0.06760382,-0.014762852,0.04368248,0.05212311,-0.057663918,0.03929146,0.020343816,0.045067344,-2.2096469e-33,-0.06121283,-0.039081667,0.013883569,0.034134015,-0.016192013,-0.053523276,0.04131775,-0.083812304,-0.00015074537,0.0038941375,0.09271837,0.022232745,-0.011070301,0.03960575,0.0056305197,0.010909521,-0.00911002,0.10677248,-0.027139647,0.01290649,0.016287953,0.02474105,-0.009722626,0.02233182,0.048429728,0.010597641,-0.015237292,0.0035123655,0.010473418,0.0488778,-0.06416608,0.048961114,-0.12035958,0.056761574,0.062121175,-0.03566189,-0.0546178,-0.028197872,0.036655053,-0.030268155,-0.022063266,-0.0148975905,0.055787407,0.12672777,0.028407121,0.04963458,0.035518855,0.011335815,-0.051165782,-0.023774182,-0.055945296,-0.018484171,0.076697566,0.0065391627,0.03319407,0.08042016,0.119374804,-0.08340604,-0.090827875,-0.073843844,-0.002849639,-0.013803404,-0.017598107,0.0116318185,0.038785573,0.001937935,-0.011958396,0.012494207,-0.010771086,-0.095208816,0.06453847,0.0546874,0.018423984,-0.024563003,-0.0593815,-0.02247567,-0.0016906189,-0.03414947,0.006277982,-0.0043114275,-0.0044441735,-0.005050645,0.013088515,0.02489818,0.026606396,0.026010152,-0.017437467,0.0023000697,-0.00846835,0.05872619,-0.021570144,0.06844499,0.015244586,0.022968853,0.04340975,-2.6927859e-08,-0.00082712213,0.00588114,-0.005836286,-0.03536149,-0.03510606,0.05396915,-0.04859733,-0.05687744,-0.055458993,0.026895141,-0.028789323,0.028082449,-0.033341072,-0.007836884,0.10961714,-0.07858946,-0.03094483,-0.020910874,-0.031033002,-0.03130181,-0.13254806,-0.019039275,-0.07227952,0.04997863,-0.12530701,-0.057542715,0.022497926,-0.02329433,0.07167387,0.051232576,0.045133684,4.5014014e-05,-0.017563697,-0.030691437,-0.016459765,0.042474642,0.0079023745,-0.044828366,0.023920806,0.065778345,0.06038691,-0.043349434,-0.014829691,0.017161839,0.070876405,-0.017014269,-0.020040689,-0.049748834,-0.025028186,0.09024901,0.09715756,-0.024833601,-0.050036803,-0.005705077,0.033611085,0.001030863,-0.049573377,-0.029616065,0.049425237,-0.046854854,0.024405772,-0.008514403,0.04559144,0.033015385 +3.1.26.11,No cofactor requirements. An homologous enzyme to that found in Arabidopsis thaliana has been found in Methanococcus janaschii.,384,1.0,-0.090290986,-0.060811732,-0.117891245,-0.05583157,0.047789462,0.060386058,-0.15000583,-0.03364703,0.01483892,0.016513413,0.09127128,-0.11899188,-0.07915084,0.006053434,0.004991448,0.013309628,-0.047482617,0.02473329,-0.010372088,-0.07775541,0.06123197,0.09547323,-0.008618186,-0.037874863,0.004225203,-0.021250896,-0.05371889,-0.032238167,0.0027616145,-0.017532885,-0.065683134,0.06849966,0.04130179,-0.02800392,0.06425072,0.0770742,0.033494074,-0.10798186,0.1181144,0.030486587,0.0413938,0.03639299,0.05479764,-0.0022812507,-0.04587556,-0.0074370326,0.016800193,-0.003810207,0.030432427,-0.06612171,-0.078385524,-0.012683811,-0.031646367,0.00072904857,-0.0024621899,0.031632245,0.013852356,-0.014871214,0.01184879,0.022747945,0.036980137,-4.0251773e-05,0.04948536,-0.0028860492,0.02534959,-0.05108093,-0.026012547,-0.041497607,0.12058219,0.027938688,-0.03786418,-0.031812616,-0.06773801,0.013093197,-0.043259203,0.060508225,-0.030587979,-0.012199812,0.034375757,-0.041649956,0.014743191,0.038871728,0.056269385,0.027982447,0.01685149,-0.034077063,-0.0053582443,0.036645446,-0.0060623917,-0.02288416,0.02838725,-0.022039637,0.01779516,-0.062942654,-0.056365322,0.022600787,0.06078573,0.04070928,-0.017144777,-0.046505135,-0.017564274,0.0037940545,-0.012004402,0.0065207426,-0.0917506,-0.013996974,-0.029519295,0.032602962,0.044122554,0.038666766,0.045172654,0.023724651,0.010556138,-0.04258364,-0.009309417,-0.008388931,0.0057210685,-0.08660184,0.029632041,0.01394929,0.010859646,-0.052842326,0.06129748,-0.029277952,-0.011269392,0.062134672,-0.14089072,2.691497e-33,0.0814557,0.08753604,0.023648527,-0.059877813,-0.068737656,-0.06354831,-0.05802506,0.06699143,-0.040919255,-0.039081275,-0.055998545,-1.1379472e-05,-0.013460429,-0.029406061,-0.07163457,0.016335657,-0.025549132,-0.09615208,0.023284798,0.040039368,-0.03348883,0.046493053,-0.058867488,-0.007862946,-0.0064830678,0.0049038674,0.041819364,-0.07456541,0.01799072,0.0010855378,0.0014569951,-0.078466475,-0.0259091,0.089436695,0.07145051,-0.019808931,-0.06925308,-0.056749027,-0.050857138,-0.012249883,-0.0053358865,0.05901067,0.015753327,-0.048444953,0.100422144,0.027751122,-0.030913968,0.054056425,0.027126633,0.05711503,-0.0036283168,0.038389087,0.09099156,-0.004284888,-0.033693176,0.017767236,0.022480872,0.02062152,0.04096464,0.087221734,-0.09083972,0.030343162,-0.034608003,0.11106379,-0.032310337,0.047086522,-0.1134725,-0.068749025,0.045721393,0.12519068,-0.018514678,-0.031848498,-0.061832625,0.07413737,0.021962136,-0.041230638,0.033552483,0.0062497747,0.00019821849,0.0055160164,0.07788296,-0.019403454,0.030451162,-0.028121866,-0.07503502,-0.03053445,-0.053440366,0.018443491,-0.01939915,0.022693718,0.062338203,0.0060225837,0.019047357,0.04878027,0.048194055,-3.9946207e-33,0.10082689,-0.049396075,0.08759041,-0.09184338,-0.051208053,0.09459091,0.027066521,-0.13943516,0.08435612,0.0077364696,0.10714292,0.0141181005,0.03364363,-0.03470527,0.06263987,0.030234441,0.00903856,0.054133162,0.01733762,0.01977323,0.00661848,0.056201853,-0.031374097,-0.070789255,0.06509498,-0.018432904,-0.0069168094,0.049222685,-0.06429815,-0.04822134,-0.016019814,-0.044900864,-0.029570328,-0.060617108,-0.08415592,-0.035844423,-0.043648057,-0.0023818875,-0.015967794,-0.016548168,-0.0038717028,0.078804724,-0.027276557,0.1086458,0.048479952,-0.031904843,-0.105950624,0.019268662,-0.0002443491,-0.0034446663,-0.056030612,-0.03747947,-0.064979054,-0.0688043,-0.02231834,0.08355151,0.053303253,0.03149015,-0.00036081587,0.010144204,0.034093022,-0.04055733,0.020142583,0.031655487,0.07509888,0.020066474,0.033697847,0.06549905,-0.0032252234,0.047419894,0.014596731,0.06557897,0.007996859,0.009291302,-0.002844442,-0.003098196,-0.09865278,-0.018307213,-0.020513074,-0.00046712023,-0.0022965688,0.0077091567,0.016587563,0.012692896,0.047300436,-0.05270673,0.04988489,0.06301654,0.020735916,0.040426333,-0.042075418,-0.03371474,-0.0536743,0.057024233,0.040920936,-2.8954851e-08,-0.0012434267,-0.01436346,0.03483401,-0.07962275,-0.004199202,0.055043828,0.05024672,-0.054428216,0.05338527,0.029819224,-0.014281284,0.017704846,0.01126281,0.04915279,0.0060280384,-0.05751703,-0.036926284,-0.005057985,-0.051075682,0.08445123,-0.023089712,-0.021810098,-0.10266101,0.081391215,-0.063287735,-0.04298288,0.070443064,0.07494799,0.0044034263,-0.003573715,-0.04115526,0.024646977,0.0038983042,-0.111489385,-0.1050026,-0.022336228,0.010166536,-0.024819802,-0.046017017,-0.032193813,0.0364907,0.025395785,-0.051792238,-0.0010148181,0.04495732,-0.0264504,0.02621192,-0.046391755,-0.011127602,0.07554668,0.033251695,0.0007426817,-0.03626973,-0.02678786,-0.06793189,-0.07048727,0.046483878,0.014348725,-0.044087272,-0.05356625,0.04394434,-0.051414836,0.19926415,-0.013036387 +4.2.3.197,Isolated from the plant Zea mays (maize). The product is named in the reference using a different numbering scheme for eudesmane.,384,1.0,-0.0673392,0.0774063,-0.060574435,-0.02280271,0.10796879,-0.024792539,0.022382041,0.0054926313,0.008197193,0.0057735685,0.1590136,-0.07946702,-0.032673106,-0.06750771,-0.05373905,0.023796799,0.02415305,-0.0066231964,-0.005438483,-0.046529602,0.072087966,0.07963205,0.0279535,0.015185212,-0.053547747,0.015282952,-0.012838276,0.036902864,0.06155908,-0.09558895,-0.055527348,0.045111306,-0.031647477,-0.018069472,0.00404826,-0.027007386,-0.0051047206,-0.09965375,0.007985979,0.034348257,0.020771092,-0.0119497,-0.014250987,-0.08286084,-0.08220544,0.0672886,-0.065082,0.03492252,-0.034967765,-0.020011574,0.036775805,-0.023759484,-0.08302842,0.0028149572,-0.033340693,-0.017702708,0.010721806,-0.0030856433,-0.008911344,0.13490723,0.06349747,0.057343014,-0.07746673,-0.0052690217,-0.03836935,0.016273957,-0.019079998,-0.018201346,-0.0024183136,-0.076752186,0.030895907,-0.088405885,0.030997084,0.027872477,-0.06675711,0.054902483,0.026299065,0.006043168,0.012709644,0.003767758,-0.06487071,0.07322731,0.047865774,-0.020601084,-0.015045868,0.045063943,-0.029757705,0.065546185,0.097529784,-0.012644651,-0.010260597,-0.03409584,-0.028319584,0.06629459,-0.028345035,0.023287391,0.08064907,0.01728663,0.018550426,0.012520547,0.004048109,0.020873187,0.02412545,-0.07307852,-0.14101915,0.03108629,0.018740175,-0.0727637,0.0837322,0.07403422,-0.06059489,-0.042893708,-0.02881456,-0.051653143,-0.090073034,-0.038821593,0.049816065,-0.089563936,0.08370388,0.007372046,0.04053571,0.018686933,0.028440002,0.054852087,0.024813741,0.12151167,-0.05837333,-1.9525995e-33,-0.018133793,0.010693249,0.041184165,0.03242613,0.012238298,0.034553792,0.008231375,-0.012134711,-0.06478904,-0.100034766,-0.091327265,-0.069915116,-0.047460932,-0.00039496322,-0.0055783596,0.0025867117,0.037754513,-0.053422503,0.041577496,-0.007452382,-0.0051240893,0.06582271,-0.04135938,-0.014502889,0.028832782,0.03873846,-0.042043414,-0.077138916,0.040763598,0.03610169,0.11728032,-0.04478225,-0.038927685,-0.01703657,0.02131683,0.094773024,-0.06411238,-0.07015604,-0.061846156,0.06735926,0.057506774,0.053817376,0.07520048,0.0169382,0.0419955,-0.016096734,-0.04080721,0.0333399,0.122455426,-0.10115738,-0.036434315,0.02552354,-0.023561146,-0.055235565,-0.06719592,0.079489864,-0.008008989,0.014110565,-0.023645755,-0.007742098,-0.035904244,0.13587257,-0.006610425,0.05369455,0.0634236,0.031249251,-0.088710874,-0.0036314165,-0.03157642,0.039236795,-0.048713896,-0.060547944,0.1117498,0.004180678,0.03608781,-0.026052456,0.07049792,-0.017046085,-0.06988845,0.015816271,-0.038422298,0.0045847106,-0.025613578,-0.021780828,-0.049340546,0.020128798,-0.08952966,0.063512325,0.038731333,0.023305913,0.06216537,0.026562862,-0.057920497,-0.026844705,-0.10298256,-4.053434e-34,-0.029995592,0.04941353,0.038091462,-0.018660331,0.02347284,0.0009588534,-0.0898206,0.03890167,-0.017385777,0.005132139,0.0029218707,0.024601903,0.047265485,-0.019659339,0.025809322,0.08187209,0.01717653,0.11257603,0.009852604,0.04155406,-0.062235158,0.0469015,-0.030332863,-0.08787086,-0.0019846864,-0.04414489,0.04490876,-0.024409149,0.037729464,-0.0975339,-0.023971273,-0.08794116,-0.03359287,-0.06906332,-0.045233667,-0.014127258,-0.060038276,-0.080914035,0.0046601454,0.02694095,-0.06487721,0.031300787,0.04763324,0.028799836,0.002059303,0.040363237,0.0147461165,-0.026136216,-0.040733807,0.06459012,0.039671473,0.011893552,-0.074730456,-0.045325186,0.021295559,-0.027919656,0.03174299,0.078913234,-0.08946829,-0.010680521,0.10281469,0.037322037,-0.033014808,0.013825822,0.08522516,0.072916195,-0.10223627,0.017787103,-0.018511843,-0.03544582,0.026658697,0.021161672,-0.012968476,-0.03533905,-0.024167815,0.03331159,-0.045782372,-0.04643111,-0.045397326,-0.08015246,0.039002612,-0.035149295,0.0023348648,-0.0016683257,0.0166588,-0.039183654,0.008156002,0.040825427,0.060846746,0.025534002,0.0055569764,-0.01866892,-0.04843425,0.0667945,0.064261265,-2.4801965e-08,0.026876874,-0.084501125,-0.05566552,-0.029218711,-0.07891129,-0.03849046,0.008762308,-0.021163084,0.045581717,0.04411364,-0.0058484706,0.049090106,-0.037877444,0.056351572,0.08172547,-0.0149237495,0.0059032044,0.065010406,-0.006523582,0.069764175,-0.061377734,0.04281771,0.030418893,-0.027045758,-0.031724162,-0.038817704,0.04419414,0.029920034,0.040718637,-0.047027554,0.0026027374,0.06518147,-0.007338611,-0.0041634743,-0.036623135,0.03920726,-0.043201294,0.049970873,-0.026080543,-0.016563596,0.037580714,-0.048683863,0.04579997,0.016032228,-0.0013593833,0.044144325,0.0031183513,-0.011841901,0.029964238,-0.01041342,-0.04166574,-0.011201044,0.0796309,-0.0551015,-0.019936552,-0.07772435,0.013232505,-0.057119604,0.059461404,-0.09227853,-0.0007374151,0.004389994,0.11895028,0.10881008 +3.1.27.3,Formerly EC 2.7.7.26 and EC 3.1.4.8.,384,0.99999994,-0.07124561,-0.011324383,0.017447766,0.027170515,0.06040089,0.00028997727,-0.025651563,0.044083845,0.03278337,-0.022015557,0.0768714,-0.048290513,-0.058339193,-0.019525101,0.009833161,-0.07310647,-0.025492417,-0.06829548,0.05088443,-0.023215108,-0.047288906,0.0027089743,0.024520477,0.045789737,0.046808787,-0.023965912,-0.0065989536,0.019304927,-0.0074499818,-0.13328841,-0.031389292,-0.014156042,0.073992126,0.013244889,-0.0024422533,-0.052442927,0.027487664,-0.12003624,-0.06747598,0.046679314,-0.008124675,0.014803851,0.0700222,-0.016773157,-0.02679457,-0.044287253,0.02223982,-0.052000806,0.0038005034,0.0024618146,0.02884752,-0.07216107,0.0011295349,-0.008932504,0.060490515,0.03610083,-0.061940324,-0.011989046,0.011588985,0.06649262,0.067326255,0.012631785,-0.002970051,0.08983575,-0.08222739,-0.0005274744,0.049853,-0.0683239,0.003067209,-0.029029733,-0.11152196,-0.05383536,-0.02312221,-0.012245365,0.030939791,0.13237414,0.012181678,-0.009921815,0.00018148219,-0.10271948,-0.017784271,-0.07376011,-0.11438732,-0.018898275,0.0072116773,0.017987885,-0.025280448,-0.056120705,0.023636954,-0.04551151,0.038372118,-0.01832904,0.055880208,0.03957951,-0.036134664,0.034794137,0.02413311,0.09582629,0.021507509,0.046774674,0.003061523,0.097710416,-0.02521537,0.04066376,0.060901865,-0.0015375257,0.06497444,0.06680316,0.0025639883,-0.033669606,-0.005032272,-0.108578034,-0.03938588,-0.057461623,-0.050257638,0.02606812,-0.038471587,0.05575196,0.10776829,0.045489687,0.07173462,-0.045764342,0.017811632,0.0015051205,-0.067455016,0.052399885,-0.06774514,-1.6376627e-33,0.023403918,0.019674106,0.060120612,-0.0011921603,-0.018145744,0.008199938,-0.08765315,0.06585469,-0.061294783,-0.09105179,-0.05438496,0.02680182,0.0037893301,-0.06628429,0.045508612,-0.14271018,-0.037223198,0.07522853,-0.013717811,0.005357214,0.053504344,-0.021969406,-0.034474365,0.030849181,0.07351228,0.06842557,-0.0035144442,-0.0047039487,0.037493184,0.032596473,0.009937622,-0.054345198,-0.0059756404,0.02037177,-0.043259215,0.028040944,-0.06402795,-0.0275539,-0.024855342,0.02133876,0.0040344414,0.038175873,-0.0035680807,-0.07531252,0.005019739,-0.02147588,-0.05568951,0.077759914,0.15267004,0.0020044402,-0.023147196,-0.033519298,0.00711213,0.0038546147,0.10485591,-0.048708845,-0.019178577,0.03950547,0.037838522,0.04811028,0.013967188,0.113418885,-0.018266635,-0.047220208,-0.008757815,0.089524746,-0.002197247,-0.059771605,-0.07122913,-0.030007873,-0.08374263,0.004631726,0.077555135,0.017146066,0.056816168,-0.07389773,-0.11010449,-0.02107702,-0.04231869,0.025288794,-0.14689538,0.045219894,-0.03974516,0.043321494,-0.04815761,-0.017269922,-0.0047499132,0.024908697,0.039708618,0.01900213,-0.05164724,-0.002086045,-0.008283744,0.05335452,-0.069050424,9.537322e-34,0.0026607227,0.023581749,-0.04437773,0.042286243,-0.0062512225,0.022434222,0.052770156,0.15221232,-0.036048554,-0.037409704,0.11451315,-0.016985297,0.0842527,-0.04746554,0.066024385,0.0023209106,-0.06766747,-0.072139114,-0.019167943,0.020267474,0.037570395,-0.048502315,-0.036013115,0.068615705,0.057585653,-0.014663301,0.082100205,0.0076370887,-0.051384494,-0.0655655,-0.040217277,-0.034651894,-0.06457114,0.06988376,-0.036518972,0.00013822097,-0.018190896,-0.008013471,-0.03449966,-0.056777257,-0.009600826,0.03616831,0.024629595,0.0935029,0.048026543,0.059975732,0.09525805,0.05980355,0.021980368,-0.02112329,-0.049147382,-0.058201276,-0.021686003,0.0103699425,-0.055593267,0.04646313,-0.027314123,0.120025605,0.034956396,0.026874114,0.08054408,-0.010357588,0.052903958,0.006513067,-0.0142002255,0.009419842,-0.09669041,0.11199787,-0.040285278,-0.0015056315,0.02115917,-0.070285775,-0.0057800207,-0.050129976,-0.049630076,-0.0306888,-0.0069321757,-0.05443976,-0.011674716,-0.029091338,-0.031791236,0.08471429,0.009717527,0.07490712,0.002591845,0.01974696,0.055678815,-0.0039642365,0.01886866,-0.001316779,-0.06981603,0.014328911,-0.05877609,0.047963936,-0.03885833,-2.2166475e-08,0.06001298,0.03315125,0.04183383,0.00019007336,0.14736418,0.047087085,0.0009755958,0.0883836,0.03110392,0.045695946,0.037088186,-0.06343224,0.014289025,-0.034179322,0.06813804,0.028608177,-0.07074224,0.11457283,0.006962362,-0.02646138,0.0055682696,-0.012137692,0.022088852,-0.09037454,0.010461702,0.0068575675,0.016143907,0.03127404,-0.047259253,-0.04879064,0.0052262563,0.029167673,0.04152279,-0.024995161,0.0027346604,0.06853471,-0.09330664,0.0444701,-0.008954536,0.03298536,-0.049937334,-0.0097237695,-0.0030121787,0.015560206,0.045408737,0.040016968,0.018390626,0.05245933,-0.008487698,-0.081408925,-0.04839748,-0.034958247,-0.016050521,-0.009944642,0.013355313,-0.00241399,-0.049810484,-0.0644062,-0.023225568,0.0034418742,0.040495936,-0.038683705,-0.01872933,0.075309835 +4.2.3.196,"The enzyme, which has been characterized from maize, is involved in the biosynthesis of dolabralexins (type of antifungal phytoalexins).",384,1.0,-0.06769459,0.009554544,-0.058676027,0.04458632,0.05825852,0.03434831,-0.09459066,0.036206063,0.058332957,-0.05062544,0.058703326,-0.049302902,-0.04206384,-0.023130294,-0.08441741,0.06928414,-0.03561573,0.0873954,-0.013989985,-0.085157804,0.04240459,0.07005562,0.027464753,0.037600677,0.019946072,-0.06422825,-0.057301663,0.0042755273,0.0052143293,-0.01733943,-0.08958314,-0.003454207,0.0066328216,-0.03814012,-0.0550843,0.08157853,-0.022152662,-0.041184492,0.13752447,-0.06687675,0.035271157,-0.004867182,-0.018206254,-0.02334987,-0.044844776,-0.005882077,-0.0077525927,-0.012050502,0.00027160227,-0.03299841,-0.08685172,-0.014528548,-0.0688699,-0.015574029,0.01963816,-0.01136609,0.050164614,0.010448312,0.022903131,0.06408942,-0.0070788474,-0.0060731736,-0.043691985,0.013481932,-0.023041269,-0.0062395176,-0.06798155,-0.01541402,-0.02565343,-0.07593989,-0.033060923,-0.107041374,0.05087036,0.021823682,-0.011119015,0.06970369,-0.0068007233,0.085170895,0.016724618,-0.023177698,0.11460681,0.01102705,0.05071137,0.109316535,0.020326726,0.020724548,-0.033732425,0.08708922,0.056244634,-0.012560248,0.06353727,-0.02065429,-0.08039739,0.020222398,-0.0013602066,0.03620782,0.01001794,-0.00046624438,0.020591471,0.007697685,0.048273694,-0.037015516,-0.039849788,-0.03952035,-0.022349674,-0.00053950876,-0.0015688731,-0.017689014,0.042774934,-0.009755776,0.050832026,0.024978485,0.03960737,-0.014940068,-0.07781891,0.025865398,0.047522392,-0.016233133,-0.008042074,0.002417638,0.046359528,0.018670818,0.05843751,0.07312163,-0.0031852003,-0.044394724,-0.034210876,-1.6422231e-34,-0.009900128,0.027759658,-0.04843212,0.0152009195,0.052580617,-0.045892105,-0.038736228,-0.017268308,-0.036221325,-0.026308559,-0.061109904,-0.074123174,-0.05162036,0.044951048,-0.009281792,-0.025954366,0.020760784,-0.07546036,0.024686666,-0.031081347,-0.0075793136,-0.0029624982,-0.086382486,0.077286154,0.078393094,0.060832344,-0.11815025,-0.0036294525,0.03662493,-0.03465111,0.085817754,-0.0797421,-0.034336515,0.014739102,0.0056308093,0.03141934,-0.042586323,-0.045483667,-0.05045692,0.029597864,-0.057449874,0.05487493,-0.034324862,-0.041930288,0.13757911,0.019712863,-0.05684755,0.075353965,0.05882669,0.038851507,0.031336572,-0.06014682,0.06562824,0.00861722,-0.06424885,0.022924395,0.0015967868,0.008353841,0.004487057,0.077893525,-0.039604668,0.006844897,-0.025627187,0.021088002,-0.038233373,-0.006515683,-0.014858314,-0.04161834,0.023705648,0.06521047,-0.017576033,-0.025491085,-0.016562846,-0.0055302754,-0.010218686,-0.030553255,-0.058011267,0.015180362,-0.011371778,0.042956576,0.041367203,-0.020381516,0.011898018,-0.02065046,-0.06443473,0.048421457,-0.091793805,-0.034579135,0.046052232,0.028896112,0.06286121,-0.03863579,-0.12143331,0.04342168,0.018819487,-1.9380298e-33,0.035883818,-0.041559186,0.07598149,-0.035355825,-0.07748514,0.028151896,-0.054838326,0.040821888,0.03305187,-0.01537529,0.04141732,-0.016188854,-0.03694805,-0.019021422,-0.019926343,0.03529155,-0.062438954,0.10648497,0.024493415,0.06413623,-0.07840253,0.108072564,0.021069678,-0.021843031,0.10076335,0.03657088,0.011679309,0.10069524,0.046702962,-0.022311678,-0.045744926,-0.046744976,-0.00029339566,-0.060285516,0.03843834,0.04998895,-0.0058901273,0.07021568,0.008502279,0.04272177,-0.016413046,0.04842555,-0.036325123,-0.013419889,-0.042521916,0.09878391,-0.08363335,0.023792319,0.03208849,-0.058365837,0.032600634,0.041381866,-0.0012276312,-0.00987779,-0.025816623,-0.05852492,0.047942657,0.012739936,-0.040729925,-0.008143837,-0.026855934,-0.049602017,0.040099446,0.02641253,0.05493588,0.093634814,-0.06343632,0.039026663,0.06519021,-0.006252247,0.044864092,0.019283481,-0.033089828,0.019089669,-0.11482138,0.030217301,-0.048272897,-0.066251345,-0.02170546,0.03526964,0.049427513,0.025947958,0.022540877,-0.0021872506,-0.05797154,-0.052329,0.05457626,0.14818002,0.008525378,0.032164942,0.020628758,0.046244346,0.015575192,0.022630757,0.07685218,-3.310549e-08,0.02785308,-0.08797945,-0.01305982,-0.090334564,-0.021810878,0.016128583,0.026988478,0.017712522,0.017521368,0.036274698,-0.12426462,0.048157085,-0.053927504,-0.025607552,-0.0022530635,-0.015340788,-0.04647208,0.010168273,-0.0048994767,0.04351079,-0.020697763,0.022964645,-0.14121252,0.019610738,0.022882184,-0.13223523,-0.050681546,-0.009093478,0.020971922,0.04938187,-0.011591559,0.0375823,0.02361151,-0.045042645,-0.11196115,0.032730818,-0.078418925,-0.12843917,-0.0037658627,0.0110800695,0.018093381,-0.049031116,0.011377928,-0.050457697,-0.03002479,-0.02884327,0.01980093,0.00089206727,0.067434795,0.0135176685,0.048294593,-0.002919222,-0.032831565,-0.06409505,-0.08015894,-0.058290876,0.05356811,0.03189159,-0.022531532,-0.03319454,-0.054205958,-0.008962618,0.25924748,-0.05189422 +3.1.27.8,Also hydrolyses poly(U).,384,1.0,-0.023857972,-0.06693892,0.030901985,0.031723753,-0.01760185,-0.028324993,0.05466332,-0.024216823,-0.031628944,-0.06546672,-0.03215624,0.03579075,-0.08523485,0.046525955,-0.05010386,0.008932418,-0.028889373,0.048145026,-0.015162747,0.040984277,0.1101181,-0.049015462,-0.026376765,-0.016223812,0.03610051,0.057390798,0.10007397,-0.00988684,0.06985764,-0.09230883,0.014109555,0.008859903,0.033946585,-0.109794274,0.012765733,0.09705288,-0.020343123,-0.028561218,-0.039203368,3.627821e-05,0.071054354,-0.037549328,0.104287885,0.015658898,0.029104084,0.021225844,-0.029150993,0.009632129,0.04418841,0.07178401,0.005295363,-0.06091613,0.003057135,-0.0019438143,-0.05838448,0.01462116,-0.024316706,0.013794904,-0.01579776,0.027519071,-0.04657677,0.06467806,0.0052129366,0.08171483,0.028321248,0.008905875,0.007251961,0.015113602,-0.027864289,0.021242613,-0.009640802,0.021340132,-0.030757485,0.037234023,-0.054112844,0.030543083,0.003615984,-0.15169543,0.018399175,0.046888676,-0.039628595,0.035845358,0.020444864,0.040235862,0.069710985,0.10957989,0.019484699,-0.0194038,-0.08673682,0.00039418077,-0.012308754,0.042785026,0.027430512,-0.0017761379,-0.04141593,0.021769624,0.0660397,0.0039173807,-0.025255643,-0.014181628,-0.049218833,-0.027600497,-0.014924715,-0.100043274,-0.037892275,-0.0039956453,0.008460088,0.050907455,0.07604581,0.023242764,-0.049768243,0.0006427777,-0.01060244,-0.016658198,-0.056133777,-0.018016107,0.022222526,-0.019882198,-0.005376498,-0.0459479,-0.03517179,-0.081632145,0.0074133333,0.05946746,-0.008842275,-0.0765123,-0.02571958,-3.8612315e-33,0.029267453,-0.028901711,0.058322895,-0.0035879125,-0.022141704,0.014692603,-0.033764716,-0.08673223,-0.09587678,-0.04718229,-0.044096652,0.04750454,-0.016452078,0.12681064,0.056807112,-0.014736548,0.085327625,0.0011566894,0.034072056,-0.048432846,-0.008745053,0.09862835,-0.024640042,-0.0028002083,-0.045975883,-0.04361296,-0.0063363956,-0.030569077,0.05744316,-0.0028352914,-0.009503475,-0.010396875,-0.07625723,0.11515192,-0.06031562,0.08056074,-0.076540835,-0.054576296,0.026394138,0.10457517,0.036944315,0.008740086,0.05749324,-0.047508277,0.016632808,-0.031968582,-0.01789824,0.069801874,-0.05086187,-0.046795595,0.025086194,0.1279282,-0.0012105729,-0.040673945,-0.09143556,-0.042022068,0.045998503,-0.032111067,-0.041204855,0.09161315,-0.077347726,0.07705032,-0.025891863,-0.0037334836,-0.08816991,-0.01820693,-0.00060455874,0.007530844,0.0030257588,-0.023604345,-0.087019525,-0.016822169,0.104762755,0.047423277,0.01814408,-0.026599512,0.010801263,-0.03966824,0.044879653,0.040863186,-0.03767457,-0.049724847,-0.06152418,-0.006081283,-0.08254941,0.053570084,0.05614645,0.03208517,0.008590995,0.006077349,0.029368296,-0.13752377,0.023976797,-0.0041964217,-0.03610724,1.0546495e-33,0.011216905,-0.11318429,0.023457758,0.030345386,0.023974149,-0.029504163,0.090880305,0.028946402,0.004340076,-0.06412865,0.12548056,0.0006758923,0.010622527,-0.026445368,0.009862497,0.0859001,0.010511627,0.068328515,-0.03108584,-0.06897871,0.01270009,0.086611815,-0.0025991313,0.049698435,0.039591752,0.022788456,-0.023559421,-0.04057208,-0.0011045913,0.0992845,-0.05814556,-0.017880522,-0.11326033,-0.01708261,-0.040946014,-0.043192293,-0.040948573,-0.054590635,0.015913203,-0.008928548,-0.018661162,-0.040686343,0.08036651,0.10389632,0.026323335,0.10049139,-0.066744424,-0.01620745,-0.033831786,0.04659217,-0.010347818,0.005806304,-0.04969156,0.01844331,0.015585996,-0.0034274536,0.018877951,-0.023871252,-0.02784855,-0.018942833,-0.0523533,0.010735886,0.04467294,-0.04107681,-0.027642233,0.060235105,0.003708103,0.02969304,-0.031484354,-0.05466336,0.13715534,-0.011616382,0.007858731,0.064635545,0.017087037,-0.094284706,-0.027504578,-0.04159978,-0.044985525,-0.010733457,0.017853323,0.010989899,-0.03849338,-0.007608572,0.070024,-0.053760923,0.035099752,0.016957626,-0.0029901671,0.018492568,-0.0149733955,0.036606252,-0.047005694,0.06742369,0.061315857,-1.4742998e-08,-0.028426526,-0.06555685,0.05274054,-0.07896376,-0.03364673,0.049727514,0.03534037,0.054098606,0.020027468,-0.08345046,-0.024050824,0.032738794,-0.016082712,0.0021378223,0.08335878,-0.023704544,0.003165873,0.029234435,-0.032710962,-0.12687741,-0.10530208,0.0069998438,-0.07911193,0.060196653,-0.10025083,0.04130661,0.08082382,-0.0037101125,0.063005134,-0.019340226,0.007997323,0.003625037,-0.03409554,-0.00021129019,0.025002887,0.09900427,0.044322494,-0.035620045,-0.0687922,0.033445843,0.021807501,-0.06264184,0.0045326683,0.020399947,0.08948124,-0.032696456,-0.006988252,0.04796062,-0.01341488,0.047421943,0.08574373,-0.045658886,-0.035966188,-0.01963551,-0.014629641,0.015643163,-0.039550625,-0.06758403,0.027624639,-0.046638507,0.032047793,-0.01162455,0.20537217,0.013082142 +3.1.27.9,The enzyme catalyses the final stage in the maturation of tRNA 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+3.1.27.10,Also acts on bacterial 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+3.1.30.2,Hydrolyses double- or single-stranded substrate.,384,1.0,-0.026466459,-0.07416555,0.036718052,0.0021792,-0.0014938614,-0.051704284,-0.012107021,0.08182093,-0.053098075,-0.06739806,0.04211577,-0.004858131,-0.04998153,0.042248517,-0.036632907,0.01909544,-0.06307848,-0.038473867,0.05330749,0.022259686,0.12503597,-0.058737427,-0.06951351,0.011700205,0.009702617,0.01973281,0.005883763,0.038023956,0.015413588,-0.07665473,0.026810516,-0.008626938,-0.053496774,-0.016295588,0.04046708,0.06455452,0.02832453,-0.0048806965,-0.021064369,-0.044875428,0.05618609,-0.06685787,0.023196323,-0.03667201,-0.056753613,-0.07308173,0.04725204,-0.0052741724,0.043493487,-0.02807048,0.10281214,-0.063176215,-0.025641626,0.009931745,0.0033933555,0.01375214,-0.101757415,0.10007159,-0.054948304,0.033710845,0.028784547,0.06360439,-0.010368402,0.037111435,0.06332661,-0.038506724,-0.01980917,-0.0025383462,-0.006032176,0.00760448,-0.030995693,-0.07245411,0.027477058,-0.018504724,0.02275325,0.0041226405,-0.0061659957,-0.03200733,0.0881067,0.07949943,-0.074088156,-0.030928792,0.009519596,-0.0005987729,0.023359315,0.0324093,-0.01450162,-0.022133311,0.015439261,-0.03031171,-0.034080833,0.027934698,0.026751364,0.03792011,-0.072471745,0.013398074,-0.0032111267,0.029209973,-0.0001826164,0.0033281355,-0.0040036603,0.041670915,0.02319397,0.0060811043,-0.011891868,-0.03986709,0.01810506,0.06310932,0.058420382,-0.046230562,-0.017460022,0.050593592,0.037051436,0.047093466,-0.083980106,-0.018909406,-0.04632171,0.04045794,-0.010580355,-0.034569338,-0.06630355,-0.007125905,0.06254728,0.051488936,-0.07808595,-0.021471016,0.03064636,-4.915759e-33,-0.009751001,0.0088587785,0.015467253,-0.040102486,-0.085391164,-0.07150495,-0.06805314,0.02643155,-0.04926101,-0.0067816754,-0.015804462,0.03190419,-0.0045438334,0.17454648,0.03515726,-0.08933411,0.059439335,0.005737992,0.08834373,0.030216191,-0.0573614,0.056056514,-0.050476346,-0.012085415,0.059985567,-0.08643292,-0.008783947,-0.034276523,0.05109752,0.0008312915,-0.0119768875,0.016116343,-0.032038916,0.015631024,-0.0040023434,0.00068330957,-0.0464033,0.009991288,0.05463159,0.021429133,-0.038297415,-0.02199264,0.106109254,-0.07581232,0.031040343,-0.026562039,-0.088734545,0.054102127,-0.04953443,-0.07861073,0.0067980574,-0.007707576,0.019268358,0.040403433,0.027142303,0.013744798,0.014621044,-0.06233695,-0.0029501452,0.057311572,-0.045204867,0.1253692,-0.057319276,-0.016511036,-0.06550635,0.058389254,0.060342725,-0.0022827517,-0.04696367,-0.009048386,-0.096917704,0.030087335,0.10202478,-0.025750278,-0.022512492,-0.051616795,0.08604097,-0.040403407,0.060627136,0.08746283,0.0007965763,-0.04267178,-0.035296537,-0.021933414,-0.095857464,0.026720986,0.03629955,-0.039330795,0.020569019,0.046274524,0.07016469,-0.03223222,0.017840097,-0.08212872,-0.026919642,1.5506839e-33,0.072845794,-0.04531179,-0.011153479,-0.06857414,-0.018748146,0.018092211,0.058121026,-0.03830053,0.00036455953,-0.06934145,0.014569453,0.058817875,-0.051944494,0.015593636,-0.069882885,0.084490635,-0.036547985,0.006554247,0.014890832,-0.07137604,0.010927175,0.09700019,0.03636496,0.06497856,0.061454684,-0.06250537,0.034896918,0.048949026,-0.0012299897,0.058156,-0.034992345,-0.031259812,0.09558514,-0.034631975,0.012496292,0.06528224,-0.00030965405,-0.02884331,0.029158777,-0.05623303,0.013859739,0.010125208,-0.034538284,0.061738197,-0.016704516,0.1426757,-0.06861531,-0.02376397,0.010409042,-0.008850091,-0.01597122,0.0047588684,-0.08420568,-0.013620598,0.005835812,-0.03570311,-0.007949503,0.02392461,-0.029245079,-0.06759794,-0.003957579,-0.06484677,-0.0059670852,-0.110989355,-0.014562823,0.056129728,0.017190523,-0.031490065,-0.04416626,-0.0067401794,0.12571129,0.021070993,0.058033172,-0.011478186,-0.011109779,-0.009714304,-0.110426314,-0.08157102,-0.07240509,-0.03304333,0.026309382,0.05743204,-0.053119224,-0.061487854,0.09388658,-0.09511298,0.01398769,0.09112958,-0.00068625994,0.02865794,0.07100934,0.03111433,-0.03180573,0.11393484,0.04377475,-2.0680007e-08,0.04514146,-0.061122425,0.033911575,-0.0735337,-0.060897764,0.101136655,0.055872083,-0.02737339,0.06994538,-0.10730008,-0.08299011,0.044217627,-0.069786265,-0.014524248,0.08479293,0.04764423,-0.11030894,0.0020664232,-0.05453403,-0.007864428,-0.06153243,0.023536539,-0.086226456,0.01953503,-0.042414207,-0.026296875,0.05705844,0.058237243,-0.008538147,-0.0070117195,0.032795627,0.035103172,-0.007640378,0.038404007,0.012000574,0.016210563,-0.019005118,0.029702498,-0.025473606,-0.015991213,0.0066033755,-0.043693148,0.062495694,0.010590929,0.076480076,0.03502461,-0.035119012,0.089579985,-0.00021482627,0.0867435,0.013157716,0.0028410056,0.07257177,-0.019239454,-0.06468882,0.0032280693,-0.061322436,-0.020133724,-0.04728288,-0.0007624556,0.01956989,0.006422584,0.19734184,-0.037882872 +3.1.31.1,Hydrolyses double- or single-stranded substrate.,384,1.0,-0.026466459,-0.07416555,0.036718052,0.0021792,-0.0014938614,-0.051704284,-0.012107021,0.08182093,-0.053098075,-0.06739806,0.04211577,-0.004858131,-0.04998153,0.042248517,-0.036632907,0.01909544,-0.06307848,-0.038473867,0.05330749,0.022259686,0.12503597,-0.058737427,-0.06951351,0.011700205,0.009702617,0.01973281,0.005883763,0.038023956,0.015413588,-0.07665473,0.026810516,-0.008626938,-0.053496774,-0.016295588,0.04046708,0.06455452,0.02832453,-0.0048806965,-0.021064369,-0.044875428,0.05618609,-0.06685787,0.023196323,-0.03667201,-0.056753613,-0.07308173,0.04725204,-0.0052741724,0.043493487,-0.02807048,0.10281214,-0.063176215,-0.025641626,0.009931745,0.0033933555,0.01375214,-0.101757415,0.10007159,-0.054948304,0.033710845,0.028784547,0.06360439,-0.010368402,0.037111435,0.06332661,-0.038506724,-0.01980917,-0.0025383462,-0.006032176,0.00760448,-0.030995693,-0.07245411,0.027477058,-0.018504724,0.02275325,0.0041226405,-0.0061659957,-0.03200733,0.0881067,0.07949943,-0.074088156,-0.030928792,0.009519596,-0.0005987729,0.023359315,0.0324093,-0.01450162,-0.022133311,0.015439261,-0.03031171,-0.034080833,0.027934698,0.026751364,0.03792011,-0.072471745,0.013398074,-0.0032111267,0.029209973,-0.0001826164,0.0033281355,-0.0040036603,0.041670915,0.02319397,0.0060811043,-0.011891868,-0.03986709,0.01810506,0.06310932,0.058420382,-0.046230562,-0.017460022,0.050593592,0.037051436,0.047093466,-0.083980106,-0.018909406,-0.04632171,0.04045794,-0.010580355,-0.034569338,-0.06630355,-0.007125905,0.06254728,0.051488936,-0.07808595,-0.021471016,0.03064636,-4.915759e-33,-0.009751001,0.0088587785,0.015467253,-0.040102486,-0.085391164,-0.07150495,-0.06805314,0.02643155,-0.04926101,-0.0067816754,-0.015804462,0.03190419,-0.0045438334,0.17454648,0.03515726,-0.08933411,0.059439335,0.005737992,0.08834373,0.030216191,-0.0573614,0.056056514,-0.050476346,-0.012085415,0.059985567,-0.08643292,-0.008783947,-0.034276523,0.05109752,0.0008312915,-0.0119768875,0.016116343,-0.032038916,0.015631024,-0.0040023434,0.00068330957,-0.0464033,0.009991288,0.05463159,0.021429133,-0.038297415,-0.02199264,0.106109254,-0.07581232,0.031040343,-0.026562039,-0.088734545,0.054102127,-0.04953443,-0.07861073,0.0067980574,-0.007707576,0.019268358,0.040403433,0.027142303,0.013744798,0.014621044,-0.06233695,-0.0029501452,0.057311572,-0.045204867,0.1253692,-0.057319276,-0.016511036,-0.06550635,0.058389254,0.060342725,-0.0022827517,-0.04696367,-0.009048386,-0.096917704,0.030087335,0.10202478,-0.025750278,-0.022512492,-0.051616795,0.08604097,-0.040403407,0.060627136,0.08746283,0.0007965763,-0.04267178,-0.035296537,-0.021933414,-0.095857464,0.026720986,0.03629955,-0.039330795,0.020569019,0.046274524,0.07016469,-0.03223222,0.017840097,-0.08212872,-0.026919642,1.5506839e-33,0.072845794,-0.04531179,-0.011153479,-0.06857414,-0.018748146,0.018092211,0.058121026,-0.03830053,0.00036455953,-0.06934145,0.014569453,0.058817875,-0.051944494,0.015593636,-0.069882885,0.084490635,-0.036547985,0.006554247,0.014890832,-0.07137604,0.010927175,0.09700019,0.03636496,0.06497856,0.061454684,-0.06250537,0.034896918,0.048949026,-0.0012299897,0.058156,-0.034992345,-0.031259812,0.09558514,-0.034631975,0.012496292,0.06528224,-0.00030965405,-0.02884331,0.029158777,-0.05623303,0.013859739,0.010125208,-0.034538284,0.061738197,-0.016704516,0.1426757,-0.06861531,-0.02376397,0.010409042,-0.008850091,-0.01597122,0.0047588684,-0.08420568,-0.013620598,0.005835812,-0.03570311,-0.007949503,0.02392461,-0.029245079,-0.06759794,-0.003957579,-0.06484677,-0.0059670852,-0.110989355,-0.014562823,0.056129728,0.017190523,-0.031490065,-0.04416626,-0.0067401794,0.12571129,0.021070993,0.058033172,-0.011478186,-0.011109779,-0.009714304,-0.110426314,-0.08157102,-0.07240509,-0.03304333,0.026309382,0.05743204,-0.053119224,-0.061487854,0.09388658,-0.09511298,0.01398769,0.09112958,-0.00068625994,0.02865794,0.07100934,0.03111433,-0.03180573,0.11393484,0.04377475,-2.0680007e-08,0.04514146,-0.061122425,0.033911575,-0.0735337,-0.060897764,0.101136655,0.055872083,-0.02737339,0.06994538,-0.10730008,-0.08299011,0.044217627,-0.069786265,-0.014524248,0.08479293,0.04764423,-0.11030894,0.0020664232,-0.05453403,-0.007864428,-0.06153243,0.023536539,-0.086226456,0.01953503,-0.042414207,-0.026296875,0.05705844,0.058237243,-0.008538147,-0.0070117195,0.032795627,0.035103172,-0.007640378,0.038404007,0.012000574,0.016210563,-0.019005118,0.029702498,-0.025473606,-0.015991213,0.0066033755,-0.043693148,0.062495694,0.010590929,0.076480076,0.03502461,-0.035119012,0.089579985,-0.00021482627,0.0867435,0.013157716,0.0028410056,0.07257177,-0.019239454,-0.06468882,0.0032280693,-0.061322436,-0.020133724,-0.04728288,-0.0007624556,0.01956989,0.006422584,0.19734184,-0.037882872 +3.2.1.1,"Acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration. The term ""alpha"" relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolysed.",384,1.0,0.006731162,-0.10376782,-0.04080504,0.06327207,0.027551817,0.031338032,0.09850071,-0.051209312,0.045330655,0.057296865,0.07878725,0.05812673,-0.09764932,-0.013104917,-0.06207999,-0.004922988,-0.07699469,-0.00816819,-0.085946746,0.008609804,0.07252692,-0.12608166,-0.009472974,0.06567345,0.039440896,-0.02294155,-0.011459659,-0.048815493,0.052898236,-0.09506444,0.028776702,0.01907431,0.06625814,0.040804572,-0.03589772,0.09435299,-0.017028779,-0.10005912,-0.028513651,0.010707898,0.057637446,-0.06214136,0.018896753,0.04747425,-0.05012327,0.052089192,-0.06939144,-8.445508e-05,-0.055114966,0.022402354,-0.0030973153,-0.09017351,-0.10053978,0.048711605,-0.010534394,0.07567337,-0.046249066,-0.025917646,-0.02471927,0.08910767,0.030750196,0.02887891,-0.056393772,0.030472895,-0.0071755177,-0.0139524285,0.06721969,-0.020794557,-0.044549596,-0.024548694,-0.048685364,-0.00855316,-0.0021780527,-0.037546426,0.03565281,-0.018342253,0.0127413,-0.031528678,0.016769174,-0.0057722297,0.017583083,0.014884569,0.018959748,0.10079729,-0.060928654,-0.029517895,-0.0055887406,-0.080940455,0.008098118,0.038576987,-0.018989338,0.04971628,0.02064347,0.0010049421,0.0147438375,-0.017905273,0.067987844,-0.106459506,0.074545644,0.026563987,-0.024163391,0.032235418,0.009573418,-0.026970476,-0.06612556,-0.011256954,-0.019125449,-0.0064265975,-0.00045228738,0.13330783,-0.0061663133,-0.021878531,0.055004437,-0.0006012806,-0.106422395,0.03706165,-0.034080736,-0.0026573066,0.013899909,-0.05426526,0.025821071,0.0026531578,0.098146066,0.052369006,-0.07639676,0.07238117,-0.028207727,1.0848557e-33,0.07780414,-0.012214718,0.00046705647,-0.03442149,0.0032397625,0.017968161,-0.061433166,-0.06115823,-0.0075909276,-0.018142683,-0.05267475,-0.0034153587,-0.012103349,0.10057685,0.02192872,-0.058501486,0.016614866,0.039036725,-0.013429762,0.017622149,-0.06355691,0.120055296,-0.010748572,-0.04273885,0.023108032,-0.013745808,-0.14022861,-0.026616298,-0.008060943,0.007922263,0.081375524,0.08131207,-0.15669724,0.07931845,0.047864247,0.04068801,-0.061581798,-0.0068603973,0.013299844,0.010550294,-0.0009314425,0.0340676,0.0014112364,-0.06487559,0.052959297,-0.027494371,0.04013761,0.0055528353,-0.020242818,0.01076596,0.014333913,-0.0039241915,0.025530158,0.040301166,-0.009732907,0.032392733,-0.021242294,-0.0039635976,-0.0521851,0.081239335,0.011584256,0.08533088,0.01544979,-0.01434739,-0.013604369,0.017329821,-0.046155624,-0.024262477,0.014522838,-0.034853444,-0.012448499,-0.006100788,0.0632463,0.012443717,-0.020999363,-0.014492501,0.005123553,0.046042286,-0.048964288,-0.016760033,-0.045783993,-0.04784634,0.03900451,-0.020475613,-0.10881749,0.038633857,0.04217421,-0.03534311,-0.021674756,-0.031628467,-0.0015508297,-0.010239062,-0.027504131,0.018601617,0.019469447,-3.550475e-33,0.07864972,-0.12116212,-0.0033326831,0.008547953,-0.008934635,0.013873176,0.013998474,-0.058992513,0.04502058,0.03964672,0.016819103,0.08211372,-0.048347913,-0.07344673,0.0492129,-0.073495075,-0.0040268153,0.12568752,-0.06720107,0.02661631,-0.004673545,0.09162837,0.046226386,-0.009173321,0.09571064,-0.08494582,0.057296854,0.060181476,0.0080577005,0.00500438,0.0058632176,-0.03967834,-0.07245002,-0.069278434,-0.017511094,0.01701403,-0.030645125,0.0584111,-0.035808828,-0.025530502,0.0036424682,0.016266886,0.015874172,0.039167494,0.10729493,0.07995972,-0.06847538,0.04133505,-0.04498992,0.06535944,-0.0043173013,-0.03678297,0.047617055,0.03394167,0.015360946,0.052138973,0.0031686304,-0.0065075476,-0.068575494,-0.03532209,0.009630473,-0.0016100269,0.017121715,-0.033767954,0.020836305,-0.054056767,-0.012096883,-0.017039416,0.10908902,0.00086607755,0.0018313101,-0.015790317,-0.023759672,0.025750991,0.0341636,-0.032410044,-0.08465844,-0.10377038,-0.024565736,-0.088390715,-0.04680961,0.080147654,0.009621517,-0.019531202,0.0008738905,-0.055044603,0.059822746,0.06647042,0.018284092,0.052386727,0.008752701,0.010756329,0.019302243,0.06877393,0.03302408,-3.681262e-08,0.09714711,-0.045311265,-0.009396261,-0.012797034,0.039784793,0.013495489,-0.027352653,0.011051041,0.047211926,0.0034253178,-0.028208068,0.14028567,0.030551068,0.042069886,-0.016130049,-0.0375047,0.010619587,0.016006308,-0.085309714,0.025946142,-0.10269081,-0.029915376,-0.05974627,0.021558445,-0.084473446,-0.123867825,0.047563795,0.029069353,-0.10159114,-0.019701397,0.052952334,0.0715514,0.03298271,-0.06835107,-0.044368237,0.14570153,0.039627574,-0.025739914,0.041081514,-0.021838393,-0.031998843,-0.06241614,0.025668927,-0.0011665379,-0.04453687,0.020356474,-0.028785583,-0.015003692,0.045068,0.06559313,0.00010240077,0.047830917,-0.091394044,-0.03785215,-0.035833873,-0.021926327,-0.03732591,0.032240678,0.10818922,-0.05520362,0.045130055,-0.05119897,0.07015446,-0.08180827 +3.2.1.2,"Acts on starch, glycogen and related polysaccharides and oligosaccharides producing beta-maltose by an inversion. The term 'beta'' relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolysed.",384,1.0,-0.022129143,-0.11091717,-0.011138938,0.08479371,-0.036653854,0.059675697,0.0474955,-0.02867933,0.04166069,0.02030798,0.02362792,0.0700459,-0.09573072,-0.047810763,-0.099586666,0.019695213,-0.003503731,-0.027384268,-0.013371393,-0.01039744,0.09075074,-0.047371052,-0.02210986,0.04076106,0.06622737,-0.046894882,-0.022743538,-0.032497916,0.018795563,-0.06727214,0.014274503,0.021652525,0.07460777,0.04281865,0.0007471429,0.0709731,0.03361281,-0.10698061,0.011410435,-0.031769473,0.055101387,-0.061954744,-0.010464154,0.05052993,-0.0368086,0.010591164,-0.067116335,0.023478417,0.0006932179,-0.0068334397,-0.047539465,-0.11418381,-0.077316836,0.017424509,0.035559908,0.05864882,-0.042074885,-0.02693024,0.016239548,0.05459009,-0.0059498507,0.08733337,-0.046979766,0.03423655,0.006438373,-0.034100305,-0.00400841,-0.032230094,-0.06789031,0.0036170394,-0.065327555,-0.02926,-0.02984303,-0.029176759,0.041617583,-0.06996482,-0.009601786,-0.021411266,-0.00055978744,0.033177655,0.009456068,0.0010183146,0.050566744,0.012213594,-0.064830646,-0.051495243,0.023498487,-0.007985009,0.03374324,0.01882725,-0.035387628,-0.03147212,-0.0038842047,-0.009822976,0.044679604,-0.06754695,0.09058007,-0.13180843,0.12457706,0.008937363,-0.07459495,0.030259706,0.046462927,0.0020537553,-0.058843765,0.06753242,-0.012487929,0.046491135,0.024435766,0.052197937,0.008848414,0.01567581,0.08444891,-0.0011005286,-0.109313086,0.007043793,-0.054070745,-0.057334255,-0.008832292,-0.030000959,0.029346233,-0.010548078,0.049073197,0.047989983,-0.09429439,0.059295807,-0.052363396,2.6847937e-34,0.10572397,-0.012878185,0.051769223,-0.03814942,-0.014406112,0.010627155,-0.05835777,-0.049731415,0.02543449,0.024050899,-0.04331561,-0.04099889,0.021212066,0.103600316,0.034024216,0.024149578,-0.0051990254,0.009816253,0.07089185,0.04989188,-0.10786812,0.063904986,-0.051137853,-0.07973665,0.011782696,0.02354232,-0.10764637,0.01647898,-0.009223458,0.017868498,0.105794616,0.0458796,-0.051262885,0.046746403,0.046753086,0.09425452,-0.031079445,-0.025624119,0.027101446,0.00468618,0.04568903,0.0050558085,-0.019002696,-0.07551815,0.015684556,0.0068656863,0.016448908,-0.015419244,0.022029899,0.055714574,0.004442072,0.0030339223,-0.015527081,0.052536402,-0.00052797585,0.10393193,-0.03385494,-0.008574286,-0.032579407,0.07640955,-0.03078935,0.03530645,0.018205473,-0.06840383,-0.00013657099,0.008110275,-0.03714313,-0.008679351,-0.034254666,-0.02138116,-0.09130482,-0.002875221,0.03596192,0.015926912,-0.044742357,-0.024311822,-0.033742078,0.00592434,5.447794e-05,-0.04330339,-0.011425279,-0.05530879,0.020765599,-0.059354622,-0.061164677,0.062019125,0.0049429596,-0.009997042,-0.03142106,0.03893517,0.0049480614,0.015432596,-0.021309845,0.026729925,0.03852036,-3.641733e-33,0.08628854,-0.13669707,-0.044681806,-0.030308364,-0.0036222418,-0.027016325,0.026171863,-0.103946425,-0.011269371,0.052319,-0.027446728,0.077326596,-0.02401084,-0.0895657,0.0013297407,-0.017610656,-0.027418084,0.097185165,-0.06804271,0.02397676,-0.0040017315,0.11738863,0.07549887,-0.033412725,0.027795622,-0.023935586,0.050768055,0.0859824,0.022012861,0.04164713,0.023453325,-0.011917739,-0.012457718,-0.110258296,-0.03413836,0.022701517,-0.10693947,0.00030558967,0.045039456,0.00045551013,0.015069365,0.06701581,-0.025224017,0.0038473648,0.112269595,0.08361156,-0.03487607,0.008921305,-0.0039972067,-0.04172724,-0.022369511,-0.024451932,0.015808081,0.041518435,0.009449514,0.05447591,-0.020742645,0.008644487,-0.0017761309,-0.050315987,0.0046407944,0.00865517,0.05550835,-0.08280872,0.03421142,0.0027420162,-0.023363473,-0.04572751,0.104689114,0.053799227,-0.038006186,-0.050668918,-0.029226916,0.05595807,-0.0053741783,-0.058178667,-0.14836179,-0.059359454,-0.061417032,-0.048814613,-0.048424434,0.104481,0.0011511814,-0.00711646,-0.0013200203,-0.07931926,0.025154587,0.08920681,-0.010860029,0.028861802,-0.027178997,0.048490703,-0.006792505,0.04824234,0.089302965,-3.6196635e-08,0.056399133,-0.03661548,0.011165075,0.021004396,-0.025341453,0.018345866,0.05142235,-0.005255274,0.0043247123,-0.018727992,-0.07614339,0.13422781,-0.002150896,0.018047823,-0.007503099,0.0043503465,-0.041633725,-0.0013286804,-0.069933005,0.025111286,-0.104523174,0.013840948,0.0078101135,0.05970731,-0.08673779,-0.10338407,0.05172363,0.026961042,-0.06146643,-0.0035414365,0.06173759,0.14596663,-0.0005902847,-0.0834378,-0.05418236,0.061039507,0.010528315,-0.0041126288,0.071845986,-0.030519897,0.011327296,-0.0043196226,-0.0063253394,0.00094681024,-0.04323719,0.043418564,0.0017832418,0.0037593294,0.02528734,0.033253334,0.029525397,0.03032702,-0.12210341,-0.0134209795,-0.01716073,0.024259726,-0.06630019,0.010462297,0.07583396,-0.036369238,0.047137205,-0.039143607,0.11634605,-0.11471211 +3.2.1.3,"Most forms of the enzyme can rapidly hydrolyse 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyse 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides. This entry covers all such enzymes acting on polysaccharides more rapidly than on oligosaccharides. EC 3.2.1.20 alpha-glucosidase, from mammalian intestine, can catalyse similar reactions.",384,1.0,-0.004100292,-0.13437726,-0.09412366,0.0033639052,-0.005542139,-0.033990614,-0.055087544,-0.028116396,0.09091267,0.015553223,-0.018403705,0.08371032,-0.09885229,0.034861285,-0.069739625,-0.0522269,-0.0039768224,0.016361173,-0.1071261,-0.035186473,0.082739115,-0.082163274,-0.03775858,0.002111888,0.06615279,-0.06815065,0.08233083,-0.069503374,-0.010935208,-0.08488584,-0.0016348204,-0.10709404,0.086710095,0.036006913,0.049999017,0.071569994,-0.03866884,-0.05226415,0.03197269,-0.030096542,0.022205247,-0.043057505,0.04510083,-0.05018966,-0.09005859,-0.056381278,-0.08392575,-0.0060194037,0.041373678,0.037986692,0.020337189,-0.094571166,-0.09066928,-0.060269404,0.028956454,0.005800798,-0.053733483,-0.008764743,0.021939268,0.09032087,0.030428449,0.058988933,0.01133481,0.04754913,-0.059470877,-0.06883751,0.11101895,-0.031605203,-0.068129845,-0.013852465,-0.061529458,0.03700692,-0.042634796,-0.036805034,0.029744042,-0.01583984,-0.058928642,-0.023483377,0.023834312,-0.010769379,0.03364603,0.007951499,0.042402264,0.07076415,-0.0105668735,-0.005655889,-0.015270337,0.01823081,0.06412274,0.001825777,0.025210401,-0.024128735,0.0074993856,-0.008168541,0.0016337162,0.014996609,0.022354681,-0.012566305,0.0064616078,-0.06209052,-0.04642751,0.039219856,0.032084014,-0.035166826,-0.011375567,0.088099636,-0.01284072,0.10049364,0.06398289,0.060094886,-0.038448926,0.024897188,0.054426353,0.04442179,-0.06659016,0.04378037,0.044642635,-0.043428253,-0.024547288,-0.020376088,0.024593376,-0.023393752,0.100699455,0.038364757,-0.062487286,0.019133583,0.046625074,2.3418112e-33,0.021216732,0.005034552,0.0031515677,-0.018807447,-0.00660042,-0.0054263007,-0.0013677005,-0.0063254177,-0.036417484,0.014578796,-0.059071466,-0.043635353,0.036693826,0.13342436,-0.0017335713,0.062344335,0.044616643,-0.04040418,-0.0067181517,0.045488264,0.024513958,0.036946867,0.018131783,-0.0074132276,0.079009905,0.03877051,-0.0649948,0.07175538,0.07115331,-0.016662674,0.0046348143,-0.056334972,-0.10752162,0.10021676,0.015627509,0.055656992,-0.043830596,-0.027276918,0.022157336,0.030491631,0.021320902,0.004865491,0.009171934,-0.11026281,0.0540805,0.016182588,0.017578106,0.06889344,-0.030982628,0.1122034,0.051056203,0.03302814,0.008495176,0.05392176,-0.025551785,0.01896443,0.023587788,0.0040863818,0.019029228,0.10660136,-0.018496037,0.05828175,0.013102005,-0.025845446,-0.04279096,0.025792766,-0.05148434,0.008674057,-0.022401318,0.074606806,-0.09251385,-0.024855062,-0.05651059,-0.032746147,0.0313059,-0.11189146,-0.0032210562,0.02500505,0.015771205,-0.030249719,0.03548352,0.034854855,0.06950729,0.07642015,-0.06664181,0.060741346,-0.023307804,-0.034935784,-0.02549175,0.06514274,0.012332935,-0.061096393,-0.07458494,0.06303143,0.050353393,-4.428382e-33,0.13513866,-0.13409905,0.05961643,-0.06170646,-0.035653457,0.014538718,0.026131386,-0.0069912747,0.005911562,-0.06281707,0.043399334,0.036420457,-0.012911049,-0.05391411,0.004606612,-0.04697371,-0.04151865,0.09867324,-0.00013853154,0.0036690137,-0.026449794,0.049052346,0.012619092,-0.0304302,0.11815251,-0.037244312,0.010026058,0.0360201,-0.030421525,0.029489053,-0.016697817,0.011681238,-0.009520144,-0.017359799,-0.018984905,0.021648023,-0.060178004,-0.055858392,0.016063822,-0.033201955,-0.04003872,0.07111925,0.055941258,0.004057507,0.037740573,0.07782096,-0.07326068,-0.0019942059,-0.038201936,0.018759923,0.016272524,0.013472422,-0.002448748,0.081408605,0.05790291,0.020011388,0.061518203,-0.040766176,-0.039090484,-0.077556975,-0.072347775,0.022046067,0.0503927,-0.02558803,0.08431614,0.01872341,-0.05917941,0.05392023,0.00038132718,0.024718001,0.074209385,-0.069096155,-0.066255,0.03433081,0.037856158,-0.08924717,-0.08329689,-0.0016602156,0.005519918,9.4648894e-05,-0.012488567,0.048539527,-0.00027526118,-0.068426944,0.015098353,-0.062330168,0.063846834,0.11335079,0.007696069,0.074565254,-0.004678383,-0.002816847,0.008128067,0.032481838,0.10565673,-4.143075e-08,0.011627582,-0.03888463,-0.061839823,-0.077281296,-0.008464513,0.030407293,-0.046167634,0.010613569,-0.039521743,-0.009719311,-0.002894497,0.104898244,0.0136528965,0.053652257,-0.058897678,-0.0065203975,-0.047976855,-0.069067575,0.011437026,0.014913804,-0.10215441,0.018104073,-0.12140879,-0.019414308,0.014958519,-0.07508166,-0.0044381157,0.05212323,-0.07141316,0.042760123,-0.028375382,0.010603087,-0.01479474,-0.08254473,-0.003567734,0.05550053,0.003075069,-0.02355065,0.036114328,-0.037983287,0.016812295,-0.040343396,-0.01224857,-0.046631966,-0.0015260325,0.011829863,-0.027352141,-0.01502344,-0.007324766,0.03913306,-0.014889754,-0.03222129,-0.044227693,-0.06569391,-0.0040200925,-0.024929969,-0.049757164,-0.1013954,0.019716399,-0.045524523,0.04292098,-0.027404564,0.16070154,-0.030309279 +3.2.1.4,"Will also hydrolyse 1,4-linkages in beta-D-glucans also containing 1,3-linkages.",384,0.99999994,-0.042667195,-0.1206215,0.02405833,0.000883149,-0.014754371,-0.045498937,-0.013441195,0.0041190363,0.027208101,-0.019862587,0.01847107,0.06582333,-0.03286793,0.02368238,-0.08384534,0.03127934,-0.05812896,0.06389104,-0.109382585,0.0018327625,0.08469947,-0.02060413,0.012276771,0.003354219,0.03719174,-0.037214786,0.01806634,-0.018959146,0.047734294,-0.1035371,-0.033494573,-0.03964515,-0.04520632,-0.0027203753,0.08319258,0.04897381,-0.0019585302,-0.04441077,-0.006681061,0.053456765,0.1007909,-0.032953244,0.05369745,-0.009917242,-0.020961689,0.017105453,-0.086606465,0.04916262,0.063958004,0.02251857,0.029759744,-0.06748928,-0.076664194,0.054681506,0.034050625,0.015789002,-0.123719886,0.010937176,0.041804314,0.12102654,0.051951364,0.056702685,-0.04879092,-0.03459662,0.048760757,-0.02062742,-0.018696828,-0.01578087,-0.08039684,0.032106455,-0.0092916405,-0.03017489,0.036773775,0.023856172,-0.025026368,0.053343143,-0.023604732,-0.02282976,0.00856798,-0.044970997,-0.003574307,0.05876447,0.12010434,0.020479254,-0.04752135,0.0056423363,-0.058405668,0.0028265396,-0.038343962,0.0044074813,0.027002964,-0.067577556,0.029749919,0.007842644,0.04037391,0.037336227,0.061694656,-0.050277095,0.036914576,-0.039309114,-0.049628727,0.020723967,0.08166468,-0.03517306,-0.043490656,0.030833526,-0.042769477,0.12476487,0.05165118,-0.021948855,-0.040621314,-0.03672614,0.059370253,0.035297774,-0.103574485,0.005706754,0.02732212,-0.037411295,0.011525225,-0.049500484,0.02257393,-0.011291743,0.106436834,0.010704482,-0.08625319,0.021830864,-0.016641026,-2.0438554e-33,0.086814456,-0.027960278,0.005891653,-0.02254847,-0.062537275,0.010464973,-0.13900872,-0.034036387,-0.0009802043,-0.015094501,-0.14992227,0.00030367108,-0.006473412,0.11790819,-0.052056093,0.06537972,-0.0034541218,-0.03504321,0.010963571,-0.04451728,-0.02868549,0.033530228,-0.05024745,-0.009481792,0.06587224,-0.020495245,-0.017128363,0.003599587,0.081797965,-0.015014506,-0.024169257,-0.010809363,-0.04854962,0.0487533,-0.011814021,0.12259253,-0.02913708,-0.043365635,-0.001820257,0.038684793,0.062296532,-0.038232435,0.031265132,-0.07327641,0.050884444,-0.0024814268,0.039308436,-0.04847742,-0.08340729,0.027458018,0.0744195,0.0897295,-0.004834807,0.0065147365,-0.04383502,-0.012288305,-0.029767608,0.011655239,0.0128207235,0.10090534,-0.028853491,0.065889396,0.01016356,-0.023571072,-0.018570164,0.04977258,-0.08865569,-0.0020256673,-0.04236738,0.020223686,-0.07990023,-0.0014831291,0.09928934,-0.0071765925,-0.014399636,-0.045615498,0.017989652,-0.0005703258,0.030610764,0.021673009,-0.02910371,-0.011897266,0.012748045,0.07798821,-0.027280191,0.047303896,0.025488488,-0.09105716,-0.009608119,0.018567026,0.04152616,0.018185588,-0.06583153,0.007886027,-0.014620023,-1.16374685e-33,0.04709501,-0.038708463,0.036544215,-0.0059026675,-0.010160667,0.042634465,0.045741726,-0.046395253,0.03791914,-0.0069929804,0.11028469,0.07167241,-0.09100079,-0.072597936,0.0018419191,0.018875057,-0.059261486,0.030889526,-0.027112462,0.026291141,0.019242922,0.06796521,0.03859188,0.035870966,0.056147043,-0.03499666,0.084094256,-0.03841854,0.033392847,0.09518078,0.060025495,0.003024552,0.0057239137,-0.04970396,-0.0294115,0.00956119,-0.041189637,-0.008964424,0.0430567,-0.019705981,0.0590977,-0.031188902,0.02787277,0.00012178315,0.07359714,0.083661005,-0.0011271582,-0.01805889,-0.038409922,-0.0033773198,0.007224593,-0.002448626,-0.046860714,-0.011102028,0.038554903,0.010573345,0.019234791,0.052195843,-0.07376346,-0.035810295,-0.09521373,-0.026166154,0.056850012,-0.07543279,0.098995574,0.008254816,-0.016961386,-0.002670649,0.007482548,0.07294091,0.054463543,-0.054133814,0.041250713,-0.016663147,0.05334358,-0.070607916,-0.10991451,-0.06728823,-0.023699073,-0.04750198,-0.04639593,0.10888306,0.01555904,-0.034053933,0.06447913,-0.038277667,0.03567465,0.14108299,0.020969069,0.08017835,-0.011161053,-0.018346295,-0.0031119091,0.062451366,0.0072222822,-2.4553513e-08,0.07703262,0.014694767,-0.04124624,-0.079349354,-0.054202378,0.0356779,-0.0047940724,0.14553642,-0.01961216,0.019266987,-0.01908065,0.09243767,-0.069474414,0.002513199,0.0034140425,0.008355804,-0.05801741,-0.04960612,-0.039330877,-0.05912872,-0.10272027,0.015798086,-0.040595643,0.119449824,-0.069740444,-0.072177276,0.052437294,0.04206602,-0.017439442,0.0070977206,0.074128605,0.038925447,-0.088649996,-0.07939376,-0.024439003,0.02992362,-0.05526053,0.03995433,0.021909475,0.033881165,-0.008761802,-0.05640781,-0.0042035324,0.037231427,0.00080355484,-0.054041598,-0.0589273,0.015837146,-0.034116738,-0.010689174,-0.007906175,0.009168207,-0.07078769,-0.07553796,-0.07815079,-0.010197002,-0.013740848,-0.039817687,-0.0056958725,-0.08351981,-0.032988846,-0.021083897,0.10151959,-0.0033029797 +3.2.1.6,"Substrates include laminarin, lichenin and cereal D-glucans; different from EC 3.2.1.52 beta-N-acetylhexosaminidase.",384,1.0,-0.069852136,-0.14325443,-0.0438027,-0.04780796,0.06985762,0.057366554,-0.048249353,-0.035139687,0.028724752,0.012230555,0.06590536,-0.021590056,-0.12631942,-0.014626089,-0.074398495,0.0003301099,0.04454187,0.020057866,-0.006461209,0.014624381,0.06336963,0.02525549,0.027983112,0.0022766741,-0.0072077624,-0.008519596,-0.0012665128,-0.02238068,0.030491965,-0.09702756,0.014252708,0.019084804,0.048242785,-0.034001164,0.038470462,-0.0069750138,-0.0313118,-0.13032688,-0.005922194,0.04241706,0.06679197,-0.051310953,-0.01943131,-0.019097969,-0.014184081,-0.0726068,-0.042395215,0.04002043,0.051411476,0.0041537033,0.05447598,-0.060254585,-0.03857914,-0.0036182518,0.0046957848,0.028486622,-0.04640567,-0.002264622,0.007131689,0.08165778,0.029527526,0.0677943,-0.059882563,-0.0058626197,-0.039823648,-0.010443634,0.0153442295,-0.08478248,-0.039045382,0.065789096,-0.06559636,-0.0638379,0.0070871315,0.05163211,0.059012316,0.021770447,0.029071813,-0.12914671,0.0074196765,-0.014050903,-0.0064010336,0.050635673,0.06689824,0.11034183,-0.058332838,-0.04985534,0.013545299,0.0021464217,-0.02195924,-0.019131811,0.03679587,-0.031560488,0.011389519,-0.001345154,-0.024971332,0.03132721,0.086807735,0.023928998,0.06942196,0.021388954,-0.027927404,0.0075662937,0.019473296,-0.069426574,-0.057301924,0.04912475,-0.029432181,0.032377854,0.05981055,-0.004076181,-0.0023569851,0.00602089,-0.017494822,-0.0302909,-0.08701225,-0.07341098,0.06051288,-0.13488103,0.05680599,0.010629391,0.00017808093,-0.028720833,0.081439786,0.10236582,-0.017887656,0.04030986,-0.022521393,1.1432539e-33,0.019663375,-0.06127802,0.034809433,-0.03459064,-0.010100353,0.015059665,-0.052514736,-0.083268665,0.035714574,-0.038581472,-0.08044803,0.021026397,-0.047264475,0.11864274,0.04135811,0.0839577,-0.055757076,-0.04692148,0.05033268,0.048369884,-0.0139428945,0.009739304,-0.059860785,-0.028997712,0.09656152,-0.018794563,-0.00976979,0.025682814,0.02083824,-0.011417295,0.08263395,-0.02773094,-0.011921118,0.045222834,-0.055318538,0.12159806,0.017399162,-0.04106655,-0.022539765,-0.0052890223,0.07119138,0.041187607,0.049151048,-0.05471681,0.020103473,-0.003491072,-0.0002246668,-0.034644134,-0.022891467,0.020184131,0.08716509,-0.015423302,0.05982484,0.0006067714,0.044769786,0.012001773,-0.08635964,-0.001893603,0.0063590733,0.08169893,0.016962204,0.060226597,0.009358641,0.02717542,0.020343984,0.04025993,-0.07196278,-0.025870824,-0.020893598,-0.06626338,-0.03863965,-0.030180251,0.099829815,0.011639354,0.017159926,-0.03668398,-0.046761602,0.063143,0.021439482,0.01539263,0.024656536,-0.01368266,-5.0358794e-05,-0.024725925,-0.1403804,0.067848675,-0.031513467,-0.005503349,0.08075563,0.07647367,-0.006556843,-0.033275176,-0.01983347,0.07892578,-0.070410654,-3.1461967e-33,0.01852672,-0.08736881,0.0029492998,0.035465293,-0.05843233,0.06631694,0.012808301,0.0061326004,-0.0016245802,0.013318313,0.08229629,0.047050957,-0.05110927,-0.041953854,0.015127503,0.014451448,-0.06014919,0.034866516,-0.002074842,0.004527138,-0.040527746,0.039591305,0.056308955,0.05658422,0.064208575,-0.041404653,0.085091464,0.0022581993,-0.008826415,-0.016380094,-0.070942484,-0.0154791735,-0.007039998,-0.009672972,-0.041535977,-0.0026441643,-0.04321939,-0.007471952,-0.04521097,-0.024965096,-0.006004927,0.03884116,0.019744912,0.025097916,0.018445475,0.10548695,-0.02073262,-0.030593738,0.047247276,-0.034594942,-0.011708227,-0.01623302,-0.019886903,0.013384362,0.021497326,0.06203917,0.054028545,0.045072127,0.06607826,0.018054714,-0.04255319,0.05021285,-0.01891953,-0.102587506,0.12080866,0.08211819,-0.093155876,0.08833477,0.011125039,0.029150156,0.06583188,-0.01828593,0.041780405,-0.013657282,-0.02943702,-0.04866193,-0.062283866,-0.008552793,-0.027164746,-0.024116006,0.03628174,0.005322853,-0.047324143,0.06948566,-0.028519198,0.03788025,0.04627689,0.028412165,-0.06181019,0.032141432,0.0056820507,-0.0005471891,-0.10627301,0.03652257,0.029886346,-3.4048185e-08,0.09472743,-0.0067373966,-0.015732314,-0.1029505,-0.038405687,-0.014568816,0.08337471,0.058619063,0.053187758,0.02842255,-0.0596621,0.12630187,0.00016516309,0.057960313,0.028046405,0.007658786,-0.058046777,0.007049883,-0.0015054293,-0.033582415,-0.12643953,0.05475496,-0.035061415,0.025227046,-0.08340098,-0.11805386,0.053884532,0.07150019,0.07098698,0.00841993,-0.06147858,0.070998296,-0.08398023,-0.06604828,0.024080418,0.01295425,-0.09202181,-0.08368079,0.058111954,0.06856928,-0.058358632,-0.013579374,0.042377766,-0.044288937,-0.017484723,-0.075371325,0.0119307265,0.03225605,-0.0067142276,-0.0048072175,0.00027763398,-0.053724635,-0.043854695,-0.08094333,-0.08331407,-0.021818599,-0.020269943,-0.10760898,0.040173765,0.0043855235,0.001022647,-0.04875609,0.10669883,0.045919564 +3.2.1.10,"This enzyme, like EC 3.2.1.33 (amylo-alpha-1,6-glucosidase), can release an alpha-1->6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41 (pullulanase), EC 3.2.1.142 (limit dextrinase), and EC 3.2.1.68 (isoamylase) is maltose. It also hydrolyses isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin. The enzyme from intestinal mucosa is a single polypeptide chain that also catalyses the reaction of EC 3.2.1.48 (sucrose alpha-glucosidase). Differs from EC 3.2.1.33 (amylo-alpha-1,6-glucosidase) in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4.",384,1.0,-0.018852856,-0.11109941,-0.04141016,0.0013587464,0.024869544,-0.013171883,-0.033943553,0.034152016,0.07236517,-0.0330882,0.012814964,0.04808276,-0.08434464,0.024475278,-0.038547922,0.005668004,-0.016119882,-0.011478344,-0.027349418,-0.01836996,0.17299193,-0.0207565,0.018009298,0.051374383,0.017142138,-0.12130404,0.051271074,-0.02756015,-0.030068416,-0.083043754,-0.026139202,-0.10903297,0.05665686,0.045412403,0.013363437,0.06627484,-0.047610253,-0.061162435,0.02447515,0.020738753,0.024511069,-0.0018723472,0.015218596,-0.02169402,-0.08462054,-0.11866165,-0.079658374,-0.040015552,-0.016221775,0.055850685,-0.042525273,-0.06404158,-0.04050049,0.011779513,0.060437236,-0.000686258,-0.12303571,-0.0014165523,-0.015351743,0.05160285,-0.015304469,0.04692979,-0.026699176,0.00049439474,-0.043023977,-0.07273781,0.10029165,-0.094220094,-0.05218627,-0.021759588,-0.069413684,-0.051902134,-0.0074590025,0.0010776072,0.058090705,-0.017874392,-0.0045228694,0.0039142836,-0.028955264,-0.008595204,0.028291464,0.017552113,0.019397998,0.066523194,-0.05670252,-0.05136027,0.034198567,0.07018253,0.036491398,0.022569241,0.05773554,-0.023145244,-0.0032039043,-0.020701049,0.12617394,0.034757227,-0.03880129,-0.022852337,0.005277185,-0.01942632,-0.018274948,0.10142046,0.036849193,-0.07241174,-0.010684942,0.09123623,0.027889939,0.06747918,0.024485381,0.04739454,0.007665566,0.0509584,0.049814537,0.032469403,-0.07229939,0.04720511,-0.005855283,-0.06650325,0.038992997,0.043415222,0.011711835,-0.0023428923,0.0852718,0.046856623,-0.05125118,0.10525483,-0.06899977,1.8321591e-33,0.028265579,-0.041503206,-0.01927198,-0.055084325,-0.029010763,0.007700345,-0.02698872,0.0050500003,-0.07519774,0.03693674,-0.10470582,-0.016772853,0.012803953,0.075090595,0.0485732,0.0027515194,0.05898002,-0.01004105,0.04317598,0.047852334,-0.004506858,-0.0027325458,-0.0014494827,-0.047129404,0.047735,0.057556443,-0.05309992,0.07741966,0.0057303705,-0.024995146,-0.0044911085,-0.050308924,-0.0329674,0.095990084,0.018943498,0.008985714,-0.05538757,-0.014929363,0.046606738,0.029869027,-0.008333245,0.041369166,0.03220344,-0.069610246,0.08039932,-0.017574133,-0.047836825,0.037945002,0.009667257,0.11927313,0.073508926,-0.013239839,0.025350977,-0.01586705,-0.008051643,0.013599244,0.009079189,0.04996501,0.039124843,0.060400367,-0.038958993,0.061142165,0.037818704,-0.034576427,0.011624225,0.07358517,-0.14962307,-0.015464811,-0.052236162,0.03140237,-0.087676495,-0.020078013,0.018821245,-0.009299542,0.052750133,-0.08307876,-0.06323041,0.026962306,0.007134222,-0.0323324,-0.011284998,-0.00046243175,0.03837966,0.032111447,-0.071135215,0.047131483,-0.04921386,0.018090172,-0.026976243,0.045224495,-0.013536923,-0.017016998,-0.0443547,0.07754761,0.014163608,-3.901241e-33,0.094883665,-0.096371695,0.055712134,-0.09469355,-0.015468389,0.0634609,0.06390796,-0.013754491,-0.009432582,-0.038791694,0.042282272,0.06038793,0.0014544509,-0.08916443,0.055343073,0.012260754,-0.068548985,0.041468516,-0.03823819,-0.0017745913,-0.008607969,0.12797204,-0.024142036,0.024420645,0.07397275,-0.036039997,0.050357472,0.12071243,-0.0076839826,-0.004687581,-0.030952413,0.00430073,-0.020695588,-0.030130425,-0.016920183,-0.016896134,-0.04128588,-0.037114352,-0.012720994,0.009710071,-0.0044807433,0.05355395,0.047939286,0.043925453,0.03579222,0.10081298,-0.0516569,-0.06199107,-0.026161311,-0.023052994,-0.06313501,-0.024362374,0.027690249,0.036580145,0.04128105,0.06023204,-0.012439014,-0.0044953967,-0.0046066376,-0.061471213,-0.03749598,0.02576886,0.04045597,-0.01847482,0.10656606,0.017514667,-0.05557774,-0.022470009,-0.04294464,0.090004236,0.04157994,-0.045677897,-0.019857781,-0.016646827,0.027231595,-0.029928023,-0.13560216,-0.05161894,-0.0037953553,-0.032235604,0.043090753,0.03935031,-0.02979575,-0.04293129,0.058411177,-0.08366077,0.037526295,0.09362603,0.02061792,0.032139767,0.009750812,-0.033399146,-0.03696905,-0.012551707,0.0626161,-5.3594633e-08,0.068052664,-0.05894972,-0.04650544,-0.02369523,0.004792857,0.012991806,-0.02859801,0.028807405,-0.029975303,0.0014503843,-0.017844401,0.09532875,-0.03305147,0.059443247,-0.03207161,-0.063332826,-0.048542112,0.018101027,0.018495252,-0.00037466487,-0.11454938,-0.017155705,-0.115873076,0.03231872,0.04828994,-0.097822905,0.00904938,0.11271317,-0.044551402,0.01302189,-0.01264427,0.054404378,0.032821387,-0.003728604,-0.06138068,0.0033580803,-0.018105727,0.0038538335,-3.789248e-05,0.00918276,0.08790385,-0.08519844,0.012546703,-0.04444188,-0.012496776,0.013471984,-0.0053618634,-0.015132775,0.036066018,0.06763151,0.027966335,-0.019282065,-0.0677192,-0.024050005,0.004066334,-0.07424834,-0.060311764,-0.08594689,0.020032145,-0.034823146,0.039060686,-0.0061449464,0.16418496,-0.05235557 +3.2.1.14,"The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo-chitodextrinases can act. Activity is greatly stimulated in the presence of EC 1.14.99.53, lytic chitin monoxygenase, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. cf. EC 3.2.1.202, endo-chitodextrinase.",384,1.0,-0.041226037,-0.16445892,-0.0004378925,0.028469263,0.05405466,0.023720348,-0.0083046425,0.0030106087,-0.017951602,0.065040365,0.08309838,0.019929862,-0.023059905,0.078771986,-0.10553349,0.014057242,-0.042326666,-0.052199397,-0.008594022,0.039529815,0.056169067,-0.07280577,0.06643087,0.009425817,0.030201972,0.010714005,-0.014420663,-0.019419529,-0.033848405,-0.0816851,0.0115676485,-0.001483815,-0.08618566,0.022520099,-0.063820824,0.073591836,0.020957267,-0.009838922,0.049213473,-0.0109066805,-0.014276281,-0.06367376,-0.042291474,-0.06273366,0.01027579,-0.06876561,-0.04149929,0.021425327,0.03736171,0.03150859,0.0028871957,-0.00073931017,0.024300562,-0.062115528,-0.0061389124,0.084387384,-0.018392507,-0.06253194,0.019512402,0.13224044,-0.013410975,-0.004720114,0.0072217425,0.005834624,-0.08439044,-0.04191985,0.035843536,-0.02423134,-0.0067032566,0.010300525,-0.032431282,-0.054806024,-0.07692184,0.011133182,0.046048492,0.08410183,-0.06828207,-0.09606347,-0.02287057,-0.028010478,-0.016375959,-0.020134032,0.052754685,0.11349882,-0.0027963826,-0.026659824,0.06540261,-0.007272452,0.022297181,0.12590018,0.031229379,-0.013801872,0.0067511545,-0.00085365854,0.019213496,-0.014087442,0.02522095,-0.006062063,0.03773174,-0.04867571,0.015529815,-0.031912588,0.030592542,-0.015868992,0.0507046,-0.0046124435,0.07044518,0.04028826,0.048258528,-0.08777573,-0.0030446362,0.031124284,0.029926643,-0.055758957,-0.11318078,0.10573389,-0.010480619,-0.0603497,-0.00023609241,0.0146541605,0.0006730644,0.02171864,-0.03159858,0.105609104,-0.020988163,0.015289307,-0.030706348,3.7969584e-33,0.019554695,-0.027991273,0.06511817,-0.018547535,-0.0058367997,0.04645651,-0.083039336,-0.020247295,-0.03348629,-0.01203557,-0.050083783,0.019933837,-0.045555707,0.09936618,0.019420715,0.06999454,0.018106215,0.01481689,0.028755853,-0.004272202,-0.0044660103,0.045469936,-0.03187907,-0.034378007,0.076414764,0.084172636,-0.0844608,0.05368943,0.06456108,0.008799541,0.06103423,0.014858616,0.0054272986,0.06339263,0.014772154,0.05823808,0.0025352405,-0.0566104,0.033481218,0.040202986,0.080578834,0.07150196,-0.026100885,-0.050404456,0.015426668,-0.03505499,0.042537306,0.026510376,-0.022637516,0.037835676,0.056449134,-0.029415654,0.09079899,0.024394793,0.04382141,0.032685883,-0.007278749,0.021923061,0.08110931,0.01509806,-0.05078498,0.029840404,-0.006158623,-0.047814958,0.0653662,-0.003711393,-0.008960221,-0.032001548,-0.09248496,-0.037529703,-0.01730548,-0.010664425,0.03720187,-0.028928168,0.0475229,-0.0065282024,-0.105220586,0.0021169404,-0.041555695,0.034617286,0.07417283,0.032892335,-0.02904368,-0.031812966,-0.022175293,0.060210302,-0.020568563,-0.09457757,0.014653609,0.03793629,0.0009948598,-0.08623508,-0.0168435,0.057264533,-0.023539731,-4.8117182e-33,0.10014572,-0.077119805,0.0932326,-0.04576304,-0.046603728,0.0511614,-0.048867892,0.043512475,0.008285745,-0.0214906,0.04630087,-0.0055733216,0.07369617,-0.07936577,-0.058613516,0.006020859,-0.00057610177,0.07301586,-0.027232207,-0.03200779,-0.09943034,0.03429754,0.070997015,0.025222514,0.11878279,0.014414122,-0.00988752,0.027643245,-0.022031778,-0.022674294,-0.0962852,-0.034977026,-0.04779081,-0.05825038,0.0012162705,0.025202556,-0.07458226,0.02445432,0.06850785,-0.0716027,-0.04554838,-0.006878052,0.07196195,0.014070361,0.044214405,0.06282926,-0.03567181,-0.10716508,-0.03178705,-0.011006224,-0.0094707925,0.008321856,0.013135782,0.03398091,0.043314368,0.032994274,0.020835027,0.06887,0.014704146,-0.02080802,0.0044892137,0.025804479,0.06135282,0.03675181,-0.017539367,0.08004724,-0.0632599,0.056413766,0.06592253,-0.099186495,0.060820144,0.01529121,0.00463813,0.035151068,0.06608392,0.052376,-0.12883072,-0.059848417,-0.066388965,-0.050777536,0.04682727,-0.02049233,-0.09257875,-0.07745334,-0.008483352,-0.038430944,0.005624819,0.11851817,-0.053857736,0.027547773,-0.0020405618,-0.03017647,-0.034219045,0.018082254,0.07851147,-4.051051e-08,-0.002010541,-0.071906015,0.050059557,-0.12603714,0.010822067,0.037133098,0.021510987,0.00063879805,-0.024607027,-0.037237335,0.0732295,0.08256741,-0.0124054765,0.031075517,-0.035167146,-0.00014676491,-0.012602154,-0.009156909,0.021080231,0.025825016,-0.10665148,0.055028126,-0.07796114,0.06334654,-0.061342634,-0.03905279,0.02311213,0.058320686,-0.07120521,-0.05191171,0.013489116,0.028209794,-0.0643521,-0.024638878,-0.09371988,0.017639479,-0.057826646,-0.018149706,-0.018545395,0.010601209,-0.0012291203,0.026310295,-0.05444948,-0.026043503,-0.047102463,-0.025265774,0.035753738,0.05406227,0.00806451,0.039920766,0.04194669,-0.032671887,-0.06471723,-0.12893455,-0.08997976,-0.012422943,0.066314556,-0.040495988,0.014174425,-0.030101307,-0.08615175,-0.07931769,0.13295238,0.009224658 +3.2.1.15,The enzyme catalyses the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans. Different forms of the enzyme have different tolerances to methyl esterification of the substrate.,384,0.99999994,0.048864625,-0.13442074,0.0061419834,-0.031976636,-0.0055852435,-0.011041545,-0.008039387,0.026182018,0.03406222,0.036585733,0.048727524,-0.020554217,-0.053246472,0.030427542,-0.09728418,0.028261,-0.073363766,0.042439695,0.029885927,0.051306617,0.16080771,-0.028768618,0.0033640624,0.059571154,0.076144636,-0.021327734,0.08565744,-0.019693509,-0.013346101,-0.098382145,-0.021441128,-0.038628627,0.06267199,-0.028408937,0.017692778,0.08775089,-0.055999674,-0.08711906,0.05489337,-0.027019067,0.02438216,0.017500378,0.02465747,-0.05102158,-0.05248654,-0.0074324217,0.014535048,-0.014025104,-0.020632163,0.0059820046,0.015096374,-0.13725756,-0.04163545,-0.03864185,0.011280959,0.062185507,-0.06764371,-0.050023794,0.03174949,0.08302875,0.079024315,0.04259319,-0.056611776,0.01497071,-0.03330443,-0.0628744,0.05016127,-0.04258326,-0.07100656,-0.021444691,-0.031130753,-0.042027432,-0.004095511,-0.007933442,0.0073033976,0.032962658,-0.00078090315,-0.10489642,0.07747664,-0.04172723,-0.002661252,0.007663961,0.027570955,0.0015979066,0.02781934,-0.012127088,0.070079334,0.047651853,0.031486217,-0.011100793,0.075350374,-0.00080604944,-0.07030204,-0.008211335,0.015197177,0.047013424,0.0059618573,-0.04246448,0.07977542,-0.037529074,0.03243301,0.04509266,0.044634316,-0.06195564,0.014114763,0.07720676,0.04062611,0.07154279,0.0107055055,0.030746201,-0.043957807,-0.010168477,0.022880375,0.043831363,-0.08685426,0.067300186,-0.012585111,-0.042986687,-0.045702707,-0.01247184,-0.018262306,-0.024158528,0.037633866,0.045314096,-0.07002028,0.049745265,-0.040058732,-3.873543e-34,0.082942486,-0.009232835,-0.024994334,-0.10173443,0.051381044,0.05534713,-0.08334525,-0.037305918,0.037551988,-0.03553731,-0.1414256,-0.0245825,0.008524335,0.07500092,-0.038604885,0.029520972,0.0556376,-0.0143303815,0.0032340914,-0.01966059,0.007523685,0.056664128,-0.07686365,-0.03780569,0.034882616,0.03107282,-0.024880761,0.045452964,0.10510125,0.010843691,0.005426226,-0.06935359,-0.09479574,0.041752655,0.05241423,0.07107086,-0.0062059253,-0.032065112,-0.0014686099,-0.009957289,0.036039185,-0.00030895177,0.022536717,-0.0102482345,0.007964737,-0.032644574,0.019784996,0.073682114,-0.010685525,-0.035167277,0.046526622,0.008519622,0.01990392,0.019194568,-0.0025999546,0.006304596,-0.08939092,0.0010067787,-0.0046275095,0.08329982,0.0024065943,0.06562973,0.02922752,0.036303896,0.008574482,0.040605474,-0.050795272,-0.01787407,-0.0053634164,0.005865642,-0.04868392,-0.08537062,0.007614858,-0.06468841,-0.062317282,-0.07015445,-0.022630785,-0.018801205,0.004919465,-0.016902603,-0.03982462,0.03166714,0.00024761722,0.005795203,-0.0129169505,0.032908246,-0.0108078765,-0.009294685,-0.022941956,0.073006436,0.018940447,-0.045683935,-0.02578836,0.0874679,0.029471766,-1.7965624e-33,0.052299753,-0.08752165,0.111232,-0.06794212,-0.056645926,0.07590648,0.023770442,0.0014527334,0.004918507,-0.08809238,-0.0050259754,0.021086639,-0.029911254,-0.09435709,0.015116592,0.032555714,-0.010613805,0.13480675,-0.042363796,-0.010842018,0.0028295366,0.10925592,0.021194898,0.06846681,0.07795464,-0.018038698,0.010957286,0.022264605,0.030679366,0.051087376,0.0067918003,-0.0354174,-0.063892215,-0.025855714,0.008025548,0.056953426,-0.020243628,0.013579079,0.048031814,0.057904575,0.0007967624,0.037917078,0.055994753,0.04299831,0.07966968,0.069467194,-0.06410456,-0.019388903,-0.0013334078,-0.027326513,0.02487097,-0.039868902,0.029592639,0.045411445,0.019911831,0.026999207,-0.00022676536,0.03149101,-0.036954913,-0.052865956,-0.065556414,-0.07910693,0.050168764,-0.07381337,0.040746816,0.014423119,-0.061130412,0.056678563,0.054838296,-0.003921243,0.014574122,0.01357172,-0.09379422,0.028537437,-0.009837602,0.014904336,-0.12227884,-0.11988206,0.01829166,-0.046762295,0.10804045,0.11985462,-0.010367524,-0.055314608,-0.023776777,-0.049981367,0.08925272,0.12104701,0.0047264206,0.030827258,-0.0026928445,-0.046218906,-0.018042011,0.07764051,0.05050521,-3.1278788e-08,0.049443636,-0.01735862,0.0038699638,-0.05876706,-0.03044365,0.02222305,-0.022482222,-0.014893624,0.0274672,-0.09110522,-0.024889251,0.07429452,-0.018855685,0.080573894,0.0079225665,0.015227473,-0.039720193,0.008528392,-0.029312504,0.020864865,-0.09211535,-0.031781435,-0.09086362,0.058935583,-0.062848315,-0.04508543,0.044372883,0.076421835,-0.048777126,0.046002425,0.050471548,0.038718972,-0.046867073,-0.054822646,-0.052180942,0.09634645,-0.017880913,-0.054170333,-0.023621934,0.032175556,0.053455498,-0.124156676,0.0628719,-0.0022059993,-0.04109234,-0.026011808,-0.016255997,0.014602159,0.030784367,0.0725262,0.007314761,-0.029115327,-0.0774738,-0.082491264,-0.066548355,-0.073300384,-0.035152912,-0.0464474,-0.0034095615,-0.050833892,0.035177767,-0.01788269,0.11528637,-0.07052816 +3.2.1.17,cf. also EC 3.2.1.14 chitinase.,384,1.0,-0.093439266,-0.080666885,-0.026324177,-0.0075998968,0.063340314,0.00052695896,0.034124386,0.111314476,0.039074764,0.003493691,0.11602034,-0.116166525,-0.07837842,0.06391905,-0.023347337,-0.062650375,-0.05740042,-0.076958045,0.0056020715,-0.016221963,-0.045964334,0.003976904,0.029476503,0.01606707,-0.0066476436,0.052258812,-0.024319168,0.015730202,0.007104248,-0.12883103,0.020835612,0.028036356,0.050629344,-0.023307161,-0.0058026398,0.00016326098,0.036853682,-0.113963045,-0.02370769,0.0890271,-0.045514718,-0.00954907,0.02331034,-0.0019271006,-5.3656993e-05,-0.00078457495,-0.003158103,0.051747944,0.028652146,-0.020213654,-0.027952258,-0.0174263,-0.0016698241,0.02146404,0.008893332,0.1262347,-0.066291474,-0.056400366,0.008080683,0.07204863,0.017939119,0.025840415,-0.024339465,0.023576379,-0.03191766,-0.0025599864,-0.022176424,-0.07382704,0.041323733,0.00042096936,-0.02954714,-0.06916725,-0.103406325,0.04372424,0.044457044,0.110239,0.010565653,-0.11267097,0.08144941,-0.094717756,-0.022938743,-0.0419648,-0.032001015,0.019444233,0.019433707,-0.035788853,0.00810687,-0.02588537,-0.016156612,0.043506097,0.066941276,-0.044355914,0.03743986,0.05794496,-0.07129154,0.08090859,0.03729989,0.022403304,0.021487596,0.020764045,-0.002151854,0.035152495,0.0017988425,0.032157872,-0.053297788,0.009878521,0.09205277,0.03209238,0.02157393,-0.048553076,0.00013703795,0.019981977,-0.0653855,-0.11564718,-0.07132505,0.111981414,-0.025104405,-0.024879841,0.08887842,0.06463136,0.011578004,-0.038849685,-0.046074677,0.046002325,-0.051740076,-0.007392134,-0.054936104,-1.18794945e-33,-0.0012420389,-0.0010718053,0.014077026,-0.0010791471,-0.017689405,-0.005113228,-0.07092653,-0.006527014,-0.06581574,-0.06051162,-0.06614921,-0.027984364,-0.07789679,0.015634216,-0.0068634297,-0.040994808,-0.007405967,0.036727015,-0.01883325,0.010985354,0.015028755,-0.0048686387,-0.010766935,-0.030346941,0.14668597,0.042023696,0.00041639135,-0.034136012,0.07743213,0.054670587,0.08368335,-0.050589945,-0.051308565,0.0068659075,-0.09963729,0.027025912,-0.035041116,-0.06427593,-0.020364601,-0.0006149976,0.089705735,0.09393911,-0.026924519,-0.04527524,0.038216315,-0.005595282,-0.0003250721,0.05994005,0.08922249,-0.051338434,0.032332964,-0.024280587,0.017327216,0.0021718268,0.05700648,0.021200137,-0.007194919,0.05867114,0.07151212,0.035159435,0.012789727,0.09132357,-0.07152975,-0.024345968,0.019525804,0.038971875,-0.032300554,-0.051877428,-0.047534164,-0.05234443,-0.10331613,0.009844818,0.10765761,0.022221403,0.073231496,-0.05379242,-0.060505915,0.055733293,-0.08036618,0.01006555,-0.115420885,0.02054551,-0.041728273,0.0775333,-0.0574235,0.0019484137,-0.0012482286,0.0046939645,-0.020576986,0.0029858274,0.023692125,0.008287834,0.040769834,0.04908627,-0.10586243,1.41606625e-33,-0.017865904,-0.05072743,-0.02411402,-0.0033075295,0.0070173675,0.09351318,0.019845929,0.055650786,0.02958244,-0.008261483,0.090681456,0.0066027134,0.05642698,-0.15429847,-0.024650313,0.056160018,-0.03381219,0.0051839673,-0.068389334,0.02322788,-0.033961475,0.08132693,0.084154464,0.038559183,0.016343666,0.021270728,-0.002073461,0.053324632,-0.038476598,0.007287175,-0.0011203358,-0.007854283,-0.016688623,0.0035582497,-0.08729188,-0.05478836,-0.0043802294,-0.015156437,-0.013108703,0.018501837,0.029754799,0.035189815,0.0023355894,0.07470326,0.028961921,0.092092246,0.08809751,-0.08267494,0.0060453867,0.028793443,-0.007951027,-0.076285705,-0.046213415,0.04535054,0.034590423,0.04583452,-0.054202456,0.02143681,0.0051009688,-0.031481832,0.028522277,0.05531958,0.04339963,0.0005832189,0.088900946,0.114979856,-0.18718913,0.08996329,0.042529084,-0.02183243,0.024857627,0.016039835,-0.0040024812,0.01915188,-0.005824436,0.034847308,-0.056079574,-0.029340023,-0.012516535,-0.021743901,-0.036854852,-0.0076440745,-0.09703091,0.020786,0.051429905,-0.06152276,0.031637754,0.03743645,-0.008585505,0.053960215,-0.08895758,0.037215315,-0.029106334,0.10367106,0.04604526,-1.8113667e-08,0.026590033,-0.0031859532,0.0278062,0.017296946,0.084155664,0.015277458,0.014926772,0.02111805,0.04416268,0.0309804,-0.0049781096,0.027287109,0.021571977,-0.012844922,0.022764683,-0.018771628,-0.05882712,0.08536176,-0.02047674,-0.03660865,0.010954,0.08470312,0.033100713,-0.048868176,-0.011249376,-0.038034454,0.032690935,0.030866124,-0.03656097,-0.032548375,0.00031870627,0.053149186,0.034085173,-0.045094572,-0.014593838,0.061828967,-0.07509971,-0.0344085,-0.03298024,0.070212774,0.013569744,0.020777421,-0.056136232,0.015030222,0.037929162,-0.03275195,0.01238082,0.027940352,0.025303518,-0.073291235,-0.04373701,0.0031391664,-0.012154801,-0.02083578,-0.017898366,0.062687054,-0.072272316,-0.034092642,-0.020182488,-0.068850584,0.01970006,-0.10047292,0.052271783,0.07630052 +3.2.1.18,"The enzyme does not act on 4-O-acetylated sialic acids. endo-alpha-Sialidase activity is listed as EC 3.2.1.129, endo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase.",384,0.99999994,0.053533062,-0.10928824,-0.045974113,-0.05434707,0.06581336,0.04691793,-0.045196388,0.016291078,0.032831684,0.010262162,0.05436973,-0.055544537,-0.14730926,0.07823733,-0.009301862,0.029628556,-0.068441205,-0.047142662,-0.01556014,-0.043221522,0.089479774,0.0052519683,-0.021600688,-0.009156307,-0.0019280809,-0.00449028,0.009294279,-0.05907999,-0.03276201,-0.09936096,-0.011215356,-0.07344622,0.097279005,-0.03101697,0.08867161,0.03816157,-0.056704093,-0.116152376,-0.011829368,0.06021063,0.096044526,-0.051459838,-0.009686373,-0.0035866704,-0.02685736,-0.039638214,-0.002147882,-0.047661237,0.022186736,0.02635932,-0.066905595,-0.11067471,-0.028581586,-0.016480798,-0.07312677,0.0059158113,-0.009173675,0.017370095,-0.040390898,0.10647648,0.07469363,0.01081398,-0.0041465466,0.0022890954,-0.008078169,0.027400823,0.1315788,-0.11885867,-0.06840595,-0.032610103,-0.05129491,-0.04526889,-0.03199958,0.052878637,0.021612283,0.035203077,0.014722225,-0.011664831,0.06367281,-0.085594594,0.004276423,-0.041110132,-0.04703844,0.010070234,-0.010541582,0.011893271,-0.074986264,-0.0116139045,0.060810555,0.024202395,0.041510694,-0.06039114,-0.007549801,-0.062358897,0.053043354,0.0461096,-0.016179977,0.0008537016,0.02410447,-0.07522398,-0.0016916313,0.06826658,-0.10583574,-0.053992156,-0.0029088657,0.10180466,0.025763286,0.012955601,0.009537905,0.05124887,-0.030933155,-0.07381845,0.10383218,-0.03476789,-0.00483554,0.061819095,0.034363005,-0.03466982,-0.034292765,0.007983064,0.04117083,-0.0626945,0.107414275,0.04666028,-0.016709873,0.12557808,-0.05606181,-2.9984155e-35,0.06262756,0.051359516,0.014482556,-0.05450937,0.01062098,-0.00034558916,-0.065836295,0.028605802,-0.061246816,-0.045916297,-0.07586598,-0.015560031,0.0001351478,0.0086200135,0.053347755,0.052007545,0.11629385,-0.0221922,0.0028694142,0.0072498186,0.05812921,0.028488304,-0.009388847,0.003141132,0.03031345,0.08204316,-0.03506882,0.021035537,0.025413778,-0.0043259817,-0.026263902,-0.05218461,-0.09394998,0.024858454,0.06102351,-0.046691407,-0.023966538,0.024183849,0.0032973955,0.00765968,0.005026781,0.104370326,0.010380873,-0.040789407,0.03752601,-0.07210605,-0.013687275,0.047100525,0.11871629,-0.056632064,-0.019382074,-0.050357006,-9.3102164e-05,-0.027186759,0.019416759,-0.0133031495,-0.02349215,0.08386173,0.0232685,0.013746889,0.016155737,0.0643462,0.008137622,-0.0021318914,-0.063934624,0.017600752,-0.04359645,-0.010059714,0.006488583,-0.008147869,-0.017301012,0.020492166,0.015730541,0.008287446,0.0017261927,-0.07344717,-0.034457803,-0.025808627,0.07261423,-0.041145418,0.06782154,-0.014863149,0.042420752,0.05348117,-0.08826239,0.013776183,6.784893e-05,0.0276935,-0.01677107,0.050552227,0.034456596,-0.039161436,-0.02286863,0.05844354,-0.019171325,-1.4096292e-33,0.08093729,-0.014526041,0.011517545,-0.10172645,-0.029357951,0.10620263,0.065931685,0.04994134,0.050435644,0.019614141,0.118320614,-0.02825843,0.003998092,-0.12196522,0.045780387,0.0007950318,0.02639335,0.09043269,0.015502797,-0.053837992,-0.021635924,0.014820389,0.020762857,0.065391704,0.11762797,-0.0090633305,0.010279727,0.050255112,-0.053921092,0.027159933,0.014442265,-0.06112606,-0.016575826,-0.038509227,-0.035537466,0.006858707,0.010088301,0.01173608,0.023619901,0.0068353266,0.037145834,0.005326582,0.089079514,0.092869975,0.035458036,0.047026698,-0.07835657,0.0085947225,-0.048585493,-0.03561922,0.054917015,-0.06967187,-0.021826662,0.035413675,0.043991238,0.04002184,0.029974625,0.030023685,-0.1491715,-0.056931295,-0.08113683,-0.04468531,0.028616328,-0.06033797,0.057969827,0.022667276,-0.046617314,0.053492635,0.04189715,-0.07393893,0.03976364,-0.03694084,-0.035539065,0.056175906,-0.015804704,-0.028841285,-0.067598164,-0.09009296,0.058569606,-0.06353106,-0.054079637,0.01874132,-0.0017320118,-0.017473733,-0.0011223991,-0.06655142,0.051617153,0.0677891,-0.011305866,0.088864274,-0.048900798,0.017088436,-0.06497873,0.03140155,0.06571319,-3.2202287e-08,0.05911842,-0.019523822,0.049204126,-0.086732805,-0.024037525,-0.022562489,0.03869838,0.014723386,0.076571055,-0.028576666,-0.04298144,0.0524579,0.030668784,0.037400465,0.0063909036,-0.04297228,0.030115929,0.0722417,-0.010760554,0.018173197,-0.0518247,-0.0061603435,-0.10200724,-0.065299466,-0.019916883,-0.051281076,-0.01677891,0.06112579,-0.042915963,-0.004312957,-0.004918078,-0.014057989,0.010132559,-0.02006074,-0.042478073,0.040578075,0.02763723,-0.03029548,-0.04490155,0.043560587,0.036253452,-0.044620164,-0.062366836,0.038405336,0.029788319,0.032500442,0.00530223,-0.030552581,0.008712774,-0.011072127,0.054062918,-0.057581224,-0.029738763,-0.014731688,-0.06380622,-0.08275681,-0.018007819,-0.022824172,0.031284515,-0.08652008,0.107788,-0.013392285,0.10555636,0.01230826 +3.2.1.20,"This single entry covers a group of enzymes whose specificity is directed mainly towards the exohydrolysis of (1->4)-alpha-glucosidic linkages, and that hydrolyse oligosaccharides rapidly, relative to polysaccharide, which are hydrolysed relatively slowly, or not at all. The intestinal enzyme also hydrolyses polysaccharides, catalysing the reactions of EC 3.2.1.3 glucan 1,4-alpha-glucosidase and, more slowly, hydrolyses (1->6)-alpha-D-glucose links.",384,1.0,0.032499384,-0.08995255,-0.06622964,0.021889977,0.06180714,-0.024611821,-0.047908127,-0.024320701,0.08475599,0.0066542216,-0.01765834,0.028884051,-0.052130632,0.009689353,-0.09226844,-0.029249163,-0.030234931,-0.0021184266,-0.07379728,-0.047780987,0.05229956,-0.061404306,-0.006201058,0.024747493,0.050235804,-0.07584905,0.06559845,-0.047459215,-0.018062001,-0.110071294,-0.0047577024,-0.07961618,0.0629851,0.008602878,0.037643008,0.117825575,0.0014319529,-0.050313257,-0.013175137,0.0041021956,0.045309927,-0.027629942,0.03691455,-0.03109371,-0.06724363,-0.058142044,-0.04866654,-0.017583448,-0.01833015,0.02193627,-0.0022640654,-0.078517936,-0.08136019,-0.008744179,0.057602093,0.0060074236,-0.083226405,-0.006440214,0.020680234,0.08149662,0.056449447,0.046597883,-0.0018317924,0.01936547,-0.044603,-0.06830273,0.10196264,-0.05793065,-0.075346954,0.009125328,-0.11089936,-0.00047019374,-0.03904731,0.022999248,0.028035045,-0.01853635,-0.046361417,-0.018208232,0.015467272,-0.016688457,0.072527476,0.008709366,-0.009384025,0.054633405,-0.015841326,0.0016046942,0.017965162,-0.006756002,0.059710965,0.003016804,0.031850323,-0.070113294,-0.0009997546,-0.025221959,0.05812488,0.0056977933,0.020469328,-0.049054798,0.058534235,-0.052995123,-0.053215377,0.04971648,0.058191642,-0.035537712,-0.031678647,0.051818624,0.013295942,0.14795962,0.029768173,0.04147596,-0.024600808,-0.038190253,0.049864564,0.018424703,-0.11701499,0.054687496,0.039217364,-0.08064991,-0.006688235,0.0038080525,0.008755861,0.027912492,0.13346498,0.028294673,-0.060228035,0.061969537,0.004227483,1.8375238e-33,0.04013183,-0.04323329,-0.0007808372,-0.03915207,-0.008306051,0.003002249,-0.05291573,0.0037271748,0.0025528935,0.04748869,-0.06477948,-0.0027087436,0.032376014,0.14683786,-0.0085061295,0.047177,0.026255094,-0.028201815,-0.021738105,0.018165424,0.00419428,0.062924206,-0.03823792,0.011827585,0.061064243,0.03381709,-0.05974195,0.042294573,0.08552313,-0.012333445,0.02262613,-0.049499575,-0.112238735,0.091104075,0.021665363,0.07274539,-0.032544494,-0.024894347,0.086794116,0.05078534,-0.016381286,-0.009504252,0.040693786,-0.12537545,0.02690364,0.008632404,-0.011848258,0.078780875,-0.02918964,0.118249826,0.05027192,0.006020547,0.016847681,0.0112314895,-0.022967711,-0.006203636,-0.02967537,0.01584233,0.000869564,0.10030206,-0.03953451,0.07396133,-0.014074764,-0.02376935,-0.028110376,0.032995947,-0.059912235,0.01681094,-0.023756506,0.018486805,-0.134589,-0.006489374,0.04149393,0.0007320969,0.042312164,-0.09227901,-0.065371774,0.0058853175,-0.012878884,0.005018757,-0.01778523,0.014512553,0.03717914,0.054828733,-0.049324285,0.049749877,-0.04423021,-0.042575907,-0.02376576,0.072319075,-0.024997985,-0.01749762,-0.077701375,0.096069165,0.04021263,-4.9295487e-33,0.14969839,-0.09161206,0.08198028,-0.07734615,-0.017964954,0.018870225,0.020649478,-0.025702855,0.023299778,-0.015686953,0.05293026,0.04644637,-0.0013326114,-0.07429786,0.026747683,-0.022979898,-0.056650784,0.08356084,-0.007719132,-0.0008989696,-0.010070389,0.084841765,0.012378771,-0.042132884,0.117204234,-0.024319418,0.060887642,0.05363473,-0.013146791,0.036399744,-0.06426055,-0.011935435,-0.049412414,-0.018195124,-0.05351324,0.04270087,-0.062036652,-0.033911727,0.019608233,-0.032997623,0.016534477,0.060972456,0.036540486,-0.0130377915,0.05745354,0.09084027,-0.090664886,0.03415252,-0.042351883,0.0035990726,-0.013064428,0.023948211,-0.014382993,0.06655914,0.031126328,0.037493385,0.020863667,-0.03696101,-0.042721737,-0.05382545,-0.05393997,-0.025733965,0.083387114,-0.02271933,0.03932657,-0.017688738,-0.031716928,-0.021067401,0.012309382,0.049951926,0.08027815,-0.09698845,-0.05691215,0.031565983,0.04618963,-0.049272213,-0.11434807,-0.046279334,-0.032904893,-0.07520989,0.024089118,0.05335555,0.036768295,-0.091665044,0.03729026,-0.046779286,0.009829975,0.08783184,0.031985883,0.06284832,0.009638637,-0.001467329,-0.011987759,0.029307865,0.06352543,-4.3233108e-08,0.052458066,-0.039019864,-0.032884825,-0.033577964,-0.020284822,0.057834793,-0.02263321,0.061164193,-0.011792613,-0.00129635,0.016156198,0.11071538,-0.022978997,0.015721371,-0.031499386,0.0062782136,-0.0871644,-0.042067748,-0.0072144414,0.0063645146,-0.12696168,-0.018295906,-0.11355547,0.026427573,0.0032486117,-0.08052607,0.02755357,0.040998317,-0.07864795,0.004605511,-0.007963854,0.061156016,-0.0146768065,-0.06646485,-0.052287865,0.026538247,-0.03948854,-0.005486602,-0.03558413,-0.020900467,0.03185664,-0.047520753,-0.0162793,-0.030207964,0.013313891,0.019860048,-0.028833799,-0.018707348,-0.0042034606,0.04951079,0.008370471,-0.04992022,-0.025211692,-0.048303954,-0.021205837,-0.0259776,-0.04584509,-0.0804503,0.003912038,-0.035151128,0.017746173,0.01570353,0.17905566,-0.023891555 +3.2.1.21,"Wide specificity for beta-D-glucosides. Some examples also hydrolyse one or more of the following: beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.",384,0.99999994,0.0018873884,-0.10815788,0.0050447923,0.004253909,0.02236374,-0.04691019,-0.021183936,0.012712518,0.007962256,-0.017587438,0.0058426075,0.08104025,-0.08188265,0.07053439,-0.048945572,-0.0205409,0.019178944,0.08107465,-0.0552476,0.025839442,0.054326173,-0.008094281,-0.0033232484,0.052108932,0.02924687,-0.040461145,0.051218525,-0.057821512,0.025579628,-0.07268533,-0.013001825,-0.012535167,0.046167355,-0.027650723,0.040684246,0.097312,-0.08825403,0.014609037,0.042986073,-0.013333555,0.00874365,-0.03325784,0.08803888,-0.008157862,-0.023176871,-0.07219882,-0.05466343,0.04469602,0.04091504,0.024532506,0.064796574,-0.13420227,-0.09093609,0.03070085,-0.01229732,-0.064783804,-0.07420398,-0.009908741,0.027962074,0.054616358,0.037481707,0.09928933,-0.026228487,0.024037238,-0.10111114,0.006955525,-0.01056666,-0.020713491,-0.036461428,0.027695198,0.0128816245,-0.042347476,-0.029163094,0.023863403,0.021098597,0.041196138,-0.014443608,-0.040677853,0.011682052,-0.039515898,0.006784226,0.047119178,0.09303941,0.004426949,0.038784865,0.06036677,-0.04861676,0.078814454,0.05118945,0.0057252483,0.0004919411,-0.0767526,0.0064702844,-0.011564466,0.03026767,-0.016497051,0.06955141,-0.062245686,0.014217423,-0.042525064,-0.043393977,0.024112873,0.010692908,-0.0022576745,0.002832373,0.058636867,-0.0014964404,0.026180198,0.01860772,-0.061102755,-0.086063355,0.028336652,0.04164698,-0.060570166,-0.071722746,-0.07394353,0.05216615,-0.058030162,-0.020664044,-0.047261987,-0.02070501,-0.062626995,0.027616635,0.0031168505,-0.028329784,0.10858475,-0.029714754,-4.636966e-34,0.06471536,-0.018636297,0.02075392,0.03905705,-0.04385299,-0.019302227,-0.043146417,-0.056632705,0.019682087,0.051925372,-0.06030365,0.015215732,-0.00918906,0.08401321,0.04153285,0.056285292,0.051864192,0.0036178208,0.07202033,-0.014483604,-0.0012113997,0.05009076,-0.043274056,-0.022438336,0.044708483,0.0065877023,0.0069440883,0.054097056,0.09630227,0.013103458,-0.035503138,-0.085551485,-0.009542245,0.07572604,0.0020327487,0.12565602,-0.18761012,-0.0074782777,0.046551246,0.016183246,0.00517529,-0.0049425443,-0.018011777,-0.04034607,0.07407292,0.03234956,0.013943771,0.0049840314,-0.06211909,0.01829473,0.019772036,0.11453538,-0.038487185,-0.00849711,-0.033243835,0.014533791,0.020979825,0.024439853,-0.023932071,0.096745305,-0.053899907,0.08538498,-0.008063584,-0.05000877,-0.021135468,0.021507911,-0.07789286,-0.045761503,-0.10250662,-0.0454741,-0.067860425,-0.02109127,0.07677148,-0.014342537,-0.013208075,-0.08321577,0.074488975,-0.018111488,0.0025298311,-0.052184016,-0.02705009,0.004837327,0.01419251,0.06074378,-0.08689935,0.07564481,0.0023450437,-0.063399695,-0.003965327,0.010907271,-0.09183625,-0.009230283,-0.053198937,0.028703507,-0.016999064,-2.3192296e-33,-0.008861915,-0.089811265,0.0034479822,-0.041011706,0.0053439694,-0.00035418943,0.029330863,-0.06299649,0.043930445,-0.05673074,0.015389402,0.040373154,-0.115054525,-0.12332201,-0.1030344,-0.0076463823,-0.0012473937,0.061480578,0.0027765173,0.01975011,-0.0062289853,0.06705331,0.026468456,0.0062020053,0.12737602,-0.02826362,0.018855093,0.033589434,0.04808133,0.04628544,-0.0035332702,0.069668405,0.014579897,-0.06892195,-0.05493701,0.002788542,-0.03277549,-0.0046644136,0.03596218,0.036834672,0.00069407537,0.023494028,0.047568932,0.07526743,0.11366083,0.09248358,-0.06298296,-0.043264143,0.04171032,-0.007392486,-0.03521162,-0.038601246,-0.002249693,0.08695458,0.082015775,0.030158553,-0.004958401,0.06344681,-0.003984461,-0.057722367,-0.03511575,-0.004943907,0.025305193,-0.040893592,0.025652837,-0.0064131888,-0.058808442,-0.012001753,-0.03830583,0.043849815,0.034557607,-0.090585746,-0.048697338,0.06256192,0.0074502467,-0.031242441,-0.051398788,-0.110720046,-0.037350927,0.023337424,0.026473606,0.11397917,-0.011121638,0.053559147,0.08284813,-0.03059025,-0.020330228,0.0926675,0.019769093,0.022837942,0.000383477,-0.02834762,-0.009887866,0.04357173,0.07267179,-3.323019e-08,0.060189668,-0.0015620533,0.01489751,-0.0677849,-0.028184673,-0.01223965,0.0022015767,0.042882137,-0.003287587,0.0045824596,-0.07035674,0.14923176,-0.022848835,-0.011777753,-0.016830117,0.028061824,-0.042200632,0.0114618745,-0.031069119,-0.023518804,-0.061028756,0.032957535,-0.007511912,0.00837961,-0.026760032,-0.08208812,0.065526806,-0.05484167,-0.029372657,0.02452475,0.030345362,0.03080599,-0.011511981,-0.12047146,0.081372365,0.09372348,-0.061147336,0.028888712,-0.009292542,0.032556325,-0.032624338,-0.05335306,0.015731156,0.031545173,0.0143787535,-0.015387089,-0.049776033,0.062336013,0.013465304,0.047387056,0.03681949,-0.033830255,-0.0931187,-0.101543896,-0.064102195,0.015404988,0.0042746724,-0.056396663,0.005303515,-0.1344277,0.010996626,-0.0076740733,0.10239448,0.00017746654 +3.2.1.22,Also hydrolyses alpha-D-fucosides.,384,1.0,0.007917126,-0.074748434,-0.059432905,0.016953556,0.05171897,-0.057418123,-0.00629835,0.049828377,0.046238706,0.0014145738,0.007677557,0.028382849,-0.060820255,0.025425794,-0.061893687,0.0013913126,-0.019486707,0.05541282,-0.020921797,0.019979177,-0.00094073516,0.005793052,-0.012015391,0.035174575,-0.04292253,0.015400498,0.05135152,0.0154019175,-0.011560759,-0.07964579,0.021927675,-0.00052271446,0.07491822,-0.022293368,0.029216424,0.067386135,-0.037454296,0.02153547,-0.0012406418,0.00054007233,-0.026420906,-0.050084345,0.10622662,-0.012923531,-0.05990107,-0.01206995,-0.0797756,0.026874239,0.069511354,0.07484723,0.035233624,-0.06612102,-0.09050736,0.030890526,-0.021469403,0.016676143,-0.07655026,0.0041553457,-0.04385386,0.08212655,0.014348185,0.07431984,-0.050176464,0.050437443,-0.027401244,-0.019513972,0.0010104562,0.009350142,-0.03442149,0.004240625,0.009475161,-0.035508662,0.04653152,0.019191414,-0.000556157,0.09761228,0.024747504,-0.11011869,0.040078465,-0.044227906,0.037905354,0.07753155,0.06593548,0.09896155,0.04304207,0.039814975,-0.057474986,-0.04762294,-0.012980044,0.018371787,0.037355326,-0.02653741,0.0137997875,0.0060333083,-0.006564401,0.051138863,0.032069925,0.032569434,-0.02158814,-0.056459393,-0.09226252,0.024242252,-0.05091773,-0.08102474,-0.064601764,0.02930993,0.0053952504,0.041862104,0.038517814,-0.01935021,-0.04120323,0.023014277,0.05471399,-0.050548263,-0.032559194,-0.025769928,0.06713403,0.014607823,-0.030415982,-0.059412636,-0.012516812,-0.021017224,0.09087426,0.058936212,-0.050926313,-0.023118552,0.0033695635,-1.4921489e-33,0.036850046,0.009438145,0.038372934,0.045010522,-0.028474035,-0.068539195,-0.05247243,-0.10355318,-0.023391757,0.015142028,-0.09215426,0.01574671,-0.005162434,0.02658312,0.008171859,-0.02812819,0.046466783,-0.0049912143,0.011507215,-0.058507632,0.020531109,0.08616129,0.008807918,-0.016334739,0.006380459,-0.022684958,-0.042459827,0.047962468,0.07192013,-0.013138085,-0.010580814,-0.04108237,-0.060432404,0.053218216,-0.033572853,0.13696204,-0.112810075,-0.02920996,-0.025087751,0.05416131,0.0034968976,-0.03258353,-0.03178225,-0.03952354,0.026270235,-0.017893523,-0.06987272,0.071109995,0.027470468,0.011007189,0.02172085,0.015538596,0.0139720915,-0.011000987,-0.045680113,-0.07991181,0.03721824,-0.016305564,-0.02577477,0.1322079,-0.07467476,0.10342326,-0.025393689,-0.005589972,-0.04999043,-0.030255126,-0.045517653,-0.056598846,-0.007484827,0.01733567,-0.06875166,-0.011840274,0.14740331,-0.024416607,0.034972638,-0.057226792,0.010099431,-0.01926528,-0.003870239,0.027063502,0.0043421066,-0.096000634,-0.017458118,0.06507351,-0.06417693,0.04327492,-0.042161528,-0.027168898,0.029621914,0.023390122,-0.00630995,-0.070541166,-0.050501846,0.04793928,-0.008871683,-6.536836e-34,-0.027017985,-0.114745945,0.018415151,-0.013482016,-0.03862182,0.056460615,0.044756435,0.04224034,0.008791682,-0.07538596,0.055893272,-0.007289111,-0.104015194,-0.08187349,-0.056462888,0.04573795,0.042445935,0.059995823,0.0055405213,-0.038622223,-0.034209184,0.10270357,0.018602975,0.058883324,0.11550473,0.025714148,0.04351114,-0.011772383,0.015260666,0.11262765,0.051610112,0.055354636,-0.038850944,-0.03769178,-0.033483073,0.019093094,-0.029207416,-0.057733487,-0.025486141,-0.034152754,-0.051445745,0.01952558,0.12281754,0.0603371,0.09218939,0.1507691,-0.05316927,0.0065574404,-0.012200345,0.08009013,-0.0038943363,-0.05146375,-0.038788803,0.08531602,0.026472166,0.0047400827,-0.011485607,-0.002495034,-0.001812597,-0.024216162,-0.034628317,-0.042376515,-0.030312888,-0.08870365,0.04099028,0.0005276304,-0.0408343,0.052152287,0.021734439,0.023742069,0.090942495,-0.026105039,-0.027702063,0.037062597,0.02084292,-0.048342,-0.03578479,-0.05068153,0.020203814,0.05480441,-0.077420466,0.08924097,-0.026866745,0.032010183,0.02457094,-0.052916724,-0.012754393,0.046682492,0.0077967905,0.050207324,-0.025331102,-0.0022654594,-0.0343759,0.04247591,0.08835602,-1.7948281e-08,0.083111964,-0.09224773,0.012816,-0.049568363,-0.012649185,0.03837957,0.023697276,0.07285427,0.016248854,-0.027259812,-0.09356746,0.14145285,0.023195263,0.011631876,0.0019149627,0.00301503,-0.006275089,0.009318947,-0.028699877,-0.038371705,-0.10037235,0.018415954,-0.03595621,0.010933874,-0.0548558,-0.05947943,0.059278537,-0.020647598,0.013562686,0.036036745,0.0131122,-0.014278741,-0.009398016,-0.09582121,0.010186311,0.096506104,-0.018597284,-0.035688575,-0.06609754,0.018198997,-0.023855416,-0.055995114,0.05677169,0.027494965,-0.007933098,-0.054256704,-0.061671056,0.11169085,-0.02022306,0.0018241586,0.03080783,-0.023091579,-0.012013191,-0.065778024,-0.1011709,-0.021827992,0.036029674,-0.05455477,0.051889278,-0.09543868,-0.023020139,-0.032657184,0.21018429,0.0019088015 +3.2.1.23,Some enzymes in this group hydrolyse alpha-L-arabinosides; some animal enzymes also hydrolyse beta-D-fucosides and beta-D-glucosides; cf. EC 3.2.1.108 lactase. ,384,1.0,-0.004849026,-0.10422127,-0.033709444,-0.019991612,0.050271407,0.022215994,-0.05819466,-0.005363311,0.022121275,-0.011788359,0.01941013,0.0040495913,-0.07178052,0.014343276,-0.046926115,-0.02717136,-0.06610562,0.04186621,-0.054354407,-0.03237074,0.055799708,-0.013462795,-0.008222398,0.04984,0.07089536,-0.036222573,0.041970868,-0.047348592,-0.014091518,-0.0612778,-0.03040517,-0.07603804,0.100268774,-0.0075686174,0.0093280515,0.10009866,-0.0197016,-0.08587415,0.047376283,0.03436256,0.036544442,-0.06370212,0.07523603,-0.058678295,-0.036454022,0.007864809,-0.031860016,0.03934734,0.06893944,0.024619086,-0.03167544,-0.120569386,-0.041088898,0.017109958,-0.0055293525,-0.041392718,-0.025468556,-0.010911469,-0.018701816,0.059632014,0.013822512,0.05088534,0.024839135,0.05327603,-0.035243012,-0.0083722435,0.047623105,-0.054063585,-0.050349332,-0.06106207,-0.0092684645,-0.073912054,-0.007297596,-0.012776268,-0.022876373,0.03278775,-0.014166034,-0.06251414,0.024551699,-0.06870932,0.03295396,-0.029523639,0.030375484,0.06195546,-0.009902468,-0.034832224,-0.00254968,0.02946683,0.021187386,0.033939958,0.0079437075,-0.03288247,-0.019791692,0.0053788205,0.020643575,0.028802818,0.020070145,0.04066234,0.009780475,-0.06498526,-0.068104185,0.026425606,-0.025857816,-0.056913592,-0.067973144,0.055990625,-0.020103721,0.07741248,0.0074192644,-0.049223807,-0.06474981,0.036836397,0.033278227,0.033688422,-0.02395059,0.017178413,0.053934928,-0.10895016,-0.025752675,-0.014618308,0.01700202,-0.030576255,0.14377423,0.05366302,-0.016805448,0.05284305,-0.050053228,-1.8150451e-34,0.05265187,-0.01568893,0.009033065,-0.049901117,-0.0138461115,-0.019523742,-0.079696186,0.008323194,-0.04513253,0.0072675343,-0.032049693,0.001428103,0.025573127,0.0421751,0.027338285,0.0029001823,0.08982563,-0.06820658,0.013266945,-0.0024822883,0.018823186,0.027328275,-0.012291904,0.031152695,0.06041088,0.0068861605,0.009511214,0.043232042,0.051170383,0.020363063,-0.02807551,-0.15642841,-0.09775461,0.07610954,-0.04569128,0.06371422,-0.10776692,-0.042531453,-0.027325744,0.052379638,0.035706945,-0.04012216,0.026539419,-0.07542148,0.042925097,0.025117217,-0.034104355,0.075249046,0.033365086,0.051359147,0.019966416,0.03825875,0.011551533,-0.043047257,-0.027149973,0.00929898,-0.045404516,0.05378543,-0.051926427,0.12708235,0.005244797,0.10712023,-0.009973476,-0.013481665,-0.0328376,0.010942013,-0.047929823,-0.06812189,-0.016176226,0.0025720678,-0.062374912,-0.067311205,0.09806714,0.040721383,0.022420606,-0.038326096,0.042007044,-0.058211166,-0.042515706,0.0013182777,-0.04499411,-0.0019687861,0.00188792,0.06389681,-0.07691766,0.060012408,0.011593135,-0.043307234,-0.013579223,0.0004455214,-0.014717861,-0.020946385,-0.05213395,0.031084416,0.02735234,-2.1893816e-33,0.060437333,-0.092394516,-0.0028900674,-0.10567644,-0.049800124,0.027438672,0.06730289,0.018052172,0.055938896,-0.0005426233,0.011121669,-0.028556814,-0.05851577,-0.13067704,-0.024867304,-0.030719427,0.014683552,0.009890415,0.012029056,-0.025788717,0.035368662,0.13090345,0.06838297,0.051505502,0.09052956,0.01175253,-0.007550047,0.12866777,0.029876811,0.063912265,-0.007280021,0.0829671,0.015529075,-0.045976788,-0.06600811,0.020987388,-0.07378853,-0.04928757,0.04446377,0.019844351,0.020895012,0.07001434,0.080622375,0.020943334,0.055911638,0.14288597,-0.030661138,-0.014936176,-0.0078105563,-0.015727237,-0.008051124,-0.004881482,0.04978407,0.0706571,0.061860222,0.05434636,-0.00046788034,0.046659462,0.024632674,-0.038317826,0.0037369758,-0.026478738,0.045066215,-0.030782903,-0.010377596,-0.014734739,-0.05506301,-0.042511895,0.044658225,0.048591986,0.06131009,-0.022999022,-0.060700458,0.090374336,-0.00011726645,0.022516126,-0.1354026,-0.05240785,-0.0069190394,-0.04855596,0.015966505,0.057490107,-0.06468112,0.044497017,0.07030184,-0.08155237,-0.008454537,0.1416231,0.05817152,0.022864342,-0.066071264,-0.055442136,-0.08573969,0.058441386,0.05137301,-3.077794e-08,0.038065143,-0.07084233,0.05199786,-0.054517157,0.021404974,0.046834752,-0.028298374,0.0862492,0.0254605,-0.030418977,-0.06289055,0.0857936,-0.0022952538,0.011596706,-0.014987642,0.02328601,-0.007730561,-0.011737882,-0.007616221,0.012130051,-0.041994546,-0.02889435,-0.105185404,0.027029993,-0.0356011,-0.053329106,-0.008053549,0.032921,-0.04252581,0.014877195,0.016805673,0.024669778,0.028790534,-0.117201865,0.0046954392,0.06757726,-0.08808031,-0.049395256,-0.018738009,0.033081174,0.005566985,-0.08215894,0.011509622,0.017774746,0.016305435,-0.03692135,-0.02822871,0.008439341,0.024462577,0.0071981126,0.058090862,-0.059467405,-0.05601438,-0.0355561,-0.057391405,-0.010290736,0.0071546333,-0.11527645,0.023932114,-0.07039645,0.03784099,0.027370233,0.19082855,-0.058950048 +3.2.1.24,"Also hydrolyses alpha-D-lyxosides and heptopyranosides with the same configuration at C-2, C-3 and C-4 as mannose.",384,1.0,0.06171499,-0.06579934,-0.059131972,-0.08054715,0.037294455,0.040765535,-0.018036555,0.030225907,-0.020080566,0.046142086,0.0022726138,-0.009040406,-0.09825116,0.033309095,-0.017539412,0.020600306,-0.04577596,-0.015395376,-0.0060413177,0.0073142587,0.07908609,-0.08663723,0.038705405,0.043420933,0.0347705,0.020456975,-0.004677637,-0.03891998,-0.020839034,-0.10460272,-0.014281716,-0.06379789,-0.0035960025,-0.031387314,0.035125203,0.0678576,-0.043971874,-0.022462329,0.01715841,-0.015330533,-0.013660262,-0.02508088,0.055442087,0.04713629,-0.10350455,0.017250223,-0.13038859,0.09448129,0.022729393,0.05835519,0.002340951,-0.104743116,-0.017786097,0.021543026,-0.08191723,0.054639775,-0.11275832,0.040015414,0.06092694,0.028234849,0.012613564,0.05692452,0.055057816,0.053942136,-0.025901448,0.011225681,-0.0022699956,-0.017950378,0.00088513445,0.03354261,0.012195955,-0.06062595,-0.01758846,-0.015680972,0.06058405,0.047132056,0.035628755,-0.0827561,0.005525542,-0.040247366,0.009242565,0.0968854,0.041965857,0.089976005,-0.03859702,0.021390175,-0.043765765,-0.0003501236,0.055830352,-0.03638273,0.04849479,-0.020716349,0.010499937,-0.017822932,-0.010853246,0.037731584,0.08255034,0.049108174,0.006102742,-0.050045256,0.017924339,0.050362814,-0.0725802,-0.06220787,-0.029440004,0.06979019,-0.008063451,0.010180178,0.018593745,-0.00951837,-0.0032349878,0.017956527,-0.009438879,-0.07278487,-0.09880636,-0.0239368,0.0140456,-0.0024603757,0.0058003515,-0.05174905,0.027751451,-0.0100108115,0.05696729,-0.010034487,0.0071786814,0.013523502,-0.03698368,1.7923544e-34,0.04490909,-0.0056770197,0.057442635,0.0019782153,0.028534332,-0.03392546,-0.05885885,-0.05745746,-0.05598657,0.029667249,-0.16625461,-0.04417313,-0.03322484,0.0574693,-0.028801639,0.03312984,0.046938688,0.022168485,-0.007008269,-0.0065447898,-0.026332542,0.1027483,-0.014220521,-0.011337204,0.07091926,0.02764999,-0.008559734,0.08363247,0.08456933,-0.01012595,0.081317775,0.0066940333,-0.068601586,0.05999175,0.016998388,0.05608922,-0.11099928,-0.036755405,0.03313918,0.041201755,0.014128953,0.04103101,0.02141864,-0.06504361,0.01929544,-0.05421519,-0.005165062,-0.007963605,0.021472175,-0.046723276,0.045317475,0.015508596,0.022441385,0.025665825,-0.00044969097,-0.018529639,-0.0100481585,-0.010427733,0.027738491,0.07272497,-0.012820288,0.07073046,0.0031471502,-0.0525358,0.04580659,0.009567337,-0.023471374,0.0116467485,-0.06322644,-0.050448608,-0.068305455,-0.054197356,0.09725803,-0.0046234075,0.079774804,-0.02256728,-0.036136705,-0.04807999,-0.031721104,0.017652513,0.008867481,-0.07029913,-0.007274622,0.031122908,-0.043623142,-0.009414971,-0.024264479,-0.06072325,0.036677007,0.050480887,-0.04513287,-0.029941259,-0.06945224,0.020044366,-0.05287842,-2.8482913e-33,-0.0004395634,-0.080649294,0.029889353,-0.0040328135,-0.057268053,0.018928956,0.045379594,-0.0443444,0.0444719,-0.044563614,0.12154748,0.019109242,-0.14694588,-0.094758734,-0.015934754,0.031859674,0.044086266,0.06148746,0.0004491282,0.029186685,-0.0076671676,0.06556235,-0.038011163,0.0324975,0.090576954,-0.05925226,0.056418285,0.021795085,0.101808205,0.021411648,0.024037164,-0.002127703,0.021849327,-0.04564612,-0.004552538,-0.010549233,-0.06317797,0.014718766,0.013762573,0.034420405,-0.019729152,0.0014274662,0.05708766,0.0053501446,0.11535318,0.105395004,-0.09625474,0.040508743,-0.02595856,0.0439905,-0.035781294,-0.10751872,0.01119437,0.04885158,0.08743328,0.01869559,-0.02791231,0.01301755,0.031004088,-0.033060513,-0.010543482,-0.041803364,-0.0078008133,0.003692767,0.024422932,0.07378969,-0.1506811,0.027170178,-0.0034606648,0.008512422,-0.0014849438,-0.08177216,0.013677027,0.039509714,-0.015396875,-0.07099062,-0.07609837,-0.11063125,0.04445251,-0.04657784,-0.0045155054,0.041922428,0.027011232,-0.00010424371,0.037941106,-0.03792038,0.031683184,0.059603494,-0.007591786,0.089196704,0.0009031714,0.013694245,-0.014209079,0.04545699,0.08648099,-2.834203e-08,0.13491741,-0.01786836,0.050720613,-0.05669759,-0.03082249,-0.0233849,0.0039768596,0.02861702,0.00970016,-0.016193585,-0.045865398,0.1088868,0.05294794,-0.076660864,0.0085638305,-0.000356537,0.025431022,0.013914961,-0.04814885,0.020698566,-0.12080535,0.018906865,-0.045459628,-0.017939044,-0.0074466295,-0.025845824,0.11053564,0.01551433,-0.003679727,0.040757135,0.020681057,0.029945875,0.048948247,-0.11209331,0.007081716,0.030777024,-0.119532056,-0.023750521,0.064519696,-0.057209063,-0.016082063,-0.10020558,0.051207956,0.0016423296,-0.021306653,-0.031541966,-0.025824692,0.044197086,-0.019837856,0.018889764,-0.0041733137,-0.034022395,-0.047881644,-0.09535207,-0.037582856,-0.058995124,0.0027156412,-0.028113775,0.027723797,-0.14398605,0.012165836,-0.06437626,0.15808804,-0.008280481 +3.2.1.26,Substrates include sucrose; also catalyses fructotransferase reactions.,384,0.99999994,-0.014748107,-0.03090152,-0.106564015,0.035827015,0.06313672,0.042356003,-0.047630318,0.038445383,0.044885173,-0.014459476,0.01023883,-0.074186094,-0.07851734,0.026794577,-0.039204516,-0.022301171,-0.043838635,0.054594778,0.01848937,-0.026254017,0.12546527,-0.02346726,0.018758269,-0.024516331,0.038295884,-0.025713906,-0.056794323,-0.11532608,0.040078733,-0.05073788,-0.023683345,0.020861598,-0.0048528006,-0.0319834,0.052737985,0.10049377,-0.024223816,-0.061866626,0.029343672,-0.081960134,-0.010283896,-0.04490367,-0.0016242808,0.015329794,-0.0017906165,-0.043624777,0.023029264,-0.024891699,-0.036317103,-0.0336638,-0.009407534,-0.030441716,-0.08079418,0.025231453,0.027858207,0.050684005,-0.029057253,-0.055254802,0.021817984,0.058755495,-0.02822432,0.002967437,-0.09359086,-0.028512953,0.018994385,0.016080597,-0.035138775,0.002301074,-0.015182261,0.026230723,-0.053463947,-0.026016109,-0.02003207,0.04938066,0.08808248,0.019991811,-0.016563715,0.023659503,-0.021054346,0.015212687,0.06408342,0.023902114,0.020401947,0.033634774,0.04269032,-0.020910291,0.024358297,0.022813473,-0.01640482,0.053422347,-0.03958209,-0.001200964,-0.016771715,-0.020932898,-0.09802917,0.043202993,0.015450372,0.04032318,0.09973719,-0.03835746,0.014322873,0.043053076,0.024245923,-0.017360477,-0.09372301,0.027460882,-0.032436293,0.11586267,0.0062689795,0.011177168,0.009264535,0.021159371,0.023207145,0.017246393,-0.03815345,0.01700989,0.020226924,-0.11851561,-0.0032068398,-0.031422578,0.008321092,0.0652853,0.06882648,0.094028875,-0.04414883,0.019890828,-0.060475305,2.7639876e-33,0.07982516,0.009669399,0.007423233,-0.008951442,-0.034983303,-0.009580871,-0.05368239,0.009411635,0.0011422245,0.023694823,-0.05617334,-0.094531514,0.021001551,0.06114453,0.056504656,-0.076733045,0.0013825371,0.0037334277,0.06313562,0.015603271,-0.053745467,-0.0070232186,-0.0018798156,-0.028920704,-0.0094427075,0.019527053,-0.0916584,0.037349086,-0.024550343,-0.035555378,0.07264106,-0.025754727,0.011832379,0.014989924,0.06299824,0.01636751,-0.04812276,-0.012306499,-0.03949578,0.09489207,0.054599103,0.04951376,0.02606058,-0.025331149,0.08106114,-0.0012102111,-0.049534068,0.10177733,0.044667423,0.05793031,0.045034453,-0.0038689782,0.057081494,-0.02442685,0.0038921363,0.062174387,-0.027214518,-0.06621114,-0.029196447,0.017043341,-0.053642415,0.056164984,-0.060477354,0.01257852,-0.03681449,0.013118888,-0.08254326,-0.016394598,-0.06930668,0.072532125,-0.0778081,-0.0069165514,0.056611188,-0.01499189,0.10348724,-0.0076774037,-0.115117915,0.009248171,-0.020703504,0.040039983,0.0056744465,0.0269933,-0.08372504,-0.09815482,-0.07356228,-0.013947914,-0.0758492,-0.14357156,0.032389052,0.06939015,-0.079016626,-0.065398544,-0.0262768,-0.0038837905,0.011153053,-4.5595585e-33,0.09147645,-0.10482153,0.011514541,-0.085226946,-0.073351055,0.04231482,0.027560655,-0.0953547,0.057708405,0.027290639,-0.02064356,0.02880242,0.045397665,-0.037648298,-0.009948592,-0.020763183,-0.021985006,0.08119865,0.058074158,-0.034829445,-0.025988618,0.13560471,-0.038268223,0.055459414,0.10280117,0.003674265,-0.0076419585,0.10169959,0.08547529,0.011913718,0.005495498,-0.0948706,0.055944454,-0.035110313,-0.06725645,0.033589505,0.006427702,-0.0070897057,-0.020471651,0.00043248257,0.02236852,0.062405754,-0.011150127,0.08603756,0.015763244,0.07184968,-0.099696495,-0.0153167965,0.040683728,-0.051218074,0.04175342,-0.005323544,-0.07122905,-0.022768995,0.019850427,0.0532746,0.04280321,-0.037466694,0.049020987,-0.05417753,0.010158242,-0.056740247,0.0058609564,-0.0755071,0.080847844,0.042422622,0.0038411275,0.06677184,-0.025566375,0.026963651,0.08959837,0.025893604,-0.05150981,0.017471004,0.025929298,-0.047450416,-0.11988384,-0.043272328,-0.047012955,0.0155893415,0.009538205,0.013584813,-0.02117686,-0.0652629,0.021911003,-0.071614094,-0.019008506,0.038003244,-0.00048373526,0.025929695,-0.040265273,-0.0031455064,0.004629252,0.026569182,0.052745584,-2.4679451e-08,0.012002641,-0.02239726,-0.010948385,-0.03701468,-0.05190164,0.061181493,0.026692672,-0.009760168,-0.030972231,-0.03847779,-0.088652946,0.08660268,0.030045347,0.017360238,0.07585971,-0.00929548,0.016963612,-0.022815103,-0.029273326,-0.01702918,-0.079927444,0.008733729,-0.07137425,0.08419915,-0.011017045,-0.10794613,0.07678233,0.07532306,0.026150677,-0.04633145,0.032484017,0.023192545,0.057095762,-0.037497297,0.008791307,0.012371732,-0.0092325155,-0.079112336,0.021135945,0.064376615,-0.0063309134,0.01310984,-0.044414144,0.020616889,-0.05436385,0.003985744,0.011185394,0.057171114,-0.023841428,0.048735842,0.04194283,-0.05258895,-0.062012285,-0.013601299,-0.024661927,-0.0485081,0.017578518,-0.015161227,0.02792068,-0.009123794,0.08709145,0.04025226,0.25645456,-0.045232948 +3.2.1.28,"The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha-trehalose, releasing initially equimolar amounts of alpha- and beta-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.",384,1.0,-0.038691495,-0.042737734,-0.12731458,0.05621065,-0.004688559,-0.0020971093,0.007354539,0.012776073,0.05104568,0.045010857,0.034472574,0.040315673,-0.105473466,0.0652858,-0.11177566,0.034757107,-0.059302546,-0.023466272,-0.026341233,-0.12341467,0.06650901,0.02129451,-0.04032397,-0.007224214,0.08151044,-0.1100229,-0.011772334,-0.09717432,-0.01438131,-0.03719531,-0.012478682,-0.047439538,0.07784479,0.005301408,0.015710255,0.123128586,-0.032229993,-0.07137489,0.03884575,0.016951654,0.028989764,-0.044341832,-0.021574495,-0.0007527142,-0.09761119,-0.007132714,-0.060393702,0.060361434,0.0077932053,0.039678082,0.0064188,-0.029780626,-0.097843505,-0.044537745,0.015511073,0.07142235,-0.01145792,-0.052983765,-0.049987283,0.03670546,0.1018723,0.013015242,-0.06993726,0.052080013,-0.031821728,-0.10557412,0.0705006,-0.05167277,-0.057501454,-0.064753085,-0.03257724,-0.08353116,-0.00027214648,-0.017330628,0.014498169,-0.038261443,-0.062571295,-0.012874309,0.0494706,0.051174033,0.12890263,0.0010417904,0.056956526,0.084777325,0.05188273,-0.038696647,0.05438138,0.03927158,0.07654301,0.037805874,-0.022113558,-0.057688627,-0.0046081943,0.010964371,-0.03458953,0.02967515,0.012196904,-0.068465814,0.019810583,-0.012223673,-0.025363922,0.028553132,0.07413058,-0.052309718,-0.092811204,0.05392976,-0.027310863,0.099012196,0.08634692,0.02054056,-0.007473349,0.07119393,0.08059911,0.0312286,-0.023978775,0.067351006,0.0057055946,-0.038296983,0.014397558,0.0044971993,0.032636613,0.03443441,0.008919521,0.07880409,-0.017287798,0.09398139,-0.049922336,8.094586e-34,0.08190787,0.07032129,0.0036747372,-0.04510637,-0.027580328,0.01237289,-0.09374552,0.00797252,-0.034530498,0.04729298,-0.08685868,-0.055262525,0.020314557,0.08967526,0.031730015,-0.004518113,0.016991248,0.038614012,0.040785424,0.015030282,-0.037420552,0.06830365,-0.07508001,0.004898364,0.03204274,0.058570895,-0.07008477,0.036830146,0.04284602,-0.007812863,0.042074624,-0.047771975,-0.07358464,0.027908243,0.06453554,0.011389602,-0.017554203,-0.030997075,0.015049948,0.049965527,0.0019488289,-0.0023929775,0.010934134,-0.08419856,0.033148337,-0.050885588,-0.04738654,0.02553869,0.009117456,0.08254555,0.018390305,-0.023395807,0.049571924,0.052368272,-0.039742593,0.052404933,-0.029101754,-0.01112083,0.02423937,0.025237404,-0.015337184,0.03902542,-0.044335455,-0.033174302,-0.02594926,-0.02831343,-0.026518155,-0.07564116,-0.069176584,0.067301035,-0.092764266,0.010911723,0.013031409,-0.012119585,0.008128563,-0.05445339,-0.023869136,0.02340174,0.00444688,-0.041447926,-0.03754501,0.004492422,0.048465077,-0.013845407,-0.078156516,0.017212782,-0.0022004242,-0.025551163,-0.017782036,-0.008697623,-0.028999867,-0.02111433,-0.07056795,0.03630351,0.0725255,-2.6263997e-33,0.10339496,-0.1351133,0.015472754,-0.08431149,-0.03677241,0.027824301,0.026142394,-0.046525553,-0.0050259074,-0.038011316,-0.010608942,0.046653092,-0.0005779999,-0.04922086,0.06547273,-0.03206483,-0.0009542997,0.07154201,-0.052082796,-0.0145748025,-0.025235541,0.104337834,0.05542375,-0.034332752,0.0820208,-0.032745387,0.035349637,0.06436748,0.016821178,0.051555168,-0.0073211235,-0.054177627,0.046964247,-0.05285722,-0.014425879,0.090048626,-0.03491627,-0.029902028,0.010612828,0.017116789,0.043494977,0.050625447,0.03217698,0.03461743,0.09396686,0.083173156,-0.10601581,0.002683677,-0.025541341,-0.071338795,0.018350089,0.026359882,0.020379448,-0.015630916,0.012404569,0.021536816,-0.0024560152,-0.01295583,-0.06203753,-0.028291926,-0.0412926,-0.020604746,0.054820016,-0.00095702836,0.031431675,0.024861306,-0.023216644,0.017824471,0.022330152,0.046513926,0.007064599,-0.0018281724,-0.06426496,0.07217331,0.0064059845,-0.09019024,-0.10464983,-0.036712576,0.015791481,-0.027022429,-0.025109312,0.048799496,0.026342958,-0.06792601,-0.018699612,-0.13875929,0.022341782,0.12563105,0.04412006,0.052999225,-0.06543969,0.006599093,-0.030154867,0.008845642,0.09314218,-4.1914852e-08,0.044201333,-0.015577846,0.010423815,-0.05248578,-0.01967029,0.037204746,0.063467614,-0.010481713,0.04544093,-0.053367708,-0.039596267,0.11640248,-0.016069498,0.060286228,0.020129198,0.019907773,-0.028855136,-0.024647644,-0.024964642,0.01763771,-0.07313032,-0.003466872,-0.07653014,0.02366225,0.011755059,-0.099420115,0.026369445,0.05857001,-0.033767954,0.019626906,-0.01550163,0.07423894,0.032656662,-0.010165631,-0.0705501,0.08651202,0.0058316183,-0.015491148,0.013706748,0.004057707,0.022238169,-0.020743709,-0.03528689,0.011576737,-0.048222706,0.024945967,0.010848272,-0.039793685,0.022925928,0.04670875,0.010718158,0.006317968,-0.07260491,-0.043250863,-0.09720694,-0.05768633,-0.039575364,-0.043718807,-0.015738826,-0.076357864,0.038621094,0.024345923,0.1585516,-0.073744714 +3.2.1.32,"This enzyme is found mostly in marine bacteria, which break down the beta(1,3)-xylan found in the cell wall of some green and red algae. The enzyme produces mainly xylobiose, xylotriose and xylotetraose.",384,0.99999994,-0.043918494,-0.06369559,-0.11819005,-0.019679409,0.06442216,0.045437343,-0.007044478,-0.0072209784,0.039255932,-0.0062058163,0.068096384,-0.08829027,-0.03854124,0.04660955,0.00039592342,0.09131465,-0.051604073,-0.045234345,-0.011183392,-0.0073672747,0.04614454,0.06541226,-0.006943827,0.015723053,0.016134081,-0.03879688,0.020417875,-0.09919522,-0.019405842,-0.054371424,-0.03193898,-0.03747421,0.101136506,-0.085486606,0.121899255,0.048208393,-0.04825512,-0.14892694,0.04310524,0.021539694,0.005786948,-0.020907657,0.06683687,6.7556575e-05,-0.06389543,-0.00043881364,0.05028163,0.042269487,0.06495346,0.019614602,-0.052284405,-0.08324018,-0.048987556,0.018286658,0.0745703,-0.001188939,-0.016285358,-0.031006394,-0.05299609,0.018031469,0.10131398,0.07292357,0.0392601,-0.0074817245,-0.057420217,-0.025678812,-0.03631019,-0.06802128,-0.0058722985,-0.052525196,-0.05632182,-0.05199125,0.018038228,0.040698268,-0.037368353,-0.01978499,0.10703273,-0.05960262,0.012308755,-0.0051101483,0.0053479,0.022274278,0.040455498,0.052305598,0.009235501,-0.03425041,0.01927376,0.07242212,0.0012971569,0.07542729,0.033563737,0.06354035,-0.029595407,-0.116728075,-0.029864712,-0.0028697073,0.069808096,-0.007246926,0.087253876,-0.036205173,0.0025264393,-0.014526092,0.08368943,-0.06395334,-0.104841165,0.021669073,-0.009376285,0.10519787,-0.030028839,0.010356416,-0.0376302,0.0047891703,0.012469697,0.0239942,0.0009865046,0.09998656,0.07872794,-0.05825808,-0.10930868,0.042505246,-0.014992851,-0.08918991,0.08303955,0.0980637,-0.03358473,0.082968034,-0.14017254,1.0312313e-34,0.05109699,0.034196597,-0.04582718,-0.071849555,0.0007692422,-0.01179134,0.023201076,0.012229266,-0.045564514,-0.03631653,-0.06163068,-0.033357587,0.025484657,0.039758377,-0.011405838,-0.012019601,-0.0042368146,-0.03422894,-0.024778973,0.0424743,0.017725809,-0.015338666,-0.02646424,-0.055685963,-0.012671116,0.03703868,0.025973743,-0.0072122402,0.019930743,-0.02059465,0.012946498,-0.11261356,-0.036025707,0.06119305,0.082605295,0.05939877,-0.043052204,-0.03156714,-0.052193772,0.06317938,0.034124285,0.014824954,0.022244059,-0.05106916,0.090250514,-0.053905793,-0.076773725,-0.0016150028,0.07672628,0.023099298,0.031211812,0.002327519,0.042112906,0.046367723,-0.011577887,0.056581523,-0.013565823,0.04287868,-0.0023323637,-0.009395277,-0.048878185,0.009886631,-0.02509193,0.013777058,0.02601595,0.04281683,-0.006461011,-0.0380367,-0.019898804,0.016831245,-0.07582498,-0.072085574,0.07526046,-0.017698633,0.04796146,-0.05781538,-0.09131643,0.049163096,0.027279897,-0.04718191,0.040459897,-0.015219913,0.0339717,-0.05625026,-0.07931098,0.019740412,0.01034309,0.017055867,0.0034500451,0.070719436,0.045399833,-0.11970096,-0.0514023,-0.0142844515,-0.008358811,-1.4975527e-33,0.05734473,-0.1179377,0.05414247,-0.07817432,-0.023917079,0.030554788,-0.0129416445,-0.0070013287,0.010643992,0.020858092,0.028279437,0.07646955,0.0005716917,-0.026974954,0.043322705,0.031176655,0.085900955,0.06441275,-0.008569478,-0.07139317,-0.0022415952,0.012440039,0.0567502,-0.015510214,-0.0059498018,0.006651495,-0.008769766,0.047730148,0.047459293,-0.010466923,-0.11513424,0.040292997,0.024983611,-0.06320421,-0.042341713,-0.034518935,-0.12083773,0.005323085,0.04597073,0.06613076,0.03861375,0.0037228707,0.02521246,0.07137534,-0.015479217,0.10785021,-0.03712681,0.0047142957,-0.012745878,-0.004575723,0.0048882244,-0.01920296,0.015866186,-0.019274589,-0.003810053,0.08625173,-0.022190373,0.09418032,-0.0060263583,0.02649913,-0.048163164,-0.05694806,0.07335882,0.0019987952,0.051596455,0.024116702,0.016850086,0.06186487,-0.009805686,0.038217165,0.060398903,0.019124797,-0.057180613,0.06937714,-0.04792405,0.0119674485,-0.13391621,-0.07524404,0.017341765,-0.007455614,0.07766773,0.011354136,0.011005143,-0.058224265,0.039273847,-0.03397828,0.05584813,0.11401244,0.014858881,-0.064265996,-0.012593933,0.007721407,-0.084437355,-0.021845823,0.13850391,-2.9316102e-08,-0.005607205,-0.03814123,0.02219766,-0.025395032,-0.010727949,0.037683956,0.063721515,0.044347808,0.055642173,-0.013947884,-0.039744847,0.04232703,-0.028519658,-0.028796121,0.0119609665,-0.032087553,0.0011591108,-0.04018968,-0.020690449,-0.022380201,-0.028699948,0.02211812,-0.044580575,0.0141775375,-0.064760156,-0.045666464,-0.00057358097,0.037040383,-0.014912738,-0.034490734,-0.051013846,0.042490404,-0.023142358,0.007408719,-0.076320305,0.047413316,-0.035375506,-0.08289686,-0.037766464,0.010787879,-0.0022146096,-0.055561725,-0.030314365,-0.022475554,-0.024097998,0.06446994,0.015785689,0.0071158423,0.013365212,-0.056070663,0.013977302,-0.03546853,-0.07016046,-0.09198771,-0.06327843,0.062044404,0.010307399,-0.02633138,-0.03429631,0.01435222,-0.026245112,0.0016382004,0.18489207,-0.0111701945 +3.2.1.33,"This enzyme hydrolyses an unsubstituted glucose unit linked by an alpha(1->6) bond to an alpha(1->4) glucose chain. The enzyme activity found in mammals and yeast is in a polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25 (4-alpha-glucanotransferase), which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyse. Together, these two activities constitute the glycogen debranching system.",384,1.0,-0.020714626,-0.06369473,-0.09343721,0.020278033,0.02236159,-0.002622965,-0.022106517,0.05394016,0.028536808,-0.052113783,0.0012237078,0.090097986,-0.12543543,0.01050689,-0.07229063,-0.03671332,-0.07913348,-0.006916277,-0.018124275,-0.010201887,0.11046077,-0.004949574,0.003089186,0.014745841,0.0318079,-0.047795013,0.06353143,-0.0765144,0.01992563,-0.061395098,0.0019186198,-0.07791952,0.08554203,0.038071573,-0.012862262,0.1210952,0.0049033966,-0.087886944,-0.02105475,-0.012380145,0.06330879,-0.036712542,0.00460308,-0.031031733,-0.05705448,0.006636232,-0.066949196,0.006577615,0.02198367,0.07262561,0.022827204,-0.1082595,-0.0559364,-0.0030334436,0.024772998,0.06585809,-0.08918948,0.0038714807,0.0036862732,0.013837239,0.04020028,0.049631536,-0.053406518,0.07370108,-0.016110746,-0.08551548,0.13640212,-0.024607671,-0.04637562,-0.06021832,-0.0471289,-0.014129145,0.022241639,-0.022056244,0.005667777,0.037934598,-0.049763963,-0.053033832,0.033892106,-0.03652076,0.07093361,0.022183284,0.08408315,0.09019283,-0.027203552,-0.016762115,0.0242932,0.0018782286,0.032317955,0.033340853,-0.016919672,-0.03636346,-0.03477852,-0.025752092,-0.01850127,0.04462358,0.041754294,0.00464558,0.010028266,-0.009552943,-0.004494224,0.08270023,0.06655115,-0.03890449,-0.050345737,0.059392635,-0.013829596,0.07001914,0.08046895,0.026590317,-0.029292647,0.020029118,0.05910931,0.011809067,-0.03891895,0.023289239,-0.018398857,-0.01778004,-0.02063799,-0.022871789,0.045050412,-0.013586403,0.069911025,-0.0140598975,-0.044165567,0.035623718,-0.039117694,1.5587086e-33,0.08617249,-0.0393453,0.0025650724,-0.005097079,-0.008000664,0.026989007,-0.0654829,-0.032726478,-0.06107582,0.03476641,-0.045191497,0.010916319,0.011609298,0.13092133,-0.0027048464,-0.04299809,0.04727395,-0.005472102,0.09602349,0.02902513,0.027750019,0.05659866,0.009573004,-0.026828608,0.04902741,0.01454753,-0.054390974,0.04207164,0.008357142,0.0035033352,0.017596327,-0.034656543,-0.0879672,0.07023191,0.06540584,0.00924843,-0.007628017,-0.067834705,0.03325554,0.04655279,0.007195618,-0.013797585,0.014409457,-0.109152146,0.049269814,0.0013492716,-0.015090466,0.04045721,0.004635905,0.11029753,-0.0034659293,-0.035951294,0.06542232,0.033740357,-0.029721271,0.026867276,-0.04156712,-0.027352793,-0.023038363,0.058161683,0.038645606,0.119509116,-0.02770153,-0.0060182717,-0.02387289,0.04609371,-0.101937525,-0.06702679,-0.022806335,0.045150727,-0.050817285,-0.011662518,0.03847998,0.00778174,0.022705704,-0.0715038,-0.0038779234,0.049397748,-0.057675958,-0.018788235,-0.003977546,0.00774951,-0.008069963,0.018416945,-0.067126065,0.06776664,0.005935436,-0.015753658,-0.06957765,0.015100172,-0.009840772,-0.0600085,-0.022139769,0.041163288,0.032121655,-4.2335414e-33,0.135319,-0.114053324,0.07203445,-0.074601814,-0.032020293,0.06465039,0.07151057,-0.069699176,-0.03763943,-0.054035727,0.027672738,0.056284513,0.01525543,-0.05950492,0.04079915,0.006202855,-0.057594746,0.0591744,-0.06561382,-0.032900423,0.01609946,0.086002216,-0.014016678,0.056437045,0.11956284,-0.052699223,0.02640706,0.09319643,0.0024984705,-0.0052369675,-0.037301317,-0.018884238,0.0048448537,-0.051637717,-0.048266336,0.054661416,-0.057878263,-0.012367401,-0.03307995,-0.04188284,0.031495184,0.09176516,0.019438418,0.024592629,0.09409985,0.092344455,-0.05439752,0.021683807,-0.04174961,-0.03336359,-0.023456017,-0.009893144,-0.046693098,0.0551246,0.052638747,0.064170875,0.01852262,0.008838387,-0.03626791,-0.05977287,-0.0333351,-0.03825687,0.015262949,0.0016205165,0.034474712,-0.013769158,0.020610495,-0.017231595,0.03859164,0.09883589,0.041875076,-0.078764334,-0.012219644,0.016063713,0.009276734,-0.044568926,-0.10303462,-0.105523296,-0.0023660236,-0.07755285,-0.006768646,0.010987795,-0.0028062572,-0.09371253,0.057706963,-0.106150694,0.06744541,0.10823427,0.03707296,0.032293025,-0.008801609,-0.0063345274,-0.06394101,-0.0056337877,0.05119203,-4.5407557e-08,0.0552698,-0.05953285,-0.00016541574,-0.055948403,0.006900197,0.009410552,0.0570227,0.036410183,-0.025092848,-0.022306891,0.0065376856,0.09400559,-0.0414944,-0.0010370115,0.0014089707,-0.014219763,-0.062286656,0.057790525,-0.05199876,-0.0042887037,-0.110359125,-0.037713025,-0.14704145,0.069303215,-0.015203413,-0.08628473,0.032881476,0.08737433,-0.01749353,-0.0016534287,-0.0034900056,0.06871551,-0.010821184,-0.07870643,-0.06819496,0.04885589,-0.02453892,0.024091465,-0.007464845,0.008312871,0.013926489,-0.08507986,0.028974572,0.027275635,-0.048973333,0.024933515,0.0035020327,-0.009907153,0.008586526,0.04375004,0.01902123,-0.0038819744,-0.07331358,-0.026830792,-0.07714037,-0.047075585,-0.06333994,-0.067031465,-0.012949236,-0.044692323,-0.00039138424,-0.008163451,0.15052763,-0.07895047 +3.2.1.35,"Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.",384,0.99999994,-0.019921776,-0.1635917,-0.05279903,0.02836151,-0.019369768,0.032143004,-0.025475184,0.035903808,-0.037351735,0.013520664,0.006019343,0.11034357,-0.017192457,0.02932936,-0.13451363,-0.005173254,0.028346134,0.0054035275,0.03082769,0.03897191,0.046370126,-0.0777182,-0.021506794,-0.00013527108,0.0009318336,0.018350588,0.03950595,-0.010490918,-0.04731255,-0.06399667,-0.07491023,-0.01308886,0.029324275,0.015222644,0.0025299846,0.021346368,0.024858298,-0.012508907,0.00070053985,-0.00062696345,0.006189756,0.00066784146,0.056407675,-0.020711284,0.062370505,-0.13003555,-0.03633468,-0.0030423445,0.07857276,0.06739867,0.0706422,0.022491274,-0.017870983,0.013571075,0.024573656,0.021799926,-0.0952615,-0.047855802,0.05829936,0.07339572,0.07121558,0.050985795,-0.021310003,-0.06965182,-0.004962052,-0.05540005,0.10463639,0.008368346,-0.058918536,0.05079591,-0.030477313,0.02819507,-0.007279183,-0.029588973,0.030029792,0.0692082,-0.063348435,-0.0242892,0.038556736,-0.0861663,0.021547455,0.04058902,-0.0041310634,0.123050414,4.5004745e-05,-0.038034305,0.04958414,0.011395552,0.046960566,0.004693612,-0.018161306,-0.051975638,0.007701694,-0.07117402,-0.028189888,-0.058410153,0.0055857087,0.019489579,-0.00849818,-0.0008217325,-0.018848551,-0.044166762,0.022796452,-0.07153027,-0.0059515135,0.060199063,-0.004582263,0.08454898,0.10615731,0.025955664,-0.06877531,0.030279173,-0.034125634,-0.0010786974,-0.08583838,0.044409573,-0.0053477464,-0.039546516,-0.04428742,0.0038052779,0.029365858,0.022433978,0.042615376,0.02930619,-0.001815485,-0.016069546,0.05968676,2.960472e-33,0.10623685,0.034275454,0.09267024,-0.022234328,0.0022726206,0.019634033,-0.08277271,-0.041412774,0.031405345,0.021584712,-0.032185968,0.12357845,0.04235194,0.048353657,-0.018460434,0.14703658,0.044111595,-0.06488809,0.06085894,-0.041544434,-0.011430031,0.08489245,-0.105482206,-0.032482874,0.051418524,-0.048591267,-0.03742135,0.052220855,0.07073492,0.0014564072,0.0255988,-0.05728886,0.03365163,0.0082025975,0.033570398,0.04956541,-0.012664826,-0.053514626,0.072454706,-0.04265237,0.09062092,-0.05944411,0.011246652,-0.020457592,-0.04561096,-0.037869193,0.028444005,-0.014116627,-0.05208973,0.057824362,0.0024201355,-0.02627422,0.01679958,0.025118899,-0.04370301,0.035478406,-0.053108744,-0.031705573,0.03214721,0.10097517,0.032618668,-0.018838247,-0.030713698,-0.07159672,0.004897648,0.0038837616,-0.040242147,0.015456621,-0.021902999,-0.051804967,-0.099964514,-0.041430075,0.044732373,0.08541535,-0.032148506,-0.03873661,0.02687603,0.08220262,-0.01700848,-0.041897435,-0.06337006,0.005514871,-0.021725196,0.007410736,-0.03588421,0.116187245,-0.039311975,-0.06711437,0.006577704,0.019055372,-0.058038026,-0.07053088,-0.034426384,0.042589203,-0.047826715,-4.7194107e-33,0.0024426228,-0.060172506,0.037812266,-0.012466928,-0.0076720887,0.013356958,0.061822694,0.008597587,-0.025057819,-0.041170146,0.063757315,0.0035668742,-0.009604185,-0.061968558,0.016619204,0.04787861,-0.020542962,0.022416368,0.0012796847,0.010704531,-0.04115848,0.07649872,0.034770224,0.031823024,0.035942063,-0.007489003,0.06059176,-0.027784787,-0.007814093,0.15213197,-0.016504291,-0.046282988,-0.057282005,-0.082276575,-0.05812204,-0.027354237,-0.06520126,-0.05431556,-0.019440463,-0.00819987,-0.030229688,0.031012597,0.058687214,0.042553075,0.1158332,0.08133266,-0.056487616,0.03083825,0.0025845228,-0.00090245425,0.06120129,-0.008572193,-0.013607626,0.04843925,0.05314151,0.061281886,0.0015038109,0.03705012,0.044166766,0.012973143,-0.060350273,0.011483094,-0.011460401,-0.11519242,0.026691409,0.04639101,-0.05050094,-0.011632859,0.012667422,-0.057678208,-0.029372511,-0.028601129,0.057993665,0.081591256,0.028670667,-0.032861527,-0.07372408,-0.085270435,-0.046092354,-0.03093174,0.016027454,0.0387701,-0.025803696,-0.067762546,-0.023923857,0.028021203,0.042349868,0.10848555,0.056356955,0.066594355,-0.005003191,-0.01401868,-0.045988888,-0.0029755954,-0.03135813,-3.4129407e-08,0.102375716,0.023909697,0.03852872,-0.052644853,-0.0891361,0.015115826,0.0355456,0.033827137,0.006763188,-0.05598235,-0.0029334158,0.11395025,-0.034948792,-0.00286725,-0.07741348,0.07825605,0.006147286,-0.015282709,-0.040832832,0.024475122,-0.10440512,0.0031515022,-0.036905687,0.08509675,-0.013645049,-0.043752667,0.046664253,-0.015408402,-0.06963109,-0.009298175,0.066961214,0.01642159,-0.08124682,-0.09321107,-0.023725433,0.02017875,8.8935485e-05,-0.004753953,0.07335327,0.019144377,-0.0043843747,0.010404502,-0.04383977,0.042160656,-0.020999838,-0.038198393,0.0055657253,0.022812234,-0.043404907,0.06001146,-0.04536172,-0.06467472,-0.07938994,-0.1392513,-0.04020659,-0.07354592,0.053156707,-0.07111836,0.011180585,-0.012882439,-0.081981145,-0.07647185,0.12633349,0.034996018 +3.2.1.37,Also hydrolyses xylobiose. Some other exoglycosidase activities have been found associated with this enzyme in sheep liver.,384,1.0,0.042010706,-0.07965376,-0.07480481,0.05623945,0.072801456,0.006986395,0.0053800615,0.038712364,-0.022273004,0.00390882,0.05354778,-0.019731043,-0.039211318,0.0845072,-0.06685856,0.079057,-0.058287196,-0.018568624,-0.024749454,-0.01624458,0.044343486,-0.014960784,0.012815522,-0.035637252,0.050197,-0.042683605,0.029286742,-0.07231055,-0.017825214,-0.049949702,0.008012343,-0.05616756,0.07497669,-0.07158834,0.024686942,0.086291574,0.04401805,-0.029868605,0.040074654,-0.05123153,-0.00048688863,-0.027383108,0.033514548,-0.09183592,-0.09984622,-0.020903632,0.0154689,-0.0021008146,0.046309426,0.06806546,-0.050745457,-0.11248751,0.0053852694,-0.010282859,0.026110679,-0.014901058,-0.04314043,-0.057650138,-0.045106735,-0.018573351,0.010620907,0.070285246,0.06723086,0.048876833,-0.037571747,0.009241477,-0.010717573,0.014265999,-0.044811882,-0.03388383,-0.038415957,-0.07843868,0.013872566,0.020115469,-0.07694549,0.025855226,0.009064524,-0.054588657,0.07461458,0.0033000985,-0.024239175,0.01050575,0.05651581,0.05685797,-0.0099617485,-0.0018843337,-0.030218482,0.0018951372,-0.017829183,0.016116552,0.02062759,-0.04375977,-0.013465402,-0.024982763,0.034114704,-0.047766414,0.09158998,-0.0082335025,-0.026200213,-0.03662442,-0.03405464,-0.0068306853,0.029878322,-0.06181385,-0.029859044,0.04495363,-0.019991538,0.08783096,0.05412111,-0.032878917,-0.10561317,-0.009289752,0.031667978,0.03594899,0.010094035,0.06417051,0.08539465,-0.016180078,-0.10392342,0.037035614,0.030422386,0.025241908,0.12629628,0.017799724,0.039467964,0.039893556,0.003455175,-3.6655087e-34,0.0729262,0.01062881,-0.010426883,-0.052333344,0.052719653,0.0021249917,0.018956376,0.09051286,0.020332055,-0.0070336647,-0.025187602,-0.005523012,0.055447232,0.017563011,-0.020878747,0.011366524,-0.013147154,-0.0013874073,0.08382319,0.0054350775,-0.009169673,-0.014143965,-0.003689807,-0.032213315,0.006697038,0.056851853,0.0020384933,0.01590285,0.02259596,0.015944978,-0.0135905035,-0.07150524,-0.098397575,0.041935652,0.0031421215,0.08686242,-0.0049460027,-0.06548927,-0.015695494,0.04121671,0.021869734,-0.06296171,0.02250385,-0.12768616,0.040540207,-0.050969154,-0.13006221,0.052124716,0.060186956,0.016428055,0.08381118,-0.017670987,0.037845936,0.016059225,0.024379179,-0.020508762,0.0042183865,0.04851274,-0.01553541,0.083764456,0.036289573,0.033953734,-0.025714397,-0.015659733,-0.013781207,-0.056695852,-0.05257779,-0.059524238,-0.119594894,0.042438783,-0.0634664,-0.057206564,0.109998316,-0.015498879,0.010927676,-0.09229719,-0.028962605,0.022352213,0.009910464,-0.00022819595,0.026050348,-0.023036053,0.050086036,-0.004161904,-0.038880803,0.07482189,-0.037916254,0.0008774768,-0.06529042,0.072331704,0.043271523,-0.037272353,-0.1552785,-0.027417675,0.02651536,-2.1158513e-33,0.03753999,-0.03777581,0.032272253,-0.045951314,-0.014123745,0.03252837,0.030341722,0.05366005,0.057140987,-0.030860709,0.062307898,-0.0026830302,-0.02585937,-0.072656475,0.03167769,0.03144727,0.037563004,0.06189225,0.04755945,-0.12575583,-0.024392411,0.07463401,0.006770172,-0.0290619,0.08658317,-0.025773274,-0.030975007,0.03731348,-0.046169035,0.01622012,-0.026804348,0.05526948,-0.020721324,-0.050276387,0.019483661,-0.009836419,-0.1079632,-0.05139552,0.025033388,0.0014377027,-0.013120824,0.038178355,0.07881481,0.12324815,0.04503386,0.12913126,-0.15051502,-0.08106985,0.06559421,0.04438941,0.04034867,0.0074759275,-0.038437057,0.0281364,0.008555487,0.0832722,-0.07414871,0.037803233,0.005517656,-0.037800603,-0.038885385,0.006851201,-0.0022292796,-0.009736094,0.0641501,-0.014375604,-0.043361098,0.026414158,0.027640006,-0.039937496,0.08014899,-0.09356136,-0.11800588,0.07952626,-0.055715837,0.046001058,-0.057375774,-0.055782165,-0.0012209417,-0.03960938,0.026070785,0.037429195,0.071239054,-0.0308812,0.0626362,-0.05910099,-0.06000069,0.13492148,0.040166255,-0.008683777,-0.0011411905,-0.007884841,-0.104320206,-0.00785764,0.084755495,-2.2699776e-08,-0.05165967,-0.100802995,-0.022382319,-0.018526154,-0.02005829,0.045300357,-0.021548936,0.037084784,0.017779676,-0.05090389,0.0151062505,0.05809662,-0.03734103,0.030623201,0.013181532,-0.021009754,-0.023258172,0.017050225,-0.02423282,0.003548527,-0.10458469,-0.027749723,-0.059099413,0.045586783,-0.045598123,-0.07256616,0.027596503,0.06799247,0.043764774,-0.020455038,-0.0704463,0.023587361,0.007739513,-0.0016941713,-0.048110962,0.054764375,-0.0299539,-0.06925246,-0.06325586,0.0006682779,-0.01692666,-0.06713504,-0.0002487846,-0.026199248,0.023431374,0.007252793,-0.034974966,0.029681519,0.008695357,-0.077263094,-0.029277897,0.0042704293,0.018527523,-0.037039023,-0.056396455,0.043167807,0.027582102,-0.048408817,0.009001421,-0.048781354,0.015931303,0.0550633,0.20075819,0.01954562 +3.2.1.38,"Enzymes from some sources also hydrolyse beta-D-galactosides and/or beta-D-glucosides and/or alpha-L-arabinosides. The activity of EC 3.2.1.37 xylan 1,4-beta-xylosidase, is an associated activity found in some sources (e.g. liver).",384,1.0,0.019606752,-0.11649461,-0.036680687,-0.031651866,0.059199423,0.03372925,0.00013804022,0.010168318,0.022269499,0.0043545617,0.07428733,0.008805148,-0.064595565,0.058979284,-0.0006233294,0.021882985,-0.034032296,0.009075777,-0.015644938,-0.036430925,0.040736403,0.005689267,0.020486828,0.05155836,0.052909702,-0.011566165,0.058366466,-0.09153077,-0.008545074,-0.050538976,0.014391482,-0.06387801,0.12892272,-0.053362686,0.0073967585,0.10180725,-0.020610886,-0.10499247,0.009327385,0.01348287,0.014605157,-0.05267375,0.054943338,-0.085755125,-0.06725888,-0.06242464,-0.0057939724,0.013001429,0.105600365,0.02561495,0.034678597,-0.12647365,0.003288081,-0.030192103,0.03639554,-0.0035572893,-0.08010201,-0.05166895,-0.02953619,0.043877494,0.041857567,0.110236056,0.044443544,0.047027227,-0.0678665,-0.016451418,0.022652036,-0.047451943,-0.011224995,-0.04245743,-0.04087893,-0.09327438,-0.041033316,-0.013594014,-0.012680378,-0.029550621,0.021144997,-0.0984901,0.036371853,-0.054324977,-0.008285508,0.016140528,0.048154186,0.016966907,-0.031605437,-0.0160454,-0.017226305,0.048419878,0.0065238364,0.05072977,0.065327756,-0.060759295,-0.0085004,-0.0016638844,0.031055825,0.011403638,0.10280158,-0.004511506,0.04563402,-0.006475317,-0.023807166,0.05719449,-0.012362372,-0.017409664,-0.001413882,0.050723236,0.0026608475,0.07021669,-0.029429937,-0.0050777164,-0.019232908,-0.09789472,0.017148374,-0.0018927391,-0.08797264,0.07904372,0.045962438,-0.060483444,-0.06501463,-0.017197402,0.028323637,-0.06417234,0.1097266,0.061505646,0.006211018,0.07233593,-0.053453777,-2.0136349e-33,0.067312725,0.017813692,-0.011539272,-0.03796023,0.0027638653,0.012331439,-0.024855472,0.059141334,0.03822916,-0.04778123,-0.06759278,0.038521234,0.047960773,0.02968937,-0.004796329,0.025593178,0.003476315,-0.008601581,0.051595297,0.04665992,0.010721411,-0.055834506,-0.016164206,-0.032561988,0.04180789,-0.0044120275,-0.026799692,0.045696955,0.051669322,0.0010071469,-0.033892147,-0.09469595,-0.04342991,0.09374769,-0.016160026,0.10486357,-0.047593858,-0.053034436,-0.009289663,0.015410537,0.019404795,-0.03140533,0.023806732,-0.12233135,0.014936552,-0.003060486,-0.057871584,0.008276339,-0.0012005776,0.033847414,0.048460167,0.003039742,0.043708023,0.023169924,0.023836937,0.011857185,-0.05194408,0.021665618,-0.017478827,0.078632146,0.011700867,0.07050035,-0.004738783,0.0139554655,-0.012598768,0.04456669,-0.072440885,-0.054975364,-0.075861275,-0.023350008,-0.08540461,-0.058190092,0.09177985,-0.032828964,0.047231425,-0.051874787,-0.039185595,0.02596332,0.00081213424,0.039760232,0.01347042,-0.018838942,0.05984625,0.025068944,-0.048401963,0.06599963,0.015004063,-0.004107793,0.009123139,0.04464491,-0.026822118,-0.051381934,-0.07824858,0.065102994,0.03158544,-3.8068483e-34,0.021105114,-0.09712597,0.006737872,-0.07853281,-0.032457158,0.053342108,0.028197052,-0.0077016754,0.057832386,-0.0014532345,0.04042989,0.019212805,-0.06354599,-0.1371529,0.010231611,-0.0005234037,0.02708117,0.0715618,-0.04522941,-0.008593193,-0.037833914,0.077116586,0.042762667,-0.0037869613,0.05424485,-0.060743302,0.040485814,0.017276613,0.014973047,0.03505598,-0.056009494,0.044564504,-0.029492319,-0.020100785,-0.026092516,-0.010445702,-0.066028595,0.026809003,0.028703813,0.012043641,0.05057585,0.0764196,0.06411324,0.091953896,0.058755983,0.16015702,-0.06613326,-0.01965524,0.00908225,-0.028646173,-0.008184822,-0.028524274,0.008929976,0.07327179,0.040972937,0.09099553,-0.004031454,0.107408464,0.049578745,-0.024187282,-0.058442675,-0.031501558,0.021080423,-0.043257974,0.050008483,-0.055988666,-0.10071329,0.020428646,0.025316825,0.011216061,0.08726455,-0.107829265,-0.07180843,0.077915475,-0.062438775,-0.0063863187,-0.114661016,-0.13402002,0.0068422463,-0.062793106,0.061852656,0.041393504,0.007601931,-0.034948327,0.05242098,-0.021277742,0.023615375,0.15085946,-0.01555313,-0.0067046965,0.007798456,-0.016179228,-0.08310904,0.0051475707,0.07260208,-3.4928178e-08,0.014906941,-0.020516656,0.0073961713,-0.041420545,-0.028076688,0.03395308,0.084706895,0.07567282,0.028301336,-0.022650834,-0.04360015,0.08177831,-0.002959919,0.0010180278,-0.0081014745,0.022157867,-0.019458562,0.033316474,-0.034032993,-0.040514305,-0.034493286,-0.030546594,-0.029560784,0.0020421515,-0.07075688,-0.09370814,0.086007535,0.08515696,0.0014839304,-0.02736372,-0.084514774,0.011044504,6.172416e-05,-0.031150132,-0.009831263,0.028498743,-0.038377456,-0.050798208,-0.0044641206,0.024421751,-0.04478997,-0.13240132,-0.009446011,-0.018050058,0.0073357467,0.0092627,0.017193133,0.05496144,0.040905558,-0.009046934,0.049126454,-0.052246116,-0.013220714,-0.11534056,-0.039444998,0.013435409,-0.008400516,-0.08102686,0.027581986,-0.06051828,0.031035237,-0.0053681093,0.13886969,-0.027808242 +3.2.1.39,"Different from EC 3.2.1.6 endo-1,3(4)-beta-glucanase. Very limited action on mixed-link (1->3,1->4)-beta-D-glucans. Hydrolyses laminarin, paramylon and pachyman.",384,1.0,-0.007342827,-0.14931673,-0.020488929,-0.012296354,0.018190674,0.0014811482,-0.08204855,0.03099628,0.05568517,-0.003419731,0.059045818,0.05846268,-0.12749101,0.024882926,-0.027145693,-0.0074030417,0.015091085,0.008859037,-0.07962184,0.027973713,0.04500517,-0.0014644843,-0.03396687,0.040653992,0.009259073,-0.03361615,-0.0054895934,0.0077727726,0.017238399,-0.11068072,-0.01065052,-0.018365262,-0.005145076,-0.043554824,0.0042014085,0.024390653,-0.03133169,-0.08633567,-0.06043119,0.021210209,0.063252084,-0.040039916,1.5400827e-05,0.011102521,0.013049467,-0.032385007,-0.06286518,0.035923947,0.05757979,-0.0040667807,0.03503066,-0.12811431,-0.06864305,0.02129983,0.035543967,-0.059614968,-0.14271207,0.0032286127,0.084615156,0.09003796,0.0048318203,0.034750983,-0.03704006,0.016066412,0.011728422,-0.04980639,0.0155301355,-0.052754745,-0.037607387,0.035971224,-0.06470839,-0.065757714,-0.008654292,0.043734502,-0.014039438,0.054172486,-0.03160869,0.006250576,0.012209419,-0.07740587,0.04294924,0.0030839741,0.05108713,0.02604618,-0.015370974,0.023163997,-0.050761968,0.03284031,-0.0006063561,0.024458392,0.08328368,0.0019949472,0.030136859,-0.005853524,-0.035259534,0.036669992,0.06414905,0.032029435,0.06527824,-0.048454553,-0.023213796,0.0013930842,0.03910154,-0.069803745,0.06975001,0.043572057,0.0007868908,0.065278344,0.04474924,-0.0044932854,-0.047479622,-0.097242355,-0.03538569,-0.0589245,-0.07142465,-0.006017926,0.059368342,-0.06595578,0.012775809,-0.016825914,0.04838586,-0.048528243,0.08126566,0.014936858,-0.08246001,0.07111335,-0.030413387,-5.4375164e-34,0.05520515,-0.07583881,0.0054365764,-0.0036292663,0.009194815,0.0053414796,-0.077771604,-0.03290387,-0.021986367,0.028713431,-0.085205175,0.06517857,-0.021794436,0.1561952,0.077702895,0.058455694,-0.033060953,-0.0501965,0.024056597,-0.035957236,0.022068527,0.0804177,-0.048619535,-0.00068733905,0.09198769,-0.012343032,-0.009882832,0.016444383,0.05856199,-0.03518088,-0.0064646187,-0.05054192,0.0060440134,0.05650438,-0.03563151,0.12961607,-0.009343017,-0.07266814,-0.023211297,0.00087194535,0.0165654,0.019854862,-0.002183187,-0.05918522,0.056633953,-0.045999862,0.05196353,-0.022433117,-0.028542811,0.044044707,0.048168268,0.03788524,0.043732967,-0.03610518,0.020691507,0.0046096114,-0.034226973,0.101181485,0.017552212,0.070890054,-0.035392888,0.07190439,-0.007202216,-0.036802035,-0.023960516,0.0942163,-0.09102265,0.0036519673,-0.02947708,-0.053498063,-0.0811173,0.029241974,0.08316622,-0.021633198,0.06454554,-0.05488636,-0.0534474,0.026827006,0.004650205,-0.024698297,-0.030188723,0.046048988,0.01534565,0.13016845,-0.067430116,0.067279376,-0.008855429,0.0028414393,-0.0010335093,0.04838565,0.007528718,0.044827305,-0.0019965684,0.11014238,0.015405849,-1.760097e-33,0.056603987,-0.060764886,0.053111017,0.027085276,-0.007173511,0.100916795,0.02462882,-0.020089854,0.059510864,-0.029662164,0.092155494,0.0011303613,-0.018057061,-0.055172984,-0.002232091,-0.040270902,-0.09993603,0.006129565,-0.04520843,-0.0133722415,-0.029516788,0.04215679,0.035219636,0.02948407,0.06230047,-0.03490978,0.0584107,-0.014257769,0.037174735,0.018029293,-0.016376162,0.0021869182,0.0014992899,-0.03052545,-0.030214658,0.024892036,-0.035286427,0.02899932,0.047133386,-0.0065241954,0.015073143,-0.0014512561,0.056813236,0.027072752,0.050551664,0.13634737,-0.00372243,0.00365688,-0.0633742,-0.0027734607,-0.006078031,-0.039674062,-0.07863722,0.05442018,0.08868268,-0.029832521,0.09341061,-0.020408235,-0.074955195,-0.03602131,-0.06242569,-0.0040210774,0.07123242,-0.109136306,0.108816974,0.05281298,-0.058538202,-0.01633132,-0.015577409,0.04983298,0.070495695,-0.11787493,-0.008371477,-0.041337866,0.054831382,-0.058809854,-0.05095556,-0.08946199,0.005289812,-0.03922186,0.010481147,0.05869093,-0.0012416743,0.027133316,0.03376597,0.051766813,0.005399053,0.070694715,0.0039845216,0.062696375,-0.0025068147,0.0058070836,-0.040236536,0.08555383,0.002476271,-3.8845794e-08,0.07333816,0.045782942,4.4807326e-05,-0.10422012,0.00863309,0.049064044,0.0061888816,0.095219605,0.012389125,0.0903181,0.011644322,0.07064744,-0.029321734,0.0018481732,-0.02833288,-0.014300081,-0.035899263,-0.0178712,0.0018367096,-0.045958366,-0.13237922,-0.009640285,-0.046191014,-0.02217273,-0.0010561496,-0.11652481,0.013173038,0.051766086,-0.029989652,-0.03822536,0.014557472,0.051837523,-0.077128515,-0.033220693,-0.041142464,0.021752136,-0.06241448,0.03891838,-0.006211598,0.08653488,0.028169433,-0.06559048,-0.013800617,-0.00034072294,-0.014697421,-0.04261212,0.03990538,-0.022696774,-0.041557804,-0.023607656,0.037365187,-0.060090225,-0.046439886,-0.09812087,-0.055883385,-0.017960923,-0.027902028,-0.03954985,0.045550365,-0.056827083,-0.018633608,-0.08361639,0.06116309,0.09735379 +3.2.1.40,"The enzyme, found in animal tissues, plants, yeasts, fungi and bacteria, utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnose. Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnose.",384,0.99999994,-0.019075425,-0.06557404,-0.05378539,0.041137062,0.11581219,0.06101726,-0.06574782,0.03780454,0.02204216,0.018562581,0.01946298,0.04503534,-0.08551476,0.07536327,-0.08547248,0.03293033,-0.054267913,0.018811457,-0.009708344,-0.030756323,0.08086242,0.024550186,-0.038992148,0.025456818,0.06489738,-0.05951715,0.039689098,-0.049784902,0.019506821,-0.07556687,0.039900135,-0.011129918,0.077674866,-0.05398124,-0.07768269,0.13118213,-0.017932761,-0.07743421,0.08409474,0.05340052,0.02025935,-0.049464963,0.03565742,-0.052694008,-0.0068290727,-0.03535623,-0.09467768,0.04300034,0.097044624,0.02684958,-0.0066887606,-0.05333558,-0.036418255,0.04984116,0.0014269119,-0.0035257856,-0.072324105,-0.0318134,-0.03285657,0.06161735,0.06358018,0.05079088,-0.05610296,0.06912958,-0.07162568,-0.043677267,0.014677095,-0.00072512164,-0.01694996,-0.0140546635,-0.036658842,-0.08508379,-0.013036682,-0.04058986,0.020228045,0.011909461,-0.03174679,-0.033813935,-0.027728764,0.014142347,0.11341308,0.0057246233,0.02556548,0.0576408,0.021565352,0.030433828,0.016149946,0.03467766,0.031166464,0.041658282,0.012738505,-0.04133528,-0.03593282,-0.048642144,-0.0549805,-0.02970651,0.019956479,-0.013271407,0.03312668,-0.029141447,-0.019417653,0.04585171,-0.0026092264,-0.085131265,-0.084764734,0.061510004,-0.046558425,0.053522345,0.071657844,-0.01980685,0.010965474,0.07179626,0.007984047,-0.027968852,-0.033693362,0.0046830424,0.020653253,-0.07866079,-0.11880841,-0.01220715,0.02119153,-0.010235981,0.02765244,0.0048764828,-0.031023668,0.044887215,-0.037806213,2.6695974e-33,0.070584975,0.013825887,-0.0705642,-0.047383748,-0.010588035,0.027211903,-0.093597285,0.047647327,-0.00537314,-0.032678638,-0.017939087,0.007957844,-0.014911126,0.05366614,-9.598621e-05,0.027790014,0.07673875,-0.00712016,0.06477195,0.007015697,-0.019028839,0.020694377,-0.0974,-0.014061692,0.034340657,0.056251936,-0.0014793992,0.011689265,0.02151683,-0.040901292,0.035889193,-0.045690022,-0.0628827,0.083623156,0.014546187,0.05125954,-0.06435663,-0.06569395,0.01937788,0.046492748,0.074322,0.022389585,-0.0011350705,-0.020319883,0.013539138,-0.05127411,-0.052651122,0.008524476,0.059265606,0.08111493,0.06479261,0.024710326,0.057538845,-0.028270185,-0.0071915165,0.018884761,-0.040235132,0.02265219,0.026380943,0.07455201,-0.035475638,0.030243393,-0.018202843,-0.0045726197,-0.00772403,-0.009578698,-0.047990154,-0.09240552,-0.03455568,0.029152934,-0.10150658,-0.015442788,0.042216502,-0.014215579,0.0061416873,-0.052558444,-0.028411575,0.021144923,0.042789362,-0.004627295,-0.026655542,0.004519554,-0.009182252,0.016118817,-0.02511847,-0.011595141,0.03171304,-0.03559156,0.010770914,-0.030080393,0.0043655443,-0.09652127,-0.09670305,0.028324816,0.03808461,-4.8579626e-33,0.10868657,-0.121266834,0.03259122,-0.053920683,-0.06032179,0.07280848,0.06089551,-0.023314591,-0.020511309,-0.050780907,0.004532554,0.031524777,0.00046859,-0.004446721,0.051969845,-0.0587014,0.036885977,0.05516777,-0.038698338,-0.045633752,-0.05663761,0.09107737,0.09681134,0.02078471,0.06592959,-0.019735169,0.022842161,0.04488736,0.032648433,0.049923826,-0.04006673,0.013151532,0.0033262938,-0.09197982,-0.027550876,0.13139445,-0.06612041,0.038568135,-0.0017911773,0.016243989,0.054843884,0.053116463,-0.031547714,0.06584481,0.03207571,0.07807475,-0.120342396,-0.014299667,0.019114709,-0.0382366,0.03060414,0.015942259,0.023170104,0.01709038,0.03782393,0.020523788,-0.05523656,0.0057652476,0.04112666,-0.04882155,-0.075818025,-0.033472657,-0.04975342,-0.019960154,-0.025424013,0.05873401,-0.0051157605,0.020948643,0.031117609,-0.013045339,0.064443514,0.03104958,0.07569092,0.069774985,-0.07361812,-0.027825868,-0.1039627,-0.13139142,-0.040303253,0.012967058,0.042953733,0.0036416582,-0.018055262,-0.027082536,-0.020974282,-0.12586482,0.018693645,0.08246339,0.014189089,-0.011747145,0.018311603,0.028593443,-0.11441558,0.019333316,0.12316848,-4.0929862e-08,0.024548657,-0.083743095,0.10029395,-0.067591265,0.014574307,0.036996897,0.0814055,0.013763351,-0.025392214,-0.006769474,-0.05471704,0.11275345,-0.03454643,0.0115497615,0.050422195,0.047259837,-0.033767838,0.057540238,-0.031159325,0.060949717,-0.06294291,-0.001828351,-0.063360125,0.02643174,0.0017867796,-0.08006282,0.067550085,0.057956316,-0.027097818,0.0038553723,0.025965258,0.054073337,0.011476223,0.0009421443,-0.07180214,0.009495595,-0.03221793,-3.987409e-05,-0.012032503,-0.03882771,-0.015315902,-0.034338932,-0.055729236,-0.003880269,-0.08894095,-0.018600425,-0.0047187647,0.047367036,0.027763426,-0.0045991368,0.03810305,-0.064262085,-0.049079593,-0.09126088,-0.088406354,-0.040550224,0.0023882096,-0.04385489,-0.005262311,-0.07006719,-0.052746467,0.020844778,0.21183848,-0.037531644 +3.2.1.41,"Different from EC 3.2.1.142 (limit dextrinase) in its action on glycogen, and its rate of hydrolysis of limit dextrins. Its action on amylopectin is complete. Maltose is the smallest sugar that it can release from an alpha-(1->6)-linkage.",384,1.0,-0.011051977,-0.1008632,-0.013341987,-0.00029231916,-0.0035650004,0.01490974,0.029067855,0.052305225,0.031612724,-0.056502197,0.04347598,0.039590865,-0.119279034,0.0045368196,-0.071217306,-0.03906305,0.003316281,-0.034940023,-0.06945779,0.03260265,0.15044366,-0.0029146983,0.007816572,0.06300298,0.0424823,0.0009785355,-0.023411013,-0.006040511,0.023140991,-0.093993455,-0.015172218,-0.034720797,0.04929367,0.018356511,-0.0030474057,0.071689054,-0.026644878,-0.09391623,0.022375928,0.0020588392,0.03031411,0.0008342456,0.000977822,0.06294087,-0.06845896,-0.07239396,-0.07673443,-0.0801546,-0.035074074,0.030328328,-0.006603564,-0.076797545,-0.05723492,0.016256811,0.0834596,-0.01642102,-0.11039762,-0.011479193,-0.0077476003,0.034494944,-0.026757447,0.11242467,-0.0438213,0.00402982,-0.006898317,-0.06772304,0.07000182,-0.11279549,-0.054441653,-0.010634987,-0.04438237,-0.02897709,0.0061352802,0.05713348,0.04055105,-0.032139298,0.00014815401,-0.03973089,0.0051532146,-0.008993023,-0.019385923,-0.02953732,0.039408334,0.0657839,-0.12879422,-0.102017626,0.054249097,-0.001707827,0.041924547,0.056718245,0.03841716,0.0047065145,0.030558629,-0.028630875,0.08796483,0.027957194,-0.01774813,-0.094452,0.015704036,-0.00427758,-0.026132066,0.10336401,0.034357756,-0.009325985,0.0019394356,0.059574023,0.016618831,0.031900205,0.011823837,0.060901858,0.024993587,-0.013107498,0.0405536,0.003843383,-0.08544853,0.050454322,-0.03032268,-0.06724696,0.061189227,0.025384365,0.011788085,0.01892544,0.08703309,0.02693534,-0.032427464,0.11505872,-0.08320842,-2.4325592e-33,0.08605153,-0.07425292,0.005542999,-0.08316861,-0.013976377,0.055130553,-0.0769114,0.040888086,-0.006148999,0.011751627,-0.13372302,-0.040672183,0.007336164,0.0658262,0.033058986,-0.028581733,0.03693763,-0.01662377,0.04605082,0.061966542,-0.030021986,0.017961819,-0.010861049,-0.017659098,-0.005696951,0.01873383,-0.05145386,0.053814,0.037152033,-0.014720278,0.02646748,-0.011803754,-0.03293896,0.07422211,0.05067616,0.061704572,-0.017543629,-0.014254572,0.07029493,0.02282093,0.022802874,0.056163896,0.034955874,-0.059173692,0.059705794,0.03065543,-0.0033812663,-0.013787018,-0.043622565,0.06781575,0.0428766,-0.01684288,-0.065905936,0.043556392,0.016134689,0.053909037,-0.04399443,0.045435816,-0.01537495,0.110378705,-0.015228855,0.07887626,0.080974266,-0.059952334,0.051225696,0.06554855,-0.06961866,-0.056029473,-0.065781295,-0.025289835,-0.07251192,-0.048143048,0.095573016,-0.035360396,0.016515018,-0.05668684,0.0190185,0.0053495457,0.015575001,-0.08435494,-0.057247862,-0.047250595,0.056673743,0.008547379,-0.12015314,0.03204421,-0.016222477,0.021923799,-0.05118311,0.04189802,-0.033870824,-0.015979167,-0.027779872,-0.033557504,-0.026234796,-4.6386224e-34,0.09281196,-0.086022556,0.023229176,-0.02780732,-0.023278534,0.05402088,0.029570723,-0.0064191213,-0.010570888,-0.0057359403,0.04966463,0.089051455,0.038744822,-0.12865725,-0.011625527,0.010154942,-0.07655772,0.030359287,-0.039912917,0.044115547,-0.021425204,0.10204593,0.0075492607,0.05177519,0.09222089,-0.060934704,0.028693432,0.056607034,-0.010657822,-0.03700792,0.019246953,-0.03074416,-0.029320618,-0.10809791,-0.048713315,-0.014949089,-0.032289032,-0.04630765,-0.011427882,0.011790773,0.026020307,0.0362163,0.036288474,0.047783587,0.06984028,0.07877489,-0.041431013,-0.04965264,0.0317555,0.018231062,-0.03959524,-0.05868511,0.019553475,0.086784706,0.015510775,0.01668263,0.016465938,0.001284129,-0.04544464,-0.0030314093,-0.013583226,-0.0029813491,0.028801408,-0.047724776,0.045940775,0.00025226164,-0.056896344,0.023586802,0.06178103,0.049715325,0.041409295,-0.059025716,0.03205751,0.005253533,-0.0070142755,-0.056843687,-0.070336364,-0.06658164,0.010656426,-0.08297922,0.06393995,0.12584624,-0.02887424,-0.041313365,0.013549055,-0.07713874,0.062725455,0.0739218,-0.015280773,0.05264431,-0.04116462,-0.04460791,-0.023950655,0.01653645,0.0012121211,-3.6576395e-08,0.063780285,-0.024769919,-0.018120747,0.009233528,0.045802154,0.06195561,-0.010377464,0.046264295,-0.027245937,0.031148741,0.02416877,0.122140005,-0.04845703,0.035021055,0.004478382,-0.033711895,-0.04305808,0.031194359,-0.040265802,-0.0018012361,-0.14530887,0.018203076,-0.11739238,-0.005668344,0.0061505237,-0.075182825,0.062981606,0.09718475,-0.05212082,-0.0012766592,0.059371304,0.061866663,0.029999249,-0.061757438,-0.030436875,0.0051274598,-0.016844368,-0.0029228171,0.020347336,0.007029095,-0.007551534,-0.092739865,0.012625832,-0.01721306,-0.042559016,0.00034240147,0.006595916,-0.019562144,0.02117768,0.077874504,0.059053317,0.025840474,-0.07260848,-0.012708674,0.0005055835,-0.011269809,-0.07892554,-0.053868756,-0.04367389,-0.025035126,0.028891237,-0.04403453,0.12322393,0.014148045 +3.2.1.45,Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase).,384,1.0,-0.031972945,-0.06926969,-0.06278658,0.019102974,0.015654892,-0.02809112,-0.012095264,0.058612075,0.05877445,-0.022920435,0.082615845,0.040812153,-0.059125613,0.08114235,-0.038315896,0.030901438,-0.009352056,0.022245036,-0.021250054,-0.051865295,0.081175715,0.012840382,0.0067921937,-0.024072075,0.03445312,-0.0169751,0.013958558,-0.021949284,0.022279179,-0.031928323,-0.068462774,0.002106623,0.0011915752,-0.0012055091,0.05297452,0.026927156,-0.10930679,-0.03841174,0.09305361,0.026632514,0.026500648,-0.08674855,0.03400559,-0.049231507,-0.017326402,-0.022251412,-0.014348799,0.07858436,0.021261485,0.09221583,0.035897966,-0.04852626,-0.027418396,0.024038251,-0.0005660718,0.0011984851,-0.13475671,0.023529306,0.020139553,0.027438842,-0.0032504278,0.033579264,-0.02930307,0.044874277,-0.05197622,-0.027426776,0.10910077,-0.07353817,-0.02248389,-0.0022703388,0.02592889,-0.03436522,-0.008388081,0.023276798,0.055022866,0.07309024,-0.019624345,-0.042928506,0.045147195,-0.05418836,0.0894488,0.03386842,0.120892495,0.061348684,0.019407628,-0.004696735,-0.018383477,-0.0010480336,-0.04144003,-0.024411945,0.037297416,-0.08572952,-0.039736502,0.031701893,-0.023917016,0.017691396,-0.025040278,-0.011804657,-0.04204786,-0.008852109,-0.09229523,0.0053823236,0.022267234,-0.010285123,-0.03446209,0.09669082,-0.013411394,0.029528297,0.017505603,-0.01092711,-0.0033114103,0.056171406,0.031928763,-0.042016078,-0.051794298,0.0521461,0.0493344,0.011871117,-0.055737756,-0.012148832,0.025949439,-0.04872119,-0.015194488,0.01571797,-0.07143169,0.06714578,0.06742442,1.8921167e-33,0.022082143,-0.012500706,0.02919318,-0.043675594,0.040887926,-0.035552677,-0.02880262,-0.07501687,-0.050200492,0.019967793,-0.05917715,-0.08248418,0.03691694,0.11584125,-0.0421789,0.065170884,0.013991253,-0.04249962,0.06855114,-0.039573427,0.05485881,0.086997144,-0.036091123,-0.071096495,0.007059871,0.050505273,-0.076023504,0.03326279,0.025579639,-0.021023149,0.011609457,-0.043303918,-0.07128859,0.054991737,-0.012474731,0.048478488,-0.063866355,-0.08640499,0.038421214,-0.0075202608,0.011434548,0.020014115,-0.062234502,-0.06382915,0.020659346,-0.011862737,-0.073299415,0.036379304,0.050562214,0.07487202,0.07759772,-0.008432587,0.07040942,0.02138892,-0.02577264,-0.007057847,0.031542942,-0.05617739,0.03850715,0.06520992,0.03444191,0.055475276,0.012801467,-0.029473826,0.027272796,0.04749772,-0.1435981,-0.043537214,-0.08876573,0.020479158,-0.021793356,-0.022771489,0.059428975,-0.013312104,-0.02246621,-0.07292149,0.025785144,0.013552151,-0.021958314,0.021512467,0.013358511,-0.09211494,0.07865122,-0.008305588,-0.07633271,0.06597111,-0.040769275,-0.15429088,-0.004388741,0.014875089,0.033863034,0.0024847754,-0.083431415,0.03925004,-0.01900555,-3.9481476e-33,0.06064894,-0.05160172,0.03217218,-0.0060237027,-0.04241865,0.04551542,-0.02833532,0.00020519641,0.001526601,0.0017005586,0.048348334,-0.022334287,-0.07227044,-0.029528731,-0.010347799,0.02945404,-0.008699724,0.050921787,-0.03876338,0.04466951,-0.035433937,0.10639474,0.022836765,0.08435224,0.08814946,-0.04763182,0.04251672,-0.025654182,-0.033947468,0.045139734,-0.035833985,-0.00982646,-0.062135506,-0.07666814,0.03435785,-0.0077898856,0.0034172535,-0.017155994,-0.04908924,-0.07162122,0.0036492846,0.02747082,0.061026916,0.12274322,0.11178405,0.099487275,-0.03114898,-0.052116815,-0.086561196,-0.068978004,-0.034496933,0.046080302,0.026278088,0.07837441,0.080070965,0.09661647,0.060648996,-0.07774991,0.012169159,-0.04572007,-0.057341345,-0.024214413,-0.056194767,-0.068496525,0.18781553,0.06780922,-0.07912997,0.0662963,0.08020459,0.03399116,0.042066075,-0.055227067,-0.049529906,0.017566808,-0.0728272,-0.027182566,-0.040660888,-0.056846168,-0.00729605,-0.0050750435,0.038788665,-0.01640353,0.027578995,-0.021126453,0.011297901,-0.06379906,0.0033879313,0.12876421,-0.029828617,0.079511955,-0.023363428,0.017417295,-0.020497361,0.01932449,0.017831296,-3.4128416e-08,0.034267776,-0.019396946,0.027348677,-0.09735154,-0.031824473,-0.015316924,0.07943146,0.05211888,-0.020134097,-0.0079797,-0.09319324,0.10060134,0.06665307,-0.012385159,0.03395924,0.011590422,-0.06149791,0.022004291,-0.027979754,-0.02692089,-0.09844779,-0.0415828,-0.034155414,0.01999107,-0.020155778,-0.08331048,0.08312834,0.09472148,-0.022724522,0.010430379,-0.04219754,-0.021434685,-0.05189831,-0.030505909,-0.0016310684,0.034638546,-0.018095203,-0.028652195,-0.012676042,-0.0028453507,-0.03825598,0.013139355,0.010340596,0.019865675,0.011448931,-0.011927595,0.03212577,-0.014926228,0.018943653,0.019421691,0.013864743,-0.032643586,-0.040803492,-0.020809315,-0.11334296,-0.04893796,-0.04721023,0.006496306,0.069186494,-0.08730265,-0.014628564,-0.00554111,0.11293862,0.010048959 +3.2.1.46,cf. EC 3.2.1.62 glycosylceramidase.,384,1.0,0.0077737435,-0.021104973,-0.10334459,0.006942746,-0.036832917,-0.042854317,-0.016986867,0.072814524,0.006868679,-0.04162102,0.10510749,-0.05738947,-0.052038968,0.008121733,-0.104105845,-0.08490507,0.01768872,-0.07591094,-0.05125036,0.018775992,0.05667818,0.09162181,-0.004406528,0.027122755,-0.023821825,-0.00013073848,-0.02495928,-0.033806555,-0.015886191,-0.041193,-0.018752929,-0.00041231344,0.0908349,-0.065868005,0.10962812,-0.047414698,-0.033517543,-0.07248053,0.042098973,0.053526584,-0.043918665,-0.039648276,0.069830775,0.017782439,-0.052494276,-0.034017034,-0.030007422,0.093513735,0.059721302,0.022311483,0.00020303224,-0.08266292,-0.08227125,-0.0009733921,0.035267193,-0.04775458,-0.075816974,-0.0054392125,0.009848232,0.038797792,0.08299416,0.07676122,-0.030218054,0.031385887,-0.049792603,-0.055626195,0.14707117,-0.10820161,-0.004352204,0.03549689,-0.023254195,-0.039725572,-0.010293643,0.023720145,0.010542839,0.073523045,0.005597422,-0.051043507,0.08067912,-0.04674557,0.060241677,-0.025688188,0.10068738,0.062013064,-0.008206138,-0.031604387,0.020181151,0.0321746,-0.0047047823,-0.046118945,0.031204512,-0.07073054,0.02532893,0.009800684,-0.07591454,0.049930267,0.028208714,-0.00058083114,0.0020465925,0.032669593,-0.026629196,0.015978524,0.03855876,0.012661445,-0.11560856,0.0800151,-0.050799534,0.077235244,0.056104112,-0.007829319,-0.039749302,0.059567384,-0.015090433,-0.06176911,-0.061643973,-0.0021577727,0.05532327,-0.006402516,0.028234363,0.017409388,0.03563012,-0.03305507,0.045819327,-0.030819986,-0.014282246,0.0024244867,0.026494846,-1.4500992e-33,0.007350305,0.010916292,0.07090203,-0.031783007,-0.0011023362,-0.0652844,-0.06035232,-0.08348647,-0.07292365,0.048519783,-0.043379962,-0.03294226,0.011412816,0.09797833,-0.00043637346,0.054695196,0.019714698,-0.0339068,0.021006119,-0.0025487556,0.0142202675,0.06832225,0.022692978,-0.06490205,0.08277478,0.047905184,-0.014001426,0.004850807,0.041467343,0.0236234,0.038098134,-0.106799684,-0.09974967,0.052452426,-0.03505943,-0.03334144,-0.0045101056,-0.095965736,0.044239014,-0.019389998,0.03152783,0.05835827,0.027021997,-0.047194473,0.051735308,0.052493956,-0.03777307,0.06077343,0.05210529,0.06625519,0.034037948,-0.01309601,0.044502284,0.05556646,-0.050658163,0.02723801,-0.0045879115,0.043322887,0.06701513,0.028924461,0.047207974,0.11296242,0.0063743666,-0.016254267,-0.0010236535,-0.011144208,-0.15462908,-0.015841728,-0.025407733,-0.014204812,-0.06341269,-0.047935806,0.09247443,0.0143656805,0.026580658,-0.095646404,0.025614182,0.046365142,-0.08221781,0.0010294592,-0.099863134,-0.012868979,0.01378248,0.011552427,-0.056076344,0.08517934,-0.053651206,-0.048330262,0.009721703,0.08164197,-0.029138196,0.0065617873,-0.061349563,0.03835319,-0.059452172,-1.4721443e-33,0.08553353,-0.02397778,0.010421112,-0.034478273,0.002795789,0.02104157,-0.054229446,0.089539155,-0.01341817,-0.051799677,0.07697263,0.046315327,0.008178599,-0.07198075,0.011544327,0.053028896,0.050942153,0.0033534046,-0.05392935,-0.010540487,-0.0015072516,-0.0018365822,0.0059688156,0.03286208,0.053427346,-0.05776034,0.07030842,0.007871144,-0.07873528,0.048368704,0.009691166,0.0006645285,-0.025777712,-0.0380198,-0.03267043,-0.029951835,-0.018954212,-0.04536982,-0.022197403,0.018893253,-0.00901323,0.10307031,0.027731678,0.10352478,0.10629579,0.10662771,-0.014039983,-0.05230609,0.033364926,-0.054161325,-0.0024586867,-0.0028234832,-0.0004453979,0.033187743,0.07464356,0.037509155,0.012319829,-0.0070194784,-0.007703117,-0.0037195478,0.0047420855,0.022827953,-0.050695274,-0.041779958,0.16809249,0.07996638,-0.14550537,-0.0035613638,0.071383804,0.04956078,0.027693283,-0.07638824,-0.048260596,0.040703792,0.00568168,0.0044069556,-0.0904937,-0.015497965,0.0025620172,0.013431468,0.052059736,-0.008391833,0.015103139,0.043184094,0.057994604,-0.13242786,0.03532872,0.07745076,-0.005903699,0.023304665,-0.03062948,0.029241715,-0.052601732,0.023964977,0.06112466,-2.4581421e-08,0.085582845,-0.06787366,-0.018685002,-0.06963731,-0.009498515,0.0560727,0.01440535,-0.00232946,0.032050632,0.008035089,-0.051877975,0.051478583,-0.01394652,0.009738054,-0.06073461,-0.006978533,-0.08973073,0.04780588,-0.03427937,-0.007459673,-0.061975155,-0.023723882,-0.011656722,-0.025696952,-0.010884663,-0.051869683,0.088398024,0.014069581,-0.07062784,0.012350552,-0.065128975,0.028700804,-0.05547176,-0.03344906,-0.056251526,-0.013861437,-0.04448533,-0.0012766037,-0.00902805,-0.010405388,-0.002154554,-0.004615892,-0.040852945,-0.024802975,0.040355988,-0.02580613,-0.014006717,0.07742576,-0.037799634,-0.06785583,-0.011030494,0.007170588,-0.043653037,-0.009337541,-0.07402973,-0.04332787,-0.04563857,0.01679403,-0.052876297,-0.07942368,0.0038302492,-0.032086596,0.09291674,0.0030540754 +3.2.1.48,"This enzyme is isolated from intestinal mucosa as a single polypeptide chain that also displays activity towards isomaltose (EC 3.2.1.10 oligo-1,6-glucosidase).",384,1.0,0.0065478375,-0.09071948,-0.09615046,0.026470555,0.04244399,-0.010763905,-0.017449388,0.029081928,0.0708253,-0.06879131,0.04760524,-0.007955628,-0.08724533,-0.014798855,-0.026605275,0.038290493,0.0061374363,-0.01643241,-0.030374313,-0.08807775,0.09285657,0.013820623,0.02123702,0.008680738,0.00010592883,-0.08284151,0.10714077,-0.017428955,-0.025092015,-0.09686501,0.015096125,-0.1496411,0.068941645,0.03343833,0.06343974,0.03753476,-0.0008369093,-0.036798265,-0.0038255828,0.0064556543,0.011970712,-0.01711663,-0.0198238,-0.09297584,-0.06424538,-0.11459463,-0.051312987,0.009263817,0.052426465,0.031953454,0.0025233726,-0.09972876,-0.012696422,0.01495794,0.05156142,-0.0077342973,-0.0804471,-0.031856824,0.002988765,0.029833803,0.06392017,0.036409624,0.023327356,0.024738442,-0.0042300853,-0.04100304,0.11427233,-0.02618435,-0.018316392,-0.08214842,-0.0812484,-0.046714794,-0.03800362,-0.012249812,0.018585064,-0.020060042,-0.042360693,-0.0115386695,0.028532963,0.051241484,0.025830114,-0.008222002,0.012184053,0.07561527,-0.0014803457,-0.010538253,0.0095748175,0.10534098,0.0043068375,-0.04418675,-0.0043348526,-0.043133955,0.017391764,-0.039127145,0.0711183,-0.023154113,-0.05208564,0.0027292466,0.039147593,-0.00020758488,-0.047190312,0.0495145,0.021422999,-0.060904935,-0.07099189,0.071217604,0.03493181,0.05164551,0.039425068,-0.011288883,-0.0368461,0.020229302,0.039721187,0.036606908,-0.040656164,0.04945556,0.057006586,-0.04343604,0.022751477,0.078574315,0.010160202,0.0076752296,0.09394789,0.07938921,0.0067603467,0.061949283,0.01688977,7.896983e-34,0.013393003,-0.0027931014,0.047301423,-0.055346362,0.013071204,0.036661748,0.019349923,-0.031159058,-0.074048415,0.038410503,-0.08854639,-0.042224776,0.048521522,0.10216632,0.031686183,0.046571024,0.021603664,0.0015459622,0.07485548,-0.011155274,-0.012127486,0.05819613,-0.020335382,0.0012998416,0.004369264,0.06519446,-0.02877771,0.06325316,0.035509817,-0.00927013,-0.0009243139,-0.05475501,-0.08006349,0.067014545,0.034852386,0.043713756,-0.029706744,-0.009098602,3.8589194e-05,0.034706585,0.00026440085,-0.02371972,0.04620117,-0.09806237,0.059992928,-0.03790906,-0.10212906,0.044075806,0.072903715,0.09166134,0.022337072,-0.028335799,0.040860698,-0.06546947,-0.036904905,-0.023404066,-0.019775162,0.03609516,0.047906134,0.032931432,-0.061441105,0.05794947,-0.028479658,-0.00055843336,-0.013710135,0.083275534,-0.12448062,0.00067651464,-0.04816956,0.07798758,-0.10532151,-0.003353667,-0.027417488,0.01170464,0.044530433,-0.08811644,-0.08063878,-0.0064200563,0.03190894,0.010118273,-0.042493243,-0.031931482,0.040518627,0.007992837,-0.091520086,0.044640683,-0.057996176,0.028682828,0.028492177,0.10505828,0.00731238,-0.00092747033,-0.12240121,0.09672672,0.04885344,-3.2075887e-33,0.047378954,-0.0051486553,0.051062454,-0.107961625,-0.033951804,0.07738125,0.013172079,0.058726728,0.0043101935,-0.008643926,0.06772992,0.046500985,0.030341944,-0.05665963,0.035274662,0.060470924,-0.04093227,0.06730394,-0.007834766,0.03542431,-0.07136973,0.028022442,0.003997541,-0.042964593,0.058744904,0.030952325,0.039714698,0.058407206,0.005559331,0.018119857,-0.055181693,0.01686905,0.001757311,-0.0702813,-0.031811662,0.0002385383,-0.083341755,-0.05422928,0.0137354955,-0.0056442805,-0.10626461,0.07799291,0.01233677,0.0521312,0.013951541,0.11663407,-0.020392274,-0.023448471,-0.11637623,-0.023864321,-0.046722494,0.047490235,0.023777872,-0.04130248,0.054010894,0.057030544,-0.017318854,-0.018719794,-0.031967368,-0.05802743,-0.006607387,0.010949741,0.011631844,0.006478985,0.09913051,0.045268375,-0.043866966,0.008223051,-0.10534476,0.02188492,0.07257541,-0.042254146,-0.00953028,-0.012447616,0.02138605,-0.05652595,-0.13852897,-0.018343046,-0.009298247,0.00886251,0.04200388,-0.034239076,-0.011163209,-0.10337815,0.029089581,-0.07483711,-0.0043796427,0.060174298,0.054108858,0.06632608,-0.024197266,0.027360354,-0.08637596,-0.011845013,0.08344305,-3.3074407e-08,0.063586615,-0.08705895,-0.017838009,-0.05242061,-0.037103847,0.012387411,-0.0122736525,0.0008637286,-0.04638946,0.054970402,-0.01024993,0.088427156,-0.0315548,0.024117814,-0.033476,0.005797859,-0.020651596,-0.008703448,0.026703727,0.020449908,-0.093934156,-0.009453801,-0.056030866,-0.0019235191,0.04051702,-0.045599326,0.020681415,0.079742625,0.007925852,0.005464196,0.0007222882,0.05446167,-0.03482762,-0.012129362,-0.101619355,0.07649781,-0.024552856,0.029858856,-0.031575486,0.0040033334,0.042022724,-0.05190783,-0.024787279,-0.055916015,-0.016613744,0.037435684,0.0001295912,-0.024778673,-0.043887295,0.013907487,-0.040480293,-0.07484545,-0.012677913,0.013164284,-0.02944759,-0.054572947,-0.013771963,-0.099247664,-0.008548864,-0.045949254,0.028442703,-0.019268585,0.18933658,-0.026110902 +3.2.1.49,The human lysosomal enzyme is involved in the degradation of blood type A epitope. 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+3.2.1.50,Hydrolyses UDP-N-acetylglucosamine.,384,1.0,-0.047514863,-0.058729548,-0.037297547,-0.01766903,0.0020282434,-0.013386914,0.05131997,0.08444295,-0.07306039,-0.010825566,-0.026669368,0.024425166,-0.048428822,0.03514836,-0.1504118,0.024737261,0.052530937,-0.10317959,0.037656095,-0.0055672554,0.029769288,0.007200191,-0.04208964,0.017901119,0.041657943,0.09030861,0.081634305,-0.0045511657,-0.0202577,-0.10178691,0.03752695,-0.051856767,-0.0007490881,-0.020490738,0.09594572,0.09462745,-0.031013703,0.03129838,0.039835256,0.02670028,0.054779116,-0.0340398,0.0064902576,-0.010594249,-0.033793233,-0.033432532,-0.04537215,0.03650112,0.044224266,0.05560462,0.09898651,-0.059751675,-0.020428771,0.078481846,-0.01119276,-0.04105561,-0.088325776,0.042129017,-0.023773635,0.09234525,-0.024660686,0.09624285,0.0072105145,-0.04171792,0.036879096,-0.027383922,0.07078678,-0.05050896,-0.01374906,0.09931879,-0.0038817455,0.0031494393,-0.0037222353,0.0060276985,-0.026233574,-0.0414604,-0.032654643,-0.08035218,0.08923361,0.0037412024,-0.015510509,0.035897497,-0.0054472345,0.08530429,0.022219105,-0.004540804,0.008270562,-0.016647482,0.040274356,0.015521865,-0.099965274,-0.027875222,0.016603937,0.004366375,-0.0985031,-0.052898467,0.053744316,0.036956716,-0.018713944,0.015595126,-0.021981996,0.038577717,-0.04178408,-0.12996022,-0.026671782,0.030636385,-0.00014574433,-0.0019408897,0.077293545,0.030832658,-0.096946344,0.054219004,-0.007777635,0.029847465,-0.03836187,0.0330542,-0.035189744,-0.035961706,-0.049261697,-0.050227683,0.0017952636,-0.04443838,0.055861488,0.012908683,-0.03277805,0.021587804,0.057044864,-2.749293e-35,-0.0034365293,-0.036077276,0.029602768,0.0039298176,-0.011643282,0.022608513,-0.029884115,-0.011415018,0.0034120092,-0.013386506,-0.030021029,0.017419232,0.04357013,0.14434563,-0.008440988,0.0064971563,0.04139074,-0.0077722026,0.020600736,-0.044136714,-0.050831296,0.09148924,-0.08409924,0.021009047,-0.065707326,0.020744195,-0.0893372,0.060476247,0.1101858,0.004675317,0.034024037,-0.048779253,-0.09614402,0.04213681,-0.03874189,0.01863723,-0.024558678,-0.070917234,0.04687776,0.0102399085,0.039938487,0.013962432,-0.00021735705,-0.0047146133,-0.03226788,0.0713721,-0.084393546,-0.033773735,-0.03526155,-0.0054476294,0.012747486,-0.058423664,0.049643163,-0.017337078,-0.03142634,0.008526364,-0.060266566,-0.048635993,0.020756355,0.07175331,0.0342663,0.08473414,-0.009309611,-0.056139402,-0.077329524,-0.03836399,0.008639243,-0.02151139,0.06467175,-0.06728665,-0.07677627,0.027087498,0.1007309,0.044347342,-0.005649526,-0.07048318,0.056307476,0.060160346,0.014185879,0.041855194,-0.034029018,-0.061252058,0.04293082,0.03533117,-0.02166272,0.044743706,0.029064272,-0.058003116,-0.016882895,0.082723565,-0.025906602,-0.1029449,-0.045819417,0.005659853,-0.009961124,-2.5892542e-33,0.10641378,-0.06823019,0.010845801,0.0035162123,-0.022290189,0.03554135,0.07056588,0.00026690154,0.006331517,-0.042421013,0.045240067,-0.045238797,-0.01675301,0.033002097,0.071194865,-0.009539236,-0.007835546,0.037301455,0.0066401456,-0.004136067,-0.047183905,0.06101012,-0.05407301,0.051573507,0.045536555,-0.019469742,-0.044635095,-0.0059989374,0.029977513,0.08200128,-0.00015876359,0.048290886,-0.07855988,-0.076033525,-0.0272959,0.008451657,0.042607836,-0.06453256,-0.09213804,-0.07767349,0.004127378,0.048120745,-0.04985962,0.07288767,0.07229438,0.12814221,-0.08780321,-0.049297623,-0.057465672,0.033577304,0.059629574,0.01269403,-0.03311002,0.029325308,-0.010224154,0.034496427,-0.026364643,-0.023544589,0.06544084,-0.03773952,-0.0037050056,-0.029700497,-0.06686554,-0.055895183,-0.019350018,0.07237342,0.010541085,0.0036337506,0.047414653,-0.02716163,0.023966512,-0.026461788,0.06497478,0.065642804,-0.009372618,-0.026527239,-0.07685462,-0.05212665,-0.009422061,-0.11050468,-0.00290318,0.0077490476,-0.043456927,-0.01769862,0.013766763,-0.02191122,0.06544014,0.09449716,-0.059284195,0.023944698,0.039421916,-0.05407465,-0.124195985,0.104112335,0.051299706,-2.3671028e-08,0.04814835,0.0009354452,0.047089193,-0.055868156,-0.043172136,0.063691996,0.06691356,0.034161832,0.058311056,-0.10069302,-0.025848394,0.103245385,0.0152092585,0.02266855,-0.031840056,0.025043871,-0.05004737,-0.0013595108,-0.001538444,0.0072634183,-0.13766162,0.016388604,-0.06130016,0.026182374,-0.047675777,-0.009650541,0.15794973,0.082398,0.018589644,-0.04014422,-0.032694444,0.05135439,-0.019461522,-0.06456087,0.056495547,0.043310296,0.00868687,-0.025198953,0.020956576,0.030020649,-0.04125275,-0.013195598,-0.014921392,-0.01000101,0.060436055,-0.037314516,0.009587642,0.0033595765,-0.033444162,-0.0100767445,-0.0131062595,-0.013346881,-0.036775365,-0.08286657,-0.008060738,-0.020091133,-0.045800716,-0.08673509,-0.070821926,-0.04058437,-0.03243822,-0.010893059,0.1216757,0.026540034 +3.2.1.52,Acts on N-acetylglucosides and N-acetylgalactosides.,384,1.0,-0.07560231,-0.10273058,-0.06118431,0.010234744,-0.04974107,0.025013294,0.010650702,-0.010627004,0.06467302,-0.03120023,0.015556741,0.06567181,-0.09791421,0.03650472,-0.060731255,0.031736508,-0.011273836,0.042630136,0.020029819,-0.058376122,0.041030057,-0.060073167,0.005954432,-0.028399082,0.061682146,0.041472763,0.02939644,-0.019922068,0.024866378,-0.07406749,0.006847932,-0.025158267,-0.010369412,0.001396612,0.07539495,0.03774475,-0.05721559,0.021275291,0.062131967,-0.017626362,0.0151308365,-0.057646137,-0.010891427,0.0042834138,0.018686008,-0.07059169,-0.07490726,0.06432713,0.027028369,0.07147317,-0.020906396,-0.055053584,-0.006636377,0.004590103,-0.017013503,0.058264412,-0.18506008,-0.0388572,0.0786233,0.03438531,0.058771398,-0.008054457,-0.036584616,0.028937992,-0.034586966,0.028117495,0.09015043,-0.07665299,-0.0391438,0.062223,0.015215692,-0.0056013255,-0.06248648,-0.009535502,0.06680866,-0.025026388,-0.071380585,-0.03168235,0.035874072,0.007656967,0.02546557,0.08313638,0.008313446,0.08903324,0.05159014,0.028137838,-0.0153500065,0.033087242,0.013014926,0.021992678,-0.029737009,-0.101022124,0.04313562,-0.019092454,0.00044692133,-0.005098289,0.032060333,0.032059267,-0.0074956794,0.0072259414,-0.0039072596,0.054451246,0.006689294,-0.035882488,-0.05781866,0.091066964,0.008597697,-0.008367031,0.012657773,0.058589764,-0.039940853,-0.022286864,-0.0038994364,-0.065850526,-0.10339555,0.051202957,-0.055132378,0.003181328,0.041244056,-0.019225648,-0.0057124957,-0.047689516,-0.0040667546,0.048447374,-0.019745378,0.12238714,0.039868545,2.0755377e-33,0.06771581,-0.017330868,0.009802895,0.044287413,0.06828491,-0.04105162,-0.023341186,-0.04502013,0.02311408,0.0017213454,-0.05518677,-0.016824763,0.04591819,0.009546847,-0.0060282475,0.078033306,0.0042586694,0.0094254725,0.045224756,-0.005880644,-0.037742198,0.10022625,-0.041961413,0.027981522,-0.064993165,-0.00011616767,-0.10120319,0.0642718,0.04084565,-0.014630276,0.034140658,-0.02698973,-0.035480935,0.038404,0.0075014816,0.08256502,-0.05522662,-0.05156361,0.066187,0.01301571,-0.032257855,0.09046891,-0.05052324,-0.008676107,0.012313688,-0.026149176,-0.044839554,-0.00083927286,-0.04204196,0.058116212,0.046290677,-0.025585216,0.043047093,0.002587854,0.00020398958,0.024209978,-0.039462656,0.009120678,0.011674284,0.03235968,0.011181896,0.0035990379,0.06602923,-0.05130981,-0.017750492,0.02592888,-0.07183941,-0.0036187368,-0.014588719,-0.043753043,-0.01504399,-0.023231667,0.02977068,0.012017893,0.052225735,-0.037865974,0.024289243,0.043811005,0.016509082,-0.0011803336,0.022034828,-0.039902978,0.07728471,-0.003980483,-0.061595585,-0.010997932,-0.0056669824,-0.12810299,0.007397013,-0.011663158,0.019211093,-0.04531952,-0.06017884,0.059055336,0.05774078,-3.753278e-33,0.07834439,-0.08716112,0.04589733,-0.044342265,-0.16248524,0.048746184,-0.018171398,-0.065611534,0.015841346,0.039445788,0.07732876,0.0044171857,-0.037412368,-0.047299035,-0.0025199624,-0.050185267,0.051944524,0.045886338,-0.019191131,0.031590015,-0.07408803,0.13536403,0.013512432,0.059903976,0.015450684,-0.017168123,0.014173736,-0.033291724,0.033711895,0.031797048,0.016184382,-0.05198068,-0.04801127,-0.0120565295,0.0486532,0.00720972,0.07229594,0.06543373,-0.08880545,-0.067969814,0.048570942,0.004977674,0.052992303,0.08794483,0.079228036,0.013471316,-0.041857872,-0.027640995,-0.12344305,-0.040039048,-0.019668827,-0.0034694895,-0.06002129,0.03600959,0.054890946,0.13368838,0.047276743,-0.012330522,0.0622061,-0.06331057,-0.0752439,-0.0145551525,-0.020413922,-0.040206812,0.07107342,0.033356227,-0.13092545,0.06440374,0.036539305,-0.036062524,-0.06466292,-0.0071524936,0.010531075,0.041520093,-0.05391329,-0.09237558,-0.0086021125,-0.16487104,-0.027082207,-0.11921787,-0.028659165,-0.047239922,-0.04307452,-0.04603422,-0.03873099,-0.026731357,0.07796265,0.038326867,-0.04312566,0.09435102,0.0711266,-0.012394321,-0.044727862,0.017974721,-0.0170925,-2.5201459e-08,0.06324205,0.03727876,0.008197837,-0.073390044,-0.039776247,-0.053838093,0.0016913848,0.06193371,0.028956804,-0.033928044,-0.034216274,0.11920093,0.04272761,0.040700268,0.031525582,0.061058875,-0.017568648,-0.04829544,-0.022261932,0.003037109,-0.10073683,-0.018527899,0.025354605,0.020878643,-0.03333765,-0.082352035,0.15838972,0.066258885,0.020330617,-0.003668564,-0.03554994,-0.00068563165,0.017493485,-0.088135496,0.061305437,0.02210644,0.04482275,-0.03884805,0.020887336,-0.01808082,-0.05897408,-0.029576309,-0.014990015,0.037188992,0.0089877825,-0.020895764,0.005229547,0.0022582768,-0.020260755,0.07984431,-0.010386054,-0.06653416,-0.01434738,-0.061069038,-0.087332316,-0.0582972,-0.002459347,0.017899424,0.11005636,-0.0074907253,-0.017046778,-0.0054101227,0.08521227,0.007269564 +3.2.1.54,Also hydrolyses linear maltodextrin.,384,0.99999994,-0.03175574,-0.086725675,-0.0063677486,0.060474224,-0.034925606,-0.034226064,-0.031026943,0.050251037,0.04589453,-0.08594382,-0.0037128953,0.055495735,-0.11068553,-0.0012442006,-0.11163554,-0.019033978,-0.040598642,0.09896327,-0.017340697,0.042005707,0.08374654,0.04576158,0.0062091798,0.048774753,0.038393646,0.046051834,0.030802216,0.06754188,0.0666859,-0.066186935,0.08475229,0.034086697,-0.01995759,-0.043077365,0.010025191,0.09286646,-0.033794783,-0.04361514,-0.006402211,-0.082456745,0.044844758,-0.07331404,-0.007161039,0.042554036,-0.020958487,-0.086782835,-0.109083354,-0.008033538,0.07987884,0.053390462,-0.0073723714,-0.101021424,-0.079405926,0.048217077,-0.010025881,-0.042414065,-0.09419064,0.008003701,0.06715488,0.02977726,0.004158558,0.13929544,-0.06437818,0.052930795,0.0070806434,0.05511999,0.0050050113,-0.050105993,-0.025723314,0.026133396,0.0043444484,-0.07947039,0.06619226,0.052518684,-0.030227495,-0.0112532275,-0.004419816,-0.09581131,0.03172929,0.04207259,-0.017296586,0.086081736,0.044808276,0.09886378,-0.007761651,-0.014283788,0.042886913,-0.036447722,0.031210016,0.013310157,0.02918008,0.04445299,0.018632151,-0.034005173,0.0036992352,0.011944261,0.017401895,-0.065836266,-0.0010745481,0.0025033792,-0.07720622,-0.012086247,-0.027491873,0.00198613,-0.028629383,0.04439429,0.033343058,0.007260458,0.088091925,-0.059364166,-0.07771984,-0.0011526494,-0.020740561,-0.014528083,-0.043139637,-0.002246345,0.024743125,-0.027010847,0.03945223,-0.046617333,0.00782872,-0.032520615,-0.004410288,-0.014981351,-0.04106016,0.03887309,0.024840986,1.1094445e-33,0.02130372,-0.06890953,0.028393308,0.034170147,-0.04257213,-0.0035750107,-0.07726177,-0.015397725,-0.007571164,-0.05411933,-0.09473893,-0.043146938,-0.06347892,0.0538051,0.033321284,-0.06507743,0.03783971,-0.0031215164,0.07962622,-0.0071549495,-0.041463718,0.05898437,-0.005981994,-0.021148901,-0.029221078,0.032256022,-0.010932216,0.04491378,0.093279816,0.015778024,0.06348703,0.020871397,-0.041356772,0.024646897,-0.051742606,0.14344352,-0.040289957,-0.013828728,0.08304093,0.11286349,0.06591549,-0.0072095757,0.015022002,-0.07092536,0.038849022,-0.015646053,-0.053852547,0.028124439,-0.010016975,0.0078009223,0.007366774,0.029107198,-0.044534516,0.03517944,-0.0051735914,0.05158547,-0.026064318,0.066637665,-0.004119793,0.080376305,-0.050910547,0.05841015,0.055389594,-0.038248286,0.025654608,-0.009952621,-0.004630475,-0.059333023,-0.08350383,-0.050052665,-0.14319375,0.07857309,0.120801255,0.003670404,0.027228633,-0.03576622,0.04865815,0.011746164,-0.025314653,-0.0027573996,-0.032710128,-0.06255347,0.042771626,0.006955973,-0.050060734,0.039800357,-0.06015312,-0.01244213,-0.047127854,0.0061752363,0.028223913,-0.101468876,-0.04100676,-0.0014386516,-0.06704094,-2.5744382e-33,0.046635136,-0.11778981,0.044537894,0.03553185,-0.017386328,0.06704494,0.04495263,-0.034617726,-0.049232367,0.011597305,0.08628357,0.056692258,-0.040754538,-0.060707815,-0.0044279997,0.10487055,0.028905215,0.0417846,-0.01911946,-0.041951615,-0.033985686,0.14829065,-0.011063384,0.05458926,0.086397894,-0.013655142,-0.0023936552,-0.0020535195,-0.056264833,0.051264174,-0.0023118025,-0.04039841,-0.04635395,-0.09990989,-0.028821778,0.064967334,0.0048960587,-0.08787415,-0.06996922,-0.010923752,-0.03479862,-0.001966897,0.039700035,0.04195639,0.074972324,0.06486076,1.07120795e-05,-0.041623466,0.03792244,0.08748509,0.033881906,0.037316114,-0.06459749,0.07039606,0.020042371,-0.021494765,0.0358178,-0.03499773,-0.0005656551,-0.0077694072,-0.08141952,0.01512657,0.01606932,-0.093398795,0.04211284,0.064088464,-0.028276112,0.033989448,0.02863536,-0.020440446,0.0991358,-0.061400007,0.02676573,0.027178742,-0.035272367,-0.04400047,0.039327618,-0.061930418,-0.04955247,-0.048755266,0.046101432,0.045398455,-0.01249093,-0.048055068,0.0045091584,-0.052362006,0.021467436,0.059278704,-0.014810989,0.031940456,0.002137407,-0.00407122,-0.032787174,0.0022375935,0.15117493,-1.6966126e-08,0.028940408,-0.044138797,-0.022960668,-0.018929578,0.04288465,0.03628613,0.012999884,0.047816176,-0.019992065,-0.055610646,-0.019653369,0.079499766,-0.05971095,0.013904235,-0.008839767,-0.020706462,-0.03902038,0.04334113,-0.05329498,-0.0525426,-0.13823082,0.033645496,-0.054031316,-0.019780878,-0.012611343,-0.09982388,0.06629633,0.026032705,0.06450282,-0.008737521,0.039561696,0.06570467,-0.017589815,-0.03594765,0.021172086,0.07360146,-0.044607427,0.0068676034,-0.024412952,0.0779492,-0.0174192,-0.017011125,0.018291293,-0.021641402,-0.050324865,-0.0013432173,-0.009186902,0.02927155,-0.014413156,0.0025062743,0.052478146,0.018887382,-0.01930336,-0.029923717,-0.035947364,-0.004347596,0.018987328,-0.06918817,-0.041420605,-0.03651862,-0.05722405,-0.023806361,0.1416176,0.02863698 +3.2.1.55,"The enzyme acts on alpha-L-arabinofuranosides, alpha-L-arabinans containing (1,3)- and/or (1,5)-linkages, arabinoxylans and arabinogalactans. Some beta-galactosidases (EC 3.2.1.23) and beta-D-fucosidases (EC 3.2.1.38) also hydrolyse alpha-L-arabinosides. cf. EC 3.2.1.185, non-reducing end beta-L-arabinofuranosidase.",384,1.0,0.02622025,-0.069282636,-0.063235804,-0.017510226,0.049676307,0.024441615,-0.056492608,-0.040522676,0.04514093,0.01967861,0.03943895,0.03332692,-0.04780147,-0.00415809,-0.06867704,0.047631267,-0.050555404,0.058684073,-0.0378227,-0.030027444,0.07730961,-0.033284247,-0.0020740065,0.052186932,0.049619846,-0.015963048,-0.0066776187,-0.033821303,-0.032474913,-0.08191964,0.021884175,-0.03872899,0.067932226,-0.037591938,-0.020166952,0.07682371,-0.04676935,-0.086384095,0.07902453,0.009984648,0.07537914,-0.059936658,0.058043204,-0.071037725,-0.029222507,-0.023132417,-0.00813522,0.04933801,0.10039466,0.032868464,-0.013512992,-0.1000056,-0.05507696,0.0022754017,-0.0027428507,0.0151059,-0.024226567,-0.033109114,-0.030832658,0.097973384,0.043171905,0.09182081,-0.03931224,0.033217136,-0.1031018,-0.0330749,0.040125594,-0.057004232,-0.02606611,-0.036080196,-0.017775076,-0.05598578,-0.024338715,-0.010955881,0.032229166,0.04537513,-0.0101726875,-0.03747251,-0.016200833,-0.02263446,0.022862028,-0.025703823,0.05347127,0.0053434162,0.004232309,-0.062447045,0.0132680675,0.03136156,0.051052485,0.06547808,0.08469891,-0.024402244,0.0073578623,-0.021305822,0.039079055,0.021146523,0.047830783,0.010008997,-0.025423735,0.007853912,-0.040970143,-0.040871218,0.03227631,-0.08436997,-0.066973165,0.066911735,-0.045749832,0.044586226,0.027304728,-0.06220881,-0.044059556,-0.033258997,0.03840559,0.0070045935,-0.04720746,0.03156623,0.020194275,-0.10792864,0.010197309,-0.02982362,0.03399436,-0.039161198,0.12941214,0.029939052,-0.0033935425,0.08393423,-0.091502175,-4.742381e-34,0.049066886,0.032945268,-0.0010234994,-0.045319982,-0.020397782,-0.005794812,-0.064999074,-0.010681365,-0.048015255,0.0074528567,-0.08118171,0.010602009,0.0049919956,0.04445176,-0.008858424,0.041023217,0.06810651,-0.07477922,-0.00022001265,0.021862626,0.026025753,0.015566223,-0.020554034,-0.048350856,0.040730093,0.03840161,0.00869316,0.031252082,0.077157766,0.02276811,-0.040424008,-0.06494311,-0.115829155,0.048416894,0.013975993,0.08462374,-0.092233494,-0.06926814,-0.034997564,-0.0012146067,0.019543627,0.0059198146,0.005833467,-0.024620388,0.05266151,0.011719719,0.002938056,0.0436099,0.06254902,0.07415339,0.053105727,0.01634246,0.065298,-0.008810479,-0.024169106,0.024819277,-0.049794365,0.04684779,-0.042962912,0.06943934,-0.020344434,0.01264072,-0.011960919,-0.012473028,0.0025917692,0.05669411,-0.024548352,-0.008933984,-0.034323104,-0.03226576,-0.037992995,-0.043076403,0.094304934,0.026030667,0.030098578,-0.034287088,0.008177682,-0.022101738,0.018147223,0.011654088,-0.005055787,-0.004269005,0.028931234,0.039449323,-0.08463462,0.063438706,0.01634131,-0.018125271,-0.023270719,-0.027716938,0.053305004,-0.022196755,-0.0125694005,0.08955396,0.03439065,-1.5768314e-33,0.06838017,-0.10909219,0.008482673,-0.07062427,-0.04485994,0.04487561,0.10061749,-0.0010567195,0.035618592,0.003253445,0.05059423,-0.06261625,-0.03375375,-0.16194531,0.011635191,-0.025169156,0.06636432,0.024653114,-0.06501046,0.0060105943,0.0012970055,0.10742512,0.064049765,0.00024848877,0.046792306,-0.078881465,0.060413975,0.10519988,0.009702144,0.036203787,-0.0015637788,0.04952484,-0.02204668,-0.055033527,-0.04756951,0.029523548,-0.09852325,-0.005105781,0.03384379,0.016082628,0.055648025,0.0655866,0.015826523,0.05837235,0.07652754,0.12874731,-0.109262414,-0.014207839,0.024241421,-0.09011039,-0.032694187,0.008812833,0.032742683,0.09411658,0.047266267,0.029342711,0.0101895835,0.08023556,-0.00252286,-0.030648874,-0.052580565,-0.044084854,0.05735535,-0.07387964,0.04727679,0.0031702777,-0.058077015,-0.0002274753,0.047700964,0.05410275,0.04915755,-0.03400988,-0.04751433,0.051666316,0.008479878,0.022434754,-0.12445784,-0.11722447,-0.034734514,-0.04286362,0.044688795,0.052623425,-0.0640462,-0.030086283,0.063399315,-0.06905729,0.023126144,0.15279011,-0.00807767,0.04766572,0.0075486554,-0.022834457,-0.061594136,0.043917052,0.030346751,-4.2729273e-08,0.027559614,-0.036269378,0.032734778,-0.08297446,-0.017124496,0.08318946,0.019465685,0.0729659,0.00076736155,-0.054422345,-0.058204174,0.07606445,-0.004841016,0.061159633,-0.01301516,0.012820116,0.013850499,0.04252197,-0.012331067,0.010908212,-0.0804254,-0.02372189,-0.12039211,0.011224954,-0.029694067,-0.07962479,0.04397888,0.05459186,-0.030815851,0.016444761,-0.025318846,-0.000670558,-0.012672571,-0.07576856,-0.05931542,0.061455823,-0.064105295,-0.0009876532,-0.012495162,0.023168443,0.04036824,-0.051057693,-0.032515004,-0.015303915,-0.0020781106,-0.05123144,-0.03146539,0.055094976,0.009072851,0.040517937,0.123971686,-0.039221298,-0.100727834,-0.07258593,-0.047306977,-0.068689056,0.014118035,-0.06239419,-0.043549724,-0.031800356,0.0048193303,-0.06957913,0.13764831,-0.030019483 +3.2.1.57,The enzyme has practically no action on starch. Panose (4-alpha-isomaltosylglucose) is hydrolysed to isomaltose and glucose. cf. EC 3.2.1.41 (pullulanase) and EC 3.2.1.135 (neopullulanase).,384,0.99999994,0.039534315,-0.0910486,-0.061441634,-0.018496785,-0.0035386558,0.061459918,-0.014979856,-0.023696749,0.009937653,0.026645299,-0.016425645,-0.054207146,-0.13672322,0.024415703,-0.048007954,0.017672129,0.010217661,-0.026863948,0.009711622,-0.015626583,0.07750507,-0.024642799,0.0111390455,0.042743936,0.06168096,-0.046783026,0.03122236,-0.10359113,-0.07656427,-0.060253263,-0.025452243,-0.100797206,0.027125778,0.025257405,0.03808062,0.016286997,-0.014700124,-0.1035917,0.018896775,0.019312745,0.07340211,-0.08709109,-0.00456294,-0.034523252,-0.03810362,-0.0005863155,-0.08941317,-0.07457833,-0.0045581385,0.027908647,-0.05638351,-0.11926353,-0.029388964,0.016130332,0.035170753,0.014015915,0.0030855578,-0.043921955,-0.044385877,0.06384471,0.051036403,0.020386336,-0.05184641,0.014171949,0.022930393,-0.100612685,0.016346484,-0.08129117,-0.035550676,-0.035572156,-0.07709655,-0.0514298,0.007893446,0.043356158,-0.005700656,-0.06862437,0.030160239,-0.033795476,0.07726974,-0.037725993,-0.004303992,-0.0034946578,0.017697921,0.056511533,-0.040110346,-0.003479429,0.016379531,0.05921226,0.028942809,0.0066215945,0.043075122,0.024779318,-0.054355297,0.016959518,0.013484237,-0.01607803,0.005564852,-0.045459285,0.07760558,-0.05439857,0.012356337,0.07125766,-0.025441099,-0.09043349,-0.05654216,0.081953175,0.054662123,0.04285853,-0.01710439,0.08311025,0.0293709,0.021492202,0.07782874,0.022017354,-0.07884774,0.044219837,-0.0016324336,-0.0934353,-0.03893666,-0.040582556,0.017530872,-0.025297273,0.12463443,0.08038369,-0.069750465,0.10083556,-0.010088923,1.2937743e-34,0.055472653,0.047526564,0.030466832,-0.023558185,-0.040553354,0.007272371,-0.039863013,0.009642093,-0.04712722,-0.0036564595,-0.062300146,-0.014057115,0.030291677,0.08021206,0.05072514,0.02979376,0.053856857,-0.06091363,0.05722162,0.0033637977,-0.021086698,0.10712505,-0.04001785,0.008359657,0.035490975,-0.015114301,-0.06683366,0.010411827,-0.022757504,0.0051397653,0.08232621,-0.0179884,-0.00034930895,0.08952324,0.060865723,0.025245197,0.0048572687,0.022647573,-0.029353235,0.008020369,0.036799178,0.016162446,0.011100315,-0.068049476,-0.009101797,-0.06098516,-0.048194867,0.08626892,0.055982515,0.037592243,0.067537576,-0.01995807,0.047279842,0.033294294,-0.00036986376,0.089707635,-0.0034667652,-0.0029471638,0.041815184,0.048969705,-0.031979393,0.091491826,0.0054254904,-0.022353435,0.018186696,0.08606475,-0.056663703,0.008367621,-0.07717458,0.030049562,-0.0981943,-0.009036631,0.061808117,-0.013286065,0.012886336,-0.08371429,-0.03928699,0.038198788,-0.03618236,-0.0040088915,0.07361061,-0.049776014,0.04796009,-0.025963962,-0.06567157,0.013192126,-0.010557585,0.046403613,-0.024829183,0.021933023,0.05561519,-0.013122064,-0.01610186,0.037327345,-0.003132433,-2.090726e-33,0.08056725,-0.09053408,-0.01096022,-0.0044024144,0.011764596,0.041671924,0.006529529,-0.09473356,0.03133991,-0.010378855,0.043659043,0.016340248,-0.015736492,-0.08081895,0.061273746,0.025205059,-0.06676751,0.057652283,-0.08320122,-0.036767997,-0.046161175,0.08929757,-0.03227236,0.05776414,0.073460646,-0.035354566,0.035422865,0.08308422,-0.0026226526,-0.024674281,0.055462822,-0.055752862,-0.0054533985,-0.042711355,-0.05891945,0.024350058,-0.03595949,0.053542074,-0.025351116,0.022316897,-0.04933586,0.03994074,-0.0053710598,0.059811395,0.035735443,0.08538782,-0.096850395,0.0023358832,-0.070369184,-0.010683515,-0.00721612,-0.015799217,0.049255367,-0.010959132,0.05533415,0.07829497,-0.0018675666,-0.03082799,-0.014623503,-0.05665929,-0.02557842,0.012570489,0.066019624,-0.014040019,0.08967512,-0.039481323,-0.10294644,0.046054635,0.0022102585,0.018527048,0.024345206,-0.011923299,-0.012917805,0.0573317,0.011355232,0.020126076,-0.09823863,-0.043646127,-0.010767861,-0.029760206,0.05472419,0.039657116,0.08463444,-0.09190454,-0.025592932,0.008031363,-0.00024936,0.08803387,-0.032721467,-0.011752737,-0.034061667,-0.0009095752,0.023684718,-0.0311967,0.08891673,-3.828364e-08,0.061378486,-0.054038025,0.04775619,-0.033852134,-0.04815075,0.040411726,0.081505135,0.02296862,0.06228654,-0.021413306,-0.113797285,0.10139524,0.014301625,0.0291652,-0.04654654,-0.05151154,0.03124021,0.014777951,-0.035073873,0.07363313,-0.106724806,0.018366063,-0.09732496,0.018438313,-0.039501373,-0.04884946,0.034271326,0.1018338,-0.0488576,-0.0076056193,-0.021274157,0.069404766,0.04754111,-0.026360504,-0.08381932,0.09230226,0.024334691,-0.02353297,-0.02722944,0.057820156,0.079752624,-0.069194146,-0.017708074,-0.037846092,-0.098576516,0.010869102,-0.007956341,-0.0712205,0.04910608,0.011955366,0.01964913,0.04734346,-0.12649009,-0.005804637,-0.026401283,-0.021122806,-0.044619314,-0.024811644,0.0060389247,-0.01862492,0.0856411,-0.07959153,0.14524367,0.0031958052 +3.2.1.58,"Acts on oligosaccharides, but very slowly on laminaribiose.",384,1.0,-0.023676444,-0.106503434,-0.08646264,0.039233625,-0.008164935,0.010618958,-0.0354246,-0.01888876,0.09581294,0.008508452,0.031917486,-0.031661853,-0.07096711,0.07166882,-0.08670617,-0.018888228,0.019035969,0.018632885,-0.03783209,0.053692933,0.051928893,0.00082665065,-0.004545164,-0.0077218423,0.00025776224,-0.030476797,-0.018235404,-0.042473886,-0.014373999,-0.08820101,0.039572913,-0.00088370655,0.047017526,-0.03918354,0.08758777,0.053336963,-0.023296414,-0.0067961263,0.050928485,-0.06100546,0.107414134,-0.03617934,0.024779651,0.02825679,-0.00054048165,-0.06246833,0.038195465,0.026882946,0.035785884,-0.03262248,-0.121739775,-0.09953508,-0.06712399,-0.00523585,0.030477298,0.095206246,-0.05494666,-0.023396153,0.06806822,0.02739512,-0.026724806,-0.021315832,-0.02768524,0.04818807,-0.015154006,-0.03825044,0.054971106,-0.052777525,-0.03211583,0.06992206,0.0065344763,0.07442673,-0.0041540787,0.06333077,0.06935758,0.01757293,-0.029179003,-0.06565304,-0.007969727,0.014643698,-0.031862088,0.013051808,0.0407915,0.047041524,-0.021974465,-0.021432048,0.041694526,-0.036359314,-0.024044242,-0.0041312827,0.059635445,0.033207756,0.014550064,-0.04267957,-0.08097235,-0.08205902,0.04115911,-0.0019002571,0.038980488,-0.042608496,-0.07511028,-0.044771146,-0.0056326254,-0.03921394,-0.077389576,0.058255903,0.052379392,0.04026108,0.003934274,0.06052882,0.0048047174,-0.0229334,0.0020987496,-0.02056513,-0.09282232,0.05178735,0.12504293,-0.07599885,-0.061402954,0.03304839,-0.031648505,-0.052944623,0.10535333,-0.017249942,-0.103293665,0.10953899,-0.003998598,-6.0350064e-35,0.051792104,-0.10690201,0.029657833,0.0043206722,0.023321668,-0.0039612153,-0.010708437,-0.07662456,0.020427447,-0.021111062,-0.0019546545,-0.075424656,-0.00047835437,0.1335325,0.0244306,0.035429183,-0.01992742,-0.09362179,0.015081871,0.011485775,0.044624075,0.10770558,0.021134622,-0.048194654,0.05045875,-0.04815523,-0.056762714,-0.042102996,0.050540607,0.032969285,0.13106441,-0.051791593,-0.13732898,-0.026963063,0.05572484,0.13347788,0.0021258502,-0.025272796,0.02328025,-0.008482618,-0.074275926,0.0045146993,-0.039371293,-0.0762658,0.017264673,-0.059856582,-0.014273563,0.049659543,-0.00065485074,0.10091807,0.08318855,-0.014094698,0.023071555,0.027558986,-0.023061438,0.006663865,0.0096004205,-0.069506705,-0.011900847,0.0481115,0.00878168,-0.0014179116,-0.04554655,-0.053149078,0.024511583,0.06519433,-0.06122868,-0.004723725,-0.020257639,-0.02304619,-0.07436868,-0.046622302,0.0107056415,-0.04403156,-0.041424703,-0.020178558,-0.09840014,-0.011122229,0.0049796733,-0.022640146,0.085929826,-0.011243319,0.046894316,0.021305267,-0.045688238,0.049159944,-0.007933643,0.0189668,-0.01982953,0.06700706,0.069568686,-0.023879088,-0.03313742,0.030827219,-0.012716687,-2.8028285e-33,0.09654674,-0.07702392,0.06861178,0.042578198,-0.030179067,0.014330916,-0.028153613,0.07671264,-0.025475394,-0.07797296,0.0310027,0.012622962,-0.0005261467,0.007358034,-0.0011461322,0.007937458,-0.0016473894,0.06604099,0.022580292,-0.022855213,-0.10916659,0.070914075,0.06622634,0.019868093,0.10551556,0.026421938,0.022697117,0.023945568,-0.035483614,0.033183835,-0.04675008,0.023928696,-0.07797708,-0.0843699,-0.05883086,0.08935725,-0.04377372,-0.04956406,0.021632964,-0.049890205,0.034083363,0.004136493,0.036720928,0.001967782,-0.0034483788,0.07229483,-0.039599452,0.037046887,-0.06158569,0.010290001,0.008592367,0.008654527,-0.026559211,0.05041257,0.059720006,-0.0034433228,0.079716414,-0.059915468,-0.006087924,-0.07147265,-0.058231823,0.020399194,-0.015092025,-0.052043818,0.13449295,0.0907978,-0.04038404,0.016599607,0.062537305,-0.045073587,0.014366754,0.016100818,-0.030501965,-0.0012463131,-0.012711823,-0.003203872,-0.12333683,-0.020537052,-0.014206188,0.024530992,-0.020533672,0.019568434,0.020078385,-0.08731952,0.020681975,-0.026818203,-0.008078492,0.001875816,-0.0029411379,0.08901275,-0.014592531,-0.05134324,0.024714362,0.021247828,0.08982193,-2.1221695e-08,0.03170006,-0.018322926,0.045519892,-0.04609705,-0.058070775,-0.017202737,0.048497178,0.029392112,0.0524375,0.035059318,0.040224433,0.13753037,0.072629616,0.06457224,0.0034739757,0.009614703,-0.03673516,-0.06758791,-0.022236029,-0.06606195,-0.13804518,-0.0057527865,-0.040490426,0.07592817,-0.052583594,-0.11209575,0.022900503,0.033003088,-0.043070037,-0.05014797,0.0030650273,0.039235078,-0.0019851008,-0.040188838,-0.04893643,0.01630287,-0.028970364,-0.04210152,0.012176049,-0.0195519,0.0056655924,0.02010268,-0.06470867,-0.03805963,-0.0041343216,0.0112445485,0.033209022,0.06933766,-0.056254376,-0.028807145,0.039412502,-0.008098576,-0.0027465099,0.0340479,-0.11579975,-0.031238195,-0.021341458,-0.012177615,0.041855555,-0.022546161,-0.005589946,-0.030121667,0.08773713,-0.04071684 +3.2.1.59,"Products from pseudonigeran (1,3-alpha-D-glucan) are nigerose and alpha-D-glucose.",384,0.99999994,-0.04551205,-0.08479306,-0.09411921,-0.021461265,0.026264844,-0.011324855,0.014979813,0.037429668,-0.020811886,0.029935863,-0.00064747187,-0.0071987454,-0.033989057,-0.031283516,-0.07685543,-0.041424055,-0.023838121,-0.005311403,0.020196104,-0.004291145,0.120913625,0.06369377,0.06435029,0.022179544,0.063496284,-0.019322611,0.027911484,-0.044835772,-0.013394745,-0.05568659,-0.0328548,-0.05695634,0.050355,0.008690716,0.040598206,0.03627063,-0.044468533,0.047531918,-0.031126915,-0.020328538,0.039824482,-0.027930958,0.0056007043,0.022757528,-0.0065616504,0.051727455,-0.1335079,0.10187918,0.035505462,-0.021500058,-0.035423014,-0.051410995,-0.101482,0.07646378,0.07434859,-0.026192287,-0.058620773,-0.059606567,0.03781589,0.07700157,0.015265096,-0.014155428,-0.061542615,-0.055848423,0.0056794756,-0.0016526375,-0.008608083,-0.05350226,-0.03642226,0.014820133,0.026085593,-0.016546115,-0.020505536,0.03058941,0.0054271207,0.012770592,-0.019128509,-0.024783872,0.012100851,-0.017409895,0.033534028,0.019958882,0.1017141,0.12564734,-0.042248957,-0.036206577,-0.011434323,0.023424935,-0.03471995,-0.0058645885,0.036870446,0.022029404,-0.037384965,-0.0052107284,-0.043656904,0.029765697,0.039427325,-0.0077343653,0.078704834,0.0109345075,-0.007986344,-0.03748598,0.027658984,-0.06652083,-0.12961592,0.055651583,-0.034218762,0.0021520057,0.083326,0.036592342,-0.03011183,0.051223546,-0.06110634,-0.0016662318,-0.18619788,0.0043762396,0.031929325,-0.052869186,0.010398184,0.0014658903,-0.039085794,0.061881486,0.07322017,0.03621281,-0.038843337,0.028110724,0.030060012,-3.8397233e-33,-0.002765815,-0.019982953,-0.008333614,-0.06776143,-0.07426988,0.028303811,-0.13475819,-0.056395587,0.035523046,-0.007178385,-0.10774042,-0.02953704,-0.07140939,0.09545429,-0.0376314,0.035953835,0.024405485,-0.06667167,0.050499942,-0.015495448,-0.019202836,0.103128195,-0.02652378,0.02462601,0.0750087,-0.029107641,-0.060256585,0.04020551,0.061075967,0.008898215,0.0648852,0.026903296,-0.04373055,-0.03575194,-0.061852828,0.026164107,-0.040158894,-0.08686079,0.0037733861,0.10380708,0.06521488,-0.0060386485,0.033667885,0.02575675,0.025798412,0.0099329455,0.015617649,0.02557687,0.013735815,0.068545654,-0.010197996,0.018580696,-0.0045320564,0.05779374,-0.030268617,0.004885477,-0.007697377,0.021244112,0.07457393,0.038854692,0.016904969,0.11079726,0.0464117,-0.041925006,-0.018587677,0.00926227,-0.091398135,-0.0006596585,-0.030592987,-0.07498627,-0.043721206,-0.05439247,0.0689895,-0.019793734,0.0242347,-0.011595495,0.026208444,0.034217,-0.024200602,-0.021828094,0.011657824,-0.015250728,-0.028701752,0.0071298736,-0.19038802,0.04648742,-0.049639516,-0.084064804,-0.025164625,-0.008078729,-0.041140996,-0.0041202027,-0.11348435,0.071894154,-0.058662258,1.5997455e-33,0.05857826,-0.08240982,0.06890285,0.04477525,0.024536636,0.020406533,-0.020632884,-0.07515077,0.023066487,0.0032405956,0.06897156,0.061594833,-0.055913568,-0.060380932,0.026557865,0.05180436,0.059557,0.11071697,-0.04571087,-0.020648586,-0.02763499,0.13473162,-0.040227853,-0.0078063165,0.04820108,0.025005713,0.06909201,0.05164973,0.0425683,0.02884151,0.096920654,0.0063055255,0.016797768,-0.016529199,0.016498148,-0.008810025,0.033111256,-0.03585067,-0.019338824,0.0018485754,0.023663826,0.107747786,-0.0015372464,0.018005436,0.092529066,0.02435708,0.018640706,0.020730043,0.014848879,-0.004779654,0.042031866,0.050480727,0.007239331,-0.020087568,0.028326947,-0.021631112,0.030319003,0.033343147,-0.025393222,-0.045228973,-0.015638333,-0.0432872,0.06328121,-0.10238627,0.07134241,0.026679227,-0.012135833,0.03361357,0.086093,0.1031227,-0.017641693,0.0028130028,-0.02206677,-0.00084448804,-0.0248759,0.061995722,-0.0018974785,-0.010275158,0.007365559,-0.0404126,0.020188484,0.05979283,0.037934728,-0.018634504,-0.021798955,0.0010244738,0.006337224,0.045608837,0.0024549272,0.07566167,-0.053966295,-0.018536672,-0.011946933,0.059606954,0.09390917,-2.4411317e-08,0.12435905,-0.00889785,-0.002925459,0.017337728,0.019277351,-0.049651638,-0.016129103,0.024949497,0.0074486802,-0.036810838,-0.07157161,0.105588846,-0.05020333,-0.04285363,0.055252604,0.008372477,-0.030515164,-0.03615678,-0.022055214,0.05265116,-0.058317874,0.007716277,-0.10107704,-0.056853864,-0.09362673,-0.112059444,0.08762087,-0.03067017,-0.037459858,0.02902889,0.0059837485,0.07161444,-0.011540674,-0.057794318,-0.010969534,-0.028857019,-0.045286067,0.012028643,-0.02498498,-0.021873834,0.04464042,-0.056242846,0.02416654,-0.007035549,-0.12171836,-0.074019685,-0.0040030023,0.011270342,0.012424021,0.025633259,0.032233294,0.034172956,-0.08558745,0.0058669513,-0.05785619,-0.0637037,-0.042033397,-0.040641427,0.0077528604,-0.058629375,-0.029951649,-0.08228444,0.1170109,0.039656624 +3.2.1.60,"Compare EC 3.2.1.2 beta-amylase, which removes successive maltose residues, and EC 3.2.1.98 (glucan 1,4-alpha-maltohexaosidase) and EC 3.2.1.116 (glucan 1,4-alpha-maltotriohydrolase).",384,0.99999994,0.024802802,-0.04779366,-0.026151046,-0.032525472,0.0351372,-0.008636633,-0.010909023,0.014887337,0.085573986,-0.06671916,0.0029529815,0.055351995,-0.084732294,-0.015736712,-0.0472455,-0.031888455,-0.021595765,-0.036319114,0.025290603,-0.07231236,0.087080225,-0.009309771,0.00012393737,0.07165345,0.065917276,0.03553209,-0.013724757,0.013764565,-0.023556195,-0.111027315,-0.0487254,-0.09573242,0.09144789,-0.006387655,0.005346572,0.003949216,-0.047913667,-0.044666935,-0.0528826,0.0123130595,0.03040862,-0.016690906,0.013030896,0.008281899,-0.0951272,-0.048697352,-0.09760691,-0.021849845,0.0069099795,0.016556995,-0.031774495,-0.114706114,-0.060429543,0.07901101,0.069770426,-0.048484623,-0.04352782,0.017906811,-0.041303452,0.07813198,-0.016598606,0.12524447,-0.027561126,-0.034759074,0.0030460544,-0.050821688,0.06438643,-0.15496589,-0.027178181,0.011256324,-0.09974086,-0.080295935,-0.013707801,0.025661232,0.04384889,0.005362518,-0.03672591,-0.0259987,0.002098649,0.02681722,0.034501486,-0.041236363,0.004538384,0.059850182,-0.06987878,-0.07588842,-0.016020197,-0.01226702,0.03629963,-0.031401265,0.10065062,-0.045480568,0.035990935,-0.012766784,0.08887146,0.039096706,0.005425397,-0.027479745,0.06192985,-0.033136457,-0.01895996,0.03176173,-0.0062077357,-0.07490444,-0.06060905,0.10444999,0.01063512,0.07184426,0.04164193,-0.02619681,0.008845873,-0.03414299,0.040679403,0.0041864533,-0.08990308,0.058775093,0.021865586,-0.040309362,0.029158771,-0.0005453528,0.04610921,-0.011924255,0.14410305,0.04160522,-0.0063422713,0.10064437,-0.09291136,2.3996076e-34,0.040211286,0.0033421435,-0.014789565,-0.056707077,-0.026295424,0.031297177,-0.066916116,0.03508082,-0.010987054,-0.0147044305,-0.08027694,0.004785866,0.008943495,-0.0002312813,0.033231698,0.0073685334,0.028264292,-0.027502563,0.048884016,0.05523047,0.027759038,0.061413836,-0.008950361,0.0014164794,0.08425928,0.040259026,-0.045048654,0.026025603,0.019204853,-0.008027563,0.016222049,-0.008135684,-0.13057101,0.067620926,-0.0024582162,0.051103085,-0.046492215,-0.027757045,0.03667817,0.026354028,0.050725996,0.04871676,0.060415,-0.08647405,0.054576747,-0.035677336,-0.044519983,0.07779019,0.04448472,0.07363874,0.034841966,-0.004788872,0.016718116,0.019671313,-0.029787766,0.040528003,-0.004518227,0.045152616,0.041215435,0.04186527,-0.014125114,0.08341848,0.031167084,-0.0718474,0.023980184,0.033145126,-0.03164294,-0.0138166435,-0.08819609,0.031005574,-0.08087881,-0.014506807,0.08983368,-0.044306148,-0.0011600052,-0.09182903,-0.09536396,0.015556705,-0.008561298,0.011891309,-0.007044496,0.0141796395,0.04959708,0.022253495,-0.072794646,0.01603115,-0.023238977,0.030250184,-0.026701348,0.021263812,-0.010935621,0.007859831,-0.013752022,0.07291186,-0.037891388,-1.8834338e-33,0.13407187,-0.15048577,0.062478308,-0.020932138,-0.0088770585,0.03369858,0.0929517,-0.052139923,0.01079169,0.0065302737,0.09301502,0.022600433,-0.015006152,-0.10493234,0.046656616,-0.007958255,-0.08580575,0.012188334,-0.009191785,0.010056028,-0.0052542095,0.14535342,-0.020035107,0.015503779,0.008697845,-0.08835114,0.048678234,0.04044013,-0.011156705,-0.04315287,-0.02366647,-0.008726122,0.015371087,-0.07610225,-0.05742606,-0.005666061,-0.029376036,-0.018942406,0.009881189,0.019994806,0.036938865,0.07923424,0.033646323,0.05948404,0.08697544,0.12578282,-0.03632022,0.038228046,0.012069944,0.0056233276,-0.023307327,-0.022892442,-0.056927487,0.011635623,0.021242704,0.031036265,0.051506665,0.015345185,-0.026638748,0.031063713,-0.06924634,0.055670183,0.061359175,-0.02779032,0.035464585,0.058612812,-0.074379645,0.050471693,0.060916737,0.03820388,0.006026372,-0.09008874,0.011465398,0.021037633,0.01796558,-0.00988045,-0.075665705,-0.006945261,-0.00059826946,-0.07130776,0.05582001,0.03338523,0.0010693276,0.0009794425,-0.012579918,0.0046069548,0.006137412,0.06781379,-0.08125813,0.0076675587,-0.021816319,-0.03302236,0.028875425,0.027770536,0.090144,-3.604821e-08,0.08447288,-0.012926547,-0.0077205277,-0.025606837,0.024896389,-0.030391712,-0.051424198,0.12246462,-0.0056514535,-0.016532728,-0.05016487,0.05752306,-0.049198724,0.040071983,0.007849078,-0.011595948,-0.016024262,0.024291916,-0.013993901,-0.0010008449,-0.09033903,0.008013375,-0.09399534,-0.024374647,-0.023495581,-0.064926215,0.038641483,0.047726385,-0.0658422,0.0036335497,-0.0131122265,0.0539026,0.027815359,-0.04274817,0.017230187,-0.059691727,-0.07328032,-0.04155837,0.00980857,0.03927489,0.06767289,-0.04232902,-0.027421748,-0.06715702,-0.029953932,-0.02453171,0.033311408,-0.0532606,0.020256622,0.049317446,0.041512612,0.003450841,-0.05700453,-0.03253795,0.036767907,-0.020213833,-0.009540198,-0.09081153,0.022250414,-0.05061708,0.08835334,-0.06719202,0.16874191,-0.011902446 +3.2.1.61,"Products are nigerose and 4-alpha-D-nigerosylglucose. No hydrolysis of alpha-D-glucans containing only 1,3- or 1,4-bonds.",384,1.0,0.02201673,-0.040954694,-0.03391767,-0.03147331,-0.011728124,-0.0507553,-0.007123478,-0.02493706,0.037181295,0.012887475,-0.010174802,0.02889139,-0.042654116,0.0072667827,-0.10285444,-0.02117663,-0.003933268,0.01436809,-0.04708957,0.002931608,0.08678056,-0.022773536,0.01127073,0.02243182,0.035030127,0.013714876,0.054842744,-0.101267956,0.025214415,-0.05818252,-0.0055550695,-0.09637383,0.07660652,0.022153085,0.123444594,0.056837786,-0.015256853,0.003565656,-0.0065850345,0.004580685,0.030984657,-0.055276852,0.035976678,0.013410324,-0.032812066,-0.00987435,-0.077704996,0.023790052,0.020475661,-0.0052625025,0.06850821,-0.056910783,-0.16109742,0.05266767,0.038969412,-0.054449048,-0.122976765,-0.00926189,-0.022873024,0.12183651,0.10653477,0.042109445,-0.08603433,-0.037864204,-0.044633795,0.013514662,0.071198136,-0.010757912,-0.079753585,0.032280497,0.010080295,0.0075264224,-0.0013584404,0.0066358577,-0.022514213,0.01812101,0.00904067,-0.05401373,0.051335994,-0.036216628,0.062272854,0.015994798,0.08488231,0.06414934,-0.03856562,0.019796535,-0.081843324,-0.017694293,0.035834406,-0.0050014877,-0.0017911297,0.0072336528,0.017092085,-0.013471965,-0.0012196032,0.024540879,0.02148642,-0.0041128444,0.054427765,0.029352093,-0.026736429,0.0063349265,0.012662153,-0.08348075,-0.119491,0.047202405,-0.041796472,0.084199086,0.05396357,0.025096206,-0.047661893,0.015689196,-0.004823128,0.038192283,-0.10629916,-0.022017084,0.04904,-0.0722414,-0.060801625,-0.031363145,0.008979706,0.06479575,0.116707385,0.064628996,-0.08302326,0.03217055,0.043096825,-1.3677951e-33,0.035837937,0.015641833,-0.003833261,-0.04467018,-0.10475973,0.04100835,-0.103199854,-0.029838266,-0.025766455,0.046146452,-0.10216259,-0.022749268,0.008056521,0.08016257,0.015453173,0.04844199,0.06622024,-0.040413316,0.067417905,0.0050053773,-0.02893831,0.13012052,-0.06408383,0.059340235,0.047096387,-0.0469295,-0.056523535,0.0009981536,0.042903136,-0.020014832,-0.033884186,0.008853942,-0.028681379,0.020332579,-0.037588056,0.03423669,-0.06549512,-0.033935018,0.023585483,0.038999643,-0.029399112,-0.01673678,-0.017713213,-0.05606728,0.06194361,0.016442219,0.015514622,0.013333319,-0.018488532,0.04739234,0.026627783,0.06860756,0.01217574,-0.000321969,-0.067303024,-0.012714294,-0.0078119724,0.025208741,0.027316151,0.06059284,-0.003978665,0.13049385,-0.044961475,-0.0586602,-0.058072533,-0.049017284,-0.047560807,0.004889639,-0.029827135,0.0031778268,-0.032358717,-0.025880594,0.058928132,-0.01124579,0.037670456,-0.05131318,0.04570004,0.052553743,0.013775066,0.011944317,-0.011756196,0.012710222,0.022082748,0.016254477,-0.071370274,0.091034584,-0.049733732,-0.034447294,0.015932143,0.06206008,-0.11633779,-0.004812442,-0.10301738,0.067311294,0.0073026074,-7.280333e-34,0.09810405,-0.069214255,-0.020724064,-0.0009083182,-0.009198014,0.06867176,0.038896967,-0.035416298,0.017993923,-0.054683693,0.092573546,0.00398624,-0.09591619,-0.021447852,0.037077125,-0.0017011858,-0.0466552,0.061484702,-0.02577464,0.021985436,-0.038364436,0.119093716,-0.007604189,0.013335441,0.08034697,-0.030063838,0.08105601,0.024659544,0.03987649,0.053892028,0.041272316,-0.039904114,0.03154931,-0.025123717,-0.041900292,0.05085662,0.009102277,0.024133455,-0.031681035,-0.02518976,0.022110263,0.06829735,0.0345837,0.050456617,0.033558443,0.05272687,-0.02371401,0.03345679,-0.023353772,0.0075974227,0.010031513,0.00045331815,-0.038570978,-0.007968727,0.06035696,-0.0304241,0.06242242,-0.0051895394,-0.0592821,-0.03555428,-0.091915354,-0.023290105,0.066812016,-0.10093352,0.100462765,0.034449443,-0.019347262,0.07631337,0.03247129,0.056681216,0.014128699,-0.012789121,-0.040131256,-0.023212042,0.04589777,0.0060058925,-0.081367664,-0.08280692,-0.0050949156,-0.07305232,0.032193042,0.06666958,0.05666114,-0.0056672655,-0.0036592246,-0.0097884815,0.027481804,0.10105789,0.068397224,0.0892139,-0.029784841,-0.004131406,0.002382414,0.055245936,0.037846696,-3.191751e-08,0.048450477,0.037230242,0.000748877,-0.043946862,-0.037750956,0.04847537,0.005996248,0.07269563,0.01548085,-0.019593447,-0.029871408,0.0890948,-0.094615415,0.012610742,-0.012230474,-0.03421069,-0.05459973,-0.032768756,-0.024079818,-0.025972966,-0.109774314,-0.002315872,-0.07291269,0.03577712,-0.057571784,-0.116900876,0.04781189,-0.026008502,-0.01274203,0.03602919,0.03251298,0.04017137,-0.027643826,-0.10865155,0.045613673,-0.016340347,-0.037895482,0.030738981,-0.006133752,0.022902679,-0.024161797,-0.03297473,0.03815477,-0.0038190172,-0.057989508,-0.055356275,-0.04864607,-0.02753312,0.0058719115,0.11588454,0.026808228,-0.026381543,-0.09956957,-0.031776115,-0.046515122,-0.08966221,0.024886841,-0.047203038,0.0150077185,-0.10135789,0.030598477,-0.05830622,0.13676442,0.019265033 +3.2.1.62,"The enzyme, found in the intestinal mucosa, hydrolyses beta-D-glucosyl and beta-D-galactosyl residues from a very broad range of substrates using a retaining mechanism. Characterized substrates include glucosyl- and galactosyl-ceramides [3], O3-, O4'- and O7-glucosylated flavonoids [6], and the 2'-O-glucosylated dihydrochalcone phlorizin [1]. The enzyme includes two glycosyl hydrolase domains, both belonging to the GH1 family. While one domain is responsible for the activity described here, the other catalyses the reaction of EC 3.2.1.108, lactase [4,5]. cf. EC 3.2.1.45, glucosylceramidase and EC 3.2.1.46, galactosylceramidase.",384,0.99999994,-0.02782675,-0.13068701,-0.041654915,-0.0050875084,0.08316729,-0.032055117,-0.057467327,0.024389945,0.057222888,-0.032801718,0.015082763,-0.006818431,-0.07001551,0.012074336,-0.068724744,-0.008108369,-0.013011732,0.009678736,-0.035835322,-0.048141085,0.10862807,-0.023425167,0.016716868,0.05319642,0.028771536,-0.026671318,0.11865588,-0.023529433,-0.01658567,-0.09278111,0.055219445,-0.11863296,0.051749535,0.020797338,-0.028735943,0.020515598,0.028521052,-0.093033016,0.0007254869,-0.0064075,0.019669924,-0.03210374,0.02595065,-0.08386855,-0.0060509695,-0.03153174,-0.0009835982,0.022991426,0.06962008,0.029385883,-0.014083717,-0.08992206,-0.036633536,0.021368789,0.034871742,0.04423667,-0.029364679,-0.016266657,0.0019403099,0.05791312,0.04277354,0.045031622,0.02843086,0.036596496,-0.088135555,-0.0808796,0.044275157,-0.043772683,-0.016110646,-0.03695593,-0.08064194,-0.040250283,-0.0074240053,-0.018389402,0.06520837,0.037675068,0.018068442,-0.01793254,0.022039384,-0.0031726733,0.07504524,-0.041829962,0.045406155,0.07744559,-0.044272102,-0.03213709,0.014990409,0.03396118,0.07793117,-0.0038831756,0.009944802,-0.07934402,-0.03105185,0.013011995,0.042921707,0.05781297,0.025586657,-0.030129768,-0.014624527,-0.011751508,-0.07725171,0.028883874,0.037339997,-0.072292104,-0.0017650871,0.07099238,-0.009908224,0.1063237,0.060106385,-0.024128214,0.045151535,0.030835025,0.06578527,0.051876113,-0.030956091,0.074426524,0.041736364,-0.067775294,-0.014342654,-0.0021756638,0.0355351,0.013544795,0.066613965,0.04558875,-0.07253785,0.038169064,-0.052750435,2.440476e-33,0.041178666,0.036888476,0.051542062,-0.005107261,-0.0058146496,-0.01726788,-0.117956184,0.0068792664,-0.012749323,0.0017981889,-0.051178444,-0.019451171,0.021432217,0.05869827,0.028985923,-0.002047539,0.0770928,-0.027307175,0.07017681,0.002775041,-0.018105336,0.04786306,-0.018252756,0.025459018,0.10233695,0.08045955,-0.030330855,0.03120577,0.0757333,0.023520837,-0.047461167,-0.12878248,-0.03994064,0.099661835,-0.018536499,0.06690826,-0.0544692,-0.05096569,0.035001066,-0.00054906885,0.022915266,-0.04132057,-0.019726414,-0.04415107,-0.008798631,-0.0887384,-0.02722178,0.078107655,0.05296257,0.114474274,0.043990128,-0.03409273,0.062250692,0.019296778,-0.0377195,0.016369091,-0.061543472,-0.010681241,0.08242312,0.05812807,-0.012770389,0.063878424,-0.024603687,0.048943155,-0.017602038,0.025003036,-0.06784376,-0.031886075,-0.07203365,0.042127818,-0.1020321,-0.056007434,0.076599166,0.018109329,0.06314706,-0.10923963,0.0054503577,-0.0012663488,0.01969747,0.036029942,-0.026649741,0.018679801,-0.003334312,0.044258304,-0.0504028,0.05182605,-0.06852993,-0.032221705,0.0068197506,0.06356749,-0.07478201,-0.0054680808,-0.042217646,0.059393387,0.03475182,-4.6814136e-33,0.10575973,-0.113665715,0.04392277,-0.070415504,-0.043308586,0.033123624,0.02950098,-0.040268082,0.010039419,-0.09984891,-0.002226196,-0.01824042,-0.040234342,-0.097506404,0.038749363,-0.012496212,-0.0064985254,0.08427961,-0.040594444,-0.00034635948,0.063862905,0.071251,-0.00016228277,0.020368839,0.057799123,-0.009233314,0.030920334,0.027249804,-0.022021916,0.08861314,-0.062458813,0.02578612,-0.025580581,-0.044455897,0.0036549377,0.018722383,-0.105209164,-0.03353883,-0.019480059,0.0406636,-0.03728213,0.06849428,0.008542827,0.04472891,0.0628637,0.13452166,-0.033354577,0.016032057,0.0048849243,-0.07082468,-0.027819436,0.01133621,-0.032855358,0.060438316,0.054879367,0.07367088,0.0077077607,0.028146267,0.057714164,-0.049163733,0.006096763,-0.040155236,-0.01325422,-0.065477885,0.064217664,0.029087799,-0.071459,0.037448578,-0.018205179,0.012027888,0.07303402,-0.08299667,-0.024539681,0.051370908,0.017148957,0.0097331805,-0.15299462,-0.03391381,-0.026274262,0.017168975,0.054439344,0.03888725,0.030659603,-0.03549615,0.031881604,-0.050129037,-0.017395563,0.13347733,-0.0035159972,-0.009884172,-0.021645335,0.012761064,-0.05616069,0.037939332,0.08492371,-5.1888104e-08,0.026066469,-0.06994064,0.00421247,-0.05434444,-0.040462352,0.01050317,-0.040501736,0.027217187,-0.01809446,-0.04959953,-0.07058906,0.09776747,-0.012225563,0.0040802048,-0.07058929,0.055918295,-0.054191265,-0.01921143,-0.015102135,0.04150396,-0.050039504,-0.01343344,-0.10693353,0.015864812,-0.027026977,-0.09043501,0.022255484,0.06744878,-0.06996975,-0.0014070979,0.027747607,0.010604863,-0.034818545,-0.023340238,-0.090269074,-0.013761378,-0.029769424,-0.0038562713,0.030948484,-0.004206697,-0.008122004,-0.04395779,0.0585586,-0.008678461,-0.025773685,0.048972353,0.031317234,0.048072055,0.0036143556,-0.020968774,-0.024666337,-0.041210543,-0.0371292,-0.017541273,-0.0594469,-0.07487384,-0.017336473,-0.10377093,0.009835236,-0.097862214,0.019936379,0.004056571,0.1511921,-0.036890857 +3.2.1.63,"Highly specific for non-reducing terminal L-fucose residues linked to D-galactose residues by a 1,2-alpha-linkage. Not identical with EC 3.2.1.111 1,3-alpha-L-fucosidase.",384,1.0,0.050530855,-0.043272708,-0.03510114,-0.013408978,0.119983576,-0.040224075,-0.0069676293,0.02192212,0.08915145,0.03982583,0.064691335,0.012293834,-0.07675934,0.037304845,-0.064478405,-0.0281263,-0.0362644,0.035563316,-0.03009871,0.052368414,0.12514006,-0.037848618,0.017483242,0.0059949756,0.033039726,-0.12354765,-0.023260228,-0.043983024,-0.00975439,-0.11498103,-0.025631357,-0.043589827,0.012339138,-0.02766007,0.008202536,-0.052166987,0.015539982,-0.04399523,0.04864169,0.015981419,-0.025129095,-0.003838743,0.044173777,-0.06512102,-0.06497529,0.014367043,-0.07587894,0.051845074,-0.0279865,0.061268933,0.044286095,-0.02914917,-0.041268665,-0.023770314,0.034674596,0.06587595,0.009198362,-0.0049221897,-0.036482826,0.104369685,0.069484666,0.11849839,-0.05583733,-0.010861139,-0.07090435,-0.08499788,0.069778144,-0.05674717,-0.026322505,0.015550407,-0.060052942,-0.08104549,0.03423036,-0.034602698,0.11580296,0.17711261,0.038906094,0.004600519,-0.039342657,-0.017926294,0.066854484,0.0029408082,0.029834418,0.040368576,-0.024139365,-0.046786398,-0.07171431,-0.028819246,0.01350325,-0.0016510085,0.04701975,-0.041746493,-0.0040647266,0.005111083,0.029643571,0.050752535,0.03383751,0.06745077,0.005744535,-0.030495515,-0.04505953,0.045715984,0.038764823,-0.07717462,-0.034815446,0.055575047,-0.020373764,0.049878016,0.07777624,-0.109031856,0.018758995,0.0011194713,0.086809784,-0.025443241,-0.07425132,0.0062570097,0.045528278,-0.08850538,0.025475815,-0.008361868,0.08539034,0.0041758884,0.058587313,0.053181827,-0.035598613,0.02406126,-0.015810926,-1.8538968e-33,0.07783443,0.12927668,0.028607467,-0.032264195,0.0072414484,-0.06486939,-0.04537652,-0.12208654,-0.04917952,0.08802287,-0.11390914,0.012933832,-0.02828637,0.012137402,-0.058564767,-0.007464216,0.051058456,-0.025039606,-0.006308952,-0.022883054,-0.011972199,0.003778561,-0.022922147,-0.05559058,0.12770492,0.06739663,-0.043097112,0.060786042,0.06998507,0.012779557,-0.012044541,-0.019178929,-0.045443676,0.051782377,0.02279583,0.018544875,-0.07101713,-0.050962597,-0.031474795,-0.048679262,0.09372473,0.059019614,0.012700837,-0.0023861995,0.0033082594,-0.046135094,-0.019194094,0.05810178,0.017200243,0.064657256,0.040816806,-0.024143847,0.036840525,0.01357654,0.016162597,-0.037368655,-0.0435077,0.007203584,0.018881606,0.08170788,-0.015533622,0.06751069,-0.08304912,0.043694686,0.031910382,0.009003701,-0.027000537,-0.023840612,-0.029446624,-0.027883094,-0.06844066,-0.046444375,0.103509076,-0.067711316,0.06977967,-0.06853471,-0.07193568,0.01886208,0.004776106,-0.032402623,0.04839948,-0.0021621813,-0.045567438,-0.02366117,-0.02723253,-0.025064383,-0.012475898,0.0099215675,-0.005994222,0.0047067245,-0.027961781,-0.02599011,0.026163192,0.081014246,0.0083643,-1.1379579e-35,-0.017736698,-0.04462032,0.055568784,-0.04025233,-0.057849165,0.032545213,0.046257515,-0.043833386,0.024965934,-0.09312841,0.045008868,-0.043914206,-0.044916775,-0.06749893,0.0026621146,0.013314338,-0.007785102,0.009411979,-0.034876123,0.038126785,0.022837335,0.020600209,0.03402997,0.050902013,0.066758,-0.034625508,0.08614954,-0.0019314089,-0.0056506847,0.015194056,0.037442416,0.06588268,0.03218724,-0.10554331,-0.022857016,-0.053488635,-0.06045642,-0.012478923,0.0685707,-0.008495659,0.02073031,0.028237652,0.04439359,0.018469641,0.068540104,0.08307634,-0.10624959,-0.044993404,0.061229266,0.007526337,-0.05169509,-0.052881517,-0.020119702,0.0038126984,0.013111189,0.039355233,0.020154817,0.042851605,0.012797225,0.012329789,-0.049328934,0.015953856,-0.0014046793,-0.046088524,0.09185353,-0.008031723,-0.031179577,0.04411996,0.06739399,0.006872165,0.029931182,-0.007002924,0.0074987,0.013712839,0.027241826,-0.070987046,-0.1295991,-0.03340084,-0.0016342092,0.043846555,0.0112821,0.027976017,0.014534272,-0.0035310036,0.021072278,-0.08423175,-0.040408805,0.11089752,-0.036989816,-0.0047996305,-0.04941207,-0.006903174,0.020939846,0.045007963,0.07277778,-2.928896e-08,0.11612758,0.015216009,-0.056358434,-0.055301573,-0.027440924,0.013064248,-0.07460127,0.045930747,-0.030487655,0.03198382,-0.027868839,0.14825419,-0.009760468,-0.0034467736,0.024956519,-0.0019183409,-0.004766567,0.009400706,-0.0074338866,0.038405787,-0.019932648,0.051682718,-0.07211112,-0.04971881,0.030584631,-0.048146613,0.0050485604,0.031355772,-0.055858355,0.022593757,0.036240354,0.018080324,-0.062470198,-0.029650688,-0.08210851,0.03846564,-0.047048014,-0.039069887,-0.02644375,0.047258403,0.062174693,-0.018022317,-0.013666285,-0.006406524,-0.079851665,-0.031292845,0.009041077,0.088392824,-0.045925528,0.05925703,-0.02304644,-0.0486396,-0.111819945,-0.042388324,-0.054040324,-0.06865158,0.063918225,0.049680103,0.05303957,-0.09495604,0.02149311,-0.040900774,0.10277754,-0.022508716 +3.2.1.66,Quercitrin is quercetin 3-L-rhamnoside.,384,1.0,-0.061392456,-0.067343995,-0.11590825,0.04556874,0.013949222,0.01819996,0.052277472,0.06313525,0.093050726,-0.08855377,0.00056205754,0.0099551175,-0.06180712,0.011033633,-0.07461853,-0.025998129,0.0064509185,0.050944813,-0.02025786,-0.03687767,-0.023750458,0.05746808,0.051029474,0.064036466,0.025857348,0.021683246,-0.021525983,-0.0018955527,-0.003149053,-0.02430569,0.061591387,0.045558557,-0.04428983,-0.0020603668,-0.066502474,0.011499703,-0.06421459,-0.03292669,0.021665804,0.019640082,-0.02295272,-0.060143135,-0.040389135,-0.0058880467,0.02212232,-0.032773126,-0.18357196,0.109807305,0.03700432,0.07047631,-0.040927596,-0.02590799,-0.0400646,0.045032065,0.024900196,-0.045404166,-0.10882282,0.012957012,0.025516536,0.049518973,0.034658752,0.07018728,-0.024966657,0.06354787,-0.041056473,0.017516896,0.030070204,-0.04357631,0.0634814,0.036773987,-0.02866659,-0.027048975,0.042395923,-0.040436454,0.027607193,0.11245554,0.015309604,-0.045500603,-0.07392147,-0.01589134,0.03416211,0.036704194,-0.04599303,0.14562467,0.035712186,-0.055297825,0.014942497,0.011178087,-0.0080897575,0.034861278,0.06274771,0.09126495,-0.03369445,-0.045016583,-0.057073254,0.026590327,-0.045809675,-0.04398867,-0.03617959,0.0052062264,-0.03983596,-0.04844217,0.01014148,-0.006089381,-0.069723204,0.021987915,0.036108498,-0.06117209,0.090718575,-0.062171344,-0.043560997,-0.03853538,-0.070970856,-0.03234432,-0.025145505,0.013897087,0.027841842,-0.0042962227,-0.019643629,0.0004226852,0.036320873,0.051634673,-0.027524684,-0.057777077,-0.018355763,-0.037309434,0.06169528,1.895163e-33,0.04487879,0.037580475,0.021410905,0.032829203,0.03300359,0.010618101,-0.0171586,0.019673204,-0.016882487,0.01689637,-0.052053384,-0.07340233,-0.0782124,0.06352046,0.007007889,0.026126247,-0.009697732,-0.018953955,0.0455563,-0.011109009,0.010978412,0.08820935,-0.051285602,0.035786707,-0.01024763,0.058131862,-0.010703514,0.07380142,0.055741735,0.0056323204,0.042711932,-0.045436483,-0.019234246,0.0048293318,-0.06306096,0.06765045,-0.0051233005,-0.05213185,0.012342395,0.05344431,-0.010609681,-0.005356762,0.00411994,-0.034735233,-0.047088373,-0.061153457,-0.04729459,-0.023549456,0.008776174,-0.013005429,0.008575839,-0.017508082,0.09150901,-0.0014621544,0.040877882,-0.011989417,-0.064225145,0.12173642,0.07986683,0.01408382,-0.0066475184,-0.002071671,0.016489992,0.024591599,-0.0014107818,0.028389372,-0.0509053,-0.0437696,0.02399661,-0.021718651,-0.0060495688,0.015161635,0.10207041,0.043160647,0.1338146,0.006064815,-0.055712156,0.0344607,-0.016611302,0.055609528,-0.11478417,-0.03196126,-0.0034386958,0.08586295,-0.04044298,-0.01997909,0.0660271,0.0103246095,0.037401374,0.04695085,-0.028490378,-0.108154945,-0.0059047733,-0.0032380598,0.0071085365,-1.5580572e-33,-0.010620854,-0.046277188,0.06470002,0.047464285,-0.032617453,0.029338336,0.013651166,0.011266748,-0.014536758,-0.05535045,0.089316055,0.010718697,0.008687281,-0.031162597,0.003015962,0.060721967,0.059165176,-0.018248104,0.007064432,0.036162335,-0.05229882,0.015102136,0.00016215601,0.0037448015,0.06749768,0.02191234,0.12403584,-0.058514148,-0.019012889,0.047275957,-0.08166375,-0.028241072,-0.05807119,-0.04751743,-0.047081213,0.10140568,0.04389455,-0.03730677,-0.12869187,-0.053723883,-0.0026191238,-0.019113809,-0.010379734,0.13562502,0.029417517,-0.007880462,-0.022952333,0.009074763,0.028300844,0.06841281,0.0496188,0.08286146,-0.0047594258,0.048415452,0.08891378,-0.0072382176,-0.0009250654,-0.054860897,0.023428446,-0.013874534,-0.04952593,-0.022028953,-0.0837051,-0.023821112,0.10830196,0.06894346,-0.03307215,0.10563266,0.08860915,-0.0771557,0.11529068,-0.053547602,0.073428564,0.015475454,-0.060641173,-0.06531883,0.008334893,0.0020479427,0.034168933,0.00162862,0.05375848,-0.11186657,-0.037470896,-0.03843568,-0.0077583925,-0.01815779,0.044482782,0.062600195,-0.029162366,-0.0014753025,-0.015771603,-0.004731001,-0.091930486,0.03207648,0.0701859,-1.9547294e-08,0.0783226,-0.049048435,0.026717676,-0.04072897,0.06540253,-0.0029893364,0.0058914544,0.02760951,-0.09201776,0.0464051,0.037384484,0.107462406,0.012299814,-0.024469098,0.017296333,-0.043427367,0.02160073,0.06916823,-0.025602922,-0.06842244,-0.08697733,0.04230303,-0.032566924,-0.16840991,0.0015070696,-0.012144989,0.040682994,-0.017918171,0.020260634,-0.050945193,0.044020224,0.00095755904,0.007293127,-0.0104728835,-0.02355599,-0.0045409477,-0.02589636,0.014451082,0.029752085,-0.031230737,-0.07207832,0.021423291,-0.023586182,0.01147636,-0.106776856,-0.09355336,0.019823473,0.056611057,-0.023212502,-0.038841482,-0.044461586,-0.030795326,0.01970033,-0.07572047,-0.014751868,-0.036561288,0.0946701,-0.024879344,-0.079477884,-0.022114694,-0.06552315,-0.030433401,0.085866906,0.047899634 +3.2.1.67,"The enzyme hydrolyses the first glycosidic bond from the non-reducing end of the substrate. It is specific for saturated oligomers of D-homogalacturonan, and is unable to degrade unsaturated substrates or methyl-esterified substrates.",384,1.0,-0.047687665,-0.049665906,-0.047303542,-0.005067608,-0.02376386,-0.028873548,-0.05587893,0.006491455,0.015242193,-0.022301244,0.08175028,0.09425056,-0.106517345,0.054066397,-0.075406216,0.024643578,0.016452286,0.023792986,-0.07468878,0.00664876,0.13949125,0.03797304,-0.069504336,0.0065545347,0.06523457,-0.0028130494,0.024699938,-0.009868053,0.041861404,-0.047699444,-0.025196088,-0.03084032,0.029136432,0.011074554,0.062878706,0.08206485,-0.049739845,-0.07856393,0.004746217,-0.02977267,0.07505656,-0.003040747,-0.013036821,-0.024028778,-0.06930544,-0.08952749,-0.031347815,-0.0053723077,-0.03276945,-0.0056274673,-0.014050575,-0.08192941,-0.018642712,-0.01713918,0.006555083,0.074695796,-0.08132388,0.010316824,-0.0505195,0.024070922,0.060750194,0.108909465,-0.0541323,0.013385199,-0.026328877,-0.0773116,0.08418337,-0.035302997,-0.017386215,0.045006502,-0.02905649,-0.03736789,-0.026689611,-0.073903866,0.08211452,-0.03432102,-0.05382491,-0.04885564,0.080186956,-0.066868216,0.060077902,-0.04130414,0.0505074,0.07370278,-0.009667394,0.006107398,0.013830222,0.004142985,0.04937753,-0.018585823,0.0017299893,0.00094934035,-0.04544267,-0.015606748,-0.07100575,-0.020138748,0.052749004,0.019085823,-0.007718282,0.040174488,0.0048646075,0.01864875,-0.030888684,-0.06925971,-0.054928403,0.02583741,0.026830498,0.09724896,0.03201859,0.0065598427,-0.0044553685,0.035425153,0.0690391,0.03565213,-0.08707306,0.027625294,0.017704744,0.00060540746,-0.007646623,-0.03503508,-0.0047033005,-0.02271618,0.044484157,0.06451215,-0.05404534,0.06286268,-0.04439187,-7.673977e-35,0.100061044,-0.048363116,0.00478225,-0.054664455,-0.040268943,-0.052100748,-0.054231618,-0.012873529,-0.021532102,-0.009255985,-0.04948019,-0.016563889,-0.0575345,0.15731631,0.004955265,-0.012448152,0.018993078,-0.0017789775,0.08000773,0.041983493,0.02021806,0.12545829,-0.063965335,-0.027493125,0.005973754,0.015410885,-0.06963514,0.0843275,0.054827884,0.033285465,0.024305584,-0.09738919,-0.09009788,0.029872013,0.07308402,0.114561275,-0.0059914044,-0.051083393,-0.009553677,0.016719755,-0.015352343,-0.006683152,-0.011201863,-0.060659125,0.030145105,-0.0093643665,0.008805442,0.072500445,-0.010173221,0.044374272,0.026599953,-0.022944152,0.052303698,-0.005256806,-0.10567458,0.05486897,0.020759597,-0.016706135,0.0058696438,0.048552692,-0.09032618,0.013532716,-0.040516526,0.024482114,0.009307551,0.047670525,-0.011783066,-0.033690028,-0.026389388,-0.0054407297,-0.106482215,-0.021799708,0.010933661,0.023044655,0.0007775424,-0.09931699,0.013598242,0.008139431,0.0492435,-0.0125473,-0.010026786,0.008324491,-0.059849575,-0.047721874,-0.10376513,0.024992295,-0.023611404,-0.03743516,0.036420584,0.083226055,-0.025311725,-0.04258715,-0.010692448,0.03825992,0.05872407,-2.6654643e-33,0.043106686,-0.089118086,0.044122208,0.01867036,-0.0794964,0.042308193,0.059266496,0.04834676,0.014711197,-0.08079912,0.029091988,0.039865702,-0.01659751,-0.020196356,-0.013471659,0.0473998,-0.082075946,0.06988963,0.010241176,0.016017847,-0.018225497,0.08715282,-0.026054604,0.046543267,0.113628656,-0.010632912,-0.036154404,0.0920222,-0.004755512,0.030021109,0.042434312,-0.018369203,-0.029929774,-0.091512136,-0.04965028,0.11277022,-0.10252225,-0.0050702156,-0.017144993,0.010482623,0.0083961515,0.022025162,0.053294323,0.07522736,0.07230589,0.09441137,-0.088365406,-0.03593944,0.023704363,-0.045579854,-0.0073420163,0.032661144,0.009837717,0.039153274,0.053082936,0.04115567,0.05445035,0.0048966417,-0.06744727,-0.027404042,-0.034514014,-0.045488544,-0.010073345,0.0077137435,0.07137547,0.0025393213,-0.006414641,0.044448286,0.05176903,-0.032775376,0.0588393,-0.015845554,0.00576816,0.006112732,0.0031865195,-0.032044765,-0.13470599,-0.016596597,-0.0057853563,-0.01700137,0.028069826,0.023836175,-0.026491899,-0.051089536,-0.010123896,-0.0907856,0.04959997,0.09055929,0.008122123,0.08656051,0.0054269945,-0.036263563,-0.05176657,0.06826391,0.017616704,-3.546004e-08,0.027656274,-0.052767448,0.033310868,-0.10241461,-0.05099316,0.02812696,0.065098524,0.013954034,0.053270683,-0.0029313946,-0.05052338,0.07721078,-0.064198844,-0.033217493,-0.022694547,0.041008268,-0.05566811,-0.0019376043,-0.030756997,0.027606234,-0.09850109,-0.03454066,-0.11483647,0.024133835,-0.013371467,-0.05974169,0.0829567,0.09253861,-0.015856506,0.038143493,-0.0038862084,0.07872093,-0.011819156,-0.0042207497,-0.02897081,0.048581492,-0.06020179,-0.017060593,-0.020858692,0.027693553,-0.020416854,-0.012198621,-0.019812,-0.013524033,0.037793577,0.021589726,0.044169594,0.07610028,-0.028404286,0.037672866,-0.01651027,-0.02618061,-0.07539499,-0.08176591,-0.12328643,-0.031830493,0.013907978,0.023015298,-0.08151337,-0.075671434,0.003035025,0.035276722,0.15981467,-0.043933548 +3.2.1.68,"Also readily hydrolyses amylopectin. Differs from EC 3.2.1.41 (pullulanase) and EC 3.2.1.142 (limit dextrinase) by its inability to hydrolyse pullulan, and by limited action on alpha-limit dextrins. Maltose is the smallest sugar it can release from an alpha-(1->6)-linkage.",384,1.0,-0.019208064,-0.13353841,-0.0076512713,-0.002211256,-0.023508752,0.0032799982,0.024699165,0.033346374,0.025180466,-0.06863056,0.016247468,-0.006442916,-0.10818498,0.018946743,-0.051772147,-0.014728377,-0.022408362,-0.00936897,-0.032578204,0.029955685,0.11506377,0.0066303588,0.00078596943,0.06009038,0.041956306,0.012091775,-0.0007677586,0.039268706,0.013312776,-0.09079819,-0.031605158,-0.0585054,0.002632115,0.009275576,-0.009277251,0.091698624,-0.02679814,-0.05616725,-0.015429422,0.00760427,0.060763016,-0.048753202,0.04931697,0.026121529,-0.10347254,-0.09053783,-0.08076861,-0.046431903,-0.013172935,0.0059733307,-0.046928275,-0.0874326,-0.025933715,0.051215135,0.050001923,0.0066321767,-0.05359553,0.020871922,-0.012496081,0.053272292,-0.034415677,0.10750878,-0.0058239885,0.00930752,-0.014871472,-0.044887662,0.027763741,-0.10116749,-0.05665759,-0.01795797,-0.028676739,-0.051591456,0.004723767,0.06292197,0.059081122,-0.034601286,-0.015511351,-0.039150365,0.005116979,-0.02956603,-0.019963242,-0.0027562152,0.023413133,0.11056536,-0.0831467,-0.1082153,0.057186488,0.022558738,0.02768061,0.048272714,0.06280465,0.017593086,0.03184819,-0.015483566,0.09806467,-0.0017630025,-0.014010015,-0.11029732,0.012419972,-0.01007578,-0.04429594,0.12553848,0.062741965,-0.024795888,0.032044154,0.045817617,0.01808027,0.003980268,0.05164726,0.020056605,0.00059005414,-0.027727911,0.0321214,0.020879345,-0.078036115,-0.0079507325,-0.033303317,-0.059932724,0.041256167,0.0070169875,-0.01713215,-0.0030380627,0.10125427,0.012350241,-0.021171989,0.09564451,-0.113454945,-6.9457583e-34,0.06968068,-0.07583811,-0.0038365321,-0.03549503,-0.036284998,0.032718275,-0.08047371,0.0140686855,0.026446754,-0.002951415,-0.13422331,-0.00012842297,-0.017718647,0.077458814,0.061430566,-0.028988875,0.010121553,-0.04930891,0.03636646,0.07732661,-0.00998043,0.028044606,-0.03781371,-0.022014717,-0.0047428776,0.0013934097,-0.06304181,0.054388087,0.059083,-0.015950516,0.050743833,-0.073962,-0.034686457,0.046662766,0.016637236,0.06123719,0.01554821,-0.01743989,0.066619635,0.015368927,0.07149369,0.024964226,0.082364246,-0.055271864,0.057466973,0.050350446,-0.016271984,-0.02292392,-0.00039802448,0.038443733,0.07476982,-0.028438758,-0.034935784,-0.005646831,-0.01257983,0.018147534,-0.014140685,0.08279643,0.021057956,0.09384044,-0.058362316,0.10964693,0.08775091,-0.069243975,0.021641292,0.06487586,-0.042643357,-0.060079627,-0.09300519,-0.04114436,-0.10675941,-0.027657062,0.09460108,-0.06955121,0.01504653,-0.058231495,-5.9603197e-05,-0.010886753,0.04773256,-0.06184268,-0.038016964,-0.05171502,0.06641584,0.038526785,-0.08684083,0.051404655,-0.044593986,0.026280776,-0.034880634,0.07988259,-0.008963757,0.019159693,-0.016967645,-0.020475307,-0.002172173,-1.5417297e-33,0.0820076,-0.106155045,0.06141013,-0.014602604,-0.007740777,0.05295295,0.03755209,0.041496754,0.008593512,-0.03671585,0.060586777,0.058106147,0.022378055,-0.115775704,0.03806878,0.04039093,-0.09670877,0.03449268,-0.022548117,0.014945675,-0.006738104,0.13595407,0.006642614,0.045197945,0.066228524,-0.043646403,0.042741124,0.05701395,-0.0139647955,-0.051786274,-0.010474358,-0.04312235,-0.0524187,-0.09661205,-0.09034283,0.012519555,-0.06510531,-0.042578336,-0.04842388,0.0024278818,0.01639887,0.039076366,0.039958436,0.03856356,0.027427813,0.1256031,-0.009714789,-0.061499666,0.0328175,0.03623453,-0.031799547,-0.05852934,0.023387209,0.06621303,-0.0064084805,0.02300559,0.007077826,0.0069109234,-0.05369057,-0.001597214,-0.035923578,0.0024108991,0.026102189,-0.027037129,0.028020784,0.0050105024,-0.07130146,0.0018831051,0.027831037,0.01153886,0.048510626,-0.06115104,0.07133676,-0.0038865546,0.020069217,-0.013803712,-0.11304848,-0.06747834,0.01733582,-0.09479244,0.07225656,0.11823755,-0.039299436,-0.03550931,0.017941605,-0.040119573,0.057106767,0.0179125,-0.032577217,0.018844513,-0.01097385,-0.04877432,-0.0064702886,0.020813942,0.011562477,-3.6793686e-08,0.07088466,-0.061786875,0.023295274,-0.013202945,0.047221456,0.036209896,-0.02417061,0.061099675,-0.009599543,-0.011452966,-0.015362305,0.09434886,-0.05253596,0.08974891,-0.011646788,-0.025469469,-0.023595754,0.0511026,-0.012554569,-0.031642098,-0.13628878,-0.0009336095,-0.06173016,0.02252475,0.013477397,-0.056195322,0.04917946,0.0878859,-0.030667705,-0.019199464,0.057563454,0.06608147,0.013798067,-0.030516513,-0.024564154,0.027184967,-0.05258687,-0.004632913,-0.013400654,0.0052721594,0.04798098,-0.08434487,-0.015501255,-0.021948889,-0.059062574,-0.0064349384,0.026804931,0.023843145,0.054462668,0.033326235,0.06359771,0.017900838,-0.037960533,-0.03971388,0.008892745,-0.014247857,-0.048613705,-0.052895226,-0.014200713,0.0003868301,0.0058189593,-0.021346355,0.1663279,0.022284305 +3.2.1.70,"Hydrolysis is accompanied by inversion at C-1, so that new reducing ends are released in the beta-configuration. Dextrans and isomaltosaccharides are hydrolysed, as is isomaltose, but very slowly. The enzyme from some sources also possesses the activity of EC 3.2.1.59 (glucan endo-1,3-alpha-glucosidase).",384,1.0,0.025881993,-0.06661304,0.004075923,0.026017064,0.031041112,-0.017704822,-0.07956024,0.013135508,0.034236025,8.488545e-05,0.061291117,0.044828318,-0.09617772,0.011546069,-0.079426706,0.0074408515,-0.013780105,-0.011172356,-0.05864348,-0.027178163,0.09885832,-0.050363213,-0.046623833,0.041435696,0.05804795,0.011264042,0.028035367,-0.065594435,0.0019415112,-0.11365524,0.010015237,-0.08414377,0.09426228,-0.026782949,0.03767892,0.06801504,-0.029678931,-0.061954964,0.018554531,0.010193798,0.027917257,-0.050052747,0.017648114,-0.010520864,-0.022983626,-0.063659765,-0.0039849724,-0.043298855,0.0146840345,0.05379041,0.05194296,-0.10179567,-0.088027425,0.01357224,0.020420954,-0.013123487,-0.103001595,0.014010321,0.0016156052,0.08075894,0.050187185,0.08459246,-0.080863684,0.0031033936,-0.012290503,-0.08784687,0.10417813,-0.10040232,-0.02874628,-0.034805235,-0.053493205,-0.060384374,0.027987374,-0.030635526,-0.023070626,-0.021495366,-0.008469242,-0.04089749,0.038722206,-0.014664084,0.072937615,-0.07083976,0.007606821,0.09086403,-0.033886448,-0.0075621717,-0.036716286,-0.0073997984,0.014781873,0.03972123,-0.00092239265,-0.02212381,-0.009323059,0.009598387,0.038839683,0.019562075,0.033146854,0.040099632,0.06240028,-0.029441219,-0.031870946,0.06715175,-0.01329895,-0.07493745,-0.014711382,0.04626461,0.02142109,0.12541509,0.030442677,0.030865112,-0.038210418,0.0028447702,0.0028084728,-0.008462235,-0.041661613,0.06247926,0.05897931,-0.05181789,-0.041140657,-0.010099273,0.025707152,0.0028976079,0.09817849,0.041422714,-0.05539611,0.091355674,-0.011741898,8.969675e-34,0.019311778,-0.045822486,-0.00079862814,-0.075905725,-0.0720946,0.011338925,-0.1029125,0.0057288194,-0.03187263,-0.0034495564,-0.09525823,0.044163086,0.00359257,0.10539737,-0.016126376,-0.035011563,0.06933845,0.0037546658,0.017324833,0.019773934,0.007829088,0.049148507,-0.053925045,-0.018324904,0.025647866,0.03362682,-0.04868607,-0.0032656305,0.040923294,-0.023804266,-0.004254527,-0.037581198,-0.05286573,0.09470959,0.027452843,0.0932597,0.011455788,0.005210989,0.031941567,0.029717844,-0.011347297,0.013965951,-0.024494082,-0.0950772,0.065837376,-0.0552366,0.00034461642,0.022590695,0.05057645,0.02299984,0.04654493,0.015826797,0.011235666,0.016342085,0.02249091,0.020094397,0.004092375,0.021647513,0.014124821,0.051586494,-0.041370664,0.12369145,-0.029269174,-0.04815988,-0.021073058,0.02847613,-0.06371023,-0.004614278,-0.026617838,-0.0016518214,-0.1323833,0.022307899,0.06369291,0.034456927,0.04297961,-0.013337153,-0.06720963,0.043479472,0.018266585,-0.02369835,-0.008007293,0.040479947,0.04918149,0.032419134,-0.021289634,0.07313957,-0.0058902446,-0.0139944265,0.013315164,0.06995415,-0.029041901,-0.03625621,-0.08949585,0.075213,0.037853833,-3.269142e-33,0.09069058,-0.101135164,-0.053941533,-0.059098378,-0.023672337,0.035309397,0.02088043,-0.010941911,0.02203337,-0.023949461,0.026859114,-0.004124073,-0.03735786,-0.0552096,-0.0029461267,-0.056759372,-0.0472779,0.03223451,-0.029656634,-0.027081175,-0.036491536,0.118313335,0.07098073,-0.014295741,0.096463785,-0.041369263,0.047191802,0.052379526,0.048912182,0.056614216,-0.062206443,-0.0364163,0.040551156,-0.057974923,-0.0034032501,0.09901987,-0.13929693,0.03432331,0.050588973,0.0033238463,-0.011421645,0.01785902,0.008213921,0.056668233,0.06349458,0.118414365,-0.057206795,-0.0017988787,-0.039549816,-0.04390876,0.009749288,-0.03805203,0.0006871363,0.09810857,0.08131578,0.014252617,-0.0125514325,0.01052075,-0.011765708,-0.05025467,-0.037672374,-0.012375597,0.06514604,-0.10776873,0.053696238,0.02219359,-0.051678073,0.055045433,-0.03195119,0.04040898,0.010024664,-0.08363595,-0.005543549,0.019472927,0.053803906,-0.05636344,-0.1275604,-0.08769251,-0.028700497,-0.08617097,0.013758625,0.07899343,0.008654466,-0.086216226,0.043992504,-0.07383893,-0.0200042,0.086884156,0.011573831,0.07419517,-0.012055686,0.0127793,-0.08662596,0.054019462,0.026588585,-3.8756923e-08,-0.016242398,0.01754941,0.07782804,-0.012501677,0.020322314,0.06493024,0.038924783,0.07821992,0.0134859,-0.04684305,-0.00600558,0.12092361,0.0020054632,-0.014212797,-0.017724507,-0.011861217,0.014680188,0.016014777,0.016858889,-0.013918183,-0.14614671,-0.032714847,-0.06709717,-0.028496657,-0.011397071,-0.08451944,0.038852412,0.03898111,-0.083225936,-0.006816506,0.023928806,0.06594382,0.03371391,-0.055092916,-0.02331905,0.08444094,-0.012445975,0.017092181,-0.011771933,0.024262536,-0.0053832275,-0.05654095,-0.01818553,0.0050021177,0.004600477,-0.010879716,0.038639396,0.008637403,-0.0028643645,0.02295729,0.040425647,-0.10242914,-0.09585509,-0.06148952,-0.018073393,-0.030765781,-0.019323368,-0.0482393,-0.019164218,-0.054079894,-0.031960722,-0.036399852,0.16616496,0.0029125116 +3.2.1.73,"Acts on lichenin and cereal beta-D-glucans, but not on beta-D-glucans containing only 1,3- or 1,4-bonds.",384,0.99999994,-0.02290635,-0.14162889,-0.006000735,0.0016635054,0.027813382,0.048878744,-0.022377402,-0.05522109,0.083600834,0.06286982,0.037219327,0.07419646,-0.07888444,0.04681386,-0.03859172,0.04545731,-0.041322004,0.06454947,-0.05414427,0.044481423,0.054729305,-0.02115403,0.011853896,-0.027458292,0.04575204,6.222365e-05,0.02322701,-0.06452219,0.0053336415,-0.08297802,-0.077014744,-0.04943294,0.016419066,0.03251573,0.043479323,0.026471682,-0.03529854,-0.054506205,0.0065391343,0.029439168,0.07249047,-0.054710645,0.032495826,0.0024586474,-0.040434416,-0.04508456,-0.0688165,0.023806948,0.0358121,0.015394817,0.04690739,-0.059526462,-0.041991103,0.051096994,-0.04426293,0.004599156,-0.10648679,0.03341693,0.03481764,0.078096926,0.021924037,0.046348445,-0.00565843,0.019135257,-0.035421595,0.02224604,-0.02939504,-0.008195844,-0.07899772,0.012536298,0.027891433,0.0007361429,-0.010156198,0.024375942,0.077128574,0.0034196805,-0.020009682,-0.031740133,-0.050594635,-0.045561578,0.02485117,0.030213384,0.124090634,0.03596573,-0.06740941,-0.046861973,-0.06675693,0.023263833,0.014194619,-0.018371787,0.0631479,-0.034209352,-0.014533617,0.049042266,0.015985807,0.03504092,0.09960572,-0.03012028,0.00760387,-0.009589465,-0.03012622,0.0071259663,-0.021309234,-0.05024506,-0.012020843,0.06134174,-0.053284135,0.014066619,-0.01887709,-0.027725112,0.041190963,0.00765087,0.07315569,0.008889231,-0.07712151,-0.04985781,0.07445738,-0.05702687,-0.0023112234,0.00841782,-0.00095394655,0.01797232,0.020264791,0.07009816,-0.06736314,0.023340978,-0.016675469,-2.026409e-33,0.03913162,-0.06206859,0.01814183,-0.007896141,-0.014027738,-0.027539656,-0.043589357,-0.057799377,-0.016119115,0.018167285,-0.088682294,-0.025430717,0.0076799826,0.063551426,0.0053667454,0.17087124,0.009637297,-0.08857326,0.075302914,0.00051289133,-0.02967116,0.07502129,-0.08479203,-0.019743066,0.0002210482,0.052412614,0.028437488,0.03499225,0.03588007,-0.053770706,0.022573425,-0.01054009,0.0026195974,0.09159243,0.035906825,0.13888282,-0.005267547,-0.0032457786,-0.061703023,-0.04932648,0.014655371,0.0041541983,-0.08445902,-0.06609742,0.056171328,-0.0008979255,0.033498976,-0.0024021498,-0.059981927,0.068965584,0.15139374,0.05030244,-0.017080152,0.06384783,-0.06887863,0.025513547,-0.034656737,-0.014390276,-0.022050634,0.09718564,0.0058502443,-0.0011114491,-0.0036535254,-0.028768167,-0.0027882888,0.03402809,-0.10873891,-0.03512027,-0.07202245,0.04314038,-0.042229693,-0.026952261,0.03932957,-0.05781233,0.03332773,-0.04242019,0.0012762793,0.05210204,0.015684843,0.0532961,0.04362795,-0.08871657,0.045250908,0.01588223,-0.10786967,0.05655991,-0.040090162,-0.07982594,0.06800873,0.030461112,0.016420102,0.027289443,-0.055095814,0.03927717,-0.0041516717,-1.1929411e-33,0.020211989,-0.10036306,0.057857297,0.046213266,-0.04999858,0.06343718,-0.029934246,-0.062133756,0.009035623,0.019470176,0.091768414,0.016964175,-0.08863048,-0.022119537,-0.026512977,0.0409415,-0.0442374,0.0032191344,-0.03251222,0.026580127,-0.07751395,0.07368501,0.007161343,0.07728631,0.045415465,-0.03853854,0.06268342,0.0035175998,0.0074424595,0.016714402,0.032870546,0.001755781,-0.017798364,-0.014798704,-0.026522556,0.0045652455,-0.08320058,-0.02697839,0.0106537305,0.018047854,0.000536299,-0.05117295,0.03892562,0.021752758,0.072411045,0.046992958,-0.0011527105,0.009301194,-0.03352054,-0.03805055,-0.040820267,-0.007642779,-0.02131448,-0.004896223,0.11037225,0.07578208,0.044580493,-0.019558752,0.031787984,-0.029456722,-0.049552377,0.015296018,-0.0056823343,-0.11397697,0.110798284,-0.006689182,-0.05571861,0.035129886,0.040101074,0.046145767,0.071774155,-0.01297762,0.040739596,-0.022772513,-0.024692697,-0.053808037,-0.041025776,-0.0806742,-0.032013908,-0.026445635,-0.028885305,0.053241413,0.04006506,0.0015763063,0.0022809857,0.0388608,0.038879048,0.10392473,-0.008298685,0.069841854,-0.001589427,0.05260711,0.04847252,0.014381488,-0.005579139,-2.8843898e-08,0.04538429,0.066744626,-0.091006264,-0.08112757,-0.11237427,-0.005009959,0.05581899,0.05584472,-0.013425323,0.060261756,-0.067529716,0.08863132,-0.06866209,0.01676935,0.029086532,-0.0032212336,-0.04925623,-0.021631127,-0.02503403,-0.021732835,-0.12645532,0.037741926,-0.089795366,0.075427614,-0.10496696,-0.10488368,0.060952436,0.04386422,0.07167754,-0.015340837,0.04122505,0.03598867,-0.044517852,-0.10522881,0.00037686198,-0.00071880413,-0.019659026,-0.01711223,0.087056324,0.011354428,-0.028643353,-0.010340775,0.019066691,-0.015644068,-0.10822532,-0.05116417,-0.04626965,-0.034878757,0.014930882,0.09033457,0.03300688,-0.005571715,-0.10410626,-0.037516564,-0.069931455,0.011760262,0.027944349,-0.028893696,0.046303716,-0.101185486,-0.022112092,-0.09217236,0.044138726,0.030483646 +3.2.1.74,"Acts on 1,4-beta-D-glucans and related oligosaccharides. Cellobiose is hydrolysed, but very slowly.",384,0.99999994,-0.0010211811,-0.10221259,0.008894783,0.024437351,-0.09101229,0.01870774,-0.025557619,-0.021336205,0.10598974,0.056824185,0.005360669,-0.010475743,-0.042954974,0.070988424,-0.0954956,-0.032602463,0.030685252,0.022742676,-0.09922212,0.028000696,0.074070565,-0.012519874,-0.02681305,-0.053677015,0.08226277,-0.01320954,0.033338275,-0.037931465,-0.0040683877,-0.08637784,-0.008437957,-0.0251129,0.062321957,-0.0041964487,0.027019575,0.09307142,0.0067987945,-0.048777368,0.07001574,-0.03878958,0.07365714,-0.0057001906,0.07632391,0.031254865,-0.04130876,0.008802168,0.030599324,0.009815565,0.01630351,-0.003951044,-0.038531374,-0.11646938,-0.051479943,0.04372105,0.019727116,-0.0013739071,-0.08206721,0.03370376,0.13595042,0.06556862,0.013425386,0.012643031,-0.011331914,0.022993818,-0.03703862,-0.054320637,0.03616715,-0.045634106,-0.08423667,0.014632742,0.0017627997,0.044795033,0.015879562,-0.0026757084,0.047490682,-0.011785611,-0.055237047,-0.10096543,0.006271085,-0.013320313,0.04696503,0.046493426,0.041876685,0.0540484,-0.027352348,-0.031608954,0.0205796,0.019596646,-0.03642028,-0.019135067,0.03298264,0.002097571,-0.024638265,-0.013159544,-0.053220063,-0.028631043,0.054986738,0.0055556325,0.089480095,-0.042004127,-0.048777267,0.016262382,0.088667326,-0.02212502,-0.02964479,0.011883693,0.03917876,0.09505575,-0.0025861822,0.0130046485,-0.05213098,0.0016764101,-0.011809121,0.0014902237,-0.09954175,0.037350502,0.05900501,-0.06498369,-0.061859474,-0.002854099,-0.008166136,-0.05667636,0.090469986,0.0431056,-0.07632114,0.08549302,0.013633895,-1.0009825e-33,0.024673253,-0.07200871,0.03196608,-0.02306978,-0.006311357,-0.0832603,-0.04587055,-0.01141314,-0.006008402,-0.0062178397,-0.036628604,-0.004628414,0.01402446,0.1606708,-0.017791213,0.060203314,-0.012562535,-0.13505676,0.029175874,0.013392085,0.0143831745,0.054447956,-0.021663483,0.009780591,0.034798104,-0.042563967,-0.004945571,0.002563631,0.078270495,-0.023082795,0.04350658,-0.029520426,-0.113435276,-0.023628624,0.041193783,0.11517943,-0.02634953,-0.0021152576,0.027353218,-0.049057424,-0.023565339,0.011265603,-0.018983062,-0.07472757,0.079697005,0.0039872495,-0.046894204,0.0027621584,0.00060389854,0.095267564,0.14718533,0.036177166,-0.010569502,0.002009738,-0.05891325,0.06310551,0.027786983,-0.01610411,-0.03236232,0.05259394,0.022425137,0.053366173,-0.028773468,-0.009615844,0.0017182623,0.04443779,-0.08181284,-0.021180551,-0.0034873183,-0.046716828,-0.08017274,-0.03211076,0.038756173,-0.0331857,-0.035874087,-0.022441259,-0.025227398,-0.031438228,0.033276528,-0.017959004,0.03893353,-0.018450968,-0.00483868,0.00027270615,-0.07300991,0.026641047,-0.027762668,-0.028948667,-0.043414205,0.10466695,0.006048752,-0.022925407,-0.10357173,0.036415327,0.0076461295,-2.0529957e-33,0.10365324,-0.090933226,0.043886323,0.026707506,-0.03576546,0.042188354,-0.020308759,0.029946102,0.0044235825,-0.04058785,0.06075451,0.05020564,-0.014702979,0.019133152,-0.02327355,0.020840561,-0.0950266,0.05252329,-0.020474093,-0.010920683,-0.06092943,0.103592865,0.0898216,-0.0062098717,0.06505102,-0.0072029615,0.042905677,0.065559044,0.015095498,0.089203596,-0.016789759,-0.008962458,-0.044693727,-0.08787296,-0.058987197,0.049725454,-0.07171197,-0.056167472,0.022713505,-0.044830386,-0.005029842,0.026074795,0.03359982,0.013053805,0.044205844,0.12273563,0.0035105096,0.044391662,-0.04417565,-0.0012408952,0.014864254,0.013063528,-0.04431538,0.024149258,0.09963157,0.042967334,0.051668152,-0.058533233,-0.03140529,-0.11262059,-0.06823431,0.0021578134,0.07954365,-0.12589003,0.05844361,0.050341077,-0.055656876,0.014095127,0.045382753,0.042746507,0.070599206,-0.003758755,-0.063797414,-0.021482786,-0.034060314,-0.017015032,-0.13174784,-0.03556251,-0.050319996,0.0028969715,0.023821838,0.09617565,-0.0008170643,-0.038912706,0.06082043,-0.03036871,0.050401196,0.08126647,-7.663134e-05,0.10970967,-0.005577854,0.0036526027,0.034493953,0.013448459,0.03422518,-2.6794584e-08,0.010090509,0.040120024,0.0137858065,-0.06057393,-0.07187876,0.00072503416,0.016414182,0.043877188,0.0084599955,-0.0034790842,0.008804134,0.09977426,-0.025601886,0.043546177,-0.016542805,0.035941828,-0.04943393,-0.056164213,-0.024368972,-0.004966775,-0.11753577,0.00611413,-0.030162985,0.08588977,-0.09398465,-0.094616726,0.051504817,-0.0017972474,-0.038048394,-0.034306727,0.031023767,0.07425333,-0.051384002,-0.11513581,-0.06343237,0.01501835,-0.05589825,-0.036801998,0.020247245,0.0050292946,0.023788739,-0.01716754,-0.03908681,-0.012170465,-0.022785245,-0.008012725,-0.031289544,0.010719813,-0.026790693,0.059916336,0.0076636854,-0.027099166,-0.10648983,0.022550104,-0.09413116,0.015008411,-0.046639923,0.0043356577,0.008319049,-0.07046404,-0.027325561,-0.006039881,0.069719344,-0.009477674 +3.2.1.75,"Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.",384,1.0,-0.051169567,-0.16364287,-0.03955885,0.047025852,0.011534355,0.037784997,0.0023222915,0.048580345,0.08331546,-0.0050459024,0.04304386,0.088241935,-0.0851949,0.023745209,-0.05047151,0.024443889,-0.036321238,0.0010427195,-0.01351578,-0.0057367156,0.01670938,-0.01389088,0.018137781,-0.012639186,0.031896368,-0.030731171,0.051111713,-0.03146116,-5.8390324e-05,-0.09821658,0.031853467,-0.03352916,0.02533897,0.04186201,0.004926191,0.046010442,-0.038136475,-0.047634866,0.023884859,-0.016167818,0.03895686,-0.04528485,0.04808206,-0.03096928,-0.054831415,-0.032472383,-0.023810063,0.10183952,0.041274633,0.049951583,0.030202247,-0.10909458,-0.021856954,0.01857769,-0.01081152,-0.018147074,-0.1843091,-0.0078062587,0.080516994,0.02058452,0.007565775,0.059543807,-0.019666133,0.033746086,-0.09738526,-0.017994607,0.031808387,-0.022813864,-0.08439211,0.055568114,-0.00037427642,0.0003646369,-0.016049705,-0.055147868,0.04637934,0.04072122,-0.06115731,-0.07738175,-0.035712507,-0.04791637,0.043954678,0.05646853,0.12513243,0.07156826,0.033786166,0.0022060995,0.03990813,0.08815461,-0.040760346,0.013938349,0.0419475,-0.041811943,0.023108222,0.014067751,-0.026279286,0.06386827,-0.020159125,0.02714524,0.011410381,-0.02178007,-0.03897774,0.0141212,0.059403248,-0.011984929,-0.016144384,0.063119896,-0.0025242805,0.0368021,-0.00053985167,-0.052423093,-0.017490044,-0.02797576,0.04773797,-0.05519098,-0.056290053,0.0024529763,0.032285478,-0.030377796,-0.07520574,-0.023937298,0.048185892,0.011457947,0.03161902,0.043084085,-0.10118976,0.054190494,-0.024757095,-9.064111e-34,0.07656569,-0.061628975,-0.0005125161,0.011264499,0.022804527,-0.03791167,-0.031087724,-0.083362564,-0.016831763,0.019421149,-0.10752064,-0.025446681,0.039013762,0.088779315,0.029677538,0.07872135,0.05494897,-0.017246988,0.083999604,-0.028083697,0.02253541,0.056670886,-0.07263261,-0.0112756435,0.004965383,0.064199984,-0.02110482,0.08909273,-0.0057078176,-0.03481956,-0.015199939,-0.07449433,0.01717731,0.06539053,0.046514783,0.08323063,-0.05951192,-0.024614176,0.018474959,-0.07815822,0.008279879,0.008634117,-0.122594416,0.010810852,0.06403929,-0.015200422,-0.00851868,-0.008269529,-0.0036791363,0.10300201,0.0947843,-0.026590722,0.06440005,0.006554903,-0.007836133,0.0614487,0.0039679566,0.020918652,0.027523145,0.05120856,0.002318595,0.048508104,-0.011967016,-0.022548214,-0.016298251,0.033916507,-0.07847196,-0.030524386,-0.07145843,-0.042188313,-0.055706684,-0.048062354,0.04069534,-0.001892975,0.07428244,-0.018774042,0.029070877,-0.0032646502,-0.020261174,0.011597531,-0.0048256177,-0.02578037,-0.016914355,0.030722436,-0.066853285,0.045743633,-0.060617533,-0.0567347,-0.009724366,0.01325605,0.004148166,-0.027802689,-0.09431708,0.09125203,0.002963222,-7.3516e-34,0.014014044,-0.07685354,0.07739556,-0.0054463497,-0.0732408,0.1041694,0.016826482,-0.019928942,0.021280386,0.004562554,-0.0037851357,-0.0062658526,-0.11293038,-0.04370001,-0.043550193,0.03937076,-0.02682543,0.055361066,-0.023426548,-0.026795302,-0.098937854,0.10133093,0.0034386567,0.011976082,0.040373895,0.041633274,0.08958124,-0.011309604,0.0068425587,0.06675761,-0.0089097405,-0.012146723,-0.014209211,-0.06153126,-0.027311966,0.056224994,0.017750094,-0.02506427,-0.050033852,-0.058583852,-0.0115721915,-0.021485513,0.056501534,0.05348454,0.12244477,0.10793164,-0.024498316,-0.012399665,-0.13108887,-0.055649385,0.018993458,0.024483506,0.036237188,0.02342929,0.109684564,0.012717205,0.08681526,-0.029655492,0.019309457,-0.023175634,-0.016808392,-0.0045540845,0.01124681,0.031490233,0.09431968,0.01788706,-0.028139338,0.039102335,-0.009041695,-0.019754615,0.020635907,-0.0623376,-0.0593295,0.006366708,0.011599162,-0.040082753,-0.0934351,-0.051826376,0.0043886695,0.060667366,-0.038788587,0.011222355,-0.02749252,-0.025328822,0.00016069325,-0.025135227,0.055513415,0.06723707,0.033552323,0.053988185,-0.0054079415,0.056191362,0.01012345,0.007669983,0.029142782,-2.7927008e-08,0.05690124,-0.040131647,0.017857572,-0.12017721,-0.03412564,-0.06235988,0.016130162,0.07702783,-0.03131219,0.05312783,-0.019334035,0.09960971,0.045305654,0.012869581,-0.0018376907,0.03559792,0.010511315,-0.06493095,-0.0015310523,-0.0016019715,-0.066236794,0.017699322,0.028724676,0.005623888,0.003146686,-0.14609413,0.06663647,0.062503524,-0.033555973,0.04534647,0.028931964,0.046921533,-0.053088427,-0.108175986,-0.030448994,0.054685347,0.00057911617,-0.05266952,0.025843402,0.058068875,-0.033333924,-0.013253924,0.014799384,-0.020677678,-0.059445173,0.02072474,0.010659543,0.0030362117,0.012951941,-0.00828068,-0.043073226,-0.036730077,-0.09600355,-0.046197806,-0.1539894,-0.050566263,0.037163824,-0.028072188,0.09413081,-0.14001316,-0.046709917,-0.0027912173,0.084468365,0.018142473 +3.2.1.77,"A 1,6-alpha-D-mannan backbone remains after action on yeast mannan. This is further attacked, but slowly.",384,1.0,-0.020987302,-0.018481057,0.011783481,-0.09013991,0.001999081,-0.024914613,-0.07517436,-0.0038154908,0.018170355,0.11917987,0.11210036,0.017110387,-0.10920856,0.037467327,-0.06900795,0.0049440684,-0.07794127,0.018019404,-0.031666804,0.08326691,-0.023936743,0.05445627,0.068042144,0.03894739,-0.026250595,-0.076806374,0.0072611487,-0.01279412,-0.006414326,-0.1645488,-0.02650743,-0.0061294986,0.0011104433,0.0013835724,0.00361406,0.0838602,0.071078844,-0.031049363,0.07312607,-0.014250205,0.017664826,-0.10816982,0.02156016,-0.03349766,-0.03802658,0.0019467486,-0.11607385,0.045707107,0.07868965,0.015065845,-0.013497118,-0.07175776,0.011122455,-0.033066653,-0.004336639,0.054522067,-0.021032482,0.001156812,0.054201785,0.021456512,0.012252213,-0.009305782,0.025008906,0.057688188,0.04779438,-0.04849924,0.014036135,-0.05637476,0.010711643,0.07328445,0.051597983,-0.07637079,-0.06453194,-0.041892633,-0.01472333,0.067511134,0.022952748,-0.1514203,0.040837545,-0.0019454539,0.0002143326,0.073164314,0.076380506,0.049773414,-0.033568047,-0.045538004,0.01667266,-0.006213978,0.026427723,0.086790286,0.041125923,0.05714899,0.05150598,0.022286467,-0.021253768,0.022068063,-0.015436133,0.06939547,0.007933838,-0.0021911738,-0.012867485,-0.0020917214,-0.020561898,-0.050992414,-0.010575832,-0.00518855,-0.018855305,-0.04597635,0.013056153,0.02308796,0.067575626,-0.035550624,-0.014383138,-0.0046133567,-0.015207267,-0.0015279717,0.054768205,-0.020586915,-0.041842695,-0.07527591,-0.022691343,0.004770621,0.053885672,-0.013460878,-0.06951365,-0.0019591101,-0.048337296,-3.633863e-33,0.03130424,-0.054635447,-0.015522637,-0.0060924655,0.048208624,0.00942742,-0.02274505,-0.037834384,-0.10526717,-0.0074544847,-0.113852866,-0.02962805,-0.04853608,0.0618091,-0.066769555,0.046741597,0.037033994,0.049798947,-0.09555892,-0.048947744,0.014246255,0.09744131,0.007874791,-0.019389126,0.10497253,-0.010205192,-0.034007095,0.03957139,-0.07349781,-0.032699782,0.032171227,-0.043608524,-0.06713946,0.045686554,0.0018350685,0.039128248,0.043781403,0.0016867856,-0.02074193,-0.004865143,0.0009021941,0.04665409,-0.0410536,-0.03186363,0.0012789526,-0.0037638948,0.02598312,0.058565427,-0.047442112,-0.021800343,0.009311419,0.02556648,0.039949697,0.036916234,0.0067893527,0.030688388,-0.047970567,-0.008846966,0.03987975,0.07858271,0.021199593,0.0265151,-0.015522209,0.08089307,-0.023857422,-8.166369e-05,-0.08093613,-0.017169049,0.0047617257,0.032884248,-0.017141437,-0.023768052,0.057021376,-0.061938886,0.030943194,-0.047097377,-0.020614412,-0.016053228,-0.04408247,0.10244061,0.04951334,-0.04022789,-0.0028638581,-0.0053199157,-0.07808124,0.061093166,-0.00010782047,-0.1452093,0.009980464,0.032882374,0.03372224,-0.08394755,-0.12457023,0.0062306924,0.0071381745,2.1960443e-34,0.10623049,-0.054266218,0.06667572,0.0020175895,-0.09420202,0.09197308,0.057132144,0.05614934,-0.0631127,-0.07766172,0.057465505,-0.013886534,-0.04754199,-0.01581233,0.07428822,0.03183935,0.01619177,0.025482414,-0.038845155,0.032492902,-0.014710685,0.07408935,-0.0926692,0.043387275,0.04825959,0.0077443933,0.036112193,0.051126428,-0.022897469,0.006339689,-0.026596425,-0.0035253672,0.017516097,-0.02347279,0.00989904,0.087347694,-0.038548533,0.01820493,-0.024878833,-0.0035432647,-0.027685435,0.0089062555,0.011807691,0.028276183,0.037528403,0.035166763,0.019582335,0.067276165,-0.07053219,0.005261858,0.022976018,-0.04084803,0.074149475,0.03851574,0.03781967,0.0048155217,-0.0028740994,0.034452766,-0.001928497,0.031295676,0.014380764,-0.073129565,0.021134524,-0.026149532,0.008207117,0.052269183,-0.07195851,-0.030483695,0.052130707,-0.031030346,0.033117473,0.049177893,0.030705713,0.008509812,-0.011494659,-0.015679277,-0.09361822,-0.09494695,0.035432767,-0.027867742,-0.06205676,0.018454611,0.010544563,0.0074079563,0.064988434,0.026537508,0.102889,0.030743511,-0.037636217,0.06645274,-0.03088,0.0063379644,-0.07154918,0.033911098,0.019285224,-2.6040919e-08,0.10694042,0.0043612486,0.105735466,-0.061131116,0.04400494,0.016441911,0.042349122,0.057577174,0.044043284,0.018201234,-0.036481295,0.13756219,0.06950345,0.03643988,0.002379443,-0.031806935,-0.055083647,-0.036458623,-0.07183326,-0.05992978,-0.12171189,0.025962746,-0.028019127,0.0069725267,-0.048114702,-0.000992841,0.007839267,0.024706112,-0.0041452874,-0.0574524,0.022422686,-0.028407678,-0.03149211,-0.068737224,0.02167977,0.13368334,-0.069389954,-0.11871628,0.019652909,-0.03281552,-0.0633928,-0.073605955,0.048003227,0.011332028,-0.09946288,-0.0457319,-0.03293283,0.021032363,-0.0054091495,0.052497003,0.056814756,0.04521072,-0.074503504,-0.026003372,-0.07287616,-0.00751687,0.017803365,-0.0516261,7.1218616e-05,0.012280313,0.088256784,-0.15809521,0.04963656,-0.0744082 +3.2.1.80,"Hydrolyses inulin and levan, and also sucrose.",384,1.0,-0.0420138,-0.07777252,-0.09059536,0.024193248,0.063725926,-0.009936928,-0.007411803,0.029823884,-0.013965956,-0.016453868,0.034006268,0.042112924,-0.03961105,-0.006331258,-0.07441633,-0.002737862,0.0018801998,-0.036178835,-0.0197809,-0.014449956,0.07515375,0.0066229277,-0.015041219,0.06231643,0.018391008,-0.058110584,-0.0027540147,-0.0066613676,0.0038247048,-0.065780155,0.014113473,-0.034287684,-0.043954354,-0.05146586,0.032660462,0.12928748,-0.009208235,-0.057444856,0.014240535,-0.07348867,0.046714123,-0.06946064,-0.007845129,-0.027404234,-0.0070595164,-0.031859435,-0.050872345,-0.018005159,0.052398,-0.012231223,-0.031501967,-0.08424353,-0.0358353,0.04972247,-0.020837476,-0.08660035,-0.12321969,0.018531632,0.010379536,0.027759826,-0.039015993,0.09563231,-0.022384366,0.0038632755,-0.01678361,-0.036824398,-0.050124653,0.015881736,-0.035669483,0.027963517,0.014019732,-0.058686934,0.052599795,0.06515772,-0.04537033,-0.0640127,-0.022971338,-0.09048857,-0.012915439,0.036405593,0.002016751,0.0034438882,-0.023547318,0.10872146,-0.009287106,-0.011560445,0.0096616885,0.052536584,0.009815166,0.016617918,0.012486552,0.0044561327,0.050685707,-0.001798853,-0.023559835,-0.0140846595,0.033502128,-0.038389407,0.05650033,-0.04970244,-0.07178983,-0.000994758,-0.0003441723,-0.059601966,-0.053212486,0.05865375,0.034514602,0.024429848,0.0577363,0.02112003,0.033545915,-0.024631493,0.021465737,0.031798106,-0.03183564,0.019121835,0.06253611,-0.03622779,-0.010737751,-0.020368157,-0.03996433,0.009419894,0.1317618,0.009214607,-0.060933843,0.055407617,-0.06121943,-1.4920794e-33,0.00965997,-0.10933583,0.059843242,0.018075181,-0.014498792,-0.011336207,-0.04223888,-0.019675234,0.043066077,0.0079425,-0.11041185,-0.040712748,-0.024312109,0.04855466,-0.020783449,-0.09061745,0.0110164145,-0.03986458,0.02658026,0.029021531,-0.050126746,0.09192644,-0.010775643,-0.036937788,0.03379734,-0.06711907,-0.041843265,0.01476375,0.02710658,-0.033490535,0.105493486,-0.026689243,-0.06284676,0.06958236,0.03390418,0.08666755,-0.032585584,-0.019597877,-0.005714852,0.021491384,0.007286555,0.03016486,0.0013745032,-0.052564826,-0.03584692,0.023777096,-0.042171333,0.10164883,0.05067506,-0.024050774,0.06605281,0.012330838,-0.032075632,-0.038099296,-0.050989322,0.028620757,0.060438406,0.012680071,0.032521874,0.10770192,-0.08037686,0.02544943,-0.03902412,-0.045436736,0.021809151,-0.006040148,-0.09041887,-0.015037685,-0.036825042,-0.043572832,-0.20737539,-0.062465016,0.12135939,0.033918835,0.06175535,-0.031017546,-0.007661311,0.025161644,-0.065314025,0.06489719,0.048062436,-0.041378696,0.004551704,0.054574244,-0.076093085,0.087345116,-0.036265418,-0.034768224,0.046499867,0.034802765,-0.017614441,-0.029910661,0.007652045,0.013179497,-0.050467364,-2.1895191e-33,0.07262994,-0.12066908,0.06384038,0.015641013,0.046476785,0.057682853,0.061846834,-0.014506017,0.04509281,-0.020875972,0.07187774,0.008564973,-0.013889246,-0.004038066,0.017199004,0.106517546,-0.011634731,0.060261678,0.008417665,-0.08785681,-0.09993384,0.1524976,-0.008751327,0.017191265,0.06895804,0.050893515,0.014620885,0.001147525,-0.023273371,0.050123464,0.0037786425,-0.05082687,-0.045255445,-0.089298844,-0.033716794,-0.0057357815,-0.010189528,-0.097216316,-0.062860936,0.0017456132,-0.026453221,0.040649008,0.10470689,0.09506688,0.06439981,0.052113827,-0.09353294,-0.00088922714,-0.06606204,0.066908166,0.030066915,-0.026106417,-0.029146327,0.050809868,0.043813996,-0.050724722,0.02032765,0.041572336,0.0177264,-0.038036995,0.0022777838,-0.035217408,0.0068206424,-0.0013224764,0.024056226,0.0007026595,-0.07908426,-0.06404867,0.03174499,-0.004339837,0.00979526,-0.052806754,0.009761288,0.017644204,0.013241663,0.0072719655,-0.07568027,-0.08104134,-0.0030560074,-0.025062624,-0.03199548,0.10260619,-0.055104315,-0.031230774,0.01579485,0.004645051,-0.03420045,0.03730988,0.033523817,0.019914612,-0.017325083,-0.007996922,-0.054344643,0.03751329,0.08526421,-1.9341526e-08,0.018434638,-0.061867073,0.016300615,-0.00025911603,-0.07736054,-0.018743515,0.050828606,0.058149066,0.07316491,-0.018090684,-0.0032484597,0.13551314,0.009814364,-0.063825265,-0.03889033,-0.029841378,-0.016798908,0.06445515,-0.0110036,0.010279719,-0.061441068,-0.0025815251,-0.095672436,0.056159597,0.026016174,-0.07857386,0.029248785,0.0742871,0.01180979,0.015370706,0.04564408,0.036189586,0.07972676,-0.1252062,0.0009692345,0.06976746,-0.0040159137,-0.038205486,-0.012408994,0.004554509,0.014807512,-0.01502122,-0.007267199,-0.027599588,-0.055221003,-0.0056665163,-0.0017419776,0.09490454,-0.011491177,0.0026103419,0.039598625,-0.017379744,0.017758721,-0.0009585346,-0.011999318,-0.02849948,0.015905738,-0.030405914,0.02384313,-0.06138769,0.017581452,0.025275083,0.237953,-0.010323359 +3.2.1.81,"Also acts on porphyran, but more slowly [1]. This enzyme cleaves the beta-(1->4) linkages of agarose in a random manner with retention of the anomeric-bond configuration, producing beta-anomers that give rise progressively to alpha-anomers when mutarotation takes place [6]. The end products of hydrolysis are neoagarotetraose and neoagarohexaose in the case of AgaA from the marine bacterium Zobellia galactanivorans, and neoagarotetraose and neoagarobiose in the case of AgaB [6].",384,0.99999994,-0.07507233,-0.09422584,-0.032816894,0.027873652,0.008718685,-0.014843204,0.010398666,0.040786006,0.073897436,-0.028316675,0.054251347,-0.009577408,-0.09348507,0.07442415,-0.09483165,0.06450318,-0.06983171,0.030416174,-0.034180034,-0.0073803654,0.06259675,0.022302138,-0.07053712,-0.009570891,0.038258575,-0.04547141,-0.010878006,-0.06967176,-0.018855898,-0.083869435,0.024230596,-0.019483743,0.11326122,0.010084461,0.06739741,0.06281379,-0.018243773,-0.075971164,0.028067421,-0.018699193,0.12851141,-0.021654291,0.0056648236,-0.04056945,-0.024983564,0.021867644,-0.0021264874,-0.008358038,0.021042582,0.0062494357,-0.07813328,-0.1414274,-0.05788434,-0.009072811,-0.04211132,-0.024898514,-0.0039333743,-0.10138259,-0.019939573,0.037684716,0.06951974,0.01056825,-0.0587382,0.03119565,-0.029548064,-0.09116277,0.08392196,-0.03913828,-0.059606045,0.005001234,-0.033685166,-0.06653897,0.00931501,0.0056365314,-0.03094921,0.006176374,-0.041040163,-0.034141697,0.05163458,-0.015543078,0.024501678,0.007414403,0.05554633,0.0026473769,0.0039820164,0.0069116857,0.03883017,0.02677855,0.047753878,0.046450444,-0.0476057,0.012223539,0.0058044414,-0.023157207,-0.007701051,0.016952842,0.027971273,-0.07543214,0.023229055,-0.011006779,-0.024393946,0.010663124,-0.0016699298,-0.054499954,-0.059372276,0.018307904,-0.0015443262,0.09683147,0.030820504,0.062201414,-0.019144306,0.021354362,0.06680688,0.016258644,-0.06103114,0.05315404,-0.00464677,-0.009962063,-0.048260838,0.0019368806,-0.011617719,-0.06537991,-0.0023088185,0.08008425,-0.00085405214,0.08031415,-0.09980345,4.4326445e-33,0.06428633,-0.02363369,-0.035413433,-0.030610403,-0.0009761162,-0.00033752958,-0.10684414,-0.03097986,-0.009974632,-0.026066894,-0.08983465,-0.04714135,-5.4223506e-07,0.00980069,-0.006639206,-0.0037984871,0.05193294,0.034686558,0.02483231,0.009066482,-0.0019995319,0.045665532,-0.057049688,-0.042091537,0.080129914,0.0012539283,-0.019782444,-0.07405533,0.0026306664,0.004483989,0.024777452,-0.03930289,-0.11585837,0.084437445,0.07412916,0.024377592,-0.043730494,-0.03499353,-0.032354802,0.01902012,0.0046300474,0.041677047,-0.041258283,0.0066942777,0.114923164,-0.043761484,-0.02351585,0.1280946,0.037219886,0.07235828,0.0077289552,-0.026915742,0.06904362,0.055896513,-0.048389282,0.046109363,-0.085521586,-0.011495966,-0.017695056,0.049899615,0.022888498,0.08465396,-0.02837425,-0.042907905,-0.056293912,0.0062730047,-0.03083325,0.025734128,-0.01916173,0.056186683,-0.050264254,0.0052981977,0.035466865,0.07273797,-0.04036533,-0.055894624,-0.007690669,0.002642282,0.0008636287,-0.011671373,0.019695709,0.0011889613,0.07684142,0.016285101,-0.08263416,0.030425526,0.03154013,0.030322224,-4.2704924e-05,0.01783213,0.1221012,-0.056524687,-0.08555943,0.030135594,0.022092823,-4.721145e-33,0.08084153,-0.09020677,0.009214663,-0.07045295,-0.03929362,0.014203273,-0.031116635,0.010312851,-0.031756993,-0.029455319,-0.044016663,0.097067654,0.00977,-0.10876624,-0.04056832,-0.05510377,0.08773883,0.04591623,-0.016553447,-0.058787957,-0.055779662,0.07043071,0.076121494,-0.056589678,0.043564744,-0.009896784,0.020169947,0.10077701,0.0089798095,0.058133673,0.05294171,0.03711398,0.0008471179,-0.12195736,-0.03058007,0.030814676,-0.03276851,0.013410068,0.050136674,-0.0013212669,0.05118054,-0.0020206901,0.00407966,0.08449699,0.079174116,0.090493485,-0.023000443,0.0164143,-0.020925185,-0.037706275,0.022367746,-0.04074035,0.069433,-0.015837178,0.014044704,0.01707986,0.057672985,0.0044605453,-0.10725273,-0.050822802,0.012339887,-0.012426891,0.070122756,0.0018740994,0.03516441,0.052841935,0.0068158535,0.08674553,-0.013611184,0.05952065,-0.008678823,0.040670667,-0.09546308,0.022391371,0.013404776,0.024824874,-0.10221618,-0.11648168,0.0075579104,-0.05381132,-0.08008988,0.08115691,0.012184097,-0.078784876,0.013280426,-0.04097844,0.06745122,0.10726273,0.012427567,0.03700794,-0.008456242,-0.008491054,-0.006389558,0.06469018,0.0346415,-4.622549e-08,0.026836118,-0.021476667,0.019189041,-0.054999392,-0.027195279,0.05613325,0.021242606,0.05089317,0.0578135,-0.038363732,-0.10647287,0.11021772,0.015757715,0.038669866,0.053114448,-0.013629584,0.038777385,-0.05526773,-0.057003718,-0.046634644,-0.09816788,0.011883752,-0.09788209,0.07579615,-0.08589184,-0.056525853,0.03849253,0.049972754,-0.019707961,-0.018615892,0.018586459,0.07770444,-0.0027057657,-0.07163919,-0.074766695,0.048845492,-0.015033644,-0.0572767,0.044846337,-0.00367238,0.04593333,-0.02465262,-0.014417447,0.022602133,-0.015199876,0.028419174,-0.013545017,-0.050186817,0.03913123,0.0025241948,0.1153714,0.0030397389,-0.097189285,-0.01902065,-0.07009824,-0.06150936,0.007666027,-0.044777356,0.040000062,0.0030228738,-0.006553789,-0.058256354,0.11719632,-0.01073886 +3.2.1.82,"The enzyme, characterized from bacteria, hydrolyses the second alpha-1,4-glycosidic bond from the non-reducing end of polygalacturonate, releasing digalacturonate.",384,0.9999999,-0.04110915,-0.116358414,-0.050493196,0.011097213,-0.107006975,0.035899308,-0.031566743,0.008493329,0.036082167,0.024175309,0.05296066,-0.012491285,-0.11639036,0.05232183,-0.08772756,0.04155668,-0.028722221,0.027431058,-0.01571641,-0.011391949,0.12861538,0.019487938,-0.08518458,-0.01762555,0.050674632,0.048119523,0.00781952,-0.06392373,0.008220149,-0.051188696,0.014714914,-0.04777854,0.025197241,-0.0038854782,0.09086755,0.10558359,-0.09903792,-0.10874718,0.046922125,0.029280411,0.07722465,0.016314223,0.0440343,0.0024902674,-0.037228335,0.014252099,-0.010623404,0.018623631,0.005561548,-0.0015181476,-0.046039898,-0.061213978,-0.049403306,0.0042711115,0.042042885,0.052158155,-0.0100637,-0.025170848,-0.060772836,0.081767224,0.053708065,0.0674465,-0.0178608,0.024855647,-0.08151592,-0.040887382,0.039351854,-0.05668774,0.0016521146,-0.01645572,-0.036829673,-0.020544535,0.01464417,-0.0790679,0.0153482,-0.05788448,-0.006191439,-0.030981792,0.0754523,-0.049818736,0.08741251,0.013701492,0.045473635,0.09194838,-0.04550163,0.010276791,0.05619378,0.00023468482,0.046803657,-0.008462208,-0.03192362,-0.0147218015,-0.01874963,-0.08517464,-0.0014315977,-0.03966482,-0.009452797,-0.03269497,0.029444797,-0.003591532,0.009512043,0.028486278,-0.058180947,-0.151475,-0.044050694,0.051264454,0.03248854,0.045679368,0.07694716,0.065073825,-0.028770152,0.08665265,0.022035373,0.058511972,-0.010181482,0.05565375,0.06604355,0.010986729,-0.01058963,-0.002234155,-0.013216837,-0.09387963,0.03444353,-0.02229459,-0.103222094,-0.019182969,-0.10076465,-6.4890264e-34,0.08795314,-0.0044737007,-0.03506377,-0.07831877,0.023892196,-0.024272507,-0.04140288,-0.03233434,-0.037015326,0.031280015,-0.08961525,-0.04780584,-0.03192782,0.1649848,-0.03006547,-0.013031694,-0.017200701,-0.028385893,0.04645281,-0.018452901,0.031595126,0.097779855,0.01155909,-0.0019128167,0.03103069,-0.00094368553,-0.0667499,0.01840017,0.04656047,-0.03358819,-0.003954135,-0.06413397,-0.116401844,-0.009163989,0.09282198,0.02956051,0.006316689,-0.05467711,-0.026578037,-0.0053770477,-0.027032899,0.023059089,-0.013699114,-0.06767813,0.07327834,-0.011644274,-0.059778064,0.06697434,0.03832033,0.029189985,0.031864777,-0.031151962,0.11473513,0.012376448,-0.08081686,0.0070416387,-0.013132216,0.036872722,0.009788134,0.023924787,-0.040786233,0.037948083,-0.025389688,-0.054113977,0.007034572,0.06200195,0.0071475008,-0.0087572355,0.036497876,-0.005787964,-0.054307107,-0.031184232,-0.049220145,-0.045346525,-0.025794955,-0.07835236,-0.0035682665,0.00028240745,0.012102383,0.0065964265,0.0041659195,-0.025134316,0.04393403,-0.004392311,-0.04699585,0.023187716,0.031676598,0.039250653,0.059560735,0.07171973,0.022336718,-0.054802354,-0.02430989,0.062429197,0.04370843,-1.0761562e-33,0.061293002,-0.1120903,0.0111729605,0.017037602,-0.05383183,0.016990324,-0.0030597334,0.041888908,0.0011124044,-0.012683781,0.042158503,0.061356373,0.053783156,-0.028992184,0.04551687,-0.027974362,-0.025452279,0.07641189,-0.018103955,0.010075543,-0.008252363,0.064049736,-0.054444313,-0.028200561,0.11993002,0.025022417,-0.045131862,0.079805724,-0.03230569,0.010299609,0.013712051,-0.01214812,-0.03985013,-0.11076453,-0.028497277,0.08473904,-0.053479426,-0.019780038,0.003400691,0.037369713,0.02030519,0.04248415,0.08972495,0.115654215,0.059225537,0.06647381,-0.0760538,-0.0106717395,-0.039485972,0.009430138,-0.023672638,-0.023503225,-0.00028240524,0.021819634,0.045688722,0.035260227,0.035195753,-0.017111165,-0.060490444,-0.07179342,-0.06822509,-0.09521963,0.024705946,-0.0022218602,0.06339245,0.03917645,0.016296202,0.04433084,0.021175185,-0.0033870323,0.031548094,0.06443875,0.026983276,0.04417766,0.0019617353,-0.015334962,-0.1494248,-0.05130706,0.040135894,-0.029602801,0.033929467,0.0118851755,-0.045350503,-0.05151274,0.023991512,-0.063311845,0.12162085,0.13416836,0.004793657,0.05725339,-0.0028463795,-0.013345794,-0.028886743,0.06963729,0.032648653,-3.0844756e-08,0.0417729,-0.026203215,0.016724775,-0.08340484,0.006131905,0.013147871,0.004420542,0.070331626,0.030130493,-0.064346395,0.010664169,0.047415018,-0.038693342,0.021541335,0.027532028,0.034197535,-0.03130349,-0.019258,-0.0069091655,-0.016682692,-0.07082902,-0.04229557,-0.104239054,0.061964944,-0.03640731,-0.08369752,0.036005702,0.07546641,-0.086407535,0.02727081,-0.012449422,0.10044955,-0.0045970827,-0.0661316,-0.08231784,0.08782768,0.016702447,-0.030831998,0.038220678,-0.011556872,0.0047964,-0.01363448,-0.04410736,-0.0018907931,-0.028037366,0.0226122,0.0494575,0.015084947,-0.014062213,0.012336449,0.00519233,-0.008790535,-0.033380162,-0.04598419,-0.10983101,-0.024662916,0.0018514085,0.003073208,-0.029777115,-0.03156664,-0.057125345,-0.0017520745,0.15816174,-0.029687354 +3.2.1.83,"The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate [5]. Unlike EC 3.2.1.157 (iota-carrageenase), but similar to EC 3.2.1.81 (beta-agarase), this enzyme proceeds with retention of the anomeric configuration.",384,1.0,-0.01120526,-0.080716275,0.007480195,-0.01550075,0.068720184,0.003187493,-0.032881293,0.030321307,0.04771751,-0.06329114,-0.01088463,-0.029743217,-0.097452395,0.0605768,-0.055586774,0.05826638,-0.0073362817,-0.010307112,-0.013573193,-0.04107891,0.09293628,0.009889059,-0.018616881,0.02755651,0.012228428,0.060546108,0.009506133,-0.04744232,-0.060207743,-0.10554855,0.023833385,-0.06644451,0.12504189,-0.08713966,0.06430345,0.054470394,-0.03232573,-0.08178544,-0.029413378,0.0057392213,0.05147351,-0.05340763,-0.001497592,-0.058001064,0.051405888,-0.03616595,0.022899795,-0.037456438,0.022870943,0.0115161,-0.024703357,-0.10373902,-0.073482946,0.03947537,-0.02747304,-0.03415553,-0.039616935,-0.018764349,-0.037191335,0.04663107,0.069387585,0.08588562,-0.043284174,-0.017821841,-0.04377006,-0.04789697,0.08415814,-0.09155944,-0.0744612,0.014025286,-0.10465902,-0.11743241,0.0062691174,0.061132777,-0.018920802,0.0016967234,0.027776673,-0.07852659,0.058688205,0.0037278186,-0.02569183,-0.017222492,-0.01771538,0.033269845,0.0054625934,0.015548013,0.0053429618,0.02953099,0.03434593,0.012101114,-0.012462414,-0.015985223,-0.0068304753,-0.006220946,0.048538562,0.019634267,-0.008430521,0.02907906,0.059013616,-0.047031227,-0.039174344,0.03228256,-0.046104554,-0.100254185,-0.055864032,0.03143222,0.028804995,0.11561502,0.07867437,0.06696619,-0.06610746,-0.03765476,-0.01607661,-0.018403372,-0.0467947,0.10415931,0.03744038,-0.038949113,-0.020437324,0.01915531,0.011750438,-0.05419044,0.10653731,0.12901774,-0.0028299787,0.09726367,-0.06822896,8.516067e-34,0.049322765,-0.018681226,-0.012540349,-0.06462969,-0.060145278,0.049702972,-0.09180656,0.04407926,-0.013522253,-0.044217035,-0.07621738,0.048987113,0.032381825,0.036592208,-0.019403175,-0.019920716,0.054072447,0.0039851977,0.038596667,-0.040999163,0.0021883557,0.092205346,-0.07317382,0.05677139,0.054430753,-0.051368468,0.0265347,-0.010702423,0.042191714,-0.0013477005,0.040968694,-0.102540106,-0.023319848,0.024265526,-0.015819006,0.056204103,-0.029184261,-0.024967056,0.021733006,0.07967916,-0.020987216,0.060857676,0.045593306,-0.07044957,0.022270985,-0.058072705,-0.04631467,0.062180042,0.0665767,-0.0044704797,-0.013858262,0.016794141,0.052817054,0.031429004,-0.035200346,0.008744988,-0.064838134,0.066002145,0.010540889,0.041092146,-0.05505505,0.09392654,0.0049879868,-0.06587563,-0.037423108,0.033363603,-0.025225978,0.07773283,-0.028164482,0.014801121,-0.13158308,0.06515179,0.101993136,0.0155713,0.036685135,-0.05597141,-0.020230573,0.03802656,-0.038468532,0.014440917,-0.06592604,0.007560674,0.059484124,0.01770275,-0.052682042,0.06371907,0.0029047602,0.043268982,0.020382868,0.058394246,0.021232408,-0.048896562,-0.08446353,0.044232752,0.00083157537,-1.8887478e-33,0.056820426,-0.08261515,-0.027496178,-0.053126145,-0.004501224,-0.0016772171,0.004770976,-0.02660365,-0.016831841,-0.053239208,-0.007131686,0.0062994882,0.02304009,-0.13140438,-0.02674349,-0.026023285,0.0036568928,0.042288136,0.023068728,-0.023175932,-0.0120061105,0.09434542,0.05645159,-0.034606375,0.04385344,-0.015837612,-0.0038220482,0.02424914,0.064134,0.038754653,0.013941646,0.002163318,0.006089485,-0.10665097,-0.078609206,0.06420695,-0.11574162,0.008165853,0.06089576,0.043154523,0.021796823,-0.00901034,0.008790153,0.06348638,0.02564309,0.09176626,-0.009411534,0.024510497,0.02850532,-0.021384465,0.014724759,-0.019231167,0.0062437793,0.038738444,0.044188444,0.0131697515,0.054755535,0.021405635,-0.10064777,-0.026716117,0.001534584,-0.0005659686,0.07163583,-0.082527004,0.010346431,0.08616898,-0.04853973,0.038064502,0.011359621,0.06207125,-0.016403096,-0.05023862,-0.05255381,0.040448118,0.013480803,-0.050209794,-0.07519704,-0.02036706,-0.0044236477,-0.05596174,0.018887851,0.07816034,0.006207805,-0.09981893,0.004841394,0.002855199,-0.012297847,0.08740799,0.03667197,0.02799293,-0.027154071,-0.00438208,-0.0924853,0.062783346,0.010755705,-4.0610825e-08,0.029884763,-0.044573795,0.097278,0.024788883,0.010924671,0.06841161,0.070525594,0.11371132,0.018587215,-0.009367399,-0.03351969,0.07522254,-0.042806137,-0.03404003,0.035428565,-0.032040786,0.04579596,0.021100285,0.0036597669,-0.02153539,-0.10962498,-0.014926071,-0.05486074,0.018265912,-0.052220676,-0.008776524,0.05595463,-0.040198375,-0.061952386,-0.0014767566,-0.010388321,0.03919826,-0.004104217,-0.042486526,-0.023015093,0.030113585,-0.042955466,-0.019989021,-0.07636274,0.034326673,0.032988213,-0.06106836,-0.016457213,0.0074562905,0.052364126,0.004776784,-0.012280843,-0.039256845,0.03455029,-0.023205785,0.08186299,-0.10089736,-0.049162216,-0.01692598,0.003804975,-0.006065163,0.01388341,-0.12187873,0.02123007,-0.014282391,0.052058723,-0.035147823,0.18802074,-0.014793802 +3.2.1.84,Does not act on nigeran.,384,1.0,0.03416156,0.0111906035,-0.018374972,-0.078191645,0.02704596,-0.058177605,0.026705546,-0.11544301,-0.047335286,0.008778692,0.011543892,-0.0055712555,-0.01914309,-0.035906155,-0.06580665,0.026510477,0.008277991,-0.00946788,0.025790827,-0.00016415796,0.016174292,0.017237425,0.123986855,-0.009476491,-0.04718635,-0.056427743,0.04543242,-0.030559389,0.008260386,-0.02753029,0.05686119,0.056114115,-0.04902881,0.0763597,-0.012290219,0.0077833333,0.016350416,0.045545384,0.040352717,-0.03780061,0.040946193,-0.036942054,-0.02167267,-0.07273315,0.109356865,0.00037808757,-0.03568023,-0.01654617,-0.020520167,-0.06761975,-0.072588384,-0.041473337,-0.078009054,0.030359771,0.0037364722,-0.02961108,-0.06024128,0.0076092584,0.06788219,-0.041933216,0.03314319,0.015010887,-0.014987466,-0.011562135,0.009628884,-0.025813216,0.0022392368,-0.009434234,-0.043456398,0.0010460821,0.062167414,-0.006882045,0.034457695,0.060454912,-0.089782715,0.03442236,0.051136903,0.054066688,-0.017288867,-0.024352392,-0.09134518,-0.02083666,0.10748069,-0.0013826602,-0.0052796667,-0.049019136,-0.033954322,-0.041881416,-0.06498895,0.025837537,0.05351009,0.07325976,0.10529715,-0.025106542,-0.0012555427,-0.09164524,0.067563295,0.06047419,-0.07144517,0.09328975,-0.033190887,0.0065838876,-0.014156045,0.004578591,-0.03950746,0.054875042,0.020195467,-0.04336078,-0.032475486,0.01953244,-0.09529234,0.03775536,-0.0071399393,0.049911365,-0.0008515678,-0.043414384,-0.023608802,-0.039316285,-0.07688917,0.030074233,-0.0026903094,0.0074406625,-0.040692337,0.048027024,-0.0766024,-0.036202878,0.09717729,-3.6214858e-33,0.0005086441,-0.09245891,0.0150999455,-0.13103203,-0.01699013,0.072519414,-0.02138488,-0.009773038,0.051155087,0.02813513,0.0020207802,-0.02731465,0.06415374,0.02818607,0.025108796,0.09551742,0.018340286,-0.0025241992,0.05385469,0.023198346,0.052807454,0.07747502,-0.07793005,-0.0022569548,0.008871956,-0.019709118,-0.030761765,-0.050214026,-0.052911036,0.021515373,-0.04856459,-0.03388047,0.04325808,0.0010650621,-0.011998187,-0.010614519,-0.06256459,-0.02864654,-0.108690694,-0.0041324343,-0.005989552,0.062775835,-0.022103406,-0.008094418,-0.02684629,-0.0027214081,0.13568139,-0.035494052,0.03326774,0.07351827,0.04775874,-0.033938814,0.001922063,-0.056721345,0.016302858,0.01712528,-0.026144015,0.04482664,0.014169333,-0.03435752,0.049133595,-0.094745725,-0.04330315,-0.02280626,-0.049156357,0.014851184,-0.0148665765,0.005078734,-0.00824828,-0.09882668,0.044550303,0.018195007,0.029333508,0.06509297,-0.047657844,-0.041167147,0.050021984,-0.027963355,0.03946434,0.046047393,-0.022425426,-0.038148277,-0.020346133,-0.09628069,0.022616725,0.085192606,0.0026068287,0.051981952,-0.012891813,0.0045517436,-0.0044018985,-0.0057165264,-0.06144229,0.013163248,0.005711187,4.6690388e-34,-0.0054844837,0.023640908,-0.04301753,0.052528456,0.050808936,0.06131585,0.0439911,0.045402866,0.057896018,-0.0404559,0.080188915,-0.0834812,0.0821252,0.04327523,0.04624985,0.012787478,-0.012600823,0.09016762,-0.08686871,0.027689781,-0.037590455,0.10366137,-0.058012284,0.0993615,-0.09698074,0.03581182,-0.080364004,-0.008523149,-0.02916601,-0.026826447,0.03367501,0.030786216,-0.123208396,-0.007507181,0.010296624,-0.019848997,0.0022894146,0.031316187,-0.083932936,0.010337775,0.08301519,0.12082134,-0.016165704,0.045751896,-0.022043321,0.062300317,0.03291757,-0.007921666,0.008896154,-0.10287113,-0.05653332,0.05192092,0.07862525,-0.009682273,0.114313506,0.019649014,0.0367474,-0.05238657,-0.04340608,-0.028934281,0.013887903,-0.036173046,0.009587906,-0.07582149,0.075943224,0.09339807,-0.06852605,0.085143514,0.18549211,0.005372035,0.065371335,-0.12773265,-0.0056707133,-0.079749994,-0.07901512,0.06889755,-0.024754273,0.03034183,0.029215116,-0.08629297,0.10758114,-0.057534102,-0.027029004,-0.018534133,-0.026774684,0.070875585,0.024029937,-0.06304929,0.02015421,0.09872939,-0.023091113,-0.07397837,0.021187862,0.046555478,-0.015399998,-1.4057087e-08,0.03105792,0.013881106,0.077649,0.026678573,-0.035612475,0.08288703,-0.026874393,-0.08825338,0.0069124247,0.08034981,-0.010386251,-0.035205044,-0.027509162,-0.059468273,0.013893416,-0.04447174,0.068388745,0.020580279,-0.025624674,0.0035949708,-0.10053049,-0.016623626,-0.061886802,0.054180544,0.04258274,-0.027891254,0.028904865,-0.04848767,0.053175494,0.03094154,0.003910348,0.071703054,-0.06565652,-0.0070966007,-0.029527657,-0.039383456,0.06305437,0.0116561055,-0.07167895,-0.057294518,-0.030765885,0.02572483,0.026443297,-0.01669239,-0.019275341,-0.014985322,-0.000505524,-0.0142046735,-0.07690284,-0.023866555,0.03534325,0.035428673,-0.03586676,0.061872922,0.029269503,-0.019357927,-0.0183768,0.011760927,-0.013888016,-0.023910634,0.037561417,-0.08087321,-0.017798629,-0.014872719 +3.2.1.86,"Also hydrolyses several other phospho-beta-D-glucosides, but not their non-phosphorylated forms.",384,0.99999994,0.008609469,-0.10489798,-0.047660977,-0.0018346083,0.033476904,-0.014674843,-0.010975527,-0.03455675,0.08375345,-0.0026123829,0.012184258,0.07788991,-0.009151254,0.037244696,-0.062248684,-0.015789978,-0.029961204,0.011991215,-0.049521156,0.0073405053,0.086648874,0.019599123,-0.012892706,0.046843793,0.06271118,-0.013236124,0.06958662,-0.019753804,0.009088192,-0.04233055,-0.050112177,-0.0047543976,0.0017445934,-0.0071202074,0.04136091,0.100145645,-0.04287079,0.022948453,-0.008429645,-0.03424347,0.039912824,-0.026977472,0.06004677,-0.0036645895,-0.05133935,-0.0039475663,-0.07416301,-0.0010578677,0.023653409,0.018116295,-0.0008480951,-0.07994614,-0.10193656,0.08445662,-0.061288867,0.037108436,-0.10867147,0.03549353,0.014452681,0.03794581,-0.053457133,0.064068876,0.017510526,0.084493294,-0.04554025,0.0022604377,-0.018397242,0.006908764,-0.060486156,0.0003328807,0.019675393,-0.021402933,0.03950319,0.0029710624,0.016730115,0.033609353,-0.0027400318,-0.017973496,0.0034458938,-0.049417168,0.045845877,0.029624635,0.07203253,0.055363428,-0.017763767,0.04977029,-0.035788517,-0.022828942,0.010276893,-0.023118488,-0.0104268715,-0.07052343,0.040229972,-0.024104323,-0.0053666984,0.0021169868,0.07219045,0.015159214,-0.016088694,-0.064149015,-0.04592372,0.036674727,0.04209451,-0.04152961,0.022416642,0.06756128,-0.014182405,0.043023296,-0.017058564,-0.041584793,-0.03129585,0.025425564,0.05035253,-0.034964304,-0.04430295,0.0013496794,0.012344778,-0.043729983,-0.076972134,-0.011631102,0.0058668302,-0.071024396,0.047971524,0.037906025,-0.12703098,0.022051202,-0.013807738,6.615931e-34,0.044034906,-0.006342018,0.083596624,-0.033154286,-0.015251159,0.0034483948,-0.06652139,-0.111742355,0.049628004,-0.037193336,-0.09034723,-0.007735944,0.01183809,0.0714701,0.02346279,0.056424584,0.04205414,0.020450087,0.07603082,-0.026741324,0.02834588,0.08248513,-0.04807659,-0.0433207,0.011777201,0.026924636,-0.032725655,0.03242512,0.053895645,-0.020233821,0.001619627,-0.056291264,-0.01724039,0.086686924,-0.010703801,0.06607041,-0.08170899,-0.055027135,0.045218274,-0.027803777,0.022185214,-0.07691963,-0.063773975,-0.07383062,0.026703501,-0.045544222,-0.0346304,-0.027197579,-0.060557313,0.048142646,0.027468901,0.023773672,0.0050264276,0.042883985,-0.07209833,-0.03919195,0.010002091,-0.02720116,0.0096630035,0.07466415,-0.061263148,0.095018774,-0.05727293,-0.022197926,-0.034191445,0.02417077,-0.101195194,-0.036808543,-0.073750764,0.0063727964,-0.044627905,0.0047471668,0.06997372,-0.004329129,0.06277906,-0.106713645,0.07093912,-0.0139417,-0.026334034,0.081979215,0.055534314,-0.037652966,-0.027684044,0.099396,-0.016665872,0.084352635,0.02191433,-0.028757283,-0.042389598,0.039473765,-0.018514145,-0.023325508,-0.06582841,0.0461456,0.0066189766,-3.542309e-33,0.064994775,-0.10725765,0.050764423,-0.06250009,-0.008010653,0.045613043,0.08955577,-0.050963566,0.050899647,-0.07305899,0.010579008,0.0017438491,-0.14925103,-0.06829024,-0.07142639,-0.03747451,0.015088174,0.09910859,0.028204024,-0.004922364,0.0019264063,0.07278791,0.0069506634,0.047957674,0.1060777,-0.04888933,-0.031282682,0.062270384,0.0035585905,0.10472874,0.053670555,0.05483163,-0.028127333,-0.08858798,-0.04049279,0.021922082,-0.07252769,0.005386464,-0.0018381171,0.0019351558,-0.02036134,0.0059042107,0.101189956,-0.019460274,0.12459685,0.16106002,-0.041545745,0.0003441942,-0.048956208,0.002390166,-0.0107847825,-0.023827553,-0.08333814,0.079808615,0.102142625,0.04741468,-0.014334157,0.06554554,0.018771075,-0.11162902,-0.040817834,-0.05908912,-0.02406296,-0.066716194,0.05305833,0.024318032,0.017946308,0.044669975,-0.021146858,0.038306553,0.03873405,-0.030780813,-0.011453609,0.010499354,0.03494678,-0.032592885,-0.10324388,-0.06473567,0.0042306837,-0.04241349,-0.0009999422,0.08121783,-0.010434656,-0.040958475,0.0507365,-0.03550807,-0.0020112451,0.034332417,0.008381157,0.07041789,0.0012518975,-0.0005475258,0.00019828991,0.039210957,0.07704963,-2.8521276e-08,0.08951941,-0.013432269,0.006323665,-0.094760135,-0.015442227,-0.012716969,0.07513332,0.030362299,0.023844209,-0.031203177,-0.04233442,0.027460227,0.0046609025,-0.04646912,0.007917036,0.050798073,-0.016806338,-0.0005157996,-0.0039287424,-0.009196396,-0.041429266,0.0036561254,-0.09146334,0.065845646,-0.018683262,-0.04111894,0.1206951,-0.04792243,-0.017387532,-0.014344346,0.04461299,0.024971863,-0.020180244,-0.102341786,0.024445958,0.045071173,-0.029096847,0.028435485,-0.0126138,0.026849125,-0.051001348,-0.004960926,0.040071845,0.043801025,0.034261376,0.017839279,-0.033004437,0.022258198,0.020783199,0.00067295757,0.04191797,-0.031058358,-0.059620224,-0.13165581,-0.11423341,-0.03149593,0.053973768,-0.05090703,-0.006506592,-0.11438992,-0.0038353202,-0.024157071,0.1708642,0.020165756 +3.2.1.87,"Hydrolyses the galactosyl-alpha-1,3-D-galactose linkages only in the complex substrate, bringing about depolymerization.",384,1.0,-0.0032202625,-0.14484137,0.008224941,0.0033835585,0.02018777,-0.04757123,0.01820854,-0.04080868,-0.032481615,0.0007532966,0.022944674,0.055974457,-0.062252868,0.07308831,-0.027095184,-0.006285855,-0.032037333,0.061527792,0.012065842,0.107991986,0.14324011,-0.09115139,-0.04350939,0.043187253,0.10108965,-0.036989946,0.057120822,-0.055655718,-0.01720351,-0.09368643,0.042424373,-0.02845672,0.012837375,-0.020746842,0.041879583,0.041867264,0.01127823,-0.07241093,0.011937251,-0.0097692255,0.059328496,0.0009954545,0.039078757,-0.0356615,-0.051093917,-0.0033584672,-0.079811536,0.04797133,0.010709481,-0.02892262,0.03925971,-0.040416155,-0.07274983,-0.055637408,0.0133497985,0.10539205,0.00990098,0.041003052,-0.025541069,0.030154128,0.10356273,0.07988749,0.003265774,0.015808312,-0.04671972,-0.034309015,0.03989827,0.024525903,-0.0019080134,0.06295519,-0.0885578,-0.022203477,-0.04400968,-0.06552882,0.074657485,0.030736856,0.017656282,-0.035362702,0.04809763,-0.015857935,0.017221587,-0.042183515,0.04832647,0.055828854,-0.023780068,-0.019446691,0.04402156,-0.0018042256,0.0036909876,-0.029565038,0.012392723,-0.013564941,-0.04005789,-0.03823226,0.013090739,0.048733328,0.0140336715,-0.033572346,0.05557547,-0.026465112,-0.012072338,-0.0021647546,0.10566172,0.0147943515,0.0124775,0.065275855,-0.028227687,0.068165526,0.013088941,0.059280593,-0.052485555,-0.04311214,0.08603389,0.022384064,-0.097521104,0.05327032,-0.03474096,-0.021937944,0.026586013,-0.094698764,0.05146015,0.0377202,0.04281962,0.010455906,-0.0515911,0.08034535,0.03200643,-1.1023785e-33,0.059881948,0.020895597,0.032694265,-0.0582294,-0.038558003,-0.04633821,-0.07437359,-0.016470632,-0.03924947,0.06041905,-0.08606644,-0.0035400055,0.013868802,0.09403117,-0.027820162,0.008952039,0.048950735,0.023369238,-0.000346032,0.06134831,-0.04084427,0.048084125,-0.05367324,-0.05775421,0.037081297,-0.02306652,-0.0003885969,0.0033667164,0.11034039,-0.0025225703,0.05085229,-0.051625747,-0.06600341,0.058324844,0.05361623,0.08684639,-0.028647434,-0.07861418,0.02219873,-0.008535703,0.0277026,-0.021762786,0.08648988,-0.025111025,-0.027806377,0.02558651,0.020093534,0.007988148,-0.060889315,-0.038571205,-6.7185654e-05,0.026324319,-0.043050393,0.008359758,-0.0053694886,-0.00081308745,-0.042940862,0.0020226317,0.025477221,0.01442734,-0.06447713,0.018395562,-0.049826793,0.024614051,0.055639237,0.058653783,-0.021911977,0.048814423,-0.0072293505,-0.04576633,-0.098459624,-0.03457795,0.05803379,-0.022606032,-0.009721397,0.02520061,-0.0021682961,-0.00803911,0.032849398,0.047142804,-0.04648452,0.0037437214,-0.0520706,-0.047342513,-0.0037860828,-0.002127107,-0.029743385,-0.025070032,0.006029263,0.059147727,-0.041480754,-0.01539867,0.021993978,0.058464367,-0.006357476,-1.4310196e-33,0.05607928,-0.09582749,0.07719376,-0.040332507,-0.037873227,0.04669826,0.04973747,-0.04401285,0.07100135,-0.043923173,0.019991342,0.026954612,-0.08313475,-0.12107718,-0.04048747,0.053102873,0.010966392,0.062331226,-0.05393675,-0.016234351,0.050188024,0.1059101,0.022958303,0.0591538,0.0136779705,-0.08094717,0.07744449,-0.017756483,0.012125944,0.05485991,0.058429793,-0.060553722,0.009012311,-0.07387332,-0.07266644,0.089686565,-0.09138342,0.025300326,0.00033842135,0.0015439689,-0.024695981,0.01783314,-0.016949365,0.013587249,0.11886186,0.07883711,-0.12825063,-0.0012126608,0.041444972,0.054397862,-0.063360855,-0.054307457,0.0113776075,-0.0036739125,0.0025721872,0.016477542,0.05251243,0.034780174,-0.03654741,-0.04271683,-0.0070539853,0.023201838,0.07263515,-0.0933341,-0.009245718,0.016854707,-0.03128326,-0.025279205,0.020655192,-0.058313586,0.020070292,-0.00061449077,-0.0020217441,0.065473884,0.04612403,-0.065746516,-0.11824345,-0.03884489,-0.052343365,-0.057438508,0.14327665,0.08330894,-0.007829033,-0.021800725,0.08405673,-0.05938799,0.03440678,0.07262717,-0.0036142822,-0.002381416,-0.049437378,-0.009512434,-0.005355113,0.046336405,0.060538992,-2.581685e-08,0.0552193,0.030719575,0.036243394,-0.12921546,-0.082800806,0.044255294,0.03783797,0.018064765,0.0053663705,-0.06976656,-0.04376527,0.1125904,-0.054266807,0.027494866,0.020715222,-0.006356359,-0.001062039,-0.04813403,-0.03654213,-0.033908017,-0.044259034,-0.0034414614,-0.09190823,0.030421665,-0.03632074,-0.026010524,0.06515654,0.0032084922,-0.049600273,0.024526656,0.0755832,0.08814507,-0.030599887,0.040367313,-0.021590993,0.010400894,-0.0363118,0.008789927,-0.023076471,0.031014703,0.023503488,-0.0014703001,0.049948003,-0.03212813,-0.030163297,-0.010907162,-0.056143343,0.06120067,-0.050015472,0.11972383,0.00907848,-0.022482384,-0.1086173,-0.055431347,-0.02501347,-0.07650043,-0.0024119245,-0.022581888,0.008773164,-0.04359474,-0.014037109,-0.08148923,0.1657626,-0.056479782 +3.2.1.88,"The enzyme, which was characterized from dormant seeds of the plant Cajanus cajan (pigeon pea), has been shown to remove the terminal non-reducing beta-L-arabinopyranoside residue from the artificial substrate p-nitrophenyl-beta-L-arabinopyranose [1]. In the presence of methanol the enzyme demonstrates transglycosylase activity, transferring the arabinose moiety to methanol while retaining the anomeric configuration, generating 1-O-methyl-beta-L-arabinopyranose [2].",384,0.99999994,-0.07410326,-0.015624649,-0.02579107,0.042171028,0.027631847,0.08554872,-0.029261723,-0.019930528,0.12408446,0.042306975,0.03344346,0.081966735,-0.01526056,-0.021406496,-0.057780426,0.009957517,-0.016145784,0.03646262,0.029998422,-0.08304076,0.054605246,0.0060876287,-0.018754687,0.018143052,0.04173915,-0.089769825,-0.001386151,-0.02245061,-0.04787659,-0.021655545,-0.028402029,0.039348792,0.04986837,-0.030424317,0.009994499,0.13764215,0.008333522,-0.08309052,0.105039634,-0.011816889,0.11007532,-0.037277896,0.036100235,-0.009790178,-0.040570963,-0.026022075,-0.01990538,0.022379622,0.086030886,-0.06094401,-0.078322545,-0.061523993,0.02890631,-0.04809875,-0.047998056,0.010844125,0.04765086,0.043249603,-0.03827091,0.053628113,0.035389155,0.05151529,-0.037200764,-0.01199253,-0.10457109,-0.039571937,0.02194869,-0.09580907,0.08107996,0.046423405,0.003702533,-0.02918092,0.014930041,-0.054660216,0.0036748494,-0.03642426,-0.04356234,-0.06776471,-0.036911815,0.01913292,0.011887651,-0.043971237,0.03828207,-0.05255782,-0.0216402,0.00044377646,0.042989396,0.07387094,0.05531801,-0.039899964,0.05917826,0.004580988,0.004000252,0.026078999,0.0064236023,-0.049001925,0.052051377,-0.06557513,-0.036310144,-0.02084458,0.022294093,0.031110719,-0.002024688,-0.059917837,0.014607572,0.0803727,0.011736483,0.005412746,-0.00063859613,0.018271169,0.015496091,0.014925898,0.0533314,0.06675734,-0.098217614,0.07047201,-0.029453972,-0.045066886,-0.059797414,0.045131113,0.029318957,-0.052504323,0.030067956,0.015743496,-0.07984789,0.105131455,-0.07823971,6.6015643e-34,0.0053284895,0.05451453,-0.0030663228,-0.04352236,0.0183908,-0.053759277,-0.04639128,0.009000282,-0.024415921,-0.0313419,-0.026355036,-0.021565618,-0.028331898,0.10401742,-0.016842902,-0.0006781479,0.0076872376,-0.019534355,0.15108371,-0.009627165,-0.053543855,-0.00013220547,-0.11206554,-0.0076775285,0.039851587,0.047843955,-0.025302602,0.019956231,0.04527512,0.0040369905,-0.013533765,-0.030339194,-0.060385775,-0.02936324,0.030598924,-0.0017846194,-0.030767934,-0.03114818,0.0012132853,0.016915035,0.03223597,-0.0011341666,0.06286771,-0.020864066,0.025821326,0.027444677,-0.061672635,0.039369494,0.041967623,0.062866546,0.04746916,0.018691607,0.08358139,0.025046125,-0.035783246,0.027601227,-0.021138938,-0.025411224,-0.013302139,0.010537392,0.016417453,-0.05084764,0.01627868,-0.018440401,0.0010817781,-0.0022320957,-0.07018562,0.0018675262,-0.04296002,0.044009775,-0.051870152,-0.01343633,0.060949475,0.050009783,0.015579787,-0.0200373,0.0022107945,0.007096126,0.078141436,0.015804384,0.03962025,0.03186606,-0.026099913,-0.06565914,-0.048103474,0.055339355,0.04732913,0.06373688,-0.005030097,-0.0053609926,0.01817507,-0.021461446,-0.03436167,0.08825887,-0.0180306,-2.1943532e-33,0.06319045,-0.03875124,0.016662134,-0.09091054,-0.031173807,-0.06501302,0.068131216,-0.054585166,0.04890436,-0.036644965,0.013142517,-0.045528054,0.037999943,-0.068817064,-0.037158843,0.021155067,0.013747367,0.06644202,-0.11296235,-0.034580067,-0.078690864,0.09507374,0.06274773,-0.02563103,0.018752677,-0.048481625,0.026771646,0.10826266,-0.052549306,0.09667826,0.018985393,-0.018261345,-0.06966952,-0.05233457,-0.02898357,0.08157816,-0.09670007,-0.03204311,0.08375796,0.052150793,0.035590548,0.056377333,-0.0132911,0.00086448604,0.07052678,0.08187401,-0.03322971,-0.0027671226,-0.052588843,-0.15557861,-0.046689734,0.021815427,-0.012009645,0.032403376,0.042277984,0.076369464,-0.029247107,0.10103915,-0.024408834,-0.06004087,-0.0073075145,-0.024510588,0.042740885,-0.034782138,0.029528808,0.048578084,0.026513774,0.029127892,0.07494308,0.012041105,0.023956811,0.07188835,-0.0048788385,0.11834886,-0.033933837,0.007118085,-0.14461139,-0.06888717,-0.10833771,-0.06749605,0.022358907,-0.014760492,-0.05856731,-0.0829877,-0.012379602,-0.017174076,0.0003029167,0.067977086,0.030893931,0.007318582,-0.002568791,-0.029595258,-0.042514227,0.027733605,0.07962328,-4.1989736e-08,0.010890338,-0.028507182,0.052224737,-0.10268624,-0.042680994,0.019573808,0.038366124,0.023203498,0.030407164,-0.029301522,-0.09733774,-0.00042628267,-0.06934957,0.09228071,-0.077417575,0.009352305,-0.039447546,0.09208053,0.011511758,0.004684571,-0.10122763,0.04623239,-0.059881642,0.040376075,-0.03149975,-0.019767275,0.060631387,0.0074896,-0.024547208,0.03362634,0.003818988,0.03297411,-0.029350605,0.0051670983,-0.01872744,0.026363416,-0.036271933,0.023854531,-0.0038306937,0.0016328888,0.054250974,-0.06703859,-0.11428929,-0.002099162,-0.011088529,-0.062147837,0.031652775,0.041726395,-0.014928725,0.03272068,0.13629988,-0.0136337895,-0.06049967,-0.061962597,-0.03329979,-0.05959856,-0.032151934,0.039380733,-0.035170887,-0.04449352,0.010292738,-0.0004352535,0.14786157,-0.1146892 +3.2.1.89,"This enzyme, isolated from the bacterium Bacillus subtilis, hydrolyses the beta(1->4) bonds found in type I plant arabinogalactans, which are a component of the primary cell walls of dicots. The predominant product is a tetrasaccharide. cf. EC 3.2.1.181, galactan endo-beta-1,3-galactanase.",384,1.0,-0.014975978,-0.029758785,-0.10625066,-0.0053046853,0.056242846,-0.0018872976,-0.04222486,0.033358917,0.070819564,0.0016851891,0.07191705,-0.07451939,-0.015580329,0.018629497,-0.10032799,-0.011754985,-0.007391025,0.025497673,0.026516005,-0.017002318,0.045880686,0.10346967,-0.032503527,0.051637948,0.07056937,-0.003324257,0.046695706,-0.025573865,-0.011647047,-0.09152617,-0.00984468,-0.021045137,0.108630374,-0.0015451689,0.012333708,0.14966588,-0.03798511,-0.078010865,0.11993122,-0.03148487,0.023421193,-0.024465285,0.059035048,-0.032913182,0.007407336,-0.0026274058,-0.03240862,0.062132027,0.10776003,-0.056006916,-0.01276273,-0.06771098,-0.033651885,0.07556607,0.06319799,-0.018536326,0.014028109,-0.016839495,-0.016451238,0.07481486,0.12331363,0.03919586,0.0033054906,-0.015691657,-0.07268637,-0.011202102,-0.0036966214,-0.03461468,-0.017955704,-0.046401262,-0.045879077,0.009994236,-0.037930697,-0.014556958,0.0055466425,0.034692075,-0.0547831,-0.018296134,0.015134559,-0.02761114,0.047873564,-0.0091876555,0.022088753,0.045961834,-0.0028520508,-0.092662014,0.020250224,0.07710243,0.044738587,0.018299116,0.03340924,0.051009666,-0.016044194,-0.035701673,-0.06429012,0.006480712,-0.012007772,-0.022432128,0.058592267,-0.012284948,-0.018447317,-0.048566308,0.029639052,-0.06574304,-0.06131322,0.061062146,0.03561005,0.027587852,0.07884028,0.01696644,-0.03893994,-0.027248623,-0.019028392,-0.03188718,-0.050953735,0.01348379,0.028797274,-0.06962213,-0.012183351,-0.009046452,0.04391145,-0.023234734,0.06774354,0.014061635,-0.02190173,0.02482728,-0.079654366,1.797256e-34,0.037006438,0.012891167,-0.025448356,0.01879923,0.023138592,-0.0006796207,-0.035793252,-0.029530812,-0.029903384,-0.05389027,-0.114095025,-0.032590464,-0.01764486,0.09487783,0.006875223,0.015805949,0.012942724,-0.05545551,0.050343677,0.03195991,-0.058051236,0.06891905,-0.064191006,-0.05112194,0.09753055,0.0013747455,0.042710554,-0.037805114,0.07119945,0.011743454,0.07474761,-0.07063552,-0.090349615,0.012166685,0.07891081,0.06361079,-0.070268944,0.012909889,-0.046766598,-0.0076213228,0.045681756,0.052551556,0.026479756,-0.029872695,0.028971268,-0.017066816,0.011500552,0.05496391,0.053034976,0.041253068,0.047618423,0.0037899294,0.020242952,-0.06374451,-0.038221914,0.041030593,-0.021878764,0.07593414,0.0061598583,0.08246532,-0.06394594,0.06323414,-0.06469102,0.05538297,-0.058565233,0.068242975,-0.09022909,-0.008366678,0.001452037,-0.021950616,-0.07952913,-0.019227562,0.033915214,-0.010078875,-0.07723052,0.007791581,-0.0028133846,-0.020270213,-0.0077961218,-0.021490386,-0.0053528813,-0.007474527,0.017362932,-0.041393984,-0.07145812,0.10108399,-0.005411807,-0.009818933,-0.013773336,0.052929144,0.024744045,-0.03549328,-0.061772484,0.06642602,0.050996315,-1.3292816e-33,0.092372805,-0.09462138,0.08387048,-0.10583918,-0.051747065,0.07446037,-0.0050040386,-0.015693001,0.038969982,0.040514044,0.048957165,0.022093158,0.008414216,-0.0577251,0.015743636,0.021453962,0.044600263,0.09128504,-0.032294415,-0.04546926,-0.028408112,0.10715783,0.048872944,-0.06066411,-0.00637573,0.0010831201,-0.029392958,0.12288561,0.01555985,-0.0112578515,-0.025307974,-0.030784039,-0.02849654,-0.04962106,-0.09375225,0.01626921,-0.087587625,-0.077819884,0.059547782,0.016879054,-0.009419158,0.080711216,0.010472069,0.01984121,0.0342747,0.10965435,-0.00832873,0.026645584,-0.010978374,-0.035131592,-0.03168178,-0.046318013,0.014461439,0.0131484335,0.04524166,0.016403956,-0.005590213,0.11751274,-0.0029240504,-0.08153522,0.021049626,-0.040279847,0.064400606,-0.06555501,0.06453538,0.036060937,-0.02184578,0.017921112,0.025426105,0.002597895,0.053311974,0.03745736,-0.05436106,0.03605238,-0.024844943,0.03794068,-0.1345733,-0.09232979,-0.03376355,-0.010525256,0.048597816,0.021425026,-0.04569946,-0.085273504,0.059737705,-0.078517556,0.056044683,0.12271853,0.0012431571,0.03915707,-0.035304695,0.035956487,-0.0387194,0.04419937,0.10832918,-3.7386272e-08,-0.00017437214,-0.06877657,0.0029886065,-0.122228034,-0.022047162,-0.0013192479,0.055993956,0.028124318,0.03395751,-0.05457453,-0.030082775,0.063783035,-0.062328458,0.051350422,-0.022487763,0.04399404,-0.016927646,-0.046654016,0.007816382,0.017250607,-0.040006384,-0.025490314,-0.08088652,0.01618185,-0.045669343,-0.073727444,0.011479803,0.010272714,-0.04853849,-0.012856924,0.042727135,0.06946013,-0.045820124,-0.09769751,-0.073441364,0.069495834,-0.07062698,0.027533442,0.004732773,0.03591524,0.05637396,-0.056705575,-0.03775636,-0.020083407,-0.07445588,-0.016345108,-0.014628098,0.08352441,-0.032483783,-0.010946734,0.067264065,-0.044565503,-0.06347851,-0.049596682,-0.065037265,-0.04580644,0.024036944,-0.017465312,0.009183981,-0.041411478,-0.020158507,-0.028716464,0.14630572,-0.013708377 +3.2.1.94,"Optimum activity is on those 1,6-alpha-D-glucans containing 6, 7 and 8 glucose units; those containing 3, 4 and 5 glucose units are hydrolysed at slower rates.",384,1.0,0.003409862,-0.07418505,-0.02437176,-0.031074341,-0.06546306,-0.060151294,-0.010865379,0.066210374,0.027991274,0.04075918,-0.076490015,0.12030667,-0.061309498,0.012926574,-0.043863967,-0.032125454,0.028952738,0.023942998,-0.09344109,-0.043277867,0.081594326,-0.086267434,0.053787895,-0.0020426784,0.019505424,-0.028327256,0.03833589,-0.032400105,0.01591404,-0.04389814,-0.027507735,-0.034607116,0.10086106,0.00052980933,-0.021455718,0.12258114,-0.058385957,-0.03804261,-0.058235977,0.037584428,0.004707443,-0.06946938,0.049696542,-0.0037037658,-0.05610964,-0.038037088,-0.08820251,0.035879068,0.033640638,0.02859994,0.04239711,-0.057548564,-0.09292025,0.030686855,0.052275505,-0.030705573,-0.12545246,-0.01329822,0.03436947,0.007069587,0.023226468,0.04121796,-0.032142892,-0.02809038,-0.020296635,-0.057551537,0.018704396,-0.0687815,-0.09650866,0.08647963,-0.011137189,0.03780818,0.009733055,-0.022814557,-0.0094897775,-0.0049129874,-0.032312848,-0.05855675,0.029782845,-0.037535053,0.123173565,0.029032052,0.07639708,0.1193367,-0.049369313,-0.01817038,-0.02938342,0.011954362,0.047971915,-0.015012338,0.038611863,0.032398794,-0.07050528,0.003565575,-0.0047311215,0.04463355,0.0044461987,-0.0648605,0.051338684,-0.010948062,0.03681208,-0.010697551,0.066280656,0.029463498,-0.053061545,-0.035567287,-0.0052346927,0.114588656,0.040254246,0.04295165,-0.013518786,0.040921394,-0.03858002,0.04789543,-0.1065147,0.042555355,0.06767125,-0.030194143,-0.035887644,0.030756548,-0.02273095,-0.01047222,0.11420886,-0.015974475,-0.056898303,0.08250648,0.028477924,1.8633415e-34,0.005653958,-0.08783588,-0.016267896,-0.039496556,-0.10161644,0.03852403,-0.07599389,-0.03186875,0.06380935,0.015141159,-0.11142655,0.031483285,-0.028260158,0.1404426,0.043065906,-0.008570941,0.036253422,-0.013379284,0.012884261,-0.024135605,0.025792453,0.015021036,-0.0041618766,0.011777922,0.07052021,0.012066672,-0.025894184,0.022222547,-0.017922083,-0.023049003,0.005709445,-0.018072613,-0.015051902,0.033530362,0.015762411,0.099324696,-0.02949005,0.051559646,0.07032758,0.011005181,0.06643088,0.052203402,0.09558915,-0.06398039,0.057034645,0.0785266,0.020253185,0.016311012,-0.022946987,0.058791593,0.06609681,0.0860038,-0.026361233,-0.0029048824,-0.0044642645,0.013034717,0.0049325014,0.0013978118,0.017779889,0.10191937,0.0035198305,0.043363817,0.015873158,-0.013071917,-0.03247861,-0.0037330051,-0.075092494,-0.015726333,-0.030140037,0.040823016,-0.04886062,-0.035311963,0.100321986,-0.05980574,0.020973902,-0.032459203,0.10435907,0.061382096,-0.055452902,-0.032568935,0.041152235,0.03457139,-0.04222764,0.024463667,-0.098685674,0.08233702,-0.078356355,-0.050868876,-0.045110937,0.04206466,-0.044135664,0.021160403,-0.081489556,0.03234378,-0.026573554,-2.6715772e-33,0.069011554,-0.07710864,0.066725045,0.062000014,0.04256488,0.06694375,0.05392148,-0.1041812,0.005041645,0.0041228975,0.036794618,0.08018076,-0.07678254,-0.017418582,0.0052441778,0.055479523,-0.11078525,0.0425477,0.012611669,-0.0131532,-0.08057814,0.12304241,-0.0021621163,0.004118635,0.1067625,-0.029240029,0.050114688,-0.029215911,0.027808413,-0.011268653,-0.01668599,-0.041922644,-0.00095019344,0.008354009,-0.02648402,0.043618802,-0.008875278,0.011553572,-0.052184414,0.026836818,0.049620863,0.050870944,0.04538331,-0.031504605,0.05243893,0.02956535,-0.031606592,-0.039205506,-0.08601152,0.050415996,0.014212294,-0.07308945,-0.08095476,0.009774937,0.07103655,0.005988121,0.0047397856,-0.007779777,-0.023352265,-0.028648114,-0.051546495,0.012015946,-0.026796665,-0.07665414,-0.018947052,0.022660049,0.024651967,0.030770674,0.018989218,0.07616553,-0.018766819,-0.060762446,0.032915417,-0.045238856,-0.0041564777,-0.043377813,-0.0115660485,-0.02583044,-0.009379995,-0.04308824,-0.06511437,0.08828609,-0.018119168,-0.022499617,-0.01690602,-0.009144372,0.064235784,0.045698848,0.032159492,0.1069039,-0.017022299,-0.04540258,0.058745354,-0.036988717,0.012660142,-3.4370725e-08,0.039071087,-0.036234107,-0.04564509,-0.009025543,-0.014084704,-0.032163557,-0.023335896,0.11198475,0.026366983,-0.01659474,0.04648409,0.10780629,-0.0117555065,0.020836378,-0.043107655,-0.037448872,-0.063452356,0.019484214,-0.050725687,-0.024172934,-0.09449644,0.024162035,-0.07607481,0.007515493,0.0031346707,-0.1123696,0.04348194,-0.007377823,-0.02621922,0.009992587,0.0018751639,0.06259119,-0.04872417,-0.043878302,-0.012176471,0.021767177,-0.045159634,0.036028348,-0.030997317,0.04187921,-0.025100293,-0.11513241,0.0020407152,-0.025469417,-0.07863576,-0.03525618,-0.10415541,-0.013498356,0.013359759,0.091379285,-0.012091708,0.014557541,-0.06827796,-0.036807567,0.014680659,-0.043889295,-0.04983791,-0.06145598,-0.04292251,-0.09877883,-0.0023661382,0.021856632,0.024528716,-0.05622622 +3.2.1.96,A group of related enzymes.,384,1.0,-0.058240786,-0.08094481,-0.101347364,0.0055625383,0.017761093,0.031428788,-0.031825274,0.0064744307,0.02660647,-0.06639858,0.06857076,-0.03868146,-0.04493052,0.06187619,-0.08148325,0.036746025,-0.12672392,-0.008876677,-0.06312753,-0.108845316,-0.014908816,0.040581487,0.017820815,0.0049560782,0.011312911,0.021795908,0.042051923,-0.055478238,-0.012840116,-0.046618927,-0.040195297,-0.036589034,0.063449666,-0.010244099,0.04595976,0.10844069,-0.022501606,-0.029151147,0.011014372,-0.007220872,0.040993694,-0.0024353012,-0.01567117,-0.033413924,-0.07358836,-0.008513575,-0.005636474,0.016957475,0.013012513,0.05863037,-0.05192964,-0.14138727,-0.045823645,0.03316644,0.019588301,0.025657218,-0.042930502,-0.05562877,-0.07372181,-0.007810601,0.06354211,-0.042854864,0.024523022,0.052352183,0.0011102952,-0.0099584125,0.08560865,0.00971347,-0.014696438,-0.07445529,-0.022531383,-0.12290294,-0.055785082,0.023577103,-0.023296947,0.015737133,-0.020196108,-0.029264033,0.0047738305,-0.080927685,0.03179848,0.0014025581,-0.0008882365,0.08541361,0.004364504,-0.03159374,0.04611049,0.012659167,0.025308164,-0.006731136,-0.0036286705,-0.020460064,0.005662979,-0.02942329,0.0017291321,0.0071719647,0.043270014,-0.008337295,0.01620123,0.011839101,-0.010716793,0.009779036,0.009671972,-0.080875136,-0.076512955,0.016520116,-0.06793784,0.04262931,0.051680986,0.0035726696,-0.006852907,0.027076622,0.03506396,0.012146036,-0.004758804,0.024009539,0.051646575,-0.031209247,0.011356049,0.02883431,0.038575567,0.02453144,0.12205469,0.07363327,0.042748634,0.05671236,-0.16420537,-8.005531e-33,0.05569086,0.017266145,-0.020183606,-0.044402946,0.03563902,-0.0060788137,-0.042638086,0.08973811,-0.097343326,-0.019090882,-0.099930026,-0.050397947,0.056228746,-0.036454987,0.02203845,0.0037614868,0.0040367483,0.007860952,0.020443784,-0.015116291,-0.094536886,0.11446733,-0.09223007,0.0528422,-0.009249811,0.042038936,-0.03201229,0.001501441,0.021419005,-0.01955387,0.05233765,-0.06541243,-0.08249516,0.02037179,0.027150478,0.06941717,0.009670706,-0.053100172,0.017478038,0.04707463,0.0033871038,0.01832171,0.028723605,-0.08319973,0.078974284,-0.061273545,-0.07301522,0.029450128,0.02687969,0.04277161,-0.009460368,-0.06748369,0.08267405,-0.023972172,-0.049083386,0.026769878,-0.054806788,0.1194874,0.051812477,0.081770025,-0.0022183636,0.07956648,-0.07193015,0.055407856,-0.0025116096,0.0067404527,-0.035693716,-0.013986928,0.011136476,0.14157794,-0.07596459,-0.015341725,0.032700997,0.012350133,0.035135686,-0.03246419,-0.031234508,-0.0003063755,-0.06078191,0.057909824,-0.045741692,-0.048637774,0.036484014,-0.05202201,-0.09487622,-0.025637405,-0.055514414,-0.046237584,-0.03678082,0.040762737,-0.030900745,-0.003297864,-0.05626377,0.058581408,-0.010280341,3.456172e-33,0.11846181,-0.0988563,0.047990292,-0.07891684,-0.0010979837,0.063105084,0.055415474,-0.04491464,-0.015534425,0.06338798,0.046780195,-0.0039650355,0.020176802,-0.052220225,0.05717417,0.045806553,-0.0013586918,0.12136993,0.07423274,-0.006455522,-0.029087055,0.10480433,0.035904553,0.034149304,0.050970256,0.020796243,0.007371194,0.09240236,0.009364062,0.03679955,-0.020781338,-0.032973263,-0.03181668,-0.03965096,-0.033744156,0.056645077,-0.029468955,-0.014008397,0.031579852,0.0070777363,0.011647696,0.08020448,0.053279325,0.119393505,0.03290973,0.010207,0.0116745215,0.019468065,-0.057822186,-0.04246987,-0.009143444,0.006902426,0.036888108,0.004442982,0.016485453,0.049664713,0.04268598,0.0032899557,-0.074657656,-0.042451907,0.010376615,-0.05946948,0.059164148,0.023949672,0.0116860205,0.005943758,-0.058212765,-0.028226625,0.04472529,0.008424027,0.04658898,-0.06264173,-0.016964937,0.046475753,-0.0013102716,-0.02793488,-0.12183548,-0.026493931,-0.009994258,-0.03799091,-0.014896767,0.024137845,0.013047545,0.00238394,-0.04733455,-0.08236505,0.03955825,0.14361234,0.06563789,0.026687229,-0.012209535,0.005534716,-0.055063047,0.019840226,0.03973883,-1.7436115e-08,0.112746425,-0.09164,0.03646003,-0.056119677,0.041312058,-0.011399143,-0.03292924,0.023542246,0.007025384,0.06523109,-0.017449446,0.06855809,-0.02725228,0.045522165,0.022141846,0.03774376,-0.06430857,-0.009739945,-0.030729502,0.022263864,-0.04671006,-0.010028618,-0.08001822,0.045071393,-0.018613532,-0.062311597,0.0269657,0.026185395,-0.0037537408,-0.037706308,-0.030191785,0.023238026,-0.020743929,-0.083340384,-0.08988727,-0.024140663,-0.02410435,-0.049513433,-7.700849e-05,0.05354229,-0.00016641978,-0.08080434,-0.032760438,0.021946317,0.02051691,-0.026660725,0.0364759,-0.051269736,0.02787833,-0.018179934,0.018475955,-0.0028870662,-0.025133295,0.0051573846,-0.08965918,0.004291533,-0.0045556463,-0.072734006,0.01466533,-0.06792746,0.03452724,0.037155982,0.23371463,-0.040806666 +3.2.1.97,"The enzyme catalyses the liberation of Gal-(1->3)-beta-GalNAc alpha-linked to serine or threonine residues of mucin-type glycoproteins. EngBF from the bacterium Bifidobacterium longum specifically acts on core 1-type O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc. The enzymes from the bacteria Clostridium perfringens, Enterococcus faecalis, Propionibacterium acnes and Alcaligenes faecalis show broader specificity (e.g. they can also release the core 2 trisaccharide Gal-(1->3)-beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc-(1->3)-beta-GalNAc) [1,2]. The enzyme may play an important role in the degradation and utilization of mucins having core 1 O-glycan.",384,1.0,-0.029200803,-0.13195354,-0.049262993,-0.029088583,0.08456739,-0.011475874,-0.048936363,0.04981505,0.08625721,0.0021142333,0.017778354,0.03678979,0.023055345,0.038949322,-0.052157804,0.017402057,-0.008036756,-0.0032723665,0.042048942,0.0757363,0.13151847,-0.017629927,-0.07218541,0.048482276,0.042074356,-0.029331848,0.006916175,0.016794119,-0.031574834,-0.106498204,0.005281157,-0.05742988,0.08254087,0.021873271,0.0008536389,0.08275917,-0.027108634,0.0027134249,0.10098118,-0.013574012,-0.0012746293,-0.011436422,0.01307357,-0.033371825,0.0072493935,-0.022052478,0.0040840064,0.029294144,0.06123284,0.017870164,-0.045871653,-0.05034578,-0.0646127,0.10072893,0.113974005,-0.019201187,-0.062498394,-0.022100281,0.042809032,0.06951032,-0.0064442176,0.002198666,0.05986604,-0.058385868,-0.04221931,-0.10960188,0.025399443,-0.074516736,-0.019833429,-0.032445606,-0.0758926,-0.033287987,-0.016203841,-0.045259107,0.06712381,0.11467968,-0.06143553,-0.032194015,-0.03546716,-0.04256407,-0.0069142636,0.008912935,0.011771628,0.049844217,-0.034874707,-0.019934874,0.06580158,-0.008914737,0.06199856,0.004373046,0.033462085,0.028772216,0.012828837,-0.043346327,0.039880175,-0.03430728,-0.020233285,0.0054468783,0.022337658,-0.046554457,-0.016011707,0.01617781,0.03689506,-0.09435651,-0.09880896,-0.0038751608,0.058702596,0.07697925,0.06010072,-0.03270714,-0.02031744,0.045207992,0.0041711656,0.0016782766,-0.08492663,0.06635007,0.06066421,-0.06831587,-0.06381294,0.013389934,-0.021107689,-0.016654026,0.05478654,0.021989623,-0.06723233,0.09606034,-0.019021282,2.9153599e-33,0.024281595,0.06748784,0.00939152,-0.020024,-0.028378943,-0.011224192,-0.09555073,-0.023678731,-0.015331174,-0.04104103,-0.029347869,-0.006710191,-0.016261648,0.0348754,-0.0050087683,-0.0030591215,0.06619465,-0.0069234073,0.004304448,0.00017649554,0.025912786,0.028909277,-0.019000253,-0.0103757605,0.14143531,0.033358686,0.032030087,0.04089379,0.008796922,-0.025985055,0.053954482,-0.03708781,-0.06480175,-0.0067772,0.07197426,-0.0132391425,-0.06371817,0.0006874374,0.025833985,-0.017453462,0.0019745259,0.017734531,0.0026321318,0.018449139,0.026546331,-0.022314178,-0.037584424,0.10375158,-0.020710718,0.049733378,0.06835286,-0.050620373,0.004309269,-0.018576834,-0.11141551,0.052473098,-0.024900159,-0.01618889,0.05935802,0.047089607,0.013408456,0.017407043,-0.021732045,-0.029513936,-0.002939149,0.015742347,-0.14004007,0.06424375,0.011491612,0.045084182,-0.07427795,-0.024496539,0.022237051,0.028170777,-0.01659393,-0.028270548,-0.05858367,-0.042545658,0.045567416,-0.0329092,-0.0048433384,0.054266643,0.045293,-0.0027576054,-0.05658676,0.031244794,-0.089578584,-0.0601346,-0.0259357,0.04914082,0.04567564,-0.02205561,-0.057118863,0.042158812,-0.08083665,-3.2200978e-33,0.12695488,-0.16980736,0.08179872,-0.013609482,0.042562596,0.05920631,-0.03178997,-0.044210717,0.010290058,-0.06779619,0.034187887,-0.0026407172,-0.01901605,-0.08393632,0.021402294,-0.008937471,0.0068819094,0.081913725,-0.09446912,0.009920201,0.0068874625,0.016920153,0.026270041,-0.06939729,-0.026688125,0.07560008,0.016785074,0.038737807,0.053287745,0.10361273,-0.029207801,0.051667858,-0.06365928,-0.051521447,-0.07651134,0.01785558,-0.029379928,-0.016161751,0.053425103,-0.020817876,0.010365811,0.03147375,-0.0022895618,-0.027775919,0.027708078,0.05576543,0.049241383,0.013993579,0.013932908,-0.011645982,0.02005564,-0.03677169,0.02335602,0.021105615,0.01403021,0.035574015,0.014740219,0.0062588146,-0.0024605836,-0.07111488,-0.05776467,-0.02791455,0.040165603,-0.01274455,0.03877132,0.021430934,0.004353493,0.007974348,0.033464197,-0.06102209,0.010232553,0.00060884893,-0.036592484,-0.0140033895,0.0021848688,0.084970154,-0.1397362,-0.056059495,-0.0020266708,0.028713439,-0.022854047,0.032185152,-0.08335314,-0.040758666,0.055379678,-0.06377016,0.049083877,0.10436294,0.0057225116,0.016900366,-0.07886487,0.002053039,0.026668042,0.046438698,0.072123185,-4.7304347e-08,0.049239058,-0.034381457,0.012376335,-0.0062870206,-0.021310696,0.022901954,-0.045774616,0.046255775,0.013951563,0.004348434,-0.0020160545,0.07570808,-0.010769022,-0.060641617,0.013968632,0.03571964,-0.036693234,-0.013147364,0.00416821,0.03525325,-0.09724406,-0.014695117,-0.09817084,0.07889278,-0.0011108235,-0.07590651,0.0024735536,0.045808498,-0.07937455,0.028264912,0.07195003,0.061009225,-0.04849638,-0.06540914,-0.06428373,-0.046085525,-0.054246336,0.037002776,0.042380974,0.08062193,0.11331959,0.048654374,-0.10055651,-0.029160267,-0.050639436,0.022207217,-0.040531497,0.042723615,-0.08507466,0.07210491,0.062033936,0.0036467167,-0.04752841,0.011066027,-0.07640794,0.0036519032,0.037757188,-0.08481581,0.017784728,-0.062344912,-0.040427536,-0.055786442,0.20079087,-0.018450538 +3.2.1.98,"cf. EC 3.2.1.3 glucan 1,4-alpha-glucosidase, which removes successive glucose residues; EC 3.2.1.2 beta-amylase, which removes successive maltose residues; EC 3.2.1.116 glucan 1,4-alpha-maltotriohydrolase, which removes successive maltotriose units and EC 3.2.1.60 glucan 1,4-alpha-maltotetraohydrolase, which removes successive maltotetraose residues. The products have the alpha-configuration.",384,0.99999994,0.006140577,-0.042607173,-0.06872615,-0.011555485,0.046448324,-0.0170026,0.0076498883,0.016316263,0.06910533,-0.078240976,0.017435623,0.04731326,-0.09247789,-0.02425301,-0.07340343,-0.07714145,-0.050000153,-0.014141609,0.008110964,-0.06861742,0.11036006,-0.00807633,0.0046223174,0.040539395,0.062285107,0.030837307,-0.027606066,-0.02772703,0.0086902855,-0.09476747,-0.03981813,-0.07429066,0.113097474,-0.0013186549,0.02524541,0.035247635,-0.05071548,-0.054004308,-0.07572911,0.025289375,0.037138633,-0.032726444,0.026041325,0.021150675,-0.066899285,-0.008862755,-0.13218614,0.007211152,0.012893453,0.021559846,-0.039908797,-0.07073428,-0.11137885,0.07628869,0.08021318,-0.04776309,-0.038677897,0.008868168,-0.02913205,0.07368681,0.033928465,0.090288796,-0.08222165,-0.03443058,0.0012899194,-0.068110965,0.0746731,-0.13658868,-0.027048206,0.020332823,-0.105594605,-0.057148505,0.011625424,0.041610252,0.02365595,0.05748477,-0.042535726,-0.033047993,0.015190471,-0.002188151,0.06296562,-0.028741335,0.034170005,0.10067228,-0.078018256,-0.035315733,-0.051315606,-0.036172237,0.051131148,0.014890676,0.053531416,-0.031128371,0.029692594,0.007114072,0.021789799,0.07093026,0.022789167,-0.035333104,0.07035753,-0.017103242,-0.017972155,0.01906205,0.02780769,-0.026003003,-0.11406881,0.080112696,-0.019086296,0.055746756,0.06853506,-0.011451152,-0.014030156,0.004517401,0.021096956,-0.032884862,-0.08881455,0.06190949,0.059040643,-0.045214936,0.043054048,0.041480616,0.011206613,0.008788562,0.12213823,0.0033699533,-0.025899608,0.080931194,-0.05171026,2.3005264e-33,0.052420165,-0.0066248896,-0.023690175,-0.023267044,-0.04320522,0.036345914,-0.09079251,0.009527078,0.00269982,0.053789094,-0.046259075,-0.008036287,-0.025508458,0.052344263,0.02999182,-0.0346301,0.059804354,-0.028521279,0.028457131,0.012296384,0.011706734,0.07038417,-0.012081713,0.002307535,0.10204755,0.04494921,-0.06265447,0.019254027,0.018796584,-0.003297288,0.02909298,0.0036677679,-0.12945527,0.058018126,-0.0037926156,0.060794234,-0.05416436,-0.028601788,0.03890056,0.061444204,0.047093257,0.031800587,0.052169476,-0.084346294,0.07102339,-0.029219743,-0.035808943,0.12314424,0.043900017,0.06494092,0.04415777,0.037398066,0.026565108,0.02326627,-0.009090309,0.04717076,-0.013521886,0.024634639,0.025394995,0.02323283,-0.0013916283,0.086939156,-0.015668057,-0.049866047,0.0089862095,0.02403387,-0.066400066,-0.026525488,-0.0787259,0.036415372,-0.098920874,-0.012379572,0.0822325,-0.023828225,0.022203391,-0.063869946,-0.0659809,0.049245354,-0.053447463,-0.028236309,-0.0011235343,0.060208246,0.037778955,0.043753162,-0.088717096,0.04346948,-0.016915983,0.021328397,-0.03172739,-0.005823477,-0.018264895,0.0072047855,-0.015909031,0.063822806,-0.046890806,-3.1179848e-33,0.119666174,-0.12471656,0.06005801,-0.04265749,-0.008974997,0.03267313,0.04766849,-0.07499327,0.023173764,-0.010717208,0.08543746,0.036449485,0.005886557,-0.109928064,0.022046188,0.015847621,-0.081498526,0.0132960025,-0.04449578,0.004680909,0.016701983,0.14113955,-0.016073806,0.013602126,0.028155427,-0.09316839,0.054497607,0.047710624,0.008490497,-0.015688496,-0.008358562,-0.049565088,0.050290026,-0.052701954,-0.049334865,-0.012707723,-0.023529513,-0.0075076846,-0.010416742,0.01986234,0.041535012,0.087523006,0.008715085,0.040954564,0.10150302,0.10080854,-0.014459049,0.010197345,-0.003802038,-0.0018388415,-0.027034473,-0.03404868,-0.09090437,0.005355822,0.032572057,0.03755176,0.067263156,0.008564513,-0.021985974,0.0020974039,-0.060127325,0.055438142,0.075945154,-0.037782617,0.06708434,0.043118875,-0.038899105,0.059005357,0.05786863,0.0632646,0.0030228533,-0.058845848,0.02075691,-0.0014395411,0.01801896,-0.01289028,-0.07861859,-0.0153783765,-0.030444266,-0.07776431,0.040971905,0.025576852,0.007298733,-0.0037536535,0.0051229117,-0.02311483,0.02038725,0.050734825,-0.02214811,0.021125311,-0.03465912,-0.01356758,0.04063401,0.042883124,0.092092924,-4.1317957e-08,0.080585204,-0.016794907,-0.03737483,-0.00026295238,0.016359014,-0.0041933083,-0.042060304,0.09923702,0.010551822,-0.052457586,-0.054001573,0.07423369,-0.04626962,0.030437492,0.016268292,-0.04211793,-0.029419864,0.02140689,-0.020404218,0.0021297543,-0.12678516,0.019442556,-0.06756214,-0.029682146,-0.0052344883,-0.114238,0.031344328,0.029011639,-0.049335655,0.035843354,-0.012049779,0.07347641,0.030544844,-0.0653512,-0.027572237,-0.01832865,-0.084226474,-0.030863795,-0.012853789,0.04216358,0.061767705,-0.0423801,-0.034104783,-0.036115587,-0.054310493,-0.02467387,0.022454437,-0.06311494,0.016099637,0.02300158,0.0063497634,0.013660496,-0.056366593,-0.030468304,0.022983741,-0.029571928,-0.012087397,-0.059450217,0.022067046,-0.085001774,0.02788495,-0.031259324,0.15537311,-0.022629868 +3.2.1.99,"Acts best on linear 1,5-alpha-L-arabinan. Also acts on branched arabinan, but more slowly.",384,0.99999994,-0.016757576,-0.13634224,0.022508314,-0.0574895,-0.007280434,0.1027779,-0.0026984825,-0.052420076,0.040952627,0.04343926,0.09394877,0.0145357,-0.11118946,0.075215265,-0.009403047,0.065678865,-0.038640324,0.035372224,-0.0391741,0.009065037,0.030780777,-0.07567567,0.024193555,0.03503579,0.05859362,-0.036239687,-0.043575782,0.00030462624,0.059440915,-0.1780142,0.009091081,0.06367123,0.04631971,0.008403926,-0.07172176,0.114457734,-0.07471406,-0.0646662,0.036584686,0.02318545,0.12847884,-0.022120513,0.10019438,-0.019589318,0.021455364,-0.05489374,0.017298372,0.008345816,0.03312698,0.01825092,-0.040525056,-0.11074158,-0.018984895,0.06001147,-0.06493939,-0.017390171,-0.08165581,0.00013002398,0.054708056,-0.019066477,-0.01765285,0.02837388,-0.0026458513,-0.009798734,-0.047094975,0.072466075,0.044860546,-0.04954419,-0.0462345,0.016158668,-0.04128096,-0.030742973,-0.108341806,0.008532725,-0.05078874,-0.031957407,-0.03065816,-0.10466599,-0.06404256,-0.021963803,-0.030820468,-0.04142897,-0.07936953,-0.0061932695,-0.013944944,-0.018599002,-0.021457745,-0.009603494,0.0348128,-0.0018524107,0.049284928,0.086979404,0.050643764,0.014082282,0.019373396,0.04370862,0.017616004,0.016782971,-0.0025611494,0.03852027,0.022768969,-0.011182403,-0.02814831,0.005342391,-0.055897653,-0.014887223,-0.00584163,-0.04678299,-0.1176294,-0.033789117,-0.054212708,-0.08070093,-0.013041015,-0.029045954,-0.011016061,0.0081083905,0.03697977,-0.027848575,0.014801917,-0.019477412,0.01825433,-0.0035537768,0.101975776,0.05469526,-0.061156534,0.06891185,-0.09614128,7.4760366e-34,0.051203102,-0.01967935,-0.005619113,-0.011469331,-0.039796717,-0.032040928,-0.024538957,-0.00643062,-0.059967615,-0.076,-0.028525382,-0.017382847,0.04063346,0.034500338,0.049585123,-0.05852015,0.069221325,-0.04007889,-0.020380592,0.008037333,0.005432114,0.12739433,-0.05276427,-0.056561682,0.047965284,-0.044103883,0.033196334,-0.0204162,-0.027301239,0.018036975,-0.011698537,-0.014176283,-0.091333315,0.0610593,0.05016477,0.055581246,-0.10185648,-0.010742981,-0.0118112285,-0.08823663,0.007943895,0.02885296,-0.003509417,0.0037393277,0.09140475,0.024123779,0.025358256,0.091835834,-0.030497879,0.031900242,0.08272538,0.037972294,0.021867018,0.008494385,0.021647688,0.03964484,0.03728023,0.07413886,-0.06804251,0.14350809,0.017340412,0.0166059,-0.009368894,-0.03616903,-0.080848545,0.07194714,-0.060507253,-0.053659696,0.06807441,-0.02408922,-0.02224028,0.023268182,0.06274473,0.048023686,0.057680942,-0.011177659,0.0034021318,-0.099431604,-0.025502348,0.00725698,-0.08609576,-0.0044251326,0.007436881,0.02319207,-0.1326243,-0.007268373,0.05812511,-0.03964335,-0.02688701,-0.036121786,0.032365978,0.01166064,0.039929736,0.04033705,0.06637022,-1.1829625e-33,0.07692237,-0.10145435,0.036614425,0.106340624,-0.037608594,-0.0139248585,0.039688535,-0.021755768,0.039422933,0.062537864,0.052969225,0.018399572,-0.041846104,-0.054007396,0.12580882,-0.05880424,0.054991387,0.036643602,0.048074402,-0.0103850365,0.014824521,0.11064252,0.0090095615,0.060058657,0.06344752,0.008246162,0.0020392726,0.06415868,0.013741527,-0.010481031,-0.0569124,-0.025424957,-0.061031662,-0.037169743,-0.052581847,0.058102056,-0.02196662,0.058555286,-0.020801235,0.015705692,0.019014142,0.0058659483,0.048243072,0.06089786,-0.029045107,0.05085077,0.059592377,0.0610982,-0.054606553,-0.018097721,-0.03354772,0.016611755,-0.00571977,-0.018857054,0.062217616,0.011707449,0.0575212,-0.02141767,-0.048295982,-0.07471973,-0.012035082,-0.015778964,0.054231066,-0.06901813,0.042669013,-0.078027345,-0.021258358,-0.03781907,0.025046013,-0.006901756,0.04760661,0.011062078,-0.06858556,0.03565283,-0.013938036,-0.013233317,-0.012599449,-0.08034671,0.025654955,-0.08207069,-0.020337688,0.047245324,-0.07523219,0.0075311363,0.026372831,0.011741359,0.028634882,0.027052468,0.073501475,0.0680901,0.011325841,0.006919228,0.006451344,0.033021227,-0.02046177,-2.087875e-08,-0.009151594,0.017026274,0.052912496,-0.0060821697,0.019105446,0.018720562,0.0018060984,0.07247144,0.060666967,0.014044685,0.027781945,0.047153674,0.044840924,0.044175103,0.016597455,-0.046853736,-0.02240538,0.044922076,-0.052405667,0.030142998,-0.044015307,-0.019763386,-0.09037278,-0.030500136,-0.14094996,-0.10495809,0.013932739,0.067881666,0.01446754,-0.0023525194,0.04336724,0.026791047,0.028380139,-0.022491265,-0.029635716,0.081784196,-0.044335928,-0.048656132,-0.04133151,0.07914091,0.017819138,-0.05975599,0.0033655711,0.0022345947,-0.03342217,-0.06828932,-0.010692417,-0.1104902,0.049024284,0.018899772,0.11696776,-0.008582657,-0.06852806,0.050355244,-0.036829162,0.008280401,0.008110602,-0.05941481,0.07345161,0.011135537,0.016840853,-0.053361848,0.011646843,0.0016444571 +3.2.1.102,"Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to a 1,3-alpha-D-galactosyl or N-acetylgalactosaminyl residues and a 1,2-alpha-D-fucosyl residue.",384,1.0,0.014783711,-0.108035,-0.017879535,-0.0046257847,0.042183846,-0.0407535,0.03919925,0.025542147,0.03381343,0.00022150595,0.03261372,0.06567117,-0.054474898,0.06540244,-0.12722658,-0.0028359813,-0.046156745,0.054680668,0.007970956,0.12093998,0.08820163,-0.022672705,-0.010123197,0.07024063,0.07284019,-0.0054391287,0.04703847,-0.038685832,0.006767072,-0.0716305,0.02893298,-0.014029224,0.03298161,-0.061518546,0.053741623,-0.010026525,0.046819188,-0.026918914,0.037584085,0.023267755,0.011692134,-0.01638195,0.06601561,-0.026439333,-0.05520262,0.00038999048,-0.054736916,0.10098729,0.07128727,0.035086576,0.06722892,-0.09633445,-0.086616054,-0.0015821217,-0.0060105766,0.06617065,-0.014937342,-0.07127331,0.007648146,0.12673952,0.089193255,0.078453876,-0.032150928,0.044354677,-0.039066114,-0.054182302,0.03625187,-0.049888518,-0.035505485,0.026535263,-0.050921645,-0.060216356,-0.023095325,-0.0571639,0.027002491,0.045206726,0.035272013,-0.047024187,0.048337307,-0.032183103,0.02507706,0.0057953075,0.06409978,0.027440807,-0.010414808,0.0039790254,0.004786729,-0.014113218,0.057173487,0.014463368,0.0039309557,-0.06355394,0.03475503,-0.07492323,0.0069080577,0.02152882,0.07995598,0.011669985,0.07834585,0.022999257,-0.05915822,-0.006573346,0.04419566,-0.043468673,0.00074174796,0.06718543,-0.029010516,0.033020232,0.021630496,-0.04464325,-0.045382157,-0.044866208,0.03924788,0.0006329962,-0.10044184,-0.02255349,0.010250058,-0.053832408,-0.032389972,-0.041693483,0.015323012,-0.012094638,0.068978816,0.007903766,-0.025605265,0.070386216,0.00380364,-1.2185208e-33,0.069564566,0.07000145,0.06201311,-0.025535896,-0.008008604,-0.036690846,-0.06216358,-0.07047085,-0.02104342,0.025322635,-0.062145166,0.02413471,-0.002314388,0.014428554,-0.012041078,0.056237046,0.060571205,0.017248742,-0.002783373,-0.05269535,-0.044784833,0.039453942,-0.070715554,-0.005926025,0.061661366,0.019601066,-0.07926419,0.034261797,0.13074377,0.030816332,-0.0185428,-0.020245714,-0.07940142,0.03051729,-0.027076835,0.06875688,-0.053546596,-0.098638594,0.035045266,-0.02250915,0.053072684,-0.0021556895,-0.00027060547,-0.030600453,-0.038395908,0.017529331,0.024812799,0.05385052,-0.02165153,0.037961923,0.017060515,0.010231614,-0.016244017,0.009241638,-0.033148266,0.008394557,-0.0698067,-0.056110777,0.028064761,0.06939949,-0.029065982,0.03612243,-0.034688983,-0.0042150617,0.037938006,0.0033312747,-0.007541965,0.0057620388,0.020475952,-0.04962868,-0.084045134,-0.028794013,0.08477711,0.02991317,-0.016703783,-0.062268876,0.042530082,-0.006691633,0.0314079,-0.0052622617,-0.050861884,0.042891808,-1.8288682e-05,-0.026901398,0.013232923,0.0439546,-0.0019737026,-0.024595164,-0.020385992,0.0059955963,-0.021442793,-0.029202508,-0.015763877,0.026290637,0.00013963023,-1.7188093e-33,0.063543744,-0.11217684,0.050451756,-0.021331701,-0.04831037,0.06894791,0.04167954,0.0017679118,0.034785517,-0.055554055,0.03133473,0.009245595,-0.06069853,-0.14066947,0.03098634,-0.022827161,0.065960154,0.0630859,-0.05951978,-0.004424807,0.07616849,-0.009615372,0.048953604,0.04088943,-0.022682656,-0.057531267,0.041328847,-0.085871376,-0.026883794,0.12553054,0.04158502,0.017136311,0.02042853,-0.07488829,-0.0042754095,0.008273284,-0.05427872,-0.0010689492,-0.005822088,0.017822888,0.019090896,0.04189047,0.06606713,0.057026826,0.09481885,0.08106478,-0.09271954,0.01743531,0.017461762,-0.035081718,-0.033255797,-0.07300357,-0.023832886,0.06561591,-0.027985075,0.04394434,0.0315794,0.067354254,0.0116760675,-0.015182107,0.0027461902,0.0053550317,-0.04372152,-0.10434597,0.033195663,-0.048818044,-0.049424328,-0.0098477155,0.025772093,-0.033570167,0.015012257,-0.034699425,-0.0012312513,0.05010414,0.04170347,-0.070635475,-0.10398959,-0.11102581,-0.050157227,-0.010016737,0.02258705,0.1147963,0.0023878603,-0.0038195164,0.030281618,-0.06973138,0.048405424,0.122755006,-0.024282277,-0.012907271,-0.037661135,0.04534406,-0.02187118,0.07217081,0.09507027,-3.6310855e-08,0.080172084,0.02563294,0.031775665,-0.090489164,-0.057071824,0.056740064,-0.026979659,0.07825623,0.017417446,-0.060768697,-0.018702935,0.13359311,-0.051872194,0.004376688,-0.02133155,0.051822476,-0.06420293,-0.04269828,-0.05314783,0.0070209876,-0.05649773,0.05336185,0.011195539,0.00045829118,-0.10621866,-0.033349615,0.08374284,0.05463682,-0.09531252,0.008683341,0.08120712,0.033547226,-0.11959834,-0.0417364,-0.0487466,0.021622954,-0.01966401,-0.03341016,0.034657337,0.068543606,0.032007884,-0.082250014,-0.0021371255,0.009873146,-0.06669985,0.007648772,-0.059501626,0.05666512,-0.076529436,0.04538398,-0.01905385,-0.015501966,-0.1311568,-0.05351778,-0.057812933,-0.07586389,0.03834065,-0.02797497,-0.025441922,-0.07791629,0.027242715,-0.042135444,0.12260234,0.008536558 +3.2.1.103,"Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to 1,3-N-acetyl-alpha-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC 3.2.1.102 blood-group-substance endo-1,4-beta-galactosidase).",384,1.0,0.0146872,-0.11415378,-0.031265806,0.035208862,0.03228249,-0.024324862,0.01339495,0.004900082,0.07230466,-0.0065267584,0.056402963,0.09343369,-0.10248425,0.07928699,-0.11357394,-0.0023567234,-0.009144789,0.039210096,-0.030242227,0.047027852,0.100526616,-0.049832728,-0.04001632,0.04864141,0.07398371,-0.026558291,0.036971644,-0.052638832,-0.009530341,-0.08419726,-0.004240363,-0.032440793,0.011305047,-0.04401703,0.025718428,0.028789265,0.036815174,-0.046201866,-0.011446209,0.014036477,0.05778735,-0.07181448,0.0166304,-0.036125574,-0.034906384,-0.029432725,-0.049302284,0.084105484,0.053764105,0.039864603,0.023794696,-0.07775062,-0.08236396,0.038262345,0.01286656,0.03739568,-0.06451033,-0.06297277,0.016880339,0.06716004,0.06050961,0.0817325,-0.027311366,0.039786298,-0.039620057,-0.082500905,0.07562995,-0.03509949,-0.055452455,0.017496346,-0.02036858,-0.038400907,-0.01551995,-0.015563543,0.0403872,0.06508314,-0.019424206,-0.043552853,0.04108667,-0.039814882,0.036185972,0.020045303,0.084315784,0.04993224,-0.009156317,0.012810392,-0.043448415,0.021566948,-0.015284684,0.009498877,0.022823725,-0.026954114,0.04330226,-0.03471685,0.03606264,-0.0363154,0.08223658,-0.019535447,0.078936666,0.011308779,-0.056152508,-0.021145567,0.039508212,-0.02943445,-0.00047822503,0.06541516,-0.01007428,0.043346886,0.04783731,-0.016379118,-0.0517081,-0.055535365,0.047857866,-0.07054191,-0.10148563,0.019149356,0.011009399,-0.015651032,-0.05617124,-0.021078574,0.02050127,-0.030095946,0.06672519,0.039406985,-0.008625983,0.10060195,0.056462925,5.279925e-34,0.08826811,-0.003228186,0.07231599,-0.017438937,0.012998198,0.009598827,-0.0479108,-0.054727316,0.020642444,0.047960285,-0.06882925,0.0018827406,-0.008064222,0.093966834,0.0052279895,0.06746488,0.030314883,-0.07238476,0.03313301,-0.009041879,-0.027105222,0.08635792,-0.059073232,-0.048739627,0.027661897,0.017661829,-0.11293063,0.05671518,0.08324363,0.041300893,0.03080445,-0.033667613,-0.082674,0.010622825,-0.018532034,0.09093786,-0.061091125,-0.091103494,0.027898222,-0.03687902,0.045716792,0.014230232,-0.06585518,-0.055358063,0.0048987623,-0.02374816,-0.02145226,0.008618876,-0.03559096,0.042838093,0.040009826,-0.0019300784,-0.00321188,0.012075903,-0.022171544,0.002321535,-0.054404516,-0.029917413,0.00444138,0.10554885,-0.0036348377,0.072222576,-0.02176521,-0.05150635,0.0076386104,0.03287782,-0.00951924,-0.015012947,-0.029003417,-0.0969619,-0.07535348,-0.007482642,0.031507574,0.014568209,-0.036677465,-0.058351956,0.042342663,-0.0035777031,0.029389208,-0.030791176,0.029280124,0.01012546,0.048820257,0.010727602,-0.02150651,0.06009994,-0.008957487,-0.08935212,-0.051957738,0.0016315004,-0.015489065,-0.018575309,-0.041722078,0.05098673,0.037860826,-3.7569505e-33,0.100744784,-0.094243795,0.05914123,-0.04839798,-0.025091322,0.04415484,0.061865047,-0.010812908,0.040740225,-0.00046193617,0.05113102,-0.009346316,-0.048139818,-0.07126635,0.0049697584,-0.00805454,-0.010216801,0.06736143,-0.066140436,0.011601232,0.00045713407,0.05953311,0.10412191,0.036578763,0.05771651,-0.06719994,0.018603006,-0.05267891,-0.0057056868,0.077415764,0.05721266,0.023850596,-0.03562583,-0.1205565,-0.02549981,-0.015258867,-0.071698144,0.027924107,0.027640032,-0.0022546153,0.0531302,0.022780241,0.06480685,0.038801603,0.10012851,0.11309818,-0.08146597,0.01641836,-0.008388952,-0.04654244,-0.061446387,-0.028771397,-0.014355787,0.10315279,0.05193337,0.052494127,0.06356886,0.011372173,-0.018879132,-0.06341421,-0.03588418,0.0084730685,-0.0058518215,-0.1018129,0.085601434,-0.02034213,-0.022863029,0.0075635817,0.05642925,-0.03384199,-0.011657071,-0.069999285,-0.006546542,0.01106294,0.017007055,-0.029033057,-0.15836538,-0.11481108,-0.045327146,-0.020504536,0.013916088,0.067869276,-0.010363156,-0.03663113,0.037009537,-0.09850325,0.040107675,0.131538,-0.013117694,0.029779816,-0.021906683,-0.0035751355,0.013572948,0.034817755,0.021658545,-4.440252e-08,0.06873185,-0.0061226105,0.031269588,-0.072597496,-0.08101753,0.008410421,-0.022956377,0.088649966,0.044616833,0.0048573297,-0.033198755,0.16726582,-0.019338846,0.0016949739,-0.014994183,0.065620124,-0.04004342,-0.046786997,-0.0138627235,-0.047245044,-0.08514731,0.002363803,-0.033115573,0.02058039,-0.066619925,-0.0825728,0.07777782,0.030024715,-0.06521821,-0.008228304,0.06479373,0.03994515,-0.0868581,-0.021993738,-0.032047734,0.044775605,-0.05540187,0.014418248,0.021756412,0.02621012,0.022230174,-0.025687039,-0.018484179,0.011649322,0.00048975914,-0.012688042,-0.0020512827,0.06992144,-0.082443,0.037595212,-0.022670979,-0.03631898,-0.13855389,-0.04582429,-0.044924255,-0.079659306,0.016492091,0.011829754,0.01645307,-0.07374098,0.0012140017,-0.04676157,0.10183729,-0.01599646 +3.2.1.104,"Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol.",384,1.0,-0.04017878,-0.1084364,-0.06650386,0.016751703,-0.025899965,-0.034912962,-0.06786139,0.027347801,0.06121532,-0.089563884,0.028111871,0.042789403,-0.028595153,-0.04241546,0.007046861,-0.0033148758,-0.008683967,0.03463295,0.045611646,-0.02057928,0.003204776,-0.011082281,-0.06282966,0.014855888,-0.09344328,0.023038363,0.0048223636,0.008190915,-0.012990571,-0.04489873,-0.0470125,-0.009695999,0.06114837,0.004561019,-0.032851283,0.039925557,-0.043973982,0.00044987246,0.039514475,0.0046781655,0.052899837,-0.092177674,-0.0086663775,-0.024228474,0.030284543,-0.079819724,-0.013088146,0.024130968,-0.0603291,0.09173217,-0.017495627,-0.03493305,0.0008043912,0.024087455,-0.061418504,0.013958198,-0.059172023,-0.028263023,0.03154259,0.013480318,-0.037033,-0.017412169,-0.06086084,-0.011916697,-0.11672331,0.024123067,0.011811429,-0.04025424,0.038834415,0.049079143,-0.037908893,0.02193295,-0.01994017,0.03213183,-0.033167947,0.046792053,-0.05224847,-0.10038029,0.035754133,-0.07559449,0.093342006,0.0058182226,-0.024834674,0.07263475,0.055742554,0.01862255,-0.047201574,-0.015773168,-0.05410912,0.02123175,0.070832655,-0.0018412054,0.027441384,0.033955887,-0.018849863,-0.047835298,0.014073865,0.024633158,-0.03152612,-0.06795643,0.021921705,0.04150761,-0.053752538,0.01599386,-0.02975268,0.018579599,0.022098398,-0.04388746,-0.0585729,0.019214837,-0.058106013,0.0038595826,0.033841386,-0.046122774,-0.07845218,0.055503502,0.05362112,-0.041121677,-0.10587219,-0.016322574,0.0015265758,0.01894187,0.0034074993,-0.025576733,0.004279876,-0.0073934025,0.094795026,8.223683e-34,0.034261223,-0.016582942,0.06822641,-0.007845439,0.037089232,-0.032843027,-0.02720985,-0.01458227,0.07238783,-0.0050120205,-0.0055970782,-0.048292544,0.0036945797,0.061821964,-0.016996792,0.06662063,0.073419675,0.016938562,0.083438024,-0.07577728,-0.025275385,0.1425676,-0.065109275,-0.039936997,-0.038989186,0.0039485563,-0.033603035,0.021172551,-0.04838726,-0.0024529484,-0.00606492,-0.06441841,-0.025013013,0.0485964,0.089899234,0.12237346,-0.04862144,-0.025097843,-0.05771613,0.049922336,-0.0116142025,-0.020697948,-0.07513569,0.03085997,-0.005523595,-0.00786522,-0.08801639,0.023892904,0.011092996,0.06671739,0.01597366,-0.007972471,-0.018912645,0.030900946,0.03340385,0.013062468,-0.008162242,0.015121522,-0.012149473,0.05144344,0.03222384,0.10224056,-0.034891814,-0.022642026,-0.05227908,0.04993085,-0.114329375,-0.05403401,-0.08963455,0.04511124,0.039184537,0.026513573,-0.01832638,0.061369475,0.09634522,0.043543927,-0.023299191,0.069031626,-0.031770896,0.0027962439,-0.0018763092,-0.08901517,0.056825876,-0.0006709256,-0.110772766,0.027065838,-0.014756511,-0.009428466,0.022730093,-0.015259056,-0.011770196,-0.05093806,-0.04891033,0.05097884,0.021868812,-4.110648e-33,-0.06817592,-0.06337574,0.073344246,-0.0144590065,-0.07699652,0.06768181,-0.04612113,-0.09053325,0.048363045,-0.0055492753,0.0119081475,0.07209216,-0.04579554,-0.018600428,-0.036352243,0.08899381,-0.045749594,-0.001591536,-0.091241166,0.0066143484,-0.047698345,0.057489723,0.073543794,0.18359338,0.05721345,0.017132875,0.07618623,-0.04040704,0.074538924,0.07180141,0.09933448,-0.028780142,-0.01251562,-0.05136073,-0.06585578,0.006757886,-0.03525964,0.047973886,-0.035144854,-0.018484863,-0.08916197,-0.06587051,0.08838017,-0.048007935,0.04865094,-0.032164212,-0.010436484,-0.026162587,-0.046942674,-0.07053408,-0.014485181,0.061331015,0.023574105,0.05661938,0.12184755,0.07433653,0.015156676,-0.055852234,0.057435844,-0.10398813,-0.02068588,0.0468093,-0.07536131,-0.083795,0.07172595,-0.046562493,0.032476958,-0.05045985,0.08800499,0.004458352,0.0289266,0.037553225,0.02165708,0.031249825,-0.06502898,0.067251645,0.024284976,-0.036172215,-0.056744717,-0.033703648,-0.02311894,-0.034255132,0.1081933,-0.021590736,-0.11106438,0.007483301,-0.015148355,0.0106609175,0.032629665,0.05815287,-0.020657333,0.04540518,-0.073437944,0.0076482105,0.016275754,-2.4811923e-08,0.039281063,-0.024299663,0.010083055,-0.05532652,-0.1496732,0.00016577842,0.02856686,-0.0260102,0.03644485,0.031519644,-0.06169978,0.122760534,0.092690945,-0.056253187,0.0077486266,0.008633353,0.028078163,-0.01739861,0.011716913,-0.027737213,-0.070825785,-0.022456406,-0.02179205,-0.023606045,0.010579332,-0.068980485,0.0736441,0.040421784,0.030287057,0.051158696,0.07448759,-0.0040694815,-0.019784776,-0.021050911,0.10771121,0.058561563,0.038339376,-0.044477206,-0.04800509,0.10807341,-0.029662218,0.004164343,-0.0022433132,0.036703575,-0.035002235,-0.02794647,0.018778497,0.020304985,0.02238677,0.020071562,-0.02698396,-0.0012969769,-0.045197256,-0.005300504,-0.03236373,-0.0076045366,0.009738839,-0.014712631,0.03418174,-0.03917262,-0.031478796,-0.019706069,0.121168695,0.1115631 +3.2.1.105,Does not act on a number of closely related glycosides. Strictosidine is a precursor of indole alkaloids.,384,0.99999994,0.0305714,-0.08742841,-0.0737148,-0.052149177,-0.06970716,-0.0052192393,-0.07545168,0.012163048,0.015703766,-0.0059081083,0.08131986,-0.006511989,-0.052627824,0.07156586,0.014106934,-0.01829977,0.045596868,0.0045486786,-0.05351795,-0.043816153,-0.0061080935,0.057476655,0.059277352,-0.0009065584,-0.030407414,-0.009823088,0.013371569,-0.021189215,0.031001247,-0.045277584,-0.09452894,-0.030457018,0.061758313,0.011729414,0.011677424,0.03331336,-0.1138284,0.049777765,0.14738728,0.058192793,-0.06667057,0.023497408,-0.03717491,0.03441329,-0.06075507,-0.05165423,-0.045867864,0.028478278,-0.0061556706,0.042229813,-0.015980458,-0.06127107,-0.023983378,0.01189174,-0.0055448655,-0.0077560535,-0.13126667,0.12275145,-0.0013018012,0.072119854,0.01565131,0.028396325,-0.0047124806,0.0003581208,-0.04633859,0.0059597366,0.036713317,-0.0048055644,0.04105965,-0.020049587,0.06691603,-0.0739687,0.025510015,0.043108672,-0.03377044,0.0080703795,-0.0657388,-0.004615997,-0.045518264,-0.089211196,0.032952324,0.014178552,0.020685669,0.033932954,-0.050409857,0.030424237,0.014637932,0.0014029267,-0.04433537,-0.036715236,0.13654885,-0.055643044,0.0334894,-0.04895954,0.059070945,0.05064984,0.03430599,-0.0005898772,-0.07164874,-0.027144387,0.052231453,0.032137938,-0.12144506,0.0047905263,0.007878875,0.08035468,0.021753177,-0.07010634,-0.04046644,0.013595564,0.025584366,0.051059045,0.0026522386,-0.041556243,-0.07631291,0.0031313426,0.07877115,-0.013038051,-0.035201326,0.0034915858,-0.032742154,-0.022775939,0.035372663,0.07798087,-0.023860388,0.015124027,0.0082866745,4.822296e-35,0.08595437,0.006301106,-0.022105007,-0.061475787,0.0065372605,-0.04573795,0.024231777,-0.022313794,-0.061728477,0.025979798,-0.08701884,-0.031045487,0.025944747,0.009302419,-0.0038158847,0.0304313,-0.05145824,-0.02444012,0.0975058,-0.049203563,-0.030050574,0.063244835,-0.0022837685,-0.10711701,-0.09144361,0.019064588,-0.006541645,0.030987011,0.045140512,-0.04124041,-0.055498473,-0.032544848,-0.018882772,0.06554863,-0.037008848,0.07029138,-0.10313152,-0.063401826,0.027594753,0.032792762,-0.019093195,0.08738956,0.028890327,-0.009245501,0.06982886,-0.01043235,-0.06730871,-0.0023451024,0.014673506,0.04681343,0.015223683,-0.033052698,0.016468178,0.010544626,-0.03634532,-0.0054810704,0.06048361,0.027734904,-0.010230094,0.11658635,0.03001846,0.040088136,0.007051884,-0.016461693,-0.018610394,0.030926934,-0.13587627,-0.040463246,0.013607191,0.014616148,0.001501583,-0.08385464,0.03920847,0.0042848093,0.033585582,-0.016169142,0.0061392877,0.022866312,-0.009907271,-0.046508018,0.005187818,-0.039318,0.066492505,0.083263874,-0.086579815,0.013360866,-0.0149883535,-0.036609285,0.021479208,0.086248025,0.026230156,0.011082717,-0.08415534,0.087796465,0.0114043,-1.7494195e-33,0.079337284,-0.073643014,0.019280031,-0.039645776,-0.022634251,-0.009133402,-0.01841544,-0.080733575,0.04062744,0.08655932,0.09756942,0.00493005,-0.018124387,-0.0009364146,-0.04941332,0.0003314326,0.057251386,0.14836906,-0.021932812,0.02517432,-0.05565299,0.007636014,-0.04985934,0.08736592,0.08032008,-0.0036974566,0.032762013,0.00021418589,-0.05468094,0.03197027,0.03570211,-0.009809065,-0.12429201,-0.10812064,0.10344746,-0.002061156,-0.024180114,-0.03349527,-0.0036439463,-0.10931116,-0.002080781,0.09787088,0.04905279,0.04362178,0.09562156,0.022332873,0.0015697114,0.012697342,-0.09401963,-0.071257256,-0.0027493872,-0.033910733,0.04410485,0.06077657,0.09788355,0.011906434,0.015865805,-0.021824166,-0.0078392355,-0.0052293222,-0.029302968,-0.04217168,-0.013162653,-0.077915736,0.08148121,0.036856968,-0.086336695,0.031933717,0.062526986,0.020240573,0.010565933,-0.09207218,0.0032424615,0.04999232,-0.07892836,-0.067573935,0.014415699,-0.099046215,0.075532,-0.012157798,0.043246746,0.03385961,-0.011322348,0.0019518589,0.017035779,0.006771736,0.008323226,0.049114164,-0.0049198563,0.067822665,0.04533164,-0.042552277,0.024088576,-0.023489453,0.052031618,-2.4874696e-08,0.085099585,-0.0131050795,0.0025412499,0.009841294,-0.058694605,-0.0035323093,0.042198956,0.00023168973,-0.050811723,-0.03961217,-0.05445937,0.02769176,0.02625678,-0.03571513,0.0035091392,0.04372681,-0.054691996,0.039998565,0.0018497936,0.024961779,-0.10773343,0.037797388,-0.053306706,-0.016404582,-0.010952342,-0.021007294,0.091684096,0.008559768,0.06885914,-0.041885253,0.062094204,-0.039574128,0.03322332,-0.06341389,0.021023775,0.02834726,0.032779764,0.03156971,-0.007420776,0.02351537,-0.05746021,-0.054813284,-0.013977701,0.028427674,0.037044834,-0.05970491,0.03479589,0.0025373306,-0.00015028831,-0.042871825,0.041021954,-0.024294645,0.06299911,-0.06315667,-0.0651467,-0.10222371,-0.07820352,-0.040117472,-0.00594806,-0.0825453,0.038840257,-0.0026833927,0.16016379,0.044221833 +3.2.1.106,"This enzyme catalyses the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue. This and subsequent processing steps are required before complex N-glycans can be synthesized.",384,0.99999994,-0.026802618,-0.009188115,-0.13867193,-0.01711903,-0.029464783,-0.05431484,-0.010323946,-0.001895891,0.0004922013,0.02759988,-0.027993288,0.07584544,-0.037891593,-0.015939351,-0.09724172,-0.107351124,-0.0147785,-0.043376446,0.0541405,-0.050007034,0.05831582,0.015250682,0.050416846,-0.027074069,0.021166565,-0.032848686,-0.00018447849,-0.019707145,0.062523484,-0.056373537,-0.017306522,-0.0833705,0.009068086,-0.014256336,0.007631832,0.08034625,-0.04491613,0.010532431,-0.06800453,-0.015155771,0.004482438,-0.046830375,0.0016709656,0.015107866,0.0445365,-0.052108184,-0.02967765,0.027391886,0.023357503,0.08164573,-0.0057862005,-0.06372582,-0.06651084,0.053016484,0.10339239,0.064594194,-0.097374484,0.022189315,0.077422984,0.06770451,0.036266636,0.016586605,0.027577188,-0.0584203,0.044091668,-0.051423978,0.07457022,-0.058300182,-0.04053517,0.03859423,0.017706791,0.013398571,-0.08111136,-0.058023088,-0.03118618,0.050443035,-0.051718272,0.03877058,0.033269215,0.041946866,0.11567328,0.040681176,0.06146928,0.113639176,-0.047975395,0.0059259683,-0.03677927,0.035209645,0.08969198,0.00939552,0.015819395,-0.032462902,0.017887205,0.00042301006,-0.037854698,0.005921055,0.006020417,0.025393952,0.026702909,-0.057947483,0.017161235,0.028899547,0.08235778,-0.07481561,-0.08692,0.09130037,-0.012882508,0.10568121,0.07044231,-0.0046640467,-0.04322229,0.0690099,0.034040038,-0.037342098,-0.07919963,0.101728864,-0.03337549,-0.048899356,-0.013407081,-0.049136203,-0.0030883343,0.028403062,-0.014738686,0.0025508506,-0.0028068887,0.08122354,0.017268598,2.1032147e-33,0.058308687,0.051058672,-0.035256576,0.034940377,0.021347277,-0.011145361,-0.042969238,-0.030167878,-0.04353481,-0.0025014896,-0.0032331008,-0.019235943,-0.04465695,0.1119099,-0.012018418,0.03328251,0.020847753,-0.051268794,0.009113272,-0.011808991,0.003673655,0.058701452,0.028688,-0.051136173,0.08581364,0.09953359,-0.04797302,0.031788915,0.06851356,-0.034278166,0.0290066,-0.07173058,-0.08641523,0.021479255,0.12535636,-0.00052616367,-0.002244882,0.012305787,0.06389367,0.069607854,0.053932715,0.040976524,0.03340443,-0.060490865,0.032457784,0.044280622,0.038147572,0.06512852,-0.0018262939,0.04596958,0.08311163,0.022797564,-0.013322784,0.05820657,-0.097067185,0.056941096,0.0058892476,-0.03520541,-0.021055013,0.013612081,0.015354528,0.025652653,0.008185119,0.031809755,-0.013298023,-0.007008491,-0.08250276,0.03011592,0.021230342,-0.018880093,-0.014536371,-0.060895193,0.117572814,-0.009128828,0.032737687,-0.021009928,-0.000319212,0.001233581,-0.017478298,-0.069485754,0.003557425,0.02900706,-0.04634254,-0.00425887,-0.04555187,0.04167204,-0.004733349,-0.080109105,-0.04260706,0.042165413,-0.027852353,0.00813639,-0.015421578,0.029546693,-0.06798921,-3.5332646e-33,0.11971913,-0.1386138,0.104613155,-0.04938141,-0.06317987,-0.023909582,0.0055984976,-0.11634473,0.022348845,-0.028889518,0.028093575,-0.01420339,0.063310094,-0.010880465,0.06698381,-0.040139355,-0.034523513,0.1149472,-0.053328596,-0.089544475,0.009183831,0.025816351,-0.049927145,-0.0029357823,0.027266307,0.016800975,0.07987116,0.051730894,0.045349907,0.014352145,-0.10056198,-0.04068141,-0.019442031,-0.02590178,-0.0013427739,0.025695,0.002519015,-0.022279415,0.012886332,-0.06156102,0.06295913,0.088833384,-0.009186227,0.016200826,0.024706522,0.044904415,-0.06664429,0.041797295,-0.046113037,-0.027214864,0.052297153,-0.014145824,-0.07311954,0.021583889,0.050798368,0.09716894,0.060213387,-0.0011496168,0.045457695,-0.032013677,-0.016784396,-0.004669361,0.02778723,-0.061433274,0.0801563,0.03631528,0.021153973,-0.0024411543,0.025888238,0.0029449218,-0.017666819,-0.030077184,0.004300072,0.024207499,0.013557526,0.001406122,-0.07994888,-0.058397807,0.0023781518,-0.12912545,-0.0005577175,-0.034657504,0.048886206,-0.045332834,0.07529125,-0.05086532,0.03730896,0.11730806,0.0012854664,0.035820276,-0.015373282,-0.043285634,-0.015367011,0.023586277,0.03231523,-3.5989363e-08,0.01598058,-0.066502035,-0.06450603,-0.07725344,-0.030036062,0.03181734,-0.006236248,0.03197977,-0.0057958975,-0.05126907,0.0007525564,0.030883845,-0.028612401,-0.025518678,-0.058570966,0.07755555,-0.06873213,-0.037777822,-0.04450469,-0.021729663,-0.13257556,0.0027761667,-0.09623596,0.046429627,-0.03292288,-0.054678176,0.009442869,0.06755005,-0.011110716,-0.033297937,-0.0210286,0.041340884,-0.016206888,-0.058141384,-0.0051390813,-0.054476503,0.030628446,0.011059998,0.0226498,-0.041159622,0.007928551,-0.00012915923,0.009578371,-0.00079398043,-0.12529796,-0.05290734,-0.004993331,0.020934528,-0.057641596,0.13685782,0.017236806,-0.029193379,-0.036690492,-0.0998395,-0.06648952,-0.08575957,-0.050421234,0.02773096,-0.040221952,-0.040764846,-0.023468643,0.030105814,0.11975177,-0.0576264 +3.2.1.107,The enzyme specifically hydrolyses glucose from alpha-D-glucosyl-(1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins. Acetylation of the epsilon-amino group of the glycosylated hydroxylysine abolishes activity.,384,1.0,-0.052288275,-0.061795004,-0.027905334,0.046476863,0.026719207,0.0032552741,0.00231426,0.029775212,0.016980879,-0.012624689,0.011044449,0.11378458,-0.05521356,0.05903366,-0.09736723,-0.070008926,-0.009765408,0.049455184,-0.041522857,-0.025714595,0.08511484,-0.018294143,-0.02095483,-0.009605025,0.13538751,-0.078324676,0.06439051,-0.06853675,-0.014382358,-0.017277174,-0.009123322,-0.07572927,0.003562237,0.034999557,0.04702835,0.102208294,0.058297142,-0.07868149,0.039654598,-0.02735139,0.044121727,-0.041149702,0.00803567,0.009823305,0.040638395,-0.043194946,-0.017397387,0.047744874,0.03564093,0.07161447,-0.02009602,-0.08831144,-0.04398881,-0.02279514,0.015229525,0.05208854,-0.05026042,-0.0401369,-0.031460777,0.02742236,0.008020032,0.05148271,-0.037488442,0.013558452,-0.04931759,-0.09328477,0.069547586,-0.0045742346,-0.044328555,0.021375673,-0.027145956,-0.0094471695,0.034078706,0.0006232248,0.036876783,-0.041344415,-0.11790719,-0.0007822526,0.05614207,-0.018070208,0.08730121,0.0006350964,0.09289751,0.0874801,-0.015458644,-0.02440341,0.06891986,-0.0028692158,0.03157074,-0.057721935,-0.05127686,-0.052997183,-0.01387266,-0.006487111,-0.009733629,0.018361192,0.055758312,-0.0185153,0.03402956,-0.0031770472,-0.03979543,0.004123922,0.10408318,-0.036688875,-0.05834678,0.045445815,-0.033067185,0.12988956,0.081142,0.017620588,-0.0077980096,0.04023564,-0.0010091935,0.04321092,-0.0726939,0.05188282,0.009421275,-0.10107623,-0.030392325,-0.01233886,-0.02464425,0.0096035665,0.12617722,0.013802698,-0.087426096,0.11105013,0.020530207,1.5933811e-33,0.050176144,0.00846002,0.00705452,-0.055127252,-0.04082183,0.007324622,-0.096793175,0.025191082,0.0031168365,0.023599396,-0.05961515,0.022689212,0.02880858,0.06253691,0.01351879,0.05788047,0.020383244,-0.028127324,0.11360041,-0.008113447,0.008504938,0.07750623,-0.027038416,0.010237683,0.029309794,0.01810361,-0.0687634,0.062594794,0.07177967,0.029167796,0.018783126,-0.03565418,0.014333973,-0.010856278,0.062149987,0.036071092,-0.052640874,-0.041270312,0.041487277,0.019700818,0.097504415,-0.026283111,0.060703926,-0.14478086,0.006521695,0.007602917,0.011049436,0.035661966,-0.023246547,0.040483154,0.0634619,0.017266944,-0.020850819,0.0078100767,-0.045245994,0.040176965,-0.029021185,-0.00016501868,-0.0054526306,0.04536486,-0.0196634,0.01137022,0.029043108,-0.03691294,-0.029435836,-0.025227789,-0.083247006,0.0088214725,-0.058779255,0.035372254,-0.09552356,-0.07148666,0.02996241,0.00899595,-0.008711537,-0.08330228,0.061576944,0.05298902,-0.027397446,-0.022214929,-0.00053763064,0.04638484,-0.050430696,-0.045689132,-0.023335781,0.045049883,0.009396223,-0.06995542,-0.012224251,-0.0028427166,-0.0059506116,-0.010614508,-0.07247513,0.052942727,-0.008161389,-4.5904946e-33,0.060742002,-0.10791149,0.02905312,-0.036243092,-0.038940415,0.001736391,0.10941366,-0.019552827,0.035348292,-0.014191791,0.04087046,0.018234314,-0.09561848,-0.076960735,0.011909136,0.049480595,-0.0324769,-0.004976614,-0.048042268,-0.0016160473,0.01764733,0.07521898,0.076667264,-0.0057572364,0.097951144,-0.028766494,-0.0015266336,0.06528385,0.008462732,0.083015814,0.015352839,-0.04170132,0.017320564,-0.043878257,-0.06251445,-0.005400131,-0.05583988,-0.016432201,-0.033876967,-0.049789835,0.047551513,0.052483097,-0.011944662,0.07230292,0.11153511,0.08889923,-0.052191693,-0.02706984,-0.050226983,-0.04916178,0.01887142,-0.06452139,0.013410176,0.030689146,0.006298601,0.036426645,0.035077803,0.07198525,-0.04334032,-0.0047530797,-0.027665561,-0.03624264,0.037890084,-0.020034306,0.091722295,0.015591369,-0.046536747,0.014282312,-0.0069555175,0.059923388,0.012348591,-0.053317968,-0.017220294,0.07998209,-0.0020470654,-0.0027444512,-0.12290766,-0.037938695,-0.09326227,-0.07345568,-0.008778756,0.027085105,-0.03373419,-0.07591664,0.002633456,-0.033944905,-0.001032092,0.13133627,0.051033206,0.04154022,-0.016506074,-0.0038929982,-0.031020122,-0.028762965,0.039687112,-3.804207e-08,-0.036899548,-0.029165257,0.022789786,-0.060284045,-0.06665958,-0.0024502652,0.013293209,0.01619992,0.03622847,-0.04568475,-0.05579369,0.10471196,-0.085263886,-0.033658545,-0.07354823,0.04627588,-0.050875697,0.03768179,-0.032400113,0.032402296,-0.10128203,0.014968943,-0.061405838,0.068929836,-0.019108638,-0.062255982,0.013213776,0.04647417,-0.09220532,-0.0048885145,0.029003544,0.026520854,0.020255167,-0.042679057,-0.083074905,0.020429105,0.013079676,-0.023298707,-0.0072009363,-0.02409883,0.048961584,-0.04382238,0.041176558,0.0027111769,-0.021752467,0.014934415,0.009463489,0.025724418,0.03436243,0.058472514,-0.023646347,-0.051254332,-0.14703552,-0.085370705,-0.07093666,-0.09886578,-0.048663586,-0.05833196,-0.010448587,-0.07777202,0.0017106391,-0.017895076,0.16089211,-0.013029648 +3.2.1.108,"The enzyme from intestinal mucosa contains two glycosyl hydrolase domains, both of which belong to glycosyl hydrolase family 1 (GH1). While the first domain catalyses the activity described here, the second domain catalyses the reaction of EC 3.2.1.62 glycosylceramidase. cf. EC 3.2.1.33 amylo-alpha-1,6-glucosidase.",384,1.0,-0.00067162956,-0.09367134,-0.076178074,-0.03651578,0.0020232555,-0.07698347,-0.043996613,-0.038352653,0.037475966,-0.051423285,0.029546231,-0.05004265,-0.024530472,0.003508593,-0.03848688,-0.008531589,-0.05636548,-0.05950534,-0.0700954,-0.05760207,0.10943964,-0.0068600895,0.004636409,0.03135394,0.0011947353,-0.048011873,0.0741915,-0.021498926,-0.029870374,-0.076780796,0.010383089,-0.12091168,0.044672105,0.030243216,0.05205002,0.00034490216,-0.042187974,-0.06363513,-0.0009764324,0.00993491,-0.013576883,-0.059527803,0.046984535,-0.090653755,-0.06777058,-0.05647539,-0.003123197,0.014123212,0.04950717,0.02100338,0.017816639,-0.07370893,-0.073110424,0.0033508055,0.046786163,0.022394542,-0.061614428,0.036074713,0.01322978,0.05638454,0.032594595,0.02103706,-0.027455876,0.03598972,-0.06809103,-0.10816624,0.11318954,-0.06934752,-0.0883,-0.0254989,-0.118035786,-0.070549846,-0.020221177,-0.03633233,0.084836975,0.045532394,-0.043509483,-0.011810189,0.018417435,0.005331211,0.07713456,-0.024834208,0.06375952,0.08938754,-0.04323767,-0.023316551,-0.0036521917,-0.004644727,0.063744165,-0.03944758,0.062092606,-0.15147546,0.0077033285,0.0009711169,0.050422035,0.06411352,-0.016813952,-0.025476092,0.013334493,-0.028435927,-0.11294216,0.04935442,0.0535372,-0.07522601,-0.027608652,0.1236613,-0.023034351,0.15441924,0.06065759,-0.030857233,-0.026396673,0.040400907,0.06832159,0.034925863,-0.02073185,0.006715533,0.044719227,-0.044842713,0.02380459,-0.030130526,0.052257456,-0.007907531,0.073504224,0.013463531,-0.034531064,0.033022292,-0.036934637,2.3161796e-33,0.041805375,0.032175098,0.0059248125,-0.059286166,0.0058878786,-0.011211759,-0.038902596,0.0053054527,-0.061974775,0.056217685,-0.02339194,0.01819964,0.025830867,0.07733679,-0.001418544,0.07892807,0.018385336,-0.016228607,0.038453817,0.048576757,-0.010374777,0.09426967,-0.01072487,-0.040735845,0.07602376,0.078424156,-0.03462953,0.038896143,0.010436384,-0.0047790916,-0.049674835,-0.06794652,-0.10626879,0.07249053,-0.0015798409,0.04101829,0.02000547,-0.010419305,0.04521055,-0.0036711951,0.014451526,-0.018913329,0.0017501845,-0.05222934,0.01432287,-0.03201289,-0.037780013,0.07971429,0.04045441,0.12245524,0.063158646,-0.02885603,0.09096903,-0.0057882364,-0.011422859,0.036816586,0.020277616,0.036637973,0.04649037,0.040710162,-0.041028056,0.06797849,-0.009121113,-0.021836549,-0.021404644,0.011517839,-0.10638288,-0.031992327,-0.036206793,0.08669093,-0.08100246,0.015638517,0.032634944,-0.0014749139,0.04395196,-0.11123603,-0.0113639105,0.04159168,-0.0064150156,0.041861996,-0.013053156,0.016925303,0.031712405,0.041472808,-0.03252964,0.08116986,-0.05454505,-0.03181351,-0.050743803,0.0629507,-0.054662444,0.015761549,-0.0030366094,0.06751834,0.032943625,-4.206405e-33,0.104939684,-0.09048736,0.024719438,-0.07810015,-0.016135726,0.014750319,0.05846247,-0.004729347,-0.010984636,-0.02714218,0.040213488,0.06484403,-0.030373748,-0.075615615,0.085144505,-0.028050868,0.013826129,0.03098742,-0.028786836,-0.034874108,0.023552839,0.07060987,-0.041424483,0.006006172,0.0556925,-0.019267714,0.035605352,0.08547054,-0.024692392,0.018905073,-0.069863334,-0.028713172,0.018324994,-0.020916931,-0.024436364,0.024641464,-0.06981778,-0.025986128,0.013106881,0.003995027,-0.014467548,0.043647487,0.027398102,0.108711265,0.07046223,0.117960505,-0.050847,0.011083391,-0.0211726,-0.05763364,-0.032728326,0.025737397,0.023383567,-0.0067288773,0.05636729,0.059792545,0.0449767,-0.04445121,0.016366372,-0.021839973,-0.030436233,0.04715014,0.013999966,0.027586767,0.07504709,0.065607116,-0.09440249,-0.0056170775,-0.023510795,0.06481911,0.08356281,-0.06436265,-0.044606943,-0.012209704,0.06620355,-0.019809969,-0.1295351,-0.010863844,0.010236517,0.012327681,0.069092415,0.020625448,0.007914464,-0.040359776,0.03654471,-0.055712294,0.025741646,0.109246865,0.010244483,0.018731121,0.006889868,0.03080196,-0.010220758,-0.019793095,0.04859221,-3.7744755e-08,0.038473565,-0.1031175,-0.02417156,-0.0700543,-0.04234702,0.030514063,-0.043132603,0.03502274,-0.00900797,-0.0031636427,-0.042586353,0.08917297,-0.002663214,0.045267824,-0.0472489,-0.00043341675,-0.031505108,0.011004094,-0.019409066,-0.0008386748,-0.053404596,0.01697507,-0.07628964,-0.016387235,0.026050612,-0.06180707,0.018101923,0.037408423,-0.1006844,0.041061528,-0.02976008,0.017192317,-0.044218384,0.01534454,-0.03246266,-0.042345,0.027221631,0.0057788854,-0.016800785,-0.07608931,0.026098534,-0.06620794,0.0074619185,-0.053141832,-0.025209596,0.05855994,0.031004937,0.010465943,0.059319552,0.0012191497,-0.030154722,-0.023404421,-0.031691592,-0.028927661,-0.06636106,-0.09099817,-0.042152185,-0.07968682,0.028331239,-0.062211517,0.011874389,0.038471904,0.17676276,-0.04374524 +3.2.1.111,"Not identical with EC 3.2.1.63 1,2-alpha-L-fucosidase.",384,1.0,-0.006755787,-0.05135432,-0.08832114,0.005841629,0.06955398,-0.09614279,-0.05489878,0.051356014,0.10411973,-0.06284712,0.10264871,-0.07892915,-0.07538603,0.01099131,-0.041216698,-0.07297795,-0.03041542,-0.07610977,-0.041444775,0.010277352,0.02872979,-0.017234458,0.017264742,0.013656175,0.008551047,-0.028292626,-0.015308838,0.026826173,0.004873897,-0.12836456,0.01892871,-0.008982178,0.043290667,-0.037268702,0.040664297,-0.03544222,-0.028284824,-0.08686803,0.014130724,0.027895343,-0.03254718,-0.015851036,0.051776472,-0.027315445,-0.044671077,-0.0054230033,-0.07665056,0.059458684,-0.010479619,0.044883415,0.010326513,-0.06874686,-0.07285081,-0.022017961,0.017775139,0.05426597,-0.08823427,0.009339078,-0.042912822,0.120224796,0.032952882,0.08891385,-0.033862986,0.026795318,-0.025323989,-0.03134767,0.056666635,-0.15157159,-0.017877385,0.031177102,-0.060464807,-0.03629816,0.062069595,0.02466384,0.097558,0.16674271,0.035923608,0.010313974,-0.033545673,-0.049676463,0.0050140843,-0.025886841,-0.025124364,0.03979602,-0.0024921582,-0.04604458,-0.039050523,-0.06325369,-0.0014022029,0.028568633,0.08569531,-0.02649071,-0.008940663,0.04481653,0.014401836,0.08160072,0.009339856,0.13644412,0.0042150356,-0.010037061,-0.088702284,0.052831277,-0.018333124,-0.07001424,-0.0015852053,0.036054622,0.009180143,0.029931905,0.039124556,-0.043257184,-6.639729e-05,-0.0150505295,0.081699036,-0.027225057,-0.0056497203,0.0176523,0.056660827,-0.022638675,0.031070178,0.052725002,0.07846664,-0.042642336,0.053444814,0.047098096,-0.06514675,-0.01156039,-0.0013826177,-2.5197304e-33,0.012490378,0.08222306,0.056087233,-0.0014905146,0.0004800948,-0.04314763,-0.067614436,-0.072219685,-0.08733468,0.04394713,-0.100371554,0.02678602,-0.0026700196,0.0033617993,-0.049555942,-0.03707582,0.009222468,0.001981553,-0.035691418,-0.008555443,0.09667546,0.052613426,0.008902023,-0.045347665,0.064759016,0.03745866,-0.044609554,0.02018312,0.03364876,0.012884517,-0.012299127,-0.06379785,-0.024312714,0.022085277,-0.04102351,0.04959855,-0.015874516,-0.06833495,-0.030919012,-0.020677982,0.05704154,0.08758892,0.029585741,-0.047878075,0.033419948,-0.066384844,-0.058894597,0.0476861,0.103501596,0.028236022,0.0037523927,-0.010173681,0.09661133,0.0104409885,0.044857595,-0.072080255,0.001124588,0.076644674,0.016745653,0.09735396,0.02098972,0.14568949,-0.053691186,0.00608683,-0.02988243,0.048532408,-0.08306144,-0.027149735,-0.013442678,0.006211495,-0.019658957,0.012336611,0.08646556,-0.052177794,0.10849747,-0.10767504,-0.083459936,0.013411002,-0.026735695,-0.01508029,-0.025030399,-0.023266634,0.0069448906,0.01890657,-0.10693353,0.016164163,-0.01084299,0.05173675,0.028719945,0.055516828,0.03327259,-0.006407454,-0.0017225866,0.053971708,0.0108759925,1.359453e-33,-0.0704441,-0.025905529,0.010994433,-0.024364261,-0.011906671,0.06854731,0.02407753,0.058120206,-0.003434152,-0.045414705,0.14086306,-0.040380266,-0.045766085,-0.10029469,0.01462139,0.0027745063,0.00037556037,0.01339728,0.03138671,0.048162103,-0.04033958,0.08671235,0.02318366,0.07016787,0.08057012,0.01594076,0.05648824,0.044423994,0.0031682148,0.016708724,-0.017439589,0.049369503,-0.01113663,-0.058617033,-0.05643395,-0.040649366,-0.021763023,-0.032654367,0.04667246,-0.053117,-0.027567875,0.036091935,0.028254211,0.035719372,0.0892213,0.14211859,0.012367212,-0.05510393,0.05519982,0.02467207,-0.030553155,-0.03895845,-0.07073041,0.073151685,0.010934084,0.02222325,-0.013579755,0.024238948,-0.039957967,0.0031910853,-0.048005197,-0.018985817,-0.022753945,-0.043012023,0.109580345,0.02923012,-0.08180952,0.07349882,0.07397927,0.030458413,0.029520528,-0.025802862,-0.05754386,-0.050944194,0.034310367,-0.049168225,-0.043127812,-0.004444434,0.0129927,0.0056549665,-0.032778017,0.042768974,0.004166328,0.0073197843,0.032398827,-0.047670063,-0.0038486256,0.051938698,-0.04294156,0.060260788,-0.03621201,0.02093508,-0.07904571,0.005819758,0.09691848,-2.3685608e-08,0.119003825,-0.037826862,-0.023256484,0.010502683,0.026784135,0.004993617,-0.052642003,0.010864667,-0.010629286,0.040938307,-0.07849341,0.12408049,0.036324643,-0.022025675,-0.015599413,-0.027425654,-0.050867755,0.048890267,0.016415583,-0.0020812773,-0.02966204,0.046984855,-0.05228511,-0.068711944,0.008688703,-0.014170008,-0.058943085,-0.0131367585,-0.048091367,-0.022850852,0.015390349,-0.012515705,0.021060448,-0.036353637,-0.08811171,0.0035861337,-0.06331401,0.021313861,-0.084437825,0.044880465,0.029672917,-0.03716374,-0.027239561,0.008039549,0.00016814057,0.0036216716,0.013745988,0.030646104,-0.00059100613,-0.066710636,0.011713176,-0.039907854,-0.030080343,-0.036126077,-0.01814558,-0.05429237,-0.021845123,0.0026008587,0.06998718,-0.061331376,0.006184211,-0.0809006,0.11788734,0.016515682 +3.2.1.113,"This family of mammalian enzymes, located in the Golgi system, participates in the maturation process of N-glycans that leads to formation of hybrid and complex structures. The enzymes catalyse the hydrolysis of the four (1->2)-linked alpha-D-mannose residues from the Man9GlcNAc2 oligosaccharide attached to target proteins as described in reaction (1). Alternatively, the enzymes act on the Man8GlcNAc2 isomer formed by EC 3.2.1.209, endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase, as described in reaction (2). The enzymes are type II membrane proteins, require Ca2+, and use an inverting mechanism. While all three human enzymes can catalyse the reactions listed here, some of the enzymes can additionally catalyse hydrolysis in an alternative order, generating additional isomeric intermediates, although the final product is the same. The names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7].",384,1.0,-0.007435725,-0.08097123,-0.061420843,-0.054883067,-0.021884127,-0.0077544823,-0.010251801,-0.0026641549,0.035264716,0.06961712,0.012567193,-0.0004554984,-0.12303092,0.050065737,-0.04866885,-0.065911226,-0.08971219,-0.009146016,0.02608717,-0.06433061,0.1222945,0.0063633635,-0.024623806,-0.02391022,-0.006103036,-0.04678978,0.0022580824,-0.024590464,0.029275933,-0.10995502,0.014800892,-0.14154997,0.0089061605,-0.048996106,0.03228586,0.068340234,0.0035099906,-0.008030699,-0.0072608753,-0.04019609,0.0157779,-0.07231867,-0.017499624,0.0015637118,-0.05927696,-0.003936842,-0.043564793,-0.008145649,0.022184633,0.060480878,-0.0014567755,-0.051575247,-0.055076826,0.027328718,0.062460363,0.0037914286,-0.07557413,0.02115381,0.08590829,0.04976465,0.016890215,0.008879696,0.042353317,-0.045063127,0.02368845,-0.054446466,0.039781395,-0.075280584,0.019446839,0.022654079,0.004402411,-0.026828378,-0.036774058,-0.03395241,-0.008162507,0.027834686,-0.08181259,0.0046974225,0.012966804,0.011209249,0.06955575,0.04664977,0.08616869,0.08453927,-0.043485086,0.0035902865,-0.06257639,0.05238379,0.1084036,0.005097739,0.017009508,-0.007848456,0.08459796,0.016710741,0.032429542,0.0012377416,0.02291946,0.06331856,0.030517142,-0.044813067,0.039137825,0.017905936,0.024923718,-0.11983636,0.0087915985,0.072415665,-0.038965356,0.07528627,0.0345828,0.015985735,-0.034100454,0.07382039,-0.0036213251,-0.038869116,-0.086227916,0.033203904,0.010686405,-0.058614835,0.002435464,-0.040017307,-0.002279779,0.0193896,0.055977408,0.054384403,-0.0040954184,0.03617758,-0.08547473,1.3052913e-33,0.0026738655,6.616612e-05,0.025849508,0.03175857,-0.014620026,-0.017157711,-0.037751276,-0.0062195845,-0.04074672,-0.008656464,-0.065477595,-0.01662653,-0.049866244,0.095680445,-0.031148864,0.04549441,0.0040938584,-0.039761562,-0.013016635,-0.0068777376,-0.011584562,0.12530747,0.01580509,-0.013332774,0.1216881,0.033183876,-0.066752546,0.007872943,0.0715681,-0.045189008,0.06158906,-0.09613316,-0.09605395,0.042934053,0.056196444,0.036663163,-0.015109974,0.013941779,0.03169625,0.062760994,0.019250203,0.003239727,-0.03819974,-0.05957174,0.0825896,-0.011602415,0.02821045,0.065445706,0.00589405,0.0054125884,0.04349598,-0.005429581,-0.0074276105,0.0269054,-0.099871635,-0.019973205,-0.011014595,-0.010075425,0.0062448634,0.09970535,0.038086984,0.03114768,0.02990047,0.0033392936,-0.0019623605,-0.021113526,-0.04724213,0.00733287,-0.018519603,0.051123794,-0.05381383,-0.032071438,0.11744378,-0.0024595123,0.039766077,-0.06298518,-0.04108486,0.03542251,-0.004829639,0.0041835317,0.038536727,0.009354843,-0.0015408586,0.018406117,-0.081472315,0.0050089005,-0.020861508,-0.09454119,-0.06438031,0.039513454,0.023769088,-0.03268513,-0.08210461,0.09737792,-0.053083602,-4.432601e-33,0.10522204,-0.094827175,0.070565216,-0.09859679,-0.07712738,0.02786778,0.07130164,-0.04593122,-0.0005342572,-0.055767607,0.03447071,-0.0012944919,0.0644907,-0.0013751925,0.016166711,-0.060071897,-0.049000073,0.08475656,-0.0131096225,-0.015227611,-0.043861173,0.10910319,-0.022467718,0.013015976,0.086582266,-0.0060697324,0.07268956,0.047096327,0.046799723,0.067991994,-0.047163863,-0.020595118,-0.036702517,-0.022904035,0.01817282,-0.02191627,-0.046316877,0.035803206,0.010552842,-0.024951983,-0.031732723,0.046268303,0.021460328,-0.03776084,-0.0025744026,0.09244994,-0.062042955,0.04624267,-0.11821926,-0.02135789,0.02377675,-0.03489328,-0.09511764,0.040906835,0.039708115,0.057682537,0.036489718,-0.019779509,0.022502417,-0.003637525,-0.045831945,-0.023990804,0.069813296,-0.043458562,0.02437265,0.050403617,-0.05176019,-0.0122669265,-0.02674757,-0.0014585106,0.008033506,-0.06304381,-0.014728102,0.002563074,0.011634897,0.0041787126,-0.07825827,-0.07058143,0.011098384,-0.09792222,-0.026767181,-0.009308359,0.04448844,-0.0076589617,0.060023777,-0.023352034,0.06773441,0.16539563,0.038927183,0.10782547,0.019718451,-0.030057957,-0.0672762,0.10506347,0.04577729,-4.7250506e-08,0.019527348,-0.00827567,0.004591585,-0.11047353,-0.055710696,0.029143967,0.023396498,0.01669784,0.010761915,0.004590946,-0.02859201,0.047249213,0.016798213,0.011918322,-0.017011875,0.038558207,-0.052629344,0.043422434,-0.022192072,-0.042147215,-0.1415067,-0.02789441,-0.09931319,0.04821382,-0.0048407777,-0.03986379,0.05406351,0.0933338,-0.03756196,-0.029272575,0.009128788,0.033695366,-0.006017797,-0.09762867,0.0064399717,0.03313022,-0.0093835555,-0.026382139,0.023131086,-0.027509045,0.0086767785,-0.056839578,0.025620656,-0.024271455,0.016036345,0.006153119,-0.021715738,0.042183515,0.0021439537,0.12455908,0.04760597,0.0024850476,-0.042788807,-0.08959189,-0.09927815,-0.06869856,-0.082375415,0.00042106287,-0.016072873,-0.061416212,0.027231103,-0.03095292,0.1379431,-0.06965774 +3.2.1.114,"The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine.",384,1.0,-0.039603185,-0.0070022577,-0.06504176,0.0071408856,0.060721748,0.02388455,-0.007258108,-0.015505333,0.034978125,-0.024677498,0.08353248,0.083129756,-0.064184494,0.008508644,-0.122829065,-0.036400188,-0.051005196,0.00039606064,-0.021464169,-0.08341688,0.09859246,0.007069929,-0.004751166,-0.0064185304,0.022877628,-0.04167,-0.014963441,-0.024133326,0.07409879,-0.07237095,0.00505027,-0.017485268,0.0026661037,-0.0035138007,0.023616472,0.08186226,0.04070466,-0.03700973,0.03351241,0.024840673,0.04296035,-0.08233541,-0.020687759,-0.058949865,-0.031913996,0.02024095,-0.055493608,0.006629864,0.0010352659,0.020278368,-0.030222451,-0.05534501,-0.03278508,-0.020983312,0.018369853,0.055692863,-0.032811783,-0.005758727,-0.00068390014,0.060880695,0.078061715,-0.026295125,0.009564956,-0.027450476,0.033463825,-0.0754286,-0.0022265846,-0.07348062,0.017055346,0.01061876,0.015031463,-0.046328004,-0.019897759,-0.047825187,-0.03686911,0.029931284,-0.07030582,0.019503014,0.05298472,-0.0041900496,0.0744248,-0.0035728463,0.10190693,0.09540485,-0.04056962,0.021984773,-0.048027664,0.039156478,0.060787182,0.003289378,0.09020379,-0.03438173,0.013460957,-0.0035686167,-0.017172083,0.027999392,0.003655757,-0.013467755,-0.0045513688,0.00902322,-0.0023909518,-0.012055269,0.05660342,-0.09016782,-0.115479186,0.06956822,-0.06409362,0.01890887,0.06017455,-0.02227805,-0.05672641,0.09273844,0.03661768,0.05714549,-0.062408496,0.05851468,0.10983169,-0.02226164,-0.067043915,-0.037627522,0.012310523,0.0030756372,0.024061223,0.100832276,0.016673978,0.05715128,-0.086230956,-8.497473e-34,0.06552613,0.021036591,-0.04893126,-0.052913643,0.012253854,0.009915521,-0.02340714,-0.015753068,-0.06065628,-0.0037503238,-0.06269494,-0.014643368,-0.019239534,0.093638964,-0.0107541,0.07134973,-0.014329309,-0.030356942,0.048905738,-0.045407888,0.04582887,0.028053727,-0.019139383,0.011304387,0.040889643,0.07663895,-0.06540404,-0.044253714,0.037994307,-0.03139973,0.05847967,-0.09854863,-0.092566915,0.055215843,0.053213563,0.03888643,-0.033166543,-0.06139349,-0.010807086,0.040200494,0.026857091,0.016479552,0.0051400657,-0.0065582506,0.04940702,-0.02601158,-0.018986428,0.082735665,0.01550357,0.07522899,0.055548757,-0.005882312,0.06056282,0.00030069452,-0.087389044,0.04049314,-0.044063658,-0.02070393,-0.0106725665,0.05034806,0.04151055,-0.0058542257,0.00066805206,-0.005399365,0.04333331,0.073341645,-0.054756936,-0.026970632,0.0025934214,0.05994445,-0.052115455,-0.025239157,0.06436147,0.0052881977,-0.074306846,-0.063792594,-0.03771055,0.022550099,0.0039499463,0.028506633,-0.023071416,-0.011543248,-0.009421474,-0.032662492,-0.0886544,0.021583274,-0.027072838,-0.13193703,-0.012910412,-0.026783539,0.097334534,-0.037525106,-0.118654355,0.03174913,-0.047878165,-1.2488307e-33,0.10019468,-0.12183884,0.07880114,-0.0036453542,-0.08680151,0.022565747,0.027338631,-0.044332977,0.030739155,-0.021428661,0.021781396,0.00092981773,0.019258782,-0.033514686,0.05369432,0.021731528,-0.008755605,0.11613463,-0.027435217,-0.035420164,-0.058129787,0.108911045,0.034580745,0.023861567,0.039125096,0.008629778,0.023022322,-0.0051603536,0.0017636967,0.028490735,-0.022792462,-0.022489438,-0.028126633,-0.097501956,0.041191112,0.009334176,-0.07799931,0.051594637,0.033662822,-0.037517563,0.03803026,0.043967854,0.032896075,0.05585988,0.02821776,0.13088024,-0.12248026,0.046290882,-0.061121237,-0.014090199,0.026985724,0.028429251,-0.024395112,0.01077961,0.05304256,0.056491453,0.037735704,-0.033231508,-0.1068882,0.018812127,-0.017066384,-0.010653126,-0.0625075,0.040998492,0.06193676,0.057979308,-0.04291747,0.04390312,0.068659484,0.006600767,0.043928646,0.0018687894,0.040199652,0.013128099,-0.063618444,0.036152057,-0.10527358,-0.046680696,-0.01630822,-0.06452506,-0.02972562,0.0108144665,0.010345518,-0.055857528,0.036505785,-0.0440391,0.041899092,0.16523115,0.07081009,0.038180806,-0.012609045,-0.03015268,-0.064047545,0.026955653,0.062968075,-3.6542236e-08,0.04090396,-0.047007497,0.007720165,-0.10537574,-0.019312968,0.039430875,0.013875307,0.098849066,0.0027552892,0.021905195,-0.05929042,0.041218054,-0.06623163,-0.003079569,0.007994282,0.03417423,-0.016389696,0.039542265,-0.050441373,-0.08972724,-0.115214586,-0.005738784,-0.069372095,0.086615816,0.018449634,-0.068497844,0.042065132,0.1270369,-0.047827683,-0.036303807,0.019824058,0.025468713,-0.007985464,-0.0114076715,-0.033443354,0.06712257,-0.019527724,-0.033898316,0.01391617,-0.0069535193,-0.04471319,0.01812886,-0.02152118,-0.04501276,-0.05790448,-0.013014945,0.032418597,-0.06234967,0.035117824,0.09903961,0.009937656,0.030648503,-0.036088727,-0.05366114,-0.12744404,-0.05590465,-0.011896495,-0.0344969,0.026517615,-0.04786621,-0.00018980356,0.0073208525,0.13527265,-0.0640123 +3.2.1.115,Has a much lower activity with kojibiose and kojitriose.,384,1.0,0.021597188,-0.065196805,-0.0043274197,0.07780425,0.014456209,0.04470834,-0.05024829,0.081956066,0.016990403,-0.055119958,-0.01639252,-0.0002932687,0.00841981,0.11838577,0.05653122,0.040196005,0.03714102,0.03261196,-0.010981863,0.015710255,-0.014876904,-0.025756435,0.093570165,0.0019009486,0.01926396,0.018429989,0.025601963,-0.018055363,0.0003358237,0.00426769,0.008356286,0.081947036,0.021108292,-0.085309826,-0.049578115,-0.0075078453,-0.017224487,0.001715657,0.064536944,0.017060077,-0.028307652,0.034846965,-0.0034230875,0.0022772888,0.008047064,-0.004176943,-0.041125536,-0.01807678,0.043732144,-0.007925029,-0.07077865,-0.107520975,0.05739057,0.0054712873,0.022739379,-0.009726091,-0.12634914,0.004529193,0.04218698,0.081380114,-0.010249806,0.034393173,-0.005979295,0.07677391,-0.0053223036,-0.04025201,0.0182454,0.02505587,0.0498995,0.011695388,0.0032904893,0.010033019,0.04191006,0.08689673,-0.04281554,-0.04330162,-0.0036654477,-0.02495807,-0.057754982,-0.03136053,-0.02622162,0.005643134,-0.017037665,0.07811522,0.04093105,-0.02076577,0.0060566003,-0.02673882,-0.018758865,0.1041497,0.045012865,0.022639688,0.01630389,-0.023792882,-0.035850715,-0.043502435,-0.018174212,0.073372275,-0.12881494,0.014038522,-0.027709896,0.034635946,0.020352291,-0.043228004,0.0031334127,-0.0071279528,0.046019737,-0.04675722,-0.055018105,0.056400694,0.042772718,-0.042119827,0.0023076362,-0.017848235,-0.06782781,0.09122837,0.07732029,0.00034484323,-0.10973063,0.08731376,0.03583632,-0.072849706,0.0381268,-0.038425468,-0.0122110015,0.030349301,-0.02711157,-5.670528e-35,0.0150593985,-0.039578974,0.056596782,-0.009619498,0.0107686,-0.044810276,-0.07893493,-0.04700946,-0.0036074265,-0.036869284,-0.067984655,0.026740711,-0.026459806,0.026083255,0.038317222,-0.033962358,-0.072297804,0.014478071,0.096611924,0.029322354,0.047001824,0.0033189591,-0.04130001,0.056517113,-0.048378456,0.020624742,0.085500315,-0.02395018,-0.07492003,0.0063721263,-0.02040926,-0.06096038,-0.068846904,-0.001747612,-0.09090768,0.05422215,0.02635611,-0.02456204,-0.03410649,-0.0089073125,-0.012308255,0.030401215,-0.078717746,-0.020984448,0.02792448,-0.08498451,-0.051721912,-0.017969174,-0.012145537,0.08168552,0.0007472031,-0.00061388884,0.07785204,0.053520042,-0.06520236,0.033047955,0.05976327,-0.058693964,0.0055869697,0.028313331,-0.01342395,0.029490931,-0.043428585,0.039916728,0.005699037,-0.030002829,-0.04504694,-0.09204636,-0.107593864,0.01630024,-0.058068022,0.00080095365,0.07639856,0.015632391,0.023287099,-0.07857399,-0.081119284,-0.024892868,-0.033798903,0.0018912634,0.05181071,-0.06339788,0.062045824,0.07148047,-0.0063182297,0.057903085,-0.034027774,0.054819748,-0.02890605,-0.001539784,0.02758453,-0.06641173,-0.047412388,0.04110739,0.018740414,-7.0130943e-34,-0.025071876,-0.011701156,0.0542725,0.040999036,-0.040096473,0.09657883,0.041259956,0.06206555,-0.027118659,-0.051435415,0.07299866,-0.019708099,-0.051685743,-0.0050297454,0.03551238,0.032297622,0.008850059,0.08573491,-0.035349485,-0.042096,-0.004313525,0.10401139,0.004967831,0.00841246,0.005241721,0.07130085,0.027521547,0.02319227,-0.07346795,0.12700069,0.052928977,0.016901681,-0.0817517,-0.07351182,-0.0066735223,0.01506343,-0.076048896,-0.0010261965,-0.07549773,-0.023116754,0.0020884916,0.043441765,0.058222815,0.05425894,0.044363152,0.044541508,-0.07001757,-0.0415249,0.042421065,-0.0034557765,0.027495332,0.033349425,-0.05800602,-0.024158673,0.07480689,-0.040748723,-0.034713224,-0.07333381,-0.067954466,-0.020084864,-0.03326302,0.014977274,-0.015120009,0.021073675,0.11047749,0.052945875,0.0025262346,0.1315392,0.033536017,-0.051894594,-0.013611312,-0.0723171,0.010269584,0.003830325,-0.0038322196,0.051789418,-0.053215716,0.034865774,0.012142766,0.07137718,-0.030134238,-0.04081932,-0.0019768928,-0.060686488,-0.022535488,0.058241535,-0.10477625,0.0056390213,0.07384702,0.032306097,-0.018746039,-0.011122196,-0.053129844,-0.07995217,-0.0022046126,-1.9773346e-08,0.046528947,-0.13090865,0.029416118,0.011390395,-0.01906361,-0.00096462347,-0.03859381,0.0475457,0.018688718,-0.010089962,0.092440546,0.08113222,0.0026804544,0.09917987,0.054865163,-0.047254756,0.00023779912,0.08134356,-0.02146579,-0.005298102,-0.088051654,-0.04126799,0.05684725,-0.012043721,0.0028642707,-0.033167813,-0.030230243,0.09641994,0.049294442,-0.033603627,-0.014537334,-0.03341426,-0.06635886,0.055662394,-0.09378316,-0.0067810314,0.006453535,0.03480458,-0.08335408,0.07069547,-0.0950457,-0.12873451,-0.06433622,0.05471702,-0.015134069,-0.006586552,0.06378144,0.053289164,0.061395656,-0.18076248,-0.024721198,0.012216668,0.04038085,-0.046827644,-0.11778885,0.09118846,-0.020909758,-0.04628973,-0.02061504,-0.106633745,0.0148332715,-0.05551224,0.010533785,0.06800995 +3.2.1.220,"The enzyme, isolated from the roots of the plant Carapichea ipecacuanha, preferentially hydrolyses glucosidic ipecoside alkaloids except for their lactams, but shows poor or no activity toward other substrates. IpeGlu1 activity is extremely poor toward 7-O-methyl and 6,7-O,O-dimethyl derivatives. However, 6-O-methyl derivatives are hydrolysed as efficiently as non-methylated substrates. IpeGlu1 accepts both 1alpha(S)-N-deacetylisoipecoside and 1beta(R)-N-deacetylipecoside epimers as substrate, with preference for the 1beta(R)-epimer. 6-O-methyl-N-deacetylisoipecoside is an intermediate in the biosynthesis of the medicinal alkaloid emetine.",384,0.99999994,-0.013055306,-0.06897008,-0.030975116,0.013164744,0.0023365556,0.010675719,-0.08703341,0.057444595,0.096354604,-0.059481032,0.0501568,-0.025815077,-0.07274883,-0.060610108,-0.041999437,0.050869446,-0.0018331826,0.060485356,-0.06336531,-0.02368239,0.014074873,0.006694607,0.050734848,0.024178114,0.064128816,0.027311789,-0.00018032217,0.03611435,0.03255932,-0.1005195,0.03822096,-0.059174214,0.0375531,-0.00910169,-0.031618506,0.056100618,-0.006053354,-0.013152034,0.05698201,-0.020548096,0.066041626,-0.017941792,-0.017112423,-0.026655065,-0.07286062,-0.13457105,0.011319706,0.049635667,0.0003927953,0.0126184365,0.07449679,-0.043159127,-0.023421086,0.030955281,0.020343572,-0.066211246,-0.053457078,0.025118366,-0.034296773,0.091730565,0.04114546,0.051056866,-0.01975804,-0.0115798265,-0.08646978,-0.079619564,0.012152584,-0.05017881,0.0071293903,-0.007639351,-0.054761633,-0.050667636,-0.011497001,0.05180291,-0.01945626,0.1185236,0.0062180646,-0.012966376,0.02407849,-0.05996977,0.06496346,0.033118404,0.027547618,0.084653355,-0.016520757,-0.018068872,0.023252457,0.082869545,0.08265065,-0.028611286,0.105816334,0.00703643,-0.04239685,-0.061588164,0.023451118,0.054836042,-0.029854737,-0.010157416,-0.10082245,0.031299893,-0.02564801,0.0017210582,-0.095743224,-0.052487396,-0.05651659,0.07089454,-0.019987466,-0.015031859,0.04452408,-0.02303941,-0.022415413,-0.03976443,-0.03815792,0.059129026,-0.077787496,0.046263408,0.0052602678,-0.0516342,0.027969835,-0.08441615,-0.07817957,-0.0605783,0.057936687,0.042190216,-0.03305796,-0.013293477,0.04346566,4.7127273e-33,0.024343524,-0.03206612,-0.0025420005,-0.07839078,0.105572425,-0.019305138,-0.00016849974,-0.00567894,-0.002542502,-0.018810337,-0.10004895,-0.038735542,0.025064463,0.053510945,0.09782121,0.0108515015,-0.006882825,0.020694094,0.079771794,-0.037430342,-0.00771057,-0.011811437,-0.1046058,-0.01228172,-0.08436305,0.06968043,-0.011387248,0.022597784,0.04010002,-0.031656243,0.0066763507,-0.025877183,-0.054631203,0.05696215,-0.025631474,0.037671857,0.008514482,0.012534979,0.055438105,0.03369069,-0.009984625,0.0533097,-0.0172162,-0.0041116714,0.046932008,-0.00097001356,-0.056984697,0.039480004,-0.010700193,0.05573876,0.041434903,-0.009013358,0.051526148,0.029262425,-0.0140865045,0.006955676,-0.0790526,0.06283816,0.10160651,0.058585387,-0.03758976,0.031298526,0.015768887,-0.0012731694,0.008297325,0.042595275,-0.03442938,-0.0495948,-0.037427574,0.06360924,-0.021547545,-0.030723488,-0.018694645,0.054910652,0.02054965,-0.035272285,-0.006862904,0.025701476,0.018646061,0.04183009,-0.00071747525,0.01665042,0.026787685,0.01965955,-0.062220987,-0.013749139,-0.05458829,0.007820942,0.018883478,0.05639265,0.026634797,0.04641256,-0.0663139,0.0725997,0.029524656,-5.5536e-33,0.105675936,-0.08478816,0.03049664,-0.06494145,-0.085037425,0.008911456,-0.0036128545,0.010176619,0.024819702,-0.03538887,0.021852603,-0.009534586,0.0060567185,0.008917864,-0.039103433,-0.049121223,-0.055593558,0.13463473,-0.026898023,0.06573999,-0.04410894,0.06984571,-0.05888624,0.10310154,0.058564864,-0.03169279,0.06033568,0.0060551018,-0.035983715,0.045039058,0.0038062593,0.017906059,-0.06956154,-0.047125593,-0.02852048,0.088823855,-0.023447292,-0.066769786,-0.004321785,0.09830725,-0.009398008,0.08371585,0.013049445,0.030697111,0.0614501,0.012120444,-0.07929538,0.05085499,-0.042795073,-0.08145527,0.01886464,0.04311825,0.034075,0.06321529,0.07948021,0.044695724,0.05610358,-0.07573547,0.04707482,-0.053797226,-0.030533824,-0.016730962,-0.029904354,-0.018186606,0.014379627,0.061217275,0.01816096,0.0396274,0.007535419,-0.032571945,0.057092674,-0.077684514,-0.014114271,0.034692917,0.021683365,0.0085531855,-0.022394352,-0.09379977,-0.032767884,-0.040759955,0.036281236,0.020577509,-0.020837449,-0.09823377,-0.035620254,0.016863566,0.021704113,0.11176055,0.008563223,0.086414225,0.052986078,-0.031984884,-0.03933387,0.14068781,0.079695076,-4.709621e-08,0.024210881,-0.084618926,0.04167381,-0.002042791,-0.062414963,0.03368301,-0.006378854,-0.007409409,0.031396195,-0.06597302,-0.01169472,0.08455284,-0.06253615,0.058741886,0.0048940512,-0.0018597418,0.085419394,0.04865996,0.0050824904,0.08086747,-0.11849172,-0.013427859,0.037907682,-0.11851241,0.03725963,-0.11474638,0.025888301,0.041649207,0.019596472,0.008680039,0.023307858,0.033258703,0.02793595,-0.04424533,0.035482865,0.050485503,-0.043958258,-0.05537401,-0.02158189,-0.03669745,-0.05887728,-0.0867256,0.02447474,-0.064867064,0.022061171,-0.009791208,0.007702587,-0.0091683185,-0.0008598667,-0.007892029,-0.0016370061,-0.08634971,0.047078982,-0.14129578,-0.04898206,-0.046472546,-0.09997928,-0.039213512,-0.03848585,-0.09653111,-0.0062412834,0.008300558,0.12891848,-0.053562306 +3.2.1.116,"cf. EC 3.2.1.2 (beta-amylase), EC 3.2.1.60 (glucan 1,4-alpha-maltotetraohydrolase) and EC 3.2.1.98 (glucan 1,4-alpha-maltohexaosidase). The products have the alpha-configuration.",384,0.99999994,0.028736303,-0.10885374,-0.0954508,-0.046317074,0.0032193332,-0.018802647,0.03535314,-0.00669566,0.03777122,-0.054772656,0.039611425,0.009178341,-0.07740543,0.0053879805,-0.048899103,0.0009198751,-0.055777967,-0.06329752,0.030692497,-0.028594341,0.034421753,0.0153472535,0.021822307,0.06644231,0.023241704,0.05236431,0.025988957,-0.013196217,-0.017434916,-0.1070155,-0.04424222,-0.09173905,0.068272606,0.03300441,0.01280769,-0.014197694,-0.08866195,-0.06671201,-0.061790347,0.061882973,0.025787579,-0.044440404,0.036947038,0.046614453,-0.10659061,-0.031913847,-0.114361286,-0.008089349,0.030754462,0.035038218,-0.03739181,-0.11171987,-0.098997,0.092032686,0.08701069,-0.020989154,-0.074753635,0.009870106,-0.024807468,0.108582035,0.036716733,0.060114402,-0.042088807,-0.016166478,-0.025880236,0.0146438,0.0360711,-0.115238816,-0.04499476,-0.015788041,-0.081719235,-0.06846295,-0.011327631,0.000876447,0.01025539,0.038621616,0.031392097,-0.026219908,0.05335894,-0.040094245,0.037241887,-0.016737396,0.030532787,0.1279057,-0.045544676,-0.039698344,-0.036968853,0.019881595,0.066250555,0.0075248983,0.072660275,-0.030525206,-0.02481565,-0.005504418,0.04523686,0.05545777,0.030910552,-0.03802009,0.050326932,-0.00895113,-0.015786467,-0.011202687,0.019952675,-0.06327232,-0.10307302,0.05707318,-0.008333819,0.053966526,0.032366797,0.017714366,-0.00920993,-0.035532963,0.024266532,-0.069686785,-0.07988497,0.005087029,0.0075156377,-0.010778733,0.06062523,-0.031528182,0.028729204,-0.0014923394,0.12700206,-0.015540866,-0.040892836,0.06580815,-0.111348085,-1.18074e-33,0.056363862,0.0067797923,-0.005970148,-0.012418076,-0.045677636,0.015905352,-0.08440453,-0.018593818,-0.05639666,-0.025466194,-0.07387092,-0.003642321,-0.060695067,0.047630917,0.052698165,0.02015201,0.036038283,-0.0007254945,0.008622328,0.030748544,0.012905405,0.12771365,-0.03848582,-0.00024928246,0.07483344,-0.0050702975,-0.04304443,0.016468072,-0.017195692,-0.002190274,0.0012981527,0.024811571,-0.13953814,0.047305133,-0.006130726,0.039839856,-0.06390777,-0.034928102,0.016406395,0.055803288,0.07459904,0.05450855,0.06371071,-0.036489252,0.0773288,-0.038023274,-0.007104411,0.08716989,0.06447961,0.024349602,0.008909624,0.024526177,0.027960243,0.011525091,-0.019800263,0.031464543,-0.03328199,0.057550248,0.077647306,0.039055366,-0.017190928,0.0725025,0.01423871,-0.07773782,0.0056503867,0.017231043,-0.05978288,-0.030265175,-0.07499085,0.034821175,-0.018583795,-0.014859782,0.0864039,-0.03736761,0.006377354,-0.059298337,-0.032372367,0.03065912,-0.052861445,-0.008351674,-0.020377157,0.03531972,0.038718354,0.072656624,-0.09270146,0.05200701,0.0073484625,0.031238444,-0.03820434,0.03037696,-0.0651282,-0.0016689104,0.0053931437,0.079289414,-0.044420734,-7.8117707e-35,0.10170813,-0.16630334,0.041572805,-0.04230005,0.019256659,0.057399254,0.07158193,-0.061742928,0.04362395,0.046718784,0.11804423,0.035122868,-0.054260075,-0.12597387,0.016160503,-0.022813292,-0.044376194,0.051604163,0.017131306,-0.008669221,0.0121937115,0.1196002,-0.0032279475,0.01813685,0.039300863,-0.094185576,0.08538501,0.052744187,-0.015960481,-0.04497162,-0.036885362,-0.016506389,0.03380929,0.00065446284,-0.080432095,0.02056113,-0.00837087,-0.045708776,-0.01652435,0.026245335,0.01163327,0.09111285,0.015921561,0.10138505,0.07858496,0.06270471,0.0012484555,-0.008140226,-0.013573987,0.0026344175,-0.0037264999,-0.053565297,-0.045331884,0.008647686,0.016811263,0.0386864,0.033632234,0.05566442,-0.013278069,-0.0034170528,-0.05279713,0.024937702,0.06933645,-0.04553688,0.054800007,0.07229978,-0.07776834,0.04651651,0.03122174,0.052470908,-0.0028898756,-0.061103016,0.00024843708,0.06273692,0.05169876,-0.01590364,-0.047938846,-0.0050015957,0.028704118,-0.033853266,0.03894393,0.039380435,-0.023755785,0.098446205,0.008992952,-0.0014521887,0.06695499,0.062340166,-0.025826612,0.025910307,-0.014510931,0.01052594,0.024895327,0.060917586,0.049470842,-3.4630435e-08,0.089147605,-0.012701533,-0.022102589,-0.05333814,0.040250525,-0.012628113,-0.011908576,0.043958038,0.014078668,-0.009075595,-0.042189676,0.08045124,0.0036858174,0.050423034,-0.008087003,-0.043909565,-0.027653031,0.009666856,-0.030790875,-0.0032006833,-0.06774546,0.031417195,-0.042361613,-0.018440833,-0.051600706,-0.09559519,0.04993466,0.00031810685,-0.06674158,0.024230996,-0.052782215,0.031164583,0.015335124,-0.11685369,-0.011773626,-0.0052739256,-0.035024457,-0.03200469,0.004585035,0.033168018,0.04774116,-0.10647517,0.034292735,-0.031119805,-0.02717565,-0.03354845,-0.009433389,-0.021009436,0.03835456,-0.014151738,0.038331002,0.018216437,-0.041412957,-0.06532816,-0.032042142,-0.04361827,-0.025349753,-0.046189126,0.03554283,-0.10727291,0.0702048,-0.019222714,0.14477709,0.018717755 +3.2.1.117,"Highly specific; does not act on prunasin, linamarin, gentiobiose or cellobiose (cf. EC 3.2.1.21 beta-glucosidase).",384,1.0,-0.03684308,-0.10016979,-0.14178391,-0.010438318,-0.02626549,0.05801366,-0.019990075,-0.0018732141,0.062457647,-0.0155293895,0.07668749,-0.018473433,-0.10967355,0.0669273,-0.056439023,-0.008703729,0.010606384,0.025248073,-0.06421407,0.018130584,0.025492288,0.007892193,-0.021358611,-0.026190469,0.009850712,-0.06223552,-0.008663311,0.017145878,0.0051144836,-0.050190467,-0.065749094,0.0020512121,0.043106884,-0.005513261,0.06242067,0.075751126,-0.101876445,-0.111277476,0.076801114,-0.021339701,0.07221403,-0.06194379,0.0033809757,0.024647145,0.024593187,-0.042604253,0.010963336,0.017304286,-0.013140738,0.03216733,-0.05193952,-0.12954581,0.020295566,0.07728989,0.03728832,-0.040353872,-0.07503133,0.016996535,0.07646606,0.055277407,0.0015450515,-0.0122012105,-0.042295177,-0.011069728,-0.066688016,-0.009307239,0.036156826,-0.071751215,-0.053981766,-0.07737208,0.026152357,-0.028082829,0.0049715326,0.0870253,0.034384962,0.11910314,-0.017519487,-0.033562664,-0.0669536,-0.04215205,0.021685889,0.042575166,0.064405754,0.060792398,0.009610719,-0.009240242,0.009775722,0.04831329,-0.033970624,0.016887072,0.0026426846,-0.05070114,0.023144774,0.011045048,-0.0657553,0.050470848,-0.0136229005,-0.0407759,0.017395651,-0.047627527,-0.06300606,0.04442939,0.053488698,-0.018518096,-0.054362863,0.059421737,-0.015558672,0.04503764,0.008145271,-0.052913647,-0.053440392,0.020790208,0.013950586,-0.030789271,-0.022327797,-0.011883482,0.06779364,-0.05151759,0.018004764,0.01660577,0.0035220876,-0.043650657,0.04034623,0.07611825,-0.060023583,0.039627276,-0.053480323,1.4876115e-33,0.022124996,-0.05693506,0.035091355,0.0021382063,0.036505956,-0.020637551,-0.08271636,-0.06078813,0.016378602,-0.009155722,-0.08509423,-0.019461574,0.03182709,0.11018423,0.011153002,0.055726107,0.011288517,-0.04746221,0.059571557,0.024798065,0.04209746,0.098396696,-0.08826315,-0.062252942,0.039135657,0.117173545,0.038539756,-0.008974084,0.012611805,-0.019778864,0.043457747,-0.05591318,-0.08779776,0.025134845,0.019094398,0.08038683,-0.087362714,-0.024030715,-0.020526854,0.03098463,0.013816808,0.043640994,-0.022537643,-0.01607035,0.12880889,-0.08824372,-0.03571246,0.021229267,0.021575598,0.0551226,0.07284694,0.02290575,0.038408693,0.02445639,-0.034223758,0.06916837,0.017619044,0.057569303,0.023424467,0.032252137,0.042487167,0.053075172,-0.041903794,-0.032514364,0.02528501,0.09658096,-0.13772336,-0.053486038,-0.03984787,-0.03315767,-0.038900174,0.036335777,0.03242591,-0.004026508,0.042277403,-0.038160555,-0.0009480913,0.054073,0.031211792,-0.049783655,-0.036736574,-0.0019206427,0.0093492465,0.02838831,-0.10556609,0.026780006,-0.0143445395,-0.003324001,-0.056408864,0.018036176,0.043281775,0.018032497,-0.12046396,0.021349784,-0.044022713,-2.662884e-33,0.06834239,-0.07850914,0.035104714,-0.056172036,0.002818356,0.037286818,-0.06991701,0.029373951,-0.0050859586,-0.05414578,0.09610077,-0.0072022076,-0.027856896,-0.007516647,-0.04020435,0.024053598,-0.0674478,0.008000265,-0.02698641,-0.035051044,-0.090795286,0.09710561,0.08509351,0.051643975,0.067891955,-0.03931762,0.041761376,0.06775937,0.0012386926,0.028060392,-0.07217287,0.038874403,-0.035577014,-0.028848292,-0.015406479,-0.003459226,-0.048033573,0.0040748576,0.06041812,-0.019011896,0.021458434,0.049997147,-0.038087383,0.08607364,0.057224587,0.15992698,0.018869352,-0.009269118,-0.0046286057,-0.016506935,-0.0049296655,0.019977758,0.012359843,-0.003551658,0.09440732,0.029861342,0.02685381,-0.05082201,0.0012695551,-0.0465676,-0.00025469207,0.008876621,0.035278954,-0.0037888868,0.109114185,0.11217676,-0.06658343,0.05001845,0.041942842,0.03314916,0.12675324,-0.04362137,-0.0663667,-0.007241657,-0.062267985,-0.028269686,-0.07686085,-0.055330228,0.0044247536,-0.006306339,0.0010379225,0.031142732,-0.07958238,-0.02893678,0.09946022,0.006589792,0.016546644,0.048580676,-0.007452998,0.042142004,-0.02332565,0.054878145,-0.010786295,-0.028358676,0.060550045,-3.501749e-08,0.072389714,0.054925606,-0.035307124,-0.047699694,0.0027083366,-0.03763555,0.0040801866,-0.025878318,-0.0027689682,0.050843194,-0.047137167,0.11726275,-0.025923584,0.0061543053,0.02453934,0.00800635,0.002689063,-0.018837322,-0.0072132065,0.022071388,-0.052081775,0.042675156,-0.061766308,0.022556351,-0.059699073,-0.12892401,0.05878784,-0.0017193599,0.021492919,-0.047983497,0.024277817,0.07083774,-0.011108157,-0.09615762,-0.064867005,0.07569902,-0.026492909,-0.047604974,0.020245235,-0.028254071,-0.0013621012,-0.071379654,0.018826207,-0.0019547427,-0.04551677,-0.02102968,0.04699453,-0.018662538,0.030630808,-0.053828664,0.027485661,-0.006775718,-0.057400223,-0.04716285,-0.13112234,0.06734531,-0.0041747754,-0.0019813231,0.019832958,-0.07118859,0.011711398,-0.057820883,0.10066228,0.022170993 +3.2.1.118,"Highly specific; does not act on amygdalin, linamarin or gentiobiose. (cf. EC 3.2.1.21 beta-glucosidase).",384,0.99999994,0.019014075,-0.08700943,-0.116417736,0.06368422,0.0066408613,0.01827663,-0.0042557972,-0.0039696502,0.040097862,-0.054241344,0.016047375,0.01579661,-0.0707347,0.00638849,-0.06748645,0.01335521,-0.02659062,-0.021744419,-0.03425818,0.03032015,0.0043683546,0.0021595724,0.010421372,-0.024115782,0.0027191543,0.0031458966,0.037624948,-0.012451897,0.019303812,-0.022966005,-0.06525363,0.0029456972,0.007299108,0.0969344,0.012421592,0.04280231,-0.12324795,-0.09637197,0.030680766,-0.033330776,0.05141933,-0.06204706,0.0016049286,0.0008281325,0.025005244,-0.071544826,-0.040379588,-0.047266368,-0.002791624,0.010681441,-0.040107183,-0.10283007,0.01592117,0.101068616,0.04706202,-0.009276342,-0.044861197,-0.02758662,0.027376797,0.09928543,-0.015183114,0.028173566,0.0018468539,-0.009515057,-0.021848917,0.02211599,0.0035272376,-0.11643982,-0.060683887,-0.07771731,-0.016573478,-0.08916095,-0.0013010153,0.06302238,0.028802611,0.066973336,-0.011355108,-0.0043058507,0.0006940925,-0.04093373,0.01087877,0.061331607,0.14400089,0.017317832,-0.0062076575,-0.029046634,0.028986543,0.04784044,0.003478519,0.10467585,0.003778874,-0.12782536,-0.018746696,0.014241154,-0.018707171,-0.0034269383,0.0076725543,-0.09715633,-0.002851156,-0.024243843,-0.052056648,0.06283498,0.022960227,0.015241993,-0.05522296,0.12357836,0.0120000215,0.0027128134,0.0011443095,-0.04717709,-0.09692851,0.03456486,0.04347503,0.0017525641,-0.00805502,-0.012346732,0.078150064,-0.040359326,0.040107384,0.03522105,0.06069067,-0.06351455,0.09976058,0.0059431903,-0.06948189,0.06554081,-0.12849517,1.7662352e-34,0.06542437,-0.06802665,0.01094235,-0.008086318,0.015044942,0.03937615,-0.068054706,-0.072665565,0.05031741,0.009297435,-0.08873112,-0.055938736,0.036020357,0.1462713,0.047756217,0.08704834,-0.066963635,-0.02848426,0.07572006,-0.007149998,0.011606126,0.066967644,-0.07666417,-0.08196366,0.015880853,0.076481126,-0.03641285,0.027888533,0.01566532,-0.007017161,-0.02514419,-0.07755269,-0.059459727,0.043507125,0.028629271,0.13402833,-0.036910586,-0.018936485,-0.0055298936,0.014774694,0.067312166,0.043970287,-0.017851518,-0.030772114,0.05400131,-0.035724156,-0.017435566,-0.00080068136,0.0033657434,0.07096402,0.061789885,-0.029906524,0.062790856,0.0030962152,-0.0024511146,0.07625874,0.034728136,-0.025880657,0.035689637,0.011510407,0.049865592,0.012184586,0.012908319,-0.06799354,0.023008393,0.09208197,-0.13273923,-0.067240715,-0.09894973,-0.023138922,0.0009759703,0.004131783,0.072721265,0.0036214683,0.016273115,-0.04753625,0.01693851,0.05012761,0.004083942,-0.035065107,-0.012151754,0.003977931,0.067583345,0.008500044,-0.010990866,0.051737115,0.026472498,-0.03541952,-0.10836908,-0.0001290153,0.055313963,0.06047176,-0.034241643,0.011978649,-0.05935746,-1.9365797e-33,0.01991178,-0.08739511,0.049942955,-0.049352493,-0.0040810714,0.0074051227,-0.029919915,-0.012841119,-0.0021323222,-0.016997172,0.10622291,0.009078964,-0.004836624,-0.003609525,0.006550944,-0.03175048,-0.06111883,0.021272823,-0.0123465,-0.045407906,-0.059903294,0.08873285,0.051197816,-0.0006025919,0.054787666,-0.03834521,0.03638527,0.043524995,-0.04462653,-0.013204361,-0.036228515,0.07622783,-0.020757249,-0.06334189,0.029180296,0.009856331,-0.0653538,-0.07389969,-0.039324135,-0.08617588,0.016158193,0.08489689,-0.0035914208,0.11376204,0.06925903,0.09824391,0.0059234644,-0.040136177,-0.010502029,0.0015691695,-0.0021425835,-0.018465417,0.025605181,0.017007953,0.06679747,0.012478595,0.036423504,-0.030845271,-0.045311168,-0.014021998,-0.014761596,0.06961382,-0.006960102,0.018660383,0.113174096,0.082366794,-0.05173654,0.051468987,0.038635507,0.04188422,0.07481349,-0.046156716,-0.03419217,0.048854798,-0.021380221,-0.028309286,-0.07425345,0.007329822,0.036647268,-0.064392366,-0.01581694,0.015027384,-0.07491327,-0.037870236,-0.017041614,-0.04934592,-0.0048499,0.08900115,-0.037289605,-0.007067709,-0.041837227,0.036073074,-0.06485827,-0.069405064,0.018091103,-3.379731e-08,0.033139307,-0.0077589704,-0.043892093,-0.07212431,0.009741924,-0.012593497,0.006816339,-0.017197886,-0.013941442,0.036611676,-0.023903953,0.14089404,-0.023569638,0.02139804,-0.019941492,-0.04794405,0.010034675,0.020023542,-0.013753918,-0.013917391,-0.04368868,0.05263415,-0.028474892,0.0031869835,0.023677979,-0.14180598,0.041283973,0.07237119,-0.035686795,-0.07562528,0.039657194,0.0852304,0.0081380075,-0.07094609,-0.0046799607,0.03424609,0.008558971,-0.01849476,0.048068184,-0.008031678,0.0100395605,-0.044815514,0.05509968,-0.020132773,-0.06994891,0.017828817,0.047521982,-0.02589553,0.07230682,-0.06981624,0.030340362,0.044603013,-0.050369702,-0.04217603,-0.070654206,0.008687594,-0.008162555,0.006621791,0.07567129,-0.10347113,0.019831238,-0.04630512,0.09488582,0.04004547 +3.2.1.119,"Also hydrolyses, more slowly, (R)-amygdalin and (R)-prunasin, but not gentiobiose, linamarin or cellobiose.",384,0.99999994,0.04205276,-0.11947026,-0.078674234,0.08360497,-0.0128743155,0.035363667,-0.035798624,0.010153544,0.06544692,-0.02853535,-0.017581765,-0.033232663,-0.046756204,0.042928826,-0.07039203,0.004241535,-0.061081853,0.027566178,-0.036356423,0.086748056,-0.013254056,0.019369707,-0.025082372,0.01748412,0.058542144,0.06331893,0.03926694,0.039402697,0.022420354,-0.019939123,-0.04021469,0.013309994,0.038771864,-0.0072066016,0.028749105,0.11044659,-0.08538998,-0.045151226,0.050482046,-0.06969972,0.042489547,-0.0047534257,0.04042971,0.036687892,-0.018765386,-0.07512615,-0.037189905,-0.046568003,-0.0004737201,-0.019784767,-0.07054393,-0.084167205,-0.029092072,0.12704343,0.025715452,-0.031243771,-0.05977491,0.013122868,0.016419064,0.0013447504,-0.06439647,-0.0014014532,0.014285648,-0.0039651473,-0.048095837,0.0026663356,-0.018796317,-0.016357405,-0.011838985,0.011466121,-0.0002353036,-0.020740086,0.012926091,0.046719838,-0.02229354,0.054813195,0.02648318,-0.050344188,-0.020431178,-0.04094455,-0.0051215645,0.06306282,0.062283847,0.0505006,-0.02905739,-0.042103294,0.07233768,0.035783898,-0.060548943,0.054561235,0.04878156,-0.05567816,0.006476852,-0.061391782,-0.012948392,-0.026247835,0.0154472105,-0.09800157,-0.005224391,-0.061971962,-0.07493586,0.025447646,0.034272954,0.0093425745,-0.030151226,0.11278242,0.0014246434,0.021000996,0.011658704,-0.054818537,-0.09856541,0.03264906,-0.012288883,0.0026909416,-0.005594891,-0.04416466,0.01810797,0.00695164,0.08122516,0.030253442,9.802222e-05,-0.071575485,0.13081233,-0.03070886,-0.014515647,0.06262877,-0.093704216,1.34403535e-33,0.053135034,-0.11876508,-0.002550516,-0.034788437,0.01607289,0.02283653,-0.084711775,0.012357738,0.109521516,-0.054694716,-0.09570778,-0.019001031,0.021047449,0.10152743,0.010201481,-0.034366924,-0.0327647,-0.057035856,0.053511646,0.0033368494,-0.035147835,0.11015219,-0.04216725,-0.035192452,0.0073718936,-0.0068121,0.033637878,-0.011804358,0.04108831,-0.02366931,0.019143283,-0.050623104,-0.071227185,0.055681944,0.007441677,0.10509088,-0.009297712,0.009973645,0.022438055,0.03404438,0.029311204,-0.012809931,-0.04026074,-0.026289495,0.07459038,-0.023203393,-0.07848667,0.03586326,-0.02126108,0.08145756,0.090673395,-0.009178538,-0.0046475,-0.025453156,-0.08092915,-0.016515177,0.041531034,0.042603407,0.0160677,0.031684022,-0.01679098,0.06389576,0.0036747737,-0.060532615,-0.0029565413,0.06635627,-0.099676676,-0.10449091,-0.034485865,-0.03069877,-0.06179446,0.011799792,0.11511406,0.011549556,0.031472895,-0.0437978,-0.0006072161,0.006656208,-0.0106271375,-0.019574372,-0.055968028,-0.04342229,0.01580707,0.052391745,-0.020457555,0.036215488,-0.018811483,-0.010332014,-0.0632541,0.06154313,0.027170336,-0.0051819207,-0.041319948,-0.02941959,-0.05267846,-3.1194384e-33,0.042352207,-0.14849143,0.035787575,0.022609035,0.009756509,0.047900055,0.0043949336,0.022122253,-0.0068080393,-0.09178678,0.1153855,-0.0029168772,-0.04327307,-0.009829298,-0.011344002,0.020055652,-0.014453653,0.046527967,0.034365043,-0.039697837,-0.059151866,0.12912054,0.020097595,0.00061165204,0.100508146,-0.004655325,0.025933951,0.058573768,-0.043911528,0.027293993,-0.007094858,0.07646242,-0.034745008,-0.112245165,-0.0092268,0.07050192,-0.053804558,-0.09637152,-0.08442335,-0.04505446,0.0042344434,0.056644913,0.09638056,0.10571118,0.07198215,0.0671537,-0.04273659,-0.037615288,-0.01545368,0.09122859,0.006423074,-0.03555031,-0.04257406,0.02325992,0.056223616,-0.026170697,-0.023633532,-0.049154673,0.015357688,-0.034240313,-0.013236183,-0.019526277,0.0058513945,-0.03137779,0.037820075,0.04780021,-0.037898492,0.01628683,0.07479938,-0.004716495,0.09992703,-0.022888169,0.01996585,0.07456809,-0.006306898,0.008729873,-0.085498825,-0.04148206,0.042427864,-0.07934104,-0.037241552,0.08405408,-0.07911681,-0.038285382,-0.03571596,-0.0042758295,0.0045787077,0.035439692,-0.033062644,0.020749964,0.007356714,0.014180333,-0.021357164,-0.028558264,0.08221579,-3.3107497e-08,0.07588213,-0.1152814,0.0074392734,-0.014215272,0.059469245,-0.020052716,0.045700904,0.04057766,-0.016688619,-0.026926147,0.021533104,0.08325806,-0.05412161,0.0008344145,-0.035166167,-0.019299729,-0.0010832339,0.020265296,-0.027357776,-0.013552775,-0.09921202,0.05542286,-0.097636566,0.03561389,-0.0025541852,-0.07348442,0.052890696,0.007226441,-0.017732792,-0.10841668,0.09172588,0.067174725,0.025061835,-0.06861375,-0.024790095,0.031132357,0.038368825,-0.016631918,-0.028576063,-0.015987877,-0.0041168937,-0.072833575,0.011803035,-0.023699539,-0.019020012,-0.06873135,0.0389962,0.008083521,0.0739186,-0.12525633,0.08163191,0.04001113,-0.040336017,-0.03708053,-0.018553207,0.04466537,0.01033872,0.00804574,-0.007705368,-0.046470243,-0.013517591,0.026059536,0.14076182,0.04267864 +3.2.1.121,"Does not act on alginic acid, which is a copolymer of polymannuronate.",384,0.99999994,-0.003247433,-0.13607769,-0.01335435,-0.025666459,-0.048762314,-0.0011805444,-0.007220825,-0.041866887,0.03105075,-0.00041245576,0.058476727,0.024745265,-0.055815432,0.047967613,-0.05247798,0.11204383,-0.00017647567,9.675459e-05,0.026778856,0.025170336,0.08832999,-0.009853972,0.062226582,-0.04286321,0.0003535405,0.025362516,-0.021434203,-0.0336437,0.03256039,-0.055129897,0.017699383,0.07959514,-0.026778907,-0.0013784467,0.07251175,0.041702524,-0.08424462,-0.037051987,0.0956459,0.09175808,0.08956307,-0.0046833497,0.007942484,-0.012027549,-0.024781419,0.022181831,0.00017195428,0.02329719,-0.065501,0.04458561,-0.024171002,-0.054735,0.011637201,-0.03165827,-0.08500396,0.023542468,-0.07128864,0.07109008,-0.012213349,0.014038003,0.0029592984,0.054724157,-0.0072525702,0.050519142,-0.014237847,0.0039092856,0.010867547,-0.07925201,0.01353293,0.027853236,0.01932482,-0.016712844,0.0041752513,0.029681075,0.07267852,-0.044878755,0.044161744,-0.13610223,0.0068668914,0.028203309,-0.06526923,0.019157844,0.03556306,0.07318423,0.0016920196,-0.0027290976,0.004361887,0.052914724,-0.109507024,-0.0020063536,-0.025856612,-0.02564997,0.0031006823,-0.01719456,-0.0019624634,-0.036542974,0.0301489,0.056209885,-0.03487153,-0.0032963955,-0.032860212,0.024475006,-0.047224384,-0.13123646,-0.049370166,0.035824228,-0.011280667,-0.021932201,-0.02363944,0.026548816,-0.024475003,0.0031576832,0.0654623,-0.008250385,-0.064542346,0.012369642,0.037174717,-0.035183854,-0.023285855,-0.05475378,-0.035040803,-0.04423696,0.01574768,0.08103405,-0.089234546,-0.016191686,0.023224888,-8.21783e-34,0.00297842,-0.10307517,0.05088206,-0.0786673,-0.004022477,-0.009732783,0.017192317,-0.012768652,0.0006454973,-0.02138846,-0.028075473,-0.048264958,0.046428278,0.1015386,0.025774289,0.013298658,0.03886039,-0.05570585,0.0725985,-0.03444559,0.018842878,0.07558484,-0.047540795,0.013124754,-0.04766204,0.0037077488,0.014802932,0.0006385094,0.022084601,-0.035128333,-0.023710769,-0.00038212037,-0.076331265,0.06752039,0.00030393145,0.106142774,-0.08311113,-0.03181436,-0.03248217,-0.027616233,-0.03966555,0.056786742,0.052947287,-0.0027272694,0.011324221,-0.039543327,-0.0007674184,0.063452125,8.4381805e-05,-0.027940657,0.030380584,0.09706812,0.05056911,-0.017418554,-0.010346446,-0.006253369,-0.017259985,0.00053189433,-0.044694964,0.032046065,-0.020739298,-0.020059599,-0.032865506,-0.021022983,-0.070538364,0.071171366,-0.010308248,-0.045552343,0.022214817,-0.038345996,-0.00049218617,0.03080841,0.046659086,0.033921354,0.017370356,0.011307584,-0.05855697,-0.06620806,0.046970196,0.047577504,0.015502852,-0.07541401,0.034719337,-0.037455194,-0.06858416,-0.010355524,0.066966526,0.055318456,0.04057802,0.03358087,0.027421394,-0.09848405,0.005395602,0.0645155,0.06681454,-2.4035717e-33,-0.021528933,-0.10642505,0.0038980292,-0.0054206587,-0.05973075,-0.0019390115,0.024750752,0.038726013,0.0035032318,-0.021268025,0.11805709,0.022636864,-0.028668879,-0.002439094,0.04143834,0.045502197,-0.06678938,0.09649105,-0.040189493,-0.03136522,-0.024334924,0.14100742,-0.04989695,0.081236616,-0.030491749,0.012637299,-0.08409399,-0.016909815,0.015184195,0.06666597,-0.036078244,-0.026979811,-0.09022046,-0.037463516,0.014069128,0.027926747,-0.020117823,-0.037588336,-0.07454385,0.011544597,0.02692059,0.005034568,-0.005684825,0.085090466,0.115461655,0.05345419,-0.043763112,-0.04224648,-0.029679466,-0.013342211,-0.043146055,0.041491676,0.02107453,-0.039081905,0.09634844,0.12913696,0.016602239,-0.08396029,-0.0676549,-0.064927354,-0.049888127,-0.016815593,0.029628912,-0.07434272,0.0051625473,0.023457827,-0.025461502,0.07282858,0.07205149,-0.0676106,0.13820589,0.088677175,-0.00096269173,0.024063889,0.0041256766,-0.06451251,-0.03840093,-0.02064249,-0.077867806,-0.05100584,0.08321902,-0.020917345,0.019891247,0.0062722038,0.08210665,-0.016291687,0.062361944,-0.02404048,-0.09072317,0.058990717,0.01644091,-0.006702393,0.0106336055,0.099544086,0.012638074,-2.3405816e-08,-0.023420228,0.07212862,0.052279428,-0.08072459,-0.058470424,0.0029783857,0.07639103,-0.02473908,-0.04668242,-0.029873556,-0.028431732,0.011493547,-0.056200497,0.077431336,0.05276471,-0.027122503,-0.01164955,-0.030309994,-0.012868704,-0.09164113,-0.12518227,-0.008454758,-0.03604167,0.08367104,-0.11947471,0.0015660821,0.077743486,0.050593544,-0.040316075,0.014425415,-0.007842821,0.075603075,-0.055599373,-0.014613793,-0.004461112,0.047141,0.08869912,-0.019449439,-0.05329094,0.05115293,-0.001428404,-0.011946624,-0.042329937,0.032797728,0.10584567,-0.048821658,-0.01606953,-0.08495043,-0.011454959,0.03738248,0.124895275,0.010691501,-0.033294003,0.0023238675,-0.034571942,-0.059628095,-0.09115747,-0.028642284,0.010753342,-0.026550882,0.001974677,-0.0545698,0.1410824,-0.06768 +3.2.1.122,"Hydrolyses a variety of 6-phospho-alpha-D-glucosides, including alpha-maltose 6'-phosphate, alpha,alpha-trehalose 6-phosphate, sucrose 6-phosphate and p-nitrophenyl-alpha-D-glucopyranoside 6-phosphate (as a chromogenic substrate). The enzyme is activated by FeII, MnII, CoII and NiII. It is rapidly inactivated in air.",384,1.0,-0.002650889,-0.087705605,-0.081903845,-0.0020151627,0.02879596,0.0071149045,0.029715668,0.015394071,-0.00633223,-0.00082715316,0.0056323707,0.13911755,-0.123578735,0.020602195,-0.104540035,-0.0072442684,-0.03675627,-0.04798575,-0.0710113,-0.004680581,0.10405976,-0.0003741784,-0.051345382,0.0048350655,0.05912517,-0.02225404,0.03393217,-0.03295892,0.022725688,-0.050551996,-0.040590413,-0.008163221,0.10707395,-0.04114661,0.02353328,0.14104958,0.024689168,-0.015280861,0.010683921,0.0065875705,0.02347568,-0.08359805,0.024711829,-0.06302585,-0.061070587,-0.04544918,-0.079975665,0.055926014,0.06460809,0.0829405,-0.02730764,-0.11695796,-0.07214085,0.042814538,-0.020363329,-0.0142617915,-0.06906036,0.0036047825,-0.0010303846,0.018338285,0.004601283,0.07617668,0.030549461,0.09846746,-0.043736964,-0.032619283,0.015308652,-0.029584818,0.010897256,-0.02211911,0.04288995,-0.044165164,0.045260068,-0.0416217,-0.010198442,0.060896803,-0.004650696,-0.06738586,0.063064925,-0.015250457,0.075695954,-0.021482907,0.085983016,0.12667191,-0.006838341,-0.0020008015,0.010102455,0.0023141967,0.05983797,0.0075022182,0.012201098,-0.03956314,0.015272681,-0.052332584,-0.031432807,0.030146005,-0.045405515,-0.02613884,-0.0072106593,-0.015469755,-0.02122305,0.0044746753,0.0030158337,-0.036209516,-0.046086572,0.088379644,-0.038216934,0.060362607,0.046070393,0.006449313,-0.080599934,0.072613485,0.016314683,-0.021521285,-0.03272078,0.04829912,0.039597783,-0.0530869,-0.03753093,-0.04160105,0.0574076,0.038431466,0.060139116,0.06823983,-0.052886363,0.037013065,-0.012904493,-1.10032415e-33,0.06309114,0.0327759,0.045041155,-0.057449967,-0.033971343,-0.051056556,-0.04826621,-0.055094708,-0.06595538,0.036874656,-0.05142176,0.014348286,0.00192081,0.03145948,0.048307568,0.020537276,0.07188714,0.03784253,0.0959015,0.018393753,0.052789696,0.06675315,-0.053856667,-0.0141130425,-0.010794228,0.068742804,-0.040139508,0.070166565,0.035862025,-0.0069030244,0.08720687,-0.09027208,-0.029756378,0.008983561,-0.0043366766,-0.024353454,-0.12947564,-0.011204593,0.015458792,0.021636484,0.0143047245,-0.012962061,-0.017137071,-0.0312788,0.057549175,-0.06452232,-0.090949394,0.04574556,0.052544743,0.042727325,-0.014229315,-0.020253502,0.030770555,0.048132423,-0.019843487,0.0034068422,-0.004241562,-0.021854183,0.0150877535,0.039234713,0.0027534298,0.030699905,-0.021155106,0.010524511,-0.010635759,-0.024031501,0.0075177737,-0.0073861713,-0.05750674,0.06720668,-0.09161058,-0.019000715,-0.0063537476,0.014440555,-0.045980707,-0.10548477,0.07554887,-0.047670554,-0.07511697,0.058087282,0.064339735,-0.043038487,-0.02862597,0.010883113,-0.08422251,0.027520247,-0.077837385,-0.04574858,-0.037712876,0.020254156,0.016551983,-0.057954866,-0.08269798,0.03442069,-0.018355198,-1.8657296e-33,0.11871053,-0.083882935,0.0668217,-0.06580567,-0.0793563,0.04028497,0.093406565,0.014352187,-0.011370036,-0.0026823475,-0.023863414,0.024255605,-0.03288953,-0.08116976,-0.032689992,0.04086342,0.030315064,0.0767386,0.04248612,-0.011257758,-0.014829929,0.099370226,0.010505194,0.04094179,0.073222764,-0.03644248,0.036622383,0.054637566,-0.0021916477,0.04158603,0.033031873,-0.014779579,0.01967373,-0.06984655,-0.039216902,0.01616791,-0.08230419,-0.016197186,0.038588844,-0.025183262,0.027492944,0.06048981,0.08503839,0.044824798,0.067094184,0.10412309,-0.07917175,0.026782885,-0.023036161,0.018539116,-0.02372825,-0.01668363,-0.029119179,0.07143056,0.054563276,0.0020434924,-0.0032683099,0.004681388,-0.06487913,-0.0040987707,0.016672505,-0.06043383,-0.01551863,-0.056713767,0.008348295,0.09418344,0.016206313,0.044762257,-0.024574293,0.03177463,0.01507487,-0.016585631,-0.0022566037,0.0075666704,-0.01564951,-0.03389976,-0.0879137,-0.008369051,0.000693703,-0.022192582,0.0070892414,0.101165704,-0.013205266,-0.05753516,0.070233874,-0.07021593,0.035058524,0.123258255,0.050647136,0.057673544,-0.014005991,-0.029199302,-0.03228634,-0.024310514,0.07397058,-4.789635e-08,0.056687064,-0.082912736,0.015795482,-0.10460294,-0.027057627,0.011884464,-0.0032777737,-0.013988384,-0.026470546,-0.056024365,-0.02435124,0.105259895,-0.01345603,-0.044114415,0.011469556,5.3279276e-05,-0.07960254,0.03225054,-0.009998707,-0.014925534,-0.06387367,0.009721908,-0.119285665,0.06460192,-0.013393518,-0.014866651,0.08406294,0.004930303,-0.009146457,0.04179387,0.012034701,0.041256167,-0.006313969,-0.078359,-0.018096825,0.06752641,-0.06657593,-0.021296665,-0.08013036,-0.03804496,-0.00016727211,-0.009900501,0.0028986975,-0.031198487,-0.03664312,0.013963673,-0.023566565,0.04413432,-0.009491715,0.060770005,0.0023320478,-0.06659581,-0.06067643,-0.056528967,-0.06091891,-0.017281711,0.051079273,-0.12812068,-0.017133582,-0.07748547,0.037553016,-0.035975676,0.17994197,-0.047612097 +3.2.1.123,"An enzyme from Rhodococcus sp. that degrades various acidic and neutral glycosphingolipids to oligosaccharides and ceramides, by cleaving a glucosyl bond. Does not act on monoglycosylceramides. cf. EC 3.2.1.62 glycosylceramidase.",384,1.0,-0.045442086,-0.08747872,-0.10019668,0.006992232,-0.027229322,-0.022537718,-0.0757244,0.025287805,-0.020218108,-0.014026311,0.030470166,-0.025787247,-0.024273373,0.052300133,-0.06615978,-0.030345231,0.009358649,0.026933154,-0.016484141,0.028006135,0.07723143,0.0107499175,-0.019442927,0.040931188,0.03230164,-0.0054325615,0.03720368,-0.10046481,-0.077163436,-0.0326144,0.045601584,-0.06701742,0.09284286,-0.037216987,0.043104183,0.06808917,-0.029441785,-0.012851236,0.10148067,0.021186167,-0.050344158,-0.018891385,0.007326012,-0.051145766,-0.06290973,-0.066490844,-0.03509305,0.067304775,-0.0063810917,0.003441526,-0.024641393,-0.07005795,-0.14633624,0.027712215,0.057502087,0.021307351,-0.11728679,-0.03780923,-0.02713703,0.031217562,0.0643102,0.021572743,-0.006983233,0.09565242,-0.07181016,-0.103466295,0.06465578,-0.03275831,0.00941187,0.046890996,-0.064836614,-0.03249569,0.023602402,-0.03649015,0.053949278,0.060082123,-0.017310953,-0.03022824,0.042142246,-0.07601599,0.035579402,0.0036067087,0.011199726,0.062408328,0.031530373,-0.0097976765,0.07271433,-0.047053132,0.031900175,-0.045026235,0.09512011,-0.037255876,0.05293429,-0.052056525,-0.08988273,-0.019991469,-0.011462525,-0.016469248,0.015359419,0.014423281,-0.027265668,0.019672882,0.04654377,-0.06430716,-0.08804826,0.08838488,-0.06857111,0.06426885,0.064203635,0.013183818,-0.015145508,0.048618075,-0.0036383015,-0.02383408,-0.063666575,0.049286507,0.05760631,-0.053299263,-0.07285535,0.0026671977,-0.0085102925,-0.06312301,0.050044604,-0.033921976,-0.044677734,0.08146693,-0.017893,4.574185e-33,0.040825814,-0.020049065,0.010314228,-0.068960145,0.017191911,0.0052183825,-0.047407314,0.030052168,-0.052961256,-0.0058036903,0.035513572,0.017486826,0.020717783,0.11382878,0.018423364,0.07202681,-0.02187087,0.00693986,0.08286664,0.011613777,-0.0029965376,0.044899732,-0.0042339494,-0.045054365,0.035317697,0.077239394,-0.042231683,0.019538892,0.003426017,0.0215178,0.045319214,-0.054986477,-0.100294806,0.064408295,0.019517642,0.054860495,-0.047103155,-0.12117758,0.037212234,-0.01257221,-0.06876054,0.012382489,-0.033945687,-0.05556345,0.06628071,-0.020350637,-0.0025602994,0.087628745,0.0013160213,0.09770101,0.037992254,-0.027634414,0.07839891,0.024117427,-0.047125325,0.018615613,0.0035884243,0.012218689,0.039230205,0.039526492,-0.0020997974,0.094800636,-0.05685246,-0.032988265,0.016098911,-0.01407708,-0.08533081,-0.037252743,-0.05909249,-0.0028302115,-0.007995191,-0.029576361,-0.008170947,0.017473083,-0.024927376,-0.08053831,0.015856527,-0.009692121,0.027623314,-0.044213794,-0.012584494,-0.0027512873,0.03578388,-0.05528553,-0.048541512,0.037108477,-0.029084302,-0.08430697,-0.02148409,0.052041758,-0.04677237,-0.047387622,-0.09358997,0.07389171,0.0013031405,-6.71277e-33,0.114335254,-0.11082602,0.006597865,0.005965667,-0.029264962,-0.0020934728,0.016193533,0.057580985,-0.029171461,-0.10853505,0.045688156,0.026343295,0.053382657,0.004817207,0.076217555,0.012938324,0.010258143,0.007483649,-0.051977213,0.0015512919,0.035321638,0.074325204,-0.01564425,-0.006270626,0.0636652,-0.0038990306,-0.009042575,0.055451255,-0.014627467,0.013332836,-0.023587901,0.01353766,-0.051569622,-0.07342672,-0.03063416,0.060690463,-0.007760838,0.00559746,-0.009439327,0.0062797447,0.03620743,0.079959005,0.007431959,0.03644504,0.08606556,0.037366558,-0.11112259,0.041508283,0.010702906,-0.07427449,-0.022709206,0.03232403,0.020808728,0.08728711,0.046208084,0.047414158,0.04342263,-0.034731507,-0.020577233,-0.04217698,-0.10113059,-0.04942377,-0.034221075,0.030947357,0.1230424,0.046606634,-0.0070953676,0.014219403,0.033222187,-0.0042993557,0.10357796,-0.030773424,-0.04996697,-0.058923498,-0.03333503,-0.024785439,-0.10026649,-0.043965407,-0.034751527,0.04534115,0.12145299,-0.05542987,0.09813452,-0.009438087,0.008555501,-0.0868358,0.0034508663,0.051209975,-0.0080046,0.048697732,-0.01808949,-0.011170224,-0.012676887,0.020119874,0.11556526,-3.90217e-08,0.061535187,-0.029831277,0.039989125,-0.04363402,0.045222003,-0.016973196,-0.00618544,-0.048158053,-0.0033145908,0.018267503,-0.022882469,0.083761714,0.006513155,0.0350818,0.025864277,0.047837406,-0.06741427,0.015066123,-0.021628156,0.03917531,-0.11146671,-0.013365328,-0.04714024,0.04800761,-0.030983744,-0.070614785,0.12237451,-0.018020475,-0.053773113,0.022053747,-0.03712105,0.06220465,0.026111858,0.009599358,-0.030061238,-0.003447847,-0.01522802,0.006937167,-0.05256732,0.024924777,-0.004831973,0.061203305,-0.089147866,-0.002317236,0.026549546,-0.022282809,-0.013717505,0.01810918,-0.036088772,0.013314243,-0.016710129,0.035304,-0.064833336,-0.06253057,-0.10895834,-0.07314115,-0.043536473,0.010903812,-0.0705579,-0.010726729,0.047212135,0.02003635,0.18606104,-0.025476772 +3.2.1.124,The enzyme from a bacteriophage catalyses the depolymerization of capsular polysaccharides containing 3-deoxy-2-octulosonide in the cell wall of Escherichia coli.,384,1.0,-0.039883427,-0.12868483,-0.049547404,-0.021467175,-0.017006867,-0.011298761,-0.027081542,0.03567012,0.051210333,0.059237007,0.0033841496,-0.0153204575,-0.03562838,0.04139247,-0.010047058,-0.047542103,-0.08572188,0.0844002,0.026187416,-0.016730737,0.11092657,-0.020703252,-0.058561757,-0.030199882,0.061868258,0.057666972,0.018976137,-0.036265433,-0.049768545,-0.06404568,0.0025409164,-0.070680946,0.053473487,-0.05192757,0.10565274,0.060305074,0.0038479303,-0.014088211,0.1219186,-0.03383082,-0.0013873813,0.09731869,0.033115417,-0.03935688,-0.015076211,-0.027821515,-0.027926678,0.051737994,0.066146135,-0.10967641,0.004582218,-0.015395746,-0.07440363,-0.0037485708,0.008309085,0.037038516,0.0103097875,-0.05256199,0.040663883,0.04749774,0.0041282047,0.020301301,0.049552213,0.023078278,-0.070105605,-0.094435334,0.058755223,-0.004529471,-0.056620464,0.06911006,-0.07855606,0.047662918,-0.043301918,-0.012257002,0.03416335,-0.020845102,-0.03307155,-0.114388265,-0.0031993592,0.09193023,0.0056210966,-0.086298615,0.02053714,0.12347507,-0.014630763,-0.028033426,-0.0001029972,-0.034995075,0.005933517,0.035705954,-0.015469062,-0.018198594,0.010808654,-0.012556221,-0.0566195,0.0073821195,0.024964796,0.03344293,0.07855929,-0.013481859,-0.07189696,-0.035485897,0.04772256,-0.04923488,0.06334798,0.0040996154,0.041419398,0.06781774,0.03959468,0.04745906,-0.0009251903,-0.01637348,-0.011790633,0.0068783504,-0.06829759,0.07750027,0.0782387,-0.07668569,-0.03414736,-0.10878179,0.008827724,-0.055519234,0.04195054,-0.052008685,-0.090418845,0.017279532,-0.00043686514,1.3197103e-33,-0.0010042108,0.016305493,0.04195782,0.010557031,0.007254115,-0.037454955,0.011339737,0.02899196,-0.03755684,0.05108567,-0.11461675,-0.0770226,0.08449245,0.11205878,-0.0030173897,-0.048120327,-0.014955733,-0.018973028,0.012527687,0.034684744,0.022389807,0.011315082,0.056747485,0.03426825,0.053886563,-0.009699747,-0.022329964,-0.008671544,0.101988,0.010576965,0.014791836,-0.0043478156,-0.09748958,0.03126921,0.101453334,0.05815561,-0.07562,-0.034467116,0.0021441153,0.027781116,0.0038245665,0.008098011,-0.0044137044,-0.07968171,0.0075500743,0.07269536,0.005982974,0.056736827,-0.026249574,0.062338457,0.040689636,0.08424517,-0.026657518,-0.0054908628,-0.028310604,0.024594149,0.011606392,0.024475634,0.03100295,0.046642594,0.004393614,0.0071117594,-0.034424514,-0.00093295245,0.048487328,0.03649761,-0.026958726,0.021668244,0.023860361,0.0062327,-0.05398133,-0.02971478,-0.03558418,0.039401636,0.009779558,0.034263864,-0.07632784,0.046044428,0.097373575,-0.031291716,0.04418683,0.0377513,-0.009733466,-0.052317098,-0.017220348,-0.008726463,-0.05099173,0.03683241,-0.018622072,0.053650115,0.005593873,-0.096609354,-0.045207247,0.113070264,-0.048409473,-3.931229e-33,0.046651933,-0.13122855,0.0029269347,-0.07232208,-0.057245225,0.00800634,0.014551147,-0.012899847,0.069246426,-0.007779765,0.036843743,0.04252257,0.0007605034,0.03687754,-0.025870405,0.017623976,-0.022066828,0.053318128,-0.06359441,-0.033091974,0.024095995,0.04390814,0.016180875,0.00470645,0.03416595,-0.03564713,-0.0070091086,0.0007926509,0.035705134,0.05243181,-0.0065967916,-0.027348597,-0.004842785,-0.023309806,-0.09759053,0.053309277,-0.043224823,-0.022508321,0.08270186,-0.010162105,-0.015531173,0.0065878658,0.03243151,0.041626945,0.051464014,0.031163415,-0.0632448,0.040164333,0.008672937,0.03433445,-0.070085876,-0.010732429,0.031193225,8.742884e-05,0.0017092953,0.040474392,0.019562474,0.0009376763,0.03217748,-0.09349799,-0.02304521,-0.015026397,0.07548091,-0.011510673,0.010108713,0.0682698,-0.013591278,-0.060832962,-0.011257368,-0.09991391,0.03836177,0.0025669183,-0.09923141,0.032012273,-0.032994296,-0.05119032,-0.12782902,-0.029172897,-0.02340708,0.010894855,-0.0052303043,-0.006362787,-0.019736117,-0.03162112,0.10599232,-0.116229236,0.057064198,0.05934003,-0.03627646,-0.024279408,-0.013491332,-0.04222923,0.03269292,0.064575925,0.06920821,-3.0248902e-08,0.006414127,-0.03264449,0.01904541,-0.061924256,-0.06725767,0.05271506,0.03155785,-0.007615515,0.019000094,-0.08850254,0.04387702,0.12440222,-0.08463854,0.036782615,-0.0013191381,0.099182144,-0.06884674,-0.07036844,0.023305658,-0.044465113,-0.044894587,-0.0031863607,-0.0854031,0.026446909,-0.026152147,-0.023908185,-0.0019195674,-0.01096658,-0.04002678,-0.031303193,0.022772325,0.08997141,-0.046378024,-0.09964848,-0.0090595195,-0.044820566,-3.989201e-07,-0.066337265,0.0025748168,0.031510178,0.067986526,0.031964295,-0.05067583,-0.031287886,-0.0078098793,0.07274617,-0.07702935,0.12794161,-0.054324165,0.04660721,0.082462765,-0.043384835,-0.066777445,0.032167118,-0.10164522,0.0049991063,-0.026465403,-0.05514422,-0.0052383314,0.009244925,-0.034777086,-0.0018641489,0.19262248,-0.015548954 +3.2.1.125,"Highly specific; some other ajmalan glucoside alkaloids are hydrolysed, but more slowly.",384,0.99999994,-0.009592457,-0.06304866,-0.03294602,0.02522438,-0.032058336,-0.039541624,-0.117196694,0.031041719,0.08629904,-0.093957886,0.040124055,0.03938814,-0.019660223,0.031166676,-0.04885444,0.0127037605,0.087208934,0.074462056,-0.12310095,-0.045887873,0.033793323,0.02172222,0.03214918,-0.009342927,0.02763031,0.05950419,-0.0061692493,-0.02555799,0.06715529,-0.03780243,0.011554705,0.038425356,0.021109918,-0.032896884,-0.08386611,0.056464817,-0.10878537,0.02115412,0.09793534,0.05443631,0.013838559,0.001077674,-0.009374698,-0.03032226,-0.039612938,-0.14372618,-0.04478286,-0.043507863,-0.057816803,0.05913133,0.026173197,-0.04343946,-0.060722362,0.01711259,-0.019688474,-0.14718951,-0.1303457,0.038330577,-0.020451434,0.09531082,0.027311586,0.08122742,-0.054480024,0.020558614,-0.034577258,-0.026098374,-0.0037563709,-0.063057154,0.05516171,-0.07770065,-0.001549056,-0.031143146,0.09551061,0.0247084,-0.063432984,0.005676604,0.041084815,-0.032357257,-0.017310912,-0.057344973,0.052743677,0.034469057,0.009311827,0.043010272,0.0006929569,0.033109214,0.01892959,0.111732334,-0.023229264,0.040321365,0.08664396,0.027800381,-0.025289143,-0.03180537,0.03230538,0.039227076,0.0466436,0.0064276857,-0.053867478,-0.01317799,-0.016624128,0.0029257005,-0.012969847,-0.011911965,-0.0076063992,-0.015925504,-0.0044325776,0.03315674,-0.017581105,-0.024258183,-0.01616984,-0.015023889,0.008367436,-0.028851632,-0.06512087,0.061008755,0.0148775,-0.016434621,0.0029567354,0.023803182,-0.008089051,-0.044184748,0.0415098,-0.026368912,0.044610556,0.06463348,0.027790034,2.7833682e-33,0.020885043,-0.01925434,0.014504375,-0.022713976,-0.03164929,-0.044140324,-0.104408205,-0.047352828,0.017732982,-0.0026172274,-0.10768913,0.06927107,-0.051733717,0.050148148,0.027135568,-0.034484677,-0.053623516,-0.043450274,0.056408525,-0.024890566,0.0064106295,0.028111275,-0.07144895,0.0055623744,-0.07508082,0.016051276,0.04618044,0.038366526,-0.02574165,-0.01445588,-0.012276786,-0.05050268,-0.06786812,0.030820342,-0.020113584,0.07741377,-0.0038976078,-0.03372873,0.038034588,0.0104834605,0.02082177,0.035061263,0.017762946,0.0564762,0.03553159,0.0026409233,-0.10068937,0.06771926,0.01140767,0.030622056,-0.01498563,0.064965114,0.03329033,0.01180594,-0.059477996,0.044664145,0.016323343,0.027095655,0.025279038,0.10380717,-0.07770223,0.0543699,-0.0381897,0.02166878,0.0070688576,0.036218744,-0.07619222,-0.08580951,-0.022431407,-0.026551303,-0.033674866,0.03387972,0.10165449,0.031167204,0.029098446,-0.047396656,0.1212318,0.020209698,0.010969771,0.051988035,-0.011318783,0.02210913,0.012482638,0.081266224,-0.045400422,0.026457896,-0.06773998,-0.036936287,0.037519645,0.060110364,-0.07153271,0.03767946,-0.10090766,-0.016310625,0.026121445,-3.9561222e-33,0.07842559,-0.08624838,0.0019657938,0.05391618,0.030235844,0.053200882,-0.027332572,0.051631786,0.040746078,0.020931339,0.041868277,0.021395825,-0.018180728,0.008233255,-0.041910183,-0.0042640064,0.0051039746,0.07689616,-0.0052451766,0.045575283,-0.074910894,0.115416005,-0.04646629,0.008014602,0.12885782,-0.005210812,0.018164169,0.0013840409,-0.06931735,0.085440055,0.04445738,-0.010660782,-0.08505731,-0.064657465,-0.04448464,0.08874,0.019201111,-0.031881608,-0.09072332,0.046682302,-0.01780201,0.017540678,0.038523924,0.04819624,0.09890791,0.06362184,-0.03186449,0.0097194975,-0.03744753,-0.036364064,0.018407218,0.025037345,-0.017407153,0.036384635,0.09817343,-0.014729107,0.02070788,-0.037807588,0.0005958099,-0.02368591,-0.019379027,-0.05137384,0.018658964,-0.08418615,-0.013316202,0.050162558,0.03982526,0.017004605,0.03360564,-0.0059659756,0.07787977,-0.086204655,0.0015917629,0.05428994,0.027649287,-0.030428495,0.0078789955,-0.05327952,-0.03424818,-0.06851518,0.11883806,0.06633152,-0.020934558,-0.09314958,0.040353015,0.05775519,-0.020864155,0.039300863,0.0024313147,0.04312326,0.011863997,-0.054074828,-0.10742727,0.028327452,0.004283627,-2.347591e-08,0.017076956,-0.019524867,0.035809044,-0.002654015,-0.034698255,0.07492859,0.05478334,0.034520414,0.014035187,-0.060607493,0.0052422346,0.09529263,-0.0452641,0.02053275,-0.048387453,0.015320486,0.0076906327,0.032683212,-0.017578049,0.006462968,-0.09411521,0.040874217,0.027871111,-0.090380944,0.011598767,-0.07170141,0.045841634,0.0120036,0.04318877,-0.054641914,0.020864438,0.038659032,0.03883026,-0.08747447,0.016894134,0.03110663,-0.046735253,0.033775102,-0.004772447,0.0061586737,-0.09081756,-0.06283088,-0.022350641,0.02646422,0.008456481,-0.05094603,-0.05492766,0.015082835,0.033880614,-0.042277586,0.052006956,-0.033934917,-0.010478368,-0.11797524,-0.07861515,-0.039547555,-0.02017216,-0.10917709,-0.020746114,-0.15624712,-0.033470355,-0.03320364,0.12945372,0.008150364 +3.2.1.126,"Also hydrolyses syringin, 4-cinnamyl alcohol beta-glucoside and, more slowly, some other aryl beta-glycosides. A plant cell-wall enzyme involved in the biosynthesis of lignin.",384,0.99999994,0.029199285,-0.08107443,-0.08126232,-0.003089244,0.067181274,0.07321448,-0.03545518,-0.005037484,0.052161984,-0.006546827,0.07605323,-0.017068977,-0.16525356,0.026256219,-0.05572969,0.024229633,-0.09527767,0.030083178,-0.09008436,-0.032392,0.039373104,0.0530027,-0.039777204,0.040870775,0.05565493,-0.07639673,-0.010385953,-0.048723686,0.059178267,-0.08422727,0.007857948,0.010704964,0.020591583,-0.0109855365,0.04928762,0.07053984,-0.011041161,-0.024511626,0.09336965,-0.015800007,0.0479271,-0.08008283,0.0131062055,0.007907833,-0.080537654,0.04883543,0.03337404,-0.0221709,-0.016856479,-0.04157824,0.009663627,-0.06906359,-0.035431553,0.009224352,0.008598858,0.0056007365,0.004582008,0.046657506,0.0335398,0.07180698,0.03876807,0.035149653,-0.032152157,0.035243955,-0.15018608,-0.017592343,0.022540811,0.0048836004,-0.0005815248,-0.015042607,0.045957197,-0.057109796,-0.04721838,-0.009192888,0.0068122596,0.02331364,-0.011749952,-0.03729977,0.016342768,-0.06784827,0.0493714,0.08555676,0.035237376,0.058032442,-0.0033246868,-0.06237173,-0.030013219,0.06425257,-0.0017665797,-0.007066915,0.041820772,-0.033749647,-0.05097425,-0.020825408,-0.014460159,0.10219455,0.090867884,-0.058322843,0.001460954,-0.023408273,-0.024177948,0.073602356,0.083932064,-0.11688286,-0.036618613,0.06412759,-0.013483626,0.008779737,0.06464522,-0.008197702,-0.034867644,0.05203033,-0.024075916,0.007444504,-0.01914249,0.04939609,0.07529066,-0.05898471,-0.03289574,-0.0024632912,0.02654688,0.026710803,0.07385281,0.07779981,-0.049114376,0.063334174,-0.044453114,1.3541116e-33,0.050370455,0.014082445,-0.08665136,-0.0108693885,0.04477067,-0.07766362,-0.038833763,-0.01255469,0.009732248,-0.0026152148,-0.06343459,-0.06990921,-0.06829861,0.06007385,0.02853623,-0.008754912,-0.050470583,-0.0801002,0.04999549,0.002858654,-0.030426633,0.04071771,-0.13167551,0.00628633,0.035774916,0.019984301,0.084649496,0.023150634,0.044623718,-0.04320298,0.10413516,-0.052447695,-0.03424312,0.03650695,0.05053359,0.03252847,-0.010418863,-0.022970835,0.021053342,0.03769383,0.018970722,0.026312718,0.004710996,-0.057180084,0.062442303,-0.004842955,-0.12898345,0.031120075,-0.002784195,0.009268235,0.07957039,0.018115573,0.039614107,0.05730994,-0.010217254,0.014716324,-0.022158487,-0.03075765,-0.017501807,0.0003371376,0.018258344,0.028522577,-0.047692392,0.024957538,-0.008352991,0.029221812,-0.05384367,-0.020192534,0.02302345,-0.07007967,-0.08537865,-0.07244004,0.0072553344,-0.058386568,-0.03919141,-0.0143826995,-0.020192686,0.0178291,-0.031702973,0.00369874,-0.044806436,0.028229078,0.0016301514,-0.017775247,-0.021179715,-0.0002351861,-0.028778631,-0.02433957,-0.03543861,-0.077459745,-0.008642702,0.005814093,-0.026484158,0.047332354,-0.013822054,-3.2487655e-33,0.07922829,-0.10936238,0.09067218,-0.018255409,-0.013586455,0.06337766,0.0030405198,-0.07752272,-0.04003598,-0.021545907,0.00043395985,0.021564366,-0.01684918,0.017123865,0.04008699,0.004898817,-0.009969605,0.060154684,0.018786835,0.013521425,-0.028254932,0.13184291,-0.03275624,0.016697086,0.050362777,-0.015079481,-0.018649783,0.03273165,0.04274486,0.017132241,0.0032114661,-0.032327875,0.014797824,-0.06333588,-0.074896134,-0.026104935,-0.019908715,-0.024211122,-0.058715053,-0.021162817,0.06770615,0.0322973,0.052691612,0.023589686,0.037378486,0.082728416,-0.1067202,-0.049289238,-0.056741215,0.024745155,0.044196192,0.024690012,-0.048894156,0.04095052,0.04462328,0.02356055,0.024069237,0.0019681994,0.018059844,-0.053908084,-0.06639058,-0.034924768,0.04465081,-0.02104237,0.04256743,0.10088881,-0.020625832,0.061325476,0.031605586,-0.034638293,0.098748446,0.053770732,-0.01135618,0.113497235,-0.009473223,0.008470027,-0.07028768,-0.06442929,-0.024491183,-0.033136643,0.02349283,0.001013949,-0.0125556635,-0.0345406,-0.02295517,-0.09629219,0.040603694,0.12178551,0.062260967,0.0010440368,-0.02196356,0.022763845,-0.021324407,0.07292164,0.02830312,-3.2943795e-08,-0.055113662,-0.0031958972,0.04844717,-0.07435545,-0.06401906,-0.05393809,0.09386139,0.07113265,-0.038763463,-0.045302633,-0.055690393,0.071091644,-0.037955947,0.035033338,0.004717979,0.017712886,-0.05771529,0.018367058,0.0053653056,-0.01172628,-0.035748817,0.05934846,-0.086572506,0.088182546,-0.04313741,-0.09707564,-0.024055526,0.0761776,0.07079773,-0.011785219,0.06815282,0.10977165,0.032770224,-0.09468761,-0.061040632,0.07922425,-0.031598717,-0.08794911,0.002738233,0.0037808665,-0.010181779,-0.082336895,0.008207056,-0.043593086,-0.026049057,-0.07718781,0.046489716,0.03314572,0.048439376,0.07473775,0.0517684,0.032586727,-0.022520687,-0.065268554,-0.111715965,-0.020637723,0.0019917104,-0.014420849,0.043607768,-0.0748502,-0.011003166,-0.028837355,0.18037178,0.014781448 +3.2.1.127,"The enzyme from Aspergillus niger does not act on 1,2-, 1,3-, or 1,4-L-fucosyl linkages.",384,1.0,0.03231177,-0.07472869,-0.088297814,0.0049670623,0.055534955,-0.039242893,-0.10233962,-0.024394855,0.009376444,-0.07232882,0.07135949,-0.055527065,-0.03217621,0.06631671,-0.11011275,0.04821032,-0.010714636,-0.010944429,0.0022862358,-0.012697989,0.057836033,0.043699916,0.039392117,-0.0042947805,0.04284286,-0.098525204,0.014907362,-0.024721064,-0.022884928,-0.15753712,-0.05614476,0.0017441645,-0.057465434,0.0035190918,0.10291095,0.019969307,-0.0018160442,-0.0040264158,0.09843692,0.050554786,0.018697705,-0.03694228,0.0033905182,-0.07742225,-0.045094237,-0.01675187,-0.032444447,0.047450263,0.026801402,-0.003625429,-0.06881493,0.004447141,-0.05686388,0.026606893,0.026660541,0.031603772,-0.090684265,-0.0058307946,-0.07507474,0.09045708,0.04667927,-0.004251214,-0.043802623,-0.024753364,-0.008106485,-0.045346323,0.04774,-0.05141391,-0.097874895,0.010388233,-0.04414396,-0.076748796,0.057321068,0.05418982,0.073006734,0.11774352,-0.008320859,0.008786127,0.02440963,-0.03772449,-0.016429735,-0.005040682,0.118441895,0.016589638,-0.0007160171,-0.04537304,-0.021386724,0.021742446,0.004171229,0.031300616,0.093786374,0.021476766,0.01967645,-0.030531257,0.07613966,0.039669007,0.03016616,0.09011507,0.016353237,-0.020154562,-0.027099155,-0.002463163,0.010639461,-0.002396644,0.02744915,0.041594617,-0.002173498,0.024236847,0.06043398,-0.06676431,-0.0016157537,-0.004157029,0.10724028,-0.05140938,-0.018287344,-0.08163968,-0.0012819868,-0.059724126,-0.044868782,0.033422083,0.015007785,0.038366925,0.05593243,0.06988367,-0.098238766,0.05612682,0.003916052,-3.3782378e-33,0.06431588,0.059949752,-0.0043173707,-0.08463791,0.03210299,-0.012014228,-0.039437424,-0.015696228,-0.06117618,0.044852898,-0.078861326,-0.031843506,-0.01635084,0.0310039,-0.013797094,0.046858512,0.09705021,-0.06299621,-0.023056636,-0.04202245,0.020453481,0.03197269,-0.09501984,-0.0013641122,0.012758122,0.07456131,-0.025911942,0.030877229,-0.0031070726,-0.01612214,-0.026486035,-0.06429419,-0.075759396,0.00844975,0.05906685,0.008733055,-0.026517287,-0.043208472,-0.095561214,-0.039658587,0.017456638,0.09615086,-0.031959508,-0.0739317,-0.019299526,-0.034664106,0.024781961,0.06882086,-0.009056425,0.08956402,0.081675425,-0.0038940376,0.079952106,-0.006477829,0.035707925,-0.005404878,-0.03773953,0.043415733,0.01429765,0.029248592,-0.04874448,-0.048901618,-0.045155086,0.014683202,0.00018200872,0.04232915,-0.06567016,-0.009100315,0.007545294,0.012064865,-0.03356748,-0.009122929,-0.020691294,0.0052400962,0.014915006,-0.09543594,-0.05536769,-0.05494114,0.050505508,-0.004069142,-0.013168776,-0.054818995,0.011937857,-0.037764926,-0.09579861,0.0030442076,-0.0068838857,-0.018000705,-0.021608235,0.003983026,0.0129165705,-0.045531914,-0.03540818,0.064233266,0.11447779,2.091178e-34,0.07425971,-0.012525059,0.054136023,-0.034119025,-0.08639067,0.112240806,0.082143575,0.017715944,0.02604647,-0.01305223,0.14653403,-0.020708567,0.009016671,-0.03742538,0.022863174,0.058094285,-0.023393273,0.09913408,-0.006862513,0.022236744,-0.061729837,0.07561261,-0.030406207,0.10166054,0.020315796,0.06749037,0.011010163,-0.017832987,0.015030743,0.059212696,0.009932806,0.09168157,0.0016752133,-0.040755,-0.01785677,0.04121493,-0.008620438,0.034206204,0.029735632,-0.0009636628,0.07993956,0.09124303,0.006724343,0.0842781,0.03137167,0.049237717,-0.021728318,0.015370185,-0.0040387507,-0.10195543,-0.042924885,0.044548206,-0.0013290079,-0.050982222,0.017780598,0.0189849,0.05759253,-0.049687527,-0.035104476,-0.036829606,-0.091765866,-0.03940381,-0.015570073,-0.031483788,0.06517426,0.033726398,-0.0485329,-0.016934918,0.12673183,-0.015292848,0.05171911,-0.0004328434,0.027883312,-0.060045432,-0.05685668,-0.011301217,-0.05803559,-0.028979221,0.00012471412,-0.01419761,0.05131532,-0.0055255955,0.04010175,-0.05541334,-0.020443242,-0.07394831,0.055580743,0.065296076,-0.041374896,0.08871851,-0.014594351,-0.00079950073,0.0049612327,0.020616084,0.019096417,-3.090912e-08,0.104760736,0.043371025,0.08096092,-0.058232922,-0.027584963,0.07824835,-0.01751941,-0.019216472,0.034390815,0.06306655,-0.0890175,0.09096981,-0.057019625,0.048880182,0.04110704,-0.042147227,-0.057411406,0.0019392036,-0.003644947,0.028801164,-0.09622696,0.006118402,-0.08495012,0.04534461,0.012917447,-0.063359156,-0.006882512,0.033919204,0.050078455,0.048463866,0.019766357,0.06089837,-0.050100777,-0.04246277,-0.12055886,-0.021422688,-0.021090554,-0.027314274,-0.084085874,0.028778926,0.026301153,-0.066858865,-0.05767343,-0.037000198,-0.060324386,-0.03670367,0.0015654104,-0.02932703,-0.047984023,0.008516168,0.05035574,0.007545562,-0.055745963,-0.017693438,-0.023636185,-0.04545072,0.047765918,0.033278935,-0.04231387,-0.07984706,-0.019638397,-0.06256501,0.08934537,-0.07144412 +3.2.1.128,The enzyme from Aspergillus niger is specific for the hydrolysis of the triterpenoid glycoside glycyrrhizin from roots of Glycyrrhiza sp.,384,0.99999994,-0.023133796,0.006590447,-0.13596265,0.012085942,-0.0021663413,-0.0021579205,-0.11080115,0.042715974,-0.046745885,-0.074617766,0.04648553,0.010764402,-0.018935364,0.026710205,-0.12823384,-0.057158135,0.050297968,0.019545238,-0.039913896,-0.06881745,0.08137462,0.07084319,-0.022122396,-0.031562835,0.040561672,-0.04594249,-0.016960194,-0.0038603393,0.053564843,-0.07650115,0.018312408,0.002632055,0.01534244,-0.023001507,0.07944727,0.09535803,-0.062515594,0.023615293,0.10248754,0.013622399,0.05929883,0.018846987,0.07723886,-0.102549665,0.04489723,-0.023688596,-0.023420038,0.030741898,0.030669538,0.02242147,0.0117785325,-0.04270142,-0.0492424,0.03942365,0.044312667,-0.0034680748,-0.02010779,-0.056603707,-0.040809244,0.108207725,0.014447929,0.029574974,-0.014315191,0.0031693825,-0.09647806,-0.069772884,0.07588064,-0.04856105,-0.04976109,-0.03152306,-0.05605158,-0.06947363,-0.035435576,-0.041086003,-0.048617553,0.021602897,-0.06864006,0.022609621,-0.001262569,-0.0529188,0.10318167,-0.056799658,0.122630954,0.08480997,-0.052559283,-0.0091779,-0.020672536,0.021651639,0.071173884,0.02604953,0.08886005,-0.003921495,0.07318962,0.030212566,-0.060278572,0.043093722,0.03438153,-0.0059608286,-0.036578417,-0.04117023,0.0047909003,-0.03831987,0.005353737,-0.06978538,-0.008828821,0.088866144,0.012329522,0.024132371,0.118423805,-0.03562637,-0.06099741,0.07405552,-0.00809053,-0.0688419,-0.002209147,-0.051119573,0.04146525,-0.034643736,-0.0014787443,0.032408826,0.04644742,0.031328443,0.04735689,-0.010949555,0.012485895,0.04902839,0.043794625,3.7683682e-33,0.05268675,0.07550428,0.009644324,-0.109961495,-0.011763686,-0.013619566,-0.005773493,0.036700517,-0.027381917,-0.039807316,-0.057180606,-0.0016712557,-0.080468744,0.02388334,-0.05730402,0.08883474,0.007977481,-0.045893542,0.012882568,0.04139079,0.07419201,-0.026647765,-0.11807445,-0.019529723,0.09357952,0.032202773,-0.0073575587,0.008644149,0.028950887,-0.025175655,0.0025025138,-0.058946066,-0.11006785,0.04318903,0.10651527,-0.020832747,-0.016167602,-0.018836288,-0.014428551,0.043464858,-0.017715357,-0.017617708,-0.030021124,-0.057778545,0.022210192,0.06363543,-0.045720294,0.059217896,0.06823862,0.07119621,0.05155182,-0.029918535,0.057291582,0.074054115,-0.08307747,0.028487515,0.019065753,0.017000375,0.040261637,0.046104565,-0.04942713,0.025731757,-0.0111866845,-0.016817775,-0.021884967,0.004264621,-0.06809968,-0.012430652,-0.02073721,0.009659582,-0.0681924,-0.03634152,0.062773734,0.040470798,-0.016333092,-0.058802802,-0.018369367,-0.01764042,0.018953005,-0.008071092,-0.05356273,-0.004276416,0.03293733,-0.06456598,-0.11332839,0.060456514,-0.0071630734,-0.037757542,-0.0024318832,-0.01588148,0.017035462,0.015943883,-0.04369554,0.020534934,-0.0054729907,-5.159293e-33,0.12261575,-0.05089966,0.0019769734,0.0004675924,0.008362996,0.024106432,0.008459999,-0.03285208,0.012549832,-0.03870397,0.003013173,-0.0053935023,-0.004245807,0.021763738,0.008433829,0.0056106313,0.011271828,0.14523174,-0.017929064,-0.072735496,-0.029555183,0.044575125,-0.010682196,-0.019870127,0.051301394,0.008172801,0.04047194,-0.00058516365,-0.0212539,0.13357739,-0.014048805,0.021043273,-0.053030513,-0.005359408,-0.04379733,0.11700065,-0.09123317,0.02814576,-0.016492741,-0.034621477,0.009523474,0.028839499,-0.018238558,0.09240919,0.07721341,0.06920095,-0.058188174,0.028905015,0.030987578,-0.064675964,0.04467889,0.030558739,0.042483535,0.06677253,-0.0012671872,0.03196373,0.038660947,-0.0558216,-0.006565047,-0.03824127,-0.038538802,-0.024903685,-0.054319993,-0.023035105,0.020652471,0.07135841,-0.0024436275,-0.020458102,0.08081664,0.019717863,-0.04395651,-0.015171411,0.03267821,0.05514696,-0.060075354,0.08495852,-0.033915114,-0.0860279,-0.049219895,-0.03490571,0.058879115,0.031222183,0.023241742,-0.04921797,-0.06367493,-0.14422734,0.017585546,0.1085467,0.01664888,0.035131764,-0.03964957,0.042754818,-0.100523874,0.024727177,0.02643282,-2.8871979e-08,0.07055247,-0.02468541,0.03342443,-0.04477065,0.03191472,0.06473943,0.015245959,-0.015319764,0.07476348,-0.022341693,-0.06485286,0.04387433,-0.018428765,0.019820346,0.0108201895,0.06919243,-0.030937215,-0.0037642503,0.008577633,0.065235525,-0.06503428,-0.063071206,-0.097534224,0.035136055,-0.01632399,-0.05535906,-0.0014451485,0.03678543,0.011377244,0.048762355,0.00861245,0.05418731,-0.035184167,0.006030756,0.014143536,0.022104675,-0.04286296,-0.03287792,0.0058737267,-0.057544705,-0.05379254,-0.070583135,-0.040585354,-0.021189153,-0.065471716,-0.04820732,-0.005245268,-0.041326944,0.018651027,0.051086858,0.009935795,-0.040608983,-0.037746076,-0.035549894,-0.035577055,-0.01580123,0.025308708,-0.016276002,-0.08422101,-0.098597236,-0.08941581,0.0157281,0.1828993,0.016480654 +3.2.1.129,"Although the name endo-N-acetylneuraminidase has also been used for this enzyme, this is misleading since its activity is not restricted to acetylated substrates. An exo-alpha-sialidase activity is listed as EC 3.2.1.18 exo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase.",384,1.0,0.011494026,-0.08642668,-0.10981555,-0.034899123,0.043608744,-0.0033258207,-0.0049439287,0.06138368,0.02488336,0.020187119,0.07949394,-0.02801984,-0.13342746,0.07952796,-0.055434167,0.06866466,-0.049153242,-0.034084667,0.03743068,-0.060122862,0.05027364,0.03144259,-0.039211366,-0.026394432,-0.025071936,-0.013320264,0.0017848506,-0.04095472,-0.033054795,-0.0818139,-0.0031936488,-0.050211076,0.0898813,-0.06179396,0.055924617,0.058495697,-0.11600867,-0.058959644,-0.014717433,0.010004284,0.07254544,-0.046524968,-0.026069522,-0.032101415,-0.046554897,-0.04340032,-0.032514863,-0.010518931,0.08029155,0.009661469,-0.032955665,-0.13285488,-0.027262017,0.0186925,-0.006181799,-0.047844384,-0.025114508,-0.017592102,-0.05084381,0.10039657,0.06364039,0.04996237,-0.005426769,-0.04482907,0.008961439,-0.0015273131,0.096154936,-0.10209934,-0.07062648,-0.04261312,-0.051698044,-0.062356446,-0.033275366,0.045637142,-0.031345323,0.055901863,0.0016533434,0.0030598568,0.03235755,-0.054350533,0.023114402,0.0033001602,-0.010966505,-0.006544328,0.020885762,0.07251919,-0.050244402,0.03269694,0.109684,0.061420728,-0.0032644167,-0.06792441,-0.0073520322,-0.064830236,0.040585086,0.017958455,-0.030714864,0.0034847166,-0.009670407,-0.05849619,-0.0026706157,0.045341358,-0.03990964,-0.06510654,-0.030317906,0.052431867,0.047904473,0.01810114,0.06328787,0.028461928,-0.064741746,-0.07713214,0.062476173,-0.08061619,-0.030865813,0.06446544,-0.012781219,0.0011676243,-7.222875e-05,0.0021714119,0.082960315,-0.011833038,0.05600056,0.026964959,0.028585633,0.11243134,-0.06398475,1.2462564e-33,0.026314411,0.03073235,-0.0025654451,0.0025905562,0.06276991,0.016671585,-0.06853953,0.021747615,-0.022806294,-0.083178915,-0.09406039,-0.01540421,0.011367033,0.0075209644,0.057925362,0.05127075,0.04378748,0.016937805,0.02316867,0.02621271,0.06047601,-0.01774653,-0.00586175,-0.018957943,0.017984312,0.07479164,-0.040412184,0.026112901,0.047683287,-0.010097774,0.008531835,-0.045529194,-0.108571716,0.024869137,0.056012765,-0.046608187,0.023172216,-0.013434826,0.0051275413,0.028256346,0.03273692,0.081493035,-0.020508887,0.0123910345,0.036640357,-0.099963844,-0.038256284,0.05176656,0.11552928,-0.04734744,0.015747191,-0.04688331,0.021152798,-0.042298324,-0.019979293,0.043690562,-0.02379177,0.084566385,0.04892167,-0.004562449,-0.009931766,0.050395925,0.0103928605,-0.0147081055,-0.061255485,-0.001238332,-0.016570935,-0.009879881,-0.0041298233,-0.0123418,-0.0450808,-0.021359218,0.03788088,0.034217637,0.04448301,-0.090862,-0.041934345,-0.024711331,0.05157212,-0.04371335,0.052279435,-0.013533351,0.02641703,0.040772412,-0.064967245,0.06327147,-0.042290412,0.018785993,-0.04602031,0.03267797,0.025166867,-0.047759928,-0.070036836,0.09563072,-0.0026784916,-2.646642e-33,0.08567551,-0.049501963,0.032923777,-0.13160399,-0.017670257,0.08602954,0.027537748,0.038474903,0.012584172,0.013363887,0.06850179,-0.030506752,0.03810128,-0.08688588,0.048373334,-0.0006141951,-0.0040421663,0.06122014,0.031232031,-0.09589094,-0.007624914,0.015135511,0.0002491274,-0.0081107225,0.083459914,-0.03289179,-0.02205682,0.0727924,-0.06329485,0.021325603,-0.039985433,-0.044599053,0.0037983998,-0.058932845,-0.031344812,0.049669005,0.04073469,-0.024631599,0.002315731,0.0040037516,0.045647662,0.045253266,0.08383947,0.09582249,-0.007320588,0.07452172,-0.112254575,-0.008454489,-0.027768519,-0.050230138,0.045005552,-0.03673891,-0.058079023,-0.009742223,0.036772747,0.05175672,0.015071916,0.06388321,-0.12832196,-0.042379428,-0.022198228,-0.032664083,0.030278841,-0.019082407,0.085050374,0.082921,-0.027544139,0.06701205,0.03645342,-0.053974193,0.04081416,-0.033205885,-0.054633792,0.06966203,-0.025258146,-0.027836645,-0.03337845,-0.09634519,0.061885975,-0.06712153,-0.022302845,-0.012573079,9.684985e-05,0.012127554,-0.002221427,-0.057816762,0.06609051,0.10062076,-0.050816834,0.05961079,0.00021367417,0.013354264,-0.076018915,0.059107807,0.021679776,-3.9839026e-08,0.08067129,-0.06460176,0.015412031,-0.102442935,0.0013767258,-0.05001564,0.0034567735,0.051173892,0.092438966,-0.049850743,-0.021514349,0.0478106,0.023020782,0.08177572,0.041110307,-0.029469302,0.07136282,0.099335186,-0.015617143,0.03555766,-0.064342536,0.014267223,-0.06671374,-0.08538526,-0.01784281,-0.0687678,0.019010121,0.052911375,-0.030279426,-0.03284516,-0.06824228,0.004486833,0.016656538,-0.010196266,-0.027147701,0.078332886,-0.02055459,-0.061025493,-0.045098525,0.025239754,0.039794642,-0.049289096,0.0025250218,0.010683206,0.021148058,0.04074215,0.011718549,-0.0030839446,0.016277142,-0.036656022,0.07095656,-0.046429276,0.02022405,-0.0817999,-0.105191685,-0.05160922,-0.023591135,-0.028807422,0.01779138,-0.06918118,0.073022105,0.012322446,0.14646238,0.044575434 +3.2.1.130,The enzyme catalyses the hydrolysis of the terminal alpha-D-glucosyl-(1->3)-D-mannosyl unit from the GlcMan9(GlcNAc)2 oligosaccharide component of N-glucosylated proteins during their processing in the Golgi apparatus. The name for the isomer is based on a nomenclature proposed by Prien et al [7].,384,0.99999994,-0.027030751,-0.071551934,-0.0759045,-0.034588527,-0.01200026,0.0013040785,-0.005407656,-0.0044596912,0.069566734,0.007868801,0.08093498,0.018318372,-0.0992834,0.042229794,-0.02525487,-0.073460415,-0.0314128,0.05045249,-0.043006882,-0.13224861,0.09417011,0.024273204,0.013054712,0.014915127,0.061259642,-0.053781204,0.013277143,-0.051155012,0.04155517,-0.051943462,-0.0049583726,-0.11784852,0.06535706,-0.02609196,0.057251893,0.021125125,-0.0052720467,-0.02149604,0.03496541,-0.0136065595,-0.0037073256,-0.073273025,-0.0099259345,-0.022784587,-0.115055524,0.02607807,-0.05100406,0.049743257,-0.024988905,0.042255506,0.001714418,-0.07194947,-0.0983149,-0.02201373,0.037821453,0.04119289,-0.025524858,-0.054218613,-0.0035976758,0.07442858,0.018456282,0.057790514,-0.018598562,0.003094218,0.0011048117,-0.07909988,0.0729434,-0.080670044,0.012564565,0.0020422798,-0.010914943,-0.0868413,-0.030722177,-0.074413106,-0.027655667,-0.006114753,-0.054728683,-0.016526615,0.047011513,0.028688734,0.09229634,0.04778591,0.096486285,0.0977386,-0.06698367,-0.018731993,-0.06396819,0.06006484,0.08797548,-0.017192788,0.016532464,-0.047471307,0.03711471,0.035036914,-0.014192628,0.013061037,-0.00028542342,0.03545735,0.030986112,-0.0057980116,-0.012725664,0.011201077,0.03501034,-0.12159818,-0.021231296,0.05923096,-0.005954574,0.078287385,0.04476625,0.0022852307,-0.017653177,0.04915053,-0.004671019,0.003677551,-0.103410095,0.052700624,0.07069448,-0.07727116,-0.03263571,-0.02688219,0.019689152,0.0108003775,0.04348116,0.08736828,-0.035022154,0.020844953,0.00021842048,6.886703e-34,0.03912349,0.0119652385,0.04086999,-0.014020243,-0.041416455,0.011098424,-0.012640746,-0.0020946506,-0.031068338,0.046210114,-0.09178443,-0.035266377,-0.05341604,0.13597143,-0.044134997,0.050030287,-0.02867348,0.038447898,0.03275171,-0.024045862,0.025795912,0.108294114,-0.013183757,0.012105097,0.09014287,0.0835007,-0.113434605,-0.0086395,0.045072958,-0.021650752,0.06770505,-0.0710076,-0.08156531,0.016649952,0.023101507,0.018631056,-0.06641487,0.000865368,0.008219241,0.046833694,-0.010986146,0.0012512207,-0.05780665,-0.05432035,0.028007757,0.000839968,-0.015547291,0.06550109,-0.019281786,0.0633295,0.04329592,0.012032736,0.018889992,0.070387304,-0.062727205,0.023541491,0.0037910775,-0.014853285,0.036918916,0.05744774,-0.018833714,0.076892994,0.01449281,-0.02590124,0.016034532,0.0109344805,-0.018055655,-0.022897288,-0.006899193,0.04865121,-0.06817549,-0.03849145,0.051899724,0.0006580825,0.017329609,-0.08684783,-0.04246306,-0.010800639,-0.013445436,-0.027203644,-0.0077156527,0.06753589,-0.015971974,-0.0010237201,-0.10338958,0.025592966,-0.032506205,-0.0497811,-0.04029572,0.013173391,-0.018789722,-0.0073654405,-0.10207037,0.12553427,0.023206415,-4.2007584e-33,0.1097003,-0.1433666,0.03590583,-0.049979504,-0.041419048,-0.04463485,0.058857154,-0.025810959,-0.003985573,0.009834652,0.031192582,-0.0069960263,-0.04505359,0.04009862,0.026684213,-0.04872111,-0.046294026,0.09192665,-0.017706633,0.045103725,-0.04151018,0.09087451,0.009251083,-0.006795985,0.098811835,-0.017943,0.08350941,0.022276172,0.009928877,0.086845994,-0.023816537,-0.031683326,0.0029437449,-0.047806393,0.016659947,0.05084679,-0.05883028,0.081965685,-0.026084406,-0.064125665,-0.07868951,0.068484336,0.03822998,-0.0040247585,0.024120096,0.088463485,-0.05639311,0.008687936,-0.107664004,-0.045206778,0.029711498,-0.00308212,-0.019462928,0.03142894,0.06145896,0.10225686,0.018482689,-0.033976324,-0.038257767,-0.007809434,-0.039143052,-0.031627283,0.06394574,-0.015508262,0.0524104,0.053651966,-0.054090947,0.048194952,0.011517118,0.009122382,-0.00092128944,-0.0416974,-0.013674611,0.04074104,-0.027279569,-0.061018743,-0.10548849,-0.038985167,-0.0368425,-0.03662638,-0.0006429632,-0.059289727,0.0072591854,-0.025435127,0.014584526,-0.09467408,0.095443435,0.15791044,0.03486139,0.08365685,-0.018367102,-0.0116274,-0.056764428,0.046070147,0.07576595,-4.1940574e-08,-0.013355664,-0.0066675455,0.03203624,-0.05993662,-0.036634177,0.03981568,0.0012572847,0.012837536,0.0096789,0.04070024,0.04733336,0.062715,-0.04589064,0.024438174,-0.024013607,0.01726393,-0.09174896,0.011023254,-0.01325542,-0.022151448,-0.14139192,0.013170796,-0.050700393,-0.061821327,-0.0041105673,-0.053541243,0.038448382,0.09697408,-0.017558686,-0.02347401,0.043678887,0.05895057,-0.0066512953,-0.03882806,-0.007024238,0.051991906,-0.021848144,-0.038365643,0.025608407,-0.013592,-0.05073743,-0.022517763,0.01417169,-0.029762587,-0.0022065367,0.03502296,0.0042510796,-0.0012655084,0.0077201384,0.09551699,0.018966269,-0.009466186,-0.09486775,-0.03817692,-0.047539506,-0.051437598,-0.077893086,-0.015380534,-0.02376986,-0.05056746,0.021502618,-0.06354927,0.12465714,-0.060520273 +3.2.1.132,"A whole spectrum of chitosanases are now known (for more details, see {http://rbrzezinski.recherche.usherbrooke.ca/::http://rbrzezinski.recherche.usherbrooke.ca/}). They can hydrolyse various types of links in chitosan. The only constant property is the endohydrolysis of GlcN-GlcN links, which is common to all known chitosanases. One known chitosanase is limited to this link recognition [4], while the majority can also recognize GlcN-GlcNAc links or GlcNAc-GlcN links but not both. They also do not recognize GlcNAc-GlcNAc links in partly acetylated chitosan.",384,1.0,-0.03820805,-0.12506744,-0.000512215,-0.002369635,-0.009666622,-0.031200463,0.008508613,-0.02188521,-0.022975253,0.05006265,0.07156673,0.014242503,0.004651881,0.08572902,-0.12805931,0.04476765,-0.004133805,0.005756959,-0.052729134,0.048605222,0.04701852,-0.038632482,0.032139014,-0.0069936304,0.012632153,-0.002469637,-0.01497993,-0.024169229,0.015999243,-0.069530554,0.009290889,0.00038332105,-0.07350196,0.0015530556,0.048339155,0.04588452,0.007362266,0.002671162,0.08630302,-0.024723664,0.063638896,-0.0337691,0.013804682,-0.060880557,0.0037090925,-0.04051539,-0.05794472,-0.011398214,-0.05242324,-0.010616793,0.009622428,0.008230516,0.005556403,0.04717396,-0.028405879,0.048706762,-0.08144575,-0.0515266,0.035074662,0.15534078,-0.0075586163,0.005809109,-0.047803357,-0.0715964,-0.017828284,0.017714744,-0.012618808,-0.0032423013,0.017149497,-0.021592554,0.023120878,-0.035129018,-0.035637148,0.08383581,0.056888185,0.06126482,-0.01948417,-0.028419571,-0.07338031,-0.0644045,-0.0462911,0.012358874,0.07428948,0.054642793,0.022586204,0.07563227,-0.01026572,0.068996824,0.0016538627,0.06931668,0.010399206,-0.06248429,0.036635596,-0.07129137,-0.0007629214,-0.019255828,0.08419719,-0.022605905,0.09908665,-0.06547303,0.031625956,-0.06597531,0.04362701,-0.04612708,0.025420735,0.041657805,0.06634989,0.04347973,0.083085,-0.034738876,-0.016522322,0.048983496,0.0073283375,-0.07017647,-0.1529285,0.028619282,-0.045652464,-0.010306572,0.060197968,-0.0044181263,0.0017148909,0.012077735,0.0038416032,0.031653915,-0.028215919,0.012148047,-0.05742829,5.6837147e-33,0.00623847,-0.024874395,0.10019485,-0.06851172,0.013584211,0.04066147,-0.07116552,-0.06824861,0.043622572,-0.035986684,-0.15169539,0.09012121,-0.09735504,0.054019846,-0.05335736,0.103810534,0.009772973,-0.04891704,-0.0031736966,-0.046408374,-0.029640565,0.084004276,-0.0452188,-0.043164525,0.08427713,0.0051144897,-0.0370217,0.037044305,0.053913612,0.0063744504,0.026888344,0.04551146,0.036870793,0.07220147,0.025377404,0.070948005,0.023876162,-0.024143726,0.004809457,0.00077468046,0.074113555,-0.018999629,-0.007891926,-0.0113111045,-0.020840587,-0.013123456,0.0027594122,-0.0012958229,-0.11135286,-0.027387826,-0.016171038,0.028652737,0.0044309143,0.029418653,0.0067295814,0.0017504398,0.019277755,-0.013229496,0.12053017,0.08907964,-0.029996177,0.037659697,-0.030129604,-0.032281026,-0.009173404,0.06296433,-0.06680253,-0.018773638,-0.0453915,0.011995244,-0.034131438,0.016554844,0.041568875,-0.016670115,0.05920221,-0.064453304,-0.08735476,-0.0028209772,-0.024614366,0.047940966,0.06353374,-0.03636881,-0.02654198,0.033141144,-0.08285533,0.040245995,0.022942824,-0.08535305,-0.045336798,0.029767696,0.05035234,-0.0049048536,0.012310772,-0.028716756,-0.013455593,-6.609118e-33,0.091284126,-0.004663664,0.0810857,0.012559987,-0.00047116255,-0.021253925,-0.0077122864,-0.010035431,-0.012048979,-0.028440813,0.07937519,0.00627696,-0.03002065,-0.078237735,-0.07412816,0.05225005,-0.006332965,0.06592885,0.022261193,0.02371292,-0.12465054,0.037450187,-0.0105482,0.00962161,0.054006815,-0.030965103,0.037481055,-0.0015535896,0.0137747675,0.028095977,-0.07062433,-0.0074359197,-0.043490216,-0.1141764,-0.023741437,0.00018937756,-0.008377348,-0.040853593,0.035074066,-0.05286874,-0.017639317,-0.0029142392,0.06411438,0.029071074,0.028568063,0.11225424,-0.08885736,-0.04819493,-0.10990529,-0.015735203,0.05310049,-0.01135511,-0.0013175556,-0.008380254,0.08715573,0.03275019,-0.003716985,0.058228627,-0.023098925,-0.04672562,-0.021061836,-0.018670384,0.01302325,0.033358723,0.057993114,0.093198195,-0.042313643,0.042277876,0.008352866,-0.021111893,0.058917906,-0.023699116,0.02327608,-0.04236348,0.065454856,0.029663945,-0.12353461,-0.10163716,-0.067361996,-0.089914024,0.07828592,-0.009727285,-0.015721591,-0.053624023,0.036717955,0.023741227,-0.04138206,0.0791188,-0.058208503,0.07608828,0.024719711,0.011909958,-0.061191987,0.109124295,0.054428767,-4.762278e-08,-0.0365262,-0.06756163,-0.028923824,-0.120390974,0.02453797,0.050454833,0.012188937,0.10029987,0.058226515,0.019304333,-0.008802331,0.048111107,-0.045153603,0.017773226,-0.027584262,-0.0047274823,0.01425131,0.030501137,0.006382584,0.03898276,-0.09485026,0.08595092,-0.08808704,0.069444634,-0.07641088,-0.008927255,-0.007998522,0.053047657,-0.04670111,-0.026355842,0.022932801,0.003042613,0.0012398108,-0.058024906,0.012176796,0.04029546,-0.10890316,-0.029079603,-0.04982854,-0.044096835,0.064023346,0.028260928,-0.06649861,0.020751478,-0.007892386,-0.05823039,-0.003846657,0.05194887,-0.009315995,0.055156782,0.048225075,0.0140411705,-0.022940759,-0.14904547,-0.0845275,-0.02732954,0.054157488,-0.029033307,-0.02370043,-0.028002968,0.018302461,-0.028688831,0.08672575,0.037576623 +3.2.1.133,Acts on starch and related polysaccharides and oligosaccharides. The product is alpha-maltose; cf. EC 3.2.1.2 beta-amylase.,384,1.0,0.012605059,-0.118785664,-0.05258945,0.0146413315,0.02370819,0.06444074,0.091034114,-0.048605185,0.050655555,0.018425094,-0.0033482483,0.017836696,-0.12365767,0.015912749,-0.07288404,0.03800066,-0.006670509,-0.030700952,-0.0031028541,-0.003488304,0.06870416,-0.026419565,0.016724955,0.06852862,0.048533753,0.0024159753,0.025057128,-0.04856337,-0.03286277,-0.07375484,0.004842516,-0.07240473,0.084108196,0.050182637,0.020115389,0.05323965,-0.022926958,-0.07989322,-0.018849619,-0.025948672,0.05764411,-0.095590256,0.043289796,0.0025650468,-0.07447433,-0.026501868,-0.09725485,-0.012864303,0.022385413,0.032493334,-0.09878465,-0.112998955,-0.048894454,0.041954115,0.07968968,0.055993836,-0.025275704,-0.01895534,-0.05233862,0.07737525,0.0011755783,0.062323973,-0.001674394,0.017830338,-0.01577988,-0.026924793,-0.0015336926,-0.0615193,-0.050785966,-0.037325725,-0.07772044,-0.028414825,-0.028734978,-0.01991704,0.07326174,-0.053945284,0.0028497672,-0.0612313,0.040096417,-0.011257264,0.0139895715,0.011532285,0.044415284,0.074012615,-0.051884457,-0.077158906,0.004617447,-0.024976017,0.05537469,0.007478628,0.016799092,-0.021392787,-0.037942186,0.016778896,0.013716255,-0.011607327,-0.007793925,-0.099865444,0.10177359,-0.00071356195,-0.08177617,-0.0015220555,0.025383957,-0.086240135,-0.0979123,0.093625434,-0.0073414026,0.024244763,0.025661547,0.07137256,0.02014182,-0.011854576,0.026911631,0.0049363496,-0.080249555,0.047042802,-0.0040538614,-0.08230448,0.009473325,-0.081640445,0.020741025,0.0056002573,0.13560243,0.045771256,-0.080727756,0.059779655,-0.060768116,-1.407931e-33,0.046012986,-0.01976665,0.021244975,-0.018621473,0.0020977939,-0.0067671007,-0.000846142,-0.015294311,-0.03306531,-0.020265806,-0.03198001,-0.0559685,0.034235734,0.07012518,0.077286564,0.023908032,-0.0029483768,-0.047872066,0.039631173,0.06303559,-0.0049913675,0.08294352,-0.037268374,-0.020281984,0.010907512,-0.010766714,-0.0733716,0.029599579,0.026083106,0.0054815165,0.1169,0.046005946,-0.10376944,0.028237132,0.04800126,0.08876914,-0.05098784,-0.0006539297,0.021267159,0.012522588,0.05269813,0.024612278,0.010919379,-0.07546853,-0.009474745,-0.038006835,-0.011597464,0.069738545,0.051167857,0.055638656,0.07420783,-0.031584803,-0.0013540242,0.067190535,-0.010278659,0.05661213,-0.044204947,-0.008922776,0.019098582,0.071064316,-0.023809282,0.013721952,0.06497273,-0.049571794,0.0103574665,0.017233238,-0.030431341,-0.005478299,-0.07053393,0.016909413,-0.06272709,-0.040797036,0.070308596,-0.0472443,-0.03763651,-0.061568987,-0.06310281,0.04104773,-0.017213702,0.009067527,0.016471764,-0.05353848,0.07126155,0.00061706314,-0.09783143,0.022300879,-0.021959584,0.009931547,-0.05218885,0.038885858,0.011710702,0.0018868287,-0.0018268942,0.08760242,-0.015570427,-1.7126444e-33,0.097328104,-0.15900558,0.04131615,-0.028402032,-0.026747752,-0.0012770921,0.02821531,-0.06376657,-0.004435061,0.04848653,0.040552188,0.033706494,0.006463635,-0.097656496,0.0051111165,0.010398004,-0.03418278,0.12427593,-0.023497293,-0.0057390127,-0.0063079325,0.1424359,0.015723463,-0.00868557,0.038443077,-0.056392334,0.06575392,0.045588538,-0.0121529875,-0.01573694,0.007602998,-0.03737284,-0.022487968,-0.067450784,-0.06234532,0.016755853,-0.063658945,-0.06023551,-0.0038144249,-0.02477254,0.035372626,0.036737893,0.008464692,0.04643489,0.05127517,0.08364568,-0.06467267,0.020480573,-0.043403685,0.0019653374,-0.01167736,-0.044611763,0.025660016,0.009722867,0.003606701,0.096963026,0.03357172,-0.0076155798,-0.004846267,-0.056623306,-0.020891286,0.07140797,0.06504087,-0.0365524,0.067218445,-0.0043756254,-0.06529711,-0.00021396867,0.08827228,-0.0031463066,-0.005099355,-0.00048096015,-0.046993,0.10123611,0.003939723,-0.05276343,-0.11749852,0.0049203676,-0.008053907,-0.026786856,0.035509925,0.021620777,0.030881392,0.0021675332,0.0055569503,-0.02122266,0.055043254,0.091987625,-0.052101735,0.030984329,-0.04619404,0.024815524,-0.013939958,0.017762996,0.079990484,-2.9390538e-08,0.03014025,-0.060845293,-0.030126136,-0.05361554,-0.053160798,-0.008477971,0.018622525,0.039071172,-0.021481551,-0.0074183787,-0.05115685,0.14084563,0.015692243,0.057461366,-0.012839989,-0.060291246,-0.00045656256,-0.00044874282,-0.054071117,0.0025258232,-0.10025914,0.014134018,-0.025584815,0.014019521,-0.09563137,-0.07068449,0.043986145,0.07675301,-0.07238813,-0.040137134,-0.010856054,0.086880475,0.00795673,-0.08611552,0.016609734,0.060109716,0.0068782377,-0.078308865,0.020238096,0.039129287,0.027171345,-0.042098112,0.01954578,-0.058350887,-0.03696206,0.018447729,-0.037668947,-0.03350787,0.022216776,0.06475041,0.038930975,0.050177142,-0.1054812,0.0022935697,-0.034590762,-0.0012766192,-0.050241176,-0.033630397,0.09410391,-0.04696004,0.110000215,-0.026573777,0.12985148,-0.037901588 +3.2.1.134,"The enzyme participates in an inulin degradation pathway, hydrolysing the product of EC 4.2.2.17, inulin fructotransferase (DFA-I-forming).",384,1.0,-0.033430435,0.02233968,-0.06845685,0.0037010524,0.120234035,-0.013184092,-0.031714328,0.07526064,0.0071690185,-0.033875663,-0.029113112,0.004054612,-0.02050146,0.03321312,-0.06787604,0.025994034,-0.094010964,-0.002553947,-0.061065078,-0.069656424,0.042988665,0.010812457,-0.036268603,0.019232035,0.0061850226,-0.024480835,-0.004990111,-0.034722026,0.064675234,-0.09235076,-0.0012290427,0.004145121,0.011826969,-0.073262595,0.043879677,0.10475319,0.026774859,-0.06834092,0.01053563,-0.05688077,0.093081675,0.04319196,0.01654337,-0.053447366,0.055360522,-0.016405653,0.024395728,0.027724696,0.022704747,0.04010218,-0.0049899565,-0.034659937,0.030060668,-0.00067592843,-0.026404656,-0.022335717,-0.048202205,-0.011193286,-0.050068,0.082351714,0.057973936,-0.003526168,-0.005793437,0.000612628,-0.0038167436,-0.047059625,0.010851139,-0.043001384,-0.051839072,-0.0141596105,-0.083804324,-0.07129783,-0.020775195,0.10472302,0.07498916,-0.04375126,-0.031548593,-0.039469436,0.06859513,0.022349237,0.078314,-0.009033267,-0.01340488,-0.0005752238,0.015861385,-0.03525611,0.049141206,-0.0630952,0.035855904,0.05784205,-0.004147903,-0.058830313,-0.018937398,0.050615624,-0.0726119,0.061408862,-0.019321637,0.074151084,0.06342779,-0.001170567,-0.0078047356,0.011715605,-0.091607,-0.033686034,-0.056430135,-0.03320185,0.0084852,0.1054988,-0.00021929425,0.04058596,0.025329389,-0.09403261,0.06467849,0.063973874,-0.03498332,0.09913037,-0.01774515,-0.045445785,0.003974324,-0.023435615,0.04575746,0.008847819,0.10479087,0.06538173,-0.07309705,0.05783336,-0.06717287,-1.5520838e-33,-0.006784955,-0.04415223,0.028959768,0.020677058,-0.03995809,-0.044665445,-0.07458126,0.018650757,-0.018442424,-0.051051274,-0.06330851,-0.09010223,0.036221363,0.035877533,-0.03666267,-0.081232965,0.0738062,-0.060274538,-0.009857722,0.013936529,0.045472756,0.05769055,-0.051743396,0.02338461,0.047658898,0.04813771,-0.022032926,0.05779851,0.030347802,-0.006202609,-0.0069657005,-0.102301955,-0.13850777,-0.0009107946,0.04808381,0.0010252858,0.032701388,0.0058535053,0.0119363805,0.074890345,0.010427868,0.0045207576,-0.00048697277,-0.09028421,0.02603216,0.014550572,0.032155585,0.09001197,0.03971649,0.014727805,0.040492907,-0.045327693,0.06185102,-0.028383419,-0.07798645,0.039323956,-0.01741456,-0.09293976,0.034087308,0.050828714,-0.07693505,0.03667718,-0.073541336,0.06994579,-0.03959318,-0.021258337,-0.018827857,-0.027031543,-0.03342176,-0.0044218707,-0.10402105,-0.0037479033,0.06744311,-0.014318427,0.07337829,-0.082469754,-0.06945132,0.06286528,-0.021449715,0.0020145571,-0.03785298,0.07997991,-0.023914,0.0063871937,8.697324e-05,0.022493752,0.012909155,-0.03496715,0.053640872,0.03428349,0.00059064425,-0.043604765,-0.025042739,0.06178526,0.018734986,-1.366408e-33,0.05937857,-0.053204954,0.032586128,-0.051305722,-0.010505784,0.036705155,0.06740988,0.04530896,0.111022644,-0.01285961,0.023020323,-0.04199981,-0.019849434,-0.051922366,0.0676226,0.004562724,-0.08078778,0.05497883,-0.025131417,-0.03429573,-0.04799884,0.063643225,-0.012332922,0.010810621,-9.061249e-05,0.018867774,0.009913922,0.031116745,0.10575396,0.055766053,-0.082525335,-0.041819807,-0.04045064,0.023674885,-0.06548876,0.0124423355,-0.035440665,-0.050391015,-0.03682201,-0.03634747,0.03672467,0.1122353,0.0029245883,0.06001765,0.061437774,0.06698992,-0.0664649,0.07507983,-0.048243254,-0.015366108,0.045858596,-0.013147177,0.0032476853,0.061455023,-0.056291558,0.0040945457,0.06829062,0.08775653,-0.017569905,0.04396897,-0.026779152,-0.11193574,0.015680114,0.0038209893,0.05222758,-0.037580885,-0.040608708,0.07079086,0.0069185123,0.04030934,0.052700724,-0.020512305,-0.037310716,0.046669096,0.01370947,-0.026350847,-0.14870697,0.0012653216,0.028353296,-0.009133345,-0.04526517,0.021344924,-0.046280652,-0.049502783,0.028341066,-0.082544066,8.284114e-05,0.10442922,0.05270736,0.023004705,-0.031226033,-0.075716965,-0.085252166,0.0695772,-0.00013312261,-3.071288e-08,0.008360774,-0.064556904,0.022565693,-0.03653047,-0.022746217,0.021329468,0.04583634,0.061544966,0.09625117,-0.0409488,-0.019574134,0.07528884,-0.026466746,-0.06562626,-0.0052257264,0.06338265,-0.034927126,0.045113187,-0.0006261033,0.048133574,-0.024720224,-0.06177642,-0.11179319,0.04075337,-0.008978248,-0.075280726,0.058448575,0.09117416,-0.038115803,-0.02754616,-0.023882821,0.046559185,0.029237997,-0.036890835,-0.11218923,0.010109787,-0.010848682,-0.060006127,0.015806196,0.09343735,-0.004808569,-0.0054422873,-0.04607742,-0.04831638,8.913194e-06,0.017386518,-0.0119952755,0.0027834992,-0.0008558568,-0.012351088,-0.01541993,-0.03348536,-0.028218014,-0.047658723,-0.057202302,-0.052384887,-0.024450071,-0.035893325,0.023169715,-0.04568423,0.031696875,0.039890125,0.22487596,-0.009044109 +3.2.1.135,cf. EC 3.2.1.41 (pullulanase ) and EC 3.2.1.57 (isopullulanase).,384,1.0,-0.0640978,-0.09231478,-0.06322829,-0.020794356,-0.06127663,0.01438912,-0.04059732,0.04799554,0.045062598,-0.052299783,0.15648149,-0.14758731,-0.05365076,-0.007528905,-0.03505315,-0.02899744,-0.005312038,0.012033287,0.02786191,-0.00096008764,0.03035085,0.10456587,-0.0264257,0.0082576675,0.016032344,0.011710958,-0.037670318,0.03507553,0.009594698,-0.15110976,-0.05983528,-0.078547955,0.027507696,-0.09544385,0.01948849,0.0033078776,-0.04235265,-0.06656776,0.06538454,0.118503064,0.038598616,-0.07004151,0.10982474,-0.029581428,-0.101997666,-0.0036661536,-0.020183545,0.019311214,0.04722122,-0.03625083,-0.034860723,-0.081680454,-0.0751447,0.06234066,0.040061865,-0.014924217,-0.038584743,-0.022889161,0.02377244,0.04087594,0.043526143,0.012738908,-0.013123906,-0.0020682365,0.012670368,-0.021142052,0.048205733,-0.060865268,-0.014314889,0.01644875,-0.07613075,-0.006313316,-0.01297107,0.0833073,-0.023682913,0.04507209,0.006276971,-0.05999932,-0.0015360586,-0.09239605,-0.06098139,0.0075047757,-0.03524932,-0.019457797,-0.054369416,0.0032555356,-0.0066472427,0.07667947,-0.028526649,0.007882079,0.0859214,0.028889002,0.05028978,0.03847731,-0.017987227,0.055608593,-0.017297639,0.09816134,-0.0030065398,-0.06524289,0.027161466,0.076755874,-0.05584349,-0.05695058,-0.06232367,-0.04084211,-0.009403503,-0.019002175,0.04209982,0.043952573,-0.04972344,-0.016342022,-0.0078017185,-0.076127194,-0.076807275,-0.023043208,0.06904658,-0.024454694,-0.0019373863,0.019131927,-0.00632569,-0.06343794,0.049332034,0.00045337042,-0.06304919,-0.024275245,-0.054419067,-1.8717437e-33,0.005131823,-0.010852785,0.018790495,0.051811088,0.023500588,0.0062238025,-0.09933249,-0.078368425,-0.012431763,-0.036082696,-0.1408466,0.020826163,-0.09058341,0.06667455,-0.0050549586,-0.03963874,-0.0065510278,0.017794002,-0.06616912,-0.0030890205,0.0555876,0.084281676,-0.020530183,0.019373432,0.059437938,-0.008838289,-0.017337736,-0.0177704,-0.029224174,0.00039166835,0.04215381,-0.112386815,-0.05774115,-0.014648574,0.039506856,-0.025001265,0.0044401507,-0.057355776,-0.04622397,-0.040210616,0.0477543,0.06617832,0.017336829,0.014110355,0.06006595,0.007816754,-0.035016406,0.057106048,0.11422926,-0.012002651,0.05403488,-0.021382349,0.057079595,-0.056524593,0.015209693,0.0074144886,-0.009055903,0.10549788,0.014833742,0.10975297,-0.02283885,0.17434476,0.03636978,-0.018855067,-0.015835915,0.10359293,-0.15126319,-0.01668858,-0.002024815,-0.02371254,-0.07158858,-0.047782574,0.050810795,-0.002071628,0.034240853,-0.05989996,-0.09699936,-0.0052433675,-0.024582908,-0.025374321,-0.058881044,-0.0025852846,-0.001760215,-0.013534454,-0.06545994,0.058418605,-0.02407908,0.063565105,0.03921597,0.07633347,0.05297097,0.018128028,-0.015607751,0.033016,-0.01463355,-4.1642696e-34,0.044835057,-0.047678877,0.022748219,-0.021711167,0.02065012,0.07588346,-0.0112236,0.07910234,0.028725395,-0.05535705,0.07031832,0.0035532527,-0.008619231,-0.048713222,0.059630767,-0.011501747,0.024846572,-0.0099001005,-0.073342524,-0.027269447,-0.058120213,0.050933223,0.026465457,0.083955854,0.024250817,0.015414894,0.05990822,0.008393418,-0.02815592,-0.00045194794,-0.024506273,-0.04638143,-0.07100605,0.05928604,-0.12990528,-0.036653653,-0.012372308,0.022157408,-0.015621283,-0.033199146,-0.012891643,0.034589455,-0.022607923,0.104256056,-0.04000319,0.05697598,0.0364228,-0.041085027,-0.03743387,-0.012664653,-0.0028429336,-0.021833338,0.029770665,0.03148526,0.023544546,0.026207756,-0.043108683,0.038829442,0.024238862,-0.013517058,-0.051624436,0.009314573,0.027203891,-0.021025432,0.10309261,0.05182602,-0.089932345,0.022094509,-0.05681202,0.016610965,0.049744807,0.004811613,0.030721005,-0.062076796,0.007076381,0.040925473,-0.040759478,-0.042025264,-0.01512108,-0.009599736,-0.03300268,0.0028754415,-0.015497958,0.033325583,0.036399264,-0.03893708,0.05663729,-0.0012023506,-0.007218306,0.012046995,0.016215168,-0.016047899,0.035382297,0.06184075,0.07512045,-2.8814982e-08,0.05313631,0.019579487,0.03180899,-0.05104832,0.037779853,0.022546122,-0.028609376,0.05594537,0.043502104,0.039796673,0.027066275,0.04166782,0.058749452,0.09205299,0.03486453,-0.046285633,-0.0155345835,0.12161121,0.024256919,-0.0042953505,-0.08174234,-0.033556364,0.0060366397,0.004503705,0.017937355,-0.024727294,0.094806254,0.035438135,0.025651349,0.0017786652,0.038851846,-0.0038647056,-0.008418541,-0.028578483,-0.030406335,0.0851156,-0.049299914,0.045648802,-0.08355796,0.0645341,0.062360883,-0.102615066,-0.082264476,0.011368574,-0.007513599,0.033364046,-0.044545863,0.124376334,-0.02397288,-0.053784475,0.007116172,-0.049276292,0.03644337,-0.045721587,-0.031585798,-0.0048407093,-0.035481084,0.0045793937,-0.038046297,0.059394058,0.0333709,-0.027863706,0.10209379,0.06781542 +3.2.1.136,High activity towards feruloylated arabinoxylans from cereal plant cell walls.,384,0.99999994,-0.039708618,-0.045073986,-0.095964834,-0.019473027,0.011767838,0.038604714,-0.035974525,-0.047039088,0.02504595,-0.006207311,0.06514894,0.030590324,0.035308152,-0.029265974,0.01935964,-0.010311894,0.03853287,0.11935693,-0.07703041,-0.048634153,0.060202885,-0.004410625,0.043567307,0.0035114838,-0.016048353,0.0040411316,-0.034685962,-0.009892747,-0.08177966,-0.08710579,-0.047457963,0.06496901,0.02418857,-0.014607643,-0.040447287,0.068947926,-0.062660486,-0.07543485,0.10215024,-0.058651634,-0.011554043,-0.104520835,0.07333839,-0.053339504,-0.08991076,-0.08108964,0.045441683,0.011749216,0.086422704,-0.015593761,-0.016939333,0.020978943,0.030927425,-0.036805637,-0.008268297,0.016542686,-0.0048803184,0.035978556,-0.032200795,0.04356214,-0.014842514,-0.0025860595,-0.02094557,0.0061575114,-0.15907931,0.0104066655,-0.027879305,-0.0049361787,0.02954892,0.010910194,0.010819743,-0.008290218,0.078386344,0.017117148,0.003917582,0.027367078,-0.02405173,-0.07830846,-0.009181001,0.05315492,-0.0060663773,-0.01305768,-0.023836192,0.042188738,-0.029604508,-0.029136987,0.012458347,0.04059219,-0.0026230796,0.063479096,0.096631885,0.05038133,0.017515395,0.0777486,-0.0046673073,0.009707,0.02891041,-0.03450968,-0.06812091,-0.04473815,-0.011803786,-0.04840204,-0.015958928,-0.04746784,0.0058601312,0.011305975,-0.0101295,0.0027238317,-0.06546504,-0.009921326,-0.018784933,-0.016762229,-0.037221145,0.013440283,-0.11148168,0.00084826833,0.058968946,-0.10575817,-0.026364645,-0.021855794,-0.0015578723,0.017625345,0.045762774,-0.02185691,-0.018924644,0.0028958316,-0.073085524,4.2914326e-35,-0.0004066354,0.0296267,-0.03198971,0.009569314,-0.017771456,-0.060216624,0.0014373614,-0.034445282,0.030274067,-0.019108206,-0.12232703,0.0086869635,-0.011583162,0.026424091,-0.00903086,-0.021602567,-0.030025532,-0.06304714,0.060400065,0.04143849,0.021915283,-0.0047060577,0.0124201,-0.067203134,-0.06900972,0.019406762,0.045470886,-0.03956825,-0.03127342,0.03406064,0.06448724,-0.038513683,-0.013451631,0.015805745,0.06776096,0.047983743,-0.072361335,0.000737586,-0.03805282,0.0037410452,-0.05078704,0.03731247,0.031958085,-0.052617397,0.023187216,0.029738722,-0.040553175,0.13763487,0.009153858,0.05325671,0.09789341,0.015176084,0.007944072,0.04600815,0.022722023,0.03779203,-0.026470257,-0.027491644,-0.050086837,0.0880159,-0.036778763,0.0062563024,0.011183313,0.004554514,0.021111768,0.06653618,-0.11029922,0.040070243,-0.03602595,0.06825362,0.067877404,-0.04444432,0.03903734,0.07546978,0.052525293,0.08812358,-0.0037712746,0.049677867,0.0030663095,0.0757366,0.14807378,-0.0034114644,0.03386888,0.0026609965,-0.17714614,0.09028116,-0.016682003,0.041122194,0.025032416,0.017666593,0.10448247,-0.06537205,0.011295695,0.025497966,-0.009619144,-2.0230133e-33,0.10124124,-0.020366983,0.05345497,-0.045954477,-0.035848532,-0.024055352,0.008547853,-0.005465285,0.037624385,0.10525113,-0.0022925697,0.06478076,0.018368995,-0.06443794,-0.039424423,-0.0018752741,0.10694741,0.0075846286,-0.056613717,-0.017648676,-0.16785648,0.03185401,0.016036408,-0.0064688884,0.008412554,-0.049662046,0.024613027,0.0022343847,-0.04832217,0.024320727,0.018012011,-0.038301278,-0.049910128,0.018753327,0.059571613,0.016819559,-0.067976736,-0.052021243,0.061015923,-0.036720257,-0.027699612,0.04982128,0.034426983,-0.035031635,0.057050508,-0.014677687,-0.075073086,0.005248272,-0.072237104,-0.03990902,-0.084380984,0.078516714,0.01047246,-0.03212217,0.06934174,0.02567488,0.043689273,0.012159416,0.034706708,-0.014188745,-0.031345766,-0.02390853,0.0408316,-0.045099627,-0.011474623,0.052200325,-0.03685292,-0.016451992,0.054968935,0.09946706,0.058028102,0.06541358,0.00986692,0.030263085,-0.052620776,0.045325257,-0.0056737247,-0.050235227,-0.10817884,-0.0079690935,0.11794771,-0.021967364,-0.036988202,-0.062461365,0.033070643,-0.022137111,0.014096659,0.09517785,0.046032026,-0.006589906,0.024633376,-0.06750802,-0.0466947,0.028412158,0.089923054,-2.0730258e-08,-0.09648572,0.0037393281,-0.015132526,-0.040822737,-0.031805743,0.05982783,-0.039493136,0.015231327,0.1112427,-0.09635932,-0.050924223,0.10283074,-0.03488402,0.069772266,-0.08068363,0.0086058285,-0.011851092,0.0029628982,0.04296709,0.040599953,-0.112422705,-0.03021975,-0.126385,0.030916415,-0.019661963,-0.032571655,0.00997989,-0.025342077,0.08108387,0.012417064,0.030583423,-0.040807635,-0.03501673,-0.058301926,-0.024101676,0.0073736976,-0.0012738616,-0.00914733,-0.025960878,0.028889721,0.010613889,-0.09946565,0.024465492,-0.012811021,-0.022442473,-0.02884119,-0.07526555,0.049756426,-0.0665179,0.04375929,0.12174891,0.000565577,0.015787628,-0.031871643,-0.015683876,-0.049609296,0.038432263,-0.027430445,0.029998176,0.031083524,-0.06513477,0.0010397545,0.094779134,0.05053798 +3.2.1.137,"Mannose residues linked alpha-D-1,3- are also released, but very slowly.",384,0.9999999,0.024096504,-0.06880538,-0.013367196,-0.055042725,0.08333533,-0.018447747,0.0383857,-0.0030526398,0.028812503,0.13151732,0.07796895,0.012722618,-0.11220566,0.0024718558,-0.019060977,-0.017281568,-0.05075038,0.0041250726,-0.046641435,0.045220427,0.04665463,-0.016260227,0.030485447,0.012075312,0.068270184,0.026357295,0.0096882805,-0.062800385,0.07910741,-0.14430603,-0.033699792,-0.043796293,-0.037511136,-0.018035652,0.12096917,0.04485481,0.021440076,0.020735499,0.008710381,0.013956266,0.06371991,-0.036768924,0.027314821,0.017546805,-0.0770694,0.04875737,-0.12633665,0.059110515,0.0076358933,-0.011570014,0.017323107,-0.027012285,-0.021167835,0.051381465,-0.03128042,0.030541636,0.0038738786,0.009825198,-0.049817815,0.06114237,-0.019573972,0.0074620885,0.034853615,-0.05060709,0.09261177,-0.025810067,0.04869859,-0.12004914,0.03518106,0.012331111,-0.030911008,-0.012170507,-0.06562312,-0.061894566,0.012394027,0.018249799,0.04726438,-0.1306284,0.030657435,-0.039643742,0.040291958,0.027104262,0.086363494,0.057364672,-0.052691527,0.043586385,-0.024610793,0.0058841957,0.009728594,0.029966092,-0.0037502458,0.0713124,0.0486103,-0.004225478,-0.0031325347,0.050642904,0.04010491,0.07636601,0.019277357,0.010463271,0.01729437,0.09976821,-0.07115994,-0.084903836,-0.090086445,0.009135549,-0.014076101,0.015147439,-0.05897537,0.030573308,0.023122668,-0.018464446,0.059752557,0.014097219,-0.108214594,0.050093547,0.008631606,-0.0059843347,-0.016331812,-0.03289381,0.039834823,0.022652397,0.03691598,0.019835161,-0.09401373,0.038251925,-0.0027728346,-2.0308593e-33,0.05812955,-0.00135224,-0.027150286,0.045269467,-0.06945941,-0.013295388,-0.08155969,-0.07207111,-0.06368106,0.013867304,-0.12143175,-0.09605539,-0.034596264,0.007964024,-0.060885955,-0.061408382,0.028421814,0.044497766,-0.029531738,-0.009030776,0.051174324,0.08654828,-0.030705843,-0.0055006756,0.11132521,0.05349881,-0.08365078,0.06607527,0.052595057,0.0016172688,0.052059326,0.07130865,-0.11782886,0.0062914905,-0.019944485,-0.016162748,-0.05828588,0.032392967,0.005459511,-0.011146031,0.0246439,0.02015311,-0.009480045,-0.023635,0.03386521,-0.07447898,0.012627736,0.056529395,-0.029456606,-0.031656567,0.041572988,0.01381642,-0.031855557,0.020514488,0.00015744662,-0.038135473,0.006978745,-0.08121496,0.036824875,0.106393754,0.02573131,0.10148933,-0.05263614,0.022671996,-0.0005649811,0.02731263,-0.054510873,0.025824398,0.02341066,-0.010957828,-0.032455713,-0.0073529044,0.11573902,-0.10542708,0.056318216,-0.04303876,-0.053871937,-0.0010679117,-0.02300579,-0.00942699,0.05077494,-0.054957505,-0.016677847,0.0054730633,-0.06187161,-0.02967639,-0.016070815,-0.06711704,-0.039368447,0.0005612924,0.026306948,-0.0373595,-0.072704926,-0.02955589,-0.066673316,-1.4373929e-34,0.045350093,-0.0784153,-0.00068198645,-0.0019298765,-0.05628144,0.05316571,0.058974504,0.065386176,0.0347963,-0.024530968,0.050790466,0.023477325,-0.08914134,-0.039198264,0.015256412,0.0019153397,0.033333387,0.056752816,0.041850086,0.01987003,0.00998851,0.067451015,0.0037066666,0.06633635,0.06221276,0.011521472,0.052127633,0.005036233,0.0008410469,0.06364412,-0.009548042,0.024663797,-0.0073338267,-0.047685545,-0.022879172,-0.01919558,-0.016766312,-0.026592823,-0.044975545,-0.006198407,-0.06895911,-0.003272992,0.050795466,0.027711825,0.057774235,0.050626032,-0.04667379,0.033028174,-0.048654627,0.07632909,-0.00014476823,-0.0692037,0.004189692,0.006161867,0.010436585,0.046062518,-0.039242487,0.018613191,0.01161185,0.06632789,-0.00038572194,0.018460194,-0.008919852,-0.03136042,0.091335155,0.019917931,-0.03752608,0.035792593,0.06289305,-0.010283763,0.05528515,0.052211277,0.04126386,0.001449111,-3.9211347e-05,-0.045368817,-0.10638008,-0.052667584,0.057654887,-0.06069547,-0.081263684,0.062279765,-0.005774154,-0.017556613,0.045985572,-0.089593776,0.031286057,0.059923556,-0.029720986,0.042907678,-0.05931916,0.01710756,0.00799297,0.10310216,0.09150966,-2.3516373e-08,0.12432439,-0.019662531,0.021340622,-0.051901296,0.035714563,0.034295406,-0.0040837396,0.102767386,0.019220844,-0.04907753,-0.00046370586,0.10216255,0.055752575,0.00015952789,0.07024365,-0.008585437,-0.046484414,-0.021441145,-0.07802646,-0.10904649,-0.078827664,0.040113084,0.00905256,-0.08808367,-0.082205884,-0.03393345,0.052321207,0.031764526,-0.09468733,-0.027502531,0.025582753,-0.003906829,0.033913303,-0.09824308,0.00830477,0.08380534,-0.0617116,-0.06620156,0.044031892,-0.010451087,-0.02807498,-0.040092133,0.009350911,0.0002650117,-0.05149431,-0.026051905,-0.074900806,-0.0055735665,-0.021848897,0.05391109,-0.012535093,0.01988076,-0.09919156,-0.034427088,-0.056448884,-0.0314122,-0.02358765,-0.031466335,0.06437787,-0.071880564,0.042586,-0.08498517,0.09045995,-0.016811782 +3.2.1.139,Considerable differences in the specificities of the enzymes from different fungi for alpha-D-glucosiduronates have been reported. Activity is also found in the snail.,384,1.0,0.018309107,-0.077870466,-0.04316671,-0.0025066577,-0.04899136,0.012467519,-0.07914915,-0.0031425112,0.032633692,0.0672801,0.07481388,0.0064838305,-0.08374107,0.05801166,-0.08946712,-0.033125326,-0.00646377,0.012628878,-0.07010572,-0.03780753,0.0533478,0.027884675,0.011051635,-0.058372222,0.046421845,-0.0758555,0.049104646,-0.047688335,-0.04744242,-0.06885841,-0.08942633,-0.039032124,0.04345816,0.02535371,0.07297251,0.047945857,-0.08027438,-0.0027240473,0.07505082,0.060571462,-0.02583306,-0.118906885,-0.022432175,0.044922855,-0.11167072,-0.0028854157,-0.06584331,0.029511523,0.007642421,0.032394387,0.021793619,-0.04877826,0.007352239,-0.045841612,-0.019517947,0.00038120753,-0.021583565,0.045318384,0.011795237,0.04309621,0.026430482,0.04467297,0.037812132,-0.0023823525,-0.07271108,-0.019257624,0.040425178,-0.044353325,-0.06718444,-0.071905814,0.021984275,-0.03230175,-0.020076543,-0.0789132,0.024822868,-0.011539171,-0.043930206,-0.070058525,-0.011456327,-0.044708114,0.10859749,0.088765986,0.07390572,0.03185335,0.0009995756,0.05097064,-0.026386984,0.03777805,-0.055329114,0.025455892,0.06597255,-0.057018507,-0.033454124,-0.011433061,-0.008026498,0.036023602,0.029144876,0.045795605,0.02542663,-0.0677819,-0.020121224,-0.025123525,0.038427584,-0.00961515,-0.028069446,0.049580548,0.025752146,0.021379024,0.035667956,-0.032843832,-0.025171624,0.0581973,0.01382545,-0.015068804,-0.011534272,-0.016219836,0.05660003,-0.0012484597,-0.020003267,-0.016112,0.019965382,-0.027663874,0.049946863,0.011143378,-0.04351013,0.07025271,-0.03510738,-2.235276e-33,0.088247105,-0.0042421697,-0.10570645,-0.033244587,0.0043321606,-0.01307169,-0.002005599,0.004166558,-0.0073862905,0.020100528,-0.13754839,-0.015609625,-0.07124438,0.08506614,-0.0007285114,0.13441388,0.037443202,-0.060958236,0.0637135,-0.025505727,0.076437324,0.016310178,-0.030541992,0.015909646,0.050889585,0.041745484,-0.04432389,0.025263255,0.030712826,-0.056511126,0.023767386,-0.10783274,-0.038078852,0.05727519,0.03180397,0.041503523,0.017931178,0.008126676,-0.008243044,-0.08904869,0.022845816,0.014542997,0.0105694095,-0.093269035,0.050476465,-0.00039154355,-0.05216788,0.035781883,0.014763975,0.04275072,0.074892804,0.06583715,0.10394875,0.062434256,0.01955373,0.011733856,-0.044183552,0.00023089134,0.044042993,0.07781945,0.007194612,0.107678816,-0.010828174,0.0146963205,-0.016562287,0.034641825,-0.1292214,-0.026406921,-0.04940787,0.01996988,4.0133546e-05,-0.06778088,-0.029212615,-0.056187216,0.012818046,-0.043899123,-0.030399626,-0.016670931,-0.036233097,-0.054939855,0.02276548,0.012132683,-0.010362379,-0.011374302,-0.060497895,0.06973514,0.018843897,-0.06717748,0.009019312,0.032463416,-0.023416076,-0.023178402,-0.11226497,0.064738706,0.05129175,-8.9341005e-34,0.07569902,-0.054055814,0.081437044,-0.03454375,-0.039958175,0.13156086,-0.0011563423,-0.03451685,-0.019780513,-0.024961801,-0.030544916,0.052121982,-0.0888178,-0.03258373,0.045411155,-0.04313451,-0.06587395,0.066883184,0.049030982,0.00060874864,-0.109208085,0.10007021,-0.020419233,-0.019891726,0.119500875,-0.042572323,0.017616855,0.08997592,-0.031108476,0.009383703,0.025534716,0.067940235,0.06386759,0.042954993,0.008615466,0.036141053,-0.01149327,-0.027530517,-0.014174543,0.025807414,-0.007072288,-0.02649624,0.01929013,0.044442885,0.09572233,0.09163444,-0.071949854,-0.004572802,-0.04068514,-0.027587928,0.033129208,0.025385413,0.019237993,-0.05335333,0.0776853,0.053239815,0.063792564,0.020144021,0.004336894,-0.09760993,-0.047179293,-0.036329437,0.00880849,0.048203006,0.052391328,0.032636177,0.030566933,0.03975533,0.045007873,0.049959045,0.057866942,0.014005713,-0.021593725,0.011159667,-0.021809928,-0.037820786,-0.040116716,0.01653347,0.09413533,0.028781677,-0.009912814,0.042119842,0.042486615,-0.032071687,-0.044440474,-0.02232596,0.061510205,0.08648098,-0.03727521,0.054249875,0.0186833,-0.0065834997,-0.08920194,-0.007701938,0.08919609,-2.7990314e-08,0.097288504,0.0622746,0.02054209,-0.11838508,0.0082843425,-0.12046111,0.032071583,0.043230947,0.007350187,0.042127278,-0.054139793,0.057737008,-0.009865325,0.029860854,0.04471585,-0.00972517,0.0010073889,-0.0078109405,-0.007809439,0.043352243,-0.06036433,0.029475663,-0.09116163,0.0056034257,-0.07839986,-0.12601997,0.041438602,0.0296681,-0.016083378,0.041057933,-0.038593836,0.034773827,0.014308711,-0.12665163,-0.019918516,0.0050420794,-0.06413249,-0.06666469,-0.014565338,0.019737823,-0.016231563,-0.06932879,0.037369132,-0.031539205,-0.08212877,-0.066365525,0.032735664,-0.011932345,0.03902601,-0.007413596,-0.008622134,0.012904558,-0.038146798,-0.068539485,-0.12736808,-0.01897389,0.0038602378,-0.016300073,-0.050111853,-0.09547627,-0.014472084,-0.025134047,0.072543316,-0.03992193 +3.2.1.140,"The enzyme from Streptomyces specifically hydrolyses the terminal lacto-N-biosyl residue (beta-D-Gal-(1->3)-D-GlcNAc) from the non-reducing end of oligosaccharides with the structure beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->R). Lacto-N-hexaose (beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc) is hydrolysed to form first lacto-N-tetraose plus lacto-N-biose, with the subsequent formation of lactose. Oligosaccharides in which the non-reducing terminal Gal or the penultimate GlcNAc are replaced by fucose or sialic acid are not substrates. Asialo GM1 tetraose (beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc) is hydrolysed very slowly, but lacto-N-neotetraose (beta-D-Gal-(1->4)-beta-D-GalNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc) is not a substrate.",384,0.99999994,0.030603435,-0.101889424,-0.06560722,0.0025395483,0.016358979,0.05097977,-0.050568007,0.032059956,0.121040575,0.013589382,0.0043136794,0.020128561,-0.014713701,0.020099066,-0.058077335,-0.09018037,-0.005831402,0.019620784,-0.0052982406,-0.018098414,0.11236079,-0.015875272,-0.010868338,0.03651033,0.053066216,-0.065912835,0.007835741,-0.010329096,-0.045241464,-0.069458626,0.019991105,-0.06347636,0.081414714,-0.0070372373,0.029723,0.073688224,0.011277818,0.0036380147,0.056594666,0.0020886913,-0.051783722,-0.038231045,0.049467497,0.01765946,-0.023047559,-0.012775076,-0.014824137,0.07759028,0.0039713252,-0.05178991,-0.039594553,-0.10956154,-0.09931312,0.06947868,0.10707055,0.05928394,0.021486076,-0.03402194,0.011202361,0.052358996,0.049963363,0.049772494,-0.01732158,-0.02148493,-0.08788463,-0.024649043,0.09326345,-0.08180246,-0.008182183,0.04956559,-0.084280044,-0.012433435,0.0058632004,-0.026951063,0.04447104,0.07248188,0.0007746942,-0.0012475328,-0.013292678,0.012062573,0.048988216,0.027078627,-0.0006990167,0.023061713,-0.029303325,-0.089708455,-0.03830925,-0.009652586,0.0965338,0.023070581,0.022420248,0.03274021,-0.01589775,-0.015988939,-0.036593504,-0.08375152,-0.0046022353,0.04167954,0.09499341,-0.05222509,-0.031317987,-0.01760628,0.05306375,-0.029315254,-0.030471856,0.06867485,-0.022611458,0.09566302,0.07548764,-0.0074278093,-0.02955009,0.0444634,-0.0011738768,0.004643937,-0.0792639,0.097923875,0.05984287,-0.116943166,-0.0075595025,0.020192364,-0.00058572466,-0.00047673218,0.108066745,0.022981174,-0.021557298,0.06574701,-0.024632594,-2.160979e-33,0.051846508,0.026423201,0.10658649,-0.048519272,0.0059359367,0.0007481891,-0.078614086,-0.050432835,0.014377436,0.027544621,-0.05090573,-0.006930687,-0.026812883,0.012021039,0.04818454,0.029281221,0.018605286,-0.013108424,-0.008356202,0.030275488,-0.05876545,0.04039228,-0.033711363,-0.06455402,0.08372281,0.036550846,-0.014344476,0.045212567,0.034961015,-0.006386851,0.031788904,-0.095492736,-0.106764175,0.06479893,0.057137836,-0.030708551,-0.08212,-0.02568095,0.060006328,-0.0048818295,-0.004428258,0.028869133,0.014687919,0.010585047,0.0028060714,-0.039658494,-0.0067759953,0.016984906,0.0060651246,0.08404409,0.061631065,-0.0027988774,0.0028818343,0.03312853,-0.057003498,0.03560351,-0.043918338,0.017463395,0.05924594,0.028601356,-0.0068617566,-0.0069942814,-0.011843761,-0.00960039,0.06796114,0.027625,-0.04694927,0.025299085,-0.0362604,-0.021524427,-0.07484871,-0.078576796,0.018493362,-0.0008453064,0.03498417,-0.028074399,-0.031321313,-0.011695581,0.0203033,-0.014803862,-0.031907804,0.024109326,-0.06645621,-0.03962206,-0.10927633,0.06608779,-0.012908714,-0.077274896,0.01319633,0.027048266,-0.031651314,-0.03939128,-0.08222853,0.07911471,0.03631269,1.6966137e-34,0.09901221,-0.10622001,0.03786756,-0.053995103,-0.041524373,-0.0043573775,0.03906286,-0.054261595,-0.0012182202,-0.104997896,0.04177032,-0.046294108,-0.067456216,-0.019411953,-0.048269622,-0.02010472,0.004835183,0.1042666,-0.02909665,0.06361887,0.04265022,0.0861528,-0.03772029,-0.032069728,0.032620147,0.006359124,0.013267584,0.06460474,0.061141368,0.09224908,0.08116496,0.03169762,-0.028913572,-0.060520597,-0.06877578,-0.012901387,-0.065837,-0.0365968,0.0937678,0.024252003,0.08564041,0.077547416,0.046086166,-0.04160918,0.0400461,0.121464826,-0.054308735,0.009421913,0.035985835,-0.054551616,-0.009063434,0.009516734,-0.022478517,0.049726177,0.027216367,0.06084515,0.07151268,0.04088109,0.018287264,-0.068794,-0.018693184,-0.0059807226,0.039447434,-0.106459305,0.06540141,0.0057648006,-0.0044234633,0.034040567,0.093814425,-0.018387515,-0.06509012,0.013800891,-0.04033447,0.0029330875,0.014012964,0.025731342,-0.17261894,-0.040618338,-0.04551582,-0.019729933,0.038795963,0.013963638,-0.0025845878,-0.022854334,0.02453747,-0.07337888,0.028002746,0.07947057,-7.434387e-05,0.05070227,-0.045965664,-0.013802321,0.0027118013,0.093681574,0.075274415,-4.6271552e-08,0.046530645,-0.041901253,-0.0096030105,-0.0400578,-0.023561869,-0.027003111,-0.051908184,-0.016126841,0.046956055,-0.036405798,-0.03979404,0.11090774,-0.027414534,-0.023616359,-0.052321713,0.01355221,-0.049726386,-0.066013284,0.026532933,0.054667287,-0.11102413,-0.01598457,-0.109499246,-0.013029609,0.041519318,-0.077168584,0.0769638,0.07086041,-0.0455627,-0.019967923,0.06775252,0.060372733,-0.017022448,-0.030401813,-0.0062179603,-0.011116828,-0.07754476,-0.001634481,0.01103975,0.034539003,0.045807317,-0.056662325,-0.055231545,-0.020745303,-0.026999364,0.019316059,-0.03308147,0.051449787,-0.058216948,0.05779395,0.031184325,-0.02081985,-0.0934593,-0.002925428,-0.004992439,0.0092511205,0.053290002,-0.016314285,-0.026653465,-0.025544843,0.0005277706,-0.05653302,0.13362889,-0.07799222 +3.2.1.142,"Plant enzymes with little or no action on glycogen. Action on amylopectin is incomplete, but action on alpha-limit dextrins is complete. Maltose is the smallest sugar it can release from an alpha-(1->6)-linkage.",384,0.99999994,-0.010947045,-0.08889589,-0.05350863,0.036572807,0.0016076675,0.07486376,0.002292419,-0.013364264,0.014169739,0.001363635,0.052516192,0.077203676,-0.17441525,-0.0027715648,-0.054591715,0.009392621,-0.0730182,0.010037823,-0.046810977,0.0006960067,0.07402774,-0.006717237,-0.002539737,0.029749963,0.06131245,-0.031092707,-0.07690886,-0.032763828,0.025877621,-0.075266026,-0.04584718,-0.023062987,0.08041637,0.06405625,0.004654812,0.1259947,0.003685258,-0.09524368,0.010305485,-0.057105858,0.048227385,-0.014338718,-0.022811603,0.041408353,-0.10843531,-0.046701957,-0.033863563,-0.08540171,-0.03895116,-0.007997439,-0.029820232,-0.082649365,-0.014893039,-0.0061254636,0.057854205,0.0027851916,-0.035368323,0.025331024,-0.00050713186,0.01812829,-0.0009791987,0.05435747,-0.025007438,0.007780213,-0.020003742,-0.036945336,-0.0074547557,-0.05395564,-0.032629594,-0.020582272,-0.00028031104,-0.052039437,-0.04075342,0.04733028,0.004955902,-0.0027631482,-0.03604946,0.019200329,0.009426395,0.01860654,-0.010947805,-0.02731587,0.04128901,0.0844024,-0.09220883,-0.05810285,0.028220069,0.041325103,0.033307116,0.026039278,0.067012794,-0.0080887005,0.006870935,-0.033416282,0.076220445,0.03392571,0.03878413,-0.17794012,-0.01826402,-0.033510234,-0.006519607,0.07531743,0.048495743,-0.043190207,-0.0374717,0.11411414,-0.044541877,-0.0345164,0.03368908,0.013536729,-0.009595836,-0.0023115338,0.05371305,0.037669342,-0.064155445,0.018131183,-0.010794886,-0.06665186,0.009036342,-0.023667851,0.0008873052,0.0112729985,0.092137076,0.04372516,-0.042908847,0.112177715,-0.08097084,-5.446554e-34,0.12532873,-0.036801495,-0.029197993,-0.05792043,0.0036905734,-0.0029321685,-0.009140549,0.0068957973,0.014333795,0.020668289,-0.10605955,-0.07553369,0.012808857,0.053897604,0.046320185,0.019478144,0.022939483,-0.051746726,0.061386745,0.067032434,-0.017701205,0.01455876,-0.05074754,-0.021325905,0.024442106,0.02932942,-0.03054434,0.022731371,0.009067178,-0.02974881,0.046445716,-0.04300149,-0.033717826,0.09580894,0.06768729,0.05072211,-0.024174396,-0.010274973,0.050390888,0.032620855,0.026068306,0.046694353,0.053423874,-0.066078074,0.07102954,0.03787656,0.0026549706,0.028221438,-0.024145208,0.11682547,0.044025123,-0.012817076,-0.016387694,-0.0040812423,0.000733604,0.07015884,-0.028384276,0.041003283,-0.02849844,0.06959557,-0.039066594,0.034608066,0.042413045,-0.044949118,0.033467975,0.06753085,-0.085461125,-0.048212655,-0.07383963,0.025796102,-0.061345432,-0.08521151,0.06526465,-0.029376544,0.03474934,-0.0263263,0.024602406,-0.036123823,-0.014018939,-0.036039203,-0.0011917566,-0.036724433,0.04011019,-0.0064610727,-0.08710817,-0.0060429657,-0.049728643,-0.0021031727,-0.0812466,0.01324851,-0.004810291,0.017654363,-0.008221852,0.011430509,-0.0103953155,-1.9010346e-33,0.11238748,-0.12680517,0.0844696,-0.024806831,-0.071938954,0.07055472,0.015512608,-0.06018289,0.011697968,0.013425429,0.03252409,0.05983582,0.018349025,-0.055949844,-0.030676069,0.01455012,-0.03176203,0.08440869,-0.007006554,0.034016456,-0.044662695,0.1175264,-0.0121075455,0.038185142,0.0775542,-0.0349279,0.040590864,0.08011644,-0.033251323,-0.04525388,0.045012392,-0.0326567,-0.018341687,-0.105866,-0.038237028,0.015466998,-0.045090064,-0.047115028,-0.017363606,0.015403466,0.052830517,0.045396544,0.031239912,0.07790445,0.062770315,-0.009555336,-0.080973625,-0.010006012,-0.038975377,0.036198247,-0.053337473,-0.0074545704,0.0042977575,0.07268215,0.03850134,0.037848108,0.053037133,0.013372303,-0.08044188,-0.020269364,-0.035934824,-0.008902009,0.027524248,-0.02382689,0.04271484,0.031791914,-0.0072211707,0.04348591,0.07034132,0.02497062,0.058240406,-0.024779465,0.047910735,0.040401682,0.0010545761,-0.0033977188,-0.06947346,-0.07105167,0.013733507,-0.08827362,0.04810858,0.10677363,-0.045810007,-0.073973395,0.02322176,-0.040397435,0.00095820415,0.096914195,0.020639164,0.06435845,-0.035369,-0.013164689,0.038900714,0.008042179,0.03595178,-3.0982697e-08,0.036075123,0.010094682,0.028663533,-0.041470174,0.01568955,0.0022565483,-0.018389463,0.035173286,-0.026797693,0.019938929,-0.037642352,0.122488044,-0.073084705,0.023541724,0.008044531,-0.04315799,-0.0051852204,0.03893691,-0.067741975,0.028772812,-0.1302776,0.019035881,-0.14047101,0.066134796,-0.011208078,-0.10624397,0.050756197,0.091225944,-0.027598573,0.022147005,0.08078417,0.07695894,0.014123317,-0.07206598,-0.0643977,-0.00415016,0.056738865,-0.04603543,0.005537704,-0.046516765,-0.0139054265,-0.05491463,0.0056123105,-0.04677115,-0.09309229,-0.0092721535,0.012133592,-0.07982233,0.044502307,0.09248083,0.075098306,0.029568829,-0.056711257,-0.05171033,-0.040449906,-0.009590863,0.0019104577,-0.015910719,-0.008683867,-0.041286953,-0.008319333,-0.03640486,0.12466295,-0.02960061 +3.2.1.143,Specific to (1''-2') linkage of ribose-ribose bond of poly(ADP-D-ribose).,384,0.99999994,0.03509855,-0.0626201,0.007348885,0.012562429,0.005239545,0.024119742,0.039745517,0.003367479,0.01359375,0.0010467257,0.025512114,0.05359623,-0.060923737,0.07931737,-0.07844139,0.04016886,-0.06317278,0.038493987,0.009018906,0.14627618,0.07594617,0.0008122367,0.029690294,-0.015670083,0.07646518,-0.046092074,0.0649377,0.00045058396,-0.015305158,-0.041890565,0.007833473,-0.020958668,-0.01234725,-0.032287568,0.070533104,0.036401827,0.057714455,-0.034072764,-0.012644656,0.038622577,0.078898974,0.05366094,0.05644016,-0.016668512,0.01570675,0.017551605,-0.1373582,0.083769046,-0.030773276,0.009098245,-0.007743648,0.01546947,-0.020480907,-0.08843147,-0.010860493,0.12244766,0.0013791928,-0.036357373,-0.020075783,0.011759202,0.03255416,0.024852948,-0.03537778,0.004133201,0.030169735,0.006011304,0.08452249,0.007829712,-0.019264689,0.04097316,-0.077289775,0.023133725,-0.08003193,-0.013224947,0.026305089,-0.012587387,-0.015771633,-0.09600104,0.021799317,-0.08909196,-0.016534738,0.0111911995,0.020300938,0.04723931,0.014128722,0.08508062,0.0053341878,0.007666157,0.0029436962,0.0012675725,-0.0004625774,0.017748456,0.017652847,-0.03347459,0.0045179217,0.0014798718,0.03255115,0.060021907,0.0061845835,-0.054517828,-0.02315315,0.040252738,-0.040180124,-0.07890134,-0.018600013,0.025740081,-0.062382836,0.049086947,0.029963912,-0.0001779898,-0.013589048,-0.0014465323,0.046815388,-0.02449186,-0.031916007,0.043792006,-0.044728093,-0.068134025,0.09986844,-0.081585355,0.023267435,-0.04376101,-0.017300647,0.06631573,-0.040823385,-0.03971331,-0.043818988,-1.2674139e-33,0.094478555,0.007900982,0.0853777,-0.0006862958,-0.009406923,7.702047e-05,-0.0965474,-0.08063498,-0.10261063,0.04354036,-0.19542363,-0.08460269,0.05388708,0.0043843514,0.014031682,0.0040867236,0.00064945285,0.009200221,0.022178883,0.011193282,-0.03534598,0.16240095,-0.0260388,0.05890077,0.037878107,-0.04688991,0.0056925113,-0.017096983,0.021816984,-0.03009188,0.0049564024,-0.0075596482,-0.0465785,0.049295984,-0.0052464125,0.02258783,-0.078870416,-0.04447755,0.008484926,0.058514748,0.103212394,0.020609058,0.104998745,-0.0012510612,0.011343632,0.01170953,0.037503555,0.012174578,-0.045866493,0.063625984,0.03460848,0.07809537,0.007814126,-0.0007609118,-0.051788572,-0.02212012,-0.08456516,0.012476967,0.020639366,0.0630249,-0.008874156,-0.023503356,-0.037145108,-0.0043896683,-0.046376128,0.055646338,0.0136388885,-0.061752632,0.024359256,-0.028978804,-0.049000658,-0.06706475,0.06045219,-0.028691428,0.008511609,0.026513554,-0.09548321,-0.04761794,0.035752866,0.028863817,-0.099947356,-0.048574794,-0.04136645,-0.031058606,-0.053822823,-0.028541524,0.049494237,-0.069028765,0.0027765608,0.059524197,0.018818209,-0.057077337,-0.053423025,0.04729438,0.07948111,-1.4302277e-33,0.0015971883,-0.07393444,0.06392627,-0.026286757,-0.10901907,-0.009423024,0.047383733,-0.053066585,0.026660375,-0.06492071,0.14878859,0.02883857,-0.027770575,-0.013435229,-0.077860914,0.08533752,-0.04064917,0.049959958,-0.027007677,0.006842512,0.032546047,0.025834814,-0.002201689,0.04812364,0.069630764,0.0044599646,0.07013183,-0.061071754,0.029372133,0.006618724,0.043939143,0.044314485,-0.03949722,0.037195496,-0.06363958,0.032659598,-0.058989063,-0.028416935,0.03780962,0.03052663,-0.07854593,0.030901782,0.042168062,0.016213179,0.051513426,0.04763568,-0.03406653,-0.08592946,-0.05266827,-0.01958703,-0.04854337,0.01854087,0.08626985,0.013193737,-0.010853655,0.050702956,0.004481061,0.055181164,-0.026493859,0.0042580646,0.021644624,0.038212158,0.060305193,-0.009262284,0.028045416,0.03774359,0.048224777,-0.035375196,-0.020351041,-0.08449983,0.03379467,0.036382206,0.010170322,0.069477275,-0.02466713,-0.14955723,-0.10256726,-0.03293322,-0.02584806,0.014099529,-0.025049774,0.016841276,-0.01227924,0.052336644,-0.0627655,-0.08555235,0.04730012,0.07686015,-0.019126115,0.009087301,-0.027997123,0.0369958,-0.020322371,0.033199433,0.05355211,-2.4426924e-08,0.011161999,0.004799818,-0.037857927,-0.15074468,-0.017598022,0.028146084,0.002906584,0.043933585,-0.02390352,-0.032883093,0.00204388,0.105750285,-0.057520594,0.0040930077,0.020131495,-0.04392675,-0.055550247,-0.10171655,-0.032944944,-0.044184104,-0.047621038,0.037736773,-0.07819209,0.01394381,-0.11598355,-0.03180305,0.0371264,0.010352341,0.09877303,-0.0048063854,0.045242075,0.039622832,0.011469149,-0.06335928,-0.012557845,0.1304755,0.0129349725,-0.029453984,0.032957282,0.09297703,0.022589538,-0.09576585,0.029616095,0.0036887103,0.06642047,-0.014207288,-0.02677341,-0.008748427,-0.045048043,0.016956532,0.05508348,0.033023693,-0.080857255,-0.0656728,-0.075269006,0.0052061323,-0.09055942,-0.01786782,0.043057386,0.011282288,-0.011841192,-0.014395967,0.06659802,-0.03807762 +3.2.1.144,"Releases Kdo (alpha- and beta-linked 3-deoxy-D-manno-octulosonic acid) from different lipopolysaccharides, including Re-LPS from Escherichia coli and Salmonella, Rd-LPS from S. minnesota, and de-O-acyl-re-LPS. 4-Methylumbelliferyl-alpha-Kdo (alpha-Kdo-OMec) is also a substrate.",384,1.0,-0.008991633,-0.08831499,-0.009869823,-0.047675394,0.014465008,0.08168853,-0.012280791,-0.02392553,-0.00202832,0.0595056,0.057148043,-0.05175626,-0.09201848,-0.015818007,-0.0030488486,0.013539479,-0.026606934,0.05348342,-0.0020027468,0.08337911,0.041890763,-0.044790883,-0.028725319,0.004475247,0.024841536,0.10538649,0.06803972,-0.021562079,-0.04087084,-0.062193036,-0.049730707,-0.053200703,0.07869193,-0.09141639,0.08506163,0.038739216,-0.004626595,-0.023324534,0.08580602,0.050927732,-0.011055017,-0.07942786,0.034239043,0.0058895424,-0.018801793,0.003114069,-0.06289172,0.022742178,0.07541544,-0.053852696,0.006110257,-0.070378244,-0.046288833,0.040589247,0.014448957,0.018391818,-0.05754448,0.036202114,-0.0131096,0.06953486,-0.023619592,-0.018892843,0.044313844,0.0658229,-0.03969297,-0.016287051,-0.0121802995,0.0049739005,0.053171232,-0.027581478,-0.020669688,-0.02082922,0.013521927,0.0014663854,0.042575266,0.07045502,0.07587168,-0.07756419,0.08702015,-0.07048616,0.07837973,0.004553325,-0.010851366,0.06423628,-0.013557024,-0.03279412,-0.021439675,-0.07419494,0.04032355,0.03961439,0.011908763,-0.013317723,0.032518853,-0.062904,-0.06576321,-0.0011134304,0.015752675,0.03232643,0.04517063,-0.004266584,-0.045487784,0.07013897,-0.04182103,-0.09759989,-0.054379612,-0.0072491616,-0.014278964,-0.02486712,-0.0094984025,0.0069275973,-0.008992923,-0.016112907,0.025612902,-0.07446857,-0.033620257,-0.00082931755,0.05058281,-0.076210745,-0.034004726,-0.08021992,-0.037624963,-0.09571524,0.019074745,0.03473773,-0.06992146,0.05457991,0.008562308,-2.0897426e-33,0.00523549,0.041311763,0.006745931,-0.057759076,0.055356856,-0.113903716,-0.0928152,-0.07115569,-0.08535872,-0.04855326,-0.045866903,-0.03620381,-0.007794332,0.06918874,0.019834107,0.072645485,-0.04346118,0.07876445,0.052960828,0.04407475,0.0326576,0.038073443,0.02420035,0.01503974,0.03959768,0.040151127,-0.04063036,-0.049106587,-0.011059031,-0.0026546677,-0.0061337096,0.033030767,-0.05452238,0.028982278,-0.033600785,0.02331412,-0.124542445,-0.04128809,-0.020847457,0.0685603,-0.008156002,0.022933854,-0.0740858,-0.011880301,0.035264824,-0.03463111,-0.075083494,-0.025360586,0.046657454,-0.05486865,0.047871403,-0.002604025,0.014335088,0.07618881,0.005040771,-0.029967817,-0.010715545,-0.029664526,0.052345913,-0.003665433,0.0028656975,0.10264093,-0.013084195,0.018454988,0.045466393,-0.014860873,-0.05821155,-0.01394141,-0.0069320607,-0.009936772,0.015733743,-0.012659316,0.0032803111,-0.030951729,0.003795528,-0.023316262,-0.082186334,0.011567499,0.06683625,0.025466522,0.0710498,-0.0066936184,0.017609362,-0.059896175,-0.055161107,0.033606138,-0.02629184,0.0054353364,0.014506241,0.013722468,-0.036623765,-0.06541226,-0.060945705,0.027495334,-0.030245638,-1.7359089e-33,0.06921822,-0.052492205,0.013611221,-0.10738625,-0.045370974,0.09930688,0.04566074,0.057243668,0.08007366,0.0014303724,0.04187083,-0.029552296,0.035846718,0.02220569,0.03956142,-0.00933709,-0.038017023,0.07543564,-0.084086634,-0.103865005,0.036764193,0.014472738,0.036931653,0.14181948,0.08821996,-0.023666639,-0.010425983,0.12233137,0.0010308424,0.040754315,-0.009517568,-0.02157755,-0.015189809,-0.0023285793,0.034576215,0.07491757,-0.06886989,0.067915305,0.0048810947,0.049348947,-0.017089358,0.054091502,0.0140881175,-0.023532864,-0.041861266,0.05398533,-0.033020843,0.006457782,0.07527222,-0.072191186,0.009710008,-0.032088198,-0.05364504,-0.0011391944,-0.007752961,0.09818872,-0.016907176,0.052881025,-0.047348537,-0.09800602,-0.11277246,-0.0893347,0.042562727,-0.023993358,0.04861779,0.114651576,0.026927052,-0.02573695,-0.037092213,-0.08720613,-0.030304588,0.042767603,0.016971773,0.038778245,0.016445141,-0.050207805,-0.12938848,-0.047276367,-0.017197,0.018143607,0.040793996,-0.058518637,-0.006638401,0.06599127,0.04697844,-0.055082,0.019090964,0.020547584,0.025418496,0.051202204,-0.011359972,0.01768086,-0.08395924,0.07937025,0.099075235,-4.0920806e-08,0.11052992,-0.06402428,0.039369952,-0.059881438,-0.011768719,0.030899659,-0.020354811,0.004546619,0.040679067,-0.101765946,0.037604704,0.14916354,0.040737923,0.06188093,0.0036739125,-0.03864016,-0.06348065,0.010197557,-0.014928519,-0.05902382,-0.07620107,-0.037114497,0.028535603,0.0068732253,-0.025877627,-0.033623554,0.074334055,-0.0030894456,-0.047762647,-0.042713903,-0.015913263,-0.0067970986,-0.04360487,0.028001765,0.03139023,0.019648036,-0.042726643,-0.050657697,-0.04512015,0.046209693,-0.018542064,-0.039684676,-0.042407498,0.021232983,-0.024103474,0.025257872,-0.05408659,0.09334123,-0.02617221,0.01138084,-0.0070131766,0.018744394,-0.05061807,-0.039223973,-0.07280851,-0.014320845,-0.07709348,-0.00034645858,0.013900833,-0.018862914,-0.014851838,0.020927064,0.2280608,-0.0069847074 +3.2.1.145,"This enzyme removes not only free galactose, but also 6-glycosylated residues, e.g., (1->6)-beta-D-galactobiose, and galactose bearing oligosaccharide chains on O-6. Hence, it releases branches from [arabino-galacto-(1->6)]-(1->3)-beta-D-galactans.",384,1.0,0.008488251,-0.039384704,-0.031281427,0.052850526,0.06346962,0.005704825,0.0010605075,-0.042778328,0.04399781,0.008421483,0.02828274,0.08443827,-0.07511386,-0.053255405,-0.04863649,0.024678435,-0.01463979,0.041551925,-0.021091707,0.032407183,0.12305022,-0.03172096,0.026375113,0.04015844,0.11068945,-0.08748362,0.0381366,-0.045041263,0.0056908433,-0.100522675,0.025347551,0.024336917,0.079786204,-0.00028939018,-0.021140032,0.05909555,0.034821387,-0.04092591,0.02444176,-0.0077931657,0.061535843,-0.025766203,0.05317473,-0.051140692,-0.033818774,-0.0074476604,-0.065914705,0.06570008,0.06792168,-0.01014965,0.003041583,-0.105688706,-0.08806829,0.018455936,0.036546566,0.063946724,-0.033251867,-0.10033355,0.005770909,0.043740332,0.06690432,0.032292407,0.0026153827,0.048120778,-0.046346914,-0.088308536,0.068848744,-0.02524024,0.0049887407,-0.02478114,-0.06464231,-0.03274271,-0.016655397,-0.04865919,0.04293122,0.029716183,-0.034442443,-0.052825686,0.041083716,-0.009863313,0.014669479,-0.029489785,0.027412988,0.03544505,-0.074195825,-0.048999798,0.05116653,0.037696376,0.010913017,0.028984103,0.03365333,-0.0033104075,0.012055147,-0.10046519,-0.05903287,-0.08034926,0.019388178,-0.0033834425,0.03490836,-0.0012694767,0.010577469,-0.0061295102,0.07123461,-0.05378975,-0.069301255,0.08354213,-0.03700745,0.08002979,0.060902793,0.013879168,-0.032812092,0.0070910496,0.039835025,0.018584581,-0.09578609,0.0919753,-0.024878133,-0.0704151,-0.04574604,0.04010902,0.015779242,-0.027714828,0.1171979,0.040682852,-0.05652763,0.08790264,-0.06190223,-4.1355347e-34,0.04545121,0.020553468,0.044033762,-0.08997683,0.024413943,0.024093615,-0.067886345,-0.06688515,-0.03830456,0.018199462,-0.12793857,-0.034099434,0.037215047,0.064867735,0.0689467,0.022264428,0.043152194,-0.055743713,0.031397786,0.024126535,-0.018309627,0.018863909,-0.06908251,-0.043089185,0.07977883,0.03125634,0.019307492,0.05135688,0.029203098,0.014847717,0.041523397,-0.014606912,-0.08161743,0.029849404,0.041067,0.023629379,-0.077906124,-0.05870944,0.024499493,-0.05113023,0.04642515,-0.012119567,-0.014260421,0.03912856,0.03148028,-0.028052684,-0.01024247,0.026616052,0.062547155,0.085853875,0.04046417,-0.035212614,0.03619363,0.01782519,-0.037252318,0.05929175,-0.060409024,0.03539773,0.013129581,0.073482506,0.0013990392,0.016349686,-0.037710078,0.048121385,0.01396338,0.064540945,-0.024217373,0.01058419,-0.07994975,0.0029762445,-0.10184278,-0.046375215,0.023603505,0.038868815,-0.039958104,0.008340208,-0.019717382,-0.009373859,0.021297386,-0.021840477,0.017700713,0.055958357,0.009724395,-0.03535575,0.00015626801,0.06891595,-0.04792169,-0.03526375,-0.037311893,0.045719057,0.047534235,-0.011887423,-0.06440913,0.06620525,0.009552062,-2.0841076e-33,0.096085,-0.07985031,0.06420539,-0.06724195,-0.03174759,0.05591076,0.08088624,-0.0027874485,0.017611645,-0.10165739,0.030766258,0.0109836,-0.019295383,-0.098282956,0.06407569,-0.04709426,0.015377718,0.055339925,-0.100339964,0.010747261,0.006847202,0.029328682,0.0054652626,-0.05334487,-0.025113598,-0.047091484,0.031410724,0.048197288,0.0045197937,0.056245796,0.003593646,-0.011826012,-0.039584104,-0.07010128,-0.040473923,-0.019686064,-0.08796249,-0.0046383636,0.031803604,0.04807006,-0.0459746,0.05956987,0.016251747,0.019941073,0.037483826,0.07874735,-0.057560597,0.04260285,0.03526917,-0.048437413,-0.019150713,-0.044015687,0.002612165,0.051030166,0.02383804,0.011572558,0.05660393,0.0038529157,-0.037223995,-0.033494893,-0.030950816,0.0026557231,0.06234776,-0.08200147,0.053223677,0.015284445,0.045162797,0.013486892,-0.007534101,-0.0136180315,0.020944552,0.016338,-0.07609545,0.028117029,0.024103155,0.05675941,-0.17371346,-0.06766425,-0.042007,-0.021006336,0.041223943,0.033603787,-0.046686087,-0.03301537,0.04592495,-0.11459771,0.0750501,0.08221432,0.029363256,0.045638125,-0.04336692,-0.015719635,0.009581601,0.008945436,0.03730558,-3.5749103e-08,0.032920595,-0.066427514,0.025448626,-0.09475255,3.3831864e-05,0.033151563,-0.024291135,0.033819187,-0.045876894,-0.04844694,-0.01462521,0.14567661,-0.049176805,0.038717892,-0.009835837,-0.05714059,0.024160605,0.058156416,-0.016806118,-0.029929666,-0.08832581,-0.034716498,-0.04944941,0.024056798,-0.009600804,-0.08548083,0.077960245,0.09639111,-0.05058654,-0.008836896,0.04377929,0.04345118,-0.034088578,-0.013040017,-0.08263431,0.07482387,-0.06973006,0.013632378,0.021940863,0.03441625,0.05281525,-0.022837475,0.017224737,-0.0361048,-0.07574635,-0.027327165,0.0023616212,0.02486396,-0.053562257,0.111952305,0.020730631,-0.024580177,-0.12516896,-0.049028795,-0.03360869,-0.06684431,0.02382263,-0.08266627,-0.010020601,-0.012107889,0.035595153,-0.069725476,0.15848501,-0.060242016 +3.2.1.146,"The enzyme from Helminthosporium sacchari detoxifies helminthosporoside, a bis(digalactosyl)terpene produced by this fungus, by releasing its four molecules of bound galactose.",384,1.0,0.060604043,0.017885525,-0.042148445,0.024414863,0.038105175,-0.026113758,0.00468395,-0.008921469,0.09614429,0.046862554,0.06722023,0.0032283254,-0.058441937,0.00072636286,-0.06562268,-0.019420383,-0.031571817,0.016541723,0.019375792,-0.028330239,0.08894034,0.015133798,0.008390245,-0.014348479,0.04440661,0.0013811827,0.017555151,-0.04119172,-0.02291104,-0.09684948,0.024979796,0.007881856,-0.0023696024,-0.07222298,-0.03616635,0.1022932,-0.07671027,0.015550505,0.05016318,-0.014609583,0.02044864,-0.029271975,-0.02571564,-0.04394891,-0.027475705,0.016617473,-0.0821094,0.014014903,0.048686303,-0.051893394,0.017516308,-0.040360477,-0.026218062,0.08443472,0.0012046838,0.033327077,-0.009738402,-0.024305677,-0.04649415,0.049262736,0.018040193,0.06545261,-0.0075404905,-0.022317503,-0.0093920715,-0.013655145,0.016864244,-0.03203565,0.00026902842,0.004590779,-0.094297744,-0.0369252,-0.016293835,-0.052665446,0.014104925,0.012104271,0.052963395,-0.065235324,0.077580795,0.00080386485,0.06428095,0.012654537,0.0035901347,0.027754515,-0.0064234263,-0.0036840758,0.05319039,-0.017449966,0.050834842,-0.043690447,0.04996545,0.032415323,0.0074463096,-0.051741034,0.022197282,0.02537598,-0.0029466506,0.046714846,0.011521312,-0.038443793,0.016496608,0.013629016,-0.082848676,-0.16763137,-0.05628946,0.0478666,-0.00066510634,0.057464603,0.08977311,0.019185621,0.028394213,0.013914535,0.07028117,0.0012997895,-0.072979115,0.10754376,-0.00095075497,-0.011008625,-0.016297827,-0.009708288,0.017492011,0.01920685,0.0044499855,-0.027526801,-0.020410001,0.06710098,0.024101166,2.4370599e-33,0.071512766,0.035986084,-0.06088084,0.02468956,0.03217004,-0.04469868,-0.00744405,0.014792936,-0.021126758,0.031243669,-0.107464865,-0.06548306,-0.09429694,0.038965125,-0.01473703,0.032597564,0.07145743,0.00086111686,0.0791362,-0.015966784,-0.0039793625,0.05224749,-0.056078155,-0.11496947,0.09572627,0.058246177,-0.06385271,0.04655248,0.029862387,-0.018914225,0.050754573,-0.010573609,-0.09627717,0.009191039,0.11790669,0.014262572,0.00888207,-0.0029755584,-0.09595498,-0.023890786,-0.001065928,0.06624604,0.013452291,-0.010273388,0.037362985,-0.089079484,-0.071353726,0.04806359,0.095449954,0.036851786,0.03735759,0.017724624,0.08278082,0.012650496,-0.03680295,-0.015477571,0.019952217,-0.0010321345,0.03191219,0.035432164,-0.028517783,0.06284529,-0.12878188,0.01563908,0.043743473,0.04141534,-0.06167558,0.057905506,-0.073775105,0.07641732,-0.08926773,0.019645076,-0.0625029,-0.01884717,-0.044846527,-0.0011043957,-0.059514962,-0.035534278,0.045204856,-0.029064879,0.037041664,-0.0057635293,0.0039944863,-0.03521226,-0.071512975,0.00989007,-0.019087201,0.016428256,0.021208944,-0.019868352,0.021537626,-0.0022986322,-0.034130346,-0.0029605296,-0.0059161843,-3.7342693e-33,0.11424312,-0.08067427,-0.0073615373,-0.073277295,-0.018929716,0.08347684,0.011358256,0.036272764,-0.043171514,-0.048002683,-0.0078015905,-0.050155666,0.04749519,-0.009172397,0.02903384,0.025817933,0.03597223,0.07022259,-0.083075196,-0.04034278,-0.016430426,0.16606049,0.031267665,0.04607843,0.03725726,-0.0728324,0.063899264,0.08375915,-0.053199492,0.020959469,0.014785067,-0.05484026,-0.006289375,-0.054020923,-0.027788276,0.020283656,-0.010680016,0.0036860125,0.011747586,0.06946217,-0.0145815285,-0.05461434,-0.0055928095,0.14545046,0.0952151,-0.003369479,-0.17452154,0.028610066,0.043036155,0.030963762,0.05631994,-0.07836866,0.036670476,-0.08435419,0.06507572,-0.025758892,-0.05064247,-0.033790134,0.029151134,-0.06703465,-0.03027005,-0.028775465,0.020143654,-0.015268611,0.07275414,0.044140924,-0.097019285,-0.012006084,0.02252371,-0.02604442,0.02490841,0.02016027,-0.08922131,-0.023439085,-0.032645307,0.015707776,-0.062593706,-0.037784785,0.058678932,0.061866138,0.06529295,0.009253065,0.068176106,-0.09116736,0.010354572,-0.051721156,0.03564318,0.04808409,-0.046808872,0.031179976,-0.07798521,0.020681141,-0.014298018,0.03725682,0.048576906,-2.9158631e-08,0.091270015,-0.011058552,-0.014026119,-0.01344313,-0.06847493,0.010851184,0.06366594,-0.0070321374,-0.0026036908,-0.019811433,-0.068878,0.12645844,-0.027585797,0.09357371,0.05164585,-0.0051634843,-0.025376061,0.023269448,-0.030611807,-0.0750427,0.009609744,-0.034029283,-0.029865837,0.040199246,0.041446038,-0.08296947,0.05954288,-0.007095267,-0.025659675,0.015575147,-0.025218816,0.0105359815,-0.032048177,0.022425778,-0.0110508455,0.09040603,-0.067922555,-0.043298945,0.007006381,0.043801792,-0.008859943,0.03948016,-0.07179636,-0.03877216,-0.079104096,-0.015547758,0.06519279,0.046633054,-0.031218914,0.020496126,0.02736744,-0.057617933,-0.037037425,-0.0020622786,-0.08061372,-0.08451202,0.043625567,0.030018441,-0.008629445,-0.08576167,0.01461294,-0.012046757,0.19569434,-0.041544273 +3.2.1.147,Has a wide specificity for thioglycosides.,384,1.0,-0.045662023,-0.079163454,-0.06893764,-0.008117705,-0.026705708,-0.059822362,-0.0029918149,0.16138788,0.038758676,-0.033913244,0.00082653033,0.04205166,-0.07900557,0.0010742209,0.0319194,-0.027486322,0.020953346,-0.005363293,0.02717018,-0.052705057,0.083376326,0.054719735,0.027134815,0.00143686,-0.067465425,-0.007467411,0.026674934,-0.011208917,-0.044524144,-0.061154954,-0.052259203,0.05329797,-0.00036998102,-0.04792729,0.000939183,0.05034131,-0.08707208,0.05719415,0.035385102,-0.07790664,0.04523714,-0.091340974,0.02321277,0.024882734,-0.06580869,-0.07868613,-0.039776064,0.08325127,0.011057301,0.13941377,-0.055940945,-0.07242707,-0.025760075,0.05280117,-0.037955403,0.0019876142,-0.083937965,0.012474626,-0.028254244,0.0045810845,0.0047757654,-0.0042617726,-0.01762442,0.05651687,-0.013889363,-0.018846486,-0.00018829296,-0.021138,-0.018389469,0.004462154,0.00097275636,-0.0046157953,-0.002218256,0.13004948,0.071493395,0.06236688,0.018314725,-0.048789985,0.0065563847,-0.040581275,0.054638576,0.07871725,0.051237527,0.081635624,0.059313744,0.007037144,0.021547543,0.0067627565,-0.07843366,-0.027636189,0.098448224,-0.033019602,0.015134063,-0.023106255,-0.030567138,0.005917625,0.009535598,-0.02193126,0.007726088,-0.034391697,0.023315031,-0.0052159065,0.03454767,-0.03401475,-0.018506072,0.045937866,0.0034614636,0.010921653,0.0058092647,-0.017688878,0.005105834,0.028226018,0.100352585,-0.0631462,-0.058766074,-0.022319747,0.03596526,-0.021716474,-0.0067838184,-0.03585941,-0.03512743,-0.039058365,0.02604693,0.006679646,-0.024228169,-0.0068083983,-0.044314705,-1.2752447e-33,0.07413931,0.033301186,0.0456175,-0.04033879,0.07345002,-0.018732697,-0.018451825,-0.063189544,-0.010602067,0.0856213,-0.084213614,-0.076051995,-0.01072135,0.070264876,-0.018302979,0.016194995,-0.06291895,0.052635383,0.05998659,-0.052822225,-0.02056881,0.04962874,-0.020704832,-0.0106593035,-0.05318987,0.085978284,0.021765174,0.11135973,-0.0032760021,0.0045326427,0.008106233,-0.020296456,-0.0013529075,-0.035866186,0.039280713,0.08074208,-0.044356745,-0.005511412,-0.0033541985,0.03081934,-0.010289023,0.03673016,-0.03414769,-0.043363057,0.06804814,-0.072758965,-0.09415297,0.053098626,-0.038499154,-0.011484311,0.0077726967,-0.044422124,0.0837745,0.004169183,0.026380533,0.0027676304,-0.0036958214,0.055795778,0.010742071,0.07717125,0.039792527,0.10712944,-0.04762613,0.022772701,-0.07693971,0.040007155,-0.11783935,-0.037479382,-0.086476296,0.034389693,0.03207213,-0.013515668,0.07447363,0.0015846236,0.0058585377,-0.022796331,0.011689994,0.003927067,0.0376558,0.010992663,0.014819155,-0.05719255,0.008116099,0.012174154,-0.100179866,0.01784859,-0.00724157,-0.09728077,0.019986209,0.012030403,-0.040203214,-0.016237801,-0.095948696,0.063481405,-0.038085405,-5.1320995e-34,-0.038697407,-0.059531644,0.06849255,0.023776732,0.019095404,0.00032439362,0.016955407,0.032525744,0.08081975,-0.023418475,0.12783884,0.0452619,-0.08427269,-0.10108426,-0.008786314,0.07626152,0.011283628,-0.00035950769,-0.04161816,-0.0015502953,-0.066072196,0.022983585,-0.059737336,0.07794797,0.050108317,0.032853406,-0.031776343,0.012370042,-0.049101695,0.06605651,0.0355901,-0.049787104,-0.11470549,-0.08667161,-0.04374003,-0.018019326,-0.068967104,-0.03201412,0.019176073,0.015889285,-0.018202025,-0.034652893,0.07304382,0.06258343,0.101112925,0.04151765,-0.05161349,-0.02977143,0.028132189,-0.042189904,-0.0011843729,-0.008215542,0.029042901,0.09236746,0.064081214,0.06427939,0.013952934,0.0021040142,-0.019338103,-0.039479587,-0.05928498,-0.039845765,-0.022709921,-0.009492999,0.078404345,-0.014422126,-0.07971241,-0.030318242,0.024520036,0.037907403,0.06114387,-0.023716465,-0.07684541,-0.013029224,-0.0061877836,0.034879275,-0.05971591,-0.05302108,-0.073005855,0.03840979,-0.011444595,-0.013451218,-0.036652286,-0.0715332,0.007888315,0.039309606,-0.024240352,-0.0031862815,-0.005969422,0.08275518,-0.07116016,-0.021338921,-0.060049612,-0.023181872,0.026065143,-1.9782055e-08,0.08089449,-0.054179486,-0.012107906,-0.059210487,-0.10029296,-0.0048375507,0.05067073,0.05684827,0.018994214,0.06019188,-0.03882969,0.18517025,-0.0029304035,0.020490237,0.06833854,0.009160207,0.0059385877,0.015947733,-0.035027295,-0.029390188,-0.05077068,-0.002103922,0.048663754,-0.013841809,0.005552185,-0.045940574,0.042309724,-0.06845207,-0.020047082,0.028641172,0.014156005,0.041559808,-0.013105052,0.0046645133,0.07500711,0.083545044,-0.0358636,0.01298468,-0.03286309,0.024031509,-0.02160107,-0.030967936,-0.07379799,0.060601648,0.005497151,-0.06658465,0.015417901,0.14519028,-0.07736249,-0.0030286792,-0.05604606,0.0328443,-0.05718184,-0.069201685,-0.0362962,-0.0030249476,-6.454833e-05,0.0008072931,0.014855082,-0.076192275,0.046614565,-0.0053746337,0.21538512,-0.01779683 +3.2.1.149,"The enzyme is responsible for the formation of the alcoholic aroma in oolong and black tea. In addition to beta-primeverosides [i.e. 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranosides], it also hydrolyses 6-O-(beta-D-apiofuranosyl)-beta-D-glucopyranosides and, less rapidly, beta-vicianosides and 6-O-(alpha-L-arabinofuranosyl)-beta-D-glucopyranosides, but not beta-glucosides. Geranyl-, linaloyl-, benzyl- and p-nitrophenol glycosides are all hydrolysed.",384,0.99999994,-0.015070247,-0.08304828,-0.07384392,0.035600077,0.053501647,0.06526485,-0.036418915,0.009728526,0.07285051,-0.05354626,-0.026214633,0.099543445,-0.08767922,0.00947959,-0.04190221,0.017316941,0.04975778,-0.010323183,-0.021255905,-0.009100271,0.007468842,0.003649157,0.067384645,-0.005877739,0.09004531,0.0067523867,0.039705932,-0.0041120984,-0.014431128,-0.066144034,0.037351992,-0.028405806,0.013275542,-0.018922273,-0.026033571,0.0077479654,-0.028557107,-0.037548766,0.08508126,-0.04948508,0.006600492,-0.027234053,-0.039830405,0.034012713,-0.07484588,-0.023248106,-0.023948183,0.032521546,0.046305794,0.03079379,-0.05866801,-0.10128571,-0.04601658,0.02684155,0.028033737,-0.09707032,-0.052559264,-0.028832793,-0.005057098,0.10169411,-0.02632891,0.04604883,-0.014765934,0.052153327,-0.0864671,0.037067585,-0.048018046,0.049680162,0.012279724,-0.0113602355,-0.0030574882,-0.06120961,0.0061335354,-0.031933982,-0.016792364,0.08160451,0.0031422637,0.017091347,-0.056871764,-0.01642568,0.04549477,0.03806139,-0.025099112,0.14040294,0.016538618,0.02515156,0.0019670383,0.028098272,0.0008924727,0.007395939,0.077169746,-0.045203388,-0.052359976,-0.028357074,0.03103027,-0.0033774055,0.0782193,-0.046805535,-0.012733597,-0.03596122,-0.083835036,-0.0016120528,0.023660025,-0.051277105,-0.09678152,0.07932895,-0.04652918,0.012812347,0.11113001,-0.03579297,-0.03738929,0.03605419,-0.0027774947,0.006714967,-0.12686117,-0.056152858,-0.011313812,-0.0089267865,-0.07386082,-0.022068664,-0.020410692,-0.044831384,0.08649902,-0.009744341,-0.050689038,0.04213539,0.008511456,8.14141e-34,0.009415752,0.02004393,0.010441051,-0.002743481,0.056476608,-0.0409081,-0.053686768,-0.04616242,-0.011343197,0.07340469,-0.060599994,-0.039962616,-0.09562114,0.05015632,0.051972993,0.06761299,0.034772187,0.033551846,0.08280597,0.0060137077,0.01957175,0.06485379,-0.05002386,-0.005644284,-0.099457696,0.037753534,-0.015744172,0.09129887,0.039195567,-0.01758812,0.03520635,-0.058441695,-0.03293899,0.05714125,-0.005311176,0.015978267,-0.08453196,-0.03247103,0.06634201,0.026432263,-0.021677703,0.04904214,-0.028498119,0.034837797,-0.035140965,0.021847075,-0.073271364,0.0053152097,0.042784188,0.060391955,-0.004250333,-0.039091825,0.072270416,0.10257672,-0.038806356,0.036363248,-0.059869148,0.008639464,0.06624768,0.03490301,-0.0006417097,0.02426342,0.024239875,-0.099153906,-0.021591257,-0.02322278,-0.095952965,-0.02004534,-0.056084793,0.016289108,0.041649662,0.0023278364,0.018166805,0.054582104,0.0665563,-0.05352969,0.06556353,-0.016131815,0.09954713,0.0032921925,0.0010737741,0.0040440005,5.5308257e-05,0.034651406,-0.06643437,0.06487257,-0.06772997,-0.013204151,0.0098553235,0.065944985,-0.03257431,-0.037993766,-0.08280753,0.04084134,-0.020216152,-1.679678e-33,0.090720065,-0.11920818,0.04373625,-0.04338734,-0.049376342,0.010433426,0.01952855,-0.04086611,-0.0041892007,0.04191245,0.024659839,0.045895588,-0.051234927,0.024258208,-0.060324367,-0.0009781236,0.0527327,0.11829146,-0.036715217,0.0095362095,0.0016555645,0.066420555,0.049473062,-0.051000368,0.03583285,0.017453115,0.07948261,0.038411863,0.02727389,0.073359385,0.0930212,0.08062618,-0.03379053,-0.056585148,0.013485569,0.013199754,-0.06664572,-0.028993126,0.0023126742,0.03831735,0.053117007,0.05760281,0.00074446324,-0.027893852,0.15438719,0.042034723,-0.1373456,0.01323214,0.011283625,-0.037283905,0.030463895,0.028202295,-0.042144053,0.08209489,0.060241982,0.004614917,0.034391295,-0.047614664,0.047669847,-0.06905407,-0.04949887,0.01353366,-0.014359051,-0.043454137,-0.021126484,0.07015796,-0.043865483,0.024756467,0.039672527,0.046415053,-0.0018274758,-0.1056079,-0.046138145,0.08023877,-0.015052859,0.0010100565,-0.10402643,-0.069523595,-0.004472312,-0.033264514,-0.04514109,0.08103094,-0.057845116,-0.04515051,-0.028202457,-0.036735684,0.04107809,0.10800385,0.0541814,0.04388704,0.023843003,0.01734382,-0.047194567,0.085379325,0.08336711,-4.6970403e-08,-0.03699569,-0.09179605,0.06836485,0.031801514,-0.047198385,-0.07068466,0.052814264,0.0026085798,0.029398652,-0.030806664,-0.057769038,0.082072616,-0.04505221,-0.014654257,-0.03079054,0.03374527,0.038583435,-0.020107066,-0.012145784,-0.046500098,-0.07895328,0.022307,0.025392385,0.019578073,-0.0071893926,-0.12468766,0.06009668,0.016338345,-0.0063368576,-0.015460542,-0.005974709,0.06955623,-0.035965826,-0.039260406,0.004667932,-0.003922365,-0.043855023,0.01445387,-0.012195034,-0.0130723175,-0.05029633,-0.09600289,-0.011583152,-0.016438993,-0.014873318,0.011752377,-0.0025375336,0.058011465,0.014415883,0.05643222,0.071944915,0.02050684,-0.014453368,-0.05355933,-0.0902499,-0.021041851,0.004747103,-0.034936264,0.009273402,-0.14201592,0.027924048,-0.03727021,0.13344249,-0.054336444 +3.2.1.150,The enzyme is found in the fungus Geotrichum sp. M128. The substrate is a hemicellulose found in plant cell walls.,384,1.0,-0.00043356777,-0.012405042,-0.08745931,-0.035437133,0.06306673,0.023190903,-0.03226218,0.03410581,0.049626973,-0.01634719,0.07413495,-0.04532684,-0.104714386,0.010832191,-0.0774923,0.011232999,-0.0091352835,-0.006797729,-0.0065322,-0.056110643,0.07625523,0.08628971,-0.0014954226,0.022426575,0.04828702,-0.046113368,0.029081322,-0.024832577,-0.024059754,-0.06917998,-0.030328384,-0.004832908,0.10383456,-0.01820674,0.050668504,0.11944155,-0.061770946,-0.01867409,0.06339113,0.0050971773,0.008381509,-0.0906423,0.007883307,-0.0311739,-0.09752071,0.0153858755,0.009347627,0.024785468,0.03984749,0.019834628,-0.042218294,-0.07154014,-0.005915043,0.020604976,0.033088427,-0.0030742385,0.041324373,0.008604883,0.01363108,0.049734395,0.04938259,0.039392736,-0.05755957,-0.016146421,-0.05571411,-0.059283394,0.056633275,-0.030379314,-0.007168396,-0.068716645,0.006445399,-0.052303974,-0.051868904,-0.006917244,-0.0125329485,0.022035167,-0.044443164,-0.08128734,0.085005105,0.028604278,0.05136469,0.0795107,0.07181613,0.07496577,-0.00032308084,0.008874832,0.0054918746,0.055736363,0.020211704,-0.07085815,0.071393356,0.03752203,-0.07284793,0.025520213,-0.042456795,0.08660701,0.010036679,0.057320595,0.051406506,-0.040483646,0.039406434,-0.038386516,0.022938376,-0.051478818,-0.08494829,0.041084863,-0.0075790114,0.08343315,0.11059573,-0.0356075,-0.050038278,0.011267639,0.037961468,0.0056803008,-0.009859761,0.03768251,0.058821656,-0.042306785,-0.05816989,-0.0018530516,0.018855853,0.00054011313,0.05402257,0.020641966,-0.014316091,0.04865739,-0.10365725,-1.6531647e-33,0.09410211,0.036745396,-0.009663002,-0.047113366,-0.029456632,-0.030603925,0.011031398,0.012628495,-0.04860409,-0.027934577,-0.10501221,-0.11030789,-0.054234806,0.07323342,-0.053073715,0.0012332775,0.025643853,-0.06997686,0.027068272,0.070505254,0.03510985,0.033113122,-0.08049167,0.030448958,0.011807652,0.072032705,0.0030540621,-0.050179113,0.071559906,-0.0010302243,0.059037626,-0.07235592,-0.072186716,0.041896246,0.05848029,0.019218123,-0.04386681,-0.004506031,-0.05735914,0.00568464,0.016315412,0.04958,0.072295286,-0.05354807,0.097146496,-0.053068537,-0.045387097,0.058346305,0.0931247,0.06898194,0.035379637,0.07522259,0.07151108,-0.019878263,-0.011920257,0.03987144,-0.0025613962,0.059174716,0.04147317,0.035046276,-0.0066141663,0.07516997,-0.01346532,0.06625077,0.047132555,0.016422268,-0.11121578,-0.02154822,-0.030966816,0.054972563,-0.03260699,-0.012416156,-0.023503492,0.043207984,0.008995535,-0.09633482,-0.079577275,-0.02508609,0.015976021,-0.062320616,0.019465521,-0.045022458,0.0062213964,-0.04520532,-0.12880889,-0.04452827,-0.017107988,0.015954051,-0.047759462,0.033437848,0.0054503083,-0.061688766,-0.099831775,0.027374458,-0.010635349,-7.390715e-35,0.09219354,-0.092523776,0.043318897,-0.029378038,-0.06117597,0.068553515,-0.033762433,0.018926965,-0.007589766,0.035671055,0.08309929,0.042047795,0.007818961,0.035819244,0.033444732,0.05714312,-0.0063313516,0.06172732,-0.042766664,-0.0153746,-0.047879167,0.08747654,-0.011730291,0.013422209,0.047275566,-0.036717076,0.05634869,0.042623077,0.026582507,0.020770108,-0.06754054,-0.0022536782,-0.022275295,-0.03941644,-0.026046181,0.02182889,-0.011896546,-0.103253186,-0.009356227,0.00097069883,0.012835203,-0.008915233,0.037430707,0.05119064,0.021039004,0.086112544,-0.075088196,0.057395175,-0.034071982,-0.024896126,0.008821483,0.013629604,0.011927276,-0.024477055,0.03844152,0.0071332436,0.002276281,0.03780019,-0.05230451,-0.058049105,-0.046433058,0.004399297,0.0029316915,0.03429346,0.0501018,0.13845864,-0.08050543,0.06486026,0.018048974,0.003129865,0.055713426,0.045204025,-0.018899368,0.016618654,-0.04387615,-0.01692523,-0.033031333,0.00449291,-0.021487221,-0.0048314347,0.08448155,-0.0016644355,0.04338393,-0.09076567,0.044079486,-0.09184948,0.044083193,0.108180165,-0.05610492,0.037689947,-0.038681805,-0.00802558,-0.09865745,0.027455505,0.06457919,-2.5179961e-08,0.00026932024,-0.032630067,0.030300066,-0.1798305,-0.03042013,0.0016517725,0.099243075,0.03692773,0.027358195,0.017039197,-0.040388882,0.09139778,-0.010643359,0.02403653,0.05049029,-0.041562337,0.0037804455,0.0022750467,-0.026951903,0.044644006,-0.021301985,0.011201447,-0.0832432,0.024071466,-0.019384498,-0.07358943,0.025133986,0.03607951,0.013863654,-0.029842366,0.008165154,0.08498246,-0.036788784,-0.043922864,-0.042916365,0.07389772,-0.075089924,-0.06404154,-0.051350977,-0.008716226,0.033492967,-0.10050283,-0.01812054,-0.07661055,-0.0142691815,-0.025228113,0.005938484,-0.0010624963,0.016311312,0.005205901,-0.02834169,-0.028479109,-0.034162447,-0.03461624,-0.054552816,-0.039149173,0.03158473,-0.06606883,-0.002874548,-0.11843821,-0.040944643,-0.02217337,0.15868615,-0.02035085 +3.2.1.151,"The enzyme from Aspergillus aculeatus is specific for xyloglucan and does not hydrolyse other cell-wall components. The reaction involves endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues.",384,0.99999994,0.013617665,-0.023118084,-0.08317416,0.011647072,0.021472413,-0.058760673,-0.059860826,-0.0034579607,0.013631633,-0.061110027,0.04136654,0.012439394,0.042592175,0.09320315,-0.12113664,-0.0051433095,-0.021677395,0.019475076,-0.076333255,-0.022043345,0.1001057,0.05335586,0.01849877,-0.0028096635,0.08187224,-0.055957064,-0.03869263,-0.087679505,-0.028677354,-0.11765815,-0.06928342,-0.039181497,-0.015412422,-0.020068645,0.0700458,0.07527522,-0.03250569,0.017693698,0.06178953,0.01861724,-0.012464545,-0.067211695,-0.014645893,-0.001521183,-0.0970317,-0.03402217,-0.060830094,-0.013555181,0.029362235,0.10453699,0.03601345,-0.02425711,-0.060930923,0.005607828,0.06923313,0.038637873,-0.029256273,-0.031902872,0.0031947964,0.03490603,0.02695511,0.0646509,-0.058709916,0.005736184,-0.066293925,-0.137741,0.010608266,-0.034686968,-0.045278553,0.00024984605,-0.024510229,-0.049410056,0.030514905,-0.004766258,0.10407522,-0.010357246,-0.00025549156,-0.02984862,0.06141238,-0.014893378,0.07280163,0.018098326,0.049528927,0.045162745,-0.027343407,-0.053425316,0.0133907255,0.042143304,0.01973031,0.008209485,0.0750307,-0.0064003197,-0.031011995,-0.033672497,0.055331778,-0.004925911,0.12666693,-0.017620534,0.030990815,-0.06867114,-0.0063058133,-0.04865965,0.08811803,-0.04960455,0.025045095,-0.023868492,-0.041131645,0.10863191,0.038249068,-0.035131186,-0.01967733,-0.07260886,0.038003698,-0.011708467,0.029912166,0.04499579,0.04353633,-0.057427824,-0.089212306,-0.077460095,0.025628919,0.0022101211,0.007900016,0.043733973,-0.006130918,0.040407896,-0.01529366,2.0296589e-33,0.030358829,0.047094334,-0.07855029,-0.030379847,0.0020908567,-0.03281723,-0.004806644,0.037182443,-0.04136634,0.054733112,-0.043477837,-0.030216858,-0.071850754,0.11476561,-0.048666444,0.024284344,0.031234948,-0.050954405,-0.03087644,0.037403226,0.045336585,0.06427862,-0.044587143,0.015069708,0.0506547,0.037874877,-0.018646572,-0.0015439478,-0.008537546,-0.020062393,0.0073200203,-0.060512107,-0.08330614,0.0728059,0.07486897,0.08992618,0.017290715,-0.02468995,0.035659846,0.0005243121,0.010490283,0.001348819,-0.02481801,-0.12966217,0.03980578,0.012170465,-0.085865065,0.035456426,-0.057960346,0.046953935,0.124155976,0.056973893,0.025884187,0.07210704,-0.012053753,0.03421725,-0.02355804,0.028784966,0.003907469,0.046714477,-0.0031376213,0.03851985,-0.02744484,0.018115368,0.0011881655,0.011608721,-0.02703902,-0.013193377,-0.05921561,-0.005678444,-0.08470053,-0.05545364,0.051648617,0.007700827,0.006628301,-0.045343153,-0.04763539,0.06642405,0.025610117,-0.014739579,0.01986935,0.052959733,0.018856004,-0.017701646,-0.1297576,0.031211738,0.038306594,-0.011066,-0.020089252,0.08413603,-0.05319623,-0.040399935,-0.032527555,0.065742694,0.03636109,-4.671518e-33,0.14385428,-0.13954903,0.108712025,-0.03959867,-0.06714014,0.07605252,0.033884082,-0.042279568,0.021366889,0.00078461267,0.034574244,0.09221527,-0.040278386,0.02541859,0.034818295,0.03067496,-0.020600138,0.0857974,-0.050812233,0.020707112,-0.0462735,0.065975174,-0.010220853,-0.0009916872,0.06290809,-0.031170378,0.0022812744,0.0041738884,0.031549856,0.0047558513,-0.028826123,-0.014121373,0.031489197,-0.051574007,-0.06813067,0.033435024,-0.040626906,0.025906907,-0.027544463,0.022258816,0.046345886,0.021029776,-0.026560873,0.05813037,0.0873318,0.06671771,-0.027412219,-0.036663517,0.020764895,-0.049871255,0.034049824,0.023197357,-0.0045121177,0.017081581,-0.004390974,0.08182104,0.05525307,-0.020396696,0.033711836,-0.06282671,-0.08864578,-0.03816514,0.021578856,-0.051098768,0.08549288,-0.00794096,-0.011399065,-0.029111026,0.033817,-0.025381172,0.07584663,-0.02942242,-0.028137447,0.029041583,0.036726788,0.007223336,-0.07023972,-0.06459984,-0.015748747,-0.016132073,-0.00027270245,0.04204869,0.062159017,-0.063740805,0.040803816,-0.053917382,0.03105709,0.1298886,-0.043588106,-0.015612404,0.023586879,-0.029866267,-0.030407244,0.008675436,0.12536722,-3.5941962e-08,-0.0069375127,0.044728335,0.02923794,-0.09101462,-0.025048226,0.03471937,0.054890987,0.023606095,0.048589658,0.014951851,-0.07254891,0.06462575,-0.029640362,-0.0033111023,-0.048519485,0.023241868,-0.045904916,-0.012642945,0.01619938,0.00018992147,-0.09721544,-0.021914216,-0.09799909,0.04773581,-0.064112835,-0.074938215,0.058955126,0.053821087,-0.00012960014,-0.019605383,-0.0434746,0.07495056,-0.087425224,-0.08190335,0.0075856163,0.005690748,0.02679123,-0.083238706,0.048006818,0.0013743255,0.001771761,-0.03291667,-0.019112082,-0.02191454,-0.05128222,-0.027233101,-0.019697176,-0.08697229,-0.0079212645,0.05655276,0.05570039,0.0138604995,-0.045038484,-0.12452949,-0.05200607,0.008477089,0.013273083,-0.027656205,-0.0074498137,-0.04795738,-0.022387555,-0.021889376,0.16557363,-0.06755015 +3.2.1.152,"The substrate group is a substituent on N-4 of an asparagine residue in the glycoprotein. The mannose residue at the non-reducing end of the sequence may carry further alpha-D-mannosyl groups on O-3 or O-6, but such a substituent on O-3 of the beta-D-mannosyl group prevents the action of the enzyme. The enzyme was obtained from the lily, Lilium longiflorum.",384,0.99999994,-0.0080771465,-0.0329886,-0.026184589,-0.035873197,0.075646296,0.056361366,-0.04924446,6.78022e-05,-0.043493103,-0.00070872915,0.13796087,0.0073042093,-0.09888355,-0.020720132,-0.08658531,0.0115223415,-0.028486673,0.023087464,-0.08341627,-0.046882723,0.05465957,0.019210903,0.032631796,0.0057520517,0.0855617,-0.08561542,-0.028159427,-0.09180098,0.083065726,-0.13763471,-0.007726524,-0.020815426,0.09380477,0.0060201325,0.060504217,0.051973175,0.05600053,-0.08169885,0.009641535,-0.007322283,0.037431203,-0.03954537,-0.045836315,-0.022402054,-0.13036072,0.04908186,-0.011550096,0.024110554,0.042447314,0.059902884,-0.026648557,-0.06212571,-0.02427578,0.037603583,-0.09125402,0.02301132,-0.0014796815,0.030756136,-0.012759193,0.06603277,0.0028863822,0.026367806,0.029043578,0.020625105,0.026047746,-0.027832102,-0.021603033,-0.07588235,-0.009443974,-0.002709123,0.024946205,-0.096903555,0.0045635034,-0.024082523,0.057866186,0.03676651,-0.033629578,-0.046662886,0.046450533,-0.06654029,0.06325395,0.047669414,0.10222019,0.08045097,-0.07624532,-0.0016941016,-0.01898173,-0.0030316336,0.10382935,-0.021158999,0.017167656,0.023346122,-0.034709863,0.0018780631,0.0018590436,0.036776498,0.0768651,-0.016492374,0.0228096,0.0024239118,0.033434827,0.06123249,-0.03313168,-0.049214173,-0.0667368,0.009842544,-0.054498214,-0.03222912,-0.002408564,-0.028550882,0.057455253,0.02441968,0.03113346,-0.032436404,-0.12233086,-0.048283566,0.02379737,-0.047180083,-0.03618737,-0.041228157,0.041834973,0.015002198,0.01665705,0.07138414,-0.03729142,0.1069378,-0.09223841,1.1916428e-33,0.06456157,-0.0076853815,0.018289514,-0.041489154,0.028422398,-0.02341859,-0.032983534,-0.031453103,-0.06575265,-0.043117896,-0.10107034,-0.12378022,-0.06795314,0.027094018,0.022228103,0.03392667,0.0050052875,0.027640155,-0.010082436,0.016954998,-0.02844242,-0.00037542637,-0.06945893,0.02206599,0.05949751,0.07302252,-0.04032564,0.00805343,0.03641929,-0.0022414618,0.06599755,-0.047464892,-0.08316114,-0.003904737,0.013284278,0.0060816756,-0.062336925,-0.032629594,0.033650205,0.0428866,-0.026835516,0.08007571,0.030542806,-0.03492369,0.031223979,-0.0347702,-0.011441459,0.07596608,0.03951022,0.069804795,0.044273667,-0.06712367,0.022966107,-0.04424938,-0.0078739375,0.029432518,-0.094020575,0.021516884,0.033777256,0.075762555,-0.01005231,0.051020216,-0.017341288,0.054091,-0.033662505,-0.011221465,-0.048945446,0.0026416616,0.00601425,0.021341026,-0.08450248,-0.0554567,0.032631487,0.06455883,-0.008869858,-0.07433088,0.00451258,-0.02003795,0.013603498,-0.0461147,0.03637094,0.06577615,-0.040388253,-0.04599595,-0.09729196,-0.03742491,-0.047574744,-0.08251056,-0.024969468,0.03650578,0.0054844576,-0.056049947,-0.07986499,0.03923807,-0.04145567,-3.2556282e-33,0.122358,-0.10807479,0.093348354,-0.046581905,-0.060100283,0.015315789,0.040630084,0.027708296,0.030929139,0.07150731,0.014951338,0.059641715,0.0058537545,-0.011209205,0.029091602,0.01539466,0.024140876,0.10206449,0.0069254218,0.043669604,-0.013944406,0.056025792,0.0237614,0.0046264036,0.02262175,-0.026815413,-0.0082044685,0.02548634,0.004614397,0.021325868,0.020007601,0.008666708,0.00778038,-0.019890295,0.008641153,-0.01407524,-0.023833493,0.0057382626,0.00933122,-0.024314355,-0.040820956,0.02708192,0.06540427,-0.0077171167,0.03075412,0.022312084,-0.034510795,0.017887231,-0.06793331,0.029122883,0.00010633651,-0.071691714,0.022331111,0.05196864,-0.010683294,0.031805504,0.011220244,0.027746111,-0.08435612,-0.0032725884,0.020113714,-0.032303434,0.024968635,0.024255192,0.062619284,0.08759198,-0.021036103,0.03002169,0.024141544,0.018339222,-0.024906598,-0.015025918,0.035639767,0.0152949365,-0.024307525,-0.020800035,-0.11599905,-0.0022222337,-0.034594167,-0.02593566,-0.05609756,0.03415811,-0.034627233,-0.017308682,0.031859502,-0.03815284,0.0638971,0.20941965,0.0069601256,0.06888253,-0.02921052,-0.0401804,-0.039801504,0.097107835,0.094347544,-4.168077e-08,0.06412514,-0.026733711,0.049918447,-0.11623433,-0.00035482712,0.019667178,-0.004229628,0.019871281,0.010239882,-0.014160626,-0.023009354,0.068547584,-0.007857767,-0.02368086,0.008655816,-0.018940365,-0.045911137,0.034604568,-0.045972615,0.07374842,-0.07599573,0.04159376,-0.085211284,0.04264154,-0.045969997,-0.01613155,0.0556844,0.051027376,-0.06718416,-0.041440275,0.086617775,0.071213834,-0.032389283,-0.071825534,-0.093973316,-0.00918131,0.006342391,-0.06496058,0.052621666,0.048841856,-0.0059553552,0.0018761657,0.055509534,-0.031054957,-0.004658506,-0.008318985,-0.015151443,-0.052550264,-0.0083176885,0.14110355,-0.027885027,-0.03574344,-0.07999303,-0.046916336,-0.0899924,-0.07487088,0.0032761288,-0.018950574,-0.0009364442,-0.08038346,0.0032930542,-0.019444942,0.17984922,-0.008439324 +3.2.1.153,"Possesses one of the activities of EC 3.2.1.80, fructan beta-fructosidase. While the best substrates are the inulin-type fructans, such as 1-kestose [beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside] and 1,1-nystose [beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside], some (but not all) levan-type fructans can also be hydrolysed, but more slowly [see EC 3.2.1.154, fructan beta-(2,6)-fructosidase]. Sucrose, while being a very poor substrate, can substantially inhibit enzyme activity in some cases.",384,1.0,-0.022239631,-0.105668224,-0.05885805,0.030930912,0.111314215,0.0008298934,-0.09575204,0.054584194,0.06525481,-0.00070651935,-0.025506234,0.08810088,-0.003368746,0.057993725,-0.026044989,-0.0015975159,-0.028896509,0.054682765,-0.060878716,-0.01280635,0.04778468,-0.07654654,-0.016208144,0.05188441,0.017986748,0.023016023,-0.012479499,-0.048706707,-0.010918488,-0.052935548,-0.021383412,-0.060166,-0.0024100645,0.0046429657,-0.0049840575,0.079964496,-0.033944245,-0.040851198,-0.008549875,-0.041994907,-0.00958252,-0.012197005,0.0018839998,-0.027127026,0.015033086,-0.06508407,-0.07615681,-0.03285444,0.023761721,-0.034371715,0.006000986,-0.08838288,-0.046143316,0.059091426,-0.030206822,0.0019309791,-0.087062396,0.012003785,-0.00017104346,0.14825779,-0.019101318,0.046325807,-0.015666768,-0.03393931,-0.022485683,0.014617364,-0.034608256,-0.08539286,-0.029936843,0.06393553,-0.027728705,-0.03266665,0.0230796,0.040958412,0.0942782,-0.024016565,0.011449778,-0.00024544998,-0.020610152,-0.01258587,0.09169211,-0.020581983,0.058693193,0.020615183,0.014313393,-0.007024697,0.036935825,0.005770499,0.05670251,0.096313134,0.050046142,0.008062923,-0.04110867,-0.037755977,-0.012669433,-0.007252181,0.011869471,0.045329142,-0.00048880914,-0.007333467,-0.004529776,0.0042300452,0.035141967,-0.029538024,-0.038122777,0.011400176,0.021977725,0.025732718,-0.018042285,0.0032124845,-0.010162519,-0.036306743,0.0048366576,0.0736374,-0.09709663,0.02113867,-0.0075044157,-0.117014244,-0.003706951,-0.0058727097,0.06458808,0.04799527,0.14104258,0.0058267047,-0.05046938,0.078768216,-0.052731246,1.6850385e-33,0.033098698,-0.010038462,-0.0063283653,-0.03519996,-0.02827694,-0.018598102,-0.056325294,0.06195744,0.020159692,0.024221517,-0.034210812,-0.05165902,0.013468313,0.036005843,0.026653286,-0.0052137086,0.04709817,-0.06553931,-0.0067600943,-0.008867687,0.07086596,-0.027497876,0.006403439,0.001088851,0.018532671,-0.02104362,-0.08492749,0.1307282,0.07730972,0.0028494073,0.03336416,-0.066654086,-0.057485327,0.053348593,0.042976234,0.09123242,-0.04127079,-0.047568936,0.011749413,0.06709985,0.037489194,0.026595129,-0.0057505607,-0.05213716,0.011667901,0.020075193,0.00880924,0.10945241,0.020830661,0.025045695,0.0662182,0.02305957,-0.018430583,0.0041916487,0.013808376,0.031311702,-0.0023527385,-0.06257842,0.042990055,0.035106894,-0.10071327,-0.0035316097,-0.0076801446,-0.020606186,-0.046021983,-0.0056235874,-0.10895663,0.04044843,-0.08802061,-0.013374441,-0.035641592,-0.048570063,0.060871176,0.004409134,0.09348331,-0.043369744,-0.00012073756,0.022799253,-0.030497931,-0.019824468,0.036030535,-0.020431828,-0.05970571,-0.004570041,-0.065067045,0.0148803145,-0.009672249,-0.056423917,0.016472872,0.017523376,-0.06370172,-0.051269088,-0.03882427,0.07810327,0.018888393,-3.4881285e-33,0.10569763,-0.14667365,0.0768568,-0.0828882,0.00066543446,0.10652362,0.02208791,-0.06939535,0.08235876,-0.0776007,0.013663632,-0.018486276,-0.012319326,-0.05661715,0.011909795,-0.027642302,-0.07582341,0.043467272,0.018442314,0.04070184,-0.044379868,0.07058067,-0.05420042,0.06588164,0.050658043,0.014055538,-0.007643448,0.07789078,0.07359705,0.07961231,0.0012337206,-0.0054257507,0.029954987,-0.049103554,-0.056238834,0.0590841,-0.04029518,-0.04066832,-0.017047739,0.04607983,0.009172238,0.08017142,0.016064752,0.015912693,0.07355545,0.116027705,-0.0584501,-0.04387257,0.01140451,-0.016360048,0.01955571,-0.048664715,-0.07946553,0.07186482,-0.001769363,0.017216014,-0.02725196,0.035185013,0.0017286963,-0.067919225,-0.0023803199,-0.09844378,-0.016736323,-0.058572777,0.085017204,-0.03216701,0.0007635701,0.0724927,0.077908374,0.053842932,-0.015203552,-0.042805046,-0.010377914,0.021268368,0.0051908395,-0.0048727067,-0.10273294,-0.06596939,-0.028383479,-0.021714464,0.011629728,0.09072162,-0.071961656,-0.05430736,0.012463502,-0.038427383,0.009715697,0.12350476,-0.005023234,-0.04225234,-0.029202888,0.01621785,-0.016863337,0.10510441,0.12765715,-4.9919777e-08,0.043572795,0.008931332,-0.034448974,-0.0069314237,-0.0061880248,-0.02206059,0.031198356,0.007172135,-0.011397831,-0.016557707,-0.08797451,0.13473077,0.0012284361,-0.027507195,-0.024260242,-0.013628833,-0.017239982,0.020084562,0.038717825,0.02577209,-0.07054027,0.0009153382,-0.09923238,-0.022525504,-0.036152977,-0.107825026,0.07936691,0.068673,-0.09414654,0.038534924,-0.061289642,0.017624049,0.06689353,-0.063407615,-0.022867369,0.0068658213,-0.05227198,-0.006360404,-0.023503983,0.053227983,0.06867238,0.027611397,-0.019255828,0.025356514,-0.052087188,-0.072858386,0.044802092,0.06054267,0.00234774,0.012170538,0.0246005,-0.011379617,-0.09679838,-0.021613756,-0.029278273,0.021417258,-0.03840592,-0.034718722,-0.06639722,-0.075815044,0.009765756,-0.06520973,0.17886949,-0.005085537 +3.2.1.154,"Possesses one of the activities of EC 3.2.1.80, fructan beta-fructosidase. While the best substrates are the levan-type fructans such as 6-kestotriose [beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranosyl alpha-D-glucopyranoside] and 6,6-kestotetraose [beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranosyl alpha-D-glucopyranoside], some (but not all) inulin-type fructans can also be hydrolysed, but more slowly [cf. EC 3.2.1.153, fructan beta-(2,1)-fructosidase]. Sucrose, while being a very poor substrate, can substantially inhibit enzyme activity in some cases.",384,1.0,-0.02126023,-0.10047556,-0.066703185,0.031978857,0.09796763,0.0073769186,-0.10003973,0.06666258,0.06295677,0.0068712016,-0.018912077,0.09076382,-0.017105587,0.053321272,-0.0310025,-0.009566694,-0.031242834,0.049749956,-0.055773754,-0.0027315102,0.04191699,-0.07686821,-0.01661726,0.0369371,0.015394457,0.016279876,-0.021684013,-0.056067716,-0.003275317,-0.05259259,-0.032462012,-0.032834135,-0.013660178,-0.0035134524,0.007968518,0.07991902,-0.04723335,-0.037518125,-0.0126747,-0.059509188,-0.014409569,-0.0025821878,0.0064135985,-0.024364496,0.016758721,-0.06980235,-0.063083485,-0.013570895,0.021744069,-0.024895627,0.00514553,-0.08227998,-0.05167183,0.05461273,-0.029055027,-0.0108597325,-0.09076093,0.0039794026,0.011830031,0.14497155,-0.01586148,0.046297356,-0.018816741,-0.03766453,-0.015150248,-0.008523849,-0.038395595,-0.07627182,-0.03279926,0.059706602,-0.023595938,-0.04271324,0.03565579,0.060683288,0.09795458,-0.027379397,0.006610532,-0.0018752599,-0.0122586135,-0.005033442,0.0808904,-0.021784568,0.04166821,0.019798271,0.014923068,-0.022020968,0.04341966,0.015790015,0.056849506,0.09394794,0.05944185,0.022491708,-0.038190223,-0.05484536,-0.027301734,0.009535945,-0.0020011894,0.046777986,0.004839619,-0.0026133948,0.010251841,-0.00508121,0.018864254,-0.026227338,-0.031418696,0.001106277,0.0040168227,0.046187732,-0.025332997,0.0035721709,-0.0128309615,-0.04289367,0.018778898,0.06367116,-0.07515491,0.022541385,-0.007965947,-0.12315038,0.009999566,-0.003869743,0.062187944,0.059586428,0.15622537,0.02123359,-0.045293674,0.09003906,-0.041214492,1.8268938e-33,0.018173613,-0.018256295,0.008554216,-0.040268652,-0.030931003,-0.01907587,-0.058186866,0.046607535,0.005404691,0.0314773,-0.044310577,-0.062193602,0.018032284,0.028542848,0.038824648,-0.009920202,0.047907688,-0.054773536,-0.007602787,-0.012320687,0.0705177,-0.017244458,0.005964677,0.00041332046,0.024698421,-0.015091042,-0.08651812,0.13003932,0.06466232,0.0034589942,0.050121926,-0.060848042,-0.050438244,0.04973966,0.037878897,0.07435092,-0.046728753,-0.036501992,-0.015778067,0.06373138,0.04132102,0.03284812,-0.014788395,-0.042459156,0.020436706,0.016400225,0.013716387,0.112384245,0.016975371,0.020370137,0.06959617,0.017791048,0.008484211,0.009500028,0.016095653,0.05642663,0.0018412692,-0.065371074,0.055726696,0.03600067,-0.09695671,-0.0031564943,-0.016682608,-0.013788439,-0.04894073,-0.014443316,-0.10459737,0.050625335,-0.09328473,-0.013214873,-0.050172497,-0.04688727,0.067736365,0.010898114,0.10021717,-0.05036704,-0.00026760553,0.024114333,-0.057698756,-0.02115942,0.044318102,-0.011143414,-0.052932218,-0.010241938,-0.07321129,0.031598832,-0.030528346,-0.060613528,0.027719762,0.018653238,-0.05762742,-0.05556624,-0.052601203,0.08226385,0.027310463,-3.4599343e-33,0.10634987,-0.13363329,0.08398247,-0.07999654,0.011399753,0.09823338,0.042352185,-0.060627464,0.078719586,-0.07741774,0.008527503,-0.007279472,-0.022550872,-0.05656149,0.01794672,-0.00913323,-0.06856742,0.048986677,0.029412642,0.03489914,-0.057679847,0.06115827,-0.07065688,0.06605622,0.049802493,0.015701605,-0.008475562,0.06402439,0.07629399,0.0577882,0.007465627,-0.006629354,0.030647516,-0.039540324,-0.056633014,0.039110903,-0.03412631,-0.04661332,-0.03478459,0.055397183,0.014710007,0.09607893,-0.0010205061,0.013820175,0.07056065,0.08997239,-0.052078802,-0.042484958,0.0034625467,-0.011922822,0.019541671,-0.058324717,-0.077321246,0.07795497,0.0020595272,0.0020186007,-0.011737769,0.045146663,0.01085214,-0.043287456,0.008177299,-0.10444389,-0.009343478,-0.068725035,0.09636201,-0.03611272,-0.00888276,0.08583091,0.047822896,0.06221373,-0.04532045,-0.059978556,-0.020655595,0.0075160507,0.017166737,-0.006196469,-0.09251616,-0.05513842,-0.0170717,-0.0012863248,-0.0034268608,0.08696018,-0.06921989,-0.037312154,0.02172099,-0.042614188,0.0017378946,0.11255802,0.0067602787,-0.033632275,-0.03769012,-0.0066705644,0.0024871852,0.09495631,0.120451115,-4.997201e-08,0.04739682,-0.012299666,-0.042185128,-0.01884422,0.004250012,-0.021345625,0.020961905,0.018806778,-0.018971302,-0.020606712,-0.08983169,0.12693924,0.0012516484,-0.029457964,-0.037829094,-0.0113459565,-0.022182524,0.011846276,0.033590134,0.026077911,-0.07810789,-0.0019973258,-0.104925334,-0.008374673,-0.0330416,-0.10279323,0.07629612,0.07792409,-0.09161651,0.03496604,-0.07200566,0.020015046,0.053622045,-0.057164915,-0.024222683,0.021530801,-0.044419345,-0.012415887,-0.04044029,0.06356166,0.078492515,0.008245198,-0.018542208,0.016438466,-0.047898922,-0.05576733,0.04109787,0.066263534,-5.1529682e-06,0.023311488,0.008180141,-0.00950619,-0.10612829,-0.02345822,-0.019176118,0.010687003,-0.024284627,-0.04580405,-0.0624109,-0.07545611,0.032191005,-0.05760706,0.2013214,-0.00615883 +3.2.1.156,"The enzyme, originally isolated from the bacterium Bacillus halodurans C-125, releases the xylose unit at the reducing end of oligosaccharides ending with the structure beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose, leaving the new reducing end in the alpha configuration. It is specific for the beta anomers of xylooligosaccharides whose degree of polymerization is equal to or greater than 3. +The penultimate residue must be beta-D-xylopyranose, but replacing either of the flanking residues with glucose merely slows the rate greatly.",384,1.0,-0.04409753,-0.03292813,-0.08182698,-0.024737582,0.027967583,-0.009290288,-0.017947726,0.0074796537,0.054213863,0.013318706,0.052203983,0.0007062467,-0.032588974,0.059471186,-0.07593705,0.013280544,-0.034600113,-0.020343408,-0.008541346,0.02160278,0.04439451,-0.028572315,-0.003695984,0.053707685,0.0888179,-0.027881654,0.027614156,-0.14783971,-0.051452212,-0.06892828,-0.017226357,-0.037723858,0.082559,-0.03548278,0.07440084,0.07263831,0.01615289,-0.073567756,0.06472067,-0.021456372,0.035322804,-0.0069526667,0.019421002,0.0022425868,-0.07531672,0.03469204,-0.052517112,0.05178627,0.03893819,-0.0016751295,-0.03532941,-0.07297249,-0.071484536,-0.009752579,0.08171099,0.037034817,-0.060858227,-0.046173155,0.0059211696,0.05353845,0.04167963,0.060502492,-0.003175557,0.036057163,-0.08145465,-0.08968291,0.06741714,-0.09718715,-0.037400745,0.034214586,-0.086108975,-0.005994403,0.0071525965,-0.004188227,0.12012228,0.004562343,0.014076556,-0.05090415,-0.0058080023,-0.028788392,0.04433439,0.025891399,0.061302647,0.052924562,-0.026201515,-0.05758039,0.050870053,0.0046203635,0.0146857565,0.033142183,0.013112598,0.017163388,0.0020760652,-0.04780462,-0.057181627,-0.034481324,0.10361531,-0.019374883,0.0459756,-0.014997292,-0.027364245,-0.015716389,0.05348145,-0.054294832,-0.085778974,0.0026530838,0.012561018,0.090640165,0.061192267,0.047769204,0.03782143,0.015922181,0.050972994,-0.0070564835,-0.09692202,0.038854644,0.0029926472,-0.04458362,-0.06539333,0.041153524,0.029197792,-0.04159175,0.046425145,-0.0009905577,-0.086219974,0.09985862,-0.10752621,2.6429183e-33,0.060768194,0.05374246,0.020551814,-0.02150756,0.01713288,-0.03131704,-0.06230177,0.024820285,-0.028194074,0.0031441494,-0.074722864,-0.10594657,-0.027472064,0.07019543,-0.0045648296,-0.00988076,0.012093619,0.055957984,0.018378755,0.048302162,-0.044806104,0.035465576,0.0071140397,-0.018946417,0.10407947,0.03759517,-0.040889528,0.012820344,0.03781461,0.018161342,0.06511875,-0.03857874,-0.07199992,0.078430906,0.09094795,0.09482206,-0.018173676,-0.06844589,-0.01778891,0.028872339,0.00019734427,0.08642192,-0.0034896822,-0.03980266,0.0045796013,0.0038774072,-0.01990046,0.019856067,-0.0016083393,0.06999323,-0.0073174564,0.026581185,0.04067189,0.041169684,0.0018354206,0.0550667,-0.029507222,-0.02900244,-0.017581448,-0.03965382,0.012785874,0.035057515,-0.026232755,-0.033218198,0.041845612,0.0084852,-0.02685265,-0.050468408,-0.044811703,-0.021502221,-0.091167964,-0.038730588,0.043885626,-0.008737605,0.021594234,-0.023103485,-0.071885034,-0.008612311,0.038206533,-0.08147618,0.04800942,0.024637332,0.026733031,-0.119431876,-0.05529346,0.016584821,0.019436173,0.01939047,0.0023408832,0.0381439,0.003329031,-0.09502877,-0.06673447,0.02571699,-0.02308333,-3.777968e-33,0.08523047,-0.10746346,0.026064122,-0.025800956,-0.052762542,0.010965889,0.06638742,-0.07334506,0.012677325,-0.08582779,0.10516421,0.067784175,-0.03194152,0.009941458,0.028174829,0.052692126,0.027077977,0.059140146,-0.05940928,-0.031255674,0.0060700895,0.02144049,0.028869208,-0.040750526,0.012266035,-0.0012096667,0.006429541,0.04760984,0.0986218,-0.02645824,-0.03195739,-0.004299582,-0.008108601,-0.09770115,-0.043081835,0.023396496,-0.116893746,-0.0041690012,0.012439116,0.041578643,0.042204093,0.06203776,-0.007361881,-0.014556269,0.08205881,0.06860594,-0.025319321,0.007184698,0.06303996,-0.04992721,-0.0012746453,-0.039316777,0.014206982,0.017562376,-0.0014259159,0.04239817,0.045719072,0.070027724,-0.022415157,-0.09960152,-0.077227525,0.004280311,0.08474232,0.011830176,0.05660017,0.056108333,-0.0006620441,0.0031681207,0.039488733,-0.067291155,-0.0044153198,-0.06015282,-0.03083276,0.054379553,-0.036943614,-0.021634936,-0.114159934,-0.06720193,-0.008539656,-0.0073414464,-0.011292504,0.02535705,0.02196493,-0.058982864,0.019167963,-0.0922747,0.06024801,0.05591849,-0.0024633666,0.033195104,-0.022025784,0.039742652,0.052997097,0.033416867,0.13168734,-4.2629466e-08,0.018324798,-0.031831067,-0.05766367,-0.01423075,-0.002321721,0.0058837105,-0.002052503,-0.004296807,0.04525702,-0.07730556,-0.0074793515,0.15032339,0.0071851932,0.059542615,0.018939802,0.00463098,-0.025476279,-0.045018055,-0.015360464,-0.009034162,-0.16554776,0.037312206,-0.08026656,-0.03167707,-0.038695905,-0.09328753,0.060579788,0.05896341,-0.055702664,-0.014424247,-0.028762199,0.09451039,-0.018236618,-0.045839556,-0.04352071,0.030443221,-0.09474666,0.011657656,0.07138375,0.04730609,0.038650103,-0.051432095,-0.0614281,0.012352422,0.005238945,0.059070613,0.019463295,0.067600526,-0.06640561,0.033166632,0.02907621,0.013301392,-0.084143005,-0.077611536,-0.04850766,-0.0033350552,0.008563822,0.0029119684,0.00022214201,-0.048547775,-0.011492211,-0.06712111,0.15435155,-0.05283221 +3.2.2.1,"The enzyme from the bacterium Ochrobactrum anthropi specifically catalyses the irreversible N-riboside hydrolysis of purine nucleosides. Pyrimidine nucleosides, purine and pyrimidine nucleotides, NAD+, NADP+ and nicotinaminde mononucleotide are not substrates [6].",384,1.0,0.0034218447,0.015860204,-0.090876445,-0.018669752,0.022959346,0.0560352,-0.07925373,-0.0032558183,0.0077274325,0.002576744,-0.039791472,0.00041661,-0.13700263,0.022841806,-0.053828903,0.005613222,-0.05238676,0.051286187,0.11441092,-0.02789931,0.02456737,0.043381307,-0.035282638,-0.04896458,0.042227615,0.013771942,0.0361914,0.0031657012,-0.02668974,-0.10075292,-0.001125109,-0.08523403,0.06569494,-0.07589234,0.11325979,0.09315681,-0.08799662,-0.04417943,0.07066172,0.026645457,0.011099779,-0.014687598,-0.027840003,0.005260096,-0.055307258,-0.01074615,0.044011027,0.09259581,0.016820204,0.022338552,-0.046142064,-0.009265595,-0.033385064,-0.045717414,0.028787406,0.004421674,-0.036469884,-0.0875238,-0.009056866,0.014274032,0.03319914,0.0076218164,0.0010828552,-0.0038272762,0.016380984,-0.02814149,0.10962259,-0.018093653,-0.0039461483,-0.011853664,-0.0027734484,-0.050166726,-0.039678268,-0.0046129725,-0.013935398,-0.011270961,-0.040104937,-0.045606773,0.05875784,0.06082733,-0.056520697,0.02786129,0.00892865,0.024101766,0.06708149,0.04279456,-0.058654744,0.031085065,0.061205585,0.06375604,-0.018003644,0.015178978,0.058395732,-0.05632148,-0.027755555,0.03849403,-0.036124267,0.025134282,-0.02088389,-0.06229196,0.004164647,0.09315047,-0.06427578,-0.11289383,0.005155247,0.07083841,0.044824243,-0.00036838854,0.02306352,0.042386103,-0.052554514,0.038113855,-0.04194779,-0.038235173,0.016181206,0.05568308,0.018532157,-0.057587698,-0.067013726,-0.0107941935,-0.04283992,-0.021965511,0.026499262,0.07480121,-0.034405395,0.04492093,-0.020918678,6.9913386e-33,0.07181876,0.024507187,-0.024149025,-0.03332045,0.023890251,0.029840833,-0.057980724,-0.008853772,-0.03491755,-0.0046001887,-0.09602706,-0.10406956,0.034743406,-0.023950811,0.027043449,-0.024042597,0.021412183,0.06568808,0.020732492,-0.0075748544,0.009152448,0.074645765,0.009858366,0.010614419,0.009008043,0.10864168,-0.04238231,0.012027903,0.07331179,-0.04258448,0.012836894,-0.04771459,-0.105170235,0.017269893,0.06100822,-0.033214945,-0.07928243,0.02869822,0.015768863,0.10024374,-0.048615173,0.058101494,-0.013436801,-0.053124595,0.050322417,-0.014085433,-0.019015307,0.027044838,-0.009056539,0.009984986,0.01759866,-0.04248912,0.10783624,-0.061621945,0.031462226,-0.010776048,0.00016436948,0.01893385,0.022056248,0.08335344,0.030585332,-3.2985055e-05,0.055086747,-0.055690404,-0.032971296,0.03082553,-0.04189886,-0.057947315,0.09859757,0.040856086,-0.031249685,-0.026816366,0.03749514,-0.02529141,0.014237911,-0.018037725,-0.06158482,-0.0039421157,0.03845038,0.003236001,-0.030209502,-0.0011846273,0.025405113,-0.04639511,0.052101802,-0.016000422,-0.021191988,-0.068340056,0.027171817,0.06305976,0.086500265,-0.06046132,-0.06735085,-0.02543379,0.018243976,-6.881065e-33,0.09388848,-0.117239185,-0.04064318,-0.13340656,-0.15382999,0.013928579,-0.036147315,-0.053824026,-0.042776216,-0.0050687315,-0.008858189,-0.030000402,-0.00060796586,-0.052676015,-0.046649564,-0.016199246,0.07990973,0.09586205,-0.01626797,-0.023755146,-0.077846006,0.077203706,0.037064657,-0.037788797,0.035943832,0.005470832,0.031266235,-0.018906072,0.124833934,-0.03255001,-0.014964895,0.017330922,-0.06210794,-0.015269039,0.035553202,0.08350139,-0.027204478,0.0657706,0.045793552,-0.025676033,0.092061505,0.0658575,-0.043119993,0.05406333,-0.004738969,-0.010285372,-0.11948479,-0.042082008,-0.06665383,-0.04780286,0.08788121,-0.017862236,0.04031273,0.011354262,0.04368942,0.009171254,0.021835083,-0.0005517538,0.07406782,-0.048571326,-0.0805155,-0.048011407,-0.010394961,0.017697068,0.06767287,0.083128095,-0.06920761,0.09450949,-0.03049752,-0.022711923,0.016902708,0.044201735,0.020154726,0.030545846,-0.018519158,-0.021254478,-0.036608923,-0.032720488,0.027890857,-0.074411035,-0.012263763,-0.036609925,-0.07870454,-0.083487794,-0.014931807,-0.06409657,0.09690878,0.07001124,-0.008908106,0.06117819,0.0331646,-0.036639623,-0.015757497,0.10687275,0.028642522,-3.8060076e-08,0.02653912,-0.018619629,0.0020754898,-0.034931276,0.004170042,0.036881726,0.006671334,0.008080868,0.041725595,-0.00946459,-0.025069764,0.098354355,0.106575616,0.0056355046,0.07609097,0.0601517,-0.046334017,-0.05902399,0.0036157314,0.015282134,-0.036294594,0.058296602,-0.1677084,0.0900244,-0.0095772045,-0.026863692,0.052401673,-0.041811477,0.061272968,-0.038285326,-0.017491724,0.03256047,0.049161147,-0.08095233,0.02531714,-0.03244745,0.03399038,-0.053746887,-0.0026980536,-0.02803843,-0.07091498,-0.047861252,-0.045612086,-0.010458398,-0.026394958,0.026743818,-0.021436548,0.032515947,-0.03977254,0.039502133,0.027771145,0.018651044,0.03168006,-0.06010356,-0.0998764,-0.018929547,0.023786489,-0.058777694,-0.010849975,0.001982353,0.03630487,-0.012928275,0.15945844,0.01646239 +3.2.2.5,"This enzyme catalyses the hydrolysis of NAD+, without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase). The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis. The enzyme from the venom of the snake Agkistrodon acutus also catalyses EC 3.6.1.5, apyrase [3].",384,1.0,-0.026100246,-0.054013506,-0.13212645,0.026996557,0.045555573,0.034052778,-0.07104186,0.06685936,-0.011702542,0.001978451,-0.01948191,-0.005511219,-0.019024337,0.104281135,-0.08164503,0.006064971,-0.027211685,-0.02249096,0.096918665,-0.01481353,0.04868436,0.026155425,0.008737613,0.0027027524,0.028332017,-0.00034174664,-0.047684826,0.0013474345,-0.06532455,-0.050048735,-0.039524097,-0.09567699,0.039945617,-0.10034844,0.09556381,0.049102966,-0.08637435,-0.010087792,0.038823713,0.021185674,0.011984187,0.05134226,-0.01733981,0.014893095,0.0024270678,-0.022829292,0.049921744,0.08830974,0.082212605,-0.035451423,0.0031966874,-0.003937296,-0.08219786,-0.040503126,-0.008546914,-0.041992385,-0.06443224,-0.081087984,-0.0038228477,-0.07261085,0.028807787,-0.008885352,0.011055913,0.035094403,0.0073246616,-0.050316222,0.01892704,-0.03353709,-0.01090541,0.0056902566,-0.08170151,-0.053475983,0.006834145,0.006683334,0.012598762,0.080748625,-0.0040032826,-0.051163353,0.009991483,0.044141743,0.0713919,0.034122232,0.023808949,0.08799625,0.064831674,0.046835057,0.05657649,-0.011885426,0.03165753,0.040840946,0.06171361,0.013034836,0.017172087,0.017622741,-0.0441653,0.01441891,-0.00807945,0.060308285,-0.071220696,-0.015796095,-0.032985486,0.011680222,0.007637462,0.009066566,0.060989667,0.02099516,-0.046263855,0.10228639,0.07636988,0.02079853,-0.049591824,0.015842075,-0.03482926,-0.10236325,0.027383193,0.09275831,-0.027706765,-0.10457777,-0.0024290634,-0.015438432,0.07925765,-0.037573226,0.022909323,0.04945272,0.05489662,0.00058635185,-0.15531692,3.2117202e-33,-0.00075447344,0.024545737,0.037973516,-0.029091833,0.059777148,-0.0064046704,-0.14664796,0.01307745,0.018760445,0.01135913,-0.06224354,-0.072728,0.09419231,0.010949171,-0.064337775,-0.011018273,0.010942302,-0.0007387048,0.019748725,-0.08427366,0.053945925,0.010659343,-0.03965127,0.035474636,0.0041770227,0.07080665,-0.06485253,0.06814994,0.06707108,0.0012063306,-0.020322764,-0.13043864,-0.09267879,0.031391107,0.014155099,-0.0050357054,-0.050202996,-0.11138886,0.055399034,0.034048863,-0.060826562,0.026302973,0.005826527,-0.02609298,0.061302815,-0.08878058,-0.07834676,0.09966558,-0.0143784005,0.053505115,0.0756344,-0.07723035,0.12948984,0.0392391,-0.070593685,0.049173485,-0.03070678,-0.055995595,0.034613993,0.034747463,0.02625418,-0.009889823,-0.048762724,0.011508905,-0.053849556,-0.0024924965,-0.017773844,-0.028351123,0.078564316,0.04939087,-0.057689507,0.061944116,0.045060888,-0.02702032,-0.019606408,-0.01653459,-0.005204775,0.008705876,-0.019302046,0.06875063,-0.059866704,-0.037058346,0.0451531,0.019463586,0.04847336,0.062212113,0.020295996,-0.07016048,0.05242926,0.10552433,0.04498921,-0.040495265,-0.06570574,0.009205227,0.027413266,-3.3921538e-33,0.08660313,-0.0672514,0.059669748,-0.13556807,-0.044765186,0.021035807,0.02720644,0.034388382,0.014939286,-0.092899896,-0.006218551,0.0075100805,0.0074723163,-0.009273823,-0.0033119374,-0.024878688,-0.0012749255,0.07928044,0.038542405,0.04317515,-0.0043281517,0.08499972,-0.002071784,-0.035524923,0.07732508,-0.04693298,0.02236894,0.022757944,0.024374653,0.03363963,0.016261728,0.036927048,0.00016057977,0.020887068,-0.026644442,0.03655506,-0.05519172,0.009321734,0.0402903,0.00088170695,0.05087694,0.04646086,-0.035133503,0.020169694,0.084597856,0.09678265,-0.016254544,0.08693213,0.032047085,-0.05621534,0.07063289,-0.005593304,0.0068242857,0.053638764,0.045502536,-0.005619622,0.08285761,-0.012154305,-0.018919367,-0.0058185984,-0.01253156,-0.040398445,-0.047055073,0.038228784,0.103398554,0.061916247,-0.018844172,-0.0038936771,0.0044194744,-0.021464465,0.04666485,0.004881396,-0.09911079,-0.01908318,-0.012697004,0.012747804,-0.07310373,0.051009428,0.027939068,-0.023967426,-0.008506755,0.017281765,0.048601408,-0.0019911826,-0.0686024,-0.05295147,0.030633355,0.08777121,-0.023373557,0.017357504,-0.030152721,-0.005933366,0.02258343,0.031464692,0.018428242,-4.0492246e-08,-0.0056443354,0.04629168,0.02141357,-0.10308151,0.007595619,0.07990654,0.0055074086,-0.11352569,0.052274194,-0.018308435,0.008471975,0.040972315,0.021381916,-0.04917713,-0.011221538,-0.041829795,-0.05455175,0.018810954,-0.012534384,-0.033527866,-0.10785912,0.057076193,-0.07729401,0.021669198,-0.010465108,-0.06364639,0.026503816,-0.0056413505,0.028468128,-0.0036768015,-0.024762029,-0.014671618,0.010592564,-0.07064921,-0.08995964,-0.014517416,-0.027651204,-0.049052063,0.03061093,0.0026091759,0.020615755,-0.066350356,0.011541432,-0.052101262,-0.08348669,0.011787818,0.026263963,-0.037151285,-0.035432026,-0.038452346,0.10147425,0.024462666,-0.03240185,-0.09813479,-0.052893985,-0.0140775535,-0.0042194086,-0.07928712,-0.08854457,-0.04744866,0.03799313,-0.01141131,0.15005076,-0.011943183 +3.2.2.6,"This multiunctional enzyme acts on NAD+, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD+ glycohydrolase.",384,1.0,0.004658748,-0.0031443702,-0.03682726,-0.017323582,0.018268434,0.025719639,-0.066245005,-0.0036622835,0.06510645,0.061891843,-0.019176092,0.0137440115,-0.03503972,0.075115785,-0.031150198,-0.02456222,-0.054118454,0.018833557,0.02730469,-0.03269357,0.08314133,0.028616305,-0.0055493983,-0.0015947737,0.008261023,-0.008222107,-0.0347793,-0.0045227963,-0.031068258,-0.018027855,-0.025787627,-0.04991818,0.02791025,-0.035874534,-0.0032980526,0.08714497,-0.07676806,-0.056917433,-0.083063744,0.015369331,0.02885253,0.024678271,-0.017520636,0.010226055,-0.009365344,-0.015332136,-0.014857044,0.041152515,0.023881845,-0.007613649,-0.025761513,-0.028292907,0.0041864817,-0.027538517,0.01969389,0.07335681,-0.06515547,-0.026693583,0.027893018,-0.046245288,0.018545356,-0.013277316,-0.02576938,0.031626318,0.06582799,-0.036485616,0.040121723,-0.044679347,-0.027692901,-0.031837773,-0.09297025,-0.049052894,-0.013241036,0.0028599398,0.052787818,-0.027577499,-0.058838036,-0.047661472,0.09567124,-0.04983338,0.07405158,-0.057999767,-0.055828407,0.013963894,-0.0062193046,0.07061889,0.047190543,0.009405151,0.019950885,-0.0111036105,0.01683288,-0.0044501736,0.047894426,0.012497134,-0.1203407,0.022305308,0.01554699,0.09500861,-0.010753638,-0.07242525,0.061608404,0.18796986,0.0018869141,-0.09569609,-0.0061367606,0.06621618,-0.035157613,0.103493296,-0.031508695,0.023762478,-0.0012139804,0.019738298,-0.040808342,-0.047647182,0.0036236963,0.18941757,-0.035783555,-0.056885377,0.0013131879,-0.04362335,0.033307254,-0.100043185,-0.033781826,0.03468818,0.0027262461,0.0527935,-0.09674483,1.1484625e-33,0.047158215,0.019347591,0.033788033,0.020164931,0.032417454,0.015104042,-0.10687981,0.015587813,-0.04912337,-0.028661532,-0.031431843,-0.060142048,0.044239104,0.054971017,0.012023566,-0.030533928,-0.042694498,-0.062559076,0.066834204,0.045731936,0.073284656,0.030962108,-0.02609945,0.062966324,0.047935247,0.060426317,-0.04254856,0.03699182,0.0829761,-0.0012538807,0.029440967,-0.06908987,-0.11902763,0.0015488499,0.06094146,-0.032042272,-0.031590488,-0.008842864,0.07354921,0.10480717,-0.021797169,-0.030980691,0.0693625,-0.028600918,0.046354692,-0.054944627,-0.051012956,0.04096492,0.04570454,0.052707843,0.077867255,-0.06836727,0.079852276,-0.039571885,-0.037320964,0.044045232,-0.082102045,-0.07109403,-0.039370727,0.03429001,0.020396976,0.021939738,-0.02167201,0.06891588,-0.07424265,0.024190107,-0.05564602,-0.116845354,0.005763461,0.04252206,-0.052193295,0.008049995,0.12455409,-0.052588936,0.012204972,-0.025853679,0.01171555,-0.008048202,-0.017011467,0.031025225,-0.043435924,-0.05794362,0.0009063559,0.06927342,0.075254306,0.0024660018,0.002464165,-0.053599324,-0.041438587,0.10440421,-0.012701643,-0.023793044,0.016337262,0.03492762,0.007460576,-3.2270516e-33,0.15155882,-0.058107387,0.07519625,-0.090806045,-0.027981851,0.045454744,0.0054101697,-0.093694545,0.039334834,-0.109213345,0.010317815,0.067751184,0.1034138,-0.024752244,-0.008214218,0.00624105,0.0025781798,0.0480508,-0.055526692,-0.00040236,0.0345073,0.08155618,0.023686212,0.013399275,0.0972054,-0.058828663,0.00713154,0.031463124,0.03946804,0.042069215,-0.04866371,-0.033668533,-0.009144202,0.0071502775,-0.03366958,0.048839964,-0.03718407,-0.0006242227,-0.0027672169,0.06545839,-0.050340965,0.04565236,-0.055772662,0.023089455,0.05702965,0.08260237,-0.020092422,0.018766697,-0.06417843,0.0018416629,0.05128216,0.0027538938,-0.05442526,0.0920882,0.041499633,0.07723189,0.040395387,0.08891648,0.005739139,0.0029932752,-0.055459652,-0.018042581,-0.017440999,-0.049701456,0.07920677,0.03739475,-0.03215613,0.0036843817,0.0004798338,0.004655678,0.04730534,0.003586022,-0.039680257,0.0092768315,-0.003028691,-0.015944313,-0.13019797,-0.032073766,-0.02893096,-0.025349852,-0.018360961,0.013574957,0.055058055,-0.012143112,-0.017507808,-0.094859645,0.016868021,0.09379484,-0.054731566,0.01896222,-0.055844583,-0.0045734607,-0.011561934,-0.007984432,0.030096382,-4.0296705e-08,0.023185935,0.020996148,-0.036990788,-0.15313278,0.04164677,0.011106698,0.044650804,-0.013947617,0.027192384,-0.035089336,-0.022349706,0.06358086,0.02880359,0.013350713,0.020236883,0.02381801,-0.046536267,0.0358258,-0.051143818,-0.033204224,-0.06510014,-0.004144399,-0.13417168,0.072017126,-0.06915524,-0.032157805,0.037496347,0.03313144,0.040478934,-0.02417176,0.011750372,0.014029777,0.031346157,-0.092146955,-0.08210625,-0.011354,-0.031955414,-0.018515538,-0.0108649535,0.014676539,0.006163805,-0.09004496,-0.022600256,0.033034395,-0.032621842,-0.0024099036,0.024866056,-0.036614235,-0.018227553,0.06546912,0.048157066,0.023034705,-0.0128874155,-0.09681609,-0.08256242,-0.011607594,-0.05383366,-0.08597018,0.011339143,-0.029393295,0.022913776,0.014687192,0.12125614,-0.053356852 +3.2.2.7,Also acts on adenosine N-oxide.,384,1.0,-0.027325602,-0.032756746,-0.0071398546,0.056834787,0.034901816,-0.029283678,0.004409507,0.029309334,0.077773534,0.017626546,0.017961275,0.07902957,-0.060379572,0.077677324,-0.03233982,0.06931021,-0.017045481,0.056031678,0.030816322,-0.08517348,0.06769662,0.01481932,0.032510247,-0.016242089,0.00023646049,0.035147198,0.04551451,0.048788924,0.031679306,-0.07563195,-0.045721684,-0.0105574215,-0.019951869,-0.012687256,-0.010204569,0.10684946,-0.06375712,0.022756733,-0.009396013,-0.011095384,0.0509939,-0.072645605,-0.0076730084,0.015411309,0.04238147,-0.026019007,-0.0082530435,0.043463133,0.06344914,0.043445814,0.012196672,-0.060134314,-0.0087916665,-0.014788729,0.0010944754,0.03152354,-0.16441359,-0.0036529577,0.027982328,-0.016778411,0.016283646,-0.0031767045,-0.011190209,0.064647324,0.13184273,-0.01366485,0.048979748,-0.028765034,-0.04521474,-0.0011649332,0.044802997,-0.02319846,0.06166021,-0.03452988,-0.00064906414,-0.0072987694,-0.05689918,-0.05505437,0.019803915,0.014064553,0.048024457,0.08656101,0.036194257,0.022504564,0.05643047,0.035953563,-0.007434352,-0.045750625,-0.097010076,0.022029448,-0.0050916835,-0.015820643,0.025379669,0.03575549,-0.0023312424,-0.036031958,0.0012551114,-0.0030041626,-0.05378201,0.00022488668,-0.029467514,0.09807175,-0.08264875,-0.054246373,-0.028366696,0.044015728,0.025009243,0.0036387716,-0.013052433,0.08838145,-0.0341944,0.049413435,-0.038581382,0.0034490447,-0.02939905,0.074407764,-0.0280518,0.013919364,-0.07111831,-0.02043684,-0.048944592,-0.11328696,-0.09528225,0.021827636,-0.052287553,0.059351478,0.020697918,-1.0525528e-33,0.07792373,-0.05202228,0.01776412,0.020750904,0.077291176,0.005160699,-0.04022443,-0.056630544,0.02226546,0.0012412147,-0.03181855,-0.02237111,0.076978706,-0.020122336,-0.030706432,-0.03265257,-0.060343232,0.05930353,0.055602934,-0.009582874,0.005257182,0.04614557,-0.05554226,0.01008924,-0.0558318,0.03147498,-0.09823872,-0.016765488,0.043231897,-0.031323977,0.0064965473,0.013003064,-0.07109038,0.02512906,-0.030518191,0.03029751,-0.10219336,-0.041751023,0.031965815,0.084488355,-0.06655804,0.048238393,-0.047438662,-0.027090048,-0.0009053614,-0.08567522,-0.04959287,0.04426293,0.03571009,0.04249925,0.03294339,-0.044853535,0.04125122,-0.06188772,0.02945517,-0.023500945,-0.005710677,-0.06242073,-0.032994043,0.057698734,0.023859754,-0.0030929786,-0.003260323,-0.034631155,-0.03597624,0.05479395,-0.087962195,-0.05649065,0.0067921244,0.030209959,-0.030804183,0.045685764,0.080138594,-0.019852519,-0.058668822,0.00033934927,-0.003977642,0.01998026,0.0032552993,0.01401246,0.03675922,-0.091586135,0.082229555,-0.049624383,-0.015698943,0.013418493,-0.015485102,-0.08210661,0.0010181147,-0.011937438,0.09762145,-0.04905983,-0.058890544,-0.059104577,0.022203254,-5.2165335e-34,0.050972033,-0.09054573,0.0067706024,-0.035733007,-0.03722068,0.03501916,-0.04650722,-0.0667067,0.0048379027,0.0029867967,0.051733933,0.0077330596,0.007177399,-0.023682741,0.021843072,0.0035229183,-0.0015016468,0.048548874,-0.04382025,0.00796642,-0.030078545,0.10994996,0.07076519,0.07981732,0.03989559,0.0060054515,-0.06551093,-0.026910516,0.0663861,0.043221913,-0.02405174,-0.037180886,-0.15123393,-0.0026694383,0.059055332,0.030574666,0.039674807,0.042104956,-0.025930606,-0.0719415,0.077521354,0.029110447,0.09522402,0.09539111,0.019188562,0.07632817,-0.014573015,-0.017425276,-0.091287255,-0.03804894,-0.002208011,0.00066417054,-0.050181694,0.09054133,0.062386263,0.1267994,0.0361592,-0.03900265,0.0127228545,-0.010711076,-0.022222955,-0.050308246,-0.056877874,-0.08653247,0.03685641,-0.0066681406,-0.08488152,0.06594666,0.0751433,0.022776963,0.077151366,0.01313613,-0.008424527,0.016088918,-0.13359171,-0.022085272,0.021157397,-0.11584449,-0.028702129,-0.041565895,-0.06600264,0.015936604,-0.033713482,-0.07428916,-0.02089315,0.01855502,0.050109986,0.02607103,-0.0393364,0.076764226,-0.013822819,-0.048549958,-0.034827348,0.03834337,-0.022570206,-1.6498126e-08,0.020920375,-0.059630018,0.09135281,-0.05594748,-0.00077174953,0.011490331,0.07419257,0.057102505,0.031329658,-0.06156291,-0.020636594,0.10392411,0.09178938,-0.0067968615,0.089208394,0.008085345,0.0152887665,0.019228503,-0.055123318,-0.094607405,-0.12765504,-0.05009233,-0.025622468,0.07471762,-0.008808414,-0.01536596,0.10798466,0.08796322,0.029539203,-0.043364264,-0.018917257,-0.045505304,0.032781076,-0.051084477,0.016383868,0.03338561,0.107907474,-0.013407682,-0.06845359,-0.019040823,-0.041729737,-0.06554179,0.01444755,0.06811514,7.193677e-05,0.021054719,0.014192646,-0.014354898,-0.028220205,0.032413103,0.06250554,-0.052996535,-0.0108527625,-0.013373065,-0.08748612,0.0031360101,-0.016315244,-0.026119778,0.10641006,-0.0059798,-0.014434278,0.020473635,0.16504268,-0.008161667 +3.2.2.8,"Also hydrolyses purine D-ribonucleosides, but much more slowly. 2'-, 3'- and 5'-deoxynucleosides are not substrates [3].",384,0.99999994,0.022999173,-0.13616061,-0.0057741813,-0.09994891,-0.01684471,-0.029439766,-0.06107548,0.024872126,0.019582206,-0.0042350576,0.029893093,-0.0062345783,-0.034804977,0.08906465,-0.056691334,0.0049680355,-0.04878914,0.050960448,0.049239866,0.020369386,0.042026006,0.017982712,-0.021693744,0.03152622,0.06785093,0.04221875,0.02280713,0.012521404,-0.011712357,-0.055199806,-0.03646324,-0.030146291,0.00074752304,-0.00019678567,0.051463153,0.09107153,-0.03901389,0.020168897,0.050910685,0.024676913,0.025122944,-0.011086735,0.028606277,-0.006470881,-0.024620477,-0.027829407,-0.063078664,0.049675953,-0.010293499,-0.005240695,0.059555702,-0.04795235,-0.036979023,-0.003044432,-0.011208926,0.028633106,-0.09300072,0.05887726,-0.014084164,0.030844865,0.0037173154,0.021814829,-0.03718553,0.022150863,0.019316306,0.024393708,-0.0044158897,0.0054199365,-0.03983148,0.03067814,0.014817258,-0.029983653,-0.024847899,0.013448328,0.010262192,0.004139081,-0.002678418,-0.091009915,0.024893828,-0.0562901,-0.035581656,0.012887711,0.062742405,0.06394935,-0.004235406,0.041107714,-0.062851615,-0.015945064,-0.06672204,-0.0052497797,0.046134416,-0.0006804799,-0.0030159939,-0.0017670308,0.0100931795,0.02046851,0.027313614,0.062390633,-0.023763295,-0.0771719,0.0024577437,0.0726125,-0.08056191,-0.02362188,0.03252662,0.0689501,0.050070014,-0.011099039,-0.0029069865,0.0017709403,-0.024169836,0.02327883,-0.036813557,-0.032971207,-0.01592755,0.01129882,0.01914143,-0.048330702,0.039676033,-0.059837047,-0.018222572,-0.027452733,0.045264285,0.04298911,-0.06907806,0.048632827,0.059035484,2.7848668e-33,0.018264605,-0.05087526,0.046113815,0.035160627,-0.03193828,0.03268682,-0.0772789,-0.015603541,0.029033307,-0.0152018815,-0.18418555,-0.008402499,0.04029504,0.030180605,0.056802504,-0.083980724,0.010391287,0.014094846,0.06061791,0.0251412,0.020499578,0.08032811,-0.03291988,-0.007962923,0.009362811,-0.03794292,-0.08711544,0.015995687,0.06620763,-0.031332206,-0.052518107,-0.04718245,0.016970452,0.06465014,-0.053796038,0.034180548,-0.098306976,0.017107204,0.06571231,0.04633262,0.021111464,-0.05241363,-0.004380954,-0.07346129,0.029260317,-0.004975259,-0.020195136,-0.031760253,-0.10202891,-0.004323508,0.08035061,0.028037382,0.02512794,-0.09006135,0.03268944,-0.016890323,0.031727936,0.03236545,0.055637006,0.15193638,-0.009558714,0.09031563,0.012252247,0.005628533,0.012925214,0.051299796,-0.10981518,-0.042469814,-0.020732412,0.04569551,-0.04257834,-0.013231799,0.062249802,-0.07353043,0.0668891,-0.016664794,-0.011468755,0.013728696,-0.02066317,0.020443698,0.013419478,-0.051934928,-0.021626784,0.0307052,-0.01355283,0.040560186,0.030532042,-0.0753671,0.009536892,0.08194832,-0.020258212,-0.031488325,-0.04546754,-0.033591293,0.040551137,-4.8921305e-33,0.059651263,-0.10298932,0.037870385,-0.06749974,-0.08324861,0.0733886,0.042154036,-0.023296759,0.06383749,-0.0053560534,0.06521046,0.043314043,-0.123458564,-0.07331457,-0.07082888,0.06317566,-0.021415299,0.041161563,0.0067757843,0.00093113503,0.015763158,0.1186767,-0.018528748,0.06755845,0.030967575,-0.05144232,0.048602223,-0.043217096,0.066666484,-0.005865486,-0.020377982,-0.027304117,0.035304736,0.013391876,-0.019397216,0.056573495,-0.04484903,0.012602668,-0.05122491,-0.06687097,-0.04209908,0.070900954,0.02084169,0.078564465,0.04047061,0.0705332,-0.1036992,-0.060382456,-0.060123082,0.002250163,-0.03657118,-0.052346773,-0.011595341,0.05802802,0.044233996,-0.016101256,0.021130275,0.007321332,0.08851251,-0.0283534,-0.07800564,-0.05762115,-0.041864265,-0.09350061,0.05567305,0.030309198,-0.10784013,0.07392711,-0.002687279,-0.021489447,0.03575474,-0.014208041,-0.05194145,0.013661279,-0.06270781,-0.074876346,-0.040417753,-0.031687636,0.03642883,-0.025388155,-0.03596761,0.045032207,-0.050793044,-0.019549154,0.045436505,-0.09565281,0.045408573,0.047859915,-0.034871574,0.107394315,0.07345386,0.0060372613,0.03774951,0.058012992,0.07144349,-3.3106094e-08,0.07489199,-0.043145373,0.034727275,-0.06157141,-0.04066887,-0.0127411,0.061295208,0.07645424,0.048986353,-0.07222137,-0.023475379,0.062439594,0.0151397595,-0.022178683,0.06427095,0.06358077,-0.09176228,-0.073330455,0.01569758,-0.0022246193,-0.07056528,0.023790374,-0.118679635,0.053217746,-0.05848936,-0.01914309,0.102181986,0.009108473,0.04268446,-0.017315354,0.07046567,0.019386888,-0.0055317944,-0.13241985,0.0712362,0.0142981205,-0.030251097,-0.0041236863,-0.039958995,0.048655402,-0.09070957,-0.1265507,0.022632087,0.003009438,0.029948238,-0.046110675,-0.017629862,0.06644435,0.040261332,0.030290008,0.03575436,-0.02128734,0.010707567,-0.11351395,-0.055322517,-0.013505177,-0.03148873,-0.09301722,-0.0041667195,-0.047316745,0.0073363143,0.034162365,0.180243,0.03706644 +3.2.2.9,"This enzyme, found in bacteria and plants, acts on three different substrates. It is involved in the S-adenosyl-L-methionine (SAM, AdoMet) cycle, which recycles S-adenosyl-L-homocysteine back to SAM, and in salvage pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are produced from SAM during the action of many enzymes. cf. the plant enzyme EC 3.2.2.16, methylthioadenosine nucleosidase.",384,0.9999999,-0.057396445,-0.060334336,-0.11441177,-0.012052612,0.11899062,0.10530167,-0.089593165,-0.0008605278,0.058257345,0.048889317,0.074282,0.008666564,-0.03592714,0.003062326,-0.021469643,0.082652085,-0.11522187,0.040328342,0.03193284,-0.08144468,0.10286923,0.04174415,-0.09397876,-0.0074605606,0.08103062,-0.009328715,0.020745797,-0.023117948,-0.07241353,-0.0509882,-0.032503285,-0.038737904,0.08500505,-0.012557714,0.02561373,0.13994016,-0.050422676,-0.059703317,0.08474989,0.034613565,0.00028155048,0.0072794748,-0.016591778,-0.04573337,-0.06488206,-0.012430263,-0.037957303,0.025342816,0.076504976,-0.042706408,-0.012392769,-0.07633492,0.002408506,-0.034162782,0.0145621495,0.026740033,-0.0061912215,0.035815194,-0.04660443,0.009298916,0.08301995,-0.030256217,-0.020174693,-0.008196279,0.05308059,-0.033257212,-0.004684528,-0.057192147,0.043283194,-0.046138726,-0.016771406,-0.057899874,-0.021062285,0.022747412,-0.044040386,0.016759213,-0.03242719,-0.02624462,0.060654707,-0.046111457,0.019651113,0.015358231,0.01726632,0.022036973,0.046810757,0.0057679377,-0.044778824,0.029898133,0.06469367,0.018341133,0.018197471,-0.007719159,-0.060821023,-0.061328053,-0.022975497,0.048336767,-0.023146782,0.033120934,-0.027891664,-0.03561596,0.014501504,0.101591356,-0.080107264,-0.08499316,-0.039890245,0.059466094,-0.017288096,-0.0034509492,-0.030267708,0.024339516,0.009459012,0.040265866,0.040911846,-0.0075735534,-0.03375906,0.08330174,0.0332766,-0.035691198,-0.0630004,-0.006008336,0.007095977,-0.030117616,0.07374374,0.044171058,-0.0037776956,0.04121864,-0.041837115,7.1393104e-35,0.083469816,0.010947749,-0.015795505,-0.04365314,0.054391168,-0.02218979,-0.03583311,0.052332725,0.010041395,-0.042350426,-0.10834668,-0.08502395,0.036002636,-0.06508032,-0.07180506,-0.0013939783,-0.025373984,-0.03019752,0.06670404,0.040061697,-0.06572841,-0.025233582,-0.08654347,0.017949887,-0.003124049,0.033871576,0.020316634,0.013581788,0.07896082,0.0075513134,-0.037662935,-0.040669248,-0.092141636,0.023806535,0.024789372,0.0014477866,-0.073836595,-0.002527547,0.006132309,0.0815708,0.057001356,0.014438177,0.07344958,-0.0039215046,0.017698016,0.0076022954,-0.030102825,0.08080476,0.049770743,0.077759705,0.023123473,-0.034656275,0.12431639,-0.040115785,-0.044927984,-0.042068664,0.00045584165,-0.027444415,0.010828854,0.09633893,0.006705552,-0.0048511242,-0.0050886055,0.036780987,0.004032853,0.03896069,-0.13448961,-0.04444144,-0.0009264795,0.08527417,0.0045419917,-0.060966667,0.039883103,0.025981313,-0.00806872,-0.037498325,-0.030817637,0.028503396,0.037716206,-0.0032327212,-0.0122042345,-0.028644862,0.0058697276,-0.037321467,-0.026896529,-0.03385109,-0.031026443,-0.07673675,-0.027031593,0.014106342,0.06206439,-0.059909455,-0.021080589,0.06502845,0.053392485,-2.0050304e-33,0.073489055,-0.07994898,0.057254504,-0.10017214,-0.056169108,0.053486597,-0.03878541,0.010684254,0.013165618,0.00828689,0.06564666,-0.04608283,-0.004413953,-0.016157452,0.030057939,0.020313475,0.01915168,0.06859844,-0.04032305,0.0100729065,0.008723259,0.103734106,0.054223295,0.02820338,0.08172913,-0.04057961,-0.011452655,0.058498446,0.04232081,0.07075028,0.008661134,-0.050313912,-0.036742005,0.021967033,-0.01637808,0.07401756,-0.018795433,-0.018485097,0.026140256,0.06520983,0.01513465,0.047160488,0.014965209,0.120391555,0.032824904,0.085851155,-0.09795997,0.026124956,-0.051761657,-0.12299821,0.00024236468,-0.059262477,-0.0025693087,0.025658585,-0.0056575076,0.11008066,0.012234818,0.046425126,-0.08170844,-0.04734139,-0.04710517,-0.08678653,-0.05976682,-0.012226882,0.01810505,0.05494897,-0.021651026,0.046237037,0.03177572,0.01196391,-0.016401637,0.005697952,-0.008893088,0.07919619,-0.086951554,-0.049430337,-0.06746182,-0.02595315,-0.000870559,-0.060860977,-0.018182753,-0.011897159,-0.04482915,-0.06599308,-0.026732778,-0.07996194,0.06184697,0.10748433,-0.008831954,0.049256794,-0.06547948,0.036581457,-0.08178934,0.096471734,0.06768405,-4.2861984e-08,0.039420173,-0.11787098,0.04759811,-0.085916206,0.021925846,0.0131921675,0.03636904,0.052573062,0.07641556,-0.04154619,-0.08277497,0.07587943,-0.02050067,0.02710067,0.038013704,-0.009494827,-0.026417041,0.05989267,-0.0108156055,-0.006208094,-0.0319652,-0.030245462,-0.07874672,0.018993244,-0.023120288,-0.01589765,0.075324856,0.108252056,-0.011757873,-0.03081933,0.034329608,0.0020517951,-0.05555677,-0.013233248,-0.10135576,0.0054068095,-0.03257865,-0.04567805,0.008631594,0.010106605,-0.0027161376,-0.0070080007,-0.08874645,0.056022987,0.014333834,-0.020251505,-0.0006534741,0.04498826,0.01896779,0.020782957,-0.006173507,-0.030221477,0.0037705798,-0.053543426,-0.0437137,-0.035115827,0.0016535119,-0.047326148,-0.01160736,-0.019026097,-0.010928335,0.03763937,0.18226832,-0.05035569 +3.2.2.10,"Also acts on dUMP, dTMP and dCMP.",384,1.0,-0.05004716,-0.069427595,-0.042150103,-0.05012482,0.08504952,-0.084135786,-0.068445876,-0.011937989,0.015519104,0.053445365,0.04920575,0.02314512,-0.058328904,-0.0069719185,0.0033615646,-0.033047516,0.0031799579,-0.008794503,0.053542107,0.004207186,-0.038547125,-0.0642727,-0.04445936,-0.05912909,0.001734464,0.008611563,-0.03547448,-0.0014358315,-0.009186665,-0.05707299,-0.019953007,-0.028870832,0.019283362,0.04594805,0.04087776,0.04896363,0.022477204,0.010224783,-0.10169516,-0.03352673,0.03768836,-0.015373632,0.02777421,0.03662152,-0.043930124,-0.032918524,0.031078514,-0.028648507,0.00697995,0.0044178613,0.0020935237,0.10898395,-0.013551213,0.076309,0.01908882,-0.011756652,0.018696371,0.03357093,-0.028540822,0.06673072,-0.041853353,0.06351166,-0.084322445,0.028573463,0.09071267,0.023982922,0.032572914,0.029143551,0.026557965,-0.1335511,-0.08789416,0.015527487,-0.06709256,0.00347297,-2.6756727e-05,0.06305339,-0.011096217,-0.06420696,-0.028170925,-0.14636217,0.002216681,0.022506977,-0.04042116,-0.040470418,0.0014747097,0.047046565,-0.042652577,-0.023700476,0.06887122,-0.034915343,-0.034780722,0.032737415,-0.023971021,0.09196025,-0.03857185,-0.0041780053,0.093408234,0.045372043,-0.00035555984,0.004882372,-0.027010044,0.0057735187,0.003243664,-0.01209161,0.02651118,-0.0829254,0.051428676,0.018968003,-0.03550269,-0.047329355,-0.021424307,0.07442535,-0.011859304,0.013190776,0.11865569,-0.0066097975,-0.076490164,0.004039039,-0.14512119,-0.0017124682,-0.06344787,-0.01552328,-0.017925087,0.025177293,0.017797474,-0.0073643555,0.07620428,-1.073168e-33,0.030733593,-0.031567633,0.024126735,0.05417859,-0.039370626,-0.0061986353,0.007351239,0.03063028,0.027668452,0.046820298,-0.021680346,0.00456135,-0.010238075,0.09295778,0.03674746,-0.05896415,0.011642103,0.03859567,-0.0008539178,-0.001885806,0.058674943,0.059043325,-0.0755118,-0.006876512,0.07259407,0.091653496,0.015571545,0.07000555,0.068856195,0.028368909,-0.015615388,-0.02258081,-0.031146068,0.032744087,0.015342163,0.046171796,-0.15714468,0.054697156,-0.06549695,-0.018079713,-0.026662739,-0.021208927,-0.13302343,-0.039754428,-0.030352838,-0.097646385,-0.042981334,-0.09814326,0.010361608,0.045374088,0.05654673,0.022287833,0.05488811,0.042121865,0.025787413,-0.031144762,0.038556,-0.056847606,0.07702123,0.11770935,0.01713592,0.07349974,-0.050218895,-0.09517701,0.009276342,-0.02350856,0.05921249,0.016810017,-0.0069715953,0.08067484,-0.027437033,0.029101506,0.075156175,0.0026628613,-0.023343429,0.04608636,-0.03583985,-0.0330698,-0.07175707,-0.014403365,-0.061652806,-0.0638042,0.047820106,-0.11375378,0.02464505,-0.05117276,-0.06796932,-0.021972682,-0.06664514,-0.03777246,0.0181984,0.038710907,0.026750283,0.011954682,-0.04983713,-8.026907e-35,-0.07662092,-0.07002696,-0.08231588,0.01227003,-0.056801923,0.001253545,-0.04733747,-0.011958099,0.011867377,0.02485206,-0.06422404,-0.023775803,-0.023317806,0.0024196587,0.118446074,0.016129576,-0.006608704,-0.05497334,-0.042895626,0.03484021,-0.035398047,0.09988436,0.031597357,-0.0053448207,-0.041627746,0.049018443,-0.03321837,0.12072367,0.03364925,0.00893326,0.07154192,0.056750514,-0.069829635,0.035355214,0.07353851,0.019102491,0.016117672,0.038774494,-0.005214243,-0.024277886,0.08535988,0.020979628,-0.010500164,0.0639806,-0.007076687,0.06255303,-0.02900694,-0.06826998,-0.048960153,0.043403547,0.069086924,-0.10100814,0.037004746,-0.002342921,0.020042442,0.08343032,0.052208204,0.025614342,-0.009245156,-0.0021873922,0.1067448,-0.06582503,-0.12752762,-0.071667954,-0.018862987,0.025056012,0.047498886,0.028660879,-0.029316686,0.018894928,0.097636074,0.044783987,0.008271382,-0.07223118,-0.07863249,-0.034316704,-0.022699028,-0.020902738,0.0026306105,-0.025574533,-0.053475127,0.026098426,0.04673808,0.023146303,0.00335028,-0.007965508,-0.13060293,-0.009443404,0.02616892,-0.018571522,-0.050842263,0.021092976,-0.00418675,0.1041494,-0.008234148,-1.5769205e-08,0.035176538,0.03180802,0.03697668,0.09181009,0.02773024,0.018961415,0.015456425,0.05858468,0.07795515,0.019361155,0.06429628,-0.04344247,-0.03445297,-0.010464541,0.09112149,-0.083796546,0.00900789,0.014917691,-0.05842966,-0.0818079,0.01163649,-0.006006425,-0.019770699,0.075206675,0.014865936,-0.03913107,0.09387628,0.05301486,-0.00023769774,-0.038016032,-0.0074644634,-0.0030465007,-0.025885899,-0.040399358,0.02519746,0.12319418,0.08969045,-0.0012622727,0.022136133,0.011649344,-0.003790821,-0.008090812,-0.055322576,-0.020024253,-0.0403523,0.014875152,-0.058669783,-0.010786876,0.045944244,-0.01574199,-0.053685024,0.034051064,-0.0584627,0.033531517,0.044773232,-0.03266306,-0.066895396,-0.04016334,0.10149236,0.08331054,0.005446288,0.06352826,0.0061860164,0.010333351 +3.2.2.14,"The enzyme is thought to participate in an NAD+-salvage pathway. In eukaryotic organisms this activity has been attributed to EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.",384,1.0,-0.046776593,0.011791304,-0.01845579,-0.022158928,0.030198237,0.045738794,-0.08891542,-0.014278031,0.036567803,0.051001616,-0.007728146,0.0104055405,-0.06740196,0.08037029,-0.028392177,0.033942927,-0.080685616,-0.007682991,0.0324664,-0.014469724,0.03767158,0.08527695,0.01845259,0.016935878,0.050465476,-0.05246591,0.015476461,0.010592627,-0.052676033,-0.02213386,-0.042065535,-0.019486932,0.07604495,-0.050447717,0.03898923,0.11254502,-0.07251792,-0.074399896,-0.04333739,0.039422065,0.028166652,-0.0019669447,-0.0546451,-0.03650695,0.0122334175,-0.019246176,0.0071872524,0.031886335,0.06077854,-0.019129872,-0.017117875,-0.018707702,-0.005865728,-0.05046101,-0.002169281,0.0472752,-0.0225834,-0.04866419,-0.01747132,-0.0871226,0.014424737,-0.04053108,-0.032769855,0.048919417,0.055846184,-0.055670343,0.08585488,-0.044977166,-0.0244409,-0.020150429,-0.1060125,-0.078263834,-0.03626293,0.047859296,-0.01660788,0.020594675,-0.038989615,-0.07097069,0.04258795,-0.032557588,0.057031017,-0.013647027,-0.054443527,0.04563772,0.04120383,0.013899085,0.01133252,-0.007580296,0.005440958,0.0018454437,0.0019294178,-0.024715008,-0.0014175645,0.049828928,-0.09680242,0.02393084,0.048156336,0.06786854,0.044144563,-0.05764699,0.029198362,0.15605739,-0.004565399,-0.08825759,0.008858572,0.042376462,-0.014893108,0.13900442,-0.004705519,0.036495928,-0.02167247,-0.02735238,-0.019008193,-0.066899665,0.044556707,0.13276614,-0.0675774,-0.0808178,-0.00499653,-0.023394248,0.028881235,-0.03164086,0.019101605,0.06323733,0.024053767,0.09523814,-0.11063218,-1.000076e-33,0.07947554,0.0061050174,0.025619965,0.005840438,0.020971451,0.02821243,-0.0982191,0.010348277,-0.02495886,-0.06506936,-0.0942009,-0.046457313,0.08185476,-0.026594874,-0.035247087,-0.019029025,-0.034245614,-0.032952685,-0.0028064607,0.052881327,0.0045675193,0.028990764,-0.03275197,0.05435439,0.004201831,0.034142014,-0.012761233,0.00028474053,0.0330674,-0.0026945248,0.013004597,-0.11097547,-0.13743982,-0.010249843,0.03690639,-0.013214259,-0.017259285,-0.06107587,0.028021818,0.06577452,-0.05582197,0.014022034,0.06648898,-0.08879955,0.06494747,-0.06193437,-0.032025676,0.09575105,-0.0070494968,0.05002876,0.105175585,-0.06669906,0.11492679,-0.04878845,-0.045025807,0.06312083,-0.077450395,-0.0051113744,0.0027365691,0.07515866,0.034914166,0.038076084,-0.032302774,0.09942239,-0.07605874,0.06598082,-0.05386944,-0.09414272,0.021286173,0.04252981,-0.05635114,-0.011337058,0.109007135,-0.015485694,0.02853078,-0.030291017,-0.013720414,-0.02065565,-0.0064515816,0.06639506,-0.042540308,-0.09277523,-0.028781082,0.026694184,0.05309178,0.017080843,0.017285962,-0.040706884,0.020279055,0.07134519,0.060708817,-0.043748174,-0.050210785,0.02869461,0.015841404,-2.3963982e-33,0.14412089,-0.06963744,0.035002664,-0.119983785,-0.03510526,0.067936726,-0.012667603,-0.083208494,-0.0032194399,-0.10140867,0.057029966,0.02996919,0.06931254,-0.041957445,0.010028789,-0.046280783,-0.03129066,0.078607835,-0.02475283,0.05003038,0.04630746,0.04465286,0.022342158,-0.018219627,0.066496804,-0.054812424,-0.03208045,0.052963942,0.042568054,0.00591714,-0.034314986,-0.008366565,-0.05417609,-0.021046389,0.041896474,0.066859536,-0.06216878,-0.02396824,0.039130237,0.04018555,-0.026760409,0.045670103,-0.053957213,0.058285497,0.08093025,0.09871335,-0.033703435,0.00033521457,-0.0065331226,-0.055624105,0.040157113,-0.009468083,0.006843676,0.034694515,0.021815756,0.06835133,0.01527275,0.06296576,0.05746224,0.010870166,-0.033727698,0.018732795,0.033310156,0.013047918,0.015951583,0.047312416,-0.0077576656,0.03022056,-0.03492022,-0.016230453,0.052168675,0.025008604,-0.06493587,0.0112562645,0.0023375722,-0.013403345,-0.15649776,0.00048125134,-0.038305484,-0.022695364,-0.021966727,0.00591741,0.008038534,-0.008101005,-0.03847113,-0.10933659,-0.0006033296,0.053180527,-0.043765847,-0.01351966,-0.028058972,-0.024163455,-0.06498671,0.03893479,-0.00386316,-3.4035942e-08,0.0352434,0.06603866,0.0040609348,-0.103128485,0.0768899,-0.0081014745,0.031513028,0.019700687,0.03947795,-0.027929457,0.006166323,0.10046265,0.0070304945,0.014094535,0.034564875,-0.021833198,-0.03767366,-0.0021951818,-0.025013244,0.0030471773,-0.014713111,-0.012112428,-0.094797015,0.087836735,-0.03252523,-0.043505423,0.027235458,0.013370344,0.08838875,-0.08505618,-0.0004982449,0.022247363,0.057177544,-0.024527993,-0.07813336,0.027185049,-0.03128858,-0.026904555,-0.030919503,0.027077857,-0.05198566,-0.10879595,-0.028196843,-0.035051785,-0.006511973,0.018641999,0.015205909,-0.013880008,-0.048740264,-0.021576347,0.024590733,-0.0015568399,-0.0029096426,-0.063132755,-0.030079229,0.0036068414,-0.012704917,-0.13770513,-0.006840814,-0.026919572,0.009286215,0.021327917,0.11862377,-0.05925364 +3.2.2.16,"Unlike EC 3.2.2.9, adenosylhomocysteine nucleosidase, this plant enzyme has little or no activity with S-adenosyl-L-homocysteine. ",384,1.0,0.025221812,-0.042634103,-0.06635824,-0.030963069,0.097124554,0.09105564,-0.13593343,-0.018962208,0.04978321,0.036447838,0.11018846,-0.015502332,-0.04360668,0.018480187,0.0015201358,0.077421285,-0.066769265,-0.0009484551,-0.021460231,-0.07572751,-0.03749693,0.04236802,-0.011004386,0.09027146,0.054869123,-0.041902557,-0.0036690563,-0.0009822979,-0.09522442,-0.048772383,-0.06673652,-0.063420705,0.06662908,0.01301418,0.106051065,0.09043387,-0.043338705,-0.059015073,-0.012473184,0.028139194,0.011032349,-0.03826403,-0.008413496,0.00946188,-0.075782076,0.02308498,-0.015649319,-0.027211476,0.029745895,-0.038071476,0.04611188,-0.11462988,-0.042128775,-0.07685736,0.01898476,0.017637284,-0.08134162,0.06515151,-0.0012892087,0.022618044,0.09101504,-0.023426957,0.039486993,-0.0017248983,0.079293996,-0.034415655,0.024604952,-0.0699744,-0.008145726,-0.0025370736,-0.008191727,-0.09173302,-0.030317096,0.0862379,-0.04582431,0.018579753,-0.05361908,-0.033815943,0.037617993,-0.016687281,-0.005918589,-0.059407476,-0.023317136,0.02579945,0.026447972,-0.011773729,-0.0027603616,0.04617099,-0.010596877,0.004699245,0.033688687,0.0010926513,-0.009718578,-0.05998441,0.01853451,0.021261536,0.04042969,0.0012939569,-0.11690187,-0.03480017,0.04705278,0.07645566,-0.07614766,-0.05714523,0.026576303,0.08964751,-0.043398533,-0.025633337,-0.07916902,0.02845631,-0.005843135,0.025014063,-0.007709613,-0.039732862,-0.062676296,0.0051629557,0.029549882,-0.044649106,-0.085739754,0.079283856,-0.012186281,-0.032316018,0.0706729,0.07794978,-0.033596437,0.039826956,-0.025023945,1.6286246e-33,0.06672582,0.018008303,-0.0067330543,-0.016823487,0.015095238,-0.037888944,-0.011264954,0.08847358,-0.02173349,-0.044277158,-0.12644333,-0.03424375,0.06739765,-0.06304835,-0.009118577,-0.030888204,-0.0115256095,-0.045078285,0.04912787,0.044321004,-0.023099147,-0.023578817,-0.036367033,0.0591473,0.053003743,-0.03989265,0.016915236,-0.014242013,0.078154296,-0.008831184,-0.07521383,-0.04338808,-0.06462956,0.009508296,0.0032040838,0.00045813012,-0.047968157,-0.05614577,-0.0011911487,0.028775902,-0.020140203,0.03974033,0.055899654,-0.13281772,0.009409314,0.030129746,0.028764732,0.02970436,-0.04904794,0.054448526,0.054267835,-0.023600746,0.041876715,0.007005863,0.0031910315,-0.04473809,0.030036142,0.019231038,-0.010992601,0.035974663,0.017126285,0.051751472,-0.035201766,-0.051295742,-0.021936638,0.041907478,-0.179206,-0.06813141,0.014025976,0.025417916,0.03736423,-0.027351597,0.05777612,0.031533442,0.04040881,-0.01672954,-0.042850945,0.024330402,0.009060871,0.009647509,0.027179746,-0.042509552,0.0548318,-0.004771863,-0.01836193,-0.039175287,-0.002846916,0.049171552,-0.069353305,-0.0015136397,0.058792666,-0.020441152,0.015084493,0.028378166,0.07021521,-3.2528287e-33,0.037273306,-0.051043447,0.04102928,-0.06969326,-0.012282752,0.09902181,-0.005317298,-0.054683827,0.06282435,-0.03899538,0.12694024,-0.024783423,-0.02459372,-0.06869242,0.041886568,0.006683034,-0.071956486,0.06820842,-0.019320864,0.0685242,-0.057794787,0.048111543,0.009092112,0.053385273,0.036781315,-0.02843031,-0.050581425,0.07738756,0.026014673,0.020111954,-0.04539339,-0.0067022615,-0.060471144,0.0047610053,-0.011475268,0.05100568,-0.038469646,0.03968216,0.002495337,0.047971576,0.015373398,0.088079885,0.013583587,0.119037576,0.0387157,0.079806246,-0.06213423,0.10320784,-0.027526004,-0.065302216,-0.014190012,-0.034418967,-0.0068181595,0.043067407,0.042520694,0.10667398,0.017137542,0.027842775,-0.044614535,-0.03224724,-0.036614984,-0.067242734,-0.08694304,-0.0058153253,0.010860577,0.05415997,-0.10323927,0.0474839,0.03813671,0.03689181,0.05350235,-0.015395781,0.0019727286,-0.013631664,-0.034352046,-0.026674083,-0.022063661,-0.012178953,0.026642334,-0.059747376,-0.0058798054,0.04476236,0.019897494,-0.04960129,0.07238683,-8.1871185e-05,0.024559231,0.00152964,-0.013111224,0.05127166,-0.023508547,0.029558724,-0.020762853,0.07607046,0.059269022,-3.1036773e-08,0.06856042,-0.095026076,0.054170936,-0.13161023,0.090274364,0.008183738,0.057114452,0.061251376,0.09240972,0.009508739,-0.029614216,0.0381454,-0.0692346,0.029241204,0.07387115,0.015218644,0.027716264,0.07575395,-0.0017368473,-0.016351433,-0.112574056,-0.01663548,-0.122591324,-0.0027233507,-0.04829073,0.021040296,0.07571616,0.049767166,-0.03503201,0.010487684,0.0871414,-0.008165427,-0.022935232,-0.04402238,-0.06854231,0.019422628,0.02475209,0.00439001,-0.03129798,-0.012396717,-0.037770804,-0.018776847,-0.06011921,0.010403772,0.002945569,-0.0369609,0.06522833,-0.011780644,0.00073633745,0.014527831,0.06968889,-0.024945812,-0.07283974,-0.07121744,-0.013679882,-0.040147025,0.049747504,-0.078028515,-0.034404818,-0.08179857,0.035639536,-0.01952664,0.15576829,-0.021541514 +3.2.2.19,The enzyme will remove ADP-D-ribose from arginine residues in ADP-ribosylated proteins.,384,1.0,-0.028237635,-0.013596889,-0.038870044,-0.021535546,0.039844032,-0.020103877,0.019130636,-0.03097453,-0.0012789249,0.045065276,-0.00058293575,0.10175079,-0.07144895,0.063732944,-0.051872153,0.04841614,-0.06439027,0.0102429595,0.06545074,0.014387754,0.062495843,0.08542287,-0.061375856,-0.04116122,0.07784934,-0.07271341,0.06537014,-0.008418816,-0.04638786,-0.026074374,0.02466053,-0.07184516,0.04277434,-0.06104441,0.07297044,0.06678384,-0.0019372384,-0.020226141,0.011898074,0.001154485,0.06365647,0.061171956,-0.07007891,-0.0237292,0.0015830983,0.030398132,-0.07367475,0.097495414,0.0418319,0.025541525,-0.019209942,0.011407009,-0.047570266,-0.076661095,-0.038456835,0.076869786,-0.026191466,-0.052774347,-0.013015727,-0.006034356,-0.021994555,0.017018992,-0.035105303,0.0030465017,0.09448923,-0.04989448,0.09651199,-0.0049115936,0.062119678,0.028675864,-0.008566637,-0.030360434,-0.0755494,0.016621979,-0.004849843,-0.036922865,-0.048089255,-0.11056781,0.08795633,-0.0369386,0.006571578,-0.0033432087,0.040777724,0.038617376,-0.005627757,0.058125876,-0.02409613,-0.014969473,0.0171815,-0.02484681,0.016005438,-0.033521548,0.034087747,0.007058777,-0.009863553,-0.035057176,0.015510734,0.047933415,-0.08538725,-0.038298786,-0.029927686,0.06901263,-0.025405133,-0.09599884,-0.018888908,0.045870427,-0.001592447,0.05077958,-0.009501806,0.00473893,0.002581181,0.04485253,0.053148847,-0.0057200533,0.0046914513,0.118274726,-0.0015077424,-0.09618302,-0.025928924,-0.019922193,-0.045632955,0.0037503855,0.048694324,0.1311118,-0.01334016,0.07207695,-0.028257156,-7.5031207e-34,0.030991439,-0.016741864,0.0515758,-0.027762033,0.0068899766,0.012518077,-0.097217314,0.0043862774,0.031624254,0.03668108,-0.13235538,-0.15264857,0.084089175,0.005684849,-0.0040368354,-0.04425187,0.0003988681,0.015995618,0.03883913,0.027867494,-0.033613127,0.11355894,-0.013556656,0.065277,0.021308113,0.0038803855,-0.026756706,0.018255705,0.049976356,0.0024087462,-0.022769429,-0.053785104,-0.13172926,0.03835672,-0.022616891,0.012739186,-0.021125555,-0.04416106,0.04054281,0.05264456,0.027821576,-0.02002459,0.005982668,-0.0061377143,0.00858801,-0.035463955,-0.031326402,0.046081763,-0.06019361,0.049579818,0.092820734,-0.029278796,0.0776174,-0.057251003,-0.07902164,-0.014206891,-0.045881767,-0.058059987,0.09347118,0.027273102,0.0010489951,-0.029067468,-0.012513325,0.07594572,-0.05251202,0.035760127,-0.013519669,-0.13074988,0.0027862831,0.034716833,-0.07789807,-0.02757455,0.12135113,-0.043752205,-0.03506693,-0.016794384,-0.038979694,0.030531304,0.035276677,0.033261046,-0.035824563,-0.02882873,-0.017951792,0.0069568357,0.054031458,-0.048101295,0.03969648,-0.059589125,0.033167154,0.01074227,0.06810531,0.013951815,-0.12608495,0.07096423,0.03498042,-1.3935439e-33,0.0849995,-0.08884499,0.026844552,-0.0410146,-0.13516472,0.05193758,0.08120195,-0.0037080592,0.07796358,-0.1323728,0.0663075,-0.025327029,-0.02206599,-0.032537956,0.003328827,0.031166196,-0.03419044,0.02074338,-0.03706978,0.06041135,-0.040381882,0.008168407,-0.0026847275,0.03247731,0.02161838,-0.023192152,-0.0031004278,-0.028799772,0.03426959,0.0065354435,0.042777356,0.0085998885,-0.034106873,-0.0046378844,-0.0367209,0.08128956,-0.022290947,0.03559396,-0.027500423,-0.0146883335,-0.04809929,0.0670467,-0.04091634,0.051232383,0.018839702,0.055715185,0.0019049026,-0.039861843,-0.114198506,-0.09838449,0.053255413,-0.02586191,0.078050494,0.025636822,-0.05434599,0.03895914,0.07747582,0.03899583,-0.028790487,0.039181277,0.0045078346,0.016673228,0.02174213,0.0037966652,0.06653676,0.045536336,0.0339128,0.045824986,-0.023403952,-0.072692394,0.02719386,0.04064607,0.012465011,0.079467155,0.03113408,-0.044234626,-0.10136693,-0.008660672,0.00025343514,-0.060900673,-0.056498725,0.016820122,-0.05469045,0.029161163,-0.077297576,-0.051869065,-0.023400692,0.10096214,0.014745483,0.051327955,-0.05039393,-0.011916272,-0.0020008702,0.022542894,0.10332612,-2.2053849e-08,0.051436085,0.059604447,0.024562446,-0.09406963,-0.045405407,-0.0006877831,-0.012972319,0.0673991,0.035156395,-0.07100986,-0.000816355,0.10082637,-0.05515622,-0.004271443,0.009125914,0.008414484,-0.06917613,-0.029596036,-0.028889963,0.0016994617,-0.0446474,0.06358667,-0.11508907,0.016112724,-0.032472745,-0.037209153,0.05678005,0.036071546,0.055164125,-0.012630313,0.022913806,0.019325564,-0.011598555,-0.033342883,-0.032934174,0.056322966,0.015899364,-0.051134918,0.03293671,0.06259269,-0.07411876,-0.026489653,-0.0017114088,-0.070820406,-0.034609735,-0.0060163103,0.039948225,-0.0095644845,0.010066711,0.05451553,0.043020595,0.05476078,-0.052462656,-0.108831346,-0.077045426,-0.034233302,-0.080656484,-0.11022965,0.027326874,-0.0093348585,0.028690541,-0.018460603,0.07176575,-0.048986968 +3.2.2.20,Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA---[protein]-cysteine S-methyltransferase).,384,0.99999994,-0.034275826,0.007361068,-0.07524356,0.012285392,0.015467733,0.05111558,-0.072511084,0.058701243,0.023481496,-0.07291613,0.07421811,0.05144623,-0.0023940112,0.01669215,-0.028603703,0.012448642,-0.09346491,0.07873954,0.012909649,0.013881069,0.0475112,0.04305969,-0.05620244,0.0029585995,0.041877296,0.068831004,-0.022360181,0.031392895,-0.0015481063,-0.012895285,-0.01187387,0.005121082,0.057203073,-0.049027473,0.14300638,0.042246368,0.05570103,-0.00044960796,0.09108038,-0.0072531793,0.06667977,0.042343687,0.044195846,0.03624548,-0.012186473,0.066558115,0.024034474,0.005398327,-0.03692602,-0.060857728,0.04801035,-0.037274104,0.012554671,0.056261215,0.009958148,0.030988045,0.006339745,-0.08270188,0.0009480928,0.011270654,0.035152588,-0.023507867,-0.0015257933,-0.03756355,0.037056837,-0.06688122,0.10685169,-0.090273604,-0.0018471637,-0.031365648,-0.06994361,-0.0375259,-0.01975772,0.09787412,-0.01841415,0.008440084,-0.016243309,-0.1012002,0.011594604,0.033337176,0.015007196,-0.1178692,0.018044569,0.016751597,-0.025172986,-0.06529612,-0.025897887,0.087445326,1.2564478e-05,0.10042855,-0.034863327,0.00581957,0.074042626,-0.08011425,-0.050834227,-0.00035150172,0.039153367,0.08214179,0.058938436,-0.011239755,0.037360284,0.052293316,-0.12032717,-0.047311254,-0.032955356,0.008584076,0.014887018,0.109482236,-0.05820125,-0.046172403,-0.008253387,0.04169131,0.002970703,-0.02479958,-0.051450707,0.040026464,0.09791387,-0.011152154,-0.08367215,-0.015803335,-0.03992113,-0.06433609,0.048246853,0.052766383,-0.042928956,-0.042228144,-0.023779096,-2.8379244e-33,-0.011827998,0.057112083,-0.0072757937,0.01605411,0.03997022,-0.017629392,-0.021109475,0.016589042,-0.01832427,-0.020321462,-0.056126628,-0.08369326,0.04964384,-0.034830548,-0.057796653,0.0055809743,0.01686933,-0.03818975,-0.005542892,-0.03988043,0.030280173,0.04639403,0.013020971,-0.02660093,0.01628898,-0.006848575,-0.04460799,-0.03437906,0.006395299,-0.018824968,-0.0709623,0.0085642785,-0.11570272,0.017445737,0.13458851,0.006938011,0.059733596,-0.0272459,0.0036287599,0.10175751,0.031339016,0.03073511,0.008724874,-0.027064443,0.04239429,0.055950396,-0.04007548,-0.009610075,0.026111163,-0.0041723647,0.045164343,-0.028008886,0.01534277,-0.04500177,-0.0899705,-0.019462885,0.019952742,-0.030991776,-0.054487437,0.07853372,-0.056387555,0.027243277,-0.0345311,0.019442232,-0.0006697645,-0.0723299,-0.032278948,-0.061721273,-0.07288989,0.049147643,-0.030703677,-0.041771293,0.10141469,-0.016787324,0.00857947,0.008614639,-0.10877997,0.018373268,0.04047922,0.04775741,0.03647498,0.06802257,-0.023912815,-0.06225251,0.010650029,-0.0146384565,-0.045218512,-0.070039324,-0.005045216,0.055837035,0.07144125,-0.0672978,-0.008758541,-0.042090055,0.031742524,-1.7030727e-34,0.06157553,-0.03840481,-0.015495505,-0.10914539,-0.08278821,0.040812664,0.060896695,0.06460928,0.014492341,-0.05015883,0.042177543,-0.027831653,0.008340545,-0.024890224,-0.02757483,-0.04451969,0.011815845,0.009172982,-0.04034106,-0.030913994,0.016252622,-0.006803733,0.0052036336,0.0785669,0.061546963,0.00892316,-0.05951769,0.12367917,0.07482941,0.046841253,-0.07864431,-0.046499144,0.035366822,-0.02712826,-0.017963408,0.09173329,-0.06278529,0.08281161,0.022879677,0.017936885,-0.04016124,0.074871585,-0.089787856,0.08417852,0.031085877,0.10380713,-0.04982428,0.047287807,0.033221107,-0.055945605,-0.00013373421,-0.0050332025,-0.045999795,-0.0064140563,-0.012898149,0.00387545,0.0034155734,-0.022975506,0.035962448,-0.0015553908,0.0027443506,-0.0041497815,-0.07058683,-0.028913282,0.0095973145,0.0025563468,-0.03917921,0.015325984,0.014224618,-0.051199656,0.014521085,-0.006174476,0.018019048,0.06014585,0.023368083,-0.040379364,-0.09932697,-0.012383651,-0.01450854,-0.034840427,0.0008691239,-0.002078689,0.009455166,-0.023417596,0.079854965,-0.027317235,0.066315144,0.03546029,-0.065015994,-0.07905787,0.0067221965,-0.00875413,0.035218183,0.07569928,-0.0053713256,-3.3290682e-08,0.048409212,-0.10805561,-0.020860432,-0.08591121,-0.006742279,0.0593433,-0.02677688,0.083205774,0.102544785,-0.05338187,-0.07789001,0.048046038,-0.038791105,0.044441108,0.023953484,0.045962896,-0.02655858,0.011060119,0.034276832,-0.006791237,-0.04831224,0.0220836,-0.10736687,-0.025654327,-0.014858124,0.02896701,0.042128373,0.08437629,0.0061534783,-0.03379796,0.064726606,-0.036153346,-0.0075203264,0.046923712,-0.015510174,0.018446486,-0.031516306,-0.079398505,0.028719516,0.0009091255,0.010664658,0.08736299,-0.13088906,0.045336947,0.027777763,-0.02931633,-0.057164997,0.1199894,-0.01100288,-0.014346809,0.13265169,-0.09121518,-0.07597062,-0.055232607,-0.029694535,-0.073341794,0.032195438,-0.07297984,-0.063905306,-0.027666729,0.022309065,0.002114396,0.13563587,-0.09292769 +3.2.2.21,Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA---[protein]-cysteine S-methyltransferase).,384,0.99999994,-0.034275826,0.007361068,-0.07524356,0.012285392,0.015467733,0.05111558,-0.072511084,0.058701243,0.023481496,-0.07291613,0.07421811,0.05144623,-0.0023940112,0.01669215,-0.028603703,0.012448642,-0.09346491,0.07873954,0.012909649,0.013881069,0.0475112,0.04305969,-0.05620244,0.0029585995,0.041877296,0.068831004,-0.022360181,0.031392895,-0.0015481063,-0.012895285,-0.01187387,0.005121082,0.057203073,-0.049027473,0.14300638,0.042246368,0.05570103,-0.00044960796,0.09108038,-0.0072531793,0.06667977,0.042343687,0.044195846,0.03624548,-0.012186473,0.066558115,0.024034474,0.005398327,-0.03692602,-0.060857728,0.04801035,-0.037274104,0.012554671,0.056261215,0.009958148,0.030988045,0.006339745,-0.08270188,0.0009480928,0.011270654,0.035152588,-0.023507867,-0.0015257933,-0.03756355,0.037056837,-0.06688122,0.10685169,-0.090273604,-0.0018471637,-0.031365648,-0.06994361,-0.0375259,-0.01975772,0.09787412,-0.01841415,0.008440084,-0.016243309,-0.1012002,0.011594604,0.033337176,0.015007196,-0.1178692,0.018044569,0.016751597,-0.025172986,-0.06529612,-0.025897887,0.087445326,1.2564478e-05,0.10042855,-0.034863327,0.00581957,0.074042626,-0.08011425,-0.050834227,-0.00035150172,0.039153367,0.08214179,0.058938436,-0.011239755,0.037360284,0.052293316,-0.12032717,-0.047311254,-0.032955356,0.008584076,0.014887018,0.109482236,-0.05820125,-0.046172403,-0.008253387,0.04169131,0.002970703,-0.02479958,-0.051450707,0.040026464,0.09791387,-0.011152154,-0.08367215,-0.015803335,-0.03992113,-0.06433609,0.048246853,0.052766383,-0.042928956,-0.042228144,-0.023779096,-2.8379244e-33,-0.011827998,0.057112083,-0.0072757937,0.01605411,0.03997022,-0.017629392,-0.021109475,0.016589042,-0.01832427,-0.020321462,-0.056126628,-0.08369326,0.04964384,-0.034830548,-0.057796653,0.0055809743,0.01686933,-0.03818975,-0.005542892,-0.03988043,0.030280173,0.04639403,0.013020971,-0.02660093,0.01628898,-0.006848575,-0.04460799,-0.03437906,0.006395299,-0.018824968,-0.0709623,0.0085642785,-0.11570272,0.017445737,0.13458851,0.006938011,0.059733596,-0.0272459,0.0036287599,0.10175751,0.031339016,0.03073511,0.008724874,-0.027064443,0.04239429,0.055950396,-0.04007548,-0.009610075,0.026111163,-0.0041723647,0.045164343,-0.028008886,0.01534277,-0.04500177,-0.0899705,-0.019462885,0.019952742,-0.030991776,-0.054487437,0.07853372,-0.056387555,0.027243277,-0.0345311,0.019442232,-0.0006697645,-0.0723299,-0.032278948,-0.061721273,-0.07288989,0.049147643,-0.030703677,-0.041771293,0.10141469,-0.016787324,0.00857947,0.008614639,-0.10877997,0.018373268,0.04047922,0.04775741,0.03647498,0.06802257,-0.023912815,-0.06225251,0.010650029,-0.0146384565,-0.045218512,-0.070039324,-0.005045216,0.055837035,0.07144125,-0.0672978,-0.008758541,-0.042090055,0.031742524,-1.7030727e-34,0.06157553,-0.03840481,-0.015495505,-0.10914539,-0.08278821,0.040812664,0.060896695,0.06460928,0.014492341,-0.05015883,0.042177543,-0.027831653,0.008340545,-0.024890224,-0.02757483,-0.04451969,0.011815845,0.009172982,-0.04034106,-0.030913994,0.016252622,-0.006803733,0.0052036336,0.0785669,0.061546963,0.00892316,-0.05951769,0.12367917,0.07482941,0.046841253,-0.07864431,-0.046499144,0.035366822,-0.02712826,-0.017963408,0.09173329,-0.06278529,0.08281161,0.022879677,0.017936885,-0.04016124,0.074871585,-0.089787856,0.08417852,0.031085877,0.10380713,-0.04982428,0.047287807,0.033221107,-0.055945605,-0.00013373421,-0.0050332025,-0.045999795,-0.0064140563,-0.012898149,0.00387545,0.0034155734,-0.022975506,0.035962448,-0.0015553908,0.0027443506,-0.0041497815,-0.07058683,-0.028913282,0.0095973145,0.0025563468,-0.03917921,0.015325984,0.014224618,-0.051199656,0.014521085,-0.006174476,0.018019048,0.06014585,0.023368083,-0.040379364,-0.09932697,-0.012383651,-0.01450854,-0.034840427,0.0008691239,-0.002078689,0.009455166,-0.023417596,0.079854965,-0.027317235,0.066315144,0.03546029,-0.065015994,-0.07905787,0.0067221965,-0.00875413,0.035218183,0.07569928,-0.0053713256,-3.3290682e-08,0.048409212,-0.10805561,-0.020860432,-0.08591121,-0.006742279,0.0593433,-0.02677688,0.083205774,0.102544785,-0.05338187,-0.07789001,0.048046038,-0.038791105,0.044441108,0.023953484,0.045962896,-0.02655858,0.011060119,0.034276832,-0.006791237,-0.04831224,0.0220836,-0.10736687,-0.025654327,-0.014858124,0.02896701,0.042128373,0.08437629,0.0061534783,-0.03379796,0.064726606,-0.036153346,-0.0075203264,0.046923712,-0.015510174,0.018446486,-0.031516306,-0.079398505,0.028719516,0.0009091255,0.010664658,0.08736299,-0.13088906,0.045336947,0.027777763,-0.02931633,-0.057164997,0.1199894,-0.01100288,-0.014346809,0.13265169,-0.09121518,-0.07597062,-0.055232607,-0.029694535,-0.073341794,0.032195438,-0.07297984,-0.063905306,-0.027666729,0.022309065,0.002114396,0.13563587,-0.09292769 +3.2.2.22,Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.,384,1.0,-0.00017063752,-0.07579297,-0.06378676,0.045762993,0.0008764642,-0.004249673,-0.07958621,0.0010997445,0.055964,0.01296056,0.043626495,0.018244375,0.05276131,0.18091142,-0.0018075122,-0.032160558,-0.016938776,0.05123674,-0.0065351827,0.013697712,0.011962963,0.11853938,0.013837274,0.06612405,-0.061080642,0.0046958574,0.05447411,0.012380288,-0.017344585,-0.0814764,-0.035621896,-0.06967732,0.0056445617,-0.062449012,0.016309544,0.035905574,-0.011349819,-0.0137157785,0.11441408,-0.007030388,0.0022052403,0.036982816,0.06068696,0.0017667842,0.018685207,-0.06811086,-0.0121793235,0.0285277,0.06938944,-0.081290506,-0.03194121,-0.041729826,-0.0036404163,-0.015299676,0.12093827,-0.053385828,-0.08224398,-0.09260953,0.0022795936,-0.049464263,0.0318934,-0.06807294,0.041920736,0.0074275895,0.007241106,-0.0565894,0.008994531,0.06324904,0.050282173,0.03846985,0.030468214,-0.04637267,-0.046712045,0.060348656,0.040032152,0.022231543,0.016613243,-0.0020880527,-0.06423725,-0.015394076,-0.0036253117,-0.07023598,0.055270787,-0.008966333,-0.0440175,0.032239392,0.08923426,0.019077914,-0.029390011,0.036449067,0.090855785,0.07858561,0.06704844,-0.058260504,-0.044879384,-0.110926904,-0.02095225,0.032913566,-0.052426104,-0.031611122,-0.01674063,-0.004054693,-0.09357308,0.047010206,0.021569949,-0.024468593,-0.07691762,0.03429796,-0.03348357,-0.02295925,0.09452235,0.009704743,-0.01397226,0.047898017,-0.048305616,0.021115396,0.05133149,0.015521992,0.0008289654,0.044351872,-0.025654191,-0.022281833,0.03443834,0.0261255,-0.04658683,-0.02729382,-0.04394879,3.8091138e-33,0.02327442,-0.045600403,-0.030784871,-0.012646928,0.028822301,-0.05265643,-0.058287114,-0.044628385,0.04570836,-0.011094257,-0.08519805,0.0018877275,0.02018165,0.04499452,-0.020512544,0.039274443,-0.007932272,-0.027777808,-0.101665325,-0.032015733,0.020911373,0.085326016,0.024398152,0.009065818,0.018196229,0.01004202,0.0023593854,-0.07718402,-0.0043007154,-0.01024862,-0.03798065,-0.03391835,-0.089469425,0.13004826,0.0035952106,0.035131384,0.029563123,-0.002010881,-0.024616178,0.1010219,-0.03513426,-0.0152080925,-0.06950655,-0.048456024,0.029942485,-0.034977037,-0.023457369,0.08684734,-0.07109505,0.11408027,0.038346983,-0.019171875,0.056360997,-0.043595977,-0.042994298,-0.06716259,0.017929422,-0.017185943,0.051266506,0.05471438,0.036456723,-0.021064902,-0.043534447,0.040417287,-0.034527205,0.06599607,-0.043198172,-0.11756131,0.010790077,0.04590598,-0.021376066,0.025563717,0.061301522,-0.0020159122,-0.00723373,-0.03761803,-0.09079045,-0.0006907693,0.022361284,0.08284943,-0.07791838,0.016024243,0.030466922,-0.010846714,-0.05472932,0.083468005,0.041619755,-0.04541243,0.023507217,0.06948428,0.03778966,0.051807936,-0.034338012,0.020241532,0.0803473,-4.4236585e-33,0.11816456,-0.09540868,0.07544528,0.009080515,-0.12363868,0.0278486,-0.06915447,0.03747841,0.01984192,-0.07455878,0.045524687,0.014795119,-0.02720239,0.026489807,0.0509642,0.015692437,0.049347926,0.03665991,-0.11209128,-0.01702451,-0.07979311,0.026666347,-0.012188479,-0.012946723,0.035155807,0.021356776,0.04757196,0.037454832,0.010887347,-0.021591742,-0.031975146,0.037211377,-0.020778816,-0.058056947,-0.10938159,0.1419472,0.0046036355,0.017828563,-0.009767054,0.028824838,-0.015655749,0.088310175,-0.068918705,0.09485595,-0.0616453,0.026952807,-0.027880631,0.011362754,-0.0143788,-0.030683396,0.054881703,-0.02024753,0.054799017,-0.03272295,-0.014645173,-0.04238939,0.003981302,0.020528998,0.050161052,0.03378743,-0.003567406,-0.033819523,-0.065445945,-0.019440848,0.016670313,0.033913873,-0.0033576759,-0.01723796,0.045354802,-0.056028586,0.075383134,-0.015315127,0.040096693,0.0013687907,0.033582814,0.0180673,-0.11779167,-0.043489162,0.011068485,-0.018448925,-0.040903,0.026671696,-0.005032375,0.011885243,0.09077201,-0.015551565,-0.0007923044,0.020075815,0.04603288,-0.014483151,0.037498537,-0.046821613,0.042243667,0.056376792,0.05201344,-2.7962876e-08,0.05605751,-0.06395543,0.0035981154,-0.028783152,0.030801905,0.12884149,0.028799223,0.023803638,0.049218137,0.013862316,-0.009380273,0.057038452,-0.040040106,0.029488303,-0.05059709,0.087105066,-0.06990251,-0.024844525,-0.0045375014,-0.04013353,-0.1092604,0.008218211,-0.06572695,0.016642258,-0.018666638,0.015960325,-0.029993529,0.056729954,-0.0074049295,-0.11297386,0.009236219,-0.0577901,-0.0094938995,0.012389161,-0.09900097,0.016805405,0.08778522,0.023305863,-0.024191214,-0.0015993213,-0.05432827,-0.10288958,-0.06896513,-0.0077794213,-0.10677108,-0.035358608,-0.07149546,0.019769715,-0.06529713,-0.046957415,0.10483634,-0.011237578,0.033723917,-0.014004725,-0.07726236,-0.008545091,0.0667865,-0.05912976,-0.030961297,0.034057196,0.03567633,-0.050860878,0.071261704,-0.06400498 +3.2.2.23,"May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.",384,1.0,-0.07498378,-0.008243073,0.0053244396,-0.0011818346,0.070413426,-0.00995197,0.05799828,0.09334372,0.02108443,-0.0011090077,0.097226754,0.0847823,-0.08589274,0.052023623,-0.09318084,0.021870093,-0.08933357,0.011215654,-0.06563718,0.028189234,0.035249174,0.04278536,0.0076479972,-0.002537493,-0.05218725,0.032267295,-0.024691341,-0.018828973,0.046637274,-0.077850826,-0.0041824286,0.009660041,-0.008179089,0.031689357,-0.07363376,0.07706439,0.017650474,-0.019799044,-0.0071465066,0.04070775,0.024660725,0.016237423,-0.04899201,0.06225361,0.05854594,0.0064171846,-0.031604752,-0.05730265,-0.043181572,0.05421916,0.006872726,-0.024540903,-0.032899976,0.050856095,0.071391106,-0.004851547,-0.026895126,-0.032888133,-0.02782834,0.051909775,0.009137462,-0.016293881,0.003623814,-0.04825596,0.05770881,-0.030020475,0.07738932,-0.081811436,-0.015384172,0.0086833695,0.026083257,-0.05400939,0.00871288,0.017676342,-0.09264019,0.10509161,-0.05316285,-0.071680814,-0.05494878,0.06461897,0.06058124,-0.0026779287,0.04750523,0.054366652,0.05169284,-0.016062979,-0.06344245,0.023004672,0.020627867,0.06734698,0.021197757,0.07485571,0.050905336,0.0046464447,-0.04107583,0.04872844,0.027580682,-0.043248173,0.0074602505,0.013925431,-0.02101774,-0.008644176,0.008461494,-0.06889481,-0.030402381,-0.014297149,0.01198452,-0.045790277,0.0022340869,-0.045639094,-0.06531666,0.0699562,0.00580355,0.059289694,-0.019034889,0.055553954,0.04050694,-0.004457121,-0.09979324,-0.0005515789,-0.03194615,-0.018784365,-0.0041169557,0.031116402,-0.055020455,-0.06267618,0.005377382,1.2788176e-33,0.0012235855,-0.0054137814,-0.03817042,0.04445962,0.062139962,0.010716216,-0.09371398,-0.02974998,0.0032104908,0.0061206757,-0.033584375,-0.09171971,0.03020065,0.032101866,-0.06878415,0.0341667,-0.05116364,-0.023842914,0.051355485,-0.10434011,0.051799867,-0.0466322,-0.027862677,-0.00026186465,0.011677802,0.07568793,-0.041215852,-0.012731436,0.048753336,-0.046569698,-0.02597921,-0.06430542,-0.060723234,0.018816551,0.010632171,0.028827852,-0.0749509,-0.048086375,-0.0038652418,0.056476172,0.0026233157,-0.022878636,-0.036354747,0.044275366,0.060921945,-0.046016242,-0.02451839,0.096729204,0.012835295,0.023931565,-0.00533665,-0.094164215,-0.0023572766,0.014710212,-0.08771447,0.022023577,-0.05487725,-0.06820728,0.029705498,0.011840283,0.07050057,0.011376684,-0.015207286,-0.0140578495,0.038964383,0.020922124,-0.06468927,-0.08090095,0.011870879,0.021713335,-0.011301718,-0.13557355,0.02181554,-0.0030972403,-0.003861885,0.0033065923,-0.10276757,0.023987468,0.039162803,0.06543767,-0.007626676,-0.023146074,-0.05716284,-0.016820803,-0.061748087,0.048616104,0.019617591,-0.067403555,0.027413774,-0.0031868054,0.12448883,-0.06820132,-0.048854947,-0.09093936,0.028538313,-1.4872931e-33,0.035617065,-0.09114777,0.0009760638,-0.033510335,0.039388508,-0.024945574,0.0033500975,-0.026715733,-0.010091827,-0.019387912,0.02142103,0.010615987,0.015715927,-0.013700263,0.03956428,-0.022555461,0.033334583,0.051075257,0.0038307533,-0.063389085,-0.0028729062,0.04194908,-0.06694069,0.02018935,0.0337,0.07989338,-0.048373535,-0.018694924,0.0645093,0.06416513,-0.059599433,-0.03883569,-0.05527297,0.035331823,0.08712711,0.0521242,-0.003880173,0.096056804,-0.023841692,-0.09085457,-0.019508975,0.002359727,0.010842177,0.10784419,0.05611943,0.15214872,-0.041774206,0.03238215,0.028815791,-0.037890725,0.079428025,0.09740672,-0.072682284,-0.032218814,0.035429083,0.035109196,0.009669,-0.17568827,-0.024776759,0.019232541,0.001229913,-0.05561085,-0.031609215,-0.03278441,-0.011112733,0.03950423,-0.006167448,0.119008414,0.054605614,-0.080326274,0.050197784,0.052381717,0.018620135,-0.01806584,-0.06580717,-0.025760535,-0.06393166,0.0049961917,0.009831317,-0.057824865,-0.016755763,-0.021223912,-0.03178037,-0.040452115,0.025743755,-0.062463928,0.017884426,0.0909912,0.016652985,-0.030742114,-0.021300517,-0.060464613,-0.049935777,0.10219288,0.010645188,-3.262672e-08,-0.02751112,-0.025382696,0.06527439,-0.031644013,0.051554784,0.014641349,0.023749145,0.17090148,0.07035471,-0.025839968,-0.025254482,0.08048791,-0.003572287,0.06326595,0.06534459,0.03431672,-0.027036354,0.01813119,-0.0016998863,-0.03499114,-0.040278208,-0.044164862,-0.08510789,0.030896468,-0.013559046,0.01793003,0.064039625,0.108264476,-0.034918524,-0.064477526,0.06346774,0.0037569248,0.046941727,0.04428862,0.0027150183,0.035767104,0.025840493,-0.038460463,0.00744692,-0.07630225,-0.08724396,0.045814887,-0.066674985,0.041211173,-0.0070510404,-0.086968325,0.009011838,0.01628191,0.0250401,0.0440797,0.10444279,0.008980023,-0.0011669347,0.029236246,-0.03866855,-0.06680273,0.08726879,-0.06479766,-0.016307404,-0.0213183,0.00785868,-0.048745703,0.17809924,-0.048665147 +3.2.2.24,"The enzyme restores the activity of EC 1.18.6.1, nitrogenase, by catalysing the removal of ADP-ribose from an arginine residue of the dinitrogenase reductase component of nitrogenase. This activity occurs only when the nitrogenase product, ammonium, is not available. The combined activity of this enzyme and EC 2.4.2.37, NAD+---dinitrogen-reductase ADP-D-ribosyltransferase, controls the level of activity of nitrogenase.",384,0.99999994,-0.038586497,-0.012110075,-0.03483684,-0.037459303,0.051536832,0.046739303,-0.041641053,-0.022078026,0.0015196847,-0.038841616,-0.010694002,0.044752296,-0.08016378,0.0021189384,-0.09772073,-0.0037284184,-0.07115323,-0.020345554,0.013008067,-0.04223309,0.001520704,0.06391289,-0.022720305,-0.05315865,0.060526088,-0.07912381,0.027982429,-0.03281884,-0.058346793,-0.08221865,0.006355486,-0.025800198,0.08439007,-0.060238585,0.06993705,0.09762439,-0.021081662,-0.03593969,-0.018569246,0.07205365,0.035803117,-0.032469627,-0.046596535,-0.07777397,0.020533886,0.0018326483,-0.025858132,0.11262808,0.071516074,-0.014444587,-0.018277481,-0.045778327,0.02614395,-0.051960528,0.033024788,0.03310081,-0.04778658,-0.054459915,-0.03705494,0.008648288,0.044674754,0.018495003,-0.009349407,-0.029283639,0.09944368,-0.052530788,0.10002669,-0.06922836,0.024476616,-0.009494247,-0.06792627,-0.033333678,-0.05555446,-0.0028428407,-0.026022423,-0.032224108,-0.0665574,-0.048409164,0.10496965,-0.061921317,0.0050333138,0.0056374576,-0.039976697,0.002254212,0.0074105873,0.023884075,-0.034128,-0.01718041,0.045880377,0.04297131,-0.008167264,-0.0662899,0.041859645,0.028048702,-0.050040003,0.013354436,-0.04631435,0.12794496,0.026088335,-0.034890812,-0.0037997845,0.11421676,-0.09076512,-0.09165845,-0.07223857,0.058579873,0.023177296,0.102233164,0.02701592,0.037007596,-0.0067734597,-0.0041645034,-0.0013719688,0.0069194566,0.00080605864,0.115428485,0.003939246,-0.08645614,-0.095509924,0.00870804,0.013153452,-0.015282007,0.07425828,0.114029944,0.014873815,0.079194464,-0.06053284,9.346211e-34,0.046426307,0.018673943,0.02324618,-0.015254293,0.025613723,0.031280357,-0.12456055,0.013663387,-0.012304892,-0.03486167,-0.06178024,-0.02180381,0.0444262,-0.050627157,-0.028188122,-0.038258456,0.07354076,0.025993634,0.031952355,0.02607474,0.03482481,0.04605494,-0.07518893,0.08987965,0.0057136486,0.024074517,-0.008095133,0.008190035,0.065276824,-0.031786565,0.01067993,-0.10903924,-0.08960461,0.017920483,-0.004122722,-0.072717324,-0.005135511,0.02636607,-0.0146693885,0.057936344,0.014675145,0.097012945,0.016108215,-0.051992014,0.029700305,-0.027304502,-0.025619663,0.10869828,0.07191997,0.058027893,0.023875335,-0.050273612,0.11819731,-0.11731458,0.0021566916,0.027117299,-0.040755536,0.0013985522,0.05517096,0.015770556,0.018548226,0.025534445,0.009092046,0.014920735,-0.09101156,0.050174505,-0.014244654,-0.0877339,0.046450373,0.037831742,-0.12471084,0.045044966,0.10113909,0.017983988,0.022773003,-0.06145529,-0.05277336,-0.025793131,-0.012543977,0.014401311,-0.017231023,-0.0065488224,-0.017026873,-0.015691608,0.03506944,9.382733e-05,-0.030206865,-0.028052574,0.08132717,0.04783412,0.07616325,-0.060843106,-0.12747972,-0.00976584,0.082087316,-1.8040663e-33,0.088490345,-0.057551745,-0.004178799,-0.0715191,-0.0666881,0.037257534,0.026051862,0.02554174,0.04032812,-0.052860763,0.06665143,0.0038808866,0.06908003,-0.046333324,0.030125184,-0.0068866163,-0.016774602,0.08608392,-0.028167117,0.029811054,-0.048185244,0.034124658,-0.015055258,0.006223933,0.028338611,0.029073285,-0.022832997,0.07861861,0.08441455,-0.019867871,-0.014892787,0.015153537,-0.06600558,-0.022681413,0.012658151,0.030945532,-0.017738307,0.010213069,-0.018164653,-0.031964447,-0.009921807,0.08381551,-0.0009842874,0.07722947,0.036053702,0.082780875,-0.013801138,-0.0069770287,-0.06321166,-0.08142993,0.08520822,-0.025203709,0.010130727,0.038692642,0.031105874,0.060728654,0.079268314,0.092560984,0.002287938,0.053882897,0.020535376,-0.05701713,-0.036807124,-0.015748141,0.0063356943,0.004627554,-0.0271817,0.09494604,0.020213202,0.0141313635,0.05584742,0.016392611,0.05885219,0.026078098,-0.0029109542,-0.025195172,-0.063149355,-0.01832289,0.009146289,-0.060568035,-0.06734364,-0.010440399,-0.05285871,-0.06812347,-0.017658213,-0.008471495,0.058367256,0.09454047,-0.037722778,0.050953012,-0.06873459,-0.07309926,-0.067178294,0.017657997,-0.009047536,-3.6345075e-08,0.076119475,-0.017508926,0.04237819,-0.06615288,0.06943867,0.003541073,0.0124090165,0.054272804,0.037134703,-0.05380954,-0.00550354,0.07034471,0.016370917,-0.06859415,0.045383,-0.019777618,-0.026151886,0.0081602475,-0.053028874,0.008394162,0.028168056,0.03179948,-0.14726979,0.02248388,-0.031548347,-0.046244804,0.0745447,0.043699056,0.036566235,-0.10015378,-0.008101127,0.04046297,0.08026634,-0.023768108,-0.06505876,0.02289295,-0.004382947,0.026250485,-0.0037432162,0.021878494,-0.05372838,-0.11180904,-0.042595018,-0.032009635,-0.05489237,0.0104621295,0.039380185,-0.02074805,-0.020142175,0.025266517,-0.018253582,-0.01707219,0.0003559995,-0.06492112,-0.035349663,0.055451125,-0.013308177,-0.11637757,0.028349405,-0.0048928517,0.009788295,-0.03169536,0.06109412,-0.026859574 +3.3.1.1,"The enzyme contains one tightly bound NAD+ per subunit. This appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond [2] (for mechanism, click here), cf. EC 5.5.1.4, inositol-3-phosphate synthase.",384,1.0,-0.13221104,-0.024403857,-0.07698895,-0.017687408,0.07457212,-0.053911325,-0.07874955,0.035552774,0.065732256,0.06326748,-0.004005164,0.004727051,-0.066703826,0.028472412,-0.03995246,0.047953065,-0.052067276,0.015338535,-0.026479157,-0.07272543,0.065665066,0.027235271,0.0008154889,0.010841939,0.08819278,0.07061926,0.07128262,-0.022841174,-0.030705113,-0.079862826,-0.111394,-0.026454912,-0.0057784184,-0.049049716,0.029535621,0.14378424,-0.111908026,-0.05564336,0.042357598,-0.014682681,0.050741557,-0.01071949,-0.08056329,0.00058594526,-0.098476745,-0.05569826,-0.034975868,0.0949736,0.0840845,0.01072867,-0.05119129,-0.031677186,0.029868217,-0.060436558,-0.049993522,-0.032041326,0.01051363,0.04610547,-0.057777055,-0.028735334,0.04118368,-0.02246529,-0.01080392,0.053604357,0.05041849,-0.023627939,0.089509584,-0.0074627837,-0.054397553,-0.03318244,-0.074461155,-0.014239354,0.02954716,0.018755188,0.010712799,0.04694654,-0.04048319,-0.029517747,0.06476048,0.0075098756,0.07247371,0.035968196,-0.023407245,0.07712927,0.0485203,0.02774354,0.00174755,0.03404631,0.042726785,0.017041732,0.0112120975,-0.013644271,-0.11997748,-0.00533374,-0.08201791,0.043679874,-0.013132269,0.068400934,-0.01809281,-0.046210013,0.060136344,0.08532457,0.008432273,-0.03818494,-0.02856473,0.014561956,0.015449077,0.06847826,0.0010378226,0.013513248,-0.015941534,-0.042386666,0.075274885,-0.032123674,-0.029088654,0.12323069,-0.01677555,-0.019443972,-0.02949613,-0.032550525,0.023917336,-0.04434412,-0.019981088,0.038880177,-0.09850047,0.020266013,-0.1015867,1.2956963e-33,0.08009405,0.08240811,0.009551968,0.02539035,0.022112032,0.033444036,-0.038931902,0.023167504,-0.13277125,0.0010440927,-0.029566698,-0.072265305,0.06962766,-0.076586045,-0.014421878,-0.030585794,-0.04633821,0.016740436,0.006602309,0.039710887,0.038825467,0.035741646,-0.080452435,0.036209602,-0.051990613,0.10076279,-0.04117462,0.052828245,0.037649713,0.016788099,0.021931328,-0.07504478,-0.07941865,-0.041388214,0.05718824,-0.0726259,-0.033079337,-0.012305489,-0.02468989,0.074472494,-0.030346168,0.030626176,0.015664108,-0.032732695,-0.008360067,-0.10460618,-0.011791735,0.083242714,0.038195346,0.051974747,0.03755622,-0.053579833,0.113364995,-0.09605584,-0.03634399,0.022560894,0.014008458,-0.01733133,0.015362796,0.07104742,0.052323185,0.0076136356,-0.033560365,0.03733401,-0.046719898,0.031668022,-0.09381976,-0.03085987,0.03439471,0.11370522,-0.013407211,0.03270787,0.01591743,0.012544419,-0.0033986382,-0.002823152,-0.026383627,-0.0063336114,0.013034072,0.006284352,-0.009211488,-0.05994513,-0.022588655,0.01563675,-0.035725974,0.009713101,0.03504734,-0.033484302,-0.053159676,0.08036772,0.11415689,-0.08615465,-0.030724414,-0.022131829,0.01298558,-3.0600818e-33,0.11844169,-0.047730863,0.06531446,-0.1488831,-0.06584321,0.053041194,0.017444033,0.0042191646,0.021875063,-0.027269438,0.08108076,0.016511805,0.014199903,8.2735e-05,0.008151981,0.013649449,-0.013993383,0.012638492,0.011842649,-0.00696229,0.111176305,0.057773173,0.061155673,0.03656457,-0.020448683,-0.016767412,-0.045708526,0.012509159,0.023430273,0.09034197,-0.045286458,-0.022235839,-0.03487563,0.012288112,1.4002273e-05,0.0073247044,-0.032539606,-0.014926032,0.0175357,0.018624684,-0.01540617,0.04211818,-0.011061183,0.06823323,0.015357741,0.047207043,-0.08775825,-0.026243778,-0.004021651,-0.11008165,0.013496362,0.057378057,-0.043762777,0.056755126,0.009244929,0.010207378,-0.011517939,0.030269984,0.01911004,-0.038354393,-0.05795175,-0.054270405,0.017414665,-0.013264475,0.05582642,0.07832731,-0.03177675,0.055833627,0.04149758,-0.010696916,0.022038503,-0.021511197,-0.013875719,0.027886294,-0.004431485,-0.06011369,-0.09333785,-0.0026478516,0.010984273,-0.0054371324,-0.028516078,-0.036690615,-0.07577754,-0.06396584,-0.021192087,-0.06865234,0.07005638,0.114453316,-0.024556082,0.063526444,-0.009653538,0.068647146,-0.046489447,0.073283955,0.020733513,-4.01203e-08,-0.0006585464,-0.060417168,0.018665098,-0.040065203,0.034362536,0.089848675,0.039849084,0.010465061,0.09335304,0.044331815,-0.028201414,0.08577143,0.03968396,0.045077894,0.05303586,0.033881247,-0.0649895,0.035364922,0.0043793847,-0.06866799,-0.04304422,-0.001181891,-0.034677815,-0.005417994,0.0312126,-0.030606704,0.010840908,-0.013519927,0.0154732475,-0.023345187,-0.056173474,0.014026786,-0.004257141,-0.057219937,-0.07174437,0.07736054,-0.10000557,0.0072506424,-0.06320405,0.04664662,-0.057028707,-0.060222987,-0.04865821,0.039566703,0.027353812,0.036162402,0.03983101,0.038373113,-0.043023914,-0.039248984,-0.03188904,-0.02315561,-0.037822224,-0.047325317,-0.08962938,-0.026586026,-0.0118460255,-0.01075831,-0.019745689,-0.050565995,-0.0021216874,0.02922708,0.14237188,-0.05544329 +3.3.1.2,"Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC 3.13.1.8, S-adenosyl-L-methionine hydrolase (adenosine-forming).",384,0.99999994,-0.027029559,-0.052583616,-0.038216975,0.015384872,-0.031021744,0.038364615,-0.061652783,0.018135158,0.051329073,-0.0008605394,0.0011427989,-0.0031472435,-0.03724687,0.04939888,-0.04476324,0.016126208,-0.09859425,-0.002785191,0.026548393,-0.04136543,0.062177636,0.03843398,-0.039947525,0.07408047,0.083764106,0.051169243,0.034048997,0.06306448,-0.010782883,-0.012289975,0.00058394985,-0.06772873,0.055536967,-0.020529635,0.09861647,0.09419909,-0.027456209,0.025287377,0.025589438,-0.009955184,0.056555323,-0.05845528,0.056981195,-0.012897415,-0.03671854,-0.03534329,-0.07791053,-0.018389888,0.018092323,-0.01219518,-0.009879308,-0.08235399,-0.070220694,0.02989825,0.08669804,0.010455872,-0.076803654,0.037884247,-0.0029903874,-0.018799907,0.016619353,-0.024581457,-0.018541805,-0.017811127,0.015206924,-0.03882128,0.029264549,-0.050038252,0.06513472,0.017356558,-0.04534905,-0.025501745,0.027966388,0.04534715,-0.03971676,-0.039951928,-0.01785896,-0.034063525,0.046969466,-0.063238576,0.05871508,0.040370185,0.0002242098,0.067651555,-0.004435613,0.0064880457,-0.028533846,-0.017975971,0.08102662,-0.09212611,-0.073031664,-0.055893976,-0.043190833,-0.053835273,-0.0010821753,-0.005425782,0.041750755,0.022056535,-0.069928035,-0.02373089,0.047213018,0.03863431,-0.114531405,-0.10537363,-0.02965276,0.05582948,0.01099862,0.1186669,0.022479476,0.02212703,0.019617075,0.038868174,0.035824366,-0.024879325,-0.025232587,0.03612437,-0.00432439,-0.015884947,0.0067476667,-0.03214748,-0.025663842,-0.0457664,0.061751805,0.020528251,-0.02774417,-0.009261829,-0.018733544,2.714911e-34,0.11302916,0.034351666,0.04073921,0.018856887,-0.024049364,-0.050713737,-0.056859884,0.029830463,-0.012299849,-0.05337655,-0.052127577,-0.021464212,-0.0043638176,0.006274866,-0.056249723,-0.013007465,-0.031041974,0.033747222,0.03198139,-0.010271047,-0.0895157,0.035275035,-0.00618735,-0.006196919,0.011781748,-0.055010833,-0.004891068,-0.0075355186,0.08616331,-0.00033766302,-0.018121617,-0.00022672756,-0.064856574,0.04698825,0.0073778555,0.062214665,-0.15941292,-0.03790053,0.106275186,0.10868862,-6.9806074e-06,-0.025731958,0.04894558,-0.106469184,0.0055473833,0.03544328,-0.06857247,0.0706581,0.003128277,0.039225362,0.028298624,-0.023978587,0.06507391,-0.018900182,-0.09200194,-0.031883046,0.017122895,-0.043639082,0.03372883,0.098022334,0.0021630558,0.028015826,-0.011713085,-0.016105399,-0.070009544,0.007617194,-0.07299167,0.0066850027,-0.0005750076,0.07872548,-0.0106482655,-0.0050964705,0.064206615,0.031203412,0.020030472,-0.038961694,0.044455707,0.041820433,-0.0070380084,0.088146076,0.036360692,-0.04095522,-0.0067626163,-0.01572872,-0.07477594,0.029353173,0.012199171,-0.06781677,-0.032863565,0.06847914,-0.046808176,-0.054827437,-0.007885177,0.006772186,-0.024712348,-1.7772224e-33,0.041371305,-0.06483774,-0.009894756,-0.087788664,-0.0450457,0.013946166,0.072364114,-0.0714786,0.017701892,-0.020886777,0.12400368,0.01040078,-0.056296036,-0.09919376,0.024552466,-0.0042791013,0.009375146,0.04791683,0.05612663,0.01298778,0.039803863,0.07415666,-0.07021221,0.07797629,0.13502164,-0.048202734,-0.007244246,0.0354187,0.076608375,0.07056307,-0.009562562,-0.052450776,-0.053429708,-0.0016864687,-0.05127518,0.05143435,-0.009706252,-0.015638245,-0.018314447,-0.02268584,0.010974558,0.039869968,0.060407907,0.14624892,0.07667413,0.0730489,-0.061752416,0.013561292,-0.035694353,-0.062940605,-0.013084315,-0.08513245,-0.036364324,0.021714976,-0.028323159,0.11617455,-0.044839505,0.02009617,-0.018392654,-0.09373882,-0.06613401,-0.08365779,-0.031902675,-0.05807282,-0.026035726,0.042567417,-0.07416316,-0.004187544,0.022431426,-0.0053622746,0.018968888,-0.071163684,0.029178664,0.05041819,-0.040468875,-0.059147216,-0.06261237,-0.017278634,-0.01128654,-0.042401258,0.053373806,0.05890179,-0.0111421235,-0.0056793396,0.026042083,-0.0168876,0.07185429,0.09766042,-0.058789205,0.06715517,-0.02292678,0.034866266,-0.032065235,0.08168369,0.032746375,-3.4819628e-08,0.045099035,-0.115715414,0.053373754,-0.039190844,0.015650922,0.059267003,0.07306084,0.060418203,0.06302722,-0.024047744,-0.06953235,0.047390148,0.021834265,-0.016679712,-0.010540243,0.005647984,-0.034886,0.065048754,-0.059168335,-0.05545891,-0.09886824,-0.008977385,-0.0893291,0.047748275,-0.020885348,0.0027050348,0.046947718,0.06647668,-0.04603774,-0.010332096,0.062535234,-0.039373655,-0.0015842584,-0.047967467,0.018609159,0.027470697,-0.04080345,-0.012367331,0.00076186156,-0.06036461,0.001277072,0.01327618,0.03163212,0.086567156,0.05839072,0.0020405748,-0.03185083,0.080731995,-0.030223459,0.03330764,0.09523352,-0.010422709,0.016220717,-0.0842285,-0.033941902,-0.021117195,0.0009773795,-0.07057957,0.0013405702,-0.05162225,0.050929748,0.052519057,0.2152803,-0.00572565 +3.3.2.1,"The enzyme is involved in the biosynthesis of several siderophores, such as 2,3-dihydroxybenzoylglycine, enterobactin, bacillibactin, and vibriobactin.",384,0.99999994,-0.060869828,-0.0961989,-0.12573588,-0.04546535,-0.01059646,0.0337071,-0.07108045,0.023948682,0.02716074,0.031205488,0.015896447,-0.09000475,-0.06556319,0.010752326,-0.017916402,0.012373835,-0.057277624,0.015373685,-0.0148535995,-0.024528248,0.0025902425,0.047166295,-0.033182155,0.02045534,-0.06194722,-0.004400317,0.0745599,0.04924568,-0.013991998,-0.02558645,-0.018687522,-0.029589368,-0.023399834,-0.06274546,0.057153504,0.101404764,-0.07423892,-0.05512962,0.07798081,0.021716356,0.008664726,-0.010175634,-0.0003094489,0.014982212,-0.026137717,-0.032798707,-0.0003237275,0.020241942,0.11777281,-0.030173289,-0.074434415,0.016042326,-0.06041583,0.06144216,-0.00396581,-0.00059073296,-0.04273503,-0.029916234,-0.039376795,0.035924003,-0.025708372,-0.011774355,0.06728787,-0.008463459,-0.057791885,-0.076138504,0.0048599597,-0.034993272,-0.03414827,-0.028670285,-0.08467765,-0.08165475,-0.043148648,-0.003106397,-0.008716186,0.06196616,-0.0028332365,0.06718107,-0.0040717707,-0.10109302,0.046064973,-0.07406242,-0.013563424,0.14940833,0.0162236,-0.013822506,0.05419575,0.031533025,0.05041903,0.07928267,0.03705933,-0.04140746,0.02093237,-0.114523165,-0.023335477,-0.009535867,-0.051227298,-0.02400863,0.03714272,-0.021576464,-0.04722964,0.031241182,0.045970403,-0.080597505,-0.009632396,-0.0013887886,-0.0125390785,0.12179161,0.06444131,0.0033880377,-0.025452696,0.052732807,0.05066494,0.023230111,0.00086149306,0.07427379,0.04474196,-0.030259643,-0.025393726,0.054990668,0.04839828,-0.039289217,0.060925808,0.031252295,-0.09175505,0.019105902,-0.097962394,1.996387e-33,0.057177734,-0.00096663233,0.01879187,-0.003745726,-0.042695597,0.062347878,-0.10509462,0.027687317,-0.056493144,-0.015868556,-0.06886313,-0.077271104,0.076952934,0.042871613,-0.011077867,-0.06608904,-0.053980708,-0.038343154,0.010892078,-0.014337949,0.028897673,0.059129227,-0.07572747,0.017198412,0.008357376,0.055722233,-0.048083838,0.022567803,0.010269201,-0.012722924,0.0020834687,-0.08852714,-0.06159885,-0.064815946,0.0929504,-0.0062511126,0.018119738,-0.06850344,0.009636284,-0.026400523,-0.0011801631,-0.007989356,-0.030493652,-0.062963955,0.032417193,-0.011045186,-0.03520899,0.101399645,0.090747185,0.018484281,0.033145756,-0.021041576,0.11829078,-0.059051704,-0.049035925,0.04279266,-0.010598107,0.021248065,0.03643663,0.03235084,-0.028669327,0.04147873,-0.040051516,0.02561106,-0.017326033,-0.021419723,0.008853825,-0.047458556,-0.023666956,0.008188047,-0.08095602,0.0046629827,0.056077104,-0.047492523,-0.021882169,-0.033682015,-0.083470024,-0.049684662,0.068324834,-0.037387967,-0.009391626,0.0076694787,0.0050507495,-0.023002023,-0.028388953,-0.0055497657,-0.062978595,-0.055863656,-0.02109093,-0.03603928,0.06636166,-0.05224717,-0.05275298,0.015835209,0.02568756,-5.564163e-33,0.017022382,-0.09971049,0.02050428,-0.08455407,0.006187129,0.041662633,0.044865552,-0.011856146,0.019351047,-0.0013593367,0.029034734,-0.022804022,-0.021109404,-0.0999898,-0.004738154,0.04892383,-0.011371288,0.009144156,0.050583754,-0.04262419,-0.0037731803,0.034138855,0.08492557,0.00478636,0.023689706,0.042689662,0.017875161,0.13104215,-0.006447203,0.10352887,-0.0364514,-0.0064265323,-0.010365791,-0.03960912,-0.042826604,0.027357785,-0.05730672,0.00025196624,0.050983917,-0.046795018,0.027628206,0.033350773,0.022709476,0.06637609,-0.05703397,0.10524646,-0.08823149,0.081495054,-0.02843592,-0.06331946,-0.044227846,0.029766494,0.030360673,0.02915449,-0.0025089711,0.06615677,0.009137963,-0.044883482,0.01513386,0.05018703,-0.027014311,-0.009176034,0.07718509,0.030779475,0.009913762,0.0944361,-0.019537697,0.0016719003,0.08155096,-0.06418201,0.097264126,0.004951107,0.0032558867,0.047317553,0.021325866,0.017830895,-0.090556875,-0.08400696,-0.019694038,0.029623413,0.030928124,-0.003925,-0.045952827,-0.010178785,-0.076149926,-0.10493324,0.017419113,0.09407675,-0.009572225,0.0013888123,0.0027044974,0.022693578,0.009153148,0.07853922,0.04707049,-3.6988162e-08,0.03814005,-0.08043402,0.13228518,-0.07241229,0.026877724,-0.004848428,0.0019844733,0.05436749,0.048739213,-0.013641968,-0.018893678,0.022290293,-0.027085172,0.03215287,0.05529239,0.113837905,-0.053583972,0.0122184465,-0.017269636,0.0015846706,-0.026884602,-0.031321302,-0.05843142,-0.008667835,0.026338913,-0.053882465,-0.08375137,0.0072520208,-0.0208639,0.021231266,0.0075260196,0.015083746,0.020593474,-0.02411231,-0.11801996,0.07924182,-0.077769056,-0.05679049,-0.031288583,-0.0030064867,0.021877259,-0.018010003,-0.071652524,-0.011040508,0.039498456,0.03870016,-0.008065716,0.111470096,0.019237297,-0.039661426,-0.021221796,0.015581665,0.013316561,-0.01911125,-0.09113876,0.019562311,-0.021765983,-0.057858083,0.05208083,-0.011942379,-0.06983825,0.08613764,0.21939489,0.010017392 +3.3.2.2,"Lysoplasmalogenase is specific for the sn-2-deacylated (lyso) form of plasmalogen and catalyses hydrolytic cleavage of the vinyl ether bond, releasing a fatty aldehyde and sn-glycero-3-phosphocholine or sn-glycero-3-phosphoethanolamine.",384,0.99999994,-0.029554171,-0.0845648,-0.053917006,0.015830401,0.07458041,0.06598751,-0.06993018,0.004494241,-0.009476944,-0.011962017,0.029944723,0.0002408642,-0.06607607,0.030098723,-0.03216177,-0.0064862394,-0.10644931,-0.036171407,-0.020006422,0.034303896,0.13342987,-0.03642142,-0.02433284,0.04429103,0.09915734,-0.043576956,-0.0051890677,-0.05120082,-0.024651911,-0.018488478,0.040274974,-0.0450681,0.021441,-0.06492339,0.04833762,0.019369932,-0.045288287,-0.03245793,-0.044165034,0.0349755,0.063692614,-0.12293759,-0.05199092,-0.10544493,0.024473533,-0.009168704,0.0152494805,0.019220775,-0.045036145,0.08481118,0.021364707,-0.102730066,-0.05344101,0.012416453,-0.073880635,-0.014485084,-0.09352829,0.09767132,-0.0064349785,0.021560058,0.011605007,0.093699194,0.0052799103,0.06603736,0.058448844,-0.067753255,0.079063185,-0.0454616,0.009839753,0.010723883,-0.014676443,-0.1028851,-0.004449091,0.047076136,0.066178046,0.0049278983,-0.024013905,-0.004473454,0.034229133,-0.042210042,0.086108945,-0.0062344917,-0.027307197,0.095861115,-0.027123034,0.042773407,-0.06270064,0.014943481,0.0029793975,0.007228452,-0.00030755202,-0.06607358,-0.016905604,0.019800147,-0.0010030136,0.04598887,0.037050243,0.028469507,0.04648452,-0.007729511,0.014597315,0.03782322,-0.042172868,-0.09235762,0.055584718,0.02647782,-0.012045213,-0.04070184,0.016444234,-0.018955411,0.045081396,0.032953575,0.050150506,0.00505158,0.001786206,0.14454243,0.006770205,-0.07178508,-0.024513485,-0.049190108,0.020389544,-0.02877067,0.008480132,0.08414541,-0.048026472,0.06261159,-0.073692,4.0457434e-33,-0.014706952,0.007333741,-0.031438977,-0.008346215,0.02356699,-0.014652765,-0.03941955,0.034730535,-0.078384236,0.001351744,-0.1084344,0.040066972,0.037356187,0.057550985,-0.024185082,-0.00042038024,0.02470558,0.03785048,0.060542215,-0.042681303,0.0031026355,-0.005923081,-0.019604037,0.023073284,0.03642728,0.07203373,-0.0019820733,0.0029578502,0.06039102,-0.002431413,-0.022493465,-0.10310664,0.010413275,-0.04383015,0.003100722,-0.0059945593,-0.077410884,-0.06558619,0.00059873273,-0.0027678155,0.041160777,0.011258364,-0.061655365,-0.010087233,0.008191344,0.050407413,-0.112889156,-0.027227333,-0.04502147,-0.05428105,0.09301969,-0.032580275,0.036965456,-0.008785327,-0.07268106,0.038516816,0.027520405,-0.013554743,-0.030271728,-0.0048786965,-0.006331629,0.14949639,0.03034927,-0.044986703,-0.015901214,0.015074085,0.0198085,-0.018107451,-0.04624708,-0.08399598,-0.031464774,0.00429117,0.06963317,0.014442109,0.081767835,-0.0030269737,0.026183782,0.027247675,-0.015166334,-0.0049493755,0.047478337,0.017867105,-0.010996656,0.026112529,-0.02321313,-0.056344274,-0.028764682,-0.031335007,-0.021777686,0.014421402,-0.02078865,-0.04146179,0.014181648,0.020955045,-0.04462694,-6.200369e-33,0.05440072,-0.08814173,0.051369976,-0.06862392,0.0066892,0.07553673,0.009310185,-0.0044125584,0.022168174,0.005755068,0.071723215,-0.049537323,0.03351035,-0.046990693,0.038812913,-0.023697568,-0.028453985,0.047794417,0.008356282,-0.04496436,0.018400947,0.031131137,0.020572966,0.12897989,0.03650788,-0.0336711,0.023316188,0.07454361,-0.009963279,0.055009276,-0.045807548,-0.11344965,-0.0475772,-0.09522481,0.014617509,0.044565525,0.021242214,0.02682865,-0.029159848,-0.06756781,0.021300012,-0.040081378,0.058693387,0.020878041,0.054057725,0.049287893,-0.08975596,0.0133901015,0.01344645,-0.0038308545,0.010164968,-0.009587047,-0.023328658,0.044907067,0.02300499,0.10050436,0.003948014,0.04120949,-0.033308964,-0.05493812,-0.09214617,-0.061562475,-0.015695818,0.07088267,0.023686111,0.06672881,-0.035653237,0.0037978801,0.0017580617,-0.07798054,0.11683831,0.04345079,-0.008101807,0.059287407,-0.042642616,-0.015241572,-0.043457616,-0.11995598,0.037511293,-0.09621536,0.016651092,-0.027109955,0.053038605,-0.045974668,-0.0066579436,-0.07663969,0.048691202,0.12580933,0.003011665,-0.009370639,0.05475797,-0.044151794,-0.071232714,-0.022248322,0.08144984,-4.4466866e-08,0.021031454,-0.05250792,0.06751241,-0.07511551,-0.008073557,0.008694207,0.059477303,0.053133585,0.025702802,-0.085885465,-0.03446159,0.016595554,-0.009065677,-0.05989264,0.038968936,0.008252827,-0.04840256,0.11534338,-0.04326727,-0.014206846,0.033969134,-0.0012725035,-0.0643968,0.027427103,0.016242886,-0.05333356,0.023366405,0.069372416,0.00916629,-0.06276446,0.037520897,0.03448809,-0.020041125,0.039171375,-0.03167456,-0.028239967,-0.03541876,-0.05313889,-0.0055371993,0.0394962,-0.058216628,-0.027964488,0.020734405,-0.005511776,-0.0362375,0.0018214356,0.06932248,0.024054386,0.041533828,0.01025965,0.04684778,-0.029888505,-0.040084884,-0.09327199,-0.111367375,-0.09008715,-0.030633707,0.004157834,0.015111363,-0.0818067,0.026491815,0.019688142,0.2459024,0.043772534 +3.3.2.3,Acts on a variety of epoxides and arene oxides. Formerly EC 4.2.1.63 and EC 4.2.1.64.,384,1.0,-0.0069220494,-0.003694864,-0.0019430077,0.023914859,0.13348177,0.027956933,-0.005211541,0.066567555,0.040375423,0.015184741,0.05893437,-0.0010896368,-0.09208267,0.03247582,-0.027965944,0.08685475,-0.020300744,-0.016651608,-0.025099138,0.008902484,0.05363048,-0.037537646,0.031283323,-0.027324295,-0.009547967,0.07105502,0.019621577,0.008071303,0.053296223,-0.06281412,-0.02159801,0.0040827477,0.03508038,0.029111274,-0.059617367,-0.003930304,-0.00868643,-0.05112519,-0.026981603,-0.015214137,0.02000202,-0.007440195,0.017593086,-0.04200445,0.024852155,-0.039161433,0.09826634,-0.03249628,-0.032558635,-0.024970569,0.07336887,-0.06542459,-0.023040934,0.005412023,0.009149613,0.030649355,-0.057703752,0.021887353,0.019727021,0.07045798,0.061718542,-0.05832277,0.022868155,0.07813951,-0.04792063,0.016562385,0.05086118,-0.026289377,-0.08053997,-0.1099224,-0.043236714,-0.053841442,0.041366912,0.004160606,0.040086925,0.06586531,-0.018218935,-0.05334031,0.018064369,-0.014484502,-0.05374113,-0.036991272,-0.009623264,0.029676404,0.09551674,0.037919346,0.026763197,-0.0888654,0.030219005,0.044252776,0.0026125002,-0.01424858,-0.00047998474,0.03751929,-0.0012396857,0.0571676,0.056975994,0.0754078,0.012719843,0.009516174,-0.019896705,0.050264183,-0.10845751,-0.0646566,-0.028323717,0.038712233,0.0377198,0.051703554,-0.01051295,0.0143303545,-0.032252803,-0.114335336,0.018751794,-0.017858656,-0.032539096,-0.013651106,0.060941633,-0.013465122,-0.034015696,0.037509818,0.039579965,-0.0018207451,-0.023993134,0.007919515,-0.04929783,0.04706084,0.007506026,-1.8480744e-33,0.03772835,0.077096224,-0.024794217,-0.0074733403,0.002974948,0.039018024,-0.09568248,-0.0015899466,-0.0023604305,-0.0074623567,-0.045408305,0.03543092,0.048154224,-0.04382713,0.027142229,-0.06343756,-0.007465834,0.038982328,0.0024249947,-0.05006273,-0.00789059,0.043649476,-0.112274796,0.069293894,-0.034234654,0.05077506,-0.06284288,-0.05186862,0.031957977,-0.027428929,0.028020417,-0.013048645,-0.06909501,-0.0045119706,-0.041043792,0.06802246,-0.053714138,0.008834147,-0.0028262553,-0.03266663,0.023293773,0.05684136,-0.070893034,-0.05572946,0.058495108,-0.13690583,-0.050459433,0.15981917,0.17242464,-0.0010138552,0.014592647,-0.056519654,0.048353076,0.0030007942,0.009744738,0.027180836,-0.0085361,0.020513024,0.04974917,-0.00050101354,-0.023300387,0.08572926,-0.011912858,-0.026366405,0.019245762,0.056394365,-0.022243882,-0.028787805,-0.06735928,-0.027152011,-0.023764351,0.0043944875,0.11047899,-0.025129035,-0.03438766,-0.019637974,-0.05431838,0.032869067,0.047811475,-0.007968429,-0.0451375,-0.0067265797,0.052073117,-0.046249893,-0.005488177,-0.02571428,-0.083407454,0.014100895,0.0090880655,0.088747665,0.12775822,-0.067972794,-0.052847996,-0.048442617,0.006748546,1.157778e-33,0.008996932,-0.012324597,0.012480139,-0.013802274,0.03008739,0.06750137,-0.07825971,0.040541306,0.029400172,-0.08092467,0.0657236,-0.08728284,0.05886553,-0.041046176,0.016768944,-0.0021145216,-0.044840403,0.03840795,-0.01884365,-0.026798317,0.04076506,0.04950637,0.056004666,0.13257234,0.017495219,0.061432365,-0.0028429243,-0.0045995605,0.041882813,0.039495252,-0.076429464,-0.023816358,-0.08088041,0.058149338,0.026384192,0.009125818,-0.03575737,0.033857733,-0.026122753,-0.11076884,0.013423993,-0.012123693,0.034709733,0.07698058,-0.0010765772,0.0935015,0.00033790455,0.037211284,-0.0032139302,-0.017470837,-0.025890691,0.0064864233,-0.09922356,0.038817402,0.0009378257,0.05963831,-0.007302603,-0.053863615,-0.03399558,-0.021837,0.03770561,-0.041255977,0.045831375,-0.0059908656,-0.027555112,0.009995941,-0.058063183,0.112318635,0.032378796,-0.01341356,0.085500315,-0.017941631,0.010432309,-0.098592095,-0.040021915,-0.07168406,-0.022048634,-0.10284449,-0.052944552,-0.06567502,-0.011787861,0.06317501,-0.02420836,-0.006741384,0.01394249,-0.027351895,-0.008721968,0.112833075,0.03712556,0.011061868,-0.039414573,0.050176933,-0.008649449,0.061205253,0.03508132,-3.287455e-08,0.013085857,-0.0033449598,0.117975645,-0.05573735,-0.00083627866,0.009191,0.033214837,0.05081112,-0.018281607,-0.0793078,0.075249664,0.06658331,0.012494877,-0.060843,0.15965831,-0.017603237,-0.073766224,0.039795015,-0.06312171,-0.048440203,-0.09616035,-0.07278872,0.021001823,-0.0033955579,-0.034228425,-0.020915534,0.058763023,0.044527758,-0.06895146,-0.0078783855,-0.004954971,0.018549087,0.0018945901,0.036058567,-0.041160546,0.06951426,0.09343828,0.013836093,-0.10183789,-0.008911653,-0.06617547,-0.121824704,-0.044772338,0.0535629,-0.037874606,0.06060496,0.014743413,0.026854195,-0.023870887,-0.044947684,-0.029520767,-0.06776145,-0.0072194207,-0.043428622,-0.12323722,0.01762847,-0.0014649967,0.002180927,0.051405147,-0.06687299,-0.00086927746,-0.020561233,0.14985603,0.017433252 +3.3.2.4,Acts on both optical isomers of the substrate.,384,1.0,-0.020430196,-0.07528576,0.016713627,-0.00012305552,-0.014227199,-0.03321487,0.076835625,-0.030504532,0.022836149,-0.042451214,0.13112122,-0.010982078,-0.09492467,0.06439892,0.03804275,0.031810433,-0.07608231,0.035073098,0.086788565,0.017507466,0.107762605,-0.12695678,-0.06160165,-0.050301,-0.035535358,0.011342467,0.011858151,0.028806886,0.057304904,-0.05998296,0.00068385655,-0.03720888,-0.03604357,0.052458722,-0.028326701,-0.029084668,-0.0005984865,-0.04747888,-0.034526695,-0.049789898,0.048378635,-0.076561995,-0.04038162,-0.032059737,-0.0855885,-0.013048522,0.08901366,0.017808503,-0.017091393,-0.066514276,-0.022804499,-0.03204275,-0.01781974,-0.00444576,-0.0140553145,0.10273499,0.017861344,0.06665192,0.0045242193,-0.06442643,0.016959986,-0.014942509,-0.0948281,0.051308166,0.077912115,-0.046170276,0.060210213,-0.004633868,-0.034646828,-0.023083871,-0.016619647,-0.03255354,-0.051264863,-0.055702005,0.07177655,-0.012574514,-0.07807156,0.057955906,-0.0032070256,0.01460271,-0.007973511,-0.016965862,-0.0016543219,-0.0018816666,0.010096133,-0.03188444,-0.06504712,-0.02063064,-0.056110375,-0.043925542,-0.033523165,0.008103714,-0.008845925,0.0018500861,0.016788457,-0.07412636,-0.026417311,0.023577366,0.044571538,0.020639468,0.030510746,0.0039410684,-0.10393818,0.037796106,-0.044289347,-0.042656034,-0.014419076,0.013796501,-0.08063447,0.022436704,-0.030170048,0.040678747,0.04617569,0.014299677,-0.052162856,0.058892306,0.022797424,0.10500477,-0.009936457,-0.057661388,-0.05961393,0.0030270512,0.01180444,0.051051777,-0.025267454,-0.037199732,0.024483008,-3.54959e-33,0.071107365,0.018741554,-0.024403127,-0.034400042,-0.04253463,-0.053425476,0.014890176,0.0067288894,-0.07000787,-0.046784595,-0.017643375,-0.005549213,-0.012788353,0.079084985,0.068024494,-0.042909,-0.003654266,0.10686543,0.037122246,0.009465075,0.009029001,0.093896694,-0.032688677,-0.0023528072,0.032470148,-0.008178301,-0.06240609,0.012941125,-0.047493234,-0.0030652354,0.04297764,0.056726266,0.0021654435,0.02311177,0.09362846,0.053322002,-0.050629955,0.09418285,-0.03447999,-0.015162455,-0.011897437,0.016548522,0.025882535,-0.033324894,0.056328516,-0.03982361,-0.060067937,0.051414523,0.022487689,-0.0052226014,0.03648739,-0.13265412,0.016827323,-0.0137780085,0.080861345,0.03693637,-0.006931064,-0.016806383,-0.033437118,-0.038805652,0.012958409,0.038309716,0.01705855,0.011816576,0.005053712,0.09063501,-0.0022519398,-0.0260125,-0.0502792,0.020392206,-0.091038115,0.108872496,0.03498063,-0.04699494,0.007493731,-0.0012435938,-0.077395394,-0.040321026,0.0736925,0.0617654,-0.1190814,-0.00962567,-0.040012855,-0.0986972,-0.16646284,0.038736437,-0.0024437692,-0.040155135,0.00891286,0.056026448,0.07133134,-0.024428846,-0.05632685,-0.004615166,0.025952442,5.2984356e-34,0.021359935,-0.091239944,0.023441195,-0.0633414,-0.07966875,0.007343201,0.06958411,0.017746456,-0.037756417,0.032177657,0.030553339,0.035524875,-0.09614253,0.046936423,-0.08965662,0.019211672,0.022798989,0.042570107,0.03623718,-0.0045470833,-0.03167636,0.08299503,0.105286926,0.09186207,0.023731844,0.0037193522,0.13028227,0.09887806,-0.037983015,0.03803743,-0.009712323,-0.07998341,0.028640352,-0.0118736895,0.022769688,0.088266864,-0.009371758,0.037923425,-0.071219,-0.07919346,0.0034209378,0.029173952,-0.023217114,0.024679827,-0.01251542,0.018378861,0.0050321436,-0.053947844,-0.124067776,-0.1402011,-0.01742073,0.022942148,0.00025774774,0.0021894614,0.058585167,0.056048892,-0.0511071,0.049954984,0.022001063,0.035171557,0.044827815,-0.0014821256,-0.003878001,-0.058035016,0.049642574,0.016817043,0.010733453,0.029313968,-0.0043438873,0.036435015,0.12514102,0.038597856,0.05175939,-0.021934591,0.017574228,-0.04601609,-0.014497093,-0.022473086,-0.104538664,0.035977222,-0.053689126,-0.0146211395,-0.014332368,0.02480343,-0.028758563,-0.045050044,0.021056889,0.0072382465,0.004381751,0.027652672,0.030430561,0.046227224,0.060603067,-0.013244011,0.058070514,-1.6565613e-08,0.086609565,-0.016419062,0.06997392,-0.059272338,-0.091501474,0.0016328188,0.03005797,-0.02312776,-0.0059893127,-0.08586243,-0.045256246,0.08147341,0.02178724,0.015320871,0.14724438,0.026369203,-0.08676246,-0.005415313,-0.045503523,-0.018579487,-0.077590324,-0.046428718,0.042979278,0.006690817,-0.039727032,0.005227631,0.0680194,0.024077334,0.022240432,0.061395925,0.06379983,0.009328318,-0.027793733,0.061368477,-0.015602909,-0.0050088456,-0.0644938,-0.024851251,0.015477667,0.022494063,-0.003997443,-0.026494086,-0.052341245,0.046283476,0.113689646,0.123132244,-0.0040322687,0.004059811,-0.034044407,0.07654352,0.011551879,0.00356909,-0.007832674,0.018856326,-0.06299606,-0.06701556,0.013794606,0.023229418,0.015885012,0.03190651,0.07818395,-0.011424194,0.09666622,0.0037876805 +3.3.2.6,"This is a bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities [4,6]. It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates [6] (see EC 3.4.11.6, aminopeptidase B). It also converts leukotriene A4 into leukotriene B4, unlike EC 3.3.2.10, soluble epoxide hydrolase, which converts leukotriene A4 into 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid [3,4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase) [5].",384,0.99999994,-0.026860218,-0.06709514,-0.03613079,-0.00084326166,0.16036776,0.08036826,0.024436481,0.06313944,0.0038302364,0.0049689463,-0.016439702,-0.051228154,0.027519783,0.01995443,-0.057643678,0.031147435,-0.045522433,0.0045688082,-0.04604308,-0.05294278,0.05563448,-0.029473228,-0.0026487214,-0.03119565,0.015839454,-0.010120256,0.05386226,-0.044897605,-0.032941047,0.004483343,-0.012159377,-0.09758174,0.017823607,-0.01547813,0.02192707,0.07226995,-0.025861764,0.0022153885,-0.04887156,-0.020264337,0.08005732,0.049998432,-0.006979183,-0.10506909,-0.047723345,-0.026756851,0.05638833,-0.06295194,-0.06854764,0.06758307,0.0063185925,-0.046546225,-0.042149656,-0.012975498,-0.0010888996,-0.0019715647,-0.077894226,-0.0042045526,0.0020741303,0.021340089,0.02492245,-0.09962734,0.049627014,0.006408775,-0.018571218,0.0134655805,0.013232222,-0.06203706,-0.040577356,-0.078054994,-0.06273662,-0.033422954,-0.0037471422,0.04602215,0.015487237,0.08305998,0.03801848,-0.06844348,-0.002184009,-0.07214939,0.012561808,0.08477319,0.029732967,0.08883303,0.10046011,0.027948346,-0.019453328,-0.0015419654,0.015218069,0.017452635,0.05797689,0.017955933,-0.056113664,1.9202922e-05,-0.01529933,0.07396303,0.020328509,-0.024432637,-0.0043978244,0.0036134236,-0.01933701,0.07015163,-0.0032968274,-0.10899223,-0.019515883,0.08275625,0.0026275371,0.08343402,-0.0032933045,0.033052787,-0.029353533,-0.051792912,0.0071858703,0.023467252,0.062638134,0.011597909,-0.009205655,-0.05217803,-0.039752893,0.0034960734,0.041517276,0.027551023,0.09124567,0.05950735,-0.02212185,0.06689123,-0.05616176,5.616972e-33,0.020474268,0.050981753,0.027610883,-0.011734281,0.031116037,0.06107614,-0.029259024,0.09505106,0.0379598,-0.017219251,-0.06323122,-0.0034676264,0.07791274,-0.0028250332,-0.0401354,-0.03493798,0.0069257934,0.006476518,0.07985166,0.0116711715,-0.024815343,0.026104728,-0.040483925,0.020884799,-0.007059124,0.013760499,-0.003507798,-0.017470991,0.035076015,-0.019791208,-0.018256802,-0.06249743,-0.10054901,-0.06497472,0.10288373,-0.033007685,0.020333935,-0.00494637,-0.012202338,0.008538482,-0.01176299,-0.039347477,-0.104712225,-0.0022339849,0.093581624,-0.13193107,-0.049820233,0.081430204,0.027088763,-0.020425705,0.06918984,5.2448486e-05,0.105135225,-0.041609287,-0.1290428,0.041224625,-0.030463753,0.022229737,0.08366517,0.051652417,-0.0034207182,0.074857816,-0.05228085,-0.022249324,0.04184499,-0.017411882,-0.063085414,-0.091191284,-0.051406626,0.022704162,0.014065758,-0.022813864,0.14076144,0.016336989,0.022885194,-0.05684025,-0.06853274,0.051231608,0.07748482,0.0014546878,-0.030844536,0.036821436,0.06867445,-0.011439715,-0.054889187,-0.040929146,0.0051505454,-0.064697154,0.0065761157,0.040776562,0.07502218,-0.038050026,-0.043530818,-0.009221987,-0.014250301,-5.0440705e-33,0.101851985,-0.055027086,0.024359768,-0.03429165,0.0052614654,0.034076028,0.0094463,-0.0015697922,0.043454718,-0.056946002,0.14137076,-0.048249222,0.08579215,-0.061181214,0.05699385,0.05332801,-0.086270645,0.12784457,0.10892703,-0.0133336885,0.051627308,0.0019296166,0.030710071,0.073581345,0.07041133,0.04750836,0.029454324,0.03497175,0.07397724,0.08256641,-0.030152285,0.022736661,-0.026848562,-0.047261693,-0.03571957,0.037570275,-0.08607131,-0.065019,-0.030178951,0.015963018,-0.021121541,-0.048418883,0.028045338,0.007173995,0.08043383,0.111885816,-0.07877816,0.07783203,0.00075442815,-0.038656205,0.05137872,0.023688676,-0.095791444,-0.019591449,0.061516773,0.05368622,0.010032384,0.008898394,0.016109075,-0.039154388,-0.0140323015,-0.0016113464,0.03198072,0.08381479,0.0059546726,0.041894857,-0.008911562,0.034139857,-0.02337857,0.010140552,0.028077919,-0.020442707,-0.018543838,-0.08126743,0.06616436,0.02028557,-0.01067963,-0.06365763,-0.04489557,-0.0033094063,-0.020418832,0.037845924,0.028675796,-0.003038579,-0.05644454,-0.058260433,-0.025193438,0.14665955,-0.009442874,0.005047958,-0.03579368,-0.054721106,-0.056825906,0.05823069,0.050559796,-5.4227268e-08,0.016218036,0.008476498,0.049211193,-0.08538659,-0.04544708,-0.088208914,0.008945931,-0.052895043,0.01295325,-0.08592333,0.03948124,0.0023163015,-0.011450119,0.02317437,0.0366925,0.01472834,-0.020924624,0.00594919,-0.008147544,0.022055319,-0.023836656,0.020138295,-0.061616793,-0.029762655,0.0052358215,-0.086650096,-0.023675987,0.032922972,-0.052940648,-0.021293174,-0.022075735,-0.003222821,-0.011396037,-0.02820666,0.024542596,0.05383464,-0.0093424525,0.0034524756,-0.061773036,0.014414759,-0.07607237,-0.08878724,-0.009408673,-0.020239305,0.0067857625,-0.024509557,-0.007910475,0.052525107,0.015310483,-0.061696794,-0.05584453,-0.051896013,-0.011773575,-0.12202225,-0.040505707,0.0027324262,-0.025597632,-0.13811463,-0.0069604637,-0.08371441,-0.02797117,0.04989346,0.1382599,-0.0032811987 +1.14.14.10,"Requires Mg2+. The enzyme from Aminobacter aminovorans (previously Chelatobacter heintzii) is part of a two component system that also includes EC 1.5.1.42 (FMN reductase), which provides reduced flavin mononucleotide for this enzyme.",384,1.0,-0.07181569,-0.042346787,-0.088420555,0.012019528,0.062077343,-0.025094656,-0.018420048,0.076318264,-0.006149768,-0.018994924,0.0148535045,-0.05981424,-0.023050284,0.024476402,0.0018057587,-0.04965863,-0.05284975,0.0020337394,-0.030574966,-0.05705217,0.023496069,0.015803196,0.027053298,-0.03879628,-0.061462928,-0.019616747,0.060956772,-0.051716805,0.0027162207,-0.0500299,0.10703384,-0.05716921,0.08665419,-0.08390852,0.028885774,0.07453539,-0.034707393,-0.09753429,-0.02383242,0.007630313,0.0315299,0.021726511,0.07996278,-0.061103467,0.028093655,-0.07312222,0.049395464,0.028552666,0.042351812,0.05072601,-0.038530257,-0.0034012108,-0.08969722,0.014105611,0.040394858,0.044486787,-0.11001484,-0.06510782,-0.06017432,-0.030711967,-0.022054844,0.027059011,-0.017510517,-0.056232054,0.07638733,0.0028760193,0.03218243,-0.13286692,0.039360117,0.0066953194,-0.02394481,-0.058320895,-0.024932737,0.04402908,-0.042527657,-0.0103619415,0.03782915,-0.0032014037,0.07009311,-0.0058045113,-0.035645053,-0.02612496,-0.010647711,0.061840672,0.029281352,-0.02786522,0.0059570833,0.033046193,0.0057352,0.082758345,0.11654171,0.044856764,0.068148084,-0.061571486,-0.019067394,0.030867565,-0.0092485575,0.090731055,-0.001073367,0.017581299,0.0017160501,0.045529716,-0.009653084,0.021691918,-0.08818494,-0.015550842,0.029801195,0.06915242,0.016695322,0.0055835447,0.055214718,-0.025698908,0.00707734,-0.0553314,-0.014989822,0.0647157,-0.010286707,-0.11013006,-0.012717884,0.032510214,0.009177777,-0.006661309,0.047335166,0.09604727,0.0053879623,0.0048110886,-0.123247236,4.071641e-33,-0.010760472,0.0035176908,0.051390376,-0.032445494,-0.030962737,0.06505863,-0.050541904,0.025391199,0.0030732066,-0.06598966,-0.11213859,-0.026799718,0.011391978,-0.0061140675,-0.014196296,-0.047422875,-0.038924012,-0.03112342,0.057052325,0.017141666,0.021200411,0.018804211,0.030160956,0.014075978,0.06577855,0.090075925,-0.016782802,-0.053561967,0.015227248,0.015791412,-0.012185065,-0.10404811,-0.086967595,0.038626887,0.04633401,-0.024341898,-0.031473685,-0.051787715,-0.024473868,0.07681538,-0.019952094,0.05717885,-0.04072768,0.009745834,0.11930343,-0.03925199,-0.03331891,0.08862852,0.04834764,0.07516943,0.07910824,-0.0030363803,0.051758233,0.0022115808,-0.038804747,0.06697455,-0.004268439,0.030251242,0.051068317,0.06824414,0.026354691,0.0691403,0.036997665,0.06930452,0.07452311,0.05175345,0.000970289,-0.069664694,0.0482125,0.039586667,-0.026434133,-0.05777923,0.08084059,0.07463058,0.035182692,-0.044010337,-0.046942864,0.00038360528,-0.0046950513,0.034437492,-0.026909608,-0.023428341,0.0032617156,-0.0017446178,-0.05258667,-0.0016375445,-0.0014782853,-0.059713665,-0.020407751,0.013313075,0.07865684,-0.09252202,-0.067227386,-0.023043618,0.045797482,-4.3837215e-33,-0.010084324,-0.0670209,-0.010489799,-0.040226463,-0.112323746,0.044115536,0.03930345,-0.113648,0.06709569,0.030299524,0.10676032,-0.019984685,0.02146677,-0.087862626,0.021907888,0.017186427,-0.049765974,0.08906048,0.023601435,0.0076550003,-0.0011029214,0.054932047,0.05337493,0.014079034,0.043507054,0.0063816216,-0.0040862244,0.08730305,0.06370813,0.015713267,-0.051750325,0.07821961,-0.062305536,-0.10604262,-0.03270052,-0.008918549,-0.043251537,0.0073347166,-0.0036171316,-0.0055760597,0.03259987,0.0565795,0.04949473,0.06717922,-0.030711932,0.06264616,-0.057523888,0.03655813,0.0025861603,-0.06406811,0.0022775086,-0.04292795,-0.043994416,-0.010200763,0.04634351,-0.0032627843,0.046009228,0.04404881,0.043989863,-0.0014253573,0.020482268,-0.07021137,0.058915924,-0.06878752,0.066818036,0.016722012,0.032330528,0.050217416,0.05038531,0.028537167,0.06380456,-0.04512745,0.14628622,0.018561294,-0.030997992,0.1131306,-0.02734515,0.017364439,0.05035439,-0.10834564,-0.0022198115,-0.02006123,0.006833396,-0.08194329,0.0052737473,-0.10658733,0.007855146,0.053996123,0.00924243,0.076770715,-0.030223925,-0.042566333,-0.00882491,0.0076795146,-0.03585614,-3.943568e-08,0.023512492,-0.07502738,-0.021884939,-0.061030455,0.09351999,0.09263691,-0.083329394,-0.07718054,0.030127233,-0.016645847,0.052329484,-0.00051406753,-0.01958568,-0.00027027834,0.024073992,0.014694736,-0.028843263,0.037876517,-0.061037168,-0.0091313515,-0.111795895,0.012878962,-0.15195762,-0.010600147,0.009029716,-0.032261796,-0.003013985,0.05314176,0.037122153,-0.036762808,0.0071406513,0.003441376,0.01308743,-0.0070538144,-0.14018978,0.012155547,-0.015672887,-0.005250768,-0.05730474,-0.062380686,-0.062275704,0.002113456,0.0009244036,-0.009325874,-0.018140676,0.0028889806,-0.019359993,0.042740107,-0.08031674,0.0065870397,-0.03842437,-0.03934791,-0.026228245,-0.06300572,-0.09418215,0.0049794572,0.024322625,-0.061111607,-0.04653014,-0.05132703,-0.010199652,0.018802738,0.09992696,0.012526586 +3.3.2.7,"Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide [2]. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].",384,0.99999994,0.0051631164,-0.099290386,-0.095552586,-0.024709886,0.06578346,0.040343806,-0.048949543,0.016984817,0.028931143,0.00070922106,-0.024918742,0.005423444,-0.036031928,0.025332773,0.035066467,0.0023244177,-0.08594559,0.058879577,-0.01905273,-0.10578807,0.0655865,-0.015567975,0.07119445,-0.027742945,0.030783752,0.0063336445,0.03761352,0.017065987,0.050546,-0.018302653,0.0035958197,-0.06590478,0.058153935,-0.06961483,-0.004086012,0.060723167,-0.07880285,-0.088584185,-0.08516501,0.027718332,0.05206431,0.018072778,-0.028799709,-0.08352465,-0.048815057,-0.08479801,-0.04894704,-0.04828549,0.011747103,0.018052934,0.017262714,-0.043196056,-0.01349418,-0.0419486,0.0022308987,-0.0084829,-0.07574158,0.0047117826,-0.045815706,0.030852921,-0.011980117,-0.01699024,0.053457636,0.03646671,-0.016998827,0.014452331,0.033226408,-0.102484286,-0.04718714,-0.013255023,-0.06381391,-0.03947906,0.06955839,0.054480635,0.0077817542,0.019675149,-0.019371228,-0.033499494,-0.034130692,-0.055225518,0.048147053,0.008449025,0.010594157,0.18570705,0.032529812,-0.01655653,-0.10045876,-0.009341133,-0.05697443,0.09941363,-0.002976759,-0.017224466,-0.059446316,0.047172338,0.04073103,0.06617686,0.0468326,0.0021912993,-0.0081644645,-0.042322826,0.0153117515,0.121769756,-0.0661787,-0.04078801,0.008064319,0.085379995,-0.03255148,0.040929697,-0.05605184,0.03464061,-0.0033507426,-0.03802352,0.016142651,-0.067992,-0.018502425,0.048906896,-0.01574182,-0.079184085,0.034025285,0.07511074,0.019330366,0.020416316,0.037948955,0.012510062,0.032155726,-0.008776059,-0.00929856,2.9601025e-33,-0.024106871,0.051071763,-0.07334267,0.021995723,0.005476987,0.06883611,-0.06909911,0.023574516,-0.012069997,-0.004356862,-0.04266493,0.011171663,0.06810927,0.04611654,0.014230296,-0.0010859784,0.022043647,-0.0018715826,0.058019847,-0.0073766364,0.06817911,-0.06719591,-0.07802753,0.030146698,-0.03739096,0.025104813,0.00607143,0.04046973,0.036839247,0.0020452766,-0.005258662,-0.0526496,-0.045003306,-0.0409029,0.028281724,0.030117672,-0.02706257,0.016866382,-0.022939231,0.07615934,0.060616385,0.011786001,-0.061160736,-0.032286674,0.025784781,-0.0900438,-0.019161655,0.063305855,0.10495464,-0.018873967,0.06359704,-0.008575531,0.13232772,-0.007713966,-0.049415536,0.011268102,-0.019539936,0.021588277,0.038290292,0.033688493,-0.036842883,0.0015335979,-0.065613024,0.06298141,0.044336442,0.07148611,-0.06578475,-0.07917534,-0.09237716,0.033023667,0.005691024,-0.010669126,0.024454672,-0.008511206,0.0030874254,0.012856688,-0.0764826,0.075857595,-0.015593965,-0.0154063925,-0.049353186,0.01844544,0.05380461,0.05225578,-0.09096432,0.026758507,0.00031753845,-0.028527435,0.011605172,0.0064137112,0.09139104,-0.0880233,-0.00900151,-0.017602896,0.0044633797,-5.1971235e-33,0.035153244,-0.0067403177,0.0110548595,-0.11776701,0.012127738,0.14388996,0.025351552,0.043414477,0.0854242,-0.019065075,0.05206501,0.05140664,0.020201927,-0.109278485,-0.01731821,0.054081354,-0.035014,0.0524122,0.04054724,-0.021507597,0.06260513,0.06549355,-0.01722905,0.15437709,0.010646561,0.049133867,-0.017009877,-0.05269361,-0.012252244,0.099755995,0.0036895291,-0.05092494,-0.012508152,0.039584003,0.0035098821,0.02031914,-0.062256884,-0.018725941,-0.084029,0.02549278,0.026999189,0.02030466,0.080092825,-0.03551646,0.11353088,0.12167377,-0.07956339,0.037201043,0.01627298,-0.0148814125,-0.070764184,0.003127853,-0.015681995,0.073306225,0.06643204,0.02537624,0.0068500056,-0.048731297,0.05229864,-0.051704228,-0.06292191,0.0014905048,0.05243737,0.08843621,-0.024424851,-0.014730417,-0.06877096,-0.013819924,0.04151512,-0.028176138,-0.0337286,0.018552052,-0.044416975,-0.024659088,0.014465301,0.032718647,-0.016979283,-0.023448171,-0.050661422,-0.014254371,0.034238014,0.057621196,0.0044892444,0.0063709016,-0.07234604,-0.045276366,-0.027501032,0.12937841,0.018063443,-0.034365296,0.026025912,0.0033630056,-0.14301763,-0.04231595,0.04973233,-5.2414247e-08,0.024005784,0.021247681,0.023934245,-0.016265023,-0.07185092,-0.017000265,0.012228845,0.031303875,0.040086944,-0.06571493,0.032044657,0.029872706,0.035727795,-0.04167036,0.015480583,-0.009213661,-0.0039563496,0.0022025995,-0.011420006,-0.050806955,-0.11090446,-0.012997842,0.018060284,-0.02757425,0.06993591,-0.040602304,-0.08777083,-0.051647656,-0.007244668,0.02400875,-0.050532073,0.005404733,0.0017371768,0.006608844,-0.035954647,0.023843186,0.06410196,0.002545072,-0.04682408,0.00090841786,0.002080025,-0.09280631,-0.065712444,-0.006812807,-0.005746784,-0.002089383,-0.007747654,-0.014157811,0.024897134,-0.07040623,-0.030964375,-0.025516834,-0.006333971,-0.063310936,-0.081788845,-0.07993671,-0.1177969,-0.10025035,0.001510113,-0.1252982,0.032956272,0.040909465,0.14022209,0.030180592 +3.3.2.8,"Involved in the monoterpene degradation pathway of the actinomycete Rhodococcus erythropolis. The enzyme hydrolyses several alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. It differs from the previously described epoxide hydrolases [EC 3.3.2.4 (trans-epoxysuccinate hydrolase), EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase) and EC 3.3.2.10 (soluble epoxide hydrolase)] as it is not inhibited by 2-bromo-4'-nitroacetophenone, diethyl dicarbonate, 4-fluorochalcone oxide or 1,10-phenanthroline. Both enantiomers of menth-8-ene-1,2-diol [i.e. (1R,2R,4S)-menth-8-ene-1,2-diol and (1S,2S,4R)-menth-8-ene-1,2-diol] are metabolized.",384,1.0,0.011385656,-0.09116499,-0.040380176,-0.026445169,0.0896661,0.062217478,-0.04967064,0.055602904,-0.011349162,0.037077904,-0.02366772,-0.022933068,-0.013741981,0.05890769,-0.05026643,0.030183028,-0.06340738,-0.02014054,0.03061452,0.036030088,0.09977722,-0.037763964,-0.032321196,-0.016615344,0.04323452,-0.026484957,0.036915682,0.014519981,-0.08430872,-0.07605994,0.034169327,-0.08960679,0.0858198,-0.025573954,0.00895416,0.07449742,-0.008789529,-0.045818042,0.040597267,-0.008796949,-0.010335458,0.024271416,-0.005232764,-0.04078169,-0.041240066,-0.0073470306,-0.01576395,-0.0014030834,-0.005673897,-0.004302522,0.03666142,-0.034312733,-0.03591143,0.030380912,0.06901467,-0.011480711,-0.0066632843,-0.0034750986,-0.05507235,0.017305514,0.076851666,-0.07273381,-0.0009579665,0.010989579,-0.08630954,-0.04429758,0.053040497,-0.053132456,-0.0379128,-0.0028802168,-0.091613024,-0.07250436,-0.002870881,-0.0010053733,0.01881321,0.049082227,0.015442147,-0.026378727,-0.04418081,-0.040454585,0.037303194,0.02514259,0.014985106,0.07511775,0.059160218,-0.0007204444,0.007567983,-0.06932046,0.073584616,0.07476723,0.06738891,0.0143878255,-0.00515835,-0.010117739,0.015976198,0.033210475,0.024431095,0.055265747,0.0023691885,-0.04038358,-0.0020706444,0.019943768,-0.06241126,-0.12730384,0.014736551,0.03479193,0.017705427,0.051669337,0.044967122,0.0049853316,-0.041819923,-0.032678425,-0.0015004897,0.026167827,-0.026978692,0.019845877,0.053588487,-0.0716004,-0.054724798,0.007889796,0.018094547,0.014315642,0.094600655,-0.026698489,-0.04998845,0.025360722,-0.021353062,5.8516847e-33,-0.026685044,-0.030561624,-0.054706275,-0.033918433,0.04465446,0.07399812,-0.089663796,0.08730355,0.016705772,-0.11723117,-0.0270284,0.00061721104,0.026182987,-0.010500228,-0.027780734,0.034918126,0.013867282,0.039239466,0.026278457,0.0021960326,0.003166636,-0.038152643,-0.09975189,-0.0007099041,-0.019116167,0.0429749,-0.013126749,-0.004342614,0.052071407,-0.057210065,0.036087956,-0.085182846,-0.11295806,0.014131591,0.018065158,-0.015294141,-0.010300357,0.026490396,0.02702475,-0.051396552,-0.0021617063,0.08903125,-0.051726718,-0.024079172,0.04577118,-0.13107307,-0.02755766,0.11088127,0.081769206,0.035109237,0.019693239,-0.030167047,0.09688935,-0.017486196,-0.0038901109,0.013422756,0.006992231,0.07579391,0.092893004,0.0058914754,-0.004955993,0.10022002,0.037879303,-0.023158189,0.046746768,0.03979916,-0.08567695,-0.05756229,-0.06373079,0.07748915,-0.012918465,-0.023084806,0.12396498,-0.024365226,0.017349973,-0.09473281,-0.031087713,0.042519648,-0.016412418,0.04054114,0.03293422,0.021291923,0.03491918,0.011890267,-0.055310104,0.042173702,0.01490027,-0.0070079034,-0.010569611,0.1119576,0.08105127,-0.096944466,-0.08082138,0.03328253,-0.00020039603,-5.4382244e-33,0.14242275,-0.070374615,0.06742298,-0.06254837,0.012149442,0.10730632,0.029547062,0.025174323,-0.009380381,-0.10856695,0.112977125,-0.010891869,0.013347972,0.0011175625,0.06583996,-0.046684716,-0.025817288,0.09077738,0.016551446,-0.013561978,0.027124094,0.084641345,-0.02303926,0.08645279,0.018810252,-0.029125994,-0.00014906708,0.03021899,-0.015599351,0.054739323,-0.009919239,-0.020868333,-0.09165145,0.025340568,-0.046108004,0.04222485,-0.095934965,0.009905387,-0.024404958,0.033319324,0.04775778,0.024479134,-0.046916105,0.010680351,0.06663531,0.10595227,-0.13322182,0.048249032,0.010909878,0.018025715,-0.01189372,-0.0056763226,-0.11889787,0.0064915423,0.07421614,0.0289457,0.025600191,-0.021827519,-0.016597657,-0.02523207,-0.091973975,0.032092195,-0.0022964722,0.029933656,0.008975616,0.06858753,-0.06584306,0.10260893,0.027034212,-0.0037521187,0.044419233,-0.012379438,0.030223731,-0.06403652,-0.0030210796,0.017663052,-0.02522728,-0.06916618,-0.051761698,0.0074302847,0.057545803,0.04542163,-0.016948583,0.009217723,-0.0833019,-0.07219412,-0.020914534,0.082361646,-0.06392799,0.032259267,0.060334217,-0.009779756,-0.027528267,0.04635004,0.091470174,-5.4987897e-08,0.068306185,-0.03041189,0.11317616,-0.050668947,-0.020634437,-0.058912966,0.026408609,-0.0045406744,0.06899905,-0.06713463,0.05703217,0.024707686,0.009920407,-0.005186533,0.07380116,-0.037803,-0.027145535,0.022297014,-0.021397704,0.084344886,-0.07769703,-0.069957346,-0.069542624,-0.005054953,0.033404958,-0.07186039,0.06256728,-0.03030271,-0.04214868,-0.010767098,0.010576308,0.0020992998,0.013599046,0.06742103,-0.025613923,-0.021740898,-0.046349168,0.044471696,-0.11394476,0.048337314,-0.012669941,-0.08647544,-0.037632346,-0.0058305915,-0.0053752153,0.031205727,-0.030833067,0.005854582,0.04341402,-0.017244447,0.0034041372,0.011546589,-5.7374582e-05,-0.0918408,-0.10488428,0.020414686,-0.01358014,-0.018273637,-0.037726507,-0.027690085,-0.00076638267,0.003326327,0.14183444,0.002304049 +3.5.1.3,"Acts on glutaramate, succinamate and their 2-oxo derivatives.",384,0.99999994,-0.052857567,-0.068991,-0.04855224,0.06030029,0.0414421,0.048914157,0.008535898,0.014969213,0.012977188,-0.0034375757,0.073460735,0.018169908,-0.027099632,0.061772637,-0.014093771,0.08423936,-0.023549706,-0.0018194332,-0.07121726,0.056609917,0.06948596,0.013455258,-0.056055,0.0033193794,0.056238472,0.06592187,0.0025398117,-0.0348264,-0.0320386,-0.05306854,-0.026213532,-0.057438597,-0.019069863,-0.037364926,-0.0054985452,0.022087997,-0.066409275,-0.048264686,0.070185766,0.02622978,0.04736391,-0.028318342,-0.033446867,-0.041885555,-0.007357255,-0.022485489,0.03887077,-0.0076378644,0.013376023,0.042943753,-0.03616644,-0.09646838,-0.090672076,0.05360763,-0.010808911,-0.0049913037,-0.14817597,0.035002533,-0.008506227,-0.009528354,-0.023506401,0.0045305165,-0.026828373,0.041627605,0.009534145,-0.062249232,0.04055081,-0.045554005,-0.021425989,0.037267387,-0.0444569,-0.061839364,0.09162255,0.015439987,-0.010015312,-0.011564874,-0.012370914,-0.064534925,0.04190743,-0.012121355,0.06124859,0.016112298,0.06504425,0.11533244,-0.0057817064,0.065421574,0.053238846,-0.0068218145,0.0031078486,0.010357838,0.0664436,-0.015332613,-0.067236476,-0.02752055,0.01064841,0.030004356,-0.00779148,0.06969762,0.006283939,0.003404119,-0.04790764,0.015880076,-0.05517593,-0.10718264,-0.010724048,0.013111125,-0.017431784,-0.025448909,0.01043029,0.07176834,-0.02892035,-0.029167386,-0.004796498,-0.027122546,-0.058064792,0.1024624,0.049051683,-0.030895429,-0.094094075,-0.08437747,0.063310504,-0.032282438,0.0883514,0.05309303,-0.078604124,0.042555563,-0.051958583,-1.1932804e-33,0.031579137,-0.060954183,0.01405149,0.01820023,0.029211013,-0.04369668,-0.11332138,0.009956863,-0.014901211,0.034806315,-0.09391903,-0.001973718,0.0074996618,0.0076244096,-0.0497722,0.007316587,-0.03082062,-0.027853582,0.031997003,-0.037464682,0.040276147,0.13606703,-0.0064533623,0.044414178,-0.08201385,0.006922378,-0.00045729062,-0.019911915,-0.009062425,-0.031979684,0.10704147,-0.05002485,-0.08968211,0.032315154,-0.036858838,0.008779224,-0.15386038,-0.07532113,0.021826494,-0.0058227717,-0.014410936,0.06332241,-0.06359194,0.0026141948,0.03006229,-0.03504646,-0.040730074,0.074749894,0.095731735,0.07049475,0.01816735,-0.032561954,-0.019246714,0.043968003,-0.040304236,0.019777419,-0.018842472,0.008905388,0.08919734,0.02636942,-0.03458283,0.00669561,-0.013283558,-0.070612386,-0.06260151,0.049308915,-0.11830478,0.030320834,0.0054653776,0.0026514693,0.008563099,-0.051340953,0.038923297,0.031583354,0.036152776,-0.04705275,0.030217616,0.051022943,0.028766211,0.059002765,0.023481358,-0.033088,0.03266445,0.07738921,-0.09375792,-0.016455544,-0.008727109,-0.03463263,-0.013466235,0.10849885,0.014818965,-0.0075179944,-0.05100758,-0.071489766,0.02470825,-1.4981089e-33,0.0587336,-0.12184509,-0.014989996,-0.03059888,-0.054749206,0.03623434,-0.05189493,-0.067557685,0.0030708085,0.006648188,0.0640372,0.08775848,0.026932843,-0.02004582,0.01821369,-0.04881252,-0.0060244747,0.02648644,-0.029104171,-0.011629506,0.019496195,0.1229343,-0.0069925827,0.03456286,0.09092954,-0.044391442,0.086804084,-0.002305838,0.056499425,0.10101666,-0.034617413,-0.007962325,-0.06786565,0.009181584,0.031661157,0.0054883775,-0.00772828,0.039976686,-0.09472653,-0.0059217005,-0.031213554,-0.025057826,0.072391585,0.11494341,0.09717035,0.07563299,-0.08955255,0.0114540355,-0.088705234,-0.019695185,0.007820408,-0.02135551,-0.09114639,-0.032222167,0.06529748,0.05530689,-0.021533076,-0.08698303,0.019951478,-0.06780368,0.035963874,-0.016272688,-0.014158486,-0.09349301,-0.013699179,0.07970321,-0.0069086854,0.005511419,0.028331831,-9.815171e-05,0.067232326,-0.054141432,0.04045498,-0.046418265,-0.008482569,-0.088510975,-0.016690088,-0.094135664,-0.028272217,-0.04721134,0.0050970293,0.040403876,0.014138207,-0.02976415,-0.041110873,0.013695368,0.037720345,0.11785616,-0.0059417454,0.03346849,-0.05114924,0.04126541,0.015866108,0.065112375,0.058392502,-2.4507743e-08,-0.0718939,-0.048682496,0.10843834,-0.008875348,-0.029653883,0.0072760377,-0.014612393,0.0026316524,0.01381328,0.036376163,0.009746966,0.12341509,0.050166275,-0.02985175,0.01129457,-0.012151348,-0.031090593,0.046579424,-0.05761417,-0.02038984,-0.121010005,0.009951421,-0.033144474,0.017639771,0.028700614,-0.074820854,0.05282496,0.0031460454,-0.04289207,-0.06885906,0.07924883,0.033817586,0.079916194,-0.020416973,-0.07586747,0.036147714,0.021362115,-0.015106274,-0.032404605,-0.014678695,0.0011227239,-0.073798366,0.064532064,0.05331242,-0.016974749,0.014724181,0.037208207,-0.002700602,-0.0011085238,0.06276311,0.0700633,-0.0108971195,-0.025327366,0.0095007755,-0.07748917,-0.015852887,-0.0036863855,-0.026672455,0.069668576,-0.025797032,-0.019824302,0.006349143,0.15915668,-0.0022622056 +3.5.1.5,"A nickel protein. Urease catalyses the hydrolysis of urea to yield ammonia and carbamate, which spontaneously hydrolyses to form carbonic acid and a second molecule of ammonia. In aqueous solutions the products convert to ammonium and hydrogen carbonate. The enzyme is widespread and is found in many bacteria, some archaea, and many eukaryotes, including plants, some invertebrates, and numerous eukaryotic microorganisms. Urease is one of the earlier enzymes to be studied, first obtained In 1874 [1,2], and named urease in 1890 [3]. The crystallization of urease in 1926 was a significant landmark in biochemistry, showing for the first time ever that enzymes are proteins and can be crystallized [4]. In 1975 it was found that the enzyme contains nickel ions in its active site [5,6].",384,1.0,-0.06985989,-0.002760259,0.0006114804,-0.028508415,-0.02314742,0.05890119,-0.0010048526,0.052555732,-0.038062137,0.045591857,-0.036172543,0.011569342,-0.062134102,0.07277284,-0.07645966,-0.006034059,-0.10451572,0.010060779,0.023268754,-0.03452763,0.10248562,0.019900244,-0.06591202,-0.09088508,0.003763188,0.05926254,0.031893957,-0.100763865,-0.0216509,-0.10016977,-0.01420257,-0.083086774,0.029377215,-0.11286809,0.10103418,0.049415696,-0.032066733,0.0020822394,-0.04674324,-0.032014456,0.050217193,-0.042912614,0.033413112,-0.03492917,-0.010726391,0.04576845,0.123706944,0.028555172,0.012009038,-0.07435096,-0.0022554134,-0.07600507,0.030289853,-0.0023217432,0.023973873,-0.025123378,-0.10659833,-0.01576135,-0.037665326,0.0047098952,0.032817002,0.006284403,0.036041334,-0.09376981,0.041426487,-0.0016935306,0.04376783,-0.079619475,0.0060626855,-0.055861134,-0.041690413,-0.041754466,0.0001012272,0.028652929,-0.067684844,0.013160922,0.013000114,0.014167053,0.0013954352,0.005986966,0.010116506,0.005968311,0.057558987,0.018319288,-0.028243288,0.0003849216,0.025140788,-0.0020795797,0.009936165,-0.064040825,0.0109216785,0.04331844,0.012279464,-0.014841792,-0.050591864,0.0054971953,0.017040227,0.033562984,-0.017120546,-0.04296105,0.07043923,0.066220365,-0.0024307566,-0.09862183,0.0043367925,0.03340143,-0.024508968,0.14140055,0.05466992,0.05985005,-0.004222267,0.020021487,0.02203649,0.021407709,-0.0041668443,0.018502135,-0.011112406,-0.04236257,-0.10169028,0.030598775,0.015625505,0.028081615,0.036203314,0.05093647,-0.072204985,0.09228316,-0.075088136,1.6820555e-34,-0.01388946,0.04611616,-0.03676455,-0.005391243,-0.0096672205,-0.0679095,-0.052043516,0.027104022,0.01844796,-0.0958798,-0.0433278,-0.034346953,0.017481718,-0.053383905,-0.14472994,0.02135832,-0.017327366,0.075901695,0.039582126,0.029155904,-0.028340742,0.022730062,0.010851178,0.014466562,0.043150067,0.011712949,-0.009730248,-0.090713985,0.109211534,-0.025085412,0.10545719,-0.058825053,-0.08968644,0.0007193567,0.07156591,-0.01973942,0.09419973,0.009086351,-0.060887776,0.023305926,0.012836062,0.024153227,0.020505983,-0.06548885,0.098623,-0.06837758,0.003010826,0.07980646,-0.014184894,-0.058333136,-0.009939656,0.019825278,0.02867356,-0.00445382,-0.08457614,0.039974872,0.008838908,-0.018925887,-0.0033073616,0.027581181,0.022387588,0.1039793,-0.04228011,-0.027135363,-0.05299569,0.0034402716,0.000148915,-0.02876788,0.0073224497,0.09594661,-0.065134026,-0.0025072473,0.053544372,0.014535804,-0.009562703,-0.10582047,-0.02635196,-0.06344332,0.091605246,0.008709619,0.07012578,-0.04307046,0.0430635,-0.047085572,-0.021419976,-0.088397615,-0.057830576,-0.0061876117,-0.047583036,0.025074404,0.043256946,0.0053563784,-0.06434033,-0.0074353074,-0.045592345,-1.4204065e-33,0.1169801,-0.07541181,-0.02697973,0.016117325,0.031684738,0.035369366,0.037741512,0.01491529,0.007285611,-0.045493573,0.12206145,-0.036185488,0.07175175,-0.019952202,-0.002352565,0.011437598,-0.001758996,0.050440006,-0.010982691,0.0070617744,-0.07676038,0.0063239443,-0.037891645,-0.058165863,0.046205357,0.049573638,0.0051850984,-0.021263182,0.074608885,0.02736465,0.046251338,0.014467384,-0.08250252,-0.12163535,-0.025575323,0.045350585,-0.034787163,-0.057210866,0.068686105,-0.031774033,0.047314446,-0.011283891,-0.039240297,0.068229,0.05351424,0.0025858227,-0.064009465,0.06127872,-0.024756268,-0.044697024,0.06412895,0.0038192878,0.01597522,-0.014062027,-0.015862526,0.048321698,0.0029114895,0.08934371,-0.051198617,0.111684866,-0.029171837,-0.03544745,0.0445355,-0.039548773,-0.03993789,-0.0015986762,-0.04300488,0.079449564,0.003922462,-0.021320513,0.01564864,0.0015416709,0.07029977,0.020597504,0.0040192236,0.06603785,0.011211177,-0.029807257,0.039276633,-0.09744988,-0.045103014,0.06651428,-0.0059640575,-0.038062286,0.10530614,-0.043764636,0.06465769,0.121477894,-0.026453828,0.045000784,-0.028843423,-0.068428345,-0.06635224,0.09697882,-0.0067639956,-4.3369287e-08,0.06844354,-0.027838293,0.049692705,-0.024563342,-0.019388746,0.10681187,0.09972693,0.02378145,0.024708364,-0.042814583,-0.01798872,0.061317835,-0.0698472,0.044774026,0.054819982,0.014496529,-0.021844637,0.03859424,-0.041706294,0.055085886,0.024141297,-0.012309476,-0.09817338,0.003880068,0.008792301,-0.044343267,0.019296536,-0.017727653,-0.12210708,-0.053631585,-0.004566624,0.05680602,0.03716821,-0.0040726387,0.023956245,0.05199766,0.048204605,0.013651105,-0.05563215,-0.06826417,-0.01808546,0.03923564,-0.06686365,-0.039220188,0.079144284,-0.0053666583,-0.032462712,0.059742015,-0.019347051,0.01001763,0.010996761,0.010209664,-0.016705548,-0.087465025,-0.049218822,0.08158526,0.010812844,-0.1160716,-0.017035922,0.011185229,0.0613976,0.011981953,0.045026336,-0.008859795 +3.5.1.6,The animal enzyme also acts on beta-ureidoisobutyrate.,384,1.0,-0.03707495,-0.05325319,0.0023908399,0.043908533,-0.05380248,0.043164514,-0.051948275,0.00427761,0.014178479,0.018426092,0.008709977,0.021215657,-0.071006365,0.09767632,-0.031039558,0.057933435,-0.056374203,0.050057605,0.06286525,-0.02307537,0.10124402,-0.0021396703,-0.036122836,-0.032530613,0.04425472,-0.021880886,0.04380436,-0.059175123,-0.026830932,-0.07611986,-0.039506286,-0.055502653,0.042569317,-0.029492704,0.01983014,0.05363178,-0.08109085,-0.12370052,0.018664222,0.051252384,0.071100086,-0.052214622,-0.046416603,-0.013398837,-0.02189136,-0.018968087,-0.025848793,0.013704261,0.05874269,0.028596403,-0.10230818,-0.094819084,-0.022562204,0.045340795,-0.023878971,0.025247738,-0.050744627,0.0040752254,0.004316272,-0.005953031,-0.009966492,0.033259794,0.006100352,0.0013865476,0.07532291,-0.0076257014,-0.032823645,-0.03950228,-0.022442479,-0.079742126,0.014642033,-0.04714355,-0.006835825,0.0029732,-0.016508305,-0.029187793,-0.052796707,0.010918674,0.052548572,-0.042404108,-0.009962509,-0.06989094,0.04016277,-0.0062710256,0.081456795,0.02827721,0.04580698,0.0070293196,-0.070609555,0.059687413,0.03176347,-0.03312009,-0.050341558,-0.019727813,0.058031823,-0.037083816,0.012498038,-0.026765965,-0.008501851,-0.039103813,-0.050521255,0.019562371,-0.019629886,-0.0433556,0.018791469,0.05649052,-0.0005242299,0.06057369,0.018379055,0.051875513,-0.031220198,0.037670072,0.09661273,0.072791696,-0.006660537,0.075404786,-0.045729138,-0.037623774,-0.06316959,-0.0014799378,0.046447534,-0.055471174,0.016496634,0.04496794,-0.061964642,0.05371252,-0.0491466,-2.1953878e-33,0.10559158,-0.0036694938,-0.052725688,-0.054905128,0.0039455057,0.03146709,-0.05976287,0.0018630596,-0.019793732,-0.058726232,-0.06358566,-0.026870564,0.02084299,0.03447977,0.009801277,0.034844168,0.0012824292,0.08043534,0.12936552,-0.043481708,-0.0010637534,0.02565749,-0.026187984,-0.017276922,0.02705979,-0.0101704355,-0.06677146,0.0341855,-0.04468387,0.025189554,0.05274368,-0.08895967,-0.08246327,0.01991765,0.04912798,0.022409357,0.014914207,-0.08065806,-0.08138778,0.030845553,0.021310076,-0.033532366,-0.010197625,-0.03544415,0.08314791,-0.047708735,-0.019717008,-0.004462444,-0.00407812,0.063440695,0.038826194,-0.011377767,0.09461823,-0.026969831,-0.058843624,0.024978554,-0.046259943,-0.10314172,-0.05592722,0.06202299,-0.021082664,0.06972772,0.047036644,-0.034396883,0.0056505245,-0.017281502,-0.07132443,-0.04774133,-0.045119125,0.06978923,-0.02668937,-0.033294298,0.03627894,-0.06418116,-0.036566935,-0.07665375,-0.041139115,-0.010751474,0.028943192,-0.082950965,0.012570664,-0.019863578,-0.00057612016,0.0019305714,-0.0030901567,0.04036093,0.054506354,-0.03793885,-0.0075500836,-0.03271034,0.1545071,-0.029004328,-0.09642061,0.031889953,0.08637928,4.1084455e-34,0.11696515,-0.138151,0.046240523,-0.028610762,-0.05452628,0.070222676,0.044601846,0.017369367,0.00972112,0.02460895,0.016558258,0.012558333,-0.022441594,-0.11834044,0.020425592,-0.008470878,0.02811773,0.012919904,0.0021086559,-0.05396108,-0.043947272,0.060262203,0.015136361,0.023502296,0.016860334,0.020678865,0.04342611,0.026686272,0.10414662,-0.022183174,0.0032225423,0.040784217,-0.08177531,-0.10870001,0.024437865,0.085321896,-0.048148587,0.037789937,0.037077982,-0.03270007,0.06992438,-0.00662608,-0.06606892,0.028637035,0.08367484,0.0782323,0.0064093904,-0.036635067,-0.024078617,-0.06069169,0.099345386,-0.02671249,0.049688768,0.023371207,-0.0013232459,0.03050214,-0.11128773,0.026061874,-0.014422209,0.0011724613,0.04685749,-0.0011945575,0.029697245,-0.004157453,-0.008164023,-0.01395984,-0.0055992412,0.038007688,0.056647625,0.03208431,0.06009073,0.0006812005,0.017765427,0.04439012,-0.0056287125,-0.021659464,-0.07050779,-0.07271033,0.028712545,-0.03704174,-0.07186764,0.07636886,-0.042081807,-0.045455854,-0.010220633,-0.0669199,-0.03258646,0.17330092,0.045970205,0.04522657,-0.05259992,-0.009330247,-0.09182579,0.024352765,0.08129404,-2.2439174e-08,0.06189684,-0.013740412,0.05632164,-0.010898413,0.012466102,0.0065441276,0.035838924,0.049678702,0.04263731,0.0033645832,-0.045947954,0.08276443,0.036064006,0.061087545,0.058316913,0.009439495,0.010817771,0.0184117,-0.001214782,0.026114523,-0.08887422,0.010279931,-0.060427368,0.059133206,-0.01328738,-0.123315565,0.056631714,0.07351224,-0.0774762,0.023608783,0.019647622,0.049107112,0.016869355,-0.077376075,-0.011108747,0.07961455,0.049281847,-0.026073966,0.039863948,0.0016781192,0.00036495583,-0.060484275,-0.020465596,-0.008735167,0.0061090053,-0.019904837,0.055097587,-0.040266518,0.035489257,-0.06251319,0.013829884,0.0020334674,-0.091051705,-0.087690346,-0.07225837,0.04165572,-0.029151177,-0.09316767,0.029008407,-0.028882382,0.11503782,-0.023348007,0.16441058,-0.07407703 +3.5.1.9,Also acts on other aromatic formylamines.,384,1.0000001,-0.06337629,-0.09070065,-0.048265297,0.015837898,0.05005047,0.023376511,0.057087436,-0.0075174626,0.06915562,0.00011992262,0.03842251,0.036811877,-0.06773279,0.07802395,0.0029727593,0.09651804,-0.032637637,-0.0026528689,0.009802121,-0.010064866,0.02737113,-0.00010628101,-0.011371687,-0.012515149,-0.051667616,0.046566933,0.046124063,-0.00370887,0.06419822,-0.028837292,0.0058118673,0.029449232,-0.04943413,-0.011296567,0.01101003,0.03068403,-0.07099643,0.02527787,-0.011745572,0.026160084,0.025990834,-0.039186943,0.0009127402,-0.06648531,-0.029558878,-0.021088097,0.028334761,-0.006541727,0.021913575,-0.025719352,0.0010869487,0.0032903343,-0.008912785,0.058219235,-0.05995636,0.02130909,-0.08990097,0.0391819,-0.093484625,0.025315808,-0.075796776,0.032840222,-0.036419563,0.0024095366,0.0068622613,-0.0027667133,0.011227879,-0.0041917013,0.051367413,-0.03875089,0.010938346,-0.036232553,-0.002301845,-0.02588232,0.043536562,-0.042956,-0.03294817,-0.08092631,0.01226656,-0.035973452,-0.04868347,0.02254203,0.010297142,0.033673875,0.07345766,0.017603572,0.00052734173,-0.0436881,-0.002522687,0.022408722,0.008028996,-0.05427953,-0.04188339,0.03761959,-0.046870492,-0.03433169,0.07666071,0.033059385,0.012204876,0.022983601,-0.018791229,-0.012849887,-0.14297065,-0.06430859,-0.07011411,-0.018922282,0.05958326,0.029494058,0.0047332463,-0.0017061597,-0.023419458,0.0052899756,0.04815255,0.058263123,-0.050696902,0.06455498,0.060983382,-0.010627198,-0.065831825,-0.04137196,-0.010211276,-0.025545383,0.0132265,0.046664197,-0.08967363,-0.006737986,-0.04114501,-2.0380232e-33,0.02246381,0.022841433,0.048167128,0.021119958,-0.0035454887,0.032014932,-0.08631269,-0.0123400055,0.022832926,-0.07526061,-0.0377451,-0.017527798,0.052249473,0.017955003,-0.006587043,-0.08381942,-0.07137201,0.07526822,0.057588402,-0.074295215,0.01831568,0.11387385,-0.05643456,-0.009461696,-0.04389168,-0.0091096945,-0.027890526,0.030475019,-0.07110733,-0.016075462,0.044705532,-0.015706956,-0.09334694,0.05224876,0.0063314415,0.16468464,-0.09609361,-0.047677897,-0.012439902,0.00596528,0.002635139,0.0036457658,-0.061168738,0.008200082,-0.037144314,-0.040999822,-0.08600651,0.083099924,0.02489586,-0.014143396,0.010486357,-0.043994147,0.11202758,0.011323175,-0.029301265,0.053608533,0.007323204,-0.12590863,0.017301682,0.0057579353,-0.013946441,-0.012263992,-0.08826501,-0.016898878,0.0038567584,-0.0037571213,-0.015908152,0.012700086,0.012087157,0.05150439,-0.06673582,0.04749079,0.075800814,0.0074482625,0.0165395,-0.02767407,-0.050396327,0.0060182777,0.07637207,0.10996083,-0.017168164,-0.1615664,0.0452262,-0.02649673,-0.07157175,-0.0077996897,0.03250713,-0.05616708,-0.004918341,0.030276775,0.06706512,-0.13439508,-0.027589362,0.006037042,-0.011273208,-6.315227e-34,-0.0020796685,-0.09972581,-0.0070485603,0.01479898,0.021389214,-0.0001637687,0.05643969,-0.023397302,-0.02392005,-0.00053522456,0.060080096,0.024875207,-0.018340478,-0.0055875964,-0.0064531453,-0.007839805,0.04465735,0.093811944,0.010031768,-0.02949509,-0.075123414,0.0783614,-0.01607471,0.07398823,0.028528327,0.033325326,-0.027801482,-0.0037589984,-0.007833362,0.0680052,0.01050435,-0.015556481,-0.09064373,-0.015459418,0.022661015,0.0346125,-0.028619446,-0.017824525,-0.053246863,-0.04502787,0.022153731,-0.0072265808,0.106644884,0.13414343,0.035662133,0.0797583,-0.057914995,0.0004426315,-0.08319129,-0.03050239,0.021064097,0.041811418,-0.057668712,0.010226053,0.05086737,0.08307626,-0.023496214,-0.07506107,-0.0013241884,0.014455354,-0.013063766,0.031714093,-0.06734715,-0.07656632,0.0008263466,-0.023754066,-0.020082943,0.039420582,0.15093726,-0.053570163,0.15287803,0.01211912,0.07661729,0.026819296,-0.09739776,-0.11513741,0.025421193,-0.033110518,-0.022098906,-0.08185848,-0.006033244,-0.07854234,0.016833698,-0.06790814,-0.06175395,-0.055368725,6.375242e-05,0.0459185,-0.032683145,0.006542625,-0.026065798,0.05311564,0.023077453,0.0874421,0.017415365,-1.7018898e-08,-0.021948429,-0.0176625,0.093316086,-0.05323069,-0.07698466,0.003818609,0.13084304,0.06201903,0.00041373871,-0.06609673,0.015624458,0.0708018,0.09582917,0.016250925,0.0763345,0.010126732,-0.041683804,0.009555184,-0.06547193,-0.078912154,-0.09329133,-0.009453174,-0.054558337,0.06199679,-0.018684056,-0.03308661,0.038381122,0.0932733,0.04574288,-0.037786942,0.012900398,0.020510975,-0.0065755863,0.03996402,-0.006164357,0.071899496,0.025337687,-0.055308353,-0.009733756,0.060679805,-0.0037614484,-0.031386405,-0.040736724,0.033756867,0.06217866,0.017556483,-0.036775634,0.025264982,0.016241433,0.019911395,0.06412014,0.02531287,0.014935539,0.014470378,-0.06849371,-0.009382709,-0.011672348,-0.016050553,0.10294285,-0.019539302,0.039976124,0.021149378,0.17872508,0.048222493 +3.5.1.12,"The enzyme, found in many bacterial species as well as animals, liberates biotin from biocytin and short biotinylated peptides, but not from biotinylated proteins. It also has activity on biotin esters and biotin amides.",384,1.0,-0.087738864,-0.11057286,-0.025805015,0.023007484,0.085377686,0.101166055,-0.059004113,0.029128479,0.037826773,-0.024539009,-0.00312221,0.014066577,-0.088420406,0.09635139,-0.03045157,0.025225408,-0.08133684,0.03545955,0.03516252,-0.002210787,0.07223241,0.04027722,0.02419089,0.033979222,0.010846138,-0.04948554,0.048496872,-0.045163956,0.038670845,-0.035427168,-0.033677187,0.0057661673,-0.034672562,-0.002228236,0.041172616,0.09496658,-0.019179704,-0.044714306,0.07435991,-0.023780784,0.05346123,-0.04142945,0.007301542,-0.051708054,0.013383595,-0.03882109,-0.04042348,-0.06813195,0.0659149,-0.0063768486,-0.085317776,-0.0064832624,-0.02132642,0.03547959,0.053938374,-0.052207384,0.037940416,-0.05698869,0.01283908,-0.008871428,0.03590549,0.04916838,0.00066217576,0.03120909,-0.062494107,-0.092965126,-0.026861409,-0.008582972,0.022875773,-0.060204003,0.0035129648,-0.098847896,0.016372325,0.048965205,-0.0147622805,0.010661849,0.00083833106,0.023123758,-0.06472654,-0.03853766,0.018009808,-0.09210359,0.009449472,0.15260266,-0.008807231,-0.08929867,0.02005987,0.048084274,-0.021264233,0.0065881074,0.018385261,0.022704724,0.0077908374,-0.10339576,-0.038855802,-0.07942874,-0.01789607,0.016851654,0.035492267,-0.026199033,-0.03373599,0.065439135,-0.042654924,-0.105432056,-0.037655823,0.011181297,-0.037801795,0.07826363,0.09741376,0.023547767,-0.008226272,0.090424985,0.0430421,0.017001316,-0.013887526,0.070657276,-0.0019328153,-0.10228271,-0.03781743,0.077453226,-0.019782798,-0.025402918,0.1218119,0.12928063,0.039392587,0.050468937,-0.07997112,1.6139929e-33,0.04518328,-0.111094795,0.013005714,-0.03438915,-0.025545621,0.0063705,-0.073543884,-0.045706525,0.019915301,-0.10603058,-0.028734626,0.015315882,0.033974037,0.054077923,0.0468225,0.0016879753,0.02280455,-0.0747052,0.06791538,0.020025369,0.019658953,0.027549203,-0.0009977823,0.04393231,0.041784886,-0.025292326,0.05652656,0.004307909,0.048789013,-0.03175068,-0.036046624,-0.1058432,-0.0755463,0.016477328,0.09355266,0.04749731,0.005029273,-0.045424134,-0.002563595,0.07082553,0.05279587,0.03383016,0.040253215,-0.09595611,0.07143199,-0.018150667,-0.07044929,0.047255095,0.006973262,0.05172243,0.05275,-0.02547466,0.024670128,-0.03731641,-0.07992767,0.06217832,-0.035813197,-0.03953208,-0.007301357,0.009479443,0.06479597,-0.053304322,-0.034621134,-0.014061753,0.06373118,0.044129055,-0.032711178,0.014314632,-0.013635946,0.057099096,-0.060928766,-0.017671023,0.10335461,0.006702083,0.027992258,-0.03518789,-0.13455087,-0.0048211017,0.05363897,-0.014500721,0.031296846,-0.04536518,-0.028281493,0.032782074,-0.033726245,0.017212665,0.0063741514,-0.017387727,0.010518704,-0.05482764,0.014234299,-0.11252169,-0.05760114,0.04663272,-0.07650869,-5.1089218e-33,0.04038223,-0.05873252,0.085229255,-0.031119818,-0.013637249,0.0314244,-0.035239127,0.010839867,0.010631827,-0.022600163,0.05986109,-0.05053672,0.057320446,-0.025328351,-0.011234479,0.061996408,-0.104586944,-0.024561135,-0.02528027,0.007482129,-0.037850227,-0.07542147,0.023526408,0.015821962,0.057969704,0.05520517,-0.090553015,0.09288431,0.02153914,-0.05421509,-0.017532932,0.041810647,-0.053770553,-0.11594409,-0.029871155,0.0084408345,-0.055134706,-0.031724665,0.03651792,-0.02869677,0.056624375,-0.013304981,-0.009468002,0.019938426,0.05062694,-0.009796364,-0.106385514,-0.03866215,-0.005534993,-0.03331157,0.047319826,0.015206247,0.0073200255,-0.057817597,-0.032586325,0.012086195,0.0023542142,0.103021145,-0.025179744,-0.01276871,0.029581789,-0.022903483,0.05062391,0.024760434,-0.03585181,0.04757625,-0.017252186,0.04509157,-0.0141179105,-0.03271449,0.064861186,0.029539015,0.100106165,0.060333367,0.0316501,0.0018366496,-0.037051428,-0.072088175,0.054760884,-0.031922325,0.02812213,-0.00019174958,-0.04229652,-0.07707044,-0.025342476,0.010317696,0.038638823,0.02017885,0.0039206594,0.0022449163,-0.043582674,0.004805963,-0.006825303,-0.0015660527,-0.013880329,-3.3493045e-08,0.052954417,-0.025474345,0.040193185,-0.009332746,-0.042077463,0.006952453,0.023571543,-0.0030131661,-0.030595135,-0.019135,-0.02527448,0.004499674,-0.13313693,0.045909543,0.012103278,0.012490963,-0.040207017,-0.036459204,0.010652912,-0.0014649862,-0.07799028,0.05316673,-0.07908143,0.07823349,-0.03929971,-0.036604796,-0.055453673,0.0025747225,0.015257067,-0.03726662,-0.043864626,0.06371627,0.01999912,-0.06554304,0.01173395,0.030861316,-0.029887151,-0.09596784,-0.033856727,0.039097715,0.06983364,0.0057082167,-0.05581009,-0.04508967,0.029805299,-0.014883306,0.050792634,0.0554534,0.0086982185,0.06766437,0.08069179,-0.005235625,-0.052945647,-0.08736466,-0.08624367,0.02468637,-0.012961815,-0.07889152,-0.00037032622,-0.05263671,-0.044332806,-0.06780891,0.18893044,0.05807545 +3.5.1.13,Also acts on 4-substituted anilides.,384,1.0,-0.024063753,-0.03213687,0.009030664,0.04969069,-0.048655927,0.041064363,0.038210902,-0.007905532,0.08206229,0.03231288,0.09566309,0.019395782,-0.060502734,0.091079526,-0.015053559,0.066166416,-0.094986334,0.07209296,-0.047532454,-0.006192882,0.005294389,-0.061691277,0.01394181,-0.018759696,-0.023260178,0.0163423,-0.016542224,-0.022966497,0.11600219,-0.11454574,-0.001583652,-0.0166555,0.025739139,-0.015114162,-0.046681233,0.059934128,-0.0050151455,-0.003226424,0.00727011,-0.005556876,0.074096404,-0.052153464,-0.02369568,-0.026274147,0.013630072,-0.030702975,0.015092825,0.005995608,0.028742919,-0.002782856,-0.0050603347,-0.031991474,-0.028043201,0.019295385,-0.06758829,-0.018083429,-0.10026273,0.0060505318,0.04357307,0.02249415,0.013012503,0.003913177,-0.063048095,0.045993038,-0.030880759,-0.0058962125,0.07964601,-0.08824218,-0.080168724,0.056595203,0.0003554485,-0.11020491,0.060544394,-0.017083978,0.06848994,0.038635068,0.04432627,-0.059904855,-0.027828714,-0.011141469,0.008860301,-0.031125976,-0.01611789,0.03930884,0.08088674,0.010629718,-0.06598361,-0.10579631,0.08456027,0.034394465,0.012315242,-0.03165022,-0.009832606,0.002810876,-0.016171765,0.0025696962,0.0055314093,0.061525766,0.0068833623,0.047413476,0.03771647,0.04203189,-0.08838623,0.033499904,-0.020771079,0.005973908,-0.02539573,-0.058152795,0.028718716,0.021485208,-0.062996805,-0.07471489,0.04040309,-0.039350223,-0.06740718,0.020903746,-0.03943174,-0.0010991747,-0.01010405,6.274226e-05,0.04076947,-0.031623624,-0.024898138,0.015451793,-0.0651796,-0.010782431,-0.08318924,-2.2055426e-33,0.06552199,0.088172786,0.00044177755,0.06326915,-0.007366815,-0.029932521,-0.0633775,-0.0024781355,-0.03913576,-0.114072725,-0.060145743,-0.05343899,0.019315269,0.04409424,0.010085979,-0.017117716,0.063236296,-0.039256457,0.075097516,-0.044378325,-0.013347705,0.0883501,-0.055147704,0.018564917,0.047778893,0.054402333,0.04502194,0.012957527,0.0055504767,0.02657579,0.00033776782,-0.005663227,-0.085891016,0.037445724,0.072957374,0.0814432,-0.041122727,0.0013296315,-0.010901458,0.025845392,-0.042113222,0.026114127,-0.06540033,-0.019931572,0.06815628,-0.06006261,-0.021744465,0.08881785,0.026302299,-0.0038256135,0.022386475,0.019511912,0.058306836,-0.0038277167,-0.043267254,0.059632212,-0.04672839,0.04707384,0.05655854,0.022060366,0.021227721,0.010425497,0.006289537,-0.02632106,0.004962616,0.03958946,-0.040713925,-0.050408337,0.000535848,0.0014130524,-0.07289002,0.031578936,0.08618553,0.07680137,0.04033524,-0.019183235,-0.0034746085,-0.026133213,0.06679428,-0.035434987,-0.061831504,-0.030092755,0.04962393,0.094900064,-0.06369963,-0.061523903,0.080578014,-0.07493123,-0.0031847327,-0.061096117,0.09030889,-0.060063783,-0.053355336,-0.059696566,-0.025753539,7.2117194e-34,0.029189482,0.0074641183,-0.08840017,0.06822736,-0.0751917,-0.04279195,0.06156436,-0.0281397,-0.031668358,0.0026875916,0.085738875,-0.011745054,-0.011958071,-0.08172792,0.017793426,0.120824665,0.021761639,0.03343727,-0.04408998,-0.047330815,0.016958246,0.086554825,0.036230348,0.059256468,-0.028541293,0.06396724,0.011552516,-0.054321878,0.03358242,0.09043231,-0.037894692,-0.013643191,-0.040595084,-0.05207994,-0.008110973,0.06896475,0.00552208,0.014657385,-0.036716785,0.022837076,0.04990071,0.01576359,0.16512783,0.09816728,0.019137891,0.022953797,0.043235008,0.062991895,-0.03454584,-0.08813197,0.026349254,-0.026635913,-0.0703104,-0.03639345,0.052752946,0.012274861,0.05643739,-0.14105386,-0.056165487,-0.05592228,-0.07935472,-0.028526567,0.056478392,-0.09237072,0.056735173,0.0012596686,-0.060065806,-0.014026925,0.061628822,-0.0933178,0.09806104,-0.03404862,-0.023021618,-0.06036708,-0.046094332,-0.08752013,0.011017882,-0.085322134,-0.01296859,-0.02378322,-0.077738866,-0.022270124,0.05819851,-0.048812494,-0.051638648,-0.088160016,0.001909081,0.073247515,0.019598596,0.020906454,0.06702429,0.102729,0.058180247,0.08040636,0.061151166,-1.6833265e-08,0.016027562,0.010424284,0.017238159,-0.040944126,-0.012482515,-0.0022013967,0.0060521555,0.016612498,0.01986516,-0.036071885,-0.020499047,0.054892473,0.029384194,-0.046464223,0.0711736,0.05806228,-0.04825498,0.05281768,-0.10141304,-0.016201958,-0.11096825,0.03064658,-0.06873872,-0.052304044,0.001626972,-0.02554429,-0.046347793,-0.040568266,0.02252796,-0.012253616,0.046224903,0.03825747,0.003293869,-0.08097649,-0.042747967,0.016709048,0.041005135,-0.06011843,0.007737544,0.085774586,0.0010326626,-0.049270652,-0.015656235,0.10110189,-0.006467036,0.031249555,-0.077995464,-0.015535243,-0.020952335,0.049190763,0.03107525,0.047662575,-0.0075514903,0.00878277,-0.07155751,-0.046928488,0.009516542,-0.012435102,0.09294367,-0.103558056,0.05211506,0.046942726,0.078141786,0.024136446 +3.5.1.14,"Contains Zn2+. The enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). It acts on mercapturic acids (S-conjugates of N-acetyl-L-cysteine) and neutral aliphatic N-acyl-alpha-amino acids. Some bacterial aminoacylases demonstrate substrate specificity of both EC 3.5.1.14 and EC 3.5.1.114. cf. EC 3.5.1.15, aspartoacylase and EC 3.5.1.114, N-acyl-aromatic-L-amino acid amidohydrolase.",384,1.0,-0.023008708,-0.08672418,-0.03180789,0.00015201804,0.12082982,0.07236274,-0.02774387,0.04721618,0.060200546,-0.049303155,0.0050468184,-0.040241145,-0.0018968134,0.076281466,-0.09762462,0.0045243027,-0.03986046,-0.07105336,0.032878663,-0.06468149,0.0040061153,0.07358679,-0.02790582,-0.025782455,0.041330576,-0.05316527,0.06760755,-0.017776927,-0.037428927,-0.016154842,0.022203218,-0.099304326,0.08703253,-0.0016733247,0.095084034,0.031329177,-0.039580647,-0.058243845,0.07930535,-0.014151106,0.04308633,0.019162962,0.013890552,-0.074093685,0.007271365,0.015181684,0.056991573,-0.026201788,0.03322526,0.021993283,-0.08590122,-0.07360491,0.00044690087,0.018257145,-0.020434605,0.047940888,-0.10302207,-0.083694264,-0.07421857,0.022436481,-0.025440456,-0.005685738,0.033489015,-0.054759245,0.02082672,0.0015466475,0.023184927,-0.08127741,0.017126182,-0.04146393,-0.08036349,-0.074107,0.05112309,0.016442768,-0.013667598,-0.059871513,0.0070197615,-0.04925071,0.03156907,-0.09364312,0.017300097,-0.0129624065,-0.0064423634,0.094565906,0.037770793,-0.036138263,0.00086891843,0.04036291,0.030653117,0.02154961,0.00514311,-0.0010051463,0.022493068,-0.04264608,-0.025413033,0.02006502,0.031774975,0.044320125,0.04679226,-0.012960954,0.015825441,0.08980238,0.04206042,-0.122193225,-0.036638085,0.077670895,0.024874149,0.1145046,0.002259382,-0.008164353,-0.031838443,-0.019579237,-0.0028693185,-0.022937527,0.018568058,0.04265594,0.054899167,-0.04477795,-0.082874246,-0.033704147,0.007181803,-0.0387484,0.1165975,0.05869513,0.010217651,0.1254783,-0.11347706,1.4806935e-33,0.02680202,-0.011311657,-0.026763033,-0.017946234,0.024789136,0.018662283,-0.05328604,0.060905788,0.04986258,-0.05915189,-0.043666337,-0.08618117,0.030653868,-0.040652808,0.00059256074,-0.05199253,0.007948052,0.022730237,0.009955137,0.06282156,-0.00093735673,0.033197965,-0.013699548,0.010316265,0.030613795,-0.029064653,0.0022418734,-0.00502931,0.05974202,-0.02058093,-0.0049309116,-0.0708172,-0.12372068,-0.04382019,0.1189479,-0.0020027258,-0.02886337,-0.012536449,0.0110299885,0.054173537,0.021723611,0.04581017,0.04016716,-0.015458998,0.015980726,-0.008449334,-0.07926488,0.109983206,0.025517669,-0.023536306,0.05679807,-0.04151229,0.106682405,-0.03234908,-0.014867571,0.0344258,-0.06300708,0.042807523,0.057688326,0.037915736,-0.017949168,-0.0019697337,-0.06775744,0.02328553,-0.035939638,0.04401319,-0.034894414,-0.025624327,0.025471566,0.07832103,-0.061957,-0.00724421,0.08124469,0.0852582,0.025961138,-0.13328469,-0.1021211,0.047084417,0.07589952,0.0037983668,-0.015482194,0.021900939,0.035540406,0.04038724,-0.014155578,-0.015292068,0.025988111,-0.05437051,-0.0021463356,-0.004027098,0.012390079,-0.09831927,-0.081410974,0.03564901,0.007782302,-2.1961763e-33,0.078368366,-0.08632849,-0.022662546,-0.058107745,-0.08846239,0.0531136,0.014752173,-0.0045439145,-0.012381795,-0.06126497,0.09155491,0.04283582,0.021424955,-0.051478352,0.020460512,-0.011393114,-0.012372691,0.10482541,0.04944297,-0.057198223,0.007908645,-0.012906233,0.053152066,-0.025158329,0.087729126,0.037433144,-0.01348164,0.08947219,0.077753656,0.07524051,-0.024818495,0.037367612,-0.010924587,-0.124246545,-0.045595627,0.03153488,-0.03636835,-0.0330751,-0.044597287,-0.021984298,0.060522143,-0.0013057679,0.012141639,0.08099701,0.030450834,0.069876485,-0.043015447,-0.010094595,-0.050009202,-0.029510973,0.034794196,-0.066869035,0.00020748035,0.00010959784,0.021320425,0.08721711,0.034639,0.049329504,0.040577322,-0.027115872,-0.04554473,-0.05492958,0.018649215,0.03665068,-0.005887594,-0.020601654,-0.0591897,0.04722668,0.031698216,0.0066951597,0.00036604452,-0.0020947277,0.044305798,0.047230978,-0.047448494,0.029224321,-0.063870914,-0.021384027,0.037628014,-0.030204397,-0.010285802,-0.025538528,-0.02295055,0.0019308061,-0.03175172,-0.05701504,0.083639406,0.09742774,-0.03431182,-0.00029585802,-0.018188952,-0.06629997,-0.09474816,0.02638181,0.0013083882,-4.795317e-08,0.04877907,-0.0466538,0.04108926,-0.06346782,0.041974124,0.043007996,-0.033290714,-0.036430813,0.011462311,-0.04787962,0.008023769,0.037486326,-0.034947395,0.035319075,-0.048269227,0.030704753,-0.0058024176,0.043462146,-0.03591177,0.09240282,-0.065990806,0.034319162,-0.104151174,0.0044372,0.024859915,-0.051852863,-0.0018831074,0.07430723,-0.07132628,-0.076213785,-0.057879154,-0.0036268241,0.08554291,-0.07256266,-0.00049332454,0.01938032,-0.022978093,-0.11514799,-0.0063947747,0.015837196,0.02663219,-0.002288598,0.01168614,-0.013134564,0.053996224,0.0007511611,0.006752012,0.044362262,-0.036295064,0.03678929,0.006090631,-0.06634772,0.0010260756,-0.088525586,-0.05331967,-0.011439757,-0.0020944565,-0.12155518,0.04598759,-0.0044917683,0.009336735,0.0608014,0.17895488,0.014214792 +3.5.1.16,Also hydrolyses N-acetylmethionine.,384,0.9999999,-0.0011553611,-0.084453985,-0.07450686,0.02948322,-0.019551389,-0.02372185,0.020785835,0.05839376,0.023685513,-0.06667888,0.01693609,0.01442147,-0.039233074,0.035776787,-0.09471327,0.043389633,0.036751613,-0.0050817668,0.009173123,-0.03363343,0.041009866,0.07034067,-0.028125403,0.00927838,0.020958243,0.0631367,0.050398603,0.024709206,0.013540625,-0.06860622,0.07229587,0.015151908,0.015699783,-0.04886819,0.028422246,0.06453041,-0.070034534,0.007678507,0.026447719,0.019665258,0.04164236,-0.04076175,0.003245996,-0.042332724,0.0072533414,-0.027579311,-0.020433431,0.012093831,0.08980113,0.09158903,0.041257594,-0.07486881,-0.026886962,0.05438906,-0.019501127,-0.0053170733,-0.15215994,-0.020597456,0.0025568276,0.051530056,0.021752588,0.075303696,-0.010019992,-0.002253677,0.027337292,-0.007638507,0.051352102,-0.05249786,0.0056324564,0.01836128,0.040732242,-0.052590758,0.038045224,0.024433153,-0.049638774,-0.024290167,-0.0128037995,-0.07205526,0.07094276,-0.02812329,-0.0018365907,0.060559005,-0.009426891,0.10286731,0.08936699,0.029618306,-0.0023074048,-0.017308122,0.00049986294,-0.0067099,-0.007756167,-0.04180815,0.011707635,-0.0010531998,-0.036461484,-0.036860723,-0.0005957179,-0.0007402315,-0.08842262,-0.005774724,-0.04636638,0.07657452,-0.011410942,-0.052580293,-0.031725615,0.027957436,0.07550376,0.03691206,0.04942783,0.0026791757,-0.07098689,0.015738785,0.0059700115,-0.016658718,-0.032015495,0.059290335,-0.005813412,0.02613056,0.024031898,-0.010350952,0.003433876,-0.049672343,0.035732284,0.015556572,-0.007496238,0.07805909,0.0053582573,1.1482431e-33,0.010180226,-0.023162603,0.07029837,0.022849401,0.04744349,0.027498405,-0.07112964,-0.03858438,0.070163235,-0.0780373,-0.038777526,0.01260354,0.010120254,0.040127642,0.000509178,-0.063530415,-0.008379443,0.001702081,0.073476486,-0.06731634,-0.036090296,0.07007908,-0.057929385,0.032977458,-0.09151757,-0.05303574,0.029429616,0.041250993,0.11504,0.00043652867,0.026254142,-0.013504477,0.0011111208,0.0032101567,-0.06947303,0.056995127,-0.039646845,-0.054404493,0.048646905,0.10152448,0.0062652673,0.019889439,-0.011786902,-0.026372436,-0.0031887884,-0.046179388,-0.11257726,0.052273646,-0.016952392,0.009306001,0.052703917,-0.042936347,0.070852615,-0.021374894,-0.063316025,0.009715978,-0.06716414,0.009475676,0.016550526,0.052994933,-0.040982813,0.048628576,0.009055215,-0.02290426,-0.058777038,0.01735073,-0.022885203,-0.048588797,-0.01553589,-0.03243082,-0.109538995,0.034219332,0.15382771,0.07875572,0.031533007,-0.061684143,0.027890224,0.043178044,0.017820792,-0.0068193963,0.017982641,-0.03325398,0.055386797,0.06419762,-0.027856374,0.006074867,-0.026271129,-0.07655971,0.008859298,-0.025279514,0.026113393,-0.06432655,-0.06751555,-0.011223576,-0.029849738,-2.2117154e-33,0.041752197,-0.10539621,0.008947544,0.035743307,-0.018141897,0.049541425,0.06650275,-0.013014674,-0.028951641,-0.0748266,0.09627377,-0.0120086605,-0.03745059,-0.06877602,0.031417098,0.009191775,0.021355411,0.047882244,-0.011142085,0.019330293,-0.011461803,0.065706566,-0.008184382,0.043216117,0.096453436,0.0014096039,-0.04781134,-0.013743216,0.03931066,0.07538268,-0.004505969,-0.009695531,-0.07577631,-0.1022362,-0.06554622,0.053352967,0.04068811,-0.034491986,-0.14823645,-0.052203424,-0.033854377,-0.0050669787,0.071026556,0.099175125,0.032156184,0.1237905,-0.026538504,-0.04399061,-0.05953303,0.027640224,0.011028301,-0.03243813,-0.075949796,0.10417024,0.06778962,0.0632455,-0.022165958,-0.0060331025,0.03431142,-0.041583702,-0.019873587,-0.021158839,-0.03128792,-0.08153176,0.015996974,0.031708173,-0.07432874,0.05151067,0.031386998,-0.039591733,0.038691703,-0.015937151,0.043732595,0.06700341,-0.017728416,-0.053969223,-0.006662004,-0.16987133,-0.067629375,-0.0870148,-0.037489135,-0.0052987533,-0.07481967,-0.06446448,-0.03664945,-0.020219214,0.047468692,0.078363284,-0.016642885,0.05817929,-0.024964279,-0.05059133,-0.13696745,0.033283364,0.038827576,-1.9676325e-08,0.043408018,-0.07081571,0.066269234,-0.05786109,-0.009691945,0.03621065,0.07574264,0.0601906,0.03573938,-0.119362324,-0.018713938,0.08391572,-0.008545267,0.032799616,-0.043776598,-0.0043664514,0.015866006,0.05579614,-0.039622314,-0.007734739,-0.14363962,0.009663362,-0.0035627603,-0.0043243016,-0.0037473869,-0.043942656,0.08376056,0.067635246,0.04239775,-0.04697268,0.011092254,0.012286003,0.040547196,-0.09625299,-0.021402583,0.06437836,0.012209432,0.023903735,-0.022768028,0.010765718,-0.032640245,-0.04187476,-0.0011936135,0.048174907,0.10364193,-0.054019213,0.0052048364,0.077331185,-0.011742823,-0.017684512,0.026286572,-0.02218903,0.012820368,-0.0825408,-0.050233006,7.6352626e-05,-0.013004566,-0.068685,0.012589721,-0.024357157,-0.033282544,-0.033903055,0.18094066,0.053376306 +3.5.1.24,"Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on choloyl-taurine.",384,1.0,-0.028187694,-0.13571002,-0.012338455,-0.004698513,-0.026005484,0.044872344,-0.0007595772,0.0012184004,0.04642443,-0.0349938,0.065166794,0.034711637,-0.09569179,0.025042484,0.06416675,0.05740646,-0.061100855,0.014265575,0.016805094,0.010262387,0.036766104,-0.060681574,0.008661126,-0.00030218475,0.016130604,0.017875232,0.07769551,0.035801355,0.0037185568,-0.071054205,-0.0072666868,0.009408747,-0.026480416,-0.078903876,-0.015416512,0.019561725,-0.095561706,-0.02184531,0.042791612,0.008795949,0.088768356,-0.017157871,0.020765,-0.011663171,-0.020668736,-0.049213037,-0.013139254,0.035189666,0.018312367,0.038896006,-0.004405806,-0.016064575,-0.033495814,0.09892473,0.0023280252,0.11221522,-0.1589283,-0.019297954,0.039788656,0.020556794,-0.09518695,0.01605954,-0.04199284,0.014220789,-0.0010947636,-0.013069013,0.024539337,-0.061426774,-0.0011145874,0.0056879385,0.016830316,-0.052074943,0.04445132,-0.031330436,-0.031007083,0.018075986,-0.026395237,-0.048376687,0.052769355,-0.06636502,-0.026512794,-0.016347768,-0.0024923221,0.066764206,0.112021536,-0.019738525,-0.042294487,-0.07356018,-0.0896556,-0.029326532,0.0054578185,-0.054029748,-0.048985742,-0.0045448714,0.0012183846,0.034716114,0.045162912,0.0006486436,0.015515108,-0.00262211,-0.0044363,0.022866989,-0.05673035,-0.09381337,-0.0941433,0.054867633,-0.02282944,0.0015420445,-0.054551765,0.022914879,-0.052380268,-0.0632944,0.043740943,-0.033089392,-0.006738849,0.094305135,0.020719709,-0.068469875,0.008137028,-0.030379107,-0.03180648,-0.0648754,0.0069627273,0.023735046,-0.084696576,0.07829435,-0.02483811,-9.050106e-34,0.08875358,-0.00083141326,-0.044741612,0.012211702,0.057140194,-0.0015107773,-0.090994865,-0.049202688,-0.06680431,-0.008404218,0.04155934,-0.029686797,0.0442926,0.02262953,-0.06844324,-0.0104769245,0.009174538,0.014196808,0.047118798,-0.069622636,-0.014034203,0.13247949,-0.07263399,0.00977272,-0.067548506,0.01487293,-0.03164333,0.042925112,0.018222058,0.04164681,0.07283501,-0.015337803,-0.06693358,0.041849606,-0.01632142,0.07873253,-0.12409967,-0.04883822,0.020239593,0.00022048375,0.09373632,-0.04737564,-0.03941632,-0.007600756,0.0043441695,0.004462567,-0.002485818,0.007122851,0.059463076,0.0159228,0.06719429,-0.052061934,0.059534542,-0.026954692,-0.018533431,0.021769335,-0.03332632,-0.03894245,0.044500202,0.07954795,-0.01824256,0.01854243,-0.012032322,0.011413778,0.03609832,0.026059791,-0.06570562,-0.053390663,-0.07586653,0.046415698,-0.010637333,0.021670667,0.080913715,0.03289693,0.052133523,0.03739006,-0.038584195,0.061398245,0.005460388,0.032197364,0.012298145,-0.025715247,0.041221555,0.04198252,-0.060236085,0.009225614,-0.035997346,-0.072714075,0.01533604,0.015294951,0.083999,-0.04400496,-0.048064698,0.03932971,-0.024969611,-1.6181695e-33,-0.0005865594,-0.088279545,-0.03293614,-0.057797357,-0.04976745,0.10838982,0.045537345,-0.007676558,0.08639825,-0.00849563,0.113874145,0.015768481,-0.0959727,-0.09649089,0.01223264,-0.0043029073,0.0732126,0.07661398,-0.02051215,-0.043424867,-0.022635974,0.09327093,-0.045868903,0.15976965,0.0458171,0.029786214,0.010744856,-0.040055316,0.05602903,0.12570328,-0.012031209,-0.013681727,-0.03944257,-0.04712139,-0.03805606,0.006383622,-0.028471647,-0.0031421103,-0.08016879,0.02319378,0.0029210025,-0.0020205525,0.11808965,0.028772514,0.06751901,0.060578465,0.02795037,-0.012795927,-0.05739304,0.041404963,-0.0035590997,-0.09932293,0.019356519,0.021465963,0.058810093,0.10859361,0.026298882,-0.094364144,0.02761183,-0.06526268,-0.036695722,0.05947277,0.019766575,-0.053318072,-0.013313034,0.02176666,-0.041424543,-0.05964611,0.05430731,-0.00061549904,0.01055732,0.03602462,-0.028010868,0.05321289,-0.04407674,-0.05696075,-0.010657826,-0.04114958,-0.015267741,-0.037223347,0.03171111,-0.022610025,-0.0044231685,-0.029375507,-0.028599832,-0.05638822,-0.05246206,0.103543304,0.07971656,0.026717218,0.005885778,0.0069484473,-0.10032374,0.034684666,0.02906819,-2.7567223e-08,0.024994137,-0.031319376,0.013868452,-0.028388469,-0.052680664,0.013975006,0.08448554,0.02857609,0.015190005,-0.03420852,0.001864725,0.14219205,0.0873759,-0.048088633,-0.0148276845,0.020503443,-0.0030207448,0.024878526,-0.06152401,-0.06317458,-0.07028688,0.020844003,0.07660468,0.01273364,0.018856056,-0.03637699,0.010037095,0.04298948,0.0006307662,-0.041082453,0.053086407,0.0067786244,-0.044495054,-0.07345033,-0.0328093,0.0452418,0.037558984,-0.06742491,0.0058792843,0.074792504,0.029945053,-0.027645161,-0.012055314,0.042243313,-0.008929596,0.012556695,-0.07852259,-0.04693934,-0.018789247,0.031443246,-0.043100826,0.019288968,-0.014363752,-0.034151204,-0.118144736,-0.03065101,-0.047876865,-0.058689374,0.040645808,-0.08157507,0.03861576,0.051744927,0.17886575,0.039810773 +3.5.1.26,"Acts only on asparagine-oligosaccharides containing one amino acid, i.e., the asparagine has free alpha-amino and alpha-carboxyl groups [cf. EC 3.5.1.52, peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase]",384,0.99999994,-0.0065318835,-0.14065814,-0.08168432,0.037614107,0.017590182,0.08485541,-0.058875468,0.039666016,0.09177641,-0.05166925,0.03530125,-0.0026461354,-0.043173075,0.04963566,-0.04109779,-0.04687031,0.021117771,-0.055509612,-0.039495815,-0.094297335,0.0078931,0.002131773,0.01198597,-0.016283225,0.028290367,-0.09614609,0.02174128,-0.10675418,0.010744935,-0.10351229,0.016676778,-0.10253488,0.057758078,0.031379323,0.09770855,0.04714243,-0.025725488,-0.0668235,0.036187857,-0.0155408755,0.03483602,-0.0053879377,-0.020018563,-0.0016110984,-0.023735832,-0.04510944,-0.013712537,0.041088905,0.09051424,-0.013593998,-0.06899008,-0.07283838,-0.07540019,0.02834014,-0.06686008,0.057798427,-0.13629884,-0.033271547,-0.025645336,0.07051427,-0.052332953,0.042991824,0.028977174,-0.048403446,-0.033060476,0.0189617,0.04114034,-0.015557268,-0.024351073,0.032959547,0.0073420065,-0.05024916,0.04490425,0.072702415,0.01601139,-0.064544864,-0.08095747,0.0053169667,-0.007113652,-0.037855305,0.07354325,-0.021284766,0.02194355,0.05334876,0.013242768,-0.01805419,-0.012211333,0.016945297,0.069989264,0.0076218746,0.029430658,-0.021254292,0.0028665685,-0.01752508,0.016048934,-0.08415231,0.045155425,-0.0019919605,-0.024511011,0.013156074,-0.05089615,0.0096831815,-0.025688048,-0.03007797,-0.0010717598,0.06124941,-0.008558722,-0.0072323685,0.046681046,0.057754356,-0.0360387,-0.048979305,0.015059802,-0.080395475,-0.097223766,-0.018400757,-0.003921563,-0.052031953,-0.053396977,-0.06965268,0.024313433,-0.008492166,0.07403681,0.11182963,0.017551014,0.07721455,-0.0357174,1.7942101e-33,0.043431606,0.016026849,0.09515441,-0.056736525,-0.030063845,0.024208609,-0.01785891,-0.012069,0.04467595,-0.06123951,-0.053062428,-0.0848787,-0.00026094148,0.020862356,0.061167493,0.00021054395,-0.008781893,0.010794345,-0.036890604,-0.02794072,-0.032610107,0.10469009,-0.022639908,0.085130446,-0.0007886991,-0.0940179,-0.04854769,0.019006148,0.08764172,0.004040725,0.05296108,0.009296484,-0.1653934,0.036245555,0.059196033,0.026520945,-0.04863624,-0.07079831,0.031313367,0.041583292,-0.05178834,0.029884221,0.029729238,-0.107804574,-0.013389826,-0.07724889,-0.038715735,0.04604577,-0.008100147,0.03694867,0.019206068,-0.024104448,0.069702744,0.0017272255,-0.017767318,0.02804778,-0.0856306,0.006339758,0.045719635,0.093386106,-0.0060307197,-0.08895165,0.0073829484,-0.08975139,-0.032436147,0.05444709,-0.05650332,-0.0038444698,0.008218548,0.07057161,-0.03440887,-0.03083357,-0.0005009034,0.053525217,0.036398154,-0.030423013,-0.053005725,0.05017021,0.03557624,-0.056636762,0.014830888,0.022237659,0.039389703,0.06407617,0.025123192,0.034629505,0.050091162,-0.008194834,0.05520413,-0.00027683412,-0.01473679,-0.02857143,-0.08982281,0.09645301,0.027015531,-2.0999676e-33,0.08518342,-0.07121987,-0.0058901412,0.06312747,-0.044413652,0.024687927,0.026361743,0.009842458,0.0349543,0.040878527,0.05475741,0.05964049,0.02133516,-0.020352187,0.017103966,-0.025901636,-0.007551736,0.09413307,-0.011312806,-0.01505829,-0.026869198,-0.026133375,0.042212676,0.024275316,0.053043984,0.0085472055,-0.019227877,0.0595465,0.031483695,0.059621636,0.042156737,0.06818753,-0.041399207,-0.097784266,-0.05557689,0.026166515,0.0154606365,-0.006728305,-0.0580187,-0.020666301,0.034793064,0.059478283,0.059472714,0.08488147,0.03796832,0.052080877,0.020200104,0.043728657,-0.059524454,-0.03673086,0.0055542532,-0.043396987,0.041105516,-0.012331986,0.009949033,0.02761759,0.06741708,0.008899071,-0.028487723,-0.014589196,0.005166133,0.006809804,0.0419901,-0.09515102,0.042321425,-0.06169488,-0.02307502,0.026097711,0.056359388,-0.012755645,-0.03165266,-0.053418107,0.049918514,0.045227326,0.024294103,-0.039053634,-0.034732696,-0.05985577,0.033424504,-0.0555103,-0.035346624,-0.027912416,0.015903074,-0.022246437,-0.037953276,0.04599028,0.12128253,0.118583664,0.0055458196,0.11068722,-0.028960116,-0.025636014,0.038040563,0.11886855,0.0504961,-3.898489e-08,0.12044685,0.07903392,0.013682239,-0.05754819,0.008187107,0.015811732,-0.02351448,-0.00047417468,-0.013245088,0.014841345,-0.049697574,0.010730725,-0.055312917,0.029208299,-0.06787551,0.03411514,-0.053202435,0.04870116,-0.021259438,0.07203741,-0.049550485,0.034236096,-0.08153993,0.024761867,0.017270964,-0.07748647,0.041931257,0.08299333,-0.06478103,-0.010832354,-0.017523412,0.0366849,0.055240028,-0.111193076,-0.05596669,0.00931056,-0.015710633,-0.015025551,0.06401132,0.02163611,-0.0027730702,0.003914236,0.05639308,-0.03656502,-0.0059786737,0.04717819,0.06051343,-0.027199104,-0.0719905,0.07573198,0.01645039,-0.052909017,-0.043024164,-0.028139291,-0.06528539,-0.03851651,-0.09253228,-0.07192827,0.09036856,-0.07525221,-0.024580002,-0.058404814,0.110000856,0.016479248 +3.5.1.29,Involved in the degradation of pyridoxin in Pseudomonas.,384,1.0,0.0300614,-0.046728082,-0.044394206,-0.030071061,0.06531205,0.060836665,-0.07107951,0.06609213,-0.018463794,-0.033504553,0.030099414,0.0018542623,-0.031740822,0.12517856,-0.036395457,0.019871345,-0.07887168,0.017564612,0.04329494,0.057606988,0.031079587,0.06142806,-0.05698949,0.06204658,0.0036040186,0.05609421,0.05462411,0.018448591,-0.058383677,0.03924058,-0.084436044,-0.042468805,0.020988455,-0.09360794,0.0780119,0.036019478,-0.065859415,0.047983,0.12819926,0.0010504592,-0.011199152,-0.010281861,-0.060010742,-0.036159765,-0.00997734,0.03493199,0.044169176,0.024010232,0.06520791,-0.073762804,-0.065426126,0.019862907,0.036988843,0.06522088,0.010244584,-0.009022509,0.032808017,-0.025684472,-0.071074545,-0.035153292,-0.017157929,-0.057103075,0.0026335856,-0.014789871,-0.019504495,-0.019621903,0.021077635,0.008191165,0.027126158,-0.0025794087,-0.043454103,0.004464759,0.09418034,0.010731314,0.044289604,-0.0027490943,-0.025719766,-0.06797069,-0.06230509,0.0031344616,0.025118623,-0.04170395,0.033493903,0.023431959,0.043744244,-0.038212303,0.012721045,-0.011157237,-0.02674524,-0.002472067,0.059166893,0.04686579,0.02366148,0.0070073153,-0.015935667,0.04960978,0.00070464954,0.09105247,0.02015792,-0.07767605,-0.043443177,-0.018134372,-0.14140801,-0.063851655,0.0491646,0.031073313,0.06272009,0.04015882,0.037023958,0.023134194,0.013139648,0.01332977,-0.06627919,-0.044352893,0.0426962,0.014922725,0.1064458,0.014331492,-0.0944287,0.07715177,-0.00087869924,-0.02521451,0.005144153,0.044129413,-0.008867422,-0.05714254,-0.029121114,-2.1964744e-33,-0.0029322878,0.030733714,-0.06836658,-0.031558357,0.070447065,-0.04145985,-0.027016139,-0.091218695,0.033701636,-0.03377192,-0.0017957274,-0.018010102,-0.074121825,-0.006224717,-0.022346696,0.0011092453,-0.0571552,-0.01039324,0.06863641,-0.037943758,0.07749086,-0.0139674675,-0.02770064,0.045393452,0.012252075,0.059662968,0.049614545,0.03701894,-0.10122733,-0.026496476,0.049976796,-0.050461367,-0.15035799,-0.018023781,0.05030052,-0.034771435,-0.039818894,-0.0016064378,-0.060219087,0.015120451,-0.051238805,0.028026924,-0.0347633,-0.02863682,0.045792688,-0.044407584,-0.06268152,0.1827958,0.000773096,0.022632468,0.01284105,-0.09022756,0.040029883,0.022312436,-0.057662535,-0.06928551,0.023894755,-0.08743321,0.033581667,0.0207428,0.09467151,0.013122118,-0.051288933,0.024264691,-0.0039402824,-0.045008898,0.05810609,0.007208081,0.06119125,-0.021589538,-0.09797877,0.0008527501,-0.069297954,0.012653336,-0.066233866,-0.078393504,-0.09457007,0.031064076,-0.020502731,0.036257014,-0.0063397335,-0.05952572,0.015280367,0.045811288,-0.038635496,0.043383684,0.05321532,-0.014669584,0.027219066,0.004224617,0.028080959,-0.08871109,-0.012558058,0.044259463,-0.05937661,1.1592453e-33,0.033893887,-0.004658434,0.06484009,0.025824184,-0.06355129,0.030358722,-0.032955185,0.12874535,0.024718618,-0.060650814,-0.022351295,-0.00090077514,-0.012976502,0.030734133,0.0023194887,0.051797338,0.009105441,-0.015412005,0.023919834,-0.03790087,0.0077517233,-0.015946625,-0.10004655,0.06668095,0.0615867,0.06191265,-0.0068817353,0.08810599,0.039011683,0.04344619,0.020976959,0.075317726,-0.056365144,-0.007428352,0.020096242,0.036648933,-0.053064633,0.03747019,0.07977365,0.003268815,0.10968231,0.005633648,-0.01820172,0.010336759,-0.064077,0.03969202,-0.026186002,-0.016062476,0.060944952,-0.083409704,0.03632049,0.022196194,0.0074975775,-0.015548228,0.015259742,-0.02089323,-0.015244589,-0.0077365567,0.029924829,-0.002490555,0.0072994367,-0.06717167,-0.033247765,0.06788148,-0.0153359445,0.036718022,0.04413277,0.032689076,-0.008603186,0.06470198,0.036250163,0.06270011,0.030629233,0.022062715,-0.15468985,-0.005695357,-0.022699157,0.04778957,0.0818183,0.091220595,0.06458008,-0.012851611,-0.007180743,-0.09506609,0.025574198,-0.054839317,0.04580098,0.11611109,-0.0646505,-0.047287893,0.06627195,-0.061743546,0.0421008,-0.029698221,0.0067627756,-1.946046e-08,0.06675671,-0.022077946,0.05272499,0.012541036,0.025047336,-0.0028197465,0.0345195,0.03870322,0.028695196,-0.010150069,-0.042634044,0.0030866968,0.006249346,-0.019620419,0.0306744,0.025152218,-0.059011314,0.0114052305,0.019322835,-0.023396371,-0.08360512,-0.04254879,-0.13005061,-0.016740287,0.040349755,0.03346843,0.06485227,-0.024662178,0.0004174061,1.44810065e-05,0.016912736,-0.034563012,0.04371765,-0.03141662,-0.10132095,-0.015020709,-0.053279463,-0.04723967,-0.023027439,-0.042666618,-0.052591912,-0.044079285,-0.07884155,-0.03674576,0.044905026,0.00022894854,-0.03387636,-0.016193515,-0.03306119,-0.056962434,0.18890734,-0.018391464,0.027812473,-0.011830585,-0.1553994,0.060004737,0.08012217,0.00058262644,-0.06433721,-0.07017127,-0.02573889,-0.018213501,0.07208284,-0.003069664 +3.5.1.30,"The enzyme from Pseudomonas putida also acts on 4-aminobutanamide and, more slowly, on 6-aminohexanamide.",384,1.0,0.04914165,-0.11037076,-0.08819295,-0.0750667,0.0071476162,0.1121076,-0.10213803,0.075129636,0.04946071,0.013379052,0.08115818,-0.020411767,-0.036876436,0.098738424,-0.021158207,0.08519208,-0.04921681,-0.003768108,-0.04423861,0.009140008,0.025123917,0.047172543,-0.054912847,0.021390062,0.0052445084,0.01125715,0.02611462,-0.014567949,0.022917103,0.009636689,-0.040242754,-0.03296869,0.0027788056,-0.06986235,0.018907566,0.0152911255,-0.087641686,0.021321539,0.065954044,-0.006472521,0.05754839,-0.03357343,-0.03449916,-0.088410854,-0.031269524,-0.020928124,0.081278875,0.042310417,0.107226186,-0.02267367,-0.0419816,-0.06156597,0.0024541595,0.01654282,0.023775812,0.042675264,-0.03798203,-0.025009487,-0.02080032,0.035860833,-0.023538653,-0.003277459,0.06645338,0.06008994,0.04410414,0.031036822,0.00562179,-0.037045565,-0.014669703,-0.040281784,0.0030343882,-0.036396496,0.084376976,0.0019925332,0.0069860215,-0.06695493,-0.03477978,-0.021743625,0.038993552,-0.095184974,-0.030486722,-0.07641081,-0.013022022,0.069160335,-0.0031480535,0.0070366147,0.058163516,0.010444484,0.061352354,-0.026521867,0.015734248,0.007304112,-0.020574994,-0.10481212,-0.050074242,0.014733256,-0.060425702,0.07299228,0.041087575,-0.026154902,0.03831453,0.03827127,-0.089271024,-0.06657618,-0.01870157,0.021017056,0.056505743,0.06846499,-0.030897465,0.019533547,0.011316269,0.02121319,0.04153503,0.027128372,-0.043416098,0.038257755,0.09096706,-0.054706834,-0.088441074,-0.050648406,-0.0054579508,-0.059002306,0.06373423,0.065022625,0.020413166,0.04404065,-0.07531684,-4.7163235e-34,0.08094945,-0.011259005,0.054848,-0.065834366,0.060014885,0.0045491257,-0.039811894,0.015287467,0.007338714,-0.001593873,-0.035263192,-0.10939356,0.021989541,0.021647377,0.02766217,-0.038119324,0.003694323,-0.03338745,0.013280358,0.0020767718,0.060785986,0.061991394,-0.064187765,0.013583296,0.027633311,0.053464867,0.049406722,-0.0068935216,-0.022874845,-0.013545289,-0.027844876,0.021693552,-0.16460389,-0.047528386,0.05642056,-0.030533852,-0.05179296,0.019703105,-0.0005208556,0.072544776,0.060627796,0.024710149,-0.067239545,-0.00114029,0.11617053,-0.047127414,-0.052638076,0.17605701,0.04465494,0.10520494,0.026082372,-0.09154571,0.10138864,0.028550949,-0.020360846,-0.024730708,-0.049738996,0.039022483,0.044414684,0.06335281,0.0022531163,0.0012237539,-0.060164236,0.05808086,-0.0118392855,-0.0061657694,0.0039946726,-0.022575855,0.023063485,0.0035841083,-0.0638926,0.054174736,-0.02421737,0.03226125,-0.013662801,-0.10675824,-0.09372085,0.00085298816,0.040722325,-0.040822726,0.045766797,-0.049530543,0.041298952,-0.014143511,-0.065478444,0.00065736176,0.0030189028,-0.039176784,-0.10545635,-0.0069252797,0.1365457,-0.11770634,-0.03435563,0.04463403,0.008416485,-6.405422e-34,0.016677968,-0.07567555,0.07576903,0.0049099145,0.0024122426,0.034185354,-0.006976391,0.07553958,0.024664048,-0.03602404,0.06106585,0.04830569,0.009772009,-0.03460095,0.006828245,0.05841445,0.0011092302,-0.03137851,0.010272067,-0.077671155,-0.043661155,-0.0015724243,-0.048982274,0.024236748,0.10889512,0.09463333,0.03893243,0.08458053,0.010044204,0.06875113,-0.02229417,0.031306606,-0.072950415,0.0080443425,0.021774502,0.019074978,-0.013415737,0.024800336,0.041072816,-0.013722807,-0.0154359825,0.03913981,0.0033842335,0.067080066,-0.05735646,0.057981547,-0.11603708,-0.03338763,0.0076294583,-0.07945551,0.027744766,-0.073289454,0.029422507,0.025336722,0.008012653,0.00631949,0.010314436,-0.056714546,-0.051671006,-0.024760287,-0.03592456,-0.084815025,0.03472034,0.012771819,-0.044240676,-0.0012156703,-0.028013716,0.0402343,-0.016483253,-0.027349688,-0.01003604,-0.029583167,-0.013806902,0.061120253,-0.09294093,-0.012907657,-0.00079023745,-0.057113435,0.03735018,0.03717989,-0.028095987,-0.023842074,-0.022303,-0.073685944,0.014232966,-0.058370173,0.0495354,0.0814059,-0.030218992,0.042326886,-0.008911677,0.064938486,0.059186514,0.02654962,0.014060881,-2.7054261e-08,0.10464245,-0.08433604,0.079392515,-0.009890952,0.0014376874,0.010921926,-0.030540677,0.024288964,0.004135508,-0.10363733,-0.025492309,0.054424565,0.005996486,0.02029968,0.048394535,-0.023301816,-0.0875625,-0.05241203,-0.054345444,-0.052776083,-0.09910878,-0.03872575,-0.10147472,-0.019238262,0.021151584,-0.020833107,0.052808832,0.055109862,-0.010063981,0.007954954,-0.047512237,-0.03366029,-0.011942542,-0.017401831,-0.05739931,0.07444916,0.022741666,-0.045134023,-0.004444162,-0.0109307105,0.054998092,-0.09644018,-0.05495752,-0.02223517,0.08309989,-0.01012887,-0.022956727,-0.011241794,0.0076215114,-0.037762135,0.048224576,0.038694996,-0.008759444,0.01730306,-0.076101094,0.030419003,-0.020222813,-0.060332753,-0.0017742926,0.0029837766,-0.040766485,0.028048687,0.14977507,0.051685974 +3.5.1.32,Acts on various N-benzoylamino acids.,384,1.0,-0.060333315,-0.06762706,-0.06843701,-0.012652387,0.021815524,0.10727032,0.018648982,0.038809214,0.022636743,-0.08349207,0.00917161,-0.010378192,-0.052026913,0.039274182,-0.057808977,0.10927055,0.0059637995,-0.01722638,-0.016627235,0.0017989215,0.022641145,0.0069998135,0.016838983,-0.023005927,-0.027076498,0.051587,0.03634078,0.013347975,0.013563298,-0.094543256,0.09932346,-0.03081563,0.02764457,0.019068822,0.052644003,-0.06984422,-0.07980942,-0.07288479,0.0838881,0.046855178,0.046067446,-0.054564595,-0.033413947,-0.0321669,0.03726297,-0.030673144,0.056073375,0.02404943,0.0018618002,0.00580466,-0.03868724,-0.03153847,0.03079476,0.028351847,-0.09136784,0.028124426,-0.110171705,0.020281428,-0.029295433,0.03995948,0.06003697,-0.0010548396,0.0056655933,0.012994116,-0.012124819,0.035479445,0.024779236,-0.041086335,0.09626694,-0.042025898,-0.056247026,-0.025111208,0.021179432,-0.03722957,-0.017935546,-0.008744805,0.004143922,-0.03720596,-0.039802272,-0.05350459,-0.01747748,0.009400483,-0.035064496,0.11936713,0.04298312,-0.027789794,0.019395523,0.06654862,0.067901805,0.06605375,0.009818827,-0.013832359,0.030777369,0.03380825,-0.114054635,-0.022878526,0.030167162,0.0030464767,-0.0016287243,0.038420938,0.008198742,0.06330407,-0.049630806,-0.1155649,-0.0965689,0.075967826,0.013760667,-0.008727014,-0.035807554,-0.028413568,-0.027418444,-0.04232473,-0.005976103,0.0076139877,-0.070881434,-0.01586653,0.08121401,-0.019407488,-0.08774342,-0.012466773,0.02161793,-0.11419154,-0.0052256,-0.055662613,-0.050926127,0.092289284,-0.122775905,-1.714326e-33,0.09912539,-0.027992086,0.0125990035,0.007448815,0.03473848,0.014765424,-0.1261223,-0.08172633,0.017901113,-0.06996467,-0.0011360828,0.01986337,0.04725601,0.029571148,-0.016954372,0.05516642,-0.012330157,0.049763016,0.044593994,-0.04794478,0.018465796,0.07467727,-0.07771225,-0.08757403,-0.051640905,0.08208513,-0.045609795,0.018987788,-0.012460196,-0.0024968886,0.015421834,0.025453577,-0.10862349,0.05884072,0.0515993,0.058032516,-0.07982956,-0.03992223,0.021875845,-0.005861992,-0.043971587,0.029780801,-0.041904874,-0.0113421,0.032756586,-0.026651882,-0.09580348,0.06958231,0.06597138,0.036560312,0.008717166,-0.10304,0.08490331,0.013182802,0.049815565,0.024669409,-0.032601677,0.0025087981,0.024133042,-0.02651191,-0.04176037,-0.023974726,-0.07036016,-0.04174237,-0.011673218,-0.025837377,-0.06810519,0.052038092,0.0014966383,-0.023192784,-0.038073666,0.036714014,0.086471364,0.050277703,0.010870404,-0.04409458,-0.03211198,0.001134935,0.028960291,0.12005565,0.06085821,-0.06846467,0.06161661,-0.0911162,-0.06609915,0.03216421,0.007300207,-0.05227527,0.004450483,-0.008594741,0.028369762,-0.106382646,0.020044576,-0.017705163,-0.0012966531,-4.4133485e-34,0.11813515,-0.016071605,0.038978234,-0.020810995,0.024861064,-0.0077233124,-0.01623092,0.009827299,-0.02904755,0.031311322,0.021571528,-0.037874352,0.031049002,-0.013116484,0.05476601,-0.0066270204,0.10540291,0.07216288,-0.0085822,-0.0859853,-0.079793654,0.0726121,-0.02878771,0.07725214,0.0038578005,0.030638978,0.0006039265,-0.036791652,0.03456938,0.08832807,-0.015171163,0.011107647,-0.059378248,-0.065996714,0.11801309,0.05868722,0.0037992394,0.024991035,0.016372867,0.013329383,-0.013239098,-0.031720236,0.09797233,0.043421607,0.026087854,0.092905685,-0.08117856,-0.09535011,-0.07023409,-0.05695722,0.04756031,0.0065009263,-0.05882589,0.012289186,0.10746948,0.09657704,0.035202302,-0.050401848,-0.0032900108,-0.031599537,-0.025125714,-0.03470691,-0.044640318,-0.08661207,-0.08108335,0.016285356,-0.02853554,0.06476218,0.046493337,-0.002446933,0.043759074,0.037662875,0.09048392,0.043968298,-0.08549017,-0.049507517,-0.048039332,-0.08540286,-0.023244718,-0.052529637,0.021226104,-0.048807085,-0.009922533,-0.03585469,-0.0060703456,-0.042568635,0.012015256,0.034396045,-0.011216404,-0.016105209,0.012059908,0.008743934,-0.002058941,0.12751703,0.042251747,-1.8756351e-08,0.07035707,-0.07656527,0.015318618,-0.019937476,-0.05027883,0.036047067,-0.033849962,0.031689096,0.042408023,-0.042383995,0.053446677,0.04848306,0.054707874,0.08944307,0.010022852,-0.02369276,-0.034647197,-0.014292929,-0.049349356,0.037656195,-0.099565014,0.017189823,-0.011399663,-0.007512084,0.024939818,-0.039837964,0.06810915,0.0067914263,-0.021431241,-0.04144364,-0.026604878,0.0036994568,0.048161954,0.036483184,0.012302672,0.01980595,0.06603627,-0.06689472,-0.02444844,0.010955151,0.059273936,-0.057170272,-0.0822578,0.031183712,0.063466005,-0.02616866,-0.057308786,0.017508686,-0.09856926,0.014116479,0.060949214,-0.013056798,0.008037632,0.002797776,-0.06783605,0.004828736,0.038327686,0.007169202,0.055443007,-0.0008666751,-0.0055871448,0.05670339,0.10275241,0.021082183 +3.5.1.36,"In the reverse reaction, the product cyclizes non-enzymically to 2-hydroxy-N-methyl-5-oxo-L-proline.",384,0.99999994,-0.11600875,-0.026794802,-0.049842663,-0.009523734,0.071411826,-0.048936408,-0.017930353,0.088996276,-0.042840183,-0.0085042585,0.077608906,0.0534679,-0.05605922,-0.051080134,-0.08289127,0.1366089,-0.043307483,-0.022361767,-0.065400325,-0.051530693,0.057347935,-0.047261477,0.017432706,0.038178846,0.012150413,0.012509873,0.020462884,0.103871204,-0.04910712,-0.08947337,0.024632487,0.07112857,0.020111868,-0.06391181,0.0076547265,0.033420026,-0.02917291,0.001569297,0.043531734,0.013167111,0.04384447,-0.043998264,-0.06779653,-0.043251816,0.02868476,-0.03605594,-0.028329523,0.05959146,0.0646602,0.016475052,-0.025010204,-0.06744706,-0.11868951,0.018867327,-0.05969731,0.052855562,-0.04016525,-0.012739312,-0.006403653,0.01422976,0.024897149,0.026816618,-0.09932366,0.038407233,0.02086464,-0.00066357007,0.018967394,-0.071711205,-0.020679908,0.014031842,-0.012922605,-0.07550647,0.017717754,0.0070285667,-0.016162697,-0.0027956455,-0.030535229,-0.06936952,-0.011639734,-0.0054037333,0.0016561588,0.086408,0.03600658,0.07324076,0.023857888,0.010584235,-0.0016568002,0.019700132,0.08169968,0.012807506,-0.032722086,0.043223374,-0.013714287,0.074285015,-0.08989598,0.0474994,0.03698993,-0.010300993,0.01496724,0.01681626,0.011417946,0.033728678,0.02831709,-0.14313795,-0.03406698,0.04742312,0.0024420023,0.074963406,0.004979016,-0.032038957,-0.0158864,-0.027237302,0.01475052,0.021975987,-0.036181413,0.102468394,-0.004614895,0.011471599,-0.034451604,-0.07338201,0.013042826,0.028073588,-0.022947188,0.041555222,-0.07728457,0.080921605,-0.023392048,-1.1812672e-33,-0.023821238,0.016251214,0.042071514,0.052984886,0.017662091,0.04242974,-0.09048585,-0.034806404,-0.012136327,-0.0017956619,-0.047818143,-0.08321029,0.054335415,-0.044151016,-0.028819507,-0.07019307,0.004255428,0.056389093,-0.016545666,0.027726727,-0.024292264,0.097427234,-0.059610505,-0.027939627,-0.016050257,-0.004469278,0.045058325,-0.04606171,0.065811045,-0.009356477,-0.009008446,-0.08753194,-0.028918426,-0.018356955,0.019387832,0.051012944,-0.0020962644,-0.03771309,0.03576007,0.094365306,0.030301686,0.03358918,-0.02004639,0.012549621,0.036290314,-0.0813048,-0.06715894,0.090678945,-0.011336779,0.0303612,0.06740506,-0.0043229884,0.052489355,-0.019596934,-0.04394995,0.04562036,-0.03535352,0.045433454,0.038253993,0.032604426,0.008214157,0.035202008,-0.037794158,0.022679798,-0.028542474,-0.0058885682,-0.036614344,-0.023285937,-0.048470322,0.03081574,-0.06369009,0.02173392,0.121040575,0.03814957,0.05987749,-0.031544484,-0.007989464,0.016891386,0.06418531,0.043532867,-0.023010341,0.055500515,-0.01805372,-0.015552418,-0.028315842,-0.0044383816,0.010617377,-0.051531132,-0.050478432,0.049852647,0.11452786,-0.11359507,-0.015293317,0.02465746,-0.004972808,-9.569664e-35,0.03779761,-0.12327569,0.02969696,-0.04509975,-0.049569253,0.0132059585,-0.02585477,-0.06370493,0.009706888,0.022770073,0.06967638,0.030901423,0.044305947,-0.019862916,0.03606448,0.035100605,0.03031161,0.14100692,0.016752277,0.0027062753,0.06676302,0.013854407,0.061854497,0.036527146,0.04039633,0.010150634,0.068422176,0.06254694,0.13534778,0.045964237,0.015153587,-0.032599736,-0.052154597,-0.039580356,0.019567687,0.1352403,-0.075611785,-0.00579227,0.016174138,-0.040583182,-0.0722251,-0.008396353,-0.017432548,0.0011846969,-0.0013139062,0.053873815,-0.056779467,-0.011388754,0.01106247,-0.024884935,0.046697572,0.02527421,-0.054893743,0.02123299,-0.014896358,0.057299364,0.021716185,0.049237046,0.0024339426,-0.030180715,-0.032793254,-0.043409254,0.038076308,-0.04074817,0.01769826,0.108671285,0.01721097,0.0067806374,0.010898765,0.0020409937,0.06862697,0.094122544,-0.058491282,-0.034475822,-0.03644015,-0.022423198,-0.0036478983,-0.07788221,-0.078053266,-0.060373373,-0.007539566,-0.074189626,0.035832055,-0.046232976,-0.061407033,-0.085848294,0.019349517,0.12544762,0.015079596,0.032098204,0.046106532,-0.050931502,-0.07326628,0.03408055,0.14607885,-3.063092e-08,-0.0050645587,-0.10083411,0.0821495,-0.03238549,0.026770376,0.055523112,-0.002727192,-0.013511924,0.09474773,-0.059750635,-0.012333131,0.069774054,-0.0122319115,0.030953653,-0.01832685,0.033944223,-0.024677616,0.033443257,0.0016009135,-0.028883569,-0.08570864,-0.020391509,-0.03234802,-0.006246795,-0.05218443,-0.10407052,0.06967297,0.0392721,-0.023549559,-0.11880374,0.043225497,0.035777964,-0.036807723,-0.018011974,-0.021154603,0.0160956,0.017873263,0.036810443,-0.030989522,0.03251892,-0.06169737,-0.05783629,-0.0421685,0.02549703,0.008835067,-0.050284464,0.011930906,0.012418899,-0.020804303,0.022058709,0.050364606,-0.053089008,0.0266565,-0.1189298,-0.09344771,0.04446367,0.009756992,-7.3993644e-05,-0.022245271,0.005260241,-0.09452607,0.026459163,0.18282299,-0.036019757 +3.5.1.38,"The enzyme from the bacterium Achromobacter hydrolyses L-asparagine at 0.8 of the rate of L-glutamine; the D-isomers are also hydrolysed, but more slowly. cf. EC 3.5.1.2, glutaminase and EC 3.5.1.1, asparaginase.",384,1.0,-0.057830006,-0.10806913,-0.057161745,0.018991519,-0.018695844,0.03280679,-0.09893109,0.07965424,0.039094187,-0.02066566,0.07334346,-0.04512518,-0.023796024,0.047256295,-0.066684194,-0.023047004,0.024889482,-0.038458176,-0.11054905,-0.04396522,0.06856666,0.044174,-0.065158345,-0.06304855,0.121544324,-0.042086586,0.0066152243,-0.072789855,0.038135864,-0.109351896,-0.010930262,-0.11620849,0.058676094,-0.027905231,0.10490507,0.06126573,-0.009930672,-0.07138784,0.15805146,0.029996775,0.0104625365,0.016592603,-0.019285534,-0.010631171,-0.06522353,0.016647624,0.008131946,0.06012266,-0.0014394622,-0.026725922,-0.028133577,-0.045666035,-0.086428866,0.003987146,-0.07279926,-0.04936114,-0.07292568,-0.032182448,-0.015420794,0.00073949795,-0.056525268,0.04944703,0.012423546,-0.0031333815,0.009231167,-0.082520306,0.09897906,-0.083563454,0.049816124,0.032023508,-0.027372442,-0.024617651,0.044996556,0.047656365,-0.0027495075,-0.079373665,-0.027257673,-0.048911095,0.027274828,-0.046469856,0.059594642,-0.08459604,-0.0033167338,0.07820139,-0.051136926,-0.09151885,0.0074007707,0.034189176,0.05516179,0.0038474023,-0.0005547923,-0.022953777,-0.023855008,-0.07115237,-0.0071803806,0.03463593,0.046123184,0.0025882865,-0.0009736775,-0.049213096,-0.070702516,0.050421588,-0.06817566,-0.037430726,0.031334672,-0.014055639,0.007993315,0.053332098,0.06889115,0.014708212,-0.025195597,0.025002696,-0.024969473,0.005336535,-0.09338605,-0.04287072,0.076254874,-0.07998066,-0.061506297,-0.04230981,0.037155326,-0.055067126,0.039263558,0.06399286,0.004788378,0.097147815,-0.034220643,5.1921457e-34,0.041596502,-0.035720695,0.018621376,-0.10809558,-0.051858585,0.03605362,-0.10518334,0.042029437,0.03914506,-0.07535742,-0.13860247,-0.0717132,-0.008999523,0.036634997,0.0057460587,0.0024430933,-0.016170163,-0.0047043734,0.01406987,-0.002025658,0.039155226,0.06412123,-0.021335278,0.06200751,0.017861232,-0.0064610518,0.050037395,0.027908009,0.03352101,-0.011429468,0.028026918,-0.0834835,-0.10840168,0.017776,0.041366212,0.051883373,-0.064035505,-0.027495427,0.054078337,0.040775705,-0.017375013,0.02444803,0.03955597,-0.07268637,-0.016182572,-0.0006783898,-0.06892636,0.037912622,0.02428219,0.07039858,0.0096854875,0.017348107,0.05972321,-0.03656044,-0.022727551,-0.0005401869,-0.049889956,0.053943217,0.03736393,0.0872821,0.044149254,0.07364464,0.0016775717,-0.033619825,0.008708566,0.06164465,0.0028289908,0.03461512,0.074797064,0.031029053,-0.13003068,-0.06195431,0.067704566,0.030611277,0.042233538,-0.055302713,-0.011216597,0.019589573,0.036983132,-0.074085034,-0.00035010834,0.0067431,0.05234029,0.060300656,-0.0057114237,-0.047371197,-0.028705847,0.020912386,0.023683866,0.012361876,-0.0043039797,-0.038875125,-0.02811218,0.029603992,-0.020835927,-2.5596926e-33,0.08919757,-0.07063897,0.023197042,0.046478085,0.02076062,0.04446293,0.0042361207,0.09613849,-0.017921004,0.017333673,0.067703836,0.078816116,-0.03641419,-0.008540167,0.0072603505,0.037108153,0.004309659,0.04040158,-0.022363903,-0.0055219354,-0.030867454,0.022811616,0.048636314,0.03562056,0.061280727,0.009678532,-0.0012561409,0.018954223,0.0030386206,0.06262208,-0.0023284978,0.06447933,0.0040396964,-0.11999513,-0.08210136,0.04657153,-0.026216378,-0.015506731,-0.023635551,0.011066883,0.054127928,0.039200936,0.050673123,0.033152204,0.043344107,0.064386725,-0.049703695,-0.070792384,-0.062518075,-0.017092712,0.0096414955,-0.0050608586,0.012273962,0.004299079,0.0072138114,0.026481014,-0.022600085,0.030563308,-0.016915936,0.0023892822,-0.04715045,-0.055257563,0.049259253,-0.035999425,0.017578058,0.040219467,-0.00020922486,0.06285845,-0.016977895,0.0009312985,0.06573474,-0.040463723,0.042691626,0.034401454,-0.0026246896,-0.092463784,-0.036969334,-0.038090788,-0.0030175487,-0.05209869,0.027967794,0.015917532,-0.03544302,-0.01848841,-0.045200214,-0.022373972,0.028330563,0.07524952,0.003963181,0.081808396,-0.034326058,-0.029746804,0.0028044465,0.08386581,0.10572544,-3.64713e-08,0.048347667,-0.0046279645,0.083821855,-0.0076878374,0.06815173,0.1228954,-0.05531816,0.08367182,0.022926506,-0.020115044,0.003000895,0.04118911,-0.04911946,-0.023266735,-0.028905973,0.028917126,-0.107935086,0.025757313,-0.005512539,0.07763915,-0.09942436,0.032240883,-0.087896846,0.013367226,0.059798885,0.0046696463,0.04871462,0.0029058214,-0.025729463,-0.02232626,-0.0070043034,0.07403,0.02586405,-0.07258439,-0.099749915,-0.0108703,-0.037791807,-0.037233893,-0.0043303836,0.054784253,0.0027657344,0.042317517,-0.053603046,0.028403336,0.07087714,0.0020630995,0.016771285,0.0141430665,-0.038302258,0.0017739702,0.05155964,-0.046351478,-0.05226816,-0.058499027,-0.061336853,-0.012925191,-0.10107195,-0.11600748,-0.059440363,-0.021751111,0.023939213,-0.013436945,0.14027847,0.03729101 +3.5.1.39,"The enzyme hydrolyses N-monosubstituted and N,N-disubstituted amides, and there is some activity towards primary amides. It has little or no activity towards short-chain substrates.",384,0.99999994,0.014452808,-0.074283056,0.027960105,-0.032467723,0.075616,-0.0016067276,-0.117081426,0.042804435,0.02084127,-0.03287781,-0.016833885,0.0054167043,-0.012774873,0.061446328,-0.016327737,0.051518183,-0.033516236,-0.08494513,0.03326164,0.0032416796,-0.0171547,-0.01894183,0.014747272,0.016461978,-0.03139962,0.007329966,0.09669019,-0.0041330485,0.047438823,-0.0882534,-0.01876543,0.047958534,0.1037225,-0.03211702,0.019459637,0.15565817,0.023298187,-0.023470636,0.012121139,-0.0056810556,0.011424426,-0.018325407,0.047647938,-0.028294284,-0.0026459268,-0.0998475,0.012380857,-0.030861564,0.04103436,0.009186969,0.04314133,-0.11481708,0.027276538,0.07068771,-0.0047290116,0.05246403,-0.15138194,0.0038323721,-0.036456134,0.061566085,0.03253813,0.024951437,-0.025977496,-0.017474772,0.05803488,0.024224795,0.020245787,-0.010962985,-0.05699533,0.05378513,-0.094984904,-0.05606436,-0.012562325,-0.005337232,-0.0030680909,-0.09788524,-0.058741435,-0.0057793306,0.060476314,-0.053657837,0.0023035454,0.0026826814,0.015871705,0.10703322,0.03854867,-0.002313524,-0.045459136,0.00023143864,0.08190132,-0.03938044,-0.019059412,-0.052029017,0.0032433383,-0.004065824,-0.050171513,-0.010378345,-0.02411875,0.108359106,-0.044715997,0.016794229,0.052633464,0.08521523,-0.053535476,-0.063893326,-0.0466559,0.0464087,0.023459656,0.032719895,0.039179154,0.029617254,-0.04940838,0.032045137,0.011939023,0.0021577359,-0.07523474,0.007623663,-0.023459103,-0.065271266,-0.046731897,-0.031386275,0.0020430752,-0.0073663355,0.06607274,0.04413958,0.008118616,0.10970966,-0.016487854,-1.061616e-33,0.061710924,-0.05506014,0.03949111,-0.048610393,-0.0012700419,-0.033389296,-0.015965108,0.003615856,-0.009189341,-0.08878062,0.011507316,0.05573661,0.020434933,0.044975735,0.05168891,-0.12027096,0.12695618,0.05354885,0.025219452,-0.011198761,-0.024707839,0.06415881,-0.044025935,0.020274617,0.015184551,-0.0050390316,-0.002285843,0.047668792,0.05694179,-0.018965723,-0.06501875,-0.054322086,-0.06160234,0.034549326,0.041720446,0.04183625,-0.015831426,0.006403986,0.0035595756,0.03151609,-0.018997036,0.028165745,0.041846767,-0.08005799,-0.052012984,-0.011993414,-0.009547356,0.06522105,-0.025429169,0.003203612,0.09496893,-0.037952915,0.004497197,-0.00045795765,-0.041896075,0.08230261,-0.04759238,-0.02938584,0.0008612085,0.043580603,-0.06116542,-0.044225078,-0.04834373,0.023183724,-0.10029745,0.06245488,-0.07064234,-0.02302998,0.055862296,0.10991451,-0.042016745,0.08000783,0.018178595,0.10887313,0.09647459,-0.057916254,-0.012565543,-0.0029701614,0.041910626,0.058634557,0.015551705,0.032437343,-0.028166734,0.034138974,0.006360608,0.00203318,0.020481233,-0.029260654,-0.025140412,0.032701377,-0.047660843,-0.05934467,-0.016349746,0.032997116,0.052800756,-1.073722e-33,0.076537035,-0.06505542,0.0046946695,-0.034523603,-0.058620106,0.032053575,0.08428911,-0.0133252125,-0.023196837,-0.052740037,0.06104068,0.06069182,-0.021303156,-0.027774943,0.013921147,0.046873044,-0.03008469,0.027614042,0.036221016,-0.05140201,0.02689978,0.03048021,-0.027682822,-0.010603766,-0.006215356,0.0012793697,-0.022911869,0.10702187,0.03178986,0.051518247,-0.06295115,0.017123897,-0.009902725,-0.071941204,-0.017464722,0.12591025,-0.06340157,-0.0102587985,-0.06908627,-0.058119927,0.049255345,0.047023974,0.03879656,0.0903036,-0.020514885,0.046894398,-0.13640374,0.026867136,-0.050526876,-0.052769568,-0.020552462,-0.03966078,0.0038190456,0.026173232,0.024359908,0.091445975,-0.043801434,0.037476286,0.05517109,-0.048070967,-0.03356626,-0.041027498,-0.09344657,-0.0361113,0.013612588,-0.008654102,-0.088870235,0.015222578,0.0014196192,0.008755282,0.062349577,-0.0022168905,0.06297424,0.014196237,-0.037084028,0.0023554987,-0.07763601,-0.116938874,-0.011130917,-0.042041093,0.060624238,-0.01034171,-0.07584769,-0.1118563,-0.043909665,-0.0034605262,0.10637827,0.008272056,-0.033320617,0.054589294,0.03500025,-0.033236615,-0.032977585,0.108990945,-0.00048791783,-3.470931e-08,0.026144005,-0.07752186,0.05628239,-0.05489059,0.008039425,0.04206436,0.013171075,-0.018823843,0.018136062,-0.024983421,-0.021635126,0.019931328,-0.10535011,0.047051307,-0.00661361,0.01240134,0.05566577,-0.028238788,-0.098260455,-0.003624985,-0.0805421,0.060549207,-0.09616205,0.007577696,-0.022248156,-0.013115561,0.0845832,0.015610506,-0.04180551,-0.070811816,-0.004379022,0.11285826,-0.013270839,-0.013057816,-0.03797144,0.077905975,0.0077136336,0.00630756,-0.027496815,0.0024669543,-0.009528803,-0.055280887,-0.0120692,-0.016234476,-0.022783177,-0.0037380191,-0.032723557,0.0048584715,0.01501764,0.06648304,0.04895343,-0.06312561,0.01853984,-0.0668428,-0.07982272,0.005473632,-0.008040547,-0.038521137,-0.036474776,-0.06925142,0.0052173682,-0.039230816,0.1891734,0.012912704 +3.5.1.40,"Also acts on acetylagmatine, propanoylagmatine and bleomycin B2",384,1.0,-0.07019487,-0.017465778,-0.09557813,0.0056803976,0.022232724,0.053280685,-0.0021976721,0.048917882,0.0035871363,0.014288214,-0.013148414,0.010258433,0.0077428357,0.08754526,-0.0019402074,0.12763967,-0.02816765,0.01584526,0.053501826,-0.04883729,-0.056993887,0.0110310055,0.064658985,0.01682155,0.008602048,0.011905522,0.0026553117,0.08445373,-0.026733318,-0.031871237,-0.026479622,0.034063242,0.004286456,0.029359654,0.124324225,-0.042082325,-0.06274285,-0.007694803,0.04546234,0.0714469,0.049840517,-0.03907167,-0.05237806,0.03673224,0.008577625,0.029619733,-0.00084063434,0.043632284,0.04506468,0.08062383,-0.081325315,0.013395383,-0.027251866,0.08888336,0.052573074,0.0025079176,-0.08353409,0.027421385,0.047464143,0.021868544,-0.008401382,-0.075786225,-0.040154126,-0.02781954,-0.03534008,-0.011433355,0.0013189869,-0.057168998,0.09175423,0.054661836,0.021856843,-0.074376926,0.054182243,0.04553656,0.03897812,-0.06130545,-0.05038746,-0.08076301,-0.04321119,-0.040389042,-0.020769442,-0.058339838,0.010299981,0.045019068,0.041479226,-0.04168575,0.051537,0.0042423727,-0.02689385,0.0488143,0.04798835,-0.013868678,0.0031293144,-0.062201034,-0.030954355,-0.04710906,0.00079144543,0.0032183598,-0.013487464,-0.012124912,-0.0848406,-0.04658525,-0.060791682,0.0014845678,-0.0045340764,0.025268802,0.037710644,-0.03866973,-0.04743095,0.020366298,0.0155133065,0.004601319,-0.01882961,0.011315397,-0.022150015,0.094225675,0.073805735,-0.013859688,-0.03421515,0.0076603494,-0.016477356,-0.022194793,0.01639205,0.012538063,-0.047492526,0.057227254,-0.06319223,4.8773667e-33,0.01964656,0.041416414,-0.028842686,0.006438498,0.047065698,0.0051644756,-0.041461673,-0.043172713,0.015685644,-0.07365785,-0.032080464,-0.019089036,0.082821734,0.07835388,-0.052020915,-0.03845855,0.006436811,0.04283165,-0.0018856359,-0.084805496,0.037872564,0.121406995,-0.040978517,-0.00596322,-0.055828262,0.0017798827,-0.023013918,0.075644486,0.066614896,-0.028323235,0.013779176,-0.024494588,-0.014169069,0.014996392,0.015854027,0.11030474,-0.023390817,-0.030115679,0.01956911,0.06601708,-0.03879052,0.014435841,-0.08328855,-0.006206724,-0.013190558,-0.095632754,-0.057115924,0.07247486,0.05144462,0.008127436,0.0698063,-0.08648377,0.08608535,-0.07452849,-0.027341954,0.086421326,-0.023512436,-0.0702987,0.039123923,0.011998824,0.019140035,-0.046897303,0.031501513,-0.033220667,0.053603675,0.02331006,-0.07929583,-0.09269336,-0.082314625,-0.015813062,-0.034896646,-0.022054026,0.15818904,0.03010091,0.029073415,0.030907286,-0.035681263,0.03332309,-0.056809638,-0.011491225,-0.0005425081,-0.07634368,0.06713024,0.050395135,-0.049207676,-0.055938594,-0.031019107,-0.093178675,0.036708035,0.022963846,0.040001284,-0.058588896,-0.040209204,0.05470482,-0.005604708,-4.9119358e-33,0.04147707,-0.040422644,0.04628755,-0.019433234,-0.08492265,0.11299187,0.0316534,-0.012364215,0.031598423,0.008334518,0.0825553,-0.06216023,-0.06449535,-0.08157149,-0.05948974,-0.037893366,0.028950267,0.07180457,-0.027057724,0.007331473,-0.033441104,0.07941806,0.02858704,0.07069642,0.038125977,0.017251693,0.038969852,-0.018936327,-0.009776128,0.051227078,-0.041825913,-0.0036976512,-0.09723979,-0.08264731,0.03522094,0.08877638,-0.04909143,0.0064338706,-0.10099277,-0.04295502,0.009507504,-0.022709899,0.0053922413,0.076341145,0.06883504,-0.0062077893,0.03602953,0.011705251,-0.09939478,-0.06840831,-0.0027187436,-0.015717486,-0.0073290546,-0.014515379,0.031557597,0.043139987,-0.029887263,-0.08208351,0.04303167,-0.0065408656,0.018924857,-0.037313353,0.005190489,0.020824647,0.123320274,0.039799128,-0.070264794,0.039565183,0.13682717,-0.017594887,0.07065966,0.018252939,0.033063583,0.11069715,-0.053369448,0.016375985,-0.020605579,-0.090599045,-0.052456237,-0.011792594,-0.014230526,-0.01503321,-0.011684347,-0.01153618,-0.11699264,0.049965534,-0.015175964,0.029988,0.0062956605,0.016584339,0.0040132394,-0.0014134004,-0.07825194,0.08589511,-0.01253747,-2.6443665e-08,0.06972377,0.0060631656,0.098132975,-0.03493333,-0.053793635,-0.08105988,0.07789332,0.05959437,0.038081262,-0.06294335,-0.09828462,0.091763124,0.08476373,-0.039518207,-0.021699741,0.022670027,-0.0007480672,-0.00872285,-0.02869486,-0.014716599,-0.09378505,-0.027272388,0.0042317496,0.016969137,0.017063813,-0.025174536,0.033331893,0.13868791,0.0423568,-0.023493176,0.04652609,-0.074338324,-0.019457964,-0.07375941,-0.011856468,0.025632588,0.015849695,-0.028143799,0.022636466,0.040168017,-0.008751979,0.0027558368,-0.07233968,0.044522498,-0.048932064,-0.014432539,-0.012139039,-0.020895092,-0.01195855,-0.058330633,0.09139272,-0.0089718355,-0.015079368,-0.028002936,-0.12056423,0.006983958,-0.0059944,-0.024183074,0.08791712,-0.08379517,-0.049851477,0.016512409,0.09079251,0.036812898 +3.5.1.41,Hydrolyses the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.,384,1.0,-0.05717764,-0.13158858,-0.01490454,-0.042905096,0.08099418,0.022674229,0.024771784,0.04585305,0.011554375,0.054030064,0.058212854,0.07248376,-0.018170428,0.029173465,-0.14872812,-0.03749567,-0.04140555,-0.04808559,-0.025129206,0.009348751,0.052687015,0.018407535,0.020876916,-0.016173184,0.04811222,0.07049081,0.042330407,0.047594823,0.031833578,-0.041591138,0.009570204,0.010445839,-0.030244341,0.014603323,-0.0031595721,0.04820322,-0.008664056,-0.00270414,0.10041036,0.016794622,-0.020857664,0.010293675,-0.025045902,-0.028479556,0.05583464,-0.07461585,-0.06781768,0.033701066,0.053054873,0.05698983,0.089420214,0.020033173,0.05421329,0.023369323,-0.017617479,0.042412844,-0.08674937,-0.08448697,-0.030437231,0.1289792,0.024638988,0.0323399,-0.04563796,-0.09540436,-0.026795141,-0.013345085,0.037842706,-0.07010038,0.025882691,0.023251334,-0.014738867,0.015279452,-0.034713473,0.0077495924,0.012120911,-0.012652126,-0.06559683,-0.040298153,-0.043351922,-0.01974078,-0.0074005374,-0.020731702,0.033517532,0.1420896,0.0017976363,0.020352907,-0.013947761,0.021107435,0.07197895,0.024262724,-0.04639692,-0.03331667,0.049765017,-0.04886344,-0.022407627,-0.035218008,0.029843902,0.035366863,0.028145965,0.0028380153,0.025133267,-0.00023737115,-0.013216515,-0.07342233,0.015748953,0.040003628,0.10909511,0.018083898,0.053987842,-0.04864539,-0.038206857,0.050575577,0.010656477,-0.01517301,-0.11065431,0.03373393,-0.025655013,-0.043993678,-0.01612193,-0.025260868,0.028802384,0.06628739,-0.020221783,0.10900408,0.0023860538,0.016967762,0.03153544,2.1517407e-35,0.03129097,0.026026499,0.03918056,-0.039476898,-0.028160322,0.0018539501,-0.073397085,-0.014627839,0.053343434,-0.009873794,-0.09686756,-0.008771828,-0.020208664,0.0149168,-0.001091434,0.07233277,0.02858063,-0.046948146,0.08425486,-0.039335854,-0.017536025,0.09645323,-0.08572871,0.011451107,0.013517949,0.023835393,-0.0043601417,0.054030556,0.09199226,-0.0074239788,0.0031391284,0.010372705,-0.005116272,0.014781024,-0.01813745,0.06247814,-0.032873902,0.036422577,0.048448782,0.06589144,0.11779184,0.047809016,-0.023243181,-0.02631559,-0.04720187,0.008969458,-0.0141089,0.03274579,-0.023096923,0.0071142707,0.02448996,-0.04809973,0.060485676,0.039339326,-0.052395463,0.008207538,-0.022784585,-0.06396258,0.0887294,0.09536986,-0.00481737,-0.05329393,-0.028687477,-0.018497176,0.010548138,0.0048433463,0.012644921,-0.024677118,0.03755856,-0.01804771,-0.059289396,-0.009070837,0.06680266,0.051693983,0.028168214,-0.025018658,-0.0666923,0.085900754,-0.0031561712,0.04780313,0.045194462,0.024628926,-0.08889719,0.023654116,-0.053788245,0.024419235,0.020142268,-0.092049874,0.027251698,-0.030161556,-0.035898246,-0.07247325,0.010297846,-0.037989687,-0.057448454,-1.2535753e-33,0.07712611,-0.07490987,0.03332413,0.02694363,-0.026880644,0.04014718,0.035890214,-0.0016839608,-0.013845898,-0.009496515,0.054283433,-0.016058685,-0.03202263,-0.0081202,-0.04871002,-0.0023043524,-0.055378582,0.086829,0.015286534,0.057700414,-0.056888446,-0.0041490695,0.052057885,0.032795083,0.06656468,0.027174896,0.015600212,-0.025068197,0.021298412,0.054152243,-0.019195886,-0.030800521,0.0011338472,-0.06108367,0.008535452,0.036944877,-0.006007021,0.025182787,-0.0595623,-0.030010624,-0.013328887,0.010227084,0.036524758,0.022759652,0.019341055,0.058050252,-0.03296026,-0.100374505,-0.15928833,0.016785026,0.05247584,-0.021366823,-0.008757607,-0.013121966,0.07082228,0.074862346,0.011480278,0.02914241,0.047781132,0.016691066,0.0020164766,0.09022995,-0.021248452,0.0058279275,-0.0074712727,0.026357284,-0.06762944,0.07255075,0.0056735,-0.054460123,-0.036076933,-0.031950574,0.15045711,0.067649126,0.06471495,-0.040162574,-0.076611094,-0.06737337,-0.07245399,-0.0830455,-0.0014838006,-0.0314773,-0.08794701,-0.030927176,-0.08149444,0.026632704,0.033252627,0.115684375,-0.061177455,0.052552268,0.011409949,-0.025660643,-0.07163768,0.082442045,0.06896831,-2.2041556e-08,0.062986895,-0.04345317,0.022986341,-0.06453494,-0.034937534,0.035361625,0.021264074,0.051907804,0.027034972,-0.01779224,0.03214751,0.07309105,-0.042125996,-0.00090116117,-0.115690246,0.064855255,-0.04013862,0.007781875,-0.009805002,0.041855842,-0.0916863,0.10219591,-0.050373327,-0.048722096,-0.034847956,-0.037627783,-0.051132265,0.073041394,-0.080470964,-0.06967783,0.052054595,0.068209924,-0.061999887,-0.15075728,0.0048113707,0.001730635,-0.024815222,-0.060514245,0.07500532,-0.030183412,-0.032725014,0.050051115,-0.07202939,-0.009420317,0.049483124,-0.07686497,-0.02934302,0.05827559,0.02169342,0.049211647,-0.032869577,-0.009345386,-0.053468592,-0.14662078,-0.060311217,-0.035440356,-0.011528668,-0.10173243,0.018960586,-0.06543564,-0.037425425,-0.065727636,0.062196597,0.032085676 +3.5.1.42,Also acts more slowly on beta-nicotinamide D-ribonucleoside.,384,0.99999994,0.04637369,-0.05362388,-0.03639884,-0.01089758,-0.001404571,-0.05274213,-0.057438362,0.050074134,0.13533755,0.012928337,0.0149973435,0.0903764,-0.057055198,0.085713245,-0.0028602316,-0.0070904107,0.025642453,0.10599545,-0.034395844,0.023000857,-0.02144352,0.0046052234,0.06413834,0.03272477,0.030815704,-0.006255725,-0.012848073,0.0063376767,0.006248871,-0.053402808,0.00051854784,0.028480906,-0.009344567,0.016236393,0.0027886776,0.032531586,-0.039266918,0.046863724,-0.005809071,0.02014781,0.0241037,0.026238361,0.0053775073,0.035784904,-0.0062332866,0.02600009,-0.07213124,0.067587554,0.06658839,0.034577806,-0.050558913,-0.07228817,-0.045315474,-0.06528206,0.009720657,0.07336451,-0.114322044,0.05111143,0.08722041,-0.008834267,-0.04306085,0.006900473,0.013400477,0.042495806,0.07676095,-0.010427185,0.04216217,-0.048334904,-0.030557927,0.0125962095,0.0568749,0.001305525,-0.037982102,0.013994671,0.022306353,-0.042523913,-0.050863,-0.055206534,0.06499628,-0.030710468,0.0066929646,-0.013271966,0.0017858249,0.040939935,-0.020899035,0.069090456,0.04267129,-0.0357693,-0.04940806,-0.03057992,0.08439422,0.05833556,-0.006710315,-0.00046024728,-0.06999112,-0.037607767,0.003475724,0.06991923,-0.11119806,-0.02568015,0.027616022,0.08087155,-0.0856185,-0.030859709,-0.037188344,0.055486098,0.065478615,0.020020247,-0.079200156,0.05677294,0.06264199,0.05571877,-0.04786358,0.019149208,-0.08675957,0.074622124,0.02784488,0.034212865,-0.025717054,-0.025144422,-0.015347538,-0.056994457,-0.0057499213,0.0031686751,-0.039184794,0.09450945,-0.0042166724,1.7138676e-33,0.04317022,-0.040452044,0.020735873,0.040933114,-0.017171102,0.017783608,-0.08377623,-0.049272444,-0.011717858,-0.020216055,-0.11767952,-0.123805024,0.02611989,0.033143062,-0.0016604133,-0.06384506,-0.03861735,0.008553426,-0.004971289,-0.017054053,0.05856983,0.03940255,-0.00731103,0.04420372,0.002306866,-0.013020077,-0.05296561,0.07704651,0.0019551027,-0.027009087,-0.002889318,0.032057025,-0.03361495,-0.01066908,-0.021221364,0.09065021,-0.025071083,-0.01058882,0.09227087,0.03555894,-0.002122072,-0.0052598086,-0.030704675,-0.04760803,0.026172753,-0.026780052,-0.046078805,0.0045690816,-0.042006914,0.044055935,0.03800806,-0.031994507,0.03702443,-0.021959703,0.029876653,0.015640588,0.023947518,-0.026529739,-0.009731108,0.09433197,-0.03303352,0.009518041,-0.0012406338,0.08935902,-0.015701244,0.026934572,-0.07893692,-0.09603505,-0.033637576,-0.018167775,0.011995612,-0.020113533,0.11427994,-0.09587076,-0.008366299,-0.04003599,-0.0106522115,-0.024508413,-0.004917913,-0.06859528,0.0030475236,-0.063397706,-0.026066333,0.01075664,0.03147777,-0.032906458,0.009330025,-0.100656874,-0.01527222,0.052406136,0.0041903616,-0.046962198,-0.05963085,0.02413262,0.083801344,-2.0526745e-33,0.040354054,-0.11642433,0.09061199,0.007704246,-0.027473234,0.05612976,0.013347495,-0.056169547,0.038523845,-0.072274946,0.06602987,0.0031179509,-0.10821111,-0.03424693,-0.06272985,0.053963903,0.05954816,-0.019663367,0.003931399,0.03387577,-0.035795316,0.10410052,0.01308918,0.044041686,0.033979617,-0.018067349,0.017622545,0.011292989,0.03652203,-0.037147652,-0.016358089,0.022384197,-0.06567416,-0.054186944,-0.023958115,0.11183209,0.01516492,-0.0038616625,-0.007961107,-0.04599309,-0.04885699,0.024690917,0.014813403,0.00024836903,0.050640203,0.033037387,-0.0131851565,-0.080218054,-0.063985914,0.025695214,0.042668495,-0.0567104,0.010805181,0.16625497,0.05043799,0.021067685,-0.0031891826,0.00084068294,-0.0063731545,0.01570818,-0.031098522,-0.038288064,-0.04630017,-0.06743882,0.0977448,0.018542869,-0.047843087,0.078536384,0.13228807,-0.049637187,0.034907553,-0.0050213253,-0.0351245,0.083428085,-0.058387022,-0.09661354,-0.023379369,-0.047516856,0.002591203,-0.017221192,-0.11976478,0.046477765,-0.06317805,-0.046504043,-0.027153675,-0.041628923,-0.008290021,0.032563016,-0.06347116,0.07863008,0.033268556,-0.041910067,0.07714741,0.061355576,0.025612216,-2.1193733e-08,0.066968165,-0.041456424,0.010226008,-0.06377885,0.05191217,-0.054777253,0.066086285,0.09472084,-0.007865296,-0.0747731,-0.024444023,0.13987792,0.07852963,0.023119517,0.071629606,0.058727067,-0.09560986,-0.057001628,-0.025112752,-0.028337408,-0.058153927,0.027587587,-0.030637413,-0.0131545,-0.09134679,-0.022934822,0.07889508,0.047970857,0.020003434,-0.013318083,0.025506333,-0.008478088,0.045955844,-0.10755433,0.005625205,0.02896645,0.026589356,0.02137785,0.069592446,0.048241414,-0.064260095,-0.08377375,-0.019828739,0.033787638,-0.054004747,-0.08079008,0.012039692,0.0333532,0.013302847,0.007065145,0.05834907,0.044994604,-0.049585167,-0.10909008,-0.07654957,0.01607642,-0.049029447,-0.010271371,0.102877356,-0.033334874,0.019761028,-0.09800558,0.041751146,0.0021015434 +3.5.1.43,"Specific for the hydrolysis of the gamma-amide of glutamine substituted at the alpha-amino group, e.g., glycyl-L-glutamine, N-acetyl-L-glutamine and L-leucylglycyl-L-glutamine.",384,1.0,-0.02240277,-0.078643374,-0.004264661,-0.041606154,0.04484128,0.036528386,0.03503622,0.052807827,0.007643769,-0.0074087926,0.028995087,0.019816346,0.014118005,0.032492157,-0.046997365,-0.0014765591,-0.0066844276,-0.06330666,-0.05347908,-0.02456965,-0.01125401,0.058608007,-0.049413428,0.010065908,0.01630207,0.027186766,0.058785044,-0.026618142,0.026268236,-0.0024579265,0.007179614,-0.0601472,0.04191012,-0.021546822,0.07063226,0.051963966,-0.075058006,-0.044769336,0.100205466,0.02878849,-0.042347006,0.013424534,-0.018965079,-0.045122858,-0.00028871655,-0.03735184,0.017221695,-0.014576348,0.0017087173,0.07456526,0.07587348,-0.06494005,-0.056321435,0.051206123,0.0331695,0.04650358,-0.12923194,-0.059500013,-0.020722348,0.10552183,-0.09209289,0.04188916,-0.040775366,-0.07283084,0.007975553,-0.006432523,0.061950207,-0.0849912,0.013554444,-0.019869283,-0.07873653,-0.059394605,0.0018775195,-0.021541877,-0.095900066,-0.07687205,-0.0248353,0.06550982,0.038465407,-0.08880096,0.061204597,-0.08340957,0.056815226,0.10377655,0.005641865,0.001053225,-0.01382174,0.04379426,0.16073714,-0.011732014,-6.53244e-05,-0.044923548,0.0027426218,-0.00037918228,-0.0023666427,-0.008732886,-0.014540343,-0.025850538,0.019466234,0.041268785,0.010669432,0.057328273,-0.06894357,-0.036533814,-0.03084391,0.033443447,0.012389133,0.06026729,0.003271039,-0.01685669,-0.0035774696,0.0011979296,-0.00590208,-0.018034026,-0.07316474,-0.012751113,0.10505855,-0.03331001,-0.04294377,-0.08557005,0.040657684,0.022464842,0.08489603,0.04060441,-0.02486995,0.073951036,-0.0077179624,1.9470517e-35,0.06469365,0.020169144,0.045791913,-0.097876534,-0.0106534865,0.04605681,-0.07201304,0.020578511,0.07629348,-0.072213285,-0.085565045,-0.030171473,-0.023695352,-0.017375404,-0.034767207,0.013851329,0.020859623,0.005786177,0.005838087,-0.031901907,-0.0010653435,0.115291186,0.006964441,0.032212097,-0.007969401,0.037270322,-0.021732002,0.044672575,0.054130755,-0.006671128,-0.0270419,-0.028227357,-0.09270197,0.061299257,0.007850957,0.058781985,-0.07143683,0.011057339,0.08113564,0.11152853,-0.0033119712,0.018707706,-0.0077328966,-0.0822513,-0.013924329,0.019376524,-0.013106179,0.06469393,-0.03197375,-0.029120522,-0.0014831849,-0.030067038,0.024930114,0.023027413,-0.07800215,0.021226278,-0.009075209,-0.007078941,0.037062157,0.105905615,-0.015856808,0.0364484,0.022639977,-0.013227585,-0.0054430086,-0.009211986,-0.05317794,-0.016970016,-0.006242399,0.012187815,-0.020621724,0.005536122,0.09486981,0.110929735,0.020471564,-0.08136661,-0.04663612,0.085355505,0.0062834187,0.0061919666,-0.0141573455,0.021482382,0.04710278,0.042559136,-0.024604196,-0.001262626,0.029285165,-0.0708685,-0.0071492186,-0.008894204,-0.06492662,-0.0027336464,-0.023526285,0.0165799,-0.01162817,-1.63643e-33,0.06609588,-0.07460086,-0.03989844,0.0025032489,-0.016377326,-0.029324675,0.015502702,-0.09939747,0.0016413145,0.031169022,0.011366802,0.05912587,-0.065896384,-0.032203414,0.006011675,-0.047425672,-0.054380998,0.07931347,-0.029591588,-0.045366973,0.0024122305,-0.007072946,0.04255929,-0.0376867,0.079594806,-0.0010386973,0.07834956,-0.0072062183,0.09508969,0.054140795,-0.06531641,-0.0076852557,0.04059091,-0.09970292,0.03367346,0.054601535,0.0066348454,0.061476957,-0.03584758,0.010088956,-0.0005329852,0.08223639,0.072290234,0.058754817,0.02027813,0.11486362,-0.031580944,-0.03768978,-0.14065836,-0.019839538,0.04559493,-0.06778086,0.00920648,0.013355109,-0.015559592,0.040185127,-0.010665378,-0.025253227,0.007248626,0.0071018506,-0.006669687,-0.023060791,-0.007530587,-0.02472386,0.03407094,0.008689527,-0.02121574,0.051344253,-0.022024954,-0.012650029,-0.017594276,-0.17295648,0.06481538,0.097695045,0.045715526,0.011174352,-0.047055777,-0.06646355,0.012181579,-0.09934679,0.056433495,0.009381216,-0.022829285,-0.028294088,-0.044590052,-0.025649792,0.029475367,0.16291869,0.03294601,-0.01602033,-0.031363204,0.008141111,-0.027403725,0.101123266,0.08336008,-3.584521e-08,0.00889412,-0.031973835,-0.03877835,0.019190772,0.034018233,0.03834665,0.014175783,0.04558844,0.04398076,-0.047913514,-0.035750084,0.067286454,-0.019004548,-0.005446469,-0.12697197,0.07855747,-0.04898884,0.028614547,-0.040830277,0.07882368,-0.10512157,0.013372993,-0.03305617,-0.06667002,-0.0046760845,-0.09702357,-0.03619615,0.036538865,-0.073949024,-0.066092454,0.008021076,0.062308207,0.026818115,-0.11209708,-0.04583168,0.060332865,0.015311904,-0.039342493,0.060751528,0.032072213,-0.07379451,-0.02286665,0.02358826,0.0019606822,0.066467114,0.009364926,-0.03036146,0.0077544497,-0.037557177,0.088342175,-0.001545182,-0.01599429,0.019284192,-0.09295021,-0.045795556,-0.031327553,-0.062390286,-0.06081497,0.059368417,-0.07390729,0.0011403938,0.010231881,0.12756582,0.029692473 +3.5.1.44,"Specific for the hydrolysis of the gamma-amide of glutamine substituted at the carboxyl position or both the alpha-amino and carboxyl positions, e.g., L-glutaminylglycine and L-phenylalanyl-L-glutaminylglycine.",384,1.0,-0.016030734,-0.09693878,-0.004545494,-0.0650968,-0.00085746305,0.05768912,0.00024251267,0.058381792,0.028942145,-0.006170863,0.05658987,0.037983015,0.020094808,0.052849147,-0.038129643,-0.016799904,-0.010929469,-0.023369431,-0.03078592,-0.022382732,0.002648248,0.05660169,-0.028224517,0.023200471,0.014183037,-0.009771029,0.07273647,-0.0136186015,0.019980557,-0.0018986155,0.015832549,-0.054486424,0.018683845,-0.021489026,0.05838447,0.03152965,-0.098764755,-0.06287325,0.12370025,0.0054751975,-0.050860174,-0.00038437915,0.0031061852,-0.045965478,-0.014751342,-0.043890458,0.030608213,-0.016759442,-0.027785158,0.031087965,0.08181191,-0.065379955,-0.06773027,0.045750745,0.0052912016,0.04687076,-0.11412947,-0.06650596,-0.02220791,0.09696039,-0.09393583,0.05908996,-0.05147076,-0.08525271,0.0017683269,-0.010430163,0.05379411,-0.07876961,0.013120097,-0.006844059,-0.07103953,-0.07008607,-0.0071095624,-0.021473315,-0.08470643,-0.09296867,-0.008158108,0.061745606,0.052654773,-0.07012621,0.055188388,-0.08999083,0.04332045,0.07283169,0.004786307,-0.006682677,-0.021081895,0.06900143,0.13690867,-0.020372665,0.017267931,-0.054121986,-0.011618831,0.002913426,-0.0054543964,-0.023367245,-0.025140634,-0.03576521,0.041481756,0.03316922,0.0153764235,0.027589777,-0.071534395,-0.008055785,0.00087057904,0.01133975,-0.0028516962,0.067305684,-0.0023920245,-0.021507397,-0.007112615,0.0067871506,0.0037925176,-0.027504263,-0.081255436,0.029513612,0.0921987,-0.032162257,-0.04317628,-0.09271951,0.03489274,-0.0087926155,0.07804317,0.048478607,-0.048802916,0.07079124,-0.01995306,1.0948157e-33,0.06783407,-0.013577439,0.045827348,-0.052642737,0.013833045,0.05278827,-0.10860342,0.022415431,0.076295264,-0.06831434,-0.08813362,-0.018805968,-0.036313016,-0.033804104,-0.03766094,-0.004201654,-0.04035868,0.03595925,-0.013244556,-0.014722493,-0.002448102,0.13087906,0.0025499559,0.087991126,0.020502208,0.043731317,-0.054642327,0.023147115,0.02816684,-0.0017432065,-0.031015715,-0.044121817,-0.09216358,0.05910213,0.017316291,0.04307547,-0.08593059,-0.036058802,0.085821636,0.10448714,0.028051658,-2.3732848e-05,0.0020237179,-0.07149113,0.0035140084,0.01909506,0.007163748,0.07877495,-0.060073223,0.006054521,0.010056087,0.0037441135,0.028823629,0.015627202,-0.07047133,0.034838207,-0.019932268,-0.013633925,0.042160496,0.098459266,-0.0020814748,0.04314116,0.035584006,-0.04989738,-0.00038509018,0.007032667,-0.10306616,-0.037274905,-0.0009209977,0.06999641,-0.0155802565,-0.010865748,0.077908345,0.09530953,0.03333249,-0.055462684,-0.038727336,0.07360133,-0.0074980943,-0.024861474,-0.038283594,0.060712013,0.04430374,0.03978251,-0.025251377,-0.013435156,0.029740637,-0.08635594,0.004533716,-0.022196854,-0.0831052,-0.0049269064,-0.028711494,0.018141147,0.009700371,-2.5292263e-33,0.053046755,-0.07892965,-0.038428858,0.022927593,0.007236335,-0.033588067,0.030194007,-0.102019876,0.029452635,0.009473661,-0.008945066,0.08904185,-0.08829131,-0.011168166,0.011071141,-0.020708896,-0.044652667,0.04666027,-0.055484086,-0.039120562,-0.016799951,0.011269974,0.05073491,-0.013395732,0.07835941,-0.019982353,0.062131654,-0.0057386737,0.08488087,0.039072726,-0.056080826,-0.0033993789,0.040413342,-0.0952111,0.0024867447,0.07366264,0.0053550573,0.0529685,-0.03886297,0.04836284,-0.006320252,0.06687463,0.03458442,0.06310663,0.028365836,0.10158773,-0.05016668,-0.02080591,-0.11317482,-0.039931893,0.025882548,-0.040107463,0.0074061356,0.0020352812,-0.02756964,0.04003175,-0.015580312,-0.04928873,0.0063454495,0.0271456,0.003982699,-0.013925834,-0.0043186154,-0.03676733,-0.002797316,-0.024533097,-0.0024702866,0.05372999,0.021523189,-0.0321759,0.0069060945,-0.14824651,0.078654714,0.1055077,0.031377614,0.008242218,-0.013097538,-0.073716395,0.044138692,-0.094195575,0.02820775,0.005798485,0.0059017516,0.0048068245,-0.04074087,-0.03427148,-0.008417005,0.15521336,0.05201596,-0.021858148,-0.03910195,0.016352236,0.007258956,0.09163831,0.052839547,-3.5295944e-08,0.0026654496,-0.0049952995,-0.015423606,0.024047773,0.01382845,0.058793675,0.03582853,0.04083822,0.04137893,-0.0667569,-0.017827129,0.07058956,-0.0473008,-0.0074243993,-0.1015028,0.09314359,-0.062252834,0.041737568,-0.067070104,0.08680433,-0.09177151,0.052674774,-0.023931256,-0.049031075,-0.029503461,-0.09150549,-0.026900414,0.052883532,-0.073883146,-0.03348123,0.021885758,0.062072847,0.033173967,-0.10028517,-0.04825824,0.07025075,-0.0073628575,0.0050534713,0.040499333,0.045623116,-0.0424734,-0.05683726,0.024015088,0.0053757457,0.061593972,0.03641369,-0.041044638,0.01684417,-0.0142067,0.103213355,-0.012209674,0.02496397,-0.009832169,-0.037408404,-0.045335107,-0.045715075,-0.069396704,-0.062224656,0.04473615,-0.09937378,-0.011336638,0.050243743,0.1479124,0.014072606 +3.5.1.46,"The enzyme is involved in degradation of nylon-6 oligomers. It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2--20 by exo-type cleavage, removing residues sequentially from the N-terminus. Activity decreases with the increase of the polymerization number of the oligomer. cf. EC 3.5.1.117, 6-aminohexanoate-oligomer endohydrolase and EC 3.5.2.12, 6-aminohexanoate-cyclic-dimer hydrolase.",384,1.0,-0.0017371831,-0.046952337,0.026153853,-0.0049857046,0.06658729,0.006284474,-0.020347578,0.0022621194,0.04696026,0.04105652,-0.031799845,0.12529142,-0.050694175,0.03864952,-0.053528383,0.08269176,-0.10830705,0.004679635,-0.056712054,0.006486412,0.051996242,-0.0005574498,0.024169654,0.004697868,0.08078984,-0.045174107,0.03745064,-0.023287695,0.00063452445,-0.016244652,0.013785913,-0.00033593687,0.0016512207,-0.01448903,0.053339995,0.12102272,-0.032982133,-0.05735747,-0.061220545,0.023029665,0.07410025,-0.009953743,-0.051833738,-0.11900781,-0.04690678,-0.041183442,-0.06679829,0.04907383,0.030804811,0.036359135,0.0016205432,-0.08697609,-0.02246794,-0.048270218,0.085869476,0.00769247,-0.046496864,-0.063772574,-0.09896255,0.059959013,0.04198394,0.05370714,-0.01579571,0.026174828,0.032264415,-0.01252191,0.14089334,-0.01396013,-0.008485193,0.006587078,-0.11546799,-0.020766279,-0.00080220157,-0.0026554419,0.052768506,-0.06665762,-0.05846495,-0.05582158,0.03767743,-0.045008305,-0.012883873,-0.02461734,0.046681195,0.031644754,0.0067000445,0.066444136,0.044163056,0.00067418267,0.02180201,0.0055790334,-0.0006254353,-0.010644617,-0.03075228,-0.10256211,-0.0054960507,-0.0071195373,-0.0075592045,0.059303667,0.05637255,-0.013975313,0.008214426,-0.010853274,-0.025868658,-0.109522104,-0.004459734,0.043185674,0.024304908,0.112625055,0.024465574,0.032424457,-0.05237265,-0.025714867,0.109697856,-0.023698807,-0.07305806,0.113278165,-0.003973524,0.03478662,-0.02716034,0.021269126,0.004941118,0.047157854,0.09645782,0.06494892,-0.055453505,0.05834302,0.018596759,1.05622135e-33,-0.0133748,-0.02983782,0.029989656,-0.013899742,0.006891801,0.021812787,-0.019353453,0.031910714,-0.06814471,-0.03923554,0.0059488947,-0.03443095,0.0027821132,-0.012758508,0.107530266,0.010143145,0.025149949,0.05071534,0.032788157,0.012403917,0.0048514134,0.041214228,-0.03344102,0.03296635,0.0073828627,0.016619485,-0.01217055,0.05246326,-0.01785588,-0.026844041,0.069684096,0.0012031462,-0.14699163,0.016591186,0.021634055,0.0006575586,-0.060496107,0.026511896,-0.0043119327,0.026175953,0.055634912,0.0282728,-0.009621423,0.025225071,0.0024325873,-0.036540613,0.08936871,0.08975692,0.017716562,-0.006235943,0.04925577,0.03914292,0.063916594,-0.06485415,-0.04222981,0.014561627,0.0266183,-0.055256747,0.011909104,0.009405087,-0.0033123496,0.024481298,-0.043791637,-0.021793954,0.0011126192,-0.028168868,0.06585535,0.026500694,-0.0039680772,0.070521906,-0.062863894,0.0006820172,-0.007558344,0.061090577,0.026835749,-0.045983203,-0.069097035,-0.058473572,0.042020563,-0.049262382,0.07552131,0.037270006,0.0368368,-0.038350012,-0.050319344,-0.008170872,-0.0064557595,-0.038977772,0.007614111,0.10515381,0.079792686,-0.15943368,-0.11014125,0.03224925,0.017425159,-2.5985508e-33,0.086761594,-0.0061468165,0.0020827344,0.005917512,-0.08463372,-0.058512203,0.08341273,0.09659372,-0.025196522,-0.115127206,0.12864357,0.014587186,0.04239072,0.007644754,0.032571316,0.045444608,-0.071298294,0.06067902,0.022709796,-0.08761576,-0.051908754,-0.020175992,-0.02759537,-0.02253565,0.03776695,0.046623167,-0.016465835,0.013475676,0.040131755,0.015697906,-0.008394105,-0.063663185,-0.02555308,0.027289119,-0.025621802,0.072794735,-0.051854603,-0.02796714,-0.0016956803,-0.029286122,0.001281226,0.01826898,0.058750764,-0.02664298,0.014576733,0.003659138,-0.085524015,-0.016944993,-0.02422782,-0.020025164,0.026204567,0.04096507,-0.019097121,-0.0092318095,-9.056169e-05,0.024482908,0.042110063,-0.016165618,-0.06499698,0.023232473,-0.012535625,0.04853126,0.06744043,0.07427489,-0.014571494,0.05576102,-0.021875983,0.08729923,-0.04497567,-0.063834764,0.030098405,0.014341105,0.030979544,-0.022894686,-0.0007147752,-0.02359861,-0.07297503,0.043989174,-0.036905307,-0.0028932984,0.017022373,-0.029327473,-0.029324552,-0.009962321,-0.062124435,-0.0491903,0.13747633,0.06894357,-0.030278685,0.07158572,0.051789436,-0.0750754,-0.066686764,0.016930755,0.05169918,-3.9342016e-08,-0.026915465,-0.07610434,0.014791134,-0.10293362,0.037657343,-0.00094650075,0.012097611,0.036761086,0.0036696717,-0.04162385,0.0025168855,0.06362596,-0.055146817,0.04037662,-0.020624625,-0.07344157,-0.083224334,-0.015796639,-0.022070143,-0.07676125,-0.10831261,-0.021443445,-0.06779604,0.02255578,-0.009922239,-0.035769876,0.016366296,0.07370154,-0.010938381,-0.018681776,-0.037045095,0.023747694,-0.054412562,0.0033677688,-0.04637079,0.046630044,-0.032925155,-0.05112785,-0.06296586,0.04364562,0.020424435,-0.0399355,-0.031556148,-0.03445407,0.09290748,-0.019044083,0.038084336,0.002014102,-0.081145674,0.043758824,0.06327042,-0.042706307,-0.030678373,-0.06209285,-0.054859977,-0.06958235,-0.027670749,-0.028047653,-0.052091118,-0.03209221,-0.052171674,-0.040811986,0.2414374,-0.035261363 +3.5.1.48,It was initially thought that N1-acetylspermidine was the substrate for this deacetylase reaction [1] but this has since been disproved by Marchant et al. [3].,384,1.0,-0.08143316,-0.06663576,-0.08960243,0.043142,0.049641468,-0.009134898,0.007166649,-0.023520334,-0.04831242,-0.0302403,0.0016783124,-0.0057715503,-0.0682746,0.05318999,-0.06735222,0.0087376535,-0.02189872,-0.06606028,0.061892644,-0.0277345,-0.0017820155,0.0027950837,-0.008411707,-0.022982534,0.06974782,-0.0017134302,0.017292738,0.00027806588,-0.01763687,-0.079780765,0.034876615,-0.07524814,0.05127026,-0.03359686,0.09409633,-0.0051179235,-0.05009582,0.0058945287,0.009922796,0.053645965,0.057218943,0.031004453,-0.05627301,-0.009286851,-0.04064589,-0.04660972,-0.06998132,-0.023311546,-0.010027072,0.030210854,0.014663795,0.06597558,0.005581209,-0.023443243,0.05631454,0.010259819,-0.064524435,-0.008021659,-0.06041343,0.023847228,0.047376573,-0.014074612,-0.038680825,-0.067195065,0.040100485,0.03927105,0.09866763,-0.14784513,0.046357434,-0.004488711,-0.034368474,-0.08937242,-0.01637865,0.0262709,0.06488473,-0.033833493,0.006247789,-0.021495834,0.03654195,-0.0077301594,0.026722096,-0.0034682527,-0.00061597273,0.035475936,-0.05002006,0.030112615,-0.054365,-0.012471276,0.08598774,0.000119316064,-0.02323641,-0.026253918,-0.0065648765,-0.046003964,-0.0035081266,-0.03921826,0.0009853396,0.030363426,-0.013902985,-0.023315342,-0.016343454,0.056960057,-0.049153052,-0.08461761,-0.10620942,0.056653153,0.080784254,0.07445378,-0.033917278,0.060684174,-0.012080412,-0.005473776,0.057601463,0.04604437,-0.050550878,0.068552546,0.030298796,-0.060030438,-0.0021024852,-0.02804647,0.030609595,-0.06124184,0.025293173,0.088517785,-0.05546842,0.07310283,-0.05481118,9.736085e-34,0.009414394,0.03442276,-0.0049755606,-0.029902427,0.051943786,-0.01787541,-0.061970007,-0.0060206736,0.05518967,-0.16608727,0.010647438,-0.045789078,0.009973057,0.01944668,-0.07585731,-0.042943228,0.008442512,0.06465808,0.07145869,0.03650927,-0.017414268,0.09386696,-0.045655437,-0.050842155,-0.045528475,0.006426938,-0.116957575,0.03146049,0.067700036,-0.028047875,0.00743668,-0.018300481,-0.08329593,-0.00017327673,0.05950782,0.0015173268,-0.023793956,-0.0074000033,0.065154284,0.0817837,-0.020421263,0.092352904,0.029483745,-0.028887624,-0.009571364,-0.041080516,-0.12553562,0.06967258,-0.040115323,0.014254361,0.05930191,-0.04030095,0.08826199,-0.045522127,0.045511767,0.050515644,-0.018972613,0.009153986,0.07105571,0.030592335,-0.002532105,0.019860417,0.009168358,-0.028201498,-0.008032549,0.01687071,-0.07027356,0.0008675626,-0.012606687,0.010860556,-0.04479515,0.03672468,0.05993612,0.017833157,0.051257595,-0.049891494,-0.057969853,0.097851954,0.022286417,-0.021131247,0.037830323,-0.011086096,-0.004549284,-0.04173653,-0.06643423,-0.0038580908,-0.0004918561,-0.038536754,-0.04977228,0.06971466,0.028453283,-0.030425504,-0.04986611,-0.028263781,0.041677658,-3.6112773e-33,0.099634394,-0.11562459,0.05242147,-0.055699214,-0.08249652,0.072783574,0.032032248,-0.070646405,-0.0064582364,0.0036675017,0.09288363,-0.01016812,-0.011484035,-0.04006133,-0.026310466,-0.017186224,0.009310324,0.086050294,0.018370429,-0.02979814,0.004803412,0.051727213,-0.041676838,0.04618372,0.053297065,-0.001365494,-0.01120251,0.042981587,0.044139218,0.0038207213,-0.04911731,0.0076413294,-0.0021939662,-0.07450154,0.0199345,0.11164245,-0.0030215904,0.016798018,-0.10899222,-0.06423436,0.0027437655,0.034917478,-0.02198424,0.09751673,-0.00616604,0.029806212,-0.02992269,0.004214081,-0.024006255,-0.0060529104,-0.00708787,0.056510493,-0.0805912,-0.00431544,-0.020671098,0.13177368,0.068646416,0.0398104,0.028555753,0.0034465585,-0.015196583,-0.006201248,-0.02965155,-0.058042493,0.09806786,0.03213252,-0.06726857,0.13705978,0.050960556,-0.043831956,0.047399536,0.004665812,0.07816266,0.056267016,-0.019245064,-0.04026132,-0.06751985,-0.07980063,0.0012275814,-0.012218162,-0.028744403,-0.029298512,-0.054416288,0.0069280686,-0.009849819,-0.062412873,0.045471106,0.06339636,-0.10702916,0.02220784,0.03659138,-0.12311345,-0.075770825,0.070188485,0.019728761,-3.732989e-08,0.081515916,-0.035090093,0.017427223,-0.018611128,-0.06972077,-0.0010803948,-0.021879394,-0.007512701,0.024558606,-0.11862433,-0.03734887,0.095878914,0.049318638,0.058931503,0.034148324,-0.008894811,-0.023529343,-0.0041164574,-0.030511022,0.0138841085,-0.05024341,0.0026323954,-0.12827608,-0.0037913038,-0.060613558,-0.03066173,0.03815038,0.10698314,0.03179378,-0.089393,-0.034174055,-0.023297261,0.010622206,-0.062163297,0.10871333,0.02460403,-0.011518585,-0.0508873,0.0296588,-0.04652578,-0.034826268,0.056576848,-0.048646487,0.04617631,0.010871173,0.029781267,-0.03997045,0.005731632,-0.041760463,0.041597445,0.019944254,0.0024756214,0.01624729,-0.068763636,-0.045868047,-0.0072969864,-0.038704317,-0.02963659,-0.0016092729,0.05457091,0.06664828,0.0397167,0.17083044,0.03493133 +3.5.1.49,"Also acts, more slowly, on acetamide, propanamide and butanamide.",384,1.0,0.03396475,-0.14761603,-0.0733555,0.008371475,0.03098459,-0.03426542,-0.059922833,0.07315761,0.063454,0.007904456,0.07629979,0.04459494,-0.015918124,0.072970316,0.030317605,0.011748755,0.044723194,-0.0014893584,-0.020160988,0.035409894,0.033218034,-0.015133906,-0.009653304,0.0069557303,-0.041130524,0.08442798,0.028999196,0.022285497,0.06263494,-0.11263544,0.0382771,0.041994724,-0.004270607,-0.034642905,-0.023206966,0.025099078,-0.11874391,0.049522225,0.020393077,-0.015282359,0.04386128,-0.03796653,-0.024087444,-0.009653003,0.062782615,-0.06437844,0.006593073,-0.017592028,0.061954975,0.03077296,-0.029581146,-0.06319009,-0.047289558,0.03874188,-0.04390657,-0.047031283,-0.13547093,0.011755778,0.028931698,-0.0026209918,-0.09362532,0.03032664,-3.5839093e-05,0.037401177,0.03896604,0.029546287,0.070532724,-0.092202574,0.0013641112,-0.0049946974,0.010331406,-0.007837109,0.07050625,0.06854428,0.016377496,-0.11777171,-0.0021546134,-0.03857027,0.013906658,-0.0013858195,-0.05117708,-0.04289163,-0.03368578,0.038076214,0.01743006,0.069595814,0.039462727,-0.054667406,-0.0009984841,-0.035613663,0.06677601,0.051088206,-0.001713576,-0.021388216,-0.012300806,-0.035266273,-0.0319429,0.025704,-0.0344324,-0.033249386,-0.022218019,0.04817173,-0.14809144,-0.02000024,-0.04175993,-0.0041691824,0.09211003,-0.022044936,-0.082153924,0.11708987,-0.01222506,0.0001775104,0.018098326,0.019478062,-0.064491585,0.024438575,0.015051082,0.04203802,-0.05266828,-0.04559728,0.0029728636,-0.04006102,-0.0132147325,0.010133268,0.010242713,0.08671293,-0.0040389574,-1.7831795e-36,0.007975792,-0.03149485,0.017609183,-0.02294748,0.0061963783,-0.02789492,-0.060958426,-0.060761664,0.01610872,-0.07635171,-0.038974643,-0.08361091,0.00028007833,0.045316022,-0.007876668,-0.095627405,0.0066440534,0.024453938,0.013152686,-0.07233696,-0.015087283,0.071510054,-0.05508056,0.034584783,-0.0119652385,0.05272737,0.019119222,0.07918191,-0.032867074,-0.030542895,0.008457329,0.002938643,-0.10950147,0.026634252,0.045745358,0.12813756,-0.050114434,0.0001663272,0.043299094,-0.017556744,-0.07144161,0.047064845,-0.08045155,-0.031137984,0.05702263,-0.045466416,-0.08085527,0.104741015,-0.026221491,0.03353048,0.069703914,-0.028628623,0.099781826,0.017232526,-0.021691745,0.064869925,0.039261196,-0.04834177,0.0007376903,0.12119949,-0.047449656,0.022685612,-0.012405155,0.032837804,-0.041525368,0.09431267,-0.115787394,-0.021430433,-0.00738403,-0.0031589044,-0.007565223,0.019850563,0.09849176,0.007941631,0.016553968,-0.008906964,-0.036450706,-0.018380024,-0.009235778,-0.03064159,0.0006710086,-0.10385954,0.030002682,0.04410704,-0.041900158,-0.02369243,-0.014618194,-0.084144026,-0.030093417,0.019079799,0.06469981,-0.0789977,-0.01586087,-0.0018588097,0.009981793,-1.6405506e-33,0.011575051,-0.058519393,0.039242044,0.064401485,-0.00067408127,0.060872473,0.032817677,0.012978672,0.029546717,-0.047990154,0.066739455,0.013369991,-0.09185557,-0.066221885,-0.026205704,0.09189863,0.07629501,0.065882556,0.035144456,-0.06076798,-0.009691838,0.101337664,0.02898856,0.042503797,0.045613207,0.024679134,0.033190407,0.0046175397,0.014014353,0.0041055675,-0.004054477,-0.005154131,-0.099768855,-0.090128124,-0.027398251,0.040317528,0.0024476636,-0.018933604,-0.08569634,-0.08132364,-0.050727416,-0.0072723827,0.095612645,0.062752776,0.026253128,0.03425512,0.014430372,-0.036771968,-0.07845186,0.021888888,0.035092942,-0.031832665,-0.012303554,0.040593434,0.10200904,0.031145286,0.034058537,-0.080869414,-0.02882678,-0.018581413,0.031536493,0.008717591,-0.03390171,-0.029952878,0.05570245,-0.04961646,-0.017873665,0.0017851191,0.09707415,-0.03156144,0.06895912,-0.03553706,0.004697817,0.05357667,-0.08321224,-0.054898158,0.061067574,-0.06420976,-0.0091769025,-0.010354783,-0.04876895,0.0036615857,-0.002922885,-0.016018454,-0.13309644,0.03710818,-0.05570254,-0.03335106,-0.014806507,0.10835466,-0.0069881994,0.03168991,0.043370046,0.042981282,0.023876317,-2.1095952e-08,0.051196184,-0.06456366,0.0965694,-0.028338777,-0.011153943,0.04799632,0.045091264,0.047661807,0.006718087,-0.073221125,0.023096312,0.12125318,0.09162687,0.0072189514,0.033077706,0.0075896145,0.0060412223,-0.0018283153,-0.051936682,-0.034098454,-0.119436115,-0.005370095,-0.014413396,-0.029424902,0.015205195,-0.03769864,0.022102466,0.0703984,-0.005842791,-0.023373272,-0.024591587,-0.02416045,0.06931463,-0.09655376,-0.0134743005,0.050690904,0.07938998,0.012686988,0.034610342,0.06287627,-0.064627394,-0.03872689,-0.054678466,0.042441312,0.016178388,-0.038730547,-0.016037364,-0.009135048,0.012098036,-0.041394953,0.045804985,0.037656084,-0.013846581,-0.04318854,-0.059455756,0.041626178,-0.06658976,-0.04689744,0.10764488,-0.03522199,0.045076706,-0.028417427,0.09147288,0.06489517 +3.5.1.50,"Also acts, more slowly, on other short-chain aliphatic amides. Different from EC 3.5.1.49 formamidase.",384,0.99999994,-0.026525265,-0.14013673,0.009619568,-0.013584836,0.06024045,-0.021931075,-0.030570362,0.04780063,0.08713147,0.032538977,0.09985005,-0.0031645542,-0.008165226,0.03333854,0.10120742,-0.02032377,-0.0145253865,-0.08039499,-0.045864556,0.00015292353,0.039961684,0.05658191,0.008787415,-0.007242451,-0.06551996,0.01613229,0.03553649,0.019834334,0.08378713,-0.16498476,0.025583154,0.05737896,0.05809649,-0.082908176,-0.02045699,0.07015733,-0.010406004,-0.048152905,-0.019879676,0.018272296,0.020761305,0.004691085,0.042994954,-0.06250053,-0.012704761,-0.06351778,-0.05246561,-0.0076252087,0.062028028,-0.053593494,-0.0231269,-0.11494672,-0.02887328,0.036091994,-0.030170811,-0.009445347,-0.16065527,0.026925689,-0.019007316,0.006627894,-0.049774595,0.0732325,0.008536413,-0.031198557,-0.0076432703,0.044382595,0.09979813,-0.11898242,-0.006353868,0.055841643,-0.07937794,-0.06927578,-0.00035030663,0.0331246,-0.012568992,-0.06769522,-0.0029793656,-0.07723765,-0.047807653,-0.0669508,-0.072007015,-0.010747791,-0.029167457,8.0310645e-05,-0.043728225,0.025271107,-0.005617589,-0.06845911,0.003398918,-0.03396262,0.08154319,-0.042331386,-0.019894436,0.00023299803,-0.007980589,-0.037878823,-0.007866816,0.10988218,-0.026476467,0.0061430684,0.034652036,0.07521321,-0.12290074,-0.049283773,-0.018708225,-0.008992667,0.053023864,-0.015505374,-0.04268916,0.07091125,-0.019578135,-0.09003829,0.008095624,-0.052155774,-0.09544625,0.05664104,-0.00980557,-0.034671538,-0.0010732554,-0.02876755,0.055691328,-0.04859871,0.04529385,0.01569862,-0.03996814,0.028362028,-0.059982385,-6.2435097e-34,0.014786062,-0.028555278,0.027940886,-0.058786288,-0.004222503,-0.031374488,-0.09982789,0.03682539,-0.012712035,-0.068397015,-0.06054201,-0.022596851,0.025016006,0.010756618,-0.006229491,-0.113587834,-0.010459668,0.06634849,-0.07571906,-0.045271844,0.017153293,0.07324892,0.015498451,0.0142345475,0.070174545,-0.0066891005,0.023648363,0.07277428,0.011171592,-0.012560065,0.0023781897,0.010541641,-0.09719386,0.056729034,0.00041476262,0.11695207,-0.01806811,-0.02042342,-0.040655807,-0.0014757018,-0.020813718,0.03703106,-0.031091567,-0.04645563,-0.005669306,-0.025908396,-0.02333886,0.0946945,0.072233304,0.0019417184,0.07140067,-0.037368692,0.05056443,0.071079195,-0.0036892733,0.031725902,-0.032124512,-0.005443781,0.007897385,0.076641954,0.006373408,-0.0109966155,-0.016876291,-0.0010068469,-0.07377276,0.10415546,-0.10384003,-0.0016027109,0.054416798,0.045036558,0.01629638,0.038644776,0.054342043,0.10235883,0.11258443,-0.071425796,-0.0880861,-0.03250239,0.047091432,0.047100592,-0.025887426,-0.05831068,-0.008172448,0.07121171,-0.018820992,0.0028537526,0.047637094,0.02176649,0.021585671,0.0381772,0.0059075993,-0.0519622,-0.00071303267,0.031138213,-0.016297653,-1.1860163e-33,0.048546582,-0.045720283,-0.055136863,0.062087003,-0.0040904703,0.042693444,0.0495496,0.099321775,0.0102931475,-0.057676796,0.10084141,0.022565307,-0.00970804,-0.048076928,0.040010206,0.00967894,0.00953774,-0.015401022,0.03815416,0.0031843344,0.0010546185,-0.0106612155,-0.012762815,0.008590873,0.021031156,0.0144859785,-0.003007643,0.03796051,0.029468281,0.001701094,-0.06369708,0.03139824,-0.10402832,-0.06736374,-0.070662454,0.039962463,-0.0474272,0.013382807,-0.06817531,-0.052279558,-0.025602141,0.05064578,0.13745676,0.08788798,0.034319874,0.052672613,-0.012578059,0.006124222,-0.0865833,-0.03849899,0.044126984,-0.021054791,0.015686426,0.021362336,0.017711801,0.06532505,-0.035271224,0.0016666786,-0.020736793,0.010347872,0.008171003,0.0021397853,-0.011830573,-0.03547218,0.11152571,-0.0171786,-0.035771538,-0.012284088,0.09865256,-0.020760354,0.049473614,-0.09171332,0.0026470667,0.011624449,-0.03067423,-0.062391598,0.020049756,-0.078227416,0.022389596,-0.06755424,0.037798,-0.022182193,-0.012219362,-0.039885797,-0.1066215,0.059644632,0.022929313,0.020455735,-0.01838614,0.08724819,-0.016922314,0.053910583,0.06034038,0.11609572,0.012480267,-2.92416e-08,0.044417284,-0.059099633,0.013175098,-0.04270779,0.0192875,0.048208516,0.00562847,0.03739437,0.020456254,-0.023570996,0.020433959,0.044259325,0.021767052,0.015926583,0.046165742,0.02104778,-0.031221412,0.057841823,-0.032875124,-0.008928272,-0.098398626,0.0054659713,-0.0776239,-0.05024639,-0.013161461,-0.0033943064,0.03582625,0.100244954,-0.062079094,-0.05452118,-0.028720662,0.07519125,0.016329048,-0.014253381,0.0049613225,0.044747986,-0.014541889,0.014184213,-0.0039234585,0.09913302,0.0021996067,-0.035499427,-0.032980993,0.0013450267,0.024792364,-0.01745551,-0.00020490486,0.005191816,0.026363526,-0.016890455,0.045230027,-0.037189092,0.025255386,-0.06403877,-0.07066578,0.01726576,-0.06563294,-0.08369772,0.09891885,0.0017467242,0.03345188,-0.038260125,0.12261906,0.088222496 +3.5.1.51,The enzyme also hydrolyses 4-aminobutanoyl-CoA to aminobutanoate and coenzyme A.,384,1.0,-0.0035541048,-0.06930954,-0.0086933775,-0.059470497,0.04174507,0.060325563,-0.09242005,0.042474758,0.00024520257,-0.0075164284,0.0135296425,-0.10071372,0.028247258,0.09436251,-0.091140576,0.02871274,-0.03583029,-0.016466297,-0.012835038,-0.056438092,0.050312042,0.020692986,-0.05247648,0.036591392,0.07678113,0.0022811822,0.04346333,-0.05060126,0.034247797,-0.026532302,-0.024658095,-0.048895862,0.026977502,-0.017197799,0.03033799,0.10821385,-0.02219252,-0.052935414,0.0351348,0.04475262,0.054783646,0.0055000735,-0.006013021,-0.07097178,-0.03968969,-0.039908227,0.042520147,-0.05846774,0.09829167,0.056856565,-0.028604418,-0.08078374,-0.07593138,-0.001666629,0.009990491,0.033522688,0.0015267258,0.0026345835,-0.028096383,0.071631156,0.021814639,0.01926099,-0.007984998,0.0031113345,0.04342441,0.029731026,0.0071191033,0.026229942,0.020507012,-0.047512125,-0.04796238,-0.039566252,-0.01747854,0.036777288,-0.03227182,-0.06094726,-0.02709944,-0.04112675,0.05505698,-0.025228051,-0.026988333,-0.021947248,-0.005997699,0.043090373,0.05895482,0.06365989,0.007591943,-0.065943144,0.07932134,-0.010219291,0.011450455,0.00012365931,0.0073193456,-0.032014955,-0.047085658,0.037170134,-0.019673212,0.0013721363,0.0037159815,-0.0093100285,0.014451509,0.06575622,-0.025110193,-0.055101503,-0.029040137,0.031384684,0.032453716,0.08236146,0.020655189,0.0036944447,-0.03147015,-0.009037867,0.06626023,0.019409025,-0.020598827,0.06485142,-0.0030726972,0.0061638895,-0.029422643,0.050949026,0.03578933,0.04511517,0.14206713,0.0426501,0.0014632669,0.0017651749,-0.0463249,2.4127016e-33,0.052039634,0.005249847,0.072747044,0.008325357,0.0027106062,-0.013517385,-0.06731052,0.07292795,0.007983814,-0.0415801,-0.045173973,-0.020129718,0.02152163,0.036145847,-0.005372425,-0.068632886,0.038852457,-0.026334092,0.0061944537,0.05344683,-0.025594657,0.04181407,-0.037926238,0.05813652,-0.024190005,-0.05856718,0.0059157475,0.0599108,0.07596847,0.022785855,-0.06018303,-0.04427837,-0.14759566,-0.054466456,0.0105379,-0.045160707,-0.025787134,-0.022638159,0.013493249,0.10313171,0.025251659,-0.052282766,-0.02621729,-0.042379547,0.07630881,-0.024497507,-0.032132108,0.09806941,0.031312205,0.0015036446,0.067419104,-0.03328287,0.06482976,-0.041757498,-0.07923783,0.007969064,-0.038305376,-0.030945841,0.032435175,0.07000255,-0.002764916,0.06187207,-0.024758315,0.027957601,-0.03539317,0.01663931,-0.026915135,-0.047605366,0.013222335,0.042324852,-0.050261777,0.0056461473,0.052630637,0.09913581,0.021973284,-0.121699005,-0.011297955,-0.013338351,0.050195806,-0.024947044,-0.01635534,0.023888292,0.048275776,-0.0021370247,-0.04751003,0.0053027286,0.064606234,-0.074928686,0.013146403,0.03375872,0.0867377,-0.05719437,-0.036129612,-0.016249506,-0.0067048892,-2.3146848e-33,0.09435403,-0.095593385,-0.052763727,-0.06763414,-0.09778258,0.02422732,0.08684265,-0.013812283,0.031211453,-0.030228797,0.10619712,0.014188331,-0.043756988,-0.055712517,0.019730778,0.08447003,0.010870853,-0.008064543,0.005964238,-0.050472822,0.0069837333,0.015321879,0.044087,-0.05184531,0.08793913,0.022623375,-0.02647798,0.039747838,0.039619684,0.087045096,-0.041132405,-0.044054884,-0.023152204,0.017433556,-0.09574635,0.07323291,-0.014306948,-0.019362632,-0.043806046,-0.028289478,-0.06292048,0.05414601,0.018191582,0.058250345,0.0027190049,0.060131583,-0.046997737,-0.051701795,-0.009686037,-0.048491254,0.036310416,-0.051608562,-0.020759206,0.010829442,-0.04680972,0.023578793,-0.0134790335,-0.0119238505,0.019169256,-0.035176568,-0.01318318,-0.05156574,0.028963074,-0.0120070195,0.049245473,0.05727583,-0.04453995,0.02792362,0.017036105,-0.024036743,0.06785309,-0.019801412,0.1319062,0.036433734,0.006034843,0.0011136666,-0.06343888,-0.040085107,-0.08666257,-0.103040785,-0.056270692,0.025102813,-0.036744773,-0.086638525,-0.094010144,-0.13305795,0.033258315,0.1360346,0.03773812,0.0676093,-0.042933173,0.006071901,-0.025113028,0.101420484,0.10284596,-2.5298341e-08,0.016873572,-0.044310775,0.030533383,-0.051569954,0.020815756,0.07894899,0.004912485,-0.06725105,0.046337456,-0.06714758,-0.093050405,0.047053836,-0.045454264,0.044575565,-0.023640765,0.031340126,-0.04005648,0.021422584,-0.026262028,0.021321114,-0.09911878,0.0628103,-0.12588975,-0.0015328106,-0.014154167,-0.032758027,0.0059656645,0.114137195,-0.028531985,0.023875779,-0.02614358,0.033304375,0.022238256,-0.10425847,-0.061859906,0.04009238,0.0048346044,0.013649162,-0.04272215,0.018666461,0.049997415,-0.055297457,-0.01419017,0.018966572,0.11432372,-0.04439998,-0.008838594,0.029674735,0.045162626,0.0046924665,0.046599858,0.0007076182,-0.0045026876,0.00023539347,-0.047169335,-0.024507383,-0.016131293,-0.1275127,-0.021766063,-0.07357597,-0.0762508,-0.022444794,0.22161604,-0.0031399871 +3.5.1.52,"Does not act on (GlcNAc)Asn, because it requires the presence of more than two amino-acid residues in the substrate [cf. EC 3.5.1.26, N4-(beta-N-acetylglucosaminyl)-L-asparaginase]. The plant enzyme was previously erroneously listed as EC 3.2.2.18.",384,0.99999994,-0.09367449,-0.11873658,-0.08751777,-0.0213693,0.026702765,0.0718754,-0.033410594,0.016715396,0.06107514,-0.03163971,0.10163869,0.00799661,-0.0697367,-0.011390201,-0.11102179,-0.035037577,-0.0051175575,-0.05361782,-0.03424613,-0.06321257,0.07068325,0.06094039,0.011661538,-0.020926565,0.022071697,-0.120620616,-0.04145619,-0.069325626,0.03884162,-0.11913569,0.0050590103,-0.03536234,0.05442028,0.08284426,0.04387516,0.055041447,-0.026458234,-0.112611346,0.06355674,0.057945147,0.058654018,-0.045078337,-0.033547092,-0.036712058,0.0075380234,-0.036367804,0.0057268357,-0.0032900558,0.03975853,-0.010705538,-0.009148027,-0.06524483,-0.02367696,-0.019337445,-0.028129395,0.035310525,-0.16405605,0.030922685,0.031065065,0.09071081,0.0538304,0.04683765,-0.037564043,-0.040662453,0.046240654,-0.0024005007,0.01080163,-0.06909018,0.043730352,0.029994112,0.048716754,-0.082718596,0.010706287,0.04541965,-0.02129454,0.012310688,-0.06867591,0.011473247,-0.019777596,-0.045589663,0.037430964,-0.034741797,0.024673948,0.037299085,-0.035866957,-0.035309892,-0.046627816,0.048520304,0.06709771,0.05594454,0.024813063,-0.050493646,0.026827957,0.022649953,-0.025647994,0.029287443,0.082032636,0.0005137439,-0.012406948,-0.005150355,-0.048287477,0.09675532,-0.031484134,-0.034247626,-0.0024917193,0.07019321,0.008741689,-0.045912884,0.05466399,-0.021848654,-0.050113395,0.013807496,-0.028456945,-0.05008275,-0.1147457,0.01594297,0.023086568,-0.11704359,-0.06372619,-0.033267967,0.0047869748,-0.003872031,-0.020410845,0.078696094,0.0002858683,0.07663476,-0.073229946,-1.5233871e-33,0.022412451,0.014798538,0.05532816,-0.07086569,0.020456752,0.009192164,-0.023938898,-0.023761457,0.0044160066,-0.11503574,-0.07073782,-0.0877066,-0.009882958,0.010427257,0.0028253128,0.027861807,0.007448251,-0.034344647,0.023871707,0.007102465,0.034102377,-0.023401244,-0.09464184,-0.011215244,-0.029093994,-0.0431165,0.006053379,0.029448092,0.083629765,-0.020507816,0.04713422,-0.07597029,-0.07541887,0.0379929,0.068062454,-0.0045633717,-0.016222324,-0.038763598,0.019412564,0.015232147,-0.014267238,0.052557413,0.037253335,0.007019529,0.0019429548,-0.02628754,-0.014660868,0.04646689,0.055477392,0.08424227,0.05911392,-0.017039685,0.1254974,0.014756313,0.051751718,0.07353009,-0.041764125,0.026688516,0.034285314,0.06621172,0.086875126,-0.05669303,-0.05283872,-0.015536679,0.026041586,0.11623686,-0.11494437,0.02639459,0.040761963,0.0056959935,-0.074969575,-0.07884512,0.04286322,0.04050508,0.06741694,0.0108665265,-0.08007473,0.08860959,-0.010070036,-0.013972393,0.004946779,0.0014914672,0.03122672,0.031896617,-0.058374573,0.042969253,0.101187706,-0.0394757,0.01127783,0.005940731,0.10456717,-0.058819275,-0.022446606,0.010616667,0.013902518,-2.1834922e-34,0.046919215,-0.02165387,0.009718519,0.032769386,-0.032810405,0.031201314,0.026139183,-0.043968797,-0.01450845,0.025086828,0.079743594,0.05516622,0.011643882,-0.018179461,0.031536717,0.012194683,-0.020183189,0.08798911,-0.023786286,0.007898952,-0.07200332,0.049296007,0.02189513,0.07417864,-0.0015280287,0.0074464437,0.049209457,0.042825546,-0.019737711,0.04138752,-0.0054075,0.013523326,-0.07042661,-0.042457838,-0.024705168,-0.011487848,-0.0067275953,-0.05164551,-0.04264842,-0.064066604,0.0114254635,0.024200032,-0.014180913,0.06742636,0.034347676,0.079967454,0.022489317,0.039720844,-0.059134487,-0.056171153,0.011708541,0.025254356,0.03565081,0.03687871,0.036145322,0.058541168,0.05979109,0.061371572,-0.014884447,-0.005868774,0.019062653,-0.03169635,-0.007875607,-0.07137005,0.04462939,-0.027481738,-0.060775876,0.07362992,0.053193558,0.004295345,-0.015366767,-0.014378594,0.073804565,0.021541744,-0.04683627,-0.045939144,-0.007902596,-0.06535208,-0.043078538,-0.051457163,-0.057285707,0.0037071258,-0.042260032,-0.06310981,0.005047837,-0.0046733473,0.085736305,0.09327057,-0.02021606,0.07283153,-0.01604911,-0.035648625,-0.02300063,0.06284078,0.09631394,-3.9203528e-08,0.017098978,0.06089271,0.039658204,-0.12178639,0.0557954,0.009304198,-0.0037381165,-0.0221493,0.023897106,0.028253566,-0.05265209,0.012744343,-0.018685585,0.012393639,-0.027164962,-0.053527016,-0.011502298,0.09273895,-0.024357835,0.050613243,-0.10959988,0.04204621,-0.15039904,0.024465045,0.038495805,-0.05946578,0.044441856,0.11018277,-0.019331645,-0.02739847,0.06910929,0.050128985,0.06757174,-0.053937525,-0.114475206,-0.023095395,-0.0061419504,-0.0024987676,0.06277786,0.031151362,-0.031700347,-0.044225216,0.0147230765,0.02592225,-0.061195597,0.04293822,0.0473259,0.0051191524,-0.032973558,0.07574756,0.062463235,-0.04504875,-0.03331509,-0.08702473,-0.035243258,-0.063963525,-0.049709808,-0.066807166,0.011677892,-0.027144937,-0.01808524,-0.060265817,0.078032725,0.00659692 +3.5.1.54,"Along with EC 3.5.2.15 (cyanuric acid amidohydrolase) and EC 3.5.1.84 (biuret amidohydrolase), this enzyme forms part of the cyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 6.3.4.6, urea carboxylase, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate. The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate [6].",384,1.0,-0.06550967,0.007163952,-0.066552706,-0.062072184,0.06251417,0.073553056,-0.061984215,0.057055365,0.026358671,-0.009754724,0.004235221,-0.051695228,-0.06807489,0.030705253,-0.033349153,0.02597309,-0.052474774,0.012686812,0.040266644,0.03100817,0.09895855,0.07403214,-0.07230773,0.00948736,0.020115051,-0.017255558,0.048823055,0.0074142264,-0.07205895,-0.081793986,-0.02186166,0.007059222,-0.0040533086,-0.10233632,0.08803198,0.063347675,-0.037673365,-0.06844092,0.080487214,0.045185667,0.020377198,0.03436562,-0.05437027,-0.052925643,-0.016870176,-0.013081003,0.058746915,0.019321173,0.01644708,-0.10977729,-0.04065633,-0.036194146,0.0524911,-0.017413583,-0.012189487,-0.061151125,-0.009166318,0.0073659713,-0.04568305,-0.008241488,-0.0005197137,-0.022448048,0.03636111,-0.02299975,-0.0052610985,-0.01929949,0.01537846,-0.054378964,0.063668735,-0.032719787,-0.15704657,-0.0803891,-0.012090829,0.044020355,-0.0057989554,-0.011387393,0.026395798,-0.06945324,0.022213496,-0.07374524,-0.02331678,-0.045493864,0.0014131026,0.0065846965,0.09570447,-0.10188233,-0.0062542,0.050924696,0.06949799,0.023486594,0.050310425,0.048970938,0.0393328,-0.017194435,-0.011258403,0.05492665,-0.017383093,0.010025658,0.010757975,-0.060679317,0.058148783,0.104009256,-0.026779924,-0.084979385,0.052620303,0.048215665,0.07209935,0.14344521,0.06761497,0.00609075,-0.057277426,-0.02281842,0.03540682,-0.04927341,-0.052731372,0.07363716,0.01938877,-0.078466706,-0.06227258,-0.021128437,0.02631681,-0.06181175,0.034283727,0.09586889,0.01889934,0.05202038,-0.13298012,1.2775967e-33,0.055297572,0.028836384,-0.100794695,-0.04607001,-0.019429272,-0.014728383,-0.041250583,-0.011245831,-0.017182,-0.11829005,-0.04072463,-0.020992314,0.03462306,-0.028658954,-0.094050206,-0.005618427,-0.047636367,0.043961197,0.03723848,0.014713812,-0.0018249442,0.022049105,-0.08530281,0.011416383,0.06743405,0.03331874,0.038773645,-0.0046498273,0.024806801,-0.012576243,0.034545243,-0.06936897,-0.12178674,0.02207683,0.07026661,-0.0133547755,-0.043749996,0.013563231,-0.019420076,0.07670398,-0.001975873,0.025081132,0.0570305,-0.025068901,0.09385844,-0.013100092,-0.061391156,0.12721801,-0.02026811,0.057564992,0.0057420395,-0.038535953,0.083727844,0.019825475,-0.09501088,-0.00212851,-0.052610036,-0.009074361,0.042997904,0.05029267,-0.0091025615,0.123336285,-0.05826363,0.030952377,-0.053121973,-0.006446523,-0.042027615,-0.016892884,0.053806253,0.07725867,-0.08533719,0.0008923247,0.08728834,0.06936466,0.050772384,-0.10815083,-0.054229494,-0.0032980628,0.028249186,0.06277768,-0.017359853,-0.028515084,0.07435516,-0.017163943,-0.08153043,-0.046835598,0.0020709836,0.0077428506,-0.013117181,-0.0039869654,0.092586584,-0.08074377,-0.038806412,0.06737201,-0.019399388,-1.7382898e-33,0.13670939,-0.03583836,0.06377834,-0.07887763,-0.025892453,0.052334648,0.06021802,-0.0044505154,-0.011607395,-0.06264637,0.103151366,-0.00465294,0.025023615,-0.019333508,0.042347234,-0.013642017,0.00278828,0.016600246,-0.011970322,0.009411861,-0.0011094231,0.039046932,-0.05282363,0.10245062,0.008934226,0.03219168,-0.0020599612,0.0011352332,0.06159012,0.03050386,0.015983652,0.045954093,-0.053877953,-0.04126865,0.005107954,0.06601962,-0.08779592,0.02278457,-0.036840215,0.0061360262,0.06619704,-0.018394874,-0.04709965,0.032923028,-0.00038541347,0.08386048,-0.029224705,0.01889848,-0.063419,-0.0312739,0.044654272,0.012961834,0.011564282,0.015478135,0.029673854,0.02706046,0.007505517,0.002654506,-0.02030566,0.046194807,-0.0010146061,0.0016921647,0.027426302,-0.05469545,-0.013139813,0.023682397,-0.03484102,0.028399961,0.010049357,0.043449264,0.021995168,0.04799784,0.018608551,-0.021203859,-0.071448065,0.0048106606,-0.0590479,-0.059358444,0.010590029,-0.04054772,0.05144535,0.0054294686,0.035557937,-0.010112321,-0.00605205,-0.025429366,-0.010124297,0.09971504,-0.020186087,-0.01449436,-0.029439317,-0.06728142,-0.035936,0.091352805,0.030214489,-4.5476423e-08,0.057348587,0.0011025775,0.069895886,-0.022150235,0.0057866103,0.032339443,0.03608757,0.043600783,0.020877063,-0.039753634,-0.016473375,0.030208368,-0.017636582,-0.0019897725,0.06052294,-0.0066937534,-0.0725507,0.04213258,-0.002187693,0.043066047,-0.06451892,-0.033253655,-0.18864365,0.049867086,0.037219364,-0.013963508,0.05640312,0.009826978,0.07260696,-0.057307605,0.0265717,0.011529851,-0.0029809957,0.055841744,-0.059252433,0.0016756979,-0.055141162,-0.054854598,-0.034773983,0.039117042,0.011152358,-0.046462048,-0.06403683,-0.015203939,0.067730114,-0.037821874,0.004096354,-0.007950668,-0.0048371973,-0.040401462,0.07155934,-0.044907145,0.005263115,-0.02347788,-0.0069804257,0.019863939,-0.018652886,-0.11184503,-0.060785785,0.014148728,0.049692895,-0.020624362,0.14539711,0.013569309 +3.5.1.55,Does not act on acyl derivates of other amino acids. Optimum chain length of acyl residue is 12 to 16.,384,1.0,-5.2641273e-05,-0.06910154,-0.05655384,-0.07505548,-0.010019972,0.026650233,-0.021320898,0.13822788,0.02284387,-0.037224874,0.14123313,0.0170351,-0.047920763,0.07078961,-0.029443005,0.050294984,-0.013346174,-0.030639675,-0.08259249,-0.081846245,0.016715627,0.02966825,-0.04720739,-0.013440322,-0.0028623363,-0.11959527,0.008802644,-0.014239714,0.013976738,-0.041607298,-0.008159092,-0.043759197,-0.004033121,-0.01166399,0.074512124,-0.006541803,-0.08073136,-0.08505078,0.1337337,0.03604493,0.029328724,0.06891417,0.017802982,-0.039283544,-0.049037077,-0.05116592,-0.009869982,0.06524829,0.0307437,0.042312264,-0.019756638,-0.0041497704,-0.026849294,0.032713406,-0.047237236,-0.016537158,-0.09193867,-0.05285362,-0.059514582,0.0144744525,-0.049679495,-0.06659987,-0.043187927,-0.02592314,-0.06698332,-0.019799672,0.06763053,-0.12053822,-0.0015974437,0.071219526,-0.021999067,-0.09410777,-0.035582006,0.057714827,0.07174343,-0.07169521,-0.02384961,-0.062954366,0.015275912,-0.09830983,-0.05392375,-0.02634897,0.06383603,0.008854309,0.037914876,-0.03404425,0.0011799955,0.0005629634,0.000671039,0.04571678,0.10756713,-0.020665715,-0.03512997,-0.04952615,0.006657554,-0.0068832864,0.0603506,-0.028053276,-0.06711922,0.0027016813,0.010469122,0.019236285,-0.09658026,-0.017871812,-0.10294252,0.04743171,0.019876195,0.027108546,-0.049577277,0.008591619,-0.017139843,-0.0014692198,0.06375587,-0.03077808,0.020935098,0.019118067,0.028296899,-0.03555315,-0.005288101,-0.019038081,0.016634177,0.020178525,0.03541079,0.1072675,-0.076818585,0.043699346,3.5015197e-05,1.2016963e-33,0.0040693,0.044048052,-0.011412601,-0.032649126,0.03497888,0.023645738,-0.061495997,0.029521298,0.012965656,-0.017307756,-0.060121126,-0.058817375,-0.00854876,-0.059508823,0.018332105,-0.018752687,0.08477693,0.045715343,0.05093743,0.035987902,-0.0074156085,0.01849856,0.04473044,0.0038565292,0.037612922,-0.0441441,-0.034005597,0.06720138,-0.03287478,0.007849649,-0.037421003,0.015725233,-0.07456437,0.050512083,0.016017508,0.036073618,-0.04224988,-0.011316482,0.051465966,0.037621275,0.10215778,0.08048176,0.05114267,-0.031115666,0.03925669,0.04075941,-0.012140375,0.08004275,-0.055890605,0.06667687,0.04948261,0.050997004,0.06116238,-0.010560416,-0.015097397,-0.0026484665,-0.10151151,-0.03137653,0.058101244,0.05443079,0.0058846185,0.033184055,0.001708907,-0.004087077,0.003818994,0.039767634,-0.104923956,-0.008030531,0.015036013,0.05016953,0.0034388192,-0.024201177,0.08362404,0.07296331,0.033157945,-0.09305264,-0.06365243,0.027557705,0.04734514,0.055745997,-0.034156602,0.007637084,0.04295654,-0.045517676,-0.016068278,-0.10207503,0.026375439,-0.008488673,-0.02066374,-0.005262145,0.057376415,-0.0066910754,0.023118148,0.0350701,0.028743336,-3.1468417e-33,0.10746264,-0.11479171,-0.0064395024,-0.016451739,-0.034892417,-0.0009947863,0.037719525,0.12511685,0.028109042,-0.026549224,0.11708336,0.04840364,-0.05090969,-0.07160172,0.070547365,0.052953575,-0.046269186,0.07050718,0.02791763,-0.023076024,-0.013693025,-0.038295507,-0.018849429,0.055566568,0.0378091,0.018895527,-0.06948318,-0.0022895052,-0.0059481147,0.047019076,-0.021521099,0.036914095,-0.06583647,-0.038616363,-0.019691387,-0.009798473,-0.057902772,0.025950966,0.030092735,0.082837,0.08751142,0.032080747,0.04536924,0.012808436,0.031351857,0.0024945177,-0.014822653,-0.05587672,-0.04918308,-0.14213638,0.043646354,-0.06618377,0.06663119,-0.085847326,0.049426682,0.08560245,0.024345988,-0.0068220664,0.07395935,-0.03744774,-0.03737148,0.026137333,-0.058117125,-0.050711196,-0.019109378,-0.017438304,-0.022098003,0.027593764,0.05514992,-0.03483563,-0.009270213,0.05504323,0.022871425,0.009315272,-0.07832438,-0.016781023,-0.0057594194,-0.06937903,0.004918758,-0.019510264,-0.059481747,-0.048506305,-0.031784065,-0.014271814,-0.023222318,-0.07305636,0.025015173,0.03822137,0.014021204,0.067008644,-0.0034058054,-0.02883627,0.09576529,0.034821026,0.0477812,-2.4358672e-08,0.06977113,0.007834565,0.034568533,0.02442804,-0.0012190973,0.087615535,0.0045308806,-0.008420406,-0.0067171254,-0.044317175,-0.0092192525,0.11668924,-0.01624964,0.1148448,-0.07951158,-0.013779249,-0.08929373,-0.01564277,-0.014349819,-0.013384471,-0.1399909,0.08165132,-0.01983008,0.0050646286,-0.061060216,-0.027643582,0.05023797,0.05007778,-0.07372116,-0.07544251,0.043004572,0.012945217,-0.04282389,-0.00024939663,0.02647377,-0.04079089,0.0032152268,-0.041799206,-0.0113256555,0.068156056,-0.02175315,-0.08811351,-0.026384307,0.007865567,0.06267061,-0.06259708,-0.037538532,-0.01766655,-0.06850651,0.037307847,0.08912585,0.05536676,-0.028959742,-0.025267385,0.051081203,-0.06547755,-0.046738267,-0.055809874,-0.08150694,-0.07269805,-0.001512669,0.06630988,0.07691421,-0.032696728 +3.5.1.56,"An iron protein. Also acts on N-ethylformamide and N-methyl-formamide and, more slowly, on N,N-diethylformamide, N,N-dimethylacetamide and unsubstituted acyl amides.",384,1.0,-0.026091194,-0.08363386,-0.06577586,0.09738299,0.06400457,0.044548783,0.07857854,0.0093330685,0.05394205,-0.07524896,0.024967242,0.02437051,-0.051890682,0.0096853515,0.029672803,0.0011745051,0.026406802,-0.028947612,-0.018755523,-0.00246794,-0.0066569475,0.04404391,-0.0029061208,-0.0665309,-0.05677413,-0.024071978,0.08860265,-0.001436342,0.017555863,-0.04130108,-0.008776226,-0.022173578,0.034449153,-0.01865966,0.039373476,0.042423405,0.040602285,-0.073727675,-0.044155974,0.0141629,0.008217563,-0.027618613,0.013376917,-0.061289854,-0.020585971,-0.036441393,0.029994493,0.013465062,0.033329807,0.08173554,-0.04875193,-0.10336989,-0.006704869,0.04369367,0.01444422,-0.028868798,-0.057879295,-0.08276518,-0.09726903,0.013239877,-0.01710163,-0.03302759,-0.01975911,-0.033839237,0.028771114,0.010779077,0.053147547,-0.066170804,0.014890956,-0.036567062,-0.010334668,-0.020259613,-0.06520653,0.028782388,-0.0059301537,-0.046598956,-0.0077433456,-0.053687595,0.092957355,-0.019559607,-0.06055695,0.07066114,0.046300504,0.059464592,0.07323198,0.054199114,-0.026089985,0.009030417,0.009831662,0.04145275,-0.03650911,-0.016275337,0.05023878,0.0018378521,-0.048934937,-0.017977677,0.014670354,0.034236792,-0.014740027,0.0628175,-0.021701094,0.094137244,-0.08214818,-0.05309909,-0.01822838,0.0029859869,-0.02761161,0.0885149,-0.009943521,0.039641116,0.0019568766,-0.043492917,0.019941416,-0.036934752,-0.0015517876,0.015295029,0.06332692,-0.025428737,-0.05461779,-0.032937452,0.034430344,0.038050152,-0.005505985,0.06698043,-0.010680169,0.05850324,-0.105292596,1.1398571e-33,0.05048274,0.0370724,0.016523195,0.072098866,0.0015961997,0.012180059,-0.08147689,0.0030414253,0.073042,0.005170499,-0.06118072,-0.023967938,0.096087486,0.0036920733,-0.005346276,-0.12684482,0.036313664,0.069310986,0.052744556,-0.028946163,0.026078288,0.15578066,0.10082757,-0.034902852,-0.031743955,0.03286681,-0.053527,0.023563208,-0.018948663,-0.026168397,-0.028184121,-0.07324832,-0.124527015,-0.042330846,0.10499033,0.0014326801,-0.0063278372,-0.01016168,-0.048396595,0.051374827,0.05798682,0.03608974,-0.07950342,-0.056819662,0.0513021,-0.05390856,-0.057021737,0.09739972,-0.048491817,-0.020642925,0.02978824,-0.013386609,0.08652529,0.004405412,-0.10357004,-0.0070350086,-0.048681427,-0.02135032,-0.012374671,0.06771469,0.016616516,-0.06875229,0.021095721,0.026458006,-0.0072698714,-0.022803733,-0.043811545,0.017853916,0.03647518,0.08475003,0.004443769,0.049811482,0.07116652,0.053213645,0.03605962,-0.11349641,-0.13554846,-0.021876594,0.048848566,0.07484205,-0.008894577,-0.0065665296,-0.021694733,-0.032561645,-0.075713016,-0.007208451,0.008464503,-0.042436037,0.056547217,-0.14716235,0.021628035,-0.038520385,-0.015576381,-0.04479526,-0.0054066917,-2.973855e-33,0.023784932,-0.06284074,-0.06058556,0.014192875,-0.028673852,-0.012008724,0.034292463,-0.003542234,-0.060468625,0.010678747,0.1342185,-0.044741306,0.0098012965,-0.09581007,0.048831537,0.079608396,-0.046544265,0.038209457,0.0767983,0.0021907983,-0.10493062,-0.043217152,0.04832522,0.06352916,0.017351864,0.059481885,-0.028976269,0.011942374,0.07564498,0.095907494,-0.02912918,0.013762906,5.489209e-05,-0.16713469,-0.016326884,0.043619182,0.030189719,-0.0063695684,0.012916858,-0.024760932,0.07427016,0.0012674246,0.084904164,0.15247528,0.010896868,0.0028525253,-0.11963467,0.013092378,-0.08351115,-0.018276913,0.037051495,-0.09306112,0.0065864306,0.0057110754,-0.0013061977,0.07509431,-0.0070887716,0.06705515,-0.004674,0.11945637,-0.018062258,-0.0018596813,0.039521094,0.044567443,0.05212383,0.0004496784,-0.07180983,0.017721176,0.02173613,0.010504763,0.045474418,0.030565402,0.048080333,-0.021870703,0.004982926,-0.099348806,0.021998461,-0.010145495,-0.07256412,0.025122914,-0.054012436,-0.09132261,-0.03690723,0.003056344,-0.05563343,-0.011602427,0.044789366,0.008815884,-0.049781047,0.020291,-0.033986084,-0.049084857,0.029445851,0.085114166,-0.026423672,-4.2090182e-08,0.0043897075,-0.07310637,0.007709234,-0.04517216,-0.010721848,0.00983512,-0.036553144,-0.07614797,0.0065423865,-0.008307723,0.031545807,0.11336312,-0.02162699,0.004409427,0.008118932,0.018687634,0.012364055,0.063896865,-0.046976842,-0.0073956694,-0.050758887,0.058491122,-0.005072991,-0.016494438,0.023379024,-0.048242223,-0.0123991575,0.03554213,0.058965065,-0.0068788617,-0.057587545,0.051647745,0.011730318,-0.04688667,-0.061675534,0.021585327,-0.016152777,-0.061509307,-0.030216312,0.037479155,-0.03496148,0.051830802,-0.067604065,-0.011400138,0.037636224,-0.026322672,-0.04910266,0.034252863,-0.056985896,0.028336534,0.018125251,0.012390883,0.04892253,-0.039945323,-0.067750655,0.04970036,-0.01581766,-0.080455795,0.075690135,0.030099463,-0.02997239,-0.04572796,0.08241387,-0.037851755 +3.5.1.57,"Requires Mn2+. Also acts on N-ethylformamide and L-tyrosinamide, and on some tryptophan dipeptides.",384,0.99999994,-0.004393493,-0.06975787,-0.046039995,-0.011607564,0.067697145,-0.0020334905,-0.002707681,0.04382248,-0.013401017,0.02064613,0.082149334,-0.0280568,-0.041360576,0.09785164,-0.007570934,0.062544614,-0.007609575,-0.02275022,0.045792546,0.040555876,0.0608452,0.017554093,-0.003570792,-0.047684297,0.009917157,0.040481314,0.038684912,-0.024033807,0.07153484,-0.037475985,-0.020231018,0.025219249,0.046245325,-0.08325931,0.045890972,0.045869473,-0.029063653,0.0071765594,-0.010607971,-0.0022916629,0.052510966,-0.047247067,0.07494708,-0.025931893,-0.0029632868,-0.028131664,0.07974343,-0.048923824,0.013899008,0.046634115,-0.02694902,-0.039504636,0.017419333,0.06626346,-0.023282092,-0.01727579,-0.12599705,0.011619233,-0.01518892,0.011754244,-0.043632634,0.002775228,0.0040819477,-0.016389322,0.044042382,0.030987374,-0.029348768,-0.09687301,0.015262047,0.016865967,0.023028271,-0.031495694,-0.021702562,0.017645972,-0.03232104,-0.011457122,0.045234352,-0.06424509,0.027987657,-0.022795655,-0.07477869,0.04516694,0.04859347,0.051639717,0.09106357,0.08748018,-0.02622524,0.061432816,0.0034517923,-0.027639277,0.043191236,-0.0019686597,0.007986219,0.028948521,-0.024994873,0.017839456,-0.029321844,-0.019995624,-0.03626281,0.0055177035,0.009019993,0.02807617,-0.14008124,-0.015645131,-0.031274825,-0.023267811,0.06729627,-0.006098478,-0.04965733,0.013710041,0.040572952,0.030022599,0.02796759,0.016595447,-0.027107023,0.009461606,0.04358208,-0.074979246,-0.052514613,-0.07457999,0.033460584,-0.014282535,-0.037618205,0.030428497,-0.045049574,0.0630727,-0.006842348,3.1459395e-33,0.12074693,0.055038676,0.0029502162,0.060707066,-0.00566692,0.049762208,-0.033407502,-0.07871552,0.05974464,-0.059748683,-0.09178222,-0.14649087,0.031298537,0.052446183,-0.02323419,-0.04955038,-0.02116259,-0.011416126,0.10594113,0.003257665,0.0065995273,0.023949426,-0.03174862,0.001676286,-0.03334153,0.08104911,0.11123377,-0.012673052,0.088937394,-0.029574879,0.015687786,-0.04711579,-0.09419876,0.030283855,0.05854266,0.072941385,-0.09436518,-0.00076092285,0.002696841,0.03643398,0.003350755,0.12611242,-0.06358589,0.018012082,0.12276616,-0.063829176,-0.024129398,0.08087566,0.01097091,0.035843164,0.016934086,-0.011955861,0.014673651,-0.0020898567,-0.028289327,-0.013606262,-0.006913584,0.00040224107,0.022867523,0.062165562,-0.1097673,-0.041464686,0.0038236617,0.024633845,0.006023056,0.06654434,-0.0631421,-0.09206232,-0.049157992,-0.04411764,-0.005708339,-0.10805979,0.06393661,0.05132771,-0.008844295,-0.055520497,-0.056888632,-0.02498371,0.04508994,0.017510941,0.0116115725,-0.07772324,-0.0010444113,0.00048706104,-0.06841593,-0.05037361,-0.01713432,-0.08530556,0.020534974,-0.012334138,0.066449866,-0.03814104,-0.018511867,0.008269529,0.0048245233,-3.876401e-33,-0.017360263,-0.07244576,0.029143551,-0.035805367,-0.063056596,0.015290847,-0.022748925,-0.15985982,0.04280457,-0.015604719,0.07951789,-0.011186847,-0.021127952,-0.033954013,-0.0637337,-0.03439754,-0.03736904,0.10750939,0.06565719,-0.04110137,-0.004730925,0.08735855,0.049116705,0.047334727,0.098306045,0.09353837,-0.012525067,0.05297687,0.01922378,-0.0043700286,-0.051674306,-0.0121548725,-0.10672046,-0.098773405,0.027331706,0.04955655,-0.02728048,-0.013065636,-0.032641288,-0.017649487,0.04210264,0.013514219,0.078510046,0.10013547,-0.05159353,-0.017121272,-0.07876533,-0.010676129,-0.00505004,-0.018639127,-0.054575384,-0.06660015,-0.035807487,-0.046288196,0.049871966,0.020843498,0.026902096,0.0381845,0.03667229,-0.038969185,0.0053035007,-0.012806673,0.0033579236,-0.039313275,0.0028001931,0.0046451064,0.010870737,0.07318804,0.07674948,0.020064346,0.015764799,0.047172032,0.14405718,-0.0036284016,-0.041312125,-0.08088686,-0.044412818,-0.060457718,0.08623552,-0.07749916,6.5517124e-05,-0.033351656,-0.016559187,-0.008111355,0.039330285,-0.08000798,0.06159059,0.009559952,-0.051521245,0.041854165,0.012732845,-0.035549603,0.017162781,0.0900532,0.02656617,-3.1361413e-08,0.02867051,-0.06673664,-0.00917075,-0.10421124,-0.06146006,0.009276573,-0.005974453,-0.028381456,0.04996792,-0.0333427,0.075604305,0.09046008,0.035756692,0.005604683,0.07751603,-0.039627437,0.013790776,0.04061105,-0.092740856,-0.057302777,-0.074001245,-0.033753917,-0.07378359,0.0028702524,0.015396199,0.0069423323,0.08733159,0.08210527,0.06215648,-0.0060650054,-0.015626485,0.0010407341,0.030084219,-0.054645557,-0.01852469,0.122728065,-0.021032415,0.0019819348,0.009327424,-0.044906236,-0.09329291,0.043229327,-0.030762533,0.031824276,-0.016681876,-0.04702939,-0.06924708,0.05751218,-0.059728913,0.02171648,0.0075853043,-0.07382742,0.033857975,-0.07582043,-0.119706176,0.054849077,-0.030864729,0.0145213,0.037664212,-0.061583478,0.017154511,0.0029541834,0.08038512,-0.019161435 +3.5.1.58,"Also acts, more slowly, on N-benzyloxycarbonylalanine, but not on the corresponding derivatives of other amino acids or on N-benzyloxycarbonylpeptides. Requires Co2+ or Zn2+. cf. EC 3.5.1.64, Nalpha-benzyloxycarbonylleucine hydrolase.",384,1.0,-0.024438357,-0.06588116,-0.048910964,-0.012228844,0.04279959,0.017586393,-0.05775405,-0.01778853,0.035082377,-0.07049518,0.038738266,-0.053629667,-0.06561951,0.10994446,-0.0061309533,-0.0022382631,-0.036529962,-0.040780935,-0.010626368,-0.063606724,-0.03823828,0.07103761,0.0015890534,0.01560471,0.024587508,-0.10050426,0.033514585,-0.05899638,0.03155471,-0.010068443,0.019649982,-0.049510166,-0.07589169,-0.013672693,0.109530464,0.0067714867,-0.057501905,-0.024637865,0.059000507,0.080536,0.034534067,-0.0041308636,0.026905548,-0.037973,-0.017548824,-0.011693597,0.025963854,-0.033591967,-0.019409068,-0.018851297,-0.10260321,-0.06620667,-0.061878726,-0.024781324,-0.0079395315,0.033246975,-0.121000454,-0.017055832,0.013415713,0.012403171,0.011536123,-0.062423542,0.030780105,0.0055335434,0.073226936,0.006082745,0.080268316,-0.15735462,0.025543012,-0.0331282,-0.04339472,-0.047200672,0.0019727442,-0.033168726,-0.048444755,-0.083774135,-0.020278338,-0.006944266,0.051553726,-0.06752069,-0.028260756,-0.015023931,0.028946571,0.03474184,0.030948382,-0.019349644,-0.043721948,0.011011017,-0.0021672687,0.026548011,0.03830947,-0.031122748,0.010190852,0.037390746,-0.04293872,-0.002289561,0.09465328,0.01951606,-0.048480548,0.05183707,-0.003303659,0.0702345,-0.039511006,-0.075718105,-0.10783596,0.08957345,0.08828339,0.07635166,-0.038481403,0.05046262,-0.027555259,-0.009896151,0.08049107,-0.038023204,-0.0061708214,0.029879676,0.019144718,-0.08136575,0.026464187,-0.003563293,0.027809465,-0.07086017,0.071831346,0.03883108,-0.06432676,0.1442957,-0.05853264,5.282176e-33,0.059857886,-0.0062622074,-0.009067082,-0.0007008243,-0.010216258,0.020963375,-0.08156288,0.021419613,0.007334877,-0.12473235,-0.0034990106,-0.05105063,0.012052467,-0.010000107,-0.01781136,0.011254669,-0.0219157,0.0021819144,-0.011690241,-0.0024589237,0.04354579,-0.008135692,-0.0088983895,0.034477312,-0.0029891448,0.012566038,-0.01601523,0.01677955,-0.04761182,-0.00087878836,-0.008278535,-0.03588486,-0.10390536,0.027302502,0.06543847,0.027285302,-0.02256097,-0.030615106,0.03972878,0.011109601,-0.044070184,0.048734426,-0.00054928433,-0.086426735,0.031593375,-0.019323418,-0.06566157,0.1547048,-0.08290929,0.03461917,0.066602975,0.028525783,-0.038717985,0.018393757,0.012756581,0.0061305366,0.012663192,0.030721707,0.06524067,0.04870897,-0.018194852,-0.001134641,-0.016886503,-0.0036809305,-0.00348771,0.034657557,-0.08750107,0.025696509,0.005857444,0.050882924,0.00089528126,0.012725582,0.08824422,0.04011039,0.082726695,-0.18125476,-0.038481608,0.0050700097,0.06788134,0.05175235,0.030673876,-0.013465245,0.066909455,-0.0753488,-0.00627323,-0.024088217,0.034923416,-0.073637284,-0.007830683,0.048268814,-0.060748927,-0.047728203,0.014872137,0.009211331,0.040438082,-5.6251625e-33,0.06203345,-0.075591445,-0.027862595,-0.042527463,-0.008829698,0.011962806,0.051312473,-0.077505834,0.033915807,-0.06408057,0.09043032,0.010756032,0.0063249758,-0.023625366,0.07356578,-0.022285305,0.014799847,0.06861717,0.08998827,-0.027702292,0.015156646,0.019494241,-0.10836413,0.04642398,0.08921276,0.046479452,-0.10672876,0.08291897,0.06303201,0.04982815,-0.0954792,0.06572379,-0.07816017,-0.0688141,-0.007152012,0.121668205,-0.05349157,0.011446637,-0.059204936,0.032531776,0.016242633,-0.030195702,-0.027664514,0.05697246,0.02526129,0.040678035,-0.04528558,-0.039505295,-0.049673457,0.014813242,0.03959748,-0.0061967433,-0.06462958,0.013084453,0.011725497,0.13837112,0.044633616,-0.021604585,0.020018674,-0.028505202,-0.028546415,-0.006360649,-0.013460147,-0.039033055,-0.0074891816,-0.006404222,-0.07305827,0.0719095,0.12523226,0.039699994,-0.010681397,0.015745442,0.08079223,0.03289673,-0.11849081,-0.037190154,-0.011824062,0.0026934973,-0.013655276,-0.071850106,0.014295454,0.02079683,0.058456548,-0.024163032,0.0042831157,-0.026914725,0.022950472,0.0047317976,-0.023432186,0.025030054,-8.135183e-05,-0.04160473,0.015331349,0.040898487,0.02339039,-4.2142457e-08,0.023682062,-0.024245083,0.028467469,-0.013500162,0.02571718,0.018563524,0.021679979,-0.010924286,-0.017029947,-0.10943947,0.025236232,0.07921251,0.0671285,0.10066434,-0.0075209406,0.00065377343,-0.064441994,-0.0028407376,-0.040492382,0.020887285,-0.086741745,0.035490397,-0.053578183,0.040405903,-0.07892133,-0.04458987,0.03261932,0.091833524,-0.012015767,-0.06198967,-0.02317739,0.008274802,0.06863105,-0.02748143,0.008781284,0.01891535,0.04287347,-0.034749918,-0.050521124,-0.008860592,-0.040642314,-0.022572175,-0.024298174,0.007226801,0.070705675,-0.077434495,-0.043603003,-0.045202643,-0.009984451,0.048465036,0.050573714,-0.0046887114,-0.027336758,-0.026880046,0.04067732,-0.0037852773,0.0071116243,-0.05291217,-0.012081415,-0.027154319,0.047858614,0.05714571,0.19343232,-0.04049572 +3.5.1.60,"This lysosomal enzyme acts best on palmitoyl ethanolamide, with lower activity on other N-(long-chain-acyl)ethanolamines. It is only active at acidic pH. Unlike EC 3.5.1.99, fatty acid amide hydrolase, it does not act on primary amides such as oleamide, and has only a marginal activity with anandamide. The enzyme is translated as an inactive proenzyme, followed by autocatalytic cleavage into two subunits that reassociate to form an active heterodimeric complex.",384,0.99999994,0.0007199838,-0.11463247,-0.09473345,-0.021510513,0.09863531,-0.020232832,-0.086004525,-0.023109054,0.0074839853,-0.024806693,0.03854763,-0.0014397869,-0.113869585,0.06513012,0.031112347,0.05659315,-0.028453331,-0.07468838,-0.023824438,-0.016810209,0.09257052,0.02193538,0.054367788,-0.020693451,0.011058263,-0.008474367,0.093590595,0.015417926,0.012029995,-0.106457196,0.046158794,0.016053215,0.056627132,-0.05250193,0.04204673,0.006752351,-0.068357885,-0.027330998,0.06681329,-0.037981216,0.08487954,-0.079061836,0.024054399,-0.049839977,-0.053660985,-0.044246517,-0.048668418,0.04895605,0.03996845,-0.036081515,-0.036804486,-0.12267694,-0.00025653615,0.024809957,-0.03364116,-0.0072551523,-0.061166488,0.033584792,-0.0074416837,0.059082966,0.041233737,0.083963044,-0.011909478,-0.014706775,0.027841887,-0.06607102,0.04493679,-0.102403626,0.020009603,0.0039437483,-0.04541584,-0.1408019,0.023629269,0.05604483,0.027584031,-0.06551512,0.00030494027,-0.02254927,0.0034257954,-0.049202085,0.01317893,-0.04340798,0.042035498,0.10470731,0.044764504,-0.032307845,-0.036010075,0.055259123,0.09612615,-0.026767714,0.02576431,-0.04016993,-0.04979198,-0.023664704,-0.03628128,0.0025924651,0.028394492,-0.003260245,-0.099883415,0.008757977,0.022038048,0.09093045,-0.033189375,-0.12872127,-0.05770178,0.06901551,0.017245037,0.06532005,-0.034521207,-0.020226981,0.028498283,-0.0046892585,0.034707885,-0.015167527,-0.08495863,0.027069375,0.024680095,-0.056470472,-0.035423256,-0.045565214,-0.007146861,-0.0005620584,0.14035012,0.06620192,-0.011663463,0.039046925,-0.07961885,3.9192374e-33,-0.008624335,-0.030255217,-0.061371773,-0.07611069,-0.006642977,-0.06379934,-0.037847154,-0.013785115,-0.04085878,-0.060531136,-0.024830865,-0.0046412116,0.05109496,0.06367561,0.025435146,-0.0128460815,-0.0026586875,0.03152598,0.022570185,0.011522959,0.015894847,0.0443861,-0.032082595,0.039721504,0.023704732,0.08712925,0.049998052,0.023929808,0.059729952,0.016576242,-0.03806427,-0.039573677,-0.07691707,0.040513225,0.027013127,0.13150087,-0.04883995,-0.01920264,-0.005660757,0.009894325,-0.005228363,0.037358355,0.035517003,-0.041912608,-0.021110732,0.011767094,-0.013347701,0.10689566,0.002031987,0.04650994,0.056226112,-0.089162424,0.08191456,0.051016185,-0.10637088,0.05605511,-0.033262122,0.010440309,0.019788686,-0.030256772,0.004652448,-0.058361776,-0.07538749,0.044626497,-0.058375787,0.024409475,-0.08068562,-0.075621076,0.0035199213,0.046397917,-0.018156614,0.00810401,0.13710023,0.017657159,0.061298475,-0.030646559,-0.012460593,0.04059755,0.00072479417,0.08443076,0.023893327,-0.065182574,0.012169062,-0.040385984,-0.035557892,0.0073296353,-0.018916136,-0.02664026,-0.04055414,0.0054807174,0.0024729192,-0.084345095,0.026662763,0.08969364,0.009006748,-5.1691126e-33,0.09095183,-0.096875794,0.056532923,-0.031072717,-0.030863011,0.028669892,0.023579426,-0.008742458,-0.031046074,-0.06648451,0.026901675,-0.025035769,-0.014125757,-0.049512446,0.05943065,0.04175962,-0.03430466,0.030953573,-0.003727391,-0.014034485,-0.025507059,0.095542185,0.02217236,0.080169834,0.0485887,-0.017202033,-0.0040691337,0.088092186,-0.010582619,0.03165237,-0.022993762,-0.009885723,-0.04303619,-0.06645268,-0.018583901,0.121326394,-0.024202725,-0.027969431,-0.018841345,0.04602633,0.007036171,0.0132534765,-0.012837118,0.020239096,0.067434736,0.06790792,-0.07250526,0.016067268,-0.06358991,-0.0783928,0.04259043,0.012104634,0.034869224,0.019407628,0.045311753,0.07938317,0.027767895,0.009561803,-0.08322365,-0.044200145,-0.040581286,-0.008056511,-0.01079961,0.04860324,0.02754879,-0.008513575,-0.050788622,0.08616075,0.020456614,0.035349026,0.02851688,-0.05608762,0.029073259,0.121504486,-0.015598541,-0.02722193,-0.04517769,-0.07154595,0.009337139,-0.06968663,0.014572666,-0.060508523,-0.0063251886,-0.05542788,-0.008557314,-0.024551049,0.034421433,0.07011072,-0.0036067776,0.04324915,0.021704445,0.001525519,-0.047262605,0.051187858,0.08485464,-4.739879e-08,0.0701767,-0.077917226,0.00039317357,-0.030777305,-0.0136023285,0.014793133,-0.0040454464,0.009037247,0.033971738,-0.020355936,-0.045288946,0.03520816,-0.028541807,0.041232586,-0.0038412586,0.013056147,0.008444052,0.06503561,-0.069510244,-0.061591458,-0.07141044,-0.0016799743,-0.06121367,-0.0036830113,-0.03288746,-0.0002552406,-0.0051233945,0.0401522,-0.06791377,-0.012741559,-0.031999666,0.0961703,-0.021888323,0.005420666,-0.03780259,0.06108449,0.03725465,-0.07105849,-0.0210302,0.097184435,0.045263313,-0.034908578,-0.09596736,-0.031193005,0.014803663,0.0050605144,0.002878867,-0.04673711,0.02635122,-0.0065809954,0.067920975,0.0029728706,-0.007188496,-0.04713479,-0.058962665,-0.02011548,-0.094112284,-0.015387082,0.055960674,-0.07631897,0.09052976,0.046190888,0.1781164,-0.019860929 +3.5.1.61,"An enzyme from Leucaena leucocephala leaf, which also contains the toxic amino acid, mimosine.",384,0.9999999,-0.055215344,-0.042451333,-0.048767198,-0.02612491,0.111649424,0.034327436,-0.03246402,0.13265406,0.02145316,0.039457615,0.06555317,-0.022190759,-0.03285672,0.046773694,-0.09968611,0.06684252,-0.009224802,0.046862774,-0.069938086,-0.047113463,0.082737796,0.080217324,-0.012301541,0.025433,0.0057230834,0.058260903,-0.0041588633,0.022172559,0.016876865,-0.013491317,0.004057344,-0.045867488,0.07194219,-0.054865487,-0.0026315122,0.014766984,-0.010289594,-0.12296136,0.055310197,-0.005951933,-0.039774273,0.039843816,-0.022428554,-0.038273722,-0.016164757,-0.06580807,-0.00026783562,-0.03240131,0.00021780442,0.027974294,-0.030804409,-0.07538576,-0.088552564,0.03854539,-0.02902657,-0.07559418,-0.03819005,-0.022611571,-0.008940993,0.09059213,-0.0022252293,0.041769825,-0.022837007,0.0057922974,0.0184883,0.0025600921,-0.03654728,-0.015199309,0.015440603,-0.041284353,0.010656134,-0.14414766,0.029151851,0.002650101,0.0100104315,0.033970956,0.0148655055,-0.00040833326,0.039615452,-0.04024452,-0.003390151,0.024059119,0.015195104,0.052943848,0.011065646,0.054844856,-0.02095375,0.0672755,0.0478835,-0.010180833,0.06610805,0.028068388,-0.062195208,0.006060037,-0.0071426765,0.11088065,-0.019711234,-0.0025970726,-0.049064707,0.0022245564,-0.014446725,0.013998892,-0.024750456,-0.087747715,-0.09343018,0.0008229809,0.036230292,-0.009017955,0.0063857534,-0.07003428,-0.06315223,0.0011661601,-0.089723095,0.06922554,-0.069387175,-0.023039218,0.089641765,0.017315174,-0.055856604,0.026760586,0.03872159,-0.07164862,0.015316018,0.05497194,-0.035989873,0.00806688,-0.08221235,-3.031534e-34,0.07557629,-0.012007444,0.027154302,-0.02974274,-0.003379581,0.00854886,0.016748697,0.07093747,-0.041042674,-0.050636593,-0.10857186,-0.06474573,-0.05309078,0.008445785,0.024704212,0.049153898,-0.021408359,-0.082110666,0.10407196,-0.012755117,0.06109249,-0.023777688,-0.02337724,-0.06135963,0.033836372,0.051228136,-0.0020024572,0.002826073,0.022838686,0.025273835,-0.008996782,-0.10140002,-0.044352263,-0.00081969454,0.0074338475,0.0007081798,-0.06794897,-0.07014327,-0.049299654,0.04588289,-0.045284614,0.01717051,0.023280742,0.05155128,0.099864505,0.009670884,-0.05649922,0.040253013,0.015971866,0.019680537,0.013863344,-0.06378029,0.090289816,-0.004801154,-0.04476772,0.06803112,-0.034779713,0.0648151,0.03795499,0.092649475,-0.005869464,0.059126597,-0.026850685,0.07273094,0.052688204,-0.023846708,-0.14921676,-0.047547802,0.008868255,0.009079004,-0.037210666,-0.052074477,-0.017931318,0.05172549,-0.034044128,-0.09038612,-0.020547278,0.029733494,-0.006704001,-0.021532139,0.08000447,-0.0449157,0.041810438,0.013269492,-0.04727569,0.040142205,-0.030011185,-0.036093898,-0.03573568,0.04765716,0.098848246,-0.0512424,-0.045964878,0.010669031,0.011114252,-5.507796e-34,0.08895968,-0.11208061,0.042317126,0.001643806,-0.049182173,0.052977704,-0.003599091,-0.0089214435,0.04320585,0.027441278,0.010053243,-0.029425003,0.04435564,-0.0878241,-0.008901322,0.04182693,0.0735358,0.05599165,0.048302405,-0.022839155,-0.043595597,0.08625858,0.05422139,-0.064146034,-0.013036981,-0.031967722,0.05297987,0.08548259,-0.008425977,0.02967129,0.03323791,0.01361917,0.007900148,-0.06813835,-0.0072354707,-0.02897798,0.026194427,-0.10323515,0.029120471,0.007319288,0.018993597,0.022001926,0.03778659,0.04806366,0.024430102,0.045675036,-0.073315844,0.035172977,-0.004846621,-0.04049062,0.05655953,-0.048422042,-0.036793817,0.034845732,0.10839039,-0.028261315,0.028884431,-0.01668068,0.018453969,0.00034985028,0.025752036,-0.045663197,-0.07701593,0.025638381,0.09716286,0.10484338,0.021861328,0.0038793895,0.010655476,0.032192025,0.10284544,-0.049141407,-0.048168108,-0.017719679,-0.09213488,0.019462403,-0.05867426,-0.044040143,0.0021943285,-0.04111892,0.029628355,-0.019787196,-0.008766078,-0.036246844,0.009382762,-0.10195847,0.0037093705,0.18754697,0.025894377,-0.0059174052,0.0134097235,0.013719469,-0.049160805,0.06062458,0.1154056,-2.4038869e-08,-0.013842706,-0.088874795,-0.0014374026,-0.03498351,-0.023268428,-0.023305101,0.10795375,0.00089789997,0.03647702,0.016019983,-0.04893255,0.023409272,-0.019541962,0.023243649,-0.018137565,0.024489222,0.051235233,0.07944851,0.01351899,0.08064012,-0.043229897,0.008899754,-0.0193808,-0.025476644,-0.013217245,-0.09158816,0.059300397,0.052068252,0.05201583,-0.033326454,-0.035166997,-0.009856939,0.035901815,-0.069690675,-0.13799527,0.0413902,-0.014012997,-0.06578387,-0.041721232,-0.030360382,0.03904774,-0.019785486,0.039578166,-0.047436863,0.032169025,-0.0031519455,0.041730117,0.039345384,-0.004891175,-0.01707054,0.05331959,-0.049701374,0.013809592,-0.03532871,-0.08347568,-0.052672584,0.051765837,-0.059314396,0.0487508,-0.09818461,0.00022059696,0.009130428,0.15063733,0.060533877 +3.5.1.62,"The enzyme from Micrococcus luteus also acts on N8-acetylspermidine and acetylcadaverine, but more slowly.",384,0.99999994,-0.062445052,-0.12101279,-0.10043811,0.009580702,0.0914048,0.036879905,-0.086171776,0.06089414,0.032408174,0.019008102,0.04965322,-0.0070906603,-0.08601426,0.10728279,-0.09577471,0.03789172,-0.018179616,-0.023723764,0.015290242,-0.04438209,0.094768435,-0.01917609,-0.047197416,-0.09734677,8.143925e-05,4.5226843e-05,0.02945311,-0.001465737,-0.06909069,-0.06230131,0.009506207,-0.04701777,0.11456337,-0.034780577,0.106432594,0.018024508,-0.020079108,0.011214186,0.12841651,0.07660223,-0.004022032,0.021519164,-0.026589278,-0.013551015,0.007930162,-0.02857263,0.016074061,0.015630785,0.018947693,0.0286868,-0.022137418,-0.008107758,-0.0859318,-0.009101156,0.01521556,0.022446804,-0.11334266,-0.06525524,0.04086308,0.02557542,0.013108,-0.001013753,0.052582566,0.012041107,0.0074995197,-0.053435747,0.09388303,-0.0894512,0.016287586,-0.02532511,-0.0070217005,-0.04962944,-0.060380753,0.0708818,0.05897544,-0.023090819,-0.015286669,-0.03474678,0.01815129,-0.005847638,-0.041536007,-0.054751545,-0.029755741,0.021764219,0.06198536,-0.016215,0.04437097,-0.020022273,0.07235673,0.013736951,-0.0056561814,-0.044382036,-0.014987351,-0.08586356,0.0075216806,-0.034841046,-0.022841206,0.03637801,-0.061603222,-0.031739015,-0.033339355,-0.017646832,-0.026384493,-0.024623735,-0.035764605,-0.005462101,0.075882,0.056707554,0.013343007,0.03598191,0.020247886,0.01697387,0.017998898,-0.011087362,-0.033459947,0.05676772,0.029235046,-0.071685426,-0.072745,0.057562783,-0.0011248152,-0.040554184,0.042077843,0.041656554,-0.019043092,0.1500783,-0.03939905,2.507661e-33,0.019393861,-0.040828813,0.019935468,-0.04085638,0.0644309,-0.043250896,-0.0044841818,0.040827356,0.024555065,-0.09689545,-0.03626349,-0.0439995,0.08481281,0.027197415,-0.068618774,0.030558586,0.047543634,-0.07273141,0.012100019,0.0023810968,0.02245561,0.0398832,0.03923108,-0.011746793,0.023009004,-0.036521126,-0.050541468,0.03564755,0.114723176,-0.028515486,-0.034479093,-0.10658253,-0.03572754,0.0136432,0.06614297,0.07610193,0.016991716,-0.08455296,0.058715507,-0.0005913796,0.015174045,0.090061784,-0.011611854,0.021059819,-0.024082579,0.012178462,-0.12094539,0.03709136,0.01009046,0.033590905,0.08332255,-0.079839155,0.06431806,-0.0055681397,0.00821329,0.07792431,-0.09274241,-0.015145275,0.032057624,0.043736532,0.03367302,0.021117937,0.028899366,-0.014820029,0.025677059,0.04594438,-0.057887703,-0.016217183,0.014476514,0.026488723,-0.0504037,-0.025353085,0.067283556,0.081062384,0.039068762,-0.017879961,-0.05381964,0.040022142,0.027889939,-0.06728474,0.06634722,0.0039739762,0.03846191,0.026758369,-0.08072626,-0.011001226,0.00096846034,-0.05122817,0.015234407,-0.012589481,0.07320559,-0.07553502,-0.035292547,0.030655622,-0.010106888,-3.6767494e-33,0.09677087,-0.14959614,0.05812159,0.0065785307,-0.0535357,0.12681046,0.011504743,-0.02952925,-0.052627202,-0.010552767,0.06083745,-0.030255249,0.0109989755,-0.058605917,-0.011504689,-0.012081268,0.040871248,0.06376299,0.05253747,0.0032479595,-0.038903784,0.041705225,0.08752245,0.004624663,0.02455166,-0.020578334,-0.02414038,0.06185593,-0.03606215,-0.011349872,-0.06822242,0.02227095,-0.025418574,-0.08519608,-0.057194073,0.10134784,0.01195688,0.0017737673,-0.06767576,-0.03811847,0.04297036,-0.034386538,-0.02419932,0.08329227,-0.027439715,0.060445447,-0.01673208,0.0010606197,-0.1064456,-0.022262562,0.03507658,-0.042660628,-0.041548517,0.022727206,0.023732329,0.103453115,0.03285756,0.01867897,-0.02140325,0.017045476,-0.038096454,-0.052443426,-0.03201656,-0.019251723,0.10205448,0.095959395,-0.051814053,0.07201607,0.022565514,-0.07107124,0.053925015,0.005241726,0.04072172,0.049877346,-0.039247602,-0.056646775,-0.049907513,-0.07603759,0.008108306,-0.03756871,-0.012871243,-0.03856633,-0.019601217,0.0060984786,-0.09292589,-0.025365004,0.08891787,0.037618432,-0.0152511755,0.04559532,-0.02136546,-0.049868584,-0.010218079,-0.012042175,0.029287336,-2.8633409e-08,0.062008377,-0.006650013,0.08860291,-0.062604755,-0.021106083,-0.01012613,0.024369251,0.023398431,0.049001735,-0.053315274,0.013528521,0.08128416,0.042846467,0.01810898,0.05086255,0.049744178,-0.033805475,-0.00447014,0.0015212501,0.025248423,-0.10946829,0.062751494,-0.08049545,0.01534322,0.019198772,-0.07725116,0.037961528,0.106108956,-0.024121195,-0.053868115,-0.017645855,0.0006057657,-0.023274513,-0.0715106,-0.06174207,-0.029429266,-0.034575958,-0.051510893,0.022143211,0.021434288,0.0047774026,0.053219486,-0.09935028,0.0041158237,-0.005145486,-0.005806324,0.01339757,-0.002601229,-0.007466352,-0.0025272267,0.041170288,-0.011696076,-0.010480542,-0.04970869,-0.0808155,-0.08271669,-0.024480954,-0.08774849,0.021167487,-0.010644476,-0.017906392,-0.013427563,0.16259138,0.052949335 +3.5.1.63,Also acts on N-acetyl-beta-alanine and 5-acetamidopentanoate.,384,1.0,0.008327892,-0.11905517,-0.048297536,0.030267138,0.045676846,0.06664947,0.019616485,-0.004001251,0.048088435,0.009634326,0.022084901,0.034776013,-0.066756815,0.046716776,-0.0382574,0.038599867,-0.016885674,-0.017276313,-0.013166227,-0.05400411,0.010900594,0.031022608,-0.01679219,-0.04057218,-0.017038582,0.08536882,0.016606366,0.024461446,0.012712656,-0.10850259,0.0004692212,0.00093315507,0.014411848,-0.023948599,-0.0139541635,0.0084904805,-0.09409043,0.012693483,0.08592449,0.046210382,0.062467318,-0.028770013,-0.02240699,-0.022191152,0.020727301,-0.054408282,-0.057864126,0.022337211,0.07612881,0.07581449,-0.023247667,-0.0962158,0.0042136693,0.043577626,0.01209895,0.01127131,-0.16205056,-0.068160735,0.021624623,0.06251711,-0.007759813,0.011998281,-0.015291405,-0.025306405,-0.009440496,0.056622557,0.01844164,-0.08357221,0.023592474,-0.01988349,-0.0073425425,-0.068570144,-0.0062421574,-0.0036131977,-0.027382815,-0.026262026,-0.048635304,-0.029842153,0.006027274,-0.009205441,-0.022066979,0.013297924,-0.0015643092,0.049009647,0.06710044,0.012563743,-0.020669304,-0.031019853,-0.0052436367,0.04563566,0.0133755375,-0.037390888,0.048888486,-0.02570454,-0.0426139,-0.058325153,-0.013243186,0.018554365,-0.08041092,0.013712529,-0.021748312,0.037008625,-0.057536576,-0.04971985,-0.04590339,0.03216117,0.036071904,-0.04074654,-0.027918477,-0.010262328,-0.039761174,-0.022387719,0.009183285,0.012368098,-0.048112035,0.058949865,-0.013146064,-0.00072495826,-0.012030783,-0.011753253,0.040448677,-0.024736652,0.03789325,0.034442086,-0.02112755,0.1254797,-0.011562658,6.7798175e-34,0.0367724,0.0025522287,0.02537035,0.03727651,0.08882938,-0.014881745,-0.076264255,0.020735031,0.103494674,-0.051488407,-0.033396356,-0.015357925,0.04426523,0.018054757,0.017164739,0.045496084,-0.017887171,0.023024753,0.066409685,-0.014331599,-0.022055537,0.077456154,-0.058429774,0.021813357,-0.07950258,0.0054447064,0.0032861817,0.0519912,0.08177145,-0.00033757187,-0.016434217,-0.01904956,-0.019147385,0.0070951437,-0.0066425526,0.08680477,-0.0076115327,-0.005292498,-0.012302899,0.04628934,0.038918808,0.03858657,-0.08768707,0.026770318,-0.00077184103,-0.0718657,-0.090793744,0.052214105,0.012780643,0.028462227,0.04433404,-0.06099655,0.098656304,0.01840135,-0.031023199,0.05702548,-0.081506975,0.00088469224,0.0016025953,0.05848178,0.023790577,-0.023666838,0.028740987,-0.049526315,-0.015494634,0.079622395,-0.03663591,-0.09841272,-0.006502803,-0.006429253,-0.012394518,0.023616267,0.14150515,0.09538355,0.032505848,-0.019555891,-0.03305801,0.037786633,0.03950945,0.008354432,-0.020559138,-0.05955892,0.071735464,0.010545543,-0.03954989,-0.031621832,0.02644938,-0.11074765,-0.006022002,-0.030662639,0.054715887,-0.0328982,-0.059965096,0.022019446,0.002614698,-1.7007098e-33,0.011712649,-0.12343774,0.022618113,0.0097875735,-0.082916535,0.08197555,-0.0056784973,-0.042223535,0.0057226713,0.012225353,0.0702889,-0.007827249,-0.028973497,-0.051285177,0.015562388,-0.03689499,0.013753629,0.09476828,-0.0054627247,-0.013302241,-0.0078809485,0.038773056,0.044169128,0.099797405,0.07031072,0.040896684,0.031966683,-0.05199964,0.039765216,0.057626616,0.019612333,0.005106636,-0.04192717,-0.10387864,-0.07150169,0.08540663,0.012287242,0.023571942,-0.11682995,-0.008179739,-0.028951045,-0.015318831,0.024343902,0.09657393,0.013233404,0.05258026,-0.0078392215,-0.0055998745,-0.09189617,-0.022334324,0.041290984,-0.04762787,-0.047070287,0.03314629,0.035539974,0.0979948,0.0009109415,-0.009139076,0.0124729,-0.008868045,-0.0076073,0.017016375,-0.04443526,-0.054581583,0.109408006,-0.009588566,-0.03058193,0.04686275,0.041484673,-0.014378948,0.0060674297,-0.025800843,0.069751725,0.0788413,-0.017979965,-0.055590123,0.00017319206,-0.1637424,-0.02527433,-0.09130478,-0.08894736,-0.025736675,-0.051527258,-0.029621871,-0.111603215,-0.013508925,0.051418018,0.09574972,-0.012400019,0.11462716,-0.008360451,0.005993583,-0.14481527,0.041786,0.02966429,-2.5332726e-08,0.14197236,-0.048291717,0.05182576,-0.03940954,-0.045763437,0.010130557,0.04908144,0.058682587,0.04475604,-0.061205205,-0.021645037,0.11487182,0.03222316,0.06821274,-0.010904385,-0.000280984,0.028981818,0.06387974,-0.047787625,0.0028004132,-0.117073104,0.021427495,0.05380341,-0.05699019,-0.002692069,-0.118925154,0.060056772,0.10939586,-0.0062067895,-0.022760287,0.025034303,0.0019414084,0.028940964,-0.12482192,-0.029309066,0.06533247,0.0611447,-0.032093894,0.008340719,0.036222342,-0.07699066,-0.062742725,-0.09842007,0.039477415,0.0165098,-0.051759474,0.0011714522,0.028584614,0.0039091376,-0.029351624,-0.0013293455,0.0065165497,0.009293937,-0.071138985,-0.0902719,0.002744649,-0.037433974,-0.050196126,0.10275777,-0.033032503,0.00074137026,-0.025085364,0.08966933,0.03830153 +3.5.1.64,"Also acts on Nalpha-t-butoxycarbonyl-L-leucine, and, more slowly, on the corresponding derivatives of L-aspartate, L-methionine, L-glutamate and L-alanine. cf. EC 3.5.1.58 N-benzyloxycarbonylglycine hydrolase.",384,0.99999994,-0.03477144,-0.087120265,-0.016871788,-0.018832548,0.05596793,0.09002519,-0.0696633,-0.010091286,0.04697675,-0.0022556286,0.014186649,-0.009449453,-0.018393505,0.06808644,-0.022750355,0.021754734,-0.06387476,-0.05018296,-0.048097696,-0.07585801,0.0351215,0.07400444,-0.032963973,-0.015540454,0.118735164,-0.047538586,0.06946435,-0.031140279,0.0039202035,-0.0482642,0.03083416,-0.059087787,-0.017132994,-0.040704664,0.06251186,0.0012424506,-0.13092107,0.010989651,0.089395955,0.045199055,0.05239487,-0.051179215,0.017594576,-0.068242244,-0.044643026,-0.06284246,-0.04175622,-0.03490863,-0.016013974,-0.0020969762,-0.02176032,-0.027633237,-0.081384055,0.022171738,-0.012384443,-7.949516e-05,-0.13209406,-0.02197593,0.0021149875,0.043443616,-0.0072649787,0.0058349855,-0.0041946955,0.0041160933,0.058123484,-0.026916234,0.03495565,-0.10399771,0.06285081,-0.0686059,-0.04696164,-0.07800419,0.048058916,-0.0437745,0.011635013,-0.119164586,-0.01796557,0.05711138,0.012868592,-0.07680131,0.03596841,-0.013066399,0.015714848,0.032914415,-0.04170877,-0.02126997,-0.057288036,0.0406016,0.09132705,-0.015879171,0.017722456,-0.08655283,-0.07561345,-0.011071932,-0.017496878,-0.0015147352,0.0309448,0.00046985687,-0.0319766,0.015359865,-0.0037324412,0.069062255,-0.07082627,-0.059040006,-0.10038011,0.077157915,0.028904002,0.06526571,0.0027157837,-0.030430948,0.031099094,-0.01779005,0.07499448,0.013537007,-0.058553535,-0.009453667,0.04495013,-0.08593955,0.0052456874,-0.06386613,0.06485315,-0.07769112,0.07924668,0.03081527,-0.025834527,0.1445378,-0.08552862,7.086375e-34,0.110755585,-0.028547363,-0.04891044,0.008865578,0.018743912,0.0051919348,-0.069628984,0.031458993,-0.013918845,-0.06008263,-0.006053334,-0.0044386885,0.0038053915,-0.009581562,-0.062768966,0.004114513,-0.029260894,-0.0027745755,-0.0047155973,-0.03253829,-0.013189406,0.053281173,-0.033537902,0.06523824,-0.011649701,-0.004433352,0.008455736,0.017383669,-0.012056462,0.013220848,-0.024411138,-0.024276705,-0.10477543,0.03725465,0.034487225,0.05886278,-0.08756769,-0.034303557,0.10749217,0.03173591,0.027703268,0.03886374,-0.0130531,-0.069850825,-0.024424957,0.0007093283,-0.06433092,0.11890115,-0.0266266,0.06341873,0.08772768,-0.06218143,0.030302025,-0.01335624,-0.02350356,0.053039804,-0.06126705,0.012546131,0.07499163,0.07500709,0.0074270754,-0.017678509,-0.029468795,0.012988013,0.023523793,0.014725257,-0.049114097,-0.0024238143,-0.008869511,0.04043662,-0.03315335,-0.017164888,0.10387517,0.0048471093,0.013386089,-0.07729532,-0.03350844,0.042512216,0.0057714684,0.046453144,0.06419338,0.0013488134,0.030515863,-0.014453606,-0.023651691,-0.0025572588,0.04523592,-0.14346068,-0.005380313,-0.004869271,-0.064922355,-0.028540418,-0.014316719,0.02667845,0.044611845,-2.0296585e-33,0.08489168,-0.12676986,0.017895753,-0.024323564,-0.0144955935,-0.014968651,0.09408097,-0.025201654,0.03662901,-0.01066005,0.07733073,0.03985302,-0.048876554,-0.08557391,0.08250935,-0.055521462,0.09317828,0.064071245,0.023467856,-0.021802824,0.0071915276,0.06557928,-0.07002957,0.046178486,0.12722057,0.0011279621,-0.009884686,0.061408143,0.013276168,0.08900335,-0.033900917,-5.172372e-05,-0.013597088,-0.064865656,-0.027233647,0.115602635,0.0091235945,0.006955392,-0.06089458,0.017261006,0.03706082,0.0069296034,0.036427118,0.057667,0.06622129,0.038984705,-0.09567666,-0.018137908,-0.06153962,-0.035801105,0.02580023,-0.065900244,0.0044839946,-0.0077486164,-0.02886159,0.13283522,0.057096083,-0.054592296,0.015237862,-0.06304816,-0.05383773,-0.022378253,-0.0116638765,-0.038606007,-0.009714927,0.031130696,-0.01138044,0.00689408,0.09742915,0.04333921,0.016690847,-0.056389574,0.059043393,0.05351868,-0.054281257,-0.07627639,-0.050210163,-0.011175408,0.015048225,-0.043347586,0.022328908,-8.000637e-05,0.01512159,-0.05176022,-0.0138837425,-0.066578515,-0.013712177,0.13634273,0.0039977906,0.029867826,-0.027060699,-0.025789112,-0.026150202,0.05071681,0.06968661,-4.1912436e-08,0.024190672,-0.074029446,0.0012494166,0.01526284,0.050801013,0.033914182,0.02419274,0.031889137,0.03643605,-0.07689925,0.01371517,0.06805985,0.023274945,0.023410391,0.0016642505,0.04990218,-0.016605737,0.07121715,-0.0768589,0.029862532,-0.05397586,0.04050896,-0.029575977,0.015985467,-0.034496672,-0.050561383,-1.4950113e-05,0.07618947,-0.00502807,-0.020681996,-0.010835748,0.029878972,0.08967819,-0.046607144,-0.01974789,0.00013299292,0.042425957,-0.041077293,0.010573349,0.030349221,-0.008038906,-0.0033383172,-0.01755844,0.019474348,-0.013461499,-0.047429685,-0.056006804,-0.0026231788,-0.03478116,0.025483787,0.04956865,0.0028144615,-0.021334752,-0.020336919,-0.02913843,-0.044942822,-0.007243764,-0.06833342,0.05191748,-0.057303447,0.022682548,0.1087114,0.18553632,-0.028484305 +3.5.1.65,Also acts on other N-alkyl-L-glutamines.,384,1.0,-0.03467584,-0.13935006,-0.025004964,0.0259998,0.03995856,-0.0029096091,0.0362111,0.01779481,0.06076574,-0.0357946,0.016686583,0.064157695,-0.015869297,0.067294866,-0.022620592,0.07571082,-0.029630922,-0.0388543,-0.04387159,-0.04071488,0.046894945,0.07117579,0.012395157,-0.0615162,-0.015940152,0.04398948,0.04868387,0.018943718,0.07868216,-0.07289635,0.016371548,0.0034658469,-0.026984753,0.0009440377,0.02270661,0.0334558,-0.100935295,0.015380557,0.053883735,0.022321444,0.04589439,-0.05244612,-0.011415973,-0.041717228,0.021620125,-0.0093818195,-0.0008049546,0.03103959,0.041829824,0.0916381,0.019161275,-0.07520835,-0.00938557,0.09378139,-0.01814119,-0.0029253773,-0.21771732,-0.014897797,-0.011606243,0.014862859,-0.060903642,0.023863012,-0.015252474,-0.027502574,0.04139989,0.022525704,0.048216984,-0.034152236,0.011715523,-0.0019409533,0.00031386717,-0.02623642,0.035050783,0.025862688,-0.010386794,-0.04815898,0.0012930061,-0.026855798,-0.009632801,0.017329412,0.028899733,0.036869366,0.03797393,0.094013706,0.0016678895,-0.031407885,-0.06119251,-0.007877466,-0.003637794,-0.017579941,-0.0064401287,-0.06335623,-0.01204151,0.025113259,-0.004953727,-0.038401704,-0.025440568,0.028316606,-0.06501563,0.01501012,-0.07533048,-0.0022935118,-0.026660563,-0.039804958,-0.029459404,0.059043683,0.055202503,-0.004775003,-0.039747287,-0.022985768,-0.03640619,0.028158013,0.006383591,-0.004877643,-0.11348248,0.020951374,0.045897696,0.008163074,-0.06894301,-0.060929544,-0.0010123679,-0.034307327,-0.019521035,0.040855803,-0.06357963,0.09380062,-0.00475812,-1.4956974e-33,0.03425509,-0.022309829,0.0024815563,-0.030983876,0.050067857,0.023556115,-0.09954883,-0.0331809,0.07088629,-0.027728288,-0.07042997,-0.010403006,0.05337686,0.018584762,-0.017778369,0.03603961,-0.019297486,-0.0040711807,0.055947013,-0.054344714,0.018533343,0.11366629,-0.060533173,0.012856063,-0.106779754,0.054274693,0.025403593,-0.007334788,-0.0039839568,-0.037460484,-0.011801859,-0.021401051,-0.03738558,0.043669432,0.021179494,0.12999578,-0.06652907,-0.027021008,0.039273076,-0.010129819,-0.029817043,0.046377752,-0.09435036,-0.012783769,0.01512781,-0.018623712,-0.11287933,0.046024416,-0.0073005585,0.048481684,0.11106491,-0.064420104,0.04603301,0.0027633389,-0.031163435,0.0064374125,-0.03442871,-0.04388512,0.017592506,0.10268965,0.012851996,-0.03494045,-0.0047095846,-0.039085835,0.025179772,0.028923465,-0.053201437,-0.018420123,-0.023477701,0.020349301,-0.053711902,0.023550354,0.093341306,0.073793925,-0.029592466,-0.089076646,0.0048778867,0.030884057,0.057040755,0.05678899,0.06639374,-0.060218755,0.079965994,0.019216701,-0.078030564,-0.028939048,-0.025958197,-0.14134273,-0.0072958437,-0.031000234,0.037380796,-0.035805546,-0.033510193,-0.004803744,-0.017029677,-7.2626284e-34,0.057907134,-0.08305263,0.0028268094,0.031876538,-0.023757312,0.021556035,0.022861866,-0.01885029,0.01355115,0.057406865,0.07372766,-0.011847549,-0.062172372,0.020130778,0.04217133,0.011095257,0.014365153,0.089722626,-0.021597208,-0.05353462,-0.04156431,0.09395346,0.052376196,0.07524253,0.043110646,0.014819811,-0.009821516,-0.0136854425,0.0052781496,0.07635449,-0.0027265933,-0.023633206,-0.062093735,-0.097210266,0.06919496,0.044552814,0.020742957,0.027366366,-0.08985951,-0.09208103,0.042496856,0.017703038,0.09532537,0.08859693,0.01890442,0.0805711,-0.04800604,-0.058158286,-0.1762243,-0.03352353,-0.010315267,0.025110263,-0.043972094,-0.0026228626,0.060770176,0.12599646,0.06385653,-0.07094702,0.023773108,0.011130475,-0.018033307,-0.0048367837,-0.062982254,-0.07043077,0.05721482,-0.022709904,-0.022213966,0.038292557,0.08017882,0.018145451,0.059780426,-0.045465592,0.008631407,0.010605981,-0.106223725,-0.033421922,0.0015579491,-0.104541935,-0.030572241,-0.08062812,-0.022862336,-0.02202593,0.048786666,-0.023498978,-0.057621967,0.029835828,0.02130475,0.096437186,-0.016230326,0.07814379,0.0072845453,-0.036285203,-0.049697876,0.07126711,0.02332332,-2.2748354e-08,0.029072419,-0.02104324,0.020138841,-0.032476936,-0.050993375,0.050046053,0.009364732,0.06834348,0.008972717,-0.035398327,0.010414846,0.089106716,-0.004544093,0.013462412,0.0074335826,0.027261835,-0.039506126,0.017596195,-0.055088732,0.004322502,-0.13224913,0.01585269,0.0075604557,0.03198905,-0.021061638,-0.08615809,0.016249657,0.10323276,0.048811954,-0.029053599,0.035711203,-0.013310749,-0.00092507846,-0.109516725,-0.044792533,0.030623563,0.067630365,-0.041509308,0.03617689,0.03158984,-0.05108931,0.017011164,0.027791211,0.042650208,0.0079637,-0.049103767,0.025067138,-0.03408801,0.0016681865,0.06707923,0.041401643,-0.036419388,0.011045494,-0.029405104,-0.12455903,-0.028204815,-0.07041332,-0.020815328,0.13027422,-0.04386334,-0.017546892,-0.012683972,0.098152414,0.07631559 +3.5.1.66,Involved in the degradation of pyridoxin by Pseudomonas and Arthrobacter.,384,1.0,0.0048820344,-0.0575199,-0.042737745,0.00077326235,0.059208263,0.05406134,-0.05565735,0.07192561,-0.028412813,-0.010242993,0.044777256,0.00014059951,-0.047343872,0.11109844,-0.00278413,0.07124864,-0.065031074,9.629896e-05,0.044500332,0.049995348,0.015871504,0.046949904,-0.056968324,0.035977267,-0.029993618,0.067250334,0.05972915,0.0056638704,-0.06666581,0.023770982,-0.05342835,-0.060179945,0.043203544,-0.10088297,0.06817369,0.045120735,-0.075436436,0.020365525,0.11424738,0.010932705,-0.010585537,0.011405341,-0.092141494,-0.061381653,-0.02403282,0.054041117,0.019105045,0.034672923,0.076061904,-0.0638468,-0.06733387,0.02701075,0.017705286,0.055721354,0.038749993,-0.052465823,0.026907282,-0.032319102,-0.06989373,-0.018878186,-0.03352706,-0.015341847,0.046958677,-0.01100149,-0.048258077,-0.0056558573,-0.002508962,0.026909802,-0.005256023,-0.019668272,-0.06548753,-0.014429403,0.05106448,0.034159653,0.033073615,-0.009752349,-0.029513188,-0.06647751,-0.04102586,-0.012372539,0.0027215693,-0.063106224,0.011155111,0.05356488,0.031230519,-0.022381242,0.006466915,-0.053584997,0.018174838,0.018963818,0.06890857,0.06018812,0.04341042,0.001011951,0.018433036,0.035881337,0.021545762,0.10191663,0.013622741,-0.07210249,-0.066099025,-0.014063173,-0.1300153,-0.107631065,0.0383491,0.015012137,0.046799347,0.049706116,0.058996424,0.03665778,0.007751703,0.034261834,-0.059693173,-0.08037193,0.037951533,0.025486212,0.083654985,0.001686092,-0.059849724,0.06607264,0.005112778,-0.03637197,0.02913498,0.039500974,-0.0004828172,-0.07094672,-0.03265996,-6.7173974e-34,0.00028270364,0.030529177,-0.049915224,-0.026102856,0.06795738,-0.030366335,-0.018404214,-0.08226459,0.054826677,-0.019222703,-0.00042587335,-0.042842865,-0.044658933,0.014059557,-0.003686043,0.037984293,-0.085608155,-0.0010462274,0.054260638,-0.001422418,0.08216061,-0.015774641,-0.04997282,0.049298637,-0.023017885,0.098267026,0.032099947,0.017776944,-0.121330835,-0.034239996,0.07184366,-0.022381758,-0.13502535,-0.04029887,0.033488784,-0.042395044,-0.04471821,0.011546456,-0.11250883,-0.03018559,-0.039906476,0.010931847,-0.041982964,0.0005219898,0.08268718,-0.06584433,-0.084693976,0.19053411,0.012099218,0.04527655,0.017564647,-0.07088594,0.061175223,0.052300937,-0.05594592,-0.04597609,-0.0012979611,-0.11832525,0.051824782,0.008962817,0.105935,0.0383618,-0.021732658,0.044984926,-0.0040870775,-0.043188266,0.053454522,0.0061259377,0.028989457,-0.011555533,-0.05548012,-0.040679146,-0.042520702,0.025978168,-0.060798593,-0.05499966,-0.09203694,0.0138715925,-0.036595304,0.013439035,-0.012692968,-0.022674724,0.057784855,0.016357768,-0.009755383,0.02751896,0.027415182,-0.017710786,0.010816631,0.025429705,0.05095133,-0.10031272,-0.04788555,0.06303084,-0.07402758,-4.3930956e-34,0.05957619,0.0018576739,0.02845158,0.0049767536,-0.03306299,-0.019862974,-0.023101011,0.15840144,0.024945904,-0.0111072045,-0.0008949695,0.013968015,-0.014000974,0.035625838,0.044121005,0.05613712,0.026263215,0.008062391,-0.010561603,-0.018997664,-0.010169016,-0.008159635,-0.07254918,0.013463877,0.032443542,0.056365747,-0.018662063,0.0987126,0.044900287,0.022243321,0.04336281,0.08582391,-0.030825026,-0.031519763,0.007711398,0.028176822,-0.064699516,0.0040289527,0.09175687,-0.00068612344,0.12434187,-0.02419253,-0.056965463,0.017634034,-0.052389577,0.04471566,-0.058438122,-0.02291813,0.061177634,-0.053128902,0.018199505,0.0041241427,0.013758582,-0.038995046,0.0012677134,0.01425404,-0.0043584937,-0.009682873,0.0036106242,0.013746121,0.026580054,-0.029512243,0.020190043,0.07879541,-0.04637015,0.0662739,0.06541814,0.037062354,0.003938916,0.04429396,0.029766697,0.06750087,0.033490926,0.037904315,-0.11871603,-0.027512277,-0.025366388,0.06366399,0.0861646,0.07564986,0.054263704,-0.030113518,0.0057755746,-0.09987681,0.003945091,-0.061128855,0.000954872,0.082113504,-0.065845266,-0.028705388,0.056493744,-0.061281703,0.05960875,-0.022680145,-0.013728001,-2.301916e-08,0.03894859,-0.018602079,0.07135051,-0.010324533,0.016543586,-0.0054989425,0.033709694,0.0234358,0.010851368,0.0030833196,0.012911626,0.0071075554,-0.0069690878,-0.031634815,0.051148195,0.010883367,-0.036740053,-0.0049574254,0.012507878,-0.035524208,-0.082622394,-0.040283006,-0.07995301,-0.042932943,0.052787904,-0.0025802117,0.054824673,-0.04641074,-0.031387955,0.033259515,0.0013855795,-0.0036118615,0.016756654,-0.023032837,-0.09065534,-0.02485526,-0.08114114,-0.083368994,-0.029383874,-0.03927278,-0.074669406,-0.018923268,-0.10733653,-0.018751437,0.0855525,-0.025134578,-0.046372525,-0.03711241,-0.037633065,-0.051859643,0.15498716,-0.009360098,0.02385372,-0.04173231,-0.13262813,0.07114331,0.0633369,-0.00035664544,-0.07621735,-0.06937852,-0.018619582,-0.029904714,0.06425173,0.018443838 +3.5.1.68,The animal enzyme also acts on beta-citryl-L-glutamate and beta-citryl-L-glutamine.,384,0.99999994,-0.054512456,-0.08408511,0.009266193,0.015726082,-0.00039502548,0.05684212,-0.016666736,0.0041616648,0.07598175,0.023183595,0.0034924592,-0.022788513,-0.022846464,0.08714088,0.001033851,0.011505775,-0.076576024,-0.028919246,-0.044961896,-0.09476041,0.026027055,0.07059896,-0.09374709,-0.052241325,0.01582317,0.03152325,0.04282928,-0.07034203,0.034366053,-0.04869486,-0.042105768,-0.05417213,0.036212984,0.04624028,-0.008965564,0.029501526,-0.1220554,-0.12940523,0.10657779,-0.00082614814,0.013936729,0.038986247,-0.023760859,-0.03727283,-0.054731082,-0.023019098,0.0032855836,0.010224728,0.047275223,0.0160745,-0.027834298,-0.07326507,-0.0004813697,0.03448554,-0.0076582865,0.015618106,-0.08947443,-0.022663726,-0.023097167,0.050176546,-0.048494037,0.038496982,0.002597632,0.0145223085,0.016345551,-0.024805857,0.023254873,-0.0027945612,0.025574861,-0.10859594,-0.021227373,-0.07814015,0.07698604,-0.03759024,0.015555316,-0.0464988,0.021712003,0.013988728,0.019050878,-0.03008887,0.020259053,-0.024391826,0.05639574,-0.0059554484,0.06468953,0.022923704,-0.043237507,0.036433205,0.009054752,0.022568258,0.057345103,-0.0693689,-0.10214594,-0.008998454,-0.012688862,-0.0107603865,-0.029999526,-0.054468077,-0.01650371,-0.018065663,-0.02897593,0.064899415,-0.00711533,-0.030529097,0.015027985,0.038923874,0.040245175,0.04490423,-0.04037589,-0.0037585518,-0.024329573,0.041236356,0.040289875,0.08751772,-0.016648838,0.06398207,-0.009594394,-0.03732763,-0.025966814,-0.0363007,0.056832127,-0.028348858,0.011830684,0.038853865,-0.08247001,0.08669641,-0.056040093,-2.0446793e-33,0.038767327,-0.041026186,-0.021597592,-0.04427885,0.042435095,0.019926917,-0.10124838,0.044194322,0.028875267,-0.022867171,-0.046236254,-0.060261354,0.02079524,0.02371933,0.0697347,0.037697457,-0.05110259,-0.031194445,0.11066747,-0.027338123,0.0076301373,0.03460796,-0.02406754,0.017258173,0.010608446,0.07589016,-0.026814071,0.0596164,-0.008054098,0.00563537,-0.022086134,-0.121308446,-0.034971297,0.03593615,0.020125628,0.06371541,-0.027540574,-0.05429169,0.010369245,0.071510404,0.05498858,-0.051379748,-0.06301976,-0.00072095846,-0.0039161486,-0.031108545,-0.10195046,0.035922814,-0.017545568,0.034979675,0.07662279,-0.062859766,0.116249435,-0.01332414,-0.058609422,0.10645242,-0.014949829,-0.09738186,0.02862918,0.047886606,-0.017484345,-0.0121158045,-0.023390407,-0.004530158,0.117624484,0.045729566,-0.08758783,-0.07922919,-0.032093853,0.068706855,-0.0634775,-0.008314477,0.009205543,-0.022009164,-0.01749254,-0.059477147,-0.048062205,0.030545857,0.015011508,0.010468496,0.019522363,-0.0027369026,0.006500792,0.0099802725,-0.009564204,-0.019883418,0.06929364,-0.058078364,0.019464396,-0.055720177,0.038009647,-0.014308734,-0.03317479,0.021073265,0.056586772,-2.4216036e-35,0.065924585,-0.105081126,0.035872553,-0.0042215427,-0.046477396,0.03752033,0.028336108,-0.08082746,0.011510896,0.060498513,-0.025755746,0.027308008,-0.06254864,-0.040291168,0.020540647,-0.0060759303,-0.026152963,0.023405623,-0.023599844,-0.040104873,-0.008090487,0.053055383,0.09071593,0.010570254,0.06309982,0.0072321435,0.0025881296,0.01978911,0.053595223,0.033849064,0.004309972,0.032300677,0.036731865,-0.10572904,-0.0025009736,-0.009134451,-0.0019326877,0.015471544,-0.024202501,0.008850355,0.07860799,0.093827076,0.008012411,0.07160161,0.04708219,0.12726803,0.0032184727,-0.05783806,-0.1266212,-0.06593808,0.06134838,0.014332916,0.022271095,-0.05945029,0.05889703,0.036706924,-0.00590653,-0.04547705,0.05519091,-0.043642104,-0.036944456,-0.071067385,-0.023334669,0.006396471,0.055394642,-0.045320738,0.070978224,0.03278618,0.06779078,0.008490453,0.044826977,-0.008196787,0.011274806,0.024013514,-0.076338135,0.008895223,-0.078427576,-0.043004923,0.08149067,-0.088565476,-0.011112376,-0.017563289,-0.009554173,-0.054597512,-0.027822966,-0.06488838,-0.035645623,0.21265768,0.1051514,0.023634987,-0.07642293,-0.002803646,0.003438052,0.034831326,0.07974034,-3.0078905e-08,0.0041547925,-0.042913754,-0.006637878,0.00831821,0.0103741465,0.04244739,-0.0075564147,-0.008769698,0.042904418,0.0076690475,-0.012060071,0.06070039,-0.043520775,0.04432577,-0.0752663,0.060775973,-0.0056111054,-0.00041805446,0.025632286,0.043791052,-0.07709249,0.039102163,-0.042699825,0.036413096,0.02870798,-0.10424594,-0.014659587,0.13516799,-0.040631834,0.018750554,-0.07516877,0.06291123,0.036690604,-0.13431813,-0.06058628,-0.0024603945,0.086510286,-0.05527063,0.045445092,0.0112788705,0.01704665,0.04152876,-0.004074772,-0.023443695,-0.033932697,0.009662495,0.08667272,-0.019612664,0.050116282,-0.05102517,-0.0024880613,0.016433764,-0.027165432,-0.02509467,-0.13795185,-0.0035061939,-0.075527854,-0.07223636,0.038421713,-0.074634336,0.04603969,0.049847577,0.10752464,-0.012645106 +3.5.1.69,Does not act on sphingolipids such as ceramide. Not identical with EC 3.5.1.23 ceramidase.,384,1.0,-0.048210423,-0.12290043,-0.050100744,-0.07067851,0.0747312,-0.03193999,-0.020534387,0.054001234,0.03433492,-0.08539208,0.092788234,-0.13923359,-0.049568135,0.019702274,0.04102454,-0.01998967,-0.00223768,-0.024400016,0.015904611,-0.060542267,0.013040657,-0.0075402968,0.01930871,0.045116648,-0.0886649,0.034776907,-0.008865927,-0.034165584,0.019093473,-0.059302166,0.07404551,0.0068756877,0.0015997983,-0.06938772,-0.0043055397,0.016654762,-0.059565876,-0.036912166,0.016239656,0.0011720692,0.07616373,-0.0068956898,-0.018191544,-0.061165977,0.01579192,-0.013578194,-0.049304646,0.06847542,-0.037401177,-0.013909016,-0.02227036,-0.121536255,-0.015537633,0.009218831,-0.11268575,-0.0073007774,-0.1357519,0.03270812,-0.0059758984,0.008276398,-0.01737692,0.029001605,0.034450993,0.03851693,-0.030552883,-0.0099463705,0.03426534,-0.13820995,0.017764157,0.036511462,-0.017545534,-0.08872547,0.08263325,0.07808335,0.015245574,0.094170175,0.00998188,-0.03284002,-0.026798015,-0.10012631,-0.07847465,-0.059587725,0.01836191,0.03788176,0.0623538,-0.0072118035,0.00819613,0.0071759424,-0.018550813,0.026947621,0.10215388,-0.016590392,-0.010440717,0.093376905,-0.07063244,0.035640195,-0.022280049,0.08181818,-0.054219984,-0.031526644,-0.010479806,0.07300107,-0.08392788,-0.015971199,0.003354559,0.033254564,0.027857937,-0.023432368,-0.1086326,-0.0042775273,0.02273135,-0.07578101,0.087360695,-0.02622664,-0.0454336,0.030089676,-0.046346538,-0.01643498,-0.0023621954,-0.0031835532,0.054603294,-0.030882323,-0.0149574755,-0.033408284,-0.096709244,0.027999602,-0.0024100991,2.0364744e-33,0.010835789,-0.0372199,0.039268747,-0.030614097,-0.08076798,0.0018767704,-0.119741574,0.041538954,-0.049027167,-0.010326779,-0.015678633,-0.039514903,0.05434541,0.0016461631,-0.026553003,0.011159185,-0.024017842,0.046463404,0.048424516,-0.010943859,0.04852556,0.00140452,-0.045972526,-0.064254455,0.04550977,0.05386699,-0.06497604,0.017373638,-0.003976984,0.037398655,-0.05066791,-0.056760695,-0.044147827,0.040144686,-4.1688658e-05,0.09706237,0.048924405,-0.03284373,-0.06054242,0.0131087955,-0.0023591584,0.02683063,0.0043642307,-0.062649585,0.002508133,-0.016139055,-0.06556899,0.07026743,0.08830038,-0.044175465,0.023680005,-0.07530209,0.09215346,0.048214108,0.08842239,0.018064234,0.008429827,0.056498315,0.014131794,0.019990617,0.023636885,0.054691434,-0.071998484,-0.037230343,0.05267836,0.06835023,-0.06165381,0.012538617,-0.10623033,-0.07106011,-0.0045595635,0.04605209,0.10965954,0.07551976,0.017346554,-0.030133959,0.020696627,0.004356138,-0.0032997834,0.041279893,0.007038605,-0.06211258,-0.009713015,-0.04516486,-0.008599119,0.08452295,0.0029412685,0.049029,0.007406665,-0.018984944,0.06945565,-0.06808425,-0.0021471751,0.05108925,-0.083056934,-2.8720523e-33,-0.08452181,0.012704294,-0.011265408,-0.05351512,0.0257103,0.080103435,0.025557764,0.049647525,0.10007301,-0.012129799,0.038302496,-0.007958084,-0.027881935,-0.083980255,-0.03035186,0.09891865,-0.042444505,-0.002520543,-0.006931627,-0.04381038,-0.02045583,0.085759886,-0.03619751,0.13131234,-0.035189122,0.084371164,0.0019409632,0.04106836,0.029076139,0.022505889,-0.017166968,-0.029016173,-0.059147064,-0.012151052,-0.0059292996,-0.041320756,-0.03292384,0.017819833,0.05025198,-0.03221732,-0.07176126,0.088397786,0.027159017,0.035918728,0.104916394,0.10816551,-0.0107241105,-0.025238642,-0.025267458,-0.011212493,-0.06381501,-0.0012601832,-0.012725867,0.033984005,0.028185727,0.038693488,0.006625396,0.05252557,-0.044410862,-0.061821625,0.00753983,-0.0013403347,-0.012927754,-0.018013746,0.10574612,0.028616386,-0.09327038,0.09970893,0.07204505,-0.019938676,-0.0056303176,-0.0477014,-0.10522059,-0.080970466,-0.013696106,0.006527553,-0.014674203,-0.062125273,0.020982703,0.0006414633,0.06727999,0.030823732,0.07860524,-0.04396324,0.05495326,0.08773346,-0.07792336,-0.017946685,0.06917376,-0.0095243575,-0.025852978,0.010248871,-0.011194189,0.04994199,0.09531163,-2.5186592e-08,0.12005732,-0.016386528,0.026908468,-0.03152121,-0.008386305,-0.043394506,-0.017601026,-0.03474115,0.020226875,-0.035196062,-0.08331969,0.03163649,0.049610224,0.029397089,0.055899896,0.008366218,-0.034127306,0.012681558,-0.0041152975,-0.06739149,0.0008716996,-0.0108072795,0.0265313,-2.693172e-05,-0.00354042,-0.0070349956,0.028397368,0.0019722169,-0.026694177,0.015072257,-0.035338044,0.011931954,0.055328622,0.041954085,0.056688577,0.032996662,-0.027867846,0.019567234,-0.02233621,0.098444745,0.0009443383,-0.10300011,-0.04260196,0.017652286,0.0102366675,0.029282063,0.058766905,0.017944692,0.014715403,-0.043162055,-0.040972084,-0.003228839,-0.02732408,-0.021331903,-0.086640835,-0.036141325,-0.08969526,0.01182573,0.06376951,-0.0918669,0.016395336,-0.0039965683,0.097432286,0.05745669 +3.5.1.71,Hydrolyses a range of L-amino acids from the cinnamoyl and substituted cinnamoyl series. Not identical with EC 3.5.1.14 aminoacylase.,384,1.0,-0.0074202246,-0.1377944,-0.027853578,-0.100874245,0.034013703,0.07858613,-0.024361158,0.03822844,0.040920086,-0.042598374,0.04319416,-0.08037908,-0.022347743,0.04745972,-0.04687417,0.023561712,-0.054541856,-0.11287308,-0.077953935,-0.060728814,0.035610564,0.06635134,-0.098282084,0.046724983,0.059925444,-0.00020755043,0.030900957,0.008277907,-0.0050063552,-0.011817662,0.030531334,-0.092074074,0.0021789144,-0.03066628,0.03388771,0.026018225,-0.12579185,-0.07903205,0.021320991,0.035134338,-0.0030100506,-0.00665788,0.0019110806,-0.07386381,-0.11162496,-0.038284108,-0.0018889663,0.026476812,0.014067476,0.015323813,-0.031060835,-0.07604361,-0.035060193,0.033732638,-0.01784483,-0.025085974,-0.09146718,0.011024946,-0.0653587,0.008348052,-0.007418749,0.057579294,0.0059257452,0.022350207,-0.049306765,0.02331504,0.059703834,-0.073005445,0.072407044,-0.03623941,-0.08555997,-0.100624606,-0.0040748357,0.0358841,0.023175102,0.0030320997,0.006534432,-0.025277302,0.009593027,-0.08881386,-0.023487723,-0.02031603,-0.020838976,0.05138583,0.03108971,0.007877393,-0.012425284,0.031190066,0.09782799,-0.043578338,0.08786199,-0.004098617,-0.011555402,-0.003784274,-0.017354678,0.046529997,0.0021812594,0.016320448,-0.054202754,0.025616322,0.02852811,0.13025373,-0.05499752,-0.09574056,-0.08825066,0.037586,0.038287584,0.032560255,-0.047241904,-0.054702993,0.020230442,-0.055916954,0.015810477,-0.02438449,0.0018218588,-0.021022027,0.055280466,-0.025498554,0.07098229,-0.021234985,0.052513696,-3.8121023e-05,0.14596736,0.046884872,-0.08588449,0.074539915,-0.062107947,-6.3173064e-34,0.016236896,-0.04467649,0.03765457,0.015141102,0.02591068,-0.008813353,-0.1067311,0.08064141,-0.0074510686,-0.062715925,-0.019016467,0.04185538,-0.017822504,-0.05388539,0.04238803,-0.021728694,0.03974852,-0.045898654,-0.00100605,0.060589466,0.008868161,0.07471078,-0.0015197189,0.048996113,0.013939164,0.017381163,0.02313946,0.02888887,0.008535394,0.036337063,-0.07708641,0.005280338,-0.11858958,-0.025801541,0.002122126,0.033747446,-0.051625967,-0.03572517,0.07844818,0.07919423,0.052743394,0.029254833,0.060686685,-0.060804825,0.005639223,0.047585882,-0.03751855,0.09937172,-0.013847228,-0.0629536,0.050816536,0.016818687,0.043654826,-0.009020016,-0.016460095,-0.006008175,0.007566802,0.048785035,0.0820249,0.048215747,-0.05239702,0.064434245,0.0089272335,0.016972933,-0.020585163,-0.02385647,-0.102915175,-0.006624544,0.04739342,0.04083734,-0.074615926,-0.014727472,0.11177575,0.020690514,0.03560138,-0.16386949,-0.063258104,-0.015810737,-0.015949415,0.09560764,0.040257502,0.0061686505,0.010768584,-0.0139365895,-0.037749782,-0.018305928,0.0389731,0.014998678,0.0051583834,-0.003461361,0.01197334,-0.009218473,0.010355537,0.007812572,-0.01822641,-1.9790634e-33,0.086572126,-0.1271562,0.0032958596,0.010345796,0.0021484066,0.00884379,0.08802637,-0.025584873,0.0200702,-0.034519065,0.12507194,0.040151566,-0.04396781,-0.05919446,0.057489157,-0.00026085784,-0.010159359,0.009827795,0.032532886,-0.03844551,0.03205974,0.00018463323,-0.027472777,0.0036483146,0.06528452,-0.00019794663,-0.036632504,0.091338314,0.064125836,0.005812215,-0.022462197,-0.017327754,0.022795377,-0.0835927,-0.072027996,0.0629922,-0.027705263,-0.0067449547,0.0019044466,0.04161345,0.021227475,0.06609835,0.0932045,0.04921563,0.047196608,0.058055446,-0.05382752,-0.0603144,-0.048922885,-0.024828766,0.057056915,-0.061373837,-0.03476162,-0.01643693,-0.007425755,0.053542774,-0.018503115,0.012720579,-0.0039993785,-0.0055868425,-0.06227917,-0.066874355,-0.009729664,-0.0119841825,-0.017425673,-0.0068069035,-0.0666233,0.05018757,0.083546706,-0.022984695,0.015857562,-0.10513444,0.05169645,0.012654207,0.04661441,-0.019357966,-0.062206075,0.01607811,0.012879191,-0.08512017,-0.012254279,-0.0058930367,0.007459352,-0.015957512,0.034621768,-0.09316418,0.048759077,0.074086964,-0.0070990897,0.029035501,0.0010010371,-0.0045653144,-0.015722236,0.06294158,0.13085245,-2.6958139e-08,0.05780103,-0.044963233,0.045699205,0.03324334,0.058808353,0.0004381043,-0.0071566952,0.004576159,0.04976847,-0.034065336,-0.01692286,0.002778694,0.0068338476,0.07415113,-0.046520777,0.097999044,-0.07328608,0.008387049,-0.005411264,0.06536264,-0.04608713,0.04622033,-0.0839805,-0.05409371,-0.06406092,0.0106257135,-0.050240852,0.073982514,-0.10800485,0.030636996,-0.029752504,-0.009030247,0.02658431,-0.0696804,-0.015921261,0.031085962,-0.026357176,-0.057793282,-0.049607605,-0.06924028,0.020005953,-0.07358175,-0.021220118,0.0026217152,0.07270807,-0.055566378,-0.027548552,0.052026164,-0.039141692,0.0170388,0.043110274,0.054755144,0.03537673,-0.0032509523,0.013286249,-0.07106127,-0.0449594,-0.0830318,-0.012419793,-0.082770154,0.02339546,0.011212174,0.13037595,0.017232962 +3.5.1.73,Does not act on D-carnitinamide.,384,0.99999994,-0.023144308,-0.06358832,-0.023791842,-0.047240794,-0.016397892,-0.12576275,-0.017626176,0.04361721,0.02832435,-0.006598366,0.030351413,0.013738342,-0.06334555,0.08008128,-0.061914474,0.0074335774,0.020010035,-0.0073209335,0.05797422,0.08384522,-6.23869e-05,0.024970977,0.060476407,0.040282104,-0.019701395,0.0740708,0.030626066,0.054683194,-0.017171822,-0.06234082,0.00460327,0.023711009,-0.041224062,-0.029782351,0.055430047,-0.03252913,-0.098513246,0.06297524,-0.03564718,0.04146346,0.04135915,-0.006137582,-0.05603893,0.0027623002,0.046292204,-0.028202692,-0.09580209,0.031398915,-0.0004111534,0.07154269,-0.059367094,-0.068730354,0.001433268,0.03780392,-0.059847154,0.008546608,-0.09715557,0.071179435,0.054833405,0.010802434,-0.0062863007,0.015202215,0.035557237,0.015164226,0.04158957,0.01979951,-0.008693488,-0.11665782,-0.002203632,0.025241453,0.032756384,-0.113347076,0.066356085,0.06524285,-0.0051706946,-0.01883038,-0.03604203,-0.053079527,0.040183153,-0.016617341,0.008572979,-0.028583044,0.03731481,0.10250441,0.048290797,0.057276007,-0.01504061,-0.030956477,-0.023706825,0.0003450654,0.007286889,0.0318725,-0.02669524,-0.023494296,-0.08256052,-0.056921363,0.004129701,0.03493652,-0.102217875,-0.014330415,0.004969308,0.039095648,-0.15243733,-0.024570158,-0.100651994,0.023723688,0.015952678,-0.04113309,-0.091159575,-0.019698,0.016760936,0.07385043,0.07083006,0.0312005,-0.114045866,0.026441313,0.031569008,0.013063274,-0.0008324674,-0.030128112,-0.019644791,-0.05563806,0.030023595,0.0043384414,0.023386206,0.041138228,0.048695557,-1.3239416e-33,0.052674264,-0.08496921,0.00063953333,0.0022252928,0.0074201836,-0.010388453,-0.04268373,-0.040042162,-0.018184016,-0.028253857,-0.029311735,-0.07245947,0.02009308,0.03284069,0.032875292,0.076453805,0.049200475,-0.030932583,0.03224945,-0.07525617,0.11044409,0.07398041,-0.06330804,0.038001575,-0.04389734,0.07107153,0.0011401693,0.08309201,0.06432418,-0.0019000034,-0.07962417,-0.01890841,0.036210474,0.024351086,0.003260558,0.103418365,-0.065911986,-0.0060632294,-0.007482016,0.030208612,-0.009426423,0.017912919,-0.010650779,-0.079340145,0.0132693,-0.04939698,-0.001536459,0.01463255,-0.03727326,0.030797357,0.08309223,-0.056698967,0.028473353,-0.019475333,-0.038810052,0.098925695,-0.03738366,-0.02937748,0.013619145,0.016754013,-0.013455399,-0.0014378221,-0.023678558,-0.0011092632,-0.032939155,0.06389412,-0.057392728,-0.067021474,-0.08719675,-0.0513256,0.001300103,0.0027715275,0.12237159,0.032670066,0.024831897,-0.026036892,0.0050326474,0.03978762,0.0042477646,-0.03791265,0.014656412,-0.11454096,0.041865215,0.04217245,0.03929123,-0.03909643,-0.04423703,-0.042956583,-0.064845644,0.027319405,0.041534334,-0.109028906,-0.05499614,-0.006334629,0.02931626,-7.312039e-34,-0.0443444,-0.009584818,0.077097096,0.0073777693,-0.052416336,0.11985641,-0.0023914932,0.013715716,0.11850029,-0.093784146,0.07179751,0.07077631,-0.07726972,-0.03391085,-0.02534759,0.06812752,-0.014100386,-0.011022945,-0.115377195,-0.03491625,-0.005295051,0.032437675,-0.016897548,0.082878545,0.04363387,0.026213521,0.023401113,0.041470796,0.060523503,-0.031532157,0.086202465,0.031069536,-0.09268579,-0.07771935,-0.010781423,0.057720173,-0.039307054,-0.03171107,-0.11195344,-0.026391214,-0.067595676,-0.024603695,0.018838543,0.044000365,0.044634413,0.024686897,0.017016325,-0.044393107,0.056253813,0.031132206,-0.002087443,-0.02348854,0.049911495,0.045155145,0.07722234,0.054088503,0.12493305,-0.011414197,-0.06696247,0.064378254,0.0949925,0.012799395,-0.028644519,-0.039471935,0.049343213,0.015590639,-0.046283286,0.11875857,0.14998116,-0.045963477,0.09415468,0.02082464,-0.0029591934,-0.011144248,-0.08313435,0.014329639,-0.019593664,-0.020367797,0.05576887,-0.0443608,0.016128568,-0.020006062,-0.010673476,0.0405959,0.008627791,0.008128472,-0.017396225,-0.035737623,-0.023435263,0.07218695,-0.0062420387,-0.0050817216,0.023035524,0.041787155,0.0500483,-1.6943316e-08,0.09832349,-0.014059628,-0.004033381,-0.07586833,-0.03511292,-0.031918216,0.015624523,-0.03756408,-0.010020851,-0.0405112,-0.021954367,0.060445722,0.011959875,-0.0003219591,-0.021197563,-0.0123556685,0.060170382,-0.004971367,-0.05953674,-0.01596977,-0.14626509,-0.0070595834,-0.086225815,-0.014499764,-0.03785888,-0.03685984,0.10320271,0.023207184,-0.0011447213,-0.016343992,0.008808036,0.02586279,0.026355773,-0.0008194446,-0.051525086,0.006012212,0.031639546,0.028695464,-0.018705832,0.011159088,0.0025104734,0.021959757,-0.0044415416,0.061594956,-0.061630335,-0.021105105,-0.018689118,-0.042015243,-0.029522914,0.040400837,0.034789037,0.068542205,-0.077209316,-0.06371468,-0.07921497,0.013060285,-0.0047937925,-0.0048539755,0.020921582,-0.121181056,0.01059924,-0.081875935,0.046036642,0.075357154 +3.5.1.74,"Some other taurine conjugates are hydrolysed, but not glycine conjugates of bile acids.",384,1.0,0.069220155,-0.113356926,-0.012318915,-0.058583647,-0.03586038,0.021469342,-0.02694578,0.011917401,0.020953793,-0.049522072,0.0064770356,0.07560544,0.022643438,0.02321789,-0.025889885,0.05026205,0.046092875,-0.025791975,-0.06624706,0.019675162,-0.034656607,-0.03475885,-0.03315403,0.02805037,-0.0033026515,0.022927146,0.052371696,-0.02381357,0.022262847,-0.0341882,-0.049604222,-0.051258788,-0.041567046,-0.059742283,-0.07474993,0.0103627965,-0.059461925,0.07976433,0.08057608,0.011334073,0.09243366,0.025627531,-0.004617481,-0.04900804,0.021742463,-0.02409601,0.029504817,-0.030760556,-0.007984315,0.06248268,-0.04340896,-0.0118344,-0.05099881,0.043132115,-0.024020234,0.054423172,-0.10158943,-0.043197267,0.019279609,0.023891179,-0.062470537,0.025193244,0.0070783226,-0.0063648704,0.00032589977,-0.04440532,0.029532185,0.020344377,0.06271493,-0.00994381,0.03228699,-0.005792112,0.03847577,0.011406997,-0.05174597,0.055917345,-0.046346832,-0.011766387,0.06706031,-0.048330907,-0.034709822,-0.08869457,-0.017356133,0.062349096,0.11170088,-0.010634115,-0.0058908733,-0.025393188,-0.04210964,-0.00777112,0.026820492,0.0149432765,0.040286154,-0.092040144,0.023393022,-0.041027837,0.00529577,0.035697676,-0.055492863,-0.03519301,-0.021297004,0.07152493,-0.005988242,-0.056556966,-0.06608285,0.00036773135,0.03318319,0.016089529,-0.01941763,-0.010948303,-0.025107922,-0.033453744,0.07340587,-0.037010305,-0.0072337547,0.13256785,0.017501418,-0.05313407,0.024470067,0.011492182,-0.023223523,0.004315045,0.11551716,0.02741373,0.016173491,0.04520928,0.070886225,-2.6340223e-34,0.042105787,0.007883573,0.036435798,-0.025450936,0.0049803806,0.006658015,-0.11890231,-0.058004215,0.020125959,-0.049890038,0.04845918,-0.010060794,-0.019924473,-0.034056596,0.028846614,0.01965434,0.020153984,-0.024825074,0.0411341,-0.04652334,-0.004013826,0.12260141,-0.037933476,-0.06363313,-0.04703805,-0.060948182,-0.020689787,0.024869334,-0.028076336,0.035962723,-0.0071878713,-0.041679293,-0.060974777,0.107428424,-0.044559143,0.06449165,-0.09347075,-0.066985786,0.05035529,0.06797134,0.055245783,-0.040103614,0.022405863,-0.017643197,-0.0030128707,0.004717816,-0.020899352,-0.029702956,-0.040476985,0.005189781,0.058527984,-0.027515592,0.022388076,-0.083485395,-0.022415843,-0.04329172,0.084361,0.021655662,-0.0020695582,0.13892885,-0.0458056,0.08271655,-0.05569013,-0.024170298,-0.036775548,-0.039727848,-0.106514685,-0.017685728,0.029469404,0.039794452,-0.0068724183,-0.028554073,0.073911615,0.052095577,0.00059696403,-0.044203002,0.027220167,0.046229385,0.0067266608,-0.010550488,-0.0032102284,-0.0056929886,-0.07272255,0.07685453,-0.05691954,0.047964867,0.04977818,-0.09320137,-0.010515017,0.021692308,0.00089412986,0.026398571,-0.04807798,-0.0069957515,-0.0092774285,-1.4701714e-33,-0.04079684,-0.0906545,-0.0003152882,0.046398267,-0.018146249,0.056806024,0.064763114,-0.05813959,0.038207393,-0.08667555,0.073102176,-0.0074407416,-0.09799795,-0.02224995,0.0029707449,0.0037559143,0.06394823,0.058602303,-0.013646443,-0.094374366,-0.042779036,0.03595432,0.038228896,0.10652559,0.018759253,0.047448646,0.046876438,-0.029210486,0.13663374,0.12793721,-0.013023675,0.059890676,-0.021296233,-0.022971215,-0.060689658,-0.03193606,0.012189606,-0.0074622836,-0.055816274,-0.067074426,0.014115426,0.037083272,0.061301358,0.03947188,0.007368563,0.071041055,0.010366257,-0.0040720575,-0.048501324,-0.0062338333,0.08134642,-0.09648732,0.0034088132,0.031704485,0.004314226,0.041917365,-0.0054444256,-0.045454923,-0.0050162636,-0.07948804,-0.057861365,0.04526536,-0.012239662,-0.13853109,-0.0023878843,-0.001819816,-0.023085095,0.04516911,-0.017163444,0.026474273,-0.0149314115,-0.028476426,0.0627568,0.07938617,0.038425736,0.0639956,-0.016671037,-0.03775483,0.017986147,-0.08068511,-0.02407006,0.055526868,-0.058432158,-0.048194792,0.04281344,-0.045163825,-0.08008198,0.11015748,0.07071836,0.056224346,0.0037012207,0.0023399603,-0.047738627,0.030110588,0.02157899,-2.0599872e-08,0.07746834,-0.039881505,0.04198908,0.054585226,-0.10591419,0.0704722,0.026837735,-0.078464426,0.03070795,-0.015354015,-0.061461333,0.10275547,-0.01001296,-0.054466818,-0.10235053,0.12555577,-0.07689347,-0.033237044,-0.020837253,-0.022273362,-0.1252197,0.030621333,-0.06639883,0.011848494,-0.041282017,-0.012737248,-0.022933055,0.0013698646,-0.032505784,-0.017841863,0.089210905,-0.024420826,-0.013403369,-0.05181232,-0.00938351,-0.022359943,0.057977173,-0.01218089,-0.0040274775,0.013971709,0.014623455,0.0017645694,-0.055754185,0.045877643,0.038038578,-0.03071249,-0.03653126,0.045853753,-0.017338961,0.050153386,-0.010063859,-0.008858011,0.06451465,-0.06885103,-0.051760077,-0.052558515,0.0031916895,-0.07905883,-0.017528301,-0.06893723,0.0015364259,0.03057777,0.21075687,0.065544754 +3.5.1.76,"Identified in Pseudomonas putida. Strict specificity for N-acetyl arylalkylamines, including N-acetyl-2-phenylethylamine, N-acetyl-3-phenylpropylamine, N-acetyldopamine, N-acetyl-serotonin and melatonin. It also accepts arylalkyl acetates but not acetanilide derivatives, which are common substrates of EC 3.5.1.13, aryl acylamidase.",384,1.0,-0.028153105,-0.11890903,-0.06785969,-0.033225827,0.0041927756,0.11010931,-0.03613671,0.017284475,-0.012792722,-0.031858757,0.06728699,-0.059917536,-0.09848641,0.09636156,-0.024350636,0.07685304,-0.03157056,-0.047247533,0.0582449,0.003507111,0.014403542,0.08511155,-0.042710613,0.035382435,-0.022667695,0.035735123,0.010640579,-0.017960321,0.008584252,-0.024106985,-0.042679675,-0.08217284,0.057742957,-0.052604996,0.09498521,-0.011710605,-0.052716415,-0.026446804,0.11056236,0.045867875,0.013332239,-0.0016368959,0.0061694686,-0.07431751,-0.025815904,-0.043484423,0.064784095,-0.014887535,0.01897279,-0.022475436,0.008086959,-0.030487863,0.061496202,0.07087923,0.0042509744,0.04741122,-0.041762717,-0.047755007,-0.011562326,0.0378645,0.0024639042,0.024138445,0.0046739415,-0.06561708,-0.027012875,0.032645203,0.031157505,-0.07170179,0.08133073,0.027099226,-0.038434256,-0.042737227,0.08845991,0.039109178,0.012806658,-0.0097745815,0.005753099,-0.08505983,0.026698625,-0.06475893,-0.048555695,-0.059182603,-0.021493671,0.0809544,0.054304216,-0.07906266,0.013573514,0.08954445,0.042065833,-0.019825613,-0.014132365,-0.08201649,-0.008819625,-0.03992199,-0.005921557,0.011966776,0.033321206,0.02878961,-0.0154719325,0.027162133,0.025428524,0.011113837,-0.032973256,-0.07674784,-0.025348019,0.02466037,0.038083185,-0.013158283,0.02201541,0.00036006985,-0.038932584,-0.02213535,0.0043220706,0.028140228,-0.046632074,-0.0056283274,-0.0038296406,-0.06058575,0.0137789175,-0.041110676,0.018812303,-0.027357334,0.102840945,0.078148544,0.04197082,0.04625839,-0.117347375,4.9154295e-33,0.04939611,0.043387026,0.025796192,-0.036100503,0.049830034,0.026512785,-0.085331,0.03158337,0.08282996,-0.09650009,-0.021919338,-0.028405365,0.034013093,0.037570383,0.0018173833,0.0063883513,-0.07541691,0.02477074,0.09832522,-0.009173756,0.006458623,0.05607757,-0.068049125,0.027361926,-0.01053861,-0.020425314,0.026869014,0.014705735,-0.026058802,0.012371281,0.04616865,-0.013841249,-0.044366553,-0.020270549,0.054312997,0.057751037,-0.022027066,-0.013813884,0.011909111,0.058896672,0.06776516,0.0970137,-0.016634589,0.012096317,0.017068824,-0.04219566,-0.07843624,0.1409328,-0.036204394,0.05699426,-0.0400553,-0.090542495,0.02713185,0.009859742,-0.0051399623,-0.052055303,-0.086530864,0.013008035,0.10744165,0.002220402,0.026702415,-0.023784803,0.0038235409,-0.055463046,-0.064806186,0.02264775,-0.022660473,0.007314253,0.010462421,-0.015043338,-0.04090641,0.030345032,0.00077640434,0.061164074,0.005358086,-0.107970275,-0.05601078,0.11520551,0.034590367,-0.0005779571,0.00090781023,-0.06593427,0.023891892,-0.008193478,-0.116076924,-0.02386018,0.02419789,0.036173154,-0.013503071,0.012964346,0.04327652,-0.1102804,0.009752842,0.08952363,-0.013423447,-4.0823034e-33,0.0265241,-0.107615344,0.046113856,-0.047896273,-0.023819875,0.047469467,-0.0017194175,0.037290484,0.017201146,-0.008278529,0.1104205,0.06127628,0.033088155,-0.03437386,0.05318138,-0.008904867,0.020186933,0.04340956,0.06765069,-0.0387958,-0.030842347,-0.032783955,-0.1148536,0.072491184,0.105589956,0.08403208,-0.03549322,-0.022046996,0.0007011818,0.06723053,-0.042727813,0.051967483,-0.07313463,-0.011869443,0.0076676663,0.029992647,0.018764444,0.011801919,-0.07982156,0.0018512015,0.06468457,0.091942266,-0.029062333,0.107368864,-0.05004163,0.098938294,-0.046921305,-0.027961018,0.030106816,-0.09056419,-0.013448978,-0.086428404,0.018702818,-0.07621587,-0.018858097,0.04532156,-0.031851124,-0.009987535,-0.025705408,-0.014408279,-0.052969884,-0.05300693,-0.011317009,-0.04216442,-0.002879627,-0.018592317,-0.07290354,0.09252727,0.024679279,-0.056475624,0.03516617,0.016250255,0.070549004,0.07234486,-0.07012681,-0.056141566,0.020064112,-0.07495601,0.013638601,-0.054100037,0.062569946,-0.057427365,-0.0326865,-0.022135818,-0.041282307,0.0356208,0.08291941,0.06827354,-0.07323712,-0.0083364565,-0.024179688,0.04018203,-0.050188895,0.045583535,0.032685563,-4.2848452e-08,0.11661544,-0.05031739,0.03469826,-0.007181605,-0.051175285,0.03945717,0.01699108,0.03732526,0.01577758,-0.061925642,0.0035980886,0.08180726,0.035418,0.042975634,-0.039881725,-0.02589853,-0.088524185,0.04894663,-0.026019674,0.010851506,-0.10978276,0.00072709646,-0.02258695,-0.032774135,0.005819505,-0.010995072,0.10706991,0.033271525,-0.00015464722,-0.055237368,-0.011319597,-0.037789047,-0.00041780324,-0.024662152,0.012800418,0.029518476,0.043087456,-0.04143327,-0.03665164,-0.01699571,-0.010294957,-0.08413349,-0.09849942,-0.031892695,0.11418318,-0.024272168,0.0017036519,0.016114203,-0.05397294,-0.031281695,0.038757123,-0.006245132,0.055468794,-0.02883813,-0.076397285,-0.009046631,-0.043036155,-0.06800379,0.015351234,-0.008260137,0.034225527,0.023006776,0.13324536,0.093408816 +3.5.1.77,"This enzyme, along with EC 3.5.1.87 (N-carbamoyl-L-amino-acid hydrolase), EC 5.1.99.5 (hydantoin racemase) and hydantoinase, forms part of the reaction cascade known as the ""hydantoinase process"", which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids [2]. It has strict stereospecificity for N-carbamoyl-D-amino acids and does not act upon the corresponding L-amino acids or on the N-formyl amino acids, N-carbamoyl-sarcosine, -citrulline, -allantoin and -ureidopropanoate, which are substrates for other amidohydrolases.",384,0.99999994,-0.017234504,-0.07660749,-0.043365456,-0.07231749,0.0831367,0.025045363,-0.08950157,0.024084445,0.013543832,0.02678886,-0.04426039,-0.057039596,-0.0245536,0.023761587,0.0017993908,0.03339993,-0.10023761,-0.009319415,-0.026396006,-0.075834766,0.056783553,0.023313496,-0.013902504,-0.0010497806,0.021730306,-0.0030769247,0.0931441,0.057863303,-0.040864065,-0.064369395,-0.02258642,-0.072491586,0.011265548,-0.067740776,0.013969549,0.09153291,-0.07729051,-0.06337441,-0.023175573,0.016181488,0.014844554,-0.041172914,0.009285484,-0.030387975,-0.06339352,-0.05260333,-0.03509007,0.017226905,0.0484556,-0.047056433,-0.054053128,-0.07397998,-0.00050183246,-0.0008516551,-0.00068510784,0.04890808,-0.08559313,0.017458133,0.023724638,-0.00049747014,-0.0013387935,0.04984443,0.046135664,-0.043125276,-0.021408051,-0.0021361017,0.0054753465,-0.09009395,0.008188247,0.025935667,-0.07858993,-0.05114793,0.014449967,0.022768639,-0.0057336963,-0.03916666,-0.054852366,-0.059831508,0.019277059,-0.073283315,0.06995821,0.038432036,-0.040365007,0.023940727,-0.024221038,0.017769374,0.01841077,0.015702223,0.068015985,-0.0430656,0.009304701,-0.03841421,-0.026985656,-0.082651086,-0.058630474,-0.021056123,0.051891353,0.05757033,0.04798034,-0.03034125,0.027409721,0.016471932,-0.0499716,-0.09516455,-0.09155857,0.029455053,-0.012878889,0.09799703,-0.0029066447,-0.0043935776,-0.029994326,-0.019482197,0.016288506,0.00811839,-0.06295394,0.08549878,0.007727999,-0.046391398,-0.04868427,0.01689958,-0.0009829685,-0.026345562,0.12143334,0.051191945,0.008609708,0.050986663,-0.09251481,1.1925118e-33,0.056846324,0.011445405,0.0013323543,-0.050989196,-0.03427988,-0.049295682,-0.083485246,0.050127123,-0.017494824,-0.049453456,-0.08447077,0.039131604,0.03475926,-0.0020684667,-0.018057613,-0.009227719,0.005277891,0.038443174,-0.0349565,0.06527906,0.029437907,0.10306479,-0.08775808,0.10144503,-0.029002283,0.047001753,0.061112035,0.030472456,0.09021509,0.008813516,-0.12879248,-0.073845215,-0.032495845,-0.025104227,0.030563904,0.024065625,-0.06126396,0.013483839,0.036200024,0.007440452,0.022318318,-0.005000893,-0.0076365005,-0.061820325,0.0013900005,0.03352796,-0.017518202,0.051497918,-0.042204253,0.071818694,0.05653964,-0.05299158,0.10316384,-0.058791805,-0.057085987,0.012498378,-0.04635065,0.0050751166,0.067676164,0.048738737,-0.034754716,0.0015231713,-0.011212237,0.022268848,-0.05681955,0.0032644013,-0.03353454,-0.058889017,0.017741974,0.026808199,-0.027001763,0.008572727,0.043877255,0.06922371,0.09744692,-0.07540709,-0.028877143,-0.012880275,0.075604185,0.0034217816,-0.0081405835,0.03956692,0.038330123,-0.047498558,0.0035746999,0.0001398411,-0.038625628,-0.03916462,-0.07056122,0.05761862,0.021522425,-0.11033818,-0.0041519045,0.02849331,0.024594491,-2.9612299e-33,0.12145003,-0.10267089,0.04597281,-0.029060975,0.008110277,0.10552486,0.10420714,0.0180533,0.007443918,-0.074932784,0.10109815,-0.01637627,-0.013067121,0.00075270527,0.027485833,-0.037092652,0.013422802,0.09215302,-0.0222861,0.0024430382,-0.022475243,-0.0013434882,0.027858397,0.015783675,0.071085826,0.034506783,0.0040694126,0.09202355,0.020549452,0.092811,-0.026886677,-0.04752302,-0.0832877,-0.00248227,-0.03161415,0.0805638,-0.012780444,0.0062081954,-0.03632893,0.008807194,-0.043001812,-0.003761838,0.04343661,0.07850235,-0.05115864,0.07226354,-0.058903445,0.008685781,-0.029372785,-0.08993648,-0.00088073366,0.035742685,-0.030946804,0.0022233601,-0.051497743,0.10617034,0.06937213,0.05743783,0.0015564555,0.08762312,-0.06966447,-0.08230935,0.020030834,0.030020213,0.0089316815,0.030397711,-0.009489224,-0.0012606035,0.08292706,-0.059289183,0.14142272,-2.9221586e-05,0.07713455,0.064950466,-0.0013394894,-0.034826864,-0.0028583556,-0.051819548,0.011379512,-0.027822563,0.021047309,-0.022610987,0.0013212623,0.019405061,-0.04945305,-0.053040016,0.058603916,0.03726394,-0.045551606,0.03817093,0.048200157,0.002262255,-0.0691677,0.11071465,0.09726097,-4.689163e-08,0.07330481,-0.07780922,0.06961501,-0.04286945,0.048539408,0.056400057,0.005282812,0.037726942,0.05241589,-0.056170322,0.041463893,0.030715384,-0.04104746,0.07546207,-0.026130982,-0.0009306862,-0.024056436,0.08845853,-0.020434173,0.042986654,-0.07892892,-0.015236115,-0.1312619,-0.00033557494,-0.036061924,-0.03475195,0.04147132,0.07440868,0.017313056,-0.051318236,-0.027515925,0.03367021,-0.040426742,-0.007883848,-0.028930135,0.02857937,-0.061581846,0.016907943,-0.046730496,-0.014730198,0.019836186,0.020369956,-0.07212086,0.0041273204,0.04494675,-0.011050454,-0.061182436,0.02130578,-0.018437022,0.027706994,0.03031616,-0.011814698,0.0021906963,-0.100516886,-0.05775926,-0.0041630194,-0.014313821,-0.088120885,-0.036167737,-0.025113268,0.022897309,0.015985955,0.1938215,0.05739084 +3.5.1.78,"Spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule. The enzyme from Escherichia coli is bifunctional and also catalyses the glutathionylspermidine synthase (EC 6.3.1.8) reaction, resulting in a net hydrolysis of ATP.",384,1.0,-0.028142497,-0.03696036,-0.048446137,-0.0023804335,0.003707779,0.045592356,-0.030008543,0.021156246,0.065921664,-0.004368322,0.041642964,-0.034213938,-0.065494515,0.07457527,-0.046322,-0.06223842,-0.054773446,-0.0039219907,0.010671668,-0.08312809,0.103815064,0.09867,-0.04242581,-0.03684565,0.05519162,0.023781711,0.0406947,-0.02775362,0.003966576,-0.027205082,-0.0054665133,-0.025676219,0.04802336,-0.042810682,0.090357244,0.022225197,-0.073505886,-0.007424543,0.0862021,0.02420734,0.068360016,0.00075904443,0.009072362,-0.03927532,-0.04937605,0.0017141124,0.10950337,0.05823122,0.047798783,0.036681622,-0.011805315,-0.058866657,-0.009367638,-0.004405718,0.118088104,-0.02565797,-0.02896999,-0.11719828,-0.03464496,0.058077198,0.034948252,-0.0014214846,0.015155158,-0.083430216,0.10808905,-0.04174722,0.025254365,-0.053751606,0.022884473,-0.046211943,-0.04206215,-0.05071674,0.016354455,0.032731414,-0.027649393,-0.03715428,-0.07375619,0.005710286,0.050636504,-0.008268179,0.0050167856,-0.12515773,-0.026904548,0.02771583,0.031355657,0.008361242,0.054246727,0.042153556,0.070043296,-0.00727199,-0.07678252,-0.02799829,0.08198634,-0.016293041,-0.06345206,0.046328403,-0.020327436,0.030353539,-0.027063286,9.8146345e-05,0.020493682,0.0720335,0.04199653,-0.037482325,-0.08438257,0.06708089,-3.0057196e-05,0.1323924,-0.0056368704,-0.0060509806,-0.06456958,-0.018305216,0.04641116,0.020378048,-0.028118486,0.0030265448,0.027124954,-0.008734002,-0.024933318,0.015703514,-0.002829435,-0.03619845,0.01867004,0.0896462,-0.018763248,0.07576283,-0.03339685,3.9110394e-33,0.10924849,-0.014152118,0.06032644,0.037285898,0.034143187,0.036705542,0.0118754795,-0.033496883,-0.0007467141,-0.12852636,-0.04913689,-0.07978467,0.05032038,-0.0030889146,-0.07760882,-0.043069225,-0.070723966,0.01855844,0.08381056,0.031602006,0.0015506265,0.06252658,-0.036990527,-0.014732076,-0.01886697,0.03568127,-0.060144104,-0.014384361,0.055693064,-0.017707737,-0.023971451,-0.014968477,-0.11232877,0.005252773,0.02766184,-0.050501727,-0.028558938,-0.050046116,0.036839474,0.042610604,-0.0777473,0.006833223,-0.027759917,-0.035882413,-0.0032452373,-0.015084037,-0.041064963,0.08268828,0.024074621,0.08353631,0.038354713,-0.027168449,0.1329647,-0.101051174,-0.05483756,0.01533975,0.014253538,0.023629751,-0.0058265273,0.030897649,0.028628515,0.092326365,-0.066022135,0.0007684,-0.0056545157,0.04560916,-0.042561494,-0.043171432,0.095101625,0.09854306,-0.086274095,0.039217584,0.06267283,0.058295414,0.022114728,-0.017027842,-0.14097647,-0.011064085,-0.023730904,0.03916272,-0.0021627194,0.07048296,-0.04276612,-0.014557175,-0.08429351,0.04076374,-0.015995504,-0.11205048,0.038838852,-0.010608858,0.06619996,-0.09389803,-0.0122369,0.005953729,0.052841354,-4.135233e-33,0.067066,-0.08575262,-0.001317716,-0.02982915,-0.059556093,-0.0042989478,0.0071177147,-0.081516005,-0.050024275,-0.021481423,0.00031899934,0.0052202623,0.014405534,-0.055308953,-0.009749006,-0.055544455,-0.009333217,0.051472142,0.05100996,-0.01993154,0.028258476,0.03496271,0.04752349,-0.023958681,0.045393914,-0.020007,0.018131128,0.03781383,0.13695379,0.00794379,-0.017407952,0.032388385,-0.0133933835,-0.028714051,-0.011146856,0.062442116,-0.036402363,0.04651029,0.057768997,-0.06558379,0.009931647,0.03382567,0.012164732,0.06288283,0.010674055,0.037872046,-0.022414386,0.035473153,-0.046079393,-0.03803829,-0.029936507,0.0116763925,-0.0500096,-0.043142173,0.04739538,0.025497315,0.025901077,0.021596199,0.04435549,0.030964024,-0.080123514,-0.04115227,0.013259403,0.030298257,-0.020945057,-0.003849752,-0.13021816,0.08751521,0.07056449,0.0013443009,0.059414983,-0.028854726,0.09933767,0.010887159,0.022623762,-0.0521377,-0.04766603,-0.02760536,-0.031174472,-0.0328515,0.012601971,0.030996036,-0.10143648,-0.011943889,-0.027318548,-0.06605979,0.12011125,0.12848023,-0.02161392,0.030034736,-0.028521754,-0.048761256,-0.01532359,0.07203674,0.0022994743,-4.185143e-08,0.045798786,-0.016253244,0.06317378,-0.06505872,0.038319513,0.09020112,-0.013593151,0.009216149,0.07594603,-0.0109048085,0.025408829,0.012552425,0.018035607,0.021002019,0.029267851,0.08092792,-0.012961376,0.024929738,-0.018609274,0.018869359,-0.0644626,-0.029398212,-0.14735931,0.037949953,-0.00705562,-0.019693486,0.00036040173,0.00028126585,-0.040005933,-0.07214836,0.0017694788,-0.0126238875,0.024374403,-0.037125193,-0.03993789,0.014179384,-0.04630204,0.014758028,0.0061526787,-0.038193498,9.0960144e-05,-0.024334356,-0.062609,0.029164184,0.060420506,0.06766098,-0.03933742,-0.03552128,-0.11779258,0.040130578,-0.02108315,-0.02257117,0.011544157,-0.05532134,-0.08735722,0.011211911,-0.029779132,-0.07818587,-0.0030083375,0.0028679385,-0.0009082929,0.053347357,0.15942512,0.014652973 +3.5.1.79,"In the entry, ""phthalyl"" is used to mean ""2-carboxybenzoyl"". The enzyme from Xanthobacter agilis hydrolyses phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines. The substituent on nitrogen may be an alkyl group, but may also be complex, giving an amino acid or peptide derivative. Substitutions on the phthalyl ring include 6-F, 6-NH2, 3-OH, and a nitrogen in the aromatic ring ortho to the carboxy group attached to the amine. No cofactors are required",384,0.99999994,-0.05594085,-0.065795444,-0.10802795,-0.04987343,0.025345778,0.007876818,-0.015814228,0.038673334,-0.0029152923,-0.082145594,0.060758766,-0.08526035,-0.06904975,0.014958935,-0.0066565243,0.041100435,-0.012839029,-0.027515927,-0.0091969455,-0.006226065,0.0061868737,0.07414126,-0.006496253,-0.02595795,0.007845252,0.03434623,0.037381947,-0.01908497,0.033884842,0.0040105134,0.025819441,-0.0050616534,0.028605476,-0.022713939,0.070291124,0.06387785,-0.029193329,-0.072807014,0.027330836,0.027766073,0.058320355,0.011886395,0.07330315,-0.09976223,-0.032347582,-0.001561994,-0.012894232,0.01868611,-0.0043543056,-0.020880735,-0.017366996,-0.03628537,-0.062644824,0.063870065,-0.00853786,0.008052812,-0.07765236,-0.047293525,-0.11339859,0.03229475,0.032056876,0.090400994,0.053316917,-0.013533883,0.012880439,-0.0806341,-0.026781661,-0.10521296,0.039343208,-0.0063876817,-0.10415764,-0.045978755,0.030699488,-0.019377189,0.007711252,-0.068567276,0.03007946,-0.012556109,0.09851089,-0.076843776,-0.013010488,0.045711115,0.07458895,0.070463255,-0.015397613,-0.01106316,0.006110753,0.047253493,-0.022595566,0.011190316,0.07408978,-0.010482679,0.020148603,-0.023953008,-0.08563962,-0.014855695,0.08705695,0.041595567,0.03518264,-0.018079394,0.0020492359,-0.025142226,0.00068966,-0.08379936,-0.10630148,-0.067089036,0.02985517,0.10426912,0.012976654,-0.007792597,-0.09897604,-0.023818132,0.056107823,-0.07114313,-0.031232549,0.014898985,0.028557409,-0.01682812,-0.030279865,-0.015081783,0.010577632,-0.07241009,0.054000914,0.03917655,-0.030627964,0.037366495,-0.1152071,3.9139414e-33,0.065736525,0.03233857,0.06998948,-0.08752929,-0.018152175,0.011298451,-0.032812156,-0.011979776,0.011185208,-0.031635076,-0.009697071,-0.033427145,-0.02112336,-0.04922657,-0.015983688,0.0035099436,-0.11451547,-0.012207883,0.073558606,0.05626778,0.0695175,0.07230025,-0.065111324,0.09917226,-0.0007081173,0.04965996,-0.0011549927,-0.03433612,-0.05321402,0.013851055,-0.0048929346,-0.06261987,-0.10394625,0.05754985,-0.012788355,0.014376973,-0.046049662,-0.0726936,0.0020920725,0.0028316658,0.04673449,0.00389023,0.007745663,-0.05137102,0.05030985,0.040456615,-0.071566865,0.044902883,0.009961345,0.06103058,0.023131074,-0.033307604,0.108290255,0.049964618,-0.039059177,0.03307193,-0.029823795,0.058682915,0.013757733,-0.06157535,-0.025452426,0.0033355907,-0.011319056,-0.00068073225,-0.048217338,-0.014128577,-0.03673881,-0.024368862,0.04265794,0.05886708,-0.091276176,-0.035400525,0.0493315,0.09614105,0.05958091,-0.11006627,-0.055817597,0.025968516,0.044912968,0.027571259,0.058933817,0.045619905,0.04404765,-0.036360886,-0.05573678,-0.02607641,-0.0031051172,0.0210953,-0.0044364,0.007140111,0.04815222,-0.1269953,-0.07087242,0.004976311,0.006504026,-5.8586532e-33,0.09266272,-0.08228298,0.01390051,0.027050659,0.03859624,-0.031380147,0.017078368,-0.024629572,0.06954286,-0.030769411,0.08766336,0.021510383,0.03953631,0.03713303,0.0723594,0.018045947,-0.016541043,0.041643396,0.037542988,-0.035208337,-0.012257866,0.006303134,-0.029424936,-0.020705909,0.037066307,0.0088294055,-0.034430236,-0.014250969,0.058830135,0.03497706,-0.06512807,0.03632916,-0.025392171,-0.032208767,-0.0138473725,-0.07931785,-0.060496293,-0.01374176,-0.01214171,-0.030588428,0.013408042,-0.020504689,0.041681428,0.10035519,0.050811265,0.048038624,-0.053914357,-0.085052356,0.011206712,0.01921617,-0.020072414,0.0040778667,-0.053558327,-0.040846277,-0.04975677,0.14392185,0.01797359,0.013448059,0.04089737,0.027867101,-0.034215298,-0.07266631,0.03374534,0.016615424,-0.035297737,-0.011070974,0.03829731,0.04377348,0.1267801,-0.13615319,0.038599823,-0.0018205121,0.104822375,0.065535605,-0.06277506,-0.06250091,-0.025410112,-0.02090238,0.01706065,-0.027547589,0.035966493,-0.051733125,0.07703742,-0.0045290263,0.018587742,-0.04532993,0.07980895,0.09724512,-0.08359711,-0.024378775,0.030971833,0.014265161,0.014811215,0.09352543,0.039207045,-5.2059363e-08,-0.0012686144,-0.07025517,0.05840202,-0.05043556,0.004119045,0.058495417,-0.017412411,-0.029641429,0.04574572,-0.044884022,0.069608554,0.04641735,-0.07948267,0.0758355,-0.0061974344,0.018881075,-0.039112054,-0.03339309,-0.06427361,-0.023121843,-0.102932625,-0.0063355663,-0.058302373,0.030384216,-0.010424681,0.021524994,0.013673013,0.061624054,0.022891644,-0.056909006,-0.08188913,0.056175876,0.031912003,0.030622045,-0.100889385,0.042837672,-0.04552354,-0.08265781,0.0006480934,-0.0065554567,0.054268476,-0.05717787,-0.037332352,0.009090936,0.12094717,0.044645287,0.014370109,-0.023280416,-0.0363608,-0.0407061,0.012403292,-0.009920466,-0.056261424,-0.059417095,-0.017411828,0.07709428,0.0010414919,0.012304485,0.021229371,-0.041745786,-0.05518012,0.071003206,0.16184694,-0.01813397 +3.5.1.81,The enzyme from Alcaligenes denitrificans subsp. xylosoxydans and Alcaligenes xylosoxydans subsp. xylosoxydans has wide specificity; hydrolyses N-acyl derivative of neutral D-amino acids. Used in separating D- and L-amino acids. Requires zinc.,384,0.99999994,-0.093993135,-0.0815111,-0.09280232,-0.09899262,-0.015491497,-0.010412247,-0.024482524,-0.012617857,-0.023603082,-0.0065885573,0.09475867,-0.006825993,0.036442786,0.049837563,-0.053860936,0.056825977,-0.030017108,0.031231834,-0.07320031,-0.009237134,0.04388873,0.107732385,0.028357212,0.013517792,0.068015516,-0.052122813,0.026411697,0.0056729834,0.014845484,-0.018037377,-0.03498741,0.007668639,-0.027810426,-0.0513416,0.055123936,0.041198056,-0.0327226,0.04103867,0.058948852,0.005523853,0.040320437,-0.018444693,-0.0039264224,-0.042989723,-0.037964016,-0.0645075,-0.0333633,0.08266231,0.02133047,0.018105522,-0.03701119,-0.058254056,-0.010677122,0.03387011,0.019790296,-0.008311575,-0.043865837,-0.0320816,-0.039467774,-0.021880345,0.038051236,0.03342655,-0.006816405,0.0054937694,-0.0014981906,-0.041917708,-0.00372158,-0.03434062,0.01862996,-0.022962617,-0.07951258,-0.105387785,0.028972605,0.0476668,-0.026518406,0.01143502,0.058421362,-0.13265924,0.014035495,-0.13956693,0.07365626,0.071957245,0.027803186,0.095449574,0.05031137,0.0052896803,-0.009733399,0.00024741862,0.0054527186,-0.021502607,0.013874778,-0.033709485,-0.029020984,-0.037801806,-0.045774642,-0.020145724,0.07439114,0.11132091,0.012568141,0.028827747,0.02288962,0.029507473,0.04365753,-0.042826705,-0.083632424,0.0038343386,0.03356111,0.07102392,-0.06749426,-0.030323138,-0.062949836,-0.04957407,-0.06008556,0.00071395555,-0.014705562,0.02660787,0.13919577,-0.014525219,-0.010857159,-0.086016305,-0.042529024,-0.035471216,0.052268114,0.029846752,0.031707775,0.0988223,-0.08946861,4.151623e-33,-0.017563328,0.04497628,-0.0718367,0.010006796,-0.025750346,-0.07143918,-0.029830594,0.08711737,0.002751691,0.0135677755,-0.052417748,0.007446453,-0.0019807334,0.033149336,-4.3701537e-05,-0.055181943,0.04778209,0.0128881065,-0.019151455,0.0128237335,0.059789676,0.08025202,-0.074276455,-0.043276828,0.012563671,-0.03138446,0.039103415,-0.0048773703,0.001426129,-0.025494533,-0.011718752,-0.061153393,-0.06305556,0.11458856,0.08024456,0.09922876,-0.02927821,-0.056540716,0.04427546,-0.039222036,-0.025859771,-0.0023868158,-0.013679953,-0.037024822,0.0006791526,0.020384656,-0.106664985,0.030574162,-0.00064125936,-0.04022894,0.12506644,0.071319856,0.081391625,-0.023712324,-0.08996132,0.0081896195,-0.035355426,-0.010731141,0.050599314,0.029434746,-0.09585136,-0.060593992,-0.046963777,0.03386177,0.026201196,-0.048103917,-0.07133916,-0.059218425,-0.038550384,0.04002431,-0.10719758,-0.0249029,0.12458183,0.035486028,0.06329927,-0.04501403,-0.022418976,0.0141078215,0.044293933,-0.037638135,0.0370898,-0.0087434575,-0.013970608,-0.008810142,-0.046003398,-0.014346418,-0.0034402169,-0.0014870467,0.0070757996,-0.060147114,0.008368188,-0.054020938,-0.012845189,-0.0077500036,0.040419057,-6.2456e-33,0.013055308,0.023078367,0.012120216,-0.06140628,-0.02724108,-0.0050122403,0.05786624,0.023350375,0.042905018,-0.048892695,0.08523279,0.07198743,-0.030544234,-0.076069735,-0.008630153,0.051138528,-0.020306127,-0.026766596,0.003069669,-0.07263839,-0.042364154,0.0844659,0.031285506,-0.025904624,0.050255626,0.0063881604,-0.011256384,0.100690715,0.060905013,0.07080997,-0.05748779,0.031037139,-0.0098093385,-0.012911225,-0.07696942,0.051117234,-0.07883794,0.023781795,-0.06764713,0.017180039,0.0056790733,0.038579926,0.026380002,0.115327306,0.093587495,0.071447134,-0.06737505,-0.022229323,-0.028275194,-0.018091504,0.10222673,0.032776035,0.025022505,0.0038665046,-0.0012247453,0.14244004,0.032117996,0.05020547,-0.0006201901,-0.022598617,-0.07826371,-0.050035603,0.015965568,0.02424139,0.031965464,-0.06463875,-0.014003111,0.028232535,0.020891132,-0.045612197,0.06562619,0.052582815,-0.018863494,-0.014171327,-0.04176734,-0.04728732,-0.044398922,-0.055356715,-0.025625542,-0.022201417,0.06217378,-0.030245278,0.024458619,0.04352281,0.039277654,0.0004402326,-0.021979745,0.07010046,-0.035484184,-0.041935973,0.056514703,-0.064514674,-0.020367341,0.017904913,-0.001974276,-3.79638e-08,0.058543313,0.020211866,-0.0011610697,-0.041469082,-0.0021519745,0.017820345,-0.02515255,-0.0045165154,0.08979833,0.0048108343,-0.013754067,0.063068815,-0.069147035,0.04175102,-0.06876513,-0.010839898,-0.03621417,0.06585529,-0.07046472,-0.0022051274,-0.038206697,0.058141496,-0.13731992,0.06139444,-0.0072803,-0.006290029,0.019852862,-0.006317301,0.0012038037,0.004590003,-0.017725252,0.040947374,0.0055638473,-0.027830277,0.0012975073,0.059379123,-0.019146955,-0.06983776,0.0036194753,-0.006170009,-0.020317065,-0.053079464,0.0049638017,0.03266547,0.033445433,-0.04674713,-0.04231034,0.023480237,0.023940887,0.07549744,0.049512036,-0.013604228,-0.010632723,-0.18509696,-0.07096518,0.010583363,-0.05784931,-0.011117534,-0.027887285,-0.03320519,-0.037678346,0.037784476,0.2199595,-0.017642807 +3.5.1.82,The enzyme from Alcaligenes xylosoxydans subsp. xylosoxydans and Pseudomonas sp. is specific for N-acyl-D-glutamate. Requires zinc.,384,1.0,-0.111236356,-0.04681581,-0.090296224,-0.04694188,-0.02178937,0.0029535666,-0.046635047,0.0038020117,-0.03185181,-0.032613073,0.08586113,-0.027799897,0.020590091,0.07694727,-0.054716155,0.03651905,-0.016915115,0.018988833,-0.054329205,0.0242229,0.049144726,0.13688278,0.049847513,-0.058851674,0.04533447,-0.017095221,0.039196476,-0.0054656556,0.07137351,0.010053663,-0.06291697,0.024242928,0.061058264,-0.020123571,0.07541481,-0.0048915655,-0.023824219,0.039668024,0.072320916,-0.020110734,0.053580534,0.049003035,0.018077003,-0.05079796,-0.034307934,-0.010836289,0.03405304,0.03146096,0.02974295,-0.004411493,-0.04215194,-0.05319083,0.0064506703,0.042267043,0.024469865,0.036304258,-0.06530958,-0.06953589,-0.058956012,-0.0012036723,-0.00012158352,-0.02202336,-0.013963002,-0.005240027,0.009261871,-0.02894561,0.0009857235,-0.028668614,0.010348551,-0.07470358,-0.05194295,-0.07080709,0.03982277,0.04474576,-0.05210176,0.024994608,0.088071465,-0.15460284,-0.016576009,-0.093598515,0.06500976,0.022447243,0.06320505,0.089823425,0.06946029,-0.030694846,-0.027936658,0.10217552,0.019323314,0.04818299,0.026860557,-0.011065873,-0.046760313,-0.054768514,-0.07972075,0.036289416,0.050476696,0.050177358,0.0022845385,-0.012291222,0.047385868,0.036729846,0.104239576,-0.06092408,-0.04510719,0.032655492,0.05082748,0.09025571,-0.06762481,-0.028953686,-0.011207807,-0.016793054,-0.04436053,-0.040340926,-0.04534454,-0.0009924299,0.06674747,-0.013438919,-0.10493604,-0.03714955,-0.051006697,-0.050627157,-0.016807063,-0.00065795804,0.009759298,0.07658786,-0.09896007,2.343475e-33,-0.021606637,0.07791302,-0.07203015,-0.042750373,0.016258797,-0.034124985,-0.0048046852,0.037021454,0.026214067,-0.03563286,-0.028712077,-0.040497836,-0.0027611463,-0.017060453,-0.032812152,-0.022088643,-0.016755259,-0.025615769,0.022858975,-0.0019926587,0.096443094,-0.00079916633,-0.08728964,-0.042344462,0.030241312,-0.0022554523,0.055171244,0.008880791,-0.03374336,-0.041532252,0.018102987,-0.061494987,-0.062734395,0.048268627,0.12790023,0.05600895,-0.011801982,-0.040444076,0.01580519,-0.03861509,-0.036991328,0.03431442,-0.037565004,0.02589347,0.032773726,-0.026172318,-0.14684145,0.09298983,0.014220712,0.06967184,0.08496683,-0.0013788766,0.03191988,0.026915964,-0.06962094,0.02827216,-0.053082827,0.00090685894,0.055204745,0.00095319794,-0.028899472,-0.029420584,-0.11120454,0.04935891,0.015787818,-0.008486951,-0.070014894,-0.09799711,-0.05832498,0.061300684,-0.06030912,-0.10195959,0.086234495,0.06325387,0.050695814,-0.06971612,-0.0213051,0.02029089,0.059725612,-0.022337474,0.0011780678,-0.02539774,0.015520235,-0.007108619,-0.11362983,-0.01830266,0.012027365,0.014093055,-0.013538922,-0.070516415,0.056435946,-0.064202905,-0.011380092,0.03933292,0.005435865,-3.5710416e-33,0.044892084,0.019009357,0.083734676,-0.05564093,-0.009539824,0.021472838,0.020977877,-0.025616122,7.889718e-05,-0.06321393,0.08426298,0.088746615,0.032138612,-0.0035544517,0.041993644,0.07400621,-0.0032036884,0.033340484,0.04102798,-0.031438585,-0.012305275,0.10240594,0.01578099,0.048152525,0.046356168,0.009067371,0.0013049752,0.04738059,0.048801795,0.11092277,-0.043580785,0.059647046,-0.006556368,-0.02908734,-0.017316228,0.018791929,-0.00928795,0.034453444,-0.09120201,0.029863583,0.046438318,0.051682122,0.014746148,0.105882496,0.01146417,0.08289003,-0.052670144,-0.024008442,-0.020357324,-0.047011565,0.044530734,0.097908296,0.0025086005,-0.03479365,0.038919766,0.09876744,0.03928861,-0.013674644,-0.013533099,-0.07058035,-0.07944679,-0.10624776,0.0042430884,-0.010165338,0.053728033,-0.043154623,0.066884525,0.055390686,0.013835986,-0.03218257,0.03037616,0.06629386,-0.025157042,-0.036623333,-0.10699226,0.00953467,-0.023503339,-0.040272105,0.0047704694,-0.007043568,0.11000974,0.016101254,0.018282281,0.05981008,-0.0052575516,-0.010331242,0.017642515,0.09101221,-0.041085664,-0.007366464,-0.013496749,-0.054963842,-0.00091563497,0.022712894,0.02542504,-3.0240333e-08,0.019237561,-0.027408639,0.008752785,-0.050881714,0.018931268,0.03515495,-0.06785731,-0.03135944,0.09697408,0.030842623,0.013003374,0.07418501,-0.05779173,0.064769045,-0.04516395,-0.026162526,-0.06764046,0.020615714,-0.057732496,0.002370095,-0.05514754,0.037444703,-0.121604696,0.035314325,-0.0012685236,-0.03707178,0.018069083,0.010488919,0.0014700566,-0.0034683468,-0.06346151,0.0092956945,0.014846889,-0.027036434,-0.043471362,0.001006773,0.019458285,-0.10549727,-0.023501562,-0.029463481,-0.009546225,-0.03731109,0.005118395,0.032005694,0.024039852,-0.04602197,-0.016152008,-0.006884916,0.007749717,0.0045504025,0.07824636,-0.05028095,-0.002563361,-0.16846684,-0.09016806,0.025197038,-0.051489312,-0.0028580937,-0.0456531,-0.032961257,-0.012580567,0.051930074,0.13357563,-0.015934162 +3.5.1.83,The enzyme from Alcaligenes xylosoxydans subsp. xylosoxydans is specific for N-acyl-D-aspartate. Requires zinc.,384,1.0,-0.11290919,-0.026755564,-0.113885105,-0.013078995,0.004255669,0.011124644,-0.066805616,-0.02389494,-0.037433583,-0.052515548,0.060861282,-0.0092531005,0.0105094565,0.0306733,-0.073815994,0.052968904,0.018760674,0.005265369,-0.039176393,-0.0007934642,0.02607244,0.06048717,0.11575096,-0.02341383,0.061876066,-0.07488461,0.010306717,-0.0018802909,0.053435873,-0.033027325,-0.027133137,0.038894814,0.032337643,-0.007901483,0.060101338,-0.000460941,0.009026759,0.050929595,0.004708538,-0.0057608024,0.067889705,0.00255678,0.007902964,-0.006404777,-0.037679996,-0.013166728,0.010064152,0.064577326,0.02524323,0.034113232,-0.06571566,-0.0438168,-0.017290892,0.023087597,-0.00733128,0.034049667,-0.10053965,-0.07098401,-0.061322562,-0.026126638,0.026393762,-0.018242916,-0.010301583,0.007535357,0.014661886,-0.039467428,-0.043114394,-0.030559111,-0.022215428,-0.037524097,-0.03244861,-0.08291641,0.014274379,0.057490192,-0.03157917,0.037492935,0.062130414,-0.15846816,0.0030466549,-0.07387038,0.039221685,0.039597265,0.048779745,0.09339463,0.05807583,-0.01313168,-0.03703382,0.0861902,0.017770628,0.061874766,-0.003539444,-0.0076306383,-0.013490454,-0.021212494,-0.07541475,0.029735176,0.09940818,0.08048379,0.012314501,-0.0023941346,0.01890687,0.033834238,0.07101979,-0.028952321,-0.057902753,0.020607973,0.019172648,0.061613943,-0.05905689,-0.023824086,-0.028361753,-0.061304405,-0.029620308,-0.029427018,-0.03416888,0.014858789,0.037859708,-0.007548754,-0.063986495,-0.057368554,-0.048746705,-0.010755579,-0.033970818,0.034028333,0.024298849,0.11138088,-0.104177035,1.7108266e-33,-0.01430545,0.10326077,-0.054216906,-0.010014723,-0.02686708,-0.021092756,0.005438304,0.04630517,-0.023017256,-0.028539844,-0.01891191,-0.07518197,0.029159097,-0.013794926,-0.029897025,-0.079173654,0.024385778,-0.0024870762,0.00065368135,0.00563903,0.085595876,0.021646002,-0.105849415,-0.01882322,-0.0051198355,-0.020759901,0.024985785,0.035226725,-0.032614194,-0.04056869,0.015225773,-0.05269443,-0.04308638,0.061157536,0.11853024,0.05793254,-0.025210358,-0.047421522,-0.011407226,-0.07043884,-0.061587192,0.026039919,-0.024255782,0.0032055061,-0.008267351,-0.036628917,-0.12736987,0.045883268,0.044227522,0.02649218,0.09314075,0.056615893,0.08140443,0.0037513429,-0.054452203,0.036991175,-0.072259806,0.02692517,0.028498627,-0.011166984,-0.061737332,-0.056437653,-0.080571525,0.034209926,0.00050909206,0.012776115,-0.0563145,-0.07299598,-0.09421985,0.06492979,-0.064446524,-0.07046843,0.10404304,0.05173868,0.08871086,-0.020712836,-0.01719183,0.021612013,0.047376238,-0.066020474,-0.011821564,-0.027436487,-0.0012093631,0.009012581,-0.08788868,-0.028887643,0.012226601,0.013452837,0.028090106,-0.047799014,0.053012416,-0.09154124,-0.0051021087,0.027537672,0.03293212,-3.5476133e-33,0.018923579,0.004185427,0.08970926,-0.07299475,-0.019284675,0.010477122,0.070978396,-0.032552693,0.0025304423,-0.06161044,0.103291534,0.07243922,-0.01296136,-0.020117162,0.0018715346,0.09238836,0.00045782293,0.05770344,0.07879508,-0.024133846,-0.060810745,0.12419454,0.024007853,0.01998898,0.022359079,0.013586625,0.03582015,0.01856227,0.059484888,0.1004233,-0.031886566,0.038021524,0.006587121,-0.014107305,-0.06219497,0.06344445,-0.04074718,0.013022478,-0.10943934,0.021869581,0.013998589,0.022716355,0.011557359,0.12648255,0.059660718,0.06315947,-0.06645423,0.022184389,-0.02162291,-0.024332589,0.029773183,0.08997462,0.022067444,0.015304692,0.028599462,0.134302,0.06464449,0.015690368,-0.0002041683,-0.08183817,-0.06914774,-0.06076119,0.030330393,-0.0041452614,0.056261573,-0.07569828,-0.0066517494,0.052744392,0.016097672,-0.02596518,0.020306295,0.094930194,-0.03135877,-0.020148778,-0.028906884,-0.048809025,-0.011683987,-0.03433269,-0.038422454,0.01796639,0.014176722,0.017959535,0.031901743,0.07619443,-0.0056293593,0.014178622,0.017379992,0.07100095,-0.059953205,0.00703965,0.0025229347,-0.077134155,-0.031238811,0.04209982,0.029354036,-2.6693016e-08,0.035036962,-0.020496417,0.014303078,-0.11048455,0.015678464,0.017927114,-0.067918055,-0.04762067,0.08255481,0.03464208,0.001039463,0.08139945,0.005580075,0.027340524,-0.030755945,-0.05688322,-0.01047637,0.04203744,-0.058266755,0.0053671263,-0.04804041,0.05836691,-0.1044266,0.044797737,0.00011472431,-0.032222655,0.010572263,0.0061453506,0.0042427634,-0.00729085,-0.024967501,0.019204192,0.044691607,-0.04308618,-0.012520028,0.014279561,0.00094919326,-0.11529042,0.03282415,0.00021210755,-0.032311343,-0.014735987,0.034770552,0.048710074,0.02553036,-0.03246121,-0.018508587,-0.016677072,-0.010962601,0.046786852,0.035073925,-0.04818263,-0.048133627,-0.20253658,-0.041933548,0.014178571,-0.057774205,-0.017371867,-0.021871634,-0.05010995,-0.0061905133,0.03193013,0.17592543,-0.064419985 +3.5.1.84,"The enzyme, characterized from the bacterium Rhizobium leguminosarum bv. viciae 3841, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazide herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The substrate, biuret, forms by the spontaneous decarboxylation of 1-carboxybiuret in the absence of EC 3.5.1.131, 1-carboxybiuret hydrolase.",384,1.0,0.011374527,0.0052790614,-0.11086863,-0.06582555,0.09359897,0.07540926,0.009283315,0.09537173,0.024194416,-0.040101387,-0.0016304032,0.013523575,0.0018552714,0.018763179,-0.085451774,0.039591268,-0.031624697,0.04912154,0.012420116,-0.0038218074,0.046755385,0.11912825,-0.074091166,0.041228253,0.053875547,-0.0023787334,-0.018860055,-0.05192112,-0.07362887,-0.10299507,0.048287995,0.050507057,0.03760412,-0.030429328,0.07964066,0.054688286,-0.06750521,-0.027039096,0.07095139,0.038786046,-0.011140224,0.040752612,-0.030832358,-0.026405105,-0.0068803933,0.024331294,-0.0039298465,0.009957741,0.015707204,-0.018507257,0.0004919301,0.030503454,-0.00084632274,0.012751938,-0.032298855,-0.08455038,0.003055014,0.05683259,-0.14668737,-0.019043894,0.042973015,0.03469438,0.007694251,-0.01388486,-0.027987778,-0.033886712,-0.03472132,-0.04376334,0.07403873,-0.02765999,-0.057175186,-0.11761282,-0.041482884,-0.012099871,-0.0237164,-0.034795776,0.032549523,-0.026873797,-0.008346706,-0.033500604,-0.027631951,-0.045966085,0.06066272,0.007056677,0.03353181,-0.038386438,-0.06300235,0.04799931,0.12479874,0.045463927,0.07949114,0.06892381,0.05235146,0.009054307,-0.02284984,0.029125476,0.018627338,-0.07522168,-0.025682589,-0.025508989,0.0389767,0.01575458,-0.043999154,-0.07626595,-0.021176942,0.060988516,0.017936602,0.05400512,0.030406263,-0.025801882,-0.055263806,-0.02798003,0.045970555,-0.036772523,-0.052740276,0.080298066,0.0028683408,-0.0035979196,-0.041724015,-0.067477524,0.045360792,-0.026259804,-0.011224496,-0.0127201835,0.0054549226,0.06324422,-0.11318599,2.6625728e-33,0.04531905,-0.006186165,-0.09930362,0.02297368,-0.0732092,0.049350504,-0.01016522,0.035880737,-0.03269877,-0.096978016,-0.045752764,-0.11103046,-0.0012892457,-0.059450664,-0.109394185,0.03423184,-0.07044133,0.0038583395,0.049073935,0.008217782,-0.0503825,0.06579915,-0.14945404,0.005984979,0.0045681847,0.02430818,0.03154816,-0.009194288,-0.040666033,0.008852685,0.022193283,0.023132572,-0.13209532,-0.004260304,0.07201163,-0.014158314,-0.023026528,0.02772004,-0.0082912,0.06943527,0.0129455,0.016393716,0.03890397,-0.05716134,0.110701546,-0.02718715,-0.04795581,0.17517278,-0.019058231,0.03676947,-0.003147138,-0.024344465,0.041844267,0.07662603,-0.07210484,0.086322546,-0.03696938,0.012674228,0.058190078,0.028707534,0.029345067,0.049463432,-0.06118196,-0.0077540665,-0.007842396,-0.035000943,-0.046853773,-0.025715135,0.023900894,0.069895424,-0.04927645,-0.04309598,0.040794004,0.022036957,0.0698945,-0.10952389,-0.018243343,0.018923786,0.07928165,0.045241635,-0.00043865337,0.019059934,0.037110552,-0.06135302,-0.0379466,-0.02091447,-0.001684438,-0.017394362,-0.050192058,0.03747109,0.09572382,-0.06620504,-0.016965931,0.043264244,0.007908866,-2.2598967e-33,0.10515614,-0.03332036,0.011255493,0.057427738,0.019129576,-0.0021863056,0.031910323,-0.029360313,-0.0406439,-0.0027557185,0.08581899,-0.009936998,-0.036718916,-0.0032699334,0.053799532,0.021620063,0.09116988,0.022951845,-0.043296356,-0.017153157,-0.053247906,0.06334936,-0.01536653,-0.005956858,-0.07007421,-0.0024577973,-0.008611729,0.03269051,0.062228773,0.043028686,0.039911583,0.02124696,-0.06291189,-0.035278216,-0.018414617,0.0904471,-0.04085289,-0.0024005608,-0.058482148,0.026592482,-0.011346478,-0.02251285,-0.04763906,0.019435907,0.08669377,0.03276139,-0.07151501,0.014522272,0.014404922,-0.0618963,0.058902185,-0.027577205,0.026299473,0.0047409805,0.0084459055,0.03939423,0.019676153,0.040148944,-0.025195815,0.07690789,0.017764807,0.027531136,-0.0011695563,0.0025506327,-8.1160455e-05,0.028767092,0.0068187164,0.10531132,0.07897978,-0.007377965,0.010817051,0.080143236,0.08074968,0.03592503,-0.08890665,-0.026055692,-0.04261496,-0.04659817,0.010676268,-0.0617543,0.033035807,0.0069063227,0.0546946,-0.04902319,-0.008003081,-0.11329656,-0.04317055,0.08230516,0.0017352729,0.00050847017,-0.03253494,-0.056595795,0.0041260733,0.08829337,0.096684776,-4.5328584e-08,0.021453789,-0.06910113,-0.018081976,-0.051556088,0.020579014,0.033601727,0.018253203,0.06798523,0.05141872,-0.08499733,-0.05257357,0.0047625233,-0.0420815,0.066962115,0.07476954,0.038465317,-0.060364213,0.042168453,-0.028814653,0.067554496,-0.014369049,-0.028950647,-0.16969785,-0.020102246,0.00089987786,-0.012273591,0.003001907,0.03666791,0.09420543,-0.005991878,0.043397248,0.013128491,0.034927037,0.011693763,-0.03862473,-0.042967975,-0.042402156,-0.0531285,0.035690945,0.01936981,-0.010841765,0.00015947987,-0.078740194,-0.014163695,0.03279496,-0.08484828,0.004960435,-0.013719669,-0.041473277,-0.05607573,0.07061552,0.015796283,-0.001227456,-0.0034563814,0.040288508,-0.02372752,0.02615376,-0.07095372,0.007948205,-0.0545212,-0.06559234,0.021198308,0.14543615,-0.016702976 +3.5.1.130,"The enzyme participates in an L-lysine biosynthetic pathway in certain species of archaea and bacteria. In some organisms the enzyme also catalyses the activity of EC 3.5.1.132, [amino group carrier protein]-ornithine hydrolase.",384,0.99999994,-0.056434363,-0.066810966,-0.024377517,-0.03913982,0.12729836,0.050726153,-0.07504647,-0.022320418,0.036794774,0.005204549,-0.021840107,-0.056443542,-0.028993249,0.04642171,-0.02602188,0.08288909,-0.15326746,-0.03852674,-0.0075792167,-0.04380172,0.11433505,0.067556076,-0.012022618,0.038974985,0.00557497,-0.039806202,0.050607245,-0.04627598,-0.024363607,-0.046967328,0.001890049,-0.12261696,0.0390417,-0.039986387,0.024411157,0.098772444,-0.06366647,-0.08906398,0.044093017,0.048784386,0.029602395,-0.04346097,-0.06308286,-0.045207705,-0.034369383,-0.03084089,-0.003372729,-0.044533923,0.01078997,0.0067685847,-0.0049055573,-0.025383474,-0.038360976,0.009985776,-0.045594573,0.006283797,-0.045764454,-0.014574848,-0.022510715,-0.01708814,0.05824589,0.0394975,0.027496548,0.02981237,0.023688382,-0.06557782,0.009395663,-0.06474518,0.024113584,-0.089895755,-0.026183039,-0.11093705,0.0064327577,0.0762176,0.06090197,-0.022718538,0.015766589,0.037447676,0.019879349,-0.042936787,0.026013631,-0.05623644,-0.063281074,0.11865956,0.012490005,-0.07173002,-0.011220839,0.051329218,0.049033783,-0.02185431,0.053961873,-0.08492315,-0.025880836,-0.014673383,-0.016569925,0.01020669,0.023836302,-0.017059185,0.015910998,-0.039545894,-0.03608126,0.06836335,-0.071087435,-0.06377057,-0.07132765,0.016255045,0.026656684,0.11825259,0.018483233,-0.029512975,0.022692828,-0.034139156,0.08187671,0.06807505,-0.037071984,0.07407708,0.019512305,-0.06966432,-0.020355212,-0.015909286,0.024810432,-0.033752915,0.054482903,0.1091241,-0.073754445,0.11634717,-0.1293179,7.605609e-34,0.08277169,-0.0011595779,-0.014476554,-0.04824918,0.004167809,0.02880291,-0.06526507,0.027953094,0.009642506,-0.054312367,-0.041118845,-0.054188147,0.07998003,0.013637097,-0.044277724,-0.016814975,-0.028991777,-0.013840193,-0.016597332,0.06781384,-0.03461114,0.0088634575,-0.057187084,0.069147535,0.056872454,0.036950897,0.049361024,-0.04288301,0.01764957,1.49875395e-05,-0.010843803,-0.1370453,-0.096419185,-0.025084283,0.07276067,0.012897683,0.024553865,-0.01882355,0.0013440861,0.014680995,-0.007868143,0.03522449,-0.004273752,-0.054996546,0.030579492,0.0326359,-0.034479342,0.15602593,-0.003092724,0.035867795,0.0639273,-0.0563154,0.06370702,-0.040027857,-0.049029145,0.030176155,-0.05015036,-0.015523253,0.032069393,0.011814328,0.06558905,0.057802506,0.033360332,0.046567455,0.016030254,0.009655446,-0.020889716,-0.026144901,0.001872373,0.06468564,-0.12164377,0.016347012,0.08528989,0.006052429,-0.010791849,-0.04910863,-0.11037065,-0.011611139,0.0040403125,0.02492501,0.021417717,-0.096028216,0.040769912,0.016535962,0.0022787824,-0.012865972,-0.0014882863,-0.051979374,-0.0011090966,0.00907743,0.043674517,-0.06033132,0.00012362421,0.049827203,-0.046275783,-2.2548334e-33,0.08270284,-0.15154259,0.029993549,-0.07944886,-0.031721886,0.03395197,0.0125882765,0.0042589284,0.032210093,0.011650125,0.061682034,0.022433016,0.037095115,-0.08076413,0.07750373,-0.01639786,-0.018030306,0.04754758,0.03533832,0.05148602,0.039756663,0.004811407,-0.004806117,0.02753603,0.08780064,0.0271881,-0.04270489,0.11951968,0.02218458,-0.006786583,0.0055895443,0.0033943572,-0.012388445,-0.06632908,-0.0035884585,0.05986084,0.012671993,-0.038629305,0.06462013,-0.008884367,0.026120594,0.023725413,0.015455442,0.039088715,0.0067534707,0.05471194,-0.053281054,-0.0124522075,0.004035439,-0.06626493,-0.00832679,-0.043954328,0.05376246,-0.001992334,0.0025974752,0.07689627,-0.03653141,0.052093223,-0.009550328,-0.0037741624,-0.011670344,-0.04019696,0.035271168,0.05474353,-0.04711473,0.0307251,-0.08017494,0.057825163,0.0042172773,-0.02002433,0.030335374,-0.06381119,0.044711847,0.0978796,-0.037985064,0.003302522,-0.0760805,-0.10095024,0.027541174,-0.01409984,-0.03952033,0.024912428,-0.0031661708,-0.07275777,-0.017848423,-0.076909095,0.03696058,0.15489727,-0.014615553,0.0036892968,-0.009739533,-0.057274006,-0.055426273,0.012897899,0.08958996,-3.3127257e-08,0.043165714,-0.036670282,0.05799593,0.0048246477,-0.012640157,0.0079876445,0.030052645,0.021021284,0.019471427,-0.049265437,0.027892489,0.029652426,-0.020574622,-0.0011512422,0.043824762,0.03325155,0.0052543217,0.07140682,-0.047033027,0.010177494,-0.007043253,-0.024291445,-0.071246654,0.009863281,0.010089282,-0.044284068,-0.0042213174,0.052581627,0.0084786005,-0.07088598,-0.030775057,0.009521576,0.032979354,-0.010055901,-0.07210491,0.04546593,-0.062389918,-0.0482656,0.035688143,0.008327617,-0.017152209,0.0036185542,-0.05958143,-0.015432011,0.040709063,0.020840388,-0.0076221423,0.015719967,-0.0147928195,0.025725976,0.04459326,-0.068470806,0.03335648,-0.04717927,-0.0474078,-0.023144774,-0.06945193,-0.045239426,0.0010849409,-0.04580558,0.017175209,0.07163214,0.22770831,-0.07459365 +3.5.1.85,Inhibited by phenylmethanesulfonyl fluoride. Some related acetylated compounds are hydrolysed with variable enantiomeric selectivities.,384,0.99999994,0.07224883,-0.0617967,-0.079149164,0.00058422936,0.089675486,0.078537464,0.015933571,-0.0042189495,0.007136536,0.012654728,0.062965654,-0.024743956,-0.046593163,0.023548793,-0.060826804,-0.01613203,-0.013754377,0.095532775,-0.082657695,-0.045304112,0.01593701,-0.024714652,0.030923925,0.04606403,0.017543985,-0.010411868,-0.017466797,0.028742725,0.008228022,-0.04645106,0.056848764,0.0705584,0.018613175,-0.037797924,0.019887652,-0.00020101012,-0.084041186,-0.0001247794,0.09971723,0.006088967,-0.08275263,-0.04934886,0.019840501,-0.06106453,0.014023719,-0.064857714,-0.037439015,0.027069664,-0.0080506215,0.038418405,-0.019107876,0.08600873,-0.0429691,0.042874098,-0.016561648,0.004876903,-0.014213765,-0.0040796925,-0.06399504,0.084702455,0.0077370205,-0.031913333,-0.015320006,0.010659944,-0.09314833,0.03764949,-0.04291031,-0.046219986,0.063262,0.063920364,-0.020574706,-0.020151451,0.056153305,-0.049319636,0.08280175,0.0910124,-0.02526522,-0.015090017,0.04798366,-0.0459222,0.13940395,-0.0016835424,0.16914207,0.079290725,0.09654837,0.013599365,0.047950365,-0.017016424,0.049296387,0.043146513,0.024696963,0.019513952,0.04902107,-0.02621025,-0.048382357,-0.012401329,-0.01773264,-0.041512974,-0.028268134,0.094564274,0.02835295,-0.04192793,0.024725104,0.00095714343,-0.019262364,-0.0063215327,0.02235103,0.021842077,-0.03143443,-0.018836398,-0.07236346,0.03072187,0.007698977,-0.03857216,-0.05517346,0.0098555265,0.012161887,-0.086548924,-0.003035337,-0.03463181,0.04950172,-0.062849544,0.04924203,0.021661201,-0.037919633,0.046115022,-0.007552063,5.879502e-33,0.03343033,0.05041362,0.07396575,-0.010477174,-0.06483285,-0.06063111,-0.041481238,-0.04364373,-0.0050043846,-0.0074943104,0.009051147,0.028021326,-0.0036456822,0.024547612,0.013992984,-0.018888885,-0.04316423,0.014641051,0.059317797,-0.05812972,0.07486575,0.037637938,-0.07512949,0.012312936,-0.049521726,-0.033007856,-0.077995576,0.056509905,0.041918006,0.0057009924,0.0380407,-0.0123118665,-0.077860445,0.020228464,-0.05915484,-0.053097222,-0.06717819,-0.0710032,0.030431116,0.029256739,0.06451557,0.07042884,0.020468807,-0.00015583723,0.0088234665,0.013190328,-0.036481854,0.07190436,0.032685332,0.04256688,-0.0005324861,0.042716004,-0.0018415082,0.0074591176,0.0010265618,-0.030567618,-0.011927711,-0.056455,-0.014138709,0.022370316,-0.06229309,-0.050234858,0.045525473,-0.057314016,-0.006432611,-0.024743421,0.031650748,-0.0821016,-0.034704756,-0.05902761,-0.05290167,-0.0018595763,0.09743432,0.026934499,0.018095376,-0.057124566,0.03338253,0.0065321196,-0.016953792,0.039536,0.04446824,-0.07385318,-0.013648571,0.0758579,-0.050287805,-0.032278016,-0.13996291,-0.04751819,0.08644695,0.0087041715,0.008516644,-0.010929808,-0.035166077,0.06616607,0.021069134,-5.5066962e-33,0.054466967,-0.042694014,-0.028730068,0.018091494,-0.06394393,0.096050635,0.0150381,-0.022866035,0.050291058,-0.014264434,0.09620144,-0.02140264,0.059159696,-0.10264305,-0.065775566,-0.03844644,0.07051146,0.035662994,0.0145097645,0.07113579,-0.030485991,-0.009177813,0.03857745,0.043922298,0.037457734,0.10203255,-2.2214515e-05,-0.06230607,-0.016077466,0.07937827,0.025652312,0.02518214,-0.034576915,-0.01234823,-0.04671208,-0.012675307,-0.051817182,0.0025907147,-0.13135175,0.051321752,-0.040404864,0.042371053,0.075448655,-0.014314499,0.040273655,0.029625556,-0.016940616,-0.019821143,0.04349189,-0.030946776,-0.023397911,0.061465614,-0.10747077,-0.01725889,-0.015501029,0.031687148,-0.02736818,-0.10597669,-0.024522537,0.020248368,-0.004530895,0.0059652724,0.0021500282,-0.12108429,0.02286191,0.014650552,-0.055127665,0.12679017,0.1219276,-0.046607375,0.061622117,-0.014706843,0.118790515,0.10528151,0.054522388,0.010681763,0.049842346,-0.09749877,-0.043717545,-0.028219027,0.029993096,0.034196004,-0.07037098,-0.058378395,-0.11259173,-0.06674979,0.0053351424,-0.06713512,-0.031389765,-0.033987325,0.039615456,0.019258952,-0.02783209,0.036864687,0.040007148,-2.7763734e-08,0.028678445,-0.041133497,-0.03826098,-0.04386959,-0.0842579,0.016722955,0.08045865,-0.010736369,-0.0164107,-0.10147115,-0.0366273,0.0958166,0.079946674,0.029181782,-0.063841335,-0.026190862,0.0016679567,0.08394742,-0.080149576,-0.046669934,-0.053267065,-0.019952036,-0.01341712,-0.0708576,-0.027722726,-0.035716426,0.055497155,-0.049678117,0.05511609,0.044350713,-0.05148501,0.0011180494,-0.027436025,0.03553875,0.038265266,0.09688781,-0.029732026,-0.031285185,-0.08042495,0.027098883,-0.036006786,-0.004506739,-0.06428981,0.023157159,0.057787765,0.01752002,0.023269286,0.06567495,0.06580306,-0.007737988,0.023408337,0.01483472,-0.046893604,-0.012722734,-0.07093334,0.031420358,0.006184748,0.010692607,0.028949346,-0.09955859,-0.07681862,-0.09405242,0.06425532,-0.014672671 +3.5.1.87,"This enzyme, along with EC 3.5.1.77 (N-carbamoyl-D-amino-acid hydrolase), EC 5.1.99.5 (hydantoin racemase) and hydantoinase, forms part of the reaction cascade known as the ""hydantoinase process"", which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids [3]. The enzyme from Alcaligenes xylosoxidans has broad specificity for carbamoyl-L-amino acids, although it is inactive on the carbamoyl derivatives of glutamate, aspartate, arginine, tyrosine or tryptophan. The enzyme from Sinorhizobium meliloti requires a divalent cation for activity and can hydrolyse N-carbamoyl-L-tryptophan as well as N-carbamoyl L-amino acids with aliphatic substituents [2]. The enzyme is inactive on derivatives of D-amino acids. In addition to N-carbamoyl L-amino acids, the enzyme can also hydrolyse formyl and acetyl derivatives to varying degrees [1,2]. ",384,1.0,-0.028116954,-0.11343628,-0.081294514,-0.060118575,0.062579446,0.03610591,-0.06353159,0.024366453,0.0070982412,0.021805804,0.004104722,-0.04848395,-0.045928553,0.078804165,0.03263224,0.07504497,-0.06765705,-0.0067884875,-0.050237346,-0.03653219,0.058009777,0.03891166,-0.0017193268,-0.014020213,0.008682835,-0.03619653,0.07819581,-0.009712284,-0.01324173,-0.04224922,0.012233556,-0.07304488,0.023803174,-0.059684776,0.0409144,0.03500846,-0.10613052,-0.08706484,0.031730928,-0.0058531524,0.034855552,0.0038075887,-0.020311784,-0.07386525,-0.056041166,-0.06273056,0.014509363,0.014137753,0.04785105,-0.02198411,-0.058913946,-0.09532747,-0.019205779,-0.013242335,-0.04495775,0.007770666,-0.080413595,0.0009913961,0.01348757,0.0052722977,0.0049734474,0.07726371,0.058872562,-0.030917019,-0.023247352,-0.03704578,-0.011886195,-0.09537666,0.050683364,0.009636048,-0.067843914,-0.062193606,0.03663731,0.054235797,-0.019806478,-0.011934541,0.026789216,-0.036408745,0.014760944,-0.10201572,0.04785326,0.031016823,0.0022175335,0.0733482,0.00014927208,0.017544033,-0.02719415,0.079986975,0.09073796,-0.023803227,0.062308,0.019829528,-0.034206845,-0.0710399,-0.035593666,-0.013419178,0.08097277,0.027418364,0.017263358,-0.019643974,0.050605424,0.02776271,-0.04053419,-0.09114835,-0.0728609,0.04450723,0.025385737,0.08149981,-0.01647105,-0.04237734,-0.04772001,-0.006866932,0.035121962,-0.03232946,-0.07276697,0.02858337,0.041957177,-0.022776848,-0.058926735,0.029635776,0.014852331,-0.055500817,0.107533164,0.01542948,0.032963187,0.057918012,-0.11876936,3.7488994e-33,0.05804106,0.016485196,-0.024571052,-0.04566041,-0.016051596,-0.041129608,-0.050291006,0.021283481,-0.027641937,-0.020920284,-0.09138505,-0.014783294,0.02015498,-0.017017212,-0.009839041,0.014154988,-0.03885325,-0.008226837,-0.012874415,0.07818095,0.047086135,0.022093732,-0.09205116,0.07631525,-0.023887789,0.06882333,0.08272792,0.028748624,0.018605204,0.007291291,-0.13080005,-0.08423705,-0.08096052,0.044901446,0.033451058,0.0053367084,-0.07047754,-0.005619617,0.021467501,-0.00014835564,0.0015306164,0.0075404844,-0.030084385,-0.021014448,0.023724964,0.047057863,-0.0001943961,0.046082884,0.0035381871,0.07024692,0.08011964,-0.09787732,0.09244818,-0.041120164,-0.059225082,0.017941408,-0.042589225,0.022757694,0.06342357,0.029537084,-0.02403466,-0.008880583,-0.02395095,0.036320444,-0.02433834,-0.01034874,-0.039929524,-0.08577246,0.01677091,-0.0030451315,-0.029167231,-0.045182865,0.092523925,0.04755317,0.07227979,-0.08198446,-0.011188387,0.010606081,0.082938865,-0.00089369883,0.03771128,-0.013773979,0.082793914,-0.05755342,-0.018549688,0.016073996,-0.017619211,-0.044654883,-0.084747225,0.03743078,0.037513345,-0.11355418,-0.0015085138,0.03141084,0.009185348,-4.876654e-33,0.106282674,-0.07532651,0.02219613,-0.037915178,-0.023012176,0.06534892,0.08573675,0.0077375923,0.025444534,-0.09084458,0.08855841,0.009669618,0.022932675,0.0090190675,0.03415585,0.012247482,0.015705101,0.093684554,-0.026132919,-0.032429714,-0.0670964,0.04064098,0.00014952905,-0.0281426,0.07005446,0.028375652,-0.03613599,0.06820055,0.0017655995,0.066066846,-0.016152164,-0.028611483,-0.06182995,-0.0007582149,0.014424565,0.05145482,-0.02435252,-0.010100243,-0.0061310404,0.04007395,-0.03323309,0.015786318,0.0799143,0.053129178,-0.023282312,0.08603977,-0.0641866,-0.05149292,-0.026172835,-0.036787573,0.016500227,-0.00037380692,-0.010459798,0.022354132,-0.03002316,0.12030142,0.050207786,0.049532294,-0.034053992,0.04954284,-0.09488743,-0.10258757,0.0715491,0.028473327,0.01241256,0.039473347,0.0020652923,0.04031098,0.09098837,-0.059619844,0.11069047,-0.004580292,0.069909796,0.09100998,-0.04501807,0.00083323114,-0.008576209,-0.070411265,0.016186647,-0.063000135,0.05518729,-0.013359588,0.0014314369,0.00544928,-0.017096203,-0.07670158,0.035353955,0.09435793,0.005469478,0.016763408,0.05077075,-0.031878773,-0.025314907,0.08536132,0.12195754,-5.0929945e-08,0.019347044,-0.051855493,-0.021919323,-0.047350086,0.06265616,0.046677835,-0.03683989,-0.013243242,0.08871382,-0.02362807,0.063629605,0.019812522,-0.06530846,0.0899493,-0.058416534,-0.004294859,-0.038269125,0.07556886,-0.025344925,0.04160401,-0.079642475,0.006728263,-0.12837121,-0.0039466387,0.010225015,-0.061938994,0.0026092634,0.047722906,0.027144652,-0.040426884,-0.07625853,0.034936942,-0.014938126,-0.0017392442,-0.044869285,0.049088515,-0.05590351,-0.013231431,-0.009158468,0.009427822,0.046340972,-0.0098493965,-0.059891,0.00711422,0.042623285,-0.016263837,-0.092262566,0.0022544037,-0.034889765,0.0046206852,0.04748996,-0.0059656897,-0.030910235,-0.11068345,-0.08429026,-0.0023244552,-0.01937444,-0.027910534,-0.04015814,-0.06540219,0.0056443317,0.060542118,0.16306765,0.012323109 +3.5.1.88,Requires iron(II). Also requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. Differs in substrate specifity from EC 3.5.1.31 (formylmethionine deformylase).,384,0.99999994,-0.018839505,-0.1216449,-0.053040914,0.045294058,0.0688897,-0.010948248,-0.0689965,0.05730058,-0.014053963,-0.0509254,-0.027625969,-0.077994175,-0.048160266,0.08555391,0.019013489,-0.012098166,-0.027676716,-0.083548926,0.026668094,-0.005224506,0.046300296,-0.0074407123,0.029251955,-0.052231535,0.053828318,-0.07327226,0.05076783,0.02668679,0.0066547655,-0.026010958,0.0013255976,-0.03912681,0.053447742,-0.037853006,0.020125058,0.05759143,-0.054072738,-0.027419047,0.006981496,0.068332426,-0.0034668744,-0.037427623,0.05829479,-0.072238974,0.038305514,-0.054050703,-0.008188665,-0.017687412,-0.03195606,0.06106482,-0.1044054,-0.0298047,-0.014050513,0.07424355,-0.016988039,-0.0058207978,-0.03201736,0.001041658,-0.03640649,0.013547428,0.017808948,-0.0454346,-0.020002272,-0.08840688,0.033535555,-0.056394506,0.02509835,-0.09804928,0.0819485,0.028758695,-0.045625374,-0.05722555,-0.109261505,-0.00913741,-0.01278909,-0.08909023,0.043623026,-0.047140017,0.051395953,-0.0498162,-0.011913384,0.037279364,-0.0065771635,0.07796212,0.033327393,0.04561146,-0.04070754,0.011352737,0.014555625,0.00033931664,0.01049216,-0.024539586,-0.08565094,-0.04496822,0.018788507,0.038650528,-0.01196054,0.055161506,-0.07643042,0.014637668,-0.0143291205,-0.0026894826,-0.07209616,0.01171528,-0.099921905,0.018733505,0.06470106,0.061059237,0.017423885,-0.0011259053,0.09209672,-0.045616783,0.065645866,-0.022182329,-0.035445128,0.05279656,0.052728076,-0.100130305,0.02267647,0.02828174,0.064531215,0.00909359,0.0903502,0.014394782,-0.008684765,0.038711715,-0.06119281,3.2619116e-33,0.10603562,0.08534801,-0.011532657,-0.0036174275,-0.05794544,0.014175858,-0.12311896,-0.009942972,-0.016141882,-0.080258474,-0.04937521,-0.04739947,0.04230174,-0.0011654819,-0.006828606,-0.020178797,0.066788025,0.0112497425,0.0502043,-0.0019272082,0.06536822,-0.04137902,0.005449411,0.012419149,0.012929047,0.035454214,0.024250604,0.045383047,-0.013449026,-0.010326958,0.014579692,-0.048643164,-0.04824746,0.030475767,0.07181079,0.019528607,-0.07024394,-0.057694517,0.040395096,-0.026134806,0.036146957,0.084956996,0.0115318205,-0.025570463,0.10491179,-0.028819202,-0.05988439,0.0966277,-0.024670865,0.10576685,0.065215915,-0.0064778104,0.13131276,-0.00895047,-0.020896625,0.018124258,-0.030308569,-0.0016287754,0.08296282,0.10225269,-0.023259498,-0.0016338357,-0.012391324,0.09750166,0.0034954853,0.04518853,-0.08593619,0.03984876,-0.0036228085,0.062266577,-0.03992323,-0.004443424,0.03163983,0.030138655,0.037885536,-0.06520805,-0.061694898,-0.009618344,0.04431301,0.016658586,0.00228966,-0.018080844,-0.026514633,-0.020592276,-0.099710606,-0.0014350234,0.015399714,-0.039575517,0.056860387,-0.006128524,-0.03364733,-0.0646567,-0.031722758,0.026671644,0.03742011,-3.7212195e-33,0.026490964,-0.060600266,0.011582523,-0.045523033,-0.0309197,0.06346084,0.016388003,-0.16667351,0.08172616,-0.0055772574,0.07368694,-0.048802853,-0.04892239,-0.06651198,0.04999364,0.059449673,-0.094864525,0.0679954,0.10873673,-0.022472052,0.02792777,0.07563356,-0.05001291,0.020811178,0.09153119,-0.010574533,-0.063853465,0.037609797,0.040592864,0.01668162,-0.070371784,-0.0040058517,-0.0087027205,-0.08997409,-0.0014517251,0.08230146,-0.013904786,0.045345556,0.0354285,0.044279676,0.01004405,0.048548553,0.033292104,0.14066458,0.007326373,-0.0092367185,-0.051771395,-0.064456575,-0.0023029645,-0.051801637,0.016272537,-0.090733625,-0.023177976,-0.06801465,-0.001954105,0.08211031,0.0044279173,0.07267465,-0.022947764,-0.036942456,-0.016251072,-0.037147872,0.009923352,0.009854473,0.022409992,0.038182687,-0.023611788,0.092218265,0.056474194,-0.0026869194,-0.009765804,-0.011117096,0.1406481,0.030852577,-0.03160881,-0.00089765136,-0.047191814,0.05339885,0.013047689,-0.02273258,-0.0047568027,-0.0056432835,-0.023591591,-0.06457599,-0.0025388086,-0.06965984,0.054842483,-0.028678399,-0.036518794,0.014646045,-0.048466843,-0.051613245,0.0247435,0.02122853,0.029388595,-4.2436465e-08,0.08665246,-0.058727805,0.012173331,-0.05696966,0.022548143,0.031497084,0.0122298105,-0.079912715,0.0021832255,0.017726282,0.009044884,0.09344176,0.03164572,0.030990463,0.06705328,-0.003737433,0.009899473,0.05305347,-0.09430318,0.046272747,-0.061470613,-0.0073809503,-0.10277579,-0.015260426,-0.009659538,-0.06660049,-0.015170169,0.046157658,-0.013858132,-0.0035835432,0.015232925,0.011654394,0.012656828,-0.045096673,-0.11000643,0.010745034,-0.051385146,-0.039196968,-0.052538447,0.025114134,-0.009058679,0.009361187,-0.03158092,0.01462021,-0.017693968,-0.048297375,-0.06736793,-0.05360651,-0.029529007,0.043029767,0.011816771,-0.04832215,0.025164777,-0.0209176,-0.057319127,0.08964325,0.013786437,-0.015590007,0.023323208,-0.07679997,0.07166321,0.076567166,0.1621024,-0.06420455 +3.5.1.89,"Involved in the second step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. The enzyme appears to be composed of a single subunit (PIG-L in mammalian cells and GPI12 in yeast). In some species, the long-chain sn-1-acyl group of the phosphatidyl group is replaced by a long-chain alkyl or alk-1-enyl group.",384,1.0,-0.051794395,-0.067751,-0.08362254,-0.0064451974,0.00854539,-0.01617256,-0.05348181,-0.0030661619,0.021707106,-0.009441315,0.04390521,0.061313387,-0.071750864,0.029198699,-0.0821119,-0.031229509,-0.08983993,-0.0060921805,-0.07774178,-0.031412117,0.035855204,-0.038044967,0.017319733,0.065877624,-0.04169355,-0.11665731,0.020194132,0.016819244,0.018215016,-0.033575654,-0.00797869,-0.013672498,0.00403234,-0.019109163,0.003652802,0.06484119,0.023145938,-0.022807159,0.0703355,0.02085126,0.07103291,-0.080659755,-0.007046723,-0.002839769,0.0123473145,-0.003332277,-0.04397494,0.050359085,0.061248302,0.014628345,0.009794917,-0.053069126,-0.07042148,-0.023816088,-0.052295774,0.08055588,-0.10891497,-0.0031594413,0.044975754,-0.01410925,0.05523586,-0.02326761,0.002687986,0.0873366,-0.012954364,-0.04243767,0.0717787,-0.06890501,0.013710884,0.05124959,0.002943604,-0.079341605,-0.08070176,0.03236111,-0.008226944,0.080625266,-0.015477547,-0.021489222,0.050727144,-0.016724037,0.05772424,0.015892042,0.105912805,0.033301055,-0.012635633,-0.06011349,0.021723084,0.049477115,-0.007809545,0.018429037,0.023504516,-0.03153812,0.037377182,-0.022565193,0.054478116,-0.0043785986,0.026758589,0.016921014,-0.0015958579,-0.020146457,-0.019523287,-0.031685513,0.06676345,0.0058874204,-0.06945613,0.046539653,-0.024635838,0.018591532,0.0023780263,0.021332169,-0.0025442324,0.027027588,0.06713356,-0.027247783,-0.033980865,0.027024725,-0.024715481,0.002070969,0.051727716,-0.02682641,-0.029956177,0.016665012,-0.0166949,0.026960017,-0.059437968,0.040177014,-0.071408466,1.8131277e-33,0.05443981,0.05776166,-0.05669997,-0.029516669,0.036659684,-0.0039796513,-0.026722917,-0.02510763,-0.0967239,0.009748637,-0.066447616,0.029160002,-0.0130385,0.09842446,-0.037875336,0.032698832,0.019234866,0.06523656,0.028108744,-0.01757409,-0.0020903053,0.022291122,0.026564905,-0.07874753,0.031772718,0.04808836,-0.088543065,-0.045836803,-0.013313858,0.0078562,0.02856481,-0.11912805,-0.1421952,0.071184434,0.022729162,-0.023077872,0.048563797,-0.083521225,0.091856696,0.006402975,0.013214949,0.023650717,0.009266691,-0.06958657,0.003702939,0.016804254,-0.10503229,0.059733238,-0.017892346,0.06784947,-0.004285382,-0.011286301,0.044218823,0.035250522,-0.09487615,0.048484106,-0.032196667,-0.029349614,0.019918494,0.014482757,-0.0033247555,0.13538106,-0.0077284183,0.04526761,0.072604075,0.015217966,-0.084839396,-0.042361587,-0.01914939,0.06764001,-0.012139423,-0.009594396,0.010340504,0.03190288,0.03815704,-0.06895556,-0.013713724,0.024872111,-0.06375743,0.09774672,-0.028226973,0.001299224,-0.025733579,-0.030382326,-0.06569825,0.00042458146,0.006168046,-0.07598261,-0.05190897,-0.020958837,-0.011337113,-0.065064095,0.023215102,0.08488119,0.01963582,-5.4135725e-33,0.099232666,-0.112507835,0.15283968,-0.06329785,-0.094927676,0.096795864,0.038273823,-0.049852237,0.075962216,0.06124619,0.10411139,0.05090158,-0.0016792626,-0.0047945715,0.040423594,-0.03865911,0.0031828794,0.048778635,0.022711167,-0.06880617,-0.046521887,0.029588968,-0.03981202,0.14045765,0.084590875,-0.081102185,0.04051877,0.038908977,-0.055774353,0.04325257,-0.0010385435,0.016285043,-0.07595742,-0.05303713,-0.012556869,0.037288513,-0.08652965,0.034038987,-0.011081575,0.008990213,0.08274856,0.016271891,0.092068195,0.018873181,0.06932148,0.069175616,-0.047332972,0.070286155,-0.04602947,-0.054387975,-0.017819826,0.020375723,0.022118863,0.02340266,0.0526997,0.084918134,0.04484023,0.01862299,-0.0687353,-0.10293108,-0.015136416,-0.06321146,0.023089763,0.032065555,0.029278064,0.049961653,-0.048274815,-0.09171897,0.04299259,0.0046509122,0.06290317,0.013181075,0.0059382017,0.044592142,-0.017452909,0.033206373,-0.06703528,-0.089867964,-0.0037911285,-0.0871364,0.049690727,-0.059132002,0.036297373,-0.080864705,0.0315585,-0.11831809,0.032476593,0.14934556,0.009705461,0.025691556,0.028077556,-0.027128814,-0.08547736,0.0026675689,-0.009672123,-4.4758526e-08,0.071917415,0.016244445,0.0236082,-0.077048294,-0.06943021,0.020242192,0.058392376,0.011770908,0.032238685,-0.03229934,-0.046511237,0.03339526,-0.0016824548,0.0057576364,-0.0015745304,0.06448392,-0.104739815,0.057661813,0.026480256,-0.007843655,-0.053724386,-0.011934339,-0.028569309,0.016812935,-0.061528973,-0.032902982,0.07307098,0.037362397,-0.011883116,-0.044941183,0.042423896,0.02216556,-0.04858799,0.023891108,-0.012684213,0.003321579,-0.051261477,-0.011382121,0.03243142,-0.017294997,-0.008989613,0.0027257092,0.02948272,-0.037073903,-0.039544873,-0.0018815744,0.029999727,0.029248552,-0.02400347,-0.006828935,-0.026785597,0.021474004,-0.06955026,-0.048851192,-0.08496042,-0.02074881,-0.07695852,-0.0650081,-0.0076482818,-0.01676482,-0.042285614,0.02024082,0.11185195,-0.10493933 +3.5.1.90,"Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB).",384,1.0,-0.014230902,-0.041837938,-0.06722649,-0.098503284,-0.0059398687,-0.02280952,-0.035433233,-0.020269806,0.017628266,0.01672742,-0.012995915,-0.048745412,-0.0052200323,-0.04837223,-0.060344484,0.017692534,-0.02365703,0.03920203,0.044569712,0.034508068,0.0072673988,0.0939372,-0.02699958,0.028707562,-0.031340856,0.016239345,0.06913788,-0.028973343,-0.06236069,-0.05731307,0.016827278,-0.028940221,0.07420619,-0.043219835,0.08016235,0.135204,-0.033043064,-0.02333434,0.035950173,-0.019114193,0.07589778,-0.008612197,0.040656462,0.00082374725,-0.02866291,0.011541721,0.019491654,0.021463662,0.08989963,-0.05456698,-0.023005065,-0.03779356,-0.12585002,0.024590882,-0.0032695548,0.095111914,-0.086836755,-0.013358519,0.032552525,-0.014739257,-0.042565573,0.056903,0.05774383,0.063593745,0.04334691,-0.026399039,0.07840483,-0.07502684,0.041353233,0.002107885,-0.042612337,-0.03141249,0.02643083,-0.04937508,-0.04550944,0.034000766,-0.082965545,-0.012255365,0.020286513,-0.069122784,0.023261942,-0.018932981,-0.0408948,-0.016357236,0.04844929,-0.012383981,0.023266502,-0.015947185,0.070158996,-0.034203436,0.040392123,0.003652876,0.07989482,-0.066848785,-0.02564647,-0.048686728,0.051555887,0.0670602,0.0077000502,-0.058451544,-0.037467666,0.070566416,-0.06498796,-0.089442305,-0.045767162,-0.04938754,-0.032143526,0.1587148,0.05136522,0.11219755,-0.056859974,0.034812424,0.048645683,0.0036139465,0.028879056,0.05221398,-0.018161202,-0.07690137,-0.086529724,0.004364599,-0.06657908,-0.031557065,0.07212576,0.03671841,-0.015437896,0.033568896,-0.026164876,7.373174e-33,0.07901667,0.016134808,0.07026118,-0.021813314,-0.00654718,-0.010675485,-0.08665251,-0.030927556,-0.033804387,-0.073897414,-0.015537789,-0.04420024,0.055586573,0.014464216,-0.052952092,-0.020041892,-0.040071588,0.047436323,0.035993077,0.062396597,-0.04205923,0.08370375,-0.028647281,0.06382502,-0.003982115,0.0035396721,0.013700419,0.031342365,0.051013183,0.00034423757,-0.018029405,-0.053679354,-0.14082064,-0.0320774,0.018322034,0.0025297513,-0.035809513,-0.043088734,-0.036370095,0.035657223,-0.08464166,-0.025233721,0.00040057182,-0.03889518,0.046193223,-0.01644799,0.022608701,0.10740364,-0.029782599,0.048467953,-0.024250818,-0.037606895,0.08367617,0.018712478,-0.09571132,-0.021745466,-0.023803411,-0.035031002,0.03640064,0.090012915,0.041423444,0.07960797,-0.03265914,0.048347108,-0.07879149,-0.012297933,0.014721818,-0.0060740607,0.014910943,0.019035328,0.019727726,-0.068817265,0.02736953,0.09217249,-0.028733024,0.0076826788,-0.031906452,-0.081141554,-0.030227378,-0.0020786088,0.021321127,-0.04809781,0.06703568,0.0024909605,0.05395438,0.013338343,-0.013588645,0.0043779765,-0.04218323,0.027742457,0.0929449,-0.062180746,-0.06327477,0.035358675,0.016501524,-7.579636e-33,0.14789677,-0.06901453,0.039310385,-0.08642881,-0.10587899,0.048363432,0.044859387,-0.042897668,0.054329783,-0.09697403,0.035268128,0.035829797,0.051439576,-0.09367914,-0.052967604,-0.12851308,0.02687546,0.04504773,-0.013164497,0.019515058,0.118529536,-0.05725947,-0.0145832,-0.030895853,0.008715933,0.031198733,0.058751103,0.13447233,0.008319767,0.011052878,0.01756948,0.032186817,-0.09296092,0.021201251,-0.08816373,0.02188084,-0.038678434,-0.010282091,-0.022579204,-0.039335143,0.01285197,0.06931528,-0.050515104,-0.015932916,0.04932284,0.05515034,0.010086721,0.07673503,0.06385132,-0.0005310704,0.028802786,0.0036619878,0.042284973,-0.025208315,-0.0018327585,0.034639943,-0.0014123503,0.014205423,0.02778834,-0.049274933,-0.035158996,-0.011608592,0.052196395,-0.015196992,-0.03687267,0.046666887,0.058821283,0.051364847,-0.036641672,-0.0016739223,0.024899228,0.060424667,0.031343546,0.07256913,0.0065890425,0.014848779,-0.031786192,-0.04927157,0.02513712,-0.050749186,-0.040386453,-0.016948165,0.08022434,-0.046641838,-0.015734361,0.03509168,0.04363485,-0.020787606,-0.027591828,0.025388492,-0.068604514,-0.0462586,-0.010742625,0.005028315,0.03929949,-4.3331735e-08,0.041957356,-0.00428819,0.068690486,-0.0870675,0.06256911,0.08468619,-0.007052523,0.016234454,0.064480275,-0.08914902,-0.021982638,0.064646065,0.0016132636,0.056292046,-0.02402548,0.065700576,0.0021872194,-0.048276532,0.0032150904,-0.09528302,-0.08121665,-0.06972039,-0.027212603,0.06500004,0.017181428,0.006471875,0.059794594,0.05405835,-0.036888957,-0.048012327,-0.028992387,-0.048056148,-0.0020058055,-0.051167168,0.045099303,0.013117351,-0.05112202,0.0049027503,0.00513183,-0.007914935,-0.030519994,-0.0070717824,-0.049321957,-0.012163762,0.05409072,0.048593756,-0.021364314,0.08619047,-0.067603655,0.0020951754,0.10035599,0.007672105,-0.021504162,-0.11028108,-0.061689716,-0.020691168,-0.035359934,-0.12042847,-0.029354682,0.017858703,0.006399393,-0.049147803,0.10723058,-0.04947504 +3.5.1.91,"Zinc is a cofactor. While N-benzylformamide is the best substrate, the enzyme from Arthrobacter pascens can also act on the N-substituted formamides N-butylformamide, N-allylformamide, N-[2-(cyclohex-1-enyl)ethyl]formamide and N-(1-phenylethyl)formamide, but much more slowly. Amides of other acids do not act as substrates.",384,1.0,-0.07252405,-0.06362507,-0.0673072,-0.048605897,0.00470078,0.05915612,-0.030652924,0.017370177,-0.011362558,-0.009834088,0.043172773,-0.0098129045,-0.022721445,0.070269234,0.01972403,-0.0063879094,0.03620446,-0.03683504,0.046219572,0.013276014,-0.008387511,0.060300935,0.0034696348,-0.0849793,0.0015915126,-0.005379254,0.06152016,-0.0053329235,0.09742149,-0.059900057,-0.02060734,-0.021400668,0.039974336,-0.026581053,0.028929401,0.017484082,-0.034874722,-0.024115343,0.019167902,0.039132416,0.027487785,0.09294007,-0.012543996,-0.10076059,-0.004561514,-0.06970431,0.024842242,-0.014815079,-0.007146483,-0.0118742995,-0.041451536,-0.07731081,0.021626553,0.030734994,-0.04010523,-0.013527288,-0.10472518,-0.057063367,-0.062055677,0.014122844,-0.012252008,0.010439672,0.035650663,-0.06126957,-0.028996466,0.048114777,-0.036475893,-0.07550555,-0.051861268,-0.03752836,-0.12037059,-0.03236571,-0.03185971,0.024782583,-0.05444478,-0.033951778,-0.005467532,-0.07508098,0.019176356,-0.040256295,-0.00075909146,0.05286323,-0.019737318,0.0842453,0.07978021,0.05241649,-0.037060652,0.03764566,0.08036758,-0.0039300644,0.040781792,0.05252524,0.015534147,0.016603999,-0.09188636,0.009081285,-0.012627096,0.08224642,0.03698204,0.0057501793,0.047087755,0.09389698,-0.025194746,-0.12338134,-0.08505092,0.05191753,0.045791347,0.06868608,0.04069557,0.041592285,-0.056443445,-0.010093574,-0.043480493,-0.042664275,-0.039169863,-0.0038091415,-0.0022544153,-0.06539249,-0.024012977,-0.093692616,0.0059106136,-0.050923873,0.04894443,0.011066106,0.03591385,0.07204222,-0.090330884,3.7762025e-33,0.06732802,0.059295118,0.016434578,0.0015378946,0.034265224,0.027717667,-0.03472724,0.052876968,0.02005138,-0.09655943,-0.062014244,-0.02242824,0.0047126478,-0.019402951,0.012092708,-0.020008467,-0.011620194,0.08671875,-0.019674495,0.020650592,0.08157438,0.041470576,-0.033321593,-0.016692068,0.023921246,0.0075315027,-0.031497523,0.036069736,-0.047536522,-0.045737475,0.007907587,-0.057224546,-0.06935136,-0.010933771,0.12031128,0.016200844,-0.04916891,0.009342368,-0.03700849,-0.04447138,-0.018407099,0.026210444,0.0017047718,0.030639406,0.07022618,-0.04322759,-0.06452005,0.09154987,-0.035054762,-0.02910039,0.059011947,0.026106276,0.038355295,0.024703292,-0.05036781,0.07281063,-0.034630638,0.0076693855,0.022967529,0.00057330844,-0.014186344,-0.01129428,-0.050261218,0.042166542,-0.04928318,0.028717466,-0.05303628,-0.037777696,-0.017178161,0.06672257,0.03127368,-0.03481918,0.016385842,0.13681482,0.076479904,-0.10828946,-0.04591329,0.0047623357,0.11878257,-0.009747025,-0.034377933,-0.005305086,-0.02602505,-0.050098464,-0.055901203,-0.051447704,0.0052271252,-0.031903166,-0.0051814313,-0.013596151,0.006908991,-0.062134333,0.0002304655,0.02069739,-0.01236137,-4.786066e-33,0.0778434,-0.035634223,0.0036011245,-0.03788893,-0.0007419081,-0.06401521,0.073735036,-0.023708727,0.026894987,-0.00214105,0.0773922,0.03250334,0.061651383,-0.0071493853,0.050995313,0.045166686,0.016113168,0.0988243,0.06390794,-0.0914426,-0.04498779,0.053277105,0.06313478,-0.029635092,0.0066703795,0.04181927,0.005510491,0.08521953,0.07455335,0.07984913,-0.024821492,0.048033427,0.040099457,-0.13919991,-0.053144064,0.106157385,-0.05704282,-0.041785203,-0.03883854,-0.043303497,0.036159836,-0.005599208,0.009899504,0.13871697,0.012874563,-0.002016049,-0.10659546,-0.023991795,-0.044031825,-0.010073933,-0.010194648,-0.0059225513,0.0014255573,-0.047748737,0.04478391,0.15288197,0.01264657,-0.00039527376,-0.034026954,-0.0070705796,-0.015398748,0.027855242,-0.007670035,0.009683198,0.006536714,0.012364573,0.0528366,0.08035442,0.057518963,-0.022509202,0.018157197,0.061979614,0.03543124,0.044462718,-0.081059456,-0.021875797,-0.01502098,-0.029435715,-0.016049586,-0.002551779,0.0054285815,-0.041532833,-0.040962014,0.0037248924,-0.09205814,-0.023518724,0.04586455,-0.0038168188,-0.066573486,0.074601434,-0.053128924,-0.046056207,0.06040059,0.10967585,-0.049591925,-4.5138787e-08,0.00967004,-0.030845365,0.04564454,-0.14119738,-0.040001627,-0.013492056,-0.046946358,-0.07677114,0.021312231,-0.029259732,0.08130669,0.059885446,-0.03408763,0.073942214,0.03904653,0.013410787,0.00039919844,-0.013103891,-0.07853974,0.046695024,-0.05456189,0.06793877,-0.053823747,0.0012561448,0.009291706,-0.04668383,0.046196003,0.0670401,-0.03252665,0.026205856,-0.052894846,0.029978659,0.058691997,0.0095329415,-0.015300594,-0.0059589287,-0.014136834,-0.11608725,-0.019886572,0.066862464,0.016583594,-0.008911922,-0.049336936,0.004081564,0.07106935,-0.050267253,-0.041514687,-0.011433092,-0.0107498,0.028848642,-0.031109653,-0.058489375,-0.03544509,-0.12040484,0.0069447444,-0.013074775,-0.04991101,-0.019022046,-0.011557726,0.031949487,-0.02182116,0.059825454,0.21916452,0.042618252 +3.5.1.92,"The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant [5].",384,1.0,-0.040577013,-0.039138418,-0.044730388,-0.08971976,0.07848997,0.08007856,-0.023230499,0.054953165,0.028971491,-0.023806393,-0.056339428,-0.008524533,-0.0063963686,0.027630735,-0.069285385,0.031291746,-0.04523321,-0.008477245,0.008912915,-0.042679228,0.017107021,0.035474997,-0.031025521,0.051559232,0.06912717,0.0081901,0.048274063,-0.05099286,-0.045834035,-0.014990671,-0.0076360726,0.029279007,-0.038832795,-0.023931928,-0.01653083,0.06635088,-0.042927675,-0.013428554,-0.026682695,-0.053945612,0.075051576,0.017508572,-0.01001754,-0.061165947,0.023201583,-0.0153812645,-0.062686324,-0.018924613,0.010614611,0.056029674,-0.052522458,-0.065232106,-0.02181253,0.030432824,0.033321414,0.05873366,-0.05906958,0.006226117,-0.02845158,0.032919887,0.005660684,-0.0090561,-0.0717482,0.016073277,0.034519915,-0.0071681794,0.036453314,-0.02921578,-0.026046036,-0.019673571,-0.038445167,-0.07282812,0.06927265,0.0023331284,0.03951254,0.0053338315,-0.051853877,0.0032531149,-0.015338267,-0.052551683,-0.08663132,0.017394949,-0.0056621903,0.16101198,0.03570751,0.037022922,-0.03635751,0.03231967,0.089995615,-0.030227449,0.04410353,0.06691088,-0.045133848,-0.058326773,-0.1093506,0.010165644,-0.033226456,0.0058884965,-0.020810068,0.045741886,0.0792311,0.0753477,-0.047394615,-0.072612114,-0.12043013,-0.010704985,0.03950868,0.02336254,-0.0075629344,-0.022165215,0.051641572,0.013275197,0.049650416,-0.063309036,-0.02031784,0.050141543,0.030375447,-0.08778062,-0.036539722,-0.015707111,0.046363015,-0.008783973,0.08848659,0.056468286,-0.061324302,-0.021056013,0.00886892,2.5271599e-33,0.013437882,0.058180064,0.080599464,0.028276842,-0.0049235984,0.010669624,-0.020380968,0.063385315,-0.04567464,-0.11377347,-0.073470764,0.0068929135,0.024978215,-0.011753948,0.044561073,-0.041682992,0.046314683,-0.017104411,0.0610272,-0.019676115,0.032580238,0.07156878,-0.054181233,0.05814221,0.008940093,-0.012864991,0.035761505,0.06405189,0.018864933,0.022865081,0.025098324,0.032367084,-0.032428544,-0.013104477,-0.036805272,0.0126227075,-0.0894918,0.004230062,-0.016488492,0.12494176,0.037061837,-0.01068742,0.0010098044,0.044794135,0.032196403,-0.07692606,-0.031128012,0.070046626,-0.016323939,-0.01580345,0.018761573,-0.043944996,0.07166279,0.030974425,-0.10926693,0.10698466,-0.013704798,-0.040708624,0.056613434,0.057331424,0.015366445,0.0517205,-0.068086416,-0.010604174,-0.07974658,0.045786534,-0.04766608,-0.034110617,-0.042437714,0.07057101,-0.004985601,0.023071796,0.05099958,0.11215211,0.0691664,-0.10367295,-0.013368078,0.022038648,0.006510998,0.00082127994,0.099684216,-0.04924447,0.024802491,0.06191634,-0.044572517,-0.029606888,0.017342873,-0.006954814,0.010919547,0.02831977,0.10008334,-0.11178544,0.045789346,-0.028260082,-0.05760929,-1.9506998e-33,0.038531106,-0.11221551,-0.018196916,-0.022955466,-0.0228657,0.018224666,0.06185467,-0.076388374,0.003992707,-0.00060297473,0.078479625,-0.0038451634,0.007829112,-0.025467465,-0.02988824,0.01736847,0.048942372,0.04938154,0.005282372,-0.006246411,-0.04392589,0.026292695,0.049438998,-0.014479657,0.04997954,0.04967611,0.00464559,0.07893062,0.053533755,0.0756896,-0.024462063,-0.02634944,-0.031303145,-0.055239797,-0.010572859,0.11983195,-0.026643055,-0.029332006,-0.046746153,0.03639597,-0.05978887,0.016751125,0.06486234,0.013631196,0.063601725,-0.008288704,-0.1378532,0.054487877,-0.032852862,-0.04544618,0.03330672,0.042557355,-0.012237631,-0.035910714,0.055285167,0.02182214,-0.008296454,-0.051027432,0.06683017,-0.09724261,-0.019684346,-0.027750984,0.023118924,0.03444473,0.07084416,0.029146364,-0.08240016,0.11638218,-0.04779398,0.00026434803,-0.056646753,0.0054341424,0.09432502,-0.034945462,-0.06717297,0.00467565,-0.040384665,-0.003930469,0.011320389,-0.025079142,0.014546541,-0.041270614,0.038108937,-0.10943149,-0.09661246,-0.063553095,0.03710227,0.09859902,0.004070415,0.030325016,-0.04705781,-0.0070854183,-0.04562203,0.084213465,0.08343783,-3.4450665e-08,0.07653378,-0.116104834,-0.012578686,-0.045948725,-0.048942465,-0.03979406,0.054081213,-0.052304022,0.07552862,-0.05342819,-0.10060526,0.035308555,-0.01065341,0.007424714,-0.040800057,0.08319534,-0.021884648,0.020852517,-0.045954887,0.022068167,-0.046345655,0.039292645,-0.08590509,-0.025004385,0.04071753,-0.017381532,-0.017216144,0.018177444,0.005028901,-0.04424016,-0.034978725,0.0049431473,-0.007504813,0.014182042,-0.021571161,0.06190415,-0.04094539,0.03467415,0.010674447,0.013767729,0.0037535527,-0.07316349,-0.049511135,0.043234494,0.066083476,-0.023502124,0.034067236,-0.0040527554,-0.0025794515,-0.0031775618,-0.024539456,0.027566364,0.039292734,-0.026732566,-0.06045967,-0.060664188,0.03330174,-0.10143176,-0.028272964,-0.095541924,-0.034075223,0.0048316545,0.21355067,0.05806174 +3.5.1.93,"Forms 7-aminocephalosporanic acid, a key intermediate in the synthesis of cephem antibiotics. It reacts only weakly with cephalosporin C.",384,1.0,-0.018758701,-0.015618839,-0.019223554,-0.06590779,0.015797136,0.11840111,-0.042722788,0.09157761,0.08801687,0.07134686,-0.0009378402,-0.15628052,0.028446745,0.08270713,-0.046401907,-0.06447984,-0.07441032,-0.039876547,-0.024180189,-0.003604982,-0.03603895,0.039960425,0.03434517,0.03343134,0.05082162,0.04508547,0.06331546,0.020253295,0.024468366,-0.08254192,0.07780212,-0.016667644,0.032437693,0.008915165,-0.012374424,0.020638062,-0.02253465,-0.08914988,0.07318038,-0.031761836,-0.02082581,-0.011258638,-0.0024213132,-0.04488926,-0.0035590262,0.05131975,-0.006014987,0.034328677,0.069601476,0.021947661,-0.011963102,-0.03708872,-0.08078539,0.07420318,0.0074344124,0.041423433,-0.07251069,-0.053130493,-0.008426846,-0.045249555,0.044649344,0.005884459,0.050210655,0.015003263,-0.07550676,-0.011799965,0.011416946,-0.08865381,0.039860953,-0.0010752592,-0.09068876,-0.08840921,0.09862875,0.086836904,0.0010538817,0.04130605,0.06001764,-0.103166245,-0.041691747,-0.12438379,0.04717576,0.03210068,-0.05300618,0.0666506,0.05160435,-0.010852515,0.08101096,-0.007925015,0.073100396,0.021569585,0.05434327,0.039598595,0.004863661,-0.08878764,-0.021679372,0.034576926,0.04054368,0.020575244,0.03323984,-0.004645565,-0.024376106,0.071546294,0.022021074,-0.071095556,-0.013564557,-0.040189046,-0.0076932716,0.043536738,-0.026976353,-0.08600334,0.0060299058,-0.11393121,-0.027413463,-0.028445438,-0.042649277,0.09635134,0.067195825,-0.07015087,-0.041098524,-0.027602581,0.024302287,-0.06765073,-0.013447774,0.030857041,-0.10534788,-0.042071477,-0.048028734,1.3322262e-33,0.053175606,-0.0058055827,-0.014887684,0.029966816,0.060319625,0.023118408,0.011740636,0.034013376,-0.017709203,-0.108893715,-0.066065736,-0.057761583,0.016745754,0.008836037,-0.041050434,-0.027762856,0.008855985,0.009889149,-0.015424814,-0.10418678,0.04215282,0.06283056,0.004465026,-0.041395724,0.0578988,0.06449724,-0.03494229,0.065191455,0.06072566,-0.020077344,-0.0683232,0.03226046,-0.05920659,0.016673954,0.033785723,0.017871374,-0.062910445,-0.05885889,0.06896062,0.095851295,0.03869822,0.005459167,0.005251344,-0.003027456,0.026685057,-0.008646398,-0.08246429,0.026168454,0.056336317,0.006034176,0.12260425,-0.08395846,-0.0038701724,-0.016033571,0.01844694,0.0398512,-0.10495227,-0.03647417,0.025959525,-0.03196527,0.017380025,0.037283983,-0.07744292,0.021940265,0.073335275,-0.051705215,-0.050073683,0.025695834,-0.041822065,-0.06513773,-0.01570042,-0.014569778,0.040999096,0.07286653,0.02728778,0.0220315,-0.07919175,-0.049949754,0.056227338,-0.047152467,0.024157383,0.014463119,-0.061801177,0.012192044,-0.01025517,0.059563775,-0.024186252,-0.022765592,-0.06475432,0.009932163,-0.022847034,-0.0727718,-0.047054473,0.021041447,-0.0544211,-1.850692e-33,0.10074566,-0.047359806,-0.06567918,0.013589728,-0.0504632,0.055312246,0.017337693,-0.094373286,0.019197978,0.026371637,0.08075126,-0.06750038,0.06903143,-0.052414134,-0.030970637,-0.032519273,0.05941698,0.05769516,-0.04389502,0.032505225,0.04362057,-0.020892983,-0.05787747,0.0058974004,0.08034745,0.016005099,0.015077193,0.0734871,0.016324509,0.09780639,-0.05815203,-0.05287515,-0.04959913,-0.03097981,-0.028329682,0.014654893,-0.0522587,-0.012573942,0.026194636,-0.034071304,-0.013608357,-0.033565868,0.048627093,0.048966624,0.1012145,0.046739783,0.06868045,0.0057717566,-0.005092042,0.025166757,0.08177183,-0.06836089,-0.030490112,-0.018042685,-0.05260968,0.085606776,-0.010395965,-0.0015107014,0.10490995,-0.079605766,-0.0021226953,-0.0024472638,0.060692854,-0.03221142,0.044610918,0.055106174,-0.08055708,0.07404835,0.09448149,-0.12367131,0.068768546,-0.08714819,0.040699076,-0.039832857,-0.01179284,-0.07466305,-0.02859568,-0.050160922,0.055462714,-0.039162014,-0.020451104,0.030355696,0.040233955,-0.045999482,0.009115754,0.0290473,0.02525557,0.00016839766,0.053214762,0.035398107,-0.022958433,0.05858606,0.011457373,0.053280924,0.06907403,-2.6626111e-08,0.047363285,0.0065420815,0.0060106535,0.008574331,0.10337645,-0.012033108,0.0072838524,-0.10402983,0.01278623,-0.064086474,0.0011911638,0.03585463,0.020441,0.045585252,-0.023265218,0.06436399,-0.040215693,-0.0026599634,-0.007053377,0.008663275,-0.047488455,-0.030795338,-0.04282922,0.02656667,0.048761427,-0.004159093,-0.0046719913,0.050562777,-0.05508968,-0.03767041,-0.0038775376,0.031788047,-0.019805046,-0.016109211,0.042749796,0.013346143,-0.008165838,-0.020985523,-0.011828976,-0.0020441501,0.041838937,0.036175955,-0.011220862,0.027460834,-0.002299855,0.03571986,-0.025460484,-0.006426716,-0.06720958,0.014252658,0.08087814,-0.005104654,0.031186469,0.022366308,-0.09026187,-0.024377905,0.007073968,-0.041611575,-0.060417667,-0.0670737,-0.021192377,-0.0070516253,0.15311964,0.07084368 +3.5.2.1,"Contains zinc and is specific for barbiturate as substrate [3]. Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.1.95 (N-malonylurea hydrolase). It was previously thought that the end-products of the reaction were malonate and urea but this has since been disproved [2]. May be involved in the regulation of pyrimidine metabolism, along with EC 2.4.2.9, uracil phosphoribosyltransferase.",384,0.99999994,-0.00791165,0.025252543,-0.03060995,-0.05107041,0.025299728,0.027035356,-0.0020194056,0.059989918,-0.022494005,-0.026816923,-0.04465974,0.0055470085,-0.058427393,0.012268071,-0.05275784,-0.023479434,-0.09028185,0.000117306925,-0.012998751,-0.07214861,0.10848864,0.067687154,0.0032072507,-0.038945206,0.006891379,-0.014546964,0.050319098,-0.020541592,-0.011484274,-0.030234527,0.015610226,-0.11242645,0.03538181,-0.10679221,0.055131976,0.09840828,-0.03039592,-0.051690083,0.004073638,-0.024898479,0.07485494,-0.0006143567,-0.053813376,0.049015276,-0.030246995,0.028115198,0.030258013,-0.011286,-0.032779355,-0.009093298,-0.09629574,0.008247121,-0.02399159,0.017966978,0.047527418,-0.016805355,-0.07498183,0.02829706,-0.033293564,-0.034252513,-0.026291046,0.011898054,0.02697392,-0.0524528,0.043331433,0.013110794,0.04630373,-0.07160451,0.03753465,-0.090687595,-0.04119587,-0.09190605,-0.0043047015,0.041197482,-0.043369416,0.0028416202,0.035373423,-0.05090169,-0.028006546,-0.030737435,-0.02175386,-0.087392464,0.028588783,0.012355202,0.012714031,-0.04743823,-0.074477,-0.048706315,0.033278063,0.0804838,0.040756214,0.0048428015,0.023179198,0.00041057818,0.013251158,0.061386716,-0.006472552,0.0005989949,0.03876037,-0.033066142,-0.004072814,0.07034223,-0.06502597,-0.050281633,-0.044910755,0.04190608,0.05189287,0.10517781,-0.012389949,0.020935664,-0.01569554,0.058745857,0.027313612,0.038650487,-0.046844654,0.049376577,0.012169782,-0.054798685,-0.089864954,-0.010145418,0.0047395485,0.02018438,0.028617755,0.056645878,-0.0873165,0.008146465,-0.072599724,4.4891167e-33,0.032168824,-0.00454419,-0.014391412,-0.057399545,-0.002488577,0.05832611,-0.057608534,0.0095633045,-0.00935976,-0.13508298,-0.069244586,-0.14072573,0.019944258,0.029601038,-0.055488463,-0.06908497,-0.032797508,0.06412777,0.10443529,-0.0039397758,0.021247992,0.06488441,0.0060083796,-0.012203541,-0.008874214,0.06945556,-0.012589943,0.01628329,-0.02227227,-0.012303484,0.034135267,-0.068252735,-0.050949782,-0.022908727,0.08857808,0.028236555,-0.024757672,0.0269198,-0.0024388372,0.019076677,0.025352413,0.004195473,-0.0013095257,0.0214718,0.009139575,-0.093451954,-0.081161655,0.06990985,0.014211064,0.05440223,-0.062063325,-0.033141833,0.049914513,0.016181132,-0.0436357,-0.03332859,-0.06968421,-0.037744276,0.022945646,0.006349515,0.05067581,0.16565274,-0.004769038,0.02046728,0.025112804,-0.050152283,-0.022292426,-0.031160442,-0.010832008,0.031986978,-0.04731994,-0.027384998,0.08637029,0.021679267,0.02835099,-0.10821438,-0.08774661,0.07240005,0.001901655,-0.019107953,0.030087499,-0.0059863,0.022056656,0.007433348,-0.01721908,0.039398912,0.0020691075,-0.07981111,-0.0018744037,0.042110454,0.017635075,-0.07918626,-0.061658952,0.0041814963,-0.0211043,-5.0748174e-33,0.14602685,-0.0823873,0.07995963,-0.05492445,-0.021210643,-0.0144719565,0.06794426,0.0063132425,0.0040597506,-0.017776435,0.07601431,0.013022896,0.03348438,-0.116541244,-0.030098896,0.006553329,0.05964975,0.09232953,0.055153158,-0.050684705,-0.010631972,0.040074643,-0.050516788,0.06955494,0.03563814,0.012271142,0.04204126,-0.011783438,0.04959633,-0.025756903,0.0136432685,0.06519972,-0.06742967,-0.07074294,-0.009064014,0.039979044,-0.08066789,-0.024311343,-0.014367948,-0.03977315,0.072292574,0.05625773,0.0019900377,0.015542439,0.08449256,0.07001501,-0.062673405,0.014283628,-0.049949434,-0.026439019,0.107069775,0.0549525,0.009810814,0.045532756,0.11143722,0.0049200146,0.008388514,0.053906634,-0.008270311,-0.027775344,-0.016413497,-0.011954654,0.02831545,-0.022840017,0.08790978,-0.005193755,-0.021068018,0.05863362,0.040124867,0.047892787,0.07431374,-0.015884094,0.051354155,-0.0056136935,-0.098662324,-0.023256043,-0.07464521,0.010261313,0.030536683,-0.005700933,0.054492697,0.027228337,0.060401898,-0.043384448,0.030676363,-0.07864816,-0.018698083,0.09951761,-0.04933591,0.0105121145,-0.06507726,-0.14528775,-0.07803987,0.025675831,0.1006232,-4.8203265e-08,0.023991438,-0.050032455,-0.047363997,0.001844019,-0.04966209,0.03233542,0.015917804,0.030848874,0.025865454,-0.055126674,0.07042678,0.024045909,0.047110997,-0.006253512,-0.0011127605,0.032324642,-0.026732834,0.07270193,0.019101761,0.034817647,-0.074872084,-0.0072995652,-0.12771748,0.030440995,0.04258596,-0.035874598,0.03532979,0.03070961,-0.0036008996,-0.07831281,0.031091886,-0.03399905,0.0856853,-0.02787864,0.012808872,-0.0051914495,-0.010862041,-0.032092813,0.009304994,0.04572339,-0.09063844,-0.034602907,0.017683115,0.048438672,0.03940737,-0.005387722,-0.031438444,0.08313451,-0.048812687,-0.022931563,0.083971374,0.00069957826,0.024576524,-0.12390375,-0.06378466,0.050003607,-0.022256529,-0.10565375,-0.0068802093,-0.012873715,0.10347302,0.017933818,0.13712241,-0.0059972685 +3.5.2.2,Also acts on dihydrothymine and hydantoin.,384,0.99999994,-0.012261036,-0.019690195,-0.0067172474,-0.0017682224,0.044156123,-0.025560724,0.02817415,0.04548874,-0.0006289906,0.013636704,-0.001539775,0.02044387,-0.030338781,0.07288268,-0.004055967,0.07735062,-0.096485265,0.0141822575,0.0034384967,-0.024265947,0.022368032,0.03552527,0.015263171,-0.016792627,-0.033401586,0.050901596,0.054630715,0.07457984,0.014691454,-0.0037807731,-0.036009863,0.028480027,-0.023052713,0.0045835553,-0.029989045,0.1406068,-0.067,-0.0010356692,-0.017052555,0.040248305,0.06600059,-0.08416871,-0.006266566,0.01124671,-0.06883881,-0.04507583,-0.061149422,0.015940018,0.07049583,0.08404644,-0.03201333,-0.029749075,0.07126148,0.079392426,0.01681571,0.009537936,-0.1102302,0.072281495,-0.018740151,-0.041674968,-0.1001461,0.0042829216,-0.0015093625,0.008240699,0.031113653,0.0036154748,0.020395603,-0.044703886,0.002873297,-0.020407617,0.07405985,-0.039472826,0.060796313,-0.012059759,-0.019826258,0.012810681,-0.060563345,-0.10000679,-0.044841804,-0.050338477,-0.0024554161,0.060092364,0.03652455,0.025718236,0.04437838,-0.011194562,-0.0042486847,-0.035410855,-0.08044116,0.021340514,0.023421623,-0.05204857,-0.037873793,-0.04560827,-0.05408307,0.0026787624,0.0023923314,-0.020353347,0.0038146493,0.019649474,-0.0620912,0.014983676,-0.10263324,-0.030360028,-0.019125458,0.032915846,0.0036822176,-0.03672959,-0.07659123,0.02394656,-0.016328476,-0.0025075262,0.02762637,0.062381204,-0.01846117,0.10391174,0.04528726,0.03592488,-0.08256054,-0.015416006,0.009631056,-0.08300419,0.042196717,0.03223835,-0.008498579,0.012048272,-0.087592304,3.5092076e-34,0.057901632,-0.049511015,0.022761438,-0.0066955085,0.057969555,0.016388172,-0.045962982,0.017114485,0.07237021,-0.04332864,-0.05307422,-0.013741992,0.079457045,0.0048690666,-0.08127076,-0.0691885,-0.035511486,0.0041546295,0.044418693,0.007290928,0.04965071,0.08341178,-0.038243867,0.03457341,-0.08822035,0.05528892,0.012767643,0.040517967,0.043913692,-3.372107e-05,-0.042029567,-0.11367594,0.004219172,-0.0019296772,-0.0070797564,0.12521715,-0.06421595,0.008654435,-0.035227004,0.025296282,0.011934904,-0.035422448,-0.07641616,-0.029073078,0.019763295,-0.013836308,-0.040535327,-0.05351396,-0.018689256,0.019778784,0.04863175,-0.05727523,0.0617243,-0.09110218,-0.073771276,-0.016845614,-0.0035124915,-0.11836758,-0.009442492,0.07120182,-0.0051037828,0.025952969,-0.04009876,-0.008999275,-0.016079227,-0.035811767,-0.029086964,-0.07476552,-0.06862125,-0.0037528928,-0.053999666,0.0037182772,0.13515542,0.03496308,-0.030157574,0.020730736,-0.034563154,-0.025667483,0.012825535,0.0033688801,0.020612255,-0.09339473,0.1155271,0.024186406,-0.0027165208,0.01281096,-0.029905908,-0.11746083,-0.043398134,-0.019735366,0.064810865,-0.06027027,-0.01598144,-0.06989097,-0.021037465,-2.7936595e-33,-0.005411257,-0.044456374,0.058894858,0.0011240264,0.017412167,0.11466328,0.018573338,0.06521198,0.0053590424,-0.040018123,0.06429595,-0.07263813,-0.09771074,-0.017621435,0.029497718,0.0745795,0.014189937,0.0875465,-0.07691,0.029437995,-0.059820775,0.08595191,0.02944693,0.08087249,0.084972754,0.030547032,0.025438774,-0.0020448845,-0.012378768,0.119501464,-0.045249786,0.021155447,-0.13977733,-0.06530882,0.024267143,0.049200576,-0.07280736,-0.046597134,-0.06643378,-0.05919214,0.023891613,-0.059460487,0.09708285,0.07741008,0.00512128,0.08736495,-0.03144803,0.03555032,-0.07367086,-0.038885668,0.016864728,0.040553242,-0.02352436,0.029596794,0.057458933,0.03651716,0.017247802,-0.04995326,0.0035428558,0.048827406,0.0020509204,-0.032407437,-0.042928524,0.030999523,0.024576833,0.019370703,0.0063573257,0.014694462,0.09172993,0.008804989,0.09076,0.006058088,0.051597454,0.08127109,-0.09095083,-0.016880348,-0.046186633,-0.05203669,0.01990639,-0.031096874,-0.04566765,-0.022837168,-0.025171708,-0.011050763,-0.053457804,-0.04376525,0.012724613,0.042909954,-0.047288377,0.030482208,-0.007502243,0.036263496,-0.11462907,0.045290604,0.032772258,-2.0387402e-08,0.051884677,-0.13667424,0.08702558,-0.055061158,0.01186242,0.0029402813,0.10374298,0.07529462,0.022794032,-0.013626517,0.021611504,0.097322434,0.06798257,-0.012289924,0.0040685143,-0.0017905777,0.044880636,0.06617166,-0.04091596,-0.06833407,-0.078775324,-0.03635732,-0.021277983,0.0456918,-0.014546129,-0.018677797,0.0048003136,0.11076679,0.049581066,-0.078489415,0.036961723,-0.028967598,-0.052857727,-0.031606857,0.019466875,0.04739626,0.031774405,-0.018152963,-0.0075200167,-0.009662472,-0.04241509,0.030417113,-0.03238621,0.048467807,0.013718344,-0.010895345,-0.006365495,0.053561762,0.05122214,-0.041339662,0.06045669,0.03957783,0.029144114,-0.055760708,-0.08247204,0.021184716,-0.0029338594,-0.062495694,0.0025476685,-0.09316682,-0.004408286,0.01909993,0.14647733,0.032810614 +3.5.2.6,"A group of enzymes of varying specificity hydrolysing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. The latter were formerly listed as EC 3.5.2.8, cephalosporinase.",384,1.0,-0.007618314,-0.10797032,-0.005693856,0.009596698,0.06320079,-0.0013769307,-0.029241668,0.07566906,0.04538172,-0.08408605,0.025398865,-0.08407176,-0.0253452,0.08538891,-0.07703276,-0.08231525,-0.06376243,0.019418946,-0.067623526,-0.012125643,-0.002177743,0.026332991,0.013065247,0.08381319,0.05529274,0.030514833,0.029976336,-0.007718632,0.016036723,-0.06479885,0.03656873,-0.065111935,0.050274707,-0.02894194,0.045885716,0.059722595,-0.013280846,-0.08609167,0.10908203,0.020749822,0.03429061,-0.060532693,0.022228938,-0.055279773,0.02450623,-0.010020957,-0.015218108,0.05128514,0.010157321,-0.051736098,0.011437028,-0.1686811,-0.040842123,0.05593215,0.014841829,-0.0351496,-0.07484233,-0.06300887,-0.025799038,0.027090665,0.015154529,0.032832384,0.057177596,0.046677593,-0.049674638,0.033257976,0.05472768,-0.10352955,0.055992924,0.00032144744,-0.12265625,-0.064634115,0.022112157,0.113910295,0.064333886,-0.010270042,0.03423174,-0.0385317,0.0019804598,-0.09601848,0.019785631,-0.07851716,-0.094983846,0.03915901,-0.00037144782,-0.09628171,0.04350489,-0.012227489,0.08727166,0.020005658,-0.02101886,0.014285652,-0.029900549,-0.013086481,-0.05761786,0.003687132,0.00031978145,0.05092878,0.00085238396,-0.014835284,-0.08816561,0.059205543,-0.0063786376,-0.039556097,0.009069863,-0.013833173,0.062739074,-0.01976184,0.023174936,-0.046074092,-0.008397534,-0.079442866,-0.011639053,-0.041600604,-0.038402196,0.043439344,0.010957093,-0.039680507,0.03660093,0.026765473,0.028357185,-0.0075191804,0.0212048,-0.031594623,-0.07029888,0.097670086,-0.025097787,2.193028e-33,0.017586172,0.017220635,-0.010435825,0.008172358,0.05375182,-0.0044578677,-0.09459484,0.042053834,-0.03370885,-0.07738798,-0.012278312,0.016315768,-0.0107264705,0.07301563,0.07378698,-0.0016815076,0.04081233,-0.005290512,0.052087937,-0.010728788,0.015684128,0.032327916,-0.05451721,0.005832983,0.08304326,0.0013514353,-0.023729218,0.06433849,0.06945921,0.009211333,0.019363884,-0.035684872,-0.082259096,0.016490826,0.008887927,0.10142511,0.0013683646,-0.05022601,0.03991376,0.06643253,-0.014416749,0.03810739,-0.0025235452,-0.04198947,-0.013063188,0.024267912,-0.08854403,0.042121667,0.055583794,-0.013955562,0.06587387,-0.07454157,0.027108379,0.003569445,0.03975777,0.010663387,-0.06618781,0.062928155,0.044440966,0.038023748,0.010378797,0.08953195,-0.07572354,-0.012590322,0.05373662,0.008694089,-0.018318718,0.02617594,-0.0124993855,-0.04572866,-0.123782925,-0.0015818169,0.022990389,0.044281375,0.039515365,-0.048817188,-0.027796883,-0.016522901,0.0065906895,0.010517398,-0.07213285,-0.03599927,0.003107258,0.02043681,-0.03946109,0.049503773,-0.018110352,0.05435269,0.0028671902,-0.032198705,0.010165799,0.016764587,-0.009389851,0.037062727,-0.07081603,-3.7465334e-33,0.0701507,-0.0580017,-0.056481894,0.005578824,0.018314507,0.018060299,-0.0049758106,-0.0081753405,0.053010747,-0.026550839,0.0408214,-0.0735908,-0.0033823305,-0.08861324,-0.012947859,-0.0007763259,-0.01882875,0.06771485,-0.010705188,0.03034912,0.029551836,0.042513244,-0.03955813,0.053217318,0.061021343,0.025828546,0.030013565,0.068991154,-0.04937375,0.062416285,-0.083418824,0.047431417,0.0014057368,-0.08491066,-0.13003314,0.04195708,-0.022333715,-0.022420844,0.047541384,0.02143461,0.018834163,0.0653725,0.0013230583,0.03549573,0.04005763,0.12980652,0.008482052,0.02231535,2.8693756e-05,0.02080687,0.021771979,-0.01149409,-0.034332305,0.038685,-0.021601403,-0.0040880996,-0.028758133,0.015263122,0.08136147,-0.02599894,0.012659342,-0.009517222,0.03163937,0.021165268,0.011755859,-0.0026495415,-0.13311924,-0.034373805,0.09748228,-0.059990875,0.061406285,-0.118307866,-0.025707169,-0.00073027087,-0.03984315,0.014715135,-0.09645751,-0.04299166,0.007223723,-0.031514425,0.028006256,0.011618803,0.0357355,0.026360612,-0.034504108,-0.026845936,-0.019416241,0.06651733,0.02865864,0.002986939,-0.022656586,-0.022832612,-0.057661943,0.09164809,0.06351579,-3.4449386e-08,0.08995372,-0.04120848,0.017519366,0.0189894,0.07131784,0.061567545,-0.0031166847,0.03478356,0.09060822,-0.02125148,-0.031994063,0.08185869,0.006380781,0.014528178,-0.02326501,0.05082358,-0.0916231,0.007025861,-0.034437183,0.047675647,-0.041713152,-0.004943117,-0.03775138,0.0065710675,0.024118014,-0.072384804,0.02420579,0.09141373,-0.09872222,-0.042835504,-0.006811082,0.07309029,0.014707134,-0.068770885,-0.033655386,0.028313596,-0.09044709,-0.06128479,-0.029590158,0.06667087,-0.00068790663,-0.08796276,-0.06901859,-0.03458549,0.021792827,0.006707699,0.051844068,0.038006756,0.012634755,-0.09555807,0.04722951,-0.03954478,0.0035600131,0.0275884,-0.08228732,0.013236502,-0.061016954,-0.046799485,-0.052792102,-0.112269215,0.031382363,-0.02260354,0.22271968,0.00932039 +3.5.2.11,Also hydrolyses L-lysinamide.,384,1.0,0.007147455,-0.12729973,-0.06429068,-0.008422078,0.06348634,-0.020944333,-0.04429566,0.11050132,0.014571508,-0.035548333,0.050327834,0.04268406,-0.02797198,0.03834391,-0.07702101,0.048660744,-0.026788693,-0.0034895241,-0.01532188,0.035454884,0.039593957,0.034708735,-0.050632603,0.07908222,0.04508766,0.029029593,0.017304827,0.01675025,0.032009937,-0.06704913,0.081875086,0.026620302,0.02771853,-0.10289219,-0.0061595053,0.042329036,-0.09524909,-0.016163066,0.026323296,0.033782,0.013823538,-0.0976001,0.027058642,-0.048501246,-0.023631947,0.002153756,-0.01744593,0.022477025,0.0608422,0.08397731,0.0042201476,-0.07833812,-0.058199447,0.05311378,-0.13011217,-0.07620047,-0.11745549,0.0738759,0.025676746,0.046896115,-0.05301674,0.116736345,-0.012444118,0.05850858,0.02351597,-0.0056194607,-0.0019414079,-0.07224552,0.006775027,0.025174078,0.04459821,-0.10397493,0.099964246,0.04191944,-0.017600702,0.010641746,0.013944526,-0.049508113,0.038087424,0.021442037,0.005040167,0.021268368,-0.037220944,0.082767084,0.04083143,0.0075781313,-0.010997216,0.02782483,0.049755782,-0.10469291,0.03503311,-0.00018540927,-0.014108608,0.021203924,-0.07834871,-0.019113591,-0.0054251077,-0.01925803,-0.064334385,-0.030685583,-0.042090803,0.043929726,-0.05483478,-0.029672798,-0.045467883,0.0006955334,0.057972983,0.022963556,-0.0041263136,-0.08537953,-0.002422702,0.03604481,0.020168811,0.019991715,-0.040460788,0.0012780513,0.072861455,-0.0040362715,-0.019283595,-0.05284868,0.047540076,-0.06328033,0.07081644,-0.021393918,-0.023455016,0.061865356,-0.004301067,2.4464593e-34,0.024681883,0.00043517596,0.022064859,0.0074290005,-0.0018403141,0.0084236,-0.07066636,-0.053351797,-0.007865196,-0.009010847,-0.039592925,0.0006598182,-0.01821426,0.043224957,-0.02430691,-0.0303881,0.047725137,-0.007386616,0.06686192,-0.011766742,0.027438393,0.07260651,-0.010670089,0.050523445,-0.019225493,0.022424517,0.09263982,0.013553222,0.06237855,0.0049926983,0.011611902,-0.0222271,-0.058370594,0.01101559,-0.02148044,0.08335921,-0.09074416,-0.07771062,0.1075154,0.059086673,0.0071965344,0.014191858,0.023300849,-0.022584723,0.047291964,0.018682303,-0.09311737,0.04616814,-0.041044965,-0.019755816,0.056934524,-0.030861212,-0.008210751,-0.021316614,-0.053697832,-0.0005817887,-0.039521437,-0.0070731435,0.010555244,0.09300083,-0.043403752,0.09678782,-0.00671779,-0.015202928,-0.03918809,-0.04697138,-0.0196974,-0.055435993,-0.06487658,-0.044243503,-0.114377156,-0.036877174,0.19935489,0.03668894,0.028925827,-0.047159288,0.023037152,-0.0143674975,-0.0070161996,-0.02218017,0.018560564,-0.094983585,0.013258479,0.10377385,-0.004676327,-0.021493709,-0.04400626,-0.025086902,-0.037290078,-0.02743791,-0.018160446,-0.08648139,0.026345408,0.0064851786,-0.075285755,-1.1257573e-33,0.015624286,-0.11426279,0.08705653,0.021617012,0.022409642,0.011311723,0.081748866,-0.02965028,0.063006945,-0.06340955,0.07756518,0.022292122,-0.08091348,-0.065195985,0.008289119,0.08714467,0.04949931,-0.002576292,-0.05106368,-0.035866573,-0.0007818924,0.06471929,0.0494852,0.00055166526,0.12737243,0.0118396655,0.0140147805,0.009899616,0.018889615,0.050801408,-0.029024752,-0.0033732026,-0.06619636,-0.14093955,-0.043556623,0.05596002,0.0039630868,-0.08211286,-0.041742936,-0.056782085,-0.025051484,-0.031642705,0.07126511,0.024447817,0.035656758,0.05084767,-0.066495635,-0.06792681,0.02890965,0.040503863,-0.014959364,-0.019341117,-0.03537519,0.08006179,0.021767804,-0.0016622115,-0.012025556,0.0036643585,-0.018190866,-0.009248864,0.0024935126,-0.018831303,-0.05177591,-0.010988511,0.01016753,0.03876982,-0.016977035,0.027703822,0.05010912,-0.007353195,0.14559066,-0.016736321,0.06105872,0.09855433,-0.03172306,-0.04515427,-0.05055477,-0.14275531,-0.008871563,-0.03266585,-0.00011717019,-0.034079123,-0.015257422,-0.0059913276,0.032484602,-0.065556794,-0.037918452,0.06659371,0.019247167,0.005883895,0.025614107,-0.036541358,-0.025326034,0.034117214,0.116731234,-1.6704998e-08,0.022024814,-0.096700974,0.040936932,-0.067198984,-0.025666747,0.016610922,0.035006274,0.057298668,-0.0041864347,-0.06088864,0.0008398176,0.090039685,0.0017914114,-0.031263206,-0.0028490305,0.026137322,0.035461288,0.09369802,-0.045190874,-0.01510893,-0.061619576,-0.010380298,-0.0028774044,-0.0005727752,-0.01542177,-0.030979477,0.061313555,0.03978431,0.05214933,-0.021973588,0.034821335,0.004788028,0.07113636,-0.047549,0.008950796,0.07475824,-0.045787264,0.01562997,-0.024284462,0.02850076,-0.046321418,0.013895282,-0.017498167,0.055692647,0.061537374,-0.035401635,-0.011487872,0.05282466,0.01501223,-0.010085824,0.053196948,0.005146602,-0.025565911,-0.035313208,-0.04957126,0.0064628096,-0.029464195,-0.033922642,0.022458231,-0.10248611,-0.028813105,0.0037625327,0.19033182,0.0012323303 +3.5.2.12,The cyclic dimer of 6-aminohexanoate is converted to the linear dimer.,384,0.99999994,0.025982104,0.018106122,-0.079848416,-0.04678655,-0.049500246,0.019359056,-0.07016611,0.090251595,0.05796358,0.025614917,0.0061405636,0.004246309,-0.011883372,-0.018623058,-0.033692434,0.0042951093,-0.116202526,0.07113656,-0.04001832,0.08055523,0.02267394,0.005129723,0.009589372,0.026230019,0.09587471,0.04643262,0.035615157,0.02259502,0.032840353,-0.0065096584,0.0049392846,0.10863384,0.024180632,0.0023394455,0.0034166868,0.03020324,-0.05821879,0.04020185,0.037897684,0.008634203,0.05729053,-0.013487452,0.04976833,-0.07848682,-0.0260827,-0.025830705,-0.027536055,0.073700584,0.043830242,-0.013608783,0.04788276,-0.07147047,-0.056682535,0.06775826,0.025292667,0.070440896,-0.07127865,-0.018369688,-0.007507316,-0.0036492532,-0.010895634,0.026241703,0.016919307,0.03467186,0.03359077,0.010569825,0.008948384,-0.1109071,-0.045927852,-0.039185543,-0.08796041,0.009044577,0.02048637,-0.07677171,0.044800438,-0.031956345,-0.05049554,-0.039694007,0.034937017,-0.025069935,0.0013678559,0.057513393,0.018478362,0.07818755,0.0023610094,0.07695878,0.102982394,-0.005840467,0.04074713,-0.0018965112,-0.027971746,0.03591616,-0.053797126,-0.07732993,-0.15291789,-0.028584281,0.026861731,0.09486075,0.062895544,0.03841547,0.111542776,0.034566864,-0.09922507,-0.07319571,-0.068754226,0.07275669,0.026081897,0.070139125,0.004785155,-0.0023876817,-0.0535375,0.018590597,0.08846576,0.04462849,-0.03001034,0.021487916,-0.02071636,-0.021457491,0.058707945,-0.022641975,0.045674186,0.027978538,0.00468872,0.06826784,-0.02949431,0.036853127,-0.0031873228,-7.6379284e-35,-0.041736115,0.11985779,0.11940774,0.0058046463,-0.020047404,0.023633469,-0.04150296,-0.023971777,0.007329943,-0.022872092,-0.115127675,-0.017043144,0.068997,-0.027797287,0.013081026,-0.031193431,-0.0475783,0.035377853,0.038083088,-0.023971856,-0.024866553,0.088153236,-0.06785619,0.011120517,-0.0137791205,-0.004044332,0.011179224,0.016264053,-0.023830727,-0.01783747,-0.0375899,0.073392816,-0.1086936,-0.03667434,0.035208736,-0.01810992,-0.024992732,0.008903727,0.00976038,0.03368879,0.016937781,-0.0024197488,-0.014667892,0.045375604,0.03656871,0.013599729,0.07597445,0.03889777,0.057813138,-0.050421856,0.0017530585,-0.021300895,0.071929075,-0.052087925,-0.039350376,0.0058230683,-0.015612311,-0.02941209,-0.0061840327,0.09227329,-0.006683205,0.022054907,-0.028639318,-0.00648458,-0.055733483,-0.021227475,-0.033597603,-0.060429677,0.005839069,0.030838124,-0.029988697,0.0013404748,0.11406046,0.093355335,0.042648327,-0.048321705,-0.012209687,-0.08999074,0.01852083,-0.05054228,0.065772556,0.0066165132,0.0580642,-0.08119336,-0.0186125,-0.07203169,-0.007990436,-0.069594815,-0.019469071,0.020135393,0.07591981,-0.14587533,-0.034468196,-0.028720865,0.014904491,-8.650462e-34,0.053887323,-0.031496834,-0.034658916,0.0029713851,-0.054361314,-0.010368396,0.0437944,-0.0045586135,-0.033713635,-0.10096282,0.14786315,-0.0005461607,-0.0071382322,0.004855409,0.06304111,0.026486719,-0.02291083,0.0371378,0.039985713,-0.04400969,0.01302431,-0.034037735,-0.14347729,0.054220255,0.038654897,0.076854564,0.0135056395,0.041611645,0.07052585,0.052525856,-0.050833162,-0.12821135,-0.006707354,-0.0106676705,-0.019568654,0.05093722,0.04955613,-0.088317335,-0.02331695,-0.0052592875,-0.0890105,-0.026944716,0.046192348,-0.021073367,0.05025545,0.01853003,0.00964335,-0.04742532,0.012368478,-0.013383494,0.08869674,-0.014586564,-0.029899143,0.011159095,0.016379947,0.06805,0.029536154,-0.016989026,0.062614225,-0.0285442,0.0058764596,-0.03400625,0.06594086,-0.05842673,-0.04859438,0.02701613,-0.018925609,0.061877597,-0.049795456,-0.0048931837,0.002659819,0.043201447,0.032726288,-0.0461139,-0.04135924,-0.08323847,0.060839273,-0.0042387405,-0.044227876,-0.011031376,0.003694425,-0.025536591,-0.021939298,-0.02655581,-0.09231698,-0.027553579,0.15846874,0.022470767,-0.06402209,0.023889005,0.0025603087,0.02954268,-0.011970159,0.064635456,0.07748712,-2.1329233e-08,0.049464036,-0.0755035,-0.06223266,-0.0782778,0.07518221,-0.0124677215,0.041864403,-0.024453497,-0.015099564,-0.05179885,0.052940246,0.0382383,0.014672635,0.059018206,0.023428071,-0.037587117,-0.05499678,0.0036840064,-0.045130335,-0.04355853,-0.10615646,0.019978737,-0.0970595,-0.07614838,0.056994848,-0.049962368,-0.02482034,0.05925055,0.025134768,-0.0064111874,0.010343024,0.024441823,-0.011773489,-0.053578548,-0.040695682,0.053196263,-0.028155211,-0.04288359,0.02616244,-0.044881262,-0.010090968,-0.047004797,-0.049794886,0.0141312145,0.045987185,-0.044781495,0.038818523,0.018742798,-0.06882755,0.01571781,0.011706143,0.011199544,0.009225827,-0.07057701,-0.0057898755,-0.0765446,-0.06427009,-0.05672653,-0.024305614,-0.014568306,-0.07925109,0.005257456,0.1745581,-0.026894048 +3.5.2.13,"Highly specific; does not hydrolyse other dioxopiperazines, glycylglycine, proteins or barbiturates.",384,1.0,0.024330797,-0.09006678,-0.039830625,-0.031598967,0.0077312333,-0.06693533,0.028623827,0.047719605,-0.019237237,-0.08086937,-0.04624675,0.0533926,-0.025531365,0.08166008,-0.07107513,0.0019450255,0.07485985,-0.03364707,-0.0876499,0.017806025,0.07393536,0.038775902,0.020089462,0.008541251,-0.060248427,0.03857987,0.03574164,0.054077353,0.06725823,-0.05285231,0.03444458,0.03372476,0.032236446,-0.04686184,0.054554284,0.13770665,-0.07298857,0.0154590085,0.113483585,0.035426468,0.06407273,-0.011558515,-0.0045606843,0.007585467,0.02959191,-0.03520828,-0.027380358,-0.022098392,-0.01123292,0.044640508,-0.017327104,-0.06687777,-0.080876954,0.047946885,0.012309176,-0.03461104,-0.08753019,0.000103907005,-0.0035436263,0.02620388,-0.034676537,0.0698347,0.032304227,0.007464121,0.058555093,-0.015531895,0.0052204076,-0.01976083,0.045868818,-0.07907959,-0.03168571,-0.07399608,0.0500846,0.10119642,-0.048635874,-0.038887426,0.0060169273,0.016781984,0.02190093,-0.056807905,-0.02565799,-0.040341925,0.041000586,0.04975654,0.033890694,0.0014714268,-0.06615896,0.028123593,0.0043909554,0.023465384,-0.031822972,-0.030786479,0.07807748,-0.04295435,-0.010117735,-0.005464067,0.016182171,-0.076862775,-0.05534568,-0.0063734637,-0.018449873,0.041087564,-0.017297622,-0.04043059,-0.032385714,0.006246925,0.0088414345,0.054296717,0.0059689577,-0.024063779,-0.08201112,0.010272518,0.08379981,-0.0040961923,-0.0412604,-0.005660862,0.016792273,-0.010000191,-0.036144488,-0.05543894,-0.0125046335,-0.014206858,0.09681296,-0.030242607,-0.04475037,0.08864743,-0.061584614,2.7469125e-33,0.07221182,-0.061242454,0.048919726,0.004208136,-0.046808615,0.06935831,-0.07848983,-0.034264218,0.040094722,-0.028874198,-0.051122203,-0.053315826,0.054934397,0.0761426,-0.013690456,0.05118978,-0.033889093,0.0058793435,0.06378999,0.008568686,0.013301907,0.07518815,-0.06986246,-0.05841916,0.005288164,0.040595498,-0.036330495,-0.01419455,0.02905175,-0.013028857,-0.0781094,-0.08812236,-0.07731497,0.032034464,0.036651347,0.08553384,-0.0874384,-0.039088443,0.04474757,0.039428852,0.053833727,-0.07223669,0.005485493,-0.059032645,0.030670563,-0.009358176,-0.07568232,0.021331437,-0.068573326,-0.012232136,0.031463154,-0.008937286,0.038114212,0.0059320894,-0.06450669,0.017149683,0.039580923,0.055751555,0.047665216,0.08400579,-0.012541249,0.097372204,-0.073259234,0.014924933,0.03161047,0.013439212,-0.11186706,0.037918046,-0.019428076,0.07960696,-0.04948776,-0.0025352289,0.10418691,0.034059167,0.00013895138,-0.095534965,0.029378742,0.028980745,0.02971016,0.097677976,-0.014792996,-0.06069472,0.031374477,0.03896723,-0.124074645,0.06550045,0.09187169,-0.089657545,-0.00092177634,-0.0070043756,0.013208262,-0.089538634,-0.0650978,-0.028428886,-0.044642698,-4.7217713e-33,0.04843119,-0.056849178,0.023020636,0.00587078,0.04189829,-0.027352132,0.015360163,-0.060495947,0.048465397,-0.0384784,0.076106444,0.028256532,-0.03759352,-0.11501335,-0.018258307,0.07471033,-0.036636334,0.02606158,-0.007902206,-0.024216438,-0.004361702,0.038714,0.0019435537,0.05811364,0.049803123,0.027101599,-0.014043427,0.015831338,0.06186838,0.06368407,0.009373106,0.06222747,-0.079981335,-0.09425837,-0.07528985,0.031053534,-0.099534705,-0.081017554,-0.07772813,-0.06422443,-0.013302798,0.038848717,0.009644825,0.06721853,0.025250696,0.1775338,-0.02953695,-0.026959041,0.010470164,0.014291141,0.031449553,0.018710053,-0.031436365,0.10106671,0.054901056,-0.029084075,-0.009679374,-0.011538007,-0.017239183,-0.053946972,-0.018073177,-0.012227977,-0.006548077,0.017606188,0.039878123,0.034964614,-0.026789498,0.035039328,0.017421233,0.006563131,0.10095276,-0.08668485,0.059563596,0.020968953,-0.019307958,0.03369965,-0.058282178,-0.047628086,-0.016449982,-0.017957062,0.03720762,0.04192728,-0.05632046,0.0030293593,0.0509399,-0.0052439207,-0.10333554,0.07002125,0.020177985,0.044506215,-0.0067949463,-0.083991386,-0.09452533,0.011473609,0.05529814,-2.7925113e-08,0.045751836,-0.089582294,0.0043442566,-0.027236467,-0.10362371,0.019037394,0.0022525112,0.027852818,0.041459918,-0.04096368,0.03172026,0.017004479,-0.01982886,-0.022852825,-0.0076688332,0.030705543,-0.009219318,0.05521956,-0.018127553,0.006856738,-0.10835391,-0.025901979,-0.05007623,0.013866936,-0.030882102,-0.052944135,0.009373648,-0.015118658,0.053070046,-0.053365238,0.032511894,0.03007648,0.047699206,-0.08200624,0.040555593,0.059764314,-0.019211546,-0.020200165,-0.011699459,0.02106709,-0.0014139204,-0.04565951,-0.05823005,0.0372093,0.03248514,-0.037410237,-0.036652297,0.079965964,0.040818058,-0.05463451,0.022872208,0.04459968,0.012033392,-0.07554931,-0.07581654,0.039107315,-0.03310311,-0.058814168,0.04095469,-0.10309199,0.013208617,-0.0068803015,0.17836006,-0.004134739 +3.5.2.15,"The enzyme catalyses the ring cleavage of cyanuric acid, an intermediate in the degradation of s-triazide herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is highly specific for cyanuric acid. The product was initially thought to be biuret, but was later shown to be 1-carboxybiuret.",384,0.99999994,-0.041347034,0.022953207,-0.13281992,-0.04275894,0.06990452,0.057263196,0.015000773,0.09520817,0.029276533,-0.041762494,0.023554146,0.042828992,0.036001734,0.013676895,-0.056324508,0.08789226,-0.04218516,0.035427485,0.0061874376,-0.039405465,0.0052269176,0.06632703,-0.026335714,0.00598623,0.037037965,-0.0020581738,-0.014214426,-0.014738557,-0.05946818,-0.04732028,0.03203719,0.037878864,-0.0024642965,-0.01727499,0.06496289,0.006619033,-0.090478145,-0.011205044,0.074963205,0.051559754,0.04435517,0.054329645,-0.064528145,-0.073328674,0.008441002,0.0019260711,-0.015289879,0.011836222,-0.020744223,-0.019443221,0.0009754702,-0.0011508603,-0.016128888,-0.032374263,-0.050684154,-0.060805485,-0.0028329485,0.022306478,-0.11385202,0.015807314,0.072947584,-0.004918426,-0.021282429,0.012546913,-0.000808247,-0.042481937,-0.0069704806,-0.03574222,0.081668384,-0.04722746,-0.031380065,-0.11082521,-0.10035966,0.004836777,0.0006052629,-0.047971975,0.010279496,-0.050827786,-0.024404826,-0.056626916,-0.026986912,-0.06038344,0.03909333,0.026543856,0.08105843,0.008301524,-0.07572805,0.07148522,0.07308259,0.0222161,0.04651616,0.06839826,-0.0035800862,-0.037316304,-0.03258929,0.055564787,-0.029458936,-0.07156933,-0.04198305,0.016393846,0.05280126,0.0066478155,-0.072085544,-0.08959316,0.012271364,0.07397937,0.038938556,0.012009122,0.035839666,-0.056328107,-0.0872837,-0.0681652,0.04459295,-0.03398091,-0.040795244,0.1111036,0.057844624,0.029772174,0.014059042,-0.010330537,0.057668738,-0.027122857,-0.038410828,0.06191474,-0.006170445,0.054791372,-0.10720373,1.44082675e-33,-0.004631914,0.060748473,-0.062322937,0.031742882,-0.077478945,0.03139269,0.005209914,-0.028836768,-0.040131103,-0.088782586,-0.069609,-0.1063978,0.0201649,-0.080505565,-0.066912256,0.0006774526,-0.015047382,0.008133674,0.0491562,-0.032757837,-0.04448914,0.066195875,-0.110262044,0.0033843669,0.027262248,0.04119028,0.005339011,0.010390819,0.0023350373,0.0040929127,0.00510008,0.037489027,-0.09828172,0.011465634,0.029844321,0.0078096287,-0.062275454,0.017494576,0.017250342,0.1063596,-0.021711294,-0.027520848,0.021542864,-0.0028754596,0.062188264,-0.0046228,-0.079461224,0.17859983,0.01617372,0.008875486,0.025833985,-0.039256766,0.05373051,0.06417327,-0.12304323,0.084344774,-0.013238095,-0.015853431,0.046243384,0.015242379,0.043001268,0.018717727,-0.091193244,-0.012942885,-0.015346846,-0.064136125,-0.04916941,0.0017486458,0.0045609004,0.07875693,-0.05651625,-0.0005181091,0.043820962,0.10834094,0.09321803,-0.06330924,-0.032176405,0.018654248,0.07886791,0.061136037,-0.03679373,0.03568605,0.079393655,-0.045092653,-0.065748975,-0.022910325,0.004662711,-0.05040271,0.00859609,0.05549993,0.09997095,-0.075546406,-0.051505003,0.026846062,0.010719707,-1.4745318e-33,0.03332518,-0.04757037,-0.014136135,0.011297156,0.030800162,-0.022480037,-0.004001345,-0.057214975,-0.016613314,0.023006378,0.10291361,-0.05434517,-0.017638147,-0.018123312,0.08240616,0.018878875,0.08074177,0.039118797,0.007148133,0.011967151,-0.027475381,-0.012542373,0.0017101142,0.023755947,-0.07820442,0.031368785,0.0010590673,-0.027090965,0.104175806,0.06973314,-0.04764697,-0.022023246,-0.050778177,-0.016347975,0.03841747,0.11866259,-0.029064324,-0.0058724703,-0.027672047,-0.014741831,-0.026702585,-0.018354975,0.010355375,0.03757366,0.0827549,0.022605704,0.0045000874,0.024984295,-0.07966428,-0.07890707,0.066007935,0.029688578,0.01946283,0.0067199217,0.03583079,0.03435609,0.034859337,-0.025868045,-0.022571236,0.036548153,0.016995765,0.018574309,-0.028352672,0.01088405,0.011122899,0.04202102,0.0022838342,0.10847341,0.0031996078,-0.0052433573,0.027135095,0.054993335,0.033655755,-0.003275932,-0.12033917,-0.047113933,-0.04055868,-0.040595546,0.009712378,-0.07517677,0.014427492,-0.008495968,0.0039459006,-0.017210707,-0.007874488,-0.11047493,-0.025358375,0.11470413,0.034970548,-0.04106559,-0.070657514,-0.010870834,-0.008658016,0.06539239,0.06739569,-3.9547412e-08,0.022896461,-0.064380504,0.0036353434,-0.038692955,-0.0066212667,0.010503906,0.023486508,0.016511312,0.037707664,-0.09442866,-0.03827197,0.05344452,-0.00938543,-0.021260228,0.040862944,0.032158215,-0.015425899,0.07571519,0.010426763,0.013892639,-0.051789325,0.05272455,-0.15608563,-0.09461365,-0.028311282,0.016992938,0.0021237205,0.053809028,0.106532596,-0.05161261,0.066599764,-0.044647433,-0.012082685,0.017873405,-0.014005003,0.0030682734,-0.0040471544,-0.061855,0.057302784,0.010550162,-0.01768889,-0.0008599861,-0.074608184,0.03363506,0.0666147,-0.06564917,0.022862608,-0.041783493,-0.01802232,-0.04199804,0.007062199,0.010008042,0.016617656,-0.01802683,0.028172484,-0.031831622,0.058519457,-0.044862505,-0.037514545,-0.059575163,-0.074460484,0.054429498,0.18050075,0.03664942 +4.1.1.115,This glycyl radical enzyme has been isolate from a number of bacterial species. Skatole contributes to the characteristic smell of animal faeces.,384,0.99999994,0.02809655,-0.07152818,-0.054128777,0.07734482,0.029129026,-0.028048977,-0.05518131,0.00415166,0.049824513,-0.043412548,0.0068883235,0.02685955,0.003762385,0.06763625,-0.0952878,0.014978126,0.016574489,0.022844136,-0.035145357,0.0130430935,0.0064013195,0.03031821,0.06805134,-0.059364516,0.019313574,-0.04761447,0.072903514,-0.028462006,-0.08909023,-0.08574369,0.12840949,-0.006916743,0.04299843,-0.03714312,0.03790836,0.02661359,-0.045499478,-0.025802087,0.074435115,-0.025484454,0.015375053,-0.07299441,-0.002942122,-0.037119128,-0.09610804,0.043012008,-0.012060824,-0.021909555,0.08641264,0.022943955,-0.07365835,-0.08404817,-0.019441249,0.01850023,0.084942706,-0.017142147,-0.013351992,-0.06558382,-0.00010883159,-0.040716343,0.03816327,0.019362107,0.04738391,-0.005576037,-0.10740488,-0.011511406,0.049769815,-0.021144848,0.022691835,-0.030517707,-0.032839477,-0.106807284,-0.015270524,-0.0040476657,-0.032296788,0.039023053,-0.04677451,-0.021601778,0.05129619,-0.037106372,0.038649637,0.00795686,0.059604764,0.059404504,0.0365023,0.048669826,0.045444753,0.0010216848,-0.050585117,0.00977671,0.07049529,-0.0037899443,-0.0028089446,-0.09586907,0.025751248,-0.06971526,0.05386581,0.01105414,-0.0533516,-0.0312526,-0.06851709,-0.028689848,0.027751656,-0.11901873,-0.058613736,-0.025115822,-0.0086610215,-0.021422708,0.022919634,-0.053153906,-0.04752022,0.021674111,-0.049209584,-0.06498304,-0.0028377944,0.050104316,0.13953103,0.0014117741,-0.06471226,0.062487774,0.007252941,0.010435552,0.11083364,0.025858123,-0.0016933614,0.043444496,-0.028567364,-2.778891e-34,-0.008620751,0.049518887,0.0015661207,-0.103795685,0.04884645,-0.09280464,-0.02915478,-0.081437774,0.059149414,0.02818379,-0.010868698,-0.025025377,-0.021421578,0.034273077,0.02637519,0.094296575,-0.03307543,-0.022688773,0.006293291,-0.032643236,-0.008335022,-0.015235864,-0.036065776,-0.044538133,0.006978143,0.003583286,0.001232831,0.0334516,0.09433029,0.020730825,0.063456744,-0.09863999,-0.09056584,0.04428852,0.008954965,0.07275637,-0.06906729,-0.05694845,0.0017597198,-0.026311224,0.017161965,-0.045140788,0.025103562,0.001970874,0.037845403,0.0522524,-0.089643605,0.050075885,0.053885963,0.023016414,0.07443331,-0.021157527,0.049839467,0.042473335,-0.042922992,0.042050432,0.04741712,0.0006189198,0.03966763,0.03421323,-0.014693046,0.088304915,0.03734263,-0.036096085,0.00996655,-0.030561695,-0.100842245,-0.031758975,-0.03849597,0.045701195,-0.007376485,0.01654092,0.07083658,-0.011722679,-0.06422175,-0.045568008,-0.0078205615,0.0006839287,0.00012100055,-0.04289191,-0.098559454,-0.05816331,0.016815573,-0.034722213,-0.062749565,0.057413287,-0.055130143,0.018142296,0.01727104,0.028330477,0.08816942,-0.032920595,-0.080367945,-0.018980702,-0.034122787,-9.230683e-34,0.0839288,-0.041481774,0.044056073,0.05300077,-0.041112714,0.055260375,-0.048139513,0.030304035,-0.008995752,0.006655545,0.034262106,0.024129456,0.048021052,-0.0005282671,0.0885927,0.06494706,0.0821682,0.05361536,0.010168743,-0.0673264,-0.0599673,0.015355423,0.035818513,-0.03891301,0.0049789445,0.047790233,0.03527982,0.0005559739,-0.026774777,0.019138388,0.04920297,0.09742038,-0.005102969,-0.124831,0.06177869,-0.028694332,-0.06271968,-0.044348203,-0.02369706,-0.010971179,-0.02193199,-0.0038494144,0.027776755,0.092475094,0.043338634,0.04571139,-0.017687934,-0.03238146,0.056348506,-0.071194105,0.09882694,0.075494975,0.028587086,-0.008684411,-0.0020111934,0.09017872,0.0332774,-0.024530156,-0.034624573,-0.042048715,-0.07253235,-0.019366387,0.039033853,-0.019316114,0.022439143,0.032126423,-0.010318828,0.005423348,0.038209345,0.0055716354,-0.01847659,-0.018162576,-0.03578244,0.08673703,-0.058175255,0.051669694,-0.07414179,0.034801453,0.046761718,0.035954025,0.04659576,0.005868284,-0.022601156,-0.0833709,0.023005184,-0.13794906,-0.02620948,0.15485296,0.026859537,-0.03778985,-0.027566906,0.03517347,-0.09065263,0.052531764,0.08358331,-2.4919101e-08,0.0040406627,-0.07609077,0.0037366943,0.014576565,0.057715215,0.010682496,-0.033609167,0.012948212,-0.011884924,-0.019036025,-0.104271054,0.09471781,-0.058496997,0.04362831,0.0033304396,0.11265569,-0.04092305,-0.082300246,0.011312587,-0.037683945,-0.07187715,0.033910807,-0.06300958,0.04169873,-0.028130295,-0.002189692,0.036505572,0.05882521,-0.034503914,-0.026438758,0.061513375,0.060797058,-0.10052596,0.04369139,-0.10821012,0.00050340826,-0.0077809133,-0.04539475,0.019251768,0.1018406,-0.03850423,-0.004993616,-0.04145929,-0.00527351,-0.116756596,-0.02719214,0.028474512,-0.029037686,-0.08476044,-0.01148723,-0.041245505,0.06047675,0.00882746,0.04054957,-0.051927008,0.03436158,0.045504294,-0.021326564,0.0005116177,-0.036107216,-0.030449552,-0.025049286,0.09591844,0.06655212 +3.5.2.16,"Succinimide and glutarimide, and sulfur-containing cyclic imides, such as rhodanine, can also act as substrates for the enzyme from Blastobacter sp. A17p-4. The reverse, cyclization, reaction is also catalysed, but much more slowly. It has lower activity towards cyclic ureides, which are the substrates of EC 3.5.2.2, dihydropyrimidinase. ",384,0.99999994,-0.057894666,0.00036740038,-0.073375195,-0.06903332,0.048214,0.039814804,-0.03918982,0.082520425,-0.008117963,0.018124288,-0.010508272,0.0034907297,-0.0028043985,0.08254935,-0.0586952,0.029657746,-0.0418119,0.038852718,-0.0044013704,-0.06039901,-0.001588028,-0.07093031,-0.050364215,-0.0047119455,0.04182788,0.057739474,0.03825049,-0.014230324,-0.046694048,-0.077788144,0.059606984,-0.0504273,0.0099508045,-0.07158985,-0.009600171,0.12744297,-0.10639191,-0.030973116,0.09117197,0.01336345,0.016432917,-0.027997917,-0.015467283,-0.010552867,-0.062258337,0.00542295,0.031842645,0.036017362,0.0057956097,-0.020355955,-0.02248709,-0.0076613748,-0.019756367,0.082682215,0.03370028,-0.03490598,-0.1185095,0.00929219,0.032776352,0.0036907494,-0.007394585,0.025026262,0.03461476,-0.013752869,-0.036871314,-0.032844927,-0.021134792,-0.04541982,0.0016880225,-0.017652811,0.017324759,-0.059946403,0.049583506,0.048595063,0.008375247,0.061301913,-0.008663355,-0.012202844,-0.016034067,-0.03781314,0.040592704,-0.030347217,0.06523808,0.061131943,0.03812143,0.024263442,0.03038259,-0.032254,0.048523992,0.04674329,0.080436096,0.07320897,0.019079976,-0.021374235,-0.046050884,-0.0006026857,-0.06496869,0.048367854,0.015080527,-0.008488177,0.019264735,0.046082694,-0.07087228,-0.08107352,-0.1128682,-0.03998339,0.024654927,0.09032315,-0.039939146,0.011492002,-0.069051616,0.001970569,0.019419316,-0.039484523,-0.097063474,0.082433596,0.039156888,-0.069040455,-0.07646236,-0.06736928,-0.003111384,0.012836581,0.08243255,0.06386526,0.0027685333,0.0755835,-0.15214643,2.5915373e-33,0.04624202,0.032561608,0.02505275,-0.06717134,-0.096069686,0.0023523043,-0.05720851,0.014186078,-0.014369641,-0.07378936,-0.06833705,-0.036643684,0.07751371,-0.04443854,-0.030277494,-0.08124634,-0.002902554,0.04220046,-0.019229593,-0.047097746,0.0042694407,-0.018167559,-0.055541057,-0.019799527,0.041262772,0.0411884,0.017573815,-0.024651464,0.05454477,-0.021616051,-0.010028935,-0.0462646,-0.08849094,0.0057996763,0.04904336,0.021903954,-0.09158993,-0.013352988,-0.038843896,0.07547835,-0.06761118,0.00049452134,0.008980989,-0.06813536,0.09148123,-0.05249732,-0.07476554,0.11625289,-0.018161977,0.033793822,0.07074916,-0.028727753,0.07708092,0.0056531113,-0.008598099,0.05110094,-0.052979864,-0.05867098,0.070931055,0.0457792,0.045836076,0.0865976,-0.062302507,-0.036161322,0.008343158,0.017049098,-0.065512165,-0.01718604,0.007160126,0.11955879,-0.039801322,-0.032597702,0.12058109,0.020914081,0.063515864,-0.022077736,-0.051788658,-0.0027912506,0.05238274,-0.036651548,0.015170449,-0.019994445,0.025200244,0.014085927,-0.030589644,-0.055371165,-0.033428602,-0.06394195,-0.035395335,0.08094041,0.052613847,-0.13892868,-0.0755548,-0.0033617779,-0.021625308,-2.1974882e-33,0.1177921,-0.052146118,-0.0010381357,-0.018941358,-0.011897571,0.03902924,0.09869369,-0.036159027,-0.049172513,0.00030424623,0.057094883,0.0485872,0.058732327,0.010674095,-0.0039020148,-0.005819928,0.04860274,0.026702747,0.036765702,-0.053666368,-0.012098729,0.069093786,0.0027288103,0.0075310254,0.07271832,-0.01765217,0.075252324,0.100200094,0.1828462,0.029000118,-0.035826366,0.037020434,-0.054745853,-0.050901935,0.028676817,0.07342035,-0.030806845,-0.021650027,-0.0022587604,-0.061572872,-0.016705835,-0.008808867,-0.008946455,0.13256644,0.018601773,0.057651192,-0.07405521,0.06852095,0.059681296,-0.036776707,0.011743434,-0.03638448,0.027958585,0.004480991,0.04854509,0.014303535,0.029730305,-0.030999774,-0.036113337,0.017542612,0.010879789,-0.055117898,0.050414167,-0.052559216,0.014231162,0.019049054,-0.031311966,0.042672608,-0.027712977,-0.018378098,0.096084945,-0.03760632,0.024932016,-0.01611834,-0.000542102,-0.043218452,-0.024017934,0.040615615,0.008618782,0.014348417,0.040109817,-0.007084834,-0.0031945326,-0.03263616,0.0073519046,-0.038800605,0.010274101,0.07408133,-0.012354628,0.021539489,-0.039744455,-0.029651051,0.022693802,0.15018313,0.031532157,-4.162949e-08,0.022827845,-0.05248351,0.059141554,-0.038245033,0.014349542,0.11737676,-0.009792807,-0.054523185,-0.015421853,-0.055222344,-0.007261226,0.045419984,0.052521236,0.045541078,0.076393254,0.053597372,-0.031300373,-0.04209413,-0.00014625193,0.03760908,-0.074044146,-0.020827996,-0.13074327,0.0198901,0.018053886,-0.03563997,0.037450757,0.0023126889,-0.07042134,-0.040181085,0.027448047,0.03729903,0.05161251,-0.03633522,-0.029143138,0.05410974,-0.05541326,0.024855813,-0.0031079326,-0.0030297528,-0.03458327,-0.005185877,-0.04326667,0.03073831,-0.027228707,-0.035293628,-0.047241837,0.007963165,-0.06556217,0.026545351,0.002461392,-0.021226354,0.020850025,-0.0612696,0.02475412,0.038324904,0.0060844338,-0.10988381,0.032373667,-0.037613813,-0.00683654,-0.004838618,0.15985273,0.060851265 +3.5.2.17,The reaction is the first stage in the conversion of 5-hydroxyisourate into S-allantoin. This reaction will also occur spontaneously but more slowly.,384,1.0,-0.07892761,-0.080096714,0.009284534,0.027454069,0.08091784,0.016645046,-0.06370324,0.036962617,0.024309805,0.041029934,0.035407577,-0.025639514,-0.013272966,-0.024928788,-0.10253216,-0.0011764016,-0.008279688,-0.050258894,-0.051554475,0.041624874,0.12028656,-0.03334422,-0.061586287,-0.0027433233,0.050136045,0.03377047,0.017978027,0.018022656,0.0042725825,-0.09649866,0.005408056,0.057452288,-0.014076461,-0.039155986,-0.0051115165,0.06824936,-0.013371195,0.011889345,-0.0029436422,-0.058547325,0.086915836,-0.13115914,0.039805543,-0.041708056,0.024726113,-0.057139833,-0.032190364,0.029048614,0.028818598,-0.0012345053,-0.048048135,-0.11410087,-0.10807375,-0.0041926806,0.021332657,-0.00014515284,-0.00045149087,-0.036079396,-0.027578594,-0.02054171,0.010658381,-0.025821464,-0.040853567,-0.0023035305,0.08871341,0.016888294,0.027830279,-0.07907532,0.021123813,0.029107686,-0.006290872,-0.06892724,0.018993054,0.08323094,-0.018135976,-0.022741724,-0.025477625,-0.045641094,0.03852218,0.020716079,0.005962465,0.030631853,0.03397568,0.060225923,-0.03157893,0.022168402,-0.01911776,0.012835461,-0.004684097,0.014743389,-0.022732556,0.034935858,-0.054062508,-0.047886256,0.02584483,0.053285625,-0.009604651,-0.036544796,0.073295884,-0.0328846,0.043411184,0.036469754,-0.070262365,-0.095586285,-0.056307957,-0.008722871,-0.006190237,0.014382971,-0.013404249,0.027997382,-0.0376097,-0.028900249,0.06945842,0.016658999,-0.045299023,0.07673934,0.02088168,0.01983179,-0.050030872,0.0051322146,-0.01913384,0.069441095,-0.00012408585,0.05413419,-0.096522816,-0.008124944,-0.018902088,-1.3752588e-33,0.06785307,-0.042639066,-0.072996035,0.08842556,-0.0856071,-0.015387635,-0.05793747,-0.03071507,-0.01199233,0.007941311,-0.07981534,-0.08327682,0.004052927,-0.002674084,-0.041892987,-0.04084043,-0.0037889725,-0.002861468,0.069509074,-0.09029504,-0.016317075,0.0598045,-0.09078682,-0.0009179718,-0.0687717,0.094812654,0.043756735,-0.051059853,0.031932477,-0.0010095915,-0.03507175,0.03708981,-0.09168597,-0.013849004,0.032343626,0.049033534,0.0073235063,0.039325647,0.05966404,0.071418755,0.08770098,0.015272334,-0.027637336,-0.0013198315,0.09172715,0.02400089,-0.057592914,0.055906933,0.10240719,-0.0014962069,0.05279204,-0.05044694,0.0552626,0.022058802,-0.04318954,0.07700978,0.0022025139,-0.05507809,-0.005044471,0.037344817,0.029295662,0.026510492,0.02179815,0.05881985,-0.03924048,0.04530665,-0.0018351567,-0.06823689,-0.014372895,-0.05334562,0.00049879804,0.025084633,0.09072968,0.027874852,0.09616569,-0.020763174,-0.0014560065,0.046393074,0.04975011,0.027155062,0.0017476085,0.010815453,-0.01956645,0.006340146,-0.02685161,0.03247157,0.007124867,-0.04758471,-0.01099333,0.057267483,0.112223685,-0.12620683,-0.0070637437,0.029636728,0.010696176,-8.733289e-34,0.051982902,-0.13336198,0.023542183,-0.012067929,-0.03659526,0.020238565,0.0038362176,0.03360586,0.03785084,0.0635245,0.12835133,0.02827426,-0.007965716,-0.07325753,-0.020399414,-0.023630196,0.083423264,-0.01544223,0.05309555,8.105937e-05,0.020598976,-0.025504515,0.018064257,0.043546837,0.08212147,0.047219876,0.09664568,0.010368137,0.011080171,0.07797821,-0.01005987,-0.059349168,-0.051535178,-0.04541702,-0.07176547,0.07189267,-0.05733779,-0.02138232,-0.10705423,-0.070418864,0.012204573,-0.00031091258,0.04579057,0.0029306302,0.026413212,-0.0036830902,-0.053575657,-0.011454474,0.023886275,-0.025776366,0.039602257,0.019258352,-0.029448377,-0.027983353,-0.023462225,0.029339379,0.00749471,-0.02955744,-0.01031575,0.0054165814,-0.04297294,-0.024456685,0.037521906,-0.103132315,0.034107313,0.13001536,0.004715457,0.04647422,0.025139095,-0.04902116,0.118229225,0.046799317,0.028937956,0.009309081,0.076481774,-0.10860621,0.026846724,-0.03387173,-0.022397608,-0.14122972,-0.071640074,0.060667492,-0.0380266,-0.07501826,-0.051596347,-0.11353782,0.02011182,0.08646009,0.074918315,0.038236268,-0.013285019,0.029828306,-0.040058337,0.013755906,0.0753012,-3.0043005e-08,0.00080444256,-0.06538662,0.05502743,0.03999707,0.00078669126,0.08332609,0.013262702,0.01925749,0.13650508,-0.10998216,-0.042996254,0.07586639,0.08175834,0.0295653,0.009840833,-0.0061616558,-0.010195487,-0.038978275,-0.0045144483,-0.09057381,-0.06326197,-0.015204474,0.032727692,-0.07094931,-0.0038920306,-0.044687625,0.01696504,0.055350237,-0.034998782,-0.07548628,-0.025264926,0.038029104,-0.036030605,0.02089194,-0.07153529,0.08844622,0.012213012,-0.046330016,0.06614341,-0.08126477,-0.08928745,-0.022618482,-0.030287059,0.0116046965,-0.04600644,-0.0404116,-0.024728158,0.03764211,0.10734761,-0.004232047,-0.0237535,-0.0051400284,-0.020346336,-0.04047352,-0.0024595484,-0.019606318,0.052530754,-0.0673214,0.06757412,0.0026129975,0.031676993,-0.033626746,0.071774386,-0.007784128 +3.5.3.1,Also hydrolyses alpha-N-substituted L-arginines and canavanine.,384,0.99999994,0.006972664,-0.11996419,-0.10325344,-0.027582126,0.0260207,0.07437324,0.0062748017,0.020713547,0.009518765,-0.0031047303,0.011627463,0.09976104,-0.041161757,0.029311204,-0.051933557,0.046348855,-0.02465056,-0.030988945,0.044833004,0.0010180859,0.02706279,0.038029905,-0.04901828,0.005096385,0.041913446,0.02899738,0.005680307,-0.008317911,0.07946199,-0.08604107,0.05421855,-0.0075601307,0.06281264,-0.07758632,-0.032316703,0.01309521,-0.08103219,-0.048632395,0.04732952,0.025196923,-0.0076546133,-0.022092799,-0.02792601,-0.015369353,-0.00945719,-0.024455776,-0.021133626,0.041304547,0.013578107,0.10565867,0.03651843,-0.053603895,0.007363909,0.026360163,-0.05550424,-0.01146939,-0.17351314,0.028588898,0.010981428,0.09811224,0.0030332336,0.08392842,-0.03956389,-0.00066653366,-0.061786037,-0.032062598,0.032493625,0.024982484,0.05779782,0.011013072,-0.020810388,-0.048345115,-0.033712678,-0.0050285785,-0.077247255,0.028328767,0.03436418,-0.014577894,0.0027209346,-0.046052195,0.054242622,0.029987872,-0.004082436,0.15387039,0.0042979005,-0.017564818,-0.067931406,0.06729597,0.08954931,-0.00871041,0.053355593,-0.07480816,0.04350535,0.023931058,0.014977607,-0.010439797,-0.014728071,0.024695052,-0.044978406,-0.013904718,-0.016287772,-0.00489754,-0.050558787,-0.08409217,-0.038013287,0.048393488,0.041469287,-0.033455953,0.06832173,0.0041549727,-0.053995527,-0.016267527,-0.0061351443,-0.028060444,-0.08308322,-0.08911415,0.06643479,-0.017850576,-0.017967869,-0.06342883,0.0037022626,0.009094625,0.087009,0.018751433,-0.043275382,0.058029868,-0.01996544,-1.8891385e-34,0.037783023,0.0076130265,0.029056974,0.030815048,0.0073978053,0.015990729,-0.029204283,-0.017057171,0.043097727,-0.06067681,-0.05100535,0.06451801,0.0096249385,0.024648262,0.02043032,-0.04285578,0.05460888,-0.011216627,0.06244923,-0.0025270588,-0.06935089,0.09933427,-0.060545117,0.046544693,-0.05598551,-0.01145203,0.06145372,0.06477299,0.046398263,-0.0235694,0.009908989,-0.043073893,-0.07196632,0.05186614,-0.032687485,0.025131384,-0.009512295,-0.027935652,0.05450065,0.052390806,-0.012704609,0.025781086,-0.0077699185,-0.028523766,0.006437753,-0.0397469,-0.1054265,0.06945368,-0.051523983,0.026331838,0.008122997,-0.0013575566,-0.024316084,-0.024557251,-0.024672294,0.014689539,-0.0513804,0.07926812,0.03918543,0.049642008,-0.045365702,0.012091271,0.037706714,-0.027340874,-0.055446886,-0.0059286803,-0.029046457,-0.059113603,-0.021047117,-0.009917425,-0.07545777,0.020130996,0.17614055,0.0195919,0.044643693,-0.053555008,-0.025747856,0.042705912,0.025802802,0.024774522,-0.0005098049,-0.024693849,0.06886006,0.098357856,-0.03349236,-0.0120439045,0.03698135,-0.02687383,0.011165062,-0.037845135,-0.024312906,-0.03801143,-0.028161671,0.024324417,-0.002654673,-1.0065187e-33,0.081680894,-0.11596668,0.006202051,-0.0175763,-0.030215912,0.024346478,0.07155419,-0.047771674,-0.007484691,-0.02206913,0.030363709,-0.014282975,-0.064267404,-0.052671764,0.040807787,-0.03863266,0.04195483,0.05481102,-0.026489433,-0.07509871,-0.05075883,0.049057122,-0.034476817,0.019724265,0.023840552,0.0043242876,0.016128367,-0.03379428,0.012557747,0.09083776,-0.0021131039,-0.059961483,-0.04229111,-0.052653126,0.045557864,0.06253296,0.06775522,0.018139113,-0.13147295,-0.090803705,0.0065043443,0.020625757,0.09524839,0.052251145,0.048168655,0.07113712,-0.051034063,-0.053772412,-0.066961735,0.011236055,0.04824989,-0.08928201,-0.009573764,0.039326627,0.007523296,-0.028344322,0.027367722,-0.02454041,0.04405157,-0.01865044,0.015686434,-0.03709399,-0.040083822,-0.059565075,-0.010553846,0.026473124,-0.041531175,0.042946376,0.020154538,-0.047491416,0.07627432,-0.07442146,0.06464862,0.09546173,0.0024518073,0.0058724172,-0.0008160207,-0.1912825,-0.0067354133,-0.11448394,0.013180196,-0.021301068,-0.091399305,0.02535523,-0.048337027,0.01144071,0.02238747,0.07504854,0.026279565,0.08423833,-0.007618642,-0.0136086615,-0.07495334,0.068387635,0.10194615,-2.0790027e-08,0.04474646,-0.06353469,-0.0011715107,0.0016323669,-0.043276634,0.06327178,-0.0041180407,0.044541474,0.057187017,-0.036535777,0.023191264,0.05138414,-0.0046068565,0.055031694,-0.008856711,0.03982838,0.031601913,0.050445143,-0.03884306,0.078129046,-0.11746805,0.08060394,-0.005882864,-0.07347215,0.00032420314,-0.10024516,0.04709293,0.03407838,0.055516362,-0.035749957,0.001974194,0.021996697,0.031893626,-0.09145146,-0.0028541384,0.06424903,0.063810535,-0.053597353,0.0036428396,-0.002932081,-0.07389869,-0.031580012,0.0026944997,0.016874999,0.017763428,-0.06280021,-0.015335977,0.038551208,-0.04171397,-0.013914554,-0.002759681,0.0032255398,0.03754574,-0.11166516,-0.076367244,-0.013654346,-0.02436752,-0.047244933,0.11325549,-0.07865341,-0.020506147,0.002911241,0.15910979,0.035147328 +3.5.3.2,Requires Mn2+.,384,1.0,-0.036360487,-0.044458427,0.017822001,0.02654448,0.022565527,-0.07774763,-0.01671729,-0.0066741058,-0.08113136,0.008605609,0.037501145,-0.00853473,0.038291153,0.046258923,0.035204828,0.017164793,0.008483622,0.0010981181,0.022155419,0.043888234,0.09535097,-0.047738057,0.035636567,-0.10649236,0.080589876,0.038108997,0.021358317,-0.020172775,0.047707476,-0.022710444,0.001964823,0.07182767,0.03759382,-0.07103112,0.027451148,0.03208132,0.02418689,-0.031265844,-0.06567195,-0.0353328,-0.04206804,0.0073473584,0.111062475,-0.0032721923,0.010026853,-0.052635245,0.08713465,-0.06195826,0.032884475,0.050265517,-0.04517185,-0.010509251,-0.038998242,0.06577855,0.007258663,-0.013984565,-0.08798442,0.031221677,-0.020264747,0.020340305,-0.030886542,-0.06213404,-0.027272224,0.036563847,0.08422962,0.0193712,0.016521063,-0.05247887,-0.027940663,0.04684452,0.027259313,0.0340272,-0.06437856,0.02126383,-0.024103496,0.0154093485,0.071803205,-0.052876625,0.09380725,-0.0075167003,-0.11221875,-0.0030692108,0.02679672,-0.006094525,0.10713053,0.07699597,0.012755593,-0.016074155,-0.06754226,-0.0029608328,-0.0026667763,0.034529805,-0.0109483795,0.046426535,0.02924049,0.003930778,-0.03416443,0.031399682,-0.0929341,0.09565302,-0.01218027,0.035898115,-0.07906176,-0.0095144715,0.026446966,-0.07083552,0.06617603,0.040388364,-0.058188744,0.04259121,0.102053724,0.028116403,-0.0054726633,0.00010419161,0.023108644,0.028096316,0.024296738,-0.03508994,-0.00081681664,-0.0015044805,0.0229969,-0.01756427,-0.09027102,-0.007468594,-0.07151089,-0.034110405,0.0024530445,-2.1413545e-33,0.017724067,0.051661883,-0.021066902,0.043503698,-0.01049654,0.04684857,-0.049679115,-0.037014585,-0.004570793,-0.09597654,-0.09281623,-0.053237706,-0.020317584,0.0834843,0.04281833,-0.119611666,0.052882504,-0.017666025,0.14997219,-0.0137100015,0.020340055,0.0016038642,-0.02323011,-0.022663647,-0.013719981,0.07186442,0.13971443,-0.05194357,0.07355635,0.025671242,0.0034975566,-0.08866127,-0.06837138,0.0008731175,0.013852457,0.06542914,-0.11089267,-0.023947844,-0.010690566,-0.025923576,-0.023453522,0.08276505,-0.1598188,0.018604605,0.037131157,-0.077226475,0.0588696,0.04911015,-0.039315026,0.043499716,-0.028326973,0.057479832,-0.01836195,0.0353466,-0.021296928,0.016664,0.08537686,0.019563615,0.07890358,0.08904385,-0.05539112,-0.01854758,0.08613782,0.10673294,0.01158494,0.034094516,-0.04567807,-0.04347245,-0.030515159,0.024576593,0.012338733,-0.10936096,0.076678,0.050040204,-0.021210358,-0.018100826,-0.009838182,-0.05641133,0.025101343,0.02066164,-0.08478535,-0.03234737,0.0024155849,0.023543332,-0.028535549,-0.04999122,0.0005524045,-0.097215496,0.03474627,0.0019069682,0.040347915,-0.023461437,-0.007995815,-0.013179841,-0.066996664,2.4005619e-33,-0.0706518,0.002719601,-0.0036593815,-0.022310164,-0.05268765,0.012721533,-0.013786099,-0.14516166,-0.0033087102,0.04113643,0.04860708,0.026694657,0.0022195794,0.0088315625,0.028081888,-0.017074134,0.0328325,0.00096036313,0.09822324,0.0065470277,0.033520676,0.11440212,0.030622248,0.06478463,-0.02357111,0.10048431,-0.041434612,0.04047153,-0.025466217,0.0045668073,0.008560654,-0.019668229,-0.07769292,-0.060525987,-0.018999357,-0.023958255,0.04581214,-0.003129945,-0.052386582,-0.0062973793,0.05941968,-0.003584158,0.002867577,0.15827869,-0.036884867,-0.07479372,0.06889488,-0.027710633,-0.014873554,0.010659051,-0.02768638,-0.04464195,-0.032866392,-0.08967999,-0.01479311,-0.053243894,-0.0049085473,0.03820727,0.051891975,-0.02260523,0.033034775,-0.06314179,0.0043411446,-0.06140239,0.02199296,-0.009827642,0.053625256,0.020807983,0.008273043,0.06609688,0.03373152,0.09573834,0.13444178,-0.030186828,-0.05156394,-0.009566377,-0.046229932,0.06932179,0.057630423,-0.11416636,-0.031991832,-0.00066542113,0.026452256,-0.044617746,0.06507228,-0.11696032,0.07457187,0.022230344,-0.062330935,0.041871145,-0.031975985,-0.0023272657,0.0017889835,0.0713413,-0.03193887,-1.5502492e-08,-0.0412011,-0.054099,0.012802534,-0.039761156,-0.027760057,0.0279504,0.015556809,-0.014649026,0.063092485,0.053408284,0.07297596,0.011418391,0.016663948,0.0215658,0.047565706,0.0058561373,0.03988123,0.041688845,-0.10159479,-0.06914785,-0.05380872,-7.585195e-05,-0.016357306,0.07188331,0.028453324,0.04774252,0.015446269,0.079720974,0.055502303,0.0042644353,-0.03749378,0.027524283,0.0012584655,-0.04616325,-0.03520016,0.06888794,0.019522034,0.026726296,0.004062684,-0.06453956,-0.11053174,0.067457214,0.019091653,0.015239621,-0.02153527,-0.06587857,-0.072995566,-0.03542341,-0.039272733,-0.04022481,0.027580086,-0.04538773,0.004497423,-0.022909254,-0.016174618,0.05992906,-0.010969464,0.02129064,-0.016883198,0.010401383,0.069140926,-0.015784398,-0.0018027247,-0.06293484 +3.5.3.4,Also hydrolyses (R)-ureidoglycolate to glyoxylate and urea.,384,1.0,-0.041029308,-0.06472276,-0.010892875,0.04520968,0.02536909,0.045983784,-0.019874953,0.0017836469,-0.02653089,-0.019425476,-0.045929566,0.04093277,-0.011421913,0.022741625,-0.07209246,-0.057807785,0.009768795,0.013785678,0.010833307,0.02594732,0.17369638,-0.035782006,-0.08003887,-0.032187518,0.08084608,0.031005595,0.07190357,-0.04474608,0.0049601886,-0.056609306,-0.002772113,-0.051276386,0.009726172,-0.047804266,-0.012426881,0.07081831,-0.058261935,-0.046460573,0.021903021,-0.030877355,0.048753764,-0.010816522,0.0789611,-0.053095784,-0.049328823,-0.010530416,0.0111711975,-0.00060305797,0.015419633,0.009505633,-0.060061745,-0.03331346,-0.059784096,0.020680424,0.014730326,0.0051253275,-0.05537253,0.0069507323,0.023753406,0.026961662,0.0012364307,0.04126506,0.061518926,0.009335889,-0.037865214,-0.04827495,-0.032541893,0.06666667,0.017539578,-0.029119818,-0.022399457,0.046891578,0.010911495,-0.039981596,-0.022735577,0.052578676,-0.031783342,-0.02243275,0.059004895,-0.012367094,0.03935255,0.008365382,0.09340921,0.10816087,0.023550007,0.0075892196,0.030262718,-0.014157482,-0.034414582,-0.09113326,0.06117411,0.01188904,0.029221542,0.031836145,-0.038980097,-0.032435473,0.05497082,-0.036482744,-0.001276694,-0.10358076,-0.06644631,0.02696533,0.03366013,-0.12193523,-0.028885027,0.054351192,-0.017006287,0.077119805,0.118834585,0.008946603,-0.070970036,0.012733426,0.024574663,0.035492443,-0.0797972,0.0094646895,0.0030506458,-0.003267624,-0.08271451,0.0018565735,-0.009965973,-0.0054958686,0.05084674,0.00027917366,-0.07565351,-0.03645471,-0.002003072,8.291871e-34,0.04010018,0.010320622,-0.007482062,0.0009239949,0.026396718,-0.01954564,-0.058631875,-0.021488061,0.026581425,-0.053884808,-0.088563904,0.05710724,-0.04292365,0.05075844,-0.08385601,0.006291122,-0.018374508,-0.021387182,0.07068339,-0.006391869,0.0453938,0.07034054,-0.027575077,-0.0040038032,-0.011360823,-0.032529082,0.031892158,-0.018577427,0.05645184,-0.032322392,0.08273578,-0.07164437,-0.050776634,0.034851883,0.024552327,0.030749314,-0.06312175,-0.058665935,-0.022465592,0.038645495,0.0011873196,-0.035948873,0.03858181,-0.08670327,-0.0067117666,-0.031020174,-0.07496068,0.06736155,-0.007070163,0.08588553,-0.010951014,-0.017183237,0.030051364,-0.0008661021,-0.10542371,-0.05044309,-0.0009144557,-0.00046449152,0.02488047,0.062102318,-0.022645412,0.10848656,0.008205931,-0.04487437,-0.010951288,0.05634128,-0.029030072,0.01757362,-0.007857419,0.02899733,-0.04100401,-0.014054138,0.1374382,0.015501886,-0.028071653,-0.101098895,0.013090219,-0.019887106,0.049436126,0.032459922,0.017965032,-0.03670821,0.01015861,0.009501407,-0.076578885,0.008619378,0.010634751,0.011113232,-0.031264585,0.034547962,0.017665783,-0.069796525,-0.027238622,0.011692181,-0.072110996,-2.2632695e-33,0.15104647,-0.15351193,0.088550344,0.037981883,0.045175042,0.004139392,0.07813404,0.0051240227,0.08016156,0.018982077,0.08119649,-0.00034405978,0.027493203,-0.009501488,-0.031520426,0.0487471,0.06841232,0.039821938,-0.035727087,-0.049138308,-0.06853637,0.03929745,-0.038104586,0.023147007,0.06646279,0.01807577,0.056105554,-0.057873953,-0.009084252,0.03274968,0.034127317,-0.0012628566,-0.08630527,-0.07141595,-0.062011074,0.08088621,-0.021118965,-0.05590839,-0.026180787,-0.018893445,0.009524672,-0.029949255,0.051100556,0.08778671,0.089904435,0.10833492,-0.11818501,-0.0037961786,-0.035976876,0.0041916287,0.008275545,-0.013915737,-0.044614792,0.07216792,-0.0006054762,0.06314107,-0.037157193,0.009789061,-0.0069087027,-0.015070681,0.0050757607,-0.034019206,-0.026800547,-0.0570526,-0.051856656,0.04274006,-0.077328935,-0.029290754,0.057350844,-0.008131303,0.11515133,-0.05387506,0.05164182,0.046302468,0.047914453,-0.0075946157,-0.021152945,-0.06495218,-0.025251,-0.091321856,0.050387245,0.059624434,-0.05331762,-0.033976007,0.03416309,-0.036751065,0.008164993,0.11885638,0.04022019,0.03134686,-0.028235443,-0.034111805,-0.033708118,0.03959752,0.13159199,-2.4245544e-08,0.01655134,-0.06702867,0.06308857,-0.052047502,-0.055701807,0.065045916,0.09717254,0.050759263,-0.009330907,-0.025037585,0.011253075,0.011837097,-0.078690104,-0.06518003,0.016125396,0.027590439,-0.03169609,0.072447225,-0.015881827,0.05031406,-0.07648826,-0.0120234145,-0.08567598,0.05969118,0.022597807,-0.031791955,0.09206919,-0.06041008,-0.10539346,-0.0024770536,0.06554011,0.055549413,0.017395727,-0.03170922,-0.03639065,0.07461383,0.06029011,0.020002842,-0.06386495,-0.065407775,-0.030111607,-0.043698613,0.0180336,-0.028930623,0.02261769,-0.031390734,-0.016680842,0.058560446,-0.004613236,0.00039104448,0.02173449,-0.030457176,-0.045370158,-0.11409065,-0.064134926,0.013982277,0.020726604,-0.08128189,-0.024248816,-0.059891373,0.0057706265,0.018087411,0.18137363,0.009583014 +3.5.3.6,Also acts on canavanine.,384,1.0,0.033553775,-0.06508511,-0.066098005,-0.030089086,-0.049126215,0.07324925,0.07326544,-0.005176593,0.017376171,-0.003626666,0.02487392,0.054403145,-0.028856555,0.11431133,0.0155221755,-0.013249005,0.09050712,0.030048288,0.0057899593,0.030368604,0.010656539,0.022963926,0.082671545,-0.04769127,-0.041307945,0.028552478,-0.03590273,-0.056196738,0.0690237,-0.10179758,0.017135233,0.05059032,-0.06271727,-0.014328038,-0.10577224,0.0224058,-0.046297047,0.065080196,-0.0015020616,0.020863824,0.03558822,-0.0230933,-0.036796175,-0.00068466243,-0.021467097,-0.102232225,-0.05963593,0.0073800855,0.067444056,0.05268694,-0.02166033,-0.044497076,0.03950754,0.0108120255,0.02281105,-0.012670864,-0.06418426,0.021351358,0.0067201606,0.054470714,-0.046661012,0.024347145,-0.011234008,0.015831327,0.0379702,0.022924138,0.0054019224,0.042498138,-0.004426558,-0.07938842,0.017468652,-0.07112142,0.04991865,-0.0067991884,-0.038282786,-0.02721872,0.00869617,0.028893398,-0.06426302,-0.032649625,0.01944845,-0.030214915,-0.043322887,0.039882366,0.034690082,-0.022440808,-0.046672434,-0.010969103,-0.022004148,0.090549886,-0.020531828,-0.043773398,-0.020807575,-0.0074425437,-0.023293965,0.0032929375,-0.058244444,0.0016124395,-0.044362925,0.041487414,-0.044720862,-0.036922712,-0.052652683,-0.013330141,-0.020818114,-0.03401585,0.02684012,-0.10384587,0.025884245,0.022437338,-0.09799984,-0.030163735,0.044554662,0.03491411,0.0043120836,0.022764502,0.06596465,0.0045079906,-0.06953337,-0.06807219,0.054351203,-0.04410124,0.010997378,0.018190024,-0.015607586,0.07009207,-0.022734655,-2.9263846e-33,0.037098993,-0.048544753,0.03717419,-0.0031512843,0.0843481,0.03793281,-0.019188005,-5.8613463e-05,0.05864258,-0.06956705,-0.009439414,-0.06355746,-0.04096757,0.009797941,-0.032997295,0.007700785,0.013867914,-0.0041426574,-0.0062748953,-0.030257039,-0.03778318,0.15064709,-0.102156565,0.028477997,-0.10104867,0.06349052,0.02991861,0.041895397,0.06343186,-0.006480747,0.04634957,-0.0235467,-0.05398346,0.03923755,0.020509683,0.082567714,0.008429098,-0.017629417,-0.026483575,0.02237714,0.013571082,0.045312524,-0.06905191,-0.002249779,-0.058182087,-0.031512186,-0.07449141,0.024062177,0.056361947,0.06770893,0.020167893,0.015468715,0.06914795,-0.059643745,-0.019857012,0.08558195,0.023272213,0.016653476,0.0533295,0.05908605,-0.058641013,0.010673884,0.005356842,-0.03537006,-0.07490983,-0.0024329994,-0.07282609,-0.087044895,-0.022674361,-0.014137508,-0.06832189,0.06864817,0.054220743,-0.022144439,-0.026563004,-0.04899668,-0.02073654,-0.041402556,-0.014439093,-0.006924358,0.001832819,-0.09703026,0.11835966,0.040775005,-0.009648823,-4.4912907e-05,0.006162074,-0.15484545,-0.07893725,-0.015044509,0.0010694425,-0.021866342,0.040565647,-0.024779262,0.002120547,6.4964196e-34,0.0046822717,-0.047756705,0.025233809,0.012902816,0.120580554,0.018348506,-0.059304945,0.023620866,-0.026853982,0.015783612,-0.00979812,-0.039048824,-0.014680624,0.011499904,0.03035503,0.021098603,0.04688014,0.115009844,-0.08811982,-0.005271351,-0.09950747,0.056441266,-0.00094278157,0.08716688,-0.020185728,0.08911479,0.05907243,-0.0022898517,-0.0150842685,0.04082937,0.004013569,0.02432171,-0.14155945,-0.0825445,0.0014277321,0.067537054,0.001046674,-0.027562585,-0.10418528,-0.09942452,0.041629396,0.024158714,0.0529923,0.06854678,0.018546784,0.04688012,0.0036897594,0.010643694,-0.086679906,0.038592447,-0.012332609,0.006295569,-0.010546083,0.039785054,0.05224487,0.046784207,0.08639209,-0.12066043,0.000315644,-0.03861803,0.008334675,0.014040569,-0.081815906,-0.07054641,0.08683737,-0.004695921,-0.023444727,0.035906598,0.045294356,0.002981803,0.05150512,-0.11489609,-0.016270008,0.003165557,-0.10484832,0.011439528,-0.006657473,-0.086485706,0.013780067,-0.08636792,-0.0062458874,-0.06269086,-0.031055208,0.013524894,-0.00090302085,0.05282428,0.027873086,-0.0063636545,-0.038251046,0.124001265,-0.028267825,-0.032284174,-0.06070885,0.045306712,0.046009947,-1.6467947e-08,0.00048735816,-0.07532017,0.004789141,-0.00703063,0.016304046,0.05618629,0.02495782,-0.012938847,0.043425255,0.059588328,0.03440338,0.046276126,0.05842286,0.054295946,0.09588002,-0.007513722,0.08989403,0.019140795,-0.075937465,0.060958758,-0.16030723,-0.00693123,0.07372779,-0.036608417,-0.038107987,-0.05918547,0.009243837,0.08268232,0.09825047,0.018326405,-0.025517393,-0.02090225,-0.041279633,-0.033617523,-0.06482606,0.0021122792,0.12974054,-0.026757272,0.029693654,0.0435592,-0.016635604,-0.021409743,0.009763871,0.09519374,-0.029593384,-0.015079407,0.02167738,-0.014053257,0.011079967,0.00077711,0.017359802,0.06362284,0.040546514,-0.058193136,-0.064290546,0.09407236,-0.036904212,0.017734658,0.0492564,-0.046103146,0.05584307,0.0075369966,0.118178606,0.017204098 +3.5.3.7,"Requires Mn2+. Also acts, very slowly, on 5-guanidinopentanoate and 6-guanidinohexanoate.",384,0.99999994,-0.07417029,-0.13013947,0.020329705,0.03821508,0.03707085,-0.027999585,0.03075314,0.02541961,-0.014824933,0.029213157,0.075591505,-0.05095484,-0.07421565,0.07455034,-0.011610296,0.026189065,-0.039802525,0.0021995294,-0.018427676,0.0073421397,0.062485483,-0.034387443,0.028604697,-0.06765821,0.06192843,0.04259606,-0.014403083,-0.040328316,0.0764166,-0.0928399,-0.035286546,0.04525452,0.017045332,-0.04258719,-0.0109348735,0.1568885,-0.04737607,-0.02456785,-0.046965946,-0.014548378,0.018944044,-0.016075775,0.10228568,-0.028192699,0.0715972,0.0063368175,0.0326395,-0.06217655,0.0205521,0.015701346,-0.077354655,-0.069969945,-0.055199366,0.016057413,0.033129286,-0.018998928,-0.108967714,0.014253824,0.023893543,0.02024283,-0.006738485,-0.034509074,-0.01496712,0.0038127583,0.039001137,0.036830004,0.016703343,-0.07854922,0.034207784,0.03939443,0.05908322,0.038494922,-0.016308038,-0.022530165,-0.08424662,0.02972771,0.024416024,-0.065283746,0.032168098,-0.016530003,-0.038859844,0.013634613,0.041735668,-0.019634992,0.06439933,0.08414312,0.033143785,-0.022429269,-0.03439326,0.028653262,0.070245646,0.09741641,-0.049750946,-0.005372441,-0.0037259075,-0.0017452515,-0.027517706,0.015734233,-0.0637579,0.033020157,0.018661698,0.012487463,-0.051358294,-0.034119546,0.014654507,-0.027286097,0.059562176,-0.019038588,-0.10457909,0.056073777,0.03002576,0.025000896,0.027983755,0.045392092,0.013220815,0.07017407,0.03858823,-0.023973167,-0.03231251,0.03833445,-0.0031916527,0.01767141,-0.06057982,-0.026722543,-0.15119313,0.018924998,0.041008502,3.37365e-33,0.038618416,-0.024114165,-0.05168056,-0.011585259,0.007469538,0.019372154,-0.08958729,-0.034019966,-0.03580103,-0.02524736,-0.057957057,-0.094790794,-0.010625055,0.060452633,-0.018309614,-0.10311935,0.04773021,-0.0012574987,0.0600755,-0.060388673,0.07417602,0.03537645,-0.07111669,-0.0396989,-0.047990885,0.046661265,0.10850047,-0.039272103,0.058017675,0.0060676746,-0.013365378,-0.05574857,-0.045247916,0.0134915905,0.03586662,0.036201652,-0.03888242,-0.0034871078,0.015282209,-0.045476805,-0.020557743,0.06596526,-0.14079975,0.06946466,0.07374569,-0.1063955,-0.003575275,0.07460701,0.013804222,0.045464,0.013447341,-0.0149155175,-0.027216503,0.04210094,-0.025300412,0.0030688916,0.0488452,0.017845776,0.03064209,0.067798726,-0.020204466,0.008805242,0.03963478,-0.004603995,0.018433623,0.075104885,-0.10880893,-0.06959079,-0.004421165,-0.025970764,0.013624334,-0.122556396,0.06755909,0.0400233,0.03533705,-0.062422752,-0.028946333,-0.052189127,0.015056523,0.018571164,-0.049899496,0.001693068,0.012157369,0.038519066,-0.09814084,-0.004111598,-0.016185353,-0.063201465,0.010837731,0.05465765,0.04919208,-0.03784623,-0.01705458,-0.041566104,-0.011623585,-2.4096984e-33,0.048002765,-0.029192042,0.029357024,0.012848702,-0.082890265,0.04869409,-0.014143654,-0.0893224,-0.005965567,-0.002575366,0.095066324,0.02699675,0.008916761,0.006781873,-0.013687763,-0.018519018,0.053416543,0.067325994,0.08479269,0.021854755,0.034947693,0.0809879,-0.011361003,0.09126058,0.048243623,0.10214732,-0.009779273,-0.016860846,-0.024122842,0.022958778,-0.08317261,-0.037304554,-0.11452374,-0.058750834,-0.023736434,0.0023442188,0.026362011,0.013918671,-0.09251124,0.00017209037,-0.00365713,0.019462453,0.041204274,0.13417287,-0.03336276,0.0072900164,0.037957307,-0.011590185,-0.07650789,0.018318694,-0.00339495,-0.022558251,-0.07733438,-0.01604781,0.01281443,-0.011364124,0.035670534,-0.08261058,-0.021182317,-0.021717064,0.04537769,-0.07663968,0.026826112,-0.12797122,0.09664129,0.078441925,0.044231813,0.09874029,0.07292437,-0.047574114,0.025176834,0.05255135,0.12652554,-0.04133431,-0.03580398,-0.058063783,0.04122945,-0.03610844,0.08613958,-0.13413171,0.01734021,0.03786748,-0.03351498,-0.06816493,0.01278726,-0.07837062,0.0657743,0.050527345,0.00648924,0.11536333,-0.033565808,0.023740135,-0.002785454,0.0607937,0.06985027,-2.8998585e-08,-0.00998705,-0.034803674,0.050041854,-0.0270267,0.012027507,0.039935242,0.004702467,0.040775374,0.025045834,-0.0462728,0.0664121,0.060875773,0.033254787,0.009808927,0.061374657,-0.004327677,-0.0018483065,0.06590644,-0.058825307,-0.060089227,-0.048878726,-0.018609794,-0.062380027,-0.01881851,-0.040068183,0.003932081,0.040951535,0.07093003,-0.030464813,-0.0037304868,0.008500551,0.02545664,-0.015000573,-0.006330404,-0.02293814,0.11196762,-0.006055349,-0.01813563,-0.07315422,-0.045303274,-0.11208858,0.05951466,0.009500602,0.030065184,-0.06125521,-0.0629342,-0.036235295,-0.012403677,0.010013717,0.07223963,0.050552428,-0.030082108,0.01983286,-0.02061208,-0.03528207,0.020408576,0.02703093,-0.05008771,-0.03861601,0.0120342355,0.009786351,-0.06232516,0.045142174,-0.034262728 +3.5.3.9,"This enzyme is part of the ureide pathway, which permits certain organisms to recycle the nitrogen in purine compounds. This enzyme, which liberates ammonia from allantoate, is present in plants and bacteria. In plants it is localized in the endoplasmic reticulum. Requires manganese.",384,1.0,-0.044346943,-0.009896237,-0.053189132,-0.019573677,0.04876947,0.0540017,0.05727971,-0.022152452,0.0032731448,0.0082228575,0.00050569355,-0.019978562,-0.034340654,0.009824743,-0.14128037,0.020448543,-0.13035339,0.010181229,-0.0007264082,-0.022958545,0.12562472,0.06536416,-0.05043333,-0.1067653,0.04815187,0.017326329,0.0553395,-0.04582227,0.022439975,-0.11832934,-0.027973104,0.004769798,0.006736195,-0.08128323,0.035104007,0.1453394,-0.0042919368,-0.030885823,-0.03511905,-0.011540399,0.049372923,-0.005759667,0.014104098,-0.030018803,-0.027646802,0.0316427,0.035284735,-0.01453022,-0.0002790768,0.00876993,-0.034571573,-0.048745986,0.03869516,0.06941093,0.060941424,0.033527777,-0.049985815,-0.016230257,-0.07934809,-0.0058043757,0.06353421,0.0115336785,0.007558377,-0.06663484,0.08499187,-0.022109762,-0.036841877,-0.05183512,0.020735463,-0.10839257,0.016669082,-0.07581056,-0.04917576,0.017083857,-0.039558504,0.037109934,-0.012646186,-0.00070334773,0.03236674,-0.009589822,0.045912344,0.067205384,0.09705053,0.012100412,0.073788606,0.03800008,0.016677983,0.0031658304,0.03495325,0.030814726,0.01933177,-0.0063854936,0.009982477,-0.04044254,0.022911133,0.02059169,0.022036694,-0.022885114,0.01985053,-0.024261314,0.008763935,0.09576126,-0.04544714,-0.108993225,-0.08340511,0.011505806,-0.008406429,0.05833153,0.04373596,0.022180382,-0.059886567,0.051521096,0.020903016,0.044457756,0.017581943,0.03924757,0.037742913,-0.06825662,-0.04765872,0.023246605,-0.06661718,0.031727023,-0.04607304,0.09384593,0.019124914,0.02741192,-0.09025311,2.7976194e-34,0.043319356,-0.0016991285,-0.056835752,-0.039855298,0.008373664,-0.009050272,-0.0060563795,-0.030035714,0.04560595,-0.10796017,-0.11982864,-0.072650425,0.0037983546,-0.04638787,-0.028714707,-0.018167246,-0.033537105,0.05547803,0.08813573,-0.021890642,0.042952556,0.05012586,-0.08111194,-0.02739244,-0.022681737,0.034657996,0.09082789,-0.046806782,0.06150015,-0.03308612,0.060655043,-0.05453024,-0.1099708,0.012787922,0.062615745,0.0023797462,-0.05210701,0.06836137,-0.08528773,0.08886527,0.004890844,0.035451047,-0.038471706,0.021884505,0.065468416,-0.09374224,-0.073164254,0.030005282,0.01710095,0.038381115,-0.0107003935,0.016461402,0.08353663,-0.054459818,-0.06235454,0.010471925,0.0025546532,-0.005820578,-0.024371747,0.0068518687,-0.004068027,0.042806365,0.016722105,0.07729802,0.046852708,0.02007775,-0.06314349,-0.0619218,0.044547673,0.11426129,-0.08787619,-0.09045968,0.061762474,-0.010331031,-0.026549775,-0.07517487,-0.119512066,0.0085268235,0.014425842,-0.021861395,-0.007416031,-0.07438249,0.007965688,-0.0077005834,-0.00483187,-0.04006084,-0.018677114,-0.06734008,-0.01555033,-0.041903242,0.14339511,0.00059450953,-0.07717484,-0.016230484,0.015530851,-1.0047189e-33,0.11620303,-0.07225291,0.08552399,-0.028915882,-0.10100697,0.04467459,-0.06462403,-0.006509475,0.040071208,0.03840069,0.04229251,-0.017650884,0.079722434,0.0010359791,0.048122082,-0.01751494,0.04525538,0.049647667,0.04679905,-0.010002976,-0.055146564,0.054398064,0.0020377247,0.018740775,0.010072292,0.016731098,0.001018689,0.025156984,0.08457073,-0.0314275,0.013419772,-0.042950355,-0.064060025,-0.09116264,-0.0057037165,0.00801247,-0.018105809,-0.017734436,-0.021044698,-0.011392394,0.054788347,-0.048227508,0.023362275,0.08204704,-0.028577847,-0.012805527,-0.12844183,0.015631802,-0.0030351742,-0.052596763,0.043687325,-0.0068248874,-0.0033249941,-0.026168386,0.012076292,0.0467608,0.013569003,0.051356215,-0.029884173,0.01989848,-0.0037839604,-0.0053488617,0.022500275,-0.0019685961,0.0012631428,0.031265773,0.019009087,0.057238135,0.0020833313,-0.00878231,0.038825825,0.049393665,0.105579406,0.08967713,-0.008609973,-0.071023285,0.03782135,-0.01766046,0.036407523,-0.12716572,-0.009514105,-0.0037264922,-0.05261471,-0.08419269,0.013863383,-0.061868016,0.05354823,0.09537934,0.017424675,-0.0040927944,0.0070732646,-0.03620227,-0.0968055,0.016345987,0.024625838,-3.2360855e-08,0.019437611,-0.084770754,-0.037762087,-0.023709176,-0.029340629,-0.008353831,0.04355702,0.0876103,0.044845268,-0.039445963,0.035488676,0.059475318,0.021198811,0.014811404,0.08566158,0.0073009217,0.028919257,0.029299656,-0.03733662,0.008911312,-0.05706597,-0.03576445,-0.08127046,0.06288235,0.064762756,0.0012099382,0.067899846,0.083653584,-0.010712423,-0.037015945,0.022772606,0.050739072,0.04753019,-0.012676829,-0.065286845,0.09045921,0.055414148,-0.033379797,-0.03763603,-0.04362375,-0.016064756,0.011258719,-0.0055281837,-0.022195883,-0.017795794,-0.016034113,-0.0345316,0.024862481,0.03399945,0.03787866,-0.02027853,-0.027104054,0.0424755,-0.08666039,-0.06596855,0.048924107,0.03117594,-0.08280749,0.036589377,0.028509313,0.027923582,0.054463964,0.13310744,-0.051012218 +3.5.3.12,"The plant enzyme also catalyses the reactions of EC 2.1.3.3 (ornithine carbamoyltransferase), EC 2.1.3.6 (putrescine carbamoyltransferase) and EC 2.7.2.2 (carbamate kinase), thus functioning as a putrescine synthase, converting agmatine and ornithine into putrescine and citrulline, respectively.",384,1.0,-0.107593276,-0.0014184118,-0.045345426,-0.013120901,0.03909994,0.12368005,-0.12871096,0.048303735,0.06746157,0.0050360477,0.05658432,-0.06987458,-0.010676094,-0.08732504,-0.038618736,0.057108093,-0.08476214,0.07528501,0.0015997445,-0.05152499,0.02035919,0.05269762,-0.012046892,-0.02524428,0.061370924,0.0003156912,-0.018160628,0.013773143,0.010923247,-0.06670399,-0.030780004,-0.06624459,0.00056590943,-0.032666203,0.020032605,0.016861422,-0.039358124,-0.07869422,0.018459743,-0.026535027,0.059289,-0.011394059,-0.0382656,-0.05196737,-0.017223027,-0.027920716,0.06600399,-0.019274235,0.016374478,-0.08576693,-0.02764933,-0.041583415,-0.025464516,-0.051281888,0.00361261,-0.018226638,-0.04818955,0.04348672,0.006362371,0.061066825,0.06741486,-0.049864482,0.013452444,-0.021483617,0.030636305,-0.030082168,-0.03469454,-0.05398954,0.01328483,-0.047598314,-0.06463614,-0.073585324,0.029650943,0.079717256,-0.014265711,0.03900791,-0.08964564,0.08692656,0.04828164,-0.025930615,-0.00908592,-0.037729308,-0.07240017,0.030254908,-0.04757045,0.0049632373,0.015174373,0.14478602,0.04600015,0.0015014462,0.02857303,-0.024369568,-0.027086226,0.0030706313,-0.06004133,0.0908079,-0.0047111018,0.03104575,0.04938198,-0.063073546,0.020827608,0.098068126,-0.053694572,-0.08133842,-0.053553108,0.019892571,-0.018290978,0.043443453,0.02314408,0.0034423315,-0.010772213,-0.03183434,-0.0059976834,0.018164821,-0.088850856,0.12142508,0.03785527,-0.07680489,0.02174075,-0.03422375,0.040007096,-0.04151317,0.0050696437,0.15648553,-0.00703908,0.03099478,-0.11504151,4.1126966e-33,0.031209907,0.059680115,0.049555164,0.013610655,0.019506006,0.023675987,-0.067960314,0.051533226,0.003486738,-0.10892216,-0.08535166,-0.084640436,0.048527624,-0.012783301,-0.039450187,-0.060201757,-0.03741078,-0.058703933,0.0026951656,-0.02501313,0.053782534,-0.0058513544,-0.084782295,0.08992203,0.047463216,0.03355677,0.072819345,-0.06299956,0.03470716,-0.044784438,-0.006819371,-0.061470225,-0.041445836,-0.006773689,0.016666178,-0.043074764,-0.0058175023,-0.012131659,0.03598887,0.11446428,0.034883574,0.037770793,0.023517095,0.015437154,0.07879656,-0.003587178,-0.031457882,0.13954872,0.05175888,0.06767334,0.031757798,-0.048473697,0.092394404,0.046594054,0.0037868079,0.05113221,-0.041783422,0.006402639,0.0048085977,-0.008005299,0.023826754,0.036154278,-0.002500676,0.004666351,-0.032440398,0.050971832,-0.15109003,0.0030535113,0.008582526,0.10214912,-0.04293341,0.0068803704,0.03974136,0.03517972,0.024091672,-0.03634758,-0.112104684,0.042269986,-0.033230506,0.024062427,0.011439203,0.03865032,-0.023041446,-0.045086414,-0.026638635,-0.07076915,-0.06718183,-0.037313152,-0.0003768176,0.02738988,0.09645644,-0.010937709,-0.0521051,0.01754686,-0.009408565,-4.2187522e-33,0.06306191,-0.054891706,0.052666947,-0.004625779,0.020012064,-0.01248319,-0.026548695,0.0101618655,0.08508927,-0.00011620751,-0.010407996,0.03836819,0.102334514,-0.05376355,0.021578599,-0.05471089,0.015402235,0.07680854,-0.035964333,-0.010507471,-0.083603874,0.029133055,-0.036630996,0.014285242,0.044989817,0.058259625,-0.018323734,0.080287695,0.0058113625,0.046745192,0.04197931,-0.043868806,-0.051936742,0.022065146,-0.012498597,0.028082654,0.0108763,0.0036458638,-0.013351608,0.015896868,-0.02337925,0.011942387,-0.029198837,0.07683939,0.008933533,0.036547437,-0.0055309846,0.038245957,-0.049976174,-0.07740604,0.025070949,-0.01697016,-0.0075370027,0.017879438,0.02433065,0.02289763,0.019646723,-0.025957145,-0.0625138,-0.02181605,0.018430194,-0.063907996,0.05789763,0.011144776,-0.018044204,0.046005107,-0.050443392,0.094604336,0.008186493,0.07022732,0.024807531,-0.032492664,-0.021128286,0.031729214,-0.008821485,0.045904808,-0.050641388,-0.04462198,-0.024424313,-0.07100766,-0.067554034,-0.00058740494,-0.030753318,-0.04647458,-0.039471198,0.046445597,-0.005609803,0.14448051,0.015219457,0.03626312,-0.07857445,0.008604888,-0.016671414,0.14424513,0.050499577,-3.8468542e-08,0.011765785,-0.060362127,0.040685836,-0.005197676,0.0026077025,0.02717768,0.0010482122,0.019358704,0.05027359,-0.047191504,-0.08848781,0.023537137,0.004810579,-0.016072148,0.035068676,0.011411098,0.11566428,0.05592115,-0.020849455,0.008123592,-0.06570511,0.0045660245,-0.102654055,0.029454082,-0.022151586,-0.071624294,-0.00097412226,0.08474355,0.032839477,-0.055032164,0.031004865,-0.012808902,0.030238258,-0.04917117,-0.090412274,0.00342134,0.018830908,-0.04773118,0.06732814,-0.046581756,0.05140101,-0.014345516,-0.059389956,0.008924671,-0.015652034,-0.033330474,0.041954894,-0.030089771,-0.005371121,-0.018986396,-0.013267825,0.025244936,-0.0464985,-0.08213681,-0.046469703,0.00029576098,-0.060765352,-0.013909719,0.027804386,-0.034745485,-0.057369716,0.00315317,0.20719449,0.046101168 +3.5.3.14,Also acts slowly on N-amidino-L-glutamate.,384,1.0,-0.0017665799,-0.13140993,0.01614435,0.019110302,0.013660772,-0.012399407,0.01063947,0.026677517,0.04612631,-0.0058089704,0.049335226,-0.0004176611,-0.022578944,0.068331495,0.006074555,0.012033899,0.029891508,-0.0351129,-0.036687855,-0.004097062,0.037252046,0.101645544,0.0035517078,-0.07627849,-0.0020686425,0.043891776,0.053406756,-0.018577322,0.07992473,-0.12897427,-0.01172847,0.06365888,0.03681533,-0.016963197,0.0072611226,0.061208252,-0.07521264,-0.026893241,0.09055586,-0.030521536,0.047187444,0.0097150635,0.044138998,-0.058434587,0.03443477,-0.026396781,-0.0031019098,-0.013417914,0.069366276,-0.028549036,-0.03308166,-0.10338636,-0.01667622,0.025327679,-0.008161233,0.00912593,-0.15472513,0.0016715408,0.027746283,0.04297709,-0.05780621,0.019291691,0.010178453,-0.029886404,0.07558149,0.04481734,0.07604966,-0.08048757,0.025359567,0.005217878,-0.01301691,-0.0037756844,0.054901186,-0.046704132,-0.04680085,-0.074076936,0.04179776,-0.034461565,-0.024126546,-0.08466025,0.05749884,0.049661092,0.036836248,0.0035201749,-0.0081825685,-0.0061283736,0.016550586,0.0067504025,-0.04169607,-0.015629424,0.052764583,0.0020345175,-0.05456317,-0.011330042,-0.035939205,-0.041932072,-0.005784029,0.028285848,-0.07979546,0.016724994,0.008088047,0.12213931,-0.030611616,-0.043536007,-0.043835644,0.03550543,0.075213216,0.012376251,-0.041618038,0.04992954,-0.019812306,0.022120468,-0.04603962,0.029370805,-0.12264218,0.011380775,0.018343555,-0.0047727902,-0.08902035,0.010048239,0.023354413,-0.064501,-0.032511126,-0.04263372,-0.025684733,0.08841186,-0.04176644,-8.672875e-34,0.05174716,-0.07994288,-0.027684355,-0.048412602,0.03906107,-0.023570301,-0.07245862,-0.0031199227,0.06245458,-0.049057174,-0.04385972,-0.07088984,-0.006606803,0.038680628,-0.013918406,-0.053270217,-0.001788807,0.0052621607,0.0071351244,-0.068749234,0.016849868,0.057119183,-0.062397663,-0.048896436,-0.01893376,0.019881506,0.03648891,0.042199425,0.050027557,-0.013228801,-0.007261831,-0.023818318,-0.049378537,0.021046007,0.055300575,0.028633263,0.0024202731,-0.01604052,0.06287957,0.026204826,-0.017593503,0.08800115,-0.09595322,0.0012351538,-0.0064150593,-0.034294948,-0.0770264,0.062290378,-0.019912489,0.10250721,0.093600675,-0.08664198,0.011883026,0.026820635,-0.010434077,0.022228558,0.012444266,-0.02949244,-0.0074300077,0.060250275,0.013753066,-0.031863898,-0.05109804,-0.0010720589,-0.02893768,0.06601383,-0.10416381,-0.06579021,0.021161834,0.03959284,-0.008360308,-0.03311939,0.101900145,0.013215483,-0.0010405321,-0.09528395,-0.015645685,0.018131478,0.007748691,0.044671737,0.058472503,-0.0362582,0.026831739,-0.011364625,-0.022941222,-0.016862793,0.016631134,-0.08545255,-0.036240928,-0.005896213,0.0298317,-0.016972719,-0.021247447,-0.023411337,-0.008027829,-2.0099517e-35,0.10459217,-0.036037967,0.027873442,0.061037824,-0.01885009,0.048409652,-0.029833397,0.017617535,-0.0050013973,-0.015200262,0.07724794,0.023431135,0.008359534,-0.032462385,0.06280657,0.028946996,0.07744591,0.09013952,-0.00048352286,0.0024970644,-0.016540986,0.060485423,0.01056522,0.048304282,0.048180696,0.02722229,-0.01824394,0.042407136,-0.01597141,0.07577121,-0.025253305,0.0043638316,-0.1321181,-0.13814478,0.0019373378,0.0642206,0.003442306,-0.022087846,-0.091707446,-0.059511457,0.047348868,0.07180383,0.13791914,0.052572932,-0.021380669,0.017159898,-0.031661797,-0.054376256,-0.12605767,0.01626059,0.05702975,-0.0024569111,-0.024378458,-0.020405345,0.04908769,0.09691145,0.0017753205,-0.0718581,-0.060263723,-0.025332551,-0.013509922,-0.07064153,-0.032855622,-0.076780796,0.09084301,0.007084825,0.063780785,0.0004205445,0.14137828,0.02402385,0.056106158,-0.001638964,-0.002766332,0.076167114,-0.12171143,-0.01856334,-0.01867966,-0.09808909,0.047191422,-0.091479465,0.028317675,-0.001385663,-0.03099479,-0.101701364,-0.08744299,-0.033884488,-0.0014491872,0.081874505,0.019559674,0.09125138,0.024826162,-0.07888586,0.034668773,0.070822455,0.026025089,-2.0876543e-08,0.045414403,-0.07927933,0.025206275,0.0021321718,0.048764504,0.08227255,-0.012514605,0.030162629,0.054414634,-0.027061941,0.062058263,0.09785226,-0.013923018,0.022254825,0.019139217,0.027425505,-0.0049262396,0.032809284,-0.07800018,-0.010945358,-0.095802926,0.014697861,-0.035916578,-0.021220706,0.015711932,-0.043209657,0.0518094,0.10360454,-0.036542296,-0.06283783,-0.030207278,0.032755688,0.017020699,-0.07766341,-0.057719704,0.0066681704,0.104297586,0.00039002168,-0.018407114,0.052814767,0.009648223,0.0076130517,-0.037531123,0.03057333,-0.067281716,-0.05290737,0.047746893,-0.018287884,-0.021659177,-0.012982521,0.07860181,-0.013110119,-0.011189618,-0.03820414,-0.13046362,0.026601125,-0.03843503,-0.028767657,0.06391072,-0.02736362,0.0024552455,0.003096127,0.069704026,0.05363253 +3.5.3.15,"Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.",384,1.0,-0.03254731,-0.17659529,-0.059713982,0.037593424,0.064747974,0.04821631,0.0009997848,0.003920494,0.07132811,-0.052558314,0.078320645,0.07165758,-0.071234785,0.023007097,-0.008799154,0.08526971,-0.026606612,-0.037144527,0.0115437675,-0.07705573,0.030185416,0.05132868,-0.029458806,-0.023890387,0.027589438,-0.05410162,-0.00694044,0.0075630043,0.0356086,-0.13332684,0.04239654,-0.0010413362,0.012269597,-0.05064092,0.029671172,-5.6230332e-05,-0.06827531,-0.014910438,0.11389988,0.049326137,0.0805103,-0.07254087,-0.041218363,-0.035077166,-0.008711679,-0.012198347,-0.007730677,0.021491908,0.024259584,0.040072214,-0.04839687,-0.05891791,-0.05462935,-0.0021208709,-0.08512444,0.019440826,-0.19779894,-0.026124861,0.031225802,0.041170068,-0.030918455,0.06345998,-0.0011555062,0.03047145,-0.026380787,0.012588154,0.0873568,-0.06887331,0.059517402,0.006998698,0.010245128,-0.053472035,-0.0594825,0.0030049433,-0.019366138,-0.046563596,-0.020359442,-0.08481061,0.009905005,-0.043250795,-0.038439892,0.01158011,0.007323154,0.05322717,0.0030646392,-0.050112493,-0.012994072,0.0012558431,0.004494953,-0.008520386,0.08446487,-0.05774427,-0.02653103,0.060456764,0.017616061,-0.029449591,0.04769303,0.012273343,-0.07849871,-0.0023743745,-0.058072276,0.012088511,-0.039628584,-0.056355864,-0.069438435,0.021624066,0.06736252,0.003911448,-0.03817198,0.008092754,-0.019348193,-0.002100701,0.021127483,-0.0029262654,-0.10442613,0.046788283,0.008390264,-0.032376427,-0.036360044,-0.0056139855,-0.006386573,0.0050003915,0.031120827,0.0663107,-0.030271335,0.12310981,-0.031090202,-1.0074276e-33,0.00015365527,-0.019144723,-0.010393216,0.026063336,0.01661288,-0.0095072845,-0.12782879,0.030401869,0.050859742,-0.037069026,-0.054159917,-0.044458643,0.014743108,0.07863211,-0.018915262,-0.0541761,0.052384064,0.036503535,0.046797354,-0.023006316,-0.02888168,0.103161044,-0.059157033,0.014912637,-0.024372634,-0.029492661,0.0455402,0.036093492,-0.03120459,-0.00511158,0.010014528,-0.047200534,0.0035698933,0.025864076,0.054704178,0.0676241,-0.013073938,-0.017014934,0.041996967,0.029090393,-0.012636039,0.09034193,-0.056467127,-0.0376819,-0.012493927,-0.026721204,-0.11004287,0.09800184,0.008325147,0.071298294,0.098898456,-0.034869913,0.038820088,0.033017345,0.0056629074,0.038823407,-0.06533743,0.018735973,0.048177242,0.020141622,0.015398384,0.0041329837,0.024754344,-0.014744621,-0.009765341,0.04514474,-0.059385512,-0.013622479,-0.009293964,0.03708742,-0.06812894,0.0058640037,0.16244982,0.021819852,0.09924089,-0.034495,-0.06701955,0.044621512,0.044047274,0.006869779,0.0051166625,-0.0359182,0.075253084,0.004764233,-0.021038948,-0.05689732,-0.007935052,-0.04714523,0.066423744,-0.002245226,0.035330202,-0.044954076,-0.06269843,0.015861535,0.021175202,-6.2916696e-34,0.03967887,-0.10647021,0.045194753,0.013575553,-0.057835218,0.056177303,0.0629645,0.021051314,0.041700423,-0.015566952,0.08010051,-0.008126925,-0.040889174,-0.079160124,0.045399893,0.017583163,0.06936106,0.0714537,0.020559363,0.013605038,-0.09252064,0.028553672,0.022868156,0.034770478,0.023171792,0.03479189,-0.046165727,0.0223087,-0.008134054,0.041482646,-0.011227657,-0.054512993,-0.06296556,-0.09391169,-0.017228339,0.10460477,0.017527418,0.05137787,-0.09306231,-0.070327654,0.040272944,-0.03999576,0.082231715,0.06012595,0.028067747,-0.014315317,-0.0078318855,-0.11516397,-0.105315946,-0.051645223,0.033269342,-0.025436873,0.0029227925,0.009254605,0.025454992,0.06330503,0.0347687,-0.053893723,-0.03584252,0.02441524,0.00064963335,-0.032327022,-0.036335126,-0.044591296,0.04865459,-0.037237342,-0.07630845,0.0118171135,0.08776019,-0.017502392,0.09896644,-0.018086461,-0.00548507,0.07376636,-0.06260142,-0.07178306,0.042183887,-0.15179166,-0.03677792,-0.06741873,-0.051637456,-0.049129773,-0.05571377,-0.0380787,-0.12952851,0.058260113,-0.016113602,0.045354206,0.043954242,0.06911037,0.0010370074,-0.0017101585,-0.025180634,0.032798298,0.050997805,-2.438453e-08,0.018212942,-0.022646513,0.10729344,0.013597341,-0.0056268442,0.039137803,0.0247318,0.05263431,0.017465653,-0.06574126,0.042800914,0.1170289,0.042647548,0.004167477,0.051285427,0.011582264,-0.04702897,0.03528411,-0.033739172,0.009429559,-0.09980155,0.04521114,0.009668417,-0.032086942,-0.017617697,-0.10249571,0.047990117,0.06601351,0.0077566262,-0.037948895,0.026130311,0.024400696,-0.00211652,-0.036220122,-0.015541431,0.032439977,0.048962433,-0.039303686,0.000935657,0.07201115,-0.05783957,-0.009092842,-0.019752534,0.016204072,0.028714292,-0.04274478,0.0059750825,-0.03899699,-0.0013532747,0.009858,0.05879455,-0.01743113,-0.023927363,-0.031577285,-0.045253657,-0.014600549,-0.07047046,-0.03208075,0.081379816,-0.039181218,-0.018049328,0.0015855212,0.11248227,0.036264982 +3.5.3.16,"Acts on some other alkylguanidines, but very slowly.",384,1.0,-0.0044450765,-0.09212898,-0.037485566,0.018910186,0.014418736,-0.043283105,0.004153067,0.004263382,0.05135851,0.0073158,0.048709124,0.013571491,-0.038578194,0.16855662,-0.06263362,0.095911205,-0.040827893,-0.050697368,-0.033956274,0.040090308,-0.025537252,0.035205256,0.044222273,0.021593196,-0.03930351,0.03878504,-0.025310379,0.048331276,0.042289373,-0.060749795,-0.03512459,-0.016691767,0.029046893,-0.008992602,0.030376298,0.074935906,-0.030770682,0.020940317,0.06659996,0.09433979,0.07541843,-0.023279449,-0.037427068,0.0033509908,-0.004864179,-0.057483263,-0.026619408,0.0032980188,0.03050459,0.07204561,-0.049694505,-0.09169882,-0.06000958,0.028550684,-0.046077244,-0.04439907,-0.11022636,0.06764979,0.007349441,0.038783617,-0.03185309,0.010236024,0.0008012253,0.009798066,0.0019457912,0.023672288,0.056709427,-0.05933075,0.057829734,0.03443141,0.030855691,-0.035488047,0.0452934,0.10268994,-0.054025825,-0.10801971,0.03967541,-0.10289232,-0.040236514,0.0007801704,-0.06770851,-0.026607715,-0.007162466,0.040353592,0.052409496,0.024273006,-0.026576916,-0.016660621,-0.018819766,0.0502585,0.05742233,0.007838485,-0.004012651,-0.06240091,0.029128881,-0.040826555,0.03402894,0.011137098,-0.080781944,0.030864567,0.015723614,-0.03480565,-0.09185567,-0.05715375,-0.005645945,-0.018318996,0.07292517,-0.055444203,-0.12920636,-0.033225797,-0.035185043,0.027291916,0.012921478,0.042593922,-0.08876114,0.10022679,-0.002431332,-0.00993198,-0.034383997,0.008613681,-0.00028475453,-0.05262142,0.024149194,-3.1263648e-05,-0.03291611,0.08963263,-7.556378e-05,-9.7507385e-34,0.034548443,0.017648617,-0.02849766,0.02024713,-0.026100866,0.0326958,-0.032515544,0.0249518,0.0010860505,-0.024406062,-0.024141485,-0.026055908,0.064112365,0.025307203,-0.016599564,-0.043618217,-0.017963905,0.02616583,0.012451026,-0.0055678366,0.08586982,0.09754688,-0.027830895,-0.005568919,-0.058207422,0.03204896,-0.08398114,-0.031288873,0.03016104,-0.009936525,-0.04660399,0.016588846,-0.10063041,0.02248069,-0.025431877,0.08110709,-0.027888883,-0.045185618,0.06473653,0.00022228232,0.050710693,0.043421164,-0.0697391,0.013635031,0.0360109,0.035011936,-0.0901663,0.08909241,0.0142821595,0.018544082,0.08068383,-0.069599956,0.007984075,0.0014920495,-0.08375716,0.064672254,-0.008376532,-0.09137285,-0.0104275355,0.054692075,0.07575771,-0.016057964,-0.008298154,-0.0061077415,-0.0049669254,-0.016142324,-0.08010872,-0.03291474,0.0041725184,-0.044299792,-0.0281526,-0.03602626,0.073737375,-0.030671392,0.03169039,-0.04843933,-0.034608696,0.011365141,-0.0014780617,0.0010493941,0.044771057,-0.07263744,0.054321516,0.020351795,-0.041946556,0.016593805,0.0055446723,-0.05435825,0.02274787,0.054023083,-0.004423528,-0.07931988,-0.043267287,-0.1036376,0.032373466,-1.173896e-33,0.07511635,-0.114037916,0.05879319,0.0429681,-0.01879549,0.040041182,-0.027858954,0.07206053,0.010574822,-0.015531823,0.06414878,-0.02660166,0.0060956385,-0.0013803066,-0.04234471,0.054049246,0.08123089,0.04279108,0.020606933,-0.06024906,-0.07588637,0.0064853285,0.063350394,0.093614146,0.019280178,0.031970307,0.06757789,-0.042448394,0.0052647814,0.012614766,-0.044303592,0.002678901,-0.12721215,-0.10461082,0.00587993,0.104810014,-0.073450014,-0.007784971,-0.09855221,-0.0611506,0.026261542,-0.027376035,0.0037677537,0.060930625,-0.014076468,0.07738015,-0.009583973,-0.050062314,-0.10564572,-0.031862807,0.04316282,0.010176173,-0.048717022,0.01557831,0.048234317,0.032266337,-0.022882689,-0.12827374,-0.018159961,-0.0018945948,-0.0038355207,0.028083256,-0.05204532,-0.0569447,0.06855066,0.031291112,-0.015878804,0.066952564,0.09551318,-0.011779776,0.08770113,-0.008954704,-0.0013088287,0.010036227,-0.12259175,-0.002167718,-0.024796288,-0.1211239,0.013787191,-0.116788484,-0.014063219,-0.024726737,0.021497985,-0.015906364,-0.049171258,0.008635263,0.010439813,0.032137334,-0.04830189,0.021804001,0.029063534,-0.015393299,0.029378762,0.07469743,0.038406786,-2.059407e-08,0.015359541,-0.009184931,0.06574913,0.047950026,-0.060998164,0.044949383,0.0058965837,0.0798152,0.016998969,-0.06898198,0.008127292,0.07487724,0.10699431,0.04065561,0.014795847,0.054253493,-0.051825248,0.02543955,0.0125331385,-0.037942402,-0.1584756,0.009196059,0.008630592,-0.016726585,-0.057135057,-0.007861092,0.0408972,0.12223286,0.07553755,-0.048441045,-0.005474055,-0.03869408,-0.047867022,-0.00861862,0.042430695,0.05927528,0.0075138165,-0.040930055,0.026085611,-0.0031811213,-0.048700657,0.024718408,-0.056624234,0.051557116,-0.020520495,-0.07366587,0.005653007,-0.010577022,0.048591252,0.02031577,0.12412136,0.024139307,-0.015952345,0.024678124,-0.05211109,0.014445245,-0.047672447,-0.108664006,-0.018771106,-0.00827657,-0.029347248,-0.035820447,0.09036887,0.049706344 +3.5.3.17,"Requires Mn2+. Also acts, more slowly, on taurocyamine and 4-guanidinobutanoate.",384,1.0,0.033666134,-0.12128504,-0.0087461285,0.030483866,0.04305951,-0.02052304,0.018462267,0.06320487,0.011405128,0.035241723,0.00064990966,0.030676166,0.006250431,0.11948371,0.008582005,0.084637955,0.028725255,-0.030243736,0.044879407,0.040659122,0.046081193,-0.033280235,0.013371666,-0.060299736,0.013673539,0.07843678,-0.0036497638,-0.047184125,0.044539075,-0.029598853,-0.020060236,0.046323005,0.044153254,-0.06192281,-0.04510183,0.08551747,-0.07230411,0.025308726,-0.025387919,-0.0003587024,0.056972593,0.036513843,0.0794444,-0.041507103,0.0235401,0.009509452,0.05456161,-0.06190045,0.023853922,0.05385825,-0.042789366,-0.032971974,-0.001081589,0.086349,0.022807656,0.039265785,-0.16402812,0.00034029852,-0.026546614,0.03643735,-0.06789112,-0.008266499,-0.012498541,-0.024143187,0.1042841,0.036593243,0.01586786,-0.02353781,0.050660264,0.06334573,0.05480092,0.04173377,0.032251887,0.0005460871,-0.05071629,-0.004061707,0.013497276,-0.011498448,0.053416014,-0.047485802,-0.08746562,0.017447086,0.030093484,0.032709435,0.113716975,0.06067793,0.028390672,-0.03952838,-0.056158576,0.02729508,0.041146062,0.07636664,-0.060791478,-0.018209947,0.005586705,-0.034728467,-0.015760604,0.011436849,-0.07041131,0.013208928,-0.014994691,0.03023728,-0.05274144,-0.04537824,0.006165388,-0.055969685,0.080217466,-0.025126819,-0.06060215,0.07281823,0.02867594,0.047297884,-0.029198488,0.087109774,0.041130718,0.07708748,0.05890405,-0.041347034,-0.050370913,0.010664065,0.0030771345,-0.0099868085,-0.033096507,-0.060042523,-0.105289906,0.04216387,0.013561117,2.4215995e-33,0.044280965,0.046906017,-0.036223587,-0.008072763,0.016227435,0.07507419,-0.08728854,-0.049404208,0.06622536,-0.029191341,-0.05779369,-0.099309996,0.034840923,0.0697179,0.0052952496,-0.09191491,0.010793528,-0.026363483,0.1406771,-0.06559167,0.03702262,0.032258667,-0.069499135,0.02821385,-0.088460974,0.040931072,0.06548218,-0.028008642,0.0033755223,0.002174541,-0.016849993,-0.0013709089,-0.08033464,-0.02713228,0.008297683,0.048883267,-0.075309604,-0.040231775,-0.00821413,0.0066379616,-0.013051456,0.014024849,-0.10805977,0.05158539,0.025674783,-0.094143696,-0.021055331,-0.0015001415,-0.028336342,0.053517114,0.018162075,-0.022132115,0.03885258,-0.035351805,-0.08705332,-0.0033733575,0.02167361,-0.096262805,0.02634915,0.047387812,-0.008273408,-0.023693427,0.02685127,0.04382842,0.032303266,-0.006871828,-0.07514814,-0.1100923,-0.032532327,-0.027041757,0.035465907,-0.13464515,0.070843585,0.037441593,0.011882702,-0.025948787,-0.054938644,0.00929893,0.04368464,-0.03385403,-0.036706023,-0.042518314,-0.013684219,0.062778056,-0.022471216,-0.008050813,0.03449253,-0.08366183,0.047194026,0.04437595,0.026324626,-0.040780973,-0.053367242,-0.019056022,-0.010604467,-1.8928106e-33,0.037955076,-0.038402416,0.017024362,0.016569177,-0.030732695,0.07537731,-0.0019875409,-0.09021107,0.008842711,-0.03826017,0.1319656,-0.052806847,-0.056067526,0.03707424,-0.017236352,0.00983724,0.027773902,0.040971585,0.06080624,-0.014110383,0.05834051,0.087078,-0.017106801,0.10239659,0.04843475,0.068143725,0.012475133,-0.019818405,0.004445603,0.03232417,-0.06673174,-0.01663374,-0.07992769,-0.11707929,-0.009097496,0.026693387,0.014938486,-0.022007404,-0.0674139,-0.046344694,0.043121267,0.035403397,0.06432214,0.10681539,-0.013342508,-0.04002087,-0.004089993,-0.028322624,-0.082166985,0.02515176,0.032188937,-0.053180426,-0.04983036,-0.056091223,0.016887737,-0.030818688,0.00040274567,-0.09371085,0.008811919,-0.022431446,-0.024997832,0.009294131,-0.0487735,-0.06860379,0.0779061,0.017117282,0.026701348,0.055072457,0.07773689,-0.008333577,0.007257452,0.038787566,0.14675331,0.044660024,-0.04281881,-0.049765203,0.011738397,-0.024656197,0.07252044,-0.15989447,-7.709526e-05,-0.011310724,-0.018264225,-0.07691262,-0.031728968,-0.042168826,0.039334405,0.056958653,-0.027619759,0.07051761,-0.0012508829,-0.027891787,-0.045773506,0.07697051,0.050336577,-2.7223415e-08,-0.019427236,-0.047759857,0.00011513175,-0.015013341,-0.02761879,0.060564697,0.020907462,-0.002679351,0.027382165,-0.08561001,0.05581456,0.08486777,0.05595945,0.011286044,0.01966603,0.038535975,0.0066468087,0.0431459,-0.06405368,-0.038828053,-0.08846236,-0.028483784,-0.05887355,0.015667433,0.026983906,0.01609717,0.0056700706,0.088548906,-0.019931514,-0.027904062,0.06317975,0.01585616,-0.018212784,-0.042744868,-0.037437677,0.07365434,0.06682174,-0.056933895,0.0028295636,-0.020498244,-0.13037975,0.0690228,-0.009685577,0.057439756,-0.0027897975,-0.11070493,-0.04475831,-0.027837694,0.005040932,-0.0028439444,0.016523937,-0.039082166,0.05543664,-0.06880796,-0.04344451,0.0331438,0.0076937038,-0.06549343,-0.02488178,-0.017130332,0.012498683,-0.02861942,0.06595461,-0.015361571 +3.5.3.18,Also acts on Nomega-methyl-L-arginine.,384,1.0,-0.026147695,-0.06552233,-0.08555915,0.01922753,0.046392355,0.032183047,0.032662265,-0.0029084517,0.07325198,0.006013999,0.061398275,0.021303112,-0.04312763,0.061178263,-0.014110732,0.11085621,-0.072549544,-0.057917215,0.043359105,-0.04200798,0.054912146,0.10500081,-0.041630734,-0.08415845,-0.0254381,0.00034591684,0.0005466487,-0.022353036,0.038478192,-0.120607816,0.044836022,0.069770895,0.018136386,-0.012880751,0.04839019,0.021460876,-0.09498811,-0.047503635,0.013772051,0.017367838,0.094625585,-0.0035132705,-0.042025067,-0.04493861,0.002798873,-0.0013084277,0.01593843,0.023459826,0.025489269,0.06262374,-0.021762839,-0.07861531,-0.012061164,0.017570227,-0.037747648,0.006901131,-0.1516609,-0.060512323,0.020180682,0.02014153,-0.026917214,0.027826957,-0.035379913,0.011434373,0.02870766,0.0075988383,0.059953354,-0.076462224,0.022097649,-0.035438802,0.02062765,-0.07173905,-0.0032908856,0.0107374545,-0.032700457,0.008239417,0.011978801,-0.054906312,0.02728038,-0.03176674,-0.043428328,0.062833175,0.07216153,0.039215125,0.03026771,-0.035893135,-0.040565263,0.03537247,0.016372422,0.0026276554,0.045941755,-0.033691566,-0.030329159,0.07449891,-0.017736865,-0.020086344,0.0093555655,-0.0075809387,-0.06953566,-0.012743079,-0.029875396,0.0034522824,-0.06963345,-0.041186556,-0.01261472,0.058540132,0.045291964,-0.013464866,-0.044554494,-0.004913705,-0.009877889,0.031423565,0.02536474,0.0020573258,-0.06783516,0.027959295,0.089038834,0.012475203,-0.06572219,-0.042000744,-0.010733016,-0.06861025,0.0017673575,0.036282413,-0.05819035,0.10446953,-0.064546436,-2.041506e-33,0.04124876,-0.01679114,0.024793414,-0.03299988,0.04845137,0.023472488,-0.032243997,-0.028791089,0.06094634,-0.028741265,-0.042112183,-0.053628482,0.036459584,0.04860428,-0.050558504,0.010622046,-0.0039223447,-0.01427481,0.039359562,-0.04465861,-0.023134327,0.13898897,-0.065269694,-0.02291791,-0.054819062,0.0405321,0.04088617,-0.021545816,0.011488006,-0.03569515,0.028510546,-0.080494314,-0.02108497,0.02845001,0.05332971,0.08424258,-0.01584838,0.016693449,-0.018395834,0.08232724,0.014711467,0.017949183,-0.0827934,-0.046167493,0.019268963,-0.06870642,-0.13108358,0.051427424,0.012599006,0.051301677,0.02905078,-0.028026422,0.036707602,0.019244958,-0.066223964,0.023363028,-0.03575653,-0.032614283,0.015468475,0.020388948,-0.0084526,-0.05957047,0.013775451,-0.01214239,0.043869037,-0.020961525,-0.081316896,-0.063249074,-0.07423131,0.007312358,-0.080515064,0.012821631,0.16118027,-0.009913302,-0.014446595,-0.049481843,-0.092672385,0.039167095,0.023024412,0.056049973,0.04756323,-0.056522194,0.10900188,-0.009505077,-0.02767968,-0.018848868,0.001206243,-0.060274944,-0.0014453413,-0.03350857,0.093688205,0.0023293502,-0.08989744,0.011390549,0.019112352,1.9968977e-34,0.033852395,-0.08264372,0.0701483,0.007972913,-0.0059689954,0.06774166,0.043143075,0.010593305,0.03330492,-0.008038262,0.07956082,0.014732918,-0.02258188,-0.054134514,0.05019819,0.021662448,0.06803151,0.11039577,-0.08386141,0.003927105,-0.07344995,0.06755625,-0.014602797,0.06634876,0.062262338,0.044134036,-0.0021551521,-0.044060525,-0.008021609,0.06776144,0.020967098,0.012293999,-0.06797559,-0.12308577,0.03353574,0.02722917,0.027487116,-0.006918325,-0.104448035,-0.08289283,0.019182922,-0.008004875,0.100165576,0.10123476,0.04326871,0.059959985,-0.03961073,-0.06082527,-0.100554936,-0.02495324,0.024463376,-0.03415544,0.026808154,0.041794803,0.052086327,0.037175875,0.06984755,-0.059928853,-0.018059663,0.0020501635,0.0029533724,-0.040262535,-0.04907477,-0.07315974,0.076770574,0.012319452,-0.0071177525,0.05035428,0.10803024,-0.05034947,0.030842567,0.034656953,-0.026816504,0.0341967,-0.08945696,-0.005986344,-0.028370714,-0.10006963,0.0036655134,-0.09120355,-0.037129406,-0.050515234,-0.017207524,-0.04807826,-0.030630127,0.007898403,-0.0064265043,0.082876004,0.03817633,0.049350176,-0.053006615,0.0030734488,-0.10496239,0.06267056,0.011134654,-2.0541412e-08,0.026002007,-0.10020178,-0.001511149,-0.030421853,-0.071221024,0.05492512,0.055843376,0.040401004,0.041247804,-0.017407052,0.064299986,0.07969423,0.024812521,0.0046955296,0.01963393,-0.0019148889,0.014080556,0.027436752,-0.012101384,-0.045773074,-0.10561763,0.016286112,-0.0028310353,0.025404483,0.0036003145,-0.07106313,0.06461138,0.14669423,0.07518629,-0.07853239,0.03234505,-0.00041596757,0.00978283,-0.037670653,-0.0307053,0.047230914,0.11181525,-0.051165003,0.05397368,0.03912059,-0.06035545,0.053304482,-0.019205147,0.0013153275,-0.04020661,-0.009146856,0.0018732577,0.005988054,0.0013323729,-0.026313446,0.009781751,-0.010031511,-0.012819364,-0.019057993,-0.11881282,0.0013552706,-0.02530553,-0.020117916,0.12352206,-0.052973762,0.024585532,-0.039697718,0.07432992,0.038384043 +3.5.3.20,"Other diguanidinoalkanes with 3 to 10 methylene groups can also act, but more slowly.",384,1.0,0.009378957,-0.15232165,-0.03838435,-0.012815347,0.007903797,0.023146713,-0.065471485,-0.037760664,0.025601834,-0.007559354,0.08927407,-0.04823812,-0.10714973,0.1024733,0.069300644,0.04513899,-0.06526215,0.03277167,-0.055036094,-0.008683842,0.014557142,0.011585509,-0.00046756765,-0.06393146,-0.057847165,-0.03695629,-0.021503855,0.009880561,0.052960783,-0.10141381,-0.03359583,0.08834613,-0.05724589,0.03648754,0.0076335724,0.059622876,-0.10113593,0.03688009,-0.014831718,0.034349322,0.09913561,-0.06449441,0.028660592,-0.062411595,0.018960923,-0.05850062,-0.02842283,-0.009553734,-0.015775317,-0.07292236,-0.039201204,-0.06230543,-0.03239069,0.08247696,0.035453785,-0.076229505,-0.032905445,0.025820471,0.0014050091,-0.023981536,0.055071417,0.036530957,-0.025869103,-0.06473399,-0.0069248294,0.0415613,0.0860523,-0.029088032,0.03738096,0.07022415,-0.004615291,0.015751919,-0.012197035,0.0076803267,-0.060559858,0.00088502147,0.025414264,-0.03484931,0.0022702625,-0.07502378,-0.026699355,0.060147397,0.07407986,-0.0058058454,-0.010703181,-0.00041666054,-0.043587312,0.03298026,-0.07513043,0.019431539,-0.0038988865,0.08786374,0.02573777,-0.046619028,0.016232455,-0.009627964,0.055607066,0.0038837073,-0.040643986,-0.00033472886,0.026775695,0.040500507,-0.12588347,-0.09754379,-0.033781983,0.0143221915,0.0382757,-0.046715014,-0.03815316,0.065280735,-0.030903004,0.023922531,0.05938087,-0.023865353,-0.10157624,-0.026721267,0.0046997913,0.0034006617,-0.037338812,0.03622235,-0.016828936,-0.03239191,-0.02461326,-0.0580211,-0.030776907,0.019496996,-0.039334916,2.3768275e-33,0.10831774,-0.014363686,0.006601773,-0.013859668,0.0314707,-0.03817649,-0.048642874,0.041899,-0.041087694,-0.086628534,-0.07537892,-0.06882017,-0.014022697,0.036164828,-0.078703634,-0.049949765,-0.036099758,0.005988033,-0.030905327,-0.06261189,-0.028788455,0.08014702,-0.07690723,-0.08651535,-0.009431204,-0.013945854,-0.023994299,-0.020052655,0.017951613,-0.014380293,-0.055106536,-0.06003261,-0.09471307,0.043062598,0.006887301,0.06824353,0.012424929,-0.032934252,0.026685113,-0.050701834,0.042556055,0.0050090225,-0.051987566,0.00932883,0.019465275,0.012864854,-0.02502185,0.04945338,-0.06272618,0.064748816,0.019497754,-0.012046697,0.034296416,-0.0315804,0.028379802,-0.060742795,0.036939345,-0.024439508,0.011664565,0.07134655,0.013602676,-0.027341953,-0.077772565,0.022640329,-0.007954502,0.061480135,-0.07913074,0.041550595,0.026324894,-0.077457674,0.032140885,-0.011794322,0.01175871,-0.045963176,0.07611929,-0.058843113,-0.0046400046,-0.057229128,0.018558422,0.044510517,0.072029434,-0.08785883,-0.0039574937,-0.047202736,-0.060070626,0.022514218,0.040457815,-0.032222155,0.00031174076,0.024565691,0.011998102,-0.08377911,0.02422133,0.012474438,0.080608,-3.1862913e-33,0.07501227,-0.033534218,-0.007818152,0.031336766,0.06194499,0.04413803,0.019252805,0.03705671,-0.033023134,-0.037674583,0.10471998,0.016009696,0.079443,-0.040119678,-0.017850805,0.045202654,0.058797643,0.09576785,0.08920756,-0.007372454,-0.061374567,0.040724564,-0.12289911,0.10439762,0.06414307,0.06951409,-0.012602891,-0.0024880352,-0.04051975,0.08251086,0.010161027,-0.045728453,-0.10157141,-0.031629607,-0.0144269345,0.042647764,-0.0155663155,-0.009199739,-0.063315764,0.010650195,-0.020301497,-0.03440149,0.10122136,0.11908037,-0.024033539,0.06452069,-0.020314781,-0.031153226,-0.057390198,-0.004344551,0.090161875,0.031961482,-0.009782987,0.035263065,0.07582166,0.06961051,0.029070858,-0.048594244,-0.06627802,0.0055237114,-0.049094673,-0.032039914,-0.032353353,-0.04976186,0.076301195,0.06571571,-0.05154715,0.07013729,0.074053645,-0.061381508,0.056250755,0.051029876,0.021089938,0.010477791,-0.06963397,-0.09834482,0.0588527,-0.0036469868,-0.024105635,-0.034972683,0.041167825,-0.019938432,-0.0019401051,-0.069534406,-0.09690973,0.024106534,0.062060338,0.009676883,-0.059444916,0.059544344,0.022163782,0.03966009,0.018238485,0.108712964,0.057890024,-2.5319217e-08,0.07776203,-0.042999268,0.10430331,-0.0351671,-0.022741385,0.018978724,0.07588761,0.110143095,0.047049847,0.02335927,0.07979137,-0.005522475,0.107915625,0.055483636,0.10431205,-0.04930775,0.035814784,0.020768005,-0.011885785,-0.023955107,-0.061038826,0.010591994,-0.011597361,-0.043763366,-0.07980789,-0.019823361,0.05022636,0.013787965,0.0049652657,-0.055477574,-0.049455144,-0.010651827,-0.054143026,0.014853956,-0.04308649,0.056509513,-0.0014681155,-0.042364813,0.0028973778,-0.02933084,-0.008953437,-0.00449062,-0.07477892,0.044541072,-0.017138902,-0.09381956,-0.01679169,-0.029310754,0.05920152,-0.02364178,0.064123094,0.06685372,0.0059030126,-0.0063927737,-0.058029663,0.063371815,-0.0031426148,0.034248687,-0.02630918,0.0254831,0.03574048,-0.030647198,0.0784472,0.06519577 +3.5.3.21,"Methylenediurea is hydrolysed and decarboxylated to give an aminated methylurea, which then spontaneously hydrolyses to hydroxymethylurea. The enzyme from Ochrobactrum anthropi also hydrolyses dimethylenetriurea and trimethylenetetraurea as well as ureidoglycolate, which is hydrolysed to urea and glyoxylate, and allantoate, which is hydrolysed to ureidoglycolate, ammonia and carbon dioxide.",384,1.0,0.009809037,0.006705978,-0.040982865,0.03639996,-0.032705523,-0.030766614,-0.019495588,-0.0032590018,-0.025491118,-0.03934894,-0.03250237,-0.059770126,-0.086366974,-0.033640966,-0.09120115,0.032359008,-0.003151047,0.008162003,-0.035080545,0.026747197,0.12150203,0.037841216,-0.09761454,-0.09329159,0.040076304,0.036902808,0.022340614,-0.027918056,0.04921379,-0.065855205,0.050128896,0.010609407,-0.016749287,-0.06366918,0.05138832,0.10482995,-0.0035457464,-0.07625354,0.026521675,0.0019374231,0.09026683,-0.040771883,-0.034392145,-0.072953396,-0.11253959,-0.013354457,0.028146105,-0.005201513,-0.054925054,0.0067222104,-0.07475147,-0.09262024,-0.051984783,0.053386353,0.00075348717,-0.04266361,0.075769566,-0.046775635,-0.07294232,0.016666736,0.019693248,0.046138544,-0.0027594576,-0.0048201885,0.02430922,-0.05680165,0.020173531,-0.050980452,0.028379459,-0.105097495,-0.04655254,-0.029493852,0.020109892,0.04950575,-0.030471072,-0.020163616,0.0027976604,-0.019736249,0.11679073,-0.017420752,-0.021036725,0.0539651,0.08814004,0.015756749,0.08469884,0.04554124,-0.04126852,-0.00616634,0.0758521,0.06049508,-0.014481478,0.07243033,0.008331887,-0.062166583,0.034574926,-0.023934163,0.06549154,-0.057646055,-0.017585265,-0.0013685996,-0.06825301,0.020794783,-0.09672942,-0.10262288,-0.038809534,0.0130581865,0.005501255,0.027417902,0.065778114,0.021436445,-0.12767269,0.002681764,0.04740251,0.035047654,-0.045830768,0.029085144,0.049917515,0.03476026,-0.021321636,-0.07606787,-0.005225257,-0.049717978,0.082126535,-0.014065903,0.00021200777,-0.021249827,-0.02173696,5.231573e-33,0.08402116,0.035978578,-0.052343402,-0.039887305,0.0025119998,-0.0064054015,-0.054103527,0.0152075,0.004242013,-0.06732581,-0.03799522,-0.03937768,-0.05991631,0.10513628,-0.03105896,0.002236241,-0.03811587,0.07651148,0.054539334,-0.064561315,0.06550112,0.0712337,-0.011667809,-4.1534662e-05,-0.0508031,0.011108183,0.024779012,0.006527813,0.021472352,0.002732402,0.06155898,-0.107077435,-0.12043581,-0.055520263,0.029421788,0.0053951642,-0.02576822,-0.0052082813,-0.019006757,0.09522472,0.025289765,-0.012464855,0.06316666,-0.08469138,-0.009292179,0.028198218,-0.09988841,0.031489037,0.025082096,-0.016393619,-0.0024417841,-0.034021426,0.021590522,-0.049919568,-0.11079937,0.0015217443,-0.00020287446,-0.009060313,0.028023193,0.054787982,-0.03642379,0.012419717,0.054075327,-0.024320202,-0.025228111,-0.027439764,-0.03627716,-0.015953753,0.05576984,0.003265464,-0.089448154,-0.05339235,0.071615875,0.042616606,0.030191176,-0.10885082,0.0030151033,-0.03748042,0.10305865,0.0046636895,0.019372977,0.029970758,0.021997765,-0.06972429,-0.03252393,-0.028465675,-0.02980924,-0.004660253,-0.03591668,-0.0002943577,0.0050774105,-0.06282613,-0.0326825,-0.054911684,0.009502285,-7.717463e-33,0.079797775,-0.09128204,-0.0128202,-0.016717799,-0.0025853647,-0.0041871495,0.003921292,0.063524604,-0.0023462237,-0.013693614,0.09885712,0.016537763,0.01986476,0.021035142,-0.008449333,0.013069046,0.09354055,0.013538172,0.020676017,-0.050833486,-0.017689386,0.0012004081,-0.023662323,-0.034070075,0.070826344,-0.014477283,0.008749954,0.003276536,0.058408484,0.0344414,-0.018555908,0.02468266,-0.052132137,-0.07186858,-0.03589668,0.10640951,-0.059095576,-0.07156758,-0.062202882,0.013548084,0.035649344,-0.054376006,-0.028094871,0.09138462,0.037759557,0.045494027,-0.1115596,-0.06187252,0.02011821,0.05895157,0.095427595,-4.1391013e-06,0.014466594,0.08670416,-0.005077307,0.030818047,0.027428104,-0.010140741,-0.048403606,-0.006186061,-0.009354842,0.016716396,0.012489373,-0.030577661,-0.008863502,0.07961757,0.011081361,-0.033037674,0.01525647,-0.04254371,0.10815521,0.008315225,0.055551928,0.007850266,0.021321788,-0.0993407,-0.007181065,0.0032536369,-0.06926803,-0.10750662,0.029044693,0.048556972,-0.009130104,-0.06539067,-0.0037532197,-0.04941654,0.05324288,0.09876309,-0.0147636505,0.063145496,-0.03653093,-0.003553744,-0.07238894,0.12871782,0.08437778,-4.7212062e-08,-0.043462876,-0.10201682,0.02425832,-0.017446548,-0.03361304,0.036961596,-0.0023795024,0.009189454,0.014035339,-0.077646635,0.0073987776,0.080792904,-0.0069174473,0.038055804,0.04563799,0.023653062,-0.04770439,0.042897232,-0.015564252,0.008629349,-0.004042727,0.02507056,-0.075760566,0.024825023,0.043212604,-0.030901274,-0.0032828865,-0.0067157764,-0.013208856,0.023961361,0.045727547,0.14417341,0.039276294,-0.023094492,-0.08231554,0.055257052,0.02417627,-0.068154015,-0.0348864,-0.06353175,0.03443663,0.027198987,-0.047135167,-0.01843214,0.098911956,-0.0021620912,-0.029289266,0.06780152,0.027133657,-0.00634062,0.021610636,0.038780607,0.012784149,-0.027357845,-0.048208967,0.02456404,-0.031232495,-0.10383753,-0.0036355194,0.0136108445,0.035949185,-0.014997711,0.19884226,-0.032113425 +3.5.3.22,"Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It carries out an intermediary reaction between the first reaction of EC 1.14.11.21, clavaminate synthase, and the second and third reactions of that enzyme. Requires Mn2+.",384,1.0,-0.0042947135,-0.025487859,-0.09692729,-0.014223961,0.027334167,0.07334612,-0.05433829,0.03593835,0.050956495,-0.03328906,0.026114414,-0.06680738,0.09292699,-0.033155855,-0.050930295,-0.00461902,-0.06465846,0.020129448,0.05962954,0.02060006,0.07280431,0.08418535,0.00224136,-0.03422796,0.09382737,0.10405336,0.047215577,-0.04920259,-0.005876135,-0.046597626,0.023803383,-0.00043891932,0.06923661,-0.043452214,0.03196401,0.028621962,-0.01637165,-0.046372212,0.107105635,0.04356506,0.005051095,0.05254022,0.01952156,-0.03910807,0.0011958128,-0.01871794,0.028518002,0.0006203897,-0.0068208384,-0.06260686,-0.03213796,-0.097502224,-0.06392129,0.019839047,0.083577245,0.03575178,-0.047085244,0.0114728045,0.054357734,0.003444043,0.04091167,0.013098335,0.038925797,-0.0024486622,0.00952718,-0.06693592,0.012418295,-0.051777672,0.019827317,-0.03200309,-0.015747467,-0.02763334,-0.04672238,0.015548589,-0.02595177,0.072369106,0.08128271,0.002409935,-0.04145932,-0.05603639,0.0095755365,-0.02948137,0.038675264,0.018010939,0.011057925,-0.027753122,0.06461434,0.010878954,0.071905576,0.08620451,0.055474576,-0.00024510507,-0.009984321,-0.0063507897,-0.069110945,0.051270418,-0.06749114,0.010874785,0.05873582,-0.015925914,-0.039132904,0.033808812,0.023741031,-0.017735843,0.017300135,-0.018043134,0.031303406,0.07032287,-0.011752474,-0.022024728,0.07761008,0.002192156,0.015805785,0.024239035,0.05079288,0.05821787,0.11862666,-0.03897861,-0.013008957,0.00015654071,0.020451378,0.009414768,-0.01300045,0.010949986,-0.06858519,0.06918202,-0.097690076,1.0511627e-33,0.017527027,0.008190239,0.016551994,-0.05238481,0.054024108,-0.03088528,-0.07358177,-0.022882197,0.031271294,-0.054581326,-0.06993411,-0.086630695,-0.005159283,0.04057015,0.020367337,-0.042587016,0.027051255,0.010031641,0.066238806,-0.030474536,-0.02291436,-0.0017820253,-0.036423795,-0.017911792,0.022339784,0.04657221,0.058675397,0.028706372,0.11987042,-0.036867056,0.026240908,-0.08704475,-0.09168143,0.022168508,0.06708132,-0.0471315,0.004936669,-0.028028538,0.00921306,0.030956367,-0.044808462,-0.0039271843,-0.10246139,0.00802227,0.06989758,-0.08364909,-0.048002444,0.061021898,0.03662852,0.07286449,-0.022777786,0.019025963,0.0954824,0.029023131,-0.049065262,0.034144577,0.012532958,0.002422436,0.06256141,0.026523586,-0.011289825,0.037929397,0.0051908344,0.010619993,0.068449944,0.021682676,-0.0621999,-0.11795507,-0.005069945,-0.03663995,-0.053656165,-0.08586833,0.012713506,-0.012265168,0.030209292,-0.06720112,-0.118803464,-0.056402665,0.012972303,0.014463384,-0.054999303,0.048102915,0.010839692,-0.07537473,-0.006616737,0.030118808,-0.09195502,-0.04903808,-0.020382354,0.03297366,-0.004513457,0.013248543,-0.071166016,0.07236876,0.02038659,-1.436345e-33,0.08960378,-0.090832435,0.09626849,-0.06601715,-0.11045226,0.051309466,-0.09461454,-0.0836741,-0.025064856,-0.03436945,0.012344909,-0.033215974,0.026711598,-0.04959632,-0.038094714,-0.04735219,0.029897623,0.13180636,-0.08140931,0.007995321,0.044843998,0.104006365,0.048232347,0.049358096,0.016264115,-0.02341742,0.049492165,0.0685513,-0.016058523,0.0634452,0.015091794,-0.036946576,-0.04948689,-0.052840423,-0.08879364,0.017164545,-0.0006011409,0.025527874,0.07677403,0.030380728,0.037267413,0.0116373375,0.010625096,0.055536725,-0.0026372392,0.012457811,-0.007947804,0.026694024,0.009483012,-0.05729929,-0.020223591,0.047010165,-0.0060309973,-0.01749132,0.023423024,-0.01229406,-0.022682995,0.00782964,0.07793754,-0.09303832,-0.025892245,-0.064707555,0.05229482,-0.042965688,0.12060478,0.047966223,0.019484954,0.11588548,0.1006754,-0.08586557,0.0014097398,-0.023036622,-0.043687258,0.06823603,-0.005975792,-0.0014645482,-0.07167693,-0.070327766,0.054576084,-0.036171548,0.011774224,-0.016526606,0.03384819,-0.08241811,-0.03403343,-0.07634689,0.010823468,0.06394373,-0.037191413,0.041722428,-0.017827416,-0.064575754,0.010267609,0.08576222,0.03345717,-3.5494832e-08,-0.0019852275,-0.07604813,0.039443675,0.010042702,0.03645364,0.005266034,-0.08230403,-0.043973926,0.057638835,-0.0063474174,-0.06921762,0.019485146,0.008808842,0.060545333,-0.026035435,0.050924234,0.01040984,0.019829484,-0.014160663,-0.013681556,-0.03724556,-0.061460964,-0.08276335,0.103010654,0.113582194,-0.09430952,-0.03481006,0.09008763,-0.0014241361,0.016634442,0.0020098,0.023449216,0.0011842769,-0.03703735,-0.006452568,-0.0025153814,0.0023618028,-0.041990656,0.027912257,0.022061769,0.01096534,-0.02238004,-0.0055569876,0.0123892715,-0.10224229,0.047536977,-0.00017832896,0.035589192,-0.104558334,-0.08102706,0.09833959,-0.05900654,0.025361866,-0.015116152,-0.09656798,0.06879577,0.023252986,-0.06935669,-0.047802072,0.021172227,-0.010725762,0.012756412,0.117004275,-0.08252442 +3.5.4.1,Also acts on 5-methylcytosine.,384,1.0,-0.00054504984,-0.0298295,-0.0064417566,0.030619262,0.0539415,-0.021923732,0.026932575,0.010046505,0.03444017,0.022164548,0.0108574275,0.044616196,-0.0253939,0.05983053,-0.02167061,0.123634435,-0.066241935,0.0063455296,-0.03953974,-0.037067585,0.028962178,0.025215583,0.00035880666,-0.031763878,-0.061512407,0.014381132,0.016766759,0.028966403,0.0005715684,-0.05542868,-0.037923742,0.0933613,-0.040245462,0.00953846,-0.023149224,0.06685224,-0.05207636,0.023380894,0.004982722,0.028653122,0.096869074,-0.05525002,-0.027329748,-0.031731326,-0.043908603,-0.020969307,-0.011011001,0.0062550358,0.060231216,0.035622373,-0.030205723,-0.087268144,0.0016660036,0.031699117,-0.048370324,0.012993722,-0.107233256,0.011935278,0.029796183,-0.028608158,-0.037267786,-0.014232545,-0.04087424,0.047801632,0.038500667,0.035063162,0.029134408,-0.06865278,-0.03196969,-0.012765498,0.0071005095,-0.076334774,0.031540528,0.039475434,-0.022625068,-0.0013383122,0.005370348,-0.09091914,0.027146416,-0.030524751,-0.069905795,0.05007901,0.06114401,0.021647643,0.051579088,0.0067431023,-0.03692153,0.026708506,-0.02129812,0.038552646,0.013947923,-0.03555492,-0.010447396,0.027251825,-0.09328226,-0.034595,0.00066164375,-0.017483165,-0.035849433,-0.003081547,-0.026307477,0.03058957,-0.08434017,-0.017117089,-0.00645769,0.01610057,0.048796214,0.005069719,-0.08770297,-0.030719837,-0.041462414,0.045564957,0.014242616,0.02099078,-0.03209493,0.04848002,0.07828112,0.051116098,-0.03947477,-0.06623594,-0.0054657995,-0.024982076,0.0037325425,-0.027574034,-0.11321547,0.009718783,-0.051741224,-2.197462e-33,0.02010964,-0.025600305,0.05772446,0.028522575,0.042042248,0.054668188,0.0082407445,-0.013587625,0.07475033,-0.04355568,-0.037130844,-0.075302765,0.0877837,0.030839702,-0.047285955,0.011062804,-0.0410323,-0.011407138,0.012966351,-0.073701605,-0.021023108,0.08086801,-0.07194886,-0.055020817,-0.080008656,0.077205464,0.0074032224,0.032577403,0.060871053,-0.008147792,-0.0483697,-0.0056975,-0.02167618,-0.0024120111,0.026124593,0.19546771,0.016333092,0.060417052,0.018216094,0.067264125,0.041903634,-0.022720385,-0.07642138,0.012994256,0.0050396877,-0.03791205,-0.12944533,0.025837421,-0.0050997185,0.016765947,0.046747524,-0.05404346,0.07934314,-0.026641004,-0.07155053,0.016538266,-0.012892594,-0.08387682,-0.040259827,0.08836918,0.005759404,-0.046278264,-0.0061141513,0.022011425,-0.021610714,0.00726365,-0.073340066,-0.09591187,-0.06463792,0.008035885,-0.024282848,0.04777321,0.19526279,0.02712643,-0.02025389,-0.007461602,-0.03706154,-0.032598,0.010723152,0.07610382,0.037752245,-0.11639195,0.0740267,-0.013120152,-0.024298498,0.006821026,-0.01847318,-0.10550997,-0.011604569,-0.0068406323,0.09666171,-0.10883698,-0.0168831,-0.012645639,-0.034965187,-3.9108844e-34,-0.0030159904,-0.05572868,0.061062522,8.01141e-05,0.012719377,0.022538038,0.039396398,-0.018336141,-0.07072525,-0.027560495,0.108199395,0.013829921,-0.055442248,0.047317713,-0.0107441135,0.05488956,0.020050464,0.06894793,-0.012851312,0.032648664,-0.019720053,0.05672979,-0.02651419,0.13414142,0.07724239,0.057149082,-0.016882852,-0.036840387,0.037105355,0.0583788,-0.046971474,-0.011038441,-0.0739153,-0.09185962,0.07283866,0.054006375,-0.051262584,-0.037429493,-0.087218955,-0.033882815,-0.056509964,-0.042159535,0.04970049,0.14354482,0.012412466,0.10060975,-0.016640708,0.0007965599,-0.084219106,0.004860884,0.0019143805,-0.0086019505,-0.016754601,0.097023726,0.026872896,0.044017904,0.01885179,-0.029939787,-0.02723553,0.008989127,-0.056374654,-2.0121613e-05,-0.061650794,-0.0803569,0.09352899,0.04164668,0.003835017,0.04992032,0.06743908,-0.034142047,0.04722726,0.0160672,0.0075081117,0.0036296193,-0.13385966,-0.08285327,-0.009743434,-0.05251835,-0.037772283,0.0019209584,-0.024651708,-0.051540397,-0.0010169855,-0.053060092,-0.06301321,-0.05326204,0.030655399,0.055083796,-0.05068457,0.05127618,-0.05067416,0.03361375,-0.0802522,0.07177438,0.03578656,-1.6321314e-08,0.041869387,-0.10633576,0.014956382,-0.06433229,-0.030470064,0.046322662,0.0055053323,0.045997996,0.08100998,-0.014333698,-0.007356991,0.07141564,0.067530915,0.06980791,-0.0065542418,-0.026045384,-7.71188e-05,0.03009577,0.010996985,-0.061656825,-0.1527466,0.0013792777,0.027590571,0.027631793,0.02605909,-0.04171365,0.023249624,0.13822515,0.046611007,-0.057173934,0.05832406,0.0060804994,-0.009863151,0.0184882,-0.035840563,0.08247209,0.05109364,-0.037626803,0.0033310743,0.05092982,-0.052244715,0.019285139,-0.036542132,0.052509088,0.0100199655,-0.075879335,-0.010939569,0.02583357,0.04070807,-0.055952806,0.0011618459,0.039124455,0.01859391,-0.017283402,-0.050834127,0.017043903,-0.025511714,-0.030140433,0.044204265,0.007949273,-0.001436846,0.014475282,0.11983027,0.0075909276 +3.5.4.4,"The enzyme, found in a wide variety of microorganisms, plants, invertebrates, and animals, plays a role in purine metabolism.",384,1.0,-0.02776074,-0.02611784,-0.07724076,-0.011983749,0.011950174,0.085730895,-0.020102251,0.00538285,-0.009925131,0.0015876901,0.00472881,-0.07787279,-0.09492596,0.031881746,-0.058624737,0.025523474,-0.072963595,-0.0153706465,0.09122504,-0.08180361,0.04561522,0.03651412,-0.04913763,0.006604036,0.018955095,-0.0036867904,0.004127687,-0.062634945,-0.07298675,-0.075759865,-0.02236538,-0.02121927,0.08875561,0.004466597,0.038129605,0.12542737,-0.05882192,-0.053349253,0.03854612,0.031843018,0.001896269,-0.019961128,-0.05177423,0.023354428,-0.05698591,-0.042233292,0.03457468,0.013801049,0.050116476,-0.008884947,-0.048825603,-0.015228037,0.025640922,0.044773843,0.0037744357,0.010765092,-0.013938337,-0.0028661808,-0.12608701,-0.05487642,-0.007848707,0.00938725,0.00845649,0.00017779665,0.048106324,-0.06456898,0.018773984,-0.021653656,-0.014908252,-0.09659747,0.008226798,-0.106525086,0.0026995041,0.0059260046,-0.06829825,-0.019886225,-0.055321366,-0.03643686,0.061938036,0.020865649,0.07482719,0.044515062,0.010150169,0.028979188,0.05173819,0.0076509807,0.017946592,0.025713062,-0.010091382,0.024870476,0.041056428,-0.017555073,0.020100702,-0.06364962,-0.0012079724,0.043002494,-0.0043247966,-0.019847278,0.092721164,-0.08237803,-0.014910355,0.076502755,-0.017466523,-0.052918456,0.01258035,0.026895985,0.0045348094,0.07127804,0.080931924,-0.010865869,-0.044885375,0.07664646,-0.017504677,0.0713492,0.06808043,0.08042187,0.04908498,-0.1015918,-0.056110535,0.010566003,-0.042528678,-0.02842672,-0.024375206,0.08019082,-0.017442886,0.082803346,-0.0674396,-4.8617488e-33,0.030173762,-0.015339126,-0.018001173,-0.03459878,0.032055594,0.019521223,-0.06747495,0.0061807805,0.012923038,-0.038864665,-0.10840395,-0.080338135,0.0025309878,0.047972765,0.01761811,-0.020805411,0.00096071407,0.024458176,0.17317607,-0.013989051,-0.010563486,0.022123467,-0.05650417,-0.012333161,-0.01767385,0.10814837,0.010160072,0.053298127,0.035914287,-0.043409385,0.014452628,-0.093376935,-0.064539656,0.01757703,0.07633618,-0.05769163,-0.051095773,-0.005791155,-0.05302206,0.09822633,0.036140107,0.00045517014,0.055890333,-0.033429466,0.047785122,-0.05220924,-0.1135346,0.04620977,0.054591637,0.07035461,0.03524795,-0.008487295,0.10562098,-0.04643148,-0.008562213,0.048167024,-0.014749554,-0.05312981,0.00037670418,0.04166482,-0.013800749,0.04292969,0.016523229,0.020557245,0.03600389,0.008205781,-0.0925567,-0.03626038,-0.0057832194,0.1695533,-0.06748862,-0.048932835,0.012358718,-0.0550125,0.046001907,-0.026723683,-0.09939193,0.011053169,-0.028339004,-0.027212232,-0.011422097,-0.053187918,0.03905554,0.035987455,-0.022793775,-0.017788924,0.010116719,-0.038885377,0.03142859,-0.0030409237,0.07401798,-0.04923288,-0.07154287,0.0035179078,0.033026908,9.828837e-34,0.078025356,-0.12451139,-0.0035955263,-0.08239597,-0.07141334,0.11021798,-0.026138404,-0.013712121,0.059276503,0.06273656,0.013519049,0.031325012,-0.03083109,-0.09501584,0.05081998,0.05565448,-0.0051104836,0.05018018,-0.013009509,-0.031412963,-0.044116806,0.035941277,0.0101367645,0.041873027,0.051837396,0.006015259,-0.006031262,0.0071941298,0.057686966,-0.0369659,0.0031131608,-0.021140793,-0.009948985,-0.051623795,0.010664144,-0.0013186958,-0.059822574,0.0030170889,-0.004341697,-0.00865287,0.03146115,0.041700788,-0.01884626,0.045145452,0.036421917,0.04260532,-0.08906374,0.014624807,-0.019732913,-0.050911427,0.05773046,-0.022701206,0.07742246,-0.050581384,0.052766267,0.01772653,-0.03937147,0.009127956,0.022853257,-0.036325376,-0.009896856,-0.06092517,-0.01350695,0.02569087,-0.044292144,-0.01874528,-0.034982417,-0.0085526565,0.006705071,0.02062543,0.036118146,-0.015308334,0.011231395,0.10538896,-0.08682435,0.0117007205,-0.014039832,-0.044352226,0.08987026,0.016761746,0.0048950603,-0.0003716254,-0.019341595,-0.10091777,-0.048336435,-0.07670616,-0.0012010905,0.0896772,0.028226165,0.047545552,-0.023763256,0.009405788,-0.092277326,-0.043250952,0.055775646,-2.8771412e-08,0.064087234,-0.069803454,0.027556524,-0.036026422,-0.011387613,0.014483405,0.05438967,0.021806717,0.07454679,-0.027148342,-0.015210474,0.041403145,0.07212774,0.04565855,0.051660743,0.043092858,0.02175821,-0.03250418,-0.019029837,0.031180386,-0.1430269,0.030982433,-0.11975497,0.07930052,0.022846578,-0.043878235,0.041602775,0.11372748,-0.016920183,0.016144011,0.017889954,0.064521275,0.0082803145,-0.03770054,-0.006217361,0.04596849,0.023369357,-0.065140344,-0.027145797,0.03344907,-0.01968393,-0.04301518,-0.038433578,-0.04326333,-0.021349376,0.0021116063,-0.00948474,0.021142408,0.03266956,0.037208755,-0.0072214548,0.01663023,-0.05225072,-0.04534653,-0.056822218,-0.013684212,-0.011540082,-0.14315979,-0.03368947,-0.08802237,0.06977485,0.052114084,0.18950565,-0.021740953 +3.5.4.5,"Contains zinc. Catalyses the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.",384,1.0,-0.059900228,0.059660994,-0.01368782,-0.020547982,0.11418647,-0.0059170313,-0.027868047,-0.011321292,-0.048989855,-0.0063849716,0.014267309,0.0049105925,0.013705128,0.021398634,-0.034857854,0.040678103,-0.026535463,0.039723936,-0.007959111,0.00364976,0.00022117684,0.001517625,-0.018575987,-0.028888075,-0.000117009586,0.03824986,-0.006886867,0.005695309,-0.023930117,-0.028636588,-0.036633644,-0.026248015,0.08382904,-0.07601461,0.053613953,-0.018828187,-0.06099066,-0.0012566808,0.021382423,0.055831037,0.0015473024,0.13340202,-0.06087028,-0.010461445,0.05133958,-0.028703297,0.006079449,-0.03795244,-0.06841253,-0.020403815,-0.019632783,0.0532822,-0.023629226,0.024253042,-0.0023620503,0.0060645067,-0.09961995,0.032004442,-0.061566208,-0.014050914,0.014457789,-0.04003916,-0.021426603,-0.039233975,0.0893751,-0.02961017,0.032429818,-0.04351014,-0.01102287,-0.03461699,-0.014164714,-0.08804915,-0.04066982,0.06785211,-0.011755236,0.005871484,0.08212183,-0.04593098,0.014593883,0.05521602,0.010950904,-0.024726799,-0.0068742945,0.07132903,0.090771385,0.03267315,-0.07558759,0.015276354,0.008652837,0.033101965,0.03520288,0.0457491,-0.00064205227,-0.04136633,-0.003921153,0.035320766,0.01614056,0.08587962,0.048501864,0.0009309202,0.026166892,0.046167225,-0.047333777,-0.123431146,-0.04181439,0.0023681803,0.08295663,0.046056658,-0.019791724,0.018786428,-0.016548118,-0.027478298,-0.02918756,0.01378363,0.018026039,0.095650844,0.11354935,-0.016884508,-0.030983493,-0.091466956,0.020471932,-0.0570404,0.02328481,0.08642567,-0.049586646,0.054419164,-0.071377866,2.3803994e-33,-0.07787665,0.01698758,-0.011605319,-0.0072628967,0.035745416,0.042359997,0.0070772497,0.0877925,0.0273154,-0.07326691,-0.1248266,-0.020590281,0.038613282,-0.004129156,-0.068575285,-0.12068146,0.059951138,0.018080601,0.099460624,0.001514717,0.07623569,0.08133835,-0.0003443624,-0.033288047,0.02584886,0.03733374,-0.025489835,-0.06877843,0.029928653,-0.032789417,-0.0024022148,-0.10856569,-0.091743015,0.016403291,0.03660664,0.01887072,-0.08428104,-0.003641507,0.04941968,0.04230198,-0.055490967,0.0062103975,-0.011465285,0.029266581,0.031210553,-0.022922257,-0.12061671,0.057398133,-0.011783412,-0.04628612,0.06574295,0.0055232304,0.007239251,-0.042633753,-0.09505977,0.04189609,-0.0022526837,-0.018407308,0.023522899,0.07867653,-0.015720857,0.043404184,-0.062733404,0.040408075,0.03324517,0.0028834941,-0.08843698,-0.02460061,-0.0023556165,0.06836466,-0.057173964,-0.03150312,0.054916915,0.04212661,0.05050316,-0.02856545,-0.06494966,0.0750651,0.0925059,-0.003818377,-0.029591663,-0.04491472,-0.04026521,-0.0026365877,0.008116767,-0.040926,-0.034720514,-0.039724775,0.032338724,0.07836447,0.03643607,-0.07102112,-0.054761544,-0.006430312,0.07722939,-5.295452e-33,0.10658885,-0.059093136,0.014208538,-0.094008766,-0.032916255,0.0054982,0.008018796,-0.112260364,0.056511182,-0.04124814,0.018021686,-0.05863709,0.04659448,0.013570441,-0.039865542,0.016289208,-0.0040626186,0.1599585,0.01612898,-0.047844965,-0.008884513,0.010598015,0.06150117,-0.0047791675,0.016867874,-0.0047838236,-0.012892062,0.028156178,0.11795008,0.03288868,-0.03739956,0.029887047,-0.019608568,-0.10090246,-0.016096111,0.0823042,-0.05262008,-0.034972604,-0.028521525,0.0013037224,-0.037362248,-0.013849702,-0.029299377,0.12937342,0.063896574,0.091110125,-0.084364995,0.014345868,-0.01571959,-0.02893341,0.12044665,0.020563748,-0.04274765,-0.00785105,0.052847397,0.057013366,0.016971078,-0.017947976,0.0061004423,-0.021711808,0.009951322,-0.027512563,-0.046781234,-0.0027888082,0.01603956,0.014249205,0.02346706,0.073177844,-0.023251457,-0.03269805,0.013271047,0.02120369,-0.013878074,-0.0132249445,-0.07632735,0.06151802,-0.034458876,-0.029225312,0.055565596,-0.02236599,-0.032693338,-0.018556433,-0.009285234,0.02214039,-0.08457465,-0.053432394,0.017810082,0.06955048,-0.061715897,-0.037022788,-0.04764444,-0.06235719,0.0062492774,0.066685945,-0.011354719,-3.825206e-08,0.0226939,-0.07348902,0.0028122407,-0.041432995,-0.06587029,0.035037015,-0.01845661,0.033666752,0.03149918,-0.084960915,0.030498864,0.09344651,0.0029289408,-0.033153497,0.026176134,0.019611748,-0.055185635,-0.003032569,0.02072736,0.015224666,-0.033228245,0.059768483,-0.15232475,0.037244983,-0.015919713,-0.04413637,0.016038748,0.021786751,0.025565995,-0.04790083,0.059709374,-0.04126765,0.046792395,-0.004459564,-0.011965254,-0.062947854,-0.014115193,-0.12011382,0.013142492,-0.040833876,-0.06547552,0.03483357,-0.0972583,0.004203168,-0.0077410587,-0.06670152,0.023820268,0.02126006,-0.045164723,0.016169036,0.00092174456,-0.051822126,-0.0102090165,-0.080961674,0.010528284,0.00446474,-0.0061012404,-0.09146063,-0.047198206,-0.009007256,0.0058811773,0.02528104,0.24726547,0.0007968406 +3.5.4.6,cf. EC 3.5.4.17 adenosine-phosphate deaminase.,384,1.0,-0.07827369,-0.031970907,-0.03016531,-0.03616826,-0.006615885,-0.05126074,0.025674414,-0.004566202,0.034888417,0.0296642,0.0844332,0.00248766,-0.07260189,0.035118718,-0.027683899,0.0006135237,-0.039819047,0.0053007673,-0.031246878,-0.07784281,0.031878382,0.06287032,-0.06134953,0.04623859,0.04885769,0.059426926,0.060470667,0.060453806,-0.028572636,-0.09906894,-0.08399492,-0.07265518,0.05214552,-0.07052737,0.055147126,0.07484745,-0.1107886,-0.030958544,0.040357094,0.0028793795,0.051691215,-0.01979416,0.015989203,0.038869288,-0.018533958,-0.03238859,-0.105974406,0.07291263,0.09176396,-0.0037976492,0.02864935,-0.0040994952,0.005295986,-0.0145019945,-0.0066152676,-0.034478866,-0.066575944,0.029962044,-0.016226921,-0.024489708,0.05260553,-4.961308e-05,-0.021917097,0.01097327,0.050264075,-0.03179397,0.135212,-0.064676076,-0.03467693,0.06155744,-0.03626807,-0.06405133,0.037122726,0.04819937,0.037605397,0.021316547,0.013916688,-0.07005175,0.025339046,0.024820898,0.14419763,0.077846594,0.05590021,0.06894434,0.022222295,-0.004376898,-0.04078654,-0.024373628,-0.023866953,-0.02496372,-0.013006093,-0.002128162,0.045009114,0.015413793,0.020285511,-0.014924931,-0.030260822,0.08886853,-0.016778162,-0.010634473,0.00010726266,0.1448853,-0.087601095,-0.049254794,-0.051614095,0.020683847,0.014373842,0.046137672,0.036949478,0.077027224,-0.022681216,-0.0086664045,-0.04435045,-0.026063887,-0.021503266,0.14304842,0.009664811,-0.054071702,-0.004882111,-0.022138042,0.0037435829,-0.07847453,0.026842302,0.07434019,-0.07646231,-0.011407882,-0.035962794,-1.6479039e-33,0.019878028,-0.044911217,0.06265776,0.024444072,-0.0051424,-0.006077781,-0.04590257,-0.021605324,-0.06497706,-0.022023324,-0.066222906,-0.02642981,0.036929656,-0.030015599,-0.024915172,-0.085607074,-0.020483954,0.06539262,0.012101624,0.03597452,0.03614611,0.053604364,-0.08147786,-0.00019702724,0.05560528,0.015986776,-0.12745078,0.02104832,0.11995039,-0.025004262,0.041515864,-0.07145685,-0.10580607,0.023674645,-0.073933296,-0.1253478,-0.094324544,-0.023052376,0.08106868,0.068393126,-0.010236557,0.05062306,0.03814447,-0.022337342,-0.0074975076,-0.04414307,0.00074134086,0.039578855,0.05209514,0.06029283,0.033257302,0.0021348612,0.04909322,-0.08007726,-0.015709452,-0.048671745,-0.011165901,0.015960727,0.029706776,0.048499335,0.061524216,0.067845576,-0.025273794,-0.0088523375,-0.040375017,-0.0038686462,-0.10077358,-0.029950216,0.023299418,0.04311988,-0.016282737,-0.024546456,0.07175848,-0.0025073532,-0.0026345453,-0.026483567,-0.029334618,0.048799027,-0.09381983,0.026274731,-0.009327177,-0.04273765,-0.015988948,0.053529557,-0.017096022,-0.01496278,-0.026156902,-0.019427435,0.02107886,0.03495349,0.035826866,-0.0030488595,-0.11353981,-0.03750283,0.018938027,-4.5112773e-34,0.1257065,-0.031650987,-0.030493231,-0.08935454,-0.059822634,0.036115896,-0.0032502583,0.01901123,0.061314166,0.022022825,0.07603414,0.028352143,0.020215144,-0.037712693,0.021902872,0.067395024,-0.07374896,0.0061617442,-0.07368872,0.026885716,0.04769218,0.05051101,0.048774388,0.03402115,0.013041822,-0.015021522,0.00626908,-0.048942942,0.042472012,0.0423498,-0.07233807,-0.005634047,-0.06592132,0.05901687,-0.06765479,-0.020213604,-0.017284408,-0.064726196,-0.0706541,-0.04177203,-0.020280864,0.11617762,0.025029073,0.07270939,0.024019072,0.08472227,0.0641154,0.010429651,-0.018291626,-0.044907548,-0.012096824,0.051958065,-0.021866035,0.07977134,-0.027182993,0.0587156,0.030336337,0.052480154,0.024457129,0.008576476,0.01625594,-0.027456157,-0.041070364,-0.08176771,0.024829596,0.01343381,-0.078236535,0.0906153,0.0387484,-0.0061394963,-0.00223268,-0.0148776295,-0.02086889,0.03267948,-0.04043142,0.017887753,-0.031000834,-0.058882374,0.025319673,3.325016e-05,-0.04483702,0.021160575,-0.051608842,-0.0051152925,0.017883664,-0.012995852,0.035648365,0.049427,-0.08499785,0.09912703,0.03318601,-0.10902518,-0.01709355,0.1267434,-0.043240648,-2.2247258e-08,0.06443395,-0.043492515,0.02094149,-0.08076177,0.011294869,0.00014525103,0.047440134,0.053388737,0.060457297,-0.03874521,-0.0008924414,0.013348765,-0.011643615,0.02282171,0.06534592,0.00227967,-0.041312482,0.04186289,-0.004551098,-0.07191313,-0.051970113,-0.02938982,-0.111000374,0.05865357,-0.006838484,0.061011035,0.10799584,0.05873894,-0.022970524,0.017000686,-0.020559192,0.0036564174,0.016921852,-0.10259108,-0.010249272,0.023209678,-0.016878586,-0.0022441351,-0.102647826,0.00028417414,-0.050432466,-0.05643504,-0.037676495,0.027149433,0.02666316,0.05574615,0.011404306,0.03163716,0.003049579,-0.06091307,0.019983035,-0.06748271,-0.004027403,-0.006523415,-0.06963839,0.00567388,-0.04762732,-0.023858752,-0.0127148675,-0.037942093,0.023446077,0.035929497,0.16766709,-0.027101958 +3.5.4.8,"Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].",384,1.0,0.012563992,-0.006181372,-0.0811851,-0.043423176,0.099873245,-0.05785804,-0.0012943988,0.05331794,0.016364267,-0.009360929,-0.0035737355,-0.018651087,0.03987667,0.114121504,-0.060984764,0.036345992,-0.024342436,0.012989747,0.009046093,0.013411263,0.09376601,0.025561737,-0.016520834,-0.0059260353,-0.024478544,0.014767578,0.06929331,-0.03242421,0.00069523975,-0.07763668,-0.030294446,-0.059523273,0.060608905,-0.13450421,0.07903087,0.114432104,-0.007349069,-0.0484929,0.09257652,-0.06215948,-0.0023345065,-0.0613321,-0.006145046,-0.022143638,-0.035862062,0.0010979434,0.05476461,0.014186934,0.025887663,0.054150455,-0.068240814,0.0018758813,-0.039825354,0.010044199,0.0016789172,-0.04893832,-0.124093205,-0.04673141,-0.054616094,0.009120282,0.051692605,0.06426772,0.03315097,0.00703113,-0.03127486,-0.032617144,-0.019633096,-0.06753931,-0.021995267,-0.024222419,-0.05524172,-0.062249217,0.03859146,-0.027687643,-0.018593468,-0.013632455,0.08093457,-0.055176076,0.037705522,0.012111967,-0.02571989,-0.028762339,-0.015638428,-0.008857496,0.027753262,0.034224655,-0.011236387,0.005412886,0.025578234,0.07674062,0.015477743,0.082219034,0.03155573,-0.027202249,0.03912261,0.04609244,0.008318809,0.039542764,0.064679995,-0.007703621,-0.045525372,0.08001411,-0.009782333,-0.06673592,-0.065081656,-0.092516236,0.014317688,0.13915756,-0.038837254,-0.0128006395,-0.060223587,-0.048293196,0.06358982,0.057768475,0.05813386,0.095023625,0.0691137,0.0040990678,-0.09797363,-0.0059185144,0.047563393,-0.019349484,-0.006466492,0.048594806,-0.015245317,0.0797509,-0.06281371,2.1097626e-33,0.02804736,0.09482455,0.0011404247,-0.035501815,-0.01638937,0.04712019,-0.042354412,0.04065953,0.011270002,-0.00071513536,-0.053206682,-0.127689,0.015820498,-0.055645376,-0.06432974,-0.093737915,-0.006353482,0.051627543,0.051388033,0.03570237,0.04152754,0.08163143,-0.013759996,-0.008184079,0.024565585,0.08569938,0.030463044,-0.019277057,0.004175369,-0.019675065,-0.011445489,-0.09377873,-0.12363597,0.000566775,0.06502288,-0.021052003,-0.029117461,-0.009787557,0.03127655,0.040232178,-0.043607462,0.02190899,-0.013419224,-0.04663135,0.03223706,-0.006169356,-0.063200586,0.1104681,0.040552296,-0.045812655,0.04439478,-0.03008083,0.055962626,-0.02001909,-0.03245694,-0.00054489216,-0.056161713,0.040333997,0.02621738,0.012023152,-0.023773711,0.06144184,-0.054525655,0.010100869,0.023569966,-0.10037069,-0.040697314,-0.018893816,0.0018643177,0.06879797,-0.055368934,-0.047435544,0.035579972,0.024334531,0.038119048,-0.08779256,-0.09459172,-0.0059307166,0.07501682,-0.010763426,-0.0072863693,0.031880926,0.008678347,-0.020769315,0.02156119,0.049254764,-0.03665253,0.006193205,0.016228082,0.054647923,0.033550248,-0.11892386,-0.08784133,-0.0059343628,-0.042198583,-2.4904707e-33,0.06651869,-0.06599255,0.040062305,-0.004403357,-0.073984645,0.012765097,-0.023313863,-0.018332934,0.0056505008,-0.011244232,0.010651925,0.014559433,-0.00694452,-0.056528024,-0.039890666,0.038157016,0.068413645,-0.01553184,-0.026519025,-0.07047315,-0.043473322,0.11166525,-0.0021198804,-0.032897886,0.070832446,0.0616542,0.01879165,0.067081824,0.08260038,0.095174685,-0.060197785,0.021189742,0.009427587,-0.03967336,-0.026902292,0.009771452,-0.04353347,0.0050161635,0.027522113,-0.02293066,0.021340081,0.020060176,-0.0012509852,0.10019932,0.01436518,0.069000386,-0.061760455,-0.010619558,0.045521624,0.056891978,0.0013813495,-0.029314395,-0.0647206,0.0051781447,-0.0035697317,-0.021634646,-0.002008786,0.01829122,-0.053859722,0.0035661852,-0.05793041,-0.07735934,0.08917527,-0.039325565,0.11736509,0.031268276,0.010593512,0.12878953,0.03748024,-0.0130962515,0.063534565,-0.042032447,-0.010630027,0.0105675915,0.02312909,0.026443405,-0.058193076,0.007033651,0.015233186,-0.0559532,-0.005887875,0.02078691,-0.0038826624,-0.09635458,0.0066300356,-0.07062984,0.036516827,0.13849886,-0.00029021257,-0.01961838,0.0082177585,-0.03013561,0.009321482,0.025965402,0.040010802,-3.758325e-08,-0.05702441,-0.06125704,0.07765849,-0.03974618,-0.0049952003,0.074680045,-0.0076284986,0.0016559599,0.11905178,-0.0319714,-0.041564472,0.049762208,0.08266063,0.0047428966,-0.009666712,-0.00069798063,-0.003985345,0.041090388,-0.026735647,-0.050889708,-0.09007425,-0.040864818,-0.17163907,0.03627705,0.047690377,-0.081750266,0.019910617,-0.03494619,-0.0042115687,-0.01622877,-0.07933228,0.03757318,0.054462012,-0.023416676,-0.068503745,0.02560958,-0.03468585,-0.03392241,-0.01518869,-0.0032917338,-0.011855775,0.0215851,-0.06795544,-0.017774299,0.0070063258,0.019575553,-0.043789525,-0.0005428627,-0.061274365,-0.020954065,0.039549414,-0.023548232,0.03491553,-0.06735596,-0.041266363,0.024774522,0.019702237,-0.021607189,0.04782656,-0.035991203,-0.0071789757,0.0069453875,0.2088899,-0.04111353 +3.5.4.9,"In eukaryotes, the enzyme occurs as a trifunctional enzyme that also has methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and formate---tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes, it occurs as a bifunctional enzyme that also has dehydrogenase (EC 1.5.1.5) activity or formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.",384,0.99999994,-0.011995949,-0.042654347,-0.108164154,-0.062237013,0.007852955,0.007342712,-0.10900216,0.078902565,0.019763248,0.026466276,0.056304663,-0.06654036,-0.07120978,0.06209768,-0.0010116702,0.0067974147,-0.09409812,-0.019244844,0.05582221,-0.056431625,0.06855143,0.028887074,-0.037316445,0.0049720127,0.024700755,0.004689907,0.0334554,0.009072094,0.0075310334,-0.014507675,-0.016905384,-0.009156906,0.0046772873,-0.0147853615,0.012407265,0.13051657,-0.062378436,-0.079130106,-0.020203386,-0.013743468,0.016425308,-0.023235342,-0.09601996,-0.009780883,-0.024571156,0.04532346,0.056862887,0.036690604,-0.026676282,-0.0021993893,-0.03237641,-0.015401318,-0.0056785727,0.012858889,0.0030689086,-0.01280809,0.026000546,0.0044080596,-0.007770839,-0.014415401,-0.0055267336,-0.037311144,-0.012219588,0.0280686,0.042360686,-0.04743438,0.12185757,-0.06515268,-0.043522503,-0.05465243,-0.09068488,-0.057661153,-0.04828622,0.07973272,-0.08289005,0.05799077,-0.0145941805,-0.060118098,-0.005226464,-0.014267368,0.035170976,-0.0062009036,0.015074331,0.0018144839,0.038957614,-0.045400456,-0.032273825,-0.004176492,0.016348291,0.03815075,0.025944985,0.04484296,-0.0485925,-0.012350037,-0.10277559,0.046229333,0.060946625,0.05248197,0.081784986,-0.09926855,0.023724392,0.07803846,-0.044251658,-0.012508154,-0.020612229,0.018399421,-0.015260113,0.08809863,-0.024930386,0.032081783,-0.045645792,-0.03911441,0.033687413,-0.036966294,-0.0068445974,0.09264035,0.025298785,-0.0330196,0.0028470107,0.04792782,0.011301375,-0.011960033,0.07323641,0.065509334,0.0019939118,0.040874105,-0.13941559,2.1420565e-33,0.08158545,0.010369636,-0.05422884,0.019949922,-0.009571526,0.023480784,-0.048944302,0.07560814,-0.031508334,-0.054801702,-0.07454434,-0.014443913,0.093421675,0.0007266764,0.0070419223,0.013388714,-0.0017217088,-0.04262439,0.0073984894,0.09190692,0.01219882,0.042946853,-0.020487746,0.038219377,0.031449523,0.042458188,-0.008369749,-0.00042893447,-0.022288179,-0.008276001,-0.024093185,-0.20667893,-0.12740093,0.0008172083,0.13218391,0.029834855,0.028888367,-0.02024723,-0.05285351,0.031204782,-0.017580016,-0.039673623,0.020031314,-0.060734466,0.052484892,-0.05615059,-0.033615097,0.07548641,-0.0027144202,0.01343805,0.05783572,-0.023972692,0.10751384,-0.07318694,-0.05317403,0.0840276,-0.031449445,-0.037152477,-0.00057458866,0.097755186,0.0021411534,0.039816987,-0.060214706,0.029420493,-0.023308698,0.008730872,-0.07512449,-0.07222662,0.020118607,0.005133091,-0.057591725,0.040166833,0.13820137,0.015775118,0.05001756,-0.005418345,-0.042433247,-0.040694054,0.039920107,0.03679564,-0.027136201,-0.018583715,0.035993505,-0.030213563,0.0284399,0.013611057,-0.020617718,-0.03817538,-0.026656136,-0.006411361,0.06979805,-0.068611965,-0.010624655,-0.032393157,0.061757635,-4.626897e-33,0.0856769,-0.025430577,0.006122352,-0.13218114,-0.0063923965,0.14412418,-0.017283384,-0.05550767,-0.0039269463,-0.0664598,0.07423306,-0.03455063,0.020189952,-0.047356527,-0.032425415,-0.01677771,-0.035295665,0.112108395,0.018479519,0.01265934,-0.012357443,0.057881746,0.039182287,-0.010088475,0.06254421,-0.03130405,-0.01827715,0.033968322,0.02765481,0.0355193,-0.051432278,0.01374283,-0.016294086,-0.014477901,-0.004629548,0.08497675,-0.120437264,-0.02336882,0.05800694,0.03789321,0.018111724,0.06338865,0.00082509243,0.046285428,-0.021559166,0.042382527,-0.10794361,-0.016262349,0.013519364,-0.050938334,0.04256545,0.02769168,-0.013533343,0.04288732,0.038345914,0.036639478,0.038561847,0.07669406,0.003914974,0.003253818,-0.0027276638,-0.04414871,0.04946802,0.023121748,0.033835486,0.017552068,-0.042674217,0.005557116,0.046379864,0.007241843,0.03733547,0.013220428,-0.03620631,-0.0069872406,-0.03482087,-0.039611015,-0.08176237,-0.031143624,-0.019380838,-0.010237912,0.05867273,0.00061874144,0.011312585,-0.04312425,-0.028192056,-0.07914497,0.004260923,0.086427264,-0.025594184,-0.035275087,-0.021758175,0.0057178275,-0.07602979,0.07309209,0.048265867,-4.9460127e-08,0.016390063,-0.019052582,-0.015313606,-0.106494494,0.083536565,0.048102904,0.020493675,-0.04425302,0.031773724,-0.015230781,0.014823921,0.046857134,0.0055125183,0.0039120186,0.0730111,0.027582431,-0.0075138933,0.043601297,0.0075901723,0.046238255,-0.044140343,-0.01888722,-0.13397445,0.061099805,0.0013022205,-0.034713395,0.0037488826,0.019066432,0.074468255,-0.010688522,-0.0646838,0.03877807,-0.008700997,-0.027880553,-0.10130374,0.019836886,-0.03001829,-0.0012296519,-0.0877107,0.08268767,0.016490376,-0.07038642,-0.085654296,0.03036149,0.035104528,0.03034315,0.035776094,0.02715457,-0.02838836,-0.032122042,-0.0013046552,-0.018537866,0.01809774,-0.053753458,-0.07005071,0.030454297,-0.038971614,-0.10698425,-0.0314578,-0.03689932,0.026837979,0.047376648,0.20767199,-0.06565055 +3.5.4.11,"The animal enzyme is specific for pterin, isoxanthopterin and tetrahydropterin.",384,1.0,-0.039600566,-0.104009554,-0.06389642,-0.012271128,-0.0031237376,0.027045881,-0.03308906,0.020176457,0.035107344,-0.019606654,0.07677001,-0.058663353,-0.17835118,0.050359808,-0.033698056,0.014634407,-0.03766661,0.009328802,0.051335007,-0.10321156,-0.037255738,-0.0170944,0.01146028,0.01048502,-0.0457678,-0.04894579,0.0037984313,-0.03942648,0.026612872,0.01264658,-0.067057185,-0.0448661,-0.010748439,0.0036599906,-0.0053438866,0.05432712,-0.054154344,-0.026510902,0.06375441,0.017775359,0.11947523,-0.066182055,-0.03361272,-0.032274865,0.00091596326,-0.055864234,-0.04480016,0.006841697,0.043430243,0.05509957,0.01401273,-0.033048976,0.000102676386,0.016162474,-0.027724814,-0.058712546,-0.007807538,0.020951997,0.040709693,0.030373562,0.033609897,-0.017178006,0.05200611,-0.008770181,0.06958959,-0.061530776,-0.011616394,0.015087736,-0.010644062,-0.12833035,-0.016013157,-0.011293305,0.0054823086,0.03306078,-0.06588887,0.046948966,-0.053298347,-0.05333983,-0.018943565,0.008898938,0.03742016,0.033890378,0.011131785,0.102059536,0.07252401,0.023927351,0.0012244055,0.024162417,-0.0710981,-0.004678394,0.10191805,-0.010507372,-0.01630714,-0.026889548,0.010860952,0.0032044167,-0.012167109,-0.026380165,0.0019179264,-0.033551916,-0.0768252,0.01461174,-0.0880377,-0.08827269,-0.030923208,0.017630998,-0.05857661,0.007242879,0.10287609,0.028012287,-0.053743467,0.017057879,0.051458158,0.011614505,0.052296285,0.08458188,-0.072030485,-0.058838133,0.104700446,0.054605287,-0.0023705123,0.028378768,0.021359688,0.13875577,0.030399473,0.032156803,-0.033851303,1.2827029e-33,0.06647548,0.032388203,-0.0016211661,-0.024080187,0.027030151,0.0053458386,-0.012072243,0.011835599,-0.028566997,-0.039380196,-0.086469725,-0.08926588,0.024038874,0.0126798265,0.06592363,-0.04558237,-0.012150977,0.0014404552,0.0797381,-0.027099978,0.018591803,0.0897939,-0.08446764,0.07160982,0.07448633,0.052313644,-0.11723606,-0.007159846,0.012240103,-0.03322422,-0.025009863,-0.06492532,-0.0720898,0.045404565,0.000940613,-0.044610087,0.025146315,-0.07598423,-0.056042407,0.015825413,0.06404723,-0.037648275,0.056594532,-0.006809957,0.06976327,-0.064011425,-0.05595873,0.019529436,-0.009038814,0.010707832,0.025120068,0.02259837,0.07582077,-0.09332156,-0.037081946,0.010383433,-0.03339161,-0.009349551,0.053724527,0.062569365,0.006045223,0.04739579,-0.028766265,0.029469574,0.0054275896,0.013020646,-0.06958108,-0.050391525,0.005321612,0.1021219,-0.08417226,0.05764178,0.061292317,-0.08147911,0.04847578,-0.008577798,-0.08175098,0.018489257,0.0048551885,-0.07079105,-0.05605638,0.0334063,0.0308028,0.025082137,-0.06550976,-0.012797435,-3.1341766e-05,0.037192922,0.03401447,-0.031028785,0.09337969,-0.00409976,-0.17264652,-0.021345159,0.03585532,-2.9991657e-33,0.056022193,-0.07372303,0.028701143,-0.06391718,-0.07610125,0.095645815,-0.014784425,0.01837805,0.06468744,-0.025848001,0.061808456,-0.024504943,-0.036730852,-0.032042988,-0.015457789,0.09107826,-0.0858525,0.051882185,0.004362746,-0.07941045,-0.112754434,0.009367375,0.0022184611,0.07702962,0.08001003,0.012891435,0.029633222,0.037573185,0.079833075,0.0042789513,-0.038605466,0.008315287,-0.04182651,0.0094347,-0.005987995,0.0070050443,-0.06747068,0.0018076027,0.028283203,0.020333191,0.028069705,-0.00029290357,-0.03283375,0.08233173,-0.024113433,0.05366303,-0.010668421,0.024482463,-0.017547583,-0.021699173,0.04368005,-0.02474556,0.07282851,-0.03646117,0.06605951,0.07358782,0.07201336,-0.079510055,-0.010914295,-0.0058167125,0.038964503,-0.02775437,0.046375602,0.07732117,-0.014338709,0.007691702,-0.03451377,0.020700067,0.056384243,-0.021281734,0.124964915,0.053653385,0.027283594,0.010056867,-0.012835459,-0.0065936977,0.040510472,0.017740369,0.048350435,-0.03411714,-0.060042787,0.0057108314,-0.0056915996,-0.021370977,-0.013655389,0.06426476,-0.018104061,0.11277814,0.049237203,0.02180312,-0.023787277,-0.024090834,-0.015231514,-0.006438559,0.007283288,-2.6383367e-08,0.08930056,-0.074739315,0.023825442,-0.08633908,-0.005026345,0.012927459,0.032444958,-0.011725764,-0.05787904,-0.0076087266,-0.016557522,0.015787497,-0.03104802,0.022619696,0.06715194,0.0019924494,0.040307023,-0.007415784,-0.003269176,0.019260176,-0.10720539,0.02132138,-0.09043832,-0.019043624,-0.05066303,-0.04991405,0.027938714,0.13197061,0.018229265,0.0019511923,-0.0035144547,0.00065830833,-0.024502924,-0.06933512,-0.029949453,0.11551388,0.024066815,-0.0782261,0.005118894,0.008297993,-0.04178762,-0.06070263,-0.056980163,-0.06464213,0.02065287,-0.027391588,0.06695397,-0.024112666,0.041864622,-0.029890103,-0.03500357,0.013096597,-0.033969834,-0.038789544,-0.06582707,0.04343861,-0.0248359,-0.08519551,-0.013282634,-0.06809959,0.0390421,0.020211551,0.18230557,0.034808002 +3.5.4.12,Also acts on some 5-substituted dCMPs.,384,1.0,-0.12351526,-0.07606954,0.0077198786,0.029904682,0.04655936,-0.004691011,-0.0070687807,0.02606822,0.015485532,0.07132705,0.06678388,0.00363908,-0.051216625,0.04399723,0.0107620265,0.06655039,-0.018909438,0.07542199,-0.052222677,-0.01245303,0.034016933,0.0029879007,-0.03143879,-0.061874412,-0.019330263,0.05371343,-0.011902974,0.0043972274,0.06280396,-0.09839661,-0.022996726,0.02762182,-0.029273497,0.006889889,0.0014184441,0.050988145,-0.0778335,0.008614963,0.023145746,-0.0052197855,0.110936105,-0.034646135,0.065301254,-0.051360387,0.042162385,-0.056908093,-0.014484012,0.026663711,0.013231607,0.047262065,0.050202377,-0.035578925,-0.020411855,0.052269917,-0.0701351,-0.008807818,-0.113054745,0.0057539395,0.06565233,-0.02767757,-0.035993624,0.03190438,-0.05426164,0.018889653,0.011236082,-0.07125475,0.068048745,-0.05296708,0.05022303,0.07875513,-0.009285542,-0.049750093,-0.0033950845,0.025443163,0.012623656,0.08091467,0.013182683,-0.089283995,0.1108041,-0.080002874,-0.03175402,0.031060321,0.016614795,0.04256342,0.04305807,0.056148425,-0.01686996,-0.05105436,0.019225532,-0.05108643,0.028096229,-0.016830646,-0.07513569,0.03661565,-0.107950464,-0.04600667,0.010519651,0.10101201,-0.040215746,0.037183713,0.011895376,0.052281633,-0.029483743,-0.062163834,-0.04431419,-0.06305192,0.014432247,0.06449775,-0.06979066,-0.030442497,-0.06038267,0.0054820776,-0.0066655218,-0.043728855,0.019179255,-0.005268162,0.0053171157,-0.008738443,-0.069512,-0.063903585,0.009026097,-0.034057684,-0.026003346,-0.022798171,-0.09649674,0.019321442,0.005136003,-2.1499494e-33,0.0143149495,-0.017026257,0.010898938,0.026290596,-0.032414183,0.021611223,-0.07011311,0.021698382,0.02277874,0.029356074,0.0065464755,0.046680525,0.06945559,0.061305042,-0.046333,-0.046938147,0.004981165,-0.04780184,0.047705058,-0.05399421,0.005767454,0.18884629,-0.05623747,0.019517012,-0.001697438,0.08903485,-0.012625503,0.011604461,0.050047312,0.02471231,0.01000477,0.04487541,-0.03592318,0.013632639,0.031057904,0.15164632,-0.028166309,-0.0086699305,-0.0027345938,-0.03439325,0.03914683,0.0032925399,-0.09101024,-0.024663148,0.013700752,-0.04704801,-0.077957846,-0.001119857,-0.01821996,0.0052243224,0.037867796,0.005863505,0.06658295,0.015637126,0.012801255,0.0021568004,0.0049720807,-0.013179821,0.035267312,0.04098919,0.005619723,-0.004141264,-0.043983098,-0.01235526,-0.017307399,0.032995407,-0.024206918,-0.027005916,-0.008744911,0.027066585,-0.046364695,0.058371443,0.075441465,0.034065682,0.0049573802,-0.012664884,-0.014386747,-0.009974615,0.009327573,0.022379654,-0.04687688,-0.08208945,0.001476014,0.004357765,-0.0040475405,-0.059640918,-0.024973566,-0.090838835,-0.042639077,-0.064790696,0.10905512,-0.054516666,-0.0198017,0.007811994,-0.04422561,3.1827503e-35,-0.054306228,-0.045859028,-0.034721572,0.10811961,-0.054066412,0.04424954,0.011528394,-0.0759284,0.0020470852,-0.068345465,0.05915085,0.024698995,-0.057922434,0.025580827,0.08194439,0.037231043,-0.06503363,0.030781731,0.0017863835,0.043529656,0.062155783,0.13343535,0.025815528,0.10686838,0.053225182,0.08983422,-0.040328182,-0.024967391,0.069616966,0.06896585,0.009119863,-0.0057741795,-0.05992019,-0.034347694,-0.0034561167,-0.0051971497,0.029636998,0.087546505,-0.06876196,-0.06819708,-0.0012454363,-0.012862418,0.07430671,0.11039311,-0.01155323,0.0491333,0.06576181,-0.025674136,-0.08023162,0.07181661,-0.03169273,-0.079913646,-0.12062924,0.007553229,-0.030330876,0.054766294,0.01746975,-0.05068618,0.021254096,-0.0018190484,-0.03461952,7.064314e-06,-0.02601177,-0.13532399,0.021965943,0.057085294,0.033837687,0.07453623,0.0613037,-0.090996735,0.15537904,0.062223416,0.015535335,-0.11855391,-0.050133727,-0.09123735,0.006242188,-0.06953447,-0.015598397,-0.04950526,-0.08038864,-0.01731604,0.049569514,-0.004949478,-0.05281983,-0.013589684,-0.038927227,0.060247213,-0.0089481445,0.045578174,-0.027393484,0.029837403,0.05353323,0.09832644,-0.0031344066,-1.7435116e-08,0.025092004,0.051891748,0.033923667,-0.04407267,-0.0031910788,0.0054023718,-0.042991992,0.04724071,0.023126934,0.062962025,0.09418042,0.06132316,0.057587173,-0.04251339,0.04407347,0.005827609,-0.06523315,0.037816603,-0.08328945,-0.048485205,-0.12731016,0.012819677,0.037648525,0.022581562,-0.02980149,-0.02785746,-0.0051918384,0.014034032,-0.035610907,-0.026395164,0.048756782,0.046475533,0.00797488,-0.023993682,-0.020699112,0.08740915,0.060039397,-0.093161345,0.0012910754,0.032059014,-0.033761516,-0.101881295,-0.030118076,0.06801813,-0.034043163,-0.03908104,0.017788831,-0.05702928,-0.022648228,0.018802484,-0.06472693,0.027285945,-0.03713534,-0.04467242,-0.046544578,-0.011279006,-0.03001001,0.012782118,0.076875895,0.00832466,-0.023582743,-0.0020807483,0.06211579,0.019275457 +3.5.4.16,"The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin-forming)] and EC 4.2.3.12 (6-pyruvoyltetrahydropterin synthase) [3].",384,0.99999994,-0.04965972,-0.08312618,-0.15560593,-0.027982932,0.059188593,0.0068454402,-0.042614724,0.039346468,0.048552614,-0.05913978,0.04576534,-0.08120554,-0.1532474,-0.022318816,-0.055296116,-0.016848922,-0.057152063,-0.019790703,0.008278078,-0.07242032,0.0071403827,-0.01824185,0.0042923433,0.025295299,0.08299268,-0.049046434,0.07030391,-0.038291067,-0.0009142242,0.0074162115,-0.009491113,-0.07940618,0.01772396,-0.070522934,0.053303942,0.10756311,-0.059820686,-0.09296483,0.013445624,-0.0282812,0.039053604,-0.0145123,-0.07076362,-0.046774026,0.03818261,-0.011218211,-0.013844321,0.12432875,-0.018526966,-0.0056268065,0.061175127,-0.04576677,-0.042673387,0.0322206,0.024136895,0.005150323,-0.032791898,-0.0017759582,0.062307786,0.028770017,0.03322546,0.047179163,0.04526654,-0.045435462,0.07054694,-0.1021619,0.071497746,-0.07989922,0.011021908,-0.08013106,-0.0681724,-0.014727873,-0.019646052,-0.011771072,-0.015945038,0.028649792,-0.04560504,0.0059618773,-0.009218026,0.04881241,0.057990935,0.033798676,0.026816199,0.07130726,0.05737726,-0.122686796,-0.03752377,0.04195645,0.018356288,0.016945275,0.018850373,0.016961375,0.021804936,0.023579348,-0.036632415,0.048547734,-0.03539962,-0.0032838248,0.030503161,-0.021909857,-0.0650082,0.11037075,-0.02804918,-0.08572045,-0.082142614,0.019815037,-0.04865839,0.11055033,0.03905235,-0.0041420665,0.026271049,-0.015489469,0.042965386,0.009465995,-0.018781157,0.06844747,-0.08097171,-0.048670806,0.006843734,0.06751798,0.018495958,0.008472307,-0.011840513,0.1286645,-0.008198942,0.039939776,-0.041867882,4.3873567e-33,0.033030897,0.05376487,0.006395678,-0.001877924,0.0719784,0.041823663,-0.06277953,0.024392484,0.013273734,0.0033457212,-0.03318971,-0.08203319,0.07496237,-0.016808005,-0.07396889,-0.036957324,-0.021659493,0.018010853,0.022792205,0.024722716,-0.020115847,0.11030578,-0.014309234,-0.004922484,0.025227552,0.064228505,-0.10080605,-0.016826607,0.102946036,-0.023823725,-0.0055386075,-0.042759545,-0.12104203,0.0430064,0.073967226,-0.0433415,0.004914357,-0.047748707,-0.016908769,0.084940895,0.033814047,0.016991291,-0.007372472,-0.07220543,0.12257816,-0.0050558522,-0.016624736,0.028202044,0.045915283,0.014827144,0.036654335,0.017464485,0.044322047,-0.047223166,-0.05085297,-0.05674099,-0.028630929,0.020935837,0.058737185,0.035138965,0.021010231,0.10340645,-0.04478193,0.018345775,-0.076042905,-0.011525915,-0.060367495,-0.021233283,-0.003448259,0.005215924,-0.10981375,-0.0019452178,0.0724089,-0.048036806,0.02834523,-0.0867544,-0.071322985,0.019922048,0.018212328,-0.022241805,-0.061244685,0.052518528,0.0029082478,-0.026472444,-0.032407768,-0.019620607,-0.10754291,-0.008026551,0.026347868,0.065459214,0.0016100788,-0.0016823501,-0.09775954,0.03892353,0.058446348,-5.0258566e-33,0.09409508,-0.08710969,0.02801314,-0.10597517,-0.03395833,0.03529753,-0.008534278,-0.034470767,0.05676517,-0.07521094,0.076179974,-0.026061827,-0.0051666372,-0.00034246224,0.030542688,0.024343034,-0.013897787,0.15088777,-0.07883527,-0.034289945,0.00695153,0.009309679,0.026098456,0.023829933,0.06629366,0.019603,0.03763435,0.046777043,0.13316882,0.04062534,-0.029961143,-0.036600057,-0.07731463,0.031903632,-0.0197828,0.06251812,-0.070335664,-0.01250483,0.0505253,0.040600438,0.050001282,0.026540713,-0.027963696,0.029155523,0.010860051,0.094851315,-0.046232723,0.050383125,0.030041572,-0.0020232568,0.08239604,-0.02435911,-0.046615195,0.019181434,0.0218605,0.023388587,0.072009645,-0.038052533,-0.01910558,-0.039896283,-0.017694399,-0.04080103,0.05654564,-0.019472146,0.02639531,0.01296668,-0.018141797,0.1298436,0.09772992,0.029008241,0.035652924,0.044736624,0.012971571,-0.011543431,-0.02784237,-0.03813322,-0.0049360762,-0.0805715,0.056379862,-0.110614896,-0.020072002,0.0029180364,0.031931728,-0.04710683,0.029792538,-0.050096232,0.022897797,0.065815434,0.018268015,0.044136923,0.0127193825,-0.035774775,0.017066281,0.054548036,0.062946975,-4.519082e-08,0.07091043,-0.06360699,0.025886947,-0.04496866,0.06627871,0.02801844,0.019969877,0.0045924224,-0.036703803,-0.03547734,-0.012584141,0.025051141,0.031008683,-0.031148857,0.014852782,-0.0061596343,-0.0076459325,0.013456683,0.009032868,-0.006937972,-0.070198074,-0.03210294,-0.07505914,0.03236236,-0.017131107,-0.09011381,-0.0024397576,0.03420488,0.0041249054,-0.023475165,0.048248786,-0.0005361326,0.010260236,0.022101538,-0.022416262,0.005389727,-0.05567451,-0.011295141,-0.042017173,-0.054491278,-0.051694334,0.009421203,-0.05175907,-0.028918898,-0.03307553,-0.03108783,-0.023999665,-0.005948957,-0.035531443,0.08947333,0.039821845,-0.0129007455,0.020809524,0.0013867088,-0.023955831,-0.011701509,-0.013547043,-0.07170158,-0.008673577,-0.053802695,0.0067867287,0.006515378,0.17640549,-0.04024565 +3.5.4.17,"Acts on AMP, ADP, ATP, NAD+ and adenosine, in decreasing order of activity. The bacterial enzyme can also accept the deoxy derivatives. cf. EC 3.5.4.6, AMP deaminase.",384,0.99999994,-0.09268778,-0.068437025,0.015685422,0.013052988,-0.041979924,-0.00059532904,-0.011361166,-0.03285248,0.022358939,0.08304788,0.07583037,0.0025499617,-0.042137492,0.10459991,0.03685779,0.051061064,-0.049292184,0.06465973,0.027675195,0.017129904,0.05678643,0.052443687,-0.068167076,-0.03114218,0.04983897,0.064057045,0.031302474,0.07411864,-0.062024176,-0.13335323,-0.04439679,-0.06280066,0.056695662,-0.062085122,0.02773036,0.09877444,-0.120232835,-0.012358367,0.09243045,0.013779869,0.014800635,0.057992917,-0.010821799,-0.0069644284,-0.020436652,-0.07647577,0.0050856676,0.019397099,0.044303034,-0.050143626,0.026320484,0.027860489,0.027071163,0.06139962,-0.008602083,-0.036510717,-0.04644309,0.016308585,-0.024248794,-0.06691913,-0.0059126657,-0.0070985234,-0.0043778084,0.016223447,0.004871615,-0.038290884,0.12730953,-0.027183544,-0.02237636,0.015388099,-0.063510485,-0.05944519,0.003513951,-0.011756345,0.049271118,-0.0073423004,-0.013283184,-0.08330306,0.015616586,-0.018036468,0.029878858,-0.013321907,0.012808217,0.03940456,0.011093244,-0.032418776,-0.013827575,-0.044460867,-0.032360405,-0.026586166,-0.01571961,-0.007422179,0.017078118,-0.0331242,0.009212101,-0.042787503,0.008583067,0.06843227,0.018362375,-0.017098326,-0.02182359,0.1267358,-0.14121784,-0.04502766,0.045372896,0.0010053689,0.058937825,0.08717792,0.012374487,0.044399656,-0.0046751513,-0.023919268,0.04020949,0.00264761,-0.025050025,0.11938114,0.053964596,-0.058997646,-0.08595746,-0.08426928,0.02529477,-0.1167758,0.013635469,0.013321597,-0.080963336,0.10264254,-0.032010175,-1.194716e-33,0.07358957,-0.09087382,0.01780744,-0.05542126,0.066252194,-0.04183038,-0.069322,0.019530017,-0.006579829,-0.047411818,-0.09500868,0.037648853,0.11110001,0.032386318,-0.049068805,-0.01926227,-0.03653827,-0.018994998,0.06689798,0.016222954,0.05130123,0.0016960276,-0.03282921,0.024712874,0.015293473,-0.0029079856,-0.031589188,0.06949911,-0.007014853,-0.015292567,-0.0043392773,-0.09815046,-0.10269365,0.03102015,0.052539255,-0.012753361,-0.057551805,0.03270388,0.04301764,0.0103728715,-0.043900233,0.04852068,-0.054741256,-0.011503961,0.012881066,-0.021272242,-0.0041960604,0.09373076,0.027776612,0.11041649,0.05868237,-0.053787168,0.051557865,-0.08532845,-0.05132076,0.016261183,-0.012037578,-0.009497896,0.0028701536,0.11185501,0.05785432,0.0719798,-0.030165428,0.002914149,-0.04808352,0.058801584,-0.061150137,-0.06399607,0.030460225,0.011958595,-0.07979472,0.03385048,0.036239102,-0.022832228,-0.009127229,0.025149727,-0.05852424,0.01990709,0.035532802,-0.0008103032,-0.01300086,-0.08310035,-0.007628117,-0.0068874387,-0.012871137,-0.035991725,-0.023034507,-0.02252682,-0.009018768,-0.013690091,0.020074617,0.025179565,-0.058538083,-0.021199863,0.06746436,-1.6811107e-33,0.09656452,-0.03310446,0.021807155,-0.10902032,-0.037779577,0.11469139,0.0007583852,-0.008992897,0.036837514,-0.022515383,0.029436095,0.05754234,-0.001963855,0.0071332436,0.039021894,0.0029012223,-0.08488453,0.021925284,-0.080746494,-0.009412989,0.008587018,0.12752728,0.013611544,0.014018725,0.0391364,-0.04154359,-0.021857174,0.03569663,0.043145724,0.031915564,-0.031052582,0.017865926,-0.05510713,0.017588444,0.010584255,0.07029686,-0.029767457,0.008299352,-0.053855624,-0.013136837,0.009322771,0.030248998,0.017029718,0.11504661,0.06696312,0.042064097,-0.057552416,-0.0079807285,-0.06918504,-0.0041049453,0.016526368,0.006480119,-4.1028623e-05,0.0022426627,0.04004023,0.0723429,0.056879923,0.015317304,-0.0024397057,0.0043462627,-0.035839155,-0.042119395,0.02886279,-0.055654682,-0.03686886,-0.015682193,-0.03381372,0.022161456,0.05430875,-0.05874873,0.040400263,0.0044287276,-0.029552156,-0.04745618,-0.09171521,-0.0063216523,-0.08838644,-0.038126588,0.04557336,0.013530163,-0.019174367,0.07809455,-0.032990675,-0.047277007,-0.01400241,-0.0057593873,-0.0119281225,0.018674878,-0.025107358,0.047482457,-0.018547392,-0.0469853,-0.010089989,0.033031832,-0.02829819,-3.110404e-08,0.043002974,0.0165859,0.09549038,-0.005502355,0.025684888,0.06658451,0.047328744,0.023877379,0.05470737,-0.01823385,0.06678718,0.1366357,-0.003378759,-0.007806513,0.06157595,0.025126383,-0.042780403,0.029086184,-0.04321274,-0.043715093,-0.06082395,-0.04526885,-0.09378262,0.11192094,0.062064238,-0.047225848,0.051934447,-0.03658658,-0.017439276,-0.027801774,0.03130554,0.020610426,-0.02822689,-0.047276534,-0.046758223,-0.050000776,-0.0007049086,-0.021966884,-0.07478082,0.049558423,-0.049685206,-0.10352974,-0.10910738,0.007892187,0.0008714433,0.09006068,0.0051724203,-0.015450387,-0.051627453,-0.0017914979,0.057736304,-0.09837581,-0.016877387,-0.002877935,-0.12708539,0.08117503,-0.06582949,-0.03986145,-0.023398979,0.0067772674,0.012117836,0.08295527,0.15277062,-0.0254292 +3.5.4.19,The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase).,384,1.0,-0.043166243,-0.010036571,-0.04855476,-0.056834485,0.051017262,0.04038208,-0.04858387,-0.00487053,0.042425446,0.02708931,0.028028613,-0.119039275,-0.057566024,-0.030027958,-0.064898916,-0.027975123,-0.08630783,-0.04835759,0.022445066,-0.09423602,0.042757113,-0.0108158495,-0.02449865,-0.017818257,0.01387019,0.017502084,0.00032516062,-0.001991896,-0.027662914,-0.064240456,0.021092996,-0.06682537,0.039172407,-0.05824699,0.0269262,0.09611933,-0.08456977,-0.07494039,0.032529477,0.071220204,0.021038089,0.012816972,-0.03497586,-0.00651866,-0.022209302,-0.012026121,0.0016855448,0.055550016,0.08339652,-0.07264901,-0.038578242,-0.051952526,0.038441233,0.036957175,0.041267477,0.069425344,-0.09580221,0.003427572,0.045349687,0.03597595,-0.010865009,0.013072741,0.02464087,0.026106536,0.029553985,-0.045427583,0.001682791,-0.08148898,-0.0029733982,0.051329836,-0.07103243,-0.046352316,-0.018712614,-0.020426258,-0.00023428025,0.042762913,-0.05192367,-0.07829778,-0.0054491833,-0.023646152,-0.03943373,-0.0043691094,-0.0057766703,0.0072605875,0.08328126,-0.019608978,0.037398078,-0.01461737,0.066003345,0.061084274,0.0186331,-0.08443433,0.009403727,-0.024607038,-0.07532944,0.103906445,0.0059136273,0.10130466,0.04486934,-0.050887793,-0.010842524,0.13509057,-0.0417497,-0.07529491,-0.029489893,0.09158518,0.031999152,0.13374564,0.028703166,0.050101977,-0.021697972,-0.065547295,0.023878638,-0.022961242,-0.009251105,0.11105792,0.03553835,-0.040625587,-0.052257787,-0.0013900241,0.025082037,-0.060286097,-0.051969457,0.053320803,-0.014580071,0.057679653,-0.15556052,2.4201612e-33,0.022793062,0.023239618,-0.056019325,-0.030110523,-0.0077486807,-0.016712308,-0.08906052,0.06811921,-0.029796705,-0.051188186,-0.05150796,0.005189609,0.0811532,-0.030771589,-0.09301696,0.0026352652,0.010372932,-0.020853192,0.03248209,0.007329821,0.008873413,-0.0065817065,-0.03276597,-0.016599257,0.010225549,-0.0020160084,-0.05334928,0.044966836,0.042821676,-0.005759971,-0.008462171,-0.06448331,-0.075450115,0.035336852,-0.005682995,-0.05677223,-0.0032049823,-0.06106049,-0.037775367,0.047500636,-0.023130987,0.04488816,-0.009486648,-0.059076175,0.034375075,-0.035373192,0.0019321905,0.071716234,0.15038066,0.01982694,0.024774916,-0.0018728315,0.14141281,-0.053824965,-0.0043901587,0.048995953,-0.03595902,0.0145053025,0.09664794,0.12238144,-0.019544875,0.06525721,-0.039098706,-0.007058501,0.07066602,0.049154542,-0.02424718,-0.059603684,0.032084424,0.01575482,-0.09720024,0.03534105,-0.022339856,0.0036720901,0.05945557,-0.04931638,-0.01539454,-0.038369615,-0.06808727,0.087303475,0.027660819,-0.0211053,0.05492459,-0.0062176962,-0.0008619136,0.027370058,-0.03880189,-0.020269278,0.025990091,0.017057916,0.020300467,-0.09696664,-0.018334039,-0.023194075,0.015839623,-2.0583902e-33,0.0484988,-0.08887223,0.008574791,-0.0818226,-0.07448013,0.12454947,0.0064564985,0.008646228,0.01285903,-0.014314974,0.03750082,-0.02423981,0.027079713,-0.0947972,-0.014688187,-0.033920147,-0.006703119,0.041986324,-0.014486308,-0.016878994,-0.015827985,0.14939374,0.025673492,0.033045225,0.040446073,0.027419044,0.0042256406,0.07914539,0.0029161354,0.033764184,-0.0417275,0.002411846,-0.050291836,0.0071299803,-0.021808181,0.019957352,-0.10037524,-0.00988886,0.07944535,0.04707836,0.0765184,0.04354733,0.08627776,0.026556822,0.0010924883,0.06692511,-0.08714171,0.117251866,-0.003356586,-0.053790692,-0.031495117,0.013771343,-0.043100424,0.005978958,0.09327507,0.044309966,0.02573772,-0.011097572,0.05756936,0.0035947328,-0.0014899927,-0.025502464,0.046089366,0.00093988434,0.00759258,0.073937185,-0.08645463,0.03824111,-0.00092185097,0.07623512,0.052728996,-0.0022190074,0.008428698,-0.01175575,-0.016166076,-0.0024748954,-0.042217694,0.0059115104,0.026483988,-0.03644343,0.063929826,0.03377214,-0.013664852,-0.067758925,0.011094977,0.0011814323,-0.040850595,0.03654416,-0.034046263,0.04253216,-0.009971832,-0.04403078,-0.008682838,0.08730869,0.06484066,-3.0894096e-08,0.09055808,-0.0015464225,0.09436778,-0.02949468,0.045492504,0.04759763,0.023060579,-0.04214132,0.018374125,0.021345321,0.01627704,-0.0007308091,0.08127534,0.00046979546,-0.00578592,0.04671729,0.0068765595,0.05332788,-0.010854082,0.022405664,0.018550921,-0.042508304,-0.08741095,0.07898233,0.065942384,-0.06760937,0.052466676,0.050700404,-0.03926211,-0.07710955,-0.06333737,0.013953838,0.0425497,-0.011832268,0.037829313,-0.002471397,-0.10547092,-0.021097744,-0.07796134,-0.008338705,0.004123618,-0.043774452,-0.018133905,-0.018311338,-0.07432745,0.056299977,0.0090082595,0.03127025,-0.0005824457,0.00448034,0.060452115,-0.064959496,0.056862235,-0.051835187,-0.08247619,-0.06790358,-0.022399612,-0.11300923,-0.00562074,-0.048567533,0.03737082,0.034830455,0.13289687,-0.010469963 +3.5.4.23,"Catalyses the deamination of the cytosine moiety of the antibiotics blasticidin S, cytomycin and acetylblasticidin S.",384,1.0,-0.08462284,-0.0007914661,-0.103789665,0.0018770389,0.011232323,0.037469998,0.008365902,0.054722384,0.07537577,0.0026093912,0.05964431,0.05209185,0.08331984,0.07973901,-0.06137946,-0.022093903,-0.06929935,0.031794194,0.005131837,-0.00018378255,0.0046461355,0.045728095,-0.024147421,0.054219056,0.07680914,0.068027735,0.008672783,0.09038746,-0.09203718,-0.043457914,0.10409846,0.0521322,0.0246315,-0.049688015,0.09793939,-0.021019382,-0.016644647,0.032198332,0.15604967,-0.04251863,-0.03636731,0.01025999,-0.008415125,-0.034088697,0.04420863,-0.03231213,-0.015773995,0.027818289,0.07267176,0.0011048751,0.022047268,0.035498466,-0.0023560668,0.05225438,0.055265468,0.015477444,-0.039550398,-0.032618728,0.013592403,-0.03280927,-0.039263252,-0.072124384,-0.003081499,0.030523667,-0.09052646,-0.029043946,0.06345966,-0.05621523,0.021539813,0.026904386,-0.036708612,-0.042651474,0.05537363,-0.0019797792,0.07815285,-0.039758436,0.038226712,-0.038531628,-0.091709666,-0.0016896925,0.042858984,-0.052184947,0.010275476,0.076779306,0.008150361,-0.034406945,0.073826715,0.008533105,0.04826971,0.10368262,0.027753927,0.076306626,0.07388544,-0.05574637,-0.032455705,-0.0748162,0.051577263,0.013871588,0.031871468,-0.011747959,-0.01754845,0.036746554,-0.035501644,-0.09551019,0.038869992,-0.0037315893,-0.010016772,0.075456016,0.030189283,-0.053619813,-0.006423725,-0.051814675,0.012383329,-0.064527564,-0.026493708,0.061094567,0.042669926,-0.029559048,-0.0717466,-0.055380076,-0.0057922467,-0.03611617,-0.042058334,0.0698351,-0.041259564,0.0325114,-0.03571341,1.6444178e-33,0.0019420463,0.083898835,-0.03617892,0.01854121,0.029591635,-0.04798612,-0.014632477,-0.03903193,0.017103251,-0.060172573,-0.12480843,-0.054812837,0.03144618,-0.0003674804,-0.080994144,0.005328855,-0.0028660833,-0.02474776,-0.028534818,0.00786339,0.03183678,0.049194373,-0.03556085,-0.056816462,0.027903305,0.012103156,0.009055534,0.073434204,0.05403878,-0.017485978,-0.0068628644,-0.022184413,-0.039365117,0.010040456,0.045935787,0.029979557,-0.029124372,-0.055055607,0.1198109,0.0579842,-0.080214895,-0.00040843122,-0.020001985,-0.06144808,0.011891837,0.02135019,-0.033317313,0.06264833,-0.050784256,0.044556774,0.10002817,-0.06013585,0.09370304,-0.013129117,-0.051745858,0.054009173,-0.042148605,-0.041315705,0.06189183,0.03210524,0.027223596,-0.048267305,-0.03791576,-0.010308781,0.033265114,0.03559494,-0.02320317,0.012313848,-0.030784348,0.012935773,-0.048147637,0.04680876,0.094855696,0.015575069,0.085222535,0.07684863,-0.049609244,0.04844135,0.083235055,0.105312355,-0.035137698,0.014454144,-0.06883456,-0.010980667,0.040438563,-0.0074029956,-0.0029293622,-0.036509115,0.0043888087,0.04375726,-0.03532603,-0.14165722,-0.048610553,-0.019274369,0.013092498,-3.9577745e-33,0.12743638,-0.028106675,-0.0050176685,-0.017035915,-0.051494006,0.050195582,0.0072141048,0.022579094,-0.002688096,0.032875232,0.054685883,-0.018286113,-0.07018323,-0.059322562,-0.05504727,-0.069053434,0.032633226,0.027126059,-0.05056205,0.011415103,-0.040525187,-0.042167533,-0.05361304,-0.015748983,0.025878638,-0.03323422,-0.04461734,0.012291001,0.06276957,0.045431048,0.030924616,-0.06768509,-0.06168865,-0.06599138,0.015834149,0.17716435,-0.00820495,-0.027603636,-0.038826935,-0.06888826,-0.061667524,-0.024413161,-0.027814467,0.07130417,0.059242826,0.043703496,-0.03428325,0.05389992,-0.015680853,-0.0189394,0.013997041,0.05840159,0.022182597,-0.00096135976,0.0076198955,-0.0031858399,0.07543642,-0.0042349123,0.060709808,-0.045867305,-0.020038866,-0.011971752,-0.043019142,0.04867399,-0.04464934,0.014465375,-0.050603062,0.016725512,0.03484303,-0.097560704,-0.015472464,-0.01466524,0.061094295,-0.041921172,-0.022873038,0.007328888,-0.023705304,-0.086182505,0.022336565,-0.0048903823,0.07411697,-0.0746138,-0.0052937237,-0.020429825,-0.104031056,0.0009400478,0.06501736,0.034065273,-0.052504227,-0.07212099,0.017572919,0.0198766,-0.0015532413,0.03737548,0.019131197,-2.9082297e-08,0.06723002,-0.019936427,0.041690785,-0.10055499,0.0071824957,0.0614932,-0.0040043946,0.021955157,0.018256668,-0.107913986,-0.03178636,0.054921065,-0.029733466,-0.013554695,-0.03191792,0.027061773,-0.06021614,-0.027604984,0.031780615,0.029160792,-0.07459619,0.012908865,-0.1470783,0.04231349,0.015359597,-0.0041632866,0.055603474,-0.06271787,-0.07792778,-0.0038341875,0.083773814,-0.009032967,-0.05361525,-0.004244706,-0.03148687,-0.053202406,-0.075952336,-0.06663692,0.085344866,-0.03798285,-0.03168675,0.010088177,-0.10461594,-0.025373863,-0.051463682,0.017254882,-0.0054283594,0.037786163,-0.09109223,0.007442372,0.042022612,-0.044965714,-0.042757608,-0.06655156,0.021009967,0.03843262,0.09221066,-0.09785679,-0.012402054,-0.022728588,-0.03301298,-0.031051278,0.13165149,0.026451318 +3.5.4.24,"Also acts on isosepiapterin, but more slowly.",384,1.0,0.052390497,-0.15384169,-0.0064345025,0.078677654,-0.047850613,-0.03921899,-0.00030355636,0.017611846,0.05972387,-0.0238022,0.074527115,-0.005900842,-0.10464469,0.09026533,0.019512478,0.015169797,0.017194204,0.030829078,-0.009780805,-0.02345679,-0.0034523779,-0.0021738093,0.017513162,-0.03367358,-0.032690983,-0.04116392,-0.050671723,-0.063052595,0.072664954,-0.029492918,-0.07685395,-0.06774944,0.009733401,-0.0025857396,-0.027950026,0.09963961,-0.05746969,0.012663517,0.019735904,-0.009354815,0.07498925,-0.07119172,-0.03605133,-0.008338081,-0.023984758,-0.03441554,-0.028646417,0.00031587417,0.017664425,0.025666624,-0.045150395,-0.09933727,-0.03438951,0.027755925,-0.06682567,-0.040720217,-0.077773616,0.049604356,0.06635924,-0.0027029747,-0.06720788,-0.0077246088,0.033571962,2.1525208e-05,0.086831704,0.011169021,0.055477932,-0.07077469,0.039212722,-0.013715506,0.04853915,0.013534961,-0.047601458,0.04706611,-0.024997866,-0.03587385,-0.057273906,-0.061535615,0.005705153,-0.022739328,0.027244246,0.10528552,0.003481842,0.056395188,0.00657159,-0.036595844,-0.025329124,-0.042424984,-0.11673522,0.027035994,0.05601717,0.021899257,-0.0342585,-0.032259278,0.029872686,-0.027934054,-0.0030302315,0.018395826,-0.12167624,0.0015369115,-0.08445884,0.036286496,-0.106400385,-0.015566077,-0.036896724,0.004352205,-0.0011358686,-0.09712353,-0.050383855,0.036691755,-0.013155961,-0.0010158863,0.013255515,0.03521544,0.009848293,0.11436342,-0.011967585,0.047192317,0.030284405,0.077808335,-0.009649455,-0.035677545,0.03905298,0.031852208,-0.015070454,0.06316459,0.0008653838,-1.6657866e-33,0.0036098901,-0.024356369,0.017406572,-0.017582856,9.5631534e-05,0.04610447,-0.003612076,0.0033708569,0.04202457,-0.034795884,-0.021239832,-0.1331209,0.026161492,0.06308622,-0.0051916908,-0.0322033,-0.029560078,0.041814744,0.030054934,-0.033012293,0.03172523,0.09148882,0.0006951268,-0.0042790165,-0.015595573,-0.021295452,-0.060328443,0.026124759,-0.00204927,-0.00062018656,0.0047520204,0.021605063,-0.07693111,-0.028991925,0.004185534,0.041534804,0.095299475,0.0028884492,-0.026470559,0.013566057,-0.014855783,0.017641103,-0.077954985,-0.08876602,0.0771303,-0.020372087,-0.045898616,0.016531996,0.01262845,0.043246478,0.046429526,0.0057918276,0.057864953,-0.097440064,-0.023637142,-0.022510597,0.038157385,-0.03309242,-0.037382416,0.05938375,0.04985105,0.026558695,0.016075328,0.014485085,-0.023789907,0.022131622,-0.098264925,-0.051619623,-0.06805929,-0.0099308025,-0.05436876,-0.046986826,0.082615435,-0.041314527,-0.016368177,-0.08882039,-0.05344757,-0.009048964,-0.045816615,-0.043553423,-0.026632095,-0.02882703,0.07365636,0.010891315,0.04987623,-0.007110932,-0.009717569,-0.020181702,0.0048345947,-0.033659797,0.07987195,0.017098876,-0.13070779,0.023452712,-0.022727128,-2.6148755e-34,0.042140096,-0.10429036,0.033808593,-0.013674091,-0.008418006,0.08495018,-0.060990196,0.11771387,0.031431787,-0.0048742564,0.07407887,-0.024856525,-0.06663848,0.005112326,-0.010823054,0.05471763,0.012320558,0.105543226,0.013124718,0.035953883,-0.05124947,0.066163875,0.046571843,0.0936893,0.06513588,0.026003916,0.07998842,0.05991565,-0.031242402,0.011613758,-0.023509575,0.034897957,-0.10853138,-0.09361919,-0.0060953447,0.06606654,-0.06530437,-0.006117869,-0.07664214,-0.09243167,0.016703174,-0.026668992,0.083193935,0.0697829,0.056408625,0.00035196022,0.04056225,-0.01443584,-0.0861341,0.041349888,0.025211515,-0.017812358,-0.007097241,0.058304485,0.050070032,0.033787638,-0.05007997,-0.061636496,-0.067120545,-0.004100178,-0.024053743,-0.00870952,1.5987898e-05,-0.021845752,0.16226539,0.03897955,-0.0556203,0.045908786,0.07781584,0.021942481,0.10354041,-0.046476543,-0.06033529,0.032001074,-0.05969593,-0.01005303,0.041300025,-0.041187428,-0.0019472999,-0.05582342,-0.10015725,-0.014412469,0.016344637,-0.037693806,-0.049312826,0.055141088,-0.050257478,0.011412934,-0.011133485,0.12923987,-0.012360331,-0.031004388,0.018038867,-0.020620111,0.02219908,-2.0037659e-08,0.059293307,-0.041053187,0.07838649,-0.0052182167,0.015886083,0.0064204494,0.02032596,0.062027127,-0.0711933,-0.033253595,0.013181738,0.063639686,0.12130165,0.021842215,0.09896098,-0.014385244,0.046366837,0.0907406,-0.045806296,-0.007679424,-0.100443244,-0.05246416,0.028111039,-0.015650295,-0.06237079,-0.07628151,0.07622694,0.10541447,0.033923067,-0.045275237,0.052217506,-0.07592764,-0.013426625,-0.0029306235,-0.009134689,0.07590092,0.06999149,-0.05159794,-0.0022322936,0.011907676,-0.06508709,-0.01280641,-0.0096335085,0.018119462,0.016245095,-0.019940896,0.020072326,-0.05316025,0.08781382,-0.005592806,0.05408459,0.00037173688,-0.027457202,-0.01912449,-0.037954714,0.046499588,-0.031921368,-0.0011715649,0.0146624185,-0.015845148,0.085387,-0.0147230355,0.1100046,0.023042755 +3.5.4.25,"The enzyme, found in prokaryotes and some eukaryotes, hydrolytically cleaves the C-N bond at positions 8 and 9 of GTP guanine, followed by a subsequent hydrolytic attack at the base, which liberates formate, and cleavage of the alpha-beta phosphodiester bond of the triphosphate to form diphosphate. The enzyme continues with a slow cleavage of the diphosphate to form two phosphate ions. The enzyme requires zinc and magnesium ions for the cleavage reactions at the GTP guanine and triphosphate sites, respectively. It is one of the enzymes required for flavin biosynthesis in many bacterial species, lower eukaryotes, and plants. cf. EC 3.5.4.16, GTP cyclohydrolase I, EC 3.5.4.29, GTP cyclohydrolase IIa, and EC 3.5.4.39, GTP cyclohydrolase IV.",384,1.0,-0.14617953,-0.056874543,-0.0858697,-0.0005768993,0.072364144,-0.02080486,-0.020338269,0.049684074,0.006919004,-0.03633489,0.007759471,-0.009854954,-0.040844314,0.059968047,-0.05527287,-0.012239557,-0.060562097,0.009564735,0.052047655,0.00488236,0.058211308,0.04000207,0.00025371183,0.022955889,-0.023617508,-0.018751899,0.057142984,-0.058671698,0.023176307,-0.016000874,-0.04596217,-0.017826503,0.0845209,-0.04659831,0.032693155,0.15102127,0.0071570044,-0.08593847,0.010582528,-0.009004927,0.06917926,0.028122228,0.060013317,-0.0583938,0.017314315,0.029600188,0.08544301,0.045645177,-0.037373837,0.05180964,-0.04353541,-0.038774893,-0.018186856,-0.009580101,0.02558749,-0.02046315,-0.113218665,-0.035505928,-0.020522146,0.019295879,0.0009271236,0.02160135,-0.049601268,-0.007785579,0.055722453,-0.056271963,0.013920949,-0.048651576,0.02021058,0.015212344,-0.023282932,-0.014081401,-0.056225453,0.020235723,-0.10215659,0.11655854,0.054253794,0.0053911284,0.0043109767,-0.03391953,0.081571154,-0.017368587,0.047706913,0.054501966,0.04885315,-0.06006969,-0.033432383,0.1099008,0.023353515,0.07272936,0.108724974,0.08542179,0.046816945,-0.024650542,-0.054665122,0.10537071,-0.0066364924,-0.012166124,-0.014471343,-0.0068586953,0.0018218583,0.049178768,0.10220098,-0.031781264,-0.026824482,-0.010105651,-0.021970078,0.06202541,0.028156945,0.043398228,0.0019201832,0.0141135715,0.037054352,-0.035350323,-0.04512591,0.11116039,-0.05431732,-0.05970025,-0.08084405,0.05579861,0.00048687623,-0.023213299,0.003195756,0.073034965,-0.012778133,0.05100087,-0.15590696,4.121419e-33,0.045683786,0.009119568,-0.008850408,-0.04103436,-0.041577782,0.03302502,-0.02412394,-0.003461383,-0.04430865,-0.04717331,-0.037528228,-0.07367588,0.08801479,-0.04227857,-0.044997096,0.027882153,-0.008973334,-0.014783145,0.050576396,0.021618672,0.028281698,-0.029800836,-0.042062186,0.02439757,0.016242227,0.045548007,-0.03523855,-0.037570998,0.04300861,-0.024013665,0.049684484,-0.15278147,-0.07361984,0.027245093,0.12387829,-0.060232,-0.031733077,-0.08892068,-0.03857177,0.012159867,-0.048212998,-0.043594245,-0.048417754,0.03963946,0.08245624,-0.07658494,-0.054098025,0.049212106,0.033672128,0.036394265,0.10194384,0.0133903595,0.05355851,0.031083465,-0.08756811,0.067987055,-0.022333637,-0.01885241,0.016626084,-0.0004908286,0.03144619,0.030294824,-0.035356738,0.026072238,0.026574919,0.051028967,-0.072008684,-0.09281222,0.025665432,0.08215611,-0.0058002844,-0.1201227,0.039139282,0.036425717,0.005925047,-0.040703245,0.0018610688,-0.008806713,0.04472986,0.028391736,-0.025048308,-0.0049034194,0.04630323,0.015010692,-0.0754383,-0.032757144,0.013980678,-0.05810403,-0.0017961639,-0.008029144,0.049453784,-0.09467664,-0.03203013,-0.008599188,-0.030064844,-4.107481e-33,0.070607856,-0.047332555,0.014534102,-0.063883394,-0.06155026,0.015294964,0.018819453,-0.107822835,0.023340903,-0.052620467,0.033825766,-0.037617497,0.03153459,-0.015898021,0.03457843,0.070892565,0.004987058,0.095350705,-0.008321483,-0.03307744,0.02577796,0.058559876,0.104790755,0.024065,0.006311809,-0.014240903,0.04670226,0.030295031,0.03325138,0.108525865,-0.089014105,0.059440657,-0.0925003,-0.06384989,-0.02753357,3.106742e-06,-0.01774249,-0.0012853727,0.046219032,-0.004815464,0.021567022,0.013812133,0.040387988,0.024443055,0.034953598,0.1027473,-0.028908439,0.03290218,-0.06880021,-0.020403773,0.007829895,0.05905664,-0.032996688,0.06283187,0.03457375,-0.018155953,0.03778862,0.056536112,0.0037590617,-0.032790348,0.01714319,-0.0924043,-0.010612781,-0.024838472,0.0579005,0.06304361,0.044397973,0.11231584,0.015778985,0.024421308,-0.013142966,0.023576913,0.08064446,0.031271737,-0.042068955,0.092920035,0.0025972496,-0.06589393,0.036906276,-0.09670342,0.025461089,0.07763856,0.010274752,-0.040158216,0.0065848157,-0.047339987,0.06449247,0.08845372,0.06440455,0.027449409,-0.0592376,-0.09263109,0.0036341278,0.014444191,0.052559346,-4.572771e-08,-0.03794875,-0.048349008,0.010060331,-0.07566226,0.03368587,0.07645859,-0.010103509,-0.02188566,0.023464167,-0.03343943,0.014449264,0.017245682,-0.007716155,-0.0039519006,0.041832957,-0.013037533,-0.03117591,0.047351018,-0.07174404,0.0014783182,-0.047859997,0.035334483,-0.11235083,0.055604193,0.01777375,-0.056532253,-0.020841824,0.0029552619,-0.012550172,-0.027472036,-0.0074999104,0.022943275,0.044890318,-0.061737757,-0.061308358,-0.010458598,-0.032220256,-0.02040355,-0.053116612,0.022212237,-0.0686734,-0.027093625,-0.018694118,0.0044757123,-0.028706787,-0.0316626,-0.022941139,0.050943784,0.016298477,0.04877746,0.026572272,-0.044362128,-0.047180578,-0.09058913,-0.039885577,-0.058704626,0.013657618,-0.07203399,-0.05546033,-0.03797201,-0.036263578,0.009752745,0.1439113,-0.051449332 +3.5.4.26,The substrate is the product of EC 3.5.4.25 GTP cyclohydrolase II.,384,1.0,-0.06432326,0.00030743182,-0.011551256,-0.0556251,0.08864626,-0.026664043,0.013688224,0.073604606,0.0056901453,-0.09873029,0.0637424,-0.07549885,0.011425847,0.05058565,-0.02573071,-0.01961229,-0.017286446,-0.05815935,0.046113305,-0.066744946,0.03741159,0.02760268,0.007947995,0.03840106,-0.0153204575,-0.0007504483,0.032537498,0.011823455,0.0067229783,-0.040022384,-0.020972712,0.031506535,0.063341536,-0.06045593,0.030392244,0.080849655,-0.068804525,-0.076285236,-0.01917068,0.010627705,0.06766476,-0.019203424,-0.009799019,-0.01831871,-0.025080372,0.032755878,0.013385216,0.006539242,0.0061293407,-0.044374924,0.039262395,-0.06548491,1.0687604e-05,0.0033128103,0.023028623,0.010755105,-0.10972627,0.02477664,-0.039397355,0.029118864,0.04373996,0.067818746,-0.036186226,-0.012649034,0.00040364743,0.00047245942,0.03276238,-0.11308095,-0.03949163,0.020136278,-0.11260659,-0.11156125,-0.011532261,0.019560162,0.032193393,0.047161084,-0.002547203,-0.094196245,0.04516042,-0.020042364,0.026350236,0.0457976,-0.045968417,0.047632407,0.043965086,-0.0065875533,0.073457085,-0.044415705,-0.021792796,-0.0004682384,0.042307068,-0.006313662,-0.052237004,0.011460719,-0.049903493,0.06483417,-0.014279808,0.047762558,0.043208383,0.0009812042,0.025926445,0.059120595,-0.0101595055,-0.04412702,-0.08080816,-0.022081258,-0.004554642,0.083214834,-0.021922937,0.00864881,-0.02142557,-0.055413138,-0.01775766,-0.036767196,-0.011904648,0.13567527,0.01021196,0.007387239,-0.009286277,0.011407206,0.03123306,0.0052934354,0.023977654,0.098022304,-0.049320932,0.0421764,-0.058467947,-1.0761104e-33,-0.011906798,0.01667753,0.019389786,-0.021407798,-0.056143124,0.0336693,-0.052348346,-0.008112521,-0.06093715,-0.064484484,-0.047698002,-0.04017234,0.032128535,0.018283471,-0.044077154,-0.06267593,-0.068878956,0.053396117,0.011464061,0.0019302835,-0.011058152,0.012405,-0.05503219,-0.0035630977,0.041011076,-0.0006864993,-0.059540775,-0.066161826,0.11942564,0.010297718,-0.009763492,-0.058210608,-0.07530753,-0.02616056,-0.016261982,-0.014251093,-0.043765783,-0.07096909,0.016000066,0.056168202,-0.012117089,0.022489866,0.108743384,-0.05169751,0.044974085,-0.015792102,-0.053596083,0.06022644,0.019011378,0.0002753996,0.07059218,-0.047899235,0.07719283,-0.049256667,-0.010901537,0.048773013,-0.067573145,0.03247148,-0.007656041,0.055548176,-0.0043439926,0.15997268,-0.0723036,0.036376312,-0.035395704,0.082780406,-0.074398465,-0.05841526,-0.07354262,0.031784374,-0.036046978,-0.0024415972,0.12219343,0.051902864,0.07820231,-0.041590873,-0.09318677,0.00322047,0.03540375,0.05514411,-0.11056289,-0.0071906922,-0.022113543,-0.021639327,-0.08839047,-0.048586633,0.04467597,-0.013595121,0.033584956,0.09005168,0.008723207,-0.0796578,0.013274842,0.06920104,-0.039183818,-8.99226e-34,0.10855599,-0.06650443,0.08628837,-0.1119511,0.006555896,0.014301388,0.049321335,-0.025275275,0.022179099,0.00046679232,0.08805561,0.022198575,0.022103935,0.014371098,-0.006145222,-0.0013982283,-0.026396824,0.06326495,-0.027097197,0.036034167,0.02016959,0.018875558,0.09755716,0.07259019,0.05876196,-0.013461329,0.10148074,0.0465997,0.053741723,0.010226009,-0.095651515,0.013973498,-0.042141266,-0.013446124,-0.039535277,0.03216626,0.044843897,-0.07760822,-0.042087708,-0.08295216,-0.017624853,0.084152006,-0.0262785,0.06269919,0.017731896,0.13857025,0.053046554,0.022523325,0.0099196825,-0.02504585,-0.0026545948,0.021006536,-0.028928347,0.045902245,-0.017724747,0.074967206,0.05143744,0.061567847,-0.0026423137,-0.042604525,-0.032485835,0.0040442315,-0.0054484447,-0.049444027,0.052681893,0.023687793,-0.0045455187,0.06909858,0.004735581,-0.00901455,0.056582075,0.018011978,0.013870066,-0.036596388,-0.04963676,-0.002690221,-0.0126215145,-0.019075477,0.029109448,-0.064787775,0.042822666,0.009294813,-0.0023787457,0.004338394,0.00049907714,-0.07952649,0.021897053,0.09175265,0.0020727895,0.012562267,-0.048582707,0.0007615892,-0.098863296,0.09676445,0.08391447,-2.6492335e-08,0.06532264,-0.06998415,0.010307372,-0.1340875,0.028531488,0.054856114,0.027693106,-0.010786784,0.068836965,-0.037026487,-0.01770133,0.042345535,-0.0065612295,-0.019070067,0.049553744,-0.0037892594,-0.09118734,0.0139926085,0.018908327,-0.024126528,-0.051262062,-0.0340421,-0.059968065,-0.016309496,-0.06590603,-0.06458701,0.07151434,0.052489817,-0.060487628,-0.033590287,0.009378756,0.030349793,-0.024144607,0.064246185,0.03582585,-0.005667328,-0.088250846,-0.0015573899,-0.042244434,0.06725959,-0.031951834,-0.08168238,-0.012115791,-0.033792756,0.068172745,0.014433348,-0.0079356255,0.011089901,-0.009498574,0.025147572,0.010278135,-0.08455964,0.028081968,-0.04947443,-0.01375592,-0.043051146,-0.047983147,-0.09783981,-0.04388015,-0.049019393,-0.042814337,0.022731105,0.21984291,0.019970488 +3.5.4.27,Methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum.,384,1.0,-0.050303645,-0.029663276,-0.15872449,0.023670226,0.03070147,0.025281789,-0.064601354,0.074160896,0.04680024,0.0023225832,-0.016272807,-0.12543137,-0.13247564,-0.031247417,0.0048108203,0.048568506,-0.036639914,-0.056502905,0.051851697,-0.044955846,0.0074756187,0.08888199,-0.030240517,0.004973647,-0.010469127,-0.014013764,0.018716153,-0.000867488,0.010689428,0.09368277,-0.031553894,0.0074433815,0.025548099,0.0028946146,0.02324687,0.09478634,0.01438814,-0.037562843,0.078313336,0.00952691,0.06787918,0.001290749,0.07467649,-0.045188803,0.011475767,0.006737271,-0.020230629,0.0042720814,0.025804933,-0.10881463,-0.009441588,-0.037644107,-0.043145068,-0.0029215098,0.078554355,0.035175323,-0.019174388,-0.0016516672,0.038487926,-0.073348835,0.0665599,-0.017169436,0.05612375,-0.02101058,0.068358995,-0.08063204,0.035826232,-0.08813593,0.104988135,-0.0538449,-0.08838836,0.049316842,-0.027819766,-0.043484624,-0.082082674,0.0007502176,-0.040848166,-0.030968266,0.088862285,-0.034357313,0.065301165,0.078974605,0.026964204,-0.0012712891,0.020105414,0.013370421,0.034116913,-0.016280532,0.030577868,-0.06048263,-0.020365862,-0.034685362,-0.03569771,0.018958593,-0.12993796,-0.06320256,0.140274,0.014920264,0.006359345,-0.009820321,-0.015627364,0.050352402,-0.15268095,-0.08827598,-0.10364198,-0.019165648,0.06317593,0.059782255,0.074168,0.06604339,-0.00046021014,0.0050082915,0.05254755,-0.010736906,0.04128333,0.046350308,-0.016053542,-0.050232977,0.04598099,0.03846112,-0.00050516514,-0.017471708,0.025511488,0.08407299,-0.005347133,-0.03873124,-0.034421496,2.1855693e-33,0.062612906,0.044765364,0.050363213,0.0076757385,0.05026302,-0.034127545,-0.090285026,-0.044936232,0.013275927,-0.018529862,-0.023183396,-0.054060854,0.017138807,0.030696552,-0.06273162,-0.025526464,-0.06286445,-0.028984819,-0.010900601,-0.0035353752,-0.029598407,0.071089916,-0.026353989,0.051423997,0.0055204434,0.022508066,-0.018548988,-0.027099757,0.05302921,-0.019850766,-0.021556094,-0.01627103,-0.17245191,0.07757452,0.0015919901,-0.013391983,-0.06728692,-0.05287969,-0.07316816,0.033752903,-0.0022874346,-0.026692456,0.02769032,-0.039206736,0.056572095,0.015877701,-0.026851421,0.06390746,0.040052123,-0.012357849,-0.05040594,0.012068886,0.016152197,-0.023031108,-0.080674,-0.038792655,0.032187626,-0.016609482,0.049286038,0.062361926,-0.043964885,0.0023680814,-0.0066581746,0.07544783,-0.06596055,0.03596389,-0.04799786,-0.09697031,0.11409859,0.106367655,-0.023620361,0.052311283,0.02350541,0.08624007,0.042919617,-0.0440055,0.013375771,-0.012322922,-0.019166099,0.022540763,0.008827211,-0.04490041,0.07641431,-0.05550757,-0.05755349,-0.01705817,-0.09942877,-0.045069113,-0.006072883,0.062624946,-0.025000239,-0.0055469577,-0.033761974,0.018669076,-0.0031754365,-3.6922263e-33,0.05550713,-0.024049642,0.010402483,-0.11381006,-0.050049633,0.04241134,-0.07660655,-0.08878907,0.016082944,-0.12954593,0.14138824,-0.056510143,0.059907448,0.011399959,0.08453347,0.049279418,-0.022685794,0.07498971,-0.001228103,-0.033334818,-0.004350134,-0.0444357,-0.0499985,-0.03398291,0.06210518,-0.034414824,-0.0004135222,0.0127223,0.06145472,0.025700742,-0.014105462,-0.0002634818,-0.106473036,-0.00855572,-0.0849083,0.033987075,-0.049447335,0.010924389,-0.00430258,0.016760524,0.042301,0.034632087,-0.009191996,0.05685828,-0.0021391176,-0.0029576025,-0.039190605,-0.030143127,0.009449743,0.022293365,0.035153486,-0.087363005,-0.04616115,-0.07780321,0.006317231,0.14378566,0.019820852,-0.0063442723,0.027311016,-0.02620609,0.035102718,-0.028372286,0.058492705,0.059134845,-0.013572727,0.050482,-0.01018941,0.053086653,0.09193899,0.05143383,0.10757436,0.062035367,0.032236215,0.06976143,-0.001204708,-0.06588899,-0.032631673,0.0076662926,0.029050019,-0.017095512,-0.012699531,0.025263635,0.08205788,-0.03144546,0.007967047,-0.0006169463,0.037266146,0.015999286,-0.055653304,0.061724346,-0.021322455,-0.02471407,-0.029359663,0.011056547,-0.0072815516,-2.9005639e-08,0.0736568,-0.08658488,0.033859573,-0.045645162,0.002443384,0.025433505,0.04880145,-0.022480505,-0.012794094,-0.01883005,-0.049560733,0.037338104,0.05021497,-0.01978177,-0.012716606,0.046145014,-0.033383217,-0.0424655,-0.03077981,-0.004095756,-0.028409598,-0.045481626,-0.048914254,0.03401192,-0.0018687906,-0.011066258,0.042114787,0.154028,0.02455091,-0.033202317,-0.03096249,0.027815016,0.0074400925,-0.047368057,-0.04527619,0.062470652,-0.0062075765,-0.056063592,-0.05518696,-0.018772751,0.022296846,0.013342833,0.012650971,0.0019177918,0.063738585,-0.025102794,-0.03977432,0.031409957,0.022497173,-0.0297067,0.06077193,0.021535493,0.0038415778,0.014329354,-0.054632213,0.007486728,-0.040969945,-0.00566424,-0.029787412,-0.015629264,0.017570931,0.024993552,0.12823187,-0.003864139 +3.5.4.29,"Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N7-methylguanosine 5'-triphosphate or inosine 5'-triphosphate. Xanthosine 5'-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC 3.5.4.25), this enzyme does not release formate, but does hydrolyse the diphosphate from GTP to phosphate.",384,1.0,-0.09251687,-0.03480929,-0.00010492176,-0.03349851,0.049705863,-0.0887526,0.016650483,0.025601992,-0.015921703,0.009148791,0.014562307,-0.014631378,-0.03319063,0.0496578,-0.05339895,-0.020383919,-0.0006142216,0.016088936,0.04242703,-0.06895268,0.15930836,0.0036527219,-0.030114667,0.0010083446,0.014239694,0.002951509,0.045727298,-0.011913812,0.030875152,-0.05078673,-0.088872045,-0.010911516,-0.0014261957,-0.08268819,0.08200873,0.14870884,-0.013772303,0.003883947,-0.027783416,-0.050748736,0.06315465,-0.033883322,0.036852345,-0.03791625,-0.0010672372,-0.06540215,0.088325344,0.022956228,-0.026500113,0.015284542,-0.038784746,-0.018361535,-0.047107562,-0.037768915,-0.0046457914,-0.024893485,-0.122428216,0.0104323095,-0.058224767,0.049464688,-0.01545591,0.06270294,-0.09332123,-0.033906516,0.018296445,-0.04946264,0.033435863,-0.031963192,-0.021146845,-0.011924387,-0.026109898,-0.024284303,-0.02308634,-0.011272699,-0.068331346,0.06948562,0.013136529,-0.03580716,0.027148707,0.014713181,0.056250606,-0.0040279976,0.047781162,0.02400872,0.08041506,-0.0228159,0.026349397,0.096504964,0.022198323,0.047888286,0.06509905,0.07696862,0.008410198,0.009749887,-0.026758384,0.07612463,-0.021313993,0.042130336,-0.022111569,-0.010820709,0.0423945,0.0629456,0.027312161,-0.054503806,-0.039502624,0.0141752465,-0.0056066755,0.06690475,0.007451852,0.01006034,-0.042551175,0.028494662,0.023609508,0.041798078,0.019224036,0.122547396,-0.039949186,-0.029060092,-0.07626697,0.0077573657,-0.0054068714,-0.01817912,-0.026409473,0.059895877,-0.059088506,0.06479017,-0.011817923,5.4366077e-33,-0.022005416,0.029577106,0.030574808,-0.06015752,-0.059241805,0.075175494,-0.07080598,-0.0012734947,-0.07028265,0.034626815,-0.009272086,-0.047590487,0.030184533,0.0034026918,-0.048933115,-0.010748902,-0.012914279,0.09163699,0.078558825,0.040088948,0.0027197849,0.054579917,-0.0663794,-0.0180881,0.00093185727,0.0994807,-0.0527816,-0.068324216,0.07323444,-0.011382352,-0.015196995,-0.10940293,-0.08094484,0.048194993,0.023067132,-0.026846008,-0.009130474,-0.059223097,0.0024075282,0.03723974,-0.08715597,0.0034982692,-0.012549173,-0.012042885,0.006417559,-0.035615537,-0.015918378,0.016264744,-0.0023540056,0.021698724,0.07972948,-0.0056541637,0.035937164,0.03760843,-0.03208835,0.045474153,-0.011150748,0.025930637,0.06104478,-0.0013546833,0.043465555,0.029462242,-0.04339568,-0.0451388,0.006654764,0.0072297407,-0.08779716,-0.084204815,0.017076075,0.10950797,-0.036679726,-0.05713273,0.047558706,0.056100283,0.046936266,-0.09124576,-0.0139668975,0.014108858,0.047981117,0.044539344,-0.0041539706,-0.016513254,0.019595057,-0.03392842,-0.06617261,0.061260644,0.027683904,-0.003097819,0.025575899,0.043279503,0.03845072,-0.081928335,-0.033538755,0.026881373,-0.006126364,-5.1856977e-33,0.10577653,-0.032421347,0.0056640003,-0.08772055,-0.08937665,-0.002054288,0.08039273,-0.10790938,0.025114711,-0.07807809,0.03789544,-0.045249093,0.00077636197,-0.018649334,-0.060767695,-0.033645682,0.023195075,0.068437256,-0.0053865677,-0.054185502,0.018134968,0.1109839,0.08990249,0.06838429,0.034123346,-0.0135990875,0.025992582,0.028431028,0.05351157,0.096003376,-0.07641724,0.03285673,-0.051267117,-0.0722953,-0.033636812,0.01821628,-0.032277845,0.0029694166,0.021003127,0.018589413,-0.0055465233,0.1083453,0.048137587,0.0716139,-0.0033028952,0.11503045,-0.020357812,0.033327334,-0.003851735,-0.050927337,0.016976051,0.03107276,-0.08314044,0.009345269,0.028615203,0.00020863228,-0.0055880244,-0.010704044,-0.07088721,-0.013650164,-0.03681964,-0.059459526,-0.014496467,-0.10695284,0.0788111,0.081979915,0.01830061,0.060976967,-0.008688877,0.06606707,-0.019338116,-0.034686834,0.038985763,0.0054443516,0.014114049,0.061942395,-0.031261113,-0.009127224,0.032924026,-0.14367595,0.057810076,0.07845088,-0.041012503,-0.08853127,-0.012310889,-0.072612695,0.032649674,0.11047804,0.07980476,0.025495574,-0.02131678,-0.009215579,-0.006197168,0.0898672,0.037423555,-4.420034e-08,-0.0080075655,-0.08169008,0.06639375,-0.0831654,-0.051694643,0.0888323,0.010892457,-0.019487567,0.1534927,-0.035678905,0.013525268,-0.016449159,-0.0033378433,0.01890191,0.03081793,0.021701738,-0.014067457,0.05855865,-0.03033244,-0.082257755,-0.059790865,-0.038847897,-0.15686716,0.046626765,0.012749732,-0.0372855,0.014963854,0.019882824,-0.014091713,-0.0071845143,-0.017625922,0.011803251,0.046108335,0.01901196,0.019995745,0.058029678,-0.04688799,0.034135412,-0.041695345,-0.08274572,-0.056623958,-0.03010837,-0.012572489,-0.027931485,-0.022041397,-0.012695614,0.009267897,0.019314623,0.0030339719,0.07908584,0.019512773,-0.037855387,0.004077822,-0.10435972,0.0060152737,-0.042068455,-0.002480339,-0.045930807,-0.027853964,-0.08436352,-0.0130882,-0.0028991979,0.14339428,-0.063143216 +3.5.4.30,"Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13, dCTP deaminase and EC 3.6.1.23, dUTP diphosphatase), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly.",384,1.0,-0.14324886,-0.036796853,-0.03056274,-0.031657252,0.055870906,-0.06432781,-0.08186843,0.053901542,-0.036609657,-0.0176249,-0.014148606,-0.011825681,-0.056371342,0.039654136,-0.028212186,-0.0011168441,0.016411245,0.054051545,0.04218646,0.06912189,0.07034802,0.024658535,-0.14047702,-0.05770754,0.0314122,0.011568084,0.030162426,-0.05915676,-0.028152894,-0.012200004,-0.013640033,-0.027858026,0.00895525,-0.0647979,0.082354814,0.085874476,-0.0654732,-0.040053032,0.06840394,-0.002650089,0.065750174,0.043990277,0.112705156,-0.040226895,0.0028837712,-0.052909743,-0.032958694,0.01803212,0.04778203,-0.051132694,-0.00056521234,0.010822052,-0.0006433646,0.05015089,0.021711119,0.0075099273,-0.12689656,-0.053443152,-0.024301209,-0.0057098228,-0.0141188875,0.043818634,0.0011192961,-0.04939911,0.116525784,-0.055854857,0.039158538,-0.05642768,0.1414598,-0.025924351,-0.07658079,0.0022591685,-0.043317147,0.027787894,-0.0072480557,0.06802477,0.054142322,-0.069504045,0.048030823,-0.057603974,0.028680814,0.038738355,0.036324203,0.014454573,0.030217301,0.0008656755,0.010266618,0.0666179,-0.012293546,-0.016194686,0.022374561,0.05826807,-0.0372898,-0.017058168,-0.07338257,-0.04343629,0.0047590104,0.07669845,-0.047734287,-0.0055256635,-0.0033910465,0.12551752,-0.02508248,-0.07076952,-0.06928777,-0.07780619,0.038295675,0.04441084,0.05156338,0.030283552,0.078558646,0.045163415,0.02675649,-0.008278283,0.0059251976,0.031662297,-0.028295608,-0.10658903,-0.066467926,-0.006307024,-0.08490205,-0.09094269,0.027047949,-0.034049474,-0.036030285,0.023449672,-0.019146701,3.758734e-33,-0.03198142,-0.01139132,0.01571329,-0.040159825,-0.023775032,-0.005003571,-0.042776015,-0.03047653,0.04819844,-0.047958735,-0.08848221,-0.030498082,-0.014562361,0.09110856,-0.10491842,-0.017585862,0.05443318,-0.013354791,0.08152836,0.0059380867,0.031502392,0.10581295,-0.016471822,-0.0075921244,0.09596462,0.01089441,-0.008249728,0.006848924,0.043419786,0.026922105,0.039391764,-0.065521754,-0.07860281,0.06932568,0.089693055,0.067131765,-0.0680991,-0.055307962,-0.03857135,-0.028079389,-0.039723884,0.05123536,-0.04368843,-0.021041177,0.034723997,-0.06860036,-0.058990568,0.045676332,0.0023682998,0.0042626457,0.025224585,0.009958302,0.008028736,-0.020042498,-0.05048039,-0.05743349,-0.030207288,-0.05028107,0.14371611,0.08810154,-0.0024727175,0.07645846,-0.13501683,0.051340926,0.04000578,0.05914859,-0.07913328,-0.02935497,0.055912245,0.06495339,0.0146931205,-0.06656837,-0.028631378,0.03247118,-0.009931519,-0.031507317,-0.0008100477,0.049347945,0.057110716,0.028144341,0.014014931,-0.049519006,0.001271933,-0.0035336283,-0.023141222,0.021502936,-0.01640837,0.018650567,-0.011391902,0.0031731313,0.08447119,-1.0167271e-05,-0.028649453,0.023776151,0.013539208,-5.10583e-33,0.08104532,-0.06779829,-0.040201586,-0.12129904,-0.08076112,0.07546406,0.009896105,-0.074639246,0.045928836,-0.07780834,0.057625517,0.012208926,0.016473664,-0.040293027,0.027982613,-0.048316963,-0.029299125,-0.0030803033,-0.03862024,0.0029305688,0.02769051,0.12524144,0.004847255,0.04641585,0.041485555,-0.027658546,-0.06812159,0.06991795,0.0051724464,0.011125091,0.010708405,0.1337603,-0.04083132,-0.057392612,-0.06895189,0.00468204,-0.038797423,0.013378337,0.016636942,0.036251932,0.03817398,0.038028043,-0.016693998,0.09171834,0.03869983,0.06320467,-0.05285051,-0.0046048067,0.042965557,-0.010755201,0.02057148,-0.05509264,-0.017378103,-0.040338464,0.02578457,0.06301287,0.04039844,0.017506812,0.054320917,-0.039535355,0.005106397,-0.06636203,-0.023833312,-0.049443185,0.01594856,0.060858957,0.041625023,0.05347267,-0.008732535,-0.0070538362,0.028086066,0.063236564,0.06263317,-0.047873862,-0.09838066,0.010921534,-0.082280844,0.024955058,0.084492154,-0.041851398,-0.03162771,-0.028381322,0.046715017,-0.012833856,0.013989153,-0.071079254,-0.009082823,-0.018349122,-0.027052425,0.021892652,-0.083499886,-0.06622921,-0.032781046,0.052266136,-0.032053757,-4.411095e-08,0.06704137,-0.003496466,0.024815144,-0.014660475,-0.07916679,0.037696645,0.009763155,0.04265758,0.09196462,0.011792389,0.052709125,0.061520543,-0.07974697,-0.04683598,0.018852765,0.023996139,-0.023167647,-0.004503535,-0.038516186,-0.022528369,-0.020690175,-0.059712946,-0.08553376,0.10877029,0.031609796,-0.008238058,0.10612905,0.044378567,-0.017391399,-0.0744823,0.0058494294,0.012740873,0.013513909,0.0004008588,-0.06522757,0.03875239,0.015717767,-0.042568542,-0.031575747,-0.009654273,0.014450013,0.022973638,-0.059171278,-0.01582051,0.0020693252,-0.019010376,0.05259648,0.040456846,-0.07465439,-0.033773005,0.0013476561,-0.06530908,0.014475684,-0.0053567863,-0.061074767,0.01339031,-0.026962772,-0.012046714,-0.063932106,-0.0036642442,0.051028293,0.034809027,0.13536833,-0.0038939686 +3.5.5.1,"Acts on a wide range of aromatic nitriles including (indol-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides. cf. EC 4.2.1.84 nitrile hydratase.",384,1.0,-0.063717924,-0.09984294,-0.029301021,-0.06809958,0.03144551,0.029233165,0.07152685,-0.06816826,0.08108155,-0.09713076,-0.0067138937,-0.046608116,-0.068067394,0.07672406,-0.06752579,-0.013542595,-0.06735394,-0.040753473,-0.0002624481,0.0066118278,-0.022240877,0.014675157,0.08377306,-0.042591814,0.008380503,0.0152921025,0.07062801,-0.033280157,-0.0027840203,-0.10539148,0.06071161,-0.0047937804,-0.04115221,-0.034725867,0.021499867,0.02955602,-0.07198345,0.040240508,0.031111032,-0.00091392413,0.08128227,-0.069256596,-0.0054272274,-0.04263217,0.025882099,-0.007894748,-0.004040866,-0.00614361,0.019672412,-0.020220848,-0.00576168,-0.03687183,0.009283671,0.034592945,0.012297846,-0.030349948,-0.08138374,-0.011371221,-0.021273488,0.02288938,0.07609901,0.03778489,-0.0263176,-0.0635708,-0.023758031,0.072281584,0.05485782,-0.024036195,0.045665782,-0.013502642,-0.056993436,-0.038374502,-0.03838084,0.034119025,-0.0037679144,-0.035487104,0.022112329,-0.018016478,2.7103797e-06,-0.09152514,-0.01873458,0.05814571,0.07714734,0.061480403,0.053001303,0.021043746,-0.054404736,0.027704788,0.056581628,-0.002448051,-0.009642025,0.029574983,-0.025647445,-0.050087687,-0.010443235,0.004756924,-0.0058612516,0.05854521,-0.03207061,0.043806273,0.03895178,0.06552694,-0.13260978,-0.028138738,-0.09160998,0.042537786,0.04348158,0.012643654,0.0035033177,0.03756632,-0.0514555,-0.06011193,-0.0037873252,-0.037185043,-0.11455873,0.015953239,-0.056780115,-0.017454691,-0.11478183,-0.017710803,-0.048159603,0.020332506,-0.008690472,0.06706186,-0.050741464,0.08286441,-0.015999135,2.0130062e-33,0.084573925,0.0043142093,0.006105557,0.025475726,0.0027878773,-0.0253702,-0.076918766,-0.042255975,-0.0105204275,-0.10790197,0.01770452,-0.052457288,0.009311537,-0.069004275,0.049060978,0.0067871255,-0.020213172,0.016787007,-0.0022855764,-0.022321675,0.007213104,0.10197697,-0.09956419,0.030859038,-0.07914314,-0.024405241,-0.012744868,0.05428704,0.079233006,-0.018313808,0.053321164,-0.051758956,-0.017802179,0.065102465,0.024264008,0.036136772,-0.10388169,0.02093094,0.021424333,0.07619299,-0.03506117,0.09634464,0.009066796,0.019165661,-0.05552048,0.015703758,-0.007848446,0.1490543,0.067941144,-0.030135691,-0.03613819,-0.0051047564,0.05922709,-0.004826959,0.0027198582,0.08500442,-0.015303636,-0.020593222,0.055367813,-0.04079869,0.033088937,-0.098597124,-0.008717351,-0.030727062,-0.022403473,0.1086413,-0.07773968,-0.014588713,0.09396162,0.06742701,-0.07003721,0.048585236,0.073469035,0.06815459,0.071273595,0.0072902357,-0.012785308,-0.09401657,0.043853067,0.061052755,-0.006443849,-0.001684447,0.08551384,0.012216361,-0.021976821,-0.04522123,-0.014678772,-0.078380734,0.03841019,0.011137139,-0.011074793,-0.081294574,-0.08497789,-0.07733999,0.023729932,-2.8486462e-33,0.11450127,-0.028493538,-0.060094547,-0.04923524,-0.0587526,0.039281633,-0.02789055,-0.026536634,-0.0008598692,0.09270291,0.08587514,0.02506532,0.03121427,-0.035913408,0.0032576923,-0.038737237,0.06715554,0.0030109552,0.00031580866,-0.045941938,-0.035671722,0.016038485,0.0031387147,0.011723855,0.0013739348,0.039103802,-0.0456673,0.002695777,0.06942795,0.01629321,-0.011619916,-0.033262372,-0.050854214,-0.020802746,0.061709847,0.02878728,0.054274708,-0.020756913,-0.11377421,0.008072121,0.06574975,-0.019231219,0.06452401,0.086944714,0.021053148,0.024264079,-0.109893315,0.044942275,-0.11587445,-0.11335203,0.042969104,0.005923703,0.015198301,0.014681914,0.02313316,0.07163969,0.0928725,-0.023792963,0.029322175,-0.04472464,-0.033411045,-0.016283004,0.022828007,-0.062972054,-0.066347755,-0.029732382,-0.061976336,0.074545965,0.11452855,-0.047521416,0.0040953774,-0.06625557,0.11048631,0.03789378,-0.054216735,-0.10841643,0.057807956,-0.09583702,0.040023677,-0.092675194,0.0466432,0.0011429177,-0.0013496387,-0.06694522,-0.029565016,0.008539799,0.060419284,0.08945154,-0.035607543,-0.009841483,0.032621387,0.039802104,-0.03757613,0.1036401,-0.039781075,-4.0013006e-08,0.03151582,-0.011011862,0.043507982,0.070464656,-0.055247582,0.03072571,0.03254684,0.033965826,0.019430883,-0.050101563,0.05057631,0.009576024,0.017083697,-0.045180757,0.033384163,0.018656997,-0.0007603019,0.013891848,-0.06789633,-0.055531863,-0.07680922,0.07205702,-0.07916538,-0.013896606,-0.012076348,-0.02045727,0.010570063,0.0007064301,-0.058342297,-0.046398852,0.003864369,-0.0052255304,0.0480547,-0.031597093,0.02708643,0.08255638,-0.030016873,0.00049812195,0.020405103,0.017898511,-0.012745564,-0.0067694252,-0.02939266,0.06439702,0.06752208,0.018637225,-0.017138949,0.016523689,0.00869577,0.014025432,-0.0074646627,-0.005064084,0.064067654,0.0013629813,-0.10497743,0.05942802,-0.030580891,-0.061634783,0.01938859,-0.018935554,0.034947764,0.023721978,0.049497418,0.055385046 +3.5.5.4,"L-Asparagine is formed as an intermediate. cf. EC 4.2.1.65, 3-cyanoalanine hydratase and EC 3.5.1.1, asparaginase.",384,0.99999994,-0.05237283,-0.10167741,-0.048539273,-0.011676499,0.02677705,0.07212177,-0.07271284,0.062371727,0.02500995,-0.06520018,0.080916725,-0.043957867,-0.03525451,0.0068539847,-0.08276582,-0.024988873,-0.015720844,-0.07625874,-0.08234749,-0.013823305,0.06674011,0.036790073,0.048333686,0.017515818,0.10346574,-0.063998535,-0.002180548,-0.05867526,0.048286736,-0.09559689,0.0044721607,-0.04102872,0.029044306,-0.005683529,0.07523584,-0.007418452,-0.020679276,-0.076214954,0.0811789,0.030743314,0.048916608,-0.04209574,-0.030316126,-0.00068450783,-0.033052985,0.022347627,-0.010647475,0.036238637,-0.00070961175,-0.04256461,-0.02159814,-0.046337906,-0.09423445,0.066109456,-0.10381161,0.028999014,-0.14836136,0.017657783,-0.012536654,0.022063509,-0.017522192,0.09293302,-0.0072507006,-0.032987684,0.018976439,-0.013187543,0.039769027,-0.031059796,0.06401247,0.06782386,-0.008361493,-0.06481863,0.033435646,0.09833777,0.0064195152,0.011360379,0.06373418,-0.0053217807,-0.06022793,-0.06828867,0.057423957,-0.039645873,0.011318583,0.07254242,-0.0030271239,-0.11440082,-0.021773882,0.069269426,0.03688784,0.005357602,-0.012964182,-0.006898933,-0.030287389,-0.020247413,0.022922508,0.053731333,0.049870364,0.016192084,0.05062806,-0.038862765,-0.042877253,0.066090584,-0.05070528,-0.07564209,0.06019518,0.0049367626,-0.02699458,0.023170324,0.043374754,-0.05113953,0.037224878,-0.08098171,-0.021286769,-0.034726426,-0.0616357,-0.015090647,0.03904427,-0.058968958,-0.06076477,-0.0050682067,0.03890508,-0.008490419,-0.004950478,0.074324965,0.025027426,0.060200624,-0.08911982,-1.8400487e-33,0.058094446,-0.024474883,0.056352377,-0.02428893,-0.047556054,0.09576989,-0.018045738,-0.025046019,-0.026941726,-0.123570964,-0.08417256,-0.082596175,0.004057933,-0.010779636,-0.0072436137,-0.05662802,-0.0063336664,0.002878331,-0.012244927,-0.04642904,0.015787864,0.10282562,-0.06372844,-0.00031037154,-0.026283203,-0.028378498,0.030084845,-0.010447282,0.035330154,-0.0041505964,-0.02875393,-0.060038242,-0.09424197,0.04122728,0.026532449,0.026878743,-0.064061545,-0.1104773,0.05256697,0.044121116,-0.036622353,0.045320377,0.05528595,-0.05469782,-0.041937303,-0.076262146,-0.07147848,0.04831463,0.10613445,0.015921703,-0.01597802,-0.020319771,0.08779921,-0.040292967,-0.022366446,-0.015736802,-0.09506248,0.04298605,0.023610314,0.032975096,0.04069711,-0.01254886,-0.05939007,0.040739205,0.0147725,0.06935594,-0.06700737,0.013610606,0.014007963,-0.002442384,-0.111499935,-0.08894329,0.098996826,-0.009014758,0.084338225,0.023602253,-0.0922497,0.034442034,-0.013099626,-0.034973122,-0.020268371,-0.0191144,0.027593734,0.106335334,0.019508546,-0.008743729,0.05600883,0.0017718215,0.099946074,0.016836472,-0.06553081,-0.06890884,-0.032448143,0.019498711,0.012239498,9.6766e-34,0.043341093,0.008268705,0.036901873,0.056008007,-0.0007719743,0.054897115,0.015073299,-0.03242917,-0.017631346,0.061648533,0.05622763,0.048447106,0.021199707,-0.07945315,-0.03292782,0.021912992,0.034853492,0.049689654,0.006551898,0.0044759857,0.0018418956,-0.0054641184,0.026013985,0.08896396,0.051213443,-0.012985096,0.018042883,-0.005552064,0.007562784,0.053798378,-0.005331533,0.030955382,0.012693568,-0.103762195,-0.06303657,-0.007148444,-0.0045468183,-0.05280495,-0.01449685,0.003463937,0.022010874,0.010536859,0.06489805,0.059406046,0.036476757,0.028030667,0.024645261,0.019558245,-0.063911624,-0.042784672,-0.0012783598,-0.00672579,0.026182301,0.038699042,-0.018591886,0.009087558,0.025796771,0.0604656,0.007906989,0.0071384627,0.049256697,-0.032868847,0.07425486,-0.11102901,0.047634937,-0.04242413,-0.063289285,0.0861078,-0.01893127,0.012150067,0.024976503,-0.058919128,0.086962916,0.017773185,0.023879614,-0.10322065,-0.014674254,-0.08696198,0.053915918,-0.054467093,-0.01579367,-0.024143633,0.015531302,0.012269335,-0.026167216,0.0114895385,0.056368805,0.14425774,-0.01482755,0.022326574,-0.012499404,-0.077210754,-0.0292217,0.13674037,0.10129314,-2.9127998e-08,0.09504055,0.06226186,0.019888394,-0.0059997854,0.06564662,0.07469973,0.000874633,0.08147399,0.029958665,0.006997137,0.025076352,-0.03721974,0.03471918,-0.06625099,-0.027229913,0.0035357196,-0.009515633,0.068700515,-0.022438413,0.08538993,-0.0676197,-0.0012263808,-0.09353004,-0.03374386,0.08088776,-0.0023638222,0.019431457,0.09215427,-0.017103245,-0.033145625,0.0407153,0.015493963,0.07580799,-0.052883297,-0.080952786,0.029947668,-0.017906705,-0.002924012,0.024059786,0.040617328,-0.04369112,0.005945167,0.030280009,0.055378094,-0.0054610167,0.023184942,0.04880603,0.041745488,-0.047900982,0.009081094,0.01323869,-0.05721064,0.00058775616,-0.07465928,-0.026148302,0.00046356046,-0.06431454,-0.043602005,-0.019676253,-0.08365892,0.004794803,0.008186385,0.11536645,0.043140706 +3.5.5.5,"Requires thiol compounds. Also hydrolyses other 4-substituted phenylacetonitriles, thien-2-ylacetonitrile, tolylacetonitriles, and, more slowly, benzyl cyanide.",384,1.0,-0.032350037,-0.037584692,0.029645577,-0.022152562,0.03847189,0.04364189,-0.029279076,0.03405857,-0.007175831,-0.008064731,0.013915768,-0.04715939,-0.10243652,0.11023473,0.0070506325,0.013759614,-0.057548154,0.116153315,-0.017034635,-0.040432394,-0.031575404,0.01997388,0.019391991,0.054364666,-0.02779068,0.0042246147,0.019962072,0.010257225,0.087308414,-0.03415279,-0.01404082,-0.023103407,0.030531064,-0.02665547,-0.0007599688,0.06528198,-0.03023456,-0.022578068,-0.038535595,-0.0049662986,0.020364754,-0.053815052,0.016421858,-0.015277498,0.029247496,-0.032742783,0.021046283,0.006643003,-0.005110012,-0.013425455,0.017178107,-0.016579742,-0.0022118068,0.0825169,-0.12619253,-0.030804368,-0.102081545,0.062099032,0.009934843,0.038343377,0.015417735,0.022034192,-0.05367197,0.0054053194,-0.07791572,0.028407754,-0.05320835,0.03519976,0.038457878,0.07773864,0.021337288,-0.03383455,-0.029353267,0.049997345,-0.024461333,0.010456005,0.040658176,-0.06861467,0.0007964719,-0.088560544,-0.014994029,0.0119525865,-0.017565595,0.06369811,0.079035275,0.018455422,-0.069507495,-0.0029512006,-0.010614528,-0.009149964,0.089631915,0.062389098,-0.04587373,-0.053376816,-0.032121543,0.037336554,0.10946015,-0.01670456,0.032473918,0.027260492,-0.0089247385,0.005923977,-0.029144742,-0.017077982,0.002126383,-0.019615596,0.051481187,-0.047856793,0.013629849,-0.013843926,-0.03235106,-0.03626729,-0.0006385088,-0.05328306,-0.019689074,-0.024598783,-0.010567739,-0.041013982,0.009943216,-0.03771591,-0.029895242,-0.023608211,0.032966014,0.024805991,-0.05792297,-0.017815981,-0.038340487,5.4935388e-33,0.0683668,0.061467372,0.024620343,0.029142682,0.014504426,0.01729618,-0.07643128,0.064375035,0.0069740694,-0.08313553,-0.02577698,-0.023695054,-0.02979547,-0.06508023,0.03138037,-0.11864828,-0.012577519,0.013989911,0.10537065,-0.041258544,-0.020443434,-0.016263595,-0.04792978,0.06377356,-0.017271224,-0.020927247,0.049190987,0.032139115,0.09529355,0.00945679,-0.016895888,-0.081251636,-0.005418406,-0.012936674,-0.033753317,0.060123757,-0.10567111,-0.02058686,0.028274748,0.024398316,-0.02666709,-0.008470333,0.0038038362,-0.06288647,0.015998693,-0.03730014,0.0062229424,0.09722152,-0.023653615,-0.011175414,0.043767147,-0.0029270365,-0.025274446,-0.02784543,-0.032365397,0.012457157,-7.9810474e-05,-0.0030443098,0.014620834,0.008114032,0.001924083,0.040360317,-0.012076125,0.0058965445,0.024472214,0.05851883,-0.054316748,-0.0385998,-0.04646254,-0.014178736,-0.086746335,-0.021702005,0.065751046,0.024260331,0.086694874,-0.034953523,0.033999085,-0.039040618,0.061613016,-0.007720953,-0.035223763,-0.042120215,-0.029280629,0.10277702,0.027997006,-0.051720474,0.02396273,0.027402075,0.04583523,0.022091972,-0.0021584108,-0.11437159,0.031676147,0.0026836595,0.0012213822,-5.743745e-33,0.048309725,-0.030276887,-0.0016747821,0.036198214,0.03922228,0.034568124,0.01648725,-0.07725289,0.027070094,-0.06435424,0.10525315,-0.04886481,-0.0124850515,-0.035463847,-0.047132846,0.06226433,0.02426284,0.028960405,-0.011900015,-0.012369306,0.021433443,0.0496446,-0.050497346,0.046023287,0.021159695,0.041533783,-0.047759492,0.02006576,0.023152621,0.1458387,-0.088771366,-0.0067051086,-0.075587876,-0.09726082,0.0003716165,0.060109463,0.003316881,0.016246142,-0.043101724,0.04532855,0.017991798,-0.036917895,0.05285474,0.1310785,0.031358797,0.08209049,-0.050434276,0.018516187,-0.035466593,0.013328779,0.05027253,-0.019869275,-0.12925644,0.015971424,0.019731803,0.02340629,-0.015951129,-0.026892016,-0.0064319917,-0.08825099,-0.080516644,-0.11912227,0.0379814,-0.08417267,-0.02657166,-0.02054286,-0.07920297,0.11290956,0.07618336,-0.08006593,0.059452392,0.010534124,0.12305689,-0.0056290342,-0.051196184,-0.024213413,0.01774664,-0.09282612,-0.020299658,-0.062192816,0.035462666,0.014689003,-0.004536899,-0.037187908,-0.031974025,-0.039004035,0.01836705,0.03599037,-0.03800102,0.026637565,0.0067565814,0.08035884,0.06413244,0.15584384,0.022472566,-3.9346794e-08,-0.008007502,-0.077175036,0.039666053,-0.06579918,0.016762622,0.046247333,0.03130189,0.100332454,0.02185591,-0.1210603,-0.0071191466,0.08540462,-0.007973237,-0.0021408007,0.049158916,0.030011414,-0.070623666,0.037741218,-0.056793433,-0.0387818,-0.09454537,0.02061601,-0.08908841,-0.018936625,-0.008511253,0.013491709,0.057809312,-0.049569335,0.010294709,-0.012874944,0.10966626,0.0072634225,-0.012280081,0.015376873,0.040200677,0.06710253,-0.03496334,-0.026487956,-0.080520935,-0.045382086,-0.033544343,0.053249348,-0.12282584,0.071776316,0.0528031,-0.06982583,-0.012999978,0.11240341,-0.048603956,0.033702314,-0.025924146,0.001389919,0.019086897,-0.055064246,0.01065006,0.0077947658,0.04275596,-0.011440998,-0.06648036,-0.050960276,-0.03183778,0.063447654,0.24660012,0.016219042 +3.5.5.6,Involved in the bacterial degradation of the herbicide bromoxynil. Highly specific.,384,1.0,-0.07109311,-0.032146905,-0.028266067,-0.026522988,0.07104381,0.049616087,-0.037846398,0.06164898,0.04340897,-0.013428781,0.011966092,0.04314065,0.09066137,0.021113494,-0.11681238,0.05813793,-0.06263009,0.010322643,-0.050406415,0.016354509,-0.016277123,0.053804945,-0.11151652,0.053537607,0.0052339262,0.058210246,-0.022259936,0.015854638,-0.063940525,-0.06399869,0.047874805,0.12157094,0.042472247,-0.062317196,0.030818965,0.11078918,-0.009952032,-0.06792154,0.17066745,-0.012708383,-0.050738003,0.024453338,-0.05453444,-0.025485717,0.037961643,0.034473553,0.007537497,0.03779453,0.081300266,0.004931132,-0.016195217,0.015723882,0.039263483,0.029793736,0.04208369,-0.05396205,-0.0069228904,-0.01699306,-0.023975424,0.04035205,-0.06117536,-0.026083143,-0.011571707,-0.015184137,-0.085511014,-0.052141085,0.018823968,-0.04837979,0.071108274,0.0488587,-0.048287444,-0.0634802,-0.03194779,0.059567016,-0.0019971034,-0.0070664505,0.0020515434,-0.13221641,0.014112989,-0.090885565,0.016913243,-0.04419587,0.02667655,0.06449361,0.066410266,-0.05164861,-0.015941128,-0.045469575,0.078421116,0.072422564,0.028173786,0.060252536,0.037944116,-0.074151285,0.018946398,0.03210185,0.04096609,0.0022298212,-0.0236623,0.0099540055,-0.044449072,-0.06761423,-0.07966052,-0.0632905,-0.03901287,-0.014851686,0.06957783,0.08086151,-0.013430805,-0.028338326,-0.036802918,-0.021984888,-0.020539796,-0.074547224,-0.027345937,0.05530717,0.13044822,-0.022200832,-0.0868048,-0.029163081,-0.051795863,-0.0073518995,0.011240778,-0.008858768,-0.06691028,0.030492594,-0.009755389,-2.1438242e-33,0.033443734,-0.06666473,-0.019371836,0.019749362,-0.002280596,-0.05093786,-0.0641549,-0.059879053,0.09312853,-0.10927402,-0.0019631833,-0.10809607,-0.09321083,-0.043514717,0.03013544,-0.002923778,-0.053976122,0.03505466,-4.2027605e-05,0.006882178,-0.030186519,0.0063808006,-0.09132888,-0.002780593,-0.042847514,-0.03794804,0.0366569,-0.022834636,-0.015092566,-0.006908241,0.052230816,0.0046538375,-0.07192324,-0.02553285,0.04313914,0.032895185,-0.020625576,0.0023772311,-0.020290658,0.071028285,-0.0040783724,0.028606122,-0.0071804193,0.016308222,-0.021461193,-0.019651005,-0.03322195,0.053509552,0.035029072,-0.008167993,0.022515802,-0.024833903,0.057918794,-0.058842275,0.0074872025,0.08241565,0.030787213,-0.025804222,0.06330204,0.015930992,0.004411532,0.04170778,-0.05511686,0.02643198,0.07910172,-0.04746565,0.0018252156,0.025421184,0.0033783598,0.034153163,-0.024091568,0.015661804,0.047234215,0.022016976,0.050300907,-0.016130472,-0.08592849,0.030995443,0.021343887,0.0012154776,0.0795631,-0.03380873,0.050312407,-0.047528498,-0.08677016,0.07683138,0.040669207,-0.061346684,0.022258207,0.014458949,0.06479142,-0.083594926,-0.016812949,0.0015232353,-0.061037056,2.1103983e-34,-0.003962452,-0.051390983,0.08439813,0.045426503,-0.14815393,0.07668997,-0.082215,0.052819055,0.05150436,0.041990615,0.06871607,0.06887904,-0.008088125,0.019377317,0.01471112,0.028608166,-0.014507631,-0.0078017646,-0.053840682,-0.028425246,-0.033279706,-0.03982011,-0.0010293655,0.025517212,-0.013867164,0.025386453,-0.056036267,0.043908875,0.12686892,0.016107548,0.041162904,-0.016253395,-0.007834967,0.019417243,0.024698738,-0.002467963,-0.014704534,0.0035575188,-0.06397674,-0.07013439,0.049885478,-0.0075725373,0.027185686,-0.007628448,0.019603383,-0.0030423994,-0.039891656,-0.013897897,0.03779117,-0.056533415,0.013166997,0.06509149,-0.005643629,-0.012449854,0.017197058,-0.032174654,0.022371968,0.018008227,0.028918691,0.02457965,0.0051414706,0.011708973,-0.02349485,0.07310062,0.04233658,0.092381716,-0.050299767,0.035280865,0.028464027,-0.018705577,-0.039859544,0.021343105,0.06971409,-0.02444601,-0.0037693414,-0.008871763,-0.03923779,-0.034850996,-0.027046822,0.022998387,0.052558806,-0.034167416,-0.059078462,-0.10422138,-0.059143912,-0.10052582,-0.09268303,0.09106574,0.038180172,0.0041469024,-0.029054858,-0.057616454,-0.042754915,0.017617892,0.031723898,-1.98256e-08,0.016541412,0.03979288,0.030613117,-0.01989534,0.026837494,0.015770223,-0.010531432,0.017425565,0.15440142,-0.058415238,-0.08806386,0.092397064,0.00912186,-0.009734438,-0.011041826,0.014764524,-0.050412435,-0.08036347,0.057610653,0.027352411,-0.06939695,-0.0037313472,-0.037539996,0.010155144,0.015504593,-0.03146449,0.05262259,0.09511161,0.015853705,-0.013417084,0.007844582,0.049780358,-0.04350179,-0.04072959,-0.0645596,0.009715593,-0.09539551,-0.051550154,0.008866759,0.13440555,-0.025950259,0.022222435,-0.10796777,0.0076377643,0.0783271,0.021202741,0.041904606,0.048918236,-0.058219504,-0.050101675,0.047937613,0.020892352,0.056646965,-0.0030242798,-0.07824889,0.052666847,0.05660377,-0.078379184,0.038145926,-0.09669915,-0.07420955,-0.006499918,0.12955979,0.07876444 +3.5.5.7,"Preferentially hydrolyses aliphatic nitriles, some of which are apparently not substrates for other known nitrilases (EC 3.5.5.1). Substrates include crotononitrile, acrylonitrile and glutaronitrile.",384,1.0,-0.017324159,-0.11799775,0.029404463,-0.034739573,-0.01712527,-0.020948673,0.064426176,-0.076747365,0.00043911545,-0.06919201,-0.01028157,-0.07543057,-0.03648746,0.0865523,-0.07609405,-0.01503796,-0.03858347,-0.09865665,0.01945979,0.0027028723,-0.012894528,0.0015684641,0.017321834,-0.022216888,0.040807575,0.03333634,-0.004778934,-0.043321434,0.059616074,-0.07898913,0.0070975,-0.026647925,-0.0037777259,-0.039006066,0.07546025,0.03595988,-0.07147277,0.001524054,-0.005994839,0.019466834,0.09209858,-0.04356095,-0.020810515,-0.0070751193,-0.008825745,-0.033261813,0.031894926,-0.04461797,-0.06067435,0.018035807,-0.016781524,-0.048620652,-0.01936727,0.057834815,0.036761038,-0.029201085,-0.03548341,0.0031658586,-0.021623623,0.05025309,0.022018036,0.03972981,-0.06744089,-0.0602042,-0.03180164,0.06320771,0.020896062,-0.013071187,0.04813647,0.01666951,-0.027075894,-0.07726027,-0.015576486,0.048304796,0.021714315,-0.026315149,0.079797566,-0.07706599,0.036580134,-0.009007335,-0.0035944693,0.06357381,0.077592075,0.11621738,0.028223615,-0.009090863,-0.06689393,0.023627656,0.006051981,-0.015730573,-0.040375423,-0.030194268,-0.00066734635,-0.023255434,0.0069864816,-0.007700775,-0.036268637,0.0039607263,-0.033864334,-0.010192292,0.041071117,0.02240981,-0.04564002,-0.008573338,-0.1287469,0.10242788,-0.001149349,0.04649175,0.05090241,0.012363417,-0.03533305,-0.00042896543,-0.009934554,-0.055453017,-0.081902444,-0.029346377,-0.03414266,-0.01560906,-0.0007017665,-0.014572617,-0.05151907,0.00041908099,0.02249617,0.025839902,-0.0921061,0.1094787,-0.045629967,3.6957708e-33,0.05258661,-0.031373106,-0.008179138,-0.04643355,-0.06013875,0.026971508,-0.087146714,0.039900012,-0.027292289,-0.14107351,0.049638513,-0.0211911,-0.064050205,0.010396,0.07315338,-0.030678423,-0.00050589675,0.037988693,0.049671818,0.039767813,-0.023928093,0.03556166,-0.12455684,0.0024896422,-0.039178994,0.00078584685,-0.04054863,0.0032426645,0.022787891,-0.03452643,0.04465585,0.013067132,-0.0017439845,0.03170123,0.004339739,0.03856069,-0.06824893,0.05438283,0.01674742,0.040323008,-0.058535967,0.08623648,0.048702676,-0.06963389,0.027303575,-0.033123866,-0.08207023,0.09368726,0.014459011,-0.01083154,0.039560415,0.013506461,0.062721804,0.00046358377,0.030133765,0.09224344,0.0033461512,0.016474314,0.09110228,-0.03156946,0.0031669429,0.007103868,-0.007843912,-0.027808,-0.004327241,0.1039072,-0.067059495,-0.02724068,-0.011198333,0.078466386,-0.08104161,0.062282257,0.061284754,-0.00036860158,0.060766652,-0.08521462,-0.03113914,0.008740526,-0.004269972,0.08857026,0.07447461,-0.050941873,0.02085735,-0.0232477,-0.12115013,0.017510727,0.03247323,0.0050117606,0.008539439,0.036286388,-0.009529499,-0.06627466,-0.069910355,-0.04199711,-0.063115604,-4.2182596e-33,0.12320834,-0.09841107,-0.024496,-0.057345245,-0.049949657,0.042735998,0.08343807,-0.07529106,-0.020990748,0.062343255,0.08392492,0.05409709,-0.002208814,-0.035856392,-0.009518371,-0.018945612,-0.009297692,0.074751675,0.09226719,-0.03242449,0.007867296,0.06953438,-0.07862398,0.014124125,0.06821579,-0.037027024,-0.013160723,0.031283617,0.08857532,-0.02051919,-0.062053747,0.0018634052,-0.017819183,-0.0794629,0.036420275,0.046087105,0.049236957,-0.015419445,-0.13542481,-0.028939893,0.05613089,0.06736228,0.1106283,0.17938246,-0.018037293,0.08783512,-0.12615179,0.010438282,-0.020808838,-0.00018428995,-0.012260142,0.0032507498,-0.06985204,0.002117527,0.005042255,0.057981294,0.035139777,0.029116891,0.03061403,-0.085491166,-0.0874501,0.027966226,-0.0055084173,-0.067417026,0.024035359,0.042479668,-0.08227665,0.06727585,0.04126866,-0.019547004,0.03277053,-0.021371812,0.10114055,-0.029093226,-0.015895419,0.026971458,-0.01308301,-0.018468333,-0.015178323,-0.045804568,0.12823667,0.022029314,-0.008014206,0.0155362915,0.016164722,-0.01919052,0.05615001,0.036539413,-0.05250803,0.041140694,0.034947395,-0.026590785,-0.015148877,0.048251413,-0.0017629521,-3.7450764e-08,0.050032724,-0.07954625,-0.017032515,-0.012051969,-0.06774282,0.0015988506,0.033936214,0.006765705,0.012989894,-0.032285184,0.010536515,0.004901139,-0.017937057,0.029684696,0.023981635,-0.008718275,-9.761866e-05,-0.043026343,-0.034920342,0.007304207,-0.10452702,0.06206281,-0.074999064,0.049449924,-0.10482117,0.0010420704,0.070718445,-0.0046554473,0.0031730896,-0.043616988,-0.033383448,0.037229255,0.039923392,-0.08119507,0.06619076,0.028914962,-0.029379342,-0.032224298,-0.049251076,-0.021168943,-0.0068684416,-0.06991262,0.033791468,0.0212096,0.053756855,-0.02150915,-0.04364566,0.017653598,0.049219184,0.058070663,0.040752407,-0.026325958,0.025702335,-0.04045135,-0.059583373,0.010407685,0.022641832,-0.10155118,-0.026837528,-0.0039887074,0.05960019,0.06348437,0.15216857,0.041049577 +3.5.5.8,The enzyme from Thiobacillus thioparus catalyses the first step in the degradation of thiocyanate.,384,0.99999994,-0.036220286,0.026667895,-0.08834072,-0.007467635,0.020384297,-0.014533051,-0.05859657,0.053593613,0.0028329468,0.02414445,-0.044372663,-0.05223182,0.043135446,-0.02522522,-0.010823186,0.016571214,-0.051277526,-0.011605933,-0.011864658,-0.001199932,0.074328326,0.06650463,-0.086389154,-0.046721153,0.056142844,0.021818297,0.060709152,-0.080738075,-0.05680949,-0.048161607,-0.045957074,-0.02238685,0.0644287,-0.03345598,0.032639623,0.10935848,-0.110065676,-0.028692316,0.11343339,-0.06935104,0.021275641,0.015632294,-0.056381427,-0.03348417,-0.06369794,0.04058108,0.07726717,0.036515556,0.010269935,-0.02853757,-0.026175885,-0.009503356,-0.036443893,0.08046197,-0.08323464,-0.018363591,-0.006273735,0.02935894,-0.043207992,0.029893868,0.037035458,0.0049505807,0.011441717,0.029098855,0.052358456,-0.058436256,-0.008794123,0.0077586398,-0.012404631,-0.020049218,-0.060878683,0.04801957,0.00510468,0.024848968,0.03266517,-0.014812349,0.028870802,0.010895034,0.02887406,-0.048527513,0.036961585,0.023322498,0.075660236,0.10375528,-0.011013956,0.05080522,-0.012933755,-0.019766428,0.061829776,0.01764979,0.1031749,0.07233543,0.033293787,-0.03973953,-0.019392869,0.016251657,-0.020672673,-0.00034139754,0.056888815,-0.020015648,0.01341475,0.013233448,-0.04973424,-0.06595229,-0.04238933,0.046274737,0.059299443,0.03258166,0.039882716,0.02439412,-0.009726778,-0.013536415,0.062148668,0.0018289753,-0.05574572,0.07198246,0.057255987,0.0043771355,-0.06745958,-0.03892534,-0.023752308,-0.009750466,0.05282591,-0.010297427,-0.052599672,0.006692871,-0.059533708,2.5660375e-33,0.03125165,0.018823873,0.001954986,-0.1325504,0.063223176,-0.066837445,-0.0020118656,0.012587475,0.0053440933,-0.009752091,-0.074381195,-0.14608018,-0.07883253,-0.05582301,-0.011530749,-0.027280247,-0.056558125,0.030604778,0.0033538472,0.003794923,-0.010363865,-0.017650437,-0.04631085,0.014103589,-0.0058412952,0.11842172,0.08043627,0.0875073,-0.06854667,-0.010939166,0.0014675348,-0.08966606,-0.09800633,-0.03274033,0.0372515,-0.015729427,-0.05061559,0.062884375,-0.04606158,0.0029489228,-0.007198099,0.047315337,-0.032520063,-0.073323674,0.003608713,-0.038155574,-0.003973044,0.14485464,0.011157108,-0.030639496,-0.02551687,-0.051967144,0.11283723,-0.03197941,-0.014047737,-0.007850624,0.06270673,-0.008154941,0.028134272,0.0017554623,0.08279834,0.02344698,-0.023843652,0.07965335,-0.060998272,0.020698072,-0.08420479,0.031950835,-0.0031816983,0.027619608,-0.033384494,0.037764072,0.011151014,-0.064988375,0.015483353,-0.022696896,-0.026202656,-0.014218595,0.011313089,-0.030825991,0.057365134,-0.08099027,-0.0071316985,-0.031453684,-0.010643385,0.022902705,0.03371865,-0.057520587,-0.025848875,0.07762249,0.04313466,-0.05396897,-0.05074479,0.03781417,0.014949875,-2.0564267e-33,0.070102975,-0.0033878328,0.07657563,-0.028394919,-0.03779569,-0.034895025,-0.05482337,0.008857955,-0.024143597,-0.039546903,0.005321979,-0.023691775,-0.00980877,-0.03746742,-0.008078646,0.04504687,0.09273988,0.03660871,-0.03179993,-0.0944954,-0.007891413,0.049537532,-0.026954968,-0.09761128,0.0046239756,-0.018613787,0.014906919,0.10463714,0.072840996,0.08218914,0.025515752,-0.017362332,-0.021922085,-0.022454537,-0.09242785,0.06920582,-0.008307361,-0.054277815,0.10321342,0.030740447,0.03773732,-0.050813824,0.03626598,0.051478498,-0.017028445,0.062363856,-0.050229363,-0.039487597,0.009417373,-0.06925442,0.106627844,0.013538261,0.022931712,0.02260353,-0.021738272,0.09259268,0.043484565,0.050474975,-0.075084805,-0.082906805,-0.046831366,-0.05409252,0.043116663,0.021072801,0.025234021,0.019236235,-0.05022406,0.15307304,0.04517605,0.026995255,0.075465016,0.027147533,-0.029974027,0.010805065,-0.027055362,0.016371641,-0.029870166,-0.005552524,-0.0065002786,-0.0077943574,0.003550857,-0.033698604,-0.03622037,-0.10689075,0.015228259,-0.00019966126,0.025207955,0.0679535,-0.07523589,0.08994072,-0.066732466,-0.007708927,0.029608965,0.08856149,0.035982214,-2.3195968e-08,-0.026296036,-0.12280007,-0.06068997,0.013108068,0.006212027,0.059036996,-0.017088097,0.09799263,0.074932374,-0.058885694,-0.075324565,0.06126196,0.013757265,0.02615293,0.047929324,-0.021641696,-0.008116256,-0.015747653,-0.0012740019,-0.042772025,-0.06071489,-0.03698017,-0.04276059,-0.013295816,0.047300156,-0.027095469,0.013747015,-0.058968022,-0.013665672,0.01461155,-0.030086398,0.07033256,-0.0023480454,-0.07302815,0.023615016,0.060796417,-0.06488209,-0.0692039,0.011768542,-0.0009982344,0.01699252,0.10957491,-0.12532476,0.040969606,0.009176947,-0.0054237028,0.023092622,0.09333303,-0.06910746,-0.101202466,-0.010771057,0.006499767,-0.024406608,-0.0151781915,-0.0012022103,0.046853684,0.049024686,0.03431988,-0.046052735,0.047795642,0.028868606,0.055188935,0.18000124,-0.072245255 +3.5.99.2,"Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways.",384,1.0,-0.058516357,-0.00972242,-0.076713875,-0.0049033994,0.052055784,0.0047440305,-0.023483796,0.0054953326,-0.06685677,0.013319329,-0.0028808,0.007945857,-0.058646332,0.051429756,0.0007599198,0.06990853,-0.08588851,0.009388337,-0.04620616,-0.0939454,-0.0045703333,0.093394026,-0.033761363,0.0148223955,-0.038075317,0.010954141,0.050335243,-0.009732391,-0.010960321,-0.0668745,-0.10076295,-0.064700216,0.043191094,-0.03985108,-0.006493439,0.10657388,-0.07287965,0.039784074,0.007316311,-0.037142348,0.053748235,-0.017634233,-0.043790795,-0.030737614,-0.053493053,0.0049037905,0.09656347,0.021165254,-0.010983457,0.039861206,-0.07108621,0.021812122,-0.033615623,-0.0053081037,0.06264908,0.054605223,0.020865155,0.013171129,-0.07269132,0.022177275,0.079880826,-0.053690683,0.017150644,-0.026885264,0.084178604,-0.088024154,0.071078144,-0.03865966,0.011191219,-0.10016302,-0.03850395,-0.0301628,0.002192022,0.0307911,0.007512201,0.0050066453,-0.030805621,-0.007096711,0.031296093,0.055672362,0.025113693,-0.05225206,0.030869419,0.032816853,0.008999916,-0.010105072,-0.017125549,-0.024091594,0.05486885,0.034548853,0.0022379914,0.009112971,-0.027358523,-0.0020775532,-0.066130504,0.016471243,0.000856918,-0.031173505,0.02054667,-0.022921765,0.030100074,-0.03108231,-0.0864866,-0.07827465,-0.042548496,-0.019803185,0.0104450155,0.014160893,0.008435775,0.08292817,0.032860454,0.10432937,0.06367404,0.04884367,-0.03527824,0.14170255,0.030486565,0.01558604,-0.023040563,0.018081386,0.015627418,0.049064424,0.08608981,0.032403976,-0.09394045,-0.032249097,-0.097227626,6.458408e-34,0.0027792496,0.053831812,0.0011083018,0.0012926572,0.011894604,-0.0026941074,-0.057239566,-0.0176413,-0.018388458,-0.13471892,-0.02723339,-0.09825709,0.031220805,0.013080549,-0.04080133,-0.10251955,-0.0028925138,0.037914995,0.070212945,-0.052226473,-0.004807592,0.10616232,-0.022052996,0.060357537,0.034295615,0.066770874,0.11767802,0.0850234,0.02189632,-0.0073944316,0.012235938,-0.082746685,-0.0682793,-0.091022655,0.082586624,-0.01792787,-0.034665816,-0.021719346,-0.024813486,0.035236858,-0.002712985,-0.0002445487,-0.0010618377,-0.009648891,-0.052865867,-0.13552943,-0.034154482,0.10648958,-0.005404119,-0.008893657,-0.015967075,-0.068612695,0.07825014,-0.037592035,-0.07025124,-0.023017067,0.019927243,-0.031802725,0.059016753,0.027482916,0.04431021,-0.01156818,-0.048914455,0.068602405,-0.012712575,-0.0021087923,-0.06156545,-0.0137170935,0.035611216,0.06692653,-0.0027968583,-0.026589159,0.08413287,0.014996495,0.058548577,-0.0943574,-0.08285677,0.097470485,0.005629213,-0.04349533,-0.021999845,-0.020602196,0.019381342,-0.014939523,-0.04476328,-0.0731609,0.020160561,-0.045954935,0.0003916103,-0.01147646,0.024771843,-0.014895479,-0.041648418,0.02572054,0.060566343,-2.8744626e-33,0.09091012,-0.08066291,0.09192666,-0.07277205,-0.029978113,-0.012542729,-0.0064376537,0.004544417,-0.061616097,-0.10720434,0.0033276428,-0.0035011766,0.01704786,-0.026587803,-0.0121131595,-0.028449206,0.017170396,0.032134414,0.0028626022,-0.06907275,-0.0031857218,0.011894795,0.024699997,-0.033343736,0.009894906,0.006751442,-0.010668188,0.063714765,-0.013897582,0.08654634,-0.034069985,-0.044715796,-0.08726238,0.010590288,-0.013434253,-0.018127669,0.02320864,-0.07840011,-0.008413189,0.002025356,-0.016570259,0.017052388,0.058577575,0.0971451,-0.013239309,0.057219792,-0.017003883,-0.0048741633,-0.020840177,-0.071239874,0.102609195,0.035588436,-0.033078924,-0.004124928,0.046835303,-0.014618993,-0.0070764534,-0.012751903,-0.011948157,-0.0005667299,-0.051801506,-0.102947876,0.017894933,0.04066767,0.04213946,0.032290924,-0.04000124,0.060843315,0.06423572,0.03304954,0.12242628,0.07748209,-0.005935083,0.02320172,-0.11041859,-0.022437837,-0.035729602,0.074571036,-0.020885294,0.008727518,0.006817997,-0.06715187,0.0065015024,-0.050310493,-0.0021966035,-0.0965054,0.059650224,0.08048857,-0.040406678,-0.006003743,-0.06395113,-0.017574057,-0.091455914,0.06284982,0.058478434,-3.2205133e-08,-0.03860129,-0.114934325,-0.06988654,-0.005836468,-0.0062291883,0.02102484,-0.065496504,0.08353543,0.11362852,-0.06320103,-0.063151635,0.066300705,0.053272877,0.032906577,0.039504476,0.015906412,-0.00464562,0.05615626,0.029688193,0.0056322897,-0.05234853,-0.0050916374,-0.08075626,-0.00071602804,-0.004625549,0.026658064,0.0044157784,-0.008654513,-0.03145009,-0.04840369,0.016596422,-0.018192327,0.056144938,-0.0318358,-0.0111141605,0.059306845,0.03737459,-0.06024548,0.0061744708,-0.011914739,-0.005917922,0.04128941,-0.052727,0.044792447,0.027608624,-0.029892517,0.012441142,0.101391464,-0.048756666,-0.072194174,0.023433952,0.061555326,0.011501678,-0.040956505,-0.07348139,0.040770102,-0.0029051034,-0.00074242987,-0.0078083365,0.019406976,0.11374628,0.060716655,0.18386719,-0.01400094 +3.5.99.3,"Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine.",384,1.0,-0.036802612,-0.024801506,-0.09180924,-0.01840591,0.059161622,0.078065395,0.04675317,0.10669777,0.014033705,-0.0034827802,0.057946514,0.066409916,0.02409325,0.010017152,-0.07455232,0.07320172,-0.026253859,0.038474265,-0.04443969,-0.020403393,-0.0025357264,0.05809297,-0.055832185,0.004900751,-0.0047711665,-0.01651955,-0.0054199416,0.025216153,-0.000314362,-0.073393226,0.07774557,0.05057605,0.022148287,-0.03333382,0.07901368,0.024093205,-0.026149457,-0.051695008,0.12693301,0.05852357,0.02065722,0.04556105,-0.058845032,-0.0038468353,-0.009149907,0.02015989,0.0014547149,0.044038177,0.031625666,-0.04277017,-0.01574191,-0.0056606303,-0.012208387,-0.008773245,-0.051907267,-0.0793083,0.005979147,-0.029295895,-0.096747115,0.061740555,0.049500365,-0.02947055,0.032477427,0.02908938,-0.04060539,-0.018953344,0.055037,-0.024779765,0.09314209,-0.017695839,-0.045233376,-0.058341216,-0.020746134,0.030037943,-0.023278167,-0.08775739,0.031155344,-0.055191208,-0.03475662,-0.11876123,-0.0299769,-0.060404066,0.037801784,0.00020591645,0.037202578,-0.08453748,-0.040072944,0.036543325,0.13143437,0.026211329,0.067007594,0.044861533,0.06056847,-0.051587317,-0.08968779,0.054815605,-0.04596712,-0.09972066,0.011761182,0.023519808,-0.005362552,0.011596222,-0.13138723,-0.04594928,0.036908522,0.028397454,0.05142324,-0.0007211762,-0.015650129,-0.0022352883,-0.035727084,-0.041816004,0.023924233,0.048501402,-0.03478523,-0.025390983,0.09736651,-0.021789985,-0.05446245,-0.049276672,0.0030583933,-0.05155458,-0.010646313,0.024509298,-0.047430452,0.026628371,-0.08395249,3.9111516e-34,-0.0056256633,0.01574155,-0.04654365,0.014431788,-0.005980198,-0.0061837514,-0.010951869,-0.06583465,0.0055855806,-0.093866706,-0.06432638,-0.17622095,-0.0052119787,-0.010606454,-0.043919787,0.02612807,-0.011585772,0.058500156,0.055689767,-0.00012987081,-0.06434086,0.08132383,-0.07547776,-0.04410659,0.051089548,0.09852856,-0.0054824883,-0.0022345695,0.011468202,-0.01594101,0.02194378,0.0058683907,-0.10200186,0.021445246,0.07371206,0.0036097087,-0.0879839,0.09127887,0.034238067,0.087842286,-0.04615897,0.027589066,-0.03580625,-0.00024406689,0.10284996,0.005638517,-0.066008665,0.14325157,0.054218955,-0.0008515111,-0.035261024,-0.04353429,0.06842107,0.00305246,-0.051530022,0.046117496,-0.020829018,0.011908832,0.06083686,-0.001809069,0.03920038,0.027842583,-0.11562247,-0.006023309,0.06691082,-0.031457126,-0.0034101654,-0.0070322263,0.049389552,0.056811515,-0.09435879,-0.0017597568,0.027945193,0.10807611,0.043466594,-0.07041103,-0.08340223,0.019162944,0.03210966,0.026674256,-0.03224839,0.042340122,0.057814464,-0.022791332,-0.06939484,0.03246964,0.013470798,0.018815003,0.02507619,0.002537533,0.16669314,-0.08409307,-0.054957714,0.029640324,0.0223509,-1.715055e-33,0.0112392595,0.029239675,0.017498448,0.013556164,-0.046867527,0.015518815,-0.010493802,0.010147161,-0.032507796,0.052697707,0.09508797,0.035975035,-0.07537138,-0.021436483,0.068494916,0.010739685,0.062178575,0.04490704,-0.063743725,-0.0546738,-0.01853386,-0.02599508,-0.03160634,0.020727543,-0.061764166,0.03923873,0.019755052,-0.0094177695,0.07594188,0.04388263,0.011979609,-0.03443859,-0.03991362,-0.06209291,0.039715532,0.04728031,-0.0550786,0.034422122,-0.11709985,-0.041730076,0.031919446,0.01961671,0.05087502,0.0077351057,-0.019674968,0.00813792,-0.050606318,-0.034878332,-0.068784446,-0.06808642,0.03818962,-0.037225466,0.016819332,-0.003320687,0.04446758,-0.032443352,0.04101056,-0.012345298,-0.02829698,0.033781465,-0.014156981,-0.023864157,-0.017329507,0.0076202094,0.019849034,0.03561703,-0.03213207,0.109181456,-0.0007964322,0.0012768863,0.020775748,0.07743807,0.013510187,-0.059858933,-0.092380434,-0.021959169,-0.08107976,-0.037989855,-0.013302279,-0.0044465573,0.024115043,-0.03221364,-0.06911922,-0.017891077,-0.048390094,-0.043269664,0.0009286003,0.09012723,0.07270059,-0.009815367,-0.023579046,-0.0131949335,-0.020641122,0.002167037,0.00085220084,-4.157533e-08,-0.0008865982,-0.054443575,0.04745003,-0.023294214,0.02569515,-0.0059975963,-0.04690676,0.087584496,0.029096123,-0.013025548,-0.017639674,0.093785964,0.04399489,0.0008953536,0.0127004385,0.038459167,-0.061528586,0.018683925,0.013897884,0.0053956476,-0.083447374,0.013511368,-0.15073586,-0.042903125,0.050072227,0.01213421,0.02902154,0.028713973,0.08953314,-0.056892406,0.07373115,-0.03423515,-0.009185525,0.023543544,-0.07002421,-0.02431448,0.00039553878,-0.08083765,0.029801736,0.03513385,-0.015955383,0.047387432,-0.086110264,0.027015451,0.10469133,0.0043653706,0.0405329,-0.01903841,-0.09703263,-0.046198327,-0.0009992562,0.0032405858,0.010135425,-0.0019687335,-0.049220692,-0.059989836,0.02008147,-0.03744039,-0.017474357,0.0014198676,-0.036179602,-0.0044260332,0.13686855,0.073633105 +3.5.99.4,"Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopopylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine.",384,1.0,-0.04013716,-0.029025666,-0.09568136,-0.01986504,0.06401079,0.07864238,0.043482676,0.10323397,0.027914304,-0.0019114861,0.064161085,0.06347275,0.020963747,0.020437084,-0.067797765,0.066910155,-0.020779382,0.04124031,-0.03880335,-0.03581709,-0.010963146,0.048310943,-0.053884193,-0.005093705,-0.0074845715,-0.0184561,-0.006922581,0.02529255,0.0027301596,-0.057774875,0.07967289,0.054627944,0.028081475,-0.04612129,0.07301292,0.033242352,-0.015197217,-0.05785247,0.1249075,0.054754183,0.013077313,0.04742177,-0.044329986,-0.017771436,-0.009482337,0.021509087,0.0028365275,0.054015927,0.036175985,-0.043367095,-0.0013593613,-0.011721243,-0.019328235,-0.00591426,-0.044199772,-0.07616385,0.0043877224,-0.032870013,-0.10524935,0.05861805,0.047437552,-0.028410275,0.03242586,0.028777635,-0.045669604,-0.011773797,0.056076556,-0.03459576,0.08847756,-0.019893052,-0.0464172,-0.05932036,-0.016082091,0.024961954,-0.028823623,-0.08430218,0.020875927,-0.058189526,-0.028212855,-0.11594436,-0.028890558,-0.06334017,0.02793278,-0.0022820486,0.024017416,-0.086369954,-0.043281354,0.03838642,0.13148645,0.030087683,0.06858994,0.04021945,0.06356895,-0.04909071,-0.099148184,0.06206164,-0.046180747,-0.110420704,0.011890671,0.0147582,-0.015581161,0.013833843,-0.12732881,-0.044536084,0.032379437,0.020327494,0.044774286,0.02036594,-0.014714455,0.0029688217,-0.028621128,-0.030057456,0.04427558,0.045148954,-0.032703657,-0.032751206,0.09621303,-0.026582705,-0.06561167,-0.04458613,-0.0027417066,-0.04653876,-0.008371577,0.030858504,-0.034106605,0.031557035,-0.06881327,1.2328746e-35,-0.0028692419,0.009513263,-0.03234138,0.018123422,-0.00788075,-0.007295736,-0.013030689,-0.063192084,0.01722839,-0.08130648,-0.075456515,-0.17162819,-0.0029873755,-0.02106403,-0.04289661,0.024195125,-0.016938819,0.06306989,0.053579926,0.008782103,-0.060432065,0.08261362,-0.06228541,-0.03697599,0.061874144,0.11757518,-0.00051056436,-0.005147307,0.016324291,-0.016693035,0.009837886,-0.00313117,-0.10327593,0.004949543,0.07331015,0.0072979033,-0.0884793,0.094197065,0.025549399,0.08205892,-0.03634501,0.02548146,-0.04438679,0.00515595,0.09072966,0.008818659,-0.06024202,0.14272203,0.058893222,-0.014429677,-0.03076343,-0.051680233,0.060878042,0.019853517,-0.061532248,0.0438882,-0.015021893,0.0036932917,0.05918378,-0.0050281803,0.045437466,0.03425942,-0.11294359,-0.0138126835,0.07870542,-0.036684465,-0.0058929026,-0.011085991,0.04753246,0.06439566,-0.085130654,-0.0032804003,0.0041529317,0.11791222,0.046410132,-0.07719766,-0.06809555,0.011478153,0.043917418,0.026484251,-0.026184045,0.031019347,0.06484889,-0.024163065,-0.06752893,0.039640475,0.013141732,0.029389696,0.02468775,-0.0045262487,0.15742174,-0.07796941,-0.051414873,0.03446813,0.011175056,-1.38329145e-33,0.001565415,0.011103865,0.005638457,0.004316272,-0.040239748,0.024386603,-0.021971079,0.018520907,-0.023535429,0.047245406,0.07449987,0.049056344,-0.063375145,-0.0065880297,0.059909903,0.015843047,0.061907146,0.04324586,-0.06104587,-0.056393124,-0.03312411,-0.02997473,-0.031974144,0.030399978,-0.0665125,0.050716877,0.0220285,-0.012943907,0.07090977,0.055866685,0.015819194,-0.034792855,-0.033795167,-0.06064887,0.039373126,0.04919425,-0.049994487,0.039828435,-0.1155057,-0.040570725,0.02947866,0.015987072,0.050398123,0.018340029,-0.022980541,0.011356221,-0.06905714,-0.022202611,-0.089086965,-0.062234078,0.020123374,-0.035531085,0.023585942,-0.00040655633,0.046200853,-0.034970913,0.04093547,-0.023333004,-0.012128963,0.026049498,-0.019873358,-0.024385227,-0.026501108,0.014168806,0.026196206,0.044067107,-0.021454526,0.10952996,-0.0087142205,-0.0011785947,0.01457216,0.07869259,0.014200898,-0.06478388,-0.09180246,-0.014720883,-0.083834745,-0.028810477,-0.002860875,-0.014547808,0.02826053,-0.027679618,-0.06572225,-0.021466943,-0.065278225,-0.04021374,0.0076005375,0.11187167,0.07461382,-0.0047782646,-0.0318304,-0.010180221,-0.028156262,-0.010349836,0.009251155,-4.2096534e-08,-0.013421256,-0.04707693,0.058400113,-0.028302748,0.015039891,0.004116902,-0.03852869,0.09438081,0.04112823,-0.022810884,-0.011436117,0.086707726,0.037531577,0.010153227,0.0049855346,0.043305203,-0.06591138,0.018975822,0.0052422807,0.017681098,-0.08656999,0.017287696,-0.14729877,-0.055431318,0.05119468,0.004939281,0.022388257,0.024999166,0.07567435,-0.05679357,0.073510624,-0.032428395,-0.0224022,0.028993769,-0.081517406,-0.012151366,0.009922942,-0.08217022,0.02673154,0.034170963,-0.01980245,0.04214682,-0.08656126,0.020902105,0.08833622,0.012992606,0.050983734,-0.022419268,-0.089891836,-0.03658043,-0.0036908395,-0.002326207,0.00036069754,-0.003964088,-0.061478194,-0.07031897,0.01818418,-0.051068474,-0.0003854194,-0.004861339,-0.033422384,-0.0026685207,0.13731779,0.08418028 +3.5.99.5,"2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.",384,1.0,-0.036122102,-0.047974527,-0.038100645,-0.060064152,0.04688492,0.067980394,-0.021528153,0.10151058,0.005241352,-0.008179288,-0.007893323,-0.046825506,-0.04164197,0.07761956,-0.11350898,0.03836796,0.0026750288,-0.0026859173,0.018670565,0.05154686,0.040078823,0.036482237,-0.0029221256,-0.049195115,0.014967737,0.027679149,0.06417286,-0.027478471,0.03265649,-0.03368206,0.025637334,-0.008621889,0.045874216,-0.0676221,0.10529908,0.027774084,0.012359445,-0.03478142,0.047902014,-0.017331744,0.027997443,0.024929535,-0.04403842,-0.05827654,0.06835801,0.010648342,0.034849387,0.008267059,0.06468215,-0.11958731,-0.07990632,-0.074247904,0.03352715,0.04421994,0.032239348,0.04200467,0.013418928,-0.069251254,-0.04263068,0.0455187,0.10056504,0.0053457106,0.0039186627,-0.025018018,0.03256711,0.0043977485,0.030502534,-0.011617521,0.021701323,0.019436987,-0.044162482,-0.07959402,0.05771392,-0.004572088,0.02398393,-0.058121044,0.03977654,-0.040191274,-0.014900683,-0.12440215,-7.3496276e-06,-0.0414981,0.07922124,0.006758089,0.003992105,-0.005493769,-0.016743599,0.05493363,0.090838484,0.0008372337,-0.047133576,0.056835994,0.058144163,-0.022108193,-0.059996713,0.029935654,-0.045671433,0.094188675,0.10033801,0.008542282,0.032714985,0.062257487,-0.018439645,-0.09622841,-0.009720108,0.06244519,0.029781692,0.09075368,0.07611471,0.010221248,-0.02018345,0.00077376986,-0.045699164,-0.043288115,-0.01743643,0.037468597,0.15343669,-0.030927032,-0.07283981,0.01431557,0.032758158,-0.040936697,0.008035534,-0.015326773,-0.08018394,0.063773684,-0.008762138,5.021743e-33,0.031305946,-0.04794066,-0.036442347,-0.019744594,0.034948397,0.0048694503,-0.08892546,-0.08741698,-0.0029668002,-0.078591704,-0.006262192,-0.09883143,-0.07215072,-0.017129026,0.01710704,0.051615953,-0.061329532,0.039419867,0.051808592,0.013594134,0.008523306,0.09899876,-0.08377197,0.0003986644,0.07513652,0.0037751417,0.05117045,-0.029410698,0.008342589,-0.048899252,0.012684736,-0.03501827,-0.14794561,-0.058812734,0.048171937,0.010323447,0.008908833,0.04756873,0.014324032,0.040824838,0.02370095,0.008123833,-0.04330287,0.015489991,0.09845342,-0.0017693344,-0.0636612,0.07958282,0.08129593,-0.052823685,-0.012045348,-0.04030658,0.0022205168,0.045101948,-0.028474066,0.036242858,0.02457528,0.014240463,0.10598287,-0.009599247,-0.013870039,-0.002939754,-0.041927386,0.036985278,0.021338446,-0.07518212,-0.05143803,0.08845204,0.06075286,0.043163743,-0.1202786,0.0021974489,0.039122343,0.07525696,-0.0039488464,-0.16478871,-0.08517288,-0.043282546,0.00042659082,-0.01294533,0.075773016,-0.020458022,-0.01284653,-0.0029386084,-0.06319633,0.07705341,-0.026410721,-0.034952924,-0.030438237,0.009984124,0.06831582,-0.06679908,-0.08065656,0.04007985,-0.05127322,-4.8338557e-33,0.06577097,0.014292136,-0.03342596,0.03593954,-0.068248205,-0.022184195,-0.05175343,0.095871255,-0.029904302,-0.01693776,0.033917397,-0.026267853,0.09795969,0.009056609,-0.033079617,0.038604155,0.004806413,0.01211842,-0.05836404,-0.09200844,-0.0149086695,0.019713255,-0.010553974,-0.00062948174,-0.00027364443,0.08396098,-0.022300707,0.12277765,0.054796513,0.0663201,-0.022360789,0.042129647,-0.07337299,-0.070883155,0.012080296,0.033467676,-0.039531585,-0.03988848,0.00013626718,0.00029536706,0.015939351,0.045589577,-0.0026414136,0.02188917,-0.019444184,0.09522373,-0.058317777,-0.03565529,-0.0076376963,-0.090538315,0.01041514,0.021253195,-0.05814935,0.047340985,-0.028091524,-0.022151403,-0.0007592325,0.04858886,0.009047444,0.04308701,0.016173605,-0.021229418,0.021373741,-0.017852582,0.07166176,0.011534768,-0.055346753,0.13646743,0.004797016,0.0140969055,0.003593896,0.0585519,0.063238114,0.06762793,-0.06700612,0.001518335,-0.0054603796,-0.033937592,0.014808189,-0.06560172,0.05514928,-0.038454104,0.0317175,-0.046098,-0.025827434,-0.07200343,0.039744012,0.08864476,-0.007688008,-0.03339924,0.029365333,-0.032809064,-0.0637776,-0.011910537,-0.056005616,-4.0749434e-08,0.06265005,-0.034870666,0.050674267,0.012973417,-0.014350143,-0.025981588,-0.027861625,0.013486324,0.07755032,-0.03141107,-0.03748012,0.044889215,-0.034696,0.059154242,-0.046412937,0.072225526,-0.06657579,-0.03515468,-0.00539179,-0.014126532,-0.09106343,0.015577512,-0.069042526,0.0124360025,-0.040169314,0.0006380158,0.044631753,0.06723757,0.061613042,-0.07318567,-0.092626266,0.050888136,0.054031547,0.017884824,-0.008135396,0.03614607,-0.05270071,-0.040434852,-0.010778125,-0.050472707,0.00018613246,-0.06576352,-0.03345104,-0.004867509,-0.006325091,-0.029193075,0.010659012,0.0169772,0.005445384,-0.06823832,0.061246604,-0.073577024,0.01603766,-0.026901098,-0.14399606,0.019061537,-0.025815679,0.019960966,-0.018948264,-0.08722365,-0.05990226,-0.041695096,0.083594665,0.014905555 +3.5.99.6,"The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.",384,1.0,-0.009542157,-0.031350587,-0.07936671,-0.028668994,-0.008007391,-0.00874336,-0.04402171,-0.0064981366,0.049896404,0.05470348,-0.011230443,-0.0003075561,-0.045142867,-0.045161687,-0.083914086,0.0603537,-0.022836737,-0.006141261,-0.05740349,-0.053326707,0.1341987,0.012746576,-0.041510083,-0.05022976,0.049078062,0.017350834,0.07108858,0.042976867,0.02461802,-0.08903029,-0.0372778,0.0032892118,0.03906252,-0.033166178,0.013623698,0.13967174,0.02886318,0.007397947,0.002619983,-0.0017255258,-0.0055561177,-0.018538052,0.028750366,-0.05402295,-0.04989622,-0.050801273,-0.01711839,0.068557285,0.088100255,0.040313385,0.0079891775,-0.058369488,0.010013976,0.040938266,0.03740609,0.04174424,-0.10194594,0.0015368552,-0.070333615,0.066239186,0.020470893,0.038883265,-0.03004096,0.024764346,0.036023762,-0.053726744,0.022970527,-0.06272927,-0.038408365,-0.07597271,-0.024642015,-0.07132338,-0.005947575,-0.040656786,0.031175599,-0.033549633,-0.12075146,-0.056029577,0.05440227,0.026890906,0.05593249,0.034973115,0.088938326,0.0719178,0.06692677,0.026839333,0.02081931,0.009846085,0.053057615,-0.006939448,-0.023892622,-0.06693151,-0.06559558,-0.050149757,0.0034625544,-0.033030372,-0.007525663,0.05230853,-0.0023336485,0.0040584765,0.028297896,0.04124035,-0.026408302,-0.09940946,-0.025692124,0.038336325,-0.03976068,0.14317068,0.02078605,-0.006041644,-0.07427566,0.04255097,-0.006808515,0.010870863,-0.060018804,0.12042717,-0.017481256,-0.059409928,-0.027668724,-0.017300826,0.040676836,0.03966809,0.023548646,0.08438664,-0.0483698,0.04516246,-0.050284207,3.0786812e-34,0.035252053,0.028629826,0.028311161,-0.043041766,-0.02923968,-0.020556996,-0.051066283,-0.00087222614,-0.033735316,-0.014810035,-0.058438208,-0.028449602,0.08353733,0.03439894,0.039309837,-0.005608554,-0.014568581,-0.029220765,0.05637197,0.0034321682,0.074685514,0.09971865,-0.06616059,0.045988295,-0.046924785,0.07661703,0.026571436,0.0707108,0.017880037,0.0058855773,0.0031015053,-0.050739866,-0.08756186,-0.016870208,-0.02885805,0.036931667,-0.10510543,0.03825642,-0.040561408,0.05814477,0.0568068,0.0033937946,-0.015850622,-0.017533245,0.009634528,-0.016791973,0.004655331,0.058419034,0.049129885,0.11597515,0.04283991,-0.02450454,0.054548886,0.05062648,-0.09732031,0.03368309,-0.010493544,-0.06456114,0.0075569483,0.06536684,-0.010907439,-0.035859924,-0.018893816,0.07702403,-0.028508734,-0.026884116,-0.066092715,-0.054287706,-0.018365227,0.10875496,-0.07559704,-0.010373353,0.0021407953,0.0631317,-0.0049399566,-0.05322223,-0.031975657,-0.010087284,0.00069133675,-0.008616317,0.09492447,-0.0053595775,-0.004456176,-0.040978577,-0.10601735,0.03499005,-0.02949876,-0.10155466,-0.027427414,0.009377354,0.022902511,-0.09107216,-0.077640265,0.059955217,0.04606573,-3.1171972e-33,0.14458394,-0.07828931,0.085916825,-0.044249915,-0.027302582,0.03151004,0.08784718,-0.022765059,0.016481047,-0.031334583,0.07135277,0.001955998,0.0069139395,0.03448119,0.012561295,-0.044669174,-0.011149586,0.060316537,0.03928175,0.041618768,-0.00451217,0.053407606,-0.043298118,-0.032678105,0.059038773,-0.031013785,0.041065834,0.012003537,0.07041698,0.04798153,-0.04806732,-0.045086797,-0.022994207,0.034599494,-0.04138552,0.08510954,-0.07994198,-0.013969119,-0.032604776,0.010300438,-0.022519343,0.0810988,0.0023602946,0.021374835,0.03429644,0.048925348,-0.07166686,-0.014430149,-0.04689457,-0.09319054,0.056433186,0.029804226,-0.010214472,0.024282617,0.022938987,0.022022035,0.027230991,-0.029726787,-0.04879244,-0.015771229,-0.07210047,-0.039811112,0.04093279,-0.051749077,0.026966842,-0.028440598,0.0026580605,0.03717328,-0.022422936,0.07797529,0.0014080208,-0.011824888,0.05606021,0.041166738,0.0057930653,-0.074687876,-0.106922835,-0.007999,-0.036012575,-0.058153138,0.018809248,-0.063893475,-0.015376021,-0.012049477,0.018913774,-0.04900302,0.09032563,0.054247133,-0.004509782,0.07753129,-0.025913918,0.003241344,-0.050398026,0.020542966,0.06434337,-4.392853e-08,0.042308003,-0.13333087,0.019186487,-0.050091725,-0.0015389397,0.07058308,0.030960906,0.004458828,0.01175861,-0.05495366,-0.062151853,0.15256588,-0.022918014,-0.0053617153,-0.06468954,0.029865079,-0.028101632,0.07399086,0.024002185,-0.04953566,-0.12669262,-0.037230488,-0.060198445,0.008694822,0.0303032,-0.014416965,0.02393265,0.061170172,0.016367482,0.018732123,-0.029012073,0.040450104,0.0009236104,-0.09530546,-0.10236944,0.04688386,-0.06970981,0.037332382,-0.036654,-0.025141966,0.055384316,-0.0018323495,-0.045346815,0.0011186461,0.032332342,-0.010721902,0.007894918,0.016797666,-0.035658885,0.061667014,0.05558728,-0.026125139,-0.033305496,-0.07137984,-0.05486299,0.0020414842,-0.029289003,-0.105136,-0.0042491686,-0.010929853,-0.03412559,0.041287705,0.1668869,-0.026881682 +3.5.99.7,"A pyridoxal 5'-phosphate enzyme. The enzyme, found in certain soil bacteria and fungi, catalyses the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation.",384,0.99999994,-0.03572982,-0.046427656,-0.04330806,-0.027557127,0.14109808,0.008451971,0.044572175,0.033053294,0.03983216,0.061163843,0.07419976,-0.0503087,-0.0570958,-0.004416053,-0.04654029,0.061590753,-0.07915786,-0.006832626,-0.013134802,-0.096576855,0.099707186,0.02212518,-0.041167617,0.0071565076,-0.031802952,-0.0012546206,0.014670455,0.03443799,-0.050050117,-0.12460512,-0.020535015,-0.005270704,0.045517776,-0.033639688,-0.0098672435,0.054267712,-0.041579038,-0.06057397,0.02350503,-0.04755273,0.04664237,-0.027913129,-0.018061582,-0.033157527,-0.05987866,-0.027508827,0.03185019,0.034105085,0.014131765,-0.07916877,0.013224899,0.010345546,0.013321019,-0.03939123,-0.015466168,-0.0039427667,0.07077917,0.026697224,-0.031108962,0.01740219,0.068404645,-0.014730139,-0.035926763,-0.034747444,-0.009510148,-0.010777723,0.038611505,-0.06295899,-0.014648578,0.012367812,-0.05736434,-0.058412794,-0.008869523,0.02324089,0.044459436,0.025313381,-0.05029424,-0.039108466,-0.034705635,0.049114276,0.0034403726,0.022281427,0.02766172,-0.041470807,0.023097139,0.021438606,0.023259595,0.036186256,0.06250883,0.01724271,0.031271685,0.012152269,0.0068226047,0.05617736,-0.04165053,0.06140736,-0.028245438,-0.05156209,-0.02612189,-0.013870149,-0.0122083705,0.074694686,-0.090361215,-0.07005149,-0.08817584,0.016275994,0.0124089,0.005934296,0.0034038848,0.024837472,-0.09864642,-0.057711888,-0.019100552,0.049581196,-0.039040048,0.112495095,0.05438807,0.029281337,-0.028210972,-0.05302113,0.058742195,0.0069011594,-0.005622372,0.10371693,-0.08009891,0.023258377,-0.092801586,2.4000489e-33,-0.034706157,0.033576198,0.0074591795,0.017704722,0.027733738,-0.03722437,-0.08502205,0.047571894,0.014408443,-0.07434477,-0.068387195,-0.034718286,0.025759315,-0.008260326,-0.012304299,-0.10184345,-0.03182628,0.0791883,0.061709095,0.0477028,0.008419186,0.011599238,-0.100472905,0.03549532,-0.0014537277,0.07383957,0.033135388,-0.015469714,0.10282744,-0.04234887,0.049237967,-0.053872265,-0.09937416,0.004992708,0.027038515,-0.060784686,0.0029999188,0.025616214,0.06304663,0.10500938,0.0018313554,-0.00020434755,0.082909435,0.015768625,-0.0065509058,-0.07591235,-0.05460286,0.09437671,0.024135517,0.06195936,0.021550747,-0.014016019,0.120038986,-0.023789125,-0.06486607,0.015475235,-0.045340013,-0.04565236,-0.0044244584,0.0015760002,0.043964595,0.0038349205,-0.021123854,-0.02814315,-0.07731452,0.016206263,-0.0361926,-0.039548807,0.026042568,0.11558311,-0.0682046,0.010414919,0.05591285,0.050703924,0.020762293,-0.036344714,-0.08955335,0.027411213,0.0053797257,0.016092073,-0.06624342,-0.02420475,-0.03826308,-0.0073410254,-0.054389983,-0.0058919517,-0.075514816,3.2673557e-05,0.05234404,0.074964896,0.05652298,-0.053541087,-0.024002913,0.028552776,-0.011166493,-2.5623846e-33,0.10518037,-0.060417455,-0.012737939,0.0034070483,-0.007868446,0.03348081,0.038086176,-0.006415803,-0.028974524,-0.08686593,0.0044102427,0.048417147,0.04155075,-0.0103807915,0.032105725,-0.0026209122,0.026977446,0.0775026,-0.025837945,-0.020994812,-0.010148801,0.028675653,-0.029055523,0.0034697761,0.04113491,0.06009741,0.017603453,0.027264522,0.014908308,0.03097178,-0.02267242,-0.024907613,-0.013634106,-0.022097506,-0.053113732,0.0949866,-0.05099979,-0.087966226,-0.045435473,0.09653585,-0.05956941,0.102995194,-0.029135225,0.011487387,-0.020057604,0.047303524,-0.028970927,0.10227187,0.06622583,-0.012636519,0.040811367,0.08408931,-0.01987837,-0.038685426,0.020907603,0.033698402,0.016985413,-0.0015528287,-0.017746607,0.037090644,-0.007120655,-0.02051363,0.01273456,-0.03819299,-0.011871634,-0.0009206612,0.026444629,0.06514047,0.011512608,0.021814417,0.11128983,0.017669247,0.039039265,0.02712169,-0.07031107,-0.009002854,0.018881103,-0.065211035,-0.041392267,-0.09386607,-0.016443603,-0.031500015,-0.012644672,-0.07253543,-0.031262465,-0.09281603,0.031783693,0.05377185,0.01812906,0.040962983,-0.010920503,-0.0316843,-0.0030281418,0.14363652,0.06580768,-4.430616e-08,0.05623057,-0.102637656,0.03030336,-0.031802773,-0.00016028807,0.012023948,0.08542631,-0.007496302,0.07055695,-0.11820544,-0.056783676,0.044449005,-0.0039309184,0.07398875,0.06581898,0.042533435,0.040184703,0.09872907,-0.014017062,0.0048692725,-0.10196839,0.0073831277,-0.22126354,-0.022676993,0.02675959,-0.008321695,0.02199367,0.081080355,0.031671584,0.022762103,0.043286882,0.05195702,0.026334519,0.011683389,-0.024597185,0.083926655,-0.09040372,-0.0070288423,-0.07253793,-0.052566815,-0.0108876685,-0.0036640305,-0.09499824,-0.02561264,0.0002663797,0.0017472733,-0.030929264,0.01392205,-0.010477375,0.04225607,0.014145952,0.024556542,0.03621898,-0.027552027,-0.068707295,0.04186199,0.003560148,-0.08508387,0.030136257,0.0074999505,-0.020769417,0.018810892,0.18878406,-0.024178758 +3.6.1.1,"Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC 3.1.3.1 (alkaline phosphatase) or EC 3.1.3.9 (glucose-6-phosphatase). cf. EC 7.1.3.1, H+-exporting diphosphatase.",384,0.99999994,-0.06586066,-0.054204244,-0.07072755,-0.03048847,0.08604028,0.0022116576,0.023254545,0.01601889,0.0022049223,-0.026929433,0.022926074,-0.06745973,-0.06488331,-0.023364974,-0.011582023,-0.048598435,-0.045965895,-0.04845542,-0.017705377,-0.011468381,0.11062624,-0.012557759,0.0060649347,0.0049731727,0.04643955,-0.0011002352,0.055713296,0.015374503,-0.0058877217,-0.094085656,-0.08476337,-0.013724421,0.0766833,-0.06600734,0.03689325,0.079043895,-0.08971145,-0.036372885,-0.05770238,0.03770993,0.09554169,0.021428742,0.021844685,-0.03790249,-0.04400644,-0.037405416,0.016635347,0.024864202,0.029407958,0.045101427,-0.05636318,-0.08041982,-0.012834754,0.024244135,0.010839162,-0.019457476,-0.10041816,0.052107967,-0.013515121,0.00022096212,-0.071902044,-0.000206596,0.047580887,0.0019410604,0.10216795,-0.024063844,-0.007805273,-0.12993698,-0.026518177,-0.035941377,-0.087039076,-0.08333731,-0.01950439,-0.026476,0.025579562,0.055804,0.0771077,-0.045836564,0.016533645,-0.054312963,-0.005564461,-0.017179625,-0.034601938,0.013352672,-0.0011629589,0.019170865,0.028062204,0.023237657,-0.0016256648,0.032402962,0.024296286,-0.045022193,-0.017472649,-0.034976188,-0.07032665,0.11503168,-0.0034990367,0.09990688,0.09022364,-0.025930598,-0.0059571057,0.11341731,-0.036489643,-0.02033706,-0.02632355,0.009324792,-0.0018697812,0.071069136,-0.01927018,0.0337859,0.014633239,-0.021953424,0.039395675,-0.022661401,-0.025128214,0.08178951,-0.007809068,-0.11821507,-0.052924532,0.017438035,0.04036232,-0.0514106,0.087690346,0.054645225,-0.010168352,0.09389942,-0.10675334,-4.7396887e-34,0.04093022,-0.037644148,0.020950858,-0.07018723,-0.02893728,0.008385045,-0.05606483,0.042935688,-0.015898082,-0.029578192,-0.056745917,0.0039632,0.09261503,0.008514326,-0.055958077,-0.038584303,0.009937706,0.017889183,0.03984431,0.029284088,0.026980938,0.017874338,-0.09518735,0.054758176,0.034008622,0.048553463,-0.029197926,0.024867455,-0.00054685003,-0.014933159,0.056039758,-0.0660258,-0.040747028,-0.03366295,0.035888873,0.026116068,-0.0040879594,-0.021718664,-0.013368991,0.023493284,0.037195362,0.037589718,0.02686968,-0.014551441,0.06922465,-0.06393569,-0.0860489,0.05983772,0.101607084,0.039010152,-0.00037152666,-0.016901068,0.17189,-0.052796897,0.014370855,0.056197975,-0.08218908,0.039525565,0.06991877,0.069063075,-0.013835987,0.09447191,-0.052842334,0.09133498,0.03389245,0.112200506,-0.047977667,-0.039881706,-0.042738345,0.08408332,-0.053122386,-0.018892325,-0.024174273,0.014957786,-0.014401982,-0.026088633,-0.0780279,-0.020567177,-0.00016498078,0.010653776,-0.025919288,0.0018563601,-0.0035568534,-0.0018536,-0.112197496,0.0011736803,-0.036200147,-0.027464746,0.015623566,0.018980185,0.050602816,-0.009165695,-0.056539312,-0.018491603,-0.022665465,-9.284758e-34,0.05601063,-0.06525382,0.018627983,-0.09470842,-0.017521525,0.087255456,0.071749456,-0.034735773,0.04366909,0.03447645,0.06901589,-0.028853996,0.0011555372,-0.11998623,-0.035141367,0.030994356,-0.09557601,0.08801456,0.052105714,0.028111927,-0.022686742,0.06975295,-0.007913259,0.04204107,0.054672748,-0.0088693965,-0.04419815,0.11428681,0.041598443,-0.009750392,-0.09135632,0.02300001,-0.020563608,0.0011577276,-0.06848132,0.02660341,-0.053556304,-0.005010439,0.07978687,0.064417936,-0.010154133,0.002827105,0.06334858,0.054492973,0.07100911,0.09883188,-0.056222793,0.07025984,0.018303875,-0.048086774,-0.023937281,0.0070950156,-0.013863468,0.025425455,0.010823836,0.055072814,0.02621076,0.017016768,-0.026832907,-0.014017831,0.020880176,-0.05581509,0.041056685,-0.0033404499,-0.0041316296,0.05565082,0.0104848305,-0.033738527,-0.010356894,0.010328756,0.049793676,-0.045334484,0.033425715,-0.014869154,-0.044044983,-0.07161622,-0.020382771,0.031011958,0.0016685808,-0.05852404,0.053979266,0.0932064,0.017530177,-0.011652972,0.053598866,0.014910664,-0.009115601,0.044010337,0.0003595513,0.023817504,-0.089914456,-0.06421955,-0.0976263,0.0004669424,0.0062332996,-4.0512482e-08,0.07704004,-0.0431064,0.07880839,-0.035488237,0.042656705,0.0583807,-0.002715782,-0.0428493,0.039964437,0.015513827,-0.012641091,0.05694588,0.022656797,-0.043973457,0.07942865,-0.035963565,4.63276e-06,0.049712192,-0.035251208,0.0042864312,-0.017337719,-0.017987058,-0.06758272,0.025507329,0.034975402,-0.009026119,0.017621506,0.02619728,-0.08170302,-0.04921545,-0.017408356,0.03741164,0.05806618,-0.026486963,-0.048383027,-0.00097330305,-0.06317486,-0.015212848,-0.09118866,0.03586238,-0.048754383,-0.087169535,-0.061119094,-0.03425714,-0.018775085,0.03663749,-0.013530553,-0.013442977,0.04231574,-0.023007909,0.0065999757,-0.07484491,0.01678012,-0.07281681,-0.033328693,-0.020056581,-0.048235994,-0.10999374,0.03493089,-0.03632709,0.13980643,0.069282286,0.15705626,-0.015153542 +3.6.1.3,Many enzymes previously listed under this number are now listed separately under EC 3.6.3 and EC 3.6.4.,384,1.0,-0.033950467,-0.11687034,-0.050771266,-0.023316992,0.061656654,0.029227149,-0.099058546,0.023414625,0.009429805,-0.058493637,0.046645004,-0.02143179,-0.11111167,0.013100207,0.007484803,-0.014818635,-0.07656251,-0.03125481,-0.035220835,-0.069543734,0.0628456,0.07057004,0.01935348,0.0029214863,0.082065105,-0.038201194,0.026104016,-0.033925127,0.0020339016,-0.049718466,-0.03170113,-0.003704803,0.11055429,-0.029269872,0.041972104,0.028641209,-0.058349166,-0.11413796,-0.0237709,0.068965316,0.047118604,-0.008945682,-0.000288214,-0.06802922,-0.013839557,-0.052441098,-0.022527125,-0.033291966,0.017829968,0.015817804,-0.021924559,-0.11197719,-0.05151374,0.045066744,0.010658434,-0.04710894,-0.081845045,-0.01720518,-0.06405177,0.08122086,0.015464561,0.036390807,0.07169152,-0.004254326,0.037305962,0.025297433,0.066003814,-0.09069992,-0.0061143492,0.008793457,-0.12069545,-0.0895766,0.002471731,0.019547414,0.004381315,0.03971626,0.015369703,-0.033051882,-0.005991846,-0.095942914,-0.038199533,-0.026875459,-0.039080463,0.04782127,-0.00139843,-0.016391855,0.017663078,0.028111335,0.0038681421,0.047669332,0.056264963,-0.048542254,0.02551192,-0.0069352025,-0.012802676,0.038358077,-0.033834975,0.10149462,0.03494445,-0.091064334,-0.035298802,0.055513322,-0.020162873,-0.0077765603,-0.013557196,0.02439206,0.028665505,0.0680946,0.03861325,-0.017865526,-0.00050119206,-0.0049570813,0.02622463,-0.0577651,-0.027400834,0.05876497,0.012042584,-0.05489276,0.08410925,0.08202316,0.03485756,-0.025213653,0.15225492,0.010531655,-0.029061228,0.0888425,-0.13276242,-9.486487e-34,0.021712102,-0.008142166,0.05645692,-0.048118427,-0.026491001,0.018458176,-0.05863223,0.045888275,-0.0442374,-0.01877527,-0.046084102,0.018064423,0.06328465,0.019573456,-0.04211171,-0.04331138,0.04528568,0.042379662,0.008969288,0.006447645,0.028425587,-0.015511582,-0.06178243,0.051064447,0.02854718,0.10990111,-0.0058871238,0.02945337,0.019296467,-0.012472793,0.017615478,-0.073041506,-0.02327011,0.023028327,-0.0070044203,0.075239554,-0.012867933,-0.019731088,0.009032673,0.013072725,0.055400454,0.043609735,0.0150859915,-0.045288034,0.05624944,-0.0229321,-0.08510569,0.095989026,0.09688671,-0.00026344438,-0.011678746,-0.026181016,0.09187618,-0.041733846,0.03902407,-0.005276697,-0.05247203,0.081266716,0.03773438,0.059880998,-0.027380913,0.11592756,-0.04323066,0.015578911,-0.03044934,0.078008905,-0.062419668,-0.018626463,-0.03245593,0.107869074,-0.1046193,0.03504492,0.01702703,0.04170167,0.06504905,-0.049070127,-0.07413272,-0.07156291,-0.020579964,0.025421543,-0.06535306,-0.004223072,-0.0015504258,0.048333462,-0.046944447,-0.02018772,-0.041913424,0.0038081661,0.03222521,0.020248042,0.054154877,-0.030600922,-0.04957326,0.042126738,-0.065518215,-1.12027615e-33,0.05372997,-0.021766892,0.0068918006,-0.053739417,-0.00919758,0.0682348,0.07217611,0.0023301248,0.051028416,-0.014064263,0.10665031,0.0012707873,0.0013637107,-0.110227734,0.05154245,0.019349597,-0.13338242,0.022439903,0.037721265,0.04471748,-0.03527308,0.044055413,-0.018742224,0.052777153,0.051545814,0.016387701,0.040865686,0.013418896,0.051939454,-0.08295296,-0.07041644,0.0016201597,-0.04241273,0.038145483,-0.04774726,-0.018644035,0.010443862,-0.040004756,0.01769265,0.021323457,0.0125281,0.06951799,0.007050128,0.069450036,0.01121563,0.08291763,0.0066381805,0.047169197,-0.025003415,-0.019468015,-0.032465845,-0.047683865,-0.02246845,0.030888278,-0.0019454096,0.07550031,0.00704761,0.038838323,-0.028059153,-0.0123133585,-0.027171452,-0.0076233475,0.060621735,0.028254556,0.019125698,-0.0065853647,-0.07707088,0.016902916,-0.014607425,-0.037221543,0.017322233,-0.07018542,-0.05518245,-0.03918009,-0.08410847,-0.045043252,-0.045543436,-0.02400248,0.018057728,-0.042953074,0.034758087,0.0665627,0.0063181343,0.0046685105,0.016531399,-0.0393366,0.054468997,0.09167885,0.018649163,0.00981005,-0.0956861,-0.030095743,-0.098539844,0.038226902,0.02556254,-2.8717238e-08,0.12236399,-0.031240566,0.07266099,-0.029844798,0.11823077,0.037913322,-0.02145362,0.087590426,-1.3577398e-05,0.04152493,-0.007144886,0.033555165,-0.024574038,-0.037721284,0.053778708,-0.03601319,-0.028187629,0.03639077,0.0057005743,0.022026096,-0.055018857,0.026989039,-0.053765014,-0.00696545,0.00428955,-0.049324468,0.0068477155,0.073956355,-0.042933486,-0.031088257,-0.009169776,-0.0020468293,0.027695166,-0.02773953,-0.040932782,-0.0024877295,-0.073655866,-0.038918868,-0.076048516,0.05676632,-0.023177074,-0.16466457,-0.06798263,0.0087063145,0.045477685,0.029981667,-0.035168674,-0.03297626,0.008083231,-0.033482548,-0.020663135,-0.062274475,0.008113851,-0.052221905,-0.025704913,0.06123038,-0.030799987,-0.13166307,0.0040645846,-0.06483694,0.10522406,-0.02266154,0.15243414,0.007957147 +3.6.1.5,"Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyse NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. They differ from ATPases, which specifically hydrolyse ATP, by hydrolysing both ATP and ADP. The eukaryotic enzymes requires Ca2+, but Mg2+ can substitute. Most of the ecto-ATPases that occur on the cell surface and hydrolyse extracellular nucleotides belong to this enzyme family.",384,1.0,-0.052674808,-0.064359985,0.03603647,-0.076184444,-0.01241533,0.010012659,0.013373635,-0.03151959,0.022053538,0.03236753,-0.009785417,0.028437844,-0.04854022,0.05313535,-0.03352874,0.072104104,-0.015273931,-0.009421166,0.06485962,-0.014770697,0.064776964,-0.03286526,-0.029351668,-0.018709585,0.009578016,0.0726504,0.030282188,0.08782123,0.020011766,-0.052020434,-0.09224989,-0.11201197,0.0052164504,-0.06724201,0.0009326899,0.10876539,-0.06443299,-0.00915094,-0.047524106,-0.0338684,0.08534079,0.00063524686,-0.014235253,0.04982588,-0.03607217,-0.052473262,0.047796443,0.0045565753,-0.013872723,-0.0033924845,0.039714884,-0.05554719,-0.041635156,0.0072495034,0.014591349,0.038941737,-0.05413896,0.0415511,0.03589072,-0.04900479,-0.013347759,0.03164408,-0.04223559,0.049108036,0.033441786,-0.024907408,0.06851451,-0.012996098,-0.032413017,0.009453846,-0.09013144,-0.04645704,-0.05439195,0.015101065,-0.025251318,0.033489555,-0.021228615,-0.079316355,-0.032166135,-0.0007269591,0.025879081,0.008761044,-0.01024493,-0.010086911,0.033125497,-0.032553516,0.003383355,0.048897527,0.04365797,-0.09545599,0.0023153282,-0.015607358,0.04265981,0.033375487,-0.061195266,0.041031092,0.051044278,0.06794856,-0.06277323,-0.051898554,0.0048534004,0.08725575,-0.054730307,0.013314626,0.010631605,0.035684798,-0.0034796954,0.041129265,0.011650043,0.07416285,-0.05810207,-0.004711674,-0.0028382314,0.046730883,-0.009640402,0.031627152,-0.08795156,-0.04023503,-0.018695636,0.010844386,0.042941317,-0.053127453,0.03863224,0.044108514,0.0018229809,0.019778194,-0.074482515,3.712833e-33,0.052145023,-0.051267575,0.050527282,-0.022996735,0.04726255,-0.017243564,-0.07048002,-0.029977446,0.005823415,0.004765253,-0.030838324,-0.047423057,0.05270248,0.02844653,-0.05090343,-0.04787167,0.030582953,0.03810596,0.070925705,0.054960612,-0.030949924,0.05883746,-0.036775146,0.010464207,0.036162432,0.05857788,-0.07354509,0.05343616,0.09495987,0.009639201,0.058670435,-0.11559624,-0.13598171,0.007372881,0.046059366,-0.015321127,-0.028856022,-0.040789142,0.05686972,-0.057872336,-0.09746643,-0.036112152,0.0059205974,0.0049310103,0.043506872,-0.07971572,-0.08357579,0.025761541,-0.05028291,0.0028529747,0.076324046,-0.046855655,0.050523,-0.0044128285,-0.036338247,0.02452435,-0.036675088,-0.01657129,-0.029226867,0.060688823,0.0115084145,0.02872973,-0.014359562,-0.021437371,-0.028797688,0.03878686,-0.049068905,-0.09434705,0.06324744,0.081983775,-0.020338636,0.015428484,0.078439504,0.026443819,0.031165522,-0.025163965,0.07466073,0.012559914,-0.030347057,0.066041775,-0.028603077,-0.10788917,0.048405375,-0.008358765,-0.029220458,-0.07284113,-0.013224166,0.017163327,0.047597952,0.039521676,0.07104483,0.056613084,-0.08414814,0.0024346716,-0.0023715252,-5.4501145e-33,0.06822505,-0.014347096,0.041967534,-0.08111587,-0.0425331,0.020182004,0.07034867,-0.043139327,0.0344177,-0.053425968,-0.013567034,0.022359988,-0.07194985,-0.086277016,-0.0049620573,0.02565913,0.0057366365,0.10933145,-0.007587138,0.016513873,0.019732669,0.124314226,0.011543993,0.05443476,0.047635783,-0.037873935,-0.0020689173,0.0027135324,0.04113966,0.049774077,-0.026597368,0.039507378,-0.030195594,-0.05479419,-0.03435666,0.0055373446,-0.032580964,0.009812133,-0.0298576,0.052211724,0.08682589,0.08689485,0.0036707052,0.028597964,0.037720133,0.13726121,-0.02061041,0.098002434,-0.028806482,-0.084222354,0.012467061,-0.024336891,-0.013277026,0.08167199,0.086441755,0.005116503,0.039917033,0.033904117,0.043853782,-0.068788044,-0.04280339,-0.0504211,-0.014253442,-0.056221563,0.033620235,0.045010373,-0.025438987,-0.012259303,-0.024919022,0.010171505,-0.008558864,-0.02309023,-0.023703033,-0.02238756,-0.018900411,0.048098676,-0.06961021,-0.05993908,0.014820709,-0.0704422,-0.013981108,0.1310706,-0.023810824,-0.07528905,-0.008604337,-0.0573392,0.019278707,0.008165742,-0.011391303,-0.005926354,0.024911825,-0.05312412,-0.026118781,0.084425986,0.060868945,-4.085945e-08,0.02798278,-0.016066622,0.035281576,-0.08981193,0.0061406293,0.049281877,-0.014786269,0.07868432,0.16241497,-0.03939814,0.010921456,0.06302548,0.023792824,0.023588516,0.037893996,0.038108055,-0.00878588,0.011776544,-0.060564168,-0.03924236,-0.09743617,0.030708242,-0.11660962,0.11123777,-0.010147052,0.0024322737,0.009634537,0.0044091246,-0.020418381,-0.02978316,0.049950104,0.014674831,0.023952518,-0.04244157,-0.069290064,0.022876447,0.009425752,0.017322566,-0.012722393,-0.017952913,-0.08759115,-0.1448693,0.011390211,-0.018069362,-0.015763905,0.027293144,-0.0047264015,0.009106117,-0.04847337,-0.016687408,0.075224176,-0.074003406,-0.00851189,-0.17716545,-0.08224628,-0.019476885,-0.012190648,-0.07831378,-0.019971428,-0.06812758,0.02124097,-0.010625802,0.20473701,-0.031916834 +3.6.1.6,"The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate. Specificity depends on species and isoform.",384,1.0,-0.0006649551,-0.08208617,-0.06642186,-0.088319644,0.047723204,-0.03387204,-0.02010337,0.021425992,0.016827982,0.056150578,0.009524727,0.0074308454,-0.12261687,0.10601229,-0.037650045,0.034208022,-0.021931328,0.021722842,-0.0026219438,-0.010559579,0.17248286,0.05374255,0.05006192,-0.0030565034,-0.035902657,-0.006081418,0.017918017,0.054509174,-0.03613628,-0.122039646,-0.054084018,0.017221486,0.006777862,-0.017798627,0.07830727,0.09454449,-0.06588773,-0.003667588,0.0485304,0.050295915,0.05836173,-0.01984111,0.012600226,-0.061521653,-0.06693572,-0.025720166,-0.059716273,0.033858236,0.08782369,0.037518058,-0.049028303,-0.0776486,-0.045821626,0.037421934,-0.030272305,-0.006588745,0.012980187,-0.04330443,-0.060882818,0.0028726563,-0.028245414,0.0012009955,-0.038071543,0.012659763,0.12433408,-0.0020864154,-0.038331103,-0.027788928,-0.0141360015,-0.06920087,0.006429189,-0.0837373,-0.0080460915,0.0016368518,0.01447836,0.027923366,0.016524639,-0.025307462,0.038475044,-0.072621435,-0.008778802,0.016469363,0.01176724,-0.049135942,0.019899828,0.017890591,-0.032597803,0.026053736,0.07681764,0.0017761455,0.02749932,0.037502237,0.034237165,-0.04082736,-0.04315472,0.042628475,-0.004306059,0.075095765,-0.005185746,-0.03950525,0.11424289,0.020299299,-0.069614515,-0.02600004,-0.030769276,0.042913646,-0.010978621,0.0151664475,-0.08029977,-0.024939258,-0.036801133,0.024292082,0.075572915,-0.0063229594,0.021680525,0.06444504,0.034315143,-0.020152513,-0.008130293,-0.015616867,-0.029744748,-0.03479171,0.05886313,0.041307427,0.008689565,0.1245882,-0.14874865,2.022455e-34,0.07120177,0.046077825,-0.0172016,-0.026969282,-0.012641523,0.030963857,-0.052353006,0.006905267,-0.1116135,-0.005379034,-0.08791285,-0.038336568,0.06795098,-0.070453905,-0.021873085,0.010861347,0.04251852,0.039353523,0.04541755,0.029283477,0.059452012,0.06651415,-0.07776899,-0.01004474,-0.022201506,0.058720686,-0.06650722,0.054432362,-0.013016609,-0.023002725,0.0039604735,-0.06676535,-0.084212385,0.04111122,0.101507336,-0.013765621,-0.025303483,0.004578663,-0.017852062,0.008165785,0.023469646,0.017993603,-0.0081561515,-0.013466272,0.03163004,-0.053870894,-0.087660104,0.07254221,0.031529576,0.037700247,0.076148584,-0.08333629,0.091934346,-0.031062283,-0.03835407,0.045794416,-0.038933024,-0.0011397086,0.07113964,0.02802515,-0.0072947782,-0.037066627,-0.0706738,0.04838861,0.040498592,0.03104134,-0.054245338,-0.061041873,0.013616665,0.13527301,-0.06768858,-0.05273164,0.01369198,0.026522765,0.0023719277,-0.05242068,-0.04992249,-0.06569294,-0.009332474,0.06883145,-0.023067107,-0.026964756,-0.05255907,-0.02985959,-0.07950352,0.009926773,0.027932098,-0.10522282,-0.041271396,-0.036072418,0.12242646,-0.08737933,-0.04559876,-0.019986004,0.06822327,-2.8253479e-33,0.06247061,-0.014657023,0.0142887775,-0.056309976,-0.06984565,0.006631783,0.02061314,-0.07724782,-0.03138773,-0.01863954,0.03534805,-0.028753534,0.0019145719,-0.049025126,-0.06948159,0.079125024,0.0007450147,0.012458842,0.075784646,0.01894264,-0.06847465,0.06710518,0.063977815,0.07849785,0.013488157,-0.016096093,0.018312048,0.045104537,0.036969393,0.008675122,-0.019333493,0.061072156,-0.02012067,-0.059109945,-0.027445013,0.04995113,-0.09103989,-0.0255236,0.08395977,0.04779061,-0.027982356,0.045314085,0.031105315,0.09514501,-0.016742583,0.055153947,-0.06676859,-0.0042154496,-0.04978651,-0.086950906,-0.0022614845,-0.00902576,0.041304085,0.013809545,0.05451248,0.033598743,0.01108717,0.05747974,-0.02932642,0.02195493,0.028224027,-0.051343273,-0.020710949,-0.040818103,0.06866884,0.08064374,-0.03765346,-0.043243784,0.026935691,0.030699177,0.024897018,0.0056208344,0.011842947,-0.0029551014,-0.055109583,-0.0062769833,-0.08046165,0.0064018746,-0.019802017,-0.0012391062,-0.016529884,0.054371014,0.0020163858,-0.081995316,-0.074008,-0.09679534,0.021959357,0.13624965,-0.02102914,0.08790046,0.020855477,0.01462178,0.027613215,0.032424625,0.051282857,-3.4315732e-08,0.04929875,-0.004142751,0.03723721,-0.08602313,-0.01299288,0.027271379,0.0068528606,-0.040939867,0.11003036,0.023822006,-0.04066496,0.092020534,0.037045788,0.06809776,0.100056164,0.029261243,-0.04300017,0.016156297,-0.06798113,0.0013946947,-0.009292198,0.012334196,-0.13222075,0.021166468,-0.023473628,-0.040449113,0.040165283,0.053478587,0.03183679,0.011515933,-0.016398134,0.04309512,0.044785395,-0.11890602,-0.044331204,0.056462046,-0.027776599,-0.015814243,-0.04237988,-0.0052866465,0.016270047,-0.088546775,-0.09759253,0.006868511,-0.07174392,0.0043566767,-0.027381422,-0.004078127,0.011867876,0.0064613214,0.022810385,-0.0010329529,-0.0009770468,-0.05020941,-0.06838684,-0.010458771,-0.018799627,-0.021410063,0.016217308,-0.048269656,0.026354183,0.0004686298,0.09624631,-0.06265762 +3.6.1.8,"Also acts on ITP, GTP, CTP and UTP.",384,1.0,-0.02380733,-0.07471108,0.075151205,-0.077846125,-0.0043164245,0.05066076,0.022800172,-0.021566287,-0.011332477,0.026538992,0.020294614,0.05575894,-0.034593817,0.09837048,0.006598853,-0.037267014,0.028430495,-0.082984254,0.07374585,-0.021602102,-0.03796293,-0.053561185,-0.043475635,-0.032157294,-0.0044697775,-0.007254303,8.87242e-05,0.020185046,-0.01607078,-0.10320882,-0.06900996,0.01407296,-0.0026577215,-0.0014271161,-0.029892864,0.07178314,0.019114466,-0.04298471,-0.023210356,-0.015637698,0.06864796,-0.018031677,-0.005388817,0.033958115,0.07885091,0.029001988,0.009319307,0.0073645986,-0.030926174,-0.046742145,0.03869832,0.07898898,0.030257436,0.08258273,-0.0680609,-0.04669351,-0.015112031,-0.004621696,0.0068679494,-0.0029365036,-0.102996476,0.0040528136,-0.044115745,0.042350482,0.055931706,0.11698925,-0.015073527,-0.0017727205,-0.030267248,-0.043905746,-0.09227639,-0.007805146,-0.062366195,0.08018223,0.029541826,0.033498462,-0.016780954,-0.010708317,0.014418271,-0.048412126,0.0025271378,0.05610418,-0.0046055987,-0.0055135423,0.08481125,-0.020274978,-0.0439001,-0.014995073,-0.03794342,0.032077443,0.0030366466,0.016993253,0.04951028,0.04944745,0.015102162,-0.0136532085,0.0013646691,-0.0562849,-0.050310496,-0.016402157,-0.02945263,-0.00037231777,0.040354196,0.008106438,-0.055921726,-0.023437949,-0.000988882,-0.03966889,0.006439373,0.0012391446,-0.0042184084,0.014380748,-0.037652187,-0.034805,0.033371605,0.046737164,-0.11669159,0.014980873,0.0070982166,-0.030352654,-0.032640725,-0.095581874,-0.06130967,0.086063296,-0.054708738,0.051277045,-0.03146684,-5.7026225e-34,0.0050354176,-0.010497836,-0.031808514,-0.043034688,-0.01449893,0.016171375,-0.0123868035,0.0057874895,-0.0059260684,-0.0451117,-0.068877175,0.0039792494,0.029751796,0.017579101,0.008819906,0.0050411783,-0.06824988,0.09410764,-0.017690076,-0.06286648,0.038569707,0.13418193,-0.045440648,-0.018501747,0.042200167,0.06598006,-0.13274561,-0.057540324,0.06102125,0.008279871,0.06067973,-5.905422e-05,-0.07623551,0.12873514,0.040387735,0.12131723,-0.04174001,-0.05587662,-0.0022815908,0.021493994,0.023392642,0.018331602,-0.06629074,0.00028486326,0.041959077,-0.06610354,-0.023367332,-0.09917557,-0.056103278,0.01931561,0.027538717,0.034137152,-0.022097493,-0.05032958,-0.004009263,0.02360259,0.024758939,0.01595077,0.060470816,0.092896566,0.0624101,0.047359522,-0.0023506244,-0.038599703,-0.036005184,-0.0012261887,-0.028338557,-0.098917216,0.052127715,0.076157175,-0.04203519,0.033827297,0.13669214,0.039716277,0.01851003,-0.038373157,-0.06046222,-0.01416613,-0.019041797,0.10551669,-0.09095433,-0.12666968,-0.011422611,0.00049110194,0.027732247,-0.00045418052,0.04436068,-0.08126504,-0.04305079,0.02500124,0.010750446,0.0225972,0.018987257,0.09806088,0.018919395,-1.1914211e-33,-0.06542179,-0.06058169,-0.022636564,0.06962234,-0.058717467,0.009816197,0.061102025,-0.06745162,0.05031687,0.07675191,0.054976247,-0.0464312,0.024922855,-0.0077443514,0.07213972,0.007334488,0.09804519,0.06264365,-0.061550815,0.01580589,-0.015796749,0.04385125,0.011948272,0.072670795,0.019266455,0.06580716,-0.02722049,-0.035510093,0.05965111,0.00497181,-0.022283513,0.09033291,-0.11699627,-0.03628692,-0.0075005814,0.0029422946,-0.0463515,0.09292617,-0.031267114,-0.050120566,0.14851642,-0.032287814,0.016986933,0.091691494,-0.035795495,0.05876217,0.020587293,0.023711748,-0.11769011,0.043329965,0.05082651,0.019056898,-0.042053785,0.020189751,-0.0020504736,0.062116206,0.07620405,-0.067889586,-0.08848616,-0.043397415,0.057859465,0.010420799,-0.03795458,-0.03621923,0.066032,0.006645613,0.01829103,-0.022274265,0.049787115,0.016673816,0.019809518,-0.042340025,0.017202396,-0.11874014,-0.075987,0.00032280426,-0.06260579,-0.031712033,0.0050872136,-0.062174525,-0.043296516,0.011457198,0.04156821,0.031605013,-0.05275046,0.029500335,-0.015879793,0.026513482,0.06065251,0.033562474,-0.058477063,0.067517765,-0.027831186,0.015699893,-0.085362114,-2.1368821e-08,0.031869125,0.005308684,0.028044136,0.021828236,0.00298843,0.006270118,0.020935103,0.04739127,0.005538696,0.004770227,0.040629078,-0.043775775,-0.050218925,-0.09890978,0.16288587,-0.042202104,0.009489075,0.06505111,-0.06718409,-0.025097962,-0.09230271,-0.018806837,-0.002370921,0.04356225,-0.04378122,0.067136675,0.015837414,0.005775146,0.10621263,-0.02314919,0.0060676984,-0.07070607,-0.057895195,-0.036213145,-0.03774053,0.06860763,0.054019876,-0.0934147,0.0046782293,-0.020799626,0.0012797985,-0.094046734,-0.021290844,0.047806617,-0.026537996,0.052270275,-0.011735016,-0.09068654,0.03546497,-0.059653815,0.020815061,-0.025744429,-0.00937365,0.0255774,0.038765177,0.04033035,0.04630409,-0.11448016,0.020017836,-0.00033686374,-0.012128351,0.019752996,0.05174637,0.02572737 +3.6.1.9,"The enzyme preferentially hydrolyses ATP, but can also hydrolyse other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD+, NADP+, FAD, and CoA.",384,1.0,-0.04563469,-0.03526414,0.012993837,-0.051796164,0.0020605347,-0.009974835,-0.04710992,0.0058409525,-0.006879233,0.006427807,-0.039028578,0.01657187,-0.10096577,0.09141166,-0.037873402,-0.056687076,-0.034271076,0.038787723,0.05712027,-0.051602576,0.09651665,-0.00640154,-0.05498132,-0.010406767,0.06747233,0.03456492,0.07640432,0.018577477,0.023800924,-0.04557132,-0.10701698,-0.022075154,-0.020075629,-0.04302902,0.001963162,0.17571147,-0.08193879,-0.011420473,-0.012708293,-0.011909287,0.094264895,-0.022462303,-0.03168673,0.012476412,-0.051457975,-0.042327933,0.014803351,0.0389687,-0.013163273,0.01038073,-0.0025847673,-0.0076630716,-0.007288304,-0.04830336,-0.017639063,0.016528409,-0.004837385,0.00063264824,-0.033328455,-0.008409625,-0.04175473,-0.023787864,-0.015653659,0.047603,0.124237835,-0.06968114,0.050584454,-0.002961327,-0.012808783,-0.034409363,-0.01835615,-0.034305558,0.0012125244,0.011867753,-0.06348283,-0.01455918,-0.055904616,-0.01360827,0.046919104,0.011667486,0.049203146,0.026244313,0.026700508,0.030212017,0.073366,-0.021570677,-0.029050669,0.040996023,0.024311272,0.016029932,-0.013641426,0.0038915367,-0.023712888,-0.012455383,-0.058884073,0.023418969,0.0023549765,-0.017089836,-0.05888169,-0.06781583,0.07364234,0.09972056,0.021229269,-0.020561304,0.0032190324,0.07229857,-0.04031868,0.03628086,0.005454143,0.040771015,-0.05285716,0.019695854,0.036700103,-0.029799419,0.036282472,0.043047246,-0.091149494,-0.046252117,-0.04647602,-0.034955982,-0.035493348,-0.10279976,0.004465813,0.06822879,-0.0063053668,0.06796492,-0.05132339,1.8686582e-33,0.04372596,-0.006906385,-0.06790746,-0.056720242,-0.0048165363,0.016435707,-0.04879753,0.050639212,-0.06593076,-0.05203049,0.014870958,-0.030884586,0.046373993,0.0034088683,-0.018495237,-0.0016673713,-0.035487503,0.0511952,0.074691065,-0.00084476016,0.01538816,0.09140649,-0.019504175,0.024682267,0.017226087,0.056240972,-0.12231601,0.025335278,0.053520244,-0.005675266,0.01531564,-0.09297185,-0.11709267,0.040756058,0.06039459,-0.015196555,-0.078142,-0.035421547,0.027597189,0.033657324,-0.06724557,-0.031371817,0.018316526,-0.04574458,0.013539261,-0.035064857,-0.04259282,0.028211404,-0.023660786,0.038514577,0.08395361,-0.049774945,0.06639069,-0.056445472,-0.03720661,0.022497434,-0.012686535,0.01403833,0.0059870365,0.061921827,0.0526054,0.018396713,-0.0048582596,0.037697196,-0.045820195,0.057403784,-0.054241654,-0.10147716,0.07463305,0.120988265,-0.06697304,0.05328817,0.067339316,0.0012095524,0.01482832,-0.040957257,0.08081073,0.025356304,-0.009195652,0.07825542,-0.0027303684,-0.07907185,0.00069640315,-0.0072009475,-0.0005032759,0.022548655,0.06373868,-0.070339985,0.0041012866,0.010937166,0.10179594,-0.031212624,-0.06547309,0.005589075,0.024756068,-4.1839143e-33,0.122776695,-0.08236516,0.010271928,-0.10806363,-0.08357477,0.047164705,0.065125674,-0.1287398,-0.03510014,-0.07246667,0.01581193,-0.0036005399,-0.03628991,-0.05822928,-0.03845671,-0.0077992203,0.00711809,0.09374037,-0.0148666,-0.013867028,0.020734362,0.13266937,0.036448345,0.036813445,0.08330005,-0.059288032,-0.02603737,0.02945019,0.07338331,0.032283515,-0.027282793,0.056932554,-0.06669735,-0.015933039,-0.004194624,0.055473786,-0.028693382,0.04788162,0.023895925,0.039763357,0.05479627,0.09585965,0.025241347,0.026916772,0.010607425,0.052768417,-0.059192337,-0.01598409,-0.056566168,-0.07005516,0.03728356,0.006414095,-0.04514983,0.069885805,0.013963467,0.03203426,0.028254667,0.021735892,0.02000104,-0.044581693,-0.06435888,-0.06622752,-0.007290832,-0.0013170954,0.0015421417,0.044629097,-0.054238226,-0.0063471072,-0.050717182,0.09527565,-0.028721567,0.0136071555,0.044926364,0.04715091,0.0072799213,0.028002646,-0.029465757,-0.0024472275,-0.033358905,-0.10278685,0.013944368,0.11550143,-0.07559815,-0.054637276,-0.026261123,-0.051348593,0.015713738,0.086230464,0.024204792,0.028233346,0.02344986,-0.0095226625,-0.057305403,0.01759943,0.046856213,-3.749063e-08,0.0030623807,-0.041967046,0.04201145,-0.0787476,0.027672194,0.03642564,0.005551377,-0.0036329394,0.08356209,-0.040985957,-0.022034356,0.069276474,0.0042460808,-0.016143551,0.07466026,0.0105600525,-0.06698195,0.040505666,-0.042207584,-0.05543143,-0.033212855,-0.0016294298,-0.13430639,0.13656111,0.0016978128,0.03645952,-0.0068577174,-0.0181578,0.026862755,-0.023548463,0.003909214,0.0189551,0.020347401,-0.063575506,0.012051027,0.058647975,0.0036339096,-0.0042771404,-0.09844951,-0.005804725,-0.048450653,-0.08541524,-0.036531996,0.014520134,0.015991611,0.03347289,0.0029575292,-0.039311968,0.005853116,0.01893058,0.040718112,-0.026598634,-0.024066636,-0.1018328,-0.03575001,-0.03060377,0.005206057,-0.09822692,-0.068813406,-0.02586414,0.019514382,0.071328335,0.20424336,-0.101770945 +3.6.1.10,The product contains 4 or 5 phosphate residues.,384,1.0,0.012186792,-0.0462243,0.016808249,-0.1054336,0.06743004,-0.0076045725,0.124106504,0.10038407,0.017984934,0.02465738,0.013480722,0.010463299,-0.031469107,0.037420504,-0.09194594,-0.008796655,0.02061199,0.048193082,-0.059821326,-0.047193464,0.16287422,0.05362713,0.007573928,0.0148979165,-0.009619784,0.07373082,0.008529537,-0.01918501,0.07497811,-0.06749488,-0.043113884,0.01742806,-0.0016826097,-0.1056126,0.047401253,0.057885576,-0.06970876,-0.04382846,0.031448774,0.064889595,0.09635269,-0.04359141,0.0046970025,-0.009153236,-0.016545733,-0.005936442,0.008732998,0.02798356,0.067517325,-0.040381633,-0.043612592,-0.044152413,-0.08675306,-0.009240122,0.016833823,-0.13506374,-0.042962596,0.03874879,-0.086459614,0.10455253,0.01995987,-0.040797707,-0.038348824,-0.03466565,0.07499307,0.009970193,-0.010993164,-0.1252239,-0.049489696,0.010054609,-0.057963967,-8.151506e-05,0.08083436,-0.0008449299,-0.06852343,0.03571645,0.008011678,-0.07674607,0.03495456,0.0009991035,0.013548947,0.014017223,0.0009380034,0.04498209,0.034033168,0.04032698,-0.066274896,-0.014047143,0.032400202,0.0075937794,0.004601949,0.02594599,-0.00073516037,-0.054312713,-0.031064661,0.05361913,-0.039301798,0.008132253,0.051261727,0.02874358,0.0069483467,0.007353483,-0.017506307,-0.09637052,-0.06225869,-5.9181566e-05,-0.01866879,0.02463979,0.004909835,0.051076777,-0.09838681,0.035194125,-0.0014128566,0.056597,-0.024490464,0.013579689,-0.0019021799,-0.039557587,-0.04882396,-0.022844914,-0.008754193,-0.034198396,0.106150635,0.007368307,-0.088882655,-0.004290822,-0.034832284,-1.9322275e-33,0.008691164,0.06971784,0.06612993,0.032213353,-0.07153044,0.05642408,-0.025699118,-0.051919464,-0.015633825,0.008531382,-0.04142829,-0.044172604,0.02756465,0.006064372,-0.0012646262,-0.033465024,-0.01727509,0.07261737,0.1297187,0.014327021,-0.002424857,0.031034842,-0.10788519,0.07772775,0.0048210504,0.027484098,-0.06934787,-0.021138014,0.01335615,0.018005552,0.058776688,0.022494847,-0.07453147,-0.077233896,0.010136812,-0.0699586,-0.03652484,-0.036600206,0.009364094,0.0014895361,0.027099993,-0.0254532,0.03595729,0.07275471,0.026885562,-0.08048853,-0.051281493,0.07035574,0.03152962,0.03096967,0.004792428,-0.00030332908,0.074455835,-0.029977927,-0.056283962,-0.011905755,-0.04954899,-0.026231084,0.04450487,0.06670837,0.02331944,0.08751367,-0.062738724,0.015059773,0.046554428,-0.00019049269,-0.027869847,-0.026958562,0.07072952,0.08183467,0.041923508,-0.044522453,0.0901708,0.0355874,0.0027138856,-0.025540717,0.0416507,0.06367432,0.0059941937,0.07687506,-0.00756164,-0.037577465,-0.0057293936,-0.035086337,-0.059164558,0.0382651,0.05923018,-0.07010086,0.016654072,-0.049257904,0.11838115,-0.112690575,-0.069299355,-0.04933954,-0.09093173,1.5491877e-33,0.115201354,-0.021089448,0.011218474,0.009767577,-0.029401984,-0.036644824,0.08573383,-0.0371537,0.05054998,0.012324002,0.06960335,-0.012757754,0.06206013,-0.005599442,-0.012393898,0.14609584,-0.03244284,0.03672441,0.06248246,0.011247352,0.006088322,0.008050028,0.06283086,0.098429985,0.035321977,0.023836939,0.026615359,-0.10120717,-0.004946227,0.032398716,0.008135532,-0.063269615,-0.038758863,-0.021044472,-0.09544613,-0.1084535,-0.034628615,-0.05595746,-0.0023542435,-0.008309482,0.04370005,0.009851886,0.09002951,0.031422183,-0.075224236,-0.03737127,0.05237738,0.04951208,0.012510739,-0.03550746,0.052398566,0.026578605,-0.091726,-0.061200313,-0.0019509217,0.039909355,0.036811016,0.018004848,-0.030348761,0.01086297,0.010748632,0.010039854,0.0082329,-0.04956324,0.06834579,0.069865294,0.031141937,0.001971982,0.015963096,-0.019425835,0.025140833,0.023173733,0.06278488,-0.03775125,-0.030552994,0.004697679,-0.072413996,0.041519333,-0.0067142816,-0.0033424678,-0.07122732,-0.007807871,-0.059770517,-0.04717985,0.012602372,-0.06113483,0.022593042,0.0810925,0.01658478,0.019102272,-0.044056114,0.0071123024,0.022719517,0.090447284,0.09493768,-1.7927766e-08,0.06072463,-0.015911808,0.01905002,-0.048772264,-0.033491988,0.030828886,0.01052393,0.029407535,0.05212491,0.03606343,0.045439117,0.03568603,-0.07959641,0.026148066,0.06403887,-0.008178746,-0.065081164,-0.002443796,-0.038769275,-0.08313392,-0.023876185,0.022683779,-0.04583783,-0.023666004,-0.012011157,0.020564446,0.040111393,0.008853487,-0.020940527,0.002662028,0.05102984,0.013001755,-0.07671952,-0.08434725,-0.0039596357,0.049410224,-0.008411071,-0.033091813,-0.041379035,0.08237444,-0.087351106,-0.117095694,-0.02987468,0.018022357,-0.02599972,0.057578847,-0.085161,0.024215188,-0.01785187,0.021221995,0.00016154634,0.015898742,-0.054327924,-0.029943973,-0.019151933,-0.0016006621,0.073251314,-0.07027572,0.025617747,-0.06165172,0.0077727255,0.058532014,0.15274891,-0.04970574 +3.6.1.12,"The mammalian enzyme also displays weak activity against dTTP and dATP, but none against dGTP. Activity is highest with analogs including 5-iodo-dCTP and 5-methyl-dCTP.",384,1.0,-0.09690962,-0.0886508,0.049576066,-0.04933326,0.029400563,-0.027717697,-0.018866314,0.11629588,-0.0013976654,0.05056125,-0.069921814,0.06552794,-0.11550705,0.1051324,0.031016199,0.055598512,0.051451072,0.016625166,0.064101934,0.0024694442,-0.0399231,-0.014663613,-0.019508721,-0.025695678,0.007729258,0.019902814,0.029862858,0.0030771873,-0.033814542,-0.042975612,-0.08066856,-0.0397546,-0.09534532,-0.0026780374,-0.0005751241,0.04008749,-0.07161591,-0.011623354,-0.0065591056,-0.032730088,0.08902226,-0.021544524,-0.030925686,-0.05339048,0.01439681,-0.04853705,-0.069981314,-0.011286732,-0.06873997,-0.0033248477,0.04729607,0.02066863,0.052061953,0.045633946,-0.04008549,-0.034727827,-0.04413217,0.04435061,-0.044830985,0.0002442378,-0.0068103694,0.044513106,0.0144743435,-0.043886475,0.097973585,0.025355708,0.0054948153,0.0390504,0.018438835,-0.007917596,-0.07848459,-0.025265371,-0.06467113,0.046620026,-0.0019410142,-0.013527705,0.02149563,-0.081830524,0.119988315,-0.09868993,0.024304308,0.09981295,0.01796221,0.054563534,0.03468493,0.05170875,-0.013591124,0.0903706,-0.0086436635,-0.01680191,0.022547796,0.04855542,-0.09466289,0.0506582,-0.064372644,0.015370886,-0.016750801,0.011231586,-0.076563925,-0.033890042,0.009839205,0.08660113,-0.10875409,-0.031714514,-0.0300603,0.009776838,0.034612633,-0.04293714,0.0111992555,-0.046465784,0.0014990956,0.055440802,0.002908754,0.06302149,-0.029648338,-0.007458281,-0.06709861,-0.036973093,-0.019168586,-0.034822486,-0.04336671,-0.06882575,-0.019923402,0.08060236,-0.0039626695,0.019046001,0.019984752,-8.8324e-34,0.07149642,0.005375968,-0.022277622,-0.04043486,0.041260507,0.008530179,-0.035602864,0.024452174,-0.035600122,0.052655414,-0.08363723,-0.075483635,0.022783324,0.05172993,-0.01438472,-0.008768207,0.0039975606,0.074170135,0.0742325,-0.08055826,0.05843969,0.07966775,-0.057178672,0.020293565,0.04245154,0.046370186,-0.099696614,0.056496017,0.009214576,0.014325616,-0.081636876,-0.14298141,-0.010579851,0.082659595,0.003676856,0.024706375,-0.033893228,-0.04073684,0.0070649395,0.037471026,0.04153822,0.0036789048,-0.022862582,-0.031850386,0.018435506,0.018999003,-0.027218042,-0.05436982,-0.10609096,0.017057585,0.0453433,-0.039953094,0.031157747,-0.06379364,-0.027522253,-0.025591817,-0.10355181,-0.031817988,0.08135954,0.10798706,-0.012350027,-0.0055355546,-0.049556337,-0.018591952,-0.0056240982,-0.00075700966,-0.06591411,-0.085057795,0.04697397,0.08291952,0.0013743277,-0.008890301,0.08084791,-0.045673925,0.06529099,-0.008311449,0.043975793,0.09586679,0.029526865,0.049538124,-0.04406553,-0.06476116,-0.0154068945,0.002431476,0.025234038,0.04110157,0.01786482,-0.050987773,-0.01107645,-0.010558814,0.08941975,-0.035442717,0.002703288,-0.047280118,0.016862698,-8.769219e-34,-0.0119392555,-0.019625196,0.030189443,-0.055075344,-0.05512455,0.064032786,0.013509637,-0.103680305,0.09039925,-0.016382156,0.14004171,-0.036087427,-0.058294598,-0.047623117,0.0446841,-0.021974115,-0.0496464,0.08217456,-0.007881636,-0.002537988,-0.008517853,0.04756921,-0.04472349,0.106363826,0.07457612,0.0061700516,-0.035658624,0.013809665,0.088523455,0.00344067,0.03906272,0.07149464,-0.05117969,0.024843803,0.087282866,0.02031712,-0.017483316,0.033173617,-0.052659623,0.026964009,0.03656015,0.050352193,-0.024007788,0.079823256,-0.016896367,0.05137535,-0.10945509,-0.009783869,0.01326037,0.004913766,0.07806771,-0.03509596,0.02468088,-0.040206812,0.013208356,0.052458964,0.12852338,0.007360273,-0.048044093,0.023355959,-0.042272955,-0.027134327,-0.017690487,0.032168344,0.022306764,0.08059326,0.004613106,0.028662086,0.016817683,-0.03369135,0.03523512,0.049814,0.039274726,-0.040422894,-0.07837238,-0.0007018439,-0.028166091,0.012690765,0.0743636,-0.008390126,-0.033789504,0.03004264,-0.03407058,-0.08735439,-0.0810127,0.026568485,-0.08641765,0.10160757,0.040339276,0.05996805,-0.06536919,-0.022257062,-0.045339875,0.0012122116,0.014410366,-3.1065753e-08,0.08839134,-0.03579436,0.01171005,-0.046796143,-0.046834935,0.03342138,-0.008741889,0.02862126,0.07119458,0.063686624,0.030771205,0.041786343,-0.026972584,-0.017999351,0.051784515,-0.03260553,0.004113629,-0.0124737285,-0.029203672,-0.030140411,-0.06507566,0.021940246,-0.06835863,0.00047094375,0.013907126,-0.017369231,0.053974517,0.04763407,0.090840586,-0.08282053,0.04003117,0.02367985,-0.023522174,0.027291194,0.00527367,0.042748738,0.03311342,-0.035880573,-0.09712001,0.10161496,-0.034193568,-0.066432945,-0.02100367,-0.023748474,-0.023790196,-0.02481924,0.04535479,-0.016992847,-0.024898943,-0.056120224,-0.0463207,0.004068246,-0.04182849,-0.088555396,-0.08343441,0.022033364,-0.042765003,-0.08575658,-0.066655636,-0.071258046,-0.00094005116,0.04164026,0.111956015,-0.0032136112 +3.6.1.14,Also acts on inosine tetraphosphate and tripolyphosphate but shows little or no activity with other nucleotides or polyphosphates.,384,0.99999994,-0.044217084,-0.09704281,-0.033285927,-0.024986494,0.017383268,-0.014342652,0.019991567,0.04488342,0.04417394,0.063528664,0.034400597,-0.0047898996,-0.068594724,0.10686945,-0.017047519,0.04386982,-0.01885751,0.012304022,0.08814088,-0.06980498,0.08382298,0.0019095801,-0.023719216,-0.017778719,-0.039857995,0.040219,0.012572178,0.013125072,0.0064906296,-0.048610892,-0.11112941,0.039845355,0.009258647,-0.043784652,0.06474553,0.15397078,-0.053939693,-0.009938119,0.028456097,-0.012232798,0.106067464,-0.051656533,0.0058256877,0.023089822,-0.0113174645,-0.024578733,-0.02093878,0.008546108,0.00037294932,0.0441322,-0.007880932,-0.017907413,0.033149227,0.00043514423,-0.056041148,-0.009841546,-0.103521846,0.038179003,-0.0029717977,0.0046604644,-0.04575694,-0.03074094,0.008052566,0.023678185,0.11031564,0.02168826,0.05788618,-0.02309251,-0.03882281,-0.02541803,0.03901891,0.020748975,-0.01381959,0.06493783,-0.027381288,0.024524108,-0.0053402744,-0.04350713,0.0076316115,-0.02281377,-0.016228884,0.017531045,0.0024734056,0.019393202,0.035306476,0.0019314311,-0.049251646,0.03502035,-0.06779679,0.07896182,0.05307935,0.012322193,0.020870341,-0.038502797,-0.016287077,0.020356357,-0.008162702,0.029036459,-0.0636874,-0.04148337,-0.019543935,0.06080381,-0.096593864,-0.06185197,-0.006010192,0.07397618,0.008392276,-0.07282921,-0.017661795,0.030457594,-0.002787292,-0.013318442,0.07420762,0.031176139,-0.07355925,0.03902309,-0.0059311637,-0.006881415,-0.047627103,0.034725495,0.022206603,-0.11268845,-0.01024153,0.06199533,-0.06138903,0.08354498,0.006892107,2.5604196e-33,0.04792448,0.001885066,0.014295173,-0.012285333,0.005663172,0.07108883,0.020379433,-0.018415822,-0.050817084,-0.011504785,-0.024483277,-0.06867928,0.11506952,0.013962503,-0.017627206,0.01995167,-0.0058373194,0.012016324,0.08290709,-0.037210748,0.007919528,0.085287414,-0.050448805,0.0051287403,0.012436556,0.027852828,-0.12628229,-0.0075134467,0.016837839,-0.03332773,0.063134365,-0.053983778,-0.08883027,0.03299152,0.08672746,-0.024943493,-0.022216653,-0.026907306,-0.03466039,0.0129777575,-0.033188045,-0.01316689,-0.06533506,-0.029284671,0.0019449318,-0.074640825,-0.00531139,-0.011939308,-0.015695125,0.02773138,0.07087925,-0.026866509,0.03169279,-0.11255197,-0.062472004,-0.010412907,-0.0072463457,-0.066767655,-0.014776677,0.06810708,0.045131356,0.007464883,-0.010748597,-0.046090644,0.0038633128,-0.020307483,-0.10766227,-0.0967636,-0.026060544,0.05965067,0.011424093,-0.06381737,0.07554855,-0.023554582,-0.015326006,0.026520958,-0.059492845,-0.0014497262,-0.03519043,0.02242513,0.07272729,-0.13908489,0.11128014,-0.019667445,-0.034330163,0.018843029,0.034290187,-0.065724194,-0.02785041,-0.028222276,0.15159667,-0.06381134,-0.11699609,-0.032459177,0.03446743,-5.569416e-33,0.0016501826,-0.0030230857,0.02161161,-0.06405641,-0.12772898,0.04625742,0.044163145,-0.041302588,0.076146446,-0.020660462,0.098915085,-0.03864867,-0.07875737,-0.03850562,-0.03157145,0.07464924,-0.0074937064,0.11153985,-0.0071113505,0.012244235,-0.044096366,0.11392018,0.033594467,0.12655619,0.041313775,0.021029273,-0.002178218,-0.01899053,-0.014073991,0.04497636,-0.017629452,-3.676401e-05,-0.06785178,-0.06544253,0.024965245,-0.009335629,-0.027812745,-0.079195134,0.01673848,-0.049952477,0.035896897,0.08256584,0.08596783,0.028999355,-0.008279337,0.019894058,-0.022829905,0.026081316,-0.11880797,0.020322585,0.03155004,0.05973429,-0.032542765,0.05785875,0.080836296,0.054421276,-0.031389825,-0.028788406,-0.048522037,-0.024675036,-0.039267648,-0.058277477,-0.07053049,-0.06584063,0.097971685,0.048612982,-0.06406917,0.06697856,0.098167874,-0.038531326,0.02111132,0.029294925,0.006613896,-0.049807347,-0.046580806,0.024160909,-0.05643285,-0.05581857,0.01923867,-0.07311257,-0.049613718,0.0144596975,-0.046353552,-0.051544692,0.0031764416,-0.015849525,-0.013899565,0.075167164,-0.009023301,0.07324665,0.010680532,-0.00027316788,0.0017728028,0.060346104,0.057746947,-2.9808092e-08,0.068595745,-0.020317778,0.06274037,-0.062784195,-0.018809289,-0.05063135,0.07710546,0.03449942,0.034148525,-0.005851077,-0.035455447,0.010859577,0.038301684,-0.004517438,0.15756814,0.015043789,-0.03788721,0.013627852,-0.05939695,-0.048622835,-0.06832687,-0.036650985,-0.101899706,0.097406134,-0.031694952,-0.0034998534,0.07506096,0.042120744,0.05667423,-0.04259191,0.029602418,-0.0494493,-0.013668318,-0.083172575,-0.007630092,0.074469216,0.024724487,0.0044135503,-0.04813677,0.0066231973,-0.121346936,-0.036868636,-0.040456597,0.050594214,-0.042440467,-0.0065680672,0.0118948715,0.03289921,0.00151869,-0.058991883,0.021599073,-0.025483936,-0.03593668,-0.050215468,-0.045480423,-0.03046108,0.0032085162,-0.0016344097,0.03017772,-0.02029055,0.01685724,-0.005851766,0.08232305,-0.047216542 +3.6.1.15,"The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. Also hydrolyses nucleoside diphosphates, thiamine diphosphate and FAD. The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin [5].",384,1.0,-0.06162693,-0.07600531,-0.08424116,-0.012904821,0.08115035,0.08336002,-0.07021989,-0.0069185044,0.010825024,0.036612626,0.05098022,-0.06013107,-0.0016620302,-0.024468476,-0.06331971,-0.008981862,-0.03634,0.006354972,0.044892058,-0.08751976,0.06311526,0.078640446,-0.029480608,-0.011711048,0.0028887966,0.013213902,0.014116158,-0.040435586,0.025463939,-0.051701326,-0.089069776,-0.0045019356,0.09878049,-0.04288389,0.06561632,0.08383685,-0.02339793,-0.089539886,0.038650557,-0.025169337,0.06404045,-0.016489483,0.057188526,-0.06541866,-0.01566259,0.06598801,0.022177223,-0.030386353,0.028502643,-0.045934465,-0.03263093,-0.077984914,0.050550282,0.010763358,-0.008520925,-0.020994134,0.0423489,0.0056506074,-0.009728853,0.03614201,-0.015906539,0.013150122,0.008886585,-0.020703293,0.02640864,-0.02119994,-0.03638087,-0.021228412,0.021055305,-0.0632226,0.022537528,-0.0585896,-0.0055219186,0.014251552,-0.048596617,0.03274421,0.00026734357,-0.06267461,0.0068767616,0.046814,0.0026659127,-0.018450134,0.0214425,0.054762635,-0.0015778613,0.0029064387,0.018389804,0.047561686,0.04570934,-0.009343349,0.052035753,0.047247075,-0.034514077,-0.038002256,-0.051327832,0.04670436,-0.047433298,0.005290703,0.013962867,-0.088411786,0.038349163,0.03983148,-0.047292396,-0.09297946,-0.036354132,0.030301876,0.0109376535,-0.010061453,0.032616805,0.032067142,-0.043543927,0.017380083,-0.024175674,-0.025890708,0.0019918997,0.01552951,0.056707203,-0.097358204,-0.041942235,-0.032788217,-0.0018772974,-0.03697761,0.079164945,0.11202754,-0.037884448,0.041745145,-0.183565,3.1415237e-33,0.048655488,-0.017369304,-0.016596103,-0.051518183,-0.0043077357,0.0068233483,0.024578044,-0.036345813,-0.049826246,-0.119221054,-0.06947665,-0.03443015,0.018320141,-0.012280572,-0.03514639,-0.053321566,-0.0016982366,-0.050598636,0.05977461,0.034010243,0.009766516,0.02496461,-0.02762159,0.02236269,0.009110385,0.054130413,0.031953886,-0.011695472,0.10052192,-0.025674328,0.016251208,-0.113002345,-0.09256555,0.031419106,0.0745364,-0.0093372455,-0.051248107,-0.009737394,-0.05294279,0.09013422,0.034541767,0.026833074,0.07374546,-0.022401646,0.05016919,-0.040233426,-0.04406381,0.062401716,0.04967174,0.05835634,0.044708926,-0.0037026636,0.08219304,-0.08397618,-0.05526408,-0.009195358,-0.013324691,0.021265535,0.029724915,0.06680336,-0.069552995,0.032048967,-0.047550537,0.03803434,-0.005093808,0.08986944,-0.121391945,-0.051094808,0.01435904,0.1293886,-0.04835364,-0.061850574,0.018715024,0.044519942,0.059524618,-0.08535327,-0.05684952,0.032047942,-0.04988206,-0.011395812,0.07622569,-0.04725432,-0.0045874333,0.03995745,-0.06210359,-0.058714177,0.0072669345,0.049778976,-0.048304193,0.015014133,0.1235949,-0.07148548,-0.016486406,0.11511711,-0.08230269,-4.36888e-33,0.07041624,-0.08309596,0.03618834,-0.04441404,-0.054311384,0.043648824,0.022640014,-0.048490215,0.05513499,0.020139685,0.054051775,-0.025166417,0.041605696,-0.002754577,-0.0009875625,0.09256374,0.006823409,0.09339204,-0.0064347284,-0.0067559457,-0.09956466,0.02642994,0.032920286,-0.02736192,-0.005866677,0.034114763,0.0056563755,0.039786022,-0.030525863,-0.005996035,-0.048207793,0.044628978,-0.11665174,-0.047753282,-0.042674094,-0.0064273872,-0.025449416,-0.082864895,0.05803155,0.009434656,-0.0014138861,0.07845373,0.037612498,0.08235953,0.025856452,0.030645626,-0.044108808,0.017777594,-0.10388084,0.01699027,0.021726841,-0.046731666,0.05205249,0.017014783,0.048155762,-0.011550226,-0.011580883,0.08577319,-0.02627858,-0.020393442,-0.0038924457,-0.08855311,-0.025956457,0.05518766,0.03169408,0.09658951,-0.0017581683,0.038742423,-0.021430302,0.053774573,0.04530408,0.07065216,0.028194515,-0.0041432697,-0.028419837,0.058673024,-0.029248446,0.012689253,0.022760304,-0.027742762,0.0366418,0.03910467,-0.04966004,-0.09152568,-0.0010157815,-0.08303264,0.035501823,0.07100734,0.02297795,0.047776118,-0.047922753,-0.014458462,-0.029257918,0.039288163,0.11658622,-3.5824254e-08,0.00881147,-0.049613126,0.010077224,-0.047285035,0.05129874,0.016042609,0.050721046,0.0005866126,0.036846105,0.016037978,-0.027370006,0.026705189,0.00726852,-0.029098976,0.06648408,0.0047126766,-0.0118063865,0.062832244,0.00041996475,0.11456753,-0.0044417707,0.01490824,-0.109800294,0.031766124,-0.030095957,0.004744046,0.086608835,-0.026322817,-0.02438941,-0.041341443,-0.027775295,0.017304357,-0.024881614,-0.1417848,-0.08150374,0.024335684,0.03727428,-0.054432448,-0.062881365,0.019388646,0.009880755,-0.0048699407,-0.060571924,-0.032425757,0.0014102217,-0.018220365,-0.01021509,-0.0035885433,0.012909507,0.0075774593,0.04332908,-0.023940444,0.008524374,-0.07037827,-0.0779181,-0.052999727,0.027083343,-0.08635909,-0.032294545,-0.04128941,-0.043754146,0.030471582,0.20487088,0.01964539 +3.6.1.17,"Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC 3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]",384,0.99999994,-0.039070573,-0.09727705,-0.017636487,-0.046509814,0.028892374,-0.033373337,0.049460843,0.01554371,0.06922665,0.053263266,0.055032216,0.014788957,-0.017647736,0.090123534,0.014360876,0.021929389,-0.060413033,0.010209356,-0.000104387414,-0.042623263,0.06257676,-0.032951623,-0.009426554,-0.006165984,0.0010946435,-0.041157234,0.058208972,0.010544423,-0.014409726,-0.09434823,-0.07857593,0.02866351,-0.007854735,-0.08374272,-0.007856252,0.09486007,-0.0702417,-0.014079152,0.017616207,-0.04337379,0.113628075,-0.09220031,-0.008806795,-0.014295045,-0.031915862,0.01264486,0.023144336,0.036049124,-0.013320063,-0.0022468402,-0.04283366,-0.07156735,-0.083894014,0.02550125,-0.020739855,-0.00019332618,-0.08675509,0.07004852,0.03904181,0.023499096,-0.012845673,-0.028787157,0.03884171,0.051479075,0.06265578,0.026021603,0.05088893,-0.059417196,-0.021683106,0.0017054607,-0.050370004,0.0050588897,0.031093605,-0.04356731,-0.033339303,-0.06023254,0.021164218,-0.0183377,0.009724607,-0.041242305,-0.09706615,-0.04689899,0.03259345,-0.024609365,0.027897025,0.027426641,-0.06302236,-0.0032518664,-0.04906509,0.004632653,0.06511592,0.024938203,0.0041523897,-0.06745829,-0.029962594,-0.0067689684,-0.00400204,0.027966106,-0.006593806,-0.026528547,0.021295847,0.07668031,-0.08624077,-0.0081061525,0.024710009,0.034395017,-0.010284377,0.01011894,-0.06622414,0.0010478989,-0.049373645,-0.01809345,0.09512125,0.045233935,-0.069784366,0.06400912,-0.05296644,-0.032142982,0.015500735,0.0029450334,-0.00643618,-0.04085939,-0.10988291,0.10494166,-0.07679466,0.10599041,-0.06823055,3.390561e-33,0.053774875,0.0683459,0.05109063,-0.023644837,-0.023102496,0.004106104,0.0005409073,-0.012767014,-0.10135429,0.0058201854,0.028554885,-0.03263851,0.10699868,-0.020235127,-0.0455012,-0.048996806,-0.04415064,0.09716418,0.052526686,-0.033871952,0.011241194,0.12684616,-0.09677842,-0.025362557,0.016921496,0.04733559,-0.08212518,0.03479944,0.009390307,-0.005444189,-0.0078086685,0.0012824209,-0.10896912,0.035378087,0.08890041,-0.01277962,-0.010175628,-0.022776086,-0.031817652,0.018994944,0.038387664,-0.032459468,-0.028116357,0.012670438,0.040592957,-0.059137516,-0.041420605,0.052282564,0.09997758,0.04872075,0.06698586,-0.025189377,0.084368356,-0.04545639,-0.037865005,-0.01642388,-0.023092993,-0.059070628,-0.017646994,0.06812633,0.028417682,-0.0016462797,-0.047339708,-0.04244928,-0.017768769,0.06553361,-0.049633544,-0.1032965,0.03204762,0.08225543,0.0037139542,0.016570505,0.10365083,0.045704134,0.027056139,0.047916453,-0.047031518,-0.062477425,-0.026668478,0.08256621,0.0058238795,-0.053849258,0.034402736,-0.06282743,-0.09442079,0.0037569779,0.04929128,-0.12079772,-0.01840011,0.005580897,0.038722742,-0.08446492,-0.08796657,0.04008223,-0.042218015,-4.072307e-33,0.09093157,-0.05590142,0.08538884,-0.046279494,-0.07592688,0.015633384,0.065561846,-0.058158547,0.052470993,0.008866379,0.11066729,-0.03302371,-0.0074559925,-0.05451708,-0.018763777,0.056781046,0.10115529,0.023178015,0.03139285,-0.0319291,-0.005310737,0.08667188,0.024224127,0.11791423,0.030437708,0.051888425,0.029834723,-0.03059681,0.028530525,0.04333284,-0.09398181,-0.027660025,-0.04468652,-0.026325606,-0.017715832,0.040145945,-0.12074313,0.025317755,0.01918871,-0.0053401855,0.019234534,0.025112275,0.116467565,0.12008036,0.0037214991,0.03605336,-0.019761253,0.09436537,-0.087853216,0.02531097,0.026645916,0.026275365,-0.013534844,0.03133105,0.048964407,0.07646489,0.00463772,-0.0347781,-0.092051595,-0.030474817,-0.0009885132,-0.04463651,0.05114078,-0.08640196,0.06000966,0.059625555,-0.011372802,-0.022838878,0.03754569,0.022740468,0.026462631,-0.022997355,0.01229561,-0.005748628,-0.067092724,-0.05929709,0.030360421,-0.015631916,-0.013003966,0.005639397,-0.044209987,0.07304879,0.018617371,-0.05692583,-0.023165148,-0.010907862,-0.0229697,0.11159266,0.07307587,0.040866442,-0.04120761,0.0063201655,0.008143584,0.007934762,0.086966634,-4.368781e-08,0.059673417,-0.0680848,0.037791245,-0.050047636,0.00065661664,0.04558806,0.02225343,-0.015032554,0.035824202,0.037222296,-0.01520826,0.050716735,0.075309776,0.0052367435,0.07481855,0.023324769,-0.057171263,0.014525316,-0.0021307475,-0.10049215,-0.061462622,-0.06417145,-0.06636846,0.03781144,0.0068246457,-0.0033855713,0.017861659,0.019033125,-0.025867416,-0.02372952,-0.009500017,-0.04896267,-0.011957124,-0.020429764,0.022950176,0.08268769,-0.02936448,-0.01534207,-0.07807171,0.078007996,-0.05592088,-0.04786587,-0.029742444,0.06296208,-0.0163322,0.013932482,0.025181543,0.040653553,0.002951319,-0.057694152,0.021269843,-0.050652064,-0.050187953,-0.07866606,-0.07468723,0.008276155,0.001448075,-0.033608355,0.037663113,0.026008843,0.052908145,0.042662647,0.10556112,-0.07044033 +3.6.1.18,The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC 3.6.1.9 nucleotide diphosphatase.,384,1.0,-0.09144132,-0.018818868,-0.03509761,-0.053840622,0.06852013,0.054485258,-0.11777124,0.03762774,0.052950095,0.031420458,0.013625577,-0.027301686,-0.10988832,-0.009399781,-0.05333997,-0.016952865,-0.079472475,-0.0020731485,-0.0012236765,-0.026265115,0.05945024,0.032672144,-0.01146119,0.008617836,0.11158963,-0.023385547,-0.015170828,-0.0112304585,0.02361925,-0.06946371,-0.040454756,0.021835329,0.010998918,-0.025086913,-0.003662575,0.077554114,0.03173497,-0.070047684,-0.0073644947,0.05476955,0.054897007,-0.023049325,-0.007265188,-0.04354896,-0.032937035,-0.0002991214,-0.00593623,0.036631618,0.032994855,0.010805389,0.0074037043,-0.08050318,-0.028493168,-0.0035351976,-0.013906715,-0.023070723,0.017647497,0.021849127,-0.023284093,0.015734332,-0.034686293,-0.023086518,-0.029533839,0.020740986,0.092983104,-0.055874113,-0.036554392,-0.043350592,-0.008244896,-0.031562485,-0.07121368,-0.060922135,0.022112671,-0.02506342,-0.06269145,0.010882194,-0.08895957,-0.049374606,0.058237873,-0.020530438,0.008664639,-0.014692507,-0.06844179,0.014295616,0.034752924,-0.0013755474,0.010276843,0.034042563,-0.03323636,-0.01391799,0.005026688,-0.041351996,-0.029309027,0.026147712,-0.12318532,0.12546524,0.06748885,-0.030538669,0.023681598,-0.06529665,-0.011974415,0.12988946,-0.008934828,-0.06559115,-0.0031737927,0.02997853,-0.048896123,0.1592946,-0.059478745,0.0042242203,-0.049656402,-0.013191531,-0.00876322,-0.0030324874,-0.031193195,0.03910319,-0.022621801,-0.08910279,-0.076131836,-0.05648371,0.012856103,-0.0057093096,0.049911723,0.09951195,0.065048575,0.05160323,-0.08102641,1.65136e-33,0.09475527,-0.041898943,-0.051251847,-0.06294505,-0.006091438,0.01727742,-0.08024979,0.07577763,-0.010797581,-0.01562239,-0.010970844,-0.04238965,0.064830914,-0.023941938,-0.0152398385,-0.034515847,-0.0006120963,-0.06861319,0.0443595,-0.03094928,0.068317235,0.034123488,-0.07927462,0.06490003,0.055962082,-0.039193206,-0.06828227,0.060663126,0.06306074,-0.0072778594,0.049288355,-0.11168421,-0.07532245,0.027455488,0.016633816,0.007210669,-0.02722077,-0.074634895,-0.015551975,0.08605337,-0.010215262,0.0022812586,0.056730144,-0.07768384,0.05594245,-0.06580791,-0.034549236,0.05774902,0.0690799,0.051525977,0.047859855,0.0014526299,0.15897979,0.0065825065,0.02395972,0.021173285,-0.038856544,0.017631352,-0.027688382,0.08929104,0.025480185,0.068069115,-0.039211858,0.07415312,-0.04186172,0.027857775,-0.078815795,-0.019423177,0.06951558,0.121822216,-0.04921178,-0.020071115,0.04118087,0.010876748,0.02718746,-0.063634016,0.042490024,0.025800321,-0.038711317,0.031643927,0.005107023,0.0011403973,-0.015327005,-0.0016054173,-0.010922083,0.060786016,0.02544214,-0.026926504,-0.017528672,0.039659362,0.10957504,-0.03998918,0.020310631,-0.049896725,0.04807442,-2.5619124e-33,0.08106508,-0.058621157,0.04592718,-0.09625753,-0.03688949,0.08241534,0.057776704,-0.028012946,-0.01866661,-0.08729307,0.007061236,0.057032004,-0.027743433,-0.015109474,0.018295273,-0.014027023,-0.033493046,0.021233207,0.033449125,0.024785584,-0.07643351,0.1249116,0.07879545,-0.001858914,0.076729074,-0.06799508,-0.04811084,0.044213336,0.004261011,0.031841185,-0.02401232,0.02371742,-0.07182201,0.00022867811,-0.025483614,-0.010238359,-0.06144726,-0.005238159,0.007333408,0.04094875,-0.004124033,-0.0053399084,-0.021545222,0.00975221,0.08375718,0.05436446,-0.11170223,-0.008892758,-0.004355896,-0.028425764,0.0053069433,0.01374177,-0.009733322,0.06462723,0.07828062,-0.03935821,0.0036365334,0.027785318,0.0614154,-0.01952203,0.0497936,-0.08333984,-0.028739072,0.0069012297,0.05183175,0.04701845,-0.029693449,0.05791709,0.02288967,0.065814726,0.07497759,0.023301499,0.019219413,0.054345854,0.035262264,-0.03010422,-0.048012417,0.0382168,-0.06207541,-0.031771515,0.024590112,0.07258319,-0.08649824,-0.061627675,-0.059117287,-0.0063252305,-0.02364396,0.092675455,0.008502276,0.023201024,-0.049700152,0.0016994488,-0.020796493,0.04176131,0.06969502,-3.0725065e-08,0.0225753,-0.059703223,0.07923118,-0.0550021,0.03872103,0.04185115,0.011429438,-0.0153939705,0.008112834,0.028731754,-0.036380943,0.114716075,0.024958394,0.007329536,0.06026406,-0.06818179,0.0004162471,0.032576505,-0.03773791,0.026644431,-0.073347546,0.031584475,-0.11627295,0.10111349,-0.010605812,0.013074987,0.034642067,-0.025820514,0.018196475,-0.03385272,0.03997287,0.022565698,0.073306166,-0.06109683,-0.047881946,0.03984709,0.0055439314,0.016266368,-0.056073878,0.056156486,0.019381853,-0.1033794,-0.039944325,-0.007569117,0.024770025,0.005826631,0.056337617,-0.044835888,0.001012299,-0.02107122,0.020955777,-0.0351814,0.0018974782,-0.098810256,-0.065088406,-0.037749413,-0.019481257,-0.094649896,-0.05628888,-0.03330859,0.048672993,0.030910736,0.15700822,-0.018377684 +3.6.1.19,May be identical with EC 3.6.1.9 nucleotide diphosphatase.,384,0.99999994,-0.10233107,-0.056471832,-0.03643608,-0.09152445,0.04792731,-0.05648549,-0.04851404,0.038437687,0.017903743,-0.05874791,0.030795077,-0.038443327,-0.09512935,-0.02456867,-0.037950255,-0.01625972,-0.086688824,-0.080631144,0.02503749,0.018100502,-0.010637229,0.06398592,0.015151972,0.015402241,0.02833035,0.038575176,0.06307682,0.083343975,-0.0012303841,-0.09025182,-0.02383059,0.014938954,0.01670161,-0.039381977,0.051565643,0.03626426,-0.022384996,-0.05156493,-0.033319704,0.07194007,0.09698394,0.010190713,0.02412273,-0.021975592,-0.030572522,0.032420035,-0.048406806,0.06457842,0.074485175,0.033337038,-0.0025323713,-0.09004323,-0.008307759,0.025341982,0.036867343,0.008998303,-0.10269462,-0.016224677,-0.021234158,0.045650788,-0.06336748,0.010347372,0.05319228,-0.02582382,0.1361144,0.0007485239,0.058306668,-0.122060336,0.0002503311,0.024419134,-0.04820931,-0.052767012,0.01449353,0.065132976,-0.0518906,0.089006014,0.04346394,-0.05749241,0.013225359,-0.017780358,-0.081635155,-0.025012767,-0.10071054,0.0014446994,-0.014957099,-0.042314272,0.017055616,0.010139326,-0.053690568,0.020203248,0.006594642,-0.03223597,0.0121775,-0.061898816,-0.0867756,0.08851019,-0.033158153,0.119080685,0.04138242,-0.029425824,0.019592008,0.11416907,-0.053407382,-0.027006892,0.004187193,0.00122678,0.036010046,0.08326862,-0.04553901,-0.03398454,0.0047141514,-0.024172775,0.022370126,0.010043894,-0.07783889,0.053089168,-0.040480502,-0.038951453,-0.010996552,0.054847404,0.062158782,-0.025040658,0.03284518,0.036797464,-0.005849127,0.027071219,-0.07988318,1.0764688e-34,0.027521057,0.009278694,0.0690754,-0.021172617,-0.049737427,0.020390732,-0.07395119,0.052428927,-0.087406054,-0.006144221,-0.026210934,-0.068926714,0.108612075,-0.006229695,-0.059278604,-0.03775059,-0.039802797,0.053842817,-0.048559863,-0.029154614,0.08004908,0.024436422,-0.018682351,-0.025680497,0.049992125,0.007199478,-0.08379318,0.022058764,0.093806885,0.0013233676,0.008729972,-0.039674602,-0.063645445,-0.02064397,0.01756912,-0.011396612,0.038626783,-0.089099824,-0.006377706,0.06176941,0.025829276,0.029375287,0.026206808,-0.05505496,0.069164045,-0.06368583,-0.037658494,0.038342476,0.09550216,-0.029569479,-0.015838422,-0.057122566,0.17436777,-0.041606344,0.08757135,-0.038399197,-0.058309205,0.04320923,0.004905167,0.0676224,0.061806697,0.0905394,-0.10067383,0.055314977,0.021736495,0.05987778,-0.054260667,-0.0029782197,0.001911759,0.06913281,0.035820827,-0.06727284,-0.016592562,0.04854714,-0.015185601,-0.047196034,-0.07927319,0.02697429,-0.04256445,0.040499765,-0.019958032,-0.023389926,-0.0018771527,-0.02989659,-0.10946069,0.055585112,0.05577502,0.0020300443,0.0004963257,0.03774514,0.10676757,-0.0076917643,-0.06258124,-0.037036646,-0.024172936,-9.435956e-34,-0.0020415222,-0.068504795,0.007028068,-0.0787007,-0.03815171,0.041582834,0.09859353,0.03412134,-0.011402239,-0.018190803,0.09397458,-0.017001092,-0.013209723,-0.12668273,0.0112103075,0.026655696,-0.062393304,0.009426111,0.04452285,0.03214271,-0.02202759,0.07139271,0.024182009,0.052717723,0.0041263863,0.015116416,-0.0012527977,0.048844077,-0.00403615,-0.01930318,-0.12707467,0.05809288,-0.052513424,-0.0055594626,-0.0019237171,0.009322735,-0.017117487,-0.07149316,0.05094012,-0.025859417,-0.052707125,0.072078556,0.055587884,0.03994501,0.05602332,0.07156611,0.021845296,0.04990114,-0.01028099,0.008087294,-0.042107947,-0.023544751,0.0021366451,0.06933182,0.0047478103,-0.041490175,-0.03341131,0.0019202785,0.043114495,-0.015266766,0.043332323,-0.05724296,-0.02943682,-0.01254328,0.07456583,0.065775596,-0.015188918,0.03727211,0.011662159,0.003621607,0.024581145,-0.06563245,0.02043152,-0.051964276,-0.006835165,-0.039497115,-0.014779701,0.09110193,0.03877194,-0.049252942,0.028685953,0.029960716,-0.03200576,0.02853168,0.028268375,0.052903954,0.0056482386,0.06392478,-0.045273416,0.018964054,-0.0858897,-0.020934919,-0.09139514,0.056856386,0.023067473,-2.3328322e-08,0.17387004,-0.072711706,0.054909933,-0.012750312,0.056681823,-0.010119074,-0.024909558,0.028555308,0.02615012,0.08926434,-0.004535433,0.016103968,0.07631362,-0.059010495,0.050561167,-0.059448738,-0.051590096,0.028775029,-0.021384085,0.026297307,-0.010194676,0.020082183,-0.039685193,0.014282502,-0.020557228,0.07484219,0.016718838,0.029617954,-0.021298023,-0.08478199,0.010111104,-0.00038274133,0.018793602,-0.04395586,-0.019269262,0.04966409,-0.038473137,0.038955126,-0.035571523,0.034781747,-0.023258325,-0.051780976,-0.082181,-0.007803201,-0.0059548444,0.00499635,0.030076228,0.035994805,-0.013925827,-0.08535711,-0.03744649,-0.04060143,0.045677144,-0.024713518,-0.06417812,-0.07498127,-0.06197114,-0.051368445,0.0033829259,0.026575226,0.08311057,0.0037781908,0.10355102,0.012989102 +3.6.1.20,Also acts on inosine and uridine compounds.,384,1.0,-0.043158226,-0.07719115,-0.059609838,0.060195148,0.018721651,-0.007580101,0.013047278,0.05313467,0.09327127,0.025550803,0.04994135,0.041360967,-0.066636465,0.12070117,-0.022013973,0.063233145,-0.055579595,0.093973234,0.021970274,-0.045590587,0.098586656,0.003426705,-0.018650666,-0.0071145105,-0.029322887,0.00810894,0.020976659,0.015650615,0.0050439746,-0.08164479,-0.06652047,0.053193625,-0.022800615,-0.041323867,-0.005036362,0.092720576,-0.07999244,0.017079853,0.049883164,-0.022596955,0.051967546,-0.12351327,0.015318362,-0.01649685,0.009956863,-0.028849311,-0.028095026,0.055384364,0.048387114,0.032096926,-0.057175092,0.030106258,0.033213448,0.0538006,-0.03983206,-0.0018014548,-0.14248554,0.011525568,-0.0033960345,-0.025757393,-0.020293685,0.0091206925,-0.019755615,0.028755132,-0.008658679,-0.013387541,0.003488987,0.023315752,-0.013972356,-0.06276653,0.023198538,-0.042006206,0.023122998,0.034378484,0.053855002,0.0033140683,-0.046913262,-0.03542075,-0.0077298963,-0.0045601437,0.04953314,0.023301609,0.038079977,0.003855376,0.09253204,0.024749234,0.0055280514,-0.005996836,-0.053611767,0.010143809,0.048398964,0.0015634577,-0.007996929,0.00275889,0.013308577,-0.0128341485,0.021072596,0.026710272,-0.034340806,0.0046386276,-0.005045458,0.008484167,-0.12273659,-0.045953467,-0.014210777,-0.015064478,0.07958498,0.017299816,-0.0040664645,0.016493442,-0.026121492,-0.04962623,0.04211721,0.006025137,-0.033857618,0.05307729,0.044135507,0.035928514,-0.030009747,-0.020160502,-0.023062402,-0.05561171,-0.03159466,0.026809838,-0.08925166,0.051444124,0.037779804,-5.7054377e-34,0.06771566,-0.0077661276,-0.004151256,0.032776393,0.005718244,0.023787063,0.00071923604,-0.053703953,0.011754116,-0.09389232,-0.08755861,-0.03990743,0.032053564,0.0015249,-0.05817528,-0.012579666,-0.04637574,0.022651471,0.124981314,-0.04027827,0.008391719,0.12972988,-0.069708355,0.010686952,-0.020015698,0.014902501,-0.057709735,-0.023813393,-0.06528884,-0.029652953,0.07594394,0.051665198,-0.083983056,0.059490148,0.011826014,0.08016103,-0.0874862,-0.012760357,-0.06005406,0.03280862,-0.049069673,0.029028457,-0.06434515,-0.020163381,-0.013389155,-0.064463064,-0.046311434,0.053663917,0.012196964,0.057210777,0.0431367,0.0072643757,0.043837037,-0.043768283,-0.039274078,0.00648919,0.022672256,-0.081567235,0.0034794358,0.07465782,-0.007625347,0.035732806,-0.01624035,-0.010430475,-0.044390257,0.015610409,-0.08151483,-0.029887328,-0.019999772,0.03670109,-0.06767156,-0.02371213,0.06948773,-0.03200718,-0.012520848,0.015559948,-0.07971459,-0.039573923,0.028662689,0.022106133,0.020573635,-0.13312003,0.09249025,0.0530411,-0.044262167,0.024862198,0.011827302,-0.07667536,0.006558158,-0.0500508,0.07212942,-0.0403683,-0.073658615,-0.025494128,0.1089787,-2.0676193e-33,0.08558915,-0.06900906,0.049617976,0.013160833,-0.019690897,0.035805363,-0.01567024,-0.0674749,0.036763392,0.038253326,0.074304916,-0.050204527,-0.03302617,-0.05141462,-0.026722658,-0.0133521175,0.028154142,0.04535022,-0.010331395,0.017540462,-0.0987915,0.083271,0.019034801,0.082386166,0.015080724,0.037662026,0.01915778,-0.105162926,0.021219926,0.022016069,0.003114457,-0.02659513,-0.121719174,-0.058797672,0.042762082,0.03628174,0.0032706747,-0.031954303,-0.040815767,-0.094868444,0.048487123,-0.041084494,0.08356214,0.10796495,0.060949925,0.011264598,-0.020559032,-0.009140563,-0.14471325,-0.047086805,0.0082875965,0.037142027,-0.0060247104,0.019789897,0.07037542,0.046493698,-0.0013812706,-0.06267172,-0.02287779,-0.007201557,-0.059228998,0.005147708,-0.05411899,-0.08291372,0.025077002,-0.023577709,-0.09540835,0.058476336,0.10576998,-0.04386357,0.06917389,-0.069643125,0.013344797,0.023635957,-0.06333696,-0.09866161,0.00068686344,-0.090499304,0.038325537,-0.02535569,-0.09250716,-0.02053195,-0.030922648,-0.023831066,-0.06233766,-0.027481662,0.034228534,0.027264273,-0.019671414,0.085482635,-0.0043582995,0.037777647,-0.016304001,0.045658875,0.0029023034,-1.8923128e-08,0.0473101,-0.04323526,0.07808561,-0.034432206,-0.049227558,-0.029515546,0.104208596,0.12657893,0.012915812,0.024047757,-0.01158745,0.07944856,0.12612517,-0.0034393794,0.11551001,0.04811325,0.0034485608,0.012691006,-0.040346146,-0.028989963,-0.08570378,-0.06760561,-0.040245324,0.043052796,-0.0014179928,-0.06957604,0.053055212,0.05360459,0.019016135,-0.015660554,0.03345455,-0.057168037,0.023043998,-0.021479849,0.015155037,0.08826918,0.08142703,-0.07648467,-0.029464431,-0.050568134,-0.05750641,-0.04813355,-0.021677904,0.033273753,0.03507726,0.009785837,-0.00240868,0.020528844,-0.013935659,0.0018874159,0.012983852,-0.005129394,0.023493037,-0.011632969,-0.03522155,0.044466227,0.028664798,-0.045231175,0.120935,-0.0045228177,0.021839885,0.03188611,0.14464998,0.007030492 +3.6.1.21,Has a specificity that is distinct from that of UDP-sugar diphosphatase (EC 3.6.1.45).,384,1.0,-0.07888591,-0.080011316,-0.04944074,-0.07436151,0.048044764,-0.010157134,0.031014377,0.07244084,-0.031669304,-0.03467673,0.0751823,-0.0066928677,-0.04375431,-0.0022037327,-0.06473665,-0.009483806,-0.006700503,-0.10211509,0.011787405,0.03973886,0.07352724,0.010781024,0.037721887,0.018036796,0.08579576,0.012276572,0.06959745,0.036391318,0.001403899,-0.091554664,-0.050663702,0.0290893,0.0021423316,-0.048887253,0.062568404,0.05834011,-0.02743798,-0.027720561,-0.0154775,0.02698283,0.113853425,-0.04517126,-0.008801242,0.026550855,-0.029271487,0.014306465,-0.06772013,0.06954669,0.0056281933,-0.0052946955,-0.07420199,-0.072295934,0.0061588604,0.07405351,0.047141396,-0.042957194,-0.08971989,-0.009860595,-0.019028233,0.010124935,-0.06342076,-0.016479334,0.029234763,-0.021402158,0.13351153,0.010090322,-0.006998464,-0.067410864,0.0025207275,0.024442092,-0.05739242,-0.032428198,-0.060993727,0.073917046,-0.030329244,0.06973591,0.035940297,-0.04674938,0.030581603,-0.053311665,-0.059056673,0.007953394,-0.03514263,0.056867663,-0.007908933,-0.049372427,0.027077997,0.030885011,-0.05442797,-0.0043625003,-0.032837022,0.011679377,-0.037375674,0.01883934,-0.13302602,0.0387651,-0.0015652744,0.04249304,0.05912646,-0.03332491,-0.049808346,0.035161056,-0.06140504,-0.09016322,-0.069226705,-0.04637567,-0.0040515577,-0.009848995,-0.012397559,0.02335084,0.00041241155,0.010537055,0.048598755,0.008690095,-0.06793884,0.033023335,-0.02702686,-0.040325843,-0.03258322,-0.015209406,-0.023186697,-0.045469992,0.04048247,0.05931064,0.01405832,0.01661338,-0.080954514,-2.191468e-33,0.06289319,-0.05126325,0.03983659,-0.034227215,0.012407387,0.03756205,-0.072995,0.016215226,-0.029024528,0.042486683,-0.058690026,-0.04374965,0.05462196,0.044019308,-0.049625352,-0.013006336,0.003886571,0.03970288,-0.0033233264,-0.012607834,0.0009745354,0.09470807,-0.036668703,-0.03679485,0.022286098,0.03410089,-0.11232385,0.03579328,0.100109436,0.032739192,0.06776389,-0.030185198,-0.10372275,-0.0050069895,0.04722957,0.021486603,-0.035579585,-0.1023911,-0.047128383,0.04753511,0.024238054,0.02474496,0.03874698,-0.054841246,0.014670448,-0.04497118,-0.073180206,0.004544924,0.023444572,-0.014481802,0.02171494,-0.014717991,0.1133716,-0.022253491,0.0638789,0.031328972,-0.06640999,0.030828819,0.012110789,0.11786029,-0.013269391,0.110714726,-0.08898531,-0.035851307,-0.008680363,0.09063831,-0.057626527,-0.03296204,0.03213423,0.026348375,0.0439724,-0.021549836,-0.0031209642,0.07429255,-0.047343403,-0.048610475,0.00080945744,0.009090853,0.036751434,0.03532956,-0.06329187,-0.04935247,-0.04439213,-0.045173634,-0.122378424,0.05628062,0.01166458,-0.03199292,0.0012130674,0.044555847,-0.0071307076,-0.012034605,-0.063338794,-0.03491447,-0.047371384,-2.4794181e-34,0.021240527,-0.10726683,-0.022549951,-0.020873783,0.02483391,0.017333902,0.11502557,0.027065959,0.027738309,-0.031044098,0.09482434,-0.023125948,-0.0015298526,-0.065869235,0.014449702,0.07436952,-0.066887505,0.027662104,-0.0218897,0.0028503693,-0.0686559,0.15061338,0.048367005,0.091331534,0.02509732,0.037393074,-0.05199642,0.10363787,-0.005573248,-0.021485165,-0.0259263,0.047975633,-0.095811225,-0.08511301,-0.052323822,-0.00028674086,0.00014075823,-0.06220827,0.008520317,0.03225606,-0.0282647,0.045802187,0.031740524,0.044177145,0.08377137,0.06434228,-0.0068085664,0.02384419,-0.026677763,-0.009835776,0.013594197,-0.002474885,0.049984753,0.091450535,0.0059541054,0.03339453,0.004256904,0.016195726,0.024216421,-0.03671781,0.0588831,-0.10239199,-0.043230426,-0.0017434424,0.08881399,0.11943424,0.008176499,-0.05366559,0.054095916,0.003238361,0.058721032,-0.07913242,0.0327371,0.007977489,-0.040058456,-0.003757326,-0.07138592,0.043175012,0.029739782,-0.046794947,-0.010387722,0.049915947,-0.0031767075,0.024493832,0.03306042,0.0037245422,-0.00827558,0.018008549,-0.008342834,0.026581535,-0.06327756,-0.03173047,-0.082515,0.07940221,0.07248086,-3.0520795e-08,0.15468967,-0.049012832,0.0467906,-0.02626336,0.047106396,-0.04240587,-0.000456848,0.032560688,0.051632762,0.056065314,-0.008035103,0.1207941,0.016885951,-0.023263872,0.050328985,-0.05362635,0.0005218716,0.021486461,-0.077744134,-0.038133703,-0.030170765,0.0017482747,-0.1086239,0.023802055,-0.05728484,-0.0028051762,0.05445237,-0.014377508,0.0068000164,-0.072772704,0.03661406,0.0362278,0.07312619,-0.05863282,-0.015234412,0.087172195,-0.027923295,-0.01865248,-0.008275254,0.052282777,-0.052400324,-0.07460509,-0.06442117,-0.0022418874,-0.027042732,0.024186872,0.021566547,0.07208846,-0.04489492,0.006204272,-0.02190746,-8.762109e-05,-0.017748391,-0.04812024,-0.0645413,-0.05106141,-0.057188936,-0.033734784,0.0010796095,-0.04311086,0.056404088,0.0063844803,0.14718643,-0.02592046 +3.6.1.22,"This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. Also acts on other dinucleotides, including NADP(H), FAD(H2), and the thionicotinamide analogues of NAD+ and NADP+.",384,1.0,-0.05430195,-0.044581175,-0.05812547,-0.029154906,0.05217615,0.05483444,-0.06508966,0.03693019,0.034708526,0.046380527,-0.018762153,0.028091196,-0.10946224,0.06370266,-0.015657123,0.05328714,-0.04525499,0.036312103,0.05893952,-0.020697752,0.064448446,0.03625369,-0.02498849,-0.033400223,0.030887546,0.0025241855,0.018612653,0.00038710615,-0.029571079,-0.07920887,-0.041310795,0.02220988,0.012727474,-0.047183424,-0.03067347,0.07900121,-0.03716471,-0.038941782,0.0010428616,-0.004154274,0.02334273,-0.015693156,-0.0983054,0.020699795,-0.05667391,-0.016768333,0.031077098,0.066314004,-0.018758623,0.009525644,-0.059827954,0.013146276,0.0012215176,-0.018975317,-0.028823117,0.020116394,-0.0021521526,-0.010492237,0.0058722002,-0.055140838,0.0109034395,-0.048856962,0.031449888,0.041973516,0.07367974,-0.042226903,0.012007409,-0.0377863,-0.04074662,-0.07023007,-0.05662803,-0.04992449,0.01664593,-0.002358405,0.0025022437,-0.037528217,-0.064261645,-0.055654872,0.083744645,-0.002038402,0.017935777,0.05678231,0.02321692,0.059498314,0.035206076,0.00085818203,0.005134668,0.007561032,-0.015379013,-0.014020458,0.0042995713,0.008649509,-0.020203363,-0.020286253,-0.15027486,0.02186479,0.055745315,0.010897559,0.017149562,-0.04504516,0.023936097,0.09523757,-0.08452263,-0.09635611,-0.033148583,0.033827662,-0.057420965,0.075142585,-0.02719781,0.01826502,-0.06525726,0.044315495,-0.022991296,-0.01367209,-0.02763539,0.079962134,0.0075247553,-0.08322294,-0.09659646,-0.038523488,0.0017209039,-0.054571763,0.040057685,0.07597509,0.011398922,0.02005977,-0.08880983,4.8953246e-34,0.081724085,-0.018642496,-0.060591303,-0.08534604,0.08981611,-0.04319474,-0.05288858,0.03772167,-0.027240554,-0.00474286,-0.03204288,-0.070574656,0.04414787,0.03059363,0.025714563,0.044279628,-0.02672357,-0.028581548,0.046240684,-0.027337862,0.028209293,0.122778036,-0.024241958,0.038317718,0.021082545,0.029257866,-0.052902047,0.11263277,0.020806946,-0.02418797,0.087575845,-0.11540133,-0.106468044,0.0019177793,0.0650395,0.0010441225,-0.07629686,-0.015669307,-0.055892576,0.060509358,-0.035642177,0.068042696,0.020305505,-0.054111958,0.103647225,-0.07258764,-0.030377718,0.08674513,0.017848684,0.0624598,0.0632679,-0.08342228,0.1393507,-0.06299214,-0.01200759,0.045170188,-0.06271597,-0.032127343,-0.006372488,0.03588275,0.0148565825,-0.041163456,-0.027541354,0.0795147,-0.03775359,0.02432271,-0.041674245,-0.07450528,-0.006668166,0.11081117,-0.0019175622,0.03533953,0.022224177,-0.01156197,0.040813275,-0.05628442,-0.0086902995,-0.002904739,0.025871117,0.046838727,0.0004643207,-0.04647068,-0.0029048347,-0.043379463,0.0023226594,-0.012763012,0.0022179405,-0.03756712,0.012313018,0.02392096,0.07379124,-0.089956135,-0.029956516,-0.047455065,0.1074036,-2.8808909e-33,0.05133867,-0.03271047,0.060572397,-0.056163426,-0.09038888,0.09290544,-0.002103034,-0.043867994,-0.011451474,-0.045033917,0.012678667,0.028826404,0.014678983,-0.029373365,0.013900682,-0.015387193,-0.009175773,0.05365328,-0.059903476,-0.0022462576,-0.07979947,0.09110631,0.024484456,-0.03673543,0.081048444,-0.029454375,-0.056051895,0.07430303,0.08064443,0.019473642,-0.028198035,0.03985751,-0.035911832,-0.019311272,0.029095186,0.03824749,-0.059552852,0.031246739,-0.004059128,0.028071184,0.02047879,-0.0019376314,-0.010889093,0.07042043,0.020253664,0.043126475,-0.14184485,-0.032242954,-0.010347555,-0.079936974,0.0363236,0.044879105,-0.009579663,0.018765425,0.117679566,0.049948353,0.012754254,-0.0064944187,0.053206056,-0.017593563,-0.012930778,-0.070298545,0.00034204256,0.0022213063,0.060003296,0.017708136,-0.06601269,0.061799675,0.03843684,0.009804449,0.05987426,0.03644529,0.014051754,0.036820274,-0.016822742,-0.037177455,-0.040331848,0.024890365,-0.038168058,0.036326155,0.05259286,0.014611074,-0.05862252,-0.06840355,-0.070953585,-0.03156801,-0.006456069,0.07796603,-0.020601347,0.06982643,-0.0036372365,0.0784954,0.009171256,0.010048081,0.01793493,-4.1298854e-08,0.015058532,-0.03318242,0.097286634,-0.07826743,0.00072489865,0.033249598,0.005569627,-0.0028417367,0.0302051,0.01242898,-0.06984281,0.17257157,0.048839137,-0.025495585,0.10058244,-0.05253284,0.006076379,-0.034107417,-0.055305324,0.0040217587,-0.09114627,0.013401805,-0.12416041,0.096870095,0.030162789,-0.0670978,0.039026313,-0.056294393,0.042905655,-0.02327938,-0.0027865854,0.051536795,0.047881465,-0.05276075,-0.07157096,0.029969158,0.0139467595,-0.03933859,-0.06168256,0.043783605,0.00838726,-0.068280816,-0.085769445,0.008499814,0.0025069222,0.019719403,0.021576144,-0.06455033,-0.0552755,0.010629414,0.009681059,-0.019873936,0.007358985,-0.085366644,-0.09536229,0.045560103,0.022376107,-0.08562285,-0.027690703,-0.026766984,0.0289435,0.0048819412,0.14499111,-0.020963462 +3.6.1.23,"The enzyme catalyses the Mg2+-dependent hydrolysis of dUTP to dUMP, providing the substrate for EC 2.1.1.45, thymidylate synthase, leading to production of thymidine nucleotides. By reducing the effective ratio of dUTP to TTP, the enzyme also reduces the possibility of dUTP incorporation into DNA.",384,0.99999994,-0.13246486,-0.005708013,0.05994627,-0.055582527,0.053203296,-0.025308318,-0.059425697,0.049773064,-0.035770178,-0.006000269,0.03656917,-0.002610515,-0.017835831,-0.016035138,0.0058249217,0.00084503205,-0.06031391,0.07153445,0.009962768,-0.091162056,0.018116299,0.0036962114,-0.026713476,-0.008474335,0.010493439,0.07105276,0.055142246,-0.012513285,0.01635479,-0.06679451,-0.02357261,-0.04727198,-0.020810455,-0.11788201,0.020828772,0.10005951,-0.018934371,-0.021568703,0.0062238486,-0.015640747,0.06314551,-0.02191582,0.016056525,-0.018194076,-0.04313903,-0.07068819,0.028240662,0.058372498,-0.016580045,-0.015653534,0.046313178,0.0294851,0.0095287245,-0.026559636,-0.012941194,0.03146871,-0.123763256,0.00077363243,-0.04411448,0.04650969,-0.011278353,0.041930918,-0.018302443,-0.03796828,0.13784343,-0.024419528,0.09503741,-0.021036651,0.031051394,-0.027999546,-0.039995305,-0.048266694,-0.08050458,0.031266626,-0.018102478,-0.00552692,0.004367635,-0.07286003,0.0019080166,0.048853762,0.00025977506,-0.01646344,-0.0033716657,0.013153914,0.0038395722,-0.030175162,0.051280998,0.037756145,-0.015064344,0.008980691,0.07847311,0.012218793,0.0047233864,0.022254853,-0.019501032,0.08768797,-0.06762688,0.10742243,0.028617965,-0.0071422695,0.010991989,0.09231562,-0.061888266,-0.01599784,-0.021909429,-0.057739932,0.025182625,0.026286444,0.06114315,0.01847177,0.048243567,0.04628122,0.008400042,0.068315275,-0.041413613,0.033919513,-0.052100837,-0.047442917,-0.0035760868,0.020751953,0.046324313,-0.042726953,-0.021814957,0.122598045,-0.032354876,0.009639465,-0.018751714,8.921793e-34,-0.034627117,0.03700151,0.057086732,-0.023273025,-0.038451534,0.019484809,-0.030087102,0.046509538,-0.06376433,-0.027302854,-0.097545594,-0.07708678,-0.008264188,0.043413192,-0.13138318,-0.15533297,0.013504593,0.11830591,0.07799795,0.021124916,0.013777122,0.14103444,0.039139155,0.017538542,0.046383403,0.044223875,-0.038494755,-0.021155296,0.11324026,0.020011049,-0.013614231,-0.09224062,-0.0679164,0.05458475,0.03515222,0.020979991,-0.04885013,-0.04754345,-0.0014464797,0.08514027,-0.054977622,0.042908907,-0.04348932,-0.02552294,0.014155143,-0.09803683,0.008272106,-0.036592297,-0.020716406,-0.0029507477,-0.016585166,-0.01304239,0.013406407,-0.0406878,0.017198252,-0.039516896,-0.041781925,-0.074416846,0.06524761,0.09967986,-0.009945607,0.11127435,-0.06502124,-0.021272399,0.016265934,-0.041882914,-0.056659058,-0.07004931,0.07112644,0.06318186,0.01478387,-0.011453637,0.053841878,-0.01134704,0.027906634,-0.0056351097,-0.06371234,0.095492564,0.06762302,-0.010735834,-0.027873512,-0.03939042,-0.007473689,-0.035321012,-0.012680626,0.027377589,-0.05267587,-0.02654291,0.021391029,0.030562023,0.08056236,0.0053410116,-0.022364877,-0.07261221,0.025509976,-1.6425282e-33,0.09412194,-0.06556906,0.0034329928,-0.062730394,-0.08613042,-0.026322354,0.012680848,-0.04076565,-0.0032719953,-0.0005569112,0.04541781,-0.016118119,0.03735711,-0.12365348,-0.010950033,-0.049019624,0.06557547,0.048871312,-0.07802139,-0.029596707,0.009647275,0.0708634,0.074147254,0.09293361,0.038312055,-0.043426055,0.00477562,0.05207164,0.115820795,0.018695286,-0.03333321,0.029120868,-0.03943764,0.026259774,-0.0023275486,0.04131853,-0.017683508,0.10378606,0.055628076,-0.0021467325,0.02065794,0.0160922,-0.041023247,0.034159046,0.0047504026,0.03285234,-0.029385785,0.05500666,0.049827125,-0.08187818,0.07239596,-0.013763899,-0.040495217,-0.0336005,0.03502084,0.0021566155,-0.0034492156,-0.009524669,0.0003446952,-0.005070934,0.028291548,-0.054463923,0.011304323,-0.05857565,0.023109129,-0.003919374,-0.07133559,0.06322198,0.005522489,0.083584525,-0.001889546,0.0027070567,0.082035616,-0.06256315,-0.019960567,0.047449563,-0.10364977,-0.067312025,0.082391195,-0.071475215,-0.03774267,-0.0033858933,-0.03365408,-0.08374497,0.04158236,-0.10013625,0.011923385,0.08381109,0.017058227,0.020208312,-0.089489296,-0.050386645,-0.0789055,0.10689707,-0.004494808,-3.356233e-08,0.03668491,-0.112703,-0.0016042015,0.055732056,-0.0027745445,0.046653617,-0.007544598,-0.034845807,0.117555305,0.010199723,-0.0034100884,0.003871274,-0.0116285505,-0.023083828,0.050361075,0.0039378814,-0.0071409857,0.04453457,-0.024139507,-0.042814974,-0.019407984,0.0075564925,-0.107100256,0.02738143,0.031728067,-0.017893834,0.03318262,0.05541132,0.0073282984,-0.06516161,0.04369623,-0.054087784,-0.032719027,-0.0012617889,-0.0003170172,0.009702307,0.005372686,0.0011211591,-0.036687445,-0.007212291,-0.033018697,0.0035998628,-0.018105136,0.020256568,0.019220777,0.0016842561,0.0163433,0.056971367,-0.09649829,-0.012632854,0.059459202,-0.050305557,0.01664392,-0.029001908,0.026239948,0.017403185,0.010236487,-0.06361492,-0.020892028,-0.0038034327,-0.018940292,0.074468285,0.1981689,-0.044711575 +3.6.1.24,"Attacks ribonucleoside 5'-nitrophenylphosphates, but is inactive against phosphodiesters.",384,1.0,0.00012842682,-0.04804411,0.048763815,-0.04194223,0.01711994,0.014885506,0.03093689,0.04900437,0.03514227,0.086642385,-0.03349457,0.06769115,-0.019903371,0.1393592,-0.03839384,0.038797192,-0.018317904,0.03995688,0.06199351,-0.010946867,0.010561604,0.054870456,-0.0124096405,-0.020898705,-0.0027650332,-0.012636558,0.0024338327,-0.012876058,-0.028595047,-0.0167183,-0.044236604,-0.02602068,-0.026118396,-0.011691167,-0.009261526,0.04946918,-0.029311232,0.0017799817,-0.026992306,0.037054747,0.047527708,-0.051156834,0.022144683,-0.023759335,-0.075331874,0.038911514,-0.06752518,0.12949987,0.09547555,0.02655033,-0.02180447,-0.07968013,0.054616056,-0.060963918,0.045170557,0.00089820457,-0.07556009,-0.027959606,0.04489033,0.011967247,0.007452274,-0.040079925,0.020554917,0.046772037,0.06228953,0.049018435,0.02537933,0.0086395675,0.044118322,0.034020085,0.020781169,-0.021494089,-0.0015108311,0.0021803374,0.021305596,0.090744026,-0.02257512,-0.05255689,0.055819876,-0.08449586,-0.0041518286,0.0074865506,0.05276655,-0.005525175,0.021449452,0.039472714,-0.035961602,0.023763858,-0.0297208,0.0030184404,0.017854977,-0.012133547,0.05182718,-0.034209788,0.030273395,-0.034908544,-0.10218279,0.021205658,-0.13628569,0.015271056,0.044527087,0.027174272,-0.042595595,-0.04540286,-0.01639904,0.076218076,-0.012353348,-0.1099178,-0.018904366,0.020353312,0.052242003,0.023349633,-0.057910185,-0.079770215,-0.01313005,0.02124358,0.009928452,-0.04326769,-0.0133079,0.014047077,0.027817646,-0.083556734,-0.03303876,0.008219754,-0.105202,0.11092092,-0.086220704,3.3632058e-33,0.030822275,0.029522732,0.022327734,0.021186454,0.014579976,0.018138353,-0.039971743,-0.043934904,0.06254883,-0.04055022,-0.0663432,-0.09819117,0.10349309,-0.03825728,0.041084733,0.066223696,-0.060157005,0.07121017,0.027686095,-0.010691437,0.009537549,0.039436568,-0.022961529,0.08249833,-0.0010407737,0.016168194,-0.13442858,-0.0034434241,0.036963835,-0.039203655,0.034447484,-0.030043148,-0.018646386,0.04547863,-0.036400322,-0.02266718,-0.012070291,-0.035942044,0.0032484233,-0.01679322,0.00046922715,-0.0448069,-0.046212845,0.024650054,0.10117432,-0.061311007,-0.08936246,-0.042437185,-0.0669342,-0.0011132547,0.04553041,-0.045318846,-0.0039244536,-0.021944776,0.01950199,-0.030963222,-0.014343084,-0.030518113,0.06074833,0.00979701,0.05762453,0.048594613,0.048510566,-0.030575573,-0.04755551,-0.026364941,-0.06089752,-0.1577585,-0.04141601,0.037502196,0.067055784,-0.015617491,0.06621701,-0.019529339,-0.042772975,-0.008344628,0.009091429,0.01050045,-0.05150108,0.10931558,0.09300376,-0.069618784,0.03367419,0.046400882,0.01282199,0.015411667,0.04668882,-0.16297993,-0.018746229,-0.0103191715,0.077390246,-0.043717775,-0.09831101,-0.010041483,-0.03819048,-4.282899e-33,0.06326257,-0.01663935,0.05990675,-0.032759994,-0.09345142,-0.014228894,0.020277414,0.005739143,0.06031578,-0.044516895,0.06382945,-0.06222209,-0.0119625265,0.008789821,0.002676239,0.022629287,0.022680042,0.035865776,-0.023968771,0.06434455,-0.031644907,0.061216515,0.08287606,0.090984136,0.09236957,-0.027069302,0.0037623146,-0.050350588,0.014262881,-0.013236231,-0.011687303,0.04907252,-0.012937275,-0.06252672,0.025327193,0.03367288,-0.05609955,-0.00925755,0.028301539,-0.06984542,-0.025769794,0.10850317,0.06759956,0.05441687,-0.02703627,-0.020725887,0.0056553185,0.03878619,-0.086861275,-0.06834844,0.009220307,-0.015335742,0.04030831,0.09063551,-0.041828368,0.009815195,0.036960084,0.08295677,-0.016498413,0.0033787072,-0.09480171,-0.015244646,-0.0052764476,-0.026916435,0.05992956,0.0630923,-0.043430943,0.076280236,0.05653144,-0.05533841,-0.05972965,0.024393613,0.015590786,0.06139025,-0.03553525,0.0044622226,-0.046827152,-0.004534122,0.002154263,-0.0463333,-0.097207986,0.020740043,-0.07647572,-0.009346128,0.08468956,-0.043832596,0.05576475,0.091678515,0.023052506,0.039059736,0.043502055,0.0071292305,-0.0070357854,0.01621949,0.005200245,-2.7923104e-08,0.08050464,-0.019803755,0.03287669,-0.15480722,0.0074226866,-0.034601644,0.040386796,-0.028210606,0.0015067271,0.0013344778,0.064772464,0.05296051,0.040231317,-0.06426377,0.092821926,-0.008894606,-0.08329499,-0.011050767,-0.03739988,-0.036048636,-0.032566298,0.0405933,-0.04072481,0.076404124,-0.00217414,0.034535598,0.09530639,-0.050647613,0.029917834,-0.017609887,0.0038731778,-0.018003572,-0.03883098,-0.07421216,0.038374454,0.08914209,0.039682347,0.020898292,-0.058220435,0.010996446,-0.1580324,-0.064456895,0.025450384,0.0080954805,-0.1022282,-0.08245306,-0.024978803,0.005995094,0.027566843,-0.03128476,0.019115116,0.029877596,-0.041550342,-0.055515733,-0.09686721,-0.06381763,-0.00967123,-0.07829108,0.04952605,-0.027749017,0.04389442,-0.016545,0.06355873,0.03706187 +3.6.1.27,"Isolated from the bacteria Micrococcus lysodeikticus [1], Escherichia coli [2,3,5,6] and Bacillus subtilis [4]. The product of the reaction, ditrans,octacis-undecaprenyl phosphate, is essential for cell wall polysaccharide biosynthesis in these strains.",384,0.99999994,-0.13004093,-0.059905276,-0.10040463,-0.05475491,-0.0053296983,-0.024365876,-0.04742395,0.047794055,0.092185035,0.036448717,0.03462259,-0.029078571,-0.021461697,0.04151902,-0.09556352,-0.022616433,-0.021197118,0.05250768,0.01801836,-0.006333562,0.10271153,0.041526217,-0.070706934,-0.035203293,0.053972848,0.008286672,0.06662595,-0.019312616,0.022366209,-0.04532218,-0.016736863,-0.059360348,0.06974817,-0.08578799,0.09080521,0.12520169,-0.015718658,-0.02013171,0.14862911,0.0023394576,0.0019357732,-0.012862058,0.05094146,-0.037124455,0.0089166295,0.010556349,-0.050841473,0.05506364,0.033004053,-0.054081544,-0.0036267296,0.014372653,-0.036725756,0.039230984,0.08449318,-0.07179417,-0.041183393,-0.008330989,0.049842305,-0.016578699,0.079587415,-0.0012594274,0.05432929,-0.003981448,-0.10816313,-0.04415724,-0.012126779,0.009273021,0.022883022,0.0018617825,-0.048995793,0.058254562,0.056291543,-0.003070037,0.017378656,0.032569755,0.0048208633,-0.036057286,-0.029941397,-0.00061715505,0.04540323,-0.026315013,-0.02861512,0.11955355,-0.0070607276,-0.0719948,-0.012146664,0.030245366,0.015739676,0.022069471,-0.0056946063,0.06946314,0.043857157,-0.0835317,-0.044740606,-0.057941116,-0.024300512,0.01898024,0.05408672,0.0011159839,-0.037497357,-0.03462596,0.051615022,-0.06732914,-0.09762082,-0.036565866,-0.011209047,0.039875336,0.08602743,0.04365854,-0.024585301,0.06777227,-0.054636743,-0.02263872,-0.056200873,-0.0013242166,0.09016194,-0.14339475,0.014612088,-0.035676785,-0.007625308,-0.03767077,0.097279795,0.0169942,-0.07869348,0.025099909,-0.02352763,2.5384283e-33,0.0026209326,-0.01632193,0.009499839,-0.004342043,0.071782194,-0.012176061,0.010417092,-0.084013484,-0.0363802,-0.086111836,-0.10050685,-0.06962243,0.040849615,0.060884744,-8.864245e-05,0.017214336,0.045575418,-0.055584267,0.055863094,0.024906635,0.03290518,0.0708937,0.0044049863,0.02466022,0.05133688,-0.007938537,0.011467536,-0.015665865,0.05007016,-0.009378134,0.07937619,-0.073327154,-0.025071228,-0.028797656,0.06975779,0.010467488,-0.11807083,-0.00906835,0.02741591,0.012498531,0.040787566,0.053099833,-0.012604046,-0.013681575,0.069542944,0.04343104,0.002963034,0.013090481,-0.012020464,0.017998789,0.035968836,0.03095471,-0.04817591,-0.08405887,-0.05493529,-0.029288108,-0.038412437,-0.0057839626,0.045782432,0.07439932,-0.011787666,0.112742834,-0.035497442,0.049967326,-0.012968699,-0.0364842,-0.046029676,0.006052186,-0.015264175,-0.004398306,-0.029993549,-0.064567454,0.009672262,-0.030166892,0.008821029,0.01010867,-0.048107635,0.020092037,0.009132249,-0.04700945,0.08045235,0.0288938,0.0030225418,-0.026076209,-0.07065669,0.08592452,-0.040657252,-0.022626266,-0.007873197,0.10107988,0.015903514,-0.13221496,-0.061909616,0.032767333,-0.026748495,-4.3306534e-33,0.06036115,-0.08347862,0.055837344,-0.041495018,-0.047756366,0.06119232,-0.0004946753,0.022558598,0.06090765,0.047059786,0.02600742,0.040387064,0.042238276,0.018867603,0.003887074,0.06199885,0.05165812,0.082186975,-0.02211187,0.00407571,0.033066154,0.038572576,0.02254304,-0.060026277,0.020788109,0.028096067,-0.002562972,0.09035586,-0.0040632603,-0.014657448,-0.044789024,0.0107743945,-0.049382586,-0.043757666,-0.090799965,-0.058762338,-0.0716094,-0.075699575,0.024415899,-0.029727388,-0.025668392,0.038076065,-0.010472742,0.07313659,-0.009667364,0.015307813,0.007480834,0.039061736,-0.03952181,0.0021700177,-0.04595294,-0.023436533,0.018485539,0.009886287,0.027488336,0.0043675117,0.02040552,0.13703443,0.027105799,-0.017669018,0.00026217286,-0.08814322,0.033599857,-0.04003904,0.10710498,0.1542896,0.0014324647,0.04740765,0.0012889752,-0.090804495,0.06840738,0.042412642,-0.056950487,-0.026902763,-0.007935983,-0.0001878761,-0.11779047,-0.04367694,-0.012928944,0.07718018,-0.022149865,-0.033479575,-0.012992627,-0.025841538,0.038665544,-0.0701226,0.08551546,0.080903925,-0.038052935,0.017164445,0.01059999,-0.009943071,-0.008002288,0.017512476,0.10419653,-4.141393e-08,-0.009770555,-0.09733261,-0.031702757,-0.062256612,-0.09479027,-0.03893129,-0.00020376832,0.0019386548,-0.01554615,0.022860782,0.027288489,0.0036596053,-0.03128314,0.01970767,0.0491142,0.06896104,-0.019250432,-0.016853372,0.01703966,0.023451118,-0.04655628,0.029564599,-0.052807078,0.05896458,-0.011785625,-0.08152775,0.046512436,-0.08901752,-0.029294126,-0.049984977,0.02852212,0.07052129,-0.066430084,-0.09907793,-0.05036953,0.0052367,-0.047230534,-0.004433068,0.016019076,-0.009974063,-0.0030342753,-0.008555759,-0.046977308,0.053523377,-0.052424405,0.024832672,-0.06882387,0.06510642,-0.08180256,-0.029810512,0.043231405,-0.05573105,-0.012004653,-0.0386169,-0.06056539,-0.041501295,-0.0030380615,-0.087784715,0.000841268,-0.015494875,-0.015704116,-0.001511783,0.14645621,-0.001943934 +3.6.1.31,The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase).,384,1.0,-0.037460696,-0.020150559,-0.06341428,-0.0447353,0.04913907,0.057160106,-0.05623718,-0.0053321994,0.044782016,0.017248275,0.030045846,-0.11676349,-0.021261329,-0.015718587,-0.069779,-0.013173458,-0.09057322,-0.042284813,0.0066554905,-0.124698795,0.03657821,-0.0048315944,-0.016843662,-0.010764827,0.0055435775,0.008093746,-0.019116899,-0.00697526,-0.03861663,-0.052286383,0.047171734,-0.0670777,0.05472629,-0.062125545,0.026675388,0.10098031,-0.08821843,-0.08269246,0.044661857,0.07478822,0.0040372815,0.017135741,-0.022937607,-0.0076753255,-0.0060127857,-0.0051592914,-0.0006299404,0.03276992,0.06671924,-0.074540555,-0.016010605,-0.056079112,0.056548085,0.02784696,0.034346934,0.07280398,-0.09863314,0.0013978829,0.0469635,0.039749995,-0.0009301092,0.05600849,0.015395928,0.030166017,-0.0025335778,-0.03550247,0.008024092,-0.105687216,-0.013893791,0.04920149,-0.076889046,-0.05523582,-0.025777183,-0.016477231,0.010645465,0.03364006,-0.059435185,-0.08675346,-0.016645301,-0.01970498,-0.026546627,0.010667832,-0.0020376218,0.015770426,0.086423755,-0.0018929036,0.061607458,-0.0338664,0.04601058,0.06525239,0.040277824,-0.08647177,0.017372709,-0.017349664,-0.06048181,0.088508114,0.0049943416,0.10253061,0.053089917,-0.056160558,-0.022441644,0.113612294,-0.038911074,-0.07552894,-0.030085701,0.07960701,0.033199307,0.12633136,0.029043192,0.044272657,-0.027380107,-0.07490593,0.02894111,-0.021239989,0.0051589566,0.1302888,0.04620978,-0.022628909,-0.049846265,-0.0027553728,0.041593928,-0.069975086,-0.035595845,0.05864055,-0.004914499,0.06975921,-0.1597488,2.7833787e-33,0.010699563,0.034941263,-0.058945157,-0.03826951,-0.00012922638,-0.014764483,-0.086194046,0.076402746,-0.029189726,-0.066918954,-0.061083775,0.024269344,0.073427945,-0.04428352,-0.10409884,0.017876327,0.015837189,-0.02849139,0.012510471,0.0032085127,0.004904262,0.001878211,-0.02940931,-0.007842945,-0.0022041823,-0.009807944,-0.028624313,0.039038677,0.06521222,-0.013026755,-0.024003077,-0.07395366,-0.07863472,0.044274576,-0.016138777,-0.046529178,-0.0021231528,-0.05943209,-0.027500337,0.053380903,-0.021448111,0.04414079,-0.0007590325,-0.057679858,0.044551756,-0.0074514514,-0.009039989,0.07803532,0.12942776,0.023207923,0.024640648,0.017677862,0.116782054,-0.056726053,-0.020458328,0.059115537,-0.028909491,0.0144371055,0.09187939,0.120436415,-0.04674974,0.081023626,-0.02272904,-0.027923826,0.051215574,0.023448726,-0.011365422,-0.06727531,0.014492898,-0.0086544985,-0.097485736,0.02798227,0.00072755315,-0.007013732,0.07829706,-0.06051998,-0.028951472,-0.037702065,-0.054439984,0.079587705,0.00083147065,-0.011188864,0.06319412,0.002490824,0.01493435,0.007661317,-0.045481768,-0.0050191097,0.021101195,0.026126914,0.006761498,-0.12195641,-0.011126708,-0.006861737,0.019653982,-2.4717399e-33,0.056617737,-0.073662154,0.017505758,-0.06299987,-0.05591124,0.11968734,-0.0075782696,0.0154809365,0.017669542,-0.019003242,0.04901456,-0.016230308,0.03545579,-0.072591074,0.0047085714,-0.045984797,-0.0026919376,0.059797984,-0.032799043,0.0032799393,-0.008489204,0.12255589,0.021763718,0.025095671,0.06501144,0.032994136,0.02095624,0.08172944,0.00967512,0.040380903,-0.054795936,-0.0067216703,-0.061149206,-0.0012734863,-0.025956139,0.018538428,-0.092872776,-0.020017155,0.05836117,0.04420371,0.059470445,0.036965452,0.0649782,0.041322388,0.008684062,0.07926061,-0.08447691,0.112107016,0.011386867,-0.037244488,-0.024336815,0.027236985,-0.043583542,-0.0022834237,0.0849001,0.07042363,0.04320714,0.010486037,0.041723598,0.0077738366,-0.018051004,-0.0065180687,0.04853336,-0.0010568142,-0.018353645,0.058759596,-0.07555792,0.05569723,0.014423647,0.05604623,0.06263167,0.0038570305,0.0071496633,-0.019034276,-0.031566467,-0.011945276,-0.05080839,-0.023091558,0.02581974,-0.03249333,0.06451876,0.020720417,0.019131972,-0.06283731,-0.001753708,-0.013808144,-0.023287114,0.033326585,-0.042114284,0.039586022,0.004345694,-0.031683147,-0.018125053,0.0817921,0.07811498,-3.205471e-08,0.07139457,-0.010380762,0.0868282,-0.053349018,0.064237446,0.033214025,0.02725957,-0.043458287,0.005753535,0.014130153,0.016780298,-0.0015787075,0.055431757,0.012919427,-0.01997003,0.05334638,0.0053654094,0.047047857,0.00034304574,0.0370291,0.003313376,-0.040345386,-0.09129798,0.064796984,0.04862668,-0.08785782,0.0652578,0.059187595,-0.047902107,-0.05732358,-0.06437409,0.012383462,0.03177821,0.0027063459,0.04073128,-0.025962843,-0.10725765,-0.03328823,-0.07590221,-0.016094977,0.0005263902,-0.045763034,-0.0026332338,-0.016795095,-0.06679279,0.033961464,0.0063639805,0.005832198,0.010311224,0.015023761,0.07264654,-0.08498031,0.057354532,-0.05707221,-0.055832915,-0.052122053,-0.012750008,-0.13610776,-0.015168693,-0.03311418,0.0035950535,0.010160887,0.16315758,-0.011707943 +3.6.1.39,"Also acts, more slowly, on dUTP and UTP.",384,1.0,0.01716758,-0.11612353,0.08191839,-0.016472803,-0.036139462,-0.041851006,-0.0024195833,-0.010885019,0.09244397,-0.013164465,0.03195082,0.09224003,-0.01083247,0.098741144,0.055654906,-0.039520007,0.049756188,-0.033936262,0.0043501216,0.013638007,-0.014691433,-0.020014452,-0.029180698,-0.075455636,0.0012798999,0.011306535,0.0033825873,0.027709758,0.0016735467,-0.1504146,-0.013776056,0.024818446,-0.05145917,-0.052090187,-0.068135776,0.079072446,0.007861164,-0.0055494243,0.02869006,-0.016673911,0.025651706,-0.0782852,0.004949159,0.028945647,0.020728478,0.023707116,-0.011273686,0.0051632496,0.017959801,-0.080460936,0.020641726,0.022281844,0.061985247,0.05878892,0.051637765,-0.046769846,-0.06720731,0.055464454,-0.01651922,-0.017731316,-0.11512797,0.08812903,0.0031591821,0.044282828,0.07321005,0.0917126,0.015773911,-0.00039895988,0.011157305,-0.000543729,-0.031716283,0.023491215,-0.101778105,0.023841344,0.059983198,-0.06271314,-0.035442017,-0.022145346,-0.073686585,-0.033344604,-0.02240251,0.0064851404,-0.054830555,0.00452614,0.037958406,-0.047482733,0.034721218,-0.076383665,-0.13380289,-0.034712043,0.090192795,0.03861561,-0.019516053,0.042995516,0.0156039605,0.012511465,-0.0747071,-0.00020886255,-0.061585497,0.020290742,-0.007213112,0.053499788,0.0115009155,0.06361879,-0.011236363,-0.03849051,0.09012696,0.037032515,-0.03147884,0.022205068,0.01324975,-0.010394952,-0.03751212,0.082825735,-0.014120952,0.045939248,-0.086169936,0.016727114,-0.033595785,-0.012245837,0.02585174,-0.017342903,-0.079456784,-0.0043023955,-0.024466043,0.074451484,-0.020872785,-3.8081033e-34,-0.051059682,-0.017400598,-0.041789465,-0.048269764,-0.04861799,-0.03862968,0.00046403505,0.018654112,0.027326683,-0.097937696,-0.08916048,-0.03730935,0.022402683,0.008512597,-0.05463385,-0.107473746,-0.03184099,0.08878322,0.013361243,0.02675395,0.0665195,0.084873594,0.011203529,-0.04847439,0.034253977,-0.04459126,-0.035942633,-0.018100863,0.020322464,-0.016232505,-0.0050877966,-0.010741398,-0.07831141,0.035170373,0.012494533,0.11327077,-0.016691947,-0.013004359,-0.018003628,-0.013965934,-0.074207895,0.028896106,-0.122333944,0.043712724,0.027506504,-0.0788068,-0.038263384,-0.060194694,-0.06623432,0.09896939,-0.019149093,0.006891125,0.0051812055,-0.03243879,-0.035135597,0.007284318,0.045936294,-0.04275383,-0.03761953,0.101171225,0.08299484,0.028694361,-0.0644529,-0.050869815,-0.0023373154,-0.028055262,0.009923459,-0.007130124,0.022453923,0.056457993,-0.0011071406,0.04229787,0.14057009,-0.025233535,-0.028356869,-0.042559937,-0.052979022,-0.02643871,0.03741928,0.010365151,-0.04128396,-0.10230692,0.044273853,-0.011320676,0.02701176,0.06577479,0.035219707,-0.06772942,-0.058194693,0.0041919886,0.07314865,0.060760494,0.005448647,0.017697318,0.026227431,2.2707709e-34,0.0029909567,-0.06918594,0.038676966,0.10091008,-0.030744746,0.069564715,0.041516658,0.050623626,-0.030589094,0.046032134,0.034425814,-0.04238816,-0.00017543818,-0.010913422,0.049836338,-0.006176433,0.111796856,0.017654639,0.021857105,0.029777663,-0.021859473,0.14862005,0.037401754,0.060710084,-0.011103917,0.027205886,-0.08927811,-0.0045379587,-0.048723254,-0.033159327,0.026305903,0.018920366,-0.11410279,-0.0038002103,0.000590368,0.0620074,-0.04883278,0.0831613,-0.011143701,-0.015070409,0.06704841,-0.01276521,0.014497738,0.047910575,0.032563858,0.05752479,-0.012864574,-0.030286228,-0.053189285,0.06515644,0.07894373,0.017188396,-0.0062221694,0.036899086,0.015165872,0.013523137,0.009812822,-0.06924675,-0.018787222,0.025954245,0.01744406,-0.009581978,-0.022325631,-0.02720123,0.09447852,-0.03071122,-0.0015544642,-0.031347208,0.14041656,0.026656661,0.03294257,-0.06304787,-0.019655075,-0.03921573,-0.02948407,-0.0380549,-0.066999875,-0.04845724,-0.033377055,-0.019617792,-0.09133309,0.00010383901,-0.018348476,0.0065646027,-0.14649487,0.06306945,-0.030658692,-0.049109936,0.03023217,0.023410872,-0.02591353,0.022718525,-0.04648776,0.06906822,-0.09281564,-1.834061e-08,0.004362873,-0.043812677,0.012313424,0.04308717,0.05084083,-0.018965093,0.018477181,0.056500208,0.007797617,-0.0010611332,0.030552255,-0.03191061,-0.01422329,-0.06654168,0.16463149,0.012712641,0.029260585,0.028558884,-0.058476537,-0.030239534,0.002043109,-0.005776776,-0.05693077,0.04748805,-0.029289287,0.04398944,0.043325998,0.07726788,0.020215569,-0.118520446,0.031495325,-0.06634937,-0.034546886,-0.05519556,-0.03195716,0.09511281,0.071852624,-0.0056454903,0.005692806,0.06203294,-0.011833951,-0.038646102,0.024070973,0.036042098,0.016855711,-0.012033814,-0.019442149,-0.036862634,0.034027144,-0.11224069,0.08509704,-0.038663734,0.04309993,0.04349459,0.051862497,0.04203175,0.021037657,-0.06783356,0.07646518,0.06681277,0.06353943,-0.0010794537,0.046807233,0.048295155 +3.6.1.40,"Also hydrolyses other guanosine 5'-triphosphate derivatives with at least one unsubstituted phosphate group on the 3'-position, but not GTP, ATP or adenosine 5'-triphosphate 3'-diphosphate.",384,0.99999994,-0.11606638,-0.08280246,0.031055273,-0.067058794,0.0005589872,-0.038903788,0.0362337,-0.0026133426,0.030108184,0.011085968,0.045036905,0.0068839784,-0.07687164,0.057644047,0.006460423,-0.043064352,-0.0147612225,0.04882067,0.08062525,-0.027132366,0.071601376,0.01695115,-0.00657882,0.04937387,0.030742666,0.08167491,0.06615664,0.055237297,0.044947244,-0.057562325,-0.11674973,-0.022328774,-0.036480263,-0.06053912,0.035104766,0.14886342,-0.06352234,-0.0099897785,0.0019114832,0.029248588,0.08196063,-0.038364235,0.015304323,0.025438868,0.011544153,-0.026286773,0.01606207,0.018915033,-0.0399962,-0.022190986,0.03418039,-0.045479465,-0.03740896,-0.013218712,0.010200627,-0.058140203,-0.10044916,0.04015739,-0.020687135,0.011378913,0.01907649,-0.0036838185,-0.04052085,-0.01995463,0.022685165,0.026983341,0.030942237,-0.01024177,0.011265348,0.07676016,-0.031656772,-0.015933922,0.029079214,0.017035654,-0.103003755,0.102966554,0.024268644,0.010294879,0.035233982,-0.042608067,0.059900574,0.00379722,0.06688295,0.052353233,0.06241471,-0.030453647,-0.08138453,0.07155662,-0.00043223615,-0.011314573,-0.0017575589,0.013541323,0.036984693,-0.043689754,-0.050576806,0.03494688,-0.036805186,-0.023978047,-0.05236925,-0.011708089,0.031731654,0.06595952,0.0116907675,-0.043330453,0.025600718,0.048278645,-0.04491844,0.020307517,0.025474433,0.024496892,-0.12496065,0.054954678,-0.018660968,-0.02325226,-0.07973729,0.016939295,-0.07961999,-0.04852807,-0.00038770828,0.0077353623,-0.011581252,-0.08728873,-0.040968202,0.047742862,-0.08471528,0.040846586,0.0061816615,4.5550645e-33,0.026084125,-0.011965176,0.024764165,-0.035109285,-0.004569972,0.06897549,-0.07826726,-0.039190605,-0.07948783,0.0064387685,-0.011378859,0.009539469,0.045770355,0.017756984,-0.008932758,0.01868472,-0.06771725,0.060024153,0.08732788,-0.082840614,0.013467826,0.089009695,-0.061325833,-0.00026138933,-0.0077883354,-0.0042330325,-0.09414601,-0.03231587,0.06867155,-0.02213169,0.020982327,-0.06565222,-0.064822845,0.017928267,0.027778924,-0.03536958,-0.07827402,-0.07943539,0.058358833,0.038743995,-0.036522206,-0.011427492,-0.0049990453,-0.016018244,0.008785631,-0.027492618,-0.017142463,0.0041307462,-0.023745602,-0.017887058,0.03985846,0.005439884,0.012525975,-0.02541011,-0.01570097,-0.049564864,-0.0031850762,0.049088333,0.013534784,0.028154867,0.04804944,0.058463704,-0.009716308,-0.09428932,0.00038962608,0.04685427,-0.09947582,-0.06431029,0.058066323,0.102709085,0.010887772,0.0015641963,0.044065375,0.045626935,-0.0032126608,-0.05074157,0.040503465,0.0252023,-0.032388758,0.09155549,0.0036977911,-0.08566004,0.0018803006,0.025424734,-0.075648434,0.055504743,0.043884702,-0.060042445,0.030654982,0.009486951,0.03302341,-0.033833098,-0.024350574,0.0033646296,-0.050207637,-4.451775e-33,0.08113433,-0.033763338,0.009486539,-0.046910346,-0.06915319,0.005012747,0.068352014,-0.1327545,0.011992521,-0.046073448,0.09801796,0.012537388,-0.020314524,-0.039967608,-0.03759582,0.049509834,-0.023664214,0.029644888,-0.012510344,-0.016302286,0.052050486,0.05586488,0.026129516,0.09406722,0.05312713,-0.0023156507,0.011152906,-0.0015610477,0.032438204,0.091787666,-0.08710507,0.02581626,-0.069822244,-0.04371939,-0.02379171,-0.021430586,-0.008218096,0.059476115,-0.026622215,0.0122548025,0.015205373,0.10569154,0.11454822,0.066541865,0.022570033,0.12508988,-0.019920722,0.018899614,-0.07226596,-0.025248516,-0.0492377,0.025230812,-0.11918256,0.06562604,0.031881902,0.002941498,-0.017919172,-0.05217453,-0.05101908,-0.0642063,-0.017713547,-0.06868682,-0.0028631478,-0.13019073,0.05320199,0.12038799,-0.027600238,0.038648617,0.010245825,0.026801948,-0.048614025,-0.05114555,0.06684717,-0.026349572,0.00647653,0.022416454,0.02802334,-0.030901032,-0.03115062,-0.119742624,0.043907344,0.08643078,-0.084567994,-0.02518496,0.008963428,0.0030073244,0.009184635,0.10803424,0.1013268,0.051164053,0.0059843557,0.00036583262,0.032068912,0.09673228,0.08184556,-3.3321363e-08,0.02710196,-0.005025141,0.08488891,-0.01314853,-0.018008567,0.05733319,0.003572818,0.067821085,0.09022913,-0.012825342,-0.01919171,0.025089737,0.025416156,-0.04104027,0.06778652,0.052287817,-0.04577975,0.06743498,-0.02625083,-0.08540316,-0.084116876,0.018937962,-0.07064097,0.06846716,0.013537493,0.023438126,0.008176578,-0.071132496,0.026080089,-0.027254347,0.048641235,0.01152511,0.03660617,-0.035456542,0.054850414,0.059630964,-0.04862761,0.060443774,-0.11534805,-0.006237876,-0.08628383,-0.057913195,-0.023939561,0.06229454,0.00085025176,-0.021948393,0.0038610299,0.031703077,0.0042499,0.047092486,0.024265751,-0.019416444,-0.01242796,-0.06483358,-0.029076789,-0.056374267,-0.03196309,-0.06989512,-0.07106631,-0.061502956,-0.015586159,-0.027353765,0.12494469,-0.020606138 +3.6.1.41,"Also acts on bis(5'-guanosyl) tetraphosphate and bis(5'-adenosyl) pentaphosphate and, more slowly, on some other polyphosphates, forming a nucleoside bisphosphate as one product in all cases [cf. EC 3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)].",384,0.99999994,-0.039122093,-0.09054784,-0.021539107,-0.041122194,0.019942382,-0.034684733,0.091988705,0.012655155,0.07767801,0.05822075,0.03603355,0.024218315,-0.021384154,0.08825487,0.0010958337,0.009900263,-0.056980923,0.023737976,0.029787213,-0.066307575,0.07180743,-0.0424332,-0.0062048477,0.01887316,0.0062752706,-0.02766455,0.049902882,-0.006747739,-0.013960444,-0.095026836,-0.09744875,0.0074075535,0.028147131,-0.0620981,0.03232394,0.09933859,-0.08245413,0.010124026,0.0031107925,-0.025301768,0.11912417,-0.06899468,0.0024237316,0.006302807,-0.023751661,0.031547993,0.030826172,0.051364653,0.011355722,-0.0020094637,-0.038085844,-0.0789458,-0.050321214,0.011217012,-0.006321386,-0.014965626,-0.074878246,0.09304737,0.02677669,0.06043583,0.0074882642,-0.061431356,0.009299981,0.047537304,0.07867144,0.03316783,0.06327655,-0.04763825,-0.029385332,0.02040806,0.026807062,0.018615665,0.036005385,-0.018311245,-0.049736194,-0.002825789,0.026160885,-0.029484164,0.03131704,0.00067098177,-0.08740609,-0.0029215915,0.047228474,-0.059170544,0.06855692,0.025612865,-0.08325102,-0.0075549306,-0.03294586,0.01345415,0.04054139,0.03742408,0.026692346,-0.09163518,-0.01213458,0.01282531,-0.019048603,0.017298583,-0.008902448,-0.026320886,0.03677947,0.07681346,-0.06714427,-0.035830826,0.038804978,0.058827266,-0.02267166,-0.102862425,-0.039394047,0.06250219,-0.05365766,-0.0026185373,0.049883574,0.026684292,-0.071945064,0.050695803,-0.06748496,-0.021497354,0.0062357965,0.0059892377,-0.019675484,-0.063122064,-0.099376656,0.0857993,-0.06185118,0.10461986,-0.04670443,4.7534923e-33,0.048766755,0.026939096,0.009216739,0.021070667,-0.010103721,0.0117367925,-0.002198737,-0.06191078,-0.10667229,-0.0054744077,0.030022264,-0.04436545,0.09398658,0.0072458056,-0.018090092,-0.025224224,-0.03657565,0.089306265,0.06485246,-0.05112451,-0.018000497,0.1241315,-0.083491854,-0.0045977486,0.0017300007,0.02372357,-0.13672154,0.052616876,0.033600625,-0.01731245,-0.0042737396,0.013386506,-0.09317615,0.0316282,0.054241955,-0.064858146,-0.049428616,-0.039782424,-0.004650157,0.037629593,0.029600726,-0.020558195,-0.032334488,0.039908905,0.019953044,-0.036951844,-0.026234102,0.025762947,0.11165801,0.012047015,0.033637453,-0.0108614685,0.06507182,-0.09311025,-0.018132512,-0.042655084,-0.021203436,-0.10588433,0.0051417216,0.06142436,0.0066078813,-0.010030035,-0.038690753,-0.053537097,-0.03926823,0.041263618,-0.06630649,-0.0864735,0.035043053,0.037232973,0.062385928,-0.017219841,0.056270916,0.02106311,-0.0029671039,0.03921864,-0.0034639968,-0.062461946,-0.029513255,0.07336481,0.02045818,-0.054641232,0.014919807,-0.065106176,-0.07715316,0.023162019,0.052131902,-0.12802799,0.007185011,-0.003777919,0.031414054,-0.06779935,-0.07999084,0.04950674,-0.029718019,-5.7541907e-33,0.058965262,-0.059760433,0.05426209,-0.06778911,-0.09553543,0.00694982,0.05202632,-0.12522836,0.058830116,0.0065173465,0.062344145,-0.07608789,0.026027301,-0.023037584,-0.04778844,0.062849306,0.075535186,0.06029382,0.022648484,-0.015550093,0.021073567,0.07594496,0.06382556,0.120820105,0.031722363,0.020764336,1.4320434e-05,-0.030818027,0.018310372,0.061764803,-0.09844175,-0.021629872,-0.04887998,-0.011834569,-0.029387945,-0.019083936,-0.051359266,-0.022244262,0.02385206,-0.035749458,0.05140089,0.043169137,0.13119842,0.093482934,0.0013684173,-0.01227208,0.0019850757,0.07290969,-0.104972385,-0.02454789,0.022034703,0.025860216,-0.0146519495,0.060966805,0.02511054,0.052526433,-0.008878741,-0.0018791346,-0.053994972,-0.041671515,-0.016756915,-0.093688235,-0.001190897,-0.069299705,0.07677783,0.082288004,-0.032998193,0.00058604125,-0.00026389246,0.027114447,-0.016320994,0.032770716,-0.0032326898,-0.019322326,-0.07489924,-0.0465028,0.013377891,-0.021583723,0.0053694365,-0.019952849,-0.055824775,0.06796073,-0.03660103,-0.04436048,-0.024409814,-0.025783608,0.032848753,0.08108937,0.05256656,0.06147899,-0.02911921,-0.0064963475,0.021916358,0.06342203,0.10011361,-4.4597215e-08,0.05868495,-0.037482105,0.025363686,-0.06910149,0.008958563,0.015461735,0.011165304,-0.007997726,0.04466511,0.018824551,-0.04094603,0.050140925,0.07159058,-0.014290782,0.11424945,0.038512386,-0.07891034,0.014287227,0.01725048,-0.09564292,-0.025025396,-0.0323846,-0.06687121,0.070217125,-0.056204293,0.053183,0.030546095,0.040006075,-0.032546062,-0.02757865,-0.00969473,-0.04671724,-0.009105693,-0.06748394,0.06595652,0.04195867,0.012416289,0.0051909797,-0.07002797,0.06883987,-0.10019136,-0.042876195,-0.020484261,0.06748076,-0.044772543,0.0027286243,-0.001177131,0.032926872,0.0055063036,-0.012604549,0.05322069,-0.054332487,-0.01648611,-0.06172436,-0.04747999,-0.0712697,-0.0007537002,0.0016249141,0.012946098,0.056696277,0.034730654,0.01488444,0.119002946,-0.06548157 +3.6.1.42,Also acts on UDP but not on other nucleoside diphosphates and triphosphates.,384,1.0,-0.057916243,-0.08168392,0.050305072,-0.06273506,0.026869299,-0.061630085,0.0024735185,0.051500037,-0.019928172,-0.005963209,0.04214441,0.015965356,-0.049069706,0.0836113,-0.019106511,-0.0144349225,0.0035375915,-0.00628436,0.08240421,-0.02217037,0.06213913,0.04011871,-0.017346164,-0.044972442,0.0059363283,0.02264895,0.08444959,0.015942277,0.028589457,-0.11290555,-0.06657786,-0.00083671923,-0.016305199,-0.076525,0.08463506,0.11813907,-0.055221457,0.00040050218,-0.012965681,-0.01593841,0.13053033,-0.055025954,0.024217207,0.0269547,-0.029752651,0.004854172,-0.012972537,0.03315915,-0.028258163,0.0154535435,-0.014950582,-0.028025744,0.02688881,0.046208087,-0.012996088,-0.03343282,-0.073547006,0.03424796,-0.012789936,-0.0050019403,-0.083050996,-0.021235006,-0.014722963,-0.010908804,0.1447166,0.052239116,0.083711885,-0.009331016,-0.04827435,0.03009499,-0.0043679816,0.009909166,-0.032802623,0.0544181,-0.0042877914,0.06922368,-0.026779218,-0.032967556,0.05276127,-0.042458132,-0.04867038,-0.0027114807,0.034954533,-0.026483377,0.032675594,-0.0010839584,-0.06436928,-0.018819654,-0.07702831,0.009912414,-0.00022573033,0.09087636,-0.008714904,0.014049721,-0.06401107,0.04261453,-0.0059797266,0.058920138,-0.045785688,-0.033279747,0.013980876,0.06387788,-0.12709118,-0.07253384,-0.0023217145,0.0061359215,-0.0327508,-0.0986736,-0.052029785,0.075015165,-0.030201137,0.025435701,0.049107052,-0.012914992,-0.021963157,0.029355962,-0.016856002,0.025606202,-0.07989028,-0.064023435,-0.037816674,-0.093211085,-0.00046697442,0.068741456,-0.03927411,0.021800606,0.010971219,1.1380914e-33,0.048600886,-0.04009787,-0.043409027,-0.048212342,-0.029574037,-0.0024831756,-0.015730675,-0.0057964134,-0.06853988,0.0024383462,-0.05055307,-0.07991057,0.11263289,0.01446088,-0.028491415,-0.00300665,0.033162255,0.046896752,0.0283363,-0.016551025,0.030680593,0.087382205,-0.009239781,-0.009426503,0.017824747,0.03734365,-0.12980743,0.022109011,0.07123167,-0.02349119,0.034367055,-0.02354146,-0.09356615,0.049958136,0.06616367,0.017985165,-0.06626136,-0.054665476,-0.024753083,-0.031067166,-0.005245614,-0.022894073,-0.06556884,-0.0037752124,0.020816527,-0.034974292,-0.045992307,-0.046115775,-0.017940275,-0.043496635,0.058685858,-0.032722086,0.07216245,-0.07092327,0.049467474,-0.04094186,0.022451552,-0.022620438,-0.025886627,0.121055715,0.030675005,0.051549617,-0.016146762,-0.052859575,-0.0021225852,0.060557213,-0.086259075,-0.059178993,0.06220633,0.029864192,0.050181415,0.025449712,0.07798053,0.04536837,-0.028964816,0.0005485194,-0.046883147,-0.0042821513,0.042462204,0.05278681,0.006891383,-0.08527556,0.034301918,-0.03719148,-0.023390165,-0.033674005,0.020948565,-0.0439083,0.02182626,-0.006098356,0.11272313,-0.031056762,-0.053874034,-0.02992449,-0.001685523,-3.3554115e-33,0.003969529,0.02349544,-0.06912425,0.012245925,-0.07133445,-0.0074615595,0.055645734,-0.035728417,0.034882393,-0.021889733,0.058203027,-0.060665794,-0.061927684,-0.00043595486,0.025391132,0.06998336,-0.0154413795,0.07145065,0.009928126,0.0007137717,-0.07803062,0.122976825,0.052963182,0.14176898,0.019528408,0.023449615,-0.03660407,0.0036252728,0.040779863,0.017526664,-0.0177572,0.045412693,-0.12372848,-0.092006594,0.015272034,0.016236493,-0.010840207,-0.015921544,0.049014866,-0.02748085,0.071148574,0.044644356,-0.023997178,0.049284384,0.021682637,-0.013340246,-0.0050864555,-0.0033977905,-0.12244984,-0.04237547,0.041611105,0.004027219,0.029023008,0.045709167,0.01880414,0.097878926,0.040701676,-0.012536466,0.0074145542,-0.026564287,0.015635889,-0.10440962,-0.075321466,-0.05103264,0.06730604,0.093069516,0.010773896,0.0050351466,0.06512643,-0.02332874,0.0024354444,0.04051858,0.05426032,-0.027566629,-0.05333572,0.019584673,-0.025328817,0.0037915725,0.018205112,-0.062389787,-0.06417982,0.045698475,-0.059725992,-0.008601598,0.023142194,-0.042297333,0.020524774,0.016940273,-0.0043636146,0.012040016,-0.0015162072,-0.017684055,0.01941531,0.14311695,0.07016545,-2.2691845e-08,0.10964406,0.023024712,0.060938086,-0.024807926,0.006985728,-0.004590139,0.060682587,-0.021389265,0.03882755,0.0035106237,-0.06605822,0.039171115,0.02543349,-0.035985485,0.17940085,0.0046375063,-0.039406102,0.027693942,-0.082219385,-0.08784031,-0.018509129,-0.013470967,-0.12266719,0.11618886,-0.06915749,-0.0016037356,0.10554371,-0.0026547555,0.023194764,-0.06855788,0.006466895,-0.029755328,0.014113803,-0.045626678,0.002911993,0.08432407,0.04493099,-0.049339373,-0.008160443,0.047832303,-0.13514839,-0.052560247,-0.08818679,0.027047517,-0.013170566,0.023037637,-0.021177068,0.022964058,-0.043748792,-0.00045875242,0.0022272323,-0.023033824,-0.009740662,-0.053992532,0.029882474,-0.045450207,-0.034267906,-0.021818766,0.023348162,0.028371578,-0.03268506,0.00450293,0.106095925,-0.0518531 +3.6.1.45,"A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5'-nucleotidase (see EC 3.1.3.5) activity.",384,1.0,-0.014018667,-0.11230893,-0.020993894,-0.06214042,0.024980126,-0.0037402373,0.0055265264,0.056983795,-0.04424128,0.0059498153,-0.002975269,-0.0031185525,-0.1029194,0.09579535,-0.01514649,0.013462628,0.0046964106,-0.044054255,0.04101964,-0.009195271,0.08028023,-0.045532633,-0.00297341,0.0063844393,0.058369372,-0.028803091,0.050767682,-0.027129944,-0.01384535,-0.108541034,-0.054105923,-0.02425459,0.03949558,-0.060839366,0.037755158,0.10627519,-0.049693372,-0.044254493,-0.042189747,-0.034680147,0.08173804,-0.034306105,-0.031876206,0.00020186354,-0.03910129,-0.030090077,-0.027017308,0.013001119,0.012259227,-0.0016817253,-0.031401563,-0.06844725,0.016687654,0.016543506,0.0009485549,-0.008517864,-0.037318923,0.007167337,-0.02203402,0.015348246,-0.03397589,-0.0098049585,0.03171139,-0.045461807,0.08555453,-0.042653758,0.06157734,-0.07055005,-0.01687487,0.05111621,-0.042268883,-0.08087062,-0.05029469,0.03414101,-0.03882737,0.0048250104,0.020650163,-0.060993087,0.041427206,-0.03973024,-0.0386135,0.016700862,-0.035733894,0.055296075,0.045418285,-0.014641115,-0.017883856,0.014495668,0.020898566,0.018270211,-0.0010899494,0.0608712,-0.059444673,-0.041036084,-0.062862866,0.033380415,-0.03950838,0.01369629,0.0016672395,-0.044493414,0.03723155,0.10592164,-0.052875623,-0.02133053,-0.005898416,0.014038415,0.02313626,-0.023777733,0.0012670497,0.07047363,0.031130917,0.014930167,0.0069989637,-0.006803233,-0.011888773,0.022762509,-0.0435541,-0.08734388,-0.052107517,-0.0008886507,-0.028668862,-0.04803194,0.050445464,0.07255014,0.027003461,0.067961425,-0.04646958,1.2669122e-33,0.069149904,-0.022263382,-0.042071573,-0.0448518,-0.0108577525,0.016546901,-0.044202983,0.050272506,-0.020477254,0.022154406,-0.08197035,-0.059454247,0.11031229,0.060054034,-0.019826394,-0.024689483,0.032130636,0.029337736,0.025947524,0.01916873,-0.030307902,0.023579005,-0.021397628,0.05601703,0.082442865,0.053663127,-0.12890866,0.06330438,0.05273268,0.0006987405,0.044448383,-0.12488758,-0.08778965,0.011190292,0.07127024,-0.0066185044,-0.07562082,-0.032954585,0.0032113702,0.0014345887,0.03520089,0.010825063,0.07401541,-0.040884957,0.051136155,0.009056772,-0.023778819,0.060380947,-0.010774524,0.011728658,0.07131244,-0.06490809,0.12815486,-0.04321187,0.03719158,0.06408397,-0.021948354,0.01713236,0.030121243,0.10061225,-0.011865073,0.028699592,-0.06184715,-0.005815191,0.008897625,0.119576335,-0.07996839,-0.038263883,0.0405506,0.0040522492,0.011095535,0.00892564,0.026344988,0.0646547,0.00042687223,-0.003752995,0.011420801,-0.016100645,0.015182151,0.026293028,-0.005122077,-0.058080874,-0.018592237,-0.051160466,-0.09216856,0.012873276,0.043434802,-0.04264331,0.00533835,0.051930398,0.0068300334,-0.023775415,-0.061352406,0.002032202,-0.020471308,-3.3965094e-33,0.08792395,-0.0838203,0.003431635,-0.0772892,-0.033668183,0.05475645,0.070274115,-0.0816916,0.026128113,-0.03394842,0.032137424,-0.012231899,-0.0049496684,-0.038120568,-0.014942896,0.10077686,-0.10569733,0.07121658,0.044280153,-0.005866035,-0.057808265,0.15998729,0.03059713,0.09273528,0.09327556,-0.0012410398,-0.059996083,0.041569043,0.047267765,-0.029546624,-0.04258995,0.045123152,-0.0033880477,-0.091679916,-0.010252947,0.07299498,-0.012674847,-0.022301646,0.01985765,0.08914729,-0.034622446,0.11411046,0.033380236,0.054535303,-0.0066656256,0.053331405,-0.07985679,0.029742742,-0.08511033,-0.04910052,0.030634645,-0.030609423,0.008198215,0.041176867,0.038269393,0.075976446,0.015494919,0.02865692,-0.00046703173,-0.069121614,0.020633481,-0.08456946,-0.030834649,0.0069654845,-0.0026419314,0.12294286,-0.021764327,0.016088068,-0.053135004,-0.005976724,-0.029267022,-0.0032100766,0.035057962,-0.008922031,-0.11278082,-0.014491025,-0.028865993,0.048197325,0.05902589,-0.07117449,-0.037929274,0.07357038,-0.076036334,-0.06150402,-0.025438126,-0.01952517,0.026403978,0.017213294,0.03158129,0.02253796,-0.05661177,-0.03881565,-0.060545024,0.046111003,0.074607894,-4.5347814e-08,0.14381298,0.00041986443,0.04025689,-0.06359522,0.03588658,-0.00051162083,0.0018908267,0.014260954,0.065782025,0.05476111,-0.014529922,0.09423754,-0.017103925,-0.0069726915,0.0841064,-0.027271014,-0.020314332,0.0029499878,-0.07842496,0.005754045,-0.015075195,0.017041095,-0.16839692,0.03604601,-0.016042938,-0.03865784,0.05160605,-0.01643821,-0.0007991974,-0.049369294,0.007162219,0.05726528,0.022455825,-0.059035312,-0.015961882,0.074126676,-0.018017432,-0.059046585,-0.048207927,0.110029764,-0.06857683,-0.093988076,-0.050498355,-0.03833852,-0.0523571,0.016018055,-0.006216609,0.006081287,0.008371315,0.018792769,-0.03431989,-0.029911008,-0.060510453,-0.06276441,-0.032262184,-0.019326612,-0.046303578,-0.066075824,-0.04944804,-0.019449275,0.048770186,0.043014303,0.1631107,-0.08881094 +3.6.1.52,"This enzyme hydrolyses the diphosphate bond, leaving a phospho group where a diphospho group had been. It can also act on bis(adenosine) diphosphate.",384,1.0,-0.058034085,-0.020319782,-0.04013037,0.017791068,0.014821174,-0.00759197,0.03458341,0.008799747,0.039996974,0.020101504,0.038955607,0.015113571,-0.05317271,0.05219368,-0.035201825,0.06553672,-0.06873096,0.0018140587,-0.0010412816,-0.035963982,0.091240615,-0.003706184,-0.03335293,0.016407307,0.017395407,0.05370175,0.09486594,-0.007891873,0.03176656,-0.07460941,-0.055924263,0.020236962,0.05391946,-0.047031477,0.020233184,0.18437986,-0.029779652,-0.05841204,-0.009064109,0.0015950998,0.0980547,-0.006154649,0.00039477096,-0.03080526,-0.011358815,0.006213729,0.03175725,0.053959966,0.047549687,0.030148631,-0.016098067,-0.087834515,-0.03528545,0.04030123,-0.022568654,0.040965658,-0.10626053,0.049908474,-0.041896265,-0.00958416,0.0010446946,0.016825173,-0.014560331,0.06238826,0.074289344,-0.0425362,0.05678201,-0.024332074,0.037441205,-0.05335947,-0.015252444,-0.050275315,0.061788592,-0.025056146,0.03804206,0.024071274,0.006104015,-0.012590519,0.048073605,-0.049841262,0.018737393,-0.033470124,-0.008969866,0.01595823,0.023300571,0.041286048,0.022903772,-0.024512352,0.027193744,-0.018374594,-0.0020032148,0.011859998,-0.014443789,-0.07763297,-0.051091347,0.023744723,-0.011816548,0.014698764,-0.015047042,0.003951762,0.0667815,0.08929964,-0.068271816,-0.099148385,-0.0045533604,0.009027249,-0.035690784,0.009118089,0.011985437,0.0012408661,-0.058686383,0.025662744,0.08453638,-0.029559445,-0.050069194,0.06568643,-0.043030407,-0.046016462,-0.020513033,0.0036641443,0.006502515,-0.044893276,-0.04390208,0.113033876,-0.040891696,0.096374966,-0.111997195,1.1941588e-33,0.07175695,0.021968387,0.04443326,-0.04201983,-0.024976084,-0.029369697,-0.05607557,0.011181515,-0.12693813,-0.024256296,-0.0030179734,-0.07482302,0.091827944,0.0045575514,-0.018392107,-0.022995774,-0.013089498,0.016499832,0.09340856,0.028373946,-0.023634287,0.08747548,-0.09734064,0.009008981,-0.017796217,0.08575562,-0.09619014,0.018977929,0.054371532,-0.0021370905,0.060415365,-0.025524449,-0.1592604,0.013776351,0.005772029,-0.03664107,-0.0051141744,-0.08692983,-0.02122366,0.014989957,-0.030250566,-0.035005927,-0.01313298,-0.0036098994,0.061775137,-0.14189069,-0.05547024,0.022879124,0.10482122,0.057693437,0.038908526,-0.039358694,0.14099367,-0.011281392,-0.09127119,0.0033026875,-0.03406339,-0.042141095,0.014135699,0.030227456,0.012635671,0.02433466,-0.10827323,0.0057008807,-0.04772935,0.021240026,-0.022664892,-0.03311462,0.009239244,0.10348563,-0.071244046,0.0093914475,-0.037176576,0.048031054,-0.041497234,-0.011582253,-0.007232375,-0.010637338,-0.0029686263,0.05809761,0.059799623,-0.0876579,0.051576417,-0.029123023,-0.08575356,0.0036948617,0.07263083,-0.084349155,-0.038446233,0.046800133,0.014935061,-0.06722289,-0.036340173,0.022240672,0.03113686,-3.9440583e-33,0.108954914,-0.06934368,-0.026767736,-0.10730351,-0.06001576,-0.012955804,0.05641882,-0.053894244,0.011974246,-0.032123175,0.044463605,-0.06522242,0.083840884,-0.034027185,-0.03194622,0.09054786,-0.015558542,0.0215385,0.050304636,0.03167607,-0.010621583,0.11075266,0.120232254,0.10270579,0.03570001,-0.032913573,-0.0040247873,0.038353622,0.010057575,0.08849589,-0.04790109,-0.03174687,-0.04480735,-0.024319418,-0.04089927,0.037476726,-0.058337077,-0.0054492913,0.046016484,-0.036725536,0.017531455,0.009084834,0.06812708,0.07259159,0.040221468,0.097291216,-0.032817643,0.06928091,-0.09427875,-0.029043233,-0.011452906,0.05186526,0.025056724,0.042610813,0.048724085,0.03055603,-0.056378707,-0.009364535,-0.06433321,-0.03974517,-0.012933312,-0.10327004,-0.02972894,-0.04191744,0.06211379,0.06915027,-0.04618678,-0.022053815,-0.023586556,0.0032793153,0.046878304,0.021748422,0.0029810108,0.030198032,-0.027264925,0.0062919375,-0.08768024,-0.045109794,-0.012668209,-0.033886865,-0.015279159,0.04677463,0.0002043646,-0.058253307,-0.0012893634,-0.04264275,0.011164488,0.09714686,-0.008629646,0.0019197043,-0.030249912,-0.026739853,-0.0053510386,0.039780565,0.06236747,-3.080406e-08,0.038110048,-0.05820946,0.058067042,-0.080185525,0.015886605,0.005941937,0.030550525,-0.057259962,0.025838109,0.006296469,-0.07184786,0.052655563,0.008061982,-0.00087533734,0.087208115,0.003493349,-0.045275904,0.02199871,-0.02565284,-0.06538887,-0.051661134,-0.058301467,-0.08085052,0.07707694,0.02852732,0.009168,0.05257461,0.012389301,-0.046537165,-0.02178391,0.004040449,-0.02137254,-0.017813016,-0.017736683,0.0012331525,0.11895209,-0.046362378,0.035433922,-0.03709097,0.024253916,0.00035406635,-0.012645632,-0.051700413,0.016504752,-0.016056415,0.037733115,0.051132113,0.01053804,0.021570425,-0.0076953485,0.08084675,-0.05150115,-0.02962011,-0.0609868,-0.10960215,-0.07425068,-0.007593981,-0.018399742,0.02582601,-0.021425324,0.004480447,0.06534407,0.12827158,-0.060150094 +3.6.2.2,Requires Mn2+.,384,1.0,-0.036360487,-0.044458427,0.017822001,0.02654448,0.022565527,-0.07774763,-0.01671729,-0.0066741058,-0.08113136,0.008605609,0.037501145,-0.00853473,0.038291153,0.046258923,0.035204828,0.017164793,0.008483622,0.0010981181,0.022155419,0.043888234,0.09535097,-0.047738057,0.035636567,-0.10649236,0.080589876,0.038108997,0.021358317,-0.020172775,0.047707476,-0.022710444,0.001964823,0.07182767,0.03759382,-0.07103112,0.027451148,0.03208132,0.02418689,-0.031265844,-0.06567195,-0.0353328,-0.04206804,0.0073473584,0.111062475,-0.0032721923,0.010026853,-0.052635245,0.08713465,-0.06195826,0.032884475,0.050265517,-0.04517185,-0.010509251,-0.038998242,0.06577855,0.007258663,-0.013984565,-0.08798442,0.031221677,-0.020264747,0.020340305,-0.030886542,-0.06213404,-0.027272224,0.036563847,0.08422962,0.0193712,0.016521063,-0.05247887,-0.027940663,0.04684452,0.027259313,0.0340272,-0.06437856,0.02126383,-0.024103496,0.0154093485,0.071803205,-0.052876625,0.09380725,-0.0075167003,-0.11221875,-0.0030692108,0.02679672,-0.006094525,0.10713053,0.07699597,0.012755593,-0.016074155,-0.06754226,-0.0029608328,-0.0026667763,0.034529805,-0.0109483795,0.046426535,0.02924049,0.003930778,-0.03416443,0.031399682,-0.0929341,0.09565302,-0.01218027,0.035898115,-0.07906176,-0.0095144715,0.026446966,-0.07083552,0.06617603,0.040388364,-0.058188744,0.04259121,0.102053724,0.028116403,-0.0054726633,0.00010419161,0.023108644,0.028096316,0.024296738,-0.03508994,-0.00081681664,-0.0015044805,0.0229969,-0.01756427,-0.09027102,-0.007468594,-0.07151089,-0.034110405,0.0024530445,-2.1413545e-33,0.017724067,0.051661883,-0.021066902,0.043503698,-0.01049654,0.04684857,-0.049679115,-0.037014585,-0.004570793,-0.09597654,-0.09281623,-0.053237706,-0.020317584,0.0834843,0.04281833,-0.119611666,0.052882504,-0.017666025,0.14997219,-0.0137100015,0.020340055,0.0016038642,-0.02323011,-0.022663647,-0.013719981,0.07186442,0.13971443,-0.05194357,0.07355635,0.025671242,0.0034975566,-0.08866127,-0.06837138,0.0008731175,0.013852457,0.06542914,-0.11089267,-0.023947844,-0.010690566,-0.025923576,-0.023453522,0.08276505,-0.1598188,0.018604605,0.037131157,-0.077226475,0.0588696,0.04911015,-0.039315026,0.043499716,-0.028326973,0.057479832,-0.01836195,0.0353466,-0.021296928,0.016664,0.08537686,0.019563615,0.07890358,0.08904385,-0.05539112,-0.01854758,0.08613782,0.10673294,0.01158494,0.034094516,-0.04567807,-0.04347245,-0.030515159,0.024576593,0.012338733,-0.10936096,0.076678,0.050040204,-0.021210358,-0.018100826,-0.009838182,-0.05641133,0.025101343,0.02066164,-0.08478535,-0.03234737,0.0024155849,0.023543332,-0.028535549,-0.04999122,0.0005524045,-0.097215496,0.03474627,0.0019069682,0.040347915,-0.023461437,-0.007995815,-0.013179841,-0.066996664,2.4005619e-33,-0.0706518,0.002719601,-0.0036593815,-0.022310164,-0.05268765,0.012721533,-0.013786099,-0.14516166,-0.0033087102,0.04113643,0.04860708,0.026694657,0.0022195794,0.0088315625,0.028081888,-0.017074134,0.0328325,0.00096036313,0.09822324,0.0065470277,0.033520676,0.11440212,0.030622248,0.06478463,-0.02357111,0.10048431,-0.041434612,0.04047153,-0.025466217,0.0045668073,0.008560654,-0.019668229,-0.07769292,-0.060525987,-0.018999357,-0.023958255,0.04581214,-0.003129945,-0.052386582,-0.0062973793,0.05941968,-0.003584158,0.002867577,0.15827869,-0.036884867,-0.07479372,0.06889488,-0.027710633,-0.014873554,0.010659051,-0.02768638,-0.04464195,-0.032866392,-0.08967999,-0.01479311,-0.053243894,-0.0049085473,0.03820727,0.051891975,-0.02260523,0.033034775,-0.06314179,0.0043411446,-0.06140239,0.02199296,-0.009827642,0.053625256,0.020807983,0.008273043,0.06609688,0.03373152,0.09573834,0.13444178,-0.030186828,-0.05156394,-0.009566377,-0.046229932,0.06932179,0.057630423,-0.11416636,-0.031991832,-0.00066542113,0.026452256,-0.044617746,0.06507228,-0.11696032,0.07457187,0.022230344,-0.062330935,0.041871145,-0.031975985,-0.0023272657,0.0017889835,0.0713413,-0.03193887,-1.5502492e-08,-0.0412011,-0.054099,0.012802534,-0.039761156,-0.027760057,0.0279504,0.015556809,-0.014649026,0.063092485,0.053408284,0.07297596,0.011418391,0.016663948,0.0215658,0.047565706,0.0058561373,0.03988123,0.041688845,-0.10159479,-0.06914785,-0.05380872,-7.585195e-05,-0.016357306,0.07188331,0.028453324,0.04774252,0.015446269,0.079720974,0.055502303,0.0042644353,-0.03749378,0.027524283,0.0012584655,-0.04616325,-0.03520016,0.06888794,0.019522034,0.026726296,0.004062684,-0.06453956,-0.11053174,0.067457214,0.019091653,0.015239621,-0.02153527,-0.06587857,-0.072995566,-0.03542341,-0.039272733,-0.04022481,0.027580086,-0.04538773,0.004497423,-0.022909254,-0.016174618,0.05992906,-0.010969464,0.02129064,-0.016883198,0.010401383,0.069140926,-0.015784398,-0.0018027247,-0.06293484 +3.6.3.1,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme moves phospholipids such as phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine from one membrane face to the other ('flippase').",384,0.99999994,-0.059852734,-0.05218533,-0.016372802,-0.020240683,-0.0345491,-0.013465982,0.033915896,0.022684243,0.05667874,0.0038139077,0.012148225,0.018290224,-0.07603174,0.09134711,-0.014170667,-0.059671547,-0.06749398,0.03444917,0.104721196,-0.05344096,0.074290186,0.00010779156,0.0009800814,0.01940301,-0.055232987,0.079348214,0.027078178,-0.03231891,-0.03097161,-0.015826294,-0.12659748,-0.013359036,-0.031789824,-0.01613974,-0.01000834,0.12768295,-0.078970134,0.0609386,0.031872615,-0.025296865,0.1696986,-0.05267659,0.00644449,0.03377764,-0.048092104,-0.016078098,0.0035768163,0.03675954,-0.00039925406,-0.043882605,-0.012236265,-0.06302964,-0.09723859,0.011975572,-0.063502125,0.070208505,-0.014864217,0.023322428,-0.0071944282,-0.008555634,-0.039291456,0.01781835,0.011761095,0.075133316,0.08202255,-0.063990034,0.025086716,0.02253419,0.03402129,-0.04073249,-0.032475233,-0.022613559,-0.04194042,-0.007235826,0.014542691,-0.011006907,-0.04030936,0.047439754,0.003748188,-0.061200906,0.061904993,-0.04014911,-0.029931383,0.024771485,0.077824526,-0.00643962,-0.03558713,-0.0030095195,0.03021687,-0.010631038,-0.017788943,-0.051310293,-0.012193551,-0.0058453847,-0.08845533,-0.011291459,0.008399375,0.018669816,0.034086637,0.016186157,0.05762608,0.07724271,0.020481016,0.0076411986,0.0017919843,0.0036926602,-0.037705924,-0.05887559,-0.0056418898,0.055265933,-0.051032078,-8.469032e-05,0.0883089,-0.051432837,0.03723764,0.03836414,-0.06743944,0.0378141,0.0036985232,0.028472219,-0.07319825,-0.08404466,-0.009572702,0.009354373,-0.03412532,0.0483183,-0.050924994,5.303962e-33,-0.0066119875,-0.019619629,0.06578602,-0.013625939,-0.046139058,-0.004550451,-0.021594118,-0.052142452,-0.07353121,-0.06188739,-0.0113396,-0.03655426,0.012302358,0.05231546,-0.019702593,-0.043477405,-0.06846333,0.06940287,0.10420003,-0.06631768,0.0028909482,0.06438167,-0.02504124,0.03011392,0.050708346,0.017752528,-0.061498355,-0.010704309,0.032206513,-0.00096262107,0.03786712,-0.04966249,-0.09654727,-0.006592816,-0.013000175,-0.036124323,-0.089856125,-0.06433632,0.04651967,-0.06408937,-0.14464791,-0.0759383,-0.04072589,-0.030164247,0.009469857,-0.031056808,-0.059952024,0.06790176,-0.0076485607,0.042801134,0.04252555,-0.09738915,0.07317371,-0.018860964,-0.04298161,0.0006636066,0.037579395,-0.0030105636,-0.029915709,0.028934516,0.12682715,0.099165,-0.07506845,-0.03477089,0.008708229,0.08789858,-0.07863094,-0.099906325,0.0056524626,0.106334485,-0.057174347,0.038625866,-0.012558621,0.028884998,0.03873397,0.022778874,0.020405643,0.0051834327,-0.056149736,0.044692617,0.007976043,-0.051436912,0.05994566,0.0073411684,-0.028960759,-0.035333093,0.011149296,-0.069918595,0.0073525114,-0.013712928,0.083198294,-0.013036545,-0.011957201,0.12905684,0.040365968,-6.1585424e-33,0.042741563,-0.053126626,0.05717636,-0.091040544,-0.07526378,0.0031899968,0.038335063,0.014764557,0.04198343,0.01180592,-0.02857785,-0.015671775,-0.002407475,-0.037049852,0.0037902135,-0.030033538,0.0031301645,0.042964768,0.07031205,0.019494923,-0.011769985,0.12674122,0.009750825,0.08175657,-0.0004394243,-0.012504755,0.0102646705,0.07427218,0.011833306,0.019339783,-0.030489683,0.009081275,-0.021028075,-0.004696432,-0.08917627,0.006397986,0.00039296862,0.0045969146,-0.011646051,0.054141402,0.045273244,0.055842407,0.1260926,0.01388762,0.035249826,0.053624783,-0.0395128,0.05788077,-0.06839665,-0.044365577,-0.033537883,0.09732965,-0.07135223,0.041272383,0.06897436,0.08485655,0.025357243,0.014496218,-0.013108164,-0.10247928,-0.06653616,-0.13939351,0.011262374,0.039427105,0.0098454235,-0.0030442723,-0.01959787,-0.06982538,-0.022775907,0.057387065,0.055447116,0.10240133,-0.035380334,-0.012242782,0.024888396,-0.006278133,-0.0007302455,-0.013050963,-0.017766744,-0.019086007,-0.034400564,0.042374894,0.003413224,-0.046953168,-0.011412221,-0.05025047,-0.014112345,0.03058435,0.0347295,0.019515052,0.037065763,-0.02964529,0.0046591223,0.008758412,0.029964386,-3.7135717e-08,0.030164614,-0.021235047,0.099969,-0.0393537,0.024654394,0.022958664,0.05564629,-0.015765263,0.06802623,0.008917927,-0.040870972,0.050449546,0.06612277,-0.01569618,0.08570027,0.10102138,-0.07268309,0.051640414,-0.019489085,-0.085932456,0.013127412,-0.045611158,-0.09435814,0.12665732,0.05950147,-0.03312139,0.05173745,0.038299654,-0.075089835,-0.0512013,0.013277246,0.0013304597,0.022751015,-0.0294391,-0.043177146,0.046801157,-0.041632276,0.0021563252,-0.06256455,0.063734345,-0.04097571,-0.02296811,-0.03309381,0.008783875,0.03256903,0.07141519,0.06336498,0.0073710545,-0.0023962266,-0.023242112,0.037437722,-0.0061950916,-0.03040395,-0.11805528,-0.08806471,-0.00038399693,-0.03076027,-0.03893028,-0.0099726785,-0.02192221,0.043416686,0.006149798,0.17918612,-0.03604378 +3.6.3.2,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in both Gram-positive and Gram-negative bacteria, and three types are known, designated as CorA, MgtA and MgtB. The CorA itself is not an ATPase but an Mg2+ transporter.",384,0.99999994,-0.061813887,-0.067671485,0.032791108,-0.012218635,-0.017129049,0.011743808,0.039090622,0.049142517,0.04451782,-0.021823026,0.04335546,0.025705578,-0.044398673,0.113329545,-0.029890839,-0.0824588,-0.042255748,0.03871519,0.122838736,-0.011634117,0.09575094,0.06418077,-0.00924938,-0.0022251243,-0.026537126,0.00806455,0.046314195,-0.045838427,-0.017870856,-0.01948207,-0.14890671,-0.0207674,0.0050486205,0.0028370628,0.03755891,0.123036124,-0.060435742,0.027902715,0.06122733,-0.06469392,0.14926922,-0.012066928,0.0805318,0.0334182,-0.025594417,-0.026840942,0.04261663,-0.019700501,-0.035382487,-0.08833473,0.007817073,-0.021134544,-0.08286515,0.029535607,-0.027443629,0.0008338057,-0.028410414,-0.0005657464,-0.014096831,-0.052255683,-0.012758057,0.027681492,-0.011866703,-0.0055056694,0.08165559,0.011434548,0.05481529,0.024808818,0.02841884,-0.060912564,-0.024956571,-0.029068947,-0.053443603,0.011673763,-0.0444898,0.030667415,-0.021491984,0.0015637499,-0.028468998,0.00685463,0.02730686,-0.0051212907,-0.023150072,0.011366693,0.055149607,-0.007694875,-0.016399333,0.0045312517,0.013138611,0.007935719,-0.037647475,-0.00016662535,-0.012110786,-0.0029441556,-0.13509212,-0.014776873,-0.014356859,0.07318213,0.026815448,0.015975812,0.06269461,0.087720856,0.032185566,-0.011315724,-0.011964433,0.012374837,-0.013056965,-0.054507356,0.04914305,0.045773204,-0.055562142,0.017411454,0.0036491973,-0.07516199,0.008623086,0.07075773,-0.0905589,0.029111372,-0.01117182,0.05011289,-0.047109503,-0.09254152,0.016825099,-0.012724847,-0.010098395,0.04631077,-0.032792717,-7.72574e-34,-0.053999197,-0.04923435,0.119318075,-0.005148455,-0.021971313,0.007996496,-0.038967784,-0.050082467,-0.057259772,-0.11268769,-0.009327329,-0.030759623,-0.027195364,0.0031877307,-0.016160348,-0.031874705,-0.090175636,0.035732232,0.09451601,-0.015628297,0.020629233,0.07902254,-0.015566679,0.019910045,0.058674157,-0.010148268,0.016185673,-0.028891653,0.036524456,0.016357826,0.026273808,-0.07211033,-0.06817595,0.019289345,-0.02581002,-0.07452171,-0.109195136,-0.0260931,0.039871573,-0.06153034,-0.11142549,-0.035472047,-0.018763972,0.021847228,0.021593235,-0.04621335,-0.027207669,0.06094575,-0.042591427,0.04366898,0.07457293,-0.08797559,0.05617373,0.00899201,-0.03147959,0.03797341,0.020138599,0.06086178,0.016931333,0.03866491,0.15181991,0.09875355,0.0018841902,-0.052263353,-0.0021804033,0.07211019,-0.10928182,-0.10089629,0.07629856,0.08901464,-0.03946059,-0.010166491,-0.011238068,0.07566224,0.05476142,0.021158494,0.007814376,0.007559678,-0.013008372,-0.0040820683,-0.04671318,-0.056312054,0.053515628,0.025842153,-0.07073896,-0.04890897,-0.011155715,-0.036140945,0.00082823104,0.013189735,0.09404087,0.0492464,-0.045002792,0.09756449,0.03150667,1.396975e-34,0.06882172,-0.009576731,0.024766063,-0.11208945,-0.07395814,-0.014064667,0.06037573,-0.022948967,0.03565613,0.022305828,0.0032381755,-0.015955051,-0.022086889,-0.041970577,0.0030029675,-0.068753555,0.024009496,0.058319442,0.0133436965,0.03620849,-0.0067700036,0.10673085,0.03266983,0.02340764,-0.014221682,0.026919296,-0.0039721285,0.10962417,0.014151824,0.011044055,0.019558946,0.11237649,0.033754606,0.02167375,-0.12950015,-0.03117462,0.046840645,0.017755838,0.008304471,0.055586636,0.039692182,0.08335615,0.08873995,0.04033662,0.019393668,0.028844232,-0.0028025499,-0.00039664953,0.029102834,-0.035498485,-0.03491931,0.041685253,-0.062476534,-0.009030177,0.054076336,0.053002708,-0.007084374,0.014660873,-0.0045400523,-0.060478657,-0.059968363,-0.10770426,0.06719712,-0.019449268,0.018530574,-0.038694143,0.034650616,-0.07447959,-0.022431543,0.058435097,0.017664613,0.13522771,-0.05030209,-0.029546842,0.012958732,0.031968094,0.01061058,-0.0074173785,0.01034015,-0.09778624,-0.0726877,0.037471298,-0.034788746,-0.03430661,0.013381983,-0.07573429,-0.01560467,0.0417148,0.05851128,0.030327417,-0.01629662,-0.020890502,0.012251479,0.01677457,0.004113223,-3.027889e-08,0.025083428,-0.049228247,0.022528825,-0.020495463,0.011749252,0.018993543,-0.045799688,-0.04026855,0.12346624,0.0012565558,-0.0015601866,0.012618909,0.01959039,-0.05912437,0.06590987,0.051028814,-0.071706586,0.00408478,-0.05932381,-0.054020897,0.014450527,-0.058601737,-0.12477898,0.1245711,0.041778736,-0.027678138,0.024816222,0.0387148,-0.064862415,-0.057817016,0.01974995,0.017966771,0.015071222,-0.02967135,-0.05073847,0.05387321,-0.030390231,0.018237567,-0.04655131,0.031585824,-0.023010487,-0.06856549,-0.052572,0.023149937,0.060523048,0.07599225,0.0224112,0.029734088,-0.04489181,0.032484185,0.046284433,0.01360131,-0.049238753,-0.059010595,-0.090972625,0.03541308,0.008111166,-0.04274477,-0.03341472,-0.045728162,0.033286843,-0.026160842,0.1457921,-0.023235722 +3.6.3.3,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants.",384,0.99999994,-0.038827315,0.010527346,-0.0314211,-0.036208104,0.013588728,0.019046554,0.016918369,0.024929387,0.07413789,0.029788608,0.06415282,0.006394771,-0.07585273,0.11500084,-0.05178582,-0.06430541,-0.038233142,0.045798514,0.10159594,-0.051671103,0.099451736,0.07255003,0.0024910339,0.030915724,-0.0396579,0.0009051462,0.029109756,-0.029796218,-0.041149653,-0.034930754,-0.1511805,0.022338312,-0.010897528,0.0050487104,0.011387634,0.15417743,-0.06552311,0.018901737,0.054215916,-0.041226752,0.16616443,-0.06605225,0.007706685,0.037388634,-0.07144407,-0.0075225867,0.021830553,0.02566627,0.027501699,-0.06711641,-0.021555863,-0.055408757,-0.041356996,0.013282699,-0.054292113,0.02942222,0.0070098224,-0.0004543226,-0.0237808,-0.019855741,-0.029626276,0.00030070834,-0.0072641377,0.06228446,0.06749832,-0.043933783,0.046108175,0.04203154,0.006935688,-0.046260986,-0.038867712,-0.016066447,-0.030421535,-0.007052445,-0.017186692,0.027893735,-0.042760324,0.032536525,-0.018111173,-0.031726416,0.05958742,0.008404636,-0.035873145,-0.018982215,0.058251083,0.00870538,-0.0035699029,0.017361028,0.030982966,-0.029144691,-0.027613482,0.008547338,-0.0093933055,0.017847456,-0.12910466,0.044762522,0.06310263,0.0205942,0.064898826,-0.025167458,0.07358551,0.064035475,0.03784717,-0.0038079766,-0.01872156,0.017793791,-0.051810395,-0.031163355,0.015900576,0.06352409,-0.07266099,0.014712624,0.047190033,-0.05275022,0.035298765,0.05263533,-0.051651824,0.017798012,0.004153923,0.033388693,-0.061485924,-0.08004886,-0.019557323,-0.0051259687,-0.021942459,0.06006251,-0.06221396,-1.9655797e-33,-0.0009655202,0.002045216,0.048849136,-0.009977472,-0.0089313155,-0.01880935,-0.040284563,-0.061374463,-0.054245044,-0.14999723,-0.056108713,-0.053414173,-0.00840262,-0.004353076,-0.014466491,-0.024477249,-0.043175746,0.042123616,0.124572635,-0.0042714956,0.018647226,0.027829554,-0.057624076,0.04566036,0.037174884,0.028967531,-0.011901166,-0.022533065,0.040654134,-0.012138964,0.042391546,-0.06305077,-0.09120772,0.015476643,0.0034566324,-0.06304896,-0.055194903,-0.020612324,0.025856784,-0.062911585,-0.09980354,-0.06011099,-0.0030164716,-0.02114681,0.02261884,-0.061931882,-0.07001667,0.063590124,0.004293855,0.06515417,0.048201755,-0.07926815,0.11874598,-0.013682302,-0.065079935,-0.018263722,0.011408975,-0.019959142,-0.017839976,0.026698519,0.09446337,0.10544236,-0.029442031,0.011371418,-0.014874717,0.04261743,-0.115726404,-0.08867347,0.04562467,0.105508864,-0.06349363,-0.014066157,0.003912063,0.026303113,0.05137099,0.017261362,-0.012357556,-0.02721103,-0.050880644,0.06950322,-0.0223908,-0.06647134,0.02539137,0.025220864,-0.054809235,-0.02342425,0.0045120255,-0.030661538,-0.008883744,-0.023987694,0.10025331,0.0023490887,-0.010635027,0.08453553,0.053473562,-1.6898981e-34,0.15668294,-0.024290549,0.102537744,-0.063516185,-0.0493667,0.0032409828,-0.002293263,-0.007744713,0.008293802,-0.009914192,-0.03218647,-0.018024016,-0.0030398564,-0.035269033,-0.0024025668,-0.051407013,0.008793967,0.0798753,0.049523372,0.03573484,0.007651434,0.08882402,0.011387747,0.037076563,0.014128437,-0.044041764,0.00043337527,0.07533844,-0.036409836,-0.007305018,-0.010201909,0.03259494,-0.018795228,0.008255238,-0.0746201,0.011063751,0.009042939,-0.012671913,0.018079653,0.061869863,0.057996973,0.049731947,0.062066957,0.052219775,0.03321084,0.03423007,-0.022919755,0.032575503,-0.015320301,-0.026763653,-0.00032367694,0.098221205,-0.06625676,-0.009539585,0.07304807,0.05351221,0.029839536,0.04257565,-0.022429211,-0.059071753,-0.047444843,-0.10836601,-0.0067188484,0.031826567,-0.014773023,-0.0035423732,-0.013635406,-0.010688752,-0.005273275,0.069537796,0.049703322,0.12967259,-0.051570803,0.027797796,0.010886665,0.0095640365,-0.0019201039,-0.0137765,-0.02541287,-0.008020424,-0.046530083,0.047087103,-0.004800761,-0.06689257,-0.024370166,-0.10258649,-0.0003676096,0.0032607373,-0.013233443,0.017729051,0.01436039,-0.03669448,-0.016826602,0.020983113,0.020396788,-2.3517941e-08,0.022149827,-0.00035220452,0.073682696,-0.08975652,0.032038003,-0.0039974498,0.0496906,-0.010808308,0.119977735,0.0025103048,-0.039367046,0.024254803,0.085279144,0.0070742094,0.09795287,0.067741066,-0.036171094,0.0458239,-0.05021337,-0.040960263,0.006779689,-0.04194632,-0.16100168,0.121211275,0.055443257,-0.023030791,0.041961867,0.04579823,-0.048623268,-0.06264523,0.015201223,0.010259845,0.029053662,-0.04892178,-0.037671346,0.06777117,-0.048407406,-0.0011829844,-0.06849366,0.022212202,-0.030750047,-0.06318034,-0.042742766,-0.008272213,0.017625915,0.049399804,0.014507688,0.021853793,-0.020994272,-0.014829738,0.052914556,0.02525543,-0.030742848,-0.13139662,-0.102050096,-0.013343741,0.018130276,-0.053571057,-0.037794326,-0.06823024,0.053593576,0.0017136827,0.15758242,-0.058122598 +3.6.3.4,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme from the termophilic bacterium Archaeoglobus fulgidus is involved in copper extrusion from the cell [1,2].",384,1.0,-0.05876972,-0.022962295,0.0024577659,0.00950889,-0.02879187,-0.020410413,0.04113827,0.036064453,0.07130111,-0.003936073,0.025185239,-0.05685655,-0.0136280935,0.08116287,-0.06584394,-0.104698405,-0.048249435,0.028801972,0.08281878,-0.030624734,0.09983261,0.04900113,-0.0054615485,-0.028932588,-0.057297334,0.043843117,0.0051499093,-0.045485258,-0.04461839,-0.040001065,-0.10632626,0.0021781041,0.0029250267,0.029430358,0.073609434,0.1141341,-0.08115786,0.028184898,0.026897233,-0.07060162,0.124332026,-0.0053348206,0.056881618,0.054481883,-0.044995397,-0.0026082015,0.09526925,0.025354132,-0.0033701463,-0.030885177,-0.016623821,-0.02503597,-0.04720548,0.025673378,0.026887551,0.031744983,-0.006476933,-0.07040213,-0.031280402,-0.060207825,0.003630521,0.029749582,-0.03189536,0.060424667,0.03907872,-0.05554297,0.07849999,0.013887958,0.009854536,-0.015816553,-0.03231548,0.041982118,-0.04487305,-0.038161155,0.008360031,0.059985615,0.043396853,-0.01806022,0.027620329,-0.037612163,0.036182366,0.021291595,-0.021256477,-0.037752505,0.08910206,-0.0033868751,-0.0051507303,-0.015111887,-0.012875718,-0.05946398,0.014653399,-0.028884059,-0.040133324,-0.05111391,-0.08141203,0.0012187304,-0.016856756,0.014640395,0.03500732,-0.019526234,0.041265916,0.10315222,0.052261103,-0.054232355,-0.01504524,-0.035436675,-0.061283894,0.05539472,0.020041635,0.054675065,-0.075720385,-0.03297772,0.054556135,-0.027830798,0.034208007,0.041686185,-0.044504568,-0.02918556,-0.06977069,0.02675794,-0.072164536,-0.050956246,-0.021283979,0.042614475,-0.05710825,-0.012326816,-0.0315012,2.300714e-33,-0.01881179,-0.023937853,0.05570852,-0.016383361,0.0476388,-0.006477691,-0.02807131,-0.07568026,-0.04772722,-0.07446158,-0.0515402,-0.030676298,0.020240968,0.038240973,-0.046073012,-0.053281423,-0.09129566,0.063632995,0.10929211,-0.042175874,0.034877762,0.054328494,0.012793787,0.022848483,0.038904827,0.012452394,-0.02150333,-0.015968658,0.069705606,0.010149531,0.052027997,-0.07007231,-0.06974057,-0.014163429,0.02319549,-0.043175012,-0.05706861,-0.0108154025,0.033577193,-0.026693426,-0.07277937,-0.024008818,-0.031607617,0.026464166,0.0017651364,-0.050499696,-0.05374875,0.11361423,-0.0201093,0.06308877,0.08194916,-0.07748592,0.10726516,-0.02676638,-0.067521706,-0.0020911405,-0.017634038,-0.0031292073,-0.010894597,0.008419288,0.07442908,0.12782161,-0.036616918,0.010527262,-0.024003968,0.055315524,-0.050362416,-0.053348746,0.05718806,0.12778936,-0.0872532,0.018028801,-0.010271799,0.01761479,0.053305984,0.048636064,-0.045799214,-0.060671434,-0.038239725,0.056646682,-0.06873583,-0.060751744,0.027474936,0.00916941,-0.025851088,-0.057893068,0.0035121269,0.011542109,0.01439829,0.012483946,0.10082316,-0.01763527,-0.036588013,0.10790763,0.03546036,-3.2515162e-33,0.092191204,-0.046192084,0.0952484,-0.093327366,-0.037218414,-0.029625472,-0.0037296594,0.030283887,0.032922737,-0.019287853,0.021311697,0.01607014,0.021242857,0.0022685765,0.03214096,-0.06171515,-0.0008481252,0.080966085,0.003612626,0.045184594,-0.020752616,0.04104967,-0.011929639,-0.004163803,-0.007906222,0.030142728,-0.057640366,0.058737237,-0.004232845,-0.0023717657,-0.028641168,0.06692328,-0.033732317,-0.029082682,-0.10807585,0.0031629119,0.06275209,0.021069666,0.032932095,0.029871814,0.09436327,0.106443584,0.044209186,0.053879622,0.0263666,0.052422497,-0.034873456,-0.028875245,-0.03213006,0.004433783,-0.034271322,0.08635088,-0.06368338,0.0020005768,0.07910948,0.0782798,0.0038160663,0.0035743949,-0.05372125,-0.06627381,-0.0836439,-0.13084064,0.030435499,-0.0084148785,0.019352453,0.011509648,0.047562655,0.051089887,-0.020873154,0.017960422,0.05017201,0.11753873,-0.052724905,-0.0046566804,0.013518355,0.0098892525,-0.014812646,0.0032864858,0.011920954,0.013127953,-0.044770177,0.036615856,-0.01973948,-0.055542357,0.018630626,-0.11177029,0.018186292,0.0650837,-0.0019320117,-0.019582067,-0.033879023,-0.10612705,0.030202355,0.029024633,0.023406029,-3.2262545e-08,-0.024662213,0.021240268,0.065730266,-0.050735835,0.011411868,0.049261592,0.028643252,0.005955364,0.06746938,-0.043295637,0.027722806,0.05141062,0.053733606,-0.052827317,0.060293797,0.10767864,-0.08297814,-0.035251185,-0.011091279,-0.11290949,-0.018384673,-0.03976111,-0.09625588,0.13425733,0.02438158,-0.000957595,0.04616012,0.011128298,-0.12399113,-0.067360975,0.0016822326,0.03484344,-0.025455354,-0.005503802,-0.08039465,0.0041015954,-0.013848781,0.020176977,-0.06711024,0.073796734,-0.026206534,-0.035927705,-0.04157292,-0.008505869,0.03179388,0.0691598,0.02866809,0.047293168,-0.027545465,-0.027930103,0.03216895,0.05881509,-0.03937094,-0.06953583,-0.09298645,0.0061900388,-0.0227098,-0.03469396,-0.051434353,-0.0010338811,0.044687912,-0.023520239,0.16370155,-0.04029219 +3.6.3.5,A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme also exports Cd2+ and Pb2+.,384,1.0,-0.039492104,0.01645045,0.0006474731,-0.0093933055,-0.017402733,0.02436912,0.027128654,0.04499786,0.048090357,0.022006879,0.01830558,0.025422128,-0.044659607,0.05051522,-0.012274501,-0.07603242,-0.058088835,0.034733817,0.10385915,-0.07483912,0.10650595,0.023949109,0.0008158133,-0.0037695384,-0.069498114,0.024175933,0.05071261,-0.05139814,-0.018087687,-0.028062765,-0.11398356,-0.00330291,-0.03808708,0.005606009,0.036019545,0.12513618,-0.06357704,0.0318887,-0.0016955242,-0.08292669,0.15170746,-0.034118827,0.016583879,0.06732956,-0.07025721,-0.030893572,0.01709474,7.754038e-05,-0.013954404,-0.01909621,0.001404539,-0.017087748,-0.08253382,0.012665449,-0.0022556146,0.05432449,-0.062511355,0.02681097,-0.022566509,-0.025883092,-0.048209853,0.03283449,0.0045437543,0.06485148,0.07848711,-0.056701977,0.024892742,0.077994615,-0.02044392,-0.034526642,-0.039664734,-0.00051792146,-0.06181398,-0.032722604,0.0038239348,-0.033720918,-0.050008643,0.03405299,-0.0039130975,-0.040823396,0.03927425,-0.009441994,-0.004590633,0.0034773573,0.053606857,0.041489262,-0.010569792,-0.012113218,-0.0016755837,-0.017742356,-0.016677095,-0.028048491,0.00748778,0.014959974,-0.13111892,0.031049311,0.04755039,0.04468016,0.048917115,-0.0073239454,0.0645498,0.098299086,0.034938596,-0.025256969,-0.0074189636,-0.00088697346,-0.02747137,-0.024149755,0.03643455,0.05889443,-0.049244575,0.04812714,0.040687665,-0.08140591,0.034744635,0.06817883,-0.067194186,0.05252015,0.0074545527,0.00046157563,-0.03075936,-0.07092482,-0.0025963304,0.017837511,-0.048173968,0.026107088,-0.008005952,4.4241613e-34,-0.032150764,-0.04616617,0.079717256,-0.009175353,-0.056034315,-0.02827528,-0.03616808,-0.0802112,-0.069649406,-0.09602914,-0.04830092,-0.079111226,0.004879835,0.06312363,-0.01709213,-0.052398037,-0.07786691,0.05920766,0.15325512,-0.02085254,0.013706166,0.020005777,-0.016918529,0.08199276,0.062038563,0.030498406,0.000937837,0.015974635,0.056814123,0.009162765,0.022402052,-0.026826248,-0.066553585,-0.019866088,-0.035243314,-0.05326049,-0.08849481,0.00019375146,0.0479093,-0.044056863,-0.11252121,-0.06801907,-0.03220101,-0.032709077,0.0413604,-0.07807358,-0.027954727,0.034516938,-0.0043294793,0.057701293,0.026308859,-0.08905269,0.11835701,-0.008054754,-0.05428487,-0.0035912502,0.03012087,-0.018622061,-0.021835696,0.033880748,0.09392824,0.10775882,-0.016960476,-0.019359052,-0.03973202,0.08483733,-0.099989876,-0.106913954,0.02600732,0.08178659,-0.043201774,0.019619007,0.058915947,0.00413802,0.093919225,0.04240071,-0.01719565,-0.023075959,-0.03552802,0.06368013,-0.046444178,-0.06917261,-0.0032587564,0.042197935,-0.012103975,-0.074789464,-0.022711685,-0.060437318,0.015477892,0.023666995,0.087795705,-0.007215915,-0.05006866,0.10942178,0.04691851,-2.1537832e-33,0.10722,-0.021841379,0.094973736,-0.1003744,-0.038190357,-0.032179255,0.035496145,-0.033903036,0.008926511,0.004497132,-0.040350236,0.0009030059,-0.048237044,-0.037775405,-0.023067268,-0.048390925,-0.0048648803,0.09582423,0.020062745,0.037025232,0.04146275,0.088841185,0.040827774,0.054637562,0.0206904,0.0032244902,0.0028340595,0.09667392,0.018174045,-0.0036346246,-0.008789017,0.03627004,-0.006185703,-0.014595838,-0.11580654,-0.00598792,0.010961235,0.0035791711,-0.0163526,0.03139829,0.047070105,0.062824525,0.0698434,0.05253592,0.08084512,0.047421493,0.01814524,0.029058803,-0.019696193,-0.030336218,0.0010609394,0.06557263,-0.08067428,0.022711696,0.06752433,0.05141144,-0.009647847,0.02920158,0.007254553,-0.07937306,-0.0698931,-0.101773515,0.021613447,0.018470632,-0.033154137,-0.04277525,0.022320734,0.00063089735,-0.048803832,0.061292052,0.047153845,0.11245479,-0.025682049,0.011952307,0.030608619,-0.0102297375,-0.041168813,-0.03058926,-0.025592227,-0.00151631,-0.06622577,0.03818772,-0.022391327,-0.05698538,0.0014912823,-0.07296694,-0.009912686,-0.0064155567,0.0027699547,0.02859215,-0.031978536,-0.008137746,-0.032722246,0.043313853,-0.010201537,-2.6005186e-08,-0.005475842,-0.043925654,0.058978073,-0.07613314,0.015646541,0.02261013,0.020611076,0.01612448,0.07489346,-0.0032733968,-0.017830526,0.05995339,0.057607148,-0.029632924,0.081963904,0.104665965,-0.017669575,0.012756167,-0.0482362,-0.108732566,-0.012269461,-0.029972041,-0.07322427,0.13487998,0.038246103,-0.006121269,4.615594e-05,0.011602969,-0.03844658,-0.09912675,0.022177313,0.033475064,0.0129656615,-0.01237445,-0.029043073,0.04776724,-0.011966449,0.009847794,-0.022525702,0.04964809,-0.06383568,-0.051913925,-0.025714574,0.022962343,0.048885915,0.061103158,0.017173281,0.017000157,-0.052034464,-0.05151955,0.028498007,-0.00672657,-0.07052222,-0.11801581,-0.10219593,0.011466002,-0.06097353,-0.014439656,-0.0056094006,-0.062648505,0.035340283,0.006590988,0.15768392,-0.035319403 +3.6.3.6,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane.",384,1.0,-0.058729872,0.0027698176,-0.017528174,-0.0127034765,-0.0024736812,0.024063392,0.0463653,0.03354494,0.07454741,0.019190254,0.036320772,0.0031295584,-0.06412488,0.105788454,-0.044481356,-0.076858565,-0.030772625,0.03509405,0.09513454,-0.060336426,0.075365186,0.0408432,0.018871166,0.0071911938,-0.053292472,0.0074028275,0.035331987,-0.023344152,-0.048393928,-0.035458956,-0.13870697,-0.0040671946,-0.0053080125,-0.0039385827,-0.004009119,0.16690958,-0.07825739,0.034039095,0.042553212,-0.018093364,0.16100344,-0.048266906,0.004297524,0.038939804,-0.058852475,-0.025752729,0.0369315,-0.0024026204,0.011714932,-0.06456134,-0.012173275,-0.04788231,-0.040130574,-0.022885747,-0.060479246,0.029474897,0.0009651918,0.0016206277,-0.027128208,-0.04446374,-0.02772675,0.009152055,0.028813321,0.052803177,0.07323885,-0.06725589,0.063327976,0.051592562,0.025732895,-0.054354247,-0.03821835,-0.011230047,-0.042657267,-0.028043278,-0.020164713,0.004681741,-0.036572922,0.030584987,-0.015926152,-0.03387768,0.065518774,0.0040827403,-0.05484819,-0.01921763,0.06457407,0.0045931586,0.0031788612,-0.012901896,0.02281056,-0.014701971,-0.018500386,-0.02444516,-0.018122785,0.02137769,-0.1350521,0.03721773,0.048472755,-0.005626788,0.06295866,0.0058700405,0.06442895,0.08115112,0.029751457,0.0054531908,-0.008775809,0.0048066163,-0.045900963,-0.017826935,0.025959037,0.07496819,-0.06530689,-0.006488079,0.03193031,-0.054150123,0.034376297,0.066922136,-0.030815644,0.019348929,0.011592294,0.038957715,-0.04443912,-0.08384065,-0.043200366,0.008063931,-0.01783693,0.073262684,-0.03440973,-6.459717e-34,0.011713009,-0.03023277,0.06746951,-0.007122286,-0.010483943,-0.007480905,-0.028542817,-0.061375584,-0.07307475,-0.1306453,-0.050211567,-0.02613934,0.03216518,0.0102556,-0.0017830521,-0.02637504,-0.07864296,0.03679959,0.13538186,-0.0051211976,0.011535803,0.016679486,-0.038722854,0.05143122,0.04478223,0.026993293,-0.00055575406,-0.018637534,0.038211722,-0.013293743,0.029967306,-0.040229212,-0.08785399,0.02078607,-0.018283917,-0.041576073,-0.08007793,-0.023800401,0.068383425,-0.06751562,-0.10827558,-0.064071424,-0.001247159,-0.029799813,0.029624943,-0.049627528,-0.052474502,0.077691674,-0.0073350775,0.061094906,0.028486673,-0.07940693,0.12569647,-9.097991e-05,-0.056429084,-0.0058787125,0.0037088885,-0.0060921432,-0.013751244,0.027060114,0.11841274,0.11408611,-0.042385407,-0.006668603,-0.018223274,0.040576756,-0.10630948,-0.083453484,0.060883813,0.10960623,-0.06463499,-0.004504341,-0.012617762,0.014298612,0.03498435,0.035463274,-0.032437455,-0.01653654,-0.045857,0.06305608,-0.022977207,-0.060738567,0.050929397,0.030117374,-0.04052082,-0.04353373,-0.0044351546,-0.0287671,-0.0024835938,-0.028765604,0.07998698,0.017927798,-0.0021103742,0.0789504,0.03255623,-9.831133e-34,0.112373866,-0.022496229,0.06287552,-0.06687915,-0.037839636,0.0020637682,-0.0145783555,-0.00714166,-0.03234179,-0.002730806,-0.05511177,-0.0035566853,0.0015190745,-0.046813503,-0.0014415584,-0.062442355,-0.031262316,0.084477566,0.06292905,0.043701258,0.0153987855,0.09113694,0.02197402,0.05314777,0.025584606,-0.03826901,0.014097572,0.05488237,-0.03706777,0.018373538,-0.027147045,0.024697635,-0.029986363,0.021291977,-0.06660395,-0.002216975,0.016543435,-0.008802322,0.02764764,0.0744656,0.047792714,0.062492475,0.09326109,0.031108584,0.032072563,0.061528273,-0.03747166,0.032008905,-0.02738783,-0.037689578,-0.0044632056,0.101959884,-0.07111505,0.006979741,0.04377929,0.036441658,0.015999448,0.03043829,-0.009705056,-0.057442892,-0.06882507,-0.1158472,0.012329642,0.023949377,-0.020902572,-0.015393891,0.0009585495,-0.029870993,-0.001212636,0.051863335,0.072449125,0.120722,-0.029238954,0.0149217965,0.0064467266,0.009211221,-0.00020118635,-0.021778421,-0.022816906,-0.023445493,-0.017424865,0.03739142,-0.0073382645,-0.0719348,-0.012964081,-0.09542085,-0.0025106526,0.013007574,-0.010924503,0.018972937,0.02111768,-0.049050573,-0.022069907,0.021062119,0.007445254,-2.8263907e-08,0.035152256,0.011842049,0.07857355,-0.06032556,0.038537893,-0.0022037707,0.04382889,-0.021710245,0.10117041,0.0020896625,-0.020464044,0.0226792,0.07727969,-0.0019480481,0.11589842,0.094456695,-0.029915482,0.07393818,-0.051987275,-0.04380249,0.008286749,-0.031814106,-0.17895028,0.11159364,0.07516895,-0.021206792,0.049348533,0.027266935,-0.05292487,-0.080677114,0.009775065,0.013954977,0.0366644,-0.016638903,-0.027709542,0.062043637,-0.047834784,-0.012351325,-0.07211748,0.01501725,-0.056992695,-0.07152054,-0.037442196,-0.014627778,0.01679449,0.047907934,0.01781511,0.02098195,-0.019230504,0.01117561,0.057889573,0.016559353,-0.022419795,-0.1392527,-0.09825036,0.0031995145,0.00516793,-0.06513174,-0.03217773,-0.05578918,0.08189952,0.0010305903,0.15110134,-0.045482278 +3.6.3.7,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed.",384,0.99999994,-0.040280476,-0.01058873,0.034368798,-0.023304509,0.0009513128,0.020010144,0.05030362,-0.00044872743,0.04092312,0.025800759,0.028465524,0.014424156,-0.05832337,0.08979679,-0.050587803,-0.11247241,-0.06353718,0.041310173,0.073245265,-0.052610032,0.09546435,0.0463803,0.029106425,0.027988486,-0.02229682,-0.00029105583,0.043630708,-0.050592184,-0.007388806,-0.05350573,-0.13035537,-0.0014511412,-0.004031525,-0.0028006744,-0.0074833226,0.12271345,-0.06593816,0.06283894,0.012023027,-0.035434164,0.14084075,-0.032879245,0.034678772,0.06671116,-0.041886814,-0.02305557,0.01931783,-0.02732768,0.0060797133,-0.020850392,-0.015036547,-0.036470175,-0.06973465,-0.018089686,-0.0038326916,0.041940052,-0.057551533,-0.014725016,-0.0070911045,-0.019632656,-0.003991524,0.010318368,0.004405363,0.062601395,0.10635249,-0.05277687,0.065785944,0.056841962,0.007888165,-0.051484752,-0.046817947,-0.013865833,-0.039010637,-0.009346673,0.011874711,-0.00905027,-0.01993932,-0.005079862,-0.01549731,-0.0070028743,0.06264805,0.008337928,-0.008301391,-0.02428815,0.09813923,-0.023047317,0.0038758086,-0.015537785,0.03057636,-0.024433192,-0.0374044,-0.017052477,-0.0023857763,0.032642767,-0.085743226,0.0059893667,-0.006210959,0.043471158,0.017799698,0.01164967,0.08379689,0.1252775,0.062501654,0.00810861,0.00042336909,0.014951047,-0.010470277,-0.02843603,0.00041962016,0.09614768,-0.0354531,0.0017401961,0.03992944,-0.060302723,0.034023155,0.07320363,-0.041334376,0.0056702117,0.0018697032,-0.009575763,-0.03901983,-0.07779912,-0.016620534,0.0046361876,-0.03864182,0.04399623,-0.051199816,5.460236e-34,-0.042505626,-0.025816962,0.016749367,0.0057157115,-0.020012232,0.00822368,-0.07187681,-0.047938284,-0.07374027,-0.11249188,-0.030903516,0.003523394,0.0061202636,0.06574888,-0.050273255,-0.07281512,-0.03527713,0.054974705,0.12692977,-0.027615523,0.01695894,0.056956716,-0.03698006,0.05755957,0.047759164,0.033925645,-0.025911124,-0.004901298,0.025253192,-0.006123318,0.055354565,-0.06725432,-0.10079958,0.030962743,-0.03666182,-0.057025786,-0.057009295,-0.014617536,0.07302648,-0.045122325,-0.1401805,-0.04106224,-0.015117312,-0.009380176,-0.030307774,-0.058191262,-0.049575254,0.052150864,0.014883862,0.0652103,0.034121443,-0.07882287,0.07608073,-0.0098001035,-0.06648205,0.016583545,-0.007065416,0.0007064994,-0.023623353,0.039925274,0.08164898,0.12739548,-0.014489847,0.02386077,-0.03031162,0.03212987,-0.08595875,-0.124750935,0.09058572,0.079472706,-0.092350654,0.025998725,0.029941695,0.015689125,0.06111422,-0.0022011525,-0.035791725,-0.009889129,-0.05035959,0.064270616,-0.053579245,-0.09745303,0.022070607,0.048713256,-0.03642917,-0.03661941,-0.0016659241,-0.02056854,0.038241267,-0.024752526,0.059739664,-0.0018609638,-0.002748518,0.09338498,0.056975804,-1.9032995e-33,0.1306564,-0.040543698,0.07913371,-0.09316415,-0.06166444,0.012703378,0.07086365,-0.042484988,-0.04791155,-0.029440952,0.0006133609,-0.009798474,0.013401199,-0.038967278,0.0013950185,-0.06509868,0.00992963,0.06482519,0.043011937,0.032491907,0.025420524,0.09604701,-0.005092563,0.045803595,0.026765823,0.022302583,0.02474626,0.07825512,-0.0043120254,-0.0053521334,-0.030758893,0.034622263,-0.030827941,-0.019822348,-0.11916119,0.018577328,0.0077744727,0.04079596,-0.052340418,0.040371697,0.10543522,0.08209439,0.03084211,0.019337058,0.035473816,0.07213449,0.0053411247,0.040726848,0.0025998869,-0.06531695,0.031553224,0.08460587,-0.06323456,0.011065975,0.06839586,0.064394034,0.021538382,0.0032836904,-0.011364818,-0.0519862,-0.06473133,-0.095894255,0.036926474,-0.056376785,-0.008218304,-0.048219927,0.001202272,-0.04070762,-0.016887028,0.059670944,0.06966548,0.118722364,-0.01840262,0.00675301,0.017844856,0.0031785066,-0.022531256,-0.04233944,-0.0013397547,-0.059562713,-0.050689325,0.030568982,0.00029311312,-0.022876812,-0.00249868,-0.073724926,-0.013650445,0.011682182,0.028818417,0.006638825,0.012488383,-0.04284935,-0.06984999,0.04123923,-0.0176518,-2.7846816e-08,0.034232683,-0.02760311,0.03885627,-0.07741552,0.030239053,0.014011544,0.033986624,-0.016306879,0.07605576,0.0016503882,-0.013932237,0.050582066,0.058424015,0.013770563,0.07254231,0.0807209,-0.03436111,0.08039257,-0.05172032,-0.06814661,-0.019776948,-0.018866781,-0.15092255,0.12478672,0.029337559,-0.01531852,0.05257219,0.030892162,-0.04172279,-0.12285574,-0.0044645886,0.0380339,0.029517317,-0.021285746,-0.04050682,0.059545472,-0.02082958,0.0075879693,-0.064555556,0.028571554,-0.077234685,-0.05268458,-0.02271673,0.004463121,0.0011028182,0.0356825,0.015483001,0.0059737763,-0.018180482,-0.008100781,0.053735584,0.018446315,-0.044271518,-0.08656157,-0.09936522,-0.012202154,-0.04025054,-0.07500938,-0.021080123,-0.030103069,0.07047004,-0.050810035,0.12889288,-0.07093246 +3.6.3.8,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme family comprises three types of Ca2+-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in yeast. The first and third transport one ion per ATP hydrolysed, whereas the second transports two ions. Ca2+ is transported from the cytosol [side 1] into the sarcoplasmic reticulum in muscle cells [side 2].",384,1.0,-0.016886774,-0.037163716,0.006082991,-0.020600244,-0.054765757,0.0256283,0.06372009,0.03261284,0.091876574,0.00550823,0.013381611,0.016562294,-0.059655722,0.12935627,-0.046689484,-0.12680602,-0.069412746,0.05213494,0.08819144,-0.04547482,0.104388155,0.00019967502,0.0056819557,0.009204419,-0.00044367494,0.01543334,0.005115373,-0.03193967,-0.015531665,-0.010127601,-0.14576854,-0.01001591,-0.05681257,-0.0027759434,0.024581322,0.14353086,-0.04967428,0.03202033,-0.020569844,-0.037279516,0.13608605,-0.020222208,0.021999894,0.05326838,-0.029478699,-0.009234401,0.030297587,-0.0350137,0.005698007,-0.04474891,-0.049714383,-0.033435334,-0.08992096,0.057474867,-0.020254696,0.063724466,-0.05720398,0.032982256,0.015112656,-0.011041382,-0.026806114,0.003948565,0.030011883,0.040500935,0.08193666,-0.044303976,0.026636489,0.02641862,0.022039898,-0.028048143,-0.045028694,-0.005824599,-0.05743857,-0.024911184,-0.013548276,-0.031750664,-0.031311892,0.022281142,-0.0002651889,-0.06989309,0.079249434,-0.0324732,-0.03624262,0.0075606722,0.061542917,0.031979796,0.01538711,-0.026983978,0.04933616,-0.022024432,0.008055404,-0.003518814,0.0064336103,0.00036174624,-0.068572074,-0.0019559406,0.018368457,0.059224904,0.05799986,-0.030802734,0.11393001,0.086706124,0.07882086,-0.0032375976,0.00978062,0.036159687,-0.04613436,-0.023696324,-0.022537261,0.072326474,-0.03178676,0.04327405,0.014544672,-0.060603403,0.05547231,0.12875706,-0.055503,0.012173455,-0.0030745494,0.014913515,-0.068205036,-0.11014314,-0.006970642,-0.018888969,-0.015151655,0.028762752,-0.07187897,2.6727382e-33,-0.033653934,-0.0004676519,0.050966933,-0.010102576,-0.021075945,-0.026548523,-0.022971904,-0.037980024,-0.06592161,-0.10304115,-0.013413156,-0.0032087122,-0.02598628,0.08458536,0.016451836,-0.034805868,-0.0496146,0.022227122,0.10934673,-0.021685839,0.029164566,0.074521445,0.0068089818,0.05203588,0.10905996,-0.0029393185,-0.04231046,0.024064152,0.022154735,-0.0053737047,0.048827443,-0.084201716,-0.09144334,0.02362718,0.0037522274,-0.013743072,-0.057833504,0.020154081,0.055736512,-0.027520448,-0.07234587,-0.05449508,-0.0025231312,-0.026107717,0.0046789683,-0.09271221,-0.055127867,0.03431066,0.003468097,0.050466683,0.020477979,-0.06524692,0.08434033,-0.026051428,-0.04936313,0.0017591959,0.008061486,0.019930635,-0.059464112,0.038669817,0.1006416,0.07404465,-0.017785255,0.018743051,-0.012546748,0.056538988,-0.101772174,-0.07752712,0.033598818,0.090111986,-0.08102726,0.021162234,0.029761204,0.010127844,0.07484539,-0.0098597165,-0.043448787,0.0077468073,-0.06828364,0.033626672,-0.04581637,-0.059099346,0.04835176,0.083552614,-0.052912753,-0.034576487,0.032753218,-0.058295224,0.017341262,0.011711564,0.06327163,0.04035152,0.017942157,0.106516846,0.0034849192,-3.5335202e-33,0.10475031,-0.020911247,0.11302166,-0.10461543,-0.08726085,0.03187658,0.030531606,-0.026131764,0.0150317075,-0.0026122138,-0.02034094,-0.0051012575,-0.0039516445,-0.058136757,-0.006022861,-0.042836595,-0.017712507,0.0892478,0.031596128,0.0009530338,0.03775075,0.09044244,0.028698834,0.06626316,0.004752242,-0.0131327,0.02216174,0.052054435,-0.014337215,-0.016246222,-0.05276915,-0.010562376,-0.026389375,0.0048023923,-0.118335016,-0.021404343,0.019284012,0.0355159,-0.0138766,0.086636275,0.059375744,0.050013494,0.044666443,0.042781804,0.017387124,0.022713263,0.024501026,0.028282836,-0.036653478,-0.037103225,-0.0017444886,0.01951222,-0.090497315,0.021564651,0.07108062,0.06943979,0.03792949,0.042772673,-0.041265022,-0.060056347,-0.077892855,-0.10893624,0.01451504,-0.040476803,0.034581777,-0.03322118,-0.017276635,-0.069062866,-0.032765027,0.038267426,0.052610412,0.07199343,-0.04207746,0.006385814,-0.0012360406,0.016697068,-0.0142979855,-0.03258732,-0.016582923,-0.044914175,-0.023347126,0.04447816,-0.0021778834,-0.04754873,0.012449396,-0.03577983,0.008285504,0.011940538,0.0012717369,0.003937011,0.025795978,-0.035137966,-0.0005670887,0.01829419,0.020432197,-3.7479886e-08,0.040417597,-0.012805251,0.007020941,-0.06142083,0.014797627,0.026009379,0.024680736,0.027977396,0.059277836,0.023634298,-0.06816596,0.039018583,0.05016332,0.0080405595,0.03974432,0.098878056,-0.07807816,0.04111546,-0.04313658,-0.09786448,-0.004009551,-0.045999344,-0.1258925,0.14177252,0.029896086,-0.011020935,0.026490932,0.02564336,-0.06408875,-0.041303508,-0.017962422,0.010864545,0.01996142,-0.05107656,-0.033782125,0.009731165,-0.012151512,0.0022594556,-0.094770245,0.055060834,-0.0068695364,-0.07531956,-0.029449891,0.026811702,0.06416629,0.04296266,0.009193603,0.011307756,0.0054006195,0.019323822,0.05964557,0.01038605,-0.04072408,-0.15536089,-0.118551895,0.041018497,-0.033649735,-0.053325728,-0.006174154,-0.041658904,0.07345174,-0.003906566,0.14554873,-0.062227067 +3.6.3.9,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.",384,0.99999994,-0.043924566,-0.0022027162,0.012537781,-0.015506897,-0.048177022,0.023783725,0.07430067,-0.002615741,0.07290095,0.023379495,-0.018291572,0.012566865,-0.04988916,0.1161501,-0.030626222,-0.09771239,-0.042809043,0.034560632,0.0788574,-0.058757335,0.08036656,-0.0029776837,-0.0005830468,-0.0075377277,-0.046982754,0.035866804,0.044848546,-0.04261926,-0.031465843,-0.0034877937,-0.14880522,-0.03626263,-0.016828068,0.015499004,-0.0031775318,0.11852509,-0.120616496,0.06811813,-0.010443999,-0.010626777,0.15445964,-0.041267388,0.035100605,0.016515184,-0.036560737,-0.030523568,-0.0031145655,-0.027447691,0.007585358,-0.040377762,-0.0007580922,-0.021154784,-0.06849793,-0.014472588,-0.024222465,0.007364565,-0.06060207,0.0119692525,-0.0061294334,-0.035947897,-0.010990367,0.021242676,0.031870436,0.06515254,0.119612366,-0.073383674,0.055284865,0.04460037,0.021845024,-0.054903448,-0.02923914,-0.018145619,-0.0061344425,-0.026636349,0.008072478,-0.044487808,-0.050632175,0.026862826,-0.013770725,-0.011666741,0.08170823,-0.009196198,-0.04963292,0.002378412,0.093147755,0.015229888,-0.018496664,-0.022916524,0.002475228,-0.018633468,-0.017396169,-0.047217086,-0.012372754,0.024689535,-0.11309868,0.0061055496,0.0061088856,0.021785768,0.04489756,0.017447887,0.06471176,0.10456367,0.050545394,-0.009040148,0.0065736,0.0046394328,-0.015393191,-0.009278516,0.009417746,0.09061995,-0.073848195,0.004414958,0.016945077,-0.04048158,0.05053415,0.09904478,-0.04207506,8.075991e-05,0.01680373,0.04232587,-0.03449148,-0.105172254,-0.03186611,0.028871339,-0.020799397,0.0653918,-0.035203148,7.132565e-34,-0.03953169,-0.032470893,0.057041623,-0.012853814,-0.013485494,-0.00032722068,-0.041042805,-0.06094937,-0.06170979,-0.11288934,-0.010337014,-0.0030027826,0.056461923,0.04539074,-0.026010027,-0.047864202,-0.07621178,0.035163943,0.12564377,-0.01591407,0.0408982,0.030807734,0.0010005772,0.065735064,0.022293188,0.0024113408,-0.048653807,0.009361912,0.03397766,0.010635778,0.04422089,-0.06110827,-0.07444376,0.0052985325,-0.077307634,-0.06350656,-0.10815099,-0.04749706,0.08839119,-0.046229012,-0.1455799,-0.07591787,-0.009337524,-0.0034562936,-0.0016633708,-0.045509975,-0.053538322,0.08135882,-0.015965011,0.043326356,0.052727215,-0.07634844,0.087507196,-0.03570278,-0.04794364,0.027916247,0.0038511325,-0.00582502,-0.015947413,0.032347497,0.130498,0.09709782,-0.03264793,0.005352054,-0.016754646,0.05245378,-0.07184703,-0.082706586,0.07721393,0.07993838,-0.07695,0.023478772,0.017123364,0.005818329,0.053040117,0.01934098,0.026927458,0.013244402,-0.054088075,0.039413527,-0.018507686,-0.061912753,0.06558762,0.058724,-0.024648229,-0.05455094,-0.0043030884,-0.035303306,0.013092468,-0.012205594,0.080764376,0.017281022,-0.0447973,0.075499326,0.03876653,-2.3178238e-33,0.10973392,-0.026152324,0.045910034,-0.09958163,-0.033780757,0.0066755405,0.044403933,-0.025339328,-0.015066705,-0.0005629573,-0.015857778,0.008314569,0.02091809,-0.038329646,-0.017108383,-0.054946724,-0.017545937,0.04547537,0.05340234,0.0069987527,0.016836343,0.07073586,0.026414128,0.04392764,-0.013014697,-0.0077989236,-0.012148867,0.046141572,-0.010684407,0.01820958,-0.033443175,0.021218542,-0.04014963,0.004969587,-0.08089034,0.00010701886,0.045734994,0.013454302,-0.0069455965,0.035279118,0.054784693,0.07449803,0.07519476,-0.02051989,0.039842714,0.095318675,0.027833063,0.025841754,-0.015823765,-0.07228155,0.007705396,0.09015689,-0.07144182,0.026843345,0.026883697,0.070785455,0.016432729,0.012909503,0.011141287,-0.066501565,-0.08385865,-0.11674106,0.05957536,0.00091062795,-0.020177355,-0.0579123,0.0039629424,-0.042226132,-0.026747825,0.053258955,0.060265988,0.118088685,-0.05118918,0.013565894,0.008132405,0.012353499,0.004601717,-0.020588247,-0.007223152,-0.034336224,-0.021734929,0.04332915,-0.031369634,-0.049009845,0.0040998864,-0.06899153,0.0051441053,0.040236346,0.034009043,0.00042591654,0.028247567,-0.047120273,-0.058136452,0.025188541,0.0026418064,-3.330299e-08,0.028300643,-0.026366886,0.037522733,-0.06069269,0.032415174,0.015021345,0.027416177,-0.035416424,0.08489721,-0.02285323,0.00084514334,0.02621046,0.059461042,-0.007801612,0.06919381,0.074560694,-0.05067394,0.056079954,-0.036398217,-0.068462744,-0.0021849682,-0.037042804,-0.14795291,0.10983839,0.07657889,-0.0022716443,0.039073084,0.009643917,-0.067925245,-0.10444732,-0.007421932,0.01039856,0.032236308,-0.01937399,-0.047110405,0.06479252,-0.021566927,0.0088275755,-0.067640565,0.023037102,-0.049566727,-0.07744418,-0.010530995,-0.005909447,0.032524522,0.07278479,0.012579689,0.0034821336,-0.029445913,0.0095129935,0.022019895,0.013962678,-0.0547424,-0.11908361,-0.08249724,-0.00022401765,-0.038523898,-0.08346627,-0.003539336,-0.054504402,0.098628975,0.011095296,0.1442251,-0.03049599 +3.6.3.10,A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed.,384,1.0,0.0046793474,-0.0020911065,-0.00094679557,-0.012086233,-0.035022873,0.0076015517,0.057661,0.004252646,0.07551895,-0.022179747,0.013871726,0.026753603,-0.051507294,0.09594511,-0.018018112,-0.080392495,-0.0625964,0.025715461,0.09129026,-0.0775828,0.07030937,0.0035221544,0.025053715,0.026512763,-0.05463891,0.01406638,0.080483325,-0.0283255,-0.019212982,0.023366312,-0.13360247,-0.03393647,0.011543338,0.019527204,0.036980286,0.106580615,-0.053337343,0.054992847,0.010048771,0.00032342333,0.12520488,-0.055478074,-0.002986679,0.040475186,-0.060469456,-0.036219843,0.018766899,0.030897425,-0.04250415,-0.048946917,-0.018966177,-0.039546747,-0.10668635,-0.020252818,-0.0038751948,0.024616394,-0.06702648,-0.0027656,-0.008611747,-0.07392797,-0.023979219,0.020171834,0.011973829,0.06460049,0.0722889,-0.08449921,0.0690311,0.038036812,0.034649707,-0.023525875,-0.07031595,-0.044369083,-0.053597078,-0.008811406,-0.0110094845,-0.019515434,-0.0623978,0.01934446,0.00083715154,-0.021069184,0.08782834,-0.0037429517,-0.04011929,-0.034923155,0.0781916,0.017270796,-0.018009432,0.014168464,0.026926754,-0.06417581,-0.05212572,-0.0917833,-0.008188109,-0.004967768,-0.07902456,-0.0013774516,0.006538717,0.014393198,0.04842886,0.011768695,0.026232928,0.091320865,0.06481407,0.02299311,-0.0180051,0.018489422,-0.015814684,-0.008077429,0.046813607,0.053746928,-0.0804137,0.008276089,0.045115616,-0.04013967,0.03243192,0.08345109,-0.04150741,0.027403818,-0.0050164135,0.046816863,-0.05351383,-0.06862428,-0.02391365,0.032276046,-0.04124501,0.032464,-0.051946376,2.0063417e-33,-0.027756123,-0.02992829,0.08169763,-0.028449211,-0.016206594,-0.005300803,-0.032550927,-0.07433973,-0.042268686,-0.067571945,-0.020597516,-0.033820093,0.033290517,0.048400603,-0.03637449,-0.05331851,-0.07300464,0.078880586,0.113856584,-0.022806026,-0.008248187,0.04661751,-0.019288823,0.03139651,0.029794056,0.037073378,-0.051146936,0.01955424,0.056230165,-0.0035239388,0.03437776,-0.06141842,-0.052598838,0.0053807143,-0.07045739,-0.08496109,-0.099077284,-0.019774282,0.08525943,-0.0626404,-0.15838249,-0.08600318,-0.025122035,-0.033972964,-0.015160409,-0.049751986,-0.047808874,0.085348904,-0.0051439684,0.045357324,0.06299595,-0.082371116,0.0889172,-0.04254426,-0.07119728,0.0009002757,0.021531956,0.005748413,-0.018195024,0.018687777,0.09538987,0.1149192,-0.019018486,-0.002449388,-0.02174106,0.04729353,-0.11520722,-0.07700048,0.06352664,0.10878818,-0.0962734,0.052672442,0.005382094,0.0032395907,0.066931784,-0.017634736,0.02444298,0.008089774,-0.070436865,0.06484189,-0.03466697,-0.0775595,0.07017393,0.05043838,-0.03642875,-0.032770306,-0.03752594,-0.05538005,0.037867125,0.05420607,0.011016984,0.020848475,-0.012291623,0.13073839,0.08853448,-3.316762e-33,0.08679697,-0.030329717,0.042204574,-0.08425426,-0.031910013,0.022628201,0.033070765,-0.040328126,-0.036191396,-0.03588945,-0.020783763,0.019681137,0.0010950448,-0.05462177,0.015539192,-0.019011965,0.01927234,0.05278308,0.05114557,0.034148388,0.038880423,0.0711805,-0.014685826,0.008929775,-0.009590149,0.014364307,0.026856724,0.05588806,0.024855904,0.002104972,-0.0076055727,0.010770325,-0.027741518,-0.01528945,-0.080992304,-0.008234533,0.03785419,0.047309477,-0.011736857,0.039729264,0.0517252,0.07839519,0.088685244,0.036821064,0.03918972,0.06071002,0.037693437,-0.02227229,-0.02941943,-0.07211708,-0.0077904826,0.08376179,-0.08396297,0.029400492,0.06387265,0.08892436,0.0071958792,0.0027949607,0.004672685,-0.08571455,-0.10164879,-0.12530518,0.039372414,0.052512646,-0.004060002,-0.05274816,-0.010234319,-0.054365315,-0.030168507,0.057544198,0.057153784,0.09952737,-0.044423923,0.020533431,0.0383529,0.0045389733,-0.008941543,-0.023027452,-0.028850155,-0.026875362,-0.05416554,0.025209337,-0.04111527,-0.07685698,-0.005178793,-0.06885012,-0.023392132,0.023062635,0.03210438,0.011422337,0.026014015,-0.02954922,-0.016630985,-0.009815917,0.02620726,-3.0785056e-08,0.006946951,-0.052224956,0.034975916,-0.02332108,0.031124875,0.026862541,0.025392834,-0.0013864178,0.07799718,-0.03068424,0.010850952,0.0113581875,0.08818044,-0.010175582,0.054783586,0.05715675,-0.07084336,0.040105667,-0.019322623,-0.056996476,-0.025098044,-0.026643625,-0.10150282,0.1187923,0.06804014,-0.016707983,0.038539283,0.045423917,-0.07271354,-0.084705,0.034691714,0.036961794,0.016716382,0.018332904,-0.044748027,0.019248141,-0.029935433,0.05060191,-0.07349923,0.041030522,-0.023113219,-0.04170092,-0.017633425,0.013841782,0.04877144,0.07938807,-0.0007274571,0.006901874,-0.017099027,0.0014965136,0.043946527,0.020933108,-0.055799577,-0.10401534,-0.057958286,-0.0085262945,-0.008272854,-0.060965247,-0.008002135,-0.050943516,0.071892366,0.008138407,0.14557299,-0.050702993 +3.6.3.11,A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. An animal and plant enzyme involved in the import of chloride anions.,384,1.0,-0.063081816,-0.018503381,0.012460579,-0.0064069033,-0.0415187,0.037885725,0.0892803,0.0029801468,0.099459164,0.014631612,0.03688138,-0.009196482,-0.02107049,0.10676972,-0.072467566,-0.078996904,-0.050740473,0.04588876,0.06654837,-0.07879605,0.074307285,0.04167089,-0.02883244,0.016037641,-0.05085472,0.014323361,0.011679631,-0.07660797,-0.030530563,-0.025366962,-0.16338609,0.020041844,0.05083293,0.010909673,0.027157623,0.15376766,-0.061589234,0.008521266,0.013155268,-0.032280177,0.1404969,-0.03434174,0.01923545,0.050843973,-0.05651224,-0.006971725,0.024120929,-0.016079558,-0.007956265,-0.04775124,0.0076829493,-0.025904534,-0.08281022,-0.039819553,-0.07059209,0.033039197,-0.025708325,0.03409639,-0.034763433,-0.02519348,-0.011683938,0.03792892,-0.011104672,0.07682586,0.072863534,-0.065275624,0.057440292,0.04333981,-0.0077912896,-0.07680905,-0.045782197,-0.028368862,-0.008509624,-0.03385947,0.01877872,-0.021207409,-0.032319043,0.0073244367,-0.024685005,-0.04415864,0.040828537,-0.012877499,-0.026846273,0.0020096002,0.070643656,-0.021635326,-0.0063119596,-0.013001954,0.013232633,-0.033864032,-0.019287784,-0.047251597,-0.023109995,-0.0049201106,-0.08714283,0.058216307,0.018976381,0.008910454,0.037073355,-0.010634596,0.054966714,0.1370726,0.04408345,-0.01265583,0.010572563,0.028722849,-0.06795626,-0.022026658,0.054680023,0.07303497,-0.075749785,0.028757455,0.06333551,-0.040262148,0.03172406,0.11152273,-0.07433002,-0.005642763,0.008940933,0.026436167,-0.06508667,-0.08335711,-0.04001625,0.07553702,-0.00648884,0.055111036,-0.052322216,-1.7262669e-33,-0.0256281,-0.029428273,0.0763006,0.042070918,-0.0877062,-0.04269982,-0.025804773,-0.06388872,-0.04566605,-0.13718675,-0.034368694,-0.043930758,0.007544405,0.00043254116,-0.004246753,-0.045112137,-0.03236988,0.026672602,0.15719791,-0.03105007,-0.026846737,0.036211174,-0.0059777224,0.061783627,0.07443301,0.0018371667,-0.03957665,-0.02500035,0.07307553,-0.0023705312,0.043546405,-0.046041835,-0.09122279,0.03990315,-0.030316828,-0.053167302,-0.07061313,-0.00067059,0.04003662,-0.030189646,-0.10466823,-0.05671142,-8.173951e-05,-0.0022145715,0.033139452,-0.028992606,-0.06563093,0.06656679,-0.008709164,0.08165786,0.02646817,-0.056744803,0.08497754,-0.061186146,-0.09923372,0.009573826,0.032724146,0.0009226262,-0.046929114,0.06954151,0.10706495,0.13167867,-0.03517643,0.012589087,0.017327975,0.051199745,-0.094512306,-0.105152495,0.053013634,0.08619811,-0.09171477,0.004175809,0.04078672,0.01246541,0.040497627,0.015731925,0.017491465,-0.0155636035,-0.037933838,0.017399855,-0.011174048,-0.06371769,0.05874566,0.05413483,-0.05736596,-0.059995018,0.01324445,-0.032000944,0.030295344,-0.036142267,0.12949544,0.017741615,-0.039526165,0.042435948,0.07303194,-1.6550687e-34,0.13001877,-0.019573875,0.04983544,-0.06521363,-0.062184874,-0.006117884,0.02881065,-0.019243767,0.007863139,-0.0031967536,-0.027869688,0.015436809,-0.007662962,-0.05920712,-0.023620248,-0.0304837,0.049494192,0.09708181,0.015445956,0.055637155,-0.020053433,0.079466745,0.037598222,0.028484344,-0.036516443,0.00690231,-0.022625936,0.027696371,0.009419247,0.005350274,0.002706558,0.018590039,-0.01369735,-0.045951113,-0.07939571,-0.0263292,0.018952513,-0.015871096,-0.04048052,0.06988812,0.036993086,0.046469517,0.07100973,0.014338378,0.05610065,0.019572986,0.0042542354,0.0087787155,-0.02668744,-0.064093105,0.03028471,0.0773187,-0.050481286,-0.022894112,0.059944816,0.06457762,0.026724467,0.0072101513,-8.281202e-05,-0.09584187,-0.037935372,-0.06658669,0.02199731,-0.019588748,-0.0494548,-0.03863025,0.004437376,-0.034491103,-0.005083235,0.0433616,0.060316153,0.111686416,-0.0062960736,-0.016504643,0.0044311327,-0.024791028,0.03010529,-0.03728365,-0.027189802,-0.03345206,-0.090944394,0.06421031,-0.020246526,-0.031129211,0.008432266,-0.09612258,-0.0050882413,-0.006948805,0.026804518,-0.002997215,0.014082081,-0.039447844,-0.008382373,0.045683693,0.036041427,-2.4431952e-08,0.004637842,-0.012103852,0.031465262,-0.043866128,0.045250308,0.039591152,0.051464323,-0.0012755562,0.07112405,0.020779941,-0.025482386,0.031993553,0.06753061,-0.009508957,0.07077219,0.08374523,-0.040711846,0.036191486,-0.041015673,-0.037217587,-0.031700816,-0.02004437,-0.14249574,0.08320634,0.06876331,-0.051035017,0.023135228,0.030268243,-0.043914188,-0.057033435,0.021753395,0.0029538423,0.015864069,-0.056840513,0.022560768,0.034266505,0.025499398,-0.002744721,-0.043225348,0.051226888,-0.040946182,-0.01965449,-0.019126512,0.029868906,0.06902442,0.056595568,0.0040519205,0.006739579,0.009460021,0.01307397,0.041411154,0.017240424,-0.058692787,-0.10741242,-0.06609133,-0.019462496,-0.005799323,-0.078269534,-0.008505917,-0.071027294,0.029337356,0.0016388862,0.10651553,-0.048776813 +3.6.3.12,A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A bacterial enzyme of di(heterotetrameric) structure that is involved in K+ import. The probable stoichiometry is one ion per ATP hydrolysed.,384,0.99999994,-0.044545505,-0.028142313,0.019038346,-0.028579416,-0.04379703,-0.015174957,0.05058509,0.029554803,0.05309604,0.027995877,0.018465718,0.0027111962,-0.04892572,0.120492,-0.044874806,-0.091823906,-0.07099443,0.036826327,0.080282144,-0.0034847637,0.04978433,-0.0008917405,-0.018845813,-0.0035428407,-0.04240186,0.0949629,0.044169158,-0.017688898,-0.011367765,-0.0076379827,-0.13121682,0.00016859123,0.05123884,-0.014067687,0.05619579,0.12895106,-0.09483908,0.006216056,0.061727624,-0.034123868,0.13480568,0.0057849633,0.036281753,0.06894541,-0.039648954,-0.013332368,0.04164453,0.0498828,-0.029976873,-0.09482052,-0.026507528,-0.02338639,-0.09884719,0.039699595,-0.008105013,0.015835416,-0.03176176,-0.009214462,-0.012911529,-0.047685273,-0.025585385,0.036316443,0.0073376996,0.043269545,0.053278778,-0.032485634,0.048094586,0.051939894,0.03358636,-0.030246416,-0.04082069,-0.0024927426,-0.013951007,0.0042935023,0.02793949,-0.023260485,-0.04190603,0.03155597,-0.01086657,-0.07769637,0.063106,-0.016073877,-0.04427431,-0.026992774,0.044407856,-0.02600224,-0.04313042,-0.020846713,0.030336913,-0.054225247,-0.038643785,-0.024671415,-0.018658433,-0.057730123,-0.09403201,0.024264703,-0.0059574684,0.06028283,0.049740393,0.019429386,0.06571538,0.10233291,0.024807613,0.0077119856,-0.038084082,-0.010235759,-0.019779744,-0.022521898,-0.007598233,0.078243956,-0.07097236,0.018588005,0.03371043,-0.021318724,0.014283516,0.04415436,-0.0042107706,-0.016354024,-0.018103966,0.030416513,-0.0335363,-0.11292457,0.024446165,0.0148812495,-0.051756628,0.058764152,-0.02015377,1.5870235e-33,-0.02644075,-0.01712331,0.06091806,-0.030713633,-0.017466724,-0.031502787,-0.06440056,-0.07578609,-0.06221648,-0.124943525,-0.058114637,-0.022362188,0.013837051,0.029897785,-0.010946677,0.00039057992,-0.062454294,0.10841713,0.13907263,0.0032072738,0.062383402,0.012580519,-0.02055535,0.06290511,0.064999275,0.024868792,-0.02082302,0.010926263,0.034247242,0.006434284,0.026156776,-0.07419382,-0.0758113,-0.018785296,-0.023994196,-0.06278031,-0.11643801,-0.028650802,0.058038436,-0.05686754,-0.13520467,-0.054769572,-0.0075824587,0.0133343255,0.0037874046,-0.0071396795,-0.021493586,0.048699364,-0.024251621,0.046506897,0.018631494,-0.0834687,0.06837653,-0.06217088,-0.06935397,0.0509693,0.06784599,0.0026467864,0.01091821,0.033774517,0.10789928,0.1092397,-0.06274233,0.020868544,0.0027385869,0.04716902,-0.1080847,-0.06890405,0.07673429,0.1086772,-0.10109802,0.00757017,0.004459393,0.009454989,0.035207994,0.013951875,-0.007925636,-0.017521769,-0.025454339,0.05578072,-0.047803983,-0.0707833,0.005625,0.0064470875,-0.05972371,-0.030106008,-0.017383596,-0.04888505,0.010911214,-0.007844431,0.08694168,0.006134951,-0.045633946,0.064661935,0.07236454,-3.169297e-33,0.09785024,-0.040886782,0.09796524,-0.055627592,-0.046171885,0.036353998,0.019093951,0.015087377,0.043200742,0.0013686486,-0.0036824022,0.028137712,-0.010009128,-0.011767258,-0.025997324,-0.016038515,-0.012102467,0.09152681,0.034093063,0.037175953,0.053966783,0.027250852,-0.0010980935,0.009637612,0.0049989717,0.014449443,-0.010712988,0.09224391,0.00045256966,0.017005455,-0.012355769,0.027463602,-0.025565647,-0.036762893,-0.09482617,0.038497057,0.006144158,0.039396834,-0.01816181,0.048615497,0.06133833,0.06898071,0.061986905,0.0058434675,0.0237874,0.044893872,-0.018620651,0.02070181,0.024852931,-0.071916565,0.011556867,0.104732454,-0.08627729,0.020758772,0.050677985,0.0548042,0.012793295,0.05228939,-0.025631122,-0.07558862,-0.08955826,-0.17662588,0.041369397,0.027193656,-0.018546473,-0.050481666,0.0036256958,-0.04156219,-0.0036214213,0.036734175,0.013290188,0.091353275,-0.021442786,-0.020878484,0.003996141,-0.014323932,-0.031193988,-0.014933098,-0.017070621,0.0071433526,-0.027619742,0.0033902093,-0.04704027,-0.01600603,0.0059454404,-0.077243276,0.0026580358,0.035367027,0.019519415,0.009129141,0.016784217,-0.033506546,-0.025929064,0.006829613,-0.0076063173,-3.175258e-08,-0.0025079367,-0.030642966,0.057595465,-0.0066117817,0.06858549,0.024557289,-0.01128241,-0.026933804,0.0852642,-0.012397789,0.015738638,0.022756694,0.036648907,-0.022394309,0.049796965,0.07894471,-0.078781195,0.01201304,-0.04456511,-0.054037854,0.024466967,-0.024496634,-0.09330387,0.13721532,0.06698526,-0.0121834325,0.017955765,-0.018532077,-0.07800453,-0.08955443,0.0320064,0.023187572,0.0023698036,-0.025906501,-0.045687266,0.039827105,-0.04723682,0.025510194,-0.05748391,0.03403047,-0.022460142,-0.03885922,-0.081076086,0.034771994,0.04246211,0.10354217,-0.010751178,0.044109367,-0.05415785,-0.030113079,0.056755282,0.014476531,-0.061366305,-0.09784654,-0.08867718,0.037300557,-0.02306725,-0.06119925,-0.039049752,-0.055176497,0.10197114,-0.025355702,0.1493927,-0.024626499 +3.6.3.14,"A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. Within this complex, the gamma- and epsilon-subunits, as well as the 9-12 c subunits rotate by consecutive 120_degree_ angles and perform parts of ATP synthesis. This movement is driven by the H+ electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archebacterial) enzymes have a similar structure but, under physiological conditions, they pump H+ rather than synthesize ATP.",384,1.0,-0.052469514,-0.04107736,-0.060205765,-0.07108251,0.0147729805,-0.0051138224,-0.04070181,0.0058348617,0.094940305,-0.0420205,0.07356926,-0.030705431,0.0055645946,0.06031551,0.0047492734,-0.1119961,-0.082265325,0.09388232,-0.028377796,-0.032903176,0.06041107,-0.028869838,0.014928501,-0.029194947,-0.033905916,0.02270201,0.029121403,-0.011631725,-0.05439477,-0.05921725,-0.16439833,-0.044288445,-0.01666692,0.0046460154,0.013077887,0.10673862,-0.103134915,-0.024896525,0.011808926,-0.03288238,0.06758003,0.024779828,0.03264513,0.053489793,-0.08314824,-0.02266761,0.07561021,-0.036013998,0.012314557,-0.025751773,-0.0007982486,-0.027819127,-0.03128421,0.06448361,-0.034358107,0.08100059,-0.05848661,0.01954811,-0.014258666,-0.0039201933,0.010788984,0.027977321,0.04320674,-0.011144747,-0.00671746,-0.060965683,0.0094938185,-0.015811699,-0.012243258,-0.0680621,-0.011190306,-0.017365213,-0.07842327,0.013883039,0.014494116,-0.016329834,-0.018723946,0.037049744,0.03620263,-0.019686885,0.043251444,-0.006784565,0.0014344869,0.0676578,0.05812218,-0.03343572,0.015621697,0.0013525062,0.015113365,0.04028393,0.03714783,0.018776162,-0.05952563,-0.041158523,-0.060485777,0.01317142,0.024855323,0.06892501,0.0086599775,-0.025696283,0.0991963,0.06615727,0.056199368,-0.02338531,0.04319946,0.01567118,0.005685494,0.08024829,-0.024590375,0.04764308,0.00935467,0.013631683,0.050707117,-0.05580521,0.034636036,0.07139848,-0.0015009792,-0.020292442,-0.028195245,0.05925082,-0.036989447,-0.061000284,0.011759941,0.04112622,0.0065302276,0.031532656,-0.15931441,6.3419987e-34,-0.006303982,0.00028662718,0.03545103,0.02667191,-0.032690007,-0.028554179,-0.05223476,-0.046553973,-0.040806487,-0.022495653,-0.06571738,-0.008921978,0.014815623,-0.01824401,0.004492463,-0.06859394,-0.039816655,0.03858502,0.052409403,-0.045137737,0.040722866,0.04879081,0.04220945,-0.07851117,0.06833112,-0.0016689549,-0.022742553,0.009436205,0.038269334,0.029190412,0.016965017,-0.12541474,-0.11865914,-0.0034004392,0.041638516,0.011329689,-0.08228895,-0.00201799,0.025925454,-0.03657941,-0.08277737,0.012186816,-0.02965392,-0.056040246,0.0699463,-0.0100495955,0.0035287633,0.07939862,-0.015357781,0.05752412,0.004302449,-0.06361631,0.12657419,-0.05777494,-0.013203627,0.028068675,0.020353742,0.046939947,-0.028950043,0.058323976,0.098506704,0.09120086,-0.04067501,0.019111866,0.042648103,0.061137926,-0.113494456,-0.10917847,0.06651958,0.055581436,-0.03948011,-0.0125071285,0.03215159,-0.008131515,0.024320515,0.029636297,-0.04405146,0.008849862,-0.025551463,0.0039928067,0.034088004,-0.028343124,0.08166254,0.005304117,-0.039489027,-0.03762023,-0.008613354,-0.021266395,-0.012240001,0.030246107,0.10931245,-0.014428985,-0.02568494,0.03336375,-0.022892866,-1.7524387e-33,0.05448151,-0.08399044,0.029153302,-0.16016659,-0.07277242,0.08566474,-0.028674286,-0.054272827,-0.041823957,-0.056526434,-0.009463489,0.011488175,-0.09534848,-0.045354925,-0.03433592,-0.051404096,-0.025141777,0.070475325,0.051545255,0.019559452,-0.013003163,0.089670226,0.04990972,0.13777591,-0.026678167,-0.022709727,0.0049406677,0.064914376,0.017252527,0.03045302,-0.040033154,-0.0019615812,0.005773116,0.04071236,-0.07481067,-0.062380712,0.01585445,0.03217569,0.06516826,0.07364511,0.056241512,0.016715607,0.038912836,-0.0823365,-0.0154215405,0.069818415,-0.015914807,0.012182015,-0.071752496,-0.07325124,-0.038357325,-0.03153468,-0.04393254,0.051670533,0.044415556,0.028037854,-0.0034952878,0.052294713,0.0871888,-0.049070396,-0.06881279,-0.06580438,0.032900155,-0.06576837,0.0051768627,0.018551081,-0.018063365,-0.050622005,-0.024584262,0.039898988,0.007939457,0.026759647,-0.0025296814,-0.020798137,0.040644813,-0.015921872,0.07753007,-0.053491212,0.00045399836,-0.07209135,-0.03887538,0.038399056,-0.07902869,-0.06353029,0.018390741,-0.03885363,0.03755969,0.07454625,0.040327832,0.02886765,0.07789558,-0.013943528,-0.027713822,0.03008948,0.07788128,-4.4540574e-08,0.0448765,0.048128683,0.045998547,-0.009903469,-0.0035228594,0.06516021,0.055523295,0.014856722,0.08931407,0.031098275,0.010386994,0.064090066,0.04529448,-0.043857593,0.044895153,0.070334695,-0.07380669,0.06969019,-0.0072931894,-0.02080666,0.017034562,0.006561225,-0.11180508,0.07875277,0.10632281,-0.069873944,-0.044581085,-0.03725715,-0.023384282,-0.04937851,0.023465537,0.033126913,0.017863734,-0.04019551,-0.08838755,0.02314696,-0.02187686,0.0068315943,-0.09138016,-0.0026792618,-0.013317048,-0.08370842,-0.043250266,-0.013835134,0.044240035,0.06859379,0.022560982,0.05110319,-0.003522047,0.027036734,-0.0056763473,0.0019665926,0.03184478,-0.08178084,-0.10989526,-0.00914738,0.018077988,-0.08844236,-0.028837109,-0.0008524832,0.11615826,-0.0019285589,0.10798944,-0.01976521 +3.6.3.15,A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. An enzyme found in alkaliphilic bacteria that is similar to EC 3.6.3.14 (H+-transporting two-sector ATPase) where Na+ replaces H+.,384,1.0,-0.025264194,-0.05211621,0.011003066,-0.010882904,0.010711916,0.032077987,0.018532012,-0.009352284,0.045750305,-0.012256534,0.041364037,-0.11119685,0.025984209,0.0833634,-0.06362023,-0.09056612,-0.06924616,0.06817923,-0.010676131,-0.07130238,0.04375339,0.035012525,0.0055913595,0.0048577483,0.0028428382,0.043292053,-0.012291691,-0.051617946,-0.025864817,-0.052507315,-0.09076727,-0.070675336,0.038396753,-0.044453803,0.03573483,0.087175086,-0.08883517,-0.016475381,0.033534445,0.017217102,0.118585706,0.03032679,0.03636934,0.010244082,-0.04793494,-0.03078893,0.05260489,-0.049324676,0.009761807,-0.034715686,-0.058079354,-0.053030215,-0.03603782,0.07978416,0.024897132,0.039379362,-0.04941145,-0.011983701,-0.0073630554,-0.029575603,0.019115372,0.06292967,0.094059326,0.020685699,0.05561544,-0.076099426,0.012907563,0.015465317,-0.024707517,-0.049065776,-0.058970854,-0.064210095,-0.019754492,0.034224473,0.027677782,-0.0513932,-0.01125727,-0.0072765127,0.0017445915,-0.022463508,0.033947032,-0.048960138,-0.06389075,0.015377898,0.03600285,-0.061037257,0.028188748,-0.05480745,0.010898298,-0.025096508,-0.03439914,-0.042066302,0.021669196,-0.05359243,-0.059419893,-0.02332636,-0.039178196,0.11632017,0.020554228,0.015478637,0.052151926,0.10928183,0.028882025,-0.011274807,0.018246492,-0.02620277,-0.025537048,0.058635,0.030585412,0.06522022,0.0060657104,-0.01049427,-0.0016513166,-0.028749477,0.021167397,0.115133986,0.0002132624,-0.043879602,-0.025911154,0.016015226,-0.018163957,-0.12435719,0.035580605,0.014157036,0.029932693,0.041974835,-0.09664746,4.0113846e-34,-0.003727587,-0.04065906,0.008452277,-0.03286269,-0.004301211,-0.029613154,-0.11168739,-0.023281941,-0.031727504,-0.11780958,-0.0313892,0.04060718,0.04705938,0.034671694,-0.012016574,-0.05409731,-0.08271045,0.0140069015,0.14054312,-0.007070229,0.002130337,0.04214907,-0.021380868,0.032644782,0.06702054,0.014281051,0.021374743,-0.05563772,0.074166104,0.0148972,0.05260785,-0.073032975,-0.11679919,0.011758349,-0.0026791485,-0.051895216,-0.06557067,-0.024271028,0.0524598,-0.03480402,-0.11029555,-0.023612425,0.011428935,-0.02781354,0.06608871,-0.0264893,-0.06795772,0.034919407,0.018874075,0.0250779,0.011232376,-0.09751923,0.12270162,-0.08563223,-0.052071802,0.03389413,-0.025372662,0.059705958,-0.018513512,0.061989512,0.04210549,0.120937325,-0.05895569,0.037219785,-0.015110156,0.053608984,-0.09726541,-0.09897322,0.106611475,0.04368347,-0.10815278,0.010378977,0.044412103,0.05082895,0.03359935,-0.021117771,-0.09668638,-0.016882328,-0.0150235165,-0.00058084767,-0.065916665,-0.083442844,0.054804303,0.047313556,-0.031471882,-0.03246531,-0.05494811,-0.0013532785,-0.0011139599,0.0014581387,0.09494665,0.03781438,-0.067451075,0.07023515,0.01290383,-1.9500832e-33,0.08757106,-0.045455586,0.021550724,-0.06406195,-0.059577487,0.047220327,0.021689182,0.031447414,0.0064842068,-0.009447326,0.029574547,0.026102401,0.046905663,-0.045529343,0.031175116,-0.037240252,0.023028005,0.040479373,0.040406063,0.032906145,0.07557295,0.03866209,-0.02161934,0.0017665875,0.0062575783,0.016364064,-0.056802616,0.06871705,-0.00053155876,-0.012859164,-0.041285023,0.0115518095,0.0041883695,-0.045312483,-0.11314122,0.006627557,0.03820577,0.006826859,-0.06089448,0.032792404,0.06008459,0.022026254,0.08383055,0.045598693,0.034823805,0.11039114,-0.031031257,0.06804714,-0.007744815,-0.05852872,-0.023069412,0.0032011978,-0.044720847,-0.007395047,0.034077827,0.054504916,-0.003483359,0.063375264,-0.006233007,-0.044035368,-0.04579393,-0.072433256,0.07663448,-0.048773218,-0.02543409,0.009339232,-0.0021322137,-0.027966397,-0.016055617,-0.010338728,0.07145153,0.038187142,-0.022527147,-0.06137242,0.008915127,0.0071042785,-0.026992023,-0.032856748,0.013336148,-0.061798654,-0.013733509,0.058501326,-0.018774644,-0.04537086,0.06679156,-0.03828345,0.000518355,0.052413598,0.011851945,0.009441725,-0.010871508,-0.0091017345,-0.051165562,-0.0046311654,-0.0389637,-3.486372e-08,0.056388143,-0.03638069,0.030286422,-0.043462798,0.0806899,0.06297772,-0.01444518,0.039783612,0.09534032,0.03447706,0.010695265,0.037760507,0.0067433384,-0.017591767,0.0693377,0.05421859,-0.0420065,0.060154244,-0.044740465,-0.02494074,-0.00987522,0.005775922,-0.121154465,0.11460532,0.044722352,-0.024177488,0.056402538,-0.02196935,-0.05592193,-0.10825878,-0.02334706,0.06202748,0.036618523,-0.01316004,-0.052930698,0.023828369,-0.042503994,0.026191967,-0.09018144,0.026092105,-0.025852246,-0.038012333,-0.07264762,0.008899254,0.06345923,0.084535465,-0.014187205,0.01340143,-0.02501467,-0.011807112,0.039725337,-0.033551607,0.023085065,-0.041940033,-0.0884327,-0.0005356497,-0.03125767,-0.1450045,-0.030414313,0.04051888,0.12316076,-0.010952374,0.12375516,0.034599658 +3.6.3.16,A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. A bacterial enzyme that usually contains two subunits where one (with 12 membrane-spanning segments) forms the 'channel' part and the other (occurring in pairs peripherally to the membrane) contains the ATP-binding site. Exports arsenite and antimonite anions.,384,1.0,0.024678867,-0.07440594,0.007570022,-0.011665936,-0.0048661926,-0.02456869,0.0931562,0.01995986,0.06404591,-0.026592748,0.022712518,-0.089557186,0.01762591,0.1075138,-0.083217666,-0.119122446,-0.10041788,0.047986057,0.011446046,-0.062952206,0.045527697,0.03507517,0.024387922,-0.02693461,-0.024962025,0.041462857,-0.01353365,-0.06153264,-0.04524294,-0.004994984,-0.10000237,-0.036907736,0.02527562,-0.000387033,0.053803097,0.10960042,-0.077901855,0.023755284,0.032823782,-0.015258169,0.10713964,0.030220168,0.002134961,0.016447745,-0.06709853,0.0034068886,0.038661085,-0.02673045,0.0073898523,-0.032089807,-0.06906645,-0.037917744,-0.06692534,0.113760054,0.021714669,0.018769631,-0.017708715,-0.020556128,-0.027997471,-0.036473133,0.050122406,0.052358214,0.05803858,0.042819276,0.061169293,-0.057052966,0.008304196,0.06519619,-0.045853365,-0.017739702,-0.008745396,-0.06418976,-0.060447425,0.02820296,0.041669853,-0.07757104,0.014468964,-0.0066727265,0.008410955,-0.04217216,0.013272936,-0.02904962,0.0026189226,0.0099248355,0.05469268,-0.052834343,-0.0047460357,-0.040857375,0.055174444,0.02364733,-0.06808755,-0.015640277,0.012755908,-0.06311969,-0.05700017,-0.029677613,-0.022254093,0.06952902,0.0012348972,0.03375222,0.04158384,0.06704565,0.043692026,0.0048784236,-0.022589805,-0.012875656,-0.06535507,0.0047224294,0.025761863,0.05807794,-0.020618048,-0.013442418,0.032568194,-0.033056203,0.05832751,0.11061686,0.04158592,0.023764107,-0.0077672377,0.039927155,-0.0653155,-0.099174,0.05067958,0.06444008,0.015238599,0.032231394,-0.11517217,-1.3460672e-33,-0.017074425,-0.031557508,0.0002132871,-0.026535748,-0.026254997,-0.014961939,-0.06195923,-0.04166168,-0.034846034,-0.037925,-0.053549543,-0.041195896,0.011802813,0.06285427,0.026041236,-0.057617936,-0.0971573,0.051450618,0.13590102,-0.012372359,-0.0064550405,0.027009351,-0.02511021,-0.0059017558,0.07584887,-0.010314043,0.0042900504,-0.011530025,0.052811157,0.013122107,0.02428764,-0.047489926,-0.084439255,-0.0052526915,0.030748697,-0.08907256,-0.09524725,-0.009409161,0.033815995,-0.036702253,-0.10046207,-0.047579717,0.0244144,-0.031750057,0.07275018,-0.036674287,-0.09427781,0.019636482,0.009255231,0.019531408,0.00294344,-0.07225022,0.108725354,-0.09841424,-0.09495942,0.039790224,-0.0050421464,0.06576047,-0.0103428885,0.048694786,0.05829149,0.08001173,-0.081668966,0.019420125,0.0006093826,0.08844802,-0.06834356,-0.07010882,0.0885511,0.029997306,-0.121684,1.9551328e-05,0.053349648,0.031562038,0.020764543,0.009426543,-0.056968376,-0.010898037,0.01331962,0.034557816,-0.07697352,-0.075422406,0.05739125,0.040094804,-0.028511677,-0.013426111,-0.04006143,-0.034406565,-0.01517687,-0.032646973,0.14731522,0.046992633,-0.12029079,0.07088773,0.020168426,-4.6513756e-34,0.084980704,-0.047039032,0.066557005,-0.0814969,-0.07003126,0.03002,0.0075903637,0.025853414,0.019450689,0.0021251442,-0.005559342,0.023378095,-0.0050967173,-0.07360933,-0.011528426,0.006670199,0.061641578,0.064718075,0.06251281,0.042857513,0.044671323,0.03801209,0.010393782,0.012481833,-0.05838985,-0.0068920976,-0.037930485,0.044042364,-0.0012040905,0.02216797,0.016692188,0.027877953,0.029393045,-0.09419126,-0.10979064,-0.0139226755,0.04921702,-0.017901838,-0.05412407,0.052817762,0.100705236,0.05510759,0.07649857,0.05469546,-0.00825877,0.07280435,-0.05231185,0.07654739,-0.033959422,-0.055000853,-0.029371625,0.024296092,-0.012862548,-0.019544296,0.054859616,0.016664624,0.015831616,0.04255607,0.0084047895,-0.07966336,-0.053895134,-0.10927616,0.07523678,-0.03290928,0.017416336,0.020956367,-0.023923038,-0.030324409,0.00085726305,-0.015722616,0.015069192,-0.007908956,-0.053832892,-0.07613919,-0.005779783,0.0073531936,-0.03640066,-0.06275536,0.017774748,-0.024350554,-0.040506713,0.07600244,-0.03921699,-0.031789258,0.080122136,-0.06268683,0.033750456,0.088812895,0.0051078247,0.0145703675,0.03366019,0.020189999,-0.0077518895,-0.00930704,-0.02825812,-3.7686746e-08,0.04092458,-0.01803083,0.03697144,-0.044171177,0.032764796,0.041346032,0.001997056,0.037524495,0.10389333,0.019319745,0.013385381,0.040321574,-0.00040631206,-0.007959857,0.06628141,0.050673913,-0.071495466,0.059912797,-0.04150715,-0.04602206,0.01506369,-0.0066142133,-0.089619726,0.08511727,0.054585367,-0.03943292,0.016720755,-0.015614825,-0.06510096,-0.110059,-0.028011082,0.04835601,0.010259191,0.0015228939,-0.08023471,0.050108634,-0.022140644,-0.020118754,-0.085183874,0.02506638,-0.027450083,-0.04401344,-0.03507032,0.030846056,0.05593203,0.086302094,-0.04543884,0.032599002,0.0072454344,0.0007059045,0.04791484,0.03017565,0.03196973,-0.043640897,-0.04603203,-0.0009643397,-0.03152151,-0.08840621,0.00069597363,0.03916427,0.1116231,0.0032269452,0.08924812,-0.03236285 +3.6.3.17,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Family of bacterial enzymes importing ribose, xylose, arabinose, galactose and methylgalactoside.",384,1.0,0.0054636043,-0.099038884,-0.010188548,-0.03624978,-0.07495215,0.045337826,0.02953894,0.010190867,0.0631194,-0.042863447,0.028563684,-0.024928465,0.029440748,0.11995897,-0.031619005,-0.06586647,-0.071720615,-0.012055754,0.0455377,0.025866348,0.09959992,0.065218486,-0.029735355,0.018236127,-0.036340676,-0.019239908,0.028708795,-0.040439747,-0.056023803,-0.032194562,-0.116726495,-0.011463023,0.03136213,0.018847793,0.054754376,0.10338619,-0.021048205,-0.02684335,0.10978752,0.008077903,0.10686243,0.0016604743,0.11205446,0.068458244,-0.10195646,-0.0050124563,0.03710657,0.053480968,0.030772198,-0.014684281,-0.03731872,-0.025985152,-0.051584303,0.012589774,0.0066554295,0.043131515,0.015634501,-0.026124131,0.00086372066,-0.02384797,-0.01623985,0.023565978,0.06409099,0.085403234,-0.017896185,-0.030525144,-0.01733437,-0.0033373432,-0.00013779718,-0.06860838,-0.0928641,-0.058772873,-0.06929968,0.06023732,0.048822682,-0.026137909,0.012274567,-0.006846158,-0.07224008,-0.06364092,-0.0050523975,-0.055685572,-0.049329296,-0.012763158,0.010034687,-0.028469598,0.01852087,0.019117678,0.022762528,0.036265954,-0.014337396,-0.04630285,0.051257033,-0.0809367,-0.048868254,-0.03546936,0.0060439254,0.047785215,0.033085205,-0.059609447,0.055946663,0.047505345,0.064318895,-0.00021455878,0.015893657,0.022919081,0.00453672,0.020267218,-0.04134209,-0.008258792,-0.0016204695,0.033108566,0.025636379,-0.061461184,-0.027685657,0.0822418,-0.036719292,-0.040047668,-0.10325945,0.006685097,-0.06029846,-0.1319972,0.045419253,-0.03895158,-0.034897916,0.052117307,-0.08637778,5.9470472e-34,-0.05189625,-0.009823752,0.02880312,-0.05537304,-0.011460198,-0.011941434,-0.03959971,-0.022686299,-0.030459534,-0.077115834,-0.05080835,-0.031157225,-0.0051557915,0.046865217,-0.016916178,0.02818231,-0.05532507,0.045631673,0.07087965,0.018840123,0.03051665,0.049757034,0.009732682,-0.04954662,0.08637946,0.030398818,-0.008981021,0.0037793892,0.090866454,-0.019509686,0.04003197,-0.05739504,-0.12269737,-0.021709891,0.025375308,-0.031908933,-0.051555745,-0.0017195024,0.09192531,-0.06396276,-0.06603156,0.0018112716,-0.020179307,0.046223976,0.05056095,-0.027783819,-0.04323013,0.048327796,-0.030359432,0.048780262,0.051681854,-0.12613942,0.108123705,-0.06521382,-0.0038629863,-0.01148194,-0.008683294,0.04601914,-0.05127399,0.049217157,0.09350178,0.08944394,-0.04802492,0.036124814,0.0020429057,0.060736205,-0.050531175,-0.12623419,0.042309355,0.08965034,-0.033329856,-0.0065614544,0.04009939,0.012191829,0.059896875,0.013493048,-0.06986344,-0.048023913,-0.0045387605,0.042170607,-0.008309926,-0.06520943,0.05323212,0.01621613,-0.07089386,-0.030468605,-0.0127028525,-0.022006847,0.0044049243,-0.008112683,0.09293597,0.04115398,-0.04363735,0.12351811,0.037609756,-2.121616e-33,0.11228284,-0.03780539,0.12548578,-0.12286031,-0.048643894,-0.0043518217,0.020069228,-0.02912993,0.03158855,-0.047072664,0.03460389,0.029067833,-0.034923334,-0.062519915,-0.003764746,-0.06461746,0.022278447,0.053761233,-0.037653673,0.0029966154,0.016359363,0.020763753,0.003922726,0.034904532,-0.036196552,-0.008265933,-0.026725017,0.1123799,-0.011574901,-0.0051466506,-0.012692179,0.049228404,0.011586249,-0.065555274,-0.09341817,0.0074641802,-0.012630574,0.08208455,-0.010688933,-0.0028075583,0.045993637,0.114641376,0.0067051016,0.040916447,-0.007973314,0.09090438,-0.014071459,0.011932937,0.023816245,-0.011430823,-0.03429127,-0.005490933,0.00018445823,0.0072868885,0.05095962,0.106814355,-0.008359358,0.057089265,-0.005615759,-0.106672816,-0.09130151,-0.06598921,0.09348845,-0.056928433,0.02086846,-0.014658002,0.013127841,-0.062293667,-0.007312177,0.05588248,0.0478857,0.061986513,-0.06191812,-0.0052335705,0.006549184,0.049108896,-0.065952465,-0.072667345,-0.052160047,-0.008207634,0.016775802,0.064955205,-0.03402895,0.0038378933,0.06858108,0.000106527834,0.0075451527,0.028863726,-0.0007080528,0.06362158,-0.009648171,-0.015366045,0.033871945,-0.005263451,-0.020297997,-3.2801196e-08,0.005882396,-0.0053028064,0.046940085,-0.080521956,0.0021041296,0.052975073,-0.06042579,0.0074080187,0.106636025,-0.016708246,-0.045100555,0.0840564,0.0073663965,0.025420919,0.05859395,0.027635485,-0.06759618,-0.00626794,-0.011840005,-0.020664472,-0.014598395,-0.039273735,-0.05213299,0.12540434,0.021050053,-0.05581289,0.019810833,0.023920126,-0.024176553,-0.04000642,0.025992796,0.02463624,-0.012266024,-0.029023623,-0.06065677,-0.010637196,-0.024750955,-0.00024373303,-0.052360352,0.06556734,0.040889442,-0.06558026,-0.07393832,0.0030410222,0.042230412,0.05008056,-0.02775745,0.03934655,-0.00166753,-0.0060886093,0.06746997,0.012335776,-0.056826726,-0.070376635,-0.047339298,0.00866561,-0.05246774,-0.060378768,0.0007738354,0.007758285,0.045431983,-0.03439162,0.1801126,-0.04981757 +3.6.3.18,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports lactose, melibiose and raffinose.",384,1.0,0.0053509288,-0.089656204,-0.00029728978,-0.011205522,-0.060991038,0.052496012,0.03174517,0.0476448,0.059000615,-0.058175266,-0.023354786,-0.068331495,-0.010509454,0.11847456,-0.036450084,-0.07075405,-0.07022663,-0.003341645,0.048735302,0.013388762,0.08478072,0.04474084,-0.027564604,0.043868512,-0.022692662,-0.0039507505,0.04266915,-0.016836954,-0.065111764,-0.03708736,-0.1178524,-0.03158866,0.024390215,0.012642238,0.044743843,0.077139094,-0.0030906803,-0.015333075,0.08497393,0.009301863,0.111710705,0.025886364,0.110259436,0.10428375,-0.08681869,0.00060658564,0.052111037,0.03234011,0.0021196736,-0.024063157,-0.056852438,-0.033924043,-0.043777958,0.051494338,0.012120646,0.045924015,0.007033742,-0.010379475,0.019190785,-0.03736799,-0.015393865,0.013964431,0.07934003,0.07287027,0.022826266,-0.02100569,-0.026854865,-0.01934412,-0.0072770836,-0.06975387,-0.10636407,-0.07247596,-0.025268786,0.04621885,0.047279768,0.012337986,-0.0025110675,-0.0023318394,-0.04505034,-0.027585343,-0.008313771,-0.06096769,-0.050234843,0.004786067,0.0045458116,-0.0388354,0.056967452,-0.008204623,0.052094955,0.017193634,-0.06558783,-0.05501788,0.011279614,-0.06863823,-0.097380355,-0.03985968,-0.006196227,0.03435375,0.056595325,-0.039039087,0.061573427,0.044108193,0.053672045,0.0063017216,-0.0062646554,-2.4189025e-05,0.0014650819,0.011198912,-0.008556505,-0.011337339,-0.009370118,0.039290387,0.047868434,-0.03755302,-0.04641012,0.07286186,-0.05733474,-0.040767375,-0.08519288,0.046135932,-0.0487621,-0.10812979,0.037333433,-0.025760615,-0.02163599,0.038220216,-0.056608055,-7.9256e-34,-0.045440443,-0.044437245,0.060117647,-0.04187157,0.010189241,-0.023919376,-0.044688772,-0.031474404,-0.022817332,-0.09229044,0.0047479863,0.0029856637,0.004483277,0.050023936,0.003279684,0.03925995,-0.054071505,0.020289408,0.05610733,0.0027173208,0.013145061,0.07603928,0.0032992489,-0.046633407,0.07946044,0.01807695,-0.015831763,0.03434111,0.076203056,-0.0036681572,0.04163434,-0.08202322,-0.14371283,-0.004179489,0.02287342,-0.049990714,-0.043948557,-0.0070068804,0.055682864,-0.057001874,-0.10343207,-0.011392261,-0.033236742,0.052893467,0.03567783,-0.073531166,-0.038995028,0.060368653,-0.026262578,0.042323522,0.052078873,-0.14765345,0.1048699,-0.058735467,0.0007673637,-0.017771835,-0.022534654,0.061246786,-0.041432302,0.05540542,0.11464584,0.09385192,-0.032292366,0.011671925,-0.0040811654,0.055622328,-0.06440481,-0.10107812,0.06476183,0.08177296,-0.022989431,0.02340911,0.024216231,0.056608204,0.039339684,-0.0007529714,-0.03749373,-0.05689975,-0.021525465,0.029295921,-0.020760484,-0.101095505,0.042299416,0.047444392,-0.08006561,-0.051844697,-0.05238978,-0.023468766,0.015915744,-0.013812039,0.06435873,0.04841166,-0.04733029,0.11213067,0.060457144,-9.188321e-34,0.109833345,-0.03898205,0.092426844,-0.114916965,-0.045284573,0.0049170647,0.012589419,-0.0004578479,0.010645978,-0.051069368,0.020260463,0.014596098,-0.018272331,-0.029989066,-0.025615389,-0.07023813,0.014403505,0.05379927,-0.015331968,0.0039353194,0.028070811,0.036978126,-0.006103402,0.05257263,-0.04791236,0.020053238,-0.052295234,0.123564616,-0.043012682,0.0044574304,-0.0021860397,0.061449274,0.01417078,-0.07718338,-0.09052553,0.003843463,0.017120544,0.04343338,-0.01138811,0.0027050902,0.027819496,0.104860224,0.028578278,0.0074918116,-0.004250206,0.08290461,-0.005812826,0.017290011,0.05468873,-0.009132429,-0.029485716,-0.0009217844,-0.02273461,-0.017105497,0.0480599,0.099472865,-0.032313928,0.022777045,0.040145665,-0.0857113,-0.0750542,-0.071134456,0.09121636,-0.0556563,0.0060857316,-0.021062506,-0.005765796,-0.06926583,0.0049610506,0.06938236,0.07183829,0.09181781,-0.032935545,0.022047903,-0.0069519104,0.051382188,-0.019792046,-0.05221818,-0.02807251,-0.014919239,0.015280074,0.06190316,-0.008393442,0.009870237,0.051521625,0.029997444,-0.009239038,-0.011889818,-0.01093219,0.041077252,-0.005759292,-0.028121663,0.010885417,0.033818576,-0.015524475,-3.109716e-08,0.04692502,-0.04351475,0.008811006,-0.05968569,-0.017624294,0.061357383,-0.08609656,-0.009638334,0.123891234,-0.032382794,-0.026013827,0.09492579,0.010320739,0.030859398,0.062633686,0.047001973,-0.043894682,-0.018133251,-0.021648,0.002883365,-0.04077282,-0.07083935,-0.05959524,0.12042497,0.05579494,-0.055110287,0.0049503613,0.054665554,-0.04458348,-0.04609249,0.032012694,0.031382237,-0.01887243,-0.023711381,-0.060244303,0.01548176,-0.037091948,-0.011881108,-0.07429565,0.05995557,0.04970064,-0.04996928,-0.07140526,-0.0060685715,0.05308026,0.05205689,-0.02418143,0.024914576,-0.027623264,-0.028400375,0.035855256,-0.0046532056,-0.04445806,-0.01735593,-0.051226903,-0.0060169017,-0.017817091,-0.056694098,-0.020499,0.002068223,0.06863451,-0.0072260383,0.18987162,-0.05703424 +3.6.3.19,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import maltose and maltose oligosaccharides.",384,1.0,-0.00883945,-0.06442083,0.0050033717,-0.003425356,-0.0866655,0.03428119,0.033566106,0.022592904,0.067195036,-0.07097615,-0.005057099,-0.041540407,-0.022539113,0.08604282,-0.044475287,-0.07184707,-0.07015321,-0.016870594,0.056226064,-0.0027713906,0.09335527,0.06995925,-0.025806956,0.030651953,-0.039134227,0.011460965,0.026294291,-0.010417486,-0.03849001,-0.030511986,-0.12158736,-0.024443125,0.026462104,0.016222345,0.0514566,0.09258907,-0.01389475,0.010777025,0.0708724,-0.0040110247,0.12592801,0.01395757,0.1023506,0.12142056,-0.12884708,-0.03678671,0.0020990628,0.017032862,-0.023048406,-0.030753443,-0.067433566,-0.02805693,-0.07136894,0.054661937,0.005412594,0.023181578,-0.0073329825,0.027106186,0.01659603,-0.03235156,-0.010239123,0.040586535,0.07031847,0.087100215,0.03425879,-0.012936459,-0.038428072,-0.026239354,-0.016006242,-0.046875756,-0.094343044,-0.06325613,-0.05366864,0.08323671,0.059916932,-0.020150311,-0.016106708,0.0041374513,-0.068130426,-0.022282362,0.001481236,-0.047976036,-0.0367512,0.027541567,0.0036437353,-0.056158494,0.031483423,-0.007597285,0.045347914,0.010152733,-0.031197524,-0.052227955,0.03102815,-0.07139506,-0.058137435,-0.020355774,0.009061266,0.012758363,0.06351767,-0.026021102,0.050347056,0.04898562,0.049196515,0.019806894,-0.016339075,0.023583688,0.010699542,0.0061877365,-0.021359786,0.011034102,0.0078016995,0.017435413,0.035917345,-0.07582453,-0.041709337,0.056345426,-0.067087546,-0.032794606,-0.05972734,0.03387058,-0.03946988,-0.11373663,0.044978224,-0.04163883,-0.026736679,0.057371557,-0.08837802,3.982069e-34,-0.051655147,-0.058347914,0.043918308,-0.047111858,-0.015784252,-0.016865948,-0.012920041,-0.015102419,-0.02312417,-0.076191306,-0.01585753,-0.024070341,-0.0057264236,0.051638953,0.0014709436,0.019433876,-0.061993428,0.0284851,0.08463974,0.014970331,0.041073535,0.07424961,0.010189316,-0.041721664,0.062426332,0.025825258,-0.036869682,0.030922268,0.06943049,-0.004145552,0.06899346,-0.061937284,-0.13405336,-0.030960875,0.023562837,-0.036073014,-0.055232756,0.005036069,0.106133334,-0.07125519,-0.07486941,-0.015585005,-0.01884064,0.028336288,0.041259255,-0.045113064,-0.03867016,0.06525288,-0.043095373,0.05514568,0.038459033,-0.1314634,0.0691198,-0.040601492,-0.0001375601,-0.009418853,-0.014127978,0.054329313,-0.061011743,0.05092471,0.10099436,0.1047404,-0.021633046,-0.016661813,0.002629429,0.045029543,-0.06185776,-0.114350535,0.03819537,0.0826495,-0.04625431,0.02553517,0.013187276,0.038191196,0.03748454,-0.023810057,-0.05166816,-0.04557456,-0.00727763,0.04256177,-0.019284407,-0.097343005,0.05447732,0.027901646,-0.07533267,-0.04597477,-0.041662488,-0.0009784057,-0.009735198,-0.0052701505,0.06788068,0.04478541,-0.048694286,0.12575574,0.035443902,-2.3558194e-33,0.104958616,-0.05096593,0.12242091,-0.12181731,-0.037065547,-0.0047169374,0.027339023,-0.028128505,-0.0028591778,-0.033191714,0.041620992,0.048605345,-0.032127317,-0.03985621,-0.0052829506,-0.054204095,-0.021787088,0.06535728,-0.004351952,-0.0006084343,0.009864127,0.061902907,-0.010440836,0.054342035,-0.046198573,-0.007537493,-0.034484714,0.116168134,-0.011662693,0.015940525,-0.014366059,0.045633882,0.0039582266,-0.049459286,-0.10600758,0.0059267688,-0.012649661,0.046323095,-0.024042742,-0.010540634,0.05148034,0.095014736,0.003611184,0.0099353045,0.018243846,0.084411,-0.0001780931,0.043836728,0.028631637,-0.0039652893,-0.018675812,0.022502918,-0.05365808,0.0076662465,0.041065224,0.109836265,-0.014109287,0.007099767,-0.005039919,-0.08902716,-0.087978706,-0.07212268,0.1007044,-0.040639795,0.02189145,-0.013258328,0.0071960595,-0.044908695,-0.0087894285,0.08364342,0.047337722,0.058236193,-0.041617654,-0.02776478,0.004081658,0.032723453,-0.041908078,-0.030385656,-0.03654799,-0.022895863,0.017540395,0.07870093,-0.011815033,0.007989076,0.06705082,0.035218447,-0.018554833,-0.00056158367,-0.011132203,0.08303489,-0.0033906382,-0.025147425,0.032078158,0.023463242,0.0028779865,-3.0588133e-08,0.020503247,-0.04403115,0.028208597,-0.060193464,-0.00051891315,0.036762014,-0.08819631,0.00062262395,0.11158479,-0.0018595689,-0.037721183,0.0787193,-0.009161323,0.041736618,0.07959294,0.055765934,-0.06454547,0.024469115,-0.031256553,-0.029055279,-0.048778206,-0.05867288,-0.06286738,0.119142994,0.035021044,-0.048682198,0.012950206,0.030631201,-0.031765245,-0.037887096,0.048282165,0.044958655,-0.020271035,-0.026513502,-0.053405464,-0.015814748,-0.028640365,-0.029905457,-0.076518886,0.049546983,0.03786189,-0.032780897,-0.0739416,-0.008017807,0.070418365,0.06663745,-0.017368091,0.038894355,-0.027696595,0.013369457,0.02401629,0.011440054,-0.057153746,-0.044289786,-0.04647919,-0.008728592,-0.029594174,-0.043792203,-0.007284105,0.006562171,0.07323717,-0.012475271,0.19930463,-0.054917872 +3.6.3.20,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports phosphorylated glycerol.",384,0.99999994,-0.026212914,-0.054425806,-0.024427243,-0.0127459,-0.09516362,0.012498365,0.04078272,0.040423475,0.04214494,-0.08096941,0.024609255,-0.021698672,-0.0050480464,0.11155559,-0.022671636,-0.099537,-0.04470172,-0.03281789,0.033607826,3.532898e-05,0.06238182,0.08194031,-0.040508635,0.027790116,-0.04305271,-0.0030455517,0.0097192675,-0.018711332,-0.024697972,-0.004153951,-0.09835466,-0.021583358,0.017894978,0.01098927,0.051836513,0.08508849,-0.023162644,0.005763596,0.07568186,0.023960082,0.12569167,0.020512376,0.082361646,0.08631649,-0.08259534,0.015208812,0.04602183,0.00854254,-0.006913721,-0.00094758713,-0.030712454,-0.008592028,-0.05893462,0.04095836,-0.008434114,0.03529161,-0.03878026,0.041176196,0.0019764253,-0.0345708,-0.03671161,0.006811351,0.086801216,0.098298125,-0.012316774,-0.04447349,0.0014367423,-0.02163738,0.00448724,-0.031927034,-0.07345559,-0.05222042,-0.027428456,0.05810242,0.0221806,-0.010495778,-0.02846202,0.008199243,-0.048692066,-0.05615879,0.030132636,-0.06318183,-0.045284357,0.021137992,-0.0018851589,-0.0116426125,0.022532368,-0.02886487,0.024378773,0.008560169,-0.015641041,-0.076727845,0.019648317,-0.067211434,-0.08560349,-0.033660963,0.012653352,0.015152223,0.0322578,-0.048319735,0.039218154,0.060892925,0.0405286,0.01028811,0.015055132,0.011634869,-0.00077760534,0.0030607474,-0.005942419,0.008331927,-0.0052857054,0.044407263,0.06722098,-0.069309965,0.0060353363,0.049437746,-0.052518502,0.012529404,-0.092345685,0.015810128,-0.047493152,-0.14549148,0.02287103,-0.0463731,-0.05533906,0.07370413,-0.03560144,-3.0162517e-34,-0.032208323,-0.03006228,0.038784917,-0.04764944,0.0033368552,-0.036822584,-0.035483707,-0.029068027,-0.06321108,-0.101898886,0.033501238,-0.0077858362,-0.021209609,0.09667217,0.010801377,0.042077,-0.05269836,0.040980723,0.09497327,-0.030823026,0.063287996,0.042176384,0.018959017,-0.058934834,0.081333295,0.045571182,-0.013383295,0.039851855,0.07050369,-0.0112462,0.02215322,-0.08947854,-0.10715219,-0.023075176,0.045144618,-0.06441963,-0.04721409,-0.020312151,0.09832589,-0.06284368,-0.086668834,-0.026604757,-0.02864979,0.04350454,0.050619777,0.0002445973,-0.054224536,0.063397326,-0.020313142,0.028034179,0.037767194,-0.13387612,0.1143058,-0.045673396,-0.02524922,0.0025261394,0.0021593794,0.056715474,-0.06294179,0.043830816,0.082452975,0.15172146,-0.03936972,-0.0066641704,-0.008269376,0.067422144,-0.09270906,-0.11071668,0.048165113,0.07586694,0.0045874193,0.045692697,0.026497979,0.0314432,0.037559383,0.010023775,-0.022226864,-0.023074536,-0.029106814,0.03203586,-0.04798734,-0.048653413,0.029470032,0.047289427,-0.058242746,-0.03924234,-0.021005733,-0.044391256,-0.0006838499,-0.015554903,0.07487167,0.053691123,-0.020473044,0.11262226,0.0042487015,-1.119313e-33,0.10742367,-0.03681203,0.11549724,-0.08350955,-0.039393213,-0.0056445324,-0.0023576715,-0.003481632,0.026989069,-0.033356074,-0.0009822336,0.034736488,-0.040880885,-0.0069693415,-0.008875276,-0.06800279,-0.012505985,0.051382367,-0.02696979,-0.01569118,0.034516606,-0.009909335,-0.006154973,0.0800763,-0.04181033,-0.0006071294,-0.048718866,0.09422488,-0.032308206,0.0068225292,0.007374076,0.05844446,-0.015410815,-0.064342804,-0.09207583,0.0106954025,-0.004921819,0.058576114,-0.026711872,-0.04802571,0.053776547,0.09090941,0.04026382,0.0037666014,0.026431076,0.084026136,0.016244333,0.014499511,0.015474957,-0.0008618425,-0.03837103,0.021915162,-0.034458205,0.022081615,0.08325941,0.09751938,-0.02009716,0.039865214,-0.0021017035,-0.107673265,-0.0731838,-0.10350623,0.0805464,-0.013939581,0.024630884,0.020157943,0.03658122,-0.06900513,0.004425728,0.08541407,0.059067465,0.06355164,-0.045712586,0.0017660445,0.0023754286,0.07261,-0.035026938,-0.060099296,-0.04871314,-0.012784164,0.005265739,0.05085097,-0.018883994,-0.004965545,0.044805158,0.005595905,-0.020440351,0.019689249,0.008742129,0.07821315,-0.0041307015,-0.025420856,0.00861595,0.0006859078,-0.029836152,-3.0282283e-08,0.014694633,-0.03451538,0.039450087,-0.091228165,0.00817281,0.05015932,-0.052378338,-0.0019363664,0.11495056,-0.030401682,-0.034595188,0.032538313,0.013737057,-0.020746848,0.06349785,0.08405978,-0.07096221,-0.005923366,-0.0048021143,-0.029786482,-0.026987223,-0.055709917,-0.06595511,0.15624095,0.034977224,-0.057545684,0.0054948363,0.04679281,-0.0634353,-0.02055331,0.01504807,0.008422978,-0.043853354,0.003025366,-0.032391757,-0.03163636,-0.040301077,0.003042441,-0.07366599,0.07765773,0.018403262,-0.01690651,-0.06589585,0.02423425,0.06987774,0.06282459,-0.0029969395,0.01899979,-0.031477027,-0.020954033,0.037322897,-0.00043712003,-0.02673097,-0.06521296,-0.116087176,-0.010096731,-0.060007393,-0.038343694,-0.061227776,0.01806826,0.032322418,0.010154637,0.18526281,-0.0044129477 +3.6.3.21,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.",384,0.99999994,-0.0421886,-0.07324967,-0.0049875835,-0.033921108,-0.077278785,0.031642884,0.030404106,0.024469528,0.052855764,-0.06682796,0.017493911,-0.049441434,0.0008263441,0.1250514,-0.04927165,-0.058415543,-0.08032207,-0.036875498,0.061727658,0.0006363087,0.062826894,0.092812166,-0.04815799,0.007104877,-0.031426486,0.0012665505,0.024187798,-0.014885748,-0.025848748,-0.050728664,-0.11808034,0.011319639,0.019911557,0.0062457547,0.07162967,0.08090887,-0.039979663,-0.010769499,0.09293607,0.038908873,0.09980809,0.036369752,0.07875731,0.0994827,-0.087001026,0.012379207,0.05058048,0.02213844,-0.034638554,-0.01687895,-0.026951622,0.0013825595,-0.060339402,0.053629648,-0.021055412,-0.0067171226,-0.031323694,-0.011146408,0.00782226,-0.034806434,-0.008468923,0.01984991,0.06911461,0.079560205,0.019022334,0.0062200055,-0.025670327,-0.025066635,0.003004325,-0.029123623,-0.09153344,-0.0745119,-0.045125656,0.09335018,0.05258971,-0.0058935573,-0.022405986,0.0010997007,-0.036152367,-0.052455086,0.0035273638,-0.03719441,-0.042201504,0.037204277,0.017795686,-0.04177269,0.0077605373,0.02527399,0.0142610455,0.015448982,-0.013897685,-0.045718793,0.020955054,-0.07884658,-0.06312303,-0.020055773,0.009493951,0.025865907,0.024636563,-0.030117372,0.05292318,0.042797633,0.040121414,0.019185951,0.020628208,0.004685664,0.013365169,-0.0014789581,-0.013475325,-0.0033124292,-0.025601177,0.021260438,0.04004794,-0.084698305,-0.017879138,0.05866083,-0.044594854,-0.01026125,-0.09476507,0.027269552,-0.048206337,-0.13499294,0.021809697,-0.008236412,-0.041758604,0.067523785,-0.094176345,9.108749e-34,-0.06076765,-0.03579062,0.056949593,-0.0731192,-0.012213359,-0.0053746095,-0.02488311,-0.03469357,-0.013451235,-0.093662634,0.0007497297,-0.026349641,-0.0013756806,0.06578199,0.00532121,0.02683102,-0.06981748,0.03968047,0.062884055,-0.016477475,0.050524537,0.085330285,-0.0129062375,-0.025016611,0.0960122,0.015735593,-0.0042699124,0.012810182,0.05668781,-0.014285964,0.029086752,-0.070901185,-0.11902929,-0.034671947,0.011031805,-0.071091555,-0.054073516,-0.015332941,0.08704559,-0.08113206,-0.099392705,-0.00498425,-0.039517596,0.0485544,0.041101504,-0.033029724,-0.04256515,0.07779017,-0.061037187,0.045537986,0.05538191,-0.12662862,0.0812333,-0.07406578,-0.006473823,-0.014351266,-0.02719604,0.06511922,-0.050987706,0.040255398,0.12424677,0.11105079,-0.038866308,0.0012942057,-0.023360051,0.058759652,-0.083466895,-0.12868349,0.06776544,0.08699169,-0.015648982,0.044190627,0.024727596,0.04220681,0.035705585,0.008933602,-0.057346962,-0.029225212,0.010675094,0.04017488,-0.03484022,-0.08113557,0.053872988,0.02027202,-0.052876346,-0.06754169,0.01431411,-0.012796343,0.013078051,-0.021529485,0.08597083,0.047810692,-0.060342222,0.10773202,0.031635344,-2.2093536e-33,0.089231774,-0.053282533,0.086790025,-0.11478509,-0.047780108,0.016970271,0.0193147,-0.017071754,0.020823035,-0.052259333,0.021676993,0.045886666,-0.038624164,-0.033115014,0.016258206,-0.096035026,-0.02331352,0.059344728,-8.125255e-05,0.011125993,0.023687875,0.0010545175,0.017426837,0.0647239,-0.050043017,0.019384122,-0.05332753,0.10977248,0.0038876052,0.032416195,-0.011868107,0.07889397,-0.0024251654,-0.05725428,-0.081371516,-0.0005330675,0.03161912,0.08494294,-0.030401107,-0.043937925,0.050032094,0.079560846,0.009471654,0.028218487,0.0130673405,0.09526278,0.015099027,0.03330664,0.015541615,-0.041209955,-0.01944567,0.009326659,-0.030237954,-0.006100001,0.058242895,0.098538585,-0.008024437,0.0007265922,-0.012407228,-0.093833745,-0.07809156,-0.09587971,0.07873575,-0.029824529,0.0217137,-0.006205664,0.025367504,-0.05338853,-0.016532796,0.062672794,0.065370984,0.07052927,-0.037468333,-0.014535814,0.01427228,0.058125436,-0.014272628,-0.056571968,-0.02453745,-0.016939905,-0.02127676,0.07557955,-0.036164537,0.03283544,0.040026493,0.029005187,-0.013180712,0.020015398,0.010615696,0.082611054,-0.009457093,0.00876754,0.016362492,0.03021339,-0.026559891,-3.5104943e-08,0.038899828,-0.038163494,0.06308301,-0.06885716,0.00046381156,0.03349602,-0.07144307,-0.00076973013,0.13323227,-0.014923499,-0.0061889812,0.054207243,-0.006671968,0.02094828,0.080334924,0.0471751,-0.062369026,-0.00043986848,-0.00987816,-0.044219755,-0.038462985,-0.05181733,-0.049319014,0.12198176,0.03739445,-0.053471666,0.021970723,0.027543385,-0.022571325,-0.046894006,0.041616123,0.016448082,-0.03174101,-0.029895531,-0.060700543,-0.009287583,-0.012266966,-0.015787125,-0.060676392,0.07120033,0.007902463,-0.030130971,-0.08363716,0.009324315,0.08175017,0.045077406,-0.0096503,0.007849693,-0.019964792,-0.0325725,0.03824291,-0.013127074,-0.030004017,-0.05483382,-0.07997456,0.007958293,-0.036749974,-0.0415867,0.0002287637,0.010949534,0.044430036,-0.0064725075,0.16838744,-0.007861514 +3.6.3.22,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import Leu, Ile and Val.",384,1.0,-0.034319174,-0.05262929,-0.00040918234,-0.062247735,-0.08355984,0.021579783,0.0063670487,0.027350027,0.044103105,-0.06623677,0.012707045,-0.065375656,0.018841712,0.121146314,-0.04092614,-0.081322856,-0.07363177,-0.012623644,0.048256256,0.0060802926,0.060195554,0.07882775,-0.028192936,0.032764472,-0.041483153,0.008419284,0.038361575,0.0044102008,-0.029718958,-0.012906388,-0.121375225,0.011302267,0.0073346677,-0.010890679,0.06950835,0.050837096,-0.03920181,-0.0068279053,0.09819226,0.029076546,0.12148532,0.037385546,0.092213474,0.084852554,-0.07759737,-0.008093582,0.026281226,0.017646449,-0.024510615,-0.029965376,-0.034990214,0.0061287526,-0.0709069,0.08680459,-0.024938425,0.010117337,-0.023664787,0.0012082192,0.013147812,-0.036305085,-0.022669459,0.01288628,0.08164119,0.09700232,0.019124238,-0.0076445956,-0.034473345,-0.016185874,-0.01921075,-0.046780296,-0.08506331,-0.06956511,-0.049331006,0.09219425,0.05643715,-0.013443488,-0.017079964,0.014117233,-0.06840864,-0.049324878,-0.00813145,-0.04309055,-0.04153218,0.021075757,0.0120727075,-0.032652535,0.02796543,-0.003676596,0.03606338,0.015674395,-0.013015137,-0.04826148,0.016399259,-0.08628853,-0.04371958,-0.009555133,0.009337326,0.02825965,0.034674507,-0.0378565,0.03772159,0.05983331,0.032685637,-0.0060029053,0.012077491,0.009594916,0.015292964,0.011100707,-0.029698974,0.0073547913,0.0064574583,0.009469087,0.03243867,-0.06995092,-0.0114393765,0.050862994,-0.035586517,-0.0051853163,-0.083278544,0.023001019,-0.05354675,-0.15827776,0.031925518,-0.027563237,-0.03323743,0.03989117,-0.09083421,-1.3742348e-33,-0.059046563,-0.06549728,0.033227865,-0.045131147,-0.021925945,-0.029762613,-0.03123165,-0.004569923,-0.045457497,-0.10117281,-0.0075918743,-0.0052828705,-0.0027667861,0.079033434,-0.0020320811,0.025243295,-0.040028863,0.030546697,0.0654386,-0.012113012,0.076113254,0.07924911,0.022512704,-0.048857097,0.09197812,0.0120509695,-0.028453503,0.035613716,0.06229173,0.00033140974,0.032381732,-0.08756837,-0.1295874,-0.02612641,0.0016513849,-0.054563683,-0.04596727,-0.021322563,0.07574605,-0.06809433,-0.08369958,-0.007655323,-0.031345163,0.046751104,0.05322695,-0.041413084,-0.008179179,0.057088826,-0.048638865,0.035383172,0.034653563,-0.12691562,0.092571296,-0.090398,-0.014392909,-0.020352624,-0.0002963346,0.05867442,-0.06345031,0.04578275,0.09274326,0.12058864,-0.050149936,0.020519815,-0.013614063,0.05220345,-0.092454545,-0.104420684,0.06488652,0.071627244,-0.025626032,0.042124238,0.008770894,0.042505678,0.060497295,-0.0082088895,-0.04732038,-0.033182252,0.0034746884,0.05093156,-0.03667551,-0.09839317,0.033637438,0.042083427,-0.047589585,-0.054852482,0.0023002664,-0.012411332,0.008993413,-0.024620723,0.096707866,0.055832386,-0.04253489,0.12639768,0.047308855,-8.058217e-34,0.08345247,-0.046879277,0.10227009,-0.10577929,-0.049200043,0.013697645,0.017181821,-0.016242003,0.034475725,-0.053747788,0.019639753,0.026120037,-0.040555343,-0.050779354,0.006271632,-0.07958339,-0.0048332065,0.04195948,-0.0155726,0.012169458,0.01840067,0.0028069762,0.027095623,0.045381367,-0.05973526,0.008068339,-0.02944793,0.1357237,-0.016156945,0.025433965,-0.037769858,0.061006017,-0.007361341,-0.038588013,-0.1074275,0.011622822,0.01588884,0.055422686,-0.030193238,-0.019011866,0.057985034,0.07188602,-0.001917885,0.022405373,0.009670957,0.07974823,0.02246832,0.053624235,0.036216237,-0.025249923,-0.0061612106,0.020148804,-0.034848712,0.008420243,0.05435556,0.07888056,-0.015677273,0.021945186,-0.016112622,-0.095158726,-0.06399938,-0.087018445,0.07963577,-0.022810863,0.02026378,-0.0003857239,0.025583096,-0.06126451,-0.019243173,0.07493593,0.09189088,0.0625418,-0.040466223,-0.04249904,0.009069003,0.057076927,-0.03282766,-0.0630537,-0.038459357,-0.015474132,-0.009683971,0.05755143,-0.040721204,0.013778287,0.053938266,0.04612386,-0.036715087,-0.008575291,-0.0043516327,0.064250074,0.00708862,0.0064908992,0.015731169,0.028641388,-0.022908883,-2.9187813e-08,0.031973317,-0.03517399,0.04946358,-0.047711212,0.002638999,0.018077092,-0.07348987,-0.019065326,0.14586727,0.014687284,-0.019880125,0.05464516,-0.00010144577,0.01846471,0.09630146,0.052144594,-0.05939668,0.0145789515,-0.01771542,-0.033064988,-0.021693379,-0.07355264,-0.034766003,0.110034294,0.04248066,-0.055386305,-0.00082269893,0.014953327,-0.023847021,-0.057065375,0.04503417,-0.0034200107,-0.027661921,-0.02281305,-0.045508742,-0.011738157,0.00045378593,-0.016887542,-0.06531826,0.067111105,0.04785439,-0.061427068,-0.08696587,0.0027666718,0.081353575,0.0762176,-0.0064878273,0.04672215,-0.021395918,-0.031481735,0.039050538,-0.008839037,-0.020621834,-0.051030934,-0.06829607,0.001335876,-0.022805773,-0.052992325,0.0064444784,0.026166413,0.053078033,0.014413736,0.16454315,-0.027479451 +3.6.3.23,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports di- and oligopeptides.",384,1.0,-0.05079015,-0.06589483,0.012872877,-0.01759995,-0.05837432,0.00128274,0.054887023,0.04472557,0.073166355,-0.060543638,-0.008238813,-0.04009249,-0.0064608813,0.121281736,-0.013412265,-0.068228744,-0.058590546,-0.010436014,0.061740544,0.012551526,0.06484913,0.086365044,-0.037950326,0.0187064,-0.050444104,0.011097318,0.038568877,-0.015060701,-0.03527978,-0.025048558,-0.094847836,-0.013680326,0.0055801813,0.009733718,0.05730857,0.09100959,-0.03895536,-0.013215628,0.08413942,0.0090666795,0.14416623,0.058923706,0.08676211,0.10631321,-0.106008716,-0.007207158,0.041664906,0.03164217,0.0077046975,-0.031435825,-0.03815843,-0.00947292,-0.06007497,0.06941543,-0.021889934,0.041582458,-0.01038325,-0.002268303,-0.0033408755,-0.029468875,-0.02518585,0.019814093,0.08251719,0.08672253,0.007174894,-0.023072444,-0.028814834,0.005659148,-0.011480227,-0.052226685,-0.09011814,-0.026674848,-0.024592442,0.06252003,0.056561038,-0.016496345,-0.018942982,0.025665618,-0.072249226,-0.04182767,0.009765515,-0.05509833,-0.04499477,0.011176588,0.029409025,-0.02261889,0.02026823,-0.010193773,0.038551852,0.0018305355,-0.03516792,-0.044145573,0.020230917,-0.08204501,-0.07615475,-0.047531456,-0.006120225,0.053843018,0.03838532,-0.011738954,0.043831397,0.057938352,0.024674816,0.019160874,-0.01023545,-0.0047115614,0.03171542,0.013455742,-0.035546135,0.010908715,0.0055295727,0.0020623186,0.083395354,-0.06309478,-0.010430451,0.042547833,-0.060525566,-0.020028986,-0.07774694,0.018441876,-0.053158965,-0.14484912,0.050015498,-0.037483446,-0.053162776,0.06747209,-0.0698886,-1.5005676e-33,-0.049325168,-0.045958202,0.04945082,-0.03424719,-0.009265583,-0.013510374,-0.02904168,-0.04440599,-0.034511622,-0.095129855,-0.004923143,-0.029982207,-0.0068025226,0.07031409,0.011752481,0.026509805,-0.04960129,0.066802755,0.08377034,-0.008763431,0.062228903,0.06506047,0.00037603115,-0.021051984,0.08862229,0.0034318953,-0.04494894,0.0268524,0.09655707,-0.008684077,0.05117098,-0.06699363,-0.13503467,-0.023050448,0.01478852,-0.062035743,-0.053735085,-0.022296693,0.08272327,-0.09277649,-0.096200235,-0.025270432,-0.02973181,0.046735622,0.054678366,-0.035990264,-0.029675905,0.052863494,-0.048148375,0.030223507,0.04655364,-0.12919389,0.10897768,-0.095506534,-0.024014696,-0.014252444,0.004665399,0.0329991,-0.033923343,0.057784066,0.07675191,0.12470327,-0.06359687,-0.0012486029,-0.023265067,0.059855442,-0.053793624,-0.1097798,0.043324955,0.08148009,-0.015846826,0.018477475,0.0041653174,0.035986766,0.054211885,0.01050066,-0.062885545,-0.043945946,-0.006012541,0.033037003,-0.01565679,-0.069014564,0.030000094,0.033663314,-0.05445022,-0.029695697,-0.009506614,-0.026957236,0.022284621,-0.009770667,0.110004574,0.05272263,-0.0829312,0.10132378,0.04101216,4.4576554e-35,0.075127594,-0.018846408,0.09728307,-0.09569584,-0.06631102,0.013216332,-0.010631604,0.011606392,0.035602998,-0.06496139,0.0059909355,0.02833209,-0.05363525,-0.03551506,-0.010076493,-0.09865771,-0.017410455,0.059094172,-0.0065515046,0.0038445175,0.025285305,-0.013631151,0.024716655,0.044115163,-0.029583823,0.014302622,-0.030978143,0.12595257,0.0042016576,0.0070774145,-0.035299677,0.08184073,0.009571115,-0.043157235,-0.09829797,0.02835176,-0.0038179185,0.031733423,-0.02663908,-0.017341994,0.025796073,0.07710939,0.031995423,0.015733173,-0.0119704325,0.086778186,0.007914034,0.054995835,0.035850875,-0.013320984,-0.032754637,0.02181948,-0.029070174,-0.01480421,0.06327409,0.06888854,-0.028121162,0.020349074,0.008973572,-0.10554985,-0.046186626,-0.085791215,0.08221328,-0.015206652,0.0069047976,-0.012905652,0.027725857,-0.025898272,-0.010654074,0.064917095,0.032041848,0.07112581,-0.03771209,-0.029106906,0.016390635,0.055323582,-0.040706098,-0.044489495,-0.030960672,0.023745375,-0.025207005,0.055225316,-0.033048313,-0.0041102343,0.05110679,0.022561023,-0.013376725,0.01040097,0.009984666,0.0825206,-0.007854446,-0.0169234,0.031019509,0.041255884,-0.02281449,-3.0384175e-08,0.027077988,-0.030191937,0.067221396,-0.060270745,-0.015680013,0.025289636,-0.06219323,-0.013993659,0.11698153,0.011507974,-0.0128373755,0.06610473,0.006394402,0.016703393,0.07379045,0.085392274,-0.061714243,-0.02250018,-0.005048668,-0.032064766,-0.018932892,-0.05432665,-0.03422084,0.13832194,0.055280674,-0.067468815,-0.005328729,0.022499474,-0.04422161,-0.028984101,0.015355714,0.0022973064,-0.030968899,-0.0373973,-0.041202486,-0.012048899,-0.05132702,-0.003054143,-0.06608848,0.04469073,0.031919144,-0.03231986,-0.07974222,0.0015171746,0.059990983,0.073710635,-0.007592618,0.045866784,-0.04304736,-0.05384288,0.02889728,-0.005334094,-0.026190717,-0.045727704,-0.09875125,-0.012695299,-0.05113382,-0.035264753,-0.03552328,0.00333451,0.03144717,0.009172435,0.18212792,-0.01588473 +3.6.3.24,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Ni2+.",384,0.99999994,-0.051497776,-0.053399466,0.009198232,-0.030437874,-0.06585983,-0.004220323,0.055224244,0.0049838456,0.05431984,-0.06252946,-0.006074964,-0.055599593,-0.008923011,0.12918168,-0.05091292,-0.0767132,-0.050195985,-0.0007131619,0.07074359,-0.009170155,0.04526917,0.07742589,-0.055793148,-0.010363804,-0.0681047,0.031635594,0.029266085,-0.021837458,-0.016055565,-0.027010424,-0.09474166,-0.008988775,0.0063766837,-0.034102395,0.08564205,0.06426281,-0.019755369,0.014134399,0.053063154,-0.015116411,0.13310373,0.019493919,0.11689116,0.10371644,-0.077095084,0.016772727,0.06730701,0.028296465,0.006537874,-0.03431296,-0.05580005,-0.017261695,-0.020307206,0.066003814,0.030441435,0.03692344,-0.057459917,-0.0075929663,0.00411228,-0.019620301,0.013300831,0.013901568,0.08894637,0.047431264,0.06578839,-0.002879467,-0.017794006,-0.027312094,-0.017818075,-0.053055175,-0.085416,-0.042363726,-0.028841931,0.043441784,0.03973671,-0.024096793,-0.0050690025,-0.0051242243,-0.045994416,-0.058624107,-0.003856391,-0.015700208,-0.004658398,0.024922997,0.0027392916,-0.024544341,0.022518417,0.0060247644,0.01426431,0.022091525,-0.052468337,-0.024872815,0.026028603,-0.047554735,-0.08727922,-0.02850092,-0.04554087,0.070656195,0.0146069685,-0.019752393,0.069481075,0.07670488,0.032554243,0.0013550867,-0.008057409,-0.01274498,0.01936031,0.013883407,-0.0064691342,0.039578803,0.036596153,0.03830169,0.020125357,-0.057653308,0.0047412557,0.05266933,-0.060434863,0.010868364,-0.10135743,0.019303147,-0.044828456,-0.10636932,-0.007516732,-0.040923066,-0.07213269,0.056385256,-0.050973587,-1.9378608e-33,-0.06342541,-0.043972638,0.017135713,-0.02449077,-0.0017353524,-0.05004566,-0.07419383,-0.05969843,-0.028559944,-0.10397987,0.0074530183,-0.045076136,-0.006475297,0.048734628,0.00070923596,0.03537868,-0.051096756,0.042215385,0.104615286,0.011225224,0.07701018,0.076298274,-0.02374094,-0.03623455,0.11056891,0.02460512,-0.028742531,-0.0022332636,0.09856423,-0.016096003,0.050078567,-0.10074321,-0.116772585,-0.019988224,0.039750893,-0.08250549,-0.021127049,0.016836215,0.06024347,-0.06381385,-0.10262628,0.022988126,-0.047316846,0.0752701,0.049915586,-0.04112901,-0.02039254,0.073157445,-0.021269785,0.019275296,0.037438042,-0.14747438,0.110549256,-0.07837947,-0.021963961,-0.0071468875,0.01089821,0.0609849,-0.020434743,0.0037214498,0.09391809,0.092619926,-0.02873047,0.00895832,-0.013841432,0.064845204,-0.064638376,-0.11988146,0.09712746,0.084861055,-0.040986296,0.043600537,0.038098674,0.043520752,0.058103528,-0.035045654,-0.04902762,-0.06032947,0.035214,0.06164159,-0.022527754,-0.06428421,0.02777966,0.0014137307,-0.04481529,-0.053765792,-0.06035261,-0.016496459,0.021731362,-0.02976933,0.111164,0.04057359,-0.068741284,0.07040997,0.056387775,2.5632095e-34,0.0953851,-0.04230633,0.07004227,-0.103211574,-0.07701098,0.017939135,-0.024550734,-0.031177476,0.013389276,-0.03722784,0.03906159,0.030586658,-0.04550736,0.015456724,0.014668568,-0.10092505,-0.020916432,0.07175353,-8.879445e-05,-0.012122678,0.023256764,0.008311526,-0.011609473,0.039951067,-0.04616847,0.044726618,-0.044669658,0.11949197,0.03228478,0.007214162,-0.026726529,0.059079237,-0.021491906,-0.06666773,-0.06452455,0.020219233,0.02750245,0.036615193,-0.07658617,-0.028717496,0.04734621,0.088269286,0.03905319,0.060344372,-0.012357314,0.076627426,0.0019419432,0.029485084,0.005959784,-0.055291224,-0.010785315,0.033142272,-0.06410416,-0.00041310143,0.04837355,0.07040557,-0.012912773,0.051702,0.025981847,-0.08730376,-0.07846466,-0.109023236,0.07326477,-0.040244885,-0.0076700454,-0.030758036,0.023619272,-0.026067015,0.014685875,0.06724572,0.038174883,0.08807772,0.00058101997,-0.017768785,-0.010519526,0.053326026,0.016251361,-0.04742843,-0.01995089,-0.02243707,-0.03091015,0.06522179,-0.03643182,-0.006989916,0.058698054,0.036133356,0.0077068703,0.022542652,-0.00652538,0.031463955,0.012550905,-0.009976022,-0.036743753,0.014457585,-0.1015389,-2.9433354e-08,0.023083044,-0.035196986,0.041777097,-0.06408998,0.0043910337,0.06636032,-0.075601034,0.0073132557,0.14109957,0.00078050076,-0.009716828,0.06400716,0.01109067,-0.002983206,0.06962076,0.070299916,-0.037157718,-0.041189983,-0.017596118,-0.02636342,-0.020156616,-0.03047096,-0.06851983,0.11544573,0.022434734,-0.05080897,-0.0038346166,-0.0062260292,-0.057097368,-0.07363097,0.02043898,0.02626393,-0.008936392,-0.011820389,-0.044720795,-0.0011456115,0.0025494348,0.015505537,-0.053058676,0.027202787,0.021956028,-0.043360326,-0.06440154,0.004054329,0.0574174,0.056552365,-0.0040239715,0.019924676,-0.052175846,-0.032079056,0.018575817,-0.032870427,-0.010126393,-0.028862929,-0.09000523,0.023031255,-0.023588732,-0.046355963,-0.017243536,0.039960414,0.055296212,-0.00043331413,0.123315886,0.006540411 +3.6.3.25,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports sulfate and thiosulfate anions.",384,1.0,-0.06506183,-0.066183314,-0.0011930523,-0.036562204,-0.10873752,0.032782577,0.03604219,0.042337462,0.06431125,-0.041628383,-0.0067070294,-0.033434153,0.004136235,0.10031282,-0.05888378,-0.05074233,-0.05585583,-0.005661435,0.058622357,-0.022109853,0.07167706,0.07726745,-0.06687816,0.02268708,-0.05150775,0.04136162,0.022593565,-0.013461214,-0.059310745,-0.030190771,-0.13184987,0.0062196255,0.000495543,-0.003712227,0.044673927,0.11822412,-0.047032014,-0.0061044875,0.0628739,-0.02706594,0.116273254,0.047550496,0.07900563,0.095453575,-0.095337726,-0.02302707,0.050199028,0.03842703,0.004263556,-0.04069432,-0.051555887,0.0034399247,-0.054041617,0.06198876,-0.04398912,0.011976415,-0.019846126,0.027462943,-0.008007155,-0.049693506,-0.039201595,0.010267439,0.066858545,0.07083057,0.03189453,-0.018210825,-0.017480323,-0.017377563,-0.032446384,-0.057686534,-0.11703683,-0.05391929,-0.029904358,0.090851046,0.053747438,-0.0130945,-0.019439237,-0.019150663,-0.05011788,-0.037156712,0.013748511,-0.037295707,-0.042264134,0.035826407,0.015244066,-0.04785705,0.032689095,-0.009054346,0.054415874,0.027080828,-0.028564915,-0.036903765,0.018533634,-0.06635526,-0.0744773,-0.01203703,-0.0027169723,0.08627982,0.046313502,-0.029800542,0.07030772,0.06590227,0.028187321,0.0072982814,0.022699675,0.0012866838,0.011693493,0.029595487,-0.000592493,0.008496596,-0.028406883,0.012288629,0.040344313,-0.07337468,-0.024175346,0.091779016,-0.04627788,-0.015746675,-0.09440658,0.0041298643,-0.0468384,-0.12990817,0.0041394928,-0.035150964,-0.010459953,0.030606218,-0.11255754,-1.4734616e-33,-0.01846265,-0.016528703,0.06600121,-0.027685454,-0.05330117,-0.031341117,-0.038918875,0.0072071017,-0.015592106,-0.07299348,-0.018954696,-0.022367576,-0.019380538,0.03765903,-0.0070542702,0.030599618,-0.04683988,0.052169908,0.075016096,-0.022296356,0.028088177,0.072082475,-0.006838089,-0.058868375,0.072823726,0.012184016,-0.009331623,0.03182068,0.061970882,-0.0039094063,0.05663975,-0.07883145,-0.12112693,-0.034177132,0.035580438,-0.07105412,-0.056141283,0.026711605,0.06958098,-0.07362011,-0.08602088,0.0013464285,-0.027231677,0.037586942,0.031057583,-0.066817865,-0.05182884,0.056506604,-0.030731674,0.049937814,0.04122052,-0.12820111,0.12634926,-0.06987425,-0.019482262,-0.003397076,0.013044715,0.042848427,-0.058852285,0.054709844,0.10560187,0.10218702,-0.047626033,0.0038242757,-0.02858877,0.04246636,-0.0635371,-0.07773526,0.0612309,0.093432344,-0.0365025,0.040256437,0.032392807,0.050475832,0.031992584,0.008390745,-0.021868933,-0.047164638,0.005288879,0.021230225,-0.038837332,-0.0889715,0.031232994,0.047720198,-0.08645787,-0.031187302,-0.010748884,-0.00094480027,0.008392021,-0.020617625,0.09600015,0.037631996,-0.06436173,0.09616764,0.0426204,-6.963959e-34,0.088001005,-0.013827551,0.05911598,-0.11815838,-0.048963174,-0.004438614,0.029918661,0.017901784,0.013904619,-0.042820096,0.0042242208,0.0454552,-0.03480837,-0.042867918,-0.0056439666,-0.046503104,0.030950785,0.022796279,-0.03184942,0.0031636138,0.016624164,0.02576879,0.029514238,0.060981747,-0.071007535,0.013299809,-0.013116003,0.09536802,0.015718663,0.05094147,-0.009349535,0.038750283,0.024343869,-0.070525296,-0.1022896,0.0028043932,0.02052421,0.035965215,-0.031190317,0.011967326,0.061562095,0.044633094,0.034683168,0.04942919,0.018271975,0.075710855,0.010206081,0.056731395,0.036200788,-0.02632917,-0.0011358316,0.010742887,-0.002783946,9.8192824e-05,0.055447854,0.0837117,-0.039192785,0.01146472,-0.009735176,-0.093355,-0.07728605,-0.09587043,0.06412568,-0.062840536,-0.022226801,-0.009455197,-0.011516688,-0.094445266,-0.004096707,0.061527807,0.050822824,0.069511645,-0.05830198,-0.052108943,0.008049171,0.012763822,-0.0073354417,-0.038759682,-0.039460506,0.012592115,-0.03214391,0.10437144,-0.02041264,-0.01850314,0.060118683,0.018701103,-0.034065053,0.009162942,-0.008372975,0.057198852,0.0070498195,0.00908183,-0.0064792945,0.032289572,-0.06992674,-2.9312679e-08,0.017279558,-0.02433953,0.05671458,-0.029833991,-0.011593822,0.066448525,-0.03497786,0.019067813,0.12793155,0.02566477,-0.024304323,0.08274634,0.01669046,0.019605992,0.088765845,0.05439807,-0.0608229,-0.0061306655,-0.033837657,-0.039945066,-0.03188066,-0.07002504,-0.05667929,0.12121562,0.056614697,-0.0492365,-0.011266078,-0.03240551,-0.052177425,-0.02927991,0.03695004,0.031801198,-0.038048938,-0.043955445,-0.027372379,0.0068196403,0.0013042577,-0.0076751723,-0.06228248,0.040241923,0.03315848,-0.0020093308,-0.09414034,0.04179242,0.083933376,0.06245399,-0.005652024,0.06082523,-0.031393744,-0.021029755,0.03424668,-0.0013759756,-0.04728139,-0.059090238,-0.06273129,-0.009062786,-0.007142565,-0.049259048,-0.00673203,0.011784482,0.089009486,-0.017231623,0.15149155,-0.019915864 +3.6.3.26,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports NO3-, NO2- and OCN-.",384,0.99999994,-0.053955358,-0.074717276,-0.010171288,-0.02688265,-0.0666026,-0.0018824248,0.04345744,0.011011264,0.083994806,-0.08262043,0.02862308,-0.044470016,-0.01480253,0.1173567,-0.06011322,-0.062084112,-0.0391021,-0.017039975,0.08322558,-0.004732087,0.048271563,0.083646715,-0.021739861,0.0033339155,-0.042020164,0.013551326,0.01653568,-0.0077761463,-0.016685972,-0.065582715,-0.078108,-0.00042323876,0.023463042,0.0031954166,0.08504773,0.04227112,-0.020099616,-0.011530613,0.049095057,0.048978,0.12745346,0.041636854,0.088332705,0.0940855,-0.08131714,0.004345314,0.044331428,0.015421595,-0.002915212,-0.018595716,-0.037487518,-0.011876085,-0.057449404,0.043228496,0.0037364706,0.0146402065,-0.05381299,-0.02172929,-0.010587448,-0.009360033,0.0016135136,0.024511008,0.07525166,0.06295448,0.0698624,0.008429599,-0.029854126,-0.036259282,-0.008760086,-0.0373701,-0.100570485,-0.05151632,-0.0090059005,0.029976595,0.016465077,-0.02114032,-0.0127595505,0.036446687,-0.04709473,-0.029527947,-0.008911535,-0.026385909,-0.0688639,0.025289673,-0.02260417,-0.035702854,-0.0048967074,0.030235458,0.04171393,0.040631354,-0.063854374,-0.03573533,0.028784007,-0.06827728,-0.072744496,-0.02231824,-0.0057184077,0.095564105,0.016052065,-0.025946012,0.05310598,0.061850596,0.055558495,0.0038683338,0.0037660557,0.0035580792,0.023461884,-0.0043712915,0.018918136,0.02167972,-0.020178799,0.026605371,0.032196473,-0.09021366,-0.03704455,0.027820291,-0.06336811,-0.02030254,-0.10496341,0.048585918,-0.047129694,-0.16275315,-0.0029597562,-0.023418335,-0.03861045,0.07873193,-0.0744453,-1.8824429e-33,-0.051682528,-0.048246358,0.057598628,-0.03876419,0.012429616,-0.024049312,-0.026902404,-0.046151113,-0.03403741,-0.11375132,-0.00094961235,-0.031088905,0.0067670387,0.027786098,0.009007156,0.014062056,-0.048948526,0.013531086,0.07355935,0.01983764,0.07991282,0.062932745,-0.024758017,-0.021758512,0.09105557,0.021629779,-0.037157193,-0.005650259,0.0695588,-0.024973191,0.03178268,-0.08449609,-0.09210805,-0.026994096,0.055265393,-0.08660282,-0.054442007,0.0011349026,0.0846537,-0.065869845,-0.10396964,-0.004656238,-0.036908858,0.059639275,0.047249693,-0.031553205,-0.025717553,0.09337513,-0.048249036,0.03970283,0.05571444,-0.12452764,0.09278278,-0.056257468,0.018441632,-0.021317163,-0.02801365,0.07286046,-0.06466472,-0.00020961117,0.100499384,0.06744551,-0.058636602,-0.010958619,-0.02427939,0.04645519,-0.059078567,-0.095313706,0.09806889,0.06120746,-0.029698988,0.043005634,0.010340413,0.07214327,0.048489567,0.019162904,-0.056596227,-0.047311325,0.02224009,0.02640364,-0.0089257825,-0.057055846,0.041286897,0.015132428,-0.06691883,-0.023682028,0.00029638427,0.008780155,0.010611241,-0.039305523,0.118189566,0.026237339,-0.061938364,0.06963473,0.043066904,4.5455926e-34,0.11512892,-0.04899576,0.08915114,-0.105882525,-0.07722894,0.023232093,-0.019568315,0.0032625245,0.01714819,-0.024517355,0.034603972,0.026599733,-0.02028876,-0.052173413,0.034988478,-0.08222453,-0.020798149,0.08970839,-0.020691594,0.0029959728,0.027535811,0.008392727,-0.031420197,0.058731876,-0.06437408,0.059453033,-0.03849399,0.123948194,0.015694136,0.022111632,-0.04471346,0.052979246,0.01614964,-0.058547873,-0.055181425,0.007859386,0.04637506,0.07506958,-0.037360407,-0.058356967,0.04451813,0.081561096,0.05049174,0.04466202,-0.021469176,0.08060664,-0.01019593,0.025549933,0.020335866,-0.029970547,-0.008692602,0.018812483,-0.052370418,0.0007372255,0.05755058,0.094041266,-0.007676988,0.027505483,0.026635678,-0.106223874,-0.058165826,-0.1102985,0.08942665,-0.0021837268,-0.0006470787,-0.01300326,0.00078768533,-0.022255877,-0.0030359428,0.03206625,0.009261211,0.09010844,-0.025536327,-0.028816916,0.011505037,0.056554154,-0.021368973,-0.04233474,-0.045648072,8.347607e-05,-0.04903707,0.042925972,-0.03806919,-0.011611719,0.06736063,0.0582967,0.026762567,-0.00072466856,0.0105340015,0.060831547,0.016476713,0.004336324,-0.023259152,0.028886646,-0.058669336,-2.9563386e-08,0.026869481,-0.06506362,0.06258026,-0.05758732,-0.008709303,0.056721874,-0.05806077,-0.0001343624,0.12482117,0.023491675,0.037631117,0.054179985,-0.011940032,0.003642353,0.08254198,0.049591012,-0.03682309,-0.03088726,-0.0060625686,-0.043809652,-0.04177596,-0.042191323,-0.0375571,0.1345741,0.052440844,-0.046926826,0.00373744,0.045972593,-0.027940439,-0.06993844,0.032126613,-0.01848458,0.0006463713,-0.033235062,-0.09112886,-0.029622179,0.0122743985,-0.010326611,-0.051383205,0.050044842,0.012391411,-0.026874056,-0.075417146,0.015666028,0.069581866,0.0579268,-0.0046017873,0.02099255,-0.043815415,-0.036164258,0.029368399,-0.021918066,-0.046680477,-0.039231896,-0.0974481,-0.03185667,-0.023167614,-0.014079336,-0.032412343,0.030912438,0.04225074,-0.0064080474,0.1465152,-0.0036453344 +3.6.3.27,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports phosphate anions.",384,0.99999994,-0.069698684,-0.07494884,0.013846557,-0.036274,-0.111073576,0.029851537,0.0663674,0.02452415,0.061413642,-0.030467164,0.0035695937,-0.03326004,0.020434914,0.11808245,-0.058270566,-0.07125537,-0.053960506,-0.015230813,0.064839214,-0.012304791,0.06350663,0.081081785,-0.042254087,0.01855792,-0.054518998,0.012394775,0.027091205,-0.027762983,-0.043603685,-0.028870644,-0.12811303,0.004553511,0.01871236,-0.002679018,0.060461957,0.104449764,-0.039130684,-0.0009091119,0.06778062,0.00455933,0.12444558,0.025526784,0.09588843,0.09121406,-0.096594654,-0.0023599712,0.04529008,0.025126807,-0.006034189,-0.035381272,-0.051216483,0.00336436,-0.055713728,0.020046713,-0.04348664,0.011797903,-0.0016577226,0.027916793,-0.0214226,-0.024578555,-0.02179841,-0.0029618077,0.07467509,0.09177673,0.029497785,-0.028526863,-0.0029798166,-0.017666606,-0.041630547,-0.06680934,-0.09494153,-0.05919922,-0.009437611,0.054389913,0.061944515,-0.013728202,-0.025555309,-0.002617422,-0.07363032,-0.022692569,0.0036788778,-0.057155557,-0.044175033,0.017804176,0.021246951,-0.044583954,0.018333023,-0.0051787687,0.030755676,0.025798095,-0.047509257,-0.036292303,0.025852425,-0.064158514,-0.06114941,-0.025656413,-0.0012251174,0.042972855,0.036514398,-0.050594304,0.04700714,0.07655547,0.036730062,0.014602581,0.034905896,-0.008802066,-0.018934008,0.0040184036,0.025812754,0.012191863,-0.018597063,0.020676717,0.049041677,-0.07407069,-0.0099597955,0.06649882,-0.0793068,0.0053362744,-0.074537106,0.0343911,-0.052683294,-0.15538615,-0.0047146743,-0.026142815,-0.032355946,0.031362046,-0.081283376,-1.8636927e-33,-0.047893617,-0.03749196,0.04659558,-0.008688172,-0.04698344,-0.022990488,-0.028785437,-0.039960213,-0.041010298,-0.10692359,0.008383853,-0.025599146,-0.007228377,0.049160965,-0.012800728,0.027971087,-0.05478971,0.0495271,0.06611916,-0.0021975671,0.059487984,0.07640285,-0.006802533,-0.026991168,0.09917111,0.005752561,-0.038429573,0.019097516,0.057166126,-0.008564198,0.034571476,-0.059751414,-0.13549484,-0.023228502,0.020001939,-0.103360504,-0.043891333,0.009203642,0.07451566,-0.07925062,-0.09924317,-0.00721239,-0.03473039,0.056716576,0.048497047,-0.038947728,-0.022727326,0.05854293,-0.03580557,0.046500582,0.04723568,-0.12169676,0.120239384,-0.06938318,-0.031312566,-0.01642848,0.0007033646,0.05853098,-0.043040045,0.059829175,0.11446739,0.11496275,-0.03445245,0.008203074,-0.027672881,0.0367995,-0.052879076,-0.10597526,0.074449725,0.09826213,-0.0034104802,0.03793258,0.031000167,0.054034583,0.043722585,0.00063152524,-0.023244768,-0.0356975,-0.0011041968,0.015369632,-0.019786919,-0.0832277,0.0473164,0.03815126,-0.07351558,-0.052624125,0.0009810142,-0.005041774,0.0184753,-0.044227708,0.13491958,0.05474611,-0.07399566,0.08422644,0.05031829,4.9494276e-35,0.10581721,-0.008010171,0.059726883,-0.10083354,-0.054759767,-0.0070655746,0.03985057,0.00906714,0.022508357,-0.04593602,0.006662952,0.041525193,-0.042486712,-0.036502264,-0.024717635,-0.058994304,0.031246983,0.048032366,-0.013690113,0.01799373,0.015433618,0.0007530316,0.028522378,0.05278788,-0.07106344,0.015839169,-0.052790407,0.08795607,-0.019212058,0.022691354,-0.015381131,0.06305823,0.012649597,-0.06709061,-0.11251664,-0.0074185175,0.015586351,0.036407858,-0.038100276,-0.0041217958,0.06345943,0.077635564,0.038588338,0.02389409,0.0019462113,0.070294835,0.0272741,0.06029687,0.01758223,-0.03781397,-0.026793994,0.029768024,0.00783435,-0.028094288,0.048376452,0.07893204,-0.033178944,0.016630858,-0.0021735975,-0.08535976,-0.05801087,-0.08457088,0.08924955,-0.027601473,-0.012489744,0.0058654933,0.036356695,-0.06512264,0.0044502397,0.058124032,0.051720824,0.07890531,-0.04721258,-0.023916056,0.009498492,0.03303588,-0.014670172,-0.056984678,-0.031923413,0.0033073216,-0.03616177,0.085177235,-0.024812715,0.0037924817,0.062893875,0.029906657,-0.005153992,-0.017526928,0.004884131,0.05645579,0.011029433,-0.00013203695,0.012269707,0.026804687,-0.029443948,-2.8170627e-08,0.04144623,-0.027758593,0.057662178,-0.06030971,0.01926175,0.03200551,-0.044185214,0.0005044938,0.15713346,-0.002548145,-0.035035044,0.03999455,0.01433112,0.019902656,0.09500985,0.06802887,-0.055790007,-0.005155349,-0.02652417,-0.02089454,-0.0250093,-0.05668566,-0.06082711,0.113056876,0.051479872,-0.01743163,-0.012988601,-0.003222572,-0.038612317,-0.029156797,0.020263942,-0.0010853896,-0.03398329,-0.039616622,-0.04480154,-0.001692401,0.02084765,-0.0068765245,-0.06874184,0.046036936,0.017394783,-0.041627213,-0.059112858,0.025816303,0.07430905,0.08045506,-0.034737125,0.03490691,-0.012156077,-0.02973839,0.044741996,0.0005544676,-0.060887262,-0.04653879,-0.06866551,-0.019517569,-0.02280782,-0.039402504,-0.001757575,-0.0027648283,0.053468768,0.012056327,0.14394236,-0.03370362 +3.6.3.28,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports phosphonate and organophosphate anions.",384,0.99999994,-0.063275345,-0.06138886,0.0044599916,-0.04639762,-0.11254715,0.036598668,0.052413933,0.032877624,0.053837217,-0.033967756,-0.006098267,-0.058579978,0.013458678,0.11371241,-0.04204183,-0.06915988,-0.07270966,-0.022988327,0.06002608,0.004139915,0.04906527,0.08888189,-0.042032566,0.012111196,-0.037920535,0.018490708,0.024576442,-0.01539371,-0.038491834,-0.016295198,-0.11760141,0.005872857,0.036071714,-0.029145394,0.059463628,0.098017626,-0.029644605,-0.015423489,0.08091953,0.01105336,0.12074179,0.0453515,0.09816844,0.10148961,-0.10561325,0.0014589357,0.033603013,0.023339571,-0.008538327,-0.023812106,-0.033991393,-0.009141544,-0.04731168,0.05025898,-0.050190553,0.04013051,-0.0006252058,0.03170607,-0.012415062,-0.026492296,-0.018941542,-0.00292326,0.061083816,0.09102381,0.034685783,-0.019798001,-0.007856937,-0.033096258,-0.024853893,-0.060449317,-0.10349782,-0.067076065,-0.020114154,0.070699826,0.044308092,-0.00043541007,-0.009436414,-0.004027996,-0.06777043,-0.030919764,-0.0034484738,-0.057520457,-0.04771076,-0.0027579411,0.023031853,-0.037759773,0.009031832,-0.0015510846,0.024376908,0.022954175,-0.053612124,-0.04364752,0.026216103,-0.08297704,-0.06875497,-0.0063413572,-0.01403715,0.05791464,0.048137423,-0.045563083,0.06397141,0.0766372,0.03203093,-0.005291318,0.032110635,-0.010617226,-0.018688433,0.00094909116,0.0038111333,0.0022227287,-0.019879598,0.018278353,0.052680556,-0.07010167,0.001860906,0.06370708,-0.05866221,-0.005637687,-0.08696599,0.037673395,-0.045798622,-0.15339302,0.0019832249,-0.03231171,-0.03472048,0.032324754,-0.092084505,-4.6312875e-34,-0.04801682,-0.039609224,0.05669781,-0.03549393,-0.023721525,-0.025015825,-0.036459558,-0.019283338,-0.041607246,-0.10396729,0.016458694,-0.01949158,0.0002929234,0.048435554,0.0012827446,0.04017564,-0.05345278,0.066852935,0.06445603,-0.014828154,0.05744794,0.083214335,0.004084814,-0.019020403,0.110088445,0.008745834,-0.03437853,0.0036453493,0.064887315,-0.017890511,0.019779196,-0.069201335,-0.13001713,-0.035117894,0.023674857,-0.085310146,-0.044457257,0.0058466843,0.06362661,-0.0801788,-0.08632198,-0.013293834,-0.040858988,0.058653064,0.046883684,-0.03438076,-0.050525643,0.049905274,-0.029189859,0.03711744,0.052246884,-0.12638967,0.107941374,-0.051717814,-0.0095863715,-0.0045244615,0.0014619,0.044432975,-0.050745063,0.053519186,0.10426231,0.11631229,-0.04103519,0.019496197,-0.022788664,0.04558599,-0.06042074,-0.11905875,0.060703453,0.092214435,-0.0054531316,0.030981526,0.014935912,0.06501078,0.030701553,0.009077142,-0.03445758,-0.050834328,0.0030857364,0.020114183,-0.01656144,-0.075157076,0.05375102,0.030847784,-0.05931491,-0.068420455,-0.0011715799,-0.02279613,0.0211723,-0.045963112,0.112350814,0.048227843,-0.073912226,0.0909452,0.035476476,-1.5545939e-33,0.101129964,-0.019125652,0.06650599,-0.11860281,-0.04780103,0.02403149,0.024166627,0.009674291,0.01206342,-0.049429253,0.015068334,0.033507567,-0.026269358,-0.016331706,-0.024829939,-0.066494934,0.020256009,0.064735524,-0.006578069,0.014307756,0.03362677,0.008460054,0.03716057,0.07090507,-0.06844164,-0.0056566284,-0.05186326,0.091460586,-0.025761941,0.037813205,-0.037623484,0.063813716,-0.00032084834,-0.0773975,-0.09261028,0.019748999,0.018096156,0.03883278,-0.019118518,-0.010211829,0.058187682,0.08135167,0.03448155,0.013493999,-0.004641159,0.059543908,0.008780451,0.054867666,-0.005296952,-0.024392366,-0.01743028,0.017112989,0.0059796553,-0.019581528,0.05160158,0.08025405,-0.03513851,0.012678346,-0.007423354,-0.08593035,-0.06462801,-0.0869316,0.0704589,-0.031969674,-0.00047879195,0.010273615,0.043768924,-0.06677311,-0.008641663,0.060239177,0.06322604,0.08758425,-0.045145757,0.0018903404,0.0053283228,0.046949487,-0.015738588,-0.062506236,-0.02911808,-0.007161365,-0.023341546,0.0902673,-0.013415661,0.0051184483,0.048046578,0.023580046,-0.0019638392,-0.01838683,0.000361959,0.06303801,0.005369253,0.007526346,0.011516983,0.03625778,-0.02255042,-3.0415922e-08,0.04627418,-0.008431994,0.06459833,-0.07105957,0.007763128,0.03219838,-0.05154471,-0.018726235,0.14667726,-0.0024843842,-0.022863721,0.031243553,0.03207438,0.025491565,0.07167406,0.06498918,-0.062168576,0.003785682,-0.031814426,-0.037353605,-0.019583154,-0.049366076,-0.038077082,0.118681416,0.05236548,-0.03683168,-0.0014282891,0.017361727,-0.033258907,-0.023509866,0.0054145264,0.009579058,-0.050693907,-0.03582436,-0.05931099,-0.0065089446,0.0075780754,-0.022891972,-0.0908903,0.05009341,0.008764608,-0.036171157,-0.0854649,0.0243682,0.079725996,0.06321593,-0.018267358,0.044564903,-0.011798317,-0.032568943,0.044855736,0.011000957,-0.035717573,-0.06747773,-0.08192185,0.0022392753,-0.038325492,-0.0246566,-0.02365775,0.0057905973,0.041090783,0.006853683,0.1556054,-0.029451018 +3.6.3.29,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports molybdate anions.",384,1.0,-0.05010117,-0.066582575,-0.0036874074,-0.0159804,-0.09877263,0.020080745,0.044137433,0.023632472,0.055715032,-0.07591124,0.00994367,-0.022080135,0.03325691,0.119877525,-0.06397557,-0.042598024,-0.03478156,-0.02829835,0.059419665,0.012941183,0.043587714,0.07154795,-0.031167602,0.0053745164,-0.05873937,0.00070973154,0.0005798833,-0.024495635,-0.023515578,-0.043044265,-0.09723967,0.05575672,0.030296538,-0.011801097,0.070080355,0.097781286,-0.017635249,0.005950321,0.07648943,0.029335223,0.10364574,0.058303893,0.114487454,0.08590762,-0.0967877,-0.0068959394,0.05632358,0.011777921,-0.031654097,-0.011783881,-0.032317076,-0.019650644,-0.073155716,0.038666796,-0.027338361,0.016191155,-0.024832113,0.042862885,-0.011612747,-0.034198783,-0.043815028,0.039551597,0.09178599,0.100263685,0.012031891,-0.045666683,-2.0383148e-05,-0.027271697,-0.029487122,-0.07565441,-0.103425436,-0.060075123,-0.014244433,0.06475379,0.040088937,-0.0038294666,0.0018532552,0.0024662311,-0.04149192,-0.04996322,-0.018186664,-0.06906517,-0.03783035,0.0007571438,0.023971302,-0.050438233,0.011614904,-0.014275088,0.032392286,0.011020724,-0.026919447,-0.03732416,0.016408965,-0.05906739,-0.074874386,-0.036459345,0.026578592,0.041263543,0.011722347,-0.015188836,0.045152094,0.077576004,0.00966743,0.03444835,0.02624739,-0.018529115,-0.017013393,-0.002523048,0.013234431,0.018953586,-0.00849379,0.041115265,0.077123836,-0.06418535,0.014699291,0.041979257,-0.07984972,0.033778455,-0.058895115,0.0072022453,-0.055035815,-0.12743692,-0.0035867726,-0.041228767,-0.05039586,0.07043405,-0.047333505,-1.13126105e-33,-0.011602394,-0.050189473,0.04234002,-0.010864854,-0.026262939,-0.035303082,-0.02797619,-0.043254215,-0.037101705,-0.1161105,0.013896748,-0.04313851,0.00071302714,0.053437885,0.011324995,0.022810325,-0.061202258,0.010909409,0.06562967,-5.787835e-05,0.045087915,0.05544096,-0.0039074253,-0.033157267,0.114265375,-0.0033402182,-0.018351363,0.032165907,0.064741164,0.0027810545,0.02174539,-0.055405144,-0.13347718,-0.034402326,0.022797402,-0.07998415,-0.05669607,-0.0013349623,0.07670563,-0.06916999,-0.09940017,-0.022333091,-0.051034756,0.024652742,0.05334947,-0.018340081,-0.0358072,0.077967994,-0.021621944,0.02572411,0.03318532,-0.13288912,0.096439146,-0.069383375,-0.043662623,0.0044526593,-0.009599044,0.05933058,-0.051971026,0.07323547,0.107927755,0.12633204,-0.0119431745,0.0027335617,-0.047232814,0.041732375,-0.07102814,-0.111991905,0.07435069,0.09105564,-0.014047287,0.03817884,0.048283752,0.050187856,0.034663267,-0.017458795,0.020245563,-0.069050424,0.015938558,0.016058845,0.00062445854,-0.07941547,0.064737864,0.031961456,-0.057895076,-0.055767193,-0.027289443,-0.0017628826,0.014422616,-0.022746975,0.10978211,0.05487698,-0.057996806,0.07967642,0.032603838,-2.3643604e-34,0.1093396,-0.021638902,0.077014975,-0.10034312,-0.058555793,-0.0037222186,0.0070004403,0.0064864266,0.008152519,-0.05749459,-0.0020760824,0.0446542,-0.046046983,-0.0452602,-0.018119235,-0.066795535,0.034671187,0.044850517,-0.024117514,0.010642937,0.015859215,-0.008252962,-0.004182128,0.032525856,-0.051538926,0.028618466,-0.05545209,0.098846465,-0.0005422243,0.019297691,-0.021805985,0.05736686,-0.010818034,-0.095903516,-0.09751265,0.008589747,0.016436521,0.0376816,-0.046631604,-0.023379143,0.040842246,0.08095316,0.03518435,0.040293332,0.033713087,0.1020903,0.00017538272,0.02706256,0.041862622,-0.018912781,-0.0364955,-0.008102371,0.009643423,-0.008772516,0.04865374,0.06965572,-0.033765946,-0.00861586,0.008053621,-0.092323355,-0.05831687,-0.07725415,0.08830261,-0.036535736,-0.010935186,0.01960297,0.037908666,-0.054323584,0.014083441,0.028721567,0.05778954,0.079506435,-0.060188543,-0.012962792,0.022615151,0.026930185,-0.024816839,-0.04967654,-0.041826624,-0.013291145,-0.041636635,0.09666198,-0.015394791,-0.0018249989,0.063659154,0.029377058,-0.02264007,-0.002420522,0.033459373,0.05317172,-0.004966402,-0.008755153,-0.009172564,0.019813465,-0.023149576,-2.935113e-08,0.02300217,-0.053015593,0.050047003,-0.06905638,0.018469281,0.06870995,-0.030927766,0.01150034,0.14932339,-0.02361142,-0.0060869395,0.06857089,0.027680958,0.0022066268,0.07440859,0.09644051,-0.074599236,-0.02376115,-0.020862773,0.002169069,-0.016857186,-0.060498398,-0.042926874,0.14289032,0.04618765,-0.033027276,-0.032694235,0.043456655,-0.045760438,-0.026045311,0.011170077,0.009724514,-0.010103562,-0.02997335,-0.047617793,-0.019925002,0.02080865,-0.012545828,-0.073466405,0.060173012,0.019944293,-0.03448028,-0.04595621,0.030423779,0.09272721,0.044340424,-0.033857066,0.037672415,-0.015875062,-0.026361672,0.041927837,0.0019211723,-0.045909993,-0.019637916,-0.09417931,-0.027784312,-0.043445144,-0.06434151,-0.014302969,-0.006533168,0.02049389,-0.00030604922,0.14826298,-0.034167565 +3.6.3.30,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports ferric cations.",384,1.0,0.0005181859,-0.080868505,-0.046275686,0.0016200036,-0.06524061,0.036710016,0.04085794,0.034536485,0.071812086,-0.05996277,-0.020599704,-0.060429662,-0.011720212,0.09984437,-0.046868093,-0.11697933,-0.06573601,-0.006531857,0.065937325,0.03381047,0.054480936,0.07198393,-0.011510716,0.003962172,-0.08200608,0.021320207,0.035087775,0.020768227,-0.056621287,-0.04838814,-0.10813123,0.035651613,0.0149036525,0.0073522558,0.038799305,0.07146363,-0.042692583,-0.011329288,0.10514699,0.005477424,0.09246737,-0.0048438455,0.08073456,0.08357161,-0.12671563,-0.009931932,0.046505623,0.010644989,-0.0009298823,-0.018041419,-0.044422533,0.0042006383,-0.07640335,0.059043717,-0.017729266,0.018482719,0.005358468,-0.014958556,-0.010770722,-0.019714288,-0.026150703,0.0077576577,0.051403284,0.10259166,0.026666118,-0.022959854,-0.043000493,-0.024319265,-0.0087168375,-0.06523859,-0.084374115,-0.04057703,-0.021963693,0.042202994,0.05308132,0.014118627,0.019976854,0.009831456,-0.043250836,-0.028960092,-0.006513205,-0.029579924,-0.050918248,0.0011290666,0.021633128,-0.021611914,0.02156927,-0.033883646,0.031969633,0.034995545,0.0035799835,-0.02243697,0.025540749,-0.07148728,-0.07760334,-0.046995614,0.010198206,0.0541002,0.04930492,-0.046826933,0.03052771,0.08565158,0.06460991,0.028565696,0.013612936,-0.020010665,0.01726328,0.0522922,-0.017191242,-0.00013466868,-0.020982241,0.01731209,0.025160376,-0.082549244,0.0072445506,0.057604756,-0.027398573,-0.01007271,-0.09363337,0.015152399,-0.039179627,-0.1317447,-0.0065640123,-0.040800024,-0.046895955,0.031140871,-0.094242774,-1.4695523e-33,-0.04259839,-0.039184306,0.02122864,-0.028309165,-0.028587032,-0.016670233,-0.049398106,-0.06955162,-0.018987624,-0.058152713,-0.011024207,0.004663116,0.002219024,0.0345928,-0.022965312,0.0029233005,-0.075774975,0.01107503,0.07358733,-0.0053017004,0.09845639,0.083924584,0.04616337,-0.06123854,0.08816845,0.014216941,-0.034904275,0.03268219,0.06743345,0.00038422202,0.04389553,-0.07400623,-0.124662265,-0.055455633,0.024741301,-0.07718068,-0.054169882,0.005032744,0.09310864,-0.069932,-0.0733608,0.0013681644,-0.03561626,0.03999438,0.060656976,-0.049498674,-0.024222985,0.10732838,-0.045854714,0.057727966,0.06780775,-0.14418459,0.11092061,-0.05524058,-0.015647316,-0.027617954,-0.010867327,0.024752028,-0.07046892,0.08713003,0.09380007,0.12384949,0.0062056994,0.013665846,-0.004662014,0.019771984,-0.05454855,-0.08139436,0.07739745,0.0920908,-0.016100725,0.05453878,0.04643719,0.01998937,0.074144945,-0.008297711,-0.046781052,-0.080891885,-0.0021615615,0.025802191,-0.015082522,-0.06936084,0.041090105,0.040993486,-0.059176307,-0.030358449,-0.046567377,-0.0068500126,-0.031465694,-0.028862072,0.10600649,0.05626103,-0.057751406,0.09805774,0.06679008,-4.0068856e-34,0.10533228,-0.04904352,0.08032335,-0.10308315,-0.06403471,0.010715606,0.02941209,-0.015428419,0.004647208,-0.024259703,0.022901915,0.04998951,-0.029302517,-0.045946855,-0.004870052,-0.08233848,-0.019926436,0.04312388,-0.00070001266,0.017733205,0.002962569,-0.0019746807,-0.005315501,0.038241353,-0.025009852,0.007278759,-0.05664187,0.089866005,-0.015511581,-0.0029784536,0.010992799,0.034766547,0.01065262,-0.054896895,-0.09346991,-0.0124146575,0.028968934,0.056970533,-0.011519338,-0.016089544,0.027713468,0.080121264,0.019567052,0.01677011,0.0030932978,0.0577372,0.013951526,0.03804159,0.047176484,0.015275931,-0.04853075,-0.0062271673,-0.050241463,-0.002769398,0.060718622,0.09142296,0.010787973,0.011081321,0.0016159054,-0.07143003,-0.05758215,-0.073931694,0.10393367,-0.036304034,0.02525611,-0.011573663,0.03402055,-0.04227079,0.02024117,0.074110076,0.08291262,0.07990274,-0.059546277,-0.037971977,0.028818185,0.0537116,-0.007113406,-0.031118827,-0.0486145,0.019188229,-0.013687169,0.0704307,-0.041686,-0.004821575,0.053524632,0.012590242,0.004417893,-0.019077828,-0.014508545,0.05189668,0.020417051,-0.022711726,0.036700003,-0.0063968683,-0.03030752,-2.8542008e-08,-0.0006473398,-0.020636301,0.0044548786,-0.06479454,0.019903407,0.04086607,-0.08546373,-0.033512704,0.12084965,-0.006192697,-0.007918333,0.07971782,0.029653005,0.026471717,0.10698135,0.048902035,-0.062956534,-0.005701421,-0.011639431,-0.020241423,-0.0403283,-0.061562177,-0.07983432,0.11718516,0.061859965,-0.065158695,-0.028915953,0.015913093,-0.045487564,-0.020816745,0.042827554,0.0012619412,-0.013889793,-0.037575725,-0.01716739,0.0020239137,-0.005228312,-0.023515379,-0.08453889,0.060593553,0.034947768,-0.049946014,-0.0606296,0.005641115,0.037347887,0.08730274,-0.035444405,0.049929917,-0.020818206,-0.0098867575,0.04697134,0.013180511,-0.02938934,-0.049603812,-0.074736446,0.042060893,-0.04795269,-0.04513799,0.0025431565,0.01410157,0.031370487,0.0038160738,0.13852002,-0.04210498 +3.6.3.31,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports putrescine and spermidine.",384,1.0,-0.04528885,-0.06676276,-0.016482696,-0.055117678,-0.093318984,0.053705025,0.020729106,0.046524365,0.06603735,-0.031943716,0.007581995,-0.028932335,0.014493308,0.14030719,-0.013496141,-0.072340414,-0.0579513,-0.029374909,0.0685721,0.01028005,0.07907199,0.09379678,-0.057661545,0.013349308,-0.029254666,0.0059876023,0.01939562,-0.0030310466,-0.044411533,0.00076632015,-0.13393599,0.017703446,-0.02555538,-0.022508116,0.039669707,0.08132772,-0.049645334,0.014440484,0.09403813,0.005841533,0.12281295,0.0008193675,0.08271674,0.10325142,-0.108572565,0.011184697,0.10675367,0.036828168,0.021536514,-0.011303478,-0.038078494,-0.007916618,-0.04195586,0.043996893,0.0013316318,-0.0069225216,-0.014549102,0.010777529,-0.006615701,-0.018358357,-0.03385783,0.0017622468,0.06663306,0.07691164,0.045153603,-0.016306056,-0.040167484,0.0020325417,-0.013191985,-0.06363851,-0.0647079,-0.067665145,-0.014282188,0.08301881,0.031942435,-0.016537575,-0.021377752,0.01982426,-0.0475229,-0.047216125,-0.013449254,-0.08170785,-0.08280591,0.013889476,-0.004435472,-0.020908162,0.030725632,0.008539118,0.028411658,0.020255243,-0.05514478,-0.048908602,0.017280951,-0.074404374,-0.07540901,-0.03204943,-0.014801529,0.04373128,0.019178731,-0.035158638,0.054143917,0.081731774,0.04784176,0.0071006194,0.0027794724,-0.016052265,0.0071255993,0.022435853,-0.017538652,0.009197461,-0.00582613,0.02266194,0.037359305,-0.05391292,-0.012134296,0.053344384,-0.04571949,-0.01358933,-0.0851551,0.0024276187,-0.07086499,-0.117580235,0.030753592,-0.016162617,-0.023640668,0.022486761,-0.05815569,-1.431786e-33,-0.050060965,-0.053050596,0.053027205,-0.006699928,-0.008151191,0.008929471,-0.02133046,-0.027671633,-0.0060569113,-0.11742346,-0.008202733,-0.053331893,0.0008290825,0.06279043,-0.014031066,0.0024989473,-0.050786838,0.019063778,0.06691044,-0.00088644074,0.06902165,0.09060047,-0.01242365,-0.03752904,0.08093808,0.007967517,-0.018978927,0.02388412,0.071788885,-0.015491243,0.037426915,-0.058921956,-0.13354544,-0.058018707,0.019601723,-0.06921957,-0.061609592,-0.017266365,0.09432463,-0.06852612,-0.071266964,-0.032484777,-0.052493528,0.05925821,0.036873814,-0.06724413,-0.027549706,0.07750321,-0.047559414,0.043025758,0.05519593,-0.1399124,0.13385347,-0.07836092,-0.056069545,-0.019565288,-0.0084601715,0.03702391,-0.0768932,0.048271976,0.10162984,0.098272465,-0.03590664,0.034133773,-0.016812377,0.03636087,-0.1022492,-0.10027783,0.054769184,0.103564784,-0.010479875,0.053485177,0.031322036,0.0067844545,0.044306897,0.00020332752,-0.083483174,-0.033092774,0.0084074475,0.02318591,-0.009354594,-0.06690386,0.011407643,0.029873695,-0.066407315,-0.039437845,0.0018475942,-0.026279459,0.02480945,-0.036288906,0.102852374,0.021931866,-0.03359792,0.0979302,0.07170195,-3.1540945e-34,0.07156548,-0.059131466,0.11130883,-0.08696166,-0.009539126,0.011757425,0.030059662,0.008335455,-0.014958198,-0.054665215,0.00026997313,0.027960105,-0.032874443,-0.046655443,-0.017077629,-0.069591306,-0.014251128,0.03894309,0.0045139184,-0.0042326185,0.00035798608,-0.0053696674,0.028476946,0.043431096,-0.04875065,0.0062169447,-0.036080096,0.10215612,-0.004229538,0.032317746,-0.012451294,0.06770542,-0.0015049136,-0.015354983,-0.0786033,0.017906252,0.014320869,0.068908274,-0.01815544,-0.03428008,0.030209411,0.07605327,-0.009591307,0.0479638,0.002823348,0.101768374,0.009710323,0.043906637,0.026296327,-0.018958904,-0.014403721,-0.00094445905,-0.038461927,-0.018534545,0.064937934,0.072493374,-0.036590848,0.0055718706,0.022701718,-0.088406764,-0.08169163,-0.08123035,0.06434833,-0.0053123655,0.0030271849,-0.033072796,-0.002354171,-0.034377243,0.012451204,0.07746397,0.08015363,0.050964575,-0.024278956,-0.029995583,0.022692673,0.0384719,-0.0075177383,-0.041135266,-0.027588662,0.0062486883,-0.028660106,0.050865356,-0.04373534,0.04088562,0.055044778,0.03915669,0.017278044,0.019265488,-0.02011231,0.06577481,-0.029473493,0.025589636,0.018454826,0.048556924,-0.022386696,-3.030256e-08,0.049031273,-0.03465589,0.064514235,-0.047466308,-0.0032969357,0.04302605,-0.07999798,-0.0067544184,0.13569647,-0.018541541,-0.044906605,0.023492502,0.017252384,0.023573238,0.092688866,0.059085123,-0.03369034,0.005349592,-0.024311602,-0.023691272,-0.025832837,-0.06726923,-0.06006477,0.13603958,0.034140438,-0.011039255,-0.0034160619,0.02940022,-0.038552955,-0.055319104,0.040265128,-0.01672854,-0.050354958,-0.034443647,-0.06219866,0.008066424,0.00212251,0.0073455954,-0.05275206,0.057953335,0.03370494,-0.069022834,-0.061373256,0.025841791,0.09118704,0.058041587,-0.010108196,0.029338388,-0.039229307,-0.032526527,0.0063846977,0.027780762,-0.03550352,-0.05216,-0.060763817,0.001524454,-0.055142272,-0.042821303,-0.008301934,0.02587956,0.04220821,0.038210817,0.15396328,-0.01856268 +3.6.3.32,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports betaine and glycine.",384,1.0,-0.0528198,-0.08213311,-0.01666602,-0.026322607,-0.08628441,0.04846896,0.02814778,0.021597845,0.06096954,-0.056827184,0.020210883,0.00039100673,0.022318803,0.13572933,-0.040775284,-0.09412369,-0.05198377,-0.016122386,0.04783365,0.0070534083,0.017837051,0.0866045,-0.05199674,0.025074983,-0.029456988,0.013970978,0.03284202,-0.023566913,-0.030265812,-0.0056724865,-0.122290306,-0.01718392,-0.0024165525,0.02043099,0.014225523,0.08847781,-0.053358983,-0.018845376,0.08794895,0.029548263,0.10120837,0.028873859,0.08083876,0.08402054,-0.067988165,0.011799146,0.05116377,0.03129431,0.04203205,-0.03232162,-0.026892617,-0.021823188,-0.055244014,0.05189391,-0.009852097,0.020927021,-0.030584702,-0.001874527,0.019013986,0.0043479027,-0.041961867,0.02179567,0.07884987,0.07483887,0.025439152,-0.024852915,-0.052012995,-0.027066194,-0.01150803,-0.062712625,-0.081811026,-0.064548284,-0.058037072,0.047280017,0.028060688,-0.03662896,-0.03400931,0.03262634,-0.059392825,-0.039318163,-0.012317008,-0.08644509,-0.05405896,-0.0070812753,0.0070396904,0.0013688542,0.022139078,0.016094929,0.019882292,0.018871678,-0.02161475,-0.04227219,0.012766789,-0.0725461,-0.06025066,-0.05776867,0.026040452,0.028110417,0.03505784,-0.028887106,0.01995109,0.07194947,0.04280694,0.021321766,0.010042111,-0.0033039653,0.037110586,0.014688026,-0.02628568,0.010313834,-0.011386836,0.029941851,0.05874701,-0.039441034,-0.006560683,0.064689174,-0.038713645,0.008080256,-0.08164211,0.027154906,-0.043551777,-0.13045162,0.0144622,-0.0260693,-0.041317288,0.07138961,-0.07780768,-1.4230235e-33,-0.037285637,-0.01358193,0.055160362,-0.03261974,-0.0077627846,-0.016456299,-0.061187174,-0.039121706,0.0037405929,-0.096138924,0.008815201,-0.005028308,-0.014294766,0.07509073,0.025326403,0.057634193,-0.05642014,0.040094566,0.110559404,-0.014129377,0.040852226,0.044184264,0.0056770714,-0.06315587,0.114515595,0.010129218,-0.024560012,0.03888027,0.0770343,-0.0032502175,0.018886015,-0.08458794,-0.114112206,-0.022741066,0.011162812,-0.057388272,-0.06312682,-0.025428638,0.08593033,-0.08633144,-0.051075764,-0.02805237,-0.04104339,0.060317874,0.03262188,-0.025155958,-0.0175959,0.044208396,-0.047163907,0.029264577,0.054848433,-0.1293077,0.10662786,-0.07160746,-0.013284633,0.008015891,0.007289198,0.04326033,-0.05835805,0.07760312,0.071521476,0.11874019,-0.026626976,0.000667482,-0.0054528518,0.048449706,-0.1047467,-0.09296038,0.039201614,0.05904896,-0.009251716,0.028371483,0.0508315,0.02923365,0.03173316,0.0070037856,-0.03360332,-0.059293903,0.0041770083,-0.009671947,-0.040244207,-0.050644673,0.029540814,0.035117548,-0.04189184,-0.025646955,0.030606003,-0.041675836,0.013461185,-0.04095485,0.10433625,0.05785512,-0.053564657,0.09856214,0.045353625,-2.6419633e-34,0.09623151,-0.06408166,0.09261451,-0.11347504,-0.033658702,-0.021195404,-0.007133039,-0.044004902,0.030474978,-0.048910934,-0.012560138,0.031671792,-0.047736686,-0.042795382,-0.014528526,-0.084722646,0.008516745,0.035891242,-0.02671222,-0.022168038,0.027694559,-0.0014402748,0.04076241,0.035928044,-0.06550148,0.006612268,-0.026226941,0.13742444,0.011401167,0.03208064,-0.023360742,0.066044025,0.009260088,-0.07437622,-0.08910028,0.022316843,0.011402469,0.06405718,0.0036139265,-0.03439145,0.065616146,0.07829438,-0.009052718,0.028995253,0.030185038,0.11936251,0.04708016,0.020682162,0.0048124455,-0.03655772,-0.004208858,-0.015099151,-0.025728911,0.020657107,0.05822887,0.08305956,-0.031152036,0.053636782,0.015718577,-0.10767375,-0.038782768,-0.081538096,0.0639472,-0.010290887,0.0082504945,-0.029297542,0.028392563,-0.048877392,0.022902718,0.08036244,0.03817011,0.04927641,-0.035226036,0.014376661,0.02981095,0.058445055,-0.04847425,-0.05864421,-0.037567057,0.0052528796,-0.04097556,0.09931466,-0.06904686,0.01959046,0.059652258,0.018294342,-0.0047242055,0.05329157,-0.004970154,0.04491905,-0.0029217047,0.012035502,0.008636458,0.039287627,-0.019423723,-2.7645665e-08,0.041112218,-0.029470228,0.07842723,-0.073359735,-0.007304548,0.046405762,-0.043540467,-0.0038249525,0.11920202,-0.014170164,-0.059215784,0.051960036,0.011036202,0.002815136,0.055169478,0.08864789,-0.091323175,-0.013082586,-0.0053642136,-0.031749014,-0.02440286,-0.024496611,-0.031390652,0.1283144,0.00032156255,-0.060162056,0.006497643,0.03236122,-0.08521063,-0.03811627,0.038593017,0.027727436,-0.031067936,-0.058734607,-0.07100801,-0.02059655,0.0005453808,0.017233772,-0.019638196,0.04666263,0.020260546,-0.0518433,-0.08765474,0.01083056,0.061771877,0.07097509,0.0014379547,0.03653977,-0.010202192,-0.05682802,0.047282934,0.0062199216,-0.04102347,-0.06881603,-0.08734645,0.015684363,-0.07556703,-0.0496058,-0.01484461,0.0024017824,0.025510814,-0.004816071,0.15440498,-0.023044473 +3.6.3.33,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports cobalamin derivatives.",384,0.99999994,-0.043163784,-0.0426027,-0.032675333,-0.06329208,-0.09267401,0.039535243,0.017136613,0.028514996,0.052061364,-0.05649728,0.021779476,-0.07470969,0.026760716,0.11150153,-0.016400103,-0.094187565,-0.033062734,-0.026178733,0.043310642,-0.026440836,0.015394595,0.097029164,-0.05379218,0.032852422,-0.05284705,0.0104976185,0.03255829,-0.008070755,-0.026805706,0.0047098594,-0.12395836,0.003580647,0.0075083147,0.016601158,0.010814821,0.10239705,-0.025270805,-0.008669444,0.11464621,0.03027638,0.1157933,0.06436621,0.09069603,0.09070215,-0.06970273,0.00771662,0.04418687,0.031259183,-0.0054581235,-0.016671564,-0.0518212,-0.004322977,-0.06686328,0.064492926,-0.02302977,0.026015107,-0.021854145,0.014593962,0.026526045,-0.014418191,-0.028371751,-0.02888754,0.085534684,0.08238495,0.03830484,-0.012319418,-0.009358565,-0.013042334,0.021777883,-0.05258239,-0.057602994,-0.054129135,-0.04454138,0.028158745,0.017648375,0.015212639,-0.020946857,-0.0031183201,-0.078474626,-0.038041327,-0.0063872663,-0.042529397,-0.028528348,0.012920776,0.023987446,-0.045612093,-0.0154284155,0.0053297896,0.042680517,0.040170774,-0.028142432,-0.041042693,0.049299326,-0.055957396,-0.1012654,-0.009067199,0.00062846916,0.07244461,0.014148945,-0.056761295,0.026107403,0.06299185,0.03340601,0.039600335,0.03660456,-0.034923382,0.05978553,0.053195912,-0.027733473,0.012818516,-0.015541111,0.022847252,0.03668938,-0.083414465,-0.009450897,0.074677914,-0.019362075,0.008028312,-0.10649939,0.040283665,-0.020426026,-0.11864159,0.015663043,-0.06729583,-0.037916206,0.027888717,-0.052044064,-1.828524e-33,-0.039337453,-0.03882818,0.044170953,-0.029388318,-0.011783699,-0.029792061,-0.0586169,0.0024457218,-0.025620967,-0.11762737,0.018135846,0.010597033,-0.018735135,0.067213394,-0.02043898,0.020734327,-0.059240717,0.007826892,0.09005183,0.0066698827,0.06561826,0.06647139,0.0053622327,-0.003269671,0.062913164,0.009741326,0.0025162045,0.051861968,0.05108375,0.00080617965,-0.00077157374,-0.07564195,-0.11936451,-0.04682897,0.019195288,-0.064758606,-0.080365285,0.006057314,0.060438197,-0.062329013,-0.073244214,-0.034708936,-0.07625782,0.056397256,0.04308173,-0.047938183,-0.036671385,0.07147504,-0.050120346,0.04251795,0.038540866,-0.10847315,0.10639142,-0.027455287,-0.021645175,-0.013249209,0.009507113,0.0378213,-0.072470106,0.06264409,0.09735248,0.11255815,-0.022611417,0.045930423,-0.031639103,0.042454332,-0.06974639,-0.12498302,0.06570094,0.06327038,-0.00071924226,0.01087761,0.004838745,0.06933462,0.058347095,-0.0118993865,-0.03674454,-0.078427985,0.015124821,0.0057275705,-0.028140029,-0.08709142,0.049149968,0.04432462,-0.07988049,-0.0266747,0.011648184,-0.014895522,0.0007214108,-0.061206833,0.066421784,0.08001711,-0.009131041,0.10686713,0.05106713,1.1755001e-34,0.092041135,-0.03637306,0.101698175,-0.10747262,-0.06240434,0.013532704,0.01581081,-0.0424444,0.037154987,-0.034591846,0.018787041,0.011066978,-0.070401534,-0.016791448,-0.027237514,-0.045818195,-0.009785835,0.054609746,-0.017067172,-0.010429375,-0.003036371,-0.0051778867,0.016868789,0.03341329,-0.06166381,0.036336236,-0.008121562,0.103984386,-0.0076245726,0.066204116,-0.040819585,0.05368598,0.010185847,-0.043451812,-0.1052001,0.043955423,0.02003563,0.043449093,-0.026602633,-0.032233536,0.033688504,0.08148032,0.029962996,0.0265656,0.009415526,0.1086923,0.028088063,0.05430034,0.001407134,-0.008206766,0.0012260524,0.035539925,-0.053060822,0.0062252474,0.051952936,0.07785947,-0.026582027,0.00937807,0.012383161,-0.13571247,-0.051721577,-0.07982365,0.05011253,-0.028799316,0.005355325,-0.009075672,0.06498735,-0.04322514,0.0034596568,0.08547464,0.049800232,0.06325605,-0.025216635,-0.02337292,-0.0029327678,0.061691426,-0.039460998,-0.049656015,-0.052126586,-0.01952366,-0.035015576,0.03834287,-0.006222055,0.006664543,0.031773087,-0.0008828638,-0.021438178,0.006965705,0.0019142953,0.095102146,-0.029145574,-0.016835852,0.0038780796,0.014749329,0.0027965668,-2.8801342e-08,0.04366236,-0.052792124,0.039844338,-0.052800033,0.009497759,0.07469099,-0.107869014,-0.027846225,0.1623811,0.014868996,-0.029145816,0.048438568,0.0078374185,0.0558038,0.021974748,0.04951059,-0.049888294,0.007367011,-0.011845968,-0.01867866,-0.0500894,-0.042624682,-0.028932095,0.08983454,0.054041717,-0.058721967,-0.028895339,0.027271738,-0.0492742,-0.053427674,0.03600014,0.011512379,-0.0038786156,-0.045072097,-0.052075498,-0.0026729307,0.0059664473,-0.006391104,-0.061396033,0.06858742,-0.009158394,-0.04977848,-0.102157764,0.024581878,0.072286405,0.045277134,-0.0064903093,0.059779935,-0.046514608,-0.02652438,0.056565598,-0.0023144167,-0.0066805515,-0.048059214,-0.0625405,0.0009096901,-0.049182303,-0.073297225,-0.026453555,-0.00041223946,0.024862327,0.015061997,0.14041907,-0.05878693 +3.6.3.34,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores.",384,0.99999994,-0.029957056,-0.07833258,-0.017372405,0.0039080004,-0.068056576,0.016872456,0.037072197,0.02379472,0.034621064,-0.07108103,-0.025227353,-0.07302568,-0.016555103,0.11061957,-0.03442128,-0.095175155,-0.043656766,-0.010311339,0.05692973,0.042530917,0.032989964,0.059238777,-0.033930127,0.0113639785,-0.10390814,0.009201321,0.053895075,0.011135922,-0.054338638,-0.0400352,-0.12875779,0.019248908,0.023607032,-8.537437e-06,0.0422757,0.099898785,-0.02808653,-0.014425147,0.091883995,0.0158045,0.10683662,0.030666875,0.10164845,0.09690331,-0.10451704,-0.04368053,0.051843703,0.016711414,0.027133359,-0.011881987,-0.0449495,0.008820923,-0.061715104,0.09986312,-0.018274067,0.008568303,0.016161628,-0.0060085505,-0.017794726,-0.028274486,-0.030818593,0.003183316,0.08526389,0.077578515,0.0047827223,-0.037767064,-0.031558555,-0.019249035,-0.027363634,-0.0512832,-0.09222762,-0.0496558,-0.028038133,0.056787577,0.028257225,-0.0027959784,0.012790982,0.039941993,-0.04230597,-0.041639514,-0.0021781027,-0.0546121,-0.052544177,0.021370366,0.021111859,-0.012414224,0.004362659,0.0011215498,0.022763893,0.043153185,-0.035811506,-0.030128406,0.018920299,-0.08870928,-0.07718571,-0.0558251,-0.00052622263,0.027718997,0.042187586,-0.02687606,0.024392946,0.08269498,0.055565875,0.00083548436,0.019077064,-0.019496446,0.007867184,0.053923886,0.0029609515,0.012308494,-0.0113189835,0.033024527,0.0625685,-0.04440047,0.0116273,0.03734559,-0.04073278,-0.014305005,-0.060159374,0.032693807,-0.03188223,-0.14160341,0.029856296,-0.03527849,-0.053129904,0.02195031,-0.09681353,-8.27756e-34,-0.04371871,-0.045993004,0.038984902,-0.037345864,-0.02961858,-0.0028693178,-0.053132802,-0.03856773,-0.023734309,-0.07106817,-0.020517671,-0.011960328,0.02716626,0.060892712,-0.016944269,-0.021524088,-0.08302075,0.025744183,0.060850006,-0.015627608,0.07531647,0.07507662,0.0064695748,-0.056334,0.09245517,0.039425943,-0.05297525,0.030703764,0.062370155,-0.008881079,0.032589376,-0.07648725,-0.12127081,-0.053223792,0.032812487,-0.054977577,-0.025799064,-0.01544923,0.07379328,-0.09929595,-0.081993975,-0.014825481,-0.053411093,0.027989544,0.051636994,-0.053388797,-0.025338326,0.0761178,-0.023942882,0.05306362,0.044141762,-0.14444605,0.10312423,-0.09535335,-0.033785567,-0.01719188,0.0042974465,0.04372981,-0.025098901,0.066251926,0.101928435,0.120437816,-0.032463893,0.011589905,-0.02387215,0.037902903,-0.046511795,-0.09078042,0.082084365,0.088543214,-0.022916839,0.061883092,0.042131837,0.02135345,0.050409093,0.0036018742,-0.06734678,-0.06303707,0.026668161,0.045372657,-0.004577468,-0.07548079,0.032050848,0.030578343,-0.044355445,-0.013933479,-0.032493915,-0.010878166,0.0053261756,-0.029465474,0.11698454,0.048085283,-0.068214074,0.082434885,0.057463467,-1.1562912e-33,0.07961141,-0.05093063,0.08776814,-0.108743005,-0.038600773,0.004703076,0.011512933,0.007286556,0.0057959454,-0.037496403,0.026420845,0.02629438,-0.0426532,-0.0562308,0.0009861967,-0.06355446,-0.025341187,0.024450807,0.016053637,-0.009076816,0.01066526,-0.00052563334,0.031492647,0.04496457,-0.03416037,0.0033720904,-0.045661695,0.11498041,-0.01898643,0.02040262,-0.028474474,0.058682505,0.011559446,-0.05817314,-0.08860453,-0.011825788,-0.011711396,0.045383707,0.003563039,-0.030028764,0.047418583,0.07156435,0.02720542,0.04343999,-0.027910806,0.100122705,-0.011189168,0.033194687,0.044088744,0.019570692,-0.042331036,0.0036815545,-0.04458911,-0.011895102,0.05666028,0.08457568,-0.0027446353,0.020317206,-0.00783879,-0.04341166,-0.068124555,-0.07850455,0.09233922,-0.017289868,0.011863448,0.012023828,0.024262901,-0.017479299,0.013466344,0.06404906,0.09049808,0.05775315,-0.020905143,-0.0091793295,0.028511122,0.037397955,-0.018313998,-0.037347794,-0.057398174,0.037326057,0.006632015,0.07101893,-0.06343304,0.01567335,0.035237532,-0.009032848,-0.026832232,-0.026171664,-0.019152287,0.050227795,0.0046682674,-0.007580118,0.02652419,0.005319158,-0.04680908,-3.407406e-08,-0.0043418715,-0.05172491,0.06926453,-0.05864959,0.021723451,0.045314662,-0.08418143,-0.030864794,0.12228029,-0.0150101585,-0.0026255315,0.06777848,0.013617034,0.025013555,0.07314831,0.064280525,-0.06154355,0.0023146076,-8.813739e-06,-0.014205342,-0.025977068,-0.05631216,-0.047405183,0.11204227,0.06773348,-0.046409104,-0.04174399,0.012194081,-0.033197537,-0.038978737,0.017718714,0.00782508,-0.018733218,-0.014067114,-0.070357695,0.002828325,-0.04042177,-0.012861754,-0.104337834,0.06067038,0.04070844,-0.030437648,-0.065082185,-0.011088631,0.05587941,0.08223555,-0.034130268,0.065258235,-0.01832025,-0.048596784,0.04285432,0.0001592631,-0.013058238,-0.045739163,-0.074434064,0.04569299,-0.034895502,-0.059262786,0.012515562,0.031959012,0.029867355,0.015807647,0.17467654,-0.019117776 +3.6.3.35,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Mn2+, Zn2+ and iron chelates.",384,1.0,-0.037717875,-0.065113604,-0.016326422,0.008537532,-0.030969333,0.013185892,0.06348709,0.04020878,0.038447026,-0.056455016,-0.0018873049,-0.03568269,0.038955968,0.09629215,-0.040962633,-0.07325121,-0.062186733,-0.008970692,0.047223095,0.022105316,0.058870256,0.07058438,-0.009598629,-0.0046120756,-0.055839762,0.009360453,0.04354434,-0.016697004,-0.05900345,0.010345517,-0.108038016,0.011846441,0.02351943,-0.019007364,0.07697337,0.077984884,-0.024551827,-0.009914389,0.06356504,0.010305275,0.11049438,0.04304548,0.12682185,0.06036006,-0.08176966,-0.00070415926,0.1046103,-0.009540326,-0.01939223,0.030960217,-0.042370804,-0.009879865,-0.0684812,0.075283974,-0.0069236304,0.024648678,-0.04265206,0.010316691,-0.02414363,-0.030037995,-0.004187768,-0.02447113,0.04798007,0.068374515,0.046563912,0.0055142497,-0.038775686,-0.02304489,-0.009516437,-0.07846475,-0.066848025,-0.030416066,-0.040436685,0.047029775,0.02432877,-0.013761014,0.03214524,-0.018053222,-0.04283966,-0.04579805,-0.02448675,-0.038834717,-0.02173042,0.005659933,0.017938608,0.007718667,0.030207,0.0155967865,0.0067926985,0.031332437,-0.033996448,-0.005654318,0.0380892,-0.071981184,-0.090912044,-0.028490113,-0.0007280664,0.079113014,0.044148326,-0.0061763804,0.07317393,0.07885918,0.019627921,-0.01844229,0.04917152,0.012484554,0.029726574,0.052654307,-0.035017874,0.032749966,0.03455828,0.024211558,0.04262358,-0.059186198,0.012726937,0.06940225,-0.015408835,-0.0132652335,-0.10538417,0.0413939,-0.022614911,-0.119490035,-0.0052506565,-0.05148321,-0.03724532,0.049529932,-0.08570112,-8.296325e-34,-0.07759609,-0.022784138,0.02600563,-0.02409842,-0.007427396,-0.015079682,-0.039024096,-0.056332078,-0.009080162,-0.09012596,-0.016814472,-0.031423036,0.007234996,0.050534032,-0.0405151,-0.009499194,-0.057057112,0.009358068,0.1108004,0.01227783,0.07133338,0.066391245,0.015549352,-0.053847715,0.074126124,0.03965065,-0.013466645,0.030868303,0.05077691,-0.01871641,0.033547513,-0.10929869,-0.14835896,-0.04580387,0.06328952,-0.07474453,-0.04857891,0.0006662265,0.062643796,-0.09054996,-0.06758959,-0.009883286,-0.066191494,0.068590686,0.054247927,-0.053276446,-0.04661899,0.072387904,-0.03356966,0.028663369,0.03869809,-0.12248835,0.1050643,-0.05612607,-0.041713923,-0.011623052,0.005183663,0.054114264,-0.048966315,0.058886807,0.09260689,0.10550181,-0.027577821,0.043535016,-0.006203951,0.04259376,-0.0746277,-0.109790646,0.079589225,0.09977078,-0.01986925,0.009616455,0.050969504,0.050359588,0.04791156,-0.0015048565,-0.06740926,-0.06460703,0.01891116,0.054400783,-0.030202767,-0.0781118,0.025196167,0.034497492,-0.09969275,-0.04838593,-0.019937325,-0.033601966,0.021243056,-0.037795294,0.102091104,0.040287632,-0.05370235,0.07978943,0.03462783,-7.796211e-34,0.0700764,-0.012942259,0.103736036,-0.11581914,-0.09129546,-0.0064630993,-0.014029239,-0.03903088,0.0026868107,-0.0347969,0.053996913,0.017137071,-0.018159034,-0.033536952,0.0035727355,-0.0670437,-0.007868359,0.053406615,0.032726966,0.013809335,0.03693751,0.00486954,0.014362319,0.05335956,-0.049162656,0.01498066,-0.02507478,0.099128984,0.024546372,0.03483869,-0.033640034,0.04088654,0.013491575,-0.08810553,-0.08910699,-0.014296919,0.024611562,0.04705566,-0.007304819,-0.024334718,0.04585021,0.014421548,0.022344276,0.059878025,-0.02195153,0.044037245,-0.011883004,0.02404318,0.013326537,0.00058219535,-0.023382455,0.011303539,-0.069971755,-0.021495033,0.09058577,0.075567186,-0.008606586,0.030863617,0.017279124,-0.08478634,-0.08748123,-0.098819524,0.08859651,-0.031506766,0.01623502,0.013907994,0.019011654,-0.05904138,0.0019927842,0.095167674,0.07268928,0.078051426,-0.014481242,-0.046499245,-0.019317368,0.042380042,-0.01546124,-0.028023178,-0.047847487,0.014069344,-0.0115718385,0.05377649,-0.028198859,-0.0009480903,0.050078392,-0.01177298,-0.0047059637,-0.0015381812,-0.02234456,0.04067836,0.0047079897,-0.046609513,0.0063661425,-0.009789429,-0.08998222,-3.1921576e-08,-0.027428834,-0.05140632,0.03912926,-0.061743446,-0.013804484,0.03423182,-0.086303204,-0.034687217,0.12990554,0.014307333,-0.0011768482,0.07386043,0.011827558,0.0045634843,0.08723843,0.058305196,-0.05321477,0.014196283,-0.02071628,-0.02079139,-0.033124994,-0.043757524,-0.05772851,0.1304494,0.04893985,-0.044323422,-0.018894348,0.029857283,-0.016151462,-0.05878506,0.019486504,0.0042312983,0.0027960124,-0.030733243,-0.060425155,-0.003184054,-0.0053230026,-0.008702737,-0.086705565,0.049326107,0.0030047707,-0.035348818,-0.078903995,0.028523687,0.044994693,0.0395603,-0.009935199,0.059555054,-0.024973495,-0.036979128,0.04170847,-0.026618615,-0.02067972,-0.069765784,-0.08002787,0.047309004,-0.024412153,-0.034202423,-0.019509,0.055940848,0.039228275,0.00075377495,0.13389055,-0.06743422 +3.6.3.36,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports taurine.",384,1.0,-0.016916115,-0.06597153,0.030217236,-0.047394324,-0.06341071,0.046104528,0.054257613,0.04753521,0.075149976,-0.067891054,-0.0080362065,-0.035998862,0.00962194,0.115236655,-0.0062223407,-0.05097208,-0.05359825,-0.03819708,0.10387434,0.0025839184,0.015710205,0.043988872,-0.03192936,0.034652397,-0.0426811,0.020106377,0.043722972,-0.015629718,-0.065701194,0.00051741867,-0.10213366,-0.023658508,-0.005859176,-0.0133835515,0.004475971,0.06621627,-0.067277454,0.034217842,0.07596938,-1.985601e-05,0.15086757,0.047883406,0.08378536,0.072222635,-0.08097593,-0.008861351,0.053241033,0.0059455535,0.01223745,-0.0006077684,-0.04299706,0.007731563,-0.06099646,0.062889986,-0.0035616336,0.09960764,-0.040617622,-0.07894772,0.0027815048,-0.034398932,-0.04306253,-0.0060656583,0.017049488,0.049526617,0.037671253,-0.02488561,-0.021703253,0.038078852,0.04110962,-0.040606886,-0.07059615,-0.02127306,-0.023685837,0.06837607,0.030488055,-0.008672983,-0.053852614,0.010968967,-0.043820042,-0.0756571,-0.008961134,-0.04565977,-0.06447497,-0.0032454017,0.09275694,-0.038161643,0.040864654,-0.027412003,0.033098474,-0.0038869146,-0.013164567,-0.014063177,-0.009823338,-0.08140414,-0.029884944,-0.019273654,0.027001869,0.063670285,0.011008942,-0.035608962,0.040195238,0.05905358,0.028730609,-0.010865771,0.013049464,-0.012852503,0.0025196834,0.0007587347,-0.0041122227,0.00031114914,-0.01914028,-0.015584275,0.011419637,-0.049155165,0.06441057,0.08357278,-0.05149888,-0.030895073,-0.094314404,0.041035827,-0.07109528,-0.12271257,0.031183505,-0.054450467,-0.030481828,0.08193637,-0.050979484,-2.0382716e-33,-0.055468876,-0.008978509,0.03641193,-0.015448566,0.009040932,-0.023563836,-0.063899264,-0.07214387,-0.027720155,-0.07848934,0.02646196,-0.050443918,-0.044422496,0.06431566,0.04001125,0.0069396626,-0.020542689,0.05774759,0.09290831,-0.02461143,0.017566,0.105073795,-0.016055316,-0.04713722,0.06772278,0.008474957,-0.057125438,0.0040783426,0.030499894,0.01402262,0.024954554,-0.008676319,-0.13220465,-0.023775132,0.011221187,-0.061829735,-0.082895435,-0.03665483,0.08315162,-0.050537724,-0.04759283,-0.051507004,-0.011976693,0.08314728,0.008564214,-0.038820215,0.0036345713,0.021782266,-0.043699536,0.045261636,0.051918056,-0.13338847,0.12162318,-0.124969624,-0.038031016,-0.033152293,0.03295514,0.014735655,-0.044485062,0.06544979,0.065167,0.12058025,-0.03022351,0.03340227,-0.0026425838,0.019677605,-0.05545685,-0.12381061,0.04325826,0.09627286,7.816344e-05,0.024532376,0.01429746,0.043103755,0.068209276,0.028376384,-0.054146085,0.0019613504,-0.012310848,-0.01992124,-0.03809539,-0.0734331,0.022050736,0.05308894,-0.037688833,-0.021383435,0.020484297,-0.027029352,0.04090753,-0.017524835,0.11428512,0.0799683,-0.06478938,0.121407755,0.017466301,8.817806e-34,0.062626004,-0.041404434,0.054296874,-0.11304068,-0.07464554,0.06466203,-0.0015889468,0.0116557,0.045840573,-0.045359902,0.05067468,0.016670091,-0.07394146,-0.029782848,0.0022060713,-0.06536527,0.035610266,0.057148788,0.0023933202,-0.031784862,0.04322796,-0.03599209,0.0077896826,0.0966159,-0.025406817,0.0203131,0.00475318,0.07276077,0.04515368,-0.013493125,-0.03000283,0.06443467,0.028414529,-0.053163856,-0.07395493,-0.013340703,0.06352197,0.053833008,-0.029538384,-0.030113397,0.06755738,0.08990786,0.031890854,0.020745471,-0.0033159086,0.057765346,0.057988998,0.023337647,0.0082730595,-0.026897691,0.005640148,-0.05965644,0.015597225,-0.034850456,0.034331843,0.06592303,-0.022178492,-0.016649399,0.01411231,-0.1091006,-0.06867232,-0.022269985,0.05239881,-0.042018708,0.008026995,-0.034617633,-0.0040770196,-0.06704725,-0.04428788,0.07944691,0.058436237,0.07277006,-0.039708123,0.008482862,0.0045801727,0.070315614,-0.012673877,-0.033594523,-0.019804267,-0.023041412,-0.002326097,0.06718221,-0.024895335,-0.021783417,0.027156068,0.01279909,0.006648896,0.030986393,0.019174816,0.06183434,0.015574953,-0.011563035,-0.0031575996,0.04054075,-0.03232713,-2.707482e-08,0.03767673,-0.024496226,0.039938644,-0.045126297,-0.013111262,0.05980931,-0.030672781,-0.029726107,0.14071202,-0.022250637,-0.06149202,0.0739364,0.044194814,0.0087940935,0.00720737,0.09274959,-0.06362756,-0.01931629,-0.013083826,-0.031130522,-0.014773575,-0.0098059345,-0.014627909,0.107844785,0.058551166,-0.04064734,0.014126212,0.06745968,-0.06533216,-0.076573476,0.043756556,-0.03382254,-0.07382419,-0.007059539,-0.04194334,-0.008982156,0.029526163,-0.052178863,-0.032501914,0.035588484,0.021204282,-0.019480128,-0.08655307,-0.0024403406,0.08621652,0.053579863,-0.04366063,-0.018490834,-0.024166968,-0.030224374,0.002475205,0.00861529,-0.0074190856,-0.0831408,-0.08481417,-0.008202203,-0.0373663,-0.06553163,-0.029591125,-0.023845565,0.038275782,0.020076936,0.1699901,0.0074452558 +3.6.3.37,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A eukaryotic enzyme that imports guanine and tryptophan (it contains a single ATP-binding site).",384,1.0,-0.04466479,-0.05739833,-0.01464537,-0.029443616,-0.07380145,0.025822345,0.08026076,0.024459157,0.053392895,-0.05135025,0.02618868,-0.07275184,-0.045124486,0.13241856,-0.046228416,-0.07883285,-0.064223826,-0.0107347155,0.083206125,0.00026219754,0.0552557,0.08006057,-0.034193818,0.03339492,-0.06526331,-0.0069319364,0.0023202882,-0.029315297,-0.024247827,-0.024480825,-0.15425168,-0.0135744205,-0.0066484637,0.064175956,0.013545048,0.09894718,-0.07327113,0.000116735006,0.04300996,0.019945135,0.11564948,0.028600935,0.07675399,0.111427575,-0.086495645,0.010590653,0.030460501,0.008836064,-0.043087237,-0.014514559,-0.020317227,-0.025051607,-0.066108935,0.03863156,-0.01594571,0.03083688,-0.028022287,0.012700947,0.025612408,0.00462205,0.0028141448,0.00499564,0.071049914,0.05523421,0.055088215,-0.010530847,-0.035705697,-0.014223589,-0.012093298,-0.05273792,-0.06346413,-0.067255765,-0.06711824,0.07010671,-0.010858697,0.012999919,-0.027727664,0.0058676717,-0.060821038,-0.026761035,0.009969602,-0.022357749,-0.056271326,0.00041161993,0.059522804,-0.00767746,-0.00061922806,0.031721562,0.014369414,0.008426744,0.008937736,-0.027739221,0.008852819,-0.04363372,-0.07296625,-0.0045081005,0.0164383,0.020988382,0.019644253,-0.0185918,0.077168375,0.056808908,0.06260103,0.004934076,0.023537472,0.0043258956,0.032017555,-0.035004433,-0.033246115,0.012661838,-0.054410838,0.019572718,0.03161381,-0.05806623,-0.009057104,0.07621074,-0.059427086,0.014049124,-0.05895353,0.042486258,-0.05533474,-0.09517325,0.012112735,-0.025356317,-0.028657693,0.043138195,-0.07360445,-1.2377498e-33,-0.05531558,-0.06387371,0.027390404,-0.008439258,-0.010333947,0.025060004,-0.030829333,-0.03130947,-0.03241942,-0.06658114,-0.018576324,-0.031360626,-0.004414604,0.085686125,-0.018551327,0.031880684,-0.08945737,0.030697221,0.087146066,-0.03139091,0.04959171,0.058315694,-0.03363225,-0.044682242,0.05217786,0.005043372,-0.04192645,0.009516724,0.078536436,-0.0053112092,9.33336e-06,-0.069504246,-0.14760433,-0.011545993,0.00032620307,-0.07785112,-0.0362752,-0.006963515,0.070060246,-0.09144142,-0.10262413,-0.02390671,-0.044808045,0.05471164,0.043270513,-0.047495745,-0.024815718,0.08138864,-0.03130923,0.010259829,0.04423554,-0.15438755,0.08881694,-0.055318102,-0.020570077,-0.01528695,-0.0041915085,0.04478768,-0.045764674,0.047084652,0.10628525,0.10508005,-0.03561729,-0.018216401,-0.011274953,0.08078717,-0.12459031,-0.123081386,0.058110423,0.07843602,0.012392584,0.013434471,0.06254137,0.03364372,0.06231676,0.004241566,-0.03877779,-0.04505508,-0.023256717,0.07201509,-0.040497415,-0.08293165,0.04408688,0.023442857,-0.06256891,-0.046056155,-0.004121617,-0.021763017,0.019538527,-0.0300044,0.0911518,0.079248056,-0.04922528,0.103700995,0.0672309,-1.803187e-34,0.08071517,-0.02981321,0.08663973,-0.10508204,-0.03141364,-0.0034297623,0.0036329736,-0.053748272,0.0052137454,-0.044832002,0.03178797,-0.000565037,-0.02421484,-0.034293555,0.007570112,-0.07919787,-0.034326423,0.068028055,0.014691789,-0.010511805,-0.006890483,-0.016976435,0.008296659,0.045668088,-0.046671182,0.025647173,-0.041942317,0.08674059,-0.017978624,0.03508208,-0.062199745,0.021481734,-0.022334348,-0.0025997448,-0.07599029,0.00029291702,0.028925018,0.08586274,-0.02446873,-0.01619979,0.042034358,0.074112415,0.056890104,0.05333496,0.018686041,0.11430967,0.023607101,0.022784343,0.016590077,-0.044418547,-0.00062064553,0.028586945,-0.051637914,-0.00020320206,0.06635605,0.114232935,-0.023044012,-0.01848142,-0.0137167955,-0.086279094,-0.05787677,-0.108031824,0.06274892,-0.038267046,0.01409845,-0.008258757,0.008413678,-0.012996733,-0.008550159,0.06988149,0.067681365,0.07674579,-0.02134227,-0.016805321,0.0036827289,0.02757844,0.017037965,-0.040848825,-0.016307767,-0.053174686,0.021077318,0.08519914,-0.048273135,0.014905847,0.056576688,0.02950815,-0.022794655,0.004506852,0.013990515,0.065624356,-0.010833625,0.010490979,0.005243861,0.055916555,-0.008362333,-3.2590098e-08,0.013311217,-0.025376325,0.03381092,-0.0876397,0.01732618,0.045768563,-0.062064957,0.012959628,0.13920657,-0.0055793133,-0.02128436,0.058972318,0.008775776,0.05067796,0.093340866,0.055720136,-0.049555857,0.018925976,0.010287638,-0.019094534,-0.01671373,-0.060105216,-0.06478555,0.10962841,0.0049929046,-0.039555464,0.024833033,0.0634885,-0.032336876,-0.049729742,0.023898734,0.002743924,-0.017658254,-0.015232363,-0.025618227,0.045123097,-0.019899137,-0.0120552555,-0.08575054,0.026531756,-0.004437396,-0.04886964,-0.06915572,0.009763192,0.074095726,0.013829674,0.0016773379,0.009185415,0.0047867,0.005531873,0.053553365,0.023713302,-0.007848013,-0.025907671,-0.06788059,0.00073597976,-0.042336844,-0.04842358,-0.03952432,0.0153185595,0.06801745,0.0028987052,0.17613277,-0.012254128 +3.6.3.38,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme that exports capsular polysaccharide from Gram-negative bacteria.",384,1.0,-0.031158498,-0.07217869,0.007594228,-0.03078302,-0.08519014,0.02544983,0.040854286,0.038526684,0.057700407,-0.01993746,0.024183625,-0.04822672,0.01186705,0.10892294,-0.083959244,-0.10311507,-0.04554078,0.011051724,0.055764705,-0.0059158946,0.09275328,0.07057184,-0.04251916,0.010996111,-0.027917536,-0.002086083,0.017493926,-0.040803947,-0.037707966,-0.02986327,-0.12150959,-0.01403872,0.019060642,0.0050394936,0.025917051,0.11412966,-0.035812985,0.011786221,0.109788865,-0.011637064,0.11631905,0.040016398,0.09175835,0.078931205,-0.092227966,-0.023840422,0.020563006,0.01356661,0.008730722,-0.028066479,-0.019051788,-0.012634499,-0.071434945,0.033157475,-0.022600446,0.05272351,-0.020276526,-0.013090679,0.004829771,0.004838852,-0.023617078,-0.014026068,0.06753247,0.0603652,0.030499632,-0.028736768,-0.007915483,0.010861274,-0.04159032,-0.026231289,-0.12662677,-0.030517511,-0.057913214,0.030888734,0.039145395,-0.011024431,-0.050827187,-0.0046882974,-0.06419194,0.00031116337,0.008269711,-0.050766528,-0.055449966,0.0339414,0.0016567899,-0.04413026,0.017839286,0.0020283458,0.015966177,0.026302546,-0.05486144,-0.018408375,0.03974651,-0.03763264,-0.10996848,-0.034223445,0.010018716,0.061255362,0.04787309,-0.028838163,0.05468163,0.04055959,0.069082595,-0.055603378,0.027531344,0.0048527666,-0.01890419,-0.011978499,0.0073337234,0.0050219772,-0.02167149,0.0700654,-0.016224345,-0.08816248,-0.020968024,0.0812612,-0.030542364,-0.026495576,-0.08455024,-0.0071872817,-0.06930579,-0.15055984,0.03798862,-0.04548693,-0.02959328,0.04622099,-0.047757734,-1.2049214e-33,-0.08445766,-0.075859234,0.065636344,-0.018229201,-0.004177369,-0.010601331,-0.031350467,-0.03415087,-0.04274956,-0.07440628,0.008918704,-0.023015637,0.008089727,0.07402864,0.012126379,0.017080633,-0.051764585,0.0060659642,0.048801694,-0.017283697,0.030460907,0.0643589,0.003619491,-0.046729542,0.09269986,0.01194357,-0.051781226,0.011982495,0.08540552,-0.0027596075,0.011499679,-0.021510907,-0.13856196,-0.012077821,0.022941142,-0.04372948,-0.059824526,-0.02950118,0.06429185,-0.06922691,-0.074665785,0.0059239855,-0.026926853,0.010166879,0.040270485,-0.023396272,-0.012329846,0.057772294,-0.04946464,0.06736821,0.05826618,-0.11392574,0.08745673,-0.051571283,-0.015522565,-0.0008608763,-0.007761504,0.063083075,-0.058255132,0.061941687,0.1128345,0.08895447,-0.0424411,-0.0179589,-0.025933752,0.06995953,-0.085837975,-0.09188108,0.053887293,0.056894287,-0.0031311973,0.013888875,-0.021134464,0.06993322,0.053824715,0.02027082,-0.03569017,-0.009792175,0.019070663,0.0160168,-0.011117435,-0.057618767,0.04414787,0.008950425,-0.07118953,-0.045301557,-0.013473927,-0.01802157,0.020847129,-0.007525944,0.08602536,0.050726227,-0.07599054,0.14864737,0.034125164,-9.277814e-34,0.09846176,-0.07191889,0.051915158,-0.100740984,-0.04892798,-0.0054889554,0.027495187,-0.008370124,-0.007252826,-0.064756446,0.02809228,0.026687423,-0.06429782,0.012446651,-0.01793073,-0.074732386,0.0015537508,0.05561813,-0.027583404,0.009093797,-0.00028403968,0.02936375,0.039360803,0.05397264,-0.034010515,0.0014001972,-0.058725815,0.12965529,-0.031306215,0.010718026,-0.015111926,0.06809133,0.014970347,-0.026642442,-0.10775617,-0.034799974,-0.019793218,0.032986134,0.02561643,5.5529552e-05,0.043071415,0.08586203,0.054904543,0.02442747,0.0059384126,0.07464238,0.013996553,0.029632917,0.044582367,-0.01595635,-0.031584997,0.019647429,0.0075362613,0.009835123,0.05439612,0.09444857,-0.008790521,0.003035224,0.021640344,-0.120805606,-0.07868375,-0.07801496,0.090203896,-0.048309095,0.01903873,-0.005747293,0.02755937,-0.06581092,-0.023533246,0.05432278,0.078119755,0.065897204,-0.06908666,-0.0068977997,-0.011639964,0.0393128,-0.041931495,-0.027582474,-0.056128513,-0.033931613,-0.026332943,0.06169324,-0.036298927,-0.0108017465,0.08178214,0.007729301,-0.004672614,-2.0232932e-05,0.008047517,0.079950355,0.018303521,-0.0047664023,-0.010816956,0.06135852,0.0047524516,-3.0999416e-08,0.028760716,-0.026745282,0.020271068,-0.07175404,-0.02262945,0.0748149,-0.06105467,-0.032139186,0.10792211,-0.0048256866,-0.0124548655,0.084457085,-0.0057363305,0.056316447,0.056125388,0.077770665,-0.047147524,-0.0003356085,-0.004959325,-0.01992976,-0.051882245,-0.059957918,-0.062848754,0.12108985,0.027962063,-0.03890484,0.027957678,0.050514936,-0.015223255,-0.07167212,0.02698573,0.048654623,-0.039181273,-0.04134824,-0.038217507,0.0305765,-0.00736939,-0.01132635,-0.053115644,0.058476616,0.043590263,-0.033089746,-0.06956688,-1.6916973e-05,0.06930383,0.07975834,-0.029991083,0.065873615,-0.009887187,0.022639008,0.048689168,0.0112740975,-0.040019013,-0.038879536,-0.062155124,0.010838083,-0.053934917,-0.027915811,-0.014880974,0.0035966071,0.042263083,-0.007489584,0.15068719,-0.01104891 +3.6.3.39,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Enzymes of Gram-negative bacteria that export lipo-oligosaccharides and lipopolysaccharides.",384,1.0,-0.054481916,-0.06610421,-0.004601517,-0.0073726093,-0.09320057,0.028448682,0.021120245,0.013577364,0.058820523,-0.025832927,0.02553673,-0.05452007,0.015999332,0.091937706,-0.051399637,-0.07461729,-0.01950152,0.013481646,0.02629146,0.012971532,0.09168776,0.0659381,-0.057643317,0.0051906244,-0.033986174,-0.0065388554,0.0150362095,-0.02666576,-0.042020213,-0.019574992,-0.105128594,-0.015618193,0.01975704,-0.024896212,0.047343396,0.07961754,-0.015011583,0.016850889,0.11828916,-0.0030658576,0.104337595,0.022827983,0.08338302,0.06879097,-0.0937628,-0.022470845,0.055224538,0.02585279,0.042772815,-0.037437584,-0.03216901,0.0006257909,-0.09025462,0.05333092,-0.011592585,0.034390524,-0.019506784,-0.016214458,-0.029108936,-0.009563898,-0.03796796,-0.015717072,0.080234185,0.07961273,0.0018022116,-0.029290063,-0.02486534,0.005568943,-0.007770178,-0.02435082,-0.11111813,-0.04648486,-0.016151566,0.04605829,0.037988003,0.02147965,-0.024508879,0.0091286795,-0.049752057,-0.06009953,0.038543653,-0.07606366,-0.063139126,0.052842643,0.015624352,-0.057628695,0.029327987,-0.019903814,0.04342803,0.035992373,-0.043252118,-0.050907698,0.050658368,-0.057375435,-0.104572624,-0.05235836,-0.0025747223,0.05903537,0.053473603,-0.039077334,0.050102044,0.03015302,0.05922926,-0.01584982,0.017252028,0.0062007844,-0.0021538574,0.003386213,-0.0007982522,0.024603443,0.0035333226,0.045367725,0.049071997,-0.097062595,-0.031971775,0.039734207,-0.038844243,-0.024799185,-0.10662376,0.0055148453,-0.086551435,-0.12839863,0.04721384,-0.040438328,-0.026389265,0.08050214,-0.03965347,1.2390157e-35,-0.069059834,-0.07205215,0.07502826,-0.039937906,0.0066056373,-0.0129280295,-0.04731273,-0.03469966,-0.02035203,-0.076383926,0.025588922,-0.04923519,-0.010908635,0.06541966,0.005248739,0.04679898,-0.055107895,0.011538656,0.057668664,0.015557378,0.033139564,0.047309697,0.0054627373,-0.049192566,0.110394135,0.022743147,-0.040795483,-0.005428524,0.040896267,-0.014486487,0.02309134,-0.036997266,-0.122110754,-0.029863259,0.050475497,-0.02950731,-0.046528477,-0.010202712,0.072406106,-0.08206776,-0.10251399,-0.0053971224,-0.056145843,0.02389289,0.023843702,-0.014065786,-0.026588267,0.036808543,-0.002046141,0.02873299,0.04639976,-0.13143177,0.08992764,-0.018333847,-0.0050071315,-0.035245337,-0.006570411,0.048159905,-0.02774949,0.04670282,0.07573425,0.11966098,-0.06436446,-0.035184048,-0.019763472,0.036354937,-0.081393465,-0.09192846,0.034465767,0.067836896,0.0092362175,0.023063997,-0.01315225,0.051099133,0.074479595,0.02392108,-0.040095184,-0.04031882,0.01544775,0.02218747,0.005709772,-0.05556561,0.06405484,0.00026444765,-0.0647692,-0.02146189,-0.030197259,-0.023946464,0.03444062,0.00066526793,0.07283598,0.05520249,-0.07448173,0.14487997,-0.0051387316,-2.1767731e-33,0.085194215,-0.063320704,0.09107215,-0.12157477,-0.05004236,0.031780034,-0.0026669598,0.025769064,0.029503994,-0.02212983,0.020636544,0.0317933,-0.052889444,0.0019525874,-0.004122407,-0.08580707,-0.008127521,0.052754663,-0.009694708,-0.024147155,0.003749415,0.026388222,0.021431526,0.053806707,-0.019151783,-0.003312581,-0.045348756,0.14050405,-0.041649196,0.02274476,0.0043078773,0.057905342,-0.0032516816,-0.029138431,-0.099010035,-0.004738829,-0.023839498,0.06174777,-0.0061020423,0.0066386214,0.048345454,0.08094771,0.06173383,-0.002161307,-0.024859738,0.063540794,-0.018877506,0.0402697,0.03241752,-0.011783135,-0.012087931,0.009792021,-0.0064300373,0.014053775,0.07204279,0.09085019,-0.014822853,0.00544394,0.027412994,-0.107948035,-0.09287265,-0.08209919,0.082456954,-0.05583663,0.021549571,0.036715273,0.047896426,-0.030679123,-0.023665885,0.042535562,0.046878807,0.09735057,-0.06732799,-0.021726198,0.0247568,0.06951279,-0.051069528,-0.047933854,-0.0432046,-0.020459814,-0.007392991,0.050458558,-0.016759679,-0.011887944,0.05862632,0.026178006,-0.019264258,0.003944877,0.015845496,0.09594024,0.008343864,-0.011911216,0.002339613,0.009359212,-0.0033264176,-3.1952943e-08,-0.0033786586,-0.03511393,0.055872492,-0.07279243,-0.030422999,0.04022016,-0.06254281,-0.004016461,0.13953586,0.010518539,0.014061461,0.08280273,0.0070332424,0.0388844,0.042488135,0.054798797,-0.047626648,-0.015735982,-0.0020877563,-0.03146855,-0.037765745,-0.071553536,-0.06988888,0.13612373,0.056495886,-0.078109704,0.042716224,0.010116033,-0.050633058,-0.067184515,0.017695306,0.027994258,-0.0364112,-0.020531675,-0.0324062,-0.023583166,-0.042051405,-0.025012512,-0.060917042,0.0642867,0.028073592,-0.023237187,-0.07014817,-0.0050060153,0.0509933,0.06841681,-0.015253417,0.047215443,-0.0387581,-0.0106858555,0.043660883,0.021913406,-0.030675301,-0.043577794,-0.079227425,-0.03792115,-0.05251249,-0.0048972825,-0.020438652,0.018930605,0.04204962,-0.018330742,0.17532569,-0.0115039125 +3.6.3.40,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme found in Gram-positive bacteria that exports teichoic acid.",384,1.0,-0.037217997,-0.061021607,-0.028868666,-0.043369565,-0.06806256,0.06913393,0.0073120403,0.057635173,0.07182304,-0.028172422,0.040373832,-0.08478568,0.007513319,0.09697641,-0.042139813,-0.102021575,-0.023601461,-0.013208931,0.067152,-0.02858761,0.04505198,0.094664164,-0.036390055,0.017536296,-0.060175855,0.008615553,0.022148792,-0.016300838,-0.01815329,-0.0074256086,-0.113667786,-0.0050191833,0.014872009,-0.0097259125,0.032344617,0.1043743,-0.06921989,0.0017093382,0.09285538,0.017188378,0.104549706,0.01960754,0.08746273,0.06151995,-0.09013758,-0.02749667,0.06335438,0.055235375,-0.00091922807,-0.008597155,-0.042273786,0.0038930783,-0.06198167,0.057129912,-0.04426592,0.04571142,0.017049342,0.0089730965,-0.018959096,0.010333941,-0.02270571,-0.01108448,0.07892373,0.06267394,0.032219235,0.0031315484,-0.042542025,-0.01944231,-0.0024295067,-0.067590065,-0.088079706,-0.041850563,-0.0069702035,0.05021945,0.015211657,-0.0049562952,0.0041717766,-0.014959904,-0.05335881,-0.026212692,0.0008537554,-0.07239719,-0.08389552,0.00593573,0.020185312,-0.053754844,0.009570027,-0.00759091,0.07477722,0.04463782,-0.016247107,-0.02092395,0.032100834,-0.07325673,-0.091306105,-0.027727146,-0.005244071,0.04703646,0.03786239,-0.0672098,0.05634493,0.074729376,0.031013122,-0.016161464,-0.0061714463,0.004880204,0.004661208,0.043464288,-0.0099374335,-0.0009552751,0.003735597,0.01987755,0.041194286,-0.08040496,-0.015070221,0.05723105,-0.057987705,-0.03291356,-0.09601927,0.0290541,-0.056750484,-0.13152543,0.017120346,-0.037418965,-0.0045491736,0.0459752,-0.043750748,-1.5394472e-33,-0.025548397,-0.034674976,0.02736814,-0.030134715,-0.020545997,0.013141692,-0.043377228,-0.022535985,-0.03567161,-0.08358884,-0.0005142561,-0.020510824,-0.017151099,0.042900365,0.0027113117,0.029608812,-0.0823314,0.026665216,0.06437987,0.008941662,0.026674846,0.073124014,0.0036308758,-0.050622992,0.0730678,0.042948324,-0.019407105,0.014697589,0.040013824,-0.0001469646,0.014031242,-0.044086173,-0.1606498,-0.03171415,0.07060974,-0.051629648,-0.07371741,0.024833001,0.08569446,-0.07430578,-0.0662056,0.0045982786,-0.021958862,0.046348374,0.059743237,-0.046124097,-0.00066986814,0.0642023,-0.017688384,0.017509816,0.071943186,-0.113896124,0.12547602,-0.04962635,-0.03533019,-0.029483587,-0.015869824,0.075393535,-0.056392908,0.06267278,0.091509536,0.12863813,-0.045433123,0.009895481,-0.0557063,0.011310172,-0.069512956,-0.103944436,0.067018054,0.06706304,0.02073736,0.03463364,0.044972472,0.04024618,0.0680995,0.01079897,-0.04419206,-0.042794615,0.010434503,0.005677903,-0.02704324,-0.09143281,0.045277044,0.017762933,-0.06405328,-0.032793198,-0.013295236,-0.0015877006,0.025247388,-0.028400557,0.105320506,0.060370795,-0.062630855,0.12735723,0.03427216,-1.1575072e-34,0.08789749,-0.056836855,0.074970275,-0.11795548,-0.053008918,-0.012602434,-0.026755486,0.0015571411,0.00027360508,-0.05069516,0.044220086,0.018128177,-0.05811737,-0.025137544,-0.007565596,-0.086774245,0.018420884,0.052653838,-0.009315092,-0.048359383,0.023808762,-0.02341245,0.010462722,0.061232883,-0.046094652,0.046368405,-0.040272772,0.113645166,0.0021600078,0.030362902,-0.022262402,0.054401223,-0.0021905242,-0.01201368,-0.083228335,0.022659173,0.0032629583,0.03758579,0.050559938,0.035647452,0.081462726,0.065642804,0.042379778,0.017972799,-0.014431734,0.08677458,0.025289938,0.008997578,0.012292458,-0.002084862,0.012919212,-0.01185558,-0.028128678,-0.026912842,0.057959963,0.08959043,-0.063759364,0.0048328647,-0.021308554,-0.10179467,-0.049509257,-0.074621595,0.06602195,-0.02739817,-0.007199339,-0.02908177,0.04048413,-0.018345132,0.0135257915,0.07533978,0.05040688,0.09645131,-0.043340556,-0.0269587,0.037310358,0.030717734,-0.039976906,-0.042994186,-0.029382003,-0.038299378,-0.034513924,0.07525132,-0.027371723,-0.014834708,0.07071436,0.026287831,-0.02926248,-0.006785717,0.0093128085,0.084706284,-0.012906527,0.013159541,-0.0026093796,0.033002704,0.012807814,-3.0432584e-08,0.035796814,-0.042062007,0.04960942,-0.066116214,-0.007202626,0.05290577,-0.05513011,-0.010350032,0.14109622,0.012998796,-0.023472236,0.04521534,-0.0019225767,0.046362586,0.06735513,0.061079375,-0.08484581,-0.046327006,-0.021977743,-0.043595836,-0.028434826,-0.06978955,-0.049866233,0.10728076,0.02227956,-0.030333709,-0.010747295,-0.0047185067,-0.05072631,-0.05156376,0.025567602,-0.0031358055,-0.05334812,-0.018941602,-0.026370507,0.0056218565,-0.007839936,-0.023976402,-0.074465804,0.054300204,0.012605938,-0.008267642,-0.107472174,0.028292626,0.072709925,0.0494988,-0.014658238,0.073185265,-0.024905203,-0.024863446,0.0023993147,0.009093702,-0.025696287,-0.044665188,-0.07799509,-0.035621036,-0.04087476,-0.029014057,-0.022882905,0.004344204,0.060380276,0.015021456,0.15397662,-0.039672878 +3.6.3.41,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme found in Gram-negative bacteria that exports heme.",384,1.0,-0.061742604,-0.03230824,0.008075375,-0.028888619,-0.08771492,0.021825397,0.043090653,0.08308792,0.056902517,-0.029458586,0.0066405553,-0.056318775,-0.0005748166,0.11244297,-0.045077313,-0.067612454,-0.050994232,0.007239974,0.023358423,-0.028599909,0.058054607,0.11783329,-0.06421969,0.027544737,-0.047602534,-0.016762706,0.040150877,-0.017595991,-0.036924027,-0.031405132,-0.10672529,3.0511937e-05,0.030746384,0.010318595,0.0579938,0.08361229,-0.02654885,-0.034804933,0.092056245,0.012993536,0.13914528,0.021712402,0.04001516,0.07209198,-0.11559206,0.0018020313,0.0720863,0.0116610825,-0.0027049594,-0.0035332113,-0.015241641,0.014595269,-0.08504786,0.05884586,-0.03836394,0.020272987,-0.0017061749,0.020254808,0.002361167,-0.03233291,-0.031855427,-0.00094560167,0.05711711,0.053997844,0.0155872535,-0.04225246,-0.018135568,0.0070456336,-0.035509154,-0.06263014,-0.083427206,-0.06633112,-0.052463055,0.059219927,0.011037165,0.01519272,-0.008475245,0.0018138957,-0.052485242,-0.036475863,0.017507762,-0.046198316,-0.026422672,0.053462215,0.015916917,-0.019984836,0.011648955,0.0018814619,0.02147046,0.0206978,-0.053151388,-0.02632692,0.019141244,-0.08529885,-0.06597527,-0.017739868,0.011856807,0.07569744,0.033989076,-0.01757629,0.057846893,0.063532606,0.04182794,0.00012905849,0.01735462,-0.023077024,0.00542606,0.013941001,0.043279525,-0.017483283,-0.0112973135,0.033961553,0.05343814,-0.088523604,-0.033104368,0.062122617,-0.043722443,0.008109817,-0.088343956,0.0044668927,-0.06758392,-0.12139157,0.041930884,-0.056009293,-0.013697959,0.030274516,-0.061254416,-1.7541393e-33,-0.067420706,-0.061681937,0.06543404,-0.038509447,-0.027626533,-0.017967502,-0.07385807,-0.012750098,-0.024962412,-0.081148766,0.016779155,-0.037792098,0.0010314753,0.036040116,-0.007646207,0.023335623,-0.05682311,0.0064773406,0.03912273,0.0045036753,0.051250752,0.036138676,-0.0048393128,-0.059379417,0.07501159,0.009788886,-0.014069195,-0.0050693564,0.06368533,-0.0087602185,-0.011673568,-0.051079195,-0.100297436,-0.053481236,0.009296962,-0.060858212,-0.05265633,0.0153810475,0.04404249,-0.065692976,-0.08694148,0.016259005,-0.03536821,0.01509257,0.066229194,-0.05612268,-0.015001599,0.035713956,-0.031259593,0.06527068,0.038945306,-0.13613738,0.13708957,-0.054595742,0.010447697,-0.034369636,-0.00735328,0.07010896,-0.008601155,0.0401797,0.14082892,0.1270845,-0.060399164,-0.005583737,-0.0069470536,0.06053348,-0.09096468,-0.096557036,0.0651397,0.074214965,0.0020892485,0.034078833,0.014407019,0.014201278,0.04692235,-0.000482139,-0.043959264,-0.01865553,0.022318149,0.0030661295,-0.0039945077,-0.08364333,0.054757908,0.013830394,-0.06936548,-0.055664215,-0.0015648466,-0.014942749,-0.013950691,-0.013960343,0.1151332,0.021867702,-0.087178014,0.10339718,0.051056713,3.3839036e-34,0.09661096,-0.025601873,0.0462535,-0.12876186,-0.035956323,0.011488035,0.02026726,0.011636955,-0.014752605,-0.03035422,0.055647116,0.050423197,-0.08600819,-0.0008139085,-0.0041054757,-0.07309187,0.01261229,0.027039245,-0.0077708904,0.0030812307,0.009866778,0.016799474,0.019898983,0.058036443,-0.031661026,-0.006320603,-0.051562015,0.12588657,-0.020180143,0.018036764,-0.013493036,0.07504177,0.017521696,-0.019879213,-0.093801014,-0.010554087,0.027016807,0.069317184,-0.0018795336,-0.029857341,0.029366558,0.06105284,0.07395602,0.05272131,-0.00548683,0.1119819,-0.01332292,0.036951963,0.025468852,0.0032125886,-0.025894878,0.025623148,-0.03890523,-0.00987363,0.049542867,0.056822963,-0.03386541,0.021055467,-0.028956842,-0.09051432,-0.07451235,-0.05344506,0.093539014,-0.03069234,0.00047902018,0.0062189065,-0.001678991,-0.013085076,3.0213321e-05,0.055136275,0.060422007,0.1019334,-0.052291796,-0.041531377,0.027189674,0.033031013,0.002363068,-0.031988148,-0.008064126,-0.026068417,-0.04843174,0.07074153,-0.05946983,-0.02430433,0.06506663,0.0142682055,-0.047557853,0.0046177353,-0.0026331327,0.061323978,-0.013956315,-0.009972037,0.0006938016,0.036343455,-0.027040683,-3.0203747e-08,-0.007114356,-0.07104949,0.03668825,-0.05409593,5.95633e-05,0.05683858,-0.062196255,0.015425382,0.15748462,0.026394986,-0.014919167,0.044636466,-0.008396918,0.016151415,0.087061875,0.07193114,-0.055653196,-0.011131191,-0.0088313455,-0.038115457,-0.0050858166,-0.04692135,-0.051944412,0.14060342,0.05880996,-0.07736767,-0.00063401804,-0.0051894123,-0.026605139,-0.050389197,0.05194875,0.04249423,-0.03164475,-0.007080003,-0.023751585,-0.029321685,-0.012685898,0.02793899,-0.06442866,0.042003922,0.039366286,-0.03186364,-0.09849218,-0.009922096,0.07525717,0.087426044,0.008271588,0.05181322,-0.021602875,-0.05124346,0.044511672,0.010928113,-0.013724022,-0.02322035,-0.083809696,-0.019963244,-0.023408618,-0.04556636,0.0027365894,0.0001869365,0.06301367,-0.012030677,0.16677438,0.0039502876 +3.6.3.42,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme found in Gram-negative bacteria that exports beta-glucan.",384,0.99999994,-0.059717115,-0.05456415,-0.00062391046,-0.0102564525,-0.09379353,0.021656718,0.03882057,0.034745786,0.070030704,-0.054532368,0.02372308,-0.0055927895,0.045734186,0.11599828,-0.07426253,-0.08311186,-0.044578806,-0.0029663714,0.05114915,-0.008765727,0.050674457,0.084077716,-0.047011226,0.0047121076,-0.024746092,-0.0038445776,0.018877229,-0.026255691,-0.030301496,-0.017949529,-0.12513876,-0.017503222,0.01001914,0.036952578,0.028356109,0.09649554,-0.07081963,0.0072411303,0.07926404,0.01934268,0.101598054,0.019410819,0.06966024,0.09325479,-0.077998616,-0.0046615647,0.022622073,0.01968681,0.03800638,-0.025114195,-0.0037790714,-0.011088809,-0.07940794,0.06344304,-0.0008222815,-0.0010774075,-0.029515676,-0.009401502,0.008025016,0.021680571,-0.017080741,0.0075435913,0.034329716,0.040725276,0.01753651,-0.027854359,-0.042213604,-0.015852269,-0.02728756,-0.027582442,-0.08776082,-0.045777224,-0.048327643,0.040860955,0.029418707,-0.012434222,-0.030339474,0.02399336,-0.05665431,-0.023211863,0.059218958,-0.054338817,-0.027950056,0.018451849,0.014556567,-0.027755184,0.015611306,0.022720668,0.030298466,0.022393856,-0.0331127,-0.04678047,0.0020670043,-0.05140951,-0.07276837,-0.03564772,0.025010122,0.043336444,0.044936996,-0.03860947,0.041323613,0.023401516,0.082558945,0.00289263,0.006572683,-0.0027766435,0.00069604494,0.046828832,0.0059536914,-0.0081829615,-0.017387787,0.051876705,0.032318536,-0.06822921,-0.040950373,0.07155294,-0.025205458,-0.0095043825,-0.10760193,0.017830478,-0.06482134,-0.118473664,0.0062774876,-0.042878736,-0.04141744,0.06946741,-0.076742895,-1.9845934e-33,-0.05946571,-0.046226684,0.060282294,-0.046495833,-0.018908283,-0.015843308,-0.067244165,-0.052228104,-0.0092713,-0.07487477,0.022183102,-0.0075551295,-0.03249721,0.09149863,0.010045685,0.0768308,-0.053050898,0.0019020665,0.06695781,-0.011941907,0.037443653,0.04480152,-0.005269019,-0.07732986,0.11208287,0.017031215,-0.050077144,0.021794608,0.06771701,-0.014985025,0.0035922078,-0.05909124,-0.097587146,-0.005131123,0.026139533,-0.037516426,-0.04968876,-0.020918587,0.07501634,-0.102789946,-0.062616415,-0.010825061,-0.0397866,0.035157643,0.053370357,-0.029327825,0.0012755073,0.0402588,-0.05532875,0.06287539,0.07097101,-0.10810973,0.076232046,-0.04978415,-0.02034675,0.0020338919,0.00090133795,0.059019722,-0.047588572,0.044322282,0.09658659,0.11416982,-0.034713414,-0.024800535,-0.021361731,0.030063018,-0.09653433,-0.08860853,0.018766738,0.07421122,-0.017080741,0.032520566,0.024687903,0.027354559,0.0514129,0.017206322,-0.028338086,-0.039939933,0.012464566,0.013305328,-0.022297135,-0.062139355,0.03140064,0.02101407,-0.08336861,-0.012073461,0.028582191,-0.03467246,0.029062403,-0.007222915,0.06937559,0.0717933,-0.09296586,0.13623962,0.034174915,5.706996e-35,0.10640322,-0.09152269,0.07954867,-0.10809739,-0.042312697,0.002878432,0.009268275,-0.052722104,0.019704023,-0.019270625,-0.00048732242,0.054496605,-0.0739455,-0.019064907,0.0010186823,-0.10351321,-0.013548511,0.05797253,-0.020221924,-0.0028852336,0.018936565,0.047719542,0.042682055,0.05186181,-0.06475585,-0.017453771,-0.018278982,0.14626098,0.004142532,0.020591907,-0.012451917,0.076833956,0.033576995,-0.032791447,-0.08432353,-0.01369193,0.017758485,0.052945167,0.021167096,-0.01584671,0.07090868,0.08461141,0.020794248,0.023554314,0.02088278,0.12517415,0.046303734,0.036931727,0.034914076,-0.041716043,-0.00648749,-0.004695573,-0.03332403,0.0022592957,0.072643705,0.08326788,-0.038800154,0.021156043,0.016213454,-0.101402536,-0.07689122,-0.082571834,0.056785244,-0.061121967,0.01793577,0.005904136,0.047750913,-0.014290505,0.0014529605,0.09233901,0.041625407,0.069775775,-0.064743,-0.010840165,0.014365586,0.05321193,-0.04867837,-0.054691404,-0.03983067,-0.03223694,-0.044923507,0.10141985,-0.05042046,-0.0027809269,0.06488581,0.025136381,-0.036361787,0.035616465,-0.00080310454,0.06593368,0.0015078557,0.007419123,0.00028990587,0.03215696,-0.030960133,-2.9593217e-08,0.0182931,0.00269891,0.041840322,-0.08024608,-0.013180138,0.041191597,-0.046372492,0.012434805,0.13659674,0.026246175,-0.032096617,0.053609557,-0.004777423,0.010979003,0.049206223,0.06866139,-0.070200905,-0.028641373,0.0004576498,-0.034347996,-0.029509041,-0.04366427,-0.03759501,0.14624532,0.007761541,-0.07508295,0.043941684,0.033095285,-0.057374947,-0.05753167,0.02734133,0.05447736,-0.050515566,-0.047532834,-0.062717415,-0.026588462,-0.01701041,0.016130436,-0.008673919,0.064084455,0.053602982,-0.017157065,-0.079546586,0.005903896,0.015154648,0.06771668,-0.0081173545,0.013162861,-0.0040879725,-0.022551786,0.067212075,0.0071868743,-0.056426346,-0.050438892,-0.08870485,-0.0022345858,-0.056527127,-0.04155016,-0.0005201739,-0.02035322,0.033346348,-0.024924584,0.15153573,-0.009499362 +3.6.3.43,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A family of enzymes that exports alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.",384,1.0,-0.059977353,-0.05825285,-0.030397987,-0.048301067,-0.050284527,0.026955863,0.028867988,0.082926214,0.05846025,-0.059239637,0.01455114,-0.042734284,0.03367063,0.13426793,-0.05825484,-0.0780483,-0.07528926,0.052187387,0.011550131,-0.038648434,0.03407547,0.07713018,-0.049833503,0.039745286,-0.07288885,-0.013401233,-0.0055344007,0.03744569,-0.03376077,-0.008673342,-0.109033965,-0.014461363,0.02261168,-0.008241367,0.07032659,0.104976945,-0.059883192,-0.011478467,0.108190686,0.006261143,0.09676293,0.016056452,0.056174,0.08356415,-0.10369399,-0.021761496,0.056232255,0.029660799,0.030843008,-0.0044674044,-0.012579269,0.027785907,-0.058149286,0.057687193,0.012788393,0.009171711,-0.026466805,-0.024158096,-0.0052981596,-0.00074008666,-0.032070268,-0.008916091,0.046664927,0.059580676,-0.043028012,-0.018079815,-0.029185569,-0.0014741695,-0.023845037,-0.03861286,-0.11516953,-0.07382459,-0.027330954,0.075684905,0.028015854,0.028312631,-0.0031804827,0.0061401576,-0.087030895,-0.06961754,0.047937345,-0.0758865,-0.063853465,0.06926635,0.022197189,-0.04706064,0.028573759,-0.0002691089,0.011294836,0.057388164,0.003922927,-0.04052968,0.059631657,-0.089516945,-0.06035017,-0.01569359,-0.0344881,0.022961898,0.032492876,-0.026009768,0.025733,0.048965495,0.07152959,-0.01697986,-0.00035441158,-0.014016145,0.014130648,0.03652405,0.020821104,-0.017876344,-0.015161311,0.03487701,0.041420817,-0.07736128,-0.019633658,0.06912108,-0.025744146,0.011215689,-0.08345038,-0.0066475086,-0.061818846,-0.09969012,0.04011222,-0.01884874,-0.028727084,0.029554239,-0.047164638,1.0084911e-33,-0.06515283,-0.014193358,0.05958161,-0.030252576,-0.021662598,-0.008493514,-0.080372915,-0.017213492,-0.012380637,-0.08197462,-0.007910853,-0.019005818,-0.015437155,0.042066358,-0.012865712,-0.012616297,-0.052703317,-0.007635104,0.041945215,0.024094133,0.06199468,0.03982242,-0.013360217,-0.04061621,0.10467534,0.02714526,-0.023084909,0.02614428,0.046498552,-0.019045064,-0.020902408,-0.03468287,-0.101215035,-0.048420012,0.021072315,-0.062451467,-0.050321426,0.0018045761,0.100001715,-0.050046593,-0.10815788,-0.008339113,-0.023851093,0.03352985,0.07512679,-0.025104217,-0.025477942,0.0648833,-0.03926804,0.05123798,0.03964978,-0.1399626,0.09859045,-0.0896292,-0.02436608,-0.021000445,0.005598208,0.0633392,-0.045606647,0.041970577,0.12629992,0.12748599,-0.050393783,-0.036724,-0.031439006,0.049605872,-0.069684006,-0.128078,0.023319686,0.058181696,-0.0026690746,0.067436926,0.017184313,0.0065881987,0.08779057,0.035959885,-0.05439075,-0.0067598065,0.031193277,0.026175264,-0.054239135,-0.040777616,0.044797983,0.026808415,-0.04070938,-0.04902416,-0.03639571,0.0015813037,0.031484123,-0.0020941484,0.079319976,0.005440477,-0.047236443,0.11048001,0.019386152,-2.2281464e-33,0.084485464,-0.07358524,0.10364424,-0.11023144,-0.062421095,0.024291497,-0.012850052,0.020174688,0.02227759,-0.0064535486,0.0072689652,0.01794655,-0.08921508,-0.047536384,-0.0112467185,-0.075480506,-0.008545974,0.045141485,-0.0050860206,0.0033448185,0.009102949,0.04652413,0.069462486,0.06570453,0.0046993205,0.007996436,-0.024395749,0.12996377,-0.0056425156,0.032009933,-0.020909626,0.046011504,0.02010821,-0.02699401,-0.09239099,0.0069209165,-0.0011209866,0.057172213,0.0032136673,-0.026769819,0.05065653,0.07061529,0.026363432,0.037028063,-0.022520496,0.10806722,0.021541175,0.043862503,0.029618151,-0.018991575,-0.044829164,0.019601481,0.0173714,-0.007577164,0.035086114,0.091227785,-0.010144565,0.03542614,0.008002296,-0.06940106,-0.054547336,-0.06776694,0.05367749,-0.025410362,0.0016585451,0.0029549024,0.014016252,-0.017671678,0.013033553,0.027864926,0.055942006,0.038465306,-0.03149135,-0.019391203,0.008282932,0.075444475,-0.013937572,-0.08912091,-0.03148726,-0.020989109,-0.045206547,0.07275847,-0.082800455,-0.00600665,0.036485888,0.021025777,-0.010358478,-0.0062543154,0.010181059,0.03211233,0.012939536,0.015900418,0.020398652,0.031677727,-0.033109713,-3.8262588e-08,0.032382768,-0.046083663,0.041693926,-0.061009765,0.002929048,0.038207952,-0.06113615,-0.007862382,0.12316482,0.00037593098,-0.025721595,0.070309475,-0.0108523145,0.014783848,0.050896518,0.08987153,-0.061209578,-0.020377383,0.0074716536,-0.0059761372,-0.004382071,-0.055646632,-0.08752492,0.13558282,0.038376797,-0.07700188,0.006884176,-0.0072035254,-0.048677854,-0.05717463,0.06370228,-0.0019504402,-0.061716385,-0.010412085,-0.0074462085,-0.0060888184,-0.06145216,-0.030149529,-0.04523591,0.040498845,0.04482647,-0.048289713,-0.09181386,0.010561173,0.044379223,0.06515835,-0.010399702,0.027057055,0.006327492,-0.035318647,0.07313124,-0.0050131353,-0.016647853,-0.0662729,-0.06671735,0.012248202,-0.013425787,-0.051701117,0.018175727,-0.0095989555,0.024093315,-0.019164342,0.19861796,0.00093933335 +3.6.3.44,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. The enzyme from Gram-positive bacteria and eukaryotic cells export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione---drug conjugates. Some also show some 'flippase' (phospholipid-translocating ATPase; EC 3.6.3.1) activity.",384,1.0,-0.020087127,-0.045423746,-0.03814082,-0.04647782,-0.066196546,0.006749248,0.0127122225,0.088980734,0.05268664,-0.030285552,0.015350682,-0.008500929,-0.0095321825,0.08248362,-0.03146324,-0.03534436,-0.07270962,0.011035522,-0.012514096,-0.009568871,0.05904755,0.03603682,-0.06957001,0.020772919,-0.033787794,0.06613283,0.018614493,-0.053902466,-0.050682053,-0.017876705,-0.1074479,-0.033907477,-0.022353811,0.015225945,0.029836548,0.09376886,-0.10838265,0.0020416048,0.1179397,0.013910469,0.1372176,0.012373571,0.06441516,0.03494384,-0.043071724,-0.023516824,0.011695278,0.038024127,0.059106592,0.0159358,-0.019047366,-0.0161421,-0.05075379,0.08636918,-0.033682942,0.005048478,-0.02184663,0.011961584,0.0021291603,0.08154211,-0.03147206,-0.011123342,0.06928726,0.04989886,0.017815134,-0.06282827,-0.0528117,-0.0139785,-0.016311226,-0.03430193,-0.067085415,-0.068761505,0.0012230071,0.05030178,0.0018566692,0.019290123,-0.04733481,0.037711345,-0.07493747,-0.064273395,0.082436636,-0.088540144,-0.030806264,0.0460768,0.069890454,-0.056248862,-0.0026843916,0.027119793,0.037853036,0.024982095,0.011968029,-0.0080734,0.03570158,-0.052990872,-0.08409836,-0.019893682,-0.01646446,0.067088924,0.01118814,-0.02443134,0.07897192,0.055680178,0.06200918,0.011961782,-0.011049022,-0.008012114,0.049496133,0.025104733,-0.05803988,-0.0119462395,0.00074096414,0.025141878,0.062259194,-0.05707009,-0.042676665,0.06375377,-0.010863607,8.8258785e-05,-0.09172096,0.020415414,-0.055099085,-0.10249683,0.096773036,-0.029848611,-0.0144184325,0.045466695,-0.04246788,1.223296e-33,-0.05745806,-0.010175045,0.026058577,-0.0096926,0.0013354141,0.01769464,-0.035800662,-0.044995937,-0.041280687,-0.06715772,-0.03113373,0.011035167,-0.022685196,0.056093477,-0.046283636,0.05673911,-0.03908528,0.008134724,0.07314536,-0.04383071,0.056763444,-0.0014270224,-0.05285227,-0.051041555,0.019557461,0.020580487,-0.08849,0.008471613,0.034009602,-0.018424882,0.022709563,-0.038697977,-0.10283473,-0.018776825,0.019889059,-0.013443676,-0.053818475,-0.037959706,0.033543676,-0.06472099,-0.09222742,-0.0035278113,-0.02852635,-0.004978785,0.06107304,-0.006958597,-0.07400828,0.039051045,-0.04221392,0.041892808,0.01757397,-0.14575928,0.093030445,-0.058707733,-0.031994272,-0.02884256,-0.0195317,0.020990225,0.0049466835,0.096380435,0.07527798,0.15345845,-0.109333865,-0.035586532,-0.030307034,0.06425143,-0.077679195,-0.08903643,-0.011525764,0.09358047,-0.020431416,0.009343368,-0.00019363746,0.04733414,0.06654448,0.012964244,0.0040849536,-0.022231646,-0.031863466,0.047480717,0.00355137,-0.08013389,0.047523588,0.015207781,-0.08437788,-0.022153825,0.000525846,-0.06552472,-0.010945447,0.0017643521,0.0911345,0.026114719,-0.07278278,0.09693382,0.024422826,-2.8588034e-33,0.077805035,-0.05508786,0.086921275,-0.12603574,-0.04770543,0.056512095,0.0011080916,-0.012953934,0.06454442,-0.002718125,0.030707533,0.0023133573,-0.043507613,-0.05975458,-0.014474015,-0.05822034,-0.004632155,0.08315899,0.010974059,-0.0067144386,-0.016385924,0.0987961,0.03761294,0.11450963,-0.02538317,-0.008613236,-0.011160457,0.075075895,0.009014197,0.0539991,-0.026450055,0.054054722,-0.014162152,-0.008198813,-0.095482066,-0.01765438,-0.018973807,0.025124816,0.03901706,-0.015718574,0.06634504,0.065484725,0.04411651,0.014040693,-0.01951592,0.07135554,-0.052670456,0.09464904,-0.014109154,-0.066554464,-0.001269554,0.007911953,-0.005198721,-0.0076105595,0.10170152,0.07200706,-0.013810617,-0.014611964,-0.025117999,-0.10225172,-0.063793875,-0.08599302,0.025778824,-0.09164416,0.01635137,0.0069652535,0.025355585,0.020734912,-0.034315504,0.08212192,0.015068354,0.0379388,-0.012014021,-0.024006765,-0.018865518,0.04311472,-0.019260122,-0.055164654,-0.003114728,-0.004888558,0.02524492,0.033359505,-0.025393115,-0.038480543,0.043213982,0.015765116,-0.024033014,0.059914105,0.038359288,0.08207258,-0.004800125,-0.0077200294,0.0030111829,0.03082042,-0.013281622,-4.1906283e-08,0.057043303,-0.012625947,0.08600499,-0.056238346,-0.023516389,0.0733627,-0.03507387,0.008989405,0.09592575,0.0044718664,-0.031087635,0.08036506,-0.017398436,0.0003014988,0.008858155,0.10324402,-0.090841845,0.015389615,0.02442005,-0.010086502,-0.027192226,-0.0786359,-0.015654914,0.08851384,0.063910246,-0.059180997,0.028815223,0.0035418307,-0.021260766,-0.043463092,0.007820598,-0.03416956,-0.0058842036,0.0047352198,-0.073034346,-0.01779602,-0.031989336,-0.025419094,-0.08653494,0.060737953,0.051163953,-0.030232972,-0.076574944,0.027803952,0.025294892,0.068965316,0.04179042,0.037696514,-0.018311463,-0.0560569,0.03383334,-0.024124516,0.0053797495,-0.06582134,-0.07630947,0.0026614475,-0.06174602,-0.033820864,-0.01120852,-0.04078137,0.036575057,0.0016192241,0.18812275,0.05109772 +3.6.3.45,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A yeast protein that exports a variety of xenobiotics, especially steroids.",384,1.0,-0.010712529,-0.058847327,-0.004133105,-0.06559946,-0.060439903,0.034190264,0.045193683,0.042683907,0.038258594,-0.053560883,0.04149999,-0.047464717,-0.04581258,0.08765257,-0.027197132,-0.071499445,-0.044398665,0.029621782,0.06698766,0.017804196,0.07398231,0.101316296,0.008792037,0.03705838,-0.045676168,-0.008527463,0.017742325,-0.030018302,-0.044229787,-0.041319463,-0.114048205,0.0069628768,0.0075439895,0.02879626,0.016438305,0.100225225,-0.0105184475,-0.03147969,0.07531029,0.022679318,0.11492945,-0.024042044,0.055565327,0.08728801,-0.11316253,0.007658357,0.03738133,0.031685565,0.019609058,-0.011695416,0.0012929721,-0.04421535,-0.039863985,0.04734675,-0.0040259287,0.04062469,-0.03647141,0.009655104,-0.029375773,0.003231606,-0.023419684,0.006482348,0.06432901,0.09764284,0.017447663,-0.023020165,-0.036514748,0.016260786,-0.0214243,-0.040750183,-0.08788119,-0.034524918,-0.080961294,0.03658542,0.03513005,0.026208688,0.018862529,-0.03719421,-0.058535438,-0.041674394,0.022710728,-0.0015654728,-0.04216272,0.0064133503,0.0547796,-0.06413594,0.03300463,0.027243327,0.009671017,0.079831645,-0.034560718,0.0076995343,0.052782625,-0.014419333,-0.08990976,0.00083973794,0.062534794,0.07736734,0.023169536,-0.039555702,0.051307857,0.063207775,0.07095053,0.02347172,0.03507855,0.006657505,-0.010140394,-0.0015680193,-0.05505241,0.007024628,-0.017580537,-0.009272522,0.010626347,-0.082454495,0.016444167,0.048206024,-0.031440694,0.0057784175,-0.10137109,-0.021760132,-0.067686014,-0.100911275,-0.008033344,-0.027790776,-0.042413738,0.030298326,-0.046898488,-2.052757e-33,-0.06386942,-0.020793488,-0.008776374,-0.014217805,-0.02206163,0.009411955,-0.022347758,0.024697077,-0.04088018,-0.069912,0.0076127658,0.024319794,-0.032098785,0.08528199,-0.017703379,-0.013336729,-0.029808687,0.084427044,0.07766891,-0.00046692192,0.047996994,0.041484676,-0.021765934,-0.04616986,0.05140229,0.022887472,-0.050574746,-0.014104217,0.033756413,-0.019739281,-0.037818175,-0.09366146,-0.07809833,-0.013498024,-0.019207006,-0.060666014,-0.009006102,-0.027837547,0.055240117,-0.0671636,-0.085963495,-0.02787888,-0.048107557,0.018150639,0.035697855,-0.021634901,-0.049215764,0.0021238332,-0.012155012,0.034170993,0.03401104,-0.12749916,0.111406736,-0.014567194,0.0038265984,-0.0046393187,-0.031957556,0.08035091,-0.07742084,0.036378756,0.05003594,0.15161999,-0.026321884,0.046339046,-0.03491203,0.04018661,-0.081111506,-0.13745357,0.018535176,0.08472597,-0.047993634,0.019882035,0.011154064,-0.0028494163,0.1019424,0.014176747,-0.053419802,-0.031630233,-0.021286754,0.065968916,-0.0395199,-0.09347457,0.021745268,0.018775636,-0.09473783,-0.005010779,0.028152201,0.006630304,0.026716422,-0.029075047,0.08099188,0.020717755,-0.02363742,0.09174562,0.04884162,3.6963794e-34,0.10005421,-0.0403637,0.11649939,-0.102562234,-0.06178033,0.04617695,0.013335467,-0.021523193,-0.037340097,-0.051284682,0.0016816922,-0.01649586,-0.07071094,-0.05902667,-0.016794575,-0.0868245,-0.009042638,0.027753139,-0.020601371,0.0077206297,-0.008038489,0.061390053,0.025313428,0.09688433,-0.03942421,-0.001845453,-0.008894549,0.11453682,0.013477973,0.011493035,-0.04116434,0.05136296,0.028330078,-0.0006136923,-0.07009961,0.022448458,-0.0141377775,0.082995415,-0.022045655,0.02992211,0.051391393,0.06053154,-0.026603999,0.029928513,-0.0063798768,0.12685071,0.006436873,0.049249616,0.068245836,-0.008070301,0.014766,0.03937346,-0.052332822,0.0010344163,0.05413908,0.07831891,-0.04022883,0.010560363,0.028452529,-0.08435053,-0.059423994,-0.08865332,0.08675555,-0.045649145,0.014883062,-0.025744991,-0.014819975,-0.068692744,-0.038430125,0.08189509,0.0797405,0.055153817,-0.04849041,0.026205579,0.009469664,0.05251858,-0.0380105,-0.08301518,-0.052690648,-0.014232276,-0.023176186,0.05238509,0.0267108,0.026221238,0.06910025,0.028123872,-0.013171287,-0.0018134019,-0.009010226,0.073696546,0.026384812,0.0057040714,-0.026981428,0.044417426,-0.0074064117,-2.9572542e-08,0.034889944,0.007630101,0.057299107,-0.07804646,-0.024131788,0.045562007,-0.01809017,-0.017814526,0.15841886,0.019128283,-0.047938712,0.061076313,0.043692164,0.07718562,0.09166634,0.019619297,-0.053596407,-0.0014193774,-0.011326371,-0.038496908,-0.03366887,-0.06607457,-0.056357097,0.073099464,0.016297292,-0.06015069,0.025671512,0.0517863,0.008475668,-0.07526817,0.027981322,0.00808498,-0.018842526,0.025263496,-0.0048856903,0.050077613,-0.04119485,-0.042175967,-0.072620295,0.054472435,-0.033298112,-0.08422356,-0.06762869,0.02710034,0.031118214,0.03534869,0.023595527,0.03809228,0.02018056,-0.018073969,0.047407474,0.023429848,-0.030662527,-0.095909685,-0.0721144,0.008818292,-0.0628328,-0.03258525,-0.026115423,-0.023327522,0.014493714,-0.03014367,0.16546021,-0.063388735 +3.6.3.46,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports some heavy metals, especially Cd2+, from the cytosol into the vacuole.",384,1.0,-0.030698303,-0.028624266,0.011166806,-0.015601726,-0.058365818,0.013171306,0.06658265,0.03431069,0.022690678,-0.038454283,0.007380815,-0.05207399,-0.040177498,0.04800174,-0.05822817,-0.098792605,-0.019034605,0.015012832,0.04180909,0.013375817,0.094923414,0.06093441,0.013547711,0.019678224,-0.049865197,0.0032540844,-0.020906758,-0.0289295,-0.01807915,-0.046645917,-0.1330899,0.021695599,-0.028998649,0.0155854765,0.037937123,0.084079385,-0.026950574,0.027465954,0.029189888,0.005908834,0.113945544,0.027343735,0.07102579,0.11415587,-0.11068959,-0.021234004,0.058174442,-0.011670163,-0.004079634,0.02144289,-0.021618754,0.00010424214,-0.024373723,0.029748697,-0.041839764,0.0017245889,-0.017595127,0.021890147,0.013650999,-0.022936512,-0.029047143,0.011387707,0.043551832,0.07597419,0.07389564,-0.031333067,-0.032779787,0.021594342,-0.022812992,-0.049972646,-0.078147545,-0.05500639,-0.09179857,0.047812853,0.057308663,0.01305231,0.024295555,-0.053617526,-0.047553647,-0.027322067,0.018082246,0.0044391924,-0.016773494,-0.03132841,0.045712188,0.016414745,0.021506434,0.029923895,0.012050199,0.024072351,-0.013155584,-0.0024022865,0.030447677,-0.0069657704,-0.0904846,0.024836542,0.032333273,0.06392495,0.029337298,-0.0051485174,0.084044784,0.0862176,0.07328839,0.0034759026,0.049847282,0.022101615,-0.0064858464,0.0016253409,-0.009923946,0.02123402,0.002480566,0.021037526,0.010762462,-0.07537887,-0.0029545487,0.050258968,-0.059627067,0.013059588,-0.08481684,-0.023661988,-0.043115698,-0.10973608,-0.03223014,-0.04926331,-0.034478962,0.02801925,-0.043374546,-1.04900785e-33,-0.091389894,-0.065451704,0.029911606,-0.012917841,-0.024890833,-0.0022053903,-0.027334077,-0.02186216,-0.06209352,-0.048165035,-0.0033701025,-0.00355643,-0.033764698,0.10441212,-0.025739033,-0.016982438,-0.03683873,0.035528954,0.10870595,-0.019249914,0.038587928,0.06489131,-0.036414173,-0.024526257,0.081091285,0.023929987,-0.027991107,0.023535948,0.048585173,-0.010649534,0.024722226,-0.06146901,-0.08551266,-0.031081777,-0.0015989562,-0.05580468,-0.022309747,0.013662634,0.07238638,-0.08722223,-0.093759224,-0.018645499,-0.046409067,0.06606683,0.046269283,-0.047130015,-0.044607136,0.047740214,-0.040652428,0.032077767,0.03278394,-0.1115433,0.13139458,-0.029009093,-0.01182676,0.027074968,-0.0036112226,0.06332577,-0.037456322,0.06886935,0.058463518,0.1530261,-0.03607898,0.04710654,-0.029762153,0.009510744,-0.09335314,-0.11639401,0.059048627,0.09116495,-0.028692028,0.058963336,0.030896911,0.0068347477,0.08032824,0.00040214666,-0.04970116,-0.06781957,-0.016886996,0.065233774,-0.03917643,-0.09385624,0.029114911,0.02346839,-0.07225649,-0.04241663,-0.034938682,-0.012166394,0.017625283,-0.04280156,0.10061903,0.0434556,-0.027122801,0.09464113,0.03964086,-6.158239e-34,0.11186929,-0.007030121,0.12042401,-0.109261245,-0.055122256,-0.013336143,0.010364838,-0.029174898,-0.03867879,-0.04327526,0.015460263,-0.0041881716,-0.059451327,-0.04282138,0.011976673,-0.071700744,-0.03402734,0.07745889,-0.0038844128,0.013003052,-0.012251338,0.052415792,0.013966395,0.09520115,-0.02182586,-0.032331742,-0.023603026,0.11097418,0.0065317466,0.014989704,-0.03436833,0.059771296,0.04096623,-0.025048131,-0.08655824,-0.012490106,0.019868845,0.056742493,-0.018215887,0.032160353,0.041280378,0.05749106,-0.017579895,0.03347867,0.0054690656,0.11220693,-0.016162701,0.04651166,0.045645475,-0.0142126875,0.015722932,0.034265455,-0.043417335,0.009101372,0.10543442,0.09099255,-0.02175973,-0.008692587,0.015762856,-0.076992534,-0.066974565,-0.074412465,0.08761998,-0.04036959,0.021676999,-0.010322785,0.005307932,-0.061565086,-0.049441785,0.082133494,0.10132269,0.087799944,-0.031179471,-0.02249896,0.0072169504,0.0139140645,-0.009118435,-0.0548133,-0.0632783,-0.023647921,0.003725517,0.07283267,0.027252162,0.0015066799,0.051903952,0.0076183258,-0.031692307,-0.0049090907,-0.02504589,0.07201351,-0.006418423,-0.047209326,-0.0052628415,0.046617206,-0.059453256,-3.2826147e-08,0.014731535,-0.0017067619,0.0430683,-0.122164376,-0.01768282,0.05329001,-0.01743396,0.005486363,0.116530865,0.028374942,-0.053426947,0.06059673,0.020317035,0.04806364,0.10407012,0.0653563,-0.04131991,8.086885e-05,-0.020950466,-0.03922273,-0.026993424,-0.04814905,-0.033207882,0.12635168,0.0059736967,-0.042920403,0.01552174,0.035848424,-0.029075107,-0.052310202,0.0007607713,0.0118736345,-0.03005237,0.010462012,-0.038657192,0.011716558,-0.040539503,-0.034442663,-0.07853724,0.042739164,-0.028516524,-0.07873691,-0.029894881,0.0018880789,0.036594648,0.0018598728,0.0076110414,0.051017404,0.019825682,-0.044061173,0.042107943,0.0077157067,-0.060715094,-0.0787817,-0.08342245,0.0065903547,-0.057928443,-0.019581497,-0.021195238,-0.014322632,0.06068905,-0.03286985,0.16281714,-0.048753124 +3.6.3.47,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome.",384,0.99999994,-0.07417338,-0.026132943,-0.012075184,0.015796557,-0.082893886,0.026300207,0.019953063,0.055423364,0.067122735,-0.068611145,0.039219227,-0.0766153,-0.0375656,0.075285606,-0.04916829,-0.06655761,-0.057192355,-0.025649663,0.04897891,-0.041118484,0.029628096,0.0992257,-0.025725238,-0.0047196196,-0.047850173,-0.046129096,-0.0044049784,0.0030448756,-0.004075371,-0.013496657,-0.09206379,-0.027614474,-0.015516501,0.019793618,0.019834185,0.07285698,-0.019084381,-0.017608663,0.03529319,0.02099971,0.11475398,-0.021915982,0.038063057,0.11556376,-0.12916778,-0.029026873,0.02087477,0.0066988454,-0.010006485,-0.00026706405,-0.04390443,-0.047152326,-0.065408945,0.04399678,-0.02990426,0.030687658,-0.016429273,-0.013559534,-0.03344298,-0.016339187,-0.036975194,-0.003175137,0.037207127,0.08382859,0.05013243,-0.01842656,-0.018177904,0.004409884,-0.016937539,-0.08425609,-0.059841707,-0.100325316,-0.047202263,0.048444096,0.045971025,-0.000100569705,-0.04894064,-0.061639182,-0.023328675,0.0069584707,-0.0016576718,-0.00056418986,-0.009658384,-0.005383122,0.057890087,-0.04703397,0.021412445,0.0015364159,-0.028337589,0.013767025,-0.024771692,-0.055737108,0.0023642788,-0.010826329,-0.058294322,0.028583363,0.037523173,-0.0027060013,0.008633315,-0.020348076,0.057463333,0.097588934,0.044953365,0.023224765,0.020487705,0.027409192,-0.0070666913,0.02557143,-0.012661349,0.0042069606,-0.012516474,0.014799083,0.06111793,-0.048222553,0.016755411,0.043945644,-0.05408668,0.014445058,-0.036141057,0.04147479,-0.0859663,-0.07773336,-0.010364071,-0.021727618,0.04558693,0.020948809,-0.08669687,-9.878197e-34,-0.04933808,-0.029473785,-0.00052915205,0.03539544,0.018448211,0.009273192,-0.051671866,-0.0030817057,-0.029634302,-0.06600233,0.047814243,-0.029469574,-0.013608116,0.07792542,-0.030049779,-0.026794534,-0.043270867,0.049490795,0.079639435,-0.024674837,0.03296602,0.059882026,0.0079228915,-0.07574313,0.059353154,0.0666354,-0.0630661,0.03588631,0.06238517,0.022629857,0.011227795,-0.05338235,-0.13062684,-0.04181117,-0.019577228,-0.030791098,-0.027192997,-0.01349998,0.029038763,-0.02995776,-0.063570485,-0.027603548,-0.056473628,0.0041834638,0.040078383,-0.031189015,-0.048812952,0.07890106,-0.04098374,0.025077077,0.06547747,-0.121773995,0.09264121,-0.04280226,-0.034589607,0.009109982,-0.0339912,0.029856343,-0.07276645,0.030244306,0.09322874,0.14548251,-0.041496243,0.055929903,0.0070424806,-0.00044630433,-0.11084279,-0.11003798,0.002356129,0.1268883,0.01857683,0.022653433,0.04635997,0.027627574,0.047635388,-0.016938755,-0.015772982,-0.006397253,-0.042671647,0.020940738,-0.023690464,-0.060037725,0.088605106,-0.012780706,-0.04962508,-0.045161612,-0.011727101,0.007876253,0.029828547,-0.0334233,0.118128,0.057574436,-0.04588574,0.092741944,0.023421168,-6.185803e-34,0.07263791,-0.039200865,0.110157825,-0.18091474,-0.018938912,0.010711939,0.047447734,0.04401365,0.015312444,-0.0521253,0.050226595,0.041802794,-0.05531928,-0.0721813,0.017394321,-0.035285883,-0.010424955,0.030407205,0.018978154,0.01337065,-0.021925174,0.01348608,0.0021395562,0.11286586,-0.02873675,-0.00026008536,-0.022645703,0.08460305,-0.019054603,0.00074488274,-0.008593691,0.048515003,0.012478441,-0.0481809,-0.072374,0.014064601,-0.033017933,0.10645621,-0.047189288,0.013806168,0.052352995,0.063393645,0.0024071662,-0.0031122372,0.022284165,0.07072694,-0.00029219865,-0.047781143,0.03954405,-0.036056772,0.00054027216,0.011166572,0.00053708896,0.0036702743,0.06671163,0.12430436,-0.023522427,-0.020237207,0.027375052,-0.116561815,-0.057942666,-0.058994427,0.054248735,-0.040686876,0.038508616,-0.01990191,0.0003109806,-0.09013124,-0.020527793,0.08495715,0.09894669,0.1071421,-0.07024897,-0.020057928,0.018669577,0.05403686,-0.021812893,-0.037458137,-0.07965806,-0.026935525,-0.029589614,0.06003755,-0.0040965364,-0.011116944,-0.009246372,-0.01330679,-0.031328764,0.0271163,0.019817213,0.031653337,0.00842631,0.014484446,-0.025549954,0.015879296,-0.006709094,-3.3182683e-08,6.0441605e-05,-0.04823234,0.03538101,-0.06673586,-0.029349025,0.05966125,-0.042442862,-0.024340957,0.11213939,0.03433557,-0.056619387,0.11636607,0.05450838,0.07773204,0.068674944,0.0346374,-0.034924194,0.0016301734,0.008182322,-0.032603137,-0.061973386,-0.034098614,0.0018268105,0.10359597,0.0059783803,-0.04289805,0.020977776,0.07790029,-0.026499404,-0.035765097,0.021629531,0.030528875,-0.00049298484,0.012243284,-0.024635574,0.0024004623,0.042769544,-0.045163974,-0.1079515,0.076388545,0.06016611,-0.036310345,-0.04575742,-0.0016209126,0.07887728,0.005644959,0.011085547,0.046845455,0.016899096,-0.015221909,0.048800647,0.03079092,-0.07453176,-0.03266971,-0.05639053,-0.034763347,-0.06747771,-0.03171665,-0.03600416,-0.00065373647,0.076973625,0.015615064,0.1883431,-0.06023632 +3.6.3.48,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports the alpha-factor sex pheromone.",384,0.99999994,-0.024158254,-0.046702534,-0.0048938743,0.0018786644,-0.049209934,0.06177769,0.055305034,-0.0053979764,0.04415185,-0.028107444,0.017833805,-0.055476874,-0.086003274,0.08990536,0.0067220465,-0.04442057,-0.05055823,0.011110355,0.06044069,0.0019662052,0.08101989,0.03767002,0.011547171,-0.0057406556,-0.07344138,-0.021047017,0.006122741,-0.008553241,-0.043928776,-0.044269226,-0.112121545,0.05882031,0.026972191,0.007458211,-0.04261123,0.09356831,-0.04453645,-0.030023847,0.08827857,0.045153536,0.13216512,-0.013360525,0.054702684,0.1001671,-0.14290474,0.014878573,0.039348178,0.019946583,0.016220897,-0.0024325158,0.00990591,-0.060695983,-0.056190513,0.059588637,-0.037248865,0.029542463,-0.00021535672,0.006862735,0.0100727985,0.016954713,-0.044357214,0.03339265,0.022538487,0.08538451,0.081748284,-0.04377468,-0.053918503,0.0024433422,-0.02357911,-0.04442856,-0.054909017,-0.041489743,-0.10023809,0.050122764,0.066075765,0.049498763,-0.024031678,-0.024695536,-0.03893133,-0.039557565,-0.004257667,-0.0473495,-0.03800318,0.038744915,0.053490248,-0.04667143,0.023549916,-0.010822925,0.004032452,0.050727572,-0.058213178,-0.014140273,0.0119934175,-0.013475975,-0.07634156,0.025030006,-0.0036875233,0.05251137,-0.006361545,0.007223777,0.05718137,0.08921592,0.025192231,0.019043019,0.0022993607,0.039834306,0.005584949,-0.02666657,-0.018162834,0.030516239,-0.029837891,-0.029699393,0.050832566,-0.05957294,0.025783142,0.020676361,-0.04897044,0.018700069,-0.008873144,-0.013567618,-0.040192325,-0.07707748,0.028333185,-0.013743337,-0.024677288,0.022365142,-0.06269769,-2.1350864e-33,-0.060126748,-0.022851828,0.014594162,0.009004,-0.031641316,0.039590187,-0.002899663,-0.05071194,-0.051354848,-0.09435449,-0.007037643,0.048648056,-0.04017829,0.06797387,0.0068449276,-0.020897519,0.014885949,0.03396273,0.04877577,7.130329e-05,0.034181092,0.07980367,-0.040107325,-0.066424824,0.090560764,0.018392688,-0.058868054,0.030115178,0.025664771,-0.011972255,0.006581026,-0.04206554,-0.12624416,0.004734402,-0.013073117,-0.06325518,-0.03018458,-0.025532868,0.057815257,-0.07909743,-0.09841838,-0.043169744,-0.039519403,0.02420105,-0.008164798,-0.055424217,-0.03813863,0.04169072,-0.013445947,0.027928248,-0.0008566085,-0.103171006,0.1261884,-0.0232922,-0.042417977,-0.0001641102,0.0034711964,0.012923791,-0.079847366,0.043642133,0.05708308,0.13314094,0.0077523184,0.042750753,-0.06578364,0.013815491,-0.07464898,-0.13334246,0.02434559,0.1109963,-0.0057409205,0.051385812,0.041602284,-0.004840954,0.0713368,0.014884096,-0.037199102,-0.04449955,-0.03631644,0.02442616,-0.015933657,-0.094866976,0.04751702,0.052934326,-0.07705283,-0.051002696,0.017810067,-0.0025393388,0.016684923,-0.041051533,0.07229064,0.0030179867,-0.010695299,0.08951603,0.059983674,9.381147e-34,0.07057805,-0.041901223,0.10895076,-0.12759683,-0.06359431,0.035112992,0.06118174,-0.031601507,-0.04189338,-0.0132502895,0.019029396,-0.018573882,-0.05520493,-0.07610221,0.029239666,-0.08314335,-0.026122719,0.07824512,0.022086082,-0.0076106205,-0.0119400155,0.07092886,-0.005162877,0.10431312,-0.020453267,-0.016871737,0.04075704,0.1187284,0.010129052,0.024497122,-0.050287616,0.04865881,0.005481885,-0.015654337,-0.022464452,0.013888123,0.013738076,0.06272197,-0.013163737,0.028453426,0.0339831,0.08920066,-0.015092142,0.0119498735,0.03025034,0.12352772,0.020769197,0.079791,0.046832707,-0.0002863945,0.011696545,0.0053299996,-0.055949192,-0.03448924,0.029694784,0.0871468,0.003945474,0.016633263,0.008400686,-0.054625735,-0.048368692,-0.07364278,0.06389373,-0.025533207,-0.03862562,-0.029745733,0.008768948,-0.061598837,-0.018799568,0.12747778,0.10996281,0.08982445,-0.02108745,0.03578765,0.021981513,0.027144916,-0.017288348,-0.056533836,-0.026413467,-0.0135141,-0.0038087978,0.047924433,-0.00050900254,0.022477655,0.0421711,-0.012526668,-0.004771268,0.013336281,-0.034845084,0.05439995,0.015854418,-0.0096327625,-0.035319947,0.044625,-0.010972787,-2.9938814e-08,0.022970453,-0.011217233,0.022209717,-0.09854462,0.011057108,0.044641506,-0.052452996,-0.05188195,0.13786273,0.006262983,-0.061055053,0.060529247,0.048243657,0.058687117,0.10151782,0.025233341,-0.011125592,0.009699674,-0.017769758,-0.036921397,0.009693165,-0.046347152,-0.08792194,0.07637393,0.014266762,-0.023599997,0.03918539,0.07070325,-0.019739492,-0.051321443,0.050025236,0.0030577749,-0.016801918,-0.01004763,-0.02176853,0.07558721,-0.022892628,-0.030592998,-0.0706674,0.023534717,-0.0021025306,-0.08502236,-0.051159367,0.0071485653,0.045678206,0.04477965,0.047059476,-0.0017024445,0.017779365,0.023176646,0.02109512,0.060713165,-0.044901695,-0.097310066,-0.08525807,-0.05086318,-0.06041814,-0.05469086,-0.006285132,-0.024550501,0.068600036,-0.03466368,0.16528675,-0.08404476 +3.6.3.49,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.",384,1.0,-0.025083097,-0.0559828,0.013746453,-0.011982037,-0.09885599,0.022682332,0.07311742,0.044106428,0.08012469,-0.042874627,0.008075298,-0.030518329,0.0089797275,0.13519798,-0.04641688,-0.077611655,-0.077219255,-0.020049943,0.02028817,-0.008241567,0.04501631,0.086006016,-0.032652177,0.008703246,-0.0778979,-0.014258271,0.03958724,-0.011050103,-0.016023,0.010689318,-0.16646901,0.020529216,0.0232417,0.044160355,0.03702851,0.06632331,-0.060426645,0.0048770173,0.04891971,0.03509416,0.098300405,0.0027807767,0.080262035,0.10114713,-0.08140547,-0.007619259,0.019683711,-0.008975148,-0.014459289,0.0019512189,-0.021329178,-0.020013047,-0.045189116,0.07212444,-0.036159463,0.009096141,-0.075373486,0.005696065,-0.019097237,-0.033316284,-0.0075680455,0.034897752,0.039614096,0.08973579,0.06712732,0.0074627483,-0.017346736,-0.006942884,-0.0010836574,-0.068551295,-0.07548096,-0.08533065,-0.031094022,0.040941685,0.06998438,-0.0416895,-0.010860519,-0.01837017,-0.054794066,-0.013570271,0.018416807,-0.027554346,-0.053043414,-0.010972861,0.038742814,-0.0051365183,0.05197799,-0.02173673,-0.010872915,0.018540809,-0.041452274,-0.026647815,-0.016097069,-0.03441315,-0.08166131,-0.0036057897,0.022962868,0.035871826,0.013827274,-0.0015864352,0.068352014,0.06268141,0.07882943,0.011831292,0.027451554,0.0017083521,0.028131122,0.01730291,-0.02303314,0.00751044,-0.048043467,0.020673143,0.025030002,-0.061485447,0.021001264,0.102275625,-0.03703036,0.0058383355,-0.039587494,0.042464867,-0.023605725,-0.1298033,-0.012416181,0.011981842,-0.012518447,0.056735534,-0.09497488,-1.1820864e-33,-0.053653054,-0.06688033,0.047560535,0.0042640767,-0.026750542,-0.011212557,-0.025031433,-0.05392671,-0.033866256,-0.07822462,0.019994609,-0.012760224,0.0030456218,0.02364044,0.009148922,-0.022441985,-0.100247286,0.0064366995,0.087910354,-0.015432073,0.04504475,0.060668994,0.009432999,-0.04482152,0.07691175,-0.0015440779,-0.051859815,0.02651321,0.09208083,0.012008067,0.012264378,-0.063387565,-0.10175392,-0.010341827,-0.044479743,-0.055129588,-0.051413056,-0.0005431785,0.09705406,-0.047524165,-0.07220371,-0.06507717,-0.03287276,0.016888129,0.07442684,-0.070141375,-0.058312103,0.06834918,-0.058060728,0.03245605,0.08421836,-0.11877581,0.05223462,-0.07558395,-0.0012484735,-0.028172886,-0.0106464615,0.02744847,-0.11289347,0.06076571,0.10372055,0.117996864,-0.041452285,0.01405544,-0.0133243045,0.019850466,-0.08101616,-0.100368254,0.012149865,0.053358264,-0.019984527,0.023765516,0.009867374,0.017052868,0.041676152,0.008047443,-0.014696768,-0.0006018768,-0.03315796,0.045851726,-0.015390378,-0.057224814,0.064073026,0.07210984,-0.05408125,-0.043499384,0.024335258,-0.028392537,-0.0013584077,-0.0511715,0.10713887,0.081181645,-0.058571175,0.08953568,0.09094648,-5.852203e-34,0.04687324,-0.03326801,0.07092536,-0.09116498,-0.043163728,-0.023725705,0.017105117,-0.021101546,0.011546455,-0.044716936,0.015612333,0.01251012,-0.052780513,-0.0471746,0.0013684708,-0.07261014,-0.029692909,0.02746079,0.0046977666,0.014418117,-0.009299115,0.022232948,0.0335846,0.054241095,-0.07304227,0.013535581,-0.05316193,0.10720896,0.003496282,0.019900111,-0.027978323,0.056030784,0.024470301,-0.008791865,-0.08146658,-0.01290717,0.008382458,0.03213176,-0.014812823,-0.019966947,0.028430585,0.06320881,0.033552,-0.007594735,0.0040635634,0.120980956,0.08282913,-0.027357025,0.008436267,-0.021900449,0.026301844,0.047013227,-0.025154693,-0.006984682,0.03980708,0.13643454,-0.010697963,0.014315755,0.033919897,-0.09018772,-0.049260892,-0.046870016,0.06563441,-0.07401136,0.02815403,-0.052908964,-0.004759276,-0.03884834,-0.0030129054,0.074388094,0.10540702,0.097363874,-0.0706643,-0.025801819,0.013544308,0.07308168,-0.011278931,-0.039481916,-0.061007194,-0.0014622165,-0.03739699,0.084016904,-0.028166993,0.01752204,0.031256407,0.011381891,-0.022423584,0.0052055637,-0.01346361,0.03682121,0.026414087,-0.0032211076,-0.0055296742,0.06878098,-0.013979826,-3.466181e-08,-0.013488223,-0.03461055,-0.028391011,-0.09548337,0.006628722,0.06164534,-0.040702853,-0.023433173,0.1247224,-0.0076197614,-0.038021196,0.04565697,0.026458163,0.06900798,0.09158017,0.051392026,-0.076093584,0.004853603,-0.0021366957,-0.0429427,-0.04020853,-0.082818724,-0.064028606,0.121093795,-0.0055615515,-0.06001664,0.021392314,0.06810175,-0.058451552,-0.045364838,0.009107812,0.018662719,-0.012698429,-0.008547809,-0.06345763,0.023655603,-0.009996648,-0.020876963,-0.09463988,0.09451544,0.041567296,-0.051613215,-0.06349089,0.013901951,0.08158349,0.035445716,0.03187137,0.026533732,0.016816491,-0.026219537,0.010753328,0.01663968,-0.019943904,-0.06711599,-0.04902865,0.021050712,-0.044856753,-0.0230275,-0.004681857,-0.0022697523,-0.004227549,0.03160088,0.12883903,-0.022030149 +3.6.3.50,"A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. There are several families of enzymes included here, e.g. ATP-hydrolysing enzymes of the general secretory pathway (Sec or Type II), of the virulence-related secretory pathway (Type III) and of the conjugal DNA-protein transfer pathway (Type IV). Type II enzymes occur in bacteria, archaea and eucarya, whereas type III and type IV enzymes occur in bacteria where they form components of a multi-subunit complex.",384,1.0,-0.037760302,-0.06350186,0.012327987,-0.027291697,0.012670718,-0.033017218,-0.02630009,0.021503922,0.067050785,-0.053620268,0.05159636,-0.059829004,-0.021727368,0.07120387,-0.015925521,-0.075991094,-0.06630858,0.033877205,0.026077446,-0.041144546,0.06842409,0.0639101,-0.027377762,0.024514422,-0.04257091,-0.0026156032,0.025569638,-0.015644094,-0.005470788,-0.043933295,-0.13551877,-0.052709647,-0.031149948,0.01599508,0.049915574,0.075792395,-0.07438278,0.024052896,0.08853118,-2.9610912e-05,0.104666665,0.032342862,0.07580304,0.05832489,-0.08583744,-0.034247845,0.003230596,-0.0060659293,0.016722683,-0.041235093,-0.05827992,-0.04287482,-0.04302293,0.0786338,0.014686093,0.02011573,-0.039095666,-0.034679737,-0.043447826,0.03506146,0.045197975,0.026922315,0.04566763,-0.018238228,0.023467444,-0.024680147,-0.006195066,0.016069274,0.048966467,-0.043755762,-0.0799122,-0.07088429,-0.062764846,0.036247455,0.014930655,-0.015734153,-0.03601768,0.054778833,-0.03421076,-0.069512516,0.02074109,-0.043088347,-0.004236824,0.052905004,0.046384685,-0.035078492,0.03636242,0.004413828,0.029515887,0.03742345,-0.059312917,-0.0714177,0.06708784,-0.040552724,-0.046540704,-0.026053622,-0.008055485,0.02931126,0.020345546,-0.013032139,0.04674743,0.024375318,0.029112922,-0.028827146,0.0105762975,0.03337205,-0.021591756,0.004401366,-0.008645115,0.057566267,-0.02607242,0.052159514,0.025230046,-0.06531442,-0.008836222,0.0824405,-0.040090647,0.006502108,-0.020428032,0.042607095,-0.00016508995,-0.077281795,0.037941273,-0.014774561,-0.07454251,0.01686233,-0.07435848,-6.393561e-34,-0.06857463,-0.057735223,0.017939746,0.018515643,-0.03744377,0.013659784,-0.03705424,-0.027621692,-0.050561428,-0.04281374,-0.02045152,-0.07917791,0.015656278,0.053657968,-0.0035086805,-0.019760147,-0.04516023,0.03056867,0.04262802,-0.040923472,0.074586794,0.10124485,-0.0012780451,-0.042925972,0.085588746,-0.0064051007,-0.0025662952,-0.007927154,0.048136726,-0.002497366,0.053701904,-0.15155709,-0.077716365,-0.0057086004,0.03428369,0.00064869487,-0.038285885,-0.05127811,0.065209016,-0.046368953,-0.07264177,-0.015203801,-0.028528642,-0.01340907,0.0726733,-0.05581665,0.00029319443,0.06181958,-0.027541408,-0.0007205251,0.026454188,-0.11477996,0.054280646,-0.07422795,-0.046437364,-0.048599485,0.055526897,0.08264002,-0.0016744777,0.06323397,0.051933415,0.07634116,-0.05569512,-0.014214027,-0.024476498,0.066684045,-0.09793198,-0.07758375,0.058503203,0.11652092,-0.06985682,0.018402072,-0.004882531,0.049113136,0.058687575,-0.034808565,-0.10449131,-0.047192175,-0.0030832884,0.0686506,-0.10926552,-0.053666193,0.06492379,0.067904666,-0.0766546,-0.024677806,-0.056618396,-0.013618924,0.0492642,0.008361968,0.13470021,0.053892966,-0.05280987,0.10148385,0.040473446,-1.8264644e-33,0.070667565,-0.02637997,0.07330652,-0.1342353,-0.048497003,0.03949926,-0.020493105,-0.0042188675,0.045828406,-0.012224922,-0.006638714,0.007012232,-0.00914376,-0.072844215,0.013184857,-0.06313247,-0.013530733,0.080534644,0.01393429,-0.008425511,0.033449385,0.037278228,0.025070444,0.04540078,-0.038730413,0.017872507,-0.045446157,0.15468402,-0.029906932,0.04835921,-0.06576432,0.07093348,0.022225015,-0.012713565,-0.08116152,-0.02586585,0.0036273235,0.024857054,-0.025400402,0.0019729978,0.020387178,0.108717896,0.08404099,0.016778337,-0.0371623,0.10209926,0.009774758,0.03492954,-0.0220831,-0.009589323,-0.0018836285,-0.03779582,-0.033954646,0.009621874,0.046493705,0.080999635,-0.04056507,0.028023684,-0.0023659673,-0.006861887,-0.048389513,-0.09481921,0.055879742,-0.0073935636,0.035145517,-0.04077725,-0.050350454,-0.0029663634,-0.00845225,0.01972846,0.025572618,0.064490624,-0.037140526,-0.04036408,-0.006587668,-0.029598938,-0.042497464,0.029016027,0.024114002,-0.048399247,-0.0015582173,0.044953115,0.00029203805,-0.007903218,0.07433734,0.0055851447,-0.0061325254,0.038461413,0.021391867,0.053862024,-0.0276575,-0.001301448,0.0007620943,-0.0053532603,0.033331662,-4.0585576e-08,0.054873124,-0.024862804,0.055145472,-0.051614504,0.0017349909,0.04397874,-0.07366361,0.065525785,0.083469436,0.08778831,-0.03150088,0.01684061,0.04707059,-0.042783506,0.029554734,0.0868515,-0.036475964,0.03279666,-0.041763276,-0.034991276,-0.00441852,-0.05983556,-0.08746453,0.10769767,0.02017073,-0.010660241,0.025849342,0.024040386,-0.038952015,-0.0595243,-0.015291496,0.016760206,0.016615456,-0.022472514,-0.097320504,0.044273894,-0.015206944,-0.043560535,-0.07158286,0.037189998,0.04828298,-0.0763541,-0.076972075,0.009988643,0.085938945,0.06440394,0.010213554,0.025016923,-0.028149169,-0.030496085,0.04151184,-0.015116864,-0.0013867574,0.0075653144,-0.077498965,0.020248933,-0.035159413,-0.06580379,-0.023580343,-0.010446514,0.09820996,-0.0071325456,0.22154824,-0.055776093 +3.6.3.51,"A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. (TIM is the protein transport machinery of the inner mitochondrial membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.)",384,1.0,-0.1039494,-0.008502393,0.0033181075,-0.0003636852,-0.007983335,0.013449118,0.020362202,0.00031533666,0.013826673,0.022437694,0.089231975,-0.035454847,0.034713343,0.018629918,-0.02583219,-0.021865485,-0.034764297,0.036192607,0.04203064,-0.02322277,-0.02036047,0.046407364,-0.022967122,-0.018957114,0.036940277,0.02877356,-0.036136102,-0.012401969,-0.016494932,0.045715563,-0.15817812,-0.024126217,-0.018843276,0.009102882,-0.030534498,0.12937452,-0.08424845,-0.021544352,-0.022687353,-0.025676098,0.1525173,-0.031412788,0.066416755,0.05326195,-0.036009267,-0.04318668,0.029412832,0.0341308,-0.054724667,0.015041013,-0.07355694,-4.3512664e-05,-0.034263086,0.08781989,-0.025482368,0.05670978,-0.05116453,-0.014161132,0.00043965055,-0.032615654,-0.0069008037,0.019653736,-0.046774216,0.0044190073,0.07565741,-0.089838974,-0.004923166,0.025136247,0.038911574,-0.049414594,0.026027696,-0.035134,-0.050750818,0.04815859,0.040611506,-0.008584604,-0.034718473,0.040957514,-0.015545452,-0.011602246,0.06297978,0.00882204,0.056154523,-0.031949945,0.07018979,0.059096243,0.055180825,0.06811927,-0.0238396,-0.0021769323,-0.05067059,-0.032882173,-0.03828436,0.010556917,-0.12309992,-0.015984124,0.037502225,0.051197574,-0.045973454,0.0076179225,0.059935343,0.06793961,-0.0003632271,-0.012535864,-0.013117745,0.0008039134,-0.030030163,-0.030547434,-0.012464917,0.041199174,0.0353033,0.025197344,0.031931505,-0.060311824,0.03602488,0.100908734,-0.049559895,-0.0011233469,0.0543394,0.070412785,-0.04041407,-0.05990252,-0.019904545,0.035981927,-0.019469617,0.01662168,-0.052750286,1.1367208e-33,-0.0145368185,-0.05495019,0.034075834,0.041322935,-0.034444075,-0.06587725,-0.085658185,-0.0590184,-0.007920168,-0.10020614,-0.0013161427,-0.0015286492,0.01974089,0.024993334,-0.040423367,-0.08048141,-0.058663312,0.016541323,0.18096143,-0.07117362,-0.047612425,0.11079177,-0.018490227,-0.07257037,0.038334526,0.024454823,-0.06361047,-0.038420785,0.07052174,0.040139973,-0.05360762,-0.059875943,-0.12750286,-0.0345775,-0.05301056,0.0033168187,-0.060366657,-0.12624818,0.020313762,0.03563047,-0.10854129,-0.043067276,-0.0498392,-0.047154706,0.024911607,-0.081734,0.0021348933,0.0045747245,-0.056991223,0.031645678,0.04883208,-0.0802012,0.055719662,-0.081542104,-0.11579141,0.042233944,0.043877013,0.025658054,0.0056224954,0.079182826,0.107096985,-0.008558449,-0.02346505,0.042292394,0.05425786,-0.017778058,-0.09466877,-0.07817131,0.07185995,0.10079278,-0.06686935,-0.027370721,0.06272942,0.002869583,0.057147272,0.054529816,-0.003097466,0.031893387,-0.045041356,0.021015529,-0.0064175837,-0.051215228,-0.008590922,-0.02180358,-0.016884593,-0.030764576,-0.0045671896,-0.021535695,-0.028774861,-0.042633716,0.09339157,0.07865952,-0.06375137,0.10017849,0.02032441,-2.373634e-33,0.10410301,-0.05817101,0.074553326,-0.05182264,-0.08747161,0.00042133644,0.057471327,-0.018149553,0.021081107,-0.025490196,0.05055779,-0.07932116,-0.04635157,-0.082376294,0.033419482,-0.04720324,0.012664535,0.04155713,-0.013384442,0.045165986,0.036772244,0.042012975,-0.028729783,0.10738851,-0.13470809,-0.028939502,-0.030006144,0.047391515,-0.012467827,0.0013540268,-0.018179132,-0.039159607,0.0010096036,-0.0014624647,-0.07078724,0.020879503,0.050359704,0.07362357,0.042327266,0.024936235,0.1002036,0.060365573,0.008324197,-0.020359917,-0.017439848,0.07410652,-0.0051946533,-0.033425078,-0.019953055,-0.023573939,0.081389405,0.0049681095,-0.05479033,-0.036985178,0.011637745,0.06885699,0.06501649,0.009317183,0.053401425,-0.06555268,-0.051913142,-0.0039824424,0.032126922,-0.042172994,0.03858408,0.085435025,-0.049648713,-0.06838202,-0.025862942,0.036275696,-0.026775952,0.05897386,-0.051349327,-0.045997616,0.035754684,0.0066417633,0.057293996,0.03328351,-0.0016558578,-0.06498025,-0.027116917,0.030315548,-0.00386802,0.0057438803,0.023213856,0.019347055,-0.009314151,0.008199081,0.07298761,0.02640804,0.048331495,0.030923752,0.01414603,0.038009603,-0.007607331,-3.5340538e-08,-0.007590735,-0.029223198,0.02082155,0.0018056447,-0.03634453,0.059049636,0.041221477,0.008792497,0.080145,0.06637835,0.03389804,0.04692153,0.008365401,-0.020742571,0.056074478,0.04660603,-0.056358226,0.014238606,-0.0218036,-0.07448164,0.023728358,0.015952133,0.018667012,0.13401368,0.03316686,-0.0020925323,-0.014641967,0.06631339,0.055611473,-0.10163001,-0.024735648,-0.0059816344,-0.032158777,-0.0046560983,-0.09443349,0.02802013,0.029975835,-0.0240864,-0.04566825,0.06820486,-0.0014693652,-0.07282924,-0.08459563,-0.040393088,0.018241279,0.04707975,-0.017674528,0.03336256,-0.029988699,0.02214513,-0.019717654,0.03828181,-0.0014252948,-0.059708,-0.06120494,-0.024816476,-0.03765506,-0.022210771,-0.031532507,-0.056958634,0.078645095,0.02213106,0.103679135,-0.031581577 +3.6.3.52,"A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. Involved in the transport of proteins or preproteins into chloroplast stroma (several ATPases may participate in this process).",384,1.0,-0.033424187,-0.028722344,-0.04012236,-0.011217812,-0.046288114,0.037283167,0.048953407,0.011040572,0.084305905,-0.06740045,0.03679494,-0.05521234,-0.0008107528,0.05921685,-0.06763935,-0.058893617,-0.033707008,0.059205715,0.0153823,-0.056618966,0.011238639,0.070148796,0.0022483957,0.04391108,-0.025441961,0.027451804,-0.04593085,-0.05770325,-0.0054585948,0.013329622,-0.14099084,0.015045063,0.021349823,0.025068533,0.017844884,0.14021406,-0.04269764,-0.038966034,0.022784224,0.023710037,0.10273209,0.041364633,-0.024579702,0.07838213,-0.08016201,0.0038926217,0.044963386,0.012119983,-0.07604424,-0.024162874,-0.05956747,-0.026988914,-0.09142647,0.04806683,-0.018543344,0.07915184,0.018789144,-0.041161638,0.02032229,-0.07421566,-0.019193973,0.0073111625,0.05399999,0.072758384,0.040609322,-0.091275856,0.015147029,0.06462606,0.02296379,-0.031117896,-0.011222584,-0.019921862,-0.035324603,0.06437505,0.02483974,-0.06807636,-0.0077474904,0.04415609,-0.015159246,-0.03399903,0.058189318,-0.017911037,-0.03304454,0.0026084855,0.076995865,-0.024128275,-0.032755826,-0.002618976,0.0074169766,-0.005307752,-0.059603903,-0.047133908,-0.025606515,-0.034779165,-0.08912583,0.0048856805,0.06328145,-0.011688216,0.00338933,0.026841268,0.07360181,0.075018026,0.049722325,0.00942566,0.006726535,0.006882394,-0.07337937,-0.022583406,-0.05091861,0.049743727,0.003270117,-0.020595359,0.024141656,-0.050949946,0.01594666,0.0805413,-0.016641025,-0.016800981,0.0078638755,0.03969298,-0.08812191,-0.07703786,-0.01613865,0.03362076,-0.042565968,0.06283694,-0.09092927,-1.541616e-33,-0.035943147,-0.08569774,0.031352106,-0.0040924456,-0.07139372,-0.00976785,-0.050867416,-0.0654456,0.019274944,-0.08418751,0.024946343,-0.01601303,0.032836843,0.04456915,0.0184546,-0.044845212,-0.059392065,0.09433608,0.12761162,-0.038133454,-0.01857251,0.07775936,-0.03157935,-0.040377386,0.03373981,0.009760987,-0.08564523,-0.046945058,0.07945849,0.011095139,0.004024521,-0.014116428,-0.04310131,-0.037896514,0.030442176,-0.079963975,-0.078875616,-0.0679081,0.03306691,-0.028322916,-0.10563849,-0.07377618,-0.044678997,-0.008108807,0.017769555,-0.077913694,-0.025218567,0.0072943633,-0.0644941,0.041903246,0.054244768,-0.10823528,0.07144973,-0.09926566,-0.08048057,-0.026488042,0.024131222,0.009802379,-0.043980684,0.052921914,0.066030085,0.11722783,-0.079707235,0.020504797,0.012129458,0.011285172,-0.1214093,-0.07775374,0.039684888,0.017377235,-0.062377267,0.0027258687,0.033029914,0.046370022,0.10494001,0.010633587,-0.05703667,-0.016931944,-0.043387745,0.048762053,-0.0061681424,-0.05146198,0.018114025,0.009167192,-0.049864992,-0.018772315,0.01326819,-0.008126534,-0.032870036,-0.035561025,0.118926786,0.054175477,-0.10473659,0.097261116,0.079918295,-1.7041795e-33,0.061037444,-0.050148446,0.08471817,-0.07713177,-0.03457721,0.011885263,0.008724892,-0.046342902,0.05278054,-0.03810007,-0.037057232,-0.0009279938,-0.053363066,-0.04232268,0.011448327,-0.03427095,-0.016134217,0.049984273,-0.031514812,0.057021197,0.027425183,0.019292893,0.00819488,0.101423524,-0.07693813,-0.014243985,-0.06847788,0.05698806,0.011748179,0.02406493,-0.00791836,-0.009245883,-0.009348258,-0.036000647,-0.10303761,-0.0015558616,0.057351287,0.05944729,-0.034032192,-0.005759803,0.052489497,0.09221365,0.056258094,0.019603316,-0.0033252425,0.10286754,-0.028842153,0.022932205,-0.031806964,-0.018480942,-0.01893673,0.055505693,-0.047378927,0.010216671,0.054389317,0.07646145,-0.04162995,0.014663273,0.07166217,-0.086497076,-0.036774155,-0.068060115,0.018932903,-0.029859057,0.043426473,0.015962223,-0.011564941,-0.008272086,0.008116149,0.04486705,0.03775056,0.08270888,-0.056822997,-0.065556906,0.036519896,0.0013726101,-0.015016776,-0.029218739,-0.019266468,-0.08042642,-0.07408976,0.067741014,-0.0067416243,-0.0018787947,0.06750943,-0.04858323,-0.02200341,-0.037342012,0.029776592,0.015111691,0.03471338,-0.0161374,-0.009053497,0.04616013,0.023460733,-3.100693e-08,0.030831087,0.00487977,0.0243897,-0.05158219,0.047701318,0.026989264,-0.0062206807,0.007905908,0.12384633,0.069728024,-0.0056865322,0.0034498554,0.037710506,-0.04904983,0.030183071,0.09658246,-0.053184286,0.031194165,-0.0051717735,-0.054144364,0.024264257,0.0051877783,-0.06893726,0.13873279,0.062087584,-0.04275871,0.072837204,0.037009418,0.006797499,-0.10586002,0.039523248,0.018366635,-0.0038306597,-0.018916123,-0.039043136,0.035032213,0.020875568,-0.013892713,-0.1071094,0.05006968,-0.03511039,-0.008272196,-0.06489602,0.017040739,0.020358559,0.06061566,0.006657974,0.030057034,0.009677524,-0.0062558358,0.039047677,0.0048169713,-0.025914194,-0.04662423,-0.078573786,-0.009280748,-0.0038695775,-0.04567767,-0.05897316,0.019615347,0.06680655,0.032017455,0.14784405,-0.013224118 +3.6.3.53,A P-type ATPase that exports Ag+ ions from pathogenic microorganisms as well as from some animal tissues.,384,1.0,-0.051657833,-0.035992544,0.060525443,0.023031147,0.042489305,0.015631754,0.03469856,0.07890591,0.06453201,0.05857212,0.02407719,0.0047328686,-0.025110876,0.07268457,-0.08097965,-0.090074874,-0.03973479,0.08281014,0.030640516,-0.058535777,0.063939184,0.0517419,0.03339794,-0.060615595,-0.02300699,0.04838367,0.0078107943,-0.037552405,-0.051331367,0.01565847,-0.096606426,-0.08832862,0.10869241,-0.06692037,0.019158747,0.057345767,-0.067509174,0.088953316,0.023300854,-0.06734989,0.1902886,-0.03612517,0.05078906,0.021102043,-0.023274962,-0.048835848,0.0167388,-0.043229807,0.07703107,-0.018125867,-0.07276927,0.02422808,-0.066093326,-0.0055323928,-0.0465877,-0.017111724,-0.02114417,-0.06405137,-0.071913436,-0.03430432,0.015132413,-0.00710693,0.022207195,0.033745307,0.020477964,-0.08009868,0.051221736,0.0787689,-0.0476946,-0.05191291,-0.07161039,-0.020651951,-0.048095826,-0.0056098555,-0.0042940234,-0.0015111207,-0.01821851,-0.018688885,0.062966436,0.039022326,0.08301429,0.035315022,0.0014480766,0.031544477,0.05504384,0.015775869,0.050982565,0.03978808,-0.000978414,-0.023147652,-0.04150954,-0.056042448,0.0069883615,-0.0101683615,-0.041024003,0.01789061,-0.008211135,-0.017495267,0.04895761,0.014704401,0.023811398,0.03421644,0.020699201,-0.06754817,-0.012941706,-0.013506538,-0.072125055,0.015794901,0.056177385,0.113686256,-0.022932673,0.029522136,-0.053475987,-0.065512486,0.03375136,0.085730724,-0.012009251,-0.06601817,-0.03399017,-0.02258043,-0.03657305,-0.05985306,0.019437423,0.08110918,0.041838262,0.031662583,-0.0036457053,-9.143189e-34,-0.019271677,-0.046884265,0.02495592,-0.019805029,0.029007766,0.03514552,-0.0629394,-0.009655758,-0.029625902,0.0040566456,-0.06459038,-0.069322444,0.049081128,-0.0083003575,0.042563472,0.0043954602,-0.03255305,-0.019963613,0.13744068,-0.03212691,0.010327444,0.00015082253,0.017055916,0.048910372,0.08012196,0.025778716,-0.020846995,-0.013616089,0.044767145,-0.038325567,0.04617546,-0.100476466,-0.074845985,-0.02561028,-0.0438435,-0.046528045,-0.14170372,-0.08497872,0.06486847,-0.023207178,-0.06992107,0.02357565,0.035706054,-0.00036467772,0.053899482,-0.055175647,-0.11319699,0.06022902,0.0041506463,0.08132833,0.040613636,-0.089224674,0.122617334,-0.018911678,-0.06418293,0.02436103,-0.028329736,0.046497207,-0.042613883,0.04094366,0.0786915,0.084391445,-0.019555824,0.0045029204,-0.021320187,0.04218696,-0.048180353,-0.012980037,0.008576331,0.07747081,-0.04413212,-0.0017866169,-0.06907868,-0.05910548,-0.015861096,-0.011859505,-0.019655911,0.028407846,-0.00536175,0.033421803,-0.023108983,-0.03393522,0.037674535,0.092739955,-0.07720025,-0.0062695374,-0.058626644,0.023427822,0.088512994,-0.05089597,0.08935969,-0.0011158339,-0.09998502,0.07311714,-0.03071045,-1.4444546e-33,0.061752163,-0.042911638,0.034564592,-0.057855636,-0.065888196,-0.00066300534,0.008978405,0.036898382,-0.014772178,0.030590389,-0.07362525,0.028563581,0.033744045,-0.0542479,-0.025552731,-0.053094663,-0.036409177,0.075740464,0.04416456,0.03474242,-0.009339421,0.08557956,0.074212626,0.031005092,0.031002257,-0.027661353,0.009108915,0.09454292,-0.015280697,-0.02108142,0.044391282,0.033634674,-0.04280778,-0.033717252,-0.06285044,-0.030104112,0.06913385,-0.010751748,-0.0336168,0.06475967,0.057597857,0.0769842,0.05932671,0.08305692,0.019698236,0.080106646,0.00045140547,0.00064394926,-0.008457771,-0.098590374,-0.03126346,0.03177976,-0.05674998,-0.044002406,0.017417986,0.013094537,0.062065173,-0.0103336945,-0.044555217,-0.08157249,-0.05614894,-0.09271692,0.035582725,-0.007886521,-0.039505634,0.07036238,0.0561824,0.015229812,-0.06797569,-0.010203853,0.04173073,0.1008168,-0.060998693,-0.027824009,0.000538392,0.06677297,0.00013997314,0.008055312,0.037186597,0.008588293,0.015887126,-0.0049428986,-0.053083863,-0.06473325,-0.0024266436,-0.07418966,0.011389913,0.09930053,-0.027113747,0.040012956,-0.017698623,-0.01283278,0.008589622,0.029213734,-0.0120906485,-2.412244e-08,0.004848304,0.0029534393,0.023252757,-0.05136708,-0.023893192,0.055629853,-0.014425339,-0.0072530257,0.10480956,-0.018301263,-0.07553205,0.0051145614,-0.008873774,-0.004894316,0.107373364,0.06669816,-0.010894328,0.0113935135,-0.038197014,-0.052875683,-0.043760486,-0.0057472116,-0.12219759,0.03493053,0.0032417958,-0.06287997,0.037392065,0.020097867,-0.05708826,-0.088306345,-0.023525441,0.048122536,0.018265555,-0.005582556,-0.04533511,-0.0058102245,0.009457764,-0.08359889,-0.0075297533,-0.03064397,-0.05799695,-0.05042587,-0.026609642,-0.025329707,-0.011497932,0.0615312,-0.0016835234,0.0030139931,0.037956096,-0.02261378,0.06716361,0.01218721,-0.013773176,-0.11102771,-0.07296082,0.0042819926,0.01959389,-0.105804354,0.01995638,-0.015953038,0.080031075,-0.06505599,0.097637765,-0.0025871592 +3.6.4.1,Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15-27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.,384,0.99999994,-0.06002851,-0.07493089,-0.021536151,-0.03418347,-0.09975699,-0.02007794,0.062334497,0.09978175,0.075017735,0.010171594,0.073386446,-0.015894176,-0.03738426,0.08683116,0.006612667,-0.00608855,-0.021572744,0.07367973,-0.023041867,-0.06516445,0.11706927,0.07789566,0.03631889,0.02771217,-0.028453836,-0.042289834,0.04484149,0.072188966,-0.006301215,-0.09902421,-0.07984659,-0.06823824,-0.045404844,0.023886269,0.0735979,0.11184483,-0.018900113,-0.08449039,0.02296072,-0.04180612,0.066986285,0.016039833,0.088343404,0.013794336,0.058576755,0.070920475,-0.029051898,0.01655164,-0.0023728553,0.06580505,0.01008969,-0.073634066,0.030055815,0.061462466,0.009993832,0.020022945,-0.11115889,0.02493808,0.0058560665,0.0024731632,0.055885244,0.03007327,-0.02579353,0.03084319,-0.0026850032,-0.044033647,0.0063726306,0.049241655,0.00223302,0.02153539,0.017651217,-0.05175093,0.0061860066,0.038144924,0.020391367,-0.08439623,-0.05018986,0.0030044424,0.028416552,-0.041514475,-0.002657931,-0.012037267,0.0079909945,0.06178378,0.019828614,-0.0003722536,0.058292948,0.069463186,-0.06900081,0.031520233,0.011405349,-0.012099715,-0.005217359,-0.03287639,-0.007365141,0.019212643,0.028353749,0.011865738,-0.03943226,0.0038551677,0.069267526,-0.0032827668,0.048791826,0.0058146846,0.010930022,0.025482617,-0.04857746,0.01175272,0.010449698,0.09263317,-0.013772548,0.0005246477,-0.015657226,-0.042859584,0.0389889,0.042499598,-0.014360727,0.047699653,0.008727665,0.021743573,-0.047909107,-0.08012728,-0.05804832,0.03298698,-0.07570006,0.03781027,-0.070149794,9.788393e-34,0.055133738,-0.15398115,0.0045596794,0.011924477,-0.073974654,-0.046721615,-0.004895826,-0.06928013,-0.04991515,-0.023590108,-0.061111648,-0.029579435,0.080690525,0.08385932,-0.042099815,-0.08482442,-0.014112353,-0.022654196,0.0960722,0.07003381,0.00073635776,0.11165757,0.0066074417,-0.037583746,-0.002945932,-0.019825757,-0.090844676,-0.025308287,-0.010083031,-0.008280298,-0.044491157,-0.06641634,-0.059241615,0.051902615,0.058967452,0.00032538906,-0.021861054,-0.056627154,0.037444025,-0.050618965,0.0051486823,-0.021980524,0.0014833636,-0.07469769,0.026676293,-0.015623678,0.03980388,-0.022256345,-0.041489277,0.020383056,0.08751309,-0.0039960584,0.09611728,-0.094582945,-0.04317218,-0.018094802,-0.031257465,0.05675936,-0.016701091,0.06695753,0.027716856,0.055510305,0.024259962,0.04812274,0.0049751974,0.0624449,-0.14860223,-0.01762936,0.041757092,-0.0066307,-0.031228747,-0.045516547,0.037084177,-0.0548653,0.065217994,0.029568497,-0.042254567,-0.008879584,-0.12469258,0.05465589,0.02016282,-0.022140045,-0.026032286,0.045040987,-0.004665246,-0.01594131,0.061853,-0.07704557,0.014490958,0.012431408,0.040783517,-0.03835299,-0.0714369,0.091013655,0.044469815,-3.0236356e-33,0.081580386,-0.019664,0.11325263,-0.032837387,-0.04531356,-0.0006615652,0.035870507,-0.012874377,-0.03977961,0.040602848,0.13505776,-0.027085582,-0.15676586,-0.010538584,0.037266523,0.035860512,-0.116163924,0.01935314,0.059184395,0.026146142,-0.06719109,0.08994074,0.04658405,0.08069717,-0.015248446,0.0023044264,-0.060245346,0.022979306,0.016917484,0.011342609,-0.04184907,-0.08839919,-0.07561358,-0.036833175,-0.049149524,-0.034467842,-0.02891011,0.023782253,0.04436205,-0.10250229,0.07042801,0.042487863,0.039037183,0.07392634,0.008577717,0.0378758,-0.012258021,-0.035137765,-0.15015836,-0.0038070208,-0.070890285,0.012756324,0.032850534,-0.012922227,0.0704646,0.03831834,0.03373208,0.03940478,0.053094126,-0.009673891,-0.059938736,-0.08412516,0.015041444,0.03841165,0.09717248,0.05001371,-0.06294798,-0.022696195,-0.014140442,0.0549873,0.011933521,0.030215211,0.03419281,0.01781408,0.049668085,-0.04114593,0.025974343,-0.08286324,0.0041791047,-0.03925121,-0.004779387,0.026421951,-0.058018185,-0.074871026,0.05306907,0.023610441,0.023750337,0.019848324,-0.032578107,0.031656757,0.10838353,0.038604863,-0.031233657,-0.019634446,-0.004510934,-3.3583927e-08,0.05479227,-0.025294513,0.0699767,-0.12413191,-0.013941285,0.014705797,0.06659896,0.05704478,0.06361672,0.044976953,0.08054137,-0.007371032,0.028499069,-0.03914922,-0.043675844,0.05248344,-0.074416436,0.0070525403,-0.028348047,-0.08890541,-0.020876188,-0.04151739,-0.020285882,0.047617495,0.02661597,-0.034271725,0.0007322881,0.05840716,0.015315977,-0.04051453,0.04816893,-0.021807339,-0.008749621,-0.05339939,-0.05914258,0.023337005,-0.0643971,-0.018647196,-0.08305654,0.033212382,-0.045097023,-0.073174775,0.009489945,0.010181854,0.026842251,0.0051453034,-0.009371096,0.008447483,0.022767337,0.054962818,-0.025693208,0.0050634164,-0.017686088,-0.01975454,-0.07820279,-0.02268494,-0.031153454,0.007531786,-0.013557136,0.007870408,-0.03232454,-0.0383922,0.04458434,-0.050655734 +3.6.4.2,"A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa).",384,1.0,-0.01795108,-0.052803766,-0.012793717,-0.06026345,0.025644997,-0.005956589,-0.02309768,0.027852383,0.027514393,0.014211798,0.030349296,-0.041971177,-0.032061912,0.03637216,-0.035310987,0.03771165,-0.09727838,0.083104335,-0.051561516,-0.08372315,0.04764958,0.0078092297,0.031239757,-0.013854109,-0.02319685,0.029401291,-0.044437196,0.023796957,0.00091779954,-0.072654046,-0.03618532,0.022721931,-0.06960076,-0.012865651,0.051435083,0.08729959,-0.049372688,-0.07071935,0.055405457,-0.041059762,0.10701562,0.0036506203,0.066027954,-0.006674296,-0.057540946,0.026663635,0.015766561,-0.028898735,0.06440062,-0.017754259,0.011231453,-0.09526343,-0.050236646,0.08390625,0.026140757,0.04617212,-0.08881328,-0.012186925,0.050966304,-0.03118715,0.04758255,0.022200322,0.021924336,0.023754979,0.1054282,-0.06414507,-0.025552358,0.0005462347,-0.013320469,0.012257281,0.014242592,-0.12866612,-0.05291629,0.05534049,-0.030591175,-0.031269718,-0.069611475,-0.0147074815,-0.023573456,0.04225907,-0.022149025,-0.002057461,0.04809066,0.00558231,0.05742287,-0.020891255,0.037490685,0.057055585,0.03267779,0.03053972,-0.026551625,-0.0076390826,0.0071401913,-0.0037201252,-0.04151398,0.0013765224,-0.012814772,-0.017751496,-0.007895051,-0.022492232,0.08216329,0.067407005,0.08311685,-0.010390709,0.032650173,-0.0051348056,-0.015068515,0.099432655,0.01672759,0.053481437,-0.0086794365,-0.022679301,-0.013087792,-0.025275843,-0.018758088,0.018908124,0.051660653,0.044588238,0.015713222,-0.015380332,-0.01674523,-0.08106615,-0.035049736,0.0024565589,-0.060623676,0.036190387,-0.14728059,9.532089e-34,-0.021674968,-0.14401825,0.055620763,0.0075993435,0.018703474,-0.04324963,-0.077300526,-0.052799974,-0.006581575,-0.030471923,-0.0783201,0.05988888,0.062005553,0.02860815,-0.09279967,-0.10003639,-0.0042442726,-0.02939887,0.0902008,0.037091706,0.051768955,0.083111435,0.007305188,-0.03337506,0.06490459,0.0011226154,-0.027009562,-0.01670322,0.023793682,0.015155651,-0.052840233,-0.10708853,-0.09709711,0.028897965,0.023356184,0.016768437,-0.03005325,-0.063790716,0.013239778,-0.0027931246,-0.094064415,-0.02083585,-0.038295086,-0.08935253,0.0052416245,0.04250517,0.04127311,0.00804551,-0.035390917,-0.0049232477,0.06799668,-0.07294514,0.019824743,-0.02589012,-0.031795423,0.045749612,-0.009389993,0.0675572,0.0019380627,0.06410266,-0.025543002,0.040209353,-0.041700676,0.055203084,0.08414012,0.08345325,-0.15050031,0.017597849,0.060921997,0.03307536,-0.10706356,0.04768542,0.10901301,-0.04165167,0.07416816,0.042574015,-0.046046488,-0.090586945,-0.112958156,0.10612888,0.01321523,-0.056789536,0.04624074,-0.019932851,-0.002202412,0.0023647828,0.025249468,-0.025460199,-0.046531603,0.0051889373,0.11238641,0.020545358,-0.005642037,0.07786214,-0.031774182,-3.3521436e-33,0.036234498,-0.059315726,0.043977126,-0.060997196,-0.025714947,0.013599175,0.01568988,-0.07793611,-0.038409926,0.04456857,0.029393258,-0.011919597,-0.11245844,-0.03858926,0.014115664,0.012142108,0.002067382,0.013432988,0.032661673,-0.005641435,-0.0772882,0.10954929,0.046924725,0.04914881,-0.04219398,0.02200116,0.023254693,-0.051486343,0.006779396,0.013798192,-0.044635974,-0.042281765,0.01998154,-0.0024455183,-0.038954623,-0.0036310018,-0.022706768,0.028776392,0.05698079,-0.011334801,0.06094023,0.04937291,-0.023897918,0.033280876,0.010837912,0.031127373,-0.052202217,0.04133291,-0.10279646,-0.040573873,-0.008230599,-0.023040505,-0.0075352183,0.011541714,0.06101473,0.0073694023,0.04514326,0.044432778,0.046625387,-0.044113055,-0.067503445,-0.11040655,0.03600783,0.027246702,0.041922066,0.065869085,-0.0734987,-0.0375269,-0.07154269,0.068987414,0.013672054,0.022185143,0.031058129,0.009462233,0.051459983,-0.016512416,0.03157362,-0.04235624,0.0021203335,-0.0065849884,-0.049908713,0.021236157,-0.04057727,-0.1009171,0.0554843,-0.0845697,-0.012485633,0.10728918,0.018067596,0.017270511,0.0844648,0.018049158,0.001982333,0.03242117,-0.001193064,-3.710559e-08,0.032220095,-0.046954557,0.019902745,-0.055102866,0.027301354,0.0690152,0.07778322,0.08854586,0.10271185,0.020790115,0.09365231,0.04581083,0.02575642,-0.0037179731,0.044209395,0.083343714,-0.020558983,-0.03172599,0.0041438476,-0.06535066,-0.06755876,-0.068552546,-0.07160839,0.11352485,-0.016060045,0.006851916,0.040422313,0.0441161,-0.07084463,-0.08423523,-0.024021946,0.038058724,-0.037242256,0.0009238602,-0.10462209,0.03338792,-0.0003066503,0.0010287496,-0.022259494,0.050651982,-0.031293947,-0.056812033,-0.04573037,-0.021019675,0.024494685,0.06281383,-0.022983106,0.07714524,-0.014057556,0.03940714,0.029567562,0.028215157,-0.010692408,-0.014738611,-0.072414145,0.011487903,-0.058704793,-0.03688473,-0.05944976,-0.04238096,0.045678448,-0.018129319,0.12766202,-0.028787274 +3.6.4.3,"Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.",384,1.0,-0.04797443,-0.039607603,-0.013482447,-0.10157121,-0.017221395,0.05791744,-0.04255683,0.041019473,0.0102210855,0.026877603,0.035862986,0.009863665,0.054796543,0.052156743,-0.031282816,-0.044393536,-0.09707015,0.06505599,-0.041293684,-0.084065855,0.038936067,0.025726466,0.05971471,0.015345815,0.03450481,0.011906929,-0.01649912,0.026105946,-0.00486904,-0.018731484,-0.10951319,0.021344736,-0.040661294,-0.042762857,0.12506972,-0.013322769,-0.047189884,0.0053475383,0.026554441,-0.053467143,0.19228885,-0.041347682,0.066955715,-0.002162896,-0.012961988,0.051821653,0.06841037,0.019788694,0.09741628,0.033460446,-0.032613494,-0.08686903,-0.0138124805,0.027546141,0.02668073,0.06640706,-0.03959199,0.059776336,0.08180588,0.024239492,0.0016315345,-0.029667107,0.045160647,0.011451221,0.06124604,-0.08522507,-0.012943524,0.026523115,-0.023454117,-0.0082341,0.0232647,-0.0656518,-0.061894987,0.01687241,-0.025265884,0.011334708,-0.061608296,0.0060860827,-0.062806025,0.094567634,-0.01761875,0.009575765,0.064849295,0.010510317,-0.0033429496,0.015748506,0.08260418,0.011632273,0.022179704,-0.027171453,-0.09745011,0.0065455292,-0.016358865,-0.062059116,-0.050833568,-0.047704652,-0.019195117,0.04547737,-0.032369077,-0.0077922954,0.11927256,0.010182096,0.060631588,-0.017368624,0.021130601,-0.015839672,-0.029493708,0.025658572,0.025475752,0.038701683,0.03425829,-0.028306078,0.06525721,0.01674551,-0.031620152,-0.022684956,0.072507285,0.009525094,0.03846187,-0.033506297,-0.025109805,-0.02573507,0.011155975,0.028020725,-0.07549764,0.06239414,-0.12110185,-7.624473e-34,-0.038733114,-0.055779275,0.037943777,-0.0023301002,-0.010767823,-0.0036408834,-0.0650025,-0.0012068616,0.013804924,-0.041260425,-0.1033246,-0.017314339,0.09404518,-0.038945206,-0.06297501,-0.05843332,-0.011200521,-0.026132703,0.034140687,-0.030604549,-0.017120445,0.10887978,0.027586257,-0.0012771067,0.009971145,-0.05464589,-0.065396644,-0.029156776,0.04478421,-0.032206245,0.003637498,-0.023557708,-0.120930225,-0.036150713,0.016045026,0.0078631835,-0.045848493,-0.0082498435,0.0076863156,-0.022807704,-0.108372815,0.0095900735,-0.043555245,-0.0279362,-0.0048577576,-0.002381058,-0.0329398,0.023211062,0.027637897,-0.011459448,0.056180917,-0.04059782,0.06298884,-0.014801866,-0.07677027,0.04245992,-0.043258574,0.020008601,-0.01607255,0.04746103,-0.01946032,0.03546718,-0.029371656,0.040904,-0.00091621256,0.07308825,-0.056491572,0.004710669,0.05683775,0.019873112,-0.051601693,0.038785238,0.07479382,-0.009622661,0.07215408,-0.021830862,-0.0025929075,-0.04970974,-0.06658941,-0.024545336,0.047932103,-0.026545951,0.038692486,0.0017567782,-0.038712204,-0.014713304,0.0115440935,0.03149757,-0.033307746,0.024266595,0.13155046,-0.0062968372,-0.0016552308,0.10103604,-0.04330702,-7.6964487e-34,0.024051001,-0.063499324,0.07127227,-0.061174646,-0.015023023,-0.03428033,0.05179039,-0.047573,-0.032936692,-0.022845458,-0.002815064,0.051165387,-0.065389134,-0.041096237,-0.019071363,-0.01757202,-0.021800922,-0.0068187867,0.074361734,0.014938305,0.020923233,0.0318306,-0.010601708,0.061972145,-0.064421594,0.015427591,0.02757028,-0.030872127,0.09115005,0.04166406,-0.062404335,0.057038434,-0.0044912025,0.008495493,-0.066394486,-0.041496564,0.019625971,-0.021441171,-0.031287793,-0.016767824,0.041178618,0.049545497,-0.07578311,0.10368016,0.057278834,0.06532312,0.041772,0.082120925,-0.17223202,-0.00049067737,-0.039470866,-0.006994472,-0.005211774,-0.0054313447,0.029114135,0.028155308,0.070602775,0.03572485,0.0042435154,-0.0015297252,-0.003782167,-0.0957901,-0.030324103,0.016683474,0.018416895,0.087657765,-0.0010197625,0.039289653,-0.07446997,0.10597203,0.05287737,0.07289388,0.012604591,-0.03275247,0.050642233,0.042520072,0.010038228,-0.014068818,0.015929954,-0.017946044,-0.06311343,0.087626494,-0.04255034,-0.058196325,0.062808655,-0.026909282,0.014362151,0.10875626,-0.0042301957,0.041968808,0.06725668,-0.05078121,-0.03123081,0.081570275,0.011838977,-2.1239101e-08,0.06760664,0.020140432,-0.000535236,-0.020088984,-0.018062554,-0.016528687,0.014169958,0.12236009,0.092620894,0.0046873945,-0.00955866,0.01333975,-0.009828293,-0.025978487,0.07618,0.0863991,0.0049234005,0.008115699,-0.04997183,-0.028591879,-0.093631566,-0.012380996,-0.08492117,0.044871572,-0.04388192,-0.061524924,-0.029810652,0.13440883,-0.12394227,-0.096818484,-0.0053113336,0.008937393,-0.051044792,-0.050703097,-0.09459734,0.00284423,-0.01311575,0.004195727,0.052941024,-0.07751991,-0.06787792,-0.10500016,0.040123686,-0.046428464,-0.0009516228,0.049697783,0.07261445,0.023422165,0.01783194,0.0060500293,0.009765144,0.037297405,0.04219451,-0.079070695,-0.09295041,-0.027825834,-0.021394521,-0.021061245,-0.056161962,-0.044606443,-0.005367382,-0.012905811,0.12328597,-0.0750827 +3.6.4.4,"Microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (alpha) chains (110 kDa) and two or more light (beta) chains (65-75 kDa). Also hydrolyses GTP.",384,1.0,-0.07913476,-0.14713708,-0.008472018,-0.0985089,-0.024410462,0.0368263,0.03694233,0.023376957,0.03702775,0.06217682,0.037778325,0.03547162,-0.06071586,0.01693876,-0.043557372,0.060381856,-0.06436654,0.051603198,-0.09293419,-0.033331934,0.053438757,0.024771336,-0.014845088,0.016408378,-0.016668538,-0.015019109,-0.0066335164,0.05833942,0.039129008,-0.06480435,-0.05644649,0.052986037,-0.10174692,-0.005578709,0.025178285,0.010256713,0.022121286,-0.10071193,-0.03057655,-0.082763,0.13059038,0.024020854,0.045512687,0.009842024,0.00503046,0.09018444,-0.008755425,0.025382178,0.041276168,-0.016828366,-0.048175715,-0.116059646,-0.0012031831,0.047417454,0.013211576,0.026350476,-0.05420358,0.03848374,0.07830432,0.0026960203,0.0473413,0.010338564,0.059245355,-0.0073452997,0.03944545,-0.05610735,-0.043650873,-0.015610746,0.01260474,-0.0074884947,0.06681371,-0.093062416,-0.09239016,0.08082293,-0.043432884,-0.027773842,-0.019869408,-0.016971294,0.029760405,0.03339472,-0.05710392,0.007459713,0.073657,0.0885859,0.024296762,0.041772928,0.041027043,0.028122406,-0.0069806497,-0.02027306,-0.03426179,-0.012878834,-0.027042717,-0.045287848,-0.00948164,-0.015850646,0.018558206,-0.04012103,0.02031137,-0.00041599871,0.026247606,0.06357388,0.025125535,0.009736781,-0.07375187,-0.02951845,0.013127467,0.012421742,-0.0074715195,0.0102172615,0.038065933,-0.034931663,0.030341938,0.08301956,-0.027091963,-0.07041444,0.009138212,0.040530406,0.07447738,0.0024735378,-0.01698461,-0.06577481,-0.04608096,0.044438235,-0.071684375,0.02005475,-0.14791304,1.0026239e-34,0.031709094,-0.10329654,0.06759919,0.01656912,0.005148896,-0.051521245,-0.039668724,-0.048265867,0.049440026,-0.03265931,-0.077833906,0.011324642,0.024781665,0.03701943,-0.063841805,-0.14422607,0.019007668,-0.044787597,0.052941673,0.052170806,0.061527334,0.12727602,-0.029646073,-0.045334928,0.08690989,-0.009261065,-0.07090904,-0.0056936024,0.06537572,0.0030918887,-0.05976497,-0.11860782,-0.12393571,0.07955588,-0.026712501,0.04093259,-0.03978369,-0.12243102,0.015266321,0.032497376,-0.040841233,-0.072181396,-0.08446595,-0.070027664,-0.024408955,0.046718497,0.028471144,-0.052351024,-0.007834355,-0.059128743,0.049940534,-0.022787573,0.02588114,-0.1112138,-0.009945119,0.039210487,-0.06526693,0.021702193,-0.019374337,0.056046642,-0.014064528,-0.01732621,-0.02411018,0.080104806,0.08523233,0.03319915,-0.09713451,0.04212938,0.019631429,-0.02649483,-0.04993033,0.021780448,0.1135758,-0.042250354,0.066586,0.020598901,-0.047525976,-0.046745475,-0.04392387,0.03092125,-0.00010727339,-0.051170386,-0.07826067,-0.004842666,-0.006048706,0.045834158,0.063606724,-0.0017434007,-0.041097756,0.0065776203,0.078630276,-0.050177377,-0.02785863,0.08236888,-0.028976936,-2.8974189e-33,-0.07114095,-0.0615868,0.06579906,-0.0020180258,-0.01183537,0.06493169,0.072035454,-0.046377648,0.0124014625,-0.016250966,0.063827604,-0.0029655683,-0.10274914,-0.008083501,-0.002793151,-0.0067392476,-0.014635171,-0.008408458,0.04255464,-0.012629332,-0.0341467,0.07846494,0.055041686,0.086841166,-0.023330458,-0.027992949,0.018966787,0.015959304,0.0013281457,0.05035115,6.553886e-05,-0.005055972,0.016602851,0.009247289,-0.028111547,-0.028109243,-0.03862602,-0.0058837812,0.07055377,-0.061535053,0.0026219063,0.005843868,0.015154711,0.060937345,0.051088676,0.08324071,-0.020441554,0.022151455,-0.061622094,0.02126097,0.0007966974,0.024122585,0.013958505,-0.010859344,-0.0067911255,0.014844568,0.09906355,0.075235195,0.0664882,0.061827388,-0.03713549,-0.05797274,-0.018166363,0.062561505,0.015076493,0.0799182,-0.053419497,-0.039577946,-0.018530324,0.03586876,0.061751686,0.04470453,0.07548306,0.046854142,-0.011020441,-0.082782336,0.029384593,-0.023310564,0.058974367,-0.02912171,-0.043070942,0.088427074,-0.0593719,0.0030494705,0.0031252734,-0.020264482,-0.021707527,0.10046385,0.011977853,0.026149977,0.0515665,-0.0092268875,-0.034508783,0.011684646,-0.0023044376,-3.4159704e-08,0.08149723,-0.008156568,0.053731374,-0.11332867,0.0116140125,-0.010841695,0.08309949,0.097208925,0.06834549,-0.005849246,0.06143789,0.021933254,-0.0023489674,-0.03947515,0.024200022,0.07960626,0.021820573,-0.037590828,0.026282238,-0.042114895,0.04346136,-0.038678803,-0.044262975,0.052393112,-0.08526691,-0.02444399,-0.020179825,0.0698698,-0.037415437,-0.07990441,0.0016470924,0.035259027,-0.019720197,0.002362089,-0.16153406,0.044295378,-0.008059777,-0.028410835,0.024342466,0.01078823,-0.029798992,-0.026044114,0.019524194,-0.05559309,-0.028529879,0.015029731,0.016602498,-0.0178555,0.009845839,0.026064727,-0.0059196944,0.023993324,0.025665523,0.009222089,-0.0937874,0.019971972,-0.04683735,-0.017870665,-0.06091724,0.0148915015,-0.034054954,0.003391643,0.09423015,-0.035108708 +3.6.4.5,Structurally almost identical to EC 3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules.,384,1.0,-0.06502354,-0.052318424,-0.008479237,-0.0629534,0.011288857,-0.005200389,-0.05028592,0.045156967,0.042378157,-0.0013418521,0.05414811,-0.0093530845,-0.02029523,0.010846528,-0.036340073,-0.03804734,-0.091303006,0.050744444,-0.035660397,0.023339732,0.00095217035,0.033507846,0.027716475,-0.016945982,0.035906695,0.052762613,0.0030999414,0.0068953442,-0.002177375,-0.06476351,-0.0711958,-0.01927893,-0.03148145,-0.08392309,0.08665233,0.03461876,-0.06740381,-0.07461183,0.01045638,0.015501586,0.1443501,-0.04666718,0.002373971,-0.016682968,-0.025020972,0.0010513766,0.002826683,-0.012629775,0.031043377,-0.03877607,-0.04204089,-0.11947934,-0.060831305,0.0069417413,0.0020477897,0.03810595,-0.073688745,0.061948378,0.026254052,0.041315157,0.06809231,0.024752067,0.03555499,0.05122728,0.10600867,-0.042439908,0.011652929,-0.099420495,0.023262318,0.0093113715,-0.058660172,-0.1052402,-0.062200848,0.06414432,0.0071567316,0.026914688,-0.03700194,0.043418076,-0.024431475,0.03827408,-0.011001399,-0.05231882,-0.011303119,-0.030247632,-0.0114544295,0.03507152,0.076120526,-0.01502443,0.0665717,-0.011118993,-0.00984319,0.00556606,-0.007577674,-0.03483553,-0.036511485,-0.001930822,-0.01182775,0.121321835,0.056031574,-0.0040274826,0.068101265,0.11087554,-0.04965993,-0.004686924,0.054911084,-0.00044047603,-0.037230756,0.07468332,0.024858903,0.009465806,-0.010279395,-0.0899015,0.0191783,0.007985069,-0.009700787,0.030765506,0.025213752,0.029132245,0.06507076,0.044557218,0.03781579,-0.062430006,-0.031337727,0.0006943483,-0.06750978,0.061633304,-0.13225602,3.5215203e-34,-0.006595329,-0.055880025,0.11286927,-0.06530194,0.020126231,0.0046258112,-0.08837721,-0.007879955,-0.04166505,-0.035251312,-0.106003076,0.027561832,0.044271685,0.004875363,-0.06292128,-0.10323629,-0.042719346,-0.0029800718,0.04033664,-0.013172455,0.088272005,0.02506275,-0.015082006,-0.013116512,0.038840998,-0.035547346,-0.05587032,-0.039255626,0.025671002,-0.016385796,-0.03759168,-0.08812213,-0.05850765,-0.00645338,-0.038887613,-0.011492345,-0.03345878,-0.06858397,0.025065852,-0.008723088,-0.059356872,0.021644274,-0.019397583,-0.06337244,0.02906963,0.0020266748,-7.9428886e-05,0.03183261,0.04476849,-0.024064902,0.046968326,-0.054365676,0.11194551,-0.06307322,0.036957264,-0.011964361,-0.048090883,0.080375314,-0.005290782,0.065381065,0.019735664,0.089946106,-0.028624319,0.036461927,-0.0077150124,0.09928349,-0.098966606,0.042483293,0.05709857,0.033222403,-0.08301658,0.063675545,0.052204292,0.003287808,0.09152472,-0.026306445,-0.08007592,-0.0778664,-0.036349323,0.0056638033,-0.03118533,0.0023719026,0.0034075566,-0.009776544,-0.074712425,-0.008226495,-0.001015602,-0.004913555,0.042017106,0.07707807,0.09944296,0.00020927803,-0.079608165,0.10799427,-0.042567655,-1.8724697e-33,0.028404048,-0.08279026,0.021718357,-0.03016193,-0.0599751,0.021433404,0.044835396,-0.0030886119,0.008464877,-0.013558397,0.054670364,0.01529553,0.0020235109,-0.06818252,-0.00273984,-0.01345666,-0.037344627,-0.052139986,0.059115622,0.013887259,0.027967175,0.031528704,-0.022499995,0.06990077,-0.002387053,0.003972629,0.032771707,-0.0070116953,0.041000184,-0.0067856573,-0.056822594,-0.0038037456,-0.003221784,0.003687296,-0.06374334,-0.003300949,0.0004886471,-0.0006297609,0.08284947,-0.052980684,0.042089224,0.06803645,-0.017526558,0.09106035,0.08382255,0.08445063,0.034267534,0.057683665,-0.089674175,-0.047264613,-0.044647038,-0.011641129,-0.02751357,0.025067642,0.018465474,0.032349005,0.066009395,0.021683455,-0.0073323925,0.0027163164,-0.026884116,-0.08225155,0.04187117,-0.027354244,0.061792005,0.09145791,-0.03127771,0.044412144,-0.046612054,0.012540254,0.095313706,-0.006258953,-0.05793575,-0.038035776,0.05789504,-0.025843114,0.041949335,0.0030498486,0.012440663,-0.04045426,-0.02686347,0.094652094,-0.04621966,-0.055112746,0.013625686,-0.017871756,0.011502681,0.09599627,-0.028250147,0.07011043,0.016363043,-0.027268646,-0.040540706,0.061167467,0.05191103,-2.9277611e-08,0.09826523,-0.0066001574,0.058641817,-0.023252899,0.062056895,0.06466345,0.041871954,0.06673083,0.088052854,-0.009857073,0.024569148,-0.00081128365,0.039244216,-0.035657715,0.08306676,0.056003813,-0.04520381,-0.006210175,-0.017649662,-0.025971081,-0.049693026,-0.025190415,-0.11220251,0.036511544,0.0037911634,-0.049669746,-0.04680862,0.0840932,-0.11400436,-0.08047682,-0.015384981,0.03022406,0.03892321,0.01022338,-0.10122211,-0.0026420648,-0.030746069,-0.02095304,-0.05049621,-0.00060188555,-0.053696558,-0.14867716,0.0024110004,-0.035262447,-0.014360991,0.08448731,0.037532844,0.019138925,-0.01155094,-0.008109449,0.0612699,-0.05871685,0.048207767,-0.068051204,-0.0672982,0.0006729045,-0.0669596,-0.04264689,-0.040200084,-0.023927452,0.02811884,-0.022823766,0.18202765,0.0019572894 +3.6.4.6,"A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (_A_TPase _a_ssociated with a variety of cell _a_ctivities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.",384,1.0,-0.105411425,0.0053088237,-0.0026441352,-0.023172686,-0.028831907,-0.046208944,0.03205883,0.062802985,0.06281874,-0.030501476,0.06423783,-0.08214992,-0.021675881,0.06673581,-0.06045702,0.008216133,-0.09179541,0.030469203,-0.042441867,-0.084608145,-0.009055717,0.059651498,0.028447118,-0.015694832,0.025992615,0.027705716,-0.03998332,0.032395735,-0.0009426291,0.005587171,-0.10730041,-0.05757387,-0.05306927,0.004452339,0.07627288,0.063679114,-0.09003984,0.024667611,-0.011678184,-0.06713254,0.10669911,-0.026310224,-0.010414428,-0.025992611,-0.121605754,-0.005773538,0.040123742,0.021495914,-0.029323414,0.016494684,-0.019395448,-0.1348814,-0.03142297,0.009739703,0.055339918,0.012050029,-0.088515386,-0.03163303,0.003740551,0.06280442,-0.003662307,0.013055823,0.020823296,0.0295277,0.048846893,-0.06332643,0.03348306,0.033610627,-0.018963143,-0.08924917,0.0062345047,-0.048466288,0.014347926,0.013813473,0.0012301238,0.052109733,-0.021885023,-0.016631052,0.018916195,-0.06270093,0.041963864,-0.0075520347,0.042107742,0.04798336,0.08513273,-0.080146596,-0.017099408,-0.005027475,0.014920616,-0.011926854,-0.05870464,-0.05716167,-0.0036993197,0.0073072603,-0.016627586,0.0070973244,-0.0034912408,-0.06285928,-0.042090822,-0.009008365,0.02145082,0.032844488,0.11289946,-0.0030298962,0.062113687,0.014334938,-0.040635187,0.07366473,-0.00015011469,-0.010566572,-0.039308198,-0.019574512,0.08785781,-0.012766801,0.023369852,0.035612237,-0.010360148,0.0331083,0.0816019,0.057595417,-0.04850344,-0.03622962,-0.018951017,0.02309491,0.03190599,0.05858776,-0.10067523,1.0391316e-33,0.011344511,0.05315368,-0.06580015,0.09924515,0.02519554,-0.0017677797,-0.040917825,0.023734828,-0.04893878,0.00773457,-0.04545407,-0.073444754,0.020685084,0.018525211,-0.017974043,-0.0441699,-0.07894581,0.038888387,0.023936244,-0.07488921,-0.02229369,0.1403194,-0.033473026,-0.056207824,0.051689707,0.04360321,-0.053992536,-0.059594795,0.050832253,0.018799042,0.06633144,-0.058588177,-0.11853665,-0.026904218,0.03235292,0.04133774,-0.05647013,-0.021674464,0.015526973,0.016384404,-0.12503242,-0.0018232373,-0.06089079,-0.08548402,0.045372114,-0.04766752,-0.05460001,0.09021103,0.04173274,-0.008144833,0.031195115,-0.059821323,0.007303687,-0.05824096,-0.0844357,-0.023184033,-0.0037066229,0.089659214,0.008080189,0.06729958,0.08009586,0.06674355,-0.12652026,0.043394372,0.087106936,0.011436016,-0.06732971,-0.12323515,-0.014833999,0.088334724,-0.024292706,-0.01017651,0.0747463,-0.030334251,0.0062758126,-0.04618999,0.05944233,0.021592826,-0.06138632,0.009273971,-0.03589757,-0.011430287,0.07020907,-0.04488031,-0.07893229,0.0038385934,-0.040771317,-0.035365183,-0.020004893,-0.007936364,0.1126575,-0.011283623,-0.10486906,0.022329422,-0.06754248,-3.1605616e-33,-0.026575157,-0.021860013,0.059791073,-0.14778371,0.009905354,0.030392637,-0.014880401,0.031917818,-0.016433535,-0.05264996,0.03542879,0.034675397,0.0019488297,-0.0662127,-0.077403575,-0.02461334,-0.043716073,0.043578967,0.09912375,0.030998673,-0.012080945,0.08657844,0.050110765,0.09484826,0.0029042694,-0.022262493,0.05336438,0.017433792,0.03209547,0.019175742,-0.03228926,0.00571963,0.023074217,0.021422634,-0.07034667,0.005807394,-0.021325994,0.021856776,-0.018175371,0.005658167,0.059991088,-0.0030653207,0.031139841,0.015737044,0.013780922,0.10269264,-0.044856742,0.019110465,-0.0247798,-0.0482958,-0.03184017,-0.008368561,-0.030120006,0.026452566,0.018234035,0.046177283,0.05620613,-0.041542016,-0.0376022,-0.0671173,-0.02154651,-0.0113556795,0.05258046,0.037459888,0.042582296,0.026842043,-0.051186748,-0.039348584,-0.027907861,0.03622216,0.09683862,0.021683978,-0.09774651,-0.07031865,0.028947758,0.026727084,-0.0012986518,-0.013133166,-0.018589376,-0.085644096,-0.020601785,0.083058886,0.017321566,0.016030721,0.043008067,-0.010355695,0.044412702,0.1311632,0.046309005,0.011224047,0.060882453,-0.0069980393,-0.064439856,0.05245614,0.036193565,-3.9415795e-08,0.076278724,-0.017457018,-0.02291028,-0.06497717,-0.01552242,0.0029246963,0.035593472,0.07315061,0.030515172,0.07816334,-0.046642862,0.12320889,0.0131590655,-0.0292467,0.039385423,0.03760912,-0.08396417,0.029725727,-0.02624479,-0.05581656,-0.018077468,-0.003090717,0.02711442,0.041943237,0.01674318,-0.02461517,0.017643485,0.03526457,-0.01494198,-0.042216644,0.01295896,0.05631284,-0.0022934503,-0.06373027,-0.031687073,0.03373995,-0.024968121,-0.008674527,-0.109044604,0.0059574866,-0.0226207,-0.058471773,0.034818266,-0.002160888,0.029146515,0.033083387,0.0010460184,-0.018261889,0.056964353,0.023885883,0.017644346,0.031208374,0.023112677,-0.040953007,-0.109857716,-0.039148718,-0.04736288,-0.017799567,-0.014271574,-0.013428025,0.10655035,0.04164524,0.15703082,-0.009704131 +3.6.4.7,An extremely diversified group of enzymes that use the energy of ATP hydrolysis to import and assemble peroxisome components into the organelle. Their molecular masses range from 25 to 600 kDa.,384,1.0,-0.030145848,-0.027355751,-0.02723658,-0.025958227,-0.05847939,-0.019860584,-0.052570786,0.0070826956,0.016343229,-0.019711085,0.03753096,-0.06049692,-0.075947836,-0.0072401976,-0.038489614,0.052185424,-0.048237402,0.052683305,-0.014687878,-0.0004209537,0.046073813,0.038783696,-0.0035360241,-0.038338494,0.02222522,0.038117718,0.029744137,0.006524229,0.034501053,-0.07726603,-0.025721261,-0.033376973,0.09305313,-0.018023813,0.057182435,0.1251043,-0.09614107,-0.012501384,-0.037746243,-0.036282443,0.056853395,0.017046554,-0.016237056,-0.01611335,-0.075808465,-0.07821926,0.06476095,-0.0086604655,0.024355628,-0.05005154,0.006706517,-0.10421042,-0.118636794,0.016609563,-0.020358087,0.018661212,-0.05798319,-0.062429033,-0.028785296,-0.03764894,0.045590878,-0.0032486168,-0.007578226,0.017541634,0.029951977,-0.057840396,0.07697305,-0.003626084,0.005582804,-0.09524394,-0.013318323,-0.056153666,-0.03088215,0.049881678,-0.043594666,0.023840569,-0.06361467,-0.032117773,0.06314001,0.0048380527,-0.0133768255,0.008576144,0.0064969487,0.03860879,0.08487555,-0.0290285,0.033252195,0.07031836,0.011433847,0.0047774343,-0.024937756,-0.020632107,-0.02461234,0.014590126,-0.010795751,0.08911782,0.053253796,0.004000561,0.05895325,-0.025309093,0.1028049,0.11646955,0.011408633,-0.06591656,-0.021459153,0.029475763,-0.053650778,0.054740686,0.07284204,0.050366722,-0.050932616,0.050107,0.039901,-0.0465296,0.033557985,0.022799281,0.008829283,-0.005650136,0.048732683,0.028196156,-0.07759408,-0.018376144,-0.0011826617,0.05762991,-0.011974228,0.046113614,-0.10285006,-3.7720064e-34,0.002625294,0.018031018,0.010531774,0.077628046,-0.045568947,-0.05550009,-0.07849108,-0.027288876,-0.034738787,-0.009714575,-0.093658075,0.029967096,0.03071184,0.017609408,-0.021180928,-0.11932387,-0.0056771357,0.048122704,0.07562739,0.006695032,-0.023542168,0.06089022,-0.031162392,0.0011456712,0.020705814,0.0883854,-0.0113829365,0.00022108636,0.018419582,-0.00068378274,0.008861361,-0.08865492,-0.09950036,-0.012119252,0.00389157,0.022776598,-0.06151503,-0.0415723,-0.008280336,0.026136395,-0.068792164,0.011380424,0.006212241,-0.09944043,0.07355472,-0.020653052,0.014941151,0.091741405,-0.013419465,0.009915837,0.0016432486,-0.002274598,0.06527027,-0.027269814,-0.07067908,0.020313947,0.016205838,0.059953317,0.05498445,0.08594294,0.031723306,0.13352115,-0.047597386,0.07537672,0.06577811,0.05624642,-0.10693021,0.03335871,0.0010466091,0.1170181,-0.061597906,0.01587311,0.0772333,-0.041563593,0.03311477,-0.0016834267,0.027745388,-0.02438765,-0.02212904,0.04562536,-0.034293693,-0.0025451453,0.029888472,-0.12197218,-0.032587804,-0.02786715,-0.0042011533,-0.042597525,-0.038662866,0.051403556,0.11467189,-0.03580729,-0.042114392,0.050210256,-0.05362997,-1.8942754e-33,0.08749348,-0.09226694,0.030178271,-0.11640762,0.030428527,0.045148186,-0.012264505,0.04369713,-0.036367536,-0.020469539,-0.026956916,-0.0019270543,0.036046304,-0.10371129,0.00062714936,0.00962307,-0.0067855804,0.0593816,0.021811463,0.02600703,-0.05290738,0.114104144,0.027344534,0.10506911,0.008623369,-0.018250972,0.04042517,-0.0068024155,0.040927976,-0.002850526,-0.008965108,-0.024852592,-0.0011772037,0.030992953,-0.062097836,0.033333305,-0.02298202,0.080764376,0.06413251,0.025215251,0.059543584,0.09560435,-0.08158612,0.030149752,-0.009346062,0.04625618,-0.10148542,-0.037262477,-0.047892835,-0.09733307,0.022938913,0.026638217,0.00633041,-0.055061862,0.030336948,0.020635374,-0.00808636,0.00028848642,0.07139231,-0.05446869,-0.0771216,-0.09141932,0.059678383,0.04435836,-0.052459672,0.05080355,-0.05931158,-0.02456362,-0.12337024,0.05907427,0.03787541,-0.0149974665,-0.042912368,0.0025928183,0.030622596,-0.008697115,0.038930334,-0.07503638,-0.0145418355,-0.03457584,0.005278184,0.016575122,-0.018947423,-0.05702647,0.03922299,-0.06042495,0.032805666,0.103821985,-0.004549008,0.00840172,0.02269076,-0.009708212,-0.036755413,0.019657021,0.08143972,-2.7274409e-08,0.020098958,-0.026036935,0.09345997,0.0004875165,0.027921274,0.037297066,-0.008835152,0.07108612,0.07299355,0.026760504,0.07227686,0.07182735,-0.009565421,0.006072862,0.03580179,0.067021415,-0.061977506,-0.003098942,0.006289287,-0.048196673,-0.03219911,0.030767005,-0.036627665,0.0515209,0.05126063,-0.042062048,-0.0085971,0.033865944,-0.055267043,-0.04631464,-0.026710793,0.020970568,-0.05297899,-0.022721287,-0.08586438,0.029840263,0.008485224,-0.02315841,-0.061664913,0.013545398,0.02229817,-0.1320257,-0.009673341,-0.022123812,-0.010564105,0.051553663,-0.07730179,0.056517337,0.008529266,0.034682203,0.052854415,-0.010087755,-0.027204359,-0.08671542,-0.0629126,0.004818562,-0.06329837,-0.04845624,-0.05087682,-0.076394394,0.070086345,0.0031503604,0.14783023,-0.08064094 +3.6.4.8,"Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.",384,0.9999999,-0.039911292,-0.091266885,-0.0040560765,-0.046059728,0.061684776,0.076916546,0.0062114727,0.032575574,0.0622969,0.060129333,0.07657496,0.03293844,-0.028036786,0.050301764,0.032111514,-0.07072875,-0.13045017,0.010439276,-0.058568086,-0.10308449,0.08386669,0.038150594,0.02702464,0.0040522562,-0.0019735494,-0.039888095,0.07102514,0.0011484276,0.01718778,-0.044470366,-0.036447022,-0.010193319,-0.039589297,-0.0039393464,0.103153095,0.058404993,-0.090804726,-0.026805956,-0.008388737,-0.022449974,0.11831486,-0.050271712,0.015278279,-0.035919547,-0.027459683,0.055838462,0.012770437,0.030404387,0.036176488,0.07154035,0.034943495,-0.107947014,-0.0011446171,0.030883322,0.04842509,0.027605608,-0.08810389,-0.021778794,0.033391364,-0.014674263,0.035279065,-0.005813241,-0.009715547,-0.01414072,0.004196378,-0.050420646,0.017136225,0.04460814,-0.0044207852,0.0038495483,-0.03982539,-0.04988517,-0.0037221797,0.06578007,0.034599427,0.04746438,-0.023469256,-0.07501326,-0.046213094,-0.056717027,0.013979895,-0.0229076,0.06599919,0.033939593,0.023124207,-0.007058261,0.074701525,-0.04595956,-0.007413705,0.03029469,-0.07742623,-0.07070554,0.014428294,-0.03772844,-0.07736449,0.0023094404,-0.06912697,-0.00035756643,-0.023996966,-0.0023582547,0.026195755,0.046356846,0.08056005,-0.045133065,-0.020558875,0.017637812,-0.04473764,0.12257873,0.0018557535,0.05582051,0.0047146003,-0.039647806,0.065901384,-0.01823636,0.06480002,0.11201531,-0.052748058,0.013582379,0.024150578,-0.007580706,-0.006070749,0.0013851181,0.02931052,0.07218737,-0.07416526,0.04483963,-0.09236058,1.2503027e-33,0.024564983,-0.024378832,-0.033123154,-0.008218305,-0.029700851,0.04332815,-0.049099006,0.007310048,-0.023278987,-0.007858653,-0.10560569,-0.066227555,0.09291983,-0.03476944,-0.05435382,-0.048488814,-0.064340256,-0.00035381963,-0.007615806,-0.008890249,-0.0014587461,0.06096395,-0.018300803,-0.025290258,-0.004756185,0.004474515,-0.04236739,-0.023048038,0.026431946,-0.0026106245,-0.0058731884,-0.025062537,-0.058204044,0.093355946,0.0132969245,-0.05968749,0.007857378,-0.057154678,0.03220379,-0.012936123,-0.009701324,0.003982565,-0.0358569,-0.05870013,0.055421278,-0.06591525,0.023530807,0.045283902,0.013358225,0.040434726,0.058351863,-0.014049308,0.08440474,-0.0053880964,-0.0717964,-0.025760215,-0.083646916,0.07516158,-0.005598081,0.030770818,0.052962415,0.08038564,-0.04163142,0.012094609,0.022112876,0.07923023,-0.045499425,-0.040079203,0.017918516,0.014041796,-0.072179064,0.051760036,0.089028455,-0.002475659,0.017824186,-0.007996408,-0.09368775,0.021123057,-0.047821574,0.07418807,-0.06470588,0.04411389,-0.052880455,0.07998506,-0.03004393,-0.035655614,-0.025312698,-0.07594753,-0.021883214,0.004726243,0.10980269,-0.03699124,-0.054578558,0.15061285,-0.024983933,-2.4190318e-33,0.015658509,-0.02995063,0.0912964,-0.06562141,-0.008910461,-0.02515348,0.09325458,-0.027556602,-0.039642867,-0.093112424,0.061741307,-0.009105373,-0.042194985,-0.028353617,0.037253942,-0.04437562,-0.13747016,0.025812373,0.09087312,0.056641683,0.024013037,0.00057400233,0.02844815,0.046039276,0.01601436,0.05532321,0.060295686,0.02966169,0.098177806,0.05109751,-0.040839437,0.087865554,-0.022178972,-0.01021083,-0.0923587,0.029655267,-0.031133775,0.0059010354,-0.011612469,-0.0804557,0.046702754,0.08665358,-0.011566557,0.012450848,0.039890405,0.098023854,0.06119716,0.050086148,-0.05410718,-0.036705803,-0.068996586,0.006219538,-0.018726725,-0.005865545,-0.013362774,0.050256513,0.057713162,0.04825284,0.027003717,0.021451484,-0.018887917,-0.023665616,0.021569686,0.033653624,0.019880032,0.035664503,0.028531576,0.05834752,0.00070096186,0.07035018,0.036544364,-0.015139043,-0.091306455,-0.05394952,0.016523886,-0.018492388,-0.019948985,-0.025407344,-0.011323715,-0.06895454,-0.082295395,0.09682081,-0.097309366,0.00134796,0.05671122,-0.007844799,0.0032580644,0.07011724,0.0060990495,0.052663352,0.021113351,-0.061688647,0.0032204099,0.07470022,0.008922343,-3.6789412e-08,0.0706418,-0.019753097,0.033316318,-0.07469346,0.047982194,0.0011702705,0.00012706128,0.08150928,0.0020166766,-0.00518379,0.026151352,-0.0018448178,0.000917822,-0.020541308,0.07542353,0.022243408,-0.07395036,0.08354038,-0.05119476,-0.045897126,-0.0010089778,-0.067636766,-0.08559645,0.09059383,-0.02989023,-0.05643576,0.027038462,0.0835506,-0.07993599,-0.09985942,-0.017095126,0.042617604,-0.01800834,-0.049046654,-0.02502741,0.07144475,-0.030270724,0.011987953,-0.051694997,0.0084426105,-0.05468066,-0.069934234,-0.0015979005,-0.020290118,0.04579521,0.041975155,0.048889372,-0.050354786,-0.012899296,-0.018867115,-0.08984722,0.0075025456,0.015441628,-0.05741139,-0.074705,0.00063731166,-0.08152315,-0.09617905,-0.031069318,-0.026356196,0.02835929,-0.00057807355,0.09343327,-0.106795095 +3.6.4.9,"Multisubunit proteins with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or entry into mitochondria and chloroplasts. Molecular masses of subunits ranges from 10-90 kDa. They are a subclass of molecular chaperones that are related to EC 3.6.4.8 (proteasome ATPase).",384,1.0,-0.008130099,-0.09634912,0.02314794,-0.031259395,0.020775588,-0.011939293,0.010981279,0.065913305,0.038471665,-0.0045404793,0.029851038,-0.08488102,-0.066893496,0.04814013,-0.014137011,0.011313346,-0.09048156,0.022625124,0.015310796,-0.061040144,0.13326035,0.012222417,0.0031016457,-0.00029422808,-0.052385096,0.011765286,0.0051487507,0.02632217,0.0037888074,-0.062359743,-0.03780486,-0.005414727,0.0052705393,0.021499502,0.066061825,0.044274222,-0.095336705,-0.041687597,0.009281521,0.0120982975,0.14203982,0.047207173,0.03967385,0.013443495,-0.013912946,-0.013727722,-0.019107725,0.02633916,0.09468202,0.0077739856,0.08680485,-0.07724797,-0.054084755,0.12463555,0.042791896,-0.0073314356,-0.11936668,-0.007497228,0.057301693,-0.032022458,0.043150924,0.010500063,0.03872712,0.009126609,0.09040943,-0.008722286,-0.012552165,-0.034357384,-0.03648862,0.00754467,0.01526219,-0.011856502,-0.034273434,0.13219479,0.05171722,-0.015796939,-0.08447454,-0.054136235,-0.05139498,-0.027370447,-0.011094594,0.01937308,0.07452296,0.04943156,0.0679278,-0.07626541,0.07764013,0.017717501,0.027203294,0.008074781,0.006710531,-0.024238743,0.033487543,0.014887418,-0.09554185,0.022393497,-0.0008070653,0.04863055,0.004937953,-0.015553679,0.08509365,0.045811776,0.08147552,-0.035485398,0.041195225,0.0016523593,-0.042509083,0.047429234,0.027526816,0.00076156453,0.013606567,-0.011141929,0.013517231,-0.039134193,0.043209586,0.05867244,0.0027129143,0.011976604,-0.0056713913,-0.005986569,-0.04880805,-0.052414645,0.042824358,-0.009815149,-0.05127131,0.06037618,-0.19627616,3.308839e-33,0.013953522,-0.09523681,0.04328145,0.09774092,-0.024687042,-0.061919697,-0.01676234,-0.023436802,-0.037222393,-0.028762229,-0.052694283,-0.0074494216,0.08291136,-0.007149959,-0.020762112,-0.084482,-0.024940846,0.045044716,0.013948031,-0.012229048,-0.038284175,0.09873793,0.047620106,-0.045914166,0.095534846,0.00093531364,-0.019335441,-0.006375182,0.048041448,0.008145268,-0.012815024,-0.14160061,-0.1167022,0.054856453,0.002400955,-0.029304536,-0.0448446,-0.085400574,-0.006042615,-0.01826828,-0.022966966,-0.0093422625,0.031527556,-0.10542423,0.05290162,-0.05662724,0.05149801,-0.009314737,-0.071587734,-0.017009683,0.032610957,-0.016111568,0.04428284,-0.02397694,-0.07999809,0.030939473,0.0210642,0.044058543,0.056380853,0.024446744,0.008486067,0.045805342,-0.06459715,0.019539155,0.00221199,0.082631156,-0.13084824,-0.08082043,-0.010872779,0.06876056,-0.03337367,-0.027647149,0.07149619,-0.0011671468,0.05662644,-0.008491988,-0.021885695,-0.008626471,-0.06344781,0.14290226,-0.016384969,-0.04385522,-0.014606301,-0.008442317,-0.12400603,-0.044036962,0.0557327,-0.06909761,-0.0041781412,0.00039289598,0.09159451,0.01242245,-0.03633054,0.011149882,-0.030446544,-4.272494e-33,0.048032727,-0.0600568,0.040479753,-0.06858844,-0.03544783,0.044876453,-0.023969362,-0.0075757364,-0.08723134,-0.08972174,0.06912495,0.003494931,-0.0072910693,-0.089763016,0.046167716,0.002454626,-0.031085996,0.04936998,0.0017848889,-0.028558858,0.0098906085,0.045386784,0.085872024,0.06449807,-0.014659915,0.006551237,0.0055236206,0.00979774,0.05116516,0.015359157,-0.06222313,0.0011754339,0.012665679,0.090461776,-0.07829559,-0.09467341,-0.00841495,-0.00456257,0.030691091,-0.009338915,0.011812464,0.065016255,0.001744005,0.034101363,0.029713059,0.009797196,0.050715726,0.054896865,0.008412969,-0.043132752,-0.0687738,-0.07997599,-0.029502604,-0.025337795,0.026930207,0.024991648,-0.07177759,0.079825036,0.10315182,-0.025819408,-0.045448527,-0.116328456,0.07914675,0.013520086,0.015317238,0.028532097,-0.08607013,-0.046122033,-0.11914972,0.053583544,0.022215376,-0.04328418,0.016911985,-0.037895523,-0.0167534,-0.06349221,-0.0133137945,0.016071992,0.03331841,-0.05647028,-0.034607656,0.011027099,-0.020107383,0.0147612,0.07922088,-0.05120945,0.05218447,0.12095614,-0.0036487943,0.004743546,0.022522053,-0.0035544892,0.02377383,0.07218715,0.012754251,-4.3593193e-08,0.03546956,-0.042197492,0.026503325,-0.03526286,0.012919864,0.0060097943,-0.048722506,0.04354502,0.08120202,0.043752264,0.044951778,0.0046488433,0.027365835,0.016890302,0.061763093,0.052966386,-0.041634653,-0.009442937,-0.013249854,-0.014041498,-0.016140472,-0.05940188,-0.043923706,0.078636006,0.03819597,0.01257742,-0.048441444,0.057063244,-0.08160567,-0.09950582,-0.008086064,0.033783335,-0.046107635,-0.019440489,-0.0060749543,0.07590119,-0.0356283,0.021132436,0.015017994,0.0069335294,-0.0095534185,-0.06423556,-0.023781026,0.02037394,0.044942886,0.05800549,-0.012940554,0.07178611,-0.048019245,-0.019026833,-0.033087347,-0.025274687,0.029610274,-0.048902877,-0.08854058,-0.009651688,-0.05798417,-0.020910969,0.0056880736,-0.019919766,0.042536337,-0.025829626,0.07450794,-0.016881626 +3.6.4.10,This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin.,384,1.0,-0.12946452,-0.12291358,-0.04956918,0.03163222,0.057239063,-0.008836677,0.030776652,0.01605313,0.07508809,-0.0520162,0.01217805,-0.06105522,-0.055398617,0.052419502,-0.023106229,0.0077789137,-0.066166416,0.015013225,-0.059690583,-0.043630652,0.0088830665,0.010112773,-0.06752305,0.06787109,0.036764007,-0.01955253,0.06590573,0.039272204,-0.046308037,-0.04956661,-0.00724268,-0.06449953,-0.045580514,0.06492012,0.014729364,0.12644994,-0.025010083,-0.025802113,0.05690278,0.0019067831,0.09218241,0.006069781,-0.012553729,-0.0643306,0.040561676,-0.01399947,-0.05634365,0.0024289242,-0.009072666,0.050352197,0.014635987,-0.006868719,-0.015421321,0.06276779,-0.02147855,0.0013142423,-0.10849986,-0.059814498,0.0077195643,-0.0742659,-0.018163273,-0.026091935,0.027533429,-0.0024555738,0.042280596,-0.073345564,0.024439218,0.0031710754,0.085553356,0.0018199196,-0.03290322,0.012808094,0.012946915,0.037554886,0.007242086,0.05277012,-0.04016147,0.028780846,-0.02710543,-0.070863105,0.08257437,0.013605593,0.08718755,0.08849312,0.017390046,0.009907752,0.07728159,-0.023751635,0.01802381,-0.020013329,0.03298409,0.059880108,-0.018756913,-0.073986456,-0.08337587,0.019873934,-0.014075944,-0.002346418,0.008077979,-0.0053455415,-0.03316631,-0.016566167,0.0077742296,-0.082087785,0.018292086,0.024074204,0.005742105,0.040738486,0.06722545,-0.037267167,-0.016262637,-0.041699693,0.07516845,-0.020314202,0.057003707,0.061051358,-0.034865182,0.0135469185,0.041080732,0.06756756,0.01328285,0.054863196,0.053295366,0.07288149,-0.058192115,0.0073217964,-0.09412281,2.8671418e-34,0.070615165,-0.016073257,-0.026706586,0.057391006,-0.029316124,-0.050710976,-0.083740085,0.0640963,-0.06623208,-0.053575218,-0.012257447,-0.010143352,0.07733137,0.013232542,-0.032052014,0.005545604,0.009372611,-0.025564127,0.02951492,-0.019988734,-0.02680687,0.12777059,0.028346874,-0.006868805,-0.015208814,0.039336607,-0.02462381,0.05382304,-0.009891521,-0.011912522,0.060294878,-0.06087179,-0.06921531,0.09186128,0.017277274,0.11582907,-0.01660564,-0.09635531,-0.018513741,0.014117521,-0.052817915,-0.04805419,-0.0417379,-0.034036703,0.057268266,-0.05610072,-0.04663309,0.049941104,-0.035103254,-0.037288517,0.006263476,-0.024248697,0.07648138,-0.07591995,-0.06068544,0.01626261,-0.0070877015,-0.022723585,0.03770571,0.044657573,0.024160055,0.016621323,-0.15219921,-0.055327352,-0.04102493,0.03143899,-0.032888576,-0.03349371,0.05907806,0.06426576,-0.045679554,-0.0029632498,0.009071705,0.04181058,0.052059624,-0.0073695467,-0.023000633,-0.032065406,-0.04669817,0.06921288,-0.043080337,-0.083211504,0.002067468,-0.006482742,-0.10197518,-0.059769515,0.045061707,-0.04149272,0.02032529,0.033806857,0.00051078334,-0.04851284,-0.05718032,0.054976217,-0.017634047,-1.6571587e-33,0.101293206,-0.113017075,0.004827231,0.03242628,-0.11898016,0.09373507,-0.037051868,-0.05175902,-0.03869944,-0.032829534,0.043315444,-0.070414364,0.05517566,-0.0918137,0.059311792,0.0898568,-0.03066222,0.025663612,0.06945064,0.0066164467,-0.06989722,0.110163085,0.04489641,0.03828552,-0.005151551,0.0030908643,0.013756048,-0.011203558,0.059588227,0.11336747,-0.07279817,-0.037505645,-0.016540201,-0.030720517,-0.06829014,0.0005856686,-0.010616385,0.011762577,0.05538896,-0.08066649,0.009869026,-0.029189585,0.038095865,0.09280631,0.0618019,0.03439444,-0.016782166,0.0009101344,-0.10915797,0.035906006,0.036495805,-0.032571215,-0.06252243,0.0019175214,-0.031097312,0.08225441,0.019597031,-0.03645204,-0.003164726,-0.007093934,-0.02553315,-0.04875293,-0.015585113,0.05123872,0.049644925,0.07248565,-0.09671937,-0.006850599,0.07050181,-0.057068966,0.107184656,-0.08668391,0.024713414,0.00052362593,-0.008760993,-0.009799566,-0.083999224,-0.053720515,0.02953613,0.040324055,-0.075369805,0.015157667,0.008174236,-0.003157207,-0.029043347,0.0031180936,0.017114421,0.084461674,0.009667431,-0.039527554,0.06817156,-0.047539514,0.044150084,0.051516294,0.02007329,-3.612243e-08,0.03509606,-0.052055553,0.060309928,0.0024159274,0.0055843415,0.021219455,0.01555863,-0.041897427,-0.0074379994,0.08741083,-0.021031259,0.06792517,0.0066802707,-0.006155536,0.047981553,0.07234301,0.012636866,0.0696756,-0.02928602,-0.03107014,-0.07558586,-0.0011531778,-0.04684637,0.048647292,0.006068679,-0.03405544,-0.02712534,0.05706148,-0.036605597,0.0053552603,-0.030612707,-0.023585932,0.048621282,-0.07613811,0.0016521147,0.12609361,0.0038992479,-0.07748218,0.033853415,0.03936793,-0.0036629334,-0.009434067,-0.017460397,-0.031547535,-0.04988821,-0.045702554,0.051310703,-0.03621381,-0.012511558,0.04501856,0.08359709,-0.061027355,0.031248758,-0.004103696,-0.093774594,-0.010745363,0.03462398,-0.13314196,0.028532548,0.015414395,-0.014550775,0.018045587,0.13664213,-0.039937217 +3.6.4.11,"An acidic nuclear protein that is active in the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes.",384,1.0,-0.033678364,0.022531614,-0.021441447,-0.06330698,-0.025471201,0.038762003,-0.0033303902,-0.021660754,-0.0143513745,0.03509824,0.05311623,0.019205904,-0.015913561,0.055758666,0.056704585,0.01459429,-0.010228612,0.004477975,0.015562086,-0.078591645,0.01293242,0.059311878,0.011571261,-0.0606418,0.029619223,-0.013527607,0.008543651,0.04128797,0.021165438,-0.08148127,-0.027747473,-0.011476272,0.013806782,-0.006275599,0.02180252,0.060382042,-0.08818181,-0.005601687,0.052176185,-0.07037729,0.14418992,0.018258162,-0.06485891,0.06401356,-0.079426534,0.0781729,0.065943725,3.3459026e-05,0.041909035,0.033407353,-0.0046211216,-0.06803532,0.028729621,-0.082959235,0.024483291,-0.007093768,0.016778428,-0.026771003,0.029395403,0.016956888,-0.018917091,-0.061528847,0.0040664417,0.01893534,0.13006948,-0.08995251,0.08026837,0.049770057,0.011531358,0.015338197,0.09133418,-0.01227527,0.028283833,0.051169436,-0.030920206,-0.013523845,-0.021951385,-0.051715814,-0.025762869,-0.012455852,-0.05219517,-0.04345308,0.06891063,-0.031238118,0.03079493,-0.047272928,-0.008604504,0.0017771095,-0.021378025,0.06363451,-0.050824124,-0.051281884,0.03878026,0.02034182,-0.01828016,0.013090559,0.024698416,-0.0016673637,-0.099980555,-0.0007905993,0.08719097,0.059688788,-0.010438871,-0.02823229,0.028311698,0.06596197,-0.0804831,-0.01769514,-0.06722575,0.06361052,-0.011508714,-0.042714503,0.023291677,-0.020620584,0.020638604,0.00027009135,0.013154163,0.03775942,-0.0057156403,0.008430762,-0.053676922,-0.0012456876,-0.038674377,0.04217728,-0.074538216,-0.06091632,-0.04340516,-1.45908925e-33,0.019504314,0.0041650645,-0.04717189,0.07711748,-0.07738679,-0.00385011,-0.019450676,-0.049084667,-0.03120582,-0.079210855,0.043546867,-0.017044563,0.0633588,-0.0018178265,-0.07822536,-0.076620184,-0.0006159094,0.0517305,-0.029311582,-0.028212635,-0.08521332,0.025066374,-0.0071498454,-0.040347766,0.021951444,0.0059574265,-0.0645128,0.02073019,0.042740934,-0.030617932,-0.001319618,0.01686904,-0.06992601,0.08208146,0.08229411,0.025279954,-0.048046857,-0.022751033,-0.019023702,0.015204556,-0.07113697,-0.059433836,-0.060039047,-0.06144049,-0.027933836,-0.057623744,-0.00777388,0.03209047,0.0029145877,-0.0020711236,-0.029460013,-0.05664571,0.09783261,-0.07062616,-0.053267732,-0.011668608,0.03859025,-0.04195819,-0.023098426,0.0064223455,0.009737348,-0.07934937,-0.04994499,0.08411167,0.0068999873,0.029087333,-0.11671394,-0.08392905,0.017724076,0.004506669,-0.009587588,0.04965645,0.14276996,-0.0891779,-0.033941895,0.03715946,-0.08482583,0.016576473,-0.11381841,0.076421455,0.09080638,-0.022576345,-0.09883,-0.055849817,-0.052021474,0.028009998,0.09775187,-0.023490386,0.06979021,-0.04460123,0.040005166,-0.03272467,0.03983629,-0.041299347,0.04990178,-1.0409051e-33,0.033629782,0.006438944,0.05583988,0.026432002,0.034155544,0.005715341,0.10579318,-0.021097545,-0.12895489,0.004356576,-0.021104073,-0.08223714,-0.013219499,-0.102294035,-0.010631278,0.045834817,0.021689516,0.060357306,0.017732367,0.014541362,-0.053884257,0.11440968,0.03281256,0.054316487,-0.04135194,-0.027413452,-0.05427383,-0.037417147,0.09995976,0.033202026,-0.08276595,0.069319226,-0.00023720613,0.074810244,0.0061373985,0.02966361,-0.009030705,0.0587333,-0.012076936,0.019805314,-0.030679118,0.1056241,-0.0400448,0.03059117,0.041381195,0.09459918,0.049061704,0.10271109,-0.079550914,-0.056823052,0.033962287,-0.0011642918,-0.07073975,0.016711367,0.007992024,0.023443481,-0.009424075,0.025193267,0.0671253,-0.011897328,-0.07006506,-0.04670763,0.0043833265,0.021147862,-0.04136523,0.013264924,-0.080786586,0.035103146,-0.040130936,0.093782865,0.0090706535,0.020851387,0.11314035,-0.06093651,0.02844895,-0.0080481,-0.031799175,-0.023371905,-0.07765004,-0.040001564,-0.066053264,-0.020830102,-0.060623527,0.05606101,0.068002686,-0.024610763,-0.027440915,0.036045346,-0.058888458,-0.015391872,-0.029199876,-0.027492331,0.016882988,0.100802846,0.05825703,-2.7552183e-08,0.086527266,-0.022444567,-0.0054343636,-0.013384751,0.071915455,0.038641836,0.043305922,-0.020125205,0.09813399,0.044981856,-0.046659004,0.00068656926,0.03826651,-0.017312467,0.009132364,0.062339038,-0.02959673,0.046436798,0.014175985,-0.0401021,0.031766206,-0.0069627855,-0.064758785,0.0926422,-0.029460914,0.15197061,-0.0052673346,-0.010385637,0.00023827059,-0.11504356,0.053018004,0.05526778,-0.018214671,-0.05906471,-0.020418083,0.055181824,0.075184524,0.051486984,0.00018359468,0.03890744,-0.022495722,-0.0025961967,-0.074898496,0.04690362,-0.0030047502,0.032224394,-0.003079143,-0.0023306303,-0.07292685,-0.024147112,-0.04300471,0.059196625,-0.04050075,-0.06015078,0.0012861511,-0.0049784943,-0.009239278,-0.01628597,-0.0361792,0.032034174,0.048879623,0.010152795,0.07164879,-0.13231613 +3.6.5.1,"This group comprises GTP-hydrolysing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. Golf is instrumental in odour perception, transducin in vision and gustducin in taste recognition. At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.",384,1.0,0.02151127,-0.10187971,-0.019887784,-0.021244405,-0.03327374,0.035744388,0.09814978,0.05878576,0.05004398,-0.03495324,0.050540987,-0.026121277,0.020779105,0.05082564,0.004405747,-0.015403359,0.07519663,0.033302143,0.019040585,-0.1043623,0.04518277,0.01755347,0.018046694,0.026989903,-0.04157795,0.025751553,0.018685853,0.00054144504,0.0031788733,-0.084360845,-0.018524805,-0.0038477094,0.040230554,-0.00014040826,-0.04303886,0.015424097,-0.07764422,-0.11649365,0.036479563,-0.036124278,0.049818054,-0.019731166,-0.032753933,-0.04364874,0.005321284,0.06261838,-0.036019675,0.0517101,0.010857889,0.015672894,0.009318571,-0.09698785,-0.008820556,0.071168534,0.045898486,0.03191725,-0.10651184,-0.01842985,0.053754732,0.028198479,-0.052134555,-0.034735247,0.010624143,-0.022479394,0.014382975,-0.049455114,0.0038036734,-0.0025376405,0.0799338,-0.058676627,0.0031175518,-0.020527642,0.03991178,0.021641947,-0.0017141006,0.024832176,-0.025387457,-0.013371917,0.015886007,-0.057405785,0.056142043,0.027922947,0.05888912,0.13253196,0.060112786,-0.06907224,0.010598684,0.03322925,-0.0117594935,0.081334665,-0.046602216,-0.08538315,-0.011491405,-0.054328248,-0.033280604,-0.037861295,0.024577487,-0.07916602,0.016106084,-0.012143174,-0.0050531807,0.047973227,0.056024324,-0.023389274,-0.035165783,0.030320719,-0.017566284,0.058156524,0.024707746,-0.079886,-0.058558475,0.015827322,0.05085083,-0.050028797,-0.050647542,-0.00060243695,0.027731692,0.016673522,-0.0063750832,0.02169092,-0.0055842046,-0.04683585,0.026805744,0.024035975,-0.0253753,0.044817545,-0.0755454,4.9904062e-33,-0.02924508,0.0075028013,-0.03188137,-0.0030418804,0.043419916,-0.0007911091,-0.045023616,-0.000520917,-0.026098914,-0.011262906,-0.08330553,-0.0608171,-0.042947695,0.15669909,0.03949076,-0.024494542,-0.07797376,-0.021459049,0.026115408,-0.075574465,0.0008720435,0.05473538,0.022973282,-0.0052985693,0.0049064904,0.06511783,-0.13387503,-0.063966155,0.03321275,0.006942373,0.056499597,0.009906305,-0.14425486,0.030209163,0.034167487,-0.009570946,0.026107594,-0.06972011,0.014083992,-0.03574063,-0.006075612,0.015313772,-0.047250737,-0.017456662,-0.020618081,0.024600761,0.0098980265,-0.005594755,0.03982011,0.064566016,0.056048594,-0.021268489,0.05842878,-0.031761624,-0.06691158,0.024418142,0.021099452,-0.025526837,0.048342027,0.0059145126,0.009112505,0.13932829,-0.00021017421,-0.020863902,0.00055372034,0.049150135,-0.14660122,-0.15736263,0.02543261,0.001745995,0.013074455,-0.037297696,0.06880407,-0.027148439,-0.013190428,-0.07535311,-0.008981292,-0.013047882,0.017345294,0.03705037,-0.03174356,-0.06512103,0.0062670177,0.02978959,-0.026807778,0.001703075,0.04854623,-0.1276539,-0.008638989,0.048654668,-0.033551376,0.011310861,0.018662633,0.031550452,-0.03244996,-5.7897068e-33,0.022973098,-0.012979341,0.055128425,0.017575758,-0.030502433,0.038158994,0.0008620075,-0.053174444,0.05343556,-0.04471007,0.046666376,0.06576616,-0.020892665,0.017851401,0.021755522,0.026947973,-0.00082198554,0.18392839,-0.06959982,-0.04884517,-0.064639956,0.0472869,-0.0031899307,0.07958579,0.057731207,0.08270879,0.081006184,0.0022505738,0.024270002,0.06745158,-0.0029112143,0.055225685,-0.054324947,-0.020468082,0.06525099,-0.059671283,-0.014689307,0.024404183,-0.08270027,-0.025586722,0.05898056,0.0569362,0.05479761,-0.0010207574,0.076170646,0.078420766,0.021167072,0.014804906,-0.048865028,0.02991768,0.10120852,-0.0068530254,-0.06434637,0.043987826,-0.017145343,0.0048255683,0.025946165,0.010048261,-0.029592436,-0.06875477,-0.0015177274,-0.03105189,0.005357797,-0.014827921,0.053055078,-0.026687995,0.020779226,0.008469476,0.09885279,-0.002274537,-0.029269122,-0.034158085,0.042594817,-0.06808176,0.021828784,0.003263005,-0.1313103,0.017489275,0.020282656,-0.04382759,-0.04038516,0.027955754,-0.009796736,0.0033547564,0.050005186,-0.009812782,-0.028978854,0.07899616,0.08736618,0.031038364,0.036449134,0.021356892,0.002381447,0.009934332,0.04187136,-4.6186347e-08,0.05559218,-0.089487,-0.013550434,-0.015235259,0.016929923,0.040594365,-0.04913036,0.0045264415,-0.032461524,-0.04323207,0.06758493,0.07473951,-0.051686272,-0.01033744,-0.0015585704,-0.0011519418,-0.054358117,0.0639852,-0.026102193,0.012313704,-0.11229886,0.0254224,-0.046741463,0.054767895,-0.029223027,-0.107606925,0.034763943,0.05673835,-0.00666614,-0.09179223,0.105756864,0.06448266,-0.07903925,-0.03881147,-0.020763036,-0.009955289,-0.029199442,0.021943145,-0.036649257,0.037236053,-0.014401406,-0.051029436,-0.04630969,-0.0018702974,-0.12901837,0.023073923,0.061879292,-0.035159435,-0.08815495,0.071054205,-0.0071645924,0.10280896,-0.031010302,0.04820227,-0.07243228,-0.06885424,0.008369472,-0.12709548,-0.05617641,-0.12253453,0.010409373,-0.006979544,0.09427372,-0.0679287 +3.6.5.2,"A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase (EC 3.6.5.1). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).",384,1.0,-0.06726674,-0.12553838,-0.1086702,0.00943753,0.038093988,-0.03062912,0.07425662,0.009523187,0.0063167927,-0.009573814,0.059950627,-0.028477442,-0.051548928,0.051784035,-0.035661396,0.014779458,-0.03874988,-0.039113868,-0.091762625,-0.08917867,0.022394942,0.034660976,-0.04582407,0.029756676,0.0045679966,-0.03914655,-0.036047783,-0.07334516,0.03389644,-0.0295087,-0.09201082,-0.05036041,0.07103641,0.05116889,0.07455341,0.03599731,-0.095905885,-0.052344095,-0.038252745,-0.027576935,0.09584495,-0.026637767,0.01692265,-0.058061242,0.011791978,0.026732445,0.016515564,0.009583779,-0.00064025196,-0.00018931799,0.008465475,-0.12487612,-0.095274165,0.06020931,0.015363653,-0.012519077,-0.114827774,-0.05964312,0.022973722,0.07921619,-0.030999653,-0.030267905,-0.008556706,-0.018730508,0.013568933,-0.020196468,0.011271358,-0.01802632,-0.009619094,0.009011337,0.036257718,-0.031747393,-0.08635396,0.075295724,-0.05226082,0.056287326,-0.042809263,0.09310345,0.049467932,-0.08713401,0.092563964,0.027029388,0.12630552,0.104956746,0.027902963,-0.036584597,0.03369274,0.022960652,0.016367285,0.026998604,0.03658012,0.046579085,0.04465978,0.017375724,-0.055718314,-0.02616766,-0.029639896,-0.07218591,-0.05923627,-0.00019898018,-0.005893281,0.058017597,0.073198415,-0.008290648,-0.08749845,0.023331923,-0.07624478,0.07266525,0.008704026,0.048774697,-0.0038635458,0.06762038,0.028781056,0.021043075,-0.032655463,0.029317228,0.013379224,-0.016458236,-0.006179456,0.047325697,-0.020620188,0.008616224,0.0017658031,0.015970794,-0.06883701,0.04861779,-0.068976596,2.5345677e-33,0.0030005206,-0.0075908015,-0.056711767,0.016912546,-0.03500173,0.007469626,-0.037304647,-0.017039744,-0.0042857737,0.020724077,-0.054030318,0.04094523,0.020590037,0.0229511,-0.011037764,0.07166751,-0.030866928,0.044964533,-0.03172213,-0.025050497,0.008625359,0.073735185,-0.028731193,-0.031232074,0.002931054,0.039106548,-0.13691375,-0.10521893,-0.0101838475,0.01416348,-0.0006577044,-0.065634735,-0.08837272,0.082311586,-0.016209269,-0.0072842236,-0.042465255,-0.14489295,0.006445737,0.034466743,-0.07282456,-0.0036538395,-0.029681532,-0.096026674,0.07133093,-0.014474545,0.06184892,0.017365616,-0.031678982,0.054722305,-0.009661917,0.0046282536,0.0061723934,-0.02317273,-0.03252707,0.033625644,-0.019632986,0.075141996,0.074333474,0.036077585,0.028247774,0.035658106,-0.07955593,0.07486324,0.0128541505,0.058389094,-0.12729527,-0.08185815,0.0016147371,0.12691832,0.022861803,-0.065486655,0.06818132,-0.01682727,-0.028570494,-0.08842782,0.011490399,0.014361778,-0.08162577,0.08283149,-0.050900023,0.00021329327,0.006117987,-0.061516654,-0.080924794,-0.015012372,0.061563842,-0.052815974,-0.06619482,-0.033008397,0.034751438,-0.042024266,-0.031865038,0.065923564,-0.024297416,-4.427736e-33,0.08874546,-0.049870115,0.046916768,-0.06223585,0.0012900719,0.029074209,0.029383807,-0.016041918,0.03248393,-0.023948014,0.026810827,0.07404181,0.021099439,-0.0033874467,0.05654496,-0.08240921,0.0011748351,0.061768867,-0.013653007,0.002525537,-0.037254974,0.055647053,0.07083021,0.0773696,0.032382715,-0.055440962,0.025790205,0.054222472,0.0017845326,0.032920465,-0.08407152,0.07948324,0.01231611,-0.018587748,0.0015714541,-0.012772277,0.067238875,0.016946008,-0.01568569,-0.041890442,0.0064036185,0.06915929,0.06966903,-0.0022252696,0.005476497,0.09768841,-0.026535008,0.09000889,-0.040903434,-0.072185814,0.009727941,-0.04012025,-0.033154655,0.03547709,-0.024636028,0.04498861,0.05804281,0.027636962,-0.0962676,-0.022866173,-0.024101913,-0.058375724,-0.0029039446,0.014609827,0.022601955,0.06940642,0.023001255,-0.00091413996,-0.007836391,0.0863044,0.010827276,-0.040465426,0.03201663,-0.010303756,-0.064526476,-0.00875659,0.002854972,-0.051126365,0.06823908,-0.0924077,0.02464817,0.05100566,0.036373924,0.03318611,0.060184386,-0.021772355,0.005620106,0.1411993,0.088859335,0.08799903,-0.059270073,-0.041234057,-0.0212918,0.030577894,0.032193992,-4.9605408e-08,0.101130724,-0.015953887,0.012790998,-0.03575471,0.038711116,0.02466861,-0.03957056,0.05581434,-0.015380099,0.10722146,0.0077309124,0.056244396,-0.034319293,-0.011676833,-0.038227327,0.05121335,-0.034348026,-0.0151328705,-0.012698763,-0.035215028,0.01769542,-0.018565452,0.020620812,0.06629056,-0.009340155,-0.101257116,0.008759472,0.049523648,-0.06622225,-0.014857568,0.061903797,0.007662695,0.07797042,-0.014751101,-0.05496041,0.009042883,0.010198074,-0.021726191,-0.0030727955,0.0036764184,-0.009628843,-0.036029194,0.04831796,-0.07604666,-0.047948442,0.03355682,-0.031338263,-0.066928945,0.007866729,0.031645533,0.0029277545,-0.046263758,-0.06462563,0.014467849,-0.021167181,-0.06467545,-0.04513381,-0.073919505,0.052020438,-0.040100142,0.0075393924,0.033064347,0.12394797,-0.056975715 +3.6.5.3,"This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolysing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1alpha (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF-1alpha catalyse binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyse the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs.",384,1.0,-0.0016928997,-0.104233235,-0.11742864,-0.06580938,0.07521802,0.017805854,0.014317701,0.030232646,0.016980069,0.033430684,0.0531579,-0.031602215,-0.025919348,0.07071901,-0.010110964,0.008622284,-0.100691535,-0.024683125,-0.0062353406,-0.08764283,0.04702532,0.038669553,-0.024869982,0.009425695,-0.03662545,-0.026765997,0.033839226,-0.030822016,0.01694775,-0.06474919,-0.022360278,-0.038596537,0.027047899,-0.012927879,0.029029723,0.06231288,-0.05833626,-0.09249976,-0.052536454,-0.04830721,0.07128948,-0.00783892,-0.01526997,-0.051598392,0.047452148,0.009757274,0.061092384,0.101680934,-0.007254273,-0.01791279,0.024838487,-0.041961715,-0.051310536,0.014468875,-0.030472206,0.112158895,-0.013153049,-0.066750616,0.041654114,0.052800193,-0.058973573,-0.01148492,0.013588335,-0.043421254,0.047584314,-0.06377804,0.018681055,-0.056705527,-0.058460876,0.035161484,-0.05580436,-0.06366631,-0.08809919,0.069568664,-0.0016416826,0.042111773,-0.039774567,0.015719282,2.3067407e-05,0.018980049,0.033141166,0.0022114033,0.11151969,-0.0076964027,0.025100332,0.021121202,0.04384112,0.023449901,0.06611273,0.021236008,0.05954988,-0.01294842,0.054976396,0.0734449,-0.018917106,-0.0015807562,0.0254552,-0.019415168,0.030428063,-0.049716573,-0.0059516025,0.04552922,0.06777002,-0.05313672,-0.02397503,0.010097534,-0.007218736,0.13514557,0.010032778,0.018345555,-0.007567804,-0.015515672,0.098602675,-0.028891854,0.04478728,0.085340075,-0.045438256,0.005641929,0.04610793,-0.041948784,0.003405977,0.015840096,-0.012181247,0.08859815,-0.072253436,0.05101052,-0.118101045,3.986594e-33,0.010319184,-0.02201546,0.026191644,0.035580665,-0.014776535,0.025073638,-0.058409363,0.002657597,-0.01297863,-0.02132915,-0.10360801,-0.006107146,0.030416235,-0.012435023,-0.027905019,-0.041726097,-0.025185939,-0.015268679,0.0029289678,0.039236005,0.011767108,0.030822942,-0.02123328,-0.013790727,0.0478393,0.035684034,-0.03904129,-0.042072136,0.015363587,-0.0016189743,-0.054248277,-0.10025014,-0.13026501,0.05442357,0.034782685,-0.12908892,0.047586814,-0.067236885,-0.0054330532,-0.0010216978,0.012910849,0.002651455,-0.010380627,-0.06806743,0.020247892,-0.060372334,0.089398056,0.035998918,-0.010963983,0.00728814,0.070603,-0.0152291125,0.06531553,-0.006902573,-0.07481433,0.04332127,-0.0139267985,-0.017970761,0.0977997,0.07291736,-0.036074884,0.031636313,0.004150273,0.05543039,0.010993648,0.044653095,-0.10718548,-0.09394002,0.029353699,0.07300961,-0.021357166,-0.0018550776,0.15569071,-0.0051819715,0.047137003,-0.11770083,-0.0579712,-0.0013723226,-0.035258234,0.07133573,-0.06359273,0.036871783,-0.039766617,-0.001066536,0.00100823,-0.07585858,0.016013667,-0.025331693,-0.06416905,0.027159875,0.027829707,-0.00024588694,0.018000182,0.086953074,0.03653283,-4.9095774e-33,0.11615218,-0.13368522,0.03314163,-0.012331044,-0.03790508,0.05377285,0.0736714,-0.0971851,0.06602518,-0.067808285,0.089856245,0.0478064,0.03005107,-0.020468354,0.06998708,-0.06641838,0.0022631686,0.08467917,-0.078961454,-0.03860587,0.005987581,-0.054634925,-0.019885605,-0.021710485,0.035021696,0.020280885,0.04596144,0.026076648,-0.013856159,0.050170746,-0.082239725,0.045556393,-0.04213516,0.061730143,-0.072021164,0.007347595,-0.00057576166,-0.010255148,0.018402716,-0.018995529,0.03248893,0.089566216,0.023710558,0.0012988946,-0.022237834,0.09359293,0.017934395,0.061574064,-0.01045021,-0.051147927,0.050091065,0.016442547,-0.017074035,0.04259294,-0.02828075,0.022062931,0.051181626,-0.025935479,-0.07582788,0.011268882,-0.0038673116,-0.046740998,0.028017139,-0.0024338337,0.043475557,-0.0019392914,0.0010317084,0.04848958,0.047215942,-0.018493578,-0.0057737506,0.028698033,0.054233517,0.06458161,0.027336622,-0.0064327046,-0.023570023,-0.058880392,0.02179541,-0.109847754,-0.008847313,-0.053409662,-0.025249124,-0.046570167,0.014061444,-0.100241676,-0.013568328,0.08930767,0.050996568,0.049051546,0.0016042836,-0.013878948,-0.028943595,0.089395165,0.09195626,-4.7659963e-08,-0.042707317,-0.024535038,0.022531763,-0.104219645,0.03260293,0.07465976,0.013688252,0.017305594,0.05447534,-0.07141847,0.024188584,0.06011643,-0.021333938,0.026710717,-0.036786705,0.077509485,-0.016727226,-0.022798488,0.0351989,-0.0005486117,-0.035778668,-0.05961669,-0.09797706,0.038058974,-0.060551416,-0.08588276,-0.0015721257,0.0919875,0.01744602,-0.081299655,-0.02555981,-0.03901089,-0.011563419,-0.008063807,-0.032110073,0.027109936,0.007875438,-0.039009746,-0.0813356,0.06468555,0.07956042,-0.026571793,-0.02821272,-0.09301229,-0.03337956,0.0659552,-0.0040450697,0.01149945,-0.038036045,0.04155287,0.022220217,0.023827244,-0.01649442,-0.03594307,-0.07069813,0.0026390965,-0.0598942,-0.10475348,-0.009930249,0.010049211,-0.006391508,0.065930806,0.11645925,-0.04807081 +3.6.5.4,Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).,384,1.0,0.02885218,-0.110983886,-0.04877202,0.026890695,-0.003147018,0.105317615,0.0038822435,0.0017543788,0.07789608,0.0171393,-0.06581826,0.0215159,-0.046645164,0.06525118,0.018283188,0.005745098,-0.063911155,-0.014113539,0.016567254,-0.07562694,0.031252243,0.039165407,0.07975314,0.011784119,0.012636895,0.0041589676,0.03133893,0.008645524,0.023427963,-0.055765755,0.054509044,0.00025289544,0.08902613,0.02719644,0.014226683,0.10882602,-0.02239811,-0.087162055,-0.054217752,-0.09449246,0.08526271,-0.017873736,-0.022556825,-0.021166101,0.027711585,0.01609284,0.019161792,-0.030672936,0.032393243,0.019677779,0.07275769,-0.04837264,-0.09842812,0.08251313,0.0084196525,0.1389573,-0.035472326,-0.009454966,0.037283644,0.03244516,-0.042899255,-0.026900064,0.06964854,-0.008743556,0.066043474,-0.03617288,0.017833075,0.0053253886,-0.008587219,-0.011049254,0.011348633,0.00577966,-0.107043974,0.058542076,-0.027517952,-0.0054908856,-0.05128451,0.00033396026,0.00815558,-0.027322428,0.043938752,0.002386384,0.017986568,0.06233799,0.06232054,0.11144017,-0.020434089,0.010327395,0.00084666617,-0.016881455,-0.032030255,-0.09116217,-0.007008962,0.030559573,-0.008401837,0.0076907338,-0.009464167,-0.009156176,0.034922447,-0.059541292,0.012900365,0.025435137,0.0552465,-0.009708243,0.03433321,-0.0055665732,0.019955242,0.082164586,-0.036870427,-0.039823566,0.03247175,-0.093001924,0.097024485,-0.010641521,0.030146204,0.05352779,0.019585883,0.014866656,-0.01772044,-0.020531002,-0.0026886975,-0.055602245,-0.02851119,0.02942524,-0.023585416,0.009919728,-0.07050862,-5.1559188e-33,0.021037823,-0.052409768,-0.008400036,0.073156886,-0.020917434,-0.0036218367,-0.0049968464,-0.033708327,0.049846746,0.012866103,-0.056073274,-0.0021538537,0.025066251,0.08127383,0.058440346,-0.013470636,-0.03583034,0.062042657,-0.010095145,-0.053367548,-0.019954478,0.0012965939,-0.0045450977,-0.03268118,0.04795547,0.048319425,-0.043510046,-0.032414567,-0.032967295,-0.051586118,-0.019476002,-0.014656223,-0.029073814,0.06536226,0.076729834,-0.016203761,0.021897,-0.025984772,-0.011710696,-0.015666109,0.011204513,-0.019507078,-0.095418535,-0.07033773,0.013082941,-0.010317624,-0.0040571447,0.027734436,-0.01291491,-0.030988215,0.04978005,-0.032871645,0.061021175,-0.09115938,-0.06667643,0.043581713,-0.014442391,0.01784583,0.043799613,0.048554536,-0.0495588,0.081218384,-0.023640735,0.070846766,0.08512244,0.04019662,-0.09377165,-0.07015553,-0.015922952,0.07770588,0.03641179,0.010662255,0.030597413,-0.02564176,0.062352072,-0.0047068703,-0.144125,0.01537769,-0.021427743,0.069312416,0.026125807,-0.16065787,-0.07223692,-0.018056225,-0.04504996,-0.01664203,0.0609284,-0.09902844,-0.08165408,0.013823433,0.07689945,0.10589021,-0.026742246,0.12668532,-0.04608824,1.7685777e-33,0.021041734,-0.030112268,-0.019590825,-0.07963095,-0.056230314,0.09428739,-0.014191084,-0.12385338,0.04044089,0.06889116,0.010885051,-0.029434497,-0.0160486,-0.07247829,-0.023777189,-0.02788448,-0.043519028,0.040587477,0.0127812,-0.011671058,-0.10198043,0.024035588,-0.02775711,-0.011043226,0.059270333,0.027436879,0.08221662,-0.005387273,-0.01245451,-0.031590965,-0.026290191,-0.030978141,-0.021240937,-0.009940152,-0.01865441,0.0061569875,0.019240009,-0.050480787,0.020105919,-0.08336685,0.05743475,0.13496765,-0.0008599277,0.06136554,0.012818638,-0.08396341,-0.04394635,0.09211515,-0.0441336,-0.0659719,0.037342876,-0.026203074,0.001344969,0.016921664,-0.047379877,0.10796521,-0.005887587,-0.028922994,0.051395614,-0.098957516,-0.08980188,-0.064915776,0.029297674,-0.0066070673,0.06573666,0.028731879,0.040349636,0.013995309,0.006446768,-0.057907876,0.063211046,-0.01913785,0.03772223,0.017172912,0.010687948,-0.08528144,-0.04926787,-0.090523936,0.026857985,-0.08261218,-0.10457847,-0.0303228,-0.009383905,-0.057380028,0.046529554,-0.020314088,-0.059516978,0.054904684,-0.012627244,0.039905764,0.02022763,0.00540919,-0.046029355,0.07545655,-0.011723848,-2.9991913e-08,-0.03851927,0.014365747,0.0074511003,-0.10910322,0.060614936,-0.0050552837,0.061823435,0.12269003,0.02921116,0.035831593,0.06131848,0.007566689,-0.036425047,-0.01250407,0.04401062,0.081509516,-0.059142806,0.032154705,-0.021262122,-0.026110167,0.027950577,-0.06225221,-0.06842181,0.07047157,-0.03063835,-0.029919319,0.041049477,0.052306943,0.026212288,-0.0667727,0.0060603656,0.02337227,0.04413478,-0.009425543,-0.028554773,0.0031789378,0.079644226,-0.039504264,-0.0730148,0.12388554,-0.032838132,-0.013906136,-0.033572488,-0.032880794,-0.068772905,0.013024524,0.031033486,0.0019550798,-0.02432683,0.07155754,0.06805075,-0.0011824052,0.0096719945,-0.06624633,-0.12011817,-0.012571551,-0.02364067,-0.038196284,0.01547861,-0.020476436,0.032708738,0.062040385,0.108655795,-0.02337351 +3.6.5.5,An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane 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+3.6.5.6,"An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and 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+3.7.1.2,"Also acts on other 3,5- and 2,4-dioxo acids.",384,1.0000001,-0.051482633,-0.12669224,0.0022055937,0.007202805,0.1156592,-0.008917734,-0.02486232,0.0077275666,0.030209249,-0.021975959,0.014074923,-0.020791277,-0.05670949,0.03829177,0.005574903,0.09275911,-0.050721977,0.020393841,-0.07781454,-0.035114445,0.06490993,-0.014502744,-0.016861092,-0.024147106,-0.041301887,0.0898781,0.049308382,0.040232,0.0029524015,-0.11784892,0.007643375,0.030336907,-0.004192268,-0.016506417,-0.042577412,0.065537035,-0.091177076,-0.046279904,0.058497585,0.03998528,0.058012996,-0.026975708,0.062113874,-0.019359682,0.00056877057,-0.043074295,-0.027989868,-0.022794245,0.08600675,-0.020338293,-0.049861036,-0.016558673,-0.0523026,0.052682895,-0.028709462,-0.012523121,-0.090027854,0.07179527,-0.0105471015,0.0072460263,0.004867096,0.011788215,0.006275975,0.07031093,0.006948143,0.042671964,-0.00042131706,-0.048109382,-0.040969856,-0.031904593,-0.027453683,-0.023442658,0.098213024,-0.012565822,0.021604987,0.04975185,-0.01967597,-0.072739795,0.020967685,-0.027555367,-0.044318266,0.053216197,0.020732606,0.08082079,-0.0075812894,-0.0046814,-0.042976346,-0.10475137,-0.05731983,0.03240152,0.012698867,0.018457107,0.0073588165,0.0029355094,-0.0337415,0.04665495,-0.0018219894,0.010804978,-0.026105681,-0.014255712,-0.0506817,0.06357048,-0.08893368,-0.103437364,-0.040073004,-0.015747864,0.0033347483,0.0055075637,-0.045395825,-0.0018877559,-0.014488635,-0.043743305,0.045653284,0.025816476,-0.022766763,0.0436776,0.07134829,-0.035581604,-0.064202316,-0.07429592,0.05256258,-0.0964178,0.052498516,-0.023077061,-0.096818686,0.022063643,0.003730033,-1.6321438e-33,0.063538685,-0.025646154,0.013994776,0.040604822,0.042596046,0.01239057,-0.104214974,-0.016264772,-5.401066e-05,0.011092878,-0.04759088,-0.0043112133,0.095904864,-0.0009788976,-0.03762413,-0.0061688274,-0.01049895,0.019552073,0.017200654,-0.019410877,0.019590737,0.0755438,-0.08131604,-0.009121104,-0.021308351,0.12423372,-0.013033095,-0.043936256,0.034968264,-0.03288911,0.023328371,0.021562213,-0.07636304,0.04207763,0.006753246,0.094033524,-0.08125748,0.0049702656,0.0025987793,0.032640923,0.034820057,-0.015481337,-0.0716498,-0.027795438,0.07669741,-0.054838564,-0.07592404,0.06290363,0.033510506,0.0490254,0.032452736,-0.02873322,0.104036115,-0.018634813,-0.0027737946,-0.039620023,-0.0054686083,0.011673482,0.057376087,0.08339027,-0.02175917,0.04807068,-0.07302212,-0.002426181,-0.004152685,0.042599853,-0.087845564,-0.010838088,0.0056535327,0.07290574,-0.014547735,0.019927591,0.098196074,0.011863796,0.0039803386,-0.031594936,-0.035126217,-0.016883137,0.031727757,0.09301819,0.02936092,-0.07966807,0.07960823,-0.023223191,-0.10218344,0.036418647,0.00587325,-0.05306613,0.010331211,0.024406437,0.08289808,-0.087877095,-0.0091954395,-0.044573534,0.011353039,-6.02549e-34,0.05433423,-0.08428188,0.01722071,-0.019428885,0.01608515,0.019863566,0.004542548,0.006644007,0.04755968,0.016635705,0.122880615,-0.0005947373,-0.022990903,-0.002714271,0.01816664,0.0838493,-0.022090161,0.0837195,-0.0066096564,-0.0055894894,0.04250022,0.13682391,-0.0060277893,0.101534165,0.08034702,0.045184053,-0.0017218674,-0.05537483,0.058336195,0.06889473,-0.01640414,-0.0033364028,-0.032472588,-0.016072081,0.0100255,0.0058524576,-0.059620857,-0.008072112,-0.0602468,-0.0013831393,-0.040605865,-0.04622584,0.10215329,0.09758219,0.02255686,0.098018825,-0.047563292,0.010304178,-0.076809734,0.014936059,0.008708602,-0.018477492,-0.127741,0.019164212,0.084968664,0.105392046,0.019669684,-0.03646272,-0.022107212,-0.026018651,-0.065892726,-0.054694526,0.021716597,-0.08549291,-0.005028452,0.048971236,-0.042799577,0.07211191,0.034535624,-0.040582713,0.08468163,0.019822793,0.04937878,-0.04673207,-0.07060863,-0.08229956,-0.053012017,-0.036647353,-0.010355026,0.03890964,-0.06681943,-0.0032030172,-6.4442866e-05,-0.057335507,-0.040892582,-0.083322145,-0.024140755,0.077176206,-0.017796855,0.06432677,-0.041477002,-0.0031761883,-0.004451884,0.069054924,0.054588195,-2.3623178e-08,0.042480603,-0.045259252,0.09073141,-0.025828758,-0.07383812,0.03106368,0.086897835,0.09728805,0.027463498,-0.044891108,0.05417504,0.079137765,0.018562958,0.022347191,0.06819149,-0.02612308,-0.06113845,-0.00030569217,-0.03491943,-0.026109692,-0.096571304,-0.045171067,-0.016667094,-0.009144193,0.008457035,-0.07540525,0.015434176,-0.02795404,-0.013205747,-0.035915,0.036129028,-0.013400162,-0.011067859,-0.06755472,-0.03823825,0.038921215,0.002960328,-0.035327308,-0.05841499,0.05040567,-0.03634249,-0.09285307,-0.11773951,0.04559004,-0.03586325,-0.0099049965,-0.044196207,-0.02303291,-0.013582423,0.0032855903,0.02927244,-0.03211123,0.036205098,-0.009366247,-0.05383481,0.019497642,0.042514272,-0.040480442,0.040640857,-0.032949377,-0.00396787,0.03683492,0.20015177,0.036267493 +3.7.1.3,A pyridoxal-phosphate protein. Also acts on 3'-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines.,384,1.0,-0.032900997,-0.13885276,-0.067605354,-0.089096315,0.039641596,0.06034119,0.04155417,-0.05835959,0.07306323,0.060841512,0.07254047,-0.008858633,-0.07787975,0.07318683,0.03452891,0.06565903,-0.093326285,0.03387488,0.009864834,-0.06760953,0.08400865,0.060333148,0.03142391,-0.012644168,0.0060273265,0.1052357,0.06526028,0.06943779,0.030190382,-0.04865156,-0.033737563,-0.04684125,-0.03672968,-0.040117584,0.06507149,0.06667105,-0.13727081,0.016929789,-0.004792154,0.01623022,0.10217306,-0.06725215,0.011096932,-0.015806818,-0.047325667,-0.012153405,-0.0006084142,0.028254628,0.06567142,0.01320336,-0.005341764,-0.04879478,-0.022717267,-0.0065952353,-0.009422716,0.019670209,-0.090295576,0.050119825,-0.01717203,0.009903571,-0.013544507,0.044000648,-0.0076106503,-0.009657434,0.06616702,-0.03199845,-0.021517452,-0.039049823,0.011955564,-0.009950317,-0.017208138,-0.05079493,0.061197717,-0.006940959,-0.023645978,0.04456993,-0.022499232,-0.050242215,-0.03568201,-0.039344765,-0.0010194883,0.026204329,0.04715009,0.105568595,0.03638456,-0.02623015,-0.025518002,-0.01890359,-0.060041804,0.0027989342,-0.0009868533,-0.037634518,0.04675129,0.022119671,0.039513513,0.02395825,0.021627171,-0.042435694,-0.054358702,-0.024747172,-0.023821216,0.07061046,-0.0112004075,-0.03601384,-0.08301982,0.013801626,-0.11134185,0.020170873,0.0032494166,-0.02045499,-0.03428517,0.04284881,0.0047936393,-0.0055716312,-0.0017892963,0.033590145,0.031481016,-0.058789082,-0.020757167,0.029290352,-0.0077602114,-0.032648902,-0.002910488,0.092571095,-0.03379959,0.03758755,-0.06516895,-1.1196114e-33,0.08471639,0.021161363,0.057026867,0.034521095,0.0091427695,-0.014835707,-0.07090956,-0.023909325,-0.025379533,-0.00973653,-0.0200008,-0.0159642,0.10364126,0.014369475,-0.071072966,-0.010102931,-0.079484664,0.045417342,0.10623574,-0.04476784,0.01891571,0.11156796,-0.013086387,0.035777543,-0.06222008,0.025693554,-0.0050768936,-0.0024309203,0.015421425,-0.010650579,0.0039212676,-0.06765583,-0.10784054,-0.004721328,-0.02270629,-0.035176035,-0.07134209,-0.09617802,-0.02410826,0.054341182,-0.022510787,-0.074478425,-0.0329216,0.005513898,0.0023269833,-0.09590072,-0.023330351,0.013285128,-0.036123928,0.031754952,0.1075324,-0.07191494,0.08243425,-0.010257274,-0.113246806,-0.024310755,-0.051728018,-0.033249617,-0.003590228,0.025899604,0.07326498,-0.035366748,-0.031588957,0.03867278,-0.0005492097,-0.016076202,-0.011007807,-0.11168331,0.013922186,0.070945755,-0.018292317,0.007686512,0.100763544,0.006725452,0.027451329,0.009439177,-0.09758192,0.065547474,-0.025560886,0.0801895,-0.008692776,-0.06684425,-0.00084886944,0.0036238297,-0.060850095,-0.031478222,0.023726065,-0.1062711,0.04930593,-0.029891886,0.050118238,-0.10278446,-0.056684315,0.04362343,3.0296774e-06,-9.483278e-34,0.08021448,-0.08913573,0.041237704,-0.027428627,-0.0344479,0.012903534,0.09996187,0.011099166,0.012254603,-0.006992541,0.081034645,-0.027126847,-0.005635892,-0.07508154,0.018848818,0.014717264,0.009416076,0.0025949876,0.05627676,0.05191024,0.014636041,-3.5575172e-06,0.015570756,0.10651978,0.043148395,0.050416023,0.013378452,-0.034550052,-0.028092396,0.07803899,0.017498285,0.022240058,-0.014850605,-0.079635985,-0.07637358,0.039375838,-0.061010465,-0.043349642,-0.03888289,-0.027392035,0.027336396,0.058247555,0.08137319,0.040032886,0.022040376,0.080619484,-0.0035060751,-0.015754327,-0.04388723,-0.082774825,0.004729181,0.034555405,0.033964697,0.002753966,0.03987684,0.06580858,-0.07581552,-0.007976197,0.05548354,0.02517953,-0.026031151,-0.09029444,-0.016025042,0.03604387,0.033884138,0.06308844,0.019503636,0.014785208,0.07880998,0.03779359,0.07437768,0.02340578,0.10806993,0.1109858,-0.023722565,-0.048843153,0.026954861,0.0040159253,0.013358747,-0.04335551,0.006097455,-0.01726175,-0.04118804,-0.05652964,0.022577178,-0.025783148,0.047929708,0.13367532,-0.0018173163,0.0040715626,0.03486532,0.0047033476,-0.057622716,0.041468017,0.067867726,-3.605246e-08,0.07834044,-0.06960736,0.023004975,-0.09045988,-0.052769773,0.00045706972,0.09491201,0.0898377,0.050937917,-0.03602029,0.03347236,-0.017693682,0.048346013,-0.008985973,0.0802014,0.036481317,-0.031352077,0.049314294,-0.016932238,-0.10026828,-0.10117839,0.022316061,-0.060725998,0.008419205,0.023519157,-0.012834414,-0.0032714277,0.0539579,0.0038270904,0.00121034,0.05353593,-0.014709465,-0.003675343,-0.08473189,-0.028154327,0.09009719,-0.020268645,-0.03768474,-0.018292272,-0.0101819355,-0.077708185,0.008284131,-0.0479128,-0.025303356,0.014707571,0.040343303,-0.08009659,0.04015381,-0.020338446,-0.05676962,0.05148011,-0.009245133,-0.03607004,-0.06488243,-0.13297474,-0.0060033966,-0.000528661,-0.08258011,0.01487826,-0.08825647,-0.0075647067,0.0042931456,0.080442734,-0.019563211 +3.7.1.4,Also hydrolyses other C-acylated phenols related to phloretin. Isolated from the fungus Aspergillus niger and the bacteria Pantoea agglomerans and Eubacterium ramulus.,384,0.99999994,-0.12592849,-0.04766452,-0.07726035,0.031131573,0.09876085,0.12334055,-0.04451614,0.064195216,0.0040360843,-0.06754452,0.00012273062,-0.066178955,-0.069675036,0.06256404,-0.097078,0.043792766,-0.028255168,0.06582038,-0.049592674,-0.0567772,0.03830056,0.07682,0.024528332,0.056791376,0.004518359,0.010888041,0.028521048,-0.032348417,-0.01636145,-0.06423134,-0.034403645,-0.0028715099,0.031780276,-0.026755005,0.030509278,0.08503779,-0.047959853,-0.066145726,0.08319129,-0.038341876,0.077597305,-0.0011010997,0.055847157,-0.04799771,-0.013654564,-0.017790504,-0.04822521,0.019185806,0.0349275,-0.016809937,-0.068927296,-0.016403578,0.0064897495,0.01551293,0.02047376,0.059334822,-0.016512858,-0.06120014,0.034518134,0.060408186,0.02844642,-0.032007966,-0.032258764,-0.03174178,-0.13877466,-0.015739623,0.009973031,-0.0079357345,0.04433615,0.0053672004,-0.07403777,-0.04741846,0.06365485,0.049159717,0.014102824,0.09821921,0.011478218,-0.013342811,-0.024939807,-0.048691683,-0.016268784,-0.014629622,0.014397315,0.011240493,-0.004999903,-0.08193151,-0.010215131,0.07655347,0.07088382,0.03599489,0.016489277,0.1004891,0.023718135,-0.0077997334,-0.07859818,0.0029374682,0.07672399,-0.015597687,0.012673655,-0.0021711946,0.018452987,-0.020445246,0.09236731,-0.087278925,-0.043072823,-0.013166766,0.019900132,0.024621997,0.06572777,-0.012119741,-0.0020193355,-0.0007510099,-0.02701012,-0.13485068,-0.0208939,-0.021112299,0.03307121,-0.043867517,-0.028985234,-0.033960175,-0.0013005175,-0.077730834,0.095769346,0.023932299,0.0022913988,-0.009081412,-0.030086078,2.9636534e-33,0.06890514,-0.013387532,0.005916854,0.00894178,0.0008316839,0.013090975,-0.0823577,0.043243192,0.019043474,-0.17604098,-0.04469273,0.05148775,-0.04863103,0.056195725,-0.018626014,0.0035398596,0.074208096,-0.095773496,0.053709283,-0.027651561,0.039196793,0.06291572,-0.093909994,0.060054235,-0.011043776,-0.037187748,0.03080368,-0.012743825,0.05490148,-0.0050868373,0.10438907,-0.058061745,-0.02746256,0.01718248,0.0045115976,0.11193835,-0.08987533,-0.037291087,0.0026231492,0.0853896,0.019807847,-0.028659726,-0.0020552268,-0.017225698,0.0029062242,0.017446375,-0.060430728,0.04502572,0.03474343,0.011525602,0.0006568436,-0.01690159,-0.008815726,0.040380634,-0.029096473,0.0359596,-0.0086561255,0.020527635,0.066812664,0.03871322,0.0016895405,0.08909843,-0.031102054,0.017858654,-0.032230083,0.03912128,-0.031147176,0.059747588,-0.039747998,-0.08758067,-0.060200803,0.032109745,0.09082351,0.045742694,-0.026895182,-0.054082297,0.011081902,-0.041475207,-0.06416327,0.023969263,-0.018525854,-0.031627562,0.047480904,0.03533056,-0.1350947,0.05775364,-0.039102416,0.0717529,0.023127254,-0.05226535,-0.005088683,-0.10041076,-0.013548972,0.048279356,-0.04104942,-4.204397e-33,0.082696,-0.09014504,0.043501563,0.03232952,0.01509457,0.019113181,-0.00057305413,0.024654485,-0.05928427,-0.05728119,0.040106155,0.015014097,0.08645766,-0.025967197,-0.00250415,0.015897356,0.02020586,0.12065468,0.01157893,0.041939285,-0.06538942,0.009696097,0.014097036,-0.013515519,0.0772136,0.06331619,-0.036349855,-0.0026090362,-0.03875342,0.048490062,-0.013075438,0.08297685,-0.030017076,-0.08765624,-0.047962,-0.01935419,-0.030619593,-0.044762548,-0.020643165,0.039796527,0.02259441,-0.04183766,0.01691262,0.015325325,0.056619696,0.10080117,-0.016012756,-0.0070919385,-0.01873228,-0.012048072,0.006915452,0.097092815,-0.060824107,-0.008242386,-0.0028423916,0.026743073,0.05257823,-0.011686352,0.095179625,-0.045519803,-0.03217131,-0.06688583,-0.00041259296,-0.03037697,0.008224428,0.099766076,-0.033538364,0.073809065,0.037007425,-0.073792055,0.015376018,-0.010878005,0.026284093,0.050396852,-0.033049576,0.018924393,-0.044856302,-0.055709906,-0.041220788,0.015121852,0.035531536,-0.035550814,0.07065412,-0.07994482,-0.020769969,-0.02063525,0.020270912,-0.00870894,-0.030552898,0.02886068,-0.032174014,-0.012050303,-0.06797569,0.10228498,0.063608736,-3.281425e-08,0.05628859,-0.037915193,0.054840233,-0.039224096,-0.012273856,0.0316741,0.027939018,0.049298286,0.03600798,-0.040604144,-0.15042074,-0.02504902,-0.03470337,0.01959618,-0.002688094,0.07108027,-0.041875686,-0.0498546,0.005518531,0.0516414,-0.084239826,-0.018707557,-0.026433539,0.06120845,-0.06624021,-0.023515573,0.04106029,0.015900044,0.023701862,-0.05755215,-0.023584306,0.06088439,0.018672938,-0.029125819,-0.003423647,0.024919134,0.02365693,-0.085980035,-0.09187466,0.04024004,-0.0271823,-0.06654768,-0.043592192,0.025941098,0.018335663,-0.05578768,0.012422158,0.063548625,0.025576593,-0.04973883,0.033977747,-0.010059962,-0.009263316,-0.028469672,-0.05141646,-0.03276242,0.0872567,-0.07215461,-0.08160121,-0.03160128,-0.07543829,-0.0506376,0.15052839,0.066547126 +3.7.1.5,"Acts on formylpyruvate, 2,4-dioxopentanoate, 2,4-dioxohexanoate and 2,4-dioxoheptanoate.",384,1.0,-0.036426857,-0.07696362,0.017616095,0.054580722,-0.018667383,0.036282405,-0.031493623,0.029280813,-0.019840369,0.024821583,0.040946636,-0.082600355,-0.08851018,0.08876098,-0.017994637,0.15283585,-0.103098206,0.016719077,0.032520436,0.043437738,0.043748897,0.029710071,-0.012634022,-0.022194125,0.022555804,0.08166883,0.053086277,0.049961336,0.08431091,-0.09997014,-0.009108102,-0.033361685,0.025431983,-0.07593336,0.06877511,0.065171994,-0.042068217,-0.010580947,0.037783105,-0.023027727,0.04879767,0.0017775224,-0.0075007654,0.061055545,-0.00067812356,-0.010780719,0.038942505,0.0034055477,0.029739045,0.010929343,-0.016757784,-0.02939979,-0.09083211,0.11594597,-0.006407544,-0.040029176,-0.06786356,0.054960113,0.0011172978,0.028464843,0.013314229,0.022758871,-0.03122971,-0.005345211,-0.041145034,0.04248816,0.012978818,-0.024280544,0.016902547,-0.10380297,-0.047095113,-0.008735584,0.07960912,-0.050546303,0.0014950219,-0.005497826,-0.014321407,-0.049232915,0.017494436,0.0058867903,0.061057877,0.02865213,0.045244925,0.012413135,0.037996713,0.01718815,-0.041940752,-0.092919104,-0.008226399,-0.0065139863,-0.033319835,-0.014598346,-0.05907572,-0.050598662,-0.013597333,-0.0019660636,0.02329788,0.048037034,0.10426808,0.059444513,0.012335997,-0.00957729,-0.09709282,-0.098323755,-0.014121611,-0.012301927,0.033677515,-0.03663238,0.0015624284,0.03821337,0.020753223,-0.04928491,0.07349021,0.0350175,0.0051100967,0.08361767,-0.030315813,-0.042658903,-0.04494233,-0.020317232,-0.0026817622,-0.044029452,0.108847074,-0.046377182,-0.1501771,0.016077377,-0.025159575,2.817822e-33,0.08658474,0.027737347,-0.0079570785,0.044555217,0.058240455,-0.06982102,-0.09615384,-0.010486578,-0.06838494,0.0026716052,-0.061251726,-0.0726475,0.073032126,0.0012691136,-0.08940342,-0.06901117,-0.022451924,0.07299498,0.011848997,-0.048009805,0.043520547,0.111679345,-0.014225458,0.04397564,-0.0120177055,-0.016133048,-0.02626909,0.013716901,0.025956742,-0.01925643,0.019339155,-0.080451354,-0.07682035,-0.0051697376,-0.012213539,0.026748016,-0.050160084,-0.09044268,0.01902463,-0.01434476,-0.027043486,-0.023728888,-0.08697623,-0.044153433,0.067826904,-0.07405668,-0.012747201,0.11702797,0.056253143,0.04268366,0.04060616,-0.03837985,0.030049002,-0.030922266,-0.058738183,-0.0035015494,-0.0113605065,-0.011475371,0.10801591,0.013462379,0.0041243546,0.061770517,-0.07340166,-0.07189507,9.30052e-05,0.0053622904,-0.06066982,-0.028530942,-0.057077963,0.011805467,-0.012209178,-0.06008543,0.023770096,-0.003948068,0.06817839,-0.030152993,-0.027499517,0.049818255,0.034639128,-0.01451381,-0.020608502,-0.025475832,0.026888475,0.005997682,-0.055021785,0.0020753327,-0.0020424933,-0.03142251,-0.013009889,0.062127747,0.00719913,-0.023378575,-0.04528528,-0.032028165,0.04846745,-3.0465897e-33,0.009515722,-0.048842218,-0.028448723,-0.026181035,-0.010138203,0.04679794,0.0012568011,0.027703185,0.07106138,0.021233885,0.113809586,-0.014820324,0.046590265,-0.007872937,0.009183785,0.021810826,0.0099701425,0.05755159,-0.0056495336,0.045568667,0.07384092,0.06808266,-0.06540745,0.073715776,0.06709767,0.032263543,0.043490727,-0.026075987,0.08608789,0.09135087,-0.055195402,-0.023359723,-0.026751863,0.013792183,-0.008528075,0.040726062,-0.06309966,-0.037318677,-0.11084064,0.035371657,-0.026330264,-0.013398892,0.03645698,0.16812432,0.045201093,0.03309801,-0.095239915,0.004869389,-0.0071683116,-0.008679205,-0.029921519,0.035717405,-0.100467965,0.030038446,0.0092342775,0.11263577,0.020336049,-0.03433944,-0.011354086,-0.033149138,-0.030203044,-0.10006619,0.058036365,-0.05151189,0.09243953,0.015365229,-0.047889996,-0.0029576053,0.006651399,-0.044169758,0.014291591,0.0031564494,-0.0047641657,-0.050720826,-0.002012922,-0.026886642,-0.0011383559,-0.10014752,-0.035024226,-0.014843653,0.008593588,-0.0018466302,0.061637394,-0.050097097,-0.015588558,-0.024001671,0.020624936,0.07627408,-0.019907126,0.035351478,-0.005606303,0.055959016,-0.029324062,0.018963844,0.05284766,-3.416875e-08,-0.04039459,-0.029627677,0.12627499,-0.029887164,-0.053168852,-0.01750328,0.07202947,0.065280974,0.009514805,-0.07698313,0.08170454,0.07643382,-0.003142595,-0.08115165,0.07415302,0.031241402,-0.06664796,0.080328755,-0.076480046,-0.032142382,-0.045611314,-0.073888056,0.0041206805,0.0048946464,-0.004668829,-0.0795243,0.029460154,0.043647703,-0.051820863,-0.021016143,0.065022215,0.057105213,-0.036344483,-0.09311351,-0.09298593,0.013138267,-0.018221773,0.0053915717,-0.0720815,0.050150685,-0.0101580415,-0.030807564,-0.047805514,0.05711541,0.010880964,0.018497853,-0.007763416,0.026983673,0.012788934,-0.010457175,0.05121812,-0.022894941,0.005943848,-4.901435e-05,-0.072514884,0.07494995,0.002537966,0.067991465,-0.0023840452,-0.03195359,-0.028517526,0.06382324,0.18264557,-0.01208914 +3.7.1.6,"Highly specific; does not act on pyruvate, oxaloacetate, maleylpyruvate, fumarylpyruvate or acetylacetone.",384,0.99999994,0.015535018,-0.06267804,-0.06948341,0.027992241,0.03899247,0.029238274,-0.038074348,-0.0063028177,-0.008291426,-0.011460106,0.005798726,-0.01936949,-0.10404542,0.08522706,0.010247998,0.05592297,-0.029709699,-0.03467917,0.06288485,0.032016963,0.08103456,0.07013687,0.04229388,-0.060988232,-0.038285337,-0.01881482,0.016313909,0.0761624,0.009083681,-0.068854794,-0.05702864,0.030594122,0.034544114,-0.012150302,0.07733131,0.08497353,-0.13562454,0.011027295,0.10203173,-0.0009980514,0.06281372,-0.01681747,-0.029605618,0.015097862,0.014294331,-0.016025303,-0.0074621835,-0.04626807,-0.0724986,0.073141664,-0.04610134,-0.023721358,-0.037739526,0.1276201,0.020122483,-0.0120704705,-0.048033882,-0.03063979,-0.027262859,0.007937178,-0.055895362,-0.028802224,0.0048179384,-0.024789385,0.012129538,0.01820533,0.05164211,-0.10143819,0.010425496,-0.05570399,-0.037564408,-0.07175069,0.05553366,0.10122964,0.025235232,-0.002979187,-0.0243434,-0.060681313,0.01738028,-0.019791083,-0.06278368,0.0009723167,-0.0047302516,-0.0016451328,0.070750855,-0.009236341,-0.03802783,-0.042938326,-0.03420825,0.114114635,-0.056568403,-0.03490269,0.04661386,-0.051927876,-0.035794534,0.022256494,0.07192355,-0.008681051,-0.015650373,-0.024462825,0.002214303,0.024161758,-0.082109645,0.007139825,-0.025008738,-0.00053280836,-0.015890429,-0.036675043,-0.025247984,-0.0027140707,-0.032343354,0.033160854,0.09244677,-0.049004257,0.0038825646,0.013540539,-0.0012323557,-0.03941388,-0.04096175,0.051554024,0.013501514,-0.05299675,0.055003755,0.056392558,-0.1127224,0.037865788,-0.10920991,4.4328983e-33,0.06382311,-0.035711654,0.005159805,0.020884382,0.02780986,0.03857297,-0.05744636,-0.06213362,0.041918736,-0.028072257,-0.01627163,-0.027144099,0.104560785,0.054967828,-0.072501644,0.032523107,-0.04342547,-0.013666995,0.0490412,-0.075195715,0.006355734,0.11217667,-0.027647097,-0.05794062,-0.073191464,-0.0045160693,-0.04602167,0.11074133,-0.011902334,-0.018944874,0.0052783657,-0.100113414,-0.02846347,-0.006157625,0.030650185,0.07229981,-0.10748253,-0.049378,-0.01910289,0.03935031,0.027907195,0.040673833,-0.05118477,0.011225354,0.01058315,-0.08289051,-0.010509177,0.122237474,-0.04623593,0.024990197,0.05947261,-0.021437617,0.09986964,-0.05158901,-0.0020620544,0.0633038,-0.0352165,-0.020171676,0.011358387,0.057867337,0.07480191,0.0035712263,0.013746667,-0.012538086,-0.047561035,0.027461909,-0.08332963,-0.045084454,-0.048059873,0.06765077,0.001577881,-0.004772714,0.12655742,0.036480516,0.06437256,-0.016843425,-0.058132205,0.068153776,-0.02126407,0.015895387,-0.046585616,-0.068109445,0.021597784,0.02867088,-0.07855893,-0.028307801,0.0071213874,-0.048501298,0.014193564,0.00811968,0.020850722,-0.052879468,-0.00815568,0.023941498,0.031471364,-5.9557266e-33,0.008179579,-0.048977576,0.036141388,-0.063870594,0.018289676,0.04376706,0.018418657,-0.04093145,0.031816237,-0.004752222,0.0986535,-0.045441724,-0.032112993,-0.07141936,0.018701041,0.043860365,0.008056777,0.06609205,0.002149252,0.0070329914,-0.055209514,0.075291924,-0.09157962,0.092028454,0.044324882,0.07841151,-0.048540518,-0.055453017,0.025059877,0.028504228,-0.017469887,0.053220734,-0.0757633,-0.03837965,-0.012152283,-0.023875026,-0.07802394,-0.02069955,-0.05572861,-0.0132913245,0.06078247,0.056852896,0.026683941,0.12846468,0.05059089,0.03656939,-0.020144489,0.0050156503,-0.026997527,0.050604038,-0.037404284,-0.004288299,-0.052903596,-0.017411217,0.09719345,0.05792443,-0.02847549,-0.057180967,-0.033174623,-0.016300807,-0.07366612,-0.031632934,-0.017228106,-0.00028039102,0.05145445,0.043633226,-0.006031941,-0.01827502,0.0901678,0.011446646,0.108035035,0.02938282,0.002549764,-0.05118208,-0.039794844,-0.01495694,0.014875638,-0.03091988,-0.04333726,-0.037901353,0.029978257,-0.013201218,-0.015578968,-0.04669158,-0.06784272,-0.01771134,-0.06932327,0.031269524,0.013013185,0.013244839,0.005170621,-0.039865136,-0.07140931,-0.03788192,0.052988976,-3.2285342e-08,0.039153304,0.0013020479,0.050853033,-0.050039828,-0.04491805,-0.011910527,0.030392429,-0.014971503,0.039100338,0.00019708973,-0.0010092292,0.088369995,0.11073303,-0.054167382,0.07088563,-0.06417722,0.0023336473,0.11568036,-0.059024677,-0.040779002,-0.09100397,-0.024835156,-0.044913854,0.08156217,-0.00600733,-0.072732046,0.037179068,0.005136089,-0.013740858,-0.06791353,0.076786116,0.06308677,0.016536944,-0.083502516,-0.023919955,0.04153579,0.07600158,-0.053399738,-0.030074142,0.068419084,-0.009768602,-0.07684127,-0.037508085,0.058777776,-0.0023992758,0.007341154,-0.045588236,0.016539128,0.007494069,-0.01866683,0.045406517,0.06355917,-0.029630058,-0.034960106,-0.09038445,0.05089653,0.010401154,-0.011197718,0.011513992,-0.10379433,0.10364603,0.0009529223,0.15963383,-0.053406347 +3.7.1.7,"Also acts on the product of the action of EC 1.1.3.18 secondary-alcohol oxidase, on polyvinyl alcohols; involved in the bacterial degradation of polyvinyl alcohol.",384,0.99999994,-0.06281198,-0.08786091,0.03119899,0.039942093,0.15630485,0.02423041,-0.008866077,0.028334023,0.06864836,-0.06130987,0.04495012,0.0277186,-0.07523472,0.07802521,-0.020238806,0.029084615,-0.103800945,0.0521727,-0.024684625,-0.0011003286,0.051259633,-0.049278572,0.026222704,0.0028835807,-0.011010079,-0.0031926734,0.058780793,0.0366986,-0.049844716,-0.048964184,0.10062824,0.002588116,0.09104237,-0.050012227,0.05005393,0.023028258,0.03623429,-0.13840352,0.032187227,-0.03503305,0.068993874,0.022844668,-0.011289011,-0.0800882,0.03285502,0.015813373,-0.02939142,0.0044972226,0.011666108,-0.022372825,0.06161215,-0.02535058,0.01624281,-0.03945123,0.07459696,0.016549094,-0.010328828,-0.022096574,0.0011370828,0.034401923,0.055510405,0.009951965,0.038470674,0.058158293,-0.07496394,-0.07120259,0.1501317,-0.07215906,-0.07003854,0.0055135074,-0.10123432,-0.09197353,0.025179474,0.029701147,0.028635113,-0.009614563,-0.03598138,-0.10924911,-0.035218593,-0.058355533,-0.030917713,-0.04220487,0.0061416137,0.053753518,-0.016835533,-0.054673813,0.017130276,-0.10490456,-0.0014918891,0.099230245,-0.045966078,-0.064011045,0.032162696,-0.0013411767,0.03068166,0.0073090247,0.056274876,0.0672085,0.048467126,-0.018588793,-0.10337961,0.11205016,-0.014996238,-0.12228004,-0.003773757,-0.003996044,0.02005711,0.045467038,0.046379976,0.05277744,-0.007650011,-0.060503833,0.0023905258,-0.034343526,-0.0101563865,0.10742441,0.064507306,-0.0139934085,-0.08340329,-0.031047173,0.003718854,-0.086525135,0.047796078,0.053628933,-0.08604308,0.007173927,-0.0037327749,-1.6444617e-33,-0.013117322,-0.045904852,-0.06748961,-0.04132897,0.029219473,-0.07728642,-0.036025666,0.009314649,-0.025849931,-0.07387401,-0.032492217,-0.031559914,0.049546923,0.022104926,-0.0004170076,-0.0086821085,0.0076566054,-0.00061253295,0.03290316,-0.04337954,0.026518341,-0.015247303,-0.018133707,0.032263774,0.028284214,-0.041466907,0.059884362,0.022650663,0.024690399,-0.030671988,-0.017692374,-0.038892206,-0.07101174,0.022466244,-0.0064002136,0.07923714,-0.0049557686,-0.0069419,-0.012300976,0.045213915,0.03395722,0.08351811,0.049366754,-0.0657064,0.009894554,-0.019498488,-0.025723116,0.110345535,0.06192931,0.08291749,-0.015971439,-0.028228123,0.044169445,-0.033026546,0.00484978,-0.0017708609,-0.04706354,-0.018631978,0.003047982,-0.02394259,0.020834582,0.06455866,-0.04967777,-0.02777207,0.003920944,0.08100958,-0.0023583614,-0.072561905,-0.0097004045,-0.065976344,-0.08555085,0.042272776,0.01565784,-0.034803916,0.063052565,0.017327543,-0.10955844,0.022381281,0.09308755,0.016716164,-0.096811146,-0.0033732476,0.040098786,-0.024788626,-0.008868415,-0.019445112,0.008695676,0.038743533,-0.0038064094,0.044316486,0.09820146,-0.12089206,0.0029886325,0.07142076,0.011347897,-4.3750224e-34,-0.009073116,-0.07009699,0.019611511,-0.043173857,-0.019439565,0.02360463,-0.02362371,0.046027392,-0.012096626,-0.048932645,0.06741257,-0.023979994,0.0064195897,-0.017542858,-0.008444748,-0.032167416,-0.03747408,0.06542512,-0.07029734,0.015561538,0.05147103,0.010984951,0.0766455,0.014980717,0.020255588,0.025218114,-0.0060975994,-0.007924329,0.018341148,0.0005688218,-0.021054508,0.0038638138,-0.019581243,0.018394688,0.0087602725,-0.009100933,-0.04436632,-0.043839887,0.012580922,-0.04469169,0.057152357,0.026552537,-0.026111597,0.010798156,0.044963237,0.097597934,-0.04537431,0.022287102,0.024302486,-0.04806032,-0.018943565,0.052066967,-0.023697104,0.030788895,0.026759665,0.053435046,0.052372135,0.029825877,-0.05946137,-0.019729115,-0.030726291,-0.0050724135,0.08018231,0.037363205,0.029550524,0.03744166,-0.052314017,0.15445723,0.038938943,-0.041540727,0.08615468,0.016704556,-0.012366977,-0.010100951,-0.04875306,-0.15138246,-0.062477794,-0.03690621,0.0074062357,-0.002829556,0.0252304,-0.003558134,-0.07224995,-0.020191813,-0.0078108995,-0.061122917,0.046824064,0.013392967,-0.048382472,-0.014097873,-0.032056767,-0.006802186,-0.1004286,0.056240138,-0.011833618,-2.9426356e-08,-0.045948252,0.013499722,0.080713905,0.021815637,0.042245857,-0.0025738336,0.015689984,0.04180302,0.0024897149,-0.0574402,0.019256098,0.10955243,0.03425017,-0.06565374,0.066827446,-0.07230805,-0.104606315,0.011165393,0.018655157,-0.04156642,-0.01629049,-0.012334983,-0.04484234,0.030964822,-0.018795386,-0.055020325,0.052873753,0.02455792,-0.03661728,-0.078658625,-0.0012103642,0.055883057,-0.030953841,0.04198888,-0.013590979,-0.005409655,-0.013846652,-0.02017679,-0.0673324,0.091642134,-0.015817735,-0.052397948,-0.11144125,0.017182475,0.10608112,0.07764181,0.005824244,0.0065731304,-0.070212975,-0.038551368,0.06643083,-0.04285309,0.03649668,-0.004515815,-0.10263145,0.045602053,-0.018690728,-0.05414362,0.008813344,-0.020391658,0.040297803,0.0139511265,0.16345283,0.079189315 +3.7.1.8,"Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.",384,1.0,-0.054607358,-0.068303674,-0.011030847,-0.05009227,0.025304763,0.020705052,-0.040461488,0.04393805,0.04755621,-0.039012156,0.062738426,-0.10051755,-0.052259322,0.007855875,-0.030244399,0.08227757,-0.06252015,0.07925567,-0.046853315,0.04107078,0.04224368,0.048716277,-0.043578498,0.08688561,0.021456603,0.083065756,0.10089683,-0.008347328,-0.05240993,-0.039604392,0.006509451,-0.06470519,0.119308375,-0.071627215,0.09511678,0.051443156,5.7942827e-05,0.017361734,0.11708304,0.02696698,0.003891475,-0.002391712,-0.023799585,-0.072836444,-0.03210162,-0.056300376,-0.043049086,0.03741805,0.07140953,-0.045173153,-0.05916964,0.030632006,0.02247017,0.08052492,0.07292417,0.038401302,0.034998,0.03318696,-0.06606132,0.052558586,-0.013693917,0.0071830107,-0.040613767,-0.00903885,-0.08169,-0.018945375,0.04203552,-0.03212752,0.04928204,-0.042099174,-0.074376605,-0.032390613,0.032126334,-0.042302173,-0.012776756,0.062147442,0.03432775,-0.10810536,0.0058196783,-0.09240616,-0.052700154,-0.07566516,0.023777857,0.009354787,0.04113431,-0.08672969,-0.03236987,-0.016987992,0.017378254,0.07064039,-0.049180385,0.044090416,0.064397395,-0.05921729,0.03777403,0.1225387,0.036685295,0.020167489,0.050208565,-0.008510443,-0.00093043427,0.039920785,-0.008608376,-0.14851469,-0.010326235,0.0063606445,0.0064941454,0.07224329,0.03308031,-0.01819694,0.06386106,-0.049841266,0.057410665,-0.033839572,-0.03544019,0.10777306,0.071476825,-0.058609538,-0.00839407,-0.001642899,-0.014966192,-0.080273636,0.04936344,0.020855147,-0.06709154,0.021680495,0.03658897,2.3175955e-33,0.07235983,-0.0029598759,-0.06938422,0.064090624,-0.055625,0.02920307,-0.11154629,-0.00060630473,-0.0111822225,-0.14539985,0.016443705,-0.0021270013,0.039282013,-0.022328978,0.008112013,-0.030961046,-0.04312611,0.04367107,0.08135265,0.018162252,0.006501942,0.009861682,-0.053289507,0.028987702,0.022942068,0.006467863,0.010115198,0.0061648837,-0.032437306,0.014890327,0.050358746,0.021367528,-0.0760799,0.0023086346,-0.007905481,0.022441056,-0.060666554,-0.027644683,-0.041899342,0.089179434,0.052418243,0.00081614306,0.016931769,-0.057994053,0.06860587,-0.01766493,-0.035959933,0.11005183,0.0029257336,0.12608701,-0.0052258936,-0.031695828,0.04649205,-0.0039649094,-0.029528327,-0.032291442,0.014324471,-0.019081818,0.14168529,0.05076648,-0.03591333,0.16916272,-0.023762045,0.039085448,0.035527416,-0.05118251,-0.0634524,-0.009073252,-0.017016076,0.022765765,-0.04802279,0.00033979354,-0.0051441793,0.003617774,0.0075844987,-0.053377062,-0.11465802,0.018366884,0.016685907,0.040622067,0.012357008,0.040254686,0.042350587,-0.07628906,-0.0995154,0.08283877,-0.05555493,0.00526778,-0.053391803,-0.009373411,0.049823824,-0.068226,-0.029880725,0.055208046,0.014511803,-2.3928459e-33,0.03699246,-0.09133183,0.031673275,-0.047965385,-0.051506758,0.040126,-0.061523434,0.028023379,-0.013197748,-0.015689636,0.05626973,-0.007858447,0.017382162,-0.0052172476,0.0081003215,-0.02940988,0.08372222,-0.01581265,-0.013855654,0.016329562,0.10949982,-0.001086745,-0.060499366,0.12114177,0.020678667,0.029080568,-0.015210432,-0.02128172,0.06809111,0.10148018,-0.023933817,0.08867703,-0.022041794,0.030747691,0.023546623,0.053476598,-0.11529217,-0.017502965,0.052004915,-0.01580379,-0.033576157,0.008061705,-0.057608474,0.012946419,-0.008484366,0.026601752,0.0062502283,-0.03464702,0.0011767185,-0.05515783,-0.03686165,0.018083515,-0.026249394,-0.011873706,-0.050681524,-0.0239038,-0.051141504,0.026544243,-0.014213421,-0.0699651,-0.08978313,-0.010262703,0.056346506,-0.020137182,-0.004998909,0.05768174,-0.03391086,0.07304856,0.017428676,-0.04740708,0.041255325,0.003944609,0.026123568,0.027075062,-0.084408574,-0.045373213,-0.02168927,-0.026968943,-0.0017926231,0.038341586,0.11001295,-0.029863104,0.019997336,-0.0266993,-0.05682919,-0.09982715,-0.021643987,0.01859952,-0.08383824,0.008957465,-0.007666082,0.02524093,-0.031109516,0.06852905,0.09416306,-3.9221405e-08,0.046918724,-0.034394078,0.09107376,0.05427729,0.022935208,0.03229729,0.015984116,0.066306286,0.0014998943,0.0098401075,-0.022764195,0.03168686,-0.04353632,0.052642718,0.031715523,0.046058357,-0.044228867,-0.007796618,0.018927447,-0.057868678,-0.03822647,-0.06846337,-0.02252391,0.0081413835,-0.03450261,-0.036500767,0.022693053,-0.017114049,0.041141495,-0.01361567,-0.015364427,-0.010547579,-0.054524686,-0.01742515,-0.0036651948,-0.03297062,-0.0308095,-0.02362447,-0.08192739,0.019350484,0.01793431,-0.019442169,-0.11693822,0.0014332063,0.028173057,0.005755039,-0.01211363,0.06322529,-0.02159956,-0.040909503,0.08294673,-0.07118987,0.095710844,0.0115352515,-0.072487645,0.02978656,0.03149406,-0.050357006,-0.023079146,0.0018086549,-0.028169615,0.05773911,0.089293905,0.0319766 +3.7.1.9,The enzyme is involved in the degradation of catechols.,384,1.0,0.020563995,-0.048737638,-0.08053157,0.0043702945,0.025699541,0.030894388,-0.07826446,0.080504306,0.04225153,-0.028800575,-0.030814618,0.03859065,-0.0927133,-0.033827145,-0.107872605,0.023092777,-0.090109974,0.030489175,-0.014585832,-0.0043832245,0.02814857,-0.01646195,-0.01270559,0.014424537,0.0071852445,0.07437755,0.023553882,-0.09069723,-0.03654867,-0.051130682,0.027015451,-0.014175724,0.017448435,-0.0059872754,0.037978534,0.09429817,-0.016759511,-0.08334954,0.028859796,0.01990773,0.00045596476,-0.01910775,-0.08052106,-0.04995101,0.0044813226,-0.049974963,-0.028710889,-0.048331253,-0.0052526114,0.013384438,-0.06051703,-0.05582647,0.020384118,-0.055196993,0.0011108152,0.0009705269,-0.047615793,-0.021794803,-0.048428386,0.0840858,0.018658541,0.059739385,-0.0610752,0.067310475,0.06815022,-0.06520082,0.06753563,0.0051681893,0.053077374,0.032960966,-0.06899854,-0.10374591,-0.030210657,-0.0063560223,0.04175456,0.022422219,0.055119187,-0.055996284,0.08447413,-0.041066404,0.050796203,0.023695176,0.03733494,0.047317248,0.03276347,0.07788767,0.018037235,-0.061615348,0.053069517,0.0507829,0.07335703,-0.010063686,0.015248441,-0.012049148,-0.023027597,0.02699895,0.019086724,-0.0067861932,0.013425678,-0.02108189,-0.047873568,0.08727191,-0.0005454034,-0.07752503,-0.06983994,0.0487162,-5.614148e-06,0.10718664,0.0743549,0.03176137,0.0032325643,0.01610631,-0.015543144,-0.0062248064,0.02702044,0.10726812,0.06021727,-0.04743134,-0.055661973,0.0014619736,-0.056355275,-0.01805913,-0.012926254,0.05466438,-0.07697378,0.039553214,-0.02339829,-4.850664e-33,0.07089928,-0.06481506,-0.04834434,-0.0677151,0.03170497,-0.012005435,-0.043504268,0.045316245,-0.04200684,-0.012286793,-0.030315427,-0.07202772,-0.04309302,-0.027330305,0.016961979,-0.013298261,0.0020833816,0.051206138,0.07810321,0.018436316,-0.015651736,0.045335602,0.0008853856,0.060262665,0.011918033,0.015353215,-0.024707166,0.040580533,-0.04366453,-0.033024326,0.035836723,-0.03881266,-0.12133658,0.029854875,-0.013346738,0.0053918203,-0.026398813,0.018697063,0.047205403,0.08881857,0.016155468,0.03766466,0.0070953015,-0.0041275555,0.09009013,-0.037279684,-0.00727339,0.11298132,0.0005489511,-0.003805809,0.056230247,-0.0082475515,0.09629715,0.016610216,-0.0381164,0.054592542,-0.008430373,-0.055716,0.044499107,0.06448422,-0.010825582,0.10809885,0.031498015,0.038818024,0.043931387,-0.0035039159,-0.062337387,-0.0024486792,0.033038966,0.065118775,-0.06289742,-0.022180872,0.02288457,-0.012005263,0.086297475,-0.05321552,-0.09453967,0.01930564,-0.016505495,-0.006087479,0.024233146,-0.0047422093,-0.023191625,-0.005474151,-0.04382771,0.03594921,0.010436928,-0.08593124,-0.025009172,0.07942562,0.033303753,-0.012537312,-0.09811363,0.017283022,0.052554067,2.5030565e-33,0.07913134,-0.08931461,-0.01789297,-0.023049304,-0.11016584,0.039190657,0.01748249,0.0036773775,-0.017062059,-0.038446374,0.04399191,0.01684474,0.023924729,-0.07900569,-0.033563532,0.060750764,-0.07874459,0.040246543,-0.029993895,-0.05318909,0.0011770133,0.121370934,-0.01884052,0.058655657,0.032722145,-0.040327854,-0.026721457,0.036491323,0.12744741,-0.046888918,0.10016916,-0.04692947,-0.04639933,-0.01271201,-0.0077693993,0.05129209,-0.03113869,-0.00011281598,0.04668573,-0.05778689,0.011016285,0.06252023,-0.02521572,0.007526894,0.028457196,0.06480541,-0.079274185,-0.030785276,-0.0018092018,-0.038457654,0.045584325,-0.013589601,0.007238725,0.049351636,0.020658927,0.061663784,0.025529483,-0.043283395,-0.04130762,0.04412848,-0.016555866,-0.01669675,0.03742851,-0.0006946225,0.061116375,0.042067003,0.0094972225,0.094219364,0.035622712,-0.05320018,0.15945324,0.051454693,0.025258554,0.042084172,-0.03577727,-0.017613826,-0.044591352,-0.0429246,-0.014261502,-0.07177377,0.017902555,0.012392122,0.0035890234,-0.09790469,-0.060694024,-0.072860256,0.030983964,0.09109001,-0.0103030745,0.08419904,0.05265461,-0.086779095,-0.06960131,-0.003236983,0.062038217,-1.8957394e-08,0.0324594,-0.06749578,-0.013642014,-0.043543674,-0.0068336665,-0.0028811495,0.051169213,0.043733675,0.011114821,-0.0364882,-0.06678576,0.06142067,-0.017482515,0.034854986,0.047049202,0.00042980342,-0.024775563,-0.03155755,-0.01714649,-0.009743952,-0.10792021,-0.020805098,-0.07361342,0.018871743,-0.00079871004,-0.0919104,0.038800832,0.044658147,-0.018892556,-0.0005604708,-0.015237808,0.041093756,0.071274206,-0.034902606,0.0376272,0.016079482,-0.0381457,-0.10378748,-0.024017656,0.046123598,-0.07756283,-0.07470748,-0.01288963,-0.030107997,-0.063178025,-0.0037874833,0.034829713,0.040530737,0.016363135,0.06626731,0.07816274,0.05658042,-0.03063951,-0.06916989,-0.10583251,-0.010205502,-0.011595317,-0.072284326,-0.0015392136,-0.09787087,0.04455614,-0.03877018,0.21956153,-0.046954945 +3.7.1.10,"Highly specific; does not act on other dione derivatives of cyclohexane, cyclopentane or cycloheptane.",384,1.0,0.0031200012,-0.04893166,-0.029336512,0.011063574,0.01950967,0.022537904,-0.022039903,0.043177586,0.10103443,-0.04124405,0.05685915,0.034750625,-0.021002328,0.101402126,-0.007455352,0.0059558493,-0.010155511,0.021802826,0.004096114,0.013205295,0.02151973,0.016134154,0.042900745,0.02130583,-0.055858716,-0.040085066,0.00682651,0.06244873,0.02537691,-0.0028833756,-0.044909604,0.044066057,-0.008985262,-0.051652644,0.019692563,0.08668815,-0.11594483,0.030390587,0.055825226,0.02067859,0.018976936,-0.042211346,-0.029457385,0.018542659,0.041741215,-0.009026408,-0.026813982,-0.0022654634,-0.064458825,-0.001742602,0.052411593,-0.039176226,-0.024567286,0.029310916,0.04428635,-0.021588393,-0.1795574,0.034981564,0.082587905,-0.026430296,-0.016149703,0.021551494,-0.037453003,0.081728674,-0.011142976,0.01248314,-0.0051699663,-0.08146677,-0.010992128,-0.053739995,-0.02825418,-0.08075537,0.017790014,-0.018675787,0.033715572,0.06827482,-0.012568098,-0.03154966,-0.06523456,-0.04532944,0.02906943,0.02283245,0.034765396,0.0032241072,0.06157772,0.08936283,-0.0062024123,-0.022157678,-0.016609319,0.021318696,0.0525262,-0.035396922,0.006186403,-0.06832685,-0.0044394555,-0.016340958,0.06960722,0.035033304,-0.02391847,0.01967052,0.002155509,0.025371965,-0.11849025,-0.028569773,-0.06928553,0.028579406,0.035195503,-0.030672353,-0.057874065,-0.03471482,-0.11241039,-0.060353354,0.09352425,-0.12407098,-0.067506745,0.022082714,0.025514442,0.026220808,0.0074454905,0.03611047,0.021242937,-0.05212564,0.011344179,0.05154002,-0.10983966,0.075404696,-0.017283726,3.958089e-33,-0.016811062,0.010014582,0.04551633,-0.013070147,0.03182283,-0.050383355,-0.0066994885,-0.01899912,-0.09441073,-0.007381639,-0.0194863,0.030874781,0.013879447,-0.073452465,-0.015071317,0.033253923,-0.056032944,0.033884313,0.029683096,-0.017480347,0.032736264,0.058944624,-0.042901453,0.05245005,-0.085526474,-0.011455046,0.058585588,0.024151253,0.027132034,-0.014458343,-0.05661953,-0.053108297,-0.03903664,-0.011512894,0.016567335,0.061598856,-0.11268383,-0.09906859,0.00913861,0.014405039,-0.038532805,0.00074815,0.008776067,0.045655087,0.0422177,-0.057247866,-0.08550016,0.053669482,-0.052130815,0.018421868,0.013092434,0.037976652,-0.015139103,-0.04335448,-0.042663287,0.03533851,-0.016920084,0.022474261,0.011640388,0.0420904,-0.0343861,0.012733049,-0.072165646,-0.117516235,-0.037138868,0.036151726,-0.11783381,-0.013661667,-0.09372019,0.010637469,0.03116935,0.04891662,0.06298734,0.032446425,0.12867863,0.009853978,-0.057573684,-0.03171273,0.10489952,-0.019790934,-0.08173507,-0.031072214,0.021701885,0.03533021,-0.020985238,-0.04679216,0.0040999446,-0.06577766,-0.012159554,0.08137998,0.023401206,-0.077000916,-0.030309765,0.027675766,-0.011548916,-4.5443087e-33,-0.027034827,0.00221027,-0.01240299,-0.031654973,0.027431976,-0.02043945,-0.0111923665,-0.037103478,0.076348595,-0.06197458,0.12773995,-0.0054256567,-0.04227659,-0.018050311,-0.056926828,0.009258502,0.0046132244,0.03784696,-0.05190144,0.053551085,-0.04941439,-0.021754408,0.025180146,0.061851446,0.0182497,0.065485165,-0.0027641302,0.051113334,0.019701784,0.07459092,-0.04948484,0.055133123,-0.04440187,0.049140427,-0.04643161,0.0664077,0.0046584033,-0.035197448,-0.05274437,0.04149527,-0.037767038,-0.039350964,-0.0017275809,0.07897791,0.06883183,0.10079658,0.008867861,0.037691437,0.04579511,-0.019101027,-0.0068656183,0.014597369,-0.03897818,0.09383779,0.05915711,0.12882498,0.01885655,-0.005308069,-0.014666336,-0.04391481,0.09791069,0.020728188,0.012575489,-0.022081977,0.041483782,0.033292867,-0.046297815,0.07423311,-0.0054493975,-0.0092277285,0.061722375,-0.029540077,-0.0007316037,-0.04440419,-0.074783385,-0.06368667,0.09332064,-0.1331821,-0.042083032,0.0033950098,0.011996161,0.048970617,0.002511138,-0.023447206,0.006269959,-0.06155671,0.020489154,0.049499076,-0.03676671,0.027272714,-0.021545198,0.1134979,0.023316178,0.0075644767,0.09278022,-2.780626e-08,0.0013245422,-0.008803033,0.009506402,-0.099796325,-0.030887278,-0.04951382,0.07056725,-0.08072273,-0.059266068,-0.032312896,0.009465462,0.08002377,0.039719652,-0.032221697,0.084461175,-0.0002861206,0.0051686657,0.06019481,-0.031814165,-0.060255338,-0.054418,0.051140867,0.0057130978,-0.06407535,-0.070369534,-0.11248224,0.081830375,-0.018567953,-0.010890611,-0.054480568,0.02982062,0.01603909,0.0101308925,-0.002324113,0.038197793,0.12450249,-0.092100255,0.012056379,-0.025958188,0.013697474,-0.035699133,-0.073091455,-0.038432837,0.07789208,0.07184315,-0.021380447,-0.01856686,0.026530571,0.022075992,0.041958712,0.023993233,0.0022426357,0.006440907,-0.065274514,-0.03464905,-0.008211597,-0.016856767,-0.0021719602,-0.012795073,-0.13179088,-0.03179593,-0.0032774126,0.19842319,-0.025098085 +3.8.1.2,"Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC 3.8.1.9 (R)-2-haloacid dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]",384,1.0,-0.064143546,-0.06635325,-0.0341001,-0.04731404,0.039323848,0.06412852,-0.124553636,0.06200677,0.053637546,-0.017894095,0.04836788,-0.03558594,-0.020936536,0.05284207,-0.04665347,0.04574026,-0.13412087,0.002739176,-0.055662867,-0.089185864,0.01417588,-0.0074859695,-0.045413077,-0.0077355346,-0.049429197,0.03496405,0.048174668,-0.051776417,-0.0603936,-0.09747289,0.021161288,-0.03493718,0.042051606,0.010673337,0.023517156,0.036974788,-0.051184222,-0.08308849,0.06722143,0.06608203,0.10439565,0.045951188,0.027792092,-0.045145813,0.009107137,-0.026344383,-0.02287844,0.0176457,0.011210162,-0.0063592535,-0.0026258235,0.0002494903,-0.054277338,0.05245956,-0.04727166,0.06722556,-0.1120935,0.026670758,0.04627587,0.041889325,0.13466811,0.011867212,0.040816937,0.029173527,-0.007329265,-0.019839985,0.10147025,-0.071856216,-0.023453444,-0.03897165,-0.13645402,-0.037653707,-0.036360458,-0.006945212,0.078031704,-0.017452974,-0.036326233,-0.100501806,-0.021932997,-0.07809163,0.012643518,-0.014823559,-0.009399714,0.049179316,-0.01958794,-0.023352202,-0.033749267,-0.06209483,0.014800903,0.056218345,0.014399495,-0.066152595,-0.058816984,-0.05518951,-0.032538857,0.023618925,0.057703085,0.09085882,0.017662251,-0.018962016,0.0008586418,0.016375758,-0.05566507,-0.047776185,-0.06429504,-0.016523458,0.044102747,0.031049754,-0.053763997,0.012775679,0.054036137,0.017052324,0.08669186,-0.0365559,-0.008448132,0.075857736,0.041565582,-0.049223088,-0.042997397,0.012547848,0.029919622,-0.013003239,0.02953529,0.034484513,-0.011745896,0.094532266,-0.08345885,8.916691e-34,0.08980684,0.021615205,0.08312639,-0.0014318624,-0.029158378,-0.0217767,-0.07636065,0.012198264,-0.108503714,-0.015099749,-0.010229135,0.06300501,0.083734825,-0.011986984,-0.028941255,-0.005999647,0.095302664,0.06835062,-0.04849835,-0.06272698,-0.00082974246,0.09680391,-0.025236625,-0.06531911,0.09314718,0.0051332945,0.0018335358,-0.049985766,0.08044543,-0.026022743,-0.033193406,-0.012562974,-0.060312875,0.06726949,0.09166269,0.05323733,-0.044203743,-0.04256519,0.03983453,-0.002786885,0.009284785,0.0274539,-0.028723389,-0.037490413,-0.04236435,-0.020175142,-0.022258557,0.044812813,0.028801197,0.0669317,0.07129341,-0.035484623,0.077868804,-0.08693908,0.02729949,0.035416447,-0.03404567,-0.04400374,0.030391347,0.060369276,0.009390394,0.020542996,-0.12043744,-0.024677416,0.013683473,0.017865608,-0.12460151,-0.062146083,0.018542506,-0.013120251,-0.09557131,-0.062448245,0.025168492,0.04354261,0.063726865,0.004414987,-0.12415212,-0.008466564,0.00052513776,0.008138669,-0.05968506,0.039650656,0.05137154,-0.033968553,-0.033504277,-0.012683694,0.0078134565,-0.05404853,-0.013182879,0.03551833,-0.029150307,-0.0142353745,0.033900317,0.012868093,0.11760948,-3.1723657e-33,0.05915425,-0.105568744,-0.055762105,-0.049271055,-0.010349958,0.05737503,0.047570094,0.018718585,0.037148796,-0.056003958,0.11340322,0.014371081,-0.0077642635,-0.0383685,0.0053091384,-0.013589225,0.02916052,0.07099546,-0.0026684639,0.0012258416,0.06687061,0.049501847,0.062063757,0.056180347,-0.020444011,-0.00204568,0.019608239,0.06587814,0.041451104,0.04535471,-0.08887162,0.017945053,0.0002443647,0.040107757,-0.09155347,0.023153229,-0.022608597,0.024054557,-0.003059196,-0.013834889,-0.017739428,-0.007809027,0.02686708,0.13782975,0.075175084,0.10877664,0.0038899553,0.022915583,-0.04056307,-0.035486728,-0.07295763,-0.04740242,-0.0057549835,-0.009519711,0.06900452,0.0279835,0.04423698,0.02627103,0.038456503,-0.061560534,-0.07724275,-0.044650074,0.073486514,-0.06477229,-0.006807228,0.04394743,-0.007655003,0.014563576,0.033872943,-0.0953611,0.042987887,0.019728744,-0.0016799539,-0.021671379,-0.05099724,-0.08297217,-0.05199914,-0.07471935,0.03795271,-0.021970462,-0.054787476,0.024695193,0.02161654,-0.045122508,0.0049210796,-0.08823684,0.05474272,0.037008353,-0.027428603,0.061831348,-0.06675737,0.051495,-0.004934216,0.048888013,0.070412196,-4.0945164e-08,0.02649324,-0.003069809,0.072056316,-0.022354426,-0.01071401,0.039068602,0.031534415,0.04123757,0.09292015,-0.06485042,-0.008900422,0.072522916,0.032006152,0.0016577678,0.028983919,0.017391872,-0.041015707,-0.0033809692,-0.031326585,0.03578603,-0.09322861,0.00045750255,-0.07914902,0.022171311,0.019801911,-0.06103353,0.027420804,0.0017677009,-0.03348731,0.009304366,0.019996792,0.047491677,0.08417285,-0.0295366,-0.03467266,-0.07790653,-0.035448242,0.036576513,-0.035632767,0.015412344,0.023887709,0.013446808,-0.09764736,-0.0027924834,0.023150722,0.032786604,0.023583498,0.039816115,-0.0068444903,-0.0018826677,0.04249622,-0.051266234,-0.006497228,-0.050841928,-0.075878546,0.0011970147,0.020470686,-0.07925192,-0.01900331,-0.02645585,-0.008410811,0.016078413,0.114855036,-0.010164857 +3.8.1.5,"Acts on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds.",384,1.0,0.05266632,-0.12402067,-0.042190548,0.017257921,0.043959636,0.08217411,-0.016607981,0.012053021,0.039877474,-0.042016286,-0.037000332,-0.109377466,-0.062382948,0.048329495,-0.026154634,0.046132993,-0.012453619,-0.020506198,-0.06116443,0.052142307,-0.011264012,-0.03637979,-0.034361877,0.05207762,-0.07790536,0.032524362,0.07289503,-0.078288935,0.0104985135,-0.09973928,0.027628854,0.025374936,-0.0023441059,0.025894398,0.019566556,0.0035285319,-0.02252023,-0.037501417,-0.0083811935,0.0012137167,0.0565281,-0.02603736,0.0010637472,-0.098123126,0.033275425,-0.04231735,-0.07495978,-0.015417353,0.028336188,-0.0032622952,0.03542601,-0.070198156,-0.059456117,0.053156573,-0.014015522,0.0099250795,-0.11363802,0.06702104,0.06349661,0.039711077,0.045110516,0.027421724,0.0055489657,-0.016096847,-0.032335263,-0.049200043,0.030421333,-0.024991417,-0.0040929033,-0.011450417,-0.07362046,-0.039292183,-0.017881101,0.048974987,0.031574063,0.011709774,-0.042608734,-0.054451954,-0.03619495,-0.028901938,-0.02460908,0.0077365804,0.11242773,0.019467039,0.041961268,0.06801792,-0.011164374,0.0338991,0.016066223,0.082439594,0.004882056,-0.021748433,0.073043436,-0.05824078,-0.010620287,0.018855387,0.037454363,0.022136707,0.075240076,0.04012057,0.031919315,-0.02894949,-0.07719013,-0.057082843,-0.09230552,0.012333393,0.013061995,-0.07835928,0.018384907,0.0044007525,-0.015982691,-0.049455374,0.029716302,-0.07972988,-0.085861556,-0.008403231,0.049880706,0.027179185,-0.042218864,0.047975205,0.0074749077,-0.021378528,0.055749718,0.048856348,-0.106940374,0.033089515,-0.060887806,3.1154265e-34,0.04981177,-0.012549432,0.10624009,0.042798538,-0.0017238403,-0.09204143,-0.021308348,-0.024925534,0.005298866,-0.06506172,-0.009677761,0.14100842,0.0028213803,-0.023789102,0.03178766,0.026293218,0.04085062,0.017688824,-0.013217519,-0.055454243,-0.10533837,0.09662219,-0.03566776,0.023777198,0.026663257,-0.03815571,-0.050256904,-0.023937717,0.0082043065,0.00028503124,-0.083516955,0.0030152933,-0.025904488,0.08919742,-0.02112457,0.13775626,-0.053166572,-0.06528364,-0.026811713,-0.07065384,0.020158974,-0.0058440906,-0.08840477,0.0017958526,-0.05727182,0.011578415,-0.064408846,0.012303926,-0.028702978,0.0188863,-0.0357153,-0.00081716076,-0.034773428,-0.07175768,0.0014892395,0.042650364,-0.027186101,-0.052610945,0.10575992,0.021582067,-0.0057474435,-0.000583715,-0.026016051,-0.015373935,0.027492037,0.006117463,-0.13392593,0.051912185,-0.014258701,-0.036249876,-0.045398228,0.019624468,0.08854113,0.00021085863,0.09642107,-0.028555335,-0.018889392,-0.022774901,-0.024276461,0.038913157,0.03215784,-0.035450034,0.028048366,-0.06594315,-0.060879767,0.053789735,0.0038737385,-0.045516536,-0.012532538,0.06692049,-0.024794608,-0.0328509,0.06454193,-0.015712155,0.010433289,-3.58196e-33,0.04486513,-0.101249665,-0.08019163,0.037444808,0.056562964,0.095072016,-0.037660804,-0.1292333,0.006742013,-0.016952144,0.05066511,0.040664576,0.038118698,-0.06652635,-0.07370657,0.01540057,0.10546149,0.07640294,-0.010974166,-0.075054355,-0.027012497,0.00045375538,0.008458561,0.11303662,-0.090493694,0.036494426,-0.010641259,-0.05850841,0.07649943,0.09564387,-0.040362343,-0.036432255,0.038815062,-0.029938417,-0.04040715,-0.017008029,-0.0034211613,0.022560174,-0.025334775,0.016207995,-0.07978967,-0.07985512,0.04735874,0.02749632,0.025718585,0.05720368,0.017596915,0.007981577,0.00252853,-0.09016127,0.016916642,-0.014046075,-0.05201781,0.024236651,0.019644773,0.041618273,0.034488354,-0.056161262,0.07775585,-0.0058948244,-0.05013741,0.05509962,0.0067361877,-0.024758521,0.009663326,0.009999855,-0.043798607,-0.008782112,0.0020849823,-0.061972555,0.10397536,-0.02321143,0.08237065,0.06070087,-0.046421245,-0.10667086,0.08474415,-0.11883549,-0.017017782,-0.0524861,-0.00057887466,0.0106038,-0.017749887,-0.012291674,-0.018089011,-0.081059195,0.07082695,0.0022339455,-0.037186425,0.014649462,-0.012700655,0.10993351,0.020771889,0.011860191,0.05930465,-2.7492325e-08,0.051827483,-0.0401841,0.010101362,0.028333606,-0.071422815,0.04838815,0.08699005,0.0071644494,0.012906964,-0.07792205,-0.01957356,0.009521075,0.14967401,0.04133115,0.07990097,0.024433732,-0.0033836097,0.063759804,-0.00028525194,0.0119714,-0.074994296,0.010572927,0.06133828,-0.104876,-0.081354335,-0.06750397,0.022690602,0.07125359,-0.00520408,0.021307325,-0.03012584,0.053389728,-0.012986466,0.0013119815,-0.017654374,0.015304535,0.02017864,-0.012776587,-0.056222647,0.037686594,-0.022208724,0.016426986,-0.06475842,0.025470309,-0.0040584416,0.03837572,0.030758362,0.06495367,-0.0229024,0.028316913,0.03876282,0.044876616,-0.015697774,0.027493166,-0.05492511,0.0347966,0.030318541,-0.062267467,0.011267136,-0.11173457,0.016403735,0.004258449,0.058923062,0.07620632 +3.8.1.6,"Catalyses the first step in the degradation of chlorobenzoate in Pseudomonas. In many microorganisms, this activity comprises three separate enzymes, EC 6.2.1.33 (4-chlorobenzoate---CoA ligase), EC 3.8.1.7 (4-chlorobenzoyl-CoA dehalogenase) and EC 3.1.2.23 (4-hydroxybenzoyl-CoA thioesterase).",384,0.99999994,0.0016698247,-0.042908967,-0.046469733,-0.018065251,0.09426986,0.059251953,-0.060588267,0.04919054,-0.0073705954,-0.04016219,-0.022205096,-0.082033224,-0.041299563,0.095116526,-0.027433036,0.05234079,-0.10630835,0.026700469,-0.005127195,0.021223236,0.03151864,0.0042098034,-0.07687528,0.044491924,0.032106478,0.084806114,0.09328841,-0.04793749,-0.017631179,-0.07149156,-0.06263531,-0.034760423,0.14217293,-0.056962147,0.09289608,0.055587057,-0.017815467,-0.08535332,0.06742192,0.04316763,0.010519122,0.01059698,-0.037111092,-0.09824697,-0.034067202,0.0030519613,0.04483398,0.03384736,0.026939923,-0.082700394,-0.053128395,-0.009924565,-0.033380255,0.045175795,-0.03323304,0.018802546,0.04247504,-0.0019586491,-0.04556049,-0.0017439114,0.019637082,-0.02884862,-0.03064603,0.015026214,-0.0063426015,-0.04453417,0.10293822,-0.021614842,0.034123868,-0.01567364,-0.10964264,-0.049121425,-0.010877188,-0.004458502,0.021181993,-0.033426944,0.032215185,-0.049525127,-0.018617664,-0.053764347,-0.031615864,-0.04507438,0.032987494,0.020453302,0.021668782,-0.066999376,-0.017386356,-0.0570825,0.07781042,0.046482854,0.03034603,0.048434988,0.0064479923,-0.06349904,-0.054624166,0.14485176,-0.029041981,0.033499606,0.098924786,-0.064205736,0.014794643,0.02648887,-0.034477655,-0.072371565,0.046999015,0.0390357,0.019401012,0.12609187,0.05360135,0.013811706,-0.0061984165,-0.012045461,0.07665466,-0.006209166,0.027118756,0.081470765,0.07031341,0.008393601,-0.016416745,0.10437828,0.03690051,-0.07557714,0.06346329,0.032464594,0.007762565,0.06850834,-0.10680183,1.7408825e-33,0.0449457,0.051057544,-0.05376376,-0.04924715,-0.03820829,-0.00089363416,-0.07378862,0.0441004,-0.059567273,-0.08947868,0.046536822,0.0039435937,-0.0018404333,-0.0602343,0.018667877,-0.060102347,-0.0012172505,0.029743925,0.01661496,0.033070594,-0.012412765,0.009846094,-0.05401579,0.036809828,0.02666633,0.038492613,0.08554455,0.038292237,-0.018796008,-0.015242621,0.02317739,-0.018763939,-0.13552774,-0.021208042,0.026358036,-0.01703693,-0.027610287,-0.030530537,-0.0063274642,0.087097846,0.017863614,0.019195274,-0.039347835,-0.052425355,0.053177975,-0.03479215,-0.0552026,0.15727805,0.06307417,0.08166625,-0.015458674,-0.08169788,0.07351865,-0.018052591,-0.032827653,0.024305608,-0.048819263,-0.020709166,0.05291221,-0.0066390918,0.061485473,0.07372669,-0.08011583,0.018449685,-0.032207936,-0.049874432,0.017713234,0.022998936,0.04721141,-0.018478792,-0.13118528,0.027466202,0.028154666,0.048355184,0.04682003,-0.107754715,-0.028699687,-0.038196404,0.053076867,0.03127967,-0.00039220485,0.051296514,0.0585315,-0.018575653,-0.07923875,0.045174725,0.0009948788,-0.04341007,-0.06586552,0.013919756,0.02681563,-0.09305573,-0.036004093,0.04282424,-0.023267286,-1.4095655e-33,0.08275669,-0.08879119,0.016492406,-0.062297028,-0.080499046,-0.0052959076,-0.019166633,0.015013825,-0.006413742,-0.062586315,0.027506305,-0.0042138393,0.0458296,-0.062484793,0.014761357,0.034316927,0.08066794,-0.022789648,-0.025191734,-0.035126552,0.038653098,0.01657589,-0.05139624,0.047005516,0.019986881,0.032448623,-0.016832845,0.066104695,0.10241975,0.07282051,-0.023950383,0.06073048,0.0044888183,0.0242013,-0.05789951,0.028224757,-0.0670417,0.010435141,0.068213195,0.008833261,0.029541817,0.016592756,-0.013756651,0.009369984,-0.018325308,0.079298526,-0.018661153,-0.007700622,0.02220969,-0.07307249,-0.031510722,-0.0059577907,-0.06775419,0.025778433,-0.044757336,-0.011597634,0.02121895,-0.009074818,0.007831971,-0.018138677,-0.033649493,0.0058338325,0.044504892,0.031030687,0.025137272,0.07076499,-0.011589161,0.077869676,0.014903189,-0.012014265,0.055472977,0.030319054,0.00054398616,-0.02405498,-0.06408228,0.00025222864,-0.046752606,-0.0003404751,-0.032525238,-0.008208797,0.047486607,0.017260697,-0.018981934,-0.08532597,-0.0590533,-0.06078305,0.037356853,0.06920907,-0.061372697,0.03907784,-0.042037565,-0.029544117,0.03689363,0.0642907,0.044903904,-3.9320376e-08,0.019148314,-0.06445734,0.07324765,-0.02486105,0.050055884,0.07788709,-0.018204652,0.041812602,0.060463533,-0.031365328,-0.0822671,0.0066388203,0.029008081,0.03063117,0.054056715,0.01842717,-0.04631868,-0.04612654,-0.031138638,-0.009802375,-0.06615031,-0.040255897,-0.10634467,0.0141758025,0.004313443,0.001425384,0.062547475,0.008821478,0.0031064833,0.0075265714,-0.048041165,0.04739781,0.046348665,0.021517897,-0.051758297,-0.014350797,0.032796595,-0.070594326,-0.07897804,0.037334662,0.06568909,-0.041319273,-0.13853304,-0.0059091477,0.05638005,-0.018647205,0.019896902,-0.0041017905,0.008682906,-0.08575419,0.10792982,-0.04597082,-0.030781021,0.01815777,-0.0474937,0.036262788,0.04047465,-0.071904674,-0.039670467,-0.004315802,-0.008145303,0.007615679,0.1757221,-0.028130023 +3.8.1.7,"Specific for dehalogenation at the 4-position. Can dehalogenate substrates bearing fluorine, chlorine, bromine and iodine in the 4-position. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.",384,1.0,-0.02319068,-0.05950158,-0.0076731765,-0.11319646,0.051020727,-0.007506337,-0.0098672025,0.04549407,-0.057927232,0.024623148,0.016897168,-0.059421647,-0.01925557,0.11598633,-0.045144368,0.08488293,-0.069456525,0.017441332,-0.02328617,0.0076321564,0.05777016,-0.03165686,-0.0696694,-0.043364022,-0.011630983,0.04922413,0.05969134,-0.0016197229,0.03832341,-0.106032655,0.031484663,0.044039723,0.057047337,-0.018709276,0.055763077,0.021993456,-0.051954206,-0.053821336,0.07974667,0.08457582,0.009110016,0.09950925,-0.024060274,-0.029832337,0.05356435,0.03417822,0.03746169,0.04794132,-0.0074752965,-0.071163826,-0.0012216135,0.078691065,-0.013875594,0.07264356,-0.0135353245,0.0464317,-0.042833388,0.0029918945,-0.06487876,0.039086044,0.095458135,0.0018539213,0.0060972287,-0.04531932,-0.0010429405,0.022750463,0.07794051,-0.059144698,0.024368942,-0.0066484287,-0.06441495,-0.046057187,0.02157777,-0.038037382,0.040326353,0.008761787,0.038738236,-0.06144944,0.010885439,-0.08263453,0.0059646294,-0.05234867,0.12153077,0.0059359614,0.023153953,-0.047224417,-0.049728874,-0.1310046,0.05477094,0.05603192,-0.025208768,0.022722194,-0.06786938,-0.0351728,-0.05484076,0.06175479,0.0035963277,0.014844295,0.08747329,-0.000981215,-0.00055163715,-0.072166406,-0.12051055,0.05423352,-0.019034434,-0.06383044,0.07597582,0.06582103,-0.05655453,-0.0020028322,-0.0019913423,0.1028663,0.08235287,0.046201795,-0.010580586,0.07429562,0.035872873,-0.068369985,-0.010559197,-0.0009784966,-0.0025001154,0.044410884,0.06096709,0.043518875,-0.02741149,0.0778009,-0.06501296,1.2707076e-33,0.07271352,0.017013632,0.030570714,-0.023004685,-0.036949173,-0.021948684,-0.059993014,0.03477891,-0.07909653,-0.10503136,0.024816776,-0.038065787,0.02728758,-0.0024883943,0.00981688,-0.08524528,0.06496655,0.071899325,0.010230222,0.015087717,0.024927031,0.020157915,-0.07783439,-0.035968214,0.037554067,0.08991573,0.022039576,0.009778934,0.0075499383,0.01717459,-0.047939397,-0.040055826,-0.094051816,-0.041258685,0.0729719,0.012772861,-0.08810156,0.0277115,0.0013663059,0.018471623,0.001871608,0.03922119,-0.015742209,-0.05434351,0.04876758,0.0062355017,-0.052750234,0.09109894,-0.010211494,0.057566233,-0.005423989,-0.021456975,0.037824117,-0.1007133,-0.0006466684,0.021824043,-0.015378192,-0.07640669,0.061044663,-0.008255133,0.003624852,0.022490934,-0.17218648,0.034658253,0.07179891,-0.058845565,0.007961185,-0.060694613,-0.006138682,0.02061644,-0.08054075,-0.09185,0.06113498,0.07248617,0.012973804,-0.038034048,-0.059207425,0.04588353,0.037067164,-0.03490915,0.029543238,0.058997303,0.0005467921,-0.09140809,-0.060441,-0.041272286,0.029821595,-0.071865976,0.043423112,0.024198782,0.046000157,-0.059918832,-0.010177008,-0.017288039,0.016923746,-1.7627138e-33,0.032778874,-0.043533597,-0.013962514,-0.020708187,-0.0832838,0.0908763,0.029456811,-0.012546052,0.07767643,0.018451704,0.048742633,0.043022543,-0.0287093,-0.064527534,-0.05448786,0.042194106,-0.016293991,0.041416626,-0.0055188667,-0.022619525,0.06619053,0.059645083,0.016665908,-0.010139905,0.030637596,0.033357333,0.048732948,0.08060748,0.031428326,0.009355071,-0.07274283,0.031136088,0.053885467,0.009410074,-0.08837436,-0.019126292,-0.07344827,-0.037797265,-0.033518933,-0.0067041507,-0.005239442,0.012717009,0.076702565,0.08875574,-0.016638992,0.055649422,-0.05268521,0.01813569,0.02761745,-0.013353912,-0.026194556,-0.022671571,-0.06383592,-0.02068932,-0.0138477255,0.016142914,0.03735246,0.010424928,-0.010461622,0.027031438,-0.011713959,-0.044743158,0.03925914,-0.042539954,0.04683956,0.057999905,-0.005420473,0.058396466,0.07672136,-0.08184027,0.058513686,0.0044718576,-0.0031164477,-0.00849093,-0.06919058,-0.018001413,-0.10818656,0.0034917123,-0.014015548,0.009506763,-0.08465068,-0.013269385,-0.032765467,-0.026813462,-0.029021934,-0.13170272,-0.0039692107,0.05698948,-0.022130238,-0.029527435,-0.058923826,-0.05793079,-0.023348209,0.043669734,0.03247536,-3.057575e-08,-0.0018249027,-0.03747206,0.042141844,0.042664047,-0.099083625,0.015786793,0.05466816,0.048008867,0.089888945,-0.062344063,-0.04244294,0.1065303,0.024727106,-0.0026275702,0.069474146,0.05382121,-0.03761006,-0.106891915,-0.04610252,-0.012826015,-0.0038148446,0.017221943,-0.05689516,0.013469926,0.0042836014,0.014058048,0.0354653,0.057597682,0.037762757,-0.042223733,0.06209219,0.04968732,0.07299259,-0.05347073,-0.04210756,-0.070946254,-0.0587874,-0.024301752,0.0036416089,0.08307758,0.012610629,0.023307664,-0.07506763,0.049618546,0.039637327,0.050377116,0.004406024,0.0062783514,0.0089617185,-0.052076668,0.001549886,-0.017819427,-0.008343585,0.004778745,-0.13225207,0.066627614,0.04017078,-0.07867219,-0.009620328,-0.016400998,-0.00095834775,0.013589395,0.112869255,-0.023922937 +3.8.1.8,"Involved in the degradation of the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, in bacteria.",384,1.0,-0.03548163,-0.02128786,-0.115598425,-0.015204193,0.08621225,0.06577694,0.06298952,0.11352506,0.02300032,0.0006568769,0.037691783,0.056101386,0.016300656,0.016168788,-0.073537156,0.047496203,-0.029628802,0.029976381,-0.064413026,-0.019974342,-0.006316707,0.0673453,-0.05941583,0.0180527,0.002199062,0.0015779698,-0.018062863,0.035024412,-0.008646681,-0.058760334,0.059046023,0.06773049,0.03846037,-0.048095413,0.09183128,0.025849482,-0.035501,-0.048333235,0.1324458,0.044935443,0.015115078,0.056745805,-0.062043246,-0.00897326,-0.012482195,0.03540676,-0.011668873,0.031670872,0.046657406,-0.048577208,0.020516323,0.006781985,-0.015811859,-0.002896688,-0.05555219,-0.11070998,0.008509711,-0.037530433,-0.10442401,0.05735615,0.031703312,-0.016695475,0.036032904,0.038207248,-0.038253237,-0.015505485,0.08204891,-0.032611225,0.09271055,-0.007701592,-0.05299537,-0.06516742,-0.012787785,0.044099204,-0.025157647,-0.09764235,0.05466297,-0.064756356,-0.03480201,-0.11735439,-0.002472477,-0.08603488,0.029535078,-0.01605658,0.02114256,-0.0810034,-0.05041382,0.024129247,0.120608814,0.01442641,0.05680237,0.063042656,0.0587492,-0.0753879,-0.0604096,0.06012424,-0.040109377,-0.082827434,0.032315243,0.015537944,-0.00785144,0.021310389,-0.12239535,-0.035784457,0.04953175,0.012684966,0.038248386,0.020162217,-0.0057872455,0.0055709975,-0.05408393,-0.048602644,0.014981313,0.02620009,-0.021081936,-0.019177208,0.114150755,-0.0053636264,-0.052771367,-0.017390477,0.0050910837,-0.043237686,-0.029743316,0.03000877,-0.035928667,0.023434747,-0.06426696,-1.9616615e-33,-0.025954489,0.00087847805,-0.06479551,0.01652969,-0.03193949,0.0055469093,-9.296597e-05,-0.05697479,0.0046694092,-0.079900555,-0.049785085,-0.17162213,-0.015454319,-0.024382014,-0.016228229,0.029111998,-0.0062801517,0.03228865,0.042247556,-0.0046428842,-0.07169596,0.08752677,-0.073418126,-0.00785035,0.046845544,0.1022492,-0.0035919256,0.00061098486,-0.010335764,-0.023262238,0.041689023,0.028897865,-0.118812196,0.012999055,0.07077954,-0.004951404,-0.09720228,0.08847946,0.044718757,0.090887524,-0.03194799,0.031227354,-0.024851197,0.023668444,0.07962617,-0.0029666664,-0.059968438,0.15063663,0.051884994,-0.011924074,-0.048251387,-0.03268134,0.060617164,0.016843813,-0.05036108,0.048970703,0.0026260498,0.011134429,0.04443974,0.00046656106,0.05000281,0.032149676,-0.11741439,-0.0055803927,0.055326864,-0.038821373,-0.013922463,0.00724862,0.0429948,0.06474866,-0.08829094,-0.00254745,0.01313998,0.09942474,0.046699088,-0.051557284,-0.058481917,0.0009443463,0.020356786,0.013701758,-0.017468013,0.030263513,0.063026935,0.00066769234,-0.08470955,0.020267306,0.043987107,0.015665768,0.013008032,0.0062820725,0.15529655,-0.079576105,-0.048066996,0.0033763056,0.00028449108,5.0271283e-34,0.014651629,0.04558931,-0.014314166,0.011483137,-0.041207556,0.014205434,-0.031383634,0.023110257,-0.06847494,0.040064678,0.08773096,0.026844198,-0.06463656,-0.034979697,0.060149122,0.030238012,0.055936478,0.01389046,-0.048500832,-0.044420544,-0.008960213,-0.04975263,-0.03210363,0.007767632,-0.06471739,0.04115831,0.016417382,-0.04188178,0.07842935,0.042629153,0.0038258508,-0.049349613,-0.028936503,-0.05999776,0.02804823,0.0064837607,-0.031165965,0.021349438,-0.10064572,-0.050860193,0.037446633,0.021692278,0.055234857,0.003478205,-0.014255848,0.022541603,-0.057783518,-0.021590943,-0.07022562,-0.070029385,0.043393668,-0.037981976,0.021428486,-0.007482904,0.036591362,-0.058965907,0.032533113,-0.02137238,-0.030563638,0.03280947,-0.0047674105,-0.014598039,-0.024117997,0.033306707,0.01910532,0.046128377,-0.018828932,0.088612616,-0.0075448924,0.0008075623,0.017336473,0.06910775,0.003521578,-0.06960647,-0.12106247,-0.03147767,-0.07375149,-0.039429195,0.024718,-0.008861003,0.023658447,-0.025102308,-0.06466202,0.006616634,-0.060814913,-0.042313986,-0.018741429,0.111177325,0.08385149,-0.029812321,-0.029954214,-0.024897613,-0.029433101,0.020159079,0.0020076865,-3.1824246e-08,0.024586089,-0.037112515,0.046230473,-0.018395443,0.030063484,0.0067936773,-0.023711773,0.08976058,0.042145155,-0.007487875,-0.023697508,0.076061435,0.030593012,-0.018609166,0.029741488,0.034623496,-0.0595641,0.017288607,0.031126663,0.023856178,-0.09203791,0.025256211,-0.15464179,-0.054312654,0.036588527,0.030347439,0.03246224,0.049972143,0.085778706,-0.047881808,0.06300738,-0.030949397,0.013789042,0.020623595,-0.054457657,-0.019070005,-0.015310122,-0.093573466,0.017833848,0.04866412,-0.019880898,0.064995416,-0.08455556,0.033658657,0.09919592,-0.0027902378,0.04476117,-0.011362093,-0.06922049,-0.0580048,0.0022860419,0.015742473,0.005525258,0.02334877,-0.049745046,-0.057691302,0.023556875,-0.04293419,-0.019689256,-0.0071794013,-0.020833658,-0.006019275,0.118844636,0.08357333 +3.8.1.9,"Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]",384,1.0,-0.06385699,-0.06554089,-0.029123275,-0.045056287,0.037055008,0.06419535,-0.12509282,0.061430085,0.057948902,-0.016329741,0.05116859,-0.035986412,-0.017618662,0.04518238,-0.051440235,0.048231237,-0.13055086,0.003552399,-0.05050741,-0.089180626,0.01613328,-0.0135337915,-0.04892677,-0.0082096625,-0.05022816,0.034651812,0.043325257,-0.048514053,-0.060103223,-0.09913948,0.016417662,-0.033054806,0.040646404,0.008452904,0.027897961,0.03560297,-0.044713683,-0.0824506,0.058605835,0.06518874,0.1053378,0.04253368,0.024164306,-0.04438413,0.012291978,-0.021833934,-0.020703794,0.01716462,0.008548147,-0.007545269,0.0003475793,-0.0036425507,-0.05502694,0.05191464,-0.05262789,0.071567625,-0.10966664,0.032438856,0.0491504,0.044497002,0.13153777,0.011048417,0.041087046,0.03014055,-0.0005867457,-0.018524375,0.10255745,-0.07277475,-0.029222876,-0.04131551,-0.13677706,-0.041890316,-0.033926025,0.005115119,0.078741655,-0.01898066,-0.038725384,-0.10177557,-0.017051129,-0.08019162,0.011484537,-0.016280042,-0.00998043,0.05164762,-0.017977329,-0.024159223,-0.044170514,-0.06092131,0.01866264,0.058891814,0.0064017028,-0.07470898,-0.061099727,-0.056456123,-0.026468055,0.025526594,0.05704851,0.0949467,0.019183693,-0.021496292,0.0028180706,0.020796942,-0.05569035,-0.05216504,-0.05745232,-0.014283411,0.04620513,0.02855967,-0.055369355,0.015497309,0.053549934,0.01837258,0.09069648,-0.041754395,-0.0040142382,0.07554667,0.045944836,-0.04912075,-0.041086547,0.010665139,0.03296777,-0.014725736,0.024897277,0.03680898,-0.0110223545,0.09657363,-0.078451864,8.671391e-34,0.085597076,0.021214815,0.08641113,0.0055531166,-0.030398274,-0.025268082,-0.07141609,0.009793053,-0.1097234,-0.012607939,-0.014787991,0.059988786,0.08071831,-0.0077716447,-0.027711956,-0.0077588563,0.09913377,0.065347455,-0.04402519,-0.07079625,-0.0011945483,0.09789963,-0.025148671,-0.06957025,0.0995984,0.0047213966,-0.0005556935,-0.050866377,0.07750901,-0.02479743,-0.035639744,-0.0108161345,-0.059892606,0.06300754,0.08892362,0.05397467,-0.042027943,-0.042007092,0.040783767,-0.0006719326,0.009817129,0.02902475,-0.025848676,-0.04027364,-0.041986298,-0.01886717,-0.024284482,0.0425879,0.029673008,0.059795126,0.07296361,-0.039502848,0.07464977,-0.087112226,0.02401808,0.03870376,-0.030323848,-0.051848944,0.025744818,0.06309422,0.0077186762,0.02188741,-0.1197008,-0.023229048,0.014661449,0.017235892,-0.12535264,-0.056692455,0.012058422,-0.017703885,-0.0992085,-0.05566188,0.026864141,0.039832093,0.061838176,0.0026281055,-0.12349048,-0.0055687455,-0.0012936603,0.008354683,-0.05962392,0.03352306,0.04753032,-0.029562272,-0.036169972,-0.013474017,0.00995563,-0.054109946,-0.01442537,0.03341809,-0.032285657,-0.012660708,0.033380967,0.01784522,0.11806695,-3.245708e-33,0.05340647,-0.10462475,-0.050752465,-0.05262803,-0.009360658,0.05985373,0.047616653,0.0207783,0.03343358,-0.052087445,0.11201769,0.013996018,-0.011242941,-0.04570257,-0.0010482329,-0.009857799,0.02222265,0.06964222,-6.535223e-05,-0.0013015344,0.0645201,0.052368406,0.062671006,0.058537193,-0.017073223,-0.0023769492,0.013652096,0.06565062,0.0401801,0.051123206,-0.08798277,0.011713979,0.0036329245,0.0386457,-0.09033085,0.022396576,-0.025520843,0.026771922,-0.002507808,-0.016458996,-0.014720963,-0.008051139,0.029806737,0.13561204,0.07982494,0.11425418,0.004571873,0.020913411,-0.03851327,-0.035383858,-0.07077525,-0.046853807,-0.009969428,-0.002660317,0.07018939,0.029178707,0.04507483,0.025015274,0.031329576,-0.063788645,-0.078730404,-0.045814924,0.07258529,-0.06816151,-0.00039426604,0.045562945,-0.015403914,0.014585136,0.032183424,-0.09747435,0.039745204,0.019270534,-0.00635633,-0.023708748,-0.04907932,-0.08361463,-0.05106969,-0.07164911,0.037258897,-0.02418593,-0.05713979,0.024084276,0.018822093,-0.04627302,0.0042657712,-0.08959106,0.056079578,0.03900536,-0.027318178,0.06070768,-0.07001493,0.051691566,-0.0071107317,0.046298396,0.06391764,-4.1103124e-08,0.023390003,0.0033241357,0.07257306,-0.019947436,-0.016584974,0.039747316,0.025613898,0.049268957,0.096892655,-0.06901831,-0.01560302,0.07595061,0.034884907,0.0004968773,0.03151319,0.017710954,-0.04225789,-0.0031275211,-0.029856779,0.033350676,-0.08861197,0.0016296428,-0.08089812,0.021551704,0.017722396,-0.061181918,0.025394794,0.0022894843,-0.03021479,0.012547509,0.019172996,0.044019666,0.077815406,-0.02806021,-0.030293416,-0.076091014,-0.04325455,0.028630922,-0.031009443,0.017833645,0.024435913,0.011906334,-0.09719153,-0.00039538037,0.026444238,0.032765042,0.030160282,0.04129896,-0.0067997617,0.00538094,0.043119952,-0.055648115,-0.0036040526,-0.050035782,-0.06950901,0.0032948297,0.025692075,-0.08101283,-0.013133202,-0.028555794,-0.00460635,0.015590207,0.116236374,-0.0016800156 +3.8.1.10,"Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]",384,1.0,-0.07452784,-0.08971413,-0.089894585,-0.04703049,0.032307636,0.07791604,-0.1798993,0.051661514,0.0017170707,-0.013634022,0.03516376,-0.113420375,-0.026396628,0.05715241,-0.0368722,0.020190977,-0.0920803,-0.033151466,-0.0056342073,-0.0108352415,0.015587682,0.046984084,-0.08422744,0.0456222,0.0068051745,0.0835843,0.08665609,-0.04386826,-0.03291006,-0.03787573,-0.013623448,-0.053271316,0.054812655,-0.008196089,0.07699323,0.012807858,-0.048573624,-0.03134832,0.124220505,0.04651593,0.030681003,0.03754731,-0.0032523242,-0.06975002,0.011580406,-0.01172514,-0.026681514,0.053929,0.019403737,-0.07825126,-0.03173313,0.015722537,-0.02755416,0.026265142,-0.013339288,0.07874037,-0.007253652,0.01821605,-0.012375087,0.032700468,0.10960692,-0.02162608,0.031844083,0.009620606,-0.03407129,-0.030571645,0.10095991,-0.08652796,0.01939147,-0.022723876,-0.17551082,-0.0058172503,0.023098445,0.008519323,0.03555974,-0.006182697,-0.0065192375,-0.101056196,-0.013157287,-0.098682895,0.024246097,-0.06229317,0.024834234,0.03944187,-0.015958544,-0.08258455,-0.011958733,-0.02046512,0.052626804,0.048737306,0.011419169,-0.014872889,-0.0074616815,-0.06193398,-0.03793794,0.05150053,0.007348355,0.1260886,0.025165947,-0.07457688,0.015875833,-0.016027272,-0.0732455,-0.05699055,-0.040842656,-0.014221528,0.043544725,0.032776553,0.018695371,0.016980715,0.05990849,0.043078326,0.024435379,-0.012235194,-0.02243701,0.106724486,0.07460716,-0.04911949,-0.038632426,0.01016252,0.018844277,-0.045872904,0.07122524,0.016929492,-0.009632297,0.033514775,-0.07898304,9.0036066e-36,0.09870484,0.049889844,0.033897676,-0.035601508,-0.012902787,-0.031837706,-0.096447915,-0.0027863819,-0.086454995,-0.037067223,-0.014205823,0.08602653,0.029695407,-0.025553947,-0.00057727774,0.021729434,0.053669754,0.037307728,-0.051728845,-0.013908146,-0.002639853,0.06819214,-0.017212044,-0.032547347,0.10957965,0.016208377,0.05535996,-0.033102065,0.0508872,-0.013276443,-0.035515178,-0.062428385,-0.050718416,0.051095214,0.09111186,0.00049282087,-0.04349054,-0.035149675,0.036033258,-0.013810928,0.085224494,0.0734271,-0.018623976,-0.038821407,-0.034930594,-0.013029341,-0.030206343,0.057395354,0.0011622888,0.100543514,0.0027073296,-0.034588713,0.055402823,-0.06382128,0.0018857787,-0.034334708,-0.022943344,0.013154761,0.10574541,0.036683906,0.019513475,0.014369695,-0.09089225,-0.0032274048,0.015719863,0.008677301,-0.101689346,0.022124756,0.020187112,-0.03346697,-0.09953762,-0.03066545,0.029601991,0.07267136,0.03055537,-0.072485186,-0.090666115,0.024208318,0.017011177,0.007579667,0.006431332,0.046047945,0.051945318,-0.052516405,-0.043635275,0.04639352,0.00015671432,-0.03771332,-0.027985597,0.029247027,-0.02313845,-0.027861904,0.04752339,0.025381718,0.10242934,-2.2888348e-33,0.07184708,-0.10302612,-0.06032696,-0.04063126,-0.020212831,0.07284569,0.032883566,-0.020115156,0.055595912,-0.07965005,0.092750035,0.07009869,0.04515488,-0.020955516,-0.0040192627,-0.04444948,0.055681545,0.056097012,-0.026043274,-0.05373638,0.11047622,-4.790851e-06,0.008182535,0.029432207,0.027828725,0.004896593,-0.01840337,0.050316546,0.038523678,0.087753735,-0.030060079,0.06583536,-0.017460816,0.018123597,-0.07347149,-0.016229007,-0.06784897,0.03816042,-0.0094402945,0.037931807,-0.028430495,-0.024832422,-0.0016721069,0.081364624,0.020401401,0.08127004,-0.007685717,-0.032469697,-0.022590285,-0.09251233,-0.050718322,-0.021251798,-0.0072300704,0.004652905,0.020066366,0.0046448167,0.010362428,0.06430001,0.032407995,-0.06177736,-0.075577535,-0.04849406,0.01821812,-0.06686106,-0.02892753,0.059384618,0.013180151,-0.0038597437,0.041208804,-0.09119186,0.020286487,0.017699344,-0.035489652,-0.0006789183,-0.09034584,-0.03394626,-0.04293312,-0.03382107,0.059985094,-0.0011055208,0.010565134,0.0053836005,0.02287876,-0.020521715,-0.015293208,-0.097015865,0.06456866,0.043098316,-0.10447622,0.04696312,-0.05457467,0.012023121,-0.017818462,0.011882342,0.08498982,-3.787345e-08,0.0050645787,-0.008905122,0.08165836,0.027153188,0.0021664964,0.054606568,0.049413685,0.023465194,0.073856264,-0.07688937,-0.013282746,0.013002944,0.056142844,0.037193704,-0.002968803,-0.015263974,-0.04567518,-0.0057944986,-0.008011653,0.055318143,-0.051855255,-0.03202022,-0.07436338,-0.04459313,-0.01980221,-0.03249114,0.02678386,-0.01976074,-0.010840177,-0.010664797,-0.020783257,0.014492412,0.08716331,-0.019960197,-0.044370238,-0.09668331,-0.03263072,0.03576145,-0.027221685,0.0013196714,0.07768216,0.0054379147,-0.097923346,0.040746998,0.06566162,0.050470542,0.02589,0.05986454,-0.018356739,-0.051513854,0.09660632,-0.03561072,0.011085477,-0.04097651,-0.08528044,0.019636968,0.02089126,-0.086368345,-0.087263726,0.0016831775,0.0063879513,-0.0024553454,0.09056394,-0.0059824754 +3.8.1.11,"Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)]",384,1.0,-0.07771347,-0.09021355,-0.09993985,-0.033844035,0.022021143,0.057708517,-0.12391262,0.03415925,0.005862965,-0.017435087,0.017042985,-0.10394955,-0.014305922,0.030792342,-0.017358508,0.00223067,-0.06963665,-0.024391824,-0.032610953,-0.059955634,0.0022111502,0.001894961,-0.063306496,0.029911805,-0.009513474,0.082512096,0.07106808,-0.052232124,-0.0423597,-0.06916627,0.006557582,-0.043418836,0.042410526,-0.009101546,0.040896542,0.015891371,-0.08329571,-0.044223905,0.070068665,0.056376368,0.033937104,0.05485619,-0.021715507,-0.041335657,0.018934691,-0.039352257,-0.051382635,0.0591394,-0.006654778,-0.058371186,-0.020910127,0.025323693,-0.04396679,0.014664233,-0.001601495,0.04871763,-0.045556474,0.060772188,-0.03438776,0.04340233,0.11739061,0.018308911,0.05990227,-0.0016315936,-0.052603386,-0.0332626,0.11165152,-0.0703854,0.04172085,-0.016035326,-0.1638701,-0.010076134,0.0065360875,-0.009943871,0.0074489694,0.020751962,0.007145275,-0.099731855,-0.0013453943,-0.07604363,0.03759253,-0.05755701,-0.0013353089,0.05253545,-0.0013172558,-0.044824954,-0.013493137,-0.031447668,0.029081965,0.04516721,0.019668069,-0.0025816737,-0.00556397,-0.027067091,-0.05283193,0.055544663,0.018940337,0.12938082,0.012081935,-0.043698166,-0.01244773,-0.0027455187,-0.06082078,-0.038433887,-0.064087816,-0.044824347,0.022986779,0.017646495,-0.005795674,0.016827561,0.03755876,0.048542634,0.02697663,0.011500008,-0.03889621,0.12226497,0.053751566,-0.031189885,0.019409839,0.008491222,0.018570088,-0.022997105,0.068621725,-0.0031450943,-0.016938554,0.03943887,-0.05605818,1.4006763e-34,0.0750562,0.0453736,0.049452912,0.0073449626,-0.041965958,-0.023583023,-0.10098091,0.03392881,-0.086543694,-0.058790106,-0.037280608,0.102890655,0.038325366,-0.009372561,-0.0056914664,0.016672967,0.08078932,0.04878987,-0.06037327,-0.032887753,-0.0019083306,0.10656927,-0.015340535,-0.045265347,0.09247628,0.011035508,0.053286426,-0.045389675,0.08727795,-0.011955311,-0.046761386,-0.07817581,-0.01782557,0.0629889,0.06578609,0.034190893,-0.06882319,-0.038426813,0.055571593,-0.02209188,0.07907884,0.04034924,-0.019581586,-0.039213333,-0.069416195,-0.00035862168,-0.03844585,0.030969638,-0.008715732,0.06151768,0.00332926,-0.011595228,0.053446013,-0.076965466,0.018074457,-0.015288601,-0.018906731,-0.013603763,0.10438793,0.026132163,-0.010991355,0.0022535601,-0.0822705,-0.028493289,0.04954216,-0.012534469,-0.12763697,0.022721065,-0.030307548,-0.06111859,-0.081839316,-0.066123016,0.0424733,0.05423293,0.0537043,-0.02767162,-0.0733346,0.050721467,0.030052762,0.0017772267,0.01997637,0.06251954,0.03735892,-0.04179271,-0.02334129,0.041171726,-0.017477283,-0.01825772,0.022683533,0.07060971,-0.046322335,-0.0014641467,0.03890535,0.010057549,0.10276304,-2.6215598e-33,0.040306263,-0.08858318,-0.11339184,-0.03376235,0.006433018,0.08119823,0.043157723,-0.079441674,0.08477143,-0.07849611,0.080766894,0.051567934,0.040071737,-0.042926725,-0.04461075,-0.090138145,0.0682677,0.11890953,-0.038561538,-0.024787392,0.09519418,-0.006229437,0.032704357,0.020436183,-0.0075129387,-0.024751164,0.020191833,0.057966508,0.019566126,0.083066195,-0.016495496,0.024941199,0.0068015065,0.042128127,-0.10542983,-0.022117944,-0.041531645,0.012273655,-0.041211635,0.04948608,-0.072807916,-0.0263372,0.023578668,0.09169562,0.07182368,0.09533621,0.003929825,-0.013148626,-0.032933973,-0.035079446,-0.03245923,-0.05858704,-0.039251942,-0.015487061,0.028033629,0.010015097,0.029788489,0.06481674,0.03487065,-0.03339401,-0.06439579,-0.02735483,0.037397407,-0.061475813,-0.05154858,0.059313107,-0.003293862,0.014433172,0.063300975,-0.10743973,0.048668128,0.0006218986,-0.027649546,0.00074042595,-0.051028796,-0.048347324,-0.049442828,-0.011858969,0.06817809,-0.04196369,0.0010698483,0.007652107,0.033415545,0.006268958,-0.03511513,-0.074913725,0.04810688,-0.01172312,-0.074578874,0.031217163,-0.09350153,0.0057277726,-0.057782505,0.04880765,0.10197646,-3.744372e-08,-3.6872373e-06,0.0003737095,0.07541911,0.02817689,0.0017425648,0.03616364,0.053122316,0.03128845,0.08899726,-0.07116415,0.002720973,0.0042076106,0.062361542,0.012154579,-0.010407307,0.0033278526,0.021193225,0.013975959,-0.0048886742,0.057828613,-0.024342952,-0.013085392,-0.041509327,-0.047898244,0.030470677,-0.045928653,0.015511149,-0.033469275,-0.012488478,0.003901367,0.02121928,0.010161129,0.11808866,-0.016070751,-0.016699145,-0.1065546,-0.041741386,0.04861541,-0.0062485044,-0.013739642,0.042876977,0.017794538,-0.06549411,0.047572646,0.050068963,0.033771288,0.041551165,0.084576,-0.034378305,-0.03696357,0.06425911,-0.04829913,-0.0065778703,-0.08449826,-0.084732845,-0.00062915054,0.028713467,-0.10604225,-0.0596895,-0.035178814,0.0069757514,-0.0040348824,0.09977049,0.0036656705 +3.9.1.1,Also acts on N-phospho-arginine and other phosphoamides. Possibly identical with EC 3.1.3.9 (glucose-6-phosphatase) or EC 3.1.3.16 (protein-serine/threonine phosphatase).,384,1.0,-0.0672135,-0.06875467,-0.12708195,-0.056556225,0.061316438,0.010140748,0.06887961,0.024570664,0.0695891,0.013186883,0.026797704,0.031775333,-0.093571976,0.031855315,-0.0007910259,-0.011769402,-0.07214581,-0.023544772,0.03730767,-0.01895072,0.08073294,0.04541944,0.0021357888,0.02722109,-0.016233722,-0.028311145,0.08434547,0.030162523,-0.027650876,-0.07922594,0.0028325068,-0.033223175,0.055340596,-0.028935084,0.017260907,0.08180067,-0.04862132,-0.061530825,-0.032355707,0.023539715,0.11098733,-0.03821439,-0.005967144,-0.032051932,0.029544484,0.00495951,-0.03881134,0.060114913,0.0692948,0.016307598,-0.042643916,-0.07697568,-0.01070933,0.051068336,-0.012737507,0.019376054,-0.20306152,-0.00493142,0.033428393,-0.0074396245,-0.10196681,0.0299517,0.09306704,0.045602307,0.11490123,0.016652428,0.03091916,-0.1500686,-0.03827944,-0.025409685,-0.008138793,-0.09684201,0.054586165,0.0054953257,-0.006868942,0.07805764,-0.048204247,0.008652269,-0.025454344,-0.045284566,-0.022428192,-0.021015171,0.0039960984,0.077319495,-0.0065722787,-0.028654866,-0.0042578136,0.0004601962,0.03501434,-0.0026905609,0.009771185,-0.07083435,0.050299972,0.039506137,-0.040037923,0.0038165092,-0.049536362,0.0767504,0.03595628,-0.019594403,-0.019561844,0.11038317,-0.026341194,-0.014580808,-0.013528374,0.06813194,0.042649183,0.040105786,-0.06568158,-0.0024918825,-0.033029046,-0.039724886,0.04485026,0.004189324,-0.0494352,0.039330088,0.0095983455,-0.07595955,-0.042265575,-0.0023366003,0.04523387,-0.061034843,0.02613122,0.027059374,-0.025623227,0.14329074,-0.1225724,8.660094e-34,0.032810528,-0.013886358,0.06669353,-0.0750394,0.050052635,0.009995134,-0.09052208,-0.0023069705,0.0031536524,-0.08620343,-0.06563098,-0.014872644,0.1263695,0.024204176,-0.041108828,-0.054173335,-0.021051979,0.087057136,0.047547884,-0.038222983,0.022253923,0.08822883,-0.004636184,0.03188184,-0.005788698,0.041105155,-0.06499645,0.020747134,0.023683554,-0.01757127,0.018719357,-0.01924652,-0.03935395,-0.018569492,-0.011673107,0.05203748,-0.06436547,-0.037053943,-0.007692633,0.08765022,-0.015254951,0.010188061,-0.02062465,-0.031243984,0.0017386233,-0.09512402,-0.095859356,0.08069444,0.08468127,0.0408437,0.011508847,-0.08253813,0.0828663,-0.038927812,0.03374514,-0.024839433,-0.068666734,-0.031520057,0.054046135,0.047366377,0.011667007,0.038648568,-0.037407987,0.011553848,-0.05644039,0.053862553,-0.066486254,-0.0570538,-0.071681306,0.027488852,-0.038067915,-0.0074110455,0.06581382,0.020215405,0.012602373,-0.04205806,-0.086234115,-0.0037718234,-0.0621447,0.027507462,0.01354815,-0.050820082,0.0307937,0.035907604,-0.07471153,-0.0017305295,0.014325953,-0.043230053,0.0042886576,-0.016910134,0.076661736,-0.05657465,-0.08424129,0.018576061,-0.027642516,-2.3253868e-33,0.026518734,-0.057271283,0.067817144,-0.051134083,-0.016969621,0.039269485,0.084957235,-0.014202771,0.06689484,-0.041615102,0.07865257,-0.037097476,0.021257438,-0.100207455,0.006502798,0.012594886,-0.016944353,0.011975739,0.013936353,-0.030230034,0.0041268305,0.018988881,-0.023636192,0.042865478,0.047472622,0.021837499,0.0010474569,0.07548194,0.003007307,0.008669779,-0.0772127,-0.002885823,-0.05520306,-0.029549077,0.024105445,0.05062626,-0.01810681,-0.013787539,-0.0037723663,-0.11370295,0.039486043,0.04680925,0.11563562,0.029813187,0.06880474,0.11105913,0.012014549,0.03367282,-0.063021876,-0.022120116,-0.016348066,0.006154835,0.0018863135,0.06654297,0.021640081,0.04540333,0.0057400977,0.044340968,-0.04541977,0.0067225476,0.046480197,-0.06462463,0.033675823,-0.01109594,0.06360158,-0.01637508,-0.04325227,-0.0022242866,0.05624683,0.058102313,0.040311705,-0.016016003,0.02350962,0.007944575,-0.034056265,-0.04249218,-0.068951756,-0.011634595,0.0041784635,-0.056448594,-0.007853668,-0.013033881,0.007721082,0.01838515,-0.013320404,0.050571732,0.035995282,0.036732666,-0.0067219106,0.051092826,-0.056793433,-0.01872499,-0.09364319,0.036658827,0.028078202,-3.6973844e-08,0.11342954,-0.06963689,0.025484923,-0.03692771,0.027390653,-0.01617471,0.02265605,0.060977243,0.0084925275,-0.021147497,0.049701277,0.068781875,0.07326404,-0.068960235,0.08328689,0.003672956,-0.03911372,0.064515755,-0.019114919,-0.036361553,-0.04269399,-0.010163897,-0.055273168,0.028971082,0.024835648,0.0070568873,0.048106123,0.006724673,-0.0763867,-0.060927,0.021195862,-0.016033491,0.042792574,-0.06784066,0.0007187035,0.026180375,-0.0737998,-0.030856749,-0.002819862,0.03863926,-0.05578566,0.0062597287,-0.040218685,0.02066931,0.046328697,0.04985284,0.014360542,-0.012640331,-0.0691781,-0.06286142,-0.014856599,-0.032371994,-0.010876733,-0.08318302,-0.09072678,-0.057969112,-0.04352004,-0.074167,0.08625064,-0.018476306,0.049594365,0.02380529,0.17799595,0.025217474 +3.10.1.2,Also readily hydrolyses aliphatic sulfamates with 3 to 8 carbons.,384,1.0,-0.02425773,-0.08302879,-0.06432834,0.048262604,0.02336032,0.053453013,-0.014644611,0.025076866,0.01815,-0.026722798,-0.0006806406,0.010591659,-0.062151466,0.03962151,-0.017091313,0.025128936,0.012317445,0.040570352,-0.019759247,-0.008015298,-0.007187011,-0.041422762,-0.016656233,0.026829213,0.027056145,0.14061838,0.0042137685,0.0022418315,0.022970615,-0.09423794,0.04044767,-0.02342138,0.002337564,-0.07101506,0.028926611,0.062072214,-0.040172476,-0.020451587,0.00901563,-0.03408074,0.012072209,0.005910372,0.045013733,-0.06965844,0.03652605,-0.07168704,-0.0036910402,0.051756795,0.082792304,-0.081256054,-0.011610721,0.00078230473,-0.07543394,0.035873573,-0.029612994,-0.032274403,-0.08490239,0.005717531,0.010641335,-0.0123663815,-0.032822024,0.052746728,0.0061149662,-0.014768884,-0.042171273,-0.031773385,0.0073629785,-0.06230028,-0.0029807885,0.13220532,-0.10313261,-0.011369385,-0.036499534,0.07352363,-0.048551854,0.07383472,0.03737991,-0.112074435,0.07271371,0.012373216,-0.066449,0.04071533,0.009904646,0.110714704,0.0032256017,-0.017858751,-0.0022492788,-0.02979762,0.0005941221,-0.02525271,-0.03310135,0.02837392,0.04259288,-0.021999529,-0.0045787655,0.037727866,0.028123302,0.10292463,0.007626223,-0.021151202,0.01553429,0.02225023,-0.07819761,-0.13319622,-0.056232665,0.047637954,0.032378457,0.07405141,0.044234596,-0.005748783,-0.07191102,-0.020998104,-0.0074895783,-0.047631927,-0.059555445,0.096639305,0.07674815,-0.05210449,-0.06373065,-0.02420711,-0.016760223,-0.031030519,0.029029123,0.00393903,-0.04379651,-0.025374424,-0.05298381,-2.3982367e-34,0.076233916,0.036168333,0.082761236,0.004068433,-0.05820217,-0.01085905,-0.14273235,0.011905891,-0.015804421,0.011634209,-0.026137337,0.01246987,0.022342524,0.014774609,-0.0048212204,-0.072029814,-0.027533447,-0.032304473,0.02786999,-0.09952889,-0.045521345,0.016725963,-0.0065616267,0.018978948,0.038345404,-0.042377654,0.07952255,-0.033133794,0.048120584,-0.0470875,0.08266942,0.022440333,-0.074684165,0.03377356,-0.024250668,0.028853003,-0.07485829,-0.018725032,0.038057055,-0.003493837,0.052562613,0.04907736,0.06047563,-0.09344074,-0.0017412489,-0.045520984,-0.07660237,0.034582168,0.105823725,0.010179392,0.031995066,0.015497546,-0.0050031273,0.0822298,-0.026745683,0.008155573,0.0418641,-0.005088763,0.031038553,0.023988232,-0.056264948,0.027485758,-0.047521837,-0.05643918,-0.055306245,0.06693745,-0.030412827,0.09050961,0.01345298,-0.045097306,-0.10215625,-0.023477934,0.024511378,0.010021755,-0.04043596,-0.010425808,0.040823273,-0.01611055,0.060497038,0.08562347,-0.0029758331,-0.09202684,-0.03161898,0.048892125,-0.10900398,0.010882558,-0.019290503,0.055062827,-0.0021716321,0.024075685,-0.008481,-0.06078018,-0.010676303,-0.016983591,-0.07758014,-2.8249745e-33,0.060520854,-0.07004636,0.015578934,-0.01634954,0.0040446515,-0.054365244,0.07766974,-0.064654835,0.053159744,-0.009856221,-0.00216053,0.0486939,0.131913,-0.031239564,-0.014321173,0.08875724,0.021383163,0.03788164,0.05667362,-0.042631004,0.033565387,0.08929047,-0.067231916,0.014770341,0.040326204,-0.00021621598,0.015583421,-0.054820266,0.07452062,0.06430162,-0.0077732285,0.007930805,-0.043026753,-0.06391084,-0.021293063,-0.019412417,-0.006122382,0.023297008,-0.062746055,-0.00929392,-0.035768803,-0.06704346,0.022572048,0.10925146,0.057781942,0.07624583,-0.024113938,-0.041339446,-0.060949154,0.0579511,0.069148585,-0.006569567,-0.065719604,0.03406954,0.009565805,-0.005959316,-0.022302227,0.0057779835,-0.0030229439,-0.020649469,-0.027337879,0.017188348,0.0014701745,-0.1517528,-0.04801698,0.079179324,-0.07199185,-0.047227804,0.0064467727,-0.05422234,0.070685916,-0.04826861,0.033811536,-0.012573756,0.052598435,-0.06195179,-0.009206083,0.034035258,-0.01645654,0.006641886,0.019704748,0.050903782,-0.0004718193,-0.08083749,0.05497118,-0.016951585,-0.042671494,0.040591452,0.009907314,0.05650898,-0.03220003,-0.021338865,0.056810394,0.08903184,-0.039154284,-2.049965e-08,-0.077362895,-0.010320536,0.08751958,0.032072097,-0.10106162,0.07202148,0.11917184,0.04374986,-0.02693664,-0.04879301,0.01525779,0.05513907,0.039923657,0.036746904,0.029251903,-0.015359191,-0.08480149,-0.02640278,-0.0054127346,-0.05693508,-0.04901662,-0.007566956,-0.025222242,0.046450388,0.0014027386,-0.03129176,0.04230114,-0.08212027,-0.054115407,0.010226061,0.025452394,0.07934283,0.005687962,-0.08569274,0.072547115,0.04001754,-0.048536863,-0.03148926,-0.04653948,-0.015120493,0.0035232096,0.026308086,-0.035974793,0.008524653,0.027975637,-0.027006738,-0.046826668,0.08656762,0.002248509,0.023060517,0.10132532,-0.024569314,-0.018559095,-0.09122259,-0.047279954,0.02472816,0.06637585,-0.103938006,0.03177757,-0.01767578,0.06556774,-0.08674317,0.16090953,-0.008702462 +3.11.1.1,"This enzyme destabilizes the C-P bond, by forming an imine between one of its lysine residues and the carbonyl group of the substrate, thus allowing this, normally stable, bond to be broken. The mechanism is similar to that used by EC 4.1.2.13, fructose-bisphosphate aldolase, to break a C-C bond. Belongs to the haloacetate dehalogenase family.",384,0.99999994,-0.07714267,-0.008100115,-0.060156036,-0.012200059,0.04411028,0.020020837,-0.052626573,0.06794068,0.026250044,0.029031163,-0.0013735882,-0.027841922,-0.08641254,0.078200966,-0.086249605,0.053016923,-0.07286815,-0.01879724,-0.0115184905,-0.016742732,0.021471871,-0.006010458,-0.013657072,0.032243036,0.009503445,0.071174815,0.062230464,-0.042181373,-0.019034993,-0.07364748,-0.0101626245,-0.09064155,0.07795588,0.026066128,0.06012975,0.12426597,-0.08954482,-0.06622528,0.018147072,0.011268695,0.022423174,0.016187785,0.0010335804,-0.034411047,0.06827575,0.010241279,-0.05904543,0.10050678,0.034084603,0.022368532,-0.040263195,0.002864901,-0.052495643,0.03671508,0.008495908,0.0518707,-0.06831712,0.060804423,-0.009063992,0.066643804,0.09279862,0.07312221,-0.0058812825,0.04652348,0.054107845,-0.045073617,0.09216815,-0.06879063,0.037991926,-0.049819395,-0.07785347,-0.09894765,-0.047446158,-0.036210615,0.07948134,0.0075890506,-0.06528753,-0.06323305,0.030433727,0.00635475,0.035055853,-0.01495077,0.03367017,0.010587167,0.09418602,-0.021924425,0.03884904,-0.08049321,0.07096566,-0.020108271,0.007857135,0.012741944,-0.053045068,0.010592865,-0.055401973,0.005868724,0.00021882747,0.033650868,-0.040967546,0.014080396,0.013281047,0.07203261,-0.048174553,-0.055801373,-0.0767217,-0.04364822,-0.0066934717,0.05315107,0.018307017,-0.0064176135,-0.05436677,0.033930205,0.014937939,-0.03181877,0.0022113724,0.09343167,0.007872565,0.012619991,0.036104523,-0.012056091,0.0038466384,-0.031495057,-0.028428754,0.0655248,-0.07110524,0.048189502,-0.115921974,-1.6207222e-33,0.0786666,0.037457883,0.03667948,-0.03452565,-0.027550235,-0.023619987,-0.0948897,0.0673695,-0.15560393,-0.077325165,0.024241546,-0.061400164,0.105962366,-0.010105874,0.016051441,-0.057076875,-0.012477584,0.009081121,0.052574325,-0.00980599,-0.021256845,0.08066645,0.016117461,0.025521705,0.051350508,0.053256016,-0.0057297824,0.09740118,0.054307707,-0.0011994918,-0.02406113,0.004897941,-0.09034807,-0.031202426,0.0028241822,-0.021783743,-0.07478365,-0.036376573,-0.02205467,0.035829067,-0.038409784,0.006083596,-0.009591951,-0.078752354,0.027180286,-0.07517579,-0.060492173,0.09202285,0.0119422665,0.012647794,0.08915495,-0.060947035,0.025410857,-0.00035951787,-0.08720367,0.054059118,-0.0046373927,-0.06543448,0.010423313,-0.0018683827,0.073610984,-0.0071817245,-0.038022276,0.052900206,-0.010013295,8.40283e-05,-0.08941373,0.038109142,-0.015172161,0.04650288,-0.13491249,-0.0159723,0.0126816165,-0.036703262,-0.015801167,-0.029590212,-0.08719943,0.074915744,-0.013797387,0.005442767,0.03737607,-0.013020965,0.10245445,-0.04102697,-0.02418035,-0.043481622,-0.022195268,-0.07566431,0.016775373,0.03771958,-0.0021842816,-0.0708617,-0.027522998,0.04686093,0.081309564,-9.852982e-34,0.11419546,-0.11484879,-0.008066933,-0.041041218,-0.039316982,0.005079254,0.0150265135,-0.06412587,0.029199174,-0.072093084,0.08651788,-0.028201578,0.053528927,-0.037641592,0.020158622,-0.03509357,-0.016674012,0.0809247,-0.026206302,0.05790756,0.06772266,0.024093598,-0.0011394483,0.014199493,-0.0043352344,0.0077567883,-0.02171302,0.009592085,0.10677639,0.012545848,-0.105539106,-0.012226451,-0.035688564,-0.00899362,-0.052355755,0.08647152,-0.103006795,0.010893538,0.026557283,0.003967051,0.02245085,0.045519065,-0.0071045305,0.049194552,0.08040558,0.066470414,0.039402332,0.008396755,-0.046602786,-0.025889272,0.025449287,-0.022406563,-0.006839443,0.018302964,0.026010334,0.033274557,0.013822577,0.0146677,-0.05802063,-0.029562596,-0.05640611,-0.01312661,0.039927855,0.01662051,0.06816618,-0.015554686,-0.06603627,0.038248986,0.045198664,-0.034604184,0.11641166,0.060468663,0.015602134,0.044043556,-0.06937966,-0.04473319,-0.09931766,-0.045935843,-0.02256863,-0.006492442,-0.021277683,-0.023912445,0.031375702,-0.05606393,-0.02301747,-0.10675484,0.022708846,0.027890036,-0.01162011,-0.0091541335,-0.035439312,0.02045544,-0.0015522012,0.05554382,0.07825751,-3.6446394e-08,0.03397831,-0.025640953,-0.019959295,-0.0036781395,0.037122313,0.016612409,0.06381513,-0.030859986,0.032140784,-0.057059478,-0.058990434,0.08870702,0.019547649,-0.003062907,-0.024588238,0.001795252,-0.056399953,0.011140766,0.005607778,-0.015769862,-0.111172594,-0.053724695,-0.022534272,0.031933133,-0.021559674,-0.05730432,0.030164639,0.07043198,-0.05514847,0.016343713,0.011853464,0.0015333984,0.09797969,-0.024130227,-0.0143833645,0.044999693,-0.059810918,0.013635767,0.008791757,0.033723976,0.06039901,0.024669755,-0.07864545,0.028300975,0.041912347,0.05563928,0.03456133,0.03741269,-0.05799931,0.07709181,0.042077396,0.024554197,-0.07785895,-0.06062866,-0.04663333,0.008315669,0.019022088,-0.028590923,0.048101958,-0.077270396,-0.02518169,-0.04467404,0.1805161,-0.0069666817 +3.11.1.2,A zinc-dependent enzyme. Belongs to the alkaline phosphatase superfamily of zinc-dependent hydrolases.,384,1.0,-0.11297142,0.03450436,-0.03803812,-0.0055372063,0.05017434,-0.018699165,-0.027523246,-0.028506739,-0.055467196,-0.014184299,-0.039687466,-0.011513071,0.029933589,0.040575057,-0.063435845,-0.00012457912,-0.08127662,-0.023876999,-0.038237996,0.0029206118,0.09726622,0.022278402,-0.016047094,0.027498187,0.05574852,-0.06365989,0.06567244,0.006519085,-0.06617684,0.018827489,-0.07020981,-0.037644297,0.04732978,-0.008541179,0.014436431,0.039953023,-0.01183528,0.018129641,-0.070739,3.0570765e-05,0.061215132,0.11319101,0.03010439,-0.05328478,-0.05286203,0.04006847,0.027223427,-0.028759886,-0.0072706887,0.023691937,-0.11096743,-0.08723066,-7.093191e-05,0.053741902,-0.010572155,0.0504122,-0.077226974,0.049204733,-0.015051696,-0.021777252,-0.040389314,-0.08165717,0.01653712,0.04474526,0.04806753,0.0057587307,-0.018363316,-0.02835332,-0.077095404,-0.07207047,-0.055178914,-0.046488956,-0.008498445,-0.005106881,-0.04543316,0.04912763,0.089875355,-0.048396237,0.014262638,-0.01566603,0.030805292,-0.014276773,-0.0034504102,0.08622028,0.026617968,0.019850753,-0.07515404,0.011531936,0.031203754,0.018478647,0.011111439,-0.011180399,0.0360377,0.020203702,-0.05665512,0.07660241,0.035858557,0.047809295,0.004214206,-0.024892485,0.04416705,0.043739878,0.08011476,-0.07459569,-0.006498187,0.07382051,0.04797138,0.059306033,-0.037572905,0.03190874,0.03222451,-0.008727329,0.04825786,0.005490579,0.009306343,-0.024017224,-0.03648815,-0.041347444,-0.07866401,-0.056731887,0.010329075,-0.017809836,0.010919858,0.0062480993,-0.017986119,0.07297105,-0.15109974,-2.5544363e-33,-0.03759056,0.027396007,-0.030901637,-0.047856968,0.032935437,-0.0031347298,0.00806921,0.06336913,-0.07241515,-0.07487265,-0.014715584,-0.020044642,-0.0062139505,-0.06608053,-0.037220754,-0.05206997,0.021585872,0.035117574,0.014188929,0.08126654,0.031547643,0.0015208035,-0.08784379,0.0053136777,0.0057091694,0.042997863,-0.041855127,-0.072107084,-0.013394498,-0.02533367,0.047462117,-0.013777296,-0.10013868,-0.05646298,0.13490348,-0.028490884,-0.027421087,0.009373238,-0.017841883,-0.0766953,-0.03480634,-0.045464575,-0.059316177,0.052194472,0.013435486,-0.06880085,-0.096688375,0.08391505,0.07804941,0.0011885565,0.011482229,0.041479997,0.045561656,-0.005560731,-0.077891394,0.029305672,-0.048777,0.014742648,0.042510577,0.03726145,0.0052440516,0.08715611,-0.08566734,0.10173625,-0.012789803,-0.011082253,-0.053275328,-0.0643213,-0.019193921,0.13988838,0.02913793,-0.04407679,0.071161374,0.035183452,0.0074950135,-0.070926905,0.028082935,-0.035613492,0.010317416,0.032363966,0.021554558,-0.042070847,0.0021900523,0.024097173,-0.0685096,-0.06377578,0.023678226,0.007582391,-0.038578693,0.004279512,0.03233876,-0.049363267,-0.023065004,0.010789436,-0.031927444,2.8904242e-34,0.1061556,-0.021588102,0.059564143,-0.09224439,0.0141954115,0.010566763,0.087318905,-0.056267854,0.016971221,-0.027764345,0.058724385,0.01941053,0.0196478,-0.0070731537,0.03527112,0.017644258,-0.04832345,0.07908938,0.08774902,-0.03579334,0.028125472,0.10498912,-0.017401384,0.05957106,0.029096005,-0.032219693,-0.015464355,0.13285331,-0.0052409847,0.0657807,-0.0695348,0.05914873,0.00017833518,-0.08928965,-0.06275778,0.058651883,-0.090766065,-0.039588563,0.007044901,0.03980775,0.0056403736,-0.04689632,0.016417189,0.039369952,0.0739846,0.07036006,-0.04870335,0.09475247,-0.042974137,0.01748031,0.023627179,0.10236519,-0.029236753,0.015608359,0.055847168,0.054392256,0.0009769205,0.04901255,-0.021466099,-0.07875208,-0.005243922,-0.059328664,0.025050046,0.08589621,-0.029988099,0.030856267,0.047900062,0.0009360915,0.007959793,0.023715353,0.023831265,0.04456749,0.045557402,0.011677687,0.0059647895,-0.00013343571,-0.07322269,0.028100831,-0.029874546,-0.005669689,0.039439514,0.07117823,0.08341086,0.038859766,0.011855698,-0.057252657,0.0075886333,0.028833304,-0.045614474,0.02542894,-0.032046806,-0.1223357,-0.08618342,0.020643294,-0.037259243,-2.1248127e-08,0.019940495,-0.029877193,0.04722436,-0.08941406,-0.015259885,-0.033353668,-0.010426701,-0.041326128,0.032674517,-0.026657946,0.075975776,0.006294152,0.039941564,0.045068122,0.02529006,-0.0016945304,-0.034244247,0.008688824,-0.047204413,0.075042576,0.017522808,0.025232956,-0.12866655,0.086972624,-0.0050185365,0.022776445,-0.020735594,0.039527964,-0.06960386,-0.02520344,0.016239498,-0.009449019,0.060660418,-0.047168616,-0.042454712,-0.006194563,-0.0003845804,-0.046003547,-0.0383225,0.009498275,-0.07180057,-0.051725946,0.07185787,0.031198919,-0.044701148,-0.04439171,0.00847937,-0.015776314,0.09859264,0.026208268,0.018356187,-0.0422388,-0.04888212,-0.103581816,0.015505306,-0.07443068,0.020138528,-0.06081158,-0.077984296,-0.0007763961,0.09228949,0.063938655,0.19432099,-0.06989612 +3.13.1.1,"Requires NAD+, which appears to oxidize UDP-alpha-D-glucose to UDP-4-dehydroglucose, which dehydrates to UDP-4-dehydro-6-deoxygluc-5-enose, to which sulfite is added. The reaction is completed when the substrate is rehydrogenated at C-4. The enzyme from Arabidopsis thaliana is specific for UDP-Glc and sulfite.",384,1.0,-0.08836092,-0.017572343,-0.038812336,-0.031188887,0.029466875,0.046993528,-0.05250228,0.02441328,0.012506846,0.03904372,0.03151956,0.03157258,-0.15336359,0.008440338,-0.074308194,0.032718025,-0.033028543,0.062357746,-0.011858598,-0.100756876,0.07853956,-0.0048437533,-0.021569056,-0.04375258,0.10630605,-0.0028010316,0.0035565181,-0.022745771,-0.03776288,-0.073554546,-0.04916348,-0.007659648,0.0092335865,-0.01358408,0.0068481034,0.14507149,-0.028157216,-0.091964856,0.0065439534,-0.06194632,0.053477723,-0.004024368,-0.0696724,0.06448948,-0.07163887,-0.058709007,-0.03471627,0.08675746,0.02858469,-0.05545933,-0.008679426,0.015925037,-0.063692465,-0.021220569,0.028868528,0.0010988218,0.023162402,0.02386601,0.026554758,-0.041767906,0.004350268,-0.020362657,-0.0077189477,-0.017249627,0.047532875,-0.012288887,0.08542091,-0.052471936,-0.02042931,-0.008606678,-0.09310017,-0.004174968,-0.037942566,0.012325223,-0.038656898,0.077889666,-0.06632358,-0.036950532,0.060734205,-0.0012284918,0.09379617,0.05748166,0.0074160667,0.04936226,0.023008544,-0.028528512,-0.030994473,-0.002973983,0.008935142,-0.021631222,-0.016230876,0.02367817,-0.09624388,0.041547973,-0.09887786,0.100805886,0.01109219,0.018790849,0.0018802158,-0.048875134,0.014622656,0.10030423,-0.04740287,-0.09748514,-0.00086666964,-0.0048299707,-0.020845685,0.08322708,-0.10307779,0.039683666,-0.026514757,0.0020156186,0.01668662,0.009835572,-0.022499349,0.08833827,-0.016039696,-0.021349235,-0.09952603,-0.06777109,-0.016252583,0.020697145,0.010883849,-0.022989186,-0.039386142,0.012757172,-0.095658615,2.89819e-33,0.11427046,0.031971563,0.0035976802,0.020303762,-0.029209694,-0.018656591,-0.06623304,0.10777724,-0.04667263,0.032353144,-0.0703156,-0.08498625,0.015692089,0.023292392,-0.066809855,-0.0018970815,-0.008187857,-0.038475465,0.038329303,0.017079346,-0.016721768,0.06510036,-0.021746576,-0.008781503,0.018986436,0.036026794,-0.025276465,0.009300794,0.03906095,-0.03557808,0.02806681,-0.096840285,-0.061389226,0.0066021397,0.104417235,-0.04843329,-0.06440822,-0.021051494,-0.008613586,0.039627414,-0.033638366,0.06726525,0.030503165,-0.05087878,0.06456618,0.047658905,-0.037642933,0.041069996,0.041697446,0.09576291,0.065301016,0.011925651,0.07587629,-0.032047726,-0.0005566612,-0.0035532108,0.009464965,-0.028155513,-0.011963942,0.054990184,0.019193424,0.0537942,-0.049880076,0.002258044,-0.02039106,0.020280227,-0.12018645,-0.040676244,0.019374667,0.021688236,-0.007438424,-0.04204588,0.042873293,0.03948405,-0.0012630194,-0.03203287,0.016850147,0.041055273,0.00034524355,-0.045563735,-0.04394412,-0.028700313,-0.028347507,-0.0017311522,-0.049438287,-0.020843897,-0.043748997,0.017006451,0.0235867,0.020247726,-0.003429787,-0.017174192,-0.049773365,-0.024268765,0.0925457,-4.8260622e-33,0.110966675,-0.00060412544,0.017631417,-0.0770648,-0.032969773,0.026413709,0.066695906,-0.095180035,0.069603585,0.023796678,0.033807192,0.044459045,0.02102451,-0.007948434,0.036487084,0.06014464,-0.056859665,0.026405545,-0.07390455,0.010187547,-0.007639091,0.19280474,0.05887028,0.039574854,0.12612101,-0.037685066,0.0775034,0.045660406,0.017728709,0.0007766644,0.05744387,-0.020644534,-0.036404528,-0.03274631,-0.0038930818,0.0071134833,-0.009050139,0.012646532,-0.04265759,0.032627825,-0.005756987,0.024469353,-0.033031143,0.077009395,0.07151242,-0.023330178,-0.07454128,-0.017147683,-0.011287302,0.013621096,0.06512171,0.0069225277,-0.052730866,0.009269436,0.030908264,0.05121565,0.06527729,-0.0024847442,-0.024362464,0.008010046,-0.013249555,-0.080964185,0.053479087,-0.071789205,0.015623604,0.034706168,0.014125856,-0.034875657,0.013293801,0.02466903,0.026339065,-0.0037648908,-0.053345125,0.013978689,-0.013870887,-0.015023625,-0.0822807,0.040619113,-0.045384586,-0.01361522,-0.032490604,0.032074098,-0.038618088,-0.025373038,0.028847033,-0.12851317,0.033993352,0.08744135,-0.006744047,0.05345843,-0.011420429,-0.00094739883,-0.037464336,0.074832514,0.02507177,-4.0708883e-08,-0.022440528,0.036531415,0.007922897,-0.018930163,-0.009302831,0.008803207,0.03663961,-0.0047254306,0.04134405,-0.007603249,-0.009418466,0.14712133,-0.008573392,0.039835986,0.06682381,-0.023076715,-0.059640404,0.0031372386,-0.047592815,-0.0072150747,-0.041095786,-0.022661658,-0.20736063,0.0901944,0.048794053,-0.08698085,0.06616834,-0.063234985,0.05988897,-0.007473856,0.10617375,0.03301499,0.044852953,-0.09615276,-0.036346037,0.031510867,0.007553684,-0.014005736,-0.0043818275,0.030893587,-0.051690158,-0.01655845,-0.03920728,0.008623781,-0.009733918,0.0061198496,-0.008145917,-0.012054302,-0.051065117,0.13941175,0.029554734,-0.03103166,-0.038203713,-0.11315464,-0.026135856,-0.00097495323,0.01865822,0.019001456,-0.0037151694,-0.023214132,-0.012650274,-0.04218879,0.14148417,-0.05365838 +3.13.1.3,The enzyme from Rhodococcus sp. strain IGTS8 is encoded by the plasmid-encoded dibenzothiophene-desulfurization (dsz) operon. The enzyme has a narrow substrate specificity with biphenyl-2-sulfinate being the only other substrate known to date [2].,384,1.0,-0.13724934,-0.018570783,-0.07417206,-0.010397768,0.034722142,-0.028967312,-0.06118268,0.10814216,-0.031275697,-0.017555574,-0.054400492,-0.0011408268,-0.08567816,0.10175136,-0.08811402,-9.8903925e-05,-0.022461765,0.020663481,-0.013183454,0.017715065,0.14505656,0.04310416,-0.047219098,-0.0015488741,0.0625234,0.053788286,0.06695702,0.024561444,-0.015194423,-0.03630236,0.043797478,-0.06861367,0.0917658,-0.056987543,0.05394385,0.08490455,0.053735744,-0.059507392,0.053671267,-0.00060367445,-0.0065547074,0.07095908,0.013000637,-0.023962654,-0.017073331,-0.03899295,-0.034754775,0.05372347,-0.0049009086,-0.03828152,-0.022746667,-0.0030902456,-0.07352235,0.08081676,0.083954655,0.0013610504,-0.061055895,-0.012673562,-0.06412646,-0.027628487,0.013400371,-0.04290986,-0.015498929,0.011410225,-0.017096786,-0.042364605,0.021917693,-0.057165973,0.04188081,-0.08328237,-0.08756148,0.0014487985,-0.03479659,0.005599598,0.028403021,0.08075966,0.0712712,-0.046459526,0.10857857,-0.059331466,0.030143123,-0.03824445,0.011898581,0.09471866,0.017044477,0.0018491723,0.039499763,-0.009692075,0.079208985,0.059118915,0.009000444,0.013617966,-0.022097383,-0.06483256,-0.08729736,0.023005925,0.014826815,0.107239746,0.039165385,0.0011932743,0.03733928,-0.015213196,0.025045674,-0.06864558,-0.09165792,-0.022050126,-0.0019111336,0.09919741,-0.006494595,-0.04060707,-0.017132778,0.100777,0.003008459,-0.007659949,-0.054652028,0.06893757,0.015855312,-0.07321196,-0.07967503,-0.026407178,-0.08673172,-0.048640788,0.0036183435,0.0039308877,-0.049724832,0.04232437,-0.120391056,2.7275846e-33,0.017668756,0.01997422,-0.024570286,-0.0954172,-0.046342727,0.013350595,-0.078434944,0.08300211,-0.06956229,-0.032720603,-0.04884445,-0.02001519,0.030143308,-0.02239352,-0.052679542,-0.0201709,-0.0026899602,0.04193222,0.030052291,0.0033507354,0.07187721,0.05632746,-0.05413517,-0.05118914,0.08003984,0.0024726475,0.007625822,-0.033323426,-0.0015924185,0.0027285179,0.02609294,-0.119771406,-0.058545753,-0.01847025,0.06711188,-0.008849818,-0.044692237,-0.04927425,0.006934083,-0.04781952,0.060610313,-0.0034390881,-0.040610302,0.0117297415,0.027370045,-0.026227351,-0.06648465,0.028328003,-0.018937651,0.09262146,0.02170024,-0.0024334493,0.058873605,0.0009519525,-0.06805925,-0.005709109,-0.0073808827,-0.017587204,0.120903015,0.027280245,0.050728798,0.10837673,-0.022211054,-0.0029827086,0.057517763,-0.057721894,-0.026957978,-0.010957905,0.0023265637,0.11029906,-0.052179195,-0.049999367,-0.011459971,-0.0001881241,0.037751827,-0.06355568,-0.01766051,0.033836354,0.10017077,0.00023438469,-0.021637805,0.028789379,-0.0028815567,-0.05163644,-0.09447638,0.008256912,-0.004675726,-0.015656194,-0.08233354,0.051328834,0.053858068,-0.097537525,-0.052043587,0.0065484904,0.022316685,-3.8324484e-33,0.07079042,-0.059343155,0.0056219674,-0.088315554,-0.0052921833,-0.0029223685,0.084752396,0.022421185,0.040847998,-0.05542043,0.11850098,-0.029737184,0.0224418,0.048060894,0.047828875,0.011615171,-0.04476792,0.01053703,0.04595458,-0.01251154,-0.013280152,0.08192935,0.006612248,0.065568164,-0.0070183133,-0.031694736,0.076596014,0.0809159,0.018725876,0.052206207,-0.045538332,0.047399074,-0.029636022,0.013930832,-0.08589319,0.038240716,-0.012120554,-0.0032205128,0.0066759004,-0.0039677043,0.0109708905,0.023518998,-0.09033388,0.124617755,-0.009930378,0.04904595,-0.0630164,0.061556604,0.0145443315,-0.018883638,0.020224268,0.0055451947,-0.0014516836,0.01834994,0.03230265,0.014976047,-0.043443087,0.004444329,-0.06609054,0.013055817,-0.036716886,-0.039637376,-0.034800895,0.011797536,0.05923387,0.074715465,0.03110943,-0.037519343,-0.04186713,-0.08528796,0.11758678,0.007305071,-0.03034168,0.0010722571,-0.03634704,-0.0861345,-0.03988981,0.08685537,-0.015171697,0.010916262,0.06846218,0.00014655592,0.05723148,0.03862139,-0.00461706,-0.0775248,0.007716982,0.056973614,-0.050102375,0.03938152,-0.034713127,0.0062492215,-0.070748135,0.088365786,0.1085513,-3.8605954e-08,0.005715471,-0.07608046,0.0447564,-0.03591122,0.027341504,0.047079477,-0.010847626,-0.047480498,0.01526715,0.047432605,0.04552287,0.059442103,-0.042380698,0.004550698,0.03872678,0.03354435,-0.1091762,-0.0034786048,0.0040366324,0.07157137,0.003099537,-0.05525721,-0.07878919,0.032103524,0.034351643,-0.026200883,0.0057474617,-0.016707309,-0.011256885,-0.025014004,0.029596796,0.04541569,0.0066351886,-0.015160039,-0.020292206,-0.026266703,-0.053089708,-0.0069417125,-0.07327231,-0.004960566,0.07085036,0.03033564,-0.029226786,0.011297894,-0.00044474946,0.0050993785,-0.020399434,0.028539503,0.026404673,0.022972066,0.037423357,-0.0004311285,-0.02083951,-0.07186023,-0.09146781,-0.04341549,-0.029285049,-0.070159495,-0.07164485,0.028699748,0.09763167,0.019913243,0.13222007,-0.035584126 +3.4.11.1,A zinc enzyme isolated from pig kidney and cattle lens; activated by heavy metal ions. Type example of peptidase family M17.,384,1.0,-0.06659971,-0.019774435,-0.05357193,-0.039769143,0.061207443,-0.02662576,0.040844005,0.08490951,-0.035985462,0.038643643,0.053760502,-0.013108954,0.03140173,0.05471773,-0.07746787,-0.013894065,-0.029350735,-0.04350505,-0.010498,-0.043211553,0.06300945,0.059299994,-0.018703107,-0.0073375152,0.0004892106,-0.016311951,0.0450244,-0.036976784,-0.012225172,-0.019424861,-0.07870963,-0.06508805,0.034474004,-0.052349217,0.035317343,-0.014501479,-0.01029361,0.01680867,-0.021151375,0.0042156167,0.057769552,0.061569046,-0.004222202,-0.1014959,-0.007590423,-0.033201266,0.04988009,-0.022942724,0.042134766,0.01619495,-0.12716193,-0.040052507,-7.405036e-05,0.021486662,-0.0058169356,-0.0078341,-0.119007304,-0.040112857,0.016922414,-0.011244327,0.027551558,-0.019224554,0.019722467,-0.042865362,0.01566437,-0.022376517,0.012177454,-0.03180908,0.0123554375,-0.13663302,-0.016298493,-0.03735382,-0.017966626,0.020860454,-0.10016929,0.046619643,0.05241971,-0.119388334,0.022777904,0.014222042,0.02724417,0.013288769,0.07507989,0.050942153,0.034551743,0.065415636,-0.03441467,0.07454392,-0.037125405,-0.036861178,0.033663012,-0.050557237,0.0147429025,0.0058326474,-0.06157455,0.013707562,-0.05628904,0.0049286825,-0.002659343,0.07637093,0.06318949,0.04901578,0.05068221,-0.08103513,-0.011113703,0.089246005,0.0085424865,0.09019844,0.023830464,0.032797188,-0.043259997,0.029773364,-0.02947094,-0.03054625,-0.016038273,0.06617094,0.035894215,-0.05522353,-0.079593815,0.014800902,0.08050537,0.0451118,0.017660461,0.024908349,0.014706528,0.12580124,-0.056653537,-8.9962046e-35,-0.0068675973,0.014296605,0.054672975,-0.039617848,-0.0006752172,0.04036725,0.003001347,0.06255562,0.007095372,-0.07532949,-0.11270728,-0.01336518,0.028275203,-0.04125345,-0.03076859,-0.052045807,-0.00590227,-0.021794192,0.10994,-0.00033402003,0.01062126,0.06418742,-0.05818679,0.0091170985,0.100060575,-0.014886585,-0.0011653813,-0.05877508,0.02532228,0.0029906495,0.011787749,-0.035105515,-0.07187106,-0.071210526,0.09810605,-0.054661114,0.030166646,-0.0754957,0.0068946364,-0.06746418,0.011832858,-0.00880084,0.01468522,0.048230268,0.10660566,-0.012839658,-0.19548239,0.14015111,0.0028693401,-0.011486521,0.049172208,-0.009368283,0.044473533,-0.049564637,-0.087552994,0.072881274,-0.02255917,-0.002072028,0.07595319,0.047468808,0.030657766,0.042357456,-0.06335548,0.11560536,0.043533523,-0.016467992,-0.09072042,-0.017084116,-0.07650013,0.099061176,-0.07968185,-0.046744633,0.006032788,-0.027232794,0.01625764,-0.12235916,-0.04422022,-0.02558657,0.023944527,0.0021163442,-0.029168092,0.02941318,0.0415289,0.049369305,-0.07129569,-0.029168874,0.0005970289,-0.022385148,-0.04482692,-0.061669357,0.05162568,0.037411496,-0.10802246,0.009919726,-0.032434322,-4.274798e-34,0.06798194,-0.007938106,0.065712675,-0.009186306,0.012035223,0.038343776,0.057840843,0.01398002,0.04575048,-0.04142758,0.047231425,-0.03290477,0.017424801,-0.04572456,0.042844877,0.058030616,-0.032294914,0.0817824,0.03268676,-0.018282583,-0.10418308,0.05024554,0.05711789,0.020014392,0.04885175,-0.008983003,-0.041680604,0.013400927,0.047832802,0.018935308,-0.06646594,0.022444183,-0.0006873516,-0.08672058,-0.09783682,0.049017407,-0.024813423,-0.051032793,0.028216526,-0.009669598,-0.027930858,-0.02352142,0.016129052,0.07441924,-0.029787788,0.084997244,-0.034868445,0.012549845,-0.041003976,-0.059765562,-0.004429931,0.022029102,0.0059356205,0.010719498,0.071559064,-0.0047273147,0.07123699,0.013201861,0.011415389,0.015458492,0.072115846,-0.018183382,-0.00039162682,0.0053074807,0.048680782,0.0041843946,-0.00014367144,-0.013432388,0.046256635,-0.04871571,0.09851237,0.06327444,0.035274137,0.024206294,0.0042356,0.036931552,-0.03493213,-0.021566642,-0.056102958,-0.027359635,0.08627937,-0.01583764,0.04977222,0.08900558,-0.0057165963,-0.072621875,0.040991575,0.11679663,-0.009956216,0.023722753,-0.062025413,-0.04627173,-0.01824169,0.069376774,0.034807608,-2.3952792e-08,0.039755438,-0.058704693,0.02246358,-0.112953365,-0.052820046,0.013939704,-0.04333755,-0.024610866,0.0067649274,-0.04264616,0.020893872,0.05195733,0.0019068553,0.07739668,0.022366347,0.07227866,0.024633165,0.010431652,-0.01644929,0.0971662,-0.07172494,0.029206382,-0.08278716,0.009443366,-0.002581856,-0.07471211,-0.0034174493,0.09763703,-0.014397747,-0.017121485,-0.022964228,0.0033576388,0.025489012,-0.027936276,-0.06464997,0.056750663,-0.03916672,-0.024651535,0.0010147596,-0.043693125,-0.062637426,-0.06283651,-0.0032334246,-0.041696824,-0.008879261,-0.0838327,0.008908255,0.011379915,0.034952402,0.018910985,-0.030275363,0.011317389,0.0036297964,-0.09770008,-0.030218147,-0.0034778062,0.028647352,-0.113169014,0.051859964,-0.06167541,0.08522136,0.033255614,0.102296375,0.045454357 +3.4.11.2,"A zinc enzyme, not activated by heavy metal ions. Type example of peptidase family M1.",384,1.0,-0.07198819,-0.03651363,-0.09167088,-0.022449603,0.07009235,-0.020197114,0.021409994,0.077265985,-0.02183099,-0.00440677,0.060125113,-0.017421955,0.03566509,0.034467887,-0.04523115,-0.0063248915,-0.01696021,-0.023100153,-0.046073385,-0.036727123,0.063334554,0.027647948,0.01711738,0.026475292,-0.051066916,0.017898735,0.026453018,-0.027459236,0.02429273,-0.012945249,-0.05827076,-0.0056442884,0.08574481,-0.032952465,0.06304682,0.054870225,-0.06372985,0.022770502,-0.03176505,-0.0067169103,0.08003403,0.096981056,0.033478834,-0.088744216,0.0055035683,-0.097747944,0.027922586,0.012165689,-0.022104885,0.01685858,-0.07893747,-0.10150095,-0.017641747,0.023547819,0.008116011,-0.017554654,-0.07895466,-0.031228293,0.0042765955,-0.011874304,0.030615872,0.0018541061,-0.007910352,-0.036012303,0.035627116,-0.028686099,-0.0038251078,-0.030345099,0.004205824,-0.040754635,-0.006512024,-0.08576895,-0.07946988,0.040674616,-0.044484083,0.011065881,0.079436176,-0.119112186,-0.01780671,5.545798e-05,-0.07149193,0.01257625,0.07921384,0.05837511,0.054237008,0.08076197,-0.0087341955,0.030973759,-0.007896341,0.001646062,0.078571685,-0.02518029,0.049609292,-0.0020653463,-0.0694531,0.043671895,0.0065440033,-0.0069459947,-0.014789002,0.052757062,0.07193975,0.051306773,-0.002190142,-0.039804984,-0.029858783,0.08859429,0.0033553746,0.04134926,0.023708733,0.0665508,-0.026075607,-0.029783498,-0.008276654,-0.048888188,-0.03358533,0.02032471,0.041245144,-0.01852593,-0.03440976,0.019621592,0.02764025,0.009311471,-0.016543958,0.0008805792,-0.022205153,0.1340129,-0.07633515,-7.3445236e-34,-0.019249681,-0.0131935645,0.06867693,-0.028621817,-0.021337891,0.023054997,-0.0102416705,0.026318744,0.026634075,-0.062166013,-0.07488138,-0.036966864,0.0042368853,-0.011866554,-0.062605396,-0.035157643,-0.018761994,-0.031210063,0.10146016,0.040840458,0.003969379,0.0989974,-0.048745707,-0.01982997,0.09088502,0.024302136,0.041122667,-0.028023373,0.0077816388,-0.005158829,0.015691932,-0.036595795,-0.103918165,-0.029673075,0.060760807,-0.015618541,0.030373545,-0.05574428,0.01626885,-0.061282035,-0.033470143,0.009603314,-0.052765194,0.058073603,0.11924175,-0.05560022,-0.106401466,0.08337699,-0.006011945,-0.0048328703,0.01577305,0.03159277,0.058295462,-0.023660861,-0.09996768,0.08545966,0.024465188,0.060164,0.08648262,0.093216754,0.0008700943,0.045392606,-0.055733096,0.121936105,0.011047709,0.011476671,-0.10395341,-0.060679905,0.0027681163,0.12214407,-0.05771171,-0.009908151,0.05884207,0.015548709,0.02656262,-0.124316216,-0.046156395,0.013717741,0.029876232,0.015728073,-0.03815433,-0.033761468,0.037922584,0.04064617,-0.10258779,-0.044261273,-0.052703973,-0.009985423,-0.048647594,-0.024193373,0.018927112,0.009631424,-0.042101234,0.032182623,-0.053551782,-8.025438e-34,0.07643395,0.00023458243,0.051872205,-0.03625953,-0.004047617,0.008011031,0.008647774,-0.03859384,0.028958924,-0.023653163,0.085170865,-0.025552321,-0.006838238,-0.054005478,0.042058885,0.058832787,-0.03452816,0.12203326,0.0110054035,-0.0059182695,-0.08589246,0.059739947,-0.011792458,0.012894584,0.024293907,-0.022574818,-0.06014099,0.05898779,0.044392176,0.010841908,-0.04270533,0.05954039,0.003783525,-0.071097605,-0.11057412,0.047863364,-0.018100765,-0.028498355,-0.024638975,0.013301206,-0.015402547,0.029214518,0.05200189,0.15990129,0.006841022,0.08775049,-0.089243695,0.027155379,0.00072320126,-0.067151725,-0.006227619,-0.025746591,-0.011633705,0.032256033,0.09312651,-0.015508662,0.03921622,-0.0029133107,-0.060638934,0.016648483,0.03593375,-0.04267082,-0.015680932,0.029003147,0.027535914,0.019258218,-0.036089107,-0.009006928,0.05359208,-0.0105171455,0.10913821,0.07505442,0.056633104,-0.042165156,-0.05179937,0.033556335,-0.04294773,-0.06655085,-0.040717114,-0.07861465,0.04775775,0.036056973,0.023120064,0.024985485,-0.018943988,-0.083824486,0.0023630033,0.085166276,-0.025108652,0.071334414,-0.033119287,-0.06844421,0.0056268754,0.07060639,-0.016205091,-2.3793348e-08,0.034461662,-0.035863377,0.05338121,-0.11002537,-0.057038385,-0.004102296,-0.020992968,-0.060102277,0.044314448,-0.0278676,0.0057356283,0.04251433,-0.0101269,0.04868017,0.037597537,0.047103293,-0.022481484,0.0064527397,-0.033417415,0.055496287,-0.07121894,0.06036971,-0.087096214,0.034908175,-0.0024776028,-0.064013876,0.033219375,0.10588575,-0.04346832,-0.032797165,-0.047341693,0.013284491,0.0065116207,-0.0056704567,-0.015893936,0.031223502,-0.013683445,-0.04894838,-0.023071073,-0.057736456,-0.034457218,-0.08585387,-0.0665095,-0.046827994,0.0039941766,-0.043973826,-0.0461412,0.00814196,0.042376366,0.016856862,0.01675287,-0.010188366,-0.01407928,-0.07298378,-0.05852112,0.06417093,0.017798848,-0.083956696,-0.0056044487,-0.10002725,0.12996916,-0.024118248,0.1722722,0.025069984 +3.4.11.3,A zinc-containing sialoglycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family),384,1.0,-0.070324875,-0.05801436,-0.08211509,-0.051919878,0.07359642,0.04057557,0.07421663,0.061585672,0.054049138,0.00028775484,0.03619055,-0.0064580287,0.016352134,0.036834933,0.017446633,-0.004217031,-0.050663795,-0.0015582009,-0.034334622,-0.06218724,0.066815674,0.03350492,-0.027226886,-0.038309883,-0.014900415,-0.02857144,0.019931674,-0.048625,-0.011580468,0.0026139363,-0.06804697,-0.12439561,0.043437406,-0.021106243,0.11346783,-0.0064463,-0.04010347,-0.026519647,0.016562644,-0.067052834,0.08469662,0.108697586,-0.06887556,-0.06589911,-0.0408424,0.00021951395,0.036727834,0.06843124,0.008546565,0.041949734,-0.058300123,-0.11841619,0.02695573,-0.014593152,0.029980188,0.07601584,-0.08424682,-0.04435868,0.006411054,0.056090254,0.027479826,-0.055258293,0.005612711,-0.0431638,-0.02876296,-0.029534616,0.036105175,-0.02106932,0.025691787,-0.04040557,-0.036435273,-0.0077053225,-0.045510143,0.06477977,-0.016981348,0.04957846,0.0407948,-0.074204475,-0.018996816,-0.027750134,0.012729569,0.048908986,0.061495133,0.063304655,0.07330935,0.039838564,0.040955443,0.026152544,-0.03452708,-0.0259971,0.05294458,-0.069319494,0.059116542,0.020765232,-0.06738106,0.009613629,0.030771332,-0.06342039,0.0036032363,0.019173184,0.06283075,0.060027342,0.07108666,-0.08238845,-0.005893884,0.12540981,-0.015582081,0.072656244,0.016066905,0.04755116,-0.010866874,-0.009096944,0.03543109,-0.0064819492,-0.001972562,-0.03531565,0.055711947,-0.004768661,0.0015309864,0.03375853,-0.007681297,0.025193948,0.0022906242,0.009668211,-0.009243181,0.11459131,-0.094340205,2.0363915e-33,-0.026115295,0.052413367,0.030901743,0.013440955,-0.018645668,0.015088127,0.03782724,0.021733208,0.033193395,-0.045890562,-0.12624522,-0.14472316,-0.039023492,0.0029202392,-0.10312535,-0.011382912,-0.033979934,-0.010563609,0.056229357,0.03724382,-0.07575834,0.08554337,-0.0025069702,-0.10416973,0.083330944,-0.0075859074,-0.0013470527,-0.014993117,0.08606448,-0.0071269707,-0.01569109,-0.03845385,-0.11548401,-0.04285868,0.09254564,-0.051092662,0.08078069,-0.057528574,0.035249583,-0.031542044,-0.009893934,0.0025985057,-0.05427861,0.025770681,0.046576984,-0.013979182,-0.0821275,0.085970126,0.007453134,-0.08081057,0.0031222447,-0.0048530237,0.019482007,-0.011155476,-0.08969978,-0.0042024795,-0.0032476317,0.024816984,0.09148191,0.058812756,0.066119194,0.04751858,-0.02676248,0.07324773,0.04678676,0.004091208,-0.09724538,-0.029353842,-0.030302951,0.074316196,-0.0033153133,-0.017519902,0.05771575,0.053255305,0.019164477,-0.17194496,-0.021234665,0.024949277,0.07090358,0.059120513,0.05409038,0.066044345,0.008701901,0.004827031,-0.09729385,-0.08078491,0.063355684,-0.05106993,-0.056721352,-0.0065260064,0.008255199,0.013959637,-0.034942362,0.059391838,-0.110526495,-2.7228585e-33,0.080823936,-0.031648036,0.1017455,-0.056293577,-0.037585232,-0.03847517,0.011274147,-0.009762089,0.03528664,-0.03583064,0.10008503,-0.020645887,0.013272052,-0.057218596,0.050171863,0.011626298,-0.057091836,0.054981902,0.029864747,0.0034877022,-0.05296102,-0.036060005,0.044385087,0.03846548,0.009051369,-0.03669639,-0.032776594,0.065936625,0.03285709,0.056509677,0.0082892645,0.05997086,-0.05480888,-0.087056614,-0.13340035,-0.004707718,-0.028200831,-0.05692209,0.03190277,-0.060098283,-0.021344475,0.015639814,0.02308168,0.05426044,0.018913457,0.05962981,-0.015828079,-0.017629463,-0.06498863,-0.03199122,0.008049485,-0.039334483,-0.006974897,0.031979863,0.06766982,0.021247838,0.01800147,0.023960108,-0.02482562,-0.016259108,-0.020702133,-0.00772901,-0.035334706,0.041559808,0.07469033,0.028280443,-0.024944602,-0.014764319,0.09576059,-0.0015684799,0.0058734883,0.059414115,0.0060455105,-0.013159713,-0.021597857,0.056887124,-0.10667704,-0.054845143,-0.046594605,-0.018891728,0.013759072,0.016549442,-0.067239605,0.04993972,-0.008963926,-0.03831205,0.034833185,0.09686656,-0.013859801,0.08047923,-0.019251572,-0.05918135,0.0005510351,0.09790877,-0.009912692,-2.5523907e-08,0.057856377,-0.0036942188,0.0231796,-0.13118617,-0.11229707,-0.033208083,-0.0039097737,-0.050945435,-0.0044112126,-0.01668185,0.040291987,0.024113711,-0.037649605,0.028464437,-0.03144393,0.08672105,-0.04638803,0.04300685,0.02117418,0.07655487,-0.038653653,0.09894423,-0.06518163,0.022098541,0.051800754,-0.039978273,0.025665754,0.07683917,-0.027360622,0.0063102106,-0.0019203351,-0.0257499,-0.025927272,-0.029543523,-0.0027891796,0.010054541,-0.011055465,-0.021626696,0.0026303947,-0.036309816,0.019325748,-0.040027227,-0.03837648,-0.033686277,-0.010524639,-0.074475825,-0.04762408,0.032183,0.009948425,0.011618249,0.016015029,-0.008148066,-0.036613103,-0.060404025,-0.05466762,-0.0039618057,-0.043776456,-0.03792264,-0.0035798368,-0.04052855,0.013998232,0.008925758,0.13257279,0.03844628 +3.4.11.4,"A zinc enzyme, widely distributed in mammalian tissues. Formerly EC 3.4.1.3",384,0.99999994,-0.10140772,0.026326392,-0.03269667,0.038599182,0.043027822,-0.02868109,-0.01692933,0.029928274,-0.03818373,0.041229945,8.8175875e-05,0.0044753235,0.016201174,0.06975845,-0.045329884,-0.033072833,-0.045110457,0.014081301,-0.04856802,0.011223666,-0.0083821,0.06303405,0.056412097,-0.018323772,0.04188318,-0.06865135,0.031596273,-0.020482661,-0.04028711,-0.0017070661,-0.0633379,-0.049718704,0.071103364,-0.034981176,0.0022329064,-0.0126969945,-0.055361025,-0.032589197,-0.045136508,0.05666952,0.09234072,0.07493306,-0.0067871725,-0.07010134,0.008676515,-0.016714223,0.028153649,-0.060267873,0.008876315,0.054432057,-0.06563583,-0.066051684,0.014423132,0.060709387,-0.048002,0.006786432,-0.13028565,-0.028299619,-0.036580164,0.014265517,0.031515308,-0.06978785,-0.004340233,-0.013873694,0.09604112,-0.009224943,0.036933165,-0.048483837,-0.052118883,-0.07657022,-0.053503957,-0.021072632,0.004371241,0.06304124,-0.06581668,0.04108848,0.06636796,-0.0688871,0.04414452,0.019860895,0.03450219,-0.02826777,0.03091801,0.08152669,0.07238591,0.086592704,-0.054765854,0.08045201,-0.106350064,0.0391255,0.026045982,0.001706847,-0.0056144767,0.052632123,-0.11786995,0.06938098,-0.0011064095,0.09844291,0.062162958,0.017514432,0.032986872,0.06121489,0.06686353,-0.100968614,0.015307173,0.053986434,0.035059873,0.06091963,-0.009079891,0.075617865,0.019237053,-0.026268834,-0.049364284,0.013826679,0.0005207043,0.061602894,0.010640476,-0.0030723566,-0.030537285,-0.006210293,0.028907536,0.024456037,0.04278824,0.010474225,0.0052339984,0.10728516,-0.029836234,-4.4435927e-33,-0.04209155,0.015835466,0.033152036,0.020380026,-0.025918543,0.09505696,-0.028330887,0.07088849,-0.054850686,-0.044900525,-0.101427555,0.00028794984,0.0678561,-0.020923013,-0.065469906,-0.07845741,0.0071201036,-0.029354006,0.06713322,-0.015515344,0.08246488,-0.0280004,-0.057898656,0.03461537,0.0008857663,-0.034499142,-0.068775,-0.01318105,0.03881919,-0.032037616,0.018747902,-0.050470974,-0.029650837,-0.05050065,0.116531804,-0.011712304,0.014886438,-0.025382536,0.007422893,-0.050297536,0.020743411,-0.063106425,-0.0011170008,0.012359983,0.028284172,-0.020807972,-0.14519209,0.07209581,0.0737566,-0.07017851,0.065906726,0.031678397,0.08115707,-0.040070888,-0.11379482,0.032181427,-0.059319332,0.010353421,0.010276406,0.082740985,-0.012206727,0.07620022,-0.05211651,0.099380344,-0.001183087,0.02157128,-0.119140774,-0.059586544,-0.081608094,0.09905293,0.0068211285,-0.07433158,0.047470514,-0.052605264,0.028084766,-0.02360299,-0.028386828,0.037804022,0.031555846,-0.029434681,-0.06694673,-0.033793814,-0.02906633,0.065193295,-0.031058447,-0.050307624,0.026101822,-0.02181491,0.04600336,-0.02043664,0.09687604,-0.024436178,-0.057933975,-0.028213544,-0.012475474,1.7601818e-33,0.040355917,0.02316449,0.017637197,-0.023586206,-0.0049430463,0.03452044,0.026036542,-0.008034756,0.03782215,-0.018536432,0.105501726,0.013292992,0.08269501,-0.03705483,0.061115332,0.051186603,-0.067011744,0.047086794,0.064247705,-0.035911333,-0.034453724,0.008771016,0.023486197,0.05316638,0.045635726,-0.0019089477,-0.010965343,0.013049489,0.061113432,0.05421935,-0.07562271,0.03916469,-0.029732922,-0.07643946,-0.023514587,-0.0032356274,-0.015809197,-0.0861392,0.03502098,-0.022546893,-0.047438487,-0.014069436,-0.04127549,0.12077132,0.09669049,0.09796626,-0.049956635,0.03230721,-0.06626951,0.004096018,-0.015210212,0.06477351,-0.019948678,-0.030571442,0.048345614,0.057058726,0.007365171,-0.016499631,0.016604273,-0.039305028,-0.0021479344,-0.032836657,-0.002114588,0.030893015,-0.005243017,-0.0032985897,0.03211975,0.04233436,-0.0295477,-0.0034436053,0.0729897,0.113216735,-0.037608575,-0.027433733,-0.02755869,0.035284314,-0.028733043,-0.011188762,-0.048839513,-0.0070848,0.046393886,0.049291223,0.010923946,0.011465295,-0.0006551019,-0.094552405,0.005716979,0.11420462,-0.031272277,-0.0009914672,-0.08985256,-0.07210087,-0.119250014,0.03415138,-0.054202147,-2.4861313e-08,0.015129218,-0.009762516,0.0041281176,-0.10432318,0.021771437,0.045494728,0.027611407,-0.010090642,0.055856947,0.010705936,0.014311947,0.057274893,0.020203743,0.03640503,0.025501017,0.017258335,-0.048173923,0.0047571836,-0.026500389,0.04418992,-0.016880237,0.038722962,-0.10563842,0.03601714,0.02942818,-0.05686407,-0.045306478,0.098655984,-0.06908362,-0.059807166,-0.004073413,-0.022281287,0.099545576,-0.009728375,-0.070086904,-0.015570486,0.010677321,-0.06277446,-0.057896513,0.004992664,-0.057248827,-0.047013976,0.006402722,-0.022254374,-0.04323394,-0.09710501,-0.0020703424,0.03788762,0.065970644,-0.011213814,-0.0739304,-0.039415788,-0.05172442,-0.058623035,0.0325359,-0.0072323475,-0.062726915,-0.08450101,-0.030541971,-0.026490888,0.02375951,0.04219133,0.13242072,0.003544372 +3.4.11.5,"A Mn2+-requiring enzyme present in the cytosol of mammalian and microbial cells. In contrast to the mammalian form, the bacterial form of the enzyme (type example of peptidase family S33) hydrolyses both polyproline and prolyl-2-naphthylamide. The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1, leucyl aminopeptidase.",384,1.0,-0.073965564,-0.07507938,-0.073064156,-0.0462519,0.07772963,0.03687709,-0.015009256,0.11638109,0.03529535,0.066883944,0.040753257,0.016476467,0.012588087,0.08231009,-0.026767768,0.0061972975,-0.08615165,-0.07164388,0.0058214027,-0.0015408865,0.0921502,-0.00049836014,-0.031823147,-0.014548299,0.041505374,0.047538668,0.09292175,-0.037767522,-0.036240157,-0.022292264,-0.01944352,-0.07510325,0.09815409,-0.079047516,0.16683972,0.039154798,-0.00029020585,-0.008007925,-0.000580079,-0.018136926,0.0445623,0.005524184,-0.018139249,-0.08945071,0.028499298,-0.01229383,0.032937966,-0.060112208,0.01629952,0.050172694,-0.028057372,-0.054873217,-0.036336042,-0.008150701,-0.018011961,0.008472677,-0.05259802,-0.025001554,-0.020788174,-0.002872498,-0.016812189,-0.024331274,0.017612834,0.0151907075,0.008099442,-0.03576983,-0.0155657185,-0.022330524,-0.0017595622,-0.00097408757,-0.03256942,-0.029547997,-0.049520224,0.10182627,0.023889309,-0.066000454,0.040857416,-0.041859623,-0.035189725,-0.052368503,-0.035600815,-0.01888954,0.062411647,0.028761974,0.04023271,0.064152494,0.054027688,-0.0038029973,0.012668623,-0.011125306,-0.039520595,-0.021651598,0.023192564,0.029035462,-0.0713823,-0.0022242495,-0.025524141,-0.039547775,0.026364625,-0.0026537413,0.0166861,0.014504787,-0.041068166,-0.12664516,0.04624903,0.05315658,0.013408979,0.06339277,0.060012452,0.015377895,0.038087122,0.026886245,-0.032559082,0.035671137,0.026860908,0.018531295,0.05041213,-0.025501901,0.025366945,-0.037107803,0.057231236,-0.022901233,0.04125905,0.035204913,-0.04241707,0.0570594,-0.046951436,1.2365757e-33,0.05413247,-0.030759024,0.013570995,0.020207014,-0.003572683,0.050157804,-0.025284607,-0.0070371176,0.04681377,-0.08271414,-0.12839018,-0.10570564,0.03496003,0.043555047,-0.03194848,-0.017620381,-0.039529398,-0.048380848,0.08860348,0.04284422,-0.035554647,0.08378315,0.023909662,-0.05220918,0.09242753,-0.04437797,0.07884579,-0.027802115,0.085286915,-0.01802543,-0.014296553,-0.1287607,-0.06941979,0.032721464,0.036696084,0.051156055,0.011457372,-0.056480963,0.0056641623,0.060030513,-0.011071934,-0.0053452286,-0.022419266,-0.03558605,0.062420134,-0.017237533,-0.060695514,0.06783353,-0.08805005,0.0069000754,-0.0011243932,0.043846235,0.061402544,-0.007404847,-0.09519463,0.026413405,0.013945831,0.030310972,0.019188259,0.099057116,0.00034755436,0.0656587,0.00038433232,0.03344535,0.02215713,0.019667173,-0.048797607,-0.053497203,0.0056841467,0.08972285,-0.05905145,-0.018832926,0.093142144,0.016205082,-0.024099017,-0.11829109,-0.089136496,0.029784575,0.04066401,0.062480204,-0.030996384,0.012657612,-0.026212763,9.694433e-05,-0.0875701,0.016174434,0.009098438,-0.109010935,-0.00446796,0.0018220473,0.079111375,-0.053631257,-0.024232551,0.04877287,-0.03835986,-3.490942e-33,0.027132556,-0.074497804,0.078510314,-0.038557038,-0.085904956,0.011742704,0.016602954,-0.022570528,0.009565133,0.009564375,0.1140839,-0.0098296255,-0.010361473,-0.028953064,0.025152076,-0.013204608,-0.034625724,0.08268881,0.03551642,0.0028872204,-0.015553612,0.030234197,8.411685e-05,0.06202753,0.042842045,0.010430714,-0.052492976,0.06460743,-0.00012672757,-0.04536575,-0.029953621,0.028275536,-0.056903392,-0.117493704,-0.012030098,0.037321884,-0.061547022,-0.037329886,0.005687261,-0.058982965,-0.021608355,0.05225906,0.034719992,0.090347156,-0.014088738,0.042512204,-0.071541816,0.019823799,0.023332074,-0.0180478,-0.08198968,-0.06257107,-0.011111596,-0.023457969,0.030889597,-0.037627306,-0.013778604,0.032194797,0.009221462,0.010153843,-0.018023694,-0.05988246,0.022424595,0.036935512,0.04467838,0.018574413,-0.034466796,-0.042299114,0.054300256,0.033334814,0.064787865,-0.018925129,-0.01838373,0.027734155,-0.045660235,-0.025450679,-0.03491131,-0.011229944,0.00646555,-0.048052736,0.046501078,-0.006424913,-0.019355508,-0.04854396,-0.039780788,-0.06682351,0.041372128,0.15228039,0.01223481,0.058102738,0.022839095,-0.02850341,-0.055030096,0.09654319,0.038711865,-3.853538e-08,0.02643663,-0.07515622,0.021050744,-0.091766365,-0.04580439,0.0051444597,0.0040537016,-0.05156285,0.08523149,-0.061541505,-0.025484975,0.07421486,-0.058239743,-0.011478436,0.005768121,0.121138416,-0.019073471,0.031713724,0.008997498,0.035659898,-0.06603861,0.009498709,-0.1923975,0.091542,0.0027805935,-0.02124871,-0.002301687,0.10274288,-0.025977539,-0.052383453,-0.026234929,0.02267816,0.031408947,-0.051161963,0.010477494,0.036880963,-0.02049666,0.012663143,-0.01010446,-0.00020135248,-0.01733805,-0.00013637831,-0.0150081515,-0.0366989,0.025989592,-0.034539476,-0.025335386,0.013647886,-0.053863704,-0.053834233,-0.055106707,-0.049690824,0.003525428,-0.10211208,-0.082921006,0.09499274,-0.055216916,-0.1036307,-0.031105682,-0.03269551,0.057571698,0.014748141,0.18434492,0.028746799 +3.4.11.6,"Cytosolic or membrane-associated enzyme from mammalian tissues, activated by chloride ions and low concentrations of thiol compounds. This is one of the activities of the bifunctional enzyme EC 3.3.2.6 (membrane alanyl aminopeptidase family) [4,5].",384,0.99999994,-0.015987188,-0.023776278,-0.039803453,-0.05691882,0.00060184766,0.03425268,0.09172393,0.06064424,0.08871283,0.043745387,0.022278486,-0.05945192,-0.029824413,0.07161055,0.00442357,-0.0059443465,-0.055419262,0.024874948,-0.041700978,-0.10126532,0.03176392,0.017562643,-0.07340142,-0.03121545,-0.016670436,0.010139888,0.06604426,-0.052334808,-0.03964805,-0.004036054,-0.11035613,-0.10750368,0.10666274,-0.0074635176,-0.018435698,0.085537255,-0.12215909,-0.06119308,-0.04423512,-0.028056541,0.08212097,-0.034332164,-0.073535554,-0.046341296,-0.013060572,-0.023247935,0.04204927,-0.020082967,0.033790078,0.085038394,0.044333514,-0.023852434,0.011579301,-0.006013016,-0.09173204,0.031434417,-0.09910093,-0.0070606074,-0.008350238,-0.022714684,0.025415897,0.021760765,0.015684739,0.014500738,0.01811465,-0.04617029,0.051448885,0.0025298416,0.0118174935,-0.060203847,-0.013047493,-0.027733246,0.008986846,0.00049538,0.046936825,-0.0167652,0.015166759,-0.06103902,0.011104567,-0.062355544,0.048070848,-0.029903866,0.0007152656,0.09858359,0.02428001,0.012155584,0.0331314,-0.010267298,-0.047110163,-0.002794802,0.070761584,-0.05682773,0.0026889087,-0.032865994,-0.071209036,0.04093926,0.0031355552,0.036035642,0.031333756,-0.0156146465,0.026842412,0.108199015,-0.036754802,-0.061934717,0.028982513,0.070361264,-0.0072117,0.04493325,-0.018052278,-0.03160843,-0.0284123,-0.02233879,0.0057551856,0.030600047,0.03405443,0.103490576,0.050050236,-0.06901991,0.011246198,0.020482207,0.012774053,0.011346718,0.039813872,0.10401634,0.0042999894,0.07573266,-0.06465771,8.702617e-34,0.03245713,0.007575674,0.037278324,-0.013231574,-0.0065126983,-0.005363679,-0.0030429366,0.059893336,-0.029592285,-0.041052878,-0.06886259,-0.06267705,0.072992735,-0.027636956,0.02256024,-0.021690192,-0.063418984,-0.0137124,0.108391695,0.0003357818,-0.021158721,0.014604766,-0.0016864965,0.026950015,-0.0032858257,-0.047891807,-0.046114773,0.03133574,0.10983192,0.0059802793,-0.0066777375,-0.064188585,-0.07531946,-0.00083209795,-0.030448046,0.055025112,0.0029036098,0.024611996,0.016257845,0.042347476,-0.006419208,-0.040607866,0.035726186,-0.078123905,0.042392418,-0.08962288,-0.14300455,0.07920089,0.038446303,0.023238013,0.06604787,-0.094476216,0.07203592,-0.08304341,-0.03472434,0.036880296,-0.021343386,0.023260847,-0.03838961,0.11481411,0.049207035,0.049268954,-0.093778886,0.09130162,0.025758486,0.050438993,-0.030963961,-0.082243346,-0.035398193,0.045800798,-0.058326736,0.030589385,0.054770306,-0.054306295,-0.010177252,0.016497802,-0.09583456,0.033303987,-0.031862155,0.03869712,0.05667157,0.012790724,0.028089242,0.046285022,-0.018039512,-0.047949165,0.059186947,0.009309157,-0.0238844,0.002811556,0.073241375,-0.031141348,-0.11821451,-0.011410063,-0.013158116,-2.2738665e-33,0.11320984,-0.064330876,0.066774495,-0.023546785,-0.03866871,0.064986594,-0.016548902,0.008292222,0.023341747,-0.0024556257,0.0861714,-0.023474397,0.034626383,-0.06593879,0.01712054,-0.038901288,-0.044067476,0.03553406,-0.011029467,0.013608889,-0.103063785,-0.028524535,0.030250518,0.02973268,0.036805965,-0.055320982,-0.036711607,0.06344283,0.033748537,0.041403785,-0.088687666,0.025195226,-0.02735536,-0.02991943,0.013849561,0.03112619,0.00391081,-0.01794996,0.057587545,0.00074762537,-0.043573264,0.041763622,0.040837083,0.04663422,0.002366851,0.1407738,-0.012410372,-0.0068898606,-0.04742673,-0.07830179,0.035183534,-0.0735094,-0.013887049,0.049777273,0.0051249177,0.10383831,0.0109779425,0.0027127145,0.053346884,-0.049810134,-0.014647245,-0.031595346,0.010025358,-0.06352369,-0.0023256883,-0.024070755,-0.119171165,0.051225364,-0.026631279,-0.019439481,0.09269121,0.014614534,0.0027207101,-0.023298588,-0.03852679,-0.037523784,-0.05608945,-0.02964792,0.030252442,-0.03908667,0.032173086,0.04433881,-0.05276108,-0.024555098,-0.013198018,-0.037038393,0.0021873459,0.14565626,-0.0061169923,0.05803007,-0.035122074,-0.043787785,-0.07929697,0.08762208,0.03046377,-4.2011866e-08,0.021489222,-0.01432054,-0.04567832,-0.09079306,0.0024481188,0.089744106,0.060876634,0.03799708,-0.0061034244,-0.0119455885,-0.06996182,0.03010503,-0.024399087,0.024337405,0.012771605,0.077845514,-9.700761e-05,0.055962518,0.027378786,-0.042195477,-0.02140514,-0.03006873,-0.115876794,0.038156588,0.069163896,-0.030544631,0.049699455,0.0057586636,-0.0047434433,-0.047611643,-0.038176518,-0.02213367,0.019488985,-0.049246296,0.0044651823,0.028334945,-0.039774332,-0.044285994,-0.06838809,0.008861724,0.022657381,-0.028323224,-0.07911311,-0.041735336,0.032324206,-0.028596785,0.0484442,0.092926614,-0.012610459,-0.05385172,-0.043600965,-0.054584283,0.020410674,-0.046719197,-0.06873492,0.020796046,0.0031652383,-0.13421851,-0.012482897,-0.022315394,0.042048987,0.10675449,0.17058627,-0.0013998385 +3.4.11.7,Ca2+-activated and generally membrane-bound. A zinc-metallopeptidase in family M1 (membrane alanyl aminopeptidase family),384,0.99999994,-0.058764372,-0.07040278,-0.0125670815,0.025693024,0.015400804,0.047851868,0.07901812,0.062411446,0.07343836,0.013324596,0.017329829,-0.04355961,0.0052677644,0.07347818,-0.025219843,-0.035199482,-0.026010158,0.0061221863,-0.08968975,-0.04736512,0.13238706,-0.028550543,-0.04665427,-0.09460372,0.009537306,-0.009371069,-0.046335835,-0.035253458,0.04217144,0.022782182,-0.079933584,-0.07256096,0.02841818,-0.019903067,0.06750913,0.044352688,-0.071206,0.0022732054,-0.06711377,-0.10910185,0.06987621,0.10428581,0.0132467,-0.019763429,-0.03127453,0.034778,0.07391758,-0.0141872745,-0.03455189,0.0638975,0.018215211,-0.075622,0.011474015,0.054420974,0.0199894,0.073688775,-0.08511303,0.06758924,0.05665369,-0.01690377,0.02114631,-0.049103532,0.022505866,-0.029343093,0.030967252,0.0033607378,0.017548775,-0.028936468,0.020764368,0.012048232,-0.04979574,-0.020197911,-0.014592304,0.021375213,0.036086757,0.040766,0.0044316687,-0.06473709,-0.015929332,-0.086277075,0.054177,-0.028785776,0.020928813,0.05643667,0.05038531,0.07375946,0.05190222,0.0034127538,0.0030907947,0.0073049027,0.052663002,-0.025763426,0.05017143,0.0048010075,-0.1075918,-0.009291229,0.022894304,-0.010938804,-0.06839259,-0.006022183,0.06689735,0.110110946,0.02900431,-0.07074908,0.025415793,0.04725187,-0.031818263,0.026823884,-0.043218184,0.018047176,0.07428479,0.026193434,0.016349055,0.046105288,0.07993521,0.04896467,0.049131263,-0.02750733,0.00046786814,0.00021513418,-0.041859686,-0.035154555,-0.053824298,-0.020521272,-0.05046237,0.09177606,-0.081197016,9.326603e-34,0.0039025282,0.026486035,0.053385362,0.008674018,0.037447542,-0.05568031,0.03466999,0.013298657,0.032207996,0.033840097,-0.067578085,-0.13729768,0.0027842615,0.0067496668,-0.0387045,0.018191746,-0.07555265,-0.06367842,0.08345279,0.03225189,-0.02669116,0.083336614,0.00441241,-0.00353201,0.0958533,-0.015051335,-0.061134048,-0.02540283,0.04873749,-0.014419806,0.0087546,-0.02867265,-0.123774484,-0.008762841,0.096361786,0.002234264,0.1201211,-0.06720912,0.03952902,0.0022653348,-0.030948,-0.00920953,0.03659924,0.035801277,0.078368455,-0.1461001,-0.12803435,0.05337951,0.038165282,0.022770353,0.017758233,-0.0059277057,0.036318973,-0.038330957,-0.083990045,-0.015392778,-0.019167995,0.024155485,-0.0077791074,0.027635315,0.059566364,-0.03211725,-0.036775574,0.042076524,0.0705343,0.039051212,-0.061029352,-0.07195952,-0.06309683,0.02532244,-0.050798856,-0.048740104,0.09880382,0.008061741,0.041255288,-0.038838446,-0.060595807,0.05785416,0.06899958,0.051682338,0.026569843,0.050067585,0.036525115,-0.019209115,-0.07972796,-0.04991802,0.053059526,-0.07069342,-0.04797361,0.014755485,0.015411263,0.048121776,0.028605448,-0.0071852696,-0.10536805,-1.3071451e-33,0.05004099,-0.004008362,0.05732434,-0.02001765,-0.01697211,-0.03380265,-0.070880294,-0.0037392832,0.010127562,-0.09416318,0.10513625,0.014708901,0.084896475,-0.018724801,0.0011738093,-0.0014375574,-0.06836966,0.08844354,0.055403106,-0.05275515,0.0017589999,-0.010703612,0.07593533,0.07464679,0.07083868,-0.033618774,-0.02931841,0.062856406,0.052143402,0.052097097,-0.038668327,0.05839761,-0.0005079551,-0.07246001,-0.14138758,-0.02055382,-0.036411367,-0.034315858,0.010414738,0.1024483,-0.018805353,-0.026483534,0.011044221,0.060080327,-0.0080705155,0.06009828,0.0011239386,0.017989712,-0.033279255,-0.033918075,0.03204172,-0.05168223,-0.042104144,0.02593573,0.07060534,0.09684972,0.041164074,0.043632146,-0.015609703,0.017009163,0.0034812596,0.032732468,0.00091471325,-0.049528528,0.03782,0.080934994,-0.03359771,0.028964631,0.043400194,-0.014974786,0.055924393,0.010114191,0.011333652,-0.039916202,-0.0551261,-0.030948598,-0.03551616,-0.030431557,0.0052548884,-0.038441617,-0.016989755,0.12722422,-0.011371116,-0.009155333,0.04795519,-0.007947198,-0.00791465,0.07876173,-0.0034258927,0.026938738,-0.061424397,-0.084060386,-0.03104241,0.052379824,-0.027553003,-2.7446548e-08,0.061449945,0.032004822,-0.012954211,-0.13666849,-0.055305216,0.02523508,0.033180717,-0.02346456,-0.04396083,-0.020919677,0.01998223,0.015522745,-0.024474408,0.028648185,-0.022244887,0.1038953,-0.05219325,0.026792811,-0.050391164,-0.023681942,-0.016336896,0.003471394,-0.1019699,0.07675747,0.06480753,-0.0326408,-0.014218406,0.07087145,-0.017300058,0.015525286,-0.005836833,-0.04417972,0.004647258,-0.06362993,-0.008558268,0.026624316,-0.074053034,-0.05286816,-0.04135843,-0.047888923,-0.03399348,-0.03526638,-0.0055441335,0.021104584,-0.014247125,-0.0150358165,0.022271903,0.03242484,-0.030525228,0.018674212,0.016164793,-0.046619847,-0.031318836,-0.08264692,-0.13503514,0.034712344,0.004363452,-0.030073961,-0.0045123803,-0.07551324,-0.017298214,0.023161944,0.101216786,-0.022024514 +3.4.11.9,"A Mn2+-dependent, generally membrane-bound enzyme present in both mammalian and bacterial cells. In peptidase family M24 (methionyl aminopeptidase family)",384,1.0,-0.04351608,-0.07912795,-0.06549149,-0.019395642,0.07043262,0.05283831,-0.016908973,0.099093705,0.022848567,0.041320655,0.024952365,-0.024519213,0.034565065,0.07716961,-0.009943223,0.049105447,-0.07778326,-0.057230413,-0.037189968,-0.024917837,0.09766552,0.016751627,-0.07067279,-0.1057453,0.020431334,0.0023807958,0.08198513,-0.07885485,0.0020843772,-0.006944848,-0.04606047,-0.07748518,0.06649183,-0.039313953,0.10640928,0.05525445,0.022224056,-0.021619735,0.030162878,-0.06441506,0.046565756,0.08065395,0.058771215,-0.07046243,0.02901035,0.012097348,0.08542308,-0.022359762,0.03503428,0.014416502,-0.026939744,-0.042128682,-0.012023245,0.034259487,0.038471088,0.050934527,-0.07653094,-0.03391959,0.010968591,0.010292892,-0.007523271,-0.03664207,0.048187014,-0.001419391,-0.018749373,-0.051252186,0.020947874,-0.003539381,0.02500949,0.013681575,0.0004968831,0.012383641,-0.053037215,0.00079940923,0.009278414,0.01778616,0.04552857,-0.03407067,-0.03324004,-0.049076997,-0.037282888,-0.0155405635,0.10577229,0.0142760025,0.029234277,0.046494745,0.06376639,-0.014603041,0.03461175,-0.017633324,-0.0255902,-0.064938225,0.042251,0.040484004,-0.10489703,-0.023570744,0.013375861,0.01995234,-0.016124936,0.031183038,0.019976478,0.036357593,-0.07139942,-0.04863329,0.05079186,0.016142325,0.041555654,0.08167172,0.0020846762,0.04125848,0.09086621,0.07050546,0.022016108,0.047340315,0.05754965,0.0049508456,0.07613755,-0.072326936,0.018551704,0.021954391,0.03181051,0.017806528,0.013745863,0.020704428,-0.01920717,0.09075862,-0.06465289,1.6182862e-33,0.020586427,-0.03366755,0.030533768,0.015567663,0.014435871,0.0045854263,-0.033542555,-0.06259128,0.045011688,-0.050615158,-0.10802792,-0.10853435,-0.0024278257,0.028332021,-0.04586156,-0.013419946,-0.0282052,-0.054278992,0.09736659,0.04788857,-0.081050195,0.08163152,0.0025300686,-0.040437352,0.0834786,-0.04822116,0.06709052,-0.042563546,0.117068574,0.0020608865,-0.0551578,-0.06943688,-0.092623554,-0.012036545,0.014957383,-0.0141730085,-0.019725367,-0.06312673,0.0056217117,-0.010273691,-0.022015119,0.009180956,-0.04028019,-0.043722793,0.058151666,-0.08677702,-0.09312253,0.04096275,-0.041930404,-0.015206164,-0.032772,0.0090488875,0.09284592,-0.010838957,-0.07906977,-0.05053989,0.010070963,-0.0012697823,0.07328801,0.09193918,0.012880761,0.021749139,-0.014522371,0.10350966,0.0685475,0.012970454,-0.029004494,-0.09834797,0.037882395,0.10667514,-0.038695417,-0.0938079,0.06279197,0.030575704,-0.004180696,-0.1399951,-0.021092705,-0.006054261,0.03145359,0.051991515,0.059899524,0.01094018,0.008577377,-0.037745915,-0.09015245,-0.028361935,0.0039259545,-0.109609164,-0.034926556,-0.006906045,0.06493445,0.030531986,-0.05093828,0.023261005,-0.07645802,-2.7460341e-33,0.043978296,-0.017520303,0.0812415,-0.06169521,-0.11901066,0.027222726,-0.016730666,-0.011888604,0.02584316,-0.05024961,0.065293476,-0.026426928,0.0039636022,-0.04063763,0.034928374,-0.018357977,-0.017983306,0.03707611,0.05944102,0.008411453,-0.031573698,0.01205157,0.0117305955,0.04171266,0.034510862,-0.007607583,-0.06719064,0.11437789,-0.03501861,-0.045398742,-0.067380585,0.015918506,-0.041822955,-0.08361268,-0.06378704,-0.026748257,-0.05655852,-0.049103044,0.03734909,-0.016471284,0.029692436,0.0756465,0.043353684,0.08463237,-0.070289746,0.00965146,-0.05270509,0.021942513,-0.010787473,-0.08013462,-0.04884501,-0.08267756,-0.0036255564,-0.032487918,0.044440057,-0.0449019,0.009213831,0.026187629,0.033739034,0.023017127,-0.002388578,-0.0668737,0.023581484,0.0541189,0.039900288,0.074927226,-0.03022816,-0.015112786,0.03612472,0.060926907,-0.0005533857,0.012812207,0.040117845,0.032399952,-0.02073355,-0.011321041,-0.09639048,-0.029684834,0.034235884,-0.034097917,-0.006702994,0.02745799,-0.032258783,-0.041212775,0.00388364,-0.07869235,0.055171113,0.15124185,0.0363802,0.059234545,0.013467333,-0.083173424,-0.034016326,0.013681353,0.011358868,-3.0668538e-08,0.05479069,-0.06120619,0.048798416,-0.08696611,-0.09799807,-0.012729017,-0.0029065132,-0.058852293,0.07495015,-0.0022710222,0.019535026,0.04598451,-0.030710477,0.0082132565,-0.008739308,0.15375634,-0.03754731,0.01694302,-0.011104394,0.034687154,-0.014269007,0.013480785,-0.121646784,0.10503564,0.057677045,-0.00591422,-0.030855028,0.0933346,-0.00017910571,-0.052886344,-0.015969818,0.0011025354,0.02092842,-0.07136593,-0.043789625,0.03628237,-0.028199043,-0.035791017,-0.00851899,0.01897888,0.010400896,0.0016532294,-0.0024087483,-0.018373558,-0.0069780643,-0.01227938,-0.0234161,0.04433651,-0.055776082,-0.045377076,-0.012157033,-0.02000833,0.013228609,-0.08093342,-0.10296479,0.061777018,-0.045746643,-0.060699534,-0.025994651,-0.033927955,0.019667765,0.047771133,0.09860988,0.006893455 +3.4.11.10,"A zinc enzyme. Forms of the enzyme have been isolated from Aeromonas proteolytica, Escherichia coli and Streptococcus thermophilus. Examples are known from peptidase families M17 and M28 (of leucyl aminopeptidase and aminopeptidase Y, respectively)",384,1.0,-0.071948,-0.026391886,-0.09057365,0.009190967,0.10566871,0.061421048,-0.035849676,0.058266915,-0.009565582,0.019163134,0.0087932,-0.049226396,0.023114806,0.07303878,-0.053650368,0.010785291,-0.03262241,-0.033472132,0.005080692,-0.024951102,0.07428902,0.08578562,-0.033363394,-0.0024047203,0.020145446,-0.022907877,0.046036348,0.018697169,0.005695734,0.02732956,-0.08043483,-0.09294445,0.09174299,-0.033002928,0.12454063,-0.0036194217,-0.014757972,0.02908475,0.039014075,-0.010272883,0.026415085,0.10555192,-0.022919629,-0.10529889,-0.02551419,-0.0027695699,0.091415435,-0.0061055035,0.021353327,-0.040040907,-0.068429396,-0.11005596,0.03207175,0.02951022,0.014552579,0.019762287,-0.023223428,-0.10667536,-0.018589819,-0.020498728,-0.014358255,-0.035400458,-0.012598832,-0.040249377,0.0133092385,-0.004647351,-0.027766177,0.03837679,0.0014042186,-0.07591873,-0.08199532,-0.031988025,-0.026415478,0.099187076,-0.060359746,0.04510498,0.05706609,-0.09425691,0.010701217,-0.027707014,0.034718197,-0.039938845,0.025826251,0.06463765,0.055656143,0.05997791,0.0023504004,0.07135116,0.047527105,-0.014353884,-0.019086197,-0.017985543,0.010666731,-0.04363417,-0.070313506,-0.01207528,-0.030194335,-4.0683022e-05,0.079384916,0.01361696,0.045147896,0.012748827,0.094437696,-0.10426166,-0.009515822,0.08845904,0.030919284,0.059480824,0.073658235,0.00966073,-0.050951254,-0.001052573,-0.024908086,-0.035575394,0.02468573,-0.019692672,0.064930245,-0.043972887,-0.09071282,0.017364446,-0.008945871,-0.011998101,0.08532853,0.00050198805,-0.042566586,0.10013236,-0.12091088,6.327048e-33,0.0061305836,0.040864628,0.014257835,-0.008075071,0.058024812,0.038078718,0.008200445,0.0371707,0.052728478,-0.04577866,-0.11333909,-0.08767506,0.021448143,-0.058971554,-0.028123831,-0.023928545,-0.009208405,0.0037209967,-0.004215042,0.028878143,0.0025301266,0.063989654,-0.014538065,-0.006758693,0.08918329,-0.0063103684,0.024312079,-0.06408896,0.057977475,-0.013572649,0.0248429,-0.06006957,-0.13011956,-0.018456042,0.14147405,-0.03833743,-0.020084938,-0.026206,0.008628559,-0.037432205,-0.0012921859,0.014424318,-0.040494513,0.017712899,0.07748248,-0.0371054,-0.119376235,0.110713996,0.049443573,-0.01911382,0.026540507,0.03351276,0.031692427,-0.077650055,-0.10050723,0.019140603,0.010872062,0.056294277,0.09547122,0.029737433,-0.01781733,0.08350913,-0.08545619,0.059794527,0.019752458,0.0057744496,-0.09752655,-0.034376305,-0.026178101,0.09487464,-0.054313406,-0.021176198,-0.010339007,0.020402385,0.00916718,-0.16050918,-0.05746441,-0.033526268,0.051407933,-0.028267058,-0.004645624,-0.0010884937,0.00886598,-0.0022886002,-0.1107656,-0.0554841,0.00440041,-0.0042316495,-0.04940866,0.011161518,0.0025012342,-0.05151432,-0.017032675,0.046500806,-0.046132613,-6.494642e-33,0.031966567,-0.008404421,0.040258195,-0.07897688,-0.044304475,0.03975628,0.009538145,-0.007362995,-0.006928307,-0.052998953,0.092247985,-0.0045018625,0.096137084,-0.0039593163,0.08121051,0.051923245,-0.06815782,0.05837607,0.07649602,-0.037886035,-0.00014062374,0.002103096,-0.0025288025,-0.037995044,0.021402452,0.013653609,-0.021849986,0.1222379,0.07552681,0.028122941,-0.040423777,0.08872266,0.023339842,-0.05445243,-0.12521105,0.01739215,-0.020209359,-0.03248796,0.07706579,-0.022061931,-0.019335162,0.0029262644,0.041314248,0.09040792,-0.006534982,0.07618446,-0.06138759,-0.011579709,0.015309003,-0.027214125,-0.002786111,-0.026959695,-0.07289499,-0.008896697,0.057868045,-0.018269006,-0.00796086,-0.0026080892,-0.045996543,-0.031941466,0.02042403,-0.046161447,-0.016462626,0.10198611,0.04598905,0.043900356,0.024462743,0.030463392,0.004577964,-0.016225182,0.049285065,0.046072908,0.011760001,-0.00810972,-0.008457966,0.016881626,-0.030110013,-0.006765398,-0.021285865,-0.043226518,0.020316035,0.023077214,0.035392907,0.0067082853,-0.00037668587,-0.1255278,0.043022096,0.052020516,-0.009223517,0.046448577,-0.031314835,-0.022062715,0.027660606,0.0408597,0.016856272,-3.85774e-08,0.029157033,-0.051684227,0.09673133,-0.07025046,-0.028008388,-0.017157538,-0.01832492,-0.07883775,0.04780831,-0.032586407,0.027092127,0.024339203,0.0014774426,0.050729424,0.0103518,0.021115834,-0.07468774,0.02920941,-0.010283658,0.078674644,-0.052652348,0.042284135,-0.08126026,0.038953636,0.0009564852,-0.025110317,-0.040522285,0.035429258,-0.03034404,-0.026209937,-0.086378634,0.03309498,0.01986686,-0.08400514,-0.06931785,0.030066574,-0.049866807,-0.0135707455,-0.07016996,-0.036776535,0.07235952,-0.048348233,-0.02669363,-0.02904408,0.01288296,-0.06571853,-0.025980877,-0.0031377976,0.014946654,-0.010971669,0.041921284,-0.024978964,0.03219904,-0.07463101,-0.058012784,0.018414339,-0.029473571,-0.09232351,-0.020337641,-0.045858514,0.018799819,0.003695865,0.13939452,0.047499187 +3.4.11.13,"A secreted enzyme from Clostridium histolyticum, requiring Mn2+ or Co2+. In peptidase family M9.",384,1.0,-0.036890812,-0.011121147,-0.108313,0.019510515,0.0923271,0.0071159885,-0.023180269,0.08812408,-0.02465712,0.035636123,0.051306896,-0.06785237,0.056681138,0.052202675,-0.014103879,-0.031967748,-0.039956465,-0.07765439,0.002047618,-0.016809033,0.11214868,0.0850936,-0.010746498,-0.018397165,0.007983544,0.060023557,0.096658505,-0.06345806,0.012141948,-0.045047935,-0.033312213,-0.061009616,0.05170837,-0.057127982,0.090110384,0.03155231,0.024647294,-0.0069923215,0.06985972,0.023887232,0.015806321,0.048451643,0.055442974,-0.06556797,-0.061788402,0.0010686886,0.048829995,0.025094323,0.014362153,0.05382247,-0.040807888,-0.08561065,-0.022266097,0.01634693,0.040569887,-0.0034785632,-0.06699153,-0.05791808,0.0058099404,-0.005053016,-0.0062477784,-0.030424042,0.039906964,0.025933154,0.032335345,-0.087779045,0.0092688445,-0.043317217,0.007971894,-0.01521124,0.053765196,-0.049119424,-0.057536103,-0.021302436,0.012281247,0.021610737,0.023118414,-0.09350237,-0.014742826,0.0016415496,-0.048106603,0.013092557,0.08663572,0.03662006,0.013340898,0.06791894,0.104944006,0.011176264,0.024036532,-0.026719905,0.0063021476,-0.03924864,0.04928453,-0.015933959,-0.060340058,0.023930917,0.005421825,0.0039428654,-0.04398186,0.012350228,0.034917094,0.030935308,-0.06978935,-0.07036915,-0.005187611,-0.010479677,0.033064164,0.10186666,0.04931858,0.019331783,0.041183677,0.06059813,0.034899455,-0.017501304,0.060191885,0.04260157,0.117878355,-0.04439153,-0.034958422,0.054656424,0.053717,0.018979011,-0.02788243,0.020003835,-0.051901333,0.09285366,-0.063595675,2.8299106e-33,0.007264174,0.011852104,0.031550106,0.006317006,-0.022811186,0.043447267,-0.068359934,-0.038950652,0.062713854,-0.060778543,-0.09254877,-0.10565573,-0.011592677,0.049214784,-0.08192175,-0.043635976,-0.036205996,-0.033172645,0.13036582,-0.00498415,-0.018952437,0.10043276,0.01428653,-0.025674615,0.06805477,0.06675045,0.07229442,-0.032506306,0.06494947,-0.023701545,0.0017000156,-0.041247334,-0.06247013,-0.041347906,0.035507742,-0.0030077023,-0.026491005,-0.080937006,-0.063951656,0.005865392,-0.014826169,0.0054832315,-0.0838274,-0.025608718,0.0382534,-0.086991265,-0.0652874,0.09785356,-0.003265271,0.013628635,0.00017836163,0.04241776,0.09742496,-0.059030935,-0.08655084,0.028721647,0.051047113,0.01932886,0.099013664,0.049413316,0.054950826,0.094210595,0.010132968,0.094106466,-0.007931194,-0.07153176,-0.056210198,-0.067788884,0.06645425,0.079558864,-0.07050429,-0.100885935,-0.020409042,0.007262875,0.012694569,-0.10764975,-0.042040847,-0.02376306,0.013521473,0.009685674,0.0013170288,-0.03271045,0.04568354,0.0132529475,-0.056227393,-0.015324609,-0.10428816,-0.0708944,-0.06081759,0.044289608,0.04153316,-0.0045696707,-0.03611775,0.025218543,-0.08599134,-4.7933875e-33,0.04760889,-0.04733677,0.055967845,-0.047457464,-0.07603602,0.02495487,-0.053418014,-0.026002124,0.009622156,-0.03704932,0.041493133,-0.017868962,0.05332475,-0.0714346,0.040927086,0.028703112,0.04464879,0.101808675,0.0333782,0.017315542,-0.04734254,0.0641706,-0.012851254,0.0024642933,0.03238702,0.054403685,-0.0039019715,0.061586965,0.029393619,0.0034087976,-0.03948177,0.034665808,-0.03943136,-0.06692186,-0.09449541,0.017649507,-0.06963708,-0.029183779,0.016579112,-0.048302043,-0.008368279,0.04846388,0.0665721,0.114401504,-0.045869444,-0.032126606,-0.036672935,0.009782089,0.0022522383,-0.0031231672,-0.065385714,-0.042415626,-0.026318407,-0.058188647,0.055814564,-0.050632,-0.058584906,-0.005012395,0.043212716,-0.025256908,-0.0163971,-0.009531632,-0.033474144,0.06755148,0.036289707,0.044076294,-0.054961503,-0.033846833,0.043479607,-0.0063666846,0.030131962,0.017595138,0.025642311,-0.003953776,-0.020754587,0.032801814,-0.09424806,0.00017552302,0.025875218,-0.021544613,-0.02445832,-0.022018705,0.010316912,-0.05714981,0.03579578,-0.12959926,0.019353876,0.08225822,0.022133736,0.03617269,-0.030073041,-0.061328426,0.006225547,0.010329104,0.04186747,-2.9144022e-08,0.04236425,-0.107667185,0.08933562,-0.07360272,-0.045903653,-0.007049794,-0.02355308,-0.068568386,0.038004756,0.010237773,0.046148986,0.04319251,0.03429362,0.026785186,0.0126764355,0.09076955,-0.05301266,0.015649272,-0.008817907,-0.02013089,-0.11505143,-0.04765291,-0.06462788,0.096306644,0.040090133,0.03150183,0.018241884,0.09177404,0.015482717,-0.0060662273,0.005107197,2.011003e-05,-0.01194006,-0.07700552,-0.07506302,0.06711953,-0.011259119,0.005154107,0.018609235,-0.039172437,-0.0066702794,-0.014750488,-0.045419414,-0.00803502,-0.0705971,-0.046810668,-0.034497444,0.044359833,-0.07413873,-0.09323845,0.024116585,-0.05711919,-0.010291434,-0.03317507,-0.03449202,0.014429704,0.018651139,-0.09042364,-0.034268744,-0.049897667,0.035235267,0.053496096,0.1502513,-0.009544089 +3.4.11.14,"A puromycin-sensitive, Co2+-activated zinc-sialoglycoprotein that is generally cytosolic. Multiple forms are widely distributed in mammalian tissues and body fluids. In peptidase family M1 (membrane alanyl aminopeptidase family)",384,0.99999994,-0.08926966,-0.0481994,-0.115902536,-0.024170114,0.0053300615,0.061118655,0.09120472,0.102356195,0.040116563,0.020317618,0.039697707,-0.011246173,0.052533858,0.073785625,-0.002722943,-0.00970819,-0.055996668,0.0012859612,0.038816415,-0.09344296,0.025114434,0.05582764,-0.05791059,-0.0031470149,-0.05048443,-0.01254301,0.015009054,-0.021531634,-0.0016424746,-0.027024787,-0.037006296,-0.07999367,0.08590558,0.0019371631,0.066276565,0.0023212195,-0.023191964,-0.0013870299,0.043876022,-0.04659646,0.040565614,0.055944473,-0.05639991,-0.027881896,0.015283452,-0.009998597,0.05568562,0.046408873,-0.00033268397,0.022234466,-0.03507581,-0.06387929,0.010186326,-0.0001865158,0.033153437,0.060047153,-0.15521945,-0.043188617,0.054815322,-0.038250536,0.028040966,-0.06969076,0.00893418,0.0099735735,-0.023205873,-0.051345762,0.05323757,-0.02984556,0.045147773,0.015971003,0.011497717,0.006908152,-0.044412345,0.057045624,-0.024793282,0.031598587,-0.01271026,-0.10676797,-0.06625349,0.00907294,0.03021338,0.0062707276,0.060783107,0.06733711,0.060846128,0.038097154,0.04071605,0.030075142,-0.09134374,-0.0020703354,0.0020274583,-0.0689735,0.104863055,0.036261838,-0.13385439,-0.0014022818,0.05513103,-0.06494725,0.050799645,0.01847714,0.04111499,0.028585183,0.058194883,-0.07568388,0.069130234,0.04488305,0.018831726,0.03153648,0.061739597,0.029473944,-0.07767493,-0.01023182,-0.0737558,-0.0053853155,0.009647407,0.04444292,0.06499899,-0.003497491,0.03735118,0.022880472,0.023576178,0.050047845,-0.054805372,0.011366122,-0.023931196,0.07000904,-0.054085445,2.5757998e-33,-0.056396253,0.067648254,0.03251496,0.08565985,-0.0018647583,0.03768906,-0.044480722,-0.021966808,0.04881302,-0.041793212,-0.09895487,-0.044598054,-0.014596928,0.091590494,-0.06459863,-0.04251962,-0.08795294,0.0062050275,0.09314883,-0.011179347,-0.036202867,0.11394063,-0.020801764,-0.055673767,0.04644403,-0.016036676,-0.0072448803,0.040744632,0.08083287,-0.0090716705,-0.057527043,-0.0020484063,-0.038597237,-0.052790496,0.07782253,-0.04969487,-0.0019550696,-0.06723349,0.04933915,0.01115498,-0.01352799,-0.06765298,-0.08408686,0.012510099,0.038136598,-0.06076845,-0.12255477,0.070529416,-0.04623635,-0.048676252,0.005094519,0.0018033632,0.024019558,-0.026892575,-0.08495913,0.0047557964,-0.0028550362,0.016324364,0.037152357,0.05995377,0.0738445,0.0056705447,-0.0142487995,0.023519432,0.014989435,0.013384958,-0.11174962,-0.068469554,0.0004822203,0.09826425,-0.015884994,-0.008624501,0.027766483,-0.005241184,0.079016626,-0.100617416,-0.034224987,0.06856146,0.030738726,0.06990146,-0.05101399,0.02351701,0.010689463,0.029632524,-0.056191973,-0.037791055,0.03928318,-0.03186541,-0.067142464,0.0063217045,-0.029225802,-0.014091187,-0.027332135,0.010870237,-0.046725396,-4.3905526e-33,0.014302339,-0.033108402,0.082365066,-0.030646512,-0.0072968015,0.019671256,0.02384548,-0.034823805,0.06442526,0.035194755,0.069803745,-0.041854117,0.0007886835,-0.07221996,0.06411019,0.04200856,-0.046739068,0.05772899,-0.03569239,0.015167786,-0.08294442,-0.031866614,0.017891226,0.06482381,0.02908355,0.009514249,-0.092408344,-0.012512316,0.033163834,0.07684258,-0.042232405,0.027100097,-0.04083547,-0.06694786,-0.072965,0.01855745,-0.017103652,-0.013179568,-0.03471477,-0.0739173,-0.014927141,0.022641605,0.026616132,0.091507494,0.05231689,0.11363414,0.0021433847,0.009424513,-0.070323005,0.019254038,-0.020573933,-0.005456165,-0.019859588,0.034256317,0.09160442,0.010649324,-0.026220718,-0.014251054,0.01825039,-0.006043608,-0.03888179,-0.04912138,-0.092745975,0.061318256,0.052722637,-0.03135493,-0.053030062,-0.008199633,0.049757138,-0.01007501,0.033760242,0.027627116,-0.012768223,-0.0645392,-0.051906846,0.033834137,-0.078398995,-0.10402168,-0.04063543,-0.02402594,-0.022601195,0.002112524,-0.06598584,0.03543086,-0.028703192,-0.07092333,0.015471366,0.04745476,0.010629969,0.07143062,-0.02281235,-0.00757748,-0.054006156,0.026456987,-0.040179454,-3.659947e-08,0.07914183,-0.016094537,-0.007781747,-0.11551593,-0.06847716,-0.014795502,-0.061727084,-0.009760575,0.05834786,-0.033741318,0.019631222,0.047172055,0.07225203,0.014576523,-0.021847,0.14135547,-0.051477347,0.019481959,0.03457156,0.029517135,-0.081342936,0.040968053,-0.08298907,0.088416114,0.04977882,-0.017506788,0.051308822,0.07839653,-0.043226447,-0.005192895,0.058333755,-0.019794123,-0.043850575,-0.01841289,0.025466144,0.05291915,0.009878559,-0.028663285,-0.016217684,0.017796043,0.014935086,-0.0013360447,-0.07737087,0.0075495145,-0.03862875,-0.025112357,-0.011767153,0.035055153,-0.009647432,-0.018111402,-0.05485477,0.00080005213,-0.03270683,-0.065623924,-0.04354811,0.04087842,-0.020929953,-0.103018254,0.015163582,-0.07393845,0.013386594,0.07644023,0.1959361,0.013385952 +3.4.11.15,"Requires Co2+; inhibited by Zn2+ and Mn2+. An enzyme best known from Saccharomyces cerevisiae that hydrolyses Lys-NHPhNO2 and, more slowly, Arg-NHPhNO2. Type example of peptidase family M28",384,1.0,-0.040885653,-0.042301133,-0.0746766,-0.0300916,0.12983108,0.024303706,-0.058803365,0.04894301,0.00012013632,0.03071225,0.0021841775,0.0037701968,-0.04734603,0.062348854,-0.06156515,0.0414112,-0.06014249,-0.037906554,0.025123267,-0.09127644,0.09696665,0.058835637,-0.019874675,0.013615771,-0.002945167,-0.03261945,0.06278609,-0.03612509,0.054176692,-0.0731403,-0.013167471,-0.027583662,0.08019224,-0.04745593,0.026292244,0.080846645,0.05530654,0.017278962,0.03262317,-0.002791325,0.027084276,-0.0006400273,0.0053559486,-0.06780499,0.027745334,-0.0011756206,0.040802196,0.012745596,0.012169201,-0.026443249,-0.08688907,-0.07611382,-0.03143626,-0.008342479,-0.009665283,0.03474102,-0.08519081,-0.002140609,0.0411928,-0.013078329,-0.011686844,-0.008856214,0.008117118,0.009511777,0.04333447,-0.027646385,0.017546155,0.0016532202,0.0026537448,0.051833373,0.0011602395,-0.034263466,-0.13093257,0.019893339,-0.042674243,0.03386652,0.036443517,-0.104002066,-0.0029127821,-0.014762987,-0.020429727,0.023036167,0.13039353,0.05827297,0.06277214,0.023331994,0.016138516,0.027584566,0.06059529,-0.011417897,0.0071189203,-0.05845553,0.07778212,0.037162613,-0.014183458,0.021714635,0.032845788,-0.020046948,-0.020266607,0.026722569,0.050727554,0.030987399,-0.035463046,-0.017277844,0.044361692,0.07115571,0.07971908,0.07318449,0.06916448,0.07406326,-0.008738266,0.023768885,-0.014524373,-0.05893049,-0.00088872464,-0.00965064,0.050812263,-0.047798693,-0.048697267,-0.0019810721,0.03847914,0.05282253,-0.016928649,0.004080094,-0.07540204,0.10834745,-0.07782868,6.0613745e-33,0.004696254,0.016263679,-0.011547223,0.013482374,-0.011226273,0.018293833,-0.08511637,-0.016583094,0.03523992,-0.07525949,-0.07227485,-0.042005986,-0.020073844,0.03702417,-0.06100191,-0.041011125,0.011522102,0.0067827413,0.04892504,0.045114286,-0.0041894703,0.006570354,-0.065992974,-0.025370972,0.06670574,0.050913524,0.11137509,-0.013995036,0.06148492,-0.031987716,-0.029224934,-0.08253487,-0.098547794,0.0007860486,0.044218145,-0.03628667,-0.024952494,-0.0563592,-0.0003648668,-0.002554586,-0.0268066,0.052175764,-0.076484665,-0.04465987,0.04973107,-0.07202672,-0.050379377,0.055932418,-0.022816705,0.0549815,-0.01208774,0.037592895,0.017366873,0.045607433,-0.068867125,0.010700897,0.019826349,0.01503777,0.0803484,0.033456955,-0.025820531,0.056557514,0.020999802,0.08951728,0.0045052287,0.01801819,-0.07471022,-0.09279371,0.023903789,0.06697784,-0.09562203,-0.008476001,0.052750494,0.01545507,0.041356456,-0.16508293,-0.042381886,-0.00940361,-0.016591927,0.06937604,0.017557476,-0.083501935,0.041707914,-0.02678051,-0.061555054,-0.048938017,-0.02363318,-0.03922411,-0.061826028,-0.0022378748,-0.003957025,-0.04278746,0.021299904,0.066836394,-0.028379673,-6.205864e-33,0.0790177,-0.03000702,0.106154464,-0.07917877,-0.060979597,0.067259826,0.0058075343,-0.12248174,-0.014696221,-0.055249583,0.034907967,-0.030095499,0.0582102,-0.029378196,0.04480922,-0.011035327,0.016515417,0.068579465,0.04802219,-0.020290943,-0.03632933,0.0812378,-0.007995828,0.037866995,0.055733938,-0.001007341,-0.059627198,0.09586461,-0.006632948,-0.01466141,-0.07126968,0.04121418,-0.030350331,-0.09591,-0.061221622,0.06422091,-0.03462423,0.012223331,-0.06479641,-0.010629173,0.054847416,0.048258953,0.0013028234,0.0927418,-0.052489173,0.060505405,-0.05328089,-0.0029567627,0.028442074,-0.01020976,0.007811823,-0.034653552,-0.077779494,-0.00061914464,0.09072905,-0.07541468,-0.0121966405,0.06540474,-0.021991154,0.017983936,-0.023160612,-0.057327427,-0.030956253,0.04037396,0.071926706,0.01712982,-0.0868689,0.009512626,0.029197251,0.04754639,0.067066185,0.089235805,0.095814936,0.06536944,-0.030884001,0.039032895,-0.060137864,-0.065370284,-0.0029154662,-0.1306519,0.0025963753,-0.017259449,0.016976561,-0.018908855,-0.03998805,-0.08105791,0.032560073,0.013841096,-0.039761823,0.068767205,0.037901893,-0.06703458,-0.020456132,0.035143264,0.0002009038,-3.673627e-08,0.057659585,-0.07571578,0.073375285,-0.08969173,-0.052816473,0.0009693213,0.02034537,-0.015811956,0.041598078,-0.020319307,0.0013455558,0.07206983,0.060777627,0.059988216,0.07300766,0.023630999,-0.017278604,0.052520566,-0.034555685,0.030815473,-0.054316938,-0.0005916481,-0.10596906,0.07486121,0.02624603,-0.049470406,0.064344004,0.06386415,0.032084815,-0.030039335,-0.025139596,0.04224404,-0.014261444,-0.05893802,-0.008649468,0.08120227,-0.048244145,-0.010649483,-0.046150137,-0.033386234,-0.039767183,0.016472312,-0.044966433,-0.026897244,-0.0010836805,-0.050546266,0.00030862418,-0.029260784,-0.0029355127,-0.018088032,0.06336833,-0.030474387,0.011183646,-0.091987856,-0.076772064,0.03232159,0.0046327305,-0.073641196,0.0057095517,-0.087587625,0.08286685,-0.0196485,0.1668063,-0.03379928 +3.4.11.16,"A glycoprotein containing Zn2+, from renal and intestinal brush border membranes. In peptidase family M9.",384,1.0,-0.071128026,-0.06327104,-0.054043397,-0.01758709,0.030237947,-0.012821384,0.049759757,0.11359899,0.000461989,-0.033668984,0.030376758,0.03417115,-0.007946614,0.07266538,-0.07645537,-0.04859813,0.008439289,-0.01106585,-0.012696771,-0.06279054,0.04203019,0.09742702,0.0121014565,-0.023834694,-0.030232746,-0.05993581,0.03136876,-0.055821046,0.06803835,-0.0026056462,-0.022123441,-0.054557934,0.029505335,-0.013373059,0.032387674,-0.0625098,0.06694503,-0.0068193297,0.019835236,-0.031675458,0.09289623,0.047403336,-0.040007878,-0.05969935,0.038227018,0.020181539,0.078156136,0.031262472,0.02829036,0.12794845,-0.08436599,-0.07915046,-0.0050339303,0.055157874,0.05128486,0.051884897,-0.103808425,-0.048693467,0.0357228,0.012227594,0.0052637896,0.020152666,0.03920775,-0.015495555,-0.020374654,-0.040247858,0.02781212,0.02566962,-0.020073881,-0.029925136,0.027231852,-0.0029811861,-0.03328529,-0.022840038,-0.04945527,0.04887923,0.011093849,-0.05941493,-0.07544444,0.019874917,0.0434203,0.030023072,0.13109736,0.074750885,-0.014998105,0.040955458,0.054289803,0.010966487,-0.033130925,-0.043741696,0.05267877,-0.05323386,0.08750439,0.018270144,-0.04230618,-0.04068932,0.030591546,-0.044711217,0.003231254,0.023248743,0.0037932433,0.013398793,0.07867537,-0.07911779,0.0027460991,0.1260487,0.0063324436,0.031198459,0.0816259,0.029781442,-0.02370968,-0.0029568095,0.0013603785,-0.0716721,5.6844623e-05,-0.02542924,0.048430476,-0.01277461,-0.008517232,0.046117507,0.01392933,0.056683093,-0.012334551,0.015146444,-0.006805097,0.08587824,-0.055531714,8.223115e-34,-0.06607243,0.0075394246,0.037483193,0.041375525,-0.026625259,0.055873685,0.0056587993,-0.005502652,0.031131476,-0.07715417,-0.1400341,-0.10237837,-0.033439353,0.052762285,-0.0951318,0.039179593,-0.0557303,-0.067709446,0.10228095,0.013176927,0.016195279,0.033572484,-0.0100390455,-0.10775224,0.11193365,-0.0035063003,0.032338955,-0.014733752,0.068139724,-0.021325545,0.0040076044,-0.08187353,-0.075963765,-0.00069636665,0.014073245,-0.020061921,0.045586687,-0.08076431,-0.0007779904,0.0030700958,-0.041134283,-0.04811879,-0.045636933,-0.035549294,0.053167768,-0.037641797,-0.108072646,0.05338959,-0.007999589,0.01576366,0.027119068,-0.019413054,0.028952142,0.03059082,-0.10988403,-0.03221902,-0.013174158,0.014380976,0.024605334,0.07380522,0.05445178,0.0612034,-0.06582307,0.045710173,0.024332011,0.050643425,-0.096520916,0.02424694,0.038514152,0.012597365,-0.064696305,-0.031152451,0.086561754,0.06185069,0.034007113,-0.18311006,-0.00094365526,0.05069287,0.055328764,0.057834655,-0.036894776,0.043687887,0.018174663,0.050581366,-0.024830451,-0.024865393,0.00020929334,-0.058593195,-0.04333583,0.020620717,0.011455299,-0.0010373365,-0.06427081,0.092170104,-0.10007471,-2.050799e-33,0.098658666,-0.04596725,0.08082887,0.011342782,-0.04357667,0.022452366,0.012530604,0.012909181,0.025203058,-0.0137252305,0.052953105,0.004255123,0.06254529,-0.07119103,0.06850206,0.018666103,-0.04351284,0.04278906,0.010776796,-0.01903785,-0.041167844,-0.041700136,0.013692428,-0.032651797,-0.022285404,0.009376034,0.035694707,0.011763131,0.04387258,0.028567318,-0.03952735,0.0114702815,-0.122177795,-0.1060693,-0.08793801,-0.030050738,-0.06108061,-0.045994204,-0.04368984,-0.11630574,-0.017445253,0.0006304995,0.04245457,0.07173644,-0.006869749,0.049796496,0.028976437,-0.020595666,-0.09079842,-0.021610158,0.0145924175,-0.013251648,-0.029893832,0.083365485,0.08342575,-0.0066349227,0.044617902,0.027824689,0.050990865,0.070120305,0.022654105,0.046619616,-0.04371367,-0.011000472,0.06317398,-0.007089715,-0.0147785535,0.0079375645,0.040423993,0.0063568936,0.092016116,0.012205245,0.051714513,0.018335486,-0.03177884,0.09852405,-0.07627876,-0.066378534,-0.008277573,-0.031879995,0.004253211,-0.041467596,-0.01491449,0.061190724,0.05091185,-0.040864345,0.005505321,0.11578961,0.049098894,0.004961603,0.016046837,-0.010998032,-0.027464133,0.0067532663,0.035164703,-2.7271575e-08,0.054938037,-0.08977739,0.023329817,-0.10656316,-0.1065157,-0.035939336,-0.0052939043,0.02587652,-0.049682587,0.020190895,0.043139387,0.01947802,-0.057992514,-0.031531025,-0.049575623,0.105919205,-0.0428488,0.0045286724,0.017194118,0.027032886,-0.10094194,-0.0029565413,-0.07846656,0.06459854,0.016080236,-0.080737546,0.0005937886,0.08851638,-0.050819885,-0.042506523,0.0120633235,0.005317982,-0.036707018,-0.058522243,-0.008787668,-0.0018772766,0.020864563,-0.02932218,0.016782027,-0.058103755,0.006939808,-0.03948421,0.057195485,-0.06800226,-0.020357843,-0.036001552,0.0025756296,0.028847968,-0.00024541275,0.0015697416,-0.011050985,0.004105525,-0.0068531884,-0.069175385,-0.0809857,-0.033007428,-0.009054893,-0.053196605,0.036014304,0.014826521,-0.015322723,0.02871567,0.096160494,0.058257163 +3.4.11.17,From Trichosporon cutaneum. Also acts on L-tryptophanamide. Requires Mn2+,384,1.0,-0.035133157,-0.099577166,-0.1163582,-0.022848153,0.07243519,-0.009421355,0.0023473897,0.07052463,-0.00045422238,0.010347935,0.13742481,-0.09176595,-0.045891706,0.077020355,-0.044757396,0.053931873,-0.004910257,-0.022926887,0.009126081,0.0142050255,0.06691785,0.046824094,0.002279763,-0.026408814,-0.033361424,0.080900125,0.06757466,-0.03187425,0.038563583,-0.057559583,0.002894349,0.05855834,0.0018437438,-0.10089604,0.034204878,0.05000474,-0.10575945,0.027693113,0.02411724,0.014517355,0.012809257,-0.05035705,0.06582495,-0.059838854,0.01461904,-0.02553197,0.023054164,0.03766638,0.03757306,0.08813415,-0.03328879,-0.031230785,0.0031724575,0.04412502,-0.024487177,-0.035286173,-0.13836074,0.07264917,0.0052231555,0.057144243,-0.014069092,0.00012390639,-0.048493482,0.011483867,0.03821992,0.011127018,0.0166914,-0.07827534,0.020240035,-0.024988981,0.036994003,-0.044895124,0.010750863,0.02563036,-0.026113499,0.028359527,0.07673695,-0.05786094,0.027220123,-0.022294996,-0.035360307,0.03546655,0.06862484,0.0731375,0.06915526,0.06330402,-0.018358234,0.10396163,0.03835301,-0.035111766,0.07347757,0.05872308,0.0014399982,0.05657081,-0.066519976,0.059441123,-0.06684098,0.0006136322,-0.058729287,0.011022384,1.897346e-05,0.006155823,-0.1328974,-0.09569115,-0.0387601,-0.016687393,0.053422164,0.038805664,0.025220715,-0.008788796,0.013977614,0.06973522,0.0039211935,0.008153449,-0.008144338,0.0075307307,0.124712385,-0.062460233,-0.005696455,0.0002747233,0.04433216,-0.052560817,-0.06032485,-0.007913205,-0.041356403,0.05842593,-0.029859789,4.0355544e-33,0.084993504,0.040246576,-0.009715463,0.023417223,0.0063519236,0.008737434,-0.023675583,-0.09356822,-0.03374807,-0.039955385,-0.045835316,-0.11225721,-0.013570103,0.05402182,-0.059721645,-0.07101591,0.003210797,-0.035186663,0.05579624,-0.014039127,-0.0069848415,0.1304962,-0.03439861,0.022650128,-0.006587999,0.1058819,0.06289721,-0.04675265,0.075835735,-0.0074340124,0.0055770096,-0.020170808,-0.07188064,-0.003990851,0.043753438,0.06764095,-0.0678563,-0.026494706,-0.0393734,-0.010294381,-0.013713046,0.054810833,-0.07775823,0.04074312,0.06341749,-0.094372414,-0.09235829,0.0775417,0.013343318,0.03328278,0.023518903,0.00045718174,0.047387935,0.026191192,-0.11291145,-0.02999044,-0.008145147,0.018728955,0.089195564,0.03721427,-0.025053188,0.021562623,0.0056150756,0.06817476,0.01353485,-0.043549128,-0.088740304,-0.11311262,-0.043230418,-0.07256312,-0.0209761,-0.0919112,0.08459757,0.008015819,0.032363467,-0.0492356,-0.04018834,-0.010014328,0.01179938,-0.030467875,0.033094913,-0.07707902,0.033751465,-0.012156939,-0.07594555,0.01972223,-0.037640866,-0.068959914,-0.0055669737,-0.050998975,0.05632069,-0.003182733,-0.015461107,-0.00019517561,0.0056478623,-3.3978612e-33,-0.03209701,-0.0325186,0.039304372,-0.032273065,-0.029016806,0.022459311,-0.03893601,-0.09070252,0.022533748,-0.034058552,0.0944026,-0.010105612,-0.019327404,-0.023053247,-0.0610648,0.034392815,0.09526153,0.018908866,0.039189197,-0.051845826,0.013752152,0.08955132,0.013830214,0.042249084,0.035323247,0.075806834,0.025113037,0.027666193,0.045995228,0.034842864,-0.04725846,-0.031054698,-0.07130287,-0.08280951,0.007399716,0.058575746,-0.0038283488,0.0065665077,-0.048759848,-0.062479552,-0.0053152675,-0.060350433,0.038461134,0.06132221,-0.061673556,-0.015189702,-0.02511389,-0.031361084,-0.04956312,0.014025297,-0.009684689,-0.018173855,-0.027189316,0.014911352,0.05591265,-0.003573694,0.0027501422,-0.056662053,0.0024249954,-0.015783966,-0.019274183,-0.0030469808,-0.065150276,0.003225981,0.093398236,0.11192762,0.023830077,0.070774406,0.04853724,-0.020333461,0.039145343,0.07804923,0.0911986,0.029503416,-0.06084434,-0.107579984,0.019820448,-0.051476046,0.03074705,-0.049059745,0.05344341,-0.071556255,0.00024065548,-0.0073128287,0.03434328,-0.090675786,0.023140637,0.07169214,-0.06546736,0.014176824,-0.011178583,-0.022150692,0.002826404,0.05793852,0.06250565,-2.4321789e-08,0.011558112,-0.08504281,-0.0034399086,-0.103155516,-0.0032018356,-0.004496177,0.056992322,-0.00045046463,0.01015532,-0.056460414,0.0310067,0.072234705,0.08043138,0.019890063,0.059099246,-0.016494023,0.036981482,0.10450529,-0.03674254,-0.0558153,-0.044197004,-0.036032923,0.00923758,-0.046403274,-0.008543443,0.031762548,0.052327152,0.06837043,0.051945306,-0.003968249,-0.053072862,0.023642987,0.05648387,-0.04820192,-0.014994161,0.12933107,-0.030875377,-0.0075583803,-0.01887399,-0.037908766,-0.096415624,0.041674152,-0.008174886,0.048428405,-0.023696076,-0.09929452,-0.026853386,0.030834695,0.048425883,0.00068932836,0.031727947,-0.020815564,0.033937726,-0.05288358,-0.11200571,-0.0049962397,0.0045540445,0.0014564433,0.026148899,-0.061246756,0.031418942,-0.009871092,0.029314838,0.026932003 +3.4.11.18,"This membrane-bound enzyme, which is present in both prokaryotes and eukaryotes, releases the initiator methionine from nascent peptides. The activity is dependent on the identity of the second, third and fourth amino acid residues of the target protein, but in general the enzyme acts only when the penultimate residue is small and uncharged (e.g. Gly, Ala, Cys, Ser, Thr, and Val). In peptidase family M24.",384,1.0,-0.06438927,-0.05167055,-0.09832687,-0.015379654,0.064640276,0.04112918,-0.018590143,0.10358434,0.07447193,0.014767664,0.0210917,-0.05220071,-0.02154726,0.07683224,-0.025863236,0.03530872,-0.0520259,-0.03240798,-0.02272678,-0.06459747,0.0328475,0.027966175,-0.053250488,-0.0166556,-0.023271248,-0.041332804,0.04794313,-0.0331597,0.052460227,-0.0326655,-0.0322509,-0.102884,0.05917957,0.004141925,0.0415121,0.11026598,-0.03866436,-0.021380212,0.04646171,-0.016666112,0.14250991,0.010807193,0.0041321926,-0.068668455,0.07022957,-0.002256494,0.0045229737,0.06915922,0.057492442,-0.063155636,-0.056881085,-0.04823331,-0.004971652,0.061984472,-0.057068884,0.04409117,-0.01299451,-0.031088717,0.035954453,0.008143717,-0.024461221,0.0027849856,0.036183506,-0.034055665,0.0335857,-0.12922731,0.031908643,0.005176168,0.028150566,0.027262738,0.03493808,-0.011107812,-0.031221386,0.0075477157,0.00984031,-0.028116558,-0.055811618,-0.039788876,-0.02042693,-0.03328649,0.066641636,-0.0048959614,0.05838915,0.028772878,0.02387312,0.02155348,0.04373853,-0.050710157,0.09541845,-0.0045196465,-0.02169584,-0.07211212,-0.031221796,-0.024180237,-0.11591712,-0.06960477,0.036990494,0.020008748,-0.02125127,0.066541135,0.04136185,0.018520279,-0.11140479,-0.038521174,-0.056844044,0.017161824,0.050288323,0.04264311,0.012452254,0.042305622,0.05578576,-0.055693578,0.08104219,-0.015075357,0.0061331135,0.09741791,0.019180853,-0.011247714,0.03566263,0.032728776,0.009282477,-0.02143245,0.07558246,0.02389503,-0.046772998,0.070248514,-0.10219077,8.271377e-34,0.03725956,-0.018738119,0.027590359,0.024405798,-0.018725412,-0.041974023,-0.07075082,-0.05849913,-0.029674096,-0.0960458,-0.07918482,-0.06674588,-0.012571025,-0.010792722,-0.0468185,-0.04080085,-0.0144400215,0.01800706,0.03745415,0.043707382,-0.04796793,0.026392324,-0.0046957606,-0.017646361,0.07060542,-0.01601832,-0.01488557,-0.018560758,0.06449436,0.018188694,-0.05087108,0.0060217516,-0.1261729,0.03884953,-0.0015916902,0.008307502,-0.039968323,-0.06906465,0.032149058,0.014660553,-0.028448341,-0.014682933,-0.033468574,-0.05946531,0.04912131,-0.059196815,-0.051918436,0.104718156,-0.003208879,-0.013458369,0.036478788,-0.06415513,0.09860802,-0.024977384,-0.1304242,-0.00036876576,-0.02160195,-0.09196645,0.0860368,0.102946915,0.008719055,-0.02634301,-0.077617764,0.08843278,0.016356878,0.02458264,-0.042114094,-0.05021526,0.057005998,0.12853926,-0.070036285,-0.008078168,0.07885245,0.08368814,-0.003284774,-0.06008705,-0.03668603,0.027923452,0.011013052,0.04023524,0.07592881,-0.009016874,0.01837024,0.020906331,-0.028060304,-0.027471827,0.032830548,-0.069599845,-0.046708316,0.017662797,0.043755908,-0.031921413,-0.043348208,0.047695566,-0.049452357,-1.3900073e-33,0.07170601,-0.031882733,0.039405495,-0.03703967,-0.08537531,0.04322174,-0.008082715,-0.019228784,0.039766595,-0.036716912,0.056942694,-0.05343326,0.022992466,-0.005471743,0.069387205,0.008945784,-0.033583246,0.041846085,-0.015903136,-0.028798949,-0.007765436,-0.051156957,0.03041036,0.018929651,0.021262381,-0.022806378,0.004770633,0.08587845,-0.004698067,0.024429489,-0.07540524,0.009177424,-0.07581355,-0.010833687,-0.06976962,0.053550556,-0.034386862,-0.013306973,0.04132735,-0.0018169594,0.0366862,0.10173863,0.04208755,0.10281742,-0.0061253584,0.04919929,0.0011942169,0.07817534,-0.033415157,-0.13609363,0.04231972,-0.09858868,0.052815706,-0.0026594494,0.017294291,0.049658928,0.018974328,0.048856564,-0.027104119,0.010000376,0.0052139806,-0.0650234,-0.013832698,0.027879447,0.032975197,0.027461575,-0.0012024014,0.021035906,0.013528768,0.0015929799,0.05009966,-0.002907277,0.047886495,0.037614893,-0.025706816,0.041592088,-0.117715,-0.05752123,0.032580346,-0.083470635,-0.070228525,-0.0245757,-0.02622945,-0.05742822,0.0062562767,-0.057573672,0.0766402,0.08946234,0.022071965,0.10433595,-0.039447535,0.02715978,0.034963813,0.037367452,0.02166018,-4.6199318e-08,0.09731257,-0.06376831,0.029827578,-0.030523816,-0.0697479,0.0015730088,0.029672822,-0.06304809,0.034993276,-0.0055867466,-0.01669765,0.065680936,0.0030470318,0.006489708,0.006007892,0.14699918,-0.010653514,0.049878974,-0.03884716,-0.009907279,-0.037921354,0.018472925,-0.06642312,-0.0066090566,0.006094141,-0.06213073,-0.002378768,0.12010019,-0.07007761,-0.05599681,0.0073721414,-0.0059504174,-0.034393925,-0.03987859,-0.0268093,0.06350562,-0.06951626,-0.045802746,0.0015187027,-0.00027210626,0.069122,0.0038489178,-0.037028976,-0.019258799,-0.038658544,0.028562624,-0.05808379,0.033634864,-0.047071714,0.010741158,0.0112556005,0.011313822,0.072576664,-0.04284942,-0.10076798,0.0009036309,-0.0168106,-0.031834338,-0.016201744,-0.04056048,0.006571497,0.06285439,0.18530093,0.0021225759 +3.4.11.19,Known from the bacterium Ochrobactrum anthropi. In peptidase family S12 (D-Ala-D-Ala carboxypeptidase family) [2],384,1.0000001,-0.05424263,0.022306133,-0.13063589,0.012648212,0.032736037,0.038769566,-0.02565995,0.011906579,0.04486709,0.01449013,0.03933284,-0.05974036,-0.043662924,-0.0053817956,-0.08615823,-0.007208394,-0.034205254,-0.029385563,0.01774124,-0.0049317824,-0.00090997067,0.080754116,0.03855237,-0.040197358,-0.043163735,-0.013759923,-0.004694809,-0.006093253,0.00551603,-0.09138114,0.0629352,-0.059755027,0.096819915,-0.057313174,0.14135244,-0.028600642,-0.01716053,-0.054163933,0.12740578,0.013936174,0.030458814,0.020030005,0.012625102,-0.02540448,-0.016709834,0.06274445,0.030100785,0.09021438,0.07089099,-0.0500757,-0.04086302,-0.09677054,-0.030935658,0.017094355,0.029898938,0.007025055,0.022062624,-0.08335626,-0.008907749,0.01343068,0.083843574,0.021971961,0.06116176,-0.0021704172,-0.103420146,0.0008917627,0.067883834,-0.0282699,0.0126514025,-0.021903683,0.0070810895,0.0024809171,-0.026596185,0.13342717,-0.040283445,0.042454578,0.0037993626,-0.048293512,-0.015868222,0.0051343804,-0.05343529,0.03572938,0.08268764,0.017449323,0.023737254,-0.0301783,0.023968557,-0.01017311,-0.039510876,-0.0035638034,-0.021640532,-0.08536298,0.05869387,-0.057729535,-0.06662004,-0.016236404,0.045901317,-0.047456883,-0.0039004653,-0.01941689,-0.05012552,0.017532893,0.0083885435,-0.08867508,-0.0641697,0.05106013,-0.06826599,0.0067675966,0.09429136,-0.0077211643,-0.048401617,0.010780286,-0.03338711,-0.03239853,-0.012080162,-0.04174172,0.032356564,-0.018558891,0.008096727,0.011639631,0.0023540102,-0.02359417,0.004808808,0.0048050806,0.008368585,0.021786476,-0.123374194,1.7895842e-33,0.017363366,0.0025145402,0.029628213,0.03019353,0.04698036,-0.028926844,-0.086658455,0.0071339654,-0.035478458,-0.013615726,-0.11880881,-0.122601695,-0.0049338397,0.00156039,-0.05187666,0.10614376,-0.13847573,-0.02414832,-0.025371348,0.030122926,-0.03910555,0.1024596,0.039162453,-0.023330308,0.058242965,0.114920035,0.08183245,-0.052195147,0.08435297,0.039727632,0.022986948,-0.0572199,-0.13607891,-0.004885894,0.037840556,-0.030906836,0.06575132,-0.10395758,-0.020551465,0.051174242,0.023455914,0.009364041,0.0094461525,-0.05181004,0.07777616,-0.009813921,0.01894662,0.0026746944,0.03284489,0.048942752,-0.016666392,-0.046964422,0.07692422,-0.010886375,-0.06598453,0.021708833,-0.025850093,0.028281676,0.0988038,0.08300824,0.059554517,0.02637778,0.036283303,-0.0072530555,0.031041961,0.04417866,-0.07137277,-0.028167706,0.04623288,0.017433757,0.033405036,-0.06284507,0.024813278,0.0075069685,0.052055724,-0.035935618,-0.006486298,0.00022481245,0.057351764,0.003793033,-0.01749034,0.03276777,0.075330496,-0.06761649,-0.015748585,-0.045585327,-0.044833254,0.025743002,-0.12556171,0.068815134,-0.0039772014,0.016737815,-0.045684777,0.04600883,-0.071979016,-3.4110414e-33,0.042341713,-0.08154834,-0.03126292,-0.07720959,-0.042691432,0.049190063,-0.023264972,0.07811103,0.013288925,-0.0033891057,0.07902455,-0.0271557,0.02203618,-0.036487143,0.048932552,-0.035044227,0.037491567,-0.0043856245,-0.037388634,-0.017007569,-0.047301628,-0.033686638,-0.0035747667,-0.05032447,0.049712636,0.023215614,-0.016203064,0.0636611,0.0019219982,-0.031547986,-0.0004194273,0.031960078,-0.0039093257,-0.07379573,-0.07382237,0.042483144,-0.046978816,-0.032908656,-0.039602265,-0.0036352258,0.040849216,0.03781241,-0.004569215,0.05264696,0.013052219,-0.022318091,-0.07132697,0.03152697,0.042404514,-0.019175798,0.0795291,-0.05932231,0.036289375,0.009589009,0.04220771,-0.019656466,-0.0016918895,0.04124699,-0.012894343,0.080832526,0.024420395,0.041401822,0.043014623,0.08595456,0.087275065,0.062304124,-0.103730775,0.020778807,0.04126055,-0.013634877,0.073979735,-0.0075779757,-0.021373382,0.00029556654,-0.017814564,0.04773414,-0.07962276,-0.03632175,0.052549686,-0.024218103,-0.03155546,-0.10127942,0.0044051684,0.047648713,-0.039387286,-0.079283975,-0.012327494,0.06641892,0.046752993,0.06951915,-0.04147654,0.011334116,-0.020709153,0.06629036,0.028974641,-3.419846e-08,0.07522072,0.00076793303,0.042326294,-0.050159313,0.004582764,-0.055080317,-0.025934111,0.01855665,-0.0074363393,-0.029218698,0.019696165,0.06934344,0.037040185,0.035457224,0.055799417,0.054344602,-0.024309067,0.02231926,0.0060751047,0.08064452,-0.010732011,0.009405624,-0.062372435,0.0067293933,-0.025596779,-0.11620894,0.055576917,-0.0075897602,0.012563558,-0.038208492,-0.035525396,0.019673314,-0.055678573,-0.07166507,-0.016667385,0.026174497,-0.06550959,-0.07198474,0.00043513073,-0.038485587,0.04052662,-0.022038998,-0.07512815,-0.07060791,-0.0022168607,0.019007098,0.009718697,0.024014402,-0.078412294,-0.06251224,-0.018447438,0.03918489,-0.049603224,0.025439104,-0.15500233,-0.013628513,0.017835481,-0.086559296,0.022031842,-0.05144007,0.03324301,-0.030408375,0.16384178,0.10598352 +3.4.11.20,"A zinc glycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family), composed of two 150 kDa subunits. From the plasma fraction of hen egg yolk",384,0.99999994,-0.030418316,-0.022469336,-0.08286003,-0.04493834,0.049489792,0.055692267,0.0610836,0.048919693,0.026084444,-0.010982792,0.025785575,-0.0034111538,-0.017731315,0.0093922485,-0.032700922,-0.053116422,0.018887775,-0.03559935,-0.08157089,-0.0616955,0.02724232,0.014664074,-0.013352851,-0.03028922,0.0107624335,-0.030816084,-0.008836121,-0.0511171,0.002945644,-0.0041728835,-0.05473994,-0.10887792,0.055313926,-0.0101418635,0.07710654,-0.030587181,0.016346786,-0.025545506,0.019884555,-0.042879432,0.107702695,0.13612634,-0.037928842,-0.108354144,-0.01820369,0.030383786,0.05679338,0.009534002,0.015490069,0.06028792,0.004984991,-0.091445975,0.01066039,0.029002657,0.03237691,0.09012347,-0.14183785,-0.030746495,0.024849067,0.0019647437,-0.04520954,-0.005799543,0.013441591,-0.02636621,0.01591061,-0.058456365,0.02140542,-0.004432689,-0.010901725,-0.022117887,0.012959056,0.011023332,-0.03630056,0.0026055055,-0.03208934,0.078560345,0.019768827,-0.0990808,0.016057987,-0.02714269,-0.013650817,-0.0052007823,0.07564663,0.08048967,0.034536477,0.0074672233,0.051591285,0.05193737,-0.033586517,-0.0614863,0.06236914,-0.072216175,0.07618101,0.055862,-0.037361104,0.033291522,0.012854592,-0.06658911,-0.020188596,0.025165984,0.022418315,0.041745685,0.090220094,-0.14261104,-0.04841078,0.09166975,-0.01062922,0.08035592,0.020018987,0.07134418,-0.043438565,-0.038546115,0.0073526935,-0.0007138457,0.029065398,-0.058886833,0.017615227,0.006003886,-0.050305314,0.008400085,0.046330977,0.027849771,0.03006847,0.03925298,0.0029120299,0.115592405,-0.08313085,3.03043e-33,-0.007104508,0.03805322,0.075988635,-0.0018997794,0.03565965,0.032922227,0.027316066,0.055354897,0.06557486,-0.04456945,-0.09243365,-0.063303076,-0.015001574,-0.017802006,-0.074849956,-0.0052708457,-0.025263812,-0.0190157,0.041378733,0.0656752,-0.038031515,0.06712534,-0.0070019723,-0.08541796,0.09869876,-0.023759648,-0.023725722,-0.045369107,0.00481919,0.009132237,0.008624584,-0.07895585,-0.11934204,-0.021147974,0.103588365,-0.038050078,0.08882026,-0.092111416,0.0022004563,0.014007777,-0.017221734,-0.08121045,-0.043490555,0.02352866,0.025239374,0.0020709094,-0.06130781,0.05436234,-0.017102614,-0.046279136,0.027136758,-0.009081765,0.025125777,-0.074708976,-0.09522606,0.01597488,-0.016698465,0.020358758,0.07364577,0.09566535,0.029101992,0.0542287,-0.035826672,0.037173435,0.04979136,-0.012748781,-0.13481168,-0.04290681,-0.023730569,0.087862626,-0.02653055,-0.06574967,0.055246957,0.03223603,-0.014524153,-0.13808437,0.008531474,0.032603174,0.035542842,0.021977108,-0.0030045134,0.04886011,0.000116213094,-0.014980972,-0.0643162,-0.06706854,0.018664254,-0.035910215,-0.032932997,0.008911845,0.0364899,0.021247853,0.012353114,0.023108033,-0.11857806,-3.9943658e-33,0.052646305,-0.058383677,0.046915457,-0.03518346,-0.016767947,-0.021673689,0.029328119,0.04000499,0.01839924,-0.051288836,0.075369835,-0.0064875013,0.024180714,-0.02750484,0.0305765,0.03596265,-0.065141596,0.10717603,0.07554301,-0.022502035,-0.06679412,-0.03095677,0.08509725,0.04808387,0.02025242,-0.010177309,0.0015449125,0.051116463,0.029807368,0.03667859,-0.03581658,0.03906694,-0.046666615,-0.10885483,-0.13408224,0.032681268,0.006005736,-0.0807818,0.019474505,-0.06278878,-0.011898046,0.032239906,0.024273722,0.0030126907,0.025204819,0.077780314,-0.004831403,-0.032471344,-0.025386812,-0.03216814,0.013387724,-0.03886683,-0.0047367276,0.055014536,0.07035707,0.03231072,0.013733535,0.023435349,0.035301127,0.018229835,0.013612971,-0.0070522255,0.0070226877,0.069900006,0.073676676,0.01321041,-0.011534259,0.01005106,0.05864405,0.0026754928,0.017699955,0.013987286,0.044382364,0.03009133,-0.025383089,0.051464576,-0.066003054,-0.06470169,-0.009765969,-0.0053916443,-0.012912346,0.006872449,-0.059638534,0.04579437,0.014709264,-0.10664255,0.06319994,0.14950506,-0.0036619997,0.049497537,-0.034738377,-0.06053928,0.0009144645,0.12844309,-0.0043837675,-2.8903676e-08,0.076335445,-0.040313043,0.01516613,-0.11198451,-0.05411864,0.0020355294,-0.038151745,-0.062381897,-0.008272839,-0.034908384,0.032170117,-0.007899171,-0.039946083,0.0038955796,-0.059980433,0.10645245,-0.084913485,0.048873253,0.026206847,0.067038305,-0.024532335,0.092803806,-0.06231204,0.045349613,0.026866732,-0.021493921,0.037029106,0.10397917,-0.063589066,-0.012067822,-0.04094799,-0.0039563794,-0.02194633,-0.039862875,-0.0011804732,-0.021063413,-0.027282203,0.011101063,-0.0077061686,-0.040438145,0.0020489874,-0.061218232,0.013516209,-0.07736872,0.014345093,-0.060830165,-0.02922772,-0.004684593,-0.02459,0.01979898,0.005930169,-0.014175837,0.008370243,-0.086570196,-0.050895203,-0.029769568,-0.037054457,-0.08339816,-0.036425017,-0.024383007,-0.033086713,0.04707686,0.12730056,0.027576393 +3.4.11.21,"Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, in peptidase family M18 of aminopeptidase I",384,1.0,0.0235839,-0.11491676,-0.086688034,-0.063890554,0.02379354,0.07265232,0.060520533,0.0848921,0.07709305,0.08813996,0.032252833,0.027252238,0.01533993,0.06165777,-0.05310166,0.018341448,-0.014482402,-0.09076422,-0.0002477684,-0.079698466,0.006176664,-0.0112391,-0.05505239,0.0062875003,-0.031624485,-0.030143507,0.0685261,-0.051376734,-0.03653015,-0.021196572,0.037389293,-0.07801066,0.031107832,-0.009272559,0.068444125,0.07753276,-0.064846754,-0.010107635,0.02325676,-0.037663836,0.05078519,0.00984356,-0.044903804,-0.025599057,-0.016414927,-0.0054883487,0.07857372,0.014065028,0.07837314,0.03731017,-0.00421925,-0.024319615,0.008908153,-0.07171442,0.012917064,0.050244495,-0.06449186,-0.04919266,0.02701632,0.01641087,-0.041513517,-0.0029160285,0.0014999261,-0.026701236,-0.046598822,-0.005793561,0.048962377,-0.018153144,-0.03096928,0.0641401,-0.01639455,-0.053130362,-0.049240492,0.040397733,-0.008903993,-0.02320321,-0.030730767,-0.11339916,-0.010352161,-0.046124283,-0.016750121,-0.034971517,0.0769067,0.054047115,0.077335574,0.04552665,0.10466035,0.009164956,0.05263105,-0.079798184,0.04010045,0.0013471094,0.05999929,0.0071011456,-0.080566965,-0.024301132,0.009618291,-0.034176663,-0.03276424,0.0069092177,0.05783617,0.04159693,-0.04405072,-0.024733406,-0.068339705,0.08055405,0.012226585,0.07455412,-0.011188253,0.013694094,-0.057590157,0.03904366,0.011937501,0.041811965,0.0063053467,0.013424077,0.04351236,-0.055884127,-0.012518576,0.027277589,-0.018263789,0.040828314,0.07918234,0.085097775,-0.0048753563,0.04085453,-0.023757532,3.3324938e-33,0.0128829675,0.017436802,0.0665459,0.032018196,0.009544078,0.034265365,-0.0062266965,-0.027184801,0.090482324,-0.06139133,-0.11831516,-0.10461276,-0.0039104884,0.039693877,-0.012742272,0.022417875,-0.0586873,0.015243004,0.048382442,0.0274796,-0.08864817,0.042043984,0.023203565,-0.06978627,0.031153675,-0.021426437,0.038929734,0.035318274,0.038004078,-0.0065223672,-0.044687055,-0.0025205943,-0.09734145,-0.03285124,-0.012329124,0.0098824445,0.033295542,-0.040800277,0.062054478,0.072534844,-0.052300457,-0.0111732185,0.08154089,-0.07820808,0.043706458,-0.019143777,-0.04124649,0.046412654,-0.08290141,0.006314668,0.051185865,-0.06283534,0.10088223,-0.005413506,-0.041364346,0.011173806,-0.05370126,-0.031829577,0.09094458,0.07478164,0.01099711,0.011265662,-0.0043463344,0.02100784,-0.025087971,0.021801243,-0.031692263,-0.07251481,-0.01913286,0.08810976,0.012634527,-0.026346708,0.12444573,0.023067487,0.050119996,-0.09740622,-0.07682681,0.02460752,-0.010953504,0.059895385,0.0014249384,-0.0072237374,-0.02625859,-0.006956258,0.028208664,-0.075346865,0.06521812,-0.039141405,-0.05238256,0.04215941,0.03549021,-0.06061415,-0.067371175,0.012482685,-0.042431917,-3.470343e-33,0.09089528,-0.098453395,0.040317688,-0.020980677,-0.09822265,0.020007052,0.068499595,0.027013341,0.030075973,-0.078756884,0.0572655,0.036498856,-0.02137733,-0.04318047,0.007789486,-0.03545674,-0.017661208,0.022555185,0.038627956,-0.046236515,-0.089223474,-0.051748466,0.006090611,-0.008056807,0.056956552,0.0034906452,-0.08642074,0.0869835,0.0457019,-0.018877491,-0.058839135,0.024583561,-0.038129963,-0.044399284,-0.0012279762,0.06833465,-0.015055762,-0.050235696,-0.072069116,-0.047519077,-0.049860734,0.087500274,0.011188971,0.05278032,-0.0059244847,0.060979497,-0.035025638,-0.032030843,-0.05181371,-0.077223256,-0.0014671755,-0.08410684,0.042995937,-0.017233387,0.03713695,-0.018822648,0.010071132,0.0051708748,0.038690064,0.032890722,-0.00346027,0.008265291,-0.051558156,0.037903674,0.04188643,0.023719566,-0.06556097,0.026559353,0.020415379,0.04998151,0.04479597,-0.039480776,0.054257855,0.080507204,-0.001439694,0.036000967,-0.034259778,0.009797743,0.047998227,-0.065952934,0.024666922,-0.015496574,-0.08781567,0.0033144872,-0.09739889,-0.036487885,0.051915664,0.07076427,0.060295004,0.033548366,-0.0086745545,-0.02405297,0.048387785,0.06049185,0.034671932,-3.089068e-08,0.08616258,0.009714106,0.035018746,-0.120980114,-0.053208504,-0.017433703,-0.0045689535,-0.0057806103,0.042234957,-0.07314239,-0.021568384,0.023767926,-0.0010828689,0.09495513,-0.017350724,0.15482548,-0.03382293,-0.003496605,0.027694533,0.02985364,-0.08521659,0.081521034,-0.13263564,0.010364413,0.03169529,-0.014650994,0.055645328,0.054557603,-0.05668442,-0.009161964,0.0027385782,-0.041513454,0.003008353,-0.03182571,0.042238306,0.09578349,-0.041075792,-0.021726359,0.02359119,-0.09604339,-0.04337847,-0.024457544,-0.009873983,-0.0838261,0.054718062,0.004960084,-0.0151745165,-0.009257755,-0.021455169,-0.04774662,-0.06271969,0.018250754,-0.010046445,-0.11606726,-0.07431893,-0.0187109,-0.040534627,-0.11834536,0.061063796,-0.122430295,0.02337461,0.052521598,0.0862521,0.036903635 +3.4.11.22,"A 640-kDa, dodecameric enzyme best known as the major vacuolar aminopeptidase of yeast, Saccharomyces cervisiae, in which species it was first given the name aminopeptidase I (one), amongst others. Activity is stimulated by both Zn2+ and Cl- ions. Type example of peptidase family M18",384,1.0,-0.0207566,-0.076841615,-0.088074416,-0.07804791,0.017607857,0.05529037,0.013023415,0.098913744,0.049047977,0.025181158,0.027005196,-0.002693979,-0.048766498,0.085177585,-0.08273131,0.003463229,-0.023667695,-0.037045576,-0.00021787013,-0.058429323,0.090021126,0.08172226,0.023025729,-0.005156049,-0.0095559275,-0.058588237,-0.008931877,-0.03279894,0.01576664,-0.08180871,0.013385907,-0.05897072,0.06549395,0.017255006,0.0938437,0.011577092,-0.023872705,-0.004371063,0.055319346,-0.015225827,0.038921673,0.044619873,-0.034117088,-0.063304774,0.0013456964,0.00713685,0.04767839,0.02366501,0.07781451,-0.003688268,0.011577719,-0.098812625,-0.004930717,0.016861629,0.038445175,0.026157133,-0.069218636,-0.0484331,0.029766727,-0.009195517,-0.02306058,0.013141914,0.027419206,-0.006156005,-0.00048918463,-0.02257979,0.043407727,0.00022320048,0.012460957,-0.010205257,-0.040429514,-0.052883167,-0.08407042,0.067371055,0.014698997,0.030888416,2.2356821e-06,-0.06406183,-0.053036164,-0.07482088,0.00775171,0.02802831,0.0482279,0.06547804,0.068007946,-0.0155320065,0.080319814,0.029970625,0.10001763,-0.072495155,0.0125187775,-0.03606765,0.06739581,0.017820552,-0.06920479,0.030458938,-0.013642092,-0.016136197,0.0069038393,0.057912327,0.06800526,0.027496694,0.0070470297,-0.04460463,-0.0030637726,0.13502033,0.020822814,0.063421994,0.051171724,0.0337683,-0.04185408,0.02650728,0.0018932029,-0.016098373,0.018574249,0.024540806,0.045063563,0.005356645,0.006496921,-0.02936623,0.03722696,0.014533845,0.018157087,0.021681994,-0.09956456,0.09202255,-0.09331841,2.3317853e-33,0.0060690874,0.019504314,0.038300037,0.005047954,0.015650796,0.01868028,-0.038703494,0.026871348,0.024049185,-0.04152376,-0.10648074,-0.080832735,-0.028033054,0.05335319,-0.08424456,0.0118006095,-0.036088075,0.0029966661,0.001035749,0.033418655,-0.037562553,0.09289657,-0.010366343,-0.0296779,0.09946489,0.0020587882,0.029555183,-0.01658985,0.07008166,-0.012530428,-0.028758746,-0.06553064,-0.13045844,-0.03494142,0.01480527,-0.009603506,0.07880573,-0.084051505,0.01109292,0.0021522474,-0.004217784,0.022640074,-0.012904006,-0.05545558,0.083200045,-0.04175029,-0.046391595,0.04363343,-0.0063484297,0.020485472,-0.033332225,-0.032099243,0.0453387,0.0022996378,-0.053153798,0.04477548,0.025546895,0.047957473,0.09105697,0.05201441,-0.0021920153,0.01636713,-0.025481619,0.021613717,0.016864365,0.0047500553,-0.08418721,-0.052522127,0.03886601,0.09302262,-0.09494937,0.027352167,-0.016786896,-0.0002229588,0.07453756,-0.15983614,-0.09813764,-0.020451276,-0.018193822,0.048002686,0.012835411,-0.027272021,-0.019209292,-0.038739234,-0.10413135,-0.058022983,0.03334872,-0.042326596,-0.08970184,-0.035090446,-0.0153242545,0.005375043,0.043007217,0.030325558,-0.03954963,-3.5008187e-33,0.053792577,-0.048394963,0.07298316,-0.041955438,-0.04994305,0.050801665,-0.00887112,-0.00095849857,-0.09120819,-0.07182924,0.07317393,-0.028077116,0.07937616,-0.07155775,0.039369956,0.02905517,-0.045635246,0.049333174,0.0059201056,-0.015846165,-0.0694025,0.07759133,0.04222375,0.042014934,0.06283415,-0.015363511,-0.015353622,0.13743162,0.042620633,0.010265304,-0.06535778,0.06816126,-0.020939978,-0.028581597,-0.06926712,0.016992247,-0.01688019,-0.031572174,-0.027411565,-0.0072255614,0.0012290905,0.09386066,0.010944763,0.034938835,-0.05901931,0.076133996,-0.057692043,0.015201452,0.030815626,-0.060127243,0.03074908,-0.04006085,-0.035235766,0.014773692,0.0985579,0.0037765857,0.0038134314,0.057768583,-0.0064041666,0.034820464,-0.0075214137,-0.015268997,0.0147557845,0.011451857,0.058397684,0.029378196,-0.12583241,0.004004965,0.026868071,0.032757245,0.0430469,0.0032085318,0.019799624,0.026757626,-0.05720275,-0.0163449,-0.050733533,-0.067659356,0.00802687,-0.06475206,0.010293707,-0.027124442,0.034161076,-0.011090499,-0.029571734,-0.070374124,0.030797167,0.059624616,0.012908428,0.055471223,-0.00643122,-0.038978986,0.019521978,0.047883946,-0.026053943,-3.6414058e-08,0.118292324,0.01817452,0.043536074,-0.051733527,-0.018617483,-0.07796157,-0.029179806,-0.041097216,-0.027250238,-0.043941535,0.008311814,0.03449896,0.02513531,0.09363428,0.0714627,0.0905911,-0.0534916,0.055123724,-0.0011088887,0.053396836,-0.03135469,0.06607615,-0.119475186,0.034438543,0.017545605,-0.040905807,0.017831769,0.08745863,0.017395843,-0.036917552,-0.028344547,0.020594409,-0.042946175,-0.06814603,-0.035332683,0.096921586,-0.0871875,-0.051676154,-0.022232357,-0.067549706,0.03794726,-0.100314625,-0.0096689295,-0.0439003,-0.029585022,-0.009677405,0.06534758,-0.026609698,-0.039512385,-0.0010400333,0.0022320815,0.01779941,-0.008316847,-0.056114502,-0.12386234,0.02857953,-0.05471143,-0.105824664,-0.0065657306,-0.14808576,0.07063023,-0.029684432,0.12887728,5.7032357e-05 +3.4.11.23,A 270-kDa protein composed of six 46.3-kDa subunits. The pH optimum is in the alkaline range and activity is stimulated by KCl. In peptidase family M17.,384,0.99999994,0.011794459,-0.09600014,-0.074823715,-0.06951871,-0.056369964,0.09874036,0.007951169,0.008485424,0.02753941,0.0626866,0.03727933,-0.047376305,-0.013756924,0.042429745,0.0011943353,-0.010565953,-0.04328135,-0.029429892,-0.057633452,-0.08432425,0.043573022,0.051475536,0.009427611,0.009117023,-0.0636559,-0.002811053,0.051707316,-0.03996302,0.056193437,-0.0847234,0.015390562,-0.017752355,0.08902284,-0.02528869,0.06600883,-0.02675359,-0.067912154,-0.068021424,0.026100622,0.04588525,0.07151418,0.06979302,-0.0286956,-0.027038107,0.01240823,0.011633417,0.010255605,0.00484882,0.07179906,-0.03835909,0.041879557,-0.05172613,-0.06172754,0.06178677,-0.031360332,0.0064811064,-0.1030365,0.020157425,0.11931453,0.026314888,0.01864716,0.057320166,0.051259123,0.015038545,0.030212672,-0.083456986,-0.017009472,-0.051995914,0.011637062,0.016289731,0.009460051,-0.05999597,0.042801227,0.03704591,0.030270426,-0.006176534,0.018756391,-0.10350903,-0.06280262,-0.02135769,-0.010115403,-0.0051365774,0.01982376,0.050076663,0.05583685,-0.075293005,0.03924749,0.012209416,0.041289188,-0.07379239,0.053873222,-0.057211787,0.05883197,0.010384315,-0.067052856,0.058818363,0.0076950938,-0.0065063452,-0.02173021,0.01191216,0.021954348,0.064631864,0.030665137,-0.06670021,-0.019967355,0.041763414,-0.04165422,0.09147458,-4.1051757e-05,0.0710242,0.0013096082,-0.0340689,0.0063581844,-0.040773753,0.069620214,0.0009051298,0.008755215,-0.054106474,0.014845679,-0.018649621,0.040465984,-0.07560597,0.008681892,0.07248715,-0.0753591,0.058669243,-0.10045875,1.2584011e-33,0.06332086,-0.051544435,0.052691653,-0.031534344,-0.03480523,-0.07867008,-0.042156387,-0.039947465,0.02309149,-0.08020626,-0.053634476,0.032319855,0.038046017,0.015136408,-0.09462561,0.023455422,-0.07366318,0.014331898,0.017761609,0.0741401,0.0010738125,0.07287695,-0.015614473,-0.0256756,0.07782486,0.0024398076,0.017023616,-0.044693943,-0.0015234818,0.014951278,-0.0513918,-0.08214804,-0.15016265,0.039972212,-0.054574654,-0.057549488,0.033836253,-0.017505776,-0.034779087,0.0022092897,-0.017296815,0.020144476,-0.009043802,-0.0056711384,0.04034627,0.04229176,0.021415407,0.023397122,-0.03853986,0.038691796,-0.029538158,-0.047195796,0.042974867,0.062396944,-0.050381295,-0.010563898,0.019943729,-0.035865534,0.10232662,0.069182865,0.007412289,-0.010380565,-0.027924629,0.0888267,0.025787923,-0.010383191,-0.105723575,-0.025083287,0.02406269,0.036172114,-0.123618454,0.031651553,0.07967567,-0.06286459,0.020686936,-0.14701757,-0.01646846,0.019736627,-0.08320469,0.12170946,0.041668825,-0.031979274,-0.018659646,0.0081671765,-0.03362988,-0.07153546,0.028728614,-0.023433823,-0.08191772,0.00040244916,0.031096837,-0.013909339,0.02502382,0.102810346,-0.03700643,-2.9389932e-33,0.109773405,-0.060415763,0.081700645,-0.0043660384,-0.01740024,0.036318127,0.10016501,0.040032268,-0.022827946,-0.05547467,0.08222119,-0.033035014,0.020521544,-0.01328385,0.016625866,0.053865615,-0.044629324,0.11001569,0.0021396205,0.021976488,-0.09997739,0.008639009,-0.011686779,0.106519096,0.03176751,0.019073227,-0.036130972,0.005572463,-0.0071722358,0.048947003,-0.043248318,0.0018208536,-0.092366025,0.022434892,-0.09622446,-0.012201495,-0.037796516,-0.022620311,-0.013442648,0.0051418007,0.056282815,0.112451665,0.032722127,0.046241146,0.007911665,0.056961585,0.04476915,0.013798417,-0.0012804389,-0.09517276,0.04364312,-0.037464354,0.0020593915,0.025164953,0.017761433,0.00118337,0.01286367,0.1162808,-0.004478719,0.013798351,0.0007082382,-0.094728895,0.050540723,-0.015777517,-0.0118566295,0.010861352,-0.031245641,0.055584148,0.053058088,0.00079796556,-0.014901813,-0.019689657,0.08339352,-0.0013091959,0.025333896,-0.021258669,-0.07967014,-0.052239846,0.0019367978,0.023286857,-0.00025017816,-0.0386414,-0.03405015,-0.0072696516,0.076499924,-0.0042071473,0.03353217,0.04444462,0.020046366,0.007269505,-0.010585062,-0.028765373,-0.0043496927,0.060762115,0.05887167,-3.479278e-08,0.05306297,-0.061243795,-0.025838424,-0.06373031,0.00013741468,0.03813402,-0.0074167955,-0.003370017,0.049351014,-0.041359317,0.11936145,0.031908643,-0.026544264,0.11538503,-0.0033869643,0.046857275,-0.106987104,0.039850432,0.044905294,-0.011063231,-0.03780439,-0.00019144327,-0.050189704,0.023546072,-0.03020779,0.015730418,0.02816099,0.07675136,-0.04595955,-0.063142374,-0.036847528,-0.04739118,-0.08852313,-0.0028723988,0.037782613,0.052047167,0.019254386,0.006822941,-0.039562702,0.031320002,-0.0043943147,-0.080525756,-0.08218482,-0.05934155,-0.020200985,0.030968294,0.005001976,0.06450569,-0.050016675,-0.04166056,0.021337783,-0.027697604,-0.03614101,-0.11101343,-0.09356068,-0.0034760253,-0.09276975,-0.11386467,-0.040635623,-0.08054453,0.044928364,0.03364807,0.0623598,0.008486416 +3.4.13.3,"A mammalian cytosolic enzyme that also acts on anserine and homocarnosine (but not on homoanserine), and to a lesser extent on some other aminoacyl-L-histidine dipeptides. Activated by thiols; inhibited by metal-chelating agents. This enzyme in peptidase family M25 may be identical with EC 3.4.13.18, cytosol nonspecific dipeptidase.",384,0.99999994,-0.045707382,-0.02221759,-0.088239744,-0.0025473752,0.04992046,0.036050458,0.0017379096,0.0694561,0.012118554,0.031329513,0.05592087,0.00066935393,-0.019142343,0.040696654,-0.065713175,0.013159843,-0.05966685,-0.056388665,0.007307277,-0.086626746,-0.012533298,-0.005801695,-0.04817736,0.009226344,-0.07270982,-0.018319853,0.046676997,0.002501851,-0.037868857,-0.03830531,-0.04993088,-0.05642821,0.07903707,-0.025850378,0.053628396,0.013112596,-0.0729516,-0.0004341057,0.020935295,0.007495435,0.079739936,-0.02732877,-0.069902755,-0.035857935,0.034584515,-0.068514295,0.009846241,0.03319897,0.010408974,0.080751926,-0.03923497,-0.055689294,0.03515931,-0.015901357,-0.08281535,0.009712428,-0.10660277,-0.020274282,0.028050385,-0.03927981,-0.012519332,0.0010948974,0.0014973714,0.0063210535,0.032171916,0.00017587766,0.02400853,-0.052674867,-0.012246827,-0.03154717,-0.020006204,-0.08214347,0.010022832,0.076074146,0.038025256,0.011758532,-0.00054123485,-0.03533596,0.002788548,-0.038615424,-0.0023230591,-0.031177336,0.015442482,0.061663028,0.002433037,0.0065114973,0.0135024935,-0.0059846905,0.032569584,-0.06340915,0.043470215,-0.061703127,-0.028281197,-0.040051598,-0.13741829,-0.017748417,0.0029833675,-0.017932864,-0.017671814,-0.009174071,0.09041268,0.06397563,-0.13994148,-0.02345508,-0.012475958,0.09864176,-0.027681073,-0.008035172,0.06647057,-0.04056296,-0.0483352,0.0014304535,-0.036730025,-0.052326363,0.0004679792,0.048987683,0.052444097,-0.037798107,0.014749673,-0.05064731,0.06175383,0.02165521,0.042076185,0.052273825,0.015483217,0.022152118,-0.082144596,2.5841261e-33,0.042415548,-0.01342655,0.047771182,0.064296424,0.020347819,-0.013591211,-0.0076165595,0.027261022,0.038979623,-0.05046762,-0.109252274,-0.07807258,0.04739122,-0.048229665,-0.023828967,-0.025961336,-0.023920933,-0.046716843,0.0940993,0.034669816,-0.04713504,0.060216825,-0.01269781,-0.026388284,0.0673797,0.04704663,-0.041921616,0.0206258,0.098996475,0.007032228,-0.048840113,-0.025908865,-0.053252928,-0.003185786,0.05013542,-0.008437953,0.04242614,-0.07151851,-5.9707556e-05,0.012765908,-0.0367613,0.0042364644,0.034022555,-0.08206432,0.061620038,-0.071695216,-0.07742317,0.010837921,0.02290377,-0.009079252,0.0571387,-0.041920938,0.14163603,-0.01488127,-0.03669726,0.04586663,-0.027202403,0.029664531,0.079800986,0.10930231,0.030523362,0.021432366,-0.092397936,0.016921233,0.0018799681,0.09588493,-0.06315211,-0.029903708,-0.0076601985,0.122475326,-0.08359215,0.08050077,0.02921031,0.020601427,0.0089051705,-0.050025787,-0.058006905,0.0915698,0.009605317,0.02968329,0.05517627,-0.051988665,-0.019622754,0.027888946,-0.010908849,-0.01649577,0.06566481,-0.014728698,0.00037673773,0.012766544,0.065922886,-0.011060591,-0.031968113,-0.015023511,0.07282451,-4.659752e-33,0.0781477,-0.12979844,0.011089457,-0.03564218,-0.055894803,0.03594922,0.00793139,-0.0061428463,0.003791092,-0.045578416,0.04772519,-0.02902455,0.03494665,-0.07558612,0.004805105,0.05061865,-0.0331382,0.08059969,-0.020009402,0.007870509,-0.11350278,0.02360979,0.058010627,0.04042627,0.05866818,0.0035121501,-0.06127692,0.071394116,0.071144626,-0.005068956,-0.04318139,0.03704196,-0.022031825,-0.14779195,0.024790613,0.05851077,-0.04144191,0.02944863,0.038494624,0.0029920451,-0.02603088,0.00913161,0.058873944,0.11625934,0.019889237,0.13346021,-0.105568975,0.059224125,-0.032882463,-0.06068712,-0.021999802,-0.048140198,0.030436711,0.009546636,0.1111843,-0.039274886,0.035307,-0.042667165,0.046337474,0.021478599,-0.008718123,-0.0714717,-0.070738785,0.016199684,0.041800298,0.03247684,-0.11630368,-0.0010216193,0.075063355,0.0013629411,0.072151415,-0.06795221,0.013019019,-0.02390006,-0.0479498,0.026714176,-0.005669356,-0.042112004,0.043914914,-0.013180454,-0.01673491,-0.015633678,0.0020701464,-0.010873958,-0.058889944,-0.07857519,0.0009932098,0.09618727,0.022836445,0.0095006125,-0.02448324,-0.028971436,-0.010303649,0.011804022,0.015409815,-4.2326914e-08,0.033718556,-0.04994186,-0.010042109,-0.0845954,-0.03837347,0.034925878,0.015237083,-0.07422748,0.061925832,-0.031072365,0.03677955,0.04643605,0.011482582,0.0042622653,0.02936221,0.052300103,-0.030292058,0.078781344,0.029418053,0.085177384,-0.07118505,0.032313805,-0.10210153,-0.0033326368,0.042113654,-0.03348888,0.06797505,0.0017016877,-0.02531809,-0.04199956,-0.02634544,-0.02118578,0.026434897,-0.0011496458,-0.004583148,0.06338123,-0.029602626,0.03451871,0.007484467,-0.045423258,0.0024368968,0.012529457,-0.13429934,-0.03108872,-0.026204577,-0.024643535,0.045256164,0.053245068,-0.009169334,-0.047864124,-0.12704043,-0.029118117,0.039179634,-0.042834558,-0.053529304,-0.037614223,0.0018559743,-0.0858822,0.024533233,-0.09935321,0.059104685,0.036960732,0.17713448,0.0717916 +3.4.13.4,Widely distributed in mammals,384,0.99999994,0.005187217,-0.037755962,-0.022327194,0.027180744,0.0026256817,-0.0002774575,-0.029447924,0.031749975,0.021077536,0.11578303,0.07082945,-0.020995082,-0.042610776,0.11544482,0.012844543,-0.006063377,-0.0443271,0.0068800063,-0.012941016,-0.0012423208,-0.051563013,0.04474295,0.0036075134,-0.0017198599,-0.08455987,-0.08540737,-0.02175509,-0.08061416,0.0015614997,-0.096560754,-0.010339626,0.025529547,0.0986772,-0.08163056,-0.016041461,-0.060518,-0.028635988,-0.027097179,0.07823242,0.062027555,0.063471146,-0.038408708,0.015996316,-0.045740206,-0.05770057,0.0025942125,-0.09890332,0.027886545,-0.0025830301,0.0764532,-0.0017416094,-0.0054733036,-0.046050124,0.1487771,0.028399004,-0.072037004,-0.083939545,-0.06133671,0.029609276,-0.02636333,0.03729835,-0.012132474,-0.024671013,-0.007844695,0.07203707,0.045080587,-0.024609204,-0.0019046678,0.020765381,-0.041923054,0.08809226,0.0225941,0.033376813,0.11022347,-0.03239669,0.02465902,0.027327297,-0.021662379,0.0681171,0.010992709,0.057674907,-0.013078129,0.04607209,-0.009303431,0.09024913,-0.008738839,-0.04100074,0.02245629,-0.12531012,0.006601583,-0.025971564,0.013920381,-0.014429983,-0.08832823,-0.085545555,0.022725416,0.041714653,-0.046543628,0.076688595,0.050589614,-0.01932143,-0.07070125,0.0294597,-0.095506325,-0.0010141167,0.014104894,-0.089628905,0.007259938,0.07011313,0.055051655,-0.06762746,0.06414333,-0.034809817,0.08058501,0.058311433,-0.056948435,0.031043312,-0.04155477,0.0305496,-0.028069356,0.001369264,0.03350818,0.06555271,-0.02229252,0.06250273,0.026438313,-0.00260058,-4.5673447e-33,0.026692674,-0.12450359,0.038715206,0.043382898,0.012277693,0.058682177,-0.03613832,0.00066095445,-0.06060796,-0.036271274,-0.1255704,0.07336178,0.03869515,0.079477005,-0.011541834,-0.0138596995,0.03716781,0.017263072,0.09370385,-0.09670662,0.0030581965,0.04523065,0.044993546,0.0029563922,0.014374087,-0.007203385,-0.06138087,-0.062484197,0.013573768,0.02063624,-0.0044107935,-0.035764206,-0.024605954,0.0012930328,-0.033637576,0.010905022,-0.024055863,-0.08247659,0.023864133,0.04480954,0.104720145,-0.048129354,0.04859584,-0.053455483,-0.0017610153,0.05827876,-0.06308923,0.029968617,-0.025735486,-0.09677841,-0.012307825,0.0024908169,-0.02145742,-0.026016196,-0.033729695,0.022449749,0.004951648,-0.023104083,-0.05561979,0.10365366,0.05422311,0.016650414,-0.074780606,0.0560139,0.10610506,0.009989395,-0.10102389,-0.06635119,-0.04425589,0.04986778,0.062092416,-0.048493825,0.0024916464,-0.1146288,-0.027596315,-0.012723002,0.106753215,0.14565343,-0.04664816,0.086590484,-0.038530096,0.029299116,-0.052933887,0.08545708,0.025044419,0.06711532,0.058799174,-0.030935798,0.051374115,0.01754411,0.06521679,-0.061949506,-0.009843035,-0.09447132,0.040073134,1.25886105e-33,-0.073541395,0.014455742,0.03624369,0.049334712,-0.027997222,0.09273219,0.002794538,0.025942236,-0.026404712,0.039583538,0.0037267928,0.0378084,0.04712764,-0.08393182,0.039745722,0.0011800431,0.09225213,0.05934485,0.06315685,-0.12303559,-0.09385394,-0.058576353,0.011643067,0.015355617,0.14002924,-0.015245454,-0.11062355,-0.0048081363,0.009209658,-0.037582684,-0.08445339,0.016026344,-0.04400622,-0.041795056,0.059852295,-0.012606229,-0.039807834,-0.001830988,-0.0014462045,0.022205723,-0.017520456,0.010874249,-0.05432933,0.050687794,0.06813347,0.029969947,-0.043503623,-0.02851703,-0.044402268,0.07275276,-0.008768343,-0.022117095,-0.033494465,-0.08571448,-0.02934454,0.027926313,-0.04099554,0.018544449,0.052793622,0.0017811358,-0.03888331,0.0029061127,-0.045846514,-0.012095177,-0.017497368,-0.010049242,-0.028730622,-0.015223476,-0.037607204,-0.029636506,0.10778227,0.03390646,-0.0009791041,-0.052339654,-0.018888228,0.06328161,-0.0042776414,-0.052436024,0.060584363,0.07515194,-0.04109339,0.0022166865,0.037995413,-0.023858279,0.02072081,-0.027907254,-0.004673,0.0078074834,0.07537363,0.026357742,-0.03862884,-0.013939359,-0.0817999,-0.05118855,-0.0036214497,-1.5091238e-08,-0.0021669706,0.028129246,-0.02807216,0.0055808853,0.022537684,0.08046941,0.002321279,0.03047339,0.03591958,0.050553557,-0.015064378,-0.010739085,0.085252345,0.028569177,0.038227793,0.037181612,-0.026800318,0.021719338,-0.05525872,0.037340596,-0.063174374,0.012799367,0.010408169,0.0034729915,-0.03692293,-0.069220856,-0.0038261788,-0.00704832,-0.032324336,-0.022213245,0.0060668397,-0.044755854,0.0026306617,-0.038586617,0.0743314,0.02208422,0.028837439,-0.016232198,0.012206109,-0.031864185,-0.012633634,-0.029138463,-0.01843707,0.03341169,-0.028480005,-0.019929346,-0.062933445,0.016537,-0.018900484,-0.08273938,-0.11681117,0.0042278497,0.019606492,-0.0063402853,-0.048914056,-0.0037904228,-0.006794737,-0.12587254,0.03563138,-0.013820102,0.014525378,0.016611733,0.09292893,0.04589146 +3.4.13.7,It is unclear whether the specificity of this enzyme extends to other alpha-glutamyl dipeptides,384,1.0,-0.024039363,-0.11077736,-0.09887828,-0.035298042,0.0767138,-0.019097585,-0.04943874,0.052601893,-0.019934455,-0.078088574,0.06938458,0.021795666,-0.070198655,0.08452476,0.0068443804,0.03471893,-0.057401065,-0.09725093,-0.004634211,-0.007697413,-0.011815819,-0.0028855468,-0.064906366,-0.010526525,0.01919645,0.019069832,0.06841978,-0.02957153,0.019351153,-0.06943725,-0.009640248,-0.038510837,0.024055088,0.023634166,0.10544828,0.036209498,-0.15705733,0.004727738,0.049653206,-0.019761197,0.063323274,0.008396583,0.010630266,-0.024822716,-0.054309353,-0.004835,-0.0002997305,0.01945074,0.031205857,0.091678806,0.024549687,-0.10375195,0.0069612074,0.048394322,0.015063662,0.014375828,-0.122820534,-0.014118377,-0.030530727,0.07831689,-0.059081443,0.028993346,-0.016650068,-0.036497895,0.024702229,-2.2872871e-05,0.009691542,-0.064916186,0.0038666476,-0.07640645,-0.055799168,-0.06303641,-0.01298795,0.031526938,0.001193406,-0.022820972,-0.018745808,0.054664988,0.0799874,-0.057865374,0.07842993,-0.042366393,0.048191104,0.10581401,0.021840205,-0.00751682,-0.031462055,-0.013938259,0.054222908,-0.023014355,0.07022329,-0.06906799,-0.016127463,-0.016087528,-0.020476988,0.031882137,-0.06355584,-0.028498517,-0.052873034,-0.015977185,0.0052707256,0.026786355,-0.06940422,-0.03282459,-0.059176166,0.044738073,0.01601563,0.008040766,0.0074909274,-0.025555274,0.016481128,0.05011216,0.06703785,-0.05978855,-0.03536082,0.018330535,0.041225687,-0.011283355,-0.067531355,-0.029636746,0.04251381,0.03521717,0.10453926,0.067074984,-0.043327328,0.062617876,-0.07344745,-1.4030035e-33,0.089347035,0.0143838,0.014800216,-0.042572774,-0.03627177,0.020904243,-0.06694008,0.023517404,-0.056141526,-0.031528525,-0.11044639,-0.0702737,0.04393402,-0.013895162,0.0128750065,0.046925485,-0.0023331605,0.028352644,0.053619117,0.012957229,0.025162997,0.05724825,-0.004636944,0.04172803,0.021513868,0.052140523,-0.007924637,0.058501877,0.037416972,-0.024257561,-0.033539575,-0.0054189595,-0.13719352,0.07668788,0.042392444,0.061181013,-0.037592623,-0.07092928,0.010392437,0.051209982,0.00924646,0.0106566055,0.059144337,-0.09734039,0.09765288,-0.08168258,0.0025101604,0.0006634158,-0.02313027,0.06007936,0.0047403146,-0.0014336552,0.07503988,0.026896635,-0.017701847,-0.0012905288,-3.9037874e-05,0.05907525,0.053921435,0.041536704,-0.016520739,0.052197225,-0.0676866,-0.019920524,-0.0051777763,0.12737982,-0.047375225,-0.03412062,0.011228715,0.12840831,0.01665379,-0.018690009,-0.00719983,0.076253474,-0.014874808,-0.08621964,-0.046487927,0.07856753,0.077301405,-0.023955155,-0.0067804363,-0.0112247085,0.069902696,0.038987875,-0.12994467,-0.06697855,0.017217416,-0.06285351,-0.034108423,0.01586004,-0.032967146,0.020801518,-0.04823311,0.053838383,0.004952589,-3.5942457e-34,0.08171786,-0.15329847,-0.014328209,-0.094218686,-0.03548112,0.020676024,0.036704063,0.017076911,0.033947524,0.04279645,0.05998402,0.03405641,-0.032254335,-0.038719375,-0.009472475,0.024553584,-0.069103755,0.10706181,-0.0114074685,-0.042341046,0.006953888,0.09445443,0.09071046,0.020563329,0.10941592,-0.014616728,0.06454985,0.053619847,0.059392527,-0.0013253044,-0.07031493,0.03503095,-0.0070545427,-0.044089988,0.051101133,0.039710127,-0.01929265,-0.0007930487,0.0038737974,-0.0028739874,-0.026465496,0.047786128,0.042488653,0.04022225,0.05385253,0.062628016,-0.07078087,0.029655125,-0.039528217,-0.07387758,-0.0029134697,-0.040120233,0.067307234,0.021091815,0.012710941,-0.022246178,0.04832634,-0.02035595,-0.00022502257,-0.047371536,0.0011433418,-0.06796343,-0.034216788,-0.03914907,0.03301272,0.0073953494,0.019814495,-0.0022415903,-0.018548818,0.017879723,0.024101024,-0.122792475,0.041461628,0.05773053,0.0029943225,0.0047043175,-0.01305081,-0.049135555,0.09333592,-0.080309846,-0.010418171,-0.019242272,0.029014597,-0.011222945,0.029746357,-0.05769257,-0.02687686,0.12457703,0.083802104,0.06554052,-0.045266073,0.016170869,-0.023890156,0.00035347044,0.07707075,-2.3775815e-08,0.09051461,-0.029586168,-0.035187807,-0.025350055,-0.0032260881,0.035418957,-0.022752222,-0.05075557,-0.02033076,0.0049604047,-0.0044987453,0.105746455,0.011812752,0.02897034,-0.03491795,-0.0075874054,-0.042679373,-0.025097776,-0.038644865,0.068578616,-0.05787475,0.019232119,-0.06551411,-0.045456246,-0.01237726,-0.08616907,-0.03119771,0.050158657,-0.050580088,-0.02972647,0.027292036,0.033900507,0.035414968,-0.093909435,-0.06281557,0.0668721,-0.015744679,-0.01171958,0.014552411,0.0703362,-0.034186292,-0.073841654,-0.04462575,-0.015652297,0.012917164,-0.032385003,0.015250226,-0.011742931,-0.0063640764,0.032277495,-0.0058822883,-0.029377019,-0.010879594,-0.038145524,-0.06952227,-0.056794688,-0.05775676,-0.031453185,0.037692312,-0.13110882,0.013469939,-0.025572388,0.11884808,0.03894966 +3.4.13.9,"A Mn2+-activated enzyme, in peptidase family M24 (methionyl aminopeptidase family); cytosolic from most animal tissues.",384,0.99999994,-0.018446688,-0.0677415,-0.042234786,0.026217619,0.10212684,0.033126704,0.019953744,0.07012539,-1.7816466e-05,0.08808362,0.063398875,0.00024349421,0.06828822,0.04419206,-0.012831538,0.09104256,-0.066563375,-0.047548655,-0.01646856,-0.028446497,0.09041232,0.03881542,-0.049389157,-0.07519923,0.017949631,-0.00855434,0.06316426,-0.07897719,-0.0033935453,0.0050600003,-0.012429289,-0.05680269,0.09570896,-0.048030294,0.07252172,0.040704254,0.05182779,-0.019269085,0.0107720755,-0.04224794,0.05725309,0.05224271,0.061934464,-0.09508718,0.025285771,-0.015364255,0.047999095,-0.037264057,0.07294925,0.02286298,-0.062032744,-0.08181599,-0.018834,0.015190918,0.017499546,0.043535706,-0.102153264,-0.014088012,-0.0077598854,-0.002668228,-0.0068874913,-0.04031513,0.025748767,-0.014749588,0.022476865,-0.018440688,0.016020596,-0.010242594,0.026494272,-0.010247356,0.03238495,0.0065857135,-0.040229324,-0.014542745,-0.026314745,0.0020963233,0.031771846,-0.035915792,-0.0067141927,-0.016619,-0.04379497,-0.011612909,0.13383149,-0.0019204505,0.047106296,0.07627835,0.048430827,0.018887613,-0.0051457486,-0.042226307,-0.036151413,-0.05440204,0.019809304,0.0448442,-0.09293766,-0.0010737516,0.033038985,-0.0010971297,0.021475604,0.06978833,0.0063166,0.047759876,-0.10398326,-0.09702859,0.03217981,0.031810205,0.0017634592,0.088900305,0.033254486,0.048089195,0.048964188,0.06026019,-0.0044798735,0.047502786,0.03197121,0.02920087,0.05589107,-0.06748027,-0.0039041552,0.0013545871,0.07307557,0.04354009,0.030576197,0.0064582513,-0.03429305,0.074970044,-0.040486354,2.6961078e-33,0.019871898,0.017143391,0.047944345,0.051477514,0.012290496,0.035583567,-0.04130994,-0.04257323,0.069757044,-0.06788214,-0.13128969,-0.083883874,0.002863677,0.028800175,-0.03541906,-0.058706027,-0.01773097,-0.05704255,0.1465779,0.024749134,-0.070750855,0.07893019,-0.027344828,-0.035632756,0.018414889,0.016649941,0.073901154,-0.03059172,0.09976304,0.009298313,-0.043974742,-0.07698012,-0.094859846,-0.037185386,0.005531719,-0.007910674,-0.0039529023,-0.09331579,-0.0029291448,-0.010234951,0.015675072,-0.042042136,-0.0568474,-0.026875218,0.043229226,-0.052361794,-0.10530701,0.028212491,-0.016925085,0.0018352894,-0.020656034,0.0076595107,0.11256035,-0.024118323,-0.12102178,-0.002680995,0.008083365,-0.0390248,0.06894139,0.117709585,-0.01542641,-0.012312154,0.0197012,0.08664638,0.049463138,-0.026993511,-0.05135044,-0.10391043,0.009902163,0.117546074,0.0060497313,-0.08278725,0.04696203,0.009097977,-0.01833905,-0.13790658,-0.008607319,0.033087473,-0.01202246,0.06455914,0.0492573,0.027773673,-0.028664215,-0.016331708,-0.029592142,0.0068257865,0.017986733,-0.08116643,-0.028157126,-0.0125249615,0.05370469,0.010006203,-0.044602647,-0.0042408113,-0.05168424,-3.4128256e-33,0.06509981,-0.012588937,0.056678303,-0.021198409,-0.12833478,0.0010226077,0.01483082,-0.030092,0.038281675,-0.026309276,0.07389357,-0.05228759,0.020252185,-0.058342066,0.02491837,-0.016083056,0.011910896,0.034356434,0.0485556,0.015687438,-0.056864142,0.008397547,0.012905745,0.023760432,0.06399405,-0.005393131,-0.06444075,0.108494505,0.0020847307,-0.032518443,-0.049398933,0.0099448,-0.03841621,-0.082352795,-0.04848408,0.014121959,-0.0658366,-0.05526483,0.016423585,-0.006452459,0.02949394,0.06515991,0.020368911,0.118857995,-0.039469503,0.0027280753,-0.08571947,0.022255711,-0.030298531,-0.05977603,-0.052530445,-0.07141148,-0.018609375,-0.05142955,0.07381722,-0.035067197,-0.029620867,0.006896272,0.037039097,0.021937206,0.0029805247,-0.040800054,-0.019064069,0.08838835,0.03857021,0.071689405,-0.03399838,-0.03254231,-0.0033193314,0.043218542,0.026846673,0.02908015,0.04228129,0.036176823,-0.018033624,-0.014776306,-0.096321195,-0.011213269,0.0020393252,-0.0645425,0.012071901,-0.024150148,-0.02157261,-0.05498616,-0.03248379,-0.11249903,0.031276714,0.16898671,0.041819077,0.031978182,-0.02163173,-0.062150974,-0.011712177,0.017162455,0.005489801,-3.0934736e-08,-0.0016450916,-0.07345182,0.017326418,-0.09670377,-0.0837091,-0.012869768,-0.010995147,-0.06077936,0.043198094,-0.044073507,0.02993015,0.020470634,-0.030522125,0.01334759,-0.010311966,0.13526699,0.024386164,0.050748374,0.00093493995,0.06081468,-0.046570033,0.034830455,-0.10197196,0.07656829,0.056042466,-0.0010662535,0.030418249,0.10912408,0.0075136945,-0.038814094,-0.035086278,-0.013927245,0.027614905,-0.058054842,-0.045506362,0.04810186,-0.008512071,-0.0049733375,-0.01221046,-0.029092034,-0.036915936,0.0026640568,-0.015911322,-0.038152605,-0.058028556,-0.052081034,-0.022310406,0.046558607,-0.013393597,-0.040079087,-0.025351835,-0.03979248,0.011489892,-0.099642195,-0.10218628,0.050430205,-0.010521651,-0.05518724,-0.014109041,-0.0471497,0.026789537,0.046220943,0.08432415,0.0029886533 +3.4.13.12,A Mn2+-activated Escherichia coli enzyme with thiol dependence,384,0.99999994,-0.015262684,-0.07594901,-0.043766487,0.0336661,0.038473707,-0.023964606,-0.013990717,0.102285855,-0.0056488407,0.013507334,0.031816732,0.0004127535,0.037335217,0.04607129,0.06832994,0.022281148,-0.009497722,0.014058003,0.020734394,-0.04110794,0.078437634,0.026395649,-0.08878398,-0.076117165,0.02846011,0.08654402,0.09134192,-0.07066645,-0.08177949,-0.028932719,-0.10348352,-0.04513074,0.11303321,-0.09703771,0.07618664,0.075015284,-0.028067492,-0.011342052,0.00337635,-0.09576617,0.013274361,0.0068734754,0.062602766,-0.057307296,-0.045543857,-0.03455729,0.08754077,0.021633923,-0.016782546,0.04631829,-0.011339295,-0.059155848,0.046971653,0.042223334,-0.0055059576,0.029181316,-0.090726495,-0.0030195809,-0.055432096,-0.018714078,0.0014143175,-0.02183294,0.037962604,-0.00940324,0.039264333,-0.044568244,0.018941956,0.013440452,0.023629773,-0.009916998,0.0072230897,0.05720058,0.016532019,0.014495616,0.020292692,-0.0135434205,0.043056276,-0.028992862,0.07524629,0.01898323,0.0043456126,-0.027494485,0.09059373,0.025368711,0.02349465,0.04706453,0.043113362,0.07234,0.02310782,0.02278317,0.05295162,0.04828609,0.03362121,-0.029381199,-0.03939318,-0.010438877,-0.024906697,0.02163854,-0.010898845,-0.005056598,-0.00024792005,0.06906622,-0.08394083,-0.05784935,0.07657248,-0.029861879,0.05663752,0.08248764,-0.00026829637,0.003816809,0.09945429,0.049417514,0.025311958,0.031210085,-0.0029843224,0.07552935,0.070210464,-0.05870468,-0.0721942,-0.041514724,0.04262532,-0.01487878,-0.042357795,0.009518885,-0.09072491,0.006033921,-0.04340601,5.9719636e-34,0.033528846,0.04578868,-0.022923099,-0.06743715,0.05957421,-0.021457382,-0.017545996,0.010225674,0.03437576,0.012119184,-0.092787445,-0.13590044,0.013363135,0.00817232,0.029699517,-0.099915504,0.00028155773,0.025962811,0.16293468,0.010938136,-0.008872826,0.040310983,-0.014306535,0.009030024,-0.047249958,0.040447906,0.09168665,0.009708587,0.06951556,0.001958193,0.024817588,-0.10244769,-0.052562937,-0.02702875,0.10600848,-0.04362006,-0.07991096,0.052114617,-0.057059895,-0.0074911476,-0.026449641,0.07873385,-0.08589382,-0.00050925167,-0.0066116005,-0.121058285,-0.106891796,0.009811363,0.012464787,0.001029497,-0.004902146,-0.007175148,0.047974143,-0.069522135,-0.025997171,-0.011632838,0.035527445,0.073227204,0.020365192,0.035266984,-0.014812309,0.055834733,-0.01022869,0.09653105,-0.014323179,0.017412651,-0.04239173,-0.07969339,-0.0066608125,0.17031932,0.00737431,-0.070620246,0.004092264,-0.082110435,-0.061042666,-0.03705754,-0.05826452,-0.015308051,0.052676287,0.016414858,0.084144324,-0.032701533,-0.025861006,-0.0062914197,-0.05833418,-0.0062797787,-0.04082425,-0.040297072,0.01704349,0.031825505,0.118028216,0.019106798,-0.032305352,0.006822444,0.012110205,-1.8038541e-33,0.04785949,-0.008177495,0.106372744,-0.090279296,-0.12941147,0.027736688,-0.05520613,-0.033745132,0.012640964,0.0028408023,0.077864595,0.011533824,-0.031745277,0.016239814,-0.008228234,-0.011474953,0.032387026,0.003032143,0.014847035,0.003005932,-0.015772933,0.012594362,-0.013449755,0.008454739,-0.007983615,0.036048993,-0.014165906,0.111751735,0.03573405,0.040968984,-0.0048003825,-0.024594808,-0.03329106,-0.08391828,-0.045726147,0.026058305,-0.014411701,-0.01556193,0.104180865,0.008219986,0.012724558,-0.032807384,0.0013326004,0.116035916,-0.056776073,-0.010754413,-0.031788796,0.006559135,-0.006446693,-0.08099295,-0.057043448,-0.044443298,-0.043115787,-0.029304687,-0.0026143556,-0.018848242,0.0027950061,-0.012545001,-0.0033828148,-0.06226689,-0.00719478,-0.07369231,-0.0044457656,-0.014084663,-0.03299985,0.019233422,-0.01991342,-0.0015918654,0.016113328,0.0095857745,0.019028332,0.043068264,0.014398232,-0.008296362,0.0029313657,-0.08889943,-0.05991301,-0.0043830825,0.02509094,-0.031655874,0.006027896,0.036600087,-0.0425162,-0.07179737,0.02317357,-0.055455778,0.031217944,0.1507127,-0.024846276,0.049445316,-0.009680232,-0.04759743,-0.039161447,0.046291184,0.023964608,-2.3050818e-08,-0.07770087,-0.1595379,-0.030105382,-0.060891163,-0.040252082,0.067961454,-0.030781291,-0.023228912,0.07921987,-0.016012104,-0.01442261,0.11842379,-0.033837594,-0.019817855,0.026635714,0.068342954,-0.00978901,0.0006756835,-0.006716181,-0.0037501336,-0.003391236,-0.0034571511,-0.06571076,0.0053650076,0.016022995,0.039649997,-0.016502934,-0.026144503,-0.022355458,-0.016238397,-0.014731329,0.025378004,0.022500737,-0.020255063,-0.048156932,0.01766229,-0.033986203,-0.028525973,-0.03161468,-0.02920251,-0.007463227,0.08433492,-0.0830065,0.059318114,-0.056610044,-0.034732804,0.031101353,0.0895184,-0.059142876,-0.07234257,-0.020656954,-0.08590422,0.0304741,-0.027019784,-0.04723295,0.059708744,0.024969773,-0.062312596,-0.075247675,0.037348177,0.08320371,-0.010551199,0.12572245,-0.08510305 +3.4.13.17,A digestive enzyme of cephalopods,384,1.0,0.008725794,0.017566249,-0.0018333682,-0.04109757,-0.021168,0.0026910594,-0.023464357,0.021473788,0.048679266,0.029273104,-0.015959019,-0.17032483,-0.063182004,0.017459396,-0.021915909,-0.03664468,-0.015588853,0.019882696,0.026665192,-0.02381595,0.04480053,0.038311806,0.00033808587,0.028664436,-0.0061368737,-0.049522746,0.01172708,-0.066658884,-0.05891098,-0.09154129,0.025529165,-0.08982063,0.08340059,-0.015321662,0.06133755,0.07057674,0.033551604,-0.09228464,0.044122428,-0.0034349205,0.04494432,-0.04039725,-0.011642848,-0.053120587,-0.06682847,0.013087989,-0.074251436,0.006023303,0.033426307,-0.01430793,-0.09356451,-0.16321681,-0.03991284,0.047560353,0.004009296,0.03337166,-0.017715538,0.0021465085,-0.016465755,-0.08102577,0.06646372,-0.018800702,0.03592444,0.042394467,0.030645905,-0.06407276,-0.024723172,-0.04875473,0.023250705,-0.006010985,-0.10836407,-0.077745445,0.027766112,0.0033960089,-0.063504055,-0.011946746,0.007349056,-0.053414907,0.02996745,-0.011779752,-0.010191786,0.024842383,-0.013341259,-0.0086485185,0.03532391,0.07575929,0.027655993,0.032631487,-0.045389675,-0.01913077,0.06214351,-0.069162205,-0.027698629,-0.066027045,0.020168137,0.0083954865,0.036100745,0.010548005,0.08226824,-0.03704943,0.012313741,0.008717505,0.033884574,-0.12622215,0.0021681183,0.042752735,0.018721474,0.029124558,0.0564853,-0.011272521,-0.018477596,-0.06686221,0.034878027,0.022413721,-0.0599653,0.0860584,-0.0029710508,-0.048960272,-0.01234836,0.035538144,0.032811645,-0.044901635,0.019991562,0.0069688098,-0.059078068,0.038375247,-0.083017215,-2.3800159e-33,0.063170224,-0.048832834,-0.037036743,-0.05507717,0.017149603,-0.006461085,-0.010672889,0.09306311,-0.04971904,-0.024434926,-0.072862476,-0.037115026,0.0185774,-0.02377529,-0.002730822,-0.012406834,-0.06334229,0.03160793,0.03198273,-0.027969928,0.03350664,-0.0006718216,-0.019973582,0.0029341616,0.0500954,0.012288623,-0.11042178,-0.041531317,-0.010829368,0.02036239,0.011460136,-0.09758481,-0.0692055,0.11343747,0.013144876,0.011551544,0.024733284,-0.024782358,-0.058334626,0.0031721187,0.03304907,-0.0471268,0.0290681,-0.023887625,0.012209782,-0.035874624,-0.0754802,0.011595956,0.123017676,0.004857386,0.09753575,-0.041875497,0.031792272,-0.04305244,-0.04260668,0.058596045,-0.024538958,-0.020361861,-0.051581167,-0.023612613,-0.031008398,0.051308773,-0.08017491,-0.020416621,0.07710425,0.06360373,-0.046150856,0.07659925,0.032152638,0.04708747,-0.11178545,-0.022933232,0.0070401314,-0.026624603,-0.020012869,-0.016248975,-0.016535172,0.00087580876,-0.049110904,0.036066238,0.06113994,-0.037218925,-0.029429633,-0.019981164,-0.010711966,0.06291034,-0.020452859,0.02867284,0.07696835,0.015059726,0.014672625,-0.045433775,-0.03099438,-0.0197873,-0.07863503,3.1995094e-34,0.11171587,-0.040244956,0.020736715,0.057590965,-0.004490003,0.07071531,-0.0030080762,-0.017715655,-0.004162185,-0.00798766,-0.01193487,-0.008897009,0.08438916,-0.07882274,0.06610623,0.07601579,3.4662167e-05,0.03257415,0.03324789,-0.09160935,-0.0306807,0.05762502,0.008131899,-0.031538274,-0.0057786736,0.053788397,0.035662185,0.047924813,0.028283516,0.039012156,-0.023799637,0.02098092,-0.00892846,0.0021100903,-0.025877876,-0.04122209,-0.11744041,0.02908563,0.097332016,0.054542083,0.017730433,0.013917663,0.02499865,0.0601714,0.0521703,-0.012922452,-0.006274042,0.03986518,-0.014776108,0.044959974,0.027352171,0.017419282,-0.0029744667,-0.06275244,-0.00016698978,0.10943803,-0.015918955,0.036413662,0.055994436,-0.0794614,-0.046656102,-0.029332645,0.082657285,0.062138975,0.04586766,0.087349705,-0.0790404,0.08129468,-0.04085217,0.039887294,0.08660499,-0.03403814,0.0089675095,-0.019760845,-0.0188416,-0.01533835,-0.084422745,-0.031526312,0.07112711,0.009131803,0.003517278,0.0950564,0.104347855,-0.10294673,0.05520802,-0.003471408,-0.0849115,0.009754996,0.009399121,0.010995014,-0.040694647,-0.022721967,0.020292409,0.034652665,0.1497731,-1.5430118e-08,0.10874202,0.029015116,-0.032223586,0.0350893,0.051330145,-0.039461944,-0.023516795,-0.030125368,0.018529547,0.016181137,0.010202665,0.0412209,0.009825616,0.041738622,0.038340542,0.056107827,0.0039018171,-0.048126698,-0.037547275,0.017098574,-0.05068444,-0.02836766,-0.025286293,0.07091437,-0.060117982,0.072108135,0.0430827,0.085718706,0.03126316,-0.0063083456,-0.09821632,0.10238545,-0.026889516,-0.0427122,-0.010732311,0.003296916,-0.09182629,-0.060825754,-0.07574049,0.030286817,0.053496826,-0.051173493,0.069333956,-0.0052293087,-0.05551273,0.023959866,0.06325843,0.023556627,-0.0013348748,0.0036111802,-0.028417123,0.00082430156,-0.018586397,0.01478904,-0.08594527,0.010085305,0.009306681,-0.041918974,-0.10401237,-0.017724816,0.059145913,0.07040998,0.21955112,-0.049234997 +3.4.13.18,"A zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine.",384,1.0,-0.05798143,0.026093837,0.007455518,0.0024099562,0.055322107,0.022808738,-0.047800593,0.058206346,-0.075097255,0.04149888,-0.020381726,0.05362152,0.07385507,0.036760215,-0.07680383,0.07903604,0.03709272,0.066656165,-0.0498961,-0.0019729708,0.048114624,0.014358646,0.019896664,-0.031459127,0.035022862,0.004206563,0.0058341315,0.07090756,0.005972041,-0.015167085,-0.10600343,-0.008907975,0.073487766,-0.008914454,-0.02787471,0.04054262,-0.051636465,0.06471065,0.0091742575,-0.017389283,0.041716143,0.07322563,-0.050282672,-0.10183237,-0.07479578,-0.051010825,-0.011399579,-0.022283083,-0.07197121,0.09324919,-0.12117633,-0.04426216,0.023149539,0.028815016,0.032536794,0.037427053,-0.08357396,-0.0027724474,0.035054833,-0.044771593,0.026111726,-0.09385508,-0.012562985,-0.027865134,0.07236911,-0.021158628,-0.06835137,0.0453969,-0.014245179,-0.02472369,0.032216463,-0.044058487,-0.026527112,0.052888226,-0.013495394,-0.019625263,0.05540537,-0.0432151,0.021729494,0.001274036,0.040461786,-0.0264044,0.09890641,0.105343334,0.07854944,0.077038385,-0.02233119,0.08699201,0.035175256,0.030875802,0.039850846,-0.022206895,-0.046995986,0.008745803,-0.017295297,0.06268725,-0.04817687,-0.004202496,0.0014513931,0.010114799,0.12350861,-0.04969296,-0.043793477,-0.100633614,0.010091887,0.019260613,0.050499342,0.019708944,-0.032149214,0.028977126,0.027747221,0.012696161,-0.016799623,0.016517937,-0.053507235,0.024731275,0.09246919,0.0029073437,-0.05569904,-0.06737146,0.03648486,0.04889912,0.06778786,0.005114453,-0.030587923,0.101134725,-0.109747164,1.0879905e-34,-0.008336805,-0.0041021924,-0.024242641,-0.019222805,-0.0036152133,0.028780535,-0.02441598,0.11740807,-0.03616617,-0.0071502402,-0.06046047,-0.031177348,0.044991102,-0.019370487,-0.06122356,-0.11758553,0.01803605,-0.03473347,0.035395566,-0.033188235,0.02768922,0.016149262,-0.07706673,-0.011031496,-0.013409485,-0.017803643,0.023097917,0.009982019,0.040934615,-0.025302786,0.025539177,-0.10061136,-0.022081442,-0.022814097,0.12941705,-0.0018675334,-0.03295563,0.024915712,-0.00048645848,-0.042882245,-0.0074349316,0.011946226,-0.08939567,0.03100298,0.054842837,-0.046341166,-0.1020542,0.07826494,-0.01426247,-0.026918013,0.05858944,-0.017688528,0.05764581,-0.060731925,-0.14721186,0.09228666,-0.017237972,0.013563575,0.054216463,0.086840965,-0.05712538,0.0321736,-0.06692693,0.09691686,0.01996557,-0.031414695,-0.10318424,-0.10180316,-0.081802756,0.041268483,-0.030065771,-0.09204274,0.04524345,-0.007171244,-0.00910286,-0.08309627,-0.019532716,0.043014504,0.050138842,0.014597355,0.0076241717,-0.045998484,-0.04953613,0.00061749015,-0.092494175,-0.072669595,-0.06476588,-0.12499675,0.040101193,-0.0136034405,0.037427332,-0.043669265,-0.05161425,0.036137644,-0.009830068,-2.3072096e-33,0.042592265,-0.015919402,0.1278727,0.0599533,-0.018952783,0.024182528,0.0065144356,-0.067558005,0.060590938,-0.012357747,0.10151974,-0.04297131,0.044933815,-0.05992628,0.01834102,0.05635904,-0.0049876305,0.04492844,0.06302329,-0.010110586,-0.053768933,0.05376754,0.002178595,0.021881806,-0.0043025585,0.027333079,0.013122449,0.059635572,0.069728956,0.098774835,-0.06797033,0.002465289,0.022846049,-0.07362558,-0.052728694,0.061775587,-0.074582845,-0.06738217,0.0073802224,0.023021556,-0.032931875,-0.023574166,-0.004164342,0.15048961,0.06683603,0.054209124,-0.08138684,0.05285733,-0.043947674,-0.0760187,0.013196098,-0.0024188678,-0.011220251,0.011979172,0.068697125,-0.042890895,0.028020311,-0.024440374,0.0012291888,-0.03822768,0.018257508,-0.03916461,0.002984183,0.0428815,0.043015346,0.05924982,-0.026688827,0.03803714,-0.0043933657,0.008994889,0.031372685,0.048561115,0.013638591,-0.018031526,-0.03620453,0.04319775,-0.03797389,-0.039760377,-0.043875184,0.01619157,0.01553164,0.04220594,-0.015587029,-0.05437302,-0.016374573,-0.04750351,0.010438367,0.07575256,-0.050692104,0.02417727,-0.08384936,-0.037900228,-0.049771953,0.06565504,-0.019766752,-3.220957e-08,-0.008493799,-0.09698727,-0.0024805113,-0.07989832,-0.016981093,-0.022305736,0.020095728,-0.02779729,0.07444242,0.023802334,-0.03451724,0.06553993,-0.015010921,-0.012888697,0.04915786,-0.0148747,0.008993976,0.040715966,-0.034622036,0.029019274,-0.0047881133,0.06871681,-0.053056277,-0.01369141,0.037666876,-0.069406256,-0.0041131726,0.009854593,-0.013497644,-0.051027823,-0.022254588,0.02632641,0.04952247,-0.06491099,-0.078997,0.07515418,-0.04353569,-0.0770227,-0.011609145,0.012043952,-0.02125696,0.038015615,-0.020509606,-0.004618911,-0.0773842,-0.113022946,0.04204648,0.014256168,0.0379245,0.019524056,-0.013983288,-0.008010678,-0.008411312,-0.081199326,0.0049959198,0.03985512,-0.007998037,-0.060988072,-0.0108519085,-0.031375244,0.020713827,0.029315593,0.13536637,-0.0094276965 +3.4.13.19,"A membrane-bound, zinc enzyme with broad specificity. Abundant in the kidney cortex. Inhibited by bestatin and cilastatin. Type example of peptidase family M19.",384,1.0,-0.07529148,-0.007218192,-0.05417015,-0.06486066,0.01374218,0.052123778,-0.023807824,0.09884718,-0.020249365,0.014769773,-0.014297771,0.030620404,0.023239195,0.051493824,-0.09821863,-0.040058225,-0.025671251,-0.0152740935,-0.05481246,-0.058459837,0.010729757,0.035462197,0.00086081616,-0.028789237,-0.0073547144,-0.033403948,0.014233815,0.03444667,0.043102436,-0.024551466,-0.10157129,-0.014686394,0.04510314,0.0073587317,0.03161836,0.023485534,-0.049422048,-0.016834287,0.010553134,-0.0479783,0.05739332,0.07113198,-0.042643838,-0.05280666,-0.02964207,-0.027569022,0.030969374,0.009598167,-0.0040296046,0.016692763,-0.13476989,-0.028911889,0.015864678,0.07061024,0.039585385,0.012905588,-0.08543964,-0.0562936,0.02827511,-0.024700765,-0.006747014,-0.052524116,0.039705813,-0.044114426,0.047002133,-0.0042861677,-0.015317578,-0.00084212795,-0.03304646,-0.03296656,0.06034678,-0.014828166,-0.07030724,0.061695278,-0.043054935,0.07781634,0.013345599,-0.11141684,-0.092754096,-0.018527826,0.032719843,0.022905393,0.08906055,0.094540596,0.08733668,0.0464621,0.006316897,0.09300263,0.002824081,0.032690406,0.05690277,-0.044746846,-0.0019820682,0.047024056,-0.108561434,0.010984075,-0.04347478,-0.028733281,-0.038575344,0.0187457,0.12664099,0.018195637,0.038391758,-0.062372886,0.036104575,0.08332181,0.06557488,0.016430343,0.0026367644,0.016264927,-0.03407543,-0.017000314,-0.043427106,0.020523177,-0.0075729378,-0.004752942,0.07444487,0.03592001,0.0075277523,0.009931183,0.026098924,0.06617137,0.0039817984,0.03128433,-0.03075201,0.08947496,-0.13310651,-1.2011185e-33,-0.06132249,-0.03605037,0.020433117,0.023670387,0.0035780366,0.028181482,-0.02657814,0.07189201,-0.000967166,-0.0907933,-0.12508152,-0.008173602,-0.0149412295,1.6837417e-05,-0.08853935,-0.048729207,-0.02111826,-0.048979614,0.058379747,-0.037426833,0.03302594,0.06448063,-0.06732652,-0.059067428,0.09258983,-0.05565517,0.023844548,0.007549966,0.072268836,-0.0252313,-0.03506343,-0.05318164,-0.08393905,-0.03508745,0.08696921,-0.004805649,0.030183513,0.00055464497,-0.041238282,-0.007914031,0.0014595287,0.0074494025,-0.042132813,-0.0059363754,0.07766381,-0.06889433,-0.106433906,0.07547178,-0.015988398,-0.039872028,-0.0029147216,-0.0050060046,0.05374007,-0.018944487,-0.12787057,-0.006452851,-0.008417381,-0.0039307266,0.080701105,0.085135914,0.020498617,0.023724547,-0.0710153,0.103145465,0.023297187,-0.008979765,-0.13569766,-0.05819385,-0.023938011,0.09435601,-0.06915625,-0.06621764,0.07909994,-0.012851494,0.03523644,-0.13471156,-0.03428678,0.022722388,0.008937353,0.024356343,0.0154833,-0.021026162,-0.0037484132,0.04741915,-0.06517312,-0.058817867,0.02787437,-0.0274151,-0.0345751,-0.02303123,0.050596472,-0.015709497,-0.07037537,0.04504121,-0.09258299,-5.4193674e-34,0.053896077,-0.03517017,0.14600576,-0.017470099,-0.015083069,0.039400887,0.02545895,-0.053912252,0.04629679,-0.036012437,0.07824824,-0.044631254,0.06608059,-0.07658449,0.083661586,-0.00041445123,-0.04023794,0.030313423,0.039516944,-0.016687192,-0.08861349,0.02784461,0.033049814,0.075924724,-0.033277985,0.007055841,-0.021235432,0.022922914,0.020164467,0.03749192,-0.10939101,0.04750868,-0.06717048,-0.050217316,-0.0841927,0.020001592,-0.040265128,-0.05642345,-0.015115907,0.017384961,0.0063980995,0.033980813,0.010299767,0.118949324,0.008089028,0.08824878,-0.042471305,0.027372455,-0.062090747,-0.048963293,0.037286077,0.024884192,0.003191402,0.056566942,0.12189701,-0.059874907,0.040007744,0.010328161,0.0135418875,0.013437415,0.039525848,-0.014863334,-0.047414903,-0.017454103,0.08942065,-0.008125903,-0.05373309,0.020472998,0.050241016,0.034079902,0.0698466,0.05329556,0.029557133,-0.03428469,-0.051910065,0.09263739,-0.029504616,-0.052340742,-0.031175926,-0.040657885,-0.0043761227,-0.0064416504,-0.02743784,0.031504847,0.009345298,-0.035337944,0.05283952,0.053730436,-0.0066749738,0.026512012,-0.0014391505,-0.01006862,-0.027092297,0.06995284,-0.026080262,-2.7099226e-08,0.046034988,-0.051928762,-0.014559925,-0.073876314,-0.041298285,-0.04770395,0.033884607,0.0453317,0.054391637,0.038103923,0.027572148,0.034649093,0.019167298,0.021221401,-0.013258035,0.0749816,-0.058950406,0.026448619,0.025740331,0.06679854,-0.036171608,0.034656927,-0.0784305,0.039503742,0.0199741,-0.04688797,-0.022596462,0.034191027,-0.04506884,-0.02466956,-0.009889097,-0.039099175,0.032512113,-0.06333911,-0.0010594665,0.056586917,0.021992287,-0.04723706,-0.027325325,-0.03427211,0.03704126,-0.040577654,-0.029958714,-0.041691747,-0.003327934,-0.06708214,0.03575013,0.06528674,0.039845727,0.027952269,0.006431249,0.05404986,-0.016719528,-0.08016481,-0.036764223,0.033481304,-0.008384556,-0.052976325,-0.026581813,-0.056129325,0.089441195,0.07387979,0.14445144,0.059486993 +3.4.13.20,"Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs in peptidase family M20.",384,1.0,-0.021025099,0.010116939,-0.08358619,-0.034708098,0.05246542,0.05039667,0.06566047,0.1235591,0.040096693,0.12514172,0.07977515,-0.06619674,0.0075792647,0.012962074,0.0010266552,-0.0050532552,-0.014371378,-0.030752318,0.034185626,-0.090321675,0.041040864,0.040467642,-0.0010818017,-0.024078278,-0.11415974,-0.010961922,-0.000108448476,-0.040315285,0.048677526,-0.027322957,-0.025223903,-0.03375926,0.055216696,-0.030069927,0.056848086,-0.031551488,-0.0023761194,-0.0142993685,0.0148992585,-0.0075946576,0.10201544,-0.02335169,0.039986894,-0.04874244,-0.007207999,-0.017170614,-0.023815786,0.076182775,0.016857017,0.08240098,-0.015876867,-0.019508263,-0.030496348,0.08074098,-0.02282617,0.00033197994,-0.106773525,-0.04202476,0.04915004,-0.034573786,-0.05672269,0.057404768,0.040122196,0.066601366,-0.004216305,-0.06020316,0.012884004,-0.019212013,-0.0054834504,0.0045655137,0.060784485,-0.060379412,0.018076016,0.045361016,-0.00041104187,0.04215044,-0.011746827,-0.032395773,-0.05644376,-0.010200168,0.02925099,0.037501406,0.13928099,0.041860383,0.016838254,0.058780234,-0.045525204,0.042877838,-0.10187162,-0.044842586,0.017109098,-0.063199736,0.04020498,0.03240367,-0.117034845,0.03736356,0.012192605,-0.019640222,0.061671074,0.018561741,-0.03740758,-0.01837157,-0.022160286,-0.0804798,-0.04359092,0.06689862,-0.039496895,0.009929481,0.09861185,-0.0020484945,-0.05426366,0.01216414,-0.043206498,-0.00041290853,0.05781345,0.019444274,0.05609354,-0.020855412,0.025864493,-0.036922615,0.051755592,-0.0025143353,-0.013482042,-0.0050763446,0.03209322,0.043017857,0.028565144,-1.1883549e-33,-0.012641733,-0.060734555,0.09883226,0.027393373,-0.0101195,0.043181308,-0.019786598,-0.030029664,0.003969672,-0.060967833,-0.09040441,-0.068840116,-0.01899754,0.08785856,-0.07830898,0.048799947,-0.003351359,-0.07734175,0.12781742,-0.043468583,0.005094221,0.12409362,0.0008807581,-0.04807227,0.07655354,0.0651732,-0.00831177,-0.025869492,0.051358204,-0.00045878268,-0.024583736,0.017163193,-0.094391115,-0.04622874,-0.046414796,0.007987595,0.04093857,-0.084302604,0.003407001,0.08464874,0.03333687,-0.018110171,-0.003717676,-0.05012866,0.034355074,-0.04653568,-0.040780995,-0.026943129,0.0075537544,-0.01347299,-0.0048495745,0.02474432,0.07431388,0.0028175262,-0.05924493,0.018346231,0.027197393,0.010273572,0.009538927,0.03791824,0.052273188,-0.00727376,-0.03654925,-0.0028929638,0.015958074,-0.036632083,-0.06372195,-0.05540934,0.023831328,0.065155864,-0.035654087,-0.0236162,0.05534614,-0.026405003,0.08025895,-0.098070495,-0.017358338,0.05580499,-0.018985827,0.076441616,-0.01036931,0.0220951,-0.033524178,0.056370065,0.056853488,-0.06229666,-0.029566955,-0.0067111533,-0.03547766,-0.0013258313,0.05980718,-0.018906226,-0.14533372,0.059506245,-0.04538939,-2.4641429e-33,-0.010438072,-0.03816819,0.068565555,-0.004023582,-0.03546018,0.020119663,0.039391648,0.023132928,-0.013171963,-0.022343038,0.03839717,-0.046495385,-0.020684436,-0.038706623,0.026426118,0.008366426,-0.041006904,0.09421573,-0.009190653,-0.037127666,-0.056228764,-0.029683629,0.04774316,0.0012483232,0.062322702,0.011571741,0.010219558,0.058438014,0.048713118,-0.038571365,-0.05079069,0.09632754,-0.06455337,-0.08490564,-0.026333876,-0.046208527,-0.0574573,-0.0366461,-0.066914104,-0.05197722,0.022530302,0.124638714,0.02905409,0.07605198,0.047348395,0.10978524,0.02556064,-0.014856833,-0.032991048,0.008740592,0.006392105,-0.042331595,-0.01198186,0.008988563,0.066180095,-0.049782723,-0.060336556,-0.025578476,0.033689246,-0.01261206,0.014451468,0.009847963,-0.09244806,0.0158053,0.055148397,0.026795534,-0.028466128,0.066198565,0.04393204,0.010645762,0.09251054,-0.050766245,-0.0062504946,-0.055514526,-0.0090877535,0.069525585,-0.11623443,-0.06290309,-0.01224366,-0.034855045,-0.04537866,-0.043668497,-0.013406682,0.005842085,-0.009473063,-0.049151875,-0.009782958,0.07607641,0.021323003,0.055452954,-0.050830603,0.013502747,-0.055137876,0.026353324,-0.03238214,-3.050715e-08,-0.0073552276,-0.04131204,-0.00570148,-0.085625894,-0.06504661,0.03323954,-0.042566475,0.027158773,0.020334043,0.011373224,0.026862996,0.0021346149,0.030751245,0.04041708,0.029365228,0.12538894,0.016068283,-0.014854558,0.011689241,0.014373376,-0.08839846,0.03517673,0.0012659975,0.03715108,-0.043204922,-0.005105348,0.016957657,0.05599383,-0.015243122,-0.054327436,-0.07791393,0.046970464,-0.05642034,-0.03773958,0.055773918,0.035454918,0.053613942,-0.05876292,0.02404998,-0.07822037,0.028519666,-0.04414183,-0.07586079,-0.023045788,0.027721277,-0.08101603,-0.01503737,0.0636856,-0.081342466,-0.17006524,-0.10994651,-0.068349056,-0.05541197,-0.056800827,-0.100226976,-0.07057157,-0.045656864,-0.026705047,0.033217933,-0.120259315,0.04453566,-0.004927762,0.11036289,0.06507173 +3.4.13.21,"A free carboxy group is not absolutely required in the substrate since Asp-Phe-NH2 and Asp-Phe-OMe are hydrolysed somewhat more slowly than dipeptides with free C-termini. No peptide larger than a C-blocked dipeptide is known to be a substrate. Asp-NH-Np is hydrolysed and is a convenient substrate for routine assay. The enzyme is most active near pH 7.0, and is not inhibited by di-isopropylfluorophosphate or phenylmethanesulfonyl fluoride. Belongs in peptidase family S51.",384,1.0,-0.01697482,-0.08083776,-0.082678,-0.0025504893,0.11297441,0.07552095,-0.043301556,0.08890453,0.016372569,0.018978229,0.069410816,-0.037333626,-0.0800447,0.07792971,-0.02974729,-0.017641786,-0.007848828,-0.042164743,0.057352636,-0.05674063,0.004249269,-0.018183662,-0.008910727,0.022644991,-0.006706927,-0.047652043,0.0056914524,-0.043556523,0.07382625,-0.0880102,-0.025624938,-0.0033342722,0.085194595,-0.02242792,0.077756345,0.0014148391,-0.04671786,-0.027067393,-0.002080526,-0.028642453,0.04923233,0.0007099411,-0.01948119,-0.04234936,0.042481203,-0.0010179704,0.016091065,0.054228254,0.072745405,-0.029334484,-0.018988317,-0.014440288,-0.024002498,-0.0056402083,-0.105525106,0.019065939,-0.07630677,-0.06662099,-0.07372342,0.03744824,-0.038050856,-0.0033714548,0.042546775,-0.023888972,0.019844161,0.02615521,-0.09640037,-0.017507032,0.070811234,0.0018385599,-0.07104943,-0.08607601,0.06335301,0.03710413,0.031899836,0.036235966,-0.026371341,0.032358017,-0.014225765,-0.0068657645,0.05466725,0.0067072986,0.09946968,0.10444531,0.05144255,0.019466436,0.01683542,0.0019776411,-0.0011329266,-0.051109377,0.037565615,-0.026582116,0.035166852,0.00845193,-0.05936146,-0.051123656,0.054170422,-0.022092579,-0.06453551,0.04498501,0.019615935,0.020215748,-0.05862389,-0.013428476,-0.054812882,0.020467773,-0.003463401,-0.014468732,0.0842084,0.029679593,-0.035606287,0.061916992,0.01891239,-0.098369956,-0.067985386,-0.03174145,-0.035486862,-0.09414276,0.03925523,-0.024689974,0.032367397,-0.036713462,0.051809143,0.112660415,0.014577954,0.08216567,-0.061373416,6.3737846e-33,0.021852378,0.055131722,0.07264722,-0.03185999,-0.070541725,-0.046765197,-0.04924483,-0.015894286,0.03758322,-0.04556439,-0.103005536,-0.089816794,0.030952783,0.0436434,-0.013782631,-0.04810109,-0.055574585,0.025352683,0.05309061,0.005401561,-0.020268943,0.0094126295,-0.0496179,0.037080325,0.04996407,-0.059455846,-0.078381665,0.005903699,0.032548867,0.00020642273,-0.005621205,-0.03473039,-0.14066066,0.031227238,-0.019191125,-0.03124872,-0.061870303,-0.12113463,-0.028593479,0.045116436,-0.040556747,0.036662787,0.05322573,-0.06561113,0.06348852,-0.10156418,-0.04925402,0.027184162,0.02317259,0.04550487,-0.0033148897,0.0096874405,0.012998061,0.03428804,-0.020498328,0.006429744,-0.033523045,0.0074512814,0.06690108,0.08923466,0.018710377,0.010657356,-0.07689394,0.014701458,-0.076890334,0.110830516,-0.07353071,-0.022481915,0.04594103,0.092751056,-0.025932442,0.027443318,0.056863677,0.072891064,-0.0040658456,-0.05645853,0.0051040268,0.07266499,0.038416147,0.04319743,0.06762008,-0.023073329,-0.032673728,0.006107772,-0.034509245,-0.028505474,0.026726693,-0.078970686,0.003547816,0.03574736,0.0059145214,-0.045900937,-0.023150641,0.040279225,0.0030467173,-6.509962e-33,0.054852482,-0.121771246,-0.0060906196,-0.06183162,-0.036069445,0.025156828,0.039730445,-0.011905905,0.06976609,-0.020880459,0.030869406,0.046370365,0.0088683255,0.0015086735,0.04454607,0.035282634,-0.066917375,0.07930342,0.053998943,0.05862417,-0.023714727,0.09795063,0.08798152,0.049130164,0.026250048,-0.0003119172,-0.0033255925,0.055346634,0.067500174,0.048632484,-0.013958301,0.08321358,-0.09181511,-0.052574016,-0.026981577,0.0025215405,-0.09988833,0.03242865,-0.033960886,-0.034086842,-0.024279907,0.05756272,-0.0063859653,0.011824079,0.009757209,0.06506579,-0.08105365,0.023433456,0.10594005,-0.057072666,-0.028198108,-0.031692967,0.044612706,-0.015709858,-0.0077549126,0.02442917,0.02911772,-0.005715636,-0.04272208,0.031071955,0.019733744,-0.06706566,-0.061559517,-0.060913943,0.06482603,0.012063846,-0.031610817,0.035134353,0.06955728,-0.021109348,-0.012589725,0.013261546,0.07233503,0.043348897,-0.017937304,0.032047484,-0.0595592,-0.02830272,0.039675683,-0.051937606,-0.022548491,0.0016442157,-0.069212765,-0.035825536,-0.007484215,-0.03305636,0.010907471,-0.0008532868,0.00842662,0.057959158,0.046995256,-0.052542172,0.0007869708,0.0501243,0.039307814,-4.7602963e-08,0.1777463,-0.050827123,0.059941847,-0.057343867,-0.05227342,0.047922514,-0.0059673614,-0.12868376,-0.025230428,-0.024204912,0.011681779,0.058641452,-0.041629028,0.05562534,-0.0047906186,0.067731984,-0.08605065,0.067856014,-0.044749957,0.044099014,-0.06158255,0.03325635,-0.079899676,0.04879881,-0.008240614,-0.046920307,0.12442272,0.056289982,0.016042747,-0.047114752,-0.04601464,0.010527594,0.0051873345,0.028017279,0.029745843,0.06370966,-0.06554517,0.02707201,-0.022698931,0.06091812,-0.013132001,-0.0205848,0.005442409,-0.046476606,-0.0013287239,0.025566692,-0.004757511,0.04648476,-0.04534914,-0.016404912,-0.008064286,-0.04441047,-0.04189866,-0.014413727,-0.08333207,0.011300234,-0.03677454,-0.08534085,0.045982555,-0.081562504,-0.053096958,-0.01805701,0.16831015,-0.0064078905 +3.4.14.1,"A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family).",384,1.0,-0.05219903,-0.115451865,-0.0768327,-0.06799319,0.06514289,0.037226275,-0.029659975,0.06424785,0.06172595,0.030141406,0.062301748,0.021515047,0.004736533,0.058437638,-0.0009482797,0.0020485327,-0.060358763,0.012686039,0.0029724888,-0.032477252,-0.022326147,0.020300684,-0.04070177,0.07891386,-0.073541,-0.019257603,0.07241493,-0.043172915,-0.0040975204,-0.071646206,-0.018345062,0.0003276538,0.06948779,-0.029917166,0.035096295,0.057872977,-0.032631982,-0.008279375,0.09255422,-0.030022513,0.07725587,0.013887045,0.024078539,-0.12121142,0.003058494,-0.026761752,0.0023893835,0.067608446,0.05984295,-0.025536394,-0.030377131,-0.08714503,0.00026883255,-0.036928467,-0.022490742,0.03008957,-0.079247385,0.016138513,0.06679006,0.021962099,-0.040900063,-0.0027681515,0.011515046,-0.0068421806,-0.09861253,-0.05137067,0.017884769,-0.0074191038,0.009186933,0.026730599,-0.031728666,-0.05979764,-0.025457006,0.025637263,0.028053157,0.047585204,0.032916147,-0.079830416,-0.08831515,-0.026867947,0.008220645,-0.04327454,0.019280888,0.08436105,0.054579172,-0.03295457,0.029945502,0.0528914,0.04476036,-0.08318635,0.0663003,-0.049040545,0.016645461,0.019254996,-0.115745395,-0.017441409,0.00693447,-0.050462436,-0.0069591273,0.026517715,0.050707024,0.057110567,-0.008031869,-0.06844242,-0.008343253,0.037038583,0.010834335,0.06390267,0.04672126,0.0044202423,-0.03003381,-0.0063069225,0.008329342,-0.1191172,-0.08495566,0.0006644168,0.045510102,-0.040788162,-0.0025770394,-0.057584908,0.04791436,0.031704802,0.02424034,0.04540544,0.0063516134,0.016078742,-0.052888114,1.7572294e-33,0.020196363,0.006955247,0.07732961,0.038277745,-0.017667456,-0.0011861759,-0.034108646,-0.02584587,0.008922101,-0.14418949,-0.036349114,-0.0055620293,-0.023685183,0.010507348,-0.040595226,-0.008365983,-0.043030243,-0.013361131,0.013334457,0.037735388,-0.031870965,0.036473803,-0.01230182,0.03539319,0.11407509,0.003566948,0.067050286,0.026447823,0.021468166,-0.013802054,-0.08203529,-0.008566914,-0.11328837,0.0425307,-0.007656116,0.041139226,-0.019878412,-0.06260094,0.03820782,0.03297373,-0.06627507,0.021048471,0.014015745,-0.07768127,0.028883494,-0.04027852,-0.00053515984,0.038565733,-0.052240465,0.0006255275,-0.0015893044,-0.06747674,0.075526446,0.0272501,-0.061471514,-0.03928243,-0.02295205,-0.022861032,0.07917113,0.041842747,0.07736544,-0.030802278,-0.065618165,0.035169024,-0.042939965,0.04785222,-0.08518964,-0.03031476,0.0036495663,0.0906384,0.006983376,0.03567514,0.08128125,0.030385658,0.031761296,-0.08320815,-0.049748007,0.033493202,0.057638336,0.12288522,0.056627985,-0.030025253,-0.021292673,0.017081805,-0.053795766,-0.054146234,0.039790373,0.027955867,-0.07803995,0.009662545,-0.0671018,-0.057369906,0.0869576,0.08355966,-0.046290457,-3.674559e-33,0.09269988,-0.058986958,0.048007447,-0.032965776,-0.05844093,-0.0105484985,0.009816289,-0.015711375,0.009493036,-0.08321921,0.0006398315,-0.042150922,0.004182794,-0.020572819,0.012769514,0.03067335,-0.0139491735,0.054171592,-0.028214362,0.00698457,-0.11437548,-0.008262613,0.06358941,0.07016834,0.059382252,-0.009142522,-0.057080798,0.07929959,-0.0053883367,0.026408598,-0.099077776,0.012377134,-0.06966882,-0.040337525,-0.03388177,0.08835292,-0.030925835,-0.008559175,0.029296868,0.0017226669,-0.004955713,0.012174275,0.029281566,0.060774613,0.028711215,0.048990656,-0.044547904,0.036478054,-0.051600557,-0.072720475,-0.014764104,-0.017320937,0.05254824,0.05028552,0.025923906,-0.0034459417,0.0010935388,0.044979393,0.020471426,-0.017257988,0.0003020665,-0.04760909,-0.117095575,0.03257907,-0.053151544,0.03193677,-0.08604112,-0.03174629,0.059742704,0.011259051,0.06651687,-0.026872138,0.096817754,0.054177895,-0.011150402,0.042688444,-0.06248119,-0.100882106,0.0023891057,-0.03496629,0.013939035,-0.06966881,-0.030663801,0.01679605,-0.02599693,-0.02665489,0.0014679988,0.0030066129,-0.013981537,0.014960402,0.009167229,-0.006675809,0.1327066,0.11601908,0.051423207,-3.507917e-08,0.10120396,-0.06886867,-0.041394077,-0.08839157,-0.08452342,-0.022780048,-0.0010467251,-0.07549368,0.011047803,-0.009026606,-0.010255162,0.051432338,0.0052716956,0.07660213,0.02180098,0.12511882,-0.039131183,0.067654826,-0.00092022296,0.06284856,-0.06028621,0.064075574,-0.10555245,0.028224241,-0.0032820187,-0.008623616,0.08641078,-0.015841713,-0.06671842,0.010294618,0.0403981,0.014054389,-0.022484234,-0.0075991713,0.05624272,0.07811856,-0.017351443,-0.019079825,0.007665172,0.022899898,0.011648626,-0.021586055,-0.13673969,-0.048297785,0.024475655,-0.044608667,0.0017695487,0.046159636,-0.0127317915,0.021644672,0.029085353,-0.0031354446,0.008972338,-0.08702536,-0.051396858,-0.011348026,0.0063610096,-0.037782807,0.073135994,-0.111539245,0.046388198,0.022866925,0.17951219,0.028036123 +3.4.14.2,A lysosomal serine-type peptidase in family S28 (Pro-X carboxypeptidase family); maximally active at acidic pH,384,1.0,0.023537489,-0.110787824,-0.109975114,-0.06584309,0.08895182,0.12137843,-0.008091733,0.07899919,0.008196897,0.017991113,0.04127656,0.023802605,0.012015439,0.035217393,-0.0024764717,-0.019232007,-0.07872603,-0.058807116,0.0037186488,-0.033584483,0.060510986,-0.008734659,0.014901286,0.067724824,-0.042308405,-0.03996267,0.004670918,-0.05510266,-0.032717627,-0.05240571,0.039587073,-0.048748255,0.074914485,-0.03587263,0.10048495,-0.050712503,-0.029890636,-0.01966117,0.08848684,-0.056716967,0.024889378,-0.005884838,-0.04866203,-0.07034125,0.0060671545,0.034929533,0.0494705,0.06743198,0.0243767,-0.02357365,0.022765141,-0.10007154,-0.051946018,-0.04030391,-0.03860455,0.0300081,-0.050518863,0.014457049,0.054503404,0.03913184,0.02607391,0.025054725,0.07872643,-0.042001788,-0.012385602,-0.06002119,0.026610354,-0.0045470614,0.038328134,0.015309185,-0.004253169,-0.03888705,-0.029779267,0.08975821,0.012025944,0.029536253,0.01513784,-0.039575674,-0.055552512,-0.014505449,-0.0064581367,-0.054025024,0.045825306,0.054033928,0.044374466,-0.07570367,0.0199653,0.06316728,0.05187724,-0.023106923,0.045930598,-0.11999649,0.052263014,0.051490832,-0.06549909,-0.051751688,0.028939134,-0.028566074,-0.04426984,0.0006986407,0.020624625,-0.00044639604,0.035775036,-0.0706793,0.008531683,0.09121349,-0.030649055,0.043963257,-2.1976099e-05,-0.021059506,-0.015493941,-0.0009324694,0.032706942,-0.058683515,-0.046107695,0.0075702732,-0.011276073,-0.028087856,-0.02024688,-0.0045281257,0.043280885,0.014752426,0.030676343,0.036423944,0.013185343,0.056115888,-0.10522437,5.4796023e-34,-0.044241574,0.029465005,0.07138537,-0.0029594726,0.010639889,-0.023412583,0.0015032507,0.0116141625,0.02193518,-0.035327174,-0.08945899,-0.0663795,0.006803008,-0.057952907,-0.084368646,0.046261426,-0.08255497,-0.06669002,-0.05907809,0.07102455,-0.041673344,0.007558981,0.0026637139,-0.008363339,0.055130735,0.0018256826,0.07501324,-0.04874465,0.065704495,0.022708671,-0.063355796,-0.06054516,-0.063784204,0.071520254,0.014254319,-0.021784281,0.052250214,-0.102795735,0.014591162,0.033196513,-0.0014132212,0.018446274,0.0026968978,-0.04055298,0.052074138,-0.0479232,0.013494313,0.06649453,-0.057302684,0.05888477,-0.025162304,-0.087507114,0.05832492,0.062484063,-0.061232515,0.020942234,-0.037034128,0.017263185,0.06329926,0.04573982,0.074566744,-0.023572225,-0.017785627,-0.009232915,0.012939025,0.040473554,-0.14649728,0.0029456222,-0.013867054,0.070269845,-0.0015461759,0.01258994,0.11872301,0.0020103115,0.02774387,-0.0766774,-0.051434323,0.07578829,-0.007666855,0.090899475,0.05920836,0.029045414,-0.032350592,0.00037239146,-0.047795646,-0.038872525,0.026104305,-0.005149558,-0.14124466,0.023759868,0.011042897,-0.06689211,0.055597797,0.053511973,-0.08054398,-1.46828125e-33,0.042467415,-0.025939705,0.03270823,0.009439534,0.016804807,0.026199557,0.038077205,0.009147358,0.007940058,-0.012630453,0.0067069526,-0.0020611156,0.023554787,-0.06657541,0.007581897,-0.02415523,-0.022802712,0.06409068,0.004454322,-0.017151004,-0.074766874,0.069335364,0.008859345,0.07415246,0.046329226,-0.036710024,-0.051562183,0.14915064,0.07247897,0.0049768793,0.004671182,0.021464087,-0.010238381,-0.0734227,-0.047615923,0.0115875695,-0.011332571,-0.012398695,0.024533927,0.04318803,-0.04938232,-0.0064842682,0.02633067,0.047975037,0.05004072,0.09361963,-0.045717444,0.0394644,0.086812384,-0.059163857,0.04993324,-0.08695961,-0.027105242,0.025459768,0.017350912,0.00057305,-0.029786257,0.09758278,-0.06725781,0.028301172,0.014414506,-0.020775707,-0.01074326,0.04566541,0.001022558,-0.03961121,-0.12704214,0.0029551662,0.1265956,-0.016430663,-0.01591148,-0.009170518,-0.0035049159,0.019365469,0.022144634,-0.000318527,-0.13015148,-0.08210981,0.062093195,-0.057512954,-0.054018248,-0.06645431,0.042729788,0.006226419,0.06921904,-0.036910426,-0.013864942,0.05776179,0.027009292,0.03724968,-0.00666468,-0.05711431,0.032797545,0.094661444,0.025345095,-2.619179e-08,0.11786896,-0.060904406,-0.017506253,-0.053472016,-0.036536936,-0.03487331,-0.04358457,-0.014697166,0.0074708196,-0.053538427,0.038698398,-0.05290052,-0.029482909,0.069224305,0.0044721994,0.06329036,-0.020212866,0.1309868,-0.041928742,0.05569316,-0.038940094,0.007904489,-0.04713877,0.037023876,0.02463187,-0.030215543,0.05045032,0.03718451,-0.026451815,-0.056661792,-0.014803054,-0.058160707,-0.051357847,-0.00063256756,0.020323945,0.026132267,-0.058094427,0.004356289,0.046647638,0.03371148,0.05872389,-0.07582597,-0.08027898,-0.023681208,0.013214549,-0.02242882,0.018513508,-0.0007343923,-0.0469998,0.0020869547,0.03323469,0.02687282,-0.09275543,-0.04342647,-0.036571436,0.043363065,-0.023103952,-0.05865275,0.07144273,-0.110003814,0.03699026,0.07110665,0.1707892,-0.0033557254 +3.4.14.4,"A cytosolic peptidase that is active at neutral pH. It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2. Active in the hydrolysis of enkephalins. A metallopeptidase, the type example of peptidase family M49.",384,1.0,-0.003221635,-0.13381788,-0.0491212,-0.014263393,0.09600721,0.0697274,0.08130431,0.07970138,0.027558118,0.055661272,0.039739493,-0.012831488,0.0053772423,0.07442689,0.008259382,0.026304012,-0.040242083,-0.03353432,0.010895598,-0.055508576,0.055751722,0.0297057,-0.019660275,0.023116382,-0.066660166,-0.02102179,0.021054015,-0.032169677,-0.006777547,-0.06563335,0.0386234,-0.04399008,0.021245837,0.015935514,0.07740279,0.052620456,-0.039604057,0.00736473,0.007371689,-0.047464043,0.049566533,0.024354683,-0.014241934,-0.09697613,0.02888017,-0.013685752,0.0028429697,0.026380658,-0.020174375,-0.015907891,0.0070834546,-0.07192446,-0.047642957,0.0024592883,-0.03781109,-0.00035945806,-0.066532135,-0.017628586,0.0685138,-0.016282912,0.029776793,0.00858031,0.016755223,-0.015109753,-0.012199126,-0.054557916,0.014970127,-0.027003994,0.0480452,0.023324853,-0.02856352,-0.10681619,-0.062211,0.04032751,-0.02036202,0.0013263164,0.03916913,-0.10448319,-0.06590026,-0.00460047,0.0054370533,0.015486762,0.05885603,0.055104963,0.075928025,0.017715424,0.00024428873,0.031953003,0.010387921,-0.0025737628,0.021775788,-0.09182074,0.04913182,-0.0013263637,-0.07116541,-0.026087549,-0.009675493,-0.025919432,0.001049239,0.072088026,0.033603773,0.071777955,-0.03089691,-0.05718629,0.03396727,0.0832905,0.030786635,0.047923274,0.0660907,-0.0075725075,-0.06609036,-0.031371474,0.030121224,-0.06501221,0.015395435,-0.018400105,0.058609538,-0.042726226,0.0019703258,-0.044014893,0.059996147,-0.031630535,0.020469986,0.018186068,-0.033693485,0.13242126,-0.113809764,2.2803174e-33,0.015729256,-0.03799643,0.13684891,0.05536413,0.002419269,0.019894814,-0.01911621,-0.01733532,0.06327765,-0.036111634,-0.06209212,0.009531164,0.022839671,0.05957369,-0.060152654,-0.03090438,-0.083486274,0.055195406,0.04158594,0.017424433,-0.045256346,0.06589764,-0.029279927,-0.06503513,0.069700584,0.0048340126,0.015835278,-0.022719346,0.071593545,-0.00931223,-0.02581081,0.0008999575,-0.13301817,0.019434746,0.026197037,-0.021664217,0.04594421,-0.05062649,0.06312641,-0.04221621,-0.093760215,0.006091796,-0.009246202,-0.070097744,0.07567455,-0.072319455,-0.051529404,0.085795715,-0.031513464,0.008946376,0.045335464,-0.05090517,0.076388344,-0.006359568,-0.04691987,0.002370395,-0.005256486,0.02195189,0.08448466,0.07941002,0.048782453,0.0020797157,-0.08226438,-0.04396811,0.033713073,0.005058406,-0.07574633,-0.030725628,0.034644514,0.09249638,-0.02604255,0.05376462,0.0999643,-0.010592193,0.050055854,-0.117611706,-0.048571054,0.040542647,-0.009673446,0.090755954,0.047879007,-0.020097675,0.011589093,0.013653868,-0.035679046,-0.05524494,0.008457573,-0.05110504,-0.05224908,0.023072755,-0.030431053,-0.012709661,-0.02548431,0.073259726,-0.06419405,-1.6588108e-33,0.10085937,-0.01781085,-0.05222163,-0.019655207,-0.03257192,0.022374334,0.034610637,0.035220116,0.00018964088,-0.05497738,0.08033175,-0.015087044,0.04248316,-0.06964326,0.002175795,-0.04371326,-0.038276963,0.06268376,0.040974885,0.021496192,-0.12551686,0.02850171,0.0011618129,0.062723726,0.07389808,0.046861496,-0.08273666,0.06869695,0.011395855,0.0017489969,-0.058422286,0.047099866,-0.0023849688,-0.065454334,-0.07846876,0.050340623,-0.016748415,-0.0042446256,-0.04027369,0.012318659,-0.0233354,0.051152352,0.079955496,0.09528537,0.01938246,0.104902565,-0.045094986,0.0504445,-0.01171819,-0.047813307,0.022514364,-0.08574385,0.0070247813,0.026031101,0.057287965,-0.029623626,-0.04678911,0.050487578,-0.06856618,0.013123822,0.010125234,0.022451585,-0.03725697,0.015364434,0.0023678017,0.02293851,-0.06967896,0.028870467,0.03119932,-0.015558004,0.04261653,0.0034670494,0.04520037,-0.044331174,0.044673745,-0.014958354,-0.037367184,-0.08176152,0.016967276,-0.018489096,-0.0035529165,-0.002521345,-0.050525256,-0.024392068,-0.01853752,-0.034894094,-0.051140558,0.057263732,-0.018543769,0.03640687,-0.037108548,-0.01921095,0.03323591,0.113565944,0.0040142387,-3.4831338e-08,0.091476835,-0.019901501,-0.010512523,-0.104607604,-0.09272271,-0.019993745,0.009383729,-0.05745286,-0.011882114,-0.015130614,0.08936938,0.018607894,0.002734385,0.052842077,0.065640695,0.059545532,-0.005799478,0.038708508,-0.019407917,0.020601492,-0.089472935,0.07322279,-0.099566445,0.06490337,0.017424336,-0.00097456336,0.096648715,0.0025190457,-0.027364684,0.051123414,-0.015329251,-0.008377281,-0.06285835,0.016692862,0.064513326,0.089034624,-0.10930084,0.0061354693,-0.015659915,0.0092336135,-0.027309489,-0.026847653,-0.10244448,-0.03257524,-0.03950845,-0.014369764,-0.032973368,0.008600842,-0.034866236,-0.051174853,0.010022746,-0.024897825,-0.018737983,-0.09377458,-0.10650459,0.041051567,0.0060174656,-0.10143549,-0.0004262818,-0.10128442,0.07903145,0.0060761827,0.14720754,0.0944255 +3.4.14.5,"A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated EC 3.4.14.11 Xaa-Pro dipeptidyl-peptidase of lactococci",384,1.0,-0.045843184,-0.0481979,-0.110964306,-0.03678786,0.034191217,0.09048991,0.03548958,0.16502309,0.06603988,-0.0021842301,0.05590714,-0.0051933443,-0.030759178,0.07827248,0.022151778,-0.03433231,-0.10311886,-0.022035854,-0.058542885,-0.07039706,-0.00065687275,-0.0015275958,-0.015300589,0.054780375,-0.019619176,-0.01935796,0.024340933,-0.024180433,-0.039739978,-0.039595366,0.03323836,-0.11186604,0.0067136195,-0.010071399,0.0495365,-0.030138843,-0.006588515,-0.084022835,0.05181027,0.0027732388,0.104427315,-0.022796484,-0.03803621,-0.057596795,-0.009046641,0.045074474,0.03259472,0.05888114,0.0544044,0.00678897,0.011954615,-0.067298226,-0.04709256,-0.0044930973,0.020455996,0.10646251,-0.041353922,-0.08246879,0.11175584,-0.031530503,-0.053543717,0.051446244,0.0914368,0.033595502,-0.012932197,-0.09456719,0.0021408256,-0.0014288819,-0.0301998,0.044990264,-0.009610799,-0.037134618,-0.016851855,0.021559967,0.06421044,-0.015634442,-0.037881736,-0.041956242,-0.04651555,0.0127829015,0.034563933,-0.010542751,-0.023969214,0.08361093,-0.031642094,-0.041969787,0.09172154,-0.05100221,0.008176123,-0.051360648,-0.03931531,-0.104878,0.02678058,0.005271237,-0.11563709,-0.0666049,0.019515218,-0.03771281,-0.017506614,0.012520955,-0.003899701,-0.064811975,0.017051369,-0.05329431,-0.024330903,0.06948323,-0.0098083485,0.084568284,0.06437129,-0.008066935,-0.034686416,-0.056346096,0.033512942,-0.019538667,0.0017009819,0.019475771,0.022650793,-0.04626677,0.07063015,-0.023316707,0.0594895,0.0009900279,0.004950265,0.04778371,0.055797935,0.072626695,-0.035259567,1.4829233e-33,-0.0017322616,-0.029552665,0.09783549,0.044781588,-0.028121272,0.035599098,-0.02806761,-0.035124123,0.037416644,-0.053019464,-0.08625879,-0.020438304,-0.03284164,0.08706362,-0.03553212,0.04163311,-0.10023764,0.038210545,0.00090233376,0.03418928,-0.079261936,0.07053445,0.009605868,-0.0282687,0.10692398,-0.017296553,-0.015823562,-0.034986686,0.04217307,0.0034593781,-0.035831112,-0.031327985,-0.08777824,0.07265223,0.008922953,0.02533007,0.067828774,-0.10055929,-0.0057346374,0.007637955,-0.048949927,-0.038461115,-0.038712554,-0.07119491,0.06891124,0.0063290247,-0.025582828,-0.008385119,-0.07875407,-0.013969473,0.054057337,-0.08444898,0.047470536,0.021996554,-0.007093614,-0.013699454,-0.06547536,0.073650286,0.09270886,0.10431599,0.084818564,0.07401464,-0.0667548,0.005912606,0.07920297,0.03545898,-0.02924117,-0.03479845,0.050783638,0.015616913,-0.024426056,-0.004652641,0.0483339,0.021056699,0.019358212,-0.053736437,-0.07140478,0.054553013,-0.0141808465,0.07321051,0.062048208,-0.0039796946,0.015177132,-0.023522215,-0.063859195,-0.04336277,0.032205094,-0.027890423,-0.091442354,-0.014653477,0.019842103,0.037370782,0.0050762515,0.006347701,-0.06063825,-4.0199493e-33,0.043459397,-0.13369566,0.058637947,-0.010777614,-0.065452,0.027517058,0.04959892,0.08473227,0.011227245,-0.04060436,0.026444327,-0.055688035,0.034119517,-0.09505118,0.056216646,0.00026447308,-0.08326626,0.046599828,-0.0303419,0.047091376,-0.053948004,-0.0008060645,0.032605354,0.045014378,0.03031262,-0.012091868,-0.028797083,0.06987145,0.021450363,-0.024837803,-0.055708483,-0.016475448,-0.08165716,-0.070922256,-0.046873022,-0.03599836,-0.006615678,0.013208827,0.046130206,-0.0842283,-0.02454589,0.0230644,0.04400182,0.019954465,0.041466326,0.07473987,-0.049817692,0.035664253,0.038873278,-0.0075388225,-0.056472927,-0.038117256,0.03849772,0.014076879,0.023909878,0.012816409,0.007975461,-0.0226025,0.08277106,0.02415614,0.021022538,-0.032840177,0.02549489,0.037938155,0.055177566,0.016352283,-0.074722655,-0.08081799,0.07796931,0.0041100862,0.094230264,-0.01091017,-0.051254228,0.008226888,-0.0011439476,0.020111214,-0.082482584,-0.018595861,0.017224438,0.043529097,-0.015541406,-0.07484652,0.029193325,0.015484892,0.05447001,-0.019566363,0.032631706,0.10730041,0.05391081,0.021638516,0.029238483,-0.07211282,0.006680055,0.08328122,0.04715779,-4.0330047e-08,0.06274739,-0.06537021,0.0021861647,-0.086421415,-0.08846665,-0.025198882,-0.015976524,-0.08390953,0.07022635,0.032752138,0.051819056,0.050369933,-0.012665452,0.043776963,0.044393983,0.064867646,-0.016593697,0.029229907,0.029794894,0.03162936,-0.060593948,-0.04069178,-0.07175573,0.013813748,0.04661324,-0.063162886,0.035842795,0.0591475,-0.028891018,-0.07503769,-0.011779264,-0.010744165,-0.06796286,-0.025796331,0.04857467,0.04187253,-0.02675833,-0.019140292,0.048470803,-0.034012664,0.004402862,-0.041546866,-0.0027633337,-0.07221734,0.041900158,0.001173353,0.043298174,-0.022958022,-0.086996734,-0.04016764,-0.04085675,0.0011389235,-0.037591252,-0.051822122,-0.10008225,-0.0069575273,-0.057272278,-0.056751866,-0.044191707,-0.07152912,0.068502486,0.077531844,0.11845535,0.041302916 +3.4.14.6,"A thiol-activated peptidase from cabbage (Brassica oleracea). Tetrapeptides are formed from Ala-Ala, Gly-Gly, Ala-Gly and Gly-Ala",384,1.0,-0.031202314,-0.026570572,-0.11318288,-0.020527879,0.048017487,0.08301187,0.03167278,0.0796289,0.040312994,0.034572035,0.081107214,-0.063998215,-0.0018793554,-0.09979321,0.011846976,-0.03470787,0.024918297,-0.0041335314,-0.0054246723,-0.13637273,-0.04374619,0.061283905,-0.014255596,0.023696346,-0.04555588,0.019535169,-0.032526538,-0.04398094,0.06185617,-0.03887104,-0.008517146,-0.037558325,0.015666075,-0.051392026,0.00825708,0.02111145,-0.0826963,-0.029021047,0.037920527,-0.024268165,0.037463278,-0.02927337,-0.07701869,-0.033363625,-0.023240846,0.0032626952,-0.046038117,0.12504153,-0.00484429,-0.024843903,0.036975402,-0.050794885,-0.049350765,0.06181596,-0.0549734,-0.030956792,0.006269274,0.039871704,0.057743542,0.043932997,0.047000047,0.02055638,0.036312696,-0.0005616402,-0.13853282,0.0052843024,-0.035009008,-0.023167305,0.041912563,-0.008879819,-0.0077150646,-0.0011583656,-0.04259429,0.06029364,0.010867637,0.028950661,0.011491054,-0.067531794,-0.020424247,0.018408068,-0.021040667,0.026469752,0.014487216,0.102263466,0.0003863464,-0.04754389,-0.0045148614,0.076998875,0.023860436,-0.04338129,0.1387347,-0.02105304,0.056047432,0.0034901367,-0.05464412,0.02144713,0.017283855,-0.118029,0.036325578,-0.0135576455,-0.046882052,-0.025386952,-0.06721868,-0.060481507,-0.09264101,0.120098315,-0.05120743,-0.030960962,0.07967543,-0.0008048245,0.005970998,-0.05694044,0.0027334779,-0.09173684,-0.072518386,0.004641398,-0.004539014,-0.036360316,0.052290853,-0.04905534,0.042429656,0.0036092093,0.024519518,0.049320593,0.018265776,0.038867436,-0.02920037,1.1858546e-33,0.06444443,0.008415797,0.04543647,-0.0026379707,0.03793361,-0.010172769,0.01578924,-0.07432324,0.066619314,-0.019182043,-0.09098384,-0.06982003,-0.07334253,0.0067369062,0.009163688,-0.013363508,-0.063220836,0.0058201314,0.06430383,0.025431134,-0.056881078,0.09644144,-0.015591,-0.023276174,0.030555973,0.06500316,0.028164366,0.00038402388,0.029506302,-0.0034736963,0.003171452,-0.057800166,-0.078740716,8.044628e-05,0.009417761,-0.02502972,-0.011613746,-0.023944693,0.02204345,0.051045544,0.036688924,0.024184648,0.025844326,-0.0238743,0.08222053,0.013549608,-0.022365805,0.022448659,0.049962908,-0.011352885,0.04967792,-0.04347141,0.08404896,0.005322934,-0.058073882,0.03911271,0.017067667,0.060464058,0.10381981,0.04235299,0.026651414,0.07188945,0.011245291,-0.012076459,-0.0195521,0.01589175,-0.09528569,0.0037447012,-0.010594151,0.025799394,-0.014322076,0.012948799,0.084282935,-0.0182777,0.07902377,-0.060656235,-0.025841093,0.051968947,-0.012717925,0.017153945,0.04253607,-0.00021530624,0.011843898,0.004634853,-0.017917128,-0.02470926,-0.07083163,-0.030227615,-0.016753102,0.029873345,-0.013245726,0.029361436,-0.043777525,0.05978815,-0.06637319,-1.1728172e-33,0.04873566,-0.04757722,0.07579894,0.013741603,-0.015514852,0.03001289,-0.075856686,0.00074062165,0.052944638,0.03143117,0.030210286,0.0019405533,-0.04219609,-0.0873364,0.0077405814,0.008926767,0.057761356,0.12874228,-0.082113855,-0.05029969,-0.121379144,-0.07958315,0.004499591,-0.042413615,0.039772924,0.022136614,0.009485814,0.04320398,0.099580675,-0.013799912,0.018289473,0.009550894,-0.08682907,-0.024886109,-0.08073219,-0.008205231,-0.05127299,0.0013112059,0.06431074,0.024179833,0.013954744,0.03350021,0.10708196,0.045503695,0.000107476546,0.030391756,-0.017042777,0.0019133746,-0.06546066,-0.023730217,0.04146275,-0.057022363,0.019326221,0.019143956,0.07144726,-0.0032733127,0.008663091,0.01012448,0.023562115,-0.03969012,0.03957778,-0.029879527,0.035744485,0.016840208,0.03559328,0.07346751,-0.06096199,0.038234383,0.07502891,0.05763031,0.04148705,0.017486213,0.006146213,-0.06555935,0.024706524,0.040041223,-0.0581442,-0.057288565,-0.003232268,-0.039578233,0.0022413812,-0.031836182,-0.032148127,-0.03444895,-0.015933014,-0.009362931,-0.06601047,0.12893799,0.07545504,0.10168053,-0.0773705,0.03249676,0.06945111,0.1234593,0.12962408,-3.1491982e-08,0.037934836,-0.05603928,-0.067689784,-0.0022659232,-0.059821796,-0.052529894,0.01087616,-0.01991557,-0.007794996,-0.111550026,0.007579793,0.035042934,-0.017887997,0.019097535,0.021990385,0.100668885,-0.010360576,-0.021632154,0.042308275,0.0616,-0.07606849,0.0020420854,0.009580768,-0.028293533,-0.053809363,-0.018831708,0.07678182,-0.013675544,0.036371514,0.03481871,0.0012975833,0.026279664,-0.10151659,-0.054213755,0.055772733,-7.244832e-05,-0.094067186,-0.012529493,0.010858592,-0.04096268,-0.03004791,0.021339547,-0.082676485,-0.007628381,-0.038871724,-0.060386818,-0.024056993,0.117211275,-0.053775232,-0.06819508,-0.03301055,-0.03388635,-0.03650525,-0.060570367,-0.063178346,0.009560756,0.05751377,-0.030987063,0.029487189,-0.112015046,-0.04486198,0.03707703,0.15937634,0.108451046 +3.4.14.9,A lysosomal enzyme that is active at acidic pH. Deficient in classical late-infantile neuronal ceroid lipofuscinosis brain tissue. Belongs in peptidase family S53. Formerly included in EC 3.4.14.8.,384,1.0,-0.043464683,-0.108665556,-0.06978163,-0.037637055,0.008394214,0.0019627605,-0.025671992,0.051244155,0.013517932,0.03885668,0.05535089,-0.072478294,0.022129757,0.02374685,-0.022520358,0.00014811776,-0.12654601,-0.089041345,0.01442911,-0.060130596,0.005509281,0.09454596,0.04447326,0.042127553,-0.022617271,-0.025602557,0.04665142,-0.019543754,-0.0500615,-0.06834962,0.051591877,-0.037758384,0.024960265,-0.0084887445,0.02984884,0.02897065,-0.049589854,-0.010360004,0.020305151,0.026916152,0.031463612,-0.076997556,-0.068940364,0.023852075,-0.012951311,0.0005692909,-0.027144274,-0.01305219,0.023170702,0.020713272,-0.021475444,-0.10619348,-0.047330305,0.029190427,-0.08382908,0.0051989653,-0.07794578,0.03983083,-0.004492539,0.052789632,0.062935494,-0.007146613,0.02589269,0.013152635,0.047308475,-0.051187273,0.06255805,-0.12009303,-0.042985342,0.01721645,0.007779415,-0.08820034,0.0031951838,0.09196046,0.03050614,0.03702757,0.027338475,-0.059995458,0.0059626056,-0.08478061,-0.015839076,-0.015598041,-0.036098234,0.13117963,0.0869364,-0.041032035,0.047786828,0.05635011,0.017310979,-0.01777509,0.0027987566,-0.06277355,-0.0021167258,0.018405776,-0.12729554,0.030091546,-0.012533107,-0.03298808,-0.010608903,0.009431504,-0.0018982348,-0.0048299427,0.011904523,0.018370021,-0.010204,0.09113458,-0.027241023,0.014641736,-0.05360745,-0.041140508,0.021118617,-0.027926262,0.010529933,-0.042601835,0.0054124696,0.031009179,0.023782082,-0.03298652,0.013918311,-0.018023005,0.012954246,0.009714773,0.006237716,0.00043550346,-0.047868744,0.032431055,-0.09575812,2.9468012e-33,0.01411307,-0.04081795,-0.032498173,-0.06168504,-0.034842122,0.017106127,-0.004327534,0.014316767,-0.06188765,-0.06982065,-0.018453427,-0.039446913,0.054297727,-0.027332135,-0.064585306,0.033503123,-0.05148138,0.006572489,0.0380965,0.004640566,-0.035072614,-0.008195385,-0.014287424,-0.037087273,0.082330704,0.032725394,-0.026135158,0.0061469222,0.080898635,0.018682832,-0.10026363,-0.08572238,-0.04952888,-0.02620545,-0.02274663,0.04904647,0.040099345,-0.030214764,-0.01808809,0.015132146,-0.006166417,0.018423406,0.020846147,-0.019649241,-0.031926095,0.033392593,-0.059709758,0.009106805,0.03256796,-0.04694917,0.06291957,-0.09912283,0.094097264,-0.026699532,-0.020708282,0.03069073,-0.045428038,0.062026132,0.030064125,0.013499575,0.09064165,0.031371422,-0.07659075,0.073765405,0.0312373,-0.0066588805,-0.06347863,-0.04763979,-0.031497996,-0.034371264,-0.009810327,-0.026655225,0.13083272,0.0032172457,-0.012107489,-0.048185274,0.04663716,0.0360035,-0.06475853,0.050262924,-0.014637893,-0.068925984,-0.020044519,-0.030447103,0.00077668997,0.023165178,0.048998624,-0.0055933516,-0.06385092,-0.003290359,0.025596531,-0.069587424,0.032815274,0.06347761,-0.081617534,-3.710903e-33,-0.013571068,-0.03719417,0.09745894,-0.0051850933,0.0343449,0.05111639,0.0465543,0.04799803,0.012326503,-0.017760616,0.016618058,-0.018995767,0.030529704,-0.108922146,0.091118395,0.049361225,-0.0834727,0.026225483,0.026392728,0.013834089,-0.02607391,0.13941936,-0.03944372,0.10329334,0.0030797662,0.011030128,-0.05467182,0.09440988,-0.037563216,0.006239772,-0.08775136,0.013776231,-0.02796067,-0.043124817,0.025367668,0.010793087,0.0021861482,-0.023093168,-0.007224189,-0.012169889,-0.014908344,0.04116264,0.04108968,0.10745563,0.081600636,0.09350839,0.0039124824,0.07283779,-0.0038748302,0.0041049975,0.013543806,-0.014517832,-0.04425826,0.05656041,0.0013091853,0.06390461,-0.012120384,0.05211602,0.038278174,-0.03222186,-0.02298495,-0.11586534,-0.060224522,0.020379758,0.046118367,0.055750333,-0.1271157,0.021535382,0.059131168,0.038577206,0.029691927,-0.025200315,-0.024295352,-0.021712098,-0.011081919,0.057281636,-0.11169963,-0.061630573,0.0013673798,0.016550481,0.024620805,0.009723182,0.03385352,-0.009520203,0.08519614,-0.049443718,0.015009095,-0.000101944344,0.0012471672,-0.024963766,0.008063076,-0.06337897,-0.060019754,0.034255695,0.046344604,-3.4558255e-08,0.15289155,-0.03551255,-0.010437405,-0.034344234,0.078683704,-0.09657312,0.028084002,0.02669362,0.08287336,0.015095423,-0.01773324,0.03964305,0.0104631735,0.039320923,-0.0035784345,0.13705966,0.006908365,0.14118361,-0.021077521,-0.01173213,0.0069093984,-0.015782252,-0.012730747,0.037820954,-0.0066947825,-0.0025280542,0.0076066735,0.06529286,-0.046411272,-0.086062014,-0.021476254,0.02399094,-0.0042930758,0.01711407,0.033348843,-0.001434679,0.014306175,-0.057656385,-0.04520947,0.10760511,0.063849434,-0.031839814,-0.033095032,0.014203714,-0.042102735,-0.018889323,0.012485446,-0.009043445,0.03438129,-0.023273353,-0.011290644,-0.008913489,-0.021782316,-0.04813495,-0.06608551,-0.010010904,-0.025942057,-0.0015903417,-0.034979455,-0.1097031,0.08538278,0.117401786,0.24823987,-0.018412532 +3.4.14.10,A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8,384,1.0,-0.085997604,-0.038816027,-0.051812675,-0.0547221,0.05597971,0.041422784,-0.038204443,0.11577627,0.03795659,0.040466763,0.05478468,0.0025058344,0.030563613,0.09955625,-0.058797088,-0.0029354554,-0.044751428,-0.028695747,-0.04519869,-0.10756561,0.10435588,0.036307435,-0.020195732,0.07566163,-0.041756663,-0.009127328,0.028236838,-0.011479899,-0.0016371747,-0.004595645,-0.0018421814,-0.026704578,0.13535069,-0.043496713,0.04827955,0.04661293,0.013338452,-0.052045207,0.082033776,0.042663686,0.03820406,0.007805338,-0.012240425,-0.08036534,0.08491425,-0.055813804,0.020560438,0.016300913,0.06276982,-0.0019344316,-0.031489324,-0.044553928,-0.02711581,0.032262642,-0.0051500606,0.04028177,-0.015310926,-0.045234237,0.016263025,0.022540882,0.014469487,-0.021929836,0.044416755,0.007882008,0.0074247597,-0.029804723,0.0004579383,-0.028810233,0.0030774572,0.036714118,-0.03755524,-0.0271663,-0.05988458,0.0803337,0.009899131,0.07149685,0.0070500625,-0.07587003,-0.07958663,-0.08734608,0.057776924,-0.056968197,0.08539155,0.09410391,0.05010474,-0.031338885,0.04701492,-0.03659532,0.04137951,-0.039300065,0.00912541,-0.07193267,0.0344718,-0.0020301181,-0.069794446,0.0020316653,-0.037376184,-0.0390198,-0.0020767062,0.043995056,0.08388995,0.031756483,-0.05361906,-0.014760501,-0.018405821,0.069529906,-0.020960938,0.03846667,0.02981745,0.010648022,-0.031562928,-0.006496645,0.02538698,-0.05287457,-0.04313641,0.03974177,0.04331614,0.018817363,0.00048372016,0.013699377,0.057619207,-0.013730872,0.044463247,0.07207515,-0.029092554,0.01681833,-0.13296576,4.077742e-33,0.0013383401,-0.0022430918,0.05452485,0.05260867,-0.02273599,-0.027524509,-0.0776147,-0.0132005075,-0.061458416,-0.06765398,-0.0839217,0.015328103,-0.0060067824,-0.041719306,-0.06733898,-0.0010466487,0.030154977,-0.028262062,-0.0018107698,-0.043465298,0.045525663,0.023848569,-0.021201646,-0.08766721,0.08086735,0.02536492,0.0075469674,-6.948765e-05,0.067470476,-0.022139926,-0.038611706,-0.015915044,-0.12498825,-0.0042303638,-0.011651228,-0.04704236,0.006479399,-0.095708214,-0.022816649,0.026327103,-0.013875094,-0.006206869,0.011678385,-0.07747445,0.085729726,-0.049184665,-0.08443797,0.032412592,0.036979187,0.057017095,0.034963813,-0.030206556,0.045089822,-0.02632175,-0.07962146,-0.019754555,0.012448146,-0.036889605,0.11116058,0.04637893,0.04847155,-0.021790111,-0.067215376,-8.017637e-05,-0.047419317,0.025168119,-0.060851555,-0.04220363,0.007902847,0.0845458,-0.051644526,0.050428506,0.03630321,0.088961534,0.0055060587,-0.12117044,-0.029600246,0.05680921,-0.0031290487,0.13111536,0.015981078,-0.05211325,-0.023445776,0.030394353,-0.04653711,-0.03794602,0.03484647,-0.006066887,-0.049002852,-0.016183186,0.027898336,-0.09013518,-0.0078069414,0.076770924,0.0018828381,-4.7125785e-33,0.09475687,-0.04407752,0.023363076,-0.066782355,-0.051115565,0.0054712733,0.043268867,0.03348472,0.049077056,-0.004135029,0.034211665,-0.043068346,0.054004684,-0.07848631,0.008677884,0.042513385,0.018266294,0.027794326,-0.015973981,0.035729297,-0.11029107,0.07113508,0.055780217,0.07383425,0.043807507,-0.02832888,-0.016045146,0.104230665,-0.037425667,0.021625677,-0.08866056,0.020190323,-0.09156853,-0.037648134,-0.05850507,-6.439562e-05,-0.0545511,-0.026477454,-0.00808836,-0.09408292,0.019384047,0.110321164,0.07594634,0.11861702,0.025721475,0.13722159,-0.032658152,0.038432818,-0.027345331,-0.018742602,-0.032734,-0.037727516,0.008693956,0.03391624,0.08448564,-0.038662225,-0.026205542,0.04974303,-0.0032963448,0.04417479,0.021872664,-0.03441345,-0.046395943,-0.009071026,0.0064532096,0.10224678,-0.1062864,0.035045963,0.09075377,-0.013318909,0.09673726,-0.024452208,0.041587505,0.000945355,-0.004333595,0.053632956,-0.09020576,-0.0353422,0.0041815666,-0.061074678,-0.023835132,-0.032424215,-0.06546789,-0.037528303,-0.041539386,-0.07977347,0.027204925,0.05725479,0.016064776,-0.0075815204,0.019549686,-0.026778731,0.058899704,0.03285371,0.04853648,-3.5047172e-08,0.07247014,-0.051586546,0.020571902,-0.08768056,-0.0070814793,-0.0056526535,0.027934674,-0.019215351,0.054565098,-0.040451307,-0.0009787803,-0.012093859,0.026366815,0.010046421,0.0021020584,0.09854307,0.0005862822,0.117931254,-0.00013372795,0.05711441,-0.028190602,0.042822473,-0.087525815,0.04784988,0.0034141114,-0.028068412,0.033021163,-0.0018286636,-0.042263713,-0.06882717,-0.004239962,0.009458748,-0.03157139,0.033880193,-0.032332376,0.067428984,-0.02662518,0.027724182,-0.039898176,-0.005325624,0.042973407,-0.072078176,-0.057772283,-0.058990993,-0.026919585,0.013652928,0.016428376,0.031547938,0.008200892,-0.022804132,0.034784693,-0.0325906,-0.008390428,-0.086432666,-0.094357304,-0.022197513,0.023543274,-0.080378585,-0.00035790371,-0.050423767,0.040083982,-0.055141106,0.16315983,0.0061022113 +3.4.14.11,The intracellular enzyme from Lactococcus lactis (190-kDa) is the type example of peptidase family S15. The reaction is similar to that catalysed by dipeptidyl-peptidase IV of animals,384,1.0,-0.02757341,-0.11586192,-0.09069768,-0.05850064,0.054270424,0.05349405,-0.09630591,0.106369875,0.03462485,0.04518596,0.043278378,-0.019498525,-0.011563087,0.08628266,-0.02109569,-0.037975043,-0.08418953,-0.031145442,0.045207392,-0.049904935,0.0318652,-0.0020697392,-0.038659386,0.043984093,0.011122235,-0.021342156,0.0689137,-0.045116104,-0.032176413,-0.03454199,0.008031879,-0.07892851,0.051178258,-0.09009513,0.06937038,-0.021181282,-0.015317488,-0.06854305,0.110523805,-0.036192264,0.040507402,0.027776755,0.0012482185,-0.05857421,0.057633754,-0.03880242,0.00079104153,0.08632324,0.0733724,-0.06363717,-0.024998818,-0.05156855,-0.04698865,0.03777162,0.028023766,0.016440775,-0.07287366,-0.076956354,0.10899769,-0.0023081908,0.008347935,0.02740395,0.027376952,-0.0016838029,-0.04030172,-0.04956479,0.00964472,-0.040143374,0.0028749164,-0.02936897,-0.05863536,-0.09186184,-0.06871383,0.013745582,-0.009454481,0.056000896,0.022303909,-0.05271755,-0.014202111,0.03514812,-0.03785322,-0.008558676,-0.014216351,0.05271396,0.013911183,-0.048579063,0.12591404,-0.013097824,0.059166845,-0.01501148,-0.019549564,-0.08116799,0.018273624,-0.024828672,-0.09500378,-0.04130207,-0.023769842,-0.010064006,0.04844668,-0.034205843,-0.0052542486,-0.0054136235,-0.010958083,-0.07214315,-0.0582335,0.09670361,0.012771516,0.03695778,0.108491994,0.014747395,-0.050142616,0.03547224,-0.05158405,-0.03627194,-0.011524222,0.046386916,0.055850964,-0.09731443,0.0018963129,0.030080743,0.021058045,-0.033002507,0.024914803,0.052368328,-0.025642829,0.03663521,-0.0039230622,1.5225959e-33,0.023674613,-0.032715622,0.050413787,-0.005800336,0.032720447,-0.010306145,-0.041625414,0.0018387793,0.005027594,-0.037133444,-0.09026827,-0.051424637,0.016446846,0.013433234,-0.060674,0.061392024,-0.016970577,-0.04329698,0.0005371154,0.039696936,-0.073891446,0.09745643,0.016634112,-0.008476275,0.118597254,0.024132673,0.019445779,0.026441282,0.05280286,0.011627247,-0.017044304,-0.08305848,-0.106570534,0.042408574,-0.010519164,0.03367582,0.08904993,-0.06862559,0.050355244,0.031849287,-0.011712978,-0.0011117236,-0.017638791,-0.021461818,0.053073313,0.0058981474,-0.053811986,0.040261142,-0.035901465,0.01572662,0.009467899,-0.018045431,0.041049335,0.002277167,-0.037319165,0.043646492,-0.018070528,0.030793115,0.13331136,0.09918528,0.050085742,0.015489869,0.015247564,0.06386888,0.039790362,0.04156199,-0.030400248,-0.011892692,0.016107723,0.07184088,-0.1130406,0.044880312,-0.016938958,-0.015051037,0.03753854,-0.08446222,-0.012696346,0.025205303,0.020661429,0.06514705,-0.01553185,0.0022398138,0.015903605,0.015117851,-0.037641317,-0.022755167,-0.090607546,-0.014743005,-0.038712397,0.021946313,0.011163625,-0.018843986,0.008891657,0.08214784,0.026945136,-3.6772402e-33,0.093554795,-0.12954916,0.052768387,-0.11948744,-0.08256168,0.03304114,0.0554589,0.053829424,0.047958497,0.0060516605,0.0053464766,-0.07448658,0.008680149,-0.027698455,-0.017665252,0.015379042,0.002747653,0.06072891,-0.0546395,0.026278269,-0.039380092,0.072685555,0.042843174,7.344394e-05,0.052953664,0.039912257,-0.07578307,0.07764177,-0.046672173,-0.03841834,-0.015184534,0.004392145,-0.013525469,-0.07603597,-0.08841186,0.03558205,-0.00235543,-0.02766983,0.0013315714,-0.039584596,0.015349981,0.085620746,0.044061065,0.07579855,-0.04807847,0.013414388,-0.07870184,-0.014426378,0.040919673,-0.05720756,-0.018945822,-0.03929647,0.030373342,0.022253003,0.05343019,-0.003962869,0.06873644,0.039354898,0.027622074,-0.0033274381,0.0077583888,-0.043231923,0.013504687,-0.051562995,0.08491593,0.010707003,-0.13481532,-0.110962234,0.08250638,-0.0069218925,0.032966394,0.03175937,-0.027101852,0.034354065,-0.040594175,0.05673035,-0.04999405,-0.09555067,0.03253073,-0.05469268,0.03701266,-0.028165262,-0.017778145,0.027088813,-0.02919877,-0.04452202,0.0049863406,0.08730966,0.041875534,0.047757518,-0.0007029293,-0.050945222,0.03770636,0.076889634,0.06902552,-3.2757452e-08,0.05414931,-0.035534456,0.012755965,0.014939199,-0.09096945,0.018072559,-0.07181518,-0.05000013,0.07938186,-0.07884167,0.024965921,0.06322584,0.019664368,0.021143174,0.0075550405,0.028236654,-0.029669886,-0.026933286,0.012607195,0.06590859,-0.069993995,0.0039203977,-0.05846354,0.049124144,0.020751145,-0.09409518,0.006842532,0.08234192,-0.08908698,-0.08446912,-0.021338057,0.008588462,-0.06842006,-0.0132726235,0.016780611,0.034388535,-0.022463093,-0.02219865,0.039999045,-0.024722287,0.020269377,-0.058930926,-0.07335913,-0.080961116,-0.03847627,0.035320174,-0.03467054,-0.0048300675,-0.031865437,0.025337972,-0.033057537,-0.033108793,-0.023258863,-0.03278306,-0.021256275,0.016041938,0.004221716,-0.08936407,0.0054324,-0.09707013,0.067671746,0.034833435,0.17920439,0.030599495 +3.4.15.1,"A Cl--dependent, zinc glycoprotein that is generally membrane-bound. A potent inhibitor is captopril. Important in elevation of blood pressure, through formation of angiotensin II (vasoconstrictor) and destruction of bradykinin (vasodilator). Two molecular forms exist in mammalian tissues, a widely-distributed somatic form of 150- to 180-kDa that contains two non-identical catalytic sites, and a testicular form of 90- to 100-kDa that contains only a single catalytic site. Type example of peptidase family M2",384,0.99999994,-0.06791571,-0.033115458,-0.12226368,-0.06856797,0.022383913,0.028816355,-0.012885037,0.06249701,0.025653562,0.016843734,0.03319643,0.022535995,-0.008874741,0.0799139,-0.003644668,-0.03596033,-0.047534328,0.03467771,-0.014324788,0.013721545,0.040822234,0.10999187,-0.006348113,-0.025268484,-0.03998376,-0.039771974,0.013462503,0.02170741,0.06945706,-0.056901634,-0.033905838,-0.023705535,0.030340549,0.00558596,0.06816536,0.004717096,-0.033956412,0.005836904,0.011774954,0.0354906,0.05649445,0.021028545,-0.050480235,-0.07545035,0.051301096,0.0032117714,0.002174819,0.021987611,0.021601122,0.023946198,-0.040338848,-0.05446455,-0.03940934,0.06334101,-0.009030079,-0.03168907,-0.17143647,-0.04426637,0.0911657,-0.04456711,-0.0077374806,0.0572789,0.024508268,-0.021500923,0.0086080525,-0.0008274489,-0.010944683,-0.02913412,0.054652706,0.0113716265,0.019488176,-0.017098268,-0.053073347,0.09495047,-0.049005363,0.057545055,-0.044480015,-0.08653815,-0.014220115,-0.017379208,-0.0048552505,0.026774842,0.023446405,0.11234231,0.006558109,0.014146566,0.016413813,0.034993306,-0.017805155,-0.05504346,-0.00059322565,-0.069834836,0.08350049,0.01638218,-0.07630266,0.01081905,0.034574673,-0.047872227,-0.044158187,0.012725073,0.048977353,0.031738214,-0.034238487,-0.012670295,0.050650626,0.041149195,0.055937145,0.0065530515,0.017132333,0.011221157,-0.0353242,0.0034438607,-0.0057639345,-0.013375901,0.007885786,-0.0017285328,0.04536244,0.032816462,-0.020271035,-0.0045532226,0.039857615,0.008805201,-0.015024521,0.013765972,0.024778672,0.066582486,-0.07624716,1.6880839e-33,0.039483547,-0.0055198637,0.09379885,0.047565576,0.014020147,0.033853892,-0.004035003,-0.004000651,-0.0023223863,-0.037188184,-0.092815325,-0.054696105,-0.014684118,0.07967722,-0.073181756,-0.03332033,-0.027499573,0.009144977,0.060120627,0.014565336,0.05188881,0.09881394,0.005732195,-0.02368352,0.03925308,-0.030865615,-0.01807366,0.036999,0.08100894,0.03085164,-0.048046835,-0.05191421,-0.09462487,-0.005771554,0.012300347,-0.041877788,-0.018804897,-0.06750615,0.03346479,0.019522661,-0.033229895,-0.0077025383,-0.09223844,-0.06786267,0.036739204,-0.06478835,-0.08992849,0.062479466,-0.02718325,-0.04576111,-0.009043648,0.0008255386,-0.009619405,0.010049759,-0.11642454,-0.00455948,-0.038762815,0.003518994,0.013752381,0.10510937,0.056341827,0.024474086,-0.03615886,0.088959396,-0.00030704224,0.040701844,-0.121113874,-0.099140875,0.0025700757,0.0703045,-0.050807904,-0.030984113,0.010058716,0.027678553,0.033638265,-0.13372652,0.00615593,0.07436638,0.007491495,0.03701093,-0.0015291285,0.03469794,-0.03310521,0.08401383,-0.059855055,-0.11694607,0.013452945,-0.081004575,-0.07525223,-0.010928908,0.031193605,-0.031490333,-0.052995525,-0.054615404,-0.045379054,-3.6781615e-33,0.04373097,-0.038499516,0.102243215,-0.036653712,-0.01878402,0.029290209,0.050179437,-0.08108462,0.044620566,-0.022397181,0.04623302,0.002191496,0.0200448,-0.066046454,0.0020315782,0.036642823,-0.0019921542,0.027678203,-0.01016214,-0.045377336,-0.09304749,0.041758094,0.08202054,0.03864853,0.003712036,-0.021168273,-0.11615428,0.048305295,-0.007766139,0.06379454,-0.031094477,0.12267601,-0.1215017,-0.10732066,-0.059964374,0.010315767,-0.05458745,0.017508097,-0.017655492,-0.060571156,0.007839547,0.008851757,0.053177964,0.06734685,0.060541686,0.063827746,0.0021074705,-0.02650665,0.050078824,-0.011663633,-0.034188695,0.022783771,-0.0025292067,0.05642454,0.083700426,-0.04301686,0.03256186,0.023194667,0.030085046,0.038263902,0.0032476273,-0.0024572262,-0.03699899,0.023371153,0.06242375,0.027742287,0.027617885,0.0037475736,0.10409924,0.00025802388,0.10716928,-0.008001674,0.089732505,0.017410072,-0.0375341,0.07010489,-0.028507914,-0.06444364,-0.047300234,-0.06797057,-0.038757995,0.00030381218,-0.037624534,0.03917613,-0.054550983,-0.01763831,0.019510318,0.13040216,-0.008019116,0.06701166,-0.031206686,-0.08235432,-0.018188633,0.046832725,0.036814272,-4.7900414e-08,0.039301332,-0.062122952,0.004948205,-0.13560918,-0.16591142,0.040476274,-0.043475345,0.008021982,0.07360166,-0.046521463,0.05601792,0.05919333,0.081880674,0.0131076425,-0.023857245,0.081455074,-0.029721944,0.07900468,-0.012611621,-0.0071931616,-0.040672377,-0.0012895769,-0.10110671,0.06350365,0.047346756,-0.052400697,-0.005255299,0.06581188,-0.05165937,-0.059437122,0.09544235,-0.015989378,0.004666238,-0.012853503,0.014056026,-0.0019368856,-0.00611431,0.010768658,-0.009078585,0.019162612,-0.020291561,-0.027789013,-0.05692209,-0.0047113216,0.041563265,0.013810009,0.0088061225,0.053008758,-0.022904737,-0.006280929,-0.045245208,0.061522834,-0.018997673,-0.091031045,-0.05680511,0.053447157,-0.08881669,-0.057816733,0.002168862,-0.08152341,0.030225864,0.040105876,0.109747365,0.052455876 +3.4.15.4,"A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it displays no Cl- dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II",384,1.0,-0.05561908,-0.053993106,-0.06416527,0.107987955,0.1065494,0.039595947,0.066609964,0.049070086,0.03910577,-0.00954947,-0.024476709,0.0028085152,-0.0013049403,0.074093714,-0.04765131,-0.026907919,-0.03782709,-0.035848785,0.011288294,0.07118485,0.025685716,0.021367885,-0.035695832,-0.03016021,-0.003678722,-0.06526121,-0.04328955,-0.07388188,-0.019172456,-0.015182822,-0.037350267,-0.016889865,-0.018784968,0.043622833,0.07482187,0.06938238,-0.031134548,0.034046803,-0.020644471,-0.009204723,0.14720993,0.04252697,0.00078682275,-0.014529117,0.043770213,0.060430363,0.033811092,-0.02258699,-0.012397284,0.08879846,-0.04546738,-0.021545973,0.03581203,0.0061207847,-0.08573723,0.027524512,-0.08194633,0.009643131,0.059631165,0.0010736306,-0.026842922,-0.06085109,0.020894619,-0.010814991,-0.062232234,-0.032260213,0.010584482,0.008874353,0.03036701,-0.045082778,0.018291598,-0.048669107,0.003738278,0.05436884,0.043385465,0.06206042,0.030039331,-0.026893478,-0.060469065,-0.040035527,0.02070098,-0.033700913,-0.018224385,0.031781018,0.05652838,0.03425097,-0.010452943,0.010243408,-0.040461496,0.023285858,0.06975605,-0.015209146,0.019944139,0.0021574409,-0.0675635,-0.0015043719,0.0086754095,-0.05488409,-0.06067958,0.03142027,0.07545779,0.09799654,-0.024493385,-0.0034336539,0.076057084,0.008559036,-0.0011483064,-0.04298398,0.05197141,0.009010631,0.050029628,0.029468568,0.04300134,-0.011212078,0.1043494,0.07056151,-0.037557535,-0.04052589,0.028568724,0.01891232,0.029257827,-0.019853523,-0.0146576855,0.04865563,-0.038100913,0.016132947,-0.110725895,3.4531524e-33,0.029179974,0.022388265,0.0720005,0.05633689,-0.028654952,-0.018098451,-0.010168061,-0.018315615,0.060410377,0.010393645,-0.14703012,-0.13489014,-0.018687228,0.06580507,-0.0875221,-0.048634265,-0.073471606,-0.030793928,0.055373248,-0.042895105,-0.052704494,-0.021743696,-0.009029412,0.00520755,0.07376459,0.026248174,-0.07574041,-0.0063415496,0.07208348,-0.009111642,0.029219473,-0.011771736,-0.036584884,0.012294137,0.00010378287,-0.043705244,0.02686285,-0.03310048,0.02880779,0.023934279,-0.021188308,-0.0044877855,-0.022157539,0.01862253,0.14420293,-0.1479043,-0.07940265,0.014949896,-0.009919204,0.01952429,0.05718194,-0.06257462,0.07019523,-0.01997166,-0.0750098,-0.027805556,-0.027524011,0.06643524,0.030428085,0.049968813,0.07464698,0.015761057,-0.061246596,-0.00084283063,-0.008808922,0.0725757,-0.08470516,-0.082532816,-0.08208968,0.035863165,-0.023598338,0.018547054,0.031433944,-0.020301407,0.0300421,-0.007354052,-0.08332053,0.1501113,0.08157732,-0.040047146,-0.016326016,0.06875471,0.015075528,0.08579131,-0.04109099,-0.08560908,0.13478932,-0.07143631,-0.014166153,-0.03078993,0.0481747,0.0947818,-0.03819629,-0.082736224,-0.01673537,-3.4954357e-33,0.010973675,-0.025476245,0.030007683,-0.060659043,-0.059110742,0.010089079,-0.027166247,0.021418445,0.017564625,-0.088597484,0.06686294,0.0005903798,0.040175237,-0.028736603,0.023105154,-0.010217135,-0.07357164,0.020270217,0.035176247,0.031844765,-0.031764857,-0.048723076,0.13938604,0.07913833,0.034472317,-0.004235231,-0.0038130896,-0.0066948114,0.06453608,0.06126108,-0.021663828,0.08017522,-0.08064865,-0.095068,-0.0628357,-0.018116161,-0.106714405,0.028790023,-0.049942903,-0.023867486,-0.021642707,-0.03582459,0.035415802,0.005373772,-0.012379927,0.06464838,-0.002414772,0.011113167,-0.016046815,-0.06605288,-0.06653419,-0.05690783,0.05132863,-0.012233457,0.046890296,-0.01280298,0.027761802,0.010569639,-0.009254764,-0.057461344,0.017532626,0.044247895,-0.035586465,-0.046392143,0.07275531,0.06579874,0.028327644,0.06196514,-0.009893288,0.009012925,0.07061296,0.026375426,0.007815366,-0.00046002763,-0.02530352,0.032028243,-0.016864456,-0.018555705,0.00013775843,-0.051621675,-0.031198924,0.100530595,-0.058713064,-0.052903906,-0.007242135,0.0019149769,0.023530006,0.04670596,0.05882707,0.01035866,-0.09604797,0.0040479545,0.011563331,0.0034691438,-0.059529554,-4.1573667e-08,0.056863345,0.027156213,0.0072304737,-0.10243382,-0.099977195,-0.022747217,-0.031339575,-0.06939036,-0.08517475,-0.04058275,0.04160201,0.008421145,0.035747465,-0.04749075,0.045424864,0.05611879,-0.082478344,0.036196765,0.031348992,0.027267363,0.013799451,0.055004165,-0.03787614,0.0138287125,0.13488275,-0.043887906,-0.0010277022,0.056603372,0.008831571,-0.01953677,0.08446262,-0.054028746,0.056278396,0.051496226,0.008371383,0.019568803,-0.0703919,-0.04336596,-0.022809263,-0.02957264,-0.07914343,0.015629154,-0.027037136,-0.029451389,-0.026578736,-0.055864125,0.080509245,0.026472986,0.053701136,-0.028950846,-0.06670631,-0.033814155,-0.042459946,-0.067195944,-0.038688257,-0.045356363,-0.051599808,-0.042072278,0.046165258,-0.096822806,-0.013822954,0.05036228,0.031399257,0.06491735 +3.4.15.5,"Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase in peptidase family M3 (thimet oligopeptidase family). Ac-Ala!Ala-Ala is a good test substrate [3]. Inhibited by captopril, as is peptidyl-dipeptidase A. Formerly EC 3.4.15.3, and included in EC 3.4.15.1, peptidyl-dipeptidase A.",384,0.99999994,-0.110546485,-0.031582996,-0.08441626,0.029584864,0.08004435,0.02937081,0.065131664,0.06272231,0.0415587,0.018133085,0.038198825,-0.0384345,0.012065697,0.076860555,-0.08372767,-0.04879048,-0.017389543,-0.029651042,-0.013101478,-0.0798129,0.03771857,0.04686643,0.04658995,-0.032425843,-0.04364393,-0.0012864072,-0.02038667,-0.017132936,0.048860773,-0.084244624,-0.015533187,-0.048256442,0.054790303,-0.04021699,0.082568936,0.0059898514,-0.017395735,-0.03134077,0.08121284,-0.006937143,0.10029674,0.028365474,0.009407587,-0.030065581,-0.027336067,-0.0011156643,0.012642388,0.070260756,0.0009286815,0.0627071,-0.028844602,-0.08520548,0.025371373,-0.025501266,0.0006091334,0.011816866,-0.013318036,-0.10399674,0.06296116,0.016259689,0.020275658,-0.033941336,0.023673385,-0.0005685074,-0.03406362,0.042773236,0.017896557,-0.04160634,0.061189298,-0.04517468,-0.046216983,-0.0592444,-0.024909122,0.10384225,0.04618922,0.062009472,0.062149823,-0.15708998,0.0044156965,-0.006632364,-0.022909075,-0.004226803,0.049011976,0.07150398,0.08121434,0.013351844,0.0070041344,-0.0011055161,0.00739874,-0.032043353,0.039518844,-0.06515004,-0.0015846533,-0.015556915,-0.08718928,0.018468797,-0.015797708,-0.08799195,-0.045826863,0.060831327,0.028456418,0.044685975,-0.021638365,-0.030726206,-0.020371042,0.018321352,0.06117027,0.007543763,0.028575446,-0.0077378773,0.0017233705,-0.008417773,0.0026788907,-0.046665244,-0.017653354,-0.019403923,0.02270741,-0.057170898,-0.035471883,-0.048079737,0.0011483008,-0.024750954,0.011409069,0.011211609,0.0435054,0.06893692,-0.059039522,4.2893238e-33,0.018198796,0.04021933,0.034166772,0.00023618824,0.04536194,0.0070501175,-0.012754432,0.04795419,0.03887232,-0.021582168,-0.060839698,-0.103316054,-0.014814106,0.008500046,-0.0291298,-0.003857991,-0.07012554,0.026928354,-0.0127315,0.05077553,-0.009969186,0.02990371,0.021799257,-0.023685912,0.085163474,0.03252696,-0.03639025,0.018371038,0.08687416,0.017898884,-0.0013363899,0.016098564,-0.13817704,-0.018941056,0.060206104,-0.037496343,-0.011885109,-0.066794224,0.002290293,0.06052112,-0.06698146,0.03025218,-0.007970604,-0.0020775183,0.09932893,-0.1412494,-0.081615604,0.05927405,0.03387237,-0.0011918156,0.029726245,0.014345781,0.05545831,-0.055807512,-0.077090174,0.01942745,-0.028467517,0.0570873,0.13148664,0.04274833,0.06836022,0.03007108,-0.06902799,0.005083703,-0.013182487,0.05061284,-0.059492555,-0.037979607,0.0010942185,0.032593425,0.026660264,-0.0050838804,-0.0064912443,0.05816573,0.034508206,-0.08234988,-0.04937954,0.042939723,0.09177664,-0.045166362,0.04774357,-0.009501216,0.05413508,0.0014310176,-0.117322735,-0.057098184,0.008728487,-0.019911237,-0.030577822,-0.018548224,-0.0031929251,0.08219128,-0.036185574,-0.030718805,-0.05682042,-3.785564e-33,0.1061948,-0.04201375,0.019077256,-0.084665716,-0.0858944,-0.055219542,0.0051690894,0.04634228,0.06946866,-0.02864688,0.15164948,0.009983985,0.05931201,-0.092182435,0.017958645,0.038653456,-0.0364004,0.052436654,0.019276068,-0.022449128,-0.05569098,0.002337644,0.10187205,0.012632947,0.018382609,0.015051239,-0.038024496,0.04637572,0.055101536,0.047644883,-0.047329146,0.11318175,0.004358162,-0.0749128,-0.09445809,0.006944194,0.00729682,-0.008000768,-0.06983932,-0.0245112,0.04617209,0.018927036,0.030235354,0.089521706,0.014578712,0.10068369,-0.048303187,-0.0019947765,0.016451064,-0.0416843,0.0054980367,-0.032264903,0.048240475,-0.0136892,0.058622744,0.0035948032,0.001282265,-0.039506085,-0.030931909,-0.0034439694,0.0022443063,0.033792265,0.014942453,0.041251015,0.10599429,0.07468418,-0.04438178,0.095530905,0.047923855,0.011126615,0.07599399,0.04686891,-0.022526408,-0.08147604,-0.050713584,0.029475862,-0.037331715,-0.018755974,-0.001982846,-0.043817822,-0.014213583,-0.011529421,-0.064314105,-0.00094987324,-0.030164337,-0.048115686,-0.018449834,0.09350945,-0.039081972,0.080944344,-0.108060494,-0.06914783,-0.003570229,0.059981424,0.036223136,-4.073312e-08,0.032984212,-0.027221432,0.01350349,-0.080318384,-0.08561479,0.02312791,-0.06189186,-0.109920636,0.031635534,-0.08279646,0.0113199735,0.07757358,0.011369236,0.04060142,0.0039052698,0.058320846,-0.057432365,0.025313282,0.004934453,0.025523478,-0.051881053,0.056702986,-0.01164792,-0.0071264687,0.010550051,0.004332101,0.053518686,0.02904887,-0.03829682,-0.021985915,-0.04134339,-0.0034728448,-0.013503955,-0.0018715896,0.036998935,0.06491178,-0.08463993,-0.033519004,-0.023439331,-0.010866124,-0.0409497,0.014688993,-0.069449484,-0.035879016,0.02387853,-0.023555228,-0.011755987,0.055919386,-0.030636,-0.071380295,-0.016643506,-0.04235125,-0.026302025,-0.023210976,-0.09481574,0.011309898,-0.0058541484,-0.12277595,-0.034515418,-0.08824073,0.07194373,-0.016403629,0.18405855,0.033889852 +3.4.16.2,A lysosomal peptidase active at acidic pH that inactivates angiotensin II. Inhibited by diisopropyl fluorophosphate. In peptidase family S28 (Pro-X carboxypeptidase family).,384,1.0,0.008447534,-0.06259596,-0.07329092,-0.028742086,0.10012894,0.039739564,-0.015307066,0.07484575,0.010703514,0.023740908,0.036021594,0.039681517,0.010480196,0.059362672,-0.023646567,-0.020729546,-0.13250789,-0.05144477,0.0036546616,-0.0109755285,0.00040157264,0.05239135,-0.007252569,0.040581588,-0.02450281,-0.054706533,0.05375595,-0.034890156,0.015619087,-0.030491034,0.04165818,-0.06998386,0.068706416,-0.010444471,0.052924313,0.011775547,-0.00823137,-0.019043887,0.039012864,0.028857855,0.08304995,-0.046163693,-0.042861342,-0.08864199,0.04149788,0.06125269,0.054080676,0.054543357,0.03531673,0.024845745,-0.06412862,-0.08111274,-0.07152122,0.024677938,-0.043891422,0.016712997,-0.073691934,0.022181798,0.061111655,-0.0026320834,0.06527568,-0.0012670734,0.031584144,-0.024610324,-0.079253644,-0.04072016,-0.012979977,0.0028805607,0.069617614,-0.010056559,0.054259066,-0.01739034,0.0020590618,0.083887845,0.012371042,0.061442036,-0.021070203,-0.087583266,-0.07818821,-0.043122936,0.024777584,-0.085731044,0.039955452,0.09296465,0.03405562,-0.006604025,0.0029237845,0.052418288,0.028371764,-0.071702056,0.041561987,-0.09297326,0.056942932,0.047814965,-0.06767252,-0.010104535,-0.0076140715,-0.08022826,-0.13116035,0.04051615,0.02319685,0.030427728,0.006261834,-0.0027917065,0.02684129,0.06038394,-0.028120006,-0.0070364457,0.025219932,-0.027269633,0.012859451,0.030941823,0.045982495,-0.059983358,-0.0721737,0.023760226,-0.0065836664,-0.049577374,-0.023194332,0.005285845,0.10013701,-0.010608154,0.012994536,0.051474176,-0.002408254,0.032896318,-0.08681469,4.501285e-33,0.008972862,-0.012079288,0.058825307,0.013657338,0.004612439,0.01150109,-0.03185685,-0.032189935,0.017279565,-0.13250901,-0.07754094,-0.034324653,0.054193705,0.037467603,-0.0737824,0.029241014,-0.07858486,0.003883765,0.035141528,0.039523475,-0.0051491037,0.0053908536,-0.05152394,0.013803187,0.05855959,0.04612036,0.0697417,-0.0026455752,0.111470394,0.02505352,-0.038421445,-0.052372128,-0.06555658,0.027015189,-0.006614076,-0.047542136,0.03500479,-0.11469507,0.008885634,0.02024985,-0.008998725,0.019734504,-0.012801539,-0.059016168,0.08624012,-0.11739058,-0.014083238,0.06628402,-0.04325771,0.07011373,0.0427194,-0.08860089,0.0682065,0.049830988,-0.053360753,-0.02217507,-0.05177797,-0.0029094256,0.04232676,0.043535516,0.081057325,-0.04430177,0.027367303,0.0478383,-0.036376514,0.041214287,-0.09060315,-0.08542708,-0.029879631,0.037474576,-0.056137018,-0.01984015,0.021299513,0.0006705048,-0.0338059,-0.12616454,0.010532009,0.106866404,-0.022507992,0.08311362,0.03723827,-0.0075617516,0.008527857,0.08769546,-0.06424401,-0.0650585,0.03646064,-0.050789725,-0.09590439,-0.03331741,-0.02119224,0.0066869804,-0.015716136,0.07117187,-0.042619176,-4.9959164e-33,0.07560016,-0.040891886,0.022748204,-0.037107162,-0.024160441,0.02713066,0.024568781,-0.008410158,0.052516997,-0.075079516,0.025448343,-0.023782672,-0.017440783,-0.06915656,-0.0016129926,0.0153314015,0.027777879,-0.0022912493,-0.018367955,0.029157694,-0.08807977,0.040085185,0.083767965,0.05667261,0.023244042,-0.01688322,-0.05456814,0.03245971,-0.035258226,0.015613913,-0.010308293,0.025663914,-0.0702677,-0.07934479,-0.07119322,0.039137453,-0.02831733,-0.0380892,0.0076747485,0.016957419,0.042463634,0.03823857,0.047185168,0.042166196,0.02641999,0.09259172,0.008403717,0.00085473165,-0.007675642,-0.06560523,-0.008047532,-0.038940363,0.0074820104,0.07173409,0.062136296,-0.07370128,0.011035441,0.12135052,-0.06259068,0.037593503,0.041378047,-0.06437538,-0.04042914,0.01085055,0.019228382,0.02501579,-0.07433094,0.020475198,0.09374935,0.00023014388,0.07522881,0.008973147,0.042618457,0.015954297,-0.04038178,0.069221586,-0.07661402,-0.08043944,0.006006986,-0.09209632,-0.0650331,-0.03718122,0.019445565,-0.039003205,-0.06393797,-0.01771776,-0.046260078,0.07046615,0.02415402,0.03868744,-0.03725312,-0.069110885,0.07996226,0.053275954,0.079358384,-3.4254192e-08,0.09018376,-0.012170384,-0.04678505,-0.07289,-0.09825597,-0.039009277,-0.05054506,0.02710792,0.031313445,-0.036690347,0.03786691,-0.013968185,0.033888,0.039882984,0.012013374,0.09247574,0.021739868,0.09253142,-0.028757295,0.05580273,-0.03145852,0.033139586,-0.030015448,0.012627629,0.02161568,-0.050297413,0.027527887,-0.018324375,-0.019573962,-0.012861462,0.049802393,-0.038879126,0.023351254,-0.026775187,0.01673257,0.03801404,-0.04495983,0.009427346,0.01952455,-0.0067415885,0.009069689,-0.0027201138,-0.09550524,-0.052571617,-0.020425895,0.00084135437,0.07668733,0.031166986,0.019453634,-0.041740127,0.037405893,0.034949537,-0.026325021,-0.11533235,-0.07935533,-0.005732113,-0.08149659,-0.032207444,0.05561192,-0.13494703,0.04964108,0.077696845,0.11291244,0.04079342 +3.4.16.4,"A membrane-bound, bacterial enzyme inhibited by penicillin and other beta-lactam antibiotics, which acylate the active site serine. Examples are known from peptidase families S11, S12 and S13. Distinct from EC 3.4.17.14, zinc D-Ala-D-Ala carboxypeptidase",384,0.99999994,-0.056391608,-0.053565606,-0.067313,-0.05036625,0.053452723,0.066399224,-0.013166617,0.08509564,0.056497164,-0.033626348,-0.002002076,0.027703386,-0.0043062335,0.12586005,-0.03779787,-0.051779423,-0.051625848,0.04194886,0.008258615,0.018764105,0.062779665,0.07378919,0.023604698,0.0021338214,-0.0118220085,-0.00815819,0.008576795,-0.03945004,-0.0051821657,-0.030038932,-0.02776498,-0.068646245,0.10306971,-0.02179147,0.1141931,-0.029268224,-0.036026277,-0.0132863335,0.08453286,0.024293471,-0.008320717,0.054521337,-0.012777227,-0.038532883,0.051429007,-0.015482512,0.04545799,0.05762456,-0.0038192098,-0.062506445,-0.025389291,-0.059115034,-0.03881231,0.09591695,0.025216576,0.01739356,-0.06286478,-0.0737185,0.009073927,-0.031139232,0.042284016,0.049265806,0.072081916,-0.03340005,-0.019323576,-0.040629353,0.005331691,-0.025154876,0.064399295,0.014446684,-0.070863724,-0.06109915,-0.040713854,0.04798341,0.020021522,-0.005129793,0.017785277,-0.06828892,-0.019942055,-0.0678545,0.013130595,-0.049045913,-0.0069637,0.16394281,0.036983643,-0.06924446,0.058652814,0.015003782,0.076182425,0.01893228,0.04611972,-0.073524214,-0.03405359,-0.005241669,-0.12632109,-0.08302782,-0.024389006,-0.004423455,-0.056146126,0.011377978,0.017291196,0.03981167,0.0065865377,-0.08102945,0.024317984,0.03497264,0.04427149,0.020032369,-0.044344798,-0.012119772,-0.009599146,-0.013776143,-0.037584633,-0.034163687,-0.032363344,-0.02583402,0.04753689,-0.04487209,-0.01523557,0.03818114,0.0045456346,-0.0255751,0.01606036,0.046077196,0.0007448215,0.08979219,-0.11200948,1.7665156e-33,-0.0020269782,-0.040148284,0.030147173,-0.026651824,0.03748338,-0.045544583,-0.06547132,-0.0060766656,0.0059326505,-0.0101470705,-0.09456513,-0.06732421,0.03359593,0.03603995,0.026169676,0.0022992806,-0.073824994,-0.027925868,0.06352061,0.05128797,0.035231084,0.034614965,0.013106106,0.019593721,0.10519927,-0.04818591,-0.018268326,0.031540077,0.12854321,0.0015739881,-0.0031538508,-0.088650845,-0.023478959,0.011759412,0.04132885,0.011078184,0.005684026,-0.08949458,0.0217128,0.030357087,-0.045171794,0.007240487,-0.008777509,-0.025097962,0.08602074,-0.038854703,-0.10607905,0.13241372,-0.008783782,-0.012465033,0.036245476,-0.03154129,-0.017652094,-0.03692249,-0.045971192,0.011753672,-0.049743123,0.07053169,0.042166118,0.07903224,0.06611559,0.0044468055,-0.059127223,0.01771629,0.07438437,0.058992933,-0.063119896,-0.067882374,0.0023879912,0.027210485,-0.12457399,-0.0075675705,0.04646512,0.0915777,0.014215859,-0.07094469,-0.048524644,-0.005664652,0.078863725,0.0025399763,-0.008118769,-0.050530322,0.018996995,0.03242551,-0.071500994,-0.07499568,-0.02541932,-0.0019147613,-0.065076925,-0.058210544,0.010001526,-0.042711157,-0.02172716,0.072516784,-0.060651228,-2.7126193e-33,0.04930383,-0.0847819,0.037031334,-0.041190237,-0.030090349,0.09049843,-0.02004501,-0.027312672,0.055596735,-0.008742999,0.037048575,-0.036821425,0.054040436,-0.030705035,-0.008289951,-0.02079782,-0.042289365,0.011715797,-0.016095895,0.0115058655,-0.043031927,0.01738651,0.01655538,0.059157155,-0.021413734,0.011134574,-0.065463476,0.07858334,-0.02530375,0.041366428,-0.019960413,0.040894236,0.009511497,-0.100524895,-0.15344253,0.1135305,0.01200437,-0.021849625,-0.016774228,0.034140475,0.039096024,-0.0052037677,0.031875983,0.05615243,0.009052673,0.06275361,-0.06491234,0.039572977,0.023755992,-0.0598708,0.0065027312,-0.04209168,0.055050865,-0.012503026,0.06555534,0.006787169,0.020688474,-0.024771178,0.03273863,0.024163868,0.053144626,-0.020107627,0.0048566307,0.025920864,0.03751414,-0.027406627,-0.05837407,0.02732837,0.11853177,-0.034701694,0.05891137,0.044882692,-0.010311168,-0.00014790484,-0.035370313,0.049782034,-0.031325396,-0.054677058,0.037442815,-0.04768406,-0.011205899,-0.0065172524,-0.015914433,0.039579283,-0.0058450736,-0.005469614,0.01618676,0.09347883,0.017506326,0.0633298,-0.040013015,-0.020227538,-0.044721358,0.10776373,-0.00022713284,-3.7319516e-08,0.12736122,0.014605654,0.061036244,-0.035711043,-0.015464751,0.022881223,0.004914511,-0.010253436,0.033997998,-0.05478015,-0.024260707,0.08664313,-0.023559924,-0.011921814,-0.0028755376,0.08712353,-0.09387031,0.051129375,-0.054522388,0.015835552,-0.032209758,0.03538408,-0.06958762,0.022855185,0.044604614,-0.083505,0.0067916973,0.037700776,-0.08054063,-0.015011218,0.0005620462,-0.021931557,0.0010360304,-0.08418655,-0.017466664,0.037074294,-0.08860843,-0.075575195,0.0026212635,0.06636042,0.089067295,-0.036591012,-0.06809121,-0.052149177,0.08479894,0.022241417,-0.0076318695,0.005309015,-0.05978011,-0.010878657,0.06863119,0.021511031,-0.04733825,0.003022754,-0.08482866,0.08170342,-0.042967577,-0.100042835,-0.014191389,-0.076610774,-0.009804818,0.0119060455,0.16694501,0.048578773 +3.4.16.5,"A carboxypeptidase with optimum pH 4.5--6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10.",384,0.99999994,-0.0042482833,-0.048604943,-0.07478825,-0.055835534,0.07009348,0.1347566,-0.019562906,0.087894775,0.0029282246,0.016467202,0.020641137,-0.029746136,-0.044791106,0.08084603,-0.049196515,-0.027451364,-0.02400176,0.008372265,-0.018831896,-0.06755078,0.023684617,0.049115118,0.0053499974,0.043997135,-0.04269985,-0.09921463,0.011992772,-0.035679795,0.0011170339,-0.054599613,0.02606282,-0.09278889,0.08272201,-0.02651734,0.03953328,-0.0035194696,-0.017378941,-0.04595264,0.071272835,-0.007577665,0.03921785,0.03461641,-0.050151996,-0.045150116,0.021190675,0.016991936,0.033188507,0.099657945,0.016326685,-0.031274103,0.019687355,-0.04513845,-0.046827182,-0.014883472,-0.039290152,0.02235123,-0.0037044522,0.0416184,0.059311055,-0.004718983,0.042127356,0.02097834,0.06858839,-0.018640498,-0.011963362,-0.019336702,-0.008441535,0.024831053,0.047422316,0.0397585,0.019541152,-0.028853707,-0.012250673,0.06388736,-0.001010148,0.0636689,-0.052526616,-0.05789652,-0.050297998,-0.010583091,0.01492967,-0.06016484,0.11214798,0.03391392,0.027976854,-0.07655996,0.037264317,0.039884873,0.011051751,-0.030939734,0.08895341,-0.07421844,0.07074047,0.015871493,-0.07387439,-0.024348006,0.017116703,-0.053006962,-0.051765632,-0.014917037,0.07658163,-0.0015991178,-0.03552975,-0.05397522,0.0062419493,0.0831783,-0.0055655222,-0.0035746428,0.016032882,0.015960611,-0.026151141,0.027988413,-0.021168,-0.06768434,-0.07537111,-0.006239457,-0.04320163,-0.053144306,-0.026195388,0.023849698,0.051425908,-0.042347245,0.04086665,0.030510897,-0.0074827387,0.03906745,-0.10123089,2.2807322e-33,-0.01716586,0.010083847,0.04933321,0.012097143,0.04691738,-0.033065893,-0.06713225,0.001773335,-0.005417817,-0.040478513,-0.0824848,-0.07855045,-0.030554246,-0.017943518,-0.041828517,0.01833964,-0.12986155,-0.0036566146,-0.028824093,0.05470167,-0.028718239,0.04029375,-0.016508644,0.015162492,0.06542281,0.044677127,5.031038e-05,-0.0028828369,0.117129326,0.018358208,-0.038740113,-0.06444064,-0.11079905,0.022915784,-0.0036208134,-0.030396199,0.058983278,-0.103152275,0.0036887948,0.0003622722,0.014138103,-0.010243538,0.0030178635,-0.096960634,0.11700177,-0.10160358,-0.018690899,0.05708911,-0.065817155,0.024386618,-0.022490712,-0.057732854,0.034260962,0.025561418,-0.07220061,-0.013613166,-0.049282808,-0.0076330495,0.09626996,0.05923827,0.08565562,0.012587359,-0.029562604,-0.011643272,-0.029081354,0.05399636,-0.10435487,-0.05544136,0.0048037185,0.10226556,0.014433074,-0.030902006,0.056605488,0.024806213,0.027422385,-0.08382513,0.0175912,0.081615485,-0.032707125,0.0513207,0.03786714,-0.010674784,-0.014671335,-0.014357727,-0.013026012,-0.03650799,-0.011774128,0.01531622,-0.058678728,0.018406518,0.05647881,-0.034167964,0.019743824,0.073738635,-0.06582665,-2.4130069e-33,0.045421924,-0.04105237,0.03302329,0.0074957083,-0.008632191,0.066613704,0.005382398,-0.0058801733,0.044196267,-0.05061059,0.0024898532,-0.051598825,0.027246987,-0.06352033,0.02084548,0.006031767,0.0054944046,0.049298767,-0.031054528,-0.019158017,-0.075874805,-0.0096676275,0.030231422,0.08522183,0.03607187,-0.013419187,-0.068768725,0.072760515,0.05325417,0.034013476,-0.03336065,0.058282323,-0.060835198,-0.06037712,-0.09185644,0.006793882,-0.05541114,0.016440593,-0.0002772645,0.078530625,-0.0009991174,0.0546791,-0.0140900025,0.06497662,-0.0013657737,0.09717314,-0.049942005,0.042678375,0.094623014,-0.07168485,0.04702638,-0.057163253,0.0004442208,0.024149435,0.04924796,0.00068270223,-0.0029293983,0.06878125,-0.042608343,0.06254451,-0.013971759,-0.030691532,0.022648903,-0.035453342,0.039486058,0.015724104,-0.09918921,0.07710798,0.11762592,-0.019511718,0.052568153,0.028066402,0.052843425,0.037478946,-0.019613797,0.0563958,-0.06777591,-0.067413375,0.08811849,0.016793376,0.0002978047,-0.008529591,-0.0038096681,-0.019365063,0.021747516,-0.08238324,-0.039279543,0.07958249,0.019897066,0.06969132,0.0012090295,-0.05592767,0.057322502,0.06333451,0.019723328,-3.8608917e-08,0.12993436,-0.060117,0.023019033,-0.09160616,-0.058188897,-0.023911119,-0.007833898,-0.013339656,0.010831552,-0.06993263,0.05206255,-0.011197744,-0.023514159,0.07426047,0.026764475,0.07198551,-0.03892293,0.12626117,-0.031421483,0.08485367,-0.065270424,0.05594182,-0.07176861,0.023288216,-0.008253342,-0.02906602,0.089912005,0.01295845,0.0015518047,-0.014367325,-0.04232709,-0.029147316,-0.06598696,-0.01903965,-0.025306227,0.07549827,-0.06618209,0.053119525,-0.049624827,-0.00090877415,0.050180398,-0.04533295,-0.079989664,-0.045614634,-0.017885268,-0.0420595,0.029583596,0.06555746,-0.07181638,-0.0036786492,0.021427026,0.036120843,-0.050743382,-0.040111005,-0.08261355,-0.010431271,-0.030480307,-0.0970125,-0.004588646,-0.091762766,0.030393288,0.033198003,0.19671953,0.034340438 +3.4.16.6,"A carboxypeptidase with optimum pH 4.5-6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). In peptidase family S10 (carboxypeptidase C family).",384,1.0,0.016108276,-0.04406745,-0.05576363,-0.04264641,0.06576422,0.1454634,-0.017282765,0.08662519,0.0007779876,-0.003541838,0.005778235,-0.02578256,-0.043077417,0.07016925,-0.0627132,-0.023668617,-0.0061155944,0.03633869,-0.008036451,-0.0498052,0.01429931,0.023036754,0.016076243,0.049220145,-0.043009084,-0.086986184,0.005094666,-0.023062449,-0.021187807,-0.05500579,0.021477422,-0.08428071,0.07584251,-0.02192074,0.028197141,-0.006213072,-0.032955207,-0.057370234,0.066882476,-0.014702658,0.033334997,0.03147504,-0.05946781,-0.028790442,0.027113613,0.015708473,0.036238533,0.095397905,0.016934656,-0.0036544395,0.020883596,-0.034830905,-0.033310883,-0.028191427,-0.06295469,0.04481748,-0.010903894,0.064925626,0.05157938,0.031000659,0.040722918,0.022332538,0.06883521,-0.021065785,0.0058323303,-0.0049893092,-0.0016567495,0.03833624,0.067105755,0.021294363,0.0030103861,-0.025422245,0.010484841,0.039582904,0.021753892,0.07427834,-0.063794136,-0.0674328,-0.019028936,-0.035067387,0.027159352,-0.05122474,0.08365489,0.06291889,0.03641557,-0.059945695,0.023983847,0.041296396,0.0076664384,-0.028987406,0.098322436,-0.08066992,0.04374266,0.019134616,-0.06333612,-0.020341136,0.0008463706,-0.06705829,-0.08313328,-0.014782371,0.063035704,-0.0012209371,-0.03975437,-0.076839484,0.0014442441,0.07934949,-0.028811727,-0.016587107,0.015538188,0.016273279,-0.023389231,0.025476063,-0.022443835,-0.060609203,-0.07832721,0.0259677,-0.05984529,-0.06298305,-0.045441985,0.014962268,0.051862318,-0.06901282,0.030964287,0.025624067,-0.009256924,0.016895872,-0.09486592,3.0342951e-33,-0.022681706,0.044208456,0.063168414,0.013907657,0.06035992,-0.041290753,-0.060775306,0.014381037,-0.012342824,-0.021710888,-0.06676697,-0.09728445,-0.020266052,-0.02804817,-0.031127514,0.007342592,-0.15384671,-0.023129005,-0.040979523,0.034381535,-0.030916305,0.05555279,-0.035842035,0.02956619,0.055375647,0.054159615,-0.0251873,-0.0055662883,0.13442789,0.022523196,-0.017025162,-0.04220988,-0.09032577,0.006427411,-0.0139345275,-0.04336627,0.040272363,-0.13240676,0.007530613,0.025115527,0.005384145,-0.016448112,0.01347755,-0.07630428,0.09702511,-0.12087045,-0.019802362,0.060555927,-0.06788933,0.04140815,0.010433116,-0.06239844,0.03548988,0.025167873,-0.07061658,-0.028114215,-0.060976963,-0.029502144,0.0786777,0.052644245,0.09481938,0.009064145,-0.010764596,-0.023036372,-0.05399321,0.031323254,-0.11590548,-0.05183421,-0.0049371254,0.09290949,0.034847204,-0.033075135,0.039248496,0.013414278,0.02475972,-0.06017926,0.011404492,0.08999734,-0.014745046,0.024818532,0.045313977,0.011085094,-0.005211119,-0.005084999,-0.025950914,-0.053511575,-0.0013826994,0.001371893,-0.03039194,0.0176442,0.04751378,-0.028705904,0.020810949,0.063718535,-0.06748756,-2.49761e-33,0.053261206,-0.055816974,0.051455963,0.018456308,0.013786515,0.04081714,0.016999211,-0.02548312,0.06912918,-0.05848391,0.022933211,-0.05679915,0.037643712,-0.059077833,0.015606345,0.023988388,-0.0028176405,0.03092255,-0.036569566,-0.013403039,-0.04896807,-0.020982746,0.02815515,0.10086613,0.023168113,-0.012989898,-0.04642665,0.06305471,0.07865791,0.043410882,-0.015520845,0.041570198,-0.06465918,-0.06414451,-0.08861873,0.0199675,-0.0465106,0.009280385,-0.022664271,0.08200638,-0.01378,0.03283871,-0.0027418886,0.060848705,0.008087565,0.09563582,-0.040082414,0.037580453,0.103436455,-0.06240553,0.057062164,-0.03365301,-0.014099543,0.041730616,0.030039268,0.03087634,0.0020428107,0.03142201,-0.04392969,0.054468803,-0.00481761,-0.041775633,0.009129437,-0.031183133,0.038794097,0.008274049,-0.07844187,0.08581722,0.13221595,-0.044487737,0.05843562,0.03479662,0.055935025,0.052205384,-0.022637349,0.039477628,-0.060209073,-0.056153703,0.08223114,0.008337911,-0.0139742335,-0.0046473453,-0.015890466,-0.02289984,0.017487647,-0.054894567,-0.04527224,0.08709608,0.022447161,0.046015058,-0.030412897,-0.04067304,0.05612862,0.060971253,0.019772602,-3.6641346e-08,0.13576518,-0.067097895,0.02980813,-0.09977187,-0.0528562,-0.017501911,-0.0027374818,-0.016344463,-0.024534173,-0.07306941,0.057737842,0.003860806,-0.041790787,0.05198831,0.026923783,0.054939937,-0.022540176,0.14090323,-0.04261274,0.07344873,-0.080312304,0.06856776,-0.071968846,0.00090113666,-0.0029230004,-0.030496454,0.081896484,0.015022191,0.00081975263,0.012586762,-0.022539163,-0.02190898,-0.04095015,-0.018697396,-0.03459891,0.07439469,-0.061317448,0.06856907,-0.06459483,0.0018311457,0.052135967,-0.04603648,-0.05695895,-0.038781725,-0.0110657215,-0.06379447,0.050330833,0.05553946,-0.05545274,0.034157224,0.016216254,0.031643573,-0.072594546,-0.029831205,-0.067482404,-0.011942832,-0.025174918,-0.087094195,-0.0060008853,-0.104106516,0.010683952,0.024995422,0.20959409,0.03640378 +3.4.17.1,"A zinc enzyme formed from procarboxypeptidase A. Isolated from cattle, pig and dogfish pancreas, and other sources including mast cells [3] and skeletal muscle [4]. Type example of peptidase family M14.",384,1.0,-0.03650868,-0.0037291273,-0.113646775,-0.01521729,0.08084937,0.0629852,0.0026836677,0.06364015,-0.033709902,0.034504246,0.0441969,-0.046972744,-0.00039365308,0.019909803,-0.063643396,0.005832504,-0.025488282,-0.040659577,0.019188179,-0.045721456,0.05489426,0.04395958,0.044014227,0.018868858,-0.008319623,-0.07988505,0.071295284,-0.020911887,-0.009961845,-0.010409089,-0.05998682,-0.0889061,0.065182045,-0.03467269,0.081688024,0.006015542,-0.008878624,0.027859775,0.034974467,0.02051419,0.07876483,0.076598294,-0.014066005,-0.08135075,0.01620778,0.036902826,0.052039135,0.008181819,0.007439833,-0.01683026,-0.058396287,-0.101648785,0.020698238,-0.003985349,-0.013437819,-0.023606295,-0.069339536,-0.025337974,0.011446015,0.031484254,0.052038953,0.016627517,-0.011165877,-0.04303408,0.04668387,-0.008155036,-0.00731639,0.022902623,-0.027790625,-0.066659324,-0.02983775,-0.023433516,-0.056201637,0.072178006,-0.053362522,0.05403149,0.024943197,-0.10526842,-0.0043947697,-0.02908777,-0.04695021,0.009730116,0.06239246,0.045106538,0.025048211,0.06110104,0.0038190961,0.09610464,-0.038576733,-0.04647872,0.010591828,-0.06143959,0.0045157834,0.008912397,-0.05381769,0.015546453,-0.04140457,-0.03895694,0.0549649,0.034307953,0.05718493,0.011206315,0.06270391,-0.15502791,-0.036238838,0.13137677,-0.009627274,0.06740719,0.046392348,0.10263898,-0.027584111,-0.004604749,-0.063160874,-0.032734755,-0.002564384,0.054958478,-0.047791626,-0.037176993,-0.055037882,-0.0012869602,0.054031193,0.029174395,0.06224546,0.021311032,-0.003899993,0.10261924,-0.079463914,1.4009385e-33,0.0051364186,0.0018291916,0.048302997,0.01900417,0.022804795,0.05344598,0.0035988465,0.02334527,0.026822906,-0.048391428,-0.10248924,-0.0741642,0.0044363756,-0.020379316,-0.05791385,-0.034995086,-0.036074236,-0.02687761,0.048182193,0.04155055,-0.0323783,0.108389676,-0.03901196,-0.032224365,0.06214812,0.0026252335,0.029540192,-0.049420398,0.038965907,-0.011921564,0.0010079354,-0.08264817,-0.076862566,-0.016634213,0.119565,-0.0443834,0.05318502,-0.07808641,-0.014669532,0.0049335253,0.038507566,-0.07130977,-0.008033842,-0.006191147,0.10192749,-0.083089784,-0.06832781,0.03857527,0.021086887,-0.026785893,0.023156196,0.03272622,0.08659461,-0.033220403,-0.15214974,0.03542429,-0.018744078,0.056101277,0.11040053,0.0686817,0.008630682,0.05337447,-0.04520464,0.039241895,0.012954106,0.026488194,-0.15433335,-0.035827547,-0.061767012,0.1006028,-0.01494701,-0.061926123,0.019342072,-0.018843956,0.019260682,-0.08249168,-0.059706684,0.028020713,-0.0049006804,-0.045077417,-0.033895504,0.034477253,-0.019072156,0.045312062,-0.07197811,-0.02356318,-0.024600405,-0.016647233,-0.030888889,0.0023683126,-0.019999593,0.0040905364,-0.047942515,0.0072851377,-0.008817352,-2.3409814e-33,0.029508105,0.02663377,0.047333825,-0.06657554,-0.011028826,0.011449344,0.037875205,-0.013307453,-0.008177272,-0.043973245,0.040641114,-0.05199254,0.06430306,-0.04544159,0.05151444,0.039136376,-0.05236106,0.103638545,0.0233437,-0.03589957,-0.038071796,0.05774793,0.04456591,0.032214254,0.045850143,0.0052377046,-0.03422926,0.13012138,0.070993826,0.023318928,-0.040803198,0.06301387,0.009999541,-0.077461615,-0.13373576,0.017767154,-0.05767847,-0.014346212,0.02169827,0.03074672,-0.047936752,0.009960546,-0.0027035912,0.09710355,0.031055588,0.062914774,-0.07604359,0.009365368,0.031877622,-0.013306214,-0.016819837,0.013122141,0.0082888305,-0.07429954,0.07930809,0.0030276973,-0.008936562,0.0070493333,0.013095474,-0.028489389,0.017399255,-0.026117127,0.03825554,0.054572035,0.116835736,-0.00619038,-0.026694734,0.00041428275,0.03093337,0.03731559,0.08092783,0.061221242,-0.016799372,0.01672162,-0.023336526,0.07348807,-0.035015967,-0.03141849,0.0003699336,0.0008648549,0.033234324,-0.060230467,0.051695537,0.010098798,-0.00032912393,-0.086440966,0.00655047,0.08336227,0.02232147,0.040750835,-0.041342586,-0.035594396,-0.00876175,0.086035945,-0.0068545816,-3.10366e-08,0.06927588,-0.037483502,0.035637807,-0.05246401,-0.056153104,-0.058980096,-0.013282093,-0.08667643,0.026711972,-0.067007154,0.00946452,0.0064656967,-0.01754407,0.061178755,0.0490677,0.05467419,-0.012893144,0.05210759,-0.028607821,0.07489322,-0.05513032,0.033376124,-0.10252721,0.044440288,-0.03808841,-0.07158112,0.0026792744,0.0976873,-0.02286658,0.014149529,-0.053393114,0.019946823,-0.0023051435,-0.05759668,-0.034276288,0.067162625,-0.07643654,0.022180822,-0.055960007,-0.023026198,0.00044686368,-0.061952554,-0.020922052,-0.05667299,-0.007736481,-0.09224826,-0.0048717866,0.018789025,0.036066636,-0.001140194,-0.034378238,-0.0017617455,-0.022100767,-0.07405436,-0.013358195,0.029450027,-0.04423887,-0.08407709,-0.00042204966,-0.07672408,0.019054152,0.026174694,0.19136128,0.05597842 +3.4.17.2,"A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family).",384,1.0000001,-0.040726215,0.013247238,-0.11042382,0.029033681,0.095584676,0.06881344,0.025372814,0.06270355,-0.04457674,-0.0005360388,0.028379295,-0.068615556,-0.019355996,0.017479816,-0.06323058,0.008934808,-0.023711722,-0.030951925,0.02711437,-0.01954486,0.022013018,0.04468552,0.04539259,-0.0022695437,-0.0004595285,-0.08118421,0.058692735,-0.01162482,-0.024326304,-0.0033008368,-0.061583403,-0.10406235,0.06854098,-0.015181339,0.08017621,-0.023187483,-0.00422998,0.022059606,0.03493241,0.019111572,0.06804996,0.06150565,-0.041454725,-0.06198788,0.020191586,0.04303334,0.063635044,-0.004072004,-0.0046182764,0.0020846322,-0.057083674,-0.09675097,0.047047522,0.017478285,-0.03429239,-0.0016199334,-0.07130661,-0.018453682,0.0041545904,0.029692203,0.022951456,0.017777821,0.0038801464,-0.046190806,0.06626866,0.0065903333,0.0063804095,0.02140814,-0.016363937,-0.07712204,-0.002301184,-0.017503044,-0.04089602,0.04530623,-0.06067873,0.06344179,0.000669582,-0.09188853,0.023355892,-0.034598596,-0.005235415,0.026894018,0.055910416,0.040200338,0.023081185,0.03027035,0.0007760045,0.09719516,-0.06629634,-0.043894295,0.021297999,-0.049951617,-0.016497927,0.03145197,-0.05613835,0.0014087135,-0.031987954,-0.036269497,0.044191185,0.028896641,0.023270708,0.004577653,0.058391735,-0.15020663,-0.01652877,0.10722981,-0.022745682,0.07422799,0.052767683,0.08630084,-0.026109867,-0.0023470821,-0.05441684,-0.023730144,0.01104681,0.06314796,-0.056186005,-0.036389265,-0.07362557,0.002197043,0.045940842,0.018811401,0.0378551,0.022033138,0.020688856,0.09539369,-0.063127995,2.8470177e-33,0.0075510857,0.021716675,0.028140545,0.025622629,0.035289098,0.060690973,0.0035908688,0.048764776,0.009561644,-0.015820682,-0.11732266,-0.09152393,0.015907876,-0.02420345,-0.050333794,-0.050235078,-0.039598223,-0.057202823,0.07533117,0.027369715,-0.021873599,0.094516516,-0.055944383,-0.0073160715,0.024074454,0.01566116,0.013596197,-0.03434997,0.07407181,-0.007738212,0.02127001,-0.08805162,-0.046656154,-0.024252981,0.11856274,-0.029920537,0.054289803,-0.08942271,-0.018048309,0.020515595,0.049665697,-0.09716585,-0.0071210433,0.0048211664,0.093438305,-0.077920556,-0.09067313,0.030903598,0.010984134,-0.0171228,0.03616929,0.038231723,0.071601175,-0.0273885,-0.13725974,0.031735443,-0.056574196,0.027519658,0.08444318,0.08492172,0.033153232,0.06317445,-0.05793942,0.020164227,0.0026789056,0.010468878,-0.13839222,-0.039323334,-0.10519283,0.07072463,-0.008907241,-0.06960858,0.050735638,-0.04246296,0.0070900694,-0.0592174,-0.06659033,0.034051172,0.00040705514,-0.08544147,-0.06182058,0.042600803,0.008450103,0.046608903,-0.04999621,-0.032827616,-0.017965434,-0.008601486,-0.034129873,-0.0066835,-0.020188278,0.005138324,-0.048066214,-0.0047458927,-0.012302644,-3.127064e-33,0.02260702,0.0014986912,0.035189755,-0.04827259,-0.0057242396,-0.0051815254,0.02221405,-0.021503069,0.022642868,-0.015505779,0.04517989,-0.04922343,0.08055748,-0.063098244,0.036904417,0.046065018,-0.070354395,0.09931883,0.03835989,-0.062231313,-0.031210301,0.04085175,0.023118949,0.04615309,0.054045253,0.006083295,-0.0051105376,0.107352085,0.080185555,0.03837581,-0.025254529,0.05749888,0.008356553,-0.099196024,-0.127296,0.021932311,-0.064324,-0.053531166,0.012359087,0.05210105,-0.064153105,-0.029414466,-0.037327126,0.08165337,0.047829635,0.069356576,-0.07252544,0.012414227,0.040134866,-0.02123506,0.0033535378,0.034208998,0.0057308967,-0.07055946,0.06671461,0.0363578,-0.00686177,-0.0014354086,0.031467076,-0.014709877,0.047225837,-0.008628771,0.032506295,0.052553825,0.105235755,-0.016571898,-0.0045226514,0.009596712,0.044050597,0.016255911,0.08790989,0.08640037,-0.02862345,0.04630803,-0.019637965,0.06297845,-0.029615398,-0.016489927,0.014283618,-0.0018177973,0.025608141,-0.07457014,0.07424365,0.018974047,-0.013231121,-0.06770616,-0.016514653,0.09203227,0.013350507,0.015792172,-0.076103106,-0.034349386,-0.0038421962,0.055998407,-0.029833646,-3.445052e-08,0.07999882,-0.032220885,0.018905943,-0.089821294,-0.034050517,-0.040253837,0.013112252,-0.06370579,0.022346254,-0.06382165,-0.012034099,0.010486537,-0.046979055,0.04220543,0.040475897,0.047172043,-0.007684958,0.064146444,-0.037254207,0.07517732,-0.047691114,0.049313966,-0.08264308,0.018911188,-0.023109805,-0.08305461,0.027663644,0.109053805,-0.020202802,0.026711095,-0.060184192,0.004217738,0.0030662892,-0.06623563,-0.011117685,0.071949445,-0.077316284,0.009426669,-0.05298675,-0.0055056005,-0.010230018,-0.07224228,0.0067398082,-0.060308143,-0.007346624,-0.10482753,0.0146558145,0.03522276,0.051344518,-0.012169615,-0.03900872,-0.012732954,-0.053512577,-0.03817694,-0.0006614984,0.016332138,-0.047710527,-0.07840341,-0.002078829,-0.05689424,-0.02000016,0.058641717,0.20212997,0.047906943 +3.4.17.3,A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family).,384,1.0,-0.06775017,0.04750656,-0.09278844,0.023245368,0.11209626,0.06832329,-0.011190479,0.046443585,4.979663e-05,-0.0011449825,-0.014828361,0.004762982,0.021275833,0.040023264,-0.07765253,-0.0007908064,-0.021869658,0.045119252,-0.04875983,-0.019420592,-0.038665213,0.05958957,0.025761686,0.023157476,0.044418868,-0.06579645,0.033660475,-0.04330371,-0.03536521,0.024304613,-0.01054756,-0.045485247,-0.0066913567,0.007410577,0.0754124,0.019537346,-0.020806778,0.011279052,-0.028542995,0.030756889,0.07596499,0.049197022,-0.06220228,-0.06902583,0.04070853,0.011614011,-0.0070683686,-0.029451434,0.051033076,0.052236278,-0.10491189,-0.010017685,0.021984482,0.03583952,0.0047266814,-0.012602336,-0.10284295,-0.039605085,0.016459404,-0.0036519133,0.013412706,-0.037544247,0.0052480116,-0.010264182,0.012464734,-0.033372454,0.0034558743,0.030081185,0.0050934786,-0.0986345,0.0043518078,-0.020846738,-0.03697294,0.038047865,-0.04517679,0.03181578,-0.030902509,-0.13870658,-0.03007641,0.0074383044,0.029364483,-0.009395724,0.054887578,0.1228664,0.07526268,0.088360295,-0.042722415,0.07025612,-0.11503264,-0.00096079905,0.037250068,-0.040441826,0.055076085,0.032134634,-0.08758407,-0.028391676,-0.0007576163,0.023223633,0.03153377,0.039312333,0.029088669,0.046615764,0.008663374,-0.08715643,-0.00852747,0.060494117,0.016495219,0.05845235,0.034257114,0.058545765,0.003861242,-0.03819133,0.004291066,-0.05968704,0.026887503,0.09855846,-0.017384833,0.0021639648,-0.100051664,0.041155234,0.055887695,-0.0036749511,0.005655194,0.023768546,0.016944928,0.08991285,-0.049421653,2.2502813e-33,0.013952748,0.0423988,0.07160326,0.08402682,-0.013788148,0.06756681,-0.015355245,0.024577234,0.08649619,-0.04487046,-0.1038555,-0.0044415034,-0.012542507,-0.014585159,-0.07530068,-0.06877069,-0.07834966,-0.11302486,0.032142892,0.03993918,0.03489327,0.05395585,-0.077346906,0.0009529574,-0.015015597,0.03718284,-0.0075918287,0.035394832,-0.006251243,-0.0010956306,0.008737342,-0.011545972,-0.0920933,-0.034511793,0.06911905,-0.088522874,0.046578314,-0.037662897,-0.046728563,0.003874943,-0.058418967,-0.006013403,-0.09183143,-0.029796163,0.09647485,-0.09468285,-0.0688856,0.069025055,0.026163427,-0.024237463,0.074744076,0.014445136,0.08899876,-0.05720544,-0.043779325,0.035951834,-0.020187588,0.0039581563,0.0508006,0.09309039,0.07654405,0.03989883,0.0024523702,0.073514566,-0.04001266,0.040211033,-0.05963547,-0.07650144,-0.042636264,0.034471504,0.03211936,-0.008149282,0.037900735,0.043397747,0.06245292,-0.09079886,-0.029831752,0.06726824,-0.009205118,-0.11538902,0.023513805,-0.029239532,0.024394602,0.1278302,-0.026450856,-0.102468,-0.004103097,-0.021123728,-0.044854272,-0.026375838,0.0057125553,-0.008108446,-0.060400978,-0.02470592,-0.04026011,-3.586475e-33,0.08881854,-0.007751487,0.004230824,-0.085175104,0.011650788,0.070405886,0.028303321,-0.02445632,0.06427196,-0.031100037,0.10765508,-0.00023577623,0.029694643,-0.027229859,0.01954151,0.036374517,-0.04841216,0.028943324,-0.007678695,-0.009713193,-0.07353715,0.0028328707,0.04210758,0.03882684,0.07209127,0.011408659,-0.042792324,0.04875127,0.044717666,0.039550718,-0.054754954,0.056882802,-0.04740529,-0.06856698,-0.07965244,0.045946606,-0.007666369,-0.029171074,-0.061072763,-0.02882242,-0.046227068,-0.0069559403,-0.0056431736,0.10349517,0.05894277,0.063511476,-0.062257785,0.00056907313,-0.017925244,-0.053887323,0.007124882,0.037782572,0.001002701,0.0038629333,0.026752142,0.06580884,0.021921456,0.011025253,0.014598676,0.037557878,0.04208364,-0.0036759623,0.00019993763,0.07432545,0.011780133,-0.0006927044,0.010161581,0.06468743,0.0664466,-0.022302343,0.11388058,0.022998843,0.020918598,0.019024875,-0.030037416,0.06501458,-0.07055699,-0.05004839,-0.01421844,-0.0021433781,-0.02511563,-0.0003392665,-0.038110137,-0.0048978995,-0.06545806,-0.08456489,-0.0006290266,0.0075979363,-0.031698782,-0.006237331,-0.059579067,-0.01181423,-0.05044433,0.037919227,-0.079351485,-3.0114567e-08,0.112164885,-0.061982166,0.042226184,-0.09990071,-0.09525904,-0.051799398,0.0055957194,0.0155154895,0.0020628145,-0.021008847,0.052870005,0.071452945,-0.009703473,0.010742159,0.017993888,0.041630886,-0.020920204,0.015123227,-0.043887716,0.06981082,-0.012617377,0.09931211,-0.05273011,0.025596196,-0.017875817,-0.047050036,0.0023954082,0.0422635,0.054906767,0.009606714,-9.250186e-05,-0.000447763,0.052161817,-0.078078516,-0.08408779,0.021471482,-0.043482564,-0.023502579,-0.03665143,-0.05451288,-0.045974553,-0.096046165,-0.02084985,-0.057777576,0.000731209,-0.08340354,0.029293355,-0.002158026,0.04663777,-0.0076259724,-0.0012113161,-0.00084106025,-0.07641279,-0.082939535,-0.044713527,0.034940224,-0.032030962,-0.07485107,0.018291265,-0.14105713,-0.05546899,0.048054285,0.15731497,0.048600975 +3.4.17.4,From yeast. In peptidase family M20 (glutamate carboxypeptidase family).,384,0.99999994,-0.03516783,-0.03804328,-0.08828844,-0.03507875,0.021645747,0.047066204,-0.00042223785,0.07980942,0.00861559,-0.0010972129,0.08691421,-0.046707865,-0.02586085,0.017841134,-0.076899424,-0.0035351801,-0.016389735,-0.0382067,-0.035701282,-0.059860367,0.11381917,0.10165018,0.02248184,-0.019119825,0.0029232902,0.0040074433,0.051144198,-0.012238296,0.055005938,-0.09238557,0.006392094,0.0009401308,0.11554814,-0.015347898,0.054726113,-0.003987813,-0.021443326,-0.07796666,0.13836789,-0.025309999,0.01358762,0.043930504,0.002670143,-0.053795937,0.035115782,0.08508627,0.06493614,0.046956033,0.049065765,-0.012325962,0.0134855835,-0.09255582,-0.0061937,-0.016559966,0.008464911,0.027582487,-0.065749116,-0.008326325,0.015408974,0.074779235,-0.0088698035,0.023370583,-0.007014844,0.00079547346,0.0011874853,-0.03678783,0.08275397,0.030746795,0.04835866,-0.05497146,-0.01662301,-0.04640299,-0.019844959,0.07876894,-0.020785494,0.06220628,0.07500199,-0.06567275,-0.027884737,-0.03649488,-0.003617692,0.016683992,0.1114859,0.034167364,0.032923345,-0.019268947,0.029583273,0.08238086,0.0048494856,-0.010491325,0.010553137,-0.06934176,0.010078029,0.061605155,-0.10060459,0.016229514,0.0040498185,-0.005341486,0.030335164,-0.026016891,0.0144540705,0.037695784,0.054574262,-0.038246036,-0.038612653,0.085552946,-0.006759363,0.06034425,0.06174908,0.03744848,-0.023528952,0.027680444,-0.015288615,-0.07069426,-0.060550828,-0.02347685,-0.0041433377,-0.0053323037,-0.016915614,0.015316507,-0.020759182,-0.013704484,-0.0029807412,-0.0034228095,-0.08999004,0.033726662,-0.07819526,2.816564e-33,-0.0008921196,0.0033004077,0.02692009,0.013713298,0.0660501,-0.030995354,-0.056752536,-0.03701159,0.025362242,-0.05628667,-0.11411325,-0.09527717,-0.06052952,0.0008268583,-0.0660442,0.039179746,-0.103862576,-0.029853625,0.0020611812,0.036021806,-0.069077924,0.10056517,-0.021484725,-0.056734484,0.059388794,0.07072638,0.048593402,-0.035876203,0.07227217,-0.0064516575,0.009679325,-0.047520924,-0.09800296,-0.01702986,0.004000056,-0.009728902,0.05629625,-0.1242153,0.0074804462,0.040497344,0.022162303,0.0057056337,0.0016031027,-0.027428424,0.029821442,-0.05158591,-0.045642026,0.027949722,0.015158172,0.084211126,-0.012228655,-0.039879084,0.06312042,0.040450063,-0.0684461,0.03673806,-0.048482515,0.00797623,0.10500737,0.055294048,0.025144782,0.10453082,-0.010414017,0.034039967,0.010111052,0.028717797,-0.12950112,-0.079762585,0.0028252914,0.0766084,-0.014884835,-0.07791524,0.032770958,-0.019384027,0.03972601,-0.07691184,-0.042368975,0.018291544,-0.018638074,0.028711144,-0.009131669,0.008206207,-0.0029862938,-0.023041429,-0.08895146,-0.0033035285,0.030939685,-0.03194598,-0.044906735,0.010449528,-0.011713403,-0.0146903945,0.025282782,0.046383396,-0.07412461,-3.144656e-33,0.12533908,-0.022726953,0.074558325,-0.010048618,-0.03868012,0.042454522,0.023566347,-0.037926115,-0.03235917,-6.6712346e-05,0.0072227293,-0.026550371,0.052656878,-0.05949201,0.02286854,-0.011921528,0.0038296452,0.089866854,-0.050732154,-0.0028738196,-0.0020151748,0.064715505,-0.020327356,0.03385337,0.0554169,-0.008318603,0.028173385,0.09370144,-0.0043645496,-0.021627272,-0.005783394,0.004623132,-0.03879358,-0.051727943,-0.06953947,0.04077311,-0.024082262,-0.0030404837,-0.057774156,0.013828466,-0.022640731,0.13074522,-0.016525311,0.05203657,-0.027207099,0.08094294,-0.017825872,0.0069287578,0.04830802,-0.072000094,0.050743684,-0.021688085,-0.004155699,-0.019855764,0.048479136,-0.022844074,0.043696914,0.023130916,-0.018715588,0.005298938,-0.0071839774,-0.059495956,0.0051705446,0.0057257693,0.08040353,0.053027574,-0.04558363,-0.0015935045,0.08226096,0.005642825,0.0669127,0.017670598,0.047375042,0.05907228,-0.03169636,0.03870928,-0.09517705,-0.11245639,0.016377335,-0.10028248,0.010271191,-0.07990732,0.00894468,0.03936243,-0.02062532,-0.123562254,0.005511995,0.082527295,0.06250292,0.04925069,-0.02716889,-0.023529813,-0.015147035,0.080201745,0.03179725,-2.5373264e-08,0.08497876,-0.07726,0.030343538,-0.055169493,0.0017998209,-0.0010328798,-0.023240194,0.003051161,0.036833204,-0.03486712,0.001587574,0.037187982,-0.07773601,0.06906779,0.018359262,0.06234329,-0.038991388,0.08634843,-0.013374221,0.045876153,-0.073722154,0.020190198,-0.04855543,0.03445172,0.026258437,-0.06005725,0.05069668,0.12075092,0.008012887,-0.05867395,-0.03122328,0.030059107,-0.0038002175,-0.07285245,-0.026260803,0.045650907,-0.040590078,0.026834557,-0.058607396,-0.04282157,0.034082785,-0.061377224,-0.019199466,-0.043908846,-0.03937664,-0.022873284,-0.0078122094,0.05173514,-0.066486396,-0.025608838,0.049346335,0.018168814,-0.044927318,-0.016910678,-0.16763034,-0.008026381,-0.06039214,-0.09665547,0.021868024,-0.100370236,0.0021804182,0.03291187,0.16613889,-0.0066105076 +3.4.17.6,From soil bacteria. The enzyme from Corynebacterium equi also hydrolyses N-benzoylglycine and N-benzoyl-L-aminobutyric acid.,384,1.0,-0.08684704,-0.062977694,-0.03038375,-0.026692469,0.04193758,0.07903685,-0.04592857,0.04798251,0.06632589,-0.0017178861,0.022675432,-0.052242752,-0.029600658,0.029347762,-0.098167665,0.023354156,-0.057681076,0.031955067,-0.06048754,-0.086045206,0.045709662,0.09717116,-0.038344096,-0.002012153,0.012825306,-0.013033826,0.055260967,0.01980136,0.041727535,-0.08546195,0.06645716,-0.061009087,0.013323046,-0.05445415,0.06613077,0.07652213,-0.07757771,-0.12512565,0.112595536,0.01651473,-0.015506215,0.012358248,0.016628182,-0.035703562,-0.09433662,0.026026238,0.040458407,0.012483176,0.09066922,-0.019764114,0.04238678,-0.036605388,-0.09248922,0.026777716,-0.008203762,0.0052346503,-0.051856216,-0.03878235,-0.0049127475,0.009613794,0.028987775,0.026962148,0.08655168,0.022108076,-0.042171523,0.037086643,-0.0028123744,-0.051593307,0.047181554,-0.08796555,-0.07427032,-0.038405746,0.019441806,0.051567737,-0.05939032,0.014717099,-0.060486283,0.0038152619,0.042320102,-0.073853105,-0.051098146,0.013635992,-0.036208455,0.027801845,-0.021530597,0.0082406225,-0.024104858,0.027905768,0.1364217,0.0068588117,0.04150211,-0.023411963,0.015695289,-0.037937343,-0.040690567,-0.004766814,0.020382177,-0.014848419,-0.020012608,-0.0091846585,-0.038330205,0.10948222,-0.0055882926,-0.087002,-0.038649365,0.0252977,0.024666771,0.027334081,0.067774005,0.05713547,-0.06256642,0.010119609,0.03094217,-0.06352705,-0.014662143,-0.036513235,0.082497835,-0.034541216,-0.063272096,0.02862323,0.0071558566,-0.09818223,0.02808412,0.020641359,0.005919848,0.028753689,-0.049319904,1.9995811e-33,0.034726262,-0.0033653216,0.05801033,0.02329608,0.047844306,-0.024940444,-0.051242664,0.022421159,0.057654332,-0.08019838,-0.12196664,0.013946838,0.018539287,-0.009875806,-0.01749999,0.07641449,-0.038663123,-0.030548967,0.018181494,0.08695832,0.02004801,-0.024712024,-0.015552742,-0.0037964038,-0.022485161,-0.019740807,0.0076679233,0.043478336,0.07509882,-0.024198605,0.0052189003,-0.117195256,-0.13504161,-0.0058425493,0.043572158,-0.011234563,0.00030242535,-0.023632523,0.05772466,0.050908044,0.083640784,-0.011965698,0.041770004,-0.009676241,0.050204493,0.005982734,-0.039419167,0.06317201,0.030585103,-0.040115707,0.0835334,-0.042870864,0.082587786,-0.03936773,-0.037560638,0.014697157,-0.0059824465,0.023798833,0.028792078,0.09729133,-0.01460226,0.08628043,0.0012116773,0.00039814992,0.049324177,-0.0023867977,-0.04775899,0.09450075,-0.011860085,0.011064926,-0.07247263,-0.051359016,0.051822748,-0.0045137815,-0.07663885,-0.08924837,-0.10311421,-0.06583019,0.043398865,0.033321224,-0.011000965,-0.031331457,-0.009122804,-0.062326342,-0.056351934,0.0013780365,-0.027960096,-0.032610796,0.020803614,0.00892732,0.06012842,-0.059429422,-0.040743526,0.007549034,-0.025626658,-3.8006363e-33,0.12761211,-0.053028766,0.00087744126,0.0033868363,0.039432183,-0.014239099,0.05491307,0.03769553,0.036843657,0.0207418,0.06041336,0.010615361,0.03363081,-0.017317075,0.028694907,0.047143612,0.04515365,0.103274845,-0.020737063,-0.09153373,-0.08368169,-0.008210315,-0.016326755,-0.08786358,0.018813053,0.06619646,-0.07827399,0.08484165,-0.011651405,0.06205732,0.015407368,0.018020825,-0.018525483,-0.03238082,-0.084765516,0.044483468,-0.013345678,-0.07509834,0.043687146,-0.04697987,0.052890655,-0.015979204,0.01682861,0.07912863,-0.022950398,0.05415578,-0.06397626,-0.04233331,-0.01467787,-0.01071153,0.044487186,0.016617892,-0.05425584,0.05224547,-0.020978153,0.07591534,0.01355742,-0.01034425,-0.019980334,0.011530049,-0.011139467,-0.035010833,-0.008468476,0.008469656,-0.03403463,0.040128578,-0.007955914,0.0726686,0.048965983,0.00081088406,0.021070642,0.00968052,0.08600035,0.021455768,-0.039410725,0.10131437,0.02150101,-0.049340487,-0.04388341,-0.11034514,-0.0013124614,-0.076092824,-0.055173647,0.007835917,-0.0035674882,-0.07476998,0.005900975,0.052450955,0.04335477,0.03817029,-0.027394798,-0.04804223,-0.017967606,0.101561606,0.08594496,-2.8667603e-08,-0.022896834,-0.01801059,0.06212651,-0.026784498,0.068253234,0.036572304,0.026885495,0.073196605,0.067594185,-0.08215097,-0.05546756,-0.009175277,-0.06293318,0.054594122,0.047722355,0.055968184,-0.08632743,0.04535988,-0.017691178,0.018198954,-0.073036924,-0.013730629,-0.037453264,0.023157073,-0.011903404,-0.031783454,0.034491602,0.0038311547,-0.05658727,0.005654128,-0.016545266,-0.018105501,-0.046100404,-0.07465679,-0.019744737,0.061518382,0.014471245,-0.04689549,-0.019660262,0.013376415,-0.0039056197,-0.011380812,-0.110647455,-0.025293162,0.0852737,0.038889565,-0.06959566,0.10761338,-0.02426368,-0.014551078,0.035433646,-0.016506858,-0.039643414,-0.04891932,-0.0765193,-0.009258901,-0.047957487,-0.06819594,0.02696994,-0.0028886013,-0.04369786,0.029862376,0.2127355,0.0037893644 +3.4.17.8,"A bacterial enzyme that requires a divalent cation for activity. Does not cleave the C-terminal D-alanine from the product of the above reaction, UDP-N-acetyl-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine. Competitively inhibited by penicillins and cephalosporins.",384,1.0,-0.032342765,-0.09412431,-0.01643875,-0.06278827,0.015510415,0.02513075,-0.003888334,0.067131445,0.06750505,0.042557817,-0.019936776,-0.05130874,0.017085256,0.12845798,-0.045073085,0.0076873414,-0.022374744,0.017541032,-0.007649925,1.9364008e-05,5.0691207e-05,0.07455269,-0.0014960235,-0.034112275,0.027444297,0.054617096,0.09281808,0.06464368,0.036857877,-0.047359288,0.021251306,-0.07473388,0.07751287,-0.028936801,0.09583359,0.055091903,-0.02666766,0.0050069573,0.10020528,0.0050289794,-0.029752081,0.038341515,0.020971261,-0.03031766,-0.020471962,-0.0027703696,-0.06158477,0.08035169,0.008181808,-0.04491339,0.012654934,-0.08868658,0.0042908094,0.061531607,0.05153516,0.017703412,-0.10655767,-0.06282427,-0.037782572,-0.068371974,0.041638866,0.054266006,0.07134928,0.0029648305,-0.014507329,-0.044890773,-0.030367827,-0.043109316,0.0632203,-0.00014625833,-0.07529754,-0.080671206,-0.045571752,0.026900036,0.03965705,-0.036068335,0.0023089373,-0.08086453,0.060970586,-0.10947068,0.0418818,-0.036572836,-0.006198307,0.09252553,0.046350975,-0.03670445,0.043787,-0.018358754,0.09817179,-0.01245725,-0.035571765,-0.0051893573,0.025731334,-0.07579664,-0.10333283,-0.02878275,-0.032392763,-0.02106442,-0.05521392,0.041604847,-0.03247037,0.097325176,-0.07471696,-0.045786425,-0.05586118,-0.057910122,-0.022450808,0.014508612,0.0027105415,-0.04524491,0.060606904,0.0037179173,-0.0057335394,0.054319423,-0.0032488818,0.039503757,0.085652195,-0.039211582,-0.033057258,-0.027832668,0.04363695,-0.014759283,0.023590716,0.013768468,-0.049732424,0.04877818,0.010995441,1.3166411e-33,0.015236433,-0.044253908,-0.019670328,-0.023355,0.047456548,-0.056526326,-0.08931188,0.048195537,0.00894697,-0.035261855,-0.084613085,-0.049209993,0.030903738,0.046619035,0.06655074,0.06552826,0.029207801,0.027801188,0.06649487,0.0066957586,0.03882073,0.025686258,0.033406485,0.040481918,0.065681286,-0.01308469,0.015676582,0.07719942,0.13480072,-0.005490078,-0.048871793,-0.05576884,-0.04205734,-0.016235635,-0.023259362,0.0003217109,-0.10592776,-0.029083971,0.041226037,0.045021914,-0.051156346,0.04137653,-0.012513134,-0.017117195,0.037440583,-0.00484088,-0.014790155,0.077492006,-0.041140188,0.07014647,0.11017988,-0.042677913,0.067949064,-0.06713152,-0.0048259045,-0.019462723,-0.039939884,-0.003689976,0.024040056,0.07535254,0.062197328,0.006476367,-0.045592915,0.040063314,0.010562752,-0.02452639,-0.0054963063,-0.06661809,-0.012054685,0.0312087,-0.0818769,-0.023280704,0.027339006,0.04527425,-0.03296602,-0.07665475,-0.036398362,-0.0137101235,0.08478245,-0.059949767,-0.050174493,-0.033977836,-0.017065581,-0.04206283,-0.02095697,-0.016014392,-0.06652344,-0.03281448,-0.031231245,-0.04115493,-0.037956048,-0.007877369,-0.09531108,0.14203057,0.04577544,-2.8074131e-33,0.041595813,-0.103257015,-0.009404553,0.01005427,-0.062202178,0.08573842,-0.009324071,-0.037645202,0.05343367,-0.051016744,0.0433388,-0.006399845,-0.0058005024,0.0142480945,0.022801531,-0.03580235,-0.0058659324,0.08090069,-0.057141516,-0.019350588,0.027893092,0.0012708334,-0.011018098,-0.022984188,0.045668453,0.045855295,-0.026281137,0.0054254965,-0.01536318,0.10693513,0.056619845,0.044301126,-0.035275158,-0.10920175,-0.0961416,0.13212864,0.0516457,-0.007424571,-0.07597553,0.02396798,-0.012137129,0.06330345,0.0017230149,0.088775,-0.023053009,0.037502248,-0.04065049,-0.03996171,-0.005392936,-0.0337328,0.016491683,-0.048083317,0.06842611,-0.016414097,-0.013786629,0.05473844,0.03402316,0.0049141627,-0.0094362395,-0.010541631,-0.029402161,-0.07599691,-0.013185388,0.0061370353,0.067948595,0.04511695,-0.02316392,0.08499986,0.10424826,-0.05864912,0.085058555,0.00028636798,-0.007260128,0.0047220467,-0.061275832,0.02917899,-0.020205753,-0.062246643,0.07792645,-0.014603878,-0.02905386,-0.021169774,-0.011059748,-0.02184832,-0.11399758,-0.059537895,0.033247896,0.05162652,-0.00091498444,0.093517706,-0.0044137533,0.010113249,-0.018181741,0.001894709,0.08171735,-4.255794e-08,0.078222506,-0.061736673,-0.0064102747,-0.022429427,0.015893593,0.003867103,-0.02542855,0.021275707,0.0500205,0.011233307,-0.019959627,0.06488241,-0.013433364,0.023336878,-0.0054856953,0.06784942,-0.07140381,0.007224075,-0.062143363,-0.027440118,-0.06070008,0.018046267,-0.09032163,-0.009118126,0.018563617,-0.1254381,0.03517441,0.07711283,-0.07530196,0.020000866,-0.014780293,0.035972577,-0.0021566027,-0.08830662,-0.056394104,0.0004970934,-0.013778079,-0.056444768,-0.03775169,0.013030028,0.03942424,0.0035296003,-0.0879332,-0.0072587593,0.03967084,0.052640133,-0.027077893,0.022037383,-0.06433233,0.016380932,0.09745181,-0.01557782,0.014924277,0.02045809,-0.12799345,0.02273831,-0.05369918,-0.093814984,-0.008885554,-0.05872617,-0.0060756346,0.016877262,0.15634213,0.00849777 +3.4.17.10,"A zinc enzyme, activated by Co2+. Inhibited by 1,10-phenanthroline and other chelating agents. pH optimum 5.6. Located in storage granules of secretory cells, and active in processing of protein hormones and bioactive peptides. In peptidase family M14 (carboxypeptidase A family).",384,1.0,-0.035238028,0.041294083,-0.1145777,-0.020182583,0.100438334,0.089583,0.0058524264,0.05496856,-0.0015190381,0.031764336,0.02864088,0.022242105,-0.006340987,0.012257586,-0.019744352,-0.006637403,-0.0019185418,0.010663762,0.016828088,-0.08212697,0.05655747,0.033215325,0.02782073,-0.0065748007,-0.04498564,-0.034979723,0.010237876,-0.005780685,0.030062346,0.007423425,-0.0269826,-0.041537043,0.06811838,0.02754718,-0.005113277,0.013035985,-0.022935107,-0.043449506,0.04209997,0.048578035,0.05146545,0.0702726,-0.059829924,-0.10439168,0.025273971,0.01646975,0.016443752,0.028333118,-0.07299375,-0.014996196,-0.072640695,-0.062049206,-0.02327339,0.031813104,-0.066300824,0.06732081,-0.05267771,-0.026362794,0.07100953,-0.03430572,0.078013405,-0.027498987,0.0524677,0.010771385,0.046809386,-0.04208055,-0.00018368528,-0.01772478,0.023286268,-0.057732116,-0.0039256727,-0.033552334,-0.016995532,0.0011156681,-0.023788033,-0.0050480845,-0.0075117988,-0.08265037,0.0076012355,-0.024134694,0.07283899,-0.03878894,0.06466219,0.115008034,0.029502006,0.042928923,-0.03592376,0.013701855,0.023137989,-0.031968355,0.045917425,-0.047173694,-0.012032481,0.06212134,-0.1342385,0.019525738,-0.0038348313,-0.024923602,-0.021121824,0.038592394,0.10065623,0.014910058,-0.01824143,-0.11047099,-0.016036132,0.054996897,0.063270256,0.07549925,0.010851018,0.06505732,-0.07646407,-0.023316948,-0.00017770375,-0.072074585,0.018863037,0.084057696,0.06937736,0.007794632,-0.037066247,-0.051023968,0.07389588,0.0056025777,0.0065453015,-0.012811755,-0.025680948,0.086919025,-0.106337145,2.7961607e-33,-0.0060463697,0.024173837,0.050712764,0.029277146,-0.02162856,0.047465663,-0.015240701,-0.0042106956,0.027392993,-0.07154459,-0.04750239,-0.05156772,-0.008764849,0.043373156,-0.04400626,-0.07824524,-0.059807234,-0.033098534,0.07134987,0.03136909,0.05089346,0.027992362,-0.050286304,0.032024186,0.06852682,0.054570843,-0.011959585,-0.016620006,0.030565776,-0.0064263903,0.012585134,-0.06927118,-0.08528832,-0.013443699,0.12317001,-0.05728458,0.0059018387,-0.05955063,-0.028759824,-0.033535644,-0.016704887,-0.04484443,0.00041726214,0.038017433,0.07567249,-0.076978184,-0.08835859,0.121664755,0.058983456,-0.012140447,-0.007051456,0.049285248,0.049253732,-0.01755086,-0.12526007,0.04546271,-0.05186624,-0.05338126,0.044172358,0.050261993,0.01708864,0.0073699574,-0.055033926,0.06238438,0.0008272675,0.01905461,-0.12751068,-0.09639767,0.042931266,0.1006046,-0.054397218,-0.045159962,0.077799186,0.041766472,0.039481565,-0.10016713,-0.0087977275,0.024840081,-0.01311562,-0.009889024,-0.012750034,-0.057266336,-0.013365924,0.047899764,-0.04276808,-0.109912805,-0.049819544,-0.038141135,-0.016015481,-0.045427926,0.005846586,0.0063492255,-0.023211597,0.05666299,-0.048419017,-4.3579477e-33,0.09328073,-0.038032837,0.044964626,0.0031980514,-0.017945016,0.019951498,0.003030736,-0.09345632,0.0110657755,-0.031260617,0.052940868,-0.013795727,0.076017335,-0.024518691,0.07471012,0.06960128,-0.05440164,0.04540145,0.054934394,-0.0024625848,-0.025068771,0.006187647,0.023918318,0.065727524,0.064158626,0.019113615,-0.02076881,0.013895531,0.07488529,0.055421636,-0.07570069,0.04512423,-0.024152871,-0.08390306,-0.098128036,0.037301306,-0.036263052,-0.024386391,-0.038763117,0.014134181,-0.001633719,-0.04704623,-0.059845295,0.082757436,0.057791702,0.08376443,-0.028441599,0.047148567,-0.040413097,-0.010395521,0.009665439,0.0112449005,-0.039147682,-0.0074102967,0.117620215,0.052863806,-0.026550103,-0.02449686,0.032698758,0.022546971,0.025604265,-0.0119405575,-0.038970076,0.016993426,0.007991803,-0.003938055,0.00481583,0.07006577,0.06996833,-0.030642997,0.06827358,0.08667766,0.06616875,-0.016222501,-0.094735734,0.026789228,-0.039796684,-0.03665339,-0.029623773,0.010477788,-0.011587159,-0.012335415,0.027476534,-0.044122186,-0.016374547,-0.08515776,-0.029534873,0.050439566,-0.050129265,0.00686789,-0.09567009,-0.04738913,-0.040635154,0.016863234,-0.057338823,-3.793275e-08,0.03901292,-0.03182075,0.065315425,-0.12512462,-0.04534618,-0.007865807,0.0380761,-0.054680746,0.012281832,-0.05085089,0.033032857,0.050470155,0.025637813,0.019579498,0.03507143,0.041166347,-0.054352175,0.101016834,-0.058721334,0.06470744,-0.013961718,0.050109185,-0.116997994,0.031575836,0.023322029,-0.07228002,0.05601873,0.070633054,-0.036364153,0.02456989,-0.013697035,0.012966298,0.06574946,-0.02716896,-0.03557066,0.07920916,-0.0467796,-0.0020155704,-0.07588007,-0.019698206,-0.055409294,-0.010759062,-0.044018757,-0.04764923,-2.0526884e-05,-0.07711758,0.0412797,0.016467119,0.014151571,0.021698004,-0.047082108,-0.01380061,-0.04182825,-0.012078376,-0.021418061,0.02805325,-0.022892471,-0.11870222,-0.056184474,-0.06454898,-0.0254378,0.062638074,0.17906676,-0.013599972 +3.4.17.11,"A zinc enzyme produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp. Its ability to hydrolyse pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumour agent. Type example of peptidase family M20",384,0.99999994,-0.07315006,-0.0165235,-0.14407659,-0.0064114793,0.0652532,0.042749718,-0.022240717,0.10919472,-0.037035767,0.006994058,0.044447813,-4.446909e-05,0.05404567,0.02601943,-0.05798035,0.013038056,-0.026922757,-0.0053308746,-0.029515035,0.011351473,-0.012988969,0.092276596,-0.033068486,0.028311085,-0.072518095,-0.044340268,0.047509648,-0.005063475,-0.004794205,0.014337165,-0.026340825,-0.021250673,0.17131737,-0.010317604,0.053227436,0.031113533,-0.017828751,0.016869793,0.06281463,0.002454572,0.024656193,0.07451155,0.03562705,-0.11477217,0.03768548,-0.05299151,0.030474143,0.042358216,0.013028562,0.0047957874,-0.08195539,-0.024345722,-0.028539402,0.054803655,-0.017219791,0.03326209,-0.06483534,-0.0035819325,-0.013491957,0.01929177,0.008055093,-0.045051787,-0.021429561,-0.0106876185,0.029124757,0.0022663984,-0.013338607,-0.07048605,0.018279226,-0.03909731,-0.016859801,-0.015739193,-0.009279914,0.032558355,-0.051366337,0.052996915,0.017212924,-0.0644976,-0.054293837,-0.025461573,0.0135210175,-0.02343291,0.0705249,0.07474031,0.070166185,-0.025982091,-0.03716723,0.019673152,0.043094106,0.029663619,0.03472163,0.0098532755,0.016397895,0.023617452,-0.14697768,0.01389637,0.0238689,-0.0759547,-0.02870412,0.027251868,0.037196092,0.025282783,0.051276464,-0.041818388,0.00343486,0.04671425,0.037305363,0.05881454,-0.0056206244,0.051242482,-0.042269472,-0.011736128,-0.0679408,-0.09898167,-0.04002969,-0.053206924,0.057441257,-0.03815549,-0.0532664,-0.024563102,0.052435674,0.0061477316,0.009358392,0.013344615,-0.0059042,0.016802004,-0.09487999,3.433522e-33,-0.03995392,0.036628302,0.0009756687,0.013300893,0.051644634,0.019922728,-0.008369847,0.023467647,0.07133139,-0.1122476,-0.06177448,0.002226195,-0.036692604,-0.0014983031,-0.09610574,-0.05458928,-0.052592546,-0.048493814,0.066732645,0.0703771,0.067590706,0.051488575,-0.012955373,-0.025764583,0.09345098,0.044465713,0.05062756,0.0052618072,0.01714781,0.010940642,-0.0045513283,-0.048621796,-0.13484931,-0.105201714,0.08673511,-0.040845852,-0.04282236,-0.057797693,0.013739348,0.0013849477,-0.06491802,-0.009884779,-0.039949775,0.04894361,0.05769978,-0.034208383,-0.04973615,0.09765126,0.0041934736,0.025161894,0.038678113,-0.028508345,-0.009698152,0.045422785,-0.10990622,-0.015384014,-0.040189765,0.027226089,0.06997184,0.09647628,0.057803515,0.051758055,-0.054017343,0.08640031,-0.09714713,-0.047852967,-0.08428747,-0.06270447,0.042225894,0.086111985,-0.017795796,0.0059112427,0.09425919,0.043626834,0.009623314,-0.13350724,-0.0008003042,0.005402159,0.01911713,0.016690632,-0.010523051,-0.05704729,0.0369973,0.022338746,-0.08838583,-0.044643536,-0.050758854,-0.051544268,-0.039624278,-0.076126635,0.028393662,-0.032482035,-0.023217047,0.068960615,-0.0109017445,-4.029765e-33,0.062395696,-0.01060613,0.04354344,-0.046134632,-0.030957446,0.0032022092,-0.003167269,-0.018389015,0.04820348,-0.014872236,0.020410117,0.019246437,0.06772367,-0.041288517,0.017401095,0.038197666,0.03442068,0.014058651,-0.016218077,-0.066706754,-0.06800751,0.058448076,-0.0009014249,-0.0135938935,0.03829721,0.03232591,-0.0814717,0.06681187,0.02431002,0.081241116,-0.014019283,0.093786135,0.0026534032,-0.11808683,-0.08533287,0.06912307,-0.040188156,0.014281902,0.0027472635,0.00088541635,0.0636859,0.016486416,0.018122036,0.071803585,-0.0077217976,0.0823636,-0.03202224,0.002260585,0.052356374,-0.028190231,0.016183326,0.027953073,-0.03163934,0.029154291,0.07385631,-0.042583335,-0.0052328487,-0.011830413,-0.052929156,-0.003856714,-0.01697264,-0.087118596,-0.008898819,0.038091745,0.03883723,0.009555814,0.017812088,0.047060452,0.11033627,0.079551555,0.08960982,0.06809309,-0.008278046,0.013018758,-0.068659686,0.085002296,-0.032489672,-0.05412922,-0.039154023,0.021558452,0.069001034,-0.03250648,0.03154189,0.05716328,-0.028801762,-0.112289965,-0.014921211,0.051922623,-0.06788162,0.05421308,-0.0052724993,-0.03729233,0.006585924,0.061672464,0.011672196,-3.647246e-08,0.046612754,-0.10530831,0.0012790438,-0.049711503,-0.025366537,-0.049530853,-0.07659656,-0.056067273,0.017795732,-0.07381378,-0.037816733,0.0781904,-0.023917403,0.06070041,-0.022300618,0.06534642,-0.042595617,0.029567292,-0.042551752,0.07410181,-0.09836119,0.06165634,-0.13719371,0.025378114,-0.012379773,-0.033199325,0.007705709,-0.014688839,-0.014265414,0.005588012,0.02369235,0.020219184,0.0027055382,0.0039100694,-0.051821183,0.04173427,0.02108093,-0.023741025,-0.059052262,-0.012229639,-0.003665093,-0.0077895406,-0.07310322,-0.008248362,0.0077200597,-0.05385522,-0.030351326,0.0076164864,-0.0026742269,-0.02167469,0.03533833,0.051399052,-0.027160019,-0.038512778,-0.038674768,0.04370136,-0.01858544,-0.04359694,-0.03240966,-0.05310311,0.016463544,0.009175354,0.2076915,0.05149353 +3.4.17.12,A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family),384,1.0,-0.00047010917,-0.05797292,-0.07909644,-0.05483321,0.033043217,0.091723636,-0.034363244,0.06441784,0.02512226,-0.008674354,0.019804599,-0.010976051,-0.035685226,0.09372152,-0.015478866,-0.010187145,-0.031831212,-0.01653885,-0.06407389,-0.064897284,0.04251075,-0.022973945,-0.024814842,-0.0070777503,-0.061486017,-0.083650276,0.034545194,-0.056426592,-0.012188734,-0.06867619,-0.01801276,-0.10623112,0.05931328,-0.027900707,0.05094113,0.044383842,-0.049722925,-0.06307732,0.04053009,-0.011324218,0.06071154,0.09105744,-0.059774615,-0.043209482,0.01740802,0.027185626,0.0496658,0.030714247,0.06399011,-0.043686733,0.0017333642,-0.038560465,-0.03292747,-0.0072116423,-0.10142344,0.059222862,-0.0066891024,0.013194601,0.00801943,0.05241769,0.0310842,0.039619777,0.07166575,-0.027246002,-0.0046509383,-0.07125362,0.0580105,0.01009607,-0.010204951,0.055078574,-0.06721113,-0.015996471,-0.045925975,-0.012029318,0.050256196,-0.014348359,-0.020170325,-0.0541906,-0.06388916,-0.023883775,0.020219903,-0.03718349,-0.0076909987,0.04622431,0.026799839,-0.033725522,0.05398241,-0.052885085,0.0861621,-0.0039324816,0.07439591,-0.075834945,0.03617297,0.07594456,-0.058964748,0.0040155556,0.013313416,-0.04643782,-0.051577155,-0.023277137,0.054290157,0.0014987277,-0.017921148,-0.06465333,0.024247095,0.075966336,0.0045271157,0.0806081,0.044817377,0.056985915,0.017011207,-0.004370921,0.062629014,-0.031783585,0.0033456094,0.048638124,-0.039861433,-0.032803193,0.006009294,0.044892073,0.011497863,-0.03718484,0.012041009,0.04239614,-0.028779283,0.09561163,-0.11819477,4.477682e-34,0.034128107,-0.01360532,0.07738534,-0.014604878,-0.02378522,-0.032822207,-0.08455426,-0.01826813,-0.040168244,-0.01082209,-0.05340683,-0.10525948,-0.025986679,-0.023235634,-0.064268574,0.023924125,-0.06739056,-0.021417268,-0.023835976,0.08000315,-0.057793673,0.011856387,-0.041297916,-0.020868879,0.1240507,0.03218466,0.017406797,-0.029294087,0.08866568,0.0010453279,-0.03980334,-0.079683356,-0.10789232,0.038077854,0.014756964,-0.032715473,0.06025074,-0.07536083,0.011874646,0.00043971944,-0.05679645,0.029989216,0.053578567,-0.08397082,0.11061026,-0.078112125,-0.024039395,0.11376114,-0.028743831,0.032236513,-0.02093065,-0.052728236,0.0642998,0.030193001,-0.050160807,-0.016270107,-0.049078833,0.00937893,0.11129506,0.033887234,0.08642008,0.021064669,-0.034340017,0.008322197,0.02204228,0.09447672,-0.10034413,-0.05490397,0.04582432,0.10463409,-0.04786665,-0.00910794,0.040223315,0.010711269,0.06848507,-0.09428344,0.020015135,0.04835591,0.041665055,0.057307687,0.054213807,0.047041588,0.016900104,-0.014816722,-0.05471653,-0.09545833,0.014754626,-0.010095557,-0.055789236,0.03938297,0.0012648861,0.013744948,0.018190334,0.07142442,-0.062735856,-6.3350196e-34,0.121331334,-0.06410524,0.051831916,0.010387453,0.003136749,0.005224023,-0.0026750022,0.012433129,0.023468796,-0.021638505,0.0029804737,-0.031096544,0.009561596,-0.03859839,0.022435702,0.018880928,-0.03468943,0.022524053,0.016948465,0.022355083,-0.05956682,0.046745066,0.009963482,0.098357424,0.04407681,-0.050845884,-0.0730657,0.09627261,0.017699428,-0.015553109,-0.044986486,0.030960469,-0.06603014,-0.0023795485,-0.12341939,0.040798075,-0.0504735,0.037585165,0.032140885,0.11125826,-0.011105943,0.03851713,0.027537983,0.023976065,-0.03272536,0.07545926,-0.035195462,0.0051189344,0.033302017,-0.06663074,0.021216767,-0.049475662,0.040340357,0.0369363,0.05194882,0.008217895,0.025741745,0.063479595,-0.026475826,0.014126823,0.024043972,-0.04601697,0.023885103,-0.009965629,-0.06166508,0.015627814,-0.06608553,0.016131144,0.11145333,-0.027883556,0.010710008,0.0051044663,0.057398446,0.031535752,-0.015582423,0.0631524,-0.09035221,-0.09900601,0.033723213,0.0013106443,-0.045433503,0.03616074,-0.03671365,-0.054038934,0.017138787,-0.032204207,0.008580639,0.079081714,0.026122574,0.055482734,0.012441916,-0.090056285,0.04187345,0.06263229,-0.0007939326,-2.4836886e-08,0.10905705,-0.004932842,0.045041937,-0.06956244,-0.06143621,0.019915106,0.025613587,-0.063068375,-0.005366211,-0.0065441113,0.01756823,-0.0061360896,-0.038221613,0.070468366,0.031335693,0.08552162,-0.06462393,0.060207885,-0.020474248,0.07274802,-0.03721165,0.04346978,-0.14380674,0.05762018,0.052809585,-0.039671414,0.056154728,0.027079452,-0.045379937,0.0028513873,-0.033568308,-0.005850086,-0.021613069,-0.024554314,-0.041760176,0.022930192,-0.08048833,0.03307336,-0.059960302,0.023033194,0.07644814,-0.077073246,-0.041497808,-0.08375433,0.0071202503,-0.0019082675,0.034290984,-0.0074028512,-0.031457376,0.051456,0.06912879,-0.014364072,-0.031755615,-0.054449987,-0.03186801,0.03934207,-0.012416141,-0.07310558,-0.04895727,-0.10803217,0.012811502,0.062427953,0.13917561,0.0026960915 +3.4.17.13,"Variants are known from various microorganisms. Involved in peptidoglycan synthesis, catalysing both decarboxylation and transpeptidation. Stimulated by divalent cations such as Mg2+ and Ca2+, but not by Zn2+. Inhibited by thiol-blocking reagents, but unaffected by penicillin",384,1.0,-0.006241256,-0.016356936,-0.03895609,0.028976526,0.017454345,-0.018388623,-0.003039797,0.07654248,0.035514593,-0.03492796,-0.0141145205,0.044164162,0.07249747,0.07695571,-0.1039436,-0.029766658,-0.04790529,0.07575931,0.032776654,-0.014457293,0.0669134,0.040976916,-0.039860774,-0.008653805,-0.014655681,0.0319601,0.031930633,0.018004697,0.038566977,-0.05335998,-0.018595418,-0.0024388174,0.024930917,-0.04674258,0.039900664,0.0388183,-0.06864739,0.026446966,0.12579337,-0.0017640705,0.015380715,-0.007736409,0.00656991,-0.021033376,0.017978417,-0.09687366,-0.023173284,0.057898253,-0.061464705,0.031550556,-0.00817487,0.007085451,-0.026795167,0.11189911,0.08207889,-0.0054420237,-0.10593458,0.027580323,0.020891162,-0.018472692,-0.02059635,0.024750097,0.036670964,-0.053439613,-0.06369283,-0.028426647,-0.016416747,-0.039253384,0.09866404,0.02105634,0.0010741187,-0.022637429,0.007762405,-0.0057300935,0.066558026,0.009986561,0.01546805,-0.021713808,-0.047695033,-0.025776666,0.07318934,-0.011696804,0.060823716,0.08663762,0.012110141,-0.040133104,0.05293205,0.03432315,0.03184815,0.035702292,0.12132265,0.047718164,0.07161162,-0.020674089,-0.0830705,-0.0652127,-0.008005787,-0.034280784,0.051367488,-0.002780717,0.010355482,0.001497749,-0.06541197,-0.0629982,0.042667594,0.06337954,0.0035189667,0.018642351,0.011156019,-0.007453976,0.031954747,-0.015363648,0.021342108,-0.017022282,-0.0052682464,0.06827687,-0.012829482,-0.06561009,-0.014249805,-0.028469743,-0.004446933,0.01540808,-0.0375186,0.0030489406,-0.04293717,0.07121541,-0.070961155,7.178681e-33,-0.039342973,0.026762968,-0.011938149,0.037109125,0.024344105,-0.0110596,-0.019014802,0.011168697,0.010259241,-0.045468092,-0.06353157,-0.087355316,-0.040123392,0.08150106,-0.03095118,-0.015432342,-0.020181652,-0.011621969,0.046603706,0.0577894,0.016561665,0.06570402,-0.04164308,-0.04027698,0.085017346,0.0867897,0.024626419,-0.027655715,0.11298363,-0.0351331,0.0034247458,-0.072165504,-0.008886737,-0.00070248,0.024258247,0.04259285,0.029382342,-0.032370254,0.015646884,0.06817038,0.022967711,0.034345627,-0.062221125,-0.055377513,0.07390672,0.016278313,-0.09754225,0.07298221,-0.04773489,-0.02014504,0.08584403,0.012439193,0.002100057,-0.014518168,-0.054710496,-0.04996807,-0.035171423,0.017458115,0.050881583,0.012534118,0.07038515,0.004232025,-0.014819281,-0.034133255,0.024153342,0.006927435,-0.04150136,-0.03388291,-0.03755692,0.073173486,-0.111139126,-0.020082647,0.07323123,0.028066196,0.033613186,-0.03601992,-0.07597999,0.035985675,0.06908836,0.020046946,-0.056564573,0.037083395,-0.020380812,-0.008120812,-0.06534089,-0.026349302,-0.040677536,-0.04732052,-0.00752481,0.05318965,-0.032125164,-0.03832032,-0.080632746,0.0786629,-0.0738523,-7.475231e-33,0.07591718,-0.082718164,0.016125347,0.002873778,-0.11572824,0.09175415,-0.08369948,-0.047891993,0.10374095,-0.063702986,0.036521222,-0.04087435,0.023700582,-0.029322768,-0.011335869,-0.03499735,-0.04352324,0.11316435,-0.09375353,0.00042196873,-0.07947443,-0.0037677549,-0.05162438,-0.0041631926,-0.0009701258,0.058695577,-0.015868993,0.05854677,0.09539088,0.069952644,0.013539176,0.012349775,-0.06623984,-0.07765279,-0.11812744,0.12124221,-0.038123883,-0.031463485,-0.0048331595,0.0026638685,0.0027582203,-0.01880883,-0.0017080628,0.104777224,0.022923805,0.042104315,0.0074854693,0.015594785,0.064922266,-0.06697595,0.037338767,-0.027792156,-0.037314326,-0.0050700055,-0.00017928991,-0.01056967,0.019115644,-0.05245816,0.0813765,-0.010313767,-0.009328964,-0.0648277,0.031041382,-0.0697679,-0.028065521,0.01671574,-0.030416885,0.046683732,0.109037064,-0.059760813,0.07475578,0.04742557,0.051129553,0.03722133,-0.00020867618,0.10256309,-0.06942914,-0.1143326,0.0090506375,-0.06459642,-0.043255724,-0.016339343,-0.02927868,0.008755649,-0.008034773,-0.032866254,-0.0011466704,0.07863567,-0.026023354,0.021564893,-0.009738055,-0.038205005,-0.003170504,0.003795708,0.008740885,-4.259122e-08,0.059803475,-0.058761023,-0.033960253,-0.009429877,-0.054651026,0.07996008,-0.051248755,-0.029005013,-0.018399937,-0.06338631,-0.032258514,-0.004524839,0.0012529915,-0.0025791426,0.01047166,0.1491159,-0.082905106,-0.019383324,-0.008321087,0.03537089,-0.13968137,-0.013493065,-0.104962595,0.045293763,-0.004425092,-0.086022,0.054224145,0.017609917,-0.06821299,-0.02094925,0.022859657,0.039206583,-0.028071988,-0.01301433,0.058025815,-0.0030072832,-0.03540804,-0.06239578,0.043141723,-0.076135315,0.050728418,-0.039038662,-0.1222452,-0.03565647,-0.052305587,-0.0635464,0.015755882,0.0005815461,-0.08954284,0.031516425,0.044355072,-0.007214431,0.007139002,-0.049089216,-0.04256042,0.049499683,0.025453746,-0.0641139,0.04739443,-0.082162485,-0.00081280916,-0.0067937747,0.18505943,0.0013060251 +3.4.17.14,"A zinc enzyme. Catalyses carboxypeptidation but not transpeptidation reactions involved in bacterial cell wall metabolism. Weakly inhibited by beta-lactams. In peptidase family M15. Distinct from EC 3.4.16.4, serine-type D-Ala-D-Ala carboxypeptidase.",384,0.99999994,-0.027712539,-0.010514786,-0.0727121,0.008059746,0.09845181,0.09569174,-0.06551292,0.05847457,-0.008419164,0.010459693,-0.057916168,-0.03160929,0.013002862,0.047617126,-0.027902948,-0.016304668,-0.07193637,0.07274992,0.0311257,-0.03836148,0.016679669,0.06258045,0.025441037,0.027201185,0.03496489,-0.03028707,0.027945245,-0.0478968,-0.052700285,-0.0135566285,-0.04028011,-0.102808654,0.048740953,-0.017148806,0.06975676,-0.009343622,0.005488591,-0.012433323,0.05589778,-0.03692492,0.018513862,0.07475668,-0.043609682,-0.043015156,0.03397108,0.028087841,0.053161792,0.037292894,-0.015514021,-0.070528105,-0.053179447,-0.06567103,-0.02658781,0.03796581,0.016304636,0.044435035,-0.019394057,-0.051883753,0.047680523,-0.0170298,0.0042609596,-0.021780487,0.057018332,-0.058636583,0.041852165,-0.036905523,-0.010828121,0.0016685151,0.015568867,-0.04450799,-0.019029647,-0.07758478,-0.036925938,0.054523185,0.0074124043,0.011952147,0.026721206,-0.07375373,0.0032565629,-0.037111014,0.010728156,-0.07102151,0.026428275,0.09473163,0.028518027,-0.01878264,-0.015711239,0.07279448,0.05936165,0.041427437,0.030811755,-0.049595494,0.03033859,0.01778953,-0.12746248,-0.03706501,-0.027518064,-0.028978566,0.019727023,0.0025696796,0.028905211,0.04071587,0.016116554,-0.10007979,0.019259745,0.07593573,0.06523809,0.099009134,0.004680028,0.029622626,0.015676625,-0.043145835,-0.029546928,0.0050704544,-0.08520159,0.046269324,0.029477883,-0.074051216,-0.09965064,0.0045768907,0.032610953,0.002121645,0.035995733,0.008746166,-0.044340026,0.08799135,-0.063035585,3.274814e-33,-0.010974842,0.013830092,0.02028152,-0.010141886,0.041502383,0.007695589,-0.045943875,0.0030976625,0.067425944,-0.03384334,-0.12425415,-0.12083857,0.005339308,0.00529874,-0.0055724196,-0.0020654772,-0.0919187,-0.05830824,0.009258905,0.05669172,0.009252641,0.03298749,-0.016944705,0.019670203,0.088975646,0.0077444273,0.034917645,-0.004678354,0.05856074,0.008479622,0.00285865,-0.08927403,-0.09933459,-0.029146701,0.11856391,-0.010721058,0.015320165,-0.088329494,-0.0009368497,0.021320658,-0.06167159,0.0025754645,-0.055985447,-0.024904631,0.06518876,-0.03425028,-0.048158385,0.08801857,-0.034585707,0.038465492,0.0594986,-0.0021436901,0.013289001,-0.024325123,-0.0664522,0.036573097,-0.050401535,0.029666035,0.111135684,0.05549754,0.04668606,0.025986893,-0.013422311,0.01376291,0.0033574372,0.03348244,-0.114582464,-0.053511996,-0.016721819,0.05365667,-0.034423675,-0.051641088,0.062532976,0.053397126,0.028985003,-0.07316576,-0.045713972,0.010226694,0.051553648,-0.061048813,-0.03344538,-0.0002725313,-0.0037228179,0.012694944,-0.0034611274,-0.0021856877,-0.04931384,-0.029767644,-0.07923176,-0.022541177,0.05703277,-0.010613659,-0.01743138,0.070015915,-0.069565915,-3.5612498e-33,0.079879016,-0.051614545,0.024084186,-0.06986688,-0.04454853,0.004421026,-0.0351275,-0.0531267,0.04712906,-0.048523065,0.058491167,-0.02027804,0.035392307,-0.002622781,0.060914043,-0.033342913,-0.0076713837,0.032416146,-0.04316235,0.00020289523,0.020666497,0.028685553,-0.022921683,0.04445746,0.0041961046,0.026696738,-0.05364549,0.09259583,0.10669329,0.02333018,0.014608863,0.06111306,-0.006789538,-0.11829538,-0.084402025,0.0765733,-0.011011046,0.015700307,-0.012798831,0.04154338,-0.015382548,0.031226717,-0.047386605,0.06935487,0.04740494,0.07073526,-0.06778069,0.01493659,0.029305223,-0.055482876,0.05328153,0.0011249895,0.009570007,-0.026479902,0.062463995,0.016490117,0.04569737,0.025780683,0.028666316,-0.017364386,0.019428609,-0.050885256,0.085438006,-0.012304028,0.05985407,0.00026570968,-0.01537473,0.044358086,0.107511625,-0.035915695,0.050464325,0.075644545,0.0066230227,0.060741432,-0.054144066,0.046722367,-0.063068695,-0.07961898,0.022570554,0.0049848123,-0.012183623,0.0099815875,0.032319766,0.018099995,-0.008424825,-0.10789168,-0.03113048,0.1271183,-0.017997783,0.046960097,-0.059171,-0.083292045,0.0076806624,0.086694896,-0.019267295,-3.7838312e-08,0.077767126,-0.030648444,0.016892264,-0.052793853,-0.06928114,-0.00908448,-0.04705733,-0.032230586,0.09257063,-0.130285,0.03882493,0.06890829,-0.017404718,0.06250506,-0.018204482,0.0836652,-0.053552594,0.031042663,-0.054036535,0.08220117,-0.08077078,0.041594326,-0.1267881,0.042693306,0.05180566,-0.11204206,0.011308413,0.10552993,-0.040843427,-0.05887373,-0.014446948,0.025219642,0.036264755,-0.04811564,-0.034064308,0.01606598,-0.015772173,-0.04117253,0.024415314,0.008687662,0.026160996,-0.045444887,-0.04572754,-0.043690246,0.020604547,-0.03131824,0.016506774,0.034247283,-0.05192448,0.015070564,0.04551309,-0.02360747,-0.055356055,-0.003839416,-0.03673796,0.044360116,-0.044545416,-0.09854287,0.006029804,-0.08471851,0.045413427,0.0042897947,0.2034097,-0.016226139 +3.4.17.15,Isolated from rat pancreas but not present in cattle pancreas. In peptidase family M14 (carboxypeptidase A family).,384,0.99999994,0.0038442998,-0.029072516,-0.12264342,-0.021659162,0.04875054,0.083268076,0.035041828,0.042769924,0.01538046,-0.025409201,0.052485246,-0.025920039,-0.026816683,0.033229433,-0.056501362,-0.03522357,-0.02422421,-0.09229496,0.063974306,-0.07044049,0.025840191,0.049595714,0.06322495,0.061305083,-0.012596428,-0.10393998,0.06761944,-0.015985578,-0.049412414,-0.056153454,-0.061923135,-0.08924833,0.044467207,-0.023483116,0.032314546,-0.038493335,0.017073097,0.020564826,0.0987455,-0.009118337,0.0862922,0.0051129544,0.048607722,-0.034621846,0.04611119,0.048432615,-0.033423617,-0.015492865,0.07718571,-0.013974296,-0.0050818715,-0.067694925,0.0139122475,0.045579363,0.05391909,-0.038676906,-0.0327636,-0.031481877,0.023224836,0.06860172,0.002207507,0.077594295,0.0470497,0.0013927696,0.033984166,-0.023573032,0.010444444,0.057110917,0.022640983,-0.01029995,0.0031554361,-0.042898074,-0.028646821,0.02330279,-0.04895073,0.0766601,-0.02455933,0.022945175,-0.0105888,-0.009824396,-0.053926475,0.047630552,0.06116094,0.0006576093,-0.045648627,0.0059621944,0.017821895,0.07107248,-0.06920244,-0.1003328,-0.011672677,-0.047951497,0.04553169,-0.019222714,0.004880444,-0.11414453,0.05026792,-0.08842395,0.028638277,0.010190951,0.06889723,0.029014425,0.035138547,-0.11642003,-0.07076263,0.10926227,-0.07008287,0.0014621831,0.08689467,0.01726606,-0.019714152,0.07902261,0.034366988,-0.017425884,0.01790018,0.08232052,0.0014106977,-0.059778366,-0.022201277,0.035876732,-0.013024998,-0.017004224,0.095247544,0.026174057,0.023077205,0.07624031,-0.0041978694,1.9261944e-34,0.010575277,-0.055989306,0.046744555,0.042795822,0.019800613,0.00351871,0.01628324,0.036631618,-0.01967428,0.015776949,-0.08355612,-0.08683391,-0.010430507,0.007460728,-0.07445703,0.05141057,-0.0047094836,-0.058469404,0.051157713,-0.035042312,-0.07930335,0.09487514,0.031801656,-0.029225858,0.095360346,0.03192866,0.0026332787,-0.012696863,0.06704441,0.019743979,-0.011234141,0.004737675,-0.04311431,0.008449942,-0.008722539,-0.035109524,0.03483716,-0.11215327,0.00036294517,0.06409946,0.08128523,-0.06328949,0.042349,-0.035346504,0.08598766,0.0040132212,-0.06338228,0.005208645,0.019069407,-0.008064353,-0.025230838,-0.006981888,0.023779387,-0.024191659,-0.08111761,0.014482822,0.0163362,-0.024367243,0.09471211,0.038882077,0.036007814,0.0884207,-0.059896156,-0.02073288,0.013101305,0.059668105,-0.12056661,-0.008453408,-0.07403847,0.068141304,-0.0053976267,-0.08907923,0.0013002739,-0.07203814,0.0357017,-0.06776018,-0.0575471,0.004875258,-0.03371787,-0.0069969576,-0.0035354965,0.05133174,0.022528002,0.005707911,-0.03126959,0.0352809,0.018660132,0.042103387,-0.067302905,0.05106261,-0.03210415,0.0770021,-0.035116468,-0.05585178,0.03292765,-1.3415438e-33,0.03626014,-0.015474953,0.02452556,-0.028041149,-0.02884392,-0.011779025,0.0071190167,-0.0028889186,0.03906414,-0.019746492,-0.012900824,-0.019373996,0.0859744,-0.0656784,0.07796988,0.01982832,-0.05939797,0.066577606,-0.04875398,-0.01631865,-0.074047774,0.0014893914,0.000632406,-0.0051363,0.05546934,0.0071996576,-0.05699596,0.12501411,0.030126471,-0.085135296,-0.017211545,0.039765023,-0.03919603,-0.085572034,-0.09257637,-0.07166744,-0.085275546,-0.062778026,-0.034197856,0.026359053,-0.08838621,0.035350338,0.0019899085,0.05911164,-0.008382533,0.016119957,-0.03176466,0.021290049,0.058639925,0.015691513,-0.033680934,-0.022797903,0.02649646,-0.08199222,0.025750559,0.005585757,-0.011858604,0.013813013,0.041895572,-0.018396256,0.06284779,0.019589623,-0.016223833,-0.0074776434,0.09265111,-0.017309904,-0.079260476,0.0090801045,0.013624029,0.044738363,0.060842264,-0.013515475,0.05143033,0.039859816,-0.00492692,0.13926186,-0.09332604,-0.00055511465,0.044978265,-0.034114633,0.0045202426,-0.09297405,0.065637484,-0.012327018,-0.0085781235,-0.057814863,-0.024616666,0.045258082,0.088759154,0.010217967,-0.0082242675,-0.019357393,0.016221477,-0.03696603,0.00470275,-2.3942972e-08,0.09362866,-0.051096477,0.0028949222,-0.027480582,-0.107058965,-0.03706853,-0.014627094,-0.0012099685,0.03506118,-0.02531525,-0.038709197,-0.031802583,-0.028105713,0.053244047,0.02456362,0.06828556,-0.031668298,0.050337926,-0.017092174,0.088749096,-0.12452329,-0.011276831,-0.05843764,0.022876477,-0.04347738,-0.0774579,0.06315734,0.11318747,-0.013854722,-0.017185915,-0.056334477,-0.008374893,-0.024747608,-0.012799927,0.027117573,0.1011333,-0.0068252,0.060076796,-0.0030300182,-0.03751993,0.05026879,-0.100624315,-0.029478451,-0.070185095,-0.0772177,-0.037342492,0.028490793,0.039821796,-0.048166882,-0.032558013,-0.06414714,0.0036169207,-0.025770234,0.011317146,0.005729041,-0.05970524,-0.013033872,-0.06474421,0.042756986,-0.055911288,-0.05846534,0.04526762,0.16961202,0.08569732 +3.4.17.16,One of the renal brush border exopeptidases,384,0.99999994,-0.039689723,-0.046275157,0.0046400907,-0.046327826,-0.016034067,-0.061815288,0.08449368,0.060898814,0.021335114,0.007225321,0.05286356,-0.031992353,-0.043044068,0.07134345,-0.051469613,-0.007698578,-0.09428722,-0.027315741,0.019597955,0.019068088,0.012511431,0.04274269,0.0055846353,-0.052342355,0.004283106,-0.045080338,-0.005556698,-0.06344942,-0.0064768074,-0.051972084,-0.025049802,-0.013935319,-0.103740595,-0.057866957,0.04962059,-0.06614995,0.022417214,0.080696955,0.0028985008,-0.023515092,0.016667277,-0.034657832,-0.041835047,-0.042202853,-0.025214873,0.096177846,-0.012462837,0.13154231,-0.0046543214,0.10721521,-0.020736698,-0.1512639,0.005356993,0.043309137,-0.052202847,0.046040148,-0.003943231,0.02259508,0.051265385,-0.014867194,0.0036545899,-0.027106551,0.050886773,-0.02489541,-0.011884104,-0.012851677,0.031953868,-0.05145562,0.036855236,-0.058392745,0.087218806,0.001893434,-0.045857336,0.009488128,0.023648066,0.08943407,-0.049368676,0.015903408,-0.062207095,-0.0046823528,0.01769776,0.047416117,-0.009538866,0.089848086,0.108091526,0.031674907,0.0034344906,-0.06745764,-0.035306945,0.029214604,0.0061794915,-0.005876113,-0.0638826,-0.0018589781,0.0026640818,-0.053645525,0.033214577,0.029127896,-0.026995376,0.012306163,-0.052912906,-0.03984586,0.08650453,-0.02422683,0.02672982,-0.04014083,0.007323564,-0.0539759,0.020768004,-0.11062285,0.0127039,-0.027432777,0.031035231,-0.03152264,0.07122884,-0.052704394,0.056985263,-0.034749076,-0.034447405,0.09616353,-0.004808557,0.06341704,-0.018828286,0.01569835,-0.026320387,-0.0064153546,-0.063908055,-2.5668225e-33,0.02173161,0.033257704,0.01602307,-0.017860765,0.010776153,0.10854555,0.083414555,-0.019199105,-0.04840522,-0.03141168,-0.07080482,-0.054964826,0.07748799,-0.008762652,-0.055130944,0.049587455,-0.049607735,0.032209285,0.060412783,-0.06567995,0.08878122,0.09575671,-0.040051762,-0.011048774,-0.039574813,0.008710413,-0.060136024,-0.029754184,0.043568186,0.0489921,0.034218784,-0.0041323286,-0.06268921,-0.023087015,-0.051755678,0.016368689,0.09850922,-0.108884454,-0.011933113,-0.008002567,-0.02299483,-0.00043119182,-0.0077460054,-0.07042476,0.053350013,-0.078915626,-0.07453695,0.047178593,-0.036177937,0.051962093,0.052031375,0.027640734,0.16687605,0.028168598,-0.026579991,-0.061510574,-0.053881865,-0.025901537,-0.04698419,0.029884512,0.078898765,0.06919842,-0.07465862,-0.033697423,0.015908655,-0.013303169,-0.03356569,0.027801316,-0.00072163367,-0.03465262,-0.08526903,-0.046647027,0.039281998,-0.010686924,0.008356812,-0.054243054,-0.06530202,0.07893918,-0.02300557,-0.0131214885,-0.09796395,0.07226658,-0.0011548401,0.033769716,0.024876498,0.018509483,0.012386391,-0.011206407,-0.06984658,0.0022099684,0.060073115,0.019514868,-0.1248304,0.057826046,-0.029381558,8.332911e-34,0.08665656,-0.00074331043,0.031304277,0.029948795,-0.029417058,0.024095422,0.008306013,0.12111553,-0.027591752,-0.009352625,0.075158276,0.014852754,0.02409524,-0.01724862,0.04079093,-0.011038109,0.031913202,0.017175062,0.064101964,-0.07222718,0.005212131,-0.03606388,0.048521258,0.028760487,-0.007347588,0.022348199,-0.048996255,-0.041223206,-0.004196902,0.039039962,0.0019946636,0.021213712,0.0007655364,-0.043801147,-0.049150936,-0.033716068,-0.10225857,-0.050987106,0.05677462,-0.033623092,0.013488116,-0.09155098,0.1506921,0.072074,0.031717196,0.05105493,0.0058726985,0.0483695,-0.061451014,0.0122263655,0.0064229905,0.033926312,-0.039592948,0.03435374,0.021578727,-0.017250411,-0.015774822,0.03931537,-0.021112232,0.10325983,0.04922941,0.037894167,-0.06353881,-0.010115848,0.10631053,0.015922088,0.07526834,0.09041402,0.09660587,-0.020222357,0.06587073,0.021272132,0.021600321,0.01439483,0.02119708,-0.011289768,0.047304608,-0.07062154,0.025517052,-0.09579409,-0.084306665,-0.047573794,0.05805838,-0.021022739,0.07468205,-0.009433917,-0.06014579,0.051318556,0.026827326,-0.028826414,-0.057229113,0.0007199946,-0.040427092,-0.005589978,0.110073015,-1.69416e-08,0.11852028,0.039973836,0.064740784,-0.028499225,-0.044610288,-0.06676532,0.0010135992,0.103328176,-0.018633638,-0.0003547692,0.046862863,0.016262861,0.009924317,-0.020613773,0.033315618,-0.0072269933,0.008248894,0.006577891,-0.04739905,-0.1369041,-0.07577396,-0.052354068,-0.04924319,0.0061117113,0.0049811075,-0.10542911,-0.014478981,0.011184632,-0.047206756,-0.032299064,0.010185863,-0.025388828,-0.00720948,-0.064137384,-0.010080348,0.08544899,-0.071170084,-0.039591476,0.027191414,-0.040619228,-0.026994081,-0.04651683,0.0318005,-0.070426114,-0.008763285,-0.021503475,0.064676285,0.0027810573,-0.007340735,-0.021626502,-0.06601113,0.044861704,0.01717287,0.044886727,-0.10754564,0.0017174736,0.00090708974,-0.058637675,0.051000375,0.0063726464,0.00483926,0.055162907,0.051016677,0.062652014 +3.4.17.17,"Active at neutral pH, from brain",384,1.0,0.035547152,-0.10202761,-0.013021812,0.008983483,-0.010186432,0.043184083,0.10368861,0.011696615,0.012528981,0.058617007,0.083642624,-0.023802346,0.0039886576,0.08966555,0.025882775,0.018882286,-0.011648245,-0.0014299556,-0.03224065,0.030284267,-0.030487726,0.07553182,0.017153442,-0.0154581405,-0.05857601,0.0337812,0.050609678,-0.021413619,0.009331452,-0.07445624,0.04463559,-0.041050863,-0.010664325,-0.023167558,-0.05031543,0.014839187,-0.14243008,-0.033894245,0.023463748,0.022927666,0.07972462,-0.059806947,-0.007954455,-0.06968126,0.04632619,0.045441154,0.0018004791,-0.09811572,0.025437413,-0.04999603,0.0074293846,-0.023845458,-0.02085277,0.06829284,-0.122457944,0.0814828,-0.036177836,0.05956249,-0.037565127,-0.017718343,-0.06366802,-0.014113284,0.04305389,-0.021300687,0.074959576,0.033133376,-0.00858027,-0.10035353,0.0063749067,-0.018434698,-0.03370997,-0.05549184,0.09666656,-0.10948015,0.025252385,-0.016646655,0.023384532,-0.0562299,0.030773677,-0.01001796,0.037271444,-0.029931,-0.13892627,0.036633685,0.060905866,0.017124781,-0.0045421314,0.044938583,-0.07490118,0.040020205,-0.055617493,-0.016718246,-0.018453438,-0.002921484,-0.038451966,-0.016337184,-0.007343503,0.048580952,0.02393909,0.036970865,0.046023395,0.077090286,-0.0746166,0.004215533,0.02495118,0.029191574,0.04692113,0.020727295,0.045882374,0.020065814,-0.027572934,-0.0636477,0.04878024,-0.0065613114,0.049858287,0.080681525,0.0116067855,0.023063257,0.034533035,-0.11194015,0.033647783,-0.11591072,-0.018972658,-0.043364525,-0.03951773,-0.009784406,-0.045010395,-1.9231438e-33,0.08017033,-0.041337945,0.059222862,-0.008409486,-0.035446886,-0.01211641,-0.049960323,-0.05556314,0.048689783,-0.022062212,0.0013572105,0.04233105,0.006108987,0.06342161,-0.10899838,-0.0031215895,-0.036497355,-0.03684933,0.014174515,-0.02412164,0.05368219,-0.03023626,-0.050440956,-0.0052643297,-0.04104808,0.0059106965,-0.056911655,-0.0033064748,-0.061651435,-0.00035826792,-0.03767801,-0.043314055,-0.11744918,0.015355245,-0.05491034,0.047721814,-0.0062195202,0.031994604,0.054517835,-0.003360527,0.034958724,0.027066018,0.08777599,0.04570869,0.049055483,0.02908219,-0.08143332,0.056709923,0.056933697,0.04243618,-0.0013477987,-0.122710325,0.03771624,-0.02922548,-0.023284942,-0.0331286,-0.05127972,0.070801176,0.02602663,0.08512135,0.06822301,0.02741805,-0.09174663,0.031911273,-0.012163498,0.07730978,-0.09778031,-0.06677272,0.033193424,-0.029940719,0.034013923,0.05611197,0.07719977,-0.06781498,-0.034659535,-0.013857197,-0.0021893764,0.036231168,-0.039881825,0.055687893,0.06732511,-0.054473694,-0.038883116,0.06989092,-0.032997265,-0.006391195,0.03375436,-0.025558287,-0.04421091,0.0029602607,0.0062153745,-0.018321484,0.014454999,-0.02447878,-0.03281139,1.17170595e-33,0.0021342163,0.009994637,-0.05809443,0.047288712,0.04241793,0.017351953,0.09833429,0.006340434,-0.027393958,0.02727985,0.07433593,0.006907425,0.00919152,0.0025039224,0.061164025,-0.033481423,-0.028502317,0.08747296,0.060887065,0.07791562,-0.057092488,0.10783222,-0.049917094,0.067373626,0.08958569,0.04717108,-0.058313686,0.017802406,-0.08033522,0.053522363,-0.053622775,0.0866905,-0.10266346,0.011161074,-0.045614395,-0.00021458507,-0.04168269,-0.003718593,-0.070068315,0.010926351,0.014624097,0.006397574,0.079820536,0.03999142,0.018926255,0.0608124,0.002359533,-0.03850179,-0.060650483,0.06355145,-0.0047714915,0.06777334,-0.053299963,-0.01284713,0.012212819,0.07326882,-0.030378364,0.0007362773,-0.013621394,-0.09163272,-0.01687496,-0.034820613,-0.0035268248,-0.09600173,-0.08175548,0.027116485,0.058189914,0.055043813,0.07920418,-0.08774511,0.019620094,0.092093155,0.047393296,-0.05319508,-0.0050177886,0.0015042097,-0.08922038,-0.00851781,0.039901264,-0.0003722293,-0.06450665,0.03237265,-0.08989528,-0.08087582,0.03382942,0.008075678,-0.11324128,-0.033887297,-0.02868865,-0.05296394,-0.038669404,-0.027809035,-0.027659466,-0.03416507,-0.009623223,-1.4448481e-08,0.04062281,0.0066180215,0.007627649,0.015518819,0.03570882,0.01004617,0.061838847,-0.055993345,-0.011681736,-0.010612687,0.032871686,-0.037962355,0.063446194,0.0028618285,0.09291898,0.07168937,-0.017021,0.09383042,-0.04588588,-0.0232436,-0.005439754,0.010167339,-0.07692943,0.07144307,0.032031234,0.03784223,0.07752327,-0.005758963,-0.029159442,-0.047553822,0.058887806,0.021305405,-0.005356114,-0.0075945645,0.020864995,-0.022683097,0.053420212,0.047582645,-0.11414407,0.07169521,-0.08099454,-0.08375228,-0.09301493,0.0052817534,-0.018208548,0.0014988782,0.054405518,-0.0154497465,0.026506383,-0.062109444,0.060210433,-0.0077856337,0.04750309,-0.025270168,-0.030031824,0.06060182,0.014749377,-0.023069533,-0.07229935,-0.0073651755,0.10361945,0.07342728,0.05815025,-0.05124463 +3.4.17.18,Known from Thermoactinomyces vulgaris. In peptidase family M14 (carboxypeptidase A family),384,0.99999994,0.00899457,0.004035483,-0.10809557,-0.041356716,0.027810393,0.06360125,-0.015221246,0.00777389,-0.030378997,-0.0032837752,0.058360998,-0.111682504,0.04537208,0.03973384,-0.08241164,-0.0012951558,-0.0019159627,-0.04714929,-0.008387072,-0.04429568,0.059453376,0.09112166,0.012658323,0.018411582,-0.03728944,-0.036136124,-0.010476059,0.0011266458,-0.04959057,-0.02019016,-0.01335608,-0.036192928,0.0955052,-0.01439685,0.110392116,0.010823837,-0.015435444,-0.029007485,0.14612634,0.05479674,0.004880065,0.008460721,0.046389837,0.018078256,-0.025888888,0.079544164,0.015293035,0.04325927,0.09369772,-0.07765342,-0.016129239,-0.093582086,-0.0026639204,0.012970397,0.03267962,0.012548708,0.011685841,-0.04664344,-0.054896247,0.023709651,0.058562584,0.026930608,-0.012634697,-0.009404923,-0.057508662,-0.025632875,0.041218627,0.018518347,0.044159126,-0.0056327432,-0.018988797,-0.03230873,-0.032410704,0.067422874,0.009859708,0.013280796,0.024843257,-0.053238533,-0.020578662,-0.048108343,-0.024769971,-0.02016533,0.07797169,-0.015003682,-0.015301639,-0.051487066,0.11595443,-0.0052534556,0.021354042,-0.013772764,0.006581231,-0.084855,0.08210273,0.0023136903,-0.042667422,-0.02776043,0.007949063,-0.10803299,0.017204506,-0.042651724,-0.024729619,-0.03766874,-0.016598187,-0.045791443,-0.046617486,0.0642866,-0.07887099,0.024553929,0.084919885,-0.011605973,-0.03886578,0.022516338,-0.014055444,-0.035718918,-0.014220724,0.009403765,0.00023249758,-0.015912574,-0.023958014,0.0051263697,0.0012787782,0.028598642,0.0099194,0.02632351,-0.053394705,0.049467757,-0.09647298,1.8764306e-33,-0.0044531166,-0.002827602,0.05859244,0.009570157,0.06573529,0.006440369,-0.06742726,-0.03297547,0.07107324,-0.050503418,-0.05802794,-0.06055517,-0.02841701,-0.016268484,-0.05989326,0.078142285,-0.1068434,0.020296637,-0.03282411,0.10688456,-0.08401341,0.14692199,0.016748467,-0.054338958,0.044771794,0.07874819,0.034473713,-0.05164918,0.12564334,0.02066394,-0.010155468,-0.072209455,-0.17577815,0.0037042946,-0.017533224,-0.038554404,0.04385749,-0.14540185,0.004421208,0.022904683,-0.023807194,-0.003619069,0.035730034,-0.012646238,0.05194047,-0.030558426,-0.03230831,0.041651912,-0.0038493022,0.05453234,-0.011917046,-0.04560401,0.07808425,-0.013705357,-0.084678926,0.0029901804,-0.029256582,0.050305292,0.07973464,0.01878649,0.08169001,0.051155686,0.019632412,-0.00089692057,0.02070275,-0.021366801,-0.0701554,0.0015214718,0.003977395,0.06338263,-0.025263673,-0.027826177,0.0286714,0.00444425,0.06498742,-0.06771245,-0.020278953,-0.04589627,-0.05525571,0.013944865,-0.042528182,-0.0017925936,0.05736765,-0.05335147,-0.07296672,-0.0054280153,-0.0054118186,-0.0017739809,-0.017050972,0.08335075,-0.07144011,-0.0064925393,-0.021723902,0.10255078,-0.091866255,-2.5183692e-33,0.093952335,-0.04936886,0.04650731,0.023324372,-0.031859048,-0.020037033,0.010529712,0.078848295,-0.024452988,-0.024839934,0.037243742,-0.031788114,0.014202116,-0.0922718,0.060163587,0.064621314,0.011482606,0.04966373,-0.05467825,0.029508702,-0.041655347,0.011934222,-0.040936306,-0.03724345,-0.015030892,-0.018431842,-0.031263813,0.08343228,0.023498068,-0.01953412,0.025378145,0.04453156,-0.06562854,-0.10024252,-0.09999144,0.032694362,-0.003758066,-0.03434995,0.047803506,0.046934687,-0.018250082,0.06112152,-0.013895721,0.095397815,0.0027222286,0.05345448,-0.080389954,0.019768251,0.10371215,0.014143995,0.058014292,-0.070934035,0.012743007,-0.019947086,0.030920483,-0.050036117,-0.029459877,0.078308724,-0.03888079,0.057733875,0.05170155,-0.018779323,-0.008080176,0.05494029,0.04443272,0.06373215,-0.13339692,0.0018621889,0.13172093,0.043932334,0.051843848,0.009849922,-0.0029424098,0.0021215286,0.016565803,0.06420295,-0.059035514,-0.083998114,0.047340166,0.017770592,-0.007645423,0.00092842407,0.048632406,0.007972791,0.030686425,-0.095423,0.03380362,0.07585185,0.005641249,0.03679997,0.01746694,-0.021819834,0.026029473,0.08622588,-0.0009938453,-2.4541253e-08,0.14619629,-0.05039626,0.086271875,-0.037603844,-0.011798105,-0.04221387,-0.035679277,0.0074492143,0.04870857,-0.03540372,-0.006780212,0.025283989,-0.025527786,0.06442373,0.020305252,0.019803476,-0.042913776,0.015979357,0.001068952,0.048318744,-0.07941611,-0.030235674,-0.046778426,0.024957577,-0.003407668,-0.02421581,0.08632816,0.04395606,0.009296629,-0.02881083,-0.048077818,-0.01592407,-0.068248995,-0.05791252,-0.042877227,0.037922285,-0.06916466,-0.009561703,0.007335799,-0.043683406,0.095103696,-0.07457792,-0.016654447,-0.025098836,-0.022348225,-0.05206984,-0.036894385,0.022595476,-0.023763983,-0.021511951,0.037363805,0.02969731,-0.0057784463,0.020136796,-0.10200888,-0.015621896,0.0057305316,-0.05033251,-0.0030475429,-0.06809724,-0.03038579,-0.01512894,0.14002696,0.03926883 +3.4.17.19,A 56-kDa enzyme from Thermus aquaticus. Most active at 80_degree_ C. Type example of peptidase family M32,384,1.0,-0.019440783,-0.04076482,-0.11805982,-0.0746641,0.029527051,0.06056557,-0.06918311,0.011362477,-0.0035311477,0.03731774,0.051582508,-0.10720465,-0.020288173,0.06638542,-0.005372183,0.0246092,-0.099802785,-0.09333454,-0.0071618864,-0.06470256,0.050180383,0.063259445,-0.024961496,0.027605372,-0.032224517,-0.009625867,0.03796317,0.007568506,0.00688354,-0.04324674,-0.03809342,-0.0137319835,0.120879084,-0.049828198,0.08560746,-0.016468812,-0.07465962,-0.06317304,0.026037859,0.036394667,0.061417673,0.023486959,0.01718283,-0.027006753,-0.03360859,-0.023378883,0.031633537,0.03574104,0.06425968,-0.05614007,-0.008469244,-0.099284865,-0.05766682,0.057861865,-0.010707998,-0.016501384,-0.07030898,-0.02759815,0.03156805,-0.009707264,0.06161004,0.07867858,-0.02414149,-0.013161871,-0.038487744,-0.08404186,-0.0015966966,-0.03236696,0.013206805,-0.014260795,-0.03088792,-0.0755406,-0.03242415,0.031231584,0.016481876,-0.006181826,0.019952271,-0.091558315,0.0047876323,-0.034672108,-0.056254577,-0.070661694,0.039398335,0.0365527,0.011332025,-0.027689522,0.08553564,0.013139902,0.07633469,-0.028730035,0.040609594,-0.051744346,0.054408364,-0.022571295,-0.0480204,0.04165339,-0.010955591,0.010138789,0.02477329,-0.027869899,0.0112586925,-0.022310266,-0.035851665,-0.03953375,-0.002384487,0.10870083,-0.0048812707,0.06592488,0.08763831,-0.0015463779,-0.050450414,0.008813124,0.012752748,-0.02375571,0.030646445,0.019750081,-0.010368584,-0.031905554,-0.0338896,0.009251236,0.051049203,-0.018312631,0.068344876,0.062447395,-0.09426518,0.12356306,-0.08090312,6.7700866e-34,0.025241815,-0.030745871,0.043104105,-0.037165463,0.010018719,-0.062284965,-0.09743364,-0.0176646,0.0066091064,-0.03157301,-0.09386973,0.030923862,0.01123596,0.004831645,-0.07426785,0.01117546,0.020833291,0.013315139,-0.021894215,0.09867564,0.035934314,0.12083532,0.0038565944,-0.03308237,0.10731651,0.01178762,0.06110675,-0.015243597,0.08051283,0.014190929,-0.025658756,-0.1649267,-0.1755298,0.0044648796,-0.0022009641,-0.030069841,0.0038929319,-0.041212156,-0.03975873,-0.017808616,0.026779193,0.042704258,0.045007322,-0.012496529,0.077127814,0.012378426,-0.005294572,0.085571565,0.03356215,0.07420257,-0.04074063,-0.027451852,0.061253145,0.03788137,-0.053714067,0.02784221,0.039038472,0.048706554,0.10403427,0.020251371,0.0021986235,0.038154893,-0.0050714416,0.015829388,0.029248646,0.026260855,-0.08677109,-0.013537662,0.0023386122,0.090271875,-0.111060806,0.040434707,0.021052536,-0.0067890417,0.084831074,-0.15078087,-0.004911331,-0.046216972,-0.06201512,0.048633035,-0.021095594,-0.009083622,0.05035536,0.006446034,-0.07306431,-0.08389781,-0.043566585,-0.00948937,-0.07108268,0.08248701,-0.0050036535,-0.035907634,0.029318932,0.10131664,-0.022613091,-2.0532055e-33,0.07206526,-0.08561033,0.052007657,-0.051862977,-0.02909138,0.056331895,0.07232228,0.05799894,-0.025262155,-0.05439284,0.08100493,-0.00847498,0.011476599,-0.041644078,0.056109115,0.054371577,0.005983838,0.116452456,-0.0070374673,-0.018142888,-0.10640236,0.045200247,-0.0043797097,0.0075570634,0.021934668,-0.00029814753,-0.025392337,0.049460985,0.0144727705,0.00528089,-0.07365769,0.057826437,-0.039711837,-0.0061561405,-0.10494439,0.004966651,-0.0026696064,-0.03187976,0.030923449,0.025346018,0.015235799,0.081827216,0.024643075,0.09534013,-0.007099248,0.06759704,-0.03751088,0.037540097,0.019518748,-0.02405197,0.01533148,-0.06858283,0.008321947,0.019067973,0.048466448,-0.05485482,-0.0019146453,0.092404895,-0.04568305,-0.0019192692,0.047990195,-0.08500386,0.00959905,0.032474592,0.025573581,0.04422439,-0.083737284,0.028939685,0.022161042,0.03941084,0.060018957,-0.015536222,-0.008859285,-0.035200544,0.0033214628,0.007613451,-0.051705264,-0.047792096,0.037077487,-0.050867785,0.016202891,0.04239116,0.023533907,-0.0054082396,0.03432216,-0.061153162,0.059191775,0.0224582,0.021764949,0.054610927,0.039144713,-0.053579114,-0.007829685,0.08270227,0.083901145,-2.5309722e-08,0.07266273,-0.055690303,0.061851725,-0.032077316,-0.018201808,-0.011168414,-0.056122568,-0.019950336,0.06660483,-0.054605868,0.015498356,0.047387037,0.03423617,0.05286685,0.011263933,0.0018014592,-0.04685619,0.022920685,0.0038593544,0.036280487,-0.051315077,0.0040036063,-0.0752664,0.026783077,-0.037081745,-0.020371396,0.042270735,0.055475436,-0.014223355,-0.048279483,-0.03504767,-0.020963255,-0.08271197,-0.04299051,-0.0021879082,0.027771967,-0.05717498,-0.0051086717,-0.043430414,0.0026796542,0.05627902,-0.07621633,-0.039010383,-0.0412001,0.015584187,0.0021576483,-0.0045691566,0.01693474,-0.009932823,-0.012491334,0.03941139,-0.006129585,-0.019302607,-0.07936149,-0.12852809,0.008201909,-0.038246967,-0.073687054,-0.053974595,-0.1021255,0.06959323,-0.007794201,0.08892412,0.052413605 +3.4.17.20,"Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U, with activity similar to that of the more stable lysine carboxypeptidase, except that no preference is shown for Lys over Arg. A zinc enzyme, in peptidase family M14 (carboxypeptidase A family)",384,0.99999994,-0.065616235,-0.06797918,-0.08643395,0.0022848696,0.10843314,0.070302635,0.039589927,0.10017872,-0.012993723,-0.01637252,-0.03447374,-0.011609358,-0.03143458,0.06903306,-0.054299217,-0.0043912046,-0.009200655,-0.035888303,-0.018042043,-0.021213252,0.023631394,-0.004337784,-0.01280954,0.005757499,0.023081806,-0.0726023,0.04740629,-0.022947297,0.029697057,-0.0022012189,-0.009288894,-0.114076346,0.07159695,-0.038561057,0.05784233,0.042788792,-0.021910433,-0.06960406,-0.06416665,0.0011042518,0.08075145,-0.023520365,-0.094774775,-0.027584737,0.03675724,0.06054535,0.036898002,0.06742866,-0.053956456,0.115819745,0.023171412,-0.04105401,0.007231675,-0.00618987,-0.094046794,0.012036554,-0.030682696,0.030625265,0.04756766,-0.0072647966,-0.06427348,0.017306658,0.04044064,0.023273418,0.10748612,-0.05590123,0.0022050396,0.06456028,0.009843432,-0.032526486,0.038559984,-0.0035460412,-0.07412096,0.05992748,0.0040419977,0.01739239,-0.013964796,-0.13266005,-0.0049076155,-0.0014240049,0.022593316,0.040766478,0.069629535,0.03602915,0.04382401,0.049522284,-0.026536308,0.08434115,-0.07379216,-0.00372915,0.054926623,-0.063012995,0.016248822,0.059658073,-0.07020707,0.03800329,0.004074444,-0.03892321,-0.021528628,0.016144896,0.007347122,-0.0011659699,0.0077962996,-0.0951292,0.027868925,0.051183823,0.03267618,0.056221873,0.0058600414,0.0729691,0.05042183,-0.036506444,0.0046109394,-0.045927107,-0.018435583,0.046067208,-0.07573447,0.0030033544,-0.07914824,0.004071185,0.014219119,-0.004380776,-0.023893174,0.012070308,-0.0028138473,0.06965573,-0.066739656,4.428478e-33,0.009322468,0.0065979124,0.048535604,0.00094509404,0.012042492,0.051935237,-0.036217917,-0.0060448553,-0.014532444,0.014835618,0.013958403,-0.027963754,0.034860976,0.030079668,-0.05778804,-0.062175624,-0.078572445,-0.061435234,-0.003415679,0.0921239,0.016343124,0.0346892,-0.019796146,0.037758246,0.015266633,0.060811244,-0.04819431,0.042235326,0.05141269,0.028287195,-0.041724242,-0.022477536,-0.06960748,-0.039665848,0.017560372,-0.08326889,0.016412009,-0.11094819,-0.028178366,0.029547986,0.032906625,-0.05383094,-0.1231532,-0.02191805,0.1071145,-0.14066589,-0.042605504,0.11504577,-0.093649596,-0.027486505,0.07533288,-0.025031613,0.058496803,-0.09156339,-0.08203344,0.05352862,-0.071322136,0.017559009,0.027870588,0.026318425,0.078701794,0.0614949,0.0043086903,0.020386592,-0.047959138,0.024508666,-0.12089816,-0.08269293,-0.023165982,0.034050893,-0.002446937,-0.0027171269,0.010234797,0.03216252,0.02723442,-0.04108476,0.00030527933,0.09804014,0.03193544,-0.082500756,-0.047506977,-0.005781404,-0.020489415,0.025768239,-0.017909793,-0.073836155,-0.012013523,-0.028472845,-0.08371443,-0.015633294,0.033683635,-0.012288708,0.0019583455,0.009274059,-0.045349047,-5.4176327e-33,0.050429266,-0.03776754,0.032778684,-0.011604334,0.06285601,0.020208541,0.040137604,-0.053685334,0.027976617,0.008279998,0.053799782,-0.0406565,0.0049011237,0.0028137455,0.05174208,-0.0004919929,-0.050899908,0.018142262,0.0055238125,-0.0069193384,-0.0019966925,-0.001675606,0.07983502,0.021404743,0.04385395,-0.019454397,-0.07186272,0.0421495,0.07663034,0.05989643,-0.009524401,0.032249086,-0.073638834,-0.07092143,-0.08941962,0.05257395,0.022051306,-0.0004669322,0.059448138,-0.01034343,-0.06984652,-0.024744155,0.01090991,0.08565074,0.021391148,0.09613664,-0.04200155,-0.016039507,0.001562061,-0.06849518,-0.0073966905,0.015890764,-0.048615463,0.04897768,-0.04514113,0.042039506,0.030359153,-0.015501442,-0.021056639,0.0051979865,0.017104503,-0.042414263,0.014556801,0.10157512,0.039998315,-0.043798164,0.019309971,0.06424534,0.0852707,-0.07733874,0.1156472,0.02709065,-0.00090762734,-0.005276582,0.0166482,0.024486275,-0.045069326,-0.09268671,0.046570137,-0.06601309,-0.039845917,-0.018989827,-0.034536235,-0.0014883779,0.0019700343,-0.057995092,-0.009291769,0.105231024,0.009517311,0.03430998,-0.09240746,-0.020310942,-0.003627399,0.03391099,-0.030389925,-4.061492e-08,0.06913242,-0.04111283,0.027443027,-0.09054558,-0.037551343,-0.037645895,-0.05998171,-0.037825312,-0.0019382639,-0.056853373,0.013419424,0.01807994,-0.021975549,-0.029214328,0.113282606,0.05905407,-0.00064463355,0.10105395,-0.049177434,0.015752897,0.028136577,0.07212551,-0.073974036,0.07123175,-0.022775043,-0.043480136,0.071204096,0.06273107,-0.023802077,-0.0070405067,-0.010882586,0.0200965,-0.017691996,-0.041210707,-0.04236282,0.07026918,-0.033727583,0.02799383,-0.02265798,-0.012133867,0.015133805,-0.063704506,-0.03953455,-0.059157606,-0.018308649,-0.028542694,0.03742279,0.03690668,0.00057953224,0.036231283,-0.045502275,-0.061824866,-0.09636858,-0.010383552,0.018260902,0.025730569,-0.0516272,-0.09079851,0.05947129,-0.13085072,0.013867193,0.08841235,0.18206827,-0.03467514 +3.4.17.21,"A metallo-carboxypeptidase that is predominantly expressed as a membrane-bound enzyme of 94-100 kDa , but also exists in a soluble form. Hydrolyses alpha-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also gamma-glutamyl bonds in gamma-Glu-Glu, and folylpoly-gamma-glutamates. With folylpoly-gamma-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate [4]. Does not hydrolyse Ac-beta-Asp-Glu. Known inhibitors: quisqualic acid, Ac-beta-Asp-Glu, and 2-phosphonomethyl-pentanedioate. In peptidase family M28 of Vibrio leucyl aminopeptidase. The release of C-terminal glutamate from folylpoly-gamma-glutamates is also catalysed by EC 3.4.17.11 (glutamate carboxypeptidase) and EC 3.4.19.9 (folate gamma-glutamyl hydrolase).",384,1.0,-0.025600221,-0.08433492,-0.060331035,0.013144433,0.040867887,0.09521076,0.01031785,0.07824599,0.008222589,-0.022993023,0.012149137,-0.07798854,-0.0402073,0.09775758,-0.005602164,-0.0052113137,0.05325151,-0.044136684,-0.06944383,-0.0020337328,0.01986387,-0.017189832,-0.07162583,-0.054576993,-0.003052043,0.032956496,0.023877535,-0.094053745,-0.018363474,-0.009529331,-0.03192536,-0.116738126,0.03397902,-0.008974351,0.07212335,-0.0039606974,-0.11563837,-0.09084735,0.07654448,-0.09770135,0.00037082547,0.08328917,-0.00085424684,-0.052120276,-0.006410471,-0.03576299,0.05004525,0.021795334,0.010086074,-0.013120547,0.05359748,-0.04084566,0.018787613,0.037865546,-0.0759939,0.032472894,-0.069946475,-0.016079806,0.01545787,0.083577335,-0.03747806,0.05442564,0.011143317,-0.036673952,-0.034848098,0.020689856,0.021696283,0.020262366,0.04478729,0.006080574,-0.018150939,-0.025515163,0.02822558,-0.0012553816,0.039942633,0.07689161,0.05400905,-0.014057265,0.029961301,-0.12438989,0.06968359,0.007479542,0.09105399,0.040013,0.06968407,-0.018854098,0.010769141,0.052941944,0.03897727,0.011584359,0.075784445,-0.021692378,-0.019288948,-0.020618916,-0.03500263,0.004372134,0.00932702,-0.038117226,-0.028676506,0.012594334,-0.004632002,0.10284919,0.020500354,-0.07968055,0.04662411,0.06067398,-0.031394903,0.058685966,0.046059296,0.0026827515,-0.032971513,0.0028818056,-0.009088709,0.008165055,-0.024780042,0.024441201,-0.051655993,-0.028562414,-0.043441527,0.028289257,0.044411767,-0.026566908,0.004921516,0.03275192,0.02760467,0.03616059,-0.101157255,6.0481006e-33,-0.036416996,0.048097696,0.05580218,-0.04558775,0.07712471,-0.051415276,-0.04628092,0.035793513,0.02735655,0.009168994,-0.114341415,-0.10231765,0.005775554,0.00028934734,0.0020217039,-0.027260358,-0.08533818,-0.028398799,0.016000992,-0.03249267,-0.006952645,0.060000874,-0.009721854,0.012810417,0.021172399,0.044296425,-0.04342701,0.036190547,0.08899186,0.017874336,-0.047742896,-0.011185721,-0.07913891,0.019415619,0.04108641,-0.035101414,-0.018464595,-0.13263693,0.035985824,0.061486132,-0.009142448,0.021103404,-0.08372504,-0.019424343,0.08134444,-0.080472454,-0.05792309,0.067371,-0.055096243,0.020313267,0.0020288385,-0.037730385,0.013318198,0.02097128,-0.069251165,0.018909954,-0.065446936,-0.013872026,0.13503103,0.02260554,0.052350692,0.026637588,-0.04136551,-0.043655217,0.010190834,0.027524387,-0.039881486,-0.090189934,-0.012279972,0.055094868,-0.008303975,-0.008193166,0.06256661,0.0132336235,0.03236465,-0.0586435,0.023899203,0.03583227,0.04145552,0.01241154,-0.015773907,0.041834418,0.07567945,-0.002958867,0.016534513,-0.06810071,0.010465359,-0.031292938,-0.015118577,0.0035191707,0.02331729,0.028916186,-0.007635834,0.0035607067,-0.05816866,-5.4847137e-33,0.10499431,-0.054436706,-0.012321631,-0.059686866,-0.011882328,0.008905365,-0.037134558,-0.07440177,0.061163634,-0.07149113,0.064958185,0.023524396,0.05498397,-0.065152,0.008057782,0.011994472,-0.046590235,0.099748306,-0.016463827,0.007864858,0.025801152,0.008954298,0.067945346,0.095126696,0.06984815,-0.051764097,0.0071856026,0.04265817,0.07270025,0.13001838,0.044584014,0.05344681,-0.052602723,-0.114968546,-0.023672108,0.027020408,-0.007565942,-0.0037224044,-0.004838016,0.10052859,0.021299714,0.062465645,0.012965962,-0.032827467,0.012163007,0.11940914,-0.033789933,-0.014897625,0.007122366,-0.101778604,0.036317203,-0.07276809,-0.04599268,-0.021956116,0.010189695,0.05879061,0.061221585,-0.050423604,-0.03364693,0.014146279,-0.034959145,-0.023397816,0.0727274,-0.07580249,0.08166929,0.030983288,0.071045496,0.06873788,0.075957015,0.0010357084,0.032698683,-0.018632352,-0.016188154,0.06806284,-0.0033216146,0.017016055,-0.017899724,-0.05125852,0.038896356,-0.08663925,0.051343974,0.038454905,0.013879481,-0.010158749,-0.008411025,-0.06823345,-0.02330847,0.16533922,0.042533148,0.04875949,-0.04778201,-0.055340003,0.06468332,0.11728364,0.08510702,-4.8764445e-08,0.05204566,0.00824158,0.0095813945,-0.06609693,-0.006984379,0.041208386,-0.048451606,-0.073415704,-0.022884803,-0.081809916,-0.0117608365,0.004647875,-0.088123344,0.0009888011,-0.09293331,0.060354415,-0.059380382,0.064946994,-0.011033893,0.040868722,-0.047019806,0.03898296,-0.052326627,-0.0062225712,0.061814997,-0.08548026,0.01946371,0.03166124,-0.044094726,0.018680183,-0.06766517,0.049621344,0.012186255,-0.045858946,-0.002095538,-0.009756208,-0.01639514,0.0021898013,-0.062267095,0.00031122944,0.025645403,0.0057095103,0.00026330474,-0.037030704,0.03167721,0.0021922386,0.056029093,0.031676803,-0.04664007,-0.028043676,0.049506966,0.025209945,-0.059316512,-0.04864913,-0.07962869,0.0008845535,-0.076092064,-0.09135453,-0.02229499,-0.121475644,-0.035421126,-0.03139678,0.11401149,0.016997112 +3.4.17.22,Activated by Co2+; inhibited by [(2-guanidinoethyl)sulfanyl]butanedioate. Large molecule (180 kDa) because of presence of three copies of metallopeptidase domain. The product of the silver gene (Drosophila) is similar. A zinc metallopeptidase in peptidase family M14 (carboxypeptidase A family),384,1.0,-0.07870066,-0.040875558,-0.077509955,0.030823417,0.10798472,0.053781696,0.057910897,0.028311454,0.019341314,-0.020598013,0.025646366,-0.044748858,-0.024783662,-0.002801858,-0.06304211,0.07200852,0.015935777,0.042501282,-0.07710561,-0.080851994,0.12885153,0.0008819197,0.038570106,-0.062499423,-0.07097685,0.05448716,-0.033124063,-0.032839593,0.03724435,-0.035752006,-0.016209785,-0.05851228,0.014909518,0.017778289,0.004099105,-0.051202998,-0.029559435,0.041351113,-0.012704864,-0.06375855,0.06278491,0.054795507,-0.059622336,-0.024449859,-0.0019053613,0.036470976,0.021501675,0.044402838,0.008519609,-0.016489262,0.005307949,-0.06332583,-0.033553105,-0.010144766,0.0026797343,0.018452277,-0.051071934,-0.014228191,0.07818903,-0.07091609,0.07741194,-0.03634746,0.000106594096,-0.026887128,0.02116265,0.008770291,0.02855439,-0.019588439,0.041924965,-0.044326805,0.021393234,-0.04602924,-0.053897545,0.04075168,0.026034262,0.1128757,0.070086956,-0.056384448,0.023618171,-0.055455297,0.005903491,0.009530554,0.130309,0.08232642,0.052289177,0.017424706,0.018886693,0.02303752,-0.031528536,0.021507362,0.04147138,-0.072801635,-0.004180914,0.025859825,-0.1138517,0.02625852,0.017816205,-0.04872211,-0.03383074,0.028974319,0.035854384,0.042754874,-0.023929577,-0.11977652,-0.022794267,-0.0006399841,0.03322895,0.027880596,0.031224392,0.025338806,-0.048398335,0.0028808676,0.009711828,0.068019345,-0.024076445,-0.01193847,-0.0029985951,0.0044410676,-0.034815527,0.030280586,0.042033684,0.035517707,-0.061536353,0.02426166,-0.03882222,0.0077999155,-0.12100476,3.9529763e-33,0.009311338,0.035252854,0.051305346,0.027213512,0.065998286,0.009644304,-0.04061771,0.025428904,-0.014973394,0.004756959,-0.078438744,-0.09777476,0.01143328,0.041223362,-0.058656532,-0.028701844,-0.052747007,-0.037830178,0.12303058,0.011463704,-0.03165645,0.06951529,-0.017621676,-0.052614767,0.073855184,0.034077793,-0.036218643,0.021963995,0.066602655,0.01943245,-0.0029172613,-0.07702677,-0.051352497,0.013872135,0.066848114,-0.004670334,0.08111904,-0.14170888,-0.006168781,0.006950174,-0.013887705,-0.0290322,-0.09484223,0.016794877,0.09122401,-0.115030676,-0.11238675,0.097255,-0.02375011,0.0648013,-0.0021609187,-0.018443018,0.10436818,-0.03542319,-0.1012969,0.03411275,-0.07912285,-0.02606264,0.034239933,0.0014096102,0.0055705872,0.057132058,-0.052398056,-0.030620705,0.073759444,0.019745123,-0.12021479,-0.017029786,-0.07237401,0.025700854,0.016109657,-0.03350896,0.022092229,0.014174937,-0.0020256075,-0.064979784,-0.03918893,0.07587467,0.051567614,0.048307944,-0.026748938,0.018559711,0.0061154207,-0.047712386,-0.09173411,-0.021708025,-0.011255571,-0.021702979,-0.058900543,0.016608106,-0.021439407,0.010476421,-0.0088168075,0.010648469,-0.0029239806,-4.921679e-33,0.03186429,-0.03350809,0.052924603,0.008026446,0.00451814,0.00569154,-0.044235498,-0.06703614,0.0055474136,-0.051689994,0.07216428,-0.018896919,0.08223649,-0.08370369,0.044579376,0.020100022,-0.005724008,0.114695445,0.022949077,-0.003937721,-0.04047874,0.0640372,0.024740981,0.064276375,0.015201829,-0.025310753,-0.0038563134,0.08761194,0.045606915,0.059354488,0.037200518,0.08245232,-0.009226533,-0.11724837,-0.054734517,-0.006742133,-0.015821315,-0.009644621,-0.016653342,0.0384451,-0.032725118,-0.0033101505,-0.027424892,0.10384209,0.08180241,0.07610817,-0.049233314,0.020449858,0.06452869,-0.075708136,0.029589226,-0.07804286,-0.021343822,0.013201995,0.11083666,0.045286376,0.07288553,-0.009800648,0.010003388,0.03308789,0.0119413,-0.022197112,0.016664054,0.028943682,0.039869837,0.07582521,-0.01976404,0.0920683,0.06105918,-0.044093277,0.0637388,0.032576263,-0.03448486,-0.049852937,-0.12442445,-0.011718659,-0.010773263,0.021991082,-0.01495924,-0.01794079,-0.022222973,-0.009349104,0.04931566,-0.034563586,-0.03447863,-0.084002815,-0.02179343,0.13908896,-0.033338252,0.0022411172,-0.09297575,-0.0534817,-0.015034858,0.08898641,-0.012426164,-4.1602537e-08,0.025350278,0.010933165,0.07284411,-0.07031131,-0.10419554,-0.0011567895,0.021452414,-0.049366,-0.03190985,-0.091809176,0.03594573,-0.032393865,0.031804405,0.027802296,0.12293342,0.056891598,0.006836599,0.052778415,0.011005902,0.012230512,-0.04560505,-0.0047631264,-0.026785152,0.040652487,-0.0040708776,-0.112730905,0.10733359,0.036954686,-0.013918539,-0.00857843,-0.057324294,0.0020333158,0.0152176265,-0.012405914,0.0016247884,-0.008194344,-0.019562747,-0.048209015,0.02577524,-0.06486202,-0.042118266,0.047308557,-0.02529556,-0.007293928,0.011788439,-0.038303703,0.09150933,0.041788433,-0.04971872,-0.04351638,-0.010108887,8.9514164e-05,-0.04152614,-0.051343612,-0.06542063,0.028020103,-0.002112305,-0.085251875,-0.010517153,-0.062032755,-0.0037450127,-0.012630778,0.09809441,-0.01938481 +3.4.18.1,"Cathepsin X is a lysosomal cysteine peptidase of family C1 (papain family). The pH optimum is dependent on the substrate and is 5.0 for the carboxypeptidase activity. Unstable above pH 7.0. Compound E-64, leupeptin and antipain are inhibitors, but not cystatin C. Cathepsin X is ubiquitously distributed in mammalian tissues. The propeptide is extremely short (38 amino acid residues) and the proenzyme is catalytically active. Human gene locus: 20q13.",384,1.0,0.02224027,-0.014111732,-0.049258728,-0.053998515,0.07991758,0.07043583,-0.052884262,0.10954165,-0.0002029485,-0.012986631,0.012553981,-0.016973231,-0.027827924,0.04707358,-0.11935583,-0.0344593,-0.09076768,-0.007997718,0.0098557575,-0.012387106,-0.016832033,0.009394497,0.014380071,0.068075664,-0.041103344,-0.028891254,0.0142723145,-0.03983346,-0.04442975,0.027488373,-0.052653216,-0.023884,-0.012732758,-0.016548015,0.018666692,0.020464228,-0.0044109803,-0.0703434,0.031038279,-0.040337425,0.061742473,-0.034293935,-0.04872392,-0.04933772,0.022522697,0.027129218,-0.0033504432,0.04986827,0.011186956,0.04317178,0.022585357,-0.036809713,0.018334134,0.030363698,-0.023112854,-0.04968445,-0.044036124,-0.03456989,0.025305314,-0.023061357,-0.013042933,0.020024497,0.031392895,0.026369942,0.046077605,-0.07414254,0.005465173,-0.019325254,-0.0064151166,0.03499713,-0.013439478,-0.028396565,0.008628061,0.049908936,0.05156384,0.07714051,0.028266693,-0.07863934,-0.058857042,-0.071397744,0.07345741,0.009909756,0.049099907,0.15414289,0.031226903,-0.028308135,0.042020846,0.018616453,-0.02354164,0.023404324,0.04461609,-0.040404025,0.0244617,0.009654135,-0.06511794,-0.032557417,-0.0021116242,-0.0601076,-0.03710257,-0.042835522,-0.03161777,0.032842282,0.05991861,-0.063623495,-0.051255226,0.03265439,-0.05899428,0.064369656,0.067319185,-0.05688876,0.030377565,-0.060389835,-0.014529582,-0.036901087,0.035569124,0.055831805,0.00092027424,-0.041038603,-0.046975326,0.010405072,0.039507125,-0.040593784,0.024081869,0.0772009,-0.063632816,-0.031158652,-0.1011991,4.4177634e-33,0.0018123478,-0.0112534,0.053751387,-0.04002236,0.07888042,-0.010031128,-0.02740275,0.016835004,-0.032774817,-0.030085223,-0.10327172,-0.09077621,-0.008112929,-0.02870557,-0.07452852,-0.016632259,-0.11364328,-0.034069024,-0.019256022,0.010386603,0.026990036,-0.009383951,-0.021624431,0.0046167397,0.09826724,0.051736373,-0.060913548,0.002697371,0.015683908,-0.004887831,0.008384714,-0.054793496,-0.08993783,0.05457094,-0.025323743,-0.010128115,0.0771776,-0.10925485,0.080308095,0.07609823,-0.011310787,-0.0463034,0.0462067,-0.09644733,0.08014597,-0.066044256,-0.031639587,0.0044262744,-0.08155327,0.033238187,0.10782764,-0.075573735,0.04070938,0.0023026832,-0.06808569,-0.031156586,-0.073211916,-0.01239082,0.025099142,0.08153729,0.10071699,-0.00048512715,-0.02380264,0.0043044547,-0.04284665,0.0019324624,-0.0545324,-0.08634515,-0.006568956,0.111900374,0.02096739,0.004211209,0.117842905,-0.025561737,0.08777809,-0.030133232,-0.02293152,0.15271807,0.0055800173,0.13849352,-0.035930444,0.006753933,-0.09723146,-0.010031373,-0.050859217,0.027281817,0.040644933,-0.004296872,-0.06673449,0.045155916,-0.0012588263,-0.014081679,0.005952294,0.03106121,-0.056150995,-5.8307176e-33,0.023955544,-0.05987424,0.06828258,-0.024988757,-0.03046962,0.055179656,0.050785773,-0.0060578757,0.039358277,-0.06624854,0.04395555,-0.017814422,0.03830492,0.02225809,0.05749218,0.05931695,-0.075960256,0.04104876,-0.0046402584,0.015209482,-0.04769633,0.0018496985,-0.027073178,0.11430247,0.12510835,-0.033537563,-0.06502495,0.007052947,0.042879872,0.017189868,-0.06515594,0.010115866,-0.06700495,-0.08188741,-0.029947557,0.05397484,-0.10646629,-0.03186594,0.028623328,0.026787948,-0.060186718,0.03256079,0.01628302,0.054470327,0.019615319,0.08484445,0.0012718189,0.016873932,0.07175498,0.026891693,0.01934855,0.020242913,0.028042382,0.04034564,0.0048021865,0.11519895,0.01897902,0.0678721,0.020230118,0.046288878,0.025626782,-0.022542892,-0.0049036467,0.08136905,0.017438492,0.004733671,-0.04091509,-0.023417559,0.06421209,-0.05964068,0.0487036,-0.06038336,0.046781357,0.030198218,-0.050513733,0.008026834,-0.019867072,0.017517928,0.03582754,-0.032677643,-0.013860731,-0.00018323184,0.026621599,-0.007134564,-0.043540806,-0.052662432,-0.0016040124,0.115831256,0.006803676,0.038792815,0.016841855,0.0058845854,0.035817362,-0.017402738,0.023685172,-4.62276e-08,0.101530865,-0.06176433,-0.0064322725,-0.10804051,-0.0128147965,-0.032250706,-0.017691063,-0.061520923,0.016531877,-0.006789999,0.023080692,0.022260688,-0.036444556,0.003655336,0.020764813,0.0073894877,0.005104058,0.06334926,-0.0051795915,0.066165246,-0.08569239,0.016222283,-0.12499044,-0.028836844,0.01076248,-0.064542435,0.0008257441,0.029547563,-0.07205016,-0.016479902,0.009671712,0.0010907828,-0.0053821444,-0.053381085,0.02466118,0.09518675,-0.049944796,-0.034055777,-0.0032796923,-0.039572835,-0.0036436128,-0.0708385,0.01966089,-0.08071252,-0.054201562,-0.022699527,0.12091235,-0.025057184,-0.010508419,0.039554555,-0.0047212252,0.011253459,0.025688339,-0.09128118,-0.0075450577,0.030063637,0.008894107,-0.097727425,0.052858304,-0.101747476,0.027802246,0.04858127,0.18478999,0.015876304 +3.4.19.1,"This is a bifunctional serine protease that has exopeptidase activity against Nalpha-acylated peptides and endopeptidase activity against oxidized and glycated proteins. In its exopeptidase mode the enzyme cleaves an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. This class of enzymes is evolutionary deeply conserved and is found in bacteria, archaea, animals and plants with different quartenary structures. In humans, malfunction is linked to different types of cancer and sarcoma cell viability. In peptidase family S9 (prolyl oligopeptidase family).",384,0.99999994,-0.01672827,-0.078505725,-0.15203737,-0.04676592,0.10681018,0.0784239,0.026544726,0.11344909,0.0958462,-0.006644343,0.02431506,0.08412456,-0.06678763,0.06825271,-0.010313722,0.037942193,-0.097626776,-0.043137774,-0.013908675,-0.06292543,0.08496307,0.048218694,0.021297095,0.025474768,-0.03968183,-0.033818576,0.0037394024,-0.07637794,-0.057146594,-0.04333244,0.045034733,-0.116264924,0.0023055596,-0.0040075,0.08159822,0.028282568,-0.025633303,0.015959894,-0.02099579,-0.040911507,0.03553011,0.01207196,-0.062073763,-0.071107194,0.011010105,0.0010677633,-0.008407683,-0.033657108,0.076626524,0.11351769,-0.045293625,-0.09953053,-0.04147318,-0.038324468,0.075948834,0.06059156,-0.080182984,-0.05468329,0.039496336,0.019768339,0.060583428,-0.0127777755,0.027035218,-0.022140171,0.012521325,-0.07222268,0.02501431,-0.06732925,-0.024791738,-0.013077667,-0.0070630494,-0.026392745,-0.053067002,0.12376076,-0.028025635,0.061967686,-0.023892255,-0.014246549,-0.03167106,0.012303813,-0.009171691,0.04148223,0.08665368,0.08021326,0.08600048,0.028372576,0.053250633,0.045217153,0.107187204,-0.034400918,-0.017337915,-0.022218376,-0.0031515297,0.010174263,0.012901351,-0.042943913,-0.03148865,-0.083868675,-0.062092017,0.011825461,-0.008323609,-0.0073847226,0.025465002,-0.10019437,-0.034316387,0.049751755,-0.040352117,0.08446624,0.00014918069,-0.038188774,-0.008860287,-0.04535054,0.02775949,-0.02267265,0.0073934277,0.043201335,-0.050358646,-0.067845464,-0.03279615,-0.0011108414,0.03802834,0.014486024,0.047881376,0.07686545,0.013713325,0.12189604,-0.07539445,3.6948197e-33,0.07050024,0.010463228,0.069669634,0.021181371,0.035364952,0.016067894,-0.016312534,0.0042650416,-0.013403761,-0.012571864,-0.034849413,-0.0772754,0.022271043,0.0010186912,0.0118577005,0.03637995,-0.033859912,0.018429115,0.009218872,0.03598021,0.00467886,0.07766324,0.047186654,-0.041947704,0.024399804,0.014754246,-0.029848784,0.0094909845,0.0870375,0.0058691795,0.018777747,-0.035678588,-0.092958786,-0.013434066,0.023104629,0.02133372,0.032807548,-0.07253881,0.046757407,0.10984886,0.017259821,-0.0044905078,0.002166109,-0.030555325,0.050938364,-0.12427624,-0.03395752,0.074511275,-0.014872295,0.031192731,0.030855307,-0.043787777,0.049224444,0.033778276,-0.05687016,-0.0040327767,-0.048024144,0.04596807,0.060620453,0.075836785,0.034609318,-0.04072359,-0.028344415,-0.052787293,0.016588919,-0.044106416,-0.0285801,-0.0045514004,-0.020709416,0.0472214,0.013544161,-0.010185672,0.100076824,0.0650918,0.011789907,-0.10656009,-0.07309627,0.09578999,0.02403571,0.05994472,0.020114945,0.043017447,-0.042625632,0.0407788,-0.08079771,-0.036091663,0.020178368,-0.06533017,-0.12554349,0.04049072,0.033031993,-0.028659392,-0.014329091,0.054015063,-0.08279096,-4.474963e-33,0.061785713,-0.059378996,0.015697159,-0.060427133,-0.05655738,0.035378315,0.0039513186,-0.0036866975,-0.01871234,-0.026693208,0.052838888,-0.031391587,0.104558714,-0.05197405,-0.024761628,-0.04664303,-0.029270094,0.06343314,0.012248611,-0.053068224,-0.003462886,0.049280476,0.03151505,0.015332693,0.031496502,0.04486165,-0.061460502,0.08833303,-0.03978636,0.0034444856,-0.029525347,0.063992746,-0.05120489,-0.06464748,-0.05565946,0.058466155,-0.09242333,-0.024883213,0.057081897,-0.052670177,0.020423803,0.060979314,0.057520505,0.069477126,0.033270754,0.04578786,-0.02426602,0.041217845,0.045560937,-0.05369526,0.004088658,-0.07419162,-0.0062638125,-0.029376578,0.029441021,0.029215347,-0.037725218,0.010360188,-0.085701466,0.03869335,0.0044970145,-0.0032083034,0.03978132,0.066152014,0.062393673,0.037624918,-0.04192427,-0.027034529,0.058234975,0.00990933,-0.01083872,-0.049653128,-0.008846527,0.016718319,0.0022584184,0.013133516,-0.06816208,-0.0029213943,0.032950297,-0.034877267,-0.05967225,-0.039902955,0.0012440847,-0.09163505,0.013961538,-0.0011078743,0.0036839652,0.11187733,0.044682577,0.031554714,-0.05394863,-0.056719083,0.026834203,0.05893503,0.02511422,-4.1600853e-08,0.09914833,-0.061871547,0.040023994,-0.11390977,-0.06626351,-0.049582984,0.019224076,-0.03498203,0.0035831674,-0.07233978,-0.018616995,0.017448325,-0.018833542,0.020779166,-0.029650114,0.1137774,-0.0019625898,0.06325517,-0.018395307,-0.034301337,-0.101286374,-0.0055019925,-0.052459866,0.022077572,-0.024172578,-0.05076381,0.019277982,0.09703627,-0.011798457,-0.004405623,-0.014888527,-0.0022178483,-0.032430265,-0.041822217,-0.030794045,0.008071029,-0.019811941,0.002194536,0.009357022,0.0022675998,0.038472388,-0.01676947,-0.052385647,-0.020852648,0.017111896,0.012929347,0.011605359,-0.032158837,-0.07971686,-0.041374657,-0.014893016,-0.005008309,-0.055232078,-0.046792936,-0.13095984,0.018562337,-0.04123879,-0.0733017,0.021962103,-0.068156116,-0.02744354,-0.004134362,0.16159324,0.038593836 +3.4.19.2,"Inactivates vasopressin and oxytocin by splitting off glycinamide. Also cleaves ester substrates of trypsin and chymotrypsin. Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide. The toad skin enzyme is inhibited by diisopropyl fluorophosphate.",384,1.0,-0.0017242858,-0.014433565,-0.05379176,-0.003258639,0.07700741,0.069802344,0.016705578,0.0022231769,-0.03987177,0.0037477529,0.093032464,-0.014262018,-0.045108173,0.1016203,-0.041535266,0.014688458,0.034214076,0.0062321797,0.0098116845,0.03655931,-0.04041252,0.025411949,0.018909011,0.026803559,0.013235567,-0.03154681,-0.0377021,0.005252228,0.0135087175,-0.058685206,-0.08561384,-0.0368526,-0.06877012,-0.0540812,0.02301613,0.018916488,-0.101622224,0.043782674,0.021454245,0.06618248,0.021397337,-0.06849816,-0.108285934,0.014549763,0.018316869,0.012758346,0.017266799,0.021699542,0.05294163,0.092378646,-0.031603865,-0.011039028,0.013972404,0.09017538,-0.015441813,0.0061796675,-0.0678159,0.078655556,0.009774016,0.003994727,-0.06960051,0.02610438,0.03105139,0.028451398,-0.05415293,-0.010652781,0.003512024,-0.04771192,0.017834222,-0.014123431,-0.0031028772,-0.07683253,0.0129064685,-0.06405482,-0.010704894,0.09471591,-0.05700427,-0.061898816,0.024138516,-0.014521766,0.08365887,-0.034580924,0.04358532,0.154332,-0.02265091,0.01810997,0.036611576,-0.052496966,-0.0159193,-0.025372213,0.068577446,0.04355688,0.00076791114,-0.03641524,0.0019258894,-0.063210316,-0.035659797,-0.0066675893,-0.056298442,0.050458327,-0.019493956,-0.027163826,-0.07517026,-0.05658844,-0.04864233,-0.018021135,-0.01385785,-0.012047458,0.04071167,-0.03384312,-0.027864726,0.0326549,0.04947726,0.007301465,-0.009279117,0.06306792,0.06756364,-0.011628304,-0.042121753,-0.009568067,0.038946133,-0.030154686,0.09399804,0.021400308,-0.068422385,-0.006208923,-0.066013865,7.965222e-33,0.07773322,-0.038456123,-0.010445509,0.013603999,-0.013904371,0.036964316,-0.06887038,0.02275087,0.03418791,-0.0364675,-0.0927242,-0.054901484,-0.045938496,0.093465276,0.021403505,-0.013040485,0.0022738276,0.022456124,0.10205727,-0.00019637212,0.08620132,0.086381875,0.001070741,-0.027838703,0.003866233,0.076079324,-0.12589023,0.054014653,-0.019713286,-0.008897479,0.09312792,-0.04916845,-0.105069175,0.011119732,-0.042542767,0.010031718,-0.040466994,-0.06951917,0.026569817,0.0047058105,-0.051763617,0.053310692,0.03732931,-0.049939163,0.07751073,-0.033535533,-0.05086825,0.04233842,-0.007385876,0.005374716,0.102939524,-0.028719213,0.04846072,-0.012671875,-0.026489817,-0.010126509,-0.039928388,-0.042184472,-0.0004643101,0.058553718,-0.05924174,0.06765063,-0.006366959,-0.059609223,-0.03694889,-0.011849293,-0.080581605,-0.08299176,-0.08604836,-0.064532705,-0.011125607,0.05586919,0.086728476,-0.047226563,-0.014389409,-0.075391054,-0.035579808,0.034060925,-0.0461927,-0.058122445,0.09814262,-0.053066485,-0.01247174,0.012110524,-0.023827324,-0.011114446,0.017300796,-0.05034083,0.011442912,0.045112666,0.049309846,-0.014229402,-0.075668335,-0.0046054483,0.018436272,-7.268817e-33,0.09781783,-0.06502295,0.01950734,-0.08608444,-0.041919712,0.07847991,0.017245147,-0.031725068,0.029270157,-0.09554538,-0.03772101,0.015099212,0.06724208,-0.017805243,-0.03538306,0.039155778,0.018202232,0.024705164,-0.026660915,-0.07477205,-0.050920345,0.01555935,0.02148704,0.020787815,0.16753857,0.0014353184,-0.001470156,0.061889708,0.011460838,0.069874346,-0.08705258,0.04945369,-0.07697274,-0.05902373,0.012354617,0.03805227,-0.11219326,0.022785809,-0.008369454,-0.026986256,0.025102938,0.021142509,0.018260086,0.017836552,0.061875854,0.12299776,-0.066350296,-0.038039885,-0.004072206,0.021838147,0.0293544,-0.052140757,-0.014575728,-0.021861494,0.103589915,0.07983498,-0.0044605667,-0.030446803,-0.007697475,-0.0141525585,0.027138092,-0.010874583,-0.017167138,-0.032603446,0.025662225,0.062177524,0.01872719,0.06383939,0.06278806,-0.041686498,0.07931414,-0.053503085,0.070488,0.030794716,-0.016514128,0.056690603,-0.0209154,-0.021253519,0.029225472,-0.019716034,-0.026696572,-0.010523566,0.03436911,-0.06936359,0.0022347425,-0.01195419,-0.019086057,0.030742716,0.002749167,0.010181931,-0.0052981726,0.017149922,0.033368275,0.049668312,0.058624204,-4.065578e-08,0.11033456,-0.07696347,0.10359985,-0.052469444,-0.0043571163,-0.008689835,0.062075574,0.028559133,0.020550137,-0.07082518,-0.0042255907,0.12107722,0.07033415,0.01154246,0.02435787,0.06651386,0.018868709,0.0044151144,-0.05922561,-0.07781447,-0.160016,0.0026616394,-0.0316453,0.03507397,0.002847258,-0.092097126,0.031321548,0.006763977,-0.0026963013,0.0176768,-0.023609208,0.009517408,0.007135018,-0.10527948,-0.003068999,0.10680868,-0.02375903,-0.0023654485,0.021753324,-0.013515374,-0.060843974,-0.030513398,-0.010860337,-0.024117326,-0.02721162,-0.043064054,0.114896804,0.016775241,-0.015115624,-0.014194516,0.038146667,0.017142437,-0.0052972413,-0.018685754,-0.107724495,-0.014646717,0.017216567,-0.011324106,0.0047740373,-0.05967881,-0.117523916,-0.011516647,0.16559441,0.013599013 +3.4.19.3,"A cysteine peptidase, known from bacteria, plants and animals. The enzyme from bacterial sources is used in protein sequencing, and is the type example of peptidase family C15.",384,0.99999994,-0.07391436,-0.060928557,-0.044451956,-0.045621354,0.05786825,0.072934024,-0.024549274,0.096457586,0.050217222,0.025176488,0.04311892,-0.020266557,0.0013356291,0.08419403,-0.08140101,0.013589868,-0.030546164,-0.017367033,0.016050557,-0.10561802,-0.0073498315,0.08796974,-0.036045577,0.10197243,-0.05183345,-0.038630273,0.037812766,-0.016657256,-0.029011551,0.011482891,-0.02523169,-0.037208688,0.08919451,-0.004065312,0.043417256,0.05649891,-0.041067462,-0.017981937,0.0878912,0.026256694,0.0094229635,0.04360433,0.025621545,-0.018778425,0.015408439,0.025614087,-0.011595787,0.06711556,0.062205605,-0.06337511,-0.04737653,-0.064652555,-0.036525328,0.00881908,0.050842214,0.00041570028,-0.046303295,-0.044981845,0.035171364,0.0054485076,0.010800774,-0.0001800465,-0.025929471,-0.03210242,-0.011615623,-0.031435553,-0.008798439,-0.025172818,0.018397063,-0.054031506,-0.029904062,-0.038077306,-0.04963152,0.10694305,-0.019600881,0.06799171,-0.009026461,-0.06908011,-0.061968084,-0.02497556,-0.018251693,-0.003782719,0.058348466,0.034319516,0.069036864,-0.002197559,0.056992874,0.055212785,0.025245573,-0.044644255,0.047832698,-0.021710776,0.030415071,-0.06101114,-0.09800095,-0.004573703,0.021540578,-0.010678165,0.09305359,0.006246256,0.028657395,0.017711107,0.011349841,-0.06233709,-0.059980534,0.04016559,0.0025023853,0.0468408,0.06444446,-0.0056558657,-0.06641005,0.020541914,-0.032016996,-0.07586394,-0.0066768373,0.013207552,0.039269693,-0.011712759,-0.021093884,0.046174966,0.030395066,-0.01584257,0.021337677,0.055510353,-0.038270406,0.070721574,-0.091160215,-7.9318685e-34,-0.008746811,-0.043330256,0.058138683,0.068571396,0.013324293,0.017568182,-0.043443494,0.002354237,0.021639982,-0.115352206,-0.019912168,-0.016791953,-0.025209755,0.018071113,-0.065649435,0.023513462,-0.070666075,-0.011411734,0.03288918,0.056593392,-0.005138101,0.053220265,0.0039615612,-0.0007451972,0.08582462,0.023855055,0.057186045,-0.0192927,0.07491275,-0.020347452,-0.076986685,-0.03302604,-0.08515927,-0.058469392,0.037694495,-0.02755619,0.027495561,-0.053915128,-0.013320889,0.060060557,-0.0059670843,0.0005969626,0.03456071,-0.055059902,0.054793246,-0.06171477,-0.08193353,0.056926046,-0.03200127,-0.018008692,0.053058583,-0.012245492,0.07014723,0.0046741636,-0.056046773,0.019604491,0.007833856,-0.008750939,0.071422964,0.07218989,0.038442034,0.0660254,-0.037083045,0.02531608,0.023666624,-0.0017458152,-0.07032003,-0.0342181,0.008930148,0.15712044,-0.023324633,-0.010906386,0.030904496,0.035190824,0.03551951,-0.11348215,-0.069187045,0.035015725,-0.0108016115,0.017425831,-0.04642946,-0.036550477,0.001090372,0.07013099,-0.08255101,-0.004613143,0.019659901,-0.0074251597,-0.102372296,-0.011863487,0.02607362,-0.059270315,0.00078961754,0.09260946,-0.051423624,-7.1335995e-34,0.042760715,-0.052375063,0.041080665,-0.05548674,-0.025428306,0.04243126,-0.0007576618,-0.05479671,0.05229624,-0.04808169,0.039477456,-0.021627074,0.04777573,0.0041550244,0.028294785,0.037889954,-0.029602418,0.0025888332,-0.0810062,0.050227255,-0.09554658,-0.026265059,0.047588363,-0.025293844,0.08603416,0.019178364,-0.046260804,0.10269397,0.0068997564,-0.019004852,-0.11834561,0.00075624045,0.024636261,-0.09810852,-0.08083091,0.05901592,-0.02109722,-0.041298576,0.012606577,0.010825187,-0.033732705,0.11160435,0.014478532,0.10394028,-0.044102006,0.08019021,-0.058008637,0.06059693,0.016330803,-0.016802168,0.012802805,-0.04951281,-0.024693875,-0.020098472,0.0023713822,-0.027496815,-0.030909471,0.0693801,0.013293578,0.03830649,0.0015470716,-0.032670904,-0.04271908,0.0636856,0.044513617,0.015999397,-0.11168819,-0.03315039,0.036734212,0.02477302,0.08750984,0.029280137,0.06560482,0.05705252,-0.023260634,0.014692892,-0.046376612,-0.009967738,-0.016333021,0.036090516,0.014645503,-0.058798168,0.005710435,0.031734068,0.003190817,-0.083396025,0.047424894,0.087828375,-0.0015465942,0.029596472,-0.014138542,-0.008299775,0.0448058,0.10736922,0.052739773,-2.7791376e-08,0.06508781,-0.11077246,0.016003551,-0.091085024,-0.05379655,-0.044015713,-0.011326191,-0.0186888,0.011344953,-0.04711905,0.003990496,0.040637814,-0.04077042,0.0981262,0.01615681,0.078955226,-0.00083283614,0.011799353,0.015422606,0.07324513,-0.114913456,0.031727843,-0.07902756,0.00080162816,-0.028202217,-0.06753952,0.043147232,0.07507592,-0.08207628,-0.017231392,-0.0036197947,0.019955333,0.0026938336,-0.045854293,-0.0046197083,0.10871768,-0.07399894,-0.029879184,-0.023782196,-0.04073553,0.02236176,-0.025479786,-0.12500176,-0.058708616,0.033465743,-0.053226057,-0.041987143,0.04343127,0.01563807,0.023664517,-0.009006027,0.0074805217,0.033873424,-0.0859933,-0.031234473,0.0030054604,0.0220218,-0.11561041,0.032710996,-0.13950421,0.026931053,0.01106307,0.19737376,0.039695032 +3.4.19.5,"Other isopeptide bonds, e.g. gamma-glutamyl and beta-alanyl, are not hydrolysed. A mammalian, cytosolic enzyme.",384,1.0,-0.014642803,-0.11695447,-0.059674133,0.029657977,-0.0133764995,-0.005545305,-0.011687162,0.0037373302,0.04974357,-0.010947366,0.06652927,0.0064023505,-0.064005755,0.099375255,-0.011291636,-0.0017958866,-0.023429325,-0.0021374,-0.033569794,0.009865452,-0.0038981468,0.032370295,-0.06188777,0.017189128,0.050619606,0.04829771,0.05758074,-0.045334753,0.027967753,-0.037080538,-0.02782115,-0.12717861,0.026698777,-0.005679398,0.06961845,0.087211944,-0.055339485,-0.059205595,0.024770929,-0.05371706,0.045156617,-0.0029613832,-0.025146618,-0.002264041,0.003073438,-0.074478604,-0.03852219,-0.05718266,0.00030066486,0.052812427,0.018610239,-0.0787644,-0.091457024,0.0139088975,-0.070138,0.011774745,-0.072164185,-0.0070813857,-0.049130738,0.03532473,-0.052300747,0.052674904,-0.023993181,-0.0060432213,-0.013347698,-0.006406409,0.021145344,-0.0038044518,-0.0022760055,-0.0140562225,-0.013490386,-0.07194418,-0.027556239,0.0018692384,-0.03896971,-0.022074398,-0.04384772,-0.011879225,0.016902473,-0.025120787,-0.0046034455,-0.08614017,0.038645852,0.116719924,0.04473931,-0.008429846,0.016659712,0.053333532,-0.0069351983,0.0056508225,-0.011441737,0.054641563,0.034595955,-0.025256898,-0.011408358,0.0004875656,0.039330244,-0.019947955,-0.045832936,0.0028438368,-0.021672167,0.07694937,-0.10237972,-0.057070054,0.034496758,0.080664866,-0.0015225824,0.01538479,0.028674714,-0.029250234,-0.040478975,0.037253253,0.04289742,0.054391563,0.032422747,-0.03665264,0.022186033,-0.033750284,-0.0016234053,-0.017946335,0.0067283893,0.014592553,0.065365195,0.07685711,-0.0035775744,0.034297723,0.025570277,-1.7518117e-33,0.048069242,0.010889319,0.07635797,-0.009859943,-0.062125523,0.07097508,-0.05665836,0.0057858424,0.035716683,-0.034279864,-0.10651403,-0.041875523,0.047417793,0.049251724,0.0637379,0.05828218,0.016892577,0.015752992,0.15200125,-0.0036705965,-0.030091386,0.08247986,-0.0064319675,-0.038729634,0.013980122,-0.021837862,-0.05135931,0.04952514,0.04502792,0.0077266167,-0.03524793,-0.027145127,-0.04462325,0.07033133,0.021787245,0.06764352,-0.03867095,-0.029561026,0.00703326,0.042199664,0.01764594,-0.04715704,0.002211175,-0.13476032,0.036255006,-0.013238721,-0.023914035,0.009930893,-0.06767582,-0.011201985,0.02718003,-0.003804696,0.044558953,0.006383383,-0.10077878,0.04691995,0.030094719,0.02580763,-0.058849342,0.086684346,-0.07758448,0.06827243,-0.0098838415,-0.024528023,-0.021189565,0.048237164,-0.072846636,-0.035744246,-0.06260417,0.047804847,-0.042545006,-0.0042587975,0.09838078,-0.0009919304,0.011965578,-0.07385096,-0.0376385,0.06327369,0.006725638,0.09414737,-0.038878236,-0.019964686,-0.016267989,0.015031608,0.008505361,0.045472242,0.092133805,0.02512535,0.04792343,0.056085195,0.042848058,-0.04521366,-0.07456547,-0.026053645,0.043530684,-1.3916945e-33,0.061886452,-0.11610903,-0.026866075,-0.024935637,-0.010276201,0.003842236,0.017785545,-0.062087078,0.024738362,-0.037613645,0.074382715,0.023337577,-0.08560813,-0.07284965,-0.007715503,-0.017128672,-0.028122298,0.09504813,0.043453984,-0.023220763,-0.03081368,0.029419474,0.005902541,0.063188136,0.104650535,-0.018977556,-0.024190346,0.016953044,0.07625229,0.05114329,-0.050243214,0.08463109,-0.010036358,-0.14384179,0.051658284,0.066357605,-0.046014745,-0.014004388,-0.025159243,-0.013775125,-0.03057817,0.1080488,0.032377657,0.045988753,0.0975223,0.12995271,-0.031148385,-0.0203365,-0.10104874,0.025984466,0.019531948,-0.053212155,-0.028853528,0.018359777,0.04972456,0.0101105,-0.058729306,0.02088909,0.056841742,-0.039063334,0.005906426,-0.012590888,-0.05161999,-0.04785515,-0.014956745,-0.0027110905,-0.024102962,0.057817247,-0.046937767,-0.026255026,0.08112561,-0.07155832,0.07226446,0.07237285,0.040573824,0.009710337,-0.05578841,-0.05430872,-0.031683017,-0.11431896,0.060415763,0.074876994,-0.0602211,-0.071830615,-0.038077723,-0.026557231,-0.008704214,0.10832224,0.023669107,0.038025852,-0.018422963,-0.0065015107,-0.019377239,0.07865294,0.075024955,-3.116304e-08,0.02997034,0.005262639,-0.00045813195,-0.080493964,-0.065525316,0.06515174,0.06325444,0.0101985475,0.043588776,-0.008116971,-0.040742934,0.042349394,-0.050649416,0.033842064,-0.11269921,0.058908727,-0.047819033,-0.028574945,-0.008126743,0.031731173,-0.1352995,0.03417141,-0.12612824,0.063237175,-0.014662854,-0.05993086,0.039966777,-0.0116769085,-0.005135834,-0.045692828,0.075209156,0.0430549,0.037751902,-0.059565157,-0.00093703513,0.04053404,0.052636966,0.016161418,0.017240614,0.015902942,-0.054733217,-0.04628893,-0.063926145,-0.029981554,0.0772953,0.0015845891,-0.02883787,0.03280269,-0.023315817,-0.012907894,-0.0063342205,-0.041315254,-0.05876662,-0.10322158,-0.03348373,-0.024802243,-0.0024089648,-0.07155184,-0.006264134,-0.0784073,0.01915088,-0.05216694,0.18187013,-0.013737236 +3.4.19.6,Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family),384,1.0,-0.0036321597,-0.04201523,-0.08563174,-0.05195086,0.11429306,0.08305707,0.048994645,0.044476956,0.030960407,0.042384118,0.07817802,0.0141521795,-0.026330007,0.038957566,0.008139078,-0.00692575,-0.07690278,-0.058079198,-0.016898632,-0.052653603,0.019067775,0.001982527,0.016939547,-0.0294588,-0.0652828,0.029315822,0.013206036,-0.0059308433,-0.0041668825,-0.009508535,0.022859178,-0.072492264,-0.03773953,-0.056454442,0.10572324,0.046673022,-0.12996508,0.0098477295,0.041287355,-0.00869897,0.072863355,-0.051795308,-0.014837446,-0.067427844,0.020203741,0.023329223,0.009521399,0.056949314,-0.024691012,0.057744574,0.029635074,-0.04660027,0.019237567,0.08531468,-0.0302939,0.037375838,-0.055162903,-0.025569867,-0.023530489,0.018582528,-0.049173612,0.01546711,-0.031613834,-0.05004943,-0.002620087,0.016833592,0.036449913,-0.05924779,0.03649376,-0.03623995,0.04009657,-0.05798134,-0.010330668,0.09829628,0.042659964,0.01772841,-0.02853386,-0.10423951,-0.026811551,-0.056896117,0.030419018,0.0220121,0.079826005,0.057800915,0.016837152,0.028068552,0.065522365,0.016069375,0.02271372,-0.020836422,0.008243716,-0.077350944,0.024896858,-0.022902086,-0.060174763,0.027815845,-0.018145652,-0.040324178,-0.05124484,0.01598864,0.035155714,0.004654841,-0.13110289,-0.0109897135,-0.055202674,0.061490867,-0.035746917,0.019032821,-0.012934343,-0.015754903,-0.014454655,0.059399106,0.019955792,-0.013617184,0.024976127,0.007845706,0.0178434,0.043500002,0.02070345,0.008101892,0.06290313,0.021073187,0.025155138,0.053691115,-0.021111729,0.0021916316,-0.16637851,7.616883e-33,0.03360464,-0.025404632,0.031051805,0.02453944,-0.008960004,0.018512925,-0.07151433,-0.011828442,0.050142776,-0.07255547,-0.11204023,-0.12175784,-0.018160453,-0.021068504,-0.053096727,-0.028798994,-0.044208586,0.043842584,0.06546026,-0.029018493,-0.024031302,0.15687203,0.036048837,0.01009005,0.04508423,0.06535788,-0.065473534,0.029826766,0.023717312,0.028537624,0.0038970849,-0.055085212,-0.059056025,-0.027510168,0.029877186,-0.0024728721,-0.0431454,-0.098876975,0.02718476,0.05711418,0.0023253702,-0.019740468,-0.010514008,0.054456968,0.034739662,-0.054507587,-0.04413477,-0.020541646,-0.051073182,-0.016483542,0.0057231043,-0.02656712,0.024862621,-0.045737334,-0.060775816,0.017066067,-0.013517545,-0.04353558,0.10196464,0.10122081,0.041821424,0.04392978,-0.021057846,-0.075949445,0.050872307,-0.038984437,-0.042568464,-0.05977887,-0.08060981,0.093699805,-0.051386125,0.024669204,0.052312188,0.021356745,0.101244,-0.042414445,-0.023516588,0.11419993,-0.004262556,-0.007542638,0.058966935,0.029019907,-0.0070686033,0.058910545,-0.07185012,-0.051225394,0.013814509,-0.079097025,-0.005333082,-0.00010305951,0.002053039,0.0033424408,-0.05827643,-0.004610077,-0.09549895,-7.920288e-33,0.021568729,-0.07553136,0.05080509,-0.02091314,-0.020790067,0.044806723,-0.0039002027,0.0026856835,0.08605056,0.025461923,0.083709106,-0.025562376,-0.08568189,-0.065768786,0.07460037,0.0073556514,-0.030965967,0.054014836,-0.027688965,0.036336817,-0.05659768,-0.021974426,0.007347753,0.06691907,0.09702068,-0.025141822,-0.039102115,0.011172408,0.07370147,0.03932024,-0.12537062,0.05422113,-0.0534675,-0.06858834,-0.020725591,-0.014103403,-0.08711417,-0.00081499206,-0.047936536,-0.025414385,0.02553072,0.024167856,0.028771725,0.053834375,0.0075294897,0.053235278,-0.035992157,0.06271423,0.015545257,0.020222815,-0.007840072,-0.094675556,0.013580679,-0.057220023,0.10183018,0.01016384,-0.0025950205,-0.03673211,0.0014691072,0.02668862,0.012927937,0.0070260223,-0.031622164,0.06624382,0.07960203,0.028930146,-0.017760083,-0.018223742,0.031763148,0.055264145,0.09185137,-0.06845126,0.09337469,0.010934428,-0.03245252,0.0495756,-0.08231771,-0.033737484,-0.007764843,-0.018129563,0.03744454,-0.008026233,-0.013720996,-0.058774125,0.030037342,-0.07497081,0.037450016,0.07734586,0.03591518,-0.0031729953,-0.019305214,0.0056543783,0.026248991,0.101973124,0.00936243,-4.39206e-08,0.057751596,-0.07460702,0.029422142,-0.05544019,-0.053612847,-0.01409545,0.05005676,-0.071814716,0.016987488,-0.014820598,0.009158172,0.054908838,0.041741736,0.0043191984,-0.028882202,0.06415579,-0.033392414,0.06561417,-0.015746716,-0.035746414,-0.07752552,0.025665443,-0.01794914,-0.030733882,0.020636434,-0.023485392,0.035336506,0.05098653,-0.03775549,-0.048411675,0.037485745,-0.018815834,0.018047154,-0.056655683,0.036830995,0.07076344,-0.06963898,0.02807224,0.022091473,0.008737089,-0.015982697,0.0022151829,-0.0065262094,0.0052920924,0.016734034,0.012883469,0.0023308673,0.05878931,-0.0065281005,-0.022284761,-0.02687588,0.018539123,-0.041571748,-0.06669224,-0.1485505,0.030892946,-0.020209579,-0.11422472,0.055856485,-0.16478026,-0.030845037,-0.013474774,0.2025863,0.043211106 +3.4.19.7,Highly specific for N-formylmethionyl peptides. Will not cleave methionyl peptides or N-formyl derivatives of amino acids other than methionine. Isolated from rat liver. Inhibited by heavy metals and activated by Cl-,384,0.99999994,-0.030244987,-0.12446973,-0.08291072,-0.013090152,0.0060353726,0.04428162,-0.0060570547,0.07535715,0.025300749,-0.0423475,0.034872673,-0.047141224,-0.055841416,0.057401005,-0.014561475,0.049771566,0.06263437,0.021125942,0.040726054,0.056721613,-0.018756526,0.057924885,-0.010069589,-0.03869373,-0.021963477,-0.019314986,0.0420795,0.0066991565,0.07635832,-0.0071127624,-0.0074763033,-0.0029416722,0.0023802419,-0.039056573,0.055624615,-0.016239095,-0.0894112,0.07166607,0.0011104937,0.0146117555,0.019589353,0.015048451,0.020470694,-0.0549758,0.043105632,-0.107625075,-0.09695465,-0.007243038,0.016706424,0.043492034,-0.039177492,-0.029696766,0.012208252,0.05557857,-0.014297784,-0.07069969,-0.111696824,-0.055719946,0.033368494,-0.030392436,-0.02288333,0.018357487,0.08872556,-0.04896768,0.010111517,0.039164905,-0.07439018,-0.04374012,0.124900766,-0.066397116,0.011670062,-0.08533537,0.0010283451,-0.009485771,-0.034751054,-0.01579507,0.032987222,-0.0654777,0.0017552804,-0.06967204,-0.011263376,0.066995025,0.06615823,0.08035126,0.051139068,0.07807613,-0.041859794,0.07681599,-0.0057934225,-0.043810595,0.026799709,-0.0031279274,0.04212835,-0.021409493,-0.07660854,0.018904733,-0.0035453553,0.081981964,-0.057994578,0.10911057,0.0080767535,0.034651455,-0.12542337,-0.042206928,-0.08670472,0.040085543,0.04657195,-0.008627881,-0.018659446,-0.052594017,-0.007652239,-0.027106801,-0.006611879,-0.04335686,-0.020704387,0.017685274,0.03662274,-0.028347952,0.07527238,0.012681992,0.00030355365,-0.0132122915,0.050146744,0.016714698,0.05135803,0.102385685,0.0068535903,2.3910971e-33,0.06762699,0.0016403925,0.075914636,0.038551047,0.040204737,-0.05768606,-0.008722851,-0.020138673,0.030248074,-0.06266818,0.014663571,-0.012159168,0.0008239717,-0.002452857,0.004764929,-0.005345743,0.026492286,-0.0031358337,0.114975266,-0.0705965,0.021624792,0.03017503,0.0400293,0.014902719,-0.0014531135,-0.04395664,-0.07390756,0.010260839,0.08959909,0.03800015,-0.0114032095,0.004794197,-0.041292265,0.014325469,0.0062814592,0.05519969,-0.08120871,-0.057537798,0.013806116,0.02288316,0.025581181,0.02111186,-0.01365314,-0.024210665,0.09084549,-0.0138859935,-0.15752509,0.07063727,-0.07779221,0.014900635,0.042207506,0.009502995,-0.0050486135,-0.004402143,-0.08642238,-0.040178493,-0.0742163,-0.08883638,0.021839308,0.107707,-0.036423087,0.010246408,-0.076192364,0.0045364257,0.031352527,-0.053677417,-0.044541433,-0.07211446,-0.06255068,0.03780504,-0.007941236,0.0015664542,-0.003912415,0.06867457,0.029652253,-0.092279434,-0.0003782052,0.05272995,0.030285133,0.057332214,0.037221324,0.056156155,-0.025126712,-0.030614583,-0.025818072,-0.0137507105,-0.0026650485,-0.069379695,0.04253321,-0.0720144,0.010926804,-0.059761833,-0.09346087,-0.01682257,-0.07228999,-3.759829e-33,0.0031635596,-0.04276445,0.015285341,-0.020514788,-0.07322176,0.0017094137,-0.08803075,-0.060738016,0.086992696,-0.021739874,0.14590731,0.002668295,0.034157377,-0.067654826,0.07230366,0.025401855,-0.022836119,0.10565941,0.012432312,-0.052275892,-0.027098043,-0.061184857,-0.046092708,0.04810164,0.08557234,-0.0140919145,-0.052625287,0.059774507,0.059203513,0.09452069,-0.035117738,0.09415434,-0.049949333,-0.03728478,0.0067711687,0.03488397,-0.10318136,0.018173156,-0.014407423,-0.049109586,-0.0059696897,0.040537626,0.012389587,0.052569587,0.0255884,0.023905767,-0.093912594,-0.011949505,0.03646103,-0.065062255,0.034672488,-0.10238976,0.0021166755,-0.07789778,0.00040888283,0.11411827,-0.002744366,0.008907022,0.008753832,-0.04381812,0.024362696,0.02540241,-0.038967438,0.0070050913,0.06807357,0.035752974,-0.0018104576,0.03252232,0.016299224,-0.08514876,0.019916935,0.0024856145,0.1020859,0.048287056,-0.024309695,-0.036718458,-0.0019415085,0.021369869,0.00829775,0.00075453374,0.014279421,0.021784725,0.013245568,-0.0062117977,0.01946172,0.0010752477,0.019733943,0.024422102,0.029251298,0.061975654,-0.07452324,-0.007854053,-0.016573388,0.036455695,-0.0037004843,-2.9809826e-08,0.099284895,-0.022790227,-0.0034540216,-0.033606224,-0.09559005,0.017525183,0.004658482,-0.088065416,-0.039147932,0.033177204,0.013697109,0.09471448,0.023493554,0.024768513,0.004710954,0.07796749,0.05161461,0.025457758,-0.05115176,-0.023863537,-0.06518288,0.056568332,0.04176761,0.018643469,-0.028457304,-0.07395917,0.0379504,0.034231983,-0.0053238184,0.004211326,-0.028337838,-0.024010379,0.048250023,-0.024339288,0.04437225,-0.0058009704,-0.08180559,-0.08153285,-0.030794576,0.09515762,-0.030158695,-0.0061648902,0.010170437,-0.02313354,0.012772934,-0.09188692,-0.0695633,0.08855999,-0.06781948,0.02726263,-0.027027223,-0.013215573,-0.015180477,-0.057633072,-0.072943844,0.02188119,-0.00059444434,-0.082236305,-0.021996444,-0.081651665,-0.06690065,-0.0015701262,0.14147365,0.0968019 +3.4.19.9,"The enzyme, which occurs only in animals and plants, can be either endo- and/or exopeptidase. It acts on tetrahydropteroyl polyglutamates and their modified forms, as well as the polyglutamates of the folate breakdown product N-(4-aminobenzoyl)-L-glutamate (pABA-Glu). The initial cleavage may release either monoglutamate or poly-gamma-glutamate of two or more residues, depending on the specific enzyme. For example, GGH1 from the plant Arabidopsis thaliana cleaves pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from the same organism yields mainly monoglutamates. The enzyme is lysosomal (and secreted) in animals and vacuolar in plants. In peptidase family C26.",384,1.0,-0.069374956,-0.08680889,-0.062141214,-0.06646784,0.053980876,0.042168174,-0.0030369514,0.07406678,0.088715054,0.025629967,0.08077064,-0.03249282,-0.0800209,0.037437055,-0.008178745,0.024984548,-0.086285874,-0.0479326,-0.054425035,-0.06399784,0.083488844,0.05326857,-0.10533034,-0.031107036,0.022277856,-0.04171666,-0.008489644,-0.068228014,0.054780435,-0.08240283,0.0065333187,-0.062735826,-0.004283114,0.026257709,0.03622467,0.10835537,-0.05840173,-0.028055362,0.08673008,-0.029287238,0.0334203,-0.006583056,-0.044246014,-0.08296092,-0.065966256,0.019126302,0.037853535,0.0618414,-0.022103634,0.020223815,0.02302411,-0.0789638,0.0069932397,0.07443185,0.01890001,-0.016977977,-0.0025936903,0.028486293,-0.06223913,0.08807048,-0.03181166,0.02405367,-0.02931817,-0.034972932,-0.0102720205,-0.043479875,0.03857962,-0.06694839,0.033639748,-0.0409355,-0.002099536,-0.026353335,-0.015317132,-0.020469815,-0.02252441,0.06677887,-0.061193734,0.014106049,-0.02214683,0.0068049007,0.072575025,0.034244288,0.085012525,0.06855424,0.039094746,-0.031269487,-0.038525153,0.11951599,0.023160882,-0.038541406,0.045067195,0.017144699,-0.017233312,0.028680349,-0.03373564,0.023764076,-0.0021766878,-0.102789454,0.011745889,-0.022355277,-0.05360938,-0.0021016798,0.0075009656,-0.07485259,-0.02397957,0.057218827,-0.03892591,0.022155195,0.022842906,-0.046346582,-0.03974219,0.06253557,0.050337344,0.019726029,-0.032387685,0.033126563,0.01711436,-0.06363803,-0.0086825,0.0214471,-0.029253522,0.024661006,0.04546628,0.06776657,-0.06800032,0.064859286,-0.10040433,2.2355777e-33,0.016002687,-0.009534268,-0.031480342,-0.023294374,-0.019396111,0.0066313823,-0.043060005,-0.03422619,-0.0025158417,-0.00089050253,-0.0812999,-0.09293227,0.0039480776,0.025151331,0.058759015,0.029496098,-0.029755512,-0.044728026,0.026270095,0.013498517,0.015719218,0.048883967,-0.073218815,0.01064138,0.032355998,0.053225588,-0.013352995,-0.035567213,0.038200375,-0.004354791,0.008616788,-0.093107544,-0.07736584,0.052980207,0.019375525,-0.014401981,-0.033516496,-0.06152111,0.0060302885,0.0125022875,-0.010059066,0.013089128,-0.03359532,-0.020380322,0.070911236,-0.047678195,-0.07878188,0.015991054,0.004206804,0.04324622,0.060922325,-0.033741012,0.07677924,0.028456904,-0.06325272,0.025806773,0.012577983,0.001993216,0.070791565,0.09657859,0.014964079,0.057325587,-0.02645804,-0.042950716,0.021134676,-0.008118551,-0.078070335,-0.05925336,-0.050744295,0.10133463,-0.047889866,-0.06363275,0.05313501,-0.003481614,0.04169042,-0.09739489,-0.023944756,0.05023995,0.050380062,0.019191736,0.059138864,0.0074591157,0.045509435,-0.054501284,-0.14101772,-0.042287048,0.039464056,-0.072482154,-0.073922664,0.0075704525,0.054476466,-0.021492692,-0.022897843,0.00016365846,0.016655972,-3.744849e-33,0.115654014,-0.036442988,0.035311043,-0.099078126,-0.042967673,0.06709942,0.0077221203,-0.035632774,0.033010338,0.0033728925,-0.010087356,0.05317592,0.015830316,0.033611037,0.02396486,-0.032374732,0.010069552,0.07791638,0.020841435,-0.07117597,-0.056884415,0.020245953,0.011885555,-0.013386076,0.10235523,-0.009474352,0.0015749615,0.09148737,0.00438019,0.04478175,-0.036144078,0.057610128,-0.020521654,-0.012993369,-0.010232498,-0.027711343,-0.09699912,-0.023376616,0.029066809,0.012057693,0.010779027,0.053428866,0.107921116,0.054357626,0.014908629,0.045950517,-0.09192515,0.0007003035,-0.06472308,-0.07437648,0.018566472,0.054089706,-0.023578662,0.015264655,0.035249237,0.0026671651,0.035354145,-0.038375225,-0.07735843,-0.0484166,-0.0055744625,-0.06970457,-0.027547022,0.05169565,0.034977,-0.018220635,0.051535722,0.010260309,0.034675933,0.068707176,0.025610693,0.035837516,0.05147053,0.00032665665,-0.040468924,0.04794743,-0.10350562,-0.084956594,0.008445348,-0.1149015,0.028902322,-0.023657132,0.018902065,-0.054202955,0.038508926,-0.15008846,-0.034758132,0.13587064,0.08766636,0.02119948,-0.061148148,-0.036304176,0.020161036,0.07495551,0.11323275,-4.6863324e-08,0.028936906,-0.048586313,-0.022476096,-0.03894988,-0.025390325,0.0066613876,-0.00036654275,-0.016710274,0.033926353,-0.03698498,-0.035519343,0.062201336,-0.055397075,0.063434936,-0.014791636,0.04803346,0.015987005,0.012911634,0.0305431,0.032232307,-0.12439791,0.009400173,-0.08470189,0.014004333,-0.0117301745,-0.023554161,0.041653965,0.07706704,-0.007139048,0.03576899,0.024922693,0.0698479,0.01085238,-0.045251824,-0.04113951,0.07145621,-0.036300924,0.01831023,-0.00017608613,0.035566986,0.06796971,0.018086893,-0.035299636,-0.035827167,0.020030752,-0.013647247,0.044071727,-0.044390634,0.019071838,0.032721646,0.043871917,-0.0008605473,-0.041225635,-0.0130909905,-0.114891715,-0.0032282397,-0.0631258,-0.030934943,0.04168148,-0.087091826,-0.04190501,0.043901525,0.20803533,0.008417381 +3.4.19.11,"A 45-kDa metallopeptidase from Bacillus sphaericus, the substrates being components of the bacterial spore wall. A member of peptidase family M14 (carboxypeptidase A family). Endopeptidase II has similar activity, but differs in cellular location, molecular mass and catalytic mechanism [3]",384,1.0,-0.010844566,-0.08356894,-0.06375001,0.0034239304,0.07343864,0.035315584,0.015258965,0.04338607,0.008566123,-0.01764201,0.03781392,-0.10864064,-0.016783582,0.083863094,-0.029579185,-0.02887158,-0.05758928,-0.025049651,0.014232346,0.025847523,0.12254205,0.020654557,-0.057418395,-0.009358102,-0.05895833,0.0065722624,-0.016080583,-0.12422951,-0.048462193,-0.0058774897,0.04016906,-0.094232015,0.06017875,-0.0665539,0.121191286,-0.00086635933,-0.01644,0.047694594,0.0845304,-0.069056265,0.021961456,0.07152763,-0.0062690694,-0.007480208,-0.013259401,0.071521446,0.06333775,0.030671049,-0.023430357,0.012840249,0.0122855315,-0.058585547,0.011757919,-0.010383558,0.021264909,0.040700696,-0.02355401,0.0111781545,0.07420633,0.016263412,0.10365841,-0.008980913,0.017364869,-0.025500407,0.016635481,-0.060301114,0.023084484,-0.028910778,-0.000113684706,-0.016401438,-0.0044047986,-0.033223037,-0.064004794,0.07174858,0.07619385,0.083283305,-0.012631353,-0.07815693,-0.04413609,-0.06161135,-0.002829515,0.01798924,0.06550169,0.032230306,0.025950924,-0.03319808,0.043137014,0.06217038,-0.005599152,0.018299917,0.044250455,-0.04065354,0.010847134,-0.023892334,-0.056158107,-0.003738038,-0.029925281,-0.029182078,-0.011877279,-0.008433784,-0.010210722,0.015292533,0.005655181,-0.07665946,0.026350759,0.020005332,-0.047294375,0.06886516,0.1029452,0.014940275,0.035145424,0.042042863,-0.0040010456,-0.050533853,0.06194472,-0.023773698,0.025772925,-0.048171844,-0.056696266,0.010556786,0.052174494,-0.024424473,-0.025852399,0.021964017,-0.02704349,0.025568407,-0.09672546,2.6957281e-33,-0.008703242,-0.026880192,0.074043415,0.00065206765,0.025912957,-0.06954205,-0.0059196292,0.008751849,0.016896171,-0.013151374,-0.111944,-0.14368041,-0.009468486,0.062404577,-0.05279305,0.019707866,-0.09268032,0.04584814,0.05091078,0.035452835,-0.04596188,0.0909874,0.0058418354,-0.020317964,0.13968924,0.040609267,0.01282966,-0.06830581,0.086709164,-0.0011525205,0.05957683,-0.08601643,-0.097054504,0.0016910143,0.058062185,-0.052281454,0.07822016,-0.11302205,-0.049819555,-0.030180676,-0.04264302,0.03160809,-0.034886822,0.021446962,0.07973473,-0.08924308,-0.023611736,0.06616454,-0.027549004,0.044352874,0.026540058,-0.018905727,0.073010534,-0.01245649,-0.0672361,0.028100958,-0.0037278747,0.052515015,0.113519,0.025522906,0.05384764,0.09245375,-0.059065204,-0.003369247,0.011239371,0.0049283383,-0.06756881,-0.02090282,0.005824873,0.031948384,-0.052105278,0.011139587,0.061580423,0.0127651235,0.0028121197,-0.041452404,-0.08170998,-0.030365022,0.017044723,0.02633731,0.029459124,0.028582966,0.035610355,-0.07388162,-0.06611552,-0.009226794,-0.033050433,-0.05200985,-0.07567993,0.022727134,-0.0034451124,-0.010651741,-0.056134846,0.07150001,-0.10495564,-2.5397503e-33,0.06972606,-0.059100457,0.050800376,-0.069655575,-0.059640735,0.018716183,-0.05705794,-0.010768324,-0.0070542376,-0.054231767,0.040997427,-0.020522537,0.08952988,0.0064481273,0.014799114,0.014488913,0.012244583,0.07876283,0.034523357,-0.067276284,-0.010378052,0.013941962,0.014247098,-0.010435415,0.06549802,0.015888764,-0.05533577,0.13101162,0.06292652,0.008742613,0.015623849,0.035828244,0.047529306,-0.07915511,-0.08347477,0.05822143,-0.052162506,-0.034532845,0.03682098,0.0013774007,-0.012703544,0.018594481,0.025925407,0.09324802,0.00909341,0.05457764,-0.0299319,0.063052244,0.064933635,-0.0777271,-0.003056033,-0.058346637,-0.012126843,-0.0578041,0.062398,-0.01783454,0.0060510077,0.06649635,-0.020197708,-0.043536615,0.015136352,-0.00212109,0.06912993,0.04643493,0.073313974,0.06991338,-0.0147580495,0.061449707,-0.0051395795,-0.048391614,0.02701156,0.011220359,-0.023080103,0.030108273,-0.036271036,0.0016453952,-0.034568943,-0.025969133,0.04130839,0.06747994,-0.013519946,0.0022960622,0.048721258,-0.0030545334,0.09406372,-0.048312493,-0.025537308,0.09398844,-0.0069050044,0.023423184,-0.08287783,-0.04256949,0.075202726,0.046025764,0.023431852,-3.4820147e-08,0.08109866,-0.02751944,0.06260302,-0.12725642,-0.05994531,-0.03249942,-0.0027633507,-0.028493876,-0.009821041,-0.12543076,0.050205078,-0.032696594,-0.025545267,0.030917402,0.03134862,0.06620329,-0.04344063,-0.030516826,-0.0070514097,-0.0010004853,-0.068044625,0.0030246272,-0.09754262,0.016206812,0.025548266,-0.06001136,0.042355634,0.07712454,-0.03881581,-0.0052088303,-0.014720057,-0.012799461,-0.06620655,0.01616265,0.003232818,0.043868426,-0.112409435,0.057029795,-0.007798969,0.013981221,-0.012756254,-0.08042092,-0.044949565,-0.022732604,-0.011499299,0.03320956,-0.03290263,0.06582678,-0.052076045,-0.081927344,0.020738712,-0.037825752,-0.051848527,0.0031391806,-0.085207015,0.050657853,-0.011175445,-0.06592854,0.008123609,-0.058835838,-0.001978268,0.05116981,0.1265646,0.047169674 +3.4.19.12,"Links to polypeptides smaller than 60 residues are hydrolysed more readily than those to larger polypeptides. Isoforms exist with quantitatively different specificities, amongst the best known being UCH-L1 and UCH-L3, which are major proteins of the brain of mammals [1]. Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). Ubiquitinyl hydrolase 1 is the type example of peptidase family C12, with a similar protein fold to papain and catalytic amino acids Cys, His and Asp. There is a separate family (C19) of enzymes that also hydrolyse ubiquitinyl bonds, and it is thought that all the ubiquitinyl hydrolases are also ubiquitin thiolesterases (EC 3.1.2.15)",384,1.0,-0.01878107,-0.124846995,-0.05687925,-0.037628487,0.06921855,0.06854919,-0.021098904,0.041923057,0.020991046,-0.007343695,-0.004621023,-0.024975248,-0.072475776,0.06759273,-0.04551678,-0.011871983,-0.097960204,-0.059668235,-0.0020099885,-0.064150184,0.040301647,0.014853156,-0.04092374,0.05315605,0.021139394,-0.021431632,0.044873033,-0.038036935,0.05862235,-0.09910979,0.0350039,-0.11394333,0.038671456,-0.04515356,0.08699104,0.06694304,-0.061473202,-0.022440955,-0.049480103,-0.029923115,0.09311208,0.020181473,0.038438108,-0.03145092,-0.011105013,-0.035347503,-0.055136267,0.026826007,0.053366363,0.03735243,-0.00940306,-0.040673066,-0.007854238,0.056945696,0.013512298,-0.04390455,-0.04529836,0.06605527,0.017971586,0.004539589,-0.063766345,0.04633696,0.013911155,-0.036315672,-0.0027821942,-0.005819721,0.011013075,-0.08382711,0.015601402,-0.0076863654,-0.06326802,-0.0228594,-0.044349823,0.057489764,-0.011126975,0.05396448,-0.084599175,0.005771868,-0.06777077,-0.06187799,0.02507389,0.024212655,0.083597094,0.07692856,0.024304776,-0.018315643,-0.02041723,0.034835592,0.0024538045,-0.04488107,0.06288741,-0.057756253,0.030292058,0.0150629915,-0.021932816,0.009184725,0.059900094,-0.031072194,-0.016444305,-0.008138885,0.0138649475,0.04360082,-0.0317694,-0.08049511,0.010551747,0.12523392,-0.0262919,0.06001638,0.09434358,-0.03153108,-0.06335132,0.032763317,-0.01664521,0.018115142,0.03461946,-0.041048884,0.028434666,-0.048219334,0.04362954,-0.050272558,0.03900553,0.012263892,0.10358064,0.037933722,0.004031995,-0.03937753,-0.15679859,4.2584087e-33,0.05857084,-0.015972601,0.0144067705,0.02644015,-0.039200317,-0.009661893,-0.059342176,0.028953247,-0.00078578934,-0.048466124,-0.0042297808,-0.015390002,0.016050871,0.043210343,-0.008990609,-0.030879132,-0.0074769175,-0.019069642,0.052683905,-0.028101705,-0.064536035,0.057432313,-0.042586867,0.010085475,0.058833133,0.0073202164,-0.008413085,0.044022046,0.012727067,-0.0001292528,-0.11240183,-0.017219877,-0.15744255,0.061205033,-0.031711027,0.01616728,0.0026194677,-0.073897876,0.02082906,0.07442003,0.038150303,-0.013611252,-0.020205574,-0.14168082,0.11342972,-0.06039457,-0.041512553,0.068446,-0.073399775,-0.027533349,0.048035916,-0.00051336404,0.045723904,-0.019710932,-0.10743975,0.0019195777,0.017143488,0.038729183,0.062992096,0.08937015,0.058343977,0.009013491,-0.05541212,0.0085320305,-0.05350508,0.02460347,-0.06628915,0.0032686922,-0.023049237,0.0885794,-0.05718244,-0.012632962,0.11596566,0.0039402847,0.045918293,-0.09829461,-0.07407106,0.085410275,0.028112872,0.07231096,-0.015810668,0.025868062,0.023545064,0.010052492,-0.040813528,0.00078568957,0.06744359,-0.046336837,-0.07821617,0.022711748,0.02745928,-0.05928669,0.026436664,0.026946997,-0.026318785,-6.2108875e-33,0.05881734,-0.09571282,0.09864191,-0.058401443,-0.010216564,0.033503737,0.08696811,0.02973375,0.009493176,-0.11546277,0.11032944,-0.027433906,0.005752403,-0.07641037,0.06388536,0.0045662387,-0.023845015,0.05912824,0.03453622,-0.0072238157,0.0060374294,-0.024258142,-0.036833614,0.022647114,0.03315099,0.0052205794,-0.056171384,0.06780768,0.04855391,0.036158185,-0.10775928,0.09229356,-0.071984105,-0.031428117,-0.04143993,0.00045722513,-0.11654215,-0.010117061,-0.015288728,-0.018733975,0.020687807,0.015404372,0.03868109,0.029882617,0.07266313,0.10099366,-0.046584327,-0.034406114,-0.029988166,0.01028031,-0.0023952585,-0.035367116,-0.050064985,0.047558747,-0.026749652,0.040449116,0.04656847,0.014740004,0.03376835,0.019524394,-0.024112137,0.044879906,-0.015657285,0.078874275,-0.01037387,0.011275342,-0.059612524,0.01834747,0.03927477,0.023303954,0.08190106,-0.06054593,0.08798462,0.02433078,0.025381492,0.037913974,-0.049899515,-0.03322102,-0.004665992,-0.061133653,-0.0011091221,0.0057114772,-0.053714875,-0.012318894,0.024036493,-0.004403091,0.015135075,0.05175404,-0.0059961197,0.04392343,-0.01739102,-0.03240553,-0.009641247,0.06824983,0.062719874,-4.4830816e-08,0.03918113,-0.072818495,-0.0014622358,-0.05854152,-0.04117694,-0.016296273,-0.04553801,0.047428973,-0.06543734,-0.033386093,0.0016320253,-0.029581167,-0.015475585,0.03749439,-0.043517265,0.081245564,-0.031086307,0.013745218,0.011910259,0.00805264,-0.091717705,0.03530258,-0.06349095,0.03806852,-0.052770693,-0.020928085,-0.011312761,0.0827114,-0.009438513,-0.027743557,0.00058374833,0.046396084,-0.01139312,-0.044276115,0.07210453,0.017873755,-0.002656034,-0.04935294,-0.007531131,-0.020668847,0.045593884,-0.061722934,-0.057724357,-0.028933862,0.10752123,-0.0057490333,0.0009079482,0.031304214,-0.014343958,-0.018750252,0.01755163,-0.0003563676,-0.06359108,-0.093061425,-0.0148632135,0.031206395,-0.04093223,-0.091714025,0.026823996,-0.12675951,0.037896108,-0.024054928,0.18410875,-0.0023479778 +3.4.21.1,"Chymotrypsin A is formed from cattle and pig chymotrypsinogen A, several iso-forms being produced according to the number of bonds hydrolysed in the precursor. Chymotrypsin B (formerly listed as EC 3.4.4.6), formed from chymotrypsinogen B, is homologous with chymotrypsin A. Enzymes with specificity similar to that of chymotrypsins A and B have been isolated from many species. In peptidase family S1 (trypsin family)",384,1.0,-0.02588802,-0.0047745546,-0.10233785,-0.02693219,0.041196518,0.08344914,-0.031564575,0.048758406,0.019798683,-0.010740773,0.059175763,-0.08375615,-0.0010021721,0.08082911,-0.024838101,0.03353891,-0.09555761,-0.070296705,0.013518606,-0.03815,0.006274589,-0.02448863,-0.052538875,0.03288782,-0.005553676,-0.056961007,0.04243804,-0.010018079,0.02041992,-0.019364364,-0.05171004,-0.031188434,0.004510545,-0.076156996,0.09168324,0.014383952,0.07732093,0.022600746,0.09476897,0.019981837,0.0034423626,-0.02398542,-0.022793133,-0.020145431,-0.014774197,0.01642282,0.022666857,0.09835452,0.00037588965,-0.0055428525,-0.004406128,-0.03421061,-0.017152123,0.02201349,-0.0055126925,0.0078019304,-0.095044024,0.05113092,-0.0024319652,-0.026283963,-0.0024414898,0.03730075,0.055661194,0.014394358,-0.014432629,0.0100863455,0.036757242,-0.035337348,0.019504117,0.004040635,-0.07204832,-0.04934568,-0.046742775,0.08213462,-0.02665967,0.06559921,-0.032867577,-0.03584277,-0.05215382,-0.05918287,-0.045662757,-0.00977838,0.021499688,0.06454028,-0.037370343,-0.048739977,0.027141059,0.022107568,-0.06484374,-0.06302107,0.018240035,-0.10496805,0.08480525,-0.03184606,0.023691347,0.04490479,-0.06799019,-0.013822031,0.04323217,-0.054108497,-0.011918195,-0.03738562,0.02062047,-0.040277977,0.02658119,0.07746343,-0.15623553,0.06749772,0.11257943,-0.0021551817,0.008253254,0.005647047,-0.000977513,0.002851911,0.09136744,0.08679364,-0.007718151,-0.04022261,-0.016486129,0.041837238,0.10767947,0.017380023,0.038818683,0.0542638,0.0343044,0.02082479,-0.0346907,4.2776335e-33,0.040988993,-0.056670718,0.008686586,-0.007832747,-0.055987973,0.009309521,-0.06925072,0.021379177,-0.020745883,0.013648271,-0.10846586,-0.070494555,0.016159145,-0.017754748,-0.05288387,0.0063887984,-0.039176106,0.0059860386,0.050007228,0.044840444,-0.09450046,0.15894233,-0.009426464,-0.034626834,0.07459328,0.05518588,0.013271841,-0.015417333,0.048867457,-0.027320523,-0.013214201,-0.037866566,-0.14324503,0.025066866,-0.036962453,0.014845948,0.07611686,-0.05768791,-0.003955383,-0.0015067497,0.10203075,-0.01879529,0.024311287,-0.056257367,0.12668964,0.0022029164,-0.123900734,-0.048279945,0.025969118,-0.015217499,0.035039797,-0.013741424,0.084757686,0.051529523,-0.04118429,-0.030438788,0.009657546,-0.0008133574,0.012525572,0.02989404,0.047577217,0.047588605,-0.045247424,0.00536498,-0.046841323,-0.029646264,-0.044286832,-0.025317498,-0.06589587,0.026525903,-0.015836239,0.013993297,0.07005753,-0.05412007,0.09207243,-0.076562725,-0.052789986,0.07854625,-0.01951375,0.05854553,-0.026091125,0.0011975792,-0.028019926,-0.06053619,-0.110002205,0.0015224393,0.0075504025,-0.002828419,0.02460887,-0.009832726,-0.013830105,0.011237608,-0.07942773,0.061921146,0.011883656,-5.997452e-33,0.00093861384,-0.06501054,0.095806025,-0.031526007,-0.04493536,0.056541175,0.04505403,-0.02763782,-0.008012225,-0.04875947,0.011883413,-0.060928386,-0.015870603,-0.07026615,0.034763947,0.00065810006,0.010317393,0.07534733,0.02350377,0.016506609,-0.092876814,0.023831567,-0.021957729,0.074206956,0.120593645,0.030825358,-0.033684883,0.035623673,0.057166506,0.008677694,-0.051080234,0.004655963,-0.055086583,-0.06493835,-0.059102535,-0.044622548,-0.109119095,0.031076876,0.023157373,-0.071199834,-0.0042900806,0.08337185,0.033356197,0.07386386,0.046008572,0.121280804,-0.0075857025,0.009658768,0.028226184,-0.01621686,-0.035946436,-0.002447723,0.036458828,-0.015393191,0.019292915,0.06407913,-0.023310397,0.07308835,0.03481288,-0.0036860434,0.0004667531,-0.01139253,-0.001281104,0.050910357,0.043415487,0.0055484143,-0.13045447,-0.050819714,0.08444216,0.0069936835,0.029437961,0.030283438,0.059556957,0.068512626,0.065837555,0.04752335,-0.049143165,-0.09306159,0.011783716,-0.069874644,-0.050116755,-0.007998362,0.050623983,0.041929644,-0.034414947,-0.0949711,0.014012623,0.066374674,0.097603574,-0.004743056,0.016618542,0.016119681,-0.023003604,0.027522637,0.04728886,-4.261948e-08,0.09117319,-0.08627679,0.004243357,-0.10172906,-0.006757953,-0.016836222,-0.036347255,-0.026564011,0.07996073,-0.07067088,-0.05869052,0.010055732,-0.02864146,0.0045311684,-0.018386746,0.006798913,0.014917653,-0.019390633,0.02555052,0.007273066,-0.095152035,-0.02642775,-0.05161497,0.043357782,-0.010786924,-0.014979845,-0.035762675,0.054781515,0.0411091,0.0098093245,-0.0409813,0.011052277,-0.050974995,-0.013428571,0.07282212,0.031005267,-0.035327062,0.031587575,0.058847234,0.021260275,-0.00024185138,-0.0825988,-0.03698774,-0.03600825,-0.010103355,-0.10042811,0.0010671822,-0.0064061964,-0.02349114,-0.060013354,-0.011091986,-0.04635811,-0.035888307,-0.09186659,-0.057103533,0.012521505,-0.031343702,-0.073287286,0.025058726,-0.03719305,-0.039163753,0.035823938,0.16014196,0.07185687 +3.4.21.2,"Formed from pig chymotrypsinogen C, and from cattle subunit II of procarboxypeptidase A. Reacts more readily with Tos-Leu-CH2Cl than Tos-Phe-CH2Cl in contrast to chymotrypsin. In peptidase family S1 (trypsin family)",384,1.0,-0.005231328,-0.007206997,-0.074351065,-0.0017875312,0.10973324,0.08873514,-0.0049663866,0.10415081,0.04238679,0.03713188,0.058857396,-0.068616934,-0.0072636656,0.07465366,-0.05797426,0.0051255645,-0.035596494,-0.035263147,0.017137108,-0.04243061,0.02131124,-0.044086356,-0.021238744,0.040941022,-0.0390004,-0.075486355,0.04842918,0.019288085,-0.027411394,-0.030332703,-0.049446817,-0.04980557,-0.029369712,-0.063358635,0.052325785,0.0023686185,0.064225666,0.01398692,0.11143086,-0.013693177,0.014576585,-0.025499783,-0.063223936,0.0059604133,-0.023984985,0.06429474,0.060160033,0.10473496,0.02225887,0.021549243,0.02786525,-0.03135071,-0.019546794,-0.013859372,-0.0388504,0.015800469,-0.04392467,0.068072684,0.04084502,-0.046335027,-0.027478566,0.037888758,0.060831297,0.051077936,0.024219923,-0.021140138,0.03673187,0.01443349,-0.029046616,0.0049730088,-0.019609163,-0.033615343,-0.04897741,0.08187729,0.034118738,0.06308915,-0.024389055,-0.049443807,-0.026601046,-0.08763837,-0.011800246,-0.01572051,0.023835856,0.052054152,0.0059698173,-0.053896196,0.022282552,0.047603644,-0.028578447,-0.09455737,0.02258724,-0.1355484,0.046774197,0.025909582,-0.004323818,0.006889862,-0.06320914,-0.03930362,0.0023207273,-0.019723542,-0.02191187,-0.02167188,0.033725083,-0.11554772,0.0034808593,0.08367305,-0.12076088,0.058860146,0.0780921,0.059615593,-0.0014220333,-0.0051727886,0.00071731844,-0.011312648,0.05497885,0.083671734,-0.04971521,-0.03670621,-0.055914115,0.029453767,0.10502395,0.0095195435,0.007409305,0.0966903,0.0038296916,0.034917075,-0.026434038,4.8938387e-33,0.011699868,-0.062491238,0.014273874,0.004416375,0.03327885,-0.0007078675,-0.012604344,0.014014561,0.011730228,0.01844593,-0.12235594,-0.1290872,0.021451384,-0.036352284,-0.07105785,-0.007273126,-0.0860682,-0.040079765,-0.011798012,0.030053977,-0.09983341,0.1194822,0.009469699,-0.036023006,0.10008711,0.0429638,0.0018365541,-0.016754683,0.053496405,-0.022284264,0.010238218,-0.089403585,-0.13095854,0.03454724,-0.002789388,-0.019307798,0.10457281,-0.12035573,0.023619598,0.014576387,0.06437216,-0.04651931,0.025158862,-0.04981066,0.11896697,-0.040885787,-0.0793334,0.00015237005,-0.026334269,0.025207916,0.034058515,-0.044164095,0.077098854,0.03479823,-0.06242952,-0.048868116,-0.016933031,0.001912993,0.050181422,0.037633725,0.055293262,0.050752413,-0.03326059,-0.016737454,-0.022167552,-0.016227521,-0.09564517,-0.027235093,-0.057324376,0.026589107,-0.024179662,0.0072964984,0.05833317,-0.060690068,0.009738569,-0.047828294,-0.04683172,0.10362995,-0.019564511,0.05206066,-0.014241676,0.024824627,-0.07350767,-0.020090098,-0.06306464,-0.008317361,0.019276598,-0.073131524,-0.043511033,-0.020844396,0.03654252,0.014449449,-0.051527426,0.040261142,0.003667132,-5.6383303e-33,-0.018842677,-0.039550062,0.11623615,-0.0013164046,-0.019830758,0.022719273,0.01740621,-0.038875613,-0.014008448,-0.08389779,0.0056843483,-0.0821391,-0.0076213335,-0.0514765,0.036719106,-0.008875634,-0.012497922,0.0990508,0.02216632,-0.04350163,-0.034921065,0.02388421,0.0059023164,0.071464345,0.11535393,0.010927014,-0.030258257,0.06992697,0.07857377,0.02066679,-0.01583559,0.023082664,-0.06263369,-0.037334695,-0.039927304,-0.025045231,-0.07987725,0.030804222,0.0007385327,0.002318123,-0.023479583,0.037361458,0.014888425,0.040586416,0.017328966,0.100236155,-0.012495107,-0.011308662,0.06206089,-0.053059325,0.0034744716,-0.041181725,0.009918944,-0.008885399,0.04029449,0.071960606,-0.0036408748,0.044081155,0.055374764,-0.041038573,-0.022216814,-0.014007497,0.012675172,0.03805845,0.05288311,-0.01331265,-0.119038865,-0.04145149,0.13355243,0.016024388,0.04868878,0.010929471,0.03231362,0.0395173,0.027442237,0.04074059,-0.041843023,-0.052475672,0.053818315,-0.07142012,-0.06311659,-0.07260546,0.043820217,0.04293166,-0.0017383801,-0.05919895,-0.037394445,0.09506385,0.090650685,-0.0029225983,0.004066383,0.024840375,0.06257543,0.05907947,0.059112526,-3.587247e-08,0.084541075,-0.07376792,0.016671086,-0.06273628,0.018253222,-0.030353824,-0.046557512,-0.032082014,0.022340272,-0.07118604,-0.029786278,-0.0005877321,-0.052448973,-0.011759684,0.05699184,0.052808754,0.009341574,0.054447573,0.0058779423,0.055265196,-0.07760228,-0.02300441,-0.08957727,0.0029679488,-0.021362348,-0.020601487,0.0045055654,0.08390178,0.023395194,0.0017032863,-0.042553704,-0.02573109,-0.061058972,-0.06605538,0.061534703,0.043697674,-0.07332205,0.042645037,0.03900898,-0.011455304,0.009858119,-0.048757,0.0036650207,-0.03924665,-0.004220433,-0.07578723,0.04535486,0.035534363,-0.048582394,-0.074804515,-0.040709954,-0.05391607,-0.053510476,-0.05222195,-0.028874146,0.00398171,-0.021904135,-0.06935309,0.026659386,-0.04302628,-0.019901788,0.092928566,0.13948922,0.05412387 +3.4.21.3,Digestive enzyme from the sea anemone Metridium senile.,384,0.99999994,-0.057847302,-0.0543014,-0.0420766,0.01902775,-0.03451478,-0.043511547,0.022180565,0.007853164,0.049760465,-0.039866067,0.05413991,-0.10933924,-0.0779679,0.0428593,-0.049741093,0.010265242,-0.016686976,-0.033243712,0.031383336,-0.07759473,0.07055076,0.11843642,0.020567723,-0.047097158,-0.073299274,-0.040410083,0.05155701,-0.05063472,-0.061821725,-0.059935033,0.029169569,-0.06448176,0.098050326,-0.012738314,0.08153829,0.08576488,-0.030702552,-0.03881702,0.040778115,0.038688723,-0.0042325733,-0.004901041,0.005318569,-0.016203221,-0.048266076,-0.029259453,-0.03348717,-0.0100154625,0.04699191,0.0032112831,-0.13588859,-0.120812505,-0.030005634,-0.05552057,-0.021767661,0.020085597,-0.029124437,-0.027957082,-0.029717362,-0.06555582,0.032558918,0.017999962,0.03189787,0.019878265,-0.005449604,-0.04015842,0.07556095,-0.042010445,0.026066966,-0.060755525,-0.0443308,-0.09655823,0.046044122,-0.028839728,-0.043112848,-0.016349863,0.010472788,-0.09796846,0.009391975,-0.06397804,-0.031009685,-0.022735223,-0.03786751,0.044445828,0.0983002,0.021978164,0.0074546584,0.003431307,0.048183057,0.00090609456,0.0009854113,-0.036600277,-0.03558617,-0.09231476,-0.010149884,0.042829584,-0.043423466,0.038081672,-0.01641235,-0.016735652,0.02008714,0.050412226,-0.030770194,-0.113055594,-0.018340828,-0.028220307,0.03762712,0.011843236,0.054267343,-0.020636402,-0.03577961,0.026989762,0.05326405,0.0009275864,0.0048220116,0.09264017,-0.003988898,-0.051548384,-0.030740693,0.060084578,0.011149347,-0.069206685,0.040832166,0.020111647,0.0028009235,0.079591095,-0.01440403,-9.869764e-34,0.025333606,0.014759105,-0.06137477,-0.038292617,-0.008571949,-0.050637074,-0.04310891,0.037781786,-0.047567617,-0.024124982,-0.08318589,-0.07198836,-0.060784806,0.007970939,-0.018508248,-0.0012949149,-0.014356696,-0.034705218,-0.016621204,-0.0119512845,0.018847097,0.021882806,0.028310051,-0.014980737,0.027841251,0.0052656564,-0.044092048,0.023934115,0.063812144,0.009875414,-0.008964728,-0.13936885,-0.068006545,0.07664899,0.0825508,0.039162677,-0.049855504,-0.0016029124,-0.07272034,0.03227994,0.05581859,-0.0037151587,0.02466508,0.018737428,0.052905913,-0.0071198894,-0.05954446,0.08858452,0.14168212,0.0108643565,0.0842801,-0.03123581,0.09795957,-0.037061997,-0.09540547,0.04684355,0.03361499,0.07460378,0.058996253,0.027707553,-0.066717096,0.0667572,-0.0010632561,0.06106356,0.024103513,0.072295755,-0.009716558,-0.0012769107,0.06767702,0.009193886,-0.080277905,0.0017387933,0.030904232,0.039877456,-0.008230049,-0.027779147,0.024978183,-0.036508173,0.019666348,-0.008685458,-0.02974975,-0.0126276035,0.036662813,0.09247007,-0.031328846,0.04605688,-0.025637828,0.05220298,0.080641165,0.006417307,0.028228601,-0.02294988,-0.06733328,-0.099945135,0.039013356,-2.923966e-34,0.041133605,-0.016930006,0.0004647726,-0.014136586,-0.058781706,0.02356137,0.014139256,0.048535787,0.019756503,-0.041462637,0.0050804825,-0.013137556,0.06999609,-0.11763473,0.049580783,0.118706174,0.07314051,0.113735914,0.0138088325,-0.038469993,-0.01880017,0.05133644,0.06586516,-0.020484604,-0.025813086,0.08259792,0.07271094,0.009483083,-0.016693734,0.0073797484,0.048576508,0.103446916,-0.008719418,-0.07960959,-0.06975166,0.018141476,-0.10627017,-0.049728952,-0.008928729,0.039522287,0.030486146,0.036613055,0.06312694,0.043148514,-0.00054435927,0.0402154,-0.020920042,0.0023888466,-0.0913247,-0.06517599,0.026858738,-0.011357702,0.051515594,-0.13044156,0.079459004,0.08511871,0.0028509563,-0.03142337,-0.009520836,-0.07900613,-0.027491264,-0.045335457,0.0979707,0.024467207,0.047870997,0.05165716,0.01773471,0.033765327,-0.038314834,0.010024094,0.07053114,0.022720894,-0.058507074,0.009875889,-0.0033689968,-0.0023891556,-0.1208636,0.04830875,0.07215988,-0.0081676915,-0.012129727,0.06717301,0.025403574,-0.09457456,0.015945494,-0.06958263,-0.06811251,0.030964145,0.046980936,-0.011870084,-0.032717407,-0.021306733,-0.058390483,-0.010996248,0.07178387,-1.873285e-08,0.105258316,-0.043432906,0.07009287,0.011116696,0.04821825,-0.049228195,-0.0063235536,0.0511203,0.021323243,0.0049985065,-0.010445348,0.037140235,-0.021095578,0.00576266,-0.05599517,0.05527998,-0.029739358,0.017592458,-0.06066892,0.011295279,-0.009576709,0.044522576,-0.08763231,0.03631289,0.026695987,0.01748577,0.014149013,0.050751187,0.0049432917,-0.07846091,0.014528802,0.01581432,-0.0243188,-0.046890143,-0.038843043,0.00216954,-0.014266757,-0.04541999,-0.066950224,0.063209094,-0.010662537,-0.022381755,0.020733109,0.019624416,-0.066988975,0.03602116,-0.053626526,0.05828088,0.023660399,0.034778442,-0.008244454,-0.008453373,0.024403626,-0.036376003,-0.07926487,-0.07049303,0.058707494,-0.058903318,-0.07651752,-0.08709865,0.08095523,0.05679159,0.15019141,0.027403114 +3.4.21.4,"The single polypeptide chain cattle beta-trypsin is formed from trypsinogen by cleavage of one peptide bond. Further peptide bond cleavages produce alpha and other iso-forms. Isolated as multiple cationic and anionic trypsins [5] from the pancreas of many vertebrates and from lower species including crayfish, insects (cocoonase) and microorganisms (Streptomyces griseus) [3]. Type example of peptidase family S1.",384,1.0,-0.012136454,-0.06467302,-0.09073744,-0.028767569,0.015726898,0.06537496,0.040224977,0.046158686,0.05798764,0.03967576,0.06793595,-0.046262797,-0.06609948,0.12248993,-0.06564429,-0.023448698,-0.046341218,-0.041403275,0.13356933,-0.05701031,0.021637965,0.045409717,-0.015673729,0.04816314,-0.06983719,-0.050851714,0.009322004,-0.027434025,-0.008791484,-0.019830791,-0.06927682,-0.07967574,0.030999478,-0.025097374,0.046007928,0.028016375,0.04042226,0.016680075,0.061017692,-0.00032710566,0.036019273,0.0092409095,0.026054421,-0.015458489,0.027898742,-0.0034835557,-0.029005405,0.07190015,0.11333365,-0.039903324,-0.013921539,-0.08275483,0.014990596,0.013077558,0.056497682,0.022014976,-0.041809503,-0.0065423725,0.021741265,-0.00012486782,-0.011750505,0.019174147,0.07055266,-0.006307218,0.008514432,0.013187513,-0.028904518,-0.028325234,-0.023891931,-0.0020439874,-0.037753973,-0.04472876,-0.064865984,0.06926295,-0.040961422,0.113793045,-0.020667376,-0.010948489,-0.04360671,-0.031557348,-0.038739424,-0.018025346,0.047892474,0.07906016,-0.007335237,-0.0037131035,0.026432883,0.06154104,-0.0101202885,-0.066608414,0.026331974,-0.063757956,0.043221056,-0.04670132,0.020964215,-0.04245184,-0.08151025,-0.11548285,0.055511557,-0.008366242,-0.01005256,-0.036028784,0.028972983,-0.103432946,-0.009664795,0.0831816,-0.101782374,0.049941693,0.13761199,-0.0011425216,-0.053749025,0.054962598,0.0676955,0.009456791,0.04046105,0.04035933,-0.033955265,-0.031195894,-0.0019097113,0.009977052,0.035467528,0.004039987,0.013739693,0.08218283,0.01652676,0.01867153,-0.045570947,4.4257307e-33,0.05725986,-0.046057288,0.05833195,0.061055407,-0.032206252,0.0014584104,-0.020565758,-0.013788181,-0.012042776,-0.009447142,-0.110713825,-0.1164702,0.013901246,0.03864888,-0.0034286024,0.031360637,-0.033002708,-0.015088617,0.098753385,0.024149712,-0.105713256,0.12432382,0.070104346,-0.12173167,0.11098578,0.02867699,-0.040503886,-0.010622299,0.028588677,-0.051904164,-0.0063724183,-0.03931122,-0.112706155,0.09043715,-0.009019742,0.018528072,0.0800887,-0.062110957,0.005645425,0.038606852,0.075997576,0.0101986015,0.008198387,-0.021990368,0.13774088,0.0042019086,-0.033071313,-0.016870318,0.044601176,0.017292656,0.02806788,0.011127681,0.047982987,0.011225447,-0.10705807,-0.009963492,-0.0132809,-0.013069924,0.05152384,0.038880058,-0.003141123,0.031457372,-0.05393491,-0.021524156,-0.014199085,0.013097705,-0.022213344,-0.056184735,-0.032648794,0.019727768,-0.020728841,0.011430465,0.05154194,-0.09712971,0.025714112,-0.05809165,-0.03900798,0.03079979,0.013675636,0.0513259,-0.039492268,-0.0018934944,-0.02202514,0.016749814,-0.07331122,0.03919407,0.065934084,-0.01913401,0.035044614,0.0057148566,-0.02506797,0.0116586285,-0.064507425,0.026396476,0.055171195,-4.3908005e-33,-0.018380841,-0.10444111,0.069923684,-0.051019132,-0.061775815,0.009261538,0.0048333015,-0.029171128,0.0060827606,-0.060035642,0.024034727,-0.059413925,0.027900456,-0.086878486,0.023243869,-0.01779104,-0.022639256,0.0879288,0.008909141,-0.070843324,-0.062299434,0.008961435,0.0367541,0.045853056,0.10624238,0.0711952,-0.013963772,0.10345106,0.04500531,-0.045290217,-0.005515263,0.046183195,-0.05485748,-0.06252161,0.0039043217,0.0031095566,-0.11077815,0.039063074,0.0755199,-0.038792502,0.02170398,0.069673695,0.041204065,0.03235709,-0.008080637,0.098183945,-0.003689289,0.009245186,0.021856856,-0.050922066,-0.036774117,-0.057356752,-0.012959582,-0.04928921,0.0656585,-0.014223787,-0.0113724675,0.044342287,0.026686195,-0.02012932,0.0063653234,-0.0020098663,0.017151203,0.00916383,0.06537091,-0.004114032,-0.03316282,-0.04992272,0.025310634,0.015739368,0.04350835,-0.025828583,0.070428245,0.07490144,0.031463094,0.020136727,-0.05258736,-0.079443514,0.04634747,-0.049855955,-0.022965007,-0.049684737,-0.014068133,0.04802644,0.008560422,-0.05346657,-0.00184758,0.06866552,0.08795862,0.0045141163,-0.0040213424,0.04268634,0.06848743,0.022269256,0.06178169,-4.02701e-08,0.11894337,-0.066112235,0.014906317,-0.08869012,-0.060562514,-0.0151391495,-0.014129446,-0.016898323,0.027556539,-0.09476405,-0.042251628,-0.0025754531,-0.012980019,0.00093007536,0.0026684431,0.015964033,-0.04314483,-0.015393293,0.0049801013,-0.0005441795,-0.15746869,0.00050111354,-0.08007826,-0.030847222,-0.055777863,-0.06954922,0.01753407,0.056366827,0.014630551,-0.025054336,-0.03295279,0.009349931,-0.03422681,-0.021361379,0.10181389,0.10065662,-0.052284658,0.03649454,0.089242354,-0.027940163,-0.038308512,-0.06184313,-0.006843294,-0.04276146,-0.07484224,-0.06210183,0.0038561586,0.02789386,-0.00265716,-0.05810908,0.02180204,-0.007844401,-0.034896187,-0.06865054,-0.06424406,-0.040834323,-0.0043667937,-0.05762841,0.057624165,-0.026647624,-0.024810897,-0.036130156,0.13218947,0.05578195 +3.4.21.5,Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family).,384,1.0,-0.06334491,-0.04527082,-0.104858115,-0.03846075,0.08092595,0.06790031,0.039651997,0.12460767,0.06254101,0.06043693,0.07202694,-0.011329582,-0.0072024777,0.05779702,-0.044554453,-0.022166265,-0.0061724475,-0.07953147,0.0034935635,-0.084367946,0.052257072,0.011386939,-0.0020964814,0.02559161,-0.033627268,0.026319776,-0.010942043,0.035751887,0.109685645,0.006390992,-0.08225766,-0.026859801,0.0014534867,-0.0337145,0.014308606,0.035847247,0.0385776,0.009699548,0.004125774,0.0023007214,0.05807008,0.019481592,-0.07283977,-0.04017505,0.0053842706,0.007345112,0.0153913135,0.12676816,0.029200548,0.053716745,0.016243024,-0.05271559,-0.04559104,-0.008794349,0.04937062,0.021393688,-0.101369664,-0.05876923,0.03552362,0.035851743,-0.100467905,-0.023620475,0.029549772,0.010676989,0.056461122,-0.020402657,0.031148748,-0.02641589,-0.012166313,0.008816005,0.04582992,0.011513419,-0.058866467,0.119230926,-0.015675167,0.014374962,0.0038417869,-0.058628988,-0.045639727,-0.032402474,-0.04428199,0.04843388,0.028212223,0.1393155,-0.010782467,-0.017592756,-0.019105567,0.023927227,0.004278811,-0.07227516,0.034278456,-0.058613323,0.057854485,-0.02124796,0.02877269,0.04394826,-0.07020791,-0.037441995,0.020278445,-0.039878536,0.0034403435,-0.042019293,0.043769065,-0.107754454,-0.05252937,0.025366586,-0.06844028,0.050332315,0.04144836,0.0350546,0.025348239,-0.01978251,0.07674381,-0.040897653,-0.0287425,0.02456592,0.0037661407,0.0018054922,-0.033373874,0.0657598,0.019464223,0.044588603,-0.011800696,0.075317495,0.015269626,0.030467896,-0.07025337,2.5135476e-33,0.018646616,-0.062123816,0.042354472,0.040766664,0.013081179,0.037531216,-0.0005492302,-0.012635908,0.022963038,0.009541845,-0.08203279,-0.072078735,-0.0059090187,-0.0053581586,-0.040605742,-0.007929747,-0.05383207,-0.043981403,0.028258283,0.041388236,-0.06593271,0.12956801,0.06242046,-0.10501962,0.023833038,0.023039889,-0.03617289,0.012537049,0.041721534,-0.022825807,-0.014101265,-0.037137583,-0.09583388,-0.018647859,-0.008955319,0.009313573,0.07716668,-0.057078455,-0.043432098,0.0389189,0.032955114,-0.022155143,-0.09657619,-0.017360922,0.098427005,-0.09658547,-0.062257215,0.021651356,0.0024645827,0.05994044,0.04443896,-0.032762058,0.11605164,0.013064479,-0.105444275,-0.046233296,-0.044942103,0.015098627,0.01442352,0.066893615,0.03369863,0.03535762,-0.034221318,0.039507184,0.03503216,-0.0036344447,-0.03384704,-0.03189679,-0.014169594,0.001909111,-0.009572356,0.03636812,0.0563536,-0.006750012,0.040862143,-0.08866659,-0.012389617,0.12251299,0.035769653,0.02880956,-0.039637897,-0.0050943075,-0.039000407,0.026114533,-0.08573001,-0.02723832,0.03854851,-0.040592726,-0.049992345,-0.064385824,0.018227328,-0.039220754,-0.034305274,0.043554068,-0.03892722,-3.7584118e-33,-0.006391336,-0.10395304,0.08054177,-0.021691056,-0.014351444,0.04440599,0.040996455,-0.025496589,0.04774946,-0.0051407465,0.04851489,-0.0671071,-0.006940834,-0.06552296,-0.01379971,0.012708734,-0.06360739,0.12733616,-0.02205969,-0.04245298,-0.05064202,0.008531767,0.05496096,0.06892666,0.066320874,0.047750387,-0.07027186,0.044597104,-0.0010984638,0.019443039,-0.00989765,-0.02135052,-0.12623176,-0.07041127,-0.043920435,-0.029008422,-0.054212376,0.05932027,0.04215578,-0.09016513,-0.009194863,0.091658555,0.14207104,0.08595427,0.010246309,0.1052807,-0.008900654,0.00025558713,-0.04472214,-0.047064293,-0.042078268,-0.02936368,-0.051445305,0.062130906,0.04290285,-0.04484888,0.006930503,0.048771765,-0.002779577,0.02310741,-0.008700798,-0.06590936,-0.043851018,0.10269221,0.108641595,0.020106222,-0.02883517,-0.015102593,0.08353391,0.0233586,0.050898466,-0.050290443,0.048258327,-0.0020504235,0.03379731,0.062716596,-0.017537437,-0.10182226,0.0062135695,-0.069393344,-0.040287953,-0.07638644,-0.064680405,0.015599924,-0.038094576,0.003771659,0.03708907,0.03091754,0.07909457,0.010317697,-0.03737592,-0.025782607,0.012045017,0.045300018,0.03294941,-2.7369703e-08,0.10148163,-0.061993342,0.00057387503,-0.08847449,-0.027270934,-0.024730604,-0.04937645,0.05210303,0.04549798,-0.059221286,0.02900095,-0.031490557,-0.046859283,-0.05377894,0.07331255,0.026509298,-0.011583915,0.076148845,0.018397108,-0.059384152,-0.039030496,-0.046734646,-0.0065442403,0.022728862,-0.045670155,-0.0467402,-0.025793022,0.03614312,-0.0018064149,-0.02943718,0.007411202,-0.008576389,-0.03588233,-0.029618515,0.029865963,0.058821823,-0.00391498,0.030743387,0.034190003,-0.020822024,-0.0078433715,-0.06862561,-0.009880694,-0.06292534,-0.032802638,-0.033298362,0.05205856,0.069177315,0.0108392015,-0.037403956,-0.017134828,-0.049597006,-0.013338959,-0.083475344,-0.111711696,-0.03710985,-0.0021363802,-0.03920978,0.04116815,-0.041070625,0.0001921519,0.069499746,0.1378862,0.09187066 +3.4.21.6,"A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va.",384,0.99999994,-0.03761998,-0.06733127,-0.050161157,4.289275e-05,0.12100487,0.0414486,0.041486215,0.11559051,-0.02967304,-0.018690169,0.07864317,-0.02252808,-0.020010537,0.04985141,-0.02962629,0.016969759,0.028082957,0.024849629,-0.057930015,-0.059647065,0.06441368,-0.014847934,-0.014423475,0.037568387,0.023267346,-0.0005145125,-0.053355295,-0.09768211,0.076098435,0.03046517,-0.04742159,0.054838214,-0.023523666,-0.048362933,-0.017405719,0.09113758,0.034169447,-0.051350247,-0.10714329,-0.0052170972,0.10747467,-0.03817698,0.0075426283,-0.038926404,-0.013296026,-0.031798895,0.019013625,0.08574555,-0.06488732,0.13652083,0.029721772,-0.042567134,-0.04290718,0.061493028,0.05776999,0.023418477,-0.09205617,-0.08260478,-0.019104622,-0.025923328,-0.08160308,0.087792665,-0.005880433,0.036214657,0.11630569,-0.07007399,0.047577668,-0.05287222,-0.039056547,0.005543751,0.0062220464,0.010657449,-0.038864296,0.051798597,0.04184645,0.0106281,-0.03944378,-0.07079163,-0.03263769,0.0016249655,0.022172276,0.09510419,0.0005850826,0.11050173,-0.031841163,-0.014793927,0.0056578577,-0.021729197,-0.07266412,0.05902172,0.0045164977,0.038044814,0.0829661,-0.0303664,0.007958416,0.03483599,0.055048324,-0.047407407,0.048526917,-0.015505072,-0.038748484,0.033239584,0.020983765,-0.013146509,-0.025625676,-0.09164778,-0.10234276,0.111220874,-0.002398288,0.05355087,0.06029927,-0.09889028,0.12848848,-0.06623149,-0.0070091668,0.029541522,0.024250166,0.030457117,-0.0070477114,-0.017388381,0.061074447,0.030173706,-0.049419716,0.030445376,0.08407131,0.0187275,-0.01930273,3.2055588e-33,0.083047345,0.005580665,0.07969155,0.05898245,-0.06414078,0.02499983,-0.03304076,0.039638374,-0.07387373,0.07432689,-0.001840989,-0.02138316,0.019882064,0.104969524,0.0051758746,-0.08393211,0.005443857,-0.050709948,0.07847622,0.03640104,-0.009797755,0.022037815,-0.036742095,-0.0033662862,-0.027654499,-0.012815664,-0.010079511,0.06855155,-0.024977153,0.005945833,-0.069211416,-0.02583352,-0.005749838,0.0008605924,-0.0149021335,-0.03534031,0.014705241,-0.09645666,0.008184677,0.028574875,0.043864362,-0.014253291,-0.07207528,-0.10283183,0.026179265,-0.09112282,-0.026803914,-0.05677471,-0.021479947,0.022496274,0.035956446,-0.030354181,0.15259632,-0.0008787313,-0.0019060923,0.0613938,-0.028284295,0.04400334,-0.035838455,0.04957419,-0.047773622,0.05413385,-0.079437114,0.07944904,0.02251216,-0.04116993,-0.0106695015,-0.14597082,-0.04636569,-0.05623062,-0.040935982,0.024125107,0.04111486,0.03139468,0.039723802,-0.048452783,-0.07625396,0.082149655,0.0093328515,-0.01962863,-0.060078647,0.063607134,-0.02026577,0.0044012857,-0.07704738,-0.05316563,0.034246624,-0.014206799,-0.059870444,-0.09596038,0.009461076,-0.11987615,0.027449483,0.010441921,-0.009329846,-3.8857376e-33,0.00042877693,-0.08240143,0.069594406,0.03655773,0.054359354,0.02554599,0.019389998,-0.0108841425,0.044527825,0.044071805,0.06781773,0.053087577,-0.07262935,0.008133355,0.037306327,0.08315205,-0.0032237014,0.0119415,-0.05492328,-0.048011012,-0.020298524,0.028637357,0.07654645,0.021512339,0.07347667,-0.009098305,-0.0055333404,0.04044913,-0.04317513,0.053616296,-0.1036277,-0.033463825,-0.051336326,-0.051215574,-0.096381344,-0.025172312,-0.015672116,0.07059071,0.0035704912,-0.049351618,-0.016475076,0.044523023,0.106591284,-0.014786189,0.038824044,0.07323002,0.02175077,-0.0014181745,0.054174062,0.019858321,-0.056916326,0.02995921,0.00411291,0.098376624,-0.009066869,0.020934734,0.034323595,0.039885163,0.040358514,-0.012004384,0.030262623,-0.0372983,0.026544083,-0.0011466269,0.05779998,-0.03332229,-0.014316037,-0.012514896,0.023127558,-0.02263907,0.08007867,-0.03190973,0.020899074,0.011216029,-0.011915006,-0.053151853,-0.037069295,0.023217369,-0.028749458,-0.02773616,0.06017751,-0.06600823,0.025575493,-0.010520685,0.03130689,0.015984096,0.0031938467,0.058374416,0.047917776,-0.043735657,-0.09640109,-0.05630588,-0.065539464,0.031999584,0.042883467,-4.3164935e-08,0.011221056,-0.07652483,-0.07006241,-0.086914614,0.02191613,-0.01687557,0.014646676,-0.0022720357,0.064127214,0.024245234,0.024665115,-0.019875271,-0.02827168,-0.030637333,0.044205967,0.03596533,0.025921782,0.03552786,-0.049204186,-0.07407937,-0.019002996,-0.058034714,-0.029560603,0.045287833,-0.043176584,-0.08121413,0.05490151,0.044944867,0.025744231,-0.013434881,-0.038423046,0.037614603,-0.04393231,-0.0043114964,-0.07285814,0.015578345,-0.0014080218,-0.013053022,0.02627523,0.016672961,0.0033351064,-0.03193914,-0.044678975,-0.022092506,0.01007978,-0.005735606,0.06055501,0.0048743486,-0.022580583,-0.013513556,-0.044436965,-0.003437412,-0.06055601,-0.073448405,-0.045194194,-0.028465109,0.049974836,0.004525334,0.05357279,-0.051771928,0.033948135,0.021436375,0.16950396,-0.0065084337 +3.4.21.7,Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. In peptidase family S1 (trypsin family).,384,1.0,-0.07056906,-0.10259529,-0.082129784,-0.046203446,0.05959762,0.058547672,0.026784673,0.0964057,0.049278624,0.06309993,0.05367894,-0.024673244,0.028779168,0.037628476,-0.05940548,-0.0395984,-0.056297038,-0.05006447,0.03974691,-0.08555176,0.09464246,0.015014724,-0.025259433,-0.0014742365,-0.04654334,0.042682428,0.00035331072,0.053693794,0.08112954,0.025531333,-0.036823064,-0.054726638,-0.017000705,-0.05541979,0.073114246,0.03725273,0.024640081,0.011598603,-0.007662615,-0.023538543,0.065862104,0.00927215,-0.038415447,-0.08237455,0.026601434,-0.023069873,0.0374881,0.1063854,0.049957175,0.01852899,0.040210713,-0.0790635,-0.045046393,0.011484521,0.057183802,0.05060398,-0.069296926,-0.022818953,0.034364264,0.049951244,-0.0729025,0.005878035,0.034853064,-0.030660603,0.028167237,-0.022421826,-0.013109344,-0.018670853,-0.058509983,0.021832323,0.00260225,0.0077353227,-0.0467097,0.08967394,-0.023154067,0.019192984,-0.0035141632,-0.042025138,-0.049926776,-0.027186349,0.005367786,-0.00077752105,0.00628982,0.10744883,-0.05391114,-0.0024480494,0.017849712,-0.015183873,0.06911088,-0.0718335,0.012026303,-0.05353163,0.06092697,-0.020118799,0.006626382,0.042124517,-0.10371713,-0.040270314,0.052868422,-0.04124903,-0.013433974,-0.055823483,0.038000587,-0.12723862,-0.047327183,0.04909563,-0.059842482,0.073907465,0.055575088,0.04746433,0.0093264645,0.0036981425,0.046464875,-0.0016311015,0.009257962,0.02480054,0.0028002956,-0.046072654,-0.07304026,-0.018196246,0.045507424,0.012759449,0.01994293,0.04351214,-0.0018254503,0.025152795,-0.03020322,1.7833836e-33,0.0016927699,-0.045202926,0.053715352,0.052925415,0.018773455,0.028439496,-0.0092206225,0.006432161,0.044849444,0.008773841,-0.10725319,-0.04502257,-0.025814246,-0.034647454,-0.067695916,-0.014836067,-0.01087589,-0.033432968,0.01815306,0.04256276,-0.026473112,0.12894656,0.07256724,-0.076099984,0.056712784,0.03541149,-0.006968613,-0.027703146,0.068919994,-0.04407402,-0.02400185,-0.046609633,-0.11749777,-0.034648277,-0.00058812264,0.018817859,0.089190476,-0.039015926,-0.007293797,0.035656534,0.017806722,-0.005183246,-0.049885396,-0.024709659,0.08225676,-0.052475978,-0.084087536,0.050231967,0.02798705,0.04552775,0.020655144,-0.048193697,0.09032639,0.025031324,-0.1158782,-0.027347468,-0.055713337,0.0029764567,0.04756426,0.030204156,0.07126251,0.004593,-0.04293221,0.036356922,-0.012384248,0.0065000113,-0.034501746,-0.022516115,0.00859528,0.021850023,-0.032841813,0.05807664,0.0059922524,0.0071556107,0.07549318,-0.12014698,-0.02958522,0.10226234,-0.0053922026,0.05208961,-0.010767044,0.008712019,-0.04251174,0.029531278,-0.05275811,-0.026315361,-0.0034190118,-0.002535414,-0.07218988,-0.048792716,0.00046288266,-0.02266118,-0.010401408,0.10399239,-0.061911922,-3.2129177e-33,0.013377439,-0.119149625,0.097423695,-0.043859873,0.013616504,0.03646669,0.019415902,0.026847294,0.040044792,-0.015987473,0.0022375518,-0.07823498,-0.0038671803,-0.07427222,-0.03249659,-0.01612455,-0.045515146,0.11184475,-0.014332394,-0.02582344,-0.077567734,0.047153488,0.06881182,0.06580735,0.042763587,0.031168733,-0.046740502,0.06971179,-0.008766626,0.0320135,0.008232941,-0.032365713,-0.061813615,-0.022890454,-0.059895594,-0.018654332,-0.00015437687,0.02369753,0.03679712,-0.0664496,0.02451112,0.079000175,0.12062286,0.10232744,-0.013851012,0.10307663,-0.056511857,0.02119755,-0.061715122,-0.07337459,-0.024341391,-0.08227602,-0.054807365,0.058635514,0.06458687,-0.031789396,0.0067632673,0.04902493,-0.022315733,0.028498055,-0.015247101,-0.07217576,-0.066160545,0.08724987,0.09063971,0.009573002,-0.033874933,-0.030318758,0.055157136,0.019801458,0.050543416,-0.035563193,-0.030175481,0.00838232,0.042953383,0.062808625,-0.059899133,-0.107081875,0.020406228,-0.0832969,-0.03296134,-0.06676729,-0.029106205,-0.022474239,-0.0409884,-0.028232155,0.09008745,0.058156163,0.06386724,0.03536997,-0.04002166,-0.017378703,0.050214507,0.08879903,0.031942658,-2.9481335e-08,0.052326094,-0.04594251,0.04720866,-0.0741981,-0.05649322,-0.022423241,-0.013159927,0.025111087,0.081967495,-0.10339882,-0.015251836,-0.041307338,-0.0021811316,-0.049099002,0.04309499,0.060478758,-0.020513887,0.10312467,0.0019299154,-0.030334188,-0.027119452,-0.043998547,-0.03639895,0.046197593,-0.026520843,-0.03632533,-0.015943646,0.027515402,-0.0539181,-0.0015923206,-0.021868909,0.00077194924,-0.008925066,-0.023290325,0.017276186,0.06405755,0.022140741,0.030196391,0.043205414,-0.025347719,-0.01410297,-0.07427375,-0.012818284,-0.088666916,-0.032811258,0.0050821938,0.030384902,0.043513585,0.025989251,-0.034248356,0.018859442,-0.043422587,-0.025557011,-0.10674799,-0.10815159,-0.05606287,-0.010096907,-0.02346763,0.059266742,-0.06496254,0.05067375,0.07731596,0.13228728,0.100124836 +3.4.21.9,Is not inhibited by protein inhibitors of trypsin. In peptidase family S1 (trypsin family).,384,1.0,-0.01998726,-0.012278685,-0.082349606,-0.04706294,0.031852633,0.07968984,-0.024409346,0.065453716,0.0368932,0.03388308,0.050252054,0.03205215,0.0151710985,0.117226064,-0.057967443,-0.020709012,0.026944175,-0.020272953,0.06670998,-0.044583626,-0.025251808,0.035482455,0.015416226,0.037714586,-0.08443296,-0.006088368,-0.05247505,0.02673796,0.011507979,0.029560048,-0.062170174,-0.039905246,-0.0023653652,-0.01728526,0.016486194,-0.01072144,-0.003685755,0.030275904,0.0065555386,-0.0211656,0.02707091,-0.015362714,-0.0772305,-0.057065636,0.05154929,-0.013381283,-0.033298716,0.0735701,0.060574997,0.018780606,-0.03603781,-0.043767154,0.012058495,-0.012745503,0.054926362,0.059208542,-0.039319247,0.014360469,0.047645785,0.0043109823,-0.04073616,-0.012171398,0.05287605,-0.0070650773,0.04347417,0.0033629853,-0.041664135,0.020483369,-0.017431865,0.025494028,0.036510807,-0.057477817,-0.049135305,0.114182666,-0.05322265,0.039651055,-0.010316389,-0.038504418,-0.039701372,-0.055155225,0.0013349217,-0.070694454,0.056572635,0.100564115,-0.003906496,-0.008864983,-0.013203348,-0.01707939,0.012824736,-0.054628246,0.08588571,-0.10730385,0.028903991,-0.022133246,0.0075066625,-0.023964975,-0.1381235,-0.05961218,-0.08392398,-0.041340232,0.040851824,-0.044492938,-0.021254353,-0.0792937,-0.008449742,0.054853167,-0.037465993,0.01934861,0.061708964,-0.026209157,-0.022293763,-0.0031251945,0.080012195,0.008771845,0.0015522612,0.01281315,0.065142795,0.011984681,-0.04716269,0.017725823,0.09148034,0.029840205,0.05127922,0.044378515,0.006403389,-0.010423367,-0.025744049,5.5684343e-34,-0.002919068,-0.06603631,0.029979812,0.023094488,-7.0756374e-05,-0.008034151,-0.028619424,0.004045661,0.027486313,-0.050360862,-0.11359562,-0.124058016,0.0072334292,-0.005146233,-0.0149740465,0.057681847,0.007880622,-0.043990698,0.04861549,0.03010109,-0.02179634,0.038507648,0.03771685,-0.08961591,0.052169465,0.03227365,-0.054754186,-0.006605501,0.05031873,-0.036360607,-0.06537472,0.007510239,-0.12905306,0.05847987,-0.026472948,0.003121835,0.093643315,-0.06351963,-0.033089027,0.02393234,-0.0070578456,0.037925676,-0.030890912,-0.036732607,0.09354602,-0.024369454,-0.04588906,0.025803905,-0.010032723,0.04975048,0.09214259,-0.06404356,0.00876871,0.020165538,-0.046515178,-0.022579296,-0.014797444,0.016270315,0.08066493,0.06282323,0.007071765,-0.032178007,-0.04014132,0.014725995,-0.015937615,0.007244271,-0.029981578,-0.043505073,-0.058148425,0.0035817975,-0.04970361,0.06839275,0.12984405,0.03890269,0.0057618115,-0.11720807,0.006541568,0.11813153,0.0176046,0.12438758,0.021324717,-0.09040314,-0.037684556,0.041234672,-0.034070242,-0.03386352,0.029673036,-0.03292887,-0.031177785,-0.05579388,0.065231234,-0.0020984625,-0.05941523,0.11637315,-0.023467856,-2.5009133e-33,0.02866709,-0.07435032,0.102722436,-0.037755117,-0.04246826,0.056736425,0.039127108,-0.05990571,0.09070124,-0.08314027,0.081602685,-0.095198214,0.037683267,-0.09120466,0.021271748,0.0013125793,-0.06319885,0.059286196,-0.06703735,-0.029981215,-0.08059146,-0.028120175,0.027639838,0.06972017,0.043113336,0.021299036,-0.05026614,0.033541866,-0.03461081,0.043082684,0.0015145444,-0.0045388234,-0.12244493,-0.08301042,0.016380986,0.028996088,-0.07565435,0.020232765,-0.024403617,-0.101132296,0.079274304,0.12991628,0.04381696,0.06378803,-0.05120492,0.09381874,-0.008703431,-0.019196462,-0.03612007,-0.0651959,-0.00030250475,-0.037103288,0.012849764,0.018355493,0.09933218,-0.054884184,0.049277287,0.016120223,-0.044402096,0.06479557,-0.044883728,0.0052573597,-0.012220183,0.0493679,0.063206024,0.06326362,-0.07182783,0.04199495,0.13612923,-0.015791317,0.045409855,-0.042608786,0.064226545,0.053994287,-0.02610575,0.051383786,-0.025050156,-0.06967958,0.025868975,-0.1125824,-0.016488377,-0.0057066698,-0.05363829,-0.016182505,-0.03212935,-0.021217791,-0.0148706185,0.04371069,0.07624073,0.008930992,0.011244583,-0.012449731,0.08534692,0.029039886,0.034004603,-2.4345315e-08,0.10603047,-0.055420868,0.05653595,-0.074108474,-0.10030753,-0.003090825,0.018882418,0.029213963,-0.002312066,-0.025651341,-1.4297379e-05,0.013157936,-0.040535145,-0.06587825,-0.026766209,0.0053535746,-0.0063695293,0.055811975,-0.0049401643,0.012793183,-0.068520814,-0.012788028,-0.06629041,-0.029036738,-0.002327178,-0.061407723,0.0057350276,0.00381744,0.039715596,-0.08224186,-0.013934626,-0.03388693,-0.027157182,0.06911802,0.05785264,0.029947277,0.023887126,0.03959031,0.016680874,0.007352767,-0.009016882,-0.016675048,0.001971662,-0.07586602,-0.056194156,-0.024090128,0.069674954,-0.0032019566,0.01642114,-0.013719091,0.038743384,0.049472302,-0.027077226,-0.08244754,-0.059617866,0.0027921917,-0.0005496831,-0.052990373,0.008669661,-0.049252138,0.026768707,-0.045537494,0.12063124,0.08049904 +3.4.21.10,Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family),384,1.0,-0.055088554,-0.004736489,-0.1345372,-0.060766157,0.04509114,0.038380947,0.03793597,0.06578558,0.044776447,0.09109218,0.0692572,0.03323827,-0.046176296,0.09942156,-0.06851317,-0.030526808,-0.013955911,-0.06358847,0.035794362,-0.03644771,0.0813865,0.02786019,-0.0134774,0.034507632,-0.05868798,-0.05080586,-0.0146797225,0.06714396,0.03359014,0.017610252,-0.036657285,0.038190603,0.025248935,-0.05547456,0.05294961,0.032938804,-0.050659176,0.029587867,0.056927953,-0.032159228,0.08191813,-0.040108804,-0.051609807,-0.043341205,0.009242726,0.009743405,0.05594166,0.09367288,0.15138589,0.036963556,-0.04072808,-0.10953786,0.04416815,0.017928353,0.040008925,-0.045133337,0.012320375,-0.051310185,0.02013353,0.032227695,-0.07356343,-0.0054075094,-0.008808259,0.0029124164,0.047117155,0.022020794,-0.010483452,0.020783879,-0.048196126,0.012360339,0.04963529,0.0025707693,0.000831266,0.14725828,-0.025692247,0.0387069,-0.023628572,-0.066771045,-0.079716995,-0.07528213,0.0069958894,-0.06556468,0.016729966,0.06321404,-0.029581286,0.0056488616,0.04916021,-0.031013208,0.051542,-0.037089057,-0.014429374,-0.034792293,0.067697205,-0.019960752,0.0037331327,0.01491593,-0.0713577,-0.08095207,0.0012222504,-0.026827171,0.022451408,-0.026474524,0.036377575,-0.09095733,-0.025050573,0.07238817,-0.0950991,0.031568278,0.057653826,0.016541105,-0.011263213,-0.017149247,0.06256424,-0.001368958,0.018893689,-0.014614762,0.048109874,-0.0027377545,-0.055411518,0.02274606,0.020071281,0.018351225,0.00043422106,-0.004873016,0.010347531,-0.001548045,-0.021662014,2.5485516e-33,0.05654528,-0.052291892,0.02898924,0.090314254,0.009509157,0.0928338,0.015001935,-0.07922885,0.01711911,-0.102436334,-0.08854308,-0.09677017,-0.018824738,-0.060604777,-0.07402053,-0.021308122,0.00581592,-0.073267505,0.03498771,0.0657642,-0.043980364,0.06288231,-0.01312317,-0.12792219,0.015553148,0.05663552,-0.049119174,0.0036888348,0.016789557,-0.03944514,0.027224116,0.04388649,-0.11663975,0.047050964,0.041438,0.025403444,0.08078514,-0.048817057,-0.020886973,0.03897643,-0.0056144265,-0.041245468,-0.0125308605,-0.018464388,0.04470474,-0.06973937,-0.033445597,0.04082973,0.062206622,0.031442992,0.05665489,-0.024426969,0.07289648,-0.0064250864,-0.095084056,0.0014976867,-0.026443807,-0.062883005,0.0400646,0.025647847,0.060859215,-0.027941817,-0.055558953,0.07968834,-0.024661565,-0.033005245,-0.057394773,-0.07863595,-0.048729356,-8.6892076e-05,-0.074793,0.008537432,0.10570017,-0.012166663,0.013448594,-0.049760576,-0.05518274,0.065933816,-0.0037450537,0.036845725,0.013057997,-0.042973712,-0.07174391,0.044526055,-0.08682089,0.056919605,0.03222247,-0.012352338,-0.026309319,-0.0470253,0.026741127,-0.06669735,-0.016229425,0.006775933,0.0071230754,-4.592893e-33,0.059541363,-0.084580876,0.10140239,-0.013770972,0.018615287,0.029591732,0.062698446,-0.017742075,-0.034130048,-0.030324362,0.03462121,-0.12706815,0.083399214,-0.08055055,-0.0012188224,0.009955751,0.00084901496,0.08673457,-0.014959482,-0.06326135,-0.020786775,0.020851843,0.0816823,0.039358195,0.036583297,-0.043325793,-0.019346721,0.03714152,-0.018418146,0.03426496,-0.052806005,0.06022417,-0.08139946,-0.03345821,0.0020832238,0.0140434,-0.07352654,0.01138729,0.05878524,-0.1074439,-0.014319584,0.045120955,0.041201826,0.0627487,-0.022723334,0.09354592,-0.016890666,0.037351735,0.012209469,-0.01797333,-0.039888047,-0.049987055,-0.056114074,0.011659193,0.089549154,-0.04698624,0.004535568,0.032435007,0.024347624,0.10654517,-0.026476532,0.027153263,-0.032892242,0.08005661,0.03249837,0.005268992,-0.11108237,0.03893821,0.11915941,0.05360171,0.08741854,-0.032455385,0.058385514,-0.0011762881,-0.03201308,0.04846889,-0.0651468,-0.06307886,-0.00039268826,-0.07576701,-0.009471273,-0.03413225,-0.02510989,0.082467556,-0.07157665,-0.055480223,0.058228903,0.015737884,0.006752167,0.009867444,-0.029529672,0.016361834,0.05816112,0.05048843,0.032922875,-2.850112e-08,0.07204449,-0.05586827,0.048366345,-0.07988319,-0.0010087513,-0.036649484,-0.0023302776,0.017889364,0.086477235,-0.08103491,-0.06632787,-0.03528972,0.04453222,-0.030822704,0.010683101,0.078589424,0.026411772,0.07427101,-0.00414633,-0.00842275,-0.017831791,-0.07477048,-0.082418844,0.052707046,-0.04799238,0.02171653,0.014263001,0.0038258599,0.010862283,-0.086523816,-0.02326258,-0.012978416,-0.022794945,-0.027643725,0.043993574,0.1130831,-0.06956613,0.027220089,0.027024433,-0.061626907,-0.014238125,-0.06425884,0.00022433465,-0.06429049,-0.060212202,-0.0040334323,0.019938583,0.038633943,-0.014885795,-0.024866013,-0.005483571,0.046085723,-0.01770133,-0.022176117,-0.005840599,-0.013217502,0.0498909,-0.037277445,0.036627907,-0.010793056,0.01163095,0.04155385,0.0846397,0.04178562 +3.4.21.12,From the myxobacterium Lysobacter enzymogenes. In peptidase family S1 (trypsin family),384,0.99999994,-0.054686178,-0.05589853,-0.1180774,-0.007019639,0.029613769,0.055539746,-0.0005540673,0.11084045,-0.047725786,0.037153374,0.06930691,-0.08160288,0.03845541,0.06836351,-0.051089667,0.058817983,-0.048801072,-0.050409544,0.024135074,-0.012679744,0.011460122,0.042976666,-0.0046069263,-0.012568155,-0.042895954,0.005035107,0.014525862,0.0005313549,0.006067808,-0.026223727,-0.004474831,-0.029806184,0.07817281,-0.070944965,0.11866753,0.05708958,0.0143774105,-0.079773605,0.12617935,0.0018043284,0.066299304,0.024775842,-0.005560624,-0.010818612,-0.028009236,0.025151111,0.015256919,0.09123712,0.039880633,0.013808258,-0.050801992,-0.09292272,0.017179558,-0.00083437224,0.020702485,0.044298355,-0.0073782527,-0.014427906,0.028635722,0.039044693,-0.013117474,0.016527057,0.09429729,0.009924335,-0.021180829,0.0021370617,-0.048715644,-0.039293557,-0.013284516,-0.021339534,-0.08766048,-0.024705205,-0.058307476,0.19075647,-0.004312446,0.017673219,0.037112948,-0.009809045,-0.031167556,-0.044061784,-0.06309984,-0.07841398,0.015051207,0.04498107,-0.009020563,-0.060948223,0.0796916,0.013440965,0.040430088,0.0108259665,0.06624873,-0.040196974,0.053267058,-0.038412385,0.008348745,-0.05148986,0.0022115044,-0.044552743,-0.003435438,-0.085467555,0.0034934026,-0.09568101,0.07661155,-0.043037843,-0.064634554,0.00832725,-0.0896331,0.020788295,0.05479765,0.025740067,-0.056747545,0.030956933,0.067183994,-0.051978678,0.054593462,0.026407363,0.086826175,-0.007989952,-0.04012008,-0.019026134,0.060047723,-0.019128047,0.05391356,0.048144296,-0.05252832,0.06131664,-0.08175861,2.4378036e-33,-0.015809905,-0.030031534,-0.011735572,0.029693266,-0.024291486,-0.029657396,-0.012902093,-0.00041855834,0.021922832,-0.010564966,-0.11292692,-0.048158847,-0.0021783903,0.005262555,-0.09833827,0.06684117,-0.08099292,-0.015283564,-0.0047342074,0.10869164,-0.07830918,0.027752934,0.055924844,-0.086689524,0.052396853,0.07751304,0.026255757,-0.11019816,0.0693337,-0.042014945,-0.021498019,-0.06414725,-0.13841173,-0.025341986,-0.018112546,0.010332485,0.0981262,-0.09563207,0.011062724,-0.046909202,-0.020112861,0.03707487,0.029043071,-0.06205159,0.1187032,0.00685077,-0.07342883,0.036019284,0.02603363,0.008415063,0.07512019,-0.08955862,0.06674759,0.004007934,-0.02373056,-0.023531925,-0.0116479285,0.029247364,0.055596173,0.041551337,0.110676266,0.08726515,0.01760487,0.051700078,-0.042141415,-0.050467193,-0.0031923556,-0.037446648,-0.030937472,0.020440938,-0.020942023,0.003171948,0.05721489,-0.035527106,0.035229787,-0.09266097,-0.057236906,0.047447793,-0.020197293,0.038587738,0.045458354,-0.014923099,-0.030537637,-0.010847167,-0.0056664916,-0.036380433,-0.0151401,-0.015017172,-0.06673635,-0.021795083,0.034043,-0.01767415,-0.06314724,0.10917608,-0.055182606,-4.1031126e-33,0.023648916,-0.11285361,0.08103448,-0.039794065,-0.011374847,0.012623632,0.03214046,0.056184463,0.057706248,-0.03856666,0.043311812,-0.026868764,0.0185367,-0.09214611,0.04104569,-0.0075941677,-0.033599447,0.084265254,-0.06296656,-0.07519071,-0.014942226,0.011470179,0.032396894,-0.006454846,0.024352456,0.02718954,-0.0056756027,0.12365141,0.0095420545,-0.012785747,0.011457233,0.0066138916,-0.065016896,-0.11596592,-0.02254155,-0.013262323,-0.10076757,0.0011712061,0.071751624,-0.11868139,0.022622019,0.06951579,0.04474449,0.09037037,-0.059865225,0.04171198,-0.06911159,-0.06503592,0.023761028,-0.021992527,-0.03907084,-0.08307808,-0.0085286675,0.014902754,-0.025293633,0.018512784,0.004609225,0.03928455,-0.07286256,0.031718347,-0.03722551,0.008211312,-0.0039427765,0.08240841,0.044605955,0.06415862,-0.036641277,-0.005318801,0.08513523,-0.02941202,0.09416245,-0.010485739,-0.0077182315,0.056451526,0.021259487,0.044831447,-0.07119325,-0.052416112,0.070186995,-0.052901942,-0.0053424076,-0.04352561,0.014024901,0.04503184,-0.0025045916,-0.09166487,0.020384312,0.048037387,0.03502991,0.01566471,0.01176259,0.02809271,-0.0038442158,0.0016166498,0.044204492,-2.595014e-08,0.047175422,-0.065252095,0.0676101,-0.017744126,0.017390508,-0.0038392318,-0.100854054,0.0028354432,0.04788749,-0.010283014,0.042336363,-0.024523335,-0.03968122,-0.024014728,0.019471493,0.0027243048,-0.04409512,0.06375478,0.025487028,0.024868963,-0.05041838,0.003923622,0.012118462,0.011108081,0.018601194,-0.05510953,-0.0048638973,0.049951125,0.061653297,-0.00065875764,0.0012294629,-0.03234451,-0.005755976,0.0053872066,-0.055313427,0.05194605,-0.073661886,-0.035030495,0.027338965,-0.06018059,-0.009348978,-0.055489738,-0.014038841,-0.038216095,-0.05828682,0.012006577,-0.0478293,-0.031737823,0.010413926,-0.03727632,0.0053850017,-0.006152846,-0.010059255,-0.014382125,-0.06486964,0.066356,-0.007363872,0.0013997699,0.019176364,-0.027093902,-0.028739503,0.07303913,0.11662855,0.078219585 +3.4.21.19,From Staphylococcus aureus strain V8. In appropriate buffer the specificity is restricted to Glu!. In peptidase family S1 (trypsin family),384,1.0,-0.019610971,-0.04556939,-0.10420569,-0.075541876,0.010374763,0.021946596,-0.029759703,0.111584015,0.032600593,-0.026154688,0.057206612,-0.07493798,-0.037326608,0.13922043,-0.09001965,-0.07242715,-0.013670147,-0.02880081,-0.0048460145,-0.06741214,0.04586428,0.10338413,-0.05494202,-0.034905452,-0.044994097,0.0105264755,-0.039500616,-0.010514819,0.06145663,-0.03324872,-0.07305433,-0.05057347,0.05413664,-0.027000813,0.061930645,0.02340909,-0.0053316485,-0.032591566,0.105366856,-0.013378303,0.014580137,0.054666042,-0.014164335,-0.0011238134,-0.0025286835,0.047972072,0.021909794,0.097017996,0.07046021,0.0023423026,0.014864457,-0.015425319,0.0076830518,0.030623375,0.0575788,-0.0483649,-0.08086963,-0.062745124,-0.016718568,0.00049808767,-0.029874627,-0.06728842,0.038584568,-0.0419596,0.004885943,-0.04362472,0.012166749,-0.020945273,0.022096615,0.047775477,-0.040638976,0.008329333,-0.05372167,0.115817,0.014123384,0.09557127,0.027436344,-0.06958583,-0.019040458,-0.035025496,0.04716701,-0.021560667,0.05488374,0.1442184,0.024789311,0.011721503,-0.0020066027,0.04177518,0.007738434,0.0050973166,0.06735598,-0.06615044,0.03041412,-0.02618663,-0.009780493,0.00786889,-0.034921438,-0.100804485,-0.0038073116,-0.029622167,-0.05197173,-0.03716542,0.0850942,0.0010710893,-0.013667081,-0.0011356304,-0.03982126,0.045716465,0.037243195,-0.046656746,0.027750097,0.03962642,0.05891283,-0.083202615,-0.009280009,0.010909838,0.026271442,-0.07554656,-0.052290563,-0.00055573846,-0.0027098556,-0.017079033,-0.017103385,0.046516523,-0.03929237,0.024352081,-0.03256592,3.0111032e-33,-0.021453612,-0.07041987,0.028595524,-0.022834906,-0.011548181,-0.040343013,-0.071759276,-0.04466445,0.03698328,-0.03808221,-0.12630153,-0.10682066,-0.010364746,0.00953846,-0.035287786,0.068347044,-0.034396064,-0.00465112,-0.0061591193,0.008936775,-0.012699771,0.092962906,0.027391324,-0.1127769,0.06384048,0.029007431,0.021148555,-0.021835256,0.049638942,-0.028726283,-0.057417385,-0.01102279,-0.06427974,0.005593996,0.0056033977,0.015251528,0.01286958,-0.048616156,0.019803924,0.0066917106,0.034278244,0.09234024,0.015049255,0.03172735,0.09137201,-0.03207219,-0.08526379,0.027150232,-0.032331407,0.08391343,0.06703092,-0.021654284,-0.029648084,0.018737977,-0.05276369,-0.038358666,0.014452133,0.031194925,0.081881724,0.09335958,0.042094685,0.07241223,-0.03999209,-0.0015243543,0.00943597,0.013910931,-0.02516608,-0.030147165,-0.036584992,0.04816061,-0.06941658,-0.0012984889,0.055302594,0.009449935,-0.017020913,-0.064300105,0.036282722,0.094105616,0.057095878,0.005136003,-0.01545245,0.009061891,-0.009430733,0.021568557,-0.19641444,-0.032242406,0.055371165,-0.0345209,-0.029231133,-0.0037700958,0.0041643884,-0.016671568,-0.04216211,0.09384625,-0.06416535,-4.3169564e-33,0.082373574,-0.13989495,0.07159507,-0.058408674,-0.051585503,0.108065404,0.048710536,-0.025269808,0.036862493,0.0134282205,0.054779705,0.018525789,0.029653901,-0.005242271,-0.015668005,-0.00833832,-0.04733447,0.08305551,-0.040323965,0.010096662,-0.047036804,0.022548713,0.060458202,0.058979165,0.06404991,0.041799158,0.0014097646,0.019702453,-0.014125164,-0.034244295,0.006608884,-0.013692749,-0.09254394,-0.038344007,-0.01359087,-0.015647756,0.015311436,0.03805902,0.008107084,-0.07340196,0.07026404,0.09771167,0.04031902,0.06353566,-0.005537017,0.1089143,-0.019040387,-0.017081413,-0.02430172,-0.06582011,0.04308737,-0.020739514,-0.0076193013,0.036640022,0.024942908,0.011312904,0.084628,-0.018186979,-0.052882828,0.027278014,-0.044068895,-0.06978975,-0.05637745,-0.0068738367,0.041071292,0.0024075813,-0.029178703,-0.054864246,0.06398996,-0.005539302,0.01703015,-0.037531104,0.03708718,-0.033171564,-0.0265717,0.00024028007,-0.07473626,-0.13682686,0.054696262,-0.029881263,-0.046911612,0.00889413,-0.007086811,0.10029252,0.06381632,-0.04223133,0.007377458,0.054335583,0.076185785,0.037335325,-0.022673272,0.021878442,-0.009465489,0.028157823,0.03680425,-3.094025e-08,0.09808189,-0.029740682,0.039064184,-0.015180638,-0.06058004,-0.009914409,-0.083397776,-0.016278032,0.05425482,0.026032886,-0.0113430135,0.019605627,-0.08466318,-0.06741352,-0.0035002383,0.033567328,-0.119701594,-0.015397207,0.016159665,-0.046053704,-0.09696158,0.0014598558,-0.044174403,-0.0063929697,0.005767913,-0.0495139,0.03205561,0.054380428,-0.012618692,-0.08954917,0.041160665,-0.0003122715,-0.056163594,-0.01196922,0.005048884,0.029000342,0.007062629,-0.009890036,0.031036833,0.048448607,0.03627854,-0.04078765,-0.032972634,-0.02999271,-0.052276496,0.027462726,-0.014917964,0.023869023,-0.021574132,0.003183357,0.0703713,-0.049749177,-0.021155376,0.02968503,-0.11687273,-0.0064646676,-0.026839996,-0.08929908,-0.0006688632,-0.0069321217,0.070366025,0.036064718,0.14697506,0.11839196 +3.4.21.20,From azurophil granules of polymorphonuclear leukocytes. In peptidase family S1 (trypsin family),384,1.0,-0.0490821,-0.038618382,-0.047984436,-0.051194377,-0.014073033,0.07433094,0.073096946,0.105398774,0.07741403,0.08203986,0.029793479,-0.015759954,0.06911963,0.12702718,-0.07910903,0.015137222,-0.0439898,0.032912157,-0.04998257,-0.07268131,0.05758478,0.018269667,0.014179014,0.0068836166,-0.06567216,0.039242733,-0.041700847,-0.01606835,0.011020925,0.04476988,-0.053794794,-0.095110536,-0.0027944904,-0.06647174,0.078485295,0.0035806093,-0.02506018,0.026404731,0.03767437,-0.017699547,0.075078584,0.037232567,-0.05686174,-0.0018091837,-0.048826497,0.0650028,0.021365466,0.059941214,0.030342827,0.01731879,0.041489076,-0.034440383,0.060030416,0.0017780296,0.019256573,0.06928933,-0.08516679,-0.047621384,0.04178977,0.035778333,-0.05033963,-0.009340033,0.090852395,-0.019788163,-0.012626771,-0.038643572,0.05543146,0.007775044,-0.05752934,-0.02434006,-0.01623035,0.032369327,-0.06595203,0.10930972,-0.029317891,0.03630397,0.029857136,-0.10926143,-0.075413354,-0.04685045,0.026513385,-0.010896605,0.082897864,0.1415922,-0.0025588612,0.014678377,0.032610204,0.03826601,-0.028569568,-0.033057924,0.046416048,-0.07817854,0.03701988,0.0013941141,0.04898247,-0.039469287,-0.031824548,-0.05091023,0.05389718,-0.0339871,0.002278789,-0.1152328,0.09087625,-0.1071985,-0.04716561,0.049423795,-0.06941715,0.021144014,0.071118906,0.034613453,-0.01085593,-0.037298206,0.08854802,-0.024138544,0.053498738,0.001580626,0.06998841,0.042164326,-0.046013225,0.043440312,0.011058678,-0.03068225,-0.051098336,0.07684368,0.018681467,0.029228091,-0.025137367,2.9210377e-33,-0.018321693,-0.012751893,-0.022235576,0.061664205,-0.06108515,0.045263637,0.070419036,0.018940069,0.02460074,-0.025614861,-0.094970934,-0.10982374,-0.015295749,0.020995352,-0.113377206,0.079122975,-0.08026425,-0.095981,-0.005674768,0.013232481,-0.0667218,0.11020782,0.029006947,-0.08919631,0.027421398,0.02815656,-0.053257223,-0.07678369,0.06644196,-0.050410986,0.02053452,-0.0017651339,-0.13138781,0.051159047,-0.0357173,0.09423695,0.073656246,-0.028255131,-0.07293952,-0.0047621024,-0.031698253,-0.008557589,-0.03771263,-0.026888924,0.082570605,0.0055162623,-0.10494272,-0.013808983,0.025690308,0.008421234,0.035941288,0.0034576135,-0.008953397,0.004826687,-0.037986606,-0.053332992,-0.033064373,-0.01621877,0.044044115,0.05895331,0.073565885,0.005387188,-0.039738286,0.027930755,0.054600004,-0.031930517,-0.030930938,-0.033463232,-0.015329424,-0.012070209,0.06926215,0.039348252,0.019882355,0.018888012,-0.0025396415,-0.039334267,-0.0060534147,0.062482603,-0.00965638,0.109463416,0.052770652,-0.021223152,-0.030091789,-0.014733584,-0.07751823,0.017404541,0.08822499,-0.010582429,-0.013743923,-0.04089624,0.05750232,-0.058925845,-0.0631862,0.061565757,-0.07130141,-3.884953e-33,0.034443952,-0.07937717,0.07027272,0.035739455,-0.055099476,0.040995922,0.040907603,0.102056906,0.014237141,0.015919931,0.11068947,-0.03564493,-0.019811897,-0.03376908,0.04122769,-0.020023182,-0.0008685599,0.067639336,0.05223145,0.022775626,-0.11743484,0.028618267,-0.07961534,0.09394524,0.07936881,0.009470149,-0.056112524,0.0066225687,0.027352914,-0.007513449,-0.022149935,-0.0087748505,-0.06792114,-0.07978947,0.010512582,-0.03708487,-0.047456037,0.0006196446,-0.036646225,-0.06022912,0.003566648,0.0105907265,0.088532425,0.084101446,-0.0015784807,0.09454233,-0.03562543,-0.003606121,0.020324396,-0.07053133,-0.026645971,-0.054372113,-0.0077461153,0.023577537,0.09086067,0.0052945684,0.04099053,0.032136932,-0.03554296,-0.02627542,-0.049035333,-0.017984482,-0.031393886,-0.001549509,0.013265466,0.07903048,-0.0043647527,-0.07850844,0.04349196,0.0004656478,0.002462425,-0.026839212,0.09128294,-0.045716025,-0.00069395395,0.016174484,-0.06573881,-0.004715987,0.0250638,-0.0508207,0.020685295,-0.015600194,-0.03313963,0.021595104,0.04946305,-0.033960614,0.003376568,0.05158814,0.002632984,-0.03292429,0.026272288,0.028815022,0.072411336,0.059608933,-0.0015670976,-2.8809774e-08,0.10582593,-0.06868238,0.0035505693,-0.09667238,-0.07535952,-0.042896077,0.014688972,0.02608753,-0.015140334,0.034467515,0.014195713,0.00061392126,-0.002118126,0.01821983,0.055484496,0.04758612,0.00928076,0.02216985,0.0615057,-0.07360306,-0.07791396,-0.0069912737,-0.06397031,-0.019105319,-0.056358464,-0.027813014,0.01377163,0.009456501,0.03345512,-0.07388512,-0.0013539634,-0.0019432436,-0.037646353,-0.058690082,0.0033639485,0.052960303,-0.00716118,-0.067833886,0.0413878,-0.060997494,0.021529825,-0.011371458,0.045032516,-0.07037283,-0.0076255975,-0.08618014,0.001724711,-0.08009723,-0.01590926,-0.079148434,0.0071684853,-0.039497703,-0.03453839,-0.011399409,-0.05522521,-0.018707788,0.034448415,-0.044425227,0.00739035,0.016357517,-0.06400364,0.03956442,0.07279176,0.028773993 +3.4.21.21,Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family),384,0.99999994,-0.06360912,-0.05831689,-0.04818822,-0.0062880875,0.06278539,0.04728847,-0.0154164275,0.10680249,0.022589277,0.057884347,0.0634073,-0.03644412,-0.05027712,0.09884214,-0.07029542,-0.03989907,-0.008391398,-0.05691329,0.004735441,-0.0766061,0.011345122,0.0020612048,-0.036325905,0.029562004,0.005750199,-0.026142439,0.0059844702,0.017387263,0.061639722,0.0052464535,-0.09606474,-0.030951114,0.06561601,-0.07364197,0.020359514,-0.021141939,0.09208705,-0.011874616,0.032432605,0.037237838,0.0501777,-0.03857475,0.025209963,-0.034405876,0.046070483,-0.017636852,-0.00512178,0.09991164,0.0885918,0.057725,-0.05278636,-0.032422762,0.019544646,-0.020014629,0.034080356,0.012744952,-0.03346977,-0.0022232363,-0.029235326,-0.0015685464,-0.02746074,-0.018299611,0.044632334,-0.0034758796,0.09096622,-0.026304271,0.006032772,-0.031684462,-0.0429474,0.024978634,-0.019197313,-0.032300547,-0.038526185,0.050654627,-0.008535616,0.122135945,-0.00041923497,-0.06568917,0.0023835795,-0.06685086,0.06344141,-0.013666765,0.051057696,0.08140179,-0.0074907527,0.015403552,0.015510331,0.027176388,0.00405297,-0.039065618,0.0438017,-0.08087595,0.028976839,-0.024663432,-0.018467078,0.044522252,-0.089885116,-0.010200289,-0.0033517112,-0.0061783153,0.016479246,-0.054615807,-0.043825354,-0.061905272,-0.042181086,0.10195062,-0.098659694,0.059451237,0.06193387,0.037046846,-0.06041724,0.0058467905,0.039588857,0.03279802,0.049309235,0.041935463,-0.0077314298,-0.054692946,-0.086011335,-0.03161118,0.09434281,0.020938348,0.046285506,0.12207954,0.0007532283,0.008765399,-0.04212277,2.4995833e-33,0.052334838,-0.023974452,0.044325065,0.0139617855,-0.043116707,0.030072639,-0.085630976,-0.0032786988,-0.058710884,-0.034410328,-0.0967129,-0.10030831,0.027234634,-0.049810212,-0.05828728,-0.0057086106,0.0024430412,-0.055924274,0.028450245,0.009506232,0.024997158,0.07626251,-0.011749217,-0.07281729,0.028098436,-0.007477479,-0.03090717,-0.022773309,0.032498248,-0.024260279,-0.05298497,-0.11988442,-0.12015419,-0.011624107,-0.022759253,-0.06389174,0.051061537,-0.09342986,-0.0031563875,0.01623967,0.027919497,0.04687482,-0.0021154396,-0.056775805,0.09104074,-0.02062978,-0.024359934,0.043571614,-0.009788844,0.007763474,0.042074166,-0.014630878,0.09763216,-0.059753135,-0.031210527,-0.012800121,0.008682186,-0.03963028,0.04152543,0.04681088,0.014011084,-0.0066914493,-0.025394522,0.05518472,-0.02008563,-0.04284757,-0.0019834924,-0.07406867,0.016842976,0.100842886,-0.044086132,0.0106719,0.030410161,-0.039352234,0.043649733,-0.100293145,-0.00544443,0.10558377,-0.033948828,0.039544463,-0.011435783,-0.011626806,-0.07048548,0.03494026,-0.07503741,-0.04148779,0.014973355,-0.0095055485,-0.02274463,-0.027458167,0.061507836,-0.048653014,-0.011170972,0.03963721,0.044901237,-3.0489655e-33,0.030455457,-0.07790153,0.11432992,-0.043030303,-0.088401385,0.037954826,0.08061611,-0.019945553,0.06486878,-0.061545707,0.08559797,-0.05068983,0.015575486,-0.061251376,0.041880745,0.020337217,-0.023804517,0.12100775,0.034843255,-0.078124665,-0.06820425,0.003689772,0.012508041,0.0949333,0.041049857,0.06737679,-0.062465098,0.052485745,-0.0011889462,0.020051543,-0.07609358,0.000272228,-0.07659559,-0.08326866,-0.006195139,-0.01100641,-0.08457647,0.0015389185,0.022392021,-0.040298205,0.047387242,0.14937687,0.07938867,0.019238314,-0.061228123,0.10592339,-0.01930641,0.0020377738,0.04082603,-0.043613344,0.024796905,-0.008296421,-0.018600916,0.037839282,0.069944635,0.015350881,0.049550064,0.004087968,0.0024357545,0.060587734,0.0011578216,-0.0113954805,-0.014484551,-0.02843519,0.032627434,-0.0077759153,-0.05179211,0.0460264,0.08388137,-0.06429387,0.07010291,0.011963756,0.05129203,0.06469465,0.015531039,0.0333357,-0.029018516,-0.041207284,0.015934952,-0.060801726,-0.08223351,-0.06364495,-0.054921154,0.024110658,-0.023639653,-0.049293008,0.023107497,0.09136164,0.12620084,0.009362063,-0.019031877,-0.043846607,0.03790887,0.049453355,0.05515754,-3.4295656e-08,0.052088346,-0.082782455,0.030858709,-0.08780872,-0.045633104,0.025768306,-0.04043278,-0.0042181243,0.05093919,-0.011940925,-0.0019816183,0.040110845,-0.0076444787,0.039992407,0.03568299,0.038270283,0.0037970713,-0.00084222644,0.0034556133,0.030656002,-0.047628332,-0.028010968,-0.09699727,-0.031020856,-0.038180795,-0.073506616,-0.016753728,0.067827076,0.035339106,-0.047499776,-0.030695105,-0.022088867,-0.026861547,-0.045937955,-0.026086608,0.082081236,-0.035547696,0.012669582,0.0039588334,-0.0156353,-0.004203979,-0.06476482,-0.025533982,-0.045786433,-0.021090668,-0.044976477,0.058208205,0.014020097,-0.00016419488,-0.062124614,-0.051897407,-0.0033068187,-0.016986635,-0.07043879,-0.041208107,-0.028805323,0.022780702,-0.06670958,0.0890324,-0.062484004,0.09509083,-0.021319335,0.17440213,0.06699672 +3.4.21.22,"A chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family)",384,1.0,-0.053731702,0.017002886,-0.07177405,-0.012018471,0.08927369,0.11535216,0.059937716,0.0872755,0.0213038,-0.00844208,0.07413163,-0.049613275,0.009145834,0.11117812,-0.04480456,-0.017188912,-0.052940577,-0.025524579,-0.003543983,-0.09602159,-0.07331183,0.01600499,-0.0061069326,0.015557075,-0.05608217,-0.002429492,0.02567078,-0.05680574,0.060686808,0.03267484,-0.05233261,-0.002487121,-0.024703588,-0.042423382,0.028828666,0.015585349,0.07514088,-0.049571253,-0.037956372,0.03424295,0.0668172,-0.042405363,-0.053937912,-0.020538423,-0.006949563,-0.012691277,0.04679486,0.11698996,0.0042805974,0.06792021,0.023475412,-0.01310894,0.03387777,-0.0066205873,0.03960276,0.09047509,-0.054741956,-0.028957266,0.027425941,0.033030245,-0.024858788,0.038921703,0.010189714,0.022752814,0.012633318,-0.05768838,0.0076224483,-0.005816393,-0.07500319,-0.012754911,0.0046057277,-0.0059087137,-0.13756517,0.086746216,-0.037712917,0.040020075,-0.057067227,-0.10034628,-0.003043826,-0.02558397,-0.028089747,0.009622945,0.11207699,0.12940998,-0.03799458,-0.014809419,0.017112417,0.035372153,-0.04413872,-0.03637921,0.03465089,-0.10554693,0.11668857,0.02514043,0.022645501,0.08067647,-0.03263664,-0.07608521,0.016187169,-0.018728774,-0.028045706,-0.043281548,0.026934164,-0.0031714388,-0.03715277,0.015070687,-0.13483255,0.07328922,0.060678776,0.024372447,-0.014215962,-0.10386793,0.07155212,-0.046951283,0.092947,0.057989735,0.0065343743,0.024103897,-0.014304682,-0.032929223,0.08499203,0.03169405,-0.04491967,0.072664015,0.061830774,0.017627804,-0.02247881,4.2236232e-33,0.04832597,-0.0037884843,0.033841748,0.016659202,-0.043625224,-0.026025014,-0.026264794,0.017646918,0.0027132134,0.028134985,-0.085795425,-0.059315994,-0.039940465,0.019710273,-0.068326585,0.00592832,-0.08477353,-0.041787565,0.031040465,0.04798637,-0.051043514,0.10545177,0.024965106,-0.02265369,0.06452511,0.06752742,-0.016970856,0.02585034,0.026969457,-0.020207433,-0.034068156,0.0078033865,-0.1214428,0.0150157055,-0.07864189,-0.00798238,0.07262414,-0.0899116,-0.04027094,0.06777105,0.0790732,0.005300963,-0.06840567,-0.064777955,0.08325992,-0.028025659,-0.050981373,-0.05255585,-0.021468047,0.045042604,0.042742994,-0.016275428,0.08082925,0.015828755,0.015191394,0.017360274,-0.036423825,0.02951596,0.024731085,0.032922093,0.0072963773,-0.026245626,-0.02870821,0.070919275,-0.01502106,-0.016555183,-0.03266907,-0.12033662,-0.06194778,-0.04903594,-0.037704162,0.0727046,0.06706879,-0.022107152,0.059272137,-0.09225287,-0.061637156,0.10472252,-0.031151904,0.032684214,-0.05101644,-0.009616795,-0.008586591,-0.01987455,-0.024277568,-0.053694457,0.051671244,-0.00093815825,-0.05929161,-0.09833009,-0.009227368,0.01728951,-0.028192792,0.09368188,-0.013817132,-5.533858e-33,0.03650234,-0.13710979,0.07635985,-0.030392576,0.02325482,0.04159565,0.06368181,-0.062434055,0.05958772,-0.027046137,0.033249523,-0.029241377,-0.03486761,0.023666872,0.062013086,0.0070807417,-0.0021378829,0.078197286,-0.06545719,-0.013390723,-0.08602395,0.0061827237,0.01509409,0.029447937,0.09365349,-0.012270669,-0.010686566,0.003934168,-0.019452173,0.029840203,-0.037555795,-0.03376681,-0.087701485,-0.07647774,-0.0022835974,0.008313745,-0.034227654,0.07021101,-0.027019156,-0.05587345,0.026200917,0.06544872,0.08289554,0.034228858,0.01730182,0.121528625,0.005598442,-0.018754529,-0.011841657,-0.05807271,-0.092748374,-0.06529159,0.018536782,0.07655162,-0.003039752,0.019962069,0.033840407,0.0711339,0.008907689,0.0084099835,0.0012381824,-0.009226111,-0.0023139436,0.03716665,0.056768756,-0.016777424,-0.035531305,-0.06365937,0.079944335,-0.038489763,0.05626475,-0.061549347,0.0723367,0.051927317,0.0026908577,-0.0047515486,-0.08627203,-0.026944507,-0.0044149347,-0.0724579,-0.033393577,-0.03463366,-0.040158577,0.02242003,-0.00855806,-0.021719093,-0.018271482,0.057261564,0.11887109,-0.008277368,-0.03386164,0.026365919,0.014778936,0.029846914,0.009806603,-3.7839023e-08,0.060681663,-0.048718873,-0.03195351,-0.10779459,-0.0275449,-0.03606395,-0.017225862,0.015589318,0.07926587,-0.02420201,0.048495784,0.03620776,-0.0100352205,0.0023001393,0.008953376,-0.025705598,0.04104765,0.004863012,0.026758544,-0.03962343,-0.047187824,-0.047357243,0.05522975,0.0010414094,-0.04260917,-0.05331802,0.024034245,0.017722666,0.033359427,-0.024653137,-0.030072086,0.018870907,-0.019574067,-0.005183983,0.05213577,0.046366606,0.047503147,-0.0010099158,0.07182927,-0.032193083,0.015990669,-0.09022637,-0.0054043545,-0.08337016,-0.003216782,-0.01963826,0.05878025,-0.05424045,0.037037555,-0.034030437,-0.062671565,-0.0077798734,-0.07509327,-0.066535205,-0.008529944,-0.005431282,0.011766102,-0.013352372,0.016846092,-0.06622347,0.007864875,0.06390994,0.14337331,-0.028152594 +3.4.21.25,"From the sarcocarp of the musk melon (Cucumis melo). In peptidase family S8 (subtilisin family). Other endopeptidases from plants, which are less well characterized but presumably of serine-type, include euphorbain from Euphorbia cerifera [6], solanain from horse-nettle Solanum elaeagnifolium [1], hurain from Hura crepitans [2] and tabernamontanain from Tabernamontana grandiflora [3].",384,0.9999999,0.024776835,0.009976892,-0.04735512,-0.05213681,0.077218965,0.062177595,-0.0003596484,0.039436463,0.041238613,0.00083140045,0.09027699,-0.12790848,-0.0725487,-0.026202882,-0.06296428,0.03733985,-0.047204416,0.016465545,-0.024185192,0.014657871,0.08162043,0.053649917,0.010348566,0.03790875,-0.060618315,-0.021277718,-0.05588721,-0.0738326,-0.051361248,-0.07949903,-0.02262861,-0.02729643,0.026675437,0.018583758,0.03934722,-0.032890737,0.0093340045,0.033502135,0.052185114,-0.016307479,0.05064441,0.026275164,-0.041451357,0.0070266672,-0.019522311,-0.0069652842,-0.0014067872,-0.025207577,0.02405079,0.02413612,-0.022880502,-0.07671317,-0.038190298,0.03300502,0.015009567,-0.001064305,-0.07608869,0.0036552409,0.03631073,0.01668958,0.07318079,-0.016986797,0.0015280627,-0.11424445,-0.044180967,0.0020812778,-0.028785788,-0.0702079,0.05467794,-0.0721455,0.03513458,-0.053048886,-0.06451263,0.06745388,-0.06626115,0.17701423,-0.058865447,0.005151178,-0.04371806,-0.04674186,-0.03766514,0.06518181,0.021748967,0.027501391,0.048124243,-0.0044864337,0.011756293,0.059507377,0.0066463905,0.031288784,0.02007736,-0.07065262,-0.003721733,-0.008656468,0.02241259,-0.033111993,0.05284688,-0.0522733,0.002353221,-0.0029833184,0.016669715,-0.023713969,0.0061281202,-0.07864086,-0.050249573,0.009298413,-0.05418805,-0.047278587,0.034481034,-0.10434971,-0.007130506,-0.0367012,-0.04542533,-0.052141458,0.04423944,-0.026278224,-0.062362913,-0.012230027,0.04790653,0.029339397,0.03929236,0.046719924,0.036481332,0.06828035,0.022344025,0.08023005,-0.11497949,7.1975534e-33,0.018039018,-0.013547751,0.051249914,0.0024480727,0.025203455,-0.012809678,-0.06455056,0.07188725,-0.008525588,-0.116927035,-0.14325462,-0.02453452,-0.039855856,-0.0044644824,-0.017374711,-0.01636929,-0.033074357,-0.00806831,0.031227931,-0.01603971,-0.03725559,0.09600025,-0.02055238,-0.05025402,0.0059214113,-0.016362084,-0.04333042,-0.05174782,0.06071326,0.017982425,0.059749693,-0.07117453,0.023904992,0.061425913,-0.017456654,0.058839127,0.03582951,-0.10000321,-0.026316276,0.019090576,0.028760592,0.015674923,0.024084441,0.04302186,0.04188428,-0.09485173,-0.022286,0.042501904,-0.00025567305,-0.0012693842,-0.03849651,-0.01855757,0.07475229,-0.013370682,-0.027287824,0.007249819,0.04277862,0.050297216,0.01875222,0.09149721,0.01040965,0.043939017,-0.067195095,-0.061839156,-0.006102938,0.014767396,-0.10121042,0.06814333,-0.024495233,0.03827164,-0.009901749,-0.012437039,0.014887317,0.039854903,0.04340965,-0.012200948,-0.040555347,0.06417943,-0.052365106,0.03136468,0.043129724,0.07880171,-0.0485144,-0.012610145,-0.07018351,0.05722239,-0.039283782,0.002228847,-0.040498175,0.068712495,0.019545007,0.020089822,-0.027025165,0.03332046,-0.05933387,-6.253785e-33,-0.0013671485,-0.059725594,-0.031486306,0.003479035,-0.03779494,0.10098354,-0.009796556,-0.008411442,-0.0031011663,-0.03741565,0.04867712,-0.06371963,0.105202205,-0.07242518,-0.03551756,-0.018820232,0.06313572,0.08842518,0.08396971,-0.07858322,-0.08660848,0.0055807945,-0.019127527,-0.05798729,0.1014564,0.004281166,-0.055712745,0.10369821,-0.08174168,-0.033427317,0.0057589114,-0.023223475,0.030791106,-0.04720897,-0.056136455,0.02970846,-0.115826905,-0.06322368,0.09380875,0.04420195,-0.012014771,-0.018415226,0.10608173,0.09973935,0.0708612,0.0041987263,-0.03350815,0.078318,0.026576864,0.036441237,0.03318306,-0.07075715,-2.5752057e-05,-0.037506822,0.062028304,-0.014556216,-0.002655818,0.048456993,-0.027707512,0.035054587,0.02903185,-0.03205761,-0.014877583,0.03624746,0.057531923,0.011845148,-0.09112395,0.028052023,-0.001172811,-0.023601538,0.06311208,-0.062170003,0.00885603,0.020021407,0.0033022112,0.0378867,0.022292495,0.012716489,0.042634826,-0.0714728,-0.070343554,-0.035138033,0.066177994,-0.037885327,0.06116553,0.002203605,-0.034297455,0.03696851,0.025554396,0.10946746,-0.058305852,0.033750996,0.017306903,0.053303733,0.10517822,-4.816291e-08,0.09334233,-0.032252233,0.038184814,-0.053438094,0.044335127,-0.03674554,0.034102328,0.039667085,-0.010752773,-0.05076213,0.021966875,-0.027827796,0.004139778,0.011058829,0.05341534,0.010091391,0.110932775,0.07955977,0.027973445,0.011523243,-0.12509415,0.013448824,-0.047786955,-0.037246812,-0.061890848,-0.05316829,0.022795778,0.046652377,0.008434051,0.0011399377,0.039504074,-0.017748687,-0.031779345,-0.12437326,-0.018098693,0.12904797,-0.070091344,-0.010828654,0.020731913,0.020670203,0.019362919,0.023502165,-0.039843183,-0.0291481,0.02415071,-0.031710044,0.06943476,0.042385384,-0.08266287,-0.038225133,0.021293325,-0.034570098,0.05027053,-0.020314485,-0.09302711,-0.06983528,0.034642853,-0.040190965,0.016072389,0.008467864,-0.030242598,0.0604232,0.13057867,0.093045264 +3.4.21.26,"Found in vertebrates, plants and Flavobacterium. Generally cytosolic, commonly activated by thiol compounds. Type example of peptidase family S9.",384,0.99999994,-0.024200797,-0.07377494,-0.12244993,-0.040062103,0.049783997,0.10738077,0.011647605,0.08543581,0.061012376,0.046967607,0.091139786,-0.041234866,-0.010057824,0.022719324,-0.025170213,0.020355409,0.012129531,-0.054971155,0.03080848,-0.079958715,0.008029766,0.07370129,0.03281312,0.032631826,-0.059474457,0.0056029684,-0.008771207,-0.017754054,0.008713157,-0.034362104,0.0007508711,0.03180672,0.13556719,-0.032113913,0.039404232,0.013117616,-0.04859746,0.024476666,0.06986024,-0.0074359914,0.066938035,-0.040521946,0.054198753,-0.044967804,0.022699272,-0.034021266,-0.020174462,0.07358864,0.055500057,-0.04540801,-0.0058330973,-0.0515444,-0.052698433,0.08766018,-0.04435626,0.016930975,-0.036467932,-0.016420282,0.019184338,-0.01893602,0.08553888,-0.000981502,0.023170734,-0.014509036,-0.045846153,0.018689102,-0.016507575,-0.017359713,0.06977482,-0.029035274,0.064300194,-0.0050026313,-0.057103742,0.1117994,-0.040860277,0.08694245,0.038228706,-0.058960196,-0.079842106,-0.04054467,-0.0015375632,-0.0035832408,0.08897897,0.053362,0.03993013,-0.0032380533,-0.012821546,0.039725482,-0.012193963,-0.013469321,0.052449014,-0.009232261,0.044152655,-0.07463389,-0.08923528,-0.01389139,0.06855906,-0.075016715,0.060576163,-0.010597028,0.07343841,-0.056137905,-0.023929676,-0.050098784,-0.025199039,0.11166151,-0.065350585,-0.032836907,0.072912805,-0.060444374,-0.0917044,0.0102633,-0.06697127,-0.07851884,-0.04167338,-0.04884139,0.010433849,-0.03879872,0.010627609,-0.04025077,0.010180227,0.040045317,0.03654707,0.012590718,0.010986458,0.007922902,-0.16046453,2.5972008e-33,0.029214114,-0.010159492,0.03455747,0.03677996,0.018310774,0.030022262,0.007135763,0.021349672,-0.01205989,-0.06864103,-0.109098874,0.0039680665,-0.027371777,-0.020372866,-0.014698935,0.011780204,-0.052104507,-0.04454377,0.07787151,-0.04070331,-0.03558286,0.08800155,-0.01820762,-0.06221033,0.026917953,0.0051378245,0.043969516,-0.028782662,0.064673625,0.007805969,-0.014465975,-0.03393769,-0.033338543,-0.017629141,-0.0053057913,0.053042836,0.011559371,-0.06492905,-0.015306068,0.026302285,0.026303502,-0.020097021,0.037681445,-0.047729496,0.06604131,-0.05813531,-0.09758308,0.024156079,-0.004864357,-0.004046829,0.016802981,-0.0707527,0.10745665,0.031019121,-0.052078903,0.010715337,0.0061595463,0.027089301,0.039681002,0.0823656,0.081687,0.013776131,-0.06302376,0.020879153,0.0048411977,0.020164153,-0.10558058,-0.009457058,-0.018159127,0.11868718,0.038446233,0.03038539,0.032592986,-0.030390382,0.054094847,-0.04633501,-0.032270875,0.069573104,-0.050595764,0.06568035,0.04248623,-0.0473776,0.0017843562,0.09414321,-0.033867776,0.039614014,0.033394355,-0.013520712,-0.07106794,0.02541893,0.02167967,-0.06619147,-0.038565658,0.020826971,-0.013299768,-3.172864e-33,0.06486494,-0.029109877,0.037824005,0.00017948715,0.0071181892,0.058871865,-0.023345185,-0.02306562,0.033057477,-0.037507925,0.012134444,-0.025100017,0.025668379,-0.11857235,0.02128848,-0.005272797,0.02172294,0.043062523,-0.029002942,-0.0016160287,-0.16351831,-0.044160273,-0.014040198,0.008079845,0.029312765,-0.04054627,-0.027000539,0.046328723,-0.008174152,-0.0028607838,-0.105118684,0.0553036,-0.05375474,-0.07446917,-0.03858788,0.025971724,-0.043683324,-0.0037823303,0.011502562,-0.027118828,-0.009782588,0.07315465,0.038685527,0.11206903,0.03504237,0.11464677,-0.057218477,0.057567805,-0.0078245,0.022174755,0.03563961,-0.098496735,-0.030260168,0.029739536,0.09001628,-0.0039653806,-0.042229604,0.026131637,-0.004194247,-0.03713614,-0.008569105,-0.016668437,-0.045178447,0.015133163,0.04165071,0.039463747,-0.13014755,0.037497208,0.009346829,0.00011136559,0.07979874,0.016502693,-0.010297536,-0.020999182,-0.020535247,0.08603472,-0.06133059,-0.0618577,0.023658521,0.04802201,0.056900583,-0.03658018,0.01274484,0.004614791,-0.023629721,-0.07551426,-0.0035599356,0.10804219,0.04778161,0.032113444,-0.01572919,0.038453177,-0.009364712,0.03491997,0.059194397,-2.925777e-08,0.027311126,-0.07835216,0.0023861125,-0.04338695,-0.029698173,-0.005869196,0.046889875,0.031975716,0.02725338,-0.07162945,-0.03703611,-0.00932213,0.030555401,0.009262879,0.045209393,0.034711167,0.040743038,0.039369762,0.0048670406,0.07258294,-0.13705319,0.035732932,-0.011650655,0.018918999,-0.060935017,-0.035565026,0.025439695,-0.052925374,0.018405877,-0.018583395,0.035073668,-0.010080414,-0.035112537,-0.03006732,0.03163095,0.026816627,-0.04360308,-0.025534807,-0.0135787595,-0.038359914,0.004935966,-0.005296478,-0.104895286,-0.031935554,-0.031097537,-0.04380114,-0.0065433667,0.11192952,-0.045967847,-0.048247844,-0.08056076,0.008555774,-0.013469492,-0.07504889,-0.09106374,-0.026407344,0.0748491,-0.06946268,0.022654658,-0.09521767,-0.0048015243,0.046483804,0.18944737,0.08361334 +3.4.21.27,"In peptidase family S1 (trypsin family), and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa",384,1.0,-0.046548426,-0.041920383,-0.066909224,-0.04269274,0.06842247,0.10980625,0.045204155,0.101487935,-0.0011716792,0.0018308767,0.08338415,-0.04824391,0.012697228,0.12101326,-0.05704228,-0.035211172,0.0034538899,-0.02325833,-0.010095634,-0.13367197,-0.06308839,0.0029592915,0.036008872,0.010135364,-0.04844427,-0.020744473,-0.018191349,-0.044004727,0.06590856,0.03504039,-0.025213322,-0.0118154725,-0.034681946,-0.032779623,0.033506487,0.00050826964,0.053971615,-0.049260486,-0.045193292,0.014877881,0.061995637,-0.07205078,-0.047774177,-0.051773373,0.019867718,-0.02594627,0.014258364,0.11280175,0.05793733,0.061791155,0.010873283,-0.036830112,0.03384369,-0.02180127,0.06823559,0.075189054,0.002192232,-0.037478887,0.03695767,0.04915347,-0.05662933,0.016569976,-0.004131337,0.003461026,0.04276304,-0.029044863,0.017310599,-0.03534948,-0.07735103,-0.018558389,0.011333178,-0.022189172,-0.13732883,0.09203739,-0.029911043,0.03722958,-0.061037447,-0.08089461,-0.039530892,-0.019085731,0.0060786647,-0.0007767783,0.07738103,0.117222,-0.030477874,-0.012246081,0.0032562688,0.057921577,-0.012363101,-0.0015739959,0.066336654,-0.0775598,0.08959311,0.028171293,0.010466648,0.04129108,-0.037589706,-0.09279448,0.024024658,-0.034683466,-0.02924955,-0.053793855,0.028141271,0.00909327,-0.04516642,0.026120104,-0.08943542,0.06803026,0.07384796,0.02725517,8.3111365e-05,-0.09535147,0.0819238,-0.058688067,0.013696791,0.030809142,0.033339914,0.026917323,-0.03111671,-0.06975357,0.06629257,0.054225683,-0.029645761,0.054730967,0.069302134,0.025333062,-0.021953655,3.3316618e-33,0.05581062,0.0065796883,0.042186223,0.06503791,-0.0465858,0.032693326,-0.03548315,0.018356217,0.009537402,0.009988312,-0.08113573,-0.06675181,-0.04477097,0.019158375,-0.056421414,0.018980727,-0.072603755,-0.08374701,0.021630157,0.060542524,-0.05596788,0.06816623,0.04679194,-0.0547187,0.058686066,0.036178514,-0.0069653974,0.024568478,0.019308038,-0.017398795,-0.075057365,-0.03153619,-0.10951263,-0.0068564406,-0.063703574,-0.03101525,0.07826242,-0.06737972,-0.026739582,0.07550332,0.069648586,0.028328056,-0.07919928,-0.06495595,0.06963658,-0.053951878,-0.0032614241,-0.014634034,0.008764368,0.049197435,0.049545757,-0.054051574,0.08760345,0.0067464043,-0.003949733,0.036002927,-0.02750099,0.025404187,0.035892025,0.03533545,0.02119539,-0.008167079,-0.022444451,0.053300593,-0.010732164,-0.006375441,-0.017391535,-0.09398451,-0.044585485,-0.048168033,-0.043333627,0.06728,0.07351601,0.00562981,0.043483954,-0.10454066,-0.006865127,0.116102494,0.0010639601,-0.0013587694,-0.03220618,0.014807394,0.0018669063,0.029986765,-0.029519908,-0.044178836,0.037269086,-0.0030568598,-0.1090479,-0.09321412,-0.005220515,-0.025730144,0.0060685473,0.10752727,-0.004741821,-4.670315e-33,0.035256825,-0.12261012,0.0724424,-0.057247277,0.020012818,0.040922686,0.07266168,-0.03710932,0.08910832,0.0071034473,0.05603661,-0.004755508,-0.01059966,-0.0032142305,0.040091276,0.007585032,-0.031934317,0.06207265,-0.09161687,-0.031861838,-0.073472306,0.034253288,0.057752583,0.029108675,0.06927461,-0.00024931112,-0.044221573,0.039122216,-0.033325016,0.024484513,-0.008521148,-0.031054636,-0.08995893,-0.07164915,0.027701188,-0.0025877086,-0.022001205,0.06239902,-0.001325193,-0.029380169,0.0020506452,0.08956254,0.07987777,0.007895223,0.0053504775,0.13943323,0.008461066,-0.05475535,-0.027955532,-0.05819087,-0.07459645,-0.050135,-0.01734184,0.10297642,0.0065920707,-0.014816025,0.05789312,0.06095774,-0.024674369,-0.0009310761,0.006155753,-0.003816253,0.022364842,0.005495835,0.041764326,0.0018873193,-0.04505259,-0.033926222,0.10635055,-0.023089994,0.05804117,-0.067364775,0.043974992,0.05695625,-0.021159174,0.017422356,-0.09530581,-0.01877046,0.02440924,-0.07441261,-0.018980963,-0.043061268,-0.06637609,0.0058620605,0.014262121,-0.038718678,0.0039843265,0.042494662,0.13163178,-0.024051331,-0.05125084,0.00643881,0.030404745,0.06634042,-0.0030125934,-3.4787973e-08,0.06797275,-0.059541967,-0.036670294,-0.07138879,-0.044797003,-0.050068963,-0.032057654,0.0233277,0.058644157,-0.035409905,0.02710787,0.018703109,-0.04133932,0.0149483,-0.0072173844,-0.005663441,0.0058357106,0.017410869,0.013007144,-0.0261314,-0.038695082,-0.042065885,0.036727145,-0.024793485,-0.03862205,-0.08939448,0.037144873,0.00508437,0.019783476,-0.067250185,-0.030114012,-0.007542737,-0.044297364,0.000121959754,0.040283553,0.059412595,0.039641,0.018233143,0.08452036,-0.018577522,0.027904438,-0.11446166,-0.016403278,-0.07830216,-0.0153580215,0.0031414772,0.039772026,-0.029636016,0.03549711,-0.004021389,-0.019135812,0.009151056,-0.066563964,-0.0670748,-0.045581233,-0.011329282,0.0060040713,-0.012233509,0.06138858,-0.11090237,0.047551155,0.06735312,0.14101967,0.0003743518 +3.4.21.32,"From hepatopancreas of the fiddler crab, Uca pugilator. In peptidase family S1 (trypsin family). Other serine endopeptidases that degrade collagen, but are not listed separately here, include a second endopeptidase from Uca pugilator [4], digestive enzymes from other decapod crustacea [5,6], and an enzyme from the fungus Entomophthora coronata [1].",384,1.0,-0.006879405,-0.0068145455,-0.030311642,-0.049888905,0.0075006383,0.008434882,-0.033371095,0.027645608,-0.0054082684,0.022803174,0.07120244,-0.04531842,-0.03886795,0.06258215,-0.13340814,-0.019001978,-0.050940827,-0.0036111323,0.05352129,-0.03986643,0.013105665,0.06666115,-0.052407317,-0.02570497,-0.0783034,-0.018378269,-0.042019892,-0.089216106,-0.03475174,-0.08941709,-0.02420621,-0.10641034,-0.030042995,-6.954416e-05,0.0875969,0.029207801,0.005609172,-0.023652945,0.039963715,0.06842724,0.019977584,0.021002302,-0.055339795,-0.003173845,-0.00048007217,-0.05513751,-0.01636265,-0.008345599,0.0365797,0.05253985,-0.04369288,-0.078724526,0.010954054,-0.034769267,0.041578546,0.010735844,-0.057827294,-0.045645528,0.012954371,0.02617525,0.011956557,0.037548043,0.026568145,-0.07551476,0.05754225,-0.0078420155,0.033740688,-0.024307948,-0.0022664177,0.034064323,-0.03073308,-0.044304326,-0.02740874,0.07325203,-0.016948234,0.050023984,-0.07285343,-0.00030082394,-0.019757818,-0.032553513,-0.040262517,0.014016526,0.0033312223,0.07558215,0.015352698,0.057918143,-0.019122342,0.01386736,0.008260343,0.040318035,0.05931914,-0.06972295,0.023072619,-0.04607111,0.021352097,-0.0044563334,-0.00024657923,-0.033572987,-0.013785073,-0.017953025,-0.054656263,-0.039050635,0.05640283,-0.12238353,-0.023057679,0.026877642,-0.05636185,0.0699543,0.1370184,-0.021262236,-0.053230546,0.02587605,-0.018430157,-0.03788176,0.037271038,0.078821056,0.019807994,-0.07371892,0.019086633,-0.022901587,0.01727366,0.010893087,0.053727604,0.05133211,0.016324762,0.034490705,-0.09947091,3.4901632e-33,0.038255047,-0.006291931,0.049837958,-0.021673273,0.017175067,-0.042406403,-0.038316123,0.047759656,-0.011630319,-0.031189645,-0.118930414,-0.036727034,-0.031869587,-0.02087902,0.02813292,0.017292835,-0.06757518,-0.0020864683,0.0036927802,-0.014988559,0.018142862,0.07441829,0.032901496,-0.083074756,0.031554945,0.04577556,-0.04846044,-0.0041733384,0.0416334,-0.004917929,0.013963084,-0.040954515,-0.013796841,-0.011522106,0.011871717,0.015912533,0.07122741,-0.026546076,-0.075145535,0.031288896,0.08299394,0.016240908,0.029626193,0.019202547,0.107740566,-0.14634289,-0.012973294,0.062510796,0.00621148,-0.029765556,0.083882906,0.02422717,0.01674943,-0.0467304,-0.07744366,0.021324953,0.027657097,0.04777502,-0.0075998334,0.053647358,0.09434123,0.014345147,-0.05426194,-0.056646492,0.017202213,-0.025312487,-0.03697958,0.07452025,-0.025833236,0.012253457,-0.06197555,0.0026710643,0.021231648,-0.0016160499,0.040461414,-0.024865566,-0.078112565,0.07068448,-0.014231618,-0.03421798,0.02086618,0.0032961979,-0.02866309,-0.0028663466,-0.05056,0.07417142,0.087834135,-0.03998995,-0.0106432205,0.038493372,0.021822033,-0.013048998,-0.032872614,0.050360646,-0.037021477,-4.6313397e-33,-0.029936343,-0.10434593,0.029734263,-0.01125226,-0.03455944,0.024171287,0.045577336,0.075006425,0.0073445737,-0.038797565,0.07090598,-0.052928653,0.06024191,-0.097603664,0.014539448,0.07139616,0.013639468,0.046454746,0.024329605,-0.109869055,-0.019615902,0.048144374,0.069576845,-0.018288773,0.051160082,0.05410068,0.022920126,0.09400699,-0.017030949,-0.0072014835,0.03983227,0.020682126,0.047828272,-0.035480052,-0.11319792,0.021888312,-0.14785248,-0.005423314,0.033062674,0.0054429574,0.06962294,-0.04391031,0.05728841,0.17787443,0.06541958,0.053802222,-0.064963534,0.0010685051,0.019947369,-0.02040285,0.027812703,-0.05386098,0.04781534,-0.02136622,0.07450747,0.04336068,0.036253083,0.0054140794,-0.0017665672,0.003530569,-0.01137594,0.029696887,-0.006713496,0.08907365,0.14080974,-0.001112456,-0.080673315,0.017971132,-0.06658837,-0.002428345,0.08054604,-0.04808067,-0.017400198,0.014563266,0.023613695,0.025128502,-0.061436877,0.021064298,0.022276781,-0.06520567,-0.13183838,-0.03761052,0.026225284,-0.0641541,0.038567863,-0.036268547,-0.0029853836,0.040332157,0.020246116,0.060932178,-0.026325002,-0.020182086,0.01119203,-0.018376427,0.003292924,-3.7657713e-08,0.052765064,-0.028227933,-0.013868297,-0.06868289,-0.03230897,-0.06524147,0.030467708,0.067232765,-0.003934518,-0.05691913,-0.029538468,0.022400152,-0.0026173715,-0.012423087,0.056118663,0.05436533,0.044977292,0.04299654,-0.0053561567,-0.09437795,-0.16272636,0.012213735,0.018548707,0.0021007839,-0.079577886,-0.0046727173,0.035819784,0.10190583,-0.026658062,-0.011204951,-0.041975837,-0.010680842,-0.0024547249,-0.09562007,0.024432356,0.10291607,-0.027960477,-0.06706292,0.020312643,0.06483978,-0.0010571727,-0.05480966,-0.04817088,-0.031312425,0.0018555907,-0.0053507867,0.08380998,0.03946783,0.042996943,-0.06772534,0.036838286,-0.069081336,-0.044247366,-0.07843562,-0.113838434,-0.012994784,0.04246198,-0.04545226,-0.018487498,-0.031790897,0.034455247,0.009779283,0.16336934,0.121306 +3.4.21.34,"Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates.",384,1.0,-0.04835025,-0.13558307,-0.072598375,0.021702945,0.097678244,0.06486221,0.009805638,0.07993713,0.02424938,-0.009966411,0.04006677,-0.017851656,-0.047474857,0.03532783,-0.036695365,0.029895272,-0.019266173,-0.016362214,-0.033737134,-0.09047046,-0.029772026,-0.034105636,0.03897981,-0.02406631,-0.0030865162,-0.016198104,0.023266967,0.05603152,0.09528316,-0.030318312,0.023893813,0.05425689,-0.031300746,-0.020417303,-0.010135957,0.10622628,-0.08189344,-0.060800456,-0.047023095,0.044604704,0.14299172,-0.0814495,-0.045655645,-0.04522051,0.02090109,-0.010901946,0.0029287785,0.061100896,0.010628668,0.102715045,0.0042093303,0.008126204,-0.06456264,0.044185482,0.0011568456,-0.032902222,-0.00401908,0.042410053,0.00962311,-0.018860346,-0.069670565,0.054531295,-0.0077335006,0.026012424,0.017586263,-0.013551869,0.02801436,-0.015184763,-0.026151737,-0.037552383,-0.04418033,0.005163857,-0.0056338985,0.065612994,0.040080726,0.0429114,-0.0955678,-0.076309204,-0.053805124,-0.0066119605,0.055502776,0.043428387,0.05404168,0.14739698,-0.08689547,0.042768367,-0.0067600114,-0.026997443,-0.0145124495,-0.031253178,0.121572606,-0.032056473,0.06337844,0.03509387,-0.050870094,0.09618278,0.0038987726,-0.075330995,0.02588599,-0.018964943,-0.04978484,0.0047731013,-0.058597,-0.0072124735,-0.10576622,-0.00850122,-0.031673536,0.046202134,0.010948917,0.027564071,0.012704951,-0.056676056,0.064988956,-0.05615776,0.040926624,0.06414375,0.06005471,0.025092361,0.00786149,-0.028204208,-0.015840372,0.03222468,0.033787414,0.047358397,0.022635162,0.066692114,-0.039561227,3.248661e-33,0.10674926,0.009437321,0.08221412,-0.031616867,-0.050108206,-0.04504821,-0.060873944,-0.07305127,-0.034752473,0.027596088,-0.044972003,0.017047906,-0.009132193,-0.022720814,0.045806017,-0.025333105,-0.017406752,-0.028612617,0.04766585,0.0003970377,-0.0058979797,-0.008663562,-0.014549365,-0.03330775,-0.017296536,0.036349367,0.04774218,0.047801986,-0.026195677,-0.006595187,-0.108009525,-0.038092155,-0.10976265,-0.007290963,-0.058196146,-0.06420434,-0.060906544,-0.073742785,-0.0007918007,0.080676824,0.048059035,0.0005607519,-0.029230265,-0.05794713,0.044412073,-0.10462891,-0.03490716,0.06902894,0.019424576,0.035865773,0.088193715,-0.057769567,0.19527498,-0.0070057977,-0.02680007,-0.008033742,-0.0073017315,-0.008329894,0.030601041,-0.036841404,0.030585071,-0.0592942,-0.019725192,0.082490005,-0.002922341,-0.006191657,-0.028393827,-0.002450674,-0.0055767517,-0.04375522,-0.045100033,0.028275838,0.014555774,-0.00023572077,0.048568655,-0.05437142,-0.027428862,0.11326995,0.016954122,-0.004907195,-0.039902914,0.042399753,-0.015907532,0.049350247,-0.024329826,-0.07700027,0.0040328475,-0.01647059,-0.039123133,-0.041163523,0.002969707,0.0126636205,-0.002306072,0.051071655,-0.011118632,-2.7729745e-33,0.041456547,-0.05314886,0.064736985,-0.008434836,-0.020187644,-0.018525004,0.04655177,-0.026259167,0.09541726,0.03278252,0.044253863,0.023868877,0.0027484575,-0.0018655199,-0.00047223872,0.017033566,-0.025916332,0.101601414,-0.015042281,-0.040419746,-0.034900803,-0.037886046,0.084107235,0.018926527,0.04611192,-0.017399354,0.01930586,0.05330405,-0.06302088,0.09670103,-0.007837824,-0.014394214,-0.09213437,-0.07460726,-0.06259588,-0.03826646,0.042876337,0.029437589,-0.0034648657,-0.076988675,0.003236298,0.05092076,0.09475111,-0.0028504354,0.023498753,0.047859713,0.11004663,-0.024097532,0.039962985,-0.081015006,-0.07510474,0.0057609156,0.008677986,0.03544468,-0.03354421,0.06133923,0.059518266,0.047496956,0.044736497,-0.037336014,0.03627402,-0.025380904,0.044867966,-0.01103226,0.035851493,0.0449243,0.08264494,0.062138446,0.07303295,-0.061767444,0.12421707,-0.009328615,0.053642556,0.08737998,0.0364268,0.019382328,0.0017993934,0.024708984,-0.004514874,-0.0086791,0.012269847,-0.0654953,-0.13848598,-0.103649914,-0.03515657,0.0046948115,0.0530909,0.026592094,0.0072702663,-0.046608552,-0.010817144,0.023668714,7.5336234e-06,0.08013624,0.024476325,-2.929151e-08,0.030735455,-0.06870396,-0.03997878,-0.05673982,-0.012397429,-0.010515867,-0.016746808,-0.03701712,-0.001291887,-0.06482799,0.023270724,0.016938208,-0.0006567301,0.019900646,0.10313656,0.014134624,-0.005348602,0.034438033,-0.070139445,-0.06302811,0.032295838,-0.07199135,0.03388946,0.010404405,-0.03378462,-0.06127691,0.03084341,-0.019426772,0.06516677,-0.032839905,0.0031924453,-0.0032736396,0.0064890003,-0.051302284,-0.0009396744,0.115970396,0.04106515,-0.0065700016,0.020145135,0.017465772,-0.0535129,-0.08838417,-0.042564567,-0.08479962,-0.042591013,0.05439513,0.027332725,0.017404862,0.0154013885,-0.046911135,0.0037796907,-0.05779167,0.012280784,-0.09401018,-0.067655385,0.01745931,0.026766255,-0.0056344713,0.06513173,-0.15953559,0.016612386,0.027563307,0.09812568,0.020966385 +3.4.21.35,"Formed from tissue prokallikrein by activation with trypsin. In peptidase family S1 (trypsin family). A large number of tissue kallikrein-related sequences have been reported for rats [16] and mice [7], though fewer seem to exist in other mammals. The few that have been isolated and tested on substrates include mouse gamma-renin (EC 3.4.21.54), submandibular proteinase A [2,15], epidermal growth-factor-binding protein, nerve growth factor gamma-subunit, rat tonin [3,4,9], submaxillary proteinases A and B [10], T-kininogenase [18], kallikreins k7 and k8 [17] and human prostate-specific antigen (gamma-seminoprotein, [6])",384,1.0,-0.06261275,-0.07840082,-0.072136104,-0.042586118,0.031298008,0.07654518,0.017554944,0.08035087,0.023766473,0.07451699,0.041748766,-0.009310114,0.019216605,0.16729161,-0.03747994,-0.0062307296,-0.04564009,-0.029594768,0.015019545,-0.08408441,-0.037100397,-0.0020191462,0.04129171,-0.011385876,-0.028053932,-0.07493816,0.041026995,-0.001745296,-0.037251607,0.04623904,-0.03092988,-0.099559836,-0.077596456,-0.050626177,0.059625253,0.012935876,-0.15069759,0.012080865,0.048836567,0.01938391,0.0411807,-0.08736449,-0.079031974,-0.0060051167,0.0133812465,-0.02300535,0.00033779826,0.041604906,0.031716157,0.034104016,-0.023442497,-0.03759229,0.045376424,0.054968968,0.045604102,-0.051169463,-0.097996175,0.03418375,0.056627665,0.0808006,-0.052490972,-0.052716907,0.07781024,-0.047987435,0.030928865,0.011190613,-0.013698908,-0.0017596262,-0.048503596,0.015548378,0.03741762,0.003726345,-0.030023811,0.1264585,-0.001515745,-0.036589425,-0.10076148,0.04646831,-0.06840492,-0.08852969,0.017879535,-0.0035337755,0.041650187,0.05684754,-0.018986557,-0.034889676,0.060385145,0.08043637,-0.058250416,0.018287487,0.07942899,-0.04597821,0.023214204,-0.02742644,-0.017562492,0.015663624,-0.04271712,-0.014875323,0.009473528,-0.026500268,-0.03313796,-0.020553285,0.031018663,-0.06918437,-0.0047018453,0.011151571,-0.1142017,-0.004060933,0.046011224,-0.0029698212,0.043328762,-0.037250463,0.017370047,0.007866009,0.087746695,-0.016624397,0.036200415,0.019714694,-0.016020536,0.067037284,0.03751517,0.06852041,0.035573293,0.105093844,0.031496353,0.067589134,-0.02830791,3.6959237e-34,0.07338603,-0.007491809,0.001241114,-0.0020188233,-0.012134077,0.0053824736,-0.05108452,0.029118573,-0.056250427,-0.036882315,-0.072673395,-0.067442276,0.047427554,-0.03692381,0.0012211398,0.07657182,-0.035455186,-0.01733811,0.05092045,-0.007433823,-0.040383942,0.052327614,-0.008993601,0.007008795,-0.03786474,0.05357485,-0.049580555,0.0059434194,0.045639798,-0.031132275,-0.065721415,-0.021848397,-0.0794317,0.02104859,-0.036930338,-0.0068552746,0.0256963,-0.05417743,-0.025239268,-0.019297812,0.06212977,0.004550038,-0.047580667,-0.06863762,0.02504136,-0.026425874,-0.018914197,-0.02155073,-0.046461564,0.017457675,0.055007927,-0.05558891,0.07910576,0.029912625,-0.065888435,0.0030738118,-0.00015004998,-0.0076226243,0.053967252,0.011106129,-0.004684291,-0.0849886,0.017390013,0.02669921,-0.04184229,-0.033503823,-0.045592286,-0.037296593,-0.06724218,0.016164254,0.0052808635,0.05450874,0.058666494,-0.06824215,0.02538831,-0.02016294,-0.0018973879,0.1066084,-0.08500734,0.116174646,-0.05159109,0.020022172,-0.021791713,0.026749473,-0.026032804,-0.06537979,0.017191155,-0.026871841,0.005359473,-0.044398088,-0.008507374,-0.0131455595,-0.12204309,0.09412008,-0.024264956,-2.5569952e-33,0.09424596,-0.062241845,0.14558211,-0.010434149,-0.027075015,0.07901304,0.07293181,0.01414854,0.02545869,-0.032987293,0.092809126,-0.077479206,0.019106733,0.013756501,-0.01825455,0.017046332,-0.055376858,0.1561588,-0.015090083,-0.07444269,-0.076554604,0.03176825,0.008679021,0.07484416,0.05276838,0.038549762,-0.059003334,0.021020174,-0.03902697,0.10226958,0.020483855,-0.0066411104,-0.11215072,-0.05999451,0.05507965,-0.033058893,0.0037011139,-0.016998347,0.035741597,-0.011113383,0.06444138,0.108007364,0.10408083,0.048973262,0.00200941,0.08455714,0.07091712,0.036531404,-0.011840234,-0.048438583,-0.03964226,-0.019629562,-0.06403614,-0.0063724667,-0.016106239,0.03907922,0.06715257,0.06060265,-0.017616259,0.017185021,-0.052553374,-0.08963368,0.009486518,0.054984137,-0.037220642,0.027450962,-0.015888408,0.00018538808,0.050098322,-0.024258368,0.04771072,-0.07507475,0.08478981,0.055309452,0.010979635,0.017902326,-0.005161316,0.03225953,0.015830107,-0.05260517,-0.024222877,-0.026703903,-0.061964475,-0.0014929585,-0.0065606446,-0.01781769,0.0055920244,0.050206337,0.061963744,-0.059192974,-0.040823117,0.051039178,-0.013586795,0.05169246,0.06888659,-4.6956252e-08,0.08593779,-0.058495883,0.0026661681,-0.054776136,0.0140442895,-0.023657175,0.009182999,0.04397431,-0.005792482,-0.06955097,-0.0025337818,-0.022492232,-0.07542916,0.049092796,0.00492872,0.023629637,0.026889458,0.037816662,0.010247448,-0.033988543,-0.045142688,-0.06963245,0.032268256,-0.028545031,-0.061894335,-0.027108295,-0.036501043,0.061276056,-0.061604463,-0.11844082,0.066391684,0.01623485,-0.051716655,0.020044586,0.04696737,0.041953526,-0.0005313579,0.008347234,0.020504631,0.054523654,-0.07427756,-0.105706245,-0.067564614,-0.074521445,-0.04855043,-0.003642812,-0.008579347,0.04988367,0.0040122294,-0.05909916,-0.014389771,-0.011048352,-0.02755219,-0.07605949,-0.0027764256,0.02779994,0.040197298,-0.046330415,0.049358133,-0.087628976,0.039226994,0.049330678,0.08731729,0.025602248 +3.4.21.36,Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11,384,0.99999994,-0.05635972,-0.012336104,-0.1137421,-0.017939966,0.01947247,0.077826455,0.028496718,0.07698773,0.044456985,0.052120775,0.0591331,-0.06983572,-0.079878315,0.10409662,-0.069806606,-0.057962168,-0.05256251,-0.061958477,0.026415383,-0.0838358,0.033671368,0.04906758,0.03983323,0.08850726,-0.046854712,-0.03643838,0.06746986,-0.021563591,-0.015810845,0.003357422,-0.097728394,-0.14215636,0.06810042,-0.025894914,0.022707725,0.024009883,0.014092198,-0.012999862,0.005920975,-0.01121754,0.09193606,-0.040945046,-0.024730464,-0.02658216,0.029666986,0.022801941,0.050705742,0.058314227,0.06722992,0.051362053,-0.053193923,-0.050823037,0.042610098,-0.015385747,0.07535128,0.016309204,-0.014074012,-0.05290054,0.007054269,0.01338819,-0.060352407,-0.0073813554,0.04266151,-0.010648223,0.070310324,-0.020435637,-0.0028942665,-0.018047132,-0.053800337,-0.0061212922,-0.023439027,-0.009207124,-0.02363616,0.095927276,-0.055383522,0.1057886,-0.0075072837,-0.027144635,-0.0670035,-0.0457896,0.0052279904,-0.017173206,0.03137558,0.061367713,-0.02838073,-0.007146638,0.005820892,0.0064198445,-0.01633831,-0.08931975,0.044347268,-0.088801935,0.001342455,-0.024833776,0.0065524722,-0.0024644413,-0.06158337,-0.13256095,0.03668248,-0.016082691,-0.003440786,-0.00042578817,0.0024530175,-0.114117734,-0.006555199,0.10061919,-0.035062358,0.04223321,0.07648144,0.07321038,0.045319885,-0.024726482,0.06991401,0.033843163,0.02714066,0.10678269,-0.03897075,-0.0014043774,-0.00056461996,0.011399649,-0.019618772,0.0010706494,0.015738647,0.06526824,-0.02781817,0.047567785,-0.018501418,8.09358e-34,0.05471896,-0.0509844,-0.0022260696,0.084899925,0.0054029394,-0.00043079926,-0.025897687,0.004175651,-0.014687999,-0.08047606,-0.11306165,-0.087978475,-0.0065849335,-0.010909393,-0.053009197,0.0063997204,-0.03481357,-0.051387258,0.0822018,0.0132032065,-0.058253903,0.08077953,0.07121063,-0.13074556,0.04857867,0.07648581,-0.050246317,0.0098110195,-0.0038689233,-0.033745475,0.00010772252,0.025299037,-0.07577943,0.052540623,-0.02755286,0.017563613,0.096069746,-0.08268646,-0.046288174,0.07884734,0.04602263,-0.035107847,-0.036823858,-0.030433996,0.09476202,-0.041807797,-0.045710392,0.017127125,0.06597936,0.047246404,0.025656369,-0.03568707,0.04857274,0.014862675,-0.058409482,-0.055015765,-0.02892469,-0.020405084,0.10935858,0.03377111,0.025428662,0.06081565,-0.018231357,0.008406958,0.008562141,0.045984037,-0.044497944,-0.013091919,-0.016363446,0.0076507875,-0.009354476,0.04399936,0.10578584,-0.019408675,-0.013303638,-0.068229,-0.03541632,0.06208334,-0.019927528,0.051381897,0.05411369,-0.028359989,-0.014177956,0.025297167,-0.05938091,0.018884255,0.043823138,-0.0007687262,-0.05108813,-0.012097107,-0.013093688,0.03564494,-0.033483703,0.055921942,0.029152261,-2.4411085e-33,0.024587559,-0.0969306,0.0884328,-0.023636838,-0.050083216,0.0040964233,-0.0034736898,-0.061528776,0.00045494514,-0.032600876,0.039311398,-0.09826814,0.12573381,-0.08805853,0.023926446,-0.014525827,-0.07629891,0.056569997,-0.023102587,-0.0635686,-0.044100437,0.0272244,-0.029365499,0.061901893,0.124396496,0.029659878,0.00309138,0.07421918,-0.04187528,-0.011830444,-0.024802849,0.047087763,-0.12935399,-0.038745333,0.009431168,0.0043663746,-0.09047255,0.03214703,0.04410936,-0.07251892,0.0007558065,0.054467168,0.07643916,0.049134575,-0.041648917,0.080736615,0.023017874,-0.0245241,0.016764713,-0.06762885,-0.011986141,-0.06061075,-0.03764956,0.0047924737,0.07890556,0.033251118,-0.02057305,0.020562585,0.007034532,-0.016429663,-0.02687695,-0.03211415,0.03142364,0.01989718,0.065066494,0.0033684652,-0.059834212,-0.046995226,0.05846379,0.090364285,0.06391526,-0.04923804,0.076425724,0.03416044,-0.031061364,0.06171933,-0.06802674,-0.026727237,0.009246529,-0.04464165,-0.0075779287,-0.06443119,-0.0033312326,-0.02509523,-0.023302209,-0.017739242,-0.0078067435,0.056448337,0.027928097,0.018982112,-0.02552806,0.02228224,0.014988965,-0.0364302,0.033781745,-3.028067e-08,0.10369623,-0.06116475,0.03324132,-0.016645683,-0.035907067,-0.0072395205,0.012003043,0.025558373,0.04898813,-0.08868877,-0.059489828,-0.016938372,0.0017636835,-0.04281692,0.026059285,0.05542052,-0.032722913,0.06815871,0.00890264,0.009638415,-0.06832322,-0.06532125,-0.06332029,-0.038015705,-0.082020715,-0.043512993,0.012064822,0.08852144,-0.0037416492,-0.11083573,-0.018696059,-0.060908724,0.0065663825,0.03351579,0.077909805,0.09607246,0.018379904,0.032035574,-0.012258709,-0.03423847,-0.0070189666,-0.08776954,-0.025894197,-0.05170272,-0.09092446,0.02043761,0.0075753555,0.062758096,-0.028049864,-0.045081224,-0.024072567,-0.016245788,-0.014585616,0.0012104635,-0.02170663,0.014523875,0.00797291,-0.029607382,-0.0034784323,0.05250622,0.005833856,0.06152063,0.13258052,0.061470337 +3.4.21.37,Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11,384,1.0,-0.002963879,-0.07407036,-0.08789793,-0.057945617,0.07484983,0.08407864,-0.039808,0.118069075,0.047341388,-0.009262834,0.011414701,-0.034850143,0.013087007,0.083825335,-0.07770295,-0.07738203,-0.023027023,-0.079693794,0.06941541,-0.122079745,0.05479763,0.06287321,0.059129737,0.05133447,-0.046519246,-0.06557361,-0.018088993,-0.009517756,-0.040479545,-0.040067375,-0.106442906,-0.07389037,0.08823275,-0.05419054,0.0069828983,-0.0013658528,-0.008229876,0.018329035,0.004920783,-0.012470127,0.13568594,-0.0248555,-0.024349837,-0.081979476,0.0372989,-0.04560209,-0.013606171,0.0025072116,0.018508743,0.078674376,-0.044020653,-0.08476264,0.02572935,-0.002279722,0.04121034,-0.0063991244,-0.04156786,-0.011396002,0.054436054,0.05137072,-0.025909582,0.018851312,0.081582345,-0.012329865,0.08109661,-0.036848463,0.07463308,-0.037984487,-0.03843985,0.010515783,-0.060007315,-0.032988504,-0.06359431,0.112522185,-0.021509774,0.0295435,0.0046826024,-0.01159979,-0.085312776,-0.031675015,-0.031569973,-0.01801486,-0.01090508,0.04645475,-0.03609144,0.032376137,0.022443589,-0.0044376287,0.005810388,-0.0782106,0.09454755,-0.11639397,-0.0010043898,-0.0115125775,-0.014788759,-0.02100098,-0.08634044,-0.045695387,0.010543392,-0.036027003,0.07541588,0.013337077,-0.00039139137,-0.07257709,-0.0038930764,0.039592683,-0.02914592,-0.0026223448,0.032905415,0.003361064,0.051625405,-0.025190137,0.12171131,-0.0037647183,0.00032382656,0.07806573,0.012610803,-0.028716685,0.007453669,0.018666847,0.06825557,-0.03513867,0.04320186,0.048624586,-0.02367093,0.06995377,-0.07769196,7.514784e-35,0.029685989,-0.041634858,0.02016473,0.053411108,-0.025548104,-0.0145749105,-0.024267051,0.061212134,-0.04262493,-0.044013977,-0.088227585,-0.04688462,0.008487535,0.059427477,-0.037222207,0.060932085,0.029950878,-0.06167882,0.0076994095,-0.044437557,-0.05600028,0.059398558,0.018080106,-0.07870718,0.080473825,0.052831486,-0.019647367,0.017672408,0.07752957,-0.03777173,-0.017417211,0.04205284,-0.06384045,0.07241193,-0.0062037013,-0.0055121123,0.087031834,-0.06377183,0.01507602,0.027320027,0.042427875,0.053797685,0.009509633,-0.03316906,0.10097476,-0.013753663,-0.04887023,0.021686386,0.043570187,0.031177634,0.055750858,-0.033311717,0.043386124,-0.01619567,-0.008661124,0.027335918,-0.036145777,0.0057042665,0.10649507,0.0563821,0.01401775,0.04257137,0.010060704,0.012317083,-0.05380111,0.11583082,-0.050094996,-0.066169076,-0.035329383,0.04057681,-0.05787314,0.0151515035,0.056268778,0.04111033,0.07384276,-0.1163831,-0.05538694,0.017649056,0.023176895,0.038096216,0.00882884,0.0065206965,-0.053474665,0.01693265,-0.07440754,-0.079584114,0.017604198,0.036740676,-0.04017896,0.031024188,0.0065731243,0.05043311,-0.034997143,0.109418064,-0.022583956,-1.6189902e-33,-0.006691877,-0.095467746,0.087594405,-0.043147087,-0.046420164,0.009199425,0.035274904,-0.03892451,0.07375347,-0.049128663,0.05265505,-0.07090689,0.06478451,-0.07090898,0.024988469,0.013023096,-0.10401837,0.028786214,-0.037791956,-0.019332249,-0.051159777,0.016051272,0.010816419,0.06974039,0.058420938,0.0377327,-0.034279447,0.078473516,-0.02524023,-0.0380998,-0.049253814,-0.014670036,-0.12971543,-0.021492945,-0.07249807,0.005664108,-0.0446106,0.0054175733,-0.023954747,-0.075378515,0.022880083,0.09904232,0.08505767,0.058019232,0.0008921005,0.034179024,-0.01214701,-0.029714994,0.01575293,-0.06358304,-0.017003193,-0.020489255,-0.005942361,0.01659207,0.07319268,-0.008103467,0.012214793,0.010653093,-0.07228705,-0.0067175473,-0.046599995,-0.008232334,0.018894983,0.018972723,0.072608866,0.05306362,-0.05352879,-0.0022079782,0.057117898,0.045454342,0.07643568,-0.0640197,0.053189017,-0.02149023,-0.029081186,0.056474883,-0.08714305,-0.05367922,-0.014898356,-0.06478291,0.0044917655,-0.009661292,-0.0022016685,-0.032076824,-0.07247113,0.024428615,0.011053162,0.060567945,0.060247302,0.027096538,0.0029166576,-0.042558663,-0.015592722,0.010063192,0.040705927,-3.197568e-08,0.10324948,-0.04222567,0.052503232,-0.06288911,-0.070473604,-0.022482276,0.009957383,-0.001687279,0.028461872,-0.042024985,-0.06607649,0.011349003,0.009922585,-0.039890822,0.032181647,0.0475094,-0.046655614,0.11246743,-0.0029307182,0.078454524,-0.029580897,0.0057009617,-0.07459887,-0.026851375,-0.020624546,-0.051974244,-0.00713634,0.10021186,-0.018140504,-0.057492882,-0.039096147,-0.028132439,0.002084498,0.060977217,0.005983009,-0.0010630648,0.012375596,0.0030212589,-0.028286943,0.029335074,0.04947436,-0.11161719,-0.042308062,-0.07396635,-0.07752756,-0.008112627,0.06352269,0.0037878384,0.003955496,0.0070318077,-0.004680989,-0.008120474,-0.01804801,-0.046079896,0.0021765397,-0.042440597,-0.01007184,-0.054953385,0.018897397,0.020023897,0.02369563,-0.015213715,0.18061797,0.076570794 +3.4.21.38,"Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family)",384,1.0,-0.059315253,-0.07879809,-0.09724145,-0.0196544,0.05242246,0.11044564,0.044004615,0.109290965,0.04605309,0.03493036,0.050419807,-0.015099757,0.02193994,0.070076615,-0.029304711,0.0039154943,-0.019589562,0.0066992943,-0.000108363565,-0.13953227,0.009021736,-0.029418977,0.011206577,-0.02378639,-0.018569427,0.0049143396,-0.020384047,-0.0016436336,0.09962855,0.02684153,-0.027282549,0.02626164,-0.019359479,-0.053920757,0.0109043,0.051045433,-0.025369762,0.02382443,-0.005296198,0.047525875,0.06524408,-0.05525054,-0.05907365,-0.056788597,0.0001458178,-0.020632168,-0.004295976,0.11772469,0.04578948,0.058180846,-0.015127986,-0.057725526,-0.0025891247,0.022942826,0.06350958,0.017007539,-0.02543,0.028843354,0.03333617,0.03767985,-0.07408651,0.017596383,0.026221322,0.017755762,0.020302791,-0.028589293,-0.017453438,-0.020258045,-0.050652277,-0.04188606,0.034497295,-0.026574252,-0.04615034,0.042087995,0.024641981,0.0048143,-0.071092896,-0.054517068,-0.08382491,-0.024920868,0.018723985,0.015907768,0.04913644,0.10906524,-0.038530786,0.004486056,0.01987389,-0.0057393024,-0.0068192594,-0.015624561,0.09730263,-0.09704842,0.030042086,-0.009544051,-0.024886036,0.044596806,-0.0587098,-0.08743211,0.047072288,-0.035008796,-0.02752656,-0.08425318,-0.014127413,-0.056164753,-0.0715211,0.013483407,-0.04372582,0.045509532,0.055263575,0.032431256,0.0009801349,-0.05105962,0.043314848,-0.033815693,0.020129789,0.04631696,0.03687453,-0.0070838775,-0.018920755,-0.059071865,0.04269725,0.01664387,-0.00040409405,0.06856662,0.009212944,0.055958144,-0.03424612,3.4192963e-33,0.036831133,0.00395239,0.027677106,0.030408468,-0.010575907,0.014389508,-0.014670258,-0.040298637,0.025889296,-0.033317726,-0.111107595,-0.0046371124,-0.0020016916,-0.021925228,-0.028017726,-0.024530984,-0.072550185,-0.068122,0.05574987,0.041264255,0.014725219,0.057281736,0.007492763,-0.03960015,0.021129211,0.05004954,0.01602476,0.026383035,0.0035455471,-0.025688011,-0.06154507,-0.050612785,-0.12133811,-0.04046355,-0.04655287,0.026764778,0.06449081,-0.0723746,-0.03433372,0.05721344,0.02311833,0.00043372795,-0.07479351,-0.0364603,0.07706806,-0.0588368,-0.05307764,0.025072131,0.018795865,0.041538283,0.057995077,-0.0729327,0.12994389,0.024334267,-0.05447747,0.028291022,-0.0200206,-0.040603362,0.035507873,0.038081236,0.03435581,-0.06116743,-0.018529281,0.046501484,-0.0137612205,-0.018318351,-0.010278436,-0.060522247,-0.022903563,-0.006369692,-0.06714275,0.059593625,0.03117049,0.00848055,0.034309987,-0.081052236,-0.031477477,0.12243695,0.0010828509,0.050387144,-0.0028472203,-0.027749347,0.008339728,0.025444271,-0.030563135,-0.049174126,-0.02258922,-0.04140843,-0.095578775,-0.066370964,0.0021152836,-0.0049684774,-0.02741956,0.11780872,-0.023606714,-4.9301754e-33,0.027678229,-0.10458625,0.10624614,-0.0042677703,-0.004256894,0.06020765,0.049988158,-0.0068749264,0.05934127,0.016520534,0.021539751,-0.05690014,-0.01859199,-0.003076494,-0.030257948,-0.010720659,-0.045355383,0.15420029,-0.06234653,-0.036549047,-0.09979091,0.026589833,0.027148318,0.058806047,0.066117845,0.009650299,-0.03605691,0.0705121,-0.056660272,0.080593,0.0035498429,-0.035356212,-0.13998304,-0.041520543,-0.016031383,-0.02093218,0.00019959552,0.037275475,-0.01493701,-0.050322123,0.030991666,0.09744434,0.11752354,0.084488966,0.0011535815,0.10074312,0.03469396,0.019112267,-0.01851743,-0.10030835,-0.013120412,-0.04389971,-0.029329767,0.07459619,0.026932498,0.009075332,0.045174867,0.05196256,-0.0016394767,0.010227346,-0.00070241553,-0.048362486,-0.0007598306,0.033032723,0.049927436,0.008088357,-0.007122601,0.01026269,0.09968183,-0.017005805,0.10084203,-0.055012755,-0.009031031,0.06597881,-0.027701117,0.042454593,-0.07339858,-0.026053458,-0.008265453,-0.05038393,-0.0076459474,-0.07729564,-0.06566822,-0.04431419,-0.030002361,-0.015367039,0.05265089,0.037277374,0.06246465,-0.01895447,-0.05592517,0.029551545,0.007913912,0.071577266,0.04604697,-3.290565e-08,0.058183845,-0.049627136,0.012425139,-0.065162525,-0.04975787,-0.05780815,0.015243403,0.009442028,0.029174566,-0.101112366,-0.026709085,0.022040993,-0.024757903,-0.0053571747,0.1010956,0.051262144,0.03313199,0.07714701,-0.006359758,-0.03404021,-0.019354023,-0.05631047,0.021265304,0.00410914,-0.04676222,-0.06367368,0.0327034,0.05121176,0.073297895,-0.04837605,-0.010715941,-0.026602253,-0.014653513,-0.0446087,0.020838862,0.113469586,0.036236078,-0.0015695055,0.04511432,-0.00046156452,-0.054753162,-0.10802469,-0.02262767,-0.088550515,-0.07130852,0.013881503,0.028361022,0.036067236,0.01615182,-0.048305906,-0.0039522266,-0.042355176,-0.019299358,-0.08567617,-0.10614451,0.006253835,-0.0046932497,-0.03970599,0.073270135,-0.12709488,0.034663673,0.08607403,0.16041617,0.06201962 +3.4.21.39,In mast cell granules. In peptidase family S1 (trypsin family),384,1.0,-0.031045388,-0.026450567,-0.05435891,-0.013160501,0.010410537,0.06048753,0.049164463,0.09944023,0.013054418,0.058902062,0.07303463,-0.049428795,-0.0066922572,0.12681565,-0.052915785,-0.046185236,0.01907341,-0.05158583,0.01153671,-0.07595901,0.07374339,0.046495765,0.025635632,-0.00054084323,-0.05774506,-0.068981886,-0.059347335,-0.0073978896,0.011500285,-0.01583655,-0.07617742,-0.04030904,-0.0060221087,-0.043154493,0.0023138528,0.014743328,0.031353083,0.011772726,0.05214467,0.017166968,0.08430771,0.017259533,0.028227042,-0.026073975,0.009370097,0.048790697,0.012101172,0.104250036,0.12183725,-0.012043745,-0.020287596,-0.081329994,0.08209127,-0.017685656,0.05075044,0.05281917,-0.06317758,-0.065965466,0.07009048,0.10502033,-0.046737555,-0.02175313,0.007187758,0.004847352,0.10151593,-0.060084276,0.047079604,0.05105508,-0.060257684,0.06270446,-0.0020454992,-0.035309218,-0.05336803,0.1718832,-0.048181415,0.064929344,-0.017746216,-0.03938447,-0.06390266,-0.02397886,-0.11171093,-0.042532846,0.044649117,0.099139474,-0.056379154,0.025561783,-0.008023451,0.032442726,-0.06298186,-0.089080326,0.04084631,-0.0768424,0.048514023,0.03578194,-0.014744133,0.03025999,-0.04236162,0.009450395,-0.00680914,-0.022729995,-0.033417884,-0.03556779,0.04120417,-0.082662724,-0.0516291,0.013324328,-0.092980914,0.010794742,0.049986977,0.040217124,0.0004014557,-0.0024811286,0.011936148,-0.004163577,0.041770656,-0.010876095,0.03737837,-0.025268806,-0.0071367463,-0.010369466,0.036592312,-0.014337441,-0.009200533,0.040580682,-0.0054446156,0.009318042,-0.008997285,-6.5238743e-34,0.042595867,-0.07815533,0.06504342,0.07943834,-0.04357728,0.04142961,-0.0086064255,-0.06430179,0.023472965,-0.010174901,-0.06909365,-0.064490035,-0.015800387,-0.007733158,-0.079856075,0.018432623,-0.058423825,-0.048188,-0.0053516123,-0.0036598116,-0.10139998,0.13146086,0.012810833,-0.09713201,0.015462688,0.07769565,-0.036249153,-0.08487674,0.059009,-0.03072723,0.012336835,0.013362177,-0.10107321,0.036934897,-0.0074814027,0.021502838,0.067534,-0.04752682,-0.052047707,-0.03873894,-0.0021172178,0.0027686283,-0.019139592,-0.026902942,0.021334216,-0.051165257,-0.016429704,-0.042404335,0.04163173,0.0101648765,0.10671574,-0.06573913,0.04833126,-0.0390991,-0.08546204,-0.011027348,-0.010466805,0.0053322283,0.035041917,0.07021042,0.09295773,-0.057912588,0.0028342206,0.0851984,0.045358438,0.043754574,-0.062414102,-0.06395777,-0.012913857,0.060694616,-0.0062273685,-0.006672606,0.11255099,0.008997511,0.011329993,-0.015483675,0.014036648,0.1086267,-0.06106099,0.079455666,0.027802879,-0.068147294,-0.030958017,0.043717094,-0.062916584,-0.033995647,0.02507877,0.012403262,-0.014100505,-0.033457357,-0.0090391375,0.03510384,-0.039024323,0.045916453,-0.064953886,-1.7006779e-33,0.032568023,-0.05179748,0.07649192,-0.051696174,-0.041155044,0.06066903,0.054366853,0.045151357,0.0061159534,-0.0142393205,0.0596406,-0.09191431,0.014390806,-0.044390757,-0.06415136,0.038401537,-0.017172905,0.08795701,-0.08343256,-0.048478026,-0.10182396,0.04129082,0.038265307,0.07616349,0.072318904,0.004159267,-0.06203462,0.02418509,-0.047726486,-0.046913095,0.010894939,0.016761072,-0.09984547,-0.03464554,0.011509601,-0.011353389,-0.006215006,0.012667037,0.017222317,-0.12511814,-0.014998884,0.065184094,0.09802215,0.08795841,0.020888394,0.07078637,-0.04035616,-0.0040567843,-0.026939368,0.0046137045,-0.05378481,-0.041172463,0.033393655,-0.01578357,0.08584981,-0.029216595,0.05400866,-0.02071992,-0.011885266,0.0038512396,-0.011921175,-0.052927263,-0.049684364,0.049160123,0.053226646,0.045199655,-0.101724654,-0.0713348,0.041150063,0.08825073,0.043813728,-0.075215146,0.039886672,-0.022343764,-0.06375714,0.07452942,-0.02825801,-0.055959847,-0.024359193,-0.023438,-0.022587452,-0.024371145,-0.056774773,0.04468569,0.020755565,-0.09200334,0.06447756,0.06542319,0.08420891,0.017224537,-0.03759688,-0.019741127,0.022330659,0.03538338,0.003470946,-2.1521405e-08,0.11916136,-0.05430493,0.052307196,-0.0813678,-0.06619526,0.034895565,-0.044468805,0.033038616,0.029566932,0.008663378,-0.043683447,0.009897146,-0.016294202,0.007970704,0.010861086,0.009178155,0.028245315,0.05401718,0.023978155,-0.0048121,-0.03331912,-0.049555104,-0.0006707873,0.040090647,-0.057203643,0.0007727214,-0.017618177,0.10067164,0.026824145,-0.04769394,0.04923649,-0.009911594,-0.051431093,-0.01747195,-0.024677195,0.07692957,-0.0035275219,-0.0363532,-0.0008859208,-0.0041547576,0.013154183,-0.043230284,0.010592718,-0.043816138,-0.04648439,-0.042420905,-0.006351823,0.01973439,0.041363865,-0.037674844,0.007173581,-0.006824534,-0.0650667,-0.04574679,-0.058366574,-0.019138068,0.017501183,-0.037221733,0.056262907,-0.01929884,0.028642539,0.038486455,0.08989075,0.094603546 +3.4.21.41,"Activated from proenzyme C_overbar_1r_ in plasma during activation of the complement system by the ""classical"" route. In peptidase family S1 (trypsin family)",384,1.0,-0.050707787,-0.017792344,-0.027294632,-0.02817157,-0.012627616,0.057990473,0.03369761,0.14551443,0.030568536,0.036391273,0.018882832,-0.05827655,-0.018580556,0.04453837,-0.025847431,0.008296896,-0.004926328,-0.038507413,0.022852875,-0.08196033,-0.027483717,0.019084362,-0.037962995,0.01991087,-0.026705569,-0.05870479,-0.042463064,-0.0003748726,0.04963808,-0.017447047,-0.070886694,-0.028625142,-0.020443093,-0.018729176,-0.031215185,0.027025385,-0.016345099,-0.026597755,-0.015149654,0.02166987,0.027223354,-0.021526966,-0.09991447,-0.04084935,-0.037391465,0.05207864,0.033265553,0.13801752,0.061998513,0.023936756,-0.010061169,-0.014003131,0.076042645,0.020646024,0.049342163,0.064651005,-0.08142007,-0.05089663,0.023892274,-0.01958172,-0.118002094,-0.031523604,0.009555892,-0.026224392,0.07311581,-0.07920873,0.023013545,0.012089807,-0.011871818,0.024751497,-0.00048477232,-0.07379744,-0.04917675,0.06800972,0.010485401,0.008001897,-0.048018366,-0.061243348,-0.043388758,-0.04106495,-0.004448329,-0.040795524,0.018098405,0.077953786,0.006189708,-0.0052809417,-0.038380202,0.009680699,-0.025227224,-0.008393424,0.0098944595,-0.108566,0.025703203,0.009489309,0.013351631,0.0188225,0.0033582738,-0.040936306,0.037291855,-0.0036987616,0.010300358,-0.020866022,0.024805091,-0.004284601,-0.034108177,0.053173732,-0.0300721,0.06628058,0.059029806,-0.0647555,0.009346382,-0.095000654,0.06685221,-0.05837333,-0.051291645,0.080964096,0.013299792,-0.0067473096,0.005393829,0.0068434314,0.005726162,0.017769186,-0.043419845,0.053495184,-0.075522736,0.0833189,0.017591776,5.5824187e-35,0.018593928,-0.007238676,-0.028982267,0.038322173,-0.03756934,0.026770232,-0.051833175,0.02863527,-0.024795802,-0.017440228,-0.09941186,-0.12466432,0.01851968,0.02722449,-0.051797654,-0.0030355733,-0.06412577,-0.0785062,0.055495337,0.033112627,-0.033559483,0.09133571,-0.0020412058,-0.057587482,0.04848127,0.06261478,-0.028167864,0.008310369,-0.022337886,-0.014756584,-0.03061576,0.029517531,-0.05453403,0.01316138,-0.0410674,0.015165453,0.13111725,-0.045415387,-0.03191372,0.014761805,0.02494692,-0.012605343,-0.10897558,-0.0531914,0.094124556,-0.061508577,-0.10565589,0.015368443,-0.003080795,0.075609684,0.113280885,-0.019782519,0.037686046,0.015748665,-0.064057045,-0.0064661577,-0.08656312,0.048114717,0.069872364,0.06095892,0.04459071,0.0044528516,0.021700889,0.026131514,0.023824198,0.07396084,-0.062860236,-0.061606426,-0.025846796,0.0086980155,-0.09740918,0.029633744,0.02421006,0.052576054,0.033656087,-0.05508653,-0.004897934,0.10412486,-0.051535916,0.06571286,0.04150168,0.011777896,0.025535148,0.11854442,-0.04422172,-0.081112236,0.03204253,-0.09237467,-0.12272959,-0.03674954,0.07759185,-0.020968132,-0.040404897,0.10606213,-0.024753485,-2.759307e-33,0.03782138,-0.09759598,0.03631815,-0.04045797,-0.05639724,0.03808615,0.03902666,-0.054128796,-0.027490746,-0.011292722,0.10453302,-0.026089745,-0.05443045,-0.05779179,-0.051371243,-0.012062047,-0.012874903,0.12721577,-0.07158834,0.0017764472,-0.06894593,0.008158431,0.043861523,0.019181784,0.05069632,0.011900519,0.005326071,0.06312118,-0.005039458,0.016824156,-0.028763521,0.008157705,-0.047601465,-0.007396975,0.03458787,0.06329311,-0.060345612,0.07774338,0.045030583,-0.04688245,0.030441118,0.09855396,0.05559882,0.05232759,0.049771525,0.07475531,-0.01178561,-0.06895899,-0.061235275,-0.08675401,0.02535791,-0.019283129,0.006105735,0.07188184,0.045688864,0.002950886,0.078836896,0.029383674,0.029767286,0.025533805,-0.019705586,-0.027158776,0.029301513,0.0266076,0.06441842,-0.02024986,-0.057121817,0.0054582506,0.113641374,-0.020548904,0.092144646,-0.03284971,0.06462944,0.03135515,-0.009772134,0.09356838,-0.041704137,-0.043343104,-0.03104102,-0.039869703,-0.13027366,-0.06077528,-0.02641473,-0.019193625,0.088681296,-0.00924036,-0.03571005,0.032881442,0.019317448,-0.014725183,-0.01837601,-0.0060038804,0.009573105,-0.03420597,0.03550935,-3.0908044e-08,0.15421298,-0.07858283,0.017021047,-0.05707672,-0.028375352,0.057283983,-0.030726021,-0.023455767,-0.032454975,-0.048775468,-0.0062851617,0.0206805,0.017279044,-0.03853046,0.06537142,0.054111496,-0.024093565,0.083626464,-0.023450222,-0.049821556,-0.09922738,-0.014969539,-0.0021129453,-0.020804292,-0.020008596,-0.085407026,0.018983737,0.1002586,0.057068296,-0.10183464,-0.0129074715,0.0057558776,-0.03632207,-0.008286756,0.0403527,0.08311132,0.02103267,0.027199984,0.025046783,-0.017616384,-0.018315244,-0.07160571,-0.021863583,-0.05099081,0.035686392,0.028280605,0.030228596,0.06642965,-0.015313632,-0.03501669,0.038671307,0.0052047465,0.011802749,-0.010783077,-0.08458627,-0.0062991763,-0.057290334,-0.0370908,-0.008343457,-0.09536505,0.009395132,0.10060953,0.012414933,0.0046209386 +3.4.21.42,Activated from proenzyme C1s in plasma by complement subcomponent C_overbar_1r_. In peptidase family S1 (trypsin family),384,1.0,-0.03676699,-0.005522439,-0.055613436,-0.037932023,0.04072354,0.06984746,0.05258494,0.1496572,0.012830936,0.020184733,0.017153714,-0.096277,-0.018131658,0.05197242,-0.044785943,-0.010954511,0.023973813,-0.039584186,0.012327898,-0.08345505,-0.07078058,0.017645933,-0.029494686,0.048910357,-0.010042849,-0.054852992,-0.046661507,-0.006638092,0.049482197,0.015061134,-0.063175805,-0.025445454,-0.011410684,-0.0030327667,0.0041976366,0.022681123,-0.03254804,-0.021745613,-0.013434468,0.034121674,0.030161485,-0.0106250355,-0.10053056,-0.049598306,-0.042050473,0.03259786,0.021801664,0.15884687,0.078886494,0.04986524,-4.8341673e-05,-0.020011352,0.053422987,0.016838716,0.039124314,0.03690906,-0.0821816,-0.053328868,0.05311216,-0.023503246,-0.1118982,-0.040047422,0.039930213,-0.017803222,0.047415525,-0.078656234,0.015350426,0.025427517,-0.03931916,0.01662404,-0.002831254,-0.06341725,-0.009198095,0.07213807,-0.0030261811,0.026916323,-0.05517854,-0.06933268,-0.03073954,-0.05586521,0.008446925,-0.028143508,0.014969473,0.106179625,0.034056466,-0.040825613,-0.024355773,0.03724148,-0.029114548,-0.028791295,0.02851767,-0.07827932,0.073678635,0.03360053,-0.025327593,-0.0005245827,0.0096035795,-0.023434296,0.04718818,-0.027848523,0.0028771798,-0.024184337,0.055424996,-0.047291934,-0.066647805,0.06979405,-0.050682392,0.08250153,0.07825008,-0.032568607,0.013249476,-0.06754523,0.03254765,-0.1008126,-0.021169236,0.06942097,0.03785273,-0.02336765,-0.032842413,0.008114039,0.028211318,0.02840567,0.01023934,0.03774751,-0.041728564,0.07519061,0.053742476,1.8533037e-33,0.008118841,-0.021119177,-0.058186784,0.05395809,-0.01695114,0.04091358,-0.025737466,0.03937068,-0.027662434,0.0025523033,-0.09629086,-0.106213145,0.0011825957,-0.0019739752,-0.05343373,-0.006256678,-0.0139941,-0.09204202,0.027530907,0.049930267,-0.02790796,0.08109289,0.0089988755,-0.06531346,0.0576418,0.027182568,-0.0407611,0.029326523,0.01536161,-0.034970306,-0.030861601,0.043099843,-0.047246933,0.011267712,-0.035665534,-0.026880711,0.08742564,-0.037054207,-0.02582887,0.015951969,0.011360234,-0.01751041,-0.0870099,-0.07580605,0.10699658,-0.08926561,-0.093347244,0.020522287,0.008745745,0.099814735,0.11076008,-0.037721675,0.04447005,0.025486423,-0.05381684,-0.002594812,-0.08435542,0.054103483,0.0946942,0.032596283,0.008504326,0.018936997,0.007991066,-0.0035514892,0.0035373894,0.04296436,-0.04655481,-0.035699714,-0.051517203,-0.026905764,-0.07755348,0.017569402,0.04770051,0.04955673,0.024920505,-0.05935038,-0.018732162,0.09868048,-0.042997506,0.05320279,0.043924727,0.01530919,0.012763634,0.10470145,-0.055312466,-0.06000155,0.002419309,-0.059863206,-0.118240766,-0.029344492,0.06818782,-0.048224762,-0.04657667,0.086875334,-0.032375365,-4.1771188e-33,0.06722509,-0.09805834,0.028196665,-0.05019195,-0.04758731,0.042181253,0.044537075,-0.07787874,-0.014409123,-0.001089843,0.10007799,-0.042126257,-0.059398156,-0.06753017,-0.08252746,0.030600028,-0.01613664,0.13883598,-0.068173505,-0.02069873,-0.06371801,-0.01634647,0.059002686,0.02462119,0.054397188,0.029900074,0.0075461734,0.032864172,0.04027302,0.034884334,-0.018400038,4.0686333e-05,-0.05234529,-0.023033954,0.055597883,-0.0008685112,-0.05685657,0.04755394,0.048308995,-0.054565776,0.026956167,0.09718256,0.053949244,0.04426817,0.04096776,0.07852535,-0.015972508,-0.06833949,-0.04426818,-0.097202696,0.003327152,-0.036202896,-0.0055185477,0.088204935,0.031609412,0.0104825925,0.06251155,0.052495882,0.035807025,0.016966471,-0.0059793564,-0.019321818,0.02463533,0.033996414,0.07891014,-0.015142877,-0.09570221,0.004598275,0.12210699,-0.028878145,0.072694555,-0.04447321,0.07012008,0.0037935032,-0.0046085306,0.07511707,-0.026741458,-0.051260788,0.008845567,-0.05556687,-0.079856806,-0.09357005,-0.0149414595,-0.011434619,0.044371266,-0.044299785,-0.016527371,0.0112049775,0.02192524,-0.02094883,-0.020250738,-0.000973616,0.03537539,-0.0047993525,0.061155368,-3.091328e-08,0.15518443,-0.074395485,0.011137064,-0.083045796,-0.009498006,0.021693785,-0.06320092,-0.025182964,-0.009688053,-0.024052644,0.0057416675,0.0090003675,-0.016150745,-0.03509773,0.03315863,0.035459027,-0.056761444,0.0647587,-0.006671009,-0.023627121,-0.08188849,-0.010245601,-0.015808996,-0.026151694,-0.007219907,-0.0833381,0.035159264,0.080947235,0.049788702,-0.0818517,-0.052541506,-0.011464383,-0.019434353,-0.020278195,0.085809976,0.075474024,0.00717057,0.04404731,0.02802675,-0.022531386,-0.013807243,-0.08095472,-0.012242916,-0.06524087,0.027744837,0.005448386,0.018362433,0.08330947,-0.017229937,-0.022032544,0.036278546,-0.013526358,-0.014992142,-0.02386504,-0.060438722,-0.021328237,-0.046122305,-0.026928294,0.010921396,-0.11550546,-0.0064009093,0.092799105,0.029926972,0.025021082 +3.4.21.43,"A complex of complement fragments C4b, C2a and C2b. C2a contains the active site, C2b the site for C4b binding. C2a and C2b are formed by cleavage of proenzyme C2 by complement subcomponent C_overbar_1s_. Cleavage of C5 requires complement fragment C3b which binds C5 and renders it susceptible to cleavage by the C4b,2a complex. Includes former EC 3.4.21.44. Complement component C2a is in peptidase family S1 (trypsin family)",384,1.0,-0.05145403,-0.0041155345,-0.017392023,-0.054453045,0.055403434,0.04956516,-0.012621339,0.09317028,0.021921918,0.004826892,0.02988904,-0.12393532,-0.034892827,0.033664178,-0.021255968,0.02062323,-0.057086207,-0.010265069,-0.0056127696,-0.028979914,-0.027360281,0.029877555,-0.04270488,0.012406766,-0.024421599,-0.024388513,-0.02947681,0.018116223,0.09708057,-0.054571617,-0.07470667,0.002088922,-0.011345971,-0.024639798,0.029421581,0.018748058,-0.0038788463,-0.022318842,0.031858932,0.017984947,0.0355071,0.032804117,-0.040525597,0.011737302,0.003160827,0.0711937,0.0066202767,0.122321665,0.014063591,-0.049979333,-0.021985058,-0.06900759,-0.019011049,0.0645812,0.0028090456,0.070788294,-0.07919888,-0.03145114,0.045820095,0.035352018,0.017877437,-0.017708967,0.01959916,-0.027598767,0.08419745,-0.030656038,0.037132602,-0.016834926,-0.0022643215,0.055767085,-0.06457767,-0.079813294,-0.08915308,0.107043,0.042239152,0.05106598,-0.030153492,-0.06567406,-0.003025497,-0.072286986,-0.059935957,0.018834231,0.043143496,0.09806679,-0.00060002436,-0.037967127,-0.008766029,-0.014305696,-0.0048778052,-0.021641916,0.034545112,-0.036787957,0.040982533,0.0010054857,-0.036151912,0.05835968,-0.0069634425,0.013420071,0.065850824,0.019179087,0.009567419,0.0042528617,-0.0008694799,-0.06656504,-0.0388272,0.03030311,-0.049417805,0.08628687,0.06548316,-0.06296026,-0.015255395,-0.07583826,0.033121996,-0.11840837,-0.006094903,0.028400317,0.07103908,-0.02238581,0.038654257,-0.0044227066,0.039659593,0.015389173,0.0066315206,0.055746373,-0.056983925,0.01626926,-0.09769297,6.4866166e-33,0.05219539,-0.013068617,-0.009648843,0.08797428,-0.057351932,0.003416455,-0.034671184,-0.024065362,-0.083418936,0.051126126,-0.13057283,-0.09492771,0.016904665,0.0027876508,-0.03136625,-0.0088527305,-0.031025773,-0.025242364,-0.007944779,0.02940314,-0.0509104,0.09639449,-0.016226642,-0.059393667,0.119379826,0.05770936,0.009177391,-0.022186631,0.02071557,-0.033844598,-0.036259208,0.028897304,-0.0807197,0.032268304,-0.02268893,-0.045176264,0.100698456,-0.060461696,-0.05520106,-0.0012445688,0.033860706,0.027386647,-0.05167769,-0.050848853,0.116040304,-0.096153036,-0.0420314,0.059095595,0.036731385,0.03300458,0.098282896,-0.016707633,0.058408726,0.04426641,-0.09795615,0.018234262,-0.08375037,0.056499433,0.087966345,0.07246771,0.038108952,0.020689726,-0.040312544,0.03441228,0.0128435595,0.11367726,-0.08917374,-0.055905476,-0.008461836,-0.028996207,-0.083894,0.0009314654,0.109051846,0.051757853,0.035565037,-0.051298168,-0.060046166,0.060364425,-0.03090394,0.09213057,-0.03937995,0.018134734,0.05154409,0.047014926,-0.08071111,-0.1119955,0.05384391,-0.12157528,-0.047739517,0.0060991403,0.02454395,-0.04199606,-0.020728316,0.078695655,0.007642101,-6.7771665e-33,0.056748144,-0.08363666,-0.002716239,-0.06867988,-0.08022218,-0.0005081399,-0.0018709188,-0.09503843,-0.021371696,0.015148239,0.15646546,-0.025011983,-0.017366093,-0.07554685,-0.034646127,0.022019498,0.014699877,0.09063414,-0.023287179,-0.00979476,-0.03874041,-0.007105959,0.025917089,-0.0032154045,0.053447824,0.051803324,0.0069981753,0.029913314,0.01639891,0.0136841955,-0.06387938,-0.012093997,-0.05076558,0.013958528,-0.009789234,-0.029287977,-0.07812036,0.029725624,0.043200914,-0.083098784,0.048223414,0.06364604,0.022360573,0.09466666,0.025607932,0.057188544,0.007902906,0.028970521,-0.028009733,-0.0588702,0.015754227,-0.064416006,0.0006025403,0.009256022,0.041926626,0.041708853,0.08808203,0.011461421,0.02167679,0.04861739,-0.017529283,-0.016513802,0.0001961822,0.059585065,0.12245188,-0.0028658505,-0.095840864,0.018645192,0.06574065,-0.023872422,0.06769654,-0.027099906,0.041138053,0.006785593,0.011488295,0.050643437,0.012251299,-0.010351465,0.0049691284,-0.031251542,-0.09341591,-0.05568089,-0.0024939748,0.0023585605,0.05715452,-0.0041644424,-0.056866113,0.06071434,0.01786638,0.0017077596,-0.052487746,0.011939267,0.03228896,0.023408394,0.063649096,-4.431316e-08,0.1581964,-0.02749406,-0.02068039,-0.110722125,-0.00077218516,0.042652845,-0.056220155,0.0128336735,0.010141531,0.009336197,0.03400794,0.0030775722,-0.025417708,-0.07286144,0.013683099,0.024653925,-0.0598085,0.045735415,-0.052681047,-0.046765342,-0.101443924,-0.030425495,0.0039383997,-0.013925884,-0.0023503639,-0.105801895,0.012292271,0.095624365,-0.0030267257,-0.05242185,0.0076052584,0.005465471,-0.032302134,-0.013675432,0.072001405,0.09125647,-0.031132389,0.010960673,-0.01582813,0.050305247,0.01346325,-0.10823832,-0.037359975,-0.036250096,0.06834619,-0.016270991,0.0010336356,0.020294053,-0.0077678454,-0.02361779,0.008124245,-0.007521939,-0.019830372,-0.028374631,-0.077538684,0.0012364739,0.0015487409,-0.006543034,0.023958184,-0.07167416,0.006147793,0.053772423,0.045645013,0.018687833 +3.4.21.45,Cleavage of complement subcomponent C3b requires its binding to cofactor factor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. In peptidase family S1 (trypsin family),384,1.0,-0.006014849,-0.02769557,-0.052877024,-0.04181867,0.03422732,0.07713669,0.004872545,0.059141863,0.02920159,-0.013711684,-0.010272361,-0.12990865,-0.023252636,0.053301316,0.01761701,0.019471858,-0.0045703775,-0.029077388,0.028781181,-0.07029375,-0.07423413,0.012427279,-0.029922416,-0.00039318486,-0.0612059,-0.028667249,-0.045141626,-0.055782046,0.05691858,0.023025492,-0.11181596,-0.037900828,-0.01624345,-0.014117926,0.016928788,-0.0075864093,-0.0072272345,-0.018049166,-0.01118814,0.005773984,0.03141987,0.06847205,-0.024176087,0.0030809373,0.023499345,0.062489133,0.030974366,0.12643498,0.038231846,-0.03321783,-0.017157217,-0.027642364,0.011792191,0.06798489,0.014954497,0.07808842,-0.071082644,-0.02298318,0.070288904,-0.010894297,-0.085131474,-0.047406238,0.05618473,-0.024355914,0.11129944,-0.046979252,-0.039114747,-0.027280033,-0.026328348,0.07709851,-0.0751627,-0.038103517,-0.09242922,0.081580885,0.05164213,0.068309985,-0.012325752,-0.042306945,0.024456523,-0.052296974,-0.032526426,0.035800982,0.05378891,0.10719683,-0.014690278,-0.008833296,-0.020787608,-0.060260214,-0.067334004,-0.012562044,0.046112113,-0.044222493,0.027224101,-0.013304181,-0.054079924,0.009861916,0.011464454,0.021010984,0.05399067,0.0043208078,-9.478293e-05,0.02457844,-0.014334923,0.0055674007,-0.06761799,0.030267138,-0.06963241,0.087464936,0.063146524,-0.0478161,-0.012608417,-0.05739077,0.039549712,-0.10628973,-0.0019663752,0.015890377,0.07652657,-0.056312963,0.049548816,0.009305607,0.027437769,-0.006828273,-0.026814304,-0.02041426,-0.042984247,0.026359366,-0.05740618,7.454254e-33,0.0327911,0.02108415,0.011151396,0.07991423,-0.09468522,-0.012562984,-0.023731956,-0.0037961167,-0.054265972,0.009996276,-0.09971359,-0.11974536,0.022273816,-0.0064945742,-0.07931,0.020350741,-0.044010717,-0.06903941,-0.024747625,0.04827087,-0.0386853,0.07928798,-0.0037657628,-0.05471096,0.07758696,-0.009540427,0.02363094,0.031945143,-0.010720494,-0.03979756,-0.04638438,0.06517282,-0.062825255,0.011004079,-0.037920088,-0.061892852,0.12991104,-0.071437165,-0.049996633,0.002983867,0.041818008,0.014644401,-0.05796805,-0.07817401,0.10291788,-0.09703786,-0.02226824,0.03296489,-0.024531078,0.059764985,0.09848237,0.01753342,0.05689681,0.046495054,-0.051175393,-0.012752761,-0.07416876,0.00015864274,0.11490035,0.024529055,-0.00944874,-0.028335461,-0.0049580806,0.07487595,0.0035107662,0.0956586,-0.043930154,-0.03952007,-0.02660066,-0.012988623,-0.056380533,-0.004308686,0.03609625,0.023450274,0.027731149,-0.08106865,-0.028642492,0.062534325,0.018731762,0.08697894,0.0005857211,0.060851965,0.09376206,0.08311,-0.07057657,-0.14532213,0.035071764,-0.12428257,-0.049027402,-0.01799043,0.04351072,-0.024677867,0.028029224,0.12021696,0.002226794,-6.791711e-33,0.080578014,-0.09252626,0.003262796,-0.08116899,-0.06732955,-0.0046028844,0.0014775768,-0.09266808,0.0749911,0.027037436,0.115953386,-0.010494562,0.0025642475,-0.06968027,-0.007742259,0.019168364,0.017743621,0.05395773,-0.05069639,-0.016634662,-0.014242601,-0.01068845,0.035342786,-0.043541085,0.011251891,0.028283352,0.009247558,0.0544891,0.0014045833,-0.011847939,-0.08557363,-0.00579976,-0.03460578,0.03227347,-0.025054127,-0.04763918,-0.022861639,0.06277789,0.045161508,-0.070826665,0.050389003,0.079635955,0.03987203,0.086537704,0.029823605,0.05242636,0.0097727245,0.018596454,0.005464811,0.008706416,-0.0067262733,-0.09038239,0.019387392,0.012916292,0.042307485,0.047896724,0.07862839,-0.015596978,0.06108683,0.08127986,-0.04573923,0.00495625,0.042983394,0.081570856,0.088358015,0.012760875,-0.09701956,0.027076963,0.12369977,-0.03107891,0.0444014,0.041040935,0.07804443,0.029693965,-0.0034901835,0.0524676,-0.048802305,0.007403256,-0.018576942,0.023951164,-0.105360486,-0.049705233,0.00040009298,0.022927668,0.068662964,-0.0130758,-0.0518222,0.010756966,-0.019518282,-0.01647667,-0.058878712,-0.043075576,0.0821854,0.035126824,0.012438537,-3.4082102e-08,0.08557679,-0.01826518,0.011104809,-0.08178653,-0.074320436,0.09057101,-0.03770254,-0.033408266,0.01750303,0.00012816742,0.034025695,-0.03802138,-0.009211949,-0.056019343,0.0023535194,0.00955098,-0.025655642,-0.012269182,-0.04258547,-0.040010065,-0.092232645,-0.03956551,0.043402527,0.014615588,0.061467823,-0.09465787,-0.03098571,0.11444201,-0.012614011,-0.0434247,-0.047935266,0.0025201142,0.0015963567,-0.0009322969,0.06813767,0.048758924,0.0088339755,-0.0074565806,0.019054161,0.004284378,0.039299022,0.017053725,-0.04366259,-0.063537054,0.037785124,-0.018839898,-0.019235646,-0.0057949764,-0.0135689555,-0.046723034,0.0409139,-0.033539824,-0.047785632,-0.01436551,-0.010550742,-0.024426382,0.0034097834,-0.008861954,0.07255064,-0.046052054,-0.021747446,0.07468325,0.02653138,0.022516469 +3.4.21.46,A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C_overbar_1s_. In peptidase family S1 (trypsin family),384,1.0,-0.037744384,-0.0012241293,-0.014170052,0.0045216153,0.030640168,0.1001713,0.033598527,0.12113633,0.06335042,0.016449608,0.0058685835,-0.10630121,-0.010687968,-0.0009213691,-0.02031337,0.023695571,0.0009347493,-0.019222362,0.0014663177,-0.069458805,-0.044827685,0.03032885,-0.0054734135,0.010426972,-0.055438768,0.00035411224,-0.05666005,0.011857849,0.078386635,0.0046315957,-0.105759636,-0.012586964,-0.02418477,-0.012479684,-0.059550304,0.03767786,0.0029114282,0.011612219,0.0054537565,0.004432758,0.0048232274,0.0062362747,-0.05833736,-0.01829167,-0.01685051,0.079387166,0.016924756,0.109606326,0.027757995,-0.032175537,0.017534243,-0.031538237,0.029626144,0.020925933,0.062358066,0.07601664,-0.07768381,-0.066442356,0.03281283,-0.026620062,-0.04726211,-0.047264982,0.027157338,-0.023519969,0.08386937,-0.09013492,-0.021423597,0.006991431,-0.012896819,0.040262852,-0.047614433,-0.07865243,-0.06406949,0.068493746,0.03140438,0.025673058,0.015113927,-0.035357427,0.0006684113,-0.039718445,-0.0013473867,0.019152105,0.0099957315,0.08461089,-0.005870909,-0.05100844,-0.0184256,-0.015522908,-0.0045595053,-0.016970143,-0.00355165,-0.086788744,0.04720391,-0.024992386,-0.0035510827,0.01653926,-0.0122612575,0.004973722,0.03235412,-0.0032572306,0.014060611,0.0025185498,-0.00017852384,-0.04624193,-0.04786137,0.027502507,-0.042427655,0.04809559,0.116465166,-0.09843888,-0.052161347,-0.11673133,0.04403508,-0.10678457,-0.041128423,0.037780244,0.049763966,-0.038212243,0.0325845,0.01951279,0.03556073,0.022183882,-0.056874987,0.03820367,-0.06443137,0.0144037865,-0.04279873,1.0830079e-33,0.050841425,0.01456521,-0.01857017,0.026182568,-0.02134383,-0.015198315,-0.037565336,-0.025497748,-0.046794165,0.00045128856,-0.1262898,-0.11548924,-0.0070566013,0.03573552,-0.069039695,0.013440659,-0.06295295,-0.04234791,0.06572496,-0.015894435,-0.0771135,0.107603915,-0.0019698106,-0.042526275,0.089523755,0.0027511367,-0.0038470258,-0.025484227,-0.035243712,-0.036319107,-0.0412169,0.089935444,-0.05699096,0.023945143,-0.032573186,-0.028859215,0.10168246,-0.06610582,-0.028894676,-0.0021561997,0.005744291,0.0065026307,-0.09477867,-0.047775466,0.09364119,-0.07768286,-0.085821345,0.033532143,0.020749353,0.07369567,0.11099989,-0.01097062,0.059259027,0.022208385,-0.068443395,-0.00070046994,-0.08675456,0.05452067,0.072469585,0.04099917,0.0010044139,-0.0018765237,-0.028296703,0.03221498,-0.0037282465,0.08349622,-0.054976422,-0.06381979,-0.0041201855,-0.007585565,-0.11997919,0.02109667,0.028772675,0.03948224,0.012853656,-0.073532335,-0.049408495,0.085626714,-0.03851845,0.09625606,-0.010997979,0.027356004,0.0039551836,0.068909675,-0.024383869,-0.07930805,0.035330478,-0.114804134,-0.0673058,-0.033308584,0.017084645,-0.0422904,-0.049016196,0.11445748,0.023584355,-3.201417e-33,0.014002139,-0.12235998,-0.000930702,-0.032741968,-0.0559146,-0.02085704,0.027523244,-0.107578896,-0.00026314615,0.031253986,0.105237424,-0.032509953,-0.0039327964,-0.050395425,-0.057306707,0.00040415747,0.00881271,0.13894598,-0.0528242,-0.044819128,-0.014335083,-0.0039350875,0.041055847,0.017569896,0.039637793,0.0177013,0.0062952116,0.044687558,-0.012782532,-0.010190221,-0.03047448,-0.035012886,-0.038969345,0.018074213,0.04276476,0.01410711,-0.026090717,0.06382043,-0.008131659,-0.05414126,0.06157446,0.07060331,0.1102081,0.09458032,0.045578167,0.05556437,-0.016477674,-0.052691534,-0.07617148,-0.075107045,0.020704286,-0.024918934,-0.008298282,0.07903456,0.08432725,0.016035248,0.06572657,0.010303458,0.059905145,0.03918892,-0.015407099,-0.00784287,0.005169577,0.042911883,0.114636086,0.028880052,-0.092856176,-0.006822761,0.094606586,-0.006417304,0.10701357,-0.037521392,0.054906115,0.008999156,-0.0060184184,0.04714197,-0.01976573,-0.024840467,-0.037977543,0.00868815,-0.12129633,-0.08423598,0.0244974,0.027755903,0.06877573,-0.0031376684,-0.0508127,0.06638479,0.00036950328,-0.018419567,-0.039240807,-0.012414384,0.022716282,-0.013766687,0.016125,-3.194567e-08,0.112088285,-0.057199523,-0.012439578,-0.09344497,-0.018233374,0.06392234,-0.04538586,0.007193765,-0.0252746,0.013044405,0.030077033,0.026379982,0.010591389,-0.07132381,0.06583205,0.05387165,0.0037178316,0.05438995,-0.012582457,-0.05670621,-0.10039893,-0.008293921,0.009662325,-0.0020982304,0.0057448866,-0.11714093,0.023729717,0.11896495,0.040635098,-0.08219827,0.011705519,0.012108195,-0.031714074,-0.021089518,0.058384433,0.09498217,0.002089811,0.0064197727,0.027067652,-0.026348904,0.01626173,-0.035177357,-0.024961727,-0.03209988,0.053807467,0.023749245,0.008878331,0.023256794,-0.034020778,-0.025139809,0.041150574,-0.0046364767,-0.0019157819,0.01723007,-0.071558826,-0.002150414,-0.0021300395,-0.0070877485,0.025889851,-0.05857953,0.018736081,0.09881199,0.047121756,0.03134118 +3.4.21.47,"A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. Bb is formed by cleavage of proenzyme factor B by factor D. Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. C3b,Bb is stabilized in plasma by factor P. Complement factor B is in peptidase family S1 (trypsin family)",384,1.0,-0.053542137,-0.014822691,-0.0482071,0.017255975,0.02514641,0.066547446,0.036605816,0.043734524,-0.023894496,-0.021832727,-0.008986246,-0.1008801,-0.008425202,0.08901469,-0.006215634,0.03490097,0.013472177,0.037390027,0.013131755,-0.009997717,-0.056161433,0.022412816,0.0010964265,0.020990789,-0.030417927,-0.0066953995,-0.017592635,-0.02014277,0.05322044,-0.06736365,-0.082318895,0.03371986,-0.01515723,-0.06857328,0.034688935,-0.015261067,-0.07927069,0.04185564,0.0018340986,0.019662805,0.018835992,0.038732357,-0.011486802,-0.0014411685,0.021264995,0.04839933,-0.019152354,0.12341128,0.0147470115,-0.0477539,-0.066962644,-0.03569237,-0.06707749,0.04522781,0.057538606,0.010643526,-0.055739462,-0.045246404,-0.008680404,-0.03049629,0.010482697,-0.01573422,-0.008689988,0.007880484,0.10976195,-0.044594027,0.022264117,0.0020367461,-0.009152951,0.0399293,-0.058333963,-0.08542335,-0.08108444,0.06586128,0.02898308,0.03440211,0.026596216,-0.012471404,0.029180745,-0.014049583,-0.06894317,-0.011614612,0.023709776,0.13298444,-0.00726835,0.0070874533,-0.021814948,-0.0091997245,-0.0711183,0.01674386,0.036087267,0.007035327,0.042128872,-0.021711087,-0.030693606,0.018758314,-0.012098753,0.0197656,0.0787091,0.02989411,-0.0036195065,-0.017029842,-0.028164076,0.007912143,-0.0114151295,-0.026953062,-0.037716407,0.11383559,0.0846945,-0.042036504,-0.01642264,-0.055767152,0.06351226,-0.11154161,0.018786626,0.0403562,0.05773523,-0.021450585,0.072364785,-0.007937554,0.08607127,0.02269446,-0.0047614733,-0.0038538205,-0.06080347,0.031916898,-0.06622869,6.0226284e-33,0.101665445,-0.02964624,0.0018021748,0.101596124,-0.11198468,0.012803406,-0.08750665,-0.059220556,-0.09211718,0.07365029,-0.078492574,-0.06008476,0.030990733,0.05421051,-0.0503893,-0.03692744,-0.085509755,-0.02566852,0.031185774,-0.011075614,-0.0011020562,0.08934359,-0.07199511,-0.046166725,0.07727148,0.041156773,0.011849252,0.010232574,-0.053434305,-0.0059322054,-0.012172179,-0.018734524,-0.067864366,0.01035448,-0.037836116,-0.08507129,0.06041505,-0.09032415,-0.06342727,-0.028978866,0.031622764,0.017751958,-0.1215668,-0.044483196,0.106789395,-0.109869845,-0.0509898,0.041518215,-0.011211222,0.059254315,0.11954697,-0.020535368,0.1203001,-0.0074531576,-0.0645417,0.03908335,-0.0138622355,0.034529988,0.034392398,0.067376845,0.013395119,0.020213697,-0.055459633,0.024797454,0.017802423,0.08141865,-0.038877364,-0.08598199,0.030858496,-0.06636725,-0.08171532,0.032070182,0.07457019,0.033492077,-0.03142797,-0.044309918,-0.065076,0.04387622,-0.060422402,0.079024084,-0.059520137,0.013180381,0.06973446,0.010576631,-0.0447025,-0.077845305,0.058526095,-0.18205242,-0.053574033,-0.041053332,-0.0152009325,-0.009422278,0.022479355,0.08222441,0.045917008,-6.149635e-33,0.03871095,-0.13457574,0.0147054875,-0.04790472,-0.05642611,-0.024019971,0.017911348,-0.059142005,0.03749958,0.01928217,0.04230385,0.0005070186,-0.0023815131,-0.058993094,0.016295303,-0.012948271,0.036545604,0.06335507,-0.019391282,0.029732125,-0.059080638,-0.0027387394,0.0690039,-0.02678077,0.01648813,0.07883743,-0.014863621,0.0022377216,0.033803858,0.034200303,-0.054431394,-0.009192725,0.0012666038,0.031096786,-0.01694277,0.004505123,-0.024841404,0.022939323,0.014846806,-0.07984567,0.023882015,0.06663902,-0.013766543,0.060239732,0.08212404,0.06234456,0.024034956,0.037325226,-0.021750474,-0.02525627,0.00913151,-0.06506437,0.029931156,0.043437082,0.0144755775,0.0017875991,0.08951103,0.0026735342,0.06791303,0.06373111,0.000111443944,-0.03546257,0.02007863,0.0862383,0.08275746,0.052973274,-0.06802867,-0.0044028447,0.057783894,-0.06509338,0.078886084,0.018340135,0.012540969,0.019158544,0.028078066,0.066034414,0.0066383095,0.035874266,-0.002971435,0.019629365,-0.08096757,-0.0095518865,-0.043484367,0.00685258,0.06532342,-0.025832027,-0.10785203,0.03556858,0.008534541,-0.04720386,-0.08950243,0.0059435563,0.020033939,-0.024541296,0.038131528,-3.8640742e-08,0.14752787,-0.06343278,-0.0199848,-0.07003463,3.7360835e-05,0.0652108,-0.022192959,-0.075529315,0.03914238,0.07404381,0.07086156,0.01762071,-0.014395067,-0.073165186,0.05225467,0.011588832,-0.047692787,-0.015313149,-0.063142024,-0.079303876,-0.048317097,0.007163623,0.032455422,-0.014571211,-0.0035903815,-0.11254812,-0.0043046135,0.01867817,0.026574945,-0.04368204,-0.004049486,0.02258723,-0.0032236413,-0.029919442,0.0053650704,0.07752927,0.02044376,0.005280412,0.061910078,0.050699357,0.0034538363,-0.09285527,-0.03491729,-0.046539202,0.047026206,-0.0044991397,0.007987527,0.0100645395,-0.036173828,-0.060519766,0.012713807,0.0006698012,-0.071141124,-0.045430664,-0.085527666,0.02987508,0.037456978,-0.006694382,0.060062017,-0.06399858,0.04203963,0.03869125,0.066693865,-0.0073725684 +3.4.21.48,"From Saccharomyces cerevisiae (baker's yeast, brewer's yeast). In peptidase family S8 (subtilisin family), but contains a Cys residue near the active site His, and is inhibited by mercurials. Proteinase ycaB is a similar enzyme from the yeast Candida albicans [3]",384,0.99999994,-0.0406727,-0.031393748,-0.10356636,-0.088119,0.09132393,0.040196836,-0.029709104,0.07923448,0.053356748,-0.026417352,0.032632407,-0.0054841046,-0.03460906,0.040391184,-0.048956126,0.00036452292,-0.015221817,-0.034952983,0.037641354,-0.080050856,0.1090412,0.06470112,0.039248466,0.0758623,-0.012362716,-0.050096776,0.008132142,-0.024108838,0.0007102935,-0.055992156,-0.013373412,-0.037892215,0.085456215,-0.03387326,0.07103974,0.008037409,0.094536506,-0.010683079,0.08781607,-0.011173904,0.036646143,-0.012733886,-0.020809725,0.018679941,0.013545739,0.029356042,0.010964198,0.03697968,0.04154886,-0.0050827735,-0.025092503,-0.13635688,-0.023839347,0.05567087,0.01074145,0.021172244,-0.02716652,-0.03887886,0.05291,0.016079195,-0.034429424,0.018606538,0.067905456,0.01776569,0.0087452065,-0.07733096,0.020018816,0.011700068,-0.0087042395,-0.04210422,0.021084474,-0.08022198,-0.08457896,0.09313899,-0.01034005,0.039107572,-0.0033615122,-0.056830008,-0.019051673,-0.035935547,-0.011340967,-0.0072485185,0.083983146,0.12855677,0.007135242,-0.058157858,0.023919232,0.004492323,0.07383182,-0.048609428,0.05704653,-0.031795807,-0.008116661,-0.018944195,-0.05339328,-0.024222312,-0.0067239953,0.028879186,0.052656073,-0.021399183,0.04930664,0.009180756,0.059227206,-0.04829297,0.0027238366,0.12491962,0.01020297,0.062365353,0.05896894,-0.019460332,-0.033859365,0.04262719,0.02201789,-0.03552015,-0.006704284,0.013784343,0.05821809,0.04986269,-0.04036034,-0.08967584,-0.023185385,0.076916136,0.06925305,0.047081437,-0.08528017,0.03420603,-0.1546587,1.6966382e-33,0.021058897,-0.0052722637,-0.039237265,-0.015428305,-0.015378341,-0.033025518,-0.0054187044,0.035917934,-0.031965278,-0.018541,-0.05344306,-0.06933967,0.024130026,0.008570997,-0.068666406,-0.021928128,-0.0057006357,-0.052662708,-0.029606063,0.0055793063,-0.042449784,0.047662783,-0.01492652,-0.017693877,0.06924783,0.025857247,0.009454721,-0.012921332,0.055384852,-0.0298093,-0.030775838,-0.020499542,-0.09609011,0.010004505,0.052980542,-0.009641786,0.05926519,-0.03783862,-0.015067213,0.004271653,0.04021729,0.011364921,-0.0012001694,-0.10404437,0.051117186,-0.036359582,-0.064141065,0.04981459,0.008830162,0.046319965,0.016518604,-0.041677088,0.039206315,-0.019919297,-0.06855116,0.04032458,0.041190766,0.04564299,0.06503838,0.046573885,-0.0013338011,0.0606306,-0.024050377,0.02959177,-0.012742784,0.040149823,-0.05447376,-0.065458596,-0.038987555,0.08292511,-0.09242429,0.029085895,0.037140433,-0.012691193,0.049963366,-0.12872513,-0.09967069,0.02481719,-0.0024883926,0.06835963,-0.018030692,-0.02663867,-0.048152387,-0.009324107,-0.047633052,-0.019815246,0.04185097,0.0048001246,-0.10568503,0.003180168,0.0164998,-0.06517974,0.01573585,0.07636225,-0.031394288,-3.395283e-33,0.075732715,-0.08313253,0.089945786,-0.08825228,-0.058504324,-0.005306426,0.06202404,-0.020038065,-0.0017141089,-0.067908354,0.017579973,-0.03639909,0.05069142,-0.040689208,0.0012143953,0.043530114,-0.03454243,0.05948925,-0.059115097,-0.048714623,-0.011728067,0.08086417,0.05663307,0.033443183,0.05990032,-0.030217486,-0.005945645,0.1579784,0.014793366,-0.036203653,-0.07185748,0.009570892,-0.009355128,-0.084617205,-0.10031765,0.012157518,-0.07714882,-0.007115069,0.01226978,-0.07064079,0.032101057,0.079034105,-0.022387397,0.12188849,-0.020058569,0.11340445,-0.048150238,0.05320962,-0.016197195,-0.00081377645,-0.0022223606,-0.06796551,-0.018206162,0.0076146894,0.032825727,-0.006751569,-0.005312752,0.04501193,-0.048398715,-0.001603705,0.0061434056,0.013105641,-0.008201753,0.044479333,0.074226454,0.09693604,-0.091730855,0.0020781173,0.08730133,-0.014931272,0.13357773,0.054558966,-0.02109988,0.03252283,0.012971987,0.0069927326,-0.098099984,-0.0611499,-0.017130483,-0.08280501,-0.029966932,-0.02702348,0.025475573,-0.014306859,0.029829402,-0.028067332,0.007872107,0.07484245,0.019268671,0.030151898,0.004485565,-0.027669866,0.0046012425,0.08218412,0.043882564,-3.7482103e-08,0.03029317,-0.020759447,0.06862602,-0.063937016,0.012708587,0.016848419,0.013707339,0.007474245,0.043258537,0.006137816,-0.021463538,0.03026041,-0.03990967,0.0031649496,0.0072640716,0.011501563,-0.049127568,0.09359459,-0.0019340626,0.009934066,0.034259748,0.0068532065,-0.024466848,0.08678788,-0.01777088,-0.06484997,-0.005475974,0.03182807,-0.009323588,-0.09852168,-0.018054476,0.044932906,0.0044995025,-0.045470055,0.018223917,0.05428848,-0.07798256,-0.046580125,-0.016013982,-0.013903439,0.016391627,-0.058892485,-0.046129897,-0.07078985,-0.03299765,-0.026327765,0.019099597,0.057575017,0.017547483,-0.00070274615,0.04652119,-0.034078244,-0.02803794,-0.042689912,-0.12877218,-0.026694914,-0.047813654,-0.06621853,0.0047634146,-0.06730543,0.041836876,-0.037097473,0.20433226,-0.07898816 +3.4.21.49,"From the larva of a warble fly, Hypoderma lineatum. Little action on small molecule substrates of trypsin, chymotrypsin, elastase or microbial collagenases. In peptidase family S1 (trypsin family)",384,1.0,-0.026702683,0.045220323,-0.071366325,-0.056038607,0.04982601,0.069577836,0.0073710433,0.042468347,-0.024520595,0.027121246,0.05241469,-0.06975355,-0.057200808,0.12432237,-0.09076374,0.015908768,-0.08044403,-0.065615885,0.074054234,-0.047303222,0.034428265,0.11363971,-0.0038609821,0.01578657,-0.05718511,-0.015780976,-0.09884104,0.016648998,0.010673729,-0.05779382,-0.09472359,-0.0035653159,-0.054143418,-0.024758887,0.12712684,0.018078623,0.05798138,0.009000567,0.05620075,0.01864931,0.07619476,0.0056797024,-0.050077062,0.019707337,-0.018639205,0.0124464175,0.056434374,0.04993328,0.07548425,0.008909377,-0.062500544,-0.060108118,0.017394828,0.067697704,0.06325497,0.035134934,-0.030954156,-0.034823667,0.040119804,-0.08570159,-0.032705966,-0.006134127,0.095216274,-0.035115853,0.019191073,-0.06708828,-0.039002817,-0.0010524772,0.009903461,0.0033016023,-0.023032632,-0.005823344,-0.05842148,0.1289393,-0.054190725,0.08837944,-0.043043658,-0.064446725,0.014643961,0.020425837,-0.036823124,-0.047443643,-0.011323852,0.07920109,-0.06942916,-0.036769193,0.04876036,-0.04051679,-0.009523264,-0.047407184,0.04284716,-0.08107788,0.03357934,-0.018140547,-0.052242044,0.013071145,0.00042046822,-0.094500735,0.0068081166,-0.013288409,-0.04638285,-0.11380289,0.08439196,-0.04768193,-0.045737427,0.04033364,-0.034023196,0.0044803373,0.09325525,-0.0153161995,-0.08937478,0.014494446,0.007760637,0.039691806,-0.001990022,-0.027514271,0.0010971223,-0.069686525,0.0029574812,-0.014960632,0.050378833,0.0001676436,0.061392084,0.015272793,0.04240983,0.013145287,-0.090177596,4.3257435e-33,0.12070241,-0.036837813,0.027866535,0.024487521,-0.019678524,-0.079313315,-0.039041758,-0.014738859,0.010704204,-0.014953166,-0.11511064,-0.08013397,0.03603504,0.029512977,-0.021281896,0.049492687,-0.049243182,-0.059765793,0.0193284,0.052094664,-0.12006016,0.102429986,0.018194674,-0.11953573,0.120745055,0.056151945,-0.058349572,-0.028570168,0.017286072,-0.019042844,0.07301087,-0.038573056,-0.062804036,0.064562,0.06790447,0.040937923,0.07638171,-0.09700401,-0.079791844,-0.05115753,0.04832562,-0.005210928,0.021656945,-0.05271582,0.10095017,-0.0024003768,-0.07741589,0.026770912,-0.010703559,0.022450073,0.08767971,0.03460699,0.06729176,-0.057457995,-0.018842805,0.0016464178,-0.015353525,0.0041111405,0.03910131,0.04685159,0.024185825,0.0072424347,-0.00586256,0.038013943,0.073705286,0.0009810654,-0.071708605,-0.015396083,-0.044912238,-0.006279723,-0.022305219,0.027449323,0.053585306,-0.038695253,0.018846417,-0.06297122,0.041762352,0.013467095,-0.022764822,-0.008152783,0.05033305,-0.0743157,0.041428693,-0.042724304,-0.11311695,-0.03500417,0.04230447,-0.00793759,0.035652123,0.020527821,-0.008412004,0.012425141,0.0010375148,0.0352473,-0.06575895,-4.8404117e-33,0.020108264,-0.12749553,0.066528074,0.008805605,-0.04655324,0.09783852,0.019087821,0.05529514,0.005762335,0.03030212,-0.00648199,-0.0030442171,-0.005055717,-0.06946419,0.041088823,0.00058962655,0.037555538,0.026314845,0.058408268,-0.042756125,-0.057373572,0.03744729,0.05260762,0.02424701,0.044292655,0.03853984,0.038212225,0.03576883,-0.072359204,-0.062289968,0.006341678,-0.019134358,-0.017379288,-0.024226032,-0.030630633,0.0108715035,-0.031822048,0.018497208,0.07902067,-0.091511145,0.04243686,-0.009205352,0.016714051,0.02152435,0.004646038,0.056436937,-0.066470265,0.026458034,-0.02020356,-0.021492066,-0.019022454,-0.011327888,-0.0012537296,-0.015877236,0.04542745,-0.002325643,0.04236559,0.009222888,0.08031827,0.04472665,-0.014394746,-0.025393285,-0.06824088,0.05723646,0.084159255,0.066180766,-0.07711812,-0.049107745,0.06643787,0.022111746,0.08689636,0.0035790638,0.05227636,0.051951732,-0.017851518,0.04308399,0.013783374,-0.05138786,0.05532434,-0.0361782,-0.017089603,-0.017959392,-0.0055174935,-0.0008236449,0.026959013,-0.012373977,-0.011203955,0.065406546,0.0065409807,-0.0033012123,0.028545551,-0.02497005,0.005105837,0.04226893,0.039729092,-3.395183e-08,0.089749455,-0.026085557,0.07468608,-0.05154001,-0.049818188,-0.0046055582,0.06605222,0.026503926,0.0794151,-0.050220124,-0.009153592,-0.021626042,0.040059846,-0.0033012729,0.076861806,0.0024607943,-0.066851415,0.004744727,-0.06605059,0.013612276,-0.10602925,0.011909827,-0.07133712,0.07787245,-0.062013756,-0.04782413,0.03363977,0.074163556,-0.017771734,-0.072668396,-0.030279035,0.056443397,-0.007755209,-0.03221243,-0.03704865,0.0131512955,0.0055556456,-0.04825894,0.01982526,0.014732731,-0.018333247,-0.007274094,0.020398794,-0.12406795,-0.058010716,-0.027616002,-0.005903084,-0.009258134,-0.008563164,-0.08027853,0.033677712,0.007327157,-0.045168515,-0.049226902,-0.11349248,-0.026761709,0.06721893,-0.06319623,-0.004517434,-0.01358287,0.031420495,-0.0068422733,0.09467254,0.11277458 +3.4.21.50,From Achromobacter lyticus [6]. Enzymes with similar specificity are produced by Lysobacter enzymogenes (Endoproteinase Lys-C; [3]) and Pseudomonas aeruginosa (Ps-1; [4]). In peptidase family S1 (trypsin family),384,0.99999994,-0.10091599,-0.068722636,-0.14363602,0.004732684,0.07414576,0.074603125,-0.090690926,0.07515869,0.0037083733,0.026345776,0.04586033,-0.065231875,-0.0023015786,0.09164349,-0.06278085,0.046202943,-0.054087535,-0.06864808,0.0063046617,-0.033658892,0.038432878,0.05837087,-0.0877595,-0.023239048,-0.0027697477,-0.034088843,0.0107861385,-0.03207639,0.006188483,-0.008681251,-0.03889964,-0.10840408,0.06819529,-0.039636422,0.121786214,0.059334032,0.0063625826,0.013207184,0.12579623,-0.022284806,0.05329519,0.01783331,-0.024470478,-0.0560633,-0.024874067,0.009185826,0.01131099,0.082530715,0.040793933,0.009680207,-0.0588538,-0.035672188,-0.0010783074,0.0052563967,-0.031339325,0.0069220476,-0.0011140975,-0.04288962,0.020191213,-0.0013942057,-0.04366326,-0.026437271,0.04253152,0.013283469,-0.010085568,-0.052745145,0.013448619,-0.019352455,0.0029874053,-0.018472392,-0.068497874,-0.045372233,-0.033159643,0.14750217,0.0037207224,0.045515615,0.004836493,-0.0022602652,-0.057255547,-0.030938374,0.0058745607,-0.06720236,0.02094003,0.08969036,-0.028941669,-0.0558221,0.023824938,0.07298395,0.063830264,-0.024931325,0.005118742,-0.075735964,0.03422079,-0.062209804,-0.033562016,0.02511214,-0.008578083,-0.04908417,0.025531951,-0.086246826,-0.024530163,-0.054746795,0.08701645,-0.07222359,-0.0028645317,0.016193565,-0.045686413,0.059275754,0.09735635,0.00084729394,-0.016142229,0.028208088,0.04656517,-0.077464126,0.056815643,0.020046813,0.027068684,-0.048972197,-0.059640225,0.024056135,0.054461956,-0.00024341093,0.052887198,0.07338466,0.00042527617,0.045068853,-0.105141655,1.7136842e-33,0.02723281,-0.0052918326,-0.004661894,-0.039619662,0.0069814883,0.007264661,-0.042890865,0.047688566,0.03087759,-0.009452763,-0.07163253,-0.052752156,0.037354156,-0.02232781,-0.04085761,0.06288698,-0.042524647,-0.04839712,-0.004199631,0.06796023,-0.055654988,0.0705883,0.010277257,-0.0007312949,0.08423463,0.060034767,0.059223462,-0.034698963,-0.009047163,-0.024690177,-0.0038592585,-0.042890247,-0.09944487,-0.007453481,0.02957402,-0.004575826,0.048576538,-0.06427964,0.035760283,-0.027243052,0.044430237,0.06421156,-0.0421908,-0.022513874,0.10185343,-0.010696033,-0.07231656,0.061844602,-0.021446472,0.060749263,0.046053868,-0.068138786,0.064730816,-0.010262323,-0.047462076,-0.0100264335,-0.031139165,0.030292254,0.11355059,0.019446816,0.073363006,0.062878646,-0.032964937,0.008451343,-0.06512039,-0.043094803,0.020657623,-0.022254933,-0.0037722185,0.05890287,-0.06048767,0.0028417683,0.02267262,0.023526069,0.055707213,-0.09440265,-0.03728739,0.01665386,0.024797227,0.028203147,-0.008022082,0.021394892,-0.013137737,-0.037603572,-0.053417046,-0.06480541,-0.023980334,-0.026818128,-0.07411198,-0.04093533,0.0049328846,-0.037590727,-0.047370445,0.15116069,-0.056393832,-3.975682e-33,0.050895896,-0.13536258,0.054684646,-0.089343324,-0.04606004,0.029140815,0.030865468,0.006219272,0.014462736,-0.009706208,0.060710937,-0.04906003,0.023120562,-0.033429157,0.05062847,0.0016920517,0.008176913,0.06472208,0.019107321,-0.03125994,-0.0015649325,-0.009830381,0.040504247,0.012626759,0.083922885,0.044357102,-0.07364544,0.12462354,0.021688262,0.023484305,-0.009758317,0.022836007,0.004197593,-0.092868835,-0.07282589,0.026900155,-0.06243281,-0.00092487904,0.10449107,-0.05982404,0.12477041,0.048938416,0.048547484,0.10650971,-0.058097973,0.013274203,-0.02594384,-0.028030898,0.0010424211,-0.13461472,-0.024114387,-0.05885884,-0.023269182,0.029763548,-0.024976304,0.009070476,0.0039855805,0.054297168,-0.068441816,-0.017350629,-0.030667605,-0.037770867,0.015640685,0.08110058,0.03263335,0.08359716,-0.003870566,-0.015041081,0.028384803,0.0035072502,0.06366174,-0.009157575,-0.0057310406,0.016011413,-0.001155922,0.03975252,-0.05522015,-0.09218617,0.030103834,-0.072848424,-0.028455673,-0.029387765,-0.0032722175,0.028967425,-0.03704604,-0.05831179,0.012643803,0.06524419,0.042399544,0.040814128,-0.009187317,-0.0056251143,0.031526826,0.035081305,0.05967294,-3.6631043e-08,0.06626103,-0.05649592,0.12244593,-0.043505788,-0.021830784,0.019552084,-0.080235444,0.005410243,0.04139433,-0.03226691,0.011034727,-0.0027446405,-0.042657327,-0.015816135,0.06751302,0.018555015,-0.054203372,0.07789671,0.027495354,0.050358586,-0.04568394,-0.006196658,-0.031073866,0.03935706,-0.033530105,-0.025742324,-0.02076165,-0.057113595,0.026002508,-0.032072004,-0.052490756,0.023774302,-0.009497011,-0.04705553,-0.035902027,0.0033794611,-0.04776043,-0.09107994,-0.021887477,-0.032866307,0.017491419,-0.012146861,-0.0691007,-0.023349063,-0.012077664,-0.017236039,0.047498353,-0.055753767,-0.0055796844,-0.07261016,0.025383037,-0.050818883,-0.04143165,-0.05807701,-0.08753509,0.008306155,-0.05013869,-0.05003406,0.0055542127,-0.043021336,0.0232014,0.060770098,0.18030916,0.07399656 +3.4.21.53,Product of the lon gene in Escherichia coli. ATP hydrolysis is linked with peptide bond hydrolysis; vanadate inhibits both reactions. Type example of peptidase family S16. A similar enzyme occurs in animal mitochondria,384,1.0,-0.07456924,-0.02788373,-0.025946843,-0.07540098,0.06948827,0.04364987,-0.041382402,0.061216123,0.06275317,-0.06973005,0.093076445,-0.010731396,-0.027276518,0.047778502,-0.029712804,-0.007902016,-0.041967787,0.06836376,0.0069982465,-0.06045286,0.13420773,0.065623924,0.023286406,0.032521706,-0.015709238,0.027520902,0.14603302,-0.025098268,-0.02036671,-0.039455783,-0.007395054,-0.028594978,0.017531972,-0.033495888,0.08563657,0.05868319,-0.008958003,-0.022505218,0.056457717,-0.015238779,0.095761165,-0.004831872,0.039647073,-0.045784924,0.036565147,-0.04116904,0.030419996,0.029607773,0.029472036,0.012529289,-0.0030967635,-0.031713728,0.0037568272,-0.035166252,0.037817083,0.0046124384,-0.079144984,-0.06610683,0.0013534874,0.011576734,0.061061475,0.05082819,-0.01024802,-0.0041315225,0.04159009,-0.093989424,0.06974019,0.0032593005,-0.06467289,-0.06171386,-0.013097536,-0.086374745,-0.0313338,0.10069583,-0.072791405,0.007776256,0.05318262,-0.041089237,-0.011895125,-0.010770866,-0.013307536,-0.0393349,0.052137293,0.06523343,-0.010729,-0.016300336,0.047926832,0.030521529,0.024914602,0.002069041,0.0028845444,-0.07919564,0.031535868,-0.0457678,-0.04755833,0.008765547,0.027561843,-0.036144875,0.0020813323,0.029575983,0.02320857,0.054173395,0.025519082,-0.07042814,0.0023864491,0.06773381,0.006549929,0.059093624,0.023113092,0.03229965,0.007670443,0.031875316,0.019645195,-0.009990938,-0.04472589,0.031568915,0.0060270247,-0.05966588,-0.053998847,-0.010162938,0.0071442486,-0.062795006,0.03559072,0.07027207,-0.039760668,0.032589428,-0.10158947,3.763383e-33,0.007934146,-0.12487907,-0.026830006,-0.015573175,-0.019681603,-0.02607297,-0.04378341,-0.004115967,-0.047626402,-0.10013493,-0.10298573,-0.04682043,0.023930201,-0.041855346,-0.06840369,0.0014722303,-0.037422527,0.007703581,0.0966464,0.0053159334,-0.034404356,0.057545688,0.024778476,-0.042234153,0.05024956,-0.014893402,0.027845576,-0.043009028,0.092970066,-0.0017153411,-0.005998697,-0.051093705,-0.023473602,0.0047359127,0.021131502,-0.011179159,-0.025665874,-0.048866212,0.039782908,0.051995806,-0.051048964,0.03810947,-0.048223495,-0.054555994,0.064611055,-0.051791992,0.0010509116,0.046262063,-0.051816117,0.034936342,0.02671964,-0.03155018,0.04767982,-0.047173373,-0.02055641,-0.022478769,-0.016637526,0.011792074,-0.0026554824,0.086957365,0.026188903,0.11157827,-0.026039442,0.005038264,0.030748151,-0.016840138,-0.037076835,-0.06576594,0.049882475,0.07566437,-0.06169301,0.008038295,0.088369936,0.029386366,0.00741097,-0.084788665,-0.041849714,0.06486151,-0.033410653,0.09315299,0.036292184,0.033601403,0.052271217,0.006468855,-0.031924352,0.015088584,-0.02220006,-0.027719196,-0.06646857,0.027982611,0.10613632,-0.07378726,-0.035878308,0.044356797,0.041179337,-4.0617334e-33,0.049954027,-0.07838511,0.0584188,-0.11021614,-0.06718582,0.011241893,-0.022413842,-0.041025452,-0.020639362,-0.030714786,0.021938447,-0.049156897,-0.04843418,-0.08327742,0.036578793,-0.0066025406,-0.017382383,0.06021123,-0.046965517,-0.016840836,-0.016137995,0.09320586,0.06827025,0.037886783,0.018819151,-0.020946782,-0.013965347,0.09842488,0.006349274,-0.006286926,-0.050456513,-0.0097319875,-0.023802599,-0.043594465,-0.060029935,0.05793489,-0.00278403,0.03635648,0.009781909,-0.078775026,0.039992373,0.062276453,-0.003736346,0.073930904,-0.024881048,0.045509692,-0.044744525,-0.05397895,0.04655872,-0.054331057,0.0409597,-0.057233375,0.017022053,-0.03397081,0.07474659,-0.041073773,0.059566956,0.05090376,-0.041990917,-0.013387786,-0.010612847,-0.04649862,0.038073428,0.0074511855,0.029793218,0.05613539,-0.1684055,0.02111722,0.051629234,-0.0026055481,0.033946525,0.06650625,0.010932179,0.020020815,0.028387558,0.046386223,-0.045622885,-0.049534068,-0.013766344,-0.039794914,-0.039877888,0.040421564,-0.09113642,-0.06037277,-0.010748946,-0.065252334,0.05639472,0.10157252,0.023702478,0.028532028,0.056146618,-0.042265702,-0.035908177,0.07832909,-0.0016461371,-2.993783e-08,0.0059995526,-0.12572986,0.05354605,-0.049746882,-0.056502033,0.071322605,0.062063348,0.063422784,0.07092843,-0.030263832,0.029422017,0.1176614,-0.017157974,0.020871338,0.079943895,0.037100844,-0.057651844,0.027730113,-0.03476738,0.00040624817,-0.0054418766,0.022880008,-0.070648804,0.12137774,0.031514227,-0.052560754,-0.020296404,0.029847922,-0.02703106,-0.09246585,0.0017272504,-0.06006178,-0.030954717,-0.045641698,0.035325278,-0.02071809,-0.012537239,-0.0066215834,-0.01708761,0.029463066,-0.01353556,-0.03781523,-0.103475355,0.007755156,0.03443253,0.055185694,-0.020532444,0.033820983,-0.012230506,-0.019079072,0.02570885,-0.047151722,-0.0038193408,-0.114621356,-0.115240745,-0.019988716,0.030348016,-0.09934114,0.043717172,-0.031991534,0.079909496,0.006241683,0.20211473,0.058942143 +3.4.21.54,"A member of the tissue kallikrein family, from submandibular glands of male mice. In peptidase family S1 (trypsin family)",384,1.0,-0.07447354,-0.024007086,-0.07551843,-0.03430623,0.026298463,0.022589883,0.051061094,0.03127008,-0.008028518,0.05196384,0.038796294,-0.06758163,0.023478659,0.1082921,-0.022209467,-0.0121351965,-0.087345354,-0.035318635,0.05138505,-0.06419941,-0.025164131,0.023737034,0.019595675,-0.017574752,-0.06909373,-0.0351301,0.00016268382,-0.035323244,-0.019506015,0.046781197,-0.045213632,-0.10853749,0.005291376,-0.06583856,0.058340877,0.008009495,-0.05444511,0.058156557,0.08178886,0.007678171,0.01674815,-0.050064374,-0.0505194,0.007748624,-0.027822344,0.08071472,-0.024795474,0.0952509,0.061257623,0.03154892,-0.024285419,-0.10618431,0.048676744,0.016191293,0.06234064,0.057221815,-0.0979107,0.0032917338,0.020755095,0.09014524,0.00010089176,-0.042883947,0.045650877,0.01350657,-0.016413532,-0.041265354,0.028940067,0.029770441,0.010746944,0.029977083,0.06280701,-0.03382432,-0.07654687,0.101663575,0.009456801,-0.01768164,-0.0325799,-0.011785916,-0.01222914,-0.016401242,-0.024609167,-0.008686118,0.051547006,0.07885091,0.004867504,-0.058245923,0.053561263,0.008157511,-0.09261234,-0.04206831,0.00023563007,-0.096934035,0.020304348,-0.028334223,-0.0024845395,0.026945973,0.0033097274,-0.00030663103,-0.006799423,0.03961191,-0.043041088,-0.0771025,0.06318583,-0.0664005,-0.0048067453,-0.013745708,-0.09179429,-0.030712744,0.07999368,0.013884185,-0.041900724,-0.055303033,-0.002295347,-0.040169958,0.08942876,-0.049783193,0.038447205,-0.0077492436,-0.032466456,0.054373883,0.05817595,0.029030994,-0.008989591,0.04371474,0.0069144964,0.048490968,-0.03877448,-6.7930177e-35,0.029504888,-0.031956036,0.038219374,-0.0060688015,-0.0023977244,0.034165666,-0.0022470134,-0.0005156916,-0.06475563,-0.06136297,-0.06930119,-0.13112764,-0.021000084,-0.01695558,-0.015370514,0.05344038,-0.09195171,-0.036395695,0.06973504,0.013434857,-0.07170828,0.095216885,-0.0066057798,-0.009687785,0.014483226,0.016408881,-0.06668571,-0.05745349,0.05010812,0.006263514,-0.050731596,-0.0010403967,-0.09839134,0.000544867,-0.10163922,-0.012402928,0.0240677,-0.100360945,-0.03462462,-0.018063607,0.041942384,-0.00029078108,-0.0241234,-0.07306498,-0.0002702137,0.021090385,-0.08607239,-0.022000095,0.004599559,0.036968213,0.068733595,-0.037117302,0.040035278,0.026066173,-0.055945925,0.019996475,0.0028812564,-0.0030530177,-0.0065141283,0.0409091,0.05138712,-0.033522666,0.08315709,0.006886258,-0.002491929,-0.033499476,-0.048622333,-0.035555877,-0.050933547,-0.01480938,-0.0040010274,0.011728675,0.05427842,-0.071811885,0.03167046,-0.01949622,0.036583137,0.13807254,-0.06309287,0.079314396,-0.025961462,0.02761969,-0.034155153,0.019144226,-0.031541977,-0.06064335,0.02603133,-0.0028658968,-0.0060992213,-0.062840246,-0.022632513,-0.0489492,-0.08198998,0.074331746,-0.069042735,-2.8337732e-33,0.048840016,-0.037316658,0.11856279,-0.02357928,-0.028893577,0.10102388,0.084299825,0.04445084,0.032075904,0.027030306,0.030000603,-0.078211285,-0.016048452,-0.011707322,0.04832239,0.039804995,0.015402658,0.092938125,-0.0077275545,-0.0775798,-0.045989983,0.01530274,0.022277318,0.039745547,0.074154116,0.02264322,-0.045775667,0.014596741,-0.035627794,0.06561892,-0.015925206,-0.0088379225,-0.096395634,-0.027358647,0.054848827,-0.048484392,-0.073522285,0.001681655,0.017167157,-0.035802588,0.030996887,0.11702069,0.099809565,0.09697625,0.016521737,0.055497874,0.02089189,0.020757085,-0.038133774,-0.07320525,-0.034888387,-0.02904119,-0.03084745,-0.004438796,0.0049718935,0.041987047,0.050660584,0.08218241,-0.017694496,-0.009072872,-0.079622805,-0.070621215,-0.054244094,0.09076625,-0.030007334,0.024784671,-0.0794087,-0.04125169,0.023515904,-0.01892595,0.063911386,-0.054873675,0.095786795,0.053311646,0.03117745,0.025440514,-0.02960478,0.04359172,-0.0024084644,-0.013819221,0.0041276645,-0.026660275,-0.010905082,0.033619713,-0.005171317,-0.11863689,0.027351571,0.030213518,0.08012334,-0.039846137,0.0033516695,0.05891775,-0.020879468,0.05731642,0.078498274,-2.8882237e-08,0.12338975,-0.10022852,0.010019061,-0.092516795,0.021647602,-0.043453068,-0.041248854,0.066763714,0.01146337,-0.014969858,0.026278084,0.027799534,-0.037352696,0.0007692386,0.035644308,0.062476356,0.01329654,0.028044544,-0.0023607006,-0.04226188,-0.09540061,-0.024563061,-0.0293854,-0.0053375186,-0.027584316,0.015538551,0.0021124869,0.059105158,-0.04649069,-0.06491753,0.073432796,0.0403119,-0.10229048,0.03259609,0.039256725,0.027336696,0.018855097,-0.0331523,0.010551678,0.020618966,-0.07208219,-0.10534753,-0.0117558185,-0.057067055,-0.047446847,0.030617649,-0.021763297,0.09970244,0.014035452,-0.047905624,-0.056125306,0.021902084,-0.047076467,-0.022329696,-0.053268425,0.006679934,0.0046846345,-0.04583012,0.03991233,-0.054424435,-0.0025392019,0.107928686,0.16476691,0.093238264 +3.4.21.55,"From the venom of the Gaboon viper Bitis gabonica. Activates Factor XIII. Not inhibited by antithrombin III/heparin or hirudin, unlike EC 3.4.21.5, thrombin",384,1.0,-0.10650842,0.019618891,-0.08298073,-0.03642806,0.050891936,-0.01635632,0.015833758,-0.0032675266,-0.027723026,0.04470918,-0.00034986576,-0.041066032,-0.045363016,0.01619869,-0.009997487,0.0043839593,0.07475316,-0.008257894,-0.053268883,-0.06813059,-0.027798064,0.051329672,0.04947363,-0.005057605,-0.050799232,-0.019017639,-0.102480285,-0.0149777625,0.12989715,-0.048357043,-0.044798404,0.054753244,0.031096963,-0.09309097,-0.03964583,-0.049713984,-0.0014900882,-0.018619938,0.002098863,0.029499773,0.1195408,-0.0047869887,0.016884256,-0.01903796,-0.010032054,-0.051561657,-0.079322256,0.08580115,0.060761865,0.056593623,-0.01363657,-0.0010342236,-0.0632184,0.012647906,0.020842422,-0.061394237,-0.09525263,-0.096063636,0.00919893,0.012148131,0.005426028,0.055754207,0.03464245,0.04244153,0.021858819,-0.043931324,0.07564377,-0.056510918,0.0057696756,-0.0008332998,0.027119258,-0.047909286,-0.044243068,0.049370512,0.046169043,0.04472773,0.07546255,0.041023362,0.01512491,-0.06610733,-0.051528603,0.03955392,0.15062623,0.14113718,0.016015952,-0.0026507666,-0.05407937,-0.005042564,-0.0013167929,0.0826398,0.102613054,-0.04251848,0.039373398,0.0044289688,0.033436663,-0.0001925304,0.029192677,0.0023915637,-0.013773037,0.049363017,0.013309975,-0.00039943177,-0.10538672,-0.013427998,-0.0129894735,-0.008594028,-0.043210447,0.05021464,0.022873936,0.0111495545,0.00768809,-0.09320596,0.105173625,-0.05700532,-0.018231014,-0.0039617526,0.029384438,0.04094268,0.02988741,0.0026825948,0.060842138,0.02351761,-0.00035945402,0.0073145335,-0.008478813,-0.03191292,-0.12516086,1.8709499e-33,0.07227,-0.03035949,0.06589925,0.022593185,-0.06927941,0.054234587,-0.093060926,-0.022776293,-0.084784,0.031001123,0.0038741585,-0.07524368,0.032944,0.09552757,0.021252044,-0.03772123,-0.01989319,-0.08543189,0.021895342,-0.05147397,0.08783374,-0.022766247,-0.06969996,-0.032607816,0.026097301,0.08863529,-0.039449196,0.040712036,0.027934015,0.052002504,-0.069464535,-0.08773268,-0.0050208047,-0.012031477,-0.07535922,-0.051799286,-0.021063577,-0.06795683,-0.013117253,0.04700987,0.04103067,0.0075044977,-0.13650101,-0.08046083,0.035030402,-0.084566325,0.013613411,0.055173565,0.02464922,-0.013725737,-0.011237794,-0.0567422,0.1181758,-0.051725622,-0.036253758,0.051919788,0.014951392,-0.0025710985,0.0012048095,-0.03533505,-0.027998824,-0.001045872,0.012797646,0.09434582,0.022594552,-0.029461924,0.041110814,-0.12828265,-0.030086033,-0.066958144,-0.022759838,0.020420277,0.084557,-0.057690393,0.010954727,-0.008463565,-0.05562808,0.050806344,-0.023178516,0.0068096337,-0.04440822,-0.017621681,0.014229745,0.05152171,0.033246897,-0.022002382,0.037021313,-0.05370985,0.016811978,-0.022400033,0.053233407,-0.083051614,-0.0046414416,-0.039259598,-0.0021601368,-1.7496102e-33,0.029929949,0.024885332,0.06398891,-0.024768353,-0.029405726,0.007871284,0.006573018,0.028806724,0.048532035,-0.0115736155,0.092932865,0.012321408,-0.06114911,-0.012565425,0.04341123,0.030757172,-0.0019267374,-0.012145228,-0.023933213,-0.024647208,-0.03860855,-0.122190244,0.02889849,0.01457773,-0.0036147134,0.041040257,0.009436639,-0.015961474,-0.032933176,0.024308207,-0.10637176,0.032707065,-0.04651078,-0.04774235,0.012104022,-0.0030814253,-0.009549852,0.026763633,-0.023520932,-0.10999914,0.054613717,0.082287066,0.08691121,-0.012753885,0.009519113,0.11405383,0.012110788,0.049522743,0.012536348,-0.009017229,-0.0069736484,0.012039278,0.052821327,0.10596129,0.0014283637,0.002215671,0.054395832,0.0049798083,0.018349465,0.049234428,0.063508555,-0.013841072,-0.025509894,-0.021115985,0.07299017,0.10889382,0.00507225,0.09071671,0.048466116,-0.079838626,0.0709385,-0.02900656,0.039461985,-0.02857518,0.005088774,0.0382398,0.052754093,-0.02520814,1.9405728e-05,-0.044908684,-0.012457464,-0.041137315,-0.07052295,-0.046138838,-0.010023714,-0.008519425,-0.041235663,0.09548334,0.034746032,-0.007581681,-0.068845496,-0.018530164,-0.0042689755,-0.029506363,0.033072185,-3.000799e-08,0.06061936,-0.047952343,-0.05372874,-0.047262087,-0.029888898,0.077771686,-0.049677316,-0.01167317,-0.013857708,0.091888696,0.083943546,-0.015636051,0.04643486,-0.07909395,0.106271505,0.017145902,0.017099531,0.0035785749,-0.024060857,-0.14155363,0.03884933,0.013572155,0.029816147,0.009418594,-0.04406108,-0.08510135,0.0036999749,-0.03764893,0.02346422,-0.05349494,-0.05822592,0.060893547,0.0070968694,-0.01692053,-0.060580984,0.042740993,0.032498967,-0.04095168,0.07342662,-0.031154204,0.047198582,0.030644402,-0.06315675,-0.054114692,0.01087119,-0.03418407,0.06587265,0.061034407,-0.03567757,-0.056254942,-0.053937435,0.072311684,0.022364566,-0.027374139,-0.077705555,0.005530934,-0.025875967,-0.028072227,0.044385005,-0.00084278977,0.058913264,-0.06817498,0.08004787,0.009166919 +3.4.21.57,From leaves of the spinach plant (Spinacia oleracea),384,1.0,-0.05648356,0.04957788,-0.12604049,0.032163545,0.038533118,0.033186186,-0.06721711,-0.018799052,0.037230648,0.010323769,0.10711075,-0.001498708,0.016418317,-0.14817199,-0.046486642,0.04053372,-0.020234378,0.04990448,-0.11462231,-0.017272433,0.059425376,0.009826998,0.05396772,0.010054478,-0.053581484,-0.003912744,-0.016826002,-0.019877885,-0.0017377811,-0.0812084,0.011158859,0.06264049,-0.0040836353,-0.08568701,-0.03266695,-0.008135544,-0.041594215,-0.09533128,0.10798922,-0.066928156,0.046944063,-0.028978618,0.045302343,-0.008793291,-0.037792053,-0.008656272,0.01190748,0.039817594,0.1267741,-0.01877973,0.013050742,-0.04043278,-0.06292483,-0.03241476,-0.040188216,-0.036166694,0.04004679,-0.05043526,0.03533128,0.11530364,0.074079335,-0.0023295446,-0.08629071,0.038770553,0.010880371,-0.050126806,0.001111607,-0.06668141,0.025632814,-0.112438984,0.0048542204,-0.03577154,0.02830195,0.08044848,-0.0098025445,0.01051766,-0.006475283,-0.019915443,-0.036068138,0.022055414,-0.07749051,-0.013156173,-0.046998944,0.07874113,0.0045767208,0.03584985,-0.010516433,0.040629614,-0.0063179624,0.073704034,0.031898525,0.082960136,-0.074635915,0.012526157,-0.019431202,0.05344616,0.046525553,0.015507518,-0.010556749,-0.004706968,-0.022324009,-0.04351667,-0.003330381,-0.09882895,-0.15431084,-0.05836583,0.0230319,-0.08408324,-0.08167221,0.018168086,-0.02389831,-0.03557765,-0.09533342,-0.045100648,-0.054381132,-0.0503423,0.052077487,-0.040052265,-0.000580832,0.015507559,-0.046469785,0.04454362,0.040245615,-0.006505343,-0.021236701,-0.065702364,-0.030501192,-1.3467413e-33,0.058802374,-0.007901118,0.016319755,-0.01834045,0.06345313,0.011702947,0.017904745,-0.07382098,0.042730756,0.003351556,-0.11070256,-0.041954614,0.016026497,-0.120142,-0.01567789,-0.024950853,-0.0038467674,-0.059308592,0.025411552,0.01546479,-0.023970619,-0.014506362,-0.024562797,-0.008678469,0.015996058,0.015577737,-0.013899053,-0.090584375,-0.054828145,0.014516337,0.09808286,-0.028960299,-0.039419662,0.023114163,0.07089532,0.01769192,-0.022247743,-0.04974194,0.024766605,0.020610379,0.056149613,-0.03320142,0.06580274,0.106873795,-0.047106277,0.055168513,-0.045997713,0.041599534,0.07599014,0.033049606,0.05166598,-0.013475506,0.048467837,0.0073480345,-0.061309062,-0.007862,0.0451955,0.030669898,0.011051704,0.06307766,0.0069196606,0.14565767,-0.0077577136,-0.01872629,0.028557118,0.031948242,-0.11587023,-0.032522853,-0.023487875,-0.09014129,-0.0020748267,-0.097900815,0.017882241,0.00987478,0.06629367,0.05620235,-1.9125458e-05,0.07598095,-0.0027699706,0.017097805,0.041915677,-0.030571174,0.0020305132,-0.03938908,-0.053578462,0.094089374,-0.094044104,-0.040996302,0.027231086,0.024758486,0.0446648,0.038588103,0.025366219,-0.053008772,-0.021446066,-1.7532109e-33,0.045513574,-0.029449303,0.057133783,-0.008620347,0.067616075,0.01437084,-0.12389394,0.0014908689,-0.045646656,0.038341824,0.039844327,-0.021831747,0.023597142,0.018550348,0.0024009745,0.04163689,0.10116113,0.09309512,0.018849539,-0.028249793,-0.08663488,0.06718881,0.011261588,-0.06203051,0.056654476,-0.057176404,0.09853283,0.03625331,0.013141665,0.010564354,0.068452574,0.011552375,-0.061308227,0.0090377545,-0.03802396,0.034073856,-0.020117987,-0.08081195,0.060747888,0.086317286,-0.033157807,-0.05078452,0.07108133,-0.009547596,0.016278496,-0.057681326,-0.015717786,0.037582997,-0.0557817,0.0018766443,0.13357143,0.014529395,0.014101723,0.0075149997,0.075850725,0.05335545,0.025957515,-0.026257068,0.08759145,-0.09319639,0.03345629,-0.0212315,-0.0701594,0.021379292,0.009491691,0.03968984,0.005267072,-0.031131715,-0.010164493,0.06848318,0.005719664,-0.0029928011,-0.037541848,-0.03677188,-0.069314666,0.06913793,-0.0024152007,-0.0065660677,-0.023819083,-0.0022944172,-0.037581313,0.05980778,0.039062373,-0.069360435,0.053274788,-0.06344387,-0.03167571,-0.03311529,0.020825492,-0.0013308428,-0.05223517,0.0048855855,-0.05463014,0.051300246,0.07596938,-1.7992816e-08,-0.0055114594,-0.026648333,0.01996055,0.072916105,0.070811115,-0.04669038,0.024462564,0.0024973466,0.082012005,0.005637594,-0.012380904,0.049334764,-0.0057029203,-0.04403443,0.07324554,-0.006082387,0.0347529,0.07690519,0.05072352,0.0721367,0.031018604,-0.052747045,0.004693893,-0.043164212,0.006094227,-0.008673319,0.05283925,-0.02791381,0.006469982,-0.030700479,0.08558093,0.026256843,0.0434477,-0.11208555,-0.08440878,-0.032251865,0.013373242,-0.0306535,-0.052360512,-0.010856482,-0.04652153,0.014643872,-0.01567574,0.01794257,-0.05276703,-0.039152734,-0.007581991,0.10043786,-0.025459439,-0.07287173,0.018779207,0.017057573,0.041134927,0.028140374,-0.013313131,-0.05602258,0.051435955,-0.025845453,-0.013975612,0.0682637,-0.07144106,0.0380302,0.08665579,0.020399353 +3.4.21.59,"Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. In peptidase family S1 (trypsin family). Not inhibited by alpha1-proteinase inhibitor or alpha2-macroglobulin",384,0.99999994,-0.020523854,-0.067741446,-0.10175549,-0.02638536,0.049982037,0.08412194,0.03245698,0.1102032,9.832349e-05,0.062103525,-0.0032646211,-0.017648803,-0.04652961,0.14370452,-0.020322427,-0.06293061,0.011761629,-0.046435576,0.009579442,-0.10041375,0.024536347,0.016430095,-0.0087061515,0.013752631,-0.053080257,-0.05629281,-0.049901403,-0.01029416,0.047349304,0.0062113726,-0.026210414,-0.06608571,-0.007662009,-0.04738929,-0.0027029559,0.009636305,-0.020217663,0.019968882,-0.0017242527,-0.017150415,0.119293444,0.0061389324,-0.010373232,-0.029840065,0.0039189854,0.016983373,-0.0073147365,0.12519373,0.10967094,-0.0102532385,-0.014404708,-0.09435708,0.061838254,-0.010789732,0.011288047,0.043584336,-0.018808927,-0.0519777,0.08652149,0.076865435,-0.066055626,-0.01309847,0.066092126,0.020086262,0.10110144,-0.068874225,0.017984206,0.037347525,-0.084512815,0.06764302,0.020482397,-0.019883558,-0.047380194,0.17689453,-0.011003281,0.016572408,-0.03670442,0.010409437,-0.0018563663,0.011815859,-0.04323207,-0.04243399,0.054595333,0.15716274,-0.06439691,-0.010648507,-0.056424525,-0.02513825,0.023514587,-0.038017906,0.026354369,-0.042552814,0.055511814,0.0076877754,-0.022868894,-0.0050746473,-0.074155375,0.007377035,-0.009316907,-0.016607001,-0.030492162,0.012890513,-0.05397626,-0.08167893,-0.0417145,0.022771198,-0.08375635,0.009325095,0.037220426,0.05931193,0.015473845,-0.025750138,0.050222598,-0.061909407,0.021599505,0.017734274,0.044979323,-0.0012616941,-0.0009054572,0.01612823,0.03449162,0.00088555174,0.042139146,0.061881516,-0.007915272,-0.022169275,-0.03897352,1.3451163e-33,0.04071111,-0.08535154,0.041377332,0.05567482,-0.067619145,0.03228257,-0.037080463,-0.053735167,0.028621448,-0.04162984,-0.063790165,-0.063088536,-1.9936295e-05,0.027811274,-0.0287732,-0.026376806,0.010614528,-0.06532499,-0.039097216,0.0159436,-0.041923784,0.10655804,0.010768145,-0.028823847,0.025442192,0.08619784,-0.07292068,-0.050668083,0.07494776,-0.015341865,-0.007750687,0.050260663,-0.13830735,0.06365429,0.00091003213,-0.044950686,0.0037301136,-0.039920077,-0.032045178,-0.002122655,0.014830654,0.0027958704,-0.014103218,-0.08326408,0.03011608,-0.07839018,0.03570418,0.004178128,0.011516209,-0.026030092,0.122259825,-0.041882735,0.03607971,-0.054045927,-0.06483044,0.020114886,0.015931766,-0.0045693307,0.039850075,0.052474685,0.053925242,-0.047820095,0.009891229,0.090792984,-0.00217473,0.049008843,-0.015386416,-0.090450756,-0.049402393,0.06004337,-0.029870875,0.028053204,0.116857514,0.0060692765,0.028587416,-0.05304345,0.029047111,0.118701436,-0.03665311,0.049138762,-0.02254444,-0.09780331,-0.01708112,0.05262295,-0.07256502,-0.048546642,0.022148332,-0.0064626425,-0.0446271,-0.021572534,0.0050793584,0.009955039,-0.07426989,0.06275937,-0.0442594,-4.5363892e-33,0.00189322,-0.04841286,0.09117857,-0.04794499,-0.061819516,0.036153667,0.013574186,0.019428164,0.06761988,-0.022726284,0.054833237,-0.10713953,-0.013446068,-0.024174053,-0.031655073,0.03678691,-0.014202881,0.08965936,-0.09043327,-0.08171279,-0.08333611,0.0022278668,0.071523786,0.0242117,0.048144173,-0.03356118,-0.065039635,0.035075106,-0.019854251,0.015863065,-0.03347718,0.048917342,-0.087035,-0.041324906,-0.014868121,0.016086059,0.0025850604,-0.03506636,0.013103732,-0.14292218,0.035415187,0.07781425,0.09498226,0.07024146,0.019532245,0.088029556,-0.07773604,0.04178322,-0.047297154,0.016864607,-0.07423451,-0.039953493,0.05799672,0.009112902,0.02753613,-0.022366462,0.058302566,-0.013238744,-0.026020799,0.052703924,0.024732133,-0.03028462,-0.025094265,0.048693776,0.038988646,0.020751948,-0.059114974,-0.022826534,0.053766116,0.061671723,0.048993465,-0.06546498,0.041823775,0.016362341,-0.0641694,0.078235544,-0.017246362,-0.05356201,-0.011859074,-0.066633336,-0.0524035,0.015350423,-0.028414348,0.008566045,0.048068963,-0.05657761,-0.014199303,0.08788463,0.06502101,0.033983015,-0.044340663,0.00017916688,0.044364054,0.040944826,-0.0059591243,-3.4295084e-08,0.12612283,-0.06387484,0.034760404,-0.066500746,-0.05323533,0.04534562,-0.09148357,-0.025104787,0.029183822,-0.03664922,-0.033503022,0.01290906,-0.009637726,-0.026621746,-0.010425743,0.028490935,0.005781828,0.0053080465,-0.00040951907,-0.007198489,-0.03144195,-0.059287425,0.012646763,0.019734351,-0.06463962,-0.034149084,-0.04040184,0.10430995,-0.016723568,-0.057291027,0.007601958,0.03354219,-0.019796757,-0.020938694,-0.03145165,0.111514896,0.005896166,-0.047654066,0.0222036,-0.008601983,0.022014102,0.03094595,0.0030873013,-0.062448278,-0.029497396,-0.009344278,0.011199899,0.02625119,0.050701972,-0.03411112,-0.039040048,0.058611404,-0.04946097,-0.037096344,-0.051677316,-0.035282735,-0.015577352,-0.057529014,0.09703914,-0.036346264,0.0355401,-0.025885213,0.08114965,0.050572533 +3.4.21.60,"From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca2+ which binds via gamma-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis. A member of peptidase family S1.",384,1.0,-0.05502137,-0.0103328945,-0.13219056,0.0084429765,0.022857944,0.030645305,-0.005100868,0.0709256,0.012787901,0.004212758,0.05131622,-0.0672785,0.025415903,0.12484905,-0.0026902147,0.049354665,3.4196724e-05,-0.007287342,0.0027175995,-0.08555552,0.0525841,0.07127095,0.048994713,0.03504708,-0.03226954,0.013341951,-0.04085417,-0.046346847,0.047445286,-0.036408994,-0.08116821,-0.0066177207,-0.005835307,-0.1290293,0.038625166,0.0010726742,-0.029784698,-0.02426137,-0.02084287,0.015107075,0.12828928,0.07574876,-0.026202599,-0.006063127,-0.037677974,-0.043282554,0.0105925845,0.090541236,0.02276315,0.07118163,-0.0027910632,-0.05357777,-0.08243854,-0.013330978,-0.0014959582,-0.053313173,-0.057598054,-0.08864669,0.025652148,0.029816005,0.005626779,0.07042835,0.06393114,0.06824361,0.0216705,-0.1024235,0.019334255,-0.017093321,-0.02011726,-0.0415655,-0.022548053,-0.074240424,0.014596481,0.07239985,0.015202079,0.017369036,0.080560125,-0.041637722,-0.038318668,-0.021956854,-0.06669654,0.047071762,0.09134602,0.10337853,0.058034208,0.053940397,-0.003817478,-0.012300102,-0.008930227,0.034228,0.101989865,0.027574172,0.060095407,-0.004737623,0.037502315,0.016105285,0.049598094,0.043641184,-0.058813207,-0.0012636947,0.016766205,-0.043787926,-0.06675033,-0.034994233,0.017314265,-0.040795695,-0.055448882,0.012551617,0.041742366,-0.006438268,0.041378923,-0.05641355,0.047197007,-0.014099564,0.025905777,0.045734987,-0.008105984,0.032060716,0.0027876918,-0.028712723,0.011460181,-0.030453416,-0.007726504,-0.031612653,0.07585739,0.025007673,-0.16362748,5.096723e-33,0.03323619,-0.016617937,0.020472465,0.008632192,-0.022882512,-0.023230944,-0.06308688,0.00869513,-0.03129906,0.04368811,-0.042170454,0.011812795,0.018671524,0.049573306,-0.06858748,-0.04644447,-0.027348049,-0.044656552,0.03914137,-0.008050068,0.040535327,-0.024768883,-0.02029865,-0.008780917,0.0007795795,0.055201013,-0.026560768,0.00084211625,0.052452024,0.03070586,-0.09487152,-0.13200548,-0.06352724,0.033941604,-0.060248733,-0.05484627,0.07536635,-0.08017219,-0.08038023,0.04375691,0.023460096,0.0055547035,-0.06506087,-0.09564273,0.006617617,-0.08602199,-0.07392305,0.07478135,0.027904117,-0.000861881,-0.015291234,-0.046606448,0.17510274,-0.0033249282,-0.046045154,0.027148953,-0.033929672,-0.0071158907,0.025488846,0.0073890984,0.013917018,-0.023774534,-0.012227742,0.035662998,0.0730509,-0.0011115386,-0.0224581,-0.11128326,0.014108912,-0.028126989,-0.022759415,0.06941418,0.025643004,-0.018365648,0.05326938,-0.08446868,-0.051249646,0.068117626,-0.053220224,0.06363032,0.005162634,0.005073288,0.08184294,-0.018109191,0.025225906,-0.028944302,0.088022426,-0.033592083,0.015562976,0.018762402,0.0450336,-0.05635902,0.015443104,-0.04148484,0.010101336,-3.8729644e-33,-0.02311871,-0.01778167,0.06930755,-0.044483166,-0.02203611,-0.012114632,0.0093609,0.057764176,0.05483011,-0.04984585,0.041569706,0.06923926,-0.0075994576,-0.035913117,0.011356474,0.054362234,0.032332614,0.02943218,0.0028164445,-0.084213406,-0.07108073,-0.000877156,-0.003923953,-0.03610142,0.0654473,-0.002272691,-0.035128385,0.012360613,-0.021972433,0.0055482658,-0.09017428,0.06162127,-0.051718943,0.005895986,-0.0841657,-0.06348752,-0.038230848,0.003203345,0.02733444,0.03333902,0.047518667,0.05794551,0.011341158,0.035132114,0.017846419,0.081167005,-0.043812707,0.04751814,0.014635716,0.0075071747,0.021425314,0.022755625,0.014495932,0.061243825,0.03249602,-0.010445889,0.05295583,0.054324497,-0.00826794,0.0011289567,0.009437427,-0.06070679,-0.038102068,0.009709947,0.07003982,0.116408706,-0.017886795,0.048670433,0.020951198,0.0025309382,0.14291732,0.01967264,-0.040817723,-0.057464756,-0.012928842,0.047381666,0.0074547664,-0.03957641,0.014818186,-0.021444654,0.046169862,0.0074108667,0.028826566,-0.0432189,0.022411646,0.043927737,-0.031794403,0.09736961,0.028363507,-0.018925346,-0.033046987,-0.11118064,-0.017316716,0.04133433,0.08049173,-4.2353175e-08,-0.05794261,-0.06165319,-0.047826502,-0.032573756,-0.035617102,0.057094414,-0.024722014,-0.042208586,0.06638454,0.03268848,0.035196986,-0.020585947,-0.00753245,-0.018674513,0.042810593,0.048240677,0.058616724,0.093280606,-0.01134594,-0.086831585,0.0065387487,0.009794435,-0.03571603,0.05557436,-0.049293343,-0.08366448,-0.00699873,-0.008189744,0.05495591,-0.045309328,-0.11038341,-0.00795528,-0.056566972,-0.052339405,-0.09860146,-0.034281578,-0.0015682492,-0.01913073,0.04156934,0.030002141,0.07424547,-0.10730649,-0.055595722,-0.03575333,-0.029874396,-0.002934267,0.051256705,-0.027135702,-0.007985891,-0.07950604,0.03983158,0.034226835,0.03573059,-0.10428227,-0.10647106,-0.006784143,0.014032025,-0.01109427,-0.05516772,-0.017563004,0.027912779,0.028019503,0.20742531,-0.017011065 +3.4.21.61,"A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals.",384,1.0,-0.047804657,-0.008677595,-0.06970379,-0.03818438,0.059855476,0.087050885,0.01315812,0.09558511,0.06414959,0.102057815,0.061186135,-0.008910745,0.031814076,0.08980196,0.010813455,-0.02582815,-0.052111465,-0.01210106,0.045315895,-0.09374203,0.06261956,0.05832102,0.023115143,0.07641703,-0.09860294,0.0111815985,0.010498297,-0.02671357,0.0056037903,-0.008954686,-0.0010787428,-0.027292525,0.11021708,-0.06894856,0.064591296,0.0027712581,-0.019142525,0.021585576,0.003674061,-0.022538174,0.04851958,-0.004721693,-0.005811192,-0.04713876,0.038329627,-0.03910976,0.042158395,0.026911682,0.06454055,-0.059861276,-0.013342582,-0.059090976,-0.02618787,0.008136008,-0.033235114,0.06886818,-0.022623833,-0.024184728,0.06219029,-0.06382366,0.021096101,0.010775233,0.041309785,-0.0010708969,-0.008799904,-0.03467391,-0.026606191,-0.0136414915,0.0036160888,0.036519326,-0.03993063,-0.04543679,-0.07228558,0.06895492,-0.016029647,-0.014595414,0.028545117,-0.07056047,-0.04907409,-0.034733713,-0.004325767,-0.05285894,0.069965966,0.046460133,0.049057912,0.019591078,0.04079106,0.02268744,0.04988551,-0.07477161,0.052997302,-0.054786455,0.081134,-0.0020122016,-0.048863426,-0.010717091,-5.749685e-05,-0.034768302,0.03561664,-0.019022826,0.09475171,-0.015328774,-0.05559332,-0.06296231,0.014541478,0.13872512,-0.07532805,0.050692473,0.028665526,0.004463686,-0.016944494,0.007736603,-0.004421736,-0.048432227,0.0077107074,0.085316986,0.048647765,0.021546584,0.04535249,-0.03343068,0.01765095,0.00090947846,-0.000996336,-0.030226802,0.017181726,0.038167164,-0.111990705,5.9680124e-34,0.0019593507,-0.02122688,0.03291482,0.02154632,0.014174574,-0.0068707773,-0.02383447,-0.020039413,0.022343203,-0.06618596,-0.09044863,-0.022548435,-0.018455418,-0.011520142,-0.05691306,0.017304169,-0.028862877,-0.046888333,0.06841712,-0.004502233,-0.012306525,0.051647987,0.01631407,-0.045043897,0.107739076,0.015435761,0.04539752,-0.0053845313,-0.0022996743,-0.03251938,-0.07851516,-0.044227105,-0.11491418,-0.0019643763,0.015795402,-0.015033927,0.08925456,-0.054860424,-0.02381905,0.01162681,0.005396448,-0.011289582,0.016084597,-0.06252177,0.062045507,-0.04922084,-0.104079716,0.026979588,0.026441392,0.045978885,0.0296942,-0.036173657,0.057764325,0.039308015,-0.108036555,0.012545089,0.010188948,-0.025491312,0.057851896,0.041256525,0.09423453,-0.030081997,-0.033876732,0.015638795,0.015048291,-0.0016847665,-0.04614218,-0.025793385,-0.032543655,0.08899198,-0.09972631,0.021147545,0.07443504,0.008548928,0.07510828,-0.13839684,-0.070135295,0.11433811,0.020787429,0.10498309,0.0012685044,-0.023148537,0.008491825,0.05660121,0.01282479,-0.032544233,-0.009727071,-0.005141077,-0.09921988,0.002009335,0.012957458,-0.107173204,0.030221628,0.11067317,-0.038985875,-2.2156399e-33,0.026957406,-0.01547655,0.08336785,-0.02782109,-0.024914067,0.02648375,0.013426759,-0.03156904,-0.004850072,-0.0775934,-0.023213645,0.004753931,0.050960474,-0.05206532,0.030282538,0.033775993,0.02680188,0.09884071,-0.045197736,-0.05637118,-0.059240915,-0.016337883,0.035156734,0.041232537,0.058103416,-0.0710398,0.008309538,0.05336765,0.019133756,0.005506694,-0.07774716,0.04135824,-0.057477076,-0.02815803,-0.08640094,-0.0358908,-0.08543828,-0.0023498775,-0.014200154,0.008988314,0.0022574253,0.01492967,0.016079675,0.1638848,-0.01082985,0.08637891,-0.0563414,0.018032908,-0.08112641,0.0033391651,0.008213533,-0.043588117,-0.006110516,0.013395252,0.08265058,-0.017546402,0.011586888,0.048519265,0.014602477,0.06377783,0.013358796,0.011554745,-0.07257436,0.015820226,0.049618777,0.05707171,-0.12783486,0.0075934934,0.09832484,0.016663613,0.109260835,-0.011583223,-0.016488321,-0.0032501498,-0.0049746227,0.077314004,-0.059656803,-0.04870157,0.036807224,-0.028876008,-0.027630007,-0.042336576,0.043545622,-0.0045596673,-0.03211109,-0.060957268,-0.0046191453,0.060590014,0.044378173,0.03370377,0.006395074,-0.019620508,0.045340843,0.06308486,0.03243827,-2.8715633e-08,0.006652425,-0.04712336,-0.037310176,-0.088594444,-0.08047452,0.016590264,-0.016059514,0.02250446,0.03723591,-0.06198092,0.0107687935,-0.042335782,0.019915562,0.079293124,-0.0039269044,0.13343395,-0.0010149828,0.07051598,-0.0017983792,0.033081286,-0.09493241,0.03048709,-0.0628239,0.0553626,-0.010785983,-0.056889605,0.010067791,0.054334987,-0.008598521,-0.034038104,-0.014878929,-0.039742667,-0.06791724,-0.030067204,0.058266994,0.03152837,-0.03199557,-0.07984796,0.010930886,-0.039648697,0.039562356,-0.043439906,-0.06409383,-0.037235267,0.016796306,0.0010185069,-0.0131247975,0.027654149,-0.027627202,-0.06881775,0.032423448,-0.014020948,-0.04677055,-0.12694825,-0.12722173,0.003842172,0.027138093,-0.081529915,0.026638895,-0.10048764,0.055255868,0.009020552,0.13981073,0.015273621 +3.4.21.62,"Subtilisin is a serine endopeptidase, type example of peptidase family S8. It contains no cysteine residues (although these are found in homologous enzymes). Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase B, subtilopeptidase C, Nagarse, Nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo). Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species [1,3]",384,1.0,-0.06979839,-0.07126816,-0.075119786,-0.06950533,0.06131662,0.03620102,-0.076276794,0.09469016,0.03389054,-0.053664036,0.002144112,-0.04336439,-0.01549897,0.122339144,-0.08416565,-0.0034222081,-0.0753312,-0.024143055,-0.010422444,-0.065742806,0.12417195,0.05810072,-0.016346538,0.048056945,-0.052578025,-0.030701362,0.013709516,-0.07331699,-0.01003242,0.032082397,-0.03694796,-0.04801849,0.053224985,-0.06337022,0.13003106,0.009887523,0.027726352,0.021228027,0.14999168,-0.008932017,0.020898033,0.020999758,0.009228198,-0.03433281,0.022480985,0.0146033075,0.0054995758,-0.0124971615,0.021959603,-0.0057757525,-0.02063703,-0.062185235,-0.016511155,0.02653791,0.09437353,-0.07034807,-0.04877603,-0.04244151,0.054442994,0.022539385,0.0019463672,-0.04293569,0.040617354,-0.099669635,-0.0068970197,-0.0014485897,-0.016874917,-0.047938455,0.0019420594,-0.022669347,-0.033479508,0.006779619,-0.11309766,0.15351996,-0.031017713,0.092385285,-0.026063027,-0.016723275,-0.08359677,-0.072114445,0.028683992,-0.0038511315,0.048093833,0.114518024,0.056189995,-0.056091733,0.08057517,0.032363318,0.03941371,0.028535971,0.029667754,-0.043595515,0.00015391644,-0.052234482,-0.008078846,-0.051102236,-0.056689035,-0.016303042,0.049977407,-0.03774701,0.00042136628,0.009571924,0.03791924,-0.043452475,-0.0194885,0.03129159,0.015597083,0.064936444,0.08546655,-0.025967829,0.014699702,0.042047057,0.026176086,-0.104383774,0.036722723,0.010588268,0.044635378,0.035429418,-0.049408328,0.045733076,0.013130675,0.053845678,0.088395424,0.083440915,0.0063289152,0.05749615,-0.14419922,7.976887e-33,-0.014405051,-0.017479759,0.04758432,0.05322876,-0.008111814,-0.03257044,-0.07721983,0.03940869,0.0061255465,-0.04733748,-0.11013845,-0.07503827,-0.032611825,0.01713979,-0.008910662,0.0009435482,0.053690173,-0.04917229,-0.031478435,-0.017774783,0.0037523839,0.05542313,0.04857986,-0.020372383,0.100373365,0.0047083953,0.04997572,-0.016576355,0.045276478,-0.046055403,0.038390186,-0.054083757,-0.08789784,-0.010021058,0.01610073,0.011464627,0.036347006,-0.028975843,-0.021724358,0.04203592,0.0046386397,0.030715128,-0.011437305,-0.03848903,0.076961756,-0.0627777,-0.056148283,0.05221113,0.020467756,0.0074304435,-0.0017109141,0.009077906,0.05361363,-0.041846965,-0.03751028,-0.01223553,0.066643044,0.045139853,0.09213621,0.0337552,0.046454478,0.01923702,-0.0629835,-0.008630606,-0.02445604,0.027172253,-0.06347334,-0.012900268,-0.018465785,0.06711529,-0.039962403,0.055371813,-0.003288381,0.061100326,0.004793838,-0.056937404,-0.075651325,0.04281261,0.050283134,0.041655757,-0.012768978,0.023981672,0.014155628,-0.007754922,-0.08265338,-0.0021047571,-0.0076471125,-0.016322257,-0.055565856,0.029461188,-0.012859755,-0.09335238,-0.028133878,0.06395307,-0.04278688,-7.5037344e-33,0.06867035,-0.055463035,-0.015892237,-0.118558116,-0.107352555,0.0398578,0.0028558648,0.035705492,-0.016466152,-0.008763587,0.0260619,-0.032936398,0.062096953,-0.016154485,-0.020977525,0.041260324,-0.0071555865,0.03626929,0.04624386,-0.0487114,-0.092527464,0.0803079,0.06603392,-0.034620333,0.09406806,0.04740607,-0.042384658,0.18080948,-0.011208201,-0.035711635,-0.043908525,0.014715223,-0.017554617,-0.070517816,-0.08580311,0.03132253,-0.049465816,-0.04063433,0.07695062,-0.04215015,-0.022606904,0.045672104,0.08836338,0.10063217,0.041394528,0.036277056,0.009238947,0.007129743,0.007638097,-0.032070376,-0.05776487,-0.08484759,-0.003832575,-0.049183108,0.023467235,-0.05095067,-0.037145242,0.09135142,-0.011545564,-0.028397772,0.03173115,0.004899498,0.014434713,0.0425996,0.01843365,0.06310218,-0.07519342,-0.03398415,0.06482772,-0.053044464,0.045682047,-0.05827343,0.027213238,0.0040919404,0.029961966,0.009244749,-0.0663857,0.030845867,0.034911178,-0.078424804,-0.061707135,-0.05039911,-0.0067939404,0.019074,0.014380207,0.0045103366,0.03575332,0.04019425,0.026761476,-0.0017755817,-0.030902399,-0.0017753989,0.06349125,0.03572015,0.029894149,-4.286395e-08,0.10508893,-0.07685716,0.027063616,-0.06266655,0.0016457384,-0.048152823,-0.030615289,-0.004613437,-0.002848133,-0.059038635,-0.05727175,-0.047331512,-0.044767454,0.028784145,-0.0018311916,0.027120292,-0.03564052,0.03397431,0.01854003,0.02621056,-0.08405948,0.032247733,-0.070475936,0.054239962,-0.010265629,-0.084436014,0.0007239297,-0.002471369,-0.04840005,-0.06934601,0.02384764,0.06954057,-0.022456424,-0.031673122,0.020131469,0.057743564,-0.09033611,0.039736845,0.025392694,-0.01811284,0.055334613,-0.07284816,-0.06525658,-0.040328395,0.04358656,0.010711009,-0.0012892144,0.023144964,-0.016806018,-0.02203581,0.067179106,-0.04621837,0.028716324,-0.016035588,-0.08425919,0.015886143,0.024340507,-0.05283983,0.06511455,-0.0363979,-0.0031347268,-0.029450616,0.132057,0.0048048636 +3.4.21.63,"A peptidase of family S8 (subtilisin family), not containing cysteine, that is the predominant extracellular alkaline endopeptidase of the mold Aspergillus oryzae. Identical or closely related enzymes are produced by A. flavus and A. sojae [2,3,4]",384,1.0,-0.034173388,-0.014041822,-0.10212091,-0.011645174,0.068869,0.07202255,-0.09524997,0.099878006,0.0064738085,-0.030229192,0.05890127,-0.05749888,-0.04506482,0.06898433,-0.10155595,-0.014245564,-0.011534822,-0.018304808,-0.06676219,-0.087483935,0.10897362,0.064173765,0.022652492,0.06498553,-0.00088227756,0.0060609253,0.0063353055,-0.069836006,-0.01943098,-0.07393361,-0.031918816,-0.03991141,0.07850381,-0.06453614,0.083525494,0.029838517,0.024513656,0.03709647,0.08876157,0.019161666,0.012217102,-0.016523335,-0.011504818,-0.050517205,0.00934496,0.010289044,-0.003642324,0.021764826,0.027779466,-0.0008517278,-0.025382083,-0.07539237,-0.027111389,-0.015725605,0.058394734,0.05107653,-0.026637644,-0.05474608,-0.003911923,0.02185708,0.038950454,-0.040247183,-0.008337326,0.0045598573,-0.022733316,-0.028049834,-0.0020614117,-0.031882755,-0.056184143,0.004609488,0.010934113,-0.03108191,-0.104633436,0.116684236,0.042670235,0.089870244,-0.019282522,-0.04125704,-0.043056622,-0.036101263,0.072519936,0.017270563,0.052131504,0.055208586,0.02368126,-0.047763795,0.032070596,0.07312235,0.027562814,-0.006163351,0.0056007467,-0.027510518,0.043318518,-0.018303562,-0.01792832,0.028759342,0.05033947,0.0064770714,0.02561321,-0.03354244,0.015443199,-0.074550785,0.00525745,-0.03896924,0.0487368,0.030089226,-0.034540296,0.01803468,0.12485372,-0.011390333,0.009405294,-0.05067873,0.004262213,-0.1128685,0.057442743,-0.004609338,0.0649004,0.06235399,-0.0062183784,0.038016148,0.025871823,0.05917824,0.015957948,0.05767576,0.033710744,0.03614343,-0.12752038,2.2326532e-33,0.022632794,0.01649886,-0.023675723,0.020351239,0.034157336,-0.023638112,-0.0178183,0.02029119,-0.0037626824,-0.04430861,-0.11680233,-0.022051368,-0.07368447,0.019188631,-0.009753337,0.029116947,-0.023487655,-0.03256922,-0.03243632,-0.008384817,0.011559416,0.0683312,-0.06425799,0.011299853,0.091141425,0.022063209,0.07800652,-0.07189946,0.003251139,-0.04611646,0.014214117,-0.038984384,-0.09225686,-0.007995601,0.057519503,-0.014219393,0.086556934,-0.072330005,-0.04545395,-0.020666545,-0.011469653,0.014119455,-0.04108593,-0.06364865,0.06803198,-0.07285886,-0.08383472,0.04737288,0.045021746,0.041128725,0.060009703,0.0029370268,0.071149565,0.080895685,-0.08011478,-0.005042073,-0.019528272,0.059784018,0.10116224,0.05072348,0.04431171,0.043393824,-0.031351477,0.016351642,-0.039695654,-0.027319055,-0.05429247,-0.009377921,0.024551613,0.03951368,-0.024867557,-0.0051004174,-0.0071249777,0.0386927,-0.012845079,-0.06826173,-0.0905901,0.047322217,0.045957506,0.01587776,0.0065802326,0.036151595,-0.0017088443,-0.049824577,-0.08358807,0.00086605625,0.0054968502,-0.0011881904,-0.094838895,0.04585938,-0.040188722,-0.08019417,0.0052560796,0.07645966,-0.014851641,-2.9010104e-33,0.083814636,-0.09582851,0.01108396,-0.036401078,-0.066414766,0.055158507,0.03575792,0.017188417,-0.0126983095,-0.012030474,0.025080755,-0.027273837,0.08173706,-0.015594621,0.007397781,-2.7086315e-05,0.009098952,0.086094856,0.047746927,-0.067585036,-0.09206692,0.058950216,0.032363348,0.05093992,0.089387834,0.022473829,-0.05910771,0.10509071,-0.0561,0.037404507,-0.029178955,0.020394443,-0.005632967,-0.034561634,-0.06544469,0.07368795,-0.045486778,-0.0013627702,0.028639223,0.0052964534,-0.024005264,-0.013284605,0.05731165,0.16005465,0.031854223,0.050175473,-0.034724265,0.04596667,0.036019687,-0.06690062,-0.012638273,-0.044839717,-0.035385083,-0.0050916728,-0.009632767,-0.02381176,0.024364635,-0.002721426,-0.010065408,-0.016266562,0.018387295,-0.009796995,0.00017070107,0.008090731,0.057611622,0.07128419,-0.10364073,-0.0675987,0.0848538,-0.019973548,0.07112486,-0.064510904,-0.0137231825,0.066942744,0.02262106,0.020510273,-0.03879542,0.0109117795,0.03772873,-0.03584186,-0.08949564,-0.05523323,0.029661845,0.03357957,-0.009882475,-0.12181357,0.091729484,0.057294793,-0.011245548,0.04907459,-0.008614896,0.030264815,0.014957983,0.04968172,0.055512834,-3.514508e-08,0.11829115,-0.035962656,0.044726532,-0.09164258,-0.024404801,-0.07676398,0.0640832,-0.009911445,0.033371255,-0.06179894,-0.020534601,0.00064625376,-0.045827754,0.08700006,0.05882427,0.01803763,-0.0040028812,0.08945237,0.005888398,-0.006248341,-0.06656419,-0.0014133459,-0.098643616,-0.013552963,-0.07199805,-0.02760801,0.012178142,0.041310947,0.028656261,-0.011341728,0.03185966,0.031980548,-0.044806585,-0.027553126,-0.032708995,0.053087138,-0.047739495,-0.015210288,0.0038734735,-0.031232629,-0.051891517,-0.0968543,-0.023623958,-0.053989224,-0.034229986,-0.06641464,0.049083184,0.012404368,0.0035045634,-0.010933658,0.044270545,-0.06846474,-0.007165555,-0.065396704,-0.10625734,-0.0398116,0.04585269,-0.03376183,-0.007882028,-0.06566568,-0.01610161,-0.012346974,0.19795848,0.007619938 +3.4.21.64,From the mold Tritirachium album Limber. A peptidase of family S8 (subtilisin family) containing two disulfide bridges and one free Cys near the active site His. Formerly included in EC 3.4.21.14,384,1.0,-0.076729216,-0.012433514,-0.06801227,-0.050350722,0.01379104,0.02649401,-0.017005946,0.12426438,0.03346594,0.0141427405,0.09517724,-0.08270832,0.012281578,0.021398973,-0.076477826,-0.018037923,-0.043712907,0.00985528,-0.013907209,-0.050311096,0.008627834,0.06427332,0.0077351807,0.08427584,-0.065289006,0.03430997,0.011358949,-0.0128862355,0.04817752,-0.081165515,-0.031678934,0.038179673,-0.02878177,-0.02453615,0.11339915,0.033031255,0.014856588,-0.038744453,0.11261119,0.05895264,0.05109399,-0.007935682,0.017915078,-0.037175767,0.060484815,0.06819275,-0.035529286,0.078439586,0.023668254,0.00464327,0.021753673,-0.033623174,0.0367757,0.08551445,0.021960996,0.01266152,-0.012325822,-0.03020733,-0.0021446843,0.04198148,0.1008419,-0.007248014,0.005208149,-0.0034981447,-0.07612568,0.008961252,-0.03022471,-0.010576531,-0.00035222204,0.016850216,0.01731332,-0.004874413,-0.028028354,0.08460772,0.031590212,0.007380845,0.042290803,-0.047709778,-0.05356481,-0.085929304,-0.023262925,0.02943186,0.04869654,0.046276804,0.0101306625,-0.019261647,0.017249178,0.0023908298,0.005996386,-0.041396517,-0.0012560149,-0.037853885,0.08878989,-0.017750485,-0.06836436,0.020527849,-0.032369014,0.04633845,-0.0025215216,0.0004872638,0.06589046,-0.019031657,-0.037837673,0.011330869,-0.05235967,0.00591904,-0.02940852,0.05232952,0.1298445,0.017420093,-0.08331694,-0.027818352,0.029127032,-0.08914982,-0.0721661,-0.032064293,0.074733995,0.021638632,0.09366418,-0.0055540847,0.056027792,0.021380354,0.00017323637,0.009666437,-0.022262182,-0.041079327,-0.15227628,3.947578e-33,0.03596893,-0.010210823,0.0080579845,0.07452489,-0.0032408128,-0.020310001,-0.08880442,-0.04751352,-0.0653848,-0.05823361,-0.1556765,-0.029114347,-0.057985626,-0.0006328908,-0.062592745,0.019229617,-0.041694853,-0.0045509106,0.0035227495,-0.033240773,-0.029855527,0.10485901,-0.028316164,-0.03384619,0.09680219,0.031477284,0.059217665,-0.07335364,0.055233065,-0.009860922,-0.05025,-0.0014736435,-0.039970595,-0.001123551,-0.015870381,-0.02233366,0.067522205,-0.08155973,-0.09470252,0.024589095,0.016429912,0.006003448,0.048345827,-0.07437417,0.10716022,-0.060748786,-0.05120584,0.028628709,0.0032338558,-0.0017723145,0.029383203,0.043730352,0.054740775,0.046554472,-0.10756792,-0.009238941,-0.055922147,0.01667668,0.120663956,0.069476075,0.048572004,0.086652674,-0.031892024,-0.0025044703,-0.0074442415,0.031039426,-0.059608907,-0.013495641,0.017813465,0.061933666,-0.08359232,-0.008727114,0.017422194,0.105619736,0.05896677,-0.078475885,-0.046049498,0.009362243,0.04373252,0.045485217,-0.036652062,0.011191833,0.057471357,0.03107723,-0.022547465,-0.0689652,0.021055896,-0.05497868,-0.0529237,-0.01730932,-0.009383622,-0.051486246,-0.04659201,0.028966563,-0.05719732,-3.4451848e-33,0.039161038,-0.030502005,0.0018491523,-0.065381445,-0.03445683,0.007991853,-0.032805987,0.061765376,0.036387324,-0.006951274,0.098675154,-0.01273831,0.0178786,-0.028291518,0.03236585,0.015823472,0.07956312,0.009650636,-0.02791968,-0.025485879,-0.02170832,0.030673988,0.015078691,-0.022107271,-0.014139912,0.01096459,0.026170067,0.10404006,-0.013383661,0.009993624,-0.04414302,-0.061563753,-0.06491833,-0.060350817,-0.055528294,-0.02038341,-0.047335193,-0.028099278,-0.0051469556,-0.102593064,0.02135304,-0.009364166,0.03123853,0.12765324,0.053581636,0.037710987,-0.05526291,0.049930617,0.0029687833,0.0066503547,-0.0021895631,-0.07033745,0.014761212,0.015637742,0.07820443,-0.11086367,-0.07840051,0.015454831,0.0052821753,0.08192554,0.068414725,-0.0031025654,-0.05459903,0.02175403,0.048976656,0.08301948,-0.12989789,-0.031103661,0.04256473,0.043175343,0.06883813,0.021199554,-0.011688512,0.013724078,0.04896616,0.04593851,-0.043452777,-0.013286187,0.04384173,-0.06426028,-0.044330947,-0.100431986,0.009780008,0.06464915,0.07005055,-0.062355295,0.054188784,0.06874591,0.055788375,-0.01966318,0.0024159534,-0.0042538615,0.013151556,0.08377432,0.03928067,-3.591738e-08,0.10694095,-0.0020524263,-0.009707261,-0.11860239,-0.026905306,-0.00828613,0.04597623,-0.015457384,-0.019648943,-0.019426415,0.048165016,0.0032725993,-0.039189592,0.036753345,0.0429176,0.05415144,0.014672454,0.08869332,-0.0046099573,-0.0030889553,-0.009317412,0.04012744,0.014823324,-0.022879042,-0.032153256,-0.042535927,0.042974494,-0.07718072,-0.027015302,-0.049185913,0.039561152,0.05112751,-0.063846834,-0.0005495399,-0.008882354,0.048838045,-0.12185776,0.06190135,0.0046167653,-0.039624803,0.009184337,0.0063431393,-0.057121217,-0.0036464252,0.0317928,-0.05621565,-0.014045256,0.028646955,-0.014857924,-0.06892441,0.02253234,0.023789363,0.04226477,-0.031086778,-0.11301245,-0.07434878,0.016707424,-0.050589092,-0.0026346124,-0.06966682,0.023284877,-0.058661,0.10130873,0.10035055 +3.4.21.65,"A peptidase of family S8 (subtilisin family) from the thermophilic fungus Malbranchea pulchella var. sulfurea containing Cys, but not inhibited by p-mercuribenzoate. Very thermostable. Formerly included in EC 3.4.21.14",384,1.0,-0.03332175,-0.028566163,-0.12967525,-0.016369723,0.03425259,0.07899672,-0.017215567,0.053891376,0.019524809,-0.025889633,0.066569105,-0.05463857,-0.013549127,0.04009005,-0.088714555,-0.0015069791,0.0039385236,0.0028087688,0.026087217,-0.08523092,0.06572107,0.07245003,0.0034645738,0.09423698,-0.06218617,0.049225684,-0.0135312425,0.0014642627,-0.06426552,-0.022528222,-0.06462073,-0.016368432,0.13127908,-0.039776172,0.080772564,0.06576034,-0.036517736,0.0051762746,0.05020563,0.00078500295,0.0114945965,-0.032155532,0.013495601,-0.011068271,-0.054927703,-0.03139451,0.033427473,0.044324055,0.038121764,-0.106336065,-0.005274142,-0.06100774,0.016292093,0.02437565,0.0029809396,0.02395856,-0.034399416,-0.04844431,-0.009104859,-0.052225623,0.016249886,0.059449546,0.005120712,-6.2162544e-05,-0.05494145,-0.006937309,0.029517125,-0.024973994,-0.008780743,0.049755335,-0.06459353,-0.017333139,-0.07922659,0.0904786,0.032727,0.06933,0.058737222,-0.110210784,0.0049738404,-0.081326135,0.0054880013,-0.05535288,0.047233447,0.079067715,-0.0033623083,-0.07044803,0.10910569,0.0061200066,0.076192655,-0.02313986,0.04171099,-0.028267393,0.06384347,0.015173389,-0.0746196,0.03791056,-0.017826619,0.009804276,0.050096445,-0.038477313,0.029062627,-0.024091462,-0.06763828,-0.025391333,-0.012968962,0.03375221,-0.015678816,0.0432258,0.08241056,-0.024199842,-0.06827843,-0.010194196,-0.012559047,-0.086383216,0.01320092,0.006731561,0.099998266,0.032161765,-0.0011044391,0.016970439,-0.018571077,0.08542634,0.008437733,-0.00020400011,-0.011815978,0.028212104,-0.15023097,3.0502407e-33,0.033693273,-0.0166067,0.024403261,0.0042534433,0.015233021,-0.044067338,-0.08768219,-0.03968637,0.00020703676,-0.0060039703,-0.11460489,-0.03537869,-0.07604948,-0.028761838,-0.00087906135,0.028418936,3.3613174e-05,-0.018531745,0.048417095,0.0035988379,-0.030913725,0.10074173,0.00061989174,-0.06768564,0.065714575,0.060530778,0.09898942,-0.003995399,0.042411193,-0.020584008,-0.022316016,-0.02756726,-0.116647474,-0.027075863,0.030194543,-0.022707481,0.00057214755,-0.021843538,-0.02948122,0.024267584,0.01531402,0.03780847,0.030333418,-0.07301701,0.06526726,-0.05118373,-0.0963594,0.06826438,0.034579404,0.032264743,0.017656527,-0.026628401,0.07513079,0.02849461,-0.05520439,0.004989074,0.05172443,0.08321246,0.079072446,-0.015586789,0.041224387,0.03940554,-0.029119484,-0.024167266,0.033485763,0.031288907,-0.024981739,-0.028272187,-0.039513323,0.027059918,-0.12353638,0.029314423,-0.028771602,0.05198732,0.038756184,-0.1120905,-0.063268684,0.027224204,0.015162507,0.038626295,-0.0450402,-0.0411934,0.048532967,0.0046289377,-0.06282032,-0.028950514,-0.027583959,0.09723777,-0.054845598,0.016526397,-0.010694719,-0.08811923,0.045505077,0.08995022,-0.038150903,-3.804049e-33,0.056925736,-0.055825125,0.06673432,-0.026945498,-0.03896659,0.057545293,-0.013723657,0.020599717,-0.052174848,-0.01759753,0.038221423,0.004787201,0.05471089,-0.080629505,0.01730877,0.07062413,0.03198837,0.033074517,-0.04474773,-0.06436486,-0.12737836,0.08912183,-0.00415127,0.022650855,-0.023321763,-0.060546592,0.022968665,0.11680255,-0.016113259,-0.037362754,-0.022713926,0.021052498,-0.06484552,-0.062265724,-0.09771245,-0.0211258,-0.061725467,-0.0020183914,0.043883886,-0.017149951,0.027037723,0.026261155,0.0291652,0.14708562,0.03676165,0.06838244,-0.05588981,-0.011988397,0.015237935,0.03718233,-0.016827509,-0.08382685,0.030129457,-1.5269943e-05,0.077937625,-0.042869985,-0.057155773,0.00054622383,0.033487875,0.0087122945,-0.0053991033,-0.015454508,-0.012539607,0.05393777,0.01206702,0.12608117,-0.15008152,-0.022401618,0.11873921,0.004171108,0.09188082,-0.039269038,-0.029286945,-0.0038645105,0.029038168,0.02626558,-0.050415937,0.0453169,0.045552813,-0.024358436,-0.012469228,-0.02253116,0.009445201,-0.019258136,0.044626202,-0.10329766,0.04870409,0.047865596,0.022933384,0.018291224,0.0347881,-0.0066527426,0.061231375,0.03034186,0.0075335405,-3.2871217e-08,0.10753589,-0.04946501,0.038848132,-0.04442275,-0.026104765,0.0039317245,-0.0076365834,0.0038610534,0.04662102,-0.0031474717,-0.0016656369,0.03214349,0.067595445,0.099855445,-0.023169132,0.05361476,0.011299911,0.058807768,-0.00040837735,-0.007572781,-0.088236965,0.008946064,-0.06490929,0.039438356,0.036507826,-0.04192407,0.03601827,-0.032399885,-0.01916601,-0.032320887,0.014663987,0.056604184,-0.06082629,-0.026112545,0.011175476,0.06050824,-0.056168366,-0.034174457,0.016801251,0.010885258,0.08888193,-0.04023364,-0.051980287,-0.013779166,-0.02255295,-0.041948352,-0.025957692,0.059512038,-0.024732519,-0.0023895798,0.0559844,0.025650412,-0.041347302,-0.06620335,-0.0902641,-0.021406243,0.08212645,-0.05233484,0.008736171,-0.051132597,0.011916567,-0.10597428,0.047852345,0.02031481 +3.4.21.66,"A peptidase of family S8 (subtilisin family) from Thermoactinomyces vulgaris containing a single Cys, near the active site His, and inhibited by p-mercuribenzoate. The N-terminal extension of the polypeptide chain relative to subtilisin contributes to Ca2+-binding and the high thermostability. The amino acid composition and properties of the thermostable enzyme from Streptomyces rectus var. proteolyticus (formerly included in EC 3.4.21.14) are closely similar [1,2].",384,0.99999994,-0.037202056,-0.065924026,-0.15359846,-0.058557834,0.022727914,0.084354036,-0.033299413,0.10641062,0.047195673,0.0008642558,-0.005629036,-0.048850086,0.0716903,0.08243062,-0.06453384,-0.05469995,-0.0031739958,-0.019878903,0.063651405,-0.13052215,0.10073218,0.069577076,-0.0033154697,0.012265839,-0.007486476,-0.017375618,-0.006205096,0.018976975,-0.08483779,0.025232982,0.008231941,-0.040437028,0.06733279,-0.034159437,0.08970338,0.119020924,-0.014834238,-0.040424895,0.06262118,0.044340685,0.023332667,0.022485884,0.010796658,0.014778036,-0.002584426,0.008955171,0.0670634,0.03191904,0.04255426,-0.055167165,0.009616535,-0.07850254,-0.0154765565,0.06406565,0.022017894,0.05347005,0.025698684,-0.027958618,-0.030074056,-0.07091492,0.027722955,-0.025245037,0.01704066,-0.010364262,-0.062274773,-0.035513073,-0.016142908,-0.014755018,-0.023162039,0.007858767,-0.09736984,0.00860702,-0.0418547,0.052229702,0.034923334,0.039403517,0.030386683,-0.06251282,-0.059739243,-0.099004656,0.04064657,-0.041508295,0.05088896,0.07824815,0.026064957,-0.051807657,0.14822508,-0.05672811,0.087490715,0.003299634,0.06682159,-0.038730834,0.06836501,-0.028846243,-0.038004108,-0.025144402,-0.08658946,-0.046956815,0.05763793,-0.05040701,-0.010061852,-0.0046702325,0.019908536,-0.016035443,0.009368771,0.06530563,-0.038283728,0.061320666,0.07875088,-0.051655922,-0.003768255,0.020660212,0.027082818,-0.027848516,0.060775094,0.045722526,0.057844024,0.013805579,-0.019060258,-0.028882561,-0.03291513,0.056205623,0.061478943,0.01975368,-0.027808418,0.02950153,-0.11925269,2.4484543e-33,0.0027896645,-0.011794308,0.054984458,-0.009618434,0.0670324,-0.012407344,-0.102942355,-0.044531498,0.052326083,-0.021142015,-0.07381741,-0.03665144,-0.019750586,-0.013358373,-0.0075825443,0.030902576,0.033180285,0.022231309,-0.005056454,0.024749598,-0.02676244,0.058568027,0.030138731,-0.06778245,0.09669381,0.054110527,0.04781968,0.03504145,0.037583504,-0.05633924,-0.01549929,-0.0496292,-0.15802419,0.04579128,0.018319402,-0.050393198,0.019756809,-0.055295445,0.04062656,0.030231223,-0.010545289,0.02466802,0.057462,-0.008787354,0.084096074,-0.05964746,-0.094985165,0.06575195,0.0073327706,0.05369736,0.012393964,-0.008541818,0.10377442,-0.011867145,-0.08854066,-0.025090978,0.027958384,0.09858215,0.074890606,-0.015236968,0.037898514,-0.011809107,-0.025627537,-0.0049534147,0.02501059,0.028171055,-0.02962588,-0.013999914,0.005818415,0.075333014,-0.09489438,0.060767237,0.011528354,0.0060888776,0.045407306,-0.08505093,-0.073011376,-0.009178743,0.024892442,0.022523575,-0.0462029,0.011653892,-0.013175518,0.004046431,-0.06411185,-0.005847559,-0.004753167,-0.006541167,0.00482613,0.06361489,-0.0037527364,-0.06376162,0.008536218,0.10759553,-0.00016868049,-2.02922e-33,0.095318735,-0.06304059,0.028020136,-0.013478833,-0.064951085,-0.00284623,-0.0009839633,0.04782563,-0.05134047,-0.058051668,0.029795066,-0.042039223,-0.014122612,-0.062605776,0.027408713,0.059627075,-0.020048017,0.08728493,-0.04272044,-0.040293325,-0.06382812,0.07175624,0.051004726,-0.028481344,0.01048187,-0.020933405,-0.018851867,0.117652945,0.0058576954,0.0012545357,-0.033641577,0.018346783,-0.09100671,-0.06310484,-0.09495598,-0.013965305,-0.06064887,-0.0058762697,0.11535093,0.0025337397,0.06169723,0.06518958,0.019147694,0.095087,0.033788264,0.08408103,-0.026475,0.011465667,0.0112235,0.004255969,-0.02661047,-0.11525259,0.0025969776,-0.019241156,0.028622195,-0.040759865,-0.040318865,0.037635457,-0.0071549304,0.010557683,0.0066047846,-0.042665254,0.02299181,0.054039363,0.009607506,0.078222334,-0.06995917,0.015790578,0.17170121,0.016085602,0.08781698,-0.046823278,0.007001903,-0.00934183,0.018993948,0.01974004,-0.07469226,0.006827318,0.033711772,-0.025599428,-0.05069484,0.0014508076,-0.015399857,-0.07487989,0.034291364,-0.057220127,0.054890074,0.029908193,0.005974102,0.021794008,0.025950227,-0.044961806,0.07285377,0.06081936,0.035393607,-3.8734523e-08,0.08260259,-0.023426406,0.065495804,-0.0299041,0.037319608,-0.038826358,-0.03835615,-0.050753325,0.05974453,-0.025716467,-0.04176764,-0.027321259,0.014926371,0.04081185,-0.046743393,0.09323133,-0.030902416,0.015241728,0.011896242,0.007580833,-0.059180558,-0.032285884,-0.11126122,0.067994066,0.04992354,-0.03169066,-0.023985337,0.0072110035,-0.03691489,-0.020307746,0.0059666974,0.022785379,-0.04146638,-0.025536966,0.01545569,0.018820008,-0.03673146,0.0034299868,0.02657265,-0.047894143,0.086758114,-0.07702018,-0.0046603805,0.0046775695,-0.069235094,-0.010600711,-0.00841537,0.020352595,-0.026440995,-0.003946919,0.0642162,-0.00650145,0.0018785904,-0.044840593,-0.11838057,0.009254686,0.028478349,-0.037592154,-0.025442947,-0.026109623,-0.03360878,-0.05960708,0.08887589,-0.07711797 +3.4.21.67,"An Escherichia coli cytoplasmic endopeptidase formerly included in EC 3.4.21.14. Inhibited by Tos-Phe-CH2Cl, but not by Tos-Lys-CH2Cl",384,1.0,-0.05313431,-0.030684678,-0.038802106,0.019981513,0.09810372,0.103920974,-0.04270907,0.096613206,0.07911698,0.048869204,0.034039702,-0.046996634,-0.053171862,0.1284221,-0.046259284,-0.028654838,-0.05957568,-0.009478361,0.016928239,-0.044326216,0.04172164,0.044202883,0.00063012145,0.032519557,-0.025237305,-0.024947498,-0.056354363,-0.07499514,-0.07073304,-0.04375333,-0.0014676953,-0.0423015,0.022267262,-0.060887877,0.08861699,0.029593077,0.04639409,-0.083995454,0.04306863,-0.029298607,-0.00029310078,0.052123364,-0.03908221,0.037057027,0.03801378,0.057107214,0.019250209,0.011020414,-0.011401173,0.009293503,0.024433384,-0.04017624,0.016396781,-0.03685483,0.008832914,0.07762603,-0.027668927,-0.0077548726,0.013961263,0.017303249,0.06675357,-0.027736207,0.02881266,0.016662022,-0.023651412,-0.08255781,0.03994821,-0.052415967,-0.013785588,-0.002000888,-0.063752614,-0.08112347,-0.048463132,0.11661817,0.044083025,0.068407446,0.032179154,-0.017416576,-0.07396351,-0.060225718,0.06854431,-0.09763244,0.0103649525,0.054299325,0.02850161,7.564688e-05,-0.028224595,0.03420182,0.020069538,0.051273778,0.0038048306,-0.09413725,0.050443448,-0.00817673,0.021356413,-0.034378,-0.006243146,-0.029811777,-0.009216932,-0.04517816,0.005185314,0.0059464066,-0.045091774,-0.058346048,0.031997267,0.0027743843,-0.0013846467,0.017093793,0.025039958,-0.085485965,0.07568661,-0.031794358,0.031758074,-0.09196703,0.03688878,0.022994881,0.044435736,-0.04449869,0.028080447,0.045897424,0.07550577,-0.0863882,-0.006159093,0.053064425,-0.06633648,0.03801546,-0.069427066,1.9850141e-33,-0.022194395,0.025492333,0.015916964,-0.009199141,-0.00844618,-0.004958125,0.04449089,-0.004065724,-0.03976497,-0.023174603,-0.10833772,-0.079954974,0.026768595,-0.015402428,-0.024841333,0.016478062,-0.014858961,0.018890433,-0.039973695,-0.036058627,0.024528148,-0.011560738,0.014166302,-0.016048951,0.095493644,0.03227602,-0.060754333,-0.01655279,0.14206986,-0.0013051354,-0.013531156,-0.035997584,-0.05203981,0.04284133,0.04549201,-0.02215421,0.020292072,-0.07649972,0.0027713182,0.029432056,0.026953967,0.03326579,-0.045630552,-0.014236892,0.06354761,-0.06647143,-0.06792957,0.07374703,0.0064727194,0.05342565,0.017393664,-0.033704776,0.0469113,-0.028048962,-0.03420676,-0.0035019368,-0.011524491,0.028899768,0.017993724,0.03160331,0.022643302,0.10289265,-0.08546032,-0.046612233,-0.020793945,0.008370636,0.0006759426,-0.04097013,-0.06673568,0.014855271,-0.0765908,0.0050225207,0.08837756,0.046256196,0.0534363,-0.03885378,-0.1282275,0.04736335,0.06273849,-0.0028055029,0.103511006,0.0013270058,-0.0005580615,-0.0019043443,0.041543525,-0.019984446,0.010721421,-0.027919455,-0.04214732,0.06005605,0.0676318,-0.036126737,0.02448581,0.08668955,-0.088255614,-3.1540056e-33,-0.012342637,0.008116493,-0.041565135,-0.07142593,-0.05551746,0.04473993,-0.08567733,-0.009387256,0.01333845,-0.052036177,0.1363903,-0.05845276,0.06360731,-0.034504887,0.008224148,-0.04684483,-0.010665696,-0.0041007777,-0.004598584,-0.020694252,0.009404953,-0.090986356,0.05514856,0.037318375,0.07858991,0.025921794,-0.03169769,0.07335043,0.038645662,0.031592727,-0.01801339,-0.013277318,0.004221797,-0.07265742,-0.054107007,0.016891219,-0.109901205,-0.0050842213,0.06376932,-0.024164727,0.023167927,-0.0039464654,0.04654552,0.052552614,0.03254859,0.055158097,-0.026040059,0.05470283,0.06252416,-0.09566966,-0.028984286,-0.08231149,0.012870891,-0.01158216,0.0045985603,-0.013801432,0.000771537,0.061819293,0.018640427,-0.062061004,-0.0014944081,-0.049332835,0.014904383,0.04868546,0.09493453,0.025717996,-0.08616865,0.061574776,0.034685016,-0.049880818,0.0058657774,-0.013333624,0.008520323,0.006979388,-0.030056385,0.0040248306,-0.06732735,-0.06926886,0.10091578,-0.06514515,-0.07475125,0.023579413,0.017816762,-0.046923153,0.1221216,-0.12683389,-0.015560916,0.065367825,-0.016281143,0.021430004,-0.0593011,-0.019064749,0.043047328,0.027655,0.05769843,-3.4104445e-08,0.13715084,-0.05024451,0.010491403,-0.099541746,0.03071519,0.005416251,0.021274816,0.055400055,0.046233274,-0.011884732,0.022835959,0.036617216,0.04012883,-0.0025080764,0.03621863,0.08110826,-0.023119073,0.05650863,0.033380494,-0.0047932826,-0.01850607,-0.008857168,-0.093892924,-0.08525836,0.04776356,-0.012762395,0.01021081,0.060215704,0.006135813,-0.06786901,0.0027053657,-0.08061245,-0.053026926,0.04240358,-0.032871146,0.025278704,-0.110689305,0.012295555,-0.028386597,0.026348855,-0.00623512,0.07248686,-0.085416526,0.067603946,0.022762524,-0.01570604,0.07544128,0.028856855,-0.07996839,-0.08086212,0.026690027,-0.11249465,-0.007499366,-0.040899314,-0.080211855,0.0012670889,0.026834048,-0.05403687,-0.028852444,-0.052950572,-0.029296666,0.022680936,0.13900043,0.07356606 +3.4.21.68,"A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC 3.4.21.31 and EC 3.4.99.26",384,1.0,-0.106006116,-0.057627164,-0.07268311,-0.03105773,0.056108207,0.08425784,-0.020082638,0.11706584,0.046580408,0.06271694,0.04630797,-0.06405064,-0.032250293,0.109886535,-0.03624187,-0.04470053,-0.05988769,-0.05702891,0.056476858,-0.06683838,0.01395367,0.07102771,0.0031567856,0.0333515,-0.08024179,0.029567799,-0.02686092,-0.020846797,0.014661783,-0.0069498704,-0.0255328,-0.0783119,0.014531272,-0.008980238,0.02457664,0.014505502,0.050086543,0.03249339,-0.040904224,0.009629654,0.055947416,-0.029946115,-0.012179694,-0.08083021,0.052921966,-0.017822152,0.031204112,0.082066946,0.06214618,0.042765226,0.0049608154,-0.048825264,-0.0071876063,0.013002511,0.09472856,0.06347986,-0.09627693,-0.04024402,0.011473049,0.007802324,-0.012984385,-0.03049729,0.037184723,0.0010231548,0.012465494,-0.053610276,-0.038757764,0.019743247,-0.016179334,0.037148166,-0.007304793,-0.008371377,-0.0808918,0.10364756,-0.00784717,0.06538982,-0.019024285,-0.017761152,-0.045730285,-0.03329988,0.013000318,-0.030579591,0.038664438,0.10492545,-0.03667769,0.025840744,0.043961536,0.024567224,-0.029320147,-0.05673807,0.018519092,-0.09094877,0.06934067,-0.005325736,-0.013122536,0.05436977,-0.09181139,-0.0060739922,0.011741674,-0.013563336,-0.002639323,-0.0323672,-0.007837474,-0.08370446,-0.006077342,0.0393617,-0.06452969,0.057470936,0.14732133,0.0053844946,-0.007430299,-0.023190856,0.010114297,-0.036906105,0.0068580164,0.02630404,-0.006762916,0.00973451,0.004002233,0.034267664,0.0682046,0.03469645,0.003546677,0.05197339,0.0066936836,0.008933196,-0.045827616,6.952008e-34,0.02205975,-0.07330963,0.03642602,0.08018988,-0.009108205,-0.008970049,-0.030624153,-0.021776026,-0.0338679,-0.03141066,-0.11582719,-0.038922172,-0.035056923,0.01842626,-0.055712067,-0.014146231,-0.10123046,-0.027204718,0.09030584,0.0021491433,-0.012997911,0.11937658,0.056931764,-0.10526972,0.053415056,8.637263e-05,-0.021537589,0.0016342018,0.0845265,-0.02179617,-0.06192807,-0.0314853,-0.044660304,-0.025320832,-0.023697196,0.011333824,0.074868664,-0.090117246,-0.0072479257,0.019192003,0.062643,0.023309872,-0.063339114,-0.053560063,0.067075625,-0.05494306,-0.054686643,0.042527493,0.02207912,0.004192633,0.049037598,-0.032987256,0.09104083,0.020736123,-0.06418767,-0.03300932,-0.055987716,0.006326882,0.023814466,0.024739329,0.050865225,0.030595804,-0.06312519,0.036317647,-0.024620393,0.009824791,0.010598478,0.01617631,0.016252173,0.025809536,-0.046687223,0.072780155,0.015237455,-0.051518537,0.08163038,-0.07402833,-0.0010650345,0.114520416,-0.015757928,0.03699506,-0.049781073,-0.023605987,-0.03574768,0.0636247,-0.059077222,-0.025508543,0.036780443,-0.014265401,-0.040783405,-0.07388433,0.0012310958,-0.03746032,-0.014121876,0.10013981,-0.042412676,-1.579825e-33,-0.02313079,-0.08220351,0.10443854,-0.026528604,0.01639227,0.06690516,0.062451605,0.0056736707,0.030266933,0.024605704,0.039746672,-0.039285142,0.031928122,-0.110603936,0.030560166,-0.025221182,-0.00856703,0.010752345,-0.025467034,-0.068883434,-0.075961284,-0.011122699,0.02597219,0.08708208,0.08694263,0.07531846,-0.09329002,0.048803907,-0.04144199,0.0071923886,-0.016469754,-0.016833292,-0.091000415,-0.042352445,-0.006340386,0.008145688,-0.052910525,0.025333062,0.042428534,-0.09937589,0.057279818,0.07892863,0.06043679,0.09810216,-0.023720702,0.12469526,-0.048238914,0.023622733,-0.032070715,-0.06191383,-0.06819804,-0.031567127,-0.026355973,0.03187737,0.08117587,-0.03394439,0.050634835,0.060425837,0.009705036,0.040511295,-0.032962035,-0.046377435,-0.051789254,0.04447357,0.09484225,0.030335909,-0.060144562,-0.015894385,0.031884674,0.015887272,0.09978577,-0.030715154,0.008785444,0.014665888,0.04384403,0.049554117,-0.029219208,-0.107834846,-0.010005508,0.00014383763,0.00021646837,-0.052326657,-0.043157984,0.0019315751,0.049484234,-0.071430676,0.07091481,0.074437805,0.045539804,0.03128426,-0.02307175,0.015533302,0.0065719117,0.032169998,-0.024581363,-3.9177117e-08,0.0641521,-0.06798402,0.028823191,-0.08529216,-0.08223335,-0.016001211,-0.017347725,0.06158641,0.034554135,-0.03899982,0.03719554,0.008583004,0.029739399,-0.015651045,0.044103883,0.022946049,0.013499707,0.05522472,0.011786502,-0.06259903,-0.07612415,-0.004091104,-0.045209296,-0.0020281777,-0.025476059,-0.06601382,-0.014588684,0.031116428,-0.0040152515,-0.06309897,-0.001612496,-0.017469198,-0.018139238,0.077301756,-0.026060268,0.061474714,-0.012635039,0.035641037,-0.009194412,0.040470652,0.0063351425,-0.032491863,-0.010099135,-0.05282568,-0.07265728,-0.045861747,0.06208118,0.056514245,-0.016041204,-0.040270258,-0.0010649598,0.0018038641,-0.056810208,-0.082935855,-0.112286545,-0.055794545,-0.04732239,-0.030550223,0.042988792,-0.062701665,0.017488468,0.038660932,0.16204946,0.14188723 +3.4.21.69,"A peptidase of family S1 (trypsin family), one of the gamma-carboxyglutamic acid-containing coagulation factors. The enzyme plays an important role in regulating anticoagulation, inflammation, and cell death by proteolytically inactivating the blood coagulation factors factor Va and factor VIIIa. Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin. Protein C can also be activated by serine endopeptidases present in several snake venoms.",384,1.0,-0.039980832,-0.017569857,-0.10929306,0.0017735005,0.07159641,0.14565212,0.019043015,0.104402095,-0.010489996,0.0031422672,0.015778588,-0.08578145,-0.0038882222,0.1325677,-0.06280275,-0.012040344,0.03897188,0.014761342,0.016401395,-0.107111625,-0.031270966,0.033940002,0.04251166,0.034564286,-0.09645441,0.019964725,-0.06376666,-0.051255252,0.015445352,-0.0112841735,-0.05746616,-0.06571734,-0.027062321,-0.07179531,0.05285745,-0.020122731,-0.021367617,0.0024766282,-0.042632002,0.0027149862,0.060769,0.044866834,-0.05682545,-0.008851255,0.018614233,-0.01862458,0.014446632,0.12494179,0.06279909,0.044936314,0.02802035,-0.042355843,-0.035370998,-0.06164726,0.036349256,0.0043122666,-0.06225634,-0.04142139,0.06330536,-0.0039920304,-0.014793365,0.025901882,0.033804093,0.030967623,0.08187832,-0.10919777,0.01614837,0.00052316714,-0.04651248,-0.018628482,-0.024673771,-0.05289371,-0.06492183,0.13091475,-0.0013200435,0.07555399,-0.008362962,-0.048988927,-0.017607985,0.0025740422,-0.0006261135,0.014291779,0.06638348,0.15723054,0.04201818,0.035955645,0.019675892,0.018247323,0.010619483,0.009132571,0.10940362,-0.06793046,0.072312534,0.0065612844,0.021326689,0.017974097,-0.032778155,-0.025898812,-0.052237306,-0.005880704,-0.02947822,-0.08329839,0.010209009,-0.033196248,0.02186091,0.045762215,-0.108465604,0.08469386,0.10343318,0.02171108,-0.010346333,-0.04737939,0.050108705,-0.073414244,0.05962221,0.046450563,0.02977171,0.0066564702,0.0020611438,-0.031920627,0.0690631,0.0114250425,-0.015030249,0.009339387,0.053461496,-0.0068097585,-0.09630082,4.1115622e-33,0.06671356,-0.092902,0.05261714,0.06734678,-0.029656822,0.015892573,-0.05412242,0.034207076,-0.00056665286,0.03768552,-0.066495895,-0.09635447,0.032178808,0.045505084,-0.06122659,-0.026934812,-0.07652905,-0.046397973,0.042748712,-0.030315531,-0.02222996,0.036396846,0.016132977,-0.040570974,0.014446993,0.053039704,-0.06918817,0.031545028,0.048754804,0.01054209,-0.08470927,-0.07139732,-0.03432692,0.00014088865,-0.0711762,-0.053386807,0.074349634,-0.07825741,-0.028277552,0.014477322,0.053867698,0.04793101,-0.13627148,-0.059608653,0.03529515,-0.12680277,-0.04599402,0.0695033,-0.0029713914,0.028001597,0.06650582,-0.10671563,0.11223841,-0.01982134,-0.043872263,0.07876444,0.0071927216,-0.007029772,0.03757385,-0.0017540127,0.0032330079,-0.0052074897,-0.03344887,0.042131595,0.04178631,-0.047298472,-0.035206266,-0.049142808,0.015334493,-0.04105515,-0.036534857,0.11109373,0.050872546,-0.031265058,-0.0201849,-0.07410888,-0.06441543,0.10445045,-0.031709936,0.047924194,0.0022833936,-0.027146203,0.014775303,0.021917032,0.029210655,-0.01610347,0.06886328,-0.08131374,-0.064333476,-0.036399204,0.029513648,-0.04616885,0.023292404,0.06338458,0.005891998,-4.6888515e-33,0.014780497,-0.07066618,0.07134245,-0.058008455,5.0368548e-05,0.026083961,0.029550456,-0.012528941,0.013016174,0.0019256733,0.039096292,-0.040188648,-0.0032111083,-0.0050370535,0.015017769,-0.021407235,-0.01464439,0.027882164,-0.030329833,-0.014328634,-0.11477269,-0.026162554,0.0359876,-0.012281119,0.08160064,0.017544443,-0.10657841,0.04751551,-0.014846963,0.05370911,0.007267121,0.016113702,-0.019862037,-0.009707045,-0.0005548903,-0.0004990899,-0.034880143,0.04980625,0.07532372,-0.04034229,0.03311016,0.04874821,0.030493125,0.015753832,0.031193854,0.11841629,0.021814585,0.016853452,0.0037161561,-0.08174462,-0.035991818,-0.061928216,0.005794576,0.1161848,0.022682078,-0.0006660378,0.07856859,0.014826543,0.0004886526,0.022991732,-0.012059805,-0.03133851,-0.016536899,0.028727066,0.085324705,0.05199962,-0.08308513,0.003873018,0.05863967,-0.048256136,0.07755497,-0.0125351455,0.033943348,0.011711318,-0.035843775,0.0041747424,0.013536343,-6.3414634e-05,0.036379423,-0.04068535,-0.081539534,-0.005480612,-0.02864635,-0.03421105,0.001486764,-0.06582512,-0.039099522,0.051643573,0.09472574,0.026620427,-0.08492328,-0.026246654,0.0598183,0.04918883,0.010125407,-4.1900535e-08,0.020691555,-0.07013872,-0.0050558597,-0.061909497,-0.05464809,0.009365424,-0.017687516,-0.032020066,0.038323972,0.0025260556,0.08455518,0.013575321,-0.013633947,-0.01618696,0.042021114,0.020012714,0.019947767,0.045205884,0.016849248,-0.052142162,-0.0533915,-0.032286774,0.06289769,-0.037426036,-0.025415985,-0.09883517,0.0168448,0.019137157,0.015571398,-0.031852026,-0.056513395,-0.0031654288,-0.02951525,-0.033710547,-0.04030943,0.0153014455,0.014175041,-0.0061724405,0.06044492,0.018023862,0.059461974,-0.051502045,-0.07149335,-0.05842108,-0.0015224563,-0.02509604,0.070884556,0.009647708,-0.030877132,-0.06146701,0.008201349,0.022865592,-0.052051358,-0.072995216,-0.07066601,-0.009513302,-0.0003930596,-0.0015092054,0.016383547,-0.07223252,-0.0024256413,0.040726516,0.16103545,0.03329935 +3.4.21.70,"A peptidase of family S1 (trypsin family) from pancreatic juice. Unlike elastases, has an acidic pI. Binds cholesterol",384,1.0,-0.05214778,-0.08111184,-0.11853486,-0.047806885,0.005453678,0.09289769,-0.0075351493,0.072925285,0.0481572,-0.03370462,0.061479673,-0.05761013,0.014596076,0.030745234,-0.07022575,-0.05860262,-0.008246974,-0.07702354,0.043300338,-0.085424796,0.02050161,0.027950086,0.019762259,0.050148517,-0.088234276,0.0007539852,0.022263242,-0.052001733,-0.04850293,-0.056110065,-0.035672728,-0.0834746,0.058186594,-0.052037757,0.030843953,0.005609455,0.06340176,0.042930994,-0.010185912,-0.023973836,0.10996638,-0.002370372,0.031810697,-0.045094736,0.028989308,-0.016012656,-0.0061192056,0.03167384,0.046238966,0.038376655,-0.066919975,-0.08321535,0.015428778,-0.050813224,0.05959338,0.050105665,-0.027439544,-0.043857258,0.036630925,0.04749447,-0.011021687,-0.035106342,0.06783634,-0.0009814855,0.0046241246,-0.0653427,0.027067132,0.0074103097,-0.026155574,0.0042635845,-0.08048279,-0.032391816,-0.12738785,0.1400574,-0.030667653,0.071239695,-0.02598947,-0.074281484,-0.052775566,-0.0111095,-0.044824023,-0.05047589,-0.041426018,0.12456934,0.0096573215,0.043128926,0.034988474,0.027924422,-0.02806882,-0.06651274,0.05638256,-0.0937144,0.055310078,-0.01550482,-0.032450914,-0.022030799,-0.05458932,-0.09095517,-0.044635903,-0.008331967,0.056907985,0.00055778696,0.05407883,-0.09437821,-0.022510521,0.021821836,-0.07798174,0.0007785438,0.09320964,0.01810815,0.037132632,-0.044394676,0.07106519,-0.026575787,0.015723156,0.06685272,0.010226973,-0.031259283,-0.058710963,0.0077263694,0.04998586,0.0057295184,-0.0111088855,0.04940133,-0.01769824,0.032159023,-0.03855297,1.2709633e-33,0.03784882,-0.048132833,0.05288171,0.058917448,-0.030992992,-0.0018630135,-0.046413563,0.047950275,0.008922538,-0.03862408,-0.08436301,-0.037071925,-0.009931493,0.03799108,-0.07690925,0.027921068,-0.03931542,-0.03237905,0.03887001,-0.015987063,-0.08642905,0.11752854,0.00026666987,-0.08254619,0.053288825,0.015948236,-0.02501363,-0.022500077,0.06480553,-0.020438775,0.004525316,-0.0064681643,-0.08451985,0.046928752,-0.004280188,0.02995674,0.08048455,-0.071804464,-0.014728087,0.022196412,0.015383895,0.020616286,-0.022727046,0.012510033,0.07304798,-0.008999813,-0.040803015,-0.006186081,0.04902873,0.017046431,0.022281166,-0.044503503,0.096983604,0.035113253,-0.041427,0.011610266,-0.010975002,0.023960661,0.05309663,0.034437757,0.033012003,0.07231084,-0.070093066,-0.004566087,-0.047964007,0.04574751,-0.049449127,-0.04764517,-0.018443707,0.0654828,-0.00026068126,0.032503355,0.070981555,0.015746186,0.053320695,-0.060621984,-0.03278323,0.08890105,-0.030755578,0.0360369,0.008047763,-0.056316074,-0.016765298,-0.02663589,-0.08423876,-0.0028526937,0.0014314286,0.02163811,-0.035757072,-0.00428635,-0.031958226,0.044634957,-0.01567671,0.104698315,-0.043809287,-2.3532495e-33,-0.029220687,-0.13074043,0.0909986,-0.0020607759,-0.004354049,0.02947807,0.040666755,-0.04332809,0.037512936,-0.07302226,0.011306671,-0.060646106,0.08568668,-0.06682994,0.06521441,0.05345663,-0.039090488,0.044329047,-0.017427431,-0.044857655,-0.09240646,0.06319907,0.02098403,0.14018594,0.066641316,0.055372458,-0.015123194,0.0008510687,-7.587487e-05,0.01844916,0.004977523,-0.04730481,-0.09475362,-0.040565312,-0.08961067,0.0048692673,-0.0624127,0.012343836,-0.016063852,-0.016809793,-0.016152924,0.07827486,0.10727995,0.045237303,0.0050181015,0.05485136,-0.021305015,0.035710357,-0.01863997,-0.03355505,-0.032141343,-0.002272435,-0.005933217,0.050623644,0.08904428,0.024845334,0.051293686,0.035982102,-0.04401512,-0.052588217,-0.083017744,-0.024596328,-0.019099237,0.0094058355,0.050762065,0.05643576,-0.024994927,-0.0370759,0.012643174,0.022403095,0.06808265,0.0027641393,0.065727934,-0.04217031,0.013203166,0.06262776,-0.11222394,-0.053956714,-0.0322925,-0.079445936,-0.02819981,-0.027385999,0.0063995477,-0.02955655,-0.02968012,-0.041040227,-0.006841165,0.045935687,0.09806574,0.041452203,0.00235861,0.008691095,-0.022770146,0.032625075,0.031808726,-2.653139e-08,0.123055376,-0.053965006,0.05677116,-0.0015155928,-0.08586192,-0.038920622,0.025678406,0.041847084,0.038174123,-0.015648909,-0.027400808,0.08740249,-0.013815268,-0.02070584,0.020494608,0.06361995,9.5708274e-05,0.080283724,0.014621642,0.05798909,-0.052776486,-0.001886271,-0.02530056,-0.0137304,-0.06263958,-0.04054897,0.022596238,0.052126184,0.030800479,-0.07653741,-0.0071448763,-0.0371683,-0.036318034,0.018092932,0.014944308,0.019599361,0.0063957702,-0.007393368,0.017284833,0.078901835,0.009010348,-0.065689534,-0.040798582,-0.051951505,-0.1045141,-0.018171836,0.051659103,0.03493639,-0.0019114661,0.021275181,-0.058052875,0.012274797,-0.021676539,-0.02847475,-0.029878162,-0.031547837,0.004756143,-0.036749367,0.015394739,0.01809782,0.037581515,0.0651249,0.21788862,0.108291835 +3.4.21.71,"A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II",384,1.0,-0.042069066,-0.04138561,-0.096436925,-0.021617616,0.047013827,0.08521093,0.03266022,0.08078254,0.023757387,-0.00058648025,0.048858736,-0.088249475,-0.031367987,0.077686064,-0.09331724,-0.0615105,-0.08153827,-0.093167156,0.06625313,-0.07650699,0.056612052,0.05315548,0.045704905,0.08719111,-0.053495105,-0.044776287,0.01316471,-0.01055452,-0.012907923,-0.021126121,-0.0909993,-0.14329484,0.086025044,-0.01709636,0.04692561,0.010445116,0.025472559,0.048839893,-0.009585653,-0.003404028,0.11870554,-0.030362185,0.015740944,-0.07953086,0.025517596,-0.0011200245,0.010024292,0.03660342,0.025871981,0.054711457,-0.026230248,-0.07454321,0.012887341,0.0059893616,0.09453888,-0.0008333655,-0.04700453,-0.040319283,0.017994689,0.021873787,-0.008246057,-0.0040128753,0.05624171,-0.010479244,0.09272926,-0.004202994,0.013546584,-0.022383116,-0.04613913,0.0017955167,-0.06966353,-0.038304534,-0.08375628,0.13860458,-0.049900513,0.06089188,-0.009681354,-0.023780549,-0.066622846,-0.024448134,-0.03161971,-0.011951971,0.0005750742,0.04062033,-0.03934722,0.019692907,0.028172014,0.0073247477,0.0055089593,-0.09361482,0.03259064,-0.13747476,0.03628622,-0.025530957,-0.009907296,0.010974974,-0.06775461,-0.09694751,0.019195091,0.0014104993,0.015233653,-0.013256138,0.044289038,-0.110649146,0.0013061168,0.06292839,-0.08012867,0.008719636,0.07744248,0.02070705,0.020817306,-0.035861064,0.06915517,0.039016716,0.03723539,0.09319894,-0.01697813,0.024069488,0.016827563,-0.0064291083,0.03125131,0.0010601997,0.017105782,0.030161522,-0.0004053293,0.034431253,-0.08976746,1.4837017e-33,0.02909243,-0.0381147,0.009218758,0.0931034,-0.016529078,-0.012952146,-0.04147203,0.050021973,-0.051244747,-0.07000267,-0.10831349,-0.063822955,-0.008382984,0.034887098,-0.053155076,0.02262489,-0.021877896,-0.044403452,0.05582337,-0.038853988,-0.08082188,0.11877862,0.038277064,-0.09949157,0.07327347,0.046448506,-0.014250567,-0.0029884677,0.042088937,-0.030065063,7.45527e-05,0.034532532,-0.0683475,0.061513636,-0.016018204,0.0031256198,0.10118346,-0.08584675,0.020605767,0.06250801,0.03166188,0.008718095,-0.022156987,-0.036875922,0.10309107,-0.0442292,-0.026311642,0.008157856,0.04553993,0.014813606,0.032381024,-0.0276132,0.056514468,0.000754653,-0.055568583,-0.018305583,-0.01775158,0.017307011,0.08816759,0.045555264,0.030053632,0.04267643,-0.012601685,0.0070624026,-0.0077009154,0.045255452,-0.04888492,-0.021946598,0.0016077247,0.03462341,-0.019627005,0.030010851,0.090557754,-0.012557892,0.054536745,-0.07481414,-0.026933594,0.06037761,-0.013858371,0.039291177,-0.033681713,-0.028982356,-0.0026341924,0.0033703498,-0.07900474,-0.036483172,0.013319316,0.0033674883,-0.062453892,0.011107674,-0.043052662,0.061515372,-0.032970365,0.07826521,0.0010960038,-2.8023168e-33,-0.027541224,-0.099554256,0.10122119,-0.045466486,-0.03504646,0.0021654465,0.028801192,-0.06343886,0.0029638119,-0.011907443,0.05899642,-0.100526825,0.12668712,-0.080569126,0.051500242,-0.010176505,-0.057090033,0.028298687,-0.01633909,-0.06572004,-0.04974308,0.045861185,0.0025735935,0.048032086,0.08352702,0.04912794,-0.020428343,0.08995474,-0.03275414,-0.0085462155,-0.059146345,0.013430714,-0.08688549,-0.03437308,-0.029756768,0.0024370113,-0.046701163,0.03417747,-0.006801308,-0.05059998,0.011393627,0.063627,0.09473521,0.050662585,-0.0074532754,0.048687275,0.032012377,-0.0073206285,0.008586191,-0.06942789,-0.026627315,-0.027461972,-0.032948244,0.0074670706,0.053079627,0.008825053,-0.0100848535,0.022634111,-0.05372098,0.009455212,-0.03759362,-0.04033546,0.015004741,0.031463027,0.08416449,-0.0057581505,-0.0703311,-0.056828275,0.031255,0.07240056,0.11495678,-0.060611386,0.05105144,-0.02382311,-0.02057151,0.05109691,-0.077959806,-0.031483248,0.006824767,-0.08713186,-0.0007383757,-0.071776085,0.03634295,-0.006847201,-0.037729055,-0.048327807,0.004429281,0.09518685,0.066646755,0.04185983,-0.023545992,0.037323516,-0.014434312,-0.011648821,0.0065669403,-3.2736097e-08,0.092416674,-0.05693541,0.046068568,-0.0397233,-0.032705374,-0.022867892,-0.0032683106,0.02251415,0.036423594,-0.057242278,-0.085971944,0.007304348,0.03389048,-0.05620173,0.039376207,0.042040866,-0.042192407,0.1188215,-0.007285153,0.04371324,-0.02774748,-0.04692502,-0.06715529,-0.030138433,-0.08789822,-0.060389068,0.0046819504,0.08667793,-0.011601414,-0.06680466,-0.016637037,-0.019038716,0.00129685,0.035617005,0.029550154,0.060170915,0.008396625,0.0060422947,-0.00945947,0.019363113,0.030651174,-0.08206282,-0.023923257,-0.032872353,-0.065144025,0.0049901996,0.04943741,0.03321239,-0.011011923,-0.013274339,-0.032803852,-0.009672278,-0.022682864,-0.017457124,-0.04257761,-0.010763359,0.0011554429,-0.014590986,0.012282038,0.036707163,0.030532472,0.05632089,0.18525462,0.07808748 +3.4.21.72,"Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase)",384,0.99999994,0.0005975873,-0.06692287,-0.06585974,0.007941829,0.037333872,0.059930578,-0.027544213,0.06741555,0.032905836,0.022763047,0.08948733,-0.10059485,-0.05668214,0.102259226,-0.019721577,-0.0825301,-0.048988137,-0.05181877,-0.00867286,0.014986321,0.09080153,0.09977615,-0.023697894,-0.0111223385,-0.09621605,-0.0015156913,0.010094537,-0.05269909,0.023552759,-0.053310264,-0.0076330137,-0.030930286,0.029920641,-0.035524145,0.11128925,-0.03241016,-0.075070776,0.0752204,0.06333877,-0.024407491,0.03540777,0.056404717,0.05672438,-0.014626513,0.007041277,-0.014941932,-0.032790158,0.09618853,0.026528958,-0.025922086,0.024949854,-0.084504195,-0.040760584,0.034782868,0.053010903,0.004895119,-0.044246253,-0.07716871,0.039281823,0.020998653,0.06262136,-0.04029195,0.008119921,-0.05845067,0.005111138,0.027918566,-0.0009760215,-0.040502317,0.044891823,9.204328e-05,-0.018441435,-0.024918843,-0.09192862,0.09336844,-0.008491308,0.16143891,0.024010336,-0.018447874,-0.046160404,-0.054547768,-0.05653799,0.00018990478,0.07557634,0.036969792,0.061423987,-0.00027299847,0.029070998,0.052846916,-0.0141556375,0.014494839,0.020559594,-0.07967675,0.014670379,-0.10568361,-0.053190548,-0.01870216,0.00034684732,-0.013983787,0.010824029,-0.032110546,0.026248926,-0.03767752,0.00010680642,-0.029262213,0.049324546,0.029072447,-0.060644414,0.0017273024,0.07484605,-0.05082932,-0.04619562,0.04106275,-0.0113816885,-0.1127288,0.025294695,-0.073348425,0.039648343,-0.0006105857,-0.05055259,0.04200586,0.00885,-0.014342711,0.011321269,0.01742481,-0.007553211,0.01472236,-0.104747415,4.938436e-33,-0.020143492,-0.056196347,0.046403944,0.015966162,0.05048353,0.027727546,-0.034059413,0.0025352049,-0.03208372,0.020962281,-0.05414222,-0.03482671,-0.049624737,0.0048730527,-0.00927132,0.08160199,-0.083092265,-0.012184277,-0.005282824,0.008254214,0.036928456,0.12152972,0.02493846,-0.069206305,0.10592451,0.030255452,0.009191481,-0.066805854,0.021354118,-0.012348557,0.007199799,-0.033878095,-0.050458595,0.012843675,0.0317611,-0.007815868,0.051056977,-0.11232683,0.008888677,-0.063038245,0.023426374,0.09606986,-0.099675424,0.049031407,0.08126394,-0.07085675,0.009384473,0.029659655,-0.052818038,0.023145374,-0.001666593,0.0046855146,0.05043746,-0.043806102,-0.018999385,-0.021293003,0.02861619,0.12226223,0.123977445,0.056434218,0.06878303,0.099833116,-0.061151646,-0.06117446,0.015320278,-0.009738575,0.00783069,-0.008079225,-0.0066811857,0.089507386,-0.023300337,0.016452407,-0.011559553,0.011484835,-0.04083391,-0.0559518,-0.08498604,0.0047369953,0.06367073,-0.045962725,0.014932438,0.036443394,0.03994654,-0.029363692,-0.10856659,-0.015647879,-0.017574558,-0.012601939,-0.05254443,-0.00852401,0.10883121,0.03530661,-0.037920732,0.084082186,-0.050387233,-4.5734867e-33,-0.05971718,-0.035196688,-0.045438163,-0.057841808,-0.03396076,0.06859935,-0.014140704,0.002550775,0.013112625,-0.06305551,0.1003804,-0.0105134845,0.049916856,-0.052428786,-0.013770628,-0.012771929,0.013514025,0.09843598,0.06662057,-0.04427516,-0.06943941,-0.025159342,-0.02674634,-0.053258963,0.097529285,0.07022287,-0.07408516,0.10704301,-0.05252075,-0.020233652,-0.010761222,0.088732496,0.025869654,-0.10494184,-0.08830714,-0.031432122,-0.08410462,0.04200421,0.08012531,-0.0021229917,-0.0007609448,0.037587352,0.09632918,0.12188557,-0.018619426,0.045538217,-0.06204579,0.04584895,0.1009874,-0.026077237,-0.029168906,-0.11492523,-0.026738955,0.0402513,0.01209006,-0.05345653,0.015139797,-0.03519536,-0.05889409,0.023486808,0.0103159975,-0.018899685,0.002906035,0.011320926,0.061355796,0.0075693633,-0.048424296,-0.037195023,0.020517439,-0.006572086,0.040556192,-0.015978595,-0.015044979,-0.059584986,0.0029627758,-0.01804478,0.0017745716,-0.037141062,0.054876164,0.0027337964,-0.03381604,0.028647432,0.016452383,0.039583307,0.0777223,-0.07979841,0.004524901,0.06460539,0.020027462,0.090856716,-0.036161505,-0.0029499778,0.029425208,0.0068412055,0.01620723,-3.6887112e-08,0.061095536,-0.07275283,0.036141828,-0.08390595,0.002808281,-0.040039055,-0.069845125,0.014323446,0.044781808,0.011895348,0.06627578,-0.01903669,0.022175655,0.009006041,0.060771335,0.048910532,-0.01985382,0.004948741,0.006452903,0.01983268,-0.0722999,-0.016403541,-0.027517194,-0.032262973,0.0058034193,-0.05239826,0.032833233,0.0039515886,-0.031584196,-0.017050268,-0.03007265,0.0060381345,-0.03148524,0.008085495,-0.008174305,0.08809102,-0.04324274,0.030460665,0.0011850494,-0.015103626,0.03160017,-0.045649987,-0.090391874,-0.0055078357,0.02516019,-0.00151926,0.06480373,-0.013238917,-0.028854296,-0.022523653,0.026546773,-0.035392027,0.0067548985,-0.01276844,-0.1072322,0.008844481,0.0316437,-0.033616327,0.052416876,-0.047936555,0.017624205,-0.070799425,0.1425247,0.08276046 +3.4.21.73,"Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26",384,1.0,-0.1379172,-0.14166306,-0.072733186,-0.028066782,0.06030017,0.071046576,0.0004824426,0.13481396,0.10338307,0.02390009,0.0757888,-0.048325267,-0.012100357,0.08897035,-0.039358824,-0.03531742,-0.025019575,-0.09395325,0.062441755,-0.071618594,0.02425877,0.042107727,0.011204108,0.017414084,-0.029405164,0.044365644,-0.02888621,-0.03835296,0.07106883,0.026595864,-0.0574713,-0.05716439,0.029927446,-0.035874598,0.039257415,0.017521,-0.015129881,-0.013452496,0.02850206,0.006678565,0.04418334,-0.03033548,-0.043119647,-0.08585344,0.0353219,-0.0100659495,0.0466293,0.1061146,0.0059132543,0.04153758,-0.005380207,-0.0663822,-0.017742554,0.0025404373,0.07804142,0.032036107,-0.105895706,0.009143074,0.016240394,0.056540567,-0.034786005,0.030664274,0.061564572,-0.005495752,0.008186598,-0.02541961,0.032283816,-0.002133723,0.011366836,0.034693897,-0.009994259,-0.0067630564,-0.05611992,0.10567485,0.036536366,0.031206233,-0.0031112146,-0.013755609,-0.07983774,-0.06124606,-0.012621474,-0.013918212,0.030445071,0.1065519,-0.037990768,-0.033079077,0.015610836,0.010466867,0.007550437,-0.00815027,0.04233357,-0.025434807,0.016664436,-0.01606149,0.000425762,0.050679125,-0.080278,0.052392755,0.028093373,-0.013862825,-0.031792942,0.00088055123,-0.03293709,-0.06303406,-0.017229788,0.00816148,-0.035806667,0.012456021,0.043272663,0.028739944,0.004282341,-0.055275794,0.03821658,-0.05132505,0.01256915,0.008393205,-0.0024108235,-0.016162599,-0.011873825,0.050832737,0.07604842,0.000310784,0.00672756,0.087510034,-0.015102386,0.021606555,-0.044449557,4.8166294e-35,0.054734785,-0.03353806,0.03380415,0.045064304,-0.0100423,-0.004619789,-0.019199513,-0.014579986,-0.027130108,0.0004758653,-0.08940772,-0.06220122,0.00023012025,-0.023101065,-0.05458254,-0.038195267,-0.05843242,-0.017719606,0.04586105,0.056218155,0.036713798,0.11252997,0.036490776,-0.056634706,0.015204091,0.054302655,-0.028124737,0.02362028,0.03431336,0.0024624418,-0.064692535,-0.08961692,-0.0947673,-0.05498272,-0.04996795,0.0020046444,0.00047666347,-0.05028152,-0.051502742,0.0040359767,0.05225463,0.027816178,-0.09946422,-0.046190757,0.05154428,-0.042092945,-0.038520705,0.057351243,-0.00018716042,0.00804384,0.036094256,-0.039369296,0.11093566,0.02534646,-0.047032785,-0.00517727,-0.039361384,0.00818892,0.032194395,-0.0048602684,0.10228684,-0.00017609434,-0.046191573,0.028414471,-0.0062484317,0.04278053,-0.00066035066,0.0015587491,-0.00066186575,-0.017848529,0.0117405085,0.06272052,0.007149638,0.0057221474,0.10014291,-0.09044999,-0.051164165,0.0632727,-0.042087957,0.039487693,-0.04602154,-0.013136546,-0.0049824426,0.014937388,-0.06423498,-0.02921721,0.022538735,0.033997938,-0.06202586,-0.060195893,-0.03159947,-0.06225947,-0.015389581,0.11194209,-0.036396075,-1.7329198e-33,0.011870573,-0.05663127,0.07500527,-0.05063883,-0.021182511,0.056978215,0.017584438,0.05880946,0.07383314,0.011831365,0.06157961,-0.07886853,-0.035585456,-0.07430446,0.005226054,0.02786338,-0.08910119,0.05108674,-0.034900095,-0.065253794,-0.08347176,-0.026855897,0.04378226,0.09654083,0.02591839,0.042801253,-0.06594302,0.073394984,-0.07138483,0.06621267,-0.05220537,-0.052868318,-0.09721435,-0.022821987,-0.078437835,-0.011466037,-0.032945998,0.011957407,0.06323658,-0.0912521,0.08823109,0.13641977,0.12210077,0.09583815,0.00019242223,0.13717137,-0.0075090434,0.009039379,0.009462615,-0.084989704,-0.033627044,-0.022645041,0.024376435,0.03396847,0.050527174,0.063396096,0.040360015,0.09288168,-0.032172233,0.039804086,-0.022295568,-0.104988106,-0.03151364,0.06911099,0.073585585,0.010776458,-0.041562367,0.08219926,0.06592805,-0.031007545,0.08305904,-0.03126781,-0.009743375,0.030113459,0.059494752,0.032767896,-0.012141256,-0.034356173,-0.0031773464,-0.04732992,-0.0027042856,-0.043048035,-0.07103688,-0.041418947,-0.0007941637,-0.04996354,0.06927003,0.008316335,0.06119274,0.009553948,-0.038576216,0.009061185,0.020238087,0.050754823,0.010843359,-4.13919e-08,0.095236905,-0.06565455,0.009545301,-0.03752909,-0.009295235,-0.021519525,-0.03770393,0.058400765,0.020366957,-0.06400397,-0.012003732,-0.0173318,-0.013485693,-0.025516909,0.06263156,-0.0060879444,-0.059506048,0.06668733,-0.015531087,-0.054064002,-0.015332165,-0.027434012,-0.015818836,-0.004094748,-0.032033272,-0.010804079,-0.034789953,-0.022861788,-0.054140117,-0.033720996,0.0024054456,0.02460394,-0.03400317,0.016811332,-0.05047591,0.018272897,-0.041038528,0.017988378,-0.033351235,0.0642292,-0.04829919,-0.07226179,-0.046649355,-0.08087975,-0.0069562453,0.029961228,-0.009791778,0.07731741,-0.009594084,-0.062927336,0.02062831,0.0056297295,-0.032300778,-0.07771275,-0.097287335,-0.038376007,5.1928855e-05,-0.04136449,0.07100564,-0.10724586,0.011500647,0.028405437,0.15873447,0.10158795 +3.4.21.74,"A somewhat thrombin-like enzyme from venoms of snakes of the viper/rattlesnake group. Species variants of the enzyme include ancrod from Agkistrodon rhodostoma (Malayan pit viper) (formerly EC 3.4.21.28) [1], batroxobin from Bothrops atrox (South American pit viper) (formerly EC 3.4.21.29) [2,5] and crotalase from Crotalus adamanteus (Eastern diamondback rattlesnake) (formerly EC 3.4.21.30) [3,4]. In peptidase family S1 (trypsin family). Does not require activation by Ca2+.",384,0.99999994,-0.10096518,-0.009053233,-0.11857327,0.00057490054,0.0007231948,0.045536846,0.018485319,0.057948537,0.0012458386,-0.0038369223,0.007173918,-0.13055725,-0.023558047,0.13391584,-0.08958951,0.018754372,-0.0030357994,-0.02272202,0.07088605,-0.10967691,-0.017088717,0.037261244,0.021441853,0.069480844,-0.061841868,0.006730118,-0.059258115,-0.02365367,0.009613156,-0.049269084,-0.08574583,-0.06616542,0.039982393,-0.07586397,0.080664665,0.034947086,-0.071749285,0.023022475,-0.02626413,-0.0450049,0.0843954,0.0636987,-0.009272205,0.009979864,-0.050574046,-0.037259046,0.0102087585,0.075915605,0.06916508,0.028585183,0.0007402451,0.006178525,-0.05137766,-0.0010595608,0.055045772,0.024453662,-0.0532257,-0.04065307,0.035514962,-0.029049313,0.04460701,-0.005759347,0.045465894,0.0444204,0.022613054,-0.06804806,0.0034808519,-0.009935251,0.03580778,-0.031372435,-0.04118581,-0.05933604,0.0188207,0.07633266,0.024479348,0.07700632,0.09022308,0.0023236729,-0.014571806,-0.0695353,-0.056921016,-0.003637432,0.09869937,0.044877466,0.040357333,0.047855787,-0.006987789,0.021345675,0.025239773,-0.00374293,0.14705002,0.009161013,0.03049773,-0.06697476,0.035154413,0.026325902,0.033164054,-0.006686477,-0.028779093,0.0008939112,0.053242564,-0.036416028,-0.033839706,-0.049635097,0.019218381,0.012014643,-0.08268517,0.027707085,0.100670174,-0.0064380257,0.011897578,-0.011454574,0.0875148,0.0029857524,0.034447428,0.04113512,-0.057413418,0.0013080512,0.03270553,0.027883528,0.040269237,-0.054611284,-0.02912997,0.00010457118,0.040308617,0.021598218,-0.20018776,4.8373176e-33,0.053191666,0.013384486,0.012277023,0.038121153,-0.03465902,-0.031389277,-0.11263162,0.005607499,-0.0819151,-0.0074303397,-0.051359724,-0.079005346,0.011537038,0.021165408,-0.044880517,-0.011712397,-0.09577748,-0.034516823,0.045789264,-0.036389504,-0.039710134,0.040950246,-0.037301876,-0.011124921,0.079908036,0.07073734,-0.044395674,0.01011809,0.0510435,0.016018802,-0.030465912,-0.085346945,-0.053875737,0.05414642,-0.042146314,-0.017429609,0.08198016,-0.065513134,-0.05350111,0.02999674,0.041538443,0.030465297,-0.06784249,-0.056449942,0.10621614,-0.12247061,-0.075236104,0.08513166,0.036807656,0.052212387,-0.0068288785,-0.07246339,0.1560464,-0.028699247,-0.095381126,0.04842057,-0.009363571,0.020564869,0.048433278,-0.029857138,0.040378068,0.026428841,-0.008641892,-0.012194477,0.042680815,-0.00838618,-0.021133685,-0.08094342,0.0019671733,-0.024381982,-0.018080661,0.09054582,0.07259997,-0.04253789,0.033858344,-0.06401271,-0.01683979,0.0717371,-0.050952874,0.06865743,-0.015724577,-0.028452883,0.014323098,0.0104362145,-0.009074653,-0.040669095,0.050789885,-0.07042996,0.018911824,0.018449228,0.040930986,-0.05131452,-0.05205003,-0.009683772,0.008711637,-3.4699407e-33,0.01561236,-0.025439452,0.11584542,-0.04454342,-0.0016246166,0.047335703,0.055053364,-0.0016580642,0.0263738,-0.10437139,0.045752294,0.009358004,0.021460745,-0.04274696,0.017974414,0.052859,0.024122441,0.06642143,0.013260983,-0.017092302,-0.057677407,-0.022323892,0.0062549086,0.038416035,0.06562029,0.055982005,-0.033459254,0.040998418,0.027051298,-0.016330747,-0.04137432,0.07983897,-0.049106862,-0.016168958,-0.06816613,-0.05713615,-0.052789107,0.02090802,0.023278417,0.012002699,0.054285638,0.06842557,-0.008061639,0.05363767,-0.005634447,0.10644815,0.01003958,0.07063983,0.012799915,-0.062332027,0.016399186,-0.021464033,-0.027975703,0.05855121,0.03942657,0.013801017,0.06574391,0.058119547,-0.016846206,0.024779078,-0.030426407,-0.023194592,-0.04308964,0.044226915,0.059875585,0.113657646,-0.060510557,0.011554497,0.019420374,-0.012892106,0.107304424,-0.044706255,0.019480828,-0.017543891,0.010289071,0.04084722,0.008085846,-0.078449704,0.023074694,-0.07258967,-0.03377191,0.0368972,0.019710358,0.019597523,0.031643003,-0.009459362,-0.04029886,0.077806085,0.04270591,0.0083126975,-0.01985267,0.0082969405,0.017375609,0.012628783,0.10452591,-4.981716e-08,0.06043012,-0.091617145,-0.024472669,-0.09753151,0.006126874,0.07471758,0.015719319,-0.041257475,0.022460792,-0.0065524126,0.020871922,-0.058204472,0.013534515,-0.03128311,0.063839026,0.053451095,-0.0043278607,0.026036588,-0.025742406,-0.06235821,-0.0646953,0.035272192,-0.03040115,0.040040467,-0.06962197,-0.04909386,-0.035623446,-0.03564528,0.050498296,-0.033370722,-0.06314419,0.012280961,-0.03488307,-0.05012042,-0.019994905,0.035857394,-0.022131449,-0.021430634,0.024897443,-0.0074523003,0.040539704,-0.03309264,-0.024532555,-0.038824048,-0.07070273,-0.0691972,0.014825022,0.009461513,0.022914372,-0.09026708,0.025740195,0.028878698,-0.030877227,-0.12381671,-0.101087704,-0.009860829,0.025368875,-0.050411277,-0.00063136657,-0.018434355,0.044458862,-0.031112215,0.11560745,-0.011886179 +3.4.21.75,"One of a group of peptidases in peptidase family S8 (subtilisin family) that is structurally and functionally similar to kexin. All are activated by Ca2+, contain Cys near the active site His, and are inhibited by p-mercuribenzoate. At least three related enzymes are recognized in mammals: PC2, PC3 and PC4, which have somewhat different specificities",384,1.0,-0.028710095,-0.03261123,-0.07539153,-0.06168034,0.062184338,0.047278248,-0.04763885,0.058843903,0.06600548,0.024037058,0.04645149,-0.04480442,0.010661383,0.13151939,-0.032663498,-0.02477467,-0.06272942,0.020322483,0.040570114,-0.09337419,0.047777396,0.010132473,0.026212463,0.07136012,-0.07759358,0.036818404,0.050524052,-0.005383338,0.01912143,-0.013727102,-0.043613452,-0.057074144,0.0655347,-0.046103124,0.08271274,0.041432742,-0.044764917,0.009638949,0.046104882,-0.031462263,0.045883145,-0.02997849,-0.004618401,-0.042196408,0.08870489,-0.03311324,-0.02068293,-0.012911017,0.062472217,-0.051889557,-0.01327134,-0.08452421,0.018937761,0.025716478,0.00036125229,0.0045253895,-0.056055572,-0.017672088,0.093950085,-0.036172334,0.011279814,-0.0051861824,0.039835174,-0.0112464605,-0.0001336106,-0.020227691,-0.0126761785,-0.01294762,0.008654533,0.015060844,-0.031410284,-0.03795594,-0.066719025,0.09174588,-0.0019362593,0.005890082,-0.017136564,-0.047859006,-0.06251321,-0.060445182,0.063075095,0.024210397,0.049935333,0.08497906,0.04380293,0.000995989,0.025880603,-0.0068235863,-0.0031020893,-0.089915745,0.07426544,-0.034203667,0.06759104,-0.046181053,-0.023064489,-0.0075464635,-0.0058403383,0.0025189382,0.035753332,-0.026699185,0.03884013,-0.002226436,-0.08096968,-0.024646087,-0.000613956,0.09242598,-0.055754464,0.05844524,0.058011238,-0.037003156,-0.03359153,-0.015572157,-0.020921644,-0.072285734,0.05383131,0.06371645,0.0692318,0.04809214,0.04586381,-0.0019819357,0.0023796577,0.005183965,0.04343917,-0.017246943,0.033945173,0.026208354,-0.14831929,2.3790661e-33,0.022961725,-0.009802825,0.022793485,0.043910213,0.036780883,-0.057639547,-0.04864127,-0.043078266,-0.018529397,-0.049786318,-0.10647049,-0.025812292,-0.020591302,-0.019491715,-0.03688664,0.025982883,-0.034296796,-0.061804954,0.03969737,-0.014375662,0.009456368,0.045886885,0.04965614,-0.022721257,0.098117396,-0.007458221,0.012013646,-0.02904476,0.0058094785,-0.038820073,-0.061319727,-0.020143216,-0.11439257,0.029051078,-0.029345743,-0.020009818,0.09861885,-0.07273964,-0.022032032,0.03569323,-0.05054273,-0.004457084,0.0020671687,-0.12229975,0.03856038,-0.054557756,-0.10911781,0.041636575,0.02650262,0.04664664,0.08009518,-0.0382458,0.045710698,-0.018213874,-0.0929821,0.0166627,0.028104672,-0.030506913,0.08449569,0.034750007,0.07166491,-0.056578465,-0.039997455,-0.007287452,0.023943769,0.012725344,-0.06200217,-0.013802804,-0.021015394,0.09222253,-0.09472809,0.03257709,0.04598735,0.020616794,0.04844364,-0.109420314,-0.12962162,0.072000414,-0.008083345,0.12556563,-0.03048849,-0.008691489,0.0352659,0.05806208,0.002306607,-0.023582852,-0.009918144,-0.02767141,-0.042397767,0.008995104,0.0041088266,-0.0814001,-5.956242e-05,0.058834765,-0.032791376,-4.5399406e-33,0.07407688,-0.014880958,0.05758471,-0.050442435,-0.07628457,0.07129876,0.002395246,-0.020573245,0.049503624,-0.015429981,0.038198642,-0.0072250003,0.030446248,-0.038304627,0.03129051,0.06607504,-0.031100223,0.094254605,-0.008080745,-0.07761829,-0.06858557,0.007892293,-0.01695828,0.03449543,0.08938912,-0.0053889807,-0.009553079,0.09562734,0.039738458,-0.017307427,-0.09583412,0.051059123,-0.05598287,-0.003404227,-0.033050295,-0.018565899,-0.07255801,0.007458401,-0.0018504296,0.015607363,-0.006567062,0.066543505,0.026850075,0.15245262,0.00488333,0.057690486,0.013547853,0.021175964,-0.031994816,-0.051091775,0.023074845,-0.047345363,-0.009355987,0.015129129,0.041131854,-0.005730861,0.0033808688,0.06508331,0.006344416,0.03672753,0.0018437498,-0.0377767,-0.047369756,0.03762982,0.034974277,0.07520261,-0.10391582,-0.006909516,0.08557604,-0.017466668,0.08183188,-0.069999516,0.02048789,0.014233858,0.0134773115,0.03646987,-0.08808627,-0.004289666,0.046239514,-0.03216974,-0.01854101,-0.04189659,0.0031072306,-0.021774227,-0.026304632,-0.036189094,-0.0005528986,0.09091678,0.06339352,-0.020614216,0.025298385,0.012160956,0.034412865,0.05137659,0.03911509,-4.1524086e-08,0.058961675,-0.048144717,-0.022234952,-0.10088589,-0.04445708,0.0134461215,-0.03357562,0.025962839,0.01834905,-0.06378006,0.005651271,-0.023143329,-0.016543368,0.053440567,-0.012047961,0.1083277,-0.010539491,0.0705652,0.0017570992,0.021895723,-0.10703322,0.0075170076,-0.09363237,0.06718701,-0.031160373,-0.065507814,-0.001797478,0.07363206,-0.02758935,-0.04350352,-0.012533228,0.005296651,-0.044862714,-0.057119306,0.021335842,0.040524535,-0.026287938,-0.05566371,0.026647821,-0.020691842,0.022468897,-0.096376464,-0.1015554,-0.045152787,-0.004093306,0.029944066,-0.014079772,0.007800671,-0.035054453,-0.07558987,0.01920801,-0.02552307,-0.017233457,-0.08054045,-0.13186096,0.031393223,0.024312872,-0.06208143,0.047194794,-0.1356138,0.029620383,-0.00024225989,0.1769219,0.009879469 +3.4.21.76,From polymorphonuclear leukocyte granules. In peptidase family S1 (trypsin family). Not inhibited by secretory leukocyte proteinase inhibitor,384,1.0,-0.061282143,-0.022163581,-0.05327323,-0.060295492,0.029301388,0.08268129,0.014042408,0.1159052,0.064163856,0.050776508,0.00077897013,-0.03098999,0.010463837,0.109171264,-0.0683954,-0.0100181075,-0.01099034,0.068178035,-0.037649814,-0.103801996,0.08312479,-0.0034895283,0.014557032,0.018250415,-0.055575464,0.0007511897,-0.02830985,-0.037292507,-0.004597702,0.03914662,-0.07630641,-0.078300096,0.006541047,-0.024749441,0.06257921,0.004269599,-0.024646169,0.043954547,-0.0043761022,-0.017862335,0.07886826,-0.005520117,-0.06404391,-0.074556954,-0.026892712,0.0016159707,-0.0044566207,0.064619154,0.065848224,0.04423253,0.021236576,-0.03489645,0.0657533,-0.020998226,0.013558449,0.037851267,-0.05785819,-0.03117483,0.07953987,0.025865532,-0.07059128,-0.027377773,0.08393799,0.015465264,0.02138268,-0.06415412,0.04175766,0.009879701,-0.04918669,-0.024594782,0.018064998,0.018205352,-0.070355885,0.10778859,-0.027007174,0.013185807,-0.0125416415,-0.069122314,-0.058924485,-0.035084017,0.06961636,-0.032886896,0.088287234,0.112944044,0.00040039816,0.030177396,0.04153794,0.0076510874,-0.010238591,-0.10143501,0.052078187,-0.09033709,0.027338536,-0.0027786219,0.044731125,-0.016913375,-0.04758976,-0.03501176,-0.0020101406,-0.034028623,-0.0070602577,-0.09627087,0.049164534,-0.09376628,-0.008084756,0.019616412,-0.07335896,0.033212766,0.107976824,0.024600228,-0.0008451172,-0.03848119,0.06990585,0.009106132,0.048463833,-0.00048682588,0.067989916,0.034198087,-0.045741234,0.03659403,0.034402464,-0.025061764,-0.035150073,0.065910906,0.016683627,0.030968014,-0.020243246,4.836311e-33,0.011605735,-0.077913694,0.017186211,0.03355449,-0.065626666,0.014890978,0.010207899,0.009723399,0.0025243761,-0.014836456,-0.08799338,-0.09332757,-0.024114909,0.024567388,-0.055074736,0.04193577,-0.024811704,-0.09546465,0.041892026,-0.026784271,-0.025809785,0.089832984,0.056091983,-0.08219253,0.020627027,0.0062325564,-0.026701288,-0.068627015,0.084414475,-0.033457726,-0.029090466,-0.020391682,-0.08346521,0.04874216,-0.048322994,0.03346197,0.045482323,-0.08578186,-0.024617007,-0.035518922,-0.027977597,0.003589184,-0.05169591,-0.11250958,0.07598615,-0.010500797,-0.084245495,0.007906053,-0.008297666,0.07573449,0.08747213,-0.013878525,-0.01685905,-0.014389266,-0.032417644,-0.041679353,-0.005770418,-0.038192518,0.08275064,0.06696916,0.050247267,0.016935507,-0.07234857,0.011375282,0.026709573,-0.04361712,-0.00957163,-0.019695526,-0.032362558,-0.006430482,-0.028425306,0.026903419,0.02133435,0.034869153,0.020502184,-0.062165674,-0.008046068,0.09751458,-0.016801571,0.072082475,0.0972311,-0.027449924,-0.02289037,0.039751865,-0.11290901,-0.024296848,0.05651599,0.0027166805,-0.0633699,-0.07356817,0.0875268,-0.043989334,-0.079307735,0.14635211,-0.05987049,-6.3087415e-33,0.07505824,-0.09670959,0.09275951,-0.007511154,-0.006009902,0.04395623,0.06562759,0.023126675,0.06828285,-0.00083894975,0.08847013,-0.0759925,0.03020812,-0.04133743,0.053264566,0.009462244,-0.009110618,0.08447113,-0.043011878,-0.0035946455,-0.0772077,-0.02093974,-0.04183642,0.088053025,0.08183272,0.007096455,-0.059874468,0.0331117,-0.019882003,0.020656079,-0.057587955,0.023899887,-0.09385024,-0.039284788,0.019352993,-0.059397023,-0.04986011,-0.0027498412,0.031433906,-0.06566107,-0.002777847,0.06599012,0.07471731,0.069601,-0.0012643685,0.106079504,0.013215211,0.010173982,-0.0106094275,-0.07228719,-0.040005747,-0.035350706,-0.0052930578,0.03301831,0.11183765,-0.0070288517,0.06825695,0.0051456043,-0.072282635,-0.019444296,-0.051298082,0.011495119,-0.029748848,0.05522945,0.012999033,0.103721365,-0.03396013,-0.062105976,0.039610766,0.003618653,0.04445283,-0.035252847,0.0855711,-0.0624718,-0.02842605,-0.019746564,-0.07402036,-0.043886077,0.0012237909,-0.04164958,-0.027259449,-0.015919762,-0.022746382,-0.0166221,0.056466386,-0.05016849,0.023298526,0.021251718,0.039047636,-0.004421232,0.013565273,0.016384149,0.08310097,0.0665839,0.08075871,-3.2517352e-08,0.0866683,-0.061821774,0.021381129,-0.10625184,-0.06379539,-0.027966665,-0.003532803,0.03041462,-0.00746823,0.039827168,0.02752744,-0.006949019,-0.032334056,-0.026584068,0.03495071,0.04387265,0.023390165,0.023735974,0.054452322,-0.051912457,-0.067564525,-0.02792095,-0.044566423,-0.0053852354,-0.06656438,-0.04418697,0.0028751937,-0.00020268926,0.016421085,-0.06101141,-0.029092964,0.011911174,-0.04525411,-0.03772377,0.011687331,0.07323115,0.01873899,-0.008663553,0.06306042,-0.03617635,0.01630881,-0.008776057,0.026840487,-0.079596244,-0.008264506,-0.035633694,0.055539604,-0.056767203,-0.014975604,-0.082294375,0.03498333,-0.024746714,-0.07600815,-0.031793404,-0.036501247,0.022636743,-0.034774356,-0.07927605,0.015222328,-0.017795438,-0.024223294,0.0046435506,0.13568117,0.060092185 +3.4.21.77,A peptidase of family S1 (trypsin family) from seminal plasma. Slowly inhibited by alpha1-antichymotrypsin,384,0.99999994,-0.0879926,0.004689028,-0.087834716,-0.055679135,0.039328627,0.09126508,0.00045830457,0.06321726,0.022105336,0.083385244,0.018999524,-0.0057570627,-0.04462982,0.08352245,-0.050897382,-0.06413587,0.035525132,-0.0748823,0.052162137,-0.008456326,-0.013737301,0.029617228,-0.03906545,0.05009233,-0.020628598,-0.025361449,-0.063463815,0.0026374315,-0.02519495,0.025865713,-0.013672085,-0.052054957,0.029646473,-0.016233701,0.028866425,-0.0091470415,0.034547903,0.021726472,0.013989629,0.036124595,0.09663743,-0.022642648,-0.058406137,-0.03576439,-0.018889127,0.00034237138,0.032373473,0.10366616,0.09420136,0.0413387,-0.04675127,-0.06342991,0.06342731,0.005875992,0.08083424,0.01657874,0.000575766,0.0062616826,-0.011332504,0.021477584,-0.07466789,-0.008094858,0.042903863,0.016212557,0.05155885,-0.001273388,-0.048552964,0.051027194,-0.020921417,0.04685973,-0.014629299,-0.011977525,-0.0687396,0.14079484,-0.04994068,0.01520655,-0.049656827,-0.03196059,-0.049804308,-0.08943088,0.00024106415,-0.05659648,0.008824494,0.12766907,-0.022283806,0.01009635,0.040829252,-0.0037072971,-0.0055243815,-0.054482877,0.016141346,-0.14515857,0.12427381,-0.011774926,0.029286396,0.021732226,-0.106232814,-0.103253886,-0.022283345,-0.039475802,-0.015749974,0.008781614,-0.012791569,-0.0585619,-0.057792142,0.055068534,-0.1257761,0.03494748,0.06431518,0.06534422,0.03247425,-0.03841658,0.04012279,-0.017423421,0.021528056,-0.017953284,0.028493524,0.030310208,-0.018327354,0.01784126,0.053960435,-0.0016191407,-0.009551802,0.07122793,0.0068200002,0.011125513,0.035740886,3.021631e-34,0.015495698,-0.077886544,0.024069868,0.057947323,-0.017137514,0.06767379,0.011115941,-0.04597726,0.019241309,-0.040133066,-0.050851956,-0.0752501,-0.030673712,-0.02198558,-0.09597699,-0.014115846,-0.02606569,-0.06452337,0.027124198,0.043963708,-0.046172805,0.109502636,0.0037952084,-0.101139866,0.040688585,0.05018689,-0.08462676,0.005785753,0.02199216,-0.033132583,-0.032673128,0.048004724,-0.10005849,0.00508207,-0.014367885,-0.007865265,0.07029982,-0.09571308,-0.01935557,0.00840058,0.015072762,-0.0019797608,-0.02764291,-0.037087787,0.060110953,-0.01845663,-0.07075842,-0.035686072,0.017188897,0.0033447584,0.04404579,-0.01184007,0.062011942,0.032857426,-0.07984545,-0.024759857,-0.008281955,-0.02349134,0.018437268,0.059154257,0.03925905,-0.0012187479,-0.012078106,0.04540883,-0.04852861,-0.042853076,0.00074930023,-0.045868166,-0.027213369,0.0330229,-0.06401184,0.08892679,0.14049634,-0.059528966,0.03627192,-0.090580754,-0.0033235843,0.10737869,-0.030764315,0.038247544,0.006834343,-0.09526146,-0.02886487,0.027155137,-0.0722972,-0.02272804,0.054313935,0.017083045,0.012316686,-0.06508906,0.014441632,-0.012106579,-0.06295755,0.07381854,-0.029692974,-2.6429012e-33,0.020322898,-0.10840466,0.13855979,0.009444789,-0.034801155,0.07325147,0.07625235,-0.02267353,-0.03188301,0.03985472,0.041039076,-0.07379259,0.04765817,-0.10042973,0.035492454,-0.0015146662,-0.004149856,0.04808807,-0.0048968163,-0.071350135,-0.070865326,0.002997638,0.03671047,0.077645265,0.0646489,-0.017430156,-0.0007003932,0.057166424,-0.032498322,0.004344288,0.00013331803,0.05882071,-0.097576395,-0.066670105,0.026699629,0.046926256,-0.06435331,0.053148326,0.0051076184,-0.11225587,0.018979257,0.07050837,0.05075258,0.037782013,-0.017301947,0.11236761,-0.012867326,0.07894636,0.018611113,-0.025323907,-0.05287957,-0.04974371,-0.020122364,0.042028386,0.07894373,-0.08169014,0.028314477,0.024437696,-0.0058671455,0.02112264,-0.044521563,0.02080565,0.002991575,0.09066178,0.025385266,-0.004097846,-0.036730014,-0.0029334778,0.11579799,0.040844195,0.08123391,-0.029564245,0.12573972,0.0025854807,0.033587195,0.07884145,-0.05953362,-0.09583479,-0.012552517,-0.07381923,-0.0042331805,-0.035537798,-0.05680558,0.045263615,0.011658935,-0.059370957,0.050757315,0.054616455,0.044579443,0.024423113,-0.0049015316,0.03503087,0.017742468,-0.018454919,0.056514636,-2.442549e-08,0.09379023,-0.06724273,0.04043787,-0.05067059,-0.039370503,-0.056474354,-0.037740845,0.008894919,0.064891785,-0.04718689,-0.0075946962,-0.029861199,0.059291538,-0.017446812,0.019486042,-0.003952486,0.022299182,0.034056004,0.0018919975,0.033244118,-0.035529207,-0.039337255,-0.04432314,-0.0408849,-0.051303446,0.024756204,-0.008660514,-0.006941044,0.03407303,-0.09573356,0.019111704,-0.012944642,-0.06208905,0.04172978,0.014488216,0.061944984,-0.025511509,0.025787147,0.02370962,0.0032167535,-0.036072902,-0.09519697,0.0099036,-0.07192356,-0.085936524,-0.009786345,0.028778357,-0.009747048,-0.0056501464,-0.025664339,0.0070009218,0.028999867,-0.05799128,-0.05318053,0.010060744,-0.037256863,-0.025129398,-0.032182544,0.05549941,-0.01239472,0.02032847,0.011197483,0.08542592,0.0851691 +3.4.21.78,From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe!-,384,1.0,-0.05375172,-0.005324912,-0.0390622,-0.07288523,0.024219457,0.060482163,0.03981941,0.14214657,0.061859436,0.07304951,0.027423311,-0.028349608,0.031410895,0.11289722,-0.052084256,-0.029552454,-0.043761224,-0.018931337,-0.0099968705,-0.082496956,0.07671584,0.054983582,0.0028747015,0.025733665,-0.053869445,-0.023376178,-0.010066905,-0.0022355015,-0.0017019714,-0.008079024,-0.082076855,-0.044328444,0.004585449,-0.04200495,0.04545697,-0.016706426,0.0069894013,-0.0078016333,0.06597551,0.0068264343,0.034254238,-0.02838939,-0.065872006,-0.04042741,0.007206343,0.0029006233,0.016687592,0.059492134,0.04650255,0.069140725,-0.01686228,-0.02732987,0.020581849,-0.008732737,-0.00979375,0.070177235,-0.03994769,0.031814955,0.045756895,0.009587,-0.02021323,0.027656827,0.07315709,0.06215866,0.06942924,-0.06570969,-0.022658043,-0.017843684,-0.05503927,-0.033300556,-0.00816128,-0.06646567,-0.051624987,0.13947552,-0.015595788,0.045871567,0.03496683,-0.04546633,-0.08837856,0.0050533675,-0.015275612,-0.04244928,0.041836448,0.082188904,-0.0022561348,0.013274686,0.0126691675,0.07411997,0.020449564,-0.06649431,0.023909947,-0.058653243,0.03188303,0.029193088,0.0020847076,0.029624622,-0.06653868,-0.050923284,-0.0053222217,-0.018877711,-0.026524194,-0.008566619,0.07583283,-0.05707291,0.015143864,0.06195918,-0.06009901,0.0037572733,0.08638475,-0.018958632,0.013275743,-0.022663468,0.08937124,-0.024795363,0.05894901,-0.023934696,0.031391967,-0.016167665,-0.006457469,-0.024632324,0.052400794,-0.034711417,-0.028929101,0.0970989,0.04314412,0.046834007,-0.020124404,4.152709e-33,0.048714478,-0.039704353,0.062072292,0.06438292,-0.060038712,0.009544399,-0.0035041054,-0.050834484,-0.0017447091,-0.03268089,-0.10459778,-0.11329339,-0.0035153602,0.0002111078,-0.10412866,0.0441357,-0.068746544,-0.075029865,0.0037009767,0.037098862,-0.060218506,0.0730684,0.012382425,-0.065112896,0.045982506,0.06703596,-0.040156335,-0.036726434,0.066205904,-0.024801357,-0.039839663,-0.002392068,-0.10721557,0.0247563,-0.068953246,0.037164174,0.045865517,-0.020058904,-0.040778786,0.040937647,0.03934876,-0.004280127,0.015942847,-0.048300948,0.07533508,-0.058193132,-0.09398706,-0.026462054,-0.012304502,0.053571727,0.06753488,-0.081889726,0.024267064,0.016532855,-0.057007656,-0.031661857,-0.009907534,0.01675299,0.043196127,0.09478247,0.09459674,0.013860432,-0.030164631,0.04896756,0.019860428,-0.04729232,-0.03093458,-0.053068917,-0.0572491,0.04179307,-0.032867372,0.021534272,0.07789824,-7.7583056e-05,0.039137743,-0.10232211,0.05565552,0.06214055,-0.00521705,0.064269975,0.060506012,-0.07417973,0.014240647,0.008215842,-0.06199351,-0.046828408,0.045551803,-0.035180964,-0.059150863,-0.05501678,-0.016659252,-0.037162725,-0.09231643,0.11688935,-0.09136784,-5.393806e-33,0.043914273,-0.095743544,0.11084565,-0.034394205,-0.013608453,0.034556273,0.050812345,0.01615021,0.04177832,-0.026712436,0.06629462,-0.11885619,0.009772156,-0.09148286,0.038390163,-0.01347622,0.0017854085,0.060188286,-0.011440673,0.029235423,-0.10105689,-0.042047706,0.0032222557,0.048669398,0.075631924,0.032193728,-0.061930533,0.02584324,-0.006604928,-0.023628676,-0.022331247,0.008653078,-0.07890614,-0.038566325,0.0038094867,0.025912562,-0.055558212,-0.0031318008,0.06210169,-0.09547043,0.046505462,0.033523727,0.07707555,0.05488429,-3.5261106e-05,0.1110196,-0.01346493,-0.038595222,-0.018450826,-0.041325267,0.020793224,-0.038551774,-0.0053281887,0.027531333,0.06277294,0.005249629,0.033991132,0.0206189,-0.0007235868,-0.024485754,-0.012597786,0.0060485853,-0.07415306,0.07413408,0.017138263,0.04555039,-0.09520209,-0.0015026059,0.009206777,0.0059452076,0.050261483,-0.037765864,0.023495685,-0.04609317,0.0042967307,0.014629039,-0.10992881,-0.06270834,0.055465423,-0.05476201,-0.03262284,-8.443511e-05,-0.039599724,-0.008888244,0.07047823,-0.044191115,-0.03858985,0.04882336,0.06786943,-0.017300049,-0.012781216,-0.019135706,0.052470364,0.03829927,0.047493584,-3.421979e-08,0.14128338,-0.060519844,-0.009033079,-0.07505086,-0.06575223,0.012309972,0.0067263525,-0.002543577,0.06187784,0.0073826876,-0.033481006,-0.01318718,-0.05728395,0.0045343097,0.048025407,0.07561381,-0.05500221,0.046330817,0.033848185,-0.027080305,-0.057547107,-0.0077962745,-0.03590234,0.022865914,0.00269164,0.03188177,-0.033808522,0.04196599,-0.008445006,-0.06396367,-0.0015244016,-0.021152727,-0.07518972,-0.0137664415,0.030501882,0.038141318,0.01248189,-0.026064176,0.013355012,0.009776528,-0.005816818,-0.038800485,0.0027396989,-0.08238079,-0.023534777,-0.026084147,-0.008878997,0.013631002,0.007334507,-0.093038216,0.016824184,-0.04586401,-0.112703755,-0.07316102,-0.08771,-0.026841719,0.058682878,-0.06692192,0.03196822,-0.10464093,0.017838133,0.08201469,0.17642511,0.0668884 +3.4.21.79,From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family),384,1.0,-0.050532166,0.009722613,-0.053234372,-0.06862054,0.008403772,0.05436725,0.04411359,0.14649847,0.055721547,0.071077764,0.021702673,-0.021211484,0.058535732,0.08950083,-0.041041363,-0.029080868,-0.0032685795,-0.023037335,-0.0025407511,-0.08362571,0.039614327,0.013985632,-0.0065250574,0.04162284,-0.05749483,-0.02008161,-0.068186775,0.025494238,-0.014447866,0.021669185,-0.087538995,-0.034016434,-0.02091711,-0.03024666,0.036464367,-0.051356867,0.016225876,0.04351296,0.04491389,-0.01398497,0.017934404,-0.028548881,-0.04274135,-0.015055192,-0.0028030185,-0.0026478067,0.03841477,0.11385503,0.073074006,0.052246407,0.005453126,-0.017700084,0.051466208,-0.00421047,0.014389292,0.070801795,-0.039556585,0.010405734,0.047904134,0.009766903,-0.035479445,0.018107591,0.06689975,0.03235401,0.037453685,-0.055662066,-0.022677258,0.014707237,-0.06027631,0.010367031,0.035459246,-0.03075476,-0.055123065,0.14478862,-0.03329409,0.021879485,0.04026106,-0.042624906,-0.084149346,0.002792755,-0.0058371644,-0.023440972,0.062199853,0.077976204,-0.030574039,0.008391242,0.018244587,0.04737157,0.026327431,-0.07203464,0.035800908,-0.07180807,0.08484759,0.03393954,0.045860704,-0.0016325227,-0.039279483,-0.06505711,0.0062066615,-0.023362424,-0.026903076,-0.04272056,0.085148424,-0.03137868,0.018337196,0.06374404,-0.066822454,0.010069644,0.10020948,-0.031642135,0.018101616,-0.027172364,0.0527001,-0.020440504,0.044449646,-0.039371606,0.053102046,0.010493326,-0.020477947,-0.028546173,0.06688163,-0.0057820217,-0.05601402,0.07465134,0.053786553,0.03566624,0.0036066892,2.5340066e-33,0.03732494,-0.040880945,0.019757822,0.08800534,-0.04465281,0.02162354,0.018453991,-0.059527237,0.011085283,0.019856812,-0.14041817,-0.11139601,-0.019210473,-0.0028741595,-0.11281547,0.045841817,-0.08752476,-0.074254334,0.0042941063,0.038099673,-0.089356594,0.099503234,0.024432218,-0.107760414,0.030285731,0.08247708,-0.01886061,-0.058799457,0.0509778,-0.026763627,-0.051958065,0.026719334,-0.09820681,0.03380732,-0.06712548,0.02775884,0.07857326,-0.025617816,-0.007655128,-0.007783769,0.024261627,0.025190232,-0.0033651935,-0.056578442,0.059427723,-0.032759175,-0.06508721,-0.056330103,0.0012018154,0.05325424,0.08312436,-0.078734286,0.016723936,0.025208024,-0.0424518,-0.041185606,-0.023934256,0.027078476,0.070631094,0.07404951,0.09231042,-0.029526219,-0.025507119,0.0340379,0.048736483,-0.054465353,-0.014222796,-0.021345431,-0.044484474,-0.0036855612,-0.0087765185,0.034527224,0.09650244,0.004655096,0.0441154,-0.06296262,0.057408303,0.069080204,-0.023162648,0.083070904,0.06173699,-0.07381212,-0.0014130933,0.011034664,-0.05864185,-0.007812782,0.06399454,-0.014812737,-0.08375004,-0.063207485,-0.015207096,0.011308824,-0.0848865,0.101255365,-0.11145612,-4.1187324e-33,0.023286691,-0.084936045,0.09700544,-0.021794839,-0.012605713,0.018594474,0.04334885,0.021247912,0.05282712,0.008311569,0.057492644,-0.10699363,-0.042616844,-0.0887316,0.014214852,-0.050084673,-0.008364906,0.064965405,-0.048484012,0.011037932,-0.11648025,-0.06345318,-0.034815036,0.025897067,0.07058388,0.02333062,-0.049665634,0.020334363,-0.016230006,-0.031532057,-0.011497179,0.009837884,-0.050249092,-0.038436137,0.055834647,0.015486763,-0.039586328,-0.005703977,0.06470256,-0.11092717,0.04506956,0.02587959,0.075541094,0.056725733,-0.0028425371,0.09984545,-0.011530972,-0.006149093,-0.0022317925,-0.048478886,0.00139142,-0.07302477,0.0017311998,0.0346896,0.093285315,-0.028539546,0.0551072,0.041463986,-0.006192685,0.006858642,-0.006261549,0.031799015,-0.07532581,0.07400526,0.0295629,0.05901204,-0.094567396,-0.0573145,0.024222713,0.03104248,0.007928167,-0.042964384,0.04718895,-0.06911474,0.011651563,-0.010558584,-0.07692075,-0.046938464,0.044592224,-0.042059194,-0.0031948073,-0.013375661,-0.008918364,0.024820667,0.060163356,-0.0448988,-0.02273625,0.049047038,0.08113873,-0.01558299,0.016030744,0.008264821,0.05990163,0.0396683,0.04069799,-2.7299876e-08,0.12791257,-0.069734894,-0.020763116,-0.10158868,-0.083215766,0.033546716,-0.035237364,0.023096101,0.058923885,0.0047479053,0.0018402515,-0.010076368,-0.06441228,-0.040036105,0.004140286,0.037160765,-0.02335709,0.010416121,0.044617224,-0.0060969424,-0.06533373,-0.020431275,0.0016065869,-0.025869297,-0.0041734288,0.0043387893,-0.04469836,0.023129469,0.032327883,-0.0829189,-0.009010418,-0.03429496,-0.10303212,0.00033630908,0.03207032,0.0054618306,-0.017294392,-0.032079287,0.07078199,-0.030617883,-0.021763386,-0.034871355,-0.00065066386,-0.079824746,-0.055395998,-0.053998537,-0.01716219,-0.0059491857,0.0014568492,-0.099382386,0.008598523,-0.015361734,-0.10462275,-0.05164017,-0.060527183,-0.014681714,0.03371798,-0.032127213,0.035907645,-0.07608699,-0.0034228147,0.062774174,0.09898507,0.085852586 +3.4.21.80,"From Streptomyces griseus. A component of Pronase, in family S1 (trypsin family). Not inhibited by Tos-Phe-CH2Cl or ovomucoid",384,1.0,-0.047857463,0.01035179,-0.17538768,-0.03281024,0.04080687,0.04667317,0.037622996,0.09887624,0.0568653,0.021413129,0.023519209,-0.037660155,0.025567437,0.10139943,-0.124479875,-0.042552024,-0.00073325133,-0.053213406,0.08808556,0.008180576,0.042165738,0.10403367,0.029575003,-0.05505728,-0.0051533515,0.008523258,-0.022525826,0.016548917,-0.010459241,-0.028784767,0.01811013,-0.028627241,0.04516809,-0.031975646,0.064300604,0.08887442,0.018231273,-0.0043162177,0.09670633,0.040222585,0.015217625,0.034929108,-0.04065261,0.00423528,-0.014195581,0.07871923,0.03750294,0.09763113,0.032781895,-0.010118323,-0.010167227,-0.113381915,-0.06384495,0.04741073,0.06902253,0.018839039,0.017009106,-0.0045730425,-0.022218864,-0.05911353,0.03009545,-0.07216508,0.06449371,0.017447673,-0.022373844,-0.023931524,0.0129334815,-0.0042009824,-0.03861455,-0.015892608,-0.028725952,0.0008311517,-0.0102590965,0.15242836,-0.04580593,0.06590462,0.02806295,-0.06041653,-0.029776135,-0.10560123,0.06566067,-0.028028764,-0.03493014,0.07601376,-0.009522827,-0.041502107,0.04400412,0.008897392,0.064332195,-0.033993255,0.017950606,-0.08693003,0.034032088,-0.048915055,-0.007797286,0.016407393,-0.12348497,-0.05984782,-0.03135037,-0.03651702,-0.038651966,-0.043575678,0.057657804,-0.045658283,-0.041314226,0.03161195,-0.07555823,0.02905639,0.06885745,-0.011742406,-0.022751065,0.021570733,0.0049215066,-0.03213803,0.004581308,-0.011988872,0.09669625,-0.034463987,-0.037930172,-0.025581952,-0.009529085,0.019129805,0.0080212485,0.011228241,-0.00787101,0.04649037,-0.03295629,1.270914e-33,0.019584093,-0.050470155,0.008200271,-0.03622263,0.036880013,-0.0152881695,-0.033151332,-0.04900431,0.04433785,-0.04533782,-0.1466932,-0.12033781,0.009054143,-0.024116153,0.00864479,0.065115735,-0.03189609,-0.004792818,-0.0007362533,-0.04193686,-0.053184204,0.037620246,0.017280228,-0.07319905,0.07547726,0.024471657,-0.021183677,-0.014070155,0.08587517,-0.077356905,0.040427588,-0.048320692,-0.07602992,0.0586397,0.05333013,0.01703212,0.029151024,-0.07660335,0.017805167,0.0020354285,-0.008951966,-0.008355673,0.017581185,0.034249883,0.049271602,-0.08210701,-0.09267999,0.067082696,0.033251528,0.06846421,0.055911295,-0.06887717,0.03735412,0.014260976,-0.12160623,-0.021133596,-0.0008978104,0.029819014,0.081877865,0.050155208,0.039774157,0.020366408,0.011616561,0.03356731,-0.00032734688,-0.015104837,-0.069398895,-0.025541473,-0.030054852,-0.022331236,-0.07383078,-0.023033798,0.09590407,-0.02916463,-0.05017248,-0.0025777542,-0.00226501,-0.0075275716,0.008525301,0.070418924,-0.018375322,-0.050464094,-0.02810697,-0.009707173,-0.09700065,0.06439724,-0.014313345,-0.072295204,0.0031171525,0.01132328,0.011138084,0.029798413,-0.108654074,0.017445054,0.03866765,-3.130204e-33,0.029885408,-0.07349543,0.08252147,-0.045521926,-0.016490705,0.07523134,-0.02410602,-0.034737792,-0.05435045,-0.0399775,0.04770679,-0.065452814,0.01722849,-0.06503163,0.030552845,-0.02935709,0.0020518433,0.11847212,-0.0046146354,-0.028313449,0.041115098,0.04990637,0.022207588,0.020239113,0.044258703,0.021974871,0.00654895,0.0006501592,-0.029390007,0.056481488,0.036615748,-0.008499658,-0.09135817,-0.060294196,-0.025504798,0.041952126,-0.038502146,-0.0020723778,-5.2637624e-05,-0.077820376,0.057716757,0.055203095,0.070271485,0.11463885,-0.0031578888,0.08410648,-0.014695282,0.04844073,0.0039551323,-0.043642912,-0.007514365,0.017696247,-0.023865096,0.00052530563,0.07487716,-0.03594342,-0.02351398,-0.034819447,-0.025440553,-0.039474364,-0.027032612,-0.058329135,-0.03230489,0.019962827,0.10304832,0.06179306,-0.042376112,0.013808064,0.13157685,0.0073091136,0.032891493,-0.052792635,-0.035568077,-0.0030584857,-0.050300587,0.013895372,-0.07967677,-0.013813149,0.04441413,-0.045986053,-0.020960936,-0.052858263,0.009687798,0.0025292735,0.022679258,-0.09855081,-0.003420998,0.05644425,0.06990935,0.0015572318,-0.06280427,0.048964884,0.040265787,0.023545308,0.012540752,-3.0024662e-08,0.06454774,-0.04061297,0.05512155,-0.014778286,0.009511603,-0.09452272,-0.00028561335,0.03756537,0.06209994,-0.037484575,-0.044734538,0.0016651225,0.008260867,-0.09557271,0.074269846,0.04566774,-0.034358706,0.078848094,-0.009860498,-0.016733129,-0.04825338,-0.03466889,-0.10180984,0.043581933,-0.0134723475,-0.033925567,0.041030075,0.055317488,0.03961424,-0.03498955,0.038941577,-0.016941806,-0.03377742,-0.045917947,0.03382435,0.05695713,-0.010237958,0.038666256,0.014378786,0.011771738,-0.016395234,-0.0025142247,0.004535979,0.01999052,-0.13656786,0.087151766,0.013202568,0.020906484,-0.03136106,-0.04637285,0.020370051,-0.013038082,-0.015496545,0.014059223,-0.13881344,0.009483326,0.022924174,-0.08873481,-0.031087281,-0.016890638,0.009397773,0.03383289,0.15949494,0.075288296 +3.4.21.81,"From Streptomyces griseus. A component of Pronase, in peptidase family S1 (trypsin family), distinct from Streptomyces trypsin",384,1.0,-0.02391323,-0.0044698995,-0.14833252,-0.07878892,0.04810476,0.054691494,0.026738169,0.08985405,0.042713393,0.03989183,0.032020442,-0.05396212,-0.00484546,0.103532225,-0.07006842,-0.071480535,-0.035062134,-0.087428376,0.07130178,-0.03105771,0.02867638,0.09967176,-0.00929045,-0.026524603,-0.03039934,0.01773418,0.026811585,0.0023935505,-0.008084446,-0.008309424,0.017173579,-0.08211055,0.03254642,-0.045554224,0.08735267,0.07805625,0.0015250681,-0.010566467,0.10206962,0.03020706,0.008059962,0.045796867,-0.019340552,-0.0037985602,0.011456669,0.062680416,0.07083271,0.1024906,0.05752109,-0.04936087,-0.0003983614,-0.10989184,-0.039172817,0.012973582,0.096119374,0.01546269,0.039512318,-0.0427293,-0.007600439,-0.027294017,0.01266773,-0.076095186,0.05878753,-0.035476856,-0.03684325,-0.011148815,0.015906379,-0.0065911477,-0.041935496,-0.0011285549,-0.032651804,0.0312972,-0.04599179,0.15081498,-0.059750635,0.057981744,0.0009562619,-0.059557643,-0.066781715,-0.056000262,0.035088416,-0.028200863,-0.0010366013,0.0803381,-0.020116078,-0.051641013,0.059060924,0.016313277,0.041585524,-0.059322324,0.043773767,-0.06534445,0.033565342,-0.018223565,-0.019565381,0.02512256,-0.12923022,-0.07756356,0.013738327,-0.056956127,-0.022564538,-0.056114983,0.08694698,-0.058305286,-0.029948767,0.055718936,-0.07329651,0.06259862,0.08360258,0.016585961,-0.022728145,0.031279005,0.014180041,-0.04204812,0.014936395,-0.01721828,0.07386229,-0.013555884,-0.0295722,-0.011586962,-0.01328178,0.07659277,0.033944037,0.027971888,-0.0073703383,0.050173834,-0.0361095,2.771208e-33,-0.011503157,-0.055617914,0.024154391,-0.026641874,0.053734098,0.0012703021,-0.0451261,-0.029493548,0.06841342,-0.050545976,-0.1337709,-0.10737919,-0.022460395,-0.05886446,-0.02542789,0.062123727,-0.05732089,-0.00035722746,-0.013057241,0.017750835,-0.07202026,0.07017457,0.028434087,-0.11930547,0.0880155,0.031069322,0.01641842,-0.014736421,0.043150917,-0.099546194,-0.008937332,-0.05779784,-0.08625329,0.041005395,0.043199945,-0.0086023845,0.0802642,-0.06064039,0.0014494505,-0.01901107,-0.011905399,-0.000814257,0.021233225,0.029314352,0.061650954,-0.036621753,-0.07537453,0.048987605,0.050365865,0.054414216,0.045569226,-0.06116436,0.048103172,0.013883191,-0.09867513,-0.030074265,0.009031487,0.030954132,0.12760499,0.03760334,0.06965882,0.023612633,0.011950234,0.00943827,0.024168154,-0.00048210885,-0.047490418,0.0037490407,0.012479217,0.020782275,-0.06330136,0.017272215,0.10004755,-0.045140427,-0.04785567,-0.045723286,-0.02768358,0.009025628,-0.0065746405,0.07217672,-0.041055877,-0.046489954,-0.031205263,-0.018666217,-0.09789379,0.06267467,0.0056737936,-0.05768385,0.00936278,0.019124474,-0.0019338934,0.03825738,-0.082428746,0.03833552,0.015678579,-3.691951e-33,0.048968475,-0.08839187,0.07927511,-0.021542655,-0.019648984,0.069680244,0.0028686114,-0.027271511,-0.0448372,-0.0535795,0.02530384,-0.040983662,0.004303992,-0.070606604,0.014477141,-0.010848054,-0.023357973,0.10991425,-0.007236347,-0.03256339,0.023584777,0.05146088,0.00470199,0.014983698,0.05758688,0.019216662,0.028253363,0.020405345,-0.035247725,0.0098810885,0.06181623,-0.023481445,-0.09627858,-0.044573605,-0.050258536,0.0107922265,-0.035504874,0.00926491,0.033446897,-0.069496214,0.044589028,0.084264755,0.066188484,0.1355354,-0.043176003,0.08654727,-0.020566354,0.0025378068,-0.027357943,-0.044449985,-0.023038382,-0.032414574,-0.046519965,0.0025551228,0.037797343,-0.051953215,-0.015567623,0.026623484,-0.00048028206,0.021632647,-0.029544612,-0.05003067,0.00475959,0.046272133,0.088970646,0.022634188,-0.056387465,-0.042175364,0.13113818,0.053084183,0.014469792,-0.03442971,-0.01621387,0.010341244,-0.020917779,0.0705271,-0.061881956,-0.02603207,0.02913969,-0.028519014,0.0025484078,-0.06418063,-0.013731097,0.015022778,-0.008066287,-0.05989659,-0.0016049478,0.046968047,0.068441026,0.005922304,-0.03913464,0.052481208,0.05964498,0.03193197,0.010039382,-2.5549868e-08,0.030092414,-0.021164808,0.041084103,-0.008776984,0.0010013068,-0.10183721,-0.00342463,0.011977785,0.05688393,-0.048299495,-0.04077988,-0.02996517,-0.040474292,-0.04125834,0.019776797,0.043457687,-0.060773056,0.06360265,0.032586183,0.019091783,-0.061714634,-0.00049076026,-0.12635161,0.034948155,-0.009753177,-0.03281509,0.024715634,0.07417398,0.027024392,-0.021146873,0.037794836,-0.026234189,-0.022510476,-0.029700447,0.062277317,0.05394538,-0.034904342,0.040163547,0.017917844,-0.031113567,0.0014258361,-0.07422082,-0.017968746,-0.043980934,-0.15168753,0.06591419,-0.0047658696,0.024001213,-0.02289762,-0.032734953,0.06831556,-0.0073102303,-0.0051456103,0.0124410475,-0.09909504,0.031283613,0.010837602,-0.059553344,-0.03971248,-0.01423857,0.027406929,0.017726935,0.14023946,0.08277883 +3.4.21.82,From Streptomyces griseus. A peptidase of family S1 (trypsin family). Inhibited by [Leu18->Glu]-modified turkey ovomucoid third domain,384,0.99999994,-0.02147084,-0.0063899024,-0.14316581,-0.0607898,-0.0052172216,0.028857926,-0.0416792,0.05437431,0.101631954,-0.020609505,0.01013165,-0.005824545,0.013455074,0.09035282,-0.06369741,-0.034458667,0.030136526,-0.014995681,0.055164747,-0.05128878,0.0361978,0.063891314,0.023622997,-0.03836789,-0.033057507,0.011250118,-0.04610853,0.011258314,-0.027613696,-0.0021777821,0.038782317,-0.053318348,0.022982694,-0.041262794,0.0788242,-0.00020622349,0.031721342,0.003544578,0.11523949,0.008216574,-0.008467212,-0.03539675,-0.01897785,0.003913822,0.0033205717,0.03022767,0.0011319479,0.11998468,0.07941575,-0.033053886,0.007745028,-0.07681983,-0.029044256,0.03670262,0.071530305,0.04033189,-0.022976354,0.017136626,0.022155466,-0.042529523,-0.0012026121,-0.02647221,0.0773126,-0.021888543,-0.08361593,-0.05385523,-0.007978733,-0.03508808,-0.01914447,0.05314824,0.019943727,-0.021607822,-0.06395107,0.094544634,-0.020730356,0.045526583,0.012309981,-0.037585177,0.006384461,-0.058748774,0.08682781,-0.028139843,0.07751837,0.07437377,-0.020428183,-0.05022042,0.04968363,-0.0045112576,0.05422312,-0.05366566,0.07937825,-0.13509996,0.065548256,-0.037744436,0.093929365,-0.005850282,-0.119330674,-0.072177775,-0.027550219,-0.007911937,-0.021536341,-0.05389523,0.07488074,0.0046054143,0.0032436769,0.11324385,-0.066422,0.071391925,0.1245908,-0.059815478,-0.035253685,0.01590417,0.0058781034,-0.054351278,-0.00021719681,-0.0029658885,0.07035761,-0.02184785,-0.06192126,-0.037215173,0.04605271,0.011913355,-0.004009315,0.04995217,0.02464522,0.0785603,-0.05042878,1.6461245e-33,0.020328734,-0.06485027,0.03292949,-0.06469664,-0.0012199072,-0.013837907,-0.05052742,0.0042402586,-0.0016342669,-0.0096076615,-0.1144726,-0.107595526,-0.03352919,0.050285272,0.04395802,0.072213076,-0.01039018,0.010938574,0.04669253,-0.007887899,-0.06391911,0.05705819,0.05483544,-0.072295465,0.07493462,0.06001328,-0.010381299,-0.024691353,0.097831026,-0.050209988,0.005327922,-0.02774283,-0.10142592,0.030884212,-0.029735208,0.002980594,0.054594744,-0.07212099,0.024706488,-0.02465289,-0.013255849,0.047217607,-0.0047092577,0.0066184057,0.06524093,-0.042105354,-0.01114488,0.0137409605,0.021979557,0.09167157,0.0322153,-0.042969167,-0.005270729,0.066410154,-0.07747821,-0.018895483,-0.01782514,0.04056307,0.12837386,-0.0046839826,0.02820632,-0.009648535,0.040519215,0.03631234,0.04009271,-0.01374697,-0.0134796705,0.01650872,-0.02262406,0.067318246,-0.04737328,0.029159006,0.0022932647,-0.03452477,-0.014131068,-0.06894855,0.0455702,0.019796984,0.048598588,0.062774755,0.040433858,-0.008629601,-0.015643245,-0.014053876,-0.11245933,0.055954598,-0.008427968,-0.02640596,-0.03603043,-0.001604761,-0.054224737,0.025701674,-0.08075775,0.09628866,-0.017348642,-2.3141645e-33,0.06630427,-0.11883868,0.07096697,-0.019680876,-0.065023065,0.049147602,-0.031446572,-0.04520265,-0.006640696,-0.010405499,0.03583411,-0.07369343,0.0012143513,-0.07892529,0.05011098,-0.049916133,-0.060449332,0.07758046,-0.051018048,-0.0046808855,-0.016035896,0.016671054,-0.01435606,0.036874518,0.031989686,-0.0034355882,-0.011565798,-0.03628062,-0.037695996,-0.012288566,0.011127929,-0.018092602,-0.0921546,-0.014556679,0.051934134,0.033952698,-0.020639941,0.04495475,0.036416233,-0.062956356,0.063726634,0.10908271,0.048952393,0.108013965,-0.0011647108,0.07621376,-0.05475457,0.08733717,0.007916709,-0.052346747,-0.034801796,-0.050309602,-0.02445763,-0.020339217,0.108340696,-0.06460537,0.061548073,-0.024213718,-0.06405495,-0.03935863,-0.046451915,-0.0060500554,-0.012234101,-0.006539107,0.102281675,0.106427625,-0.037791405,0.022935282,0.112609476,0.031643815,-0.0008946786,-0.08556939,-0.020237517,-0.014612925,0.021945773,0.008564671,-0.059361678,-0.038978852,0.04037254,-0.001731557,0.031227913,-0.08847645,0.028076228,0.01984585,-0.0053899935,-0.043609034,0.032708906,0.06491915,0.07784153,0.05446104,-0.023585252,0.0023403547,0.0844055,0.025570337,-0.001059367,-2.940614e-08,0.059862375,-0.025785575,0.04260335,-0.00953832,-0.049925733,-0.09421131,-0.053663496,-0.02596049,-0.012219407,-0.017316803,-0.03350656,-0.012614052,-0.019675575,-0.065122955,0.007224714,-0.003116505,-0.03676131,0.050083358,0.054136533,0.025625352,-0.10691693,-0.003722031,-0.025977215,-0.03213013,-0.003528852,-0.10903606,0.050219916,0.022622833,0.0050737215,0.0037386946,0.005129119,0.01615739,-0.07494706,-0.009778429,0.051811222,-0.044832505,-0.037973937,0.0018855248,0.04351319,-0.027172204,0.014411136,-0.016272228,0.025984777,-0.07181405,-0.1334711,0.015242797,0.058165643,-0.055035334,-0.022131093,-0.025917577,0.0042515933,0.004086779,0.0039205463,0.0077965828,-0.092356585,-0.0015033326,-0.012088637,-0.087497346,0.041968618,-0.074868865,0.0063504847,0.006878772,0.124741726,0.0709431 +3.4.21.83,Known from Escherichia coli. Inhibited by Tos-Lys-CH2Cl. In peptidase family S9 (prolyl oligopeptidase family),384,1.0,-0.10658441,-0.066385694,-0.12253087,0.03569056,0.14350411,0.08154698,-0.02750882,0.12133576,0.043146215,0.018588763,0.025803106,0.03384307,0.010191233,0.097620174,-0.04419056,0.01831092,-0.022347258,-0.038628902,-0.0038518712,-0.05812302,0.061069924,0.071487375,0.009407064,0.03353915,-0.036892116,-0.053173773,-0.018676119,-0.0425412,-0.005825811,-0.061342727,-0.015553485,-0.056017123,0.07773752,-0.057750136,0.095113784,-0.007230126,0.051736668,-0.0406553,0.08084205,-0.0070964033,0.031247756,0.021617351,-0.03934,-0.042098094,-0.0070528956,0.024005845,0.0042610904,0.064360924,0.03744986,-0.0047250083,-0.027967928,-0.04998301,-0.031581994,-0.030779308,0.01550704,0.013091646,-0.013937099,-0.051331304,0.023034325,-0.019982895,0.040218383,0.012024298,0.046053402,0.057339665,-0.053595517,-0.02072629,0.004428429,0.008161351,0.01052872,-0.0017689746,-0.0037565313,-0.042144477,-0.03075843,0.12521486,0.05253492,0.0099793915,0.03264418,-0.04520727,-0.069874294,-0.065273985,0.025730241,-0.057964083,0.055285286,0.056529645,0.009526166,-0.006345735,0.037590478,0.030435454,0.03863583,-0.0494654,-0.00938497,-0.11906402,0.098816514,-0.02551544,-0.0639909,-0.035578832,0.015585472,-0.130828,-0.028035516,0.010354808,-0.0044777705,0.0012912102,-0.045465294,-0.041608788,-0.0064340904,0.04582286,-0.0011035027,0.06292823,0.01894683,-0.019901175,0.077956825,0.00908352,0.053576298,-0.04896995,-0.0072177234,-0.022029754,0.04878794,-0.03229049,0.017847992,0.00050185714,0.08206543,-0.03493005,0.010112778,0.03054622,-0.054643333,0.07986072,-0.0628789,2.8005056e-33,0.004740863,0.012728622,0.04504452,0.0040960563,0.027240898,-0.023353005,-0.008597452,-0.021877652,0.002831478,-0.016181584,-0.091124445,-0.1124597,0.0039192145,-0.0005171392,-0.020857321,0.044594057,-0.05967902,0.0015910622,0.0018316413,0.03174382,-0.041001122,0.030705115,0.028590059,-0.015135177,0.10453082,0.028850257,0.0041628373,-0.0063153044,0.11809567,0.015818752,-0.014662831,-0.02750939,-0.09570718,0.03655883,0.03402214,0.007906992,0.004130449,-0.1071594,0.047123857,0.06512839,-0.020736638,0.022018898,-0.0560575,-0.06101856,0.08002738,-0.026422331,-0.0728387,0.061005227,-0.03589194,0.0345862,0.0129820835,-0.052232087,0.021813838,-0.008151886,-0.061312824,-0.02824923,0.020928578,-0.014250151,0.04647723,0.09936499,0.047576502,0.049841233,-0.044056214,0.0064601297,-0.013994013,-0.025663832,-0.033028804,-0.056253593,-0.052384123,-0.012312233,-0.07298229,0.019573025,0.08666757,0.031349435,4.5997705e-05,-0.097053416,-0.02703052,0.021503605,0.035146296,0.065721735,0.048082672,-0.004146158,0.012406329,0.032161113,-0.019265054,-0.03378984,-0.032137495,-0.029817075,-0.11025243,0.03574618,0.043376278,-0.013632645,-0.0075781676,0.060266566,-0.09254319,-4.3219823e-33,0.026746461,-0.042974904,0.048311505,-0.048760198,-0.072485074,0.0076844627,-0.0376438,0.012928452,0.05398324,-0.05260932,0.0796514,-0.05600851,0.061209314,-0.07608216,0.052138392,-0.0039522094,-0.009292643,0.048808437,-0.049359716,-0.0044058976,-0.0027392665,-0.06263353,0.05210251,0.004538537,0.04835199,0.025447235,-0.045671962,0.09115027,8.179999e-05,0.03771599,-0.030554743,0.035020668,-0.03847995,-0.11749899,-0.059498686,0.039352737,-0.09202755,0.012394291,-0.0039409525,-0.08531833,0.02887542,0.062345617,0.03181817,0.044493306,-0.0077670733,0.03859099,-0.037472393,0.02279156,0.06436401,-0.07429996,0.006973589,-0.090372644,0.010472079,0.019000618,0.048243426,-0.046833936,-0.021885281,0.043573294,-0.037622403,0.0232196,0.00065008196,0.012410092,-0.030367866,0.106436685,0.07415193,0.036256757,-0.10994983,0.014810206,0.09881532,-0.054292068,0.05328253,-0.020608572,0.013895611,-0.0030973256,-0.033984207,0.04104934,-0.14070368,-0.069385454,0.02581124,-0.02555591,-0.0367712,-0.036907498,0.018293256,-0.007572476,0.026815878,-0.08853847,0.008573386,0.11554972,0.08108059,0.036083434,-0.04807694,0.011143442,0.035764907,0.014139885,0.07396935,-2.8811126e-08,0.09472629,-0.11245218,0.045994252,-0.07129403,-0.06856737,-0.004071875,-0.0015500912,0.002811306,0.0154049955,-0.039293047,-0.0012501372,0.057522647,0.011816876,-0.047526233,0.041871227,0.101015426,-0.018416047,0.08213737,0.0042319903,0.016828878,-0.06575544,-0.021642534,-0.03220813,-0.013694875,-0.026389081,-0.0522859,0.013903389,0.012829032,0.055291157,-0.05542808,-0.026818633,-0.054512437,-0.074289046,-0.02123333,0.009711148,-0.0012545409,-0.046038855,-0.027054798,0.010245036,0.00749388,0.0045549623,0.06443312,-0.09009995,0.0053173197,0.014851045,0.028112244,0.018021502,0.05321306,-0.06212504,-0.07648727,-0.020152358,-0.036373332,-0.04265034,-0.01975597,-0.109439254,0.009106264,-0.01565242,-0.056274403,-0.031309586,-0.074842356,0.005258961,0.061201442,0.19366181,0.08339715 +3.4.21.84,From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. Factor C is activated by Gram-negative bacterial lipopolysaccharides and chymotrypsin. Inhibited by antithrombin III. In peptidase family S1 (trypsin family),384,1.0,-0.050995305,-0.010273182,-0.04149429,-0.05344395,0.009121844,0.10910851,0.014008275,0.10924659,0.02317406,0.03865908,0.05001419,-0.1102796,0.023248607,0.05451624,-0.09996411,-0.0033341637,0.04414654,0.048547745,-0.012201813,-0.05007616,-0.028951332,0.026050719,-0.026381874,-0.016224362,-0.09155448,-0.027382744,-0.032431256,-0.02179931,-0.015434043,0.003973122,-0.119084954,0.0082231285,0.05406908,-0.07657225,0.0115336375,0.014102473,0.019073693,-0.07274132,0.01804693,0.107448004,0.030211637,0.0070370543,-0.04472453,0.036546357,-0.024081025,0.023399461,0.05897135,0.09220832,0.046139028,0.04700182,0.011640123,0.015947398,-0.064668365,0.046083443,0.008270889,-0.017776407,-0.069284685,-0.023902431,0.024351727,-0.07852852,-0.07571537,0.081758305,0.066663586,0.026151761,0.036742724,-0.03372879,-0.018500729,-0.0060032983,-0.034536898,0.026657483,-0.017851045,-0.017626444,-0.02646029,0.054495502,-0.016046364,0.052498013,-0.019066894,-0.05331209,0.0199358,-0.0819441,-0.04490303,-0.041162074,0.026938362,0.12488405,-0.0182815,0.045476824,-0.013018902,-0.027159749,-0.06035495,0.0010446651,0.09284635,-0.07209648,0.067393854,-0.07559539,0.007524813,-0.009014683,-0.01904207,-0.03395577,0.006117032,-0.026677521,-0.020217868,-0.01787563,0.058314316,-0.09971862,9.9155106e-05,-0.0022457074,-0.08905138,0.036107086,0.112875,0.0497882,-0.021128215,-0.04259776,0.0793374,-0.048426513,0.01510364,0.019846689,0.05985639,-0.031061992,-0.021624522,-0.052251678,0.039088573,-0.03424564,-0.029548597,0.011090658,0.029467558,0.041211117,-0.08017629,3.7674315e-33,0.07134125,-0.11574101,0.058652025,-0.0062852264,-0.015745,0.0020970623,-0.07700849,-0.055915,-0.052546185,0.06290458,-0.07434687,-0.058036227,0.008294422,0.03385829,-0.043191236,0.03166989,-0.07591544,-0.090740204,0.06430239,-0.015107188,-0.022122702,0.083080545,0.027242515,-0.094900556,0.051919956,0.012166504,-0.023896227,-0.022340542,0.07728561,0.0014039814,-0.06431951,-0.02247253,-0.10330928,-0.018318353,-0.0017463615,-0.0084227,0.078185886,-0.08143729,-0.023524942,-0.046879247,0.09028575,-0.024560634,-0.018316455,-0.06243964,0.06322775,-0.081670545,-0.031864233,0.063628145,0.014545736,0.0022703835,0.1360524,-0.04689387,0.11699836,0.011790778,-0.012559974,0.020378444,-0.04171202,-0.0070986445,-0.01636208,0.08172506,0.039687824,0.011077867,-0.020186212,0.045443278,0.07858327,-0.011675486,-0.05739147,-0.029629892,0.013471051,-0.048553597,-0.0026293278,-0.034922164,0.04683151,0.0036848476,-0.06483265,-0.012006962,-0.012952405,0.056961656,-0.0070053097,-0.025869561,-0.009440246,-0.044276625,0.04027271,0.009189334,-0.016644195,0.010787232,0.08616721,-0.0063967463,-0.05714271,-0.078016676,0.076159954,-0.020074954,-0.07051224,0.057440653,-0.05390207,-4.8730596e-33,0.021397907,-0.12249153,0.036883708,-0.0125857815,0.015406629,0.020976322,0.023624925,-0.04089745,0.0071432954,-0.059832454,0.047860615,-0.0021348977,-0.024474382,-0.02058838,0.08421932,3.51959e-05,0.003372313,0.072168015,-0.09810472,-0.054287594,-0.06947845,-0.121450275,0.043067012,0.08195083,0.022766698,0.031585857,-0.045788955,0.044489294,-0.07615305,0.024856394,-0.045297656,0.02382959,-0.093251295,-0.10275989,-0.01576475,-0.026378162,-0.04405918,0.02478449,0.04216262,-0.06217515,0.06917585,-0.005307848,0.04899553,0.037684042,0.032092936,0.10646986,-0.019114884,-0.0041694683,-0.044261083,0.004604521,-0.023759522,-0.061216533,0.09810586,0.052466385,0.08254524,0.071530946,0.035319723,0.03208593,0.049180936,-0.04312801,0.0036962484,0.013372087,-0.0037879173,0.033189986,0.1088416,0.06761672,0.015000692,-0.018338323,0.06617351,-0.03625893,0.05587438,0.07303934,0.07399188,-0.023737743,0.016639395,-0.0012659369,0.0046529216,-0.025833273,0.06539548,0.0017903037,-0.03531304,0.023766542,-0.028585557,-0.00033414617,-0.034543097,0.003531286,-0.049116377,0.0773822,0.061339956,-0.0041971887,-0.02010145,-0.01793566,-0.026960017,0.009821041,0.066450596,-3.695652e-08,0.066201605,0.006632366,-0.022693707,-0.077926785,-0.03769698,0.0075531355,-0.036815595,0.0537479,-0.006379807,0.006861481,0.07928983,0.03215147,-0.016631974,-0.025371466,0.073958956,0.044332303,0.06431228,-0.025951734,-0.02742124,-0.092420846,-0.055588868,0.017228946,-0.004766972,0.06692475,-0.024976673,-0.06410838,-0.0035915705,0.0269051,0.029260337,-0.010378129,-0.025276005,-0.015073058,-0.10421194,-0.08155698,0.004718823,0.040594198,-0.01130803,-0.015818784,0.07883404,0.008410512,0.024900546,-0.010080007,-0.055413343,-0.06290178,-0.040876314,-0.0037876666,0.030671624,0.12679969,-0.011885204,-0.038950574,-0.020869585,0.062636286,-0.0573357,-0.04996547,-0.101491384,0.01175568,0.02001679,-0.012716236,0.026546124,0.007012868,-0.019052373,0.0063664913,0.12011909,0.069644585 +3.4.21.85,From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. Factor B is activated by limulus clotting factor _overbar_C_. In peptidase family S1 (trypsin family),384,0.99999994,-0.024923343,0.00034753943,-0.041286856,-0.05623843,0.026360825,0.08256606,0.0362755,0.107730195,0.02039605,0.0127981445,0.07122082,-0.11468997,0.031334072,0.046161465,-0.08176454,0.032795746,-0.015537676,0.027432755,-0.03530376,-0.061221227,0.002732548,0.044574425,-0.019537967,-0.011416618,-0.07473159,-0.009293691,-0.01480097,-0.032603834,0.036266632,-0.027764272,-0.08993296,0.027193328,0.042122815,-0.07140982,0.018091686,0.0051977756,0.02366032,-0.061976653,-0.039570186,0.09945574,0.05377787,0.0015601177,-0.027618047,0.017193994,-0.0063307188,0.04406443,0.022268912,0.08898431,-0.000781414,0.04972532,-0.0004941389,-0.030663382,-0.053524822,0.051094454,0.024486352,-0.031183658,-0.09191334,-0.005563062,0.039934665,-0.07814569,-0.08940567,0.07722265,0.023367638,0.00096920895,0.070633605,-0.0074211867,-0.0069742934,0.0052927826,-0.06761977,0.041813254,0.03244292,0.0044655334,-0.06405497,0.03378234,-0.009935063,0.023668936,-0.057921644,-0.020625208,-0.020219909,-0.04087281,-0.077320315,-0.037868693,0.044504233,0.081981994,-0.025696088,0.07793958,-0.0085529145,-0.0009267857,-0.08126023,-0.0110780345,0.11714143,-0.049017224,0.06337052,-0.053839363,0.034542553,0.020984469,-0.026792137,-0.036880203,0.031010663,-0.025436826,-0.034997027,-0.038581666,0.045158833,-0.03371995,-0.031047877,-0.0012220403,-0.07655103,0.063382246,0.17423765,0.031098155,0.00048341966,-0.056296773,0.1143184,0.0013154,0.04566656,0.0056282002,0.002667169,-0.028671999,0.014049159,-0.0363017,0.07505211,-0.0017798103,-0.07582071,-0.012836951,0.0033726313,0.06659771,-0.09118408,3.984993e-33,0.0883023,-0.087663844,0.044782437,0.016721414,-0.048491243,0.008303666,-0.08847285,-0.046197176,-0.06501959,0.06356147,-0.110582225,0.004101972,-0.016295727,0.0087841,-0.06328083,-0.024527177,-0.05256124,-0.08258093,0.04593365,-0.010811605,-0.008057585,0.11206397,-0.024783418,-0.07734488,-0.0047673713,0.0034449247,0.017885406,-0.037509374,0.0473675,0.008327147,-0.046758775,-0.030503834,-0.08748409,0.0008956927,-0.05316759,-0.005828569,0.07887055,-0.08259988,-0.05374006,-0.025257623,0.103451625,-0.05529403,-0.038383223,-0.0018138835,0.08402441,-0.07247973,0.00028789553,0.036907062,0.026311189,0.014638454,0.09021956,-0.022742908,0.0879808,-0.02079515,-0.0379412,0.04587108,-0.031834442,0.009774828,-0.04483021,0.10252033,0.069241166,0.0088276435,0.009361377,0.036799394,0.07657333,0.011570145,-0.06612642,-0.043881733,0.015749468,-0.040737513,-0.018914653,-0.015198571,0.032852836,0.0004964238,-0.08537735,-0.0021356847,0.011612297,0.046206888,-0.04447598,-0.01818497,-0.03613307,-0.056905735,0.022663878,0.021677822,-0.044627808,0.0025849654,0.13204871,-0.038473573,-0.09731839,-0.08482238,0.0520682,-0.033113018,-0.059234425,0.020515257,-0.034826946,-3.6499845e-33,0.014006912,-0.11435633,0.04664937,-0.0012710125,0.013294267,-0.0040292195,0.07807627,-0.05622262,-0.0008562589,-0.06264486,0.0025719374,-0.015367186,-0.008356315,-0.0407458,0.04569676,-0.002823735,0.02051966,0.0705206,-0.06249412,-0.058256283,-0.11221192,-0.08076122,0.0587111,0.06121795,0.043953806,0.051653523,-0.008487502,0.017513346,-0.049652226,0.009911712,-0.057211846,0.014779254,-0.07048336,-0.086412884,-0.051566128,-0.010055842,-0.021184785,-0.0127013,0.048760224,-0.07117867,0.039318785,0.00060598523,0.06149269,0.044293612,0.06059716,0.09940577,0.002005191,-0.0050653378,-0.046041515,0.0012546805,-0.010388438,-0.023031577,0.07722909,0.059411634,0.069267474,0.031667326,0.032268476,0.00067962625,-0.0022186767,-0.052677132,0.020983266,0.027537316,-0.003499383,0.06286652,0.106655836,0.054661535,0.0050627384,-0.0224802,0.036617845,0.0011974936,0.04632142,0.058244508,0.08086124,-0.009756515,0.029586716,-0.0128400605,-0.045667805,-0.030233461,0.027303865,-0.030373061,-0.099586464,0.04867899,-0.022038661,-0.0024974262,-0.032038428,-0.022870818,-0.00068064133,0.093749106,0.08595182,-0.0031122814,-0.03997542,-0.012125608,-0.024936274,0.03985708,0.04422237,-3.3910784e-08,0.057115067,-0.0012890449,-0.0399223,-0.069339305,0.015006036,0.03699461,-0.021374408,0.029891795,0.0042717145,0.0196399,0.01674553,-0.011246571,-0.011096576,-0.03760347,0.10169147,0.07394944,0.06322076,-0.015644666,-0.01916302,-0.10812568,-0.029432535,0.01487,0.02084249,0.062395547,-0.04244968,-0.05069706,-0.03798884,0.05239372,0.077506,-0.013323207,0.006498914,-0.017979965,-0.06535336,-0.12915286,0.03041921,0.08254229,0.0012483303,0.02912355,0.058533132,0.016462915,0.01199552,-0.074058905,-0.014462879,-0.057137154,-0.039900884,-0.02112828,-4.6360947e-05,0.104566924,0.02117394,-0.048635125,0.013599924,0.01098726,-0.03976619,-0.013113567,-0.10788276,0.0046142368,0.0466489,-0.016718132,0.03689418,0.008819665,-0.008786012,0.07359648,0.112127915,0.08492451 +3.4.21.86,From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family),384,1.0,-0.04452618,-0.03916114,-0.07528639,-0.0840703,0.04525241,0.04325121,0.006579027,0.1329563,0.033088375,0.01971368,0.0671902,-0.09421384,0.017815595,0.07181534,-0.08626873,-0.014137311,-0.016723514,0.026124068,0.02635676,-0.09986079,0.032306727,0.02467509,-0.03732402,0.02061427,-0.06423426,-0.03034175,0.009671803,-0.029825136,-0.0026381337,-0.0019011658,-0.08539163,-0.027438166,0.031460024,-0.075722046,0.05831933,0.034615412,-0.0141203515,-0.051406126,-0.0543058,0.09787184,0.079528846,-0.0025265163,-0.050328862,-0.03505465,-0.023358861,-0.005400433,0.022860454,0.05148163,0.013251638,0.0803419,0.0045662676,-0.042005807,-0.045518685,0.015168009,-0.00842563,-0.04077939,-0.07216474,-0.015319826,0.052497648,-0.06759805,-0.06896344,0.06419918,0.017953884,0.03219165,0.053061392,-0.04578685,-0.015467691,0.035424106,-0.095523186,0.050691348,0.03975817,0.015654594,-0.047133785,0.07176234,-0.028279547,0.02700387,-0.050796226,-0.03185099,-0.017719265,-0.039217323,-0.06827429,-0.020795764,0.035283305,0.05491173,-0.032092772,0.13265371,0.010229213,0.015847841,-0.07191816,-0.033394914,0.09659434,-0.025006162,0.023137057,-0.043317005,0.029076032,0.05137866,-0.07988372,-0.037695248,0.04531974,-0.030537963,-0.013007176,-0.02344997,0.078605406,-0.08749603,0.00073918945,0.023900189,-0.069097646,0.083324194,0.12695986,0.058912486,-0.01262813,-0.035528768,0.1318744,0.019736363,0.050789658,0.047113772,-0.047266196,-0.021210443,-0.021951692,0.037411835,0.0495488,-0.010667974,-0.071363054,0.00522883,0.04109168,0.075080656,-0.093529925,4.704926e-33,0.08768277,-0.10130741,0.02743093,-0.009951172,-0.02597743,0.020883726,-0.08037097,-0.03304006,-0.05849473,0.05476089,-0.083060704,0.003756994,-0.0039219414,0.009443544,-0.044355366,-0.04697254,-0.017042156,-0.0633985,0.031462055,0.008726936,-0.0107042305,0.05053192,-0.005613285,-0.028155956,-0.008332164,0.04811809,-0.036355983,-0.02997561,0.053880088,0.011103727,-0.049879044,-0.054587696,-0.06989186,0.02237719,-0.035993256,-0.00028583567,0.0785829,-0.08745868,-0.06603819,0.005608555,0.10062316,-0.06294979,-0.025738383,0.009447646,0.0738468,-0.063622415,-0.02846078,0.0868593,-0.0035805276,0.0060647777,0.12183874,-0.0107397055,0.07616042,-0.031256504,-0.030856946,0.06902097,-0.054881025,-0.0050385036,-0.02008934,0.06861013,0.043620344,0.024981169,-0.030088823,0.038049567,0.09253532,0.025996376,-0.06209107,-0.023545688,0.029989237,-0.019358525,-0.022964898,0.002624455,0.010207062,0.021720892,-0.07990475,-0.007579185,0.030918993,0.043565348,-0.024856836,-0.014148158,-0.02439832,-0.033382982,0.00094692176,0.01184492,-0.014127049,-0.008167231,0.11741926,-0.01888981,-0.075732164,-0.04362288,0.10057192,-0.034559686,-0.095487,0.025305826,-0.046334337,-4.2029558e-33,0.0413409,-0.102103196,0.05469012,-0.020945152,0.023637993,0.031268824,0.045903906,-0.04605996,-0.0313264,-0.09222794,0.0009698396,-0.032564737,-0.01165449,-0.03034129,0.01688681,-0.009343747,0.016245242,0.055106826,-0.03607619,-0.06308425,-0.09531086,-0.04725014,0.07329234,0.04349102,0.0606114,0.025290735,-0.029557688,0.024012119,-0.072221965,0.02964906,-0.038685214,0.02322934,-0.08632573,-0.090337895,-0.05079792,0.014714533,-0.029780878,0.017802501,0.088656984,-0.059279792,0.013947924,-0.029715456,0.061780915,0.036455736,0.02032084,0.10502917,-0.006309675,-0.004507455,-0.056478072,-0.016159395,-0.020353222,-0.01422438,0.05700658,0.054437757,0.07540482,0.033660844,0.018555438,-0.009682043,-0.011003784,-0.05265833,0.00627815,0.017079892,-0.009399651,0.07090092,0.09197914,0.04094809,0.018911934,-0.038141992,0.0149283055,0.034291733,0.08193181,0.04304953,0.068022504,-0.028868457,0.017678663,-0.028942319,-0.05836595,-0.033187397,0.026594445,-0.04815342,-0.08908606,0.0643282,-0.026435832,-0.028534673,-0.024182035,-0.038689625,-0.0049473858,0.07233708,0.06888674,0.031972412,-0.033823635,-0.016983585,0.0060325186,0.03436281,0.053591426,-3.114595e-08,0.03757053,0.002292276,-0.005093591,-0.037497357,0.004336447,0.016986715,0.0040156567,0.0125695495,0.0064848466,0.008892708,0.015368147,-0.0053778216,0.013285128,-0.043532517,0.104147,0.07748068,0.10886549,0.01390319,-0.029630892,-0.0978075,-0.055682164,0.030880362,-0.041163985,0.06291957,-0.058736518,-0.07698136,-0.013605393,0.042779483,0.027014066,0.006835707,-0.050250728,0.014173133,-0.055380467,-0.12640959,0.031801853,0.071264915,-0.0061781094,0.045090556,0.05639718,0.013855788,0.032961227,-0.072007336,0.0016187169,-0.08324827,-0.066709615,-0.010159274,0.03684301,0.08523113,0.04335892,-0.046029456,-0.025607085,0.021254266,-0.028858371,-0.03158162,-0.07242848,0.031165209,0.058033463,-0.0390778,-0.0051110336,0.033082865,-0.048405558,0.04391162,0.16705334,0.030773738 +3.4.21.87,"A product of the ompT gene of Escherichia coli, and associated with the outer membrane. Type example of peptidase family A26",384,0.99999994,-0.06834046,-0.07047568,-0.08836867,-0.053064104,0.042378508,0.045806166,0.046881024,0.10138716,0.11781297,-0.022452075,0.07697295,-0.017171776,-0.066395864,0.029194135,0.006834046,0.028566537,-0.07609344,-0.018606044,-0.037909955,-0.092573084,0.055376463,0.09933628,0.011386906,-0.007240284,-0.088444814,-0.00087303575,0.048543826,-0.030258328,0.031167248,-0.051595815,-0.025538566,-0.095791735,0.074065305,-0.040013894,0.12758152,-0.015756465,0.024363903,-0.04274719,0.08717671,-0.007105205,0.080948524,0.05573135,-0.019709032,-0.02195906,0.058217466,0.016104404,0.002327953,0.09049274,0.07009814,-0.09561893,-0.020482102,-0.021487216,-0.0070002023,-0.020680739,0.057040654,0.03299229,-0.047556024,-0.13746604,0.046523787,0.024736622,0.022506662,0.03829832,0.049218323,-0.034525722,0.007852756,-0.06003088,0.079753496,-0.0118131265,0.011377146,-0.015236344,-0.05060875,0.008284445,-0.02197999,0.08659431,0.0059023295,0.034088075,0.01829876,-0.011165533,-0.05258589,0.01799489,-0.016243665,-0.023261715,0.026852138,0.090325855,-0.007842376,-0.021249823,0.04194446,0.016305184,0.026775306,0.021405194,-0.021624481,-0.13910958,0.053135294,-0.026412511,-0.060270227,-0.034555927,0.022744223,-0.07904724,0.031328578,0.027230699,-0.03524499,-0.018189292,0.015392048,0.016474612,-0.033704188,0.020724207,0.010602038,0.07402333,0.038577847,0.0042244885,-0.01642206,-0.045570426,0.0016357596,-0.03930019,-0.052705128,-0.045659795,0.006620205,-0.007590444,0.048621375,0.023251612,0.02740293,-0.0061479104,0.014137834,0.09286234,-0.047659952,0.025407577,-0.08878606,-1.8031446e-34,-0.0355851,-0.018674623,0.043086022,-0.0020565446,-0.02382214,0.030029148,-0.034795653,-0.0594263,-0.007659955,-0.05204393,-0.076745406,-0.13203153,-0.047355037,0.033873077,-0.027039904,0.024775885,-0.071322374,0.013730411,0.055950023,-0.016890807,-0.032775417,0.1100073,0.007722975,-0.040971786,0.0996224,-0.03305424,0.00087302364,-0.041347764,0.023826791,0.016602838,-0.016144734,0.012627815,-0.06381101,0.0001850478,-0.015345243,-0.024015062,-0.011489182,-0.070899904,0.052984573,0.05828095,-0.044413943,0.086366035,-0.025185138,-0.013109544,0.09950407,-0.05205065,-0.033094198,0.064569235,0.0025083134,0.056981128,-0.046672273,-0.055152394,0.03212439,-0.055700615,-0.05680268,-0.08497789,-0.032905497,0.05299891,0.0784377,0.080724776,0.058094937,0.08851315,-0.09477076,0.04965378,-0.028980047,-0.017437305,0.010650163,-0.0031791881,0.04737102,0.1117725,-0.0131317545,-0.0028520518,0.0345139,0.029185098,-0.011203184,-0.108963,-0.09355823,0.07746711,-0.0039036886,0.023652457,0.008608367,0.018356742,0.026352827,0.0011421049,-0.047320243,0.07162185,-0.017990602,0.018736053,-0.042177536,0.06623069,0.06587709,-0.028637705,-0.05280786,0.052869644,-0.04061499,-1.4213182e-33,0.012883318,-0.04478029,0.05978888,-0.07568153,-0.072495446,0.04250888,-0.012889655,0.027490677,0.020464903,-0.005636508,0.025685841,0.010901816,0.039814442,-0.062794834,0.014751524,-0.0023375107,-0.029788617,0.05521354,-0.03881997,0.011699333,-0.026433272,-0.034186605,0.011057069,-0.008098062,0.011951705,0.007983643,-0.03502577,0.090327635,-0.018191367,-0.056737144,-0.059440657,0.039501958,-0.015473849,-0.033868372,-0.0806894,0.008715944,0.02008347,0.03371216,-0.0296163,-0.057787564,-0.030693587,0.09239701,0.04841033,0.019010479,-0.064422,0.08300474,0.02720822,0.0036894223,0.064062275,-0.029699208,-0.029072125,-0.08755369,0.04730009,-0.00568847,-0.026569923,-0.05679786,0.053175192,0.038062554,-0.04493067,0.0071502877,0.08176311,-0.026415702,0.038749997,0.030845404,0.08610989,0.004238628,-0.03038113,-0.011241449,0.07346215,-0.022720646,0.021938868,0.02499893,-0.04273624,-0.06362057,-0.015355584,0.07420546,-0.12824535,-0.07765021,0.03231738,0.018255131,-0.058878224,0.013104665,-0.053601444,0.050629657,0.013823025,-0.032659825,0.049888752,0.092551894,0.041730087,0.090344004,0.026793487,0.01774239,0.009671348,0.037474737,0.039152376,-2.5729262e-08,0.07778851,-0.120552264,0.031436704,-0.0433842,-0.08927925,-0.02500836,-0.019399894,0.025006864,0.016839404,0.0061692065,-0.007847468,0.11581329,-0.012153132,-0.012995484,0.011775279,0.023256687,-0.065991156,-0.008820208,0.022175517,-0.0077826763,-0.05753815,0.0013486356,-0.0025832755,0.012504705,-0.005077394,-0.079402745,0.01892612,0.011868587,0.018413609,-0.047286045,0.0029880502,-0.026606796,-0.056544684,-0.060636744,0.016539888,0.016957914,0.002010056,-0.055865634,-0.04510842,0.004861982,0.066700906,-0.060144622,-0.0552591,-0.038112726,0.05199097,0.043826334,-0.02743215,-0.023872532,-0.094305776,-0.043020587,0.07027558,-0.04196342,0.013155451,-0.010417792,-0.15370451,0.013495108,-0.002829045,-0.100560576,0.041108895,-0.017569264,0.06976749,0.040107626,0.15553497,0.080739975 +3.4.21.88,"RecA protein and single-stranded DNA are required for activity, which is attributed to a Ser/Lys dyad [2]. The LexA protein represses the SOS regulon, which regulates the genes involved in DNA repair. In the presence of single-stranded DNA, the RecA protein interacts with repressor LexA, causing it to undergo an autocatalytic cleavage which disrupts the DNA-binding part of the repressor, and inactivates it. The consequent derepression of the SOS regulon leads to DNA repair. This peptidase activity of LexA was previously attributed to the RecA protein. Type example of peptidase family S24",384,1.0,-0.115648076,-0.08538321,-0.042858217,-0.059606977,0.04099242,0.05392051,-0.015549776,0.10005008,0.015441082,0.02829309,0.05368892,0.096463844,-0.086196944,0.022621658,0.010705784,0.016067551,-0.099867314,0.003857815,0.0022191475,-0.04076099,0.043334596,0.027619569,0.02904703,0.028405255,-0.042382184,0.057378933,0.0032074302,-0.051814526,0.019133108,-0.11659256,0.07259084,-0.020816296,-0.011217418,-0.044094585,0.067808375,0.04771212,0.060181074,-0.0080578,0.023242952,-0.029213522,0.046819735,0.07324102,-0.051944777,0.0043691443,-0.0074656643,-0.043198317,0.007914211,0.087073945,0.040681027,-0.0258625,0.049517483,-0.026670923,0.0007625627,0.02376447,0.01823093,0.092241585,-0.0660558,0.018944671,0.065634325,-0.015007308,0.030193772,0.0043598837,0.019998865,-0.0131545905,0.04871527,-0.06735515,0.013463112,-0.05086738,-0.012829306,0.008683973,-0.024064811,-0.072721824,-0.011955919,0.07962974,0.005325247,0.037170608,0.0061692772,-0.03609098,-0.01803891,0.060163382,-0.022778444,0.037548464,0.103177115,0.08895345,0.03977211,-0.04150365,0.049729526,-0.025992641,0.093504526,0.0059164786,0.011993062,-0.117303036,0.0754599,-0.05257792,-0.08514463,0.04896475,0.021888906,-0.075648926,0.04505513,-0.0065434985,0.03860396,0.01373334,-0.012396588,-0.031881947,-0.08704693,0.042152647,-0.084316835,0.034769755,0.047020875,0.01027733,0.019240547,-0.024796642,0.07976731,0.015428257,-0.08217843,-0.020019056,-0.07103862,-0.011430583,0.012932786,-0.05905122,-0.023572063,-0.0032893557,-0.0013709738,0.005041974,0.015295509,0.028524967,-0.08702591,8.506467e-34,-0.018327123,0.02095493,-0.0019821434,0.03844429,0.004285915,-0.040367167,-0.031584892,0.026388204,0.0067716073,-0.0494154,-0.0026779028,-0.06014437,0.04218129,-0.026970377,-0.1284865,0.08442542,-0.01060948,0.0013610967,-0.038326774,-0.011028853,-0.052326176,0.06788568,0.043882962,-0.100723915,0.09394197,0.027809119,0.048219416,0.0068109543,0.088307254,0.0003343713,-0.05521051,-0.000844919,0.0040661963,0.06779257,0.052872803,-0.009853965,0.056317512,-0.06044596,-0.026875755,0.0359719,-0.023878211,0.08917049,-0.09744138,-0.0350347,0.063884415,-0.11250303,-0.015854072,0.0054252613,-0.075231746,0.028701354,0.023010924,-0.016531322,0.008984299,0.023184406,-0.098212756,0.008114537,-0.036799084,-0.012673931,0.012083719,0.02049288,0.051504336,0.018382447,0.027754763,-0.05743238,0.033406034,-0.027320482,-0.036768645,0.0038824768,0.006822523,0.109923765,-0.03026868,0.022691865,0.04461111,-0.006225571,0.01761881,-0.051545512,-0.058766536,0.073628195,0.008844636,0.07214083,-0.024131473,-0.015789893,0.0018700429,0.018627323,-0.02616391,-0.09996231,-0.03210685,-0.03351877,-0.063516736,0.0056652795,0.099217765,-0.12770893,0.023870837,0.024023252,0.019069219,-3.0751006e-33,0.020110343,-0.057091605,0.035826985,-0.068620756,-0.016320217,-0.0028527125,0.014545126,0.08749107,0.023774303,-0.06806244,-0.0147666475,-0.059434198,-0.024853874,0.013270189,0.03213937,0.051250026,-0.05678759,0.05289414,-0.0801116,-0.031457216,0.005172746,0.070337854,0.056586362,0.13319397,0.05949589,0.006093832,-0.063709915,0.11521283,0.023608329,-0.021962335,0.040486783,-0.008008316,-0.033795442,0.016352512,-0.025589826,0.030794898,-0.043795068,-0.0031274972,0.02496729,-0.05391005,0.030380463,0.06724318,0.03957019,0.12263675,0.015335503,0.011929644,-0.06710533,0.035700798,0.05295436,-0.040907033,0.00034068004,-0.1064632,-0.016668864,-0.029058896,0.033304624,-0.0074739247,0.027301945,0.021248609,-0.11413266,0.10055723,-0.030266836,-0.05547928,0.002545499,0.09151995,0.048000693,-0.025006294,-0.04648536,-0.036952868,0.081220634,-0.046243235,0.115739994,0.044688042,0.008315046,0.043581147,0.013522051,0.025264105,-0.100458875,-0.094064474,0.022922471,-0.048570454,-0.09495523,-0.008693991,-0.025707407,0.0071584266,0.103262775,0.0003393137,0.01984092,0.06982771,-0.008747036,0.017504288,0.030669471,-0.054786544,0.007895831,0.08053932,0.048346516,-4.165155e-08,0.051567446,-0.08222241,-0.036218386,-0.04223381,-0.06660644,0.01543753,-0.016975518,0.032462373,0.007484915,-0.070301235,0.011875779,0.03574124,-0.010417348,0.067682825,0.014398858,0.027639577,-0.039775148,0.051574703,-0.07101651,-0.048068717,-0.026846934,-0.019664017,-0.04588815,0.07986568,-0.017901333,-0.034167167,0.024800118,0.06859062,-0.061884712,-0.11799066,0.013585922,-0.028183647,-0.017296776,0.02782762,-0.0070305727,-0.0060116122,0.081966504,-0.036086317,-0.024661288,-0.017286686,0.051442318,0.030169122,-0.053063784,-0.022635221,-0.02652053,-0.016261058,0.003759355,0.017515486,-0.048512887,-0.029327812,0.027308043,-0.02629625,-0.06429198,-0.09732762,-0.13432766,-0.02765367,-0.030835006,0.019943355,0.042052787,-0.04167793,0.030343793,0.019842507,0.10739663,-0.031952955 +3.4.21.89,"The enzyme is found in bacterial membranes and in chloroplast thylakoid membranes. Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity [1,3]. Hydrolyses a single bond -Ala!Ala- in M13 phage procoat protein, producing free signal peptide and coat protein. Formerly included in EC 3.4.99.36. Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane [4] and mitochondrial inner membrane [2]. Type example of peptidase family S26",384,0.99999994,-0.0836451,-0.07984811,-0.10414065,-0.10945008,0.10550479,0.047729347,-0.033733264,0.05624918,0.08778265,0.016259125,0.05540226,0.003709681,0.0015280928,0.054618765,0.033458997,-0.025271917,-0.113771245,-0.014391357,0.0066549988,-0.07756976,0.089766234,0.020165147,-0.009206785,0.0034395216,-0.031438652,-0.011580606,0.021981493,-0.08212525,0.0036148604,-0.03792414,-0.016174674,-0.059605975,0.030253148,-0.05851916,0.100590795,0.032810446,-0.025529683,-0.023724034,0.040014237,-0.049766507,0.04892978,0.020535866,-0.036784228,-0.06337145,-0.015814962,-0.028555728,-0.016363688,0.04972545,0.022610664,-0.04379989,-0.015401851,-0.051001947,-0.038244177,-0.002942155,0.004733303,0.01294934,-0.040273815,-0.012004573,0.050548844,0.021866523,-0.026931854,0.013309739,0.053657074,-0.054330043,-0.00018931595,-0.041267864,-0.0035161162,-0.02862441,0.06333867,-0.024379607,-0.031435844,-0.07701182,-0.046687435,0.09963687,0.028425254,0.048775136,-0.019889036,-0.02947247,-0.074656144,0.021004474,-0.019630363,-0.016309952,0.03186023,0.10924566,0.04164077,-0.01665965,0.023264654,-0.034244724,0.070143126,-0.024304444,0.073599935,-0.0930872,-0.03494718,0.043898135,-0.11461231,0.0049807252,-0.014207634,-0.03249319,-0.01047147,-0.023478186,0.020555861,-0.0001950505,-0.009326841,-0.03454287,0.009815884,0.08062631,0.0006797035,0.082481526,0.009045099,-0.045729455,0.006063099,-0.021809181,0.05064489,-0.061805233,0.009658102,-0.015699456,0.026652593,-0.028393587,0.022297457,0.033090986,0.017502,0.025717892,0.025664289,0.059890646,-0.010518968,0.08086176,-0.142419,5.070419e-33,0.0026969265,-0.014229652,0.042472716,0.03427277,-0.049048994,-0.02029323,-0.039605252,-0.02883087,0.03176357,-0.08059174,-0.10155324,-0.05034643,-0.03644104,-0.045330368,-0.078395225,0.0037676601,-0.007654315,-0.019316742,0.04299145,0.03733399,-0.02854931,0.06681689,0.02546708,-0.06607984,0.1307457,-0.020381624,0.013492309,-0.031913698,0.11681462,0.028067693,-0.019970011,-0.07084192,-0.09639566,0.044555776,-0.018978769,0.030788999,0.009020549,-0.03862594,-0.011133192,0.05321851,-0.030342607,0.04966419,-0.015895996,-0.041770253,0.07151385,-0.054129295,-0.02217456,0.09776311,-0.028227368,-0.0127218235,-0.02372884,-0.02351696,0.06985899,0.0033788264,-0.07060017,0.02453952,0.032491967,0.0033122457,0.0921221,0.092957854,0.080162846,0.059104968,-0.015873948,0.02711062,0.08384927,0.024504276,-0.036799155,-0.01717304,-0.0012826979,0.12185219,-0.067141175,0.05247682,0.09580268,0.056269247,0.05646703,-0.15913072,-0.0672515,0.041766495,-0.006748408,0.079279415,0.08007894,0.03162371,0.015152163,0.030799583,-0.028543292,-0.046269104,-0.014853948,-0.020160306,-0.09747504,0.04483036,0.075158514,-0.049829323,0.0009316372,0.09417848,-0.11330974,-5.4125872e-33,0.060399372,-0.09162285,0.10035354,-0.106211424,-0.07036645,0.04988523,-0.0015608143,0.026880555,0.026927883,0.008308489,0.076979876,-0.025847314,-0.016136112,-0.04097804,-0.012285784,0.01485321,-0.02610809,0.034287017,-0.027503202,-0.018170921,-0.061254073,0.025229538,0.022118827,0.09769291,0.0011806794,-0.021029696,-0.0012486236,0.0840596,-0.011670933,-0.032927062,-0.04265342,0.048486426,-0.059471417,-0.047081895,-0.07746278,0.015736923,-0.023455461,0.0074497294,0.021276142,-0.035500094,0.02317545,0.047414873,0.066223584,0.016092911,0.0066481237,0.03873809,-0.056177717,0.015995832,0.024882203,-0.086344995,-0.007865359,-0.07020212,0.01837817,-0.0011350414,0.048787124,-0.02706197,0.01885185,0.06459066,0.0027058024,0.05187142,0.018433766,-0.03936181,-0.03831657,0.01912311,0.040474847,0.03526881,-0.056427076,-0.025005234,0.08814614,0.00900686,0.044979386,0.022944989,-0.002471144,-0.024335496,0.0044156327,0.047992628,-0.082154945,-0.070792876,-0.0004536787,-0.06854442,-0.022820128,-0.03343846,-0.017477872,-0.021604834,0.057556007,-0.055459674,0.03244907,0.085253246,0.009468274,0.053416383,0.014268555,-0.029935922,-0.006714002,0.08997886,0.06575882,-4.1756394e-08,0.06750226,-0.015336971,0.028203921,-0.03858796,-0.08743976,0.040081363,0.0073692924,-0.003834704,0.008062542,-0.039877273,-0.043057043,0.030474544,-0.024410931,0.03319263,0.0032046526,0.103144534,-0.056626335,0.043691564,0.0075262003,-0.016241547,-0.0013333089,0.011962211,-0.091194674,0.059958044,0.02219565,-0.03641024,0.05201954,0.04415118,-0.033356145,-0.06993138,-0.024236927,-0.04434341,-0.05073825,-0.019199293,0.030315097,0.021048134,-0.04999818,-0.054816853,-0.018986944,0.06699527,0.047756806,-0.04716899,-0.08328366,-0.04684652,0.050043255,0.030788885,0.006912937,0.053219277,-0.06575647,0.00785861,0.065580525,-0.022587478,-0.017472442,-0.057090838,-0.123292096,0.018869147,0.008874402,-0.07867126,0.0195262,-0.05880028,0.057081714,-0.016051553,0.15581857,0.047722314 +3.4.21.90,"Known from the Sindbis and Semliki forest togaviruses. Once released, the core protein does not retain catalytic activity. Togavirin is the type example of peptidase family S3 and has a similar tertiary structure to chymotrypsin [3]",384,0.99999994,-0.06148574,-0.05985678,-0.14634453,-0.045374077,0.10271969,0.076016136,-0.023280224,0.012533979,0.04216906,0.057020795,-0.027302332,-0.025886033,-0.020237267,0.068103336,0.0126518635,0.0064941347,-0.07361891,-0.0032587142,0.061457757,-0.08909949,0.0109849535,0.0137452865,-0.012197582,0.028765818,-0.019458555,-0.011087013,-0.036400836,0.015138883,-0.0014456431,-0.052283116,-0.046720598,-0.0041735535,0.038410418,-0.021479024,0.03573525,0.1014603,-0.0036500092,-0.021737099,0.014796146,-0.025067337,0.00021143345,0.06984342,0.008091464,-0.042660855,0.013577602,-0.020391988,-0.06832295,0.05304507,0.03577911,-0.06875298,0.002343655,-0.07746512,-0.004010919,-0.023412768,-0.0141429845,0.032982845,-0.05034418,-0.03203737,0.016017182,-0.01839725,0.074023895,0.027784597,0.002330018,-0.0013299301,-0.0014253509,-0.07513433,0.0037544582,-0.0032440342,0.008476164,0.020582426,-0.022277392,-0.06614376,-0.118363984,0.07784859,0.008403398,0.09153821,0.044326637,-0.02245145,-0.01966959,-0.05239829,-0.036191348,0.046715867,0.10560616,0.09298647,-0.05106768,-0.056437783,-0.020755786,0.008581108,-0.024009772,-0.014590072,0.03119337,-0.047690053,0.10638669,0.017304374,-0.004099086,0.018171199,0.04842494,-0.079831205,0.036837894,-0.0140197575,-0.026833441,-0.06687413,0.019158486,-0.063698046,0.0038267549,0.067374185,-0.06834698,0.07283201,0.090983614,-0.022430591,0.036277074,0.0360945,0.0635925,-0.032638352,0.04988142,0.030077297,-0.03223094,-0.014153943,0.004666551,0.06601462,0.09971062,-0.023327544,0.020748714,0.025045402,-0.052107982,-0.010086603,-0.025105365,2.4657972e-33,0.04160015,-0.022532873,0.00088660076,0.01389621,-0.06924658,-0.007723187,0.03293594,-0.024980964,-0.023716863,0.03858378,-0.102279566,-0.008528023,-0.010941642,0.02540055,-0.09754956,-0.0041256715,-0.058408465,0.05757045,-0.03983004,0.041260317,-0.0031345407,0.13558914,-0.0015339192,-0.019459559,0.15927216,0.012731035,-0.013603967,-0.05435014,0.03343517,-0.0110129975,-0.0014628717,0.037059527,-0.12519684,0.044436082,-0.04662813,0.022970697,0.07170401,-0.048327997,-0.03946,0.05291101,0.12919714,0.024608644,-0.036488935,-0.052031726,0.06713238,-0.012750851,-0.06706044,-0.034310665,-0.08255139,0.010201399,0.02994629,-0.012295204,0.0791933,0.039394032,-0.08767033,0.007017082,0.053658266,0.031274892,0.05465015,0.024202682,0.029434571,-0.024294263,-4.0303075e-05,-0.008765695,-0.024398347,-0.03826758,0.016939387,-0.031218551,-0.07329681,0.07972709,-0.064237155,0.09404027,0.045706045,-0.007930671,0.07112475,-0.13049766,-0.09862828,0.014958412,-0.043332614,0.047502708,0.0038345198,0.008828262,0.06706473,-0.03064586,-0.018029228,-0.03246691,0.011761026,-0.029456584,-0.0664833,-0.0021408314,0.0021494057,0.041351393,0.027835071,0.090057045,-0.053214073,-3.3994415e-33,-0.051281556,-0.08376839,0.042027414,-0.012637772,-0.07259432,0.12408046,0.031054173,-0.010987224,-0.027038703,-0.120201744,0.04488757,-0.029560566,0.0070164553,-0.06927297,0.073885754,0.048196673,0.037112646,0.045833644,-0.104420625,-0.0074941823,-0.06807332,-0.05449233,-0.029562155,0.020634223,0.036365915,-0.0039503984,-0.051552653,0.030191388,0.036475834,0.030780591,0.0086074965,0.027381446,-0.04099655,-0.048974976,-0.064733006,0.0019902212,-0.06995775,-0.017025413,-0.042306114,-0.016653078,0.015470649,0.099438414,0.059833042,0.087515324,0.04079394,0.07781641,-0.0048517506,0.05488286,0.047709428,0.017966537,0.037654053,-0.13502695,0.018300217,0.013821399,0.026359104,0.02821499,0.026756568,0.04230185,0.009077564,0.017804181,-0.012580458,-0.012182041,-0.030948253,0.05054191,0.070971034,0.11782575,-0.077125154,-0.019322764,0.04860122,-0.027138827,0.027034486,-0.023553537,0.03362535,0.006025854,0.028517673,0.043475095,-0.05611452,-0.048916034,0.0011346403,-0.078701206,-0.045060292,0.014447027,0.019457258,0.0012448328,0.07749868,-0.045927033,-0.004588767,0.025913384,0.0397071,0.028427342,-0.012582596,-0.008036539,0.025279079,-0.00882674,0.018600067,-3.4183703e-08,0.12235207,-0.020923182,-0.004204519,-0.036681864,-0.036899492,0.01862683,0.0020765213,-0.0006375765,0.09105425,-0.020560928,0.022350894,-0.016245227,0.031210927,0.009732645,0.04801012,0.03957382,0.019028148,0.045929763,-0.034500316,-0.00026846494,-0.07141857,0.036574043,-0.08080902,0.025583474,-0.00113715,-0.00991364,-0.02786641,0.03862707,0.09613047,-0.055776138,-0.058805466,0.02737967,-0.04911921,0.005688119,-0.024966666,0.0145865455,0.033855658,-0.04749808,0.059533346,-0.016768122,0.0574488,-0.08070368,-0.041744772,-0.060845055,-0.12284023,-0.03443904,-0.030125773,0.0038831774,0.02390521,-0.044308867,-0.030843338,-0.025639169,-0.07586447,-0.06815292,-0.070920855,-0.00048613723,0.030769847,-0.031650234,0.06329643,-0.1328608,-0.01723454,-0.09158023,0.124151066,0.035331808 +3.4.21.91,"Known from classical flaviviruses (yellow fever, dengue fever). The functional viral peptidase is part of the NS2B protein. Catalytic His, Asp and Ser residues are arranged as in chymotrypsin, but flavivrin is the type example of peptidase family S7.",384,1.0,-0.0655979,-0.06868452,-0.11728126,-0.014904467,0.11003876,0.077267714,0.03521463,0.038840868,0.06839703,0.04119815,-0.032568157,-0.012661111,-0.044227947,0.10638656,0.035333823,-0.036076833,-0.11799416,-0.05674192,0.009552563,-0.057185475,0.01531161,0.07219273,0.02870032,-0.026996255,-0.11610217,0.01218988,0.002677966,-0.004454425,0.052293144,-0.07049378,0.07131451,-0.029996062,0.060095653,-0.040548194,0.03052518,-0.015473156,0.040465545,-0.055265784,-0.013525651,0.010551612,0.046529736,0.08478605,0.0858836,-0.028480655,0.048361156,0.0141312145,-0.0042672176,0.064862005,0.084355265,-0.038433794,-0.004341137,-0.076544665,-0.07044491,0.052961648,0.06545454,0.052159555,-0.10460593,-0.10612042,0.042252503,-0.02034701,0.04549918,0.098774865,0.04466979,0.011278679,-0.0010068608,-0.06706489,0.0025394512,-0.016034579,0.06304535,-0.01557137,-0.023268705,-0.050965827,-0.079606466,0.16366774,-0.0075746737,0.05904629,0.088132046,-0.024617348,-0.04028148,-0.049282353,-0.0033668657,-0.03873658,0.11965168,0.086162865,-0.0042716204,-0.04318716,-0.05746038,-0.010747006,0.0654187,0.0055829347,0.046124082,-0.0645367,0.094012305,-0.015056295,-0.031424563,0.020297023,0.054565445,-0.046809494,0.019885745,0.05431582,-0.030901698,-0.048322704,0.054270692,-0.034724314,-0.0089708,-0.002102707,0.0013055952,0.053389598,0.046433587,-0.020120112,0.021215534,0.0059820474,0.08969172,-0.104746506,0.011743094,-0.02750541,-0.050860617,-0.032633383,-0.028600812,0.012327602,0.062684916,0.00655518,-0.016261121,0.05365234,-0.06495352,0.015476082,-0.0714572,3.568268e-33,0.01774368,-0.07332849,0.0451085,0.020445053,-0.020075697,-0.03541455,0.01770545,0.024724543,0.023986928,-0.092679664,-0.06330828,-0.04285387,0.013448777,0.045429148,-0.024355425,0.023809822,-0.07037357,-0.036331102,0.03392202,0.0352776,0.012409652,0.12233362,0.058111396,-0.012368134,0.1487032,0.019173885,0.015869267,-0.025736973,0.06469542,0.0024967478,-0.035910998,0.041101273,-0.07790976,0.034789685,-0.03257926,0.008769619,-0.043593932,-0.08326764,-0.061336644,0.06590563,0.04475401,-0.015889475,-0.10218483,0.037324835,0.042611398,-0.029569447,-0.073650815,0.04568905,-0.0054886467,-0.0076233554,0.027726278,0.010678083,0.019693267,0.036630668,-0.0438986,0.042011872,0.013351983,-0.01849862,0.055802867,-0.008654884,0.05991386,-9.46294e-05,-0.0001576154,-0.008447452,-0.017993456,-0.013408604,0.028845472,-0.053908814,0.00163163,0.05925365,-0.017181441,0.043784317,0.08298828,-0.007818175,0.05250999,-0.10479406,-0.040975224,-0.07990367,-0.048924476,0.048986915,-0.032252867,0.006544781,0.09157618,0.053406287,-0.049329747,-0.047889058,0.0040717237,-0.034463547,-0.10747459,-0.019948024,-0.025081364,-0.010307795,0.005767816,0.04068973,-0.059324298,-3.9647665e-33,-0.037344057,-0.044381462,-0.042770218,-0.0362683,-0.063561134,0.066599086,0.044171587,-0.04019744,0.00071202876,-0.03995613,0.00085076777,-0.05756023,-0.009031167,-0.06360596,0.028106878,0.021331498,-0.019507412,0.08407648,-0.0283314,0.009698436,-0.054835014,-0.009975276,0.03945084,0.04496671,0.02572187,-0.013755613,-0.0061779656,0.02339956,-0.035212625,0.03297941,-0.011942695,0.039226513,-0.06816011,-0.05001598,-0.11856,0.0023702786,-0.01897887,-0.025182102,-0.018422121,-0.050229494,0.034862116,0.09698082,0.05783329,0.032427315,0.0027385775,0.10358684,0.004714744,0.05522927,0.009227585,-0.04189227,0.01720324,-0.0917449,-0.0135383485,0.07128816,0.0021826443,0.005420156,-0.017008156,0.014708491,0.070084155,-0.01209744,0.026162224,-0.058793195,-0.027563343,0.03248137,0.10269173,0.041882873,-0.0033722827,0.05832959,0.038379923,-0.05624174,0.047856677,-0.022210767,0.052740626,0.06840782,0.012737735,0.02155606,-0.010227138,-0.037189167,-0.018210342,-0.04940331,-0.003708525,0.008633995,0.063351616,-0.025310075,0.0040491438,0.01343205,-0.016459128,0.042848527,0.06297105,0.052491035,-0.01834711,-0.01733853,0.040663924,0.013824548,0.011086861,-3.270669e-08,0.06807346,-0.09255272,-0.034255877,-0.042617634,-0.07041527,0.04091004,-0.0699992,-0.0065082014,0.049188025,0.0006176629,0.008550111,5.2047475e-05,0.043067653,0.010747553,-0.025136372,0.093712516,-0.06523561,0.037032768,-0.055901334,-0.024038471,-0.05575451,0.0647323,-0.074918896,0.04301352,-0.036773697,-0.037269156,-0.06868102,0.029213103,0.03912936,-0.06516717,-0.07046931,0.024430381,-0.015196374,-0.036296338,-0.039268907,-0.007554992,0.09093032,-0.07208628,0.020352693,0.0019860682,0.04105384,-0.04318456,-0.004593581,-0.044582028,0.0052426322,-0.034650456,-0.024923487,0.044902705,0.021274239,-0.042685285,0.032226253,0.0043287417,-0.064607315,-0.053924903,-0.14706527,-0.07710948,-0.06063608,-0.037299134,0.04519105,-0.10163802,0.014021087,-0.034473166,0.11738689,0.07519444 +3.4.21.92,"An enzyme from bacteria that contains subunits of two types, ClpP, with peptidase activity, and ClpA, with ATPase activity. The ClpAP complex, which displays ATP-dependent endopeptidase activity, has the composition (ClpP14ClpA6)2 [4]. ClpP is the type example of peptidase family S14",384,1.0,-0.028907709,-0.040934447,-0.028396087,-0.09496303,0.04114009,0.06888537,-0.03608948,0.09665102,0.053988334,-0.02130898,0.0651048,-0.08993245,-0.011204005,0.12086485,-0.01604107,-0.016635824,-0.077343516,-0.015181418,0.08187966,-0.01604032,0.03402637,0.062302478,-0.05969665,0.042127546,-0.04465967,0.10380345,0.06585237,-0.05059634,0.008028102,-4.8262e-06,-0.022913508,-0.02655167,0.12705894,-0.03934326,0.101909645,0.05352881,-0.0034999812,0.015245185,0.09065315,0.0010264083,0.02758335,0.051204845,-0.016158372,-0.050182257,0.07280797,-0.03299676,0.019822279,0.039819535,-0.014449647,-0.017225543,0.016926233,-0.054719254,-0.031483006,0.009619462,0.08879923,0.015281533,-0.08756546,-0.049275775,0.010701878,-0.0044745333,0.033709813,-0.027879676,0.015755532,-0.014172732,0.050804574,-0.0657324,-0.015355772,0.019052,0.03545183,-0.030810539,-0.07849202,-0.037324585,-0.06792613,0.08949062,-0.020171257,0.021397239,-0.010145548,-0.03285434,-0.057729956,-0.06512511,-0.017038727,0.004328424,0.010290418,0.06548215,0.057311006,-0.037440617,0.045966238,0.034076516,0.043646254,-0.02128587,0.0024889663,-0.09381972,0.0090975985,-0.027190777,-0.025229158,0.03309546,-0.06654206,-0.060696207,-0.0011160625,0.0054293796,0.04970193,0.02493938,0.03515502,-0.087372005,-0.004967634,0.06889257,-0.020387376,0.033144142,0.050134867,-0.0029211468,-0.012446477,-0.0011415018,0.01781028,-0.050217494,0.07039149,0.025321025,-0.00085594045,-0.014913623,0.0006442378,0.060981415,0.025688149,-0.08075899,0.0051666372,0.06333562,-0.05459535,0.06128655,-0.03561623,1.943096e-33,0.003894148,-0.04377451,0.017629463,0.0025075746,0.029825728,-0.0066264756,-0.014306045,-0.0010555526,-0.06331882,-0.06918556,-0.017751897,-0.047928505,-0.02574429,0.043194722,-0.01093292,0.033731464,-0.10856567,0.060270905,0.06605686,-0.02042417,-0.021727094,0.12008986,0.025694357,-0.046606377,0.12395592,0.03868199,0.01220436,-0.034717698,0.056706302,0.006442287,0.055429414,-0.014955218,-0.12979919,-0.013173895,-0.021953903,-0.026389165,0.027275987,-0.09436938,-0.007456599,-0.016386045,-0.054437645,0.0024952372,-0.057203025,-0.018897329,0.08988058,-0.105905004,-0.013035692,0.07559473,-0.03893464,0.0351107,-0.0060892687,-0.036396474,0.030412871,-0.063691236,-0.047655396,0.013320045,-0.007343849,0.060356613,0.04830041,0.07169454,0.084989026,0.0976274,-0.0846873,-0.049942024,-0.008523782,0.020189893,-0.1085045,-0.08570329,0.043890286,0.109323494,-0.02073577,0.03400355,-0.010495727,0.035755675,0.048336342,-0.11404987,-0.06088011,0.056679964,-0.027390337,0.06455573,0.009238305,-0.0022992773,0.04989367,-0.046732515,-0.06352449,-0.054419316,-0.042372536,-0.04969526,-0.09352545,-0.025957776,0.007390073,0.0034403787,-0.026782064,0.13748,-0.0526549,-2.2228914e-33,0.04662016,-0.090216905,0.050606575,-0.09834062,-0.05801553,0.045412585,-0.053487975,-0.035880852,-0.0007087097,0.010255349,0.046677228,-0.058252826,0.0247074,-0.04525824,0.0009881414,0.013157395,-0.02563636,0.07192003,-0.022862893,-0.024974585,-0.053098727,0.01755162,0.06436627,0.05244975,0.021233015,0.052759312,-0.032320827,0.04664313,0.030509157,0.0069867,-0.011929856,-0.018055959,-0.00017509492,0.0029224562,-0.099112265,0.015111366,-0.05848984,0.023696331,0.01708694,-0.015331811,0.03423896,0.06572178,0.061643314,0.017072808,-0.0026917853,-0.0124431485,0.0049672076,0.030857723,0.005268267,-0.09347033,0.0073448224,-0.043828133,0.0002836672,0.019347783,0.01554374,0.014363678,-0.023814833,0.03163877,-0.009218434,-0.07137523,-0.011777844,-0.069565035,-0.020484813,0.081810676,0.11345489,0.025706774,-0.11338437,-0.045023825,-0.016569296,0.015335611,0.012434823,-0.023398422,-0.015181599,-0.016570127,0.033518422,0.06830242,-0.07362208,-0.07225508,0.010344126,-0.029475586,-0.04859942,-0.05869214,-0.0009804516,-0.016971039,-0.025867742,-0.038815398,-0.04708955,0.03521666,0.026253058,0.08986896,-0.016768156,0.03153971,0.019902354,0.05895326,0.053594094,-3.4358866e-08,0.04696855,-0.08292768,0.034798764,-0.014431811,-0.035131864,-0.013803129,-0.024181651,-0.025648523,0.055271648,0.026365284,-0.013565812,0.029876359,0.024125531,0.036014114,0.0465078,0.08632909,0.0015120907,0.01062024,0.009646627,-0.028953759,-0.03701212,0.004569404,-0.03480957,0.086819224,-0.0033056168,-0.060407385,0.0016604731,0.09771628,0.0009401682,-0.032119963,0.014840028,0.0014732947,-0.015214123,-0.045084167,0.022712583,0.06457786,-0.060246322,-0.02429342,-0.061179988,0.100284606,0.063242614,-0.043797355,-0.08879531,-0.03170187,0.0486771,0.023904718,0.0666018,0.0064688553,-0.08142917,-0.040319886,0.03381464,-0.04799942,0.016120112,-0.039458346,-0.096150555,0.04271874,-0.026493633,-0.100580774,0.029746462,-0.069830246,0.039641585,0.07439561,0.18473183,0.07153811 +3.4.21.93,"A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family)",384,1.0,-0.061650712,-0.050951995,-0.075188845,-0.0071306066,0.07611911,0.097115435,-0.035842188,0.10776775,0.079366714,0.08088076,0.03528856,-0.03087456,-0.028651074,0.08187339,0.008876842,-0.012592523,-0.116626486,-0.019472469,0.026371319,-0.13932146,0.09441308,-0.046163812,0.01564061,0.028594686,-0.046429444,-0.023205945,0.0020500727,0.03032188,-0.04054385,0.027338734,-0.025794744,-0.11426426,-0.05072203,-0.019785833,0.08935222,0.09212107,-0.08976953,-0.011180499,-0.0077384226,0.027870344,0.12710188,-0.002424219,-0.06965651,-0.038005237,0.00979764,-0.015525299,0.019445682,0.00453139,0.017436557,0.035622437,0.010864902,-0.05282783,0.0012779915,0.04021187,-0.020766063,0.07215553,-0.024218792,-0.011355393,0.027351176,0.049765352,-0.028557122,0.044048604,-0.014703664,-0.023485158,0.06256933,-0.0136384005,-0.008647563,0.0058005215,-0.06852816,-0.002458174,-0.020932302,0.014728843,-0.0174893,0.042467553,0.033646643,-0.032431547,-0.112552516,-0.05013586,-0.06182651,-0.09432885,0.06632774,-0.015453226,-0.020628873,0.061188877,0.02458931,-0.030099405,0.07082258,0.035123173,-0.014230939,-0.029027639,-0.0060187434,-0.05613549,0.036572266,-0.028807554,0.020538924,-0.016365744,-0.07260905,-0.06900447,-0.012919405,-0.024883,0.0004036245,0.044304196,-0.04512288,-0.09805876,0.012631087,0.06837226,-0.025441581,0.04521488,0.04434549,0.04177853,0.040591523,0.03366965,0.04117103,-0.010367813,0.044602036,0.1467159,-0.054084238,0.06984653,0.009212091,-0.005871021,-0.03855637,0.009277538,-0.012039496,0.052481633,-0.028468246,0.03632132,-0.09601706,6.2115024e-33,0.036146402,-0.03531417,0.048244037,0.06340307,-0.027407678,0.034338914,-0.04285645,0.006883863,0.052562114,-0.045715414,-0.044141993,-0.11520238,-0.06737686,-0.0016352786,0.011806039,-0.062342413,0.039976045,-0.034747843,0.06682367,0.028066384,0.012073482,0.045298968,-0.02247927,-0.027902292,0.07157244,0.047187094,0.005703725,0.06763503,0.042732377,-0.028870612,-0.02645679,-0.038657352,-0.022660574,0.037919305,0.05557448,-0.052813753,0.08421517,-0.032477107,0.032523025,0.028211564,-0.028600872,-0.04617683,0.021282613,-0.038419146,0.009842372,-0.08580393,-0.07403163,-0.06338648,0.06606697,0.04610314,0.016787995,-0.009104306,0.04794949,0.017373877,-0.1291863,-0.058276426,-0.012778555,-0.055876672,0.052300557,0.01930209,0.05817857,0.001960768,-0.004094293,-0.033757742,-0.02359524,0.038030703,-0.0926301,-0.071575485,-0.05315931,0.076132156,-0.065123856,0.04223402,0.043650623,-0.0096567515,0.08440752,0.011011927,-0.034412447,0.071772814,-0.025963038,-0.012672269,-0.019328272,0.005897742,-0.018499749,0.10092694,-0.021321276,-0.046963654,0.009685691,-0.042118315,0.005767161,0.04468918,0.05262305,-0.059896946,0.01856479,0.05158437,-0.017356154,-7.025547e-33,0.029187506,-0.045557532,0.059345033,-0.08731712,-0.011041673,0.049775425,0.00010729284,0.023434842,0.018820018,0.0039857496,0.017570667,0.014201521,0.02628363,-0.069152966,0.011042632,-0.007960573,-0.03465813,0.12802027,0.040261067,-0.041493773,-0.010695492,0.11994288,0.012463075,0.056094598,0.12412153,-0.004025402,-0.009501564,0.10547103,0.01508084,0.047283866,-0.10300033,0.019843439,-0.08467002,0.0037915756,-0.09000533,-0.0386831,-0.0649157,0.011600215,-0.06530701,0.022360204,-0.0061038905,-0.007390213,0.039198965,0.1214971,0.014193303,0.051576223,0.011701086,0.021020556,0.004234615,0.04137611,-0.052057385,-0.05119439,-0.026222505,-0.051464956,0.012844809,0.0088474825,-0.01272233,0.020096365,-0.024041992,-0.007900365,-0.0027344585,-0.0045099487,-0.007983279,0.0011918382,0.041122865,0.01949961,-0.042812053,0.011379244,0.09049704,0.03968778,0.101869844,-0.04262042,0.035884555,0.035544664,-0.020513415,0.0010893971,-0.110613845,-0.050570995,0.04805583,-0.04559749,-0.036619954,-0.028757935,-0.010622311,-0.078779355,-0.027575882,0.003621824,0.048400402,0.030559933,-0.014345855,0.012725046,-0.022043409,0.03764164,-0.008402189,0.026136976,-0.0093447445,-4.5244104e-08,0.06265473,-0.058165636,0.04069688,-0.051832546,-0.042251993,-0.09889842,0.046094753,-0.015056273,0.06356304,-0.03624425,-0.070116475,-0.016873898,0.02489044,0.0008563854,-0.04910928,0.11786945,0.035954975,0.12546551,-0.011723096,-0.03803064,-0.08348886,-0.0450146,-0.082825825,0.017509064,-0.043712173,-0.055258118,0.006078962,0.12291544,-0.0139631,-0.054461572,0.058954295,-0.013598521,-0.031079745,-0.0067345332,0.036101416,0.06686005,-0.0507902,-0.0015935224,0.01913691,-0.013655365,0.0021477826,-0.04754071,-0.014161333,0.02619218,-0.019051323,0.023571536,0.07650994,0.0066783726,0.049643837,0.0051316423,-0.015287498,0.0016702764,-0.06245837,-0.09806466,-0.08050357,0.027224815,-0.025930779,-0.04813138,-0.017945107,-0.068950675,0.022814054,0.030903157,0.17665386,-0.023701781 +3.4.21.94,"A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)",384,0.99999994,-0.078836866,-0.06009282,-0.078191996,-0.013389404,0.06919821,0.09198876,-0.033042714,0.09620537,0.08495823,0.09168387,0.039440785,-0.025780942,-0.04316292,0.09563474,-0.0019469407,-0.012325984,-0.10447651,-0.018535413,0.010915979,-0.12964918,0.08109535,-0.044889797,0.024297375,0.018463904,-0.0339599,-0.027594479,0.002231927,0.029968219,-0.035959274,0.020543808,-0.03351158,-0.114699714,-0.061965797,0.0035214613,0.10062218,0.0939464,-0.12161209,-0.004975161,-0.011410954,0.031450022,0.14177392,-4.615377e-05,-0.076602735,-0.04874431,-0.016533861,-0.026672138,0.009629986,0.016838022,0.023165176,0.03219478,0.01665042,-0.042080138,-0.0055982326,0.04547049,-0.019248458,0.0700141,-0.025875667,-0.009766467,0.018485812,0.053459704,-0.05036745,0.041222207,-0.013083767,-0.02133717,0.04891473,-0.014627428,-0.005561986,0.011720976,-0.06885265,0.006124405,-0.0173743,0.012838023,-0.010133505,0.029700322,0.037697863,-0.025589287,-0.10996854,-0.046995882,-0.06987055,-0.10944612,0.06391677,0.0016664086,-0.023524618,0.054235447,0.043001276,-0.034755062,0.065716736,0.055033173,-0.016036788,-0.01684679,-0.012445166,-0.07768769,0.030161822,-0.027892172,0.023601238,-0.009185707,-0.065090664,-0.066702396,-0.010134143,-0.031493008,-0.023173343,0.036878485,-0.026030121,-0.104969464,0.019684058,0.08397425,-0.038590603,0.054074947,0.040741563,0.040759496,0.025348121,0.032915838,0.043257866,-0.012379902,0.049476065,0.13424669,-0.042333733,0.07442227,0.00927325,0.013372527,-0.04113016,-0.0034725126,-0.0017791237,0.060338866,-0.029184747,0.04657961,-0.07679155,5.9596135e-33,0.031172926,-0.043355007,0.045330968,0.05397366,-0.023828922,0.04965025,-0.03399936,0.004888249,0.05530665,-0.055642065,-0.020987008,-0.12093275,-0.056984514,0.014000059,0.008518475,-0.05582195,0.03764813,-0.018596986,0.058599997,0.017296059,0.013503908,0.02452684,-0.04111635,-0.038896367,0.05970576,0.054940976,-0.011450473,0.08881336,0.044556167,-0.032017577,-0.022243414,-0.03140381,-0.024859989,0.039639585,0.0493276,-0.022725528,0.08248959,-0.04762241,0.03569605,0.030208899,-0.049635235,-0.048863128,0.003754256,-0.048957624,0.0104251085,-0.089477845,-0.06673292,-0.05064132,0.061683893,0.034050327,0.018152338,-0.013973128,0.065987274,0.010799961,-0.124356925,-0.07588746,-0.01699642,-0.05545481,0.05525334,0.009869635,0.080077276,0.003251675,-0.014298528,-0.016988005,-0.02388256,0.025202073,-0.095821716,-0.062273245,-0.056377843,0.06937005,-0.065942094,0.03364397,0.044184186,-0.009556105,0.0840655,0.017393043,-0.038848367,0.060839914,-0.041095342,-0.00780623,-0.041964136,0.00712649,-0.008228564,0.10355071,-0.036265615,-0.041187417,0.005230851,-0.052282322,0.00871106,0.041912258,0.06968155,-0.06242962,0.0052676457,0.056830548,-0.026447183,-7.133954e-33,0.03023295,-0.034840498,0.053171597,-0.091898076,-0.021899309,0.059644803,0.0017288621,0.024546728,-0.004020533,-0.011709095,0.013213914,0.010768927,0.017542506,-0.079797395,-0.0047928314,-0.010592431,-0.048052933,0.14423916,0.051323663,-0.029282492,0.010474503,0.113035,-0.0042821607,0.046783548,0.12263742,-0.009868601,-0.018426033,0.119906515,-0.006858169,0.061739124,-0.089473926,0.03319588,-0.080035895,-0.0084890835,-0.09020517,-0.039063726,-0.055423297,-0.009213652,-0.05295593,0.03089337,0.006728647,0.007348744,0.04810524,0.10893359,0.027970182,0.058110144,0.011340919,0.008081236,0.01910614,0.037591334,-0.05318808,-0.01645946,-0.026502438,-0.033133984,0.018146254,0.01760567,-0.011440603,0.013440502,-0.021359064,-0.022268383,-0.012792735,-0.005527782,-0.007654068,0.0037542486,0.041709147,0.022653367,-0.025452098,0.023394262,0.09525216,0.04069054,0.09563159,-0.031866096,0.0385421,0.01684892,-0.01458479,0.0073530604,-0.09560826,-0.043540783,0.0546084,-0.048165686,-0.03709455,-0.042621974,-0.03789794,-0.07617219,-0.02070685,0.007010692,0.05412778,0.04396222,-0.021683553,0.008068357,-0.013327977,0.018718453,-0.015441706,0.02343961,-0.024154184,-4.6834472e-08,0.067029275,-0.039431006,0.034579907,-0.054793622,-0.022547966,-0.0908767,0.0526393,-0.02349632,0.05581041,-0.02506438,-0.06328257,-0.016497254,0.031653613,-0.019726891,-0.032217465,0.114343524,0.025337173,0.11566187,-0.0049324357,-0.030348323,-0.06524453,-0.05234685,-0.106627375,0.0155639,-0.038225666,-0.05791965,0.009793014,0.12479688,-0.016023548,-0.04803582,0.045322914,-0.013465628,-0.021161702,-0.012195466,0.042528786,0.07153789,-0.054554947,0.002002215,0.018581519,-0.0022821068,0.0034245949,-0.050443504,-0.014488071,0.01996226,-0.008560573,0.04136205,0.06767355,0.0002489706,0.038377333,0.006239556,-0.008666032,0.0041557676,-0.056486994,-0.09428958,-0.078672536,0.0321729,-0.024423478,-0.044697125,-0.037209705,-0.065930516,0.024031997,0.032421313,0.16204222,-0.013411727 +3.4.21.95,"Known from venom of Vipera russelli. Inhibited by di-isopropyl fluorophosphate, unlike the metallopeptidase russellysin (EC 3.4.24.58) that is specific for factor X [1]. In peptidase family S1 (trypsin family) [2].",384,1.0,-0.026425123,0.0027216442,-0.055286255,0.021961538,0.060904417,0.052701112,0.085437216,0.017024675,-0.044854756,-0.022686532,0.056777153,-0.03204612,0.0716873,0.10883243,-0.08596075,0.019686932,0.027931347,-0.019483872,-0.0394297,-0.007131479,0.0011305669,0.014295867,0.07612149,0.00024831766,-0.095340945,-0.0021660277,-0.047299232,-0.044615787,0.045706812,-0.035423126,-0.030744765,0.05080375,-0.00022008174,-0.11032648,0.056468636,-0.016318042,-0.0118927425,0.028799588,-0.022273276,0.030158307,0.06320275,0.023697542,0.014704843,-0.001325631,-0.041539054,-0.046439663,-0.008386887,0.060085822,0.015452047,0.06466526,-0.010127821,0.0039042549,-0.04609816,-0.020122966,0.09598444,-0.02486699,-0.02352336,-0.03468408,-0.025520302,-0.021787116,0.022017114,0.056042943,0.01476777,0.03151388,0.025809554,0.0057391017,-0.0012871024,-0.05249903,0.010081283,-0.00010856397,-0.017044773,-0.06910197,-0.0348772,0.03353303,0.02935282,0.10422499,0.07396036,-0.07006778,-0.042529203,-0.059066296,-0.020774577,0.0043081134,0.091247484,0.08516147,0.027610779,0.027486084,0.019393697,-0.031764712,0.01766156,0.06578395,0.12419614,-0.0073303934,0.060981516,-0.04059885,0.0066148825,0.00321282,0.034561127,-0.023956262,-0.040840924,0.09230337,-0.009915853,-0.06463724,-0.077380344,0.019040773,-0.016701411,-0.03962098,-0.06490201,0.007104932,0.0372388,-0.0177646,-0.016012074,-0.071805514,0.041906815,0.02651347,0.06742545,-0.020589903,0.07125803,-0.026062923,0.058473904,-0.09824076,0.091959424,0.00049861614,0.005762959,0.038623422,0.05762696,0.021700693,-0.17629755,2.8720097e-33,0.020818379,0.011300167,0.06867051,-0.0137855755,-0.0692124,-0.014669178,-0.057692766,-0.002606512,-0.056154925,-0.0049595884,-0.06802335,-0.02124834,0.035763897,-0.028590972,-0.0529864,-0.025878366,-0.023687396,0.032485746,0.016813274,-0.051836245,0.058076344,0.047788084,-0.020210668,-0.09783764,0.03111213,0.037928283,-0.055677705,-0.025030563,0.09717756,0.007921527,-0.09030778,-0.046898622,-0.07477559,0.043207366,-0.04806241,0.002915198,0.011254464,-0.14546317,-0.0110008335,-0.013481885,-0.000114838986,0.031083869,-0.039307117,-0.07464626,0.056015782,-0.107781984,-0.09814294,0.014348085,-0.016471718,0.008670148,0.05485491,-0.019610547,0.10323377,-0.03364418,-0.08460345,0.031912215,0.018864376,-0.06472652,0.062958896,0.035219286,-0.038004503,-0.038457543,-0.031450108,-0.012978734,0.04438183,-0.019948011,-0.053439587,-0.12873448,-0.007057911,0.007833856,-0.043052927,0.049493484,0.106822886,-0.012512491,0.037126277,-0.06347206,-0.07821865,0.054740794,-0.054638457,0.09839826,-0.018120246,-0.009470158,0.018753637,-0.024044529,-0.012769848,-0.03821067,0.06339996,-0.05027329,0.0011559172,-0.030354366,0.048562862,-0.028001178,-0.0079260245,-0.009461647,-0.029108841,-2.992228e-33,-0.0391665,-0.03865744,0.13176043,-0.01867946,0.0043983324,-0.014060281,-0.008032045,0.0074035437,0.08200063,-0.055647593,0.07981719,-0.016066767,0.019448416,-0.0690393,0.036288925,0.02636276,0.04461814,0.06031987,-0.020706177,-0.0012328874,-0.0967222,-0.04679906,0.016001362,0.044394713,0.016372822,-0.0060068658,-0.0050877105,0.022928083,0.006635481,0.007690459,-0.11815074,0.078369126,-0.02142796,-0.04809725,-0.006558057,-0.032794144,-0.0974636,0.015118656,-0.033703938,-0.04408922,0.03297053,0.06407365,0.030132888,0.096505076,0.027328163,0.126507,0.014181675,0.07346522,0.07532262,0.022695173,0.023621317,-0.04341017,0.031534642,0.0732997,0.047893904,0.021862391,0.047288574,0.020224124,-0.0114490725,0.084653825,0.05244928,0.022449872,-0.009551258,0.004640846,0.061083857,0.056812514,-0.07327509,0.056961965,0.027042534,-0.04555029,0.10099246,0.020942988,0.0042628017,0.002010275,-0.04642921,0.03486103,-0.0056963586,-0.030384226,-0.011823654,0.0029112345,0.016341893,0.049724102,-0.031482603,-0.016305609,0.00788557,0.007309373,-0.008564248,0.117319405,0.01883574,-0.064300634,-0.036642846,-0.034832932,0.02641142,0.046908654,0.057186645,-3.7505036e-08,-0.010321053,-0.03318375,-0.018869046,-0.087390296,-0.048793606,0.04970271,-0.009675059,-0.09994119,0.03011058,0.014634771,0.083412446,-0.01746617,-0.009928513,-0.034524795,0.030938996,0.03277792,-0.02241715,0.035309233,-0.037599213,-0.076638706,-0.025350077,0.041676186,-0.022323824,-0.030656656,-0.054425105,-0.06698555,0.011205327,0.008985892,0.02630882,-0.058507934,-0.07030316,-0.03226492,-0.051457494,-0.0098200105,-0.05009821,0.06720276,0.023036862,0.004185613,0.053517267,0.009056282,-3.714979e-05,-0.049246598,-0.02802856,-0.031977806,-0.040280763,0.005990605,0.04878782,-0.043962892,0.0052861352,-0.059556264,0.011819322,0.08143238,-0.034706753,-0.13696611,-0.0677138,0.06072148,0.0022646424,-0.029825121,-0.023667447,-0.053865083,0.053531464,-0.06655025,0.20162077,0.069933705 +3.4.21.96,"Associated with the cell envelope of Lactococcus lactis and attached via a C-terminal membrane anchor sequence. Responsible for the hydrolysis of casein in milk and the provision of peptides essential to cell growth. Important in cheese making and the production of lactic casein, being required for rapid growth to high cell densities with concomitant production of adequate levels of lactic acid. Specificity differences between lactocepins from different starter strains may be partly responsible for imparting different flavour qualities to cheese [4]. In peptidase family S8 (subtilisin family)",384,1.0,-0.027255084,-0.15822189,-0.045326196,-0.031611845,0.03424915,0.045395102,-0.055496216,0.15036076,0.025386984,-0.015576297,0.027413541,-0.024072785,-0.035652306,0.043774225,-0.07596733,-0.051203437,-0.04151588,-0.0048620817,-0.005240179,-0.084486574,0.08043377,-0.039477948,-0.03236085,0.0060518575,0.007644309,-0.07170143,0.05739503,-0.009604859,-0.016242959,-0.02482315,-0.06326226,-0.070907645,0.0030026368,-0.045506097,0.009652228,0.038811583,0.105035126,-0.093928754,0.11248347,-0.013590686,0.07899563,0.011460998,0.048426505,0.00026883127,0.050826278,0.017923264,-0.017526865,0.091236375,0.04144761,-0.029747276,-0.04566529,-0.07159892,0.0049259216,-0.016316088,0.018250281,0.018780043,0.008245591,-0.06603855,0.103829995,0.024775876,0.0091712335,-0.03627109,0.098596185,0.015845848,-0.020128772,-0.077077955,0.025032684,0.0070655523,-0.07101132,0.0053010867,-0.00039671687,-0.035383083,-0.046613894,0.07557308,-0.013127457,0.10227112,0.0013936223,-0.0838422,-0.023564385,0.023375655,0.0026334138,-0.040595416,-0.031281553,0.14527361,-0.052952666,-0.06925778,0.11018696,-0.06180238,-0.0057292567,-0.0035798291,-0.0037733514,-0.060106568,-0.0047146427,-0.044984,-0.07541832,-0.034058344,-0.019598074,-0.050293453,-0.0010873682,-0.04192157,-0.057131737,-0.04004423,0.04698379,-0.044225324,-0.013968144,0.03318381,-0.025956508,0.058355745,0.07893515,0.002355924,-0.050129373,0.057995886,-0.01711323,-0.040202692,-0.08025036,0.009972722,0.07595282,-0.06733027,0.03383708,0.052948497,0.0050840983,0.048069965,0.047132578,0.062234364,-0.011833738,-0.031018946,0.055275746,1.0242926e-33,-0.01754384,-0.09626625,0.06983884,-0.0068144216,0.0842784,-0.034843907,-0.067615874,-0.017852245,0.009517936,0.016549353,-0.080280535,-0.06477543,-0.028532261,0.0056524547,-0.027878605,0.03294785,0.016930921,-0.058179673,-0.06338281,0.02797002,-0.07786852,0.03640957,0.023205219,-0.025168207,0.1163596,0.0212612,0.04318066,-0.015161009,0.001703964,-0.031892855,0.022930844,-0.071486995,-0.113135025,0.060708683,0.024283683,0.029043693,0.07717955,-0.048619512,0.04216621,0.013779084,0.0023081554,0.029111844,0.037132002,-0.05080732,-0.0069234692,-0.015883952,-0.053944733,-0.019591741,-0.03784467,-0.015310904,0.08419223,-0.022121422,0.0063528833,0.017346404,-0.044733025,-0.040641453,-0.04082936,0.029938063,0.124632195,0.034387507,0.06802706,-0.009264485,-0.010931391,0.043287445,0.020376844,0.013249992,-0.044139057,-0.045898445,0.032452106,0.018303076,-0.022797406,-0.08852257,0.021479199,0.018306265,0.0123711815,-0.008702983,-0.052207023,0.04444102,-0.00069758954,0.021225587,-0.013018042,-0.041957114,-0.029213272,0.019375984,-0.07830974,-0.012493519,-0.091108255,-0.020948902,-0.001633443,-0.012671236,0.0074235816,-0.025015496,-0.033136837,0.05850791,-0.03739109,-3.7699852e-33,0.019974979,-0.098460145,0.050360024,-0.07098789,-0.053750616,-0.020322084,-0.015794817,0.086473726,-0.0038515977,-0.042644866,0.027811497,-0.03877884,-0.06333643,0.00033386186,-0.018343046,0.08801545,0.0029345613,0.06815298,-0.005822425,-1.4559819e-05,-0.01998868,0.06608758,0.030730931,0.04835808,0.055792294,0.03894793,-0.0517339,0.08537348,-0.03931069,-0.007263313,-0.036726736,-0.011465959,-0.027769754,-0.04189932,-0.079520755,0.0037080697,-0.010388408,6.144076e-06,0.06913415,-0.017362224,-0.00080641545,0.05089083,0.014985214,0.086270526,-0.0011794129,0.04035213,0.04254996,-0.030759629,0.055616662,-0.023064388,0.01350502,-0.051070616,0.06597929,-0.0080779055,0.009281755,0.059685547,0.039637145,0.010404515,0.026878852,-0.0131244045,0.022467418,0.005187181,0.03518375,-0.109448135,0.003993857,0.019644614,-0.13376763,-0.09188128,0.07694246,-0.0546081,0.010047506,0.038951572,0.043336295,0.054326396,-0.054192215,0.018307673,-0.06447032,-0.06827053,0.017349362,0.014467127,-0.084430635,-0.009311962,-0.04296267,0.072104424,0.041995928,-0.0017232839,0.04435143,0.027743993,-0.0009127009,0.0186036,0.0023702215,-0.025986372,-0.023110723,0.07444711,0.022207929,-3.6241424e-08,0.110143,-0.0625919,0.02523253,-0.027561614,-0.03143928,-0.037687827,-0.08118384,-0.030688953,0.06637854,-0.07361226,-0.051228605,0.16058391,-0.086636536,0.0504617,-0.025910748,0.09255939,-0.053973902,-0.0043358826,0.0022093775,0.1006534,-0.06275379,-0.021579543,-0.061238423,0.016715571,0.030806415,-0.0691473,0.017985603,0.06691376,-0.013648477,-0.039031655,0.08001698,0.06005854,-0.047981266,-0.00653498,0.038612626,0.06842187,-0.1436175,-0.042034,0.0064744763,-0.025615714,0.031907655,-0.021271339,0.0018101879,-0.028301096,-0.0505119,-0.0024668803,-0.020616135,0.07043052,-0.011863156,0.029808898,0.027090784,-0.052878834,-0.019658642,0.005424165,0.011409186,0.003434996,0.05313906,-0.055359457,0.053944927,-0.0016204047,0.031630766,0.0025082454,0.1638645,0.017165666 +3.4.21.97,"Involved in the breakdown of the scaffold protein during the late stages of assembly of the herpes-virus virion. Inhibited by diisopropyl fluorophosphate. Type example of peptidase family S21. Catalytic residues are His, Ser, His, a combination not known for any other peptidase, and the protein fold also is unique. Known from herpes viruses of several types, cytomegalovirus, Epstein-Barr virus and human herpesvirus 3",384,1.0,-0.0709766,-0.08701807,-0.079033785,-0.07285361,0.082308404,0.08518083,0.0051541887,0.12710628,0.03600802,0.06753239,0.021884542,0.057574965,0.028147861,0.07022247,-0.029454576,-0.068597116,-0.12273994,-0.03989505,-0.0026156364,-0.0463028,0.06707457,0.029790528,0.0033673525,0.0129465815,-0.028708203,0.043817017,-0.033659488,0.018497173,0.07149114,0.0034241974,0.028593753,-0.062396165,0.07107253,-0.0017963059,0.06156274,0.06014719,-0.034215197,0.028665038,0.015623999,0.0060359356,0.024491085,0.053325478,0.009173801,-0.0369575,0.05880906,-0.0063936207,-0.023804238,0.04800961,0.03849041,-0.04742862,0.021322249,-0.05067796,-0.0020596809,-0.030299516,-0.016020196,0.03177778,-0.074135974,-0.04515229,0.030306779,0.051395368,0.022672247,0.016676528,0.017508384,-0.054028068,0.050498225,-0.07601281,0.03332564,0.016187787,0.05241442,0.06574018,-0.058974754,-0.00471817,-0.07868269,0.10211585,0.0075503346,0.10063025,0.029847298,-0.034033474,-0.06466155,-0.0304113,-0.041423846,-0.045681104,0.11780102,0.056893975,-0.008253001,-0.002585806,0.009194449,-0.05076183,0.08909035,0.0037386918,0.0101308925,-0.08822125,0.01499261,0.025419584,-0.03964422,0.008093886,0.05974476,0.009971569,0.044369284,0.006519642,0.010282531,-0.019089641,0.02006407,-0.023178464,0.022131352,0.047056045,-0.03736361,0.021220632,0.006214143,0.0063641462,0.033100672,0.011250351,0.036211655,-0.067754366,0.01236415,0.05420568,-0.079657376,-0.05368661,-0.0145120425,-0.016317956,0.030471612,-0.013333937,0.07502548,0.04732685,-0.13547513,-0.0014740812,-0.038393896,2.5099752e-33,-0.027469624,0.03327658,0.021499543,0.07846899,-0.021395452,0.026917927,-0.011568711,0.023113709,-0.01830394,-0.02584605,-0.07983779,0.0006562731,0.029263472,0.003970948,-0.12528487,-0.035304178,0.011146005,-0.0010200562,-0.030377224,-0.013250243,0.069426894,0.0924806,0.04481788,-0.033781253,0.12485467,-0.07255413,-0.024557631,0.0028585226,0.05340897,0.0007420421,-0.05370454,0.01236062,-0.09783973,0.0087399315,-0.033475086,-0.01623059,-0.016207986,-0.065371364,-0.022143958,0.0470718,0.10263888,-0.03921344,-0.022398598,-0.007016339,0.030728886,-0.027523512,0.023164501,0.05851765,-0.09710643,-0.013404363,-0.00073293824,0.044841453,0.03071309,-0.024962436,-0.09200925,0.03807885,0.0417503,-0.045672994,0.08793917,0.05859864,0.049968686,0.048314165,-0.042716764,0.06996195,0.01079151,-0.06092686,0.014762874,-0.014255243,-0.03570852,0.1097863,-0.053645417,0.08813638,0.040205427,-0.013970284,0.013385241,-0.07668214,-0.09615091,0.045722872,-0.044070385,0.0664857,-0.0053237,0.003140724,-0.027978245,-0.041904956,-0.06739921,-0.04567579,0.012608449,-0.05764806,-0.07821959,-0.016634056,-0.010551809,-0.08678614,0.06895826,0.02479316,-0.025204916,-4.1662106e-33,0.022309644,-0.04335464,0.05039861,-0.053766944,-0.028312638,0.07203354,0.113864884,-0.013019294,-0.008996424,-0.048622645,0.012719257,-0.07383539,0.026973998,-0.10291638,-0.03611891,-0.0011425962,-0.01391529,0.055337097,-0.02026059,0.015130152,-0.0924954,-0.0014314065,0.026164187,0.06485444,-0.020789186,0.001795116,0.016985446,0.050411277,-0.033936985,0.039165713,0.013826391,0.017477755,0.0015210696,-0.0044563096,-0.09548154,0.014230425,-0.093638815,-0.063895,0.07239313,-0.12864146,0.064850345,0.08615142,0.042118214,0.06645475,0.009088435,0.09423998,-0.09298299,0.07455614,0.034627832,-0.05436944,-0.0011930537,-0.04628667,-0.019971807,0.031132013,0.05551598,-0.010095899,-0.038830962,0.023884632,-0.033180315,0.09884707,0.05134468,-0.033141542,-0.029487759,0.03300191,0.08373493,-0.022624156,-0.07458994,-0.0055126664,0.07705398,-0.042547878,0.059231985,-0.010453071,0.03163223,0.00055068923,0.024097212,0.06202129,-0.03256227,-0.035170883,0.0005592055,-0.0769012,0.0055532954,-0.06350918,-0.003993992,0.014922531,0.016387729,-0.043738067,-0.018189441,0.06760468,0.032095358,-0.0005328012,0.007948341,-0.060421627,0.082588434,0.073133335,0.0601086,-3.7408928e-08,0.12219168,-0.048121616,0.04581096,-0.041020963,-0.07445303,0.005953568,-0.018113412,-0.038404513,0.042722657,-0.013083185,-0.018148262,-0.031178398,-0.025141193,-0.006617655,-0.019537365,0.038036548,-0.113889664,0.14159593,-0.026462996,-0.03324984,-0.04283678,-0.021142332,-0.023935312,0.028210005,-0.0012995214,-0.008199722,0.02083992,0.0526326,-0.0006168213,-0.09523042,-0.036173545,-0.052046366,-0.06155103,0.008991295,-0.011419588,0.04162199,-0.009419113,-0.028353903,0.047151998,0.004402868,0.097981595,-0.059521213,-0.054746334,-0.050160546,-0.04534753,0.027901735,-0.063108325,0.03832537,-0.0013489283,0.011917403,-0.05458939,0.032464273,-0.040135745,-0.053799514,-0.09564107,-0.0016679289,-0.019356769,-0.019688642,0.05782063,-0.08221646,-0.00087133143,-0.07097991,0.10279829,0.033141464 +3.4.21.98,"Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins. The enzyme is greatly activated by binding of the 54-residue NS4A 'cofactor' protein also derived from the viral polyprotein. Type example of peptidase family S29. The crystallographic structure shows a chymotrypsin-like fold.",384,1.0,-0.036163952,-0.047474816,-0.1258403,-0.09319274,0.040002078,0.11653826,-0.06795461,0.08906038,0.0075621,0.041649126,0.011001794,-0.03990749,-0.0032935368,0.07154036,-0.043457452,-0.0066304426,-0.14990135,-0.022194285,0.0386541,-0.09765707,0.0012862602,-0.012289178,-0.032339294,-0.027264783,-0.04133053,0.06619631,0.029947503,-0.01863677,0.047624506,-0.026020626,0.010914426,-0.009812494,0.07219843,-0.028195083,0.043763634,0.045035753,0.021776106,0.043193717,0.015267554,-0.0002560392,0.050122637,0.118119635,0.03840927,0.011364362,0.0300241,0.019648721,0.017469207,0.08968402,0.07472681,-0.021941237,0.008715112,-0.045334395,0.022444468,-0.021672525,0.0049798605,0.03256201,-0.024127306,-0.076054655,0.058396604,-0.007905248,0.0025767158,-0.00838935,0.040344566,-0.014298502,0.04226145,-0.04739857,0.05687517,-0.02880582,-0.01992902,-0.019626306,-0.07665244,0.01575496,-0.05684546,0.10686841,-0.045089014,0.033509985,0.0014431134,-0.072673574,0.02061902,-0.010981275,-0.060146444,0.045797907,0.11415255,0.11116399,-0.026150957,0.01593937,0.014998313,-0.06430113,0.0155174825,-0.014679684,0.005877214,-0.0937036,0.008457139,-0.038457148,-0.073439404,0.024162784,0.06691059,-0.017066875,0.038449,-0.012179369,0.04833981,-0.027223513,0.021581793,-0.019776957,0.011121468,0.03340213,-0.045390666,0.092761226,0.029819056,0.02781155,-0.038411207,0.06821512,-0.0006481517,-0.090532295,-0.007560409,0.07403636,-0.049391963,-0.019192696,-2.5888947e-05,-0.0026707118,0.013577049,0.031469613,0.061128866,0.054933503,-0.039420005,-0.07616308,-0.0714786,3.947617e-35,0.0056414916,0.022560934,0.08362715,0.06387054,0.009660545,-0.059484657,0.021725237,0.031655747,-0.016540164,-0.032775864,-0.08350417,-0.021525195,0.024817789,0.033858486,-0.09677826,-0.004746959,-0.061810076,-0.028709356,-0.045607254,0.011065094,-0.02454805,0.1037521,0.067652665,-0.012381669,0.116437666,-0.02402332,-0.0064054886,0.01998652,0.04298496,-0.0053322082,-0.050484136,0.0654373,-0.12436233,-0.020284748,0.008105557,0.03236412,0.04082786,-0.068509385,-0.003027406,0.11183636,0.12032119,0.0011908916,-0.0057947966,-0.08827071,0.04755022,-0.06330998,-0.053525522,-0.0010750064,-0.099193014,0.0025717954,0.02631836,-0.0033094203,0.0035051943,-0.0058901752,-0.06233576,-0.01593224,-0.02803975,-0.09443325,0.03471976,0.016714,0.10400447,-0.007061764,-0.041030016,0.07062416,-0.0034822295,-0.031660505,-0.005970084,-0.061159007,0.0317281,0.1243285,-0.020346552,0.052113663,0.05507159,0.0015710881,0.022541096,-0.054197844,-0.09297117,-0.00043249194,-0.020527689,0.01863513,-0.023520414,0.0016236729,-0.00025422822,-0.06449164,-0.020084877,-0.08417115,0.027355114,-0.055185005,-0.1307867,-0.0032540201,-0.01901899,-0.042773094,0.037652254,0.06399176,-0.015521351,-2.5145835e-33,0.026297405,-0.09013136,0.029555075,-0.05053507,-0.056237515,0.063615754,0.050339244,0.0064058164,-0.013587188,-0.049923908,0.062161103,-0.061690263,0.022188084,-0.057375245,0.031862397,0.0035224832,0.040724866,0.119715236,-0.051992532,-0.0027417745,-0.049426205,-0.03332342,0.010562999,-0.014109647,0.04246877,-0.026719416,-0.049593028,0.00951976,0.014834855,0.05988566,-0.11457777,0.019933077,-0.05923035,0.038361095,-0.06283238,0.015191456,-0.058616214,-0.018203622,0.06384557,-0.057218064,0.023050778,0.116261646,-0.019604621,0.1107616,0.0063688103,0.086160325,-0.03213084,0.10029525,0.07964922,-0.06947391,0.0042875544,-0.10042414,0.036589038,0.055824894,-0.029638672,0.056353446,0.00461057,0.026542926,0.020923039,0.036954015,-0.03200952,-0.017242992,-0.061562154,0.028279303,0.04871336,0.005393355,-0.057321202,-0.0068048458,0.046322465,-0.086165264,0.0114406105,-0.027783435,0.050216977,0.07315891,-0.012888687,-0.01599161,-0.03284324,-0.027099825,-0.045914523,-0.06870405,-0.0045758635,-0.034181736,0.01721038,0.016851302,0.056544825,-0.006598162,0.0072542503,0.026264701,0.060458537,0.0672084,0.0067864065,0.019632231,0.008468161,0.05561446,0.016427208,-4.0552916e-08,0.07100219,-0.03445151,0.022185989,-0.047399152,-0.0741197,0.085692085,-0.045142747,-0.057875473,0.05031061,-0.04986543,0.019093905,0.047357097,-0.040867824,0.022312248,0.016578447,0.0760975,-0.10351966,0.077998035,0.019154694,0.040027767,-0.084656194,-0.03197648,-0.044463594,0.048952337,-0.022864262,-0.022496292,-0.03889005,0.025580196,0.022876568,-0.018269805,-0.020373907,0.008580349,-0.008105946,-0.044066843,-0.016214319,0.019719575,0.008337459,-0.060817987,0.021322083,-0.015724394,0.10441398,-0.04417632,-0.06545465,-0.066399075,0.0064794314,-0.0070262775,-0.027891055,0.043153822,-0.037542786,0.013812048,-0.018658152,0.032681774,-0.0013411272,-0.06106399,-0.060825057,-0.007954128,-0.0122821955,-0.0775959,0.063498616,-0.10907484,-0.018873377,-0.002155467,0.099716015,0.032749966 +3.4.21.99,"The enzyme from the ascidian (Prochordate) Halocynthia roretzi is localized in the sperm head, and released during sperm activation. A proline-rich region is involved in binding to the vitelline coat of the egg. Belongs in peptidase family S1 (trypsin family).",384,0.99999994,-0.031042034,0.008229349,-0.14429165,-0.018740922,0.059623316,0.06371131,0.029414192,0.047586918,0.03929796,-0.008275744,0.09540065,-0.06539148,-0.047079954,0.018704385,-0.069884636,-0.011754797,0.010628424,-0.08874593,-0.0008717632,-0.0029837156,0.058323957,0.027281653,-0.02185972,0.0030776311,0.026885968,-0.010195695,0.043225452,0.034782305,0.0011946218,-0.07540036,-0.032100145,-0.018029474,0.055745766,-0.026216615,0.074656166,0.089137636,-0.010743044,-0.018005352,0.06890685,-0.00019305188,0.054896343,-0.0059686275,-0.045934726,0.0028355988,0.029564712,0.06306843,0.07364893,0.06552099,0.075326964,0.0017114715,-0.04976543,-0.10852934,0.020832045,0.055649936,-0.018616686,0.081846066,0.004564325,-0.103180654,-0.0025122822,0.031406373,-0.03947859,0.034532327,-0.02262317,-0.03654945,0.06529832,-0.045087177,-0.007446305,0.034643184,-0.03559917,-0.022802647,0.032991223,-0.011237513,-0.026852822,0.10124386,0.026076553,0.038080573,-0.040250577,-0.056422196,0.0014605398,-0.06013232,-0.033252303,-0.05850182,0.047760632,0.06393142,-0.020873914,0.009197383,0.07691382,-0.019669907,0.01577606,0.025850082,-0.035241,-0.043715693,0.0076121953,-0.02107315,-0.03526402,-0.008800819,0.017837089,-0.07368198,0.022047147,-0.008954669,0.0035179863,-0.026193947,0.017698595,-0.09969451,-0.0773586,0.021406682,-0.06443477,0.024633767,0.054710537,-0.005003249,-0.0038106267,-0.076253384,0.03888938,-0.025606573,0.035546545,0.023654118,-0.060464818,0.04344392,-0.052090738,-0.0004702355,0.009109075,0.03784713,-0.027498879,0.029877737,0.031639088,0.012954132,-0.07684261,1.4947922e-33,0.08138185,-0.029182283,0.009522039,0.08537721,-0.05192315,0.0979729,0.027288174,-0.04223247,-0.0677935,-0.12847307,-0.0696499,-0.07475968,-0.029762076,-0.018771581,-0.014257959,-0.005702746,-0.06248445,-0.032021545,-0.023496395,0.060926024,-0.018581146,0.07139089,-0.054865383,-0.07182797,-0.0022101246,-0.01872785,-0.063031256,-0.008029906,-0.006158282,0.0056145494,0.05487796,-0.006325657,-0.095854074,0.02730167,0.04988345,0.09749248,0.042369388,-0.13749854,-0.087688774,0.032255966,0.010500199,-0.022362523,-0.02587892,0.012076779,-0.021213291,-0.08370449,-0.05445417,0.0657274,0.06128849,0.012840457,-0.00070952345,-0.016300956,0.12129725,-0.073992625,-0.06771276,0.0855715,-0.040140163,0.007775692,0.021739382,0.05358414,0.0603032,-0.017472012,-0.03726023,0.06322578,0.035045844,0.034765743,-0.033137176,-0.043484654,-0.006455433,0.023044875,-0.07444172,0.010810544,0.12171518,-0.024368843,-0.057031967,-0.0154306935,-0.088789575,0.02116391,0.014302232,-0.031211283,0.031217877,0.014240259,-0.03935049,-0.02251528,-0.057616133,0.018305741,0.073214926,-0.03127433,-0.027216384,-0.013736846,0.06754037,-0.04091183,0.02212605,-0.029773708,0.03417837,-2.7571633e-33,0.051634658,-0.1369106,0.06621176,0.008522118,0.0011357109,0.11162814,0.09139791,-0.033110827,-0.1007394,-0.035226196,0.03818802,-0.043775726,0.034854684,-0.05152178,0.014640888,0.0046432535,0.023919458,0.095596395,0.06657934,-0.067015685,-0.052032594,0.03676722,0.058609325,0.05192006,0.021304604,-0.04221384,0.0255706,0.04661716,-0.029561603,0.05308351,-0.014484744,0.08495271,-0.0702097,-0.038228557,-0.053861927,0.062340677,-0.05290673,0.0036539878,0.045555476,-0.03856058,-0.085560605,0.032573797,0.0048043802,0.012396384,0.0006122526,0.09665486,0.014077194,0.10171093,0.033690613,-0.010079929,-0.0043384023,-0.080244616,-0.03499805,0.011364325,0.027025646,0.028090298,-0.049238287,-0.0016799862,0.088592164,-0.0006349064,-0.04837213,-0.013668272,-0.015813464,0.10680709,0.016289338,0.026022397,-0.018853607,-0.013280924,0.12808333,-0.013982081,0.06960174,0.0002799783,0.08638016,0.0029161365,-0.03665908,0.006546044,-0.06162102,-0.011290169,-0.038908586,-0.016098069,-0.01087879,-0.047929816,-0.02146901,0.040449195,-0.0136228595,-0.09220919,0.022077389,0.044476222,0.008162607,0.013844289,-0.084675066,0.06564276,-0.0033985125,0.014216117,0.08182735,-3.7694566e-08,0.094344534,-0.046792746,0.077163935,-0.06437694,0.019171352,0.005771656,-0.00059689936,-0.032874614,0.061589494,-0.038671106,-0.10907533,-0.01547361,0.018310243,-0.05624205,0.02068832,0.08702004,0.07778682,0.114622064,-0.034174018,0.0036034686,-0.0030925306,-0.0321703,-0.04282657,0.045811653,-0.028839728,0.0539141,0.017562378,0.06810177,0.015216275,-0.07676485,0.033106077,-0.014172333,-0.005595296,-0.08729356,-0.042338733,0.06935304,-0.054010328,0.028248137,0.006787629,0.01256439,0.053111866,-0.08043242,0.010994587,-0.024395313,-0.047725365,0.031793293,0.055247128,0.0035989485,-0.02697488,0.004181723,-0.054451007,-0.0051654186,-0.031251032,0.020646848,-0.032205947,0.041997753,0.03560318,-0.07012061,-0.016953059,0.0038141268,-0.059088852,0.09074759,0.14663316,-0.023097929 +3.4.21.100,"An enzyme secreted by Pseudomonas sp. No. 101. Optimum pH is 4. It is distinguished from xanthomonapepsin by its insensitivity to EPNP and from scytalidopepsin B by this property and by its unrelated amino-acid sequence. Inhibited by tyrostatin, a peptide aldehyde [2]. Type example of peptidase family S53.",384,0.99999994,-0.032055978,-0.056174133,-0.088804595,-0.045528624,0.07230002,0.12291864,-0.021845194,0.09513061,0.011081389,0.0098532485,0.06890993,-0.052789573,0.01600359,0.08749838,-0.060072526,0.015222126,-0.077850245,-0.03181472,0.009290923,-0.026978076,0.023360176,0.07817593,0.0044976682,0.050870102,0.0066446513,0.009806975,0.056541387,0.013938975,0.0045132255,-0.021242015,-0.026975483,-0.03809,0.07660259,-0.05522792,0.08432686,0.053411476,-0.033613604,0.003168571,0.064432874,-0.001263816,0.053796742,-0.019248558,-0.04031892,-0.052162133,-0.007862847,-0.0007988958,-0.019156275,0.06275382,0.0115469955,-0.039203703,-0.07045177,-0.031123802,3.324656e-05,0.03691848,-0.040449057,-0.017681492,0.008609683,-0.029938662,0.002776573,-0.008064642,0.038124297,-0.026553093,0.065420866,-0.05340968,0.060758132,-0.022645926,0.015577446,-0.06205742,0.04350091,0.026055953,-0.051046547,-0.01044815,-0.00041585346,0.071157634,0.056062315,-0.010083816,-0.024583705,-0.0720328,-0.075803734,-0.053110972,-0.0026331104,-0.011046044,-0.020055424,0.1429568,0.038451318,-0.073975675,-0.004399506,0.04098045,0.04450803,-0.026279198,0.010646057,-0.060960192,-0.0014959619,-0.06479668,-0.062919654,0.018514538,-0.035557583,-0.04324748,-0.023468982,-0.003924456,0.041074015,-0.047204155,-0.04712164,-0.03681439,0.02762123,0.047662884,-0.027301004,0.05528066,0.050699692,-0.009824706,-0.0007789661,-0.029506119,0.043209434,-0.054047808,0.020892158,0.06556384,0.042367473,-0.023742935,-0.0059100003,0.048980024,0.03339329,-0.029894855,0.079227194,0.060537633,-0.0153175965,0.015708407,-0.11722635,3.2517557e-33,0.06682184,0.00064322504,0.025071688,-0.0165743,0.043097656,-0.017679887,-0.027850825,0.02251874,0.03237922,-0.051766492,-0.0763396,-0.08647356,-0.050833315,-0.0329457,-0.060289513,0.015678586,-0.10659436,0.03725625,0.015399485,0.032742426,0.02386137,0.038676206,-0.029499076,-0.041268937,0.10767999,0.021371506,-0.0064389426,-0.042692933,0.060995862,0.0051015336,-0.012709764,-0.019684952,-0.12539555,-0.007367254,0.003442304,0.002969049,0.006105313,-0.042379864,0.034085546,0.04962138,0.018998498,0.0630858,0.070182696,-0.026019184,0.0978212,0.022862744,-0.08943329,0.05492547,-0.014454266,0.03639375,0.058390256,-0.09905972,0.01926943,0.03233098,-0.05223371,-0.038287904,-0.05275135,0.035488497,0.041661106,0.072908595,0.040316537,-0.00453422,-0.031660285,0.02373335,-0.054565813,-0.027091997,-0.016962525,-0.06584173,0.025257882,0.06644495,-0.07579034,0.030966723,0.086048044,0.017253714,-0.019551571,-0.13415134,-0.009677631,0.09249757,-0.00019391767,0.04695396,-0.00074576604,-0.01531207,-0.0085658515,-0.02783612,-0.11328686,-0.04093755,0.031234356,-0.01379741,-0.05415448,-0.018890802,0.03438335,-0.07168765,-0.029484551,0.07061438,-0.058344614,-3.4161166e-33,-0.017653806,-0.04751689,0.12009008,0.034525305,-0.034171488,0.023624402,-0.0033408424,0.072417445,-0.023172244,-0.04583134,0.09507118,0.011999377,0.052170042,-0.053750977,0.051116385,0.07681041,0.051970303,0.027736077,0.012860191,-0.02227042,-0.10553296,0.034481257,-0.04989913,0.09337622,0.089072265,0.044612367,-0.074265674,0.053408876,0.042691845,0.039625004,-0.09659356,0.10572499,-0.0850561,-0.04530598,-0.045848273,-0.028976992,-0.08072833,0.042005263,-0.027581925,0.034699988,0.088900305,0.06538927,0.017203681,0.15450868,-0.05043429,0.07734704,-0.022604056,-0.02498438,0.07699343,-0.049804512,-0.024236837,-0.043505434,-0.032966986,0.022657238,0.0013847223,0.020371467,-0.02443612,0.06669704,-0.050314955,0.041083947,-0.0024548646,-0.050948463,-0.05935983,0.016522093,0.014376568,0.022075837,-0.0671569,0.010852008,0.08491174,-0.044622585,0.03250507,-0.069091715,0.0636593,0.021348644,-0.07234583,0.011369584,-0.074707046,-0.05214214,-0.017858967,-0.006135176,0.02278995,-0.016663406,-0.00030733328,-0.03991423,0.0022267122,-0.046207994,0.08109889,0.07727971,-0.07193467,-0.009933993,0.0023137943,-2.4161114e-05,0.033523828,0.00090895745,0.015347359,-4.0154525e-08,0.12285556,-0.061124746,0.06239208,-0.03126879,-0.016658094,0.0101104425,-0.017251408,0.0055078957,0.054468878,-0.026623052,-0.037210956,-0.0069983867,-0.021420036,0.040807027,0.013486148,0.00071205734,-0.06083633,0.07543957,-0.04656848,-0.019697398,-0.10206021,0.010680907,-0.119642735,-0.025598248,-0.03129371,0.003693182,0.038781337,0.050239004,0.058681455,0.011919624,-0.06362779,-0.020854482,-0.025085174,0.054967664,-0.044944454,0.06685363,-0.022634279,-0.0661875,-0.027692085,-0.05364782,0.03055573,-0.05987005,-0.08038508,-0.049095478,-0.015203934,-0.010048184,0.105208695,-0.030391349,-0.009310658,-0.008791743,0.055277687,-0.017252859,0.039885096,-0.0497578,-0.04614913,0.060808174,-0.006590403,-0.051848844,-0.03283655,-0.09196945,0.027228344,0.021706564,0.15375513,0.070455685 +3.4.21.101,Secreted by the bacterium Xanthomonas sp. Belongs in peptidase family S53.,384,1.0,-0.05774519,-0.0144758625,-0.06319754,-0.01732193,0.07338698,0.030999424,0.0019302699,0.021449745,0.040374335,0.02395273,0.09011093,-0.10311012,0.0674194,-0.017009938,-0.030213581,-0.010016586,-0.12157721,-0.082150474,-0.01647415,-0.0043518087,0.053114243,0.0867214,0.044789232,0.021771092,-0.03469032,0.058381923,0.020637933,-0.0153134,-0.0015210987,-0.080472134,0.017158777,-0.023286194,0.077802405,-0.02133558,0.07281856,0.048418988,0.01349179,0.010209043,0.102814496,-0.023811214,0.024307804,-0.045054503,0.017000945,-0.0010477112,-0.029808275,0.04146405,-0.034417458,0.0952625,0.016509894,0.029300595,-0.033023797,-0.06037358,-0.013464518,0.026680984,0.02780596,-0.0019159344,-0.0045697927,-0.07239324,-0.0038170707,-0.0078046354,0.11269334,0.053448807,0.03379994,-0.025015624,-0.031123498,-0.07760616,0.045662053,-0.03026826,0.0667936,-0.0016861466,0.011840406,-0.009553285,-0.02677369,0.058597997,0.014377202,0.007515989,0.02642965,-0.08185515,-0.05826781,-0.043079466,-0.05766258,0.034641884,0.06780191,0.09356722,0.0074304063,-0.06432401,0.0044789817,0.06700172,-0.015587206,-0.012604921,-0.016595544,-0.042412695,0.03477682,-0.05765685,-0.075666964,-0.008389304,0.03985192,-0.020106565,-0.0059661446,0.0004371379,-0.001407987,-0.058778524,-0.035302673,0.0069409,-0.017218713,0.022285607,-0.08948857,0.075739995,0.0034872545,-0.027569294,-0.016014839,-0.015936945,0.0038697622,-0.0051311394,-0.022130404,0.062119238,0.017930115,0.026867142,-0.04207103,0.021741824,-0.026364027,0.008169751,-0.0061130244,0.014209043,-0.03460462,-0.017457627,-0.12002623,4.593384e-35,-0.0070011616,-0.0015048146,0.014366689,0.025340218,-0.0072931848,0.008613324,0.042880096,0.041296232,0.013168949,0.0028149511,-0.08012881,-0.094402045,-0.047923684,-0.051747452,-0.085848734,0.037394673,-0.13272305,0.03856099,-0.046148766,0.03784119,0.028547384,0.05170552,0.015398622,-0.11303713,0.055814408,0.017370438,0.04236308,-0.07108978,0.075814016,0.005077819,-0.060529087,-0.036084123,-0.05709801,-0.003837079,0.006513187,0.06717619,0.033207968,-0.059100725,-0.032771144,0.07823504,0.03194657,0.036515377,0.0024136736,-0.037193168,0.032796003,0.022827445,-0.05273184,-0.05690609,0.015238239,0.022980431,0.08186688,-0.082400575,0.032545738,0.015735632,-0.032142345,0.0042560403,-0.044957552,0.061841115,0.012459296,0.019875675,0.07855193,0.015353661,-0.00218263,0.050025623,0.020872183,0.007900103,0.008567338,-0.038793266,0.00053129066,0.050099883,-0.092801474,-0.056411356,0.11682172,-0.024578026,0.010228655,-0.069516,-0.060827926,0.07045082,0.02061228,0.032964967,0.046579164,-0.031568073,0.042592295,-0.00888254,-0.07997474,-0.007668791,0.026953347,0.015538497,-0.06663316,0.057807982,0.07892428,-0.08751943,-0.017301721,0.023991616,-0.087496944,-1.51053715e-33,-0.011628374,-0.0052352557,0.10351625,0.0012976989,-0.03467449,0.05122247,-0.024975201,0.038770754,-0.07159065,-0.03157744,0.04652424,0.07797413,0.03210733,-0.045006417,0.04202416,0.08122541,0.13953017,0.041468434,-0.046819147,-0.028667407,-0.13793305,0.019040892,-0.07254913,0.008615418,0.01087071,0.023505194,0.015875058,0.054020897,0.074327685,-0.049853984,-0.06994843,0.049754605,-0.03419344,-0.057447363,-0.030757934,-0.07583368,-0.06793461,0.026534783,-0.028449453,-0.04855548,0.023988776,0.044268254,-0.010757433,0.22222628,-0.023476824,0.07459363,-0.010002885,-0.012743663,0.07879288,0.013637194,0.0105491895,-0.077472806,-0.044231582,-0.038627934,-0.009252598,0.017815204,-0.021836946,0.064913794,0.035181902,0.049876057,0.0039257957,-0.016463509,-0.041576654,0.037726328,0.07575251,0.048945464,-0.07719091,0.016292145,0.054357473,0.011132967,0.046406846,-0.07309795,-0.015256017,-0.024336986,-0.0036664512,0.055695415,-0.108584486,-0.09676903,-0.021049174,-0.006000118,0.05186751,-0.09820832,0.032205038,-0.011094282,0.054104,-0.07210975,0.090296976,0.047136523,-0.038434397,-0.03193082,-0.031524606,-0.013824412,0.022011619,0.007171327,0.07630539,-2.169142e-08,0.09735127,-0.06971239,0.03477064,-0.020947888,-0.017680196,0.02726284,-0.035604917,0.0373656,0.09530893,0.0071409647,-0.013399836,-0.06440593,0.011445716,0.041559014,0.017947052,0.007907307,-0.0062270244,0.053037517,-0.035091687,-0.004507916,-0.111693196,0.00022780869,-0.049848218,-0.05195783,0.0036840022,-0.052330595,0.07954459,0.036533587,0.053343542,-0.04373162,-0.09149336,-0.024702555,-0.031943016,0.09507003,-0.02029348,0.039121095,-0.01859849,-0.08516553,0.05457651,-0.04633163,0.052652173,-0.012446331,-0.07061658,-0.0065278225,-0.023962688,0.013068359,0.07553945,-0.0110306805,-0.051119808,-0.010698881,-0.017854625,-0.024438707,0.006058338,-0.05700962,-0.07353676,0.07593944,-0.009700002,-0.03990317,0.025842065,-0.059356615,-0.012221014,-0.025201846,0.14510502,0.010943423 +3.4.21.102,"Proteolytic processing of the D1 protein of photosystem II is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation. The recognition of the substrate is mediated by a PDZ domain, a small protein module that promotes protein-protein interactions by binding to internal or C-terminal sequences of their partner proteins. Type example of peptidase family S41.",384,0.99999994,-0.12196466,-0.04374611,-0.08951501,-0.0035126836,0.12483682,-0.030358773,0.008667845,0.11439628,0.0046175383,0.028291719,0.06665212,-0.009784379,0.060218744,0.008755126,0.023071375,0.033500966,-0.12016708,-0.022279147,0.022517608,-0.07993995,0.011245941,-0.022850683,-0.009713486,-0.06740594,-0.026777325,0.045787506,0.004636649,0.0135659585,0.0032095967,-0.031306077,0.0056317635,-0.053154167,0.008213308,-0.016606163,0.10644476,0.07436757,0.010742712,-0.089690074,-0.098463014,-0.052270666,0.071918525,0.03653381,0.02989674,-0.0688344,-0.0398328,-0.025511859,0.04452543,0.05606653,-0.015309755,-0.012652227,0.013467162,-0.07574531,0.00022468362,0.028293042,-0.021628132,0.042465147,0.03712681,0.02955851,0.023838291,-0.06566504,0.019781215,-0.010299369,-0.014170128,-0.045759413,0.11514912,-0.0776251,-0.014386842,-0.032565627,0.0024725422,-0.07323421,-0.052266512,0.04306054,-0.020056026,0.10946513,-0.06805182,0.043060265,0.028861031,-0.0775338,-0.019820526,-0.030931015,0.027557824,0.03924787,0.09539074,0.0739397,0.06341558,0.049280927,-0.008842596,-0.04828983,0.015821917,-0.03643416,-0.01466373,-0.06418218,-0.05298069,0.043139327,-0.10253579,0.031236403,0.026474373,-0.03292329,-0.0061747055,-0.007582003,0.018949,0.032817215,-0.050593827,-0.09155515,0.058566924,0.017559404,-0.0234995,0.11756163,-0.03733126,-0.022669628,0.049218692,0.03695369,0.035088982,0.024885762,0.0067358296,0.015959011,0.051113885,-0.008350524,-0.019312173,-0.06350128,0.000416875,0.04632335,-0.045523424,-0.027776469,-0.008766923,-0.016430786,-0.073338,2.2408003e-34,0.044185147,-0.040367648,0.014453416,0.06314264,-0.024206586,-0.034160856,-0.066828825,-0.04948119,-0.00784862,-0.04910958,-0.12733936,-0.038029082,0.04041701,-0.031496406,-0.049347635,-0.06939715,-0.0062866956,-0.0070926086,0.034988713,0.0953975,-0.031567566,0.11216732,-0.021456808,-0.012377536,0.06703085,0.07460252,0.042873878,-0.0678714,0.05015828,-0.013573451,-0.054168005,-0.025097094,-0.08335847,0.05683671,0.1144682,-0.0366712,0.046563912,-0.03485108,-0.029707862,-0.032432817,-0.017568229,0.0045348597,-0.10758264,0.02086854,0.022261946,-0.0095704645,-0.009798846,0.042118963,-0.014488756,-0.05028422,0.047113128,-0.00985384,0.05665673,0.02097651,-0.0928313,-0.023571568,-0.015515806,-0.079241194,0.09831105,0.07254547,0.017351704,0.017377725,-0.035591315,0.08589385,0.040131975,0.021760995,-0.049188085,0.0012179707,0.010397813,0.06602535,-0.073038474,0.0015146828,0.11239135,-0.018631093,0.06397464,-0.058410875,0.025697514,-0.0079103615,-0.0107015595,0.09333328,0.009204782,-0.019272445,-0.061602313,-0.05076423,-0.112593785,-0.012712618,0.009643496,-0.033566035,-0.06686169,0.024240788,0.0788077,0.010948565,0.056078713,0.01888444,-0.06808971,-1.8330422e-33,0.017372012,-0.03667133,0.047546767,-0.08395622,-0.016243173,0.015715526,-0.0272585,-0.046337128,0.007881774,-0.027412008,0.0913904,-0.014883278,-0.094614,-0.017909283,0.0024544438,0.014374783,-0.04305544,0.048644383,0.00078199955,0.021367814,-0.06136352,0.06332414,0.072347865,0.057440963,-0.008673314,0.052999254,-0.019618465,0.032380793,0.0071753534,0.039967168,-0.033455655,-0.008849096,0.027734047,0.018919725,-0.07933329,0.053509455,-0.07523639,-0.051471982,0.05418546,0.030933676,0.025262674,-0.02715906,-0.033998482,0.07979869,-0.03457807,0.05568563,-0.06514119,0.009315414,-0.06525429,-0.040474504,-0.013764607,-0.012018147,-0.030635469,0.06441327,0.03954402,0.005875915,0.019757023,0.0421947,0.0029440327,0.09979594,0.058208536,-0.056622595,0.018153483,0.0703604,0.03630328,0.007559252,0.029035524,0.04595977,0.051137548,0.06914525,0.07625493,0.09890886,0.09170085,0.016730445,0.083498925,-0.014554552,-0.078460395,0.036029473,-0.058986,-0.06306638,-0.04709638,0.031216748,-0.005527511,-0.054033525,0.028558606,-0.048377823,0.0007628738,0.047926478,-0.0018301642,-0.017329223,0.013605372,-0.045215536,0.02370866,0.11551569,0.0695414,-3.518722e-08,-0.034068674,-0.09862665,0.06288393,-0.049378574,-0.07299144,-0.013207205,-0.0015653529,0.034202565,0.059830114,-0.0083398875,0.039030116,0.06712233,0.009778354,-0.10697382,0.021893071,0.08024129,0.07077414,0.008785282,-0.021600403,0.0795974,-0.056587256,-0.06752422,-0.11373483,0.007670703,-0.038750663,0.009425041,0.017714197,0.033854127,-0.009395941,-0.097284906,0.045358676,0.04183702,-0.025902571,0.0058853184,-0.01736828,0.039512165,-0.015938085,-0.038477626,-0.029570442,-0.022127807,-0.058611296,0.036688283,-0.061050452,-0.01295718,-0.03552129,0.01529171,0.016548796,0.03493129,-0.044095,0.043492384,-0.03814244,0.02748848,-0.0102402475,-0.08636082,-0.10625882,0.014872664,-0.017337887,-0.005998093,-0.049878303,0.024466522,0.037154924,-0.005387179,0.10459834,-0.015813192 +3.4.21.103,"Belongs in peptidase family S53. From the slime mold Physarum polycephalum. Is not inhibited by pepstatin, but is blocked by methyl 2-diazoacetamidohexanoate. Closely similar enzymes are found in Dictyostelium discoideum and P. flavicomum. Formerly included in EC 3.4.23.6.",384,1.0,-0.03949312,-0.07992878,-0.0477094,-0.0014339389,0.05599389,0.032402165,-0.027050823,0.05306333,0.033332493,-0.007313434,0.022167642,-0.057552446,0.01383432,0.008559373,-0.04274674,0.021976557,-0.07685065,-0.039401654,0.014985866,-0.0390926,0.04998245,0.038948778,0.06970788,0.06910675,-0.034739245,0.03158825,0.06362,0.006304074,-0.015328187,-0.121185884,0.00056070223,-0.03549795,0.062983386,-0.0072413096,0.042119555,0.013829016,-0.024987208,0.007888223,0.07436339,-0.031530574,0.06632531,0.0008849499,-0.013894259,-0.0062326994,0.03354496,-0.01485493,-0.04516589,0.06935994,0.031115316,0.022571526,-0.11225616,-0.084111705,-0.0040525883,0.040886592,-0.021148857,0.061379198,-0.014509803,-0.0028570849,0.06154381,-0.031838376,0.050359067,0.01740807,-0.0023570969,-0.0043991664,-0.020998001,-0.0016010504,-0.005584364,-0.05044353,0.041416865,-0.023863854,0.009045869,-0.04215065,-0.0025214406,0.08585747,0.03208617,0.036817502,0.0005530213,-0.047520705,-0.09060998,-0.01911536,-0.03228637,-0.0058931955,0.04036665,0.07847173,-0.0020769027,0.025469804,0.025617328,0.024976555,0.0044399914,-0.066246845,0.03662386,-0.016187232,0.064886406,-0.018480267,-0.06994344,0.02278705,-0.008208361,7.451915e-05,0.038679786,0.017681846,0.020567982,-0.06689154,-0.028580692,-0.031696085,-0.06495667,0.053358383,-0.02755272,0.02699235,0.0977487,-0.008855445,-0.007069475,0.008997544,0.04683471,-0.024026265,-0.01998786,0.018638298,0.047226682,-0.03653532,0.041947287,-0.0025582484,-0.0022919707,-0.022172466,0.06146551,0.011674764,-0.02410346,0.015690079,-0.16703075,5.3594946e-33,0.029710922,-0.07462355,0.044225134,0.038628988,0.028541401,0.019375023,0.018718066,-0.02560195,-0.03193557,-0.117088646,-0.14426318,-0.046291247,-0.016183363,-0.018160759,-0.097241364,0.015767924,-0.048252072,0.0028817651,0.0011608871,0.029376969,-4.837167e-05,0.04571533,-0.054552276,-0.013355775,0.06827214,0.03836451,0.016569752,-0.024601694,0.12881976,0.017873438,-0.09743062,-0.018626567,-0.071024634,-0.01303667,-0.008277141,0.055470694,-0.024023946,-0.051578384,-0.06996665,0.07241013,0.021584464,0.020105185,0.009484038,-0.058218554,0.017291253,-0.021215752,-0.009407763,0.05675786,-0.017132817,-0.0027877246,0.06661227,-0.028047195,0.049768057,0.016817754,-0.040615726,-0.0023298943,-0.03419091,0.046458893,0.08995309,0.026497163,0.10348913,0.0840841,0.0009336167,0.026605673,0.030290177,0.021081302,-0.061804682,0.02789854,0.006399207,0.0602773,-0.017702783,0.0017288814,0.021559328,0.056263603,0.046798583,-0.15580119,-0.048061743,0.0431415,-0.0106531745,0.063166924,0.034501586,-0.074276194,0.0012581336,-0.03802307,-0.055565093,0.008691476,0.026715746,-0.012616333,-0.0724221,0.03192262,0.014570681,-0.12984265,-0.041716266,0.12216079,-0.07011615,-4.853474e-33,-0.011166518,-0.10032364,0.13208722,0.0037953646,-0.02607473,0.007513993,0.010101025,0.057240915,0.011450097,-0.052512124,0.10611213,-0.012233759,0.06676754,-0.052414898,0.04226226,0.06608612,0.022116914,-0.0004128804,-0.020616658,0.005307179,-0.085460685,-0.003498223,-0.05456981,0.07528678,-0.029609188,0.060314838,-0.013378453,0.05808866,-0.005970088,-0.03373249,-0.10815964,0.08191178,-0.079079926,-0.08284364,-0.06884896,-0.026018942,-0.09724696,-0.030453594,0.0031637587,-0.098982,-0.050849807,0.035979483,0.03323054,0.15606058,0.0066380235,0.06783502,0.005890394,0.028926678,0.020322023,0.0036677592,0.013375069,-0.04729886,-0.012104851,0.05757037,0.04390209,-0.0074896277,0.001605852,0.054180868,0.0072326255,0.03095189,-0.009170194,-0.044001576,-0.03752927,0.05052219,0.10874451,0.07690821,-0.10157291,0.072597876,0.05151371,-0.015408583,0.056943696,-0.06030029,0.0440187,0.0646433,-0.023686305,0.057849616,-0.058800757,-0.028590243,-0.0052027334,0.026406763,0.027559383,-0.059670046,-0.012701346,-0.0033147705,0.0106939515,-0.0464419,0.038634103,0.025069177,-0.023504619,0.05321578,-0.00838193,-0.017440435,-0.0027343787,0.024143336,0.043956317,-3.6015855e-08,0.13795684,-0.1159438,0.02860369,-0.032888237,-0.053311497,-0.031230357,-0.0153733445,0.02275888,-0.011116754,-0.04881745,-0.009804746,-0.03349816,-0.0067601735,0.059933163,0.025115896,0.037098847,0.00892577,0.11567654,-0.016345998,0.015740281,-0.08964911,-0.0166666,-0.024381666,0.026715836,0.0013465487,-0.02575084,0.037323955,0.0051071947,-0.003953692,-0.06530918,-0.08120434,0.0015999584,-0.022881038,-0.00020162307,-0.04066879,0.043679602,-0.015762506,-0.025255803,-0.045400992,-0.004985518,0.09103312,-0.06688688,-0.0072098016,-0.049956318,-0.046018433,-0.04996527,0.004134739,0.037006646,0.02364065,-0.024439117,-0.035150044,-0.019102978,0.028600419,-0.034996986,-0.115172565,-0.019328397,0.014973539,-0.05126923,0.0011856747,-0.09822332,0.008369479,-0.058056295,0.21032132,0.07374142 +3.4.21.104,"Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement [7]. This enzyme displays C_overbar_1s_-like esterolytic activity (cf. EC 3.4.21.42, complement subcomponent C_overbar_1s_). It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42 [3]. Belongs in peptidase family S1A.",384,1.0,-0.01374105,-0.04685238,-0.02771888,-0.08895789,0.074829094,0.03589168,-0.02884148,0.06819652,0.007429022,0.04557073,-0.02248211,-0.06423758,-0.033657424,0.008672489,-0.034249328,0.03607399,-0.027042152,-0.020259235,-0.019715525,-0.025174556,0.072719865,0.03981294,-0.009033317,0.04013992,-0.01155221,-0.048811797,-0.015590796,-0.042839047,-0.02521981,-0.0701854,-0.074404076,-0.02658124,0.041925028,-0.025929477,0.039747972,0.004592755,0.06647827,-0.029475426,0.04044296,-0.013836745,7.546753e-05,-0.020635908,-0.03448562,-0.04441012,-0.03487914,-0.03415433,-0.038102843,0.048063617,0.056571066,-0.010645508,-0.01440885,-0.0076077566,0.00569495,0.024040794,0.0347006,0.023106577,-0.09630347,-0.09950764,0.049088977,0.02195833,-0.063317865,-0.013047889,0.058790844,-0.017833922,0.009767047,-0.09731949,0.0006864376,-0.027320413,-0.018644232,0.020508183,-0.050337873,-0.1024529,-0.040298734,0.033068497,0.10003959,0.047408164,-0.034161072,-0.06629458,-0.016500901,-0.0380816,-0.035145,0.03994037,0.048432544,0.08615266,-0.053377204,-0.049588993,0.037685137,-0.042678706,0.021439776,0.036899526,0.056958646,-0.02396822,0.05187894,-0.008301309,-0.023340201,-0.034479234,0.06597692,-0.0029516083,0.06773075,-0.0051574255,-0.0029724897,0.016620826,0.0027798186,-0.048622236,-0.04234124,0.034858298,0.0066485745,0.044228338,0.11766801,-0.06762851,0.0348433,-0.016176956,-0.022033803,-0.01851999,-0.118034594,0.039688148,0.044232756,-0.046814848,0.009734638,-0.027357413,0.006663227,-0.010616312,0.01710329,0.048422057,-0.053021368,0.03823057,-0.07614199,1.8466827e-33,0.07216796,-0.071258314,0.056584958,0.023535598,0.011689281,0.014877469,-0.071991384,0.027705012,-0.05630572,-0.0007124399,-0.118081175,-0.04706623,-0.03514139,0.09173988,-0.060923874,0.060481053,-0.04396134,-0.06516093,-0.003206144,0.017394226,-0.013415973,0.06507316,-0.04580799,-0.06716273,0.11654119,0.030844122,0.006180406,0.0357453,0.029654099,0.00900819,0.029339027,-0.021796387,-0.036472697,0.04312914,-0.012874633,0.020092133,0.06129498,-0.027595498,-0.0057206694,0.013137005,0.021002926,0.037115302,-0.054373994,-0.12841605,0.01700888,-0.044340275,-0.0070385626,0.055820603,-0.043544535,0.07045745,0.03306933,-0.009322521,0.014829585,0.06782549,-0.0626396,0.040651605,-0.06494165,0.015931617,0.10041158,0.039512124,0.022223575,0.07709571,0.013539855,0.014024339,0.026154459,0.07296326,-0.08020421,-0.032897208,0.03959933,0.019714946,-0.08584162,0.023747081,0.035148464,0.04862657,0.05055468,-0.082272485,-0.05441112,0.0738973,0.0038148644,0.110293396,0.09744286,0.02075186,0.031675536,0.0037616193,-0.12426294,-0.04930468,-0.039421875,-0.13192233,-0.053331986,0.033005025,-0.01330789,-0.058550086,-0.04023939,0.10466554,-0.08701506,-4.2465843e-33,0.10545613,-0.15536377,0.117714286,0.027033769,-0.07888213,0.0032766915,0.056427237,-0.051760696,0.015961807,-0.005503558,0.13950002,0.011271106,0.020504098,-0.022941042,0.03924798,0.047189422,-0.03278,0.03853412,-0.07681191,0.06665185,-0.08005049,0.059808593,0.05199675,-0.026602665,0.059881367,-0.02878977,0.018078098,0.074998595,-0.017398361,-0.0363435,-0.04294259,0.013326817,-0.034584623,-0.08839708,-0.04552067,-0.047104567,-0.049849033,0.03743569,-0.016728854,-0.027820623,-0.035065405,0.037445717,0.041699525,0.025443543,0.04820263,0.0497592,-0.032134593,0.009939103,0.043187268,-0.015652696,0.02058442,-0.052553453,0.05116286,0.009413065,0.1101737,-0.004023867,0.049586855,0.04311573,0.023520065,0.016565083,-0.02073552,-0.02600729,0.04705634,0.01218132,0.069822416,0.054636985,-0.08065703,-0.05106522,0.1304591,-0.05699546,0.12224403,-0.033327296,0.1041748,0.016114596,-0.0014501889,0.055302024,-0.07248748,-0.098196715,-0.038444787,-0.007166644,-0.084705286,-0.05446613,-0.0057797953,-0.04567725,0.020620603,0.054867994,0.032404657,0.07093205,-0.06383799,0.045775674,-0.05511889,-0.013926403,-0.0691626,0.018519199,0.035692878,-4.2602526e-08,0.11149609,-0.059783813,0.043741666,-0.07638336,-0.036744922,0.02662131,0.036973692,-0.018337704,0.0304978,-0.014060084,0.0054481057,0.05406565,-0.00882865,-0.04150584,-0.0020842801,-0.014658008,-0.028850209,0.03383515,-0.015199792,0.015696608,-0.12214989,-0.009115495,-0.02446901,0.00048781917,0.033034116,-0.114011906,0.01729924,0.09402197,0.02833771,-0.053080376,-0.011830489,0.04003284,-0.00294256,-0.03619888,0.035749756,0.01281633,-0.076377146,-0.014306839,0.0236201,-0.0046817358,0.06450576,-0.030231118,0.01693499,-0.067743115,0.0063331993,0.00022755003,-0.0025465994,0.101748474,-0.05099333,-0.010687767,0.051138118,0.009803689,-0.033672974,-0.008358339,-0.010574838,0.010473116,-0.0069027226,-0.06325528,0.008733727,-0.024804037,0.014243175,-0.051247735,0.042166494,0.0038874068 +3.4.21.105,"These endopeptidases are multi-spanning membrane proteins. Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains. A catalytic dyad is involved in proteolysis rather than a catalytic triad, as was thought previously [14]. They are important for embryo development in Drosophila melanogaster. Rhomboid is a key regulator of EGF receptor signalling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway. Belongs in peptidase family S54. Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Rhomboids are widely conserved from bacteria to archaea to humans [9,13].",384,0.99999994,-0.04257666,-0.031780846,-0.081740625,-0.076461285,0.122525126,0.10366116,-0.0011517999,0.07403625,0.023787783,0.050351713,-0.051126577,-0.012172021,-0.06713795,0.067070924,0.007854146,0.10058674,-0.113993265,-0.009823812,-0.06290607,-0.08676688,0.052722935,0.008239128,0.026424821,-0.057301223,-0.042499363,0.006438335,0.040502224,-0.063901655,-0.04644184,-0.053028334,0.061169785,-0.07561349,-0.0032233428,-0.054262165,-0.016624996,0.07799105,-0.00687236,-0.021756077,-0.033451777,-0.05255764,0.079517595,0.06988918,0.007967182,-0.039349128,-0.060023844,-0.0400301,-0.07450223,0.114730366,0.054607086,-0.025760317,0.035054255,-0.117225,-0.04059745,0.042195637,0.053515773,0.06898225,-0.051291995,-0.040782936,0.051690277,-0.058022846,0.03871844,-0.036926456,0.0721578,-0.038220216,0.022127772,-0.105466984,-0.013826342,-0.019123372,-0.00023531784,0.043210473,-0.049654756,-0.0099615585,-0.08090457,0.038734544,0.05968708,0.043270487,-0.035206344,0.012109861,-0.016961902,-0.03387764,-0.025508968,0.044231907,0.10945021,0.057614706,0.043122582,-0.022076253,-0.016753932,0.008850302,0.018470041,0.03660784,0.08717516,-0.08047526,0.010794852,0.07893123,-0.10069991,-0.018444527,0.002349172,-0.07624821,-0.022150733,-0.041907966,-0.038094826,-0.023710433,-0.024529656,-0.057198916,-0.05275746,0.0015428829,-0.022236038,0.089150466,-0.022411125,-0.07038044,0.00970563,-0.033104345,0.09169519,0.07771963,-0.026160197,-0.014748342,-0.078710735,-0.028955983,-0.005190326,0.044608317,-0.0022935567,0.048365626,-0.023743337,0.015474425,-0.054493308,0.009017294,-0.13947017,3.6898852e-33,-0.0036423544,0.0053118696,-0.021220278,0.046766613,-0.04013414,0.021803876,-0.024566988,0.0641702,-0.041637484,-0.021423671,-0.09976236,-0.051977262,0.02167092,0.034407947,-0.0365496,0.029961491,-0.030784378,0.07055708,0.0035885507,0.02111685,-0.027179303,0.027526142,-0.0053656767,-0.097489715,0.10006663,0.022560777,-0.0040491824,-0.0074575576,0.05809668,0.009782576,0.027309883,-0.08379244,-0.053523555,0.07092856,0.0280731,0.054026525,0.022258071,-0.039325085,-0.05961658,-0.014471193,0.0013547834,-0.017243542,-0.17614166,0.029900948,0.04691907,-0.07621328,-0.025054662,0.038766295,-0.004280462,0.0072218827,0.07477018,-0.008942049,0.09356897,-0.03083965,-0.07511707,0.0044470993,-0.06389227,0.020689806,0.044681124,-0.00442771,0.012214752,0.051703546,-0.024079321,-0.008717807,0.020251881,0.009844323,0.015338523,-0.09830075,-0.055757765,0.047755033,0.006202194,-0.030203296,0.08325998,0.048182935,-0.016707728,-0.04202936,-0.009338368,0.04604812,0.055624854,0.049166795,0.03448502,0.014812071,0.013625775,-0.011007952,-0.022601092,-0.08047604,-0.0024183749,-0.09052766,-0.043543734,0.05673006,0.04236945,-0.049635477,-0.05568413,0.060630016,-0.008202968,-4.4019696e-33,0.020828657,-0.05945474,-0.016608464,-0.078887396,-0.023660816,0.08524258,0.02425105,-0.04781878,0.042559057,-0.09079982,0.02951625,0.018805455,0.013382804,-0.033100363,0.057066526,-0.053870287,0.016110048,-0.004502293,-0.030773679,-0.0902074,-0.057795715,0.034404766,0.0037373696,0.060822375,-0.05191348,0.04046952,-0.030286452,0.08060751,0.0018462947,0.03925329,0.06860441,0.04557994,-0.03852904,-0.009602215,-0.035458237,0.048236318,-0.06923972,-0.022754984,0.07360072,0.023370031,0.013564693,0.026785282,0.0091971215,0.01250221,0.041373484,0.07337749,-0.06965482,0.0868548,0.061275534,-0.091125034,-0.030193424,-0.018411499,0.024089944,0.0016414381,0.024822725,0.05273912,0.029053977,-0.0070911334,0.11393334,-0.0250568,-0.01957792,-0.04367467,0.04562261,0.059838727,-0.00061384006,0.026253117,0.039572846,0.0034058224,-0.0027001095,0.026815588,0.065980144,0.016902294,-0.024882022,0.019832252,-0.09470435,-0.015158241,-0.0015275045,-0.07711842,0.03172619,-0.00877972,-0.033491943,0.026576424,0.061025314,-0.0034520095,0.07827554,-0.052558582,0.020526528,0.075078905,0.01936797,0.056291528,-0.019087657,-0.07633486,-0.040856853,0.07339214,0.071464315,-4.167727e-08,0.10705309,-0.043664612,0.021881908,-0.07668228,-0.046006385,-0.016996581,0.0028360481,0.0010629761,0.024869978,0.016123246,0.0029417218,-0.047178183,0.038802132,0.028307123,0.070437066,0.06972959,0.035597753,0.010019773,-0.017640974,-0.050312273,-0.07713221,0.02256994,-0.07425664,-0.020600224,0.06396603,-0.08253242,0.079714395,0.050859205,0.005228289,-0.02958718,-0.020967323,0.03696687,0.024420206,0.07024269,0.0020688516,0.07568217,-0.008404218,-0.0039281994,0.0031894445,-0.02081827,0.037523124,0.027185082,0.026657727,-0.043554176,-0.023817163,-0.0076650176,0.07701827,0.017958805,-0.06111241,0.018089104,-0.023179583,-0.02526528,-0.006371388,-0.07550795,-0.12838352,0.004308978,-0.08951952,-0.053812336,0.025327425,-0.05409709,-0.0021175968,0.028260348,0.12015682,-0.030422596 +3.4.22.1,An intracellular (lysosomal) enzyme in peptidase family C1 (papain family),384,1.0,-0.076404706,-0.055875655,-0.11750246,-0.086653166,0.06896706,0.017717807,-0.09800596,0.054533787,0.07416024,0.03420169,0.03422143,-0.039772894,-0.010368576,0.025443893,-0.01979258,-0.0546374,-0.1455145,-0.026140489,-0.03881787,-0.11005755,0.009480722,0.04735342,-0.038398344,0.03969857,-0.036694396,-0.041316956,0.031029942,-0.0071432367,0.013747137,-0.05905737,-0.03681184,-0.031787887,0.08129056,-0.021538222,0.049608875,0.046195216,0.00070558896,-0.051457852,0.092886284,-0.04690597,0.09412302,0.037619323,-0.0062191417,-0.09821291,0.020690845,-0.016700506,-0.01826421,0.07529186,0.092980675,-0.04080687,-0.047389794,-0.09156693,-0.016179124,0.02238139,-0.034871157,0.020387074,-0.007673864,-0.036723424,0.09748499,0.042116396,-0.046556056,0.0143060405,0.016547149,0.001219993,-0.04661946,-0.097420864,0.028531233,-0.019661788,-0.03354197,0.0026216137,-0.0014926057,-0.030034117,-0.006148714,0.048490155,-0.005818669,0.046819113,-0.028657937,-0.04020331,-0.09741397,0.02275346,0.038430244,0.020081827,0.07310173,0.07227746,-0.0047963043,-0.036593433,0.035426952,0.020608623,0.024543924,-0.067990385,0.05090565,-0.08345724,-0.010018481,0.033045657,-0.1088019,-0.01537423,0.035833407,-0.03278682,0.008932571,-0.009873004,0.041849226,-0.0037838619,0.019700421,-0.047153424,-0.035080723,0.12086171,0.00071982667,0.10227247,0.07183818,-0.011285749,0.0016654716,0.010952228,-0.008882179,-0.060487483,-0.048046086,-0.0051883617,0.026579991,-0.020730214,0.026209088,0.060265385,0.03505474,0.037171308,0.049712416,0.06326065,-0.039170988,-0.008345189,-0.06863251,-8.484879e-34,-0.010385345,0.009810187,0.041661162,-0.0024592653,-0.031944018,0.001964161,-0.05129213,0.0148780355,-0.02432498,-0.09661485,-0.04638873,-0.03997544,-0.03058625,-0.06039679,-0.05524702,0.037982244,-0.040812634,-0.054962974,-0.01984689,0.05228026,-0.03533488,0.0062192297,-0.049346898,-0.03150787,0.11994266,0.05171354,0.0391897,-0.045723278,0.049579617,0.0012148579,-0.045959495,-0.011748023,-0.073980145,0.058226306,0.016860079,0.063399255,0.039372865,-0.041223105,-0.019745199,0.017881827,-0.030730784,-0.028142486,-0.0010442311,-0.084510095,0.017140813,-0.06284773,-0.032142963,0.033758916,-0.011405671,0.0423797,0.0010620591,-0.059959803,0.106325924,-0.0076293135,-0.06752376,0.010873365,0.007462303,-0.023781428,0.09729862,0.05989252,0.104035415,-0.021775857,-0.06847104,0.0817795,-0.033347957,0.0039223423,-0.09904203,0.014936725,0.016527347,0.079070374,-0.054039042,-0.0028400656,0.08973552,-0.017937407,0.057635244,-0.049748566,-0.029234488,0.04172473,-0.014922431,0.07101607,0.07893246,-0.0059101144,-0.00047965327,-0.0077852616,-0.042167895,-0.024848372,0.011301199,0.027386567,-0.111920916,0.03502387,0.023061289,-0.03778537,0.0016933605,0.07076218,-0.06335163,-1.9893695e-33,0.124553286,-0.046250172,0.11358221,-0.094987236,-0.09172299,0.04899457,0.033537075,0.03297458,0.042176437,-0.015993323,-0.020514647,-0.037922774,-0.013647858,-0.06598578,0.021711519,0.03949168,-0.01227811,0.07136463,-0.022659158,0.033906195,-0.097773656,0.021622814,0.008041976,0.03881613,0.018789817,-0.0152038,-0.04640702,0.10673445,-0.0141363405,0.0074628005,-0.06551673,-0.011786811,-0.0433825,-0.045113496,-0.036481727,0.028428705,-0.02253151,-0.055461764,0.06289394,-0.036743175,-0.018703418,0.076118715,0.05060496,0.040263772,0.009214017,0.06511998,-0.02768085,0.026819477,-0.059371408,-0.02344181,-0.03170476,-0.031140456,0.02014339,0.06565972,0.017645795,-0.007640526,0.035141815,0.094040066,0.0012369078,-0.000798888,0.033080127,-0.04751043,-0.068615004,0.11375605,0.035488587,0.0101352185,-0.079268195,0.0022347595,0.08266758,0.058344856,0.004611004,0.009368021,0.051924083,0.033160422,-0.0056654247,0.064997785,-0.098744206,-0.116733305,-0.026641166,-0.051329117,-0.00927211,-0.047492463,-0.021975495,-0.03389208,-0.006026739,-0.07148061,0.04315587,0.062305987,0.018731557,0.02194562,0.041749947,-0.0041387817,0.05994873,0.029254138,0.07003009,-2.3744219e-08,0.07475906,-0.07067117,0.0123167485,-0.06349525,-0.060107473,-0.025400022,-0.008279739,-0.052503794,0.035764944,0.025594145,-0.03966126,0.00015185539,0.0023995738,-0.002984185,-0.06412689,0.11498061,-0.03799598,0.04127589,0.042764112,0.0773458,-0.057991564,0.016302858,-0.07353225,0.056749403,0.0027659992,-0.008787113,0.0007361618,0.04671262,-0.02408566,-0.017692357,0.0099324,0.012403318,-0.02261272,-0.063540794,-0.033962715,0.047941282,0.0009266909,-0.031228855,0.010761199,-0.039167285,0.10134595,-0.039052658,-0.07064625,-0.09871684,-0.009023805,-0.0023842496,-0.011696176,0.042587258,0.005849222,-0.014380839,0.05252016,0.005428522,-0.052685417,-0.06043004,-0.038511768,-0.034263134,0.029139332,-0.032015473,0.05205252,-0.0772591,0.02174293,0.08172106,0.17489523,0.0010711494 +3.4.22.2,Type example of peptidase family C1 from latex of the papaya (Carica papaya) fruit. Inhibited by compound E-64 and proteins of the cystatin family.,384,1.0,-0.055854272,-0.0023829725,-0.06088827,-0.058189914,0.059054043,0.10932056,-0.053407073,0.06666813,0.0461921,-0.008294415,0.06433022,-0.03539792,0.033525113,0.0035129169,-0.02241221,-0.01398978,-0.077595785,-0.010535553,-0.0059886295,-0.1000098,-0.0149217695,0.048109673,0.001919839,0.07372216,-0.059528455,-0.0061314977,0.026440632,0.012933331,0.04536917,-0.0682094,-0.028410148,-0.030624274,0.082892224,-0.026486399,0.03297218,0.012258439,-0.014020589,-0.07698733,0.03458421,-0.0046447413,0.101102255,0.04476806,0.00387728,-0.0817588,0.08163327,-0.08456515,-0.069102466,0.08068334,0.05366842,-0.09463985,-0.038325284,-0.052609965,-0.036536,0.024150174,0.041199706,-0.034097474,-0.019669697,-0.015060827,0.07881497,0.02580656,0.0005534506,0.011632005,0.0012148089,-0.039083384,-0.04809497,-0.06094743,-0.027100222,-0.010171363,0.018072328,0.043019254,-0.065973625,-0.036015466,-0.01909387,0.06889741,-0.04606336,0.08677495,-0.028384848,-0.09992019,-0.14898664,0.01947957,-0.001413276,-0.009819758,0.070227474,0.07067428,-0.0040765405,0.017456457,9.3137234e-05,0.021567972,0.038805228,-0.01015815,0.07879935,-0.05919414,0.050624754,0.01841552,-0.07512492,-0.035498887,0.04469091,-0.092100516,0.03539232,0.021745231,0.059544545,-0.020759866,-0.023765849,-0.0529787,-0.0721175,0.06647072,-3.656611e-06,0.03328814,0.04747874,0.023971649,-0.03941815,-0.055837285,-0.1103698,-0.11585042,-0.13114062,-0.021193687,0.017229162,-0.012321148,0.010574358,-0.009206617,0.074596904,0.0081992345,0.05139771,0.009992804,-0.018320912,-0.025406338,-0.10841387,1.0182358e-33,-0.0276942,-0.027202208,0.07063124,0.048405446,0.051211406,-0.014600912,-0.056792226,-0.011052043,0.020453569,-0.11212856,-0.06972575,0.02025788,-0.04431566,-0.03157748,-0.04648725,0.05830661,-0.046298627,-0.060987853,0.0062137498,-0.005863691,0.022234462,0.040603515,-0.039349247,-0.025924042,0.046973795,0.028381422,0.008461636,-0.031131877,0.05512629,-0.008652445,-0.06904404,0.009846445,-0.101468965,0.02205744,0.04584348,-0.0024222296,0.04888508,-0.08139278,-0.015557656,0.023363892,-0.023349807,-0.022835664,0.02806413,-0.06292381,0.03008825,-0.06868358,0.0062136515,0.03198583,-0.033293873,0.05749741,0.01033571,-0.040972985,0.039640486,0.010178622,-0.085607484,0.014077212,-0.017276991,0.007809025,0.048276674,0.07792255,0.079409786,-0.012694914,-0.001963878,0.0072224047,-0.048028246,0.013522197,-0.09691598,-0.005358087,-0.0062457654,0.108597584,-0.045897905,-0.015100241,0.09204052,0.0030598515,0.05563005,-0.09540686,-0.076026,0.085187495,-0.02275952,0.08093887,0.02423103,-0.04003826,0.02051827,0.022641651,-0.049304824,0.012302831,-0.02786243,0.06573239,0.005766976,0.04661993,0.004027189,-0.05177498,0.019056069,0.102107,-0.05457192,-3.6107322e-33,0.04796868,-0.019408373,0.08385324,-0.05234597,0.024033329,0.027690733,0.03682641,-0.038368247,0.0023992646,-0.08919755,0.057678,-0.015547367,0.03160073,-0.030260874,-0.013416232,0.04611808,-0.0034325146,0.08849304,-0.10747674,0.031702634,-0.10735638,-0.08196899,0.01611008,0.054202218,0.03924397,0.009064377,0.0025242905,0.0137677295,0.0031025668,0.0007353432,-0.05221014,0.003505196,-0.049238257,-0.03375292,-0.04954672,0.021322042,-0.028326204,-0.017520605,0.043407843,-0.0049039233,0.013211093,0.04437108,0.03526787,0.040978864,0.000856236,0.05826243,-0.011611702,0.01896077,0.047508307,0.011093554,0.010940121,0.0018998287,-0.023608126,0.045290288,0.03348647,-0.01493049,0.04040119,0.051389467,0.0043017166,0.06702902,0.037118405,-0.02347348,-0.07027372,0.03765949,0.090528615,-0.0162173,-0.041419774,0.011629449,0.09523425,0.009686879,0.07003169,0.005266597,0.03960863,0.014432806,-0.051463626,0.020961387,-0.038372714,-0.0711004,-0.005471345,-0.041342624,0.0429906,-0.045268968,-0.020122007,0.032335874,-0.016843665,0.000104537416,-0.007878999,0.029404866,-0.02052593,0.040542126,0.042559776,0.03215847,0.04758607,0.13574642,0.010051029,-2.7953346e-08,0.07355661,-0.14163473,-0.0005047509,-0.0821078,-0.06081895,-0.012834122,-0.07499112,-0.0461085,0.026096243,-0.050301354,-0.01727941,0.036821365,0.0026790877,0.047946412,-0.056467682,0.04342056,0.0075786915,0.06630966,0.035877403,0.05673895,-0.13519034,0.003091295,-0.03363873,-0.009531388,-0.036033235,-0.05326753,0.027289392,0.10133213,0.010835628,-0.022320895,-0.003948047,-0.009232652,-0.06489346,-0.049481157,0.0300665,0.073108755,0.010667706,-0.016299443,-0.054524038,-0.010232526,0.08747128,-0.05165269,-0.09201339,-0.06400576,0.014578514,0.013674045,-0.02502156,0.04950197,-0.044481557,0.041897733,0.025571968,0.033047963,-0.0090134675,-0.056887377,-0.049068447,-0.018477438,0.05658614,-0.07308795,0.08233238,-0.07641941,0.0596358,-0.0045696963,0.17212716,0.083008036 +3.4.22.3,"The major proteolytic component of the latex of fig, Ficus glabrata. Cysteine endopeptidases with similar properties are present in other members of the large genus Ficus. In peptidase family C1 (papain family).",384,1.0,0.014313714,-0.06664681,-0.039395403,-0.03844637,0.123430446,0.07464021,-0.0025881135,0.13980052,0.06118078,0.08288049,0.09639235,-0.054980073,-0.057428595,0.05702452,-0.053586517,-0.053931702,-0.06589005,-0.041354045,0.008703447,-0.029661814,0.06647913,0.036721885,0.0038393463,0.016031573,-0.006079599,-0.031158889,-0.061688043,-0.023777584,-0.041039526,-0.052739747,-0.07999355,-0.06656813,0.05418174,0.021162694,0.0859568,0.06410573,-0.034581777,-0.04247537,0.05263302,-0.044231206,0.016085494,0.029553369,0.0015463204,-0.016232489,0.018671764,0.06155419,0.0324471,0.0953682,0.053684458,0.05377425,-0.056131948,-0.09496326,-0.019050956,-0.008905064,0.020765824,0.022139432,0.056293666,-0.09434246,0.032580085,0.0721687,-0.05943531,-0.021568054,-0.05057709,-0.05832791,0.020962026,-0.06679562,5.196412e-05,-0.013894384,-0.054951154,0.042417243,-0.0077928384,-0.018698314,-0.059351444,0.043354757,-0.008310547,0.0757178,-0.11998446,-0.0983562,-0.110817835,-0.005344997,0.08413676,0.032201268,0.10207723,0.06157238,0.022773484,-0.009888967,0.05593278,0.045254637,-0.03609776,-0.0077408655,0.021409443,-0.017333832,-0.04702025,0.08182189,-0.0378361,0.0127245365,0.008564837,-0.0017714973,0.032815665,-0.04098649,0.011573957,-0.077787444,0.08394157,-0.15343899,-0.058270752,-0.0003442983,-0.0019761738,0.047214627,0.072712176,-0.044455282,-0.03560433,-0.024767872,-0.106241725,-0.06003515,-0.021684071,0.063448645,0.024564197,-0.048891783,-0.053979386,0.049761843,0.053114332,0.0703347,0.06548329,0.09397992,-0.028253874,-0.0038672653,-0.07652861,1.34960325e-33,0.0072777746,-0.001532749,0.002667096,0.025164274,0.014280534,-0.02485108,-0.058331642,-0.0229345,-0.004770971,-0.010993338,-0.093406014,-0.0034165552,-0.07083719,-0.024136443,-0.025197783,-0.0002245049,-0.010568256,-0.03278306,0.009172248,0.0026286007,0.031890225,0.06415727,-0.027798276,-0.008477339,0.058731012,0.1056794,-0.016957866,0.0053154286,0.05952453,-0.0049751005,0.026102012,-0.071686916,-0.05000972,-0.013272814,0.052279778,-0.041607864,0.0274001,-0.072863795,-0.020178866,0.026465315,0.0032537843,0.018133996,-0.008925228,-0.017357022,0.04648606,-0.08975688,-0.043823253,0.08090036,0.0029594891,0.019675642,0.06359406,-0.034144152,0.05436596,0.017274272,-0.041580282,-0.005668167,-0.053228445,0.02611101,-0.0069795633,0.043528333,0.13680804,0.005415933,-0.081198774,-0.051839203,-0.04896668,0.051330734,-0.07556289,0.017402386,0.0030808768,0.09621332,-0.082279444,-0.014879719,0.0713258,0.024532964,0.04687107,-0.051693205,-0.07285091,0.075731,-0.043345325,0.025550129,0.013937669,0.030592298,-0.029681494,-0.016949108,-0.067186214,0.018851364,0.03958683,0.03230703,-0.08517494,0.04514389,0.035247803,-0.0024659422,-0.011471381,0.08237855,-0.10858837,-2.2879903e-33,-0.013375418,-0.03659814,0.01678128,0.00861564,-0.05395508,0.05631413,-0.023951696,-0.013750489,0.025538687,-0.049320992,0.01008224,-0.06580571,0.025249708,-0.021589732,-0.021481225,0.0032043415,-0.04515418,0.060159598,-0.04629221,-0.03602406,-0.056975275,-0.0036544064,0.100451484,-0.024009295,0.068525836,0.044303928,-0.01306671,0.04450013,-0.019000458,0.06226777,-0.010506447,-0.03527757,2.7669921e-05,-0.04132847,-0.06697669,0.042892497,-0.060734395,-0.04806959,0.07351543,0.063827336,-0.015767958,0.0087105185,0.06832353,0.046060883,0.0025477856,0.036476266,-0.050722156,0.032607887,0.011552316,-0.037877757,-0.017563028,-0.015636193,0.008752113,-0.04804582,-0.013772775,0.00042063423,0.015691675,0.06731172,0.026691908,0.012166497,0.00826747,-0.07173249,-0.0024975094,0.03459375,0.10594678,0.0054733306,-0.06562646,-0.004541453,0.08074474,0.09150201,0.05566642,-0.0062103462,-0.04438008,0.027671313,-0.005102868,0.07499043,-0.047735613,0.0061001964,-0.019069111,-0.024072729,-0.021820987,0.010035302,-0.01957664,-0.02793162,0.018271191,-0.04395551,0.0072037536,0.05944654,-0.017830294,0.030606983,-0.040856265,0.016842876,0.08175449,0.08317826,0.020354787,-2.8780603e-08,0.05268508,-0.019555487,0.00024671457,-0.09290417,-0.004229415,-0.015904507,-0.0030318138,0.009448053,-0.0030000051,-0.027331721,0.005691822,0.03950934,0.0014938469,-0.005668372,0.00074164296,0.028264796,0.020107027,0.051010657,0.026769979,0.05225732,-0.08821189,0.02548236,-0.11261922,-0.014141368,-0.10890454,-0.03355135,0.045816883,0.059162036,-0.0845365,0.041954085,0.054380253,0.026408317,-0.049705334,-0.057232887,-0.08794417,0.104373366,-0.09053471,0.0029367614,-0.053110402,0.040519267,0.0468945,-0.0529994,-0.054494344,-0.038653698,-0.01428452,-0.024305284,0.10331522,-0.019995162,0.005811001,0.050848737,0.020445453,-0.007730219,-0.05334408,-0.0043417895,-0.069549344,-0.03692857,0.06346519,-0.038702082,0.032100566,-0.0696451,-0.03842252,0.003007219,0.17255084,0.056454558 +3.4.22.6,The major endopeptidase of papaya (Carica papaya) latex. It has multiple chromatographic forms. In peptidase family C1 (papain family).,384,1.0,0.012918872,0.0009321017,-0.07332997,-0.039207246,0.037483614,0.07438575,-0.08143655,0.08324101,0.03248579,-0.009628714,0.05695373,-0.042564973,-0.11363801,-0.010562135,-0.0035669815,-0.026223162,-0.057795066,0.018874416,-0.0046335026,-0.08858211,0.034548145,0.025855538,0.009207672,0.015754336,-0.046930194,0.021193288,-0.020720804,-0.047885757,0.06502705,-0.09901434,-0.016587688,0.0029268048,0.09165703,-0.063737735,0.041304816,0.04393833,-0.037527356,-0.08162113,0.06478997,-0.025167493,0.12118656,0.04469397,-0.010164617,-0.040830854,0.058202777,-0.049328804,-0.06538648,0.08346253,0.04727626,-0.049337108,-0.048613373,-0.106082484,-0.049842007,-0.009365793,-0.0074079153,0.011282835,0.050994042,-0.06541343,0.039858516,0.09504546,0.0020616448,0.0020785534,-0.037377458,-0.061202426,0.002392605,-0.07877305,0.008828746,-0.08029993,0.0045257723,0.012546049,-0.045172416,-0.018131878,-0.045319278,0.057601206,-0.06615844,0.048456684,-0.07651935,-0.090451114,-0.08590276,0.046933226,0.05641434,0.023168214,0.043582663,0.06644918,0.010274482,0.024799991,-0.040130526,0.06059164,-0.0057314537,-0.0040416676,0.011127535,-0.08101048,-0.008758383,0.0077770557,-0.010815153,0.009318969,0.06823716,-0.12172418,0.06499934,-0.035949506,0.028672632,-0.06937059,0.0032854017,-0.10725201,-0.06347486,0.036155418,-0.027440762,0.039432846,0.111955196,-0.015520557,-0.045596622,-0.0063342433,-0.08397323,-0.15395658,-0.08294375,-0.03523044,0.023098625,-0.021318093,0.023880428,0.03953741,0.033918153,0.048513748,0.055977862,0.019528667,0.026163207,-0.037749212,-0.044339973,1.37236385e-33,0.0037300084,0.045638546,0.080360614,0.012333419,0.037840273,0.024353644,-0.044785596,-0.008099095,0.005954666,-0.035605453,-0.07445339,-0.020510897,-0.08406812,-0.004457901,0.0017874605,0.053653844,-0.07027315,0.0013269681,0.010390636,-0.0141157275,0.014485993,0.047953464,-0.033645578,-0.00989588,0.059172403,0.06867855,0.009876651,-0.03738252,0.024749354,-0.0030567178,0.038340766,-0.04063903,-0.07227664,0.03136394,0.021318125,0.050653126,0.047174647,-0.118086964,-0.03194015,0.013383641,-0.005380753,-0.0070535336,0.012232419,-0.012755683,-0.01972605,-0.10394449,0.032751072,0.014053645,0.028666867,0.04345961,-0.033568487,-0.025589744,0.062168065,-0.017688382,-0.0583441,0.03935963,0.024232885,0.04031498,0.026405893,0.083653204,0.07668557,-0.00070416514,-0.052492112,-0.031500284,-0.052697465,0.005203906,-0.06430796,0.025194053,0.04655396,0.059084024,-0.020212455,-0.024888925,0.09167957,0.010985005,0.074314564,-0.005823649,-0.09597664,0.0698436,0.04173205,0.041753758,0.0478877,0.03558391,0.051462054,-0.032084495,-0.028231349,0.042495195,-0.035450198,0.01684309,-0.039948646,0.07759848,-0.051802974,-0.013852797,0.024949457,0.08790162,-0.061108995,-2.3232336e-33,-0.02354399,-0.06556062,-0.0077843587,-0.00815439,0.0013367797,0.0067743585,-0.026703993,0.023844851,-0.022819422,-0.025577316,0.091583356,-0.06337083,0.05148061,-0.044890508,-0.020246241,0.069676936,0.0073236325,0.11025256,-0.022834545,-0.026794633,-0.072587654,-0.046112623,0.021160813,0.029442888,0.12182268,0.016162997,0.01925358,-0.017191568,-0.00835482,0.02628941,0.02055309,-0.07826177,-0.009875012,0.0071264864,-0.06208628,0.037384354,-0.08766002,-0.008229817,0.08842412,0.07498438,0.0052740863,0.0010379305,0.104255505,0.02807988,0.011056614,0.0058184443,-0.06549923,0.024389885,0.08965279,-0.018581603,-0.031255633,-0.011353699,-0.045279216,0.02593681,0.00085708895,0.009396095,0.01030539,0.04762898,-0.034911573,-0.026126519,0.022667008,-0.021937326,-0.003734075,0.033412207,0.12117085,0.01362459,-0.040998336,-0.012336019,0.030478686,-0.006316673,0.03864269,0.023568902,0.03793132,0.058727194,-0.05308206,0.01676465,-0.003287979,-0.04047902,0.037640437,-0.04897555,0.047547825,-0.07346773,-0.042662907,-0.004287463,0.024619337,-0.02737427,0.00017469308,0.040256646,-0.028239662,0.064216,-0.06402401,0.0766926,0.024890166,0.057013046,0.023728762,-2.91192e-08,0.086706124,-0.096068725,-0.012563019,-0.10703407,-0.0052556004,-0.034076508,-0.040227655,-0.045786444,0.036136378,-0.035541512,-0.008858333,0.006694495,-0.013491714,0.02199858,-0.021266216,0.018782236,0.04932534,0.03824006,0.06397081,-0.0124855265,-0.12386256,0.02350776,-0.038555853,-0.081033304,-0.01376672,-0.001194169,0.029821591,0.09403591,0.03574594,0.04611421,0.024034271,0.004782111,-0.08486708,-0.041136142,-0.024512121,0.113698736,-0.0037856188,-0.012500624,-0.04420073,0.020298604,0.10269627,-0.049357206,-0.0821108,-0.01799456,0.0032638914,0.0038783737,0.049180176,0.028388053,-0.04596321,-0.009211989,0.026826806,-0.07562856,0.0034479313,-0.021440888,-0.05390513,-0.0025119528,0.0684772,-0.056082517,0.054675493,-0.0452097,0.022218728,0.086919874,0.20045006,0.08427738 +3.4.22.7,"From the latex of milkweed, Asclepias syriaca. It has multiple forms, and is in peptidase family C1 (papain family)",384,1.0,-0.05252747,0.048415687,-0.09222235,-0.020253122,-0.044149056,0.02205187,-0.068048425,0.054638766,0.05272621,-0.06106163,0.10415728,-0.09665999,-0.01937755,-0.053082716,-0.08233134,0.03919755,-0.048752896,0.019336164,-0.011539041,-0.0888191,0.043793097,0.108709306,0.069686964,0.079782784,0.024764527,0.041574433,-0.039557353,-0.021484232,0.092302345,-0.13622512,-0.018559348,0.070980765,0.12983797,-0.023485115,0.031069394,0.0416585,0.002783998,-0.057421837,0.14395694,0.015814075,0.05006598,0.0036585801,0.028405245,-0.049760368,-0.055591762,0.02160516,-0.04299531,0.08961075,0.11258525,-0.027148128,-0.066283025,-0.09898846,-0.01870976,0.03592046,0.032280937,0.017394988,-0.037699748,-0.0071959766,-0.022356449,0.04889714,0.011493626,0.030040799,-0.034810755,0.03377895,-0.0895543,0.031846788,0.010749725,-0.06633638,0.037970543,-0.07180944,-0.03303735,-0.061670884,0.032554124,0.052140392,-0.093288556,0.026918605,-0.0016748271,-0.048262835,-0.039076246,-0.010646874,-0.0130682085,0.06876133,0.04264473,0.0166126,-0.013278469,-0.007125394,0.016338086,0.0479431,0.025915567,-0.0724986,-0.019179052,-0.04963662,-0.015368008,-0.023041233,-0.09079489,0.04454651,0.088706106,-0.03961974,0.04396687,0.022995554,0.060706045,-0.060115818,0.013193483,-0.034783024,-0.06333511,-0.00540627,-0.089238495,-0.035452228,0.08418981,-0.030943241,-0.0793699,-0.076454766,-0.069434255,-0.06261144,-0.08753578,0.029461239,0.023019664,-0.04147236,0.032591127,0.009969949,-0.03285673,-0.010777304,0.034956265,0.016754441,0.006883457,-0.017283402,-0.12052844,-4.6004335e-34,0.018825367,0.033450898,0.058957156,-0.007671619,0.033472963,-0.06382301,-0.012579231,-0.034813844,-0.023615936,-0.1394337,-0.02773882,-0.07263605,-0.09069543,0.023918426,-0.026491135,-0.00791476,-0.06602084,-0.033885334,-0.026176937,-0.02164587,-0.048099793,0.08934943,-0.051476266,0.0014977802,0.015854998,0.021404395,0.081891246,-0.026982969,0.03738737,0.013830793,0.048546754,-0.056320295,-0.08831071,-0.016047597,-0.028298536,0.06620424,-0.027958345,-0.11856073,-0.03069242,0.11864152,-0.009855756,0.01747183,0.09535494,-0.0054363282,0.0012495611,-0.004482753,-0.031104079,-0.021431671,0.04765046,0.027786097,0.008805869,0.00905881,0.01902673,-0.009281866,-0.029415399,-0.004762416,-0.0012852316,0.08057574,-0.013545774,0.0776209,0.10007967,-0.009559134,-0.038343698,0.034947596,-0.015279724,0.010183884,-0.0943318,0.03699926,0.022557605,0.030884434,-0.04713104,-0.018639747,0.035226446,0.036404714,0.054663774,0.046781905,0.01840344,-0.0019586263,-0.032157578,0.015495782,-0.02236352,0.020558964,0.02846457,0.0041316273,-0.08949134,-0.009118989,0.014555455,0.035255387,-0.059718113,-0.002808883,-0.02859194,0.00053719507,-0.028391154,0.00033741037,0.008216943,-2.0630791e-33,0.027023528,-0.032708656,0.07423183,-0.056693602,-0.023305578,0.010456377,0.03650499,0.10735262,0.060866404,-0.033997595,0.009208198,0.001310766,0.059428573,-0.045699812,0.044865422,0.05004408,0.043594413,0.10803537,-0.005167304,0.0040401965,-0.0677458,0.069659,-0.042371728,0.05364362,0.021982482,-0.017715186,0.03607124,-0.01325164,-0.020387989,-0.0049352227,-0.016902398,-0.09636157,-0.069404915,-0.005884873,-0.047398556,-0.0010930641,-0.042122964,-0.056408077,-0.034441717,-0.033906072,-0.004510093,0.03938789,0.11344073,0.04064244,-0.0139796315,0.0107050715,-0.021656357,0.037922144,0.012494689,-0.02219703,0.015797365,-0.00951994,0.0474344,0.037631508,0.028687645,-0.02382942,-0.0070354873,0.044857804,-0.021423943,0.0021003678,0.010851619,0.03239029,-0.05435739,0.012328586,0.041287962,-0.0078050666,-0.12728837,-0.07590414,-0.007763652,0.039863687,0.04307087,-0.005426263,-0.046109404,0.03329339,0.0008839806,0.06685624,-0.053043902,-0.04746127,-0.019370573,-0.039164286,0.0123579735,-0.064435884,-0.055025637,0.059160884,0.03831966,-0.04682489,0.03570758,0.034094844,0.06585876,0.05816363,-0.021995014,0.03712169,-0.0442391,0.09445203,0.083988905,-2.6755327e-08,0.08809179,-0.05147702,-0.0009171741,-0.06991293,0.033030916,-0.00018157737,0.00044460242,-0.06437825,-0.010128971,-0.031845633,-0.05587316,0.061574925,-0.020307424,-0.012239526,-0.0247854,0.0018474715,0.015402124,0.08279775,0.039297245,0.009615596,-0.058236543,-0.0507026,-0.012149242,-0.035384454,-0.05629072,0.056097843,0.066470236,0.07458683,0.033649832,-0.04451188,0.06952196,0.065904304,-0.01164932,-0.08333541,-0.009495936,0.044078633,-0.031011414,-0.033252385,-0.0047757737,0.025782527,0.11377038,-0.06229207,0.025373422,-0.037793964,0.004882905,0.034796122,-0.005671921,0.026358893,-0.00842945,-0.0041842405,0.0318615,-0.037080128,-0.0070200944,0.012496959,-0.08880468,-0.06638682,0.041912556,-0.06915321,0.06076328,-0.04185852,0.03183748,0.017444931,0.19275828,0.09366482 +3.4.22.8,From the bacterium Clostridium histolyticum. It requires Ca2+ ions and is inhibited by EDTA. Type example of peptidase family C11.,384,0.99999994,-0.037056033,-0.016332842,-0.07567274,-0.009570783,0.03400956,0.017018447,-0.0018714224,0.075082496,0.047314495,0.059268627,0.0445916,-0.07663234,0.032113355,0.09907548,-0.05292934,-0.081409834,-0.028184315,-0.029092073,-0.00947434,-0.018819598,0.089832544,0.10926974,0.005263713,0.02013439,-0.070974745,0.0069518317,0.024739537,-0.012639418,0.04262326,-0.096634015,-0.006087043,-0.07691026,0.10931663,-0.04259584,0.0885234,0.027566802,-0.029199613,0.019164965,0.07219342,0.004001046,0.052526932,0.04662758,0.076717906,-0.021607723,0.023568269,-0.042975854,-0.017302563,0.05367404,0.04285519,-0.032964226,-0.02274364,-0.030180002,-0.011193937,0.065133154,0.04997773,0.0057606935,-0.03860347,0.0013745587,0.0384078,-0.04971667,0.035916183,-0.015380328,0.019902887,-0.0050437367,-0.030210484,-0.0583469,0.040953077,-0.066536725,0.02147272,-0.005508134,-0.031893022,-0.05559811,-0.039353985,0.064278655,0.027154433,0.01241565,0.024384411,-0.09884839,-0.04180434,-0.04666222,-0.054140083,0.0027545379,0.025611361,0.08589634,0.013191435,0.08079024,0.08455307,-0.011367118,0.06536686,-0.034760024,0.066666946,-0.011139392,0.08609944,-0.0672466,-0.060261413,0.018460188,0.030575555,-0.055259574,0.017062206,-0.004009663,0.04975539,0.026704093,-0.07792438,-0.033854496,-0.09080028,0.02376078,0.0018444149,0.03849121,-0.015953204,0.026594568,0.011949537,0.0022099272,-0.015779024,-0.025358614,0.009244209,-0.009490326,0.07819853,-0.042010333,0.025391556,-0.021799209,0.013142973,-0.08175225,-0.026729586,0.021143537,-0.06517128,0.05458615,-0.058457535,2.8552043e-33,0.0052962927,-0.0313846,0.03724611,-0.008191278,0.011369791,-0.00928101,-0.05323001,-0.039320994,0.018914443,-0.10242534,-0.04211414,-0.03054661,-0.014652046,0.039150916,-0.10276671,0.03342201,-0.0852465,-0.041055467,0.055906706,-0.008627841,0.018760987,0.07981126,0.02878323,-0.028462935,0.09674813,0.02667383,0.02971619,-0.0047490397,0.045932207,-0.009648898,0.01851964,-0.034522347,-0.08193759,0.028932538,0.02706656,0.03110247,0.021146405,-0.016542053,-0.0013009766,0.07068488,0.030425234,0.033536922,0.01348901,-0.025613932,0.073853455,-0.06849097,-0.06468358,0.08587046,-0.00647089,0.049857024,0.023079213,-0.016295535,0.055192742,-0.053769503,-0.09360274,0.0293347,0.00597954,-0.0031511267,0.07551979,0.07688709,0.041009504,0.07664835,-0.038791712,0.068946876,0.024400953,-0.010467153,-0.08823011,-0.058312412,-0.012797881,0.017420536,-0.0944724,-0.036447972,0.011788119,-0.018790487,0.022547726,-0.092313096,-0.11607704,0.05343944,-0.002229957,0.03626647,-0.047089294,-0.053976092,0.01806367,0.023420298,-0.054775517,-0.018799573,-0.07955084,0.009948999,-0.05308386,0.0022067188,0.02817575,-0.04966204,0.0004876406,0.04015826,-0.010166233,-4.375337e-33,0.07662566,-0.04799882,0.06369914,-0.025020007,-0.009674448,0.042327084,-0.044253893,-0.024263894,0.08005239,-0.051380076,0.036878847,0.008836981,0.022855524,-0.058472756,0.034227163,0.036430445,0.048845015,0.08356061,-0.06467366,-0.0056483555,-0.049014986,0.021077596,-0.0073962305,-0.008209465,0.038228296,0.041912746,-0.053620644,0.045781873,0.03668268,-0.02362938,-0.061623085,0.03924117,-0.027664293,-0.07146068,-0.13085242,0.00049825426,-0.062059443,-0.029827008,-0.034291234,-0.00647212,0.021848924,0.059437938,0.07689209,0.09736428,0.006538657,0.05256615,-0.027442802,0.06405145,0.008069921,0.024365395,0.0076314257,-0.05918005,-0.012764134,3.947344e-05,0.09337822,-0.00793455,0.039194148,0.04432561,-0.019626642,0.018883683,-0.015596606,0.0062090494,-0.05538866,0.019732665,0.055952564,0.02316445,-0.122023515,0.017720744,0.052203108,-0.04619667,0.06822064,-0.009189415,0.03456998,-0.088547274,-0.08155609,0.077773646,-0.07627667,-0.03584311,0.056095283,-0.037423037,-0.017160922,-0.0026919523,-0.012742374,0.0074518146,0.02924192,-0.06451166,-0.030313801,-0.015482512,0.049636453,0.0620783,-0.028814225,-0.061401032,0.050703894,0.06000026,0.0536372,-2.9259676e-08,0.067393795,-0.058652654,0.060941037,-0.051789,-0.031834044,-0.0056546815,0.019037785,0.038073253,0.064248994,-0.03624194,-0.009830859,0.057176676,0.06585421,0.037553314,0.026323006,0.10941199,-0.043220002,0.022849424,-0.025873909,-0.028220357,-0.13071373,-0.085186005,-0.052356087,0.05113479,-0.023889821,-0.017290622,0.050138004,0.012890903,-0.033685207,-0.048473347,-0.01227227,-0.001778164,-0.033871867,-0.10308318,0.026122045,0.05056226,0.0032395977,-0.06474824,0.002592776,-0.05164348,0.05740906,0.003957125,-0.103988215,-0.035556972,0.038438432,0.019014245,-0.07299214,0.04351654,-0.08791734,-0.026878783,-0.009749806,-0.019624727,-0.02649517,-0.08950296,-0.16340943,0.006248638,0.044309746,-0.089575306,0.036077473,-0.07717916,0.08075089,0.066096775,0.1793903,0.073843874 +3.4.22.10,"From the bacterium, group A Streptococcus. Formed from the proenzyme by limited proteolysis. Type example of peptidase family C10.",384,1.0,-0.047440883,-0.100413024,-0.14175016,-0.010487712,0.04864605,0.063250996,0.00039488554,0.085454606,0.03448567,0.010562692,0.056833133,-0.054285936,-0.0034184752,0.036459614,-0.08619844,-0.05864049,-0.086483605,-0.06785167,0.034772772,-0.04188303,0.0650015,0.06230147,-0.016970932,0.032232124,-0.015821999,-0.015674304,-0.010354323,-0.029416604,0.06320548,-0.021661103,0.0026243709,-0.02815045,0.12586252,-0.057718176,0.15009983,0.06137222,-0.038309526,-0.0031533015,0.07281318,0.030741243,0.030378459,0.050156128,-0.004053864,-0.048447426,0.008384889,0.039188642,0.10102789,0.15704975,0.041831125,-0.08173282,0.0034383228,-0.032720286,-0.119339876,0.053780004,0.025570938,0.013621682,-0.03166792,-0.052165657,0.034761522,-0.055613592,0.022387538,0.015186834,0.0242812,-0.030689834,-0.028932812,-0.005647746,0.04012401,-0.013456662,0.023603449,0.015152643,-0.032774836,-0.0021376128,0.010808436,0.10750034,-0.018259907,0.052814934,-0.004683244,-0.0653037,-0.08397308,-0.05067331,-0.006643514,0.022315916,0.03823385,0.027930394,0.00023192755,-0.025857555,0.06676166,-0.008403034,0.06458585,-0.03173809,-0.03788498,-0.05410533,0.060040433,-0.044233866,-0.066549286,-0.038176626,0.00026274318,-0.053765733,0.106673464,0.01985085,-0.009062591,-0.026878078,0.08167279,-0.0057241996,-0.016227616,0.027649896,-0.06521572,0.041799333,0.07541849,0.049230896,-0.028562978,0.029164555,-0.06582202,-0.0761092,5.227825e-05,-0.06984802,0.028411968,-0.058437504,0.00020523746,-0.0051455605,0.047335546,0.017816605,0.0537442,0.015825072,-0.042441085,0.073879294,-0.07321205,8.310999e-34,-0.02859625,-0.03091504,0.07942524,-0.0009754182,0.022359155,0.010530106,-0.10226748,0.009268903,0.05726853,-0.084427245,-0.037358727,-0.075048424,0.0030148027,0.014568063,-0.057266515,0.040074367,-0.07132625,0.01238902,0.030428832,-0.019279001,-0.08518745,0.13567008,0.0031691438,-0.011836786,0.055312205,-0.038056374,-0.0030988157,-0.01990807,0.050399233,-0.016667692,0.022266177,-0.016294979,-0.09539951,-0.0014266488,0.051828034,0.019880006,0.0058465432,-0.08932945,0.060190946,0.029664375,-0.011628326,-0.006645469,0.005480008,-0.031098126,0.098776154,-0.08616676,-0.04044125,0.030331897,-0.048322327,0.07410654,-0.032441504,-0.014432306,0.06529804,-0.0126333395,-0.088881195,-0.01406247,0.02559856,0.063922994,0.080146745,0.075015694,0.052137647,0.098269776,-0.052256837,0.036488667,-0.015814077,-0.014551783,-0.047516525,0.02304692,0.025111472,0.052912734,-0.052634142,0.008050918,0.008418077,0.012257434,0.02496104,-0.0585377,-0.053220488,0.04976389,-0.021721024,-0.003782381,-0.0380553,0.03019069,-0.024239037,-0.036994383,-0.11626595,0.059362203,-0.042353857,-0.029859316,-0.07092874,0.014260661,-0.07493866,-0.043796677,-0.015835095,0.07496233,-0.04699435,-2.929307e-33,0.0556258,-0.07744223,0.031072736,-0.04371868,-0.0024093369,0.046709657,0.011429327,-0.013345482,-0.030862238,-0.029056223,0.015138647,-0.046494193,0.017958693,-0.030395603,0.0016170053,-0.056083143,0.007095127,0.07222523,-0.039875988,0.053100992,-0.002811488,0.006889041,0.0018552231,-0.029510621,0.02642095,0.012297226,-0.04741278,0.09545051,0.041689377,-0.004066229,-0.024415938,0.014338035,-0.0041330983,-0.074979,-0.10790751,0.026220527,-0.050654992,0.02381549,0.028499234,-0.05134072,0.06521543,0.08137324,0.067357406,0.045448165,0.00021219438,0.037999205,0.00073379674,0.024414662,0.044311963,0.01033607,-0.007863318,-0.036068894,-0.023895245,0.029222386,0.0009899014,-0.033501834,0.0125587145,0.024455195,-0.051955827,-0.009207702,-0.0051830783,-0.046321277,0.009533115,0.05095976,0.12433559,-0.08189251,-0.09125911,-0.0029018936,0.10172321,0.009690382,0.050279845,0.0008292089,-0.0121073155,-0.04149229,-0.016708871,0.051480114,-0.09008318,-0.06750223,0.0070336433,-0.05716892,0.01179177,-0.08996088,0.033561684,0.067807004,-0.019480921,-0.072909914,0.033201218,0.00687356,0.06759677,0.087784074,0.023859555,-0.03976148,0.05646018,0.075262986,0.020294173,-2.7473565e-08,0.06074236,-0.004047634,0.076261446,-0.006677983,0.034828477,-0.07149738,-0.033119112,-0.06073917,0.0570413,-0.022814149,-0.019316077,-0.0253811,0.014339647,-0.029977903,0.010701977,0.06648505,-0.12571608,0.015920201,0.0067712963,0.024896272,-0.11927416,-0.049021956,-0.05865226,0.053838413,-0.01699534,-0.050032493,0.04459101,0.015705448,-0.07038928,-0.03599652,0.009559282,0.047973286,-0.06966601,-0.05455169,0.03468407,0.028750742,-0.03771677,0.023946134,-0.012541947,-0.010535046,0.042848997,0.015841462,-0.062605724,-0.028109932,0.015315816,0.023759436,-0.04055278,0.028801952,-0.07338103,-0.017003624,0.04627206,0.03138822,-0.05652655,-0.010151773,-0.11235177,0.01288119,-0.004801645,-0.039272822,-0.0040711137,-0.026141122,0.051213056,0.041853774,0.15938973,0.064324565 +3.4.22.14,From the kiwi fruit or Chinese gooseberry (Actinidia chinensis). In peptidase family C1 (papain family),384,0.99999994,-0.119875886,0.018713187,-0.11989641,0.016414046,0.036848776,0.09126992,-0.001811017,-0.034421597,0.0676534,-0.016038021,0.15829013,-0.081719585,-0.021078287,-0.049667113,-0.049130186,-0.012116663,-0.056514822,-0.016331427,-0.04122878,-0.07728246,0.041076828,0.044165425,0.0049231932,0.0336972,-0.06491855,-0.031884044,-0.042197976,-0.00947047,0.073135644,-0.09822813,-0.017297613,0.043632615,0.09978213,0.039849035,0.03334649,-0.009159114,0.06679425,-0.074975714,0.10925119,-0.014649406,0.043607596,0.025633084,0.09400293,-0.050737716,0.04360463,0.056061704,-0.04518859,-0.0077459337,0.100426905,0.011476377,-0.08588211,-0.07162124,0.04361546,0.008215155,0.084519796,0.0065903123,-0.05006976,-0.00804953,0.02605134,0.09735705,-0.0041355533,-0.0030406257,-0.049066275,-0.033831768,-0.112039715,-0.06259479,-0.050300635,-0.01199626,0.07981473,-0.050263613,0.050532907,0.0067840274,-0.01995025,0.059577424,-0.10666509,0.03733141,0.031098256,0.0025436985,-0.13233303,0.053385712,-0.033829764,0.03717079,0.044246916,0.05565625,0.002604477,0.034157503,-0.024375426,0.032421086,-0.024668057,0.025734454,-0.017176503,0.007646816,0.008110268,0.06551572,-0.09447999,0.004726957,-0.014403962,-0.047238335,0.014317649,0.044787,0.028638503,-0.010364279,0.0063642175,-0.052650593,-0.059509918,0.016883519,-0.10829236,0.0031401867,0.0745063,0.032020677,-0.020945743,-0.017808398,-0.102036275,-0.021174235,-0.06173831,-0.06294509,0.010559602,0.0022036848,-0.02107958,-0.025765708,0.015079127,0.06131197,-0.005113638,-0.019275794,-0.061028883,0.010938114,-0.08459463,1.594912e-33,0.004315532,0.033497706,0.04712768,-0.034642592,0.014508698,-0.079148024,-0.034205247,-0.0182973,0.03296462,-0.10067188,-0.102338396,-0.013133515,-0.08924403,-0.035020757,0.012690612,-0.004623269,-0.08220208,-0.049104393,0.065802775,0.046214614,-0.016381398,0.028230298,-0.029560711,-0.10897757,-0.065067366,-0.03214665,0.04987793,-0.07564822,0.04442981,0.006641251,0.06590716,-0.03108301,-0.01575738,-0.039945383,-0.051156145,0.0042124144,0.013347699,-0.09123095,0.027272714,0.13834439,0.06680404,-0.03653265,0.055141415,0.06761719,-0.04126276,-0.035896372,-0.037821062,0.028104024,0.08783676,0.040616713,-0.01597303,-0.044765897,0.09650096,0.0054709814,-0.049132522,-0.047395807,0.017197544,-0.008380749,0.008646621,0.04125559,0.0065457146,-0.04593266,-0.001718248,0.025500948,-0.022778673,0.0016452802,-0.09798624,-0.01589859,-0.044163216,-0.012397003,-0.003245591,-0.042560875,0.099085025,-0.10437344,0.040691253,-0.043138772,-0.012838179,0.02453726,-0.00096715335,0.04043191,-0.029634677,0.061951395,-0.016038684,0.05558181,-0.12720557,0.041186098,-0.014550933,0.04361156,0.041875925,0.020667627,-0.09711086,-0.047603976,-0.012144862,0.02105334,-0.054365654,-2.2404164e-33,0.037890308,-0.017327227,0.034156747,-0.013135884,-0.0034406066,0.025501883,0.01289895,0.0040256754,0.009344138,-0.00631717,-0.03463657,0.006634089,0.08002783,-0.014584248,0.00981985,0.088561304,0.043787505,0.14182772,-0.0009275237,-0.03930668,-0.085267894,0.032223437,-0.042696,0.034904346,0.031865153,0.050240926,0.09123457,-0.021573711,-0.028317748,-0.03446479,-0.030480085,-0.13288,-0.08029495,0.010833462,-0.035243127,0.04595972,-0.06623012,-0.018871153,0.039825935,0.017375086,0.02684482,0.090052955,0.039718192,0.07698588,0.02617397,0.04290609,-0.022797398,0.0024482242,-0.00487996,0.027054215,0.06103553,0.04020854,0.03615087,0.018500362,-0.006460584,-0.058386892,-0.022882804,0.05283458,-0.036905367,-0.04199273,-0.007850319,-0.021367803,-0.059839096,0.064000964,0.0558015,0.09683524,-0.032778736,0.017975861,-0.010418578,-0.0027327694,-0.008185422,0.026375417,0.07004237,0.010908108,-0.027252244,0.047138844,-0.058101147,-0.082234964,-0.02611896,0.01877412,-0.029806033,-0.04485445,-0.038663886,0.023697434,-0.02093033,-0.026201556,0.021469552,0.024755714,0.09365946,0.027202398,-0.028211422,0.057275433,-0.013798489,0.02284231,0.039946444,-2.4111257e-08,0.09884647,-0.049316633,-0.03265565,0.029331574,-0.02321204,-0.027001204,-0.021605114,0.0151212495,0.053566977,-0.011659929,-0.056149352,0.01895336,-0.0075508137,-0.0012323003,-0.012938046,0.02206181,0.030133165,0.07864074,0.073582515,0.072126314,-0.08434939,0.036002327,0.042402055,-0.037089538,-0.08089985,0.008030531,0.038908944,0.038788565,0.014103101,-0.023029523,0.028887007,0.03702383,-0.03656559,-0.04459137,0.03482796,0.040713713,-0.007459364,-0.012096297,-0.02145842,-0.043939244,-0.0153915,-0.034855887,-0.056896985,-0.010136834,-0.03729323,-0.0024631598,-0.033074025,0.06780564,-0.0015794588,0.051784135,-0.00064740574,0.021104421,0.025675906,-0.002947747,-0.104203485,-0.0063754995,0.05592364,-0.100969344,0.05346844,0.024231981,0.005207985,0.04137199,0.123257376,0.097323 +3.4.22.15,A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64,384,1.0,-0.07200979,-0.01266528,-0.12424918,-0.024191493,0.0821338,0.04609257,-0.10421495,0.07105781,0.04801554,0.039535884,0.01850066,-0.009407259,0.013333739,0.044654213,-0.048267297,0.011800284,-0.12593676,0.014058823,-0.029066637,-0.08489289,-0.008940161,0.056784026,0.039580595,0.095232405,-0.04851378,-0.045235563,0.0064602485,0.008918381,0.035778757,-0.06440339,-0.015347944,-0.01690969,0.09786766,-0.01111442,-0.0011016304,0.014271206,0.03560028,-0.014902143,0.05630358,-0.01796771,0.060441423,0.0358334,-0.04541389,-0.08556999,0.02337762,-0.05089811,-0.015645754,0.0947762,0.02283845,-0.03436745,-0.033213124,-0.09277861,-0.057872534,0.0490521,0.0014142988,0.03151913,-0.026846943,-0.04324999,0.060227223,0.038923446,0.01022118,0.0006054323,0.012535874,0.026048817,-0.045563515,-0.053268835,0.008531466,-0.041199617,-0.01930712,-0.013545706,-0.006924382,-0.09626183,-0.0022278128,0.062554345,0.022039488,0.046663035,0.0023378707,-0.036105648,-0.10452726,-0.0095375,0.021729924,-0.0560016,0.0665115,0.10358916,0.038120832,0.008427664,0.010641913,0.034672722,0.07794134,-0.05289421,0.050708286,-0.07050361,0.0059056627,0.03418995,-0.10244767,-0.011379284,0.010511196,-0.05221186,-0.03148386,0.032295547,0.059599996,0.0014792139,-0.02677564,-0.056558196,-0.018304367,0.06568915,0.029766291,0.06421671,0.010792794,-0.025192047,0.0051601264,-0.037678853,-0.012610449,-0.0382735,-0.066156544,-0.006298566,0.08814608,-0.013655853,0.010496422,0.056291163,0.08538391,0.051927466,0.01911448,0.025496388,-0.032634582,-0.015247367,-0.08727416,2.5542286e-33,-0.017604703,0.038757823,0.014306366,-0.0068013296,0.016199052,0.027568046,-0.08047848,-0.019341685,-0.004630543,-0.11896792,-0.06585314,-0.01052459,0.010568531,-0.03657077,-0.008282727,-0.0020589277,-0.05321745,-0.035625167,-0.00789447,0.0016254568,-0.0018512851,-0.03190495,-0.09184571,0.023411237,0.0986541,0.07030452,-0.0074795503,-0.033246167,0.040953074,-0.0063010235,-0.058756057,-0.026881658,-0.0889049,0.02353185,-0.012246673,0.017666815,-0.006968896,-0.058019556,0.020217994,0.013608807,-0.07270734,-0.007862118,-0.020410426,-0.049149558,0.015638493,-0.10120557,-0.03244845,0.07798049,0.006004648,0.024778746,0.022386726,-0.07278896,0.059945285,0.0060442556,-0.07481568,0.021815727,0.03125118,0.0074919746,0.07558813,0.045920413,0.09665184,-0.0040092575,-0.04853223,0.07875723,-0.016420752,-0.0102457525,-0.093588285,-0.04530756,-0.036781717,0.06267614,-0.091829516,-0.012879869,0.13318446,0.0027889232,0.043682404,-0.12303169,-0.020791257,0.050581846,-0.0013905831,0.06226451,0.040819313,-0.05864066,-0.013942724,-0.0139937615,-0.028653352,-0.030687798,-0.02710082,0.026404254,-0.083816655,0.02058437,0.027917761,-0.050848305,0.034818653,0.07605452,-0.028456049,-4.1427183e-33,0.09637931,-0.060772944,0.15084916,-0.05317648,-0.0131321,0.019368194,-0.0029765652,-0.019444482,0.048273943,-0.10127989,0.037758335,-0.057972357,0.048243567,-0.0322401,0.056196153,0.049906008,-0.0026196262,0.03600127,0.006730702,0.02287684,-0.06863288,0.008818252,-0.0033034827,0.046359826,-0.010540888,-0.027474219,-0.03172822,0.048639487,0.00061654736,0.029659322,-0.108938836,-0.06312081,-0.04686763,-0.08167014,-0.040656768,0.061729163,-0.004316989,-0.02680934,0.008371204,-0.045944847,0.011685687,0.029173547,0.038977433,0.036009904,0.0215341,0.10650398,-0.038328346,0.020521114,-0.050627332,-0.015558544,0.010596976,0.040464345,-0.02096602,0.07493536,0.033617493,-0.029338414,0.016797975,0.0064179148,-0.01960924,0.03734326,0.011811257,-0.034941968,-0.075558364,0.12672813,0.030535879,0.018616037,-0.08716076,0.082206346,0.08425501,0.045065448,0.04367542,-0.026006348,0.03351227,0.028609008,-0.054798212,0.046787687,-0.091259845,-0.117678046,-0.016035266,-0.06567548,0.011138626,-0.044376787,-0.006861582,0.016718304,-0.014949474,-0.06786263,-0.0068362462,0.07216582,0.03270186,0.032571163,0.012779055,-0.012119844,0.07580814,0.0300923,0.06269178,-3.3356446e-08,0.10017304,-0.11501429,0.024501162,-0.07965004,-0.04224567,-0.0668418,-0.017399613,-0.020947834,0.030254647,0.0021119358,-0.011602653,0.063986436,0.013422772,-0.017912364,-0.020410987,0.1012655,0.013058655,0.102618754,0.028575102,0.04112606,-0.06342082,0.018385608,-0.03634044,0.015948106,0.013510527,-0.011013595,0.017503442,0.04532005,-0.047813836,-0.030163446,-0.002508219,0.018813515,0.013124221,-0.010271341,-0.020234924,0.053385485,-0.01427242,-0.04306469,-0.038522974,-0.003871731,0.08943246,-0.03127088,-0.07319629,-0.047220565,0.008878059,0.016638895,0.03346606,-0.013089453,0.025551086,-0.037982035,0.03996822,0.031333726,-0.008497195,-0.07959444,-0.086046465,0.015352391,0.03194952,-0.041411076,0.059919525,-0.093674704,0.048781455,0.04514071,0.20520939,-0.0070229555 +3.4.22.16,Present in lysosomes of mammalian cells. In peptidase family C1 (papain family),384,0.99999994,-0.056731272,-0.08409877,-0.10459703,-0.08980072,0.07432997,0.059791174,-0.05321621,0.04112889,0.10032673,0.05570396,0.049173206,-0.0077763903,-0.005034047,0.016817683,-0.008640188,0.006321908,-0.11225766,-0.02198382,-0.047943447,-0.064977,-0.014598519,0.030931327,0.005019442,0.05022142,-0.047963392,-0.058225997,0.025965523,-0.008126081,0.017494196,-0.057530608,-0.052131314,-0.04021011,0.014209976,-0.0023747678,0.03227157,0.029690769,-0.029053451,-0.012455284,0.10127474,-0.058609508,0.09142802,0.0028342484,0.0049552466,-0.08575917,0.035188418,0.008739544,-0.006011951,0.05913119,0.10056705,0.024161186,-0.01241964,-0.059465308,-0.030916223,-0.016003834,-0.06752355,-0.004959473,-0.06484312,-0.007019767,0.14474602,0.045895696,-0.050523173,0.0018483689,0.027829202,0.0029486958,-0.020810878,-0.13780943,0.014496222,0.021776795,-0.022163266,0.03419514,0.040584505,-0.01791349,0.018105306,0.09534377,0.02106542,0.110522605,-0.00670799,-0.01485248,-0.084795475,-0.00855288,0.032253005,-0.013296774,0.11158675,0.09176713,-0.015229372,-0.03318421,0.005335632,0.07426298,0.012152529,-0.08674759,0.06066681,-0.09342868,0.03667311,0.090085216,-0.07265133,-0.015897335,0.059008047,-0.022391647,-0.011060078,-0.018339021,0.015945315,-0.002505693,0.009298161,-0.018185057,0.014726682,0.08508295,0.00297833,0.07075002,0.042176478,-0.025645487,0.017321095,0.012501594,-0.025188306,-0.051206235,-0.036515728,-0.05340948,0.015391418,-0.026249213,0.03912138,-0.006043208,0.021582678,0.08412764,0.044226706,0.0553932,-0.06180074,-0.020010214,-0.06346639,-1.3356011e-33,-0.008510562,0.0068641254,0.040463474,0.04290518,-0.04511551,-0.013851774,-0.0096003665,-0.03256411,0.0021080987,-0.091500245,-0.056303445,-0.021573972,-0.0074144397,-0.0066265217,-0.08044762,0.035245422,-0.034085996,-0.09696893,-0.006149468,0.029862428,-0.07056003,0.012657214,-0.046065014,-0.030018315,0.11437461,0.025088962,0.0052867783,-0.028433405,0.009497103,-0.004037321,-0.062105607,-0.0054991627,-0.0618873,0.08374927,0.01730098,0.0654134,0.031540014,-0.04936749,-0.009211319,-0.024180083,-0.042698864,-0.042143352,-0.025562374,-0.09852262,0.028055936,-0.019001437,-0.03328931,-0.019608332,-0.08995232,-0.0033505345,0.022008099,-0.047981158,0.051250327,-0.005032774,-0.06969623,-0.04403039,0.020685352,0.0055594705,0.08497519,0.060545254,0.081599586,-0.026561037,-0.03104419,0.09896237,-0.02074384,0.017798658,-0.10567403,-0.01630588,-0.037002493,0.05777792,-0.0030864167,0.00035566912,0.13171816,-0.05170417,0.04139986,-0.008671806,-0.0047095674,0.05032405,-0.05097837,0.09075206,0.084153004,-0.039090022,-0.038437977,-0.019031808,-0.048429105,-0.006923337,0.05378904,0.016871195,-0.065708265,0.011191934,0.011090931,-0.040164046,0.006246634,0.05949113,-0.07951415,-1.7914606e-33,0.065827206,-0.00801242,0.11412225,-0.06422239,-0.06143792,0.0340929,0.049089387,0.001128798,0.028700963,-0.033605702,-0.012154052,-0.050303612,-0.047193296,-0.043032188,0.041431315,0.02939925,0.0025550365,0.019109229,-0.012654687,0.02842415,-0.1477066,0.03148086,-0.0389728,0.047843724,0.047991306,-0.015817206,-0.06838278,0.057515725,0.0018420079,-0.050931767,-0.07579045,-0.037823766,-0.015319517,-0.028731676,0.022237003,-0.005425806,0.015392119,-0.062031742,0.05387865,-0.070239976,-0.011609925,0.054562815,0.01036236,0.06602883,0.03474441,0.08275079,-0.009707627,-0.0037632876,-0.04187654,-0.012694821,-0.020358628,-0.061949857,0.023490721,0.017421542,0.03386568,-0.014489848,0.041979194,0.07064151,0.016547956,-0.00076515117,-0.0028519325,-0.04998506,-0.07630929,0.086615995,0.04321237,0.034833074,-0.102228545,0.01454165,0.038729575,0.07568054,0.030397233,0.012700484,0.055232782,0.03187069,0.012773531,0.07707233,-0.057182148,-0.096384205,0.00050952856,-0.024437845,-0.008431354,-0.0571115,3.0659205e-05,0.0067343013,0.036752753,-0.044785205,0.01720956,0.07344864,0.009269627,0.024842322,0.08189592,-0.0775827,0.06858783,0.041896068,0.03452951,-2.3967912e-08,0.10813957,-0.07077705,-0.0013210307,-0.11163866,-0.04885569,-0.050830144,-0.016402936,-0.028819075,0.016823985,0.034982137,-0.05144552,0.017295389,0.00010450586,0.0013285724,-0.054855507,0.09635507,-0.035638086,0.035039417,0.06656547,0.04118422,-0.045926217,0.026989356,-0.0622912,0.06202745,0.018917369,-0.0010990299,0.004943852,0.0048943223,-0.0127616525,-0.048630062,0.004827985,0.0075125904,-0.015431744,-0.0825175,-0.026268592,0.026601486,0.037834123,-0.07726729,0.03003878,0.016151698,0.098916166,0.010576069,-0.07197188,-0.09259783,0.00015252904,-0.016081356,0.0026451012,-0.010656999,-0.025088698,-0.057914414,-0.016838036,0.027843488,-0.047322948,-0.06963642,-0.0552543,-0.021810692,-0.017580885,-0.0060234256,0.08056192,-0.09657541,0.0056228777,0.0922743,0.16659513,-0.01154562 +3.4.22.24,Degrades azocasein and denatured hemoglobin; the only native protein on which it has been shown to act is tyrosine aminotransferase,384,1.0,-0.013338942,-0.021259207,-0.059145775,-0.018670764,0.008125323,-0.0017634503,0.10442615,0.09405453,0.083320804,0.04830691,0.0063164965,0.043181248,-0.054019045,0.12553626,-0.067485444,0.01067003,-0.03952865,0.027810166,-0.023104778,-0.049928878,-0.013624069,0.09952798,-0.01078556,0.024029832,0.03707625,-0.06640738,0.036847796,-0.038372897,-0.021707041,-0.03742164,-0.06287641,-0.06314892,0.0721027,-0.042110782,0.033058852,0.07653874,-0.007809969,-0.13030502,-0.024864975,-0.092740245,0.12213722,0.06209975,-0.06813763,-0.025136488,-0.052251637,-0.004328165,0.04279502,0.026036644,-0.011253509,0.13842735,-0.034550335,-0.038990162,-0.023636224,0.026067544,0.022923993,-0.01946397,-0.120605424,0.017211627,-0.041392766,0.04355794,-0.028152464,0.0674328,0.030635279,-0.055956636,0.058002867,-0.010739654,0.06907719,-0.0027343591,0.02277695,-0.03472927,0.006839372,-0.0036895995,-0.034875624,-0.028109603,-0.07407459,0.039413042,-0.017562298,-0.0412082,0.015853122,-0.07699911,0.0027547884,0.033621054,0.093441844,0.070639804,0.040224202,0.04466756,-0.06772819,0.0022107945,-0.06042325,0.033866145,0.021768034,0.035726216,0.10952486,-0.021710567,-0.0030584172,-0.045381278,0.009012115,0.062172126,0.003570924,0.04666395,0.014774257,0.07787626,0.015889687,-0.04140094,-0.044195898,0.059202764,0.012807933,0.019874664,-0.005400031,0.007803152,0.011285627,-0.0032056086,0.11233448,0.0005788428,-0.0014264385,0.100369036,-0.015735302,0.016934244,-0.06988576,0.027743492,-0.0580777,-0.034778327,0.07027428,0.0128813945,0.038842533,0.069911554,-0.057982117,3.491742e-33,0.042798497,0.0011537969,0.050530493,0.06279007,-0.059311256,-0.019634059,-0.027570248,0.022893628,0.013976844,-0.038646296,-0.08349389,-0.11045695,0.059344977,0.04230861,-0.018429888,-0.02350804,-0.046659634,-0.032796714,0.027790956,0.14498326,-0.029174346,0.04008863,-0.018303731,-0.07302813,-0.011556213,0.060206022,-0.015569939,0.0142906485,-0.024963124,0.0035321517,-0.006463382,-0.043290343,-0.13109612,-0.037034344,0.01807369,-0.046198837,0.03615388,0.07033254,-0.051554926,0.062485002,0.025948152,-0.01344052,-0.099943325,-0.0074802614,0.15996887,-0.05050351,0.024713282,0.018872537,-0.04245361,-0.057886608,0.00085461955,-0.027895827,0.07874422,-0.04984432,-0.023720173,-0.0013146296,-0.0033572032,-0.014452785,0.0437035,0.07013211,0.09768617,-0.013872988,-0.021831153,0.03510389,0.04996327,0.019090692,0.004188683,-0.083245166,-0.016278336,0.010159281,0.047494568,-0.025635099,0.067963384,0.032135062,-0.015700173,-0.07953987,-0.073251724,0.046102908,0.05232085,-0.035368048,0.03474001,-0.011901491,0.002497031,0.0017991565,-0.041925292,-0.003441697,0.070059575,-0.07750416,-0.020083798,0.04037075,0.024461888,-0.049083993,-0.09121742,-0.083611146,5.151395e-05,-2.3197832e-33,0.02146912,-0.0036942721,-0.11741189,-0.03226536,-0.14568804,0.051234316,0.04442573,0.055544607,0.010346396,-0.03480717,0.1379506,-0.022674108,0.024742587,-0.08807967,-0.0074682827,0.048912752,-0.059746318,-0.00326226,0.00998033,-0.049583964,-0.01655927,0.032125458,0.0077070454,-0.039499607,0.009302367,0.0402762,-0.05321246,0.11658703,0.02467744,0.009866126,-0.03394973,-0.019075776,-0.04426467,-0.080218084,-0.057798795,0.029274987,0.0034479417,-0.020349013,-0.07298607,-0.078358926,-0.023748428,0.026309801,0.06964911,0.039107732,0.020952089,0.07595436,-0.08022278,-0.039488174,0.007036528,0.0041968566,0.051466525,-0.012221861,-0.017614055,0.02162753,-0.045732986,0.013467165,0.03794769,0.053775083,-0.0875787,0.11039322,-0.019004751,-0.0114504015,0.083500415,0.025770206,0.06699994,0.023540426,0.015337725,0.08136367,0.013627764,-0.0056167278,0.0758023,-0.0083513055,0.03828579,-0.0050784475,0.05903898,-0.006339878,-0.057334654,0.026544074,0.05158293,-0.087991655,-0.04850607,-0.020877404,-0.069654085,-0.03849668,0.087956965,0.02988982,-0.031395108,0.006158897,-0.032341573,0.043275043,-0.04535442,-0.10429268,-0.09915124,0.008328948,-0.07268305,-2.8393202e-08,0.046173453,-0.06035853,-0.0343868,-0.02742314,-0.019006236,0.014475119,-0.0441654,0.08350482,-0.028300716,-0.017860334,0.008567622,0.03649838,-0.050593514,0.053273603,0.0052870554,0.0036715914,0.045646477,0.023572098,-0.042528052,-0.05640986,-0.024409572,0.073253974,-0.044495545,-0.019331224,-0.00618626,-0.049276944,-0.020959232,0.025314188,0.09816576,-0.052708045,-0.010435125,0.0496469,0.057270054,-0.085006565,0.02652799,-0.013856444,-0.013785622,-0.0068192133,-0.051131975,0.017520534,-0.030028129,0.008441679,-0.03991119,-0.017723124,0.0074580675,-0.020449303,0.0044229086,0.0015675434,0.0030769939,0.043269005,0.050708875,0.021152208,-0.034731444,-0.026271809,-0.07247735,-0.05994204,0.038159963,-0.036671374,0.042521723,0.027367909,0.01457098,-0.068301246,0.061438642,-0.035251964 +3.4.22.25,"From the papaya plant, Carica papaya. Not inhibited by chicken cystatin, unlike most other homologues of papain, but in peptidase family C1 (papain family)",384,1.0,-0.102150545,0.010603944,-0.07310543,-0.031120462,0.02807211,0.09538562,-0.05325718,0.0027859472,0.047506776,-0.050661042,0.04409021,-0.02461526,0.00446192,-0.035037577,-0.057149477,-0.02646421,-0.037082497,0.010862659,0.017154137,-0.07456948,-0.060590107,0.03265456,0.034953687,0.061770678,-0.062873594,-5.9913986e-05,-0.007274477,0.051856168,0.059009217,-0.022638885,-0.04326281,-0.004629064,0.036862943,0.005081963,-0.033586726,0.026303655,0.0017423185,-0.047831327,0.07034683,0.0060380786,0.11468768,-0.0017418459,0.016837299,-0.09117729,0.097219124,-0.05512987,-0.09868174,0.020315384,0.015867453,-0.092616886,-0.07476895,-0.05144708,0.012875859,0.030325148,0.029577706,0.020561187,-0.027696474,-0.020870889,0.046359785,0.020284824,-0.039576273,0.009280766,-0.045569204,-0.009990709,-0.06168778,-0.090964474,-0.0454367,-0.011773039,-0.00308491,0.031487226,0.016585058,-0.030031351,0.009692281,0.037504163,-0.08783931,0.0844108,-0.01656447,-0.09349926,-0.112483695,-0.013532646,0.0681666,-0.023009509,0.034025118,0.08735202,-0.030958403,0.0007235677,-0.013604925,0.04461114,-0.036568303,-0.0015362885,0.0904191,0.0036623734,-0.031352896,0.0051616416,-0.059763703,-0.0001299077,0.040962268,-0.10520335,0.035020933,-0.009979655,0.066417985,-0.023776418,-0.06642718,-0.085185416,-0.052285828,0.067607746,0.0045533217,0.036079586,0.06455676,0.008452247,-0.061312385,-0.026340468,-0.09818671,-0.10316518,-0.12820226,0.01683453,0.019566258,0.010385341,-0.0069487626,-0.001572469,0.035272587,-0.033846006,0.045853913,0.048978273,-0.013616787,-0.0364268,-0.13975987,1.1099331e-33,0.02984679,-0.01596606,0.13615687,-0.0054392023,0.052822486,-0.012240665,-0.022799194,-0.053318545,0.054601934,-0.12861378,-0.034387473,-0.024574596,-0.06298377,-0.075172015,0.0044938363,0.03734945,-0.06738208,-0.09927366,0.0025308433,-0.028261721,0.05046412,0.031826206,-0.07364484,0.00649334,0.042809695,0.008762353,0.00066888554,-0.04607475,-0.026705807,0.0009725359,-0.04200984,0.011598302,-0.067853525,0.045402724,0.070024975,-0.008453102,0.040921655,-0.11604879,-0.040660046,0.06324877,-0.007232819,-0.09441761,0.060195412,-0.038455192,-0.017160242,-0.06385121,-0.041854955,-0.023269251,-0.03129939,0.06883741,0.07173478,-0.0640585,0.009731278,-0.044404056,-0.07634142,-0.0063423016,0.026047729,-0.011852915,0.041362736,0.1065436,0.024730872,-0.051865123,-0.020614028,0.01950955,-0.029442439,0.013120812,-0.10476524,-0.024967894,-0.040748633,0.08185999,0.010690702,-0.024305496,0.07773186,-0.024646755,0.05089344,0.013085708,-0.051636364,0.10723497,0.02795539,0.079594545,0.05103933,-0.011282777,0.0065327096,0.022489639,-0.029169455,0.008593229,-0.00014478565,0.038918395,0.04425821,0.02882323,0.015207157,-0.031744476,0.026515175,0.03003281,-0.06665009,-3.778961e-33,0.045661256,0.005066495,0.102277815,-0.017753929,0.009002271,-0.0017042526,-0.018284226,0.0021531032,0.030550994,-0.0548481,-0.006565657,-0.032147586,0.056752633,0.020369511,0.012589162,0.08366457,0.013360832,0.073030904,-0.11027644,0.017203797,-0.106793515,-0.07237437,0.032387003,0.07811119,0.083106466,-0.015478593,0.030022182,0.034254543,0.0021755446,0.0110783335,-0.050695565,-0.01901858,-0.09209026,-0.0580362,-0.006831522,0.029630845,-0.03642804,-0.013556017,0.0438335,-0.0073465337,-0.031897806,0.03146564,0.07218988,0.06394895,0.010699002,0.043187555,0.02060322,-0.015616252,0.0009742944,0.02183894,0.018968245,0.029829508,0.023452805,0.055773772,0.047598973,4.5124354e-05,0.037209284,0.085266635,0.034836493,0.03241916,0.079494596,-0.005770188,-0.083852716,0.028609943,0.07649605,0.03988723,0.023011982,0.058052693,0.0891297,-0.036758777,0.029459808,0.021220956,0.07528104,0.06548394,-0.0981633,0.06587295,-0.025052639,-0.07922226,-0.0009941651,-0.01419201,0.031658743,-0.054505043,-0.06455368,-0.0077155516,-0.042969506,-0.008654399,0.028035568,0.053302806,-0.024749784,-0.010803636,-0.0005566692,0.035513237,0.022509158,0.07846415,-0.035269022,-2.6843619e-08,0.022853624,-0.13637902,-0.010092274,-0.061930276,0.0064616892,-0.01962973,-0.017055953,-0.04115704,0.07909151,-0.052539498,-0.036578085,0.016928839,0.04504063,0.0052876617,-0.053481497,0.019238075,0.02044118,0.048535127,0.067355104,0.057831783,-0.09935806,0.02667441,-0.060756985,-0.014892128,-0.046396,-0.0383918,0.028459068,0.0837924,0.030675469,-0.037696272,0.007827773,-0.0062325555,-0.016419891,-0.07040949,0.011837082,0.069751315,0.0018445435,-0.03224276,0.0020253304,-0.050971042,0.067836784,-0.0031526634,-0.046572674,-0.023795366,-0.0356934,-0.013152993,-0.032795608,0.040994268,-0.014693236,0.008217678,0.022718413,-0.006304938,0.038423,-0.063698225,-0.008821905,-0.022491436,0.1071326,-0.029332627,0.06297976,-0.02245795,-0.018276703,0.015926352,0.16895741,0.11722225 +3.4.22.26,Apparently produced only by malignant and fetal cells,384,0.99999994,-0.027618675,0.039707635,-0.10872476,0.016825797,0.015857514,0.013666816,0.0076023573,0.01414263,0.0279683,0.09287936,0.0042668744,-0.02673013,-0.017967882,-0.060965385,-0.07610672,0.053936288,-0.031344786,0.0029215505,-0.021858728,0.046880662,-0.020966066,0.030660402,0.029680854,-0.0068254746,0.1017717,-0.02476834,0.0010314828,0.057694703,0.0014182094,-0.008056049,-0.0268085,0.007227128,-0.016378341,-0.01913298,0.02266009,-0.007801058,0.019517781,0.037266046,0.0736579,0.01975202,0.042307507,-0.087137945,-0.04802094,0.018123727,0.012810843,-0.00032545332,-0.064390756,-0.059859734,0.010830923,0.05227079,-0.030852417,-0.015213846,-0.046425253,0.050332017,0.011922528,-0.092040405,-0.100302435,0.00082632643,0.044611476,0.025866568,-0.027560983,-0.040679928,-0.008221373,-0.019871773,0.08992359,-0.023840725,-0.002076078,-0.049818024,-0.045887273,-0.022917181,0.06086427,0.0037262645,0.07093066,0.10973626,-0.043938994,0.014066939,0.07004248,-0.0020768854,0.077075265,0.04352193,-0.0012382591,0.036105346,0.030580526,0.06419676,-0.04301959,0.04030431,0.013758429,0.054114774,-0.026906272,0.068152666,-0.051199403,0.046971887,0.043571956,0.024921158,-0.03139916,-0.020278044,0.041304916,-0.05458884,0.08240439,-0.047830004,-0.04698834,-0.04530878,0.03806026,0.025240304,0.026686234,0.0110454615,-0.09913446,0.032888506,-0.06382375,0.07600264,-0.006693644,0.037413195,-0.044311732,-0.015244212,0.03667278,0.07579263,0.023064967,-0.07341301,-0.0403132,0.01021047,-0.012693737,0.016739054,0.010867471,0.10082573,-0.07439867,0.009003653,0.04463992,-4.4541318e-34,0.04383908,-0.02393601,0.07066248,0.058130622,-0.011952925,0.10079628,-0.015376604,-0.105011925,0.0612183,-0.05804145,-0.069463655,-0.073705144,0.07301807,-0.0015744261,-0.025471076,0.022738772,-0.04230226,-0.058175586,-0.006879147,-0.017135914,-0.09072618,0.050877664,-0.008005383,-0.101628944,-0.039752293,0.0026393835,-0.026799038,0.0073893843,0.014450264,-0.03130845,0.0050266245,-0.010294244,0.034521777,-0.017926583,-0.020927977,0.08414518,-0.053054713,-0.031664945,-0.008093525,0.13300847,0.03099835,-0.03969906,0.034335572,-0.041880596,0.006136585,-0.0236197,-0.092715666,-0.035936818,-0.008291316,-0.04016169,0.040192526,0.03545522,0.020012913,-0.028597686,-0.008808819,0.014304127,-0.061527617,-0.007774556,-0.009131002,0.07508308,0.042248875,0.036655,-0.033854242,0.07435347,-0.053823236,-0.06744393,-0.023129566,-0.036979493,-0.03064628,-0.014842152,-0.014166171,-0.09938444,0.07671923,-0.15734787,-0.00811151,0.023090389,0.00962345,0.06594537,-0.05563118,0.009382145,0.05383409,0.0069276034,0.0077070426,-0.013784981,-0.005718121,0.010737045,-0.0797026,-0.009787297,0.014528731,0.06817174,-0.051414628,-0.0968885,-0.08647373,-0.06754249,-0.04560822,-2.4023822e-33,0.015187095,-0.028831376,-0.009944495,-0.047030542,0.0019598678,0.023132186,-0.014260145,-0.032004844,-0.058420718,0.10473443,0.08032674,0.03633056,-0.021223886,-0.041679427,-0.01112425,-0.058007065,0.090856194,0.10061068,0.016110932,-0.00774988,-0.056698263,0.054899238,-0.060812052,0.049538534,-0.018396543,0.052615605,-0.032384682,0.10317585,-0.0072545535,-0.025566578,-0.006039351,0.039005544,-0.057253655,-0.0032985348,0.08432276,-0.06150772,-0.0019857625,-0.03661013,0.10333028,-0.09273344,-0.0076864455,-7.532996e-05,-0.0014753991,0.1467477,0.06787046,0.02410883,0.095603295,0.0078996755,0.018028498,0.019878779,-0.010964842,-0.006630391,-0.115157306,-0.05349059,-0.0645647,0.00046956842,-0.02508949,-0.05646338,0.102631345,0.012080048,0.0030533522,-0.011665208,-0.039490636,-0.10191736,0.017102987,0.114735484,0.0028488794,0.04766377,0.013506192,0.049414102,0.07075587,0.05934822,-0.07607882,-0.057443086,-0.05440242,0.040407043,-0.032640025,-0.006797951,0.06335131,0.02809462,0.004097762,0.0068823625,0.056429867,-0.044025164,0.058643438,-0.050788064,-0.01582224,-0.0024754638,-0.03994772,0.0050121546,0.01263265,-0.07928714,-0.094017565,0.022791697,0.0400585,-1.7152702e-08,0.13552499,-0.0341663,-0.013230281,-0.07925586,0.0006332651,-0.059521962,0.053839333,0.017920263,0.086378604,-0.008608088,-0.10101394,0.01874246,0.014134471,0.012826866,0.06752269,0.008602346,-0.040133633,-0.010055013,-0.0493428,-0.053908657,-0.0039068623,-0.021113731,0.054284528,0.09743003,-0.031809013,-0.021534216,0.01550618,-0.030301357,0.045289487,-0.03358693,0.067035206,-0.013259051,-0.0004530372,-0.050703324,-0.01425542,-0.024945537,0.03312442,-0.068103984,-0.0062040216,-0.06854459,0.0020021577,-0.019465124,0.01417225,0.030202935,-0.010481341,-0.023662409,-0.05116149,-0.053748764,-0.023798842,-0.057943393,-0.013317834,-0.017330151,0.0047185807,-0.038423374,-0.071816266,-0.017724859,-0.03227043,-0.031810913,0.029565098,-0.0033634633,0.076485984,-0.039487217,0.2386535,0.04706201 +3.4.22.27,A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family),384,0.99999994,-0.03472802,-0.07284793,-0.06772517,-0.052622683,0.12193661,0.059829433,-0.07463358,0.09266179,0.03963271,0.040860776,0.066445574,-0.015795149,-0.046471134,0.048089635,-0.06690127,0.00083752733,-0.09834298,-0.024818206,-0.04387376,-0.05789867,0.009033124,0.042391367,-0.004812237,0.043119986,-0.050783705,-0.021122362,0.012388662,-0.07205979,-0.028546976,-0.044005733,-0.0019326904,-0.07555563,0.018812314,-0.018133176,0.05442669,0.07166231,-0.028676173,-0.014480569,0.059390843,-0.04588194,0.052012455,0.030239407,-0.028901538,-0.062399082,0.006405963,0.054991618,0.013576385,0.066950515,0.04653974,0.037924666,-0.018716663,-0.11190265,-0.011904529,-0.047085818,-0.032419924,0.06514917,0.024261203,0.0146173155,0.04099346,0.06317709,0.025708659,-0.031900615,-0.037854124,-0.035745975,0.015303406,-0.096382074,0.041994408,-0.04791779,-0.009903014,-0.026243297,-0.016677465,-0.0502511,-0.051440354,0.05963204,0.023166098,0.10856869,-0.048497297,-0.063400574,-0.11057105,-0.0073334766,0.06083339,-0.041194085,0.044431463,0.057275657,0.04468348,-0.03982296,0.002505024,0.05818576,0.046945017,-0.03037997,0.029352546,-0.04693943,-0.015395597,0.025249928,-0.029944291,-0.011611905,0.024326622,-0.057101514,-0.017232798,-0.034592684,0.044516828,-0.014170659,0.0122113135,-0.08500347,-0.015258521,0.052416418,-0.017276386,0.04739586,0.07512566,-0.06492742,0.026613321,-0.017800435,0.022852978,-0.10735326,-0.0024361513,0.02357023,0.024256745,-0.016392812,-0.05083342,0.04101753,0.07609765,0.050772984,0.028407281,0.037486326,-0.030539794,0.03798339,-0.0671884,-2.8093548e-34,-0.007490671,0.02866203,0.03177603,-0.016416771,0.008823852,0.022786971,-0.032436814,0.03240282,-0.02310316,-0.05360051,-0.007907397,-0.06062023,-0.018545227,-0.072563805,-0.065378964,0.024094023,-0.009628501,-0.043162957,0.0094108,0.029946754,0.016491018,-0.014063763,-0.05221675,-0.02902365,0.097175896,0.083386205,0.021596067,-0.014967689,0.04100823,-0.0011768565,-0.045469802,-0.036050268,-0.08758325,0.009363119,0.027609844,0.0059689116,0.052916013,-0.088060334,0.02019414,-0.017404428,-0.06489943,-0.026035106,0.0023111026,-0.038407408,0.047000036,-0.10301805,-0.025013136,0.038585097,-0.032505937,0.027783837,0.006091473,-0.10145472,0.078320846,-0.00143899,-0.04365655,-0.007989567,-0.002622338,0.030577911,0.06148754,0.05857694,0.10266306,0.040163536,-0.10239558,-0.018553434,-0.05422687,-0.013313837,-0.051979482,-0.01839406,-0.02661191,0.1062888,-0.018721217,-0.0026317702,0.09040477,0.016770191,0.026159031,-0.061181877,-0.078620896,0.09134137,0.037528243,0.04463169,0.07294353,0.04689398,0.00087864633,-0.0083360765,-0.034962237,-0.022403458,0.009117682,-0.0049928497,-0.13588727,0.05122262,-0.013020098,-0.04285083,0.043402795,0.10216551,-0.09374814,-1.4782159e-33,0.060436774,-0.04466309,-0.010766833,-0.03273102,-0.030658541,0.03809031,0.014037155,0.014809508,0.020458339,-0.070418134,0.05083034,-0.100576945,0.023374284,-0.004423962,0.035566226,0.018673075,-0.009884013,0.08310787,0.056987423,0.0076723318,-0.06465129,0.013788419,0.024577806,0.050436683,0.123473465,-0.010052322,-0.08016435,0.0795092,-0.010341006,0.070082545,-0.043474663,0.00011727657,0.0062968885,-0.055284694,-0.04124087,0.07418193,-0.10781414,-0.045921303,0.10511636,0.06710688,-0.029020688,0.0015640351,0.100912884,0.06991165,0.036290325,0.042080298,-0.032608148,0.04517317,-0.008158746,-0.06704261,-0.008251628,-0.01748604,-0.012680148,0.048212796,-0.0080570765,0.01854152,0.0065125157,0.100434735,-0.006736267,-0.039791778,0.009317759,-0.048432954,-0.048232168,0.09181829,0.03656556,0.029517082,-0.06749728,0.003209475,0.07995168,0.020620812,0.01858246,-0.044991326,0.07015463,0.053372912,-0.014054969,0.054256584,-0.07912748,-0.049201064,0.040218923,-0.012474167,-0.05678358,-0.020848991,0.0070561185,-0.022813953,0.04205087,-0.11598808,-0.012639302,0.055832103,-0.014231824,0.030530944,-0.02478016,-0.027033452,0.06935874,0.04073649,0.07207356,-2.645763e-08,0.11864615,-0.06260033,0.018482806,-0.10553328,-0.010781222,-0.06130884,0.02879398,-0.046822466,0.016954843,0.011969968,-0.017461462,-0.008160466,-0.010906495,0.049769215,-0.022070786,0.09855334,-0.023994172,0.08369282,0.037110306,0.043637436,-0.07511487,0.029572418,-0.100119665,-0.036842626,-0.018128002,-0.017345214,0.045837335,0.026309958,-0.043064192,-0.00792234,0.04357881,-0.0072067864,-0.040575758,-0.03226486,-0.04088075,0.10254864,-0.061536565,0.0111216875,0.013213075,0.0028340535,0.009296891,-0.024949752,-0.119655274,-0.02015087,0.008831622,-0.04407629,0.10125786,-0.008470951,-0.006155053,-0.019052273,0.028580328,-0.039837595,-0.015932152,-0.058186293,-0.026661469,-0.012401824,0.047407243,-0.043432895,0.015770763,-0.11650879,0.012201779,0.06431557,0.16312586,0.0031509514 +3.4.22.28,"From entero-, rhino-, aphto- and cardioviruses. Larger than the homologous virus picornain 2A. Type example of peptidase family C3",384,0.99999994,-0.005762433,-0.00479539,-0.09020618,-0.029507283,-0.007703737,-0.0340271,-0.0065518506,0.045224458,0.017034464,0.051416107,0.047973733,-0.013398542,0.0077972524,0.08341741,-0.009754462,-0.062009465,-0.11559756,-0.03685714,0.01218873,0.025877561,0.005504861,0.043933056,0.010437883,0.04735296,-0.14045723,-0.041291293,-0.007013922,0.03595359,0.033342082,-0.053157326,-0.07044872,-0.028777126,0.15077652,0.006768296,0.033489,0.03781916,-0.015210735,0.003306005,-0.0059335916,0.044140834,0.0118025355,0.06995402,0.10009413,-0.0041867946,0.050573472,-0.026038546,-0.09220788,0.05597268,0.048662342,-0.073528245,-0.019935595,-0.041711792,-0.07000931,0.03226247,-0.004816649,-0.04995033,-0.103833534,-0.0832681,0.0120817255,-0.013825239,-0.005620466,0.09581161,-0.0009879499,0.030523693,-0.08293164,-0.031955194,0.07563631,0.024795365,0.0052289846,0.022578506,-0.014913647,-0.034473013,-0.06563582,0.084769815,-0.039640006,0.0896804,0.016041191,-0.0035710752,-0.041415285,-0.05851839,-0.06861535,-0.01927083,0.07704973,0.04941985,-0.04634962,0.019506337,0.021902116,-0.017420586,0.00084675674,-0.028103156,0.023802394,-0.04664565,0.05273941,-0.005547204,-0.045036077,-0.027207308,0.07293501,-0.055549648,0.013984179,0.020547232,0.015863897,-0.078213036,0.024216246,-0.012941518,0.031069973,0.0453491,-0.011940431,0.017006438,0.12195237,-0.010863549,-0.06947436,0.039692484,-0.0004106097,-0.09196959,0.022438535,0.009733577,-0.06599816,-0.016095629,0.033311445,0.056077395,0.032203894,-0.03623959,-0.0075717443,-0.057396494,-0.07660725,0.010568033,0.018634899,1.3189215e-33,-0.011314933,-0.025220446,0.0691454,0.0793223,0.019643521,0.02115048,-0.07469426,-0.05688264,-0.02226574,-0.024282362,-0.082357556,-0.02284663,0.041269112,0.055565894,-0.04653957,0.008711862,-0.07222801,0.060841125,-0.08185008,0.08292579,0.054823406,0.10907818,0.035577763,-0.061382502,0.09372837,0.03100639,0.009225276,-0.0436729,0.01916211,-0.02882326,-0.00028741825,0.0051809913,-0.06686802,0.03126251,-0.051396076,-0.041944314,0.028091112,-0.0891467,-0.024485283,0.0056610922,0.09273504,-0.03364061,-0.080617204,-0.009201503,0.0971079,-0.07567579,-0.010119935,0.013892887,-0.058982402,0.03950215,0.020251015,0.03825364,0.026021877,0.01568832,-0.073164016,-0.045736164,0.018227424,0.026897391,0.09511625,0.013896138,0.050194513,0.059267297,0.03635245,-0.0019221023,-0.06608938,-0.051387265,-0.052823465,-0.003812939,-0.034026384,0.13499492,0.031535417,-0.017281381,-0.019737545,-0.04071009,0.05715516,-0.039332658,-0.043874793,0.0049600853,-0.07356503,0.02127931,-0.08321492,-0.009750386,0.13288803,-0.0054820185,-0.058162104,-0.026218357,0.022120204,-0.026829168,-0.045015343,0.051138967,0.015616466,0.089159966,0.0064511923,-0.010972094,-0.013775071,-3.0553859e-33,0.017610583,-0.0069913995,0.015430527,-0.12092772,-0.073542796,0.09491335,0.052893534,0.04548641,0.03507826,-0.09383433,-0.008200132,0.032067083,0.048432317,-0.118132904,0.045980625,0.037641197,0.06372503,0.06464598,-0.031171985,-0.006082855,-0.036039818,-0.057127215,-0.04631126,0.019628085,0.029251972,0.019337634,-0.0118712615,0.07654767,-0.0524069,-0.08800352,0.0021718757,-0.011122778,0.008911688,0.08393771,-0.04546032,0.002959197,-0.0083780475,0.024964076,-0.03571625,-0.03579474,-0.020333307,0.067200765,0.051053807,0.10031064,0.00039696522,0.054298937,-0.005662498,0.047844335,0.049832165,0.025847403,-0.0146809295,-0.114105396,0.026714792,0.024584431,0.03136828,-0.029780565,-0.051771104,-0.010491747,-0.01904148,0.045224868,-0.00070960674,-0.045338888,-0.028665932,0.041124195,0.07926325,0.034645226,-0.055143427,-0.013927377,0.05097892,-0.022924805,0.05262542,0.06769123,-0.011554294,-0.0148769645,0.008430706,0.060547747,0.012603101,-0.04999587,0.012041506,-0.086205885,0.034975033,-0.025048358,0.058875415,0.011442994,-0.018152421,-0.019614356,0.030379787,-0.036341455,0.019429615,0.041759133,-0.01616863,0.023738034,0.052538518,-0.0075763827,0.06739023,-2.9397357e-08,0.10843331,-0.044798363,-0.0020794857,0.0045619668,-0.037755236,-0.019854944,-0.0673786,8.22994e-05,0.06571681,0.053657588,0.053202476,0.034350272,0.038343184,-0.015566968,0.05365909,0.060843073,-0.11884459,0.039606683,-0.036796078,0.05906747,-0.09103658,0.007027788,-0.052069016,0.012009671,-0.0035142375,-0.03983694,0.0126507785,0.019318538,0.02196582,-0.060170665,-0.0108196195,0.0021598109,-0.037692167,-0.019247526,0.029041264,0.0014550826,0.0028961522,-0.016286684,0.016531117,-0.043925054,0.08070978,-0.073715866,-0.018740518,-0.076748095,-0.0086013945,-0.06709628,-0.09625639,0.0010337556,0.01134506,-0.034964517,0.027443798,0.0687097,-0.017610606,-0.064715,-0.12009371,-0.05334028,-0.017161498,-0.04750671,0.056208983,-0.051359463,0.011754513,-0.056509092,0.16240673,0.1032641 +3.4.22.29,"From entero-, rhino-, aphto- and cardioviruses. Smaller than the homologous picornain 3C, which is also in peptidase family C3 (picornain 3C family)",384,1.0,0.01105215,-0.00061639637,-0.11272918,-0.0031843565,0.0065183267,-0.05371262,0.0022836626,0.042397,0.03324944,0.046866834,0.060731724,-0.054708853,-0.011546154,0.07415707,-0.014138785,-0.058597103,-0.08977751,-0.04715449,-0.0009795377,0.023142975,-0.026496967,0.052538753,0.060983185,0.05225079,-0.13001566,-0.063674524,0.00865323,0.052668486,0.021703186,-0.067634985,-0.07936982,-0.01815349,0.14303145,-0.000968573,0.014057882,0.04230206,0.0041704467,-0.014433383,0.008846211,0.03451108,0.0053054783,0.06529731,0.10962085,-0.008429485,0.013961308,0.007947208,-0.103877075,0.043379687,0.031464163,-0.04192716,-0.008501939,-0.04128755,-0.11254884,0.057833258,-0.0030104965,-0.045985345,-0.10858669,-0.10962757,-0.021930851,0.017915614,-0.0011185912,0.07552984,-0.0094519295,0.047746908,-0.07266796,-0.01521157,0.092374116,-0.0086687,-0.0019803992,-0.027022736,-0.005714534,-0.027433008,-0.029232796,0.09634978,-0.051486973,0.099783525,0.010590082,-0.0015175026,-0.04217265,-0.06869172,-0.060320444,0.019491646,0.022209862,0.060039904,-0.015467129,0.030868229,0.019114286,-0.02393284,-0.037743565,-0.04127124,0.029170142,-0.021431196,0.024780916,-0.016051983,-0.032255724,-0.031991806,0.07789485,-0.028967941,-0.0021027562,0.010023668,0.01876313,-0.06042598,0.026807139,-0.023346696,0.0323503,0.06111075,-0.0077098017,0.03706408,0.13497102,-0.017846584,-0.09241456,0.045860782,-0.0010572877,-0.06302307,0.012903669,-0.0052304864,-0.047790285,-0.04940332,0.050847743,0.06436677,-0.015931537,-0.022309363,-0.021404037,-0.05796628,-0.05081236,0.008082877,0.00019984237,1.6605874e-33,-0.0034825904,0.0120709855,0.06667318,0.07387657,-0.005892099,0.022384401,-0.07012002,-0.07875407,-0.06284395,-0.022512639,-0.09459711,-0.05581091,0.061479516,0.031846825,-0.009422417,-9.525821e-05,-0.087068595,0.05754517,-0.091053836,0.07530583,0.008082169,0.10651394,0.023381807,-0.047258522,0.06933167,0.04252214,-0.024006939,-0.04122102,0.0030310785,-0.03524112,0.011390542,-0.0033898554,-0.045255583,0.01893314,-0.027615301,-0.032529727,0.017798057,-0.12016724,-0.02653611,0.030478528,0.09450595,-0.0436954,-0.07388778,0.0033509082,0.054029707,-0.077932276,-0.00048766358,-0.0053244373,-0.04991892,-0.000112207985,0.050457038,0.055634793,0.03250098,0.005000696,-0.06555604,-0.05769468,0.012486203,-0.0065482375,0.07895305,0.03403852,0.04472919,0.043996487,0.013669878,0.030362736,-0.033832774,-0.014695511,-0.06790263,0.0060831513,-0.032560535,0.10060398,0.049444195,-0.027466865,-0.008938837,-0.051920958,0.07601426,0.001019591,-0.026850855,-0.0314096,-0.0696651,0.023026265,-0.08900934,-0.00035462165,0.09873892,0.00088129746,-0.07645236,-0.022765517,0.054456465,-0.022489602,-0.037068803,0.041650526,0.021048719,0.09082474,-0.007943354,-0.04518743,-0.002468366,-3.443532e-33,0.03447316,-0.025067598,0.03639881,-0.13424653,-0.07976697,0.08471363,0.06302329,0.10329138,0.04807062,-0.07961767,0.022994556,0.037667006,0.054040246,-0.14436443,0.060197067,0.049721148,0.068361446,0.0396079,0.012839501,-0.018884346,0.008496866,-0.048553187,-0.03211507,0.029629573,0.012522704,0.044988062,0.011354536,0.04721599,-0.05751503,-0.092821755,-0.0019436781,-0.038054895,0.00989128,0.09003525,-0.038554993,-0.021529084,-0.025118334,0.0018968635,-0.06023287,-0.028541345,-0.028013166,0.039105587,0.026514666,0.11790057,-0.008406193,0.055355333,0.009990928,0.060470723,0.041782912,0.051902432,-0.006588639,-0.09640387,0.042717207,0.0337579,0.03983829,-0.00651903,-0.05506949,-0.046930864,0.02208785,0.033433814,-0.008013605,-0.028912732,-0.03673035,0.031842597,0.066302024,0.065134,-0.051699474,0.0009893037,0.039704002,-0.0345304,0.07620999,0.06650028,-0.015454952,-0.023895843,-0.003912501,0.029360624,0.015646556,-0.030598965,0.015108727,-0.053115778,0.039086685,-0.03485772,0.043488126,0.006955092,-0.019177914,-0.016754579,0.043131012,-0.041052554,0.025808437,0.021557,-0.04708488,0.062402304,0.015333285,-0.033834238,0.062230505,-3.1261596e-08,0.10535413,-0.045453157,-0.020481128,-0.003439145,-0.044030067,-0.0009871415,-0.0403191,0.032270133,0.056336667,0.10516762,0.089221925,0.046344828,0.03945732,-0.041565947,0.047661208,0.01829195,-0.09269954,0.038842287,-0.013473799,0.035364218,-0.08919792,0.014068811,-0.014933479,0.0014724388,-0.025294142,-0.045365192,0.030476565,0.021634348,0.0071842014,-0.06844397,0.0066608293,0.0066755153,-0.009664542,-0.0010778523,0.012876609,0.013331155,0.001314097,-0.004520885,0.0074484674,-0.020589093,0.054711785,-0.057337016,-0.023842238,-0.049711805,-0.040840015,-0.061750986,-0.079389594,0.029302726,0.027749753,-0.049272664,-0.00083141314,0.06590402,-0.017568594,-0.057159167,-0.13478985,-0.081684195,-0.030474152,-0.05663661,0.0061614704,-0.03295107,-0.018325869,-0.062567845,0.16539936,0.09479231 +3.4.22.30,"From papaya plant, Carica papaya. In peptidase family C1 (papain family)",384,0.99999994,-0.044334054,0.05956435,-0.11085086,-0.03999863,0.008044331,0.04816197,-0.06568642,0.009925389,0.022657076,-0.050376054,0.09415008,-0.079546526,-0.008962873,-0.10153004,-0.037205175,-0.032106988,-0.047055572,0.018901862,-0.041939776,-0.12788402,-0.017726168,0.029231291,0.001996441,0.040763,-0.06301025,0.022387063,-0.005507747,0.0021538853,0.10750545,-0.074715026,-0.030391758,0.02077165,0.09565702,-0.022720283,0.02021602,0.021339111,0.018204348,-0.0570948,0.07414991,0.027369268,0.096275724,0.023508795,0.03895522,-0.10452557,0.043522246,-0.02749504,-0.08534914,0.07892481,0.09244201,-0.08439604,-0.046888348,-0.058945607,0.0047851712,-0.014022039,-0.003954865,0.007736362,0.01612033,-0.030177703,0.043064594,0.08486809,-0.0035925752,0.029277915,-0.04820678,-0.008429207,-0.06695434,-0.08692152,-0.0063546477,-0.037950717,0.014027945,-0.034754615,-0.003192118,0.002912687,0.03830276,0.040190995,-0.10707656,0.019885115,0.0033170443,-0.0659738,-0.09045074,0.048154544,0.019816482,0.037026376,0.020967457,0.047654673,-0.053023443,0.020933285,-0.034374755,0.031787623,-0.011717004,-0.026645908,0.0042905207,-0.029153991,-0.013368887,0.046171345,-0.15247466,0.024549479,0.06861951,-0.09718613,0.037408754,-0.0005256251,0.034735963,-0.04555222,-0.011503606,-0.05154708,-0.12662308,0.052823704,-0.059210915,0.06824757,0.07176131,0.061891843,-0.061583217,0.024092108,-0.12121469,-0.102295555,-0.13505296,-0.017845608,0.011819093,-0.014784654,0.014242626,0.018068895,0.0007566753,-0.0037186828,0.015299369,-0.010917662,-0.022171352,-0.07835024,-0.047462616,1.2792805e-33,0.006198514,0.024812432,0.1327827,0.012897009,0.040671714,-0.009951071,-0.031726703,-0.030478224,0.032547574,-0.11270909,-0.061924845,-0.05080015,-0.095777825,-0.08367853,-0.008839527,0.032006014,-0.10288881,-0.050967373,-0.027787395,0.007987396,-0.015216125,0.057776976,-0.038835358,-0.007807082,0.05579127,0.023452366,0.030620683,-0.08331121,-0.019525569,0.013402152,0.050322883,0.019359939,-0.051524654,0.016752072,-0.011118806,0.025350349,0.028112333,-0.09076098,-0.05730906,0.055729944,0.064864315,-0.01847905,0.086657755,0.0035540885,-0.036770876,-0.047469113,0.043231275,-0.010463898,0.040235415,0.07912841,-0.0004848616,-0.011945484,0.01892814,-0.015238588,-0.06974318,0.00336345,0.04531504,-0.013746267,0.050873276,0.09365914,0.09045475,-0.008555695,-0.023494579,0.022223445,-0.043066334,0.0035427548,-0.084511705,0.038131755,0.041616432,0.04581209,-0.013016507,-0.050242696,0.06999688,-0.0014288456,0.046382263,0.019119507,-0.0065776133,0.04522678,0.0050988253,0.038970556,0.011587028,0.028469587,0.04362666,0.008084008,-0.038271636,0.021001237,-0.061110985,0.043795675,0.0018366579,0.05452342,-0.05141514,0.01844771,0.044522643,0.019328224,-0.048539307,-3.5178498e-33,0.050012708,-0.038030215,0.092154935,-0.021073418,0.040385738,-0.009665165,-0.034223057,0.04816035,0.00084147614,0.014183423,-0.007745433,-0.0064808927,0.065703996,-0.032967974,0.0020786058,0.120569065,0.07230732,0.118140735,-0.10152432,-0.014368412,-0.07967376,0.004346143,-0.020525228,0.014640858,0.048788957,-0.018410364,0.051999174,-0.0033696676,0.001397835,0.0032267387,-0.0120483935,-0.08194847,-0.10059141,0.021686098,-0.040003996,0.014642603,-0.042312853,-0.027103668,0.04628041,0.0542587,-0.029491613,0.054062884,0.07598208,0.059065085,-0.01515879,0.002032691,0.012359492,-0.023307836,0.036441933,-0.008701113,0.03919199,0.00038239924,0.022561112,0.0699409,0.007900027,-0.033819396,0.028052438,0.10296397,-0.0189214,-9.837e-05,0.057865545,0.0038905495,-0.103863046,0.049598172,0.0632603,0.032980323,-0.009503631,-0.008614417,0.02969365,0.008307104,0.019689413,0.027228374,0.035049837,0.052567374,-0.08294231,0.06721407,-0.046595115,-0.0848139,-0.027545739,-0.016887184,0.0399541,-0.08635303,-0.0338188,0.0142536545,-0.03234722,-0.041756574,0.028284254,-0.0045848945,0.029271724,0.03369638,-0.023762781,0.0820644,-0.016812349,0.046799626,0.000968143,-2.0920416e-08,0.040917426,-0.11055728,-0.021894937,-0.008206966,-0.014306715,-0.032043103,-0.030652838,-0.027991269,0.065432504,-0.033142064,-0.051540624,0.02662637,-0.0050586606,0.0191083,-0.008105681,-0.00537637,0.0138810035,0.07897164,0.08021107,0.045174547,-0.08983978,-0.0023521385,0.022903236,-0.031479307,-0.035141084,-0.0071288715,0.040529277,0.071303956,0.055580705,-0.014343839,0.012509855,0.0094655445,-0.031097226,-0.094811164,0.024973638,0.054921456,-0.018523972,-0.03502386,-0.06795553,-0.052275002,0.12004933,-0.021083226,-0.06266656,-0.02387723,-0.030674983,0.03535123,-0.050582685,0.053525936,-0.029975858,-0.029441204,0.02194467,-0.012473287,0.016627561,-0.026269363,-0.052837297,-0.048224144,0.055873413,-0.053793933,0.09387704,-0.010016717,0.034200605,0.07844989,0.13244718,0.09601047 +3.4.22.31,"From stem of pineapple plant, Ananas comosus. Differs from stem and fruit bromelains in being inhibited by chicken cystatin. In peptidase family C1 (papain family)",384,1.0,-0.04740228,-0.010193368,-0.041079756,-0.0036505626,0.033380263,0.09040932,-0.0071805287,-0.023168355,0.0644881,-0.003303947,0.10706475,-0.049502935,-0.0072712274,0.015191429,-0.077913836,0.053768996,-0.027074622,-0.03651226,-0.013047573,0.00351484,-0.023319453,0.06380995,-0.038869765,0.09901266,-0.01685293,-0.04111519,0.015791731,0.0015535752,-0.0004055418,-0.037312336,-0.0072754673,-0.030389741,0.114669,0.074345015,-0.027484063,-0.016356122,0.050041687,-0.04741889,0.12703863,0.026242882,0.029817233,0.06496496,0.05664088,-0.01694307,0.04763214,0.0016103978,-0.0782384,-0.0045564147,0.039257172,-0.059465244,-0.08711307,-0.08000097,-0.0559661,-0.0015367726,0.06661748,0.033299793,-0.03363824,-0.073185116,0.030986724,0.0401316,0.024017135,-0.046900652,-0.05428289,-0.04841047,-0.108716704,-0.05996594,0.013197942,-0.0061792643,0.017311284,-0.01528998,0.030553581,-0.038794793,-0.013204529,0.061912715,-0.09100249,0.0847659,-0.012138986,-0.07314004,-0.11735684,-0.046416305,-0.02727748,-0.02140756,-0.019464627,0.053909894,0.0016704026,0.011981113,0.031567227,0.04370662,-0.038124867,0.058400784,0.069233984,0.023358427,0.018549297,-0.00034118356,-0.046442017,-0.02174862,0.009659326,-0.06780341,0.017687516,0.010311895,0.05653251,0.0022941187,-0.020813819,-0.12017485,-0.0437909,0.075402126,-0.0024145902,-0.038869206,0.09450753,0.020931145,-0.08646559,-0.016895726,-0.079493135,-0.031891078,-0.06954015,0.06125258,0.028947257,0.017462278,-0.038130432,-0.0045655537,0.042367674,-0.010291006,0.079237424,0.02200653,-0.03489976,0.019070229,-0.1293583,2.0125727e-33,0.019612458,-0.031981133,0.0625877,0.03737111,0.042050224,-0.006935144,-0.06948443,-0.068946086,0.08117089,-0.11127092,-0.140382,0.00800179,-0.044464353,-0.050367318,-0.022262078,-0.008657792,-0.053695854,-0.04798338,-0.045628715,0.013774421,-0.056830995,0.008048074,-0.117976874,-0.03174244,-0.011787545,-0.04992042,0.04232687,-0.014927672,0.05209313,-0.018558366,0.0076061524,0.008860033,-0.055197816,0.006473791,0.059722017,-0.013186244,0.053084776,-0.062110946,-0.024176408,0.03383681,0.040661,-0.035672434,0.08042212,0.037063435,-0.003265017,-0.07320567,-0.0718457,0.029789727,0.02088152,0.031644307,0.033857983,-0.049767982,0.05912521,-0.05789185,0.005235205,-0.047195546,-0.01872689,0.04057608,0.05651021,0.09601501,-0.03280294,-0.039116867,-0.014202049,0.037346385,-0.025793558,0.056970943,-0.12419542,-0.036891334,-0.05282458,0.040918175,0.041626655,-0.05974093,0.044772472,0.012348536,-0.04674726,-0.066791095,-0.046111003,0.09972929,-0.046138376,0.065264046,-0.009362104,0.011621424,0.02203863,0.030517217,-0.051218804,0.056674663,0.02207402,0.04674734,0.07016292,0.04402543,0.04370828,0.0037379267,-0.0009582482,-0.010415454,0.0014008273,-3.319927e-33,0.020673184,-0.03507865,0.022078753,-0.048619922,-0.036741413,0.04174112,0.02892643,0.007169966,-0.017422473,-0.1367788,-0.0071082893,0.045242254,0.03336098,-0.024431286,0.026125342,0.025927568,0.081657656,0.0719151,-0.091654696,-0.0052076355,-0.106795855,-0.016665323,-0.0133265145,0.024039287,0.064021595,0.050561782,-0.019961737,0.07653919,-0.023623342,-0.005727283,0.0075081163,-0.013968703,-0.0812899,-0.0435891,-0.049432978,0.035197563,-0.03197411,-0.077594824,-0.011703401,0.008308549,-0.06285602,0.06796927,0.03844863,0.11952901,0.0088626,0.04987398,0.038649898,-0.019054841,-0.038423013,0.031816356,0.015159637,-0.020968003,0.06649423,0.028365294,0.060063448,-0.04929818,-0.024010897,0.021161119,0.020789597,0.022986319,0.04061611,0.04194537,-0.035475597,-0.016911935,0.022288634,0.043187,-0.022105267,0.026651917,0.040234134,-0.029399687,0.01777711,0.057759963,0.026013663,-0.034963198,-0.07346675,0.057660647,-0.02915593,-0.03750137,-0.086393,0.0011943411,-0.004615383,0.010905148,-0.06493115,0.022497518,-0.10572247,-0.0004476156,-0.0025200578,0.05645151,0.013784035,0.01076525,-0.04840567,-0.0005936864,0.016828783,0.1354047,0.026065204,-2.526759e-08,0.025572242,-0.08636743,-0.0011596072,-0.047499727,-0.022225302,0.025029846,-0.04035415,0.0035612828,0.041827623,-0.072140984,-0.08933503,0.056320474,-0.0042318585,0.072006136,-0.071010135,-0.008817329,0.027236523,0.09432214,0.045567766,0.0899231,-0.07773156,0.044331092,-0.045603756,0.04245815,-0.05157462,-0.029899277,0.056203317,0.11795223,0.021161629,-0.030320156,0.075223505,0.024949025,-0.036590062,-0.0492867,0.0025807046,0.017498072,0.021039484,0.018375032,0.007973356,-0.02510266,0.04715788,-0.05087534,-0.10071779,-0.015805982,-0.039198343,-0.041548926,-0.025975028,0.04860363,0.0025985963,0.036938347,0.032259114,0.024480194,0.031286098,-0.0144404,-0.027475342,-0.027070297,0.11587297,-0.046563175,0.05758349,0.019281108,-0.05011293,-0.033055287,0.16367044,0.106523305 +3.4.22.32,"The most abundant of the cysteine endopeptidases of the stem of the pineapple plant, Ananas comosus. Distinct from the bromelain found in the pineapple fruit (EC 3.4.22.33). Scarcely inhibited by chicken cystatin and also very slowly inactivated by {glossary/E64::E-64}. In peptidase family C1 (papain family).",384,0.99999994,0.015139371,-0.014145072,-0.024661185,0.01790987,0.06969132,0.11463124,-0.0042776912,0.030644437,0.055455483,0.012988536,0.100609474,-0.02644795,-0.015841521,0.022761194,-0.078107506,0.04722092,-0.015584007,-0.040527128,-0.0009150622,-0.0060364865,-0.044198055,0.046295445,-0.036740184,0.10488703,-0.012894234,-0.037178673,-0.005718655,-0.058705755,-0.06320165,-0.021425428,-0.022406567,-0.076490365,0.09448437,0.07405437,-0.00029705928,0.01630972,0.044774853,-0.059497897,0.10371288,0.008800713,0.0026067225,0.072574675,0.048070543,0.024102466,0.018110437,0.04355177,-0.017545253,0.006985815,0.04101858,-0.018546559,-0.07467832,-0.10412826,-0.008997716,-0.026336271,0.07112331,0.026698412,0.0010699015,-0.107802235,0.011679347,0.03372706,0.051863354,-0.043795824,-0.07247418,-0.07262749,-0.057807997,-0.09875152,0.029319767,-0.011542904,-0.005773027,0.012250016,0.042724214,-0.030440416,-0.07741732,0.049929388,-0.058647335,0.102142416,-0.09730145,-0.09910231,-0.111087374,-0.03917779,0.03113121,-0.021766948,-0.012240362,0.075893976,0.048380904,-0.007977039,0.049171977,0.07798262,-0.038212284,0.07973921,0.0481301,0.025625382,-0.037852194,-0.011029208,-0.02795507,-0.03533384,0.014188945,-0.06486764,-0.014842572,1.3835464e-05,0.03562344,-0.004020986,0.0072357804,-0.1305696,-0.061888427,0.056525994,-0.013121434,-0.021335585,0.08972766,-0.0048752283,-0.038892105,-0.033485964,-0.090237215,-0.044384792,0.017408978,0.078820676,0.040115166,0.040087666,-0.07088065,0.03554405,0.03998596,0.03866837,0.06639569,0.07624798,-0.056064922,0.033668887,-0.074326724,2.17208e-33,0.033400573,0.012036356,0.050047625,0.045045823,0.029715957,0.013511247,-0.056785043,-0.009767817,0.07368037,-0.07039609,-0.12790424,-0.018973555,-0.03878689,-0.063188255,-0.039272387,-0.027127152,-0.05307361,-0.03695707,0.010287921,-0.010621645,-0.06739825,0.0056661936,-0.10477976,-0.024991319,-0.0061728484,-0.0072756703,0.052947484,-0.025157897,0.072592236,-0.008063455,0.017428488,-0.0064371387,-0.08166685,0.0064559462,0.06159438,-0.015520958,0.053347033,-0.05949609,-0.021140981,0.029271847,0.034811318,-0.03393544,0.055551782,0.008645933,-0.00502881,-0.11430423,-0.0624189,0.041993383,0.017845731,0.032347646,0.022919724,-0.048358552,0.045396622,-0.047576763,-0.0378481,-0.049550485,-0.027346952,0.06767961,0.04946455,0.095110714,-0.018996758,-0.005251896,-0.04275585,-0.030194888,-0.06277393,0.055569082,-0.10861966,-0.052028764,-0.05029005,0.039127275,0.049270645,-0.09074393,0.0762627,0.018321166,-0.052077286,-0.03541567,-0.051224187,0.09550435,0.00026476546,0.034473356,-0.027915027,0.023533093,0.011349321,0.027475048,-0.017140513,0.06862612,0.037708875,0.0029705549,-0.00041036346,0.08154969,0.02887682,-0.0048068613,0.024317676,0.021813668,-0.044160947,-2.7685575e-33,0.0071643326,-0.077494614,-0.010133138,-0.054300733,-0.05072759,0.03823451,-0.012927305,0.006754439,-0.038797576,-0.13854273,0.050869577,-0.013630108,0.062685564,0.010977146,-0.0005287287,0.018530235,0.056442842,0.07458623,-0.034984853,-0.01833618,-0.07647339,-0.068102196,0.06632089,0.02959545,0.1178637,0.058353186,-0.037678797,0.07063754,-0.007522979,-0.0050992374,0.04343167,0.0016307762,-0.023680253,-0.043053757,-0.063202046,0.08750581,-0.04020872,-0.07708663,0.037290722,0.09808162,-0.075049624,0.018055651,0.0371444,0.15243843,0.02726182,0.039196104,-0.006623679,0.026565738,0.00096708926,-0.001380176,0.0009093588,-0.025777226,0.015427679,0.01063426,0.023657965,0.010512447,-0.010546103,0.061352484,0.04317629,-0.036188275,0.024612285,0.039884735,-0.057694133,-0.00794225,0.062106658,0.015879828,-0.025187073,0.02198669,0.03873221,0.0006122109,0.011018849,0.012925354,0.008926631,0.0051657083,-0.057943817,0.059370153,-0.0011674009,-0.012524226,-0.05367945,0.012469315,-0.04584507,0.031131605,-0.04001599,-0.018136665,-0.040515557,-0.048366006,-0.008217522,0.059186175,-0.032848906,0.015848331,-0.06419246,0.036806133,0.03744662,0.108649045,0.033517625,-3.5787625e-08,0.029778115,-0.076774195,0.018879741,-0.09218128,0.012496004,-0.01571967,0.020221602,0.056717455,0.028969316,-0.09930343,-0.04594924,0.013539684,-0.007999455,0.09203793,-0.034354936,0.02648246,0.040377095,0.052150756,0.036634598,0.05139211,-0.05208303,0.009225995,-0.075981624,-0.027199615,-0.09437476,-0.031635966,0.0564886,0.10819457,-0.038354576,0.009476762,0.088051535,-0.010202889,-0.056159522,-0.0383722,-0.020682292,0.09569944,-0.01751008,0.0038590124,-0.03996821,-0.031676814,-0.007169198,-0.043401442,-0.11381097,-0.00027971232,-0.010337975,-0.09651023,0.034083497,0.054418907,-0.0008708644,0.035830222,0.0040631173,-0.01762093,0.018697923,0.010600995,-0.004428274,-0.03073825,0.10117112,-0.04811678,0.022112304,-0.037078116,-0.04047695,-0.005556966,0.124959365,0.05988777 +3.4.22.33,"From the pineapple plant, Ananas comosus. Scarcely inhibited by chicken cystatin. Another cysteine endopeptidase, with similar action on small molecule substrates, pinguinain, is obtained from the related plant, Bromelia pinguin, but pinguinain differs from fruit bromelain in being inhibited by chicken cystatin [4].",384,1.0,0.0031913496,-0.038489252,-0.04068656,0.026686851,0.06510636,0.14182182,0.014906822,0.0054486026,0.05483768,0.026227219,0.060358275,-0.009736466,-0.03207882,-0.00010044307,-0.10052749,0.06677399,0.010077947,-0.018711528,0.003154951,-0.030607354,-0.03512592,0.037757725,-0.03413052,0.056432303,-0.019100204,-0.024252761,-0.032825187,-0.02463646,-0.103521354,-0.039254498,-0.0051467237,-0.050364036,0.04241226,0.09193555,-0.031280015,0.014218732,0.011802172,-0.023413034,0.084535606,-0.016460463,0.025092285,0.03940917,0.024764894,0.015870025,0.0107975425,0.03858461,-0.03921296,-0.0077634435,0.034715407,0.025926784,-0.09583986,-0.048532885,-0.0014179775,-0.02513531,0.036868576,0.079296365,-0.024161771,-0.035667818,0.023720363,0.033013396,0.0367332,-0.058115114,-0.055982545,-0.0585982,-0.02293765,-0.082706116,-0.030724606,-0.011606844,0.02577286,0.005166699,0.04097472,-0.0038540189,-0.06411779,0.036513858,-0.064857595,0.120981246,-0.09846575,-0.060964536,-0.08155619,-0.042023137,0.017577672,0.010405966,0.029511169,0.10358763,0.03324907,0.014356245,0.04910572,0.06310416,0.018253319,0.0723842,0.1034513,0.07362482,-0.04163474,-0.029135529,-0.010287083,-0.055279184,0.04882663,-0.067807496,-0.032684416,-0.007027697,0.041990075,-0.019058136,-0.043403175,-0.15158427,-0.04317295,0.0487465,0.017984092,-0.04586596,0.09082303,-0.045190312,-0.063911766,-0.0030813147,-0.04296024,-0.033315107,0.021797886,0.066382,0.040154714,0.021960884,-0.05357169,0.029756378,0.05612456,-0.0053235725,0.06338239,0.049359318,-0.062320825,0.07280007,-0.09228357,3.2353656e-33,0.044705052,0.027728861,0.026494907,0.033453397,0.06433988,-0.019669114,-0.039039817,0.020953653,0.023881039,-0.062884875,-0.0937201,-0.041692775,-0.0054038377,-0.034299523,0.012879253,0.019338205,-0.006241328,-0.058289956,0.065997474,-0.0348627,-0.020595497,0.012679099,-0.07500386,-0.017169503,-0.049142636,-0.025530666,0.043009434,0.01978079,0.07382666,-0.009848138,0.007961236,-0.009237927,-0.04328778,-0.02655027,0.059065964,-0.020404289,0.034720678,-0.06228017,-0.047313068,0.053163636,0.05370434,-0.05322127,0.05214146,-0.004123538,-0.005385746,-0.14219993,-0.049166583,0.039434552,-0.010458774,0.008394037,0.040981635,-0.06378642,0.08545582,-0.06888833,-0.002962866,-0.039009027,-0.041070238,0.04460726,0.027744561,0.079137586,-0.053579055,-0.030129602,-0.033716824,-0.051569678,-0.050820038,0.03531038,-0.083785735,-0.10655282,-0.10148229,0.027767733,0.041878056,-0.07429623,0.085187495,0.010246977,-0.012063,-0.044718247,-0.08893465,0.06450365,0.04019776,0.020624025,-0.009550429,0.0003643169,0.012824122,0.03312945,-0.040777024,-0.002661303,0.020838032,0.0037956245,0.019406581,0.040077887,0.040654104,-0.045019735,-0.009449727,0.030442912,-0.035816565,-2.6286981e-33,0.003196195,-0.06605895,-0.04119936,-0.018767165,-0.031986404,0.07419154,0.0012299839,-0.03839564,-0.021738596,-0.13611643,0.055201773,-0.061433304,0.07266464,-0.008615399,-0.0073464857,0.018235328,0.09371398,0.037758727,-0.028410641,-0.026604695,-0.09460313,-0.050660074,0.08813557,0.04177732,0.10923224,0.059968717,0.008118001,0.07660136,-0.02363586,0.04646061,0.03650331,0.01070548,-0.005170922,-0.03488056,-0.04854181,0.105514094,-0.02973261,-0.090123735,0.052250955,0.042898756,-0.033280533,-0.0009517296,0.03974444,0.1212708,0.05034838,0.0284653,-0.00860723,0.03226511,-0.041251052,0.0074600074,0.02337335,-0.039563816,-0.009006209,-0.010025743,0.04844381,0.019614695,-0.00090045005,0.027079064,0.05111854,-0.031753596,0.014560728,0.025570933,-0.005182798,-0.027780147,0.068820365,0.08971509,-0.0067811846,0.087408565,0.053269483,-0.028777707,0.059017267,0.0077831848,0.048847582,0.057983134,-0.031560216,0.05123287,0.04239247,0.026810221,-0.06913419,-0.00024168813,-0.03534929,0.027744668,-0.047980454,-0.047076084,-0.019641021,-0.028097322,-0.0016485755,0.068940945,-0.057437606,0.03950857,-0.058840435,-0.004653273,0.02589993,0.10298249,0.060279448,-3.069166e-08,0.06150831,-0.09161418,-0.0022669395,-0.095892735,-0.008942802,0.01639344,0.030684449,0.028562061,0.036699545,-0.10794252,-0.06857792,0.008225114,0.057274193,0.0993854,-0.03472082,-0.00070000713,0.06559747,0.04977122,0.0045886454,0.04150339,-0.07662935,0.05681032,-0.09046627,-0.0263173,-0.04997916,-0.073774226,0.038278673,0.041938607,-0.023560464,-0.030410908,0.007872923,-0.0049869674,-0.043676317,-0.015683124,0.002928761,0.09772229,0.010522725,-0.0029552444,0.00618439,-0.019058907,-0.06053887,0.0059496774,-0.1414928,-0.020921746,0.0080402745,-0.110126205,0.020094372,0.042534597,-0.0067143408,0.019332267,0.012548997,0.017689027,0.048364658,-0.030365763,-0.021148413,-0.018530844,0.12679362,-0.07959478,0.011472364,-0.029939579,-0.094775036,-0.03769797,0.09350107,0.037814826 +3.4.22.34,"Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13",384,1.0,0.0056198365,-0.011705834,-0.1017517,-0.09224506,0.0941095,0.037918847,-0.05852827,0.027454568,0.008346327,0.08482024,0.10167218,-0.012614314,0.03901063,-0.01028123,-0.021423748,-0.0029890388,-0.044996373,-0.045609977,0.014977533,-0.082587846,0.012291779,0.065654375,0.06842103,0.050145067,-0.029131096,-0.034485426,0.001881627,-0.03169402,0.014070757,-0.078314595,-0.044045817,0.028090073,0.02897156,-0.047259152,0.040917803,0.0059913346,-0.036619924,0.027743729,0.08613276,0.031981755,0.03467274,-0.041302647,0.010689347,-0.08364599,-0.023315892,-0.074390456,-0.06745594,0.10305842,0.051731296,-0.026015343,0.018448662,-0.045634784,-0.04214471,0.060074367,-0.023213105,-0.04185238,-0.07397458,0.017730372,0.01760235,0.008159792,0.045437496,-0.032828525,0.035567984,-0.0657771,-0.010142898,-0.057541873,-0.037200805,0.00393748,0.057702065,0.07110115,0.07974853,-0.034101438,0.0007390513,0.14644508,0.0045123487,0.113520674,-0.0031282718,-0.03523546,-0.06183294,-0.044657838,-0.03234803,-0.023772234,0.073769785,0.06681351,0.02636336,-0.01783156,0.01565988,0.08236496,0.08086025,-0.009280454,0.0661342,-0.088730365,0.07756955,0.014606323,-0.038428135,-0.03653867,-0.005818867,-0.03592937,-0.037077576,-0.027390638,0.057263214,-0.04167949,-0.03728739,-0.004333669,0.021802139,0.06670377,-0.03856857,0.04161546,0.041721705,-0.02544108,-0.0009398344,-0.031111948,0.018045668,-0.042228505,-0.067528315,-0.04088169,0.018342506,-0.04297821,0.054855693,-0.03782145,0.123712726,0.08396761,0.024504649,0.011883782,-0.0020800454,0.02584509,-0.093451045,3.3262324e-33,-0.036907393,0.0018955235,0.01737365,0.027483266,0.028363246,0.014262074,-0.07138588,-0.0066411705,-0.03575297,-0.050002355,-0.17203973,0.02186904,0.046123624,0.024808992,-0.051838443,0.016718127,-0.022313736,-0.0056240377,0.02232516,-0.022959491,-0.013863869,0.0004427448,-0.05691903,-0.045971777,0.06396116,-0.0052609975,-0.00821503,0.014361471,0.09525489,0.009286992,-0.019088812,0.001086421,-0.06776942,-0.00029891863,0.018208513,0.032946445,0.0097725345,-0.068108834,-0.0291759,-0.00094248255,0.050435763,0.044906434,0.01653973,-0.07821902,0.020719064,-0.051504504,-0.031988993,0.019466871,-0.018158877,0.003681676,0.052815292,-0.03202064,0.07019139,0.0372215,-0.054176506,-0.01925192,0.0166345,0.0326874,0.07920389,0.029481536,0.024575438,0.047609054,-0.01343718,0.045880727,-0.017844837,-0.007886959,-0.054104306,-0.043196414,-0.114535905,0.049365133,-0.080854364,0.010754682,0.047422573,-0.021612493,0.0337657,-0.11110222,-0.03944007,0.035023637,-0.095276125,0.09021316,0.070123196,-0.0959609,-0.063081436,0.030066043,-0.06262964,0.02881909,-0.044232074,0.035802063,0.00930468,0.004943158,0.022651354,-0.047491714,-0.02045756,0.10179397,-0.077629775,-3.3485867e-33,0.019962143,-0.015529594,0.13030979,-0.020335887,-0.030206129,0.06049866,0.0648782,-0.025881095,0.018837228,-0.09982732,0.106244676,-0.0017101552,0.0014750358,-0.033603434,0.053753365,-0.0013335043,-0.020395083,0.02433827,-0.006156407,-0.029517991,-0.12072138,-0.021582808,-0.067319214,0.027839419,-0.003574776,0.012297748,0.0068743303,0.060336355,-0.02489783,-0.042249184,-0.04257343,-0.027313318,-0.039071303,-0.017633688,-0.043177728,0.014273027,0.0010186462,-0.021076193,0.035245497,-0.03411792,-0.0052377777,0.08542314,0.036842186,0.08951035,0.039037433,0.058660503,-0.028279582,0.05948503,-0.011627299,-0.008477455,0.03256282,-0.04702136,0.003220813,-0.018819286,0.09815591,-0.07440958,-0.072125256,0.011445533,-0.008091599,0.052564394,0.0009815095,0.01778277,-0.06482029,0.06419818,0.10464292,0.025217706,-0.15239504,0.07345051,0.042158764,0.01047875,0.0750368,0.015414559,0.023980577,0.0019341619,0.0120959375,0.042489298,-0.06268256,-0.028825238,0.012367639,-0.05033464,0.0008063667,-0.05033552,0.04065679,0.05608147,-0.030797085,0.020686468,-0.0375394,0.09504038,0.032579087,0.055955958,0.020372266,-0.06674692,0.060976233,0.12931404,0.10874148,-2.7231666e-08,0.09116883,-0.048644893,-0.03629632,-0.07388742,-0.018428737,0.01754073,-0.014898283,0.017753309,0.051680658,-0.034749217,-0.06776801,0.039806545,0.019824415,0.03708037,-0.018274764,0.024359021,-0.012967845,0.06505311,0.004225018,0.03641844,-0.059013743,0.00012980832,-0.025116235,0.017269965,-0.020278392,-0.027051145,0.04329357,0.015366805,-0.014044834,-0.034593616,-0.06532285,0.0010913447,-0.030234236,-0.026623635,0.022974158,0.044900175,-0.063139275,0.0007665366,0.03720314,0.011635707,0.07958828,-0.007637093,-0.08896382,-0.09995686,-0.024382276,-0.038400255,-0.028777046,0.04889087,-0.038780246,-0.027605047,-0.045443848,0.067622475,0.018628951,-0.04379825,-0.061944727,-0.08341239,-0.034447428,-0.08412135,0.036208633,-0.10857921,0.05020482,-0.01788892,0.11198255,0.069484465 +3.4.22.35,"From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family)",384,1.0,-0.034636315,0.07587935,-0.08979704,-0.07813257,-0.021104436,-0.006818886,-0.015988922,0.06775965,-0.068539314,0.06150286,0.046871237,-0.111745,0.035439014,0.0069721583,-0.065923005,-0.013248737,0.029940017,-0.022555215,0.014594364,-0.046014104,-0.047393944,0.05171122,0.026857918,-0.023334397,-0.037511624,0.04317663,0.013345495,0.05565287,-0.0024395795,-0.10613853,-0.013325067,-0.024093721,0.055132903,-0.014799851,0.07172102,0.020052575,-0.0043422957,0.0021787672,0.13033116,-0.009840036,0.04592322,0.08749279,-0.0072883214,-0.088909216,-0.026923796,-0.026182104,-9.266882e-05,0.07353772,0.13471818,-0.049907837,-0.045081,-0.058622662,0.030357463,-0.000647447,0.0026315455,0.013467305,0.008914478,-0.06756528,-0.016052354,-0.0033143708,-0.01888409,-0.058816522,-0.0030980643,0.016446324,-0.044919137,-0.03647777,0.0385067,-0.028256811,-0.03568008,0.033192765,0.007208841,-0.010188383,0.0014173164,0.121140525,-0.07269072,0.03563412,0.0074187256,0.014713488,-0.08036771,-0.012301667,-0.040354718,0.024415433,0.013119949,-0.009557842,-0.03400083,0.0014461661,0.05056317,0.021063793,0.029650195,-0.0073040524,0.04561113,-0.027885944,0.056597352,-0.015119804,-0.118925676,0.0062248926,0.021985954,0.0072864867,0.008879403,-0.0089069195,0.03324325,-0.08071011,-0.0008489642,-0.07034139,-0.039944608,0.0369059,0.02594173,0.026283283,0.05166474,0.010402606,-0.09749989,-0.070372365,-0.023510547,-0.003625924,-0.0358669,-0.016583163,0.04769515,0.035178877,0.013067851,0.012254085,0.03046235,0.024762679,0.045810614,0.0073050866,-0.034909144,0.052286815,-0.04918805,1.5641313e-34,0.01019101,0.019431882,0.035810284,0.028760485,0.022739347,0.058165837,-0.04831118,0.04641801,0.009810858,-0.13140139,-0.12303965,-0.027823055,-0.026163219,-0.022000208,-0.07932819,0.08216186,-0.10846116,-0.048290532,0.009740823,0.06826462,-0.04769675,0.042342763,-0.05424093,-0.045395814,-0.016795225,0.09673494,0.01151972,-0.042696774,0.0057637813,0.00805305,0.03231013,-0.018120153,-0.105036564,0.025854956,0.0030760777,0.01864296,0.08213795,-0.03141128,-0.051036835,0.04240728,-0.035883937,-0.011569466,0.0018186538,-0.0167047,-0.011673258,-0.05063293,-0.012977946,0.00863894,0.06335212,-0.006790212,0.038118567,-0.0489882,0.07777696,-0.068941325,-0.027003415,0.008309052,0.061028767,0.049344417,0.06520257,0.08361907,0.12834722,0.016998641,0.012867359,0.04607103,0.0237135,-0.016693974,-0.009993482,0.053122133,-0.0041125827,-0.045948133,-0.025261186,-0.04050554,0.065213345,0.05221096,0.013044339,-0.05030344,0.007084259,-0.0066570668,-0.029061923,0.022191955,0.029664338,-0.017411912,-0.0061392314,-0.0039152773,-0.034473505,0.024562592,-0.046661492,0.05012114,-0.042941317,0.051869076,0.026230777,0.0006445856,-0.028091757,-0.013540754,-0.030321183,-2.6519408e-33,0.08729927,0.024793679,0.033082373,-0.032334566,-0.047980838,0.018409569,-0.014159653,0.12899557,0.012818876,0.019257737,0.023777982,-0.080222525,0.09763136,-0.07451652,-0.014982695,0.03863987,0.017292557,0.061952446,-0.053955626,-0.11983924,-0.09087899,-0.02549195,-0.04049862,-0.032218046,-0.0004062214,0.034646202,-0.0018768543,0.031000279,-0.097258925,0.0056856084,-0.040934455,0.025179356,-0.03837399,-0.05288653,-0.02455436,0.021636473,-0.07925422,-0.09620558,0.038579386,-0.036200114,-0.033878695,0.08452558,0.086992286,0.106515735,0.00862668,0.0067921216,-0.056276362,-0.030912276,-0.012425134,0.040615626,0.031837367,0.0032852564,0.033774365,-0.036203656,0.03576978,-0.038625583,0.02145563,0.05894077,0.0026307171,0.07377286,0.05905085,0.021424357,-0.076067105,0.1025398,0.039750177,0.06918482,-0.1477444,0.011494994,0.04110698,0.028534127,-0.010889303,-0.13990724,0.006313814,0.006515684,0.00408296,0.13733883,-0.055466224,-0.04440965,0.012309025,-0.029468257,-0.01867595,-0.08335702,0.016012274,0.043160927,-0.0434063,-0.08101839,-0.049746335,-0.027676223,-0.018523593,0.042096924,0.025422938,0.01946725,0.006358144,0.1017611,0.033620212,-2.451584e-08,0.12424267,-0.10379869,0.026415115,-0.023107316,0.008723791,0.008667002,-0.040311854,-0.022324342,0.09721563,-0.0016969672,-0.04375251,-0.004492774,-0.0140597075,0.05943456,0.011809449,0.050598305,-0.009094717,0.00700641,0.006313114,0.034960464,-0.10640439,-0.014664929,-0.058417972,0.03084369,0.013994642,-0.0115371905,0.0052832034,0.077706926,0.05609242,-0.030640416,-0.024800276,-0.023287699,-0.06446043,-0.094272725,-0.017754773,0.06183801,-0.06377192,-0.038143635,0.03351199,-0.06662606,0.07799369,-0.0037381346,-0.055950634,-0.06161781,0.011724997,0.016657623,-0.004009204,0.07979075,-0.05734029,-0.074429415,-0.08096935,0.027429676,0.037878904,-0.037014674,-0.111370206,-0.028767481,0.009647165,-0.015556479,0.044506077,-0.0151087465,0.01956438,0.09290074,0.10299048,0.10790029 +3.4.22.36," From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6,7]. Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor [6]. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mice, whereas caspase-4 enhances its activation in humans [7]. Belongs in peptidase family C14.",384,0.99999994,-0.06773412,-0.04282846,-0.003963767,0.009124006,0.03979179,0.00020877524,-0.0291101,0.107615806,0.048336897,0.028043348,-0.03527549,-0.01109202,0.024086626,0.06970742,0.010118508,0.0059942985,0.018462563,0.049865656,-0.070606805,-0.081879534,-0.010855162,-0.070783235,0.022137081,-0.00078216783,-0.03503867,-0.028550053,0.0069159465,-0.03478729,-0.030730614,0.0018298057,0.024617847,-0.05766468,0.04401714,-0.017903244,-0.038641844,-0.014522935,-0.03280883,-0.017110493,0.051038116,-0.03912381,0.04803642,0.009700108,0.06340227,-0.0725326,0.09709278,-0.03505861,0.008228729,0.048933513,0.030224483,0.07194371,0.0073855654,0.044363476,0.027680662,0.07142688,-0.038270526,0.020844853,-0.068393275,-0.042029552,0.07792413,0.0065686097,-0.059217587,-0.042238735,0.07858626,0.042194117,-0.028128996,-0.06354951,0.013040711,0.013998804,-0.10238794,-0.02095106,-0.0034012522,-0.0028564392,-0.055232566,0.06886254,0.04464725,0.10107675,0.028526152,-0.078958265,0.0512062,-0.06740754,0.14513898,0.047397286,0.088497095,0.06825482,0.019232865,-0.016059259,0.044252913,0.022984765,-0.012661648,0.059364628,0.012058305,-0.060604587,0.00045833105,0.040983036,-0.013192627,0.05628488,-0.03448012,0.03635668,-0.049420513,0.039615914,-0.06249577,0.0127908075,-0.032325223,-0.06047266,0.00065228215,0.04345314,0.0021846814,0.062328115,0.053411882,0.050826646,0.024214292,-0.06817781,-0.03999262,-0.03361057,0.04531365,0.1315114,0.024364132,0.022458196,0.09657274,-0.044575714,-0.004216466,-0.03756193,-0.011764245,0.0019931414,-0.03495002,0.03583917,0.012777197,4.305779e-34,0.015100594,-0.0076681953,0.001170783,0.039081465,0.08047124,-0.05054628,0.010303075,-0.0034140276,-0.0818008,-0.009322406,0.005772073,-0.019565886,0.0143878,0.015019647,-0.017932877,0.024760632,-0.028607387,-0.034564782,-0.04684077,-0.068134926,-0.02645737,-0.052062135,-0.027074287,0.021035757,0.012511233,-0.0010625197,-0.003008047,0.0891819,0.013729457,0.0011389279,-0.09665724,0.018587708,-0.05372288,0.004856338,0.008179695,-0.023285542,-0.010997131,-0.026591845,-0.035039276,0.02641045,-0.053903654,0.013293099,-0.102669716,-0.071125045,0.07628257,-0.1890742,-0.00025519083,0.01789791,-0.05964098,0.07398597,0.056821994,0.020034308,0.06180206,0.03351341,0.0065932972,0.0019291635,-0.038627032,0.009698291,0.04781717,0.0027603281,0.07250902,-0.066650525,-0.056729358,0.13356665,-0.025291666,0.062106833,-0.019860748,-0.07890971,-0.052068394,0.01847215,0.039952587,-0.011129619,-0.0560714,-0.0017319975,0.016536891,-0.0021785884,0.072180554,0.036911707,-0.09030928,-0.00052827626,-0.069550335,-0.004421384,-0.04205079,0.087836646,-0.04074454,-0.0011317059,0.006530194,-0.04931272,0.022228902,-0.1253916,0.10791217,0.0011506227,-0.05624917,0.1055753,-0.011816498,-2.3322561e-33,0.012481787,-0.044922974,0.02518161,-0.1358494,-0.10135468,0.028086068,0.066786215,-0.07229439,0.041952644,-0.05965653,0.0033118636,-0.045225784,-0.01235012,-0.017787676,0.03622123,-0.031552248,-0.0031644956,0.044929218,-0.057394546,0.015416305,0.10788381,0.1047339,-0.027612472,0.15833524,0.047520414,-0.029254122,-0.008388119,-0.007206058,0.024249762,0.09890706,-0.05260392,0.017045755,0.03513699,-0.031453185,-0.016959252,-0.014407273,0.03395646,-0.034664467,-0.023116285,-0.012879341,-0.052505165,0.009836927,-0.01687441,0.06353712,0.02597441,0.090295576,0.016421005,0.042202897,0.039933097,0.035153568,-0.05271622,-0.021634758,0.035783004,0.015952604,0.009950946,-0.014942404,0.02560324,-0.014828185,-0.024582589,-0.04190672,-0.014212825,0.038054124,-0.013758862,-0.018109065,0.048488136,0.035913173,-0.046421938,-0.071030214,0.0030939586,0.017473843,0.09298235,0.0063639027,-0.09168232,-0.028834306,-0.0049108053,0.02414921,0.012876869,-0.03244403,-0.024729565,-0.010708743,-0.032490015,0.014315416,0.010185125,-0.0708992,-0.041926924,0.005240724,-0.0043654228,0.07181459,-0.045685224,0.11651877,-0.040086117,-0.023996105,-0.056510616,0.03975129,-0.09770087,-5.1047646e-08,0.08080146,0.048098445,-0.05557732,-0.07132611,-0.11878192,-0.008433311,-0.04970236,-0.0019877134,0.057998303,-0.051473167,0.00010988799,0.10994298,4.7878988e-05,-0.009069948,0.0259123,0.03872758,0.020413728,-0.0024369587,-0.028008427,0.009792902,0.023447612,-0.047286708,0.025771098,-0.05961574,-0.00070837344,-0.09964222,-0.024679795,0.036540404,0.019808304,-0.057177115,-0.07260284,-0.01355277,0.056285013,-0.08393604,0.025088917,0.06431015,0.006919013,-0.070427276,-0.031629816,0.04000334,0.07214357,-0.041499563,-0.007885474,-0.09838691,0.021409145,0.041961472,0.003033707,-0.0045632496,-0.0102485465,-0.027162343,-0.1546894,-0.044622805,-0.015474448,0.009429733,-0.041448012,0.0553614,-0.0683215,-0.03061549,0.109863915,-0.0637351,0.048469562,0.08099988,0.041237883,-0.041730385 +3.4.22.37,"A secreted endopeptidase from the bacterium Porphyromonas gingivalis. Strongly activated by glycine [1], and stabilized by Ca2+. Precursor molecule contains a hemagglutinin domain [2,3]. Misleadingly described in some literature as ""trypsin-like"", being a cysteine peptidase, type example of peptidase family C25.",384,1.0,-0.047478803,-0.033021167,-0.10232673,-0.041162454,0.02533525,0.06048708,0.032862976,0.07093254,0.09879613,0.09632874,0.045372225,-0.052734673,-0.066239625,0.12425217,-0.061067507,-0.008161765,-0.02813097,-0.026964026,-0.014447141,-0.02517306,0.044588517,0.08442299,-0.016647216,-0.007598742,-0.026921486,-0.003334096,-0.022925619,-0.05340812,0.0037255813,0.03725034,-0.006637945,-0.07463038,-0.037241094,-0.08003582,0.05942454,0.06561748,-0.023931457,0.007781426,0.07601463,0.00048534005,0.0024514997,0.013565761,-0.05310406,0.051315,-0.010889647,0.043044027,0.03308324,0.13423058,0.034791503,-0.023448884,-0.0075969175,-0.06269617,-0.009047104,-0.05718992,0.04245752,0.03286493,-0.03274195,0.0062905666,0.07045238,0.02818068,0.03406135,-0.0440436,0.027823223,-0.027850231,0.007992367,-0.08829567,0.011583297,0.0015345084,0.02838091,-0.011879486,-0.018382525,-0.051918443,-0.0773511,0.04640896,0.020911215,0.09262594,-0.069326535,-0.03458498,-0.046906643,-0.052310336,0.07488671,-0.007327481,0.07316492,0.15192036,-0.0036279678,-0.022637995,0.025046237,0.06044994,0.002889399,-0.052663837,-0.006636287,-0.084911056,0.024436483,-0.038204573,-0.004481846,-0.013677807,-0.014487482,-0.046877015,-0.0234041,-0.031688806,-0.039230846,-0.03685843,0.010008488,-0.12826955,0.019240892,0.034395956,-0.061704118,0.06684112,0.15310486,-0.036450844,0.00030731666,0.027730105,0.031039163,-0.06609649,0.056214873,0.058446832,0.003017223,-0.012286658,-0.009937736,0.02461627,0.034554508,-0.005371417,-0.011131831,0.006228196,-0.062436137,0.036132023,-0.03662259,2.9973868e-33,0.088635616,-0.004823425,0.04336427,0.05470159,-0.015947634,0.045442883,-0.012299823,-0.034722567,-0.0030477913,0.020402601,-0.09610305,-0.100665405,-0.052363303,0.050636664,-0.021474011,0.031094529,-0.12926275,-0.028585576,0.020986173,0.038927387,0.025282227,0.13394351,-0.013652735,-0.06170122,0.062331606,0.07705093,-0.021928273,-0.048111886,0.082037576,-0.017714515,-0.008464569,-0.04056165,-0.094993316,-0.010392419,0.07058043,-0.032558452,0.055198755,-0.0729444,-0.005975518,-0.050655924,-0.005711946,0.0053389315,-0.052814737,-0.018110126,0.08485113,-0.058523417,-0.082490884,0.027261771,0.015521139,0.06631677,0.04965826,-0.032498118,0.073859595,0.020871425,-0.07998449,-0.005270839,0.010561789,0.03778114,0.05478878,0.019459624,0.010600812,0.024259983,-0.056592878,-0.051009405,-0.028177014,0.01986129,0.0026481107,-0.05041575,0.0074085672,0.038945593,-0.03214043,0.004571224,0.0014798538,0.010248128,-0.0071224477,-0.057419352,-0.008483477,0.10436124,0.043917265,-0.024277316,0.033886325,-0.028783852,-0.024117893,0.035471015,-0.06300615,-0.0055100694,0.034070365,-0.05287785,-0.07990761,0.032080464,-0.014090411,0.001137585,-0.013149088,0.06918454,-0.089118235,-3.2128656e-33,0.077505,-0.10091685,0.022036346,-0.022040822,-0.020828778,0.07652784,-0.04845975,-0.049121052,-0.04318823,-0.047858194,0.107429,-0.033643518,0.052643977,0.031243399,-0.028863784,-0.013322954,0.043372843,0.05551583,-0.06741852,-0.040582437,-0.055747565,-0.058728386,-0.011053987,0.01966545,0.13743345,0.062070776,-0.038844056,0.000504297,-0.03637098,0.040395916,-0.00482437,0.04763933,-0.05776687,-0.0358616,-0.027421882,0.03445953,-0.07156188,-0.020555785,0.003957107,-0.049874157,-0.00026907737,0.009885511,0.076465115,0.12311834,0.018276082,0.0718784,-0.079779014,0.02234302,-0.04240089,-0.0046928297,-0.005912072,-0.040366367,-0.024704255,0.014325612,0.009801809,-0.03437645,0.04388259,0.0007279072,-0.003795729,0.015355136,0.0025651383,-0.015937047,0.018738315,0.03474686,0.08090655,0.0406068,-0.077699125,0.01444094,0.054361667,-0.029625647,0.05610482,-0.067700796,0.07944778,0.032357477,-0.0074660787,0.02264511,-0.023502992,-0.07148862,0.047967475,-0.039605852,-0.038930867,-0.01045711,0.011051969,0.012360026,0.051605653,-0.067755684,-0.016065473,0.04655208,0.0327491,0.08806619,-0.059950218,0.047601692,0.02928714,0.029470192,0.09462708,-3.9367116e-08,0.040485173,-0.0025258285,0.036329925,-0.102517635,-0.066785686,-0.012062487,-0.019153183,0.017062997,0.013982535,-0.06082532,0.04274966,0.004514569,0.001798697,-0.0075970525,-0.002173323,0.057998933,0.018553345,0.0026410206,0.016588172,-0.009734324,-0.10513551,0.025799828,-0.09523605,-0.018763375,-0.023386933,-0.071728416,0.014099449,0.060592473,0.032717153,-0.011544039,0.035717543,0.012908266,-0.050862655,0.0004873927,-0.047998812,0.12641808,-0.053670257,0.0057656397,-0.057177838,-0.05161955,-0.040894743,-0.0076717935,-0.07532698,-0.04923697,-0.039118096,-0.034275014,0.11380078,0.04103226,-0.038274467,0.0054340987,0.012788915,-0.0040051537,0.008310043,-0.038792383,-0.1340092,0.0059759337,-0.018029077,-0.018190356,0.023226794,-0.09749059,-0.03569678,0.0122190155,0.15936518,0.07760406 +3.4.22.38,"Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family)",384,1.0,-0.11301742,-0.010637118,-0.042892873,0.002242189,0.0021887165,0.02089406,-0.045436338,0.043883372,0.056254607,0.061926816,-0.015211602,0.040737964,-0.0068359855,0.015416032,-0.08000413,-0.076051734,-0.11750627,0.04975464,-0.044766624,-0.022366855,0.0047986927,-0.020178135,0.038215317,0.03796201,-0.040815257,-0.03574617,-0.007121664,0.016506488,0.02621812,0.010909827,-0.05697182,0.00071297365,0.09529784,-0.047286816,0.06720024,0.06526944,0.025527935,-0.12984875,0.015628982,0.01105154,0.102494,0.025986345,-0.0050483667,-0.04466642,0.08221357,-0.0033756269,-0.032762595,0.03435786,0.054531045,0.02596727,-0.008455465,-0.045901902,-0.023666633,0.019715676,-0.014635973,0.07739344,-0.050816562,-0.07511205,0.084321156,0.016826894,0.038491655,0.0028998386,-0.012548139,0.05115301,-0.016872715,-0.070309326,0.057151496,-0.034652535,-0.1367586,0.016992142,0.061860327,-0.012095705,0.0774199,0.08727412,-0.013377047,0.07711921,-0.040428713,-0.06601061,-0.12980038,0.012813511,0.013994265,0.051413447,0.038835406,0.03748461,-0.0468159,-0.0064322124,0.024583349,-0.010428629,-0.037080396,-0.032061517,-0.0007305811,-0.0763878,0.01243404,0.023319216,-0.056308,0.019066429,0.031793807,-0.014597793,-0.005728045,-0.0042952485,-0.016529424,0.03369017,0.021304408,-0.056992583,-0.0060092816,0.062918015,-0.10964965,0.077711344,0.059846383,0.059853904,-0.024191149,-0.023663279,-0.02437782,0.03386089,-0.06411684,0.010917291,0.016425496,-0.0012475721,0.024353739,-0.0392855,-0.0075341407,0.008393873,-0.04004472,-0.009448383,-0.0214505,-0.09631382,-0.092829265,-2.0160966e-34,-0.026776949,-0.06667701,0.040959265,-0.024214486,0.03406281,-0.02344377,-0.090988785,-0.051710024,-0.015082337,-0.08544399,-0.061199278,0.017199645,0.0057638176,-0.050319184,-0.04804579,0.07545065,-0.05639678,0.007963478,-0.011775661,0.035852898,0.029932339,0.11696265,-0.016263986,0.0073130513,0.079633184,-0.010459714,-0.067228556,-0.07329653,0.033798482,-0.017395739,-0.028351827,0.008781268,-0.048996642,-0.045846965,-0.016702307,-0.043174922,0.07181887,-0.13129117,-0.050241865,0.03859795,0.06703548,-0.049918603,0.029769711,-0.06668806,0.04323504,-0.059945088,0.00876018,0.04350798,-0.056749254,0.008964737,0.024534943,0.00955634,0.044363193,0.0010142305,-0.11152935,-0.005066066,0.021129187,-0.08404559,0.03344056,0.07862114,0.035517067,-0.089940965,0.05170736,0.057531744,0.02345691,-0.02074312,-0.08996515,-0.0022094827,-0.028532952,0.10956232,-0.009137712,-0.0014374731,0.032766096,0.040290274,0.014526261,-0.020942725,0.056264766,0.12142245,-0.07929651,0.03372012,0.07378527,0.013994437,0.030713512,0.057260416,-0.045650635,-0.019812135,0.076437674,-0.029851248,-0.014638467,0.01439545,0.017628543,-0.052862115,-0.062095907,-0.056331947,-0.07130335,-1.7197499e-33,0.09955405,0.0021262874,0.07586944,-0.085048266,-0.076762594,0.049771838,-0.029210132,0.015465061,0.020684728,-0.10218105,0.0146942455,-0.060498774,0.018936723,-0.08295549,0.011992877,0.043579195,0.025850056,0.034759827,-0.099943645,0.010745522,-0.027026506,0.017195363,0.0023848086,0.011066687,0.076207295,-0.030402983,-0.010740901,0.05056544,-0.050390095,0.0336246,-0.1003891,0.003496338,-0.06748809,-0.05857355,0.02052009,0.06253015,-0.036400262,-0.02939641,-0.0012316912,-0.022696422,0.030250592,0.047862392,0.0367068,0.06848892,-0.025943238,0.054787565,0.0036532714,0.06087563,-0.00067493005,-0.017209845,0.020105503,-0.026610741,0.06961537,0.034507055,0.08132946,-0.034374725,0.037298728,-0.038307976,-0.018262722,0.021448059,0.067291394,0.029210797,-0.015614274,0.06466057,0.030140428,0.020557305,-0.09083442,-0.035257913,-0.019282417,0.047275096,0.035001315,-0.01689099,0.09922554,0.053508915,-0.02304793,0.07633064,-0.0497519,-0.09048757,-0.050566155,0.0062978263,-0.036922973,-0.038285445,-0.029478353,0.014725603,-0.016455838,-0.03953149,0.019254578,0.08137666,0.0076833335,0.053912062,0.02333299,-0.029460082,0.103756495,0.058781475,0.038826,-2.6948191e-08,0.03670639,0.016737636,-0.015034009,-0.060134478,-0.020208605,-0.012763838,0.0010771751,-0.030878449,0.02291737,0.019530362,-0.01884129,0.021722877,0.028380245,0.018826192,-0.018646227,0.13795769,-0.031369787,-0.00022644777,0.059985433,0.040038355,-0.086318515,-0.042817514,0.0064463597,0.036054075,0.024247779,0.005852544,0.0030756455,0.07305572,-0.04609273,0.026898826,0.051474184,-0.018465573,0.006621167,-0.097244754,0.07098038,0.06729954,0.02463446,-0.03730218,-0.021347588,-0.04895736,0.049831133,0.008848155,-0.06005567,-0.014298896,-0.061541773,-0.027060317,-0.03240845,0.1232989,-0.00013158644,-0.033431135,0.014836297,0.014982785,-0.08843365,-0.10631187,-0.09521497,-0.0077197733,0.041408997,-0.004334086,0.06209528,0.01823366,0.026850263,0.043674856,0.15650204,0.054032452 +3.4.22.39,"A cysteine endopeptidase from adenoviruses, the type example of peptidase family C5, with a protein fold unlike that known for any other peptidase [2]. Activity is greatly stimulated by the binding to the enzyme of an 11-residue peptide from the adenovirus capsid protein pre-VI at a site separate from the active site [1]",384,1.0,-0.029867373,-0.07266158,-0.03075654,-0.025515722,0.0902311,0.07438163,0.013219133,0.06847211,0.067072205,0.10258271,0.015726833,0.0115597285,-0.039088514,0.09197579,-0.02133608,0.03676076,-0.08859836,-0.039238367,-0.032848448,-0.076318555,0.024406059,0.048967946,0.011783646,0.014973328,-0.06412879,0.016581554,0.014070471,-0.00986441,-0.015938332,-0.003979402,0.007966257,-0.14301625,0.013826544,0.018944884,0.05761518,0.12474077,-0.06919174,0.0042100544,-0.0042446484,-0.011568726,0.032053545,0.034521192,-0.019961879,0.05912247,0.029169923,0.008613308,-0.028316837,0.07771676,0.07426339,0.019182319,0.04530846,-0.092261754,-0.011296824,-0.061927963,-0.014225872,0.06858656,-0.08597389,-0.031839002,0.038126558,0.03657624,0.03563543,-0.010747466,-0.007841876,-0.031445265,0.0228665,-0.08820457,0.035481714,-0.0057727653,-0.006485539,-0.038763206,-0.05045392,-0.04887073,-0.08614624,0.042830486,-0.007500992,0.043940492,-0.054268114,-0.077878125,-0.08301234,0.00076310174,0.0032448191,-0.0002891439,0.1076637,0.09532006,0.009986546,-0.024365952,0.00025349512,0.013410553,0.039776478,0.0004880151,0.006126945,-0.071405746,0.023013124,0.0010430942,-0.034373537,-0.06091555,0.05217005,-0.06832,0.00025626196,0.007955478,-0.0117259,-0.027465843,-0.02221241,-0.05726108,-0.001805693,0.033799183,-0.04961655,0.05261761,0.006691358,-0.039867733,-0.014032545,0.026785845,0.009355163,-0.114792794,0.07636539,0.08141326,-0.035588473,-0.012480128,-0.007106103,0.011670817,0.0014452988,-0.0002847883,0.03647479,0.082383275,-0.07156996,0.048133742,-0.0721068,1.7537584e-33,-0.02604572,-0.028090853,0.053390212,0.06932505,-0.003141193,0.024530707,-0.014287623,0.064209834,-0.015656024,0.022151733,-0.029066658,-0.017167697,0.07210497,-0.017403893,-0.02304215,-0.0029334843,-0.06501537,0.048415978,0.00502123,0.013747311,-0.004963454,0.064880766,0.052444536,-0.01684391,0.05174401,0.054101188,-0.059870988,-0.016540108,0.11133884,-0.020350432,-0.08699323,0.03651945,-0.11359821,-0.022200663,0.01234301,-0.0072541097,0.07295687,-0.06324574,0.008681202,0.014095909,0.014423081,-0.013926931,-0.0051875883,-0.06716079,0.05187216,-0.11116717,-0.017918194,0.07685259,-0.08158651,-0.00929433,0.034301396,-0.022231625,0.086328395,-0.0049763075,-0.06363943,0.020405743,0.011197982,0.007394902,0.0491328,0.045175664,0.06464132,0.043023825,-0.05386235,-0.06833736,-0.04939257,0.028476682,0.0020674262,-0.052964255,0.0046433955,0.16653498,-0.0020496338,0.099180296,0.030665707,0.03753214,0.046987362,-0.027482938,-0.11577688,0.05429577,0.040284615,0.048718337,-0.003014971,0.01751191,0.032106776,-0.020366067,0.0045732907,-0.028851297,-0.015751785,-0.078535035,-0.093543366,0.05966629,0.020694429,-0.04047383,0.03200588,0.058158867,-0.05375578,-2.6760024e-33,0.038275804,-0.1091028,-0.076288015,-0.0406113,-0.046178587,0.03612554,-0.009980067,-0.027134985,-0.029449359,-0.06865734,0.07168687,-0.022925526,0.023550617,0.012188633,-0.010400797,-0.020796182,-0.023718579,0.09046216,-0.007756074,-0.011744327,-0.04591118,-0.06051136,0.053237468,-9.777216e-05,0.10506718,0.00049256976,-0.057578273,0.06148372,0.014765991,0.015734296,-0.055907622,0.014159274,-0.001401677,-0.0046217944,-0.04424807,0.10470079,-0.10525901,-0.019153178,0.057355326,0.029185737,0.003750616,0.042132374,0.06352421,0.13265474,-0.04047253,0.061892256,-0.045518473,0.094266556,0.012929211,-0.07891218,-0.0049149483,-0.106271304,-0.0033384261,0.01538456,-0.023316808,0.061744656,0.017633872,0.04229252,0.021540439,-0.014317711,0.015508965,-0.041455127,-0.029379474,0.0015448559,0.089029565,-0.012628337,-0.06182692,0.010905966,0.0292255,-0.03030852,0.029901689,-0.08481863,0.054241855,0.033238508,0.005140583,0.061182536,0.0434917,-0.025308942,0.03814247,-0.05433887,-0.06445048,0.015738474,0.008767689,-0.041413043,0.053863697,0.004232289,-0.006333238,0.04542127,0.010986185,0.10249975,-0.029486507,0.016146926,0.08279416,0.0716005,0.015210009,-3.532795e-08,0.09407557,-0.025415335,0.037981186,-0.11035708,-0.020365627,0.04113271,-0.004623566,-0.016185978,-0.013573885,-0.038241092,0.023568511,0.039953426,0.0003475685,0.08930336,-0.034577902,0.07699467,-0.009507607,0.06404099,0.013354533,-0.042204835,-0.14372545,0.018527256,-0.097212866,-0.0420258,-0.031770807,-0.067822605,-0.013735831,0.0679344,-0.012682742,-0.032339953,-0.01612357,-0.020270258,-0.06888503,-0.03732504,0.019193657,0.11707322,-0.048080895,4.4090968e-05,-0.06117427,-0.01896163,0.018348394,-0.05211951,-0.0888904,-0.02822226,0.0031563046,-0.0051015834,0.013932629,0.008921023,-0.02270366,0.008530266,0.014241055,-0.023944568,-0.013576936,-0.036007725,-0.06652106,-0.014701823,-0.015998153,-0.07776982,0.02503179,-0.10439308,-0.04978189,0.017198093,0.125047,0.01412114 +3.4.22.40,"The molecule is a homohexamer in which the monomers have a papain-like tertiary structure (in peptidase family C1). The active sites are on the walls of a central channel through the molecule, and access of substrate molecules to them is obstructed by this and by the C-terminus of each polypeptide chain [3]. Bleomycin can scarcely be the natural substrate, and there are reports of limited endopeptidase activity. Known from bacteria as well as eukaryotic organisms. Hydrolase H from chicken muscle has many similarities to bleomycin hydrolase, but hydrolyses Ph-CO-Arg-2-naphthylamine as well as aminopeptidase substrates [2].",384,0.9999999,-0.014017402,-0.10719847,-0.07978685,-0.09427144,0.0027868985,0.02768666,0.012688888,0.0587189,0.06990537,0.013543062,-0.0005589663,-0.03469078,0.008286446,0.1225842,-0.038730625,0.024634978,-0.12630463,-0.06880339,0.036453366,-0.056792524,0.06990586,0.075552806,0.004456208,0.05325515,-0.026526975,-0.036457427,0.052979983,0.02331013,-0.05840589,-0.05338077,0.014886302,-0.07215499,0.014965209,0.005380003,0.08926738,0.06201685,-0.055911265,-0.052097812,0.06316563,-0.012572216,0.027032472,-0.038893845,-0.009268955,0.008028777,0.0024721043,0.052104227,-0.014999694,-0.028566917,0.020047482,0.0038092914,-0.03996647,-0.06717352,0.00059133704,0.030942794,0.054069057,0.062112547,-0.0686985,0.01189858,0.027043391,-0.008332802,0.044138484,-0.035785597,0.010129174,-0.016352933,-0.051327553,-0.036076106,0.010262219,-0.05518761,0.016999338,-0.030723728,-0.040720176,-0.08665302,-0.005677831,0.025161797,0.050799426,-0.037642054,-0.09088597,-0.00015490009,-0.0753764,-0.056983225,0.022424435,-0.044892427,0.022721255,0.16123298,0.009509836,-0.022690974,0.06255203,-0.0076853703,0.006550154,-0.00962741,-0.013827853,-0.032985006,-0.07088836,-0.04006227,-0.045187913,-0.053046245,0.018847337,-0.042949595,0.03813433,-0.041066073,-0.036472823,-0.026376681,-0.008348907,-0.037201475,-0.039348967,0.048122738,0.035561968,0.11871171,0.12260049,-0.05598692,-0.033947084,0.046917334,-0.008904394,-0.035281043,0.024538502,0.016065152,0.059015904,-0.04354277,-0.025961123,-0.036838405,0.042575456,0.00017614181,0.099906534,0.023409171,-0.056042317,0.082867265,-0.14378649,1.5530427e-33,0.06936927,0.01176618,0.018825123,-0.027103033,-0.03043798,0.014796406,-0.05114951,0.030430222,0.0075597055,-0.07039093,-0.040049106,-0.030075423,-0.027761584,0.075906426,0.044325057,-0.02902414,-0.043946154,0.036763754,-0.0008409013,0.027788002,0.014163673,0.0741125,-0.043681994,-0.0332808,0.07453708,-0.009071334,-0.012764176,-0.017028408,0.0488926,-0.02458303,-0.0032900656,-0.051423293,-0.085221946,0.023541672,0.045957115,0.026158359,0.010706362,-0.018970821,0.038604006,0.036267865,0.016263975,-0.06275912,0.034461625,-0.09695526,0.065051846,-0.06983436,-0.02790276,0.037492227,-0.019775277,0.018184647,0.049532123,-0.06765972,0.10393072,-0.07069649,-0.02179363,0.036458407,-0.002327273,0.058807503,0.06430879,0.09240957,0.046646826,0.036434762,-0.04798233,-0.038933747,0.01946186,0.028566914,-0.08072895,-0.027788851,-0.021130575,0.073970534,-0.031143295,-0.008869943,0.11248459,-0.029304534,0.029753698,0.0027888007,-0.09711567,0.061852727,0.048230287,0.043101538,0.05438739,0.024781665,0.043156896,0.009375157,-0.039609436,0.027641509,0.05904916,-0.11805758,-0.021204654,0.08273006,-0.02016598,-0.073872276,-0.024126343,0.020049132,-0.03970718,-2.8715742e-33,0.10257018,-0.05090513,-0.0015233383,-0.043056022,-0.02592045,0.05021893,0.07686034,0.024689423,0.014731114,-0.074677736,0.086553656,0.0148742935,-0.06525031,-0.067212984,-0.00025390775,-0.008359031,-0.011570405,0.07462141,-0.002552163,-0.014516679,-0.057215195,0.052154306,0.032764148,0.006274966,0.0916953,0.02307291,-0.021393536,0.08175383,0.013863539,0.017223245,-0.027764859,-0.01695838,-0.022460908,-0.067081824,-0.016383981,0.10496264,-0.13135377,-0.0242969,0.03389261,-0.051140577,0.021960251,-0.021728631,0.022818232,0.008607507,0.04863024,0.044073008,-0.07523816,0.034905795,-0.015679443,-0.020254578,-0.041161776,-0.021488609,0.022124201,-0.06432384,0.023114782,0.016837837,0.03085754,0.025775079,0.03701498,-0.056363363,-0.035512842,0.009056347,0.043933935,0.062098667,0.0126943905,0.039330617,-0.0799285,0.01353573,0.071132794,-0.020905107,0.006566731,-0.011000511,0.035928432,0.0529623,-0.003041757,0.05772046,-0.07697185,-0.088784076,-0.007690501,0.026576415,-0.004369948,0.026444163,-0.043038424,-0.040170062,0.034969192,-0.04978694,0.014608293,-0.0031240322,-0.008808694,-0.0065645184,0.040096287,-0.03319285,0.008413578,0.059592284,0.0506073,-4.346941e-08,0.06121581,-0.02522561,0.047229193,-0.07203885,0.01878877,-0.05872367,0.0119543495,-0.04164113,0.067970045,-0.08067291,-0.05403923,0.0050707026,0.0046587917,0.049294874,-0.052989777,0.058351357,-0.052922122,-0.032911133,-0.007675168,0.0131640015,-0.11415818,-0.032005336,-0.13603944,0.06740591,0.02769548,-0.073367804,-0.0022948582,0.06238353,0.03894566,-0.019277964,0.030089969,0.016522484,-0.024145368,0.011889207,0.032706678,0.03620964,-0.09462815,0.043650042,-0.057469614,0.033252645,0.06416614,-0.07644483,-0.030130563,0.001448648,0.018849902,0.03149249,-0.07669316,0.021096803,-0.039348792,0.0057975487,0.076356746,-0.013269039,0.032789707,-0.04079049,-0.10087211,0.016531283,0.029335901,-0.082241155,0.038844656,-0.08176587,-0.0079934085,0.06408765,0.20967835,0.03660707 +3.4.22.41,"Cathepsin F is a lysosomal cysteine endopeptidase of family C1 (papain family), most active at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3",384,1.0,0.048704308,-0.00089807657,-0.070508696,-0.038697634,0.09811189,0.060837615,-0.060388014,0.107614025,0.005346917,0.01545927,0.039321534,-0.046269216,-0.09756389,0.04203181,-0.11502733,-0.037435737,-0.121638164,-0.020079812,-0.016364057,-0.016476164,-0.008842246,0.022319747,0.013018778,0.023344439,-0.045052957,0.004706831,-0.004528339,-0.028343285,-0.0664024,-0.011167909,-0.046724457,0.019027187,-0.0072643375,0.014232796,-0.012522937,0.052568406,-0.023811787,-0.07449969,0.041126747,-0.026006432,0.027505742,-0.06324803,-0.020426199,-0.029797731,0.011735208,0.085041456,0.0024943333,0.055649806,-0.0047123004,0.10009768,0.018238233,-0.023271417,0.0050570453,0.009922379,0.0017639794,-0.02532279,0.013649337,-0.06505318,-0.02484432,0.00859589,-0.00490193,-0.04363178,-0.02666392,0.02370507,0.09164877,-0.07694712,0.04283237,-0.07362792,-0.030376904,-0.0041576386,0.003603195,-0.02910776,0.0059250193,0.034807194,0.0545089,0.12627599,-0.0006396459,-0.045994043,-0.010196931,-0.04105757,0.10158078,-0.003648411,0.051028468,0.1361379,0.029327715,-0.015561278,0.015184288,0.012340341,-0.0074862735,0.0688804,-0.017000686,-0.04711606,-0.027050575,-0.01229887,-0.077556975,-0.0087364735,-0.0051612332,-0.034092806,-0.03144177,-0.034149542,-0.047988914,0.0102710435,0.070314236,-0.05686367,-0.056599062,0.009636324,-0.058172207,0.06282308,0.055055372,-0.09261916,0.033485096,-0.05234724,0.011022326,-0.07414089,0.0831585,0.041490212,0.028050382,-0.056515053,-0.02123194,0.03920799,0.03194391,0.013243385,0.021531548,0.10058923,-0.089087725,-0.044710714,-0.09985335,1.4577997e-33,0.02711758,0.02644544,0.047575742,-0.052809898,0.06839472,-0.006405516,-0.03026544,0.02092104,-0.06843344,-0.015549361,-0.09455753,-0.10357966,0.003933985,-0.043954484,-0.052215334,-0.02147049,-0.035309963,-0.047205914,-0.00026051904,-0.039782744,0.056666166,0.012562597,-0.021752829,-0.024992334,0.06716489,0.075770915,-0.09569907,0.013508247,0.02282937,0.0050072963,0.037611794,-0.048345957,-0.0785752,0.012483001,-0.013305293,-0.0020807348,0.058716875,-0.0838598,0.059847552,0.016878862,0.041525003,-0.008786482,0.028210666,-0.033231966,0.060885526,-0.08070331,-0.04710787,0.03794939,-0.028599093,0.07034891,0.11128526,-0.06799518,0.07490796,-0.052663937,-0.048407137,-0.043935675,-0.052308094,-0.005078856,-0.016960781,0.10468669,0.06347684,0.022056187,-0.066549726,-0.004573879,-0.054340582,-0.041165162,0.008526559,-0.056689363,0.018241292,0.092941135,0.028680451,0.021026317,0.12946032,-0.047294676,0.05564624,0.027144799,-0.04078135,0.096950226,0.028638037,0.08317982,-0.0055739633,0.029242486,-0.13083522,-0.038440906,-0.06566996,0.032035995,0.017862571,-0.020567287,-0.07112564,0.05382367,0.0029920035,-0.016801704,0.02449513,0.029174982,-0.015328813,-3.3949078e-33,-0.025793914,-0.05184121,-0.006992663,-0.024266949,-0.0478931,0.049968973,0.053036608,0.018886447,0.014980424,-0.03549764,0.089348465,-0.065933496,0.059475664,0.005249706,0.01776463,0.031434335,-0.07260815,0.05725143,0.038536284,0.02913448,-0.045492887,0.01139348,-0.0088223135,0.101311594,0.15010586,0.0069085155,-0.059780777,-0.014840674,-0.005804857,0.04319098,-0.0333266,-0.030146686,-0.02132829,-0.093825445,-0.009181847,0.04078243,-0.09538946,-0.043192785,0.0670684,0.011412317,-0.015955484,0.07076596,0.05549658,0.041397847,0.0140104825,0.08417035,0.0008781266,0.03836073,0.044806063,-0.010815862,-0.04155124,0.005063433,0.0016963633,0.034094222,-0.04718439,0.09503484,0.046458665,0.023882832,-0.027950127,-0.0072059645,0.024224723,-0.030345758,0.00021631015,0.08276264,0.044325743,-0.011108108,-0.04098725,-0.023361303,0.030010996,-0.021988513,0.026845498,-0.01956671,0.078078754,0.053869165,-0.025123695,-0.018683253,0.0066086724,0.0602372,0.031833358,0.0050984593,-0.022906505,0.006493286,-0.005368012,-0.025063355,-0.030044788,-0.12676945,0.0041340664,0.07449795,-0.0031520328,0.024881016,-0.020038877,0.03427668,-0.0122024715,-0.050173424,0.041346435,-3.702367e-08,0.08707508,-0.062083483,-0.014087269,-0.122786194,0.031480867,0.0026757459,0.012522693,-0.052074634,0.0013156049,-0.014492731,0.004046895,0.10186782,0.000109024084,-0.007333644,0.022019455,-0.023196608,0.05946299,0.024502475,0.018000938,0.019039545,-0.08329254,0.004132943,-0.10238387,-0.064790875,-0.0043693683,-0.03418741,-0.04300272,0.0054002833,-0.06345101,-0.014496299,0.054051816,0.0042320197,-0.0073551475,-0.07086135,-0.010548857,0.12120713,-0.048019722,-0.036113594,-0.036319733,0.04968677,0.0007737246,-0.027109079,-0.009948072,-0.037980884,-0.06622005,-0.0247896,0.15579072,-0.025188642,-0.033881713,0.015369464,-0.008307268,-0.028012762,0.006658584,-0.06419237,-0.04938549,-0.0066902046,0.045418482,-0.058921393,0.02767084,-0.09460453,0.038126133,0.060265362,0.15939797,0.015022088 +3.4.22.42,Cathepsin O is a lysosomal cysteine peptidase of family C1 (papain family). The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32,384,1.0,0.008919309,0.0105127,-0.07666153,-0.018914623,0.05970751,0.02657734,-0.043138176,0.08532643,0.033394758,-0.035004105,0.0043406626,0.0093943775,-0.06208642,-0.0074900948,-0.1264305,0.0137752425,-0.09667275,0.00854139,-0.0011814043,-0.03442018,-0.0028565323,0.024728887,0.010838425,0.04648318,-0.03438746,-0.027595889,0.05125042,-0.00016670572,-0.024310471,-0.027605671,-0.041398488,0.009154918,0.03387412,-0.01562361,-0.00664471,0.043069094,0.068024226,-0.08767885,-0.013607194,0.0071884627,0.051416952,-0.054606553,-0.04346112,-0.047079302,0.022679638,0.03383761,-0.012459322,0.050396543,0.013160441,0.032740574,-0.0037866018,-0.032916818,-0.024438793,0.028153988,-0.026926192,-0.050567057,-0.03904941,-0.06821885,-0.017710548,-0.010698688,-0.027550276,-0.02284347,0.04441301,0.07687863,0.05552764,-0.07966385,0.04539352,-0.060416147,-0.053216334,0.003340878,-0.008081234,-0.055687092,0.03301113,0.065816134,0.02875457,0.09474172,0.04708509,-0.06723902,0.0042627794,-0.029861389,0.06281768,-0.0016978091,0.038086817,0.14824544,0.00016907438,0.011491181,0.04645432,0.033518035,0.034901552,0.0036669872,-0.02053809,-0.08210203,0.0041542007,-0.032257292,-0.09028481,-0.005347887,0.0076466496,-0.0041511683,-0.022951467,-0.027889838,-0.053929206,0.047135282,0.03531237,-0.043272078,-0.08178222,0.03846599,-0.038098976,0.11077392,0.07389826,-0.044898085,0.06161977,-0.076194,-0.018008303,-0.06337177,0.03509146,0.035665274,0.010065901,-0.06677069,-0.03733085,0.036842365,0.009566949,0.021522244,0.0045474605,0.08752556,-0.069157295,-0.03554216,-0.08574554,2.7219593e-33,0.022795368,0.0234437,0.066373125,-0.0712053,0.059796218,-0.00036410068,-0.046165857,0.0011037005,-0.058939368,-0.060857445,-0.1056508,-0.10371994,0.0052787196,-0.022397207,-0.057561133,-0.03063684,-0.036631037,-0.053290766,-0.006188984,0.020049898,0.030675806,0.027057258,-0.040892914,0.031932864,0.07598173,0.06915795,-0.08113093,-0.031079108,0.027606588,-0.009580679,0.035358343,-0.052190717,-0.11202906,0.011909138,-0.05648084,-0.036343716,0.024850398,-0.06352308,0.081943855,0.033222612,-0.00525636,-0.012235196,0.02538139,-0.06287174,0.050488252,-0.05166693,-0.048531547,0.03230917,-0.032389954,0.05567772,0.10316936,-0.03782476,0.048808735,-0.01890067,-0.07978304,-0.06765402,-0.10419919,-0.033987857,0.036796533,0.100070424,0.08516772,0.015822915,-0.016350701,0.03700044,-0.06313047,-0.06949826,-0.017970415,-0.04171541,0.002959987,0.123713166,0.0095830625,0.0026116369,0.117552586,-0.01391576,0.06560575,-0.038697325,0.019358983,0.09291548,0.023451805,0.12390778,-0.009671577,-0.012931226,-0.09307244,-0.027036006,-0.064519845,0.04096617,0.02802457,0.0318762,-0.07607824,0.096256964,-0.008080778,-0.020622041,0.015688453,0.02263735,-0.037632495,-5.2019714e-33,0.024701666,-0.066427015,0.0741978,-0.08585788,-0.047484893,0.04372614,0.048999056,0.030968508,0.007750157,-0.06441487,0.057828408,-0.029405065,0.07201572,-0.0021355418,0.053608652,0.028568238,-0.10575354,0.08463135,0.015807565,0.053923577,-0.054639556,0.017516812,-0.029204395,0.1010211,0.12896752,0.0034598983,-0.056445446,-0.026426686,0.008553772,0.027622726,-0.043932624,-0.02549615,-0.06920723,-0.06172384,-0.019226262,0.073780805,-0.042744406,-0.03712144,0.047517184,-0.0041794567,-0.0454588,0.07178502,0.009079547,0.060474146,-0.011834259,0.095010884,-0.03313815,0.039593395,-0.0015372094,-0.016458193,0.0067480328,0.027258238,0.0030885001,0.0181974,-0.0034050774,0.06598401,0.031358477,-0.012462309,-0.017130207,0.018380016,0.028491199,-0.035009116,-0.031431425,0.09882503,-0.0053989794,0.04256131,-0.018235983,-0.05113457,-0.014547504,-0.02838403,-0.003928476,-0.03462081,0.017439838,0.03538203,0.01917295,-0.0046009053,-0.022094391,0.020683875,-0.011239705,-0.01946905,-0.051263746,-0.041531496,0.0033707374,0.008631906,-0.058194295,-0.11273416,0.046197116,0.10627933,0.00833282,0.05784349,-0.0074955923,0.02963107,-0.005883293,-0.0018130045,0.040757354,-3.9064908e-08,0.08082938,-0.12208882,0.028908107,-0.111911625,0.0013770257,-0.006183523,-0.018226111,-0.03821691,0.0033394662,0.001873822,0.021316882,0.08782926,0.008082241,-0.027504882,0.07510269,-0.0030912717,0.024108764,0.015515831,0.014473294,0.025297599,-0.064591184,0.014274642,-0.095116384,0.0120593235,0.008758516,-0.028616782,-0.015921256,0.009002421,-0.073442705,-0.037583888,0.05573719,0.018248113,-0.00290804,-0.077048115,0.015256652,0.033121195,-0.0056882277,-0.05495569,-0.013291674,0.00014331868,0.0017381543,-0.02947101,0.022533096,-0.051714323,-0.046593145,-0.0006150207,0.09437352,-0.044554308,-0.03008907,0.028802017,-0.0050353156,-0.00827815,0.021442607,-0.084767975,-0.07550515,-0.027969716,0.03395444,-0.106298015,0.03820222,-0.103919856,0.059118725,0.043054238,0.21354868,-0.010207445 +3.4.22.43,"Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2",384,1.0,0.030211812,0.029998364,-0.040507685,-0.05693622,0.09339266,0.057120048,-0.050384123,0.091185264,0.0036145623,0.005879195,0.023729367,-0.02342941,-0.08187634,0.047678426,-0.13449173,-0.017240567,-0.07629649,0.011207692,0.019299481,0.007462451,-0.018261546,0.053079333,0.032910746,0.049890276,-0.030033067,0.011358009,-0.00031499387,0.012727757,-0.045747597,0.020779936,-0.06180091,-0.010159277,-0.042913985,0.024861442,-0.0040983665,0.03895108,-0.0041076406,-0.021621801,0.026603982,-0.020604445,0.032273427,-0.10604889,-0.043321993,-0.020510735,0.017315147,0.09078121,-0.024154916,0.018391844,-0.012214069,0.07824924,0.02535537,-0.051436305,0.029020887,0.02038436,-0.012541825,-0.04227003,-0.0720523,-0.054476988,-0.011730403,-0.041069075,0.023614982,-0.035113465,-0.014339239,0.057831742,0.05152849,-0.06781275,0.055894207,-0.043818552,-0.033023637,-0.026300276,-0.01983615,-0.02877953,-0.03966788,0.08195598,0.025484202,0.12707877,0.025339399,-0.07101534,0.011711041,-0.04878042,0.09224774,0.022384413,0.022621745,0.154705,0.00829602,0.004311949,0.032665458,0.02126952,-0.0030443121,0.038362242,0.0060870317,-0.041946657,0.01295835,-0.011611392,-0.006881001,-0.009181983,-0.03374901,-0.06895597,-0.014448949,-0.03564466,-0.06577943,0.0017529402,0.038620003,-0.06195374,-0.04122598,0.025200833,-0.035108123,0.038021136,0.06278452,-0.108541265,0.048650272,-0.033832744,-0.006111445,-0.07755931,0.08989115,0.0642964,0.0328937,-0.03099691,-0.03350012,-0.022595212,0.023223354,-0.0013257146,0.014509816,0.08528797,-0.07866201,-0.038296584,-0.09855975,3.9016355e-33,0.005802469,0.010348488,0.059955996,-0.04951277,0.061136164,0.043110613,-0.020614028,0.027743246,-0.0834253,-0.018683711,-0.109622255,-0.112637505,0.008679908,-0.0039974195,-0.04844634,0.010152671,-0.03592928,-0.013013498,-0.011132767,-0.057584327,0.04056581,0.018678855,-0.007139209,-0.009471551,0.027403072,0.06563175,-0.06937869,0.005935194,-0.0009834495,-0.016933031,0.03771394,-0.020819228,-0.061747864,0.047019474,-0.04314183,0.036412556,0.05130002,-0.10099001,0.079980336,0.055831462,0.014354299,-0.0024007056,0.011076935,-0.04309849,0.050053522,-0.08535001,-0.050459165,0.0032829589,-0.06723451,0.032314923,0.10113022,-0.07280173,0.024674112,-0.08964925,-0.06036626,-0.032981303,-0.045268577,0.041646637,-0.038064443,0.07924881,0.030491007,0.026943304,-0.051190224,0.029382007,-0.052030504,-0.07565936,-0.0131370695,-0.104187824,-0.025811445,0.088499084,0.03846726,0.02776526,0.113862365,-0.052955955,0.09757993,-0.009608102,-0.062106136,0.11193758,0.0387687,0.09745851,-0.007967941,0.033709433,-0.104770094,-0.036568176,-0.049341876,0.021249052,0.02016864,-0.038637284,-0.040950477,0.061990153,-0.008612575,-0.015461935,0.021751136,0.016148254,-0.037459247,-5.249708e-33,-0.036902472,-0.02439586,0.015821937,-0.005275342,-0.012900307,0.055101532,0.0750353,0.021556882,0.009894504,-0.05707497,0.09411506,-0.051330294,0.056388307,0.033180956,0.013764209,0.044360477,-0.05921485,0.019150263,0.04132309,0.021628033,-0.051105406,0.0025226593,-0.01152686,0.081407785,0.12790734,-0.012250002,-0.024653843,0.018123634,-0.010716422,0.03275541,-0.031621583,-0.0073162364,-0.04898101,-0.084458426,0.021776492,0.0668462,-0.08368383,-0.054970272,0.08052709,-0.0073686177,-0.045138706,0.028702129,0.032341294,0.048835717,0.023655396,0.07724781,0.018704321,0.040816486,0.036791045,-0.0065231873,-0.037348222,0.02569736,0.011916159,0.06551121,-0.010940939,0.09169444,0.0048807585,0.03990594,0.021236725,0.008985317,0.029939903,0.0041845953,0.0049748826,0.09178356,0.02559934,0.034293592,-0.036473572,-0.05854733,0.028176006,-0.07147866,0.03235474,-0.07531704,0.054150637,-0.017942825,-0.026327122,-0.046280313,0.0016935525,0.057557125,0.023974,-0.00023168062,-0.05069829,-0.025684021,0.019999456,-0.030062117,-0.03631925,-0.068009056,-0.008797534,0.11986879,-0.0120634325,0.053056978,-0.015943754,0.026153797,-0.014380912,-0.009426817,0.037724998,-4.1328068e-08,0.10565286,-0.090595484,0.0075014606,-0.1376593,0.022127286,-0.0064933533,0.016699042,-0.036173027,0.01916963,0.009157756,-0.023400722,0.063978024,0.006291871,-0.0011424377,0.046528395,-0.014860477,0.034880396,0.04159504,0.0026235776,0.037746705,-0.07526275,0.010471205,-0.09129755,-0.06794312,0.0037896752,-0.030222734,-0.04676873,-0.0020571367,-0.065125585,-0.045732394,0.10943258,0.02609792,-0.018928468,-0.07446788,-0.014672289,0.100109294,-0.06715117,-0.025257427,0.058161695,0.029726516,-0.035081297,-0.04187391,0.029080406,-0.022607746,-0.06762958,-0.048618697,0.13352473,-0.04731251,-0.028714295,0.004675544,-0.014288245,-0.048806172,0.0121808695,-0.08228783,-0.02226007,-0.007331481,0.08040028,-0.075729966,0.031870212,-0.11116693,0.028819636,0.028048346,0.15535337,0.023975277 +3.4.22.44,"The potyviruses cause diseases in plants, and inclusion bodies appear in the host cell nuclei; protein a of the inclusion bodies is the endopeptidase. The enzyme finds practical use when encoded in vectors for the artificial expression of recombinant fusion proteins, since it can confer on them the capacity for autolytic cleavage. It is also reported that transgenic plants expressing the enzyme are resistant to viral infection. Type example of peptidase family C4.",384,1.0,-0.03300115,-0.0018351132,-0.072619386,-0.020433065,0.061370336,0.08494519,0.001587365,0.07040419,0.031515323,0.056151964,0.05839537,-0.028284516,-0.017953046,-0.005149161,-0.04167222,-0.0099298945,-0.115859486,0.0011826544,-0.0067369547,-0.10187971,-0.02369036,0.044373874,-0.035687122,-0.059362024,-0.012672967,-0.025479956,-0.096515805,-0.02511767,0.023332845,-0.06884468,-0.024898853,-0.081978805,-0.039651114,0.049911696,0.008534773,0.020987019,0.0016898359,-0.03829303,0.016240705,-0.033091847,0.059065163,0.059775032,0.011125579,0.0062256386,0.008805212,0.04569988,-0.029933712,0.034124233,0.096739925,-0.080658734,0.011141037,-0.084621616,0.008576257,0.010539171,-0.006613893,0.0053841705,-0.010447175,0.051435687,0.066543125,0.04663456,0.050108142,0.053951982,-0.01005471,-0.00935859,0.022148348,-0.16122086,-0.05554263,0.08955979,-0.008609174,0.0189965,-0.02180958,-0.047855865,-0.109449804,0.09017389,-0.0030197192,0.089658566,-0.047043994,-0.014185769,-0.019636102,0.057239003,-0.03771033,0.027075198,0.10568139,-0.009233602,-0.009745126,0.019423217,-0.02350695,0.058314055,0.01569739,-0.01826954,0.05645172,-0.103312865,0.08344747,0.047528975,0.023364779,0.065588884,0.103361,-0.16361016,0.081101954,-0.027402313,-0.012386316,-0.08019053,0.006092839,-0.045393497,-0.010251356,0.04651578,-0.033153836,0.0037875446,0.030493023,-0.01859039,0.006658657,0.025502875,0.02729268,-0.09522589,-0.017188447,0.030951992,0.010889846,-0.021538138,0.013093529,-0.048207816,0.004188227,-0.028249338,0.061520565,0.052620023,-0.046220224,0.018897653,-0.057378475,2.5831167e-33,-0.02412462,-0.007477911,-0.00030941985,0.040633127,0.02802998,-0.0191905,0.01307713,0.01553338,-0.013396788,-0.04045971,-0.11672775,-0.09832951,0.036580924,0.015885253,-0.060105987,-0.012058628,-0.023971692,0.0048170253,-0.02723542,0.030699162,-0.0064531527,0.024547413,-0.0074841827,0.022115584,0.06492276,0.026040403,0.026280995,-0.08920904,0.08575187,-0.048895758,-0.041887976,0.029966028,-0.044410117,0.016103156,-0.014819728,-0.0058511146,0.02919422,-0.07053399,0.003235568,0.024246352,0.06551037,-0.023744063,-0.026215568,-0.015486825,0.08931153,-0.039114404,-0.044937663,0.025675625,-0.05183447,0.035614863,-0.002946323,0.0536594,0.036051817,0.012070454,0.001958709,0.029313209,0.0069292397,0.060653485,0.078446604,0.0060938983,0.00044428284,0.028826756,-0.004821837,0.0066114673,-0.03896151,-0.034591004,-0.016086472,-0.03062946,0.020027969,0.17174807,-0.049062822,-0.07473816,-0.02170509,-0.031089934,0.07822766,-0.09058757,-0.073726326,0.034156363,-0.0023716858,0.02442691,-0.03013814,0.06442776,0.048282567,-0.03221995,-0.030785194,-0.048973378,-0.032192763,-0.0417475,-0.08585596,0.019895157,0.11993227,0.023653496,0.0081014605,0.043345667,-0.07387189,-3.2420652e-33,0.0069766003,-0.045839738,-0.008412476,-0.04837498,-0.03678168,0.023334844,-0.025060046,-0.05054205,0.013800261,-0.03427138,0.0068746153,0.0027409445,0.039296538,-0.018208455,-0.057425905,-0.012365421,-0.00603152,0.08761657,-0.033611797,-0.0040414706,-0.103250146,0.049893003,0.04070978,-0.013833034,0.071840905,-0.019976623,-0.02455497,0.090761386,-0.06427781,-0.047899917,0.05987199,-0.0121566765,-0.013969879,0.061036192,-0.038533226,0.038419366,-0.04723396,-0.039163277,0.079448976,0.015149743,0.049360014,0.053159792,0.019783402,0.122494474,0.0039292886,0.0030490537,-0.064601555,0.08450835,0.068509884,-0.003510757,0.0012990389,-0.07781013,0.038264684,0.0108306715,-0.0053602355,-0.072980046,0.032517243,0.040737275,-0.017445775,0.01879669,0.019378286,-0.08264623,0.066587895,0.06187922,0.07328835,0.03582093,-0.03958492,0.11331849,0.038428597,-0.023058735,0.056542076,0.03650284,0.032465033,0.053759653,-0.0170948,0.012072702,0.03173013,-0.034346275,-0.010706765,-0.035460386,-0.080531545,-0.009768526,0.010745537,-0.049211036,0.048284914,-0.03732874,-0.01732314,0.034223627,0.015187376,0.0800594,-0.030971447,-0.043645635,0.01971425,0.059920106,0.104739636,-3.6877996e-08,0.10903728,-0.034902643,-0.008755418,-0.090616025,-0.07039124,-0.02061482,-0.054046206,-0.0091558285,0.0138068255,-0.032009173,-0.021379989,-0.014385199,0.037301872,0.068488784,0.06468594,0.069752365,-0.008961808,0.08430022,-0.0522109,0.022627098,-0.085806824,0.0329934,-0.10189168,0.03833202,-0.021721724,0.009761862,0.0013914781,0.038877543,0.031468734,-0.0748714,-0.02134769,0.024200747,-0.037721954,0.0025623126,-0.046241324,0.06390781,0.049217384,-0.023169553,-0.0048277993,0.0028955278,0.047880072,-0.057811353,-0.06565452,-0.050692324,-0.07686866,-0.03105134,-0.024133656,-0.017225454,0.020142509,0.022669282,0.06895803,0.0076769073,0.038923483,-0.102312274,-0.10102804,-0.02588976,-0.011353159,0.048844617,0.058368675,-0.070936345,-0.084472835,-0.0011846788,0.1923405,0.028113358 +3.4.22.45,"Known from many potyviruses. The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. Type example of peptidase family C6.",384,1.0,-0.050230082,0.026819367,-0.04054488,-0.061527044,0.07309965,0.16229625,-0.064198285,0.02862546,0.04495257,0.025500422,0.081264265,-0.04022343,-0.0096566975,0.05323608,-0.03659217,-0.008463452,-0.08131095,0.01659557,-0.034124378,-0.08445858,0.01297708,0.13028778,0.015531325,-0.06271867,-0.0544886,-0.029158287,-0.07513566,0.032844853,0.05270923,-0.06094828,-0.05607368,-0.046217404,-0.03141319,0.025652109,0.0009881132,0.014547567,0.05071678,0.0009346182,0.0019139557,-0.003716658,0.07247704,0.06899186,-0.01689852,0.014207019,-0.0037909227,0.021531884,-0.025749445,-0.014043089,0.0868613,-0.10093245,0.056805983,-0.022448625,0.01353942,0.008958148,-0.012017587,-0.0046537374,0.003189459,0.0240019,0.016216164,0.012534811,0.027778175,0.0337424,0.00031773912,0.0067155533,0.06946616,-0.11859285,-0.04277614,0.04570276,-0.04829143,-0.04089505,-0.03852033,-0.08224445,-0.08662451,0.07407902,0.013221381,0.063387,-0.075847514,0.016277418,-0.041713778,-0.02775602,0.048810046,0.023640743,0.011742385,0.09199911,-0.022229763,-0.019545557,-0.007691995,0.05130803,0.07212238,-0.042829048,0.01647415,-0.059792645,0.028745541,0.0023078846,-0.06295043,0.05743498,0.090732835,-0.08444854,6.7201013e-06,-0.015558515,-0.0050722463,-0.048837766,0.06591245,-0.11040132,-0.015899768,0.017257571,-0.041833032,0.046255887,0.057982653,-0.026430143,-0.01482358,0.015507599,-0.00041640102,-0.056342307,-0.013356418,-0.028782934,-0.015298131,-0.027772354,0.018521184,-0.084004536,0.00884275,-0.04366405,-0.0043580574,0.13444752,-0.011796822,-0.00458338,-0.07844531,2.1094165e-33,0.04078591,0.008203496,0.012123708,0.009682433,0.029611064,0.035290483,0.04207256,0.034520358,-0.021940455,-0.025917824,-0.019088471,-0.056408178,-0.008809926,-0.009523487,-0.025186103,-0.043475706,-0.026466375,0.019815741,-0.022770192,0.008499319,0.03545195,0.036213685,-0.01591181,-0.003637655,0.11006145,0.031980496,0.018655522,-0.13034873,0.048881683,-0.05814054,0.0040332894,0.05058572,-0.06987975,-0.042170256,0.007519785,-0.063861415,0.059363503,-0.05275989,-0.033109274,-0.03631118,0.01902908,0.002116537,-0.03472916,-0.029306397,0.047043394,-0.08046638,-0.04900579,0.082001016,-0.0623085,0.048498232,0.010472858,-0.01753388,0.08666689,-0.002495718,-0.042816177,0.04518966,-0.0081384,0.040381774,-0.022822835,-0.00929496,0.011316958,0.031210454,-0.022627931,0.0003955027,-0.015053157,-0.08216527,-0.03428496,-0.060073897,0.0829413,0.15955976,-0.0728063,-0.033103593,0.010885446,0.016252114,0.04447121,-0.08951319,-0.1383963,0.04180882,0.028612198,0.045657557,0.0090699615,-0.036318965,-0.0029478783,-0.022669502,-0.032998588,-0.03527618,0.0024554199,-0.023026127,-0.0861944,0.004624613,0.08551769,0.061252326,0.049463715,0.09478915,-0.05390218,-3.094862e-33,0.016777458,-0.0733439,0.08719101,-0.029071229,0.02217133,0.036128107,0.014091345,0.007771395,0.008456751,-0.012326861,-0.021932105,0.005909058,0.060531925,-0.0154499635,0.03864164,0.10368953,-0.032139916,0.13810217,0.010417173,0.022265205,-0.093369916,-0.006580462,0.019952688,0.049646445,0.045717977,0.003781056,0.005724518,0.076247945,-0.05901429,-0.002833239,0.060321975,0.024926888,-0.017657287,0.0055969395,-0.0775,-0.0018308057,-0.003947651,-0.024345983,0.00017442755,0.0020313004,0.021035023,0.078003876,-0.0070901625,0.096510656,-0.029568845,0.029427692,-0.01162918,0.08242621,0.018903684,0.017500607,-0.0063645104,-0.07864255,0.011513523,0.041417733,0.008118792,0.034287054,0.026889216,-0.013453484,-0.031351093,-0.0013692408,0.015051109,-0.03345752,-0.041383844,0.046646845,0.05154248,0.032919973,-0.009661959,0.0104540605,0.046870254,-0.07949243,0.044296544,-0.0071218694,0.06090899,-0.007121765,-0.020506145,0.056442585,0.02510066,-0.12700859,-0.004333437,-0.035432775,-0.074280895,0.012975561,-0.02637191,-0.053174265,0.010751723,0.004747205,0.019484574,0.07179631,0.0075443117,0.048726015,-0.021705536,0.006672585,0.045351602,0.10075319,0.08468912,-3.6406483e-08,0.07008925,-0.0900839,-0.019027822,-0.11888568,-0.06261755,-0.040555775,0.026695468,0.026193446,0.024714315,0.021285724,0.05334063,-0.04441778,-0.0059611043,0.06262665,0.09205532,0.0026183194,0.06240288,0.12841351,-0.061051026,0.08023544,-0.044215214,-0.0057879407,-0.069700725,0.005663962,-0.033442903,-0.033185698,0.0076598926,0.0787695,0.018719014,-0.034707587,-0.013597466,-0.023547748,-0.04705519,-0.0009469975,-0.05582628,0.07374833,0.024114152,-0.081768386,0.010800073,-0.036484033,0.05938113,-0.07826079,-0.05148935,-0.038549893,-0.018334644,-0.055326533,-0.017611826,-0.032714773,0.017039746,0.0008943966,0.017265173,0.0062137223,0.019403823,-0.13837454,-0.10406912,-0.01222744,-0.002337901,-0.021239672,0.08459515,-0.0573697,-0.028925203,-0.005117434,0.17692854,-0.016198577 +3.4.22.46,"Best known from foot-and-mouth disease virus, but occurs in other aphthoviruses and cardioviruses. Destruction of initiation factor eIF-4G has the effect of shutting off host-cell protein synthesis while allowing synthesis of viral proteins to continue. The tertiary structure reveals a distant relationship to papain and, consistent with this, compound E-64 is inhibitory. Type example of peptidase family C28.",384,1.0,-0.08497129,0.00062077737,-0.051527005,-0.047900733,0.07428564,0.028571347,-0.057962924,0.09246494,0.078437254,0.080330245,0.03482249,0.011327214,0.0026722555,0.037731573,-0.044548955,-0.027268974,-0.11793849,0.004361471,-0.0063570407,-0.029352108,0.008094815,0.06489761,0.035972334,-0.007872564,-0.07803914,0.014733992,-0.007859064,0.012298774,0.06636131,-0.05998237,-0.012512892,0.003945362,0.06495398,-0.004104485,-0.0073851943,0.098058924,0.014433987,-0.054322906,-0.056255747,0.034373026,0.09518875,-0.006691375,0.022225952,-0.034254253,0.06869347,-0.022236107,-0.09490017,0.057089053,0.015882524,-0.045975767,0.0047827205,-0.09188594,0.02009434,0.036466878,0.026249358,-0.058674138,-0.0398808,-0.0254739,0.05285141,0.029651802,0.017584238,0.048861828,0.024252431,-0.00256215,-0.002130873,-0.07476831,0.03546939,-0.026148286,-0.020089647,0.06941656,-0.035787996,-0.059671998,-0.03249811,0.119079255,0.037299152,0.08027665,-0.0662241,-0.038442884,-0.0068317573,0.010922914,0.046105463,-0.022332804,0.0876345,0.03317858,-0.05163947,-0.007006613,0.010162938,-0.021249106,0.050918024,0.0018352476,-0.04264301,-0.03966252,0.037165977,0.030572325,-0.011136542,0.030341946,0.038626246,-0.06324173,0.024297617,-0.00027075358,-0.025114028,-0.024653519,-0.07686963,-0.02223093,-0.009565695,-0.059962083,0.026267141,0.10972934,0.03963906,-0.01698823,0.0070445426,-0.04282128,0.004803865,-0.12952818,-0.042342037,0.019950984,-0.038894624,-0.02469509,0.039194103,0.0040117907,0.01719747,-0.024937188,0.0023987945,0.036213342,-0.11205354,-0.070295855,-0.09666414,4.8063567e-34,0.04530592,0.011247481,0.021197611,0.03393973,0.03662926,0.020139495,-0.030852806,-0.0034769245,0.0030185354,-0.07162924,-0.03918509,-0.051260915,0.031981103,0.0329935,-0.05105299,-0.042573966,-0.037054684,0.0509209,-0.038921293,-0.009571754,0.11179687,0.023217645,0.0018776378,-0.042859074,0.100375034,0.057336118,-0.0792479,-0.04363717,0.05385199,-0.025364904,-0.038579077,0.02026065,-0.098337926,0.017105475,-0.030874044,-0.042553347,0.027293643,-0.048369534,0.0056522186,-0.007967659,0.057844017,-0.0040591983,-0.023980906,-0.06923933,0.057499073,-0.102408834,-0.06737643,-0.0202599,-0.043832276,0.018453661,0.06448228,0.0055332463,0.08102067,-0.0013463096,-0.107725546,-0.024617752,-0.028916832,0.014902663,0.03030846,0.010910111,0.06998169,0.06531162,-0.011190394,0.025180953,-0.050959777,-0.04395505,-0.012728188,-0.04872598,-0.059309553,0.11858684,0.046156857,-0.06325905,0.040084217,-0.029751107,0.040888533,-0.037277546,-0.08101846,0.0892759,-0.005237043,0.047621418,-0.034889523,-0.00031748458,0.04207562,-0.011541393,-0.09260079,-0.05869421,-0.0029946123,-0.03939492,-0.07499621,0.044486605,0.06734573,0.02296994,-0.010969868,0.06351674,-0.005452412,-3.1150152e-33,0.06519502,0.026207788,0.06732925,-0.085160546,-0.037372634,0.06484033,0.078731455,-0.007911881,0.07626696,-0.051764406,0.09305992,-0.014228041,0.01854931,-0.0114714205,-0.005059352,0.055046447,0.008892278,0.068811595,-0.05248573,0.017896552,-0.033810355,-0.029745555,-0.039197847,0.024601407,0.054285493,-0.013274305,0.047580127,0.061727967,-0.11982848,-0.022423543,-0.016751507,0.006856054,-0.06481432,0.064510286,-0.07933434,0.026914192,-0.042425968,-0.054061323,0.017487584,-0.10358024,0.09017551,0.057134423,0.035671324,0.08226099,0.037958123,0.054807685,0.02940809,0.08697433,0.08107555,-0.015359945,0.0054296786,-0.032617334,-0.009626838,-0.00062679255,-0.05854349,0.022259422,-0.0132568935,-0.002728962,-0.048250183,0.009356548,0.053902145,-0.024839547,-0.028587198,0.07868827,0.069906294,0.03627552,-0.0034989505,0.05362828,0.096365,-0.10135913,0.041186452,0.04419291,0.013886618,0.027138256,-0.018921912,-0.0026155508,0.008624136,-0.093407094,-0.01426672,-0.08739989,-0.033604108,-0.04616555,-0.038538918,-0.039153222,0.027286313,0.004770967,-0.024538819,0.019140042,-0.0130289495,0.050025295,-0.03491203,-0.0058575864,-0.0047518983,0.07512032,0.012493163,-4.6341732e-08,0.08105127,-0.053711567,0.0012719875,-0.06600262,-0.010999596,-0.042864874,-0.05524577,-0.011872039,0.097841635,-0.04524745,-0.02500354,0.06573335,0.02366895,0.022862678,0.012028048,0.037167843,-0.06902223,0.052426547,-0.020848792,-0.024960108,-0.09513959,-0.017323585,-0.033301782,0.019809388,0.013141659,-0.046249148,0.025060873,0.044611923,0.03986594,-0.07188805,-0.0048821624,0.043406025,-0.06109999,0.00071360933,-0.020799711,0.06908361,0.009789411,-0.050603975,-0.052390374,0.01843667,0.08330322,-0.019375384,-0.06256525,-0.06339603,-0.06412089,0.008038723,-0.03230917,0.010108494,0.023916924,-0.03676612,0.056502946,0.060898166,-0.0134175075,-0.06985805,-0.070678934,-0.05253343,-0.004726487,-0.015802413,0.11646682,-0.07401524,0.09275387,-0.08591645,0.18924534,0.07566209 +3.4.22.47,Activity is stimulated by glycine. Known from the bacterium Porphyromonas gingivalis and contributes to the pathogenicity of the organism. In peptidase family C25.,384,1.0,-0.022377558,-0.058678318,-0.09380859,-0.06442675,-0.030789763,0.07159758,0.0015447498,0.048217073,0.060337227,0.0981814,0.01074241,0.03734437,0.014115687,0.092324845,-0.039711382,-0.031257436,-0.014551324,-0.016136752,-0.06261541,-0.011312543,0.05714433,0.05009256,-0.03833136,-0.048784148,-0.05205253,-0.023651341,0.0013206282,-0.043055538,0.021511238,0.0067480966,-0.031174725,-0.029868983,0.04037131,-0.12384633,-0.001101356,0.06010617,0.0046645887,-0.035378918,0.11954844,0.06897765,0.005793701,0.011137796,-0.0060254284,-0.0069132037,-0.0023176488,0.013491072,0.027802851,0.04997355,0.07088991,-0.04914713,-0.025283528,-0.02986637,-0.010714998,-0.02308859,-0.00070261443,-0.036215957,-0.07649479,-0.04374398,0.050589055,-0.017625764,0.006219945,0.018925034,0.05084554,0.015062327,-0.06467816,-0.097958624,0.04856628,0.0107949395,-0.01266008,-0.017981417,0.048539683,-0.045244306,-0.020443358,-0.036136694,-0.032839067,0.046058264,-0.06719724,-0.0106712915,-0.023084266,-0.020537728,0.05292439,-0.017972002,0.067567125,0.10796179,0.023245838,0.0005843349,0.046871,0.03995174,-0.0036845796,-0.0017895914,-0.0033445603,-0.06957376,0.04429854,-0.0023513176,-0.045820586,-0.016808424,0.025248768,-0.06383023,-0.026106842,-0.0036245529,-0.07676384,0.023412775,-0.045548063,-0.017517563,-0.014442497,0.037201747,-0.044633277,0.084770344,0.058832847,0.024190316,-0.005625748,0.056518577,0.0068779793,-0.04316028,0.008255282,0.072330445,0.043137614,-0.012224944,-0.016405893,-0.0093196435,0.07006295,-0.029482879,0.010364663,-0.0065165395,-0.060331456,0.036556557,0.0002860948,-1.0545781e-34,0.060159262,-0.03884954,0.069759876,0.045567423,0.036838833,0.058391698,-0.086158395,-0.03481688,0.07122795,-0.058573116,-0.06962831,-0.00837529,-0.02847745,-0.0024274134,-0.059651084,0.09525995,-0.10479628,-0.022791013,-0.005165231,0.030944893,0.040446874,0.04654626,-0.021545593,-0.0024010886,0.05295544,0.044074345,0.04765628,-0.06300503,0.012218718,-0.00054461736,-0.030466476,-0.115018144,-0.06866709,-0.055490512,0.07196584,-0.046447463,-0.01455449,-0.043816686,0.05014972,-0.050235778,-0.034200195,-0.030453604,-0.054079756,-0.029261522,0.03308576,0.053469434,-0.057255846,0.05029937,-0.031628102,0.03548533,0.08263347,-0.051026616,0.029363044,0.07496569,-0.100031845,0.010168903,0.030863207,-0.045633517,0.012764418,0.06784288,0.04225416,0.018901788,0.026877599,-0.0022553797,0.036319878,0.018094089,-0.07037232,-0.0056609176,0.024507917,0.0703126,-0.06090788,-0.04808063,0.012957234,0.018939404,-0.042972762,-0.09426306,0.060389265,0.031531367,-0.024955513,0.040218744,-0.0131442165,-0.057280216,-0.008189519,0.049770255,-0.06474003,0.011321397,0.016104152,-0.05999108,-0.033321343,0.0061273794,0.07260716,0.027975546,-0.026592683,0.018951872,-0.09678443,-2.005046e-33,0.09559035,-0.10452812,0.075903386,-0.063472465,-0.024114063,0.09049657,-0.060878552,-0.020842452,-0.023431987,-0.009844088,0.0052070534,0.036058832,-0.024217721,0.017585576,-0.04305729,0.03105584,0.043973006,0.04522327,-0.1424177,-0.0018677051,-0.076211326,-0.0009732154,-0.005929058,-0.05523084,0.038761,0.035714857,-0.033984393,0.032044727,-0.021084046,0.06113631,0.046795994,0.074751616,-0.105099216,-0.041598566,-0.018075947,0.06767542,0.01634248,-0.032588243,-0.06827308,-0.11975164,0.010504673,0.046788912,0.05384677,0.1351621,0.052687835,0.1022583,-0.052515037,-0.039690185,-0.1062241,0.033675205,0.038547374,-0.016320676,-0.007886103,0.040117316,0.02308298,-0.025576847,0.026303096,-0.010139405,-0.019973109,0.06567803,0.05767319,0.002249926,-0.04266691,0.016225277,0.04615772,0.010123635,-0.026058821,0.05862066,0.11445879,0.008607204,-0.0023963323,-0.016967727,0.05201518,0.010939354,0.014599101,0.124232054,-0.10097773,-0.08495955,0.018799027,-0.016418254,-0.050192453,0.042038273,-0.03911553,0.0048031705,-0.022895688,-0.07753425,0.04023071,0.13692749,0.055105973,0.07360031,-0.07195821,0.027478185,-0.022842174,-0.010407058,0.072708674,-2.8887387e-08,0.014429184,-0.021991968,0.04068756,-0.051858634,-0.079270005,0.018686365,-0.07298254,0.066906,0.06615762,-0.029008053,0.010352922,0.0066344803,0.041139226,-0.018149462,-0.008165664,0.12328179,-0.012804928,-0.0007221331,-0.008553836,0.0055263885,-0.09340303,0.010505833,-0.069035746,0.047557928,-0.058168642,-0.083609,0.029419318,0.07630594,-0.022611132,-0.057974067,0.040805202,0.02435405,-0.052719656,-0.015367349,-0.0939445,0.024516802,0.0047363476,-0.024715703,-0.022579676,-0.0422752,-0.046330847,-0.011842843,-0.10541595,-0.017431825,-0.048626043,0.022232324,0.0084910495,0.07112143,-0.0313959,0.042296365,-0.0006704028,0.046478704,0.038659744,-0.047904115,-0.16629109,-0.0096583525,-0.048794337,-0.037173428,0.03250485,-0.078015216,-0.048347227,0.015914539,0.117574856,0.0407817 +3.4.22.48,Known from species of Staphylococcus. Type example of peptidase family C47.,384,1.0,0.006465537,-0.04383421,-0.13255933,-0.033190418,-0.009212754,0.052630752,-0.07441135,0.05310805,0.034482982,0.021132113,0.09582004,-0.1056909,0.012183181,0.044405706,-0.018149093,-0.03747298,-0.11093795,-0.06626114,0.030165374,-0.05134973,-0.002411982,0.08533154,0.028500121,0.022662299,-0.08583703,0.008017941,-0.019284366,-0.017805392,0.045986213,-0.054392118,-0.034731723,-0.063068554,0.1125271,-0.013963011,0.109164596,-0.0166136,-0.04710257,0.0074770893,0.1141955,0.055367164,0.005727868,0.055989303,0.03732281,-0.02818123,-0.0056293188,0.00792539,0.016982751,0.11251325,0.053174127,-0.07118448,0.020321613,-0.036319375,-0.048457664,0.017105298,0.05728438,-0.034124777,-0.08560412,-0.06754248,0.04314225,-0.018323487,0.039953064,0.018284865,0.029861193,-0.06208132,-0.07827947,0.027777841,0.006507431,-0.034849714,0.12168429,-0.02673619,-0.04960671,0.0026811352,-0.02863146,0.13619518,-0.047262575,0.058661625,0.026633263,-0.06906885,-0.08883547,-0.0042306962,-0.07373749,0.037804384,0.036344692,0.061372902,0.048352696,0.012811153,0.023229308,0.0010452069,0.015400282,-0.04029529,0.030075474,-0.080119334,0.02591962,-0.033011008,-0.08043589,-0.055877756,0.066380195,-0.010648065,0.032159843,0.013254391,-0.009330775,-0.050149243,0.044138752,-0.01086485,0.009200823,0.04911374,-0.061120026,-0.029133309,0.050596092,-0.014475782,-0.023877285,0.03612312,-0.11093791,-0.10628234,-0.003571768,-0.026493082,0.030564949,-0.023402493,0.016135484,-0.02259856,0.0012129878,-0.009081182,0.022945134,-0.04702931,-0.06008561,0.02642466,-0.07576257,6.3268853e-34,-0.065546565,-0.026551908,0.094700925,-0.011649243,0.06017478,-0.013613438,-0.048090365,-0.0023679927,0.0361817,-0.093020074,-0.07932276,-0.02649661,-0.012168973,-0.02431452,-0.031188343,0.041168176,-0.06233159,0.0005154126,-0.031180082,-0.008021714,-0.026432665,0.11833792,0.029959107,-0.041575745,0.08623304,0.0079240445,0.03312713,-0.017865289,0.09160323,0.0040958812,-0.04767948,-0.004631002,-0.09904277,-0.040897567,0.028555745,-0.015243431,-0.03978408,-0.06394654,0.023669085,0.016534915,0.01114528,0.016967706,0.021284545,0.032413352,0.050494287,-0.029624281,-0.022841845,0.026253713,-0.011943868,0.017873157,0.0054105353,-0.012434328,0.0068270066,0.022488527,-0.026731143,-0.013363954,0.041620243,0.03610864,0.089842126,0.116523445,0.0883474,0.050589707,-0.015951585,0.030995136,0.04529991,-0.0014604058,-0.07485733,0.047488127,-0.0076753586,0.061711993,0.0002361114,0.029406505,-0.004783935,-0.030998725,0.03388377,-0.08182329,0.005511072,0.062462505,0.037124444,-0.021598868,-0.020001154,0.0313192,0.030873831,-0.020017203,-0.116466455,0.015810395,-0.032604486,0.02371279,-0.060608987,0.056059822,-0.0062211645,-0.021770872,-0.00969934,0.037366003,-0.02988245,-2.976484e-33,0.041753083,-0.066681065,0.033840917,-0.100162126,-0.034003723,0.0906119,0.030560397,0.03359116,-0.04730735,-0.03548832,0.035471283,0.012633606,0.0036061986,0.0039445837,0.038014792,0.018640118,0.0111797135,0.062178813,-0.04799398,0.033840615,-0.053515248,0.0034547462,-0.03388573,-0.03511419,-0.0011142478,0.02648266,-0.035841327,0.041161027,-0.019399699,-0.087055705,-0.030819844,0.012463216,-0.023663657,-0.04295524,-0.077916324,-0.009362095,-0.0073277303,-0.016101388,0.014410526,-0.035457402,0.0150576485,0.029179752,0.05188585,0.097931586,0.0252527,0.05905307,-0.045911696,0.008974327,0.013494699,-0.0001996907,0.035740897,-0.060204133,0.0013539108,0.013246159,0.013343423,-0.06497402,0.0025802846,0.037497237,-0.034820598,0.034026835,0.015102461,-0.06270818,-0.05871394,0.09964315,0.103544526,-0.06662404,-0.09941258,-0.06964065,0.07275896,-0.022798585,0.020169942,-0.0218193,-0.026424734,-0.07704183,-0.027195519,0.0476978,-0.036169793,-0.050123725,0.036764998,-0.011148519,0.009539111,-0.06493707,0.0529834,0.092445634,-0.015714338,-0.05110887,0.039242692,-0.03860351,0.03471758,0.11264259,0.03342014,0.021809198,0.0075380313,0.0847281,0.059946567,-2.3130228e-08,0.10044239,-0.044448953,0.02545208,-0.011141216,-0.044943027,-0.019658558,-0.108856544,-0.035869572,0.016704774,-0.0010766191,-0.016081488,0.0012293702,0.013900036,0.019645285,-0.028620055,-0.002982686,-0.090646945,0.010748879,0.032692984,0.05661981,-0.13487525,0.0077592786,0.0024384882,0.045772456,-0.038884316,-0.040600147,0.08945544,0.06327051,-0.029996367,-0.025386501,0.03295175,-0.0026034974,-0.06843221,-0.053602457,0.060149163,0.0018569736,0.008345642,-0.037268206,-0.015802149,0.00020478836,0.08126388,-0.042592652,-0.09876055,-0.025668137,0.0022941637,0.03651794,-0.035244294,0.03227965,-0.042434968,0.029348688,0.030748911,0.042027757,-0.014446702,-0.007912432,-0.15452732,0.0036929653,-0.019325398,-0.0571713,0.008540878,-0.026053851,0.07204358,-0.040030945,0.1540266,0.16823009 +3.4.22.49,"In both budding yeast and human cells, cleavage of the cohesin subunit Scc1 by separase is required for sister chromatid separation in mitosis. Budding yeast separase is also known to cleave the Rec8 subunit of a meiotic cohesin complex and the kinetochore protein Slk19. Type example of peptidase family C50.",384,0.99999994,-0.122423016,-0.04827762,-0.101480834,-0.12893763,0.040828746,0.051341683,-0.008467021,0.036673076,0.014952609,0.060136944,0.10251276,-0.045084294,-0.061744504,0.0054774275,-0.027695121,-0.044974707,-0.05951152,0.0033165792,-0.08098754,-0.06549623,0.073126346,-0.0061966125,-0.013687818,0.079025194,0.052144013,-0.033630032,-0.0017236797,-0.04527327,0.05024461,-0.03590314,-0.028430745,-0.06833225,0.009595213,0.014122123,0.064761385,0.042146426,0.024671417,-0.06173369,0.085526444,-0.0014292907,0.04165336,0.016950542,-0.04405244,-0.03754409,0.042560596,0.07924868,-0.014585877,0.054448906,0.020986116,-0.053282615,-0.04937717,-0.0224176,-0.027815158,0.10293753,-5.920825e-05,0.049521476,-0.05951722,-0.007407087,0.096053414,0.063661106,-0.06998241,0.031288747,0.050680466,0.014933408,0.03221098,-0.108703636,0.016502485,0.043967158,0.03558076,0.03755788,0.08631808,-0.03592962,-0.10104138,0.0067711603,-0.003313485,0.11457784,0.024299478,-0.07929091,-0.104628086,-0.009240212,-0.031781834,0.025740635,0.14672413,0.045056574,0.014944195,-0.036301296,-0.020854276,0.012814939,0.022720959,0.0042174407,-0.023764934,0.0008594431,0.077160545,-0.008640278,0.021264182,0.025447935,0.052234147,0.019244816,-0.021392085,-0.0064676814,-0.03003387,0.063813396,0.045688916,-0.07434539,-0.03126714,0.061921593,-0.035383366,0.062428296,0.054000452,0.016882353,-0.0422462,-0.011917485,-0.011254781,-0.010836486,0.012649888,0.00198184,0.0950448,0.024937535,0.12765867,0.016925577,0.031081408,-0.042599577,-0.04552415,0.041048154,-0.02433662,-0.013557665,-0.043903925,4.195922e-33,-0.052573048,-0.03601714,-0.03314445,0.09224048,-0.037767146,0.015462826,-0.096306644,-0.03554077,-0.070503026,-0.059372623,-0.08122223,-0.03893196,-0.020981792,-0.038268343,-0.07979196,-0.01435484,-0.041957248,-0.03576609,-0.04487202,0.0085398145,-0.014999512,0.08256922,-0.03400644,-0.06087462,0.06604336,-0.016860707,0.046923246,-0.026727997,0.029242108,0.018382734,0.007804331,-0.019308353,-0.03741052,0.03287732,0.008145546,0.0736862,-0.011798599,-0.07270269,-0.05546237,0.04711208,0.019105732,-0.06358383,-0.053020284,-0.030689245,0.021440804,-0.054997932,-0.020796686,0.017194692,-0.019716654,0.02320037,-0.021913283,0.046831585,0.052094102,0.020687686,-0.061615843,-0.02353424,-0.0003053291,-0.024267955,0.077843785,0.0124085,-0.01005528,-0.018364241,-0.04182254,0.12234959,0.053196102,-0.030757954,-0.100797825,0.017232427,0.033440962,-0.0074756755,-0.09864324,-0.0129724685,0.048016597,-0.020414457,0.010114571,-0.059308268,-0.015636569,0.017555773,-0.037324008,0.04018295,0.06980378,-0.04024988,-0.011700086,-0.028761283,-0.04422186,-0.0065444065,-0.02453725,0.034791265,-0.09154103,-0.07940048,0.07669866,-0.052221514,0.030966412,0.044633813,-0.045517553,-5.6815315e-33,0.04622784,-0.071822934,0.075245544,-0.08764382,-0.09146858,0.094843075,0.04177878,-0.046630904,-0.09528491,-0.023401368,0.0413766,-0.044112857,-0.035303604,-0.021212744,-0.024654683,-0.0026093395,0.017137092,0.03762055,-0.004430287,0.0063322973,-0.0513376,0.03172271,0.018383186,0.08204039,0.023481077,0.025636524,-0.0632279,0.09931648,-0.013939029,0.017382141,-0.064503,-0.039767027,-0.0023274627,-0.01541312,-0.022708315,-0.045981865,-0.07623586,-0.0051092072,0.070573725,-0.053398363,-0.000968616,0.03626795,-0.072952434,0.03500798,0.044780556,0.10523538,0.043383736,0.08951415,0.030136896,0.022282671,-0.043061268,0.0047641722,-0.035453293,-0.007835954,0.067898445,-0.045319937,0.0062851054,0.02545287,-0.009729127,-0.013453848,0.051545102,0.02150018,-0.029017715,0.086769626,0.10911094,0.032820515,-0.07023827,0.024736341,0.0565116,0.016192185,-0.04695976,0.013724012,0.07871975,-0.0013466547,-0.021174284,-0.038606964,-0.04744551,-0.052111935,-0.03409266,-0.02813769,-0.07033806,-0.09464774,0.01407632,0.00016665422,0.032295443,-0.09725089,0.016857399,0.03618533,0.019653967,-0.021017741,-0.017619384,-0.01033272,0.032534175,0.073265284,0.059499666,-3.2586865e-08,0.1630162,0.059521243,0.014756663,-0.06923718,-0.027895873,-0.00966309,-0.06525912,0.015646443,0.014194736,0.021099862,-0.055385713,-0.0614943,0.04377022,0.072556004,0.029461974,0.025655728,-0.009058007,0.08591849,0.038517445,-0.0380824,-0.010821755,-0.033605244,0.06236695,0.09111346,-0.07976493,0.01895478,-0.025422117,0.12766345,-0.030239465,-0.09298897,-0.016255585,0.023537967,-0.022369083,0.01446697,-0.022001496,0.14105456,-0.05006338,0.0030299213,-0.0022485754,-0.014042948,0.030411495,0.0023973426,-0.020717183,0.009776924,0.017600125,-0.054516066,0.123612925,0.008475135,-0.012388045,0.014964138,0.0021466818,0.028188372,-0.02675915,-0.057729255,-0.05548916,-0.038740583,-0.022570677,-0.05143673,0.014127725,-0.048426565,-0.009025537,-0.0014058768,0.03668076,-0.04561396 +3.4.22.50,In peptidase family C1. Contributes to the liquefaction of the tissues of the insect host in the late stages of infection by the baculovirus.,384,1.0,-0.064973086,-0.068139605,-0.04968205,0.011849471,0.043119032,0.082153745,0.017206635,0.0012552348,-0.006870156,0.063404396,0.07029616,-0.01747432,0.060384784,0.075170375,-0.07496299,0.024258526,-0.04114748,-0.04572885,-0.033792883,-0.040545452,-0.010306198,0.044438716,0.06428035,-0.0013839735,-0.08936121,-0.014909912,-0.059335474,-0.04680481,0.055622205,-0.03765714,-0.013273538,-0.0024996973,0.02106694,-0.025923159,0.04288999,-0.01110839,-0.022258265,-0.005780115,0.032074384,0.03130687,0.081582956,0.09191526,0.003714674,0.0010329648,0.006623931,0.011498558,-0.00084060186,0.069728,0.10904277,-0.060221624,0.033881515,-0.004557106,-0.054205738,0.042895656,-0.04728958,0.025046777,-0.0548544,-0.03054017,0.04479894,-0.012192547,-0.038450472,0.14384937,0.032256715,-0.0005016185,-0.029340584,-0.14498141,0.013024146,0.035282582,0.01633677,0.048453297,0.041158758,-0.021025807,-0.06705447,0.094285615,0.036935005,0.04658432,0.022765223,-0.07420156,-0.080047034,0.023723686,-0.06681439,-0.068069436,0.121257536,0.0798195,-0.07899771,-0.09712743,0.028966058,0.0031220117,-0.0069182315,-0.026293077,0.07342698,-0.10488847,0.05468809,0.035164066,-0.06963942,0.061010268,0.0622002,-0.040226962,0.05323371,0.037268393,-0.07116831,-0.12802124,0.033625904,-0.011723921,-0.031731475,0.027354116,0.009975502,0.026585706,0.10429691,0.044327296,0.060341362,0.017328652,0.06976827,-0.031588256,-0.034296162,0.009213028,-0.06500518,-0.023362458,0.075450845,-0.040501177,0.07676357,0.0074786562,-0.024979375,-0.012447975,-0.021156056,-0.014826421,-0.027517779,-2.4070225e-33,0.022134313,-0.083847634,0.025659947,0.025101485,-0.03704685,0.038891457,-0.029567497,0.02113843,-0.0041466705,-0.04141769,-0.06647779,-0.027368011,0.017770449,0.050847698,-0.12717427,0.082574,-0.09114057,0.005643618,0.062416654,0.057958264,-0.017670343,0.033739287,-0.015205861,-0.08278318,0.09968704,0.05808064,0.004312659,-0.015485054,0.00469433,-0.014409055,0.014894536,0.05695858,-0.10706399,0.034436002,-0.042519893,0.048989754,0.030387854,-0.07274791,-0.07955606,-0.052117955,0.011217599,0.0116381785,-0.07415418,-0.05722866,0.091079235,-0.06276361,-0.08716235,0.02886294,-0.0046721436,0.05479189,0.050699074,0.015607163,0.11759152,0.034164764,-0.06484241,0.03759745,0.073086016,-0.032156706,0.05212556,-0.04090327,0.116607875,0.007947851,0.021047214,0.021129522,0.09761419,-0.047091424,-0.011829378,0.028702263,-0.0082125645,0.00016970388,-0.05539286,-0.0008144678,-0.017137514,-0.041286584,-0.014850039,-0.047050774,-0.071064085,-0.028329374,-0.042123415,0.023819314,-0.04228159,-0.044426948,0.14323817,0.011031194,-0.017790463,0.00986101,-0.012778871,0.03197895,-0.05039954,-0.01708801,-0.010671059,0.0046951976,0.015958568,0.089320935,-0.054111622,-1.1956082e-34,-0.0027176936,-0.04416123,0.013695441,-0.04251429,-0.04923448,0.055974565,0.06325504,0.02083673,0.023057006,-0.008526549,-0.017316299,-0.028049896,-0.019562075,-0.05164045,0.043875318,0.026686858,0.015387914,0.052337542,-0.059402954,0.010915288,-0.12919474,0.03563881,-0.012513184,-0.02463573,0.00066145015,-0.0913322,0.04239075,0.022929614,-0.068156645,-0.022258675,0.013368711,-0.0027299887,0.0058059613,0.018874127,-0.003224993,-0.012970213,-0.04183331,-0.02402231,0.026375266,-0.03147987,-0.0065144305,0.07071075,0.010561547,0.054120578,0.04964584,0.0811893,-0.049514256,-0.016015513,0.052304864,-0.0005046379,-0.03784678,-0.08590752,0.0096997665,0.007283017,0.01065542,0.0066280197,-0.021227743,0.04675647,0.06536141,-0.015078791,-0.0071263583,0.021563623,0.019421935,0.0045469464,0.012218548,0.10558719,-0.06941892,0.107208446,0.07343076,-0.042496435,0.0027765338,0.024541836,0.0037431,0.014556405,-0.03135117,0.040163297,0.016142039,-0.040532142,0.035211295,-0.0073124967,0.02854228,-0.028213663,-0.01121855,-0.009584376,0.024277505,-0.04592681,-0.035705473,0.023391241,0.03772886,0.016991736,-0.018804176,-0.06900767,0.08669652,-0.024300173,-0.035018377,-2.641487e-08,0.031739347,-0.03571816,-0.05086503,0.0145562515,-0.0554038,-0.009776174,-0.05282826,-0.020256849,-0.0057519516,0.029450342,0.077613585,-0.05563526,0.0042610834,0.06967202,0.0648758,0.10128729,-0.08288273,0.04966406,-0.03879548,-0.003542177,-0.08047832,0.020555826,-0.07135692,0.052538563,-0.032258693,-0.06592103,0.00017493634,-0.009110062,0.016229691,-0.06197355,-0.06661107,0.036175683,-0.0554296,-0.06280239,0.011073421,-0.0015691232,0.03744985,-0.04771403,0.10190207,0.010118879,0.115192726,-0.032296725,-0.038843695,-0.12942998,0.0022062738,-0.046693332,-0.04213697,0.037559748,-0.021034487,0.01185497,0.056106966,0.013594351,-0.06251615,-0.057313006,-0.106179744,-0.0206307,-0.0083152605,-0.060628824,0.033795033,-0.06707695,0.018375328,0.007887369,0.12306171,0.034449298 +3.4.22.51,In peptidase family C1. Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins.,384,1.0,0.039007135,-0.014299576,-0.12471941,-0.08612618,0.03926183,0.003260081,0.04913741,0.039667863,0.0632262,0.020418392,0.090987585,-0.064856485,0.00038958943,0.044814173,-0.086932056,-0.063913524,0.010840145,-0.02848773,0.022106793,-0.07606552,0.029284004,0.090796635,0.07126619,0.007325872,-0.12994617,-0.027014215,0.004581387,-0.019200526,0.030440237,-0.0485491,-0.049088623,-0.04237446,0.019194797,-0.013222303,0.060521193,0.011703668,0.008197647,-0.0063832593,0.08586748,-0.0179275,0.01750779,0.031801153,0.008233603,-0.043793894,-0.03381564,-0.010276751,-0.0076036933,0.07545496,0.09416176,-0.05313787,-0.050376,-0.07393157,-0.027487688,0.041477174,0.019254226,0.10455263,-0.03370609,-0.03376428,0.056935675,-0.020673925,0.019439256,0.03446623,0.00058782287,-0.013547759,0.044701837,-0.084325135,0.0074645174,0.042206097,-0.0491649,-0.016551483,-0.0026005106,-0.041311454,-0.050041176,0.061805695,0.010245704,0.08219016,0.014270113,-0.048088737,-0.03125318,-0.048300702,-0.00086288445,0.037347876,0.09041577,0.0588828,-0.0018123505,-0.0064502764,0.014491622,0.036290906,0.080855854,-0.047900107,0.045552883,-0.09302887,0.042452186,0.03411194,-0.06461657,-0.0011421312,0.016286904,-0.024511237,0.04370106,0.004544754,0.045024388,-0.08146937,0.022316871,-0.029941248,-0.025569122,0.08227838,-0.050175462,0.102048874,0.10223188,-0.033727843,-0.052171405,0.042740714,0.01872415,-0.041882563,-0.04097292,0.009881129,0.06816395,-0.027243087,0.018878048,-0.03530453,0.007730625,0.05200655,0.0021494643,0.0021112598,0.01030493,0.0058008833,-0.09363634,-4.0395643e-34,-0.05674495,-0.056669123,0.052501597,0.068255305,-0.059819456,0.040930588,-0.023578823,0.011078642,-0.001038693,-0.06055174,-0.098856166,-0.08205141,-0.041081645,0.034164928,-0.07972415,0.038068496,-0.05720942,0.005657339,-0.03609279,0.061792187,-0.06865889,0.075371444,0.010460109,-0.12158178,0.096016504,0.018977635,-0.035579175,-0.037858628,-0.043067265,-0.0078660445,-0.052330133,0.0021160408,-0.082271665,0.057918854,0.018160459,0.039517935,0.09511974,-0.037434936,-0.10263723,-0.0041789846,-0.0047147493,0.008916416,-0.019613722,-0.013690685,0.059687067,-0.062215887,0.009765298,0.05384253,0.0567165,0.038705926,0.0426572,-0.031378895,0.10057123,-0.0040148757,-0.049955595,0.014693931,0.021109466,0.0062679215,0.116033144,0.025489366,0.037557427,-0.0035536094,-0.055734836,0.030640153,0.0120688975,0.024714066,-0.08027477,-0.055287983,0.033608735,0.07295059,-0.074937925,0.003093637,0.039474998,0.0097851865,0.0046924306,-0.107753746,-0.073813386,0.0054907035,-0.052703798,0.014971236,0.03618862,-0.06617094,-0.0044184295,0.025763366,-0.09491116,0.025306733,0.039963834,-0.033663712,-0.04046521,-0.0046464577,0.02380724,-0.014545982,-0.036602054,0.0820821,-0.004801306,-1.4195317e-33,0.083121575,-0.046587255,0.040023025,-0.052918173,-0.0645218,0.029064018,0.020888755,-0.024693102,-0.028994326,-0.055494804,0.020086478,-0.018892203,0.02201403,-0.060491633,0.04684115,0.067261264,0.0006869638,0.0019854365,-0.023897585,-0.042850096,-0.11006755,0.02441925,0.013552922,-0.026844494,-0.03521054,0.026999248,0.018810702,0.04040394,-0.05639461,-0.03708399,-0.023257827,-0.016706062,-0.050729025,-0.0076438007,0.020327777,0.009989127,-0.07000825,-0.030945871,0.010927729,-0.032250613,-0.0049016057,0.12619522,0.016589884,0.102369376,-0.030165462,0.105461985,-0.023265924,0.0030780083,-0.043922972,-0.02693502,0.027381366,-0.07452451,0.04818,0.03488804,0.057502043,0.03127138,-0.024532763,0.044848733,0.047337435,-0.02547554,-0.027264714,0.029479265,-0.03982147,0.053618863,0.07338777,0.012535361,-0.149965,0.050556038,0.057493985,0.06644415,0.03233175,-0.015237877,0.03670825,0.007609257,-0.036111265,0.08347725,-0.02393785,-0.09492738,0.036314223,-0.025876652,-0.04630799,-0.02809675,0.03301973,-0.015119132,0.004661241,-0.058635537,-0.00707868,0.04099674,0.03780494,0.035555158,0.011882379,-0.044761743,0.057379346,0.03993442,0.08351753,-2.7967934e-08,0.0752565,-0.054539125,-0.06151187,-0.03023634,-0.080377266,-0.026909567,0.009335476,0.027045384,0.046430495,0.09029846,-0.031807143,0.0072797113,0.004128872,0.05017683,-0.015479753,0.11347026,-0.076481156,0.03450632,-0.0255335,0.02165918,-0.10489385,0.020512126,-0.03175169,-0.00752757,0.015362809,-0.0669546,0.072453536,0.058287594,-0.030233381,-0.05991897,-0.06263029,0.026649667,-0.038839616,-0.019252904,0.033167847,0.097143956,-0.049086343,0.024232868,0.005728209,-0.03765335,0.05399671,-0.0955143,5.065646e-05,-0.083877526,-0.028970493,-0.0012518516,-0.02834897,0.11559367,0.009932718,-0.02765954,-0.023570053,0.029831829,0.003592565,-0.05240015,-0.11119942,-0.05851945,-0.017344926,-0.02727462,0.032902405,-0.064180255,-0.004848573,0.11570577,0.11700588,0.00037232734 +3.4.22.52,"In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2.",384,1.0,-0.005262583,-0.063762985,-0.07982668,-0.057385106,0.030808218,0.03625634,-0.011626978,0.056963194,0.12210405,0.06894216,0.072089285,-0.075231075,-0.039538693,0.09099172,0.045592215,-0.05863995,-0.113315865,-0.022708189,-0.021764139,-0.11453355,0.07357249,0.01932961,-0.01831446,0.06599177,-0.074894816,-0.0075998465,0.0031435357,-0.009251773,9.097431e-06,0.0020479225,-0.030054608,-0.037129875,0.07827721,-0.01853588,0.01741378,0.026323177,-0.058066048,-0.06298373,-0.0024021016,-0.027447147,0.065918796,0.041701097,0.003259767,0.0065128505,0.04455448,-0.0443513,0.019433934,-0.01695836,0.046317983,-0.01923363,-0.008834803,-0.03437716,-0.012501833,0.073054634,0.0074847615,0.038884506,-0.057474755,0.035428286,0.07789039,-0.029125769,0.031784028,0.010278055,0.031901255,-0.037952848,0.022860076,-0.04709057,0.0007965704,-0.07749881,-0.03837619,0.05233031,-0.04649839,-0.03267157,-0.005377453,0.06469204,0.038038347,-0.019994702,-0.01892527,-0.06325789,-0.012331699,-0.028713182,0.010168463,-0.03403353,0.027686726,0.078953594,0.035292115,0.03634085,0.066443555,0.010830171,-0.0023745056,-0.055208523,0.0599528,-0.0133248,0.07023087,-0.014320248,-0.037355334,-0.03484333,0.039790556,-0.028926114,0.02552353,-0.044804927,0.07072492,0.07502748,-0.024781935,-0.061996248,0.015516739,0.11760829,-0.012469738,0.09839013,0.01486152,0.051255316,0.030872874,-0.02825141,0.016791575,-0.012596345,-0.014706988,0.091907926,0.0097425785,-0.039588053,0.0362181,0.018522529,0.024150936,-0.02567457,-0.023156164,0.037793703,-0.020186888,0.017194334,-0.088776484,9.015772e-34,0.017798485,-0.029013017,0.027895365,0.082451314,-0.006520287,0.042166963,-0.019551942,-0.021467961,0.009887061,-0.114304595,-0.06422347,-0.010367456,-0.03888644,0.07119655,-0.013908807,0.024800828,-0.06619152,-0.05042063,0.067974955,0.026958412,0.032819603,0.026893461,-0.034301713,-0.042891636,0.083577454,0.035204835,-0.0033513408,0.024942763,-0.012796012,-0.012221388,-0.05069045,-0.06292351,-0.10916396,0.06408075,0.043493178,0.007856024,0.08236494,-0.020629287,0.013494107,0.05205298,0.0034495718,0.026277699,0.107899286,-0.044491783,0.056445893,-0.03956434,-0.05240408,0.033148043,0.052757736,0.06976862,0.027171362,-0.04325032,0.06571461,-0.026989732,-0.06992136,0.026058061,-0.022735732,-0.0147006735,0.028871138,0.020516869,0.06120247,-0.022800976,-0.009716456,0.069185205,-0.010027446,0.055772185,-0.11353556,-0.039744727,-0.015290826,0.07203717,-0.059785828,0.01636702,0.11648069,-0.025394602,0.06964629,-0.052103035,-0.044328023,0.046974298,-0.04098755,0.0683659,-0.0188011,-0.053335737,-0.023855312,0.01689072,-0.057470705,-0.033617456,0.023088783,-0.009260506,-0.10338274,0.050434433,0.007188613,-0.06310617,-0.041437406,0.07378893,-0.03368681,-2.6977665e-33,0.08283357,-0.026727756,0.10084282,-0.09704666,-0.06100087,0.060074903,0.0098879915,-0.08330223,0.05721299,-0.061752368,0.037954625,0.022642741,-0.0040668,-0.04845189,0.021413287,0.067660235,-0.062472668,0.048471384,-0.00589161,-0.009850579,-0.09669262,0.007723106,0.011962701,0.06413952,0.08117349,-0.033822317,-0.037482962,0.03751198,0.01766708,-0.03065749,-0.12119868,-0.024613911,-0.07269763,-0.008622277,-0.08746771,-0.048195917,-0.029790396,-0.021592911,-0.0046467157,0.019616798,-0.016653897,0.05415015,-0.035075758,0.124884315,0.015493212,0.07299872,0.044399317,0.024444073,-0.08488782,0.021695659,0.0055612815,-0.060165588,-0.008541256,0.039847802,0.06425881,0.07819612,0.008008053,0.096622534,0.0067122984,0.027986057,0.008324115,-0.017441941,-0.030428555,-0.0148876915,0.0027537884,0.0021596176,-0.12677132,0.051295377,0.106653094,0.030857299,0.07279644,-0.036534563,0.037877273,-0.025906898,-0.07565315,0.028680498,-0.07112358,-0.08638242,0.052631304,-0.034439288,-0.016807083,0.019780776,-0.005731504,-0.020863578,-0.023185428,-0.01985377,0.009069624,0.04949006,0.010860685,0.041774575,-0.0015023731,-0.032077875,0.031499367,0.040825635,0.01833201,-3.8567777e-08,0.038638636,0.019379651,-0.08620799,-0.08534025,-0.058621608,-0.0009321842,0.00893952,0.0073366784,0.041001417,0.0478072,-0.0041265143,-0.013301311,-0.03299671,0.06749648,-0.009616824,0.12189378,-0.034467604,0.02098134,-0.011451044,0.03247472,-0.09433868,-0.014544001,-0.12822194,0.06923184,-0.037814338,-0.03904521,0.002482132,0.07502569,-0.04688216,0.022076823,-0.01988583,-0.023886073,-0.057775762,-0.06562607,0.003189834,0.042662356,-0.035036918,-0.06499223,-0.03067407,-0.026231172,0.0508927,-0.080314875,-0.053494968,-0.041379776,0.024162691,0.0030600643,0.011821444,0.0064248373,0.009150656,-0.03599822,0.02834628,-0.02884812,-0.052449357,-0.10363266,-0.15963344,0.02475193,-0.012054618,-0.022659821,0.011557883,-0.08601074,0.05326863,0.07063794,0.14639316,-0.027885282 +3.4.22.53,"Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1.",384,1.0,-0.00018197844,-0.0969403,-0.06703767,-0.07097387,0.018264648,0.034512915,-0.0068383543,0.065943815,0.11458822,0.046642363,0.074091144,-0.08184992,-0.029129652,0.10472879,0.042559747,-0.06410361,-0.11386746,-0.027435234,-0.015068456,-0.088593625,0.06893519,0.02801007,-0.009847022,0.082903534,-0.08098991,-0.024531618,0.02071631,-0.010141869,0.009050094,-0.01573693,-0.024899945,-0.039913602,0.06648443,-0.0033539897,0.05507856,0.037147254,-0.08458616,-0.034126677,-0.0044859755,-0.01728506,0.06607656,0.04655199,0.021563342,-0.011216631,0.046642534,-0.06824636,0.0049799504,0.0026874184,0.037836075,-0.046456087,0.001766264,-0.04355864,-0.01670807,0.09178574,0.018726917,0.005126774,-0.07250856,0.054292336,0.0805638,-0.026621068,0.03669528,0.034110013,0.013760792,-0.06163821,0.0061164293,-0.016810142,-0.005002179,-0.07026534,-0.020545237,0.058595322,-0.05276034,-0.038405526,-0.028079761,0.082924105,-0.0002546954,0.0007435243,-0.004393353,-0.04415698,-0.029289734,-0.03448513,-0.032148253,-0.033093803,0.031595252,0.06695854,0.04289018,0.04596133,0.057149287,0.009079024,0.017115198,-0.05023095,0.053998,-0.029068006,0.0814884,-0.052755307,-0.023643034,-0.054511845,0.05641743,-0.035484213,0.031884737,-0.033164863,0.07139501,0.056932002,-0.012940418,-0.052817285,0.025565218,0.12192278,-0.0036369395,0.06491343,0.018592848,0.049020074,0.0021032111,-0.028829614,-0.0040554865,-0.031921677,-0.027916498,0.043969497,0.014979944,-0.05442347,0.017953716,0.02912212,0.041075002,-0.038285196,-0.0020311037,0.02381887,-0.030037958,0.024714682,-0.07528924,1.2190214e-33,0.005560179,-0.048353173,0.024775267,0.068542026,0.012802802,0.03249591,-0.027242228,0.004065782,0.015064517,-0.09698611,-0.052928925,0.009654752,-0.04639888,0.09174948,-0.035332527,0.026855491,-0.06890872,-0.0343605,0.056717254,0.024633475,0.032242235,0.062428467,-0.02779733,-0.023681084,0.076515034,0.02657113,0.0028820962,0.028249282,-0.018758247,-0.0065765698,-0.0498564,-0.060673572,-0.11292866,0.04657856,0.026561933,0.021532817,0.07559094,-0.025750583,0.03385709,0.042443898,0.0078809615,0.021549374,0.09181141,-0.054173823,0.08210729,-0.03374963,-0.046604708,0.039057996,0.0155719835,0.06746078,0.010695789,-0.03736152,0.051762365,-0.031247206,-0.060519367,0.03197281,-0.00804315,0.013898593,0.03308077,0.03834458,0.0484468,-0.008298974,-0.015219513,0.05407321,-0.020854736,0.04036424,-0.12172596,-0.040240515,-0.016689982,0.08145422,-0.058430325,0.021001318,0.08489069,-0.031641714,0.06097025,-0.06454176,-0.056472145,0.047233995,-0.06215665,0.06936138,-0.023289176,-0.06727634,0.004644203,0.008232551,-0.07518496,-0.024870101,0.017957496,-0.0031668828,-0.107056566,0.032973792,0.005848324,-0.053280868,-0.030321829,0.08078781,-0.023638982,-3.127421e-33,0.060874693,-0.0042725652,0.085453376,-0.115899645,-0.04426863,0.0764244,0.015777597,-0.087448694,0.041287236,-0.058387663,0.028432727,0.02756981,-0.016514814,-0.06457349,-0.0148660485,0.052413058,-0.050919186,0.06394915,-0.00046761482,0.006602291,-0.116325945,0.0071139336,0.0049966397,0.0475481,0.08721611,-0.013661376,-0.06537429,0.067565784,0.03196436,-0.044259135,-0.12693506,0.0043246746,-0.028809102,-0.021636367,-0.08622969,-0.038696233,-0.021797337,-0.016714832,-0.0035712067,0.017574271,-0.014713712,0.056736413,-0.004442814,0.117270604,0.008165095,0.06799177,0.027257614,0.00450602,-0.040272873,0.02766369,0.0046124454,-0.057960834,-0.028240792,0.05307021,0.074126326,0.059444375,0.024096835,0.09725553,-0.0130068455,0.03067115,0.0014439211,-0.030215366,-0.017822796,-0.006184931,0.02298321,-0.026334744,-0.14135106,0.02886698,0.10516806,0.043753155,0.074261315,-0.03200333,0.04315298,-0.046108115,-0.07380815,0.028719546,-0.064607605,-0.0866434,0.053898636,-0.046899483,0.0022477375,0.017376577,0.0057938164,-0.013381383,-0.016242383,-0.014365652,-0.0075639803,0.035599142,0.01113623,0.054728616,0.02286479,-0.028911421,0.032797452,0.061664574,0.028550735,-4.010871e-08,0.05632812,0.012932483,-0.0625191,-0.071118556,-0.051776998,-0.024966126,-0.011530625,0.010411457,0.03340021,0.049558047,-0.030897727,0.015617236,-0.024051694,0.061105374,0.01167939,0.093385644,-0.050188914,0.0138549935,-0.01770146,0.040311493,-0.10094574,-0.008919452,-0.119187966,0.06852157,-0.050739687,-0.03533287,0.00045574925,0.073967725,-0.038312394,0.028178953,-0.010763217,-0.0041801115,-0.059965298,-0.08031231,0.032641027,0.046904597,-0.043683372,-0.04533546,-0.045584608,-0.00820418,0.049728177,-0.10061049,-0.07190951,-0.04845305,0.051544335,0.017332872,0.0045792786,-0.011519581,0.00706047,-0.011895647,0.036671504,-0.004799603,-0.06913243,-0.11096736,-0.15690964,0.03732174,-0.009285887,-0.026780348,0.026208866,-0.10592888,0.07774488,0.056299407,0.13947982,-0.004196822 +3.4.23.1,"The predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis. Human pepsin A occurs in five molecular forms. Pig pepsin D [1,2] is unphosphorylated pepsin A. Type example of peptidase family A1.",384,1.0,0.07385389,-0.095069915,-0.08763273,-0.025045931,0.021403456,0.09992303,0.07237697,0.038504496,0.060875725,0.02859322,0.077519156,-0.047783144,-0.1260624,0.05761719,-0.03287365,-0.0647563,-0.039279614,-0.080156036,-0.047845088,-0.09318582,0.09577004,-0.004114121,0.049223486,0.02604642,-0.049027383,-0.035610788,0.08843195,-0.07311567,0.023822453,-0.06056215,0.039593574,-0.121400766,0.049873404,-0.06722635,0.092953846,0.0070629567,-0.00604548,0.011050119,0.06668918,-0.02509247,0.07027716,-0.042561673,-0.02893115,0.014735822,0.023188347,0.054475028,-0.014359446,0.09139639,0.021743972,0.02756843,-0.027012903,-0.054393016,-0.056781538,-0.08232093,0.028156132,0.032740228,-0.015982386,-0.035501488,0.02892259,-0.028915681,0.066688,-0.0014950482,-0.020638784,-0.034500726,0.03564231,-0.08346362,0.08300047,-0.022488141,0.024815505,-0.02181084,-0.025528202,-0.033910435,-0.022074312,0.023019684,-0.05515354,0.08138542,-0.019128336,-0.049806453,-0.08066351,-0.022088338,0.075203456,-0.015736852,0.048330747,0.040780127,-0.015907558,0.033570275,-0.054688692,0.079903886,-0.048878092,0.009177768,-0.064053245,-0.098483354,0.07218516,-0.06808334,0.037650775,-0.017154567,0.015028218,-0.11336045,0.07892895,-0.02356955,-0.02038005,-0.019874623,0.051833123,-0.06808564,-0.0069401967,0.058796473,-0.09890293,0.08389441,0.116479635,-0.0004023604,0.004287271,0.019867912,0.03324536,-0.022096131,-0.0042883633,0.028054787,-0.043021828,-0.036664348,-0.039001558,0.07105052,-0.0074551334,0.059883103,0.022101663,0.08515534,-0.030123208,0.052485295,-0.068961255,4.0521252e-33,0.011391379,-0.042116944,0.047040395,-0.0023075503,0.032975253,0.10917242,-0.010726211,0.03855198,0.05281377,-0.020926038,-0.092621475,-0.100131504,0.025918411,0.01686507,-0.0761603,0.0038956155,-0.049077608,0.021031255,0.002917642,-0.015340166,-0.06859155,0.09089568,-0.0046876306,-0.053586278,0.0029782983,0.01248766,-0.07641284,0.0036345655,0.06897534,-0.027403628,0.036237765,-0.05947015,-0.04100524,0.04549612,0.058950767,-0.014887346,0.055208977,-0.060923092,0.041621253,0.025988523,0.013180472,-0.027812155,0.012472681,-0.017293138,0.021705791,-0.07153479,-0.035769235,0.02291473,0.005097791,-0.01761561,0.009213252,-0.009410831,0.10788164,-0.076246426,-0.057985745,-0.012714771,-0.00297192,0.041181356,0.009199594,0.03194876,0.025883993,0.132327,-0.08076662,-0.06094265,-0.049213838,0.008953771,-0.098251946,-0.041758437,0.007276452,0.05041786,-0.019129628,0.018833624,0.037651293,-0.014479913,0.049099892,-0.01868044,-0.0942496,0.069799006,0.012200396,-0.012417358,-0.008853237,0.065620996,0.024860108,0.0036356184,-0.03141706,0.05778831,-0.02981915,-0.10885655,0.022422517,0.08573104,-0.09757883,-0.052309446,-0.06462448,0.03174722,0.027024057,-4.201364e-33,-0.029085942,-0.03372376,-0.045835078,-0.023383562,-0.0134973265,0.06458278,0.031207053,-0.021764444,-0.050692048,-0.087857716,0.042051792,-0.024331916,0.05444524,-0.079308785,0.011442118,0.048904743,0.018108157,0.079083644,0.073739864,-0.039814435,-0.07416444,0.00061688514,0.022068089,0.012179314,0.10997432,0.027503774,-0.01506856,0.06247201,0.07212126,0.023859609,0.047793522,-0.015986776,0.018254269,-0.052326363,-0.04028841,-0.026579864,-0.097738415,0.0074468935,0.029502442,0.033657663,-0.05528105,0.0076303263,0.07552134,0.09417291,0.039716374,0.023806108,-0.051180225,-0.04552731,-0.005024015,-0.018095136,-0.018464277,-0.071482204,-0.042271346,0.025525767,0.038032867,0.05842331,0.047782674,0.045214836,0.0047478285,-0.07993981,-0.015886484,-0.023732092,0.09554467,0.011165669,0.09797723,-0.059128333,-0.0792811,0.039858237,0.0317647,-0.01724894,0.06647029,0.00073852186,-0.0007721991,0.009753814,-0.02482393,0.04749726,-0.046283383,-0.028875235,0.06531985,-0.06735286,-0.06629224,0.03809303,-0.014314811,-0.023065737,0.038802907,-0.021672936,0.027437732,0.0792688,0.019960621,0.11425188,-0.016841728,-0.020570753,0.014936009,0.02319242,0.05174058,-3.3124266e-08,0.06518014,-0.05793018,0.03056131,-0.0019118844,-0.008710113,0.0034832803,0.06479306,0.0018766051,0.020440742,-0.059108946,-0.06376837,-9.3643815e-05,0.03598236,0.044623673,-0.009238222,0.061027203,0.0043875943,0.030230766,-0.015521755,-0.0061077694,-0.116325475,0.02231241,-0.093713485,-0.037847176,-0.028652886,-0.047693856,0.0074399277,-0.002827354,-0.012260395,-0.005412294,-0.01879994,-0.02562497,-0.0474934,-0.04995693,0.019603312,0.07687728,0.011772533,0.015606761,-0.035069507,-0.0045839767,0.0003939586,-0.021822417,-0.033366162,0.027466416,0.044370778,-0.050954774,0.035078205,0.04417454,-0.05213878,0.013588379,-0.019080793,-0.02537523,-0.020332893,-0.044025358,-0.040774297,-0.042914256,-0.012833289,-0.051080957,0.024242401,-0.02609078,0.04292751,0.09644975,0.15971664,0.0038711121 +3.4.23.2,Formed from pig pepsinogen B. In peptidase family A1 (pepsin A family),384,0.99999994,-0.0046015102,-0.043612152,-0.07663625,-0.01927773,0.014521606,0.06208496,-0.0019574957,-0.0039535477,0.02768941,0.018892875,0.10286033,-0.053903677,-0.009573448,-0.003913617,-0.043925762,-0.013999966,-0.022876931,-0.05238728,-0.052681774,-0.09508918,0.06223211,-0.09560349,0.01562706,0.05368055,-0.07160087,0.022873154,0.0958614,-0.022947954,0.04296622,-0.08037733,-0.0194554,-0.04350324,0.11924518,-0.111095265,0.051899213,-0.004773436,0.031622402,0.0056798304,0.13565202,-0.02180628,0.044245403,-0.033096027,0.036872808,-0.040646087,0.021437876,0.028829863,0.0075422022,0.1281521,0.042894937,-0.016107606,-0.03869927,-0.034058623,-0.04874277,-0.10148325,0.04963531,0.012912383,-0.072852045,-0.05180645,0.02512159,0.0013652877,0.034939457,0.018452268,-0.02241971,-0.028662521,-0.019476576,-0.01308338,0.09965514,-0.024904253,0.04068368,-0.023640683,0.01256076,-0.021532752,0.027864296,-0.0037866132,-0.09716505,0.047438085,0.0696909,-0.03750758,-0.061200082,-0.013757388,-0.011112265,0.0069899806,0.04088854,0.044994038,-0.042563725,-0.005547868,-0.026182402,0.027771512,-0.06140884,-0.011544717,0.01321366,-0.07614284,0.10489582,-0.021250695,6.456985e-05,0.0014013916,0.04123565,-0.06448061,0.060113724,-0.0054189824,0.00022576675,0.019613681,-0.00062794035,-0.068571,-0.031620905,0.02975493,-0.1159028,0.10501813,0.1093602,0.11004537,-0.016459437,0.0154794315,-0.025522064,-0.02134058,-0.06026324,0.054246366,-0.017619312,-0.02839191,-0.0065126475,0.048652917,0.019565362,0.070963226,-0.00019030922,0.061765626,-0.035373434,0.023537982,-0.068704605,-7.5408325e-34,-0.013537746,-0.031874537,0.022074634,0.04202135,0.045878097,0.049510464,-0.054296363,0.04380118,0.031776957,-0.052104477,-0.089213304,-0.09277521,0.036539085,-0.03461732,-0.08317154,0.01846229,-0.070599586,-0.039257836,-0.033150513,0.051188562,-0.1630065,0.080610916,-0.02775169,-0.022851815,0.004033141,0.018099917,0.0031031633,-0.006464467,0.0341862,-0.027557444,0.014087362,-0.037541546,-0.07899999,-0.01824413,0.027785644,-0.025780912,0.0108643565,-0.05495266,0.047667958,0.077628285,0.058026325,-0.034827072,0.05375772,-0.0066656503,0.029486932,-0.019963786,-0.03791662,-0.023764975,0.062866285,-0.00020607981,0.041973867,0.0033703765,0.051242974,-0.004912667,-0.08544423,0.0070606517,4.5114443e-06,-0.01315918,0.015575144,0.041584782,0.07900062,0.10967235,-0.06979534,0.017085992,-0.070177585,0.031848885,-0.10675584,0.028524838,0.025365131,0.02456172,0.02164315,-0.024057653,0.058834016,-0.058259293,-0.0034335754,-0.010261133,-0.04855609,0.0525856,0.0071505685,0.00048785994,-0.00027864272,0.090974726,0.1016306,-0.009442486,-0.049033154,0.03163752,-0.033602715,-0.039837033,0.015446499,0.046176605,-0.082339525,-0.06573173,-0.05175195,-0.010480969,-0.00405469,-1.2358436e-33,0.036765408,-0.03411493,0.0565299,-0.05598878,-0.052637156,0.018313264,0.027224261,-0.023676462,0.025858723,-0.011217026,0.0009195206,-0.011648822,0.022626657,-0.06422599,0.01073996,0.12048406,0.024640108,0.055657934,-0.051713627,-0.05277957,-0.09173046,0.04128661,-0.0055386983,0.017595222,0.05790208,0.0036453507,0.02374257,0.050686136,0.08704929,0.012946071,-0.0012218762,-0.075170524,-0.023309669,-0.0002798009,0.011184314,-0.034506753,-0.058807757,-0.0008823634,-0.040526707,-0.0062661218,-0.09249437,0.051650368,0.00866918,0.099694796,0.048567355,0.046895754,0.0016695177,-0.04680978,-0.029740453,0.012542789,0.011323242,-0.07064621,0.015380208,0.04519173,0.021484904,-0.00016589781,0.038474794,0.09874038,0.010828729,-0.039982874,-0.000980652,0.0045489715,0.034160893,0.00017800907,0.06885746,-0.03208351,-0.096258365,-0.0048641344,0.10752009,0.009265339,0.04632601,0.062796615,0.007636906,-0.0052068112,-0.01802918,0.09986417,-0.075024575,-0.04672914,-0.03048475,-0.044389002,-0.061481565,0.0093915025,0.016582252,0.04173946,-0.048198674,-0.048554014,0.10914386,0.11986294,0.049593255,0.06811065,0.06742466,-0.024441302,-0.0057010404,0.051121213,0.052162517,-2.1385295e-08,0.068129525,-0.09837179,-0.0222544,0.015045469,-0.034854133,0.0018505349,0.01780203,-0.05267177,0.027345167,-0.03685603,-0.08658071,0.030613057,-0.03683086,0.041247647,-0.06247404,0.029543003,-0.033758722,0.02208971,0.019419016,0.08539303,-0.11453708,0.030810693,-0.05877375,0.0038768565,-0.026679909,-0.05918623,0.015875112,-0.047675375,0.00060448266,-0.00606584,-0.04073614,-0.01688818,-0.032051563,-0.09066995,0.04625613,0.01917725,0.040315237,-0.011109852,-0.016001184,-0.012939453,0.06998023,-0.06649494,-0.035026863,-0.018965075,0.03266928,-0.07905338,-0.076373026,0.06425063,-0.033949953,0.011289244,-0.016766133,0.08148153,-0.057218056,-0.048473302,-0.06766297,-0.052477803,-0.039817825,-0.059455737,0.034778025,-0.011262966,0.065784566,0.054281533,0.15745075,0.020441864 +3.4.23.3,"Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family).",384,0.99999994,-0.026318561,0.001904803,-0.17164618,0.007084672,0.029960142,0.043184016,0.06467186,0.053050105,0.06056119,0.02161225,0.024101561,-0.036205105,-0.09997285,0.037562065,-0.023555662,-0.09192325,0.028642781,-0.115134105,-0.010718564,-0.04656492,0.06919807,0.015925359,0.072842665,0.004673566,-0.038157374,-0.06427117,0.060154818,0.045274764,0.019958941,-0.029782701,0.022990512,-0.061143603,0.029680489,-0.043525085,0.039878793,-0.053595733,0.0018473752,-0.0108459685,0.06273646,0.0213875,0.14880702,-0.03905895,-0.0538055,-0.052795194,-0.0056692543,0.001440194,0.03078898,0.08103417,0.030857861,0.04377483,-0.0729928,-0.12780514,-0.006487658,0.061846003,0.037271056,0.00089267327,-0.049018487,-0.06911515,-0.012895409,-0.0037705435,-0.04747401,0.071681105,-0.0060286266,0.03438297,-0.022295697,-0.09347158,0.011070541,0.025514612,0.0029133258,-0.06747119,0.05525002,0.0055401884,0.020755328,0.061289888,-0.039327208,0.072708085,0.017332643,-0.073112324,-0.08254651,-0.05988193,0.016221622,-0.01028659,0.036996666,0.081942484,-0.05247093,0.00837807,0.037119314,0.035095975,-0.100447826,-0.106240086,-0.016761584,-0.08391515,0.070508294,-0.0361867,-0.0019814412,-0.0126005355,-0.021199392,-0.11072122,0.059152026,-0.013163153,-0.062519565,-0.01581014,0.08334341,-0.07622982,-0.060982093,0.10770466,-0.08946796,0.0900203,0.09829781,0.059273686,0.0032205188,0.0018514288,0.022312112,0.010882724,-0.027215397,0.03546405,-0.051535446,-0.0014938194,-0.0025344798,0.042081818,-0.015102111,0.0073628547,0.0051144594,0.04897666,0.014394592,0.03614289,-0.024911739,1.1543094e-33,-0.0031669964,-0.087290816,0.041028067,-0.0008575202,-0.0012885893,0.1441964,0.022959722,-0.061088406,0.06373647,-0.009129353,-0.060446832,-0.0576539,0.012881789,0.01929771,-0.076910496,-0.024245482,-0.043073244,-0.038802046,0.01759688,0.065134734,-0.010256711,0.13384707,0.010241768,-0.11484974,0.042688776,0.035920117,-0.04058868,-0.039243355,0.029431198,-0.0064420043,0.043743342,-0.011391293,-0.044112615,0.052901875,0.044167284,0.046841368,0.016145365,-0.09087306,-0.03264711,0.053642783,0.05021661,-0.09357946,0.0027175383,-0.017888822,0.0066758255,-0.06475466,-0.09242075,-0.032119635,0.04582767,-0.013776543,0.036982745,0.01555893,0.08065438,-0.03377677,-0.084742956,-0.018631186,0.011063637,0.026255123,0.03909483,-0.0014066267,0.02830839,0.04179098,-0.065739326,0.055335544,-0.066344626,0.030290151,-0.07110062,-0.05654179,-0.006758761,0.006462431,-0.08583027,0.034599315,0.048360623,-0.061171476,-0.0074093216,-0.0628958,-0.05117996,0.0511109,0.01728508,-0.017797425,-0.022232821,-0.027956465,0.02863619,0.080405824,-0.051962007,0.061158147,-0.033534322,0.04167774,0.05071629,0.019180065,-0.0306216,0.025274795,-0.048241142,-0.006978468,0.019321099,-3.3642472e-33,-0.043610148,-0.036389202,0.044834577,0.011299822,0.043025434,0.053916663,0.047065847,-0.011974692,-0.09903697,-0.045373343,0.015615376,0.011166886,0.014072456,-0.10745406,0.03515229,0.058568582,-0.0013007639,0.086440235,0.018718546,-0.04758462,-0.059358757,0.02876294,0.03903965,-0.0033435174,0.07478892,-0.03181114,0.059413057,0.03776647,0.000158252,0.030006455,-0.0111466795,0.093045376,-0.09310688,-0.075104564,-0.03524213,-0.05667392,-0.04707536,-0.017558785,0.009070189,-0.07261097,-0.0891421,0.043950923,0.013348818,0.08036391,0.036510672,0.106719285,0.035325013,-0.031809524,0.029032363,0.04737889,-0.04681669,-0.073701344,-0.034055598,-0.017103652,0.06597477,-0.008959475,-0.004899013,0.015548553,0.066512026,-0.039659545,0.00081332045,-0.013085624,0.063965164,0.044537015,0.062020835,-0.010557795,0.008472929,0.023463443,0.03554999,0.05828523,0.13595122,0.016642608,0.014359544,0.003244989,-0.010628123,0.09342721,-0.063750744,-0.06505742,-0.016684538,-0.00045977486,0.0047988845,-0.046591997,-0.022748359,0.0012627296,0.025927918,-0.033972293,0.0210851,0.022252036,-0.024837974,0.019899279,-0.027388027,0.01812365,0.016690582,-0.0721726,0.06255817,-3.447132e-08,0.08029252,-0.07721397,-0.009101503,0.0024953547,-0.006347426,-0.11569463,0.013932273,0.0021261394,0.070446655,-0.018127026,-0.052302185,0.029109044,0.06436498,-0.005359475,-0.0074352487,0.059917457,-0.0068288506,0.033994153,-0.020151518,0.015746584,-0.039388362,0.004984056,-0.067093894,0.018240832,-0.05484575,-0.012958402,0.010238938,0.008552723,0.0029312738,-0.055395506,-0.019605765,0.016068196,0.015153687,-0.006443953,0.012040341,0.05696553,0.020530716,0.059055317,-0.015076771,-0.06531085,0.01455478,-0.107095346,0.055007923,-0.05782095,-0.038383648,-0.01818122,-0.00091485825,0.06413155,-0.018792037,-0.03927772,-0.05530217,0.0017457665,-0.010348381,-0.04343293,-0.019096617,-0.018484222,-0.02500336,-0.055132736,0.044861063,-0.004342626,0.038211744,0.033820294,0.17701831,-0.0022479037 +3.4.23.4,"Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family)",384,0.99999994,0.02171245,-0.07705329,-0.13067919,-0.029257763,0.07511906,0.045810208,0.05277256,0.11649605,0.029699966,0.02135699,0.014311894,-0.032987334,-0.10227763,0.105744824,-0.025618663,-0.0077557056,-0.043702222,-0.095792025,0.057743732,-0.1322878,0.025875041,-0.032364834,0.035682347,0.06541388,-0.013139338,-0.048876423,0.10195499,0.009145918,0.049208757,0.032543328,-0.07670281,-0.15386224,0.0818848,-0.033772524,0.0756538,0.0445926,0.029079631,-0.019161789,0.022474764,0.0049470677,0.074143864,-0.0040764017,-0.051050838,-0.09462896,-0.0147153195,-0.044559963,0.010074907,0.078676686,0.03109821,0.069078,-0.03388944,-0.10146088,-0.023279317,0.0065377867,0.014094113,-0.024443222,-0.046188947,-0.07560525,0.045065675,-0.017616335,-0.04065849,0.011430167,0.006327938,-0.009245646,0.010204512,-0.06729509,0.04519237,0.051019706,-0.0068884906,-0.025005873,-0.01360103,-0.0055906386,0.040612236,0.08046724,-0.053690158,0.062267322,0.034992415,-0.04778177,-0.031614836,-0.026407428,0.048458744,0.0041664434,0.0202525,0.03631186,-0.050703924,0.009010983,0.0058935587,0.016844328,-0.015669912,-0.1307521,0.02862076,-0.021486763,0.014280557,0.011231013,-0.017636001,-0.0013507998,-0.100102395,-0.059231706,0.09119385,-0.016397707,-0.018526958,-0.021743026,0.07293026,-0.03479217,-0.016811244,0.115924515,-0.056236863,0.060435325,0.09724734,0.019392457,-0.036914386,0.023460783,0.068897806,0.06684673,-0.012552123,0.028927242,-0.060519055,-0.018604595,-0.012637515,0.06369727,-0.015136282,0.07940062,0.0071779103,0.033889707,-0.011661586,0.05353221,-0.040942412,4.1544847e-33,-0.006365304,-0.04753477,0.09542198,0.026887136,0.025406046,0.09191139,-0.017914247,-0.02024083,0.020139975,-0.014032091,-0.03351366,-0.067688264,0.045017336,-0.022652429,-0.039798778,-0.00220141,-0.013755935,-0.075707465,0.034154877,0.08467491,-0.057908185,0.038152006,-0.040994585,-0.05148652,0.045661364,0.113192536,-0.018591572,0.01798146,-0.012512897,-0.022741165,-0.012259093,-0.06951225,-0.049878284,0.06744011,-0.020266367,-0.08124038,0.07550208,-0.055652387,-0.008690435,0.05202091,-0.03625769,-0.07476406,-0.016845783,-0.01466976,0.021785976,-0.061228782,-0.09002005,0.026551072,0.01170785,-0.020770175,0.070982754,-0.086639784,0.03155457,-0.07811031,-0.05618185,0.03954613,-0.0039005221,0.036168344,0.0962296,0.043442074,0.06572814,0.055386584,-0.03014252,0.010467542,0.0077809347,-0.025781352,-0.07635114,-0.014493848,0.0055232556,0.045202646,-0.043110546,0.04317623,-0.013674801,-0.04343735,0.015442238,-0.084329955,0.009988941,0.056814354,-0.019841246,0.008216579,0.007312306,0.00046232154,0.08419293,0.08379575,-0.07170746,-0.0007743584,-0.047107283,-0.02280555,-0.01049598,0.07190929,-0.064063564,-0.014798118,-0.088826865,0.061293323,-0.019571183,-5.339722e-33,0.070655495,-0.0030140327,0.026640879,-0.07914341,-0.07197038,0.041939177,0.035809085,0.013791342,0.0076201227,-0.04086142,0.015940802,-0.013222003,0.04257611,-0.049405057,0.06820592,0.09189312,-0.025252037,0.035098307,-0.003778937,-0.025663586,-0.052465774,0.069688484,0.002600956,0.006844725,0.097583376,0.0028861244,0.054970127,0.07196248,-0.0020804808,0.010865681,-0.013246796,-0.0038928313,-0.015675452,-0.08120878,-0.030994829,-0.050602484,-0.041187894,-0.034347687,0.03234159,-0.054805644,-0.09554977,0.053052384,0.045656368,0.061839435,-0.06469133,0.09051981,0.026112521,-0.07910468,-0.031746447,-0.02460459,-0.06273065,-0.090003796,-0.023608832,0.019842621,-0.005166168,0.005684979,-0.0031737848,0.006242789,0.095965706,-0.015360418,0.031640653,-0.018755341,0.0058812005,0.026374353,0.041184314,-0.048606683,-0.07441484,-0.051924966,0.08726787,0.028884714,0.09877688,0.04937264,-0.015231079,0.012218013,-0.047404997,0.104741216,-0.07057544,-0.039854158,-0.004829184,-0.03596009,-0.054169208,0.009920333,-0.002680854,-0.02041998,0.001699824,-0.061241534,-0.015336686,0.0821111,0.024714917,0.04094948,-0.019140076,-0.021680849,-0.00029606145,0.013037941,0.016193157,-3.388192e-08,0.04511248,-0.04834954,-0.017117804,-0.018087242,-0.015674835,-0.03958352,-0.026304057,-0.016460074,0.04818326,-0.012041413,-0.07475455,-0.028560879,0.013157013,0.031527754,-0.06945244,0.055157017,-0.005624422,0.040738463,0.0019332422,0.05724111,-0.083472714,0.026396343,-0.038555104,0.034785118,0.0146416,-0.06770661,0.042285938,0.053895663,-0.025339618,-0.012982383,-0.08720489,0.05498172,0.0067687347,-0.04400638,0.05949385,0.081105225,-0.015355934,0.049006928,-0.037275475,-0.022965869,0.07843724,-0.0749563,0.01687882,-0.083980456,-0.04542317,-0.035143204,0.00684079,0.0075765876,0.054485966,-0.064219855,-0.022429531,-0.04971783,-0.05105016,0.0047742384,0.017477851,-0.007347855,-0.032403715,-0.09550244,0.026926532,-0.0029788963,0.008713795,0.026621412,0.18280484,0.00038715394 +3.4.23.5,"Occurs intracellularly, in lysosomes. A zymogen form is known [4]. In peptidase family A1 (pepsin A family).",384,1.0,-0.038716618,-0.07748881,-0.066695906,-0.019702287,0.031332426,0.044163126,-0.023036739,0.071299516,0.070116326,0.0058965925,0.028376957,0.009177339,0.030721841,0.08561429,0.03287206,0.027606048,-0.09664812,-0.09505587,-0.040259637,-0.05488333,0.09229555,0.031239761,0.04814961,0.00805198,-0.038840286,-0.09240888,0.07544856,0.0445295,0.07745683,-0.05462544,-0.00018941895,0.0073990677,0.07163786,-0.030677583,0.045690253,-0.026511468,-0.038898457,0.008802621,0.10778883,-0.047703303,0.11656458,-0.010302471,-0.047593664,-0.055359107,0.009952242,0.019226922,0.02011772,0.06902644,-0.0042227777,0.046912562,-0.0625661,-0.10973979,-0.040619113,0.049892884,-0.05989116,0.039514933,-0.106939115,-0.0074803997,0.08988218,0.025340917,0.0067381035,0.07840007,0.013381195,0.010114176,0.014649504,-0.055959173,0.022179233,0.037725095,-0.013703318,0.02227767,0.06341335,-0.0383109,-0.041618507,0.009434069,-0.021686077,0.034447785,0.077437155,-0.055711944,-0.07033997,0.01793232,0.015287876,0.03803436,0.085576095,0.07564836,-0.021129109,-0.0155657735,0.007740873,0.0272764,-0.03612987,-0.025871115,-0.02608924,-0.083718024,0.069371134,0.04723717,-0.078783564,-0.04754131,0.05856484,-0.08312137,0.112532385,-0.0009235449,0.043792535,-0.017294202,0.022445554,0.0078562265,0.05110644,0.06611612,-0.011827373,0.04131098,0.006366403,0.011346906,-5.0103863e-05,-0.019919543,0.06266301,-0.024034688,-0.031095186,0.002578233,0.005721494,-0.010040881,-0.022137273,0.021066085,0.018887604,-0.0029957423,-0.024820363,0.0347518,-0.037508596,0.04482543,-0.11440576,-2.7894688e-33,-0.009544495,-0.022852214,0.010392236,0.05526938,-0.053061184,0.04122764,0.032572225,0.0014435838,-0.014091781,-0.044173207,-0.07052567,-0.056142677,0.04170496,0.017057354,-0.11250663,0.015191724,-0.06033216,-0.0027765462,-0.035137724,0.084765285,-0.024381395,0.009894819,-0.032984648,-0.10407977,0.048561063,0.0709591,-0.0068861055,-0.059100978,0.06641293,-0.007902413,0.01266145,-0.04967913,-0.13854189,0.07037,0.05567377,0.07254677,0.058841996,-0.028928667,0.010372191,-0.024530813,-0.017106168,-0.02775332,-0.04680218,-0.0514768,0.039915532,0.0196065,-0.06170592,-0.012200641,-0.027412191,-0.05768047,0.018560989,-0.020681659,0.07897947,-0.008921071,-0.09259669,-0.004097721,-0.03210793,-0.0074677714,0.033815976,0.020686543,0.06502484,0.0073547396,-0.07277826,0.14847814,-0.0064165317,0.03382855,-0.11100159,-0.092767954,-0.033317603,0.010179639,-0.03379706,0.009100283,0.07693686,-0.048052166,0.0144166425,-0.062333565,-0.061144184,-0.01732198,0.010038695,0.057177734,-0.015740909,-0.03949052,-0.027618349,-0.015666373,-0.00059950224,-0.019773643,-0.0051450003,-0.039397508,-0.05746404,0.05408688,-0.034627818,-0.050332416,-0.040918265,0.042581044,-0.050907735,-9.283046e-34,0.032040495,-0.019498063,0.08345004,-0.09018137,-0.02932013,0.04605693,0.051810384,0.024949681,0.041798163,-0.0069260974,-0.028223677,0.018895425,-0.0090216175,-0.03692171,0.002486125,0.017611623,-0.024927083,0.04562812,0.020091988,-0.010862877,-0.08701678,0.0070270994,-0.0027447236,0.028252805,0.011098246,-0.0038636655,0.005469337,0.08907439,0.029347409,0.0072370027,-0.07794785,0.01176562,-0.012824088,-0.043888688,-0.017685063,0.01903433,-0.025516162,-0.089201726,-0.012188989,-0.06033882,-0.05438846,0.018600697,0.023836378,0.13559262,0.07293904,0.046118177,-0.072818056,-0.010046721,0.0118544465,0.05167596,-0.025014848,-0.083542496,-0.015796836,0.04539563,0.02787836,0.055216804,-0.014786249,0.07113792,0.013419505,-0.024315145,-0.03787376,0.0037609253,-0.055894338,0.014641642,0.060439877,-0.025063472,-0.053592544,0.045910943,0.058564313,0.013752959,0.102320015,0.06879032,-0.039425176,-0.042618312,-0.022453927,0.07550647,-0.114827484,-0.096511215,-0.032452878,-0.0703577,-0.041616566,0.019868467,0.055469546,0.054186918,0.00077091384,-0.0956456,0.049345177,0.058433276,0.002959906,0.00075524335,0.062385526,-0.050037447,0.040096603,0.013337587,-0.0120640425,-3.0165427e-08,0.10061588,-0.08191396,0.019407298,-0.054394476,-0.03634329,-0.033813573,0.045974337,-0.024180083,0.06193043,0.033677492,-0.05666823,0.042183045,0.04293399,-0.004047676,-0.021756653,0.08043919,-0.0005381508,0.012399076,-0.023267038,0.0014177976,-0.054533094,0.012188924,-0.041132744,0.099677235,-0.011172741,-0.050365705,-0.034691688,-0.025575332,-0.03800268,-0.029879654,-0.01874303,0.07070401,0.027637854,-0.017466888,-0.028777905,0.040848944,0.06708057,-0.06714468,0.021986851,-0.05419466,0.03320444,-0.027186109,-0.012534871,-0.09461792,0.010611311,-0.05705645,-0.023703963,0.013693846,0.04397074,-0.022439344,-0.049464773,0.053082533,-0.08645345,-0.06725087,-0.03303654,-0.0071823047,-0.047477577,-0.040146373,0.05065939,-0.05196134,0.024796199,0.11602697,0.19952145,-0.07165621 +3.4.23.12,"From the insectivorous plants Nepenthes spp. (secretions) and Drosera peltata (ground-up leaves). Aspartic endopeptidases are probably present in many other plants, including Lotus [3] and sorghum [2]. In peptidase family A1 (pepsin A family)",384,1.0,-0.016555844,-0.023418428,-0.09331777,0.06811616,0.041042585,0.08959419,-0.010138608,0.013988645,0.040572524,-0.0011682985,0.11768799,-0.08892122,-0.08823622,-0.030243015,-0.05027306,-0.010100001,0.053649675,-0.071839765,0.011359994,-0.0520658,0.04750387,0.055937722,0.03657811,-0.020837918,-0.010855045,0.006534232,-0.11095912,-0.10573605,0.040088292,-0.1227329,-0.0158551,-0.054337684,0.08057782,-0.009931366,0.08002652,-0.00591721,-0.017409924,-0.011612899,0.10422423,-0.022575296,0.0819622,0.024356069,0.012770016,0.006046991,-0.00938925,0.045789458,-0.015336314,0.046355624,0.05133699,-0.0123987105,0.011609685,-0.040563274,-0.010222034,-0.008407995,-0.017437113,-0.0002798785,0.062238615,0.0044864155,-0.03235587,0.076070204,0.09715607,0.026722362,-0.039536193,-0.05871933,-0.07428155,-0.020412408,-0.042689394,0.006207461,0.065435365,-0.022009028,0.03526843,-0.038301103,-0.0024655233,0.04362452,-0.05917557,0.10796764,-0.023751417,-0.0011863445,-0.07223214,-0.050212543,0.017386908,0.046193577,0.060321238,0.06960043,0.0047964263,0.01677826,-0.047769755,0.07496275,-0.009421506,-0.014095295,-0.013711853,-0.06013866,-0.010514656,0.0024124247,-0.09773937,0.015536301,0.08656691,-0.10529286,-0.02051707,-0.011225228,-0.00042051746,0.010957799,0.0032855268,-0.052800052,-0.03753396,0.0764749,-0.1282078,-0.07329726,0.117754586,-0.02572512,-0.046961617,-0.02797179,-0.04037705,-0.04777842,-0.029748434,-0.08777765,-0.03247187,-0.04441825,-0.009134652,0.033738676,0.04342771,0.007971401,-0.02442631,0.046822045,0.019532533,0.05720587,-0.11866255,1.2949087e-33,0.008593522,-0.019399207,0.055024434,-0.023721378,-0.009838603,0.006884787,0.0355148,0.05949431,0.003088298,-0.086489156,-0.059809454,-0.12588309,-0.006026806,0.022327438,-0.04277462,0.014732152,-0.046964537,-0.04421671,0.11216584,-0.025147222,-0.027638843,0.0617226,-0.057584736,-0.08725565,0.028683705,-0.010459865,-0.0011280704,-0.018564114,0.059408147,-0.017318023,0.09932325,-0.06976042,-0.0034642501,0.04326254,-0.0007926778,0.017225869,0.0037625139,-0.07910571,-0.078398705,0.0015957882,-0.007828798,0.088692896,-0.018808858,0.011837552,0.02987719,-0.036956374,-0.0060835346,0.016345413,0.083441146,-0.003984967,-0.018662293,0.0043140543,0.093805835,0.038400743,-0.0047011576,0.03545146,0.023603683,0.07252382,0.014881006,0.033067644,0.028734056,0.004822952,-0.09021296,-0.091381215,-0.01604123,0.07580676,-0.09917301,0.008853588,0.012715108,0.019920059,-0.063966766,-0.029547632,0.007729776,0.008411612,0.002858523,0.038491823,-0.041961282,0.02610687,0.021296903,-0.046296023,0.01632137,0.036388814,0.04220286,-0.0013942922,-0.021031095,0.0028919664,-0.008726153,-0.022312246,-0.04883568,0.03192844,0.014460735,-0.024808558,-0.022327414,0.058993187,-0.044785324,-1.4040775e-33,-0.03443353,0.011101836,-0.024083443,-0.050309863,-0.014162641,0.071556516,-0.0389779,0.02566713,-0.0111285765,0.032023013,0.021107925,0.04187857,0.08011784,-0.035231475,-0.00046634927,0.0010987095,0.06865794,0.13781157,0.060520977,-0.067550056,-0.05687748,0.06813613,0.014630013,-0.057096027,0.07172664,0.014790848,0.0130173,0.0017450587,-0.04234625,-0.015261985,0.08019455,-0.002203809,-0.028428832,-0.028935004,-0.016083641,-0.023042535,-0.16448689,-0.044744026,0.040609755,0.068743646,-0.0048531243,0.023495186,0.113650344,0.09420316,0.08276565,-0.03545111,-0.14100158,0.056402504,0.008896959,-0.0067511396,-0.007973023,-0.09625489,-0.027756289,0.030231249,0.059370656,-0.012952584,0.026174128,0.066676505,0.017185252,-0.052477926,0.03601591,0.01659658,-0.014596148,0.0075813215,0.0591243,0.03179373,-0.0322363,0.054785192,-0.018962761,0.075870365,0.005229482,0.010901868,-0.019148067,0.022191748,-0.04839707,-0.0021555473,-0.018315569,-0.063886516,-0.0068925535,-0.028576486,-0.07195131,0.01202687,0.037071798,-0.019632747,0.03816836,-0.09228797,-0.031317342,0.029306026,0.032755375,0.11589205,-0.049104962,0.008739966,0.030819612,0.048923947,0.12665711,-3.1258825e-08,0.075408675,-0.020446993,0.038637344,-0.06662344,0.011259167,-0.063112035,0.017320026,-0.007489019,-0.016482404,-0.0063558654,0.044172753,-0.041405015,0.028364101,0.014887147,0.021170871,-0.01358264,0.10790575,0.0465485,0.0014683241,-0.0011639742,-0.07468179,0.022359261,-0.06432832,-0.06571286,-0.021437094,-0.0624038,0.025526058,-0.014676889,0.0418926,0.026322814,0.029699298,0.018482847,0.049571294,-0.08069451,0.016565507,0.08280876,-0.0046125734,-0.014216877,-0.017770194,-0.013904939,-0.003453706,-0.028297175,0.0072102337,0.015434223,0.020555232,-0.0067258016,0.07058772,0.027440341,-0.032363914,0.0010894708,0.013667848,-0.06789055,-0.0067451173,-0.013987106,-0.120738596,-0.05317134,-0.025971014,0.004611872,0.0049,-0.011060941,-0.040486977,0.04516598,0.17223518,0.104591 +3.4.23.15,Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family).,384,1.0,-0.053131774,-0.03389719,-0.114014834,-0.04044349,0.03692452,0.03627449,0.036351822,0.08248013,0.08304409,0.025269866,0.08695,-0.033536837,-0.052175652,-0.009402297,-0.089884095,-0.06811436,-0.046791058,-0.09016128,-0.03700298,-0.09175214,0.07169669,-0.0021217207,0.013720647,0.06371999,-0.02861867,-0.00015922876,0.05108462,0.012634684,0.04069263,-0.014640926,-0.0059926105,-0.061926115,0.060911547,-0.029311227,0.06564842,0.008698535,0.0058593103,-0.00912197,0.03958869,0.020314327,0.07434907,-0.048041668,-0.05754743,-0.0798836,0.03547449,-0.010149845,0.0011902027,0.11375272,0.08157222,0.048148427,-0.024546022,-0.014526909,0.004934704,-0.02504105,0.030139439,0.0008960185,-0.026238732,-0.07277753,0.030561345,0.02419433,-0.049130645,0.023738878,-0.018862674,-0.016000992,-0.004893172,-0.036980852,0.029108856,0.00908404,0.016940508,-0.041327257,0.05053345,-0.0177812,0.046469532,0.031184997,-0.06436105,0.03388433,0.0046121073,-0.09880284,-0.11152186,0.0048808814,0.05094941,0.053794414,0.061463576,0.061122015,-0.009474141,0.00042153912,0.02653643,0.018200045,-0.061523557,-0.052849323,0.0013412194,-0.054838285,0.085370585,-0.00091313396,-0.025301691,0.030050041,0.03491862,-0.115651645,0.07259854,0.015150475,-0.030227575,0.00974863,0.030074606,-0.10330408,-0.044331267,0.06891695,-0.06659295,0.12432999,0.104212336,0.07681798,0.025607154,-0.03974638,-0.031426713,-0.01771672,-0.054849878,0.05389355,-0.023972599,-0.019376047,-0.051527377,0.024301948,-0.012410858,0.03251294,-0.006095721,0.06725591,-0.016684772,0.055784922,-0.03933383,-2.2501364e-33,0.03180103,-0.03454421,0.04298545,0.043640736,0.01381151,0.058978945,-0.017293062,0.03406822,0.07965285,-0.12401881,-0.060763523,-0.10041934,-0.012520925,-0.027600987,-0.0724839,-0.023319755,-0.051129833,-0.04633557,0.06689623,0.013307696,-0.067902915,0.10297624,-0.005627533,-0.083030134,0.00026293928,0.0179574,-0.039668653,0.03912882,0.032509614,-0.03054048,0.045159064,0.005654608,-0.07640845,0.0038707785,0.027270706,0.008415803,0.012715864,-0.03786033,-0.0074989884,0.11131527,0.0044025276,-0.052488506,0.0150543945,-0.039229598,0.07790636,-0.054993596,-0.06433441,-0.01722434,0.023515075,0.048838932,0.0060870433,0.010811518,0.07865373,-0.01759301,-0.08629005,-0.03316579,-0.037555452,-0.052686807,0.057181474,0.059612688,0.07990598,0.10600382,-0.058064416,0.06451338,-0.063913934,-0.00038308697,-0.0904189,0.007953409,-0.0066073863,0.007982153,-0.03432193,0.0060874526,0.09497516,-0.023611134,0.03145788,-0.01493127,-0.0661865,0.03216229,-0.020353517,-0.0026232593,-0.031086715,0.05349531,0.07119122,0.09185988,-0.030362735,0.02765312,-0.031079296,-0.041770007,-0.010723934,0.012101805,-0.08257724,-0.06534383,-0.099694066,0.005024629,-0.047518574,-7.3606706e-34,0.07160823,-0.07702883,0.056076862,-0.04371667,-0.028834308,0.044200037,0.0051496606,0.0107351225,0.025842406,0.03504189,-0.006092821,-0.04777778,0.0251821,-0.10921505,0.0022333437,0.06771578,0.00029916165,0.07982392,-0.03862235,0.031086383,-0.035414085,-0.00014008171,0.032530002,0.025747424,0.08091745,-0.025430419,0.07858133,-0.02312089,0.055885423,-0.027007364,-0.01017714,-0.015785972,-0.07210698,-0.046639524,-0.027878722,-0.0045588003,-0.070887715,-0.046406496,0.0059089796,-0.044934776,-0.06309074,0.032018613,0.0560822,0.07903943,0.053686656,0.061288424,0.010526002,-0.017322449,-0.02858023,-0.03676377,0.0027765927,-0.0577363,-0.004343136,0.050346363,0.049489588,-0.055367317,0.018663999,0.104840346,0.015837468,0.027589912,0.031932082,-0.0030619935,0.0051831435,-0.011144879,0.057816293,-0.05429217,-0.063969776,0.020245539,0.085226774,0.02194239,0.11633087,-0.013974397,0.022838756,0.028572628,-0.05392371,0.035163812,-0.04673512,-0.053130627,-0.010021211,-0.046863537,-0.0424614,-0.037655126,-0.011390407,0.024777992,-0.040436476,-0.0072203143,0.115174055,0.04486872,0.009476456,0.058530793,0.025984745,0.025747754,-0.0061365105,0.03368008,0.012227347,-2.1215525e-08,0.12757874,-0.06842612,0.0128244795,-0.047360796,-0.063137434,-0.058658145,0.09177866,0.0053386707,0.022056432,-0.06237733,-0.040646613,0.019753834,-0.0022545217,-0.03657073,-0.013646073,0.078911565,-0.02156648,0.051291417,-0.00054213766,0.021307467,-0.07566883,-0.011632715,-0.058975697,-0.0033286312,-0.044743627,-0.08774677,0.026654685,-0.01844999,-0.016504714,-0.022130629,-0.025486838,-0.017423796,-0.03496677,-0.09376068,0.09660172,0.05741369,0.027388675,-0.005339632,-0.018039621,-0.048391093,-0.0029113118,-0.08830747,-0.005183265,-0.059655823,0.023812553,-0.01326179,-0.048089564,0.09126085,0.0066621457,0.0061980486,-0.004728327,0.03393376,-0.052494317,-0.042537156,-0.06843909,-0.0100597525,-0.012530019,-0.10749707,0.026262466,-0.047335126,0.098179676,0.08128917,0.14398982,0.06747562 +3.4.23.16,"Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2",384,1.0,-0.01572224,-0.063173145,-0.078103274,-0.069853745,0.027584571,0.009756425,0.038713645,0.05884285,0.08773077,0.04899653,0.030275524,0.07117196,0.012048539,0.02893819,-0.007040661,0.016238995,-0.088957526,-0.056817017,0.027619822,-0.033672974,0.02830748,0.0028822166,0.008891853,-0.0025141637,-0.07104499,-0.0014155477,0.044705644,0.03501862,0.030732164,-0.03392085,-0.02238982,-0.07060963,0.0954663,-0.0030349926,-0.0015685855,0.005233355,-0.08188258,0.00438764,0.034172848,-0.021617679,0.06967656,-0.0090642795,-0.03733403,-0.03439416,-0.0017210846,-0.08609581,-0.04214801,0.06568525,0.06941202,-0.008063684,0.032731965,-0.07517219,-0.046375096,0.041528106,-0.019408023,0.019399881,-0.14314179,0.03976945,0.048201736,0.054292187,0.051877864,0.10810558,0.053269953,-0.046827637,-0.01300548,-0.04081176,0.03666559,0.0051801056,0.032166727,-0.014106887,-0.03524041,-0.07280514,-0.14359635,0.06923206,-0.04912262,-0.023152687,-0.005487674,-0.059342515,-0.040737536,0.004446284,-0.03398549,-0.043182235,0.075969614,0.0412993,0.00067244185,0.03525569,-0.0051304004,0.0064376737,0.07197119,-0.0445145,0.018066535,-0.053089336,0.05622279,-0.015310852,0.01302342,-0.045059133,0.008229542,0.030265119,-0.013906245,0.03668585,-0.012360764,-0.016732853,0.01986379,-0.0012815048,-0.011333913,0.07220283,0.03824665,0.013200611,0.014445404,-0.01281436,-0.023832098,-0.028454728,0.0032976866,-0.03650845,0.0222099,-0.02667675,-0.018954998,0.0008848158,-0.036998827,-0.036587752,0.047427565,0.0007727043,0.12881747,0.031798273,-0.034945033,-0.010394368,-0.017949646,1.8584079e-33,-0.01332321,-0.018703444,0.030780124,0.03814559,-0.026690053,0.05133869,0.057301063,0.050841846,0.016554527,-0.048722923,-0.07079735,-0.08412115,0.02101536,0.105492786,-0.082811266,-0.0067034513,0.0025771651,0.0036097784,-0.02842278,0.059209075,0.056992292,0.07997377,-0.0013602911,-0.024300998,0.043188587,0.00064005476,-0.012349008,0.03327284,0.00499243,-0.035558768,-0.014897049,0.050730903,-0.1429195,-0.0018917813,-0.070195235,0.022438832,0.04465319,0.007494925,0.025406653,0.025200564,0.06280392,0.005649867,0.06562714,-0.08351027,0.09161287,0.01444002,-0.056945737,0.042902768,0.0016045818,0.010696882,-0.0073199277,-0.022263797,0.010455553,-0.009775213,-0.0726497,0.0010679588,0.021633698,0.10360668,0.05462188,0.028477434,0.024644874,-0.025237909,-0.011840496,0.035150573,-0.055021655,-0.029226363,-0.029940471,-0.055936597,-0.02605548,0.18427737,-0.040899605,-0.013432222,0.03197375,-0.00855119,0.098111786,-0.08551596,-0.10289069,-0.025927281,0.018128777,0.077017576,-0.11431098,-0.04351846,0.06577571,-0.023512049,-0.078484446,-0.039002728,-0.006148855,-0.06673712,-0.085907064,0.023487046,0.053340912,0.0001191021,-0.07990023,0.1100204,0.010155124,-3.9826865e-33,0.05430493,-0.025154335,0.019682955,-0.08571807,-0.05208426,0.1267693,0.10676684,0.00018983021,0.0045923195,-0.0075124945,0.034950297,-0.005461383,-0.0077390196,-0.04314386,0.06749202,0.043154567,-0.007877862,0.10402898,-0.012497286,0.02781338,-0.10620225,0.04913883,0.002147867,-0.0034665563,0.03545323,-0.059469976,0.028473409,0.079913914,0.015143516,-0.03880542,-0.1051381,0.039723434,0.0049493047,-0.01086279,-0.062221527,0.030072033,0.01961401,-0.050954122,-0.007730349,-0.05217739,0.054969493,0.0662832,-0.001028848,0.113533616,-0.049913485,0.07024457,-0.00086610735,0.05746507,0.028103892,-0.062132835,0.024607481,-0.03484575,0.037316836,0.035246253,0.03900768,-0.009419974,-0.032439604,0.06674839,-0.016413076,0.047353387,-0.037327148,-0.010592852,0.048535407,0.0052638096,0.02238531,0.012423671,-0.057483025,0.015462527,0.019368034,-0.044085838,0.064900815,-0.029882656,-0.014018232,-0.06252403,-0.04541385,-0.06247668,-0.050906353,-0.062029887,-0.009306069,-0.11225988,5.509104e-05,-0.045343723,-0.054537952,-0.011712571,-0.025019197,-0.0038975354,0.020021256,0.047100984,0.016941108,0.114754215,0.011264887,-0.007558356,-0.03430986,0.01311192,-0.012382827,-3.876306e-08,0.060752757,0.0024778289,0.038956076,-0.05858492,-0.020017672,0.036487553,-0.08523726,0.033933576,0.034120686,-0.0095739085,-0.027670419,-0.0020028665,-0.0050884406,0.039835032,0.032686915,0.06346976,-0.13217616,0.08444144,-0.0578629,0.031610228,-0.033688042,0.03705148,-0.11055324,0.009881108,-0.0379533,-0.007722347,-0.014241262,-0.0039703995,0.031421587,-0.024675729,-0.009108854,0.031843793,0.0155428555,-0.024846671,-0.036358096,0.026949003,0.04975481,-0.056833226,-0.012507365,-0.06051957,0.06875802,-0.1333763,-0.047164306,-0.0656811,0.040042955,-0.0023833627,-0.078750975,-0.04401247,0.014901196,-0.040547222,0.01831472,0.036175545,-0.044852436,-0.04484662,-0.086607516,0.016523067,-0.04878685,-0.07447705,0.06559543,-0.09273179,0.06717117,-0.013485427,0.16979586,-0.0056935726 +3.4.23.17,A 70 kDa membrane-bound enzyme isolated from cattle pituitary secretory vesicle.,384,1.0,-0.027058452,-0.042225588,-0.075264454,-0.0016833057,0.011703287,0.008195686,0.04432157,0.08390274,0.04902298,0.021301115,0.021326913,-0.04766014,-0.08211535,0.08931991,0.049409382,0.025536355,-0.028078577,-0.045520376,0.047878053,-0.08225265,0.09824355,0.036684982,-0.029504651,-0.0115868,0.03239645,-0.049943253,0.063827075,-0.020996489,-0.070556015,-0.022946281,-0.13537388,-0.06616927,0.021979196,-0.01764278,0.03470894,-0.036958296,-0.046919294,-0.004012265,0.026406532,0.032052618,0.053055912,-0.020251382,-0.06061763,0.0056200456,-0.04894842,0.07008532,0.022348082,0.0675594,0.053721733,0.033500046,-0.041921552,-0.09224825,0.019127382,0.055275805,-0.04833234,-0.016100772,-0.056448963,0.030019948,-0.025505653,0.13006148,0.013712278,0.041857257,0.040438935,0.02152365,0.03085854,-0.096403226,0.008073675,0.08448172,0.03116848,-0.026316367,0.05993449,-0.07352558,-0.023668654,-0.059102863,-0.0040891855,0.02008356,-0.0017215258,0.011599173,0.08710878,-0.086030334,0.06542108,0.0043122573,0.003347233,0.022458697,0.008840877,-0.0167212,0.07695646,0.022996796,-0.047207225,-0.06845027,-0.024780529,-0.11034258,-0.07954287,-0.017726691,0.05652057,-0.031444468,-0.032162268,0.0031925854,-0.08620705,-0.008052151,-0.015979968,0.025304368,0.05006227,-0.041604083,-0.007960959,0.04833302,-0.005108816,0.05229899,0.035284866,0.0073339907,-0.028079156,0.05833317,0.054826938,0.0711229,0.08887491,0.015675006,-0.0223966,0.010312457,-0.049072817,0.037969396,-0.0051926277,0.044646136,0.034588788,0.09386042,-0.016757578,0.055938724,-0.01932728,8.148515e-34,0.0400242,-0.039693326,-0.042611066,-0.06473624,-0.038504157,-0.00078908977,0.0012939867,-0.007611631,-0.044086564,0.08956039,-0.08436707,-0.10835025,0.0015293199,0.039978538,-0.00966528,-0.032619804,-0.002406856,0.03508109,0.108028725,-0.0064060637,0.024671348,0.089634866,-0.015034475,-0.058127943,0.039016202,-0.041187696,-0.055336583,0.025601521,0.042297345,-0.003082083,0.016344536,-0.13456072,0.045508545,0.009180055,0.015515326,-0.045886043,-0.020575315,-0.07099632,0.009038561,-0.044998433,0.02722476,-0.03187038,0.04969618,0.0027020203,-0.021067569,-0.007866143,-0.09471851,0.03685048,0.010740314,-0.054464176,-0.007156414,0.02292123,0.052369293,-0.07778933,0.0056915735,-0.010826421,-0.011018563,0.02953867,0.02947148,0.005445945,0.0041553085,0.07896937,-0.11857191,0.050572623,0.05196085,0.019257318,-0.113358624,-0.072288744,-0.03872958,0.07810398,-0.070037976,0.02301628,0.01369814,-0.11927524,0.01675883,-0.07650869,0.013244853,0.013400734,-0.06147358,-0.012077703,0.036766488,-0.061030928,-0.023429662,0.058489874,-0.09087116,-0.00021785859,0.010585383,0.031511705,0.004404489,-0.039273042,0.04223388,0.0051239235,-0.034549627,0.023077935,0.05192656,-1.1326828e-33,0.06937565,-0.023125026,0.106202394,-0.01788443,0.020549508,0.094461255,0.0444136,0.039336093,-0.046954732,-0.027028337,-0.010286527,0.038088452,0.03503002,-0.06301254,0.06301941,0.06472235,-0.09054472,0.06097587,0.016666183,-0.043914206,-0.10984341,0.06182999,0.0006118584,0.055022854,0.05379406,-0.018678095,-0.02253339,0.011762858,-0.027133878,-0.0025428887,-0.060971476,-0.014952301,-0.07330775,-0.020299967,-0.041711792,-0.07542994,-0.025870364,-0.07061846,0.032286,-0.009854936,-0.009292507,0.06609671,-0.00057042495,-0.017157914,-0.0013208798,0.099861495,-0.004923119,-0.015128253,0.02360944,-0.06628796,0.009816672,-0.017207528,0.016365513,-0.07086406,0.027272526,-0.006565448,-0.040980857,0.024819963,0.050442975,-0.038797833,0.017017886,-0.07026906,0.08676517,-0.04988761,0.03402975,-0.0010629974,-0.03666142,0.07726178,0.0022511813,-0.01571931,0.060264237,0.011097237,-0.014449348,0.08106994,-0.0045861956,-0.00048481624,-0.05026925,-0.060013253,0.026631445,0.03513646,0.0780724,-0.043818027,-0.04816872,0.016713656,0.15173313,0.05066542,0.028326139,0.13809317,0.055420298,0.059197146,-0.05168702,-0.051486794,-0.036601182,0.03155413,0.117432006,-2.2633683e-08,0.10387943,-0.05886767,0.023734696,-0.07640902,0.022214312,0.013997045,-0.013186538,0.027215881,0.02934159,-0.012768536,-0.0568476,0.042214222,-0.02674017,0.05609021,-0.03913136,0.030421978,-0.033329636,0.01799771,0.05558093,-0.05632428,-0.032146268,-0.022789583,-0.098850004,-0.0071387268,0.016881,-0.03699843,0.04218408,0.09886265,-0.013636475,-0.01499151,-0.030836197,-0.038416393,-0.0088538565,0.005040086,0.0014138614,0.07744748,-0.0805269,0.045833834,-0.01023963,0.08149284,0.014986019,-0.022446565,0.07288045,-0.017656041,-0.095199086,-0.01323628,0.09084747,0.0023361745,-0.03870637,-0.012832789,-0.028143212,0.016558431,0.005033169,0.0036121462,0.0084863175,0.00846778,-0.10500701,-0.12194331,0.010444737,-0.028943881,-0.027297152,0.029633183,0.12551273,-0.023650682 +3.4.23.18,"Found in a variety of Aspergillus species (imperfect fungi): Aspergillus awamori (awamorin, aspergillopepsin A: [8]), A. foetidus (aspergillopepsin F: [6]), A. fumigatus [7], A. kawachii [9], A. niger (proteinase B, proctase B: [2,4]), A. oryzae (trypsinogen kinase: [3,10]), A. saitoi (aspergillopeptidase A: [10]), and A. sojae [5,10]. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6",384,1.0,-0.06905407,-0.01634307,-0.1390113,-0.017638875,0.09431064,0.046130374,-0.049913377,0.056946598,0.055708397,-0.058989935,0.09514449,-0.09996789,-0.031209143,0.072871745,-0.12427761,-0.0015864463,0.043270286,-0.049283214,0.012626573,-0.059337847,0.03493364,0.05587211,0.08211056,0.0621204,-0.04040617,-0.029330699,0.044895362,-0.027008869,-0.01466156,-0.14245695,-0.07070322,-0.02681216,0.06336449,-0.015779825,0.081180826,0.06413304,-0.032814875,-0.01090751,0.105899215,-0.039170872,0.044326555,-0.018454704,0.005166672,-0.078518085,-0.043882802,-0.005595852,-0.016552353,0.08908015,0.10562863,-0.015633732,-0.05520892,-0.04061033,0.015919667,-0.010856308,0.06854469,0.034025475,-0.027896766,-0.07637082,-0.012273839,0.023536472,0.045785278,-0.03921392,-0.011784253,-0.021935204,-0.08421717,0.06670511,0.03026617,-0.03356643,-0.0022018137,-0.016396536,-0.015495524,-0.013619807,0.016712941,0.14397311,-0.00451068,0.10885014,0.024731433,-0.036775008,-0.027260583,-0.047779117,-0.002385145,0.0067055942,0.07203496,0.03743026,0.0075962166,-0.07737672,0.0084401285,0.049259815,0.012172017,-0.023853876,0.05107444,0.009968425,0.063591264,-0.054179817,-0.01652546,0.02209723,0.03799925,-0.0043633035,0.020626646,-0.043461412,0.02044631,-0.060382463,0.04320821,-0.04495193,0.02192353,0.037577152,-0.06649305,0.035601866,0.17254487,0.0022478926,-0.013113816,-0.011660759,0.0077210334,-0.029580258,0.006946205,-0.05167995,0.004340714,-0.017640352,-0.050546348,0.064725354,0.008362248,0.035663243,0.0023692364,0.01959043,0.0011342979,0.07254617,-0.13830745,8.741322e-34,0.0034290305,0.054300684,0.016290953,-0.0150085855,0.024116548,-0.022695024,-0.027480721,0.03288993,-0.007850957,-0.08495894,-0.07253184,-0.08145104,-0.05009657,0.048411094,-0.019592823,-0.020097466,0.0067523066,-0.04410754,-0.039141674,0.013081085,-0.0334448,0.06489442,-0.045257222,-0.029514167,0.026299559,0.039855603,0.0038581595,0.0057597803,0.054672677,-0.035633672,0.012344573,-0.03234494,-0.09936036,0.0119976085,0.08265424,-0.0071948566,0.05209046,-0.06977849,-0.04235441,0.02316216,-0.04755225,0.04629688,-0.04962884,-0.048096567,0.06413932,-0.07690945,-0.02641546,0.03963433,0.08021141,0.012207949,0.018866904,-0.03303607,0.057024892,0.008060623,-0.037399556,-0.01686858,-0.028375706,0.03150409,0.08333915,0.069810994,0.04625546,0.017189555,-0.06435538,0.017439423,-0.04101475,0.0036257198,-0.07937226,-0.018509284,-0.01588264,0.010156477,0.020492872,0.013839717,0.021188628,-0.0070363823,-0.0050485553,-0.05882356,-0.033376172,-0.024161043,-0.001586746,0.03826419,-0.006032399,0.006864283,0.01263835,-0.009611343,-0.15528382,0.002198935,0.0062419674,-0.024297586,-0.023832263,0.015071767,-0.07399226,-0.056998134,-0.044073597,0.05186531,-0.013536983,-3.4257406e-33,0.10609164,-0.08368059,0.090423405,-0.029447703,-0.06602954,0.08023319,0.07813176,0.05053759,0.023432212,-0.098078825,0.06760787,0.017633459,0.09919358,-0.015868796,0.018148033,0.07342802,-0.02427385,0.10313371,0.0037025292,-0.02236029,-0.051668108,0.01167481,-0.008027555,0.048632316,0.08966747,0.06504017,-0.0077706636,0.025829265,-0.05321031,0.011704437,-0.01769892,0.05768099,-0.056330618,-0.03885077,-0.030363534,0.022994153,-0.02810811,-0.046463963,-0.0110166045,-0.0044791535,-0.026006673,0.05844321,0.015776906,0.10885176,0.020039037,0.09271759,-0.012356445,0.020514779,0.029313203,-0.06651505,-0.0116641885,-0.008098934,-0.04925538,0.025382143,-0.0031399028,-0.045056306,0.049067892,0.039707728,-0.009025992,-0.02466314,-0.10636129,-0.0083691655,0.025792703,0.047290314,0.049897,0.029796457,-0.06354208,-0.049001634,0.1251976,0.0057555325,0.058719628,-0.010269979,-0.009863988,-0.021686627,-0.025837854,0.08049099,-0.02975969,-0.016438296,0.008763758,-0.012639451,-0.016863735,-0.03766786,0.018960206,0.0106709255,-0.059767924,-0.044267964,0.08535486,0.032323275,-0.025316346,0.075123325,-0.0022396308,-0.0044853007,-0.010487588,0.047071207,0.089242555,-4.9146603e-08,0.11931833,-0.012774089,0.058731325,-0.10938723,0.016935915,-0.015959458,0.03142695,-0.028498875,0.033653446,-0.023740117,-0.065403454,0.023112614,-0.05475773,0.0133055225,0.017791128,-0.03283747,-0.0157261,0.07380972,0.022713378,0.038895193,-0.06570848,-0.0031741678,-0.069152854,-0.009048758,-0.023986144,-0.09152627,0.028792597,-0.014974705,0.040084306,0.02323524,-0.054079626,0.020221656,-0.002696512,-0.085215546,0.0844573,0.039581053,-0.061379585,-0.019567981,-0.030150356,0.011738029,0.017408926,-0.08932838,-0.049531523,-0.07677702,-0.055270508,-0.06313685,0.04289437,0.041322008,-0.017014153,-0.044240464,0.04307066,-0.032641586,-0.062984824,-0.019336553,-0.073763326,-0.016148217,0.009004874,-0.09066575,-0.05994687,-0.06449161,0.010429963,-0.043625403,0.122064546,0.014988577 +3.4.23.19,"Isolated from Aspergillus niger var. macrosporus, distinct from proteinase B (see aspergillopepsin I) in specificity and insensitivity to pepstatin. In peptidase family G1 (scytalidopepsin B family). Formerly included in EC 3.4.23.6",384,1.0,-0.06987641,-0.030751351,-0.12569039,-0.00034990997,0.120569825,0.095482364,-0.008022733,0.11012638,-0.014699215,-0.05978959,0.054872844,-0.035506114,-0.004896739,0.047704197,-0.089291945,0.0016220395,0.037773702,-0.06933773,-0.0017494933,-0.068702795,0.016623072,0.063557565,0.0056671863,0.06421059,0.017936816,-0.005955724,0.006639161,-0.0355493,0.002808405,-0.03656863,-0.063875854,-0.073511146,0.041932505,-0.021906618,0.11791441,0.042251084,-0.03315703,0.03917842,0.105034865,0.001061998,0.013852201,0.00984476,-0.001980716,-0.094301544,0.042005833,0.012184506,-0.01579842,0.06575532,0.07111929,-0.029127965,-0.06988115,-0.05926024,0.003980594,0.036362324,0.05428019,0.025389215,-0.0492261,-0.08352793,-0.013453143,0.028958678,0.013975429,-0.03829988,0.0101918625,-0.028168986,-0.053971134,0.012919134,0.03616618,-0.025007285,0.040844295,-0.02812936,0.008611589,-0.023128692,-0.040917967,0.10840827,-0.0063364985,0.064123146,-0.01823278,-0.03315352,-0.0511876,-0.027546499,0.04971278,0.013759782,0.06692761,0.011422343,-0.041682027,-0.07637305,0.05278139,0.064293295,0.040529534,-0.029762894,0.036070976,0.024155455,0.07903601,0.016171817,-0.018795937,0.0027029295,-0.0020875034,-0.0057506515,0.04678103,0.035289474,0.032585282,-0.051349733,0.07850269,-0.012369269,-0.0014672446,0.0806819,-0.02334126,-0.012530425,0.12631904,-0.0039051082,0.0013340663,0.01487821,-0.011614701,-0.06525957,0.053238366,-0.023093611,0.033288993,-0.013259654,0.023275696,0.03795407,0.066485025,0.03177028,0.059171885,0.016543714,-0.0003754982,0.09477114,-0.047775947,4.080116e-33,0.010675005,-0.030371176,0.025397291,0.0017254238,0.004239147,0.029511651,-0.02218613,0.0061870185,-0.009321807,-0.08629556,-0.100158036,-0.03912717,-0.05581769,0.016067814,-0.051012475,0.027423885,0.052918438,-0.012883363,0.047042985,-0.006427747,-0.012003398,0.056090605,-0.091368474,0.010753058,0.059596233,-0.0084657315,-0.010052681,-0.05971824,0.07265866,-0.02730214,0.02464652,-0.019700216,-0.13794875,-0.023321183,0.011984873,-0.05033873,0.0010191882,-0.090463325,-0.025282213,0.019747911,-0.02340618,0.01950144,0.009759367,-0.060775213,0.06354324,-0.003405021,-0.08470591,0.010921422,0.032346245,0.0053466167,0.026373243,-0.025005464,0.03526934,-0.007299441,-0.028758911,-0.0029312356,-0.03890679,0.04437651,0.11582655,0.08045096,0.046392895,0.040861856,-0.028132549,-0.013395835,-0.0036945364,-0.019600585,-0.07887193,0.023137625,-0.015743466,-0.0009688804,-0.037575398,0.025670208,-0.0082452595,-0.015070776,-0.018648798,-0.14137326,-0.008629407,-0.023436511,-0.029940682,0.04152391,-0.058244452,0.03003565,0.043956127,0.02569527,-0.16643064,0.031918533,0.0060305316,0.0031403706,-0.0232963,-0.012278424,-0.070361786,0.0076378724,-0.10896872,0.07555154,-0.05642883,-4.545808e-33,0.10194439,-0.035088766,0.04643684,0.008926425,-0.10160981,0.084228754,0.04490716,0.048874352,0.013680141,-0.046737902,0.022273136,-0.019833537,0.08811943,-0.06279746,0.015851723,0.04622894,-0.043447558,0.093699425,-0.01464092,0.055862688,-0.09142495,-0.018043267,0.029173257,0.04685572,0.042609062,0.027536845,-0.021337809,0.043139838,-0.012768325,0.021634543,-0.00073867996,0.07685923,-0.08733161,-0.052301656,-0.09514396,-0.0031774105,-0.054926667,-0.060954604,0.015923787,0.008961605,8.293985e-05,0.14541513,0.015576378,0.06589356,0.0027084623,0.106335685,0.04655056,0.029434523,0.008909539,-0.09862606,-0.024915576,-0.004687179,-3.848625e-05,-0.02909272,0.027942415,-0.08675004,0.039236363,0.053848915,-0.0058451523,0.009701333,0.02026329,0.011378737,-0.050560284,0.040183056,0.090752214,0.092235215,-0.06633084,-0.03709807,0.105785124,-0.036200423,0.03502569,-0.02978088,0.0357411,0.0039512254,0.009217678,0.09096118,-0.03603152,-0.027591474,-0.031257596,-0.021452462,0.049163073,-0.06567069,0.04427896,-0.035460144,-0.09130538,-0.07306577,0.06028515,0.016172431,0.013653956,0.03593826,-0.033655524,0.022380255,-0.018859865,0.04844994,0.04738573,-3.4772224e-08,0.14672692,0.042299792,0.06084411,-0.05407148,-0.05113782,-0.006924347,0.00082626514,-0.04841364,0.038723636,0.017612666,-0.1038415,-0.11059757,-0.009286056,0.055051316,0.0020715538,0.037807386,-0.06909592,0.036128826,0.029946066,0.07412497,-0.04877135,-0.023190353,-0.05309122,-0.003785529,-0.009120598,-0.05444015,0.031414274,0.03927171,0.04441179,0.011485711,-0.034423593,0.014367056,-0.044694036,-0.025965644,0.05078995,0.03377164,-0.043843515,-0.015859846,-0.015773037,-0.006312767,-0.020234069,-0.101503775,-0.041941676,-0.09148303,-0.089598835,-0.063429065,0.018623343,0.006715959,-0.003326447,-0.016399167,0.060947392,-0.051253803,0.0018064698,-0.025628807,-0.033487946,-0.0077793505,0.01116173,-0.07361002,-0.046480175,-0.0950931,-0.06313106,-0.041632444,0.06827009,0.064224854 +3.4.23.20,From the imperfect fungus Penicillium janthinellum. In peptidase family A1 (pepsin A family). Closely related enzymes have been isolated from P. roqueforti [2] and P. duponti [3].,384,0.99999994,-0.03466813,-0.025942937,-0.13180335,-0.00783358,0.08953901,0.015248163,-0.049510505,0.01903872,0.05453372,-0.059034992,0.089413375,-0.0017223025,1.3488531e-06,0.0460873,-0.08013777,0.0015336495,-0.040201675,-0.02076652,-0.026110884,-0.048349526,0.0403936,0.013016454,0.07353615,-0.0011039216,-0.051606555,0.011289102,0.07045305,-0.03941087,0.02368975,-0.099623255,0.003514839,-0.044275597,0.05906863,-0.12142352,0.12156036,0.016610224,-0.036784783,0.027226511,0.12605165,0.004723939,0.048192587,-0.034305084,0.029136358,-0.059898783,-0.04951868,-0.03572108,-0.023582553,0.096021935,0.093102776,-0.007999873,-0.09895153,-0.07446327,0.01921689,-0.058985446,0.07264656,0.08273608,0.011303009,-0.062178705,-0.000118167,0.024888685,0.059732497,0.020792156,-0.012824995,-0.013181872,-0.10463181,0.0034350974,0.032785732,-0.03747569,0.088623725,-0.008017015,0.0070100073,-0.023727188,-0.047374427,0.050537143,0.0025080414,0.060282763,-0.019863829,-0.021427354,-0.04623678,-0.0072113033,-0.02369879,-0.03553035,0.031274416,0.025762524,-0.0068790014,-0.02975167,0.030878892,0.02619176,0.05661148,-0.025142247,0.00048838765,0.034967262,0.027400393,-0.04313109,-0.054653004,-0.0124218175,0.06025825,-0.034906052,0.014130291,0.01502478,0.05113226,-0.044803564,0.00057955796,-0.06521583,-0.055835113,0.034101613,-0.11065789,0.03566907,0.0709696,0.021833302,0.010145994,0.024073847,0.06167624,-0.0768877,-0.0100675635,-0.0269878,0.024412163,-0.0019846489,-0.015697181,0.04323837,-0.002178309,0.03899277,-0.0031510117,0.014357686,0.041872423,0.077272445,-0.09735244,8.768249e-34,0.03436438,0.037988022,0.031029066,0.01274452,0.038316227,0.010206391,-0.0036784508,0.060376525,-0.009987269,-0.099323966,-0.06384061,-0.061965115,-0.07361661,-0.027628472,-0.06875592,0.05331255,0.02921568,-0.057182323,-0.004871881,0.048829537,0.0035719688,0.05099006,-0.046332017,-0.03401539,0.024929432,0.028766582,0.067793846,0.01273624,0.08717811,-0.014216901,0.044140406,-0.045607936,-0.06124777,-0.0034186083,0.029739365,0.0344757,0.020909142,-0.08158093,-0.034668125,0.05744551,0.006399133,0.059251808,0.082985245,-0.07626059,0.054190543,-0.001898906,-0.021690028,0.058410954,0.0811625,-0.010108601,-0.010811078,0.016741997,0.061154015,-0.0012274393,-0.0725694,-0.049114272,-0.007331395,0.04532036,0.07229574,0.05925224,0.047737677,0.07498009,-0.070445485,0.036043525,-0.020939644,0.036857124,-0.0682477,-0.011903791,-0.019439448,0.011435669,-0.026465127,0.012945538,-0.008378397,-0.030104514,0.05289438,-0.09126958,-0.053135708,-0.024430396,-0.011564123,0.0021209845,-0.04018921,0.048672482,0.061127342,-0.0071412,-0.093446046,-0.056002863,-0.059747238,0.021858638,-0.067218564,0.053662132,-0.04936571,-0.0792891,-0.08524755,0.10916517,-0.007505081,-1.8811291e-33,0.057772014,-0.085505836,0.105614156,-0.02667007,-0.05053676,0.07322225,-0.0137733845,0.04485455,0.04263358,-0.035280928,0.020735119,0.0060084215,0.07326983,-0.031946816,0.030826936,0.071442455,0.02825527,0.13548486,0.004129336,0.0036610106,-0.08413325,0.05086066,0.0016479032,-0.043998186,0.07012332,0.015620098,0.05381136,0.0786888,-0.060528036,0.00033507732,0.0033268253,0.046725687,-0.061746903,-0.066113174,-0.073468976,0.019142875,-0.064853966,-0.07386568,0.048877504,0.043856554,-0.04642269,-0.00844769,0.00807001,0.084261276,0.025371544,0.0056024287,-0.07709818,-0.003963981,-0.020215647,-0.043444622,0.017123062,-0.029747898,0.0125426985,-0.0058711465,0.048213143,-0.025537131,0.024768744,0.087543495,0.040606838,-0.0206645,-0.02342496,0.048959017,-0.026981998,0.077931054,0.036351677,0.08406667,-0.053736996,0.034606498,0.042310204,-0.013710307,0.043442313,0.06328602,0.014703253,0.054401465,-0.0025087951,0.12254113,-0.08795824,0.003047469,-0.031263303,0.013453955,0.016651824,-0.07444085,0.044376686,-0.008436358,-0.049136385,-0.032832798,0.07642016,-0.012776198,-0.0012912647,0.07822964,0.0070456467,0.0047693597,-0.026569178,0.02357074,0.08586827,-3.2365648e-08,0.07168372,-0.04623507,-0.016204504,-0.073595084,-0.04806128,-0.048951354,0.027227983,-0.02097274,0.002368174,0.007884526,-0.07091424,0.012613792,-0.020120023,0.023149204,0.0017213627,0.06849488,-0.034156878,0.026054842,-0.0011309502,0.08408766,-0.054862916,0.040558435,-0.059575602,-0.01023958,-0.038213905,-0.08038196,0.054065857,-0.035126705,-0.013504208,-0.015240208,-0.02278552,-0.02691122,-0.04104627,-0.083722,-0.013964832,0.02770888,-0.042130765,-0.07307468,-0.05676234,-0.006247413,0.077130705,-0.104579546,-0.07108211,-0.0853863,-0.009320741,-0.052542716,-0.041986894,0.028199354,-0.020632854,-0.04970385,-0.0041847774,0.0032373052,-0.034402456,-0.05253149,-0.07835406,-0.026900308,0.03656209,-0.07418171,-0.04765577,-0.07079749,-0.0026428327,0.024330862,0.18841639,0.05710651 +3.4.23.21,From the zygomycete fungus Rhizopus chinensis. A similar endopeptidase is found in R. niveus [2]. In peptidase family A1 (pepsin A family).,384,1.0,-0.000226619,0.013566556,-0.086513035,-0.013359274,0.09753818,0.04365031,-0.003832343,0.07975878,0.009890098,0.053494345,0.0770905,-0.05718767,-0.05028762,0.07780489,-0.07147963,0.011522292,-0.0043799803,-0.047011074,0.021822615,-0.044399705,0.08443868,0.07620534,0.09726911,-0.014585218,-0.020280158,-0.020453157,9.963589e-05,-0.08658846,0.0070431614,-0.087477215,0.041201018,-0.09087439,0.038699605,-0.022430982,0.07635629,0.012610676,-0.016498797,0.014859365,0.08801398,-0.02698337,0.01645869,0.034789674,0.0077042594,0.024489239,-0.031421088,0.10154514,-0.018155497,0.07655561,0.054689195,0.031398468,-0.05443433,-0.12856248,-0.0092386175,-0.02687036,0.094652325,0.123177715,0.017258178,-0.08286266,-0.03669064,0.049823325,0.119171165,-0.019255405,-0.04304459,-0.042851288,-0.053490423,-0.0274747,0.04290433,-0.0025137071,0.015762664,-0.06854693,-0.001972178,-0.03191485,-0.042786255,0.027027974,-0.029315094,0.070221364,0.036220036,-0.04475268,-0.06515669,-0.051009536,-0.015807018,0.002259488,0.13665593,0.014256163,0.021591352,-0.020941874,0.0060185976,0.05103083,0.006122839,-0.019856855,0.021702588,-0.0138532445,0.0088884635,-0.019376118,-0.034209624,-0.006238376,-0.0045907623,-0.034802884,0.01745856,-0.013333363,0.06992731,-0.044246938,0.04289297,-0.09476922,-0.03212605,0.08008125,-0.09501181,0.055874698,0.121125534,-0.0074347416,-0.012718371,0.008706123,0.005506173,-0.05076428,0.021402868,-0.017632985,0.027861005,0.02166859,-0.061510492,0.021424927,0.019757085,0.05227117,-0.017096167,-0.032766096,-0.012580053,0.1075569,-0.08586877,1.2631164e-33,0.004802821,0.019769767,-0.013682785,-0.047372743,0.027919358,0.07276457,0.019253578,0.04885705,-0.026428277,-0.072827674,-0.08992979,-0.09500599,-0.07199104,0.0056498093,-0.077826634,0.047938243,-0.05628987,-0.0106987525,-0.0027807595,0.06312412,-0.002597153,0.027972816,-0.027155273,-0.08379588,0.060246494,0.05888976,-0.007864358,-0.03317135,0.07563461,-0.015644506,0.019509247,-0.057937305,-0.077985175,0.027183775,0.032667395,-0.0028839794,0.084059,-0.09854332,-0.017761918,-0.023822658,0.032978572,0.03845913,-0.02677773,-0.008193608,0.03889122,-0.07132501,-0.0053532906,0.022355264,0.059114885,-0.026764685,-0.011624177,-0.024077585,0.06564536,0.000889448,-0.053400706,-0.012755443,-0.002077545,0.07964343,0.08088177,-0.01755348,0.021655653,0.071127735,-0.022051778,-0.026304122,0.012273716,-0.005671538,-0.05831795,-0.020997323,-0.031582184,0.022806788,-0.001937912,-0.009285567,0.0066954424,-0.008390422,0.005158646,-0.106609076,-0.09557259,-0.013060639,0.03523758,-0.05457492,0.06850722,0.0627522,0.0069210897,-0.014046032,-0.012042148,0.011837016,-0.032009277,-0.045146324,-0.049983285,0.074436896,-0.08223705,-0.034461964,-0.05072461,0.055578068,-0.062563404,-9.908691e-34,0.018008877,-0.028810704,-0.010863519,0.011993014,0.013938011,0.04615319,0.00032749114,0.060907956,-0.01953459,-0.08771983,0.07903696,-0.059647582,0.11433771,-0.019283349,0.022450162,0.017578745,0.022266233,0.08993539,0.08185854,-0.064557225,-0.034147616,-0.011797245,-0.010553218,-0.014403524,0.10391592,0.033678506,-0.0078059435,0.03768722,-0.023125883,-0.010717037,-0.001960068,0.028052049,0.0076554734,-0.099467985,-0.04892853,0.04368591,-0.13444088,-0.04496753,0.050406944,0.047080036,0.00200513,-0.005467898,0.06055673,0.106131926,0.0036922134,-0.011230136,-0.116326794,0.028068453,0.0074354024,-0.04592406,-0.004275984,-0.067941524,-0.011370901,-0.025935572,0.019647144,-0.036202002,0.007722614,0.07232073,0.023698136,-0.041468184,-0.03785116,0.032667577,0.0052537033,0.061658703,0.12352678,0.043503497,-0.058992304,0.075641535,0.043296665,0.004182419,0.055828314,0.022654168,0.037204627,0.02545475,-0.0328916,0.080037355,-0.05065662,-0.03014413,0.047043756,-0.013043328,0.0021181193,-0.01690499,0.0972285,0.022269314,0.017901795,-0.088378884,0.02061658,0.075746916,-0.044404477,0.07623999,-0.038123176,0.014984886,-0.027334236,0.032988977,0.06056303,-2.8773272e-08,0.110435456,-0.0456561,0.07323853,-0.10582421,-0.014693002,-0.051747285,0.080027945,-0.015679363,0.0030176109,-0.029547608,0.008471141,0.011138808,0.036212254,0.088962674,-0.014829553,0.010592346,0.03855517,0.06860935,0.010257202,0.037007205,-0.08327997,0.026458958,-0.051794596,-0.05305304,-0.018052997,-0.034646265,0.010017316,0.0038541262,0.007769286,-0.02807804,-0.02200968,0.021117434,-0.00365821,-0.02380141,0.02999801,0.096207194,-0.050980795,-0.010564254,-0.046192896,-0.054656155,0.016188748,-0.053158786,0.009587133,-0.023988405,-0.041136578,-0.0937437,0.08297348,0.0302366,-0.024643483,-0.02554472,-0.019525355,-0.042512316,-0.03397349,-0.06711651,-0.08672166,-0.06464912,0.0026199701,-0.035466176,-0.038470663,-0.086817004,-0.038766094,-0.0055128373,0.12161397,0.05482472 +3.4.23.22,From the ascomycete Endothia parasitica. In peptidase family A1 (pepsin A family).,384,1.0,-0.007803265,0.039430924,-0.12610064,0.023768505,0.011795732,0.0352392,-0.0336047,0.054386728,0.013762695,0.012224406,0.059803918,-0.09409465,-0.08016436,0.0125734545,-0.10163695,-0.010907887,0.018047104,-0.08408871,-0.0063016284,-0.07509887,0.061826423,0.018916631,0.076287255,0.023871174,-0.08368809,0.038754307,0.027330417,-0.043843534,-0.0204403,-0.11173872,-0.025590893,-0.061446995,0.08763997,-0.06842012,0.054884348,0.034947112,0.037869725,-0.018959736,0.08258366,0.036406543,0.04403087,0.019440316,-0.0025644181,0.033486392,-0.078050666,0.0062616733,-0.0326616,0.096072406,0.10387428,-0.021928845,-0.06399677,-0.08481132,-0.047332365,-0.019728351,0.021884229,0.058273677,0.0005886378,-0.02941756,-0.00808536,0.013463377,0.042314757,0.01292796,-0.08696988,0.022973979,-0.04695511,-0.07178802,0.032719664,0.012778023,-0.013652977,0.014072689,0.028674651,-0.025389872,0.0014810883,0.024027871,-0.015264748,0.06441683,0.016191103,-0.059652608,-0.05521126,-0.016645962,0.0041319774,0.0375712,0.062556885,-0.03350585,-0.011957808,-0.02240779,0.015853662,0.04931939,0.0046719825,0.0069166627,0.015600439,-0.049370136,0.036110587,0.018834276,-0.050436817,0.016191347,0.074582,-0.05255964,0.1131773,-0.03147248,0.056553602,-0.07038572,0.011488536,0.013402986,-0.015082183,0.007041878,-0.09879659,0.070756115,0.16943018,-0.023024721,-0.08803649,-0.03836474,0.025018955,-0.027875397,-0.00452865,-0.02254697,0.048330326,0.00053208764,0.025243793,-0.014423682,0.049410217,0.031275455,-0.00089088595,0.0140289655,-0.0075770305,0.071464844,-0.12864004,-1.4512617e-33,0.006512391,-0.034208562,0.06332956,0.039166566,0.016610976,0.027485732,0.011943484,0.025378676,-0.02259352,-0.041939747,-0.10777375,-0.07124711,-0.04888593,0.024284348,-0.04953995,0.01623902,-0.04342014,-0.01606154,-0.008925582,0.043039765,-0.046316147,0.07696811,-0.022856198,-0.072480865,0.008749855,0.057394948,0.02024675,0.03115519,0.04144345,-0.015582839,0.02198127,-0.051212482,-0.06920304,-0.025540281,0.049651265,0.018415982,0.08891784,-0.06000759,-0.0010448712,-0.0051981346,-0.021734858,0.030936865,0.03674797,0.009453425,0.018867265,-0.039270967,-0.027455585,-0.027761102,0.06538503,0.008273352,-0.011976669,-0.02802655,0.092500836,0.0010050789,-0.035235107,0.021788219,-0.03324771,0.07222588,0.060875278,0.026388321,0.077028394,0.10169106,-0.054933943,0.014368245,-0.041192647,-0.0013834684,-0.061935037,-0.0033400953,0.0068095606,0.066906795,-0.017097345,0.003901272,-0.012299232,0.019317681,0.025940223,-0.024817936,-0.04809817,-0.0142928725,-0.03839624,-0.039265912,0.043345418,0.02733212,0.060010746,0.055812925,-0.060750905,0.011325358,-0.03726711,-0.015604805,-0.03743647,0.0800984,-0.055880144,-0.060486782,-0.03610283,0.0407083,-0.024224874,-7.0628595e-34,0.10719509,-0.064440176,0.022542743,-0.085258305,-0.04803972,0.06142116,0.004295563,0.063344754,0.000105967636,-0.028325062,0.044353884,-0.008884428,0.071298964,-0.035691913,0.011859862,0.037453536,0.009847957,0.04670879,-0.010603014,-0.065589584,-0.09519232,0.0050605475,-0.06383234,-0.037839256,0.06273699,-0.017570334,0.014710491,0.06280595,-0.07403126,-0.048357546,0.027844768,-0.036748238,-0.037563022,-0.02075993,-0.032196004,0.014723292,-0.1054893,-0.038949996,0.016580066,-0.016292874,0.017729178,0.02768101,0.08455657,0.11880565,0.05561034,0.029825514,-0.07158107,-0.022043664,0.02499838,-0.028626472,-0.029190963,-0.103383936,-0.0005115314,0.04487265,0.06617807,-0.10453096,0.0057233833,0.047112636,0.03731677,-0.07170444,0.037432913,0.014636336,0.0033546244,0.0018868593,0.08749175,-0.0035160708,-0.101562396,-0.024108937,0.057943933,0.048547182,0.07922314,0.004053235,-0.040836632,0.044691507,-0.020139528,0.05851092,-0.12869601,-0.022785056,0.0026161913,0.011691131,-0.018706247,-0.041100305,0.051087905,0.02316035,0.033227853,-0.079197444,0.09785104,0.022455033,-0.052990437,0.09280252,0.02966534,-0.037458103,0.014699819,0.04621256,0.029231792,-2.1796208e-08,0.12282513,-0.05712881,0.0047925306,-0.0937451,-0.07045423,-0.018422715,0.053559806,-0.0066624205,0.019926222,0.00298988,-0.08627501,0.018041324,0.079330705,0.10323247,-0.05578545,0.0416337,0.033348743,0.04168789,0.060930043,-0.011778593,-0.14400384,0.026408648,-0.0420673,-0.02109489,0.024800282,-0.03522101,0.076236986,0.038229182,0.06808283,-0.071993396,-0.048256017,4.4661847e-05,-0.010990464,-0.038086962,0.04518179,0.09358448,-0.046919428,0.002811685,-0.017248528,-0.048709966,0.06964282,-0.038141243,-0.019310214,-0.03265226,0.018067596,-0.06785261,0.02573725,0.06702602,-0.01464567,-0.026947495,0.039986085,0.0033945478,-0.03165519,-0.020837823,-0.10438822,-0.09226781,-0.02415506,-0.038811922,-0.035205383,-0.050227072,0.032850586,0.057641264,0.11322073,0.06376529 +3.4.23.23,Isolated from the zygomycete fungi Mucor pusillus and M. miehei. The two species variants show 83% sequence identity and are immunologically crossreactive. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6,384,0.99999994,-0.04400747,-0.024712378,-0.051499795,-0.032438435,0.06409462,0.028619532,0.00054262363,0.0751117,0.009585771,-0.019796152,0.12342946,-0.09112176,0.05612509,0.051866993,-0.06526085,0.033651385,-0.014751909,-0.027872287,0.03874775,-0.026428547,0.07972085,0.057849728,0.074222185,0.042391736,-0.044321693,-0.053867605,0.0175874,0.05308546,0.012849091,-0.08100995,-0.02733525,-0.056182817,0.062463317,-0.013717874,0.05220257,-0.010248955,0.00448819,-0.010961468,0.10179123,0.026517423,-0.01303967,-0.008086008,0.0006328383,-0.025622409,-0.055266045,0.056846153,0.017264975,0.06921656,-0.0120521905,-0.017625377,-0.054132856,-0.041399688,0.013652959,0.0091528185,0.07971742,0.039981324,-0.024314484,-0.043682925,-0.00062854413,0.02955057,0.057758458,0.011280463,-0.017555702,-0.008750995,-0.06616617,-0.017855762,0.0038883376,-0.000110550485,0.01577467,-0.06297655,0.0052477424,-0.015699927,-0.023008894,0.01517535,-0.021024365,0.107365794,0.048780702,-0.0573578,-0.07911286,-0.025487725,-0.050109502,-0.00035812447,0.112714276,-0.04038053,-0.018011011,-0.061887644,0.021061571,0.080994636,-0.06387323,-0.039895844,0.06374554,-0.008517362,0.11204864,0.011643833,-0.048834752,0.067702636,0.058173347,0.0010223689,0.05255566,0.021341879,0.050872132,-0.030100958,0.08413583,-0.05904284,-0.0016589444,0.05281371,-0.03365739,-0.018477721,0.09678583,-0.016764289,-0.056610245,0.0030627847,-0.03573063,-0.024317613,0.0072989482,0.02392026,0.06976928,0.027503166,0.02929626,-0.026296573,0.029080978,0.04507771,-0.013184763,-0.03528579,-0.0005017113,0.12062219,-0.027285013,2.5691132e-33,0.016187007,-0.035723515,-0.035960987,0.0059862984,-0.02323199,0.063287444,0.015590961,0.03645531,-0.042593114,-0.05833384,-0.09060534,-0.0565132,-0.056306843,0.03602071,-0.13042969,0.019807106,-0.026375888,-0.040540084,0.0058883773,0.09980166,-0.0070949993,0.050800342,-0.041536387,-0.0069660437,0.059105482,0.04602602,0.03299007,-0.03211766,0.0347739,-0.02100696,-0.019553266,-0.05749323,-0.11530364,-0.044354316,0.0127468165,-0.02133888,-0.0076060556,-0.043551084,0.036464117,-0.018008986,-0.0041884943,0.013020915,-0.01954034,-0.059546832,0.0772944,0.043819,-0.046290915,-0.03925242,0.04992717,-0.038924918,0.014792355,0.0056717023,0.000570605,0.05110816,-0.05099287,-0.026884375,-0.024498694,0.048364274,0.08383757,-0.0055396175,0.054139953,0.05638586,-0.008714521,0.023978312,0.03444448,0.039447743,-0.11340664,0.019316673,-0.0009004913,0.06541267,0.008753493,-0.011962346,-0.062118165,-0.039413046,0.025312947,-0.14186907,-0.03536055,-0.06906219,-0.029044112,0.024464605,-0.028008541,0.07906841,0.049975142,0.018100329,-0.11105191,0.009612347,-0.0061246348,0.023148775,-0.05030729,0.016580647,-0.07577056,0.036268886,-0.05395996,0.046316136,-0.013224127,-2.9767976e-33,0.06492694,0.013466213,0.12142598,-0.030900672,-0.04697212,0.09125857,0.036692344,0.09087312,-0.015999068,-0.0528366,0.007884257,-0.027666174,0.028416615,-0.08668227,0.04357311,0.07617333,-0.05281277,0.09193308,0.0054647615,0.041918524,-0.044610538,0.042032935,-0.018876446,0.0006902489,0.032790776,-0.0089829145,0.029497677,0.025024088,0.017732508,-0.056396525,-0.034525137,0.028720962,-0.00013294851,-0.06792739,-0.10114301,-0.060583014,-0.042181462,-0.0038977307,-0.025081757,-0.008539109,-0.02875977,0.028385244,-0.023543518,0.12413306,-0.008554205,0.08959288,-0.04615158,-0.026052836,0.017094823,0.046838317,-0.016810717,-0.06435251,0.017723579,-0.0498941,0.05379297,-0.08890815,0.012573137,0.05413296,-0.0052710515,0.010629358,-0.016842818,0.038431562,-0.052232713,0.018966245,0.13464479,0.05981925,-0.04312329,0.026601305,0.077233106,-0.049141787,0.08571398,0.03801073,-0.015572487,-0.034961447,0.043109924,0.07732871,-0.11441801,-0.033836994,-0.017660739,0.021451555,0.059129376,-0.017922278,0.0728776,0.024306538,-0.033593323,-0.056760337,0.086412854,-0.02215244,-0.019880407,0.030316425,0.0037631493,0.061065495,0.0032944495,-0.008591593,0.044610765,-3.6375596e-08,0.12193842,-0.07797379,0.0072243316,-0.08348588,-0.10625803,-0.05874887,-0.018614544,-0.039949488,0.02040647,0.01736546,0.01997827,-0.025682699,0.017354839,0.13855687,0.022842098,0.0076788072,-0.047287747,-0.018846307,0.011489674,0.13975859,-0.06613261,0.020379951,-0.07390863,0.06527438,-0.01694664,-0.037175138,0.006709522,0.0027972162,0.053404655,-0.0096390555,-0.016140452,0.013282978,-0.025964329,-0.030863715,0.005789643,0.059759382,-0.06875687,-0.049962044,-0.03471032,-0.02191881,0.0707626,-0.09223192,0.0036892102,-0.06867317,-0.07685244,-0.1383457,-0.046050612,-0.025842145,0.055668786,-0.0033259746,-0.017650397,0.0076413536,-0.023089547,-0.06101378,-0.05173005,-0.048180606,0.017498197,-0.044796836,-0.0013675791,-0.099721126,0.022765389,-0.08181664,0.09116929,0.0077629946 +3.4.23.24,"This endopeptidase from the imperfect yeast Candida albicans is inhibited by pepstatin, but not by methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenoxy)propane. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6",384,1.0,-0.00085557305,-0.0066378186,-0.09380573,-0.010516599,0.066207856,0.08838016,-0.020600796,0.07265798,0.022967996,0.04248534,0.07247556,-0.035407487,-0.07626666,0.041410003,-0.04953062,0.011121036,-0.008362855,-0.055472963,0.02008873,-0.012850156,0.08164261,0.043407258,0.07615396,0.06270676,-0.03283165,0.010213087,-0.0077775046,-0.022805734,0.02418668,-0.08400015,0.05227348,-0.057078,0.06152284,-0.041195855,0.038932025,-0.02161761,0.003921331,0.028040994,0.07198949,0.04395451,0.037264418,-0.011992313,-0.09298979,0.032270703,0.043790065,0.018565604,0.029152287,0.10360259,0.017120535,0.021152053,-0.035412796,-0.059925105,-0.003510102,-0.060830493,0.0708913,0.04161112,-0.0026291138,-0.031102419,0.05363954,0.027582472,0.089990996,-0.02037824,-0.05199903,-0.0018511263,-0.031488582,-0.061833307,0.047258057,-0.035666104,0.064426556,-0.028647164,-0.002070326,-0.10040628,-0.03488135,0.016979834,0.028474526,0.13424428,0.03075173,-0.113373116,-0.11160269,-0.02953663,0.011433328,-0.05939145,0.08577614,0.024923773,0.050873067,-0.040302936,-0.003917417,0.06147114,0.040864974,-0.01036817,0.024398768,-0.03524851,0.06264823,0.02012423,0.0051405053,-0.021880487,-0.011951305,-0.04510152,-0.017124373,0.013435991,0.02760764,-0.028996507,-0.08108345,-0.06885802,0.032135785,0.085513115,0.028762445,0.040254105,0.0884098,-0.004580256,0.01141263,-0.030610727,-0.0008835994,-0.0553542,-0.009547792,0.010452784,0.035413373,-0.009533241,-0.008768371,-0.015071648,0.0144985765,0.036451574,0.02923355,0.0013047955,-0.09400288,0.024787854,-0.0061186883,3.415863e-33,-0.034835782,0.02717876,-0.058973897,-0.017650103,0.054987047,0.102289125,-0.031231662,0.0056138104,0.006145486,-0.07642578,-0.062521555,-0.044915073,-0.029763881,0.06518745,-0.07003339,0.025883779,-0.035184544,0.009008303,0.02852819,0.009642888,-0.009161962,0.01656647,-0.08735439,-0.05680084,0.05411625,0.060052782,-0.0029278027,0.05637103,0.09914304,-0.03393726,-0.014909878,-0.03546966,-0.05518748,-0.012111619,0.016593138,-0.0017216593,0.066523336,-0.06093481,-0.008609036,0.039690267,-0.069553375,0.042689677,-0.0078058974,-0.015216572,0.0013762227,-0.08749702,-0.043140296,0.097864345,-0.0007948749,0.016480071,0.019766692,-0.031102045,0.04906252,0.0023119485,-0.05674623,0.02954045,-0.036201373,0.052331302,0.08086853,0.012577389,0.03565696,0.06026712,-0.022228483,-0.034469612,-0.037039276,0.035325017,-0.034844417,0.009807896,0.008296623,0.024447685,-0.06463582,0.06737491,0.052462343,0.020260595,0.026509887,-0.09919924,-0.100402705,0.036851577,0.03296796,0.03521592,0.046511322,0.0028386277,0.030184124,0.012973082,-0.05474565,0.021671811,-0.022774482,-0.021557458,-0.06739685,0.038734127,-0.018066593,-0.042370465,-0.005358194,0.11191663,-0.0043478957,-3.590205e-33,0.07594354,-0.04824183,0.04880884,-0.06209315,-0.04062796,0.07624086,0.04437662,-0.036146574,-0.039327297,-0.10795739,0.11665335,-0.09910752,0.107471235,-0.03527165,-0.010267056,0.0029887399,-0.02634445,0.029498726,-0.022862788,-0.0042721056,-0.03220739,-0.0348118,-0.029852789,0.0648181,0.08811363,-2.5638927e-05,-0.008648784,0.043349568,0.007072123,0.010332642,0.01333653,0.00627543,-0.04868371,-0.078356266,-0.059188455,0.11325546,-0.12148406,0.016809735,-0.034433067,-0.011662178,0.027416896,0.0014591191,-0.0116860885,0.10275499,-0.014897404,0.097727336,-0.026888546,0.000340457,0.028943477,-0.021880498,-0.002428295,-0.024996646,-0.057605766,0.06665194,0.077990554,-0.017859856,0.022605874,0.0037306098,0.0036384952,-0.0442649,-0.020856595,-0.011231065,0.05134584,-0.017099675,0.09286653,-0.0025277697,-0.113644265,0.054549005,0.11797682,-0.024417551,0.12296318,-0.011730429,0.014892936,0.043460995,-0.0958464,0.070928805,-0.00716813,-0.08217376,-0.016819574,-0.06467321,0.0185698,-0.03336249,0.035060316,-0.020187238,-0.016650043,-0.037133623,0.014045417,0.035453115,-0.049712174,0.11849563,-0.021206122,0.014605577,0.0038016515,0.02577365,0.026686043,-3.9954926e-08,0.10643033,-0.031397488,0.10515321,-0.078488834,-0.095993504,-0.0220516,0.056862026,-0.023926545,0.0054663313,-0.07680384,-0.007123155,0.0364214,0.0006535695,0.06434271,-0.026629142,0.014917165,-0.0075367745,0.069757,0.032875065,-0.028226888,-0.13985938,0.013307495,-0.06903398,-0.07893141,-0.0061005517,-0.06198777,0.0026429002,0.032423347,0.033631463,-0.050970305,0.0052273665,-0.02833122,-0.041517776,-0.05189151,0.0043384153,0.09419077,-0.022607537,0.026159735,-0.060619414,-0.05098657,0.022838673,-0.053810235,-0.036235865,-0.025149971,-0.0046331557,-0.08712214,0.087131314,0.040018644,-0.030642519,-0.027572628,0.04705897,-0.035742696,-0.03133038,-0.054061893,-0.08601699,-0.022569455,-0.049804576,-0.032548614,-0.021522475,-0.066852786,-0.008250806,-0.054199558,0.1454683,0.0025327795 +3.4.23.25,Located in the vacuole of the baker's yeast (Saccharomyces cerevisiae) cell. In peptidase family A1 (pepsin A family).,384,1.0,-0.008504071,-0.004573885,-0.11896633,-0.05217491,0.00076356716,0.048726104,0.00810426,0.028162079,0.09911022,-0.04528203,0.09557649,-0.04456001,-0.08191047,-0.040523127,-0.08909776,-0.0639926,0.01683192,-0.03994941,-0.0054202843,-0.08172215,0.08631079,0.0045957337,0.113561265,0.036330868,-0.045643512,-0.017991522,-0.017249595,0.03276725,0.032995574,-0.099712126,-0.0013418379,-0.037268072,0.09346283,0.0319379,0.07041997,0.016052034,0.043420855,0.014007564,0.15635017,-0.011248674,0.03925299,0.0017892164,-0.026400823,0.012358933,0.0021722731,0.09980735,0.040061664,0.0073280805,0.05196995,-0.017396083,0.0060144896,-0.058050983,0.057433166,0.014812748,-0.008075027,0.10720468,-0.014326601,-0.0570182,0.079828255,0.017422918,0.021320978,0.011526268,-0.008298292,0.03713136,-0.05782819,-0.06337646,0.10283685,0.026310418,-0.023695512,-0.06526582,0.021142341,-0.0062269634,-0.032570366,-0.010715006,-0.0027362122,0.055359308,0.069435954,-0.07476907,-0.03505485,-0.0026997584,0.040380623,0.02361011,0.0812136,0.11106649,-0.02822747,-0.053198818,0.012075769,-0.013376824,0.061833378,-0.061919414,-0.02379382,-0.041958038,0.028718034,0.027560066,-0.067756556,0.031097427,0.018568464,-0.01273781,0.08190962,0.012534296,0.035991333,-0.0130172465,0.07348392,0.0027183653,-0.005407629,0.07142535,-0.0719438,0.10016961,0.07292703,0.02072794,-0.012423678,0.0245221,0.022785595,-0.026047576,-0.013471107,-0.018278884,0.030761551,0.0047637313,0.03131352,-0.050022494,-0.04327868,0.0657418,-0.01780479,0.015680255,-0.07502816,0.02051767,-0.09116175,-7.632917e-34,-0.031366006,-0.0022986399,0.055813495,0.021893118,0.0063775843,0.049587954,-0.006423383,0.0056194626,-0.043965835,-0.06291009,-0.04760738,-0.07540518,-0.055944234,0.073608406,-0.09043138,0.004513635,-0.032951366,-0.051821914,-0.017173596,-0.0056752376,-0.09236166,0.028912371,-0.055178802,-0.060724705,0.013845439,0.009646328,-0.019606732,-0.005323302,0.0013561128,-0.019236617,0.0047543836,0.011190136,-0.010778343,-0.01475837,0.051750794,0.04159345,0.058155376,-0.020655306,-0.035856526,0.050720956,0.049228515,0.059488736,0.036988094,-0.020302229,0.009538455,-6.211023e-05,-0.024739368,0.036203932,0.10144848,0.015697563,-0.035160888,-0.010415439,0.08804611,-0.022113476,0.00639024,0.01892603,-0.029805083,0.013112601,0.043236166,0.03160209,0.031489957,0.08891352,-0.05443941,0.06266684,-0.0076720393,0.0063253413,-0.11256889,-0.06693369,0.03209489,0.04612552,-0.052350495,0.019323705,0.06401441,-0.021153502,-0.014946661,-0.05904006,-0.103179276,-0.00022772694,-0.06812661,0.009889245,-0.008944826,-0.04822481,-0.021005146,0.007652946,-0.06635115,-0.024723645,-0.014556818,-0.04799078,-0.06197396,-0.029231094,-0.07981424,-0.051304195,0.040783305,0.019527722,-0.030897258,-2.7439276e-33,0.084943295,-0.05488653,0.09631115,-0.049299415,-0.07749196,0.07648809,0.048318658,-8.103787e-05,-0.063622735,0.0011629125,-0.033980086,0.028973963,0.055329237,-0.043179333,0.028254995,0.10483644,-0.009139194,0.058037076,-0.075186454,-0.035357215,-0.06477911,0.029941458,0.00027620755,0.06165888,0.016633175,-0.01920498,0.041073058,0.04512652,-0.011015833,-0.053041313,-0.09408366,-0.052470155,-0.038575284,0.01541387,-0.02315726,0.003859865,-0.0746853,-0.043428022,-0.031868953,-0.007283994,-0.008705545,0.084140316,-0.071632035,0.0951048,0.0152878165,0.15012848,-0.02556561,0.014554698,-0.0072706374,-0.013419427,-0.04863713,-0.059884433,-0.00508434,0.063456774,0.066085376,0.028511843,-0.03114299,0.05194529,0.02485225,-0.04250556,-0.0066642524,7.031515e-05,0.012860861,0.009747119,0.0039720675,0.040739153,-0.09921619,0.03429897,0.043251935,-0.0071356082,0.057969272,0.064045385,0.0020930846,-0.0055013406,-0.099628314,0.09971226,-0.048788104,-0.09985747,-0.05116865,-0.02689397,-0.019291492,-0.030181259,-0.026142916,-0.00010342186,0.014928138,-0.031258434,0.06986529,0.018145993,-0.0045382627,-0.0007916483,0.0063900496,-0.009638176,-0.015925292,-0.02270044,0.009991288,-2.6365266e-08,0.11272279,-0.025346408,0.041103877,-0.070787735,-0.038525384,0.014418418,0.10009278,0.027598808,-4.2062297e-06,0.06616875,-0.06286479,0.034881447,0.0006026045,0.05718266,0.03585884,0.081047125,-0.069674976,0.049572553,0.018096892,0.05378143,-0.07671486,0.016943028,-0.022055166,0.027648907,-0.05468083,-0.085839786,0.05229855,-0.025032977,-0.011957483,-0.049791545,0.016955167,0.037785523,-0.010711538,-0.07985616,0.018023865,0.07507648,-0.08051172,-0.04408399,-0.08573763,-0.026519407,0.021510629,-0.09523073,-0.0012952287,-0.03486541,-0.019371448,-0.036567416,0.033981837,0.11109916,-0.054888878,0.035411987,-0.049650457,0.056718316,-0.05729082,-0.011619783,-0.1326709,-0.030927906,-0.06434308,-0.10357592,-0.023507105,-0.053431775,0.0038404723,0.012370856,0.1188357,-0.063957155 +3.4.23.26,"From the imperfect yeast Rhodotorula glutinis. Somewhat similar enzymes have been isolated from the imperfect yeast-like organism Cladosporium sp. [4,6] and the imperfect fungus Paecilomyces varioti [1,2].",384,1.0,-0.08537584,-0.027394496,-0.07444293,-0.03781416,-0.007111961,0.005238332,-0.067921594,0.021018349,0.023565719,-0.017643383,0.05787079,-0.0060533234,-0.052464284,0.04171839,-0.09603617,-0.05177323,0.0024120642,0.0023809148,0.013969402,-0.0669852,0.045257114,0.10012251,-0.023207348,-0.041494202,0.05848547,-0.036068458,0.026354015,-0.06499755,-0.0039599068,-0.13504964,-0.036349557,-0.04564086,0.005902727,-0.041931108,0.06894512,0.09404162,-0.005758577,-0.007831399,0.09849261,0.021616962,-0.023382263,-0.07753575,-0.011861736,0.0005697437,-0.12096301,0.05184772,-0.007875233,0.059562016,0.07545774,-0.027936053,-0.07728472,-0.045858033,0.04411343,-0.036325876,0.0873412,0.06913285,-0.0013150547,0.006716945,-0.048330627,0.016557708,0.042639125,-0.0029847221,0.021908905,0.032588318,-0.06834964,0.019805865,0.06848917,-0.011864659,0.06721665,-0.01412293,-0.008047362,-0.005165731,-0.08232499,0.017078431,-0.017355084,0.081430785,-0.008822958,-0.06621223,0.02058766,0.03736407,0.016857693,0.06248946,0.049676944,-0.003768959,0.002034644,-0.064817995,0.045704443,0.05042215,0.048401404,-0.025148809,0.019766364,0.029904185,-0.006583809,-0.043607924,-0.01777852,0.053956077,0.018423002,0.039964054,0.04266651,-0.044873156,-0.0024633007,-0.057974417,0.024304256,-0.05646851,-0.033780504,0.033865206,-0.018556593,0.011132209,0.089538895,-0.014473432,-0.007684364,0.036094986,-0.0021337483,-0.025876194,0.027036084,-0.042906128,0.07378885,-0.016359111,-0.091363095,0.00022348134,-0.014837682,0.029163914,0.032721493,0.009828686,-0.07349351,0.038951237,-0.05163754,1.4988188e-33,0.058087073,0.021900892,-0.034619857,-0.010110706,0.029718807,-0.0076056463,-0.014105365,0.019778753,-0.041469585,-0.05613872,-0.09698654,-0.046518143,-0.11283024,0.10242887,-0.052141912,0.01686911,0.0925772,-0.007989006,0.00086789194,-0.01606416,0.050554004,0.09680913,-0.0507405,-0.027015738,0.026912734,0.026668103,0.019427892,-0.023319608,0.012150609,-0.029396757,0.019292798,-0.09704544,-0.00014153434,0.112652235,0.0099960435,0.0012274534,0.021676015,-0.028722093,0.01908849,-0.016164906,0.012774794,0.07259714,-0.026225135,-0.04286865,0.06452892,-0.013277848,-0.06698984,0.0147013925,0.031605463,0.0824472,-0.028998852,0.03735944,0.074943796,0.005773799,-0.052241627,-0.02694357,-0.030800553,0.056197636,0.08466402,0.021542149,0.013104103,0.15604685,-0.02645564,0.022607138,0.03060163,0.01035029,-0.010519557,-0.06433083,-0.055768054,0.052070625,-0.04742841,-0.021421725,-0.082442924,-0.031932406,0.05326443,-0.121758245,-0.06264615,-0.081723385,-0.05545686,-0.025738869,-0.011570231,-0.040367015,0.015096747,-0.020233685,-0.11924533,-0.0021716058,0.010991068,0.03188806,-0.0031993468,0.030873543,0.04177515,-0.058881007,-0.0062661576,0.035767402,0.022292025,-2.8801121e-33,0.1640558,-0.09641208,0.12530823,-0.023693599,-0.07042525,0.12624471,0.0153756,-0.015895367,-0.06913902,-0.03340976,0.04769158,-0.005988558,0.006569854,-0.0048362026,-0.0143852085,0.032471117,0.0062835244,0.104565956,0.011473154,0.036786,-0.0060591586,0.016700568,-0.025778135,-0.030225387,0.11165256,-0.0043650344,0.012507906,0.11618966,-0.122322574,-0.015226656,-0.033224884,0.056260966,-0.040667545,-0.09981369,-0.03207616,0.040165875,-0.031161835,-0.0011037466,0.016840007,-0.018121613,0.048161115,0.008902527,-0.007396242,0.058139678,0.028859623,0.020933643,-0.08456462,-0.043671474,-0.01883587,-0.03537923,0.018815828,0.058798727,0.008304266,-0.02473482,0.039504018,-7.805954e-05,-0.026515692,0.046312343,0.007553166,-0.006968263,-0.05127983,-0.060032073,-0.053405076,0.05196436,0.10570185,0.10703926,-0.0025772506,0.015170025,-0.010324743,0.0053186305,0.064633474,-0.0073760594,0.009833207,0.009615232,0.012862739,0.02378161,-0.07079332,-0.020463109,-0.025146525,0.008025947,0.07725262,-0.0669558,0.08210278,-0.083411016,0.03788144,-0.021974778,0.04945565,0.0062327413,-0.01538992,0.10150852,-0.025036547,-0.01612977,-0.046428706,-0.0057715005,0.07986299,-3.5501714e-08,0.09038252,0.016076656,0.031282652,-0.06941669,0.028583419,-0.05251891,0.040453106,-0.005858123,0.017947862,0.020232152,-0.11104317,0.05106397,0.018925143,0.012884493,0.08386485,0.022199474,-0.07607825,0.024695262,0.015272324,0.08606116,7.434709e-05,0.032832097,-0.104993634,0.024196206,-0.015219427,0.014479253,0.056163445,0.019153647,0.028601173,-0.025037196,0.0155861825,0.041724354,0.029912692,-0.044352714,-0.055038348,0.012979025,-0.076925956,-0.0036288663,-0.092173375,-0.06754155,-0.01864287,-0.062443838,0.025503376,-0.03327823,-0.0433563,-0.04796795,0.04290318,-0.033178657,0.03636925,-0.046675526,0.047889266,0.02822644,-0.0359363,-0.021774191,-0.10407052,-0.03236838,0.060136862,-0.011861925,-0.06876246,-0.10186905,-0.015473766,-0.033946104,0.11680533,-0.021742783 +3.4.23.28,From the imperfect fungus Acrocylindrium sp. Has a very low pH optimum on casein of 2.0. In peptidase family A1 (pepsin A family).,384,1.0,-0.0041616717,-0.027112553,-0.07578137,-0.072340615,0.03983637,-0.015832666,-0.0007328332,0.13331783,0.033212494,-0.0172622,0.113935284,-0.015228077,-0.0190887,0.06921909,-0.0703059,-0.060977243,0.02149967,-0.029846236,-0.053316884,-0.07151859,0.03218084,0.015489885,0.039896265,0.026096866,-0.12396587,-0.018898576,0.010509397,-0.00516896,0.026105989,-0.12692611,0.006309629,0.047846653,0.04622854,-0.06248873,0.04586953,0.017001592,-0.01996915,-0.05471715,0.116111904,0.05804875,0.046010047,0.020608015,0.03794834,0.0141764935,-0.034561526,-0.021341832,-0.00097636017,0.0842578,0.06542008,-0.03207456,-0.089704506,-0.007871368,0.011708789,-0.04226152,0.0063857525,0.066503555,-0.010488561,0.017421054,0.038486134,-0.003330635,0.045840867,-0.013330353,0.026950447,0.008630271,-0.06029219,-0.024143651,0.03371275,-0.080245346,-0.0075629526,0.057187688,-0.00023999065,0.025198895,0.0074535124,0.021836707,-0.003665656,0.08645312,0.0024449779,-0.11753126,-0.09571919,0.040462364,0.013044929,-0.056399714,-0.068453714,-0.018253023,-0.012765332,-0.066824235,0.0792767,-0.056592185,-0.018801311,-0.032012526,0.11706371,0.042654544,0.06002548,-0.011739475,-0.10202184,0.06429618,0.09467612,-0.038341336,0.025939478,0.021873679,0.007039471,-0.026146423,0.0057553975,-0.06569907,-0.014105108,0.0020491432,-0.052930597,0.04358823,0.10401058,0.06426802,-0.013262672,-0.029202756,0.02830588,-0.06510445,-0.026498191,-0.030705698,0.06709925,0.0043080356,-0.01549969,-0.0043835207,0.037810978,-0.007622968,-0.025366152,0.011978276,-0.0077331862,0.046114795,-0.07956501,1.6818294e-33,0.032908987,-0.012330126,0.03929123,-0.029626397,0.0473529,-0.017454496,-0.09430818,0.008534613,0.041864943,-0.055166807,-0.046763387,-0.030891685,-0.11282003,-0.010382739,-0.07550736,-0.003445751,-0.019094905,-0.075667016,-0.04846024,0.060237583,0.01680066,0.01662869,-0.06644048,0.006843402,0.027340302,0.04466066,0.07562047,-0.012209399,0.046346284,-0.012953929,0.049008083,-0.029206537,-0.1081633,0.051472966,0.015956257,-0.0146209635,0.0012516596,0.008728373,0.050767004,0.028431894,-0.045318,0.050227545,0.110771686,-0.0026041807,0.08539965,-0.03748361,-0.04981032,0.05805176,0.03425374,0.040496323,0.013501969,-0.013565741,0.057875704,0.04124753,-0.040654134,-0.056654878,-0.041615833,0.0004896658,0.054098994,0.018677916,0.055480517,0.077853724,-0.027063353,0.014739765,-0.08365435,0.015550371,-0.085346185,-0.05837782,0.057141043,-0.016865762,0.009846139,0.050507266,0.02739674,0.029900536,0.040598866,-0.05189142,0.007886058,0.0066603636,-0.021073187,0.0051004887,-0.04297515,0.029584354,0.016109647,0.01759277,-0.107035466,-0.042822056,-0.056569003,0.04115408,-0.040221497,-0.013084268,-0.015443137,-0.04930736,-0.038845904,0.03671592,0.019256601,-2.8116234e-33,0.07865231,-0.09863607,0.11568662,0.04256308,-0.026440348,0.0145906955,0.020583116,0.06844974,0.010843577,-0.092112705,0.018807847,0.02551411,0.02504671,-0.030031832,0.050992884,0.1305245,0.008037619,0.02861201,0.0073412824,0.0136942845,-0.084727935,0.026579846,-0.045848574,0.08434292,0.06247596,0.044766393,-0.039728086,-0.0046365093,-0.014728117,0.0142780505,-0.04286833,-0.015722606,-0.07832393,-0.045004092,-0.09039883,-0.020655984,-0.049844325,-0.054951057,-0.037268184,0.05280739,-0.0046791807,-0.02857653,-0.01047893,0.088209406,0.03366833,0.067978784,0.05723668,-0.07459378,0.07986429,-0.02363534,-0.0049855714,-0.01587652,0.02615557,0.035442285,0.068429746,-0.008510709,-0.003926077,0.054451153,-0.025496151,0.009213316,0.041528936,0.01512719,-0.050906904,0.015416653,-0.059267554,0.037845492,-0.06569078,0.045589413,0.10123081,-0.051869627,0.06202594,0.02901141,0.07204514,-0.02392376,-0.00612863,0.052473947,-0.034181576,-0.034392506,-0.041261815,0.041222468,-0.047125433,0.018326532,-0.064118,-0.016425848,-0.007356893,-0.011168221,0.05429688,-0.059340354,-0.103918165,0.05170991,-0.015479051,0.031901293,0.041201655,0.009663941,0.056345377,-3.095402e-08,0.08938584,-0.047732692,0.07259214,-0.09218377,0.023464462,-0.028200813,0.015851954,-0.00016123992,0.030031802,-0.03150603,-0.09348133,0.07803911,-0.034066476,0.073759854,0.006345881,0.08615996,-0.05361525,0.013363585,0.0030510898,0.054202154,-0.12208233,0.03217188,-0.1018756,-0.034184873,-0.055502445,0.033000454,0.08754275,-0.07493026,-0.052259468,0.029835714,0.005427146,-0.00045960819,-0.0050228657,-0.05967918,0.028218636,0.053120032,-0.038369626,-0.03725769,-0.087055355,-0.06371825,0.0059037553,-0.08098465,-0.048197117,-0.04621926,-0.020128557,-0.087247886,0.018970292,0.058693293,0.021414803,-0.022019934,0.06165995,0.01015685,-0.07633235,-0.06863802,-0.04898182,-0.022549726,0.08826696,-0.044960067,-0.06270974,-0.062809244,0.01793237,0.02654737,0.1078122,0.019325646 +3.4.23.29,From the basidiomycete Polyporus tulipiferae (formerly Irpex lacteus). In peptidase family A1 (pepsin A family),384,0.99999994,0.02807365,-0.047500286,-0.07617238,0.02529203,-0.012108837,0.029979931,0.058183953,0.032597627,0.045876592,-0.00011743702,0.08980611,-0.055704504,-0.057475224,-0.010840945,-0.076674625,0.014830741,0.0035430593,-0.0041773487,-0.0030356531,-0.037886508,0.13347866,-0.05201339,0.04213142,0.09381179,-0.007998247,-0.016414134,-0.0072588585,-0.043954827,-0.032903966,-0.07750733,-0.037770636,0.004196802,0.1190957,0.00841066,0.097159795,0.014541487,0.02759713,-0.03282965,0.08660048,0.019175384,0.052108523,-0.021230562,0.06788065,-0.033292133,-0.031175409,0.065780625,-0.008011197,0.0997299,0.10115433,-0.018681142,-0.08360296,-0.060872376,-0.00894572,-0.06429322,0.02152818,0.046996806,0.049264714,-0.08311414,0.033119082,0.022037236,0.039781712,0.013620558,-0.033533726,0.024129558,-0.12585631,-0.01550871,0.03167976,-0.015640726,0.015111181,-0.040486585,-0.0032180531,0.010425092,-0.08019943,0.030828612,-0.07531154,0.05686364,0.081269585,-0.02117657,-0.09090513,-0.037598047,0.016826563,0.012087506,0.041190937,-0.017190259,-0.026137223,-0.03468073,0.0882288,0.011060506,-0.0067396443,-0.039773665,-0.056155678,-0.011450905,0.079510435,-0.049247663,-0.106391266,0.0016050029,0.020947006,-0.04190603,0.061668456,-0.0086005945,0.02982737,-0.049461737,0.05206311,-0.03584861,-0.08834865,-0.020714765,-0.094892554,0.06250144,0.12638587,0.024952283,-0.114226,-0.012345447,0.020058896,0.050392482,-0.032676153,0.054630186,0.0028078214,-0.021275794,0.038128786,-0.042558666,-0.02675438,0.0067869993,0.007016891,-0.015705029,0.02351552,0.08358104,-0.10997926,2.292484e-33,0.036789156,0.0327486,0.06742319,-0.0037670645,-0.0040628533,-0.019714892,-0.022053044,-0.005379062,-0.04120393,-0.050656024,-0.08926428,-0.0543687,-0.0091759525,0.02281788,-0.0052451845,0.06072553,-0.054840937,-0.014660184,0.012024222,0.058759224,-0.120632246,0.12578815,-0.017034132,-0.038418736,-0.015707364,0.0019587998,0.04293789,-0.03315506,-0.004441889,-0.0065724705,0.06740996,-0.06542387,-0.07540539,0.025037812,0.02114482,-0.020555243,0.02291486,-0.13359582,0.00850198,0.07434452,0.013640497,0.036692657,0.099169195,-0.008395934,0.03656983,-0.0021363988,-0.027959662,0.0025187547,0.028968632,0.04499476,-0.016208047,0.040308557,0.06767836,0.026721517,-0.06992804,0.010226237,-0.00039991035,0.045476653,0.053964496,0.02573742,0.12810214,0.05258708,-0.046248645,-0.032329727,-0.0011974478,0.053871375,-0.070512876,0.048562884,0.0135560995,-0.044868108,-0.031814143,-0.0333664,-0.007365388,-0.031442296,0.061161075,-0.047222722,-0.016657524,-0.045626994,-0.037678774,-0.0055931094,-0.012750319,0.016382921,0.0801692,0.009935098,-0.06550733,-0.043739606,-0.014094851,0.07041465,-0.039580036,0.0105894655,-0.07785736,-0.05071278,-0.076622486,0.013782058,-0.008310648,-2.5876633e-33,0.027827233,-0.04514818,0.042254042,-0.04663427,-0.029736103,-0.009087041,-0.004824145,0.08772339,0.017362146,-0.08553745,0.033714954,-0.025090577,0.08224752,-0.061376724,0.019746311,0.026700025,0.015639957,0.023165034,-0.03934878,-0.02549715,-0.09313056,0.042281073,0.0041646594,-0.0029351856,0.030333739,-0.0009943387,0.037666623,0.054043464,-0.06316963,-0.047374267,-0.021201849,0.0034015616,-0.034301724,-0.016759994,-0.033829406,-0.045714792,-0.06560778,-0.06432684,0.016393036,0.04148823,-0.041236483,0.04167467,0.056260813,0.07591425,0.063613795,0.024514021,-0.05747416,-0.01725186,0.018748645,0.0426699,0.047379233,-0.052847404,0.07182993,0.021220298,0.061531574,-0.078317925,-0.00059155276,0.08452656,-0.0043883487,-0.03223916,-0.0067561897,0.06544932,0.022745904,0.03269192,0.069004,0.05528052,-0.14666961,0.0026539802,0.013544854,-0.044299807,0.067580976,0.009593756,-0.08243197,0.05764144,-0.01083787,0.07525241,-0.13633609,-0.038926773,-0.043751534,0.010290277,-0.018919433,-0.041398868,0.031860836,0.05184273,0.022292092,-0.01260985,0.056692902,0.0007405898,0.03109474,0.030711155,0.020765657,-0.012954565,0.033175845,0.092404984,0.04666803,-2.8134487e-08,0.09193257,0.010913743,0.0005836275,-0.011903517,-0.056046594,-0.0626223,0.06481647,-0.026295166,-0.036684837,-0.019992597,-0.0422665,0.050429445,0.033669863,0.07501986,0.03236559,0.023249412,0.028542649,0.0043607624,0.01687365,0.06508398,-0.060122173,-0.04289377,-0.064607784,0.06309559,-0.044002313,-0.047097974,0.09521841,-0.035992876,0.08830595,-0.038434893,-0.028247593,0.0147491675,-0.042137437,-0.06857315,0.059647013,0.069056734,-0.067468576,-0.05938976,0.007001878,-0.022785949,0.061450996,-0.07280291,-0.0030503925,-0.050608758,-0.004916218,-0.010535635,0.0016364075,-0.011365004,-0.009397236,-0.022264497,-0.040383253,0.022021573,-0.051323097,-0.017744081,-0.08004715,-0.08808602,0.015358884,-0.071421735,0.05183878,-0.02327445,0.029106682,0.010305336,0.16766104,0.049923982 +3.4.23.30,"From the basidiomycete Pycnoporus sanguineus, formerly known as P. coccineus and Trametes sanguinea. Formerly included in EC 3.4.23.6",384,0.99999994,-0.010674161,-0.0041103554,-0.063890494,0.027644416,-0.051594317,-0.038227342,0.021143187,-0.026917512,0.0007693511,0.006633954,0.090388976,-0.10469821,-0.020187873,0.024631968,-0.06902582,-0.01042221,0.03259427,-0.008663836,0.07671579,-0.0029951679,0.044342417,0.04061269,0.054228354,0.045816887,0.024181705,0.01371813,-0.035389204,-0.042417143,-0.061376702,-0.050847657,-0.05027501,0.027881345,0.08931609,-0.027589595,0.07141743,0.019418936,-0.05767411,-0.05535897,0.0850553,0.098671235,0.069109775,0.028495725,0.014551008,0.046716027,-0.07498449,0.067758724,-0.057944473,0.040469788,0.04748921,-0.047583655,-0.055939976,-0.08047126,-0.03861273,0.018072726,-0.020728594,-0.000347593,0.047941748,0.011276052,0.038563058,-0.0074186893,0.0329565,0.031525113,0.02990779,-0.019645454,0.0036388289,0.0146544175,-0.086322114,-0.075852096,0.018332446,-0.014092937,-0.013146065,-0.0054373257,-0.02028727,0.0067279506,-0.032959804,0.04453314,-0.012939285,0.008265662,-0.051986657,-0.11335773,0.010327977,-0.019478135,-0.10320729,-0.025147552,0.01920033,-0.0027111194,0.034298517,-0.005757192,-0.04671729,-0.04566097,0.05713113,-0.035281405,-0.02080384,-0.03511898,-0.06931542,0.036352653,0.010340742,0.101262316,0.035994057,-0.03321802,-0.016326211,-0.045672208,0.0072856727,-0.0020099715,-0.07438189,-0.060256973,0.004666408,0.008685585,0.10845692,0.013301612,-0.12585823,-0.01171366,-0.060136203,-0.011132591,-0.039475214,0.016591024,-0.019770352,0.025459122,0.06503478,-0.04307493,0.06807565,0.017396085,0.01554919,-0.030447084,0.008541158,0.065111786,-0.06604344,4.8864136e-33,0.0685327,0.00046547904,0.061089057,-0.012997084,0.007439018,-0.023608997,-0.09196207,-0.039764754,-0.037872087,-0.10065769,-0.13188069,-0.051495664,0.0011290817,0.066751674,-0.0066702655,0.04494025,-0.03605542,-0.050327055,0.08038134,0.020393167,0.018621389,0.11154189,-0.0009954388,0.023800306,0.02244161,0.0077517056,-0.03991267,-0.05643438,0.018984219,0.047617536,0.041466575,-0.037927568,-0.017787613,-0.04269562,-0.004022078,0.020425476,-0.046338793,-0.16461752,-0.11055323,0.035142902,0.022478485,-0.038761213,0.061440047,0.003845668,-0.001550144,-0.043691196,-0.05165714,0.07158759,0.060504746,0.02241142,-0.020180918,0.03422323,0.09460193,0.011345028,0.02432309,-0.013278267,0.04795261,0.03268044,0.016960261,0.002446614,0.14612919,0.081232555,0.02641219,-0.050328314,0.07151126,0.10594612,-0.008166295,0.066857345,0.01318145,-0.08992399,-0.0616878,-0.062400028,-0.023654025,0.083919115,-0.019499306,0.00050778064,0.032350667,-0.07519706,-0.038287345,-0.06539019,-0.0539329,-0.044770714,0.07488304,0.024812384,-0.024855986,0.034121778,0.018810255,-0.010203413,-0.021169469,0.031296223,-0.07608298,0.03702657,-0.06499579,0.012763052,-0.061468594,-4.613227e-33,0.049091253,0.036473192,-0.0030869404,-0.020052208,-0.04702658,-0.022012865,-0.082630195,0.04849046,-0.05841728,-0.03907744,0.0030060858,-0.08507077,0.06528771,-0.1296502,0.07876282,0.08323647,-0.0035902464,0.027078614,-0.025226738,-0.007190481,-0.024800962,0.028331423,0.036212906,-0.025112696,0.017014047,0.0049161976,0.14051208,0.05242674,-0.0823082,-0.05451109,-0.056099176,0.017754208,-0.045514014,-0.034363832,-0.05120501,0.02687991,0.017883388,-0.026381595,0.051097035,-0.014709147,0.009126244,0.048015255,0.05171057,0.076132365,0.05632568,-0.00506263,-0.034641583,0.10504303,0.012295878,0.023117594,0.04028412,-0.036848754,0.030640304,-0.041437294,0.07006827,-0.109266244,-0.06074794,0.026695937,0.04415077,-0.06671886,-0.012338553,0.01843611,-0.01178862,0.040703487,0.0699185,0.045629334,-0.12037183,0.09795354,-0.05061132,-0.042333007,0.049688928,-0.060839288,-0.08577614,0.030943524,-0.07448185,0.070544206,-0.10139046,0.038617935,0.016046526,0.036523677,0.01709771,0.013089711,0.03702958,0.0050224955,0.025156995,0.00933741,0.002480933,-0.008008882,0.03458934,0.024178604,-0.039913677,0.036548644,-0.007822828,0.03241219,0.05773877,-3.6191615e-08,0.12418259,0.08759257,0.075568736,0.009616718,0.12341254,0.0010377936,0.025126923,0.008124289,0.014617785,0.01456785,-0.08455687,-0.06684226,0.0934286,0.012515176,0.019723289,0.031680077,-0.022893898,0.042716816,-0.019385597,0.035704616,-0.056193925,-0.032622475,-0.032868978,0.003490303,-0.0402501,-0.009706876,0.037860185,-0.022910912,0.004007148,-0.019224277,0.010135795,0.007978867,0.029933523,-0.08641561,-0.0028623897,0.08426226,-0.09061414,-0.071690716,-0.045472793,0.0014021547,-0.033197027,-0.012898758,0.045435082,0.016146002,0.009818225,0.008563516,-0.028177887,0.028863404,-0.016389327,-0.026844783,-0.00084874325,-0.014441852,0.048117634,0.022656502,-0.0737666,-0.05260895,0.04202238,-0.023890438,0.04774684,-0.012396939,-0.016164893,-0.047716137,0.09521816,0.09609559 +3.4.23.31,"Isolated from the imperfect fungus Scytalidium lignicolum. Not inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenyl)propane. A related enzyme from the same organism, proteinase C, is also insensitive to these inhibitors and has Mr = 406,000 [3]",384,0.99999994,0.010416943,-0.059954107,-0.14955889,-0.0018962303,0.12139916,0.10961272,-0.06468249,0.05444097,-0.0026589541,0.0035343864,0.06939202,-0.019659657,-0.020723417,0.020794764,-0.10827165,0.005092696,0.023688965,-0.020246273,0.04436935,-0.004411721,0.018168246,0.05216962,0.016506145,0.05432064,-0.007043953,0.00044584982,-0.026287377,0.0061282627,0.025545752,-0.06577134,-0.03934507,4.6566065e-06,0.038271934,-0.04394898,0.06503604,-0.0007000091,-0.11916857,0.038949575,0.05058343,0.0027728688,0.010475594,-0.06570306,-0.026626471,-0.0441896,-0.06264982,0.0014561869,-0.024255356,0.059669312,0.028270433,-0.04461997,-0.07032583,-0.09906246,-0.007346896,0.025538122,0.040926896,0.054165915,-0.02106637,0.034375224,0.06474149,0.034151457,0.051155347,0.02941851,0.004972626,-0.017944414,0.002278487,0.036717784,-0.012772145,-0.045741834,0.07948802,-0.017070519,0.03712368,-0.07775469,-0.028530778,0.019924,0.0075077103,0.049121987,-0.008941132,-0.051093068,-0.014701458,-0.032795735,0.007295116,0.016141323,0.005088872,-0.00085846684,0.0084358305,-0.012953963,0.002166954,0.058467507,0.08080881,-0.030317679,0.062234018,0.04902341,0.026721492,0.004733492,-0.06522634,0.06379567,0.04218086,0.036413852,-0.0039635436,0.017989082,0.09274843,-0.0005995841,-0.040273815,-0.09413595,-0.049920868,0.031004913,-0.003289426,0.026635826,0.061389048,-0.0044960347,0.043828752,0.01847004,0.010334925,-0.043130636,0.011701479,-0.012613318,0.10081254,-0.06584295,-0.011314296,-0.020336144,0.057018235,0.021156738,0.04375173,-0.01430877,-0.004794663,0.05481309,-0.046849538,3.0785297e-33,0.01690741,0.028256563,-0.02245996,0.03304282,0.05562158,-0.003738091,-0.016371839,0.006208822,-0.023628175,-0.04628218,-0.11902538,-0.033536524,-0.07526411,0.015201682,-0.05808405,0.02639001,0.02906421,-0.058835447,0.043472085,0.02700915,0.012448838,0.032196052,-0.13074674,-0.020527512,0.04127897,0.010980513,0.024563096,-0.02967736,0.12677422,-0.011857309,0.045213405,-0.052518174,-0.12352065,0.013751048,0.032447543,-0.030619247,-0.0053037684,-0.025216874,-0.053249028,0.033881135,-0.013335451,0.07634738,0.01960675,-0.060085755,0.068804204,-0.052596368,-0.072168,0.095480844,0.03508441,-0.029424883,0.06785231,0.022268193,0.06021969,0.04135556,-0.10025397,-0.0011275883,-0.0031239714,0.034334134,0.062198166,0.014045241,0.054844677,0.06250365,-0.034328073,0.03288518,0.029052608,-0.017933065,-0.09117543,-0.032053914,0.01644445,-0.058153927,-0.06720161,-0.0125790825,-0.0021915098,-0.024242464,0.016767584,-0.11969678,-0.063923664,-0.009862013,-0.026856305,0.056215443,-0.032952644,-0.004484176,0.031969886,0.0001940843,-0.10556682,-0.024987431,-0.07565097,-0.0025533459,-0.05590058,-0.019394973,0.032942303,-0.053966094,-0.055881824,0.1396832,-0.02102852,-3.2143526e-33,0.09052926,-0.077900946,0.14615071,0.0005383186,-0.045404084,0.12326496,-0.0071780263,-0.020841584,-0.004407004,-0.05777334,0.12609388,-0.04436816,0.0869117,-0.039729487,0.059525307,0.036685675,-0.023215326,0.06597275,-0.014889049,0.049267296,-0.03135913,0.04534316,-0.007158255,0.045185532,0.009820902,0.026022542,0.01929921,0.027429948,-0.010045357,0.035710044,0.034535546,0.020479435,-0.06970825,-0.090995386,-0.094842285,-0.030645568,-0.028141696,-0.04881693,-0.012862074,0.041200504,0.020634195,0.026241625,0.009264523,0.09953233,0.024758326,0.056385957,-0.04772574,-0.033003177,0.0041254163,0.02434581,0.018552063,0.0026986555,-0.07997048,-0.020761153,0.08623842,-0.0353749,0.00024034221,0.043049794,0.019464135,0.0022336873,-0.024468206,0.05110971,-0.07188497,0.056547206,0.09837232,0.14065036,-0.07243262,0.09844297,0.07252481,-0.093915686,0.061548293,0.0077848337,0.021522926,0.06262699,-0.016820434,0.031796694,0.045612484,0.0033586374,0.005410074,-0.050697263,0.08372072,-0.076348074,0.0825667,-0.0517617,-0.037478868,-0.06938643,0.040000293,0.020083133,-0.01427177,0.053700007,-0.023409154,0.01949308,-0.039425597,0.016199699,0.089244515,-4.530103e-08,0.041935753,-0.04550267,0.02176563,-0.098620735,-0.083830036,-0.09790564,0.055263236,-0.0026990315,0.0045270626,-0.019573953,-0.08989453,-0.05078454,-0.017372483,0.02979043,0.028760497,0.0048983074,-0.043763973,0.08719301,-0.034366705,0.033784162,-0.04722059,-0.027916258,-0.05252067,-0.008024073,-0.028658442,-0.054103266,0.009903915,0.013519818,0.04090079,-0.014064605,-0.052338608,0.01979221,-0.016715297,-0.00566104,-0.029645493,0.0611049,-0.035213888,-0.046204362,-0.054103054,-0.012049138,0.026513198,-0.0901979,-0.023725333,-0.09270917,-0.03752155,-0.07282859,0.0075668828,0.032911494,0.02801706,-0.0017804002,0.038408585,0.0040473975,0.0166676,-0.054867238,-0.049351357,-0.034440745,0.05639266,-0.01374525,-0.051453333,-0.1156822,0.018603334,-0.041247644,0.09469585,0.015867122 +3.4.23.32,"A second endopeptidase from Scytalidium lignicolum (see scytalidopepsin A) that is insensitive to pepstatin and methyl 2-diazoacetamidohexanoate. 1,2-Epoxy-3-(p-nitrophenoxy)propane reacts with Glu53, which replaces one of the aspartic residues at the active centre. One of the smallest aspartic endopeptidases active as the monomer, with Mr 22,000. Similarly inhibitor-resistant endopeptidases are found in the basidiomycetes Lentinus edodes [1] and Ganoderma lucidum [3], and in Polyporus tulipiferae [4], a second endopeptidase distinct from polyporopepsin, but these are of typical aspartic endopeptidase size, Mr about 36,000. Type example of peptidase family G1.",384,1.0,0.022270344,-0.08213391,-0.09140499,0.0057080677,0.12853682,0.08910301,-0.023329284,0.06261447,0.04543356,0.03756818,0.022502337,-0.027613116,-0.09515794,0.028402569,-0.055562746,0.031120343,-0.0059178285,-0.037897393,0.039145947,0.006314492,0.06228818,-0.00432099,-0.0075795176,0.036512464,-0.00306829,-0.003507807,-0.06853575,-0.10901664,-0.032220613,-0.06360973,0.0100651095,-0.09595257,-0.018381879,0.026104087,0.072518356,0.015407327,-0.07763141,0.016036695,0.03933774,-0.06640972,0.0707815,0.0033330705,-0.037704617,-0.028630262,-0.016026817,0.036989186,-0.019931637,0.06892191,0.047729712,-0.032573488,0.0056391885,-0.117628925,-0.020771496,0.008511514,0.012794932,0.04470315,0.009400225,-0.04970702,0.014398385,0.048545696,0.010035058,-0.008977019,-0.019859256,-0.084447466,-0.034895122,-0.01991924,0.026923474,-0.055781186,0.03885707,-0.0034376027,0.020365573,0.0347,-0.064588785,0.10246913,0.017897742,0.10437183,-0.054014776,0.018094888,-0.085029095,-0.065947734,-9.785599e-05,0.032106295,0.07287139,0.06783325,0.03804824,-0.025400106,0.024184732,0.115322866,0.0689645,-0.029938998,0.024261475,-0.0058582504,0.055432815,0.033653792,0.049190715,-0.013131498,0.023674743,-0.039015014,-0.014441151,-0.0459507,0.027836658,-0.040859286,0.01830148,-0.100748375,-0.007785769,0.058927074,-0.059896715,0.010724984,0.13106254,-0.033198882,0.021136565,-0.016007936,0.029704716,-0.042253453,0.040157206,-0.012434287,-0.0003735555,-0.025835773,-0.009167877,0.025458828,0.046172235,0.036063988,0.049598537,0.014811366,-0.022572644,0.10411028,-0.07486171,5.2970406e-33,0.011075723,0.040433913,0.045996565,0.016005334,0.03823401,0.039926063,0.008655067,0.026796406,0.001822989,-0.045244552,-0.15146264,-0.04853166,-0.027600065,0.035699066,-0.03411342,0.02455434,-0.012347062,0.015446814,0.01215008,-0.008173916,-0.05203484,0.0581903,-0.095555365,-0.04855258,0.027800456,0.039585896,-0.040285323,-0.042213745,0.083951145,-0.012387639,0.016266517,-0.07637008,-0.100350074,0.034858976,0.04974515,-0.020127922,0.060420725,-0.11183634,-0.05088151,-0.014418542,-0.015993746,0.041953854,-0.023132948,-0.014749838,0.065068655,-0.12089722,-0.0001936187,0.038364585,-0.004084494,-0.00055113004,0.0127874855,0.0051288763,0.09178717,0.026569895,-0.05074432,-0.013662898,0.021168571,0.065980546,0.07189432,0.012917803,0.076431096,0.021859605,-0.04893518,-0.062214788,-0.0022115908,0.021851398,-0.03782061,0.016951976,-0.02531549,0.03975138,-0.03918747,-0.013965803,-0.0050958283,0.03128772,0.033955164,-0.09914576,-0.042737015,0.0692615,0.0109211765,0.035979223,-0.0005658849,0.06171238,-0.008940767,0.005761547,-0.0802538,0.008469017,0.07137446,-0.021600595,-0.07683886,0.02975648,0.011936927,-0.0353218,0.004311826,0.09164715,-0.08206798,-4.249919e-33,0.0042689363,-0.093307935,-0.007089263,-0.028111238,-0.05136191,0.04119829,-0.009913975,0.043952014,-0.0014719063,-0.09636378,0.1262413,-0.038817983,0.08182784,-0.025796745,-0.009996678,-0.036339425,-0.033449236,0.08433238,0.0434818,-0.03715366,-0.036809254,0.031959552,0.038388163,0.051340114,0.08588131,0.026820052,-0.012855165,-0.003954131,-0.059210416,0.018303348,0.03999023,0.09373298,-0.02725372,-0.048319634,-0.07110363,-0.0116571905,-0.10634859,-0.052465636,0.067747846,0.04420735,-0.01842209,0.016923571,0.11315339,0.08100501,0.051885772,0.027365351,-0.07639246,0.017863963,0.02300338,-0.025211489,-0.02156716,-0.05540678,-0.06983964,0.04310112,0.039678566,-0.07629044,0.034559228,0.052844748,0.020381916,-0.041753944,-0.04308723,0.0026482001,0.024587171,0.06689441,0.10134566,0.07652862,-0.07065678,0.053661425,0.06899953,-0.049664717,-0.004198719,-0.06525846,0.028467825,0.06117386,-0.007969406,-0.009440275,-0.0046501188,-0.015463101,0.024641909,-0.05796298,-0.03147399,-0.04754566,0.04631026,-0.045850486,-0.014685622,-0.06829805,0.014889377,0.033711556,-0.02989732,0.07510471,-0.062845424,-0.011074832,0.03547593,0.06201165,0.06582058,-4.353698e-08,0.092196636,0.023691319,0.04828593,-0.100142755,-0.06463027,-0.05445551,0.0044275178,-0.0044810898,-0.0048443093,-0.07761897,0.0073274015,-0.0363307,0.025451826,0.039444055,0.02451824,0.008697017,0.0098311845,0.035214763,0.016639067,0.03793859,-0.087996475,0.013738807,-0.072070666,-0.06285933,0.012759718,-0.07823513,0.0472145,0.04380614,0.031148389,-0.0014759906,-0.001296292,0.008958098,-0.022056486,-0.0144959865,0.013435154,0.10235281,-0.050404258,0.0039029343,0.023283793,0.01949491,0.022823822,-0.058523335,-0.052579455,-0.07148234,0.013902692,-0.059273917,0.10723801,0.0015811214,-0.028674994,0.0034513767,0.04319002,-0.07714616,0.025020478,-0.038747903,-0.11111592,-0.051250666,-0.016978275,-0.014853609,0.0058811284,-0.09792801,-0.029758375,0.003428869,0.12460785,0.10998378 +3.4.23.34,"Found in stomach, spleen, erythrocyte membrane; not lysosomal. Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomer. In peptidase family A1 (pepsin A family)",384,1.0,0.005545283,-0.038477827,-0.09211498,-0.058096185,0.08020428,0.0101492135,0.026455274,0.12691018,0.06690805,0.016771287,0.056957066,-0.017463392,-0.036508977,0.06471489,-0.037866052,0.013332988,-0.043700576,-0.09407125,-0.040098377,-0.059290662,0.055757824,-0.033895195,0.045887843,0.070111044,-0.025201086,-0.06452531,0.04172826,0.0012984285,-0.013406198,-0.03015615,0.00081251404,-0.027028168,0.03985187,-0.049158756,0.05085652,0.0018989037,-0.005330228,0.033094205,0.06392789,-0.028162137,0.064051524,-0.059846472,-0.07062893,-0.05472944,-0.033760767,0.04348926,-0.001016594,0.1054956,0.024095282,0.0041526384,0.024409942,-0.06958536,-0.04457869,0.022556532,-0.03847585,-0.021221578,-0.064210415,-0.04653357,-0.018570868,-0.0020541914,-0.01175164,0.004264415,0.020228934,0.05012527,-0.011955801,-0.04050892,0.09063353,-0.011165918,0.0068578706,0.023601377,0.050098386,-0.059414074,0.013155675,0.12137802,0.064854585,0.06233471,0.09366924,-0.074671715,-0.07150345,-0.010480309,0.01101508,0.043381166,0.049558666,0.111330256,-0.008266038,-0.022594124,0.021395577,0.03322555,-0.0112306485,-0.06809777,-0.032013606,-0.09458687,0.07675179,-0.008861049,-0.08607312,-0.016958056,-0.059590805,-0.06537829,0.025559017,-0.0050689257,-0.05083864,0.023306562,0.08112237,-0.043135084,-0.03987987,0.037272982,-0.02643677,0.09967404,0.08387279,-0.05010993,0.083173364,-0.04971636,0.057915535,0.012356673,0.010640921,0.016193978,-0.0020288369,-0.021124696,0.045397326,0.029000191,-0.016292674,0.052426748,0.025335588,0.05044703,-0.05172661,0.07861269,-0.10267635,2.1624864e-33,-0.01958967,-0.040220283,0.07130517,-0.052912395,-0.0014939245,0.054267224,-0.0026031195,-0.017444307,0.00782432,-0.07293997,-0.10778964,-0.09806583,0.057055403,0.03596681,-0.06533208,-0.019198786,-0.04635974,-0.008185933,0.024219723,0.048991065,-0.081032686,0.031547926,0.0032034807,-0.061514206,0.06312208,0.040571973,-0.031303734,0.010348205,0.091542,-0.009199947,-0.0020008855,-0.044510048,-0.046589103,0.10867419,-0.031022804,0.026315501,-0.0071928143,-0.059856977,0.09581103,0.026180428,0.0011871103,0.012789087,0.015218715,-0.012427234,0.082304806,-0.05201334,-0.08323873,0.022044506,-0.022055775,0.005296405,0.11484989,-0.032717757,0.05173296,-0.0855116,-0.07543102,0.005578522,-0.040437818,0.06941158,0.102400266,0.086830616,0.05630818,0.11387732,-0.044581953,0.0314997,0.0101991575,0.027900754,-0.07868483,-0.054719906,-0.059254944,0.017795775,-0.020589856,0.046349738,0.15366925,-0.0034735,0.048869956,-0.026876923,-0.013830959,-0.021146618,-0.016019907,0.094758205,-0.02633402,0.013813374,-0.06256251,0.022125889,-0.051376108,0.028422367,-0.0021405283,-0.033735875,-0.03051943,0.047308896,-0.04079632,0.014609411,-0.07251705,0.017446086,-0.059338015,-3.191031e-33,0.005788475,-0.07354499,0.040973336,-0.041503567,-0.013709476,0.05253571,0.065711305,0.0004647021,0.037475143,-0.010071386,0.09470503,-0.0022057365,-0.038477577,-0.04191588,0.044442207,0.07239021,-0.08982385,0.041717175,0.032060534,0.018434193,-0.031128714,0.04881845,-0.03171471,0.06282499,0.061061155,-0.026337706,-0.0062050386,0.027013825,0.05799843,-0.041066714,-0.03302215,-0.027135007,-0.09285076,-0.04330418,-0.03758486,0.0018644116,-0.050696816,-0.07208241,0.04606904,-0.07214668,-0.098251574,0.03286932,0.028263928,0.07712611,0.041731194,0.067467526,-0.032442868,-0.009576035,0.03305318,-0.016907543,-0.059931785,-0.026479132,-0.02536852,0.023932239,0.005471239,0.03183563,0.016688,0.053418484,-0.017068319,-0.045292884,-0.015745433,-0.026422892,0.0067841457,0.09307261,0.022990048,0.016073084,-0.06913836,-0.03819734,0.005153857,-0.009800174,0.09794899,-0.015896361,-0.046496715,-0.08088888,-0.036882654,0.023944385,-0.082057804,-0.01740858,-0.010952992,0.0049465266,-0.007493479,-0.051206674,0.023640074,0.00749365,0.012992589,-0.042294767,-0.018034302,0.08128676,0.035042685,0.0642009,0.048560187,-0.011404634,0.016849395,0.013105162,0.102542534,-3.518865e-08,0.15456204,-0.05030865,-0.005715201,-0.06373628,-0.032502316,-0.08599992,0.00178279,-0.039841454,0.020540275,-0.001317796,-0.038067438,0.018578729,-0.062007125,-0.027475264,0.034653295,0.026542936,0.03216147,0.06345604,-0.00824996,0.004995715,-0.057130978,-0.0018460453,-0.07838061,-0.004539508,-0.031336486,-0.03397754,-0.0068465313,-0.057636876,-0.06833614,-0.077776976,0.0016498333,0.015679108,-0.03333485,-0.05759155,0.076518595,0.01717852,-0.021835443,-0.0036411998,-0.00804645,0.023059215,0.00862835,-0.08366372,0.028540228,-0.04105513,0.01409715,0.014777068,0.06009608,-0.0013752168,-0.005104016,0.0015605284,-6.836819e-05,-0.0125039015,-0.028367769,-0.029612094,-0.07716795,0.023309601,-0.057218157,-0.076249875,0.009228524,-0.06170391,0.06156468,0.07680897,0.17593141,0.011271084 +3.4.23.35,A secreted endopeptidase known from baker's yeast (Saccharomyces cerevisiae). In peptidase family A1 (pepsin A family),384,1.0,-0.02566539,-0.008336736,-0.09513729,0.006527553,0.0496098,0.06674195,0.043851472,0.06543298,0.0625921,0.03062518,0.09816391,-0.059065357,-0.1214819,0.03490157,-0.07901228,-0.00646495,-0.050570514,-0.07063006,-0.026981672,-0.06464665,0.08281722,0.03223823,0.06743434,0.04975725,-0.05483779,0.015315205,0.018212022,-0.07926576,0.00042057745,-0.07988423,0.059155002,-0.09792128,0.07819077,-0.015635613,0.056335893,0.04028272,0.029728489,0.0027580145,0.07298004,-0.029070957,0.042481914,-0.014343053,-0.058544368,0.028087003,0.0013765473,0.07645232,0.010480873,0.10023296,0.008633297,0.0354607,-0.006202923,-0.110667124,-0.0066344566,-0.08116644,0.04429594,0.07218847,-0.009891126,-0.035884503,0.017737,0.06684735,0.046390574,-0.052410975,-0.009122758,-0.013581919,0.0048218616,-0.077221155,0.038943704,-0.025329033,0.04789056,-0.030396428,-0.017943444,-0.046450026,-0.071694545,0.024955183,0.005032803,0.094055995,0.0040395265,-0.08069632,-0.0732884,-0.02092048,0.028586155,-0.012035907,0.09831374,0.065676875,0.013525357,-0.017014194,0.018275702,0.06310569,0.011281189,-0.0015122927,-0.038703173,-0.11378854,0.028731743,-0.02216709,0.0088812,-0.020071652,-0.0073923026,-0.086222015,-0.023344854,-0.026609844,0.0041563124,0.0076726605,0.022728678,-0.07797126,-0.0016266446,0.06522559,-0.074116,0.028028894,0.12668823,-0.011947662,0.0042314157,0.004396534,0.0239973,-0.062613636,0.016222136,0.00080217107,0.019167615,0.007896919,0.014716775,0.04203504,0.0067622876,0.06637488,-0.0033771459,0.040047605,-0.06907747,0.05598691,-0.084163204,4.1103506e-34,-0.027392102,0.01936604,0.006198724,0.01224784,0.018443448,0.071526736,-0.015570433,0.028135989,-0.02111518,0.0015966492,-0.041804332,-0.09515484,-0.027562805,0.061534956,-0.031767577,0.022605088,-0.055489257,0.015605545,0.051016547,-0.02739902,-0.04070564,0.09760261,-0.020302102,-0.08811589,0.053149592,0.055425912,-0.04021019,0.012215924,0.0941759,-0.019217964,0.043473937,0.00236444,-0.033800602,-0.009317003,0.038119804,0.0049909335,0.08719216,-0.1143304,0.0102874255,0.022422027,-0.0069421236,-0.0074746204,-0.013201252,-0.00847209,0.021450667,-0.0932964,-0.019894939,0.036947247,0.06545452,0.023950558,-0.018257795,-0.036379673,0.07525793,-0.059929766,-0.03023511,0.017599313,0.0004986724,0.06618174,0.04239349,0.028438363,0.012056917,0.097683005,-0.08781838,-0.02201535,-0.065985784,-0.007673118,-0.035440724,-0.008859474,0.0025928055,0.06031982,-0.04797943,-0.0015520052,0.029429503,-0.018006554,0.0030359514,-0.03829892,-0.11967407,0.035540666,0.015650136,-0.028931253,0.05143845,0.018602842,0.031345833,0.020503042,-0.06647378,0.014581445,-0.027707605,-0.026525587,-0.10149616,0.05895836,-0.06296249,-0.031778716,0.008489849,0.07002125,-0.06277215,-2.2130037e-33,0.010742165,-0.03410798,-0.037203718,-0.030194303,-0.011281354,0.04210094,0.00750992,0.0021725977,-0.046167366,-0.031499535,0.05646603,-0.06250831,0.097882025,-0.051122304,-0.0021571368,0.030112194,0.01677399,0.06675439,0.019930016,-0.06255303,-0.047465075,0.018019166,-0.016514378,0.024820197,0.12837395,0.02615144,0.016860945,0.075299054,-0.0015890065,0.008375741,-0.031286035,-0.014402691,0.04953252,-0.05359216,-0.043947514,0.03997612,-0.12742843,-0.018996112,0.007906652,0.0057370863,-0.016908936,0.012663749,0.051280335,0.11269763,0.008315941,0.043051627,-0.07334853,0.01686466,0.030619211,-0.02848576,-0.037788723,-0.061936807,-0.043743435,0.01936257,0.008777778,-0.02981027,-0.0263731,0.028185677,-0.00066155323,-0.06612921,0.011601804,-0.016135592,0.061556138,0.05934922,0.111331664,-0.007493337,-0.105377026,-0.0003115116,0.036716923,-0.0069561345,0.09053578,-0.0045310687,0.03082831,0.03103085,-0.04357186,0.03669227,-0.08205564,-0.056017194,0.025599439,-0.011994716,-0.06851474,-0.036227617,0.05021018,-0.002040244,0.07379865,-0.076730706,0.021655772,0.054465145,-0.043306608,0.100394964,-0.033141218,0.009171019,0.0034469964,0.038255304,0.054425433,-2.6877553e-08,0.12866046,-0.039997786,0.07151377,-0.11884525,-0.00072301045,-0.03879348,0.06879502,-0.000120088946,-0.04425767,-0.0154307075,-0.035820216,0.036499605,0.038605817,0.10292921,0.012493276,0.03884149,0.0029688587,0.037827455,0.028556807,-0.025518032,-0.11347859,0.010392693,-0.045199208,-0.06949376,-0.04159918,-0.063094236,0.03862474,0.058181148,0.025738807,-0.0010007938,-0.010272703,-0.0191968,-0.025164628,-0.042588625,-0.009954679,0.1544837,-0.07131396,-0.01239053,-0.05673371,-0.0015109789,0.0047409055,-0.03002249,-0.028849494,0.009524633,-0.016153075,-0.071422845,0.11706614,0.030394316,-0.060166907,-0.01868311,0.045396667,-0.018646777,-0.051682964,0.0068134964,-0.089544915,-0.030824408,-0.05841832,-0.06162983,-0.00837696,-0.07217492,0.0146742,0.034709774,0.15345669,-0.0041116658 +3.4.23.36,An 18-kDa enzyme present in bacterial inner membranes. Inhibited by pepstatin and the antibiotic globomycin. Type example of peptidase family A8.,384,0.99999994,-0.08391249,-0.054301407,-0.09131423,-0.06610151,-0.06495487,0.056263752,-0.019892877,0.08651455,0.07169593,0.013247477,0.032890037,-0.009095079,0.015778711,0.11693478,-0.041439798,0.010053076,-0.053282164,-0.07209346,-0.01922423,-0.071982734,0.028039554,0.047092814,-0.021928491,-0.007981758,-0.026636777,-0.005059913,0.055275865,-0.041052166,-0.0058219363,-0.031509146,0.011821208,-0.030395579,0.08937601,-0.048342332,0.13375263,-0.008152369,-0.044340022,0.018567199,0.09899813,0.014850642,0.0009260936,0.01630281,-0.03614949,-0.051789347,0.04766546,-0.028488288,0.0041293963,0.061061345,0.10855607,-0.03988176,-0.050233956,-0.027558956,-0.05085547,0.053458083,0.078209616,-0.03158102,-0.059827507,-0.050389506,0.064727776,0.027734153,0.037184644,0.03655337,0.063798375,0.02157096,-0.09574926,-0.08400955,0.04759582,-0.029133653,0.040492013,0.007869703,0.003904655,-0.06961403,-0.01710584,0.0021358165,0.0027127212,-0.033385087,0.009268603,-0.076816045,-0.0795706,-0.0445892,0.025154699,-0.047413036,0.061721493,0.0738546,0.0074224374,-0.057701655,0.08413216,-0.025219435,0.06577548,0.0061846026,0.052817885,-0.06026895,0.032515176,-0.021582618,-0.058538154,-0.079861104,-0.06754423,-0.026396984,-0.0031352832,-0.0017789637,0.022610545,-0.03149475,-0.007816593,0.023004832,-0.002549747,0.075900376,0.04621631,0.05763519,0.044668842,-0.012527167,-0.024819696,0.024698887,-0.020769788,-0.04318647,-0.04068846,-0.0074634734,0.10667874,-0.013694143,-0.024856279,0.07067228,0.030753274,-0.012935359,0.03186695,0.050649848,-0.059938636,0.06181544,-0.097714774,1.3971284e-33,0.004976938,-0.028697008,0.020749731,-0.06680389,-0.0155056,-0.054926477,-0.0625803,-0.05415301,-0.0056237835,-0.061169714,-0.08115109,-0.055899728,-0.017459892,0.024127508,-0.023126507,0.09680374,-0.04959598,-0.007283947,0.010781964,0.024067631,0.023795819,0.057367824,0.024085818,-0.03291136,0.12925868,-0.028486112,0.02954697,0.006238083,0.10451773,-0.017805371,-0.038216997,-0.0789312,-0.12164373,0.009569031,-0.021608662,-0.032565393,0.009166091,-0.02923403,0.035775952,0.00087718986,-0.052671142,0.017745001,-0.005678086,-0.016814077,0.08340984,-0.004360899,-0.07513848,0.08924479,0.0068290783,0.022399746,0.025153324,-0.037185233,0.014331973,-0.0015415078,-0.047957614,0.032267265,0.019763699,0.044477124,0.09364329,0.046503168,0.10592827,0.019351747,-0.034332547,0.0119521255,0.0020613612,0.008407702,-0.022717353,-0.038284644,0.016012972,0.04744819,-0.14025906,0.032796144,0.04821381,0.042474452,0.05565517,-0.13976221,-0.047259096,-0.018233867,-0.0008512312,0.039956268,0.049584612,-0.011113367,0.05025538,0.001190662,-0.04149823,-0.026304578,-0.03119897,-0.0033446222,-0.055399466,-0.017156528,0.014883893,-0.06244939,-0.07064675,0.106872216,-0.040958613,-3.7526162e-33,0.09728503,-0.058847606,0.11364595,-0.102225006,-0.021453572,0.08416863,0.021542996,0.01983549,0.0082462905,-0.04493561,0.024131833,0.011071721,0.035481278,-0.018265711,0.012719358,-0.009628647,-0.02268263,0.047592346,-0.06424957,-0.037300795,-0.074773036,-0.010469583,0.014849714,0.04036475,-0.028371893,-0.014443618,-0.050052896,0.07894882,0.012365185,0.00863301,-0.043223817,-0.005407557,-0.06420784,-0.029601993,-0.046326753,0.037341345,-0.0029559652,-0.040657576,-0.0060661477,-0.073381364,0.034521516,0.07743504,0.045749184,0.059817187,-0.07007937,0.107833944,-0.043820426,0.015659442,-0.051852886,-0.072876394,-0.014184949,-0.0029229121,0.02728832,0.01950716,0.002883824,-0.010281804,0.031844683,0.07203684,0.024006067,0.037198316,0.028561424,-0.08866988,0.046639405,-0.020422801,0.018359102,0.05450965,-0.04274097,0.014694122,0.1098144,-0.020371672,0.054316975,0.02089846,-0.044085193,0.0166581,-0.011110466,0.04629573,-0.053484462,-0.13619526,0.042890314,0.00040067715,0.033874158,0.0025209812,-0.00987235,0.04232258,0.028388787,-0.03414753,0.0715097,0.03781633,0.047503266,0.05823663,0.06277083,-0.023923807,-0.020495586,0.043172825,0.02163451,-2.8776736e-08,0.09022299,-0.076154254,0.042326387,-0.07746136,-0.04581566,-0.03666825,-0.04914188,-0.011425821,0.023105443,-0.05711354,-0.005009254,0.056515057,-0.033022627,0.035561755,-0.050568637,0.07098386,-0.06630114,0.017385114,0.041752804,0.009237202,-0.048256908,0.015413262,-0.08872569,0.054047346,0.014851318,-0.04702268,-0.02733592,0.024999432,-0.07267061,-0.024006518,0.013300064,0.035610955,-0.0502163,-0.020181747,0.00246145,0.032464985,-0.039986793,-0.014020109,-0.026656084,0.009170744,0.11754944,-0.05842306,-0.05693734,-0.054537285,0.01641559,0.02218207,-0.010242551,-0.013104158,-0.06551973,0.009620743,0.07738694,0.017586993,-0.018710278,-0.03579724,-0.12629144,0.011245483,-0.02443845,-0.13660298,0.025343433,-0.06105469,0.016792286,-0.013784565,0.15619373,0.048971944 +3.4.23.38,"Known from the malaria organism, Plasmodium. About 37 kDa. In peptidase family A1 (pepsin A family), closest to cathepsin D and renin in structure. Inhibited by pepstatin. Formerly included in EC 3.4.23.6",384,1.0,-0.021509966,-0.005868574,-0.08025075,-0.08716531,0.025110602,0.065840445,-0.019883994,0.10225254,0.035313297,0.034097478,0.020935712,-0.042131614,-0.030369079,0.05376066,-0.08758218,0.01277837,-0.06319668,-0.042462792,-0.012236196,-0.07695932,0.047041338,0.049744174,0.101095706,0.047704,-0.065432966,0.025525527,0.057918027,0.010974399,0.026625048,-0.043263566,-0.048607364,-0.042052027,0.06137707,-0.025412438,-0.001458938,0.029356893,0.013790853,-0.041658953,0.06651069,0.0024027568,0.06951042,0.0285192,-0.03987892,-0.0830884,0.00012285779,-0.04652163,-0.039751753,0.11886164,0.036287602,-0.0021314337,-0.012153732,-0.089642294,-0.050818507,0.050200175,0.08889216,-0.001213114,-0.045717426,-0.05296483,0.039524265,-0.004292503,0.029588819,0.012613115,0.01134492,-0.003588733,-0.049215816,-0.0018417337,0.014973734,-0.06098179,0.013408175,0.0040229214,0.052324206,-0.055224564,-0.0026891537,0.064805724,-0.05926315,0.024901489,0.07082098,-0.05501917,-0.106057115,-0.047439,0.02031396,0.0403753,0.08628762,0.095419854,-0.0041814353,-0.03793582,-0.026299348,0.014579766,0.030361816,-0.07066568,0.008176473,-0.07958499,0.09888869,-0.011308157,-0.08448505,0.02429521,0.0010418065,-0.056822896,0.036736503,0.032501884,0.013741665,0.018684829,-0.032063086,-0.039292324,-0.0693211,0.07802128,-0.047807112,0.06266792,0.059492636,-0.0091072135,-0.045290776,0.0038246177,-0.014397506,0.017394416,-0.037273567,-0.073041156,0.021264113,-0.05232759,-0.010832017,0.032821268,-0.0008875543,0.029702371,0.010464951,0.034227554,0.034286235,0.05370226,-0.106566265,9.058922e-34,0.057942905,-0.06330157,0.11123715,-0.010189845,0.022047507,0.055653565,-0.0019829068,0.060802046,0.0050879447,-0.08755527,-0.13436301,-0.059878226,-0.00091867516,-0.0074816463,-0.07481858,-0.007119889,-0.0046438845,-0.020575576,0.014888383,0.05343209,-0.025807561,0.05688152,-0.019644463,-0.05407346,0.08326005,0.072020106,-0.030275235,-0.006799346,0.12434007,-0.005038627,-0.022419969,-0.033184044,-0.1278855,-0.011014901,-0.047304656,-0.005228925,-0.012697818,-0.06715076,-0.0055097453,0.09019613,0.012379857,0.018088376,-0.027600594,-0.07712729,0.03210949,-0.036817826,-0.040787082,-0.0042275614,-0.0012128816,0.02087222,0.015577512,0.00469736,0.0021880714,0.011165035,-0.08526861,-0.01229236,-0.019692978,0.007594655,0.08517154,0.07902352,0.09751961,0.011077558,-0.0020593992,0.034524564,0.03407146,0.022567196,-0.07564478,-0.03306792,0.029072149,0.00032211782,-0.024344979,0.047954727,0.0033772676,-0.012071026,0.06827377,-0.114378415,0.0060624764,0.010165181,-0.021107068,0.08054999,-0.026844067,-0.010402412,0.03690446,0.021177603,-0.11039606,-0.00581739,0.0010102475,-0.04104511,-0.06334325,-0.020003658,-0.081146486,0.0031885642,-0.07999482,0.026861755,-0.029945696,-2.12809e-33,0.07008343,-0.072760224,0.1018296,-0.07539583,-0.00300981,0.06528554,-0.02126399,0.07435567,-0.0366134,-0.07432043,0.07008201,-0.0062242136,0.062424675,-0.0324804,0.0127318865,0.12079264,-0.048076168,0.00794071,-0.023911376,0.009837042,-0.08188619,-0.041871343,0.016829986,0.05326853,0.006256887,0.0043936907,-0.0052815867,-0.009957639,0.038318414,-0.013412587,-0.028316714,0.0070956238,-0.08760387,-0.054201942,-0.04849255,-0.021388812,-0.0449305,-0.022216382,0.0089368215,-0.018610567,-0.011579286,0.12680832,0.016165156,0.104298845,0.055046692,0.10437132,-0.021469345,-0.00083682267,0.028888112,-0.04277542,0.010201528,-0.047659922,-0.004732526,0.03177237,0.09124529,-0.056920458,0.00077330443,0.025129277,0.06311706,0.024929376,0.026673982,-0.039974608,-0.045401108,0.08150301,0.06660822,0.014628465,-0.085070945,0.04973639,0.07639767,-0.037654344,0.07268338,-0.061329704,0.0054942183,0.024149057,-0.06826255,0.037210453,-0.024611361,-0.048968446,0.021856852,-0.012873875,0.0034490596,-0.036650978,-0.031337857,0.009428307,-0.0191923,-0.015511127,0.10960975,-0.00014479864,-0.049198706,0.07658677,-0.022358391,-0.011789347,0.03382528,0.051840436,0.06502673,-3.1888135e-08,0.13713083,-0.06954232,-0.005832232,-0.02874095,-0.0057461155,0.0026165545,-0.03748837,0.034355626,0.034295853,-0.0044243666,0.012789719,0.012012118,0.05901955,0.06752493,0.023891034,0.06669538,0.024544844,0.0098477,0.029002108,0.07181399,-0.09279062,0.039260786,-0.05621029,-0.01370213,-0.011049684,-0.08198838,0.013719937,-0.0014078134,-0.03596341,-0.0035516075,-0.08157703,0.031332213,-0.004510673,-0.07401123,0.07617824,0.06791235,0.0068427785,-0.052572582,0.0021311445,-0.027601186,0.03974219,-0.06955132,-0.019572275,-0.051965423,0.008960302,-0.04954228,0.03727871,0.016665502,-0.019159846,-0.0530456,0.02577428,0.05959445,0.0039084894,-0.082365625,-0.0848414,-0.004790802,-0.050533798,-0.099166684,-0.024139302,-0.094680615,0.07437038,-0.04722246,0.10176714,0.08350013 +3.4.23.39,"Known from the malaria organism, Plasmodium. About 37 kDa. In peptidase family A1 (pepsin A family), and is 73% identical in sequence to plasmepsin I. Inhibited by pepstatin. Formerly included in EC 3.4.23.6",384,1.0,-0.050784178,-0.009360746,-0.07878031,-0.07760762,0.040152967,0.069430515,0.01284098,0.117504716,0.03664036,0.03304549,0.018111521,-0.061717093,0.0048980676,0.031107727,-0.06759438,0.019131439,-0.04495759,-0.0706814,-0.012884879,-0.102210335,0.04358415,0.034755882,0.10580396,0.062096976,-0.06604001,0.03753077,0.060191847,0.024563948,0.036874518,-0.042054415,-0.033478502,-0.04121834,0.07864848,-0.04288866,-0.02080678,0.013420885,0.0059734825,-0.05839667,0.06584647,-0.0050827493,0.09581423,0.058555465,-0.058055483,-0.061811045,0.011354756,-0.047103256,-0.035229877,0.13810417,0.033574034,0.022166856,-0.0070710056,-0.07716808,-0.06437577,0.034929443,0.105425045,-0.006685266,-0.0608126,-0.03307951,0.041743923,0.012683284,-0.0026980313,0.006358159,0.0064004315,0.0043999837,-0.022570342,0.022681387,0.0173164,-0.08523938,-0.0028783614,0.004171144,0.035825174,-0.031890392,-0.0035309335,0.0714743,-0.072494216,0.03152778,0.05214347,-0.017214388,-0.11854287,-0.018245272,-0.00703848,0.006589511,0.07466338,0.0393438,-0.025314715,-0.056353565,-0.00021415357,0.025593435,0.042389393,-0.081504,0.011671613,-0.07631298,0.10378515,0.0016766489,-0.070742086,0.055886585,-0.008608535,-0.053682067,0.04479278,0.02966553,0.018093135,-0.023603247,-0.017963529,-0.026176563,-0.08293561,0.07243311,-0.04281483,0.056217305,0.037257552,0.012274873,-0.056931943,0.008369352,-0.009062976,0.039390497,-0.036761828,-0.07101418,0.022863647,-0.021549156,0.0021367029,0.040166985,0.009087712,0.0027024015,0.037943307,0.014643897,0.02951098,0.028528478,-0.0932322,7.3719186e-34,0.014022399,-0.063218094,0.12756833,0.011660887,0.022327894,0.04332337,-0.0032554606,0.063978374,0.031084914,-0.0774234,-0.12266708,-0.043584485,-0.011534057,0.017815558,-0.07295177,0.011650588,-0.019399853,-0.012778308,0.018681813,0.065344274,-0.0503575,0.033289988,-0.0059787836,-0.059701536,0.08862112,0.0815478,-0.017336441,0.01489817,0.10913659,-0.014235925,-0.012684545,-0.012662479,-0.11576294,-0.043585677,-0.02892538,0.0066748164,0.006590063,-0.07385258,0.0014227097,0.08895432,-0.0031174086,0.009659591,-0.014062439,-0.06556352,0.029365977,-0.037745465,-0.06585721,-0.031200454,0.02641198,0.006873711,-0.020174537,0.010916364,0.0104329325,0.015252803,-0.057647143,0.0038842412,-0.024877444,0.031904038,0.085318565,0.049881108,0.12169337,0.024283411,-0.003389057,0.023282189,0.020161275,0.051476445,-0.093537636,-0.014482293,0.036203086,0.010186104,0.016050577,0.053027555,-0.029862788,-0.010170024,0.061365917,-0.14180626,0.013716751,0.0047189766,-0.017407324,0.08655786,-0.02209249,-0.015964458,0.06719462,-0.019011326,-0.12539314,-0.020128677,0.0030408225,-0.018589912,-0.030679729,-0.015517098,-0.013612102,-0.010020671,-0.045080286,0.03950568,-0.04909847,-2.261457e-33,0.038195334,-0.05474862,0.10390341,-0.06120248,0.007941865,0.05311953,-0.029017657,0.08723634,-0.042780723,-0.03656577,0.054252017,0.006066538,0.04284068,-0.048294112,0.0225774,0.10509302,-0.039918996,0.034401078,-0.043609772,0.008286052,-0.08352482,-0.061284784,0.055103835,0.037963156,-0.01668138,-0.009561726,-0.0148087805,0.029168565,0.037188247,-0.03299323,-0.035521306,-0.005430663,-0.08206621,-0.05466461,-0.049798504,-0.07059297,0.0074089644,-0.0097424,0.011005611,-0.01929805,0.030051628,0.116223805,0.0030226815,0.08384937,0.033705436,0.08421265,-0.003409814,-0.014930989,0.030471876,-0.06286411,-0.00375219,-0.027065624,-0.021206612,0.030024767,0.09284837,-0.08514527,-0.019198598,0.027290864,0.065212026,0.0021814757,0.019629192,-0.052312057,-0.062704146,0.097465396,0.09617611,0.014162713,-0.07911372,0.044463567,0.0771568,4.722391e-05,0.06458028,-0.08959893,-0.041907206,0.018439675,-0.053282846,0.058203038,-0.032566093,-0.08076796,0.0051258374,-0.034037083,0.03198354,-0.065276876,-0.03669127,-0.019439155,-0.027015524,0.0039722193,0.11906075,-0.0042013065,-0.044237524,0.08757903,-0.010722629,-0.015646871,0.006726255,0.05274601,0.049446788,-3.3071117e-08,0.124956146,-0.06844756,-0.0048773647,-0.014985297,-0.027767021,0.0148860235,-0.057184827,0.008452261,0.050431944,-0.017545685,-0.011491851,-0.0062785246,0.030207941,0.077235684,0.008312863,0.0629921,-0.035885416,0.034967747,0.054731622,0.076111086,-0.07439447,0.03755936,-0.01868002,0.002626532,-0.0041668736,-0.05443253,-0.008139525,0.034793496,-0.026744373,0.0011963838,-0.10043814,0.00483511,-0.022759497,-0.06430349,0.04024521,0.03801179,0.031983398,-0.03329345,-0.009422514,-0.017364545,0.056630094,-0.07561071,-0.03231732,-0.06569552,0.02180099,-0.047478996,0.015804168,0.0039835153,-0.028959025,-0.07499124,0.01395268,0.041068073,-0.0011028472,-0.08682168,-0.07139247,-0.04399339,-0.063603744,-0.08408356,-0.020204553,-0.08354911,0.07637137,-0.04109905,0.09323107,0.077435136 +3.4.23.40,"Known particularly from barley grain, but present in other plants also. In peptidase family A1 (pepsin A family), but structurally distinct in containing an internal region of about 100 amino acids not generally present in the family",384,1.0,-0.050703943,-0.080364086,-0.09446974,-0.03736907,0.055041667,0.08440689,-0.00190169,0.058635883,0.06433851,0.009604371,0.13132766,-0.04243953,-0.02126466,-0.006511052,-0.042763475,-0.007051207,-0.046286557,-0.080178015,-0.058535155,-0.12106309,0.031172108,0.041715894,0.04303048,0.082218364,-0.033259023,0.0025972577,0.015791569,-0.028996436,0.049481172,-0.058166258,-0.007162366,-0.025706723,0.108181044,-0.032162525,0.08792186,0.02695686,0.0020714316,-0.053483177,0.102300815,-0.027329896,0.052142635,0.039528523,0.035569597,-0.05868763,0.020295946,0.01633554,0.04486997,0.08200289,0.06271457,-0.007225904,-0.0242629,-0.07031624,-0.014802074,-0.028754013,0.08476653,0.0650695,-0.0193698,-0.014689305,0.007916493,0.056882612,0.0064561814,0.025439888,-0.026508506,-0.019315077,-0.05693476,0.047161903,0.01154881,-0.027949102,0.03671132,-0.01520471,0.038127095,-0.055590086,-0.017825762,0.09307757,-0.065026015,0.05286176,0.019233778,-0.049642786,-0.0929142,-0.032748364,-0.048821878,0.013864537,0.078775436,0.027104232,-0.045880936,-0.03200611,0.018318597,0.016549543,0.025965562,-0.06772355,-0.014164527,-0.096728966,0.091275394,-0.013097528,-0.02061714,0.025144577,0.07583822,-0.11949491,0.008368606,0.012502568,0.047873832,0.008148115,0.031089928,-0.023242557,-0.06434991,0.08038051,-0.10822612,0.03287923,0.044804856,0.012407103,-0.04565714,-0.0025626777,-0.04148822,-0.028503237,-0.06936313,-0.05151513,0.05637021,-0.025187263,0.03035963,0.03895505,-0.018084312,0.01646903,0.054260205,0.03530966,0.0056661107,0.06255864,-0.13793987,-2.4507609e-34,0.0062547554,-0.034302343,0.03223576,0.011496624,-0.014068462,-0.00079298916,-0.008113073,-0.01845884,0.042082585,-0.1098443,-0.08533663,-0.040589254,-0.019414015,-0.004384716,-0.045470286,0.04535196,-0.05103381,-0.025403636,0.018739596,0.06298791,-0.14414467,0.096249424,-0.023450833,-0.05302993,0.014413173,0.018872306,0.08612105,-0.03244585,0.0059497505,-0.031506266,0.0092799105,0.029215755,-0.08839086,0.01774486,0.0218867,0.0125637585,0.01856692,-0.08017505,0.028446687,0.08921005,0.02523074,0.031248404,0.058858696,-0.042412724,0.07584858,-0.011819071,-0.03849268,0.0029276276,-0.0293385,0.034258857,0.025892606,0.02042423,0.058654197,0.011526166,-0.06666942,-0.0022259154,-0.0011751875,0.031511925,0.0906395,0.06673837,0.031145398,0.029373346,-0.041259807,0.013867203,-0.021243699,0.051517908,-0.16204754,-0.008614818,0.060156826,0.09978861,-0.024485769,-0.0051638964,0.040600523,0.025076421,0.05817979,-0.073729634,-0.05539935,0.011906697,-0.04110762,0.04895752,0.000791921,-0.01956206,0.08522131,0.02267387,-0.101529524,0.0015306378,-0.037267335,-0.023963107,-0.042461913,0.02811995,-0.014209254,-0.010875889,-0.026803007,-0.00025247884,-0.018771863,-1.7065994e-33,0.04264384,-0.018684428,0.03794393,-0.06407371,-0.04091246,0.006560496,0.012759411,-0.0027647167,0.0503459,-0.02570984,0.055538956,0.039385915,0.041636784,-0.07779443,0.036587313,0.08807752,-0.008292524,0.085860014,0.007843281,0.0014273806,-0.061635792,0.02371336,-0.021489477,-0.009371698,0.05951726,-0.024625564,-0.03150243,0.061951052,-0.0058691096,-0.065771855,-0.024466708,-0.017538788,-0.01675011,-0.037165403,-0.028526226,-0.052976504,-0.045234267,-0.058324594,-0.040909264,0.019295229,-0.038068023,0.07988123,0.06066813,0.078544036,-0.031130219,0.022573227,-0.03766286,-0.012487505,-0.036782887,0.016617551,0.027826278,-0.06640014,0.021261856,0.0132055245,0.04867038,-0.0592498,0.012425824,0.11040615,-0.050975315,0.023794545,0.022039995,0.0023672648,-0.0074810656,0.028227655,0.041997693,-0.046031423,-0.11814797,-0.02607561,0.06111758,0.012193497,0.062419053,-0.024875527,0.05595054,0.0297531,-0.024140833,0.0725923,-0.0725778,-0.07075751,-0.015248632,-0.046212703,-0.032334656,0.0027676332,0.0047408515,0.01867825,0.037983526,-0.04130269,0.02961479,0.07266797,0.057513077,0.045516416,0.05398633,-0.025529768,0.027075939,0.044115286,0.07791759,-2.9340498e-08,0.070062876,-0.056502335,-0.054559074,-0.052007668,-0.07003056,-0.03531831,0.029154496,-0.00813909,0.009349429,-0.046581108,0.0011022914,0.057373792,-0.027153445,0.053916592,-0.047607623,0.0490087,-0.04899773,0.04214311,-0.008041194,0.0985308,-0.08294169,0.048231084,-0.08133223,0.0104175825,-0.073176146,-0.053394247,0.0062298947,0.009087622,0.00352721,-0.0014463888,-0.00783335,-0.0034942422,-0.01387167,-0.112339675,0.046808995,0.06825402,0.022584857,-0.017873097,-0.014926311,-0.0252525,0.027970165,-0.10708115,-0.05730982,-0.03657352,0.042033575,-0.056037854,-0.04198546,0.08156223,-0.027988594,0.030110952,0.019588392,0.07196406,-0.047508545,-0.065153904,-0.07891418,-0.035329856,-0.028458863,-0.102293976,0.008028601,-0.06751161,0.04807981,-0.0073010647,0.18339378,0.053842444 +3.4.23.41,"In peptidase family A1 of pepsin, and weakly inhibited by pepstatin. Can partially substitute for kexin in a deficient strain of yeast. The homologous product of the Mkc7 gene (Saccharomyces cerevisiae) has similar catalytic activity and has been termed yapsin 2 [2]",384,1.0,-0.0611271,-0.07254397,-0.05872738,-0.013957654,0.0698379,0.054021005,-0.017727947,0.038270585,0.050542448,-0.0029886325,0.009451965,-0.01820125,-0.113306746,0.073425815,-0.015089702,-0.008415701,-0.041668817,0.020279706,0.026115295,-0.11607311,0.029409911,0.018564077,0.05415612,0.10735829,-0.026685886,0.02446992,0.09669688,0.06419408,0.006536603,-0.115320794,-0.015718775,-0.071800426,0.04658047,-0.03317921,0.037676007,0.02961796,0.08241321,-0.039824646,0.029165398,-0.06519678,0.018006722,-0.04378371,-0.08914375,0.021667486,0.00048174933,0.002728027,-0.04449286,0.054788947,0.044048715,-0.032851096,-0.085460104,-0.08675132,0.013190231,-0.049768556,0.074436955,-0.0053607514,-0.055205107,-0.0655418,0.0866955,0.006881485,-0.012075697,-0.027291356,0.058931075,-0.038783014,0.021896549,-0.086591356,0.0031766319,0.011286707,0.012815573,0.03208952,0.03941803,-0.10218529,-0.00051386806,0.044415105,0.020095682,0.030690884,0.009436871,-0.07329106,-0.051461305,-0.0027960571,0.068072,0.0412156,0.10735171,0.078577146,-0.016862702,-0.098259315,-0.0038614227,0.012989064,0.034528486,0.015342165,0.04075251,-0.024238741,0.10665671,-0.04151473,-0.012370167,0.0059170583,-0.038192365,-0.022155572,-0.003907077,-0.014541313,-0.0013038152,0.06723298,-0.038726877,-0.06378045,0.051853653,0.08313909,-0.03357313,0.07634057,0.07703062,-0.01996213,-0.0012339521,-0.0044771954,-0.0009330497,0.022350674,-0.063264504,0.0025503903,0.048888512,0.031666026,-0.017353011,0.06698979,0.01408654,0.049874235,0.01347673,0.05896894,-0.100719936,0.025581192,-0.09552164,2.3448728e-33,-0.010399216,-0.06969655,-0.02191748,0.021076111,0.0015976777,-0.049358323,-0.017505452,-0.026599078,-0.01557433,-0.13056909,-0.06702398,-0.09033106,-0.05420869,0.02267627,-0.044236377,-0.006642859,-0.024218963,-0.03418674,0.0359743,0.021885714,-0.038526613,0.021126369,-0.02155711,0.0006317944,0.10066833,0.03951432,0.010351792,0.060835462,0.08653649,-0.027312674,-0.018574795,0.02439916,-0.051724523,0.033859186,0.029620294,-0.0039528743,0.03542929,-0.014986263,-0.014285347,0.079675205,-0.0825046,0.03571371,-0.024104752,-0.09673442,0.027044604,0.009094756,-0.010229883,0.043032788,0.018955119,0.017023033,0.065768026,-0.00536418,-0.013951531,-0.033033073,0.020572001,0.004684973,-0.025341885,-0.0033150245,0.059236035,0.007860695,-0.0037502255,0.011481334,-0.007096415,0.0065712593,-0.017223585,-0.010986361,-0.07833185,-0.019093495,-0.062149238,0.0917988,-0.032337755,0.054849066,0.085703745,0.023323698,0.00015854387,-0.12028491,-0.06207204,-0.0013077685,-0.032949034,0.069130756,0.00566552,-0.028567547,-0.03570968,0.03510658,-0.068977684,-0.027186671,-0.023884594,-0.011459552,-0.06372107,0.012459936,-0.07578785,-0.059888214,-0.06636511,0.07202542,-0.058769908,-4.8668218e-33,0.09682874,-0.06812015,0.09011071,-0.030382868,-0.12922503,0.06749002,0.028768498,-0.058438104,-0.006047093,-0.03725883,0.043273132,-0.051790427,0.05594888,0.008822025,0.030673511,0.045360748,-0.071260095,0.034171503,-0.09157118,-0.027325965,-0.012563781,0.050133448,-0.028376967,0.11590042,0.0931758,-0.020012354,0.014763514,0.13976544,0.03368305,-0.023624951,-0.01648146,-0.03516738,-0.060684234,-0.031811826,-0.030363388,0.016452909,-0.04407635,0.02759371,-0.048364904,-0.022013055,-0.003819726,0.081206135,-0.032526277,0.060207162,-0.043826617,0.052678213,0.0771427,-0.0068967254,0.028412769,-0.05819942,0.0049835346,-0.0034480044,-0.08685732,0.059470404,-0.009972633,-0.01521252,0.005333089,0.05913848,0.045866974,-0.009591165,0.011690864,-0.05526569,0.054514583,-0.013551442,0.08337495,-0.035165787,-0.043807745,0.010793625,0.091630325,-0.014087213,0.08354787,0.0052368874,0.06973819,0.046379346,-0.012866971,-0.0065473886,-0.10185242,-0.03980408,-0.012483925,-0.028602513,-0.017621795,0.01399612,-0.011952155,-0.0010288223,0.03919718,0.00068384886,0.100584246,0.13957939,0.04183088,0.059927493,0.071548596,-0.015495634,-0.027650137,0.06654869,0.0072771385,-3.6497312e-08,0.080015205,-0.08184662,0.029865745,-0.04749611,-0.041089367,0.030716402,-0.037099775,-0.0048096376,-0.02099621,-0.017921057,-0.016934603,0.10394722,-0.0052080685,0.08448822,-0.0022359008,0.011124941,-0.026377924,0.048934307,0.048513092,-0.024193622,-0.08496764,-0.009976002,-0.064159065,0.07428762,-0.053313453,-0.06263504,-0.012164637,0.07668064,-0.0006375515,-0.10632405,-0.026405295,0.001298323,0.0077079553,-0.06744284,0.02378964,0.03226599,-0.027986653,-0.025277773,-0.012030759,-0.012587441,-0.021191463,-0.056964595,-0.045288924,-0.032090444,-0.0723332,-0.022216998,0.05652691,0.039808817,-0.021752983,0.05361932,0.06874523,-0.01519033,-0.034523144,-0.00730379,-0.03218892,0.005902113,-0.029166143,-0.065460585,-0.013004465,-0.09117823,0.05268618,-0.03172804,0.12859628,-0.05292261 +3.4.23.42,From the thermophilic archaeon Sulfolobus acidocaldarius. Maximally active at pH 2 and 90 _degree_C. Weakly inhibited by pepstatin but shows no sequence similarity to pepsin. Type example of peptidase family A5.,384,0.99999994,-0.07764621,-0.09244609,-0.08365927,-0.021361735,0.0036096275,0.09978194,-0.041098285,0.010445615,0.049631465,-0.02768085,0.05970984,-0.07055262,-0.01637206,0.07185284,-0.048284728,-0.01568977,-0.055943035,-0.035251442,-0.006007704,-0.09659248,0.04100799,0.04049282,0.0004332529,0.0713541,-0.08585983,0.028497284,0.052836943,0.0063251653,-0.03156993,-0.038177904,0.008718322,-0.04225911,0.1347717,0.0033436,0.033632018,0.058606755,-0.056716595,-0.06036464,0.06606527,-0.004969586,0.070360765,0.016743978,0.0190788,-0.02321103,-0.036629897,-0.050351806,-0.025948036,0.019256705,0.050539337,-0.04248338,-0.059183188,-0.034126468,-0.013781796,-0.043334913,-0.0012126362,0.050631188,-0.007889314,-0.02915364,0.062827095,-0.04119966,0.035590377,0.06632002,-0.02566772,-0.008899094,-0.07516834,-0.016001258,0.035118766,-0.055347003,0.039808095,0.03669093,-0.06317231,-0.022813799,-0.019817399,0.030465983,-0.050772972,0.075624034,0.034778483,-0.09219861,-0.10105634,-0.07984081,0.0069465884,-0.08108272,0.019591939,0.08245851,-0.061646175,-0.036277536,0.061853092,-0.008872706,0.040896527,-0.030659111,0.054637574,-0.048162654,0.06425198,-0.053153403,-0.052050672,-0.009342663,-0.00074208155,-0.062352084,-0.030728023,-0.01930036,0.044558614,0.030334717,-0.082185656,-0.06619584,0.01482443,0.028754469,-0.05960362,0.04296437,0.10174103,0.015734062,-0.027591558,-0.03804681,0.019726872,-0.06001254,-0.033319272,0.0120409215,-0.014071544,-0.03637387,-0.025307043,0.027872562,-0.013219776,-0.021438835,0.024856446,0.025284654,-0.08338986,0.02795459,-0.111486726,3.7711666e-33,0.057078905,-0.0678041,0.08860219,0.014808463,0.036114395,-0.009338215,-0.088401295,-0.007147868,0.03877823,-0.099520095,-0.0152330045,-0.0031290806,-0.0022059837,0.0150943175,-0.060085516,0.07385378,-0.0258317,-0.042685073,-0.036898013,0.08529784,-0.06880188,0.08749066,0.0033739589,-0.049277127,0.066599935,0.060232006,0.049304377,0.028324794,0.071447425,0.0052167797,-0.011746207,-0.072304554,-0.13378166,0.061966468,0.06879877,0.030272545,0.015003455,-0.011943514,0.0018875119,0.01945727,-0.014490379,0.039204523,0.026016127,-0.016462881,0.092262484,-0.01350594,-0.05002826,0.086653456,-0.009021708,0.050023027,0.0076970323,-0.03842206,0.03856852,0.0011848435,-0.0689242,-0.022911707,0.0016162047,0.063483484,0.044653047,0.033883654,0.08509667,0.04137832,-0.05148247,-0.014756624,-0.05277916,0.088439725,-0.12427965,-0.041432366,0.04287382,0.069701076,-0.017569024,0.06198722,0.033901114,0.049431164,0.0100279525,-0.040489506,-0.011202425,-0.009490521,-0.049694885,0.08832682,-0.047105994,-0.0627523,0.08643707,0.026911523,-0.10251653,-0.028484534,0.010122666,0.026351593,-0.07040493,0.02258276,-0.020060515,-0.056085095,-0.014201778,0.10532177,-0.011596171,-5.029986e-33,0.096040756,-0.062297657,0.017879698,-0.07899163,-0.0645108,0.01932897,-0.00042124247,0.052314352,-0.049966667,-0.076552115,0.06390593,0.043135777,0.050398502,-0.06982811,0.067165434,0.07176186,0.039547842,0.047339782,-0.038983237,0.039033547,-0.058865193,0.022737408,-0.050596792,0.041571643,0.0478,0.009115798,-0.02634489,0.06533884,0.0055770273,-0.038115438,-0.03957831,0.05488718,-0.06607667,-0.054149233,-0.07247461,-0.016242754,-0.044969138,-0.003564759,0.008220269,-0.0020398267,-0.033993013,0.056501705,0.020865288,0.124462016,0.06286031,0.050294418,-0.03897908,-0.05041668,0.024577456,0.009319575,0.009570222,-0.08448266,-0.0018869877,0.030655215,0.05896764,-0.04740409,-0.015351029,0.0837391,-0.02261935,-0.03565121,-0.006174154,-0.023699518,0.04073719,0.018573035,0.0008947183,0.043010943,-0.054546483,0.010021101,0.102134064,-0.054503333,0.0790855,-0.0040722103,0.042760797,0.015728295,-0.020856557,0.028481908,-0.06420906,-0.007209504,0.010910952,0.0050891503,-0.06450827,0.084386915,-0.026826842,-0.009844418,0.028048465,-0.015044293,0.05865265,0.034740757,0.009587361,0.05327536,0.051300135,-0.031624243,0.029313272,0.019286131,0.017707255,-3.2197637e-08,0.07488216,-0.05234758,0.032099385,-0.011333239,-0.06596363,0.044140294,-0.008181128,-0.020764649,0.023546819,-0.024736226,0.0010316613,0.052825358,0.023734413,0.12987357,-0.032714993,0.047945887,-0.010990187,0.014980658,0.0059490423,0.028377978,-0.14519557,0.0076930434,-0.051962826,0.027695527,-0.019986909,-0.060008064,0.012593115,-0.068048745,-0.049679983,-0.047767356,-0.056929495,-0.022025067,-0.040230807,-0.09499267,0.06007415,0.07250255,-0.006922698,-0.026619492,-0.056277797,-0.00033866664,0.06672468,-0.04124763,-0.048143115,-0.009619586,0.07035885,-0.058314383,0.03526351,0.047673486,0.00087514374,0.036844138,0.05028989,0.04538504,-0.03396025,-0.07884368,-0.106777884,-0.06031389,0.024271864,-0.07863908,-0.024451507,-0.021209888,0.081295334,-0.041287486,0.08695315,0.05386888 +3.4.23.43,"Many species of bacteria carry pili on their cell surfaces. These are virulence determinants in pathogenic strains, and are assembled biosynthetically from type IV prepilin subunits. Before assembly, the prepilin molecules require proteolytic processing, which is done by the prepilin peptidase. Prepilin peptidase and its homologues play a central role not only in type IV pilus biogenesis but also in transport of macromolecules across cell membranes. Although both peptide-bond hydrolysis and N-methylation are catalysed by the same molecule, the methylation can be inhibited without affecting peptidase activity, and it is believed that the enzyme has two separate catalytic sites. Type example of peptidase family A24.",384,1.0,-0.055140126,-0.09100339,-0.1221664,-0.0790224,0.034698848,0.054334775,-0.03269922,0.06015059,0.06923692,0.003677552,0.06506559,0.030790566,0.004274993,0.069162145,-0.025822543,0.018085044,-0.1167146,-0.009287394,-0.008209226,0.018867314,0.062506065,0.009550041,-0.10923043,0.00027197538,-0.09185813,-0.030692939,0.041162286,-0.046525173,0.04906472,-0.036193524,-0.040420216,-0.023520652,0.021683667,-0.028794385,0.057758264,0.09304411,-0.024565147,-0.030458177,0.118336216,-0.04324319,0.095425956,0.037945405,-0.019604504,-0.09643454,0.031651165,-0.0408438,0.02363608,-0.017682292,0.019910328,-0.09434059,-0.056134082,-0.012435107,0.016528638,0.0047791465,-0.035211988,0.051929306,-0.087202266,-0.07444148,0.05295101,0.021657575,-0.051742792,0.013253331,-0.0023644404,-0.03475469,-0.029995918,-0.06016016,0.013136232,-0.05253016,0.009477069,0.010555631,-0.040085927,-0.018564422,-0.056533653,0.060340267,0.01769901,0.06947282,0.011882692,-0.011325575,-0.10727965,-0.04073873,0.0011974854,0.017215904,0.06993537,0.076221794,0.043558374,0.017058408,0.019974142,0.03530824,0.07626657,0.03660865,-0.0012374696,0.03602687,0.07816131,0.036950186,-0.07830439,-0.014550687,0.0026693193,-0.025381867,0.06552239,0.00082492473,0.03236001,-0.0030681137,-0.06532236,0.0054878374,0.016700352,-0.010291846,0.059498537,0.08950687,-0.014571277,0.054330796,0.03680302,0.011386937,0.06429565,-0.06189751,-0.08453048,0.05882128,-0.0130646955,-0.029605713,0.030494101,-0.010539032,0.03170741,-0.03688336,0.051903185,0.041633334,-0.062483728,-0.05035456,-0.13518865,3.974443e-33,0.03555907,-0.053575467,0.027317889,0.049196023,-0.018455997,0.0036058235,-0.04078558,-0.08725213,0.037895173,-0.11531986,-0.058116004,-0.044003487,-0.06424032,0.058602355,-0.05945271,0.009946602,-0.0017735213,-0.025095567,-0.0050763474,0.011341541,0.0032939953,-0.017441517,-0.015147651,-0.04379259,0.09745827,-0.004553895,0.030149268,-0.09230059,0.041811146,-0.01945098,-0.01831501,-0.087577075,-0.053634264,0.06450574,0.05510156,0.033477753,-0.034960944,-0.011676733,5.5276967e-05,0.102236785,-0.039174564,0.04802326,-0.026911484,-0.02362637,0.08126107,0.006929214,-0.057089657,0.0580359,-0.05436293,0.016405622,0.015443589,0.020741157,0.05645882,-0.019846383,-0.10516667,-0.064696155,0.038070217,-0.0411849,0.043907642,0.040544204,0.014648081,0.028657487,-0.021247556,0.022706522,-0.015311499,-0.020746268,-0.09401758,-0.03161051,0.08465526,0.09382457,-0.10545267,0.02133832,0.06862967,0.013369573,0.041336276,-0.09983572,-0.06845999,0.023792922,0.026503226,0.0732378,0.0392522,0.058345236,0.05925936,0.011803178,-0.1122319,-0.067078196,0.017781882,-0.007236335,-0.046430252,-0.04610437,0.052083056,-0.04896785,-0.019135963,0.0618953,-0.08876312,-5.9840953e-33,0.0738802,-0.039617337,0.08281734,-0.087846085,-0.094959445,0.068812534,0.0049081,-0.036549855,0.012466084,-0.05690482,-0.0055518886,0.019224713,0.036316074,0.010925484,0.012156117,0.06601284,-0.04050215,0.048777208,-0.047566175,-0.021326443,-0.12840109,0.026377873,0.010707572,0.05047238,0.0022958105,0.005765455,-0.04088902,0.05582023,-0.009606453,0.032394204,-0.025177473,0.026729796,-0.03300619,-0.039259814,-0.05581963,0.08023995,-0.033927802,-0.028950326,0.029718297,-0.019570373,0.009883381,-0.009707651,0.028056638,0.01110472,-0.039500773,0.06525976,0.0066469028,-0.008693142,0.0008769928,-0.0333331,0.025861498,-0.0066461796,0.027530631,0.01439231,0.069675595,-0.060277645,0.0628382,0.036370393,-0.048421018,-0.03168069,-0.024625305,-0.08509361,0.033783976,0.02768664,-0.03925021,0.02827085,0.032917548,-0.0058672745,0.07808362,-0.014366997,-0.012825595,0.091147035,0.01664149,-0.018190563,-0.024889674,0.028715858,-0.056493435,-0.09792135,-0.04077813,0.04052446,-0.053802975,-0.019417368,-0.04525136,-0.047589246,0.021277245,-0.02265217,0.08910354,0.041027866,-0.03157823,0.03443846,0.038020566,-0.01039588,0.034717087,0.034867257,0.016476428,-4.2877303e-08,0.087375805,-0.073840566,-0.0015468588,-0.029367153,-0.10798907,0.03796525,-0.031901494,-0.04490274,0.04376337,-0.04511673,-0.026227145,0.0066177766,-0.0075019286,0.028244957,0.044098202,0.118928894,-0.09566045,0.011033527,-0.013052046,0.005062267,-0.10132669,0.031139648,-0.099499546,0.03589795,0.04635453,-0.040298164,0.008924448,0.0040529426,-0.06722421,-0.00746046,0.033739705,0.03935954,-0.022031983,-0.012342347,0.020695357,0.02341783,0.027285434,-0.048787992,0.002298334,0.019582482,0.099128954,-0.02415067,-0.12165691,-0.00740385,0.06589514,0.02226641,-0.055544134,0.011889803,-0.026307777,0.026394213,0.043704655,0.047828414,0.0417169,-0.028139263,-0.049946696,0.045101292,0.0013610682,-0.047595553,0.021310488,-0.0010091772,0.030626575,0.019450383,0.20013537,-0.022462811 +3.4.23.44,"A single aspartic residue is critical for activity, and inhibition by EDTA indicates that a metal ion is also important. The enzyme is known from several nodaviruses that are pathogens of insects. Type example of peptidase family A6, and structurally related to the tetravirus endopeptidase in family A21, although in that family, the catalytic residue is thought to be Glu.",384,1.0,-0.07029945,-0.022318808,-0.07488839,0.007963943,0.095723405,0.062458724,0.0050050006,0.076991044,0.016852599,0.024689222,0.031325042,-0.024228,-0.060333684,0.017103238,-0.07421525,-0.05375991,-0.05930132,-0.07408412,-0.037882574,-0.084199995,0.049355574,0.084478766,-0.021484584,-0.0380001,-0.034938045,0.024955144,-0.046287376,-0.0545266,0.07264458,-0.09331173,-0.015751451,-0.032126423,0.049763314,-0.031021532,0.06853279,0.025795558,-0.055224087,0.03200688,0.023326954,-0.046965566,0.104413964,0.081006005,0.034049157,-0.044612527,-0.0016523884,-0.09266658,-0.016578808,0.0649301,0.07966635,-0.0042184256,0.06158343,-0.07426204,-0.027153818,0.00432452,-0.03657649,-0.011006585,0.010622207,-0.047475744,-0.0067537106,-0.0024189628,0.07336581,0.03370622,0.00058933545,-0.05848133,0.034611482,-0.09279083,0.041930564,-0.077963226,0.009255703,0.023651443,-0.05389528,-0.06413122,-0.11638451,0.09470691,-0.005938962,0.061315462,0.038827736,-0.09955764,-0.031491887,0.021763304,-0.002741645,-0.020067105,0.1531996,0.07757326,0.02219533,0.017685806,-0.03367394,-0.009532962,0.083322175,0.028901093,0.05869607,-0.038008798,0.06588905,-0.03799708,0.010502296,0.050826237,0.039444864,-0.04689905,0.016775975,0.03260829,-0.006471771,-0.02324761,-0.089762606,-0.04528088,-0.05210422,0.042352002,-0.007997178,0.0085166795,0.071233,-0.024511144,-0.014761336,-0.014422577,0.030212712,6.363854e-05,-0.04814921,-0.015334388,-0.008314496,-0.07838217,-0.03254832,-0.00997883,0.07412992,-0.009454788,0.014948135,0.08648266,0.0045041796,0.012983621,-0.13078459,1.1253868e-33,-0.010315562,0.005096254,0.007551306,-0.0041112425,-0.0063083936,0.011795815,-0.048740067,0.009867488,-0.006461282,-0.045202788,-0.08850699,-0.044836096,0.057728954,0.021755027,-0.03243799,0.02420131,-0.008949515,0.025785943,0.03335251,-0.0066226944,0.019966196,0.02314979,-0.006850449,-0.014423746,0.121295296,0.08196438,-0.06388622,-0.009259095,0.033848975,-0.009372856,0.02478625,-0.0213333,-0.08492858,0.06727129,0.042699892,-0.015652398,0.002869395,-0.06887608,-0.034926105,-0.03017494,0.0467925,0.058651727,-0.08849591,-0.01074621,0.070612624,-0.08032953,-0.026416948,0.06885104,-0.0036397101,0.017202007,0.01762219,0.033692893,0.081959754,-0.020822141,-0.063747115,0.062020082,-0.01820063,0.020748504,0.06339097,0.02310949,0.053341545,0.018230591,-0.055193845,0.00813864,-0.0063110488,0.014325039,0.0020692777,-0.016601969,0.014841756,0.07114815,-0.08115233,0.027365135,0.07292897,0.02924254,0.008009687,-0.078083985,-0.08181693,0.056720424,0.018590659,0.03241319,-0.020677939,-0.0125179775,0.121803164,-0.04423076,-0.04581147,-0.05024806,-0.021099739,-0.01663239,-0.045125555,-0.0050235144,0.05868277,0.0257931,-0.078933656,0.018724296,-0.043865055,-2.473498e-33,0.001307494,-0.0375232,-0.005823697,-0.054277625,-0.042039417,0.04858786,0.027292108,-0.07243279,0.049570914,-0.019238358,0.06107617,0.0062487177,0.0007893468,-0.085592285,0.0691253,0.019062478,-0.007581982,0.10414635,0.02238476,-0.06503275,-0.04821709,0.013449386,0.040237322,-0.04271292,0.021835448,-0.02477639,-0.051834676,-0.010088564,-0.03800374,0.02534072,0.026111621,0.05923466,0.03389446,-0.06523691,-0.033717953,0.019911796,-0.0671422,-0.07380704,0.032694064,0.03678727,0.05398253,0.07648569,0.108840466,0.06724612,-0.0031592923,0.04606897,-0.042897303,0.10662222,-0.004287585,-0.081037536,0.06647421,-0.0625852,0.0022591818,0.03793673,0.070750706,0.046872105,0.0784754,-0.009964201,-0.01966634,0.052681506,0.020097127,0.010074359,-0.046934247,0.010118421,0.047691707,0.014028474,-0.030343402,0.049928844,0.046373844,-0.025518358,0.08647926,-0.009694194,0.0071044154,-0.008458423,-0.07000822,-0.044547245,0.037295673,-0.04180298,0.032086875,-0.0793762,-0.0953886,0.05923191,-0.0023763147,-0.00085961353,0.059635174,-0.064115375,-0.0834296,0.12235859,-0.002821995,0.08085393,-0.058875643,-0.0761263,0.06902474,0.08712572,0.06495667,-3.7775486e-08,0.05477804,-0.04599539,-0.010370017,-0.10756864,-0.038130254,0.010387912,-0.034542117,-0.010731476,0.021078981,-0.004666211,0.08331284,-0.026528396,0.004007058,0.0011687669,0.028368518,0.05258756,-0.021996532,0.08207444,-0.07072703,0.004981589,-0.07079312,0.028772691,-0.115562156,-0.04031549,-0.042091362,-0.04632075,0.047595713,0.06629972,-0.043164596,-0.01710535,-0.08307813,0.043708622,-0.012854764,-0.041075718,-0.026395995,0.024664752,0.06106302,-0.07124904,0.022477264,0.01479512,0.024058593,-0.03609101,-0.04531986,-0.044683605,-0.0054762284,0.021072086,-0.019057387,-0.013297622,0.0035906434,0.009949446,-0.0034612303,-0.0026381472,-0.04105961,-0.026823541,-0.099393226,-0.030335875,0.0007166652,-0.08201224,0.062750064,-0.09505155,0.094607435,-0.011927562,0.12758406,0.02320214 +3.4.23.45,"Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain.",384,1.0,-0.023646533,-0.120745786,-0.06828404,-0.03963922,0.016321002,0.030013883,0.02039152,0.028101023,0.077186994,0.002456939,0.010731833,0.029648624,-0.009743899,0.06605208,0.03378673,0.051631182,-0.14043337,-0.0058895373,0.06478524,0.041467164,-0.009432688,0.01907652,-0.02316973,0.015917744,-0.030476036,0.045805868,0.076368645,-0.08423206,0.04854403,0.03712536,-0.01634274,-0.08439679,-0.011005095,0.0320927,0.016888088,-0.007866932,-0.0810107,-0.007690489,-0.034548894,-0.001327094,0.04731803,0.024094367,-0.030773595,-0.0362194,0.033684473,-0.03460667,0.0144633865,0.04221533,0.04496102,-0.059480377,0.003724679,-0.057657998,0.018716086,0.0016467574,0.009942023,0.108199194,-0.08160356,-0.016202202,0.06432684,0.033649854,-0.08916662,0.009564444,0.08048557,-0.031572536,0.042283967,-0.041793853,-0.06369474,-0.036616318,-0.049807847,0.028462816,0.027085345,0.009947976,-0.03379051,0.049152482,0.0647352,0.049907446,-0.029542692,0.050409075,-0.029720984,-0.039489917,0.005469025,0.0070010773,0.10658025,0.03371186,0.10732616,0.007956793,0.092186876,0.034540188,-0.053480733,-0.0022458201,0.041181695,-0.087483354,0.014402957,0.030220728,-0.080040015,-0.017632328,0.022267414,-0.046986356,0.008293245,0.000990173,-0.05540722,0.043793656,-0.0056834915,-0.049946662,-0.0021282965,0.11375496,0.044069897,0.06117052,-0.030623619,0.018481102,0.041450806,-0.028948052,0.06630325,-0.004768029,-0.016572429,-0.033928413,-0.049554825,-0.0018107592,0.05352724,0.012784286,0.052196883,-0.016721766,-0.032545015,0.04657791,-0.045173533,0.07732232,-0.11778382,1.3855242e-33,0.028887792,-0.023234794,0.012626601,0.032700486,-0.061876453,-0.0043636602,-0.07091329,-0.048172906,0.0475911,-0.07013398,-0.029056119,-0.079229444,-0.02404588,0.09928628,0.019601345,0.031289138,-0.04918976,0.039004054,0.07271523,-0.03823332,-0.088732034,0.05550083,-0.019243851,-0.11807354,0.080938235,-0.052040126,-0.008985011,-0.0052741203,0.09870415,0.026883893,-0.07523838,-0.028972032,-0.10576902,-0.029350773,-0.0046825297,0.047466367,0.0831128,-0.03496098,-0.11989313,0.065217674,0.080108725,-0.0227106,-0.07748024,-0.010249667,0.035182595,-0.05886559,0.0738914,0.04766871,-0.05955113,0.011846941,-0.017175548,0.0048313965,-0.040436767,0.009121904,-0.05673797,-0.026867127,-0.030906014,-0.0678944,0.08484902,0.0020996144,0.03803834,0.0377155,-0.06022791,0.006168859,-0.01957755,0.0044996548,0.010344929,-0.06244174,-0.026933508,0.0037528956,0.03520469,-0.021444201,0.032340992,0.03448803,0.018113822,-0.08008528,-0.020145994,0.020133128,0.055502467,-0.059153214,0.003462429,-0.007688306,0.010867992,0.010943601,0.023360427,0.020287829,0.09233565,0.021492803,-0.13335063,-0.044597246,0.012558166,-0.0054700198,0.010444903,0.0767836,-0.0831285,-2.762804e-33,-0.07047835,-0.13350703,0.07573515,-0.10565022,-0.05511049,0.05370328,0.02841368,-0.08337805,0.036571782,-0.079242654,-0.0170467,-0.006794198,-0.010811104,-0.058825828,0.05061363,-0.038464744,-0.104370676,0.0035793472,-0.0008600756,-0.033734135,-0.04024996,0.025912585,0.017284263,0.06388604,-0.043562945,0.039408512,-0.015417239,0.09680117,0.016031248,0.0074362583,-0.058043696,0.04982238,-0.0143096065,0.004364625,-0.06905315,0.010204216,0.0040991106,-0.056858636,-0.0092855245,-0.045150217,-0.00023030218,0.045570277,-0.020789051,0.01727421,0.03259254,0.04286163,0.052646924,0.0012561133,0.029187903,-0.0054478613,0.016185246,-0.063182764,0.0057092984,-0.018764954,-0.02735816,-0.023093924,-0.039761256,0.0016207412,0.021215169,-0.020803094,-0.012318494,-0.020022687,0.02823906,0.020052664,0.11763129,0.0008079254,-0.014943226,0.07313072,-0.03303386,-0.011544004,-0.014099635,0.015325081,0.015897168,0.069932595,0.10064998,0.037444994,-0.07111792,-0.049858786,0.037250686,0.014396836,-0.10658235,0.046830297,-0.06604232,-0.0077569014,0.06020785,0.0030384366,0.03342239,0.006708191,0.004349465,0.04058922,-0.0021546423,-0.017440548,0.05317534,0.0799771,-0.027154332,-3.5436063e-08,0.08360313,-0.00994423,0.011422516,-0.05039064,-0.0646956,-0.09270088,0.016031342,-0.03509473,-0.060145747,-0.030045101,-0.06710696,0.0593157,-0.00038281406,0.09719736,0.021340089,0.10250026,-0.0021645245,0.018731052,-0.012464816,-0.080893725,-0.017005127,0.06347714,0.023766913,0.026478812,-0.009676123,-0.08258531,0.03348548,0.02687313,-0.10341825,0.0068288343,-0.027140405,0.054641005,-0.015282555,0.017838525,0.08615484,-0.015737053,0.055642206,0.011402453,-0.037979115,0.002797016,0.07981128,-0.06904418,-0.011084704,-0.06652749,0.036328137,-0.009436142,-0.005538937,0.052510563,-0.010794321,-0.035673663,0.05907691,0.010775789,-0.0096559655,-0.06069198,-0.050542552,-0.034679245,-0.0548076,-0.034164194,0.057011258,-0.111894585,0.026042502,0.037419807,0.19643521,0.055058427 +3.4.23.46,"Suggested to be the major ""beta-secretase"" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.",384,0.99999994,-0.067194626,-0.07714866,-0.08811798,-0.021211267,0.016237892,0.044507794,0.0060049,0.04916325,0.080400206,0.02325249,0.04208721,0.025898712,-0.025154851,0.038130317,-0.005976573,0.03463794,-0.14733598,-0.057633694,0.018738825,-0.053482335,-0.0012588211,0.021897694,-0.0024705338,0.020930855,-0.04571913,0.017861385,0.0502154,-0.105512485,0.010637519,0.008716286,-0.0126614915,-0.08605399,0.030558933,0.024179319,0.01295114,-0.005437671,-0.06650507,-0.034282975,-0.023099141,-0.01837627,0.07604181,0.024661023,-0.016207425,-0.021088347,0.013815432,-0.016302565,0.020866575,0.079241924,0.08180902,-0.07939299,0.0006745559,-0.073280044,-0.018496864,0.056958143,-0.01603915,0.10140509,-0.04081256,-0.040213328,0.051219996,0.07218422,-0.06327319,0.039894514,0.023861358,-0.02725299,0.00267035,-0.056642428,-0.016596371,-0.051156674,-0.03016334,-0.0049321633,0.01232502,-0.051507875,-0.057535883,0.029049296,0.06567252,0.003326409,-0.074559905,0.008872869,-0.048629448,-0.027415577,0.05779456,-0.02471273,0.1129352,0.040198337,0.0982044,-0.00676033,0.10012352,-0.027367096,0.004738943,0.002903476,0.005065271,-0.15310536,0.010904763,0.024404725,-0.08003965,-0.038092006,0.028816672,-0.04577342,-0.018006766,0.015276637,-0.030110313,0.020454098,0.020237511,-0.052739892,-0.032273214,0.10392568,0.011306313,0.07540186,0.042687744,0.017145041,0.030933669,-0.033215906,0.03716632,-0.0044608866,-0.011438724,0.0016055352,-0.02668692,0.013032443,0.023726016,0.03197597,0.031188866,0.0022421095,-0.024826007,0.042632192,-0.050390277,0.071871795,-0.16516308,-1.1533353e-33,0.0046987636,0.0041715475,0.011749271,0.031608626,-0.06995598,0.028026558,-0.109403335,-0.06798746,0.05973653,-0.012690989,-0.04838393,-0.10291626,-0.0636519,0.073419265,-0.0041718483,0.033140704,-0.044102248,0.03982203,0.06668697,-0.034323893,-0.083171174,0.07748258,-0.041438695,-0.1288438,0.13519222,-0.034730833,-0.0040495,-0.0020230936,0.09207906,0.019054435,-0.060977157,-0.021306595,-0.10076166,-0.011226504,0.006630699,0.03876362,0.062410362,-0.08612599,-0.05287579,0.0075578243,0.022030586,-0.031148626,-0.063806355,-0.019600742,0.04717934,-0.038930133,0.04543613,0.049159724,0.019382823,0.04334059,-0.005435073,-0.022587635,0.027316872,-0.004784379,-0.07166071,-0.028638184,-1.3549044e-05,-0.042977642,0.09017593,0.018236786,0.045506414,0.024657128,-0.0693422,0.014610213,-0.04058841,0.016425658,-0.015863635,-0.058609348,-0.005035613,0.04525493,-0.03870025,-0.012858336,0.08643748,0.022334754,0.0019840957,-0.05467462,-0.045163054,0.0075790198,0.03832512,-0.04563782,-0.017124025,-0.014671644,0.024026914,0.04297234,-0.04451761,0.019519778,0.073464766,0.020140724,-0.1429797,-0.0039368924,0.056582756,0.026613643,0.014444497,0.10479003,-0.04382123,-1.5779526e-33,-0.035159837,-0.11815719,0.059572794,-0.14547218,-0.016359696,0.01736979,0.0085268,-0.006680591,0.06260632,-0.056104615,-0.018410563,0.025412532,-0.03482945,-0.073071115,0.048101153,-0.038418923,-0.032834675,0.042417534,-0.009530376,-0.056095358,-0.051694453,0.047483202,0.024037048,0.06630425,-0.04821795,0.012111951,-0.008225833,0.10466789,0.054606773,0.03514227,-0.08253416,0.06411252,-0.005506794,0.0021040475,-0.08119851,0.008118736,0.020813541,-0.061242253,-0.01844464,-0.033942413,0.011083289,0.06415728,0.0017096543,0.07587932,0.025315277,0.090775974,0.05524025,0.045660324,0.019655852,-0.03582253,0.006215367,-0.06267507,0.015145637,0.012749077,0.0009837744,-0.009205278,-0.014319663,0.020468455,-0.020296281,-0.008647442,0.0060183425,0.008576325,0.025796602,0.045449123,0.09090795,0.011682851,-0.02433358,0.050849814,0.023468362,0.033308003,0.017680349,0.027401466,-0.015422071,0.04870209,0.012521361,0.006011017,-0.10357284,-0.08199777,0.052339,0.013713829,-0.09004185,0.025995431,-0.0637205,0.0019886007,0.0376325,-0.03809238,0.04001061,0.049862675,0.009338349,0.04798666,0.019625112,-0.0044349525,0.013469783,0.061154377,-0.025423082,-3.577353e-08,0.11166102,-0.027683267,0.015007449,-0.097171456,-0.04361149,-0.06884832,0.021183265,0.021827526,-0.0028207665,-0.0031789613,-0.042751703,0.07303282,-0.005614561,0.04860552,0.020038644,0.06616108,-0.049133785,0.057216614,-0.022265742,-0.041994877,-0.021868125,0.037357822,0.012229222,-0.021001177,-0.03966282,-0.09845012,0.04939973,0.09317636,-0.114284985,0.01857817,-0.010013333,0.03051018,-0.0359397,0.007546454,0.019000037,0.020638512,0.05397705,-0.014979901,0.009220474,-0.0071732453,0.043057345,-0.09403333,0.004446709,-0.023434428,0.021023672,0.008097407,0.038010735,0.011247839,-0.008505947,-0.022640927,0.053349987,0.021491593,-0.0334024,-0.059444893,-0.078085914,-0.014221232,-0.08698419,-0.045840606,0.03160874,-0.09936896,0.040187627,0.028572885,0.18887435,0.05412122 +3.4.23.47,In peptidase family A2. Responsible for the post-translational processing of the human immunodeficiency virus polyprotein.,384,0.99999994,-0.0009202248,-0.019683719,-0.05641996,-0.113681115,0.03392123,0.018984655,0.05230126,0.04408352,0.09530439,0.06927303,0.054986846,0.027577655,0.015097753,0.0015515477,-0.027965058,-0.022281045,-0.097301796,0.021457078,-0.0038460162,-0.092218034,0.05095304,0.025159696,0.01497539,-0.018155864,-0.07771514,0.063452154,-0.014915719,-0.015404152,0.043285824,0.0026155086,-0.037931547,-0.062731355,0.08790341,-0.019420464,0.03283674,0.03279828,-0.048794977,-0.040772505,0.09954479,-0.025972828,0.07805586,0.008620565,-0.028718099,-0.011354875,0.018773481,-0.03264476,-0.011112787,0.09147399,0.08312675,0.03498178,-0.009680535,-0.056412045,-0.026180822,-0.015396659,-0.00838364,0.071608886,-0.085427426,-0.017612528,0.07882208,0.043693446,0.006934666,0.10582633,0.055553406,0.035517816,-0.008969186,-0.031552177,0.06414437,0.03996061,-0.040714666,0.023527505,0.0021941685,0.034130946,-0.1239482,0.12416703,-0.017558599,-0.023970572,-0.020237392,-0.08435122,-0.049064454,0.02143861,0.008341539,0.04664112,0.12528244,0.02006069,-0.014680112,0.02026034,0.03256709,0.004906829,0.015893547,-0.039764192,-0.022580527,-0.08042157,0.036342166,0.040398713,-0.038100906,-0.029148012,0.023248643,0.001822546,0.0120101925,0.01986164,-0.012714107,-0.029532554,-0.023403492,-0.05105735,-0.047859143,0.040581048,-0.018996,0.037059132,0.016137736,-0.013217434,0.0017618213,-0.019377485,0.01992024,-0.033885654,0.032916367,0.0019092626,-0.015331971,0.04620862,0.03523196,-0.085090265,-0.024291132,0.048608195,0.057517532,0.036625408,-0.032589383,-0.071501724,-0.044442415,-2.0728412e-33,-0.05287756,0.0015134127,0.09568456,0.09019807,-0.057458863,0.060401767,0.06690456,-0.03761555,0.015745364,-0.0633234,-0.062221043,-0.13572556,-0.023127193,0.048098713,-0.09656809,0.013108482,0.028149284,0.032904517,-0.03097709,0.087297074,0.04020063,0.08158563,0.045035392,-0.073822215,0.042948507,0.031116983,0.027471533,-0.018619737,0.036337875,-0.0299476,-0.13371594,0.08393548,-0.094400935,-0.016423171,-0.029167742,-0.05480518,0.106811404,-0.05927813,-0.030005429,0.07037306,0.029070865,-0.019189142,0.0006823097,-0.08367097,0.050374426,0.01889666,-0.031265695,-0.01646162,0.00078400085,-0.0077538877,-0.033301223,0.023061505,0.015512243,0.052177325,-0.09644733,-0.012752618,-0.0028729227,0.03549178,0.052654542,0.023268256,0.04947207,-0.028042855,-0.02199925,0.05383563,-0.013502878,-0.04009529,-0.052812714,-0.005026088,0.022009576,0.100791305,-0.038149625,-0.063496314,0.050425272,-0.0021762254,0.13594621,-0.07542093,-0.14683086,-0.015303639,0.025521725,0.039125457,-0.08470142,0.032429196,0.07570011,-0.03796401,-0.042461205,-0.042612653,0.05496336,0.008416099,-0.059350282,0.036669288,0.031538136,-0.0051362626,-0.064759426,0.05570241,-0.052336745,-1.1384374e-33,0.040259037,-0.03224616,0.05675114,-0.03179745,-0.091554455,0.043088187,0.130128,0.0033419009,0.06977616,-0.037317615,0.03814044,-0.042884488,-0.004876163,-0.040556155,0.07450004,0.017575879,0.003885141,0.05719311,-0.038586117,0.061496716,-0.09627711,-0.016373927,0.008810001,0.0005484661,0.059020255,-0.05502074,0.0151337,0.061981652,0.0043877596,-0.019892905,-0.06253922,0.040293753,-0.039998204,-0.0076668477,-0.015752789,-0.008866369,-0.021940973,-0.00803248,-0.027533878,-0.038493443,-0.00089327095,0.09279282,-0.015328302,0.11361047,-0.0191376,0.13169068,0.01860642,0.03221877,0.012465978,-0.011883338,-0.012625896,-0.0417616,0.0008845897,0.011747664,0.026189614,-0.06458352,-0.04382807,0.051303755,-0.002808208,-0.00022609043,-0.01899225,-0.0149827665,0.022408893,0.0203309,0.06762012,0.04968907,-0.021505896,-0.014418525,0.10769172,-0.029276885,0.017578209,-0.060683634,0.01505773,-0.012633771,0.015247575,-0.026119752,-0.1124204,-0.078381,-0.018223664,-0.04332928,-0.03522112,-0.08685968,-0.036908664,0.010997741,0.012175878,-0.021952039,0.02245045,0.021351177,0.015343548,0.10180982,0.041354682,-0.026281351,0.0042447057,0.04415314,-0.043801647,-2.4604244e-08,0.0098551465,-0.01997256,0.011110984,-0.09450487,-0.04496717,0.028001439,-0.09955477,-0.010101607,0.048564006,-0.030695604,-0.02948125,-0.09750533,-0.0020178743,0.016415922,0.01485752,0.09171458,-0.041961826,0.109132625,0.010124439,0.0075318296,-0.08453532,0.041868076,-0.09347785,0.0063244263,-0.021918966,0.00082959427,-0.0055505624,-0.013466924,0.03758852,-0.079267,-0.0091391,0.0056366776,-0.040364567,-0.0057693557,0.04024927,0.036969703,0.014178761,-0.025887016,0.07736194,-0.039019912,0.09085971,-0.046267018,-0.053621836,-0.03280342,0.029225128,-0.040074196,-0.089961864,0.016543379,-0.0142820645,-0.05169906,0.03999049,0.022226665,-0.07123932,-0.055140853,-0.07907773,0.02278556,-0.04471731,-0.07538463,0.03399035,-0.06980045,-0.019111235,-0.02753184,0.108784944,-0.018802723 +3.4.23.48,In peptidase family A26. From the bacterium Yersinia pestis that causes plague.,384,1.0,-0.014722879,0.0072129266,-0.04443675,-0.032120246,-0.017397355,0.02693366,0.011127626,0.03039707,0.036007747,0.06255635,0.04579966,-0.007126223,0.008772647,0.005896058,-0.098420285,-0.042935517,-0.06988675,-0.05913721,-0.04161121,-0.07388386,0.020559873,0.079367585,0.030490275,0.0011683381,-0.10094742,0.035240002,-0.007029673,0.045123644,0.07927474,-0.023623757,-0.027223378,-0.012541844,0.00022679413,-0.041236863,0.023900462,-0.014579368,0.11753911,0.018599844,0.13285461,-0.0072263097,0.026794856,0.040041633,0.006955801,0.0034005838,-0.008184382,0.010420351,-0.056867287,0.13673149,0.1279778,-0.0974078,-0.046082396,-0.04956305,-0.0291821,0.06567007,0.032610178,-0.032875635,-0.036412567,-0.06512288,0.01502711,0.03591977,-0.043764308,0.03057146,-0.02940302,0.005215458,-0.053510405,-0.0563739,0.025157012,0.052413054,-0.019695632,0.06638616,0.0028069096,0.00077867514,0.0030232472,0.10728819,0.010531371,0.026436916,-0.021125933,-0.082834125,-0.043824963,-0.0486801,-0.037180357,0.026749851,0.12995218,0.11130365,0.027280442,-0.01544731,0.029972168,-0.008923801,0.042846166,0.010760363,0.030309997,-0.06418045,0.05457021,-0.019513234,-0.09230996,0.01661012,0.04505742,-0.065914504,0.04924262,0.021856876,-0.061469242,-0.103179365,-0.043897837,0.04078817,-0.051876865,0.047136202,-0.102450915,0.018256687,0.061000764,-0.0012081974,-0.08820264,0.03714359,-0.040492907,-0.03641828,-0.037367355,-0.046265673,-0.011937739,-0.06238799,-0.015465875,-0.060786262,-0.00087609474,0.008679919,-0.047937825,0.03641561,-0.04942087,0.0182263,-0.085199885,2.1474796e-34,0.08980736,-0.017664704,0.098488934,0.018647512,-0.025043195,-0.017198132,-0.0759799,0.009930837,0.08356358,-0.07269328,-0.048866913,-0.17915957,-0.055160042,0.0076917126,-0.018214257,0.054972176,-0.05438163,0.028747547,-0.028180018,0.003030872,-0.05409543,0.040857542,-0.0037439123,-0.091623306,0.031351943,0.03669386,0.00048542,-0.025037922,0.07275453,0.032269496,0.024114477,0.031446178,-0.058181323,-0.0005678098,0.012775109,0.002648771,-0.007950265,-0.030768238,0.008248308,0.08580927,0.04516395,0.055190746,-0.032812167,-0.022136386,0.07678329,-0.042707253,-0.019696012,0.0128375925,0.040210996,0.055827297,0.0118826,0.0029192185,0.06760747,0.01832501,-0.014139769,-0.022770861,0.06556347,0.007639546,0.06668579,0.052259896,0.09897465,0.034321245,-0.0033571008,0.046104882,0.00843477,-0.030928157,0.024393745,0.007178163,-0.029186768,0.08398418,-0.037465315,-0.002568466,-0.035209145,0.022374045,0.01219909,-0.05508132,-0.021341385,0.007998026,-0.019058196,-0.005002113,-0.024046756,-0.014099604,0.023200098,0.009174061,-0.09788332,0.042656347,0.033406485,-0.016020501,-0.061951436,0.012178437,0.030775247,-0.017929234,-0.01067537,0.031343546,-0.113343835,-2.6224124e-33,0.011085761,-0.048642013,0.023450894,-0.053689227,-0.07403444,0.001892001,0.018330436,0.054790672,0.07656676,0.013339655,0.013183665,0.026556842,0.042405896,0.029634718,0.0043333345,0.008965721,0.056635328,0.057608694,-0.06901558,-0.04245958,-0.05999795,-0.023825586,-0.03191973,-0.074296504,-0.008989527,0.019904923,0.01571219,0.094755456,-0.063028224,-0.06515733,0.0048023155,0.005205419,-0.06404065,-0.030582119,-0.021377642,0.043198355,0.02645028,-0.02652416,-0.05658,-0.059368346,0.030694412,0.084072344,0.043005634,0.16049442,0.02420498,0.07664755,-0.005489768,0.07130508,0.051933877,-0.010911525,0.0033486024,-0.040844984,0.060175225,0.046997625,0.013895628,-0.11397224,-0.016105529,-0.028359622,-0.044575017,0.005028153,-0.0074329576,0.0025363537,-0.09685766,0.033954665,0.05051323,-0.0019209523,-0.038936157,0.029631155,0.068467155,-0.022660386,0.01711589,0.040071946,-0.05127346,-0.032416906,-0.07175809,0.069672175,-0.026727337,-0.09334989,-0.0074922647,0.01353679,-0.05816715,0.009069476,-0.01358769,-0.034682874,-0.050372217,-0.05442463,0.03841186,0.037979178,0.0069128857,0.050552018,-0.01939782,-0.034979165,0.042142596,-0.017306434,0.032942567,-2.2426342e-08,0.08462876,-0.04337401,0.024101954,-0.033634,-0.015260994,-0.034174964,-0.011670346,0.054938752,0.10002708,0.013375433,-0.07216136,0.09023205,0.051640023,0.005061887,-0.012548744,0.001926878,-0.063788526,-0.011864409,-0.02766081,-0.05649547,-0.03606442,-0.01416662,-0.009915071,-0.06560026,0.01822067,-0.053242784,0.044004016,-0.05714642,-0.040146515,-0.03906661,0.014941926,0.002083293,-0.023000997,-0.06830911,0.03515198,0.027589587,0.0015596794,0.0068455404,0.032644592,-0.12055439,0.11456488,-0.03554959,-0.043455984,-0.044636343,0.062818296,0.034928,-0.060763106,0.08014881,-0.025033442,-0.09231075,0.021449871,0.044666987,0.067796856,-0.019241944,-0.14408918,-0.055132184,-0.024285985,-0.05190294,0.042309053,-0.057553418,0.06612524,0.0057387254,0.13055173,0.11679668 +3.4.24.1,"A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins in the venom of western diamondback rattlesnake. The 60 kDa hemorrhagic toxin 1 of Crotalus ruber ruber shows identical specificity [2]. In peptidase family M12 (astacin family). Related metalloendopeptidases from rattlesnake venoms are EC 3.4.24.41 (atrolysin B), EC 3.4.24.42 (atrolysin C), EC 3.4.24.43 (atroxase), EC 3.4.24.44 (atrolysin E), EC 3.4.24.45 (atrolysin F), EC 3.4.24.46 (adamalysin), EC 3.4.24.47 (horrilysin), and EC 3.4.24.48 (ruberlysin)",384,1.0,-0.0614711,-0.038323026,-0.08326687,0.046271376,0.045623798,0.028396592,-0.005183877,0.05431309,-0.018546658,-0.05398325,0.0030970834,-0.103701085,0.05422764,0.06621495,-0.09523523,-0.025861464,0.00024000967,-0.015490564,-0.0076700286,-0.02708741,0.020935452,0.061054237,0.02665313,0.055260442,-0.05602063,-0.0069797267,-0.052996553,-0.043649588,-0.0014115795,-0.094783925,0.010428383,-0.06609748,-0.039222796,-0.12517731,0.09945031,-0.0663485,-0.073767886,0.028266137,0.048924576,0.003337086,0.046017077,0.088973455,-0.0124163,-0.0056399065,-0.055814847,-0.047035012,0.03578786,0.039423775,0.05754579,-0.0007869599,0.04479468,-0.04147106,-0.06470556,0.0017292483,0.031257294,-0.068837464,-0.078499794,-0.05528945,0.08016268,0.0251496,0.057922088,0.017754633,0.05430181,-0.010480474,-0.03584319,-0.044969387,0.0019545208,-0.024575096,0.037439972,-0.008596407,0.026975287,-0.050731335,-0.024377294,0.09443203,0.011277902,0.110771455,0.04273164,0.06739374,-0.088397734,-0.066313654,-0.08385062,0.025950545,0.1609001,-0.009893704,0.095423386,0.061362036,0.019974153,0.02863889,-0.04003768,0.07680933,0.13533574,0.02302393,0.031026484,-0.009819589,0.0007764556,0.008719288,0.060818117,0.103081346,-0.06999927,0.00783266,0.006937331,-0.022708695,-0.09568906,0.0026469948,0.059463765,-0.0024628784,-0.05328424,-0.008341246,0.06699808,-0.029127948,-0.0064785727,-0.016522476,0.0003175197,-0.05394725,0.07603422,0.0025764713,-0.011743713,0.0040357998,0.049781285,-0.0035955373,0.07408518,-0.042089563,-0.0011153484,-0.019575275,0.0786964,-0.024329945,-0.15286905,6.416628e-33,0.017469877,0.021030243,0.05681587,0.022219475,-0.020923922,-0.055601604,-0.12902714,0.0122436965,-0.00019401008,0.011547571,-0.08265022,-0.073488444,0.030129554,-0.03562843,-0.06517579,-0.005870605,-0.07683814,-0.0292463,-0.007148437,-0.10137861,-0.004859486,0.018171547,-0.06378749,0.018331887,0.005835876,0.06218653,-0.059878618,0.007847978,0.023297163,0.015442353,-0.0029067658,-0.12122899,-0.008779247,0.018010663,-0.050879274,-0.06383996,0.05153396,-0.072781734,-0.062338203,-0.033844955,0.0065648733,0.028257616,-0.10178925,0.015605259,0.08191624,-0.05525473,-0.036646046,0.049332395,0.004053845,0.018961933,-0.032109167,-0.027474018,0.17504911,0.05007512,-0.046513557,0.035144906,-0.011670958,-0.03276929,0.054453507,0.030409366,0.105679564,0.05563737,-0.020154592,-0.048164673,0.073154055,0.025620794,-0.021808805,-0.02158694,0.024887843,-0.023551239,-0.061438043,0.05008775,0.044573333,-0.013858523,0.03205335,-0.0450125,-0.045528714,0.035400327,-0.057994287,0.04164306,-0.072498366,-0.038184397,0.09143049,-0.041369192,-0.003061485,0.004284025,0.07698912,-0.09942279,0.0149956355,0.071259215,0.044200994,-0.005072667,-0.043739922,0.014434337,-0.03692157,-4.390585e-33,0.012706797,0.044822328,0.0862877,-0.02101317,-0.04054843,0.006025022,-0.019152926,0.056085773,0.03266862,-0.083110735,0.032792915,0.015288125,-0.0019785718,-0.029621983,0.03926477,0.039939106,0.0099143395,0.049853187,0.022068568,-0.010217677,-0.08347185,-0.0074336533,-0.024220724,-0.024363743,0.06579678,0.05422966,-0.021218684,-0.010352618,0.049921762,0.059488334,0.04608555,0.091585234,0.016747812,-0.0014660879,-0.11525606,-0.07440363,-0.055854086,-0.01650525,0.0404793,-0.0017904454,0.080565766,0.009504672,-0.030394034,0.027947504,0.044495177,0.088824116,-0.03023087,0.12886845,0.032486144,-0.04403621,0.02519871,0.008524272,-0.00016351603,0.07089753,0.059265103,-0.058236025,0.07095449,0.021237915,-0.019570686,0.014397429,0.019673686,0.012323187,-0.06288668,0.054380424,0.06938309,0.07394522,-0.04316081,0.046117738,0.011736268,0.005728515,0.017819718,-0.010868028,-0.009265937,-0.05402113,0.03789514,0.041578684,0.017195133,-0.04075109,0.003597315,-0.0063730953,-0.07348767,0.078573145,0.015733054,-0.027386414,0.02695491,-0.013870964,-0.030220766,0.073912755,0.055550314,-0.024163501,-0.0025546195,-0.043859337,0.05431177,0.022859054,0.0623273,-5.0687284e-08,0.039011743,0.007707991,-3.5426667e-05,-0.088592395,0.01928983,0.033743285,0.01818363,-0.023564033,-0.00876853,0.071043134,0.050695,-0.040397853,0.0279613,-0.057150714,0.034649413,0.031144598,-0.027091343,0.008601165,0.031020213,-0.0076137464,-0.00836801,0.0083263945,0.007516667,-0.0010861782,-0.014885208,-0.07262506,0.025628868,-0.011598597,0.002682311,0.008944228,0.01739087,-0.058600646,0.0064985934,-0.034057934,-0.030778097,0.016635746,-0.061923668,0.028029233,0.06158655,0.037881434,-0.018836776,-0.115937576,-0.043535125,-0.037808266,-0.06758454,-0.041319124,0.0018203335,0.024991255,-0.006297094,-0.113348044,0.04557959,0.008644424,-0.009410699,-0.10588866,-0.060873624,-0.013056259,0.013608483,-0.013013716,-0.04357414,-0.05661015,0.003144378,-0.05667723,0.12268623,0.02274336 +3.4.24.3,"Six species of metalloendopeptidase acting on native collagen can be isolated from the medium of Clostridium histolyticum. Class I has forms alpha (68 kDa), beta (115 kDa) and gamma (79 kDa); class II has delta (100 kDa), epsilon (110 kDa) and zeta (125 kDa). The two classes are immunologically crossreactive, but have significantly different sequences, and different specificities such that their actions on collagen are complementary. The enzymes also act as peptidyl-tripeptidases. Variants of the enzyme have been purified from Bacillus cereus [10], Empedobacter collagenolyticum [4], Pseudomonas marinoglutinosa [1], and species of Vibrio, Vibrio B-30 (ATCC 21250) [2] and V. alginolyticus (previously Achromobacter iophagus) [3,8]. Also known from Streptomyces sp. [9]. The Vibrio enzyme is the type example of peptidase family M9.",384,0.99999994,-0.05369557,-0.09151137,-0.10485877,-0.02586826,0.042643677,0.03741424,-0.06782089,0.12678547,-0.015133698,-0.045997728,0.01804666,-0.07149016,0.029452574,0.10744369,-0.088880785,-0.066328876,0.030660825,-0.03998375,0.01610738,0.032721993,0.086217105,0.05056301,-0.032671176,-0.04054612,-0.034107193,0.03581808,0.027789691,-0.042026933,-0.024960035,-0.025497777,-0.008373039,-0.09115322,-0.0119255455,-0.007985916,0.13812998,-0.02998518,-0.05114889,-0.02364853,0.10308411,0.03026817,0.022182496,0.044730604,-0.00085467735,-0.042772356,0.009306885,-0.022914693,0.06479754,0.07557132,0.027475096,0.019668907,-0.0396344,-0.10095132,0.0008439029,0.05819713,-0.049032222,-0.00998717,-0.055172168,-0.08541063,0.044541642,-0.0011291308,-0.024999006,0.0030377286,0.086464494,0.003090487,-0.07744665,-0.025641758,0.0023101855,0.021596594,0.026012542,0.008108642,-0.045704175,-0.018885463,0.035629507,0.07868477,0.047367845,0.074393496,0.032060895,-0.0277027,-0.020012807,-0.080940746,-0.052015617,0.034648683,0.086329296,0.0057852897,0.020096997,0.003047238,0.08252946,0.013243397,0.029723097,0.003918177,0.08841009,0.007954109,0.02322817,-0.094312444,-0.019928908,0.055602435,-0.017101448,0.02465866,0.05263895,-0.029676061,-0.030988572,-0.021414386,0.01743047,-0.056552064,0.012073307,0.028957749,-0.007881688,0.07880947,0.12842676,-0.024563262,-0.0327846,0.019149011,-0.024507806,-0.0105925985,0.07189181,0.0070672254,0.058246166,-0.042066928,-0.057000715,0.0048825545,0.032552216,-0.076746,0.060631067,-0.028240656,-0.031704284,0.09119155,-0.050280754,4.2315846e-33,-0.007096965,0.016760074,0.014408398,-0.04825724,0.039136432,0.007659964,-0.053636782,0.04408907,-0.040997766,-0.03152643,-0.0953224,-0.080328315,0.05601728,-0.015857572,-0.040292446,0.06610911,-0.047898706,-0.007534625,0.037232682,-0.0023102756,0.0984373,0.06855942,0.024889456,0.013877968,0.0594015,0.09342829,0.018672042,-0.030185824,0.026479898,-0.026729243,-0.000647793,-0.06405629,-0.052951,-0.025111403,0.07935413,-0.036272705,-0.021941768,-0.059812948,-0.042619254,-0.0032778198,0.00616785,0.0128099015,-0.077769324,-0.026121387,0.10398494,-0.06846558,-0.039852418,0.10236017,-0.018332388,-0.009107926,0.032265984,0.00041221757,0.08754243,-0.06221751,-0.06119284,0.005708605,-0.007773538,0.07873822,0.1348489,0.006236913,0.081223145,0.059820317,-0.016033947,-0.008905692,0.009586002,-0.01703233,-0.06603624,0.064639926,-0.011519619,0.041866455,-0.053429984,-0.013943904,-0.050029837,0.0013769749,0.053407315,-0.101539545,-0.016528469,-0.021703595,-0.0144876465,-0.015381445,-0.03800657,0.027378442,0.039071858,-0.03890511,-0.045064624,-0.049196336,-0.04489496,-0.0032495295,-0.011257568,0.009037022,0.080934465,-0.018233646,-0.05182179,0.0873053,-0.065683566,-3.9394412e-33,0.0949389,-0.046295438,0.03896207,-0.040073223,-0.0794958,0.0460048,-0.0046727643,0.069794126,0.036369365,-0.063259944,0.046091277,0.006032357,0.015411586,-0.066468254,-0.004479342,0.08368061,-0.01831798,0.057280604,-0.02435085,-0.024331491,-0.033016663,0.06128027,0.037429724,-0.03253401,0.06474953,0.038599964,-0.022378987,0.101474404,0.023365844,0.070343405,0.04424531,0.072374955,0.01847216,-0.08607838,-0.11571612,0.008316018,-0.051194448,-0.05940438,0.11770903,0.012960373,0.05069006,-0.0022411016,0.010187527,0.08024478,-0.022423575,0.099179074,-0.075730376,0.016996853,-0.002317163,-0.024507502,-0.010148065,-0.05610261,0.0126034515,0.019010555,0.025349803,0.0065452056,0.01752102,0.0502283,-0.05180225,-0.00791357,-0.01804565,0.012364422,0.033340134,0.06276852,0.10233596,0.06526044,-0.022242598,0.068952054,0.017607547,-0.054890644,0.005736477,0.02869626,-0.015487751,-0.020590363,0.018199911,0.04140497,-0.024821255,-0.03114828,-0.02603316,0.022727793,-0.027698703,-0.02009345,0.033388283,-0.059480757,-0.003443395,-0.012728173,0.0348414,0.106267616,0.027358636,0.0027824612,-0.004244905,-0.10507024,0.017799165,0.017445836,0.051752433,-4.960139e-08,0.025248133,-0.055732604,0.08917432,-0.06458051,-0.003084374,-0.055428203,-0.058058023,-0.028926069,0.02033926,-0.025288923,0.036835033,-0.046957742,-0.022226816,0.0025520995,0.044005472,0.044363547,-0.063143805,-0.007933094,-0.002519668,0.045174003,-0.070989676,-0.068874896,-0.021945093,0.093106255,0.042052392,-0.06466901,0.009542264,-0.006308168,-0.08568184,-0.020937728,-0.054083448,0.014677963,-0.03864382,-0.0048836335,-0.07711763,0.0019812007,-0.04174568,-0.008250751,-0.0036610102,-0.009120106,0.070067376,-0.072204106,-0.04619902,-0.05676267,-0.009065103,-0.014950196,-0.022554984,0.018207086,0.009272165,-0.07620369,-0.0149670355,-0.049708795,-0.026237123,-0.0116150165,-0.08016506,0.0038713545,0.035240572,-0.11342664,-0.049151592,-0.05854872,-0.00018755722,-0.056222066,0.19028968,0.029449355 +3.4.24.6,From the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma).,384,1.0,-0.07228502,0.05074968,-0.0722382,0.042024646,0.0044023274,-0.06887657,0.008317235,0.033049088,0.023463665,-0.028659187,0.025649156,-0.033674303,0.076868914,0.053624485,-0.10123291,0.052697673,0.037068777,-0.017890608,0.098283954,0.03342547,0.038375195,0.06616418,0.054444026,-0.018918537,-0.018360661,-0.0047028847,-0.056385767,0.0110595375,0.043603893,-0.051214445,-0.04098009,-0.035279807,0.019440804,-0.10856726,0.047157157,-0.05589427,0.030613378,0.06600821,0.10740672,0.10065062,0.01607565,0.06531511,0.030161412,0.037345693,-0.069215305,0.0070599653,-0.0684984,0.023597104,0.0673268,-0.0007737848,0.019775622,-0.029872954,-0.11171162,0.029595844,0.019968437,-0.11215007,-0.049036507,-0.058214966,0.016033744,0.0145791555,0.056577623,0.018990586,-0.007468684,0.076707736,-0.056153215,-0.0725436,0.0038949149,-0.01251859,0.007817535,-0.06301534,0.053061172,-0.025578534,-0.013285677,0.03156689,-0.032406356,0.009192324,0.09122687,0.026683573,0.02857286,0.077823274,-0.018693961,0.043554846,0.09824851,-0.0043511004,0.056762837,0.031594664,0.04676352,0.044572532,-0.010491171,-0.021235183,0.032869462,0.0017138785,-0.064417206,0.0051423856,-0.00076055276,0.019053489,-0.0062810695,0.060881972,-0.05185942,0.07089958,0.039073456,-0.13652143,0.008112187,-0.014876373,0.028835224,-0.0010895137,-0.05605922,0.044908985,0.059588887,-0.021637833,-0.020228876,0.040875975,-0.00084592536,-0.0068111946,0.021304278,-0.00096870685,-0.026684994,0.027327353,0.024146123,-0.004336506,0.057158835,-0.021163747,-0.028644172,-0.0078010447,-0.0014387588,0.019352447,-0.14347546,3.2817308e-33,0.036896814,-0.072525054,0.048060816,-0.069440514,-0.036269914,-0.022379959,-0.045071885,-0.07734006,-0.034048747,0.042478945,-0.020466886,-0.065163516,0.0052705826,0.008809241,-0.11582822,-0.013518311,-0.050396677,-0.0018501817,-0.0019203015,-0.077706076,0.051810693,0.06186254,-0.0061024344,-0.010459402,0.013656583,0.015009322,-0.08271868,-0.04627466,0.03490894,0.03691149,-0.0061423634,-0.1369178,0.0065776906,0.017616257,-0.030487072,-0.052677806,0.0053288075,-0.1328682,-0.012046449,-0.03409835,0.042380266,0.014934935,-0.009508277,0.024062907,0.0064375205,0.0029566193,-0.03164321,0.1010168,0.031015791,0.036343146,-0.018871237,-0.034643978,0.06992654,0.004941751,-0.10339361,0.014599203,-0.019707605,-0.09977458,-0.059035633,-0.009437026,0.03615196,0.05178071,0.0356004,-0.02899428,0.0507081,-0.076015815,-0.060105763,-0.016689077,0.027113548,-0.02381541,-0.0043867044,-0.021036796,-0.029170945,-0.059990346,-0.017422553,-0.05280308,0.060080364,0.032783248,-0.09456568,0.05962689,0.000539551,-0.021847282,0.046054125,-0.008756184,0.0026056233,0.066432916,-0.008865682,-0.13503982,0.07165074,0.08232228,0.029514523,-0.027333668,-0.071631715,-0.039054044,-0.03129921,-2.4827682e-33,-0.0022998422,-0.0005096794,0.100340776,-0.0116930865,-0.047192045,-0.0017771786,0.006503672,0.11800264,-0.029438607,-0.015749728,-0.07415966,0.07922947,0.031712804,0.015386131,0.03564838,0.018866703,0.0753707,0.05231341,0.055302475,-0.04457612,-0.07046128,0.035210047,-0.032891948,-0.08548505,0.07526192,0.04170771,0.034144167,-0.011375015,-0.007024134,-0.046582777,-0.026530491,0.0511828,0.009925076,0.023177767,-0.051842798,-0.015176054,0.005132744,-0.039575625,-0.011271647,-0.06148482,0.016809246,0.023369035,0.022632476,0.049261093,0.033779006,0.013201403,0.0134744095,0.11463169,0.042750068,0.009822623,-0.009571566,0.03132134,0.08099387,0.02269983,0.014132089,-0.098567806,0.014143335,0.030767767,0.011751723,-0.0041823825,0.030409152,-0.030506453,-0.12851119,0.055497956,0.14025314,0.17186043,-0.01981066,0.01571776,-0.051852312,-0.031110609,0.010561532,0.045921616,-0.07224137,-0.08363498,0.017854987,0.09654332,-0.032950778,-0.045796417,-0.03583387,0.013076212,-0.02453952,0.0061525325,0.021053327,0.02316042,-0.05041723,-0.0003014793,-0.031228516,0.035425268,0.03785257,-0.04132924,-0.07741211,0.035293005,-0.027475774,0.007874031,0.028949514,-2.5837949e-08,-0.036642265,0.052424446,-0.02761254,-0.04642038,-0.01748643,0.07499326,0.028228732,-0.059632666,0.043970574,0.05429591,-0.010012599,0.021434322,0.081795745,-0.080285005,0.058160808,-0.03419056,-0.0074402853,0.011615071,0.018371416,-0.045527488,0.021035096,-0.0068061026,0.028633434,0.09066574,-0.069832295,-0.041234795,0.03388591,0.06360652,0.070881456,-0.0012379073,0.0016446079,0.000430343,-0.06353723,-0.10080449,-0.051835556,0.021227071,-0.08925878,-0.021713903,0.08220679,-0.008141005,0.06362554,0.035876572,0.0650028,0.033108838,-0.08872969,-0.05675408,-0.028631166,-0.024833778,0.040923763,-0.029101914,0.03636193,0.0039449707,-0.01952815,-0.0059913225,-0.07258688,-0.0756307,0.012699514,-0.015558361,-0.034170132,0.0026534463,-0.058424972,-0.027851177,0.1491207,0.05229002 +3.4.24.7,"The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, alpha-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10",384,1.0,-0.044887166,-0.123816274,-0.072352625,-0.06968832,0.00753147,0.004674159,-0.047539122,0.0978306,-0.02184754,-0.0012557285,0.017893925,0.04033512,-0.047392633,0.110685065,-0.045101456,-0.015994769,-0.089475445,-0.038117018,-0.0034991987,-0.04861239,0.036891483,0.017638361,-0.048049748,0.030338664,-0.0342335,-0.049807075,0.04710061,-0.060722344,0.05519729,-0.050195076,-0.011178033,-0.08498717,0.059426297,-0.005186599,0.12949279,-0.0024418077,-0.084900744,-0.03784624,0.049679983,0.011080686,0.1244733,-0.0086123785,0.018171476,-0.05801149,0.06511804,-0.018463798,0.013789801,0.055739872,0.05741758,0.020079749,-0.05724214,-0.111540824,-0.036806077,0.038332563,-0.014797771,0.04490089,-0.09443471,-0.043097675,0.07333036,0.04206542,-0.030534994,0.030253297,0.0071270503,-0.017522195,0.014340772,-0.047882713,0.039014325,-0.0007216934,-0.059759565,0.016659437,-0.0045550624,-0.014013338,-0.03492926,0.099842995,-0.026161168,0.010441161,-0.03855487,0.026585,-0.040530454,0.015782202,0.0034200333,0.004397,0.07246932,0.06997514,-0.02343406,-0.011759956,0.026794693,-0.009277559,0.007942884,-0.016184928,0.012032991,-0.048538696,0.021629926,-0.020234482,-0.036546208,-0.0065667336,0.031037362,0.03789389,0.047340695,0.009520382,0.0082295,-0.05736251,0.03291039,-0.01542047,-0.07565972,0.06024993,-0.04059534,0.06731673,0.08313901,0.06415817,-0.047144767,0.029819176,-0.0046054805,-0.053095646,-0.018348573,-0.0062481984,0.013544155,-0.011355526,0.09239522,-0.022051249,0.032803517,-0.012108969,0.1406264,0.018276658,-0.08758816,0.11060573,-0.07955385,7.1612897e-34,-0.0031988672,-0.039893705,0.040544514,0.014273086,-0.07279476,-0.011084311,-0.09440356,-0.01550825,-0.01916922,-0.07423381,-0.08795555,0.056227576,-0.0036424757,0.04322523,-0.060134336,0.068555,-0.012182977,-0.0031049827,-0.0026322883,0.05057118,0.042718004,0.11156207,0.017226888,0.007740409,0.08747906,0.0050817956,-0.010725884,-0.037835356,0.015101879,0.018624548,0.010292573,-0.050984595,-0.11263702,-0.0012240292,0.014426551,0.011026984,0.03395593,-0.07938316,-0.010694076,0.04161694,0.039625205,-0.048113957,0.026677443,-0.094657816,0.08958497,-0.03983038,-0.030811409,0.06997521,-0.063979186,-0.011651895,0.046238992,-0.014194856,-0.008890777,-0.010039487,-0.06515558,0.030896517,-0.009573303,0.0047227377,0.05615143,0.05346624,0.06549326,0.0199608,-0.021481572,0.060281087,-0.018957231,0.022712162,-0.113168314,0.016237296,0.011671632,0.07789666,-0.026918378,0.0014672125,0.0022575657,0.039641947,0.061890285,-0.13197532,-0.027386129,0.11045495,-0.0679135,0.032970477,0.0021012211,0.016268918,-0.0013090809,0.0016664895,-0.07817345,-0.018514188,0.034745052,-0.036751237,-0.05799784,-0.02926424,0.012121203,-0.03677898,-0.014048079,0.104734585,-0.024554962,-2.7145537e-33,0.069514304,-0.08809697,0.053634588,-0.040608212,-0.05551674,0.03488722,0.1076082,0.03955215,0.049035285,0.018293535,0.022352943,0.024377858,-0.041445497,-0.0679553,0.075389214,0.02064959,-0.020234086,-0.0005801769,-0.019936632,-0.06671072,-0.08751937,0.04424667,0.06549418,0.012348563,0.028180538,-0.011694171,-0.06732581,0.08749084,0.014835398,0.025253495,-0.07431115,0.046057083,0.028870394,-0.031906974,-0.07664753,0.022889217,-0.03397757,-0.033230428,-0.012564395,-0.03567592,8.8534005e-05,0.0559253,0.0001529593,0.051045407,-0.03241911,0.106863946,-0.04571966,0.022103341,0.010854677,-0.0073436266,0.0025255152,-0.04094464,0.048953492,0.0053922976,0.02998259,-0.025944995,0.029739833,0.07214941,-0.06745603,0.052445445,0.018455882,-0.027199196,0.014658477,0.009141297,0.0644879,-0.010068497,-0.091929294,-0.03803641,0.0008281651,0.04688511,0.040755507,-0.015262735,0.018259149,0.050578695,0.013362274,0.12778316,-0.0087742405,-0.044207793,-0.03312787,-0.057555426,-0.026968172,-0.018568505,-0.012973206,0.038098745,-0.03498582,-0.025417758,0.04344085,0.07391275,0.046226237,0.051854536,0.01579081,-0.018112509,0.016280217,0.06723753,0.007916495,-3.7477704e-08,0.05807368,-0.06382652,0.0142223975,-0.069702104,-0.06643031,-0.0098823495,-0.06423424,-0.046019405,0.06790928,-0.031711914,-0.060584743,0.04672182,0.018304119,0.048154525,0.015919821,0.06761565,-0.003147888,-0.02072106,-0.011666839,0.035097748,-0.10108338,-0.029069364,-0.049762625,0.025177611,-0.025646463,-0.096409015,-0.023608219,0.0717797,-0.11249559,0.059619587,-0.034514453,0.029442798,-0.035065614,-0.04103194,-0.022133535,0.11161052,0.020836268,-0.057608616,0.0023746088,-0.016625525,0.07270786,-0.0860289,0.013905862,-0.07413544,0.022440938,-0.008015262,-0.009080604,0.024194393,0.034571398,0.018604074,-0.055328153,0.008473236,-0.06504666,-0.074397914,-0.072645016,-0.03061395,-0.024117686,-0.0870897,0.056503702,-0.100860216,0.036896374,-0.012085145,0.17141004,0.023719715 +3.4.24.11,A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13,384,1.0,-0.10641292,-0.05362992,-0.06570096,-0.07441233,-0.061464895,0.033773467,0.04121503,0.14809045,0.05042293,0.037254333,0.03225831,0.08024762,-0.035663925,0.05009594,0.0015957757,0.0059633567,-0.041219834,-0.027207777,-0.07544103,-0.032364327,0.03250849,0.05564863,-0.050722618,0.023582222,-0.051793106,-0.089169055,-0.0052565658,-0.03627164,0.059945192,-0.020546133,-0.053241484,-0.07810671,0.07762599,-0.032497026,-0.0058960863,0.02627369,-0.014333943,-0.025218692,-0.026331184,-7.7196135e-05,0.013079845,0.021426473,-0.07252651,-0.09595177,-0.007949797,-0.013368065,-0.0087603545,0.0647964,0.06642986,0.07763069,-0.011150868,-0.0044813296,-0.015827764,0.049375165,-0.023937864,0.036808558,-0.10656962,0.020694198,0.049957506,0.03277084,-0.07100328,0.023276206,0.091943696,0.044977028,-0.058758713,-0.06551853,0.023063393,-0.0033145358,-0.04117382,0.06828257,0.024089716,-0.016063778,-0.026143122,0.00048319565,0.008101473,0.016406544,-0.013570972,-0.048587292,-0.039186813,0.00044954312,0.022913968,-0.008999728,0.07059883,0.08894195,-0.040288366,0.006662531,0.016538296,0.0009360246,0.02951392,0.008028294,0.04395042,-0.091874056,0.06470718,0.05844383,-0.076152146,-0.039208256,0.087117426,-0.123053096,-0.011284216,0.030160755,-0.03811159,-0.051525492,0.008827981,-0.0289877,-0.022343455,0.09012697,-0.053972695,-0.0032532683,0.033941593,0.028880473,0.020733155,0.0023431908,0.0028074814,-0.07747625,-0.036699995,-0.060110893,-0.010249102,-0.07823906,0.04417328,-0.06725486,0.033741742,-0.023802565,0.015956027,0.052249998,0.043994486,0.10632131,-0.029647637,3.6581436e-33,0.053392906,-0.051773824,0.044971302,0.01425989,-0.042317163,0.0072291796,-0.006957884,-0.057708073,-0.05781667,-0.092596926,-0.045445222,-0.026307054,-0.0072730016,0.039396834,-0.034966357,0.035487484,-0.05125351,-0.003733454,0.006111238,0.0057969983,-0.022094054,0.0062181843,0.034063086,-0.06945838,0.09229755,0.032390162,0.005270732,0.016709013,0.054810982,0.008368006,-0.015122838,-0.029690914,-0.067044295,0.009289298,-0.0078337565,0.04240247,-0.04316019,-0.06739784,0.023668338,0.051754903,0.015537638,-0.016720612,-0.032430068,-0.043652836,0.0672019,-0.029983306,-0.080604054,0.032637846,-0.08627103,-0.0119442325,0.0071888627,-0.03454115,0.022660794,0.040274844,-0.07467898,0.0045893076,-0.035682898,0.019925443,0.04159097,0.10478994,0.0752911,0.049928337,0.018796867,0.06636811,0.052815896,-0.01288227,-0.08055378,0.0014017448,0.0049791713,0.012386914,0.02813953,0.0043913466,0.07058323,0.051717527,0.028023181,-0.120490044,0.07300813,0.06471174,-0.042064354,0.13342206,0.09035533,0.0010564314,0.0034865492,0.035499755,-0.066021055,-0.042249423,0.045740236,-0.12637942,-0.07992095,-0.00831029,0.012596199,-0.045622148,-0.02764916,0.04521633,-0.09515518,-5.422096e-33,0.10546626,-0.054601535,0.17109852,-0.03018422,-0.019920431,0.007424553,0.03152023,0.050605033,-0.013130382,0.016276726,0.027203497,0.029942706,-0.005885433,-0.031882063,0.050665304,-0.024946282,0.027881121,0.0053947205,-0.040460955,-0.026578033,-0.052170254,-0.0873662,-0.04399645,0.023693021,-0.009606598,-0.051765043,-0.11150693,0.078475595,-0.004223285,-0.06350009,-0.058544066,0.052945755,-0.07717141,-0.040736716,-0.003565331,-0.008270377,-0.026944114,-0.016945878,0.058163602,-0.06419173,0.039579544,-0.0089873355,0.07715651,0.019152282,0.03094198,0.11195793,0.0022630806,-0.018664936,0.016988214,-0.0145663,-0.023236895,-0.026338477,0.027323987,0.11512752,0.12086188,-0.017239193,-0.011849136,0.009408465,0.030991614,0.024939964,0.037597496,-0.052949347,-0.017634891,0.050235525,0.048079636,0.034538973,-0.02534445,-0.08747309,0.07138043,-0.012867887,0.01270073,0.008987318,0.035873633,-0.059791837,-0.010662189,0.061989255,-0.115879506,-0.04864833,-0.0036334198,-0.0046020974,0.028647885,-0.07609259,-0.027598236,0.03364006,0.09686682,-0.026280716,0.025041346,0.0680417,0.036911912,0.04446371,0.0076190163,-0.02755161,0.020825477,0.05366255,0.015760954,-3.521883e-08,0.082154326,-0.09578842,-0.03435188,-0.15449522,-0.07287715,0.026312338,-0.0054555573,0.005762517,-0.016030742,-0.0026075465,-0.020266058,-0.0024314704,-0.0072841984,-0.034345068,-0.00086513296,0.15365249,-0.05485396,-0.008044404,0.016916847,0.04321645,-0.094200835,-0.037410162,-0.04717697,0.045262385,-0.036800656,-0.004899907,0.0031540499,0.01656333,-0.058055606,-0.044552855,-0.0135845365,0.0715411,-0.060157277,-0.018092118,0.02734171,-0.032828517,-0.0034744432,-0.022297919,0.0029492301,-0.0036403683,0.048598524,0.032529164,-0.007672818,-0.022621693,0.038105387,0.0030962802,-0.021855585,0.025245607,-0.028622061,-0.01457478,0.007823258,0.010514489,-0.008343403,-0.08138045,-0.11152376,-0.0029198432,-0.006774783,-0.006330478,-0.007047237,-0.02887536,0.0011977875,0.012496126,0.13184588,0.099538684 +3.4.24.12,A glycoprotein from various members of the class Echinoidea. Extracellular enzyme requiring Ca2+. In peptidase family M10 (interstitial collagenase family),384,1.0,-0.024279347,0.0024965743,-0.03667103,-0.057290114,0.0109407175,-0.017140944,-0.056308147,0.085023075,0.009231707,-0.016997607,0.08870692,-0.050150897,0.03128541,0.04546317,-0.043913912,-0.09275665,-0.042977393,-0.0131971985,-0.05046889,-0.09099659,0.060858555,0.05667824,-0.049134128,-0.015699226,0.021611825,-0.070123576,0.021087961,-0.022026531,0.0005587321,-0.049755417,-0.04708817,-0.08011781,0.068106435,-0.01514421,0.056860693,0.022368094,-0.0014255234,-0.049496163,0.04769788,0.029116182,0.060198087,0.04217777,-0.021335589,-0.0716821,0.03348059,-0.027779339,0.07641866,0.007227992,0.0334306,0.027013797,-0.047817174,-0.10406819,-0.020291487,0.04813213,0.027770456,0.0474982,-0.1162162,0.0023005754,0.0075039184,-0.008564567,0.023638267,-0.004531361,0.0587884,-0.02979141,-0.05110772,-0.08511396,0.06737814,0.024868166,-0.04179627,0.076651014,-0.026962515,-0.007960078,0.046982307,0.07423066,0.0003467683,0.025959313,-0.07380647,-0.027240016,0.019552121,0.026178738,-0.014827562,-0.021819467,0.011189872,0.022295045,-0.0048783985,0.010810404,0.12482389,0.0052383416,-0.082234,-0.045257743,0.046954527,-0.09687556,0.02693706,-0.018695544,-0.012674119,-0.0054202992,0.034822732,-0.022315579,-0.021622015,-0.053730328,-0.015439328,0.012738937,0.047787167,-0.06942445,-0.04254097,0.023660026,-0.053163175,0.061618704,0.053334568,0.006987035,-0.00437307,-0.054287534,-0.06544348,-0.03467176,-0.024568636,0.08289342,0.011926312,-0.05466384,-0.009036614,0.021146106,-0.006394951,-0.0038088395,0.025182726,0.029827029,-0.05254535,0.04636911,-0.06783061,2.98452e-33,-0.017961213,0.023712631,0.017047632,0.0052333293,-0.055758417,0.008685482,-0.048290193,0.03938369,-0.0025473125,-0.08765985,-0.09428672,0.030317614,0.01860064,0.0015287017,-0.025364883,0.04537167,-0.116497636,-0.05332735,0.050707847,0.0070635094,0.043232415,0.024578216,0.007433548,-0.07283136,0.058594726,0.03778219,0.018118136,-0.031669702,0.0831258,0.01850194,0.025518904,-0.068211235,-0.06711602,0.038581695,0.067026444,0.006232186,0.044224523,-0.06831939,-0.0029046205,0.027716048,-0.02912978,-0.0277239,0.05763713,-0.0665044,0.021610018,-0.017607694,-0.051298205,0.05400354,0.045349274,0.0016532543,0.014212183,-0.010376486,0.08478228,-0.0427385,-0.09474684,-0.0027604366,-0.046033867,-0.0069762445,-0.07392853,0.07404796,0.032725397,0.06563202,-0.016039506,0.06264376,-0.06458297,0.056462307,-0.11863498,0.016039422,-0.0038733047,0.0026874347,-0.019351523,-0.058187734,0.048743304,0.026937569,0.008150194,-0.07181017,0.034188934,0.06239575,-0.1024356,0.053294525,-0.036122475,-0.016099839,-0.0037002459,0.0013175397,-0.030276744,-0.0026264365,0.022589529,0.025997136,0.06136995,0.077591725,0.01163246,-0.009733734,-0.019423982,0.12315057,-0.059021723,-4.4177454e-33,0.13070373,-0.09854973,0.0926844,-0.028731553,-0.0048840214,0.07579921,0.05658684,0.025155833,0.040405333,0.03407392,-0.0065927077,0.012309005,0.031105338,-0.1062935,0.048103675,0.015467677,-0.025326457,0.003353575,-0.0040335115,-0.009936505,-0.043219913,0.009016215,0.03426451,-0.026790656,0.057773575,0.046777837,-0.027907534,0.004657408,-0.038949277,0.018521912,-0.054647267,0.019416556,-0.029925875,0.010342404,-0.112892605,0.034259878,-0.029688615,-0.062457703,0.021751853,-0.02076353,-0.009508539,0.046554785,-0.0055940696,0.1424003,0.0643968,0.027364373,0.0304949,0.084451415,-0.0698493,0.008227056,-0.025937779,-0.022511162,0.024474757,0.011289188,0.053414635,0.021601945,0.0114470655,0.07350804,0.0029039993,0.04072758,0.027969811,-0.023987144,-0.0397518,0.018389108,0.055065684,-0.012466456,-0.116756424,-0.011017539,0.030606708,0.10240485,0.07260018,-0.04306629,-0.030608246,0.007885953,-0.006714707,0.10541714,-0.09311035,-0.059000485,-0.029806148,-0.04765235,-0.04835833,0.020029444,0.007911736,0.016257461,0.034168318,-0.018656425,0.009493594,0.13816462,0.023299403,0.044182256,-0.022387587,-0.025921885,-0.028945142,0.10369402,0.038075566,-3.1191515e-08,0.04518752,-0.056150842,0.0008969268,-0.07437452,-0.025308207,-0.04509311,-0.016520167,0.04559504,0.06773286,-0.004630056,-0.011766507,-0.00835093,0.008946128,-0.02509377,-0.039534096,0.10977085,0.0052121184,0.05483181,-0.0033016333,0.03535914,-0.12107895,-0.080175385,-0.08789897,0.10502424,-0.01830715,-0.013372155,0.01949995,0.08822218,-0.127882,-0.018497158,-0.011458664,-0.011786983,-0.08552836,-0.05810406,-0.05030014,0.07143811,0.0010320729,0.0007796087,-0.067497656,-0.015090882,0.037353095,-0.05251468,0.01842764,-0.036984466,0.044437956,0.0030252156,0.011865384,-0.035779443,0.02810824,-0.002725771,-0.033372425,-0.049364164,0.016688855,-0.090681896,-0.13907702,-0.0019940543,-0.0018529439,-0.062343966,-0.003733875,-0.0060848733,-0.0078334175,0.07190338,0.19449736,0.048322193 +3.4.24.13,"A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC 3.4.21.72, IgA-specific serine endopeptidase)",384,0.99999994,-0.004338619,-0.076148264,-0.14923337,-0.03959724,0.048711814,0.09475288,-0.06349662,0.08248247,0.021371746,0.039693367,0.044698235,-0.01923694,-0.09175162,0.10149577,-0.04869204,-0.025767308,-0.08786469,-0.05637452,0.017838586,-0.034066822,0.086566746,0.0992641,0.009926088,-0.011131948,-0.06874586,0.00052979414,0.012389195,-0.069722325,0.046966106,-0.05917228,-0.018899625,-0.06489342,0.075391255,-0.043453287,0.14883327,0.019047657,-0.033639748,0.0012077948,0.06305909,-0.024892207,0.059083108,0.029666193,0.0009238466,-0.065143436,0.02516859,-0.048107475,-0.00081893953,0.09897532,0.04878454,-0.04580006,-0.002371764,-0.07018042,-0.06146132,0.0020099564,0.020425143,-0.030228706,-0.04222305,-0.057258107,0.05147107,0.031558063,0.044434786,0.017372817,0.04631106,-0.0648808,-0.004223465,-0.0435893,0.011478015,-0.047749415,0.024208197,-0.021240046,-0.07185953,-0.057704724,-0.057754852,0.13574603,-0.007219449,0.08387419,-0.03297384,-0.061154887,-0.04194612,-2.6862022e-05,-0.015948435,-0.005551165,0.03587566,0.062536225,0.058013253,-0.037574977,0.044740107,0.060316104,0.061950885,-0.00959801,0.04533695,-0.115167506,-0.0071580587,-0.019187167,-0.029176546,-0.04164166,-0.0395488,-0.0059133247,0.01801234,-0.026432266,-0.0033298624,-0.028835986,0.030634148,-0.045582812,-0.025302181,0.08228818,-0.04051623,0.016383974,0.07988598,-0.013490774,-0.061125793,0.028050795,-0.054476988,-0.0726992,0.060717877,-0.030615523,0.014191905,-0.035815645,-0.01073402,0.0057212627,0.03453869,-0.0018877372,0.086813115,0.050740223,-0.027371632,0.10355186,-0.102689184,2.8741805e-33,-0.009889212,0.018050427,0.0812665,-0.060973104,0.009530864,-0.024153186,-0.049424224,0.027216574,0.018517073,-0.042265695,-0.06404689,-0.07483039,0.020591745,0.0076640635,-0.010795381,0.035545174,-0.019325342,0.001782217,0.0061546564,0.0021270718,0.033213854,0.09954125,0.030222315,-0.04225235,0.110708736,0.039987523,0.03364179,-0.011265363,0.094058074,0.008987946,0.018593408,-0.08734099,-0.09043234,-0.007963061,0.039874397,-0.000108594846,0.0062565026,-0.09656462,0.031063206,0.029108593,-0.012526605,0.04002089,-0.026491815,0.016665699,0.06932057,-0.08274648,-0.0010548807,0.054689497,-0.0027359002,0.0067449277,-0.037892103,-0.046734974,0.030404255,-0.009795556,-0.02978615,0.0066348505,0.06414139,0.08783881,0.12160644,0.08738848,0.017900176,0.019523272,-0.058445565,0.018962206,0.016629972,0.0072547984,-0.077453665,0.01617227,-0.0261634,0.06571364,-0.07140259,0.017328054,0.031461522,-0.00053681864,0.0038190135,-0.13252388,-0.06653646,0.051444378,0.014475102,-0.004792422,0.021843996,0.050941397,-0.0011869217,0.013419452,-0.064850956,-0.01745672,-0.05706123,-0.048185527,-0.06829684,0.031911284,-0.0011979693,0.00039459084,-0.022149697,0.061458316,-0.040288612,-4.2327704e-33,0.03204766,-0.08488475,0.04585764,-0.04321913,-0.018962108,0.078717954,0.0623229,0.025441617,0.005127782,-0.052679345,0.09099648,-0.054709397,0.07744614,-0.038012907,-0.005267428,0.0069539514,-0.025325228,0.09037713,0.028218903,-0.03644599,-0.037752837,0.008570138,0.03337217,-0.037708163,0.06411044,0.042812623,-0.026281932,0.079378724,-0.048729897,-0.03431723,-0.0028661855,0.022590362,-0.009752564,-0.082214646,-0.11545443,0.001432295,-0.043052126,-0.0077924826,0.028222825,-0.016337683,0.036422264,0.060656253,0.11303498,0.07191684,0.00998355,0.03551483,-0.05147475,0.045798287,0.08837614,-0.054013576,-0.017429166,-0.06786162,-0.03580462,0.006409093,-0.0056435005,-0.049595468,0.01734031,0.030585883,-0.067450106,0.009675463,0.010192995,-0.06035629,0.030959688,0.057190794,0.112783834,-0.048587233,-0.030759215,-0.034059756,0.06641987,-0.03636229,0.020711774,-0.029383516,-0.022528628,-0.00042113502,-0.01631616,-0.009256553,-0.079899475,-0.012937037,0.08439681,-0.056252334,0.0060720905,-0.05035797,0.0111929225,-0.0029113574,0.059405398,-0.056937728,0.035713732,0.04394222,0.013277757,0.08278281,-0.05199135,0.010328911,-0.007854315,0.022384673,0.0354662,-3.693539e-08,0.08786364,-0.08192737,0.06843632,-0.07328594,0.015612021,-0.048804067,-0.028450284,-0.03300591,0.039102804,-0.03860005,0.04851424,-0.003470083,0.03507423,-0.017210055,-0.0013234122,-0.0043326463,-0.091293044,0.025443064,0.016532779,0.009370154,-0.07761862,-0.018290343,-0.045494877,0.00728294,0.034187153,-0.049812496,0.037145715,0.0840054,-0.045469336,-0.00657279,-0.02587326,-0.014204713,-0.05110729,-0.056390155,0.0016023495,0.053986162,-0.037330087,-0.0051529543,-0.03135,0.0034366373,0.06860581,-0.039022993,-0.062507465,-0.025496816,0.031550687,0.054674797,0.023719,-0.011570168,-0.07567333,-0.038392834,0.020539718,-0.029317511,-0.027419804,-0.014333765,-0.11284951,0.07810861,-0.028644213,-0.07854294,0.0051296726,-0.08335367,0.062008604,-0.015803352,0.14456682,0.06748865 +3.4.24.14,Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family),384,1.0,-0.09713245,-0.06946511,0.0037150995,0.005766279,-0.0053245905,-0.021100707,-0.021969331,0.06352937,0.017221235,-0.028608976,0.049096525,0.11079911,-0.038376056,0.108885475,-0.0694639,-0.06290481,-0.008960455,-0.015198918,0.028869256,-0.035726115,0.027326766,0.027800389,-0.0013411571,0.020556772,0.0054189847,-0.0712111,-0.055469975,0.0009846681,0.03650927,-0.03750704,0.011263642,0.0023475874,0.036588203,-0.00045959465,0.10663533,-0.066318475,-0.05198305,-0.011240083,0.0964465,0.041765504,0.09773025,-0.09059094,0.011296292,-0.07925207,0.13764028,-0.025185678,-0.026804432,0.03403085,0.04573681,0.07627789,-0.07394509,-0.018750656,-0.031275854,0.08299915,0.0059931194,0.003159812,-0.11069987,-0.061163027,-0.008344793,0.035669956,-0.0039564352,0.020682214,-0.015837433,-0.016602905,-0.036757987,0.01099862,0.03717309,-0.0012450715,0.034247737,0.11780249,-0.009774495,-0.018675392,0.01745967,0.07276594,0.10085048,0.017837638,-0.05319362,0.0054701166,-0.089908056,-0.022104258,-0.0002060147,-0.013802099,0.08796105,0.08516987,-0.047170762,-0.010206672,0.026735816,-0.04746273,-0.038682245,0.02433782,0.0056398343,-0.04399715,0.040301308,0.008639986,-0.017424634,-0.008465578,0.0134070795,0.036112577,0.025242608,0.031879812,-0.005149917,-0.036997136,-0.028449204,-0.0451536,-0.095698826,-0.0007845979,-0.06526591,0.023877319,0.07349926,0.0097143,-0.0012131108,-0.025653163,-0.020763157,-0.038819507,-0.08566132,0.09982409,0.07904528,-0.0027124002,0.007485862,-0.017847527,0.019740164,-0.025732012,0.07135114,-0.0043045017,-0.114356175,0.03190956,-0.038203444,2.270469e-33,-0.055919066,0.0049700965,-0.0010213738,0.001095128,-0.006212431,-0.027920287,-0.054758146,-0.12723142,-0.004161347,-0.0576548,-0.035896074,0.033234153,-0.009157255,0.0067324094,-0.0046954807,0.023871321,-0.007172916,0.0150618935,0.006764277,-0.034965474,0.14899963,0.11480368,0.0049790195,-0.025024032,0.06693719,0.0070219594,-0.017114135,0.029850706,0.04826704,0.01330134,0.04286272,-0.039777458,-0.03385918,-0.02978339,0.0041316026,-0.0018960948,-0.059737794,-0.11853264,0.010125194,0.040452674,0.016589858,0.011976373,-0.021004075,-0.0048205303,0.05334175,-0.069214694,-0.011417013,0.09414137,-0.020772109,-0.019297032,0.08698912,0.023513287,0.07494661,-0.067875266,-0.01007811,-0.026821267,-0.01618699,0.010408159,0.009241151,0.021469472,0.08261366,-0.06413478,-0.033508196,0.020676164,-0.06492776,0.047479905,-0.08003881,0.0803789,-0.016476603,0.004671826,-0.056933135,0.031132238,0.029035855,0.039851397,0.06771317,-0.020244239,-0.02357124,0.11161047,-0.05958729,-0.00081554794,-0.05616685,0.035733778,-0.03149289,0.034947235,0.011643269,-0.029950315,0.055847045,-0.041100267,0.07832573,-0.019569792,0.05458573,-0.049927503,-0.05356079,0.0794228,-0.0072288606,-3.121469e-33,-0.0031895242,-0.050680924,0.048588004,-0.0417957,-0.10159028,0.014844416,0.0971262,0.037317645,0.08079379,-0.0076700477,0.06545789,-0.019685242,-0.077913776,-0.10545871,-0.0036787945,0.03273405,-0.015461717,-0.0677449,-0.08493359,-0.0051513496,0.0052593215,0.027449606,0.1350086,0.048083,-0.01349018,0.032210227,-0.055401605,0.028440109,-0.037311234,0.07118211,-0.029611735,-0.01655031,-8.764415e-05,-0.060932253,-0.0942905,0.018185154,-0.03099615,-0.011928127,-0.049424734,-0.08257695,0.023012558,-0.009052422,-0.028987512,0.074211635,-0.013952947,0.073836945,-0.026767148,0.033870254,0.006405654,-0.029007996,-0.019998595,0.0076054307,0.062340476,-0.04319306,0.053468373,-0.032945603,0.07540488,-0.0077690505,-0.052559122,0.0767558,0.009007944,0.0048883753,0.010146418,0.002110525,0.12981765,-0.029096665,-0.08169901,0.046446383,0.010617622,0.021993447,0.02461086,0.015953701,0.041845538,-0.028180685,0.036724016,0.03215124,-0.037108194,-0.004143279,-0.093424626,-0.031808607,-0.072989985,-0.061990388,-0.03167301,-0.007652564,-0.02354996,0.015984898,0.048729785,0.04751538,0.026105471,0.021910256,0.04646038,-0.025233166,0.08486902,0.019206451,-0.058505543,-2.8975935e-08,0.031807758,-0.042208042,-0.006343468,-0.072319016,-0.061457764,-0.03669535,-0.11575827,0.054923005,0.029470436,-0.024180109,-0.065650985,0.064283065,0.044967335,-0.033494588,0.0684816,0.008643949,0.04967742,0.024140721,-0.02587653,-0.13808608,-0.08367133,-0.05510742,-0.03599322,0.123961225,0.027096283,-0.011579736,0.015858676,0.0019059221,-0.128724,0.021050926,0.024720995,-0.04010872,-0.0042597996,0.019827563,0.0073640146,0.064784124,0.0057050823,-0.040595528,-0.022370938,0.021714073,0.052304823,0.012660356,-0.012355676,-0.0046994686,0.0012946421,-0.027190816,0.016108457,0.037166674,-0.008573088,0.03865852,-0.0017147788,-0.023418264,-0.07083783,-0.04090139,-0.089929156,-0.024923317,0.032228302,-0.033204645,0.025939208,-0.05816184,0.03721877,-0.031892877,0.17689954,0.03674865 +3.4.24.15,Thiol compounds activate at low concentrations. Type example of peptidase family M3. ,384,0.99999994,0.023943352,-0.06698767,-0.06893132,-0.056020476,0.052382596,0.022077389,0.024902957,0.1640433,0.070512004,0.042038668,0.056914102,-0.074942686,0.0074184956,0.032990243,0.058036536,0.00023894815,0.014565142,-0.02446532,-0.039131362,-0.07232143,0.006348408,0.06935714,-0.030424569,0.055899963,-0.115931846,0.027909903,0.0034723636,0.0053230287,0.032801703,-0.044168,-0.03470255,0.0025725174,0.12103385,-0.03135538,0.030990068,0.054035574,-0.10245386,0.024092186,0.025837364,-0.020709045,0.06585508,-0.048481327,-0.023670226,-0.027300587,-0.030613806,-0.040692203,0.0046893293,0.120429315,0.017606338,-0.025852423,-0.013999498,-0.04895351,-0.0048327814,0.10045545,-0.07600738,-0.0383562,-0.09954355,0.037959833,0.021797443,-0.02047416,-0.0216894,0.040518038,-0.019563794,-0.05226168,-0.026240071,-0.013619746,-0.004322352,0.009866781,0.057582665,0.014687643,0.039356004,-0.03276179,-0.01297698,0.060024798,0.015542065,0.02240756,-0.014575891,-0.06394688,-0.05352858,-0.020353487,-0.040797587,0.02199263,0.036427125,0.05516704,0.03625923,-0.03175977,0.008817965,0.013392233,-0.018176254,-0.035179462,0.11521475,-0.017626373,0.056552686,-0.0017538322,-0.07190892,-0.01353523,0.091347046,-0.049980957,0.0434618,0.004974822,0.048390735,-0.01080203,-0.123253636,0.0034803615,-0.049147047,0.093252845,0.025358466,-0.015538039,0.0027888995,0.0063487454,-0.018754652,-0.046634547,0.008835698,-0.0688585,-0.07054244,-0.0083808685,0.0090213455,-0.04151938,-0.026339924,-0.04827078,-0.0024985464,-0.016764734,0.00452251,-0.0050338646,-0.06410638,0.044148188,-0.047904506,3.6168602e-34,0.04166701,-0.0327699,0.016548961,-0.0027364169,0.0330993,0.017214427,-0.058676295,0.017101504,0.08776122,-0.025844598,-0.048440523,-0.03396356,-0.0578769,-0.03600726,-0.04602217,-0.047911756,-0.071040645,0.049184646,0.07321017,0.01912874,-0.041677058,0.040561818,-0.045126256,-0.003783432,0.03538104,0.049170334,0.0620997,0.026895814,0.012123868,0.028742896,-0.01719342,-0.017021203,-0.053790554,-0.07906803,-0.04733652,0.045987792,-0.043022517,0.039746806,0.0018522626,0.0016373196,0.00056256924,0.047700617,0.0023666923,-0.05633031,0.054048046,-0.060721252,-0.0687833,0.011503884,-0.012300469,0.0075511388,0.029397864,-0.116677366,0.016181512,-0.00590953,-0.019299062,0.028199216,0.020402864,0.02405611,0.048457272,0.0740876,0.069886655,0.05008391,-0.03764706,0.05345217,-0.03488442,0.024846796,-0.10980111,-0.03308717,-0.024957499,0.11547462,0.003198312,0.0796994,0.06150161,-0.027034752,0.04598656,-0.032870866,-0.031954013,0.06620993,-0.02853862,0.012235721,0.054082826,-0.060736556,0.017101087,0.072884396,-0.07321475,-0.021859024,0.020852402,0.033658486,-0.0914826,0.007815708,0.010226934,-0.054945663,-0.0129369935,0.03939135,-0.010237591,-1.2065586e-33,0.07093506,-0.015125838,0.06848702,-0.043141194,0.011766828,0.09321649,0.0056854137,0.0036750846,0.03983992,0.015030184,0.057006948,-0.004394019,-0.061930835,-0.046153836,-0.034789953,-0.020282678,0.047814347,0.04075115,-0.050961524,-0.0086279195,-0.09978139,-0.06606791,-0.033983413,-0.0036313238,0.0016296658,-0.01925676,-0.05989575,0.0765209,0.043916687,0.044013422,-0.03692777,0.06962997,-0.046672896,-0.03879152,-0.042217553,0.026770351,-0.01350613,0.00783659,-0.04366103,-0.028931832,-0.0008222632,0.045891166,0.10903555,0.079233445,-0.022531006,0.08982403,-0.0024567668,-0.054237437,0.012183078,-0.049325727,0.03798834,-0.077524826,-0.026884144,0.107155524,0.04800334,0.0060965926,0.0057818713,-0.007556714,-0.0054524117,-0.04710174,0.0014809293,-0.046949904,-0.08686938,-0.0467176,-0.021004686,-0.030545674,-0.15623926,0.016363015,0.13831002,0.01856858,0.09872381,0.0005780428,0.087203756,-0.10332752,-0.054778546,0.032533057,-0.054674797,-0.103030205,0.008469716,-0.04325067,0.00011029092,0.0011786352,-0.05064425,-0.03870646,-0.048235383,-0.0042569106,-0.045464557,0.046375208,-0.007977865,0.12613688,-0.019072678,0.02068183,0.049073007,0.10008694,0.02649284,-2.3002446e-08,0.03071448,-0.0636338,0.021171648,0.0040672794,-0.06420537,0.017387338,-0.012911263,0.0301872,0.049374063,-0.012038684,-0.04022048,0.053370763,0.024761055,0.013377927,0.058897685,0.082133874,-0.014580902,-0.0050983927,0.005687361,0.0075495294,-0.07887756,0.026812524,0.013912513,0.01899102,0.007565718,-0.015894677,0.06992637,-0.028575772,0.00012480185,-0.038541082,0.040849317,0.04992253,-0.046576954,-0.0071325745,0.057507794,0.06435688,-0.034584682,0.0004420901,-0.058349077,-0.052375093,0.0075961114,-0.0770109,-0.1686947,-0.015765674,0.011670292,-0.045666955,0.002158226,0.10645403,-0.046423614,-0.03679601,-0.036116786,0.024553992,-0.008190199,-0.026661493,-0.07729798,0.04587297,0.016852608,-0.03365002,-0.008658439,-0.11931395,0.11178095,0.040878795,0.15739885,0.05952603 +3.4.24.16,"No absolute requirement for a prolyl bond: the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. In peptidase family M3 (thimet oligopeptidase family)",384,0.99999994,-0.109050825,-0.099755496,-0.13322662,-0.060901705,0.039941803,0.009572455,-0.040400334,0.11106493,0.0636031,0.0034809154,0.03276836,0.042646136,-0.0830172,0.114517264,0.035014547,0.03047355,-0.055708807,-0.0840406,-0.0454119,-0.011121722,0.07334082,-0.007407622,0.024873966,0.007464399,-0.03803086,-0.032825787,0.06086862,0.004820127,0.032940067,-0.052439474,-0.027032336,-0.13877472,0.042733133,-0.0027485539,0.14443532,0.060743455,-0.046862867,-0.0363994,-0.036766235,-0.039420802,0.09541846,0.03457733,-0.11143693,-0.06764634,0.02440136,-0.06392201,-0.018742198,0.04785064,-0.001686307,0.07574838,-0.026156768,-0.044654164,-0.040729847,0.00034539367,-0.05482997,0.078485884,-0.011657302,0.005470841,-0.03641399,0.002418067,-0.0056176702,0.021446416,0.0294269,-0.006617432,-0.017324327,-0.009348393,0.011501498,0.035764564,-0.0068114134,0.026226625,-0.023603173,-0.054519013,-0.010202591,0.102226615,0.03697771,-0.02117124,-0.033358805,-0.0610088,-0.050172366,-0.07703576,-0.05523116,-0.022907987,0.04788528,0.04464649,0.03290801,0.0066762767,0.028334044,-0.0063470867,0.019361233,-0.031790975,0.052936092,-0.043701954,-0.033559345,0.01329114,-0.015516619,-0.015097207,-0.021689465,-0.07469606,-0.08253372,0.0063787545,0.0012801834,-0.013151897,-0.070400245,-0.046286464,-0.05231125,0.091067515,0.021396227,0.010162148,-0.0046030176,0.004361319,0.052060083,-0.03919022,0.12537505,-0.025375616,-0.0092234295,-0.036827296,-0.08903004,-0.04736555,0.10142104,-0.060530227,0.0017825554,-0.011246469,0.066418394,0.10194428,-0.03504771,0.08451259,-0.015606942,4.302622e-33,0.063643746,-0.0056634936,0.04054515,-0.017442573,-0.030548925,0.028699903,-0.05002754,0.018032432,-0.024132194,-0.07878755,-0.04837133,-0.14028728,0.06426089,-0.047090948,0.026452888,0.037977107,0.020961145,0.010947756,0.044955358,0.10609667,-0.03043844,0.059328526,0.006272445,-0.018505989,0.036807675,0.043413594,0.025143452,0.073154174,0.03718647,0.0098130535,-0.013528633,-0.11307339,-0.02029043,0.035885897,0.00943507,0.10159199,-0.020542895,-0.07299879,-0.034685493,0.05701301,0.019094441,0.015009585,-0.009324075,-0.016213417,0.043991126,-0.06599085,0.033534408,0.06927606,-0.09906611,0.031345513,0.022245094,-0.007336232,0.05981666,-0.029045023,-0.06758415,0.056505628,-0.0072813276,0.030833384,0.07985351,0.058425765,-0.022589222,-0.040573824,-0.03930887,-0.00055273453,-0.0021780806,0.121281564,-0.07542957,0.0053762575,-0.05136071,0.026812278,-0.047930498,0.076572776,0.024664892,0.047791727,0.016791446,-0.05130314,-0.013521451,0.021978565,0.053567387,0.037967972,-0.008112642,0.027003512,0.0065090703,0.054568205,-0.05640952,-0.055679295,0.01019189,-0.036626454,0.009238937,0.059408557,0.06117044,-0.05653534,-0.0076724123,0.026206708,-0.059343852,-5.7381782e-33,0.02051364,-0.05635049,0.05588049,-0.019456452,-0.03213314,0.057425957,-0.05165933,-0.05232921,0.07006925,-0.0019902436,0.09623369,-0.028782573,0.0013018672,-0.058009613,-0.020584177,0.0588986,-0.10388108,0.028533392,0.03579674,-0.015268548,0.023145378,-0.009543794,0.011039477,0.0678997,0.044073578,0.011321547,-0.059721958,0.06815618,0.0190152,-0.030675147,0.03529033,0.058649905,-0.07607383,-0.084118925,-0.08457077,0.08362386,-0.07678646,-0.012953416,-0.012188332,-0.024078459,-0.0073821847,0.039873935,0.04537684,0.016156266,-0.034222875,0.048872,-0.02492669,-0.022755943,0.024474952,-0.024897547,-0.026181173,-0.00015749446,0.04408558,0.00033643263,0.03500522,-0.011931108,-0.027211031,0.060161263,-0.026467262,-0.0032854334,0.041047286,-0.040768802,0.008763694,0.052529465,0.03805794,-0.04803547,-0.08382111,0.018469665,0.108240835,0.0067912443,0.06432283,0.001908901,-0.02528015,0.031677097,-0.0137974955,0.061144415,-0.025410667,-0.07751875,0.031200169,-0.010694092,-0.053565547,-0.01495014,-0.023906665,-0.04894452,-0.011303076,0.012546465,0.04317429,0.06673019,0.014553555,0.09698643,-0.007454102,0.011964236,0.03307773,0.070976906,0.049682464,-3.9365876e-08,0.05208308,-0.0057707164,0.029159743,-0.07691286,-0.05953295,-0.040329024,0.0664158,-0.10008057,0.014997461,0.027812239,-0.026951868,0.035653803,-0.058678217,-0.020922976,-0.010715092,0.06793101,-0.018787844,0.017362539,-0.023372136,0.0010094959,-0.052648947,0.012112497,-0.16272858,0.031360373,0.0040867045,-0.08330626,0.046707705,0.053127218,-0.056289844,0.031493723,-0.017408308,-0.010137301,-0.039461967,-0.045000337,0.049309563,0.037104692,-0.039439578,0.049420316,-0.043795113,0.020470705,0.020254673,-0.033989903,-0.029850421,-0.01851284,0.03585557,0.004850368,-0.021028645,-0.022363566,-0.0552843,-0.0052638343,-0.050908614,-0.025225235,-0.043209963,-0.10126149,-0.099794626,0.06579136,-0.0050381175,-0.0049510943,-0.064810336,-0.083863884,0.05630708,0.0056738714,0.17289776,-0.03373001 +3.4.24.17,"An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family)",384,1.0,-0.014179812,-0.080721885,-0.043983523,-0.047534622,0.08207694,-0.024763344,-0.004009153,0.08870999,-0.0030927935,0.08215076,0.0534291,-0.019675462,-0.090292916,0.123897,-0.09060174,-0.056036405,-0.078920744,-0.07351159,-0.0011649145,-0.016895803,0.054356948,0.035898726,-0.011865665,-0.027215557,-0.01113135,-0.07894151,-0.002302333,-0.07165607,-0.030829035,-0.03559919,0.002555403,-0.13776955,0.016864624,-0.011875828,0.10453895,-0.023324786,-0.016023431,0.031849213,0.019144552,-0.03525272,0.051836755,-0.028593266,-0.03387389,-0.020010844,0.051868405,-0.006316849,0.0049870154,0.0060220226,0.04318843,0.0780222,-0.039714642,-0.10215468,-0.06500225,0.038852297,0.040833544,0.09392996,-0.046635658,-0.03096995,0.033583894,0.030474847,0.02968534,-0.028386593,0.006389506,-0.04235865,0.04656617,-0.098620005,0.07214126,0.077352,-0.0872845,0.046974704,-0.007886982,0.0019983167,-0.01250531,0.07725227,0.024392096,0.06327853,-0.1069879,0.015270202,-0.050803244,0.0052534947,0.011490508,0.004566463,0.077989474,0.033399366,-0.011506218,0.0001385795,0.02932222,0.051039603,-0.045300964,-0.03510246,-0.037172105,-0.11911422,-0.020705169,-0.010885861,0.012254069,-0.0007497887,0.00869792,-0.02836427,0.044785883,-0.03615475,-0.06742168,-0.074889235,0.069030985,-0.12529397,-0.0186904,0.035983685,-0.095999986,0.059575874,0.126511,-0.010609784,0.047431342,-0.014139175,-0.008626635,-0.010260438,0.03775596,0.081118606,0.010197169,-0.03352647,0.045790102,0.00061201595,-0.00091803056,0.039196793,0.07519235,0.006165544,-0.06319408,0.036012016,-0.015392804,3.4383566e-33,-0.040722776,-0.02210991,0.0006029483,0.035480827,-0.005691583,0.028696202,-0.033660434,0.026658023,0.00563428,-0.01739495,-0.08721986,0.0002343107,0.015096499,-0.034272794,-0.00089550426,0.06973437,-0.08906967,0.0049669864,0.0071982658,-0.005987783,0.0664307,0.10740061,0.024337009,-0.076954484,0.10404661,0.045332167,-0.029025588,-0.023550885,0.080181554,-0.0074143456,0.023187488,-0.0678161,0.0017668151,0.0172008,0.08612445,0.03435884,0.06538202,-0.101475015,0.0017404222,-0.004152034,0.060204092,-0.05647303,-0.0061260234,-0.037048616,0.0626167,-0.10839726,-0.035252225,0.059306562,-0.025109846,-0.016470924,0.047875654,-0.050968178,0.051854618,-0.054956365,-0.09937455,-0.0076148254,-0.030216135,-0.0014845172,0.050811645,0.033305384,0.051125687,-0.044151053,-0.034519773,0.00022633096,-0.035125334,-0.011007732,-0.09355916,0.059189588,-0.0066388734,0.03556285,-0.033337556,-0.048947502,0.018362505,-0.04947085,0.03650667,-0.03972466,-0.043049384,0.108726025,-0.061289195,0.014708766,0.035289295,0.03212586,-0.047792617,0.010263826,0.0003105668,0.018534562,0.00884799,-0.029680355,0.02909469,0.059334975,0.04572147,0.030022237,-0.06118488,0.08401176,-0.024674932,-4.276303e-33,0.06848398,-0.058822487,-0.019442637,0.0061622257,-0.021470018,0.07716921,0.08294528,0.031365164,0.005024063,-0.037992317,0.026102059,-0.04163818,0.017492864,-0.05311228,0.01361591,0.0034219357,-0.01382253,-0.021794496,0.04697634,-0.057429623,-0.029357709,0.007307837,0.09142775,-0.019227285,0.14112337,0.044498466,-0.069618404,0.07193091,-0.05738951,0.060944308,-0.00423907,0.013269433,0.045412976,-0.03768773,-0.080259964,0.015507148,-0.044859473,-0.039727658,0.028800394,-0.012876292,-0.011937164,-0.020792704,0.0041851113,0.12980434,-0.017201416,0.015582491,-0.05430718,0.0359247,-0.0006792253,-0.041500017,-0.0070855427,-0.05739599,-0.0050589275,-0.046626527,-0.01312609,0.01366543,0.019604819,0.049367286,-0.008245416,0.0033435416,0.010477483,-0.019310439,0.026613757,0.033663046,0.1474673,0.010030339,-0.09222618,-0.029496852,-0.028221432,0.034880403,0.043457318,-0.04581043,-0.012294722,0.020185973,0.021765733,0.09588771,-0.0069191414,-0.022690648,0.020618116,-0.042951774,-0.110526934,-0.040575664,0.021175208,-0.037315182,0.024488198,-0.043763004,-0.009327325,0.12114241,-0.020718992,0.039999463,-0.023808146,0.017156782,0.026635708,0.013726791,0.025488831,-3.787966e-08,0.037063412,-0.04099192,-0.0017106753,-0.09234391,-0.008076354,-0.09319787,0.036603626,0.039379492,0.04567786,-0.021652294,-0.026911303,0.0050870026,0.039786287,0.010194503,0.024503829,0.05945123,0.050178535,0.031139433,-0.031548455,-0.03057594,-0.10351198,-0.027629202,-0.10699408,0.039603986,-0.02402008,-0.015255834,-0.0008121549,0.0592064,-0.08252259,-0.013654792,-0.010861612,-0.0057831714,-0.023793083,-0.03144277,-0.028727492,0.1613255,0.027838405,0.002291705,-0.05783977,-0.044495,0.017528515,-0.017326213,-0.007517014,-0.07600797,-0.00986284,-0.02501218,0.09217585,0.051128786,0.00839745,-0.012409323,-0.030945634,-0.05987631,-0.021911414,-0.041446026,-0.07920837,-0.016907174,0.013711862,-0.019626113,-0.0014856413,-0.009436355,0.029925618,0.041398767,0.19465733,0.017532365 +3.4.24.18,"A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts. Differences from neprilysin (EC 3.4.24.11) (astacin family). Formerly included in EC 3.4.24.11",384,1.0,-0.033027567,-0.08219004,-0.059783146,0.04181826,0.0021043334,-0.027591182,0.00669078,0.08337717,0.02396802,-0.048404895,0.0291387,-0.06214862,-0.033102155,0.064350374,-0.08459885,-0.10772014,-0.008013023,-0.017235355,-0.07081376,-0.056141213,0.10023946,0.013091064,0.008944173,-0.12653036,0.0378937,-0.050446324,-0.008347301,-0.11010564,0.022764357,-0.0553003,-0.0005680663,-0.101428926,-0.0010341523,-0.049838353,0.092162274,-0.0497971,-0.034108482,0.045294926,0.03803047,0.01301935,0.012378692,-0.038229726,-0.033646457,0.017576482,-0.067949966,-0.013071322,-0.027439749,0.010003011,0.046234354,0.076786354,-0.026032077,-0.063139774,0.0026535415,0.053933818,-0.008167675,0.031497,-0.052516263,-0.05034839,0.020457337,0.026563153,0.096366525,-0.048457436,0.03362881,-0.001922726,-0.020159984,0.04022478,0.02761759,0.008973033,0.041918017,-0.022380376,-0.0022804104,-0.03900828,0.0015076287,0.055936974,0.016125515,0.041508567,-0.014096609,0.014855446,-0.049433436,-0.05354935,0.04490267,0.07043153,0.02935963,0.03059355,0.05573545,0.047288444,-0.0027506994,0.0034194277,-0.05435314,0.037730608,-0.02088501,-0.03224107,-0.046113722,-0.032085426,-0.039956983,-0.006430114,0.051621843,0.038125113,-0.02681985,0.007975474,-0.009769001,0.09097658,-0.02253643,-0.040614724,0.0667637,0.01992398,-0.011391816,-0.02943937,0.06769579,-0.023115063,-0.03530576,-0.036958214,-0.004444047,0.01776179,0.064248934,-0.022219421,0.04870343,-0.020810973,-0.034698397,0.04925551,0.021275483,0.01023629,-0.047035996,0.008366056,0.09097382,0.0494305,-0.103415176,-1.0482761e-33,0.008606504,0.041587226,0.04481592,0.033144698,0.03444549,-0.012872718,-0.005351134,-0.0014266404,-0.018543074,0.024708254,-0.05928559,-0.15776189,-0.040824115,0.006102553,0.007021724,0.04009328,-0.09701566,-0.05597463,0.068313845,-0.014427361,-0.007768638,0.06461359,-0.039823335,-0.017819265,0.033278875,-0.044511545,-0.12534551,0.052003697,0.077828474,-0.010004482,-0.01749633,-0.051047955,-0.037128143,0.035830382,0.02228674,-0.0746893,0.022930494,-0.12143519,0.009126974,-0.015438527,-0.044126116,0.013198382,-0.007771841,-0.032824837,0.05596358,-0.11148979,-0.12963882,0.038015816,0.07573448,0.010433687,0.07517406,0.021971509,0.118218906,-0.03276043,-0.03431882,-0.06431507,-0.060812175,0.039412152,-0.022650305,0.099350035,0.04110905,-0.00042023323,-0.03928907,-0.037913587,0.08799035,0.09066573,-0.108115256,0.019155245,-0.025046876,-0.029743832,-0.115506,-0.026218208,0.018841729,0.0045147394,0.034511805,0.009001792,-0.030605989,0.109553576,0.04586078,-0.018611955,-0.020697044,0.0665115,0.031742405,-0.008123161,-0.030310573,-0.0013534098,0.05723276,-0.046880536,0.074428596,-0.023263145,0.07984912,0.053335782,-0.15311325,-0.0054302835,0.0031156768,-4.0521425e-34,0.08256252,0.05888158,0.029101284,-0.00981819,-0.053627495,0.091964625,-0.040919367,0.03216942,0.0041934857,-0.035129312,0.07789456,0.086174704,0.062835716,-0.08466896,0.074199244,0.0033322126,0.038809385,0.04792905,0.032378722,-0.05752605,-0.04365482,0.020624828,0.016400818,-0.033648424,0.04136403,0.030678907,-0.024560144,-0.0044010794,-0.036267426,0.07840231,0.0790882,0.05957507,-0.053882066,-0.14421476,-0.015465026,-0.1024246,-0.06894308,-0.05791445,-0.03226706,-0.06954994,-0.007056873,-0.008197183,0.07259654,0.038477767,0.01729216,0.049921133,-0.03771592,-0.0056845476,-0.040983055,-0.04270899,-0.0044681868,-0.011757771,-0.011225819,0.029967722,0.040864524,0.07836375,0.068259686,0.012664185,0.079113804,0.01145742,-0.0349547,0.07640285,-0.011712131,-0.018090786,0.03110493,0.009534819,-0.002391605,0.10606758,0.017319687,0.034313183,0.050360262,0.037854478,0.009878111,-0.033274848,-0.031246992,-0.00063124264,0.03669847,0.005129423,-0.031375654,0.01784166,-0.08626913,0.09036138,-0.039956372,-0.04403223,0.0064664227,-0.016008351,9.405929e-05,0.10049384,0.023544172,-0.019831277,-0.032758344,-0.044356454,-0.08076667,0.026915668,0.09195386,-3.4350077e-08,0.07505411,0.059154972,-0.000869208,-0.09462043,0.001286648,-0.04377891,0.00022906595,0.040094074,-0.024916017,0.08101219,0.058034286,0.055776305,0.008629588,-0.06237444,-0.030647302,0.045261797,-0.004878188,0.03397694,0.021335145,0.0089579625,-0.05686617,-0.034716345,-0.110685766,0.022060432,0.05349453,-0.08741422,0.08427888,0.08145308,-0.05103268,0.019803101,0.0022865902,0.0016336581,0.016151179,-0.025685547,0.020145541,-0.034415875,-0.028861402,-0.02049879,-0.0011703218,-0.0061166612,0.008949948,-0.026706183,0.028903823,-0.001738058,-0.036872167,0.03422628,0.0133440485,0.052114327,-0.00588004,-0.023106957,-0.05552611,-0.00025217814,-0.032619543,-0.009226004,-0.060200308,-0.012636579,-0.015964521,-0.04382586,-0.009642559,0.0028520536,-0.053402264,0.029599175,0.1638501,0.039181408 +3.4.24.19,A 100 kDa endopeptidase the activity of which is increased by Ca2+ and by an enhancer glycoprotein. In peptidase family M12 (astacin family),384,1.0,0.0020066965,-0.04963817,-0.108542554,0.012067445,-0.014753924,0.048686303,0.026031988,0.102509044,0.018223053,0.06372611,0.11841175,-0.008236527,-0.01246042,0.054733157,-0.031831626,-0.008390361,0.004485637,-0.002456458,-0.082904294,-0.12163698,0.07762913,0.043812547,0.05119007,0.017082272,-0.013881736,-0.021456456,-0.064593524,-0.09447101,0.05276449,-0.050808962,0.014478737,-0.04892796,0.10390452,-0.033928655,0.03373266,-0.0048151193,-0.039196238,-0.018169444,0.005206494,-0.046854623,0.028663905,0.021539345,-0.033261944,0.0059527294,0.008263224,-0.009817238,0.02431284,0.022259224,0.059601873,0.06021863,-0.006717699,-0.046562128,-0.077187486,-0.0011098285,0.02812748,0.072271965,-0.121125,0.011079864,0.0514404,0.02710228,0.048845217,-0.02737843,0.014575441,-0.03228253,0.00091794896,-0.106501326,0.0059922594,-0.023991082,0.00400459,0.056054782,-0.008052912,-0.060402546,-0.021043712,0.0389172,0.038651563,0.025243314,-0.10166564,-0.014905133,-0.06635473,-0.055958096,0.071042106,-0.024202663,0.0659699,0.0712436,0.04783486,0.0049709403,0.05933671,0.05324422,-0.015530855,0.031510625,0.059991337,-0.081854776,-0.0061163763,-0.020940738,-0.016889999,-0.033294693,0.032453414,-0.12466337,-0.032200493,-0.019293137,0.013652006,0.0037663365,-0.04510747,-0.06781442,-0.03886417,0.05582628,-0.07918087,-0.0070105814,0.077819385,0.026790582,0.04123446,-0.022326201,-0.02969726,-0.0752566,0.026156625,0.09229609,0.04501647,-0.009250244,-0.0018296856,-0.04311584,0.08782985,-0.037159003,-0.0094306115,0.036777068,-0.023919426,0.06057834,-0.06748123,1.026451e-33,-0.0030946124,0.054564912,0.038652614,0.022327926,0.026306912,-0.019427227,-0.0016898204,-0.010406108,-0.002768849,-0.05931163,-0.08946251,-0.04735375,-0.01905238,0.10292889,-0.033861697,0.041035715,-0.08415929,0.011373838,0.032796044,0.014717524,0.03370184,0.051055774,0.0033742595,-0.029233923,0.108115345,0.026579034,-0.010116903,0.035948113,0.038935974,0.0069533894,0.03328503,-0.042303268,-0.08038255,0.00061322993,0.011833431,0.020353377,0.09954592,-0.1251468,0.05856465,0.07586994,-0.036815282,-0.024529582,-0.02221263,-0.017733743,0.044346105,-0.06421566,-0.002686399,0.035878237,0.023606911,0.058193743,-0.027782556,-0.038864482,0.06523192,-0.009791059,-0.06817112,0.049277026,-0.030291392,0.020589983,0.023099147,0.055840835,0.03372128,-0.01531065,-0.05575436,0.03662167,-0.034599464,0.024355346,-0.051098913,-0.004062767,0.0019574417,0.05607516,-0.0745637,-0.018268617,0.08891685,0.03312068,0.044595473,-0.048603263,-0.07117421,0.08236251,0.010799949,0.041956853,0.011785481,0.052091114,-0.011942757,0.009592471,-0.006131038,-0.00013259758,-0.014421757,-0.07294038,-0.047188465,0.031665016,-0.033558372,-0.0050892895,0.028280698,0.078449935,-0.08335337,-2.5726497e-33,0.08749179,-0.08369503,0.019464549,0.011302573,-0.01930311,0.052607827,0.025207384,-0.0074716583,0.03738868,-0.07596964,0.08013862,0.009587891,0.036239956,-0.026241489,0.0142060565,-0.022435522,-0.018505294,0.14129433,-0.029731708,-0.051643904,-0.009114917,-0.020885482,0.060382776,0.007778306,0.09559846,0.014868227,-0.040194813,0.04926877,0.0050814277,0.04054545,-0.027712498,-0.032773923,-0.052632898,-0.034781896,-0.07917392,0.037297327,-0.091967635,-0.027040597,-0.037542343,0.01634232,0.0063867955,0.051692702,0.05423972,0.07402576,0.045052562,-0.02561086,-0.038922157,0.06430624,0.021067807,-0.10193252,0.039146174,-0.06461253,-0.012631972,0.04936252,0.033884525,-0.005483714,0.06686829,0.037182137,-0.020248089,0.02028819,-0.03483047,-0.01882764,-0.008810029,-0.0041819955,0.081894726,0.0067232777,-0.08554842,-0.016866984,0.08739249,0.032368828,0.019314596,-0.09168632,-0.003759763,-0.0070774667,-0.058518082,0.012252239,-0.09701503,-0.07345328,0.04072985,-0.014047362,-0.0997059,-0.02201591,-0.014814927,-0.016302295,0.011163488,-0.011358691,-0.047755577,0.1018929,0.05095435,0.08351028,-0.08023795,-0.01862688,-0.016523426,0.03568633,0.011309073,-3.3040813e-08,0.07210451,-0.025936365,-0.0034795958,-0.10970578,0.018293286,-0.019282795,-0.036979437,0.042415634,0.0026970112,-0.083918296,0.052146595,0.012966295,0.02978509,0.021706745,-0.007937789,0.10333861,0.019532302,0.074211575,0.011589192,-0.0387476,-0.12698303,-0.003941241,-0.067354865,-0.015401168,-0.0050195092,-0.03731096,0.015620199,0.15100423,-0.023082761,-0.042772282,0.046873998,-0.07411406,-0.069911845,-0.0137978755,-0.00044476226,0.04893973,-0.013989948,-0.01606709,0.014053756,0.010616966,0.0035877377,-0.020063542,-0.01963197,0.03657947,-0.026290417,-0.013538587,0.070318975,-0.056696367,-0.10151025,-0.026860876,0.02901613,-0.01910423,-0.04670561,-0.08073051,-0.16409232,0.045218244,-0.019058006,-0.023473693,-0.015138528,-0.092376515,-0.03012822,0.04471282,0.1446892,0.022901895 +3.4.24.20,From the honey fungus Armillaria mellea. In peptidase family M35 (deuterolysin family).,384,1.0,0.008095784,0.03371475,-0.042107765,-0.024278272,0.069832794,-0.0047781705,-0.036569357,0.0038576082,0.017347993,0.055239126,0.13546881,-0.06852901,-0.006144021,0.026843768,-0.083205014,0.0347468,-0.019810027,-0.019459318,-0.034325544,-0.03350432,0.036630075,0.026508102,-0.0011556378,-0.020137873,-0.0055227517,-0.0151745835,-0.006360046,0.020406507,-0.04916727,-0.114105396,-0.020180406,-0.03899814,0.06866031,-0.051743176,-0.00516402,0.013668135,-0.0066540022,0.0077012037,0.13910788,0.054075196,-0.043981228,-0.045063656,0.013921225,-0.046889137,-0.072851956,0.04140574,-0.06589009,0.11911908,0.123786114,-0.01742882,-0.05969056,-0.051916912,0.027250657,0.008049711,0.027464313,-0.038243055,-0.019712655,-0.045869034,-0.019806866,0.041090064,0.046529718,0.013704416,-0.040551525,-0.03497574,-0.11415319,-0.024318954,0.05440442,-0.0382567,0.04866704,-0.02137963,0.01440075,-0.040487092,-0.0039154785,0.055703986,0.043750785,0.09785632,0.021477757,-0.05181777,-0.0394738,-0.019193694,-0.06068819,0.046193857,0.0458819,-0.003866555,-0.026278153,-0.025654677,0.04739849,-0.019983243,-0.0145458765,0.004273642,0.006037129,-0.029123059,-0.0024572012,0.008127775,-0.030607507,0.12834436,0.017826222,0.009040047,0.044099893,0.0045941784,-0.030485593,-0.044191517,0.015073164,-0.006710099,-0.07575812,-0.01613736,-0.016374439,0.038466666,0.07878104,-0.055087037,0.02323992,-0.030051725,0.015136037,0.0030007213,-0.046769544,-0.041827068,0.03592482,-0.0034720101,0.005272317,0.021075206,0.044671405,0.06410585,-0.051664956,-0.0016410127,-0.023818096,0.06475267,-0.069306076,1.2224598e-33,0.05613382,0.011978959,0.008671882,0.05779774,0.04165021,-0.0023848412,-0.057399735,0.051411066,0.011277081,-0.08898721,-0.09798916,-0.064153306,-0.033160854,-0.02942556,-0.05829186,0.052149296,-0.018401233,-0.042547163,0.04037192,0.08805504,-0.06645691,0.068009816,-0.0528954,-0.076554604,0.0061116265,0.13818741,0.04585754,-0.005991631,0.09603087,0.011910624,0.017484086,-0.07447966,-0.05896947,0.009790183,0.03261711,-0.0009500858,0.01893097,-0.06687167,-0.05212823,0.010617514,0.051458616,0.046134427,0.054634683,0.013504215,-0.005274379,-0.022256019,-0.0756495,0.018608188,0.052525606,0.03065317,0.026833981,0.04700294,0.095561735,0.018126152,-0.0159468,-0.011056705,-0.036211908,0.024199886,-0.0019418579,0.11555633,0.025910897,0.11903031,0.041610487,0.04431738,0.06601313,-0.02848896,-0.0688143,0.020155849,-0.0077463184,-0.023176137,-0.017637948,-0.009079791,0.013382495,0.05715725,-0.01691582,-0.0024120365,0.04633596,-0.0038116758,0.028944544,-0.02415973,-0.042101644,0.03945683,0.032139283,0.046294592,-0.07120055,0.014797078,-0.064701244,-0.034128122,-0.030739397,0.0021043033,-0.08545057,-0.01741338,-0.04852846,0.0109255295,-0.07224704,-2.9760308e-33,0.08715447,-0.09803903,0.076958865,-0.052981604,-0.0632511,0.10206552,-0.037757583,0.073692836,-0.010048912,0.031406727,0.031165577,-0.08225615,0.062081005,-0.0016860446,0.0040056105,0.07543737,0.05467555,0.04173908,-0.07266224,0.03497247,-0.07054248,0.12733649,0.038712107,-0.0022200258,0.08608123,-0.034703493,0.069475524,0.05459789,-0.07094655,-0.0057684584,0.025671268,-0.02489631,-0.04407623,-0.09244054,-0.0139363585,0.013679325,-0.04314754,-0.091873646,0.057058364,0.012647661,0.0028939722,-0.02077411,-0.0038057996,0.028603869,0.051034275,0.09598027,-0.078231744,0.051406465,0.023554593,-0.011623773,-0.018819036,-0.08198473,0.04183756,-0.0035377773,-0.0016949924,-0.07723702,0.095440224,0.08498141,0.06463216,0.054514285,0.040187057,0.02756339,-0.041095912,0.0755681,0.0062696724,0.08888471,-0.09382344,-0.035319988,0.012108035,-0.023915263,0.070217796,-0.049558323,-0.023936221,0.05297101,-0.06414846,0.074746184,-0.017480005,-0.045178067,-0.04267248,-0.009959988,-0.022243127,-0.06880001,0.016506251,0.011881564,-0.008345315,-0.065840565,0.05334726,0.019325577,-0.053084742,0.04238715,-0.05598858,0.039417513,-0.06212035,0.057510126,0.062149186,-2.2314104e-08,0.1256142,-0.05597301,0.03668888,-0.1165804,-0.02113518,0.019631773,0.022300577,0.0014572671,0.008200445,0.027091587,-0.058939,0.012478085,-0.0011605422,0.05313126,0.030414902,-0.0007808083,0.057455562,0.04176107,0.0072817155,-0.01020027,-0.052107688,-0.012604107,-0.012871223,-0.019669443,-0.022041114,-0.10126101,0.080897406,-0.0023704823,-0.011099716,-0.08836031,0.02741038,0.04265032,-0.048975684,-0.08761035,-0.025566174,0.054852057,-0.055595938,-0.058298245,-0.019700682,0.01429825,0.0031098323,0.008592966,-0.080123655,-0.073976755,-0.039593536,-0.09038998,-0.036348857,0.10307206,-0.022581723,-0.006586833,-0.0008926959,0.024480991,0.007367551,-0.007906699,-0.11034981,-0.07500092,0.043730777,-0.09880053,0.032726992,-0.022802297,0.014769032,-0.0038904755,0.11366552,0.013613268 +3.4.24.21,A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12.,384,1.0,0.07464765,-0.036450684,-0.13719766,-0.039781522,-0.0040965565,0.032452133,0.011850687,0.026891332,-0.0037873015,0.013674132,0.06383127,-0.093776986,-0.083956055,0.046894815,-0.118515424,0.0011487898,0.0076205204,-0.073658474,-0.032794263,-0.021620508,0.07900753,0.07312813,0.022301177,0.022876263,-0.067633554,-0.013888489,-0.023368064,-0.08882204,0.0044473754,-0.061505534,0.033535123,-0.06454029,0.08853507,-0.043957554,0.092894636,-0.017235989,-0.024710083,-0.012289246,0.082829,0.023383824,-0.0036094764,0.0713135,-0.009164761,-0.008202118,0.0008673541,-0.018493436,-0.0016744424,0.058138285,0.061716292,0.03338882,-0.05616538,-0.068880506,-0.10499169,-9.5866315e-05,0.069385946,0.04608259,-0.08336613,-0.06662703,0.00864632,0.06475473,0.054423943,0.011565687,-0.0033460734,-0.03624601,-0.011813774,-0.061130628,-0.011451163,-0.047216102,0.03819798,-0.023378529,-0.026325138,-0.059667513,-0.012717223,0.02414734,0.0134974215,0.0894045,-0.052979384,-0.047382884,-0.0695172,-0.041541275,-0.04021663,-0.014002099,0.10733803,0.07004326,0.05290292,0.0015588612,0.015138584,0.075296275,0.042801756,0.015423171,0.035929434,-0.100612015,0.055656936,-0.03568942,0.003645456,-0.038485806,0.0063825757,-0.09562402,0.010313222,-0.0025905028,0.014291311,-0.040498383,0.028007569,-0.09642324,-0.047855943,0.04424394,-0.07623305,0.020437881,0.11418107,-0.055263832,-0.037610866,-0.014923194,-0.007754777,-0.07828685,0.038366567,0.033704903,-0.037151948,-0.0637218,0.007304362,0.041699387,0.076670274,0.0053644977,0.017806038,0.045003083,-0.016958605,0.111808784,-0.11754366,2.488465e-33,-0.0078861,0.04191662,0.079983056,-0.013561993,0.018883312,-0.039645765,-0.018989034,0.010513629,0.026601842,-0.012861307,-0.08935453,-0.035941284,-0.017101703,-0.010771058,-0.035537634,0.05781914,-0.08195387,-0.0046386616,-0.032992,0.05731601,0.02443182,0.07388054,-0.00041748094,-0.09980651,0.05646105,0.0074985796,-0.026771639,0.013616499,0.06457279,0.032956593,0.018829206,-0.0932712,-0.09001539,0.009087158,0.014165855,-0.028504701,0.049608935,-0.10234429,-0.053699847,0.0048959763,0.0021790413,0.010316122,-0.025895197,0.0011107168,0.07640037,-0.12411661,0.031564243,0.04491518,0.0771632,0.017799055,-0.025862094,-0.028350221,0.08951375,0.004952709,-0.076394446,-0.0032838257,0.018633306,0.061213993,0.09155304,0.020750538,0.006293942,0.0026186437,-0.0471892,-0.033031363,-0.020907257,0.04019229,-0.043357983,0.009198283,0.01731903,0.03018975,-0.056375224,-0.015470036,-0.010619697,-0.013854485,0.036818147,-0.07799918,-0.027952384,0.025899833,-0.045833427,0.004188251,0.03223513,0.056278348,0.031575684,0.006962802,-0.08233842,0.010693124,0.0070414315,-0.042539183,0.0069483086,0.08493932,-0.013513763,-0.011557541,0.037441716,0.048774295,-0.0017834265,-2.0551403e-33,0.009259589,-0.055694997,-0.05452647,-0.00093485863,-0.020522283,0.034981064,0.049918283,0.06560953,0.038770482,-0.07879119,0.043769427,-0.010208448,0.059222195,-0.05599774,0.016422443,0.028625056,0.08539317,0.10675001,0.04545344,-0.08534662,-0.04556211,0.0151406955,0.04985548,-0.0306292,0.054582167,0.09383946,0.008868553,0.023066027,-0.0022233808,0.00819317,0.03734729,0.024420032,0.01295087,-0.033899274,-0.09771715,0.00498512,-0.118150905,0.0009658489,0.014418975,0.053106133,0.010310007,0.081930205,0.12161665,0.09313457,-0.015867844,0.026005369,-0.04365186,0.04874948,0.03182533,-0.112101264,-0.017984914,-0.04755295,-0.026439082,-0.038253125,0.042445302,0.021257231,0.031278234,0.06561199,-0.0064422186,-0.008610716,-0.013648663,-0.03365192,0.040558685,-0.0007319399,0.1344585,0.033109304,-0.06974446,0.001866252,0.010059459,0.08442554,0.0011579383,-0.027955651,-0.025592668,0.067250706,-0.022751156,0.026442776,-0.06528909,-0.037231803,0.0829721,-0.009503707,-0.034499995,-0.01634306,0.04271402,-0.035632376,0.027232764,-0.10985126,-0.03488207,0.057779036,-0.0077750864,0.052044198,-0.009093991,-0.042990208,0.025242444,0.038447548,0.123281315,-2.6265845e-08,0.12656106,-0.050816227,0.0004990675,-0.013561861,-0.007385288,-0.06601561,0.0062444685,0.008275749,0.03260383,-0.08385186,0.019861352,0.011399751,0.0618738,0.03772429,-0.0369253,0.07505254,0.016986806,0.011019272,0.0071828268,0.010345388,-0.06917615,0.00133106,-0.04604505,-0.044356633,-0.052055694,-0.05183606,0.050192937,0.10280366,0.027817238,-0.007897402,-0.008906151,-0.00085981074,-0.025832435,-0.025943933,-0.031695463,0.08106891,-0.06164485,0.0041693533,-0.03367686,-0.009873722,0.06186954,-0.06473912,-0.019253628,-0.03553194,-0.011668976,0.010811472,0.07074571,0.019984482,-0.048183125,-0.04272911,0.02802615,-0.027410941,0.024610752,-0.036697883,-0.09196715,-0.00077165983,-0.0007474673,-0.062349573,-0.021870026,-0.098553926,-0.0015746178,0.06529393,0.113999896,0.06273664 +3.4.24.22,"In peptidase family M10 (interstitial collagenase family). Digests gelatin types I, III, IV, V, fibronectin and proteoglycan",384,1.0,-0.00832395,-0.054506287,-0.047086485,-0.07237011,-0.011109881,-0.04897982,-0.0025540015,0.06724338,-0.008857785,-0.02247927,0.018375432,0.060735255,-0.024225265,0.071724825,-0.11966062,-0.0471297,-0.00639696,-0.004658999,0.0059178844,-0.010244158,0.030105224,0.04398258,0.025963984,0.015869753,-0.038627513,-0.076571345,0.04456434,-0.0067642117,-0.0033324508,-0.07013141,-0.037329208,-0.038212333,0.082041316,0.0021075672,0.08615427,-0.036455326,-0.017930401,0.018769683,0.08919757,-0.0071647577,0.058811657,-0.014909618,0.019999417,-0.039882537,0.055512443,-0.039173987,-0.019570528,0.041666742,0.03151496,0.07962537,-0.11761201,-0.060760364,-0.0622886,0.06444053,0.034541268,-0.033507075,-0.089716196,-0.00570961,0.05410437,0.056251418,-0.011520099,-0.03967051,0.01585702,-0.034665875,0.010754773,-0.03764937,0.08692246,0.08072347,-0.033747513,0.04379133,0.01665567,-0.013088525,-0.008062057,0.08435773,-0.009870928,0.04972901,0.0023018613,-0.009704251,-0.055488583,-4.3442124e-05,-0.013137465,-0.0054460787,0.06953534,0.03577,-0.014445117,-0.0066028996,0.063858576,0.06664085,-0.003507408,-0.024528088,0.0022017346,-0.06654051,0.01632938,0.010778602,0.007155671,-0.01429917,0.031888783,-0.027046727,0.048229385,0.003922115,0.01862873,-0.05369836,0.07840803,-0.059313145,-0.043123934,0.057000455,-0.06204797,0.064325124,0.080157675,0.036043603,0.011001196,-0.011893957,-0.03434468,-0.034920648,-0.03780354,0.037359748,0.06101025,-0.009861558,0.0652227,-0.0015080271,-0.014314904,0.035427503,0.11291905,-0.020217797,-0.11843089,0.007701077,-0.081874296,2.1035376e-33,-0.09940298,-0.019502863,0.00013496472,0.05430261,-0.060107365,-0.0106508,-0.05521023,-0.052695196,0.004580766,-0.05077374,-0.10614891,0.0315879,0.00594195,-0.02189099,-0.07759582,0.043321215,-0.05067042,-0.036494806,-0.050472606,-0.009337971,0.025880849,0.1128057,-0.0024639561,-0.07053086,0.11146264,0.007641888,0.027090775,-0.026442433,0.048111487,-0.013508789,0.032513123,-0.06939817,-0.04619037,0.0034924224,0.019961732,0.05387898,-0.010944337,-0.06745739,0.020048441,0.018239336,0.031754334,-0.037023813,0.013697995,-0.01371935,0.031559285,-0.015127174,-0.034077145,0.07837254,-0.041167464,-0.01349396,0.052415103,-0.05730523,-0.003507452,-0.03524997,-0.08100692,-0.010941435,0.0068379017,0.013427558,0.0686827,0.052084357,0.058281597,-0.047358014,0.008750202,0.020383252,-0.0878247,0.03377412,-0.17100169,0.06766335,-0.008194393,0.018586203,-0.03191822,-0.02025614,0.08727682,-0.004177312,0.049169406,-0.08411279,-0.010546599,0.058737524,-0.107594766,0.077605374,0.0005251593,-0.010834215,-0.062875874,0.057737753,-0.08149986,0.011559698,0.01752677,-0.021675456,0.09353074,0.03777761,0.040074725,0.028943181,-0.026859801,0.071668744,-0.008719313,-2.6296835e-33,0.11556474,-0.07334652,0.08361056,-0.0031363482,-0.04474907,0.014992267,0.095664054,0.0068195285,0.04458956,-0.012366942,0.029121941,-0.02677446,-0.05850917,-0.100559175,-0.003488294,0.08522116,0.0198858,-0.038442716,-0.010949999,-0.02636584,-0.0838971,0.040284954,0.060242843,-0.010238107,0.0035698996,0.050497342,0.032148547,0.032296084,0.010322815,0.022701146,-0.045263197,-0.011405171,0.00989551,0.011461333,-0.114963666,-0.0015927877,-0.017969899,-0.07672497,-0.05182563,-0.02252714,-0.029781515,0.07092783,-0.026239714,0.13027519,-0.032463036,0.060320366,0.059163842,0.018893575,-0.032617196,-0.004005677,0.03368716,-0.029537274,0.01218609,0.003661757,0.017641889,-0.016021408,0.029629955,0.06048581,-0.03412204,0.05453266,0.01890743,-0.0278133,0.0072836275,0.0047826525,0.097574994,-0.006067836,-0.13232821,-0.029949361,-0.00094534503,0.07388626,0.059630178,-0.054288592,0.029505871,-0.0064396015,0.07191882,0.1013549,-0.060249995,-0.042686887,-0.06262723,-0.09338869,-0.09534734,-0.039141804,-0.033495132,0.071875624,-0.0039654346,0.0032440524,0.019867333,0.054535333,-0.0006420589,0.0092633385,0.044599373,-0.018519474,0.04063215,0.06613304,0.03748653,-2.8918494e-08,0.046658076,-0.07278685,-0.065285265,-0.05846057,-0.02759715,-0.051077764,-0.056198355,0.030138513,0.048908144,0.038233627,-0.071136564,0.058145836,-0.022846641,-0.01579296,0.003967363,0.051892333,-0.029017242,0.023948055,-0.025592105,0.0067451624,-0.09376551,0.006178561,-0.09026189,0.07828341,-0.04011585,0.029426457,0.009008852,0.024830008,-0.066925295,-0.030455684,-0.018834842,0.046890393,-0.04631726,-0.09072898,-0.019282298,0.12651227,0.04293481,-0.0050117327,-0.0324494,-0.051571272,0.07483263,-0.092824616,-0.008922439,-0.063446924,-0.040089328,-0.02582668,-0.009313714,0.0890974,0.032400206,-0.004758485,-0.026136193,0.017419767,-0.038664307,-0.033214327,-0.03766021,0.030961156,0.0041630724,-0.048118096,0.035963386,-0.029266829,0.07488165,-0.0012927628,0.18401366,-0.01828372 +3.4.24.23,"Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll",384,1.0,-0.018389743,-0.05845441,-0.15579143,0.015853127,-0.03522985,0.026347473,-0.038899615,0.091644235,0.019710116,0.05779538,0.078971915,-0.008999261,-0.0029983085,0.07552083,-0.077183075,-0.04816905,-0.06940833,-0.058026623,0.028671522,-0.050918687,-0.035085436,0.04011831,0.041138608,-0.024851901,-0.017658193,-0.034551267,-0.016066492,0.012522588,0.003941626,-0.03497614,-0.045935087,-0.041263554,0.06982239,-0.048794944,0.114636995,-0.028316066,-0.03393291,-0.0138032725,0.122193426,-0.012099344,0.081258774,0.0047433195,-0.021776892,0.036084697,0.011008865,-0.010722308,0.06450016,0.05570352,-0.0022615076,-0.034685113,-0.065263085,-0.05227814,-0.12062085,0.09514108,0.028990354,0.023395713,-0.14796975,-0.08757734,0.012431673,-0.0024409895,0.02066864,0.051310733,0.042983536,-0.04292615,-0.06911024,0.011100789,0.054668594,-0.002270935,0.0061473097,0.0070702313,0.08215381,0.03645611,0.0300812,0.13846856,-0.028583925,0.04951063,0.0057371785,-0.032669708,-0.071376845,-0.008622089,-0.06263611,0.028791,0.054403886,0.03298027,-0.034857303,-0.022360967,0.077356294,0.0016948675,-0.03990393,-0.045028817,0.02134634,-0.03643053,-0.0060873837,-0.01941199,0.0027846696,-0.066175885,0.03224617,-0.0038250983,-0.040167503,-0.005392007,0.0032082591,-0.024547748,0.073592216,0.062306575,-0.03701892,0.10596516,-0.09463142,0.027569605,0.019201985,-0.02219008,-0.084185265,-0.0006706661,-0.086151436,-0.036871206,0.007518273,-0.009765095,0.10976184,-0.03155843,0.010220877,0.057426795,-0.012774543,2.960888e-05,0.016991379,-0.02369282,-0.032299213,0.008857912,-0.093321934,1.7997054e-33,-0.042589907,0.018880038,0.04025341,-0.016725065,-0.0241645,0.07823713,-0.040777445,-0.027957974,0.03511519,-0.08712377,-0.047589242,-0.008463761,0.028687283,-0.014941023,-0.041716307,0.08031992,-0.09513172,0.003260829,0.023396311,0.014239068,-0.051882617,0.1121138,-0.054732915,-0.0911297,0.069289595,0.019580144,-0.022502767,-0.053601388,0.041301053,0.020924473,-0.013698597,-0.03522069,-0.037323285,-0.060722414,0.014484202,0.012599849,-0.047549956,-0.0763807,0.0015185147,0.0413178,0.02738034,-0.076205686,0.038013592,0.020983437,-0.019614415,-0.0536126,-0.023100972,0.026126813,0.021271287,-0.054782063,0.01563985,-0.024184464,0.0018793598,0.020621464,-0.065293975,-0.030584872,-0.027074296,-0.036223587,-0.011033827,0.094829194,0.09279861,-0.08115786,-0.019508211,0.057261348,-0.021970233,0.0042364504,-0.1669114,0.013446884,-0.013694942,0.08544806,-0.06277998,-0.006925645,0.07960933,-0.059565566,0.04430582,-0.028062282,0.07176134,0.094778396,-0.023521068,-0.026295446,0.019145912,-0.000899105,-0.00543301,0.035589367,-0.042878762,0.02504443,0.011922882,0.04780518,-0.010880319,0.046938945,0.04549965,-0.017151266,-0.053584356,0.03963865,0.023718553,-3.0923506e-33,0.03699183,-0.03983748,0.10022796,-0.02382359,-0.057767853,0.029039115,0.10017238,0.09117187,-0.0018362477,0.023224762,0.0610503,0.0032637368,-0.01983951,-0.099287815,0.03974356,0.02902847,0.084033705,-0.023731776,0.07272948,-0.003649635,-0.10769904,0.009453782,0.027497657,-0.049467232,0.060602978,0.031797443,-0.0012666158,-0.05173393,-0.056216087,0.015475877,-0.04240212,-0.04801893,-0.04789218,-0.07607753,-0.03270655,0.014836627,-0.022122858,-0.07992759,-0.06773192,-0.07907077,0.014139748,0.020637492,0.018474685,0.14285439,-0.020042444,0.10301969,0.029095944,0.104616724,-0.011745761,0.020185458,-0.005513862,-0.03275085,-0.026633626,0.034451496,0.040826555,-0.057148814,0.028477715,0.057317972,-0.011213506,0.053024594,-0.0147129465,-0.031985696,-0.05765994,-0.0075810864,0.090665564,-0.05825302,-0.061570447,0.007461003,-0.0054370645,0.027483966,0.06505553,0.032123663,0.017510775,-0.0022665723,-0.008157177,0.08920692,-0.04192787,-0.064245164,0.00036618637,-0.009611819,-0.016066758,-0.051790092,-0.005604288,-0.0062034633,-0.0076159267,-0.032054495,0.06696443,0.08931696,0.016816488,0.02227626,0.01801008,0.012406033,-0.030787122,0.01124744,-0.024683947,-3.1541294e-08,0.0011419924,-0.0410176,-0.07535841,-0.07769653,-0.017714966,-0.049343698,0.008390715,0.029452667,0.065801725,0.05688958,0.015946852,0.024653869,0.04928775,0.008731161,0.000111057896,0.033137746,-0.023241939,0.033319097,0.050796248,0.032229852,-0.1090485,-0.02500445,-0.043400317,0.029705651,-0.03568789,-0.015117058,0.087191865,0.06484616,-0.082690164,-0.027277643,0.09290038,-0.027370166,0.015472441,-0.024422402,-0.00415036,0.026977379,0.01697767,0.005122795,-0.07920629,0.003858711,0.09540561,-0.04822363,0.026765427,-0.040166203,-0.010775117,0.015967004,-0.008687062,0.0026262987,0.022402314,-0.06320446,-0.038120266,-0.0016134967,-0.022895306,-0.011620864,-0.09588582,-0.048463453,0.026404329,-0.04874196,-0.014570633,0.029035402,-0.034629267,0.029209305,0.1541153,0.10035527 +3.4.24.24,"A secreted endopeptidase in peptidase family M10 (interstitial collagenase family), but possessing an additional fibronectin-like domain",384,1.0,-0.04500185,-0.06647716,-0.04485597,-0.04902242,0.04738705,-0.025963562,-0.040663227,0.081274234,0.039079636,0.06362162,0.055655554,-0.034344535,-0.076120645,0.09348727,-0.038786206,-0.016244091,-0.084137306,-0.06841888,-0.01517421,-0.032665707,0.050219364,0.04678659,-0.0130271735,-0.010056664,-0.05421101,-0.0128704235,0.022451684,-0.066379204,-0.016164217,-0.032701276,0.0070359227,-0.10769538,-0.01786953,0.006456647,0.081571266,0.017227639,-0.028210288,-0.0067220046,0.051046003,-0.07342438,0.044751637,-0.026726814,-0.009031378,0.017868811,0.056152094,0.019646803,0.02965156,0.06782466,0.03953852,0.09429954,-0.047314476,-0.0865721,-0.03321384,0.0018929219,0.050926514,0.10113614,-0.04486522,-0.025562728,0.045376796,0.08264141,0.020670176,-0.057730008,-0.02324081,-0.05647443,0.027859941,-0.08739194,0.06490476,0.038698528,-0.016417384,0.045536004,0.042250805,-0.00807901,-0.045475453,0.079038136,0.05765218,0.103008814,-0.11530211,-0.0022266516,-0.07227071,0.026584685,0.05264443,-0.0041893646,0.10703793,0.055820633,-0.035998486,-0.0045308894,0.047523562,0.011178887,-0.026072303,-0.021898776,-0.011849393,-0.1465426,-0.00582244,-0.021389134,0.021314288,0.0032356842,0.0027105578,-0.03858607,-0.042832334,-0.033575617,-0.032019533,-0.036578733,0.034071036,-0.08265364,-0.05027945,0.025837636,-0.0760021,0.06798214,0.11721233,-0.030764056,0.04480435,-0.01658937,0.015391357,-0.06717962,0.03693655,0.023997067,0.048937496,-0.022009853,0.04801001,0.053831674,0.0071470025,0.05204481,0.03689386,0.03741923,-0.09644647,0.01418234,-0.07419092,3.8418886e-34,-0.01889263,0.0054740184,0.025568882,0.016919138,-0.015285546,0.028984003,-0.024376983,-0.0045861118,-0.007429707,0.017378787,-0.06445997,-0.01237269,-0.010293113,-0.042202618,-0.02461343,0.05189565,-0.06869228,-0.00090941635,0.0066326885,0.009327861,0.05531353,0.13475175,0.02900597,-0.080831096,0.08980158,0.082778625,-0.030231316,0.0031308017,0.123888254,0.012054324,-0.0033436546,-0.010218115,-0.03395882,-0.043550503,0.066870175,0.02649139,0.076315984,-0.133385,0.007585425,-0.047885485,0.051399313,-0.049387854,-0.023843024,-0.020657564,0.016464042,-0.09979116,-0.025160037,0.038815655,-0.02366968,-0.0108248545,0.033252534,-0.068208635,0.050641593,-0.015043205,-0.07018962,-0.015974233,-0.03046887,0.008594655,0.062330786,0.024328878,0.09139748,-0.020159118,-0.05879783,0.0077778404,-0.09078925,-0.02144584,-0.056608684,0.06861132,-0.0024013128,0.060930274,-0.033274714,0.0037705181,0.0010362637,-0.00848174,0.062190004,-0.05596395,-0.03764512,0.09087173,-0.027423495,0.0018197867,0.06456502,0.028703302,-0.04913021,0.042762887,-0.040261768,0.0046711923,0.028384868,-0.011996153,-0.055596072,0.051406845,0.031109609,0.022784257,0.008171095,0.102642946,-0.07235187,-1.5155737e-33,0.053119365,-0.07626185,-0.014166389,-0.01701465,-0.031327143,0.025786508,0.07806597,0.02302108,0.0088079935,-0.020000279,0.055978052,-0.042569935,-0.0050735488,-0.05608923,0.001480209,0.00771844,0.050895203,-0.029000476,0.035198502,-0.046144843,-0.048543517,-0.0047550155,0.053573277,0.013643299,0.13131818,0.04325687,-0.05707641,0.07179969,-0.033157304,0.05857039,-0.02977968,0.012645532,0.050728597,-0.06851829,-0.14786683,0.010585076,-0.097559355,-0.067375794,0.07936658,-0.013731067,0.019601217,0.005538021,0.0110151,0.14029498,-0.008373254,0.038359646,-0.028827883,0.039342068,0.016303686,-0.07638876,-0.0013370999,-0.037969064,-0.003418749,-0.018658755,-0.006464641,-0.03997949,0.0248032,0.049429055,0.024691714,0.019699631,0.020066733,-0.010093218,-0.020374393,0.073887214,0.14850356,0.025384903,-0.09138517,0.0029049206,0.012598355,0.02731372,0.028523283,-0.04995744,0.055632215,0.048268095,0.044011522,0.057369612,-0.042247754,-0.038884554,0.008471792,-0.038155247,-0.096440986,-0.053382963,-0.010266929,0.0031706854,0.053686816,-0.058370866,0.038907245,0.0827973,-0.029902885,0.065089665,-0.02259934,-0.0033765254,0.05050219,0.040878203,0.009528086,-2.746738e-08,0.039318386,-0.039651703,0.012325374,-0.12009047,-0.05131451,-0.03899183,0.014682381,0.023943849,0.015605887,-0.0196112,-0.01819188,0.009488464,-0.012068573,0.046090342,-0.009249645,0.06764241,0.031358905,0.03454633,0.010805478,-0.029466063,-0.11036376,-0.0011956395,-0.09614019,-0.009109825,-0.008012665,-0.0049448237,-0.009220748,0.053945545,-0.054366186,-0.003016305,0.013943334,-0.04812747,-0.03384001,-0.010455955,-0.080950856,0.13587517,-0.033242512,-0.018352423,-0.026572317,-0.029299287,0.03094858,-0.006581284,-0.0320071,-0.041023247,-0.032614775,-0.030549506,0.13309942,0.03472421,-0.01698445,-0.020426374,0.006894741,-0.03910351,-0.043331765,-0.027472574,-0.0661806,-0.03701905,0.00092795625,-0.038342126,0.0015136271,-0.08564971,0.007919351,0.015776819,0.12685749,0.05561304 +3.4.24.25,"Thermostable enzyme from Vibrio proteolyticus (formerly Aeromonas proteolytica). Specificity related to, but distinct from, those of thermolysin and bacillolysin [1]. A zinc metallopeptidase in family M4 (thermolysin family). Formerly included in EC 3.4.24.4",384,1.0,-0.090834916,-0.015975323,-0.12143387,0.05662823,0.064180784,0.050168905,-0.008278957,0.0657308,-0.026304476,-0.023102231,0.00505078,-0.07790571,0.020737074,0.06841404,-0.10434107,-0.017510645,0.0059927283,-0.012341587,-0.034732677,-0.002869388,0.06531164,0.047763266,-0.025085626,0.018673629,-0.00097367814,0.018833138,-0.038865115,0.04392224,-0.016888553,0.08231479,-0.087811865,-0.02720649,0.043493327,-0.032486435,0.1296506,0.042145114,-0.03329301,0.019759485,0.0042045657,0.00651516,0.044271693,0.07426638,0.0035663792,-0.04598328,-0.07259888,0.084260456,0.116596684,-0.0055922684,0.038094364,0.00093191204,-0.050319232,-0.07724365,0.02835856,0.018011512,-0.0053330273,0.0027611267,-0.046866335,-0.04408379,-0.022612002,-0.01790936,0.03804004,0.0044604936,0.0021181426,0.053753383,0.010612863,-0.0066794776,0.058332764,0.03771004,-0.008112463,-0.045354325,-0.06706326,-0.014805267,0.024141317,0.094609946,0.024502577,0.10995448,0.05778754,-0.0928807,0.04513207,-0.09574593,0.022321574,-0.08505486,0.027172226,0.046567757,0.0076234494,0.011214588,0.086198434,-0.058140706,0.06520126,0.03395261,0.010769926,-0.03208073,-0.0058428883,-0.102351226,-0.06098434,0.008398919,-0.030930556,0.003851504,0.031929143,-0.035073165,-0.05017659,0.008385153,0.059923057,-0.053518496,0.008401212,0.026191166,0.01696711,0.0377099,0.10682495,-0.011077376,-0.016255273,0.008720693,0.06237922,0.03455083,0.06205988,0.013127134,-0.022663262,-0.019313911,-0.06934807,0.045516394,0.017817456,-0.012797734,0.06915488,0.017880905,-0.07920843,0.07554248,-0.060460065,3.1656504e-33,0.036204368,0.039834347,0.05236162,-0.008488535,0.07226047,-0.0094568515,-0.08906125,-0.013984358,-0.0018768528,-0.024867544,-0.07003947,-0.07871753,0.03755433,0.005231981,-0.012068649,-0.028558401,-0.01859781,-0.04108287,0.021314248,0.022157405,-0.004956738,0.104490966,0.0011329215,-0.011789065,0.011966294,0.08702601,0.0039823945,0.010832323,0.008624808,0.0057552317,-0.0074968026,-0.05531525,-0.1366572,-0.019258413,0.09606449,-0.039133877,-0.0068542296,-0.11021047,-0.0077064307,-0.004822459,-0.008162565,-0.0058642076,-0.02918127,0.013015397,0.06449832,-0.057961024,-0.11677707,0.09946282,-0.0017318224,0.0114420885,-0.0067765964,-0.0076858522,0.07289338,-0.10523974,-0.074077226,0.0042468766,0.016660914,0.06334544,0.02898657,-0.0059788115,-0.01729847,0.08315932,-0.089113906,-0.00022173386,0.038221423,-0.013384458,-0.03878764,-0.059339214,-0.040766392,0.01554796,-0.060797274,0.008886093,0.025804307,0.012151751,0.032883376,-0.06402059,-0.03231727,-0.06820163,-0.012754459,-0.057898562,-0.036440764,0.033227492,0.03645332,-0.047581047,-0.08400487,-0.09769509,0.017988827,0.007005226,-0.028186508,0.03463635,0.008025179,-0.04010159,0.04292147,0.069797955,-0.06848358,-4.01525e-33,0.018324433,-0.028389974,0.08397027,-0.030239627,-0.06380897,0.03344951,0.019200504,0.005578015,-0.03955791,-0.07904262,0.09275862,-0.07718647,0.05373998,-0.046006043,0.015266436,0.09623377,-0.054443546,0.026786458,0.037443694,-0.0697445,-0.008302754,0.034565434,0.011925327,0.003273282,0.028765343,0.010293134,-0.0034700066,0.111372605,0.0053928574,0.084659666,-0.019532995,0.066269286,-0.021585697,-0.08131301,-0.10048901,0.042624444,-0.0016412361,-0.05709702,0.08680973,-0.032614093,0.04407448,0.03479555,0.005561509,0.062798634,0.006641558,0.11702613,-0.05684712,-0.0074322103,0.05544488,-0.01073044,0.015487865,-0.050621927,-0.037642695,0.032749273,0.019345194,0.027872244,-0.025681179,0.017073715,-0.074588016,-0.023726616,-0.011776734,-0.06943657,0.10165471,0.104314394,0.040178146,0.12142948,0.028450578,0.06463751,0.06438663,-0.049026903,0.09998793,-0.0007852489,0.0054362514,-0.044946704,0.0005981088,-0.02928685,-0.039094552,-0.026889972,-0.037605893,-0.050262928,-0.031536978,0.08490057,0.004698187,-0.058624245,0.026100218,-0.08375061,0.03985766,0.089661025,0.023848554,-0.022692833,-0.02493839,-0.06599755,0.004461302,0.046013687,0.039001174,-3.7901003e-08,0.07228324,-0.03353852,0.114339136,-0.075023174,0.014802784,-0.0063499617,-0.03235439,-0.042892996,0.03277631,-0.006222766,0.01656169,0.03374903,0.0005449264,-0.002070438,0.014738285,0.040900078,-0.11622689,0.03494379,-0.027913142,0.00215464,-0.0017988058,-0.02062853,-0.0853471,0.035186965,0.013936852,-0.035681657,-0.015921956,-0.012661167,-0.038497243,-0.011035911,-0.07809926,0.019122034,-0.012966814,-0.06586905,-0.10912804,0.015681868,-0.058692746,0.031796042,-0.06618905,-0.041915424,0.03939768,-0.032422815,-0.040108036,0.040966395,0.0051254844,-0.05699581,0.0054742885,0.047666233,0.012415826,-0.039099667,0.027582906,0.0019263573,0.0008441464,-0.017607985,-0.10931371,-0.021366326,0.013842432,-0.030206814,-0.049784034,-0.030373866,-0.04159672,-0.03447166,0.16096786,-0.016799644 +3.4.24.26,"In peptidase family M4 (thermolysin family). From the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage.",384,0.99999994,-0.03100537,-0.0042526154,-0.062133342,0.015081494,0.050677683,0.07537387,-0.024398135,0.08856275,0.024096826,0.051660594,0.051461518,-0.050831888,0.06324914,0.11708989,-0.049165662,-0.022600254,-0.083155625,-0.0118316775,-0.031507496,-0.021924008,0.032752495,0.073365584,-0.024149401,0.050116166,-0.07133703,0.0102329645,0.025076479,0.061323818,0.014000079,0.041855074,-0.06158267,-0.019777494,0.058714118,-0.02908755,0.09320203,0.02454732,0.027250305,-0.0008254646,0.09238879,0.009021708,0.07301762,0.01347161,0.0524807,-0.029596286,0.03638848,0.037486944,0.045529474,0.016082766,0.14567874,-0.027906388,-0.011419824,0.005830314,0.030453859,0.086383276,-0.004905386,0.024721064,-0.06462792,-0.06607173,-0.02882186,-0.016494136,0.023325328,0.024129994,-0.0425457,0.027180692,-0.040597904,-0.032135338,0.07116268,-0.009691242,0.0048292666,0.0112445215,0.024590272,-0.037814222,0.023701452,0.108076416,0.00018095749,0.06317115,0.029207014,-0.10536539,-0.043702517,0.002964169,-0.0045161494,-0.079660684,0.0936564,0.024573805,0.004712209,-0.023530018,0.091687605,-0.056007408,0.0531696,0.013186452,-0.004306455,-0.08090357,0.06187636,0.007044225,-0.07211055,0.0064892923,-0.022296647,-0.07054452,0.047035314,-0.032499775,-0.05678007,-0.05162923,-0.062534496,0.008364883,0.029724352,0.052114077,0.0016858957,-0.0016030525,0.10700675,-0.00046969406,0.021687444,-0.010458793,0.006688965,-0.00770327,0.023676699,-0.017380314,0.018982597,-0.026941663,-0.0734621,0.02761175,-0.018126853,0.007004514,0.027606519,0.050482035,-0.08222857,0.020649109,-0.07979861,2.9947416e-33,0.007917025,0.005500111,0.06834147,0.021357886,0.040796213,-0.0020572403,-0.09116981,-0.08249029,0.050894715,-0.13191178,-0.03427099,-0.057325173,-0.0056561963,-0.0073607713,-0.08657529,0.071818426,-0.06618374,-0.029677924,0.029679228,0.05072109,-0.06910034,0.121362984,0.05445576,-0.042869803,0.066135794,0.10814128,0.0651764,-0.004773609,0.030293815,0.011463173,-0.0865069,-0.04102253,-0.11325582,-0.051562645,-0.040928245,0.03614259,-0.0503825,-0.06312164,-0.020419355,0.026006978,-0.026650218,0.021427127,0.02132769,-0.0063470863,0.03300077,0.011083218,-0.08498516,0.06835557,-0.033880584,0.022810858,-0.007412849,-0.027351085,0.04517645,0.005381988,-0.07737287,-0.02134968,-0.018733263,0.0015186693,0.061097834,0.0007088134,0.09225759,0.027274655,-0.024837716,0.036716986,0.0149086695,-0.01321919,-0.018043503,-0.022930546,-0.0051533706,0.021864062,-0.05345546,0.026952801,-0.002124394,0.033128254,0.027350709,-0.07736795,-0.0033129402,0.040385198,-0.049070243,-0.002110685,-0.050909113,0.012627472,0.07581963,0.0052736867,-0.032094225,-0.055840608,0.035514913,0.017443476,-0.042804956,-0.017220808,0.0321729,-0.083262846,0.009697389,0.13228525,-0.12557031,-3.4253832e-33,0.02734982,-0.049029563,0.059557483,-0.020666039,-0.10522007,0.030630153,0.020139292,0.07097205,0.014266898,-0.03659026,0.046925765,-0.048378758,-0.0104756225,-0.06297844,0.058387548,0.06688778,0.02136453,0.024606878,-0.03691003,-0.043037377,-0.048276223,0.02724104,-0.063101426,0.016301518,0.0024569137,0.021238783,-0.037218943,0.024684964,-0.022791918,-0.017255394,0.0018782417,0.048925098,-0.08888499,-0.059992976,-0.049985852,0.03726055,-0.010120938,0.009563542,0.06394654,-0.050796438,0.08961834,0.06988877,0.0030842847,0.10850305,-0.022955153,0.039899178,0.0006305979,-0.01365786,0.07269015,0.031231618,-0.0069750864,-0.12707323,-0.0034213995,0.013309154,0.018292798,-0.091044046,-0.015798988,0.039272893,-0.027924888,0.0034785832,-0.0011483113,-0.04583202,0.031959664,0.10579818,-0.007870288,0.065373145,-0.09339465,0.016015878,0.065894924,0.00501819,0.055146758,0.0018942364,-0.00015324733,-0.020688744,0.0014751004,0.055850834,-0.08125494,-0.05635095,-0.006843987,0.006015574,-0.08299765,0.011415484,-0.051485755,0.016589887,0.019518986,-0.09587348,0.10041031,0.06558795,0.011358616,-0.03029964,0.044012822,-0.010122979,0.063195616,0.056155123,-0.0031670174,-3.0411456e-08,0.11161943,-0.06264398,0.057378605,-0.029639449,-0.091499895,-0.03090654,-0.0596796,0.029858831,0.0494787,0.0010493834,-0.00040620533,0.05580349,0.010747816,0.03664361,-0.05262426,0.08945083,-0.12659718,-0.02771648,-0.016715541,-0.077911705,-0.089560404,-0.05176347,-0.025349503,0.067988284,-0.0056927395,0.029693378,0.030979186,-0.030296383,-0.054329313,-0.053244706,-0.03128918,-0.017041458,-0.096287936,-0.004054679,-0.034572735,-0.0043438654,0.010704308,-0.016305098,0.016275963,-0.017967686,0.073777996,-0.050232615,-0.0079422295,0.0041443883,0.011255869,-0.04440124,-0.0384867,0.04485119,0.009503407,-0.03660304,0.06852992,0.02287109,-0.044249784,-0.0326344,-0.15527265,-0.03554372,0.0042714784,-0.0034439156,0.041992936,-0.055919234,-0.01030551,-0.053158417,0.11439754,0.06843237 +3.4.24.27," A thermostable extracellular metalloendopeptidase containing four calcium ions. Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus [4] and Aspergillus oryzae [5]. Type example of peptidase family M4. Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin",384,1.0,-0.024002383,-0.08967234,-0.10220712,0.029402057,0.090281665,0.01456801,-0.037555758,0.03699681,0.044831794,0.031034458,0.035366487,-0.084148206,0.011816369,0.10511096,-0.050857868,-0.0809196,-0.08423175,-0.028433332,-0.026855135,-0.06364835,0.09677311,0.006825708,-0.05027015,0.020253496,-0.014835554,-0.018821176,-0.010686275,-0.019517649,-0.038375225,0.032610986,-0.056715686,-0.03221757,0.032255676,-0.080639705,0.12714611,0.027054867,-0.005699366,0.043866687,0.024676973,-0.02703171,0.050701395,0.04295342,0.05981347,-0.01020066,-0.10357028,-0.030118564,0.0031314818,-0.037516505,0.07456927,0.0038553854,-0.0032524143,-0.06770869,0.0017718334,0.03187059,0.018682418,0.013404774,-0.01829661,-0.03684002,0.03329244,0.016021617,0.08017747,-0.016440086,-0.009452161,0.013439458,-0.041586295,0.01930954,-0.003082242,-0.008773479,0.004884591,-0.048858207,-0.027397597,-0.050406337,-0.042524878,0.048798304,0.043508995,0.07327339,0.05179088,-0.053260647,0.020974042,-0.0324232,0.010980898,-0.025450386,0.048342466,0.0056113843,0.018088061,0.023600196,0.10457129,-0.03367903,0.037262965,-0.007543127,0.037176263,-0.029462239,0.015062367,-0.058995634,-0.038318314,-0.0031522631,0.024912434,0.0008752094,0.035890467,-0.057140637,0.017070498,0.010975502,0.03778279,-0.02441313,0.07946563,0.067735195,-0.028211022,0.022788614,0.116436355,-0.010119188,0.042481933,0.022431921,0.027324855,0.017527651,0.075311825,-0.003523173,-0.012393355,-0.044576384,-0.06407643,0.045557257,-0.015515584,0.032344833,0.040833518,0.00429408,-0.0019437328,0.027757844,-0.063816406,6.2943285e-33,0.016359521,0.020331858,0.037999697,-0.046727892,0.091315605,-0.05536377,-0.04856831,-0.0002146762,0.046736367,-0.03653795,-0.047024243,-0.030976195,-0.058394883,0.030727085,-0.05596222,-0.015178298,-0.02541928,-0.07039707,0.03848198,0.074851505,-0.036029078,0.11443461,-0.01996127,0.0133050345,0.12104237,0.10079961,0.028052606,-0.010158672,0.054531988,-0.015971646,0.004465568,-0.08656079,-0.15822826,0.008737235,0.070768684,-0.01659028,0.055930596,-0.05348708,-0.0012061981,-0.00841584,-0.0091576725,0.0076757763,0.011989022,-0.017308844,0.06880038,-0.037414707,-0.11171523,0.06787787,-0.041176967,0.02351335,-0.014065328,0.011762962,0.10426065,-0.0075656744,-0.069877684,-0.012776864,-0.015233383,0.01528155,0.061940193,-0.006699598,0.059097502,0.039867617,-0.017428806,0.021773286,0.033072907,-0.01938228,-0.044577405,-0.04268313,-0.001523294,0.056570783,-0.05954661,0.028290803,0.006166372,0.005243857,0.07045897,-0.08153987,-0.018044129,-0.0019045701,-0.025928615,-0.030345984,-0.04298156,0.021945272,0.055760086,-0.014751428,-0.093713194,-0.05244705,0.0070440224,-0.0033285026,-0.049192335,0.030112622,-0.039516922,-0.015993288,0.013312309,0.13209991,-0.11288584,-6.460358e-33,0.091080785,-0.052908204,0.10395477,-0.053751167,-0.090803474,0.07030992,-0.0038821013,0.050537493,-0.013435135,-0.082542144,0.060187295,0.004124324,0.040023148,-0.070136055,0.010352444,0.121113665,-0.033241104,0.084015906,0.019352464,-0.01848597,-0.06274058,0.051586974,0.0031899044,0.002607621,0.10244739,-0.002650088,-0.0066632857,0.034384955,-0.012086464,0.018210117,-0.032131843,0.0782057,-0.01068679,-0.094413176,-0.12188976,0.0033623048,0.030672707,-0.036340833,0.06521514,0.056980815,-0.020939134,0.031479917,0.0297169,0.11049918,0.0018801145,0.047679096,-0.07083131,0.027982958,0.012058384,0.012657126,-0.022978578,-0.1061778,-0.05680221,0.037921943,0.007281941,0.0071197418,0.056215174,0.05430663,-0.046375073,-0.0056728143,-0.021244785,-0.050824277,0.054326247,0.06585795,0.04040293,0.06829436,-0.09333775,0.00089751295,0.05796163,-0.0034110793,0.08536467,-0.03856178,-0.008768994,-0.015182859,0.030469118,0.013906792,-0.016395826,-0.06294517,0.0045939344,-0.023092888,-0.042066406,0.09443084,0.038288776,-0.039183263,-0.008244991,-0.10424435,0.09305918,0.07124657,-0.027618084,0.02579612,0.02731595,-0.01746152,0.027093953,0.043102827,0.061649542,-3.899207e-08,0.07097961,-0.018107248,0.056420065,-0.086779766,-0.0554844,-0.0424683,-0.049413867,-0.010839875,0.03407629,-0.014562533,-0.005857917,0.0033095442,-0.052373737,0.048575096,-0.029466186,0.072992295,-0.093799576,-0.021943487,-0.005137231,0.015369889,-0.06685461,0.0072968476,-0.09918892,0.05112509,-0.014745927,-0.015919793,0.008161387,0.019212436,-0.042545754,0.039189223,-0.081534415,0.05018852,-0.058471344,-0.11824711,-0.0463574,0.009954261,-0.031035483,-0.05156543,-0.031756986,-0.06307601,0.008587756,-0.08283158,-0.020115232,-0.027624086,-0.028266268,-0.08899736,-0.0033748266,0.038905844,0.061148547,0.0027112472,0.04410996,-0.003029303,-0.019712605,-0.09649415,-0.11670176,0.026461018,0.037368327,-0.017308565,-0.0068489593,-0.05599241,-0.017968763,-0.04350437,0.13776396,-0.027197031 +3.4.24.28,"Variants of this enzyme have been found in species of Bacillus including B. subtilis [1,6], B. amyloliquefaciens [5], B. megaterium (megateriopeptidase, [2]), B. mesentericus [10], B. cereus [3,8,9] and B. stearothermophilus [7]. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4",384,1.0,-0.03338499,-0.0301115,-0.05934217,-0.038934313,0.038391583,0.019455273,-0.093571894,0.08019306,0.039826035,-0.01671329,-0.0047455733,-0.08715175,0.04362325,0.10157799,-0.06256072,0.056560855,-0.059440073,-0.030932808,0.01225089,-0.041886356,0.0831417,0.056081843,-0.014638204,0.029387219,-0.01639351,-0.04124301,0.040854122,-0.05458682,0.00023427789,-0.004665389,-0.036128018,-0.039736085,0.094977334,-0.023105886,0.10407512,0.03313602,-0.03485596,-0.0126117,0.101863906,0.02414722,0.04498913,0.022978224,0.022409681,-0.050057366,-0.02685437,0.007055576,0.031745397,-0.018941935,0.057004154,-0.031129727,-0.061996404,-0.08912977,-0.013848001,0.062104266,0.035206694,-0.05085299,-0.031091545,-0.04946759,0.011364511,0.01930995,0.057248652,0.016975582,0.060376022,-0.028636679,-0.052806262,0.020762403,-0.00511926,-0.050929554,0.009723805,-0.050937183,-0.016412947,-0.041785747,-0.0037249704,0.054304432,0.024259016,0.034152374,-0.0069516595,-0.052545197,-0.026796864,-0.026970243,-0.013295525,-0.06708759,0.015562154,0.07118793,0.046961427,-0.014250395,0.09299998,-0.022681125,0.029024275,0.014302076,0.05382648,-0.06837058,-0.022769902,-0.035871908,-0.06524342,-0.049702056,-0.06585893,-0.016428392,0.07691501,-0.052119736,-0.01575177,-0.01464438,-0.050592985,-0.018052354,-0.03013191,0.042735834,0.050720327,0.047054213,0.15372847,-0.04317291,0.028208314,0.017690001,0.0207223,0.002906614,-0.0014667436,0.023928039,0.0074630724,-0.025068238,-0.025421789,-0.018399557,0.0313536,0.009295649,0.07665322,-0.011687954,-0.03163963,0.10003009,-0.13270563,1.7372131e-33,0.023512987,0.009311859,0.06733177,0.011549093,0.009913084,-0.013289609,-0.06034158,0.008053821,-0.0069186063,-0.1168161,-0.102314904,-0.08286032,-0.021445666,0.038245652,-0.012863434,0.006949206,0.017586365,-0.046240505,0.031954337,0.028399102,-0.0064537902,0.07139534,0.005661796,-0.0013233686,0.07791586,0.06508077,0.10424819,-0.004966601,0.09229113,-0.0066563743,-0.049722444,-0.09377517,-0.13081531,0.0024358886,-0.005412015,-5.5731944e-05,-0.022133807,-0.05668393,-0.043096267,0.014993021,-0.041314404,0.033968497,-0.006009335,-0.0599869,0.07766769,0.0007429882,-0.059707988,0.07130309,0.048671175,0.010176729,0.01585147,0.0062340014,0.07023898,-0.04147656,-0.05163313,0.014634992,0.0013576427,0.05355054,0.090648025,0.0066288235,0.049851824,0.032845076,-0.017820604,0.054008372,0.03687233,0.046070307,-0.022759294,0.0024928306,-0.044564854,0.05164883,-0.030235803,0.03363429,0.06493412,-0.015002991,0.035791904,-0.07379067,-0.0517689,0.00064618065,-0.029148908,-0.05281316,0.019936902,-0.00041660547,0.07890572,-0.023162736,-0.047586065,-0.013712891,0.016125096,-0.022039134,-0.004976264,0.07976791,-0.039595626,-0.085393526,-0.028954133,0.103009805,-0.14376682,-1.2287225e-33,0.06210922,-0.07636236,0.10573281,-0.0619737,-0.1083585,0.046936534,0.033699613,0.061959006,0.02056189,-0.03179393,0.04609462,0.010646156,0.07587818,-0.07946597,0.04540311,0.07651106,-0.025450952,0.03560227,0.03307126,-0.015379195,-0.042945683,0.075802825,0.00094411377,-0.034804553,0.011234895,0.016464802,0.02720136,0.112775885,0.026288299,-0.07478363,-0.044937268,0.06346848,0.015090166,-0.102301344,-0.111929566,0.02643568,0.0032363385,-0.04856008,0.065553725,0.011278628,-0.05157346,0.052514493,0.03282556,0.058579654,0.019318184,0.05216291,-0.017638022,0.0103729665,0.08784139,-0.0062969117,-0.021403797,-0.113764,0.0025824597,-0.063372806,0.028345307,-0.030526593,-0.06504051,0.07663686,-0.0421187,-0.052882884,-0.007139329,-0.056634016,0.0643676,0.045172486,0.016679253,0.1166892,-0.049537018,-0.017843481,0.05070216,0.028436838,0.06702073,-0.01952378,0.0074309846,0.045373864,0.029789956,0.029276887,-0.09955325,-0.03894953,0.0313091,0.0010536114,-0.04368631,0.024321703,0.0015380752,-0.026218193,2.993012e-05,-0.075606525,0.06532186,0.07097973,0.015916733,-0.028699309,-0.024876002,0.017885199,0.048680898,0.0018237517,0.04523877,-4.202191e-08,0.15149203,-0.09235863,0.033418264,-0.035505533,0.016955387,-0.09426601,-0.051992863,-0.015900286,0.018052526,-0.020264726,-0.00683099,-0.01001537,-0.022874054,-0.0006582928,0.0040274165,0.023994138,-0.034839667,-0.0564163,-0.0026937728,0.035039123,-0.08436592,0.018345859,-0.04842762,0.030727804,0.024845587,-0.06358887,0.01564793,0.00743099,-0.04910976,-0.031094907,-0.04396545,0.03907158,-0.02781989,-0.05882699,-0.009426523,0.016638007,-0.08816754,0.0325085,0.06541374,0.021878142,0.1288263,-0.07813374,0.010444047,-0.0013297444,-0.008688571,-0.053513516,-0.097088814,0.010847946,0.012695096,-0.0058915108,0.031062607,-0.0058564204,-0.027907161,-0.00948895,-0.07364634,0.028167088,-0.0051538623,-0.0562639,-0.003518941,-0.07566236,0.08155659,-0.019889267,0.14470606,0.028404864 +3.4.24.29,A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymic activator of plasminogen).,384,1.0,-0.049412895,-0.10084395,-0.080730766,0.02459944,0.022803416,0.020216206,-0.01914501,0.06734916,-0.033600528,-0.024673456,0.033798184,-0.07654124,0.0028744393,0.06712336,-0.038856722,-0.029992273,-0.040832415,-0.013438453,0.035113733,-0.005937607,0.109892,0.022553554,-0.015433278,-0.053409338,0.02845042,0.033220157,-0.062062837,-0.0680666,0.026546186,-0.016980702,-0.004790777,-0.017818227,0.0492735,-0.034046266,0.07277945,0.03457462,0.015748113,0.04229119,-0.033580396,0.015366497,0.015460406,0.07257618,0.019987883,-0.011960626,-0.080692925,-0.042412203,0.029587723,-0.0007552013,-0.034158766,0.0348323,0.034986977,-0.12541012,-0.048472803,0.012014702,0.019960983,-0.0018248477,-0.052012235,0.03589263,-0.025927491,-0.025644982,0.052175414,-0.010870803,0.07673001,-0.034974746,0.036290575,-0.031830333,0.0074556614,0.0040759966,0.040424723,0.037188377,0.0023706364,0.01113992,-0.0138318995,0.025884341,-0.010570056,0.002738929,0.04394758,-0.03392507,0.03287343,0.024715992,-0.049226347,0.05615571,0.022865457,0.09858688,0.03398127,0.07508621,-0.012524931,0.017381836,-0.0005521492,0.062339436,0.022127746,0.02785349,-0.023748796,-0.01430592,-0.0376743,0.04089704,-0.030601766,0.016536398,0.011022744,-0.039838463,-0.0011266206,0.04233755,0.020694092,-0.07162645,0.06361076,-0.028212039,-0.063121684,-0.009460157,-0.028839111,-0.0035442305,0.056944493,0.06852333,-0.001498146,-0.03347781,-0.017739313,0.015530199,0.04585753,-0.1060296,-0.0831695,-0.0450192,-0.037583157,-0.033469055,0.0050355745,-0.013804828,-0.007429584,-0.038107432,-0.03903184,3.9551183e-34,-0.057908233,0.0061137495,0.049178604,-0.048249565,0.11723075,-0.0363715,0.007703996,0.040572993,0.03289178,0.02829682,-0.10092064,0.00032574817,0.033759113,-0.05323882,0.03464074,-0.05309411,0.0028092575,0.00040680496,0.061183862,-0.023433689,0.056691166,0.016263176,0.0066827275,-0.04852974,0.024480099,-0.005256862,0.023701051,0.03499131,0.14057387,-0.022774309,-0.01637118,-0.05936303,-0.03200658,-0.0939354,0.062348686,-0.031355146,-0.025789877,-0.0489664,-0.008295712,-0.034255683,0.042761855,0.0036906525,-0.0503859,0.05978663,0.043393143,-0.07830486,-0.18486588,0.0803346,-0.017091502,0.024400638,0.024116801,-0.02786488,0.10424401,0.019042596,-0.07481858,0.037306044,-0.009576549,0.028950596,-0.029118456,0.07725437,0.006480622,0.002358467,-0.04098801,0.02430876,0.005852119,0.011834375,0.0012929194,0.020526124,-0.024926309,-0.00053269614,-0.049535975,-0.04928541,-0.023696367,-0.0027572608,0.018046599,-0.019635975,-0.01107015,0.03105137,0.07645326,-0.011142096,-0.03867189,0.02629602,-0.02547254,-0.081109546,-0.10158754,-0.0457085,0.010705398,0.015444961,0.017751703,0.03339707,0.0687943,-0.04281862,0.008608021,0.1214389,-0.05379417,-1.9972472e-33,0.053687423,-0.09085701,0.086889714,-0.10012509,0.015448027,0.09122658,-0.012505293,0.033533517,0.0004142133,0.009390075,0.023296904,0.036399547,-0.013855309,0.037876032,-0.002212667,0.05021133,-0.020680217,0.11275778,-0.0025080226,-0.012274279,-0.08164711,0.09486657,0.0340392,0.04471586,0.0017978761,0.035098713,0.0015705564,0.05414028,-0.06723936,0.044774063,0.03497126,-0.041126113,-0.04363305,-0.06300907,-0.10460311,-0.0067323297,0.05616723,-0.013704458,0.07898828,-0.008226011,-0.0017761487,-0.0076167886,0.007715337,0.13859004,0.080178544,0.12719685,-0.18314926,0.0714713,-0.06098274,-0.01176581,0.007919971,-0.03972528,0.010527729,0.029266633,-0.019216087,0.00722474,-0.030646464,-0.031315833,-0.002558058,-0.008826265,-0.0034747573,-0.1166908,-0.09174011,0.06735961,0.021579646,0.0068527665,0.019194175,0.0075739957,0.023720874,-0.09284496,0.054324884,0.06373834,-0.095102936,0.017647017,0.0049174917,-0.017654037,2.9817818e-05,-0.08264798,0.016663471,-0.095058985,-0.014010835,0.035415422,0.059072245,-0.05207693,-0.0030042357,-0.06289395,0.12245092,0.06834291,-0.019266985,0.014599939,-0.084886484,-0.018355543,-0.04681422,0.05986752,0.07981856,-2.8980784e-08,-0.01639444,0.013310098,0.06032777,-0.04373302,-0.036071856,-0.028509643,-0.04358995,0.054045383,0.055055253,0.0041160197,-0.041812383,-0.032073002,0.008150576,-0.0030120967,-0.002644895,0.023709653,-0.0044537606,-0.004736958,0.026863467,-0.03400435,-0.03388494,0.03231949,-0.018472334,0.08110996,-0.014658912,-0.004509477,0.050889578,0.09753941,-0.1357487,0.034277923,0.0061276057,0.03841745,-0.005164205,0.054915298,-0.095132865,-0.0042746086,0.075706825,-0.07089883,-0.0052904245,-0.009301096,0.008730233,-0.0035515842,-0.04646826,-0.04459695,-0.039268006,-0.009389907,0.019985786,0.0787615,0.043131184,-0.048805237,0.07446589,0.0050622933,-0.07389719,-0.07310678,-0.11980501,-0.059763454,-0.018049344,-0.055849064,-0.039060008,0.029443143,0.052264944,-0.07512233,0.17620496,0.013290645 +3.4.24.30,"A 30 kDa endopeptidase found intracellularly in S. thermophilus [1] and S. diacetilactis [2] and in the medium of S. faecalis [3,4]. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4",384,1.0,0.048097312,-0.06078231,-0.13027368,-0.031698275,0.06352496,0.072055444,-0.0111077335,0.035647914,0.058872312,0.07915925,0.062204942,-0.0868842,-0.04911796,0.11268758,-0.054377824,-0.03196649,-0.052454267,-0.07118049,-0.018030578,-0.04533222,0.09623451,0.04869704,0.029108735,-0.015260103,-0.028630445,-0.03403915,0.012922251,-0.068575144,-0.03366374,-0.008946783,-0.016238064,-0.06466393,0.054454103,-0.0076105245,0.10979496,-0.011407333,0.0009742402,-0.009361961,0.07559695,-0.014350531,0.06310326,0.014808707,-0.023120863,0.02051238,-0.03003745,0.055339847,0.012458424,0.015095094,0.056273274,-0.021466956,0.031364713,-0.08819727,-0.0077342223,0.05241564,0.010884379,0.05771057,-0.015571867,-0.04798362,0.003140312,0.020466775,0.103605986,0.01109676,-0.01598259,-0.001155451,0.0007030606,-0.094870344,0.064066656,-0.021541618,0.017281827,-0.03517998,-0.0087152105,-0.057594992,-0.037937954,0.08780301,0.03020111,0.062782735,-0.024164587,-0.07319776,-0.016147716,-0.032045085,-0.0026465422,0.003683495,0.09039931,0.059634738,0.014735394,-0.026398154,0.06444192,0.022377502,0.0164662,-0.0024574643,0.006773539,-0.10045159,-0.0044946726,-0.013214572,-0.008493994,-0.06259028,-0.007709582,-0.013376252,0.02940787,-0.08004276,-0.058782317,-0.043348998,-0.01930002,-0.05632779,-0.019776972,0.074103765,-0.07296871,-0.0036818308,0.099846005,-0.049237855,-0.001166533,0.024142854,0.028208954,-0.040553726,0.11706785,-0.028166298,0.043719072,-0.04117722,-0.029882928,0.057169657,-0.012288533,0.024132384,0.055480562,0.09631835,-0.04465553,0.08486873,-0.028173782,1.6752092e-34,-0.0028057783,-0.009982928,0.039865114,-0.046124935,0.03247797,0.0060506477,-0.0086576445,0.0034005828,0.016131436,-0.04375267,-0.08727494,-0.055081073,0.008999363,0.020435669,-0.052251354,0.048604995,-0.016304636,0.016649408,-0.00036181486,0.025634876,-0.025077699,0.12585554,0.044038855,-0.062273778,0.07284875,0.077287644,-0.0034828824,-0.02247307,0.13267007,0.0046540997,0.019621586,-0.117516674,-0.09735456,0.049577758,-0.009639938,0.056786682,0.05842522,-0.06221078,-0.03722632,-0.021048054,0.005057731,-0.006228445,-0.013280676,0.003845416,0.031412534,-0.07282828,-0.050338466,0.068341106,0.020310324,0.0054751793,-0.042478446,-0.041568633,0.077552594,-0.050280802,-0.03770872,0.026939325,0.01878421,0.019082211,0.08798113,-0.0025482995,0.029912913,0.045284364,-0.061642572,-0.0022924296,0.026892092,0.005243946,-0.04318164,-0.015781263,-0.042614173,0.02453712,-0.10187679,0.020012751,0.023658052,-0.00643307,0.074076414,-0.07763557,-0.0899641,0.008548565,-0.030160453,-0.013044077,0.04102876,0.013334361,0.028089333,-0.008752341,0.008514292,-0.027861223,-0.026587313,-0.015748866,-0.07620967,0.09716564,-0.02433825,-0.0319611,-0.034685954,0.11126033,-0.06586896,-1.3805291e-33,0.0520047,-0.049882222,-0.01925756,-0.026457038,-0.06275834,0.08343995,0.002898414,0.089311175,-0.015515192,-0.046734247,0.077978365,-0.05743211,0.05830009,-0.055071805,-0.017537123,0.017568769,-0.0060287383,0.111932464,0.03996113,-0.090662114,-0.11689457,-0.003236806,-0.008729303,-0.017431207,0.06439594,0.02646989,-0.03612323,0.06986332,-0.073757,-0.0039586695,0.028157715,0.020857641,-0.047898173,-0.07205911,-0.071658015,0.024455389,-0.08226428,-0.042212147,0.08956863,-0.029801514,-0.019156432,0.028196147,0.056414858,0.08316168,0.018623842,0.010458087,-0.091034636,0.0532747,0.073571846,-0.016983308,-0.00013110501,-0.08300316,-0.031488616,-0.01786996,0.015054432,-0.012822615,-0.0007117491,0.053679317,0.015273384,-0.0465248,-0.011624431,-0.054890092,0.07409061,0.06933731,0.061251413,0.04775819,-0.1076116,0.06510438,0.06471484,0.0127660865,0.0253459,-0.02534512,0.00086378446,-0.025465878,-0.00366422,-0.0008568209,-0.06908831,-0.00512872,0.0993337,0.012753446,-0.0474802,0.020878114,0.038031835,-0.032216027,0.06751352,-0.10364819,0.054338437,0.06986814,-0.004762431,0.025702732,-0.029205028,-0.022160498,-0.0039197737,0.013749682,0.069362625,-3.8523602e-08,0.16863716,-0.04117284,0.0801372,-0.07086467,-0.0076383776,-0.017094836,-0.0009581844,0.053274583,0.022235617,-0.049065355,0.03277033,0.017241705,0.0034557907,0.06873122,-0.010082418,0.013326831,-0.009072594,0.022445649,0.014051869,-0.039120864,-0.06403932,-0.033582006,-0.0566892,-0.00031542368,0.03003873,0.010945446,-0.012905042,0.013880658,-0.02090415,-0.0053368765,-0.011147719,-0.023381306,-0.07913455,0.011467333,-0.03920684,0.07520522,-0.0543907,0.040731005,-0.012690603,-0.015471054,0.020044114,-0.05824791,-0.00296505,-0.010551791,-0.013608802,-0.038664993,0.055813752,0.047444712,-0.051402096,-0.0432454,0.037093636,-0.053647324,-0.0514286,0.00075545366,-0.14410795,-0.050638676,-0.0007501687,-0.0696466,-0.02911743,-0.066544175,-0.079731554,0.0073790425,0.12169995,0.07064822 +3.4.24.31,"The enzyme has been characterized from the bacteria Streptomyces griseus, Streptomyces naraensis, and Streptomyces cacaoi. Specificity is similar to that of thermolysin, but the enzyme is much more sensitive to inhibition by sulfanylacetyl-Phe-Leu. Little structural similarity to other bacterial metalloendopeptidases. Type example of peptidase family M5.",384,1.0,-0.05058179,-0.08603073,-0.15503863,-0.005765549,0.05716858,0.046142958,-0.085632265,0.060697522,0.040131938,-0.02756986,0.0021814848,-0.042908497,-0.0020948001,0.06735509,-0.06317886,-0.072756425,-0.051724028,-0.03607752,0.013299344,-0.08048749,0.12767208,0.033646446,-0.04232095,-0.009897957,-0.0042071757,0.023316404,0.033305846,-0.0032639303,-0.05417878,-0.024180543,0.02072511,-0.032500137,0.06206069,-0.059573866,0.104372844,0.045997825,-0.030355453,-0.012621179,0.06662968,-0.013648394,0.00762577,0.05612445,0.015291202,-0.019862084,-0.0133709395,-0.048942342,0.012794635,0.06306924,0.03310766,-0.061033018,-0.017785449,-0.08696512,-0.05244456,0.03424691,0.032743644,0.0071435757,0.015644068,-0.039855618,0.06634509,-0.058197513,0.054238234,0.011529178,0.014896935,-0.035982408,-0.06630477,0.0013076869,0.0034651316,-0.07373873,0.056378238,-0.023045767,-0.06741544,-0.05240256,-0.043714825,0.091184765,-0.013892925,0.089201614,0.049676985,-0.048874605,-0.03377269,-0.020383004,-0.031209532,0.011610482,0.076390825,0.047565345,0.028549328,0.006788417,0.09237494,-0.0017369799,0.09358939,-0.019302124,0.05331359,-0.039103962,-0.028311415,-0.036628094,-0.096772745,-0.011027694,-0.068255775,-0.008537057,0.0064270934,-0.030032117,0.021711342,-0.00645888,0.02583796,-0.021187535,0.024195714,0.081622146,-0.015470129,0.058437023,0.08870171,-0.041552696,-0.016905878,0.038496714,-0.010463485,-0.015693681,0.0396715,-0.018443136,0.06742226,-0.04143109,-0.045267984,0.012159095,0.035613313,0.023995178,0.0418242,0.003540406,-0.041867435,0.012716751,-0.11239046,5.6889654e-33,0.002270472,-0.020688044,0.08661129,-0.058205154,0.05973118,-0.039319243,-0.09104129,0.028839257,0.0713948,-0.03975905,-0.08553045,-0.06250489,-0.018675268,-0.041561298,-0.032883264,0.036723338,-0.061263066,0.008327931,0.035683163,0.050024383,-0.028289523,0.10737233,-0.012877125,-0.03509211,0.12789902,0.060947627,0.027545728,-0.023200609,0.067286365,-0.027767494,0.010411029,-0.10046826,-0.10379767,-0.02746608,0.037005804,-0.021211656,0.01626473,-0.04856137,0.01801842,-0.029535063,-0.006678756,0.041108515,0.012916238,0.049446966,0.05980363,-0.023511145,-0.084277324,0.053963285,-0.011481211,0.063157395,0.011823445,-0.015766129,0.089127146,0.03092431,-0.07361719,0.024117716,0.0203397,0.08157374,0.13478278,0.032019656,0.05606288,0.035852093,0.014873832,-0.024304224,0.045099683,0.03622052,-0.059230544,0.011123368,0.020916568,0.11636198,-0.10638309,0.030326106,0.011772433,0.021340406,0.025210492,-0.11451251,-0.01505777,0.012181677,0.01659003,0.037957177,-0.0707728,-0.01813534,0.0100233285,-0.06826415,-0.097201124,-0.00028919007,-0.055005573,-0.027077315,-0.035327353,0.03581924,0.012518721,-0.012567234,-0.03304319,0.11259735,-0.037455413,-5.7091193e-33,0.081680484,-0.08464018,0.12464185,-0.04294812,-0.089813724,0.042785782,-0.047863137,0.022090156,-0.04779332,-0.063088186,0.062796816,0.016170021,0.021013986,-0.034805454,0.02146943,0.07270553,0.0032400207,0.068922736,-0.008183134,0.032558296,-0.025465297,0.07538953,-0.007575945,-0.043322433,0.038679365,0.005138826,-0.02730803,0.021680595,0.019790117,-0.02565469,0.01987451,0.039628383,-0.051299166,-0.116237566,-0.11000637,0.01042865,-0.04194429,0.029193139,0.06260133,0.029638864,0.015914561,0.06622575,0.018805927,0.14494613,-0.014648363,0.06591086,-0.057161927,0.03386347,0.035055697,0.0015697433,-0.008051271,-0.044715356,-0.044253625,0.00821389,0.0326927,-0.034674723,0.024644082,-0.0016163699,-0.07376351,0.020259501,-0.011833675,-0.049505353,0.017963579,0.022161663,0.06245029,0.0662899,-0.068601035,0.034624584,0.09477739,0.0024674186,0.04517807,-0.043845493,0.0071735983,0.018199325,-0.014228575,0.005162249,-0.024731051,-0.0079161525,-0.010396485,-0.017151583,0.00039970802,0.042124033,-0.0029969816,-0.043647535,0.002711285,-0.059343975,0.051406104,0.04965389,0.046213064,0.075413674,-0.01697336,-0.027622527,0.04057544,0.015733989,0.030030731,-3.5894786e-08,0.006380955,-0.080942005,0.06600149,-0.047994908,-0.04761709,-0.024612285,-0.062351175,-0.02839478,0.032557264,0.0024060842,0.03605284,0.011986102,-0.039526753,0.036800228,-0.020176329,0.0510369,-0.0717635,-0.0003608507,0.02756314,0.047365066,-0.08753421,0.008305972,-0.10318052,0.07973196,0.035768226,-0.06755858,0.027855044,0.01863341,-0.09310712,0.016456494,-0.023788018,0.042888187,-0.04200544,-0.01774535,0.012998837,0.018539583,-0.05140287,-0.0052756295,-0.03262428,-0.032473896,0.05411014,-0.06207817,-0.03466142,-0.0054055266,-0.029340869,0.0030771068,0.017562985,0.027058164,-0.008721614,-0.023962341,0.039220467,-0.007930692,-0.026395414,-0.06743349,-0.12706919,0.02912422,0.02680278,-0.06963211,-0.0029388976,-0.062969625,0.036261372,-0.06988411,0.18420357,0.011103348 +3.4.24.32,From Achromobacter lyticus and Lysobacter enzymogenes. Digests bacterial cell walls. Type example of peptidase family M23.,384,1.0,-0.07661864,-0.10474182,-0.14356354,-0.035190165,0.050162252,0.01680932,-0.05383155,0.042757783,0.004235573,0.02620437,0.04162109,-0.06210312,0.023209266,0.061835364,-0.0014670006,0.049178865,-0.056925233,-0.021095943,-0.0041830284,-0.06158817,0.061945483,0.059856694,-0.011221426,-0.026370477,-0.0102289915,-0.06070271,0.02301552,-0.038126595,0.01242703,-0.06609867,0.0030497187,-0.0871005,0.07875017,-0.022884475,0.16307068,0.04044506,-0.021115303,0.014569847,0.14707549,0.01064457,0.03808647,0.051436204,0.014246515,-0.06829862,0.0019078704,0.022284864,-0.027808966,0.0622272,0.044017907,-0.07022299,-0.06275484,-0.027088532,-0.039908305,0.057749577,-0.040194623,-0.007195064,-0.010420544,-0.021888431,0.051077113,-0.0038456747,-0.023697596,0.012001293,0.04729165,0.0020388863,-0.025577204,-0.05390836,0.0009992091,0.008820049,0.0019718253,0.04132796,-0.030533861,-0.04599022,-0.01147575,0.082976535,0.03868639,0.056971602,0.01728934,-0.011052026,-0.09223253,-0.005178495,-0.08060225,-0.050392922,0.05391651,0.07059675,-0.054460738,-0.0704569,0.006463824,0.012600355,0.029403074,0.0022278917,-0.008851131,-0.045551673,0.060804594,-0.017520934,-0.03905772,-0.054737303,0.06372011,-0.06296559,0.05715823,-0.043874305,-0.029357238,-0.0055704885,0.069609836,-0.03459483,-0.009717244,0.016645463,-0.018427571,0.059453726,0.07897538,0.014640987,-0.018413154,0.0148198875,0.005862005,-0.06813048,0.0015972197,-0.032158066,0.06110885,-0.07766491,0.009168188,0.029645987,0.053077854,-0.023739234,0.050663188,-0.01791689,-0.05063844,0.058797903,-0.0811103,3.4335415e-33,-0.00084953377,-0.036326196,-0.0035367974,-0.011897311,0.02003485,0.012709751,-0.036782034,-0.0067086853,0.08800396,0.0057591717,-0.09322061,-0.043624558,0.016406385,-0.011112743,-0.102861136,0.07331993,-0.09437688,-0.03346028,-0.04701143,0.12761754,-0.02450029,0.0655631,0.030571504,-0.013103911,0.081692785,0.012826022,0.09409317,-0.04623712,-0.019023003,0.006126443,0.010218002,-0.07579914,-0.09324543,-0.012344622,0.013779123,0.00012018918,-0.0075699897,-0.060755815,0.00416389,-0.03197646,-0.0065868427,0.045384094,-0.006545395,-0.03301681,0.098511614,0.011227861,-0.057414755,0.051581625,-0.023385307,0.042217784,0.055262093,-0.021380143,0.039736975,-0.022976257,-0.035324022,-0.021695664,-0.0044832746,0.056391854,0.11192324,0.026908861,0.11944693,0.08120844,0.011026397,0.043913364,-0.046416193,-0.014200514,-0.03185899,0.015586888,0.031497605,0.0754927,-0.07179291,-0.034900185,0.02515631,0.048385117,0.05576988,-0.1145114,-0.033339124,0.009319831,-0.025497332,-0.019564146,0.020162944,0.013221868,0.042267796,-0.01785393,-0.07314507,-0.027772965,-0.01840128,-0.0012643337,-0.053304765,-0.010713622,0.014895393,-0.013334835,0.0043840157,0.13696496,-0.102491684,-4.6115415e-33,0.10145884,-0.04783763,0.047724087,-0.09571761,-0.047551412,0.029642312,-0.010596424,0.05592481,0.0094157215,0.0005907627,0.042396467,0.0369926,0.0073467996,-0.028999243,0.09882199,0.0145859765,0.04578061,-0.0055503943,-0.043296937,-0.013101943,-0.054612722,0.0016732719,0.025645442,-0.06559791,-0.0072382656,0.06272111,-0.06429025,0.1122566,0.022760583,-0.024374116,-0.030942274,0.06646232,0.0028311855,-0.08314951,-0.10130619,-0.0014741607,-0.013039877,-0.031807367,0.0051432694,-0.0700274,0.0878248,0.054094113,0.02719091,0.0992947,-0.03369348,0.026945049,-0.028005453,-0.050018422,-0.019390676,-0.045938462,-0.03003798,-0.085230015,0.022692418,-0.023235805,0.008621145,0.012175017,-0.0026090853,0.060871124,-0.023552803,0.01971801,-0.003741335,-0.033181656,0.04366911,0.076661415,0.028065462,0.06394492,-0.034541517,0.005243033,0.04810901,0.047069777,0.03684915,0.060625367,-0.036105245,-0.0074671768,-0.005085982,0.09174465,-0.09970264,-0.104761146,-0.018292401,-0.05767813,-0.041160263,-0.02742811,-0.0039888625,0.045386884,0.0072270567,-0.10616086,-0.024698326,0.054371987,-0.006430611,0.016061839,0.05394572,-0.07655362,0.039114334,0.043699197,0.09193962,-2.823787e-08,0.06146089,-0.046258137,0.053327523,0.0031639284,-0.052170858,-0.039338637,-0.11631944,-0.003906776,0.07116461,-0.003300557,0.032090187,0.0027133976,-0.0045545413,0.036609344,0.02632143,0.057185233,-0.089871146,0.022030314,0.0092987,0.09345269,-0.08416069,0.009748252,-0.035080705,0.09052416,0.024040679,-0.024293296,-0.018749533,-0.02709234,-0.033215363,-0.029104594,-0.0043937555,0.085914336,-0.016124422,-0.039080933,-0.0191497,0.00066211127,-0.0137207955,-0.08219111,-0.02679916,-0.053439632,0.04158746,-0.0337638,-0.08151786,-0.02219229,0.0071626245,-0.0065186163,-0.039281692,-0.017738238,-0.057680007,-0.07963294,0.0074681947,-0.007282454,-0.018702235,-0.036272474,-0.0848686,0.0016916202,-0.036148626,-0.08277975,0.04532375,-0.050484475,0.043113686,0.02950202,0.16620523,0.03003926 +3.4.24.33,A metalloenzyme isolated from Pseudomonas fragi. Useful in protein sequencing applications because of its limited specificity. In peptidase family M72.,384,1.0,-0.08417479,-0.09270059,-0.02025584,0.046810158,0.08887067,0.06926096,-0.063134946,0.06571886,-0.018341493,-0.017762566,0.03262219,-0.06055267,0.00015573822,0.06213653,-0.08829495,-0.011704553,-0.035968788,0.0076631857,0.020252313,-0.0105670495,0.046291538,0.06574372,-0.05394362,-0.029761503,-0.014287091,0.018423557,0.03988082,-0.01205536,0.028464632,0.0049243406,-0.01888016,0.015529108,0.10344913,-0.08113465,0.10996257,0.0029649218,0.034920793,-0.0035484512,0.059568636,-0.0047841687,0.062119722,0.07856412,0.058043655,-0.08185177,-0.01860361,-0.051994532,0.02518571,0.05293943,0.05510434,-0.0022293034,-0.06380983,-0.074451305,0.034500945,0.02876961,0.02583798,0.027214238,0.04304358,-0.046665087,-0.021035342,0.0022340713,0.07118734,-0.039618306,0.012489627,-0.02468192,-0.005883632,-0.032611463,0.020042432,0.027546708,0.09651667,-0.01748678,-0.04437963,0.025696741,0.011632228,0.037139345,0.024982736,0.056534756,0.03761028,-0.07302564,0.019864574,0.029800745,-0.048472855,-0.029788466,0.14602917,-0.010015138,0.04483879,-0.02247278,0.050480265,0.0958537,-0.043139875,-0.028443329,0.025093036,0.013814706,0.0339397,-0.02109886,-0.07378209,0.06455647,0.052427273,0.07290842,0.04614172,-0.017558148,0.03738274,0.04877755,0.047864724,-0.08825112,0.083227634,0.050940026,-0.025634872,0.06121599,0.0681666,-0.029639155,0.025977481,0.029085293,0.043007843,-0.042509805,0.019492516,-0.01936942,0.038737167,-0.047063597,-0.043785263,0.03588717,0.013724923,-0.030697143,0.023675617,0.015190686,0.024150545,-0.018434646,-0.083226055,-6.7559063e-34,0.016382363,-0.018411802,0.017485447,-0.027292103,0.0553658,-0.04997787,-0.021064129,-0.0047400855,0.009782841,-0.01603616,-0.03461958,-0.06437608,0.038419843,-0.06467598,-0.06401096,-0.03696962,-0.04915173,-0.027790766,0.033082366,0.0529383,0.027192183,0.026710656,-0.03727713,-0.060360987,0.09071648,0.037383363,0.028967693,-0.031717237,0.068363965,-0.017264968,-0.023060359,-0.025804838,-0.102414176,-0.040870067,0.05999359,-0.09293867,0.013642967,-0.09478915,-0.09895757,0.014902912,-0.012198837,0.07550487,-0.050051875,0.01257799,0.060653947,-0.062102888,-0.0790387,0.11012368,-0.0036866409,0.027943287,0.011027349,-0.016640497,0.045155395,0.034424268,-0.052696604,-0.024321,-0.050332714,-0.022560125,0.105740495,0.02333562,0.023204518,-0.026221016,-0.06300653,0.07018449,0.030264262,-0.041690085,-0.03061806,0.042915437,0.0368617,0.120896116,-0.030389093,-0.0041676587,-0.0032216301,0.039071813,-0.0035045347,-0.11383582,-0.021106914,-0.030343354,-0.00038497947,0.05375103,-0.020434316,-0.032807775,0.0050730077,-0.02047696,-0.06632261,-0.021851705,0.03929253,0.016835287,-0.04379377,-0.040871166,0.10132944,0.0038646145,-0.05301883,0.107317895,-0.050493244,-2.932496e-35,0.11461615,0.025425386,0.055579856,-0.06986603,-0.088107064,0.010606119,-0.02634653,0.0047621178,0.038165644,-0.043229487,0.10774191,-0.0024419166,0.079032384,-0.038780365,-0.0005329392,0.08592103,-0.010311974,0.0111917835,-0.030321535,0.032136355,-0.056080118,-0.027891755,-0.040797025,-0.0039445483,0.005816292,0.0087547125,-0.04670223,-0.0010581521,-0.05686042,0.116864294,-0.0006414621,0.08431436,-0.04203311,-0.14761819,-0.075920016,-0.025748352,-0.07750154,-0.03802041,0.10139728,0.044553872,0.027732603,0.05820456,-0.056815084,0.092015974,-0.02652983,0.05536063,-0.058882568,-0.015031211,-0.0044501014,-0.07853218,-0.043396432,-0.05568119,-0.022274688,-0.029280419,-0.021774825,-0.028856674,-0.020467814,0.04928081,-0.0099742,0.023661958,0.002721558,-0.020448443,-0.03117458,0.011469151,-9.043506e-05,0.0790356,-0.045884162,0.052349873,0.013094266,-0.031933904,0.028673641,0.08725806,0.05201139,0.10936968,0.001360784,-0.014661962,-0.050339308,-0.01258896,-0.061810132,0.036969066,0.07546078,0.012772157,0.01633696,-0.051940262,-0.0068633067,-0.09040413,0.07008057,0.07424965,-0.07059838,-0.023481555,-0.024924489,-0.054304983,0.019867118,0.05936496,0.040766895,-2.6043443e-08,-0.026713017,-0.07276613,0.0031663417,-0.071244,-0.10278435,0.019150909,-0.052305184,-0.00466905,-0.01736119,0.014944938,0.066066094,-0.008501516,-0.063964464,0.071351446,0.010980647,0.06877914,-0.03769857,-0.061398108,0.0050385143,0.025583353,-0.0857034,0.017435733,-0.009701733,0.043415356,0.00034739406,0.02341642,0.09098794,0.06439478,-0.05150877,-0.05574679,-0.071681395,0.014164861,-0.032502342,0.04983852,-0.075893015,0.045854144,0.0026469526,-0.010298904,-0.020962963,-0.041939016,0.03580224,-0.036046907,-0.08961084,-0.062490635,-0.0034977468,-0.058368772,0.007920455,0.067179576,0.039736114,-0.122741014,0.07762809,-0.041339003,0.012856253,-0.027409665,0.001324351,0.06013706,-0.0043080673,0.009849923,-0.038725097,-0.041326575,-0.040109124,-0.05394705,0.11472568,-0.05122155 +3.4.24.34,"Similar to interstitial collagenase in specificity, but the product of a different gene and highly glycosylated. Stored in the specific granules of neutrophil leukocytes. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.7",384,1.0,-0.090771824,-0.054998662,-0.06631772,-0.07072336,0.0046328846,-0.042595312,-0.0038377524,0.13059282,0.013840696,-0.037508044,0.05069312,0.042496752,0.006457264,0.073931895,-0.08543186,-0.019615581,0.009156167,0.004457609,-0.10759354,-0.049777303,0.055996336,0.0699795,-0.057671484,-0.014748584,0.008851241,-0.00031615302,0.03562436,-0.041486196,0.042618208,-0.013100837,-0.011790333,-0.06554978,0.084752515,0.0044374065,0.11058253,0.014395477,-0.06398707,-0.01758023,0.07299237,-0.0018072147,0.08676636,-0.034994006,-0.015815012,-0.050958943,0.08367544,0.015639432,0.042557545,0.031592816,0.006586334,0.050823435,-0.058330923,-0.04615182,-0.048888713,0.053861886,0.031658724,0.040150553,-0.07654926,-0.0729435,0.030239593,0.077718385,-0.0037207545,0.026969424,0.011702382,-0.0016214846,0.00142599,-0.07608684,0.1208738,0.04958734,-0.019610954,0.005479097,0.0013910183,0.031274382,-0.0423056,0.118265964,-0.013015389,0.062200688,0.013625443,-0.035177633,-0.029106408,0.0063122264,-0.0039170515,0.009299636,0.10812619,0.02458157,-0.025914844,-0.016432814,0.06544594,0.014334247,-0.01827848,-0.088469565,-0.054040242,-0.12128056,0.0047525098,-0.018886406,-0.041442532,0.017833624,0.05072343,-0.0019953402,0.07212729,-0.019571546,-0.045676634,-0.019906104,0.05112448,-0.008512395,-0.10886586,0.0009739158,-0.07787734,0.050596677,0.07137386,0.04881151,-0.05609379,-0.0004487965,-0.007739989,-0.011608073,-0.062753126,0.017414467,0.06886269,-0.02407272,0.055148307,0.010098481,0.021619158,-0.023011113,0.0580501,0.028750252,-0.084188215,0.0862163,-0.029076029,2.1505577e-33,-0.042041745,-0.06945909,-0.0006609399,0.09504018,-0.096663475,0.0065908264,-0.060712256,-0.04326782,-0.007642687,-0.047063764,-0.068819955,0.07009026,0.0032181446,0.07088738,-0.077119775,0.07944728,-0.07083285,-0.049497046,0.049387656,-0.017509343,0.007584685,0.17345023,-0.0045358604,-0.054728933,0.048821222,0.0062517165,0.016780106,-0.056158382,0.04628665,-0.0029788765,-0.003967109,-0.017463215,-0.016885318,-0.03584397,0.03573833,0.08882582,-0.03734578,-0.102526315,0.016938115,0.04207516,0.007882744,-0.021902002,0.036401358,-0.065071754,0.053435992,-0.05945259,-0.053584803,0.029322695,-0.050600085,-0.025784018,0.04012673,0.0070720334,-0.005415507,-0.047707245,-0.064391434,-0.031447694,-0.043622833,-0.018437782,0.08042106,0.07977867,0.017965805,0.014931231,-0.058286533,0.06547902,-0.013406106,-0.005997367,-0.10548333,0.07324756,-0.007920022,0.058710147,-0.024691014,-0.022607587,0.039962076,-0.021402754,0.0152481245,-0.08758293,0.006752723,0.09921181,-0.10134862,0.0048502386,0.0024512503,-0.00832721,-0.034134455,0.00980851,-0.06436802,-0.019576248,0.02777535,-0.022061102,-0.012775584,-0.007809241,0.037668217,0.004175839,-0.07959254,0.07008332,-0.009536055,-3.4979674e-33,0.081255935,-0.10092386,0.03525044,-0.006491786,-0.0035052032,0.027766747,0.08672022,0.026190761,-0.00781142,0.055018734,0.00898034,-0.000973503,-0.012005815,-0.10751051,0.0034004156,0.024764568,0.009865857,-0.001984082,-0.022870163,0.0144696105,0.008817654,0.03841523,0.03014252,0.048562676,0.07722016,0.0026715002,-0.07615686,0.051214535,-0.046723712,0.0008662756,-0.08009126,-0.017437384,-0.023711659,-0.055396203,-0.09883995,-0.013393605,0.033360116,-0.04953595,-0.018946543,-0.098811276,-0.022021437,0.087167084,0.0037050804,0.1460533,0.022621872,0.09121207,-0.042609643,0.0037195715,0.045088757,-0.04272996,-0.017060893,-0.016764566,0.012603639,0.008620583,0.05456281,-0.014108882,0.018866848,0.026018422,-0.038593043,0.0050925734,0.013294921,-0.021119185,-0.034645516,0.00964969,0.08814711,0.060046937,-0.11796879,-0.029707652,-0.03868451,0.0798546,0.039698277,-0.038510982,0.028465096,-0.057713103,0.017390518,0.047292337,-0.05305192,-0.04369072,-0.035045505,-0.03921171,-0.05366822,-0.040616926,-0.007199891,0.029346274,0.009599173,-0.03807744,0.0065473947,0.09235386,0.04954808,-0.032870736,0.008651801,-0.0040509915,-0.03465797,0.043782234,0.038276546,-3.4754425e-08,0.033640727,-0.08988416,-0.009275706,-0.07052861,-0.073136665,-0.025643831,0.0065069254,0.052103266,0.060603987,0.03968807,0.0039688316,0.06893021,-0.02547355,-0.04140397,0.0117086535,0.10072673,-0.007489323,0.006880092,-0.0016256919,0.014326881,-0.043293968,0.008805963,-0.0026842363,0.09372226,-0.031248828,-0.030780366,0.027698984,0.016045788,-0.068745695,-0.016591031,-0.009325946,0.01032526,0.008696205,-0.033158265,-0.0090343235,0.06670063,0.038084786,0.011458724,-0.05022206,-0.058786713,0.06262203,-0.059573825,0.0061587864,-0.027777288,0.055965826,-0.013062183,-0.009189098,0.00041674345,0.028734114,-0.028362762,-0.028499529,-0.031048685,-0.046562016,-0.017331626,-0.07872778,-0.02240076,-0.016673028,-0.08724021,0.083007954,-0.046491224,0.012788716,0.021806778,0.19818401,0.06714629 +3.4.24.35,"Similar to gelatinase A, but possesses a further domain . In peptidase family M10 (interstitial collagenase family)",384,1.0,-0.08675088,-0.07578257,-0.07951229,-0.07551555,-0.040445156,-0.027507469,-0.04971459,0.10633104,0.01565072,-0.016773444,0.028230183,0.0292998,0.017880792,0.08150513,-0.08013659,0.00032221116,-0.034400474,-0.020946736,-0.03111302,-0.029685792,0.014893307,0.06602548,0.00027135972,0.009137144,-0.021478357,-0.0315336,0.057874292,-0.021315379,-0.0074371146,-0.029886898,-0.020579742,-0.027697375,0.055637926,-0.038419873,0.11571081,-0.00275497,-0.02852641,0.0019275977,0.068859406,-0.0037935812,0.10462395,-0.020946762,0.03510938,-0.032870308,0.064387225,0.02565943,0.043436043,0.029823648,0.030817227,0.025017403,-0.11077801,-0.09495275,-0.053129006,0.016977046,-0.020099798,0.059195224,-0.06991622,0.0024626292,0.04814618,0.05318792,-0.023648253,-0.021573598,0.042276952,0.0035028092,0.03175965,-0.079830945,0.06778416,0.08185273,-0.05661359,0.0210981,0.02404711,-0.011908919,-0.051399384,0.110026546,-0.014905884,0.012129147,-0.029228717,0.011577324,-0.028781513,0.014950713,-0.011101669,-0.0022273536,0.049718592,-0.0033720057,-0.023426374,-0.0017771662,0.10262215,0.00054939155,0.009127991,-0.043406896,-0.028976826,-0.102430895,0.013865334,0.010629355,-0.045954973,-0.017083865,0.04270457,0.01731818,-0.016559908,-0.0045949277,-0.007157046,-0.02843418,0.032436192,-0.052010015,-0.02960185,0.032823622,-0.07972235,0.04444118,0.07187672,0.009998195,-0.015874898,-0.012325043,-0.006133123,-0.04199587,0.004963219,0.0029437828,0.05681953,-0.02622297,0.07852739,-0.008946213,-0.0115144085,0.005914142,0.0667947,0.026936112,-0.07969429,0.03845523,-0.115479335,6.5599775e-34,-0.044448666,0.013122863,0.007438203,0.036957443,-0.06252515,0.026645467,-0.07778272,-0.027159082,-0.023757054,-0.040428944,-0.055005156,0.069491595,0.0153224375,-0.036534686,-0.0576147,0.058903314,-0.046898082,0.012272573,-0.00023450011,-0.030985868,-0.042570703,0.1365094,-0.04398502,-0.02897842,0.061048053,0.012026464,0.029901301,-0.07727746,0.0911823,0.002774538,-0.019257737,-0.016618658,-0.054153547,-0.01001927,0.039351955,0.04682592,0.029309034,-0.11242031,0.017607907,-0.016471988,-0.041706853,-0.07041494,0.013130387,-0.041644275,0.04342244,-0.038143076,-0.03890312,0.04942427,-0.06305516,-0.0047324724,0.033796985,-0.03738949,0.06862309,-0.024029052,-0.08870428,0.017773194,-0.032840952,-0.0018779897,0.06679204,0.038509447,0.02684023,-0.010236405,-0.053118,0.05868158,-0.06989284,0.012313962,-0.092895016,0.0074000596,0.043615237,0.068971485,-0.00447273,-0.029640362,0.03538504,0.0029164723,0.03003074,-0.08850849,-0.0020586448,0.031604297,-0.10478273,0.0632896,-0.006603982,-0.022306597,-0.011200517,-0.012702931,-0.051748402,-0.0064636394,0.039184447,-0.006974479,-0.0065241866,0.015605328,0.05473744,0.029682841,-0.024340147,0.118717454,0.019025406,-1.363087e-33,0.11269944,-0.12412899,0.08375912,-0.02652755,-0.024349954,-0.032503527,0.14170866,0.009963055,0.034417126,-0.0127714835,0.008007002,-0.037117925,-0.055446036,-0.10619496,-0.0049594613,0.02623646,0.08177401,-0.031642966,-0.008597848,-0.02116792,-0.068714574,0.066970766,0.014210816,0.042744707,-0.0063876836,0.04946234,-0.044934146,0.0589222,-0.023936203,-0.010286336,-0.0414902,-0.018238334,0.039502796,-0.019130481,-0.11987671,0.035637226,0.038124695,-0.0748914,-0.040444836,-0.05377532,0.0010777985,0.078285374,-0.00257001,0.1770794,-0.011222673,0.09231361,0.024207387,0.071614616,-0.0096296575,-0.017914651,-0.001105646,-0.029554706,0.025111178,0.00013384536,0.042405985,-0.06781934,0.038754016,0.036769975,-0.062394,0.010557253,0.061463058,-0.04083234,-0.0015117876,0.06318831,0.07262233,0.07326468,-0.13809052,0.0053729694,0.023454258,0.066160515,0.06627046,0.0083092945,0.01881033,-0.016038142,0.061490808,0.055976585,-0.039979685,-0.10313482,-0.049484294,-0.11101268,-0.09165491,-0.06433677,-0.0050328034,-0.0007613175,-0.02320232,-0.009877039,0.024328299,0.0850852,0.021456627,0.01180662,0.04704293,-0.0035488242,-0.007971852,0.0666858,0.0129916435,-2.5027687e-08,0.034779694,-0.058250654,0.005196448,-0.09717727,-0.04209307,-0.08360166,-0.015157805,0.032482926,0.07928864,0.03972584,-0.08375116,0.04666154,-0.029157558,0.005908424,-0.0076174117,0.059223905,0.015584375,0.03432475,-0.015569366,0.009338808,-0.039532755,0.045269918,-0.06420061,0.077575184,-0.042107772,-0.0062948153,0.0091595715,0.03432689,-0.0487415,-0.03459145,0.00047348184,0.0061722193,-0.006553341,-0.041755863,-0.028132884,0.08566182,0.07461507,-0.018209768,-0.035259042,-0.042117324,0.07757632,-0.07145147,-0.009084924,-0.04453406,-0.025204666,-0.028149717,0.064680345,0.015476171,0.073272705,-0.04411197,0.0015032766,0.050020773,-0.044702835,-0.06967154,-0.07462711,0.0028016865,-0.013684553,-0.039943576,0.0016482872,-0.020880634,0.05677213,-0.018215835,0.19602403,0.026587436 +3.4.24.36,A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans. Contains consensus sequence for a zinc-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The enzyme can activate its proenzyme by cleavage of the Val100!Val bond. An acid pH optimum is found with certain protein substrates. Type example of peptidase family M8,384,0.99999994,-0.035524935,0.020130677,-0.07961645,-0.11578282,0.020637106,0.0012881908,0.007881677,0.08715121,-0.009282994,0.018548286,0.082052454,0.05831816,0.023011766,0.071860455,-0.05889975,-0.028481673,0.008274295,0.005143582,-0.00032241948,-0.023973987,0.035407968,0.06867285,0.035045754,-0.0196385,-0.07689751,0.022215191,0.096949205,-0.02157624,0.009287822,-0.057959985,-0.08053703,-0.041174673,0.041706473,-0.036525186,0.0065593403,0.03570651,0.016461253,-0.013611988,0.032739036,0.0040030577,0.057939973,0.018795911,-0.036075924,-0.12821566,-0.019077092,-0.05187682,0.060129143,0.036691,0.072256885,0.02682205,0.0012068118,-0.036420982,-0.002183935,0.069219775,-0.059750553,0.001391649,-0.048968125,0.016051207,-0.02136863,-0.02152648,-0.011686455,0.05126963,-0.024159063,-0.032578077,0.043497317,-0.12028102,0.046825238,0.08272355,-0.051700674,0.05676358,-0.0018693026,-0.032819517,-0.02155749,0.049648535,-0.057175677,0.09461634,0.037711754,-0.032971364,-0.0017155679,-0.021496076,0.03651142,0.002137321,0.078380466,0.08112412,-0.00020419662,0.0050958386,0.050796643,0.06721324,0.115562655,-0.0048414604,0.029845085,-0.05714107,0.00017907444,0.022524659,-0.11114565,0.0142075205,0.019652791,-0.0564797,0.020594161,-0.010697234,0.09538928,-0.037604988,0.05889626,-0.04662819,-0.021214768,0.08333212,-0.03360132,0.09588724,0.024281245,0.007779774,-0.02189623,-0.031266302,0.07577988,-0.033498585,-0.001299564,-0.031778783,0.03816759,-0.02049285,-0.011482976,-0.04964842,0.035560556,0.00036187354,0.053832233,-0.0031351526,0.018789666,0.08229104,-0.1260214,1.8648663e-33,-0.0017728406,0.011758735,0.037552413,0.06536783,-0.037699148,-0.0007697859,-0.060157947,0.052971743,-0.13398607,-0.08616602,-0.061112545,0.002853559,0.009474454,0.04397435,-0.040639605,0.028999016,0.03386285,-0.006046558,-0.0028711145,0.03926514,-0.027190382,-0.0039086896,-0.015876912,-0.09398097,0.09464019,0.03466886,0.010344508,-0.051507737,-0.04079358,-0.02528442,-0.0013545838,-0.07433145,-0.071922876,0.060078256,0.03964125,-0.0028983653,0.058342934,-0.06421865,-0.020600487,-0.09974975,-0.07251368,-0.02328143,-0.049099196,-0.007976188,0.047355466,-0.047606643,-0.043277267,0.011712658,-0.0003684861,-0.012618689,0.058740336,-0.015020828,0.0071597793,0.019863218,-0.09942657,0.04870352,-0.028786335,0.028658507,0.08192915,0.060637645,0.05253404,0.030187946,-0.09614951,0.06131522,0.022717418,0.03248968,-0.08859461,-0.012591594,0.0323893,0.09953783,-0.07041911,-0.021896923,0.09606498,0.08441301,0.0007292474,-0.074151754,0.045164563,-0.016117632,0.027027197,0.076300904,0.0013206544,-0.036322117,0.00524825,0.018089088,-0.09631161,0.010965837,-0.011285163,-0.048638914,-0.08654063,-0.030905057,0.04063868,-0.003989014,-0.026934184,0.028855216,-0.084709264,-3.715221e-33,0.12055171,-0.06722446,0.031869765,-0.043288685,0.010098319,-0.017745022,0.01435885,0.007900007,-0.0022421626,-0.096196935,0.019041948,-0.05581025,0.047626738,0.0063931486,0.052345116,-0.012254368,-0.07216338,0.009960749,0.056727156,-0.030570576,-0.067047514,0.044181112,0.0063249813,0.061099567,-0.10344279,-0.063836,-0.015065183,0.094159,-0.030670576,0.04773907,-0.031915043,0.018836863,-0.067249075,-0.05061221,-0.029098198,0.052852537,-0.027170751,-0.0063014287,0.011507464,0.04151909,-0.029103572,0.028920544,-0.029343674,-0.032868713,0.008210587,0.08727754,-0.031316787,-0.0059607257,0.022435801,-0.041814238,0.05183488,0.016122285,0.010956352,0.05390454,0.05914315,-0.02552087,0.0052591893,0.00082941126,0.049018364,0.04393876,0.0120036965,-0.017457206,-0.020747976,0.04710138,0.07483575,-0.0039760643,-0.053193875,0.013110497,0.06510829,0.04686796,0.078177,-0.010065076,0.06004961,0.038530722,0.031537294,0.05030444,-0.10823833,-0.058368005,0.009032308,0.0057068784,-0.008879813,0.0062933313,0.01975802,0.008642346,0.0075862566,0.025290059,-0.018110275,0.04436706,-0.08603625,0.042173788,0.059805885,-0.12283034,-0.0066670133,0.112007,-0.055876028,-3.8792532e-08,0.055155728,-0.03157058,0.013167915,-0.13211103,-0.08534032,0.038546477,0.025441248,-0.014801842,0.045491707,0.0068027326,-0.0033559976,0.012841033,0.0061992286,0.07288401,-0.03188895,0.08397835,-0.049448457,0.072509,-0.06485474,-0.03093665,-0.05509284,0.049899094,-0.103944324,-0.0015903119,-0.0048841233,-0.00049546116,0.017634852,0.07985026,-0.02919951,-0.03905732,-0.08979693,0.03446589,-0.018642137,-0.05497867,0.018915262,0.016589912,-0.038303234,0.0031390474,-0.019569807,0.027115844,0.097485594,-0.062740184,-0.037832156,-0.03919634,0.032371875,-0.001570938,0.061149508,-0.022651631,-0.02469062,-0.019699872,0.051333968,0.096545465,-0.026342068,-0.11462733,-0.07226024,-0.069756955,-0.05856167,-0.049776107,-0.041680794,-0.068203084,0.0043333126,0.011032684,0.12646168,-0.014716752 +3.4.24.37,An 83 kDa cytoplasmic thiol-dependent metalloendopeptidase from Saccharomyces cerevisiae. In peptidase family M3 (thimet oligopeptidase family).,384,0.99999994,-0.025750218,-0.052333567,-0.078314975,0.011435623,0.0944587,0.017186848,0.028733607,0.07858029,0.032149877,-0.002929335,-0.0016378984,-0.03567546,-0.04679552,-0.033123866,-0.072583,-0.07509076,-0.04922692,0.0027480605,-0.032389313,-0.05858631,0.0838815,0.00062279153,0.057586126,-0.016875243,0.0006761223,-0.0061247516,0.005535285,-0.06145045,-0.023738679,-0.025259336,-0.011739016,-0.0731437,0.00942452,-0.024511838,0.06537262,0.011576124,0.027089525,0.01115392,-0.007765857,-0.0877134,0.09272204,0.019644946,-0.05051126,0.025093792,-0.062163692,0.00012698765,0.027105056,0.053588845,-0.032952692,0.03185857,0.048799522,-0.11407436,0.037233107,0.032243885,-0.010937883,0.07862002,0.012971005,0.007116816,0.05990135,0.04506976,0.034879215,0.012640058,0.009758183,0.008540376,-0.018166007,-0.0383911,0.03919772,0.066833384,-0.034016356,-0.009719258,0.029321583,0.037565574,-0.07249442,0.053605232,0.0454123,0.1379576,0.08882256,-0.07052378,6.49226e-05,-0.017917255,0.010831169,0.061115455,0.115934886,-0.02268976,0.03920395,-0.012424157,0.050392173,0.08573846,-0.010504055,-0.0019903213,0.03970902,0.010876061,0.031207656,-0.0015690053,-0.086406775,0.06136774,0.002702062,0.025953995,0.036949087,-0.023177687,0.047760222,0.065547794,0.025932401,-0.036010444,0.03473509,0.09539615,-0.0061055482,0.022633031,0.024077356,0.007528041,0.04559969,-0.038013123,0.03171812,0.017722083,0.018730028,-0.040985495,0.01217115,-0.039339878,-0.03346024,-0.03367386,-0.008229139,0.014820023,0.011095536,0.004866066,-0.043849528,0.025639085,-0.06159201,5.5056596e-33,0.02699921,0.008462892,0.027177224,-0.048247043,0.10169011,-0.024333693,-0.013853041,0.029972505,0.015991116,0.01758214,-0.10082775,-0.1401859,-0.04260947,-0.05386714,-0.02331218,-0.038906552,-0.03471777,0.018284546,0.035038497,0.011585465,-0.05973354,0.034571536,-0.06405044,-0.022810293,0.062965155,0.039904084,-0.030632604,0.009319949,0.06786717,-0.011945746,-0.035442404,-0.08607889,-0.059498485,-0.035317972,0.055076055,-0.057728693,0.06902234,-0.060163107,-0.05589126,-0.038010493,-0.08074148,0.02135991,-0.0118570225,-0.049362477,0.03972,-0.055723853,-0.063189484,0.02999888,-0.021285288,0.042933717,-0.03931554,-0.015288786,0.13355446,0.0012353802,-0.032477994,0.03325131,-0.0017065491,0.054768186,0.12470241,0.020753201,0.0067200544,0.051862102,-0.021507435,0.038493697,0.05542665,0.035102475,-0.07406625,-0.018560832,-0.052940372,0.08716307,-0.05539551,-0.012873233,0.024923999,-0.047565773,0.04406036,-0.04966488,-0.09355006,0.0004938956,-0.031916637,0.0032240474,0.03987138,-0.0120648,-0.0061430326,-0.05855842,-0.026947904,-0.008494714,0.022341592,0.058359552,-0.031969488,-0.006607263,0.04586006,0.019867878,-0.00090780377,0.016883314,-0.07973387,-4.730886e-33,0.1100834,0.040164214,0.11613348,-0.080360845,-0.0609987,0.04684671,-0.09713251,0.01957657,-0.035936702,-0.093890384,0.047696363,-0.054696847,0.017639913,-0.04754999,0.012687561,-0.041281283,-0.034013398,0.07099526,-0.018736113,-0.0026480102,-0.064527385,-0.024499282,-0.041702703,0.035486024,0.09175272,-0.0235314,-0.023859682,0.1429174,0.018991709,0.047555193,0.011352309,0.07551731,0.02621168,-0.11182717,-0.08010113,0.015177153,-0.0033413556,-0.04100249,0.07528312,0.087742835,1.0396308e-05,0.025993455,-0.03341555,0.060229074,-0.018351324,0.11320045,-0.07419218,0.04064774,0.046224266,-0.06653168,0.00081935414,-0.022805149,-0.055158734,0.038286764,0.059434794,0.0013117598,0.023720652,0.062141195,0.0020029738,-0.06740703,-0.016321562,-0.028465603,0.037628576,0.04187793,0.07301354,0.039606478,-0.0667939,0.08627817,0.015902016,0.03230881,0.005969287,0.04432962,-0.017969094,0.0083055105,0.01599052,-0.022469021,-0.021286137,-0.05797214,-0.015223598,0.009910947,0.0042187814,0.0014738317,0.042521704,-0.06210326,0.0015888748,-0.09037261,0.029364591,0.09980943,-0.044671,0.029273711,-0.040112283,-0.06441418,0.0040516537,0.110173844,0.032514304,-3.128224e-08,0.033475593,-0.021792619,0.002611751,-0.1061935,-0.02985268,-0.06452516,0.04321977,0.0048167882,0.007361374,0.019647522,0.016515348,0.003940311,0.00020559887,0.027231963,0.049454074,0.07481768,-0.061229154,-0.009085095,0.045233827,0.04128771,-0.0075861546,-0.0028667932,-0.05739635,0.050106592,0.018179355,-0.055007122,0.054605786,0.03829941,-0.024196139,0.036534462,-0.024900712,0.024326611,-0.042648967,0.02372167,0.010417304,0.05167954,-0.10133703,4.478167e-05,-0.03902217,-0.082768485,-0.059050106,-0.03912047,-0.05509575,-0.024111075,-0.062268857,-0.05205234,0.08965041,0.10182767,-0.038677752,-0.124686494,-0.04287713,-0.023445625,-0.03376058,-0.0707413,-0.047792703,0.0064895987,0.004847853,-0.015670558,-0.09734055,-0.066911645,0.01797837,-0.051756777,0.2103815,-0.05039343 +3.4.24.38,"A glycoprotein found in the periplasmic space of Chlamydomonas reinhardtii gametes in a 62 kDa inactive form; decreased to 60 kDa upon activation. A zinc enzyme, inhibited by phosphoramidon, but also thiol activated. Type example of peptidase family M11",384,1.0,-0.06417841,-0.025508607,-0.124413066,-0.05897134,-0.0068182307,0.049527276,-0.0030904897,0.015988998,-0.0043936516,0.026764642,0.08810403,0.0066982103,0.030871462,0.02653345,-0.04295479,-0.007586583,-0.060362846,-0.0365043,-0.033026595,-0.013259289,0.0720337,0.059346136,-0.030344684,0.02085149,-0.0025158797,-0.032677278,-0.03557011,0.009528035,0.03010613,-0.05501884,-0.051254656,-0.030127898,0.09861918,-0.008213594,0.0931681,0.044546757,-0.03846104,-0.08223306,0.022274517,0.0113481805,0.02199325,0.05685235,-0.04286189,-0.090240635,-0.036471337,0.004472069,0.05551844,0.061597735,0.030931288,-0.037409272,-0.028565658,-0.08660704,0.017623868,0.07304529,0.06589348,0.054174315,-0.08034286,0.0117337825,0.06861913,-0.03179219,0.040968947,-0.0038975296,0.0315512,0.0009936901,-0.06191966,-0.11575199,0.009784216,-0.0059396806,-0.004217154,0.019324858,0.03965686,0.045309298,-0.06965141,0.033092443,-0.020103343,0.06689471,-0.008299168,-0.11445998,-0.059853934,-0.0051268474,-0.003063871,-0.0047035846,0.046356462,0.09487463,0.0064046653,-0.029592458,0.060746472,0.047814067,0.0036024642,-0.04395646,0.053510744,-0.05160084,0.07062407,-0.0054571796,-0.12592293,0.00043826766,0.06550988,-0.0520805,0.03750939,-0.02164239,0.029674958,-0.01680756,0.0137592815,-0.042713564,-0.02324258,0.10496015,-0.036442257,0.063631915,0.01654226,0.05881348,-0.031843856,-0.023426857,-0.040586654,-0.0021285664,-0.030263344,-0.0124999555,0.063445926,-0.035713837,-0.011078571,-0.03769193,0.019190367,-0.022920448,0.040159937,0.0006096206,0.0017859048,0.10232361,-0.13372473,4.184701e-33,0.0016968226,-0.012746075,-0.008691331,-0.011116713,0.039050173,-0.023427408,-0.010245541,0.005483886,0.071415745,-0.13521045,-0.09726049,0.0329455,0.0017042732,0.01584246,-0.070895605,0.00094275235,-0.010798788,-0.019711863,0.022935724,0.0857229,0.03499468,0.07428975,-0.008793851,-0.08723564,0.0598222,0.01662822,0.034413077,-0.011352857,0.037857212,0.007848463,0.03196063,-0.090267956,-0.11807303,-0.04122201,0.10830209,0.010691131,-0.012828953,-0.056671992,-0.036429953,-0.00857132,-0.04473591,-0.03364179,-0.071292095,-0.039919805,0.058240626,-0.004019623,-0.060248956,0.06566659,-0.03726045,0.025798323,0.0044832844,0.034627937,0.038474042,-0.06820304,-0.096427836,0.015142385,0.01366931,-0.049044814,0.043800604,0.068916455,-0.01473314,0.056288376,-0.02115882,0.075274065,0.012379712,0.00030012112,-0.06229282,-0.024492098,-0.009485449,0.050552767,-0.048335746,-0.035866935,0.05055344,0.034988474,0.0163138,-0.117695205,-0.012450229,-0.021214943,-0.059478115,0.04109319,0.042252857,-0.030514164,0.03765494,0.0076451036,-0.048393168,-0.08601924,0.01164602,-0.03327767,-0.07819855,0.017209765,0.046286367,-0.0138923805,0.015756465,0.06683197,-0.061771903,-5.7967223e-33,0.10648394,-0.062258206,0.125628,-0.07534101,-0.009004589,0.09916444,0.00307157,0.037511673,-0.007466996,-0.08263483,0.024373587,0.046715394,-0.037764635,0.011904492,0.059316494,-0.024676656,-0.022329064,0.07446735,-0.04355407,0.00038759262,-0.10418519,-0.012089142,0.0007919557,0.057297293,0.02386467,-0.012221962,-0.010980654,0.03845045,-0.020198474,0.016728388,-0.006272599,-0.006414666,-0.051375154,-0.06300862,-0.07303032,0.029804677,-0.052754607,-0.048547745,0.051280536,-0.010310764,0.057837766,0.04825291,0.013595217,0.04989376,-0.0152779175,0.07096542,-0.0544209,0.037970774,-0.0068748407,-0.022313934,-0.011428219,-0.0061282497,0.037666608,0.057030022,0.11453778,-0.013012255,0.0037763158,0.056860927,0.030605346,0.031894516,-0.009588931,-0.10260615,-0.030697001,0.07966554,0.043038663,-0.002086481,-0.04760069,-0.006861838,0.039331276,0.024116652,0.051469076,0.05723298,0.0034395573,-0.021386506,-0.04721813,0.0750916,-0.08917992,-0.07368536,-0.020035645,-0.018882927,0.03310085,-0.0009234666,-0.011569375,0.015271613,0.020891959,-0.058165077,0.038028125,0.08874701,-0.05994647,0.014812943,0.032527883,-0.030510793,0.015764391,0.08857188,0.059117433,-3.6796763e-08,0.04410914,-0.02426288,0.01433537,-0.10487625,-0.024167184,-0.0037280938,-0.007112505,0.0019126515,0.0443126,-0.017599214,0.06216612,0.04984693,0.08119097,-0.00557121,-0.03488482,0.09387725,-0.055701014,-0.01857677,0.016486498,0.12299403,-0.08177215,0.017201632,-0.14962982,0.0804134,-0.05232748,-0.002459886,0.06773754,0.046701472,-0.06211101,-0.039235227,0.035755374,-0.0059605003,-0.034947347,-0.014781397,-0.03413893,-0.014385238,0.009714857,0.008312804,-0.050745673,-0.030992242,0.03161465,-0.0017771698,-0.0513953,-0.05563033,-0.010777288,-0.02856656,-0.016751777,0.014337312,-0.06563271,0.037837934,0.012576093,0.011449418,-0.033167712,-0.10921707,-0.09393737,-0.0013951964,-0.018003132,-0.028315824,-0.09731984,-0.0050834278,0.017917657,0.01311371,0.17738429,0.07085623 +3.4.24.39,"Proteolytic activity found in Penicillium roqueforti [4], P. caseicolum [4], Aspergillus sojae [3] and A. oryzae [1,5]. Optimum pH of 5 for digesting various proteins. Strong action on protamine and histones. Insensitive to phosphoramidon. About 20 kDa. A distinct Aspergillus sojae endopeptidase is larger and has a neutral pH optimum. Type example of peptidase family M35. Formerly included in EC 3.4.24.4",384,1.0,0.017269798,-0.057018477,-0.11278056,-0.065413825,0.115743436,0.03782569,-0.010377173,0.12743954,0.027875446,0.0258822,0.07837977,-0.0035740512,-0.011669601,0.13314968,-0.047644682,-0.025787028,0.02594675,-0.05135599,-0.05065044,-0.061818913,0.11158789,0.057191297,0.038488522,-0.008627041,-0.06406012,-0.048837177,0.022254134,-0.032875977,-0.035847913,-0.09826436,0.022174438,-0.038285095,0.03819197,-0.1076657,0.111341715,0.04479942,-0.062344708,-0.00030815208,0.09127611,0.027122919,0.051525563,0.010494989,-0.041763086,-0.08014931,-0.03449398,-0.02070559,-0.010991631,0.065026976,0.10062506,-0.023588462,-0.04174294,-0.056967955,-0.022036433,-0.023632454,-0.033541035,0.025962941,-0.025475306,-0.057506777,-0.0039060407,0.003329265,0.0048411777,-0.010677918,0.0031305163,-0.037626326,-0.014449926,-0.013989456,0.0139297275,-0.05636869,0.0023303884,0.013125888,-0.029506307,-0.02118155,0.013459384,0.12059204,0.0593325,0.08233073,-0.04999062,-0.045029905,-0.12555836,-0.059042376,0.0114355665,-0.02232423,0.029743461,0.025246639,0.0152886575,-0.04395264,0.03366476,0.006311912,0.10091877,0.008342002,0.034771867,-0.014098689,0.006849984,0.010627108,-0.022469006,-0.0023161757,-0.005791803,-0.039819654,0.00035473114,-0.043152645,0.00788676,-0.08222667,0.017840432,-0.06306501,0.06612728,0.035086136,0.0024497553,0.007074592,0.09167571,0.001127965,0.036778137,-0.05837419,0.013653552,-0.11120886,0.014168229,0.010772335,0.007967668,0.00021593495,-0.050430346,-0.014520676,0.056518387,0.012175991,0.003790122,0.0049628345,-0.019924752,0.10409287,-0.07268798,4.3443512e-33,-0.028534988,-0.002229599,0.0052410136,0.0034909497,-6.388357e-05,0.020669261,-0.046391875,0.010969676,0.08442491,-0.1297264,-0.071484566,-0.048595585,-0.0389114,-0.0020186983,-0.030837087,0.046697393,0.0010399703,0.0018116982,-0.007411354,0.06120775,0.030438216,0.0026566817,-0.057848543,-0.007510882,0.10383079,0.088357665,0.054974493,-0.03638173,0.032066718,-0.029308368,0.0395578,-0.07139086,-0.097184494,0.050632544,0.050773356,0.035474908,0.059941124,-0.035563402,-0.03095369,-0.025225168,-0.05635339,0.01702973,-0.027581776,-0.018069329,0.056762718,-0.091033615,-0.060609143,0.099551156,0.03026311,0.029141305,0.02700079,-0.027719112,0.068886,0.06380103,-0.068183444,-0.03958917,0.015623374,0.05091566,0.11434985,0.0608457,0.04321553,0.034997966,-0.038607687,-0.013300955,-0.0011561164,0.0211186,-0.08058279,0.011057776,0.037824802,0.025470698,-0.060209587,0.04700631,0.045045886,0.020871617,-0.0047193295,-0.089512095,-0.048473775,0.012958154,0.0069237966,0.041466746,0.060961425,0.026170904,0.023312576,0.02045853,-0.12540437,0.010975584,0.015634166,-0.009494544,-0.063617274,0.03777955,-0.015598226,-0.03212511,-0.0044738683,0.12364136,-0.03107626,-4.4736428e-33,0.08780655,-0.044814885,0.04949333,0.029341118,-0.027656196,0.048621155,0.019318309,0.08678634,-0.029622365,-0.0466618,0.03504449,-0.031613152,0.06647802,0.0049453485,-0.023112595,0.058381144,-0.023734454,0.083746545,0.046512526,-0.022409154,-0.10876098,0.08037477,0.021599328,0.036476485,0.09017635,0.033617083,-0.0013259038,-0.010079348,-0.082071304,0.036744356,0.0031005472,0.07640489,-0.016253509,-0.021361098,-0.08543899,0.06817388,-0.03695775,-0.030388158,0.027625084,0.06565165,-0.035507813,0.0016834363,0.056420483,0.028698172,-0.037316393,0.052898534,-0.023818456,0.029374722,0.04501524,-0.058615617,0.036251355,-0.0375357,-0.033871017,-0.030491652,0.008667792,-0.021904571,0.050375294,0.031057214,-0.034861054,-0.03024332,-0.015372455,-0.005455905,0.0028630546,0.053271987,0.005677282,0.031575218,-0.07383143,-0.02458976,0.09476483,0.0011505281,-0.0142372055,-0.008070671,0.039842438,-0.0033342182,-0.008810082,0.058123518,-0.0342581,-0.015311177,0.031974606,0.0028310565,-0.06896059,-0.06542327,0.017532544,-0.0427151,-0.021187315,-0.07007558,0.0057474314,0.051811714,-0.061590116,0.069590405,-0.018524196,-0.034881487,0.03224317,0.048924364,0.107942574,-4.215777e-08,0.10597015,-0.021351531,0.03899302,-0.047588807,-0.0073983045,-0.032759387,0.028844096,-0.059974447,0.1023826,-0.011728305,-0.030976757,-0.02349404,-0.01753178,0.049331143,0.009208194,0.06022157,-0.041800693,0.061852932,-0.014492061,0.016177606,-0.06715555,-0.011421543,-0.14499037,-0.02917523,0.012544341,-0.06341205,0.069486216,0.03131389,-0.044802606,-0.031186642,-0.044316553,-0.011858267,-0.093446866,-0.038808674,0.036918543,0.08310177,-0.029382495,0.02747574,-0.0219634,0.043220386,-0.016813956,-0.09601582,-0.10089432,-0.06387632,-0.038207665,-0.028595883,0.01631994,0.031296764,-0.046459246,-0.028092278,-0.00078913313,-0.041042052,0.01652231,-0.05265609,-0.081024155,0.03949846,0.008039657,-0.04487394,-0.089707,-0.058579996,0.02044244,0.020477822,0.15429914,0.01592881 +3.4.24.40,"A 50 kDa extracellular endopeptidase from Pseudomonas aeruginosa [1,2,6], Escherichia freundii [3], Serratia marcescens [4,5,6] and Erwinia chrysanthemi [7]. There is broad specificity in cleavage of the insulin B chain, with some species variations. The pH optimum for digesting various proteins is about 9 - 10. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.4",384,1.0,-0.023556411,-0.052945577,-0.13628624,-0.061960902,0.059997622,0.026810797,-0.009322151,0.09473881,0.0056293365,0.02796564,0.054607686,-0.026999298,-0.06615667,0.10897476,-0.06312361,-0.0014354656,-0.08113291,-0.08722268,-0.0051038996,-0.03145781,0.07480363,0.05023596,0.011697477,-0.02239438,-0.025403898,-0.039030682,0.067488484,-0.057336967,-0.03956496,-0.04972158,-0.0053214896,-0.08970185,0.08744303,-0.05743379,0.07019313,0.00777991,0.013995032,-0.08968742,0.053660206,-0.026102887,0.10167618,0.06970711,-0.04413362,0.0081889685,0.035695553,-0.009143384,0.0125982715,0.055591144,0.075549215,0.017255077,-0.076138936,-0.09631351,-0.013123298,0.05009653,0.028892893,0.080420986,-0.07162526,-0.012271207,0.039012413,0.006875847,0.0038164766,0.01316687,0.030742377,-0.007855259,0.024808748,-0.09744543,0.040363584,0.033614725,0.004795975,0.04494164,-0.059646964,-0.015573508,-0.028897632,0.09046116,0.042843316,0.058957826,-0.09261172,-0.045986276,-0.10199216,-0.028471103,-0.041472323,-0.026833318,0.10596495,0.042081624,0.04149552,-0.057989664,0.044421908,0.01233956,0.015485887,0.009706125,0.020187179,-0.07373423,-0.009175634,-0.021244053,0.004725589,0.011908934,-0.008568847,-0.0564569,0.0026452548,-0.06601184,-0.03971105,-0.026842812,0.016396703,-0.0721983,-0.009002087,0.030857084,-0.041203827,0.0810607,0.06582037,-0.03320062,0.07272287,0.018817112,0.0070552053,-0.06801956,0.027937474,0.042806618,0.06422205,-0.08114307,-0.019293565,0.0493653,-0.00097491156,-0.03130678,0.059528753,-0.008877508,-0.063389234,0.121525526,-0.06570291,2.614172e-33,0.005227458,-0.0106120445,-0.032926705,-0.0077870525,0.0006351812,0.019326542,-0.025335982,0.028471015,-0.0025445323,-0.06128016,-0.11438824,-0.044000737,0.008963537,-0.030437699,0.00034384956,0.020734569,-0.025493104,0.06580544,0.060243715,0.05787193,0.04747923,0.041543156,0.010242388,-0.11279235,0.11040052,0.091446154,0.03764452,0.0009003156,0.08554002,0.00027499814,0.036068305,-0.029267145,-0.050743602,0.01795127,0.03625724,-0.0026638038,0.0494428,-0.050255112,0.0067760595,0.019610155,0.06513523,0.0039895275,0.01896946,-0.00843329,0.07740623,-0.061976932,-0.008915918,0.04329062,0.023140362,0.024124881,-0.0147651965,-0.043884933,0.07929164,0.047557566,-0.06538773,-0.01805348,-0.028860424,0.008870168,0.068867356,0.023079399,0.020271,0.036813017,-0.05243756,0.0392613,-0.06018395,0.006343016,-0.10491688,0.03998436,-0.030124184,0.052756403,-0.07093361,-0.055596076,0.049810834,-0.018226238,0.02420481,-0.063109756,-0.07498519,0.021977425,0.0018176008,0.0063703265,0.07163297,0.019455042,0.00079873356,-0.012035427,-0.049644426,-0.014760431,-0.009001848,-0.0349895,-0.04113346,0.03238237,0.010680943,-0.019945819,-0.031433363,0.091180116,-0.045525517,-3.5358892e-33,0.1026255,-0.09679439,0.055095788,-0.024641253,-0.041745447,0.03186668,0.09673273,0.036433328,0.02818254,-0.05528755,0.05399409,-0.014420536,0.06823447,-0.027835157,0.020965982,0.028815437,-0.014103328,0.004062947,0.046077944,-0.09909602,-0.053476844,-0.0066236085,0.02833792,0.01574446,0.12260829,0.0668909,-0.03444807,0.089297004,-0.046570815,0.004874803,-0.027787926,0.013947001,0.0024830408,4.5720073e-05,-0.1028459,0.04015443,-0.10313645,-0.047360193,0.08171849,-0.023534102,0.029703252,0.021284776,0.0012859086,0.10105751,-0.003003147,-0.010352449,-0.047666643,0.05495716,0.056917593,-0.10698959,-0.027479421,-0.039532345,0.004311786,-0.011089016,-0.028204268,-0.030334214,0.014949574,0.04683352,-0.008257818,-0.033449117,-0.00039325637,-0.04272738,0.05679901,0.027732303,0.07565579,-0.015266738,-0.029718364,-0.010665309,0.027826006,0.028129477,0.012559036,-0.026986644,0.043567773,0.047186833,-0.036716368,0.060963478,-0.041647397,-0.052619744,0.04047472,-0.012912057,-0.06922927,-0.038312178,-0.0055884277,-0.047091056,0.051199563,-0.06989548,0.023480529,0.04625613,-0.05274912,0.019867523,-0.019003281,-0.036062326,0.04808045,-0.009677273,0.041332,-4.605212e-08,0.11281828,-0.05161498,0.019895703,-0.0434994,-0.02526735,-0.04331319,-0.06259975,-0.011790149,0.06897245,-0.07216731,0.0382661,0.015659507,-0.0094121,0.07378759,0.00024177117,0.00070140196,-0.088158086,0.0314097,-0.021235082,-0.0020435161,-0.13216726,0.00820932,-0.11904094,-0.0054640644,-0.008292205,-0.01669449,0.027088558,0.025196774,-0.012025181,-0.048236683,-0.029886004,-0.022551706,-0.030991951,0.11286645,-0.03577096,0.10105962,-0.022360425,0.05764656,-0.070020206,0.0072822697,0.074143894,-0.089795195,-0.060127534,-0.033645257,0.012166311,-0.024598908,-0.0026397163,0.068878405,-0.038787257,-0.016930023,0.05620008,-0.07764512,-0.015134575,-0.033664443,-0.064624295,-0.032069717,-0.07583373,-0.06765073,-0.029402077,0.021566983,-0.018106716,-0.0028606206,0.14491172,0.057902403 +3.4.24.41,From the venom of the western diamondback rattlesnake (Crotalus atrox). In peptidase family M12 (astacin family),384,0.99999994,-0.05092465,0.05931562,-0.09714533,0.044018727,-0.014119849,0.009033976,0.019159978,0.034888536,-0.01440867,-0.05398679,0.03272451,-0.10145409,0.06464111,0.021505099,-0.13558535,0.052555367,0.051629636,-0.039107047,0.054736245,-0.04363809,-0.0001821989,0.062884375,0.05110869,0.08431403,-0.057430573,0.018327508,-0.066450365,-0.0037152998,0.04621458,-0.10919015,-0.030279983,-0.04682766,0.031474993,-0.08775575,0.037835848,-0.025816163,-0.066733524,0.03628439,0.10296485,0.025061423,0.031005627,0.08295745,0.024197116,0.0030949672,-0.022428699,-0.017488306,-0.004918354,0.05504773,0.12773629,0.012905954,0.02282841,-0.017197514,-0.09881735,0.008889197,0.0767165,0.004280509,-0.074693404,-0.05798883,0.05603143,-0.00093427097,0.08636108,0.015036729,0.00030945754,0.018668,-0.058220398,-0.056568388,-0.02445842,-0.023346234,0.05954378,-0.054073,0.036718998,-0.043480325,-0.0017977776,0.046272304,-0.024159607,0.033351384,0.056694005,0.05115248,-0.085361086,0.0032556711,-0.040985424,-0.004553577,0.13441382,-0.044862673,0.09127843,0.068602785,0.043657385,0.03543416,-0.00791988,0.036311094,0.06454331,0.01873588,0.018230807,0.014573648,-0.057539187,-0.015871864,0.07876073,0.06330216,0.0053130784,0.07085564,0.07424699,-0.06246642,-0.029020343,0.012122478,0.013843695,0.017740544,-0.08103652,-0.027142635,0.042780496,-0.0244966,-0.039580412,-0.021367801,0.0018565293,-0.018362075,0.032301802,0.012174492,-0.0631923,0.031149337,0.111366935,-0.028488174,0.06530391,-0.014835838,-0.06835791,-0.038977683,0.02495853,0.038048387,-0.20910461,3.9678896e-33,0.007989566,0.026280794,0.052497696,0.035620462,-0.05343358,-0.083751604,-0.08092235,-0.08428854,-0.04654862,-0.04123001,-0.07208788,-0.08085892,0.00016025336,-0.014047716,-0.09114342,-0.0069971923,-0.12100147,-0.030467369,-0.01661747,-0.04363392,-0.055892,0.04582032,-0.062665686,-0.0039831526,-0.0020159795,0.015305172,-0.045543656,-0.004967391,0.034610868,0.028700281,0.010517845,-0.057091475,-0.0048534656,0.02114221,-0.051327407,-0.021641228,0.00988102,-0.114940114,-0.06364785,0.027803663,0.0811906,0.017954908,-0.053171325,-0.01658723,0.040049136,-0.06511106,-0.028364219,0.08334216,0.0320982,-0.027109914,-0.013966471,-0.06430776,0.09126536,0.03347867,-0.094223596,0.04078048,-0.0058134384,-0.05428058,0.021212224,0.043914456,0.083029084,0.0421224,0.013618312,0.016392823,0.027409218,0.018262327,-0.054207418,-0.05023667,0.022194019,-0.074246034,-0.028148934,0.025119953,0.06017493,-0.049507543,0.040921323,-0.018925954,0.003397375,0.03456868,-0.06353752,0.057459697,-0.04357726,0.0045421566,0.032570146,0.021409368,0.008448483,-0.011773275,0.04343334,-0.13582301,0.04513645,0.0867328,-0.03718459,-0.07434059,-0.023348575,-0.008988881,-0.024353275,-2.6137721e-33,0.027352162,0.025566788,0.13667662,0.0046697585,-0.016087366,0.047371946,0.045232836,0.06291528,0.04459085,-0.03889286,-0.021893818,0.03248979,0.02418205,-0.0068421606,0.078691706,0.03023533,0.09051289,0.03942457,-0.007864451,-0.029182162,-0.025317525,-0.003905184,-0.02603902,-0.032248206,0.009995586,0.051964425,0.040080067,-0.038032833,0.040089343,-0.014393204,-0.058310002,0.043461524,0.008604423,0.025244549,-0.1287982,0.0010602473,-0.052489143,0.0038556973,-0.010604358,-0.01062334,0.058425426,0.07528892,-0.039214164,0.07246154,0.003719036,0.07058655,0.030134577,0.10555581,-0.0042590024,-0.051832933,0.05619234,0.0001720186,0.061777815,0.027374173,0.042334333,-0.054852504,0.05805301,0.04224299,0.050987188,0.029618869,-0.0026788202,0.013753709,-0.10719308,0.04367272,0.05490058,0.103909805,-0.06841866,-0.02172373,-0.05778613,0.01697451,0.025276557,0.0063746353,-0.026722826,-0.019429175,0.02875511,0.08513845,-0.09749076,-0.08188189,-0.017924925,0.016049681,-0.05213055,0.0013786744,0.011733836,0.03704279,0.004768642,-0.050039884,-0.041407105,0.04412698,0.07446956,0.0003392434,-0.0067481166,-0.0027706923,-0.004037308,-0.013514808,0.067642696,-2.733606e-08,0.06564828,0.02476581,-0.0070330896,-0.06386892,0.009627816,0.08309423,0.05896809,-0.03127865,0.0107955625,0.018981803,-0.017045403,-0.040418185,0.06671129,-0.067596085,0.019352434,0.054155454,-0.035470422,0.016895475,0.022679396,-0.020803142,-0.025232233,0.024869842,0.042130835,0.023672206,-0.040715188,-0.05678967,0.036649052,0.04353602,0.022689965,-0.02619269,0.001705866,-0.013957353,-0.027560778,-0.088100806,-0.03987948,0.021587342,-0.043979164,-0.016423838,0.050549373,-0.019690806,0.048708178,-0.03479075,0.0013521507,-0.0379655,-0.07927753,0.023546435,-0.048641954,0.011185705,-0.008481764,-0.07243019,0.044265114,0.0027141029,-0.0012125369,-0.064217106,-0.09591126,-0.016886707,0.024949783,-0.053892065,-0.01947927,-0.06270836,-0.038483914,-0.021197418,0.12946428,0.030519942 +3.4.24.42,"A 24 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests type IV collagen, and exists as two forms, c and d. Phosphoramidon inhibits in the 0.1 mM range. In peptidase family M12 (astacin family). Hemorrhagic toxin-2 of C. ruber ruber has the same Mr and specificity and is a homologue [4,6].",384,0.9999999,-0.03215431,-0.046179175,-0.07210683,0.009113275,0.027048944,0.020106383,-0.028197877,0.08165362,-0.0151010165,0.011566435,0.0069222827,-0.047798406,-0.046025787,0.14234021,-0.15852296,-0.0017209315,-0.021465374,-0.008907284,0.04350324,-0.020030793,0.005743079,0.10526032,0.0031567425,0.059936907,-0.050694603,-0.043287292,-0.027636603,-0.07044657,-0.03145851,-0.07662245,0.0689706,-0.11077471,0.012046605,-0.069703,0.11044052,-0.059247416,-0.062914,0.031218022,0.092541516,0.03894722,0.030626163,0.036259625,-0.029056236,0.018398171,0.009521222,0.006309493,0.042089634,0.037981275,0.07161467,0.02855919,-0.011258477,-0.043486062,-0.106957175,-0.006465968,0.029189013,-0.00043840153,-0.088343136,-0.015916154,0.08496763,0.01856815,0.037621237,0.007433972,0.0495932,0.028920628,0.0079430975,-0.081876874,-0.015595147,-0.00320672,0.005990217,0.0064413375,0.035936214,-0.046591748,-0.0140482765,0.04961384,0.006626326,0.086113445,-0.034658164,0.037799425,-0.075967155,-0.020265196,-0.046037145,0.013557636,0.14845096,0.025994504,0.059624955,0.07301734,0.029731954,0.031086957,-0.031126192,0.06821439,0.06708541,-0.029146064,0.030666504,-0.021831596,-0.0022221676,-0.019072404,0.056483384,0.071760915,-0.057548627,0.004733792,-0.034319296,-0.05433915,-0.056865435,-0.040353127,0.036985647,0.010318081,-0.070858344,-0.023957243,0.110655054,-0.030706573,0.04212908,0.02246459,-0.02699214,-0.08802112,0.05220033,0.016893636,-0.004036744,-0.030713515,0.047452584,-0.0032630689,0.054141175,-0.073925436,-0.0076332446,-0.035936277,-0.00071202987,-0.0035403261,-0.124828234,4.003791e-33,-0.010384739,-0.0069025243,0.019133791,0.015960207,-0.041149396,-0.03544747,-0.11548455,0.016731033,-0.020477375,-0.02559889,-0.033161964,-0.06130348,0.0396132,0.00839494,-0.05256509,0.06053653,-0.07695079,0.026620792,0.004898765,-0.070107594,0.068938956,-0.020205352,-0.072908424,-0.02089692,0.0049788295,0.05702326,-0.07541588,0.0004394749,0.09144283,0.012712505,0.01546901,-0.10851059,0.020527272,0.045664433,-0.03239614,-0.052868083,0.018386107,-0.085780464,-0.0670605,-0.028777834,0.029882839,-0.0045652487,-0.09833403,0.012734233,0.08527553,-0.11567214,0.0019800402,0.048795253,-0.024302386,0.015864007,-0.021079702,-0.038398072,0.14130217,0.028771738,-0.024763986,-0.0015748355,-0.00088431954,-0.06470218,0.044040438,-0.015888574,0.079168715,0.033149984,-0.050037544,-0.04048285,0.014597107,-0.0023812228,-0.028764628,-0.015435411,0.042782076,-0.021926237,-0.059671972,0.02136546,0.022313658,-0.01778591,0.00052740425,-0.04477865,-0.052836783,0.07822825,-0.079725526,0.020729518,-0.0060317484,-0.036188528,0.040764257,-0.0002763269,0.036045436,0.04167073,0.06334719,-0.12050357,0.036330547,0.09683804,0.01746805,-0.07951793,-0.075660154,0.081701905,-0.023344813,-2.085723e-33,0.028419202,0.007428591,0.028146917,0.00015766975,-0.052840542,0.033097487,0.041335147,0.08398849,0.027948566,-0.07804125,0.03178637,-0.014040896,-0.0023217904,-0.010680396,0.040655047,0.02473148,0.081612684,0.0016358435,0.018334867,-0.017612256,-0.07694597,0.024698693,0.010819902,-0.039272986,0.09120393,0.072441086,-0.03407202,-0.0056087314,0.0033369348,0.08410579,0.023209412,0.061500847,0.037968837,-0.007988918,-0.11063673,0.0038337023,-0.101394184,-0.020969415,0.058156595,0.02885848,0.0813307,-0.024438318,-0.025928605,0.056591053,0.020092167,0.05136924,-0.0400717,0.13822404,0.041193426,-0.040613923,0.008921024,0.020693194,0.027500775,0.027601464,0.059407733,-0.065029494,0.0699386,0.043366417,-0.03310365,-0.01785223,-0.007323213,-0.010423431,-0.04530747,0.05750759,0.10984619,0.08657138,-0.08893785,0.033248655,-0.032386173,0.009099033,0.02623316,-0.019286655,0.060681663,0.00750529,0.016923018,0.023956573,0.0041369135,-0.008103744,0.045348868,0.014269126,-0.10333143,0.039037146,0.052074235,-0.054722324,0.08418218,-0.0272337,-0.059509225,0.04210663,0.00215536,0.022114389,0.033306748,-0.014537947,0.06513473,-0.0075721927,0.072908826,-4.3672628e-08,0.029180223,-0.048905257,-0.021912633,-0.10918191,-0.004696975,5.855934e-05,0.04677917,-0.017058011,0.012465062,0.053528916,0.045555286,-0.009721977,0.05136391,-0.018744534,0.05647986,0.03578151,-0.0023718018,-6.510805e-05,0.0061167004,-0.036719386,-0.043796454,-0.0028564907,-0.01666338,0.013056139,-0.024112362,-0.05640786,0.037109114,-0.004061141,-0.052867837,0.0046681305,0.047046,-0.030008841,-0.029444376,-0.017849803,-0.056992467,0.06941332,-0.037526604,0.032778997,0.03675938,0.025704214,0.011498644,-0.06815895,-0.03301388,-0.026645334,-0.059612617,-0.027110312,0.038458865,0.040624335,-0.01569895,-0.08948975,0.04280983,-0.0145152025,-0.026422122,-0.10090896,-0.054081697,-0.08117836,0.048755053,-0.02581695,-0.0648568,-0.057218734,0.019560987,-0.015902435,0.15377402,0.03588226 +3.4.24.43,A nonhemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that cleaves fibrinogen. In peptidase family M12 (astacin family),384,1.0,-0.023964887,-0.025694406,-0.085780956,0.038407058,0.056504052,0.031688504,0.008074303,0.06607556,-0.016041674,0.008545447,0.0069675394,-0.14001398,-0.030147811,0.0897103,-0.13017799,0.018423485,0.020517739,-0.029696107,0.08241152,-0.0050685895,0.04967,0.094300754,0.049158923,0.057618774,-0.05367593,0.04325283,-0.050480735,-0.08104379,-0.0043384135,-0.08228228,0.011231095,-0.08331781,0.0155052245,-0.08086037,0.0982746,0.0026377814,-0.065841906,0.023099475,0.083791666,0.0030577974,0.024398388,0.050012447,-0.023390366,0.019970804,0.0022999055,0.01155195,0.01671627,0.08075248,0.07785161,0.03223609,0.020999435,-0.055659518,-0.102032684,-0.040554624,0.08144609,0.0010518774,-0.049403884,-0.07112293,0.027187968,0.027517248,0.09815851,-0.0029099197,0.034076054,0.0022278808,-0.012250191,-0.06772326,-0.014489413,0.010695514,0.05198435,0.00054555875,-0.015059312,-0.02553906,-0.041309386,0.08169339,0.034113605,0.0768666,-0.0214424,0.024254067,-0.079431854,-0.04048778,-0.03783849,0.011603304,0.15430953,-0.013365723,0.09737706,0.05107774,0.036733855,0.05972564,-0.0057661524,0.05039992,0.035773024,-0.030158428,-0.004164279,4.526843e-05,0.008013492,-6.1180326e-05,0.038629897,0.010573085,-0.055982903,0.0066072023,-0.004011227,-0.04399717,-0.05178226,-0.05513794,0.009792247,0.014373373,-0.061487548,-0.02520974,0.0603878,-0.048703756,-0.012519712,-0.027649062,0.013170142,-0.08460625,0.085050166,0.026269596,-0.039087348,0.011062,0.06360656,0.07047052,0.06325135,-0.0036284602,-0.06407649,0.02473983,0.0021730459,0.026276058,-0.14677188,5.0867318e-33,-0.011187614,-0.0009531483,0.022040065,0.035307847,-0.01810322,-0.02369007,-0.08773648,-0.013101444,-0.03961716,-0.0030154584,-0.04480425,-0.06281024,0.027165353,-0.0011027241,-0.030040588,-0.0016870043,-0.10288613,0.031953234,0.024628265,-0.059436563,0.012648864,0.073637746,-0.04580143,-0.033221506,0.0064370087,0.060663808,-0.07712569,0.030104253,0.095507115,0.026777683,-0.0014826655,-0.078098506,0.02260193,-0.0026458884,-0.012160651,-0.04877543,0.021478137,-0.1033369,-0.09627493,-0.007440358,0.022192603,0.008460223,-0.13669083,-0.0056463187,0.0591567,-0.12721671,0.0061155646,0.08660508,-0.0008438173,-0.014993923,0.0008455415,-0.056555577,0.14456663,-0.0050670495,-0.08164776,0.034241024,-0.009627388,-0.023984378,0.0031953268,-0.01878208,0.069296144,0.06384809,-0.0505624,-0.06565895,-0.011440778,-0.013326196,0.001746714,-0.001638653,0.036865838,-0.03442849,-0.042213317,0.028405374,0.042809617,-0.0048072315,0.042175982,-0.020818757,-0.06281493,0.04630142,-0.057891373,0.0035769844,-0.0054941587,-0.003138388,0.051601846,-0.054898567,0.0327615,0.02752588,0.05113289,-0.109553136,0.012190153,0.11175025,-0.008882431,-0.06852419,-0.03127412,0.033801034,-0.039261263,-3.214807e-33,0.027351579,-0.019038742,0.029315904,-0.011890994,-0.031272136,0.051649306,-0.0071644885,0.033012293,0.010883572,-0.06239618,0.0063578174,-0.033345126,0.061217338,-0.047229968,0.03570768,0.011071283,0.07509474,-0.011012416,0.045618378,-0.03829058,-0.03301787,-0.028076597,0.037205722,-0.03028394,0.093741,0.08718464,-0.032375276,0.015477957,-0.009911117,0.035233542,0.005287804,0.032948017,0.051222052,-0.058004152,-0.14263646,0.029887209,-0.101329796,-0.007130779,0.05510695,-0.0046456866,0.058306795,0.007847371,-0.00031344141,0.0454602,0.017635057,0.02975166,-0.059419077,0.07047493,0.041248024,-0.10364661,-0.0036314547,0.003927275,0.016839825,0.022889612,0.037272364,-0.02822666,0.0035201055,0.076775156,0.034812365,-0.00025139475,-0.006305189,-0.015473616,-0.025943361,0.040956087,0.16390637,0.07005584,-0.07336202,0.022892497,0.000795856,0.029604597,0.018948996,-0.00096601126,-0.03916497,0.019533776,0.044290353,0.06721501,-0.031851403,-0.0589387,0.016758429,0.012201462,-0.06803576,0.012403642,0.022463651,-0.019811874,0.019429198,-0.09113834,-0.047445998,0.07991172,0.015731404,0.05409169,0.0098389825,-0.011627252,0.04862143,0.008008835,0.04515051,-3.261536e-08,0.07228785,-0.013056999,0.015849208,-0.06715549,0.003597737,-0.003733734,0.030173583,-0.030394357,0.008590992,0.009696815,0.035996243,-0.050691433,0.093386814,0.0030009171,0.04567769,0.03943901,-0.0015437056,0.0048058713,0.010215524,-0.05313513,-0.064869724,0.028283406,-0.033931874,0.008515011,-0.012778827,-0.06324429,0.048741147,-0.002034591,0.021468071,-0.009962263,0.0020109287,-0.038881943,-0.024182608,-0.04795132,-0.09269939,0.08392552,-0.05917934,0.009949427,0.009649966,0.055255402,0.068368666,-0.011082602,-0.027309956,-0.021168869,-0.043670036,-0.0015194981,0.04856696,0.021825507,-0.04132751,-0.103287384,0.06373159,-0.0023857842,-0.034207936,-0.061818663,-0.098683946,-0.02221806,0.025106937,-0.012857955,-0.0414799,-0.07808898,-0.056044437,-0.007935993,0.18493669,0.05514764 +3.4.24.44,"A 25.7 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests basement membrane components, including the triple helix of type IV collagen. Such action is believed to contribute to the hemorrhagic property by weakening capillary walls. In peptidase family M12 (astacin family)",384,1.0,-0.015752181,-0.02417524,-0.060568567,0.0007206833,0.03844053,0.00094832614,-0.027401695,0.08311023,-0.006572567,-0.006993222,-0.023799539,-0.06719595,-0.06309496,0.12967715,-0.14795694,-0.022965137,-0.013410856,-0.019489802,0.014958631,-0.046897665,0.012672705,0.09735297,0.028236452,0.043434363,-0.05811004,-0.00057983014,-0.03630904,-0.08786039,-0.004730594,-0.09718958,0.050032664,-0.12844002,-0.0043193437,-0.09177606,0.12311428,-0.030092232,-0.044125907,0.034521,0.05846143,0.01054704,0.06791396,0.025393508,-0.038413655,0.047338646,0.014960126,-0.008999871,0.038178883,0.02251379,0.06455209,0.037045576,0.040530372,-0.06169487,-0.09919903,0.005227038,0.036542103,0.04009764,-0.09528506,-0.031461306,0.088833176,0.016310139,0.05934282,0.03518893,0.017840674,0.014220267,0.013425387,-0.10302331,0.0035654004,0.014037416,-0.006535182,-0.009108479,0.034324687,-0.022875044,-0.023448173,0.035508167,-0.0057405178,0.08809163,-0.044430375,0.032739364,-0.060622305,0.011970496,-0.027043212,0.011103298,0.15787812,0.03694186,0.035431772,0.07897966,0.013971566,0.0061734216,-0.048818573,0.042254504,0.069677636,-0.05952324,0.045841817,0.0164209,-0.02749657,0.00014861576,0.051271997,0.033236384,-0.029013071,0.020133344,-0.028046869,-0.041791134,-0.006024712,-0.030093912,0.0475235,0.019818678,-0.067091,0.012933458,0.12707226,-0.032841116,0.017565645,-0.030655975,0.01376904,-0.044532035,0.07594624,0.01781349,-0.032920364,0.004313859,0.064269565,-0.00466205,0.034028895,-0.057235945,-0.03617077,-0.04335154,0.0064734835,0.001333986,-0.14412291,4.614157e-33,0.011248847,-0.0038756721,0.031249486,0.03062044,-0.06676503,-0.057545595,-0.12477875,0.0053095324,-0.043666538,0.027385633,-0.059116255,-0.07042901,0.012139275,0.010925322,-0.07565827,0.042313807,-0.110708825,0.019442614,0.0030455957,-0.016735474,0.03587111,0.011131214,-0.05738693,-0.02180879,0.03267802,0.036458794,-0.08672585,0.009078937,0.088617235,0.028123375,0.007215675,-0.07534836,0.033928838,0.051681146,-0.05492566,-0.009627897,0.04409111,-0.08113989,-0.08609793,-0.006728523,0.038355708,0.0047189356,-0.08220989,-0.0283404,0.079919256,-0.10597457,0.0007681862,0.044736773,-0.018051349,-0.022843275,-0.009002468,-0.031869795,0.12955311,0.032358907,-0.01590906,0.019837173,-0.010586104,-0.023260191,0.06449206,-0.016558524,0.07336902,0.01939263,-0.065739304,-0.013570659,0.032372907,0.030651253,-0.03542586,0.008818947,0.04940616,-0.028399872,-0.07172168,0.054109357,0.01685431,-0.030557573,0.004166939,-0.033638317,-0.041730497,0.07749389,-0.044143956,0.018872859,0.0059859403,-0.025390824,0.044016812,-0.009175897,0.048580967,0.034436353,0.08067368,-0.12955707,0.03138622,0.094287045,0.02292185,-0.07386411,-0.07700319,0.037361987,-0.014786457,-2.5759576e-33,0.056489084,-0.015671007,0.0086505,-0.020873994,-0.028606623,0.048303705,0.03351357,0.067803994,0.0056062206,-0.053104583,0.035125814,0.011643455,-0.0155827,-0.008485552,0.050856728,0.004573476,0.08514996,-0.04963993,0.015476902,-0.042567555,-0.07561558,0.029036922,0.01374668,-0.05591182,0.09698748,0.06790334,-0.07434495,-0.017850175,0.00522967,0.0597538,-0.02310932,0.0337091,0.041026454,-0.00019764448,-0.13458943,0.012190357,-0.09757311,-0.0013992015,0.059175625,-0.010344387,0.05283678,-0.013110604,-0.012829058,0.0513817,0.025742646,0.0634973,-0.040748812,0.093926184,0.044499893,-0.05995163,0.012931402,0.006199917,0.018371373,0.04763723,0.051742405,-0.037107777,0.093101956,0.057101898,-0.0066854376,-0.013289652,-0.020876296,0.022214882,-0.03621569,0.02762205,0.11665237,0.08210653,-0.11248012,0.01432311,-0.044502273,0.029947545,0.018119428,-0.012664303,0.05536747,0.043664437,0.05410765,0.022056663,-0.028889569,-0.048860613,0.0048562456,0.011792186,-0.104913585,0.048730426,0.04011665,-0.038870975,0.09833854,-0.046770178,-0.053426914,0.08101232,0.00760582,0.02742499,0.020050352,-0.01738771,0.015590008,0.015911626,0.064064756,-3.8478944e-08,0.0018749768,-0.025578488,-0.036137726,-0.10607166,-0.027452838,0.018315319,0.06796407,0.017805325,0.024719762,0.012633824,0.03473269,0.008459547,0.052225042,0.0029823808,0.028503994,0.059246846,0.0024401865,-0.03918643,0.0036380838,-0.09299693,-0.058404535,0.0047638547,-0.0028269629,0.032683976,-0.017179035,-0.078792095,-0.0026245713,0.014597465,-0.041562334,-0.006442176,0.028513359,-0.026065981,-0.028749082,-0.034029856,-0.037901666,0.09134177,-0.010647776,0.0052186837,0.038814634,0.020570682,0.04255084,-0.08233148,-0.029280247,-0.04506952,-0.049172617,-0.006441351,0.04776391,0.06396395,-0.03334564,-0.072545424,0.011614906,-0.03299609,-0.043750275,-0.074020974,-0.048347834,-0.067998335,0.028853506,-0.029334921,-0.032702986,-0.036086,-0.0068460065,-0.014482623,0.16662687,0.0048110774 +3.4.24.45,"A 64 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests the gamma chain of fibrinogen. Immunologically distinct from EC 3.4.24.1, atrolysin A.",384,1.0,-0.029381618,-0.0243933,-0.056990642,0.020307045,0.059731286,0.040058684,0.046795428,0.05499978,-0.029746417,0.011328386,-0.018959152,-0.105555296,-0.06989409,0.098438896,-0.126218,0.0043430035,0.023633951,-0.032449946,0.07696679,-0.056940474,-0.00043323828,0.08062197,0.029964475,0.037873324,-0.06317936,-0.0027188002,-0.046019997,-0.07625399,-0.028898995,-0.060249638,0.0057093664,-0.11379381,-0.03140627,-0.05200837,0.060579013,-0.015629278,-0.048627876,-0.008928935,0.013823115,-0.007388776,0.06648789,0.04359928,-0.010315113,0.035072356,-0.031134885,0.016997322,0.013189828,0.041131068,0.044696525,0.02918113,0.066247925,-0.049971975,-0.07044175,-0.0031474007,0.036970906,-0.028458001,-0.07860109,-0.084637865,0.056256145,0.032440715,0.016931234,0.0032284488,0.03491969,0.020718211,0.049645383,-0.08362295,0.009252327,0.00976463,0.0007327519,-0.006580099,0.0005371546,-0.011106895,-0.050741676,0.07126482,0.03906776,0.074047364,-0.015571436,0.038677834,-0.017909741,-0.04845566,-0.060570274,0.021276046,0.14684653,0.03286721,0.10547882,0.0245679,0.0038173008,0.08079571,-0.058963597,0.0935931,0.084195994,-0.027443066,0.03638382,-0.005101658,0.048585467,0.036055557,0.05110046,0.018997625,-0.01365586,0.0047499905,-0.03983928,-0.01518292,-0.042883467,-0.044426683,0.025179572,0.028612943,-0.06281509,-0.011408201,0.07260788,-0.046216946,0.012909022,-0.049946435,0.058740724,-0.064409465,0.1067069,0.023105888,-0.038309086,0.01335256,0.084258504,0.024226725,0.06393501,-0.036020882,-0.041314624,0.027358549,0.049269803,0.033171188,-0.10484998,3.3903678e-33,0.028115554,-0.02705878,0.029642716,0.033921864,-0.04280385,0.026079977,-0.09042929,0.041067164,-0.025177728,0.053675603,-0.04729468,-0.111321665,0.036783047,-0.011152931,-0.07725497,0.0041092522,-0.0814848,0.028164271,0.0059971823,-0.0635547,0.03172318,0.026091442,-0.023684459,-0.019421386,0.026034063,0.0684547,-0.13233393,0.044722214,0.061069835,0.036238965,0.013458345,-0.1266691,0.027825192,0.06950311,-0.047294036,-0.028707724,0.027377954,-0.033773106,-0.07140537,-0.0010951434,0.06853506,0.001211594,-0.15646487,-0.040950954,0.050063383,-0.10507646,0.007956356,0.039788764,0.0028568013,0.0058733043,-0.011935199,-0.05519488,0.15630394,-0.04434704,-0.011981632,0.05874025,-0.0033806653,-0.018042777,0.0028548464,-0.0506173,0.0312801,0.09551149,-0.04949982,-0.03919263,0.014284118,-0.0011991806,0.0067659304,-0.05061936,0.0026720313,-0.058857873,-0.04504605,0.0653339,0.07193304,-0.038731486,0.032931883,-0.01897824,-0.110084996,0.01623095,-0.080363765,0.028470395,-0.039246317,-0.040008605,0.03515143,-0.009240108,0.050691072,0.046797004,0.07288921,-0.09682545,0.050962735,0.078135595,0.033850458,-0.065998636,-0.049404416,0.049521618,-0.00020862864,-1.556165e-33,-0.002204486,-0.0036349301,0.019182539,-0.008713458,-0.023390194,0.05556998,0.017123593,0.07203001,-0.005747002,-0.034939975,0.06567665,0.0003708571,-0.022797864,-0.020474853,0.053940874,0.03692637,0.02931851,0.0027846913,0.026107363,-0.044487275,-0.08657745,-0.031132326,0.053247627,0.004072702,0.108317174,0.09043293,-0.01072521,0.03139055,0.036275256,0.036438696,-0.013686051,0.03499407,0.05637439,-0.04965755,-0.12050462,-0.037274893,-0.057636086,0.043871183,0.0911293,0.0057638558,0.084528156,0.02807742,-0.022172581,0.038314797,0.031067396,0.10806778,-0.033625815,0.09469549,0.048252814,-0.070307605,-0.01903673,0.0138173625,0.03866441,0.0066726385,0.0069378414,-0.012601834,0.029235069,0.09151973,-0.00045198252,-0.025873378,-0.03839485,-0.03292075,-0.004886406,0.04017085,0.15100397,0.08700773,-0.04816118,0.054117993,-0.028116452,-0.006593587,0.02835943,-0.045002438,-0.02462627,0.002080731,0.08256982,0.028521316,-0.0006641728,-0.022504594,0.038054243,-0.015202119,-0.053471867,0.031067535,0.02105103,-0.06684552,0.069490895,-0.052709322,-0.061794326,0.08356793,0.016242607,-0.002744549,-0.020711813,0.011675482,-0.0056271465,-0.0351564,0.048470203,-3.6687666e-08,0.06795373,-0.03444238,-0.009036944,-0.081904694,0.015471454,0.020864151,0.040505968,0.015499712,0.021245861,0.03826667,0.040984213,-0.022045152,0.06861012,-0.022731125,0.047275193,-0.01824496,-0.04216224,-0.0425095,-0.012933364,-0.06957732,-0.040832732,0.018204011,-0.026157519,0.008912907,-0.042290315,-0.05911095,0.022621997,-0.0024843966,0.0145376,-0.047231056,-0.01803169,-0.0030860486,-0.040304758,-0.012821462,-0.11393477,0.042156167,-0.043943256,0.0015028929,0.04126874,0.027797788,0.0065399827,-0.03253836,-0.042717397,-0.051699534,-0.06969994,0.0043560965,0.035676625,0.02714201,-0.016849192,-0.092524104,0.01783244,-0.012824019,-0.026774744,-0.07567164,-0.065751344,-0.05802197,0.028895015,-0.030011412,-0.048078634,-0.053249914,-0.036978632,-0.033531465,0.12973236,0.01390081 +3.4.24.46,From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate alpha1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family),384,0.99999994,-0.015608096,-0.015607637,-0.061240517,-0.00495015,-0.002644085,0.036835637,-0.0032657892,-0.016648524,-0.03631538,-0.04412723,0.013412212,-0.07206071,0.04476334,0.06562493,-0.10901327,0.051374152,0.006147941,-0.0079118265,0.031943206,-0.06581234,-0.03515922,0.03733263,0.02689459,0.060489703,-0.023469094,0.0048407037,-0.057059646,-0.027672857,0.037973266,-0.09862454,-0.045182046,-0.10414544,0.08091765,-0.075182706,0.06897118,-0.041580338,-0.073606424,0.00696013,0.04253573,0.032927845,0.047992628,0.07245371,-0.035875194,-0.028354999,-0.034901842,-0.04678004,-0.0029717807,0.0705509,0.11232847,-0.011077134,0.035641417,-0.041017108,-0.10536117,0.011121167,0.06020853,0.017726416,-0.05923922,0.030590696,0.085762694,0.009140842,0.09145249,0.04181379,0.046917252,0.015585114,-0.0058013056,-0.07453218,-0.0128563605,0.024397388,0.038417432,-0.023335412,0.038203333,-0.06790333,-0.053538613,0.034810364,-0.00694115,0.020746514,-0.017098341,0.010147619,-0.06722267,-0.055086777,-0.033894923,-0.022060119,0.13704437,-0.006449424,0.04235157,0.05780419,0.00512173,0.015167551,0.03136768,0.021565003,0.12419189,-0.027832743,0.04752881,-0.0015328128,-0.008121759,0.009780897,0.041242268,0.03944495,-0.04000546,0.035212796,0.037041243,-0.035371374,-0.06490734,-0.022029579,-0.0083895605,-0.0070518516,-0.06015189,-0.00891527,-0.003315474,0.014836173,-0.01468251,-0.050759893,0.022165336,-0.009406514,0.020279799,0.026424281,-0.013304451,0.013072555,0.07075639,-0.025721796,0.08913388,-0.015442943,0.01540689,0.018232664,0.01058336,0.061533723,-0.18030868,4.2339198e-33,0.014563576,0.035307206,0.014525999,0.031302903,-0.05787988,-0.07406976,-0.09712379,-0.04354136,-0.037360393,-0.043124653,-0.051739275,-0.010053589,0.051599734,-0.045765147,-0.02174859,0.022492616,-0.026133474,-0.014938921,0.008417912,-0.022663932,0.003693036,0.027236419,-0.07815855,0.015002568,0.008870449,-0.012118041,-0.05205934,0.055598035,0.080494,-0.001060784,-0.048905347,-0.07703271,-0.06442242,0.046624284,-0.038473163,-0.06283906,0.03143779,-0.0953239,-0.060536977,-0.008537595,0.009718834,0.017392261,-0.09684983,-0.104881175,0.07782455,-0.074140824,-0.021477697,0.09093111,-0.01010201,-0.027351012,-0.020701481,-0.016345108,0.12405734,0.02384625,-0.07310935,0.05378123,0.00015516714,-0.060904086,0.035814304,0.010819237,0.048968673,-0.0046470254,0.03539077,0.01641101,0.007217652,0.03014518,-0.07012698,-0.0331814,0.015362788,-0.019291874,-0.11430807,0.022842808,0.06343806,-0.054097667,0.054929376,-0.100827545,-0.021892268,0.003594049,-0.08195579,0.077458195,-0.036555156,-0.020408198,0.040062953,-0.004926898,0.022856854,-0.042570177,0.052451927,-0.087274514,0.039956316,0.079252705,0.018526306,-0.052292917,-0.039570842,0.08394879,-0.011793308,-3.553154e-33,0.060364474,-0.026247118,0.17408237,-0.047218688,-0.00989289,0.068202294,0.053885892,0.04241951,0.07241234,-0.07502812,-0.008368018,0.003957831,-0.0020643028,-0.029009068,0.038842723,0.014413995,0.04151135,0.06098747,-0.025175232,0.00062661106,-0.042373378,-0.030223167,-0.030448565,0.04784817,-0.0041684923,0.044340335,-0.0035361282,0.057385206,0.065706484,0.034653194,-0.026174884,0.06897244,-0.015413461,0.029289516,-0.121841416,0.00012192974,0.011272021,0.034102958,-0.0029013248,-0.0030533464,0.0716622,0.0829149,-0.07211517,0.044474553,0.02476358,0.09502962,0.019610982,0.107405916,-0.044821173,-0.09297385,0.050323617,-0.0078038475,0.020050528,0.046552345,0.04965161,-0.041918606,0.08312619,0.110833816,0.030929638,0.037139673,-0.00442761,-0.050033405,-0.050163537,0.058922853,0.06097801,0.07640616,-0.042022545,0.061503943,-0.010265823,0.03483172,0.015259115,0.00970223,-0.0031380518,0.00883469,0.05411028,0.057667896,-0.056233853,-0.12605155,0.020210018,-0.059432592,-0.07448328,0.020357545,0.00461958,-0.015657768,0.023954097,-0.0242723,-0.046858653,0.07134206,0.020251922,0.03237578,0.018281518,-0.077165574,0.017967861,0.0533999,0.061070815,-3.467557e-08,0.07762543,-0.0063476698,0.008355838,-0.07782094,-0.005571115,0.04360751,-0.00074827025,-0.026013277,0.039181765,-0.025023056,-0.0006008502,-0.04313285,0.05179794,-0.038817763,-0.015464648,0.06678189,-0.0655936,0.04162436,-0.006915052,0.007202033,0.0017786724,0.021180559,-0.027419616,0.025426941,-0.048797708,-0.08044737,0.018959908,0.07071602,-0.0059072515,-0.038501635,-0.014845031,-0.03405842,0.017502727,-0.05600674,-0.040852413,0.020426992,0.015170361,-0.016141754,0.045317244,-0.01023086,0.056209546,-0.07383097,-0.03648056,-0.08580996,-0.06391217,-0.010013526,-0.007476831,0.006862801,0.010780867,-0.050566442,0.064015634,0.051183883,-0.025888054,-0.13324966,-0.04897814,0.01287314,0.0070222174,-0.06201806,-0.040274575,-0.041695505,-0.0040664263,-0.08069831,0.14739926,-0.036604613 +3.4.24.47,"A 56 kDa hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus) that cleaves basement membrane, hide powder and fibrinogen.",384,0.99999994,-0.00052550767,0.01105275,-0.03656122,0.01767902,0.055791132,0.0056641893,0.038051426,0.056625243,-0.0034898391,0.033459745,-0.041237082,-0.12146333,-0.08624523,0.10101175,-0.09574002,-0.010310953,0.007696041,-0.020764513,0.049008314,-0.010803146,0.0478561,0.120285735,0.0014663256,0.034368742,-0.040525485,0.05184549,-0.033543993,-0.07232018,-0.0014983959,-0.07124957,0.025008997,-0.115358755,-0.018193468,-0.12783983,0.089501545,-0.0140987355,-0.07450085,0.0049991705,0.05467716,0.02512782,0.03319076,0.06697249,-0.057627425,0.04246839,-0.07388383,0.00972645,0.016354838,0.032851797,0.042595424,0.01954916,0.0410042,-0.059061967,-0.118715025,0.015421453,0.049253203,-0.012107569,-0.03889864,-0.047992714,0.06444647,0.040369254,0.04726012,0.027356459,0.028206112,0.032083545,0.0404506,-0.112635,0.003727265,0.0154405,0.04257274,-0.007315513,0.018198382,-0.014624468,-0.032751445,0.02945056,0.016729256,0.08192339,-0.01343922,0.010059789,0.011282819,-0.012961041,-0.04306343,0.04998666,0.14808594,0.035633124,0.081471816,0.077413104,0.01637171,0.044387646,-0.037163526,0.024962874,0.097695015,-0.03969383,-0.02705102,0.016173793,0.0146605875,0.016743394,0.0044361083,0.057546712,-0.07147792,0.017513799,-0.058860052,-0.055687007,-0.022456383,-0.06403791,0.0059966925,0.008658529,-0.03885871,0.03151986,0.057359416,-0.039450433,-0.020785967,-0.0047569666,0.035896897,-0.02791886,0.12958123,-0.0024469935,0.008402471,0.00013514044,0.028190808,0.053114466,0.065701514,-0.060220554,-0.011178572,-0.016595496,0.033839263,0.013259603,-0.0918174,5.445996e-33,0.03941838,-0.03752894,0.010557527,0.016436644,-0.04127526,-0.06543361,-0.096581094,-0.0046951734,-0.05858739,0.08301045,-0.03799278,-0.08056475,0.010656559,0.028788667,-0.04102979,0.0030496502,-0.07229418,0.026020583,0.018808004,-0.05377109,0.039959244,0.04002917,-0.04538664,0.010892284,0.013877508,0.04757411,-0.103533514,0.0053238375,0.05391584,0.05013998,0.023830025,-0.10728105,0.033371788,0.036958836,-0.047381055,-0.022176083,0.021239636,-0.095181644,-0.10272672,-0.055159684,0.04235413,0.033040058,-0.103700705,0.008600029,0.062392257,-0.100356035,-0.006254972,0.07236422,-0.012415166,-0.012534697,-0.0005188591,-0.017470334,0.15155062,-0.011279749,-0.061740007,0.02870804,0.016935585,-0.069441944,0.03948487,-0.026383018,0.017343264,0.092755534,-0.045885544,-0.015092553,0.06493643,-0.049985196,0.018231925,-0.032982245,0.056424297,-0.077111244,-0.064872324,0.022546513,0.020789148,-0.045549475,-0.022507228,-0.04830836,-0.05845129,0.025784882,-0.071508765,0.0011149398,0.053026773,-0.06384317,0.03854393,-0.036446575,0.08707842,0.014220975,0.033192936,-0.11512337,0.022232458,0.09740912,0.018435283,-0.046275195,-0.046872202,0.012234876,-0.038540825,-3.126917e-33,0.034505025,-0.003067687,-0.0037145242,0.0065256096,-0.042165432,0.08490629,-0.034779895,0.07584899,-0.019020624,-0.04852638,0.033063736,0.002984396,0.06381504,-0.0075314036,0.020963622,0.024305042,0.0629965,-0.025270991,0.049407538,-0.07884956,-0.074640386,-0.026425235,-0.014185227,-0.049259786,0.13449909,0.07315535,-0.046053767,0.012634536,-0.016620085,0.009918038,0.0065199034,0.014710875,0.05680827,-0.018383669,-0.115726836,-0.032082304,-0.044522252,-0.029453434,0.06822401,-0.031571604,0.04831859,-0.0055456627,0.041552052,0.030128041,-0.025975296,0.029386122,-0.05175566,0.06868527,0.051836263,-0.04802589,0.007594413,0.038946807,-0.017073605,0.009811643,0.027561659,-0.019091789,0.037452444,0.040692315,0.00096577464,0.0056546545,0.02059497,0.011850369,-0.05147501,0.029386386,0.14614849,0.084844455,-0.068128,0.065292194,-0.028394371,-0.015845368,0.04531914,0.024782198,0.0029445055,-0.0015789715,0.03381124,0.02346812,0.019131565,-0.058317266,0.03752006,0.050142925,-0.03539565,0.018154029,0.037025735,-0.051018924,0.10516317,-0.06519586,-0.058691435,0.09891695,-0.004749115,0.030134683,0.0033573764,-0.0383427,0.031237636,0.025723344,0.07231557,-3.4676543e-08,0.00808819,-0.020522563,-0.027732102,-0.09193067,-0.035286896,0.024814658,0.0829278,-0.015915416,-0.008613549,0.009830622,0.06041814,-0.013782267,0.048203606,0.039605215,0.051451802,-0.007538486,-0.031221395,-0.028750155,-0.012592709,-0.10512189,-0.017477304,-0.007693703,0.0058074887,0.038201775,-0.009177166,-0.06847831,0.023421453,-0.008692017,0.007509461,0.018573368,-0.01122902,-0.011261098,-0.06575379,-0.016258338,-0.063138105,0.106506236,-0.04127738,0.008670016,0.0048694303,0.057296414,0.049335893,-0.07379124,-0.0161514,-0.03594892,-0.05689678,-0.014264012,0.040556878,0.039133806,-0.059829902,-0.09768532,0.070258126,-0.008224459,-0.013649517,-0.049902312,-0.06915998,-0.02539731,0.022430392,-0.024574943,-0.04198957,-0.06991768,-0.037542023,0.0013795434,0.15508658,0.012491087 +3.4.24.48,A 25 kDa hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen. In peptidase family M12 (astacin family),384,1.0,-0.06635011,-0.04181726,-0.09179361,0.03238771,0.037077647,0.032322913,0.030920768,0.0730605,0.0006979182,0.022273127,-0.0019412015,-0.108123295,-0.047185637,0.1143251,-0.09850374,0.020391325,-0.00492973,-0.02759371,0.043150432,-0.03934775,0.033165876,0.116183706,0.03469358,0.056305688,-0.066535994,0.018673927,-0.008524991,-0.09898481,-0.020568244,-0.085112676,0.039553393,-0.10281845,0.008661388,-0.10178514,0.10196664,-0.03942879,-0.0778153,0.005752862,0.09664372,0.02428874,0.044047847,0.038217045,-0.020334084,0.0014029967,-0.0038441096,0.011907853,0.053545486,0.09912054,0.10163858,0.034260936,0.018488042,-0.040594842,-0.134967,0.00023298946,0.07727447,-0.022240162,-0.06624982,-0.06245491,0.03985203,0.0338855,0.06828146,0.0145994015,0.029570771,0.007499731,-0.025201082,-0.08991264,0.0031571523,0.023238663,0.03920634,0.019500736,-0.004394779,-0.038960967,-0.027637152,0.08931021,0.020948283,0.053573105,-0.0099674035,0.041528,-0.07937441,-0.044264186,-0.059152402,2.0368449e-05,0.16131915,0.031002747,0.10234613,0.062000453,0.053872857,0.058377333,-0.0054926313,0.045679152,0.04539922,-0.005523212,-0.01561198,0.0046658027,0.0067135612,0.0075584026,0.010614036,0.06635001,-0.05266257,0.0053280406,-0.022460617,-0.03650414,-0.048142083,-0.07213728,-0.010014573,0.0034227062,-0.065110534,-0.0014409826,0.08336663,-0.02764877,0.005247789,0.0021442983,-0.0005741526,-0.082440116,0.07927684,0.019807197,-0.01172854,-5.963467e-05,0.044054925,0.05968062,0.082585044,-0.014319389,-0.03187268,0.012096831,0.010961097,0.012957458,-0.13579863,5.603975e-33,-0.021149097,-0.01603002,0.039240688,0.030057566,-0.037308734,-0.033753257,-0.09786958,-0.0018172428,-0.0217422,0.0004945221,-0.028052745,-0.06642586,0.04726017,-0.0028048311,-0.04573685,-0.0018713933,-0.095460735,0.031087974,0.0006393939,-0.056102756,0.04021879,0.0753234,-0.04964195,-0.016019383,-0.0072665564,0.070123486,-0.07575503,0.014721973,0.09974338,0.023842596,-0.011833976,-0.09718098,0.028030325,-0.0039092544,-0.02759358,-0.069728784,0.01960705,-0.10373536,-0.07385877,-0.0074760597,0.02823105,0.0063920133,-0.12862758,0.033263158,0.053740967,-0.09751686,0.009691335,0.064997256,0.012365052,0.013947161,-0.023684463,-0.036252722,0.16454488,0.010049816,-0.054507513,0.015952686,-0.010635372,-0.033993553,0.025925001,-0.024499157,0.059124436,0.07762345,-0.036430538,-0.03482467,0.024481336,-0.018911704,0.009183624,0.010396519,0.05340027,-0.025509,-0.054856487,0.040888045,0.05618771,-0.04010691,0.03917077,-0.047478355,-0.059068315,0.03667326,-0.07463728,0.006338306,-0.012952293,-0.026349323,0.05996246,-0.036949843,0.028731208,0.03490678,0.048782513,-0.098179325,0.016252588,0.08973944,-0.014365201,-0.061710328,-0.037625402,0.0096703535,-0.039254654,-3.577523e-33,0.03905599,-0.0057916525,0.01790277,0.01421357,-0.044202447,0.018907266,0.0061885957,0.052851792,0.0063150884,-0.05521492,0.025273915,-0.014935153,0.048019674,-0.02550902,0.02491067,0.031791247,0.039024863,0.0082916785,0.028935336,-0.0562494,-0.06632892,-0.01907917,0.041762166,-0.025697801,0.106535755,0.07997136,-0.029339073,0.0056709624,0.009642662,0.032609634,0.023278885,-0.0005185719,0.02826591,-0.047897432,-0.13310973,0.013591627,-0.06943158,-0.041472934,0.045326475,-0.021614946,0.07818173,0.012178295,0.015640521,0.060573284,-0.005684811,0.015816811,-0.071137145,0.11747,0.033718,-0.09493158,-0.010567636,0.009443947,-0.013147258,0.02477352,0.027902253,-0.047288287,0.026927684,0.059776645,0.018583009,0.020483343,-0.01708585,-0.04086747,-0.029124675,0.038530815,0.14433844,0.03601544,-0.053276755,0.048141744,0.007467377,0.05531105,0.055107735,0.015465971,-0.024663534,0.003644764,0.04879092,0.060355812,0.026454132,-0.050811075,0.009371543,0.015469479,-0.07124147,-0.0099434,0.013536928,-0.032495767,0.033725623,-0.08146837,-0.037983652,0.06373728,0.021203002,0.020302853,0.0114354,-0.054234117,0.083763994,0.03856931,0.02178588,-3.31497e-08,0.05128944,-0.035458315,-0.0017551667,-0.06651255,0.013026109,0.004410811,0.011627798,-0.0051913923,-0.009447976,0.034024697,0.058003105,-0.047580093,0.07795216,0.011650094,0.046907313,0.01927592,0.0006293519,0.021666197,0.016451245,-0.070934504,-0.04052007,0.027176784,-0.033402268,0.013089272,-0.021928597,-0.04652985,0.035076026,-0.006851814,-0.014630604,-0.01631515,0.023413999,-0.04318792,-0.03464362,-0.034941446,-0.062391635,0.054264326,-0.074443825,0.039699927,0.030069305,0.061796926,0.0497991,-0.054719932,-0.03376766,-0.012108425,-0.06848406,-0.025743313,0.008244556,-0.009357436,-0.05427811,-0.09980037,0.07070267,0.0067286105,-0.03482492,-0.07786173,-0.090430245,-0.034670807,0.013382407,-0.012201443,-0.04544119,-0.07868457,-0.046422265,0.009825987,0.15779488,0.06151752 +3.4.24.49,Caseinolytic endopeptidase of jararaca snake (Bothrops jararaca) venom; 48 kDa. In peptidase family M12,384,1.0,0.059168164,0.006543933,-0.08568925,-0.011041461,-0.0058635566,0.036190636,-0.02227423,0.054364692,-0.023843966,0.06431304,0.07035603,-0.079175405,-0.01832785,0.10635108,-0.01476125,-0.010536059,-0.020111887,0.0122275185,0.009752734,-0.010901251,0.05736046,0.008805503,0.035302963,-0.012119837,-0.10127077,0.042989403,-0.020581396,-0.08080263,-0.037706558,-0.09769128,0.010862312,-0.06443458,-0.036106486,-0.1185634,0.1018544,-0.08498812,-0.06401948,0.05705042,0.07234354,-0.030569682,0.010127709,0.072103135,-0.017364591,0.037873678,-0.03284029,-0.009530191,-0.001816479,0.07668144,0.094077386,0.056465972,0.012131548,-0.05827548,-0.09714571,-0.059704125,0.051017616,-0.014387373,-0.014485815,0.016797137,0.0061232317,0.03974505,0.09242287,0.0128834415,-0.016440338,0.003553427,0.016859675,-0.12960683,0.059298474,-0.028533002,0.030020047,-0.032751612,0.026727803,-0.09615957,-0.01951627,0.060103964,0.010215103,0.07220218,0.014605166,0.02806536,-0.049200755,-0.02375327,0.004183321,-0.012769569,0.086873926,0.024761247,0.06601065,0.040519472,0.036871765,0.06805779,0.02709593,0.042904634,0.11050479,-0.04099407,0.03472541,-0.007739576,0.03441218,-0.016220909,-0.02211009,0.04128447,-0.08454032,0.007347527,0.023257114,-0.13478121,0.00011572814,-0.0132621275,0.03414996,0.026696956,-0.09390193,-0.04312578,0.09172538,-0.06830137,0.0004799737,0.020785427,0.02031987,-0.028019005,0.09884649,0.019271003,0.043862857,0.02563976,0.053926464,-0.011802104,0.0704719,-0.02421144,0.04804991,-0.005848994,0.011648939,0.04798614,-0.1252717,3.288981e-33,-0.019456131,-0.054781474,0.065187186,-0.007501659,-0.042386338,-0.025813172,-0.028757174,0.0057652905,-0.08046179,0.02024091,-0.07274963,-0.05723175,0.016246242,0.005964628,-0.06951134,-0.01875159,-0.030596418,0.03656317,-0.016109858,-0.07012738,0.015068038,0.06878283,-0.03174837,-0.021302843,0.04089913,0.09551339,0.00087383954,-0.029032491,0.11643138,0.032565746,-0.01139475,-0.112386234,-0.04449122,0.06180918,-0.04418361,-0.050948504,0.089274585,-0.10112793,0.0020972728,-0.038857754,-0.04512828,0.007768997,-0.040339537,0.0066809887,0.033830844,-0.08304352,-0.073040664,0.060271572,0.0154080335,0.036010746,-0.03526053,-0.07552588,0.11632061,0.036285188,-0.07641619,0.08632715,0.0111341085,0.011700196,0.036137935,-0.0010413564,0.03150935,0.043074112,-0.026441537,-0.057036944,0.026715953,-0.00038315455,-0.04800049,-0.030826414,0.028541438,-0.0048025185,-0.047497995,0.01285914,0.07267128,0.0076405397,0.05006772,-0.07389565,-0.054203242,0.072682716,-0.07512656,0.07060675,0.019589115,0.049026802,0.049963646,-0.0020918692,0.06411755,0.07277333,-0.014997905,-0.1155102,-0.054003447,0.10525757,0.018980764,0.022379078,-0.032938745,0.057842568,-0.042235848,-2.8943147e-33,0.024004633,-0.017606355,0.012892095,-0.0076963953,-0.032627646,-0.02596655,-0.025144435,0.08323031,-0.01638705,-0.04671735,0.034172975,-0.058750536,0.06776249,-0.010429143,-0.018469714,0.0007923424,0.067538105,0.04917076,0.075952664,-0.029271215,-0.050845593,-0.037256964,-0.025260853,-0.08077293,0.05753377,-0.02631243,-0.012580561,0.029448513,-0.002502307,0.008032318,0.021293957,0.04131545,0.020300271,-0.024050059,-0.07474965,-0.04253435,-0.11063528,-0.052944068,0.0753015,0.0589419,-0.008207106,0.042933736,0.024069417,0.050192457,0.047305733,-0.008640281,-0.0446874,0.084591575,0.07536934,-0.11789414,-0.022107715,-0.017962845,0.011412954,0.019955918,0.025472732,-0.07178109,0.055569153,0.069059856,-0.014707018,0.03698026,0.04854112,-0.05142691,-0.020980338,0.022891643,0.10322728,0.10837456,-0.09827974,0.0058744033,0.0049666855,-0.010212131,0.016189802,-0.03948475,-0.010985538,0.018889891,0.028176136,0.053904988,-0.01735965,-0.02633345,0.07792786,-0.017617878,-0.041106082,0.010366326,0.008213638,-0.009113471,0.029763436,-0.068523854,-0.020321313,0.057693638,-0.0060387766,0.03779153,-0.04259613,-0.004518603,0.073154755,0.032743692,0.06672372,-2.8219894e-08,0.051415943,-0.04559614,0.05617151,-0.08442123,-0.04334952,0.025673384,0.0120811025,-0.05601571,0.03357239,-0.016596727,0.027973514,-0.028929807,-0.018170306,0.044820894,-0.008978581,0.070206635,0.012469064,0.046994288,0.03521042,-0.025025282,-0.07018511,-0.0023549632,-0.036215663,-0.05928013,-0.017337546,-0.020736136,0.05472281,-0.0062250397,0.010785176,-0.033918157,-0.04750482,-0.05742899,-0.056832805,-0.06653485,-0.06663975,0.055316653,-0.08553006,0.016919244,0.047597665,0.0029788718,0.036247194,-0.057768278,-0.037470117,0.009809607,0.0063315895,-0.032847974,0.07781513,-0.0031076972,-0.06649821,-0.09903956,0.05130659,-0.0012450112,-0.0008200857,-0.116097085,-0.07981816,0.0031649165,-0.011493756,0.020532424,-0.057427157,-0.025559861,0.0140466625,0.025525868,0.076941974,0.040775254 +3.4.24.50,"A 22.5 kDa endopeptidase from the venom of the jararaca snake (Bothrops jararaca), insensitive to phosphoramidon at 0.5 mM. In peptidase family M12 (astacin family)",384,1.0,0.0346521,0.003962315,-0.10945994,0.016776804,-0.024972424,0.04351553,0.043417804,0.07619953,0.020347254,0.06996481,0.08609806,-0.09005635,-0.02852782,0.11426702,-0.062082153,-0.014646093,0.006351689,0.001956421,-0.019212352,0.0094498135,0.09462759,0.06934016,0.057011653,0.019148093,-0.06123393,0.006050945,-0.047202535,-0.08050084,-0.036438804,-0.09388532,0.0072533605,-0.068738356,-0.015703691,-0.09859615,0.07888305,-0.0758799,-0.049986478,0.03373893,0.0959141,-0.007554615,0.019304538,0.079148024,-0.028524159,0.032752465,-0.04887304,0.015101044,-0.021788524,0.06251334,0.09817049,0.016179131,0.0078168,-0.044533778,-0.112778865,-0.04275944,0.039167486,0.011553057,-0.08669874,-0.0095696105,0.036927465,0.03782515,0.087944485,0.009261748,-0.004887325,0.04907912,-0.027983097,-0.11891654,0.012134347,-0.0792689,0.026088348,-0.016007101,0.00025048768,-0.08177689,0.025762876,0.067281134,0.051536955,0.06282187,-0.0027757622,-0.0029774024,-0.09596449,-0.028272258,0.0022753463,-0.018402858,0.066305414,0.03513966,0.088354394,0.007285772,0.05388933,0.08788828,0.049758054,0.051899042,0.08813749,-0.05051348,0.02205638,-0.02191789,0.015919166,-0.01311094,-0.0060161618,0.02783177,-0.0787124,0.023452038,0.0067424774,-0.083011635,-0.02727538,-0.013134535,-0.0017531138,0.018313657,-0.081777796,-0.06619851,0.099038884,-0.04151225,-0.006637814,-0.018811647,-0.043334343,-0.061169162,0.07827784,0.013134353,0.024206826,-0.038116675,0.01562216,-0.025225576,0.049159322,-0.06331384,0.018827453,0.031947162,-0.014368723,0.070669726,-0.12953714,3.591858e-33,-0.015755855,0.022774553,0.09350442,-0.032554038,-0.016558018,-0.031422388,-0.04478791,-0.0075573283,-0.04612197,-0.036741447,-0.120006606,-0.044640046,-0.007882342,0.0334837,-0.05147887,0.028688187,-0.061983224,0.06441994,0.008324619,-0.028206777,0.029145744,0.06445304,-0.036457323,0.016533872,0.046816524,0.0336623,-0.06322805,-0.0093363505,0.07564789,0.01635915,0.012868846,-0.10078548,-0.034416683,0.038473222,-0.07977324,-0.050514203,0.037865363,-0.13546258,-0.0053742155,-0.03751804,-0.039667763,0.017337099,-0.033456165,0.03833412,0.036881484,-0.079200186,-0.04347995,0.04079461,0.028388461,0.030694457,-0.064824656,-0.033187382,0.12391933,0.031081198,-0.074928485,0.07852196,0.027516283,-0.011184121,0.053688213,0.012904717,0.026181838,0.022942575,-0.03659068,-0.038038608,0.03201901,0.031877957,-0.054171186,-0.021667292,0.033100344,-0.02191299,-0.05927391,-0.018853277,0.028321113,-0.0074106995,0.047264196,-0.044987075,-0.047025885,0.044344112,-0.05207744,0.06705758,0.049894463,0.034969777,0.036687605,0.0031724628,0.03870533,0.05401971,0.025589043,-0.11263868,0.0003395751,0.10480972,0.015036747,-0.033996575,-0.028884364,0.014801185,-0.056470178,-3.114302e-33,0.043235656,-0.0092712585,0.021826467,0.022616798,-0.0043973476,0.02773774,-0.005981885,0.091014355,-0.004609531,-0.06553875,0.061646227,-0.065293424,0.04844104,-0.0175437,0.0047088466,-0.025395265,0.08564514,0.0787691,0.072536,-0.040326364,-0.042509813,-0.013151083,0.0052855453,-0.012892323,0.07518442,-0.018886488,-0.002169792,0.013014232,-0.045953363,0.027253974,-0.0060474435,0.025130922,0.014926202,-0.019002048,-0.034110963,-0.011888042,-0.113567345,-0.06493676,0.039009105,0.06024133,0.021154402,0.03034445,0.021749312,0.034338813,0.023129117,-0.004250378,-0.041339792,0.10954593,0.060322385,-0.121207684,-0.006998836,0.009954792,-0.007313062,0.007926328,0.027381603,-0.04630844,0.037839532,0.09347984,-0.004553146,0.013703524,0.0153935,-0.063740775,-0.02385067,-0.005060853,0.09592637,0.09377898,-0.08234262,0.03133709,-0.018484283,-0.0015328255,0.00782851,-0.05392784,0.0069055585,0.022229185,-0.022186872,-0.022032464,-0.024251554,-0.027204309,0.07991026,0.025674725,-0.03881271,0.004460506,0.02290552,-0.006869249,0.07457774,-0.06444846,-0.00955626,0.041391023,-0.018407812,0.056952808,-0.053804215,0.010199889,0.02802752,0.03767651,0.08097191,-3.467833e-08,0.08356743,0.0020432957,0.047502097,-0.083439335,-0.010386372,0.016734885,0.019936845,-0.07406302,-0.0045983633,-0.015155126,0.075305134,-0.015629135,0.01263548,0.05062642,0.0030293989,0.05196137,-0.016042657,0.05418144,0.045964897,-0.024799326,-0.061957914,0.039569963,-0.04976465,-0.05445209,-0.002334212,-0.0122865625,0.046856232,0.02435499,0.017274372,-0.016131887,0.009419746,-0.08282854,-0.06487135,-0.04241962,-0.06898175,0.058723822,-0.10373735,0.018635154,0.025477264,0.03237063,0.026451187,-0.043143906,-0.028623722,0.032593008,-0.03126747,0.02033446,0.065546475,0.007301714,-0.09920508,-0.09100922,0.058602735,-0.0035682435,-0.011627054,-0.09802012,-0.12038284,-0.039633036,-0.022195792,-0.01610982,-0.10455024,-0.04027336,0.0015791792,0.021167157,0.11213871,0.05652958 +3.4.24.51,A 70 kDa endopeptidase from the venom of the king cobra (Ophiophagus hannah),384,1.0,0.0022494306,0.052783348,-0.08411852,0.073148146,-0.05000924,0.012769329,0.031097386,0.024344372,0.016766937,0.02937754,0.03170653,-0.121426016,-0.044528063,0.12021009,-0.047434412,0.049968522,0.027033275,-0.04894813,-0.013904863,-0.008560095,-0.009623582,0.060865555,0.03873445,0.0054538012,-0.08819072,0.00876797,-0.0794199,-0.051028352,0.011806485,-0.083490916,0.0143954,-0.12804481,-0.0075959684,-0.07263864,0.0495438,-0.07310559,-0.06132284,0.025751242,0.04515141,0.026314357,0.035619877,0.11016385,-0.04063804,0.015076,-0.046149526,0.04493619,-0.04170128,0.030610574,0.044823308,-0.0068761036,0.02768501,-0.09510934,-0.12592298,-0.013571474,0.075693466,-0.087210394,-0.05774013,-0.04967347,0.043281894,0.04731227,0.08088562,0.021928672,-0.029388107,0.035702158,-0.030572096,-0.13536832,0.035177406,-0.05197474,0.0057746973,-0.03920026,-0.019702155,-0.035030648,0.04561466,0.050986733,-0.00046132482,0.03322578,0.03596551,-0.017427785,-0.024393117,-0.0018845171,-0.0022038773,-0.0013471444,0.053644866,0.07085342,0.125718,0.041692853,-0.0086507015,0.09936291,-0.021168096,0.045465417,0.07653,-0.054104026,0.0106091,0.006602364,0.067686714,0.0011596044,0.0071408344,0.014470951,-0.08254459,0.02890036,-0.032379624,-0.042800423,-0.009076651,-0.028137254,-0.017745106,0.0016832172,-0.051612258,0.02521515,0.087731935,-0.036096696,-0.0038215683,-0.006993073,0.044638667,-0.04741673,0.09557905,0.03418579,-0.018608876,-0.031017654,0.00919851,0.029211743,0.06915973,-0.06384715,0.06754709,0.05720607,0.018986562,0.041680906,-0.080091424,-1.2326746e-34,0.058107976,-0.008077344,0.069604576,-0.021778155,0.006164965,-0.031462897,-0.026364654,0.0014815963,-0.06296508,0.05618839,-0.07976826,-0.074516095,0.0030975337,0.05972499,-0.043069154,0.024743743,-0.08335034,0.06295002,-0.03325447,-0.052329876,0.051411573,0.01111508,-0.02571106,0.016469877,0.04250261,0.06482471,-0.095940135,-0.023969086,0.040949482,0.02695443,0.01701769,-0.111960836,-0.058771588,0.041542973,-0.067143604,-0.019346427,0.021491773,-0.15266664,-0.019894939,-0.038803473,0.024138553,-0.0013101234,-0.04713866,0.036131997,0.035113607,-0.0364793,-0.024036098,0.034453318,0.05396642,-0.00086336257,-0.0320696,-0.036080856,0.089769885,-0.011818163,-0.11273228,0.071742706,0.032632336,-0.011492893,0.06263076,0.005920077,-0.011781741,0.03759522,-0.07986709,-0.022892546,0.025098098,-0.007551473,-0.053861983,-0.057665568,0.007352018,-0.03599911,-0.02394415,-0.014827876,0.047713067,-0.056672446,0.039833795,-0.037622575,-0.06507478,0.025745109,-0.075141475,0.027065633,0.06630577,-0.0044947634,-0.0118195275,0.004693202,0.051869158,0.042303395,0.046381578,-0.10761617,0.013393211,0.09723455,-0.012104829,-0.011549862,-0.039203037,-0.010417623,-0.03904478,4.2122963e-34,0.02159396,0.029121522,-0.0025641115,0.008139324,0.030808328,0.054764923,-0.02091798,0.14731213,-0.026310263,-0.10126642,0.050912146,-0.017660443,0.09255036,0.047972377,0.019137768,-0.00900602,0.031174434,0.053835984,0.08463499,-0.06711977,-0.10391636,-0.05110853,-0.011832399,-0.031093914,0.110795006,0.06992307,-0.0057401364,-0.007284475,0.033132724,0.031106573,-0.03267435,0.05932321,0.04949735,0.024631727,-0.07159503,-0.004819164,-0.09784115,-0.071807876,0.07356089,0.027366906,0.03231587,-0.0040992303,0.05131827,0.048104543,0.04080684,0.024636704,-0.022414835,0.09687309,0.07304935,-0.09557637,0.021134507,0.013616792,0.004584498,-0.0004128096,0.010371969,-0.011621462,0.02389429,0.023593849,0.05577068,-0.039214004,0.0150715895,-0.027948922,0.011573194,0.055183556,0.04572633,0.10092258,0.015899315,0.01807921,-0.04126406,-0.05339105,-0.01975282,-0.038951647,-0.023100087,-0.04183217,0.010262737,-0.020471185,-0.009352165,-0.011845807,0.07871993,0.0318045,-0.03239048,0.025843767,0.052742343,-0.04125381,0.0776703,-0.042436384,-0.06461074,0.08539902,-0.0033613748,0.019593906,-0.07203719,0.021720981,0.01878341,0.01486885,0.08925354,-2.1839595e-08,0.05003821,-0.009887876,0.036788844,-0.073279634,-0.008495832,0.015689034,0.070840165,-0.050331134,-0.017941156,0.0005648074,0.10273219,0.0066207806,0.023924248,0.06270524,-0.010159251,0.0006662342,-0.044492427,-0.04388049,0.05898612,-0.0479869,-0.041676454,0.015700236,0.031920396,-0.07769211,-0.018899065,-0.034498394,-0.0023186018,0.05640165,0.01861058,-0.009557274,0.023651674,-0.025459591,-0.03582673,-0.050793473,-0.06958519,0.061488178,-0.07687255,-0.017373964,0.01610957,-0.0060355337,0.0665376,-0.038657133,-0.006009047,0.014959064,-0.050451625,0.013716078,0.06673853,-0.034040384,-0.05570154,-0.100793235,0.08820645,-0.031898282,-0.010990642,-0.06469362,-0.11324916,-0.021374663,-0.020588933,-0.025888493,-0.045588985,-0.07207308,0.016908513,-0.016577112,0.09499874,0.04259794 +3.4.24.52,A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family),384,1.0,0.00857775,0.022676803,-0.14881396,0.033136174,-0.019518975,0.031113714,-0.0004884737,0.06649935,0.03361366,0.026935006,0.026018823,-0.068022,-0.016800804,0.07876841,-0.07147424,-0.048418082,-0.020874895,-0.015018327,0.012203575,-0.053375635,0.031780962,0.10116212,0.052291255,0.039677393,-0.06755066,-0.023218988,-0.028763277,-0.109201364,-0.009899713,-0.104305774,0.06255164,-0.09272901,0.03705682,-0.10756406,0.10826633,-0.051113546,-0.084733896,-0.027540302,0.08128033,0.009240065,0.0739156,0.07629834,-0.035250224,0.044153135,-0.010173319,0.020465726,0.017694233,0.020421285,0.055228334,0.035263926,0.026029255,-0.002678973,-0.11384147,0.003093622,0.011501743,-0.031804353,-0.07616256,-0.051401142,0.04359449,0.053114157,0.044433966,0.018071122,0.03462425,-0.03242564,-0.06019932,-0.10368218,0.019420985,-0.059836466,0.011947549,-0.023292638,0.034031358,-0.00936641,-0.050156213,0.08528582,-0.015975397,0.071352035,-0.0111300275,0.04414592,-0.08635088,-0.013631377,-0.019146383,-0.027306858,0.12128202,0.090338685,0.07737334,0.0841661,0.01167246,0.060588147,-0.03815173,0.046857852,0.08688504,0.009185555,0.04868917,0.002442306,0.038761366,-0.0050108545,0.004162405,0.030362763,-0.058869757,0.014972319,-0.012671632,-0.09339719,-0.066887386,-0.023005763,0.0059157894,0.028217757,-0.06917664,-0.036687113,0.12182861,-0.05772372,-0.013903948,-0.04178228,-0.0007578247,-0.07245888,0.10954681,0.021867268,-6.113171e-05,-0.03087969,0.028921867,-0.0037676028,0.045140095,-0.011686361,0.021709967,-0.0081958175,0.03450395,0.00016916005,-0.12072017,4.0423296e-33,-0.0082649905,0.017945679,0.06506578,-0.021686135,-0.060660794,-0.025305714,-0.055546742,0.006250609,-0.02318607,-0.00054753036,-0.058168255,-0.0698633,0.0035396132,0.0028404843,-0.0760736,-0.02062433,-0.041733358,0.048729215,-0.013788186,-0.0395318,0.029654335,0.05983151,-0.036147922,0.015508791,0.026835069,0.0879459,-0.10033874,-0.028521819,0.09704557,0.030973187,-0.0557583,-0.10722748,0.0017500236,0.023069084,-0.06673867,-0.057672627,0.035343535,-0.10061668,-0.06203611,0.0114929015,-0.014559787,0.009898367,-0.067824766,0.0028588988,0.029361563,-0.06132845,-0.020980893,0.043777082,0.031735748,0.050018664,-0.07978683,-0.0393537,0.17335398,0.02008218,-0.07633836,0.012666675,0.004693269,-0.024964087,0.08733357,-0.010909411,0.08383594,0.030544773,-0.068972364,-0.028949814,0.038187552,-0.0027368467,-0.009177117,0.009170319,0.056608073,-0.0040983697,-0.049384,0.020516701,0.009895792,-0.04531401,0.046175167,-0.034924313,-0.10447172,0.03741495,-0.03832468,0.02935184,0.0028194962,0.03683143,0.063567705,-0.03029858,0.08445102,0.0432786,0.11285412,-0.07829605,-0.018409166,0.11649576,0.0028602981,-0.066260986,0.007050112,0.016221471,-0.010554159,-2.5646069e-33,0.034112513,0.016119933,-0.03701221,0.030168448,-0.039393734,0.030762643,0.012394427,0.08123501,-0.03160957,-0.05573762,0.071689025,-0.02697582,0.024719495,-0.0031795613,0.029266872,-0.021765135,0.047020104,0.010650861,0.06607185,-0.036583934,-0.095581576,-0.065908454,-0.005813672,-0.056333885,0.103864856,0.040360957,0.0056453613,-0.0359196,-0.009201936,0.029310849,-0.044702996,0.033006635,0.018142639,-0.0102155665,-0.087868825,0.025444888,-0.06329472,-0.02378439,0.04032036,-0.026678978,0.027408019,-0.018957557,0.058250364,0.057184663,0.022881923,0.026025107,-0.037836794,0.12814231,0.030224197,-0.058136005,-0.0025048961,0.015689006,-0.0014633326,0.042570405,0.010148988,-0.087743185,0.031869113,0.07852137,-0.05172526,-0.009739014,-0.021297393,-0.025094906,-0.017525049,0.06805415,0.10067972,0.07543613,-0.050210368,0.024112012,0.0069698677,0.00063248194,-0.010052805,0.0030423643,0.026787635,0.00068384304,0.04082415,0.02637173,0.010948537,-0.0013933142,0.07040223,0.023982156,-0.099174984,0.0043706493,-0.013367578,-0.04635673,0.02429224,-0.107428625,-0.043024182,0.056517933,0.011170834,0.049167994,-0.039696492,0.00046253172,0.058267705,0.031553186,0.008144321,-3.3669775e-08,0.01740594,0.010185443,0.011863246,-0.051874198,0.03304254,-0.00821217,0.0043426105,-0.029253863,0.0028529568,0.036376175,0.08681877,-0.03391043,0.05735658,-0.020800112,0.018996121,0.022432,-0.013994447,0.02876783,0.07497497,-0.036693458,-0.044179164,0.022859711,-0.049899224,-0.043318614,0.014774697,-0.051913477,0.0009826637,-0.0344524,0.0053672823,-0.011955986,0.044782817,-0.061504696,-0.024574194,-0.05460516,-0.009271909,0.022776159,-0.04034855,0.01603562,0.09362829,0.04230982,0.041143663,-0.03098762,-0.05170961,-0.025931764,-0.037729904,-0.0015920411,0.048912518,-0.035919223,-0.06535272,-0.06648631,0.0059596687,0.00938233,-0.029706473,-0.07130714,-0.051872067,-0.02317184,0.04566848,-0.04085821,-0.0765327,-0.06244852,-0.0037088357,0.040931415,0.14927986,0.07610025 +3.4.24.53,A 24 kDa nonhemorrhagic endopeptidase from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family),384,0.99999994,0.01753359,0.014664217,-0.13794546,0.042603914,0.0028494685,0.026790256,-0.0009729641,0.063609034,0.023948858,0.031021075,0.04173499,-0.08921167,-0.027980946,0.0894667,-0.07880497,-0.029503698,-0.017262675,-0.031173777,0.025454348,-0.030234532,0.047208328,0.10403452,0.06262817,0.034557194,-0.0565538,-0.005529552,-0.04330074,-0.1031762,-0.0074709994,-0.098771386,0.067758836,-0.095880695,0.03507932,-0.09254209,0.10784937,-0.034355786,-0.07914529,0.0052954177,0.08434995,0.0057620816,0.049676824,0.08024532,-0.041163772,0.047163166,0.000490689,0.004094976,-0.012747812,0.043038804,0.05308036,0.047181133,0.026044527,-0.030931102,-0.11854873,-0.005781485,0.04471981,-0.02279623,-0.0780931,-0.059274893,0.03338511,0.033423223,0.08105288,0.0142215155,0.027948853,-0.028123107,-0.044640798,-0.106055364,0.022297937,-0.03210228,0.038402792,-0.016421158,0.034529645,-0.040970564,-0.032984726,0.09589695,-0.0008412208,0.06501382,-0.017457513,0.046982273,-0.08848832,-0.02353622,-0.01690473,-0.027797952,0.1267485,0.07929523,0.08567304,0.053649254,0.020896146,0.09104019,-0.026595129,0.043691076,0.06474068,-0.0078148255,0.05036172,0.0016320209,0.024711575,-0.021235347,0.0076804664,0.020043664,-0.07328491,0.012758768,-0.006434927,-0.09264917,-0.06433866,-0.00852785,0.008634638,0.030608192,-0.08673111,-0.05932623,0.10377436,-0.06631405,-0.01964001,-0.014540472,-0.011076222,-0.0819165,0.11665637,0.004804348,0.0009030258,-0.023416638,0.026891034,0.015616176,0.054304488,-0.021103358,0.009315879,0.009500953,0.024127526,0.027580475,-0.10883432,3.9195004e-33,-0.009904901,0.0065838965,0.056289975,-0.03170519,-0.040057324,-0.027241759,-0.041905247,0.01717412,-0.020288093,0.021695707,-0.07459772,-0.080880135,0.0070293555,0.007889999,-0.059924796,-0.0018836122,-0.053377323,0.039924767,0.004462265,-0.04957568,0.026298886,0.0580654,-0.045577787,0.0051090056,0.022716567,0.06052923,-0.10001957,-0.00178721,0.08696456,0.02772441,-0.03456868,-0.109023556,-0.009598739,0.022993652,-0.06861167,-0.053346556,0.031122072,-0.11898026,-0.044143908,-0.011066905,-0.012609091,0.01067952,-0.065860316,0.008533426,0.032672927,-0.070439175,-0.012993923,0.055752873,0.041089136,0.03487052,-0.071698345,-0.05771512,0.16057715,0.017299667,-0.08788602,0.05928638,0.02640865,-0.009971944,0.07528463,-0.010758898,0.04671582,0.01880517,-0.07062293,-0.048662573,0.01817639,0.0071084346,-0.005651689,0.00762799,0.04903559,-0.022007558,-0.05886165,0.02221055,0.018861186,-0.048297673,0.039707743,-0.023403848,-0.09938537,0.029412003,-0.041879833,0.033414688,0.024073394,0.03865702,0.059756108,-0.018217184,0.07818696,0.04584771,0.07653231,-0.088329844,-0.024384594,0.12882335,-0.0020019705,-0.051364854,-0.010890999,0.006979591,-0.017559921,-2.6288537e-33,0.042695474,0.016821297,-0.039634362,0.017089924,-0.029244775,0.040917873,0.004742334,0.09578035,-0.027330827,-0.06866172,0.057477936,-0.029496908,0.04390847,-0.017263576,0.016909862,-0.013205991,0.060993638,0.04031222,0.09006591,-0.064081855,-0.08151099,-0.07494994,-0.013127622,-0.0735667,0.10038633,0.050878543,0.0063885767,-0.01712026,-0.0075742877,0.023465997,-0.015799472,0.036992744,0.02787166,-0.036243543,-0.08067781,0.037839387,-0.09046488,-0.039852455,0.028515344,-0.019204963,0.029937575,0.0038786079,0.049510814,0.062179144,0.016294677,0.024893181,-0.045457527,0.11085202,0.05029745,-0.08512646,-0.00010278258,-0.0039960197,-0.009337915,0.047469985,0.010653096,-0.07648437,0.031032715,0.07087758,-0.006842626,-0.015822519,0.00052744074,-0.018559279,-0.01933381,0.04676103,0.10361408,0.059331454,-0.07581,0.024234453,0.013119501,-0.0038474142,-0.009217492,-0.0098383,0.00816577,-0.0056879697,0.017494757,0.0197932,-0.0003135028,-0.0073815435,0.09051384,0.0059096315,-0.05534133,0.007518017,0.0150740575,-0.023425087,0.028923944,-0.10362242,-0.05284107,0.06096151,0.01985912,0.07289035,-0.035825185,0.0066904016,0.06026973,0.029570363,0.033014134,-3.2327918e-08,0.04291946,-0.008587481,0.022967832,-0.06910275,0.027494896,-0.015326734,-0.00179764,-0.04392211,0.014487697,0.019609632,0.09058585,-0.0415817,0.037238363,0.008328046,-0.0051041343,0.017607959,-0.0065017887,0.024913857,0.053907305,-0.037753228,-0.056019958,0.03478322,-0.04831009,-0.047760926,0.034481585,-0.044930473,0.01766774,-0.01915013,0.025681384,-0.024574965,0.026378596,-0.057755813,-0.028696287,-0.039947774,-0.043484837,0.06195916,-0.054426648,0.018141232,0.07260038,0.012520105,0.029501038,-0.035773817,-0.043666545,-0.011326018,-0.03620007,-0.0040338384,0.046798207,-0.0065285335,-0.07586666,-0.0907079,0.022189163,-0.019919584,-0.03934961,-0.072637536,-0.07873663,-0.038319297,0.031848945,-0.041006822,-0.05171021,-0.079844326,-0.0059619485,0.031849135,0.14983822,0.08737555 +3.4.24.54,A 94 kDa hemorrhagic and fibrinogenolytic endopeptidase from the Chinese habu snake (Trimeresurus mucrosquamatus) venom. In peptidase family M12 (astacin family),384,0.99999994,-0.0045841103,0.019525232,-0.09467616,0.02798113,-0.002689779,0.014484418,0.009414489,0.067880556,0.0029153533,0.033149842,0.00982607,-0.09108682,-0.01638953,0.10935241,-0.06361067,0.004563145,-0.005501892,-0.017690828,0.06242351,-0.03751983,0.051182315,0.09578375,0.027869109,0.03627672,-0.07957768,-0.029701384,-0.0361155,-0.07778298,0.007001459,-0.07906793,0.01727703,-0.09376954,0.035600785,-0.084682606,0.11269856,-0.054906588,-0.08094738,0.004118135,0.06087475,-0.016384428,0.059611157,0.082777604,-0.026872553,0.020605946,-0.021209998,0.013092131,0.0274497,0.019940946,0.058010876,0.045184053,0.021798411,-0.00738374,-0.09998696,-0.01309933,0.041524287,-0.026013171,-0.08820044,-0.05952075,0.020644315,0.023282412,0.016458472,0.03817153,0.0384942,-0.0163562,-0.026136069,-0.0794203,0.005353287,0.002114147,0.022067564,0.011219206,0.015400379,-0.029648568,-0.031295225,0.09840298,0.00053420314,0.07937025,0.027890159,0.05828816,-0.074875094,-0.0442845,-0.042111322,-0.015402323,0.14867291,0.058790315,0.0867074,0.09131345,0.01667416,0.033481665,-0.03933246,0.035314925,0.087443255,-3.668286e-05,0.04129057,0.005962079,0.06687988,-0.008590721,-0.0012933733,0.074850015,-0.051941287,0.004490242,-0.016470436,-0.07556814,-0.054730676,-0.023630334,0.023225516,0.020387435,-0.08541136,-0.05189476,0.13684963,-0.06740349,-0.026241036,0.00038790298,-0.0018330084,-0.060418833,0.1293895,0.008598671,-0.005334582,-0.002581093,0.021797376,-0.000105360334,0.055079836,-0.025135031,-0.007997348,-0.030196218,0.029525321,-0.01247068,-0.108663745,6.3502504e-33,-0.018523818,-0.023155596,0.042606253,-0.006084904,-0.069460474,-0.022728369,-0.045256365,0.02200721,-0.041354723,0.027770352,-0.05155759,-0.07240651,0.0073516034,0.0068911416,-0.07462154,-0.032093495,-0.040491417,0.047169276,-0.010461509,-0.05531287,0.04338334,0.044895574,-0.035985928,-0.004141244,0.010436424,0.07846287,-0.086548544,-0.0134070935,0.10078129,0.03515759,-0.0615409,-0.120456666,0.007781014,0.01853882,-0.09699387,-0.06433485,0.042353775,-0.08818466,-0.06110331,-0.028133268,0.011195053,0.025385566,-0.1152048,0.0024596648,0.023436448,-0.062183633,-0.03662986,0.038890377,0.037284832,0.03175098,-0.078243844,-0.06448605,0.1630127,0.0076952116,-0.052816704,0.030022291,0.013618031,-0.04282323,0.04670988,-0.03253907,0.05805984,0.0112733785,-0.0769231,-0.04608268,0.026767585,-0.026724484,0.009253257,0.0073888963,0.060058624,0.009083674,-0.0356869,0.03840768,-0.014327693,-0.04929058,0.035975996,-0.039217602,-0.0979149,0.007800847,-0.04692102,0.027339224,0.022990646,0.047923982,0.061421707,-0.038665086,0.0910421,0.03962898,0.10478006,-0.08750569,-0.0061007338,0.10943244,-0.021865623,-0.073738426,-0.01188709,0.011476631,-0.039854705,-4.5017195e-33,0.01975309,0.024965882,-0.034587782,0.017228007,-0.02814178,0.024677379,0.019082002,0.10284952,-0.025160054,-0.048732076,0.062076543,-0.04032038,0.00827885,-0.007029604,0.0182965,-0.004261804,0.06021244,0.017432144,0.05802148,-0.059193853,-0.08249453,-0.061535217,0.013701776,-0.07177116,0.09189107,0.060592376,-0.023732813,-0.0028453495,-0.017254947,0.025826937,-0.04068104,0.05185925,0.04704988,0.012522325,-0.0991015,0.007997493,-0.08236875,-0.003886908,0.051330354,-0.044247504,0.030356592,0.018475264,0.042131618,0.07988085,0.010254716,0.045846146,-0.06715519,0.10001764,0.028559266,-0.053946402,-0.008372422,0.008176892,0.024538636,0.03147763,-0.019235032,-0.08220658,0.0290492,0.067095414,-0.043902602,0.008090566,-0.0045926594,-0.014540345,-0.040240373,0.07343823,0.105669536,0.09825409,-0.036375552,0.033081565,0.0043278337,-0.023852644,-0.0049132714,0.034688007,-0.011223416,-0.02011154,0.03951987,0.037348047,-0.0023290128,-0.019950226,0.073765375,0.016756617,-0.069219574,0.023451932,0.011538214,-0.018547148,0.015221974,-0.09811628,-0.063993536,0.087957695,0.041490316,0.041223705,-0.034546982,-0.012024547,0.05679796,0.0089716455,0.0140890265,-3.4958763e-08,-0.025815919,-0.024047848,0.0072231507,-0.06412023,0.005722469,0.0062560816,-0.032210514,-0.04140479,0.039768968,0.03510167,0.07377526,-0.052340243,0.020682469,0.007186131,0.02068056,0.0051770695,-0.0040488453,0.026901482,0.06677522,-0.03461718,-0.049616642,0.045120012,-0.044569362,0.012750482,0.02440784,-0.045743056,-0.026693488,-0.043608543,0.007367684,0.0106022125,0.020239396,-0.03773886,-0.028086198,-0.021672776,-0.023122529,0.03034133,-0.053016532,0.00430862,0.067701675,0.023320723,0.07333618,-0.033179674,-0.02239825,-0.03563431,-0.040751923,-0.031952355,0.059926935,-0.0361553,-0.044213686,-0.08451558,0.037639387,-0.013534511,-0.028016515,-0.09864017,-0.09231319,-0.050269276,0.033762544,-0.025661552,-0.039871123,-0.064917415,0.00400955,-0.0006002912,0.17717952,0.08797513 +3.4.24.55,"From the periplasmic space of Escherichia coli. Inhibited by EDTA and 1,10-phenanthroline; not thiol-dependent. Type example of peptidase family M16",384,1.0,-0.08727787,-0.092365384,-0.083239734,-0.051382523,-0.012958524,0.0740596,-0.056815375,0.101426795,0.09103421,0.039838836,0.09012359,-0.0034560447,-0.03369899,0.06533488,-0.0047047646,-0.026166633,-0.08215158,0.02342883,-0.025438063,-0.02342094,0.08625006,0.055650692,-0.007733879,0.014330626,-0.058427338,0.03596968,0.0357994,0.01984754,0.007750799,-0.09155615,-0.020885823,-0.0702161,0.08214217,-0.030883905,0.1288721,0.0030431005,-0.006326617,-0.017176611,0.06119638,-0.05260842,0.04637134,0.026466383,0.020670779,-0.05760118,0.07433552,-0.094271205,-0.047559105,0.111974746,0.009427996,-0.06798715,-0.032689273,-0.022992523,-0.012181689,0.10159634,0.043548025,0.005456604,-0.0095059965,-0.06749867,0.03523287,-0.042918578,0.056313485,0.02894064,0.030914195,0.0008420897,-0.08382441,-0.046504118,0.03170631,-0.009935786,-0.0034544445,0.012263886,-0.02043734,-0.02674585,-0.02854546,0.092380874,0.01208047,0.04206602,0.0017151962,-0.046279345,-0.04543872,-0.029640708,0.015292657,-0.04443288,0.0116778035,0.12843369,-0.044904236,0.035197273,0.039195172,-0.010539539,0.049314886,-0.024224283,0.015535834,-0.028872008,0.013087873,-0.040080845,-0.074250154,-0.0041181194,-0.02909969,-0.07358602,0.0110043185,-0.011412247,0.047033977,0.040679503,-0.08297479,0.02572998,-0.019226983,0.03135221,0.027698014,0.027708497,-0.011472449,-0.015313073,0.004012426,0.0051561403,-0.009546084,-0.010509654,-0.041702367,-0.05004205,0.044497307,-0.030565666,0.06229765,-0.031868674,0.026568215,-0.036239635,0.020159155,0.04760017,-0.039420627,0.017196586,-0.06253929,2.8014218e-33,0.044841412,-0.066151105,0.0086380085,-0.004102813,0.074473426,-0.004190865,-0.050329197,-0.00542218,0.014613974,-0.11708755,-0.0685866,-0.05463214,-0.0074302717,-0.02190032,-0.045871302,0.030986264,-0.055488516,0.02327628,0.0444923,0.010587995,-0.012640883,0.066104956,0.02454635,-0.03424834,0.054824315,0.034728404,-0.009167898,0.037168745,0.010874973,0.017193232,-0.029666733,-0.05084819,-0.079243094,0.0061587566,0.066044554,-0.011753255,-0.029128736,-0.047138225,-0.0138565535,0.051290963,-0.016944416,0.05925783,0.01613874,-0.02756621,0.076954186,-0.013791335,-0.03576496,0.06576318,-0.0329242,0.03155477,0.029006766,0.0041719414,0.06461542,-0.064543955,-0.083431184,-0.02146222,0.01718299,0.016493296,0.07076669,0.053086378,0.028441776,0.09069553,-0.050341997,0.05881503,0.03523365,0.02759114,-0.047169536,-0.056472503,0.021223346,0.11528029,-0.09051778,0.007702333,0.025367372,0.05445382,0.038666837,-0.118689485,-0.07861874,0.08779526,-0.018499592,0.027356412,0.059099365,-0.017744657,-0.0074841003,0.016022554,-0.04886068,-0.019768802,-0.0074873012,0.021481669,-0.017097063,0.011716188,0.10281706,-0.039915264,-0.020457342,0.060336314,-0.024253584,-3.3217872e-33,0.05381035,-0.044057503,0.049624357,-0.047147222,-0.050546378,0.07275722,-0.057230357,0.04225193,0.06071195,-0.044777036,0.04205726,0.0129049625,0.0012425177,-0.043768693,0.053434707,0.022669265,0.036986772,-0.01057024,-0.07687196,-0.021102374,-0.042664304,-0.050063957,0.0060895737,0.046041388,0.01741137,0.03423377,-0.018011633,0.04645079,-0.029450435,-0.025530715,-0.015398611,0.012540429,-0.060954727,-0.07638009,-0.124084815,0.025121883,-0.042770546,0.054553207,0.02014697,-0.042456795,0.032319095,0.060874287,0.002666147,0.04707836,-0.019902984,0.09656595,-0.032575432,0.053519975,-0.015516334,-0.016041653,-0.040109675,-0.058262754,0.01864301,-0.0028766212,0.10869366,-0.06701023,0.062979594,0.021677464,0.012799539,0.02382903,0.011789655,-0.059297666,-0.001846081,0.0015571025,0.026070718,0.023582378,-0.04455412,0.026057746,0.04412537,-0.008618638,0.06046143,0.044331953,0.022856008,-0.057194624,-0.052193403,0.086347416,-0.0015965963,-0.11938134,0.05850416,-0.04511476,-0.037788864,-0.0031039286,-0.07816705,-0.010462308,-0.0030727875,-0.04481584,0.053179733,0.052502073,0.006712383,0.047934107,0.04961345,-0.005727309,0.02379213,0.018934296,0.081736594,-3.1652863e-08,0.096276365,-0.10636656,0.005144275,-0.05540683,-0.047300365,-0.052068055,0.018916754,0.06643209,0.09840012,-0.0116284145,0.026003186,0.100984946,0.041785683,0.022651773,-0.004493685,0.07460404,-0.04591711,-0.00022779018,-0.014039051,0.042195052,-0.06546329,0.0019468422,-0.069202974,-0.059800602,0.012571112,-0.0617175,0.06830984,-0.07382455,-0.04399558,-0.042474903,0.033458095,-0.0133305155,-0.049443033,-0.052667383,0.018354345,0.033641927,0.0012310268,-0.04206473,-0.029866565,-0.020867873,0.055285126,0.0013063699,-0.094966635,-0.031344008,0.030310852,0.04025643,-0.042821825,0.081424735,-0.07628881,-0.028890496,-0.010099663,-0.022966418,0.009374857,-0.09691144,-0.20035902,0.0055654217,0.024368308,-0.10023189,-0.0019006426,-0.045305047,0.07602831,0.016291296,0.18648215,0.07971648 +3.4.24.56,"A 110 kDa cytosolic enzyme, known from mammals and the fruit fly, Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family).",384,0.99999994,-0.044501387,-0.0065864315,-0.057945468,-0.033372905,0.009197415,0.08968458,-0.013004278,0.015137336,-0.012774319,0.05637712,0.04189976,-0.021033779,-0.08616669,0.057236515,-0.07517038,0.11901261,-0.02568807,-0.0033375525,-0.041972205,-0.0760693,0.031674724,0.078449585,0.050758827,0.06964683,-0.060018387,-0.0008390648,0.03257538,0.008631391,0.014593329,-0.093718566,-0.06242241,-0.028985195,0.08644483,0.039227016,0.037541516,-0.032725114,0.026790245,0.016804008,0.02948973,-0.003775802,0.08426457,0.04781786,-0.04444084,-0.053325005,0.014567841,-0.04855751,-0.021522388,0.03548764,0.07700031,0.013818188,-0.039992727,-0.034141053,-0.01777503,0.07459835,0.036279246,0.020116126,-0.042791806,-0.057671666,0.03167924,-0.03804428,0.04821254,0.027018672,0.011579055,0.00088665256,-0.0070299143,-0.038832616,-0.045614164,-0.042767312,0.050376225,-0.043677725,0.014098481,-0.08656428,-0.02152211,0.04498254,0.004792505,0.048042882,0.02818233,-0.054830577,-0.040766966,-0.049544092,-0.0027448977,-0.08576943,0.025263209,0.06877271,0.0021401034,-0.0035188005,0.04330552,0.039730653,0.06531744,-0.02640912,0.030728122,-0.055264693,0.04259242,-0.036991842,-0.0600476,-0.0015623512,-0.031883966,-0.07623839,-0.02587315,0.031141194,0.046060305,0.027818501,-0.026964074,-0.06537769,-0.084949285,0.054857813,0.032743346,-0.003333919,0.051397897,-0.026770527,-0.020010872,0.0051187235,0.02640469,0.050935313,-0.059886184,-0.0649107,-0.013140708,-0.022212878,0.05547179,-0.020663457,0.1069536,0.019237177,0.00930421,0.030009797,-0.036225967,-0.006211389,-0.16493951,6.1272202e-33,0.05803918,0.0033659548,0.016793318,0.0019306383,0.04537664,-0.016341574,-0.035158228,0.03059052,-0.03011578,-0.09801374,-0.11206272,-0.009843732,0.02838761,0.025279777,-0.0709919,0.01887154,-0.008385583,-0.025097508,0.11222859,0.015728343,-0.03471536,0.008887875,-0.081624016,-0.064646855,0.04002384,0.061956245,-0.040741652,0.06354658,0.07850191,0.012111502,0.007090105,-0.0649081,-0.032597505,0.03522622,0.017596118,0.011281841,-0.008803548,-0.09694803,-0.017520588,0.040266518,-0.054310285,-0.040354352,-0.009285467,-0.005275555,0.020730698,-0.081557564,-0.09146366,0.04103729,0.022294072,0.050875135,0.01605278,-0.035643343,0.08859167,-0.03747408,-0.061061274,0.021482654,-0.01940369,-0.039836004,0.042586982,0.04457254,-0.017827317,0.024562985,-0.09300908,0.05622654,0.0062149884,0.009304564,-0.09452402,-0.04833093,-0.09255364,0.04300633,-0.059600346,0.026625207,0.017286386,-0.012957844,0.004044875,-0.113196485,0.008996902,0.057441957,-0.0772984,0.07184221,0.036546674,-0.08474348,0.0043934695,0.030541003,-0.033022683,-0.010455817,-0.017563613,0.035326418,-0.010960959,0.002390845,0.00050784816,-0.092683084,-0.004752084,0.05565817,0.029442348,-6.5897574e-33,0.07293776,-0.07888729,0.051792685,-0.020554343,-0.006213223,0.040449243,0.05039402,-0.005718808,-0.0034846019,-0.09530933,0.04351676,0.008775352,0.07395928,-0.051442042,0.06959999,0.03755713,0.059786674,0.032731615,-0.017828416,-0.0055800825,-0.11342716,0.07833174,-0.01719141,0.040106606,0.0035962684,-0.025514979,-0.010882208,0.09031731,-0.017121913,0.011937976,-0.03168647,0.021491826,-0.029951219,-0.07482726,-0.0331826,0.038374078,-0.057704993,-0.049952444,0.029741876,0.015922675,0.009612585,0.10639384,-0.029304277,0.024707625,0.05857613,0.15055732,-0.052198034,0.04541461,0.013222785,-0.029153094,0.011023372,0.016295929,0.032980055,0.010937028,0.1247179,0.0015148822,0.0390748,0.028555598,0.074622005,0.0095576905,-0.014225086,-0.09853949,0.014001791,0.032342486,0.009059144,0.0685117,-0.057587177,0.07688024,0.038342897,-0.024224931,0.0597723,-0.0115065435,0.033073973,0.025899343,-0.14710866,0.03819029,-0.030875204,-0.059265867,0.049787875,0.007748534,0.04879386,-0.040448386,-0.0143503705,-0.028546322,0.016807387,-0.044541247,-0.026228553,0.07271737,-0.0006033892,0.016233442,-0.0057985904,-0.020756107,0.0046728575,0.0586345,0.039798487,-4.641831e-08,0.10325658,-0.09546604,-0.0084518045,-0.11756658,-0.007925868,0.009304768,0.0488169,-0.0056289444,0.04933083,-0.054904763,0.028747529,-0.016793951,0.04264222,0.04450908,0.071292564,0.06994184,-0.012293253,0.07702595,0.010444721,0.06655409,-0.09081926,0.0674544,-0.09420725,0.04879476,-0.048611898,-0.051995862,0.09069333,-0.01038058,-0.023232933,-0.005660364,-0.045320198,0.022092186,-0.02072795,-0.014616341,-0.027820274,0.031167736,-0.011164042,-0.014587726,-0.008918355,0.01805532,0.055811316,0.013236716,-0.060466167,-0.063826464,-0.009872166,-0.061568424,0.0589816,-0.031651944,-0.04695879,-0.026638404,0.0056680334,0.06188478,0.005972797,-0.05434767,-0.1031123,-0.027806062,-0.01889418,-0.14167266,-0.064249516,-0.057834134,0.05720138,-0.004600373,0.17069249,0.023754608 +3.4.24.57,"An enzyme secreted by the bacterium Pasteurella haemolytica. Inhibited by EDTA (100 mM) and 1,10-phenanthroline. Type example of peptidase family M22",384,0.99999994,-0.09422048,-0.039070982,-0.10978714,-0.0111967875,-0.009959128,0.06550195,-0.05043557,0.07111037,0.042268336,0.034257576,0.052905764,-0.082045935,-0.003349924,0.017551702,-0.03691084,0.03262461,-0.057201616,-0.05531779,0.023379676,-0.075231105,0.09540712,0.082718395,-0.037824374,0.02504896,-0.04241034,0.016479764,0.03128676,-0.022043224,0.03714473,-0.07404755,-0.01597788,-0.08472035,0.100713976,-0.04756608,0.07180565,0.03316254,-0.028920988,-0.019183023,0.046424568,0.019198932,0.07510165,0.0055393702,-0.017906673,-0.06783888,-0.009143132,-0.07264986,0.006925566,0.1430558,0.024472905,-0.015190763,-0.08616201,-0.060703967,-0.04704131,0.031398546,0.00096796616,-0.018150942,-0.005132483,-0.01810515,0.03546377,0.04655943,0.037305288,0.043273967,-0.00031967543,0.006691523,-0.014811609,-0.071855955,-0.011769534,-0.041469302,0.04657493,0.009707811,-0.051843017,-0.084005654,-0.08769364,0.033668887,0.012726646,0.020029638,0.02413779,-0.04180832,-0.079305805,-0.04470129,0.015924267,-0.05212488,0.060967233,0.09784089,-0.0017190513,0.0536037,0.026261315,-0.054361705,0.11092515,-0.06231906,0.028585637,-0.08119874,0.03294356,-0.026175685,0.014385766,-0.036937173,-0.05053902,-0.01356874,-0.0038031058,0.022178693,0.04070673,0.01187929,-0.07135539,-0.043238647,-0.06359205,0.049186826,0.00046643164,-0.015612199,0.07879307,0.026428917,0.0046737157,0.026634641,-0.0028638367,-0.0030174302,-0.019319303,-0.0051913075,0.08532143,-0.06412015,-0.04918388,0.018600706,0.03667019,-0.030663934,0.047667608,-0.027582426,-0.030831156,0.01763172,-0.12066545,2.8926514e-33,0.04967973,-0.040359527,0.020725152,0.022527039,0.0054491037,-0.009493146,-0.04334773,-0.024833303,0.014185071,-0.06669365,-0.041992005,-0.037360936,-0.04277149,0.063605696,-0.06912791,0.039888006,0.022452747,0.02112363,0.09317934,-0.011137738,0.01978995,0.08903764,0.011542128,-0.014715736,0.081119336,0.03471906,0.027866516,0.007044647,0.073084824,0.01703531,0.025527032,-0.11662948,-0.08817649,-0.009733131,-0.019184666,-0.017810589,-0.010817634,-0.08316369,-0.001480884,-0.006314621,-0.008827602,0.018485192,0.012571049,-0.0055966186,0.060550593,-0.079847,-0.042049974,0.066139646,0.03251314,0.049000435,-0.013568349,-0.022678412,0.090387024,-0.040340863,-0.11058855,0.038934235,0.01772892,0.017683337,0.12602736,0.044996563,0.0036756014,0.10817055,-0.034876265,0.018886268,-0.02431075,0.024376294,-0.046945002,-0.07015242,0.03045435,0.11571037,-0.07500147,0.024500404,-0.03282318,0.007330806,0.019472606,-0.15821718,-0.04968176,0.026523143,0.014439794,0.024653282,0.06849209,-0.031259928,0.055152982,0.018488428,-0.08917197,-0.068944655,-0.030258771,0.017627291,-0.05632796,0.04538856,0.053862922,-0.025438314,-0.010726511,0.09588138,0.024945859,-3.31763e-33,0.07799683,-0.079479724,0.03491291,0.0044809375,0.0020481555,0.032186426,-0.018061405,0.06561109,-0.04447701,-0.02962867,0.07434011,0.026375951,0.038636234,-0.052161887,0.061639886,0.010272859,0.087551296,0.03351266,-0.040314764,-0.053468086,-0.061511885,0.0048215524,0.09116319,0.013407077,0.011374185,-0.0065012556,-0.019863116,0.030198153,-0.01313244,0.0078003067,-0.032456495,0.064341776,-0.03184835,-0.058756884,-0.13339168,0.023627914,-0.023917485,0.00949857,-0.020375762,-0.036385216,0.010098629,0.047417622,0.07349501,0.04877109,-0.025296753,0.08321719,-0.012634398,0.00021065262,-0.030738292,-0.018693147,0.013899988,-0.018155593,0.019133314,0.02692782,0.0979524,-0.00072509015,-0.01569426,0.032292325,-0.020861339,0.05115082,0.047851637,-0.053544268,-0.06942389,0.052108664,0.06859504,0.022790952,-0.037969977,0.041394174,0.038150467,0.04559487,0.098480634,0.020645967,0.04488158,-0.01987199,-0.051191967,0.05981106,-0.06780922,-0.07095534,0.023104953,-0.041968323,-0.032770008,-0.04078628,-0.0030334091,-0.013151702,-0.0066306456,-0.11675973,0.029655028,0.05553267,-0.016058404,0.0758685,0.010266463,-0.05793435,0.009068328,0.04084754,0.1005276,-3.0415375e-08,0.076449834,-0.110931695,0.057909172,-0.04161241,-0.06495427,-0.09537546,-0.04498246,-0.0021081588,0.07674932,-0.0063849203,0.020077655,0.006815863,0.057857826,0.02623858,0.040900595,0.048953544,-0.010559234,0.034511395,-0.018895226,0.031879038,-0.029451706,0.0050971573,-0.04742223,0.0006335882,0.024434742,-0.07865699,0.021077551,0.011433499,-0.062438987,-0.0031823893,-0.030911943,0.026901517,-0.06704422,-0.035510376,-0.04243012,0.048824854,0.012840292,-0.037161313,-0.0317451,0.0059182015,0.07118606,-0.02206316,-0.053556085,-0.02396857,0.008247497,0.019396668,0.03434009,-0.008772592,-0.04312475,-0.09200368,0.022106599,0.030575959,0.01482527,-0.04366158,-0.12738542,0.0085333465,-0.01734885,-0.0711191,0.024675118,-0.053724106,0.093282975,0.00052600616,0.17378178,0.05166734 +3.4.24.58,This enzyme from the venom of Russell's viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family),384,1.0,-0.05933807,0.034464598,-0.095368735,0.011317705,-0.0017303595,-0.011838407,-0.019143324,0.022428392,-0.0066350456,-0.019453473,0.02257646,-0.068715505,0.04245461,0.08886999,-0.041202318,0.03501164,-0.051885646,-0.013381292,-0.026537985,-0.080356866,0.0664375,0.074274376,0.053973738,0.004266851,-0.098634325,-0.013405722,0.012634742,-0.054785248,0.025195267,-0.109440245,0.016043782,-0.047540095,0.008548267,-0.08097985,0.07900464,-0.025284432,-0.053430732,-0.038442988,0.0071115103,0.016659165,0.06601712,0.10487308,-0.03167707,0.0144146755,-0.00815961,-0.031136004,0.008144035,-0.007002007,0.072700806,0.0052512325,0.0029864956,-0.031564772,-0.080000766,0.015034541,0.08035015,0.040504117,-0.09766814,-0.056278426,0.022729335,-0.026672564,0.11263539,0.020063495,-0.028941283,0.0051788576,-0.006462348,-0.059503566,0.013025506,-0.038171384,0.0020880722,-0.05730625,-0.052333906,-0.10476037,-0.0068611316,0.06321769,0.008987517,0.016500073,0.03827164,-0.069089964,-0.04978227,-0.04833077,-0.0156397,-0.0032248322,0.097482264,0.09673201,0.08104004,0.07780892,0.0451588,0.048795927,0.020719346,0.07739846,0.1145711,-0.022080049,0.037360184,-0.051549155,0.02937559,0.048356436,0.065744616,-0.0056494204,-0.020843115,0.061705817,0.035094846,-0.01182346,-0.029477535,-0.018759554,-0.020699304,0.030453304,-0.022840438,0.075493865,0.02035987,0.0039506867,0.030965215,-0.01355113,0.012637967,-0.05931873,0.053472325,0.047848918,0.023408806,0.0018183972,0.018481344,-0.013012632,0.062131707,-0.03542181,-0.009049279,0.046427973,0.0057782433,0.061583865,-0.18097436,3.2129306e-33,-0.009798102,0.037968434,0.014583935,-0.0135241,-0.055288825,-0.029138133,-0.06507966,0.008763338,-0.10930423,-0.01636844,-0.08314806,-0.044466797,0.014885205,0.0185699,-0.069376774,-0.051050942,-0.0009749316,0.051745858,0.026872719,-0.039536763,0.029508892,0.028723419,-0.03509872,-0.04647281,0.08615143,0.048900984,-0.020826599,-0.008174696,0.072175376,-0.010353826,-0.020979483,-0.09649418,-0.04967394,0.048115063,0.011477276,0.013432185,0.017750844,-0.09925113,-0.01707704,-0.027095998,0.020216124,0.022502353,-0.025645908,0.012620171,0.011853299,-0.041863438,-0.08096491,0.061099645,0.054753974,0.035693392,0.006861582,-0.012563461,0.0570952,-0.02518596,-0.13244006,0.11645666,0.0415455,-0.022551654,0.087767154,-0.0072911605,-0.005125293,0.0013811879,-0.0521399,0.030588338,0.07905082,0.015250265,-0.109138414,-0.05270309,-0.0024698812,0.048213948,-0.0908678,0.039178755,0.099204116,-0.015772933,0.08713783,-0.037963703,-0.093872085,-0.012757332,-0.043943014,0.09735766,-0.048499208,-0.012519499,0.03187053,-0.026354233,0.015019497,-0.020953264,0.03156953,-0.12418075,-0.0077517317,0.07570783,0.02611778,-0.061918106,0.011707,-0.010606432,-0.0011153072,-2.976013e-33,0.021691773,-0.012211934,0.08775634,-0.069770195,0.00769623,0.012692787,0.02148556,0.017685357,-0.000303517,-0.014554328,0.11356861,-0.00035243118,-0.026849115,-0.040783025,0.045509107,0.019265225,0.04955851,0.11806833,0.05255797,-0.015882906,-0.09027819,0.0072057615,0.022395922,0.0056239967,0.034571093,0.030302066,0.03076364,0.050872464,0.060917027,0.010899944,-0.046602055,0.05370272,0.002841841,0.04525186,-0.11392071,-0.0035577556,-0.06048304,-0.045270827,0.0124195,-0.0127118835,0.018381653,0.008364956,-0.03472355,0.08719091,0.014952244,0.071700655,-0.011163259,0.102789596,0.04212093,-0.08310877,0.05872004,-0.01411505,-0.00654295,0.056059208,0.048726685,0.017082023,0.091696136,0.055234857,0.03994258,-0.010179914,0.01616639,-0.03163069,-0.02475861,0.04517541,0.045644775,0.03473865,-0.041360185,-0.0142379785,-0.02603739,-0.023898406,0.05821173,-0.0013335586,0.018255044,-0.02589845,-0.00905241,0.008339183,-0.028927526,-0.064626485,-0.007726954,-0.026348555,0.0039688083,0.020343255,-0.01025783,-0.004364428,0.04010108,-0.0477971,-0.015501015,0.09364961,-0.0055101556,0.022932902,-0.04644079,0.0033506202,0.029744837,0.0030633819,0.053970005,-3.9665803e-08,0.019135458,-0.091639526,-0.012278898,-0.10265011,0.004102866,0.059098605,0.0041105393,-0.048061747,0.038581736,0.016831635,0.060916755,-0.026858082,-0.039684545,0.002823615,-0.0037657681,0.08141487,-0.06554487,0.0370266,0.0052672257,-0.0380575,-0.07893783,0.085645206,-0.089746155,0.010339262,-0.022505846,-0.041269027,-0.0057152966,0.056050494,0.010088745,-0.06285667,0.01013043,-0.01145219,-0.044982567,-0.030787153,-0.089791,-0.01681324,0.0029247727,-0.017320063,0.030588659,0.038649745,0.039228905,-0.039834652,-0.05542474,-0.013094145,-0.04736248,-0.03330343,-0.006556803,-0.0042005014,-0.035848573,-0.023974787,0.05138889,0.0021543775,-0.045950998,-0.14598404,-0.12537807,0.008902391,-0.008589461,-0.06446953,-0.076022856,-0.043122105,0.034286838,-0.0358047,0.19903977,-0.0014320419 +3.4.24.59,A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family),384,1.0,-0.070967,-0.045178548,-0.049762446,-0.028085245,0.13913517,0.048410773,0.01230273,0.08241361,0.06502016,0.035550937,0.050116204,-0.017130975,-0.02459916,0.024949465,0.034930587,-0.003961841,-0.08761518,-0.026317155,0.012079853,-0.07781876,0.07516757,0.064360105,0.04946999,-0.062561,-0.016998239,-0.026313683,0.033925995,-0.08943012,0.105755635,-0.054379504,-0.029949948,-0.13050018,-0.009480935,0.0005419139,0.05114328,0.06490604,-0.011902242,-0.062290695,-0.0071258363,-0.07938243,0.12715074,0.02785954,-0.07434744,0.00083519507,-0.0071223765,0.029957768,0.070412755,0.07719245,-0.024529897,0.0133217815,-0.023486804,-0.07398932,-0.04024404,-0.0016426637,0.0038340637,0.13182823,0.018263202,-0.06756755,0.0085959425,0.030888442,0.018588042,0.03946553,-0.040024083,-0.023577517,0.017678484,-0.028859315,0.0070797787,0.03943976,0.01799074,-0.028050786,0.02175859,0.038420174,-0.07653733,0.119592935,0.033479325,0.05373424,-0.02896396,-0.024334222,-0.065249585,-0.0168645,-0.025857814,0.01861115,0.098262,0.060597632,0.040997226,-0.03080005,5.1595598e-05,0.047805935,-0.0045169396,-0.028244292,0.028405048,-0.06776504,-0.024490323,0.020391757,-0.09790478,0.0050044493,0.04435954,-0.0124040935,0.029164866,-0.0045387,0.010410347,0.002934209,-0.043055512,-0.03400038,-0.06602221,0.08018738,-0.014382711,0.010663404,-0.0035982972,0.035030942,0.021740742,-0.046042267,0.069380924,-0.03636111,0.004079112,0.06228871,-0.05940322,-0.0968547,0.035551086,-0.017896274,0.058628533,0.051738303,0.073200725,0.072799504,-0.040930625,0.06867043,-0.080007054,4.7741733e-33,0.068253316,0.010499479,0.053153984,-0.0041934475,-0.025090577,0.049803723,-0.02182668,-0.0011177766,0.039477292,-0.024183415,-0.04515778,-0.08442273,-0.029994866,-0.006824699,-0.0135755045,-0.03711888,-0.088011704,0.0701305,0.06398464,0.04409377,-0.10159142,0.06488417,-0.023527972,-0.043956067,0.06083336,0.006431998,-0.02385777,-0.012269119,0.081992924,0.0015973867,-0.027026664,-0.094283506,-0.09987013,-0.032589804,-0.049799304,-0.025174977,0.04695628,-0.08548404,-0.04111439,0.028348897,0.0042009684,-0.004006866,0.0151696,-0.088719256,0.06493435,-0.056922838,-0.006124688,0.027077453,-0.06114621,0.0066983798,-0.025764396,-0.056546755,0.062130895,-0.029973462,-0.03993778,0.035932098,-0.020401277,-0.021780865,0.109981336,0.043680478,0.11192805,-0.009683563,-0.027068997,0.06208619,0.013146897,0.042777304,-0.016746713,-0.046777744,-0.012554425,0.11476299,-0.02480275,-0.0013082738,0.027417332,-0.015168867,0.08306679,-0.06924137,-0.06585838,0.03401261,-0.01618703,-0.0011589265,0.032076553,0.055332724,-0.021110116,-0.021384683,-0.020145595,-0.065739766,0.01409855,0.018386064,-0.05638112,0.05690011,-0.019706644,-0.0026373952,-0.021080336,0.030448448,-0.1005183,-4.0286252e-33,0.03827337,-0.0360985,0.034010734,-0.06496563,-0.074136585,-0.014008325,-0.033049796,0.05549988,0.061764155,-0.031499717,0.0315316,-0.06286897,0.036947653,-0.064747244,0.0160982,-0.060340643,-0.07227549,0.07858424,0.01501799,-0.0012488752,-0.037753172,0.015129273,-0.03600679,0.03500291,0.07731234,0.021520762,-0.041465014,0.1148353,0.0053523686,0.047886785,-0.037698697,0.03634149,0.009627913,-0.017378652,-0.06427587,0.044138584,-0.0030156688,-0.033917334,0.037222132,0.00563658,0.027190337,0.06600871,0.01973572,0.015533744,-0.039871156,0.032352366,-0.090940304,-0.025664633,0.02268052,-0.062863156,0.040825333,-0.049038135,-0.019989341,-0.0422261,0.029489832,0.0058978144,0.01069253,0.053854886,0.03919371,-0.039257716,0.005924814,-0.028387113,0.015680354,-0.0014930345,0.07748479,0.041662715,-0.10478426,0.06233303,0.018156901,0.063736044,-0.06686507,0.016011143,-0.014442689,0.007613055,0.043984,0.018888941,-0.0444836,0.003266323,0.025078433,-0.010096716,-0.045958932,-0.062577635,-0.034446165,-0.046129253,-0.0135543225,-0.019786337,0.010325962,0.08303718,0.04305253,0.07913234,-0.042649657,-0.073792085,-0.007397163,0.17094141,0.02563343,-3.172809e-08,0.022502806,-0.052016016,0.03832673,0.0036687055,-0.10751203,-0.020189507,0.033544853,-0.01963475,-0.030748079,-0.0142952055,-0.014458704,0.03685366,-0.0023518354,0.054195717,0.031554453,0.08535976,-0.058641702,0.001599582,-0.007363069,-0.0066744243,0.0029599466,0.046811927,-0.01898995,0.07307255,0.008515028,-0.03795927,0.013416864,0.024343798,0.046377182,-0.019745836,0.00020273867,0.014689301,-0.045021165,-0.039295327,0.011861934,0.019196719,-0.061120037,-0.03168164,-0.02905421,-0.038315684,-0.024362247,0.0029944493,-0.09083572,-0.06764565,0.04424045,-0.03178106,0.042721383,0.043032307,-0.050111096,-0.039590653,-0.06448935,-0.013930435,-0.0003350061,-0.087629326,-0.09294108,-0.010204897,-0.020067517,-0.035046827,-0.04254326,-0.081686266,0.039713148,0.052565403,0.24635555,0.047087062 +3.4.24.60,"An endopeptidase of 100 kDa secreted from the skin of the amphibian, Xenopus laevis (Dactyletre du Cap). Resembles neprilysin in insensitivity to 1 muM captopril, but differs from it in being insensitive to thiorphan (1 muM) and unable to digest [Met5]enkephalin, [Leu5]enkephalin, oxytocin, and substance P-(7-11)-peptide. A similar endopeptidase is found in human neuroblastoma cells [2]",384,1.0,5.6015648e-05,-0.041617922,-0.06631768,-0.01207499,0.07455567,0.0355037,0.06506258,0.11553113,0.032436192,0.07106353,0.05975527,-0.07502474,-0.07738707,0.06488299,-0.05155327,0.039485723,-0.0205454,-0.017282546,-0.026856752,-0.0046447744,0.04279532,0.06297316,0.05315327,-0.03825851,0.007524837,-0.01765213,-0.048057742,-0.065455,-0.0014890509,-0.08157314,0.049382675,-0.13772687,-0.06464733,0.00911578,0.047933057,0.04864099,-0.06200239,-0.009911885,0.06406638,-0.009979407,0.07577959,-0.0006160403,-0.15018095,0.034706477,-0.025391523,0.02217814,-0.07594313,0.051807947,0.023528086,0.07043485,-0.0077422555,-0.09662106,0.013797876,0.03310693,-0.032375142,0.017417036,-0.06493234,-0.03197794,0.0020988313,0.08310482,0.01607438,-0.0017307315,0.04593875,-0.028913321,0.016095078,-0.07038118,0.053116195,-0.061092936,0.05584766,0.029436383,0.057701748,-0.052355647,0.0070101963,0.0014245389,6.1463346e-05,0.061104357,-0.048807364,-0.061102588,-0.049348284,-0.055971436,0.03128467,0.064963,0.06488018,0.10399199,0.05061574,-0.037253823,-0.029489826,0.05942515,-0.06445083,0.02416929,0.005021672,-0.061878424,0.01570494,-0.035566755,0.062683344,-0.04772917,0.013974301,-0.0013371109,-0.07262947,-0.0066593746,-0.07871348,-0.034160357,-0.095268995,-0.07810464,0.035971347,-0.031131638,-0.02252371,-0.045771673,0.021805126,-0.053877365,-0.011193587,-0.041365728,-0.00022317133,0.005482269,0.0709457,0.008211673,0.030959193,-0.02397826,-0.04088621,-0.03524715,0.0121341385,-0.025380155,0.000763771,0.035039175,-0.024167608,0.058020826,-0.09714631,3.4105216e-33,0.017908666,0.035362653,-0.00039189227,-0.027042186,0.012248639,0.059659228,0.0015266689,0.06796639,-0.004772052,0.05917837,-0.06688656,-0.08773074,-0.023780046,0.05680368,-0.021153077,0.037876856,-0.043922782,0.02063354,0.05678023,-0.024926025,0.046014745,0.029549353,0.0027560182,-0.04894384,-0.007748863,0.025623037,-0.120877236,-0.0041195047,0.10269332,0.0041871327,0.017626407,-0.055618275,-0.016060876,0.05709901,0.0048536826,-0.014307684,0.073932156,-0.11264928,0.014584704,-0.03075878,-0.003507711,-0.011916104,-0.024352744,-0.060807765,0.031954363,-0.058637183,-0.04795348,0.012004879,0.060549784,-0.03759313,0.03394928,-0.03405308,0.08731479,-0.04238906,-0.044695716,-0.009245761,-0.047254186,0.030914098,0.033027466,0.040778745,-0.0012579969,-0.011740362,-0.016645165,-0.08386681,0.040721755,-0.037437856,-0.043942157,-0.02086992,-0.04876553,-0.019247094,-0.0341368,-0.013221763,-0.0087667145,-0.0071160663,0.026049262,0.017113168,-0.034374285,0.099021725,0.0140521685,-0.019874169,0.0926496,0.050602518,-0.020281477,0.013640622,0.012478232,0.0034414486,0.07386403,-0.011178966,0.007175575,0.06498397,0.060337137,-0.027348852,-0.05976854,-0.009750308,-0.069644004,-3.566698e-33,0.013597307,-0.017919904,-0.06466227,0.027179366,-0.023044856,0.073479846,-0.017737627,0.08728755,-0.008834923,-0.0027020262,0.09914342,-0.006626869,0.085482836,-0.044280123,-0.030028164,-0.012625246,0.023439012,0.07136145,0.086620115,-0.16475014,-0.08305618,0.0151992105,-0.011765542,0.007742759,0.12849244,0.060058076,-0.028708134,0.01291784,-0.034111466,0.06388966,-0.027174309,0.06818741,-0.008456978,-0.06814779,-0.0074798553,-0.022646967,-0.123506844,-0.060840543,0.02852033,-0.0115038315,0.016539762,-0.041936222,0.116992205,0.061484054,0.058249798,0.0145529825,-0.036347117,0.023259662,0.036809318,-0.028992021,0.034157608,-0.070696004,-0.020960782,-0.040019505,-0.009742719,0.025504136,-0.026112566,0.028578844,0.036975436,-0.030953811,0.038334914,-0.024043582,0.006580167,0.040665686,0.04171062,0.023596644,-0.014902145,0.04159252,0.031112699,-0.06456573,0.07660214,-0.024141543,0.0026402848,-0.015454925,-0.0473734,0.0068545947,-0.04666867,0.01889803,0.107128344,-0.012363486,-0.0597551,-0.012824483,-0.006645625,-0.026105493,0.080175966,0.008394683,-0.043416165,0.13203272,-0.050634943,0.01720007,-0.051264573,-0.016313458,-0.04906848,0.04024029,0.06278547,-4.5113616e-08,0.13217872,-0.016748024,0.079983965,-0.118023045,-0.0058067245,-0.06428987,0.060309727,-0.009373341,-0.0093035605,-0.0022392885,0.04184432,-0.0063516777,0.008279472,0.018165695,-0.014569398,0.029031845,0.065105915,0.08873367,0.013446675,-0.057709843,-0.0856001,0.0039878436,-0.049855083,-0.04778118,0.017409815,-0.058963656,0.03030285,0.072256856,0.017367845,-0.020924876,-0.005105229,-0.013085062,-0.01819862,-0.0319905,0.026955992,0.11324195,-0.06435087,-0.028793307,0.0228036,-0.019310944,-0.038400326,-0.0091871405,-0.013000445,0.017516319,-0.047121868,-0.022287983,0.14989091,-0.012444318,-0.030158658,-0.05111926,-0.0049670073,-0.050499573,-0.0010485274,-0.009606406,-0.11169819,-0.0062120864,-0.042005815,-0.05631501,-0.021882055,-0.06993241,-0.020272553,0.05181803,0.16034287,0.06323152 +3.4.24.61,"Enzyme of 133 kDa from rat brain and testis. A homologue of pitrilysin containing the His-Phe-Leu-Glu-His zinc-binding sequence, and a highly acidic stretch of 71 residues. Unusually for a metalloendopeptidase, inhibited by bestatin, amastatin and N-ethylmaleimide. In peptidase family M16 (pitrilysin family)",384,0.99999994,-0.02976798,-0.023049064,-0.09011473,0.0032562756,0.012534982,0.07632619,-0.002289185,0.10891695,0.0082919635,0.03283227,0.015575644,0.0010638719,-0.025117964,0.07810772,-0.09462548,-0.05365745,-0.051095977,-0.027311524,-0.05562463,-0.09529259,0.049493033,0.008030255,0.007584195,-0.0778008,-0.0030220286,0.02271139,0.012240822,-0.031189285,0.056992374,-0.005637309,-0.017796243,-0.04882929,0.04889818,-0.01294057,0.08753601,-0.042613752,-0.0049853977,0.009530649,0.056733083,-0.00046836538,0.030605987,0.053153303,-0.06216693,-0.03473095,-0.047630373,-0.033928644,0.019251846,0.021296995,-0.003870647,0.063762315,-0.023371397,-0.06592649,0.028911885,0.015603133,0.0013426691,0.0072461083,-0.052797057,-0.043618213,0.081702515,0.07897593,0.022916974,0.011305063,-0.026440432,-0.0036096608,0.039622042,-0.0604491,-0.009944072,0.010913873,-0.033190157,0.005009757,0.0382587,-0.06368548,-0.023040397,0.040729035,0.0016466858,0.06489026,-0.043885544,-0.080893345,-0.025582751,-0.08503478,-0.005471977,0.0515995,0.094915144,0.017642954,0.06718163,0.058706142,0.027835466,0.13522543,-0.0248875,-0.019994615,0.022257734,-0.113462284,-0.04550321,0.005913431,0.002118128,0.072861545,-0.012478285,0.02480784,-0.02869896,0.02619488,0.080344655,0.03987281,-0.008900771,-0.05184255,-0.018135853,0.07008314,0.029944897,0.03714358,0.08094137,-0.015205649,-0.06797479,-0.0026594596,0.021607295,0.029280065,0.016303914,-0.009964832,0.03960567,0.0160629,-0.05481788,0.0074091703,0.06842688,0.031079434,0.006888428,0.04073251,0.01575751,0.044718612,-0.09921311,2.0464874e-33,0.08455493,-0.008621486,0.04535063,-0.09297066,0.032293715,0.008883398,-0.036987267,0.040661916,0.02800454,0.060287286,-0.10138723,-0.076617174,-0.009238261,-0.02148653,-0.11964237,-0.0014890047,-0.029515332,-0.051386237,0.068112746,-0.0060990877,0.0036723777,0.057307273,-0.05347571,-0.04493099,0.023711966,0.021451438,-0.008063851,0.04884711,0.0978383,0.0072146305,-0.05502162,-0.10093763,-0.078093864,-0.041676197,0.053519566,-0.07140688,0.031917617,-0.06144955,-0.0070654103,-0.0018419371,0.04375224,-0.014092734,-0.059724357,0.05804727,0.029115325,-0.059700716,-0.095371075,0.035288837,0.023787834,-0.03316371,-0.005783974,-0.031348217,0.09395694,-0.019800955,-0.09469058,0.028213745,-0.029819245,0.022359459,0.08104049,0.087438576,0.031301584,-0.00013685081,-0.055684008,0.071800165,0.02039596,-0.028755032,-0.16923457,-0.055671286,-0.08005179,0.06360754,-0.08315092,-0.024787536,0.036703758,-0.03844384,0.06312434,-0.119685225,-0.016627915,0.113879524,-0.065045,-0.03312326,0.024324618,-0.015396994,-0.01077965,-0.0028315294,-0.038243767,-0.046335205,-0.02722618,-0.028738722,-0.03895349,-0.037950844,0.069232576,-0.001834121,-0.031213341,0.016745381,-0.016895613,-2.8985417e-33,0.069499165,0.030263701,0.12593082,-0.015931517,-0.029889617,0.014592872,3.953197e-05,-0.025728704,-0.036400583,-0.07474975,0.07400744,0.013405809,0.085320145,-0.074236415,-0.0006227587,0.039207585,-0.019726092,0.08028068,0.03130364,-0.08934478,-0.09144845,0.03573403,-0.0022697514,-0.0376606,0.034549393,0.014210065,0.0026967344,0.067579426,-0.0060126204,0.109811395,0.0067233047,0.08207178,-0.079781815,-0.0886136,-0.0404988,-0.0061373105,-0.021187797,-0.07817215,-0.058271304,-0.016753145,-0.018495822,0.064751364,0.062236663,0.10917822,0.09096691,0.08510405,-0.06511342,-0.0028986514,-0.0050354353,-0.10305469,-0.014710021,-0.0016551329,-0.007108103,-0.017452499,0.11171375,-0.028542269,0.0015251683,0.03420466,0.001210816,-0.041153766,0.0073048943,-0.027260913,-0.0044013634,0.05240527,0.08312849,0.014755823,-0.03896044,0.11080082,0.05299364,0.03696425,0.02546916,0.004741342,-0.006355796,0.030412387,-0.0154914325,0.065171346,-0.026481401,-0.06598785,0.008542308,-0.02680481,-0.038963575,0.015133193,-0.064292066,-0.059617054,0.016199855,-0.04222759,0.022954924,0.11456463,-0.03186053,0.00033881355,-0.038992908,-0.054976955,-0.004704875,0.01295989,0.008252262,-4.3517048e-08,-0.0017671583,-0.07210385,-0.0041584307,-0.058286104,-0.061375905,-0.050486244,0.024405094,0.050945193,0.03209099,-0.021445386,0.046832822,-0.0012771004,0.021502202,0.05084692,-0.0013271488,0.046110477,-0.0002882325,0.056233257,0.039163895,0.03532772,-0.044978965,0.050367698,0.001975002,0.05409471,-0.008412658,-0.034319747,0.099886246,0.10923381,-0.061268926,0.00857092,-0.021933936,-0.001308226,-0.015498165,-0.02756728,-0.035132382,0.0229866,-0.05340969,0.043984767,-0.015109951,-0.032223895,0.030071024,-0.012593867,-0.03922693,-0.021396624,-0.034272853,-0.053897366,0.057151154,0.062022828,0.008117294,-0.11643922,-0.028000124,0.017717142,-0.03117074,-0.05006599,-0.0022319409,-0.0006193932,-0.031966355,-0.044689618,-0.035106994,-0.08011156,0.007644146,0.039911207,0.15316139,-0.0053008576 +3.4.24.62,"An endopeptidase of 58 kDa known from bovine pituitary neurosecretory granules and bovine and human corpus luteum [4,5]. Inhibited by EDTA [1]",384,1.0,0.026337784,-0.046619203,-0.043973286,0.040531218,0.03150673,0.060778737,0.105976745,0.050909806,0.016823858,0.108389,0.03497819,-0.047245517,-0.14315824,0.06417689,-0.02717287,0.04580327,0.0034138735,-0.064228244,-0.014697054,-0.035749007,0.08323074,0.037554447,0.013042183,-0.041385338,0.007322479,-0.025371531,-0.011814444,-0.07426024,-0.06673573,-0.03666098,0.015982984,-0.08972411,0.044457447,-0.011936081,0.042774353,-0.04555341,-0.048021704,-0.017797755,0.014158798,0.023878807,0.091439426,-0.022338057,-0.04609357,0.054714918,0.014568918,0.037576206,-0.04112627,0.0315925,0.012796627,0.044262215,0.07248043,-0.13121673,0.029187122,0.03585217,-6.907758e-05,0.034468867,-0.0187066,0.021514766,0.035942055,0.099143386,0.04420749,0.047348835,0.023887428,-0.016514337,0.09471041,-0.08656844,0.054029018,-0.036741853,-0.015311173,-0.046061847,0.08315103,-0.08667935,-0.040581215,0.042415507,-0.0017726872,0.042496663,-0.062334895,-0.03034952,0.019554613,-0.06836657,0.057700817,0.058686726,0.076716654,0.009134434,0.032212812,0.007531179,0.021843828,0.104714975,-0.029730106,-0.06351509,-0.012659897,-0.12643814,-0.039883036,-0.038513158,0.06875595,-0.021921193,-0.034291085,-0.027282063,-0.045956023,-0.035774723,-0.046712786,-0.00095396524,-0.05718815,-0.10768084,-0.06528083,0.058793586,-0.018396586,0.026347198,0.06322153,-0.04093717,-0.021194998,-0.023216972,0.029545315,0.027948037,0.11063518,0.0043010223,0.0045818575,0.0034130933,-0.015989365,0.011957204,0.036142066,0.0073183323,0.03247571,0.064723305,-0.016070124,0.054259907,-0.011849547,1.3904508e-33,0.059127867,-0.05839816,-0.03967778,-0.026473027,0.04017758,0.037894845,0.02568077,0.02536982,-0.01636142,0.030241119,-0.09341747,-0.041371807,0.029393569,0.029678198,-0.047854222,0.015222414,0.029461598,0.00095692725,0.091004245,-0.021504426,0.04580715,0.04464887,0.013791543,-0.027481234,-0.018588189,0.049447484,-0.08597114,0.021648929,0.12378023,0.008657771,-0.01966504,-0.11649542,0.0036467211,0.05096528,-0.015464715,-0.027462564,0.03245605,-0.0995547,0.021126714,-0.030667722,0.062115457,-0.01707662,-0.021256417,0.013842603,0.0022391062,-0.01522515,-0.024635771,-0.021588048,0.030393092,-0.02588323,0.012360297,-0.02032446,0.047130384,-0.024934342,-0.037378475,0.054929927,-0.033975422,0.00017290884,0.06551703,0.011253064,-0.0040414943,0.04251806,-0.10008049,-0.04202025,0.023088193,-0.038271043,-0.07153291,-0.042777088,-0.059401188,-0.0058573703,-0.05582042,-0.046033345,0.036564305,-0.029703114,0.03437813,-0.05326632,-0.061065834,0.07287643,-0.06145549,-0.008957012,0.075625256,0.013010951,-0.022086259,0.0021332526,0.039763246,0.035381652,-0.0017704809,0.02304571,-0.014106411,0.015947977,0.014684691,0.0098021915,-0.042862564,-0.0022089535,0.0056918613,-7.62436e-34,0.028429942,-0.036000974,-0.05661041,0.015787715,0.012197791,0.08977862,0.026026191,0.02212145,-0.015641468,-0.041217282,0.13189144,-0.075377,0.07173689,-0.028483283,0.044166487,0.015241997,-0.059524737,0.07840296,0.038377155,-0.088593386,-0.046352904,-0.042559337,-0.019408885,-0.0050019217,0.14998937,0.022214273,-0.057245877,0.03282245,-0.0036570157,0.047767054,-0.021693936,0.007979479,-0.018362217,-0.07440416,-0.002744271,-0.01773249,-0.058381107,-0.054311942,0.01720103,-0.02417888,-0.00810681,0.0021156026,0.072799355,0.030728837,0.05980182,0.03232911,-0.08383885,0.07378381,0.017702153,-0.06969121,-0.0015334368,-0.048858553,-0.058677085,-0.087097995,0.0028504974,0.004796892,0.03312028,0.014957609,0.013274158,-0.03090173,0.030114306,-0.03156646,0.10329608,0.011813665,0.08364921,0.043152556,-0.016922936,0.09891071,-0.021639813,-0.017299406,0.040775623,-0.045864128,0.010211019,0.026224354,-0.040649135,-0.00013179841,-0.028765809,0.041169543,0.12189081,-0.023981586,-0.0022672697,-0.052888907,-0.03589565,0.019911196,0.1062317,-0.014295711,-0.04098892,0.09393968,-0.0043143914,0.046268273,-0.108478144,-0.050551288,-0.023612138,0.011440784,0.08759632,-3.0528412e-08,0.085794345,-0.05655631,0.02788027,-0.11218785,0.036204197,-0.039740883,0.04359408,0.025615651,0.056714896,-0.10512455,0.03962082,-0.009183503,0.021019597,0.074643165,0.0046953894,0.04274068,0.062224172,0.06258201,0.05703388,-0.031861987,-0.022679161,-0.024001764,-0.04971061,-0.07729631,-0.036186896,-0.039325356,0.04376074,0.14062953,-0.006448693,-0.04465537,-0.0034291705,-0.010008435,-0.042766545,-0.004442874,0.042941976,0.12883878,-0.04784077,0.011488671,-0.019499509,0.033210516,-0.033485483,-0.009713174,0.016599094,-0.031974018,-0.0012336713,-0.03971665,0.11769498,0.0068721306,-0.045428548,-0.08856212,-0.049017403,-0.058877368,-0.025529416,0.0139359515,-0.07388508,-0.06564513,-0.046533346,-0.11056114,0.001123131,-0.05527983,-0.038374756,0.02717642,0.10752589,0.034414086 +3.4.24.63,"A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)",384,0.99999994,-0.049716737,-0.056568187,-0.056494787,-0.014892177,0.06321782,-0.020526286,0.08087976,0.12621287,0.030322846,0.003903191,0.023983799,-0.022372924,-0.03226904,0.10763279,-0.11214505,-0.07417085,-0.0059551955,-0.015719073,-0.05505081,-0.03896662,0.047529288,0.01638235,-0.015590979,-0.061033048,-0.041564032,-0.053038694,-0.0012943292,-0.028071675,0.06147571,-0.04383734,-0.04180796,-0.036576547,-0.028469104,-0.010786386,0.068662725,0.0017314567,-0.010097463,0.00423337,0.014014507,-0.06123271,0.06982534,-0.017028155,-0.01562612,-0.0038683687,-0.039685138,-0.010372727,-0.031997547,0.07144074,0.031288397,0.09191597,-0.035045467,-0.050782636,0.013756513,0.07911035,0.012480774,0.052564956,0.012240895,-0.017649505,0.083371736,-0.002710911,0.018389445,-0.03581834,0.08005056,-0.013708483,-0.033214528,0.023404801,-0.035552576,0.036942877,0.02498782,-0.0581583,0.020657947,-0.020150535,-0.04776562,0.08911797,0.05128343,0.052105,0.009719646,-0.023101747,-0.059053447,-0.057845507,0.017899461,-0.015400706,0.010590008,0.030580826,0.06396622,-0.0063400427,0.031782012,-0.007865025,0.012595636,0.049701598,0.008990576,-0.042247195,-0.007787159,-0.0100128325,-0.039755862,0.013129292,0.037852567,-0.07857165,-0.0369568,0.01234837,0.0022547618,0.039581574,-0.007495777,-0.06245247,0.016884465,0.0015252276,-0.049492866,0.0004983244,0.09602583,-0.016471848,-0.009560726,-0.041863978,0.02372799,0.02660014,0.08129982,-0.05666388,0.055865116,-0.018151699,-0.013889193,0.012088391,0.0373241,0.029505286,-0.035847176,0.019365652,0.02769369,0.049272154,-0.10416723,3.6444494e-33,0.03975223,-0.035126932,-0.015192323,0.041690577,0.0262143,-0.023921734,-0.010742293,-0.016242094,0.0097790025,-0.07958956,-0.12457407,-0.18141924,-0.056100123,-0.028795822,-0.018848326,-0.012682919,-0.07205809,-0.025905946,0.08480145,0.018552441,-0.04354899,0.094998084,-0.02888827,-0.10088413,0.11434191,0.002435987,-0.08910311,0.026688965,0.09357633,-0.0012597681,0.028718079,-0.052758846,-0.1376416,0.016843159,0.01574199,-0.07327036,0.045319807,-0.10462477,-0.007013841,-0.025898604,-0.035999656,0.028907206,-0.021516751,-0.056940835,0.15959749,-0.11628113,-0.05721957,0.05275866,0.0052117677,0.0140020745,0.050095614,0.008765517,0.13120784,-0.06975386,-0.090030074,-0.05138355,-0.06655425,0.022341434,0.07983754,0.08131791,0.047233477,0.060556754,-0.042191815,0.06561589,0.048282787,0.020584706,-0.0728005,-0.041578114,0.0032915936,0.00912432,-0.068176374,-0.041264102,0.03346769,-0.018135214,0.023948558,-0.061390445,-0.021027584,0.12143278,0.04580013,-0.022646869,0.033459324,0.07891891,-0.012605742,0.058906063,-0.024020132,0.020285072,0.034277543,-0.055520624,0.016903624,-0.05976135,0.062118035,0.001223597,-0.14223155,0.057519738,-0.034824137,-4.7071055e-33,0.090038195,-0.016472736,0.12288568,-0.0010006584,-0.08747749,0.06394723,-0.028828323,-0.009966939,0.013907296,-0.066518456,0.06805304,0.01472512,0.012934828,-0.058963567,0.032268163,-0.023039687,0.02026961,0.050623633,0.017933019,-0.06855841,-0.06164175,-0.01243495,0.06068244,0.045514714,-0.004242089,0.0056273574,-0.03360052,0.033170942,0.0023754342,0.040189687,0.05226049,0.05820105,-0.0775933,-0.14104818,-0.057550922,-0.06925158,-0.09511355,-0.020940134,0.010225758,-0.010945512,0.042135395,0.007139039,0.07062025,0.0026048427,-0.061546925,0.092504084,-0.010630318,0.014608159,-0.019281106,-0.018915256,-0.0286832,-0.05916163,-0.014720265,0.009491468,0.06803915,-0.024238555,0.06739862,0.0121308165,0.059026625,0.036457423,-0.01778084,0.06872742,-0.007166356,0.011805804,0.036768608,0.020115238,0.0033218223,0.026862234,0.08033666,-0.00791904,0.11443807,0.012409869,0.05644414,-0.047044996,0.0316359,0.0014506838,0.018225014,-0.030872744,0.016189601,-0.07143457,-0.064945646,0.0084012905,-0.0054889754,-0.041078933,-0.019715369,-0.04472606,0.0034828533,0.10271968,0.06942664,-0.008048656,0.01501249,0.01119581,-0.03727434,-0.001584566,0.06185817,-4.6028006e-08,0.086268716,-0.0067880554,0.037219524,-0.10835408,-0.043664873,-0.06350261,0.007432829,0.042911045,-0.00564541,0.033982314,0.045213398,-0.01056516,-0.0037358755,-0.04365168,-0.03397698,0.11512375,-0.033566773,-0.0009960711,0.014879466,0.009480836,-0.07606595,-0.040329088,-0.039169446,0.023947977,0.057652596,-0.084940284,0.03237939,0.05820973,-0.039132327,-0.030382354,-0.028599584,0.022692954,-0.019387491,-0.014256534,-0.0014849684,0.040866517,-0.0014163264,0.01520432,-0.006196839,-0.029815909,-0.026619243,-0.049302325,0.03869485,-0.035863526,-0.0424873,0.00023207148,0.046131235,0.068637185,-0.016405435,-0.07663137,-0.018118659,-0.007128337,0.015248634,-0.04488198,-0.07271514,0.0005480764,-0.01630879,-0.053995103,0.016394032,-0.032095294,0.037045576,0.053719528,0.08713343,0.031944174 +3.4.24.64,"Known from the mitochondrial matrix of fungi and mammals. Formed from two subunits, both homologous with pitrilysin [3], and the products of the MAS1 and MAS2 genes in yeast. In peptidase family M16 (pitrilysin family).",384,1.0,-0.058904797,-0.008220593,-0.10338275,0.0007673916,0.020778043,-0.012680057,-0.046634343,0.013254609,0.054215793,-0.040289763,0.16025038,-0.04605483,-0.036437888,0.0010512957,-0.07879041,-0.004481814,-0.09573443,0.020635113,0.03847059,-0.045779996,0.07398939,0.04739459,0.03995918,-0.042512514,0.01636553,0.0067689368,0.019357834,0.022445807,0.056058854,-0.106656976,-0.012936117,-0.0090641305,0.068916254,-0.04061333,0.058260314,0.014957015,0.086932085,0.03259119,0.08362043,0.036170855,0.048045572,-0.0058261147,0.034784023,-0.019525481,0.017813865,0.04931673,0.014543781,0.06423918,0.059824947,0.019048363,-0.032336637,-0.028411338,0.0073660067,0.06477613,0.018554822,0.014645906,-0.041677155,-0.037490662,0.02127866,0.054072462,0.015812056,0.04083968,-0.07483078,-0.046012342,0.0076820366,-0.03622355,0.04211323,-0.02575048,-0.0024861086,0.030747328,0.046986144,-0.078752816,-0.008306049,0.0784254,-0.047492217,0.1347393,-0.035087213,-0.08830647,-0.013497599,-0.012324906,-0.024785746,0.064840004,0.07174755,0.013155725,-0.039757885,-0.026825072,0.021704797,0.064018026,-0.014709296,-0.056235448,-0.04810556,-0.08204692,0.0027613628,0.026017692,-0.03922539,0.106024906,0.059767302,0.10338129,0.032112326,-0.024466403,0.040245906,-0.020656971,0.021891,0.00092514715,-0.025266541,0.05074403,-0.05752307,0.08781181,0.06739131,0.006683865,-0.014249526,0.014459104,-0.025872072,-0.0626014,0.008425326,-0.009666535,0.041586366,-0.005232186,-0.007531132,-0.012109875,0.04006788,0.11493522,-0.008028602,0.003361438,0.013917503,0.031471085,-0.1156686,3.7824708e-34,0.022267371,0.04000598,0.026823916,0.049056657,-0.017607538,-0.04472257,-0.059534635,-0.043807223,-0.0066172997,-0.04483095,-0.10240159,-0.0073854667,-0.07986972,-0.016445752,-0.077366516,-0.0074001933,0.023854265,-0.0754609,0.07439427,-0.031809635,-0.072948255,0.15862808,-0.028683921,-0.09869326,0.07136425,0.011763715,0.08871533,-0.07208609,0.062054586,0.0021418612,0.012656575,-0.07946935,-0.041836184,-0.01857726,0.0021545435,0.0029516055,0.0042243446,-0.07003165,-0.018025117,0.049145672,0.012741171,0.012940293,-0.025569744,-0.05240197,-0.004210974,-0.084835105,-0.013700136,-0.012195711,0.0035490368,0.020521894,-0.016350588,-0.017637929,0.08154245,0.042808518,-0.07821544,-0.027143335,-0.024093049,0.024083583,0.039711576,0.072958484,0.0137298815,0.025873201,0.003648586,0.08623292,0.044993404,-0.027346376,-0.10736036,0.0052304366,-0.019956117,0.11614871,-0.049021665,-0.020554326,0.012292815,-0.033748724,0.036143064,-0.043990612,-0.018841274,0.03287986,-0.08453773,0.026276514,-0.02027922,0.008728592,-0.02946772,-0.00325906,-0.09372313,0.01259296,-0.0074635423,-0.013150362,-0.09105235,0.025297966,0.017582528,-0.00033974246,0.007260825,0.034968257,-0.027535012,-2.1890622e-33,0.0783037,-0.013277307,0.13576049,-0.0942489,-0.10476866,0.07295841,0.013181844,-0.033368498,-0.0854014,-0.039631825,0.004930217,-0.032269537,-0.0010906404,-0.11244629,0.04455568,-0.012829434,0.0359145,0.080101445,-0.01407957,-0.027923316,-0.039632235,0.10666611,-0.06968087,0.029854637,0.049879815,-0.018921817,0.078759134,0.094639875,-0.020332815,0.0058824,-0.008733427,0.008835981,0.0045378217,-0.05603976,-0.02032669,0.026886512,-0.035328764,0.024409916,-0.01747576,-0.02679318,-0.016203446,0.09462333,-0.00028549708,0.06872333,0.03408151,0.054653235,0.0014950618,0.030709993,0.061368525,-0.08835627,0.010077136,-0.05017335,-0.03737635,-0.03697845,0.058176573,-0.07976854,-0.060763035,0.050190967,0.031936273,0.005801909,-0.03310393,-0.011706213,-0.012469838,-0.042728703,0.08656875,0.051307824,-0.13653468,-0.047674377,0.028425267,0.06245642,0.045392774,0.005223424,0.00047521916,0.03721155,0.036485128,0.055048466,-0.09785519,-0.033378378,-0.025132088,-0.056990907,-0.015901303,-0.06493051,-0.011493637,0.01020303,-0.004716573,-0.120799884,0.027429635,0.10123235,0.030433884,0.030375717,0.013357007,-0.018038323,-0.04678796,0.063635856,0.027697286,-3.2660992e-08,0.024071075,-0.0058672577,0.048765756,-0.05452807,-0.07692625,0.06700542,0.030607717,0.060251724,0.070038415,0.0449443,-0.0086160805,0.045905206,0.010670352,0.012839646,0.0047995704,0.0354825,-0.054490026,0.047006287,0.016823854,-0.0025551238,-0.030876005,-0.015619051,-0.0405019,0.07932843,-0.057645984,-0.024318988,0.0439416,0.033497065,0.023297511,-0.04225351,0.029367507,0.0019632801,-0.025277253,-0.070700765,-0.009928548,0.02090995,-0.06337531,-0.023127532,0.008849277,-0.03690773,0.056296986,-0.03226073,-0.06653402,0.009448695,-0.033131983,-0.054302823,-0.011830944,0.07979955,-0.040393416,-0.025516722,0.01964939,0.019214429,-0.0064096716,-0.04559345,-0.14360201,-0.066056624,0.013709414,-0.03946099,0.02617257,-0.073099084,0.035320826,-0.021634987,0.1387535,0.032345 +3.4.24.65,This enzyme is synthesized as a proenzyme of 53 kDa that is converted to an active form of 22 kDa. cDNA sequences have been obtained for the mouse [3] and human [4] enzymes. In peptidase family M10 (interstitial collagenase family),384,1.0,-0.029527586,-0.050912697,-0.09728621,-0.12130435,-0.057928544,0.005785322,-0.03922979,0.022038272,-0.040668223,0.06414939,0.018234612,0.00035663042,-0.057902966,0.040709913,-0.06224933,-0.0066002454,-0.121850684,-0.055960435,0.007675144,-0.05515523,0.022367602,0.0625479,-0.032880776,-0.047790837,-0.026618212,-0.04097065,0.13718292,-0.072358996,0.017253615,-0.028397774,0.014242405,-0.076234624,0.082893044,-0.03988528,0.10451533,-0.06532006,-0.09579314,-0.030525275,0.0340414,0.025780259,0.08088987,-0.02354969,-0.021982804,-0.05077068,0.02942609,-0.06093714,0.039374948,0.0103740785,0.053870138,0.04048825,-0.01850206,-0.05315055,-0.055153966,0.04932049,0.017859347,0.025482014,-0.10289227,-0.022156078,0.053449545,0.074232996,0.020040475,0.02060041,-0.013392047,-0.04363353,0.054411624,-0.08051194,0.071781576,0.009945125,-0.027974494,-0.018529268,0.0014102244,-0.046239898,-0.025773928,0.09527251,-0.031724982,0.0022210956,-0.018724533,-0.021153916,0.0026554242,-0.02845949,-0.009100385,0.007986005,0.06555276,0.015319559,0.014336906,0.022504238,0.02228615,0.076243125,0.012213902,-0.052706786,0.028818447,-0.040841583,-0.0050171507,0.008419778,-0.034524407,0.1025144,0.05296935,0.030617852,0.06757304,-0.0044233906,0.027160687,0.028077563,-0.000378434,-0.10529567,-0.071161665,0.050267566,-0.01723291,0.09646079,0.00786745,0.042422034,-0.0049757482,0.011998376,-0.039568033,-0.023729306,-0.008198443,0.013816898,0.009185344,-0.024841046,0.057331193,-0.020869246,0.02047438,-0.0020708854,0.062286668,0.05578783,-0.07851298,0.043651003,-0.060181882,1.8420707e-33,-0.012981401,-0.030162498,0.027999114,0.022978049,-0.01772822,-0.04566638,-0.021934275,-0.013845399,-0.06803674,-0.054404784,-0.079353735,-0.032417666,0.0038745683,-0.050862797,-0.078617364,0.04737279,-0.035353046,-0.025969343,0.03651027,0.041397717,0.015680667,0.11088519,-0.0153441895,0.016580526,0.08074859,0.023993906,0.019620601,-0.007825541,0.09822548,-0.0042398563,-0.06086488,-0.071357176,-0.08794586,-0.033364244,-0.0029724604,-0.030883452,-0.0068602557,-0.04750437,-0.0063969824,0.06329435,0.025314968,-0.035948563,0.023109311,-0.06330856,0.058661286,0.023326611,-0.022950351,0.03996617,-0.028976163,0.015739176,0.033943444,-0.010063486,0.05838839,0.019954735,-0.081284456,0.0152769005,-0.013840222,-0.024476828,0.14163405,0.047183365,0.013110128,0.0017198654,-0.0072522126,0.091589674,0.0032644847,0.012215064,-0.10582553,0.023094699,-0.019997615,0.08072015,-0.059323832,-0.03722472,0.027686192,-0.043197222,0.07732152,-0.112518944,-0.0064210575,0.057589483,-0.088641554,0.059014354,0.029204048,0.060565174,-0.03309626,0.038952652,0.0013883945,-0.07192496,-0.026882788,-0.011300862,-0.04146596,0.072776094,0.100704476,-0.028900217,-0.057203785,0.09267479,0.00028947231,-3.5469032e-33,0.09520507,-0.06643269,0.076899976,-0.053713314,-0.0547188,0.048011318,0.10933936,0.03273125,0.0037048114,-0.02028744,0.043664426,0.0013707818,-0.0024170885,-0.05066802,0.026542323,0.053921968,0.027705844,0.043336038,-0.061053105,-0.009411839,-0.014108104,0.08910013,0.016041134,0.010109531,0.040231306,-0.019600205,0.0053694476,0.089458875,0.0044105635,0.021009536,-0.037399497,-0.016019246,-0.030854499,0.023623414,-0.09034998,-0.010972332,0.021771496,-0.039173402,-0.02806755,-0.029782483,-0.012298805,0.11705712,-0.014849113,0.098327935,-0.017849036,0.049539823,-0.0041511348,0.02011132,-0.027757542,-0.074347764,0.05339169,-0.01678006,0.0030765235,-0.041933525,0.058188803,-0.04021099,0.059457544,0.044508107,0.04683294,0.0087013105,-0.020943442,-0.07466821,0.049440585,0.012706468,0.0698094,0.03270303,-0.117413424,0.046640538,-0.036844254,0.03292381,0.03749577,-0.022723602,-0.006558035,0.03128179,0.01070088,0.0203017,-0.005362382,-0.023541393,-0.018610109,-0.08024935,-0.009257107,-0.066698074,-0.01925741,-0.0041658967,-0.011224543,-0.031121098,0.09112507,0.12288222,0.051226437,0.05393366,-0.0009780095,-0.008821296,-0.042672165,0.071230866,0.031089012,-3.454018e-08,-0.0033426664,-0.1044516,-0.027019085,-0.08987693,-0.019759445,0.0076995175,-0.010646623,0.023459027,0.08201219,-0.07060524,0.029135324,0.025324015,0.018960258,0.09332772,-0.0017264402,0.051425442,-0.025464874,0.024142832,0.0023289418,0.017739125,-0.057601392,0.03620308,-0.10036114,0.088765144,-0.004667174,-0.026799941,0.009046249,0.057690274,-0.0862058,-0.09866544,-0.049956754,-0.012655853,-0.044553164,0.015145435,-0.042700797,0.061404105,0.049111288,-0.010509873,-0.022648035,-0.03168793,0.034447838,-0.080596246,-0.04466799,-0.060200077,-0.052429423,-0.028176542,-0.036330298,0.049015258,0.011614802,-0.046690248,-0.049647365,-0.014957844,-0.029122146,-0.1306659,-0.053751245,0.013590185,-0.06862383,-0.051782016,-0.029093409,-0.07668574,0.06817279,0.013055271,0.1596615,0.007940113 +3.4.24.66,Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin H. A 24 kDa peptidase family M12 (astacin family),384,1.0,-0.04557663,-0.002232314,-0.06390218,-0.03647243,-0.1175996,0.005090829,0.030363966,0.037868187,0.015194512,-0.022203598,0.12474061,-0.004218203,-0.08933603,0.039940763,-0.05257423,0.01106605,0.013761006,-0.05443532,-0.07026481,-0.0017374955,0.020938544,0.009211636,0.02627141,-0.0035406037,-0.02685065,0.04519515,-0.032899532,-0.023714194,0.0330482,-0.079643205,-0.042260997,0.011767876,0.06669321,-0.060954824,0.043751616,-0.032302536,-0.012634128,-0.03425765,0.082990296,0.044360425,0.08901605,-0.0037568342,-0.05082085,0.0064978846,-0.024795674,-0.08098053,-0.012762096,-0.061762642,0.07689504,0.008267852,-0.10809225,0.004014448,-0.023860807,0.05377749,-0.017720753,0.09386556,-0.093660936,-0.06520523,0.0045092176,-0.0035008194,0.052651536,0.04950016,0.0040969797,-0.023096265,-0.050790884,-0.028447108,0.024803916,0.005654145,0.03954443,-0.010200723,0.045848656,-0.020729769,0.015469524,0.06071816,-0.02160931,0.052404303,0.009318819,-0.036541805,-0.04572214,-0.0131819695,-0.012791378,-0.0894897,-0.03427656,0.08638896,-0.04432078,-0.0025369944,0.079738855,0.04600211,0.029109422,-0.09319321,0.0018282456,-0.017187424,0.055758413,-0.049664907,0.005593562,-0.032740258,0.036696054,-0.0724287,-0.05876806,-0.0062717437,-0.008956369,-0.044664863,-0.048269164,-0.08540208,0.009220304,0.011414709,-0.031039512,-0.005580256,0.086337626,-0.0468676,-0.08543852,-0.06726405,0.024706243,0.0546608,-0.03652901,0.008078524,-0.047579497,0.01794375,0.06714703,-0.022480331,0.05793975,-0.049368747,-0.06257446,0.001324973,-0.009881027,0.087191954,-0.06301681,2.9502295e-33,0.0073683923,0.04872761,0.057144452,-0.007193598,0.05404133,-0.067078955,-0.049880676,-0.034644224,0.020420333,-0.07104036,-0.08214326,-0.012361589,-0.09597785,-0.002985395,-0.01926106,0.02147722,-0.013553565,-0.021712322,0.0035084335,0.038483858,-0.01769146,0.10850638,-0.030768555,-0.07014924,0.07328666,-0.024219112,-0.046726793,-0.055965845,0.0014926906,0.03395902,0.031810403,-0.10720032,-0.09227288,0.00382634,0.042694855,0.021790562,-0.003989479,-0.08155785,-0.026301123,0.03693313,-0.005828643,-0.06631505,0.014917373,0.04605273,0.054495115,-0.045179497,-0.05047089,0.109806046,0.045314103,0.0105294315,0.016886171,-0.05256327,0.015732849,-0.008229127,-0.049672935,0.010073518,-0.0127562145,-0.0018489354,-0.022725344,0.07078314,0.06051516,-0.03386001,-0.03746283,0.018773474,0.093022235,0.023872003,-0.07850818,0.014149423,-0.065811515,-0.04220729,-0.09709664,-0.03246072,-0.026928056,-0.001931146,-0.007945216,-0.05692811,0.046015464,0.048552316,0.004312032,0.002126238,0.08604513,0.044670384,0.067399085,-0.02747983,-0.08363067,0.0039842557,0.04859067,0.010028397,0.014787138,0.08257467,-0.013770064,-0.003556972,0.0053471075,-0.039185725,0.002111403,-4.1154472e-33,-0.01958556,-0.101544484,-0.004933268,-0.002629256,-0.010442251,0.05371838,0.076028205,0.11779006,0.03419904,-0.010739982,-0.009606861,0.006518107,0.037290294,-0.083699815,0.033666782,0.06646843,0.107660815,0.051458124,0.018195799,-0.08558207,-0.09076973,0.063677035,0.03272,0.15694015,-0.00825393,0.03125716,0.052385766,0.013842526,-0.050882436,0.043486696,0.004264143,-0.013185093,-0.021077115,-0.008090815,-0.031642728,0.050363045,-0.00026967714,-0.020960951,0.0223698,-0.0012977894,-0.029267035,0.0051261787,0.06369265,-0.004050585,-0.025754945,0.046415124,-0.005140556,0.025597913,-0.050799787,-0.014922507,0.042576127,-0.03335552,0.0033911099,-0.010231156,0.086374454,0.024876572,-0.02289003,-0.03569302,0.046092007,-0.044653118,0.042608887,-0.028739393,0.018621797,0.023832167,0.04220478,0.037155792,-0.05337627,0.0072438125,0.006335823,-0.022860402,0.0005638854,0.041091792,0.01445104,-0.019285921,-0.021702232,0.09736779,-0.122653544,-0.12295696,0.027103368,-0.02775524,-0.028490964,0.0037220484,-0.018553585,-0.023791915,-0.044276793,-0.03800402,0.016824912,0.08579126,0.02669742,0.045264024,0.058771953,-0.06689548,-0.03494348,0.12928437,0.111094706,-3.5480824e-08,0.17331712,0.034018256,0.05577623,0.020015221,-0.025393797,-0.028305894,-0.022979043,-0.00674564,0.11310781,-0.006127587,-0.118184365,0.04715448,0.026091067,-0.0037735363,-0.038656794,0.08144071,0.031937454,0.081356294,-0.0011809297,-0.006269019,-0.054279756,-0.049923692,-0.006402358,0.016825011,-0.010280654,-0.0028506664,0.08730972,0.03540262,0.08863302,-0.040570844,-0.011508641,-0.063105665,-0.05397011,-0.04558892,0.0013116116,-0.01965124,-0.07988903,-0.07194545,0.064414725,0.026022725,0.07695379,0.019470844,-0.011312168,-0.005006529,-0.0054746172,0.017753646,0.067153424,-0.034050304,-0.06738368,-0.02610651,-0.030420458,-0.0055769766,0.023197994,-0.05778571,-0.10939651,0.0008409314,0.025872085,0.036172915,-0.049163755,-0.014182391,-0.07380111,0.09632531,0.12875685,0.07475581 +3.4.24.67,Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin L. A 25.5 kDa peptidase in family M12 (astacin family),384,1.0,-0.03948574,-0.009154999,-0.057216477,-0.02702796,-0.11316739,0.0076445816,0.031531237,0.046053804,0.0114579145,-0.026109314,0.116880424,0.0052228384,-0.08516374,0.048238356,-0.055454656,0.011355568,0.021733003,-0.04833135,-0.07693788,0.0056006885,0.018388985,0.0008030332,0.01787815,-0.006304374,-0.012348296,0.031026654,-0.038430206,-0.033372752,0.03055564,-0.0781863,-0.040832777,0.029119898,0.062308483,-0.062214505,0.036701374,-0.029297834,-0.017060164,-0.031898353,0.08452276,0.042590875,0.085640155,-0.004972736,-0.066816755,0.0061167832,-0.025729854,-0.08766696,-0.020615531,-0.06319617,0.070945814,0.011733874,-0.11527525,0.013603245,-0.025994487,0.04769799,-0.027976777,0.08280501,-0.09148667,-0.06840508,-0.0009516776,0.0014161975,0.049285367,0.05346656,0.00056285976,-0.021742946,-0.047593262,-0.032253183,0.028315453,0.00233312,0.041976124,-0.0017299036,0.04761258,-0.015340287,0.020357879,0.058746427,-0.008098763,0.049402487,0.0042888834,-0.04281488,-0.04188132,-0.008696331,-0.016321648,-0.08933018,-0.048607815,0.084963545,-0.04452387,-0.0020071443,0.081683524,0.048556376,0.025092347,-0.08260669,0.015995849,0.0015376182,0.043574467,-0.046355378,0.014135596,-0.037904557,0.030201884,-0.08439749,-0.06281083,-0.008805853,-0.010701284,-0.04029905,-0.048304804,-0.08902143,0.009293176,0.008717946,-0.025127344,-0.015735272,0.07767509,-0.045885246,-0.07540444,-0.07253521,0.02853977,0.056649223,-0.038161546,0.016409576,-0.04511032,0.016122716,0.060695518,-0.015889917,0.055964574,-0.05684281,-0.06574226,0.003380858,-0.00456722,0.08395094,-0.039853204,2.4419205e-33,0.004378973,0.047947787,0.052884314,0.00285011,0.05535363,-0.05689934,-0.041493695,-0.043472134,0.021177199,-0.07388745,-0.07752747,-0.0031410751,-0.096615635,0.0019092669,-0.01044127,0.02216882,-0.006343974,-0.023375936,0.005665287,0.038999096,-0.004505225,0.087306105,-0.03440103,-0.06764934,0.0729213,-0.021622268,-0.050864197,-0.04895997,-0.0043686973,0.032764666,0.035731107,-0.106785364,-0.08568405,0.006410077,0.049073465,0.027376184,-0.0038805734,-0.078213684,-0.022189138,0.04312309,-0.0036807843,-0.06631715,0.01816468,0.048722193,0.046921078,-0.04303688,-0.060483534,0.124311045,0.039185744,0.0030490607,0.024596564,-0.05115723,0.014567818,-0.018854922,-0.044638082,0.014873624,-0.011229559,-0.010035967,-0.029064715,0.07135173,0.06161784,-0.030062344,-0.040210623,0.016784789,0.08988914,0.025049955,-0.08402492,0.007882754,-0.065087095,-0.047037583,-0.105246305,-0.04098939,-0.027944207,0.0017081191,-0.010788518,-0.050414737,0.048281267,0.054268125,0.014134666,0.0016059278,0.08020045,0.04080092,0.054342788,-0.023872515,-0.080211684,0.015380415,0.045079507,0.00059928256,0.026477883,0.08275864,2.065221e-05,-0.007210137,-0.00013568706,-0.034469083,0.007429808,-3.722203e-33,-0.023118423,-0.10707931,-0.004856414,0.009441784,-0.009916911,0.061124086,0.080441624,0.11772058,0.038272858,-0.009240963,-0.01782805,0.009664361,0.034356315,-0.07620788,0.028475352,0.06680078,0.11551833,0.053464632,0.01800529,-0.07480324,-0.09328806,0.07090901,0.047834143,0.15496989,-0.0064769327,0.025384007,0.050690513,0.0015210707,-0.05398207,0.041601725,0.0077962754,-0.024040367,-0.024084931,-0.022524336,-0.036689576,0.04397812,0.002460444,-0.027421601,0.026579399,0.007966669,-0.037010446,0.0024248613,0.05555971,-0.011519707,-0.020035824,0.043725368,0.00030738756,0.016947726,-0.04730588,-0.016349593,0.048100967,-0.028891502,0.011975369,-0.016517874,0.085818194,0.031077519,-0.018343166,-0.03829082,0.05013526,-0.045498442,0.034284424,-0.025758168,0.020453414,0.016885336,0.04212892,0.042972263,-0.04480449,0.016960457,0.0049367594,-0.028690357,0.0016133946,0.047438916,0.015157898,-0.0174923,-0.03054535,0.10811612,-0.12286349,-0.12854992,0.028022995,-0.024033206,-0.032892056,0.013339994,-0.026599208,-0.03327802,-0.052376784,-0.044250764,0.016659133,0.0915494,0.027420584,0.041911498,0.048928875,-0.07464826,-0.037380528,0.11698507,0.117681615,-3.6377156e-08,0.1673469,0.046344686,0.048632775,0.022881558,-0.023442447,-0.026030324,-0.019503519,-0.007871787,0.116278395,-0.006734629,-0.1268609,0.053266797,0.019930754,-0.0028464897,-0.042470023,0.082044594,0.03133093,0.08448171,0.0016916305,-0.0057634087,-0.052787356,-0.04943621,-0.007123193,0.012331115,-0.004669256,-0.0014202053,0.08698404,0.033895157,0.08568559,-0.03717738,-0.011773035,-0.06955933,-0.043521896,-0.047522016,-0.002614381,-0.013070969,-0.08716596,-0.068083525,0.06586622,0.026689127,0.074377745,0.02386347,-0.010848797,-0.0066226614,-0.013361908,0.019106101,0.072308965,-0.03557387,-0.06730364,-0.020292398,-0.022041263,-0.013775597,0.025703717,-0.062354073,-0.10506039,0.0016102766,0.027208937,0.036035217,-0.054308318,-0.015912438,-0.08885115,0.098453015,0.1205182,0.07264189 +3.4.24.68,"Zinc enzyme produced by Clostridium tetani. Proenzyme of 150 kDa is processed to disulfide-linked subunits of 100 and 50 kDa, the latter being responsible for the endopeptidase activity. Weakly inhibited by captopril, and phosphoramidon. The clostridial neurotoxins disable the neuroexocytosis apparatus, and have been described as the most toxic substances known. Tentoxilysin acts at the spinal inhibitory interneurons, blocking the release of various neurotransmitters to produce spastic paralysis. Type example of peptidase family M27 (tentoxilysin family)",384,1.0,-0.017679153,-0.03756729,-0.105981946,-0.01359841,0.069250025,0.0072193174,0.009748935,0.08906078,0.0013711421,0.03582004,0.07045482,-0.0042139105,0.07486092,0.113365896,-0.09600859,0.020669203,-0.009753519,-0.03240543,0.0014261693,0.044736676,0.045971774,0.06682747,0.032500535,-0.021506615,-0.04447659,0.02470843,-0.00059888203,-0.026210215,0.06207266,-0.042402525,-0.0070137866,-0.06824178,-0.030501442,-0.040691826,0.14606555,0.0269032,-0.04424281,0.0031009582,0.04670051,0.0042126058,0.03746755,0.052263565,-0.04749106,-0.073447295,-0.015325849,0.019977318,0.013109187,0.02558082,0.018651666,0.011619899,-0.015630055,-0.11419492,0.049299233,0.06222392,0.04454832,-0.046980433,-0.08787452,0.0046596644,-0.010102487,0.05558544,0.017879372,-0.0017646888,-0.002840891,-0.038390197,0.010793785,-0.030149885,0.006666293,-0.058164578,-0.012038558,-0.058291912,0.028309872,-0.04960952,0.0011336266,0.051513974,-0.0036882064,0.08663465,0.014512735,-0.08922583,-0.057512067,-0.0428983,0.019771948,0.017615106,0.07243193,0.06808767,0.11224463,0.012062242,0.049169056,0.07141771,0.02672084,0.035860233,0.05721278,-0.00116171,0.019599488,-0.011030126,-0.038649004,0.026922578,-0.022717418,0.03119773,-0.058795728,-0.03254048,0.018720653,0.010010831,-0.0494112,-0.04893399,-0.0026193704,0.037699018,0.091318116,0.043463018,0.044167846,-0.010160945,-0.06733828,0.032001067,0.025139647,-0.008540322,-0.008089147,-0.0045767385,0.051181313,0.043472193,-0.009279354,-0.023973916,0.04349804,-0.0040157763,0.019977393,-0.01737088,-0.025954597,0.09121264,-0.12011568,5.2906143e-33,0.031514533,0.036103852,-0.022516469,0.021037756,0.041418474,0.040618073,-0.048845552,0.012435638,0.054250676,-0.03157557,-0.13676834,-0.12333396,-0.004406844,-0.012047965,-0.035616435,-0.044919852,-0.03788284,-0.041008733,0.040570434,-0.0037013122,0.040021535,0.021286825,4.1870975e-05,-0.017356891,0.07459104,0.054233253,-0.040585976,-0.0062828194,0.049153924,0.0042666923,0.02688203,-0.063037,-0.1045544,-0.08117897,0.059174165,-0.01725992,0.020311013,-0.057569083,-0.051355015,-0.04131625,-0.036633477,-0.0060147233,-0.09243641,0.009069774,0.0112106,-0.056959398,-0.027179316,0.07194113,0.05182307,-0.08857684,0.038843557,-0.008264166,0.04060376,-0.09109873,-0.07948346,0.020084491,-0.010854788,-0.011480123,0.12839954,0.06549901,0.035359345,0.04627101,-0.063458465,0.01579121,0.056034856,-0.04630627,-0.07291293,-0.0512268,-0.035380572,0.01761453,-0.06375236,-0.024734348,0.014962968,0.02410493,0.021616017,-0.09216244,-0.020812763,-0.04490347,0.054203875,-0.025470218,0.09960648,-0.037805654,0.04510529,0.02229386,-0.046522897,-0.06455996,-0.05751006,0.007539582,-0.05807246,0.025007406,0.039703995,-0.051325914,-0.057843465,0.017066352,-0.11030176,-4.788685e-33,0.041269798,0.009116531,0.05654379,-0.10501049,-0.026815895,0.061314758,-0.03579502,0.006495341,0.019486533,-0.06789239,0.080832124,-0.031025216,0.05157587,-0.003256986,-0.015083617,0.02602915,-0.08178417,0.06344099,0.041678727,-0.07616346,-0.04314052,0.05473895,-0.015105234,0.027906006,0.058514122,0.08393667,-0.025152553,0.09161299,0.054683488,0.07235136,0.0023179739,0.068734124,0.011246219,-0.017480224,-0.07711378,0.08538,-0.09182932,-0.063265964,0.031551562,-0.06222524,0.022245454,0.023052527,0.034023784,0.047259003,0.05901683,0.0135016935,-0.09385796,-0.038149673,0.028022734,-0.051239006,-0.033074547,0.020037705,-0.0115549695,0.008740342,0.09827219,-0.054315828,-0.054033384,-0.029090038,0.0073351455,-0.07495565,0.00043133218,0.00065243914,-0.020681027,0.045736015,0.064235836,0.04254548,-0.057737567,0.047294617,0.072526306,-0.062484663,0.005943131,0.049747955,0.011831252,-0.06984094,-0.0666284,0.06745355,-0.046270195,-0.038084965,0.04954926,-0.039140318,0.024355043,0.017682476,-0.0050469977,0.0041457554,-0.0024848215,-0.023217104,0.040364973,0.08695973,-0.0057811975,0.010086492,-0.03310885,-0.04893966,0.040115558,0.08813817,0.0655468,-4.289192e-08,0.04921628,-0.06263859,0.086936235,-0.10683382,-0.05361278,-0.012231888,0.029049005,-0.017026737,0.0015939795,-0.06351225,0.028443981,0.014273313,0.033476513,0.061105695,-0.021580778,0.091505945,-0.07501045,0.06638379,0.026997741,0.047654442,-0.04659868,-0.0050061815,-0.033517122,0.052789636,0.020198576,-0.06866057,0.0024858806,0.054557346,-0.047588937,-0.047432724,0.010019755,0.0023434006,0.008850449,-0.024498986,-0.11349439,0.04277209,-0.075078,-0.013715166,-0.030224878,0.004753987,0.027858375,-0.01818299,-0.08275021,-0.013482777,-0.025564702,-0.05583939,0.0022349576,0.008286144,-0.02714972,-0.008246317,0.08297786,-0.014958916,-0.014586926,-0.023656096,-0.055437047,0.018493176,-0.025726644,-0.0352305,0.004948956,-0.12521015,-0.0320843,0.04276657,0.2033931,0.035576325 +3.4.24.69,"This zinc enzyme, produced by Clostridium botulinum, occurs as forms A-G that differ in specificity of action on the proteins of the neuroexocytosis apparatus [1-5]. The 150-kDa proenzymes of bontoxilysin are processed to disulfide-linked subunits of 100 and 50 kDa, the latter being responsible for the endopeptidase activities. Weakly inhibited by captopril, and phosphoramidon. Toxicity is due to action at the neuromuscular junctions that blocks release of acetylcholine, causing flaccid paralysis, in contrast to the spastic paralysis caused by tentoxilysin. In peptidase family M27 (tentoxilysin family)",384,1.0,-0.004548795,-0.06051876,-0.091135934,0.0024965608,0.036781747,0.005415757,0.023595817,0.08985029,0.0056786262,0.042066623,0.06371849,0.035647113,0.059833396,0.087372154,-0.07294,-0.012521413,-0.021717053,-0.0017871924,-0.052796017,0.038564064,0.07425324,0.04085912,0.028533496,-0.024864621,-0.043818273,0.010476913,-0.025566723,-0.051167216,0.055998217,-0.045724824,-0.020119442,-0.06721296,-0.025882894,-0.02707081,0.15783584,0.010442443,-0.008827006,-0.01204525,0.057530653,-0.025353985,0.03447805,0.07014237,-0.045405976,-0.01951484,-0.012962964,0.026588863,-0.0061782175,0.047453396,0.046686757,0.053090677,-0.021506362,-0.11136089,0.064451545,0.015405136,0.03434829,-0.015447217,-0.05879204,0.014034825,0.0036028156,0.0456057,-0.0070212106,0.013526937,0.033237506,-0.014438473,0.016928481,-0.055241015,0.0017146128,-0.07459147,0.009263991,-0.005377244,0.04280143,-0.06248628,0.007623623,0.05819518,0.049318705,0.08384593,-0.042494234,-0.08224979,-0.033089377,-0.02795529,0.042615794,0.025470555,0.06922867,0.06919879,0.08549886,0.005456296,0.05278382,0.034394007,0.022288214,0.01569815,0.017315371,-0.016889771,0.011778788,-0.00966352,-0.06092339,0.03562019,-0.013412081,0.022132449,-0.08281342,-0.038676925,0.03326115,-0.013815091,-0.007446307,-0.060017325,0.021143468,0.02600976,0.08252522,0.018622754,0.019276943,-0.039680615,-0.06514616,0.03768245,0.021552317,-0.0076327943,-0.002821861,0.014950268,0.05006144,0.03340413,-0.0003322892,-0.048816305,0.05043583,-0.01720839,0.010657904,-0.014477604,-0.023577556,0.05507969,-0.12945797,2.5821436e-33,0.020370465,0.009832111,-0.009690523,0.042277824,0.04187823,-0.0010547657,-0.032610156,-0.026683822,0.04034729,-0.027728707,-0.12619826,-0.15130879,0.016827125,0.00722572,-0.07498479,-0.017150477,-0.06261395,-0.05387618,0.037211586,0.0026180716,0.06338589,0.01103358,0.027465507,0.0033665004,0.09745581,0.051627208,-0.04594004,0.031057507,0.078703925,0.0031830275,0.053079776,-0.059516337,-0.10283616,-0.05923047,0.06670105,0.005650888,0.057348844,-0.040768057,-0.06418599,-0.0048822244,-0.05563351,0.005083145,-0.10074212,-0.0064256294,0.02722872,-0.058039643,-0.03445054,0.07517378,0.04470614,-0.0867016,0.013161027,-0.04111537,0.089640014,-0.03278046,-0.04188583,-0.0084338,-0.008580642,-0.034928285,0.081109196,0.055645633,0.0721447,0.035247695,-0.05844095,0.029196857,0.0338613,-0.039846472,-0.058762576,-0.032792404,-0.019359568,0.011951174,-0.054677315,-0.08158361,-0.023303233,0.05707534,0.03576079,-0.12577003,-0.018561972,-0.033968147,0.02284334,-0.0006354023,0.114004515,-0.036282953,0.017504556,0.022864496,-0.048923254,-0.060652915,-0.05491879,-0.03342569,-0.06257509,0.01126759,0.048798386,-0.041534703,-0.030535456,0.036911815,-0.11513513,-3.4443527e-33,0.021974301,0.022799795,0.08875023,-0.06219334,-0.05161328,0.052914105,-0.0038273737,0.0011984253,0.052384432,-0.0677052,0.060369246,-0.017523104,0.02509942,0.0016646063,-0.027890168,0.038460914,-0.08496436,0.060145568,0.032053538,-0.043448277,-0.07057401,0.03834362,-0.018940495,0.010804711,0.0751279,0.07050287,-0.0343489,0.0833951,0.036080513,0.06489702,0.034231696,0.081269756,-0.019608526,-0.03791256,-0.07977236,0.043271948,-0.05859523,-0.07851041,-0.027489888,-0.08111399,-0.0013828794,0.017071433,0.048342593,0.0279322,0.10711667,0.015187108,-0.08902191,-0.035389982,-0.01716498,-0.031094735,-0.019735368,0.007300888,0.016142214,0.046734538,0.101810224,-0.044474483,-0.03276286,0.036329634,0.0061365357,-0.031148952,-0.014268992,-0.030960906,-0.044418085,0.04696764,0.08094573,0.05965796,-0.04657055,0.08014586,0.057243213,-0.048998483,-0.022760356,0.046813317,-0.015128414,-0.05339093,-0.08039029,0.09158664,-0.08055658,-0.021145582,0.04101236,-0.022347778,-0.0053765625,0.016013216,-0.020654919,0.030266846,-0.005598031,-0.010530314,0.0019619383,0.108647205,-0.00567585,0.015959047,-0.052088723,-0.0946011,0.025711216,0.0514963,0.05960927,-4.3662496e-08,0.039912593,1.7720053e-05,0.029318111,-0.1411896,-0.052670185,-0.010584906,0.008571862,-0.014097248,0.011069473,-0.038181093,0.026623255,0.03547743,0.023951443,0.037736263,-0.04557527,0.09118172,-0.0603064,0.09684473,0.05183594,0.08373516,-0.05767386,-0.019275961,-0.06645441,0.054857437,0.044060666,-0.08910841,0.020599546,0.056195818,-0.05891394,-0.046986885,0.012363948,-0.007445776,0.011472929,-0.036701187,-0.121237256,0.017926523,-0.104416095,-0.0052364348,-0.005469302,0.018323358,0.019104257,0.040899184,-0.05263028,-0.02962909,-0.0074422117,-0.03777614,0.018985532,0.013695517,-0.05173747,-0.0244075,0.06181093,-0.010975162,-0.019362083,-0.039855964,-0.082573675,0.0027294878,-0.029374368,-0.006406527,-0.026495157,-0.11153531,-0.05119684,0.038157776,0.17691523,0.023088437 +3.4.24.70,"Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase, in peptidase family M3 (thimet oligopeptidase family), but differs from thimet oligopeptidase in lack of thiol-activation",384,1.0,-0.06681952,-0.020387823,-0.05412442,0.039873116,0.0986683,0.010409401,0.07217886,0.118011005,0.029433476,-0.01971285,-0.0033824355,-0.036366366,0.001037482,0.041489575,-0.022224404,-0.04732279,-0.01838116,-0.0074284384,-0.032330103,-0.068953164,0.062306195,0.058660366,0.055999182,-0.04967631,-0.067517154,0.035103664,-0.0059099137,-0.043081574,0.00895281,-0.014097196,-0.07929803,-0.09227643,0.06732392,-0.04296576,0.10547714,0.016316209,-0.009587188,0.0076849093,0.023302581,-0.0509653,0.090704195,0.065623455,-0.009680677,-0.015494485,-0.05331332,0.02651198,0.038637664,0.05436804,-0.02809564,0.052825265,-0.041526325,-0.103025906,0.04266206,0.017957222,0.024062218,0.045871504,-0.045165367,-0.05719905,0.025325254,-0.017819563,0.035088256,-0.01974346,0.014762284,-0.012552423,0.025481451,-0.0028685671,0.02298547,0.00583942,0.012835328,-0.06957241,0.01967801,0.036153052,-0.05293633,0.13409752,-0.019299055,0.08030901,0.096742876,-0.11118537,0.0051183305,-0.012142625,-0.018947892,0.023425093,0.06317579,0.047890432,0.061821304,-0.0023009588,-0.0106705,0.079197854,-0.012037332,7.296537e-05,0.033383228,-0.04813937,0.013250365,-0.054756727,-0.111767754,0.008185362,0.0060196887,-0.043754503,0.013509389,0.030997073,-0.0038253758,0.033979904,0.017143978,-0.05032434,0.0022388927,0.053532813,0.008981193,0.041731317,0.017901894,0.010588063,0.025383465,-0.027053328,0.071530074,-0.023974607,-0.005049364,-0.009141346,0.002503299,-0.043621276,-0.0113107655,-0.029565532,0.017613,-0.045034114,0.015856849,0.028661976,-0.01690012,0.07759264,-0.08744802,6.849603e-33,0.009140891,0.043182258,0.06948048,-0.022716746,0.08269093,0.017107919,0.027125474,0.025973115,0.049581118,0.008930926,-0.081615426,-0.13321167,0.015113115,-0.05267415,-0.047488164,-0.023433972,-0.09222759,0.03663438,0.026276972,0.05439575,-0.0014991087,0.08707455,0.008287649,-0.016558884,0.0301731,0.013922681,-0.028522125,-0.008984189,0.07541177,-0.004320036,0.036846656,-0.028167935,-0.08212335,-0.045525298,0.1096115,-0.044686474,0.061371446,-0.085588194,-0.01671002,-0.03076436,-0.0818844,0.0025480385,-0.048452243,0.0068905866,0.08637546,-0.12564144,-0.08530517,0.026242834,0.012402204,-0.0124304695,0.0022647472,0.0036336505,0.05797712,-0.097363256,-0.05454937,0.008485809,0.039549425,0.05796029,0.10018071,0.05604352,0.038648184,0.04825886,-0.08048571,0.037420794,0.033928923,0.015866468,-0.05137171,-0.048345108,-0.05162286,0.091151565,0.023815408,-0.008254776,0.01588219,-0.0044576623,0.0068404363,-0.05261976,-0.07583564,-0.029916445,0.05949557,-0.05890065,0.006554337,-0.00042004438,0.047473777,-0.004754672,-0.09497901,-0.0065198317,0.015792886,0.008568952,-0.035348933,0.020881778,0.015980251,0.025919627,-0.05101015,-0.017700171,-0.104943894,-5.39258e-33,0.01339064,0.0244029,0.023764612,-0.06474755,-0.057280563,-0.029386546,-0.0746523,0.05944808,0.06342376,-0.07428607,0.15507902,-0.02549133,0.03390896,-0.049365714,0.026758688,0.014845607,-0.028682789,0.06289415,-0.004302843,-0.040613223,-0.035510805,-0.041416768,-0.016497448,0.02805759,0.027467472,0.035456523,-0.07055656,0.10536603,0.03580699,0.073525175,-0.022596044,0.08814871,0.040313598,-0.092734896,-0.06853342,0.021926377,-0.008148809,-0.04165384,0.023077048,-0.0063733845,-0.008470555,-0.0011683188,0.060864557,0.09693883,-0.016074065,0.11346303,-0.075699136,0.007937054,0.045120582,-0.014427506,0.014361822,-0.06185978,-0.023697801,-0.020295748,0.045335293,0.011539748,-0.021090955,0.00017455839,-0.054418564,-0.046732374,0.041006297,-0.01733713,0.040279493,0.063985385,0.08065715,0.039586294,-0.05590826,0.08047672,0.045425825,0.009013413,-0.0003866728,0.071571276,-0.0053329635,-0.0660947,-0.010956227,-0.015610132,-0.034631774,-0.0013768566,0.013367586,0.01603795,0.033241138,0.037938744,-0.023285689,-0.037308898,0.013879657,-0.034986943,-0.021193,0.13547312,-0.025972048,0.06433,-0.11407501,-0.050966103,-0.0050156307,0.0917722,0.00070567074,-3.4235832e-08,0.0320382,-0.06559034,-0.022402268,-0.10297396,-0.07372019,-0.040117595,-0.022367405,-0.06245966,0.028041149,-0.038245946,0.028582823,0.07800309,-0.008412813,0.0012856012,0.018638747,0.057639576,-0.056384582,-0.027733995,0.0049514705,0.017913818,-0.023013175,0.03673109,-0.01669573,0.018367933,0.025147952,-0.035967246,0.0009695639,0.025796168,-0.00604434,0.010516653,-0.03252044,-0.004449497,-0.01454271,0.008146891,0.016783565,0.044858817,-0.12105239,-0.010754855,-0.045148414,-0.059368923,-0.024444219,0.021661984,-0.093584746,0.00046081914,0.0022260135,-0.04704595,-0.021621307,0.078710765,-0.03200492,-0.11979631,-0.065454185,-0.034752943,-0.02484105,-0.036797173,-0.0849811,0.035850573,0.009515002,-0.060511854,-0.043667946,-0.06635516,0.032743644,-0.0057853153,0.2167581,0.05040384 +3.4.24.71,"A phosphoramidon-sensitive metalloendopeptidase in peptidase family M13 (neprilysin family). An integral membrane protein predominantly of endothelial cells, which generates the potent vasoconstrictor endothelin 1 from its inactive precursor",384,0.99999994,-0.030749256,-0.057998568,-0.09263468,0.028847659,0.074620925,0.041017815,0.0056738593,0.082055554,0.0057264827,0.0047037494,0.046226446,-0.07159264,-0.09447719,0.06348125,-0.039204743,-0.047976635,-0.037372496,-0.032761045,-0.04185644,-0.021125833,0.10277563,0.05326025,-0.014301542,-0.060484406,-0.0036457265,0.009178216,-0.0063093025,-0.06260663,0.052607387,-0.018907156,0.012963679,-0.10790579,0.003263797,-0.02737622,0.058663025,0.032765865,-0.035354417,-0.033140898,-0.033612203,-0.0070870393,0.09390087,0.008141768,-0.054646675,0.007477896,-0.021715343,-0.008861996,-0.0133689,0.04707781,0.05498772,0.041762155,-0.011363966,-0.078178495,0.012266516,-0.014401273,-0.044708468,0.05215197,-0.07613336,0.017903425,0.072071336,-0.02035964,0.06824831,0.012119769,-0.005616505,0.00072843477,-0.018394276,-0.02241798,0.023597674,-0.018516744,0.00074390776,-0.0356356,0.016665079,-0.021539357,-0.020446409,0.014476745,0.03660421,0.15082097,-0.002437498,-0.016186919,-0.022660268,-0.052399997,0.06618079,0.02770782,0.035949856,0.04467187,0.053728655,0.07815425,0.028380373,0.010292592,-0.0069264416,-0.035329502,-0.007221186,-0.06716853,0.0074563366,0.037383366,-0.09462351,0.046895426,-0.0158661,0.032232285,-0.061375145,0.014781726,0.02010534,0.08816674,-0.013673032,0.028693017,0.00066219806,0.073151834,-0.018667027,0.047979772,0.053171575,0.031657543,-0.015688036,-0.02986282,0.04457551,-0.031892702,0.0702235,-0.010023652,-0.05059097,0.016363025,0.008360263,0.007298987,0.049412344,-0.0020372875,-0.085434824,-0.022765623,-0.01038084,0.055472728,-0.06776238,4.9827685e-33,0.032877114,0.014019313,0.05648573,-0.005279614,0.06844318,-0.04450045,-0.05231472,0.020654596,-0.025436247,-0.01914086,-0.104287885,-0.09794911,-0.042302165,0.01928331,-0.040577393,-0.010846719,-0.069386795,-0.022198679,0.08807797,0.016633373,-0.018237745,0.058587052,0.001825669,-0.06098667,0.047602322,0.007039065,-0.011492564,0.03032475,0.07254959,-0.016628902,-0.055395413,-0.060295403,-0.04707045,-0.03752443,0.013285634,-0.07520325,0.076830134,-0.119083464,0.014060424,-0.047436524,-0.046492103,0.05350738,-0.055848166,0.0013113503,0.07012559,-0.108541176,-0.06353583,0.058560368,0.027456101,-0.03326669,-0.0019025767,-0.050041042,0.09586687,0.039982088,-0.04441595,-0.015901461,-0.053368557,0.040634867,0.054182373,0.00811571,0.051830787,0.049581,0.003868337,-0.044852987,0.03747495,0.022208638,-0.074501626,-0.033909842,-0.020998973,0.021495031,-0.078260995,0.020121101,-0.036715914,0.009451855,0.025791656,-0.064967416,0.009443063,0.04178224,0.0044708773,-0.02061129,0.08825622,0.05361532,0.011426237,0.05588968,-0.024445837,-0.07660582,0.008535894,-0.07440479,-0.04053143,-0.049872685,0.04665912,0.0018827867,-0.04002585,0.072079875,-0.09566862,-3.9635443e-33,0.10345073,-0.01668251,0.0376918,-0.076194376,-0.018873652,0.07201262,-0.006359817,0.009727157,0.006380261,-0.04747814,0.08053267,0.030643025,0.088159926,-0.090944305,0.0019886128,0.007813595,-0.0069198753,0.013082254,0.023380535,-0.021655818,-0.029296422,0.025226826,-0.007906075,0.035132926,0.07795884,0.01045069,-0.084169,0.04667216,-0.08002737,0.03704392,0.043313418,0.036895566,-0.06367522,-0.11175285,-0.076456904,0.014061449,-0.044497576,-0.0252896,0.07075426,0.052368604,-0.0042126467,0.015283902,0.082547314,0.03959901,0.05561139,0.073153354,-0.03880478,-0.028326984,-0.05727205,-0.05248139,-0.024748735,-0.0122309225,-0.061012696,0.12578467,0.07488901,0.0033270852,0.047895562,0.07977952,0.015165551,-0.01226227,-0.007667989,0.03910357,-0.006753334,0.011581284,0.09766527,0.05463284,-0.057700884,0.069029726,0.062312257,0.03080517,0.062236816,0.05777315,-0.002839061,0.015648764,0.01207068,0.0031977065,-0.054006834,-0.06423492,-0.0056641693,0.013350373,-0.018554514,0.05702008,-0.011096056,-0.036991727,0.031006724,-0.053729523,0.053328272,0.06320535,-0.006131639,0.06518834,-0.033534877,-0.06461647,0.0055217235,0.09174661,0.027296815,-3.410043e-08,0.017890483,0.022458605,-0.017373608,-0.14220054,-0.10365828,-0.08687644,0.00882348,-0.009999422,-0.002856395,-0.01805089,0.05690946,-0.028754747,0.020879658,-0.011936013,0.054065622,0.12635463,0.021360056,0.043147523,0.018161237,-0.01782213,0.021483649,0.00031246865,-0.10696993,0.005065656,0.07965094,-0.10100212,0.05791254,0.031272102,-0.035992905,0.05878359,-0.012406727,-0.018472908,-0.003127862,-0.008991464,0.005827908,0.07892934,-0.07674477,0.042630423,-0.03868461,-0.0821889,-0.01146076,-0.004175964,-0.04004888,-0.01212939,0.0008379576,0.0016269555,0.10152202,0.07144189,-0.0109286895,-0.03163674,0.0034855322,-0.020715784,-0.021585567,-0.0708191,-0.15843418,-0.06437971,-0.07318119,0.017050369,-0.021771824,-0.10060064,-0.015805114,0.035602342,0.16825587,0.05791894 +3.4.24.72,"A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake (Agkistrodon contortix contortix). In peptidase family M12 (astacin family)",384,1.0,-0.082981266,0.0017432439,-0.11301957,0.02934397,-0.012076788,-0.051894065,-0.03403263,0.040004924,0.02171372,-0.029583862,0.022322068,-0.107153356,0.038919058,0.08413645,-0.09211617,-0.016960144,-0.022503175,-0.030709095,0.021094909,-0.08291174,0.0065422636,0.10950903,0.069627434,0.04071335,-0.0563659,-0.0021638884,0.00868548,-0.0263515,0.012346596,-0.11603085,-0.009798085,-0.09787649,0.0073570125,-0.048966333,0.09952212,-0.012151331,-0.08018495,0.039660703,0.060764402,0.0056532645,0.064017534,0.11709911,-0.0022181252,0.02582936,-0.0052598263,-0.029719375,0.0068671624,0.00621328,0.048167743,0.009509371,0.025637254,-0.0321477,-0.09292126,0.021033006,0.05431011,-0.030798702,-0.12998115,-0.11876843,0.011725464,0.0059499885,0.089061886,-0.0066429595,-0.017706595,0.035123773,-0.12041189,-0.06768843,0.016344069,-0.001162009,0.0053958497,-0.02818784,0.028165365,-0.050870426,0.00029648538,0.04620537,-0.007804699,0.060803805,0.07981346,0.001297209,-0.028459202,-0.0005903256,-0.02623325,0.014495159,0.11067199,0.03223265,0.08019905,0.051723648,0.059274323,0.06762176,-0.018749274,-0.0012314263,0.07057803,0.032013446,0.029976496,-0.023576563,-0.006023845,0.009291177,0.009963856,0.052975453,-0.06891547,0.06669559,0.024008896,-0.01970176,-0.040279284,0.0059675556,0.010107548,-0.012415257,-0.05567407,0.016720574,0.053792506,0.0050304234,-0.014759788,-0.015542536,0.021417955,-0.04893064,0.08441254,0.03713806,-0.025446411,-0.012207173,0.04823789,-0.04206289,0.033866554,-0.044470564,-0.03814757,-0.01402516,0.026892675,0.016387504,-0.15208888,4.052967e-33,-0.019388739,0.023460612,0.019826373,-0.0072035533,0.0017482465,-0.03970017,-0.09042457,0.00081636413,-0.07241112,0.014992786,-0.065102346,-0.045800664,0.008787225,0.024860492,-0.09180798,-0.017526334,-0.031266708,0.05014342,-0.0217614,-0.08784435,0.041935906,0.07641597,-0.056029625,-0.0065006334,-0.008185218,0.0042985813,-0.07132939,-0.0052494733,0.10134773,0.00608042,-0.062816896,-0.097750455,-0.007973686,0.02366471,-0.07660151,-0.0481446,0.013689336,-0.084764145,-0.029461723,0.072068565,0.019336576,0.050726738,-0.05614367,-0.025295557,0.006348282,-0.028933177,-0.054802738,0.07377279,0.039486196,0.04862255,-0.017630897,-0.023899315,0.16111849,0.0122902375,-0.06728509,0.06648538,-0.018134678,-0.0280556,0.11246184,-0.015469641,0.065297306,-0.01180453,-0.056713086,0.022257784,0.046861567,-0.0026180928,-0.0325902,0.009723085,0.066525586,0.017919177,-0.07756383,0.049114883,-0.020780552,-0.045573577,0.047500435,-0.041175958,-0.04326069,-0.0029160033,-0.095191635,0.05174216,-0.038698923,0.0032202378,0.07895281,0.0031675666,0.060557924,-0.010147785,0.052064206,-0.06961007,0.037867032,0.094072536,0.011053659,-0.042920016,-0.09333193,0.0023997175,0.010378622,-2.8137509e-33,0.069855295,0.00036792972,0.060971923,-0.037345964,-0.05798977,0.036755145,0.032762453,0.050067462,0.028959619,-0.083765246,0.03360127,0.031625483,0.023261959,-0.0035055755,0.058834713,0.004644813,0.023853377,0.064767055,0.020031746,-0.023456987,-0.12913471,0.025448129,-0.05167634,-0.08507861,0.0633473,0.068776,-0.013172296,0.02945802,0.008903346,0.0031931405,-0.043000523,0.093815856,0.0056076986,0.026170224,-0.11354277,0.029058542,-0.026836477,-0.042744447,-0.0084098615,-0.0069769747,0.054165773,0.09373041,-0.00030971074,0.08133488,0.0009353761,0.029209923,-0.028584823,0.06809767,0.0021947091,-0.04562467,-0.006715024,0.01672185,0.036639962,0.032429785,0.05374814,-0.03603265,0.042239767,0.035815462,-0.0136142215,0.02058513,-0.03339524,-0.07545809,-0.05569356,0.04507126,0.07579277,0.09235483,-0.05119932,0.021896072,0.01514371,0.018776594,-0.016546598,0.040839292,-0.039328773,-0.054428525,0.035877388,0.052629575,-0.022218801,-0.0041366387,0.028355272,-0.006086033,-0.028281957,0.015493211,0.0073650694,-0.0148105305,-0.032238167,-0.056345038,-0.017575713,0.102964915,0.049207803,0.010578815,-0.029099168,-0.026651906,0.029521305,0.05394759,0.057752036,-3.5648142e-08,-0.0019499384,-0.018496895,-0.0030829378,-0.04163218,-0.030184485,0.075045355,0.0025638866,-0.06450373,0.022388896,0.055354144,0.04194129,0.0015896071,0.022288878,-0.043487776,-0.045265537,0.10189978,-0.039175928,0.010781025,0.04307145,-0.060392644,-0.04278071,0.0710723,-0.02104411,0.039944354,-0.028300077,-0.046515256,0.010859537,0.047161043,-0.026050912,-0.012677936,-0.02667304,-0.03090115,-0.022802422,-0.060871072,-0.029052477,-0.022202889,-0.040793665,-0.0013708355,0.07813306,0.0064034653,0.11506349,-0.05879199,-0.053905245,-0.03631706,-0.096579425,0.008144377,-0.0031542787,0.012633094,-0.012234706,-0.056528028,0.030672766,0.07279764,-0.021475667,-0.08011108,-0.07020791,-0.024197435,0.0043039336,-0.018039355,-0.10872319,-0.060691677,0.02121175,-0.0021463984,0.18656299,-0.0061120247 +3.4.24.73,Hemorrhagic endopeptidase from the venom of the jararaca snake (Bothrops jararaca). The 52-kDa enzyme contains a disintegrin domain [3]. In peptidase family M12 (astacin family),384,1.0,-0.015155088,-0.008151615,-0.11060334,0.00224998,0.0037035893,0.008798542,-0.0492277,0.057550404,0.040837504,0.0594256,0.040784527,-0.08078479,-0.046381887,0.12042959,-0.050041642,-0.020395637,-0.047668714,0.008182287,-0.005735388,-0.044925578,0.08228845,0.11613242,0.043653786,-0.00015923039,-0.042542502,0.041144066,0.018847078,-0.078680605,-0.015181953,-0.109536454,0.037586093,-0.12272943,-0.0077384855,-0.09697649,0.12062385,-0.0425222,-0.0624354,-0.0025492257,0.075337976,-0.026915371,0.03792281,0.05914593,-0.038575307,0.032858517,0.0037630768,0.0073331073,0.007899919,0.050219882,0.07942071,0.0418441,0.030859113,-0.010463941,-0.102842815,-0.0010777991,0.020525923,-0.018950177,-0.046708193,0.004862018,0.01683931,0.042055327,0.07202925,0.03064489,0.0031191013,0.012441455,-0.025603212,-0.14840284,0.030774957,-0.007428881,-0.0073908325,-0.049302448,-0.019752955,-0.088431515,-0.0049767382,0.08425136,0.043167412,0.07555607,-0.021238176,0.007925191,-0.057461392,-0.035310023,0.014470495,-0.014031806,0.12889233,0.084925905,0.060941707,0.056451995,0.020411294,0.079804406,0.045800425,0.028382048,0.064673565,-0.056660093,0.023072425,-0.02815902,0.014335744,0.0107214395,-0.0016175036,0.050693013,-0.06784664,0.012791964,-0.027156234,-0.070402816,-0.03856225,-0.03385723,0.009816405,0.03068251,-0.07398053,-0.0056104027,0.11240316,-0.055013057,0.004168281,0.008447053,0.02042917,-0.04771058,0.099886835,0.013569435,0.008407664,-0.015316603,0.043844994,-0.023056865,0.030844614,-0.07409727,0.006439663,0.035470705,0.00084759627,0.03750744,-0.15280825,3.0211452e-33,0.016086139,-0.017314024,0.065644935,-0.007906024,-0.059685662,-0.030238597,-0.060797475,0.024209183,-0.059432145,0.010715908,-0.06440876,-0.059471898,0.031071426,0.0056399894,-0.045818966,-0.005757707,-0.034473833,0.042913914,0.004204459,-0.019455351,0.040832814,0.08669344,-0.050479963,-0.0017658178,0.04597652,0.0837124,-0.060802206,-0.0070647406,0.13373587,0.032756645,-0.035810307,-0.112636186,-0.044094644,0.037474472,-0.038817387,-0.024149835,0.047465537,-0.08829052,-0.05502385,-0.018633643,-0.018561777,-0.007289133,-0.09199951,0.0070221187,0.020591805,-0.08286994,-0.02716069,0.054529823,-0.0008653929,0.04826559,-0.0438367,-0.026725598,0.14525586,0.008450971,-0.05847028,0.08808661,0.020537648,-0.006206812,0.09271847,0.007891598,0.031228308,0.035898454,-0.08695349,-0.02097169,0.037194856,-0.004207665,-0.021236,-0.015878292,0.03460019,0.034968372,-0.09384699,0.027446182,0.027195664,-0.023008185,0.014241702,-0.045139205,-0.07526721,0.063733675,-0.030733218,0.00587745,0.02693936,0.0006436052,0.05575819,-0.036851533,0.0321134,0.06934215,0.04403954,-0.12487382,-0.04916424,0.09958976,0.035133485,-0.011827397,-0.046886526,0.023562016,-0.0035694053,-1.9661691e-33,0.048649807,-0.02421489,-0.007398713,-0.034585625,-0.04797843,0.028210789,0.007983544,0.030807069,-0.0038841858,-0.060494147,0.07144911,-0.0553926,-0.0027832515,-0.011898958,0.014603908,-0.012528008,0.07194772,0.03557559,0.04770418,-0.03672967,-0.0607595,0.016204244,-0.01154972,-0.066729814,0.077507794,0.019385662,-0.02637388,0.026376713,-0.020360747,0.026016345,-0.0020162223,0.057205144,0.007961863,-0.043810073,-0.0881693,-0.004672071,-0.12768307,-0.046990518,0.03597331,0.0024884066,0.0063002515,0.02300511,0.013523067,0.08774155,0.02771446,0.007562202,-0.07516081,0.13281964,0.080113806,-0.103124775,-0.020637007,-0.009392872,-0.0011562589,0.02884597,0.035007738,-0.053668544,0.051907707,0.05403335,-0.014301131,0.0031815614,0.0102181705,-0.04241379,0.002750876,0.041890483,0.12976605,0.08269225,-0.06664162,0.039181307,-0.00919808,0.015314291,0.034717873,-0.01661913,-0.005110677,-0.00086030434,0.0040073553,0.0063563436,-0.033137932,-0.012951203,0.042872988,0.0032391066,-0.026159778,0.011919455,0.010351679,-0.01668766,0.044018667,-0.067685716,-0.035481088,0.08083155,0.005437358,0.03789999,-0.041115507,-0.0040118224,0.047647312,0.06995833,0.050677195,-3.2737553e-08,0.0012689617,-0.050626174,0.020417096,-0.092337586,-0.030596813,0.010000213,0.009360932,-0.0028291326,0.03220782,0.008029936,0.05456837,-0.0011773705,0.0037841152,0.029498646,0.007090592,0.07630011,0.018254768,0.055066925,0.04175618,-0.049288988,-0.040556017,0.02609118,-0.026731836,-0.03494469,0.0016147868,-0.046274524,0.012288324,-0.020143153,0.028017407,-0.02677036,-0.023862608,-0.059716348,-0.0132943755,-0.067237616,-0.04208723,0.048433956,-0.043777328,0.004101298,0.0429038,0.01825279,0.055035494,-0.037573036,-0.035437692,-0.0032586404,-0.012916043,0.030789318,0.075691685,0.018122979,-0.07014269,-0.105577365,0.021258213,0.021331197,-0.03328125,-0.09210208,-0.11680802,-0.040370136,-0.022379834,-0.02096467,-0.051816355,-0.053824756,0.010445713,0.023882043,0.16995889,0.045332145 +3.4.24.74,"Thought to be a cause of diarrhoea in animals and humans. Hydrolyses extracellular matrix proteins, and disrupts tight junctions of intestinal epithelial cells. Also degrades intracellular, cytoskeletal proteins actin, myosin and others. In peptidase family M10 (interstitial collagenase family)",384,1.0,-0.030617237,-0.08232052,0.014174837,-0.020944588,-0.002762115,-0.056641,-0.007533368,0.100709,0.060942344,0.00884793,-0.02112285,0.049356956,0.017955707,0.11376404,-0.1035954,-0.038886458,-0.059388537,0.005299882,-0.044425726,-0.020094898,0.016180495,0.03050038,-0.012805709,0.039596383,-0.09369381,-0.040531695,0.102514915,0.014917855,-0.003310795,-0.087953955,-0.033303283,-0.037256703,0.086105436,-0.04444447,0.062642984,0.028580682,0.060015175,-0.017806511,0.03478687,-0.017292991,0.093074396,0.014973831,0.06194752,-0.06091288,0.072528355,-0.044844247,-0.022494478,-0.017259756,0.0735029,0.05299128,-0.09259688,-0.029894456,0.04757589,0.04363069,-0.02742463,-0.09687192,-0.055730328,0.0073782746,0.013709667,0.005909655,0.025108008,0.0027412667,0.031457894,-0.001204299,0.043186225,-0.0636724,-0.00063076254,0.058534037,-0.07625739,0.07697714,-0.020642681,-0.03358756,-0.0524153,0.06600858,-0.014503309,0.002437817,-0.08075286,-0.0058176583,-0.009513831,0.056503274,0.055155784,0.04256536,0.06025939,0.04951443,0.018861674,0.025376517,0.01422349,-0.016323522,-0.021261131,-0.092282675,0.030765433,-0.089091815,0.04760207,0.042919643,-0.009341908,-0.033484656,0.042449165,-0.081711866,0.01639826,0.021067256,-0.072528675,0.033014175,0.02263206,0.0055155205,0.032828584,0.09556168,0.0022731535,0.051844843,0.042464547,0.015707018,0.01104515,0.06407126,0.01472108,0.014558797,-0.0043922057,0.04717438,0.033552334,-0.034387756,0.0110888425,-0.012909254,-0.061426334,-0.047534145,-0.01717161,0.06454876,-0.052991353,0.0122711295,-0.039617132,3.936599e-33,-0.034019515,-0.1060519,0.032735463,0.028214827,0.042322487,-0.03678622,-0.021479724,-0.052040204,0.095530756,-0.1021832,-0.023431044,-0.019392226,0.02214392,-0.009944742,-0.09036208,0.06062731,-0.059699256,-0.07011497,-0.0102356905,0.0435191,0.023460673,-0.0065858993,-0.01500342,-0.06400322,0.020016847,0.05085604,-0.024636881,-0.021949027,0.09672767,-0.015271536,0.03177525,-0.05172763,-0.0032285245,0.06312925,-0.031882193,0.0207928,-0.0009438505,-0.07395084,-0.022097895,0.02998382,-0.06476791,-0.06554218,-0.029958133,-0.07792046,0.036944237,-0.09263294,-0.0036541729,0.072120085,-0.05927272,0.013046438,0.070725024,0.015238579,-0.020562217,-0.066050805,-0.099621326,-0.090940334,0.025987245,-0.070810884,0.02804871,0.073121585,-0.00812349,-0.035482217,0.01898752,0.0410931,-0.055495303,-0.036014196,-0.04551926,0.03573963,0.00410462,0.08023025,-0.07658179,-0.029267825,0.01679709,-0.031950634,-0.027062042,-0.13653196,-0.049199842,0.01598363,0.012819524,0.0465283,0.016216647,-0.09436527,0.03755123,0.057069734,-0.007837338,0.06404385,0.03408046,-0.035102673,-0.0024643927,0.086445615,0.12721281,0.01674374,-0.021331973,0.093619265,0.017461406,-6.75769e-33,0.06483952,-0.040858723,0.019248039,-0.048614074,-0.012895303,-0.015156323,0.06554945,0.08735358,0.054006897,-0.035112306,0.0075075324,0.0033912738,-0.014958172,-0.04698234,0.086283796,0.067887984,0.015135212,-0.005442049,-0.014044119,-0.096173935,-0.06023212,0.029675076,0.056316715,-0.03729369,0.020520898,0.032154907,-0.05902428,0.016678449,-0.059073277,0.06740419,-0.03210592,0.08754703,-0.074884005,-0.0055621727,0.016108152,-0.0036271873,-0.09706016,-0.07093441,-0.039321076,-0.10441062,-0.025582017,0.03251542,0.015955415,0.10656501,-0.006245643,0.06733637,-0.04227606,0.0008816917,-0.014160822,0.0133164935,0.010349627,0.002699059,0.056499843,0.028672824,0.014125492,0.038787864,0.003351346,-0.0050971815,0.015124179,0.09072898,-0.04966201,0.027873006,-0.07600662,-0.024536919,0.0783359,-0.0062678796,-0.15839964,0.00944404,0.04096823,0.059710257,0.070992224,-0.03138616,0.004264506,0.003221297,-0.041181624,0.06675337,-0.102173164,-0.000502235,-0.0035922714,-0.02214763,-0.08269116,0.05620179,0.0025866013,-0.01572965,-0.045806948,-0.055424344,-0.05133889,0.1327379,-0.012690743,0.031077765,0.093920454,-0.04496035,-0.04027812,0.004333811,0.041653704,-3.4913217e-08,-0.020778755,-0.08282385,-0.052027177,-0.014438486,-0.018501718,-0.042541232,-0.02552676,0.10365382,0.06722858,0.047429558,0.026313389,0.03726993,-0.0048256554,0.008498592,-0.03685431,0.056013122,-0.028752783,-0.02397961,-0.006489021,0.0017579271,-0.06465027,-0.046625238,-0.061314516,0.10121902,-0.052076314,-0.022416865,0.006851375,0.10834561,-0.0495375,-0.07700765,0.0066961283,-0.015621494,-0.00021178513,0.061616205,-0.050442234,0.07272096,0.06356137,-0.028640466,-0.046004836,-0.088015206,0.01358926,-0.032143082,0.02567284,-0.08010726,-0.024487399,0.024703868,-0.06771136,0.07252337,0.057026558,0.0036895864,-0.045650322,-0.0133291725,0.004430366,-0.008459161,-0.044379268,-0.011969707,-0.01056857,-0.03357589,0.02713971,-0.0138493385,0.00018049186,0.007923338,0.10377369,-0.0057421965 +3.4.24.75,"A zinc-dependent, 25-kDa endopeptidase from Staphylococcus simulans. Lyses cells of S. aureus, in particular, by its action on the cross-bridges of the cell wall. Type example of peptidase family M23.",384,1.0,-0.012588298,-0.051876068,-0.1313576,-0.04566816,0.05913214,0.07544316,-0.025923597,0.07512803,0.034437913,0.067939095,0.07175801,-0.059326034,-0.025278274,0.08739515,-0.044346716,0.01966811,-0.09382509,-0.029502647,-0.0287931,-0.0014253975,0.06652897,0.08678675,-0.006903176,-0.051463395,-0.0377409,0.006878001,-0.03230357,-0.09502989,0.015339397,-0.019092869,0.03914259,-0.07867418,0.04158173,-0.028480938,0.088448614,-0.026505517,-0.03460014,0.025821045,0.07438812,0.002402,0.033614818,0.092605695,-0.0079870485,-0.00524885,0.020684931,0.06233454,0.07892301,0.06318652,0.013190621,-0.015789092,0.021178694,-0.068659246,-0.05292456,0.006356709,0.0029938968,0.030683527,-0.09128358,-0.024752142,0.043812588,0.043000177,0.10856548,-0.021400217,0.035106458,-0.051205017,0.0027271027,-0.08557333,-0.010874803,0.030143816,0.025179973,-0.007437082,-0.028145352,-0.026181357,-0.030933894,0.038529098,-0.0035806166,0.13533852,-0.033464976,-0.083998136,-0.05066773,-0.033305723,-0.04476742,0.019266112,0.07027485,0.10629404,0.06771322,-0.0034434807,-0.002620294,0.072112024,0.0046323226,0.034968097,0.05887396,-0.0613113,0.028471416,0.0051458357,-0.06359478,-0.026411079,0.012939438,-0.021373058,-0.0052585527,-0.013822306,-0.008725666,0.024425922,0.06506005,-0.048389714,0.026912814,0.053653765,-0.018675705,-0.014855764,0.048575655,-0.03284839,-0.0018584161,0.008039899,-0.055278275,-0.11094459,0.02728481,-0.030925075,0.04487676,-0.05447778,-0.0293339,-0.040017027,0.036207765,-0.027057666,-0.01398821,0.008011208,-0.023471072,0.078790694,-0.029309932,-3.5525446e-34,-0.045140706,-0.0024172617,0.03591924,-0.021725858,0.062459875,-0.010358385,0.01308835,-0.023976173,0.02768323,0.0014663474,-0.13564087,-0.03919382,0.0025152962,0.023970185,-0.05226253,0.03631365,-0.047532395,-0.02656849,0.012552635,-0.0018948304,0.08047058,0.06427304,-0.044743635,-0.08652291,0.043907713,0.009672168,0.04762493,-0.017638275,0.07691777,-0.018614875,0.008280115,-0.04693924,-0.07523469,-0.034367166,0.048941053,0.020958548,0.00857661,-0.08710149,-0.0140760355,-0.05601424,-0.022715671,0.018087033,-0.027315045,0.07872562,0.04140222,-0.08320669,-0.035077553,0.02132455,0.027290823,-0.010178759,-0.008355426,-0.028426483,0.017072596,-0.029559236,-0.05115421,0.045924075,0.024726529,0.07536458,0.08252114,0.08275519,-0.026679013,0.01664781,-0.09361528,0.041379545,0.026276708,0.05040448,-0.049311448,-0.033135734,-0.016720127,0.039233908,-0.06760739,-0.012753038,0.04354506,-0.0013220443,0.015696533,-0.0393774,-0.061679244,0.045009255,0.06764844,-0.04945027,0.011882654,0.021362137,-0.003236542,-0.001338988,-0.09112674,-0.06063194,-0.01986715,-0.062136047,-0.09458409,0.04983492,-0.0023972737,-0.071377516,0.010370648,0.102517076,-0.10791048,-6.2999513e-34,0.013499196,-0.052888993,0.019254478,-0.07295425,-0.010067548,0.10337386,0.043115202,0.04318587,-0.040649522,-0.020658497,0.064723745,-0.019591097,0.052474406,0.036232363,0.02334642,0.026018748,0.06140294,0.07458209,0.026851486,-0.05880924,-0.09416343,0.051696163,0.05290052,0.004647283,0.086259715,0.05428985,0.0016454335,0.045701407,0.018806757,0.006479443,0.012138709,-0.005273234,0.005966259,-0.06973765,-0.091512784,0.0494427,-0.007835373,-0.029692687,0.053418715,-0.043963592,0.06257579,-0.0063492884,0.020113114,0.12723394,0.05448985,0.0735276,-0.14509572,0.052765235,0.037866946,-0.083880335,0.017082796,0.0043994524,-0.01502075,0.021235833,0.06792043,-0.037344925,0.03941139,0.007857705,-0.044124797,-0.037830763,-0.03447863,-0.09366657,0.029101837,-0.007065031,0.09704218,-0.023295807,-0.037372243,-0.020006903,0.049435228,-0.05644604,0.06257315,0.035389178,-0.02246485,-0.06557624,-0.06063385,-0.006421473,-0.06254991,-0.08207211,0.047421727,0.0008761568,0.0074525042,-0.042102545,0.082728095,0.018583221,0.07191901,-0.11013962,0.02479401,0.072445676,-0.0044769,0.083002485,-0.03128585,-0.036268312,-0.011446964,0.062795036,0.042364884,-3.241394e-08,0.089613594,-0.027989062,0.07332696,-0.09770646,-0.07139767,-0.019861253,-0.04849652,0.00909786,0.05487355,-0.055313878,0.06936521,-0.009825473,-0.007527318,0.06062631,-0.019037139,0.05176339,-0.045717202,0.00077099516,0.036591478,-0.010569103,-0.08789892,0.029000718,-0.042273838,-0.02663548,0.023663474,-0.02399665,0.019809078,0.058163796,-0.0075997873,-0.046718754,0.039898742,-0.029898617,-0.039409682,0.03838087,-0.05882004,0.04450368,-0.0011988844,-0.064324364,-0.0024572255,0.01398739,0.0044817897,0.017564287,-0.07161307,0.023118831,0.0053723427,-0.0069388677,0.03649869,0.040525284,-0.046421476,-0.05121936,0.05538222,-0.061963078,-0.058291953,-0.05727124,-0.12652275,0.0035588725,-0.027706996,-0.04515666,-0.023603166,-0.033459,0.010172355,0.015813421,0.15069118,0.10757228 +3.4.24.76,"A zinc metalloendopeptidase in peptidase family M12 (astacin family), secreted by the bacterium Flavobacterium meningosepticum . The specificity is similar to that of EC 3.4.24.33, peptidyl-Asp metalloendopeptidase from Pseudomonas fragi but the two are reported to be structurally dissimilar",384,1.0,-0.09213985,-0.06751017,-0.13640815,0.08708284,0.08351384,0.040182754,-0.007073733,0.06408969,0.025974113,-0.030025646,0.02446841,-0.06906846,0.03104254,0.036190234,-0.079688266,-0.09631559,-0.018252594,-0.023768978,-0.03133974,0.030511836,0.1122611,0.036054466,0.0070336396,-0.05769505,0.005863328,0.016372213,-0.0050537717,-0.07189647,0.0037506395,-0.023319334,0.036413077,-0.043306775,0.07076981,-0.053449146,0.13739082,0.007828668,0.024123203,-0.029604824,0.10211254,-0.017575799,0.05053399,0.08813149,0.029213043,-0.051689815,0.007891816,-0.002023472,0.025346074,0.04997124,0.051775422,-0.0044348203,-0.016723005,-0.049703933,0.020882702,0.0021931946,-0.007986734,0.09815697,-0.0027985158,-0.035031516,0.028063245,0.029279683,0.094021626,-0.04253699,0.048221134,-0.01966224,-0.027733319,-0.014229746,-0.026878776,-0.033796247,0.07394659,-0.018967493,-0.009106475,-0.026769282,-0.02345918,0.06788384,0.028979924,0.099035464,0.02052615,-0.051879875,-0.03863103,-0.050993286,0.027053751,-0.003332619,0.12476594,0.037984714,0.037457738,-0.0021973716,0.03896377,0.017804304,0.0077197407,0.05014525,0.009150671,-0.0058905263,0.02769228,-0.023308767,-0.089227885,0.023278626,0.02682273,0.052175112,-0.016855506,-0.011702234,0.04816186,0.050346762,0.015517728,-0.071900144,0.045082502,0.03516365,-0.032114945,0.05240086,0.100409515,0.012383668,0.007802974,-0.023883,-0.034458596,-0.08699431,0.04511921,-0.015109875,0.021312263,-0.038320493,-0.060784712,7.634758e-05,0.031919286,-0.016481867,-0.016088782,0.0048227333,0.043065228,0.008913494,-0.14644988,5.4107123e-33,0.004936581,0.060572222,0.034580298,-0.0360503,0.050704874,-0.014579807,-0.008611575,-0.025565097,0.06072163,-0.034637168,-0.093872495,-0.10953538,-0.05424713,-0.054363526,-0.08745549,-0.047048245,-0.106977455,-0.031740274,0.03781854,0.012621299,-0.007738789,0.07089834,-0.03326822,-0.037908558,0.124604136,-0.010432292,-0.02473811,-0.06694177,0.07429441,-0.013493802,0.007737556,-0.024968063,-0.114880316,-0.031222492,0.089490354,-0.069302805,0.03851404,-0.10288535,-0.04493967,-0.0427654,-0.044632465,0.02994737,-0.05163648,0.028061023,0.082468726,-0.042751636,-0.06262416,0.098288044,0.045268122,0.00328369,-0.0149633065,0.003241498,0.1434955,-0.0008228827,-0.061461646,0.006005815,-0.015992295,0.061429415,0.14269155,0.06635484,0.09118703,0.041027404,-0.042112462,0.012538168,0.002960806,0.04558445,-0.04843425,-0.004074822,0.039773118,0.06714704,-0.06658415,0.001973816,0.032765467,0.046646923,0.024208583,-0.07227042,-0.069168776,0.029609472,0.047133334,-0.021930838,-0.027882626,0.0114745,0.061056416,-0.014166877,-0.072158374,-0.0056234635,0.046450563,-0.021281099,-0.033570312,0.017915906,0.058443997,-0.013796872,-0.030743867,0.054354984,-0.05429137,-4.4311152e-33,0.06992123,0.022867663,0.024786092,-0.030695196,-0.05187579,-0.0075612348,-0.07697836,0.019913878,0.021778641,-0.077414036,0.109812535,0.026983913,0.059219256,-0.04987788,0.024965826,0.014401179,0.024196431,0.0639556,0.0024837623,-0.0040328964,-0.0006154221,-0.020682657,0.0025830213,0.009114268,0.05911203,0.009152889,-0.011413487,-0.0016290796,0.0074860225,0.067260355,0.038489774,0.13158935,-0.04665695,-0.15000841,-0.11879252,-0.050925307,-0.07877719,-0.03528236,0.046186544,0.0019688841,0.018630577,0.007219322,-0.034441356,0.084246956,0.014492245,0.05637815,-0.057664163,0.016906513,0.018254738,-0.05787835,-0.04130662,-0.03766963,-0.032347266,0.005682443,0.03887523,-0.00023675522,0.018075423,0.022898339,-0.031766426,-0.0029821142,-0.026970869,0.0025347506,0.0056424206,0.035702873,0.080704905,0.06060661,0.030180916,0.06079543,0.040140092,0.020841382,0.03219544,-0.0024266595,0.007864856,0.051250648,0.013968766,-0.0055849073,-0.02233495,-0.026010951,-0.029833838,0.027432099,0.028491654,0.014256547,0.017921623,-0.027309798,-0.0006498106,-0.099178225,0.037838854,0.10026331,-0.05583304,0.033237837,-0.053854436,-0.07966771,0.026932452,0.03386067,0.012490133,-3.6205833e-08,0.009939387,0.0077676093,0.051395357,-0.09896476,0.00988894,-0.038595892,-0.055693146,-0.05611465,-0.012619412,-0.060368087,0.018557223,-0.02535093,-0.014775997,0.0020412952,-0.011252066,0.049831398,-0.06761231,-0.0017637241,0.012733595,0.05137677,-0.065518245,0.019736405,-0.111596406,0.033962663,0.058431417,-0.037495647,0.045809876,0.035537954,-0.037018333,0.052064914,-0.037307445,-0.015549867,-0.008150071,0.029937506,-0.08023333,-0.015455018,-0.040405195,-0.008988203,-0.019401968,-0.059501704,-0.032699488,-0.06609684,-0.0016224359,-0.0037400052,-0.029838918,-0.009284662,0.024815567,0.06042783,-0.030400217,-0.065434106,0.02014165,-0.05909271,-0.02547928,-0.048727553,-0.06525262,0.020332798,-0.008737428,-0.015446985,-0.05063346,-0.04850448,-0.08830603,-0.0321129,0.17497383,0.023808615 +3.4.24.77,Type example of peptidase family M7.,384,1.0,-0.029692234,-0.057130527,-0.06470448,-0.006265735,-0.0011083392,0.054815345,-0.0028557118,0.05987549,-0.014314067,0.04400034,0.07606788,-0.05141459,0.009512992,0.05405878,-0.016865756,0.014869428,-0.055572737,-0.042710315,0.0063056303,-0.03416695,0.042187616,0.055019073,0.021246096,0.08790311,-0.06929031,0.01557892,0.05624466,0.03681132,0.0747423,-0.0959294,-0.038761634,0.013293742,0.08713314,-0.014486425,0.084606506,0.0036181433,0.009710139,0.031565245,0.062835366,0.00827753,0.047394864,0.032191798,0.091837965,-0.1011177,0.029742977,-0.029433157,0.011096151,0.08098184,0.04747857,-0.058671314,-0.04038684,-0.0785526,-0.08067902,0.0385364,0.031998523,-0.015540205,-0.10860397,-0.07116835,0.047151133,0.016553523,0.020965876,0.00930823,-0.030110784,-0.048542425,-0.056761313,0.005039928,-0.0063763,-0.014997231,0.033809956,0.0016070288,0.019770103,-0.088230185,-0.04858443,0.10598613,-0.046051733,0.05388617,0.041048385,-0.047100052,-0.11174063,-0.02878111,-0.10486126,-0.00090241776,0.09807913,0.041181404,0.030111382,0.002926371,0.057360668,0.028077472,-0.006178453,-0.031490292,0.08568116,-0.06924066,0.07775364,-0.025310038,-0.05591878,-0.011361484,0.030810181,-0.03277455,0.012497234,0.041115,0.04060577,0.0077451244,-0.0023058194,0.019024944,-0.014987629,0.055165797,-0.048636425,0.020593936,0.047525756,-0.031579264,-0.07292664,-0.018962374,0.0029228139,-0.06842717,-0.042062484,-0.07155826,0.0007839497,-0.006041865,0.034846786,0.038143244,0.0515211,0.007845628,0.05682344,0.016871387,-0.027280085,0.021028187,-0.086270824,1.7914506e-34,-0.00088442356,-0.06932179,0.08634359,0.04137457,-0.012675924,0.019923847,-0.05286532,-0.02675865,0.061361257,-0.10199141,-0.0775639,-0.030345187,-0.032514643,0.013339892,-0.07514924,0.05225111,-0.07276609,-0.018754642,-0.0077693006,0.06164053,-0.0354811,0.19196981,-0.014269602,-0.06606735,0.07871044,0.09166475,0.08436853,-0.008752611,0.031730555,0.0032809174,-0.06002741,-0.0063982974,-0.079881534,-0.020361552,-0.06275213,0.013840099,0.003547652,-0.09543298,-0.01008152,0.021135993,-0.005519311,0.018041693,-0.0063108206,-0.02741009,0.07978871,-0.0071656937,-0.02599331,0.026248869,-0.041302685,0.037734553,0.035876773,-0.017378898,0.022127002,0.034222092,-0.048803892,0.03510533,-0.0014150974,0.065554015,0.11585448,0.06687624,0.07598803,-0.002417705,-0.00071385264,0.014238266,-0.009301094,0.0155640645,-0.10858992,0.011433472,0.01590286,0.089920096,-0.0074548,0.008799058,0.022156285,0.05367785,0.03551538,-0.09751428,-0.039033357,0.012649136,-0.0779221,0.023915477,-0.0048809187,-0.020150833,0.02631582,0.03741644,-0.08716159,-0.016120112,-0.001730949,-0.03915356,-0.021882752,-0.02527274,-0.024807964,0.001434536,0.00056670606,0.063002326,-0.09161087,-1.1267454e-33,0.03874771,-0.0015286139,0.01026028,-0.0007129508,-0.06824108,0.012616498,0.04493746,0.03022875,-0.02849164,-0.062067185,0.03862534,-0.008463987,0.049238946,-0.07752352,-0.012507785,0.01867736,0.025912596,0.07046101,-0.01517638,-0.0235477,-0.103637315,0.024357747,-0.05051094,-0.00085483456,0.0057214946,0.011363141,-0.07487939,0.049651522,0.034221467,-0.025634615,-0.006709468,-0.0013101363,-0.03081118,-0.028749386,-0.08158224,0.008880464,-0.05193632,-0.0010888051,-0.022162907,-0.018299947,-0.0105984695,0.07330338,0.094310105,0.08834067,-0.005550119,0.052686736,0.038649328,0.001016219,0.063111685,-0.023289206,-0.022424983,-0.07987646,-0.01527355,0.0016319719,0.04105305,-0.08413076,0.05584753,0.01781811,-0.021980282,0.064563364,0.05165555,-0.057623904,-0.021043817,0.010908209,0.054705154,0.025689086,-0.16049056,-0.03025345,0.045629513,0.0031729797,0.03638494,-0.03918757,0.013047768,0.009593566,0.04949048,0.038406704,-0.072798654,-0.04131888,0.011378876,-0.06061306,-0.029443422,-0.065986454,-0.03733661,0.01460325,-0.048751548,-0.04206672,0.0495329,-0.01010847,0.07098504,0.061542436,0.030911127,0.009149108,0.0520511,0.09539526,0.040090196,-1.8350097e-08,0.09736233,-0.13954173,0.053150613,-0.049466994,-0.07108195,-0.04985971,-0.0555843,-0.010992269,0.01905622,0.02908301,0.0075107715,0.032886807,-0.0073747374,0.07684867,-0.003489356,0.07927549,0.015145416,0.014248562,-0.0053331107,0.051182445,-0.09598439,-0.0051394226,-0.023190225,0.0077883117,-0.015355681,-0.054692566,0.038538303,0.091789275,-0.0049729915,-0.046306692,0.02398191,0.003936817,-0.01046992,-0.050967477,0.009017513,0.07028423,-0.03297404,0.005514749,0.047594637,-0.04166658,0.06757089,-0.08421356,-0.08695663,-0.03819409,0.05150054,-0.036460403,-0.029027356,0.010145471,-0.060978178,0.014404161,0.036540814,0.063367106,0.011824606,-0.076921314,-0.08345539,-0.0014713324,0.006856352,-0.02973746,0.09589172,-0.109679975,0.09339289,-0.017293358,0.12951665,0.05734835 +3.4.24.78,"Initiates the degradation of small, acid-soluble proteins during spore germination in Bacillus megaterium. Type example of peptidase family A25.",384,1.0,-0.017512491,-0.055847697,-0.011076365,-0.089499965,0.07781036,0.0035776696,-0.07388116,0.050383646,0.010976504,-0.028290704,0.068399064,0.02622889,0.07439208,0.052578915,-0.0035260646,0.027683588,-0.0397251,-0.03382337,-0.03852816,-0.04579065,0.10267138,0.033900067,-0.13555099,0.059144504,-0.03216449,-0.07864643,0.037166208,-0.12214693,-0.032443143,-0.027072096,0.0030671412,0.013291987,0.09223553,-0.04832561,0.054494575,0.05863429,-0.006636325,0.0070513594,0.1213371,0.0049810368,0.06511211,0.05222797,-0.017386599,-0.058269992,0.01647048,0.041037735,-0.008776322,0.046406206,0.031019537,-0.047496457,-0.08290243,-0.025149103,-0.003189408,-0.04646826,0.017993258,-0.024500482,-0.046826914,0.0033418504,0.01647741,0.015164734,0.00024062068,0.008708117,0.05537224,-0.046870366,0.012945277,-0.05604254,0.022724342,-0.049965285,-0.0036564965,0.037822347,-0.028003827,0.010083036,-0.004555176,0.06417856,0.027089503,0.060449038,-0.090933174,-0.01705351,-0.08261244,0.017837523,-0.03169222,-0.02596155,-0.012403303,0.059079,0.016073722,-0.0052001383,0.073715046,-0.018001726,0.025940124,0.0072677457,0.057515822,-0.010608423,0.0614034,0.043288447,-0.076163016,0.0038541874,-0.0108959405,-0.12590812,-0.020325357,-0.01945022,-0.013668384,-0.0378767,-0.012564031,-0.059615046,-0.0197311,-0.0044255164,-0.0022148115,0.087710425,0.07458546,0.05914564,0.0473974,0.007279952,0.04131576,-0.060919072,-0.006107935,0.023262154,0.0012823396,-0.0057427716,-0.040466603,-0.057105426,0.009514694,0.008356879,-0.02769937,-0.0012058886,-0.019094132,0.0035707855,-0.04329181,2.6774663e-33,0.00032611148,-0.116124086,0.056258723,0.097125486,-0.0543364,-0.009865793,-0.038661007,-0.01228825,0.05369378,-0.10259829,-0.03209228,-0.10499973,-0.035730846,-0.004060583,-0.06299525,0.044507373,0.0036111227,0.025910432,0.010144619,0.06787048,-0.0029267448,0.024309453,-0.012980645,-0.041825604,0.13042356,0.023570722,0.067537725,-0.12589599,0.015509943,-0.01642145,0.0029579506,-0.08544814,-0.15879966,0.04892488,0.019100782,-0.043662183,0.030385356,-0.0037632135,-0.047264587,-0.0035728756,-0.041016668,0.070277624,-0.008640354,-0.026509367,0.05801766,0.044473965,-0.0037700587,0.08478429,-0.015962176,0.0002653224,0.028011791,-0.0029014777,0.08019199,0.031334497,-0.058030337,-0.018246973,0.04784673,0.021759145,0.04606229,0.0048431186,0.07817084,0.07454535,-0.03829221,0.07551997,-0.006317109,-0.016184697,-0.061001413,0.0148167685,0.07327273,0.05314151,-0.035332453,0.043022253,0.08223444,-0.019291123,-0.05577314,-0.13467447,-0.04580298,0.033551227,-0.020910053,0.06805197,0.065590315,-0.11132575,0.006662871,-0.020190543,-0.10274621,0.025319453,0.012058364,3.5336075e-06,0.01360351,-0.0019778064,0.0619721,-0.064418286,-0.047474533,0.092805795,-0.10627387,-1.93472e-33,0.11229826,-0.06927688,0.09958706,-0.004470386,-0.07269646,0.0152622955,0.025025953,0.031120894,-0.021937132,-0.08325264,-0.05663691,0.066174045,0.043101784,-0.04145929,-0.011946807,0.059316594,0.019088607,0.04310505,-0.006062172,-0.014396316,-0.068144605,0.058588404,0.005453896,-0.036540244,0.038924474,0.03245592,-0.005067524,0.12442214,0.020144252,-0.04178586,-0.0007856696,0.0755424,-0.015080369,-0.07269899,-0.07313018,0.002655937,0.021703644,0.004633736,-0.00039441482,-0.024530172,-0.09551678,0.07113099,-0.0034938094,0.017799772,0.017494714,0.08013188,0.052389972,0.0077526304,0.07111953,-0.0070277974,0.034306727,-0.09178115,0.022939507,-0.028790137,0.020723404,-0.0909364,-0.04616566,0.09460675,-0.07767902,-0.028520003,-0.015123387,-0.0076572653,0.025604347,0.065146364,-0.047148272,0.06092969,-0.011839311,0.054560196,-0.007118144,-0.0113630025,0.03408196,0.051264096,0.07223319,0.04749171,0.0014795542,0.03637348,-0.10312446,-0.019948741,0.018522345,0.039097495,-0.088593885,0.0110643525,-0.044975165,0.019873811,0.03798622,-0.0015042772,0.014747328,0.032179233,0.016055662,0.014977381,-0.0405131,-0.07172189,0.075257905,0.050848074,0.06746611,-2.5528223e-08,0.07015207,-0.064398274,-0.058005806,-0.008894531,-0.0043144496,-0.06106119,-0.034952037,0.033438005,0.06899367,-0.03285058,-0.056561343,0.008673313,-0.06698746,0.053081516,0.02324285,0.04561248,-0.04867263,-0.050232228,0.0037510528,0.03495184,-0.060788624,-0.037165094,-0.08273758,0.047270186,0.090217136,-0.03164105,0.056643873,0.03267578,0.0066098697,-0.031351484,-0.0003474571,4.67974e-05,0.00571726,-0.015860751,0.043251596,0.023590563,-0.06483093,0.06768755,0.10246355,0.07043783,0.0047268616,-0.06291299,-0.04291241,-0.08164774,-0.024912456,-0.0012499875,-0.0946339,0.019622954,-0.007170219,-0.017666053,0.044607468,0.0036168469,-0.031712424,-0.0015851699,-0.0405611,0.028153684,0.024453726,-0.0505842,0.04615801,-0.038168497,0.012266993,0.037701663,0.09908776,0.012105968 +3.4.24.79,"A 400-kDa disulfide-linked dimer. Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. In peptidase family M43.",384,1.0,-0.01754497,-0.0037287546,-0.030155921,-0.014141784,0.08264207,-0.013025302,0.031797595,0.16061354,0.042958044,0.07759872,0.008962533,0.012149125,-0.052866284,0.051850636,-0.03366976,0.08049757,-0.024966227,0.00058265816,-0.021029279,-0.07939506,0.0322154,-0.037352752,0.008635714,0.024482056,-0.003948163,0.03013009,0.06861985,0.06144256,0.001771897,-0.054801565,0.006276311,-0.0105958665,0.029971242,-0.068191476,-0.053230487,0.07689393,0.0060737273,-0.03519502,0.027521998,-0.02081667,0.1009048,0.0102024395,-0.06762673,0.0688899,0.043722548,-0.05397488,-0.057492536,0.14509083,0.0006622413,0.0027273423,-0.01856779,-0.037589736,-0.022842573,0.08763225,-0.00032516927,-0.07157818,-0.11656598,0.032613326,0.04661309,-0.021792164,-0.025553856,0.06929445,0.0576411,0.0068132305,0.022731278,0.017504528,0.079905346,-0.034982473,-0.0031452395,0.026826186,0.015492034,0.03198129,-0.010410469,0.103388995,0.046770304,-0.011861013,-0.085460246,-0.004956975,-0.025840031,0.00049434754,-0.010356823,0.07066387,0.10141252,0.007244506,0.0028210124,-0.0018516616,0.06768023,-0.02429662,0.006149591,-0.00039380646,0.021007318,-0.060578838,-0.033692818,0.05084633,-0.04048247,-0.03000253,-0.10287093,-0.096436225,-0.0013342242,-0.0029452378,0.04475888,0.057876926,-0.07514228,0.002416553,-0.047697626,0.034385152,-0.04015623,0.09250533,0.022403931,0.041807733,-0.0035589042,-6.7650944e-05,0.02603431,0.059457794,0.03092309,0.009489507,0.03563587,0.0020803525,0.04700354,-0.033952948,0.014130408,0.033325363,-0.010281392,0.025689058,-0.110300705,0.00659063,-0.032300863,2.5046572e-33,-0.043170463,-0.10759081,0.07420006,0.12575747,-0.03213154,0.090926304,-0.0066450853,-0.06418601,0.007227264,-0.078626886,-0.114421405,-0.06080634,0.020472677,0.007239544,-0.037001245,0.0218403,-0.0016289984,0.07769241,0.09296348,0.07905259,0.0034407738,0.08488333,-0.048558384,-0.12640904,0.06872792,0.075988315,0.015416931,0.040333636,0.05810573,-0.008317121,-0.0865402,-0.010893594,-0.05784319,-0.035952114,-0.017699718,-0.022233848,0.0038350977,-0.08145803,0.02365161,0.0415975,-0.073210604,-0.044526,-0.012201754,-0.0918726,0.062492326,0.008714222,0.03159837,-0.0412896,-0.09389117,-0.105279215,0.047102757,0.012932915,0.087424114,0.017054055,-0.042160966,0.0036806006,-0.029382486,-0.05653226,0.06104285,0.05016926,0.0054630926,0.036604073,-0.07894351,0.058582522,-0.088604584,-0.103992164,-0.022290455,-0.04138337,-0.060350385,0.12696397,-0.032007523,0.0046067145,0.11711646,-0.003573961,-0.014645806,-0.062560916,-0.01774788,0.07700654,-0.029534915,0.05101875,0.03286328,-0.02690987,0.053911652,-0.026756262,0.017057221,-0.038802918,0.03304705,-0.0040847813,0.01899613,-0.0020371617,0.024168741,-0.07412629,-0.037755694,0.026537053,0.037460864,-3.389266e-33,0.077459335,-0.06825559,0.07856018,-0.030695293,-0.058869813,0.045532253,0.08074315,0.03337073,0.05493003,-0.030181283,0.09928964,-0.04573507,0.008338259,-0.087478675,0.07483801,0.029369634,-0.03374171,0.042216577,-0.028736424,-0.01393601,-0.06369099,0.020534752,0.013543087,0.029975694,0.024021063,-0.012549002,0.015584529,0.07075343,0.009638768,0.007187445,-0.030593224,-0.0131561905,-0.102520205,-0.04296354,-0.028547496,-0.03197047,-0.08423616,0.009028646,-0.015106426,-0.114541665,-0.011755079,0.100675575,0.026812749,0.017077757,-0.046570867,0.08059374,0.03886968,0.08535206,0.03889259,-0.04943835,-0.062995195,-0.06607841,-0.049914993,0.02959208,0.0081719225,-0.02955324,0.0602109,-0.023786757,0.012580375,0.07711912,-0.036124717,-0.044140484,0.049912255,-0.019579433,-0.008973273,0.023480223,-0.04154431,0.031083917,0.05603903,0.0489266,0.05397717,-0.016343025,0.031292506,0.012129878,-0.029547965,0.012712646,-0.055574574,-0.020701349,-0.0054134014,0.030698262,0.010263707,-0.07525392,-0.029230705,-0.09660994,-0.033780742,-0.08948194,0.039874237,0.071697876,-0.00883656,0.055129915,-0.011052578,0.008366665,-0.061982162,0.007769112,0.035719752,-4.4981288e-08,0.04988739,-0.05697249,-0.0031395766,-0.049873006,-0.08968632,-0.08408466,0.021403244,0.028522605,0.030358644,0.02166477,-0.0014704083,0.0017638128,-0.009476859,0.011278658,-0.012605815,0.0569976,-0.0014407446,0.029844597,0.040165678,-0.080390304,-0.03976614,-0.028012348,-0.00969648,0.029102962,0.013106024,-0.0044086576,0.057515904,0.02976835,-0.02519427,-0.03684444,0.0504829,-0.04473612,-0.011692585,0.034809362,0.011112119,0.041096732,-0.055796057,0.043068882,0.0032961105,0.0048527,0.021076899,-0.084179685,0.024306918,-0.020425336,0.012903182,0.0014975135,-0.012694109,0.017089427,-0.033978455,-0.023629047,-0.0033051518,-0.03795177,-0.047300022,-0.06572728,0.0092872195,0.03131866,-0.06771528,-0.070161395,0.02815148,-0.07740747,-0.046690166,-0.057635248,0.14505629,0.027648235 +3.4.24.80,"In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.",384,0.99999994,-0.07739571,-0.035851043,-0.06034473,-0.08151894,-0.014044787,0.08679358,0.051868983,0.08774103,0.061505526,0.026565157,0.053509757,0.039697334,0.024849385,0.067120224,-0.03131816,0.038279764,-0.03322142,-0.017247822,-0.06643246,-0.03835615,-0.029203832,-0.01296033,0.052874967,-0.020877572,-0.06876166,0.0018250701,0.038555324,0.0039849114,0.03648152,-0.06549178,-0.012654582,-0.034919918,0.08782909,-0.010875024,0.09644459,0.060428962,-0.0121444855,-0.011062179,0.04151334,0.00063935755,0.10618323,0.040207367,-0.006249141,-0.06226962,0.039688144,-0.011724491,0.032243863,0.07063611,0.035211116,0.010428221,-0.052166823,-0.03582548,-0.021283716,-0.011476285,-0.06867589,0.10676244,-0.019310404,-0.03500012,0.054513607,0.011676171,2.0171817e-06,-0.0050616884,0.02149858,0.011634885,-0.010421387,-0.11195269,0.018541863,0.02987155,-0.036093563,0.0843403,0.024701864,-0.043556903,-0.05720985,0.041051645,0.0002766161,0.019233929,-0.029613687,-0.045360174,-0.09021065,-0.012598394,0.022565108,-0.03822146,0.06519675,0.07020558,0.0028643245,-0.0013235221,0.1326776,-0.034328222,0.00864292,-0.03509505,0.017273664,-0.11041312,0.0076595847,0.07708839,-0.094451904,-0.004702794,-0.0030098432,-0.027100965,-0.053354505,-0.0030769983,0.033603743,-0.034810927,-0.011484465,0.0018758846,0.009349008,0.03394665,-0.03835318,0.0699108,0.03869133,-0.01240501,-0.027443198,-0.05238096,0.005729424,0.025497088,-0.021356896,-0.010729964,0.015004106,0.0033734522,0.047754984,0.019373681,0.0024940372,0.0411345,-0.009165732,0.04656408,-0.031391207,0.07569044,-0.10030776,-2.660376e-34,-0.0022882088,-0.021352325,0.008354786,0.040568836,-0.072300285,0.004931239,-0.08228238,-0.0482092,-0.017152531,-0.10723581,-0.12496614,-0.055431824,0.006328618,0.023883874,-0.111358725,-0.0019157112,-0.06521603,0.0063887187,0.020640543,0.014127395,-0.06451569,0.06707545,-0.028685754,-0.08796631,0.081659816,0.009078782,0.064993516,-0.030263191,0.04000968,0.0041670967,-0.0006143783,-0.035186823,-0.079966895,0.004656379,-0.010764024,0.067197934,0.07020415,-0.12768419,-0.00589234,0.0027852335,-0.12709787,0.043962676,-0.0152664315,-0.04086221,0.06636401,-0.06460227,-0.03845587,0.09749845,-0.023929577,-0.017512925,0.040328454,0.02263015,0.087007575,-0.019348262,-0.065193176,0.037333127,-0.013312803,0.043220486,0.104213245,-0.019330343,0.05587311,-0.024681903,-0.05000868,0.05352886,0.03040157,0.12185411,-0.047069,0.003145795,0.03580791,0.10570735,-0.043104295,0.023897827,0.08157599,0.07230222,0.031075887,-0.06335752,-0.04188683,-0.029627454,-0.033568297,0.08289873,0.04386662,-0.031156605,-0.03315309,0.017195646,-0.09237899,-0.10001371,0.037073646,-0.0032097911,-0.038638208,0.020490887,0.07592642,-0.0076564956,-0.029926084,0.07220831,-0.08589849,-4.01458e-34,0.057133086,-0.06511489,0.09391288,-0.036901753,-0.022184981,0.013183117,-0.001245388,-0.00017746686,-0.007914666,0.003060117,0.017249843,-0.0102952,-0.021351889,-0.041093253,-0.028369315,0.009647798,-0.019319635,-0.003524628,-0.0451588,-0.04440688,-0.067401215,0.0368215,-0.027577968,0.11533523,-0.05078275,-0.0008909411,-0.04674009,0.06787842,-0.0024139478,-0.025791632,-0.020354958,-0.01279703,-0.047722258,-0.0046467585,-0.043189388,0.11099398,0.008196667,-0.0077703474,-0.022939917,-0.05095014,-0.004334216,0.056894686,0.029793309,0.082344316,0.018183637,0.12972263,0.025034115,0.03949698,-0.03512592,-0.030492933,-0.070175625,-0.017007872,0.030727448,0.021329248,0.07549034,-0.015880376,0.02174611,-0.012522308,-0.06423851,0.012241889,0.048772696,-0.022788255,0.039422903,0.02601086,0.02200256,0.06215161,-0.107121125,-0.012610247,0.06168491,0.061878845,0.04418009,-0.011470084,-0.0031663596,-0.008479917,0.019891458,0.115686715,-0.1023276,-0.1044438,-0.020868786,-0.04790751,-0.027492175,-0.06721438,-0.032387212,-0.013553867,0.041210122,0.0018762539,0.019565366,0.040175706,0.029353954,0.036450118,0.052771937,-0.060174692,-0.014803684,0.05334358,0.005446689,-3.0345458e-08,0.09449815,-0.005970359,0.066904746,-0.09875634,-0.07301773,-0.017648576,0.003020721,-0.0037460313,0.080871515,0.0076591894,-0.06040147,0.021323971,-0.040721804,0.040139806,0.036421467,0.120139495,-0.018448196,-0.035357293,-0.013851793,-0.015725281,-0.06552788,0.030018311,-0.0617845,0.050177563,-0.048381742,-0.04648645,-0.003616322,0.04725405,-0.038487915,-0.046875685,0.010679091,0.0152992,-0.040260896,0.009955753,-0.008875208,0.09018267,0.015631339,-0.00059594744,0.013468399,-0.010604485,0.11309542,-0.0962557,-0.032701626,-0.04250127,-0.003802624,0.042017125,0.017439999,-0.00096084794,-0.060336024,0.03900935,0.007294095,-0.01308626,-0.022814177,-0.05513021,-0.09843637,0.060939543,-0.050460797,-0.052503556,0.026076607,-0.035139743,-0.00313292,0.029082913,0.15127341,0.011003023 +3.4.24.81,"In peptidase family M12. Partially responsible for the ""alpha-secretase"" activity in brain that degrades the potentially harmful beta-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling.",384,1.0,-0.05231403,-0.052428022,-0.040063377,-0.042574983,0.021459,0.044978544,0.0406674,0.04320632,0.011349052,0.07220725,-0.035600197,0.022761775,-0.08444861,0.040271964,0.013320082,0.06008233,-0.13664857,-0.011662177,-0.0016720794,-0.047686066,-0.04304569,0.028188707,0.008130592,0.008031032,-0.022545328,0.02731196,0.06388234,-0.05689048,0.0373991,-0.04230679,0.03466803,-0.066630274,0.017643113,0.018842557,-0.01762998,0.00086523785,0.01644035,-0.03414501,-0.0840699,-0.036681786,0.082935475,0.0120078055,-0.007325679,-0.03465415,0.01897793,-0.0018260285,-0.0055017513,0.044081535,0.04814174,-0.0062724478,-0.019890614,-0.067771,-0.0014601456,0.011205286,0.003695727,0.07904542,-0.06830492,-0.0064959093,0.036954507,0.10688375,-0.039125998,-0.045205288,-0.008585389,0.0012959404,0.014439493,-0.0042152214,-0.014765892,-0.03849392,-0.06205092,0.027675789,0.0898303,-0.072593376,-0.074422285,-0.021104068,0.01650765,0.050842933,-0.024165835,0.0027091017,-0.0034331628,0.0040659574,-0.034561865,-0.006123267,0.09284193,0.087159194,0.0501175,0.04481187,0.06749565,-0.053105876,-0.08205332,0.08380437,-0.0026862272,-0.1141911,0.06304145,0.06996359,0.0019256872,0.00086544594,-0.011665266,-0.05171777,-0.03508394,0.051424623,-0.04254981,0.049790595,-0.040875778,-0.038957495,0.0073068035,0.11645361,0.046990152,-0.053509332,0.03443682,0.012057528,0.028159048,-0.023699671,0.029942004,0.0076307976,0.02771003,-0.060173575,0.0022453242,0.0034618806,0.067532144,-0.0073984126,-0.022035053,0.015843041,-0.024906242,0.051629767,-0.06007436,0.088977836,-0.09975419,1.086885e-33,0.060760252,-0.009208312,-0.021130024,0.021182323,0.016485814,0.062431,-0.13777336,-0.0065894034,0.008995008,-0.02111235,-0.08414188,-0.12138677,-0.012413154,0.08853895,0.0063840733,-0.017471546,0.027134577,-0.010155404,0.059250988,-0.027649464,-0.11042475,-0.024910087,-0.014591137,0.012934803,0.028292831,0.05911056,0.021149656,-0.010741884,0.08141261,0.014567851,-0.0714579,0.02747121,-0.09238824,-0.012604557,-0.041358292,0.027527047,0.113311,-0.051485855,-0.09919751,0.023387995,0.06308389,0.011146175,-0.07243489,-0.021312486,0.02103822,-0.091284044,0.051911782,0.06000022,-0.0031508247,0.0043530036,-0.023060538,0.049867827,0.076970875,-0.016659569,-0.086173095,-0.030665182,-0.012450972,-0.025342079,0.09474875,-0.001706858,0.010936374,-0.0029039765,0.019312965,0.05041672,0.005081915,0.06869813,0.04350277,-0.07431582,0.01500442,0.015731571,0.0024194766,-0.06849806,0.06366824,-0.036147084,-0.025028938,-0.053421937,-0.014608899,0.0014622415,0.07451063,0.029941687,0.05833605,0.037170924,0.007025193,0.053065896,0.024967544,-0.064946994,0.016922781,-0.022429688,-0.050130915,0.008962786,0.051039398,-0.022861129,0.058765717,0.10326356,-0.093610324,-2.4140182e-33,-0.03739921,-0.109665155,0.022164082,-0.12340742,-0.04821315,0.06970145,0.0041316045,-0.015219774,0.06983803,-0.026333634,0.07698236,-0.019394387,0.009240655,-0.054548226,0.06840096,-0.070956744,-0.025665311,0.021481195,-0.017102255,-0.058835287,0.039113775,0.039692186,-0.030679889,0.06522516,0.032296076,-0.0077148965,-0.0003077679,0.080256626,-0.027031772,-0.019433161,-0.06151297,0.04059465,-0.09561924,-0.04618966,0.020325916,0.054804184,0.006564129,0.041431602,-0.08825858,-0.10150122,0.050368965,0.09991295,0.071418144,0.05665243,0.043211546,0.036572084,0.011697035,0.03794497,-0.094993226,0.05948428,-0.033455506,0.046494834,-0.016901484,0.0051419483,-0.049182236,-0.032110352,-0.036689274,0.038771745,-0.032984298,0.046343677,-0.019778578,-0.07391117,-0.003278346,0.122503385,0.040007014,0.03196504,-0.04275157,-0.009976842,0.009634947,0.014468017,0.04016722,-0.014008017,0.07400034,0.023670986,-0.00051083416,0.034124292,-0.069246344,-0.051256977,0.046687514,-0.0057937144,-0.017696217,-0.015064645,-0.0393213,-0.004301118,0.023905106,-0.029020747,0.010025618,0.11083071,0.018578686,0.018744884,0.024931705,-0.07587409,-0.101931654,-0.03916675,-0.08475173,-2.9686442e-08,0.065747604,-0.023262661,0.035014626,-0.053829588,-0.00078891875,-0.056436695,-0.024073523,0.050187,-0.040698644,-0.029820602,0.035014994,0.037622288,-0.066244565,0.06516206,0.02268979,0.07098244,0.015054671,0.09782995,-0.0063341367,-0.051692262,-0.072578125,0.05651719,0.020764336,0.012197021,-0.07972124,-0.1311917,0.0061904285,0.12639825,-0.051819716,-0.041761983,0.03908713,0.05441474,-0.009208192,-0.013319938,0.0151040815,-0.022789378,0.06431828,0.0503203,-0.003333638,-0.012504534,0.042297523,-0.071282215,0.013145972,-0.0497461,-0.076322295,0.018088693,0.080275536,0.02634933,-0.0021521228,-0.017133996,0.03330989,0.06972605,0.0039319294,-0.06737613,-0.10634557,-0.05442272,-0.011335672,-0.06337423,0.019661361,-0.074647345,0.022974579,0.014758556,0.08205575,-0.04650551 +3.4.24.82,In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.,384,1.0000001,-0.023654897,-0.083435744,-0.050122034,-0.0141050955,0.0053745825,-0.026915047,-0.054054286,0.10685692,0.0058695325,0.046579156,0.017495884,0.10998695,-0.033945553,0.017919673,-0.12001466,0.0031451469,-0.07400944,0.02192798,-0.07433641,-0.048021913,0.0038003244,0.0027530894,0.051178914,-0.03568156,-0.07700313,-0.05988686,0.02538691,0.0385879,-0.020776965,-0.050894964,-0.01745864,0.02338755,0.13121904,-0.034077115,0.027593307,-0.017366955,0.027961273,-0.010471108,0.02209009,-0.030421989,0.08451432,0.0061683035,0.010597226,-0.0060848105,0.072749615,-0.04434238,-0.039737046,-0.014699263,0.025880823,0.07972432,0.011905592,-0.0029867415,0.05261746,0.0019596384,-0.03782478,0.008036014,-0.07103732,-0.10426297,0.03630516,0.0528058,0.03994872,0.042240128,-0.05361574,-0.053956475,-0.04147382,-0.036499478,0.120761536,-0.10780842,-0.096750975,0.092217825,0.006025729,-0.050531957,-0.05090388,0.0805554,-0.020122137,0.09503643,-0.020376138,-0.088717505,-0.012575865,0.07032589,0.023009056,0.042959798,0.0811041,0.05057084,-0.06766571,0.00836079,0.032853544,-0.014889728,-0.037694484,-0.055771966,0.03162754,-0.048306514,0.007823578,0.042856835,-0.04704711,0.03284513,0.06857208,0.008505377,0.02475287,-0.016752241,-0.01108,-0.029129867,0.010788726,-0.049990892,-0.08545267,0.04147563,-0.044291664,0.04887313,0.087221704,0.053313773,0.0114150075,-0.016487228,-0.000112265465,-0.011303434,-0.07793657,0.06852879,-0.016068598,0.0279204,0.016143896,0.003927876,0.014580182,0.056885183,-0.015037758,0.012959003,-0.023100091,-0.052609485,-0.052273095,-6.670926e-34,-0.040742442,-0.058764577,0.03341776,0.0068195723,-0.02459621,-0.00629149,-0.071054436,-0.07342673,0.011077997,-0.040704392,-0.07058556,0.016885297,-0.01988292,-0.047318332,-0.081060715,0.15277202,-0.04263013,-0.04912992,0.014802332,-0.057099067,0.0013268879,0.11709955,0.034773245,-0.08533529,0.09875718,-0.010689348,0.034373794,-0.081824094,0.05558582,-0.005875562,-0.0017592858,0.006957451,-0.08336627,-0.014487494,-0.053667378,-0.044348996,-0.011783052,-0.038117796,-0.008081664,0.037110656,0.030162247,-0.0066736857,0.03619076,-0.03138215,0.05240736,-0.0568111,0.016390443,0.08852148,0.0039594113,0.02290845,0.015002526,0.02896333,0.03855468,0.08416481,-0.057173394,-0.007008453,-0.046482775,-0.04983016,0.056660306,0.01441051,0.10901911,-0.0055659297,0.03400363,-0.0020906294,0.020451697,-0.0032072149,-0.12665536,0.076391675,-0.04237653,0.10884751,0.041155335,-0.0260271,0.011637833,0.051962204,0.015209732,-0.054763872,0.046603836,0.20680223,-0.062710285,0.039038148,-0.017979547,0.03404686,-0.032153342,0.056928318,-0.04811742,-0.003346936,-0.0033861212,0.014613755,-0.040013324,0.031179858,0.021187654,-0.05349911,-0.1389075,0.050653752,-0.042705208,-1.0271879e-33,0.05783538,0.019976668,0.058452465,-0.013845894,-0.036248345,0.00070751744,0.042927198,0.06719344,-0.022871781,-0.041098546,0.005495478,0.04958288,0.007824011,-0.102284804,0.054575466,-0.0044589764,0.002014046,0.018967198,-0.115186274,-0.014745103,-0.063306436,0.1095759,0.010200974,0.009630593,0.037402783,-0.034747314,-0.0025200963,0.019372117,-0.032656092,0.014351529,0.050139233,0.018032124,-0.027804,-0.010201959,-0.039664064,0.004437476,-0.00761557,-0.052862138,-0.021814074,0.0011545024,-0.03130499,0.055588856,0.021890245,0.061419807,0.053085756,0.06947029,-0.03221815,-0.024485635,0.023208236,-0.081801124,0.017918468,0.00070918875,0.007597281,-0.018118463,0.12485214,0.007994814,0.050847493,-0.026742842,-0.013708023,0.0438945,0.036666926,0.06737947,0.031951934,-0.06931069,0.03521769,0.062190253,-0.062176198,0.007829936,0.012435278,0.093428,0.0077237026,0.013671201,0.0033369486,0.054000232,0.0069905743,0.089835376,-0.042746704,-0.03617419,-0.037230834,-0.060172237,-0.02165229,-0.063026294,0.010599063,0.025474504,-0.03148974,-0.023798209,-0.008621584,0.08480671,0.021480557,0.058031358,0.033568975,-0.03148878,-0.055877917,0.10552537,0.029040046,-2.3985447e-08,0.039380413,-0.025274044,-0.024150552,-0.044472203,-0.1261543,-0.015437441,-0.028698679,0.090167224,0.036971405,0.0031645915,-0.041649245,0.016474497,-0.0052083386,0.05143117,0.003127918,0.072630055,0.04246811,-0.035699002,-0.009734225,-0.044352625,-0.124824606,-0.03444305,-0.03794325,0.05099849,-0.055856694,-0.07381751,0.016598502,0.019755883,-0.08864618,-0.031457327,0.040373344,0.0007290053,-0.017398087,-0.0263125,0.0260652,0.038679108,0.0034952231,-0.09482651,0.014007065,-0.009075802,0.06216195,0.0038725145,-0.036315292,0.0022329208,-0.039310012,-0.05059156,0.008989265,0.036507633,-0.0338516,0.0044452185,0.03080274,-0.012016432,-0.06476801,-0.025500588,-0.100424014,-0.027330806,-0.022275487,-0.015215465,0.072061814,-0.009023146,-0.0051033217,-0.059980292,0.10919269,0.02373483 +3.4.24.83,"From the bacterium Bacilus anthracis that causes anthrax. One of three proteins that are collectively termed anthrax toxin. Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. In peptidase family M34.",384,0.99999994,-0.0040382277,-0.027312757,-0.05093821,-0.03961653,0.11438037,0.0014151837,0.0012883765,-0.02711327,0.07411426,0.009148544,0.0027573179,-0.034187052,0.060381852,0.075125754,-0.05772176,0.07333651,-0.14481501,0.07173176,0.012236775,-0.014951692,0.018156577,0.052043322,0.006912961,0.07018462,-0.07141136,-0.023424786,0.03846653,0.013931125,-0.0043705446,-0.053293593,-0.0038952825,-0.02515016,-0.042177487,-0.059457052,0.033765104,0.038171228,-0.046137705,0.0035798093,0.090563476,-0.0026424108,0.041935295,0.018509846,0.030344097,-0.038871225,0.0072386847,0.0953302,0.031987138,0.036504935,0.09474228,-0.028868897,-0.020656928,-0.005181427,-0.013786344,0.032010302,-0.043978553,-0.12123322,-0.1008698,0.019294372,0.033701956,0.040366277,-0.016982904,-0.03666708,0.05457844,0.0207407,-0.020517288,-0.036053494,-0.034863826,0.026300885,-0.020615457,0.08358584,-0.0019330452,0.004013244,0.009651007,0.033557527,0.037351873,0.088667035,-0.04566991,-0.012588478,0.014898511,-0.039950684,-0.030013395,0.030592665,0.100044996,0.11173483,0.01045091,-0.0051280954,0.022080878,0.02115724,-0.005094958,0.045886222,0.05940595,-0.025387008,0.09540395,0.05427142,-0.06617717,-0.079467304,0.046226002,0.03180452,-0.0068360153,-0.030691542,-0.055868585,-0.05165573,-0.051391672,0.045188922,0.017533345,-0.04263705,0.009328442,0.03785196,-0.0015640303,-0.030685466,-0.025446355,0.037549917,0.071173005,-0.048710227,0.027449828,0.039075386,0.013309796,-0.10195613,0.022282884,0.008792962,-0.04163482,-0.042861465,-0.061978858,0.066142164,-0.029754397,0.01307448,-0.087131076,5.0354185e-33,-0.040200803,0.03656993,0.0628746,0.0007675544,-0.0016118598,-0.0627493,-0.015897889,-0.101558134,-0.01859719,-0.052767076,-0.014047386,-0.03460755,0.03727664,0.05871291,-0.067723244,0.0025846683,0.024945106,-0.040755924,-0.06585592,0.0002505615,0.028230434,0.0050911442,-0.008617866,-0.050801884,0.038144723,0.05459066,0.0224507,0.031540725,-0.029411437,0.0022210244,-0.015109047,-0.00701666,-0.030909501,0.023507645,0.009971484,-0.02019567,0.01668377,-0.042672545,-0.0903066,0.05545753,-0.08618326,0.03748415,-0.10653929,-0.005769593,0.058525644,0.006861208,-0.053593688,0.10910227,-0.011512143,-0.010312036,0.022969611,0.027973775,0.078870885,-0.009994055,-0.004210312,-0.043415807,-0.07562981,-0.091594,-0.015183417,0.0342359,0.0497488,-0.039334808,-0.08134563,0.10260569,0.0099816555,0.0072359242,0.020408703,-0.043519072,-0.011368543,0.09383784,-0.08237412,0.038368035,0.05747599,0.021482471,-0.04811854,-0.022021243,-0.074438184,-0.0269964,-0.046269134,0.109605834,-0.032647848,-0.098122075,0.022781555,-0.023753874,-0.06657265,-0.020653177,0.042036857,-0.047369875,-0.019740017,0.07488872,0.020778079,-0.095741555,-0.02557267,0.15745021,-0.103325956,-5.4408472e-33,0.0499946,-0.013351054,0.086402066,-0.08932728,-0.10582469,0.109305516,0.039074317,0.0218152,0.06563539,0.017174082,-0.016359756,-0.00023662912,0.019154184,0.036621597,0.0053098025,-0.061796296,0.021415405,0.03779236,0.0378126,-0.002093716,-0.048515804,0.07154335,-0.06412097,-0.031732902,-0.006490424,0.047923047,-0.096476205,0.15919204,-0.021714184,-0.0336228,-0.030442297,0.07314186,0.048360217,-0.031186769,0.0013935607,0.0041038804,-0.029670464,-0.021870399,0.048644595,-0.060771037,0.019456234,0.032426625,-0.035391685,0.03515876,0.025985802,0.08285558,-0.031686578,0.048261575,0.03757313,-0.07807983,-0.021738213,-0.030684523,0.013646506,0.008541477,0.023718104,-0.014338863,-0.052223906,0.07545562,0.024004705,0.018291634,-0.03975369,-0.071626894,0.02875023,0.046915025,0.04045691,0.03299154,-0.056231085,-0.019130895,0.075971335,0.009857958,-0.0038361805,0.066600144,0.008765704,0.015136595,-0.0933311,0.06972143,-0.13048299,-0.06716939,-0.007926634,-0.0018140824,-0.042905446,-0.0007433712,0.0067370893,0.03213774,0.021329105,0.10566461,0.038539022,0.042848878,-0.004011193,-0.019916289,0.04443647,-0.06758876,0.00084443024,0.07213147,-0.03559605,-3.7141955e-08,0.06364821,-0.010031614,-0.016621703,-0.074304156,-0.042498395,0.036736228,0.0142464405,0.058794584,0.0060814014,-0.00899923,0.0254361,-0.01372439,0.027357515,0.0050140386,-0.009291573,0.014690201,-0.053004615,-0.030422993,0.021840747,-0.08043758,-0.04831434,-0.06399451,-0.04048433,0.061548732,0.03717232,-0.072106875,0.045987263,0.041122023,-0.013277059,-0.04360192,-0.013660599,-0.10762048,-0.005222018,-0.011361372,-0.039204303,0.09806509,-0.13754033,-0.059675556,0.102451414,0.008176981,0.07358508,-0.013989556,-0.027182829,-0.04631541,-0.013655818,0.016256656,-0.045194272,-0.070771694,-0.005370318,-0.07361009,0.059115555,0.016861992,-0.026331319,-0.03974358,-0.06572688,0.01324631,0.0077487673,-0.010957151,0.06141552,-0.049649794,0.043042015,-0.061245557,0.09785371,0.010596893 +3.4.24.84,"The enzyme hydrolyses proteins that terminate with a CaaX motif in which C is an S-isoprenylated cysteine residue, a is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.The enzyme, which is the Type example of peptidase family M48, is one of two enzymes that can catalyse this processing step for mating a-factor in yeast. Subsequently, the S-isoprenylated cysteine residue that forms the new C-terminus is methyl-esterified and forms a hydrophobic membrane-anchor. Differs from EC 3.4.26.1, intramembrane prenyl-peptidase Rce1, in its catalytic mechanism and substrate preference.",384,0.99999994,-0.00046981772,-0.078150734,-0.03058878,-0.06166385,0.11714082,0.10970974,-0.02970195,0.09723397,0.05979383,0.014482761,0.059931077,-0.0006366587,0.028218938,0.08467238,-0.022987828,-0.006181386,-0.07801461,-0.01929663,-0.028038189,-0.06755683,0.066238634,0.003682434,-0.064512216,0.02300887,-0.010860069,-0.045636304,0.033362478,-0.025420161,0.05266315,-0.02528033,-0.05412152,-0.04513643,0.049284313,-0.026257494,0.05212937,0.04500072,-0.028110638,-0.03901624,0.03391343,-0.0056418106,0.031661067,-0.0006388995,0.0024774424,-0.037903786,1.6660228e-05,0.03379605,0.024567448,0.036850397,0.014578264,-0.0054852697,0.006935545,-0.08661572,-0.03090533,-0.02529982,-0.0124239875,0.03696237,-0.050403543,-0.012009922,0.02282097,0.019375287,-0.0028593298,0.008294271,-0.008784112,-0.00020327843,0.04419466,-0.09924593,0.014448141,-0.027317263,0.056168444,0.0017528314,-0.06127477,-0.11001112,-0.08039684,0.07973856,0.0037629558,0.06103886,0.02396376,-0.07767299,-0.026850438,-0.03586767,-0.0013660544,0.001425302,0.06469035,0.045500737,0.075772114,-0.018365795,0.031086272,-0.021540439,0.0848027,0.021173049,0.03821495,-0.01573506,0.007342645,0.04142882,-0.061532058,-0.0077509615,0.054083522,0.040388484,0.009861942,-0.019396592,0.04722102,0.08351201,-0.03491926,-0.026059808,0.04376357,0.058719996,-0.031824674,0.109706216,-0.008950313,-0.020444404,-0.0093081575,-0.033505976,0.042748608,-0.047132306,0.021176076,0.018697271,0.02886241,0.014417047,0.0039861468,-0.03010398,0.0014812122,-0.0021673688,-0.023315111,0.010014262,-0.07751614,0.0028428726,-0.13382433,-3.9309606e-34,-0.02301841,-0.021092273,-0.03087135,0.023197504,-0.02183081,-0.0044307564,-0.0247177,0.056181245,-0.005588852,-0.014370924,-0.06479729,-0.04230017,-0.05494038,0.014111478,-0.08390173,-0.037826024,0.008029293,-0.015128874,-0.010293301,0.023947012,0.0008411584,0.035135403,-0.021482565,-0.087916575,0.14624818,-0.02322947,0.020481378,-0.013754625,0.05458861,-0.007545177,-0.096615985,-0.057934165,-0.10843968,-0.01213059,0.013481986,-0.048181877,0.06647309,-0.027439848,-0.017673342,0.042563464,-0.013953393,0.019777479,-0.017690284,-0.085240155,0.046409447,-0.03992207,-0.044679966,0.06977069,-0.0029901064,-0.007094384,0.05589063,-0.0018063684,0.07376116,0.02903319,-0.040424548,-0.01880309,-0.052611094,-0.014086305,-0.003057346,0.0424691,0.023845132,0.06941485,-0.03653497,0.06655604,0.030166391,0.034659915,-0.074872985,-0.06628125,0.026410414,0.10396962,-0.08010783,0.02571783,0.12563786,0.031088576,0.02823896,-0.15241137,-0.118507445,0.04084061,0.07572485,0.047584217,-0.005669509,0.015238335,0.016240042,-0.007342997,-0.054012764,-0.029267432,0.022815598,-0.052861486,-0.08769921,-0.015490993,0.06772421,-0.06314194,0.037371933,0.11622743,-0.052144226,-2.1105887e-33,0.09727418,-0.08695956,0.0786384,-0.100890845,-0.058638617,0.092190005,0.07584729,-0.04320316,-0.0019517889,-0.08032322,0.029310169,-0.0084751295,0.0060757073,-0.028145337,-0.0034349454,-0.009918759,-0.037436433,0.038081437,-0.056319084,-0.00047291364,-0.056331716,0.01875326,0.025877137,0.09284998,0.05806638,-0.004214111,0.003485138,0.06677557,0.009142981,0.046108127,-0.06541646,0.021678744,0.011233755,-0.041093715,-0.048622712,0.105525084,-0.073279105,0.016002947,-0.016047806,0.04415255,0.013326915,0.03657611,0.033474974,0.07031522,-0.02213906,0.09214071,-0.031585813,0.04526443,0.054113775,-0.080639444,0.003808671,-0.06818772,0.01302277,0.056884903,0.026566233,0.030220328,-0.0029321252,0.049762864,-0.0016689103,0.0062152697,0.0126389535,-0.042735003,-0.03466484,-0.027673135,0.07434952,0.017651249,-0.08745766,-0.024194576,0.06202677,-0.021076888,0.069731094,-0.017326342,0.0066039637,0.0013531166,-0.027069353,0.003799164,-0.034934342,-0.084992,-0.026615135,-0.065908425,-0.025780289,0.004289358,0.013397619,0.021514364,0.025827335,-0.036700785,0.019398343,0.04675628,0.011740815,0.045032755,0.031566925,-0.03004721,-0.017989008,0.09954625,0.08549276,-4.328736e-08,0.054464135,-0.07718613,-0.013971553,-0.10294723,-0.061766427,0.05590763,-0.0031793658,-0.042031046,0.029114412,-0.027566712,-0.045418553,0.032801226,-0.03441554,0.08129957,-1.8109175e-05,0.03213208,-0.073012196,0.056029476,0.006614371,0.013631688,-0.09257695,-0.023069318,-0.115709245,-0.011247092,-0.010087903,-0.052364163,0.046615824,0.13462955,-0.020688275,0.0034727713,-0.024111029,-0.0050460813,-0.034998585,0.052481618,0.046826277,0.07946623,-0.04827115,-0.047742315,-0.044809233,-0.025991675,0.08037418,-0.08382348,-0.0723393,-0.0022947597,0.040682968,-0.005722348,-0.0062473547,0.050794892,-0.01841407,0.04386096,0.050761815,0.005326163,-0.025866915,-0.09733838,-0.04852018,-0.0074221385,-0.029864011,-0.073448956,0.019788459,-0.08196011,0.05497618,-0.017589932,0.18859705,-0.04721314 +3.4.24.85,"Type example of peptidase family M50. The transcription factors SREBP-1 and -2 are synthesized as precursor proteins that are attached to the membranes of the endoplasmic reticulum and two cleavages are needed to release the active factor so that it can move to the nucleus. This enzyme cleaves the second of these, and is thus the ""site 2 protease"", S2P.",384,0.99999994,-0.04304903,-0.09249579,-0.09734556,-0.05295027,0.109778635,0.05167176,-0.03920693,0.093799,0.0019005912,0.038889553,0.07315884,0.011823447,0.029313806,0.065620564,0.024691578,0.04543306,-0.092931464,-0.023620127,0.0623619,-0.09331936,0.03447628,0.01580532,0.028753756,0.019771356,-0.00072888564,0.0021535037,0.030924862,0.011893419,0.053145736,-0.056459766,0.0075149057,-0.039872732,0.009512773,-0.07822072,0.10523275,0.00945726,-0.023819957,0.0077635385,-0.028070483,-0.020617329,0.081296094,0.014281338,-0.004886068,-0.07771795,0.021307772,0.00916063,0.022502901,0.08431845,0.011912823,-0.038923413,0.010845023,-0.084255606,-0.04956712,0.013970623,0.012693597,0.07694897,-0.03345595,-0.0050686784,0.06403337,-0.014051729,0.0072177923,0.013272601,-0.023799375,-0.066113755,0.08375395,-0.038331598,-0.022478972,-0.027959751,-0.016145531,0.03279772,-0.043487687,-0.091891654,-0.07514504,0.11531027,0.0012900846,0.037604965,-0.0058506047,-0.014330403,-0.038761847,-0.026219107,-0.060465608,-0.032092866,0.116379514,0.034887094,-0.027256975,0.034663547,0.05934093,0.006676658,0.017555097,-0.04461023,0.027639797,-0.09520411,0.044719912,-0.005786072,-0.0442576,0.06531837,-0.04289289,0.0033768783,0.017025093,-0.047937587,-0.0036612304,-0.008610952,0.02422047,-0.08225698,-0.013224386,0.052216068,-0.038927395,0.05912965,0.045922488,0.019543234,0.007470778,-0.018709848,0.041181102,-0.025271978,0.055156313,0.019115543,0.007854438,0.016799338,0.04576908,-0.04005614,0.024298897,-0.011281151,-0.00411222,0.042908352,-0.06039177,0.042493474,-0.11885676,5.664813e-34,0.030755773,-0.03610882,-0.024875453,0.08840086,-0.02328004,-0.013893077,-0.04100104,0.01114431,0.025319027,-0.079263665,-0.057778887,-0.11406109,0.00467576,-0.014343086,-0.11513873,-0.032652933,-0.029733881,-0.017111184,0.031330917,0.05291155,-0.029912489,0.14022426,0.03836488,-0.056353293,0.13035987,0.029122585,0.037134282,-0.005814814,0.043917432,-0.016145073,-0.043380145,-0.038220342,-0.109163105,0.02033997,0.0076181954,-0.043876145,0.05552195,-0.07020536,-0.05093593,0.026601864,-0.015003318,0.040350847,-0.071287766,-0.054748632,0.09437951,-0.08066512,0.028087176,0.08385531,-0.01544047,0.0013603618,-0.017024955,0.028065035,0.050426416,0.0089999465,-0.05732159,0.006180191,0.0063916775,0.01814651,0.095907874,0.054612093,0.011270713,0.040896267,-0.026571216,0.08464927,0.0516686,0.05215228,-0.09201418,-0.023682259,0.050138596,0.12514478,-0.01010335,0.040498413,0.109984495,0.038939692,0.027926499,-0.11512947,-0.034555018,0.0325313,-0.013180066,0.06265083,-0.03553998,-0.010840793,-0.05708171,0.017258031,-0.023815203,-0.10097191,-0.035612717,-0.09982671,-0.068575904,0.009942016,0.01700203,-0.047049068,0.010882884,0.15687212,-0.02865151,-1.601855e-33,0.0017580105,-0.025664905,0.069668986,-0.036436234,-0.05299238,0.052475147,0.07622082,-0.043212365,0.007475432,0.0071741147,0.02232947,0.0024044276,0.0013642831,-0.070200145,-0.0041704723,-0.033787075,-0.023034453,0.057081833,-0.020504536,-0.017662996,-0.047462415,0.07619931,0.0022160844,0.056896877,0.043059334,0.05123983,-0.03705337,0.07806863,-0.014384927,-0.019875478,-0.040284913,0.08828938,-0.0011438209,-0.03591754,-0.0926289,0.030595368,-0.06605984,0.02755012,-0.0054551805,-0.04253949,0.008617115,0.112120755,0.015087593,0.047773357,-0.011894761,0.02213685,-0.0140710035,0.0336567,0.031722903,-0.11185261,-0.06449718,-0.0910687,-0.022040725,0.008178397,0.020002125,-0.05727753,0.02103372,0.094253905,0.009256265,0.023363762,-0.009124584,-0.029396739,0.040403347,0.052391656,0.094179764,0.028431391,-0.04418701,-0.01775164,0.018396417,0.08784667,0.030610109,-0.015951583,0.010389395,0.02638211,-0.015056734,0.038697295,-0.04552535,-0.035218976,0.008844088,-0.08945917,-0.04553373,-0.03958396,-0.042973816,-0.021801377,0.024323564,-0.034351926,-0.03427883,0.091201104,0.058070652,0.04243796,0.013133443,-0.005747661,0.0014624641,0.12572499,0.049152557,-3.982457e-08,0.04020508,-0.04048682,0.045523584,-0.03516432,-0.03460743,-0.0455353,-0.049732257,0.0065362933,0.05368483,-0.00086367386,-0.05413269,0.0073795337,0.0034046168,0.0143984305,0.050517768,0.08131298,0.0077185757,0.019425236,-0.026220443,-0.036388077,-0.04023561,-0.06656398,-0.050908055,0.067190245,-0.03425966,-0.09261448,0.023885645,0.084081605,-0.019043023,-0.06371041,-0.0069557796,-0.016996676,-0.02896306,-0.0014664,0.046026543,0.05717763,-0.0065505225,-0.014001352,-0.019337345,0.017570473,0.052620146,-0.070217185,-0.01946744,-0.033782925,0.009253651,0.011048097,-0.019446803,-0.026494704,-0.071128376,-0.019269766,0.02301297,-0.017045517,-0.03989124,-0.10418421,-0.09968812,0.048502788,-0.014761882,-0.014928025,0.045008972,-0.08278639,0.05152963,0.0390116,0.13941205,-0.036217052 +3.4.24.86,"In peptidase family M12. In vivo, the cleavage of tumour necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation.",384,1.0,-0.013559753,-0.063942544,-0.07153933,-0.049625836,0.039482195,0.02389724,-0.070101336,0.022744771,0.0049468474,0.092382185,0.027868293,-0.034729663,0.032577924,0.061475124,0.006151842,-0.004694048,-0.03614029,-0.03138558,-0.045896634,-0.08207019,-0.025208721,0.04570322,-0.016996179,-0.045975402,-0.030649664,0.012466108,-0.0018951762,-0.0426325,0.07244354,0.033546932,0.014815529,-0.013941279,0.042462565,-0.0287748,0.065101236,-0.07006066,-0.08166365,-0.0055766874,-0.044238966,0.0024628988,0.033912487,0.006390604,0.0022674443,-0.010160217,0.08745656,-0.07346867,0.0020791611,0.08533104,0.11228209,0.038232747,-0.030564578,-0.012561564,-0.0019201604,0.067408875,0.05477016,0.01438443,-0.09501379,-0.04710977,-0.03609378,-0.010155135,0.0021080968,-0.01782561,-0.007151855,0.024793131,-0.028160777,-0.095883645,0.011341852,-0.019241411,-0.08772173,0.097002946,-0.0016108198,-0.040567026,-0.06338627,0.03617855,0.0032730352,0.087104954,0.013482413,-0.09277398,-0.06414077,0.01536493,0.087763034,0.057373524,0.16268523,0.061284162,0.036250096,-0.011889609,0.09502398,-0.034605365,-0.036466304,0.023389146,0.059897427,-0.013520641,0.05073675,0.06829463,-0.022280218,0.028581796,-0.04295567,0.022000998,-0.060919117,0.019247847,-0.087836765,0.0050249784,-0.1128872,-0.04649079,-0.072640665,0.06388683,-0.07838402,0.029051919,0.05284522,0.06629946,0.077506416,-0.038681462,0.014063462,-0.081696205,0.035371542,0.041035898,0.043690797,-0.055862017,0.015146418,-0.017749833,0.033068914,-0.048781633,-0.022232084,0.051431373,-0.034777727,0.07171661,-0.026479153,-6.22805e-34,0.074620746,-0.009600123,0.01940922,0.018640785,0.038037404,0.0120447995,-0.01810435,-0.061463602,0.019517625,-0.076968595,-0.04187071,-0.05597231,-0.0014210143,-0.030273652,-0.08506393,0.017983302,-0.027050693,-0.010185655,0.007166955,0.018763484,-0.0031585214,0.071362965,0.00848671,-0.1304148,0.033692393,0.03630537,0.03181566,0.038682662,0.04642174,0.0027627384,-0.12408413,-0.01665704,-0.068655275,-0.040637434,-0.10062362,-0.037867486,0.03179792,-0.07951664,0.004314025,0.046249643,0.014791267,0.015468534,-0.040370315,-0.060517214,0.070573986,-0.0765312,0.0017439205,0.054007452,0.001962002,0.048845604,-0.0017920138,-0.0059693423,0.061137095,0.018218726,-0.03348216,-0.00870121,0.030143943,-0.041424025,0.103260875,-0.025530638,-0.033511724,-0.101950794,-0.023044094,0.100750245,-0.04101438,-0.016203497,-0.041523874,-0.032661244,0.02254319,0.05747739,-0.029155754,0.029390637,0.037419047,-0.0029126818,0.058549885,-0.09614991,0.020611735,0.052816503,-0.07774351,0.09487708,0.034113094,0.017048107,0.0150888935,0.041570764,-0.006947192,-0.05148424,0.0011185644,-0.0171949,-0.021009779,-0.04978577,0.014545233,-0.042743582,-0.068889275,0.117653675,-0.020662507,-9.2911615e-34,0.09889085,-0.07752942,0.042253606,-0.039876558,-0.026229732,0.034489963,0.011806895,0.035807725,0.07670016,-0.041877385,0.053332467,-0.011144629,-0.04200916,-0.0013101074,0.04865556,-0.058955777,0.015408831,0.12846708,-0.08860594,0.010581455,-0.05952293,-0.01718983,-0.010419008,0.06523783,0.07538698,0.01948338,0.022885026,0.038669113,-0.08156292,-0.0065249195,0.012124875,0.009131022,-0.042676795,-0.0011083237,-0.04355777,0.03881841,0.025624966,-0.035422485,-0.009880748,0.002854296,0.0130786095,0.10961744,0.034453552,0.05474225,-0.04966895,0.035227347,0.0010899614,0.04799563,0.050381307,-0.124765776,0.019530011,-0.06195711,0.06811066,0.07581504,0.08441711,-3.486397e-05,0.01711421,0.07097707,0.057794157,0.049058694,0.041875895,-0.028516987,-0.01691327,-0.016102599,0.036223777,0.043857876,-0.050013088,-0.023075882,0.013316116,0.049566213,-0.066351965,0.007473353,-0.04230597,0.0046437783,-0.0111868605,0.06994638,-0.04107259,-0.039371617,-0.012647379,0.03333073,-0.019422652,-0.062087227,-0.04036608,-0.012694281,-0.0054822476,-0.018447898,0.040318307,0.07154313,0.025989821,0.03257402,-0.023584986,-0.009478898,0.009215248,0.028378382,-0.020490125,-2.8485932e-08,0.076770574,-0.08491569,-0.030805482,-0.10201053,-0.08597243,-0.024708925,-0.03843745,-0.027103515,0.07327721,-0.008261406,0.08358752,0.0083522815,0.006991142,0.041743785,0.0214941,0.08827288,0.013094854,-0.034612466,-0.0074250842,0.016744448,-0.06552426,-0.006150544,0.036813002,-0.015190252,-0.0008374893,-0.06896589,0.027227536,0.032967657,-0.018081097,-0.040266458,-0.056249823,-0.06533081,0.010310522,0.041331798,-0.055261016,0.06460796,0.0830089,-0.08153711,0.034288652,-0.04266677,0.062020686,-0.03273581,-0.043744724,-0.08577224,-0.060169447,0.007966717,-0.0071379985,0.013664914,-0.07137939,-0.091758326,-0.03298763,0.016262924,-0.030233456,-0.045333464,-0.060848724,-0.014046541,-0.06298092,0.016166342,0.0818791,-0.106223255,0.04441456,0.02043056,0.14529105,0.03976031 +3.4.25.1,"A 20-S protein composed of 28 subunits arranged in four rings of seven. The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity. In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. The molecule is barrel-shaped, and the active sites are on the inner surfaces. Terminal apertures restrict access of substrates to the active sites. There is evidence that catalytic subunits are replaced by others under some conditions so as to alter the specificity of proteolysis, perhaps optimizing it for the formation of antigenic peptides. A complex of the 20-S proteasome endopeptidase complex with a 19-S regulatory unit is the 26-S proteasome that degrades ubiquitin-protein conjugates. Type example of peptidase family T1.",384,0.99999994,-0.029568987,-0.09317954,-0.081262335,-0.021580739,0.0972955,0.056174494,0.018930713,0.11217489,0.07253658,0.023759386,0.02618595,0.033294667,-0.0056291423,0.11023478,-0.0038048753,-0.037485443,-0.12076993,-0.017999008,-0.0053459457,-0.08531092,0.056555405,0.029033573,-0.04738273,0.03183991,-0.059121028,-0.0253893,0.020808587,-0.058992572,-0.00260096,-0.06900057,0.007935282,-0.0636088,0.008698257,-0.021425849,0.086150065,-0.01740147,-0.10077613,0.02115161,0.032796115,-0.085929856,0.0609827,-0.032078426,-0.016139885,-0.079183504,0.031680465,0.037824597,-0.011825456,0.07915113,0.075063705,0.031408835,0.026626363,-0.0706902,-0.0006564859,0.043175235,0.011778225,0.046164446,-0.020667128,-0.01677674,0.055078123,-0.016740046,0.04440326,-0.04848968,-0.023645153,-0.04645554,-0.012596038,-0.03273367,-0.010801023,-0.00038552098,-0.008853215,0.03001537,0.019164965,-0.03775112,-0.10125295,0.091240466,-0.020190822,0.06506628,0.0074078464,-0.055739846,-0.06650243,-0.03328309,0.030947048,0.036454,0.1466933,0.038932286,0.015525724,0.020358274,0.023825139,0.015167421,0.06559487,-0.01243624,0.011238921,-0.06115936,0.005706784,-0.013781527,-0.022246314,-0.019658469,-0.008256325,-0.0065388074,0.01432862,0.009904298,0.036894258,-0.0008174451,0.04117043,-0.10139177,0.0032273547,0.110672355,0.0339431,0.08812769,0.057790823,0.016982742,0.0009536679,-0.02774663,0.055135004,-0.04469983,0.04849249,0.0063224714,-0.030705465,-0.004038364,0.028513722,-0.007023342,0.046188556,0.014760449,0.052006632,0.04300895,-0.030745829,0.0435382,-0.12176696,2.8653878e-33,0.0041573728,0.006182837,-0.026410466,0.05382323,-0.0043290653,0.011858613,0.01374775,-0.0077119153,0.012994043,-0.022053134,-0.0562366,-0.06497912,-0.0104769515,-0.013647441,0.00548825,-0.0463136,-0.013821374,0.018875005,-0.02493478,-0.009749677,-0.077120386,0.069367826,-0.03234548,-0.056939617,0.102228284,0.01270813,-0.0020852229,0.022437852,-0.009012883,0.013263895,-0.04519098,0.01008026,-0.12244501,0.093895674,0.027148595,-0.028203845,0.02487271,-0.024167629,-0.0028762706,-0.013632602,0.04822072,0.023286624,-0.091730595,-0.01926565,0.1119921,-0.08975293,0.06961114,0.08428753,-0.08205817,0.017055206,0.030559307,0.004817865,0.055885207,-0.056042224,-0.066071875,0.019352952,-0.028363463,-0.008895582,0.09999489,0.07579788,0.027499205,-0.008791128,-0.050188918,-0.00088961574,0.0094113555,0.07561091,-0.0768784,-0.03451734,0.016585613,0.09935957,-0.038978495,0.05747668,0.13950168,0.015437532,0.0090991305,-0.08552045,-0.037824016,0.036913455,-0.006642034,0.056991603,-0.0044199666,0.0843836,-0.06673681,0.005830105,-0.022015829,-0.040310025,0.050854925,-0.086066775,-0.08592646,-0.008855114,0.037668575,-0.11680311,-0.034930993,0.14167581,-0.0818779,-3.2651354e-33,0.037030425,-0.10677399,0.040977053,-0.070579246,-0.023009067,0.035409767,0.04407217,-0.0022359623,-0.037119802,-0.082964644,0.07755337,-0.041270904,-0.032070495,-0.051691305,0.013570563,-0.01984286,-0.04970489,0.08701394,0.007843059,-0.03714524,-0.022407807,0.021654144,0.011517121,0.044302326,0.018059136,0.062355313,-0.019780846,0.024595289,0.072296284,0.06335417,-0.03095699,0.027651237,0.03638545,0.024881637,-0.090722375,0.070715114,-0.017594678,-0.022354277,0.07946847,-0.052092306,0.012505645,0.0037450006,0.042422753,0.040426243,-0.004404048,0.04786741,-0.00549406,-0.010823297,-0.0460855,-0.11299549,0.04175239,-0.082444906,-0.023441544,0.046521086,-0.012899782,-0.012087505,0.02686703,0.05123836,-0.008062231,-0.008826556,-0.0015139588,-0.023608191,0.028430747,0.06284101,0.03287956,0.0018262123,-0.07476725,0.028263418,0.04801118,0.045102846,-0.024605611,-0.05155286,0.03518629,-0.04264436,0.05011179,0.0051514087,-0.028069384,-0.04360009,-0.004886814,-0.036752943,-0.09367174,-0.038701184,-0.069950774,-0.013604683,0.06137171,-0.05446328,0.033368602,0.08988441,-0.0048113735,0.09971512,-0.03097618,0.004326999,0.049514834,0.109416984,0.09654027,-4.6995638e-08,0.104923025,-0.038821492,-0.00069544226,-0.049544435,-0.03985507,-0.021130346,-0.045165535,-0.00036170572,-0.004383719,-0.028858235,-0.008727962,0.0060176784,-0.03076627,0.026047708,0.017934948,0.036466736,-0.06045745,0.011792336,-0.015175712,-0.031264693,-0.024161218,0.046772763,-0.072947696,-0.037197094,-0.046861097,-0.061105844,0.03741312,0.026660232,-0.094438985,-0.043821953,-0.018313603,0.013084961,-0.13389732,-0.015270361,0.066514954,0.049713846,-0.022700746,-0.0648517,-0.019332293,0.0072049336,0.021995949,-0.06031353,-0.082774065,0.0017956588,0.023636222,-0.02277946,0.006295258,0.04294091,-0.0753739,-0.033263687,-0.02934237,0.0106492415,-0.053831734,-0.06631984,-0.06484329,0.056304004,-0.0030009784,-0.071316846,0.032415565,-0.01325753,0.038766082,0.043282136,0.119892456,-0.034572992 +4.1.1.1,A thiamine-diphosphate protein. Also catalyses acyloin formation.,384,1.0,-0.0873112,-0.035213787,-0.08331258,0.031508673,-0.008766458,0.013322262,0.032273456,0.040177606,0.013900206,0.028145973,0.07043084,-0.04857197,-0.0027952457,0.02979805,-0.01693379,0.055979032,-0.03562212,-0.046481498,0.00866165,-0.10704172,0.0096479505,0.06667267,-0.08598324,-0.040456343,0.013854706,0.008476398,0.05933099,-0.056120146,-0.020274056,-0.07846793,-0.078086935,-0.02154681,0.0072765546,-0.01639599,0.03189669,0.060879473,-0.069409825,0.007842246,0.06662132,-0.014391797,0.052445553,-0.029722186,0.01031458,-0.023071133,-0.061938193,-0.012386492,0.05983552,0.10887296,0.044260766,0.03950954,-0.036047857,0.0033883932,0.004097963,-0.003616343,-0.0061763953,-0.01113587,-0.04460908,0.009711911,-0.030739745,0.01217784,0.0040515214,-0.016181467,-0.03608949,-0.03379365,0.07382137,-0.10294655,0.006403197,0.0062562283,0.059775382,-0.016658226,-0.013164419,-0.024477309,0.03261138,-0.012007456,0.007587313,0.03422668,0.0017630381,-0.059400562,0.049239498,-0.008007253,0.024112087,0.013148981,0.066131465,0.07640937,0.08024041,-0.059048105,0.05629505,0.04963936,-0.02407115,-0.038953386,0.029267853,-0.0017228645,-0.02139184,-0.0004913183,-0.067463785,0.043526433,0.0634197,-0.03414436,-0.06865592,-0.01015576,0.05306815,0.06570562,-0.003202147,-0.07956304,-0.021067383,0.011996271,0.0027683356,0.029552253,0.009880516,0.028518228,-0.009637803,-0.0052196686,0.03546964,-0.028116688,-0.0454627,0.07220129,-0.049051527,-0.0037624615,-0.06662078,-0.03306164,-0.031877015,0.050111312,-0.01580138,0.078899495,-0.06042214,-0.033199,-0.09175235,5.791272e-34,0.056878064,0.098449655,-0.033267755,-0.053893033,0.0038073363,-0.032894865,-0.07767537,0.105896674,-0.0045138984,-0.01451773,-0.0040429886,-0.123930275,0.10195103,0.0033093786,-0.052515894,-0.10634842,-0.03985777,0.02495752,0.1030556,-0.012775778,-0.07389329,0.07032994,-0.043336917,0.01957366,-0.013856482,0.010670601,0.006205379,0.06642556,-0.01221491,0.008894394,0.031427886,-0.058429178,-0.09888266,-0.030350026,0.04591394,-0.04444583,-0.034067456,-0.049435932,-0.08650575,0.010122238,0.046057627,-0.008320575,-0.039348226,-0.048731536,-0.0013610234,-0.09508324,-0.08040177,0.07111192,-0.015226624,0.039239075,0.0031295223,-0.011819674,0.12774916,-0.016065529,-0.08998012,-0.03345567,-0.04933729,-0.04328557,0.060574345,-0.029857783,0.02803134,-0.014695034,-0.10295092,0.013432353,-0.12425138,0.028790843,-0.08568352,-0.018938722,0.03270453,0.08732685,0.037148517,0.008911099,0.07603488,0.003705356,0.009708202,-0.00879195,-0.042024635,0.047329653,0.01382253,0.056840282,0.05236315,-0.038022194,0.046639685,-0.028149834,-0.044833887,-0.05881361,0.024068661,-0.016651822,0.03415204,-0.04095541,0.017037403,-0.02087112,-0.04722783,-0.010508094,0.052739754,-1.8487997e-33,0.11007937,-0.09013273,0.013770111,-0.10258711,-0.01847328,-0.03553592,0.07016846,0.004656794,-0.009318224,-0.059861973,0.06658159,-0.006512247,0.017025314,-0.07742723,0.025622072,0.086711995,-0.016229957,0.07144396,0.09759261,0.006582635,-0.07475043,0.015428807,0.022464612,0.041298408,0.011730859,0.035136554,0.0011905073,-0.022821095,0.021321781,0.12830426,-0.002884427,0.022375215,-0.05680792,-0.018653288,-0.09253554,0.04001558,-0.024766479,-0.06675639,0.0047065658,0.07095344,0.025063518,0.04639226,0.06400218,0.077156655,0.10654382,0.062484294,0.0010192234,0.0056396867,-0.06574877,-0.11994415,0.08307561,0.031297266,0.02616921,-0.056722462,0.05286246,0.0708972,0.004610464,-0.018889735,0.047588434,-0.061630014,-0.0182098,-0.0915271,0.017944911,0.008072744,-0.006302959,0.050355785,-0.039213054,0.0720055,0.05864413,0.022932367,0.0557723,0.09274246,0.05019477,-0.02313118,-0.024780994,0.037033144,0.015060203,0.024669286,-0.0372393,-0.0030762907,-0.007918791,-0.006019049,-0.022128625,-0.035688475,-0.058843788,0.014976792,-0.009610208,0.057436474,-0.054762263,0.06222686,-0.082585245,-0.0050536306,-0.0008602493,0.116001554,0.122027166,-2.3290976e-08,0.05170448,-0.052295025,0.05437488,-0.022641199,-0.00394617,0.097992316,0.043291587,0.0031673352,0.09431018,-0.026000643,-0.049341347,0.046129532,0.009446124,0.06259827,0.021445438,0.01204056,-0.029104412,3.145254e-05,-0.03625867,-0.0028203689,-0.064527035,0.03975792,-0.02157235,0.019402267,-0.008779146,0.026692443,0.0279255,-0.046357483,-0.07038075,-0.08169538,0.0026896526,0.03308053,-0.04059345,-0.0771639,0.020313006,0.056006506,0.07355117,-0.08340412,-0.053941343,-0.03106766,-0.009883283,0.030151423,-0.08963665,0.023389312,0.051050406,-0.023081886,0.036573075,0.08392359,-0.057753626,-0.076000795,-0.0061320313,0.015822371,-0.019892462,-0.066052146,-0.0061991396,-0.009391215,-0.074008994,-0.02711588,-0.023853956,-0.040488344,0.0030053996,0.04587522,0.1557244,-0.057972066 +4.1.1.2,"The enzyme from Bacillus subtilis contains manganese and requires O2 for activity, even though there is no net redox change.",384,0.99999994,-0.05349549,-0.08055455,-0.010295062,0.03534754,0.07257757,-0.036049504,-0.03921698,0.043900512,-0.023204893,-0.05765995,0.053317253,-0.05630321,0.07917244,0.046409532,-0.003815516,0.062345594,-0.026824346,-0.0003888375,-0.015044245,0.025969489,0.12069495,0.05865278,-0.005737791,-0.08159784,0.04178402,-0.016440602,0.054096982,-0.09192248,-0.033311095,-0.051152423,-0.054077163,0.03265235,0.110991135,-0.1024248,0.071751006,0.04974673,0.023193102,-0.010208744,0.044558495,0.009454525,-0.02879064,0.055698615,0.062382396,-0.022279305,-0.0049604103,0.019003622,0.088281,-0.11234816,0.006572267,0.014259443,-0.0632506,-0.020958733,-0.051882274,0.03135243,0.011761755,-0.021634417,-0.05403099,-0.013902883,-0.026229922,-0.007954998,0.024758792,-0.050618656,0.05849301,-0.03038758,0.032427873,-0.014780045,0.0055156494,-0.043886434,-0.026308374,-0.061409477,-0.019444427,0.02082925,-0.00021435715,0.03354882,-0.007959266,0.017731803,0.06587936,-0.00084317283,0.06648842,-0.013892505,-0.037269905,0.016946588,0.035771213,0.06862201,0.070158795,0.09105511,0.029366227,-0.03849768,-0.025226658,0.05664241,-0.015637606,0.034720864,-0.01618964,-0.047454152,-0.010806705,-0.030961415,-0.04057176,0.08564451,0.001075621,-0.019692149,-0.03178382,0.07752051,-0.040186554,-0.052838694,-0.016054308,-0.061393857,0.0661403,0.0600712,0.075927235,0.04601192,0.11483686,0.021127457,0.07060169,-0.0687716,-0.006038107,0.04443185,0.0790831,-0.04535556,-0.13877995,0.007984218,0.012042735,-0.02392294,-0.01554666,-0.042940423,-0.053879667,-0.011627443,-0.026078168,2.677983e-33,0.047195815,-0.0043275333,0.036826804,-0.01953527,0.0073510576,-0.03925532,-0.08494279,-0.04901578,0.055826206,-0.07505114,-0.115556434,-0.036473956,-0.0034244899,0.043536544,0.03120582,0.016959444,0.057403065,-0.06593791,0.092398055,-0.021455897,0.06277115,-0.023350047,-0.02758111,-0.0068561565,0.02408182,0.022825563,0.09616181,-0.07874685,0.0104339225,-0.03386705,0.07190794,-0.10730173,-0.08204911,0.030912254,0.042208433,-0.015912637,-0.04670515,0.029977193,-0.0647321,-0.004599009,-0.04594175,0.08951895,-0.09112174,0.015078035,0.066423416,-0.117118336,-0.07471369,0.10087996,0.002660397,0.06518374,-0.011655034,0.07004711,0.09300158,-0.018414184,0.011353487,-0.012408507,0.063442394,0.07003876,0.006998763,0.06686819,0.010540127,0.03734561,-0.0008647663,0.12293954,0.020310346,0.105382666,-0.04752739,-0.047964647,-0.0027791623,0.010414137,-0.04584108,-0.01737827,0.025807671,0.0070822416,-0.09431845,-0.04577665,-0.04142958,-0.055975646,0.04777175,-0.016383795,0.017917516,-0.033896986,0.025770737,-0.03377552,-0.085179776,0.020614969,0.015683373,-0.020751417,0.006221238,0.07277453,0.14543852,-0.0774437,-0.08124871,-0.01244553,0.023380322,-1.8636207e-33,0.06267621,-0.051860623,0.0112058725,-0.14186105,-0.06758575,-0.0041977507,0.008583124,-0.011719547,0.034827128,-0.017562475,0.045936875,0.0130544845,-0.0328484,0.05035967,0.0005128323,0.06292856,0.0039240452,0.11539159,0.046284586,0.015733225,-0.027836718,0.14799012,0.018195014,0.007793215,0.04872937,0.062041897,-0.022638202,0.11086264,0.016927443,-0.0469643,-0.04150809,0.022889815,-0.0140831275,-0.036964465,-0.028409062,0.058890548,-0.012560551,-0.034287207,-0.00092599564,0.027155641,0.0042495015,0.005755687,-0.034647763,0.081089504,-0.008231824,0.029226892,-0.08984306,-0.013416624,-0.0030854787,-0.07397736,0.02373743,-0.024919193,-0.0141152935,-0.07265733,0.05620083,0.0055449842,-0.05445241,0.036059733,-0.020360392,-0.08009199,0.0072866664,-0.030412214,0.00519004,0.013091753,-0.020959128,0.12828304,0.04991729,0.027448101,-0.010265419,-0.049940392,0.028313136,0.024001189,0.050708815,0.00088682945,-0.014019164,-0.033790797,-0.05121567,0.030870179,-0.008532289,-0.009748934,-0.03602559,0.003676019,-0.027095687,-0.051253226,0.021237766,0.000776012,-0.055666074,0.03477321,0.014914966,-0.013922917,-0.04934161,-0.04019245,0.0032268092,0.034437906,0.056597736,-2.5725676e-08,0.021667363,-0.06377614,0.0532691,-0.015492012,-0.009591023,0.006090727,0.008265339,-0.034653936,0.025633253,-0.018324858,-0.025804637,0.10344849,-0.00037347796,-0.09299377,0.0418158,0.0024805104,0.008473357,-0.014804396,-0.020802932,-0.022546608,-0.035505466,0.0145756425,-0.07352199,0.11870102,-0.015157615,-0.03506851,0.012127443,-0.01423906,-0.00738146,-0.0780364,0.04424296,0.0207952,0.02721615,-0.021612963,-0.121738896,-0.028040502,0.012056549,0.033694472,-0.032436553,0.03382438,-0.040021192,-0.016385384,-0.06687772,0.00073401345,-0.035293557,0.020877216,-0.07890915,-0.0027170286,0.017674332,-0.08588113,0.05098766,-0.057045102,-0.009375964,-0.021077562,-0.11228613,0.06689709,0.060174912,-0.0003029036,-0.0304998,0.05204631,-0.026011286,-0.018882899,0.13584077,-0.07239721 +4.1.1.3,The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+.,384,1.0,-0.05864947,-0.013088345,-0.052672286,-0.040221322,0.018679628,0.029306095,-0.021921609,-0.024642745,0.032731716,0.007813233,-0.011898542,-0.09649564,-0.036128517,-0.0088838115,-0.045606617,0.05980433,-0.09840989,0.0058593447,-0.05905258,-0.031597294,0.121239565,0.043506827,-0.036348023,-0.010418639,0.034023356,0.033296205,0.010848456,-0.024425393,0.023405708,-0.074003875,0.025992937,0.028848972,0.0027583952,-0.019982649,0.07325526,0.031595968,-0.05436835,-0.03651825,0.025808876,-0.014439104,-0.00925273,0.008839541,-0.013390113,-0.012811941,-0.08860473,-0.005004523,0.027581444,-0.029633544,0.06279101,0.024316186,-0.05994156,-0.09132685,-0.00846901,-0.000842533,0.057538312,0.041672014,-0.090801075,-0.07337794,-0.0059486795,-0.00964356,0.056127753,0.0037519396,-0.040614035,0.0153343985,0.008013143,-0.026049595,-0.062778026,-0.015441685,0.061014075,-0.09326155,-0.010594646,-0.119088836,0.0012037439,0.08682998,-0.05952986,0.02212158,0.019781962,0.016120592,0.07035186,-0.0041551357,0.0101042045,-0.03468752,0.035331275,0.057495303,0.014373141,-0.014485711,-0.012165459,0.025407868,-0.032313287,-0.0026986673,0.07299456,0.004205138,0.053663615,-0.026442235,0.013053989,0.007843861,0.00025945224,0.029626952,0.020089222,0.021957992,-0.033862207,0.06681168,0.06705984,-0.062022086,-0.08086175,-0.10055175,0.06004657,0.05761976,0.0322213,0.010882782,-0.037570547,0.005304464,0.024193833,0.023060236,0.035087638,0.055843867,0.09207346,-0.12565832,-0.028932506,-0.03878407,0.024350096,-0.038068313,-0.012409498,0.04136978,-0.02923024,0.07208292,-0.09305141,3.7925525e-33,0.09280547,-0.010702882,0.0342166,-0.01894157,0.004480337,-0.029240107,-0.07250677,-0.07122909,0.027930696,-0.09259175,-0.12865555,-0.03299652,0.011382958,0.04321331,0.026862903,-0.04701377,-0.10237519,-0.023270674,0.0666304,0.04144551,0.02845327,0.055208713,-0.05263607,0.04242571,-0.0069431583,0.009616399,0.022660313,-0.04071056,0.04744611,0.019234348,0.054135516,-0.0784333,-0.09520141,0.04189692,-0.018068502,0.048889726,-0.064312,-0.027706167,-0.010114291,0.07416261,-0.017748643,-0.041048165,-0.04038393,-0.011236752,0.057247415,-0.07928921,-0.09803716,0.052124474,0.016793935,-0.008090904,0.06902496,0.05285952,0.10086415,-0.015192076,-0.04481348,0.15430866,0.058522638,-0.03847394,-0.00060607685,0.009196416,-0.030531265,0.049361873,0.005883335,0.07005215,0.09406271,0.029231194,-0.107320875,-0.022100406,-0.023629803,0.06541172,-0.03863861,-0.02719002,0.0714709,-0.034928195,-0.0077780313,-0.058718126,-0.07216414,-0.007669219,-0.08472561,0.06230856,0.05251891,0.006916252,0.04131187,-0.046812344,-0.08221014,-0.08000982,0.010111713,-0.008095455,-0.045184404,0.0074094688,0.018760625,-0.015541892,-0.074048005,0.037515372,-0.018799117,-5.9449154e-33,0.12830961,-0.09189749,0.044078805,-0.026816076,0.008173251,0.13734962,0.06804016,-0.013897084,0.0021323867,0.010654091,0.08728562,0.007997283,0.039226264,-0.021459471,0.040749613,0.010649601,-0.034094002,0.09341847,0.0113154035,-0.07737037,-0.006211276,0.052265096,0.064877845,0.020539507,0.02486585,-0.02621512,-0.0052611893,0.11727181,-0.031006685,-0.024276199,0.009490034,0.035915144,-0.007895068,-0.052789047,-0.03436421,-0.014060838,-0.008865617,-0.03390659,0.03373664,-0.06483519,-0.021156898,0.04172444,0.012619271,0.047012214,0.056238588,-0.023613475,-0.06982301,-0.063634105,0.003953764,-0.14797139,0.013142726,0.035527542,-0.05041586,0.0054737288,0.042461034,0.07250351,0.04804257,0.026242733,0.05150268,0.008579059,-0.06911705,-0.07975077,0.062476657,-0.012362909,0.021869216,-0.012163261,-0.010843779,0.03929608,0.04345219,-0.0007893618,0.025223944,0.04090027,0.026942477,0.07513375,-0.0014320775,-0.031272076,-0.039269373,0.02867694,-0.0061911913,-0.086157516,-0.020462504,-0.004830064,0.019631814,-0.055974126,0.047610905,-0.09987509,0.01380987,0.061514895,0.014226231,0.040838018,-0.032341532,-0.061933592,-0.062013537,0.054885533,0.059240263,-4.147611e-08,0.05231606,-0.0886638,0.005036462,-0.04687513,-0.03139007,0.10786015,-0.038473707,-0.019948052,0.07172381,-0.09754551,0.0497253,0.020413086,-0.05714354,0.09719901,0.016631378,0.017640527,-0.058370966,0.007228725,0.015056783,-9.846431e-05,-0.014528446,-0.008263635,-0.045938198,0.10517067,0.0066963485,0.022765089,-0.027336681,0.067891,0.050560113,-0.019893475,-0.10603389,0.079368226,0.028433397,-0.0578139,-0.07191496,0.0445977,-0.017450746,-0.049817715,-0.07653929,0.01990354,0.0055016326,-0.03449225,-0.014443767,-0.04200194,0.00021301556,-0.016638309,-0.0026526614,0.09182108,-0.0009926127,-0.038432,0.034235608,0.019809876,-0.040119685,-0.029462915,-0.09458892,0.030795053,-0.07882553,-0.08883717,0.026905052,-0.043901533,0.01965852,0.012582012,0.09612043,-0.012277819 +4.1.1.6,"The enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase.",384,0.99999994,-0.03467186,0.0117275715,-0.09388606,-0.01412727,-0.0063521313,0.011150193,-0.10415912,0.09033035,-0.012259214,0.0033259052,0.021683024,-0.10174331,-0.091161124,0.03971052,-0.123074695,-0.03160382,0.036814593,0.021812646,0.019530738,-0.026288891,0.035051607,0.09326887,-0.07428918,0.0019211554,0.03502738,-0.04407402,0.035269152,-0.07274356,-0.057956167,-0.080119364,-0.039160646,-0.046630338,0.06188658,0.027037894,0.008697024,0.09397837,-0.052574348,-0.05235271,0.12535203,0.02429957,-0.002760168,-0.08451643,0.01151198,-0.044828597,-0.024224607,0.008991283,-0.031748686,0.03463905,0.10769399,0.03852693,-0.03241519,0.044371758,-0.005899749,0.055862743,-0.036479346,-0.0041311667,0.024945827,-0.06354127,-0.08409517,0.0069185835,-0.025795057,-0.05305224,0.0039468515,0.019663863,-0.028331587,-0.014098579,0.0040790862,-0.04786492,-0.01869253,-0.019301334,-0.044483297,-0.08514962,0.019827196,0.02316505,0.010423546,-0.0012694395,-0.026737778,-0.06368367,0.062423486,0.0115989335,0.09779359,0.055824086,0.042098626,0.007041797,0.058455337,-0.0039294614,-0.023143586,0.06851958,0.041207276,0.07030499,0.020880794,0.064346075,0.05638568,0.024146946,0.008982133,0.063139744,0.039816566,0.08571549,0.023877887,-0.0430789,-0.015307195,-0.006617038,-0.02642056,-0.085675865,-0.050102297,0.0118023185,0.023159932,0.0020267274,0.079456486,0.07075939,-0.015054829,-0.02895804,-0.03717485,-0.05320224,0.04587827,0.026109962,0.03488323,-0.01657153,-0.006934502,-0.04844688,0.04038724,-0.028224993,-0.0291323,0.0044352794,0.055795744,0.06409325,-0.057309583,-1.18770985e-33,0.008260073,0.02603093,-0.032987066,0.023899153,0.037128795,0.0064513935,-0.04077492,0.058557186,-0.06624674,-0.05825261,-0.032157227,-0.016789185,-0.05349178,0.08786955,-0.053496514,-0.044048175,0.019253686,-0.04308468,0.012970423,-0.020072237,0.03668197,0.03947997,-0.10097219,0.07642952,0.0053486517,0.0051372824,-0.05965704,0.02340905,0.022049347,-0.03761225,-0.011958823,-0.056429636,-0.068488665,-0.024967201,0.098736614,0.009577002,-0.011218102,-0.005114464,-0.09096934,0.02123194,0.064622335,0.0052553695,-0.032421317,-0.13201685,0.043457534,-0.053286113,-0.06808767,0.10324773,0.03173044,0.019837325,0.09025655,0.027990967,0.030765021,-0.004136094,0.0056750826,0.020837054,-0.1126479,0.050943557,0.05520715,0.0067595514,0.020381967,0.02260608,0.032999005,0.040545393,0.0036820753,0.0073220073,-0.10714686,-0.015222404,-0.013030443,0.09384494,0.01910882,-0.030243192,-0.021510934,0.040868353,0.04846739,-0.034263346,-0.04356127,0.0072258725,0.0059555215,-0.035895217,-0.005253636,0.03575869,0.007174064,-0.026605481,-0.11168345,0.02131808,0.008088828,0.037881467,0.003717436,-0.026393954,0.039051313,-0.048661318,-0.09371606,0.08896611,-0.0056306687,-1.8857084e-33,0.10447717,-0.11802017,0.006418093,-0.016137896,-0.035863355,0.08508887,0.04405262,0.024781516,0.023987247,0.006304114,0.09315154,-0.0063572824,0.02806963,-0.019725624,0.048101306,0.043504298,0.0061645606,0.04496119,0.027229855,-0.012065107,-0.043329943,0.06521505,-0.02213985,0.014206025,0.031026013,-0.009796095,0.0042999326,0.09447035,-0.017454274,0.05892813,-0.026855368,0.0566604,-0.0033906796,-0.00282051,-0.09548856,0.096435875,-0.037631538,-0.0038806645,0.0060246903,0.040077206,0.007748289,-0.016063005,-0.021236222,0.086391024,0.052743927,0.0073180716,-0.0043188757,0.032701854,0.021148132,-0.063526444,0.03304845,0.045762863,0.01593771,-0.042905834,0.00016548157,0.063849546,-0.00013502272,-0.062532134,0.07454175,-0.08957479,-0.051937196,-0.03162515,-0.003264345,0.024353858,0.058334023,0.026244782,-0.060621038,-0.023786688,0.033625737,-0.049655885,0.0868256,0.007833521,-0.056639615,0.020274092,-0.0065474496,-0.079482876,-0.0077251033,-0.0027727475,-0.036520474,0.025956443,-0.045264293,-0.05269733,0.05927698,-0.02224548,-0.072188854,-0.07730056,0.03914238,0.053293813,-0.08650123,0.104291946,-0.053620934,-0.03595386,-0.09588156,0.05354268,0.044760376,-3.20952e-08,0.08937677,0.021575496,0.06759753,-0.0923344,-0.012964444,0.06824795,0.055046637,0.00097414386,0.010820443,-0.023514617,-0.089739464,0.020249296,-0.019305408,0.1138465,0.10271846,0.023483355,-0.07984919,0.031088144,-0.0078898305,0.021022158,-0.0068884483,-0.0063665253,-0.077432126,0.015982596,-0.08954692,0.047602117,0.052262273,0.040327217,-0.024468647,-0.0029445789,-0.080805354,0.09712295,0.03932295,-0.10824249,-0.05669381,-0.028532177,0.0026146506,-0.084711835,-0.033323918,0.015368732,0.02925168,-0.0441756,-0.050325673,-0.02320543,-0.059341654,-0.059108883,0.02445304,0.028730413,0.013652346,-0.019820508,0.11680644,0.0035708044,-0.05167511,0.010772935,-0.009092443,-0.043125056,-0.01941595,-0.06029301,-0.05274059,-0.056653295,-0.015191624,0.026126405,0.16488071,-0.05675789 +4.1.1.7,A thiamine-diphosphate protein.,384,1.0,-0.08089331,-0.008508355,-0.052845582,-0.008935192,-0.0099549685,-0.008899688,0.08867158,0.06044833,-0.010204869,0.030642731,0.026736205,-0.048694246,0.006689777,0.0569292,-0.01152731,0.015394125,0.011099636,-0.041505013,0.020707866,-0.049765196,0.005178324,0.12267674,-0.065429695,-0.021972936,-0.021461753,0.067434385,0.059812415,-0.013213148,0.0037130846,-0.08659743,-0.12188814,0.012667931,0.03196427,-0.04269946,0.03154372,0.06594522,-0.049162738,0.006926556,0.01582329,-0.033747587,0.126263,0.011330333,0.03322762,-0.018699003,-0.0757644,0.004035201,0.07852067,0.081025325,0.05880025,0.06895604,-0.061526455,-0.025555525,0.030837726,0.01387693,0.03475142,-0.044965696,-0.028472142,0.012775305,-0.03833213,0.026187284,-0.015264927,-0.042473573,-0.008844242,-0.04815847,0.17117983,-0.09913953,-0.008820532,-0.017523,0.04000238,-0.050130356,-0.032900088,0.021681247,0.051384714,0.035435114,-0.053553376,0.046780013,0.022324312,-0.030239535,0.069951884,0.012469383,0.008797224,-0.012904543,0.026385494,0.087267354,0.039287515,-0.030835873,0.01601314,0.045591533,-0.039443683,-0.05858424,0.018343266,0.009375835,-0.033803824,-0.0018618377,-0.104120106,0.03737714,0.00797313,-0.038440265,-0.07663245,0.026142927,0.08903679,0.020288698,0.0021568767,-0.058109432,-0.023168389,-0.018907152,-0.0023633735,0.04043457,-0.0017141431,0.040040616,-0.0026129305,0.040709913,0.045801893,-0.008293402,-0.042716052,0.017800042,0.010991428,-0.005722406,-0.04034189,-0.056963768,-0.04982591,0.026854457,0.036847793,0.034382503,-0.04761617,-0.03355186,-0.095208116,-2.2230784e-33,0.07071541,0.0539216,0.043020967,-0.017484106,-0.0184938,-0.011922019,-0.038998317,0.04833572,0.0014333928,-0.028858704,-0.020961048,-0.08400749,0.084453315,-0.009150999,-0.038594477,-0.09061495,-0.033317626,0.007078118,0.10663654,-0.046077006,-0.086670324,0.102290966,-0.06016048,0.022663027,0.01470431,0.0074642515,0.0061687194,0.03498647,-0.012059062,-0.0070122755,0.07563373,-0.05090983,-0.09404059,-0.07193445,0.0735814,-0.09375284,-0.028330285,-0.031441115,-0.069042675,-0.032223415,0.054083128,-0.0051815226,-0.029613292,-0.0144490795,-0.0033177834,-0.108701035,-0.03704339,0.034042478,-0.049540874,-0.006718976,0.02695159,-0.03760962,0.11432143,-0.05953667,-0.07911482,-0.026610846,0.010236068,-0.001361554,0.04803166,0.053076603,0.011230352,-0.0054337056,-0.13221513,0.062162194,-0.07170701,-0.0073548863,-0.12419155,-0.040874053,0.061654046,0.06484494,0.057801176,-0.020916007,0.07116711,-0.032153543,-0.07804834,-0.03471738,-0.045287777,0.05918875,-0.023804752,0.04823427,0.095876224,-0.038004152,-0.007299276,-0.02754372,-0.10930528,-0.032703955,0.09118197,-0.04138834,0.01619424,-0.03557237,0.05025907,-0.027462415,-0.061526995,-0.03263133,0.021615144,4.262859e-34,0.08965645,-0.08797283,0.04366342,-0.03858394,0.0033453282,-0.057531007,0.08571825,0.0088385735,-0.039410986,-0.051010437,0.10090465,-0.013583042,0.040143583,-0.05494334,-0.0004678554,0.12240701,-0.03752116,0.059963718,0.06787214,-0.014212277,-0.06711342,0.039587617,0.059169386,0.047719896,-0.035512965,0.025131794,0.03382383,0.0031276224,-0.039735194,0.100473315,-0.020388402,0.025186416,-0.062149014,-0.028382156,-0.091326736,-0.032251753,0.013432346,-0.087447256,0.0033955716,-0.00887085,-0.038586818,0.05670098,0.07864567,0.088383384,0.06332793,0.06600844,0.013713473,-0.019107353,-0.07996807,-0.018728126,0.04630545,0.010541479,0.007797401,-0.0075894357,0.025498688,-0.04259823,-0.036016036,0.02011304,0.042991944,-0.007973789,0.004900771,-0.08420613,0.00014969216,-0.000714559,0.036420736,0.08642689,-0.023579342,0.028929364,0.07375894,0.003395215,0.050824087,0.045550715,0.09741437,-0.029638162,-0.031944513,0.062842816,0.0016379859,0.07843737,-0.035189476,-0.0027150498,-0.03261278,-0.027323106,-0.064616755,-0.019386083,-0.003614757,0.009034124,0.040507123,0.053434446,-0.05227944,0.050296094,-0.09876313,-0.017010696,-0.040309936,0.09723824,0.105813116,-1.7993957e-08,0.028785702,-0.09492228,-0.025458025,-0.032958154,-0.018395964,0.084619135,0.013415192,-0.00010479627,0.1102944,0.039328806,0.023878831,0.0416585,-0.017178888,0.05973567,0.06453927,-0.018341351,-0.024615066,0.0040614037,-0.016355202,0.00702142,-0.010834695,0.0111402795,-0.0012487716,0.009495611,0.022178067,0.027372165,0.0017497846,-0.047776826,-0.0210248,-0.06116085,-0.00033317087,0.030861108,-0.012133413,-0.09617541,-0.01069815,0.07840893,0.0542489,-0.030803885,-0.05276984,0.017684039,-0.0050797258,0.02509206,-0.109584905,0.006026348,0.012833139,-0.020215685,0.013186039,0.119689025,-0.05961564,-0.07459989,-0.04184507,0.020418046,-0.012473562,-0.041026995,-0.051568758,-0.00893825,-0.055236664,-0.01527889,-0.045739975,0.02272791,0.042370535,0.02054589,0.07977227,-0.0334902 +4.1.1.8,A thiamine-diphosphate protein.,384,1.0,-0.08089331,-0.008508355,-0.052845582,-0.008935192,-0.0099549685,-0.008899688,0.08867158,0.06044833,-0.010204869,0.030642731,0.026736205,-0.048694246,0.006689777,0.0569292,-0.01152731,0.015394125,0.011099636,-0.041505013,0.020707866,-0.049765196,0.005178324,0.12267674,-0.065429695,-0.021972936,-0.021461753,0.067434385,0.059812415,-0.013213148,0.0037130846,-0.08659743,-0.12188814,0.012667931,0.03196427,-0.04269946,0.03154372,0.06594522,-0.049162738,0.006926556,0.01582329,-0.033747587,0.126263,0.011330333,0.03322762,-0.018699003,-0.0757644,0.004035201,0.07852067,0.081025325,0.05880025,0.06895604,-0.061526455,-0.025555525,0.030837726,0.01387693,0.03475142,-0.044965696,-0.028472142,0.012775305,-0.03833213,0.026187284,-0.015264927,-0.042473573,-0.008844242,-0.04815847,0.17117983,-0.09913953,-0.008820532,-0.017523,0.04000238,-0.050130356,-0.032900088,0.021681247,0.051384714,0.035435114,-0.053553376,0.046780013,0.022324312,-0.030239535,0.069951884,0.012469383,0.008797224,-0.012904543,0.026385494,0.087267354,0.039287515,-0.030835873,0.01601314,0.045591533,-0.039443683,-0.05858424,0.018343266,0.009375835,-0.033803824,-0.0018618377,-0.104120106,0.03737714,0.00797313,-0.038440265,-0.07663245,0.026142927,0.08903679,0.020288698,0.0021568767,-0.058109432,-0.023168389,-0.018907152,-0.0023633735,0.04043457,-0.0017141431,0.040040616,-0.0026129305,0.040709913,0.045801893,-0.008293402,-0.042716052,0.017800042,0.010991428,-0.005722406,-0.04034189,-0.056963768,-0.04982591,0.026854457,0.036847793,0.034382503,-0.04761617,-0.03355186,-0.095208116,-2.2230784e-33,0.07071541,0.0539216,0.043020967,-0.017484106,-0.0184938,-0.011922019,-0.038998317,0.04833572,0.0014333928,-0.028858704,-0.020961048,-0.08400749,0.084453315,-0.009150999,-0.038594477,-0.09061495,-0.033317626,0.007078118,0.10663654,-0.046077006,-0.086670324,0.102290966,-0.06016048,0.022663027,0.01470431,0.0074642515,0.0061687194,0.03498647,-0.012059062,-0.0070122755,0.07563373,-0.05090983,-0.09404059,-0.07193445,0.0735814,-0.09375284,-0.028330285,-0.031441115,-0.069042675,-0.032223415,0.054083128,-0.0051815226,-0.029613292,-0.0144490795,-0.0033177834,-0.108701035,-0.03704339,0.034042478,-0.049540874,-0.006718976,0.02695159,-0.03760962,0.11432143,-0.05953667,-0.07911482,-0.026610846,0.010236068,-0.001361554,0.04803166,0.053076603,0.011230352,-0.0054337056,-0.13221513,0.062162194,-0.07170701,-0.0073548863,-0.12419155,-0.040874053,0.061654046,0.06484494,0.057801176,-0.020916007,0.07116711,-0.032153543,-0.07804834,-0.03471738,-0.045287777,0.05918875,-0.023804752,0.04823427,0.095876224,-0.038004152,-0.007299276,-0.02754372,-0.10930528,-0.032703955,0.09118197,-0.04138834,0.01619424,-0.03557237,0.05025907,-0.027462415,-0.061526995,-0.03263133,0.021615144,4.262859e-34,0.08965645,-0.08797283,0.04366342,-0.03858394,0.0033453282,-0.057531007,0.08571825,0.0088385735,-0.039410986,-0.051010437,0.10090465,-0.013583042,0.040143583,-0.05494334,-0.0004678554,0.12240701,-0.03752116,0.059963718,0.06787214,-0.014212277,-0.06711342,0.039587617,0.059169386,0.047719896,-0.035512965,0.025131794,0.03382383,0.0031276224,-0.039735194,0.100473315,-0.020388402,0.025186416,-0.062149014,-0.028382156,-0.091326736,-0.032251753,0.013432346,-0.087447256,0.0033955716,-0.00887085,-0.038586818,0.05670098,0.07864567,0.088383384,0.06332793,0.06600844,0.013713473,-0.019107353,-0.07996807,-0.018728126,0.04630545,0.010541479,0.007797401,-0.0075894357,0.025498688,-0.04259823,-0.036016036,0.02011304,0.042991944,-0.007973789,0.004900771,-0.08420613,0.00014969216,-0.000714559,0.036420736,0.08642689,-0.023579342,0.028929364,0.07375894,0.003395215,0.050824087,0.045550715,0.09741437,-0.029638162,-0.031944513,0.062842816,0.0016379859,0.07843737,-0.035189476,-0.0027150498,-0.03261278,-0.027323106,-0.064616755,-0.019386083,-0.003614757,0.009034124,0.040507123,0.053434446,-0.05227944,0.050296094,-0.09876313,-0.017010696,-0.040309936,0.09723824,0.105813116,-1.7993957e-08,0.028785702,-0.09492228,-0.025458025,-0.032958154,-0.018395964,0.084619135,0.013415192,-0.00010479627,0.1102944,0.039328806,0.023878831,0.0416585,-0.017178888,0.05973567,0.06453927,-0.018341351,-0.024615066,0.0040614037,-0.016355202,0.00702142,-0.010834695,0.0111402795,-0.0012487716,0.009495611,0.022178067,0.027372165,0.0017497846,-0.047776826,-0.0210248,-0.06116085,-0.00033317087,0.030861108,-0.012133413,-0.09617541,-0.01069815,0.07840893,0.0542489,-0.030803885,-0.05276984,0.017684039,-0.0050797258,0.02509206,-0.109584905,0.006026348,0.012833139,-0.020215685,0.013186039,0.119689025,-0.05961564,-0.07459989,-0.04184507,0.020418046,-0.012473562,-0.041026995,-0.051568758,-0.00893825,-0.055236664,-0.01527889,-0.045739975,0.02272791,0.042370535,0.02054589,0.07977227,-0.0334902 +4.1.1.9,Specific for malonyl-CoA. The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 2.8.3.3 malonate CoA-transferase.,384,0.99999994,-0.060120605,-0.011562684,-0.010263256,0.019190757,0.051874977,0.05714192,-0.13899972,0.056056675,0.050961398,-0.09405091,0.027082441,-0.09243745,-0.08572527,0.01515797,-0.05676006,-0.024253817,-0.026300093,0.03398807,0.0063640834,0.018547008,0.08858741,0.053819783,-0.0054803407,0.032643836,0.02820167,0.07034846,0.05686347,0.018404037,0.009253226,-0.08349968,-0.056855056,-0.050914582,0.08395215,-0.0854979,0.042999163,0.06896229,0.009680505,-0.010791085,0.089606315,-0.022928448,0.108255655,-0.10122306,0.014406787,-0.029600522,-0.08541797,-0.07224137,-0.045586646,-0.024533866,0.0792058,-0.07117763,-0.06515965,-0.06374195,-0.06597296,0.075348854,-0.007266529,0.0067474106,0.0475596,0.010859354,-0.027121637,-0.019382471,0.0062790606,0.066011265,-0.008145878,0.043718223,-0.032344364,-0.050017696,0.036641803,-0.02598191,-0.0077382918,-0.030037561,-0.061326113,-0.052305862,0.011330926,0.0667385,0.08185345,0.0061363797,-0.020118183,-0.048584603,-0.010740471,-0.0037368636,-0.021413846,-0.0143960025,0.007168041,0.044290043,-0.05140711,-0.057889406,0.008947626,-0.027930398,0.051398557,-0.003526503,0.01664604,0.010940698,0.013314255,-0.058802735,-0.014312731,0.15642883,-0.016026795,0.018963125,0.066747315,-0.035826564,-0.030082593,0.023066044,-0.059671335,-0.06592164,-0.008373323,0.047694467,-0.0036321694,0.061873794,0.056109652,-0.069502875,0.0417203,-0.06795077,0.035528116,-0.052523665,-0.0025900325,0.09072503,-0.025962384,-0.03164692,-0.02431286,0.037239224,0.050617933,-0.07963972,0.023463191,-0.0016916504,-0.0028485884,0.044147942,-0.08594104,1.6021699e-34,0.07464518,0.057094485,-0.04864929,-0.030060874,-0.07805185,-0.057606917,-0.05990736,0.039616838,-0.03970354,-0.021672087,-0.036117703,-0.054892413,-0.0021379546,-0.031980347,-0.03240148,-0.016094228,0.033653956,-0.025200715,0.05407156,0.0072042425,0.06787559,0.018118534,-0.022032516,0.017909888,0.03267108,0.07794956,0.0029309527,-0.006505813,0.06602647,0.010953257,0.028253632,0.019447973,-0.064575486,-0.019360011,-0.0034500307,0.00066739274,-0.045721214,-0.004471303,0.03258365,0.0710406,0.120511405,0.05877248,-0.03076132,-0.034943752,0.06784441,-0.024410931,-0.09061604,0.07949548,0.1097611,0.10388708,0.038107574,-0.081030495,0.024281109,0.047177475,0.005797434,0.028324893,-0.034262955,0.027181005,0.020307833,0.027448364,0.03815519,0.09875234,0.0030329297,0.0019752104,0.0047001294,-0.0014535447,-0.0031459704,-0.036392577,-0.05793037,-5.098827e-05,-0.10338701,0.04161603,0.0052287146,0.052052803,0.036782134,-0.11521554,-0.051908415,0.017792022,0.08248383,0.0352005,-0.0074906917,0.025339084,0.035700005,-0.022910351,-0.06183758,0.044829022,-0.048925165,0.059459697,-0.07107675,0.024313381,0.10683086,-0.06834473,-0.008316553,0.05466606,-0.069171585,-1.2707133e-33,0.11097546,-0.12867855,0.045698825,-0.08569291,-0.07661014,0.03204846,0.04578308,0.021341885,0.019401873,0.09360392,0.06601737,0.0507753,0.07164892,-0.044472467,0.00798915,0.06006842,0.015165069,-0.017600073,-0.023783438,-0.036149062,0.031091593,0.05404963,-0.030813482,0.043237586,0.07455886,-0.053770028,-0.02503487,0.077878796,-0.025884023,0.086873494,0.008750987,-0.000679697,-0.031474475,-0.0056989407,-0.03922882,0.022504196,-0.026133085,-0.006223652,-0.0045678364,0.0004107811,-0.027517555,0.018690413,0.009190608,0.061201677,0.006622397,0.04383805,-0.05806946,0.0051116254,0.014775847,-0.03455656,-0.005351514,0.07728524,-0.05161102,0.012165677,-0.06032726,0.0513484,-0.016073335,0.0037723675,0.012473743,-0.07259243,-0.0748782,-0.03223414,-0.002010705,-0.043441966,0.09782857,0.16187266,-0.052265204,0.022241283,0.023425743,1.1563025e-05,0.07308383,-0.034262206,0.013390709,-0.030479115,-0.052639052,-0.013469448,-0.037456304,-0.015762392,-0.00229251,0.028675998,0.035731208,0.011860867,0.0048424834,-0.08027234,-0.061475188,-0.041580476,0.048236888,0.10152159,-0.059262957,0.02069841,-0.049364354,-0.055143934,0.05720381,0.03230896,0.096740946,-2.7034464e-08,0.000653911,-0.059798498,0.04174276,0.032609418,0.037710942,0.054818567,-0.08446066,-0.00433068,0.023490496,0.0048126853,-0.10533369,0.044185184,0.008908481,0.031225739,0.043858107,-0.0142869465,0.0055270893,0.057084385,-0.048837584,-0.087995894,-0.041368037,-0.027059222,-0.06993388,-0.010086575,-0.011053363,-0.050305355,0.0604787,-0.0021921443,-0.023088247,-0.07069682,-0.048031967,0.055391,-0.03263703,0.0054970947,-0.02963891,-0.0041383887,-0.032459956,-0.052871898,-0.042639382,0.042035077,0.1085663,-0.036640987,-0.07492683,-0.02505158,0.027205069,0.020765167,0.025429893,-0.02088322,0.008758904,-0.06000105,0.0822507,-0.04117372,-0.02842907,0.009612749,-0.04751956,-0.011872899,-0.004424287,-0.06021427,-0.038452625,-0.01704582,-0.018087177,0.02396757,0.15281945,-0.0036537205 +4.1.1.11,The Escherichia coli enzyme contains a pyruvoyl group.,384,1.0,-0.04875021,-0.088941626,-0.086020604,-0.035484746,0.021973569,0.044195477,-0.10212785,0.028759642,0.04213419,-0.039347127,0.045688175,-0.046293825,-0.082073875,0.080402076,0.036725145,-0.043945216,-0.11143012,0.015688859,0.054022036,-0.06935634,0.054161813,0.014950913,0.036460824,0.0067424835,-0.018115284,0.062505804,0.049746845,0.036398795,-0.042449582,-0.035330717,-0.03818478,-0.022129495,0.022302153,-0.07728384,0.18068916,0.04690231,-0.047703605,-0.029903239,0.107472725,-0.047789324,0.02932563,0.038059466,0.012422359,0.00954907,0.004782111,0.037937235,0.101199284,0.024937216,0.03815785,-0.050767824,-0.025028875,0.0010408267,-0.03413076,0.06452558,0.03593244,-0.012379268,0.05925333,-0.08668536,-0.025771108,-0.07255071,0.053715352,-0.019444086,0.015944313,0.021786802,-0.039410915,-0.034704924,0.09962243,-0.03208255,0.027472872,-0.044894084,-0.051647082,-0.0013796828,0.03238823,0.09572007,0.016123826,0.025689837,0.03626504,-0.05224256,0.017134937,0.041121427,0.027443388,-0.036881655,0.0062034396,0.07386038,0.026329232,-0.010662518,0.031007063,0.0017497152,-0.0048819566,-0.0069034924,-0.015281868,-0.03996441,0.002787712,-0.09434948,0.041133903,0.007616998,-0.023421915,0.005703449,0.030428419,-0.0689314,-0.040202457,-0.024853148,-0.014507767,-0.025613723,-0.061581235,-0.006706015,0.019541863,0.061712615,0.034622513,0.013950747,-0.04603478,0.056562442,0.0037586421,-0.0077250763,-0.02743256,-0.066269286,0.1025445,0.011771797,-0.056442935,0.08570735,0.048094746,-0.04107874,0.06442392,0.108422846,-0.061775602,-0.02322015,-0.107891485,3.0757019e-34,0.03146177,0.04194023,0.03453816,-0.067723274,0.06277633,-0.03898006,-0.06504729,0.0028741732,-0.10566286,-0.02332913,-0.11230161,-0.09741706,0.016591765,0.06514329,-0.052313235,-0.010280659,-0.1051676,0.057100702,0.04465468,-0.074878894,0.015053403,0.08360748,0.030174097,0.066405304,-0.021809584,0.03945229,-0.074224986,0.056565247,-0.009901916,-0.011926314,0.04053561,-0.07002955,-0.15014195,0.04416216,0.05997778,-0.03751542,-0.039397314,-0.0815163,0.035028685,0.035435054,-0.05369844,0.023570973,-0.029227622,-0.031496,0.035979014,-0.062816896,-0.09175467,0.015566384,0.006458392,0.072868854,0.0127851805,-0.015933827,0.032928452,-0.06876496,-0.062973514,-0.011414233,0.025497796,0.03391322,0.029110678,0.0103196055,0.04246196,0.14750527,-0.044604015,-0.010575757,0.009116489,0.0063867164,0.078083254,-0.0020140791,0.058942243,0.08780255,-0.032077342,0.0040295343,-0.022424795,0.045934953,0.06155518,-0.0029473791,-0.06552758,0.01326886,0.012312451,0.0060979784,-0.019257948,-0.05921462,-0.022275258,-0.027067414,-0.058269817,0.016061872,-0.045655277,-0.027207892,0.0032664887,0.037110034,-0.0034014317,-0.07076816,0.008007207,0.06584708,-0.03515886,-1.9449094e-33,0.05578098,-0.06101724,0.049169317,-0.07063669,-0.09026474,0.0034962068,0.032332074,-0.032356527,0.03300641,0.04175984,0.01989962,-0.052220333,-0.035240255,0.0022639737,0.041703187,0.034942683,0.01092819,0.04682023,0.040235415,0.012462759,0.039147433,-0.013520243,-0.026028698,0.045621183,0.02458306,0.029578632,-0.0016393604,0.05345611,0.032952815,-0.015841823,-0.014495693,-0.028703358,-0.04767129,-0.053593703,-0.06941613,0.04140301,-0.06382871,0.03680477,0.050928034,0.0061488887,0.085220195,0.09667894,-0.022641828,0.033601172,-0.030812882,0.035050847,0.040037453,0.012858738,0.004977755,-0.021033404,-0.0126340855,0.033394024,0.039797332,-0.06647006,0.0686541,0.020115044,0.03293802,-0.016545733,-0.04993889,-0.039590355,-0.0025468506,-0.08878654,0.0021469668,0.035494916,0.02458335,0.045912333,0.044010933,-0.02989032,0.025870094,0.012507886,0.0774788,0.022469988,0.006523662,0.03615579,-0.05443164,-0.0134134125,-0.051489886,-0.015350715,0.048911612,0.010627776,0.0469529,-0.0086980555,-0.032826725,-0.032569934,0.013792547,-0.07059338,0.01061419,0.09421937,0.06666781,0.012081949,0.05415664,-0.0057795965,0.07603602,0.025266359,0.05796898,-2.2253012e-08,0.08802345,-0.05528066,0.06328978,-0.016161531,0.05783761,-0.031528216,-0.026172495,-0.029905943,0.054788973,-0.006806004,0.033626277,0.01539044,8.208845e-05,-0.04127964,0.03886204,0.06487415,-0.075993195,-0.033529192,0.032650817,-0.0029720042,-0.05228812,0.0022381078,-0.13904777,-0.00018816267,0.029468225,-0.020001212,-0.046660483,-0.023214797,-0.06271921,-0.008789022,0.009516601,-0.032535963,-0.02013882,-0.03538601,-0.08515835,-0.032090604,-0.06853577,-0.028037233,-0.018927403,0.0067747324,0.033835307,0.015522788,-0.010610821,0.018972695,-0.0053425995,0.10019853,-0.078183144,-0.028346613,-0.06812916,-0.018386154,0.12126519,-0.0314059,0.00047703309,0.02411145,-0.18261632,0.066093616,0.009986104,-0.075268924,-0.0034936427,-0.08479673,0.019611586,0.011468807,0.16408242,-0.055593334 +4.1.1.12,"A pyridoxal-phosphate protein. Also catalyses the decarboxylation of aminomalonate (formerly listed as EC 4.1.1.10), and the desulfination of 3-sulfino-L-alanine to sulfite and alanine.",384,1.0,-0.017453019,-0.037675757,-0.017615207,-0.08360627,0.01433905,0.044523753,0.011323702,-0.022656372,0.04922996,0.06203642,0.006089631,0.00778967,-0.08146199,0.036266033,-0.019555094,0.043411825,-0.08336643,0.04813832,-0.005481202,-0.049214005,0.11937592,0.045785885,-0.053264745,-0.006637416,0.06529996,0.12964445,0.034967765,-0.002658953,-0.019908309,-0.093725756,0.029698724,-0.06450179,0.036629833,-0.019875888,0.011731447,0.10188389,-0.10315733,-0.08344031,0.032974385,-0.025228033,0.01605566,0.02497491,-0.016215127,-0.04607886,-0.08728358,-0.04539171,0.019003477,0.04448499,0.030957483,-0.07222368,-0.020386586,0.013438667,-0.037589133,-0.013880414,0.017986875,-0.0062694796,-0.028124098,0.0059237457,-0.05558949,-0.050566114,0.019472288,0.013512351,-0.008275347,-0.042344306,0.065750234,-0.0054010437,0.020357577,-0.05132357,0.05561869,0.01265346,-0.05817317,-0.08063852,0.044355214,0.024824893,-0.0156141,0.059694033,-0.04544259,-0.035831835,0.0015406166,-0.0016441181,0.01934113,0.025961677,0.012099265,0.04966775,0.06065909,0.008113357,-0.014985572,0.0063064755,0.043402635,-0.02440688,0.031625617,-0.050247546,0.051474653,0.031328596,-0.021977054,0.04363855,-0.008729564,0.05458705,0.0039295554,-0.007628325,0.008921117,0.08368084,-0.07814702,-0.10089434,-0.04070583,0.00031443042,-0.025798444,0.087893665,-0.045543786,-0.018662518,-0.085971944,-0.03361176,-0.0016014136,0.046330944,0.003359386,0.11692654,0.071183324,-0.017571805,-0.035067152,-0.012141296,0.0321399,-0.024061775,-0.0057058376,0.090786494,-0.023419114,0.046927005,-0.17145433,-5.3701535e-36,0.08126202,0.060580574,0.06927697,0.010317206,-0.015801502,-0.01801627,-0.067245424,0.068491615,-0.022385044,-0.02832629,-0.04752784,0.002934525,0.08789503,-0.007688357,-0.05866386,-0.08932652,-0.07436533,0.0799882,0.045882415,-0.029884497,-0.011843495,0.08663321,-0.026717579,0.04022032,-0.022968356,0.037144024,0.009918129,-0.027842863,0.043333534,-0.0024919591,-0.023174834,-0.09784167,-0.09485152,-0.016735617,0.0436433,-0.02528032,-0.0708995,-0.05731396,0.0027217276,0.0839634,-0.011628951,-0.059100866,-0.030530242,-0.028023483,0.0028826722,-0.074406035,-0.055674866,0.0463859,-0.0129722515,-0.021953234,0.06966339,-0.033965003,0.044415247,-0.03689594,-0.08705473,-0.022982053,-0.01958212,-0.046089783,0.042336453,0.041539002,0.050855618,-0.03166046,-0.050670817,-0.054591175,0.0025571624,-0.032697335,0.0050348225,-0.053428516,0.039012544,0.09967916,-0.05686223,-0.011680685,0.089951836,0.048830196,0.018793171,-0.0064226002,-0.068122365,0.004163663,0.021308865,0.06732103,-0.056677423,0.00012526795,-0.08895301,-0.042021256,-0.04183932,-0.02886234,0.013787943,-0.08365205,0.0025008114,0.05596809,-0.055705708,-0.06615333,-0.09410278,0.026351938,-0.006538099,-2.2642126e-33,0.079662316,-0.10174627,-0.016724719,-0.010818161,-0.05976523,0.010538093,0.10041033,-0.020911358,0.042052314,-0.020841112,0.054531973,-0.031392884,0.09469978,-0.05549107,0.04272388,0.03337583,0.024738213,-0.014155138,0.037169147,0.008437175,0.028206393,0.08850949,0.010117917,0.049606815,0.03657439,0.012019724,0.034375116,0.034456193,0.059773095,0.047871992,-0.005860183,0.017611817,0.028095681,-0.06120243,-0.14074048,0.065636106,-0.05135781,-0.0045165136,-0.00606247,0.0023682097,0.005340631,0.047211803,0.07097294,0.098348826,0.057482265,-0.0004513379,-0.023680365,0.034303002,0.02904153,-0.050402172,0.10116523,0.009994022,-0.0022922577,0.0014931955,0.042298503,0.058308434,-0.055754263,-0.03218655,0.019006632,0.084704295,-0.05451756,-0.068352334,0.036774974,-0.027795149,0.003101995,0.036668293,-0.024398806,-0.054210927,0.03817969,-0.0057394924,0.113009274,-0.01308519,0.022508547,0.06524637,-0.01540483,-0.038017415,-0.10115576,0.045354005,-0.012803266,-0.070517085,-0.043878168,0.0041380115,0.0040457034,-0.065008394,0.056067303,-0.07669802,0.04229861,0.13220967,-0.027657112,0.043900438,-0.01988519,-0.050792545,-0.011792116,0.11885603,0.047185335,-3.568178e-08,0.036706902,-0.01850843,0.02071846,0.004604423,-0.009450755,0.08221502,0.09342205,0.004151043,0.025441995,-0.06758293,0.039324313,0.0159268,-0.030934546,0.04304607,0.053274017,0.08101842,-0.05471653,0.032798618,-0.019257966,-0.05260986,-0.017567774,0.009044289,-0.10866083,0.022599705,0.032703824,0.024453009,0.028998924,0.01640685,-0.0049098516,-0.027643032,0.008999305,0.029349405,0.04922844,-0.07328179,-0.012611133,0.03141939,-0.030127887,-0.063218266,-0.010197742,0.008193227,-0.037951827,0.022557616,-0.048265535,0.003878541,-0.0077534006,0.044218972,-0.050637145,0.04020179,-0.08890647,0.014044413,0.10711502,-0.0036109076,-0.043130487,-0.069455236,-0.12765762,0.04113588,-0.033927385,-0.09068297,0.005279015,-0.037433114,0.020954024,-0.016535869,0.13908282,-0.027864983 +4.1.1.14,A pyridoxal-phosphate protein. Also acts on L-leucine.,384,1.0,-0.040315162,-0.09046834,-0.057187732,-0.09132818,0.10867768,0.056990456,-0.015011104,0.05013239,0.068203606,0.026579794,0.039826754,0.02599728,-0.054631073,0.053093746,-0.013870653,0.032437872,-0.06364707,0.014380819,-0.047893673,-0.070135504,0.11651466,0.04746431,-0.013584223,0.004625142,0.02774728,0.0762891,0.02189926,0.046916936,-0.033052165,-0.042751446,-0.021084558,-0.017544892,-0.03863522,-0.074562095,0.04980383,0.029738447,-0.118930876,0.025735123,0.012596516,0.013310618,0.049364768,-0.09244993,-0.036868066,-0.014886663,-0.08128391,-0.012351795,-0.0072087822,0.041679155,0.026708405,0.037174895,-0.013007059,-0.016080631,-0.02073625,0.010990055,-0.039074514,0.051968858,-0.03673914,0.04657299,0.013652767,0.009957686,-0.062306426,0.03152921,0.023629747,0.0303178,0.056855384,-0.032920994,-0.010998759,-0.047801755,-0.03950714,-0.02331395,0.0042486894,-0.058470733,0.08891862,0.028064696,0.059059337,0.034892283,-0.06708528,0.008614411,-0.03190291,0.009370048,0.0160514,0.016979834,0.00205016,0.08834926,0.016156655,-0.022231566,0.022675613,0.0050668833,-0.018273965,-0.042027287,0.032997154,-0.03238468,-0.04618463,0.055666048,0.01657821,0.03646882,0.013640281,-0.014060922,-0.07036879,-0.06160455,-0.037158884,0.008209482,-0.021212958,-0.038406253,-0.10628661,-0.0057805837,-0.027865963,0.058841206,-0.026152205,-0.075443685,0.010232078,0.03633237,-0.012303223,0.023345277,-0.016844107,-0.0048675123,0.07422972,-0.02378942,-0.07328329,-0.032378208,0.020435309,-0.053436007,0.0062603434,0.08750541,-0.052987315,0.008902584,-0.102380686,-1.7211542e-33,0.10744632,-0.000118484895,0.008660993,0.03083133,-0.035348892,0.008585849,-0.050513986,0.023416676,-0.034729593,0.005868077,-0.005589481,-0.04720448,0.07688391,0.00651747,-0.121668495,-0.014358761,-0.0580152,-0.03323397,0.075070105,-0.060506146,0.07683383,0.10779176,0.030492447,0.0732293,-0.021123944,0.08374391,-0.0045812214,-0.011078063,-0.011507146,0.00923425,0.012198457,-0.09542074,-0.05736461,-0.01135462,0.05415616,-0.020801922,-0.06586639,-0.05874818,-0.021953557,0.049117737,0.0070652803,-0.03333701,-0.033422712,-0.003216319,0.033334572,-0.0725472,-0.01914957,0.054093495,-0.0533301,0.030114513,0.08144843,-0.10197844,0.033595126,-0.0079590855,-0.13054803,0.003121883,-0.09524959,-0.050784025,-0.018458575,0.045051992,0.09172624,0.04246404,-0.06744529,0.043921303,0.031403743,-0.068268724,-0.04581967,-0.08033716,0.012030797,0.036523715,0.012802578,-0.05121914,0.10222801,0.029023675,0.019222466,-0.0014370598,-0.06850996,0.09691755,-0.020608542,0.08509037,0.056293968,-0.082801886,0.0035499937,-0.030328628,-0.046215948,-0.058635015,0.0122090345,-0.15968615,0.031181913,-0.017457139,0.02755666,-0.0922601,0.0035555682,0.024028622,0.011931302,-6.373786e-34,0.07435955,-0.111617066,0.13169071,0.03758874,-0.024935191,0.027601575,0.062979765,-0.0031167557,0.06446989,0.02474531,0.034211814,-0.011842757,-0.02680877,-0.10197995,0.042575467,0.019212049,-0.00312462,-0.021554101,0.06409443,0.08153979,-0.0356525,0.03912029,0.009313401,0.04715742,0.09874869,0.04780941,0.047188338,0.021467218,-0.0178853,-0.0071060145,0.008118805,0.06953515,0.0029339008,-0.09878271,-0.055017,-0.004928111,-0.06346157,-0.00954984,-0.015791774,-0.06442464,-0.025822006,0.0020587516,0.060002975,0.006002706,0.050906397,-0.00045801335,-0.024302999,-0.016391449,-0.002635011,-0.053803824,-0.00011506438,0.010617095,0.0042145303,-0.029773088,0.07028038,0.03009495,-0.017293902,0.018704755,0.07497382,0.001992161,0.025077341,-0.050362043,-0.041733325,0.091944955,0.04299324,0.08137896,0.015766243,-0.02760071,0.082963005,0.062778704,0.10004015,0.014211033,0.05364568,0.071124665,-0.07903009,-0.021200275,-0.052669153,0.01635448,-0.0026882882,-0.023602152,-0.04622509,-0.03817132,-0.04841586,-0.108468,0.037230097,-0.050250757,0.025246147,0.09553029,0.004517964,-0.026737466,0.0012914777,-0.02677817,0.003084559,0.05362109,0.11527298,-2.375034e-08,0.06378211,-0.057544637,-0.009668639,-0.04938563,-0.014264184,-0.045484826,0.10702758,0.008756569,0.056862827,-0.003729519,-0.009271936,0.013481077,0.06931712,-0.042123888,0.076986894,0.07494791,0.003946988,0.012516011,0.009739411,0.0012652751,-0.028910259,-0.019211553,-0.068549074,-0.009709933,0.041555084,-0.07068719,0.03311563,0.059167705,0.019274723,-0.04284384,0.05735124,-0.035423458,0.046844013,-0.11324513,0.012619403,0.08653704,-0.024948183,-0.059122343,0.015010358,-0.010101944,-0.048392408,0.051959135,0.030115888,-0.026349084,-0.020441672,0.0058058873,-0.029300133,0.0094530415,-0.047062717,-0.024223717,0.03600021,-0.043997083,-0.06531386,-0.07574001,-0.093297765,0.044283003,0.03694714,-0.051912516,0.061681155,-0.10776811,-0.04221178,-0.010477006,0.086776085,-0.024590986 +4.1.1.15,"A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.",384,0.99999994,-0.008267769,-0.09275802,-0.07981809,-0.06399855,-0.0015544372,0.088792935,0.02652799,-0.02140297,0.07194955,0.07014131,0.003547968,0.032642357,-0.09722281,0.08543387,-0.016448013,0.049820267,-0.089766555,-0.026786603,0.03443355,-0.06295194,0.07800786,0.008032184,-0.0027587456,-0.02382343,0.030725747,0.12134163,0.046788502,0.0055018514,0.0081590405,-0.042282753,0.0085499985,-0.04615846,-0.042038415,-0.026941318,0.052763917,0.09053893,-0.15606003,-0.041271374,-0.015779136,-0.017523272,0.08189871,-0.03317518,-0.05671603,0.028719567,-0.043039292,0.014041411,0.021770751,-0.0021230974,0.038746238,-0.057778295,-0.08091189,-0.03523955,-0.0014388565,0.03090761,-0.06470697,0.0637136,-0.0340422,0.08694092,-0.041116267,-0.013539885,-0.11114579,0.022749057,0.034950774,-0.0128652835,0.06647629,0.023776181,-0.03136249,-0.1053648,-0.09516427,-0.023721537,-0.012735615,-0.069043435,0.07102255,-0.04927343,0.006264959,0.037332073,-0.029587496,-0.010461592,-0.03355261,-0.05172427,0.02564812,0.017733322,-0.008410019,0.08452049,0.10026751,-0.019770699,0.013142397,0.07728719,-0.018196778,0.031064402,-0.016796093,-0.07047486,-0.021516139,0.010861635,0.00062050635,0.007227491,-0.00061777927,-0.009056038,0.03042855,-0.034682404,0.055045415,0.064671025,-0.010815919,-0.012577532,-0.042699058,0.085290626,-0.037958432,0.025576603,0.0037861792,-0.051051136,-0.08379694,0.035572294,0.017633133,0.046481404,0.014072554,0.021717062,0.031319786,0.037059244,0.014303993,-0.00925261,0.05845669,-0.044558458,0.0019159613,0.04605664,-0.0019332456,0.014126696,-0.17759554,-1.6988175e-33,0.06465526,0.0038180847,0.027019262,-0.022153826,-0.013395515,-0.0015432247,-0.022961268,0.01818644,-0.012680162,0.010614544,-0.0050744936,-0.07184635,0.060299207,0.046770856,-0.056271933,-0.0036985436,-0.075311296,0.041422553,0.06831655,-0.07259586,0.036812063,0.05305386,-0.03827947,0.06572947,-0.03748281,0.044197407,-0.049966842,0.029186938,0.009477296,-0.0015060338,-0.049977154,-0.10106575,-0.11018354,-0.0405511,0.019043619,-0.042713102,-0.014372409,-0.080981635,-0.021680465,0.05805617,0.023159418,-0.06264178,-0.0076149045,0.022502584,-0.034990225,-0.0610988,-0.05517948,0.029562483,0.06032478,0.0022626638,0.07851977,-0.13142052,0.09587052,-0.027494287,-0.084089786,0.016380994,-0.09938498,0.009228245,0.06572995,0.027688745,0.08798407,-0.03940167,-0.06155561,0.007307513,0.041630853,-0.010131794,-0.009341497,-0.074169375,0.0033482437,0.059331074,-0.024869733,-0.021369511,0.068741664,0.036990006,0.01732116,0.013101718,-0.046079174,0.043620132,-0.018196998,0.043814514,-0.009713003,-0.08039192,-0.021562954,-0.0063735126,-0.004483351,-0.007641494,0.070209675,-0.07597112,-0.04800582,-0.03127234,0.046223264,-0.08123608,0.017881261,0.007075836,-0.016166005,-5.5735394e-34,0.0036817433,-0.08093678,0.0996961,-0.05121661,-0.058186553,0.023203865,0.09488008,-0.02488244,0.025897307,0.0074427575,0.015005573,-0.013051705,0.05138782,-0.04351968,0.01892013,-0.023139175,-0.034852736,-0.00882376,0.06984281,0.023161178,0.0018312645,0.07774479,0.0011949062,0.06415544,0.07326016,0.052067347,0.00017949392,0.036713973,-0.013577452,0.06719813,-0.029359745,0.08377928,-0.04932112,-0.10534471,-0.045919515,0.039077383,-0.073483594,-0.05215912,-0.0671876,0.0057718246,0.024736758,0.047970515,0.1064374,0.049221843,0.029421126,-0.0057056895,-0.015151833,0.011812248,-0.04061515,0.0048979316,-0.018514581,0.045317918,-0.027437197,-0.014438279,0.017002102,0.046411015,-0.05602104,-0.020800024,0.019992802,-0.035773322,-0.010519917,-0.05923057,0.009266555,0.06558592,0.047968525,0.054027375,0.034924928,0.0020104283,0.07264737,0.048973184,0.0740554,0.08046039,0.06321714,0.08453793,-0.023922633,0.016918212,-0.07759956,0.056985427,0.05663184,-0.04241271,0.011110712,-0.0014414963,-0.0787514,-0.0738791,0.024182722,-0.06233122,-0.0001640504,0.11787223,-0.0031752507,-0.063550524,-0.015238143,-0.041640814,-0.026421508,0.055388365,-0.03377506,-3.44498e-08,0.0416692,-0.057710256,0.034337435,-0.054165665,-0.004013149,-0.05770863,0.07129746,0.010103595,-0.01149344,-0.011004417,0.040337253,-0.052860256,0.03929108,-0.014887047,0.038642745,0.07920464,-0.028533375,0.08689948,0.01591189,-0.07184599,0.00028239956,0.0114817275,-0.079604164,0.0691972,0.11886551,-0.014089887,0.03437747,0.07404324,-0.018573288,-0.044982776,0.037022486,0.010557168,0.056352407,-0.050848577,-0.0220809,0.021570053,-0.004221366,-0.009094928,-0.02953136,-0.001982456,-0.023347398,-0.018880174,-0.024947815,-0.022010988,-0.030635692,0.052911565,-0.029792653,0.008362828,-0.011911701,-0.0782592,0.05544072,0.006440414,-0.07076775,-0.042950884,-0.07035037,0.0062306644,0.01638087,-0.044237107,0.032983214,-0.1159639,-0.0030486754,0.07483677,0.14415236,-0.081087664 +4.1.1.16,A pyridoxal-phosphate 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+4.1.1.17,A pyridoxal-phosphate 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+4.1.1.18,A pyridoxal-phosphate protein. Also acts on 5-hydroxy-L-lysine.,384,1.0,-0.03287308,-0.14758068,-0.018721985,-0.041191578,0.10939003,0.0372732,0.014330148,-0.021684567,0.05421472,0.05919112,0.026845414,0.049150657,-0.070015214,0.070372865,0.015310334,0.07512002,-0.10064197,-0.020565558,-0.027057111,-0.06265295,0.11662436,0.039074607,-0.023429897,-0.0016859436,-0.0052838475,0.031017024,0.05813032,0.054651562,-0.039722763,-0.057085186,-0.031380303,0.008722229,-0.054881327,-0.075402595,0.00020970925,0.10072823,-0.11505283,-0.015509729,0.06251649,0.018716512,0.060305875,-0.11163839,-0.039981216,0.0055726757,-0.070055395,0.017582256,0.037628587,0.06599965,0.066693455,0.017094292,-0.06480573,-0.031872433,-0.057350535,-0.038667046,-0.084957495,0.0062990757,-0.045090754,0.055926178,0.003997605,-0.010283705,-0.037855964,0.05629301,0.043027375,0.037849866,0.05859792,-0.04741565,-0.013567358,-0.029478062,0.0060862056,-0.025911372,-0.016452257,-0.06070005,0.13874239,0.021538807,-0.007533676,0.051630124,-0.029459683,-0.023000672,-0.01242853,0.01234485,-0.020257762,0.016909964,0.02707049,0.11106301,0.043029495,-0.039505407,-0.020689888,0.017255848,-0.02253746,-0.05655124,0.020215392,-0.04182866,-0.009428205,0.06864521,-0.032461423,-0.00976342,0.021851793,-0.045411598,-0.069774255,-0.052682735,-0.035144188,0.0026664683,-0.0035866622,-0.0032597561,-0.03084903,-0.018145615,-0.013308761,0.026135873,-0.039483316,-0.07124817,-0.043745853,0.049535714,0.004768424,0.010950035,0.015233012,0.032404806,0.014291681,-0.015618986,-0.0528439,-0.022114707,0.027318351,-0.0050318604,0.0044340612,0.07405178,-0.10730844,0.016661514,-0.068824485,-1.8395247e-33,0.05635639,0.035546035,0.0473854,0.042961985,-0.013705756,0.005038953,-0.07108002,-0.026190812,-0.005031549,0.020673502,0.0022395398,-0.012996468,0.1104417,0.023510614,-0.090603985,-0.012793125,-0.098278664,0.03044102,0.08723007,-0.008584689,0.026203983,0.099521436,-0.0060960962,0.069265544,-0.055971906,0.10456698,0.0042982926,-0.003253978,-0.0020978358,0.012821221,-0.048261695,-0.10411257,-0.049804207,-0.042298768,0.047187373,-0.03487557,-0.033561077,-0.06722352,0.0062552677,-0.0029124334,0.016856702,-0.04591643,-0.045843806,0.023194836,0.01909925,-0.05806783,-0.068904884,0.050490662,-0.067248456,0.018882707,0.08022392,-0.10394595,0.07777999,-0.022261694,-0.12678035,-0.039034717,-0.06440569,-0.040447347,-0.017280234,0.06290807,0.08348144,0.023745123,-0.019967008,0.0047841445,0.0052347146,-0.025836693,0.018401166,-0.08651927,0.039887268,0.04046294,-0.0004202362,0.024425752,0.13069113,0.052577253,0.03466528,0.006826128,-0.04313217,0.044382267,-0.028554134,0.09454108,0.026202688,-0.100556076,-0.020746868,0.022740277,-0.012840056,-0.011724516,0.04701321,-0.103619754,0.015777985,-0.007560396,0.03684161,-0.1439788,0.018195834,0.030227276,-0.032153875,-2.5065867e-34,0.04876562,-0.08451514,0.0837313,0.0016056221,-0.02007614,-0.025061926,0.09672035,-0.030499475,0.034292355,0.012791181,0.05911829,-0.0018616797,-0.02027016,-0.048140712,0.003856266,0.05191252,-0.009198991,-0.017822841,0.044146262,0.056088634,0.03305718,0.0046149422,0.045428965,0.07713856,0.10454415,0.08224991,0.0028166152,-0.01597922,-0.020593518,0.03739047,0.01823393,0.020790178,-0.005502554,-0.106996216,-0.016965311,0.018647648,-0.07744181,-0.018363334,-0.017155753,-0.06524298,0.021137986,0.0076738377,0.06177925,-0.0013625006,-0.008539443,0.049552128,-0.0057504848,-0.004485106,-0.036554445,-0.027167147,0.0022492562,0.029522158,-0.015639052,-0.015751248,-0.0022826788,0.03659167,-0.051331233,0.051310223,0.004203436,0.05579375,-0.014817544,-0.055534087,-0.014429956,0.07909228,0.029526765,0.056578383,0.012181135,0.008523556,0.050652068,0.040636756,0.09355997,0.03294224,0.09115185,0.09973718,-0.057705604,0.009493921,-0.02999085,-0.023440491,0.0003391678,0.0017393157,-0.015232753,-0.025257159,-0.037216604,-0.07892902,0.020149084,-0.05926515,0.025650764,0.10818188,0.04932917,0.00873676,0.036655635,-0.033259645,-0.043641657,-0.015615815,0.11403932,-2.6372293e-08,0.061039656,-0.074753165,0.035238206,-0.067833096,-0.037334185,0.007809014,0.04566073,0.019154659,0.069178246,-0.01162247,0.043244284,0.007064286,0.041082613,-0.026246896,0.015321068,0.043176048,-0.018892625,0.053768888,0.0083711,-0.070132755,-0.046190258,-0.011541614,-0.061969884,-0.0008871247,0.06786863,-0.044412933,-0.020339424,-0.0076310663,0.015324968,-0.05912884,0.083584696,-0.023827605,-0.009521761,-0.071378924,-0.031484205,0.11159805,-0.037110362,-0.025529323,-0.03264084,0.027492462,-0.1061118,0.006223295,-0.021963093,-0.018724134,0.017031033,0.033806898,-0.06927039,0.0001543518,0.011607069,-0.034418102,0.028805317,-0.017947562,-0.052878946,-0.077570856,-0.1193707,0.020675682,-0.017523214,-0.03009011,0.026244303,-0.12091302,-0.074000895,0.03091163,0.12916704,-0.059561986 +4.1.1.19,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +4.1.1.20,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +4.1.1.21,"While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.",384,0.99999994,-0.014241962,-0.062265374,-0.064606585,-0.057344016,0.011285988,0.018624619,-0.021637915,-0.0023341598,0.03632361,0.005041408,0.03674989,-0.056025676,-0.049763568,0.056365084,-0.04755924,0.060987044,-0.075174645,0.047507733,0.038009513,-0.056836095,0.08336931,0.032014374,-0.04374465,0.031901225,-0.017283192,-0.068712085,0.05318021,0.017329749,-0.05213893,-0.09344678,-0.08013796,-0.057911836,0.07328087,-0.057601493,0.044762038,0.07071364,-0.0403937,-0.10380736,0.07609752,-0.03968566,-0.008812485,-0.010665199,-0.008034526,-0.028164156,-0.014407959,-0.026506867,0.033790626,0.05914558,0.057270795,-0.06052889,-0.052244343,-0.018221058,-0.022463825,-0.07209541,-0.017132541,0.028149132,-0.06784416,-0.042122666,-0.031611037,0.018819392,-0.016880933,0.06109098,0.030320166,0.013018403,0.007825145,-0.02432812,0.011364139,-0.016120493,-0.07117729,-0.009798154,-0.05799643,-0.10905274,0.020331882,-0.02689974,-0.033013895,0.003693256,-0.008758354,-0.042107224,-0.01987981,0.05543546,-0.08388499,-0.07800459,-0.00081842334,-0.081651546,0.018861216,0.028847374,0.037356615,0.071185604,-0.00119819,0.055796504,0.07584493,-0.008134456,0.075242765,-0.02121583,0.01423251,0.009306621,-0.0379235,0.109071426,0.043917976,-0.09723993,0.008512169,0.0683955,-0.025196692,-0.011436822,0.028742367,-0.010015302,0.036711473,0.044068236,-0.033200655,-0.04013298,-0.07454537,-0.0035300746,-6.372445e-05,0.039478756,0.0024677422,0.059510008,-0.0028519013,-0.024775699,-0.03285651,0.041397505,0.024569219,-0.043703474,0.0005886066,0.037461262,-0.069267765,0.021669712,-0.048802495,4.0355643e-33,0.011698463,0.033617564,0.021783408,-0.01514367,0.040796425,0.031953286,-0.07785082,-0.0114827445,-0.050745256,-0.050708197,-0.11525707,-0.064355426,0.030858323,-0.0612997,0.016778406,0.0066203056,-0.07417727,0.027577497,0.07726636,0.057426747,-0.005045261,0.04162105,-0.058917694,0.013550778,-0.02769239,0.07859514,0.002358241,0.017109234,0.0130101815,-0.011668428,-0.038373552,-0.035541583,-0.038982686,0.02351133,0.052789878,-0.068944916,0.03290687,0.016001327,-0.00597692,0.05057068,0.017912135,0.03996945,-0.047281023,-0.009511386,0.08994803,-0.040541112,-0.0644219,0.062553644,0.050893217,0.07505855,0.0048940834,-0.013083485,0.1294451,-0.07562466,0.031483922,0.010544808,-0.06358558,0.015411533,0.03288505,0.07056386,-0.07190593,0.04574181,-0.026152577,0.027230348,-0.025137572,0.06599764,-0.08837577,-0.076250434,0.012984719,0.12089503,-0.02016925,-0.07253985,-0.0035039652,-0.007763325,0.038733523,-0.05793876,-0.10622494,-0.013014344,-0.033662826,0.02354678,0.00037044947,0.071384795,-0.03145067,-0.0084538665,0.03831458,0.0709441,-0.017561225,-0.008867555,0.025104873,0.14632079,0.079163425,-0.08409961,-0.033867687,0.016786158,0.058856327,-5.4471854e-33,0.10098928,-0.10262552,0.020548917,-0.07113278,-0.104106635,0.07809345,0.04221304,-0.06908085,0.09422529,0.015798962,-0.035598386,0.02577718,0.009908545,-0.053418986,-0.07796983,-0.005463841,0.070528954,0.04715478,-0.03530834,-0.06065703,0.023372957,0.030795686,0.03690713,-0.006631559,0.034112044,0.04213534,-0.042199492,0.04774953,0.049529187,-0.031360492,-0.02865336,-0.040230334,0.007818831,-0.033104412,-0.010530125,0.025506562,-0.04504087,0.042278416,0.027074583,0.034547366,-0.06363661,0.08068644,-0.019438773,0.06435699,-0.036810253,0.04519139,-0.06919472,-0.0023534424,0.013901794,-0.09293392,-0.0080549475,-0.021149177,0.0022141356,-0.05863942,-0.005424102,-0.013922278,0.023916615,0.06632776,-0.0050786217,0.03383856,0.010710423,-0.044253472,0.01729858,-0.088432945,0.06910963,0.015288159,-0.008818252,0.070267536,0.050157096,-0.009860645,0.025734132,0.04535094,-0.026238607,0.037753295,-0.010833431,-0.025540821,-0.0850727,-0.06289074,0.072557785,0.016626352,-0.025822982,0.029822106,-0.03577215,-0.02644949,-0.062319838,-0.083104454,0.09010202,0.09137803,0.031772014,0.04931981,0.054322686,0.0301185,0.013023915,0.03392229,-0.031688444,-4.7444075e-08,0.108945906,-0.106553905,0.032473955,-0.094197534,-0.022586394,0.042019073,-0.036775365,0.01363759,0.13624589,-0.03397433,-0.0011725144,0.049122483,0.0806047,0.09576609,0.05323322,0.008344128,-0.044309553,-0.06170476,0.02053224,0.000585857,-0.07229942,0.014959442,-0.14392167,0.07323825,0.033238012,-0.05158912,0.051864397,0.02170301,-0.021902483,0.0334865,-0.038710397,-0.02075762,0.011973972,-0.029651979,-0.027048044,-0.018378787,-0.015580799,-0.03119927,-0.054430075,-0.022913076,0.03995559,-0.0865839,-0.027413215,0.0072289035,0.013082548,0.032043915,-0.00675305,0.008190204,-0.0012682579,-0.021941716,0.041845817,-0.015638562,0.018636413,-0.037139717,-0.041737985,-0.032612726,0.036831312,-0.12805933,0.045213345,-0.0050967536,0.03417935,0.057322394,0.18803942,-0.015004818 +4.1.1.22,The enzyme from animal tissues contains a pyridoxal 5'-phosphate cofactor. The bacterial enzyme contains a tightly-bound pyruvoyl cofactor.,384,0.99999994,-0.03172821,-0.085320696,-0.025250955,-0.073147886,0.035525225,0.02272091,-0.08249329,0.011164791,0.00019431803,0.053943433,0.04797473,-0.036958113,-0.083751544,0.13888681,0.004291903,-0.026151568,-0.10293066,-0.04137106,0.059118837,-0.027146436,0.06616959,0.08986944,0.0014066816,-0.0027579316,-0.013579154,0.060520668,0.060348064,-0.005850763,-0.013332163,-0.030891575,-0.045010988,-0.026070736,-0.03847612,-0.08650943,0.09572567,0.042409234,-0.07271314,-0.03225755,0.10931437,0.04704261,0.0625144,0.010981169,0.0032650046,0.034685045,-0.020208845,0.027069744,0.073840894,-0.00697266,0.07252665,-0.027283035,-0.12244922,0.025003288,-0.052957095,0.01581945,-0.03863311,-0.019120082,0.04945878,-0.04828437,-0.04435151,-0.038878255,-0.01965037,-0.035938017,0.05742756,0.015453707,-0.014520357,-0.012376071,0.01028614,-0.0727574,-0.06710018,-0.0063044536,-0.061195552,-0.047771763,0.070777185,0.038307924,-0.04743393,0.03581737,-0.022620214,-0.07320627,0.03279454,0.013272748,0.00617916,-0.015140125,0.0055887382,0.0627225,0.020449564,-0.00978138,0.04213982,-0.008007868,-0.050399628,-0.03993292,0.021787819,-0.08031355,-0.0017980303,-0.059459817,-0.024478177,0.0012094235,-0.032781783,0.051806875,0.03242323,-0.091563635,-0.043020222,-0.030922635,-0.005502471,-0.018372567,-0.06352034,0.009097334,0.0003020632,0.05670171,0.082602985,0.07432249,-0.063079365,0.085991174,-0.053180326,-0.008065126,0.049598683,0.019024821,0.052313786,-0.031417277,-0.052132178,0.054658595,0.031156443,-0.10323283,0.073385306,0.06514472,-0.06399126,-0.006014754,-0.08983225,2.1949033e-33,0.04935298,0.028956609,0.030853951,-0.05138887,-0.0038282375,-0.012208992,-0.07906636,-0.017037531,-0.06953067,-0.002616291,-0.056773745,-0.0075328946,0.03637703,0.040207207,-0.047984913,-0.0032500944,-0.09772169,0.03309726,0.0804721,-0.02790011,0.06278204,0.07609183,-0.007335253,0.10911466,0.012784277,0.013639098,-0.04428973,0.042777155,-0.011219888,-0.017671408,0.003013551,-0.117562935,-0.03691421,-0.008354541,0.07274368,-0.05576267,-0.058968652,-0.07596364,-0.020230602,-0.013823713,0.021244956,-0.03465376,0.039317247,0.019012745,0.041760135,-0.08881203,-0.10315658,0.051834647,-0.022392035,0.06411745,0.04660295,-0.009860779,0.080948494,-0.03381639,-0.09181955,-0.002076957,0.0008824531,-0.009676851,0.012229728,0.03907733,0.038730558,0.030720811,-0.00520341,-0.0057880133,0.016675042,0.005892877,0.035482004,-0.068929106,0.061588097,0.10787079,-0.047148418,0.020862512,-0.0142551465,0.025225224,0.0015543855,0.0011861542,-0.013175833,0.037899226,0.012631013,-0.016721152,-0.035911743,-0.036962558,0.024063207,-0.011067575,-0.043138064,0.012149798,-0.011022517,-0.043559115,0.002220544,-0.028400786,0.078070894,-0.09947661,-0.04225321,0.03952099,-0.0031946532,-3.0844028e-33,0.095880225,-0.09431425,0.09095924,-0.06930948,-0.07344931,0.06990678,0.08767694,-0.015272273,0.052505556,0.009225136,0.025527906,0.012633439,0.032006335,-0.017805064,0.03992492,0.05331545,0.012426284,0.061796684,0.060351636,-0.008050668,0.02074634,-0.01917582,0.029095577,0.020141656,0.05529735,0.07728185,-0.041474838,0.013281121,-0.0072423685,-0.042266022,-0.031856235,0.021299742,-0.007340005,-0.11484026,-0.058825377,-0.05596739,-0.07503963,-0.008750999,-0.015473538,-0.02793465,0.07116549,0.07645533,0.024385143,0.03159084,-0.051597316,-0.0006400633,-0.040542185,-0.004504,0.0070205797,-0.0023644846,-0.021650085,0.039451905,-0.012241843,-0.06366887,0.050922792,0.042573906,-0.008682797,0.024663046,0.018548006,-0.0151390955,-0.020337898,-0.0677243,0.040020954,0.069441825,0.028796552,0.05905264,0.06439501,-0.009170924,0.019577783,0.031591434,0.014686877,0.089588724,0.021442328,0.07660005,-0.06868311,0.045744937,-0.031972904,0.009213838,0.067927875,0.04607789,0.05030668,-0.032892846,-0.06591103,-0.026133496,0.0012505746,-0.0668644,0.042863026,0.11640217,0.08809638,0.01706817,-0.005383088,-0.015135391,0.026652925,-0.009434626,0.05081809,-3.1798862e-08,0.04993561,-0.025847713,0.057355035,-0.034741744,0.05184152,0.046133388,-0.012016102,-0.050029635,0.07946558,0.012859579,0.03905873,0.006121159,-0.019532045,0.007657118,0.021140523,0.05409865,-0.08992805,-0.043773364,0.029801976,-0.026636066,-0.083711125,-0.0016861644,-0.09625657,0.063422725,0.072424464,-0.020365316,-0.03295528,0.04674868,-0.073052205,0.018586272,-0.03238973,-0.013834764,-0.02826849,-0.11182867,-0.07306988,0.032170717,-0.015296518,-0.05925147,-0.07916756,0.07487499,0.016803944,-0.037250265,-0.024024926,-0.033361424,0.0102241505,0.07145066,-0.039896056,-0.0015969052,-0.023641603,-0.038035374,0.029512124,-0.010537409,-0.064640634,-0.051608086,-0.1788359,0.042546313,0.031495485,-0.09003738,-0.03091445,-0.06744181,0.01949762,0.058615055,0.18730955,-0.004107308 +4.1.1.23,The enzyme from higher eukaryotes is identical with EC 2.4.2.10 orotate phosphoribosyltransferase 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+4.1.1.24,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +4.1.1.25,"A pyridoxal-phosphate protein. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.",384,1.0,-0.04158681,-0.15114255,-0.070443064,-0.09811957,0.020694561,0.044626694,-0.033756223,-0.013170116,0.06407202,0.0045095496,0.041626796,-0.03838614,-0.024713168,0.14886017,0.0077512786,0.019103482,-0.09004568,0.034153767,0.03638881,-0.04056987,0.10045826,0.029823625,-0.009632454,-0.0011674047,0.0015227513,0.07404547,0.0921477,0.017938642,-0.025604315,-0.03459033,-0.026531467,-0.025855536,0.03793911,-0.0805963,0.121030815,0.09944143,-0.06796305,-0.033727296,0.10063139,0.011710386,0.042084105,-0.035615988,0.028080666,-0.0009814948,-0.05430996,0.053733215,0.07759729,0.06119788,0.10639102,-0.058748458,-0.089872815,-0.016263379,-0.016677544,0.01582023,0.007194852,0.00242535,0.019333594,0.020395081,-0.037646435,-0.017539186,-0.028133864,-0.008809601,0.08825103,0.017967558,0.027335139,-0.047004517,-0.025849031,-0.0782743,-0.030658575,-0.024698097,-0.037171967,-0.03690496,0.10086026,0.007095175,-0.020458084,0.010867639,-0.015641619,-0.048418842,-0.039010815,-0.044344116,-0.0014106075,-0.06352063,0.021475073,0.12397743,0.032401446,-0.06998416,-0.017724505,-0.026899882,-0.025302276,0.028442843,0.013646341,-0.006258985,0.03042992,-0.027644997,-0.006102012,-0.008399986,-0.019422356,-0.03869551,0.019821873,-0.032330453,-0.06710959,0.019758929,0.011290819,-0.030371556,-0.040962666,0.0074522006,-0.018925099,0.085710354,-0.015231313,0.032726407,-0.031305637,0.036263585,0.013053642,-0.0032824718,-0.040687967,0.07429172,0.07868418,-0.035390023,-0.08884654,0.036462504,-0.011082984,-0.088139296,0.04780629,0.07509745,-0.08779453,0.045144036,-0.0725354,1.1587846e-33,0.059140358,0.015361873,0.0031917905,-0.05362523,0.010997531,-0.016456101,-0.05281618,-0.011050757,-0.0018165068,-0.06737878,0.005567873,-0.059482582,0.074865915,0.04733367,-0.07144159,-0.014070872,-0.10879237,0.02429115,0.03365972,0.026424881,0.096763924,0.05080375,0.014917768,0.028669618,0.025147572,0.0096700005,-0.010050002,0.019976525,0.015843904,-0.017418172,0.023833785,-0.11506807,-0.11176054,-0.028209219,0.08484614,-0.0434895,-0.06530385,-0.07519858,-0.02627791,0.043217167,-0.07668145,-0.045085352,-0.010465819,-0.006832346,0.013642757,-0.03297057,-0.03651514,0.08080403,-0.026443541,0.03376586,0.1100627,-0.053968992,0.057621382,-0.03675344,-0.066086344,-0.033774294,-0.012355871,-0.022380654,0.003928856,0.0036835128,0.051169522,0.008775344,-0.033439536,-0.010566946,-0.005099917,-0.004033871,0.02450137,-0.045995574,0.07913352,0.07699352,-0.05313789,0.004129091,0.05547744,0.027953207,-0.011690486,-0.032546457,-0.09229441,0.012665636,0.05661385,-0.0027726274,0.0029800546,-0.07539171,0.027439725,-0.018208157,-0.0537199,0.008762146,0.00287144,-0.0845787,-0.029091956,-0.0042842915,0.100238025,-0.11067702,-0.03528877,0.07293116,-0.027266836,-2.3651828e-33,0.076368675,-0.1031623,0.07648796,-0.041767355,-0.0657686,0.01842214,0.04419325,0.04280674,0.025134705,-0.012745898,0.04951285,-0.015572339,-0.007878883,-0.034655377,0.013901417,0.066709645,0.017703034,0.0044325646,0.023177566,0.012109987,0.050505154,0.012308228,0.018352237,0.08002944,0.03633237,0.06652714,-0.016877417,0.051618703,-0.02607453,0.06091094,-0.03050998,0.037647013,-0.013246449,-0.085095905,-0.040380083,0.033881143,-0.09780641,-0.0396193,0.015780287,-0.03548736,0.07750339,0.02981436,0.021242924,0.03439136,-0.021268254,0.09164377,-0.023618395,0.01400126,-0.015870128,-0.06023135,-0.00869666,0.013115598,0.044478524,-0.020673743,0.021159178,0.008756709,-0.05027637,0.02399344,0.018627327,0.011660694,-0.03275324,-0.12420493,0.053847544,0.09446406,0.008873237,0.06334868,0.009299816,0.014132585,0.10129811,0.03983364,0.019846676,0.034053702,0.07223475,0.10665091,-0.048291024,-0.028581455,-0.06681463,-0.011073391,0.031794596,0.0048462474,0.020473996,-0.0067196805,-0.04958429,-0.050931986,0.019463956,-0.045779247,0.06818443,0.09013693,-0.0046759546,0.012825885,0.0026836356,0.041573253,-0.014587876,0.0050375466,0.08679713,-3.3920614e-08,0.07879573,-0.067446135,0.07559509,-0.022787558,0.017584613,-0.0006301475,0.013726166,0.021897707,0.07265232,-0.06740836,0.010263909,0.02229877,0.015826782,-0.01800019,0.033085294,0.015815055,-0.060244504,-0.04197986,-0.0010237631,-0.054639127,-0.07729392,0.014407619,-0.11015001,0.043370415,0.05885721,0.014315753,-0.019740017,0.022256432,-0.02966071,-0.028352326,0.017237516,-0.02831721,-0.063049935,-0.050358415,-0.05638452,0.07531988,-0.08041019,-0.059267126,-0.0056605507,0.016313458,0.0039438857,0.027665285,-0.05992364,-0.018704182,0.03696409,0.0760626,-0.07573457,0.034741163,-0.042787485,-0.050896604,0.09992736,-0.027381992,-0.051456913,-0.016828272,-0.14671311,0.04050224,-0.014035836,-0.06750101,-0.039241508,-0.040677294,-0.025114207,0.0004323462,0.14382938,-0.043399476 +4.1.1.28,"A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.",384,0.99999994,-0.036230695,-0.10673042,-0.05301255,-0.09114446,0.09633943,0.10044732,0.022231849,-0.0008874434,0.0910069,0.041446626,0.046231236,0.015451495,-0.09742338,0.111759,-0.004042742,0.079440035,-0.050193828,-0.02288196,0.011566232,-0.06657492,0.08031883,0.06522264,-0.0074311486,-0.01324115,-0.005006659,0.020351227,0.04059866,0.017075384,0.00068858796,-0.020821413,-0.04755214,-0.047636718,-0.03908892,-0.042048242,0.02254195,0.086355016,-0.12146762,-0.025582176,0.032792784,-0.011113636,0.06731243,-0.062806845,-0.038768336,-0.05775841,-0.08267883,-0.017673038,0.049980324,0.03950807,0.040361322,-0.0055057965,-0.06261417,-0.04581554,-0.013549007,-0.035328392,-0.06317346,0.06018214,-0.00093234784,0.036384944,-0.04002043,0.016224371,-0.024393924,0.04233778,0.040397394,0.020894045,0.04255502,-0.048164736,-0.015127404,-0.030962477,0.0035482242,-0.065107115,-0.013181937,-0.07169024,0.05563304,0.01128598,0.012958147,0.0053177476,-0.040410098,0.0051482636,-0.001923505,-0.044741526,0.014916616,0.0032590348,-0.022338692,0.09581786,0.055234507,-0.0023283178,-0.019084286,0.057875253,0.027632006,-0.057346426,0.05375733,-0.041181423,-0.03724385,0.020862242,0.0018738834,0.0077043143,0.009025512,-0.061017685,-0.043059938,-0.026223406,-0.005690557,0.014867572,-0.021699663,-0.07796909,-0.09046449,0.02462904,-0.02922324,0.03217684,0.004250407,-0.06950524,-0.047812045,0.037102778,0.066390626,0.0015304494,-0.004572537,0.008924605,0.051459327,-0.033875357,-0.047676224,0.011132394,0.0059925923,-0.028151369,0.037691478,0.13076161,-0.026760258,0.0501385,-0.10888433,4.3066293e-35,0.10697828,0.036533408,0.033575293,0.0011526734,0.00390996,0.009159528,-0.042005856,0.00029268122,-0.018734317,-0.007769424,-0.037441973,-0.07587011,0.048348136,0.0047063804,-0.045961615,0.019412769,-0.07959031,0.032510772,0.04485613,0.0009650334,0.0037566538,0.09903642,-0.020922657,0.06500315,-0.008910798,0.08709694,-0.007571164,-0.01874727,-0.010991002,-0.010349546,-0.006730144,-0.07847187,-0.13390197,-0.001301665,0.05363877,-0.044656113,-0.046116907,-0.06333782,-0.020731447,-0.008291809,-0.0334809,-0.01432481,-0.040667992,0.03113093,0.001008556,-0.05888986,-0.0222825,0.0667313,0.0061554248,0.010121157,0.101190604,-0.11170371,0.06722133,-0.030786337,-0.12768562,-0.0005637723,-0.04523457,-0.009634778,0.040013283,0.046852473,0.039767012,-0.03769175,-0.051038623,0.021200346,0.00940659,-0.030657701,0.009759823,-0.075075515,0.047547016,0.0719812,-0.018379698,-0.0002611147,0.09946829,0.021730866,0.022640055,-0.0472386,-0.06270208,-0.011510949,0.016281145,0.06777602,0.03158065,-0.11615046,0.0077744136,-0.05406698,-0.07371371,-0.041028865,0.03862368,-0.11400764,0.011919798,-0.04587868,0.041486725,-0.09723675,-0.028276516,0.05894637,0.011700846,-2.2694733e-33,0.078357145,-0.109997556,0.06526401,-0.043273672,-0.033074185,-0.0137173915,0.06877061,-0.020526825,0.017276388,0.00504814,0.06515569,-0.06652302,0.02104598,-0.054468043,0.02092529,0.022522181,-0.023437385,0.025713246,0.058504783,-0.003151006,-0.033562418,0.0023711305,0.057257943,0.056987002,0.08572948,0.08129088,-0.038288508,0.047264893,-0.020406293,0.018227383,0.004813084,0.019247003,-0.009578939,-0.061123252,-0.022694407,0.039294478,-0.08435328,-0.016785245,0.048454974,-0.0011419668,0.057592686,0.021949954,0.107089244,0.014674524,-0.011098474,0.050575208,-0.06940339,-0.030716004,-0.047560737,-0.108564265,0.020568127,0.06098313,0.017177997,-0.020652603,0.036438767,0.08228212,-0.058952328,0.0055773044,-0.0035456766,0.032783974,-0.033984568,-0.08666977,-0.0027923265,0.11556611,-0.020051625,0.055676024,0.008615402,-0.0050031035,0.08438109,0.04396065,0.085792206,0.027169961,0.09106493,0.12941152,-0.06785211,-0.064064726,-0.040936332,-0.01665925,0.039764564,-0.045324344,0.013432598,-0.04239581,-0.03293737,-0.062122423,0.014355341,-0.06467369,0.024890576,0.09989113,0.026740154,-0.0119113065,0.004484439,0.021987155,-0.016890174,0.046139184,0.10121003,-3.5485712e-08,0.06274856,-0.066396326,0.046071805,-0.05330125,-0.015582867,-0.039005775,0.054099753,-0.0010113928,0.047698934,-0.03805967,0.016379477,0.0023618417,-0.030224392,-0.02071855,0.050517425,0.046067085,-0.03893965,0.038358957,-0.009051852,-0.03874341,-0.033351142,0.020122297,-0.11181846,0.008053814,0.04428633,-0.034445886,-0.02212389,0.08206225,0.040891536,-0.008001606,0.001854761,-0.029283546,0.009770116,-0.0455658,-0.031195013,0.14295611,-0.0821975,-0.053292334,-0.021643145,-0.0037242987,-0.02119886,-0.0059297564,-0.013133006,-0.04039364,0.0037530963,0.035489447,-0.042531982,-0.0044552726,0.006683672,0.0014467735,0.05996185,-0.0047077304,-0.05647872,-0.036100466,-0.14162746,0.026015261,0.0132570965,-0.019626258,0.024646578,-0.11030436,-0.0053018047,0.049354274,0.13802321,-0.030578515 +4.1.1.29,A pyridoxal-phosphate protein. Also acts on L-cysteate. The 1992 edition of the Enzyme List erroneously gave the name sulfoalanine decarboxylase to this enzyme.,384,1.0,-0.05262807,-0.05531415,-0.07872031,-0.10246733,-0.04579786,0.012957269,-0.05788769,0.05058666,0.03722271,-0.01869599,0.032200616,0.05703765,-0.06971408,0.08415988,-0.084947996,0.039369717,-0.05351457,0.019563401,0.033812497,-0.07448415,0.10516021,0.058166683,-0.03057568,-0.022179516,0.037465665,0.085801475,-0.039195742,0.041530732,-0.030121272,-0.035296354,0.016526297,0.038222782,0.006513904,-0.011897047,0.054757394,0.06667909,-0.1302607,-0.036507636,0.06813516,0.00531095,0.03833649,-0.043437056,-0.06142842,0.030846605,-0.056765717,-0.023622965,-0.027394114,0.04400185,0.024171494,-0.04267927,-0.049220655,-0.0131027335,-0.021617778,0.039528165,-0.06122928,-0.007925301,0.010486751,0.057163566,-0.05116087,-0.04559644,-0.068533614,0.07549435,-0.010530796,-0.0011828493,0.04606271,0.009728659,0.0033859562,-0.0611996,0.015974961,-0.006840126,-0.077499524,-0.05740261,0.056325562,0.026474323,-0.042798858,0.05907162,-0.033390515,0.012291862,-0.049788546,-0.031479746,0.0817181,0.0029191943,-0.009945975,0.04088625,0.055359658,-0.040805414,-0.023930117,0.030471982,0.04763018,-0.0015213395,0.05287372,-0.014654363,0.0373336,0.062317513,-0.014391539,0.01578598,-0.00077870005,0.010178841,-0.037706196,-0.047018398,0.028504388,-0.0019589928,-0.07298652,-0.04175907,-0.042932358,-0.00030950402,-0.029744385,-0.002139891,-0.0269285,-0.009419198,-0.1226231,0.022853417,0.013934457,0.0025303296,0.0021329348,0.046763357,0.055303656,0.04081216,-0.027142296,-0.04607373,0.022660194,-0.034372356,-0.013523374,0.0276573,-0.023366887,0.06365529,-0.19836457,-1.3146604e-34,0.07509596,0.05618266,0.10614121,0.03494086,0.005973734,-0.02531932,-0.039809857,0.036030445,-0.034191355,-0.0123801315,-0.021250239,-0.03994521,0.044480115,-0.045915145,-0.08692753,-0.01490388,-0.04578304,0.053595662,0.04184213,-0.03482536,0.03981225,0.05584135,-0.048600223,-0.01577567,-0.04501574,0.08487858,-0.01773458,0.019110443,0.0029700424,-0.0040728934,0.0040686587,-0.15484592,-0.046273824,-0.006624273,0.09886607,-0.0408186,-0.010834212,-0.11899496,-0.011287489,0.036647215,-0.017353741,-0.066914916,0.023995955,-0.013350915,0.03462107,-0.074054085,-0.092560016,0.031798355,0.016056959,0.026997045,0.08235822,-0.057707254,0.03205534,-0.01744737,-0.090380006,0.041476257,-0.052964717,0.021379067,0.036909074,0.017944198,0.05787399,-0.004184002,-0.04791277,-0.055062782,0.022162389,-0.017169856,-0.06989561,-0.05519452,-0.044005685,0.13146947,-0.068783745,-0.044392303,0.069406055,0.0405504,0.10333646,-0.0070420303,-0.0631544,0.05538574,0.008559854,0.025311327,-0.0113010695,-0.07847144,-0.038778413,-0.0546885,-0.06579558,-0.037912544,0.03326502,-0.032641377,-0.04184529,0.043338027,-0.016453048,-0.08701098,-0.04763506,0.080426134,0.035261117,-2.4131819e-33,0.06066272,-0.06329847,0.07138059,-0.04560602,-0.0055333017,-0.021637341,0.060422543,-0.022252291,0.0850528,0.01947991,0.050653484,-0.004553079,0.030540744,-0.05568166,0.0016172612,0.07797994,0.038121138,-0.014584379,-0.0089974925,0.046449848,-0.061652087,0.08715724,-0.0014750873,0.0613071,0.037641115,0.019339396,0.12029587,0.029377278,0.048988372,0.005774951,-0.018634096,0.07651895,-0.01715823,-0.08724017,-0.0938673,0.026581785,-0.06723325,-0.05932539,-0.007852488,-0.022871114,-0.03200445,0.042363185,0.027841737,0.07580619,0.043140195,-0.012286295,-0.035380658,-0.0014681468,0.06051451,-0.028170247,0.023958102,0.046896063,-0.0031024965,0.013751697,0.08137146,0.06942344,-0.042748637,-0.014141301,0.021392968,0.03779851,0.023027344,-0.021133501,-0.063363865,-0.005528542,0.036877565,0.040454037,-0.0061408184,-0.024480587,0.10732154,-0.026661307,0.106595,0.033105664,-0.016571913,0.06235016,-0.08159638,-0.044471223,-0.081646666,0.039345242,-0.0035557891,-0.016930057,-0.0051592705,-0.00800531,0.014150344,-0.055540983,0.029475987,-0.11354771,0.018480204,0.14675885,-0.014880768,-0.020543877,0.021735568,-0.052463308,-0.017224917,0.106753044,0.045903694,-3.0206863e-08,0.047642484,-0.02794947,0.0021475267,-0.03555051,-0.0079635745,0.016049787,0.05979745,-0.016555548,0.038769785,-0.00069691555,0.010632374,0.011477346,0.015632464,0.051137637,0.07212634,0.06485159,-0.06360508,0.056143038,0.01975326,0.03898452,-0.0012946816,-0.009338654,-0.10369495,0.0392707,0.055711385,-0.03279656,0.03343847,0.038539175,-0.012720151,0.00110522,0.03133362,0.016894586,0.057427876,-0.043170255,-0.052029785,0.055058837,-0.036376357,-0.053382274,0.022485135,0.012453953,-0.011928669,-0.016084876,-0.01863482,0.015246721,-0.02913186,0.060420852,-0.021000238,0.022374008,-0.030747255,-0.0019146766,0.0984726,0.01591815,-0.057845738,-0.06620982,-0.044912048,0.016352061,0.014794045,-0.06328845,0.037265632,-0.12169893,0.0046382453,-0.04830906,0.17490332,-0.039282404 +4.1.1.31,"This enzyme replenishes oxaloacetate in the tricarboxylic acid cycle when operating in the reverse direction. The reaction proceeds in two steps: formation of carboxyphosphate and the enolate form of pyruvate, followed by carboxylation of the enolate and release of phosphate.",384,1.0,-0.019493125,-0.008042217,-0.049064297,0.021174878,0.007831728,0.035950746,-0.087726645,-0.047740642,-0.02147435,-0.019731013,0.049860153,0.010809154,-0.05968643,-0.047113378,-0.046857357,0.034975454,-0.03409247,0.023536095,0.037151843,-0.053105354,0.050937336,-0.0075851064,-0.012752273,0.013905867,0.014609996,0.01630701,0.08849019,0.015120743,-0.033685885,-0.08701131,-0.043995652,-0.009754052,-0.0139352465,-0.048480563,-0.033468965,0.15413135,-0.07238854,-0.057823624,0.033675928,0.0013485195,0.032862958,-0.030124664,-0.057376515,-0.012437578,-0.009795519,-0.025456904,-0.010403418,0.012880005,0.0012157781,0.021517007,-0.0044677355,-0.016648326,-0.032313846,0.0072553027,-0.055657983,0.03367377,0.04278277,0.06801512,-0.05137747,0.007495095,0.07538782,-0.012235459,-0.045316394,0.012872014,0.038054544,-0.079553604,0.07948506,-0.060643993,-0.009947968,-0.05580156,-0.036625523,-0.038274765,0.014618846,-0.06522904,-0.012143451,-0.015368006,-0.04302668,-0.031736262,0.05674627,0.048535075,0.080639414,-0.0048682746,-0.032106794,0.044276338,0.03337283,-0.04249771,-0.04918561,0.010642385,0.042106032,0.04983821,0.020376112,-0.008770024,-0.01905552,0.010956531,-0.045393635,-0.012295006,0.009256308,0.036863025,0.0093488945,-0.03594104,0.016774276,0.07642584,-0.046105906,-0.12797068,-0.036430143,0.047513574,-0.028665444,0.04518657,0.04092956,0.06716888,-0.03506097,0.042347226,0.09367485,0.048377827,-0.04953605,0.16238256,-0.052863784,-0.015698507,-0.07591446,0.028865756,0.05475343,-0.061110836,0.012669403,0.0266649,-0.061996408,-0.011601401,-0.04560439,3.9392785e-33,0.0423382,0.023625763,-0.025277665,0.026670424,0.007528828,0.022620715,-0.08095214,0.022428764,-0.0780311,-0.032234598,-0.007409372,-0.032985788,0.041933797,0.0075443094,-0.13048647,-0.07080423,-0.0766983,0.041211836,0.05279749,0.010670217,-0.0131549565,0.07179676,-0.08160852,0.038336053,-0.035241988,0.11230934,-0.0031761627,0.041509777,0.0061611915,-0.0068361415,0.08156162,-0.0701374,-0.118964925,-0.015813382,0.07573041,-0.03730633,0.009005714,-0.03741314,-0.0046350625,0.09423594,0.012827191,-0.005926875,-0.010026448,-0.03922746,0.019779922,-0.08849702,0.034589007,0.14942054,0.039716333,0.032671656,0.0682963,-0.0068472708,0.035588518,-0.014754072,-0.05595753,0.033067204,-0.06729652,-0.03409546,0.048456702,0.019150224,0.10377557,0.007481757,0.006672986,0.0077008,-0.052717943,-0.0027730206,-0.112236544,-0.096468,-0.040016785,0.098611295,-0.049640805,-0.021072023,0.0124214515,0.045311768,-0.0033072683,-0.026837993,-0.045813803,0.055464435,0.023876293,-0.055488493,0.018280441,-0.010552167,0.012676074,-0.014874204,-0.017998418,-0.022697298,-0.029487168,-0.054988403,-0.03541132,0.027070682,0.0482956,-0.044593245,0.0057293456,0.024000369,0.08926149,-5.2348547e-33,0.14095344,-0.05888543,-0.011065451,-0.09148746,-0.031900443,0.040535986,0.050206162,-0.021235146,0.014097904,0.019519502,0.008350556,-0.03244338,0.047511853,0.0027081503,0.053921778,0.043722685,0.09425584,0.03925207,-0.041018594,-0.048540663,0.023871081,0.06708774,0.006024987,0.039935347,0.0030531536,0.005299706,-0.016202675,0.06942193,0.06272742,0.08074224,-0.011848527,-0.06819154,-0.022999834,0.017252073,-0.05392497,0.13076246,-0.07174686,-0.030306837,0.0070149447,0.062829405,-0.044330906,0.016048856,-0.007576608,0.07001049,0.055965334,0.0015657025,-0.08995264,0.021115819,0.016867328,-0.075371616,0.06816101,0.068325445,-0.053883936,-0.012724129,0.04795967,0.097373314,-0.030632634,-0.060306296,-0.02419916,-0.040980227,-0.0820211,-0.04430743,0.05387138,-0.07023321,-0.029842649,0.039114147,0.01450575,0.009488272,0.09922799,-0.010660295,0.07419665,0.09195174,-0.011955307,0.0013088781,0.0030013877,0.008358083,-0.056488626,-0.059546355,-0.0020311712,-0.04384656,-0.056782242,-0.02387732,0.018689916,-0.06340518,-0.04188068,-0.1300887,-0.03360248,0.07479656,-0.029382035,0.009266321,-0.014628235,-0.05115934,-0.024347097,0.06109298,0.11287954,-3.4137205e-08,-0.015627887,-0.079050645,0.086189635,0.03749987,0.007632342,0.005692987,0.09048233,0.022163665,0.008657937,-0.107890844,-0.017869905,0.05319743,0.023130827,0.05567929,0.07062284,0.052523997,-0.021214949,0.08378951,-0.060379557,-0.0069882446,-0.038661454,-0.047196366,-0.055721432,0.042474594,-0.0092799505,0.002194385,0.06869271,0.035874244,-0.04343174,-0.019574044,-0.022650871,0.040204737,-0.010317501,-0.06084449,-0.108547226,0.028721385,-0.01968457,0.06912679,0.014387375,-0.012645831,-0.0064362525,-0.022563377,-0.07816632,0.033046342,-0.012188982,0.0029312323,-0.012656224,0.00824461,-0.01191647,0.007984687,0.07144619,-0.012232238,-0.046052422,0.026386581,0.0094259875,0.006677152,-0.011787797,-0.06857592,-0.0009381968,-0.0018454257,-0.03394783,0.08638549,0.15955874,-0.09549963 +4.1.1.32,ITP can act as phosphate donor.,384,1.0,-0.116802804,0.030391287,0.06613476,-0.08305841,0.04179846,-0.0055729123,0.06217396,0.05612103,-0.06401151,0.07074985,0.013948998,0.059864435,-0.05397489,0.09128445,-0.04643835,-0.02602615,0.05597351,-0.023358697,0.04493223,0.004130218,0.05099858,0.01110404,-0.01743244,-0.062168054,0.06027721,0.0966001,-0.023084044,-0.018503832,-0.011417121,-0.022400392,-0.07817713,0.0018771283,-0.03383659,-0.046999574,-0.014845804,0.083783306,-0.008056825,0.019968376,-0.0041249995,-0.026038026,0.08352373,-0.057977937,-0.015231565,-0.02154858,-0.023762105,0.016371442,-0.013580946,0.011866059,-0.02620409,-0.042438358,-0.021009205,0.036129497,0.015611501,-0.053481016,-0.06837737,-0.029209249,0.017297734,0.009757646,-0.07366915,-0.026156502,-0.026479753,-0.038614597,0.01764987,0.05472726,0.16194016,0.0043356977,0.05346966,-0.0131778335,-0.02750567,-0.0018096928,-0.033103753,-0.011910016,0.032837987,0.073337205,0.051728196,0.076724894,0.01080841,0.021727085,0.038684275,0.08619405,-0.0052915253,0.050610483,0.018389313,0.019869823,0.016319687,0.027088694,-0.069473356,0.05445326,-0.06622836,0.011106534,-0.019962994,0.0044181375,0.027812568,0.024481291,-0.027417636,0.028551588,-0.057240006,-0.027269319,-0.028567342,-0.05703894,-0.016062919,0.049033023,-0.024358958,-0.081737466,-0.026881294,-0.03218642,-0.046818532,-0.07582202,0.09600682,0.038606904,-0.023093712,0.031214967,0.02211605,0.012808297,0.022073543,0.08930803,-0.09639098,-0.017656554,-0.016204923,0.004719268,-0.0345145,-0.11776054,-0.030095909,0.074476756,-0.087168366,-0.032521676,-0.047306065,-2.6689037e-33,0.033868328,0.04713822,0.06503484,-0.005513993,-0.044650175,0.019173408,-0.004415694,-0.010007025,-0.10326084,-0.06444335,-0.06804118,-0.08450224,0.028639412,-0.011684631,-0.10582785,-0.041625015,-0.08063091,0.046270076,0.07486081,-0.035973366,0.06651795,0.054109126,-0.05399743,0.034256727,0.09046639,0.02306169,-0.05132555,-0.017393222,0.028180778,-0.0016703213,0.068168774,-0.055693746,-0.09304055,0.019521398,-0.020659605,-0.04237448,-0.015376736,-0.051620305,0.014526906,-0.004370556,0.017470073,0.021609379,0.05622143,0.09034948,0.05067779,-0.016678445,-0.0026068583,-0.05642934,-0.10462544,-0.039665986,0.011140802,-0.025224471,0.015071763,-0.065265104,-0.031527504,0.03361388,0.0273433,-0.017207248,0.05091621,0.046152085,0.070816025,0.022591928,-0.0036672289,0.050000723,0.0033022782,0.022449305,0.017524488,-0.098510265,-0.001192609,0.099101625,0.0016446138,-0.029119084,-0.01713505,0.038584393,-0.04740431,-0.031232735,0.023263408,0.06348621,0.020496283,0.05525451,0.006541829,-0.0840638,-0.016304739,-0.03599734,-0.015222312,-0.01260135,0.001921213,-0.09864254,0.025503416,-0.02612259,0.11980356,-0.06289097,-0.055803288,-0.038497873,0.024690036,3.7876083e-34,0.038121734,-0.080055535,-0.011243628,0.05276432,-0.0039417353,-0.006912248,0.12631911,-0.027881604,0.14337413,0.093596995,0.0391427,-0.055365905,0.07551702,-0.09532736,0.013000271,0.047994472,0.017869903,0.0061227954,0.012595328,0.036110777,-0.020168228,0.05186402,0.087707765,0.06571209,-0.05187781,0.03712647,-0.06058308,-0.026220802,0.07096815,0.024335342,0.042587623,0.030842332,-0.13950959,-0.075630166,-0.0489942,-0.032800805,-0.07163296,-0.03821896,0.009291807,-0.04678935,0.05603085,-0.017708918,0.047752224,0.050538845,-0.050650958,-0.012953129,0.039340023,0.086710304,0.02893363,-0.023436416,0.042820252,0.08805537,-0.01600193,0.05250617,0.023211312,0.067603536,0.1088681,-0.0040011825,-0.0646541,-0.06204778,-0.0068321927,-0.02340755,0.05631953,-0.013161793,0.0050705527,0.07641257,0.03910037,-0.049996044,0.006238111,0.0032871927,0.0361625,-0.056127813,0.017740633,-0.0011231179,0.02415293,0.011789275,-0.062899314,0.05704437,-0.007477216,-0.0023480994,-0.060876977,0.022693532,0.008182837,-0.034195036,0.116940446,-0.10679728,0.06901041,0.041089844,-0.042252406,0.006001255,-0.08280956,0.010855659,-0.014214372,0.013879482,0.021871233,-1.5403907e-08,0.025433054,-0.015280642,0.08831737,-0.009064606,-0.06015346,-0.07507723,0.046891734,0.02572993,0.076621436,-0.032421105,-0.056536537,0.034027126,0.02339932,0.00015010689,0.11901567,-0.046592202,0.034361452,-0.008149241,-0.061247386,-0.09926044,-0.041978344,-0.06376868,-0.004339505,0.0035535211,0.021291094,0.10397224,0.009067143,-0.03692977,0.055613063,-0.062976725,-0.03243345,-0.056728713,-0.079418816,0.004967061,-0.04405996,0.07097038,0.022176065,-0.055693798,0.0034289882,0.012598297,-0.072708264,-0.036361698,-0.04529859,0.04591953,-0.04983654,0.076378174,0.018777294,0.0087712,-0.05808343,-0.03274552,0.005069826,-0.030548083,-0.042093474,-0.06660482,-0.01800935,0.022338439,0.06806664,-0.014700692,0.076132774,-0.011783625,-0.004200441,-0.02454815,0.099335924,-0.029666532 +4.1.1.35,Requires NAD+.,384,1.0,-0.06878425,0.022418711,-0.053952727,-0.016134635,-0.04897264,0.06289609,-0.030143915,0.010669343,-0.003183227,0.03938317,-0.02209948,-0.014993911,-0.058369208,0.08770232,0.005057102,0.018540792,-0.004241495,0.026848016,0.021070817,0.025145229,0.051068284,0.003422877,0.072723284,-0.01820859,0.06801252,-0.013825288,-0.049557935,0.027358204,0.089087516,-0.050625946,-0.026951827,0.042057585,0.003714755,-0.041774,-0.07487685,0.008750964,-0.06711072,-0.0015589169,-0.026578454,0.033997674,0.0069180927,-0.060703434,-0.03088875,0.0866388,-0.01877226,-0.082746536,0.016040761,0.043075323,0.05287882,0.013214744,-0.08002864,0.011352289,-0.028130516,0.013129261,0.051064674,-0.040237524,0.0043854923,-0.020197976,-0.019096883,-0.031847764,-0.038290802,-0.07046345,-0.08907335,0.0492619,0.0845278,-0.0030918056,0.033161044,-0.0016798137,-0.041360088,0.04743689,-0.08996856,0.03448865,0.008086315,0.04895464,0.0033891012,0.07331984,-0.083484225,-0.059768118,0.12877707,0.019068506,-0.036896434,0.022171225,-0.090521745,0.0069394433,0.14800002,0.05467556,-0.026208809,-0.025799705,-0.048744645,-0.0059925215,0.0026595385,-0.019939635,-0.009184698,0.060988102,-0.07809198,0.0057957186,0.02040638,-0.013456087,-0.054213773,0.062357537,-0.018138552,0.08147702,-0.042604342,0.017021615,-0.057537433,-0.02113984,0.02836716,0.07532199,-0.060083464,0.02279571,0.0018487689,0.008646811,0.03698565,-0.059036586,-0.06920008,0.09812879,-0.020373061,-0.006502994,-0.022361793,-0.056976307,-0.03316445,-0.0074004014,-0.016645474,0.0037570226,0.0081338165,-0.050095916,-0.0056487187,-4.6826648e-33,0.09235815,0.05338163,0.011236184,0.10115843,0.0053777806,0.060964406,-0.07489847,-0.0071162726,-0.060803924,-0.07005021,-0.06295462,-0.077826686,0.012041837,-0.018896807,0.10158911,0.052189797,0.019164147,-0.050406016,-0.034262966,-0.047203273,0.04309886,0.024661193,-0.02269407,0.028002527,-0.0012545489,0.05890502,0.034546826,0.0029719756,-0.019439071,0.027478365,0.04855415,-0.091883585,-0.10473347,0.013965188,0.030152159,0.054002997,-0.072750494,-0.042713985,0.03639799,0.04479241,-0.07412687,0.07226459,-0.02366356,-0.037748724,0.037109118,-0.079526655,0.074475884,0.10534082,-0.010932426,0.07541058,0.012110492,-0.0028663273,0.05779693,-0.016673632,-0.016755233,0.075922236,0.047118027,0.023571553,-0.00023787416,0.13184592,0.025702558,-0.010675333,0.008317998,0.0952034,-0.13331889,0.011129972,-0.1063271,-0.063091435,0.04861221,0.02580615,-0.00073961064,0.0142752025,0.022426242,0.008276227,0.030087216,-0.03927804,0.0493954,-0.04884962,0.039260026,-0.013528945,-0.047771476,-0.035876106,-0.036817458,-0.003507331,-0.0096555045,0.008722018,0.0291098,-0.03092306,0.004282515,0.05048849,0.015952094,-0.050346527,0.0039171963,-0.07538181,0.0059954314,3.5683005e-33,0.00866626,0.023690503,0.03318855,-0.03830764,0.056684222,0.03794229,0.04440472,-0.15212803,-0.02121104,-0.033166327,0.027741728,0.06639345,0.016479481,-0.027978659,0.041975386,0.011642394,-0.04727861,-0.042929877,-0.016661396,0.005573803,0.031086456,0.14377128,0.057882022,-0.013367941,0.016548494,-0.0073285582,-0.059595108,0.072514884,-0.034135524,0.020862656,0.02821628,-0.030110646,-0.14643662,-0.033864122,-0.026493056,-0.0015618297,0.037779097,0.0329752,-0.07400528,0.073723495,0.048474837,-0.014463436,-0.0652607,0.121435285,0.037335522,0.013210648,0.0090542305,-0.063324176,0.059819736,-0.006296046,0.014621462,0.03049263,-0.070291854,0.013424272,0.03866232,-0.0307609,-0.05184867,0.03840256,0.044075005,0.018195717,0.010647509,-0.004967439,-0.0071593733,-0.083262466,0.08556599,-0.0160003,-0.012172486,0.03631846,0.06073557,-0.00946426,0.010774417,0.0719881,0.027298948,-0.043068673,-0.024945745,0.014567179,-0.095189996,0.06947878,-0.0030031013,-0.045961633,-0.10132435,-0.04427107,-0.034111977,-0.049235493,0.06295752,-0.037940934,0.097294465,-0.08145694,-0.03951798,0.033203676,0.0103231,0.065752484,0.03948528,0.0598022,-0.039136365,-1.3636822e-08,0.011917494,1.4096073e-05,-0.008929148,-0.041335754,0.01597744,0.044829488,0.043431498,-0.05939643,0.005649463,0.084154725,0.10219487,0.067879215,0.10947128,0.08929933,0.055047493,-0.042749062,-0.027997252,0.044140235,-0.13267457,-0.0592836,-0.08438197,-0.0096346075,-0.062240858,0.13391991,0.02083735,-0.025069138,0.04183365,0.008890681,0.07415759,0.014711216,0.04590546,0.021397868,0.031297743,-0.031419184,-0.051015496,0.0878698,0.015182229,0.055078547,-0.0017691129,0.03071403,-0.060774803,-0.022852689,-0.034646098,0.04620306,0.007813158,-0.0061408314,-0.030427601,-0.0584266,-0.059588622,-0.05647291,0.051814128,-0.0064982073,0.020516653,-0.029650392,0.0017921664,0.040331192,-0.00051787606,-0.008993585,-0.007561174,-0.049609452,0.09806808,-0.03033586,0.064939894,-0.0472908 +4.1.1.37,Acts on a number of porphyrinogens.,384,1.0,-0.010959585,-0.060089264,0.04195252,0.08477651,0.034690976,0.01424446,0.14543103,-0.010975282,0.023412045,0.010503796,0.033001047,-0.029102372,-0.12150354,0.038213797,0.06980692,0.06397647,-0.021822436,0.010344066,0.0069263848,0.017087037,0.062373973,-0.006013771,-0.019192308,-0.039547745,-0.037539817,-0.037067574,0.01375102,-0.03689011,0.021057673,-0.060387958,0.04207142,0.055848744,-0.051002786,0.0051234076,0.04994998,0.016424036,-0.020943284,-0.0776517,0.08649127,0.06228144,0.04863548,-0.05200429,-0.051760137,0.040057685,-0.033664238,-0.01670505,-0.010065152,0.024733556,-0.019501725,-0.014579024,0.028273495,-0.04767269,-0.05917952,0.025412114,-0.027489187,-0.057696357,-0.067642435,-0.052921932,0.007927309,-0.091463156,0.04517815,-0.010520215,-0.029147042,0.0044201897,0.04001748,-0.025732461,0.05329072,0.031083977,0.095422305,-0.03353062,0.035663884,0.004950529,-0.043500554,-0.009932372,-0.0072772913,-0.029525938,-0.022279436,-0.055909667,0.033744603,-0.039984275,0.016600061,-0.0037037928,0.011906326,-0.008819223,0.077677265,-0.046818133,-0.0417091,0.009424962,-0.034200463,0.056926314,-0.085056126,0.002206953,0.038421508,0.038705017,-0.055572264,0.048646234,0.050231595,0.025642188,0.006486275,0.05708363,-0.033843234,0.0035922856,-0.067385815,0.06046067,0.019015204,-0.047603082,0.025158133,-0.012427498,-0.01946984,0.033981048,0.012372167,-0.023479607,0.04200482,0.024080843,-0.018790286,0.009506328,0.019022986,0.0592098,-0.025206372,-0.013740114,0.03949738,-0.0021446387,-0.06419836,-0.0028923117,-0.06714661,0.040786248,-0.050925635,-1.8217907e-33,0.123871535,-0.013504722,0.006135897,0.06535738,0.013576028,0.0019351338,-0.049211152,-0.10693497,0.011974537,0.039231773,-0.07594968,-0.019250527,0.013684087,0.047032986,-0.03921364,-0.060940135,-0.05446406,0.079752594,0.06179036,-0.002663098,-0.055329926,0.100844435,-0.10578126,-0.028894577,-0.03590486,0.073405705,-0.069447584,-0.0071808733,-0.053358007,0.0034557632,0.10062754,0.011615711,-0.036598247,0.13493958,0.095367886,-0.048238322,-0.04700955,0.011815203,-0.032149497,-0.08092506,-0.060829014,0.028873786,-0.07836523,-0.06314664,0.055399477,0.021442946,-0.047136992,0.038150985,0.048480727,0.0656077,0.04031642,-0.04246195,-0.0019536808,0.08973697,0.014600581,0.0056078313,0.00058951037,-0.03145333,0.033434715,-0.012447638,0.019164143,0.043550886,0.029758818,0.046385907,0.07075179,0.016020944,-0.056589145,-0.035323396,0.02226428,0.04704539,-0.048321996,0.003894047,-0.04026424,-0.011329362,0.039528076,-0.02380341,0.045932002,-0.020060237,-0.077802874,0.019381855,0.004677137,-0.11527792,0.07521093,-0.016550409,-0.08964184,0.04413993,-0.056774314,-0.054976415,0.06497204,-0.008855604,0.06481773,0.015170773,-0.0084115295,-0.10930817,-0.08081946,4.2364357e-34,-0.0039700293,-0.018379197,-0.011614815,-0.029782271,-0.08321248,0.09147467,-0.09987223,-0.049829267,-0.01423275,0.08274909,0.011683214,0.050871536,-0.017932933,-0.081293724,-0.033040773,0.0097566005,0.061485916,0.069280595,-0.0029058426,-0.00021817954,-0.10099724,-0.012770004,-0.057489816,0.046926506,-0.00025632654,0.05219313,0.045547694,-0.08648221,0.05969396,-0.035719138,-0.014167722,-0.011834363,0.027593551,0.04420862,0.02160924,0.015851108,0.03879819,0.06852929,-0.109337635,-0.05841609,-0.011656059,-0.023422157,0.1333916,0.079459,0.06810455,-0.020435194,-0.007975929,-0.025187045,-0.13571258,0.04720008,-0.0140454965,0.0022065304,-0.022814903,-0.086753584,0.017357422,0.024925781,0.020079311,-0.086143956,0.027882319,-0.0440443,0.05109257,0.00240169,0.010749748,0.00071307365,0.06616278,0.009842488,-0.10221681,0.054374024,0.05958715,0.015210004,0.06024779,-0.0028632998,-0.06332196,-0.03281414,-0.0016499743,-0.027029129,-0.02683084,-0.06420081,0.044666287,-0.04191784,-0.08713564,-0.0064398455,0.04618737,-0.058891226,0.004407244,-0.037493844,-0.042042382,0.029563485,0.07310946,0.052776612,-0.023846487,0.024378821,0.027584342,0.005999421,0.028092131,-1.7465004e-08,0.06876491,0.011782327,-0.0137779815,0.04032998,-0.03786313,0.02918383,0.011925036,0.049887445,0.045909062,0.026000358,0.020505495,0.09987288,0.120420866,-0.011449855,0.09712328,-0.0095914425,-0.01109988,-0.054039072,-0.08886982,0.00030339806,-0.04193744,0.034513168,-0.042619415,0.013542048,0.019997379,-0.0039902227,0.082121804,0.16041754,0.038632266,-0.00514056,0.029021913,0.010755256,-0.061842926,-0.0005966109,-0.060606368,0.019567646,0.0019190147,-0.071555756,0.020651115,-0.03597921,-0.10199347,-0.007880778,-0.03281547,0.07525705,-0.014243589,0.04424038,-0.07225686,-0.058524527,0.04076192,0.06785547,-0.0019663733,0.0406261,-0.023038687,-0.022062918,-0.16472013,0.11726769,-0.018982481,0.02160815,-0.008741997,-0.08617146,0.041433245,0.022990003,0.002624606,-0.010074992 +4.1.1.38,Also catalyses the reaction: phosphoenolpyruvate + phosphate = pyruvate + diphosphate.,384,0.99999994,-0.032960676,0.035984866,-0.046680093,0.010304582,0.043658752,0.033246826,-0.00920507,0.013692277,0.015619093,0.11187324,-0.0021293627,-0.0030810293,-0.05120462,0.02735737,-0.030496225,0.021393832,-0.04883441,0.022738485,0.049364924,-0.01177028,0.13333966,0.007835017,0.00092881307,-0.022986539,0.054193735,0.053202152,0.0809394,-0.037730165,0.04026746,-0.030464226,-0.069445066,-0.01225845,0.033070434,-0.09441373,0.005275807,0.1446446,-0.056064017,-0.051229775,-0.013994455,-0.0036893259,0.057450287,-0.009802906,-0.0024709443,0.011742663,-0.032154873,0.05906034,-0.007323115,0.058937296,0.003203438,-0.029786887,-0.06057001,-0.02117042,-0.08621418,-0.019640146,0.0039958805,0.020201715,-0.073739305,0.03726699,-0.0226355,-0.06508234,-0.07446164,-0.0073383157,-0.027498966,0.022210615,0.09114576,-0.042648546,0.04100393,-0.03420836,-0.018181425,-0.03434768,-0.04148161,0.0122028515,0.075011976,-0.08283837,-0.0009347559,0.035610985,0.03527368,0.01228352,-0.0036258316,0.013439144,0.035546422,0.0012121327,-0.06315619,-0.019157201,-0.0019115632,0.03985151,-0.002525335,-0.021472504,0.010390981,0.024269149,-0.048578314,-0.013342241,0.028953638,-0.018788487,-0.048899937,0.044198636,0.008687135,0.012197456,0.05612573,-0.05179297,-0.006138608,0.102390274,-0.034835342,-0.063813,-0.020123255,0.03542248,-0.033975534,0.06903567,0.03490591,0.039015524,0.009613745,0.03922198,0.05801345,0.006386376,-0.011304363,0.09729855,-0.0047090724,-0.08529635,-0.06739667,0.01196297,0.05685459,-0.070923634,-0.04349231,0.043171335,-0.15631999,0.033011395,-0.0599172,3.580487e-33,0.021368673,0.05723425,0.021002695,-0.060639378,0.020232353,0.022837436,-0.07163259,-0.026041903,-0.029850602,-0.020729745,-0.06452611,-0.10814694,0.09430837,-0.016675074,-0.10041483,-0.04544446,-0.03039296,0.06926916,0.07049659,-0.015134559,0.015314472,0.035990823,-0.014550499,0.05763781,-0.011619422,0.0535671,-0.05006723,0.0037369346,-0.007993783,-0.04157388,0.12145299,-0.07486913,-0.08518641,-0.0136013385,-0.030975722,-0.059139762,-0.05802266,-0.08262203,0.027426096,0.024505945,-0.06045879,-0.044239137,-0.022245565,0.046961263,0.04232314,-0.12164071,-0.030291306,0.06896167,0.075859584,0.07609139,0.033004954,-0.035292026,0.10523918,-0.020345857,-0.05320256,0.016944127,0.0047954973,-0.08033488,0.018023772,0.042307224,0.04530178,0.068106346,0.004662934,-0.017041055,-0.01425417,-0.011482368,-0.0267735,-0.044165242,-0.012430928,0.06310276,-0.049267545,-0.015235055,0.08760321,0.033304777,-0.017758181,-0.026175557,-0.027166942,0.0011417432,-0.03126437,0.008322113,0.057614356,-0.028193114,0.04733941,-0.002442277,-0.04974395,0.03701037,-0.03932152,-0.049367987,-0.019561218,0.08412413,-0.04181792,-0.057690486,-0.028235948,-0.0029572826,0.01614714,-4.1916262e-33,0.12303468,-0.060739134,-0.051598113,-0.10459437,-0.04954271,0.00124237,0.045619145,-0.086805075,-0.0077750087,-0.03050807,-0.006938134,-0.043245822,0.011392835,0.01699697,-0.0052748304,0.05988116,0.05536034,0.09123991,0.027864844,0.023110654,0.007694086,0.12994337,-0.021806315,0.0798592,0.08514743,-0.0053780237,0.025648223,0.06027318,0.00025794146,0.07553059,0.017100457,-0.043220624,-0.08886315,-0.009589317,-0.027741343,0.034532417,-0.034222748,-0.049435593,0.029445129,0.019008089,0.048076853,0.04130425,0.08941694,0.027392099,0.027640857,0.02152031,-0.026711829,6.706812e-05,-0.058487266,-0.028855862,0.02397013,0.08454781,-0.0926268,0.014842748,0.055929452,0.066145524,-0.025395911,-0.001804152,-0.008233128,-0.057422392,-0.030594952,-0.13039951,0.056623638,-0.048451394,0.05278823,0.06134814,0.006580566,0.011396135,0.03196578,0.033618253,0.047059696,0.097022265,-0.031927466,0.00018862811,0.016677259,-0.00062372204,-0.076483876,-0.0072581423,0.036480684,-0.072033495,0.012350701,0.010183652,0.0043358803,-0.11724563,-0.04485495,-0.04139519,-0.015996719,0.07075821,-0.028696453,-0.010638231,-0.03260696,-0.06239732,0.027388573,-0.010176258,0.108585,-2.2844446e-08,0.048660733,-0.018554404,0.041012462,0.0028619457,-0.021791946,-0.0018281245,0.070731446,-0.036750276,-0.0064184675,-0.061676018,-0.036264397,0.021655453,0.10415935,-0.0058558476,0.09406188,0.00031498462,-0.060421817,0.06886622,-0.06382061,-0.030196397,-0.053364486,-0.011003113,-0.100252464,0.092829846,0.07096537,-0.020828504,0.06963792,-0.0069073644,0.0037129866,-0.045335114,0.03465884,0.0004893541,-0.018032463,-0.09792676,0.024067236,0.052059785,-0.009188635,0.016759742,0.029083641,-0.009661597,-0.09414532,-0.035647865,-0.011826792,0.048357636,-0.049270242,0.07557206,0.01643148,-0.003969307,-0.021272369,-0.009696987,0.09072818,-0.04368274,-0.0400325,-0.07171605,-0.05755408,-0.044016905,0.019542439,-0.025509931,0.021476269,-0.010219576,0.061180502,0.06923893,0.17265132,-0.07248736 +4.1.1.39,"Will utilize O2 instead of CO2, forming 3-phospho-D-glycerate and 2-phosphoglycolate.",384,0.99999994,-0.016463185,-0.02887991,-0.07257478,0.0009923105,0.04530525,-0.07106052,-0.013329269,0.022732763,0.0029321373,-0.0047510597,-0.01509699,0.009153717,-0.1118296,0.015734972,0.0066837207,-0.030012919,0.06389824,0.024258746,0.025948929,0.039042313,0.20029445,-0.053113602,-0.0039970553,-0.007617269,0.018712696,0.03515076,0.02046294,-0.0057056,0.050520945,-0.062041968,0.0045943577,-0.005550333,-0.03313516,-0.04457691,-0.006353563,-0.036805805,-0.010973506,-0.014907646,-0.0039786547,0.022524318,0.030029247,-0.0017178329,0.06748736,0.016875735,0.012424698,0.02721336,-0.020090472,0.03152923,0.026150668,-0.052772563,-0.04546212,-0.0726961,-0.18166806,0.0050677205,-0.04857227,0.08142192,-0.08541428,0.041625302,0.05138692,0.011189787,-0.0054151784,0.0017108609,0.061121084,0.06933359,0.10695104,-0.051200766,0.026384402,-0.009655128,-0.05313958,0.03207423,0.009955973,0.06411457,0.015716638,-0.056812767,0.047948167,0.122510016,-0.016065791,-0.014350315,0.06914876,0.006928029,0.032399163,0.06684048,0.047105435,0.05937364,-0.061799455,0.06435908,0.008637009,-0.08343565,-0.041304417,-0.048642058,-0.077926144,0.032770168,0.08305107,0.052869134,-0.11269081,0.06485894,0.078429885,0.034937397,0.029513689,-0.037401073,-0.030115867,0.11103982,-0.003764156,-0.12127955,-0.03974989,0.010310742,0.020144818,0.03769189,0.08921513,0.056987368,-0.039159853,0.01674108,0.03879615,-0.007435563,-0.053473625,0.06850984,0.019229693,-0.032801025,-0.08269901,0.08252257,0.01183044,-0.09001475,-0.03360133,0.005143547,-0.09270964,0.01603969,-0.0028275852,3.973681e-33,0.0014926649,0.036392897,0.06496649,0.04385479,0.008030039,-0.02275729,-0.12097757,-0.1285434,-0.059307795,-0.010099119,-0.058885995,-0.016721178,-0.025768755,0.1227292,-0.0281281,-0.050353274,0.0012685215,0.03750176,0.034593802,0.004897124,0.02768788,0.017715152,-0.044761866,0.044009976,0.07428706,0.03411831,-0.010939347,-0.030962823,-0.0061017787,-0.023777554,0.14019676,-0.015974512,-0.09046166,0.08126221,-0.010772329,-0.033679705,-0.104983166,-0.052284952,0.01424537,-0.011110136,0.02319813,0.010499337,0.047085945,0.018724702,-0.0035150927,-0.08340143,-0.034651384,0.091872044,0.060455516,0.067219295,-0.00621923,0.03284506,-0.011203454,0.09545009,-0.02791691,-0.020443587,0.011319748,-0.083357476,0.05539898,-0.05382802,0.019816857,0.052219257,-0.000385113,0.05493643,-0.04408654,0.044589303,-0.0674923,-0.02383734,0.023373844,0.0013289757,-0.016573792,-0.05373197,0.038000897,0.05342899,-0.019387709,-0.074676804,0.043656323,-0.022233803,0.022456342,-0.005186341,0.05417455,-0.068869665,-0.014912411,-0.086241044,-0.11324456,0.041408036,0.0060300827,-0.008506976,-0.006603286,0.068204045,-0.005634039,-0.053401876,0.020766405,-0.0352429,-0.05023338,-4.0415498e-33,0.058174923,-0.05274813,0.024297573,-0.038974103,0.007832008,-0.009705939,0.0041875904,-0.09441851,0.1000979,-0.009981676,0.06922499,0.025914954,0.036801007,-0.006106774,0.012701645,0.05526054,0.011454571,-0.004811459,0.009297895,0.030162321,0.0006721076,0.040622678,-0.03058116,0.050518055,0.10609991,0.027996438,0.0006276965,-0.07622387,-0.018799983,0.056904744,-0.02594715,0.0022886363,-0.014328282,0.0032574234,-0.061433204,-0.027049923,0.0020673058,-0.08134023,-0.030141199,-0.060008008,-0.022755446,-0.028581744,0.057221603,-0.006928279,0.0057080323,0.081641205,-0.0006493061,-0.006391367,0.024618775,0.10368011,0.028016647,-0.016974162,-0.11733645,0.033453226,0.06317287,0.08296439,0.012847108,-0.019274084,-0.06714963,-0.0601252,0.016715692,-0.042153213,0.020173185,-0.07344653,0.07525402,-0.0021449612,-0.043115098,0.049006972,0.036964774,0.02563483,0.07921947,0.082976595,0.055958603,-0.022498114,0.016482987,-0.0656182,-0.027814433,0.018818224,-0.077375785,-0.029059872,-0.058842674,0.043897886,0.039892968,-0.011273294,0.049051374,-0.10407338,-0.011711779,0.08130322,-0.032440335,0.07259132,-0.07758624,-0.020782854,0.056303702,-0.01576615,0.079562426,-3.3706222e-08,-0.022505578,-0.020722743,0.07306969,-0.010290889,-0.06384419,0.011304264,0.0478194,-0.0075134053,-0.014903804,-0.06826752,-0.03126373,0.05603015,0.07651019,-0.0696374,0.046792477,-0.014715762,-0.042007327,0.018445803,-0.05442927,-0.015277601,-0.06959857,-0.049384467,-0.07088151,0.10137932,0.02417814,0.036830723,0.042145878,0.012788768,-0.089117736,0.043375537,0.0030061088,0.013404495,0.0039034353,-0.030288367,-0.052015096,0.0078331055,-0.05917086,0.009568962,-0.07193597,-0.007649757,-0.043439135,-0.034449514,0.006018194,0.032753516,-0.007274858,-0.030563204,4.556418e-05,0.014996261,-0.020760218,0.015372216,0.032199297,-0.045436066,-0.043469753,-0.031180969,-0.0054552723,-0.015501392,0.022477275,0.049953558,-0.02604476,-0.03609846,0.02367286,0.0010597642,0.09800411,-0.058664396 +4.1.1.41,"The enzyme from Veillonella alcalescens is a biotinyl-protein, requires Na+ and acts as a sodium pump.",384,0.99999994,-0.07274192,-0.02541983,-0.009258132,-0.016077116,-0.00519024,0.0447063,-0.010771963,-0.0035427017,-0.004882813,0.0046907496,0.016579917,-0.10346583,-0.01498993,0.109821394,-0.039418306,-0.016593268,-0.049843803,0.038748756,-0.023824854,-0.056534752,0.1505118,0.080095135,0.020678012,0.03365962,0.034199536,-0.02871553,-0.0051151505,-0.035381906,0.04946385,-0.09793099,-0.06638083,0.0028359946,-0.0043030917,-0.04988175,-0.02508011,0.009989122,-0.070482224,-0.014466957,0.02904085,0.046624813,0.06515419,0.015737992,0.02808811,0.059205767,-0.016021954,-0.07676872,-0.013823558,-0.023554005,0.10014078,0.03157473,-0.096792676,-0.050677758,-0.012696211,-0.00807459,0.023120597,0.007222687,-0.10007021,-0.019210791,-0.015553412,0.018306732,0.082310736,0.016481766,0.008626102,0.0260927,0.05596053,-0.04345289,-0.051684305,0.010514693,0.016987551,-0.052726205,-0.08106509,-0.07378112,0.06453064,0.08513851,0.014355841,0.022413867,-0.015224794,-0.08254203,-0.07546972,0.043545987,0.037076436,-0.050977856,-0.054337535,0.103390634,0.07878647,-0.037898537,0.047042925,-0.0005219102,-0.03063359,0.011334428,0.02093807,0.008134084,-0.023142902,-0.046906225,0.019544547,-0.013789718,-0.07124713,0.03526654,-0.051191412,0.024209818,0.029530589,0.03187436,-0.019918416,-0.02314327,-0.038852327,-0.04459645,0.06897611,0.03636728,0.010636265,0.024419108,0.028603682,0.009520926,-0.008424648,-0.026469612,-0.05903811,0.10904958,0.018942906,-0.12764911,-0.027983677,-0.025583357,-0.011064764,-0.04285963,0.00036638902,0.0035876087,-0.0014341092,0.057219442,-0.087001964,-1.1426005e-33,-0.02618003,0.038618937,-0.04854436,0.017513199,0.002337796,-0.013213024,-0.061062127,-0.024846235,-0.091825195,-0.09890203,-0.034479808,0.0044109295,-0.0068887123,0.06630922,-0.03037852,-0.055059444,0.04123663,-0.06110215,0.075401835,-0.030133346,0.05492338,0.06461695,-0.06572161,0.011249541,-0.0031501432,0.0047342754,-0.013021479,-0.0136526795,0.04219359,0.0046698726,0.043900933,-0.03614283,-0.0987851,0.07552359,0.038253218,0.061094414,0.056095667,-0.054876074,0.05653067,0.023617154,-0.046824366,0.055033583,0.0030442008,0.035742722,0.0076265987,-0.09146414,-0.104902245,0.04979407,0.08931569,0.05565803,0.09949823,-0.025730366,0.003877185,-0.047700956,-0.09925621,0.098379605,-0.070009984,-0.0049098385,-0.03977295,0.05832035,0.022297796,0.0029155603,-0.060672868,0.0099954745,0.004619732,0.052830257,-0.043485712,-0.07814532,0.082966685,0.028475545,-0.08271244,-0.007837499,0.04946258,0.079383194,0.01735495,0.01614387,-0.09276283,0.036791787,0.024098882,-0.009685447,0.04031873,-0.044446975,0.031923674,0.054269843,-0.06481233,-0.003680788,0.008846728,0.08785246,0.054215416,-0.03004269,0.108119175,0.016135301,-0.008332432,-0.0063051456,-0.023415642,7.133905e-34,0.080458626,-0.058787417,0.0060987226,-0.0027125948,-0.012598114,0.02814152,0.088145465,-0.04711723,0.015905015,-0.022500906,0.06778819,0.02597923,0.10046238,-0.04907076,-0.041542172,-0.03320652,-0.017218405,0.000831938,0.028924137,-0.03288267,-0.06910861,0.09876324,-0.0004965534,-0.008880391,0.02301118,0.035395294,-0.036512285,0.09724994,0.010905287,0.0101777455,-0.031142253,0.073559746,-0.06577105,-0.09081715,-0.12737426,0.047457077,-0.03237257,0.023742022,-0.059276134,-0.009275848,0.008559149,-0.008207252,-0.0032468275,0.011973099,0.078370824,0.03587852,0.032881636,-0.036368873,-0.04536195,-0.049255602,0.07981918,0.050326854,0.06173662,-0.017127931,0.014844274,0.07961341,-0.031656448,-0.020659227,0.07168222,-0.035749633,0.059701517,-0.009160308,0.005594087,-0.10774089,0.009117901,-0.0054672062,-0.035011448,-0.0022660117,0.012022444,-0.0048610717,0.09430548,0.058535963,0.021385366,0.0027619898,-0.023575911,-0.022374207,-0.094852686,-0.010268057,0.034910772,-0.009279142,-0.01663447,0.0674364,-0.031802636,-0.028152443,0.066498265,0.03009102,-0.019696033,0.07065452,-0.0005056195,-0.002866622,-0.076752454,-0.086070634,-0.1484786,0.014920951,0.01316438,-2.5259007e-08,0.059806075,-0.021562668,-0.015514878,-0.036520086,-0.015126816,0.06778677,0.018593445,-0.0063291886,0.076919556,-0.036452003,-0.0091952775,0.04742257,-0.027437882,0.07476854,-0.0018588608,0.036872484,0.057016186,0.08616065,-0.016520604,-0.00245747,-0.045262344,0.07632401,-0.15082029,0.06964429,-0.0031385396,-0.01495404,0.004975357,0.10272764,0.021057233,-0.040637545,-0.03805231,0.015825503,0.039528906,-0.053559154,-0.07626071,0.08003805,-0.023021325,-0.023046939,-0.00038484673,-0.0040017306,0.035543714,-0.015696744,-0.003726975,0.007366341,-0.018538741,-0.004320602,0.046673313,0.00044462318,0.014284682,-0.040153127,0.116011046,-0.0535771,-0.007081769,-0.0069509572,-0.052781645,-0.023500137,-0.025871519,-0.08323555,-0.066619776,-0.010568585,0.02426695,-0.053899743,0.14822914,-0.030101134 +4.1.1.42,Requires ATP.,384,0.99999994,-0.028612431,0.039120086,0.01628997,0.0038213448,-0.05259959,-0.042727824,0.04305336,-0.0034477788,0.038832348,0.019429062,-0.011332476,-0.005994085,-0.077571616,0.09656996,0.021173457,-0.04091025,0.021105843,0.06632819,0.0028716691,-0.015870295,0.0815053,0.040351726,0.027118582,0.0011912035,-0.06432566,0.017575901,-0.028921656,0.0068365117,-0.015588346,-0.028354637,-0.06924677,-0.02444685,-0.02599995,-0.047772717,-0.04418624,0.10319454,-0.07757831,0.024901658,0.030586526,0.019437324,0.05679453,-0.09269998,-0.015495228,0.086495034,-0.020719327,-0.021069001,0.03341301,0.029388577,0.059313662,-0.044761132,-0.07072043,-0.016359143,0.010721083,0.0045024953,0.024643684,-0.014926887,-0.050062824,0.010357791,-0.04508075,-0.013877243,-0.027144069,0.0078860875,-0.06186595,0.069542006,0.07495507,-0.048149828,-0.01707243,0.039872073,0.047140412,0.03845552,-0.015932748,-0.011370204,-0.03448544,0.045860294,-0.01921173,0.013507585,-0.017239343,-0.058454428,0.118324906,0.015628915,-0.016045876,-0.0026576715,0.030518832,0.0494484,0.078136854,0.012152135,0.021981046,-0.020957852,-0.10731429,0.044383425,0.016743613,-0.002067589,0.02453189,-0.0014789024,0.0014962031,0.022388766,0.003154827,-0.035081606,-0.098037034,0.069299884,0.022504473,0.06983226,0.030535325,0.046787757,0.003601982,0.013660135,-0.020599611,-0.016153973,0.03298988,0.053445105,0.02408416,0.0010939375,0.02091759,0.009590293,-0.0324832,0.08236387,-0.00059221906,-0.039063573,-0.019270988,0.015675751,-0.100326195,-0.10023353,-0.019204259,-0.013345004,-0.043107394,-0.007384373,0.052917503,-5.369479e-33,0.016026147,-0.0494656,0.06813695,0.03763489,-0.04596337,0.004266927,-0.06601087,-0.0730049,-0.0054667816,-0.13009812,-0.020978196,-0.08933358,0.0058386754,0.0027628096,0.02559314,-0.039961785,-0.036862414,0.06410581,0.119147986,-0.044662658,0.007007945,-0.025933674,0.016778117,-0.07449644,-0.0046139313,0.024470206,-0.007601348,-0.06392706,0.01789388,0.0033969546,0.00026802692,-0.04643677,-0.051142868,-0.0026565837,-0.016493147,0.026462272,-0.05692362,-0.030454177,0.028562572,-0.029199084,-0.026921067,0.040373303,-0.010046751,-0.019160992,0.049423497,-0.052083608,-0.013371202,0.0675161,-0.04853487,0.061211646,0.114938825,-0.05503339,0.07050976,-0.01760474,-0.0031631803,-0.010899386,0.034552615,0.0031029687,0.00905185,0.096651495,0.03825509,0.066621125,-0.05657757,0.11790865,0.033146136,0.049333647,-0.10390855,-0.042500768,-0.037321363,0.06400072,-0.07994287,-0.061770067,0.038681343,-0.035981815,-0.0026599902,0.020435968,0.022433074,0.010995147,-0.056608927,0.039969243,0.03457246,-0.09892194,0.02464029,0.0419554,-0.033000685,-0.0012415753,-0.011238836,-0.0032867182,0.0800876,-0.0054475227,0.09281026,-0.07952532,-0.060136877,0.0527935,0.008453257,3.8771863e-33,0.05262237,-0.060271926,0.093226805,-0.0391868,0.048883855,0.040124808,0.0043365564,-0.13073942,-0.023709249,-0.021605302,-0.012559491,-0.0362165,-0.07148659,-0.02075307,-0.0046387864,0.0019677093,-0.028663317,0.04047669,-0.020127708,0.016713189,0.00058072014,0.12642317,0.06638313,0.043563433,-0.0022838921,0.030729389,-0.045455083,0.032519385,-0.00929451,0.011465864,0.028494375,-0.024362022,-0.097314954,-0.023265889,-0.051334143,0.03388213,-0.0010151012,0.09469274,-0.01633542,0.026696028,0.0582335,0.07990839,0.008013972,0.095891975,0.041471254,0.04629757,0.0568167,-0.010212162,-0.030543432,-0.0036702354,0.007310286,-0.017965417,-0.07712123,-0.0025109886,0.052209076,0.0025752552,-0.004223106,-0.011745519,0.016406145,-0.055485375,-0.032229785,-0.031125143,0.0039753504,-0.04941367,0.016220221,0.0070322813,-0.07312025,0.027422369,-0.035920642,0.052288137,0.041684493,0.09588136,0.014146875,-0.06271398,0.0031881472,0.11708409,-0.020003498,0.0118696885,-0.024113698,-0.036709808,-0.13065079,0.0524505,-0.086282685,-0.056882493,0.057199717,-0.0683492,0.035644997,-0.11089497,-0.007016321,0.032346588,0.025968099,-0.05098004,-0.0037162104,0.061554424,0.034611136,-1.165588e-08,0.01769645,0.013854357,0.077655055,-0.0309877,0.027003923,0.077035114,0.08668672,0.029999051,0.119653665,0.010411289,0.04535734,0.08159399,0.13845007,0.05255858,0.07445208,0.023057502,-0.0648906,0.05726715,-0.08667324,-0.0675176,-0.10053206,-0.100150675,-0.05714585,0.1656881,0.0473876,-0.08391541,0.06682429,0.037454676,0.025450025,-0.025492493,0.0480688,-0.037146427,0.014827325,0.020333612,-0.03949552,0.015315933,-0.0064771743,0.01280437,-0.05366662,-0.04600818,-0.12780747,0.026648631,-0.05717927,0.052171413,0.025576226,0.006272395,-0.07435277,0.048054658,-0.03407684,-0.033548974,0.011585943,-0.033534724,0.028340288,-0.05078219,-0.04682264,0.042157013,-0.021491332,-0.027723607,-0.011114431,-0.049072303,0.07333798,0.0070389197,0.15672521,-0.021551186 +4.1.1.43,"The enzyme from the bacterium Azospirillum brasilense also acts on some other substrates, including (indol-3-yl)pyruvate, with much lower efficiency. However, it only possesses classical Michaelis-Menten kinetics with phenylpyruvate. Aliphatic 2-oxo acids longer that 2-oxohexanoate are not substrates. cf. EC 4.1.1.74, indolepyruvate decarboxylase.",384,1.0,-0.0227247,-0.07305797,-0.06972465,0.009808381,0.036522668,0.0465306,-0.028836906,0.008423313,0.058225222,0.067176685,0.051628124,-0.050161876,-0.07450912,0.104591995,0.0042080046,0.018707693,-0.06776383,0.014971289,0.025121022,-0.030056406,0.12752037,0.04947325,0.011895418,-0.01785461,0.013122083,-0.017046208,0.008625111,0.006690347,-0.014059895,-0.06428223,0.0084307175,-0.048701964,0.08516927,-0.077651516,0.088221535,0.09626683,-0.03040449,-0.09747066,0.0934502,0.0048944,0.04068484,0.015212251,-0.014173238,0.0159496,-0.054929543,0.04896668,0.09385384,0.008996692,0.023603942,-0.018530056,-0.037364487,-0.0014502477,-0.08575345,0.027363967,-0.019723102,0.034862272,-0.009379632,0.0059768474,-0.12619877,-0.03522192,0.013790944,0.036794607,0.029421506,0.017184151,-0.072648324,-0.062263783,0.033207245,-0.06898797,0.00090603373,0.012824984,-0.074754804,-0.07656407,0.060070414,-0.009000782,0.0043100575,0.012429297,-0.0064223483,-0.05746884,0.006836952,-0.08404576,-0.0055407267,-0.043276682,0.015613556,0.011880771,-0.063278675,-0.0630707,0.008630154,-0.066820614,0.04962593,0.056338534,0.029111553,0.030243471,0.052683394,-0.07319532,0.02899189,-0.023865465,0.036014784,0.04959773,-0.01527519,-0.032831013,0.00972702,0.062056784,-0.05036903,-0.07229404,-0.017656464,-0.007177918,-0.05580036,0.06905602,0.021512493,0.058398657,0.010141257,0.029501254,0.040216595,0.013656186,0.0088446755,0.056894045,0.02829169,-0.08472855,-0.1266621,0.02262096,-0.0054632607,-0.07122615,0.0388528,0.048059687,-0.08620507,0.04907504,-0.07049617,2.9031526e-33,0.042222925,-0.01386631,-0.022464612,-0.065161675,-0.031319235,-0.0033432532,-0.10837893,0.018108744,0.02270142,-0.07444151,-0.07033138,-0.05355413,0.041536745,0.06278109,-0.009325675,0.0035448936,-0.08053897,0.055465724,0.052310474,0.05246866,0.008483542,-0.0060178526,-0.005351142,0.012225804,0.024675597,0.109702334,0.022786237,-0.03454288,0.009724307,-0.03942352,0.052729893,-0.095300004,-0.10791102,-0.0213096,0.009997258,0.023739077,-0.07031986,0.0117211,-0.059466295,0.07893578,-0.006038238,0.048005894,0.029389914,-0.0049438095,0.026875231,-0.05197936,-0.02357685,0.13961323,0.05161296,-0.00016512252,-0.0027260664,-0.04633296,0.06834064,-0.025249245,0.05612807,0.020672671,-0.012285663,0.06473623,0.069916755,0.008573713,0.032967426,0.038178064,-0.0068860482,0.053289466,-0.047842316,0.08162855,-0.089703955,-0.07873024,-0.011958221,0.11740026,-0.035945475,0.024278583,0.066774145,0.039453063,0.02168788,-0.055193372,-0.059473526,0.00082954025,0.012824906,0.02571571,0.004948628,-0.025544811,0.029676437,-0.03201642,-0.029450733,-0.044013165,-0.036606632,0.042049814,0.00029900373,0.08919643,0.022033716,-0.047421183,-0.030262861,0.03390578,0.013978676,-3.759759e-33,0.10811286,-0.1033213,-0.0019286842,-0.06431586,-0.023702372,0.07724761,0.0054766596,0.06710053,-0.019831963,-0.023950672,0.0416063,0.014708383,0.0482465,0.0034294568,0.0566394,-0.04765209,0.06578408,0.068836875,0.044144377,-0.0076525067,-0.0012502263,0.079104654,-0.025771517,-0.035315998,0.047543235,-0.022040032,-0.082974166,0.055991113,-0.044031575,0.014301982,-0.011613154,-0.007847813,-0.07732378,-0.04635389,-0.028790269,0.059370406,-0.07354818,0.002546495,-0.057956506,0.058346204,0.05120999,0.028574688,0.030917617,0.097610235,0.00084002194,-0.014223188,-0.1374587,-0.025605554,0.0027304573,-0.010771143,-0.007866404,-0.03564329,-0.09502022,-0.053293105,0.067725375,0.09719914,-0.040828187,0.014120896,0.008688165,-0.015531926,-0.10183479,-0.101039484,0.034818865,-0.0721458,0.013486301,0.07637696,0.061123293,0.04068895,0.047951505,-0.014537789,0.10748228,0.018765617,-0.024327401,0.008608657,-0.010727492,0.017763302,-0.06109205,-0.01234949,0.015549135,-0.05630549,0.013860922,-0.008145554,-0.006910696,-0.070762865,0.02096443,-0.021114,-0.010318365,0.018875565,-0.042369243,0.016198369,0.02873866,-0.10996363,0.0061291484,0.005954572,0.024021763,-3.963567e-08,0.014223058,-0.043206975,0.10078364,0.020066028,-0.01941774,0.03356756,0.031974774,0.030607248,0.045975074,-0.07370618,0.07313471,0.025318941,0.045905706,0.051957317,0.07171613,-0.0011783103,-0.052720077,0.08135569,-0.027008772,-0.023652356,-0.08887399,-0.03019257,-0.113472104,0.027249476,0.007298519,-0.018956251,0.09305184,-0.02810816,-0.0554497,-0.077208735,-0.008322823,0.039927367,0.006419582,-0.015614796,-0.028172212,-0.08816892,-0.027286625,-0.011673846,-0.055994764,0.043992747,-0.0068303025,-0.05449053,-0.0625129,0.0388544,0.07618087,0.031526726,-0.0033651819,-0.025025941,-0.0026221904,0.0103302905,0.07153606,-0.012311231,0.005548278,-0.03223242,-0.06915474,-0.006406479,0.049933173,-0.07332248,-0.04046247,0.014114913,0.05771472,0.0075413757,0.14946018,-0.05876926 +4.1.1.45,Product rearranges non-enzymically to picolinate.,384,1.0,-0.060279652,-0.08796008,-0.08594218,0.019468505,-0.0012629153,-0.08600663,0.011170143,0.06946709,-0.025917273,-0.05295003,0.11359441,0.05867063,-0.057663083,-0.0012963776,-8.813396e-05,0.08058184,-0.027144887,0.03594819,-0.039764114,0.0031839355,-0.032359175,-0.041435584,-0.0228487,0.029344114,0.017296292,0.017129295,0.020329539,0.022879804,-0.02767751,-0.09436907,-0.021119682,0.03893159,-0.016602827,-0.052032605,0.05178852,0.11692606,-0.062190846,-0.019844012,-0.040959183,-0.0324464,0.09064552,-0.06339114,-0.03096145,-0.058313657,0.020178795,-0.033633437,0.031140529,0.061339837,-0.004748312,0.0212749,-0.10666491,-0.092524536,-0.11248861,0.010179898,-0.055293724,0.05558547,-0.0026384832,0.057222202,-0.021210603,0.03889211,-0.004655555,0.009638201,-0.06371878,0.01814194,0.053045657,-0.05196442,0.08585599,-0.009147992,0.04904403,-0.017323226,0.023963781,-0.052480936,-0.035729837,0.036829535,0.041544758,0.056059122,0.00446109,-0.018561946,0.09264929,-0.019509364,0.021767547,0.0026885928,0.00073356554,0.069171466,0.07616443,-0.012442803,-0.0004938749,-0.054857682,0.040067863,0.011899888,-0.016203204,0.049613357,-0.058405776,-0.013433991,-0.08065714,0.0021971439,0.006926688,-0.029741552,-0.023241132,0.010788297,-0.034831263,-0.015417978,-0.01468473,-0.08244479,-0.0073422077,0.010899598,-0.01002609,0.0035395436,0.0062446427,-0.030367708,-0.032451034,0.06511213,0.07207213,-0.011415915,-0.011054363,0.025999144,0.028765373,-0.049842518,-0.028320666,-0.03968844,0.0141454935,0.02287109,0.028401528,0.009154883,-0.06690578,0.026795344,0.024711374,2.552516e-34,0.029600952,0.048710614,0.04728056,0.04828886,-0.04007292,0.05503576,-0.09632486,-0.011990961,-0.059661746,-0.008606566,-0.018205266,-0.05309472,0.03835644,0.053604428,0.010900476,-0.08964996,-0.0008297694,0.047397446,0.06867039,0.074745454,-0.04092366,0.04379141,-0.087196514,0.002185648,-0.03322473,0.031120723,0.0016621292,-0.0071704495,-0.013603582,-0.027600141,0.08332328,-0.0014353761,-0.08325927,-0.025305592,0.022759994,-0.013734594,0.040137306,-0.07995482,0.034812093,0.09017686,0.03694607,0.053557727,-0.006942804,-0.014467609,0.084827416,-0.009074651,-0.0760505,0.08543666,-0.031140896,0.016073354,0.047372703,0.023294719,0.09964048,-0.052266903,-0.06990401,-0.05475614,-0.04469827,-0.02919663,0.04820944,0.02812092,-0.052677546,0.086342864,-0.059287257,0.066205315,-0.028042845,0.0053409995,-0.04385695,0.04390259,-0.040979464,0.085912876,-0.0615909,0.020987375,0.026296465,-0.050809443,0.021839056,-0.0287261,-0.053446006,0.013279597,0.05052037,0.006482729,0.013468189,0.053593792,-0.055838197,-0.027770923,-0.088307604,-0.052532148,-0.030784145,-0.020706827,-0.015767008,0.024002464,0.056236975,-0.0216386,-0.02207724,0.023485586,0.014504932,-1.667556e-33,0.063062295,-0.087474875,-0.02073642,0.0062520714,-0.035894465,0.034876604,0.019746,-0.0034367049,0.08216218,-0.03362979,0.036771875,-0.027245602,0.022911247,-0.018666655,-0.024810713,0.11385886,-0.06317023,0.06199668,-0.03631652,-0.039466836,-0.02856263,0.077007234,0.062253084,0.10902203,0.024692675,0.02918294,0.008080733,0.05374469,0.094198845,0.050873425,0.03402619,-0.110913165,-0.036124934,-0.03913216,-0.038964324,0.097546495,0.032261353,-0.008411312,0.040617425,0.0027619803,0.018453995,0.0037402667,-0.04023609,0.06569965,-0.000512861,0.068134844,-0.05467282,-0.024986459,-0.03587378,0.041145813,0.002730747,0.015302034,-0.07310265,0.023113588,-0.020417579,0.01160774,0.072555356,-0.047539346,-0.044665128,-0.011652277,-0.06525534,-0.06807054,0.012316779,-0.12733068,0.022137718,0.093239956,0.063755035,0.03593246,0.05103191,-0.05474196,0.10374815,0.062792934,0.024547555,-0.03410903,0.039535947,-0.0082813185,0.016019683,-0.040873498,-0.008049576,-0.12170215,0.014633532,-0.05905644,0.021706207,-0.08567815,-0.052696764,-0.0805626,0.00058553705,-0.003675464,0.015873274,-0.004177756,-0.012035631,-0.074808456,0.031041585,0.023991048,0.1423428,-2.1284572e-08,0.057939753,-0.050776087,0.081777185,0.011928156,0.0058527333,0.029622946,0.025431244,0.05545678,0.071103804,-0.010487025,-0.054190625,0.13630539,0.04308012,0.023273908,0.028022029,0.038973466,-0.034769177,-0.007885032,-0.05545053,-0.05989816,-0.10822613,0.0012026575,-0.0684122,0.028148673,-0.05466506,-0.11722605,0.031078806,0.0071937954,0.05748658,-0.034762338,0.0582624,0.04110848,0.04724858,0.01369028,-0.049230203,-0.049979985,-0.012076037,0.0092475,-0.009444313,0.036161147,-0.10069371,-0.028474117,-0.06703232,0.00166064,-0.054430287,-0.07380714,0.05347452,0.026462272,-0.016809013,0.08007101,0.049502853,0.048518766,0.04252735,-0.056893628,-0.10299323,-0.018929606,0.02973164,-0.043328613,0.011876801,-0.010330936,-0.056904644,-0.026160963,0.18816109,-0.059589602 +4.1.1.47,A flavoprotein.,384,0.99999994,-0.043602485,-0.055953477,-0.10041998,0.0987541,0.0042448137,-0.010859724,0.11766135,0.07038873,0.058999788,-0.06075136,0.009731344,0.01723871,-0.062368307,0.005337238,-0.08791693,0.023849653,-0.025399506,-0.042351633,-0.06688379,-0.003358398,-0.08870569,0.027560094,0.04605013,0.0037425882,-0.030020507,0.032006472,0.018467,-0.03441763,-0.045847654,-0.028737837,0.06046338,0.049798977,0.03869935,0.002302215,-0.02992041,-0.0063221254,-0.017043909,-0.023989238,0.021531526,-0.016122548,0.060806803,-0.054033954,0.036566973,0.024064196,0.043509196,-0.015659366,-0.029250145,0.12298068,0.041744165,0.05750092,-0.043647632,-0.0761763,-0.123256065,0.023572896,0.016110582,-0.015632642,-0.028275475,-0.024109783,-0.031341914,0.040415965,-0.038875658,-0.0027866696,0.081121795,0.0069291582,0.04320139,-0.100139454,0.0014024228,-0.022313925,0.09895313,0.0133969225,0.045181714,0.029726649,-0.058575645,0.10805363,0.017741429,0.011037363,-0.020627186,-0.013746794,0.102303706,0.021118421,0.08477725,-0.030506562,0.026234934,0.07761661,0.0493982,-0.01570055,-0.019795781,-0.0023034615,-0.07054999,0.05156615,-0.045476135,0.022103308,0.017516665,0.026981851,-0.026568804,0.046875235,0.020656625,-0.070275486,-0.1281704,0.06489905,-0.051976856,-0.061518244,0.06810781,0.025633488,-0.05268849,-0.037994985,-0.016769,-0.020313963,-0.007840068,-0.07568218,0.010121536,-0.044597045,0.03422832,-0.062395837,0.042195555,0.035869546,0.028249921,0.0041977335,-0.029291527,0.031754315,-0.035988405,0.087228484,0.022308243,0.056021888,-0.028274404,-0.003303158,-0.06830595,-2.0013377e-33,0.08175536,0.012586711,0.027638031,0.06856636,0.0007455346,0.060280688,0.010357894,-0.011233057,0.0074632852,-0.03967754,-0.047183115,-0.013965802,-0.01532786,-0.015348028,0.078218795,0.035439335,-0.03560936,-0.0012784902,0.029759184,-0.06996265,-0.049998585,0.056934092,-0.005447631,0.028879765,-0.023380294,-0.019729542,-0.06672018,-0.07115925,0.017245604,0.04301671,-0.03918641,0.023802657,-0.014006892,-0.015578394,-0.021150883,-0.028732963,-0.040140335,-0.10120794,-0.09117002,0.05776465,-0.011814231,-0.02306164,-0.043286387,0.012764909,-0.008656802,-0.02411485,-0.07843009,0.09103707,-0.0524928,0.047614172,0.039830074,-0.04655868,0.16742483,0.067577094,-0.09488555,0.031423964,0.013181722,0.010932014,0.015785398,-0.009284803,0.03601192,0.07468906,-0.053785615,0.034503777,-0.10383158,-0.049613945,-0.06187269,-0.049693402,-0.00049208355,0.059836023,0.068123676,0.0021279515,0.084535256,0.016629742,0.01143524,0.003305857,-0.05791569,-0.0047864257,-0.043587405,0.017313356,-0.052895214,-0.027079571,0.026560068,0.02987427,-0.055321474,0.05441763,-0.009814678,-0.023164414,0.012608765,-0.024844185,0.007118569,-0.02243944,-0.026638476,-0.061056208,0.017656429,9.942023e-34,-0.0028243235,-0.107664935,-0.0452348,0.109784365,0.057378802,-0.037576236,-0.00060954795,-0.022692744,-0.01534325,-0.0052612354,0.021350127,-0.11935165,0.025353467,-0.024759889,0.082680024,0.08482098,-0.018005904,0.08071198,0.052319974,0.015923,-0.07956588,-0.07293342,0.07704628,0.10631335,0.02291263,-0.0017564334,0.07182158,-0.12264125,-0.049727246,0.036191784,-0.075102106,0.033876885,-0.04100713,-0.059006933,-0.03680272,0.030934457,0.01638442,-0.08345418,-0.01089191,0.00950323,-0.008496624,0.028375339,0.062142402,0.09039758,0.078716576,0.077004895,0.035790447,0.096848674,0.06947115,-3.3833098e-06,-0.038548965,0.037147652,-0.023540594,0.13572799,0.018601175,0.0111735305,0.030503944,0.039729126,0.0058352044,0.020861404,-0.029524388,-0.11545868,-0.056502596,0.020566419,0.072291665,0.0710632,0.027435033,0.063175984,0.011261273,-0.045336846,0.119114496,-0.0377551,0.038721118,0.050577734,0.01569965,-0.02125501,-0.034752857,0.07331953,0.0009898178,0.007444973,-0.06346907,-0.060510587,0.035664506,-0.02472008,-0.007126781,-0.14353082,0.016223399,0.009865768,0.00012316725,0.029383302,-0.008305953,0.031317115,-0.107363425,-0.043797247,0.0095361,-1.6019754e-08,0.038205434,-0.04924748,-0.047439277,-0.036155324,0.087726675,0.041416295,-0.021050675,0.0028123267,0.0061940392,0.00067094626,-0.020062184,0.07144231,-0.013140315,0.023744022,0.024415959,-0.03291401,0.034350064,0.019075695,-0.02282047,-0.022456978,-0.03937224,0.0071184607,-0.0077270763,0.0067469724,-0.08784591,-0.04428202,-0.026993811,0.008344881,0.06922219,-0.017654067,0.032253698,0.040606312,-0.028437186,-0.040621083,-0.13802259,0.02331472,0.039288636,-0.040615685,-0.0070842165,0.0491789,-0.12117857,-0.013372172,-0.011241402,-0.04893998,0.016033292,-0.0530407,0.041679695,-0.020074796,-0.004828987,-0.021845661,-0.011959956,0.008115969,0.018384948,0.05125152,-0.009934833,-0.03535877,0.02052093,0.0051775826,-0.042904846,-0.08188846,-0.024873925,0.05429046,0.11014712,0.039773062 +4.1.1.48,"In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)].",384,1.0,0.0028541677,-0.013988085,-0.12614924,-0.016075771,0.10222424,0.028678115,-0.00177911,0.0067230705,0.050972566,-0.015695965,0.033137515,-0.07616129,-0.08947925,0.08275416,-0.03604083,0.041969582,-0.09996318,0.0054891533,-0.019014813,-0.079470925,0.05929453,0.07387097,-0.025147399,0.023202512,-0.038719825,-0.0411641,-0.00479397,-0.05589136,-0.02526077,-0.033027712,-0.013098722,-0.07151199,0.0051627513,-0.06774034,0.035913896,0.112228826,-0.019300072,-0.047611438,0.07220515,0.0148349,0.022786211,-0.022643995,-0.014509239,-0.030812902,-0.032874636,0.08282528,0.05014962,0.031944644,0.043198053,-0.044682156,-0.05783947,-0.04335664,-0.057791553,0.032363642,0.03762346,0.008785602,-0.06914302,-0.022506053,-0.054127943,0.027434766,0.0035063904,0.054460727,0.060111914,0.023688123,0.07292749,-0.03475246,0.018337889,-0.10471848,0.019006638,-0.027452972,-0.0814075,-0.034128077,-0.0069874777,0.04009312,-0.009345295,0.045372166,0.011711169,-0.005418028,0.005824345,-0.017571254,0.021409668,0.012411864,0.0025982151,0.04903866,0.02430576,-0.032860797,-0.04278133,0.0763152,0.036272045,-0.021223972,0.06537095,-0.011654366,0.043178264,0.01155608,-0.01089642,0.006605901,0.01315407,-0.004151004,0.054938175,-0.057699334,-0.026610665,-0.018556925,-0.0039958977,-0.09831114,-0.02598129,-0.015159171,-0.0033369102,0.096194156,0.037753772,-0.0053186645,-0.030770296,0.009441989,0.076805055,0.040860053,-0.000578275,0.06620938,-0.048760336,-0.08443009,-0.002532791,0.04705969,0.023780713,-0.016345702,0.06826987,0.1359459,-0.01663081,0.019137269,-0.12586091,3.8959395e-33,0.057325948,0.046651915,0.040963873,-0.013725205,-0.04712069,0.048607826,-0.02991973,-0.02234346,-0.057651598,-0.026523683,-0.045960747,-0.11940384,0.053500343,0.052758392,0.0040708766,0.037224326,-0.05681508,-0.0015205769,0.02634965,0.06791645,-0.054414324,0.06003418,-0.06379768,0.013349772,0.049356353,0.07350247,-0.03781026,-0.0018625156,-0.0014750041,-0.022490818,-0.01436376,-0.02195221,-0.13850904,0.019204961,0.038470924,-0.056486942,-0.0005478855,-0.02410682,-0.1062841,0.0068921708,0.0029323066,0.04205624,-0.017726744,-0.007646919,0.09465639,-0.0011653762,-0.07954666,0.1128734,0.092530295,0.02161373,-0.028830083,-0.01879196,0.13110098,-0.05424222,-0.048897628,-0.032640666,-0.058274105,-0.023784922,0.031908594,0.03277462,-0.107974686,0.02084032,-0.05570354,-0.010469233,-0.033036377,0.010809449,0.0121262465,-0.082517065,0.0044817,0.066228665,-0.059755187,-0.030948872,0.05214154,0.017869486,-0.0069770576,-0.08645848,-0.05985052,-0.05302894,0.0036115474,0.07750308,0.0107351765,-0.02666228,-0.00048479286,-0.032261983,-0.02188422,-0.029564615,-0.0054739877,-0.0690318,0.015567191,0.04644876,0.0027195958,-0.051405773,-0.09287024,0.07197493,0.0026445456,-5.7689663e-33,0.07495036,-0.08300634,-0.0007117917,-0.057591904,-0.04481212,0.064138874,-0.00036248713,-0.0016676501,0.049087394,0.0049943635,0.054585904,-0.07180701,0.086112395,-0.039693847,0.010755025,-0.013626562,-0.028667778,0.11117531,0.11530966,0.016154833,0.00949807,0.03923202,0.004397006,-0.010554049,0.078968614,0.03852231,-0.09731943,0.103639856,0.013494527,0.02086279,-0.0018538458,-0.023851667,-0.06459855,-0.018007047,-0.032448564,0.026529474,-0.07320731,0.032435022,0.086642966,0.0096702315,0.05925087,0.06800031,0.06133512,0.040827047,0.010053222,0.111605614,-0.043293763,0.060011566,-0.008963348,-0.073044114,-0.045344066,-0.032755136,-0.027373556,0.026709119,0.04756311,0.07317833,-0.025099838,0.09481445,-0.037145805,-0.039180156,-0.059438508,-0.08896206,0.09159168,0.0069216727,0.021346772,0.05741991,-0.019959122,0.0009256838,0.05955976,0.04558348,0.04919555,-0.023536747,0.022030078,0.06800096,-0.03541057,-0.062141526,-0.09400609,-0.08003967,0.018900802,0.0077285767,0.0465717,0.0034302499,0.059256908,-0.03639983,-0.022357965,-0.03215963,0.048713844,0.12202421,0.022670785,0.0060374686,0.013555754,-0.007932135,-0.04291376,0.04846049,0.039624896,-4.7892048e-08,0.070147105,-0.08050727,0.015778037,-0.1443289,-0.022224676,0.03069313,0.033053037,0.034594323,0.022519557,-0.0061461776,0.020405853,-0.0049501895,-0.008093721,-0.0030942324,0.031304896,-0.029343486,-0.023913454,0.033708747,-0.010241784,0.0024260795,-0.038244113,-0.052526433,-0.06679555,-0.012892348,-0.004549883,-0.043084595,0.06853675,0.026935281,-0.0320185,-0.046397243,-0.06099604,-0.01259809,0.010506719,0.010808626,-0.06049469,0.065680996,-0.105183944,-0.028786551,0.003163988,-0.0015521512,0.006918679,-0.052216515,-0.060219727,0.023696445,0.06806447,-0.04345291,-0.010467766,-0.04961178,0.017944671,-0.06039489,0.029393006,-0.03365225,-0.017529773,-0.060742375,-0.06204838,0.004166627,-0.04093011,-0.05067452,0.0008445384,-0.035515655,0.054364424,0.03880132,0.16914864,-0.057062823 +4.1.1.50,The Escherichia coli enzyme contains a pyruvoyl group.,384,1.0,-0.04875021,-0.088941626,-0.086020604,-0.035484746,0.021973569,0.044195477,-0.10212785,0.028759642,0.04213419,-0.039347127,0.045688175,-0.046293825,-0.082073875,0.080402076,0.036725145,-0.043945216,-0.11143012,0.015688859,0.054022036,-0.06935634,0.054161813,0.014950913,0.036460824,0.0067424835,-0.018115284,0.062505804,0.049746845,0.036398795,-0.042449582,-0.035330717,-0.03818478,-0.022129495,0.022302153,-0.07728384,0.18068916,0.04690231,-0.047703605,-0.029903239,0.107472725,-0.047789324,0.02932563,0.038059466,0.012422359,0.00954907,0.004782111,0.037937235,0.101199284,0.024937216,0.03815785,-0.050767824,-0.025028875,0.0010408267,-0.03413076,0.06452558,0.03593244,-0.012379268,0.05925333,-0.08668536,-0.025771108,-0.07255071,0.053715352,-0.019444086,0.015944313,0.021786802,-0.039410915,-0.034704924,0.09962243,-0.03208255,0.027472872,-0.044894084,-0.051647082,-0.0013796828,0.03238823,0.09572007,0.016123826,0.025689837,0.03626504,-0.05224256,0.017134937,0.041121427,0.027443388,-0.036881655,0.0062034396,0.07386038,0.026329232,-0.010662518,0.031007063,0.0017497152,-0.0048819566,-0.0069034924,-0.015281868,-0.03996441,0.002787712,-0.09434948,0.041133903,0.007616998,-0.023421915,0.005703449,0.030428419,-0.0689314,-0.040202457,-0.024853148,-0.014507767,-0.025613723,-0.061581235,-0.006706015,0.019541863,0.061712615,0.034622513,0.013950747,-0.04603478,0.056562442,0.0037586421,-0.0077250763,-0.02743256,-0.066269286,0.1025445,0.011771797,-0.056442935,0.08570735,0.048094746,-0.04107874,0.06442392,0.108422846,-0.061775602,-0.02322015,-0.107891485,3.0757019e-34,0.03146177,0.04194023,0.03453816,-0.067723274,0.06277633,-0.03898006,-0.06504729,0.0028741732,-0.10566286,-0.02332913,-0.11230161,-0.09741706,0.016591765,0.06514329,-0.052313235,-0.010280659,-0.1051676,0.057100702,0.04465468,-0.074878894,0.015053403,0.08360748,0.030174097,0.066405304,-0.021809584,0.03945229,-0.074224986,0.056565247,-0.009901916,-0.011926314,0.04053561,-0.07002955,-0.15014195,0.04416216,0.05997778,-0.03751542,-0.039397314,-0.0815163,0.035028685,0.035435054,-0.05369844,0.023570973,-0.029227622,-0.031496,0.035979014,-0.062816896,-0.09175467,0.015566384,0.006458392,0.072868854,0.0127851805,-0.015933827,0.032928452,-0.06876496,-0.062973514,-0.011414233,0.025497796,0.03391322,0.029110678,0.0103196055,0.04246196,0.14750527,-0.044604015,-0.010575757,0.009116489,0.0063867164,0.078083254,-0.0020140791,0.058942243,0.08780255,-0.032077342,0.0040295343,-0.022424795,0.045934953,0.06155518,-0.0029473791,-0.06552758,0.01326886,0.012312451,0.0060979784,-0.019257948,-0.05921462,-0.022275258,-0.027067414,-0.058269817,0.016061872,-0.045655277,-0.027207892,0.0032664887,0.037110034,-0.0034014317,-0.07076816,0.008007207,0.06584708,-0.03515886,-1.9449094e-33,0.05578098,-0.06101724,0.049169317,-0.07063669,-0.09026474,0.0034962068,0.032332074,-0.032356527,0.03300641,0.04175984,0.01989962,-0.052220333,-0.035240255,0.0022639737,0.041703187,0.034942683,0.01092819,0.04682023,0.040235415,0.012462759,0.039147433,-0.013520243,-0.026028698,0.045621183,0.02458306,0.029578632,-0.0016393604,0.05345611,0.032952815,-0.015841823,-0.014495693,-0.028703358,-0.04767129,-0.053593703,-0.06941613,0.04140301,-0.06382871,0.03680477,0.050928034,0.0061488887,0.085220195,0.09667894,-0.022641828,0.033601172,-0.030812882,0.035050847,0.040037453,0.012858738,0.004977755,-0.021033404,-0.0126340855,0.033394024,0.039797332,-0.06647006,0.0686541,0.020115044,0.03293802,-0.016545733,-0.04993889,-0.039590355,-0.0025468506,-0.08878654,0.0021469668,0.035494916,0.02458335,0.045912333,0.044010933,-0.02989032,0.025870094,0.012507886,0.0774788,0.022469988,0.006523662,0.03615579,-0.05443164,-0.0134134125,-0.051489886,-0.015350715,0.048911612,0.010627776,0.0469529,-0.0086980555,-0.032826725,-0.032569934,0.013792547,-0.07059338,0.01061419,0.09421937,0.06666781,0.012081949,0.05415664,-0.0057795965,0.07603602,0.025266359,0.05796898,-2.2253012e-08,0.08802345,-0.05528066,0.06328978,-0.016161531,0.05783761,-0.031528216,-0.026172495,-0.029905943,0.054788973,-0.006806004,0.033626277,0.01539044,8.208845e-05,-0.04127964,0.03886204,0.06487415,-0.075993195,-0.033529192,0.032650817,-0.0029720042,-0.05228812,0.0022381078,-0.13904777,-0.00018816267,0.029468225,-0.020001212,-0.046660483,-0.023214797,-0.06271921,-0.008789022,0.009516601,-0.032535963,-0.02013882,-0.03538601,-0.08515835,-0.032090604,-0.06853577,-0.028037233,-0.018927403,0.0067747324,0.033835307,0.015522788,-0.010610821,0.018972695,-0.0053425995,0.10019853,-0.078183144,-0.028346613,-0.06812916,-0.018386154,0.12126519,-0.0314059,0.00047703309,0.02411145,-0.18261632,0.066093616,0.009986104,-0.075268924,-0.0034936427,-0.08479673,0.019611586,0.011468807,0.16408242,-0.055593334 +4.1.1.53,A pyridoxal-phosphate protein. Also acts on tyrosine and other aromatic amino acids.,384,0.99999994,-0.015168114,-0.07249917,-0.06927163,-0.087211035,0.03485545,0.04189318,0.08973622,0.008265256,0.1430454,0.072553955,0.04477094,0.03622847,-0.0776519,0.083089866,-0.008510544,0.040606968,-0.039014127,0.010786224,0.017394148,-0.090980105,0.063222036,0.07110993,-0.0013278822,-0.019700328,-0.041552983,0.03972145,0.03322808,0.048558954,-0.023545306,-0.028947711,-0.04067025,0.007712384,-0.04077918,-0.0579224,0.0059930687,0.10617244,-0.106565915,-0.015197191,0.025546858,-0.0203255,0.08542193,-0.06053449,-0.047503673,-0.012410446,-0.06374483,-0.007516189,0.06508548,0.044232804,0.08203691,0.005356457,-0.09000338,-0.024083043,-0.00076020934,-0.04834737,-0.0155785,0.07021633,0.0031968432,0.038178463,-0.06085698,-0.00552305,-0.012411607,-0.006669795,0.049470775,0.0056986334,0.065504506,-0.03190556,-0.0018887019,-0.023481444,0.001208312,-0.06599841,-0.01835886,-0.03285981,0.08850667,-0.013055127,-0.034271304,0.060056485,-0.04906054,-0.038189586,-0.0070395246,-0.030657155,0.0045816316,0.031126898,0.014243349,0.08523808,0.06521447,0.01359612,0.008642997,0.009933476,-0.01232397,0.0028063036,0.033638757,-0.02594614,0.044863105,0.01733592,-0.03622561,-0.021545218,0.010779205,-0.01433045,-0.048866544,-0.014435568,-0.017075246,0.010329422,-0.017717492,-0.01594727,-0.0933375,0.03202063,-0.030917816,0.0417243,-0.0141970115,-0.034697104,-0.06964581,0.04891465,0.03872054,-0.01287008,-0.022514978,0.017446233,0.058337778,0.016164621,-0.023567,0.011340328,-0.006147188,-0.038871445,0.017435558,0.080853514,-0.027147766,0.005572217,-0.0504365,-6.242493e-34,0.08439871,0.06668257,0.062031075,0.046846487,0.019623816,-0.006864721,-0.052140526,-0.057802383,-0.011782406,-0.013774486,-0.039425414,-0.056172255,0.062223613,0.006735179,-0.06070176,-0.017243547,-0.11473931,0.06868191,0.069030315,-0.02277956,0.013033421,0.14621915,0.0065674502,0.03467824,-0.03348225,0.064094506,-0.06435573,-0.02129959,-0.036520515,-0.002350176,0.0015196059,-0.041369613,-0.12744899,-0.024600845,0.047655188,-0.059491012,-0.028810589,-0.060928218,-0.027356744,-0.008532013,-0.03530254,-0.0486466,-0.033467885,0.028915761,-0.014145792,-0.09999297,-0.026730936,0.058062118,-0.0051090824,-0.0027981712,0.080715396,-0.12984881,0.09574339,-0.01760691,-0.12001948,-0.039414663,-0.058165647,-0.06455849,0.045112763,0.07455888,0.054731462,-0.06787318,-0.059556782,-0.0018377581,0.022335669,-0.05589771,-0.0058368277,-0.07123647,0.0379202,0.069302514,0.03467251,0.0030267145,0.09998374,0.06797995,-0.013862769,-0.0005508324,-0.07760516,-0.023147952,-0.001496219,0.074118234,0.0025849615,-0.11681431,0.008610729,-0.020242274,-0.049767725,0.026742814,0.052150235,-0.10165623,0.028444372,-0.017000565,0.033594526,-0.1011996,-0.087453485,0.0017673171,-0.008805943,-1.544123e-33,0.07519642,-0.06308969,0.014631574,-0.034710616,-0.053509638,-0.0026459324,0.04777309,0.002341483,0.008752927,-0.01130843,0.06835011,-0.047201257,0.018563962,-0.08685246,-0.052855346,-0.02216003,0.004396168,0.027028432,0.006675878,-0.0008189646,-0.044067755,-0.005591063,0.035108548,0.054468386,0.06087074,0.07809774,-0.038760826,0.033750266,-0.07505507,0.060255565,0.018073129,0.038948625,-0.020413022,-0.055883564,0.012882602,0.03404467,-0.066214465,-0.044825252,0.012463572,-0.041987825,0.031923443,0.012372345,0.115261324,0.0059903245,-0.00080873497,0.05969294,-0.04368741,-0.003452187,-0.06645391,-0.04054507,0.03495679,0.058916874,0.02208126,-0.031340845,0.024581712,0.033349387,-0.05292314,-0.012494141,0.032510754,0.06685671,0.008895216,-0.037706703,-0.0027988446,0.081144616,-0.0036032144,0.04138142,-0.022610571,0.017897505,0.10162522,0.058177643,0.039224997,0.055301763,0.08183559,0.10984989,-0.043372612,-0.036026023,-0.04621089,0.018841607,0.052786253,-0.048844762,-0.0445115,-0.010000328,-0.051744778,-0.07187163,-0.0055427095,-0.01629849,0.042166132,0.07204072,-0.006698372,-0.010459407,0.017049808,0.008941931,-0.048000056,0.06698233,0.055788673,-2.6364814e-08,0.07799081,-0.04517098,0.0379688,-0.058415525,-0.050644137,-0.016059928,0.077235654,0.026206437,0.06645458,-0.055745997,0.025517473,0.015320601,0.033188183,-0.015545986,0.012120707,0.06548948,-0.020253103,0.0058465544,-0.02611048,-0.11223063,-0.022450533,0.032177437,-0.10278597,-0.0043543237,0.08339811,-0.026039446,-0.0187472,0.068962455,0.039950848,-0.027580542,0.0564219,-0.06044994,-0.010563718,-0.054500725,0.023141779,0.12994342,-0.065563574,-0.04105497,-0.040071927,-0.015865752,-0.061576664,0.011934165,-0.032363206,-0.030838326,-0.0059441817,0.070262484,-0.06535396,0.049941037,-0.034001302,-0.0036730361,0.06238267,0.048583616,-0.03479224,-0.038851596,-0.1890775,0.009569461,0.033963066,-0.008838854,0.027308723,-0.10385151,-0.022701042,-0.019045753,0.10239899,-0.05055701 +4.1.1.56,Also decarboxylates other C14 to C16 oxo acids.,384,1.0,-0.028213805,-0.034786373,-0.09057208,-0.011904188,0.05148529,0.0073768473,-0.081127115,0.029616054,0.0020793444,-0.059635296,-0.012924465,-0.02503615,-0.088284954,0.031303577,-0.057788152,0.053696375,-0.018873421,0.11119769,-0.052610666,-0.022846391,-0.035407547,-0.0042973915,-0.017558368,0.038824517,-0.0016924752,0.016234988,0.023414025,0.0013241215,0.012510776,-0.07455302,0.030572599,0.03291363,0.049029965,0.010630814,-0.006093007,0.06793404,-0.016991924,-0.08809801,0.11559496,0.022151755,0.011023903,0.045663733,0.10749908,-0.020855268,0.020820878,-0.018430749,0.011587049,0.008448686,0.046670925,-0.021800797,0.041303463,0.028105289,-0.10797676,0.03113209,-0.00981116,-0.026088212,-0.091973096,0.0066006496,-0.0047949287,0.05002926,0.012925607,-0.00028953113,0.017890606,0.036914594,-0.011056346,0.008920482,0.003275641,0.014158934,0.014243262,0.010771774,-0.098238185,-0.04751766,0.1267139,0.038799886,-0.038137503,0.06509557,0.0005916435,-0.097826235,0.09533853,-0.024151873,-0.014254543,0.10667818,-0.024710422,0.057020918,0.051367678,0.0047097043,-0.0013355201,-0.020978987,-0.031679917,0.019989777,0.030134909,0.02296927,-0.008898219,0.0064095976,-0.11304317,0.0056701624,0.09040956,0.05476408,-0.00825286,-0.009247634,-0.01758482,0.028574087,-0.01658007,-0.12394049,-0.058840435,0.0023718073,-0.013527447,0.054584783,-0.0070354585,0.04451243,-0.077355124,-0.026416149,-0.035864715,-0.014431104,0.027565392,0.07268455,0.017286869,-0.050377473,-0.02733168,-0.02835949,0.04107572,-0.067006014,0.03930982,-0.002816762,-0.04338558,-0.043337453,-0.021073513,3.26717e-33,0.029033286,0.031730156,0.0648882,0.03212344,0.024998356,0.009296238,-0.07650722,0.020464813,-0.025578465,0.0012170576,-0.059698924,0.03332111,0.027412238,-0.020517198,-0.010962042,-0.06468237,-0.021560809,0.037071608,-0.020770434,-0.009166573,0.011322423,0.09695421,-0.020319305,0.014568076,0.031114385,0.019464388,-0.002347196,-0.050721258,0.02668255,-0.018564472,-0.0063763782,0.03661422,-0.033805996,0.025191445,-0.00126333,0.033448216,-0.10513927,-0.053424142,-0.0025127523,0.069450855,0.09790355,0.0024908397,-0.06291914,-0.04912687,0.05185254,-0.09436502,-0.04876209,0.07714792,0.010558211,-0.0061876955,-0.0040097013,0.002924397,-0.016190125,-0.041505385,0.0014083349,-0.04230194,-0.04423875,0.029998157,0.07273345,0.021408789,-0.034348663,-0.006305539,-0.084557444,-0.033210676,-0.010724214,-0.01977289,-0.090482,-0.063066505,-0.06619647,0.0149917435,-0.04127868,-0.062416084,0.08901313,0.0384159,0.045518212,-0.012925576,-0.03813768,0.022406707,0.07196509,-0.030431824,0.0130330855,-0.018709475,-0.029764283,-0.03284643,-0.046540037,0.019076426,2.0594915e-05,0.040747054,0.034632683,0.058874775,-0.015143145,-0.108134836,-0.046542276,-0.052704997,-0.023059092,-4.2966916e-33,0.10347557,-0.11463667,-0.026901143,0.019736443,0.014149998,0.026166635,0.0383372,-0.11555272,0.025705094,-0.045569755,0.0764093,-0.053422596,0.035020288,-0.007553004,0.03077611,0.015191783,0.03916439,0.09825675,-0.039235145,-0.02117388,0.025077093,0.056490462,-0.011831839,-0.022103991,0.07263094,0.04375636,-0.031203013,-0.010076517,0.065028384,0.10273489,-0.08921551,-0.010734847,-0.030407215,-0.04280644,-0.068986304,-0.014601956,-0.028783768,-0.0118093835,-0.037613146,0.02870467,-0.013375464,-0.006074651,0.0278229,0.106347464,0.048678,0.00010263,-0.07293715,0.012737214,0.05088493,0.027165903,0.057661384,-0.0160242,-0.12596135,-0.010454521,0.03818999,0.08655193,-0.009795098,-0.09627678,0.062312756,-0.037672527,-0.08361026,-0.072563685,0.007310732,-0.10179128,0.022516238,0.047110796,-0.08583118,0.055900186,0.037203886,-0.046279814,0.19131668,0.041629557,0.054692514,0.0044618845,0.018876262,-0.14074077,-0.01622619,-0.053679697,-0.009264931,-0.023621062,-0.071765825,-0.018964902,0.05685285,0.03434006,-0.008592769,-0.025371507,0.025941033,0.023927605,-0.038420755,0.054905538,-0.03305809,-0.014207527,0.044285458,0.09150037,0.03638907,-2.080105e-08,-0.016659802,-0.018393712,0.07294466,-0.018460937,-0.06470736,0.072921716,0.03762153,0.03419397,-0.0030703035,-0.07408429,0.048637725,0.07496246,0.018800758,0.023515176,0.032962505,-0.008867904,-0.0724959,0.019218648,-0.022293154,0.028432023,-0.062124763,-0.0011443653,-0.01018377,0.04911831,-0.00820693,-0.0061854767,0.085656434,0.027231498,0.032776367,-0.020129155,-0.014715041,-0.018884405,0.097177066,-0.097660206,0.04534706,0.008713602,-0.0018134236,-0.028452374,-0.09867149,0.04600886,0.02588859,-0.110569626,-0.07062609,0.04107199,0.0810905,-0.047855724,-0.031119967,0.038501915,-0.051892046,0.022280473,0.097488046,0.0008441231,-0.035252716,-0.03456151,-0.0041495045,0.012172657,0.025956197,-0.06880362,0.0069672,-0.02744327,-0.023233172,0.004370457,0.21518011,0.0006827383 +4.1.1.64,"A pyridoxal-phosphate protein. Acts on 2-amino-2-methylpropanoate (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and 1-aminocyclopentanecarboxylate.",384,0.99999994,0.016237939,-0.11002013,-0.03620512,-0.09986105,0.029686123,0.06791471,0.05472731,0.025333768,0.06471075,0.042607483,0.055891145,-0.007354973,-0.039763164,0.11156327,0.0030178607,0.07596227,-0.09608929,-0.0063429726,0.0384772,-0.048729785,0.08861944,0.0555463,0.004330623,-0.036035,-0.05002464,0.09992157,0.03963302,0.05430095,0.028105939,-0.027528087,-0.026975581,-0.014899717,-0.06829165,-0.060020212,0.07018671,0.10380824,-0.10274356,0.01756789,-0.001699306,0.0011904708,0.09710159,-0.06147854,-0.051255044,0.009955572,-0.07856972,-0.05262524,0.09239686,0.029726759,0.06680532,-0.012304238,-0.058621578,-0.043801043,-0.019773273,-0.012237774,0.024026116,0.07368781,0.051904596,0.028469896,-0.025626818,-0.008181119,-0.035240766,0.005995024,0.018976763,0.014648792,0.056509577,0.0008628554,-0.013379355,-0.018288324,-0.008377799,-0.056017168,-0.06290663,-0.017781027,0.07352286,0.01085381,-0.025517873,0.02447794,-0.05721611,-0.0050512003,-0.031943418,-0.014431475,0.02608173,-0.03982893,0.04020501,0.023631841,0.053155422,0.02647929,0.010121655,0.043640006,0.017800255,-0.022882517,0.018807476,0.013804405,0.052990824,0.013416496,-0.04019078,0.0048576724,-0.03421162,-0.0029111987,-0.012116618,0.007227283,0.019085092,0.003419696,-0.057905044,-0.07328082,-0.014332315,0.0031686355,-0.058911454,0.022792593,-0.028883751,-0.009457272,-0.05335296,0.015327233,0.02500949,0.013765443,-0.03183319,0.07345283,0.039019726,0.027214285,-0.055021565,-0.011260437,-0.0046291347,-0.025874848,0.012612908,0.027094092,-0.05291622,-0.030716492,-0.10913613,4.65093e-34,0.048751343,0.047511637,0.066515744,0.029335342,0.054789796,-0.025583657,-0.025824655,-0.025834495,0.016576646,-0.025123056,-0.04218513,-0.041049987,0.05140135,0.043146227,-0.06465823,-0.04347345,-0.07908517,0.044852752,0.05803881,-0.0665623,0.00399742,0.13218364,-0.019756176,0.03863788,-0.013925591,0.03808836,-0.029329598,0.003619791,-0.028835014,-0.013028399,-0.027224602,-0.07884835,-0.17721362,-0.034893576,0.07437659,-0.09375106,-0.01919373,-0.102011,0.000102531674,0.018954054,-0.060810853,-0.061125793,-0.037928957,0.021826377,0.026254544,-0.115134895,-0.05491481,0.088617496,-0.0062036496,0.022264568,0.064156674,-0.08076928,0.034652855,-0.02942603,-0.16762851,-0.032634266,-0.040582642,-0.047666535,0.01586104,0.055276386,0.029310651,-0.044057153,-0.030754002,-0.055002645,-0.0037547112,-0.014804865,0.005943263,-0.07413407,0.027863719,0.073722236,0.033148378,0.008905995,0.068688154,0.03203532,0.014213293,-0.037052575,-0.092789926,0.033625167,0.019733198,0.07677462,0.023872668,-0.05687286,0.005867542,-0.049599715,-0.082281046,-0.013911923,0.0372546,-0.10883233,-0.017172264,0.003236643,0.04089912,-0.08690696,-0.06570795,0.024214022,0.03140025,-2.1751827e-33,0.026901575,-0.02907364,0.076120414,-0.035399683,-0.019526167,-0.014547439,0.08296878,-8.111493e-05,-0.03276766,0.000121178935,0.06326487,0.018413108,0.0033791028,-0.03836759,-0.0017213289,0.044038124,-0.009758043,0.03810477,0.042240042,0.031534564,-0.0032889745,-0.044059206,-0.0069980007,0.14434886,0.07029999,0.06099742,0.05158294,-0.0175085,0.0074553234,0.0718276,-0.003723971,0.043144003,-0.02273498,-0.042153355,-0.053735066,0.031686388,-0.06731228,-0.05086419,-0.04899479,0.026925374,-0.0038867784,0.06098357,0.025070284,0.038582597,-0.01974217,0.03516386,-0.029663566,-0.01173826,-0.017739989,-0.09903606,-0.008373772,0.09004079,0.04265557,-0.0044728895,0.037634667,0.025555467,-0.0136503205,-0.013791902,0.019523108,0.017215747,-0.003593193,-0.058589984,-0.015649805,0.07300865,0.04951092,0.042744845,0.041566003,-0.0065318034,0.025190853,0.05237257,0.08105362,-0.016928662,0.08550131,0.06474925,-0.09380014,0.001876662,-0.027755713,0.009467729,-0.018509265,-0.011290241,0.059372883,-0.036638748,-0.001181152,-0.08137303,0.0001532884,-0.059234373,0.0848556,0.08034294,-0.032177333,0.033075318,0.0059521594,0.058848605,-0.059415516,0.079378664,0.092224434,-4.4418243e-08,0.06328146,-0.0672491,0.044027984,-0.07478212,-0.045485355,-0.016526856,0.040622525,0.011553729,0.06688646,-0.03317036,-0.011125402,-0.00010146302,0.03237203,0.039624367,0.019728992,0.12964946,-0.0115389265,0.032675367,0.0094789425,-0.044788282,-0.05882876,0.023910342,-0.08176716,0.0074703293,0.039227515,-0.027370362,-0.010962374,0.1246895,0.03498173,0.01117835,0.041269436,-0.0043571177,-0.020274285,-0.08003782,-0.040556982,0.09865706,-0.045665868,-0.060976624,-0.05928648,-0.024104612,-0.012557603,0.01798754,0.00015861705,-0.014643771,0.039796643,0.057829015,-0.042506702,0.06182725,-0.04173426,-0.045004535,0.080021866,0.025055377,-0.05441145,-0.06910424,-0.15201774,0.040827267,-0.049150832,-0.015141352,0.00831273,-0.08257258,-0.050209623,0.0033502607,0.11268488,-0.07042825 +4.1.1.65,The enzyme contains a tightly-bound pyruvoyl cofactor.,384,1.0,-0.037100393,-0.052048784,-0.12512775,-0.09142045,0.061090354,0.022309188,-0.09871915,0.05111024,-0.030745743,-0.025544908,0.051438704,-0.023924561,-0.11446404,0.076343656,0.007989284,0.02828356,-0.07209118,-0.068930835,0.049096968,-0.03321073,0.0325606,0.0484901,0.029646859,0.008209013,0.0004728116,0.052215744,0.04293667,-0.0051209284,0.041612018,-0.04666747,-0.03734373,-0.018809522,-0.0703879,-0.044818725,0.12006639,0.06408951,-0.093528375,-0.024946202,0.045439266,0.020398721,0.11501613,0.028285246,-0.017699283,-0.000120782366,-0.04058384,0.008823219,0.08575121,0.0067787142,0.019788798,0.021035984,-0.06725305,-0.018358322,-0.031019254,0.009325413,-0.028909652,0.0032713134,0.022355724,-0.03275428,-0.05123035,-0.019730944,0.012558525,-0.0091524515,-0.017186435,0.02760215,0.012019025,-0.034543276,0.035436388,-0.046320304,0.0046278206,-0.002002334,-0.046482038,-0.04874133,-0.05218221,0.057628673,0.024247473,0.035860464,-0.016967347,-0.0971979,0.06818796,0.007629762,0.0114877885,0.016479865,0.04497781,0.088773645,0.042180553,-0.004682813,0.07059574,-0.019009927,0.009265,-0.038102027,0.03016341,-0.08356262,-0.01735991,-0.006787663,-0.006087911,0.029007474,0.01738512,0.06713881,-0.058499295,-0.07752573,-0.014504924,-0.025658395,-0.024309011,-0.03571514,-0.08241263,0.03912173,0.005020424,0.055876955,0.10337294,0.053903323,-0.025249887,0.051010184,0.054944668,-0.01456278,-0.0010498089,0.054117728,0.053587843,0.009318096,-0.010464854,0.05722319,0.02556771,-0.020658571,0.043842338,0.08321906,-0.06453556,0.00027125017,-0.14007178,-3.9082372e-34,0.05260195,0.04740535,0.014547199,-0.036342118,-0.0138592785,-0.016856238,-0.11170251,-0.015731731,-0.12047311,0.013787155,-0.07150566,-0.032495216,0.016330706,0.052824087,-0.058972046,-0.06487874,-0.043476753,0.037452277,0.04653368,-0.04630064,0.04958392,0.08165024,-0.031757995,0.084572434,-0.0020747622,0.022237975,-0.03373692,0.076352276,0.0050421953,-0.009346163,0.004464132,-0.08225707,-0.07885613,0.05429428,0.04235407,-0.028280625,-0.08688068,-0.117865145,-0.025112947,0.00023342295,-0.018870853,-0.01027326,0.020093871,-0.02363864,0.03892006,-0.15037368,-0.06888467,0.06113124,-0.017638246,0.049073298,0.037828285,-0.01338221,0.047832772,0.011329155,-0.1028411,-0.0013559267,0.012589355,-0.029991597,0.05481024,-0.01192161,0.0001990253,0.04327127,-0.019697616,0.03164786,0.027174968,0.033622783,0.0027470624,-0.047219656,0.042466294,0.10359176,-0.08895832,0.006380797,-0.022069575,0.023259249,0.022350712,-0.024291776,-0.006330576,0.0069830553,0.029437104,0.013364616,-0.016179547,-0.06294365,0.044985298,-0.017990801,-0.117219895,-0.08379935,-0.054905016,-0.0369935,-0.008925305,0.008218552,0.026210168,-0.058696583,0.009083452,0.046566717,-0.026445163,-6.1666815e-34,0.077765256,-0.108635545,0.067433864,-0.05618777,-0.041528657,0.043011818,0.08964489,-0.030889306,0.051487107,-0.02588418,0.04331495,-0.032860424,0.0034284368,-0.031846795,0.08811093,0.06933645,0.013051306,0.0741266,0.06382022,0.0022207105,0.009288704,0.025217155,-0.0075805513,0.055572554,0.015403299,0.028946713,-0.022386152,0.0023818018,0.025962224,0.0009819443,-0.065868765,-0.025098054,-0.076782726,-0.06410056,-0.06375856,0.014530618,-0.06222047,-0.012552973,0.017693307,-0.017362844,0.054274995,0.07175493,-0.016009113,0.0592886,0.009877478,0.019102296,-0.029379554,0.01338739,0.011090069,-0.023210475,0.00027441193,0.07623928,0.004063696,-0.0070463656,0.06323472,0.05443163,0.021308709,-0.015357304,-0.002224443,-0.027225103,-0.029458055,-0.045996,0.0028027853,0.041744303,0.0331512,0.113824956,0.031145277,0.014236601,0.018244801,0.034088317,0.092062436,0.06522446,0.045442842,0.07087584,-0.07339105,-0.0048379423,-0.025425177,-0.015356212,0.053896446,-0.021179374,0.011012627,-0.012452612,-0.0015495089,-0.07674485,0.024194885,-0.052828472,-0.0004832118,0.070498034,0.06331263,0.046559013,0.03864736,-0.04245673,0.038089313,0.042914134,0.06186979,-2.2652355e-08,0.07392988,-0.019539915,0.09094272,-0.039417185,0.030590627,0.03559686,0.029208016,-0.06969622,0.036466543,0.00564452,0.029601848,0.03724219,-6.7013257e-06,-0.007361713,0.02737842,0.03895846,-0.08607114,0.023294892,-0.019095946,-0.03406624,-0.099736504,0.011084534,-0.094075054,0.046421207,-0.0014964455,-0.022197954,-0.018382333,0.08354329,-0.017788628,0.019228563,-0.025567207,0.013316877,-0.0067984224,-0.1002448,-0.094212204,0.04697128,-0.028083093,-0.03229294,-0.055232316,0.06005152,0.0076977857,-0.019404594,0.030001538,-0.0017544961,0.0058802315,0.06644388,-0.010569172,-0.029479919,-0.023161119,0.04328192,0.092856936,0.021759922,-0.02857733,-0.025652325,-0.15858552,0.015064956,-0.000670058,-0.09649136,-0.017769158,-0.12602004,0.010221161,0.004536537,0.21955194,-0.029777663 +4.1.1.68,"Requires Mg2+ [2,3]. Part of the 4-hydroxyphenylacetate degradation pathway in Escherichia coli. ",384,1.0,-0.017300293,-0.094975695,0.055554643,0.013676036,0.022732522,-0.01616053,-0.029590067,-0.007903028,-0.018547544,-0.04211346,-0.007648786,0.010202907,0.05925257,0.057764407,-0.016181123,-0.0046528857,-0.029709851,0.09320024,-0.03745515,-0.002593924,0.11737781,0.012261425,0.008742038,0.024635885,0.012142745,0.03346804,0.11070608,-0.047986798,-0.012594506,0.0006436354,0.022438396,0.03230329,0.012261493,-0.11182733,0.0889658,0.10015503,0.060034454,-0.0723866,0.07631836,-0.049973775,0.0032964263,0.009575536,0.09444607,-0.034069072,0.0069027147,-0.04704469,0.05529545,-0.03988944,0.059711672,-0.039872605,-0.043910336,0.012846726,-0.03925592,0.032862015,0.088718355,-0.015794815,-0.07167031,-0.058767214,-0.043718368,0.06596734,0.041797686,-0.008967587,-0.015967343,-0.028685858,-0.010950536,-0.016922388,0.06708092,-0.03566034,0.02348365,-0.0026075358,-0.07368795,-0.026192352,0.010378029,-0.005864191,-0.061053153,0.039390184,0.048336852,-0.12635534,0.036485154,-0.0050995992,0.016027546,-0.05414271,0.09173437,0.07209138,0.016426528,-0.051956672,0.046899725,-0.02008873,0.044826064,0.122797556,0.037188135,0.052707184,0.081447855,0.009545057,0.019715054,0.01766981,-0.020349605,-0.02657105,0.038755007,0.035435762,-0.056661844,0.057626475,0.0025363932,0.008903157,-0.04552561,-0.017407069,0.012867774,0.13243088,-0.0024352258,0.033543725,0.071765915,-0.009867331,0.014442109,0.08569065,-0.022996273,0.07833162,-0.006872302,-0.104088925,-0.05109123,-0.028189585,-0.03672614,-0.022427248,0.029697968,0.03872092,-0.08166241,0.025256278,-0.02648059,1.1298188e-33,0.014802147,0.009526422,0.0677699,0.009316665,-0.031478938,0.03338633,-0.06642608,-0.051247723,0.023300333,-0.099407725,-0.036239527,-0.07840136,-0.047887433,0.021221293,-0.0131358635,-0.08713687,-0.06720332,0.063328184,0.105170496,0.0071085542,-0.03724669,0.058643933,0.016481243,-0.062411934,0.010160412,0.070232086,0.004565573,-0.03513376,0.02779707,0.01959075,0.018706407,-0.07953618,-0.080349974,0.023336314,0.06521349,-0.05964641,-0.027533388,-0.0538293,-0.01239076,0.038455382,-0.096808,0.041652802,-0.018089207,-0.020430101,0.046542015,-0.058603328,0.019653222,0.033642538,-0.04783702,0.08337313,0.057915427,0.03148646,0.028465714,-0.023746243,-0.07807204,-0.012934061,-0.014198116,-0.005507277,0.06851057,-0.030928105,0.03445406,0.09262098,0.02578119,0.02558673,0.1075921,0.0007346403,-0.048987247,-0.06344796,-0.014514201,0.093719915,-0.022319298,-0.078328215,0.064603284,0.031080965,0.05448888,-0.05911035,-0.0702018,0.056288138,0.05189965,0.0037529832,0.0049150847,0.004852078,-0.042998984,-0.007280688,-0.009425492,0.050659504,0.030359294,-0.043209717,0.02723058,0.08122884,0.05856807,-0.07384876,0.0030939751,0.075666204,-0.021386433,-2.0743932e-33,0.045238383,-0.03636543,0.041171245,-0.037666447,-0.1511196,-0.015887981,0.033091724,0.0028618032,0.04447077,-0.0054339473,0.08796728,0.016472034,-0.014100983,-0.07476562,-0.00059053337,-0.06503985,0.026319537,-0.03705043,-0.074508175,-0.02357696,0.08817019,0.047735143,-0.01876089,0.040016536,0.039176,0.035560355,0.06404513,0.02905113,0.036135364,0.08882532,-0.03151784,0.060382914,-0.020620782,-0.024922153,-0.09289612,0.041720245,-0.025905631,0.0035029128,0.001633145,-0.008960182,0.011279923,0.05757596,0.005197828,0.08296321,-0.01061138,0.062816344,0.011105073,0.079410456,0.058646165,-0.098084584,-0.04789719,-0.060485817,-0.07013476,-0.06844091,-0.01226306,-0.029354505,-0.019731823,-0.0028232734,-0.014926392,-0.033463474,-0.0420932,-0.028425097,0.11224959,-0.050513096,0.011489746,0.037081603,0.016556213,0.040713813,0.032896042,0.026748646,0.058312908,0.029930867,0.07286051,0.01837125,0.058049954,-0.009708983,-0.08974416,-0.02783764,0.003526527,-0.046107933,0.031837534,0.0281935,-0.0572983,-0.061777916,0.038058847,-0.14157526,-0.0059252684,0.12214714,0.0256336,-0.029399652,-0.024113571,-0.03895689,-0.07764413,0.0035448794,-0.008876258,-2.7028994e-08,-0.04562663,-0.07305439,0.03472349,-0.064651996,-0.009384716,0.07462826,-0.052041985,0.024641303,0.1147142,-0.051087525,0.025925582,0.026272036,-0.044422302,-0.0022998608,-0.03368211,-0.020755762,-0.08117594,-0.03476345,-0.028034858,-0.049214862,-0.084654205,-0.074434854,-0.10235395,0.03681222,0.019760767,-0.054989733,0.011130785,0.040981207,-0.03827354,-0.0677709,0.05943487,-0.010985522,-0.011237871,0.0097976355,-0.036991086,0.00018710249,-0.041542165,0.013027553,0.0016110918,-0.01458059,-0.06810003,0.013977215,-0.02071684,0.0093103545,-0.009659815,0.054303378,-0.055368356,0.06374781,-0.08221953,0.0014018121,0.05961452,-0.0746156,-0.041977443,-0.019116946,-0.056932025,-0.04465406,0.04406026,-0.053632993,-0.048801254,-0.08028305,0.020801125,-0.023384321,0.08085626,-0.04038216 +4.1.1.70,"The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.",384,0.99999994,-0.062320653,-0.061407693,-0.07643233,-0.026286656,0.07976374,0.06685139,-0.05114914,-0.019940814,-0.004295162,0.009032931,0.02055301,-0.017144755,-0.036398828,0.030994477,-0.058142684,-0.056489665,-0.090794176,0.00613326,0.028646708,-0.004141349,0.10986568,0.05946963,-0.009187318,-0.022616932,0.04776693,-0.043697543,0.049899153,-0.039786246,-0.0050263763,-0.06134877,-0.037964728,-0.047671404,-0.015674122,-0.0022648198,-0.023690095,0.055289514,-0.091976315,-0.05806797,0.10037043,0.04822522,0.003063743,0.021681903,0.05123299,-0.048932664,-0.009799659,-0.068193026,-0.02113455,-0.043447495,0.11360652,-0.017521726,-0.027207768,-0.003141569,-0.039169032,-0.0022558097,0.0015441421,0.012782255,-0.06996642,-0.039022688,-0.020546833,-0.0050590094,0.07772526,0.060040664,0.0025542807,0.0041425116,0.057881303,-0.07190147,-0.0055430206,-0.0062244134,0.06201263,-0.030872492,-0.0841575,-0.048121706,0.08157549,-0.022068085,0.050985765,0.0009077228,-0.008875452,-0.0045673964,-0.03571798,0.018605985,0.033634357,-0.007998879,-0.041556276,0.0760824,0.008900849,-0.050042234,0.014156071,0.0011656424,0.013886159,0.027058866,0.05433019,-0.017306,0.05307814,-0.025854796,-0.050385892,-0.09268915,-0.017442249,0.025480125,-0.0452858,-0.004156126,0.008295435,0.07245902,0.01522343,-0.05409289,-0.027585547,-0.036418438,0.008394506,0.06843298,0.02725591,0.05538602,0.04157129,0.05317551,0.025992706,0.010858815,-0.02544165,0.070369035,-0.028326554,-0.13736223,-0.05571032,-0.047885906,0.030686865,-0.03636481,0.041181594,0.032681495,-0.007787281,0.06286018,-0.11134721,1.8320667e-33,0.0585315,-0.021562992,0.002909347,0.0017310086,0.014071312,0.028529523,-0.1175258,-0.034019645,0.029372182,-0.08411764,-0.10197341,0.006704527,0.03690388,0.002538509,-0.07778623,-0.022008874,-0.056029815,-0.0711425,0.037667755,0.0585664,0.027615879,0.0795948,-0.0027380635,0.049847633,0.029833352,0.03941826,-0.018814344,0.015922766,0.038468342,0.009353107,-0.001688689,-0.101349086,-0.07938643,0.07362853,0.093321934,0.021360053,0.0107344175,-0.048848752,0.06170689,0.05997641,0.017370638,0.03967136,0.016912099,-0.0071547455,0.039634787,-0.033053547,-0.027847847,0.11818505,-0.026501173,0.077674724,0.024707658,-0.05107691,0.021081725,-0.029826475,-0.08791402,0.042149067,-0.08632231,-0.030679384,-0.006460691,0.09033069,0.04979648,-0.02173266,0.033312514,0.014021902,-0.0028719474,0.04457958,-0.09828285,-0.045963414,0.08890884,0.040778924,-0.05305423,-0.030781647,0.070758775,0.105859004,0.062261462,-0.02152071,-0.100922495,0.0062760822,0.04581111,-0.012066234,0.009372969,-0.0190487,-0.039058335,0.018072208,-0.0028831174,-0.011626632,-0.019462159,0.007787358,0.033699308,0.0039040179,-0.0154973855,-0.049062993,0.013890236,0.007269029,0.006952792,-2.9633652e-33,0.12590028,-0.10846952,0.017518563,-0.005125303,-0.011467633,0.0010353873,0.083889246,-0.04210083,-0.04766497,-0.05204936,0.054992355,-0.028976431,0.07783168,-0.015490772,0.06363114,0.018311383,-0.054578714,0.027843336,-0.027114032,0.0013416511,-0.0016845393,0.010390035,0.037033446,-0.032271475,0.052175544,0.012265398,-0.07571358,0.101095766,0.017550843,-0.017813362,-0.021230591,0.06223723,-0.09231776,-0.12535405,-0.11784582,0.08686584,-0.03840109,-0.028826639,0.015622454,0.030790528,0.072707884,0.016021185,-0.030092685,0.053790797,0.08105642,-0.00091608777,-0.04864732,-0.024808545,0.036739264,-0.059374478,0.024662614,-0.031834967,0.048981324,-0.048492108,-0.0017451387,0.090547636,0.025611693,0.090023205,0.009993202,0.043175057,0.023064781,-0.0643774,-0.0013993203,-0.07515135,0.013703882,-0.037028797,0.03977535,0.071661025,0.06902886,-0.075821556,0.10269906,0.04004449,0.085283235,0.004662666,-0.03082602,-0.08729142,-0.08303725,-0.034932256,0.053672466,-0.0618858,-0.049910963,0.012083081,0.007708794,-0.039706856,0.026696961,0.02197106,0.03879783,0.033626255,-0.017197445,0.0060986616,-0.040217053,-0.040418856,-0.057323355,0.043433536,-0.006417729,-4.2063572e-08,0.06916997,-0.05126265,0.011097957,-0.0478238,0.0150567535,0.08843232,-0.050855443,-0.006644097,-0.005696681,-0.041610267,0.047617417,0.0936511,-0.09248019,0.084990345,-0.028965982,0.076213434,-0.029382013,0.0787899,-0.047885865,0.021062495,-0.098398186,0.02379766,-0.15669136,0.100238174,0.0018825734,0.002953136,0.030622393,0.067562215,-0.016894482,-0.05693925,-0.050253496,0.025169503,0.037566558,-0.05695874,-0.07002923,-0.008044133,-0.02800642,0.016214106,-0.00013461456,-0.016568327,0.023719063,0.0074667423,-0.042938996,0.0055938037,-0.0054057925,0.0024386784,0.0058452347,0.07334387,-0.025024364,0.031196354,0.07084909,-0.03887959,-0.0039298544,-0.037927166,0.002971761,-0.05608286,-0.04069165,-0.06424859,0.010790015,0.048734244,-0.049544275,0.021166267,0.14044201,-0.04360451 +4.1.1.71,Requires thiamine diphosphate. Highly specific.,384,0.99999994,-0.03021411,-0.03816108,-0.03806552,-0.020957144,0.02502725,-0.05921531,0.028013268,0.057292517,-0.03778134,0.014467296,0.014749836,-0.059295606,-0.03969555,0.114082314,-0.011231521,-0.006932587,0.06804783,-0.0572708,0.037716407,-0.014713126,0.05541563,0.106308445,-0.0040851175,-0.018953608,-0.041504912,0.060439967,0.033660103,-0.022988118,0.028858334,-0.049905974,-0.08508313,0.044294916,0.032135833,-0.07632759,0.011198812,0.085867904,-0.09481977,-0.011465306,-0.0024674977,0.020494916,0.098145284,-0.05046794,0.053705804,-0.015545239,-0.03595497,-0.016192077,0.058927633,0.033634312,0.040125426,0.033591524,-0.04972412,0.017662372,0.019958414,-0.0035582632,-0.016560474,-0.10235592,-0.04883279,0.023406463,-0.02388494,0.012046589,-0.044342,-0.061024874,-0.05224558,-0.040512476,0.14125192,-0.0320827,-0.0021672093,-0.026598271,0.035870053,-0.013684577,-0.027327035,-0.0135600595,0.008980551,0.047391824,-0.037057266,0.061293945,0.046808224,-0.06833548,0.08787943,0.0012038902,-0.06630915,0.0024246846,0.0090242345,0.087680556,0.1275921,0.055520277,-0.0061016898,0.00048576892,-0.06587379,0.009023638,0.019044802,0.021494878,-0.02089179,0.002447186,-0.06557617,0.06147723,0.022018667,-0.029113533,-0.07677717,0.0005494544,0.0052156663,0.0071924725,-0.07416219,0.019149788,-0.031019812,-0.035977144,0.00820054,-0.003070942,-0.005527387,0.019169591,-0.003946473,0.028281381,0.05466741,-0.0083618825,-0.048342332,0.04262613,0.0262934,-0.053039074,-0.023974048,-0.011283149,-0.034215238,-0.030401994,-0.0032484,0.0116597265,-0.060911033,-0.013590626,-0.022645367,6.3170626e-34,0.075615086,0.07735771,0.063135654,-0.013351764,-0.053947203,0.05291359,-0.09165787,-0.015890867,0.016177122,-0.035818454,-0.0005809758,-0.07942143,0.015883397,-0.01910895,-0.01434704,-0.06826836,-0.008955914,-0.004271451,0.109899476,-0.04364871,-0.006692324,0.021546204,-0.08303156,0.029183801,-0.029257169,0.048842587,0.03357097,0.025209865,0.010851166,-0.0036473088,0.10787663,-0.025903767,-0.05403654,-0.038514894,0.024145884,-0.0030641917,-0.07112146,0.004466399,-0.055226956,0.004723447,0.04973836,0.06264924,0.008551362,0.020657822,0.08665352,-0.11851976,-0.049724557,0.084565006,-0.034962643,0.056739338,0.0034706695,-0.01089045,0.086753584,-0.04853041,-0.015827427,-0.014425734,0.01894656,-0.044417296,0.04827739,0.04941388,-0.019539062,0.03614928,-0.07655195,0.07720577,-0.029186128,0.02219399,-0.105616055,-0.036326613,-0.020686375,-0.00044753065,0.028461497,-0.04393453,0.08847183,0.0020656604,-0.067767866,-0.056287173,-0.022095613,0.038140237,0.021223433,-0.04202477,0.056180134,-0.07501115,0.039143752,0.009603835,-0.08923045,-0.061949678,-0.003121611,0.009026458,0.015349234,-0.016640153,0.08279367,-0.0785145,-0.044387765,-0.03252964,0.012816289,-1.4648163e-33,0.08333889,-0.07185764,0.06963078,-0.034293853,0.029178962,-0.0061214743,0.0611273,-0.08953955,0.034388017,-0.039236415,0.061826684,-0.0060640117,-0.0043861144,-0.0040149777,-0.030355396,0.12018455,-0.026400521,0.08173204,0.025696788,-0.029343193,-0.0474675,0.10740115,0.04656846,0.10838052,0.015916958,0.031387858,-0.02119365,-0.005572935,-0.04344376,0.05447314,-0.054793883,0.028198304,-0.11541996,-0.042605914,-0.08470502,-0.054227415,0.013794958,-0.038934782,-0.06114302,0.0141867725,0.0046625985,0.06369323,0.05478316,0.120188534,-0.009809496,0.06008491,0.029943839,-0.04102785,-0.022937717,0.012609565,0.042539146,-0.02831686,-0.05690197,0.009594596,0.04333064,0.013502124,0.028916504,0.0020905754,-0.015736395,-0.03828092,0.054806527,-0.04133147,-0.020530993,-0.0747091,0.036915205,0.04688524,-0.00044457804,0.09277963,0.11572814,-0.0029252144,0.09870598,0.08255215,0.1307393,-0.08310993,-0.057117887,0.01355758,-0.03183002,0.043483,-0.0063043996,-0.03340035,-0.00992957,-0.020005723,-0.06995212,-0.017967097,0.042303223,-0.060959224,0.046040267,-0.03591127,-0.04318839,0.05786983,-0.09091154,-0.032546952,-0.0049712565,0.10838488,0.07654193,-1.891884e-08,-0.0001884579,-0.02528034,-0.0003575095,-0.031185118,-0.028087905,0.05841552,0.055424564,-0.024649892,0.080502816,-0.033290144,0.001325156,0.06214797,0.07467373,0.04941911,0.1405603,-0.0715702,-0.014054624,0.04967258,-0.08402514,-0.03686959,-0.09695889,-0.031465374,-0.018955028,0.029393684,0.022328455,-0.01014067,0.045953363,-0.002305521,0.038430188,-0.019978508,-0.01059331,0.00050309347,-0.025879055,-0.09445575,-0.0629556,0.07917923,0.050571773,-0.008537077,-0.039119203,-0.020975659,-0.075799845,0.019408684,-0.09978434,0.052146602,0.017706182,-0.0397269,-0.023094725,0.08859807,-0.025710646,-0.02686615,0.011628691,-0.0034233788,0.012012012,-0.058286544,-0.06536003,0.029626189,-0.017639212,-0.022686863,-0.027825365,-0.052125987,0.09853872,0.044235814,0.114120804,-0.029199438 +4.1.1.72,"Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.",384,1.0,-0.0041026967,-0.09653709,-0.03700582,0.015919609,0.070289254,0.03381463,-0.10328323,0.007528438,0.06178989,-0.064048275,0.049716473,-0.058711674,-0.018639268,0.029725676,0.020488616,0.08578389,-0.07953505,-0.028148962,-0.04727137,-0.0470566,0.07887939,0.033838566,-0.038918007,-0.00016152061,-0.034767352,-0.051134598,0.025320021,0.039724734,-0.008741202,-0.066775754,0.05200216,-0.008139847,0.02141861,-0.057290595,-0.014050545,0.025529275,0.046635184,-0.04021322,0.07094956,0.029896209,0.053140167,-0.0331929,0.023704495,-0.019927746,0.017613132,-0.015627952,0.037704244,0.07422768,-0.030708587,-0.0010253477,-0.045646418,-0.078539416,-0.05897151,0.028918382,0.020710407,0.011133844,-0.039467014,0.005955278,-0.040457267,-0.017680153,0.04009741,-0.0031941114,-0.0022190807,0.0633127,-0.026092188,-0.0945522,0.041986987,-0.08253053,0.0013623283,-0.019959781,-0.09047614,-0.106804155,0.007049955,-0.0012268601,0.07425172,-0.03420657,-0.07088944,-0.09091645,0.045624558,-0.064189605,0.0012303297,-0.02379843,-0.013469986,0.07776849,-0.0071382504,-0.09448238,0.03330123,-0.023373317,-0.03653282,0.07034759,-0.0011129375,-0.060310397,0.011212146,-0.02469816,-0.040558547,0.018913994,0.06330836,0.041594625,0.035789814,0.00054697593,-0.053609487,0.018720519,-0.012942987,-0.089126885,-0.030844925,-0.008286082,-0.04544973,0.063651234,-7.853159e-06,0.010180074,0.043493472,-0.029353742,0.034165923,0.013583714,-0.02432453,0.037990343,0.078062706,-0.09718548,-0.1082846,0.0019234406,-0.028900094,-0.047875233,0.0428497,0.05144384,-0.028079286,-0.0027397573,-0.09404742,-2.2917339e-33,0.057604402,-0.05591418,-0.005831913,-0.018417822,0.0677258,-0.07943866,-0.09272392,-0.019790735,-0.000660966,0.03490531,-0.019539688,-0.028049443,0.057864107,0.08853828,0.04731158,-0.028064046,0.008818413,0.0039996007,0.059987683,0.047529723,-0.038394086,0.0830258,0.0062892623,-0.051239442,0.025367104,0.048794586,-0.043030817,-0.045463726,-0.0001272158,-0.0033212716,0.027005441,-0.059780672,-0.10598561,0.005818891,0.07441209,-0.005366832,-0.050284367,-0.03476608,0.005074382,-0.025378026,0.059022587,0.009995236,0.0041313334,-0.03422921,0.008403055,0.019964928,-0.049318943,0.09203923,0.048772674,0.070151344,0.053614944,-0.037345063,0.07362667,-0.012346886,-0.040312603,0.0040631997,-0.08035937,0.02013822,0.020177774,0.021474449,-0.04134172,0.03612843,-0.06941311,0.028817054,-0.06919495,-0.03208014,-0.04142163,-0.0323728,0.01929444,0.041611962,-0.004245179,-0.007927756,0.042741537,-0.011163797,-0.020151004,0.02276174,-0.082668714,-0.025412643,0.058146857,0.017897634,-0.027157405,-0.017642895,0.038753435,-0.031292867,-0.07258725,-0.018002668,-0.051137585,0.00960767,-0.030302757,0.06500613,-0.060447462,-0.005069445,-0.02386061,0.03345735,0.11615631,-1.7015745e-33,0.07333826,-0.13810444,0.056585006,-0.08790741,0.008691631,0.015250315,-0.049465965,-0.025591178,0.010605503,-0.00038504336,0.049763132,0.04792463,0.012490881,0.016263632,0.016613565,-0.032762118,0.006687495,0.09842712,0.03143912,-0.07393038,0.08198964,0.004943071,0.016191674,0.085402414,0.050749112,0.048883803,-0.028743122,0.018754724,0.059047475,0.09642298,-0.03901748,-0.020536441,0.015769958,-0.043999292,0.0081251785,0.08528876,-0.060309887,0.024957588,-0.0052901455,0.05375682,0.039921362,0.0028493316,0.02570415,0.01600057,0.06020705,0.04318492,-0.042442225,0.027306898,-1.5601894e-05,-0.09924636,0.050878488,0.016183594,0.003927561,0.024789495,0.028601442,0.11111596,-0.016990546,0.009959855,0.08493668,-0.11629203,-0.12477668,-0.07885458,-0.01911938,-0.07478704,-0.035502065,0.02585595,-0.017324196,-0.053084124,0.009406723,0.014043238,0.06671174,0.07804847,-0.006844749,0.02479039,-0.038810536,-0.08443239,-0.074420415,-0.12073967,-0.010387596,0.018587263,-0.037836224,0.01833985,0.03085189,-0.021700492,-0.0069311047,-0.07204183,0.028969117,0.09067498,-0.013331089,-0.00091290206,0.020395407,0.005619123,-0.06371384,0.046296954,-0.013202512,-3.561354e-08,-0.020246906,-0.059977308,0.098395735,-0.006396386,-0.046522595,0.017278383,0.06516523,0.070463195,0.037012514,-0.051508173,0.0710056,0.12635414,0.01822817,0.05912566,0.089677915,-0.0050430084,-0.07044668,0.00012153397,-0.033239927,-0.05522006,-0.07475442,-0.046800714,-0.025861999,0.073657125,-0.016948888,-0.0760876,-0.014283826,0.025998967,0.0017009376,0.0025611094,0.059184283,0.07088339,-0.03421036,-0.023035498,-0.046485316,-0.000479007,-0.057929274,-0.053650867,-0.033798322,0.039836615,0.017696865,-0.03521406,-0.07161368,0.022727093,0.09027052,0.026905391,-0.044579882,0.06993304,-0.040760417,0.019851299,0.057695013,0.0020372467,0.016841898,0.030625427,-0.10268903,-0.036778547,0.0054212627,-0.0858643,0.026565414,-0.006903995,0.0534338,0.06754667,0.22252369,-0.017036453 +4.1.1.74,Thiamine diphosphate- and Mg2+-dependent. More specific than EC 4.1.1.1 pyruvate decarboxylase,384,1.0,-0.03319015,0.010248819,-0.008027091,-0.025702242,0.040527366,-0.00872944,-0.039066665,0.008988119,-0.051608086,0.053752895,-0.0159589,-0.039019786,-0.023011535,0.019620504,0.0030751806,-0.026868472,0.010251344,-0.0597894,0.037338316,0.010931514,0.07516526,0.05825053,-0.028976748,-0.018476203,0.029935159,0.0073887315,0.080174096,-0.03823848,0.005667899,-0.051886495,-0.06655305,-0.004868853,0.078482375,-0.058402237,0.04225888,0.14117144,-0.06746195,-0.0077692624,-0.0065285694,0.014065409,0.061159026,0.06601973,0.07964626,0.0054371436,-0.084199294,-0.03354812,0.11943141,0.0043198685,-0.025803108,0.034757003,0.019426266,0.06648529,-0.032191873,0.011661909,0.02673137,-0.06850846,-0.047753233,0.022235148,-0.11882167,-0.010011486,0.01654639,-0.01881293,-0.008355908,-0.09199215,0.063814,0.0016855239,0.07482666,-0.05367736,0.052278534,-0.06098365,-0.10969294,-0.010524771,0.072821006,-0.06648211,-0.060203385,0.048822273,0.015300456,-0.05456138,0.025760768,0.013111104,0.0026390012,-0.023342378,-0.016385976,-0.042287055,0.0022029753,-0.053507816,-0.004502445,0.013306034,0.011535649,0.046354998,0.0943877,0.014620292,0.05291263,0.05044363,-0.038069893,0.034664385,0.023848886,0.03153139,0.017685814,-0.055065643,0.051711746,0.084691465,-0.09638246,0.0076105776,0.003874563,-0.0074502868,0.03256515,0.010834041,0.007606002,0.074696906,0.020580653,0.033770725,0.04111785,0.08292634,-0.01636766,0.06847539,0.008853109,-0.06671001,-0.006666191,-0.0056359926,0.03600084,-0.004333686,0.07367592,0.036315527,-0.085554436,0.03046812,-0.1119869,2.1166853e-33,0.009722964,-0.00122629,0.05990463,-0.0129831815,-0.019370578,0.036054716,-0.113092184,0.051486697,-0.008826584,-0.014340906,-0.061514214,-0.026360445,0.09528526,-0.014981408,-0.09599173,-0.12903818,-0.08461564,0.0152547425,0.10588297,-0.043211896,-0.05683408,0.09255704,-0.046848204,0.052998062,0.008119057,0.060858157,0.031392995,0.07027421,0.011190254,-0.022512002,0.07846263,-0.13891692,-0.053161908,-0.0564497,0.039877243,-0.038034976,-0.06238796,-0.0034373088,-0.074046746,0.00875153,-0.04088543,-0.007320498,0.014271844,-0.050682638,-0.018258568,-0.13496293,-0.022496337,0.060041543,-0.022016106,0.016342405,-0.0072982335,-0.017174078,0.052419502,-0.032686923,-0.016094944,-0.021785539,-0.014335911,0.036623202,0.09203148,0.030079957,0.06341814,0.043290805,-0.040145636,-0.01996893,0.007894245,0.027933113,-0.11270892,-0.072831936,-0.014725707,0.074756816,0.0057157506,-0.06248056,0.11288927,-0.021684827,0.011580452,-0.007419249,-0.081387125,0.087287076,-0.019122463,-0.0057194284,0.038842745,0.020438476,0.0090099,-0.028252857,-0.10378286,-0.017124064,0.041225687,0.011144849,0.037157115,0.06470885,-0.016319908,0.013287258,-0.005848044,0.006429032,0.04149796,-2.0689373e-33,0.07452331,-0.06120295,0.012659877,-0.055271626,0.009766917,-0.0028278306,0.10325098,-0.03915903,-0.009390874,-0.063357025,0.071588054,-0.01814302,0.015819319,-0.027964147,0.049632914,0.047056086,-0.022369534,0.056356613,0.015279005,0.014679777,-0.023537224,0.082489744,-0.0154018,0.0078995805,-0.014310308,0.017390953,0.06644258,0.04925577,0.00086288893,0.055166464,-0.015771717,0.08879844,-0.06399852,-0.013655429,-0.13288271,-0.029099138,-0.06691955,-0.05663843,-0.02389445,0.06814805,0.013520496,0.085794926,0.053458028,0.07528201,0.091957204,0.014618603,-0.0150935715,0.020266658,0.036759194,-0.015654862,-0.0072700344,0.017726075,-0.059650704,-0.049554024,0.10846642,0.01905824,-0.038952917,0.004455676,0.06798825,-0.030869355,-0.041433048,-0.087660804,0.06844379,-0.07706676,0.008027473,0.016282398,0.003064009,0.0087947855,0.11506859,0.053775147,0.09045606,0.026624257,0.008604524,-0.07377567,-0.024844311,0.031422235,-0.050280694,0.015672285,-0.009611673,-0.06768492,-0.011017604,-0.008425842,0.0074665225,-0.059222676,-0.001998271,-0.0747951,0.007936026,0.059557006,-0.023970574,0.014578976,-0.07949531,-0.12639582,-0.033555094,0.088171884,0.07156204,-2.6727797e-08,0.006029767,-0.039287377,-0.0059383605,0.03283814,0.00061313476,0.069555014,0.0116245225,-0.0033986985,0.0843103,-0.019112058,0.08540217,-0.015335431,0.012871776,0.037030876,0.07913121,0.02299288,-0.09650182,0.044660714,-0.006236694,0.03794056,-0.024924899,-0.04477738,-0.08857584,0.02909091,0.025296062,0.014696638,0.022697754,0.004875023,-0.024756882,-0.06533928,-0.008535343,0.03665694,0.06842641,-0.09533521,-0.021780321,-0.008528964,0.0064171026,0.031142259,-0.035627328,0.031153342,-0.021692004,-0.09909527,-0.05217885,0.039956674,-0.010040788,0.011711151,0.0230735,0.06824382,-0.06341477,-0.050883144,0.018546574,0.0005753773,-0.03933952,-0.0059298696,0.040865257,0.022109393,-0.054617446,-0.027231464,-0.03751408,-0.024251781,0.060409784,0.03159868,0.03344527,-0.10333962 +4.1.1.75,Enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation.,384,1.0,0.012249278,-0.0956705,-0.03161688,0.0015346064,-0.0060843565,0.017629605,0.020536417,0.019462971,-0.0121326605,0.03856022,-0.0033832823,-0.021726362,0.019268528,0.09611971,-0.008709199,-0.00094372785,-0.027041465,-0.04529116,0.0010365583,0.007947268,0.06653107,0.042807706,-0.076073766,-0.02233362,0.0040550292,0.032794494,0.09459379,-0.07379553,-0.054328375,-0.05533553,-0.16003115,0.012337691,0.06961968,-0.031833306,0.0166293,0.08710043,-0.066186346,0.0065482943,-0.02261672,-0.009870514,0.057895258,-0.0033759933,-0.018924817,-0.022879133,-0.08271795,-0.058348063,0.09608553,-0.017876875,0.0046694693,0.043905847,-0.07864674,-0.031488527,0.022670954,-0.00080281374,-0.006785,-0.04490178,0.018707503,0.026565274,-0.09487786,0.021774394,-0.0376817,-0.03323084,-0.006264633,-0.024727147,0.16486104,-0.080059774,0.04467903,0.02050552,-0.008381302,-0.06537514,-0.059307378,-0.026371678,0.012547846,-0.07730644,-0.0059371553,0.0026761193,0.034090154,-0.02991365,0.053328786,-0.025403563,0.0185862,-0.03973152,0.0050239074,0.046164997,0.048976365,0.009857153,0.035227045,0.026734477,0.06486593,0.029222345,0.05850546,0.01988605,-0.03560554,-0.025112368,-0.11274346,0.0036590183,-0.023235524,-0.013852894,-0.021784494,-0.018696994,0.06553799,0.027043303,-0.07046448,0.009034119,0.006346426,0.037235692,0.022109518,0.0112394625,-0.0032537812,0.064489625,0.046590634,0.039649025,0.061605256,0.04479325,-0.034421925,0.07395945,0.06708581,-0.07135472,-0.08198274,-0.025561303,-0.00029631064,-0.008930656,0.09643382,0.052579094,-0.065546624,0.020808049,-0.07192344,-1.1231834e-33,0.058773577,0.009858037,-0.00408785,-0.0683417,0.020205626,0.010720154,-0.020096349,0.06487555,-0.017530393,-0.025139088,-0.04174658,-0.048877563,0.0820857,-0.036123097,-0.0011137777,-0.037637614,0.023874195,0.03349044,0.09974872,0.0038462104,-0.025055641,-0.015483543,-0.061857693,0.07250353,-0.00034474983,0.019993326,-0.013723087,0.09813215,-0.0344938,-0.032175917,0.11974029,-0.14064045,-0.09323686,-0.03333047,0.090888746,-0.043252584,-0.037054908,0.05748534,-0.050385498,-0.041229602,0.003408084,0.010559085,-0.0060704816,-0.030971287,-0.0050450726,-0.08849268,-0.041655168,0.109378174,-0.012071241,0.021242164,0.029854732,-0.052637577,0.13626687,-0.09300897,-0.06516064,0.028473455,-0.008237316,-0.018042602,0.062017635,0.055769198,-0.0025462848,0.0057919556,-0.066120714,0.05412994,-0.045332577,0.036190894,-0.083134085,-0.036911048,0.060141135,0.10708355,-0.018971268,0.020613637,0.047602236,-0.0004729049,-0.008487105,-0.024954865,-0.056848638,0.004337341,0.015966997,0.018843172,0.08401806,-0.05865778,0.018214189,-0.029039975,-0.10868497,-0.042042393,0.03601476,-0.05862002,-0.03638072,0.028834555,0.075749405,-0.008202357,-0.06716821,-0.037812777,0.0972965,-9.427862e-34,0.098200545,-0.0836316,0.03858283,-0.082189135,-0.054216184,0.024038175,0.055801187,0.0016566414,-0.014873678,-0.031926822,0.034220755,0.013948913,-0.01645397,-0.01981354,-0.030148856,0.06890862,-0.05769103,0.08741516,0.08663683,0.010221516,-0.08807029,0.07411468,-0.0011830666,0.044170804,-0.0003767119,0.019565908,-0.00907359,0.0415614,-0.005377538,0.042995635,0.007743963,-0.004916132,-0.040544745,-0.045666024,-0.064825356,0.025347024,-0.017521169,-0.049112342,0.032970704,0.06627228,-0.04366751,0.07021032,0.06707351,0.060129005,0.009155846,0.035343073,-0.03888113,-0.024092853,-0.07068041,-0.07307556,0.049695265,0.022090247,0.0048831534,0.0037754024,0.061676566,0.03935317,0.020896249,-0.0019843366,0.00667022,-0.028041704,-0.0015624819,-0.083673395,-0.024137905,-0.030861733,-0.03799359,0.00898263,-0.031043619,0.03698077,0.099995896,-0.007695157,0.044437632,0.06458903,0.05346402,-0.036577694,-0.08425984,0.05437572,-0.008377244,0.019597381,0.0036761086,-0.037865415,-0.0036194983,0.03614143,-0.033573996,-0.09082656,-0.078809805,-0.04259401,0.04033122,0.09335903,-0.022622475,0.04437346,-0.066909425,-0.042939376,-0.028661847,0.030003995,0.114281915,-2.5994591e-08,0.034659944,-0.048377547,0.0036162906,-0.016149256,0.019270623,0.039778627,0.009569919,-0.031395055,0.09981583,0.032274794,-0.025605882,0.048468314,0.00332942,0.060898647,0.086506695,-0.018060911,-0.038956046,-0.030610492,-0.077012815,0.029801123,-0.055795632,0.026664933,-0.11488431,0.03245864,0.051700458,-0.028982533,-0.048338667,-0.008657131,-0.06535125,-0.024163604,0.02292756,0.029362893,0.008546018,-0.09227444,-0.06382895,0.034863036,0.07492778,-0.06917314,-0.052283484,0.0374293,0.0007399205,-0.06820647,-0.09055106,0.01880588,-0.01897316,0.010832743,0.029466052,0.031671286,0.013514887,-0.043419246,0.021504983,0.026412925,-0.041743983,-0.02841304,-0.014466929,0.035873916,-0.016863646,-0.027635233,-0.04345977,-0.022178214,0.11271169,0.022121452,0.12209688,-0.111543044 +4.1.1.77,"Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enzyme has been reported to accept multiple tautomeric forms [1-4]. However, careful analysis of the stability of the different tautomers, as well as characterization of the enzyme that produces its substrate, EC 5.3.2.6, 2-hydroxymuconate tautomerase, showed that the actual substrate for the enzyme is (3E)-2-oxohex-3-enedioate [4].",384,1.0,0.022333631,-0.07687211,-0.021472769,-0.06843491,0.04386508,0.046053402,-0.06527768,0.047092106,0.03289238,0.02630321,-0.012169392,0.0061812773,-0.12210754,-0.017804347,-0.017329786,0.09375602,-0.090628214,0.042312797,-0.034765672,-0.038364407,0.062381487,-0.022631207,0.10438855,0.033274945,0.014465209,0.048643846,0.027093768,0.0072682737,-0.067112945,-0.05670341,0.0147863375,-0.048778057,-0.029404588,-0.021327738,0.03143615,0.046243798,0.013715765,-0.12094392,0.0739075,0.039042126,-0.0007013681,-0.048518583,-0.11921975,-0.015438815,-0.020320224,-0.01511558,-0.031102331,0.050582495,0.08750859,-0.02745807,-0.10192539,0.0055430806,-0.025098886,0.022767095,-0.05571528,0.11501818,0.019707454,0.08228443,-0.07719372,0.057513688,0.019200766,-0.050642375,-0.0040971525,0.013114505,-0.04252818,0.08205226,-0.0041603167,-0.068867,0.054498322,0.032373074,-0.06632417,-0.11741205,-0.04372325,0.0017756459,-0.0118633825,0.08995993,0.07345009,-0.01934231,-0.007708181,-0.030516883,-0.021519454,0.012837479,0.08297692,0.0044452273,0.005075935,-0.017997311,0.012012618,-0.043693632,0.11421987,0.058740743,0.05294684,0.002669478,0.05718871,0.016207421,-0.033716537,0.08002195,-0.0012063495,0.014733859,0.017675394,-0.016021313,0.029442323,0.015337491,-0.008469155,-0.06857658,0.020683955,0.10731818,0.04720805,0.05987476,-0.03022898,-0.009081151,-0.033874966,-0.060086858,0.055365875,-0.044531073,-0.032661773,0.07026656,0.029026115,0.0064920974,-0.033249166,-0.040027156,0.052735012,-0.07287393,0.04905793,0.042653006,-0.066173084,-0.0020166545,-0.03918475,2.2648634e-33,0.055549927,0.016601248,0.03375302,-0.005158323,-0.037832573,0.037646607,-0.06738388,0.08275225,-0.03330088,-0.06309924,-0.056558236,-0.10035555,-0.04660799,-0.07071504,0.014624283,-0.05032974,-0.046592686,0.06057854,0.06731149,0.017862966,0.018277407,-0.0026325814,0.0032225067,0.01590437,-0.08799669,0.018360734,0.047262754,0.010451998,-0.06742196,-0.036213133,0.043187626,-0.12864687,-0.06056567,-0.0061227744,-0.08640352,-0.00491447,-0.05103231,-0.011593799,0.060635015,0.11528862,-0.02413549,0.023811981,0.082084276,-0.0069001867,0.025308136,-0.019669008,-0.0048335074,0.05063271,0.043044895,0.013508922,-0.027450334,-0.05557406,0.09846586,0.06619014,0.021932645,0.017160501,-0.025729528,0.0031619454,0.022876844,0.0042150375,-0.02140202,0.03400448,0.030020645,0.06653133,-0.010182106,0.024325976,-0.04495705,-0.022957847,-0.008712374,0.06454682,-0.051492687,0.055135507,0.058123015,0.016744131,0.060339026,-0.09899746,-0.057439722,-0.04659804,0.05711234,0.026652798,0.008183963,0.034921564,-0.054254115,0.08970153,-0.043234788,0.046760093,-0.036335614,-0.04659328,0.030346321,0.09943885,-0.018561628,-0.049978532,-0.02587057,0.031518225,0.00043587733,-1.049197e-33,0.09064282,-0.010989594,0.00429554,-0.006222572,-0.07064664,0.030725015,-0.022820203,0.03758284,-0.020496124,0.0076428065,0.038618654,-0.0040823407,0.03178928,-0.106122166,-0.041480448,0.032198798,-0.03498926,-0.008136078,-0.03289346,0.015246617,0.03581709,0.010448512,0.008547779,0.019652694,0.033728965,-0.01135063,0.017185679,-0.010450858,0.12895522,0.0067433706,0.017819272,0.06725076,-0.0041681216,0.037682354,0.057807032,0.07343915,-0.01351575,-0.005031475,0.017136548,-0.0034966832,0.012327138,0.043611836,-0.00791349,-0.060665682,0.010802235,0.088363536,-0.10424495,0.009779034,-0.055463776,-0.054086167,-0.026782919,0.022640644,-0.0780357,0.043987148,0.057366733,0.082961805,-0.039162226,-0.037127506,-0.019532971,0.022279238,0.0003502627,-0.016675599,0.080449834,-0.022210028,0.07884154,0.026995143,-0.04676871,0.14729628,-0.008499564,-0.021116512,0.07641691,-0.07192774,0.0189888,0.039089877,0.017851062,-0.023557708,-0.043858856,-0.026558055,-0.029975008,-0.017882397,0.091033876,-0.028350247,-0.018316884,-0.09576661,-0.04443075,-0.034976847,0.05272291,0.088208556,-0.047417343,0.11553517,0.06401257,-0.06365063,-0.03866764,0.09369271,0.05681888,-4.144511e-08,0.01503469,-0.005976553,-0.005108042,0.0196263,-0.01662742,0.010159192,0.0031382092,-0.0067797042,0.06700951,-0.045440793,-0.025970291,-0.011046212,0.011909857,0.05224488,-0.006736811,0.016516501,-0.11172349,0.0022980818,-0.00010974893,0.07700122,-0.06985604,-0.022766942,-0.15389362,-0.028463567,0.043977335,-0.025903983,-0.034266554,0.07473408,-0.019275371,0.0112197455,-0.00048576324,0.019646494,0.07407691,0.013889144,0.016814398,0.0035580546,-0.084959276,-0.029973451,-0.07170489,0.046313837,-0.07277343,-0.081377305,-0.020879649,0.02482002,0.05292822,-0.018760227,0.001225278,0.05309381,-0.004807329,-0.009800125,0.057333346,-0.029495806,0.01217657,-0.074946836,-0.10856801,0.045687456,0.024134554,0.0030499105,-0.034505684,-0.11010752,0.008683843,-0.02193762,0.08991988,-0.049551252 +4.1.1.78,"The mechanism appears to involve hydration of the acetylene and decarboxylation of the oxaloacetic acid formed, although free oxaloacetate is not an intermediate. It is thus analogous to EC 4.2.1.27 (acetylenecarboxylate hydratase) in its mechanism.",384,1.0,-0.07787772,0.033155914,-0.040989425,0.05452641,0.07357136,0.0016818086,-0.06423516,-0.011979359,0.05062164,-0.042833544,0.020417996,-0.03634611,-0.052113093,-0.057145413,-0.05520624,0.005314326,-0.096589416,-0.020581761,0.014255814,0.015014303,0.06696503,-0.0764458,0.020762878,-4.7152516e-05,0.01483429,0.06834326,0.1087523,-0.030656995,-0.0059716725,-0.1329204,0.018041136,-0.015173573,-0.0029055597,-0.009529638,-0.045086674,0.03480813,-0.006994286,-0.06360012,0.012451114,0.07438057,0.019206015,-0.0012864271,-0.0013279219,-0.02810036,0.029547734,0.002315798,-0.0016527176,0.014517669,-0.034503225,-0.022561535,0.031630963,-0.044620626,0.0058724713,-0.011347626,-0.018362822,0.018643752,-0.0037391272,0.009743189,-0.03813725,-0.020767016,0.12564936,0.0012436991,-0.024653468,-0.012704897,0.0034863711,-0.030594988,0.02910155,-0.044286896,0.027087139,-0.036606602,-0.039823674,-0.044026908,0.030208278,0.013928825,0.041398026,-0.017979799,-0.0399126,-0.041638445,0.08010857,0.052204516,0.034827568,0.004043344,-0.007792926,0.046769056,0.051959727,-0.0134545,0.019203393,-0.0862822,-0.012861614,0.03845476,-0.04033502,0.007646972,-0.07165709,-0.035896264,-0.033690505,-0.016151726,0.046497427,0.09460828,0.0044642785,-0.011673713,0.018328067,0.13733,-0.053704586,-0.095247574,0.053057726,-0.045175288,0.03221539,0.107568204,0.04009651,0.033365704,-0.0049370094,-0.10054892,0.05695999,0.020736529,-0.06791497,0.14954908,-0.11398687,-0.048054732,-0.07620871,-0.0068374416,0.026048956,-0.06521645,-0.020801269,-0.0021331625,-0.019850964,0.010547184,-0.11552538,3.2178335e-33,0.057783123,-0.026355712,0.009250574,-0.0053959303,0.020931998,-0.007829516,-0.10433964,-0.025460677,-0.0619996,-0.041031294,-0.009717357,-0.0278804,0.045611765,0.027349906,-0.06655482,-0.11279754,-0.07511364,0.012844052,0.009037482,-0.026617134,0.04314936,0.062140625,-0.035666674,0.030911617,-0.08183171,0.037546843,-0.017529413,-0.02375134,0.040806554,0.021249017,-0.041703206,-0.025902338,-0.05432523,0.043491196,0.00407493,-0.022499107,-0.011730229,-0.077941015,0.025453893,0.07897473,0.05518156,0.0015376551,0.031791326,-0.050413176,-0.019907657,-0.07252021,-0.027329138,0.108076625,0.046051238,-0.0008473224,0.022598235,-0.0012168299,0.07655075,0.016410908,0.00846797,-0.026992911,-0.11110693,-0.05550104,0.0009752331,0.010743886,0.018868707,0.031308666,-0.044396117,0.035024833,-0.064614125,0.08576865,-0.08715241,-0.023347553,-0.017887501,0.013095835,-0.008310255,-0.017183024,0.041488342,0.023924174,-0.0013008381,0.004443503,-0.0337751,0.018089224,-0.016541993,-0.008077374,-0.020244723,-0.0057749804,0.08444917,0.03444608,-0.0061311224,-0.015225422,-0.00849871,-0.0013449839,0.07341909,0.051920526,-0.0041602026,-0.09216259,-0.0728546,-0.0071790116,0.106025994,-4.6924614e-33,0.12608984,-0.07420088,0.0060084765,-0.09923387,0.03778299,0.07377968,-0.002121178,-0.0070971027,0.034578066,-0.017555105,0.064758085,0.030282816,0.03889906,-0.051432405,0.0701193,-0.040654484,0.027350565,0.00019326253,-0.021939127,-0.016853197,0.048912026,0.0008222713,0.0038957954,0.009810406,0.026933711,0.008019166,-0.013129649,0.0019028161,0.03936686,0.07760416,-0.031873625,-0.021990297,-0.020395799,0.0021026377,-0.073557355,0.061334334,-0.06814257,0.0066971635,-0.043394126,0.012043747,-0.041364975,-0.063755564,0.034301132,0.06491265,0.11905871,0.022995824,-0.06596454,-0.010382897,-0.03605299,-0.07089658,0.049963143,0.008817712,-0.019031953,0.030968212,-0.019486135,0.09040406,-0.020968672,0.0165602,0.041777983,0.025587993,-0.01839027,-0.015023903,0.036246665,-0.0861372,0.0089282,0.01563633,-0.01670822,0.074204534,0.06360752,-0.028854491,0.12951198,0.03899835,-0.0037888053,0.08132282,0.051628135,-0.05492097,-0.09939335,-0.08218194,-0.013150015,-0.08232279,-0.10210509,0.008513477,0.03135272,-0.070907235,-0.026255248,-0.07083699,-0.020464553,0.077084064,-0.07480683,0.029956114,-0.015123823,-0.07717243,-0.06779298,0.09650201,0.028466817,-4.0715435e-08,-0.041601002,0.0127374055,0.113544546,0.058496512,0.0024762908,0.06960835,0.09015416,0.07064516,0.04325234,-0.13243893,-0.0014693235,0.08703381,0.10429679,0.0037081449,0.044676226,0.031435467,0.0059733368,0.028851148,-0.06952698,-0.06276441,-0.049652938,-0.05191272,-0.022597222,0.032912318,-0.047193646,0.0016029892,0.07588032,0.079912536,-0.046113513,-0.058576018,-0.031883866,0.025106598,0.032655127,-0.055158693,-0.016577605,0.07212333,-0.007303373,0.010213791,-0.015488577,-0.045556575,0.010860754,-0.030082446,-0.077926904,0.056061033,0.051136993,0.049683347,-0.008290835,0.04539332,-0.01645814,0.01986494,0.035322823,-0.013034688,-0.016337782,0.0128874825,-0.055782158,-0.02059503,-0.022487547,-0.04478848,0.04466385,0.008382274,-0.008292318,0.016230414,0.1962061,0.00041980844 +4.1.1.79,Requires thiamine diphosphate. Does not decarboxylate pyruvate or phosphonopyruvate. The enzyme appears to be oxygen-sensitive. ,384,1.0,-0.032771915,-0.0046696137,-0.0665182,-0.020128822,0.009276333,-0.030317046,-0.027738929,0.011960179,-0.025943382,0.053480532,-0.025871586,-0.047665436,-0.08670698,0.09067117,-0.02727009,0.01734232,0.04094546,-0.05609567,0.05906878,-0.028649796,0.09308416,0.10561403,0.017583301,-0.03761657,0.036789473,-0.008420158,0.037952825,-0.019369617,0.036196943,-0.025467932,-0.07801422,-0.019374592,0.048213188,-0.06491531,0.025191486,0.17846328,-0.07768635,-0.030523255,-0.0058843745,0.019138478,0.06670918,0.012018976,-0.0054654065,0.024666404,-0.058752034,-0.016671902,2.8812497e-05,0.013704598,-0.01955212,0.04279053,-0.03179735,0.02979974,-0.024689717,-0.0042006928,-0.041148182,-0.027986746,-0.03630433,0.021727305,-0.0875866,-0.050271463,-0.05108556,-0.024461986,-0.020315118,-0.03888489,0.069749124,-0.019866941,0.02505787,-0.05287193,-0.0155664515,-0.053121824,-0.03522702,-0.04873432,0.07562292,0.027055804,-0.098502144,0.012052095,0.034703553,-0.045703027,0.07841273,0.01667752,-0.0056443,-0.035231564,-0.033067185,0.038450584,0.056722812,0.044629425,-0.03066757,0.013194367,-0.05931876,0.04110233,0.032251794,0.016807772,-0.022924766,-0.010170027,-0.019139528,0.012489011,0.043672387,0.032917578,-0.049095247,-0.052334644,0.035056494,0.04779019,-0.0548605,-0.019131307,-0.06414594,-0.006477913,-0.0039749285,-0.027976453,0.011371331,0.049044296,0.0077753384,0.054457057,0.06401808,0.032841116,-0.006719631,0.07733688,-0.026192952,-0.050390057,-0.03860791,0.03454324,0.011813668,-0.04013699,0.00500294,-0.007203648,-0.09007888,0.004111702,-0.066859655,3.9297316e-33,0.054347675,0.011017741,0.022769112,-0.02281147,-0.025410797,0.07353094,-0.11459465,0.019295255,-0.045546085,-0.033227816,-0.031388465,-0.094614044,0.083840884,-0.017272847,-0.044114478,-0.03912927,0.005146586,-0.002244229,0.077940285,-0.06296375,0.043200485,0.028053673,-0.045291137,0.04727568,-0.036195494,0.057308674,0.007944166,0.07002827,0.023482205,-0.023338098,0.054416243,-0.13646497,-0.043395206,-0.054374058,0.0486337,-0.00031596198,-0.061210215,-0.020372692,-0.073907636,0.00093555707,0.03561246,0.029806243,-0.0067210128,0.008570888,0.043171603,-0.09466802,0.00011675846,0.09428727,-0.022754567,0.066159956,0.04921612,-0.0066873347,0.053146992,-0.053670835,-0.005953409,0.03056121,0.01328761,-0.017762464,0.06901079,0.0069921776,0.025080787,-0.034516,-0.025763128,0.0124276895,-0.010159379,0.021708895,-0.12677854,-0.05851999,-0.053432528,0.07904253,-0.027280217,-0.05777826,0.064297475,0.0059731593,-0.004730066,-0.045467928,-0.024948882,0.08481114,0.013047632,-0.07414733,0.08973321,-0.04037746,0.027210768,-0.0049683554,-0.07320779,-0.040236875,-0.010279864,0.041903235,-0.023944277,0.046836745,0.059637964,-0.079073094,-0.027298117,-0.007991376,0.02189771,-5.0759176e-33,0.07414455,-0.08450679,0.04160135,-0.07677974,0.035174843,0.07068887,0.061555803,-0.09920368,0.041256253,-0.09865665,0.06087526,-0.030589452,-0.005172118,0.014669906,0.04150774,0.1176351,-0.00814924,0.05305163,0.030521795,-0.0122865345,-0.02094017,0.14355467,-0.017929303,0.048161864,0.018869573,0.024757186,-0.017439207,0.02435189,0.006074307,0.053162158,-0.03603423,0.027786909,-0.09188734,-0.032496464,-0.09025187,-0.0010418518,-0.059930075,-0.0673713,-0.049612556,0.03939212,0.005913704,0.10613231,0.03144564,0.113031685,0.022743702,0.014295095,-0.028236713,-0.063712336,-0.0032044507,0.009645022,0.018922621,0.011619662,-0.08827588,-0.004695088,0.08508009,0.061154116,-0.031034566,-0.018058391,0.0054461975,-0.048240032,-0.00095903955,-0.07008859,0.02408531,-0.052065376,0.035583083,0.036786057,0.011102263,0.065575615,0.10242798,5.2742165e-05,0.08017771,0.09966211,0.023519818,-0.01787231,-0.047048643,0.029647896,-0.070738755,0.056909733,0.022954741,-0.055927593,-0.026250932,0.015930442,-0.023527678,-0.031500842,0.023704696,-0.09540569,0.03430872,0.036313985,-0.03762453,0.04766242,-0.034711555,-0.069120124,0.0006506413,0.09063179,0.1318764,-3.122382e-08,0.004779812,-0.03734618,0.017255643,-0.03577099,-0.04926716,0.028308686,0.07647634,-0.04938547,0.03405096,-0.05575742,0.026162032,0.02125899,0.025336083,0.07011773,0.12449934,-0.039600212,-0.04603677,0.091450885,-0.04409488,-0.024801731,-0.07458461,-0.044689238,-0.072747216,0.068701625,0.027653974,0.0052510058,0.042050894,0.030516667,0.021448757,-0.033854946,-0.026647314,0.06203706,0.040467672,-0.12966017,-0.10252012,0.039574757,0.06179853,0.0063233445,-0.035917867,0.016629057,-0.035262734,-0.02815181,-0.046012852,0.050976276,-0.015185132,0.009161744,0.050400246,0.038096156,-0.036996942,-0.008186661,0.0446545,-0.010137291,-0.027782556,-0.04985618,-0.04075831,0.008174184,-0.057191603,-0.03379488,-0.028345896,-0.054320417,0.07372899,0.04421405,0.15640563,-0.10195969 +4.1.1.80,Reacts with dopamine to give the benzylisoquinoline alkaloid skeleton.,384,1.0,-0.050558828,0.0020283107,0.056466267,0.0030742988,-0.092743136,0.027299406,-0.061579723,0.06972943,0.0817025,-0.025167173,-0.02252254,-0.05127603,0.03765274,0.03642102,-0.057785496,0.11630684,-0.021420874,0.044980213,0.005782834,0.015229854,-0.062211093,0.057748333,0.04516342,0.022782505,0.041234013,0.047651306,-0.020387502,0.0030394471,0.014489325,0.028729402,0.06676758,-0.023936475,-0.012144778,-0.003504911,-0.031403646,0.011229143,-0.12592517,-0.0010444553,0.03590734,0.109879024,0.01896814,-0.0022136976,-0.065131076,0.060719777,-0.0100882,-0.036662865,0.013405105,0.023973465,0.010345321,0.047916833,-0.0109030185,-0.030215275,-0.029940043,0.09731204,-0.050581153,0.05279334,0.004786739,0.12711565,-0.026161782,0.073652215,-0.011765453,0.05773401,-0.0004685341,-0.008135483,0.04814446,0.061884947,-0.07437756,-0.038793314,0.0702221,-0.06505962,2.028937e-05,-0.08557198,0.062038302,-0.08270113,-0.02500613,0.0028315422,-0.019837564,0.005997149,-0.015733832,-0.078659534,-0.021672754,-0.015359067,-0.009814575,0.02928368,-0.03624787,-0.006970211,0.008795191,0.055284914,0.024202945,0.029607324,-0.020740638,-0.046886273,-0.111825384,-0.055682767,-0.0388451,0.016281778,0.023754649,0.08444386,-0.01694941,0.05767707,0.08598806,-0.01872392,-0.08196929,-0.04913408,-0.057270918,0.018054092,0.01331049,-0.08097093,-0.05401681,-0.074713275,0.05897725,-0.01516871,0.023118276,0.027830862,-0.025850791,0.03563026,0.014431387,-0.0006006406,-0.06035174,0.03558047,-0.0077154683,0.003913455,0.05708724,-0.036731828,-0.037735082,-0.049796835,-0.03502929,3.5778926e-34,0.056252573,0.025320565,-0.016030202,0.017247459,0.027453493,0.012841295,-0.067032814,0.005895419,-0.06590714,-0.008156343,-0.08080365,0.0057741557,0.012185623,0.03987787,-0.01995511,0.033151474,-0.08326182,-0.0015950089,0.059977088,-0.11976144,0.031238643,0.023682857,-0.02765855,0.035037372,-0.01902073,0.07068106,-0.09000958,0.03463209,-0.1008025,-0.013706118,-0.06516486,-0.04680575,-0.07864806,-0.013158409,-0.10649874,0.08201097,-0.049325246,-0.0025498345,-0.08216764,-0.0131403385,0.09971699,0.056237392,-0.028787028,0.024663338,0.049853336,0.029768521,-0.037964538,0.030792933,0.030694185,0.05899475,0.015077727,-0.060919486,0.06400679,0.051750265,-0.12854819,0.022363806,-0.021593764,-0.0640837,0.0067375824,0.04138676,0.021790331,0.030757207,0.01366445,0.0066722226,0.018948987,-0.0356433,-0.0032560148,0.017359331,-0.05794822,0.008644631,-0.012042274,0.0030181687,0.03242265,0.017658679,-0.073269255,-0.047260266,-0.027139613,-0.06579349,-0.04056055,-0.04376498,0.0016566806,-0.11791285,0.036413074,0.013676302,-0.027576666,0.043014575,0.049810253,-0.08909786,-0.029096954,0.047836654,-0.047850788,-0.055319633,-0.030987158,-0.0015141738,0.050761264,-1.8044174e-33,0.035135724,-0.08221625,0.036648795,-0.04037141,0.022521215,0.039920393,-0.04536809,0.013047474,-0.035670422,0.07639026,0.035065487,-0.028684674,0.005171681,0.04106189,0.008318647,-0.09322576,0.029433217,0.08528995,0.045258135,-0.019881362,-0.025718134,0.051264003,-0.116309054,0.043923974,0.024284558,0.040746015,0.090138815,-0.08011831,0.011517706,0.11927381,-0.012933965,0.06940726,-0.06457546,-0.031262297,0.097928405,0.119290315,-0.019748174,-0.010758502,-0.04670842,0.008777007,-0.009973219,0.03573312,0.030992625,0.071874775,0.04589263,0.036404926,-0.046238903,-0.036661636,-0.088335134,-0.011706541,0.11125675,-0.00072021526,-0.0076519866,-0.04759044,0.015417825,0.046808183,-0.027917469,-0.1007715,0.05316872,-0.0906905,-0.042313695,-0.028915767,-0.0411868,-0.029011386,-0.015687939,0.040633496,0.014950523,0.07293056,0.010393329,-0.0039741453,0.06430103,0.0065735173,0.050025437,0.110869445,-0.023104487,-0.0003348714,0.05460286,-0.040156662,0.08541561,-0.122020215,-0.00589756,-0.024054727,0.069007516,-0.019770166,0.014418266,-0.0020560194,-0.0631589,0.1247134,-0.037624467,0.030159645,0.027082399,0.06007223,-0.017873319,-0.025567912,0.055143934,-2.1686189e-08,0.07791627,-0.013341516,0.014344404,0.037551735,-0.03872753,0.008316552,0.06104157,0.05447103,-0.037544634,-0.05643801,0.018686697,0.00051460107,-0.008496173,0.08942038,0.019939108,0.06848012,-0.05522353,0.03690495,-0.046541706,0.01386371,-0.087370284,0.023213059,0.05020358,-0.055800308,0.050445326,-0.0956706,-0.05558538,0.093024135,-0.033127062,0.015883854,0.093324274,0.0049065314,-0.0463501,-0.02811966,0.01800013,0.007347557,0.041529506,-0.033717293,-0.0028667327,-0.0491859,-0.054994285,-0.06162528,-0.008499461,-0.009453259,0.021096608,-0.055944946,0.030283932,0.012279671,0.079668045,-0.020362336,0.0034951868,0.047471408,0.033577543,-0.05455458,-0.070648335,-0.028783942,0.010539989,0.00022930265,-0.010837748,-0.13775307,0.036210604,0.0064563085,0.080506355,-0.08827106 +4.1.1.81,"A pyridoxal-phosphate protein. This enzyme is unable to decarboxylate the D-isomer of threonine O-3-phosphate. The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of EC 6.3.1.10, adenosylcobinamide-phosphate synthase, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway.",384,1.0,-0.08062516,-0.0047030724,-0.10835494,-0.12600206,-0.013057116,0.0008954663,-0.03513531,-0.00040810235,0.05892326,0.050099242,0.011550326,-0.049242787,-0.048754018,0.0020708921,-0.015782632,-0.023447959,-0.03135107,0.032412402,0.018728357,-0.07497868,0.0739503,0.091313824,0.011669462,0.015575266,0.060281474,0.02085928,0.059865877,0.0591639,-0.0051078093,-0.028003708,-0.044764873,-0.047590956,0.08013709,-0.042032715,0.048582867,0.16610155,-0.03045509,-0.006235526,0.03749835,0.010906041,0.0629333,-0.02114945,-0.0013933247,0.0027388572,-0.016562419,0.011312926,0.020289924,0.06579212,0.057101376,-0.063250296,-0.0647837,-0.03404527,-0.07340215,-0.05169938,-0.009811373,-0.0048420983,0.028864624,0.007758262,-0.04771206,-0.018033754,0.026008079,-0.049645096,0.02821268,0.027509628,0.091641344,-0.040514614,0.036369257,-0.06374051,0.008484414,-0.04730198,-0.05506919,-0.061621036,0.05364438,0.0011604917,-0.031716745,0.06258046,-0.056325242,-0.029754186,-0.025934853,-0.017306205,0.05224414,-0.019676754,-0.0034006762,0.042916156,0.043738727,-0.025337627,-0.031275798,-0.008332551,0.04711164,0.02059918,-0.02564204,0.022876743,0.08260924,-0.0018387291,-0.046650108,0.027948849,-0.016804198,0.034421507,-0.024174225,-0.03407967,-0.006186602,0.099790834,-0.06204425,-0.038499374,-0.013120504,-0.007816144,-0.034993567,0.110616915,-0.01575022,0.030744758,-0.06882493,0.02771868,0.0010260831,0.03842775,-0.016474275,0.07529052,0.0270495,-0.018927252,-0.07361337,0.029590439,0.000345499,-0.04754739,0.006707344,0.068138614,-0.023749374,-0.030364288,-0.039193235,4.3683607e-33,0.08507777,0.08893896,0.05157786,-0.0032238178,0.022084944,-0.005905183,-0.10661787,0.0049118027,-0.041564997,-0.051853556,-0.0194055,-0.07370516,0.07547859,0.02213076,-0.06318734,-0.064651966,-0.09421172,0.09614774,0.06772829,0.006608235,0.043668777,0.030456139,-0.035371054,0.07933138,-0.022484971,0.067631125,-0.0104849385,0.07467146,0.01644327,-0.0031513239,-0.015628766,-0.0835155,-0.08901902,-0.061927725,-0.01076066,-0.095561214,-0.10139154,-0.02227654,-0.018256273,0.094838604,-0.05021587,-0.03606041,-0.040628392,-0.0053902576,0.021022908,-0.06542528,0.025653107,0.10314124,0.0089892205,0.08182039,0.023177382,-0.032282602,0.096005216,-0.02943732,-0.067766964,-0.025089657,-0.026176333,-0.0151129365,0.023207549,0.072385475,0.076502874,0.041904904,-0.02894583,0.038587943,-0.053999774,-0.04869563,-0.04806335,-0.08999442,0.051222324,0.09595495,0.02947724,-0.04138747,0.05416043,0.07243218,-0.015365883,-0.057499234,-0.07497272,-0.012920597,-0.03483892,-0.05998936,-0.00868398,0.007270429,-0.039725628,-0.053311504,-0.074766904,0.039422534,0.024207933,-0.027498541,-0.008857853,0.019466331,0.009129435,-0.054215506,-0.045139514,0.040000148,0.027801307,-3.775164e-33,0.10563283,-0.041333336,0.06840388,-0.07045973,-0.046277177,-0.001686098,0.0650118,0.013180693,0.06748141,-0.005191527,0.049350012,-0.042140637,0.038813006,-0.031277716,-0.0191169,-0.0047531365,0.01532367,0.041738722,-0.0089809345,0.012609571,0.01746102,0.008266825,0.0042012525,0.019129992,0.016262809,0.08006645,0.019112369,0.060386833,0.0034691573,0.09138281,-0.031379875,0.05596264,-0.047836382,-0.010207006,-0.062185783,0.087695315,-0.03485537,0.0034402783,-0.037471253,0.01038254,-0.0004308548,0.09690328,0.020728733,0.013307639,0.012618822,0.06258043,0.04520612,0.050571762,-0.015640385,-0.051662065,0.042239845,0.054217793,0.008479897,0.03878543,0.060348324,0.07190987,-0.030507974,0.023411768,-0.027329413,-0.06822199,-0.03253491,-0.08430087,0.025451178,0.0046413606,0.08653753,0.031894945,0.017374998,0.08331756,0.04106338,0.08265311,0.09113908,0.02378278,0.018498782,0.024922315,-0.069916114,-0.021518512,-0.07300764,0.022573192,-0.016777458,-0.035739854,-0.044656184,-0.05397515,0.012778472,-0.030293563,-0.0513916,-0.07136839,0.049407195,0.07995634,-0.014034775,0.08483162,-0.07329836,-0.047581837,-0.029849924,0.07404681,0.085480206,-4.4028514e-08,0.091742694,-0.11550682,0.027729243,-0.018330643,0.049366884,0.050465506,-0.010376513,-0.019760549,0.089499384,-0.005900023,-0.027946578,0.02995919,0.01309862,0.012518405,0.002478414,0.056112308,-0.039663255,0.06724376,-0.005049208,-0.057396807,-0.06896387,-0.017329121,-0.1099266,-0.009844059,0.07076822,0.017663233,0.0019813343,0.034533963,-0.009043141,-0.017055228,0.020415056,-0.035683528,0.024303518,-0.0930487,-0.017577156,0.00034156902,-0.054625455,-0.008716801,-0.023786249,-0.042429276,-0.04760418,-0.03457815,-0.06675259,0.055793304,0.025998369,0.07774422,-0.022009015,0.042803656,-0.10482771,-0.042980935,0.05770796,-0.02723727,-0.011198395,-0.0687666,-0.10666169,0.032165494,-0.045793567,-0.07359149,-0.017596802,-0.020980971,-0.00707875,0.041395035,0.15939932,-0.11972234 +4.1.1.82,"The enzyme catalyses a step in the biosynthetic pathway of 2-aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Requires thiamine diphosphate and Mg2+ as cofactors. The enzyme is activated by the divalent cations Mg2+, Ca2+ and Mn2+. Pyruvate and sulfopyruvate can also act as substrates, but more slowly. This enzyme drives the reaction catalysed by EC 5.4.2.9, phosphoenolpyruvate mutase, in the thermodynamically unfavourable direction of 3-phosphonopyruvate formation [2]. It is the initial step in all of the major biosynthetic pathways of phosphonate natural products [3].",384,1.0,-0.048735753,-0.058301426,-0.020879744,-0.042979665,0.04330076,0.070099145,-0.05416834,0.015086278,0.023748947,0.11313065,-0.049835574,-0.008148883,0.07546718,0.013331356,-0.032507982,0.017383592,-0.115960255,0.008196468,0.0055414434,0.013729528,0.16285366,0.045809817,0.014090858,-0.025746133,0.07695185,0.009924598,0.02459086,-0.044467162,-0.0051339664,-0.0007520582,-0.075716615,-0.0008816425,0.078547865,-0.15686397,0.03973087,0.1625413,-0.0055890144,-0.05021618,0.06519567,-0.002331659,0.028926834,0.06841185,0.0054165926,-0.047946677,-0.051637113,-0.0059760264,0.056112383,0.036234044,0.047494926,-0.031036787,-0.08168543,-0.007849481,-0.0027878515,0.0006543917,-0.03491273,0.062370133,-0.062998086,0.009616149,-0.00044542743,-0.026989114,0.001420443,-0.024804873,0.017992053,-0.011462133,0.020099428,-0.050149344,0.04571909,-0.07286039,-0.002460985,-0.047164645,-0.087069124,-0.020209735,0.014692147,-0.034104582,0.011269671,0.028033419,0.0326833,-0.026378099,-0.026047174,0.049399562,-0.013414291,-0.058784276,0.021070125,0.006257407,-0.009216303,-0.035304822,0.0063480353,-0.022663372,0.04691022,0.054809086,0.0003593249,-0.034324627,0.033030584,-0.035378117,-0.033013243,0.059680488,-0.0049950844,0.041661404,0.10244863,-0.028284533,-0.043924466,0.038180396,-0.029447665,-0.06410933,0.04999101,-8.153116e-05,-0.020571873,0.071298,0.0018140407,-0.017859122,0.06686428,0.021769535,0.037902147,0.031853847,-0.03509964,0.09893204,0.0023109561,-0.11330876,-0.10634932,-0.012494967,0.044455457,-0.05616203,0.013430711,-0.01053784,-0.0970072,0.03618203,-0.09892868,6.1531487e-33,0.03894687,0.02345415,0.037415605,-0.05412685,0.016663799,-0.008819138,-0.105457485,0.06360659,-0.043138474,-0.031226553,-0.03845368,-0.051097833,0.0962964,0.006276131,-0.050868697,-0.020150825,0.039783664,0.0031368309,0.06903306,-0.014447872,0.019239487,0.044716444,0.017195422,0.027576622,0.037559345,0.079480335,0.0065599694,-0.04198783,0.029137462,-0.012183463,0.08109761,-0.10800639,-0.103280276,-0.028155299,0.01828227,-0.025833236,-0.09934971,-0.0437535,-0.062995404,0.028611066,-0.050932616,0.035060734,-0.02528063,0.02992501,-0.0021782282,0.018664148,-0.025819253,0.06645385,0.062895,0.114933126,0.039308906,0.046022117,0.072549075,0.0332345,-0.037734434,0.02207744,0.03200413,-0.07475077,0.009932369,0.05314927,0.01330187,-0.027635273,0.017288532,0.0032486857,-0.0016391185,0.044870038,-0.03967769,-0.047618598,0.046948753,0.043602776,-0.055105995,-0.008830561,-0.010757139,0.10762337,0.014863461,-0.014197858,-0.016031086,-0.058320306,-0.013996177,-0.017782053,0.04126792,-0.0012276857,0.0033769498,0.03262082,-0.038162824,-0.045948174,-0.06863312,-0.026185308,0.016900277,0.027158098,-0.057994578,-0.04825692,-0.007348012,0.06147255,-0.06253931,-6.973336e-33,0.14830014,-0.12503505,0.02426529,-0.12273213,-0.07923043,0.03698101,0.044367984,0.0053035147,0.0042801364,-0.016539162,0.06131792,-0.04615588,0.04801037,0.049956776,-0.05257453,0.046844993,0.097633384,0.106482126,-0.0196167,0.001313883,0.02218462,0.10450403,0.00994157,0.025629265,0.018436505,-0.003581024,-0.016017752,0.029425152,-0.04713328,0.12227825,-0.03301988,0.0071496866,-0.05961781,-0.05680554,-0.055468872,0.05355082,-0.07390344,-0.04087285,0.05860158,0.056199566,0.056724794,0.082049675,0.071176484,-0.00055139576,0.019712094,-0.01649062,-0.06756506,0.03488687,-0.03184166,-0.026511822,0.0057196748,-0.0050275526,0.039439876,-0.0060302247,0.03456581,0.023248143,-0.004222596,0.020792004,0.040090986,-0.0868795,-0.003942534,-0.083983056,0.03417997,-0.05370523,0.03245216,0.074286774,0.018619528,-0.026783124,0.019744517,-0.0087501975,-0.004632926,0.003701107,0.020494258,0.04908859,-0.028005203,0.03403431,-0.09077921,-0.07835086,-0.013655846,-0.056952823,0.037617028,0.02573296,0.023260567,-0.1091766,0.011029057,-0.02980065,0.043471392,0.0415222,0.012963105,0.00521522,-0.048773147,-0.055519138,-0.008943887,0.05786714,0.11541624,-4.639627e-08,0.020408707,-0.011029549,0.016130563,-0.013005065,-0.027230436,0.069538236,-0.03557359,-0.0778608,0.0089004785,-0.09983467,0.009013007,0.04014278,0.021050496,0.020623656,0.024530225,0.04088394,-0.07712152,0.018536666,-0.05159707,-0.048337303,-0.081960216,-0.030227248,-0.11524766,0.074809246,0.038152646,-0.032806385,0.018741312,-0.0060699405,-0.006073698,-0.032180063,0.0031628709,0.064755,-0.05364316,-0.05910984,-0.08246317,-0.015178024,-0.038217828,-0.045420542,-0.03200435,0.013804308,-0.00064764486,0.00028372373,-0.049709912,0.036175523,-0.0115122385,0.014281332,-0.0093472535,0.07908623,-0.023144003,0.019128604,0.09814246,-0.038666613,-0.018900044,-0.030984005,-0.075301036,-0.016849583,0.0053818533,-0.054697756,-0.040743567,0.0027594562,0.013620631,-0.0021034556,0.14741889,-0.10806758 +4.1.1.83,"The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product. The enzyme is a glycyl radical enzyme.",384,1.0,0.04641595,-0.023110034,-0.06414324,-0.012377117,0.03805965,-0.04023456,-0.079731286,-0.002349217,0.0041794814,-0.023876766,0.05007638,-0.063320704,-0.035303112,0.09579656,-0.027523573,0.07100851,-0.013266865,-2.3798266e-05,0.027782965,0.02451279,0.0756013,0.014889271,-0.014762867,-0.0015348182,0.009919892,-0.006506979,0.07268798,-0.018473944,-0.018665412,-0.09249012,0.036911868,-0.05161652,0.048250187,0.007604355,0.05606228,0.06373467,-0.054938287,0.008083304,0.09122219,0.02714754,0.044048,0.007365204,-0.024873676,-0.01342934,-0.0756944,-0.021271346,-0.017214943,0.02185468,0.049382195,-0.01997724,-0.041404165,-0.041978322,-0.0188264,-0.008075902,0.036108125,-0.01936669,-0.020745216,-0.025248367,0.012058482,0.048181538,0.06181652,0.0048368135,-0.071593635,-0.04469385,-0.0683343,-0.07478606,0.040433962,-0.079570025,-0.03914845,0.005917331,-0.053870764,-0.07292671,0.017896414,-0.03014398,0.025445065,0.008864173,0.008853686,-0.073158994,0.06318532,-0.06292315,-0.03052622,-0.0279613,0.041657664,0.030207481,0.11409493,0.04776911,0.025938138,-0.023286738,0.053353928,0.0043379166,0.012776058,0.052344438,-0.024151586,-0.10816165,0.014218647,0.02049408,0.013440831,0.013800661,0.0075894278,0.020415308,0.045043264,0.053471502,-0.035837017,-0.10072135,-0.102335386,-0.030919952,0.057914153,0.10277093,0.0013529792,-0.007967383,-0.036357116,0.041941788,0.06321926,-0.0017224319,-0.005651097,0.0019699484,0.051612422,-0.08887286,-0.035495225,0.0065442706,0.021325061,-0.009235063,0.08233649,0.033974458,-0.017291024,0.11198834,-0.037312154,1.946814e-33,0.07488209,0.100756265,-0.019615583,-0.03462089,-0.04925354,0.046184815,-0.08259668,0.030719982,-0.035195347,-0.06182417,-0.010729817,-0.11430003,0.02573195,0.100595936,-0.0133924065,-0.02993717,-0.024491683,0.01217469,0.06387335,0.010069706,-0.051192105,0.01623366,-0.06417933,-0.0029493654,0.027520712,0.00016647863,0.0096847145,0.04658667,0.06561616,0.012218266,0.008273126,-0.05065287,-0.03136684,-0.008810032,0.019363165,0.045973647,-0.042163506,-0.027557818,-0.04394895,0.06498403,0.049851015,0.03263463,0.04065467,-0.008794564,-0.003265274,-0.014945576,-0.035939813,0.10922859,0.026917456,0.016032824,0.038973976,-0.00855226,0.10923929,-0.13118286,-0.0732366,0.07367202,-0.0011296605,0.04019728,0.099531084,0.007457345,-0.019688327,0.09535501,-0.06443634,0.05693999,-0.011611062,-0.029999834,-0.03757888,-0.058820996,0.045100726,0.05103735,-0.016071616,-0.023197917,0.03533365,0.027348911,-0.00013570521,-0.08148561,-0.07351826,-0.021997968,0.06773394,-0.03785036,-0.037427858,-0.03200437,0.017127216,-0.044309907,-0.040388152,-0.02572956,-0.0851639,0.016001761,-0.026482623,0.003591071,0.029027939,-0.09006998,-0.052552238,-0.011083164,0.007114372,-3.343551e-33,0.09035004,-0.050235767,0.03208404,-0.06692455,-0.03161603,0.0906895,0.0009474451,-0.04216246,-0.0011906495,-0.054545823,0.07923904,-0.0016662857,0.08054034,-0.009989161,0.04311916,0.0463538,-0.007017036,0.04497919,0.0028845153,0.002826184,0.0114758825,0.055626545,0.012644098,0.07042882,0.09937689,0.027893169,-0.008573707,0.08067638,0.07160235,0.020899713,-0.03605113,0.03574666,0.049121797,-0.062373377,-0.06470768,0.093837075,-0.06368359,-0.051085897,-0.038139854,-0.03680157,-0.06405492,0.044493377,0.000112996,0.1016005,-0.030544685,0.01896273,-0.027311627,-0.012454447,0.02979176,-0.07557234,-0.039165154,-0.034056213,0.015663652,-0.029208958,0.0014194241,0.013236453,-0.021924442,-0.05544339,-0.02534303,-0.08268927,-0.14272934,-0.01958232,0.04435372,-0.03391149,0.07325105,0.047000118,-0.03949549,0.013336114,0.00201262,-0.06484666,0.010087718,0.024645573,-0.023682784,0.05076156,-0.03028613,-0.001273461,-0.070470676,0.044066668,0.002218777,0.032024674,0.052118134,-0.02930988,-0.020279229,-0.050883867,-0.0616663,-0.10152736,-0.025103342,0.06917706,-0.024513515,0.047043346,-0.033742234,-0.024479618,-0.051953148,0.088908456,0.057320897,-3.7708826e-08,0.056302253,-0.0813509,0.11549507,-0.09699376,0.0012988865,0.051811878,0.010419703,-0.047326792,0.006194041,-0.02615796,-0.046721913,0.05993556,-0.0004105701,0.024326298,0.0027186403,0.041395325,-0.03392887,0.010087082,-0.023531627,0.018082235,-0.097781576,-0.004019091,-0.061469126,0.07589206,0.05291198,0.013259928,-0.025975483,-0.0025283513,0.0033921518,0.03481841,0.038483914,0.06337384,-0.005219543,-0.03974712,-0.13302493,0.034040958,-0.040187765,-0.0034449764,-0.023501437,0.08707323,0.0713886,-0.024069835,-0.10283387,-0.008221574,-0.058074173,-0.026617557,-0.07040432,-0.016046172,-0.04765996,-0.053317476,0.029509857,-0.034466807,-0.021220678,0.0074197184,-0.043360803,-0.016653206,0.02197322,-0.08448048,-0.027809024,-0.04901058,0.038518224,0.070832215,0.2483126,0.021945326 +4.1.1.84,"This enzyme is specific for D-dopachrome as substrate and belongs to the MIF (macrophage migration inhibitory factor) family of proteins. L-Dopachrome, L- or D-alpha-methyldopachrome and dopaminochrome do not act as substrates (see also EC 5.3.3.12, L-dopachrome isomerase)",384,1.0,-0.040515885,-0.119493306,-0.0066594607,-0.04745801,0.09541488,-0.015681475,-0.066259876,0.09716881,0.012378421,0.0022002044,0.031326503,-0.04328134,-0.044165973,0.091826335,-0.024134714,0.07935949,-0.03863791,0.027442783,-0.0049743685,-0.033987116,0.039221045,0.036853436,0.052754268,-0.0761493,0.028310582,-0.027074974,-0.07192181,0.015667861,0.058196273,0.029568655,-0.051034115,-0.01856124,0.068804584,-0.038779348,0.039219137,0.04697148,-0.008979024,-0.005709615,-0.0675899,0.04778342,0.07515224,0.0012525341,0.021627953,-0.015138418,-0.052637186,0.012219778,-0.05226625,0.044554487,-0.042147107,0.03984768,-0.059869584,-0.088473424,-0.070171446,0.045028374,-0.040282164,0.066267334,0.027747022,0.049164206,-0.007738027,0.006439499,-0.02668582,0.06832009,-0.018037371,-0.009532856,0.050191823,-0.011194028,-0.07649406,-0.025859224,-0.034477163,-0.050601233,-0.008072436,-0.10387674,-0.053473625,0.08789288,-0.0012049249,0.012365277,-0.014845832,0.02176352,0.06380486,-0.077427566,0.03271796,0.019003643,-0.0113709625,0.025727572,-0.014799495,0.023732396,-0.047685284,0.032389063,0.022219108,-0.0074519855,-0.011245462,-0.030097647,-0.1018331,0.026784966,-0.08606448,0.015719391,-0.029497273,0.081694536,0.004680406,0.02652541,-0.032207776,-0.026745412,-0.062067196,-0.060967032,-0.12807107,-0.07706393,0.012841731,0.041427165,0.009728189,-0.07432285,0.085562944,0.021871941,0.09829964,0.055168483,-0.033822007,0.017721968,0.051288497,-0.071454674,-0.020788709,-0.04947257,0.012248232,-0.027266316,0.068678,0.0386247,-0.034822006,-0.031041266,-0.07645961,1.3536946e-33,0.07844768,-0.054177456,0.034438428,0.017937701,-0.0069287564,0.00965084,-0.048018746,0.02574751,-0.05337782,0.008659384,-0.010025235,-0.035563614,0.017173346,0.050790664,-0.042416222,-0.019750629,0.09941156,0.023778632,0.04657739,-0.046230998,0.071449116,0.07936827,-0.040970404,0.0097161755,0.07537223,0.034947637,-0.05071034,-0.037970282,0.06845775,0.024705475,-0.1276631,-0.09981124,-0.0725071,-0.0026329998,-0.059012167,0.034682292,-0.10502754,-0.05899769,-0.06433466,-0.015236034,0.019998053,-0.016486377,-0.05686923,-0.058527693,0.040169552,-0.024939338,0.01028376,-0.03673815,0.020214114,0.07504729,0.07960239,-0.087591365,0.06628289,-0.028649036,-0.13950337,0.0061704,-0.10739303,-0.03454791,0.055830028,0.056157973,-0.0137834735,-0.029522251,-0.017057655,0.07568853,0.06414998,-0.036246285,-0.045923904,-0.049457323,-0.032323666,0.11114969,-0.0028519323,-0.051137455,0.048573148,0.03960346,0.0082382215,-0.09556054,-0.00028249004,0.03312838,0.012351432,-0.057606522,0.019581398,0.0442875,-0.019874183,0.0073943287,-0.06375227,0.0016185425,0.0070938068,-0.0022332678,-0.02835042,-0.014211765,0.0065453313,-0.10266325,-0.027730115,0.107708044,-0.008836829,-3.2258853e-33,0.035173666,-0.06904231,0.049241755,-0.106932074,-0.014467341,0.050690103,0.06265941,0.06288295,0.07483924,-0.019894574,0.030660493,-0.038634673,-0.039121382,-0.033106737,-0.030828422,0.010632674,-0.017929627,0.010013605,-0.01822834,0.010461951,-0.032207426,-0.011275037,0.062593184,0.036005735,-0.0078393,0.033909768,0.0069424463,0.06468675,-0.014852148,0.07294756,-0.06936493,0.06710616,-0.016609695,-0.063717835,0.012824241,0.07284119,-0.027493883,0.034559738,-0.018812543,-0.032870438,-0.031414792,0.04455853,0.05959297,0.06693997,-0.011651441,0.1062326,-0.050825626,-0.041267272,-0.015157948,-0.025076387,-0.0108681135,-0.010926967,0.023785258,-0.011480425,-0.032519877,0.09638156,0.060915455,0.06784516,-0.096214786,-0.019190308,-0.022021694,-0.04058225,0.010532576,0.040762212,0.07772929,0.10597413,0.007046049,0.04851217,-0.07726504,0.002441819,0.04623774,-0.015687598,-0.021816099,0.05764479,-0.05679602,-0.09018265,0.017802436,-0.007829836,0.03632656,0.04994751,-0.02026079,0.0012647152,-0.04089862,0.006925525,-0.017464733,-0.0575533,0.026630424,0.11994943,0.032578625,0.055985406,-0.033854604,0.0048477664,-0.031092232,0.02327948,0.082795195,-3.9335557e-08,0.03873222,-0.07297493,-0.00051018724,-0.038242903,-0.06444057,0.0027050478,0.02497641,0.049697116,0.005712467,0.05989548,0.024697619,0.03252948,-0.036703583,-0.014801624,0.025040401,0.021092394,-0.064037345,0.0052116876,-0.05213272,0.044835705,-0.029729648,-0.001984368,-0.023769872,0.027723799,0.011091456,-0.08964283,-0.0015765786,0.10722113,-0.006663201,-0.061666347,0.02098799,0.042959563,-0.017107354,0.0086823,-0.040260583,0.011591029,-0.013201291,-0.076194346,-0.053865537,0.039312325,0.045847703,-0.010250316,0.05927506,-0.013664759,0.026492512,0.023806736,-0.029164447,0.048915632,0.104052074,0.05621677,-0.018991455,0.009724963,-0.067009896,-0.0928428,-0.12922578,-0.020605063,-0.0054145507,0.011374062,0.024261963,-0.06508274,0.050303396,-0.0029671637,0.17749754,-0.05085502 +4.1.1.85,"Requires Mg2+. Along with EC 5.1.3.22, L-ribulose-5-phosphate 3-epimerase, this enzyme is involved in a pathway for the utilization of L-ascorbate by Escherichia coli.",384,0.99999994,-0.038650196,-0.08078575,-0.015565845,0.03853457,0.083725505,0.038724378,-0.019361477,0.03648485,-0.0148744155,-0.002721989,0.054619767,0.0014975815,-0.019393325,0.049719974,-0.006021882,-0.025881927,0.034483854,0.009224265,-0.06311248,-0.043308217,0.18611336,0.057973154,0.04303378,-0.018549291,0.037405785,-0.006287022,0.024218448,-0.04511784,-0.002530945,-0.08186655,0.044809777,-0.0512684,0.10331939,-0.09910652,0.05116216,0.09929967,-0.049083624,-0.05940648,0.04373961,0.07306591,-0.0043336386,-0.020224612,0.07173609,0.010356994,0.01675131,-0.09269277,0.012530195,0.033411138,0.034853157,0.0068624113,-0.045299366,-0.0021617783,-0.045240056,-0.0702668,-0.035875637,0.025671268,-0.06674967,-0.029519642,-0.037234165,-0.0086003095,-0.032380763,0.029966304,-0.040226463,-0.021264113,0.00043478952,-0.018882222,0.035402317,-0.073131405,0.008949692,0.055442058,-0.0432283,-0.05490126,-0.032427616,0.08992234,-0.011267049,-0.008352094,0.03532587,-0.10011049,0.037215166,-0.008338902,0.00065864425,-0.05713171,0.033888146,0.029810185,0.01455501,-0.0247125,0.027765809,0.067813076,0.0039086496,0.09127996,0.07530514,-0.027648052,-0.009661461,0.033314086,-0.0059610954,0.03472782,-0.0103188,-0.011351502,0.009534334,-0.03205579,-0.021202257,0.07319814,-0.020885086,0.00788401,-0.010500602,-0.00040808722,-0.012471211,0.03489944,0.012744113,-0.02434225,0.06317596,-0.035629597,-0.058515456,-0.021688662,0.04330036,0.050409775,-0.0043845056,-0.15557082,-0.00071720337,-0.002792899,0.05634756,-0.050541792,0.0043225535,0.06946866,-0.098224536,0.02266185,-0.025867604,8.241379e-34,-0.0030148565,0.03221472,0.015999513,0.021743681,-0.07810845,0.09543651,-0.09574393,-0.006998009,-0.007016552,-0.074627176,-0.06788363,-0.080082685,0.0264561,0.019567851,-0.013152056,-0.04484694,-0.048658155,0.034408424,0.08027504,0.028298791,0.032155804,0.027970253,-0.04543328,0.048140384,-0.03312221,0.06269985,0.06264436,-0.035707626,0.10128336,0.0011927345,0.058549777,-0.06860546,-0.06947513,-0.0008909314,0.042958613,0.006318498,-0.035646725,-0.021716584,0.03224405,0.049381837,-0.01062866,0.09990714,-0.02989486,-0.007543547,0.060292054,-0.062227592,0.010443733,0.050746817,0.024022473,0.077314235,0.085418224,0.02253828,0.0714127,0.030100342,-0.022456605,0.047635205,-0.08453685,0.04280726,0.09202398,0.005312624,0.04999976,0.034251407,0.020977898,0.052017115,0.01946778,0.07113419,-0.018806065,-0.07752616,0.0105922,0.07057861,-0.080789745,-0.08649195,0.0599178,0.03624294,-0.032600228,-0.018870268,-0.09961012,0.037123684,-0.014961316,0.020750696,-0.063534155,-0.03462312,0.003478504,0.026770562,-0.022335669,0.03117394,-0.0040066596,-0.03479139,0.06614834,0.03651827,0.09324944,-0.07161157,-0.012054213,0.05668009,0.023366487,-1.5564822e-33,0.0975989,-0.08157282,0.097143434,0.005021918,-0.07617171,0.021907149,0.03342385,-0.11132339,0.05307988,0.011716313,0.0681791,0.008126385,0.03778361,-0.100546464,0.038085878,-0.020386666,-0.029586589,0.09232667,-0.041518133,0.044692487,0.04820795,0.026014159,0.040908374,0.07097489,0.049325995,0.043535464,-0.025891826,-0.029517526,0.001536303,0.003042405,0.015506643,0.03713262,-0.02260214,-0.08534044,-0.09507931,0.046186596,-0.022268392,0.036726303,-0.051996954,-0.0014358442,-0.007903647,0.12599885,0.03996874,0.052382287,-0.03284629,0.061064564,-0.0033366329,0.03780248,0.05480118,-0.06479233,-0.047294006,-0.07739865,-0.05606733,-0.078861155,-0.011270767,-0.017828649,0.0023532992,0.021380931,0.010595612,-0.012042666,-0.019000309,-0.03196117,0.037786555,-0.08836575,0.07348385,-0.0116655305,-0.001055029,0.047221873,0.048680566,0.04141604,0.040378135,0.042212505,0.06745453,0.008021423,0.03971904,0.015392131,-0.104803376,-0.022926422,0.014638466,-0.054452103,-0.022521496,0.034159318,-0.034922544,-0.023035677,-0.025764812,-0.17813374,0.016840458,0.084660456,-0.017687675,0.041311856,-0.10264576,-0.10014118,-0.008609794,0.05466308,0.050455417,-3.4084607e-08,-0.0042941603,0.012816848,0.029855985,-0.089891054,0.016123036,0.057626132,-0.03215333,-0.010047402,0.114857264,-0.057226893,0.058020294,0.041045632,0.014716731,0.028902449,-0.0066035786,-0.021856925,-0.05331236,0.032074124,-0.0072295927,-0.020900149,-0.035057105,-0.047691032,-0.07817599,0.003456838,0.024429107,-0.016255148,0.022313815,0.09794344,0.03499891,-0.047248285,-0.0071332497,-0.0035074616,0.019913968,-0.04110059,-0.070957094,0.06319791,-0.051701505,0.0036422596,-0.039878935,-0.016391298,-0.03602192,-0.06774171,-0.0023466973,-0.0029032223,-0.052654825,-0.026383258,-0.009770507,0.034585692,-0.078604445,-0.03965894,-0.0089218775,-0.08798759,-0.0651007,-0.02326158,-0.046770535,0.029344194,-0.007389677,-0.09900004,0.018647205,-0.11116461,0.017954875,-0.021960119,0.068853416,-0.049506634 +4.1.2.5,"A pyridoxal-phosphate protein. This enzyme is specific for L-threonine and can not utilize L-allo-threonine. Different from EC 4.1.2.49, L-allo-threonine aldolase, and EC 4.1.2.48, low-specificity L-threonine aldolase.",384,1.0,-0.017320191,-0.097418986,-0.016891714,-0.06429356,0.07068878,0.03695858,-0.07567473,0.053412512,0.02055832,-0.0155890575,0.030366015,0.00071526796,-0.07742367,0.08189902,-0.03308518,0.04643337,-0.055236958,-0.04330305,0.03196128,-0.049250633,0.09061563,0.010998997,-0.0085063735,0.0039644483,0.075458474,0.030825436,-0.015681798,0.05746863,-0.016934117,-0.05647129,-0.083806664,-0.04547154,0.011777482,-0.031957656,0.07199508,0.10618954,-0.15267333,-0.03930437,0.03640383,0.024811992,0.09874578,-0.08213973,-0.035054296,-0.029437365,-0.0456887,0.012920949,0.021717383,0.02566712,0.014470545,0.029613007,-0.041396447,-0.036016364,-0.06425634,-0.010496391,-0.041127667,-0.0038678236,-0.0065482776,0.030852716,-0.0462745,-0.01761431,-0.0009066617,-0.0074222246,-0.020182967,0.011277157,0.07375742,-0.029492904,0.03527534,-0.067436635,0.0010580093,-0.0416366,-0.011210744,-0.049542263,0.08299876,0.100446634,0.059694257,0.021467352,-0.041475654,-0.004523651,-0.040294502,-0.006487214,0.057430565,0.010109064,-0.002741197,0.037608046,0.029109718,0.009587212,-0.024075754,0.012821868,0.027911982,-0.046274252,0.05270824,-0.024789985,-0.03853681,0.0046197968,0.0392911,0.010646442,-0.018470848,-0.0036046852,-0.050827388,-0.0661553,0.022880638,-0.0046454985,-0.03992662,-0.056136653,-0.014157782,0.05690483,-0.005288566,0.027599508,0.0017684537,-0.06795325,-0.014013415,-0.007832582,0.080011435,0.0003557506,-0.007231545,0.015415604,0.008188003,-0.06677302,-0.009831435,0.018625215,-0.00073788496,-0.06644425,0.08893851,0.0960215,-0.0215915,0.05077271,-0.12784474,1.7056485e-33,0.10161944,0.06879524,0.03177261,-0.05930769,-0.0001924907,0.013110023,-0.078172274,0.044340584,-0.069734186,-0.041630384,5.0880877e-05,-0.022901857,0.075741485,0.022507487,-0.054880798,-0.01907649,-0.022694148,0.059488498,0.08394475,-0.046256956,0.002554491,0.055104826,-0.057131667,0.12819995,0.0060497927,0.09179863,0.043486338,0.03658631,-0.044740304,-0.011605868,-0.060091816,-0.066768035,-0.05684587,-0.029792456,0.025115456,-0.05252988,-0.074794345,-0.036845118,-0.0024730044,0.032699615,-0.0289938,0.035452727,0.001975025,-0.049973093,0.016671224,-0.1122372,-0.0561578,0.07313941,-0.054752935,0.049742665,0.0618881,-0.082250334,0.04898767,-0.029547743,-0.0963774,-0.007629257,-0.03653626,0.03414209,0.04355574,0.028870959,0.11617397,0.043496326,-0.03675418,0.009988186,-0.054621823,-0.0085590705,-0.06371949,-0.06703774,-0.008400189,0.13119978,0.012418128,-0.04064931,0.08877995,-0.00790075,0.058758795,-0.07717322,-0.08790656,0.066483416,-0.00504677,0.038055666,-0.022905627,-0.0013471046,0.015539718,0.0073584113,-0.08592904,-0.029081486,0.07623001,-0.047579568,0.04860714,0.02475616,-0.026347807,-0.07585438,-0.037504263,0.051612567,-0.004439067,-2.2137473e-33,0.08258591,-0.066940784,0.110948674,-0.018594941,-0.040242687,0.043304328,0.07690644,-0.03573886,0.061384916,0.021564707,0.15416981,-0.07132936,0.007388895,-0.0885572,0.0789618,0.01343798,-0.10975891,-0.026615849,0.04515251,0.08664747,0.0042275344,0.0017944811,-0.03004739,0.059160255,0.094484985,0.00045728043,-0.015166845,0.04668418,0.052264165,0.0061423276,-0.07871278,0.026225429,-0.014230906,-0.032102033,-0.06779823,0.04267899,-0.07433591,0.040372524,0.036832977,0.022101713,0.042088874,0.029905707,0.07506721,0.041881956,0.017854368,0.006425732,0.008298662,-0.06514013,0.0064681186,-0.05127895,0.024769861,0.028486354,-0.0041488423,0.0115952445,-0.018042242,0.07935593,-0.0060036387,0.03505138,-0.06382734,-0.036200978,-0.035218604,-0.100208275,0.03709546,0.07646237,0.05208254,0.04081891,-0.03908913,0.024983263,0.044463955,0.03925431,0.09918386,-0.04649072,0.049835753,0.0701678,-0.026299668,0.008381891,-0.08655932,0.046240218,-0.008659167,-0.028732657,-0.031483646,0.0008087412,-0.023399444,-0.023686983,0.0045070946,0.0030397596,0.07159656,0.085968606,-0.012152384,0.021503499,0.019312503,-0.022536848,-0.020463627,0.02512073,0.07867419,-4.17059e-08,0.0735407,-0.07017579,-0.0065674894,-0.009665676,0.026569733,-0.053944264,0.017664587,-0.011011717,0.0491466,0.023056624,-0.005942891,-0.002654509,-0.033114757,-0.047243122,0.07870886,0.012979255,-0.07501826,0.044994634,0.0033141095,0.035359774,-0.06010963,-0.013480214,-0.12017167,-0.040886782,0.026622726,0.009529778,-0.01993999,0.00753116,-0.00888057,-0.028265424,0.039362036,-0.016032077,0.004803866,-0.10410662,-0.030938754,0.06293052,-0.05503353,-0.031853706,-0.0578195,0.010993914,-0.0272863,-0.044355,-0.03310976,0.023845453,0.032876834,0.022981698,0.020140043,-0.060277615,-0.00404218,-0.001752665,0.025536554,-0.023107076,-0.023053424,-0.11239763,-0.050443947,0.074709095,0.034059707,-0.030295346,0.02535334,-0.0947906,0.06812573,0.010284893,0.13916913,-0.047411665 +4.1.2.9,A thiamine-diphosphate protein.,384,1.0,-0.08089331,-0.008508355,-0.052845582,-0.008935192,-0.0099549685,-0.008899688,0.08867158,0.06044833,-0.010204869,0.030642731,0.026736205,-0.048694246,0.006689777,0.0569292,-0.01152731,0.015394125,0.011099636,-0.041505013,0.020707866,-0.049765196,0.005178324,0.12267674,-0.065429695,-0.021972936,-0.021461753,0.067434385,0.059812415,-0.013213148,0.0037130846,-0.08659743,-0.12188814,0.012667931,0.03196427,-0.04269946,0.03154372,0.06594522,-0.049162738,0.006926556,0.01582329,-0.033747587,0.126263,0.011330333,0.03322762,-0.018699003,-0.0757644,0.004035201,0.07852067,0.081025325,0.05880025,0.06895604,-0.061526455,-0.025555525,0.030837726,0.01387693,0.03475142,-0.044965696,-0.028472142,0.012775305,-0.03833213,0.026187284,-0.015264927,-0.042473573,-0.008844242,-0.04815847,0.17117983,-0.09913953,-0.008820532,-0.017523,0.04000238,-0.050130356,-0.032900088,0.021681247,0.051384714,0.035435114,-0.053553376,0.046780013,0.022324312,-0.030239535,0.069951884,0.012469383,0.008797224,-0.012904543,0.026385494,0.087267354,0.039287515,-0.030835873,0.01601314,0.045591533,-0.039443683,-0.05858424,0.018343266,0.009375835,-0.033803824,-0.0018618377,-0.104120106,0.03737714,0.00797313,-0.038440265,-0.07663245,0.026142927,0.08903679,0.020288698,0.0021568767,-0.058109432,-0.023168389,-0.018907152,-0.0023633735,0.04043457,-0.0017141431,0.040040616,-0.0026129305,0.040709913,0.045801893,-0.008293402,-0.042716052,0.017800042,0.010991428,-0.005722406,-0.04034189,-0.056963768,-0.04982591,0.026854457,0.036847793,0.034382503,-0.04761617,-0.03355186,-0.095208116,-2.2230784e-33,0.07071541,0.0539216,0.043020967,-0.017484106,-0.0184938,-0.011922019,-0.038998317,0.04833572,0.0014333928,-0.028858704,-0.020961048,-0.08400749,0.084453315,-0.009150999,-0.038594477,-0.09061495,-0.033317626,0.007078118,0.10663654,-0.046077006,-0.086670324,0.102290966,-0.06016048,0.022663027,0.01470431,0.0074642515,0.0061687194,0.03498647,-0.012059062,-0.0070122755,0.07563373,-0.05090983,-0.09404059,-0.07193445,0.0735814,-0.09375284,-0.028330285,-0.031441115,-0.069042675,-0.032223415,0.054083128,-0.0051815226,-0.029613292,-0.0144490795,-0.0033177834,-0.108701035,-0.03704339,0.034042478,-0.049540874,-0.006718976,0.02695159,-0.03760962,0.11432143,-0.05953667,-0.07911482,-0.026610846,0.010236068,-0.001361554,0.04803166,0.053076603,0.011230352,-0.0054337056,-0.13221513,0.062162194,-0.07170701,-0.0073548863,-0.12419155,-0.040874053,0.061654046,0.06484494,0.057801176,-0.020916007,0.07116711,-0.032153543,-0.07804834,-0.03471738,-0.045287777,0.05918875,-0.023804752,0.04823427,0.095876224,-0.038004152,-0.007299276,-0.02754372,-0.10930528,-0.032703955,0.09118197,-0.04138834,0.01619424,-0.03557237,0.05025907,-0.027462415,-0.061526995,-0.03263133,0.021615144,4.262859e-34,0.08965645,-0.08797283,0.04366342,-0.03858394,0.0033453282,-0.057531007,0.08571825,0.0088385735,-0.039410986,-0.051010437,0.10090465,-0.013583042,0.040143583,-0.05494334,-0.0004678554,0.12240701,-0.03752116,0.059963718,0.06787214,-0.014212277,-0.06711342,0.039587617,0.059169386,0.047719896,-0.035512965,0.025131794,0.03382383,0.0031276224,-0.039735194,0.100473315,-0.020388402,0.025186416,-0.062149014,-0.028382156,-0.091326736,-0.032251753,0.013432346,-0.087447256,0.0033955716,-0.00887085,-0.038586818,0.05670098,0.07864567,0.088383384,0.06332793,0.06600844,0.013713473,-0.019107353,-0.07996807,-0.018728126,0.04630545,0.010541479,0.007797401,-0.0075894357,0.025498688,-0.04259823,-0.036016036,0.02011304,0.042991944,-0.007973789,0.004900771,-0.08420613,0.00014969216,-0.000714559,0.036420736,0.08642689,-0.023579342,0.028929364,0.07375894,0.003395215,0.050824087,0.045550715,0.09741437,-0.029638162,-0.031944513,0.062842816,0.0016379859,0.07843737,-0.035189476,-0.0027150498,-0.03261278,-0.027323106,-0.064616755,-0.019386083,-0.003614757,0.009034124,0.040507123,0.053434446,-0.05227944,0.050296094,-0.09876313,-0.017010696,-0.040309936,0.09723824,0.105813116,-1.7993957e-08,0.028785702,-0.09492228,-0.025458025,-0.032958154,-0.018395964,0.084619135,0.013415192,-0.00010479627,0.1102944,0.039328806,0.023878831,0.0416585,-0.017178888,0.05973567,0.06453927,-0.018341351,-0.024615066,0.0040614037,-0.016355202,0.00702142,-0.010834695,0.0111402795,-0.0012487716,0.009495611,0.022178067,0.027372165,0.0017497846,-0.047776826,-0.0210248,-0.06116085,-0.00033317087,0.030861108,-0.012133413,-0.09617541,-0.01069815,0.07840893,0.0542489,-0.030803885,-0.05276984,0.017684039,-0.0050797258,0.02509206,-0.109584905,0.006026348,0.012833139,-0.020215685,0.013186039,0.119689025,-0.05961564,-0.07459989,-0.04184507,0.020418046,-0.012473562,-0.041026995,-0.051568758,-0.00893825,-0.055236664,-0.01527889,-0.045739975,0.02272791,0.042370535,0.02054589,0.07977227,-0.0334902 +4.1.2.10,"A variety of enzymes from different sources and with different properties. Some are flavoproteins, others are not. Active towards a number of aromatic and aliphatic hydroxynitriles (cyanohydrins).",384,1.0,-0.058923658,-0.109651566,-0.06505691,-0.011328543,0.06316262,0.05077004,-0.0025095097,0.014820165,0.028607156,-0.047176465,0.005197599,-0.028728567,-0.07044015,0.03725096,-0.08119451,0.09284177,-0.08220779,0.0049930452,-0.03179556,0.0069422773,-0.012816604,0.0005402144,-0.007170701,0.056378487,0.013396334,0.023728453,0.0020762142,-0.050331727,-0.050869513,-0.012435465,0.027619796,-0.0020116803,0.03149368,0.008646057,-0.00029095978,0.07429752,-0.0620552,-0.021418216,0.008436136,-0.020917106,0.051607896,-0.047305174,-0.021381304,-0.05414391,0.025628183,-0.05013516,-0.0095598,0.021183511,-0.00016060678,0.041073862,-0.0572486,-0.06330412,-0.09887656,0.08170548,0.02479249,-0.014788725,-0.0683011,-0.0021441297,-0.026807653,0.037561987,0.004303555,0.025247581,0.0073470953,0.008098381,0.0068957764,-0.05153782,-0.018175455,0.005427151,0.07279631,-0.038848456,-0.003907177,-0.07012479,-0.07115905,0.08192695,-0.007728882,-0.007969499,0.021181041,0.0073215324,0.016126106,-0.050242182,0.033524677,-0.015540606,0.04783449,0.13778865,0.0825757,-0.026837738,-0.06617071,0.054109488,-0.018409904,0.066695444,0.031654447,0.04641929,-0.0014012655,-0.03033014,0.0024637913,0.014656181,0.05681195,0.00021597845,0.03253464,-0.0006621579,-0.019059744,-0.010524157,0.0027204333,-0.06954289,-0.07082788,0.026987648,0.026046554,-0.025373455,0.054830555,-0.03847346,-0.03989083,-0.061706986,0.045954872,-0.10277516,-0.01780065,0.03891618,-0.030493932,-0.006217012,-0.03513748,0.010331118,-0.03402355,0.03664785,0.0969729,0.06362924,-0.04134733,0.07738912,-0.09726866,2.1288002e-33,0.11360435,-0.06905519,0.024536908,0.04389571,-0.026779382,0.008313442,-0.02280501,0.047787,0.036937438,-0.06698513,-0.029063098,0.01666862,0.047544044,0.016191361,0.05419466,-0.01661995,-0.024865448,-0.04094302,0.0767152,-0.009509192,0.0354243,0.025367633,-0.09132453,0.050957825,-0.027529491,-0.0141358925,-0.033285186,0.023504492,-0.022621734,0.005771677,-0.01169187,-0.112360135,-0.06627604,0.026426492,0.046731472,0.059142064,-0.0605861,-0.064092286,-0.04100216,0.04610489,-0.09499989,-0.076261975,-0.0008100827,-0.059380714,0.061274815,0.056097582,-0.107334144,0.05780063,-0.0020040895,0.0071892687,0.040153865,-0.04990523,0.11325112,0.039298724,-0.07830133,0.08414321,-0.029391928,0.035444103,0.00472006,0.030891556,-0.01898912,0.05448427,-0.054934792,-0.026223749,-0.046626527,0.06649329,-0.026619477,-0.039262757,-0.025764687,0.080829926,-0.017505322,0.015197972,0.07740647,-0.009321459,0.11396759,-0.0007061821,-0.06990762,-0.018414732,-0.0025480231,0.088855796,-0.0455453,-0.052570634,0.0022804078,0.015189735,-0.0658352,0.02685942,-0.017373463,-0.033128373,0.0073976596,0.01184135,-0.03182628,-0.09428522,-0.029969294,0.013585248,0.014531887,-3.8768402e-33,0.06557584,-0.08884333,-0.03363049,0.02126252,-0.013516399,0.05510797,-0.0015459618,-0.07685095,0.007834272,-0.007547335,0.021993214,-0.053813495,-0.011887022,-0.0148108285,0.0033914438,0.043480307,-0.059972987,0.07163712,0.04825269,0.049763557,-0.058805335,-0.0018484747,-0.0023889395,0.055627942,0.09347972,-0.026368339,-0.051275164,0.02643218,0.046646826,0.05384308,-0.1097764,0.019937417,-0.014876536,-0.061643485,-0.013989571,0.09745524,-0.023781769,-0.020401103,0.01627096,0.07199516,0.01915383,0.020358471,0.08084646,0.06548635,0.07570182,0.11247678,-0.116720386,0.059729904,-0.024515713,-0.026941668,0.029792726,0.075413525,-0.0025013196,0.056106765,0.04393719,0.06586844,0.03277583,0.041863874,0.04022094,0.0047402573,-0.0243644,-0.10350176,0.0052481038,0.041027877,-0.047408253,0.08660804,-0.039572574,0.050345283,-0.029813807,-0.05874992,0.08679969,-0.09966891,0.096521094,0.06979287,-0.020998359,-0.039946236,-0.010062441,-0.02315464,-0.042486288,-0.043248042,0.086405456,-0.02775581,0.056779012,-0.060047846,-0.062494885,-0.009472409,0.03890587,0.010800758,-0.021318093,-0.0022818763,-0.006000167,0.05030333,-0.059478164,0.041205965,-0.015921464,-3.5587117e-08,0.059963327,-0.0612177,0.06455314,-0.020999182,0.049349163,0.027455179,0.019936232,0.030452626,-0.011938379,-0.013704059,-0.014622833,0.06145857,-0.06695897,0.013941957,0.07746054,-0.016317017,-0.026481641,-0.013590467,-0.023681195,0.02502489,-0.06543677,0.05063661,-0.13947001,0.055047587,-0.06119604,-0.05020905,-0.009885092,-0.009037824,0.06387771,0.0028344477,0.0254647,0.0633383,0.038194414,-0.06783338,-0.07095637,0.054080635,-0.053027455,-0.09989196,-0.051243447,0.021172596,-0.08295136,-0.0028779826,-0.03762558,-0.04116032,0.03894377,-0.058349356,0.05333474,0.035945136,0.036781665,-0.01132613,0.02199627,-0.03647137,0.011994694,-0.055550087,-0.041867156,0.0185581,0.013276448,-0.07459631,-0.034738682,-0.11461821,-0.024547467,-0.02314319,0.21470056,0.014303511 +4.1.2.11,"Does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 [(R)-mandelonitrile lyase], EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile lyase].",384,1.0,0.0073595797,-0.072913714,0.029551629,-0.054755498,0.024026746,0.032288924,-0.03143259,-0.03708831,-0.0127754705,-0.06659119,0.059047107,-0.089937724,-0.02440032,0.037423808,0.036133315,-0.008630639,-0.06931367,-0.03956768,0.010490866,0.034637053,-0.032711316,-0.014617154,-0.015123483,0.0029988943,-0.00265607,-0.0060496265,-0.007597851,0.0045841946,-0.019810464,-0.108244024,0.06808512,0.018053759,0.038900957,-0.08811922,-0.041565977,0.03974928,-0.050729677,-0.077613756,0.05407153,0.038771912,0.02668176,-0.04733201,0.0138183655,-0.035756703,-0.027764544,-0.05434487,0.01167855,-0.016770514,0.029644702,-0.016229123,-0.025159646,-0.064881854,-0.01693815,0.08470225,-0.0056801676,-0.0030894724,-0.08891511,0.031356454,-0.012006456,0.06448122,0.0049353777,0.048554257,-0.059771854,-0.021095451,-0.09111641,0.009423953,0.018267192,-0.03904597,0.053267233,0.05500436,-0.004339573,-0.08249425,-0.020066332,0.092642926,-0.0374769,0.0646008,0.024027152,-0.07621867,0.01881241,-0.022412917,-0.053486783,0.0077010356,-0.019551186,0.0596434,0.036293678,-0.011920883,-0.08045213,-0.006730552,-0.0038427336,0.06731476,0.11697065,-0.015623686,0.007684178,0.0033068454,0.025049696,-0.0052078273,0.072892725,0.07031359,-0.06626719,-0.024366224,0.0012303826,-0.012422254,-0.11678959,-0.0367611,-0.033767704,0.031405557,0.053111095,-0.03869741,0.033109352,-0.023101255,-0.027371382,-0.110120125,-0.015496836,-0.11080045,-0.14911048,0.06428616,0.030301537,-0.025748102,-0.07385352,-0.036665887,-0.081078045,0.010789155,0.03940212,-0.014190225,-0.009363433,0.02786194,-0.04244202,3.3869324e-33,0.0706437,0.0010933955,0.052469797,-0.009607101,-0.0235999,0.02185331,-0.11149106,-0.0001660856,-0.0016271394,-0.14359148,-0.07195246,-0.03509115,-0.037664846,0.006727347,-0.012259666,-0.01823421,-0.021856878,-0.039369043,0.056140713,0.025382081,0.0066909823,-0.045465887,-0.12751171,-0.025197348,-0.09275257,0.0060825283,0.103428535,-0.0020067762,0.057424363,0.03128081,-0.045311797,-0.026345795,0.0017305535,0.043746997,-0.020678667,0.0484448,-0.054332856,-0.010727584,-0.0023377836,-0.014752947,-0.010044435,0.09497829,0.008357036,-0.031515826,0.04929851,0.0075519667,-0.01936868,0.07973729,0.08488441,0.0582021,0.022805717,-0.016619248,0.012192254,0.043257236,-0.029839016,0.0861616,-0.027962325,0.08973958,0.038165048,0.05597853,0.04136503,0.09000523,0.057785463,-0.055673063,0.067436226,0.11528838,-0.045749694,-0.05247499,-0.04101598,0.008718488,-0.025235705,-0.049511902,0.10557905,0.051691968,0.14182478,-0.033659562,-0.059534837,0.057427768,0.05104985,0.038747028,0.0032492536,-0.021445563,0.082413495,0.033509742,-0.057691347,0.0030605497,0.04261187,0.0424483,0.07438984,0.018014688,0.042503297,-0.09414067,0.050781306,0.016288457,-0.043220308,-3.7573237e-33,0.028717529,-0.050455656,0.0020919691,-0.006034323,-0.002461705,0.043797746,0.03518029,-0.0020054616,0.06438974,0.038094547,0.16359177,0.027862016,-0.030758299,-0.08760732,0.027451577,-0.0658017,-0.024418607,-0.00047824142,0.020972865,0.022598576,0.016149856,-0.03778424,-0.02315315,0.030081732,0.07855678,-0.041190248,0.061029095,0.005205157,0.082753494,0.0031367065,0.008703038,0.023792658,-0.12864684,-0.013152585,0.033344742,-0.017757824,-0.03289594,0.07289305,-0.040280223,0.05501268,0.030184597,-0.027941592,0.048983853,0.09524358,0.04259771,0.011571354,-0.04025463,0.010164629,0.019491801,-0.060914543,-0.02819799,-0.0021962621,-0.013891341,0.010531146,0.019070517,0.062477544,0.040890243,0.032492816,-0.0028150151,-0.081307754,-0.08574621,0.012996796,0.021209141,-0.041142423,-0.019133508,0.02205129,-0.071778655,-0.0053374753,0.05195485,-0.072528586,0.016683903,-0.0950116,0.08509763,-0.014683734,0.019470872,0.0035155772,-0.0115488395,-0.07317608,-0.011700053,-0.040779345,0.10563461,0.04129175,-0.022807674,-0.012684954,0.05755106,-0.013101526,0.008742404,0.029530859,-0.0632007,0.06825359,0.02490639,0.026573222,7.753139e-05,0.0836737,0.07846337,-4.35028e-08,0.044991508,-0.04940476,-0.00734214,0.016997956,-0.004161677,0.02455869,-0.016371163,-0.04023748,0.019648774,0.0008673704,-0.029316217,0.029103959,-0.04800901,0.03214101,0.023764819,-0.044012967,0.0029311976,0.07025308,-0.019160505,0.0516691,-0.093402915,-0.03158014,-0.065495215,-0.014542943,-0.034228597,0.020628605,0.07917831,-0.043607395,0.0040211915,-0.033439867,0.04076519,0.059854597,-0.030991394,0.011246789,-0.024332885,-0.029775936,-0.07749795,0.03266852,-0.027594535,0.03041777,-0.013514077,-0.04673544,-0.03294367,0.026842669,0.04780385,-0.031308483,0.0032070577,0.104548074,0.0066319574,0.05256009,0.09460113,-0.0830469,0.045430962,-0.12887816,-0.024122585,0.042744447,-0.026691189,-0.079785004,-0.011858889,-0.10045837,0.00032714097,-0.05082027,0.13359103,0.05158275 +4.1.2.13,"Also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.",384,1.0,-0.06778811,-0.0924281,-0.041872345,-0.037717286,0.048940998,0.023141105,0.020032136,0.0034882324,0.012488198,0.03714999,0.0010981885,-0.010623844,-0.035275538,0.08708577,-0.033554982,0.007846194,-0.026545068,0.033623677,-0.010525858,-0.004458883,0.07739657,0.032243125,0.009631748,-0.03929666,0.008179031,-0.02483309,0.0504466,0.0015676207,-0.019526945,-0.08548519,-0.065632045,-0.021600336,0.054370925,-0.017530028,0.030945363,0.0778644,0.03348481,-0.03893134,0.043982822,0.021733189,0.022551564,0.009679183,0.027591303,-0.052842997,-0.020452738,0.050789427,0.10459577,-0.0014421459,0.052001502,-0.023326667,-0.09884815,-0.062238567,0.018265441,0.0122254295,-0.022207687,0.007578017,-0.04747285,0.04404165,0.0018677096,-0.020727124,-0.00028542697,-0.0504795,0.100139424,0.047928445,0.032448668,-0.0876229,0.02863456,0.016795328,-0.042141538,-0.07748089,-0.03424406,-0.0723654,-0.064315625,0.010578898,-0.00071801356,0.05361687,0.054929376,-0.09285243,0.0108380215,-0.017093718,-0.047905125,-0.009035913,0.07489125,0.037573416,0.036049623,-0.061153114,-0.013087675,0.05165658,-0.02251164,0.084918514,0.017643135,0.0012431655,0.016311986,0.001925565,-0.05597175,0.027073696,-0.019487593,0.0096738925,0.052954365,0.0032520844,0.022212597,0.0896288,0.027964206,-0.01613366,0.004342742,0.04510367,0.042302575,0.08745558,-0.020860951,0.060970236,-0.0014695055,-0.031342227,-0.01642836,-0.027474286,-0.020156432,0.023117304,0.099684626,-0.0017998846,-0.06550449,-0.03573982,-0.00076329376,-0.015366305,-0.006726407,0.031951353,-0.061117284,0.08190965,-0.10065793,-3.9326652e-33,6.9561975e-06,0.015349117,-0.010957973,-0.05170553,0.002755067,-0.04754408,-0.0068542836,0.01703685,-0.056278076,-0.033819716,-0.035462417,-0.02106094,0.120837584,0.008618918,-0.06789064,-0.02088786,-0.049248673,-0.02089341,0.04473959,0.08189737,0.008914647,0.012138363,-0.03041447,-0.0026896708,0.08806313,0.014389306,0.011075906,0.029038277,-0.06417244,-0.06405121,0.063708246,-0.09000504,-0.08550167,-0.011461533,0.13529712,0.022022888,0.0061734114,0.047866736,0.007252138,-0.050530292,-0.034156833,-0.027740855,-0.06682257,-0.01687643,0.053897403,0.027921678,-0.07877349,0.049548402,0.026621459,0.015039881,0.0426241,-0.015143491,0.06818226,-0.028726945,-0.049169842,0.059223257,-0.0090776365,0.08500825,-0.010982633,0.031366915,-0.05808477,0.07050673,-0.020493114,0.0734327,0.004024903,-0.008341931,-0.06334757,-0.06689271,0.03476903,0.110613815,-0.099564604,-0.004160578,0.039453313,0.011920314,0.011619004,-0.015823115,-0.14155416,-0.06637027,0.04943271,0.02909541,0.005265303,-0.14397131,0.039293103,-0.052484646,-0.16817196,-0.030466005,0.0049290066,-0.06729756,0.020928394,-0.025744451,0.074169375,-0.064338975,-0.0029244218,0.06466237,-0.010147227,-1.3606714e-35,0.10728785,-0.0044685234,0.05005838,-0.05607924,-0.093291484,0.05928897,0.021030111,-0.05786153,-0.04640342,-0.015907522,0.08285545,0.023038803,0.011527016,-0.0102828415,0.018299414,0.01903576,-0.0583585,0.10749896,0.037030008,-0.011941372,0.021755619,0.10424436,0.018644841,0.05753069,0.057921328,0.03328513,-0.028131247,0.04493471,0.08419238,0.027731417,-0.04846547,0.045659684,0.020200115,-0.10135008,-0.033828214,0.015414866,-0.055859916,-0.034700118,0.020274015,0.021013279,0.058005363,0.039103005,-0.006872416,0.07783997,-0.01927188,0.094296984,-0.04635605,0.08210569,-0.044427015,-0.035423033,-0.02857858,0.043357085,0.023056338,-0.0017409453,0.0979797,0.023625225,0.046530366,-0.011588376,-0.016941614,-0.00051961234,-0.06455434,-0.087188475,0.049205184,-0.04076945,0.0015998803,-0.033640597,-0.031241443,-0.032960527,0.072573826,-0.023107925,0.059569895,0.08149526,0.04139063,-0.028729917,-0.06955396,-0.05864758,-0.034028977,-0.060496427,-0.034153897,-0.035834093,0.023097599,0.044152483,-0.010208648,-0.0067028776,0.00689824,-0.02150656,0.037941277,0.047854982,-0.032660328,-0.010439007,-0.076394185,-0.0008600894,-0.02685024,0.018841445,-0.09859436,-4.0038188e-08,0.05272852,0.0029033644,0.09087206,-0.038744498,0.007922239,0.009835808,0.012759805,0.022721741,0.053366628,0.03854476,-0.01634,0.12339452,0.067653574,0.018169627,0.10993071,0.010196259,-0.10625611,-0.056549896,-0.018160172,0.018875899,-0.015430482,-0.047105215,-0.1404917,0.08286821,0.024604127,-0.07981089,0.031361558,0.050696895,-0.018527616,-0.026556792,-0.05440917,0.025139127,0.036853,-0.012227344,-0.05009322,0.0034713908,-0.08428954,-0.10294855,-0.049484424,-0.008897439,-0.023082236,-0.04073347,-0.069856286,-0.016821649,-0.06602971,-0.017413631,-0.023109125,0.042629354,0.014007983,-0.029573647,0.018684734,-0.019533519,-0.06270785,-0.03688364,-0.045877807,0.0719157,-0.03106861,-0.048549287,0.033075377,-0.00039418755,0.03487602,-0.049605828,0.11648767,-0.10538757 +4.1.2.14,"The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D-galactonate. cf. EC 4.1.2.55, 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase [2]. Also acts on 2-oxobutanoate [1].",384,0.99999994,-0.014231633,-0.108165845,-0.036924887,-0.043370817,-0.017187433,-0.03601291,-0.06863401,-0.0035619915,-0.011769294,0.04178103,-0.0105728945,-0.024656951,-0.101889014,0.06933478,-0.046971463,0.070762925,-0.04756211,-0.008856166,0.07045067,0.045534942,0.12624384,0.018683532,0.002084913,0.04663527,0.13519058,0.031459793,0.06323433,0.015680237,-0.047183625,-0.049318735,-0.01492956,-0.06822475,0.040894736,0.0033028116,0.04756598,0.14289033,-0.04372844,-0.051825754,-0.03818337,0.022129564,0.010867823,-0.061305374,0.01805772,-0.01984764,-0.010942324,-0.056076705,-0.06598285,0.026927097,0.0411057,0.018522302,-0.05342712,-0.120926425,-0.03658225,0.003956711,0.004527466,0.056410592,-0.007128311,0.035409924,-0.050450083,0.037547898,0.049909603,0.037279803,0.00039978424,0.03172687,0.04121191,-0.0042473185,0.022089863,-0.07726215,-0.026313879,-0.069819346,0.028035207,-0.10948637,0.0114947865,-0.02926854,-0.014860247,-0.016721116,-0.037474383,-0.020633755,-0.0043632053,-0.09347857,0.03894035,-0.00619369,0.023028446,0.04274359,-0.008145319,-0.02571028,-0.05580525,-0.0048084194,0.03704121,-0.030198153,0.010188462,-0.006959657,-0.07850186,0.010095761,0.006681316,0.016710734,0.0038413755,0.033198163,-0.012227576,-0.0040822625,0.01813799,0.08435298,-0.074495986,-0.044101026,0.041111458,0.11436357,-0.0046433546,0.061633367,-0.038966514,0.009612808,0.012401737,-0.0074858954,0.06491399,0.014482553,-0.009989619,0.10596966,0.0345957,-0.05861407,-0.07399738,-0.005201881,0.02523881,-0.057319835,0.09453985,0.0035794775,-0.044042036,0.06442442,-0.024967015,8.9331e-34,0.12539215,0.0047850213,0.024117688,0.035123643,0.027318893,0.046437856,-0.04668269,0.014022876,-0.041615993,-0.02701515,-0.0678319,0.019805437,0.095910504,0.013298257,0.012991418,0.0560042,0.056035332,-0.02149481,0.096174166,0.019423654,0.06779506,0.019912716,-0.08745336,0.056050424,-0.011000356,0.08541586,0.010307778,-0.0018938377,0.035019714,0.0144167505,-0.01542062,-0.087265745,-0.09493659,-0.056995817,0.01960611,-0.01388775,-0.11227751,-0.0022163026,-0.025858128,0.0035087261,0.023507675,-0.036770087,-0.026414568,-0.07251206,0.040011074,-0.03927515,0.018365731,0.10183292,0.039173387,0.09762551,0.08283943,-0.043735873,0.034148484,0.0374372,-0.05355515,0.04894515,-0.04087833,0.02585861,0.094680056,0.035539284,0.07900946,0.060679585,0.0075573646,0.023350298,-0.014269595,-0.0035455523,-0.050916478,-0.006060872,-0.07369862,0.053451903,-0.053111527,-0.049376108,0.046225473,0.01915949,0.011974314,-0.07493301,-5.3318676e-05,-0.0031478927,0.001145607,-0.014193374,0.082398824,-0.028354472,0.07337275,0.010649769,-0.016813999,0.057641596,-0.030618157,-0.043594882,-0.09270389,0.07761145,-0.012153999,-0.00065380905,-0.10062389,0.021832602,0.03579357,-2.5396342e-33,0.09310274,-0.10242966,0.07306427,-0.07511087,-0.043343436,0.0729643,0.030687664,-0.004583873,0.07152224,0.00457302,0.13677596,0.008554286,-0.0384619,-0.103995726,0.024591526,0.027952699,-0.058816686,0.03993343,-0.026446223,0.0162209,0.042691167,0.12703606,-0.054436762,0.04742368,0.05706799,-0.0382398,-0.0042472933,0.025633713,0.04395697,0.05406537,0.012367216,0.033777457,-0.018449705,-0.080583595,-0.03937585,0.07845718,-0.1051175,-0.024589371,-0.020039668,0.031956255,-0.035849053,0.05301121,0.053783905,0.05204233,0.06741419,0.062192872,-0.06507523,-0.032855675,-0.0052589793,-0.029880008,0.041860785,-0.040601756,-0.062866636,0.06304729,0.070765495,0.058175962,0.010831037,0.036409624,-0.03879765,-0.029843925,-0.010932337,-0.028272845,0.02142505,-0.07087964,0.06430549,0.040195584,-0.029142594,0.08456288,0.04277277,0.03009447,0.059567265,-0.013273864,-0.026887368,0.008877714,-0.03501565,0.03573786,-0.11726295,-0.0036012763,-0.017677048,-0.07445405,0.042887174,0.018101828,0.04996284,-0.017432615,0.0032284134,-0.060826004,0.06956159,0.07962237,-0.099926345,0.035091244,-0.013903772,-0.012303858,-0.06657601,-0.021203602,0.050747506,-4.34591e-08,0.028740853,0.02476229,0.049537815,-0.095319405,0.012354456,-0.01995914,0.03391114,0.019647015,0.017885715,-0.023386456,-0.040159363,0.048842162,-0.023823394,0.006762874,0.011701881,-0.021947281,-0.008615963,0.020674461,-0.073103376,-0.019324947,-0.017705396,-0.0063416716,-0.10901525,-0.019339195,-0.0066747605,-0.03196075,0.03307749,0.033607777,-0.0010475498,-0.040762838,0.01473261,0.007818384,0.015244523,-0.057228096,-0.053560507,0.020209357,-0.050276108,-0.007192321,-0.06042155,-0.036202826,-0.055939797,-0.11574019,0.030933306,0.026091732,-0.040224083,0.04544947,-0.013926933,-0.004182329,-0.020481003,0.0034018334,0.04946124,-0.007061949,-0.07167059,-0.061315194,-0.07337598,0.019018704,0.026702577,-0.071621,-0.013101196,-0.122918926,0.0706798,-0.074412055,0.0800002,-0.0286145 +4.1.2.21,"The enzyme catalyses the last reaction in a D-galactose degradation pathway. cf. EC 4.1.2.55, 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase.",384,0.99999994,-0.0018173843,-0.026618227,-0.00697518,-0.0071897195,0.010821141,-0.023089431,-0.035261944,-0.011319575,0.053499505,0.06436999,-0.04418493,0.040080387,-0.09342662,0.025131753,-0.07518499,0.047507223,-0.081702374,0.014464196,0.0022241452,0.027514456,0.1733766,0.0055422094,-0.0057895994,0.041060235,0.12849301,-0.019239211,0.041687816,-0.061295938,-0.07074519,-0.068537205,-0.0038020182,-0.06893523,0.06533881,-0.031267595,0.02905449,0.1122433,-0.010955631,-0.08384815,0.015786123,-0.006405267,-0.03357119,0.0014261758,0.00599035,-0.008670411,-0.026730644,-0.0029023387,-0.09155078,0.04870848,0.050259676,-0.009787001,-0.017494613,-0.08128667,-0.067742676,-0.01970265,0.07473889,0.068460114,0.004006711,-0.012204843,-0.014190621,0.05535992,0.08143369,0.06036787,-0.07744658,0.022993116,0.023895066,-0.059139304,0.07555995,-0.061352234,0.017313885,-0.03966242,-0.03626492,-0.10735255,-0.049302053,-0.06206179,0.041660123,0.014541147,3.528918e-05,-0.056885913,-0.0111956885,-0.053409763,0.080861844,0.008065621,0.051636193,-0.009789762,0.0012436562,-0.029698374,-0.008583934,-0.02326545,0.04679827,-0.032198597,-0.016284557,-0.05598089,-0.0056182803,0.025185848,0.01023612,0.039000202,0.030426148,0.030543445,0.078677274,-0.028112967,0.0023719722,0.04353927,-0.013933053,-0.062199604,0.034326535,0.093201466,0.0041373908,0.15120101,0.019609991,0.024960218,0.016116016,-0.017642228,0.0534018,0.07120214,-0.023751358,0.110731594,0.0062973993,-0.03504888,-0.038893554,-0.021493526,0.025056431,0.0014314258,0.044481166,0.030323453,-0.03448466,0.09331067,-0.007722901,5.132636e-34,0.105336525,0.015154228,0.017664213,-0.005756272,0.016858099,-0.009147946,-0.05181864,-0.003046199,-0.059044678,-0.0059348163,-0.08070189,-0.04303155,0.0047159065,0.022340117,-0.028098581,0.010119737,0.054057587,-0.0032697527,0.059320558,0.02571568,-0.044241715,0.0470528,-0.06861018,-0.0034858368,0.06548762,0.094289735,0.017463729,0.06466852,-0.015029318,-0.012767739,0.0011164119,-0.06669769,-0.09239355,-0.021810409,0.0048187817,0.012679944,-0.057515375,0.016708076,0.012704341,0.013604818,0.019625682,-0.0026428697,-0.040083777,-0.04423642,0.033769652,-0.013664275,0.004572691,0.10367918,0.022424875,0.07139634,0.04382502,-0.039624654,0.04279793,0.060172107,-0.07203725,0.037989113,-0.013434509,-0.022709334,0.059582375,0.031666342,0.050277714,0.059331875,-0.011270134,0.05192578,0.041884445,-0.011790101,-0.039586924,0.010576006,-0.0761425,0.056975346,-0.12254821,-0.05790886,0.04449073,-0.046068616,0.030894635,-0.06906704,-0.03214128,0.010328478,0.013172989,-0.008174295,0.04857526,0.04790098,-0.017658964,0.010333393,-0.011416041,0.061019853,-0.027097564,-0.083972216,-0.038919218,0.111442745,-0.08611997,-0.037146345,-0.037288833,0.07748569,0.020275256,-2.2204249e-33,0.1163538,-0.07605721,0.059822757,-0.059838463,-0.06269416,0.050502297,0.019052405,-0.0075493176,0.026995216,-0.024120612,0.061240237,-0.0065577077,0.0041205785,-0.06794906,0.019278824,0.008485603,-0.0091612255,-0.0040385267,-0.08689551,-0.0015753583,0.033831067,0.1148028,-0.0684455,-0.010614203,0.05687389,-0.07151457,0.015395891,0.039865743,0.047074713,0.005992712,0.028441783,-0.045182806,0.008376124,-0.03300161,-0.05181119,0.08081008,-0.09736211,0.010011476,0.0052215145,0.06146827,-0.0034207404,0.05042001,0.051999755,0.014043632,0.11281119,0.05405791,-0.075792186,-0.0009624423,0.026160944,-0.008511939,0.032681484,-0.052182138,-0.038776103,0.06384224,0.016294088,0.062363032,0.05789537,0.035091404,-0.017384846,-0.044247083,-0.049775824,-0.020112697,0.12962162,-0.043083586,0.056986757,-0.0056331586,-0.06676647,0.07780515,-0.005415585,0.015348842,0.07396116,0.006641484,-0.050857104,0.034053877,-0.020759065,-0.03625021,-0.17570703,-0.016023988,-0.018489582,-0.033347625,0.06743412,0.032428797,0.041796513,-0.017746737,-0.020408932,-0.098090224,0.061526615,0.101483345,-0.03765694,0.03497372,-0.016191743,-0.0693283,-0.043086067,-0.025852904,0.051125303,-3.44688e-08,0.034588154,0.051220037,0.0018861783,-0.054531462,-0.0019389064,0.0019339034,0.04868323,0.05724678,0.04099155,-0.05031266,-0.049200427,0.10102834,-0.010651755,0.004325001,-0.03682269,-0.010744197,-0.04785953,-0.044339933,-0.008010418,0.010551262,-0.049717445,-0.057964023,-0.10438468,-0.0037468898,0.0021450126,-0.06501259,0.07368786,0.056691583,-0.027627453,-0.014883776,0.028144361,0.044144884,-0.001317652,-0.032717463,-0.049196303,-0.018454595,-0.044473894,-0.016659847,0.024948005,0.009843002,-0.060714014,-0.074914075,0.007422857,-0.0028344397,-0.067432486,0.01618193,0.011993611,0.016578808,-0.051870946,0.07959693,0.039363537,-0.054504946,-0.10219443,-0.052211147,-0.052438803,-0.04483834,0.021755282,-0.01788378,-0.0017017506,-0.10037769,0.070339724,-0.053651188,0.12222555,-0.057233404 +4.1.2.22,Also acts on D-xylulose 5-phosphate.,384,1.0,-0.09286957,-0.12191935,0.016431656,-0.0155602675,0.053428903,-0.029761955,0.055372402,0.025765046,0.053591203,0.06472206,0.072870485,0.06864622,-0.06212892,0.09852654,-0.008483307,0.018506946,-0.057880517,0.060229097,-0.080324925,-0.0021662791,0.13179165,0.03679702,0.007929521,-0.060282916,0.07802891,0.02315187,0.047073063,-0.0132421795,-0.017363036,-0.07636959,-0.025142783,0.007872671,-0.0056547318,-0.074774235,0.052081805,0.116674684,-0.013413129,-0.011029475,0.02622547,-0.045727648,0.084866636,-0.123649925,0.038171165,-0.020333841,-0.06324221,0.0045339824,-0.017709224,0.05552131,0.03694562,0.028990995,-0.036697254,-0.062169544,-0.022297043,-0.038145084,0.032942466,0.021203881,-0.038418695,0.050014693,-0.030172173,-0.037658986,-0.012124249,0.055937085,0.0022943337,0.07151584,0.029659647,-0.06523196,0.046023697,-0.06427113,-0.02834613,-0.021077339,-0.022867665,-0.042814713,0.010479439,-0.009881688,-0.021155525,-0.017684791,-0.032579727,-0.11445754,0.04686386,-0.0154345995,0.034273703,0.085814334,0.0691177,0.063342825,0.026848145,0.0072471844,-0.015066056,-0.025298113,-0.06442243,-0.015391652,0.014124512,-0.0026447242,-0.05003723,0.012439662,-0.050919443,-0.004514933,0.08526239,-0.008306824,-0.026287407,-0.028328927,-0.029318957,0.03559599,-0.029410359,-0.064091966,-0.03917948,-0.044429034,-0.035541456,0.050567776,-0.07372468,-0.047827154,-0.036034618,-0.04465406,0.013717061,0.01926166,-0.0698464,0.05474319,0.04139558,-0.011553652,-0.09356478,-0.07559515,-0.030538304,-0.071647875,0.008525407,0.085207224,-0.09072071,0.03193639,-0.020829001,-1.8549808e-33,0.037724562,0.019913454,-0.026948035,0.004084897,-0.022578556,-0.0036899215,-0.02463403,0.034091793,-0.05173274,0.025686964,0.020226013,-0.077511325,0.09185398,-0.01787921,-0.07185453,-0.0031241137,-0.05445259,0.023109747,0.045309637,0.015338838,0.087925516,0.10091358,-0.049133312,0.03516444,-0.016000563,0.038741518,-0.021264583,-0.0038279742,0.0596335,-0.013633971,0.013310274,-0.03672399,-0.042742368,0.038478263,0.029328866,0.08631508,-0.07422814,-0.026281321,0.0053262287,0.018542703,0.015932243,-0.05306293,-0.042131383,-0.050301507,0.020203816,-0.018345231,-0.084371455,-0.01087318,-0.0011950243,0.036611415,0.098592065,-0.0015456561,0.052631374,0.0011780869,-0.04004016,0.009982298,-0.027060939,-0.03796087,-0.02739897,0.062104527,-0.0101915635,-0.014258323,-0.053382233,-0.019614624,0.03755595,0.00082481245,-0.04417449,-0.09468619,0.0052103256,0.06533029,-0.054843176,-0.02629873,0.13972598,0.012556001,0.015835697,0.029919712,-0.053417467,0.035051346,0.044259768,0.05292032,0.058899682,-0.060192697,0.06410926,-0.046590373,-0.031074436,-0.0036028957,-0.014919554,-0.08234156,-0.007671832,0.00471948,0.08817407,-0.14698306,-0.07585315,-0.0044978587,-0.001692076,-4.9457143e-34,0.042744268,-0.035327338,0.030773137,0.03452158,-0.046912707,0.022426281,0.019540492,-0.019491212,0.028270068,-0.0033470234,0.079229325,0.020560132,-0.058029924,0.024543172,-0.006473679,0.07978096,0.028202346,0.06456043,-0.025513504,0.015602101,-0.004207653,0.09102266,0.06729112,0.103229485,0.11492494,0.031180337,-0.009767704,-0.038768824,0.025542537,0.043270748,-0.0064197173,-0.0027868727,-0.06373752,-0.056511786,-0.040889487,-0.007965687,-0.073954314,0.01636877,-0.05226183,0.022284748,0.018136384,0.008106692,0.13850343,0.07927707,-0.005670393,0.0641521,-0.0034450023,0.020767203,-0.022145038,0.012956388,0.0031893635,0.03389023,-0.05902485,0.01851564,0.012349629,0.12629138,0.077764094,0.054159325,-0.05368435,-0.003214372,-0.059840262,-0.022542942,0.04661716,-0.06862715,0.06041106,0.038326725,-0.014831657,0.059101455,0.058549047,-0.056638062,0.1022551,0.010773879,0.02249218,0.006753845,-0.08767352,-0.08114482,-0.048916824,-0.02773531,0.0012289752,0.025954872,-0.017843045,0.029270705,-0.022077788,-0.054936484,0.01126549,-0.055701517,0.0018040427,0.092210315,-0.016919447,-0.0032238674,-0.028089605,-0.0024416693,-0.010800125,0.034865797,0.12673716,-1.812805e-08,0.0031066043,-0.016776111,0.03505453,-0.084571786,-0.0058739264,-0.03220844,0.06953946,0.07625656,0.09130603,-0.018158827,0.0036743546,0.089001484,0.027404835,0.012139291,0.060287517,-0.01020537,-0.02625527,-0.023271862,-0.06744002,-0.09492563,-0.057375647,-0.04201217,-0.04797507,0.03172632,-0.045277342,-0.081158936,0.060612254,0.03272164,0.018883765,-0.03958352,-0.020596376,0.0050947154,-0.060569964,-0.04430246,-0.03729039,0.094060585,-0.005330783,-0.08010334,-0.03711579,0.04246329,-0.057232827,-0.08818927,8.386682e-05,0.074067466,0.00045212603,0.034662712,-0.025339976,0.013246512,0.0036422668,-0.016897988,0.00375614,0.0013882072,-0.048439443,-0.09440975,-0.09991966,0.0738222,0.013766558,0.013882146,0.06890686,-0.014584354,-0.024066906,-0.009357729,0.15497614,-0.044556458 +4.1.2.24,"Acts on various N,N-dialkylarylamides.",384,1.0,-0.054213934,-0.1009819,-0.04180051,-0.04266587,-0.11176991,0.0091755325,0.05542283,0.013806222,0.049753107,-0.019256199,-0.006597127,0.078974605,-0.09017549,0.024338387,-0.05564252,0.033109345,-0.015954683,-0.047263056,0.008020036,0.07567227,0.037326075,0.027355822,0.04841798,-0.0660084,-0.04160856,0.010873331,0.00047009892,-0.018167268,0.1134317,-0.05920678,0.0530918,0.0042332592,0.008111257,0.01631302,0.023529174,0.028731465,-0.03336613,0.027084503,0.0025133,0.05804419,0.052624922,-0.012821991,-0.016842164,-0.012976358,-0.01599036,-0.019667452,-0.049135163,0.005874648,0.0058203824,0.043604814,0.0019044561,-0.079521164,-0.019658148,0.16657731,-0.046298865,0.01397864,-0.09738015,-0.015105945,0.0070295753,0.031111624,0.0005609735,0.047579743,-0.05258016,0.02897802,0.04281488,0.111553036,0.014091145,-0.02199032,0.03694364,-0.0035025578,0.052807674,-0.03975055,-0.014906141,-0.00074934924,-0.07990826,-0.033035666,0.013976909,-0.0678602,-0.049340893,-0.022088459,0.0062961117,0.052353732,0.027315995,0.07448807,0.04960759,0.024094483,-0.03583491,0.005920932,-0.0018448018,0.027685378,-0.03881006,-0.061147626,0.045606673,-0.028943418,-0.060449697,-0.01823348,-0.030564934,-0.023330636,0.010203393,0.08468413,-0.019427765,0.017783679,0.008952904,-0.05995745,-0.10110166,0.054159578,0.017032024,-0.07611972,-0.05561428,0.0015005553,-0.06503784,-0.020320637,0.069343545,-0.013904384,0.014966073,-0.081161946,-0.014045786,0.03416736,0.024989627,-0.018860353,0.021614501,-0.07141106,-0.04361268,0.03471529,-0.01860193,0.09901998,-0.1454139,-1.8087715e-33,0.09590531,-0.05555547,0.028084358,0.0074301558,-2.5573166e-07,0.049956106,-0.03809655,-0.15991709,0.09438942,0.0035500845,0.03889707,-0.03302027,0.021803893,0.021726657,-0.004995614,0.01645031,-0.0030550885,0.04604888,0.009404785,-0.033145383,-0.0027078195,0.1635231,-0.04386432,0.018775411,-0.024727605,-0.05189418,-0.005884217,0.008653492,-0.0050292383,0.011590541,0.053996813,0.012020636,-0.08516521,0.048984945,0.03391717,0.08441736,-0.004876916,-0.044365726,-0.014259928,-0.057762034,-0.063848376,0.032753345,-0.08753074,0.025315555,0.025045503,-0.02832167,-0.068184555,0.064918585,0.01596301,-0.003979551,0.031693507,-0.01833813,0.06382345,-0.037653677,0.003621613,0.023799747,-0.017612388,-0.064266674,0.0330941,0.00397725,0.04596149,-0.02073805,-0.026974339,-0.04408783,-0.012243426,-0.015207254,-0.09748857,-0.047817167,0.02605691,-0.047748245,-0.09879696,-0.026618736,0.008610947,0.026104929,0.023045884,-0.059990704,0.002855529,-0.032134842,0.015558976,0.07116692,-0.010192696,-0.044305187,0.010585824,-0.04310638,0.044911608,0.02754531,0.0067346166,-0.14800033,0.025941819,0.02531006,0.06575182,-0.06270553,-0.062071286,0.021309253,-0.087573096,2.79258e-34,-0.051866345,-0.0625012,-0.04297383,0.118549146,0.011680019,0.055948928,-0.053613674,0.066160224,0.002480289,0.012738594,0.045866642,0.045036387,0.028453661,-0.07803169,0.13813953,-0.006756538,0.10539262,0.11199883,0.043732516,-0.07465071,-0.022953436,0.019314177,-0.039362542,0.059695847,-0.014670752,0.054473296,-0.013546953,-0.008062037,0.06705913,0.018549625,-0.019403141,0.05245324,-0.06975629,-0.052525602,0.039467305,0.072229005,0.07775285,0.01475395,-0.027796775,-0.067150995,0.03504882,0.0083480375,0.18724665,0.1064097,-0.04231227,0.005041262,-0.05096838,0.011108336,-0.12799604,-0.002748367,-0.030848008,0.022160495,0.013753751,0.034006756,0.05112883,0.022795185,0.019260237,-0.04061257,0.017887102,0.0118021695,0.043440644,0.009809417,-0.06967777,-0.029970208,0.06925405,-0.021601569,-0.06725148,0.015014731,0.025077598,-0.0007392432,0.043541152,-0.010651226,0.02979872,-0.04547853,-0.008887968,-0.07952688,-0.045486163,-0.09809275,-0.0031749536,-0.050731283,-0.044663753,0.015875643,-0.00063368294,-0.0011981947,-0.060604915,0.022690106,0.102967486,0.047771864,0.0141634075,0.022089342,0.012763883,-0.013057504,-0.02572163,0.04353187,0.059666704,-1.97393e-08,0.034387335,-0.042407658,-0.017266393,-0.05341806,0.0030454104,-0.033281162,0.0018328573,0.04114239,-0.0010245418,0.0034099957,0.105255656,0.07153062,0.07342557,-0.02208054,0.052047204,0.0037287027,0.0466673,-0.010488895,-0.10586606,0.006744666,-0.006008082,-0.036029752,0.07480701,0.041515373,-0.09146326,-0.0026919406,0.026999692,0.029540103,-0.04008852,0.0052366112,-0.0074666003,0.052771866,-0.008555939,-0.101797864,-0.09499066,0.08327196,0.025495103,-0.06874891,0.072023265,-0.041129574,-0.0054252674,-0.09297446,0.027027786,0.07578042,0.013645619,-0.03110745,0.010131961,-0.021313664,-0.03810174,0.0107457405,0.007368121,0.002556764,0.0057472056,-0.0039260383,-0.09749445,-0.022049794,0.0068670237,0.067804605,0.048879158,-0.016826868,0.0131299095,0.022896674,0.05616782,0.013883768 +4.1.2.25,"The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyse the epimerisation of the 2' hydroxy-group (EC 5.1.99.8, 7,8-dihydroneopterin epimerase) [2,3]. The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyses EC 5.1.99.8 and EC 1.13.11.81, 7,8-dihydroneopterin oxygenase [6]. The enzyme from the yeast Saccharomyces cerevisiae also catalyses the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3, 2-amino-4-hydroxy-6-(hydroxymethyl)dihydropteridine diphosphokinase, and EC 2.5.1.15, dihydropteroate synthase 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+4.1.2.26,A pyridoxal-phosphate 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+4.1.2.27,A pyridoxal-phosphate 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+4.1.2.30,"A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter [2].",384,1.0,-0.016164253,0.007184885,-0.040721964,-0.054422643,0.03983909,0.02053187,-0.062817715,0.005135055,-0.02152157,0.039462436,0.016887039,0.056478553,-0.050225362,0.022346236,0.027885128,0.06838988,-0.027318025,0.007412917,0.053619433,-0.0005704426,0.027373236,-0.03278962,-0.099808015,-0.04175417,0.061366625,-0.07985674,0.03706447,0.03497654,-0.09829174,0.030295549,0.024992086,0.0028470675,0.04597207,-0.0571254,-0.009112282,0.05939952,-0.075169094,-0.07565795,0.11129162,0.046647128,0.02182023,-0.05359418,-0.063167006,-0.0051761116,-0.044852592,-0.032229267,0.028797917,0.03663475,-0.04859391,0.061258595,-0.027550694,-0.020905107,-0.0372378,0.089913085,-0.025576012,-0.06467734,-0.08249906,-0.02465755,-0.019913925,0.003601041,-0.09326516,-0.0016343042,-0.06824285,-0.016818438,0.050901357,-0.058255415,-0.002306313,-0.0052373987,-0.03151438,-0.06143308,0.038787004,-0.016425513,-0.0036407537,0.043970805,-0.045082793,0.02957399,-0.013091132,-0.008822882,0.06539321,-0.030901566,-0.038530003,-0.009890139,0.0018946639,0.11096957,0.06543464,0.007180858,-0.021500345,0.09040527,-0.03624287,0.10656771,-0.017665079,-0.07204623,0.013121698,0.016522234,0.025224257,0.026849505,-0.019413836,-0.028638458,-0.013630938,-0.0005674234,-0.03515986,0.010231455,-0.007594093,-0.043178916,-0.057707258,0.06880805,-0.0049008485,0.051724892,0.037884373,0.015673546,-0.027494503,-0.020120448,0.0016612061,0.056380685,0.020563545,0.07948911,0.08376351,-0.011151621,-0.035563234,-0.07266305,0.017597351,0.052049167,0.1254333,0.041786842,-0.026294785,0.010077226,0.002968475,3.0433066e-33,0.06948863,-0.05429585,0.03940361,0.0153737385,-0.03495435,0.15241586,-0.058461897,0.05489211,0.040197976,-0.05745029,-0.0744525,-0.057935283,0.049035624,-0.040449813,-0.008974868,-0.042900283,0.053059876,-0.05535246,0.13781849,0.038284343,-0.044471063,0.056583773,-0.061512776,-0.014908157,-0.01834468,0.02499686,-0.024619991,0.051829994,0.0045260973,0.018821353,-0.07883757,-0.108067214,-0.0002185899,0.03424361,0.00054874626,-0.042038962,-0.053075414,-0.08271564,0.011701762,-0.020040054,0.023005193,-0.03795565,-0.003173269,-0.07986631,0.045497976,-0.008226815,-0.03933642,0.009112507,0.008248106,0.03403087,0.0035898162,0.05667764,0.07770709,-0.026366336,-0.09325135,0.06432235,-0.025443193,-0.033036362,-0.016795412,0.08213487,-0.009326225,0.06829379,0.028818589,-0.033181507,-0.0054050637,0.0049100053,-0.03473254,-0.08066025,-0.08903556,0.0871183,-0.03095752,-0.0017080621,0.07579603,-0.03440569,0.030145489,0.034751877,0.005061176,0.050826695,0.019994773,-0.0836514,0.0071848277,0.076574415,-0.03594736,0.03431523,-0.03006475,0.09086627,0.017475069,-0.07472518,0.09446501,0.049748924,0.023002623,-0.12324285,-0.047257286,-0.014719496,0.048430935,-4.035132e-33,0.041666426,-0.14104055,-0.0058598174,-0.08635895,-0.013196062,0.055963233,0.09794,-0.042155985,0.00034133144,-0.024131913,0.027421953,-0.10345787,-0.061824173,-0.09351119,0.053385254,0.008629271,-0.061419602,0.07117234,0.0077413474,-0.03571375,0.01098265,0.1111445,-0.00800057,0.11144002,0.071857885,-0.022383945,0.030469285,0.0068862783,0.091759615,0.10771114,-0.03844494,-0.014162391,-0.0288884,-0.03903621,0.07695456,0.07284078,-0.089732744,0.076906554,0.0496431,-0.01891054,-0.03327336,0.014957021,-0.007016027,-0.010634973,0.019941408,0.0837148,-0.049585667,0.03889037,-0.015334495,0.037235517,-0.026438147,-0.0101807825,-0.076229684,-0.060979318,0.008657832,-0.00046924208,0.03747875,-0.010592397,0.05617335,-0.06073311,-0.014021096,-0.053199157,-0.049497664,-0.027992433,-0.017321853,-0.0041159154,-0.049868528,0.030254127,0.043559194,0.054290365,0.095723495,-0.013422683,0.01983121,0.02582088,0.042244907,-0.020478185,0.008642114,-0.08409767,0.004409298,0.008344316,0.03490256,0.039597757,-0.021323113,0.02890087,-0.05247913,-0.061599586,0.01461753,0.100689314,-0.020498376,0.028485555,-0.023790287,0.022559926,-0.08254286,0.019097453,0.01865577,-4.67756e-08,0.011201504,-0.038972195,0.007425419,-0.012079997,-0.025620567,-0.024819542,-0.0038696649,-0.02579945,0.08958051,-0.027297134,0.0027156223,0.104913704,-0.009979939,-0.009507377,-0.014823468,-0.038363803,0.012066573,0.045241896,-0.010255376,0.0009202675,-0.030238504,0.020410735,-0.13858646,-0.004697411,-0.032287616,-0.0887351,-0.031057427,0.03663366,0.057639346,-0.028988158,0.04989648,-0.004288006,0.03548809,-0.06495795,-0.00598558,0.024333155,-0.025108567,0.012737957,0.097785085,-0.025183337,-0.005948807,-0.071999334,0.005823636,0.037341435,0.014043917,-0.035573047,0.025015771,0.021292647,-0.024276242,0.025812473,-0.013374476,0.039272644,0.052134316,-0.049898114,0.0089682555,-0.051536318,-0.048227295,-0.117448635,-0.009973971,-0.060806386,0.017563656,0.033654552,0.20009944,-0.009452175 +4.1.2.33,The insect enzyme is involved in the conversion of sitosterol into cholesterol.,384,0.9999999,-0.061700713,-0.0429885,-0.09309197,0.051438797,-0.07778655,0.032657646,-0.11342232,0.0120428195,-0.013011573,-0.04288682,0.012939445,-0.07523579,-0.08381827,-0.0788625,-0.039209835,0.027991412,-0.009578856,0.003112664,0.028689913,-0.050380502,0.024477743,0.033552144,-0.04059867,-0.010179689,-0.026161335,0.007776202,0.0027308466,-0.051222876,-0.037267476,-0.097805515,-0.0071116947,-0.027399844,0.075997986,-0.05776067,0.033471633,0.027868973,0.0017539453,-0.061738923,0.07898514,-0.02494946,0.10347345,-0.035665784,-0.043201365,-0.029778104,-0.03721012,-0.03346621,-0.016132088,0.07302471,0.021242829,-0.010631492,-0.09257097,-0.08484773,-0.04225918,0.0041568186,-0.032347903,0.031127922,0.031019723,-0.042304903,-0.004285029,-0.009602679,-0.00093890255,0.03435322,0.02992101,-0.011462787,-0.023946205,-0.10167729,-0.026898157,-0.055222277,0.048100773,0.025724802,-0.08512992,-0.04556409,-0.046840698,0.031885665,-0.028339928,0.016029608,-0.044825394,-0.08487035,0.082921326,-0.01950288,-0.004079938,-0.019187018,-0.025878383,0.09033318,0.07813749,0.04682997,-0.014464452,0.039394133,-0.030529315,0.017469585,0.051141944,-0.054138318,-0.028314508,0.008849743,-0.027235407,-0.023394575,0.0060468223,0.029844278,0.014443429,-0.010842082,0.01102445,0.03978912,-0.03806229,-0.089919746,-0.10198506,-0.0505107,0.06544383,-0.0077889096,0.044888575,-0.018299313,-0.039476197,0.027826041,0.04214028,0.025134161,-0.060820725,0.051336292,-0.025253562,-0.11936402,-0.026022641,0.06672967,0.054788608,0.007335644,-0.03634352,0.023416873,0.050270483,-0.046719786,-0.04081739,-2.3644661e-33,0.041271817,0.027396213,0.06345636,-0.01804739,-0.04304865,-0.0071597635,-0.07870438,0.07027768,0.05237433,-0.014841281,-0.01092424,-0.11427065,0.061400875,0.062319364,-0.008902456,0.0015224193,-0.009196847,0.04624222,0.117175706,0.0014187512,-0.046099782,0.02972085,-0.07579794,-0.024454357,0.029454965,0.09359448,-0.056718178,0.015728632,-0.019502098,0.027719995,0.07168128,-0.08350729,-0.06348743,0.070834905,0.07173515,0.083949335,-0.0031126589,-0.07587799,-0.116565816,0.077724315,0.02879062,-0.03495572,-0.02661123,0.032075707,0.014629083,0.02709999,-0.1147745,0.036125764,0.070234075,0.003755882,0.005339547,0.015307858,0.17272772,0.029283788,0.05495519,0.03350072,0.02104631,-0.012126433,-0.02805519,-0.0010745924,0.005558326,0.062245846,-0.058670633,-0.008512119,0.017482758,0.01851513,-0.070389874,-0.059257388,-0.06653818,0.062441386,0.04457893,0.0270095,-0.059086364,0.015181407,-0.026385717,0.047794376,-0.046541605,0.05855597,-0.0339867,-0.022257011,-9.548123e-05,-0.08129276,0.042371158,-0.09559082,-0.03232938,0.015309987,-0.008634975,0.009441541,0.027952468,0.039265685,0.04657394,-0.094637126,-0.054813262,0.01783424,0.015819164,-2.6011068e-34,-0.09503421,-0.059988234,-0.026397552,-0.020965427,-0.0648205,0.06273189,-0.047295522,-0.009543104,0.014988073,0.015989134,-0.005121532,0.07094307,0.027497096,-0.056610573,0.04425437,0.090313,-0.020857032,-0.01803773,0.018912775,-9.832687e-05,-0.04106753,0.12367437,0.087206155,0.11432403,0.05500791,0.042240277,0.10020376,0.026797436,0.034285124,0.051668297,0.053045146,-0.04817212,-0.01116657,-0.049164254,-0.07490745,0.04162405,-0.07601795,0.017310385,0.028248526,0.025354115,-0.07031509,0.0028445802,0.03622312,-0.050669476,0.022053432,0.00040663633,-0.04676716,0.012937081,0.022517562,-0.046729527,-0.0015790815,0.061286777,0.033343088,0.02441908,0.017534913,0.072237946,0.0018007179,-0.008340634,0.056358237,-0.13196135,-0.060774084,-0.011079252,0.0153480405,-0.020033548,0.009933076,0.051603913,0.020003874,0.007242528,0.009440186,0.005637985,0.019778727,0.07159656,0.017918075,0.11505953,-0.056377888,0.024127733,0.05045509,0.02193242,0.006840991,-0.070138134,-0.075915076,-0.0098607335,0.07190144,-0.10974644,-0.038884234,-0.059674736,-0.074564606,0.057441816,0.015786268,0.015402383,-0.016549226,0.01390093,-0.077160984,0.048849322,0.03399288,-2.084929e-08,0.055137627,-0.09992123,0.01355976,0.008918956,-0.031061199,-0.015049507,0.0052797785,-0.029536286,0.07339924,0.06416738,-0.057881642,0.11425466,0.11344714,-0.007467913,0.0421122,0.003147036,0.004085167,-0.017766183,-0.025167817,-0.021254217,-0.038443558,0.013769513,-0.058272026,0.027590472,0.0538778,-0.07641189,0.03696232,0.021804402,0.012715223,0.0020637598,0.009967857,0.08224109,0.032338914,-0.02148742,-0.03841922,0.06682276,0.018561913,-0.041190956,0.0014599315,0.07939024,-0.0121623445,0.0135421185,-0.011684477,-0.03216383,-0.055031545,-0.038530882,0.037263986,0.041096833,0.04507145,-0.030104687,-0.053021785,0.04858557,-0.0071421526,-0.007083321,-0.0697039,0.0007949577,0.013799066,-0.06471228,-0.0029533058,0.024672884,0.044283617,0.012372976,0.17459135,0.062943466 +4.1.2.34,"Involved, with EC 1.13.11.38 (1-hydroxy-2-naphthoate 1,2-dioxygenase), in the metabolism of phenanthrene in bacteria.",384,1.0,-0.06733488,-0.008599118,-0.04824541,-0.019816386,0.011408036,0.008468085,-0.08271214,0.035164785,0.041018687,-0.04403671,0.05271557,-0.11074191,-0.009556263,-0.0028008656,-0.056014966,-0.045619454,-0.07480217,-0.021458916,0.027574373,0.0225473,0.024444353,0.051904157,0.049951345,-0.016247736,0.030418001,0.032796536,0.03347456,-0.039665915,-0.03226201,-0.039094172,0.07355579,-0.09523696,0.021516869,-0.014906738,-0.033527937,0.080402635,-0.007790871,-0.069159344,0.078529455,0.07669547,-0.0029649783,0.035772506,-0.03442075,-0.044520203,-0.005014467,-0.027703693,-0.04110528,0.098566905,-0.019245248,-0.008665414,-0.063113794,0.048352323,-0.035900824,0.06222983,0.057339627,0.00065078563,-0.034271464,0.01993954,-0.029714702,0.0170375,0.005002052,0.0048359293,0.033255,-0.014514202,0.023311868,-0.10824492,0.014481788,-0.068248756,0.022589685,-0.080483146,-0.104357064,-0.028231995,0.06243712,0.024124976,0.00080624747,0.07151833,-0.0054625664,-0.045717474,-0.015433506,-0.033660967,0.03692789,-0.05352304,-0.0114049455,0.049120568,0.030082168,-0.025868377,0.015867243,-0.019030726,0.012103525,0.0837685,0.04462211,0.016542844,0.031136915,0.019416614,-0.034490544,-0.020302879,-0.008790772,0.08435071,0.029135913,-0.02913534,-0.053261537,0.041968435,-0.09169454,-0.054660868,-0.091442645,-0.08255557,0.04863638,0.11809227,-0.0014386693,-0.086748086,0.07597386,0.0072214752,0.038496353,-0.01937551,0.032730326,0.09681929,0.067417696,-0.09345685,-0.09579168,0.018916756,-0.043327477,-0.10953468,0.012459172,-0.011210036,-0.050120384,-0.021282034,-0.03292129,-9.363419e-34,0.08665422,0.026866205,0.021513436,-0.030027008,0.0030416043,0.0095538,-0.122911945,0.010842002,0.011234546,-0.13791054,-0.0026238824,-0.071428604,0.017534846,0.01798731,-0.026274774,-0.043881945,0.0026028363,-0.0022703994,0.09976385,-0.038358577,0.010077626,0.00064284005,0.03392997,0.006113209,0.02984484,0.044465184,0.02437608,0.023932096,-0.07455622,-0.00041167,0.0640487,-0.14250973,-0.08076334,0.036990758,-0.029517042,-0.024616392,-0.06924912,-0.047175866,-0.026650479,0.009546938,-0.05284965,0.036047563,0.05527724,0.018668907,0.007962646,0.011067801,-0.003891267,0.14875785,0.056850813,0.06384884,0.020628933,0.0012928786,0.11981325,-0.07717707,-0.045320306,0.056717362,0.00576321,-0.04708397,0.089542314,0.07182531,0.051851813,0.119449995,-0.024192112,0.026248066,-0.026536006,0.036321618,-0.063690044,-0.015607623,0.02076083,0.076298766,-0.05427077,-0.027772918,0.101496816,-0.002828916,0.032642208,0.03009326,-0.058180187,-0.005575406,0.0069112983,-0.03275225,0.03494662,0.025862707,0.02786662,0.0524865,-0.03775284,0.023499012,-0.0340585,0.03204911,0.020306397,0.10377622,0.09062069,-0.07689914,-0.07508644,-0.038697965,-0.0047678854,-2.1397482e-34,0.014665398,-0.036610898,-0.09819975,-0.06488194,0.0055016787,0.04648433,0.00012136652,0.03468875,-0.015446018,-0.032118034,0.1138197,0.014466032,0.0039821602,-0.018764831,0.07529891,-0.01947026,0.042708907,0.008201414,-0.012844801,0.026982555,0.0386042,-0.050079543,-0.041444466,0.02065385,0.074828245,0.06547299,0.010267591,0.036999412,0.031330932,-0.013772615,-0.044886857,0.03772074,-0.025100525,-0.03336716,0.031847607,0.07167497,-0.027402902,-0.04020993,0.0024267496,-0.01695401,-0.0010193782,-0.03131699,-0.034750547,0.021817569,0.056471597,0.05004254,-0.001315697,-0.04043883,-0.025786381,-0.0073729306,-0.04734121,0.087959975,0.03298433,0.0031360837,0.044109467,0.03243102,-0.055737603,0.027324073,0.085326135,-0.043384727,0.007956102,-0.10010603,0.00044445088,0.019706806,-0.031425882,-0.055754513,0.0029493254,0.02411621,0.046815325,-0.008869492,0.087606415,-0.03848212,0.07864644,-0.016039811,-0.1322882,-0.019270042,-0.0147452615,0.0006363452,0.0067781843,0.07680979,0.008918439,0.0038115806,0.037637126,-0.1134876,0.022657389,-0.06720856,0.07142962,0.03582161,-0.050008323,0.010182235,-0.0030968594,-0.039974153,-0.05382557,-0.0140942475,0.02031328,-3.068469e-08,0.04544336,-0.10199445,0.07457383,-0.001214302,0.057184868,0.001282287,0.007415954,0.022680728,-0.033764403,-0.0005505251,0.06461239,0.061421745,0.053282015,-0.017922053,0.021139406,0.019319149,-0.070757076,-0.033602335,-0.030656796,0.031439427,-0.06666878,-0.026730368,-0.12925425,0.035248607,0.036127504,-0.020963393,-0.02909868,-0.041540295,0.009058371,-0.08090221,0.052513856,0.037746213,0.042231906,-0.067861415,-0.0754559,0.011225199,-0.03382225,0.042612374,-0.04170678,0.0127659235,-0.014944189,-0.039201654,-0.031081617,0.057351995,0.08645842,0.09880461,-0.013428695,0.03617551,-0.061727468,-0.06040087,0.017180638,-0.034445494,0.00070566614,-0.006498128,-0.10485145,0.01466311,0.0056741857,-0.08796801,-0.029606082,-0.03074616,0.03752848,0.051190626,0.14749046,0.02111608 +4.1.2.37,"This enzyme accepts aliphatic and aromatic hydroxynitriles, unlike EC 4.1.2.11 (hydroxymandelonitrile lyase) which does not act on aliphatic hydroxynitriles. 2-Hydroxyisobutyronitrile (acetone cyanohydrin) is liberated by glycosidase action on linamarin.",384,1.0,-0.05135201,-0.05435489,-0.051886912,-0.060943626,0.044774108,0.02992108,-0.08798022,-0.024498371,-0.04961089,-0.10365654,0.068530776,-0.018759193,-0.05020471,0.005037765,-0.051691715,0.021631379,-0.020031424,-0.004430774,-0.042895664,-0.032686114,-0.032451812,-0.06801839,0.003527438,0.0021420766,0.020639045,-0.015761428,0.016244495,0.011228466,-0.014731148,-0.079272784,0.042566158,-0.052092474,0.014776706,-0.019230906,-0.014215217,0.056120567,-0.053500008,-0.07100317,0.020096928,-0.020814145,0.06086051,-0.07072702,-0.03261313,-0.05360212,-0.008554445,-0.10555535,0.00550403,-0.046151333,0.010631869,0.042282116,-0.009326323,-0.06885085,-0.017752763,0.041439246,-0.0038551607,-0.025332095,-0.075175054,0.011490046,-0.003908376,0.09677486,0.01876986,0.046839602,-0.0662051,0.01816313,-0.08207366,-0.054137632,0.05214098,-0.060426373,0.017136324,-0.028195655,-0.0045443773,-0.086751536,-0.036732003,0.07903034,0.011732208,0.030089885,-0.038489774,-0.078232445,0.021937732,-0.038522087,-0.0132568525,-0.0113768745,0.044831622,0.08565765,0.025173988,0.009971335,-0.0847702,0.009087766,0.0013983208,0.039903585,0.086848654,-0.004498501,0.026902076,-0.060857944,0.032274075,0.04609236,0.0867523,0.016861597,-0.053667374,-0.0007610969,-0.029421937,0.06765243,-0.111090615,-0.08785615,-0.033857867,0.042665496,0.06907109,-0.010108242,0.054163676,-0.039936572,-0.029271401,-0.058841366,0.03657623,-0.06337173,-0.08219133,0.07430656,0.016232353,-0.007659892,-0.024827309,-0.033127632,0.0006989975,-0.004058549,0.06582076,0.06885999,-0.013576609,0.037319094,-0.04722319,7.906176e-33,0.09928066,0.0079497285,0.023180109,-0.0024448407,-0.017894832,-0.0054759174,-0.11607035,0.01224973,-0.03594888,-0.07843961,-0.04877359,-0.029147992,0.012167129,0.06720384,-0.01024986,-0.004269632,-0.048338596,-0.027762469,0.064535365,0.0036217533,0.07583393,-0.020523453,-0.086504065,0.016034424,-0.034909543,0.007953935,0.041023046,0.09945643,0.057688486,0.031882398,-0.03826733,-0.05865426,-0.079357125,0.044616517,0.004024188,0.048705712,-0.05746785,-0.037399247,0.029284753,0.025387952,-0.068437815,0.031711172,0.023210563,-0.0886019,0.033335835,0.010410862,0.007744571,0.04883637,0.11052864,0.016815186,0.042897455,-0.03992603,0.0740031,0.041766215,-0.0072716842,0.12495578,0.007730593,0.064800784,0.03603359,0.05845355,0.050051074,0.053433727,0.031289674,-0.04997307,0.029634733,0.101187274,-0.062785126,-0.053578045,-0.043807354,0.002162916,-0.030483268,-0.011115939,0.09910106,0.049052473,0.14521942,-0.049676456,-0.0021645364,0.035267845,0.03726839,-0.010407486,-0.023174075,-0.024023077,0.04214883,0.019620558,-0.041389845,0.019209614,0.0013762382,-0.0038562024,0.020998377,0.031376984,0.032008987,-0.06924578,0.012737159,0.039125226,-0.006752498,-8.706319e-33,0.07435662,-0.05163159,0.04933005,-0.062716655,-0.03809447,0.04782464,0.027538504,-0.018356387,0.01559646,0.053068176,0.15034851,0.015865218,-0.03212693,-0.030318622,0.022044595,-0.022818005,-0.03613828,-0.032075167,0.020485371,0.035014726,-0.0070535704,0.023861067,-0.018543852,0.033424173,0.08355664,-0.035113562,-0.011491116,0.043228216,0.06901974,0.038902458,-0.10747788,0.029348604,-0.0649801,-0.049823076,0.0020522834,0.055878,-0.06033775,0.030468078,-0.0642233,0.024711577,-0.0013063254,0.003264343,0.010380166,0.09191114,0.102921635,0.07281504,-0.080878586,-0.008910907,-0.02240486,-0.039913904,0.0034113727,0.0810243,0.0070405463,0.062230248,0.06685737,0.079085134,0.04931926,0.03986019,0.015749633,-0.05123396,-0.065398365,-0.036918163,0.015775869,0.015375962,0.018129513,0.06662237,-0.061969105,0.051343586,0.012063182,-0.022263365,0.059326716,-0.0863672,0.09771303,0.04096469,0.034320068,-0.0025453176,-0.0147525,-0.092232354,-0.089365646,-0.06426137,0.0876449,0.00930587,-0.019603575,-0.08012708,-0.037138745,-0.029316502,0.0027290918,0.075455956,-0.05992386,0.02981932,0.0117362905,0.056798488,-0.02154282,0.027689325,0.047939435,-4.4611223e-08,-0.0072301067,-0.04742233,0.069041304,-0.08744169,-0.022781102,0.017799474,-0.015238554,-0.009377417,0.0177943,-0.06068587,-0.05282612,0.08594736,-0.024218144,0.0067942394,-0.022671567,0.009349767,-0.021596054,0.026943492,0.0097873,0.05802767,-0.087288976,0.023457896,-0.12736982,0.0027699354,-0.066900596,-0.011653042,0.0030636177,0.06544055,0.00534911,-0.04693326,0.04016578,0.07237328,0.007146519,-0.01872136,-0.08984526,0.024624,-0.089608826,-0.0158501,0.0019228354,-0.022150928,-0.01573981,-0.03514882,-0.060848,-0.016156903,0.056715388,-0.0101251155,0.06983091,0.003769284,0.027883586,0.025053808,0.04990932,-0.10027392,0.045899406,-0.12202414,-0.018772725,0.003389398,-0.042041216,-0.08902294,-0.008668044,-0.061274737,-0.014935287,-0.05336621,0.18070462,0.0019795652 +4.1.2.38,A thiamine-diphosphate protein.,384,1.0,-0.08089331,-0.008508355,-0.052845582,-0.008935192,-0.0099549685,-0.008899688,0.08867158,0.06044833,-0.010204869,0.030642731,0.026736205,-0.048694246,0.006689777,0.0569292,-0.01152731,0.015394125,0.011099636,-0.041505013,0.020707866,-0.049765196,0.005178324,0.12267674,-0.065429695,-0.021972936,-0.021461753,0.067434385,0.059812415,-0.013213148,0.0037130846,-0.08659743,-0.12188814,0.012667931,0.03196427,-0.04269946,0.03154372,0.06594522,-0.049162738,0.006926556,0.01582329,-0.033747587,0.126263,0.011330333,0.03322762,-0.018699003,-0.0757644,0.004035201,0.07852067,0.081025325,0.05880025,0.06895604,-0.061526455,-0.025555525,0.030837726,0.01387693,0.03475142,-0.044965696,-0.028472142,0.012775305,-0.03833213,0.026187284,-0.015264927,-0.042473573,-0.008844242,-0.04815847,0.17117983,-0.09913953,-0.008820532,-0.017523,0.04000238,-0.050130356,-0.032900088,0.021681247,0.051384714,0.035435114,-0.053553376,0.046780013,0.022324312,-0.030239535,0.069951884,0.012469383,0.008797224,-0.012904543,0.026385494,0.087267354,0.039287515,-0.030835873,0.01601314,0.045591533,-0.039443683,-0.05858424,0.018343266,0.009375835,-0.033803824,-0.0018618377,-0.104120106,0.03737714,0.00797313,-0.038440265,-0.07663245,0.026142927,0.08903679,0.020288698,0.0021568767,-0.058109432,-0.023168389,-0.018907152,-0.0023633735,0.04043457,-0.0017141431,0.040040616,-0.0026129305,0.040709913,0.045801893,-0.008293402,-0.042716052,0.017800042,0.010991428,-0.005722406,-0.04034189,-0.056963768,-0.04982591,0.026854457,0.036847793,0.034382503,-0.04761617,-0.03355186,-0.095208116,-2.2230784e-33,0.07071541,0.0539216,0.043020967,-0.017484106,-0.0184938,-0.011922019,-0.038998317,0.04833572,0.0014333928,-0.028858704,-0.020961048,-0.08400749,0.084453315,-0.009150999,-0.038594477,-0.09061495,-0.033317626,0.007078118,0.10663654,-0.046077006,-0.086670324,0.102290966,-0.06016048,0.022663027,0.01470431,0.0074642515,0.0061687194,0.03498647,-0.012059062,-0.0070122755,0.07563373,-0.05090983,-0.09404059,-0.07193445,0.0735814,-0.09375284,-0.028330285,-0.031441115,-0.069042675,-0.032223415,0.054083128,-0.0051815226,-0.029613292,-0.0144490795,-0.0033177834,-0.108701035,-0.03704339,0.034042478,-0.049540874,-0.006718976,0.02695159,-0.03760962,0.11432143,-0.05953667,-0.07911482,-0.026610846,0.010236068,-0.001361554,0.04803166,0.053076603,0.011230352,-0.0054337056,-0.13221513,0.062162194,-0.07170701,-0.0073548863,-0.12419155,-0.040874053,0.061654046,0.06484494,0.057801176,-0.020916007,0.07116711,-0.032153543,-0.07804834,-0.03471738,-0.045287777,0.05918875,-0.023804752,0.04823427,0.095876224,-0.038004152,-0.007299276,-0.02754372,-0.10930528,-0.032703955,0.09118197,-0.04138834,0.01619424,-0.03557237,0.05025907,-0.027462415,-0.061526995,-0.03263133,0.021615144,4.262859e-34,0.08965645,-0.08797283,0.04366342,-0.03858394,0.0033453282,-0.057531007,0.08571825,0.0088385735,-0.039410986,-0.051010437,0.10090465,-0.013583042,0.040143583,-0.05494334,-0.0004678554,0.12240701,-0.03752116,0.059963718,0.06787214,-0.014212277,-0.06711342,0.039587617,0.059169386,0.047719896,-0.035512965,0.025131794,0.03382383,0.0031276224,-0.039735194,0.100473315,-0.020388402,0.025186416,-0.062149014,-0.028382156,-0.091326736,-0.032251753,0.013432346,-0.087447256,0.0033955716,-0.00887085,-0.038586818,0.05670098,0.07864567,0.088383384,0.06332793,0.06600844,0.013713473,-0.019107353,-0.07996807,-0.018728126,0.04630545,0.010541479,0.007797401,-0.0075894357,0.025498688,-0.04259823,-0.036016036,0.02011304,0.042991944,-0.007973789,0.004900771,-0.08420613,0.00014969216,-0.000714559,0.036420736,0.08642689,-0.023579342,0.028929364,0.07375894,0.003395215,0.050824087,0.045550715,0.09741437,-0.029638162,-0.031944513,0.062842816,0.0016379859,0.07843737,-0.035189476,-0.0027150498,-0.03261278,-0.027323106,-0.064616755,-0.019386083,-0.003614757,0.009034124,0.040507123,0.053434446,-0.05227944,0.050296094,-0.09876313,-0.017010696,-0.040309936,0.09723824,0.105813116,-1.7993957e-08,0.028785702,-0.09492228,-0.025458025,-0.032958154,-0.018395964,0.084619135,0.013415192,-0.00010479627,0.1102944,0.039328806,0.023878831,0.0416585,-0.017178888,0.05973567,0.06453927,-0.018341351,-0.024615066,0.0040614037,-0.016355202,0.00702142,-0.010834695,0.0111402795,-0.0012487716,0.009495611,0.022178067,0.027372165,0.0017497846,-0.047776826,-0.0210248,-0.06116085,-0.00033317087,0.030861108,-0.012133413,-0.09617541,-0.01069815,0.07840893,0.0542489,-0.030803885,-0.05276984,0.017684039,-0.0050797258,0.02509206,-0.109584905,0.006026348,0.012833139,-0.020215685,0.013186039,0.119689025,-0.05961564,-0.07459989,-0.04184507,0.020418046,-0.012473562,-0.041026995,-0.051568758,-0.00893825,-0.055236664,-0.01527889,-0.045739975,0.02272791,0.042370535,0.02054589,0.07977227,-0.0334902 +4.1.2.39,"The enzyme from Hevea (rubber tree) and Manihot spp. (cassava) accepts aliphatic and aromatic hydroxynitriles, unlike EC 4.1.2.11 (hydroxymandelonitrile lyase) which does not act on aliphatic hydroxynitriles. 2-Hydroxyisobutyronitrile (acetone cyanohydrin) is liberated by glycosidase action on linamarin.",384,0.99999994,-0.002244413,-0.040855575,-0.07016384,-0.040011458,0.044150133,0.089065135,-0.057646785,0.022339124,-0.056845866,-0.036838982,0.043546308,-0.023949822,-0.02956046,-0.011879543,-0.042006858,-0.022424867,-0.0118162315,0.0036889822,-0.020845646,-0.025725938,-0.0024823274,-0.06376865,-0.006254823,-0.057884086,0.04022794,0.042608924,0.021856928,-0.045134835,-0.06066017,-0.13258028,0.016246486,3.2610085e-05,0.017932145,-0.08877748,-0.017813751,0.050717916,-0.006282921,-0.05367054,0.07597151,-0.013778842,0.055769913,-0.029385233,-0.03126939,-0.08738694,0.012900456,-0.10370935,-0.004475871,-0.03560268,0.03293978,0.024019904,-0.08571815,-0.03822641,0.0018285036,0.044206794,0.022551391,-0.039561175,-0.02701496,0.013803872,0.025136579,0.1052943,0.015681012,0.019834748,-0.020962598,0.0046525854,-0.05858945,-0.0842729,-0.003828168,-0.01137069,0.01926041,-0.024945125,-0.030579284,-0.06010127,0.0032155367,0.10629458,-0.0021348153,0.058377307,-0.015387847,-0.018082384,0.031001179,0.0033499154,-0.077831,0.025323553,0.055788852,0.0762466,0.011582641,0.061516095,-0.052666776,-0.017619412,0.04463521,0.07173734,0.0517349,0.012362446,-0.001932167,-0.071857125,0.029822402,-0.007210405,0.07335627,0.0077613182,-0.067398734,-0.0025699872,-0.008945457,-0.04121698,-0.124651276,-0.0678399,-0.048090916,0.081753336,0.014925796,-0.050545238,0.14250569,0.010629145,-0.061601806,-0.025296388,-0.014154392,-0.11029031,-0.13200942,0.06393897,0.0021784431,-0.042961523,-0.03129894,-0.08457567,0.0025018079,-0.015971556,0.07185727,0.06678842,-0.0045917877,0.010238646,-0.025686476,7.248854e-33,0.06721346,0.014790644,0.04487953,-0.03597631,0.008977565,-0.044720013,-0.07814509,0.05613487,0.00044335081,-0.12025032,-0.1033192,0.0034890778,-0.035095148,0.06415928,-0.00470645,0.055899385,-0.015356661,-0.064188264,0.05435097,-0.053911127,0.04286956,-0.040603254,-0.099644616,0.04910501,-0.040484585,0.026862837,0.10481472,0.03961208,0.057607464,0.034496546,0.026709111,-0.08698074,-0.019923415,0.07326672,-0.0074472832,0.060344324,-0.039614163,-0.031114103,-0.045656376,0.070886575,-0.008133042,0.019579401,0.040891066,-0.040127207,-0.0036604751,-0.035423525,0.0013624548,0.03725365,0.06857756,0.018336374,0.013315893,0.023717714,0.087384276,0.0690763,-0.0053520575,0.121361025,0.00032255732,0.03927118,0.03923544,0.08369129,0.027023155,0.028649975,0.01295485,-0.049138106,-0.0034759652,0.11456608,-0.09057558,-0.036032893,0.00082248193,-0.014878528,-0.024725247,-0.012940713,0.04332321,0.06502123,0.106196135,-0.03749182,-0.012092144,0.04265918,0.03769082,0.016977848,0.0029583767,-0.006624095,0.029928036,-0.0035160144,-0.12749365,0.017007597,0.009522065,-0.03965973,-0.0063768043,0.03093244,0.033740144,-0.06272738,-0.0036437784,0.042181116,-0.018569037,-8.562952e-33,0.056946002,-0.03314879,0.013254986,-0.012612594,-0.029111242,0.029997258,0.022342155,-0.003198449,-0.025384076,-0.04300918,0.05968609,-0.02740357,0.008442393,-0.026701761,0.010545406,0.0038266033,0.019323185,0.023049774,-0.0029884789,0.025544455,-0.039179284,0.05860251,-0.00063217623,0.041864857,0.0653273,-0.06022483,0.05785225,0.0151095325,0.022405025,0.055239845,-0.01869725,-0.0057631163,-0.08636216,-0.025627106,-0.0028365336,0.061147135,-0.10702557,-0.020549688,-0.026260743,0.07376771,0.012137384,-0.03474523,0.018597428,0.08893671,0.070249975,0.07933892,-0.110324666,0.06401298,0.02752203,-0.014919509,0.05078287,0.059414964,-0.004368816,0.04149454,0.07990655,0.05171923,0.036149286,0.04329304,0.00583994,-0.02805694,-0.009287786,0.0028876744,0.03613219,-0.031701,0.033010054,0.0660789,-0.03830501,0.005245788,-0.012773071,-0.059159916,0.09162028,-0.11773307,0.09510056,0.06874006,0.0033758087,-0.018808566,-0.029551303,-0.060997277,-0.10419039,-0.07812008,0.08330432,0.003928462,-0.0015173503,-0.10288497,-0.022199258,0.03898255,-0.030539013,0.020437872,-0.042035796,0.09436921,-0.007864106,0.04790483,-0.041229032,0.067668505,0.07063801,-4.9547424e-08,0.03826538,-0.06268951,0.03994678,-0.030935718,-0.05233015,0.03287394,0.0014236545,-0.029394217,0.026939599,-0.05452941,-0.0770984,0.06625198,-0.015207866,0.026741276,-0.019014984,-0.015301061,0.039063893,0.045733914,-0.008685424,0.046145186,-0.11739405,0.0071885968,-0.09588147,-0.011857458,-0.062130474,-0.048410676,-0.0020222657,0.020494273,0.077790596,-0.012632746,-0.011770306,0.09595216,-0.0020018327,-0.048413925,-0.07646794,0.033023078,-0.07717257,0.0038872918,0.018569125,-0.021217752,-0.009550138,-0.032911442,-0.030996783,-0.023193674,-0.017227855,-0.017435873,0.029505929,0.021972638,0.012380168,-0.0049536875,0.036107145,-0.04882799,0.04039148,-0.08324436,-0.055843644,0.0124528585,-0.001170198,-0.11485646,-0.0030901784,-0.044891417,-0.040274587,-0.09096441,0.16245805,0.02734317 +4.1.2.40,Enzyme activity is stimulated by certain divalent cations. It is involved in the tagatose 6-phosphate pathway of lactose catabolism in bacteria.,384,1.0,0.062914655,-0.09245485,-0.06489841,0.033695094,-0.0022198677,0.08464593,0.0074346727,0.061690718,-0.011691146,0.004683952,-0.011743319,-0.009078433,-0.062338952,0.06934838,-0.023038117,0.020588037,-0.10349015,0.030632831,-0.051003583,0.0105293,0.11112482,-0.0057847416,-0.009038885,0.0068600737,0.056547135,-0.011920495,0.08482933,-0.038654786,-0.051147673,-0.029069982,-0.03459006,-0.022717914,0.071242176,-0.02094085,0.02974486,0.10893952,0.039087534,-0.04296618,0.05562635,-0.03188351,0.03388473,-0.03594859,0.018490152,-0.022833107,-0.019845849,0.0073751933,0.026322098,0.049484447,0.010849267,-0.037240148,-0.080329604,-0.06190645,0.022732532,0.015255224,0.01514506,0.051064502,0.005745424,-0.08790867,-0.006179537,-0.026540032,-0.036764327,-0.021370592,0.059559014,0.07079971,0.059253104,-0.059614334,0.039693907,0.021053933,-0.05412848,-0.041661076,-0.052724004,-0.05863281,0.023092283,-0.087692216,-0.027119512,0.0020321,-0.036304947,-0.046692442,0.0416934,-0.009953487,0.031103646,-0.09121833,0.004599599,0.0727338,-0.03977937,-0.045700345,0.08183552,-0.03339048,0.0669936,0.043716908,-0.0017740888,-0.016402297,-0.03856389,-0.09869471,-0.09839538,-0.052911315,-0.028906986,-0.01780531,0.06927273,-0.023001464,-0.0074051903,0.037951082,-0.035361752,-0.0005885295,-0.012553389,0.034597076,0.010282078,0.12952465,0.024925113,0.011629341,0.036022775,0.011394682,0.033262283,0.029135134,0.009414905,0.09541977,0.0860181,-0.091699295,-0.054825608,0.041027773,-0.03347018,-0.009495377,0.04147867,0.008807329,-0.071753435,0.0511602,-0.042082552,8.906458e-34,0.048053786,-0.037562154,0.036587603,-0.05873971,0.025241086,0.012251976,-0.071836375,-0.03701978,-0.049852856,0.0209166,-0.018085482,-0.049809456,0.065454654,-0.0076078326,0.035024107,0.029837677,-0.025702797,0.019148406,0.03954206,0.03023562,-0.0061610756,0.006658952,0.00013215216,0.009775444,0.036253825,0.09960023,-0.023151737,0.026551915,-0.019543435,-0.011387965,0.098047584,-0.050514888,-0.10173309,0.040377,0.055232406,-0.0035648544,-0.055700712,0.026258826,-0.011603534,-0.0143015385,-0.011291466,-0.039439637,0.004436384,-0.08521906,0.018794559,-0.056019135,0.0154411,0.07655335,0.022722874,0.08622792,0.053859577,-0.060682964,0.094056085,-0.061533038,-0.025117619,0.016745726,-0.02269374,0.016849915,0.051525377,0.06359433,-0.017045915,-0.021285584,-0.00096694595,0.0069858,0.059025787,0.021998888,0.037530098,-0.044870794,0.011340747,0.07822856,-0.099885575,-0.01568211,-0.0008024043,0.047481976,0.007547188,0.020602638,-0.09410162,-0.0697907,-0.013410576,0.02679921,0.0037954876,-0.110195644,-0.00315898,0.00081547635,-0.0635033,0.019063454,-0.10256517,-0.082192436,0.004053001,0.043942854,0.11532892,0.0031655186,-0.13208905,0.023416366,0.066188365,-3.103847e-33,0.16692312,-0.071719065,-0.02978852,-0.07537994,-0.0617887,0.010679868,0.045138773,0.042065326,0.016191673,-0.004062911,0.013048038,-0.002768735,-0.038389936,-0.017756453,-0.028712949,0.051347565,0.025004478,0.0871351,0.064411,0.018416584,0.031867225,0.092412665,-0.050428182,0.047828324,0.09665835,0.020969955,-0.013447689,0.035214163,0.009460673,-0.03543498,0.0013796865,-0.014071,0.01524958,-0.10170703,-0.032394256,-0.016292255,-0.019975103,0.013534196,0.07517883,0.037059415,-0.027362332,0.09019953,0.04135947,0.03748446,-0.029777871,0.01674091,-0.038393326,0.0053055515,-0.05741886,-0.03271844,-0.0060584876,-0.07204632,-0.009833716,-0.002505048,-0.007870842,0.04549833,0.009266481,-0.034456942,-0.040449403,-0.019908337,-0.011477561,-0.035178583,0.045881774,-0.058285918,-0.035837367,0.015784632,-0.053348202,-0.004096664,0.0019457188,-0.017879492,0.034201577,0.03214973,-0.021546584,0.034937646,-0.057799894,-0.0046758736,-0.089584075,-0.05870262,0.039004892,-0.046241205,0.009087514,0.019437727,-0.031837516,-0.049121648,0.030408975,-0.02983427,0.05232538,0.08394704,-0.017071242,0.014229178,-0.044186227,-0.025528885,-0.02381848,-0.008808962,0.0018136468,-2.8881738e-08,0.03432702,-0.09885171,0.007924286,-0.04058392,0.047739543,0.024467729,0.018049203,0.05471829,0.041217897,-0.030337743,-0.025334584,0.1073427,0.03230638,0.0012173924,0.016622305,-0.0051318207,-0.043620344,-0.08040179,-0.08871113,-0.010414092,-0.05996064,-0.056905754,-0.11829328,0.07619307,0.111921936,-0.034666613,-0.0042164726,0.06856937,-0.02345351,-0.038915444,0.06871307,0.044754464,-0.042965606,-0.040020604,-0.029263927,0.08377682,-0.0011067898,-0.15145886,-0.025303008,0.003312403,0.015276511,-0.042750943,-0.059146043,-0.045625858,-0.033652384,0.078717835,-0.056385923,0.007134167,-0.014360528,0.025775902,0.02869801,-0.045657795,-0.0690015,0.047628365,-0.021639645,0.042255946,0.065010585,-0.09258021,0.016901912,0.014404216,0.11167208,0.018487653,0.1684318,-0.14379704 +4.1.2.41,"This is one of the activities of a bifunctional enzyme, trans-feruloyl-CoA hydratase/lyase, that converts trans-feruloyl-CoA to vanillin. The other activity is EC 4.2.1.101 trans-feruloyl-CoA hydratase. Vanillin is converted to vanillate by EC 1.2.1.67 vanillin dehydrogenase.",384,1.0,0.0065989955,-0.0248831,-0.07625502,-0.07280473,0.1272667,-0.006444002,-0.048006922,0.0037921674,0.0073129293,-0.052762453,0.01430782,-0.09925424,-0.122221544,0.022606187,-0.01569775,-0.045164313,-0.03414053,0.048822228,-0.010210094,-0.028443422,0.06284161,0.0032657061,0.0026300116,0.026382377,-0.0019306163,0.011380523,0.059249785,0.01413247,-0.019283263,-0.09944692,-0.092839465,0.003603234,-0.0063502067,-0.04441255,-0.02874308,0.077866495,-0.043020032,-0.018140156,0.0514961,-0.036110453,0.051734917,-0.1250142,-0.0076552853,-0.09971027,-0.06132759,-0.034645956,0.020876052,-0.040564787,0.059830148,0.0048656375,0.059390105,-0.0198438,0.0022533552,0.041968007,-0.028220024,0.007153239,-0.04853564,-0.022954127,-0.018688967,0.019855576,-0.011690633,0.03318328,0.011502725,0.04170661,0.010515022,-0.07078515,0.055840854,-0.048741303,-0.022792215,-0.07600777,-0.028471783,-0.06518357,0.00205337,0.03714476,0.012462139,0.07345031,4.8364927e-05,-0.026808146,0.02819595,-0.040276088,0.048181318,0.03819712,0.044016954,0.037500277,0.015086047,-0.03671506,-0.004415504,-0.030525906,0.05449365,0.04740152,0.023678996,0.049971335,-0.027972147,-0.03454739,-0.029236864,0.031202424,0.052616704,0.033456534,0.07953163,-0.023732847,-0.038896464,0.176517,-0.03463707,-0.1015669,-0.0005432451,-0.002091738,0.006987452,0.09554946,0.020498805,-0.039148618,0.035230234,-0.08490354,0.11899178,0.051169734,-0.016431531,0.0073778313,0.002092201,0.013358654,-0.09189909,0.10884592,0.034228418,0.011737729,0.06393013,0.088205464,-0.010648972,-0.0045093605,-0.04112792,2.3930205e-33,0.06539078,0.0039055613,-0.013896689,0.034887463,0.030600283,0.016947996,-0.13689089,0.057908352,-0.02672528,-0.024854876,-0.08503721,0.0074546244,0.038389716,0.06927526,-0.02665871,-0.057073254,0.052295934,-0.018927678,0.06657244,0.01207144,0.044136062,0.0957128,-0.036270726,0.044498295,-0.017403264,0.07140233,-0.0014745628,0.026762173,-0.003362113,0.007749086,-0.052163593,-0.079393156,-0.0211746,0.015956596,0.023398895,0.011559217,-0.036147635,-0.04544556,-0.010733651,0.027679766,0.03847475,0.029225012,-0.011272915,-0.10988518,-0.04547349,-0.022510253,0.010032968,0.09158164,0.03487245,0.042153217,-0.0062478455,-0.033128075,0.011322631,-0.09024424,-0.016083412,0.0049856347,-0.015142624,0.014142029,0.05543876,0.06360925,0.014960701,0.07318314,-0.046061065,-0.014568665,0.044187494,0.0026456835,-0.06173721,-0.1362412,0.021176932,-0.0699384,-0.062155213,0.033011034,0.09834814,0.021300182,0.084343635,0.013311775,-0.061813157,-0.02504318,0.050161023,-0.0046043824,-0.043412924,0.04240842,0.035188776,-0.017557096,0.012300062,0.0039305706,-0.04534882,0.0008026034,-0.054558758,0.0045127324,0.004823582,-0.097296044,-0.086918324,-0.036548857,0.061775796,-3.227438e-33,0.07925914,-0.062440068,-0.022027528,-0.06859794,-0.03556264,0.07609429,-0.031352058,-0.048713494,0.031732775,0.015437958,0.079169214,-0.024735754,0.05636758,-0.05000292,-0.0220554,0.027460244,0.0036188117,0.022879401,-0.046011984,-0.021252569,-0.07008525,0.09506063,0.028943682,0.04119971,0.10737806,0.0038111256,0.012696985,0.034758944,0.025148552,0.07522429,-0.06927205,-0.013745903,-0.002896396,-0.012428078,-0.027539454,0.07571708,0.032576956,0.029484762,0.06600417,0.0308966,-0.02387205,-0.017226527,0.015446629,-0.050975714,0.012118977,0.0052364417,-0.07236001,0.004025491,0.008142509,-0.031127853,0.052517556,0.031430945,-0.035698008,-0.0076810615,0.00056819915,0.06755225,0.06594776,-0.00019415007,0.0092285415,-0.041891266,-0.04266363,-0.016051192,0.024765424,0.0026849685,-0.03982222,0.044568677,-0.10104085,0.025267122,0.047502916,-0.041526645,0.13527088,-0.051075414,0.09888341,0.024209462,0.010999724,-0.11618459,0.04249748,-0.081995696,-0.00029051094,-0.077408224,-0.047507677,-0.062142182,0.011332733,-0.053417232,-0.08699135,-0.049533118,0.038142208,0.041498043,-0.03395619,-0.019178692,0.007371557,-0.0334074,-0.08264703,0.075030394,0.08783931,-3.6369013e-08,0.011385057,-0.03313086,0.036973402,0.002074617,0.08298657,0.05803641,0.018515123,0.03138782,-0.005026993,-0.040524803,0.004996158,0.0805144,0.044582378,-0.01681019,0.044069614,0.096079215,0.020308428,0.07835671,-0.026156116,-0.043997295,-0.029597588,-0.06150638,-0.112417616,0.004646029,0.00836815,-0.055726763,-0.014034195,0.0108561395,-0.014314973,-0.08799007,-0.0054475805,0.051893335,0.010835908,-0.050782274,-0.010229956,0.016770273,-0.014703168,-0.032873962,-0.06412814,0.06204894,0.01940911,-0.05857622,-0.081596226,0.0050325086,-0.022328524,0.03128132,0.03618165,0.078192964,-0.012458677,-0.046823706,0.10044353,-0.015999643,0.041681327,-0.024110457,-0.014426042,0.014327564,0.006023884,-0.08249452,0.030627595,0.010465646,-0.004768185,0.077719435,0.16339278,-0.091385044 +4.1.3.1,"The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate [3].",384,0.99999994,0.023894403,-0.11873862,-0.032930363,-0.035041586,-0.02588693,-0.035184406,-0.030566692,-0.04589411,-0.024238784,-0.08132412,0.14322068,-0.10675433,-0.07101874,-0.03160185,-0.028216997,-0.02003271,0.04560307,0.048741296,0.0076878686,0.003740346,-0.011096451,-0.030067015,0.025166992,0.075458884,0.03770094,0.021472523,0.021263262,0.007418564,0.02887158,-0.0807292,0.082448766,-0.06498941,-0.007153091,-0.03664668,-0.001553018,-0.0383766,0.0020486282,-0.089859776,0.038686026,0.067235425,0.061017305,-0.017819175,0.05204039,-0.02100628,-0.053411994,-0.005285476,-0.033513628,-0.011665105,0.008558407,-0.07790715,0.050248727,-0.044646125,-0.0713308,0.023487287,-0.046340734,-0.04623756,0.08619899,0.05701194,-0.03589339,-0.019572182,-0.015827985,0.041757256,0.034293946,-0.032707017,0.026097845,-0.034172766,0.05769294,-0.03426096,0.020954678,0.022626804,-0.09082902,-0.05559572,-0.009372181,-0.030637896,-0.009444278,-0.102546394,-0.053818982,-0.0036029553,0.08426645,-0.009986207,0.003963853,-0.08125807,-0.0012663667,0.021770172,-0.061911397,-0.033430833,-0.047396626,0.062485304,0.007669581,0.0026514523,-0.05188052,0.06101306,0.013294181,0.030144114,-0.06280564,0.055101525,0.023647526,0.0673031,0.026291894,-0.026360448,0.03938507,-0.014455353,-0.13413227,-0.04400918,-0.026336843,0.057216797,0.007486916,0.058948442,0.042678393,0.15390791,-0.07978438,0.0015226122,0.030955784,0.026270663,-0.05503553,0.04700527,-0.036291644,0.016751772,0.074040286,-0.044499006,0.07980528,-0.085257515,-0.039007574,-0.010680013,-0.10693677,-0.03478495,0.06792774,9.944315e-34,-0.0083637675,0.07529431,0.018303046,0.041808356,-0.051605865,0.024943763,-0.0341152,-0.028141322,-0.07049031,-0.034611925,-0.11523177,-0.035330925,0.021069886,0.056840017,-0.110521056,-0.10551725,-0.071497805,0.053772755,0.059062537,-0.048311688,-0.00089991716,0.09077235,-0.085312635,0.021110334,-0.028663447,-0.026521219,-0.044413205,0.018174546,-0.012391963,-0.013087259,0.04222304,0.021018399,-0.075275905,-0.03218711,0.035752475,0.012521786,0.028086305,-0.015106031,-0.0059950477,0.03618857,0.033003453,-0.025547087,0.020636057,-0.09569571,0.056700297,0.022445954,0.007392749,0.05613711,0.011237433,0.064198375,0.020825788,-0.00031677957,0.03933591,0.034501996,0.04045762,0.018449578,0.013434139,0.04436526,0.019376114,0.044231333,-0.025824886,0.087763846,0.07945724,-0.05120253,-0.023673292,0.030371655,-0.09510237,-0.019543087,0.004159857,0.012984232,-0.025748758,0.03420811,0.045892663,0.034286585,0.048376095,-0.041063372,-0.059799448,0.011091622,-0.009269089,-0.002972357,-0.092677034,0.06484381,0.00668856,-0.010584385,-0.09559457,0.025182892,0.014185819,0.06965386,-0.028423278,0.06050644,0.041653197,-0.016251542,-0.02458233,0.023307366,0.0045667486,-1.9435782e-33,0.05958853,-0.03392663,-0.016637256,-0.0563556,0.018016623,-0.017936602,0.042668648,0.064357616,0.03895459,0.021300899,0.094447285,-0.058402956,-0.057453677,-0.033992395,-0.0070773684,0.0154376505,-0.0015969899,0.017996058,-0.0048161685,0.012070928,0.008418085,-0.017828891,0.019846072,0.14072996,-0.055725187,-0.026512032,0.085337594,-0.0196837,0.07050905,0.09496217,-0.018484255,-0.018989295,0.027493682,-0.012291526,0.007128335,0.081451535,-0.0068925875,-0.0065538837,-0.08787169,-0.03642642,-0.059658512,0.061876386,0.008340336,0.01794411,0.049353577,0.05929525,-0.026827095,-0.03335986,-0.055967372,0.039783802,-0.03612631,-0.021910015,-0.016450407,0.06778507,0.06083263,0.077698156,-0.08723161,0.007508292,0.03781336,-0.0441327,-0.01330548,0.02375019,0.03034396,-0.033746734,0.06746282,0.018603347,-0.039663274,0.02756723,0.04048029,-0.01283127,0.17001641,0.06436601,0.03926653,0.015713194,0.0035614602,-0.16025016,-0.011490007,-0.061010577,-0.09349807,-0.04125925,0.07844871,-0.008804169,0.03957874,-0.05883575,-0.05819935,-0.09324209,0.009292708,0.0567653,0.01835806,-0.019144144,0.02935331,0.04718055,-0.020119807,0.024623401,0.03917875,-3.426308e-08,0.01728398,-0.039008748,0.010792395,-0.031653427,-0.03780022,0.13472795,0.028714215,0.010327903,-0.0077408995,-0.051792167,0.08374638,0.03177343,-0.010712246,0.026079759,0.07540129,0.008472758,-0.060468607,0.09280872,0.0054650255,-0.003208296,-0.024629042,0.045797538,-0.000529387,-0.05879269,-0.0056515173,0.085805066,0.058258384,0.0105009535,0.027751952,-0.022404423,0.007011639,-0.007591073,-0.00063790724,-0.009444808,-0.010374425,0.0987657,-0.09792521,0.06740412,-0.032877643,0.072885275,-0.053379506,-0.04461692,-0.05152282,-0.014544498,0.10796999,0.01537402,-0.043198947,0.023738734,-0.011846851,-0.065529875,0.022982309,-0.010051266,-0.04734069,-0.009088649,-0.012406805,-0.0435973,-0.102328956,0.051521033,-0.033596277,-0.040267315,0.04823434,0.032961268,0.09544333,0.033397205 +4.1.3.3,"This enzyme is involved in the degradation of N-acetylneuraminate. It is specific for the open form of the sugar. It also acts on N-glycoloylneuraminate and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.",384,1.0,-0.001993186,-0.04787223,-0.095031135,0.0030927698,0.030560791,0.0324271,-0.011564208,0.056660086,-0.004778252,-0.061505746,-0.012573565,0.09022641,-0.08352624,-0.017636707,-0.11951406,0.066103615,-0.030445786,-0.002874023,-0.03145112,-0.026280671,0.103538826,0.005081571,0.008475799,-0.0504828,0.08272433,0.005006681,0.027890662,-0.051527556,0.024395652,-0.076635055,0.017994318,-0.010679497,0.026389671,0.01696647,0.030982317,0.08534732,-0.038180012,-0.0147779565,0.03203566,0.02684613,0.013958057,-0.014605464,-0.09694481,-0.011239925,0.06538217,-0.044872858,-0.06865962,-0.011943642,-0.0021293343,0.054594744,-0.05425826,-0.07282619,0.012043617,-0.013420823,0.04970346,0.02490585,-0.08708842,-0.0012637023,0.004756462,0.054326817,0.08638228,0.036580212,-0.0047989334,-0.02453616,0.04989119,-0.08735166,0.111019455,-0.0751093,-0.010806456,-0.0052985093,-0.031440575,-0.043407846,-0.057888143,-0.018639287,0.014819625,-0.0067502814,-0.05865049,-0.0044800127,0.047589466,-0.01366238,0.07525324,0.03747272,0.060506288,0.055131704,0.013179306,0.008271145,0.025656855,-0.0031127224,0.07809275,0.016984079,-0.010366136,-0.03541166,-0.014657561,-0.010314019,-0.05784037,-0.019946016,0.03464022,-0.014454886,0.007590348,0.02138156,-0.022796221,0.07216933,0.023901993,-0.06532429,-0.07052042,0.091806605,0.028313786,0.062191907,0.06825808,0.044184156,-0.012361189,0.0013345756,0.02370163,-0.03333967,-0.049500674,0.11173421,-0.040552244,-0.0077667655,-0.050065003,0.025419213,-0.013460784,-0.034533303,0.0052087763,0.034378488,0.019318365,0.11479889,-0.038972907,3.6617942e-34,0.0893647,0.0036100629,-0.023479976,-0.038489845,0.060839653,-0.024997072,-0.08421722,0.016603652,0.005884965,-0.0063285735,0.02827455,-0.031416498,-0.022860942,0.022543548,0.02155039,0.05508912,0.03148828,-0.019823767,0.061452005,0.021470511,-0.018630648,0.013777793,-0.059474733,0.049577087,-0.037987385,0.05418546,0.009974318,0.059337452,0.005865404,-0.004964398,0.06579762,-0.061477654,-0.10656338,-0.016660834,0.07217959,-0.00709778,-0.0069785984,-0.025516754,0.0072902725,0.07013603,-0.010801569,0.049519204,0.03498522,-0.03025023,0.010014133,-0.04579213,-0.0077053183,0.07153919,0.03664672,0.023137702,0.02418235,-0.034596976,0.05938703,0.059701167,-0.024882749,0.06521384,-0.047442272,-0.03283313,0.020461058,-0.009021463,0.008024796,-0.06693271,-0.009912125,-0.016320115,-0.044461716,0.016383544,-0.080876596,0.007310311,0.017114526,-0.037020117,-0.08223538,-0.029436117,-0.001474136,0.05055596,-0.012084141,-0.072097376,0.008060738,0.044474456,0.060640793,-0.050843723,-0.0011449826,-0.017696317,-0.008435348,-0.07924001,-0.09233375,0.032411054,-0.00083961064,-0.14026125,-0.017927822,0.012262945,-0.031108718,-0.042469874,-0.09622956,0.01394007,0.015991077,-2.1847097e-33,0.081255406,-0.09479824,0.032369204,-0.025926119,-0.055701766,0.054609027,-0.026097909,-0.0010434838,-0.05367282,-0.050346177,0.03282715,-0.0032812078,0.060233116,-0.050007354,0.04838162,0.027143221,-0.040198304,0.09497275,-0.05348899,0.0073741544,-0.015424713,0.09580732,-0.012037565,-0.027769953,0.05024615,0.038288765,-0.06141898,0.00712537,0.087854184,0.07610555,0.03339186,-0.037495535,-0.03026433,-0.045935538,-0.048105016,0.09028571,0.026865155,0.0035822294,-0.04729473,0.01002881,0.03610264,0.030424463,0.05360565,0.032836452,0.055785507,0.088341035,-0.078973405,0.011151039,-0.0019673924,-0.04760092,0.088553496,0.019496372,-0.03681188,0.10027968,0.027787387,0.10487452,0.020985316,0.017113578,-0.09317189,-0.016234508,-0.027390558,-0.04079626,0.049278308,-0.018229866,0.06837123,0.044244308,-0.02961225,0.100237064,0.040540695,-0.026273835,-0.010119384,-0.005547709,0.04041798,0.088848226,-0.025558423,-0.046460874,-0.084566586,-0.063725665,-0.056748573,-0.062072363,-0.021647364,-1.4781949e-05,-0.033842567,-0.068989724,-0.062524915,-0.065262735,0.07024368,0.09948801,0.0050883833,0.023172172,-0.025552535,-0.042773232,-0.12697057,0.02346585,0.0110216485,-3.6457802e-08,0.04270576,-0.043701865,0.014293852,-0.10441821,0.00038067403,-0.049953233,0.021448366,0.044084225,0.045688726,-0.05128732,-0.07449176,0.15368776,-0.038302083,-0.011200201,-0.0021258579,-0.006631075,-0.0001680241,0.04696595,-0.051321186,0.010072253,-0.120507516,-0.0150694465,-0.03296862,0.03447429,-0.02392653,-0.08422194,0.07594738,0.05803585,-0.018585408,-0.012329874,-0.010616988,0.10145606,0.07104936,-0.06971875,-0.08022742,0.065836415,0.02319889,-0.07373123,-0.004570533,0.03275473,-0.030368384,-0.036253292,-0.06807795,-0.0018385556,0.011341486,-0.016795894,0.029688984,0.007926038,-0.033973962,0.04866371,-0.0035804044,-0.011224532,-0.08112253,-0.04719783,-0.09128045,-0.018692981,-0.020181933,-0.0022465312,0.07308596,-0.07361715,0.0034357188,-0.022330586,0.21110108,-0.08321119 +4.1.3.6,"The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10 (citrate CoA-transferase) and EC 4.1.3.34 (citryl-CoA lyase). EC 3.1.2.16, citrate lyase deacetylase, deacetylates and inactivates the enzyme.",384,1.0,-0.056038626,-0.07587992,-0.021649173,-0.021173704,0.08383988,0.010060991,-0.07399283,0.044665366,0.026595864,-0.04497395,0.056726225,-0.04474507,-0.064534895,0.046858978,-0.005889899,-0.021773145,-0.071812905,-0.03832535,-0.054989032,-0.09162502,0.04322198,0.0033144266,-0.0951423,0.023947503,0.08320377,-0.014812397,0.0595663,-0.044427626,-0.009456005,-0.10702436,-0.0031571575,-0.08036122,-0.007874745,-0.027649254,-0.019890605,0.05085821,-0.06074269,-0.13563293,-0.016054144,0.035262816,0.070429765,-0.04192152,-0.041690253,-0.08218063,-0.070318796,-0.05879467,-0.060660318,0.011879418,0.03131255,0.020487262,-0.061171226,-0.08570252,-0.010853368,0.053819317,-0.03186334,0.018641224,-0.027530858,0.023104716,-0.021673035,0.051815614,0.0022010976,0.0986602,0.003332386,0.026726691,0.00036584574,-0.06626249,0.12766556,-0.069215335,0.010641042,-0.018340493,-0.045531254,-0.09828667,-0.033507794,-0.0130954515,0.054310855,0.011065611,-0.007146375,-0.019897155,-0.032233838,0.037781633,-0.0027766954,0.011600046,0.029378535,-0.008982559,-0.057859443,0.0025078289,-0.083737,0.002200096,0.040462438,-0.047921035,0.06564402,0.06844596,-0.03822951,0.03882653,-0.011312204,0.061419383,0.006219447,0.05275885,0.009886419,-0.006210889,-0.031497966,0.10984301,-0.0893894,-0.045210946,-0.072924525,0.0069868173,0.035954315,0.02952723,-0.014707131,-0.0006385741,0.037293453,-0.034563206,0.06780464,0.0271205,0.015552761,0.08313486,0.014048309,-0.032627344,0.038513068,0.030315422,0.056727834,-0.03133441,0.1066173,0.058528394,-0.043424066,0.07596627,-0.05923088,1.0740644e-33,0.01731719,-0.007437367,0.008115868,0.0009469106,-0.024003122,-0.022352943,-0.097236514,0.11179599,-0.06313108,-0.083850324,-0.03297688,-0.019606235,-0.014952053,-0.0047041494,0.0064946585,-0.023278676,0.09140811,0.0026438066,0.047710296,0.0657393,0.08838293,0.067828104,-0.04508551,0.06889302,0.03256249,0.08787948,-0.02971653,0.04262258,0.021362318,0.014688238,-0.009434758,-0.057694525,-0.08743309,0.012332792,-0.0030041963,-0.030508604,-0.054037157,0.015455678,-0.020750483,0.063887164,0.069942236,0.041947618,0.022548454,-0.06639668,0.06216516,-0.05807128,-0.03855407,0.06445677,0.06080145,0.03456282,0.05324044,-0.017340593,0.089467645,-0.045729812,-0.047469683,0.051267937,0.009410683,0.011307753,0.0698237,0.0019210172,0.0041110734,0.10163509,-0.019802371,-0.01119322,0.013061281,0.05138496,-0.11453835,-0.05779756,-0.051095385,0.012038572,-0.13582739,0.0031536354,0.00812975,-0.009390153,0.09372406,-0.17072655,-0.104161754,0.025569614,0.017298825,0.056517363,-0.020606412,0.011094822,0.018037882,-0.021776566,-0.004511528,-0.06285499,-0.0057505686,0.024731757,0.01328842,0.025809387,0.031508848,-0.013155856,-0.017427472,0.025993325,0.08762985,-3.1886423e-33,0.07836725,-0.073045984,0.02109181,-0.037244428,-0.05687247,0.06745091,0.05332748,0.0367607,0.033890173,-0.015368608,0.10385129,0.009957925,-0.044971064,-0.0634845,0.0148971295,0.04764831,-0.045061477,0.046750337,-0.049933292,0.0036106622,0.012150455,0.011082127,0.07325395,-0.031423137,0.100137435,-0.047297508,0.012477522,0.043811854,0.039056074,-0.03238778,-0.017538417,-0.017835084,-0.021331526,-0.01577116,-0.13688745,-0.009902124,-0.08314914,-0.004073158,-0.0070848153,0.0016220489,0.020344183,0.058827415,0.015131274,0.09335705,-0.004724418,0.068265356,-0.035179246,-0.041092098,-0.004104164,-0.03605346,-0.00047738283,0.034962695,-0.060351048,0.021199958,0.005309079,0.06224188,0.08374455,0.047351476,-0.01658136,-0.052743565,-0.020159485,-0.03956001,-0.014769602,0.04169407,0.13617916,-0.008559677,-0.04561061,0.12498223,0.062360108,-0.02694013,0.07279553,-0.020763723,0.01388394,-0.069926865,-0.021790907,-0.028535917,-0.0943562,-0.04272445,-0.0036405956,-0.08184941,0.0034885968,-0.03576678,-0.003675916,-0.07226878,-0.0022053781,-0.05783491,0.007249133,0.05175687,-0.0036010663,0.022573851,-0.029540122,-0.015631085,0.018503318,0.05017252,0.060995422,-3.894223e-08,0.018954724,-0.057367533,-0.039385624,-0.011514302,0.04207728,0.0045260163,-0.069502,0.034288976,0.032365825,0.041622978,-0.06509972,0.03706892,-0.01059008,0.015453301,0.026317403,0.013932576,0.016758364,0.06511676,0.0327587,0.042609904,-0.021100525,-0.049072683,-0.065173395,0.053277206,-0.03719669,0.01131012,0.03396396,0.099659204,-0.021579433,-0.0031521018,-0.061875883,0.035129674,0.028295627,0.009732458,-0.032963395,-0.02786878,-0.03052483,0.0069283536,-0.073780686,0.029572902,0.04873027,-0.0060525592,-0.094522916,-0.01147366,0.026033266,-0.009902287,0.07606551,-0.00094500434,0.034659293,-0.020927941,0.033324704,-0.037093394,-0.04204988,-0.027070906,-0.03202489,-0.05319328,-0.006082909,-0.05103994,-0.02458925,-0.05354712,0.058837358,0.014212149,0.16758871,-0.042830914 +4.1.3.14,"A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans NCIMB 8944, is strictly specific for the L-erythro stereoisomer of 3-hydroxyaspartate. Different from EC 4.1.3.41, erythro-3-hydroxy-D-aspartate aldolase. Requires a divalent cation.",384,0.99999994,-0.078118704,-0.10289492,-0.1257649,-0.1189533,0.004511786,0.047107738,-0.06594243,0.024446882,0.008723922,0.011881455,0.021463819,-0.041896988,-0.09145354,0.06948799,-0.020898692,0.0150770815,-0.04880373,-0.02061594,0.02857153,-0.04846448,0.10555187,0.045780584,-0.043584425,0.021882085,0.091006726,0.014945008,0.057849184,0.0053674113,-0.04910681,-0.058325507,-0.023540763,-0.09032372,0.03851512,-0.06753175,0.12557891,0.08065493,-0.11128849,-0.071188636,0.059698332,-0.013944532,0.06060727,-0.03825508,-0.025599403,0.0329714,-0.06157883,0.028330076,0.026658896,0.08680544,0.07767914,-0.04700441,-0.03454644,-0.029648006,-0.07779001,0.0027437978,-0.00986145,-0.0028071355,0.024758788,0.029011484,-0.002974469,-0.019033697,0.022501249,0.012459944,0.038802974,0.015443796,0.038276374,-0.009367864,0.045217,-0.090697214,-0.01252069,0.002167578,-0.03827431,-0.077704236,0.061497383,0.02812195,0.004180805,0.044585884,-0.024581993,-0.01323886,-0.048796512,-0.035320282,0.066932194,0.02316148,-0.02202687,0.097252205,0.016222106,-0.020313395,-0.035249148,-0.041428648,0.018689815,-0.045145735,0.027674485,-0.05835581,-0.00829909,-0.019168228,-0.025484817,0.044383716,-0.0075045233,0.024443986,0.03149072,-0.0438068,-0.0019658082,0.028440379,-0.008201776,-0.08103063,-0.05288143,0.012666973,-0.01617925,0.091407634,0.054945998,0.023893746,-0.044779465,0.037119832,-0.001227629,0.012992794,-0.021757578,0.05145989,0.0842434,-0.053519804,-0.06188271,-0.01783172,0.036120173,-0.034573916,0.05599348,0.058485504,-0.012951209,0.0090917265,-0.12169432,4.2503885e-33,0.09790069,0.013530732,0.024996033,-0.013418577,0.0051374636,0.037752274,-0.067095414,-0.0014934667,-0.06651516,-0.049273577,-0.07959636,-0.06141703,0.06867419,0.06185878,-0.1305942,0.013418423,-0.076250724,0.07545342,0.01633929,0.02601472,0.027224492,0.1033777,-0.026996376,0.04019019,-0.036680184,0.04292176,-0.021564608,0.028031962,0.03668635,-0.016148467,0.024321156,-0.11585059,-0.118322246,-0.016752336,0.059917435,-0.06128118,-0.041671414,-0.026339693,-0.014683079,0.02424096,-0.013360556,0.07147815,-0.020756999,-0.01905719,0.04005223,-0.11722013,0.009228471,0.06926161,-0.016368981,0.047199562,0.035644736,-0.033001177,0.11199384,-0.044931762,-0.035566263,-0.05564886,-0.03689512,0.053595155,0.092530034,0.009326287,0.10991359,0.07149777,0.0027799509,-0.023078855,0.01482573,0.014981142,-0.02410413,-0.01877586,0.06874167,0.059892617,-0.054288,0.02751328,0.028275967,0.048281047,0.030079797,-0.07402692,-0.04725813,0.028654143,-0.00730766,-0.011265931,-0.027573802,-0.0052329954,0.024946399,0.018463114,-0.0745472,0.0027570284,0.018514596,-0.029076098,-0.041739035,0.029826093,0.03276027,-0.07805589,-0.0921444,0.0521294,0.008924964,-3.768298e-33,0.11219082,-0.094242096,0.07567815,-0.07004223,-0.035336062,0.022796484,0.08869198,0.0362684,0.029207788,0.03303681,0.13248791,0.020353885,0.015654886,-0.063132964,0.04044614,0.012014852,-0.03731849,0.025067054,-0.015747245,-0.0022688804,0.0018052139,0.053373277,0.018321643,-0.005683673,0.021923997,0.055253558,-0.01572325,0.054133147,-0.039644483,0.002766712,-0.013040386,0.031548377,-0.08697176,-0.0704688,-0.07325569,0.040556423,-0.116577506,0.02882925,0.0052381023,-0.02378451,0.043187797,0.1139282,0.028614495,0.04642227,0.04698379,0.01634537,-0.040351536,-0.016910242,0.003613675,0.012145651,0.015640501,-0.00037244929,0.01953984,-0.0023177983,0.050170675,0.0051399926,-0.008478057,0.069001175,-0.025015429,0.021753412,-0.06295216,-0.049460392,0.04710328,0.03641785,0.05257648,0.060080674,0.022887038,0.053268943,0.044228837,0.057790983,0.114141956,0.035238404,-0.017495662,0.046220962,-0.056329437,-0.051925354,-0.055543613,0.030064967,-0.0026450441,0.00026148674,0.020137172,-0.05878488,-0.013544983,-0.04336778,0.049956094,-0.030351039,0.039249092,0.07502906,-0.028226195,0.023098724,0.019353766,-0.0775709,-0.04717223,0.05606209,0.12414597,-4.572274e-08,0.07996959,-0.0046057315,-0.0008623173,-0.021714661,0.005311055,0.011286654,0.001661411,-0.0047764494,0.038196325,-0.009936712,0.062095758,-0.026344612,-0.0124369515,-0.016140295,0.07108998,0.018874282,-0.046831608,0.03726378,-0.009931393,0.042167615,-0.0072969203,-0.01879345,-0.1545816,0.024973499,0.074434325,-0.022972185,0.012456712,-0.017388143,-0.0068434086,-0.033870354,0.037338722,0.009208417,0.005272017,-0.047952265,-0.041513093,0.009491859,-0.10314623,0.023199564,-0.032060597,0.0075984052,-0.04209525,-0.028454643,-0.039692797,-0.02504547,0.008908801,0.06665742,-0.027515607,-0.00018995666,-0.07183231,0.011718445,0.06591172,-0.055939,-0.024208281,-0.08032814,-0.13621083,0.019961588,0.001543248,-0.038135484,-0.008400414,-0.059886727,0.04012643,0.0008437372,0.13330638,-0.021647718 +4.1.3.16,"The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase.",384,1.0,0.06063524,-0.06424333,0.021487761,-0.013619318,-0.03675622,0.010497837,-0.032930296,0.0017005875,-0.016278708,0.014459538,-0.013445191,-0.033170857,-0.02717926,0.08142078,-0.015325564,0.08310366,-0.090445645,-0.02758886,0.028177107,-0.031075602,0.08417572,-0.040762406,-0.041061953,0.010176193,0.037604623,-0.027169427,0.02801438,0.005768121,-0.085621506,-0.074637614,-0.05790279,-0.07346704,-0.04160108,-0.04067134,-0.01224263,0.026592234,-0.031456925,-0.00042079852,0.027200662,0.07846398,0.026268018,-0.05780224,-0.07200736,0.03068309,-0.028980188,-0.061651375,0.016623594,-0.017164284,0.059726026,0.0892809,-0.058778465,-0.025644545,-0.065520465,0.019462274,0.023765532,-0.03441008,-0.0306315,0.021538986,-0.0058429334,0.0144484425,0.031421658,0.01711275,-0.005627399,0.042122506,0.07461195,-0.040321186,0.033798594,-0.01296125,-0.10459545,-0.08332785,-0.015640259,-0.12634881,0.016533496,-0.03367926,-0.06484175,-0.07501316,-0.048315678,-0.040425677,0.015156123,0.018839713,0.05242202,0.05032244,-0.013937103,0.041295815,0.004592342,0.019596843,-0.04815013,-0.0124667315,-0.020118123,0.0029258318,-0.009968314,-0.05848714,-0.032201283,0.0025426252,0.080167055,0.00014936842,-0.0053382395,0.080058105,0.027275173,0.0007459425,0.026196465,0.022228152,-0.018887755,-0.07353497,0.025263201,0.03873529,-0.0020645245,0.10776542,0.022094043,0.023740146,-0.034653667,-0.034151338,0.0651572,0.083450355,0.04297674,0.1680233,0.017446367,-0.03472624,-0.0061190687,-0.06389413,0.009325298,0.036497254,0.13275535,0.04607001,0.016502945,0.020486282,-0.03673467,-4.161074e-34,0.13611609,-0.051566456,0.036135927,0.040183432,0.00217028,0.017905757,0.0090193655,0.08463089,-0.05335544,-0.008544347,-0.05371685,0.0068723536,0.041413914,0.058847796,-0.00035897904,-0.0043720915,-0.024610696,0.0074878023,0.0603363,-0.023465825,-0.03849892,0.041982178,-0.06771701,0.055024188,-0.060464367,0.036351074,-0.03561937,-0.0013642414,-0.016401554,-0.008228251,0.03342578,-0.031974643,-0.057479262,-0.0051600705,-0.019379247,-0.094254814,-0.028472751,0.027065856,0.009622946,0.0062115225,0.017767474,-0.018653227,0.016364034,-0.09844698,0.0560756,-0.033098344,-0.11907932,0.0831974,0.029960286,0.06830098,0.10027684,-0.029779568,0.05466314,-0.006148847,-0.027388833,0.024029542,-0.044540856,0.010423998,0.003798659,0.06516516,0.02537668,0.039744034,0.053270392,-0.0022209228,0.00019483964,-0.025880858,-0.044083998,-0.023556925,-0.100240275,0.06593678,-0.059735093,-0.024178162,0.045216497,-0.04067236,0.059232052,-0.07332295,-0.031889394,0.049737535,-0.06802409,-0.014557052,0.035955828,0.011428171,0.030970585,0.047619272,-0.035987154,0.008969228,0.09827967,-0.034974474,0.0396326,0.1148887,-0.019561753,-0.01560175,-0.15631345,0.01870534,0.095645994,-1.9432966e-33,0.09930756,-0.090149194,0.058720905,-0.061528184,-0.09951199,0.046497095,0.045726553,-0.007637661,0.026558222,0.06764685,0.09493204,0.07077522,0.028163895,-0.070676774,0.09528354,-0.08136777,-0.08271796,0.0030749643,-0.049461856,-0.04344281,0.018504413,0.028726226,-0.013484719,0.0060455417,0.124726556,-0.01678994,-0.00013845347,-0.0158704,0.047442835,0.03168625,-0.06975441,-0.014914783,-0.022907358,0.06641055,0.0060052555,0.015836993,-0.07250806,0.011689981,-0.05411147,0.0108006485,-0.053083733,0.033850204,0.025756326,0.052232094,0.009797692,-0.019944986,-0.017608806,-0.03450881,-0.036631417,-0.014614876,0.00937885,-0.01024102,-0.042349774,-0.025426919,0.022195615,0.058127657,-0.03446621,-0.01439302,0.069440365,-0.0568955,-0.05756137,0.019577898,0.04384406,-0.055192135,0.007288506,-0.026071722,-0.051413324,0.014178567,-0.006800241,0.045077782,0.11163008,-0.04621398,0.00468766,0.07378581,0.04696845,0.011970712,-0.058310445,-0.07150379,-0.0603394,-0.07202327,-0.029295355,0.04481841,0.055416077,-0.03252425,-0.013629119,-0.07908202,0.026129829,0.13320795,0.0037812286,0.0068120467,0.058033783,-0.009537368,-0.059381742,-0.0042872936,0.03282472,-3.603095e-08,-0.055768654,-0.0071128258,0.049961913,0.030433644,-0.09312148,0.032411363,0.07363621,0.06447606,0.035682812,-0.03781111,0.034206413,0.08171648,0.026939765,0.007990483,0.054788925,-0.053898063,-0.006104737,0.014723842,-0.011963046,-0.013220451,-0.058339603,-0.0758887,-0.07357562,0.013598701,-0.04030711,-0.053285107,0.0048980545,0.08629177,0.0143184075,0.016243313,0.02336565,-0.01020384,0.01910751,-0.06992852,-0.03788344,0.001192681,-0.03455172,-0.012018357,-0.053107418,-0.049300358,-0.024566839,-0.17645578,0.022925152,-0.017613746,0.04169659,-0.0016087288,-0.026693271,0.010798707,0.06351357,-0.0002850394,0.015818512,0.004438717,0.005583494,-0.062344182,-0.06994021,0.0061965715,-0.015211781,-0.05616,0.030503416,-0.064586766,0.014661039,0.10971033,0.15427878,-0.057362664 +4.1.3.17,"Requires a divalent metal ion [3]. This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), phthalate, syringate and 3,4,5-trihydroxybenzoate [1-3]. The enzyme from Pseudomonas straminea can also catalyse the activity of EC 4.1.3.16, 4-hydroxy-2-oxoglutarate aldolase, and the decarboxylation of oxaloacetate [3].",384,1.0,0.0145578105,-0.016420173,-0.054215714,-0.022775795,0.05348685,0.0010472382,-0.05905442,-0.006419956,-0.015216578,-0.02051832,0.001392298,-0.06644794,-0.079782985,0.038858347,-0.06867795,0.041255638,-0.049281463,0.011883405,0.0050444724,0.025840502,0.0625539,0.04180778,-0.037684884,0.031935666,0.01479663,0.088846155,0.0668213,-0.080380864,-0.046053845,-0.033347696,0.0009984281,-0.07344148,0.08597126,-0.070964,0.05255435,0.10701875,-0.04462342,-0.09430711,0.015505518,0.065450266,0.02204149,-0.0015891305,0.005339421,-0.058560416,0.024423053,-0.055369474,0.07657673,0.0053171744,0.089918,-0.053960465,-0.045405813,-0.02763727,0.022574231,0.077907704,-0.06416613,-0.027435154,-0.0015120107,0.034267493,-0.07018328,0.051074054,0.020166205,-0.010443216,-0.009885002,0.00062672666,-0.0068636336,0.0015229969,0.032126896,-0.054558147,0.016187798,-0.0009689703,-0.064413235,-0.06890123,0.042091493,-0.0449369,0.038191114,-0.0026937684,0.029589128,-0.10277587,0.054213613,-0.013646761,0.016034413,0.0017809053,0.056669686,0.03033184,0.031985603,0.024615888,-0.012617515,-0.04452901,0.04661411,0.02036188,0.0289799,0.025095573,-0.004393193,0.02634659,-0.015286686,0.08435456,0.013021299,0.0883514,0.05745794,-0.022012409,0.035223708,0.07323207,-0.06966215,-0.0695649,0.024318257,0.045846276,0.008068673,0.15555295,-0.03543048,0.03716765,-0.029211696,-0.04244708,0.030647349,-0.003942566,0.015475202,0.10337802,0.065109536,-0.060609996,-0.063340925,-0.027798994,0.031731855,-0.071822785,0.0691871,0.015337966,0.018282557,0.014221552,-0.109695904,1.826887e-33,0.0552781,0.039991613,0.0010156997,-0.04761963,-0.0051469016,0.02194865,-0.10388046,0.03882241,-0.069296956,-0.09049113,-0.009734162,-0.002788701,0.049188145,-0.038479436,-0.012344619,-0.058888473,-0.06772978,0.0175647,0.11270141,0.002297434,0.036209747,0.0031792552,-0.057761446,0.01913122,0.016119614,0.06639091,0.05174853,0.0013369989,-0.079364486,-0.005035733,-0.026632477,-0.0658082,-0.118751094,-0.0631952,0.0056811795,-0.022893362,-0.053042065,0.0034740854,-0.013669524,0.04338316,0.03404043,0.01938221,-0.027279664,-0.026701981,0.08981309,-0.0461969,-0.042423204,0.1810061,-0.002557171,0.061396454,0.036945317,-0.041586984,0.09612471,0.036130864,-0.086954854,-0.012807802,-0.036474396,-0.009600213,0.09359296,0.0078899255,0.025102999,0.048676215,-0.053459045,0.060871445,-0.025715342,-0.050479252,-0.011386439,0.017188089,-0.034821548,-0.0011640051,-0.0845386,-0.018087162,0.047207262,0.035316844,-0.013845428,-0.070721045,-0.061025087,0.035317637,0.06604302,0.026559902,-0.0058214464,-0.018012404,0.026395073,0.030443992,-0.050972063,0.02858248,0.028377524,0.022431199,-0.014523199,0.03566951,0.04583941,-0.1192951,-0.06839526,0.037416816,0.006897132,-2.498535e-33,0.11766935,-0.07725909,0.05951473,-0.034619547,-0.03903127,-0.029586112,-0.002745057,0.04047148,0.039117716,0.0069766925,0.07444884,-0.012854483,0.068621665,-0.04955491,0.07164285,0.017490042,-0.06699687,-0.023053829,-0.035423566,-0.0118128,0.07454762,0.065471105,-0.05808122,0.017281188,0.025426365,-0.008515928,0.013960419,0.007827718,0.060999256,0.056688353,-0.04634974,0.021161042,-0.026782326,-0.0080207605,-0.015380501,0.06915931,-0.073438555,0.033125263,0.07186048,0.020221153,0.05003063,0.010478518,-0.005214665,0.077533096,0.04589093,0.11226122,-0.089643344,0.049194425,0.012778332,-0.060559005,0.012906764,0.025512867,-0.04100132,0.018230112,0.038887348,0.044324778,-0.0029072529,-0.024871888,-0.043871995,0.020072108,-0.047298834,-0.053834062,0.085191704,-0.011658288,0.033234123,-0.035164043,-0.022544943,0.064787075,-0.00089938304,0.03283852,0.09719529,0.017640296,-0.026866904,0.014116327,-0.055674404,0.002430685,-0.084502116,0.020838683,-0.022892758,0.0198206,0.06985046,-0.008390438,0.11637916,-0.08613856,0.01580893,-0.0623696,0.08063295,0.13404512,-0.09592366,0.038808234,0.018325768,-0.07554093,-0.033016775,0.04133016,-0.023943117,-4.4661157e-08,-0.039146256,0.009561247,0.09001775,-0.06128478,-0.0023177168,0.046601262,0.03521212,0.044068836,0.054443885,-0.05963007,-0.0049310736,-0.0028488846,0.0058436473,0.04136131,0.007477264,-0.033669192,-0.103484705,-0.012556105,-0.032253794,-0.04155524,-0.049324043,-0.07465582,-0.09062768,-0.0064264084,-0.010677942,-0.0040699635,0.06387167,0.042479597,-0.030774476,-0.05107448,-0.04678414,0.049111836,0.051139496,-0.014327085,-0.08992058,-0.057825383,-0.013203894,-0.022753868,-0.08454924,-0.033855565,0.0016991304,-0.1118636,-0.08087693,-0.0051685297,0.024833316,0.025324333,-0.008274463,0.02708979,0.023934403,-0.053548936,0.0961755,-0.043588832,-0.020039776,-0.039713226,-0.056091152,0.014601809,-0.030425845,-0.01915907,-0.010921405,-0.049412973,0.018182091,-0.037544228,0.12225847,-0.032218695 +4.1.3.22,"The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.11 (citramalate CoA-transferase) and EC 4.1.3.25 (citramalyl-CoA lyase).",384,1.0,-0.04474108,-0.07229834,-0.0072460514,-0.03835222,0.084965184,0.010138014,-0.09830879,0.068298474,0.035609346,-0.06657376,0.06608455,-0.06758168,-0.05446801,0.048659723,-0.01700492,-0.033408586,-0.07170126,-0.0038219178,-0.05520085,-0.039652124,0.020635942,0.0039399303,-0.08097649,0.014027197,0.06896266,0.010737115,0.06373881,-0.055593055,0.0031256014,-0.1095173,0.019122077,-0.07392531,-0.011859974,-0.033917714,-0.029404148,0.0524362,-0.042375684,-0.11800254,0.0014971236,0.028812174,0.08190735,-0.04463912,-0.01418111,-0.08325014,-0.051053222,-0.07314356,-0.005587833,-0.003447049,0.036986005,0.013822473,-0.038039338,-0.11200837,-0.015592556,0.04894367,-0.038158637,0.022335304,-0.056275073,0.011751779,-0.005872053,0.06166032,0.0064902822,0.11168178,0.03614179,0.023395948,0.013738911,-0.08459638,0.12414715,-0.06903393,-0.0062637334,-0.030315284,-0.04577635,-0.07611102,-0.037110213,-0.023259157,0.03927111,0.023287253,-0.013611169,-0.025054831,-0.008915388,0.07001163,-0.020640368,0.0026914566,-0.004537871,-0.032641456,-0.023988685,0.0028554732,-0.0319763,0.0015107327,0.02145495,-0.04492779,0.05685727,0.0662436,-0.0017753248,0.02322382,-0.008008799,0.07336932,0.004198691,0.07783103,0.05606478,-0.00040845058,-0.03841193,0.10218153,-0.094818495,-0.04151338,-0.06421591,-0.022620177,0.030490678,0.007987679,-0.012186025,-0.010567872,0.028493922,-0.049813073,0.05174956,0.010623966,0.02365857,0.067076184,0.00066875375,-0.025235683,0.03322313,0.073226035,0.025269466,-0.04281945,0.07902033,0.07100837,-0.014021812,0.06518757,-0.06347339,-2.0872567e-34,0.039946847,0.01713281,0.0217206,-0.007905682,-0.025177866,-0.019555738,-0.11514207,0.10503238,-0.09218011,-0.077064864,-0.04981944,-0.009384611,0.0040134504,0.009009366,-0.014900509,-0.010967441,0.071045026,-0.012136993,0.04205964,0.016954541,0.070707224,0.058824897,-0.04579369,0.089733906,0.029001517,0.053758513,-0.028282031,0.03241526,0.05956163,0.009329749,-0.053555723,-0.07353124,-0.082085274,0.018117817,-0.017606162,-0.013437655,-0.054838777,0.0094072195,-0.045997944,0.030251931,0.06878602,0.04334967,0.004508927,-0.059410077,0.07300036,-0.04230857,-0.03990268,0.051704988,0.0826938,0.01950119,0.029470427,-0.01819843,0.11113999,-0.06767276,-0.05853193,0.052780103,0.009176066,0.0170402,0.06137981,0.016831726,-0.009828892,0.1300121,-0.03455705,-0.002313474,0.017156787,0.067984894,-0.08093567,-0.05449176,-0.021331776,-0.01610618,-0.14065552,-0.012179672,-0.005552102,-0.007987367,0.093738444,-0.15901981,-0.0988742,0.017122997,0.048575986,0.037229046,-0.046507597,0.0399079,0.027952418,-0.037348866,-0.025655238,-0.060312323,-0.01947639,0.04278529,0.026266227,0.034744322,0.03689772,-0.028836759,-0.006597345,0.0070698527,0.079670034,-2.3634583e-33,0.049815364,-0.074172184,0.0073535945,-0.02718395,-0.06485081,0.073095635,0.046827774,0.030026734,0.043769494,-0.0064116926,0.106338635,-0.017108707,-0.034592196,-0.050603032,0.012207043,0.050105527,-0.028265523,0.05915125,-0.027533254,-0.01012632,0.0051748664,0.019360535,0.0918057,-0.013685955,0.10504618,-0.035532072,0.034582634,0.045518257,0.036997218,-0.029787824,-0.038443547,-0.023457807,-0.035611905,-0.0028243277,-0.14674176,-0.015666075,-0.076424524,-0.008527518,0.020204945,0.010375897,0.0066623967,0.052694738,0.023173558,0.109003924,-0.0076749283,0.050392393,-0.022938311,-0.033001024,0.0019253019,-0.044378042,-0.019249855,0.028928436,-0.08481488,0.0019341611,0.016470607,0.060368676,0.08470928,0.044457663,-0.015567063,-0.064480916,-0.023886234,-0.05273944,-0.008491428,0.011464252,0.10776834,0.01153109,-0.048033983,0.083090946,0.044427402,-0.029865807,0.090436794,-0.002274175,0.025806187,-0.07486855,-0.008288572,-0.056082144,-0.06667827,-0.047348496,0.0047912397,-0.08911822,-0.0028912136,-0.026859704,0.008193874,-0.08326312,0.010480123,-0.0625725,0.0117000025,0.049971085,0.024507036,0.02632707,-0.038273692,0.026126886,0.036778305,0.05294921,0.044299807,-3.7134598e-08,0.034177255,-0.04430018,-0.033840198,-0.0026529955,0.059130907,0.010729458,-0.077042826,0.007288384,0.043253385,0.060419884,-0.067516126,0.038555767,-0.030524408,0.005400193,0.040839914,0.01651071,-0.011375597,0.06121303,0.020790463,0.041740105,-0.018710773,-0.035290595,-0.040831175,0.049827788,-0.035323095,-0.004045336,0.03158775,0.080208376,-0.04143481,-0.027105218,-0.05097656,0.048071705,-0.00018512874,0.0043696784,-0.071216814,-0.038739245,-0.021434058,0.012212765,-0.08086179,0.052728713,0.07338181,-0.041668415,-0.09633653,-0.0083706835,0.042693134,0.00030974086,0.0624859,0.008645536,0.026806245,-0.029059447,0.0413739,-0.031125763,-0.05093982,-0.025231494,-0.026633896,-0.06413391,-0.008395976,-0.0639311,-0.02173117,-0.058413364,0.04402069,-0.00043171018,0.18011485,-0.036052197 +4.1.3.24,"The enzymes from Rhodobacter species catalyse a step in the ethylmalonyl-CoA pathway for acetate assimilation [3,5]. The enzyme from halophilic bacteria participate in the methylaspartate cycle and catalyse the reaction in the direction of malyl-CoA formation [6]. The enzyme from the bacterium Chloroflexus aurantiacus, which participates in the 3-hydroxypropanoate cycle for carbon assimilation, also has the activity of EC 4.1.3.25, (3S)-citramalyl-CoA lyase [2,4]. ",384,0.99999994,-0.05617282,-0.080214724,-0.07977241,0.0068858913,0.08178859,0.08282951,-0.10212559,0.005158368,0.01638581,-0.038703777,0.004358517,-0.13891876,0.004199388,-0.048442613,0.0017074984,0.012711172,-0.059109636,-0.022380475,0.012594217,-0.044498537,0.050465543,-0.016391333,-0.11010939,-0.0044691,0.07083395,0.042392958,0.06553531,-0.11022207,-0.036308527,-0.05792589,0.040485065,-0.034982942,0.07424746,-0.020269988,0.06727035,0.082085006,-0.010468977,-0.11676042,0.115681194,0.033089153,-0.005240199,0.0004907789,0.008249322,-0.07243087,-0.07583812,-0.019636687,0.018531755,0.03642978,0.039001975,-0.09021674,-0.03880597,-0.028814517,-0.10693934,-0.0013008276,0.01069455,0.011795289,0.0021033015,-0.054178033,0.038996797,-0.010374552,0.056568913,0.008075565,0.02026252,0.04600898,-0.022617038,-0.10392852,0.06676217,-0.052977778,0.019562792,-0.037904758,-0.08593494,0.0030209175,-0.04010112,0.016089492,0.047772843,-0.010200914,0.045604456,-0.079183385,0.040848494,0.001445634,-0.05906429,0.054344855,-0.016246168,0.005248811,-0.0034717582,-0.061104357,0.0067606876,-0.04145714,0.0584354,0.06005536,0.021502843,-0.0039455877,-0.012583889,-0.061311934,-0.08315119,0.08406159,0.035238873,-0.0083502205,0.08531552,-0.0384321,-0.009922952,0.042809084,-0.030358806,-0.097158484,-0.06933986,-0.05202143,-0.019814555,0.09145311,0.0016784131,0.020577135,0.0070109903,-0.05017188,0.025440048,0.0022867739,0.0074730334,0.1208506,0.06389166,-0.0679218,-0.09802153,0.038520534,-0.01927712,-0.053801805,0.087447196,0.035931792,-0.009542443,0.07674173,-0.082159854,1.8854186e-33,0.06454128,0.0039528534,-0.037357047,-0.029896393,-0.0051104114,-0.009393776,-0.074916996,0.020726232,-0.04879415,-0.103190884,-0.021417696,0.008582894,0.017005254,-0.0043360167,-0.033636145,0.007246044,-0.043890946,0.000751977,0.028056633,0.05540636,0.00047768964,-0.046592094,-0.0026988601,0.042573296,0.014681358,0.018509436,0.023866061,0.005095365,0.026737234,0.017422138,-0.010455265,-0.041428782,-0.032326147,-0.014733649,0.079189055,0.0014437253,0.013692321,-0.010621804,-0.014950063,0.05938251,0.086281255,0.06998114,-0.044125866,-0.07769339,0.037269846,0.010831415,-0.047270086,0.042646937,0.06329408,0.059541788,-0.023042422,-0.036320742,0.15275155,-0.034559164,-0.014104013,0.027483802,-0.032646377,-0.022096608,0.030325277,-0.04694498,0.010669043,0.06972764,0.017663687,0.006002221,0.037107527,0.048714545,0.0032258262,-0.0057938662,0.06599789,0.02584709,-0.08620864,-0.027913159,0.027260471,0.048111532,0.04946805,-0.10488803,-0.05594008,-0.005947701,0.07929706,-0.01505396,0.009468699,0.06438281,0.03644509,-0.025328437,0.034816235,-0.044433944,-0.060566377,0.015895497,-0.014673383,0.017664978,0.108270474,-0.050247613,0.029757733,0.0045939647,-0.019793496,-3.20237e-33,0.14250138,-0.14893259,-0.0033249473,-0.08846692,-0.00920005,0.021363176,0.041416265,0.025843598,-0.00034453237,-0.0039357757,0.119667396,0.04126448,0.004167699,0.055732857,0.05012764,-0.059209026,0.06964763,0.076456845,-0.015967328,0.01525335,0.0052968888,-0.037402075,0.04056095,0.0062902085,0.05136772,-0.015585813,-0.053426508,0.030426115,0.01684475,0.016583597,-0.010495948,0.038433652,-0.027242966,-0.03051078,-0.09488056,0.068951435,-0.04760085,0.037942532,0.008700511,0.061487507,-0.011819399,0.0071735666,-0.008406739,-0.015542488,0.009690332,-0.00433016,-0.013932167,-0.00063249626,-0.04207094,-0.026421966,0.026728425,-0.0211043,-0.018794784,0.025271399,-0.026697053,0.060313933,0.036960885,0.06054237,0.026420703,-0.1133404,-0.1539974,-0.017368305,0.014405241,-0.036630176,0.037835274,0.11566018,0.0012930846,0.074927144,0.0365474,-0.04862977,0.07670055,-0.02450154,0.035575498,0.0018335669,-0.008860988,-0.0672031,-0.05560141,-0.03390521,-0.03977689,-0.0043661576,-0.016394915,0.0080205,-0.008397172,-0.048244353,-0.057929233,-0.09486178,0.0015505842,0.026832579,-0.031737097,0.057773978,-0.04549553,-0.026902469,-0.02078646,0.046963718,0.09958412,-4.1829107e-08,-0.06855731,-0.006195019,0.073340476,0.06503437,0.05873285,0.06470215,0.01827433,-0.069948316,0.04808503,-0.012252456,0.014807279,0.056174666,0.08720587,-0.017000334,0.028163387,0.020074304,-0.056199905,0.025181942,0.0030526044,0.016084163,-0.06291817,0.001442532,-0.040647652,0.06436145,0.04921404,-0.013598132,0.048976254,-0.0007439161,-0.0074220374,-0.04455808,-0.03662515,0.0595386,-0.008600777,0.036043134,-0.08969369,-0.07256826,-0.033283688,-0.014374949,-0.04461954,0.02417955,0.048351202,0.08494892,-0.12482641,-0.01884285,0.045808785,0.07276901,-0.042648356,0.022292892,-0.0082568,-0.05261102,0.0128730135,-0.035971347,-0.036183078,0.011563146,-0.03745193,0.0062410883,-0.036806542,-0.0934943,-0.0422264,0.01969831,-0.005670107,0.065325215,0.11012985,-0.017835913 +4.1.3.25,"Requires Mg2+ ions for activity [3]. The enzyme from the bacterium Clostridium tetanomorphum is a component of EC 4.1.3.22, citramalate lyase [2]. It also acts on (3S)-citramalyl thioacyl-carrier protein [2]. The enzyme from the bacterium Chloroflexus aurantiacus also has the activity of EC 4.1.3.24, malyl-CoA lyase [3]. It has no activity with (3R)-citramalyl-CoA (cf. EC 4.1.3.46, (R)-citramalyl-CoA lyase) [3].",384,0.99999994,-0.046217043,-0.06797301,-0.048874497,-0.034568373,0.106683016,-0.016224956,-0.022235757,0.012844519,0.06635174,-0.037257295,0.030816443,-0.108799785,0.026950486,0.07815319,0.022243267,-0.043812297,-0.018384973,0.0010161207,0.027497679,-0.017920103,0.072110504,0.05342524,-0.049158856,0.0063178767,-0.007860708,0.04870833,0.07159755,-0.08820574,-0.0058676396,-0.037077483,-0.038654476,-0.035638776,0.07287261,-0.09072179,0.04477017,0.083009794,-0.10150831,-0.062264457,0.056042653,-0.015484773,0.0073487973,-0.005163106,0.03134991,-0.027800359,-0.08448212,-0.051958747,0.046110652,-0.031012246,0.046024017,0.046582446,-0.04933146,-0.038257357,-0.01054111,0.06565586,-0.03987251,-0.02559354,-0.087437436,-0.0024322704,0.015190905,-0.022599475,0.042112052,0.061931133,0.061160628,0.02623486,-0.023160221,-0.091810286,0.03855547,-0.06412618,0.01088745,-0.08696786,-0.0012145742,-0.018792018,0.014276164,-0.013895668,0.015302234,0.0324625,0.07729195,-0.09556404,-0.0050761728,0.005571226,-0.023934228,0.008930807,0.04554148,0.06686606,0.03485092,-0.045482155,0.04175757,-0.01685792,0.021445874,0.037008896,0.15854084,0.085453495,-0.027439822,-0.025061462,-0.015384991,0.103107534,-0.090022415,0.011611623,0.0054168557,-0.017951777,-0.0524173,0.071038395,-0.053064387,-0.025194146,-0.07483004,-0.00957307,0.0037724054,0.058716692,0.015605186,-0.017667282,0.05826974,-0.043720234,0.034720857,0.020032257,0.034012,0.05884166,0.02562915,-0.08920194,0.0112703405,0.033132344,0.043969862,-0.02520748,0.021085558,0.028480731,-0.015463969,0.12035059,-0.049289264,1.8679922e-33,0.014542293,0.025654117,0.022235438,-0.015719408,-0.025728473,0.00018293355,-0.08599713,0.040052116,-0.07203407,-0.03394046,-0.07333764,-0.06103488,0.00791882,0.02350294,0.001447505,-0.012556831,0.0070621464,-0.015748937,0.11024009,0.036763657,0.02387007,0.095060125,0.02133191,0.04663839,0.04248017,0.10087311,0.034599755,-0.04161835,0.042529937,0.018199755,0.041376665,-0.079297386,-0.051944584,-0.014690947,0.086459175,0.062143303,-0.056427535,-0.0026585585,-0.07691664,0.030409764,-0.005167345,0.027918413,-0.07071371,-0.042762756,0.032865446,-0.051452648,-0.03857132,0.07535136,0.007314788,0.041896336,0.04652956,-0.026990142,0.03980363,-0.058297254,-0.080479555,0.06529171,-0.03319214,0.034317292,0.08111271,-0.0011590584,0.019564528,0.06513533,-0.022776922,0.0062239976,0.06138393,0.009901435,-0.05828473,-0.08771489,0.003097985,0.016297413,-0.09143469,-0.034905523,0.024637183,0.009216343,0.084166415,-0.068242386,-0.091603145,-0.02020428,0.06430938,0.03896228,-0.017519725,-0.037605513,0.087804236,-0.032420713,-0.0286635,-0.06161425,-0.089301,0.04533688,0.024714652,0.013311478,0.051874463,-0.06368585,-0.061064288,0.0640312,-0.047559664,-3.351804e-33,0.0766276,-0.108433925,0.08071356,-0.05494091,-0.08944562,0.07180308,-0.056688156,-0.022217048,-0.0067065354,-0.012776754,0.13885981,0.02990344,-0.074717246,-0.04304569,0.058977786,0.041397613,-0.013570619,0.05729235,-0.061025973,-0.007857927,0.00435071,0.043777093,0.04417516,0.001747821,0.06339125,0.044478092,0.054690883,0.042076435,0.08000403,0.0008291305,-0.036024578,0.037389815,-0.018420283,-0.017475042,-0.07405928,0.01651156,-0.05198782,-0.032358475,0.05636684,0.07321677,0.041737903,0.07355653,0.060817197,0.0075950194,-0.022456493,0.006193808,-0.025594648,0.0029711379,0.032771014,-0.07464232,0.007980014,-0.030104512,-0.044526495,-0.054333635,0.051782828,0.049633283,-0.040464364,0.0035887617,0.032247227,-0.10320787,-0.050583895,-0.06485018,0.014206522,-0.03142306,0.04618484,0.053676363,-0.029482761,0.057756085,0.04801521,-0.06125563,0.03778664,-0.018097494,0.042675514,-0.059323505,-0.028134366,-0.014217183,-0.052254297,-0.029253442,0.055929624,-0.050992593,0.024703039,0.0063970773,0.006850958,-0.10146439,0.027913228,-0.059382167,-0.005086532,0.08331468,0.04606838,-0.0060618427,-0.09387563,-0.013013579,0.036621787,0.05394103,0.081455775,-4.8487113e-08,-0.019007573,-0.04351116,0.017269142,-0.03352787,0.029617233,0.041257843,-0.012713268,-0.04005994,0.017323948,0.031007454,0.023435418,-0.0012138265,0.027203733,0.0072727976,0.012485739,0.061928134,-0.030969607,-0.008737964,0.0029390103,0.010087106,-0.07177116,-0.062925056,-0.12359355,0.0582682,0.008871178,-0.04139126,0.045296684,0.011916667,-0.032585002,-0.0038517856,-0.07647562,0.032777935,-0.036716226,0.007481145,-0.06523202,-0.013856894,-0.06949032,-0.07773761,-0.069347724,0.025020862,0.024834799,0.011787447,-0.06126757,-0.041810106,-0.0073553557,-0.034411844,0.006395358,0.056333978,-0.094282,-0.042892367,0.019496037,-0.075835064,-0.077746235,0.048392616,-0.012957202,-0.020187765,0.041561943,-0.106426515,-0.050065782,-0.09010953,0.028010244,-0.006067858,0.12173405,-0.03195359 +4.1.3.26,Also acts on the hydroxy derivative of farnesoyl-CoA.,384,1.0,-0.10541232,-0.025952434,-0.005517426,0.042601056,0.084024124,0.017342724,-0.10927459,0.080222726,0.06734516,-0.07307976,0.027074605,-0.023049787,-0.04913544,0.016415235,-0.0035901903,0.0021372342,-0.031907786,0.04989767,0.001141214,0.06387611,0.029334573,-0.032103736,0.036537614,0.024374487,0.020989526,0.058412448,0.086758405,0.012752721,0.050486896,-0.09150355,0.040682357,0.087501004,-0.015558833,-0.03345947,-0.06240912,0.07996368,0.025802797,-0.079744406,-0.0039717,0.051344443,0.04823152,-0.06741646,0.010868045,0.02229249,-0.012299377,-0.09613532,-0.005372197,0.026835248,-0.0011173189,0.07458194,-0.018583247,-0.047104795,-0.098977804,0.0069210464,-0.045051515,0.006389977,-0.061945107,0.024100235,0.028243965,0.05671529,0.0005483377,-0.0029580796,-0.030768732,0.024000984,0.0010503223,-0.02461488,0.0034081216,-0.060050655,0.042093795,-0.043005697,-0.06008054,-0.03491484,0.030124286,0.02259033,-0.0020892848,-0.012357589,0.0164054,0.023853509,0.06313125,-0.04689994,-0.08124757,-0.0017902055,-0.0074655204,0.043265216,0.04389686,0.05771496,-0.050861068,-0.03564758,-0.01793299,-0.0012442035,0.02525993,-0.033374738,-0.07107126,0.0077582775,-0.026446467,0.050675027,0.04790475,-0.010705109,-0.03407741,-0.028533133,-0.004918564,0.034846887,-0.09668726,-0.03472057,-0.03736178,-0.035268806,-0.021067344,0.03724966,-0.031085206,-0.035132635,-0.072796874,0.030034423,0.06735309,0.0074003534,-0.076003164,0.0052550607,0.025969824,-0.03011141,-0.031360008,-0.023764562,-0.049026143,-0.029145332,-0.019258296,0.076858476,-0.0050973226,-0.029190365,0.0044962955,-1.1389188e-33,0.047547393,0.018512413,0.0048466157,0.0068685617,-0.046734713,-0.048613522,-0.07539544,0.04784348,-0.043853637,-0.0034541301,0.007994485,0.03869699,-0.015695574,0.011326268,-0.012712825,-0.048270922,-0.03819696,-0.016798573,0.076783806,-0.03123214,0.020024076,0.032975,0.007110511,0.045172907,-0.072449654,0.015259735,0.027391111,0.0626187,0.062037386,0.033917803,0.012781073,-0.0799071,0.010819374,0.0062527866,-0.0071584475,0.06266133,-0.14790031,-0.027939474,0.009534852,0.13056453,0.018273367,-0.035064917,-0.07996894,0.023297362,0.014052062,-0.03904819,-0.0064317817,0.07774011,0.073145166,-0.06260396,0.040582422,-0.02453342,-0.025328105,0.0050610644,-0.053637203,0.027112486,-0.042515393,-0.0382062,-0.037729185,0.008753206,-0.005186346,0.04822,0.046664413,0.016816203,-0.015465959,0.0063910973,-0.04488506,-0.0035630374,-0.026520753,0.010378577,0.007916887,0.05067514,0.11435996,0.049594134,0.01425089,0.0072181206,-0.013768491,0.025467733,0.117660955,0.053531993,0.041217208,-0.03746397,0.026035776,0.02430413,-0.049318586,0.0041125347,0.016821835,-0.07892635,-0.010501995,0.078966685,0.04922606,-0.13945551,0.021209981,-0.05407399,-0.008949023,-3.0075041e-34,0.014814063,-0.09593462,-0.04480385,-0.04753051,-0.019252509,-0.028060095,0.035047486,-0.02949673,0.012724235,0.011251847,0.11654152,0.06323966,-0.056412186,-0.05940872,-0.0058371024,0.0421532,0.077510945,-0.033772383,-0.051435404,-0.027609276,-0.043635033,0.0152075775,0.042588808,0.07933307,0.013257947,0.022209462,-0.010831976,-0.060235295,-0.013974764,0.15403996,-0.0011741691,0.008593674,-0.04499393,-0.0008012227,-0.013167487,0.08174582,-0.046234176,0.07966832,-0.031018479,-0.07514201,-0.06122083,-0.06561337,0.061065882,-0.014115033,0.06434897,0.079082936,-0.016239565,-0.12243057,-0.057563536,0.010710462,0.015983298,0.05751697,-0.016416578,0.0321581,-0.03980987,0.06711244,-0.032808594,-0.08377879,0.03391219,-0.07545967,-0.04849826,-0.030050552,0.015030438,-0.080721825,0.037953213,0.04911521,-0.085537575,0.03609738,0.092403546,-0.023643564,0.13545991,0.025956808,0.071310975,0.067445464,-0.0458072,-0.04822543,0.06657623,-0.055294365,-0.09329102,-0.014855896,-0.043984868,0.008349721,-0.03913179,-0.06485844,-0.1112986,-0.09555442,0.019358926,0.08121306,0.035115153,0.034983054,-0.016514873,0.016539324,-0.031836968,0.014884559,0.15150936,-1.820313e-08,-0.059016492,-0.08033689,0.020464655,-3.07565e-05,0.028780553,0.0816182,0.012065408,0.0031584154,-0.009493036,-0.013316226,-0.034320507,0.12258315,0.09375692,-0.04019964,0.0680855,-0.023074038,-0.006823729,0.038842574,-0.019194376,-0.11260798,-0.0690916,0.032521203,0.025973639,-0.008066062,0.035654448,-0.031387266,0.01558495,-0.019495599,0.008309077,-0.006057571,0.06963643,0.0027867923,-0.017307967,0.04388494,-0.014751622,0.042431537,0.082078755,0.055066332,-0.048274208,0.107556105,-0.013319829,0.013125688,-0.027846316,0.07990391,0.029606892,0.009163659,-0.022502245,0.04458872,0.009717436,0.034532834,0.052167755,0.0040479717,-0.062291346,-0.029803265,-0.06360053,3.4160676e-05,-0.06773825,-0.06909752,-0.01686242,-0.060737617,-0.05541883,0.05417863,0.17031065,0.003788552 +4.1.3.27,"The enzyme, found in plants, fungi and bacteria is composed of two parts, a glutaminase subunit and a lyase subunit. The glutaminase produces ammonia that is channeled to the lyase subunit. In the absence of the glutaminase, the lyase can convert ammonia and chorismate into anthranilate. In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)]. 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+4.1.3.30,"The enzyme acts on threo-Ds-2-methylisocitrate, but not on threo-Ds-isocitrate, threo-DL-isocitrate or erythro-Ls-isocitrate.",384,1.0,-0.02024318,-0.121964104,-0.055854358,-0.04472164,0.028376542,-0.030535782,-0.07934963,0.014043076,-0.009314599,-0.023906928,0.051228497,-0.013160761,-0.118652254,0.035867315,0.06458457,0.05805263,0.02536077,0.007857167,-0.019906884,-0.010222334,0.090442,-0.03698921,0.016215265,-0.014764594,0.08138211,-0.009420812,0.014947846,0.03586697,0.03468313,-0.091809236,-0.05068967,-0.05933225,0.0127565265,-0.011164054,0.03786842,0.045693938,-0.048095163,-0.032994572,-0.04157763,-0.028806426,0.11350122,-0.0008491015,-0.06525685,-0.011310464,-0.10537612,-0.05416345,-0.018045066,0.03125965,-0.043867324,0.041703813,-0.03364105,-0.06814124,-0.033075474,0.03351124,-0.09858628,0.08404539,0.010635129,0.00854512,-0.040991414,-0.06658391,-0.036672,0.025075085,-0.017925752,0.015303049,0.08359461,-0.008257451,0.060949594,-0.02642099,-0.03714194,-0.062519975,-0.032666188,-0.07507506,-0.022522489,0.06953768,0.04438666,-0.07899318,-0.017151987,0.032519322,0.09895295,-0.08160632,0.009616658,-0.06595924,0.026867166,0.044922903,-0.019609878,0.048984934,-0.05037323,0.061220534,0.024245745,0.0016958476,0.050986275,-0.028445143,-0.0641803,-0.056144536,-0.012667439,0.03304937,0.043254532,0.03201416,-0.0004321797,-0.035597473,0.025647236,0.047375966,-0.15424344,-0.02259865,-0.004085948,0.052448492,-0.019422438,-0.011525572,0.00025254395,0.0029419826,0.005957675,0.031986237,0.15187702,0.04984797,-0.010664167,0.022671716,-0.025671536,-0.020549748,-0.011313652,-0.0670888,0.0064020185,-0.047276195,0.035595417,0.06554351,-0.029386576,-0.0018253849,-0.022422431,1.3042713e-33,0.023074804,0.0072104763,0.021383513,-0.101098016,0.027457815,-0.022246828,-0.045786384,0.085438766,-0.060989205,0.040220343,-0.12482155,-0.12881419,0.038437475,0.030768398,-0.017980285,0.02633994,0.06340279,0.040444482,0.029065358,-0.0292871,0.037030112,0.06486717,-0.049735744,0.042841744,-0.06502775,0.085240066,-0.024048217,0.1334961,0.022682063,-0.0054542823,-0.02472075,-0.106554076,-0.037000645,0.009069644,0.0906729,0.07204214,-0.055361383,0.028438777,-0.039351907,-0.0076425495,0.031111242,0.060565945,-0.065034986,-0.030470684,0.01874477,-0.08687014,0.014038427,0.008151078,0.030855894,0.06995631,0.023607204,-0.052620176,0.046794515,-0.053314064,0.01137242,0.014600161,0.03727871,0.05164077,0.04608633,0.04633125,0.003843841,0.0056859115,0.009767435,-0.050740395,-0.020981701,0.061995085,-0.073501274,-0.017479576,-0.0033710238,0.11575682,0.0053774547,0.06201838,0.037808824,0.0033570384,0.086730435,-0.07750032,-0.02192353,-0.009139804,0.04036429,-0.01095331,-0.011531123,-0.010380084,-0.008052055,-0.018480856,-0.06492899,-0.042152938,0.035886005,-0.018057875,-0.07061188,0.039568234,0.051121872,-0.029056592,-0.03303098,0.00040351762,0.060389798,-3.9801967e-33,0.035950556,-0.020287234,0.047150806,-0.072244465,-0.026645256,0.0685162,0.010398883,0.046646032,0.052849766,-0.025917564,0.12712483,-0.04735452,-0.08062862,-0.031426653,0.05939089,0.029667044,-0.043582715,0.04704743,-0.016887374,0.005374918,-0.07337278,0.056980155,0.012616856,0.110550016,0.025654018,-0.011362821,-0.0021974002,0.089730956,0.039290093,0.055367187,0.0008775932,0.0075086732,-0.07053602,-0.0575452,-0.022257678,0.07083342,-0.05437124,0.005382766,-0.051940884,0.024590306,0.018972239,0.06402472,0.009170705,0.07964361,0.01989677,0.072170496,-0.08758275,-0.04460749,-0.0428529,-0.05749128,0.040269148,0.009723225,-0.015953792,0.08069933,0.0304175,0.07722915,-0.025600027,0.008014223,-0.11964302,-0.066822074,-0.0686892,-0.053159665,-0.046069544,-0.01593978,0.052048475,0.027464624,-0.0005665745,0.06739917,0.063076936,-0.007786603,0.066162564,0.033777706,0.0051711737,0.0029895175,-0.0345814,-0.095823176,-0.08928636,-0.0056368588,-0.04232733,-0.06087963,-0.0023859194,0.06769123,-0.043920893,-0.051647853,-0.056628853,-0.056371488,-0.0010860515,0.075537175,-0.002812288,0.057179015,0.03204182,0.012151816,-0.017767359,0.080770545,0.102640845,-4.042616e-08,0.025727626,-0.03332308,0.009705087,-0.047836173,-0.024908025,0.051033124,-0.039776452,-0.024959043,0.017323561,0.009587976,-0.032968223,0.07788045,-0.048848353,-0.008697369,0.082518116,-0.04028161,-0.047812413,0.0680093,-0.00045272935,-0.010846143,-0.023016054,0.024942668,-0.08911201,-0.0037005302,0.021293947,0.0011845395,0.007464269,-0.01660207,0.013520809,0.013141805,0.053101525,0.025146516,-0.0020374656,-0.03293555,-0.06162459,0.008367891,-0.030442689,-0.024612464,-0.03894411,0.04266087,0.020476576,-0.008823796,-0.085592814,0.023739949,0.018272808,0.02557068,0.03823855,-0.013591269,0.006249146,-0.038328536,0.010573483,-0.017981565,-0.05955772,-0.108750105,-0.03999609,-0.011265925,-0.024328612,-0.04554018,-0.042409576,-0.06701768,0.13850951,-0.003067324,0.16196156,-0.049878243 +4.1.3.34,The enzyme is a component of EC 4.1.3.6 {[citrate (pro-3S)-lyase]}and EC 2.3.3.8 [ATP citrate synthase]. Also acts on (3S)-citryl thioacyl-carrier protein.,384,0.99999994,-0.060319442,-0.011933291,-0.07654474,-0.039490893,0.08665725,0.033156462,-0.02925992,0.050441563,0.07755339,-0.00411199,0.059302513,-0.11184838,-0.06303757,-0.0049162447,0.05253735,-0.022989787,-0.06721134,0.015496421,-0.022379069,-0.14778842,0.06354836,0.048870727,-0.019585166,0.0054544834,-0.010931681,-0.016019313,0.06397769,-0.031612784,-0.0093571665,-0.08734085,-0.08345073,-0.04314935,0.01907501,-0.035548586,0.015295043,0.07350253,-0.10481608,-0.1468869,0.018478265,0.000605096,0.09386523,-0.007931413,-0.031358708,0.00093162386,-0.07964612,-0.014803377,0.030768827,0.046250068,0.055566583,-0.0044709845,-0.025189992,-0.096505225,0.03488979,0.054745574,-0.05934126,0.029557886,-0.054338206,0.019425865,-0.019197607,0.01802219,0.047074277,0.052781638,0.034348857,0.031713665,-0.014104452,-0.023829732,0.04392323,0.00428517,0.00047541552,-0.039861463,-0.049830522,-0.06194099,0.019909142,0.059017926,0.034353275,0.047398627,0.016868075,-0.04697503,-0.0027614809,-0.006253344,0.005784954,0.023529643,0.027817464,-0.00080868695,0.030861206,-0.033608787,-0.025376113,-0.0072126766,-0.007932691,-0.01563794,0.088678814,-0.016630052,-0.05654554,0.016810853,-0.032483634,0.09956564,-0.030994246,0.0148330135,0.0039200606,-0.024807232,0.035147656,0.12583053,0.0001687107,-0.042952918,-0.041741084,0.049461193,0.0049665216,0.07773532,-0.045796357,0.017819408,-0.0028352481,-0.09093051,0.03488973,-0.012246052,-0.009087646,0.1051736,-0.021212665,-0.04789832,0.065900974,-0.01183893,0.039249923,-0.02960064,0.03449756,0.041923236,-0.08258559,0.038909364,-0.09297864,4.3268987e-34,0.01609396,0.021790003,0.01589765,0.026037294,-0.00024148266,-0.023977347,-0.08397044,0.023517955,-0.098149896,-0.051729303,-0.06414845,-0.074069135,0.028833194,-0.020448497,0.000914522,-0.055886734,-0.013247789,0.012566875,0.074841775,0.028962782,0.04226259,0.04652879,-0.05128221,-0.005036922,0.003621248,0.11821119,-0.014165821,0.0073681804,0.027712984,0.022899656,-0.017790088,-0.036226794,-0.020302672,-0.02529494,0.01409298,0.01288599,-0.0497505,-0.006573419,-0.04903062,0.08977072,0.023693766,0.00047238873,0.015541902,-0.07839889,0.025623914,-0.069490016,-0.057999257,0.055768285,0.06989016,0.02826136,0.045335356,-0.08545813,0.12355151,-0.04436073,-0.0248459,-0.0013738816,-0.040339064,0.018199457,0.022327054,0.00041984007,0.00845541,0.056755155,-0.052727323,0.020009646,0.013819435,0.07964624,-0.164847,-0.06821044,-0.031495366,0.07887471,-0.09537141,0.025076678,0.059366707,-0.00567145,0.08086341,-0.0759739,-0.12825833,0.023779193,-0.054592628,0.10165992,-0.011519517,-0.03442257,-0.018364813,0.018262101,-0.02729852,-0.07188648,-0.0040902565,0.024828782,0.04242927,0.008063502,0.07688663,-0.009903009,-0.052674036,0.10723162,-0.013068588,-2.2029139e-33,0.046040867,-0.05836647,0.09904532,-0.053763375,-0.05980522,0.059085935,0.005895644,-0.012033699,0.00070683524,0.024023807,0.10145768,-0.010389201,-0.04519385,-0.088904575,0.028803773,0.017701257,-0.08209169,-0.015534557,-0.011367529,0.028317854,0.022699675,-0.035839476,0.035868254,0.025070263,0.044159107,-0.0067754947,0.033987656,0.033415504,0.05515577,0.0053560752,-0.028076094,-0.024052504,-0.02645334,-0.00257899,-0.11140245,-0.012640459,-0.04632702,0.0027356758,0.030208584,-0.001599748,0.07741163,0.08629511,0.050644703,0.075155534,0.016690245,0.090447515,-0.00075165904,0.014426209,-0.007075557,-0.07474631,0.003945447,-0.014886147,-0.00774337,0.049769543,0.049217798,0.07772502,-0.016090395,0.018315868,0.0212382,-0.0349308,-0.07083994,-0.09249138,0.037636023,-0.015359785,0.1020333,-0.030808156,-0.09771018,0.11835343,0.043118592,0.050451644,0.06594294,0.0018005184,-0.054623388,-0.066523716,0.011907676,-0.046860207,-0.07453502,-0.014513334,0.010223422,-0.044363443,-0.005641561,-0.03825495,-0.04132377,-0.08788742,0.0148913255,-0.012208794,0.033023544,0.11158424,0.0015400384,0.029057413,-0.0643242,0.026013635,-0.043108195,0.07173581,0.025474325,-3.811926e-08,0.00480301,-0.024823742,-0.0057496186,-0.03520544,0.029690454,0.0766993,0.024087202,0.04696355,0.038500134,0.061674096,-0.043526184,0.026005749,0.05262391,-0.056825224,0.062154934,0.07592456,-0.02569283,0.07716019,0.050460216,0.0045211567,0.0012473606,-0.04621671,-0.074603386,0.016156448,0.025963485,-0.00038977846,0.06984624,0.061341435,-0.027707698,-0.007993253,-0.078641444,-0.0018994862,0.001073546,-0.026983187,-0.038372844,0.034266055,-0.06209013,-0.035590377,-0.087344356,0.0290219,0.014991926,0.001946378,-0.077639826,0.0066550556,0.0077700433,0.005533967,0.068201646,0.05837631,-0.036505282,-0.0678705,-0.04203089,-0.07739183,-0.0103907585,-0.018274909,-0.054208897,-0.025590265,-0.009419274,-0.0604728,-0.01691889,-0.04602008,0.04725435,-0.005742146,0.13694936,0.021715555 +4.1.3.36,"This enzyme is involved in the synthesis of 1,4-dihydroxy-2-naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria), phylloquinone (vitamin K1 in plants), and many plant pigments. +The coenzyme A group is subsequently removed from the product by EC 3.1.2.28, 1,4-dihydroxy-2-naphthoyl-CoA hydrolase.",384,0.99999994,-0.0563036,0.039300364,-0.09468399,-0.016508587,-0.0033632335,0.03722404,-0.04558521,-0.02996542,0.0022357232,0.023336384,0.015009985,-0.07278799,-0.034396928,0.0031664942,-0.071206585,0.025071586,-0.102036856,0.0011217501,-0.0022985819,-0.03288795,0.048962656,-0.004814703,-0.044958815,0.0059368988,0.06694318,-0.009251969,0.049736083,0.013419553,-0.008129356,-0.0047628027,0.0061101173,-0.049158424,0.10722091,-0.035174586,0.020413613,0.06342124,-0.007046595,-0.06454778,-0.020162186,0.10983954,0.031337712,-0.012320552,-0.029662617,-0.008909144,0.036051493,0.031950343,-0.013284839,0.031228306,0.048065994,-0.011568844,-0.08411071,-0.032079063,-0.07800225,0.06426118,0.061825614,0.005382949,-0.02930849,0.06816012,-0.017783275,0.0393173,0.0850069,-0.045578573,0.006543759,0.032000206,0.031830344,-0.065281205,-0.010601419,-0.03388435,0.07513695,-0.06997682,-0.0026321115,-0.108976625,-0.00464937,-0.045207202,-0.012427549,0.02059182,-0.08412304,-0.037127737,0.021488978,-0.047998432,0.04349799,-0.02038338,-0.07652808,0.11167045,-0.031618074,-0.012916681,-0.03206728,-0.022484869,0.05571236,0.050239787,0.016400224,-0.036382146,-0.017960677,-0.01666365,-0.13364533,0.09617104,0.058066793,0.036425002,0.0131847225,-0.024282036,-0.02526232,0.033848055,-0.011303952,-0.11423515,-0.090939365,0.004069984,-0.036990542,0.0906053,0.02561902,0.021981603,-0.031227134,0.043007188,-0.03251691,0.00019083102,0.029563576,0.055782985,0.09188407,-0.06226538,-0.039457954,0.0872267,-0.012141171,-0.0026688713,0.07160654,0.053246427,-0.011291713,0.0413528,-0.07567155,-1.6838261e-34,0.05615156,0.066255316,-0.016912002,0.004019488,-0.007757855,-0.055453304,-0.10167134,0.01472269,-0.07308954,-0.11793846,-0.023900764,-0.034975294,0.03443199,-0.002492358,-0.019430136,-0.0134088,0.008643458,-0.07782797,0.048615586,0.084633656,-0.0075648623,0.02920036,-0.05344043,0.0054596663,-0.026852742,0.029209951,-0.00597631,0.032375205,-0.017658615,0.0131727075,0.019332785,-0.050776377,-0.046158794,-0.017340729,0.003967294,-0.042071197,-0.113689706,-0.023252789,-0.032139935,0.09327521,-0.016578613,0.020890187,-0.031401057,-0.010819649,0.07492621,-0.013969841,-0.023606742,0.16246438,0.08416642,0.036345698,-0.0024555656,0.049019203,0.11200561,-0.016649917,-0.03211217,0.07131708,0.033258162,-0.03924949,0.031069905,-0.010654395,-0.018725375,0.0333519,-0.052104115,0.076345675,-0.052421693,-0.04253643,-0.07558595,0.026414953,-0.026661688,0.022678878,-0.06417798,-0.0019241911,0.03553972,-0.011743989,0.008320154,-0.027248926,-0.027697403,-0.009925503,0.014238295,0.0032799158,-0.008358993,3.6626647e-05,0.014364812,-0.0066461954,-0.054796305,-0.0059263837,0.0299212,-0.022675386,-0.0029616894,0.008231581,0.0373983,-0.051543653,-0.018756181,-0.036780983,0.078136675,-2.2950096e-33,0.11797333,-0.09991947,-0.0039435956,-0.09455195,0.007430518,0.07505607,0.008559845,-0.023055814,-0.006373052,0.030971123,0.09771766,-0.020970682,0.038189203,-0.023546841,-0.007742436,-0.021952728,0.020336367,0.12998024,-0.00978651,-0.061051022,0.028095637,0.04267035,0.0010340897,-0.024504056,-0.011962644,0.0014446958,-0.027135143,0.06697038,-0.00050888,0.13761948,0.0030002256,-0.05697826,-0.04982327,0.0065908055,0.039335765,0.060208302,-0.09458103,0.014815005,0.034434434,0.055060748,0.005543995,0.017607857,-0.02792486,-0.008228106,0.06426071,0.038341403,-0.03936041,0.027542803,-0.019794315,-0.07185112,0.02344055,0.032790206,-0.0963214,0.0023340748,0.006949041,0.05197024,0.019645091,0.036360588,0.06311534,-0.03198865,-0.060161375,-0.10035213,0.038040515,0.013208335,0.00071000896,0.08234397,-0.0062341844,0.06619485,0.049375247,0.019713804,0.056801945,-0.00113031,0.076232344,0.026548011,-0.071431115,-0.048871845,-0.08558924,-0.020816002,-0.08255242,-0.021325702,0.026871532,-0.037499174,0.008773989,0.013226184,-0.049742658,-0.12711073,0.0106997555,0.09388114,-0.061359756,0.031242969,-0.021995738,0.012108526,-0.14226182,0.07433741,0.061939787,-3.8760405e-08,-0.003931803,-0.055754177,0.044325586,-0.02960247,0.079941854,-0.013078504,-0.07978934,0.014685292,0.12234474,-0.016881315,0.029244503,0.068351015,0.037864298,0.04762816,0.03149591,0.018324193,0.010603357,-0.00044490318,-0.02626345,-0.014090948,-0.08903364,-0.02248064,-0.08918978,-0.023326317,-0.044435795,-0.06062377,-0.023319192,0.07155865,-0.0034099442,-0.06642037,0.018200308,0.03250515,0.029010465,-0.011169682,-0.084971145,0.052140743,-0.043907598,0.0075106076,0.0074101887,-0.0029190844,-0.007300142,-0.058893926,-0.012755571,0.076923795,0.05224014,-0.00902368,0.04676584,0.054441664,-0.053913433,0.02474898,0.020037558,0.0007691146,0.0013835487,-0.071730554,-0.064493336,-0.00422323,-0.0067504793,-0.070226714,-0.014002966,-0.08726633,-0.037871927,0.03388873,0.18514806,-0.057993595 +4.1.3.38,"A pyridoxal-phosphate protein. Forms part of the folate biosynthesis pathway. Acts on 4-amino-4-deoxychorismate, the product of EC 2.6.1.85, aminodeoxychorismate synthase, to form p-aminobenzoate.",384,0.9999999,0.007277692,-0.028536255,-0.082927026,-0.08243949,0.074863195,0.054027773,-0.00044860647,0.01736454,0.0625015,0.054750703,0.05696623,-0.0328736,-0.047505848,0.02704755,-0.018911423,0.047397662,-0.12538151,0.009827622,-0.020506801,-0.02435066,0.040787417,0.04956901,0.020531235,0.0041990476,-0.022891607,0.03301701,0.08000852,0.023595953,-0.0006629116,-0.034041613,-0.010923619,-0.025290336,0.042588852,-0.027429663,0.04825116,0.13016157,-0.0644112,-0.018537072,0.016419364,-0.008658216,0.025439734,-0.057244554,-0.02039119,-0.02922414,-0.037623778,-0.011731997,0.0992741,0.020593382,0.05789071,-0.022643214,-0.07562444,0.0030711482,-0.03899657,-0.035837945,-0.01998503,0.03483285,0.05784336,0.0034478912,-0.081603475,0.017411333,-0.001794237,-0.038221125,-0.012061984,0.0026099603,0.022097666,0.05487819,0.041304916,-0.087303884,-0.029300291,-0.05657683,-0.03938188,-0.07135024,0.081804916,-0.026266286,-0.033974726,0.0633956,-0.06290963,0.010020543,-0.041854564,-0.0050984127,0.04156814,-0.016612597,0.001584331,0.035283748,0.098980546,-0.007457103,0.018004168,-0.014766976,0.027855512,-0.021494456,-0.029493455,-0.0024030956,0.033212457,0.059312783,-0.035434537,0.057770547,0.056979313,0.026350591,0.053722564,-0.03425695,-0.013444096,0.05885193,-0.055355374,-0.03725967,-0.024289021,-0.024184562,-0.03651936,0.11165578,-0.089418024,-0.025896644,-0.06775571,0.001207803,-6.751712e-05,0.015492819,0.0005750414,0.04934194,0.014000509,-0.003820702,-0.021039318,0.07740869,0.006031413,0.05000079,0.045137122,0.09712467,-0.039784756,-0.043806724,-0.10172335,1.1578798e-33,0.09949728,0.1389482,0.040009376,0.054975413,0.016609984,0.023337146,-0.056391846,0.010207518,-0.03326472,-0.056136526,-0.042623937,-0.07224464,0.06604227,0.00020577741,-0.069319025,-0.07758476,-0.07562015,0.0079106,0.07599035,0.010205423,0.0115648545,0.078584686,-0.031144738,0.034747656,-0.019714879,0.07149119,-0.002810518,0.03810932,-0.0024495423,0.0027816372,-0.06494496,-0.075434506,-0.14619312,-0.085535094,0.050289523,-0.07343727,-0.06605307,-0.021304136,-0.000905504,0.051566925,-0.021457387,-0.036142163,-0.03936615,-0.030671265,0.041670628,-0.034406155,-0.02333185,0.087056905,0.01676502,0.030310322,0.04123934,-0.049975537,0.10644117,0.005005117,-0.097237475,-0.090326086,-0.069938846,-0.05820936,0.005316026,0.06801535,0.07057591,0.0032541978,-0.06657116,0.025072588,-0.027130492,-0.06625774,0.025671765,-0.054332126,0.017399548,0.045891568,0.024869861,0.001261745,0.11120003,0.046698533,0.045532357,-0.052223172,-0.08908747,-0.011320977,0.011050793,0.06084788,-0.005654114,-0.00075719383,-0.054616444,-0.0686637,-0.02514475,-0.005169026,-0.01046726,-0.058559027,-0.006935012,0.0021267508,0.020289125,-0.12568972,-0.057826556,0.017103689,0.034480605,-1.8446412e-33,0.057943955,-0.040865608,0.016155109,-0.04245917,-0.049324844,-0.022432584,0.068914734,0.005817269,0.06294029,0.073954485,0.05884087,-0.050254226,0.064771526,-0.07570413,-0.045169704,0.023995996,-0.025341673,-0.009825408,0.08025915,0.016899314,0.00325733,-0.0128992945,-0.035356395,0.028497798,0.05642154,0.07911247,0.0027329428,0.07805244,0.00844549,0.050176788,-0.04933067,0.041976426,-0.041456085,-0.02106012,-0.07418333,0.055825483,-0.1022835,0.020835284,0.023248341,0.010364438,-0.0136887785,0.05629466,0.06042099,0.016222732,0.037330065,0.042450156,0.0029651334,0.022565123,-0.0027015354,-0.086373754,0.040828146,0.06449125,-0.04997397,-0.002809025,0.016647916,0.016768754,-0.05065335,0.03266985,-0.015195492,0.015857056,0.014498766,-0.05856225,0.04652022,0.07365895,0.012899682,0.023515042,-0.010340243,0.050079174,0.07868647,0.11905022,0.08881395,-0.0129368715,0.070278704,0.10130751,-0.008543488,0.015416957,-0.055404916,0.020283334,-0.029903606,-0.0073195747,0.021331241,-0.06283299,0.014091889,-0.049077746,-0.050534345,-0.1260418,0.059844013,0.030937562,-0.0346616,-0.005535908,-0.0015888142,0.01837792,-0.019857617,0.09698732,0.09490117,-3.53886e-08,0.07997257,-0.05175136,0.023029542,-0.042625442,0.038084835,-0.026134055,0.046751983,-0.011183121,0.056777507,-0.052751746,-0.07309508,0.026416399,0.001850011,0.021006646,-0.0043184017,0.07849178,-0.01993772,0.056973822,0.0099140955,-0.050451163,-0.02233787,0.033971548,-0.13091135,-0.0010001007,0.027573422,-0.009769146,-0.020416126,-0.017381733,0.008467011,-0.03479665,0.047050852,-0.006736635,0.020747326,-0.076923974,-0.07501121,0.042996716,-0.05120286,-0.06102826,-0.04675989,-0.016164936,-0.015488298,-0.030775849,-0.049726687,-0.022451928,0.03658755,0.061110448,-0.037425373,0.010816569,-0.044471506,-0.01703938,0.063700005,0.02515564,-0.010210328,-0.0801834,-0.125018,0.06539875,-0.011941694,-0.03175609,0.014121573,-0.09282804,-0.09207093,0.0012568894,0.14138767,-0.062146004 +4.1.99.1,"A pyridoxal-phosphate protein, requiring K+. The enzyme cleaves a carbon-carbon bond, releasing indole and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogues of L-cysteine, L-serine and other 3-substituted amino acids.",384,1.0,-0.01387212,-0.04563813,-0.00921317,-0.045787245,0.04905396,0.0870207,0.050269064,-0.022380468,0.033777922,0.13629282,0.038649976,-0.02195127,-0.10079428,0.09637714,-0.030033626,0.07121416,-0.04613869,0.036160756,0.021286711,-0.026413666,0.05428646,0.0049572014,-0.0011410554,0.03803379,0.03093246,0.066101156,0.057173844,-0.0047279834,-0.036844287,-0.048442345,-0.11272018,-0.09167162,0.041879438,-0.11547439,0.07995538,0.052665275,-0.10890875,-0.012457755,0.007272661,-0.035077505,-0.014969187,-0.039194044,-0.054141104,-0.018275907,-0.03258939,0.0056417435,0.04874046,0.041791312,0.054838657,-0.0538442,-0.050254453,-0.018101547,-0.012125279,0.029201696,0.032802787,-0.016205456,-0.070063494,0.040214024,-0.03750675,0.013336292,0.02428776,0.040564153,-0.029416917,-0.042387772,0.05495717,-0.025281046,0.0056262175,-0.037595082,0.00946099,0.049634032,-0.0795998,-0.08774005,-0.0061879815,0.009896313,0.03766207,0.02992417,-0.025985,-0.0077257953,-0.040427256,-0.010978691,0.04813169,0.0019069596,0.0072750202,0.047344033,0.016697226,0.012739974,-0.011354797,0.019801315,0.07748334,-0.05496943,-0.0036600018,0.005499749,0.031694062,0.006152991,0.028729679,0.019065285,-0.0055468366,0.044060856,0.024670986,-0.020343801,0.043364402,0.08213542,-0.09338256,-0.11912576,-0.047055207,-0.0050877733,-0.005470058,0.029975526,0.050645992,0.008575721,-0.08976185,-0.0060037533,0.018327089,0.05595871,-0.035202906,0.081811436,0.095283836,-0.045322146,-0.04209251,-0.010336459,0.09251814,0.008871283,0.061108474,0.11905813,-0.10713504,0.05387141,-0.109409876,1.7524169e-33,0.057134263,0.01888592,0.0489191,0.038007587,-0.00038802586,-0.04010773,-0.084866844,0.0058079623,0.011734451,-0.057235688,-0.08947735,-0.045923762,0.086528994,-0.016263835,-0.021985285,-0.06981018,-0.08959396,0.037105434,0.09303577,0.041088816,-0.001844463,0.043785073,-0.0377192,0.07589069,-0.020394834,0.07511278,0.0031125513,0.029067859,0.03502755,-0.020514568,0.04242125,-0.06518328,-0.14575313,-0.0061131064,-0.050783582,-0.09510051,-0.056391045,-0.017352663,-0.016682243,0.07590282,-0.077437304,0.048057426,-0.007045566,0.00023149452,0.034770533,-0.062448032,0.00926734,0.09524482,0.022208136,-0.0035658483,0.0419185,-0.028737988,0.021453016,-0.032982465,-0.084573835,-0.0012801065,0.028662752,0.0043902043,0.039991193,0.052523647,-0.027536301,0.034010086,-0.022226617,0.0011459566,-0.08094302,-0.035556015,-0.072665,-0.08853967,-0.00087574724,0.06277664,-0.06666666,0.027409103,0.06798167,0.019739395,-0.008160825,-0.09691892,-0.10112382,-0.010946997,-0.04483615,0.03905266,0.015195308,-0.043164007,0.002700815,0.036698118,0.0029511251,-0.07695408,-0.04209134,-0.058664374,0.0050821854,0.04354327,-0.036209658,-0.048939116,-0.051468447,0.028924504,0.020128159,-3.4861287e-33,0.1080694,-0.08080341,-0.015725125,-0.024851318,-0.04427456,0.047582053,0.052737903,-0.01015313,0.0020142458,-0.045925815,0.032972295,-0.039139207,0.10433429,0.036129724,0.031373173,-0.03997576,-0.03584341,0.046344567,0.007471408,-0.009664142,0.04316425,0.022701133,-0.026237603,0.0071665337,0.061933037,0.081564665,-0.022113504,0.084003195,-0.014598837,0.05777231,-0.012790915,-0.03777093,-0.07743997,-0.049470786,0.015291449,0.10453726,-0.04217388,-0.044791188,-0.044548415,0.04941392,0.003767407,0.083300784,0.07117972,0.008175226,0.020827612,0.049751062,-0.060929757,0.044169087,0.016730286,-0.05872691,0.055372637,-0.00029301693,-0.037570216,-0.023736117,0.019845244,0.024818942,-0.01949925,0.02917278,0.03749829,0.055930484,-0.0499674,-0.07922198,0.05572908,-0.032424062,-0.005547574,0.0039237337,0.01584468,0.038059108,0.04694746,0.022709934,0.045386184,-0.03085694,0.044839635,0.03687883,-0.011604691,-0.022024361,-0.023574091,-0.0058006546,0.03837475,-0.0701592,0.009731884,-0.013713631,0.020942759,-0.047091015,0.0245346,-0.048353806,-0.001872277,0.0785745,-0.011926969,0.020574588,0.040733647,-0.054239973,-0.01531364,0.14351997,0.08942431,-4.4171117e-08,0.10121408,-0.1128401,0.0051206276,-0.028397486,-0.0058408696,-0.0038470007,0.030846741,0.03601984,0.059379034,-0.13147855,0.045562584,0.010726022,0.044614296,0.06431085,0.022553489,0.015664153,-0.008585302,0.08450061,-0.035484176,-0.036383435,-0.07252964,-0.001976619,-0.14150777,0.017822314,0.026677422,-0.041272555,0.025484027,0.010834326,-0.022464275,-0.026441928,0.0075873467,0.03593235,0.053456146,-0.018831428,-0.038603943,0.06262803,-0.10701491,0.018105369,-0.053667996,-0.03945455,-0.033557117,-0.01542854,-0.090733394,0.01031355,0.035958815,-0.0009909288,-0.0248896,0.0013144267,-0.03263969,-0.020992711,0.041969184,0.0022803391,0.019009033,-0.047429748,-0.07803435,0.03529806,-0.02260978,-0.068382084,0.021663727,-0.09107182,0.050057814,-0.009969584,0.1342134,-0.0072428714 +4.1.99.2,"A pyridoxal-phosphate protein. The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme also slowly catalyses similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.",384,1.0,-0.040157713,-0.044940937,-0.030433038,-0.0443231,0.08121696,0.036405783,0.027406441,-0.004306264,0.052655995,0.12192323,0.010877421,-0.0030661263,-0.09635246,0.08218683,-0.03450387,0.07941739,-0.069384985,-0.0013719667,0.011259071,-0.037560876,0.09269261,0.020372406,-0.022301417,0.046547152,0.0354732,0.0633291,0.07662137,0.016332168,-0.02408761,-0.08147086,-0.09378043,-0.08296542,0.021637816,-0.09172187,0.07152471,0.097417556,-0.090407126,-0.008629109,0.016418045,-0.028001368,0.05479489,-0.015997676,-0.055217996,-0.016835583,-0.052497495,-0.006173078,0.022998406,0.06710599,0.016888693,-0.026966566,-0.06378381,0.013108195,0.0009529389,-0.011869682,-0.011153787,0.012697496,-0.020179575,0.038168233,-0.050463367,-0.004655081,0.043514427,0.014561424,-0.018717306,-0.042570993,0.0480228,-0.028260434,0.03777374,-0.054479893,-0.0050039836,-0.0033044114,-0.073394135,-0.08576394,0.0021623012,0.0007285498,0.03746769,0.017785493,-0.019008767,-0.016529309,-0.011827877,0.016680503,0.040238615,0.008539026,0.04974968,0.0150771355,0.045184862,0.024537569,0.015260192,-0.008701249,0.084753014,-0.013732604,-0.051999725,0.019400006,0.03258008,0.014275878,0.0017804151,0.0035246047,0.03057947,0.054306176,0.030216452,-0.026145713,0.03115499,0.10965477,-0.104455456,-0.10149155,-0.055622634,0.014042724,0.01285971,0.0658443,0.039115764,0.0136512695,-0.06429283,0.009028443,0.04146093,0.06625158,-0.012041629,0.10241123,0.076325856,-0.01246412,-0.038762458,-0.0023699848,0.06363462,-0.0164593,0.05881859,0.11786736,-0.109369226,0.06026193,-0.122124024,1.7709924e-33,0.039930105,0.007943442,0.018562907,0.04440574,-0.018351108,-0.035319798,-0.10830359,0.052028198,-0.025804179,-0.04855921,-0.07509135,-0.029857645,0.082270786,0.0146650225,-0.03361925,-0.09804587,-0.027026208,0.062957115,0.085972376,0.028537069,0.023081008,0.07702722,-0.04543722,0.06252803,-0.012118082,0.07261999,-0.009497267,0.046926316,0.037753887,-0.03424224,0.047975775,-0.11424926,-0.11527885,-0.021079835,-0.0020840112,-0.08682764,-0.050761756,-0.0021319361,0.006002684,0.058090854,-0.06304432,-0.0062723416,-0.006559713,-0.038350224,0.003660365,-0.08919608,-0.00016038732,0.05642443,-0.0015835979,-0.0022799005,0.039594796,-0.0344322,0.05466952,-0.038918525,-0.105707526,-0.019840911,0.017419092,-0.02319543,0.048714958,0.074189655,0.013253137,0.035085898,-0.037402105,0.0012109401,-0.04000133,-0.033033468,-0.025410928,-0.06680521,-0.0019456986,0.07609669,-0.0608928,0.03731395,0.06165923,-0.006490245,0.005023751,-0.077204704,-0.11450298,0.007934811,-0.03316157,0.039599393,-0.005711522,-0.039010163,-0.017796287,0.021032572,-0.023388732,-0.047569353,-0.049122825,-0.05757899,-0.004921649,0.054741297,-0.03518386,-0.078578286,-0.040120784,0.006895284,0.05142217,-3.197446e-33,0.11153097,-0.06877369,0.0005869752,-0.048763487,-0.06159488,0.050566524,0.045428604,0.008552566,-0.010134643,-0.04801735,0.013942521,-0.023827594,0.066458054,0.008113616,0.010080131,-0.018522233,0.0054522064,0.0017411086,0.012716245,-0.01174628,0.046522204,0.03389778,-0.013607168,0.033060603,0.06583975,0.060400404,0.012519552,0.051853403,0.0065862103,0.060263515,-0.044842623,0.019587047,-0.037074845,-0.049938377,-0.056536276,0.100926004,-0.07745549,-0.069302455,-0.053242836,0.02048039,-0.014097909,0.06315321,0.045183074,0.03119213,0.0056110276,0.054503694,-0.07145205,0.011033319,6.264623e-05,0.013943094,0.05887348,0.06928517,-0.0010743504,-0.022034898,0.005601303,0.016947765,-0.021519529,0.008117239,0.011534201,0.07823912,-0.006098595,-0.06905869,0.0004098755,-0.0016419063,0.022869462,-0.0076492415,-0.026244799,0.04204423,0.03479394,0.042060737,0.074784994,0.00029531925,0.029049132,0.066263124,-0.027195323,-0.014244691,-0.018562393,-0.020245397,0.03992812,-0.08192293,-0.0043658223,-0.035243265,0.015827166,-0.08374302,-0.028192874,-0.05750128,0.023533499,0.050730933,-0.02536215,0.049173124,0.041141585,-0.08396823,-0.015267856,0.113710284,0.064184204,-4.8894062e-08,0.0804791,-0.11398482,0.04489933,-0.014403533,-0.03108224,0.019603167,0.054399706,0.009600146,0.07280073,-0.098640986,0.009262117,0.0004586453,0.028467443,0.0391896,0.042927105,0.0362218,-0.012179941,0.067081384,-0.015242257,-0.038066227,-0.0669161,-0.025163831,-0.19591475,0.0286799,0.035381995,-0.050454736,0.014148627,0.04211902,-0.0129183605,0.015917001,-0.0129021425,0.024950232,0.052466504,-0.052124247,-0.019902706,0.038114585,-0.10361928,-0.029286932,-0.07256777,-0.03882738,-0.016285576,0.025936874,-0.0962071,-0.0029600435,0.022407217,0.04568193,-0.025187174,0.0027278515,0.011097172,-0.002885016,0.061712153,-0.02231141,0.009636642,-0.059250806,-0.12250783,0.06355186,0.005946641,-0.08451988,0.020188805,-0.063042946,0.026148668,0.016715936,0.17579275,-0.062123165 +4.1.99.3,"A flavoprotein (FAD), containing a second chromophore group. The enzyme catalyses the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme.",384,1.0,-0.076674186,-0.077523,-0.11153537,0.03493917,0.13352697,-0.011764803,0.048375804,0.08405285,0.010634517,0.011089426,0.07442654,0.051777117,-0.05853094,-0.0009566224,-0.050354466,0.0800646,-0.07669751,-0.024011081,-0.057629883,-0.03005276,-0.050182078,0.020156218,0.025469108,-0.0674483,0.04534621,0.016407965,0.015659997,-0.05202966,-0.0012265005,-0.012683538,0.08419586,0.051701196,0.050118778,0.032058552,-0.0376328,0.07136909,0.027417634,-0.05380643,-0.030201135,0.0273077,0.023939915,-0.032878574,0.016171861,-0.0134915905,0.045167338,0.026307967,0.012704574,0.063757256,-0.036800936,0.010753107,0.046876334,-0.06833386,-0.07715043,0.011308217,-0.025778422,0.040659357,0.007350178,-0.060821667,0.013640034,-0.0015409952,-0.021987181,-0.04032306,0.0176995,0.008196581,0.12501042,-0.06510864,0.0073289634,-0.015689546,0.040614918,0.0272579,0.04533626,-0.007858587,-0.05639904,0.015629426,-0.0052833236,0.0077219973,-0.019973157,-0.0058246213,0.06850177,-0.008157108,0.03575365,-0.060393143,0.08968794,0.052078642,0.048942197,-0.015224241,0.034907382,0.015455496,-0.0392407,0.105307415,-0.06408848,0.055151027,0.020270307,-0.0004761211,-0.0722541,0.10185214,0.042187467,-0.10526351,-0.03875052,-0.009800371,-0.045706388,-0.03427505,-0.04153452,0.00042445588,-0.059567098,-0.10218422,-0.032142576,0.05643495,-0.07456882,-0.018312562,-0.013301027,0.008335774,0.03386615,-0.081209265,0.017186403,0.03773739,0.018092297,-0.04626105,0.01065561,-0.048751336,0.018741908,0.07295867,0.033389825,0.08585896,-0.007147243,-0.041087918,-0.055899233,1.5811832e-33,0.06604598,0.050655525,-0.05803508,-0.024920736,0.014810209,-0.0061532566,-0.041825503,0.003081977,-0.0060384613,-0.034711935,0.0069452715,-0.00038000636,0.043710254,-0.047973588,0.021402167,0.016492344,-0.042560592,0.036922675,0.028343225,-0.11824876,0.022795292,0.08033293,0.011295574,0.05250455,-0.005000425,0.029293641,-0.056832153,0.020228274,0.008201219,0.012908819,0.014033484,-0.01739192,-0.03630086,0.052484978,-0.011007615,0.04242699,-0.061524186,-0.08357194,-0.049144384,0.07261019,0.02382887,-0.020604674,0.014939652,-0.0056493846,0.07074756,-0.05089005,-0.11299906,0.038902175,-0.033720683,0.05174713,0.027593711,-0.031959362,0.09848282,0.015787395,-0.046920594,0.008913608,-0.061174057,0.009208753,-0.017495919,0.007903943,0.0060006846,0.034421068,-0.0036947494,0.08887447,-0.05042342,-0.030897405,-0.011082003,-0.08773402,0.01710771,0.116315305,0.02665353,-0.0067889323,0.06250257,-0.038149886,0.0363995,-0.019743077,-0.05029831,-0.011120422,-0.09570863,0.0730514,-0.052215938,-0.06596421,-0.07031337,-0.0717301,-0.03338325,0.022433784,-0.026682924,-0.04829315,-0.030509653,0.007462393,0.07638318,-0.042688295,0.0115496395,-0.028641792,0.06572786,-1.0928039e-33,0.04215995,-0.1033463,0.027434047,0.012749395,0.011701669,-0.008099327,0.002865181,-0.01134425,-0.0334005,-0.023863385,-0.0041675298,-0.05454393,-0.08239568,0.005207565,-0.0073997867,-0.013567397,-0.006853061,0.055712342,0.048435953,0.03519045,-0.057244707,0.049490612,0.04819433,0.10511707,0.046520736,-0.009794862,0.016612096,-0.010485774,0.030447664,0.035915457,-0.07184973,0.035378706,-0.069848284,0.04899844,-0.0056731757,0.045832124,0.058734935,0.039274305,-0.035020534,-0.0046612695,-0.0052692806,0.03570293,-0.026585953,0.04870538,0.024113279,0.06140345,-0.03199837,0.068971284,0.06464672,-0.057727877,0.019409884,-0.004073585,0.008590277,0.071286894,0.015269931,0.0062803165,0.051790316,0.058102753,0.027162228,0.009668687,0.024924157,-0.13864648,0.029855441,6.108867e-05,0.08520438,0.053347703,0.015979933,0.16718318,-0.028441612,-0.011947346,0.12838317,0.02395858,0.01191687,0.025840828,0.00029245517,-0.0035650595,-0.03160775,0.057259448,-0.030552851,-0.011721581,-0.0025366538,-0.006147663,-0.027143033,0.04474607,-0.046623636,-0.10825176,0.0032366728,0.07366702,-0.007372999,-0.029865464,-0.039613504,0.03653452,-0.010757077,-0.005227306,0.039630402,-2.9064607e-08,-0.016535545,-0.052151114,-0.024593614,-0.04680634,0.124494664,0.045369606,-0.034349855,0.009410854,0.011285158,-0.059651464,-0.117842555,0.13449316,0.045837402,-0.009037256,0.07710689,-0.0071968655,-0.066628054,-0.013934022,-0.01966123,-0.02419379,-0.07586334,0.033942237,-0.082570374,0.05156367,-0.12020979,0.04130551,0.08887819,0.0061565824,0.075407654,-0.029521147,0.043147612,0.018935733,0.041014004,-0.04997316,-0.13184476,0.026056288,0.06924,-0.104338676,-0.021588232,0.009896338,-0.08100858,0.050175205,-0.022241002,-0.03423884,-0.07304683,-0.007531376,0.02781942,-0.01373035,-0.056817956,0.0049274573,0.021441828,-0.030854631,-0.003662639,-0.03393839,-0.11399948,-0.033738453,0.018396623,-0.079250224,-0.00077608984,-0.022702046,0.04643463,0.018149244,0.17106031,0.0073958402 +4.1.99.5,"Contains a diiron center. Involved in the biosynthesis of alkanes. The enzyme from the cyanobacterium Nostoc punctiforme PCC 73102 is only active in vitro in the presence of ferredoxin, ferredoxin reductase and NADPH, and produces mostly C15 and C17 alkanes [2,3]. The enzyme from pea (Pisum sativum) produces alkanes of chain length C18 to C32 and is inhibited by metal-chelating agents [1]. The substrate for this enzyme is formed by EC 1.2.1.80, acyl-[acyl-carrier protein] reductase.",384,0.9999999,-0.084858686,-0.002630012,-0.12524587,0.018029317,0.051242635,0.081167825,-0.09159083,0.019102542,-0.0030247234,-0.029921615,0.0030826568,-0.09806433,-0.06535746,-0.03727048,-0.080490574,0.007839237,-0.036614764,-0.015942153,-0.0039212797,-0.043999117,-2.306151e-06,0.06462513,-0.00063290034,0.032450803,-0.023439756,-0.066143654,0.019523803,-0.029663868,-0.057014596,-0.0518842,-0.0659345,-0.044482544,0.04243956,-0.0057256743,0.06191286,0.048993584,-0.04497002,-0.051313493,0.033067916,0.0134216435,0.081678405,-0.011289854,-0.02072765,-0.00180227,0.00035089106,-0.019109022,-0.017933153,0.013393679,0.040868107,-0.020734461,-0.043333054,0.013539041,-0.05368273,0.06132295,0.034932017,-0.027844056,-0.046873257,-0.055858277,0.025473872,-0.031725716,0.037617497,-0.029320918,-0.035798576,-0.010977048,-0.028052239,-0.08566527,0.043510903,-0.054396532,0.03021942,-0.05228616,-0.03398926,-0.05128934,-0.00980611,-0.016597118,-0.044258296,0.10320095,0.016844882,-0.07632066,-0.030183451,0.03208345,0.026821285,0.03231785,0.04722548,0.064308144,0.04346508,-0.042509787,-0.028629908,0.02481031,-0.02413469,0.013933459,0.0753515,0.06902388,0.020208623,-0.05683532,-0.039321262,0.037264783,0.065418705,0.04073627,0.009155292,-0.021063877,0.02088599,0.054745864,0.0028641066,-0.13615891,-0.03173353,0.042135444,-0.019064885,0.06264546,0.037095524,0.053276084,-0.018038722,-0.00053002214,-0.05820236,-0.04715784,-0.018027497,0.07404454,-0.009357416,-0.07862025,-0.07480607,0.02855664,0.009034874,-0.07842221,0.05137071,0.07246707,-0.033970717,-0.06339138,-0.12353617,3.9390533e-33,0.040725015,-0.028400924,5.8236616e-05,-0.018816082,0.07149369,0.0024230299,-0.052863233,-0.011882888,0.029013036,-0.08844214,-0.08542684,0.007894747,0.016695349,-0.10818186,-0.062890194,-0.029899947,-0.012896111,-0.06030626,0.015361246,0.028984131,0.028313333,0.021332815,-0.036000133,0.017024735,0.016392909,0.01115015,-0.08102783,-0.019691626,-0.01998568,-0.0121923685,-0.03895544,-0.081988595,-0.060815852,0.023738172,0.08054539,-0.058469314,-0.011093134,-0.057816904,-0.030791039,0.08769979,-0.025017066,-0.015569786,0.036532927,-0.03564186,0.05282723,0.0074952035,-0.1117687,0.101990804,0.008715229,0.13503812,0.04288891,-0.034336213,0.055121038,-0.024428457,-0.04815868,-0.027699295,-0.040515725,-0.024298023,0.064797014,0.07411395,0.003137674,0.04058024,-0.01616524,0.059136126,-0.043225996,-0.012755729,-0.08002671,0.046853364,-0.026361218,0.08106525,-0.036029514,-0.018529044,0.086995825,0.0020541188,0.088654004,-0.052918963,-0.06644555,0.018659316,0.03814134,0.030828008,0.061387554,-0.044821635,-0.045900512,-0.03549708,-0.028247409,-0.017042808,-0.026975129,0.0012962965,0.027486369,0.06495978,0.067719,-0.026821936,-0.026118321,0.037539218,0.012170586,-5.8523658e-33,0.11948731,-0.07098472,0.017227232,-0.102141194,-0.036960084,0.04912892,0.037600722,-0.0252803,0.005246328,-0.029290719,0.10882907,-0.012871778,0.063035816,0.010866104,-0.018631382,0.033610296,-0.0023386572,0.110390715,-0.0023366376,0.031506795,-0.058721505,-0.024911378,-0.010141945,0.007701174,0.06300931,-0.022786608,-0.05795655,0.058126286,0.06886829,0.05480051,-0.061506007,0.02452932,-0.06264997,0.0009901461,-0.057950653,0.015556371,-0.035375796,0.023950614,0.075472526,0.040173285,0.044369284,-0.027384039,-0.065055214,0.07883567,0.045582686,0.036206096,-0.039759643,0.029632472,0.01643388,-0.093416855,0.10388844,0.033445995,0.0364808,0.016725382,0.025470534,0.12500107,0.060167775,0.03017306,0.048974205,0.04000706,0.011062664,-0.09031569,0.027579684,0.0059930077,0.040662136,0.044689644,-0.0052447547,0.111966304,0.020686189,0.029981814,0.066031195,0.046658028,0.023061387,0.019533059,-0.06595494,-0.03198956,0.038785208,-0.037415415,-0.030829692,-0.010149106,0.043375794,0.0059808525,0.038995534,-0.056050804,-0.05734094,-0.035477035,0.10523648,0.057350516,-0.042827863,0.021996442,-0.008802137,0.031515557,-0.042079523,0.11270596,0.050686996,-4.6077524e-08,-0.024082774,-0.06803235,0.05807029,-0.06199697,0.05597368,0.06058806,0.08155723,-0.052225474,0.01071411,-0.04551636,-0.00617138,0.06336097,0.016869001,-0.011333988,0.08368728,0.033164766,-0.047853086,0.03374357,0.0484198,0.055684976,-0.040363904,-0.019057343,-0.100043364,0.010606676,-0.10024907,-0.043837883,0.042079065,0.05447624,-0.0071047163,-0.035016973,-0.03448179,-0.00037121333,-0.025870048,-0.035372555,-0.06548554,-0.03773073,-0.030475812,-0.08385367,-0.025041586,-0.04908745,-0.087817855,0.030699214,-0.06695631,-0.0030709668,0.03598523,-0.041836925,0.013789321,0.022439849,0.028584586,0.021577094,0.06236917,0.00089129235,0.039123062,-0.10201882,-0.032877427,0.005394704,0.019068314,-0.029789867,-0.11475268,-0.04551515,0.0003818543,0.012723535,0.18393707,0.00577482 +4.1.99.11,"A glycyl radical enzyme that is inhibited by benzyl alcohol, benzaldehyde, phenylhydrazine and is inactivated by oxygen.",384,1.0,-0.01629788,0.0030743098,-0.11616663,0.08219632,0.041699186,0.0223831,-0.0878453,-0.0041145543,0.025464281,-0.061336055,0.0640248,0.10339085,-0.046353262,0.07532381,-0.06543961,0.08513425,-0.06691462,-0.01898053,-0.10057647,-0.036292132,-0.007905846,0.04820447,0.045423307,0.010447996,0.08034871,-0.06860358,0.053451315,0.03954895,0.016691832,-0.028731076,0.10402501,-0.0029502455,0.016742699,0.019102694,0.025412079,-0.008250808,-0.046867464,-0.015032707,0.04335772,0.03351107,-0.010291128,-0.07138812,-0.12571786,-0.02128312,-0.03643285,0.02761235,0.0056644427,0.021673644,-0.034075364,0.021474948,-0.03481692,-0.052215647,-0.08105715,0.02998854,0.055413667,0.0003777722,-0.032905966,0.025470601,0.033671357,0.04626285,0.050904155,0.02877918,-0.038505945,0.03220307,-0.09356521,-0.037936192,0.06238936,-0.016558375,0.038810007,-0.038643997,-0.04255853,-0.13910401,0.005864014,-0.032400664,-0.05490693,-0.08229595,-0.011922956,-0.012580893,0.04704128,-0.016679743,0.0573805,-0.09256383,0.022861738,0.112048425,0.043036163,0.015043367,-0.004981474,0.026281945,0.015969612,-0.010776835,-0.032205872,-0.05927544,-0.017089095,-0.030011857,0.0021925855,-0.019104322,0.08284801,-0.06431489,-0.09846359,0.027349107,-0.005305135,0.05403178,0.033261236,-0.105113104,-0.112389736,0.0047768606,0.04393542,0.050563335,0.019320877,-0.04360637,-0.007173453,0.02866988,0.020164214,-0.06693872,-0.007409364,0.052106764,0.08379199,-0.027625792,-0.04266845,-0.010314994,0.046621967,0.039885245,0.09218434,0.0076823435,-0.061010804,0.059325453,-0.06873799,1.44059735e-33,0.08040415,0.03365453,-0.034364294,-0.020908428,-0.01948916,-0.058105852,-0.06053945,0.025566421,0.0032974277,-0.060109906,0.004564816,-0.049686458,0.030312156,0.044386514,0.015261687,0.0060410886,-0.015079431,-0.018006017,0.0034353202,-0.021288961,0.025886955,-0.009530316,-0.06289916,0.025557116,0.052975412,0.056869842,-0.028419469,0.033113245,0.037878733,0.0030664818,-0.0094404,-0.050071143,-0.122863024,0.03442702,-0.0060302992,0.042207398,-0.11254202,-0.08049474,0.0327865,0.013465779,-0.036360126,0.0037642347,0.014031577,-0.048068296,0.045609187,0.033304203,-0.0980759,0.072760575,0.011387444,0.054941643,0.06363893,-0.026626017,0.067950286,0.01889119,-0.06534796,0.05770228,0.024937898,0.00081989326,0.0060399235,0.00069961173,0.020000517,0.041521538,-0.07435206,0.052818626,0.005895703,0.043541986,-0.1347939,-0.040727694,-0.07398578,0.00066466216,-0.038881585,0.0425837,0.117769405,0.021905033,-0.04486607,-0.061683446,0.006840551,0.02096272,0.017106438,0.013327266,-0.004979408,-0.088509716,-0.017711539,-0.08543761,-0.029348101,0.007832208,-0.07249161,-0.04041902,-0.05632372,-0.025456777,-0.00041250448,-0.048309885,0.0043494436,-0.022121996,-0.001481815,-3.960287e-33,0.11791858,-0.04421566,0.0296479,-0.01227268,0.05457618,0.0612846,-0.029098965,-0.038014192,-0.05212735,-0.09619599,0.020911211,-0.041408468,0.028077802,0.008186256,0.087058336,0.021483125,0.011109194,0.027291385,-0.0040164366,0.004328812,0.006068651,0.04867029,0.01460961,-0.0071080984,0.034231313,-0.00017038644,0.0010485124,-0.0157713,0.026500614,0.06535067,0.0105663575,0.007969286,-0.01034972,-0.121521674,0.03759925,0.115189314,-0.06985458,-0.029202623,-0.08773895,-0.020059608,0.004014235,0.008692182,-0.00026291277,0.14850603,0.07145202,0.05557456,-0.08519546,-0.03460805,-0.017010584,-0.09015388,0.011446139,0.096424,0.0015513782,0.01822214,0.04393525,0.040902484,0.03653823,-0.08663272,-0.029440938,-0.057390377,-0.04261035,-0.045913782,0.016991965,0.010597667,0.026974814,-0.011606385,-0.009278372,0.1179472,0.018305758,-0.025850616,0.090463966,-0.026365425,0.004661254,0.097983405,-0.073751576,0.025084209,-0.019491103,0.02133165,-0.04046223,0.0098292865,0.058071416,0.0078394,0.0016972434,-0.04303989,-0.042834863,-0.11620883,-0.022884712,0.05719897,0.007896228,-0.018557638,-0.006794527,0.047192685,-0.046336107,0.052836463,0.039396632,-2.784018e-08,0.030614024,-0.06882806,0.02975011,-0.05363248,0.025322687,0.010260532,0.050401628,0.059022877,-0.02612015,-0.025900867,-0.025251992,0.087420925,0.0023810635,0.0022879292,-0.00050974876,0.007333837,-0.081752814,0.031947196,0.004439585,-0.001043302,-0.060782447,-0.001096515,-0.06414566,0.05990884,-0.031087037,-0.054582108,-0.0016708678,0.039063867,-0.011431827,-0.023080857,0.0524062,0.124211095,0.02363392,0.014201653,-0.12964007,0.023352366,0.06953193,0.02596925,-0.08295951,0.040310856,-0.019432124,-0.022119064,-0.030209908,0.009716046,0.035703927,-0.0030850547,0.05084344,-0.070211515,-0.019804345,-0.015413169,0.0379179,0.061645802,0.0048234584,0.01663001,-0.09408949,0.011638089,-0.036024325,-0.0014637158,0.007928396,-0.09453944,-0.014958704,0.032248054,0.1512447,0.050268274 +4.2.1.1,"The enzyme catalyses the reversible hydration of dissolved CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. At least eight distinct classes exist and appear to have evolved independently. A large majority of the enzymes contain a metal cofactor. Zn2+ is the most prevalent, but Cd2+, Co2+, Fe2+, and Mn2+ are also found [8].",384,0.99999994,-0.040166497,-0.023409544,-0.06790336,0.019946607,0.101396225,0.020052077,-0.058947254,0.019719472,0.0028416917,-0.0003937513,-0.0037839878,-0.096357726,-0.11277541,0.037745178,-0.03544592,-0.050588954,-0.07165063,-0.04384789,0.060672525,-0.029430911,0.034535155,0.04381073,-0.0011687372,-0.013602932,-0.015338524,0.06700584,0.08568345,-0.077513136,0.01626686,-0.05787865,-0.035291195,-0.013043768,0.025384318,-0.03877502,0.044134058,0.06738344,0.020366276,-0.06044771,0.089281745,0.055737846,-0.010721453,0.037851304,0.05720069,-0.06882095,0.024175122,-0.010644595,0.06055321,-0.03160218,0.0038203232,-0.011478671,-0.04101461,-0.03566849,-0.10105633,0.008388316,-0.045816228,0.037309848,-0.03509745,-0.0013487665,0.04509488,-0.05784582,0.0602509,-0.024371563,0.049714703,0.010311781,0.042676125,-0.018536052,0.04123037,-0.058194436,0.037084613,-0.036340907,-0.06917669,-2.092361e-05,-0.041080013,-0.0029458522,-0.03577756,0.05469097,0.0041665263,-0.050373398,0.0055320533,-0.001368345,0.034520883,0.060432103,0.059555493,0.02417257,-0.0026241022,-0.01144136,-0.0026189054,-0.006211192,0.03683443,0.023342028,-0.029409057,0.05919201,0.04894163,-0.05092999,-0.096681364,0.049346205,0.10627258,0.053863272,0.09989637,-0.04629696,-0.0003370989,0.057110034,0.032658648,-0.08246571,0.020260325,0.025976902,0.01940474,0.12491054,0.12384347,0.021425148,-0.05056502,0.04656241,0.0042564096,-0.038955323,0.055223584,0.10458337,0.055438194,-0.06330875,-0.06597636,0.054047793,0.007987743,-0.071037084,0.031993862,-0.0014584671,-0.011345099,0.06338416,-0.15714706,2.025116e-33,0.0398431,-0.00058728235,0.052125562,-0.025035653,-0.0013583092,-0.05753764,-0.077229165,0.0058739316,-0.053554542,-0.03745798,-0.043231953,0.016187651,0.043535545,0.029552344,-0.048865795,-0.0322501,-0.04532215,-0.012405307,0.010719097,0.016947912,0.0043697236,0.062163256,0.015873216,-0.0036734785,0.046990592,0.06875925,0.062357377,-0.0036997881,0.028433006,-0.040250335,0.050970297,-0.12632164,-0.0671929,0.04912207,0.14393635,-0.009449783,-0.030870793,0.028624874,-0.037866954,-0.014940455,0.0023411764,0.017951202,-0.032828305,-0.06810881,0.071123056,-0.11944565,-0.03980075,0.05857205,-0.004105086,-0.016444145,-0.036576357,0.035651505,0.0163502,0.052190416,-0.12596235,-0.016467823,0.03788523,0.017971013,-0.010883687,0.055975147,-0.00030679203,0.08172496,-0.03364064,0.060135167,-0.045497213,0.029488267,-0.044261724,-0.0164806,0.10028386,0.07412912,-0.06624293,-0.0050949957,-0.0004436584,0.043299083,0.02897395,-0.06559975,-0.009373974,-0.053849187,0.051979266,0.03001246,-0.033357654,-0.04304982,0.063524276,0.0065307813,-0.038205083,-0.05555875,-0.08242227,-0.094159655,0.016676286,0.05806182,-0.04907512,-0.031601395,0.026084345,-0.02589685,0.0069673685,-3.4576582e-33,0.108474955,-0.06104826,-0.019744119,-0.1218307,-0.054419745,0.04830522,-0.010632337,-0.085023135,-0.0050963657,-0.040936768,0.06495123,0.034247335,0.13333908,-0.029539298,0.06549602,0.02285861,-0.023820266,0.09260308,0.076944,0.0018497582,0.08090932,0.031196848,0.023505263,-0.02617246,0.09145227,0.03159376,-0.05150711,0.023642948,0.08918883,0.03455534,-0.03903214,0.044830907,0.013286372,-0.07074419,-0.0719448,-0.012290434,-0.08048258,-0.004827519,0.016460737,0.029274398,-0.0010373758,-0.07125232,-0.0052261413,0.058136187,0.039816696,0.019297712,-0.027259016,0.008494796,-0.028682472,0.024418397,0.027624352,-0.019629428,-0.06717319,-0.034042567,0.055512752,0.0810563,0.03355276,0.057592932,0.0031161215,0.048157558,-0.013395545,-0.018359298,0.011369506,0.024884729,-0.0063871923,-0.02664598,-0.016780334,0.01839275,-0.041572828,-0.03502518,0.083780624,0.05044586,0.0022204472,0.011972351,-0.027776964,0.009838526,-0.07269285,-0.04403859,-0.015512954,-0.024021417,-0.017861417,0.041558877,0.06909684,-0.029197956,0.004623359,-0.11122101,-0.009395495,0.02184587,-0.0397496,0.06867497,-0.051715016,-0.10491704,-0.05949251,0.029513985,-0.027190944,-4.314532e-08,-0.071121275,-0.011506439,0.07744457,0.00023146778,-0.0074639125,0.07770434,0.056890473,-0.0092918165,0.0048204227,-0.045675255,-0.011471469,0.032021906,0.05987105,-0.0021530886,0.014215252,0.02327408,-0.058853086,-0.017703673,-0.04938628,0.023878997,-0.017582526,-0.06579356,-0.02902964,0.064913295,-0.012664314,-0.047102798,0.013196231,0.07524692,-0.08655392,-0.03631728,-0.038549732,0.03899742,0.03837894,-0.06630039,0.034821436,0.023810681,-0.011789954,-0.053908072,-0.07762159,0.0043887305,-0.028412396,0.007373217,-0.09222625,-0.010860813,0.034399,0.014518595,0.019838562,0.037832838,0.026866026,-0.04113342,0.03540664,-0.07533301,-0.03635573,-0.067262545,-0.019505475,0.061631,0.0016585911,-0.057998978,-0.041364543,-0.019493604,0.055718563,0.036369607,0.17782453,-0.08183943 +4.2.1.3,"Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds.",384,1.0,-0.027994568,-0.0797702,-0.11353698,0.056033038,0.03780101,0.0030214621,-0.0032375185,0.07593424,-0.014981158,-0.11092451,0.05377158,-0.07210275,0.037025124,-0.04647787,-0.03808319,-0.043306552,0.0785313,0.058872994,-0.015512806,-0.06968094,-0.028889554,-0.042671796,-0.035795677,-0.05845792,-0.0556756,0.031751808,0.010575805,-0.01350776,0.019077454,-0.02588547,-0.06905066,-0.034190502,0.012989406,-0.024450734,-0.04562947,0.030882379,0.020898653,-0.09366879,0.08050649,0.0024937934,0.041927688,0.06843394,0.042598896,-0.008004836,-0.0067440197,-0.017401256,-0.048005994,-0.026988,-0.016540369,-0.008981144,-0.05386321,0.013891107,-0.06819838,0.109885365,-0.02503951,-0.025557192,0.041865416,-0.0032286742,-0.008759401,-0.061138757,0.095901124,-0.04544834,0.02051078,-0.01975657,0.0717434,-0.036479987,0.09523582,-0.0014567578,0.034175333,-0.05565648,-0.071394205,0.047275987,-0.0660438,0.021933554,-0.010548163,0.04333007,0.005937396,-0.07319688,0.044053122,0.03773565,0.0031430637,0.06195307,0.08627385,0.01638135,0.02576245,-0.04657454,-0.023897009,-0.0043939305,-0.036492564,0.035233963,-0.012447954,0.10854692,-0.018392386,-0.022229852,-0.026860513,0.034447894,-0.05504622,0.043514412,-0.01424918,0.01561924,0.011357345,0.067251734,-0.09488194,-0.10604685,-0.055822287,0.020842548,-0.009956188,0.088811845,-0.03108164,0.14452021,-0.08278536,-0.06464761,0.032552224,-0.011642153,-0.019189456,0.11797852,0.033712026,0.0015150051,0.034077104,-0.005526344,0.04059765,0.015305616,-0.021819633,0.03600695,-0.009956562,-0.031002903,-0.04571684,1.3852733e-33,-0.012587962,0.061551273,0.029883435,0.045030966,-0.0389379,0.035720196,-0.11218778,-0.011045788,-0.040798753,-0.010087834,-0.045486398,0.0056849783,0.030967817,0.021979183,-0.07806929,-0.08791558,-0.012745331,0.04965315,0.0658379,-0.03427487,0.025049267,0.08188682,0.009267442,0.005418678,0.035571307,0.06304213,-0.026744662,0.00812115,-0.06763929,-0.027403308,0.022846213,0.024840016,-0.07231914,-0.030760545,0.11877225,0.036416385,0.010738823,-0.029667968,-0.029666396,0.07822701,0.052561004,-0.027601583,-0.0139245065,-0.06259261,0.11841479,-0.0935817,-0.10015879,0.04570644,0.017796332,0.013228153,-0.023083467,-0.0044113803,0.010257634,0.004538378,-0.085217,0.0075334455,-0.0042038066,-0.035394125,0.05125783,0.003949396,-0.020139113,0.01053445,-0.008146413,0.007572374,0.0016164626,0.086456835,-0.16232349,0.00409151,0.030609325,0.10409217,-0.046239138,-0.016890513,0.006312606,0.024066333,0.00032166907,-0.068583235,-0.16452347,-0.009680976,0.008926291,0.021939762,-0.028346311,-0.018993542,-0.041452374,-0.028043669,-0.09094708,-0.07595928,-0.041986033,0.088297345,0.028883921,-0.040369008,0.062408164,0.022041038,-0.008738155,0.03650671,0.0060945177,-3.244246e-33,0.07915737,-0.053279806,-0.0065904884,-0.035719264,-0.06134703,0.03997532,0.0492719,-0.06817856,-0.0032687255,0.059629694,0.11208789,-0.085032254,-0.00045326503,-0.05552842,-0.011111825,0.078697994,-0.0033257212,0.021953333,0.08872638,0.017793097,-0.007911794,-0.042092346,0.041975405,0.09712936,-0.024614614,-0.0148230065,0.028483,-0.033619195,0.10437908,0.12073621,0.00798965,-0.06402065,0.03538198,-0.08122022,-0.081616774,0.039899167,-0.04787228,-0.018984167,-0.02355854,0.0018488034,0.0057412684,0.01904153,0.0046478296,0.07697212,0.036069352,0.041187156,-0.0074894135,-0.05433556,-0.020073226,0.00070316135,0.090498835,-0.012526322,-0.048039846,0.011853682,0.02359868,0.100655206,-0.07742632,0.03357528,-0.029278869,0.0021334416,-0.0010764489,-0.033790655,-0.023300802,-0.05873344,0.0851813,0.0012473135,-0.030598393,-0.00089486246,0.07217672,-0.008293808,0.08088339,0.073028795,0.08232508,-0.090811186,0.025862856,-0.11528707,0.02918311,0.009546252,-0.07207677,0.022291627,-0.0864538,0.0140945455,0.015348056,-0.039368942,-0.053626485,-0.03960364,-0.03141436,0.101658724,0.009490819,-0.0025521396,-0.08307429,0.01792374,0.023270128,-0.009544633,-0.022812273,-4.4596245e-08,0.04567938,-0.058590584,0.03926333,0.038291957,-0.06633763,0.06834264,0.026446873,-0.101703405,-0.06985083,-0.015572325,0.029830694,0.055079818,-0.014244744,-0.04880611,0.07936278,0.025400551,-0.04727465,0.06840585,0.016070593,0.062360276,-0.04471634,-0.032477528,-0.035512805,0.03165306,0.0240705,0.025007626,0.07032127,-0.020702804,-0.02125765,-0.0044748243,-0.027012782,-0.025227578,0.006167578,-0.049142573,-0.040508542,0.045403317,0.012226948,-0.020796796,-0.025037933,-0.042911284,-0.021160044,0.043476675,-0.10236901,-0.0060809148,0.07246992,1.8400486e-05,0.032216694,0.04039866,-0.023571046,0.009861534,-0.024778388,0.014071773,-0.0041038725,0.016746841,0.04796153,0.05320102,-0.004752181,0.007006431,0.015569729,0.040178217,0.027869364,-0.029561974,0.070952594,-0.06419138 +4.2.1.4,"cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. Does not act on isocitrate.",384,1.0,-0.061364822,-0.063532464,-0.069303945,0.020852486,-0.019199677,-0.043167338,-0.02999015,0.015967451,-0.007874131,-0.07015734,0.15003186,-0.079835705,0.008547757,-0.031943712,-0.015705302,-0.035495702,0.09640108,0.025633784,0.017262105,-0.008890608,-0.026560599,-0.028818281,0.00496947,0.019264149,-0.0071475306,-0.036730908,-0.040517982,0.0424555,0.030772267,-0.008169883,-0.0022738585,-0.025874594,-0.00803189,-0.013719049,0.0061673126,-0.017296009,0.018982468,-0.07886348,0.084691174,0.069370866,0.06602515,0.0054785726,0.045415502,0.027698219,0.016116418,0.013780365,-0.03704883,-0.05891516,-0.076106235,-0.010130915,-0.018504577,0.0011327819,-0.04538872,0.07093488,-0.04003274,-0.031244213,0.05074272,0.032070164,-0.03710043,-0.05159729,0.024986202,-0.04081284,0.014167375,-0.051094156,0.05507169,-0.031007137,0.047745775,-0.049753744,0.015475247,-0.023014883,-0.044270538,-0.03920906,-0.027440408,0.04040117,-0.02775318,-0.06307779,-0.047808543,-0.04468534,0.046645124,-0.029696014,0.03010828,-0.011888731,0.045973983,-0.06271107,-0.015621415,0.01194447,-0.020399932,0.054771,-0.028279686,0.027101072,-0.014428458,0.06938616,0.03613273,-0.017753059,-0.06286722,-0.008980896,-0.012506624,0.04708481,-0.040830266,-0.010047869,0.074684255,0.022821326,-0.16239423,-0.052351218,-0.05793199,0.03429347,0.0046742395,0.011326329,-0.037462972,0.16024572,-0.12239765,-0.05775144,0.035434466,-0.010197282,-0.04642135,0.100627884,-0.062455542,0.053518206,0.09733447,-0.018364659,0.037068333,-0.095849864,-0.064191766,0.039571382,-0.02939667,-0.015775064,0.04072522,-1.553073e-33,-0.048961636,0.07297355,-0.022173677,0.023896687,-0.054111466,0.066544354,-0.047658302,-0.03685311,-0.0730917,-0.087236464,-0.061841276,-0.036047682,0.03302003,0.02832611,-0.10587878,-0.07739142,-0.05910135,0.07753639,0.01699938,-0.060229544,0.06610129,0.07751349,-0.041842073,0.04263045,-0.010892457,0.04084127,-0.057694986,0.023883196,-0.024876323,-0.014459383,0.025313322,0.018245373,-0.051014625,-0.03947383,0.09622084,0.059681106,-0.0012738312,-0.039304428,-0.02113914,0.055806324,0.043900777,-0.01947192,-0.04221316,-0.0073214583,0.08529007,-0.019244147,-0.07293197,0.045476746,-0.019074695,0.00027940207,-0.003347958,0.0017189988,-0.05470898,-0.0013223296,0.0074473573,0.03301553,-0.018679066,0.048482466,0.02868095,-0.022302538,-0.010941361,0.02563768,0.01159423,-0.043242987,-0.019398766,0.12879035,-0.15895276,-0.017579302,0.049256273,0.08056645,-0.0011547599,-0.013006146,0.031142794,0.044322927,0.06254339,-0.030241644,-0.11724221,0.008789889,-0.01729403,-0.01389635,-0.12506953,0.032035846,-0.010669603,-0.012996689,-0.031207012,-0.06924368,-0.002361791,0.11358938,-0.004781582,-0.006864953,0.09938546,0.015867895,0.008595034,0.02662627,-0.006607299,-1.4379157e-34,0.04545746,-0.03096133,-0.017622422,-0.036421128,-0.011758686,0.020352194,0.009759886,-0.058398698,0.048613943,-0.010006366,0.13004154,-0.053036008,-0.03735287,-0.001497023,0.014273758,-0.019732535,-0.016423924,-0.01889728,0.050944034,0.045338698,-0.0018811307,-0.09880116,0.005660095,0.13478981,-0.07265834,-0.003868103,0.06732428,-0.03812897,0.07356604,0.055262472,-0.024152022,-0.03357476,-0.0016393536,-0.038767282,-0.013909507,0.10734331,-0.027747327,-0.018412227,-0.13452636,0.023629138,-0.06764936,0.027831031,0.0064106383,0.0633325,-0.010254776,0.039412465,-0.0039588185,-0.028895695,-0.041728035,-0.009794443,0.039913956,-0.0016851837,-0.024710193,0.0054177917,0.08131759,0.10958924,-0.09414659,-0.0045293416,-0.008798114,-0.03136234,-0.0064730933,0.019021671,-0.032271814,-0.019624095,0.057690218,0.0056647584,0.000934004,0.016158927,0.10988758,-0.04399026,0.13805838,0.0734924,0.055347227,-0.03908714,-0.054040305,-0.13642767,0.02513678,-0.02703398,-0.086282276,-0.0012890697,-0.051734276,0.021308132,0.007161916,0.04238259,-0.06468498,-0.033543333,-0.0404606,0.055800743,0.019566175,0.016432287,0.001226235,0.035918135,0.040981174,0.040530186,0.012684576,-3.254162e-08,0.03962126,-0.021123325,0.054961424,-0.0030994515,-0.037840214,0.027171979,0.011449937,-0.119853556,-0.013984644,-0.067384414,0.05477747,0.015221889,0.034329336,-0.027607974,0.1395668,-0.008744775,0.03717432,0.10342575,-0.009610894,0.05929671,-0.06133223,-0.005752862,-0.024521314,-0.01686745,-0.01561212,0.09093238,0.09150001,0.016369356,-0.010108432,0.017500844,0.022745743,-0.0235875,0.064350806,-0.00973485,-0.0021102547,0.060176805,0.025799602,0.013431552,-0.0104531525,0.008153755,0.005280827,0.005068675,-0.054266088,0.009682265,0.08092838,0.023795953,0.013806576,-0.02893856,-0.026063526,-0.008482043,-0.06922419,0.046160895,-0.051726438,0.02763177,0.053071707,0.020434089,-0.050473154,0.002711844,-0.014278511,0.0138874445,0.075632185,0.034018166,0.12249133,-0.007549837 +4.2.1.6,"The enzyme shows no activity with D-gluconate [2]. cf. EC 4.2.1.140, gluconate/galactonate dehydratase. ",384,1.0,-0.032388654,-0.10050005,-0.040936925,-0.07801506,0.026030617,-0.03438593,-0.062854774,0.038153533,-0.024160324,-0.027096327,0.00284914,-0.050722465,-0.07867569,0.09558842,-0.06832267,0.00070150255,0.025127474,-0.052110497,0.026547557,0.018249027,0.08342735,0.000116508934,0.021836668,0.012176972,0.12591678,0.014880244,0.061661925,-0.02723051,-0.063308924,-0.058528308,-0.019746972,-0.024633171,0.04411482,0.017197788,0.058038335,0.097087964,-0.02886815,-0.010122327,0.0048237164,0.014257272,0.011943704,-0.032882843,-0.00013250396,-0.003952612,-0.016454117,-0.015807413,-0.01663799,0.025815258,-0.026453082,0.019974018,-0.034092903,-0.10341263,0.015640154,-0.011114598,0.01911425,0.027713038,0.010170244,0.014698397,-0.072653934,0.008543768,0.065101765,0.02858341,0.023632506,-0.013037552,0.0032117227,-0.013808171,0.032848876,-0.033136886,-0.005887454,-0.04856534,0.0417697,-0.09538473,-0.01221015,0.008318095,-0.0056181946,-0.02374405,-0.0063640065,-0.058172207,0.044013176,-0.074674964,0.035025306,-0.023125669,0.046019692,0.051765837,0.02513463,-0.006632081,-0.033747073,0.026276864,0.045634463,-0.057849005,0.020855017,0.01364188,-0.11223192,0.013154485,-0.030504866,0.038643084,-0.029236013,0.044518355,-0.021138405,-0.037189793,0.0043516103,0.059819397,-0.07078652,0.011733421,-0.0033149307,0.0532276,0.070268005,0.08705427,-0.025855837,-0.041742176,0.037297104,-0.0053855204,0.07633097,0.09593856,-0.07060047,0.039466232,0.07067502,-0.034581173,-0.14497176,0.035408605,0.042627923,0.0020505597,0.113065995,0.019586788,-0.018196022,0.10522166,-0.034333184,-2.7039263e-34,0.074898526,-0.049728137,0.0212296,-0.015393081,0.033479393,0.063182876,-0.054895565,0.00052773446,0.006107326,-0.013184685,-0.083240904,-0.014042765,0.03140923,0.023866907,-0.033686344,0.061947152,0.11332214,-0.04636217,0.04098065,0.015999695,0.128385,0.060271855,-0.08661637,0.04847976,-0.001567049,0.05800541,0.02265902,0.056930333,0.08963957,0.00034589335,-0.08421139,-0.13210408,-0.016755354,-0.011481398,0.009327274,0.03321326,-0.10007374,-0.021455016,-0.013694425,-0.025121499,0.01598108,-0.016026672,-0.0067053963,-0.0886412,-0.011588882,0.016145835,-0.0061381827,0.07101166,-0.01969523,0.082461886,0.06937807,-0.037524603,0.0011702841,-0.024521518,-0.028719576,0.058295134,-0.061190806,0.03858969,0.053944156,0.07941965,0.023838531,0.07109635,-0.043820705,0.015663927,0.008376204,0.01376838,-0.049987856,-0.01559239,-0.05358184,0.02602188,-0.05553213,-0.056014594,0.054983165,0.05167812,0.017687293,-0.07666759,-0.0029243762,-0.049592897,-0.0008982059,-0.057271216,0.03956709,-0.042106267,0.025211822,0.011924105,-0.027791597,0.025252875,-0.040762737,-0.026445895,-0.039077416,0.05294674,-0.02219367,-0.019934606,-0.08209159,0.017088085,0.0037040303,-9.646324e-34,0.0491688,-0.056996077,0.055838548,-0.046229742,-0.024641747,0.112751245,0.036922574,-0.024269685,0.09632738,-0.030305393,0.119050264,-0.0041664517,-0.10818371,-0.061167937,-0.043925818,0.0805116,-0.057641886,0.02006096,-0.043869693,0.027965585,-0.014284869,0.11980048,0.0059312796,0.050126944,0.050745625,-0.0056752586,0.06423122,0.076575406,0.024059813,0.0055762148,0.041230742,0.05143392,-0.033085644,-0.11061709,-0.06163455,0.057619408,-0.07304666,-0.04286373,-0.034744095,-0.009382017,-0.016701646,0.044177663,0.014916018,0.06925814,0.029196186,0.09323831,-0.07875065,-0.009849511,0.005656881,-0.028182782,0.030068757,-0.06509318,0.016101757,0.04204582,0.05734053,0.0074669523,0.11078114,0.047163863,-0.028700778,0.01984601,0.01185429,-0.039231632,-0.0048683546,-0.058631975,0.06642543,0.005077792,-0.035286114,0.12148502,0.065726906,0.00972701,0.06371619,-0.019334314,-0.03299157,0.032073464,-0.0420778,0.03520547,-0.13349019,-0.021367136,0.03222087,-0.11178844,0.01883716,0.021790368,-0.004034331,-0.027577365,0.021714207,-0.050381914,0.026504477,0.0986382,-0.014206882,0.08072635,-0.06306707,-0.020483332,-0.029164393,0.030911567,0.07324229,-2.8930522e-08,0.06609137,0.0023031363,0.05148369,-0.09818291,0.007244476,-0.028280001,0.026950015,0.006874622,0.03679532,-0.0015711797,-0.07559267,0.053425103,-0.05773257,0.008597291,-0.024158362,0.017337987,0.014655226,0.002188313,-0.047258038,0.0031582105,-0.03526165,0.010389405,-0.17909336,-0.008846768,-0.01930705,-0.042381626,0.03746741,0.05124295,-0.0029671262,-0.08027367,0.03175992,0.050684746,0.05902298,-0.038654797,-0.07595629,0.026636763,-0.053748917,-0.007935697,0.005584178,0.016707312,-0.034845013,-0.052660387,0.033644818,-0.022305833,-0.05542258,-0.00642488,-0.008582433,-0.002304178,0.012876314,0.045971196,0.037245557,-0.0014568814,-0.06107723,-0.038752012,-0.069700204,0.03360969,0.02008952,-0.055415098,0.009421065,-0.11249048,0.057146512,-0.12871231,0.036601514,-0.035149124 +4.2.1.11,Also acts on 3-phospho-D-erythronate.,384,1.0000001,-0.025085721,-0.086463355,-0.03913181,0.011030725,-0.012294518,0.017401315,0.07240904,-0.0041251085,0.06279251,0.061775077,0.047311157,-0.017755574,-0.08708165,0.06628509,0.0825034,0.05676694,-0.03750372,0.082969636,-0.04784272,0.010912001,0.08605421,0.017197601,0.067643456,0.02256866,0.0045869015,-0.0129897995,0.01075107,0.01965526,0.02160221,-0.098598935,-0.02760134,0.007859748,0.037802257,-0.019083422,-0.001751122,0.06107468,-0.09593555,-0.021663394,-0.019435504,0.043112624,0.089631274,-0.019222096,0.03077073,-0.013682219,-0.08086409,0.030461986,-0.10743689,-0.00011097438,0.07501305,-0.036112368,-0.04018304,-0.06167025,-0.070163205,0.09937641,-0.06378762,0.046618465,-0.08154353,0.056355502,0.02846272,-0.0067445235,-0.0073134154,0.021641694,0.03901602,0.048106845,0.07331648,0.040757414,-0.012489581,-0.10572032,-0.05683923,0.015681753,0.029108074,-0.066925354,0.01889447,0.0041539012,0.039942086,0.04427996,0.017082293,-0.013275557,-0.066489175,-0.047372743,-0.016472736,0.037158363,0.011163984,0.064306624,-0.02807222,0.07015662,-0.09631963,-0.053146556,-0.09089215,0.021592217,0.010315357,-0.0818919,-0.024272947,0.006929448,-0.052818187,0.03599314,0.0011222016,0.010892005,0.0014913707,0.011462011,-0.009960721,0.06254349,-0.03826944,-0.039037395,-0.015443283,0.008894517,-0.03306039,-0.043009892,-0.0834576,-0.016452383,-0.012183851,-0.058702238,0.06673635,0.007640864,-0.071268946,0.09650137,-0.0069285715,-0.0037045733,-0.028662993,-0.0020151578,0.07435219,-0.08874658,0.0072733113,0.040221706,-0.07228353,-0.00683604,-0.057459712,-3.8044073e-34,0.082483694,-0.003020293,0.017744398,-0.013153993,0.039971225,0.01681601,-0.09105213,-0.07532745,-0.006691778,-0.06459631,-0.07640824,-0.049770325,0.08955432,0.03143111,-0.06131026,0.011330787,-0.028501198,0.052548535,0.013425038,-0.050388608,0.06701666,0.071137734,-0.068479225,0.010245927,-0.043284763,0.085971996,-0.03976558,0.012354332,0.03329979,-0.0047633257,0.09103032,-0.028273797,-0.044428904,0.025562748,-0.044680655,0.060603786,-0.08158097,-0.031106705,-0.042665154,0.0048738155,-0.020390952,0.0080573615,-0.106383115,0.049326334,0.07053796,-0.073067926,-0.058015432,0.037377544,0.08835378,0.023972899,0.016880015,-0.036851246,0.10731694,0.010171771,0.0026194046,-0.012062727,0.015476667,-0.025591662,0.04394745,0.040248893,0.010918306,0.033812355,0.0025880071,-0.012717117,8.0064594e-05,0.056554317,-0.09980296,-0.07343927,-0.032701243,0.04428435,-0.037626207,-0.043704093,0.09080975,0.025526728,-0.022455709,-0.061374906,1.1679148e-05,-0.05106473,-0.034103505,0.052107986,-0.016773788,-0.037620176,0.036713123,0.055364367,-0.018793635,-0.0123344725,-0.013361486,-0.1313194,-0.06009431,0.03687381,0.07020337,-0.03457717,-0.041049838,-0.035312798,-0.03922514,-4.5609167e-34,0.02859248,-0.0013503679,-0.010440747,0.025957992,0.031870488,0.042741004,-0.01006648,0.08390332,0.007625832,0.01542195,0.09531359,0.003404059,-0.06044896,-0.057514474,0.05680438,0.054806195,0.061276548,0.08279411,0.035422865,0.034230795,-0.026890531,0.06670349,-0.003966889,0.11067032,0.03733051,0.031345386,0.006222917,-0.051829927,-0.03338758,0.08020686,-0.010926756,-0.0055901473,-0.10180421,-0.025062492,-0.031131964,0.04690254,-0.030953787,-0.004719877,-0.054418705,-0.037374396,0.040552013,-0.027769668,0.13206565,0.058945805,0.04465273,0.07833791,0.0031874392,0.08864373,-0.097785994,0.038926337,-0.018183725,0.0015473604,-0.010349371,0.0346039,0.089661345,0.06593071,0.023678044,-0.035035495,-0.069715194,-0.021972923,-0.025323294,-0.046086222,0.019355526,-0.05602341,0.05098581,0.056913264,-0.015873604,0.0649781,0.0333758,0.027666776,0.081917726,0.020672916,-0.01996385,-0.023614058,-0.06433483,-0.07026011,-0.083956935,-0.04316151,0.014663244,0.004309823,-0.047240753,0.025083795,0.010699097,-0.0070011625,0.0066849776,-0.054861173,-0.033166204,0.071757145,-0.04187611,0.04789598,-0.010897969,-0.011507232,-0.0143913375,0.04778666,0.111830555,-2.3439242e-08,0.08624585,-0.026364326,0.031478703,-0.077896625,0.0060827024,-0.033959746,0.06610467,0.05703503,-0.042019576,-0.007656873,0.019334655,0.025385419,0.085195154,-0.044415664,0.16347261,-0.011310581,0.01994138,0.094471455,-0.08197529,-0.032740396,-0.04687064,-0.023859683,0.008694034,-0.017636921,-0.016160531,0.006134252,0.029574724,-0.006146178,-0.03749513,-0.02061138,0.08475784,-0.06149613,-0.029481677,-0.019984676,-0.05223444,0.020711374,-0.07041704,-0.05053671,-0.044618163,0.02780178,-0.057504084,0.023479315,0.015054537,0.09211732,-0.05419837,0.011457149,-0.004685027,-0.06048413,-0.028242245,-0.015001503,0.0040841205,-0.035273056,0.017590042,-0.06696931,-0.1505426,0.039100006,0.019331174,-0.014599972,0.013772269,-0.020939631,0.0719052,0.023189884,0.10342995,0.035082232 +4.2.1.17,"Acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA. cf. EC 4.2.1.74 long-chain-enoyl-CoA hydratase.",384,1.0,-0.082684614,-0.056421746,-0.009672889,-0.028698768,0.07596403,-0.038722537,-0.06922991,-0.012941908,0.04613992,-0.06658568,0.037263133,-0.09229151,0.01564097,0.0060447683,-0.00589324,-0.007971415,-0.041971724,-0.0060172807,0.007668995,0.012805807,0.018711463,-0.018400734,0.015191805,0.11521432,-0.02095544,0.045938,0.07570884,0.025875667,-0.012888456,-0.084910996,-0.0030498041,0.05068925,-0.006096192,-0.08571357,-0.012614678,0.0489969,-0.014886324,-0.040504865,0.05871959,0.020938743,0.05649086,-0.10539037,0.034695562,-0.0038020483,-0.049294583,-0.0460629,-0.0869523,0.02221743,0.09248632,0.015417155,0.035372615,-0.03608145,-0.10257309,0.07777578,-0.015224337,0.036318813,-0.041607186,0.031222481,-0.03578817,0.0570419,0.09489641,-0.056811705,-0.024096902,-0.01252811,0.02427287,0.03272244,0.030841326,-0.0064396644,-0.0035097345,-0.004312801,-0.060150184,-0.06135944,-0.0055432264,0.0013017405,-0.040676884,0.040097293,0.034648295,-0.021089584,0.004634084,-0.057507526,-0.005683723,0.049964346,0.051192876,0.08447965,0.059947383,-0.010789791,0.0053172554,-0.03150868,0.062153526,0.046100713,-0.03295727,0.020029247,0.010471642,-0.044205654,-0.05870898,0.08863391,-0.0007338538,0.04549154,0.008301336,-0.011696799,0.053845894,0.103876315,-0.08678738,-0.09780774,-0.025158357,0.039647855,-0.035467662,0.13811271,-0.020504111,0.026624877,-0.05204101,-0.061679788,0.074956425,0.028256606,-0.07569137,0.078746244,-0.050731253,0.0003377222,-0.056059107,0.022162672,-0.0016499662,-0.0025810702,0.031919092,0.008923315,-0.001127419,-0.021138804,-0.015214634,-2.026405e-33,0.022554226,0.0084641045,0.057401765,0.067070305,-0.041558225,0.03150333,-0.07120547,0.0020990274,-0.13922992,-0.041022286,-0.018535193,-0.027347848,0.04983903,0.024716904,-0.030351048,-0.10333635,0.010175031,0.0772749,-0.022773704,-0.014006928,0.038390364,0.066364296,-0.041488435,-0.012361432,-0.047934476,0.024838656,-0.0049494402,0.050128642,0.05619917,0.013629308,0.029210672,-0.02809831,-0.01838891,-0.024173852,0.02050851,0.016318973,-0.054095086,-0.03040814,0.008323348,0.15362926,0.033348233,0.015124233,-0.0106963115,-0.038432162,0.008547801,-0.004174247,0.0334651,0.075483255,0.044355378,-0.010167452,0.023506628,-0.00021944263,-0.04486132,-0.01898634,-0.010920053,0.013962454,-0.028082768,0.039204806,-0.0021743479,-0.010959931,-0.0012585266,0.101012014,-0.06726251,0.010247646,-0.01197304,0.031105783,-0.09757023,-0.0018377104,-0.019556448,0.021508697,-0.014528647,-0.0018904734,0.06509419,0.08402237,0.10502531,0.0066912565,-0.11927374,-0.056428555,0.027843354,0.027563376,-0.09096603,0.022838278,0.048192747,0.06977522,-0.036801863,-0.006369172,0.04604585,-0.034292266,0.049095582,0.06624779,0.027293468,-0.10882275,0.012324003,-0.0023985114,0.0040250034,2.2591786e-33,0.09433208,-0.07603127,0.015040752,-0.12533778,-0.043157686,-0.006996586,0.027048366,-0.06469501,0.07643673,0.044889186,0.16462883,0.032494437,-0.041217458,-0.040468372,0.04734553,0.01087533,0.07279633,-0.039209645,-0.048458826,-0.0333122,0.06474587,-0.055098727,0.03567426,0.058299348,-0.0012240846,0.062641114,0.09639874,-0.007325854,0.07311205,0.114546336,-0.05540829,-0.034411237,0.020601053,0.06879802,-0.013767204,0.06570924,-0.08020595,-0.042396273,-0.0142473215,-0.033637866,-0.07621959,-0.014472508,0.056234848,-0.011001199,0.010398639,-0.01113156,-0.050976925,0.044077642,-0.0026308931,-0.057875562,0.0058676675,-0.0064490917,-0.041117355,0.009594447,-0.013337526,-0.011126166,-0.019404037,-0.023085432,0.023186252,-0.046389185,-0.011973896,0.069030434,0.03560558,-0.077861995,0.013554976,0.054216035,-0.06424097,-0.007883741,0.066137776,-0.032943003,0.07509457,-0.024972009,0.028386729,-0.008689184,0.04417212,-0.07978117,-0.05310755,-0.0597485,-0.046701163,-0.033495184,-0.057258137,-0.029865766,-0.011941639,-0.026604211,-0.09689933,-0.08870175,0.017243274,0.056936257,0.012539748,0.03382869,-0.033770617,-0.00711162,-0.0026688015,0.12502672,0.14415547,-3.0904438e-08,-0.028567463,-0.09185349,0.04731256,0.041861925,0.021733932,0.08612688,-0.007692477,-0.007069213,0.075766355,-0.017380547,0.028977968,0.023921456,0.08282638,-0.008358214,0.028454853,-0.00028930762,0.071828105,0.018834895,-0.030479517,-0.11534393,-0.08631959,-0.047427684,-0.015104772,-0.029255873,-0.007066539,-0.009687734,-0.008547269,0.018047765,-0.04379866,0.016725233,0.03892408,-0.03433661,0.0011010038,0.041122563,0.037583,0.050960187,-0.021554684,0.018055184,-0.004062332,0.083361246,0.034526724,0.012161785,-0.07720332,0.056023665,0.049674794,0.0030412634,-0.015448852,0.071960986,-0.06018207,-0.045582883,-0.009868556,-0.023990037,-0.0012452701,0.018242303,-0.031972516,0.025718847,-0.06728322,-0.055368807,-0.086048506,0.007855318,-0.017624216,0.016030625,0.1667583,-0.045753043 +4.2.1.20,"A pyridoxal-phosphate protein. The alpha-subunit catalyses the conversion of 1-C-(indol-3-yl)glycerol 3-phosphate to indole and D-glyceraldehyde 3-phosphate (this reaction was included formerly under EC 4.1.2.8). The indole migrates to the beta-subunit where, in the presence of pyridoxal 5'-phosphate, it is combined with L-serine to form L-tryptophan. In some organisms this enzyme is part of a multifunctional protein that also includes one or more of the enzymes EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase). In thermophilic organisms, where the high temperature enhances diffusion and causes the loss of indole, a protein similar to the beta subunit can be found (EC 4.2.1.122). That enzyme cannot combine with the alpha unit of EC 4.2.1.20 to form a complex.",384,1.0,0.0071953465,-0.12055027,-0.040944733,-0.022843847,0.077124625,0.060634542,0.026403973,-0.013175248,0.12547892,0.062473983,0.025090678,-0.019508965,-0.0992174,0.0974892,0.015914248,-0.024553176,-0.056463357,0.02406877,-0.06325643,-0.08070998,0.094214045,0.019913556,-0.009466184,-0.0094450265,-0.007242208,-0.0025261939,0.0044077383,-0.060608853,-0.09208028,-0.025477976,-0.013946882,-0.070692375,-0.008075771,-0.02408614,0.054251175,0.10284178,-0.10152663,-0.045786016,0.025624545,-0.024868786,-0.021902451,-0.040557917,-0.044298816,0.0026575548,-0.07347492,0.039941277,0.02709494,0.0017931156,0.10435784,-0.09804525,-0.05566956,-0.047653016,-0.041368313,-0.017811658,-0.035720747,-0.011887323,0.0028024146,0.051981825,-0.06224942,-0.0004845799,-0.053313628,0.05792599,0.012815499,0.021732707,0.024483947,-0.06531179,0.07497964,-0.0525017,-0.016360085,0.05427341,-0.069186285,-0.017431198,0.016626611,-0.0009190047,0.008373597,0.06464889,-0.007211458,0.0072379257,-0.03934161,-0.035948288,0.041967876,0.023374088,0.020753546,0.053940367,-0.02681946,-0.023340076,0.015108295,0.037336163,0.058682326,-0.041097146,0.032696996,0.02469214,-0.012077896,0.037747484,0.045394424,-0.0034295046,0.048670672,0.029400103,0.026444709,-0.08839731,-0.02764177,0.010067811,-0.06739709,-0.052791666,-0.012888437,-0.0043710503,-0.03646322,0.019930283,0.045119178,0.021670328,-0.06723327,0.029614147,0.057951022,0.057005282,-0.005154529,-0.0032677937,-0.02971052,-0.0050300807,-0.0283955,0.04404525,0.0050850967,-0.00019565113,0.0456505,0.13212292,-0.05134945,0.042891018,-0.09279271,1.8891032e-33,0.100816496,0.07654822,0.031111285,-0.0025559945,-0.011601209,-0.03536994,-0.076455995,-0.029345088,-0.043749698,-0.022503458,0.003906775,-0.03849786,0.07533929,-0.017642852,-0.024779642,0.030495627,-0.123149425,0.057395305,0.049447987,0.01977251,-0.024203308,0.042040743,-0.018805329,0.049305808,-0.03800903,0.071028404,-0.021041555,0.014862204,-0.029052101,-0.007290862,0.0073840213,-0.11285594,-0.13684559,0.044143774,0.0035432554,-0.06143246,-0.037551995,-0.037005726,-0.04648699,-0.0007026168,-0.0039624916,0.0023824107,0.020029606,0.053258605,0.064678036,-0.01745596,-0.06020912,0.13793208,0.015049767,0.038018666,-0.010644028,-0.075898185,0.12795392,-0.038500156,-0.07832826,-0.042983215,-0.020387877,-0.028393134,0.0030349009,0.020638578,-0.024427176,0.026945924,-0.028450176,-0.022338126,0.016644344,-0.027678303,-0.02623064,-0.08438755,0.014766515,0.08174451,-0.02883135,0.00785733,0.09109884,0.050546553,0.019246936,-0.050440386,-0.015200453,-0.01331858,-0.041215196,0.030864965,-0.06265444,-0.031138647,0.008084393,-0.06324007,-0.013430649,-0.04426799,-0.013807413,-0.05939061,0.005493505,0.05320534,0.04624039,-0.11124382,-0.0936825,0.11739546,-0.013084563,-2.831379e-33,0.09117033,-0.10334079,-0.004443649,-0.038698606,-0.06665929,0.023101315,0.06355336,0.046298012,0.039757762,-0.039201207,0.022910524,-0.02341319,0.09707801,-0.020855116,-0.017019697,-0.06530429,0.017058078,0.082912214,0.07221232,0.07227502,0.0009724778,0.05487556,-0.02413144,0.0626976,0.07264552,0.028498195,-0.06557418,0.09200959,-0.057451207,-0.0019547297,0.101231046,0.03208755,-0.08629782,-0.056376953,0.0044157645,0.056657363,-0.079955645,-0.0060959067,0.060282346,0.05980559,-0.00798526,0.06412364,0.08890161,-0.05582693,0.056567177,0.09082172,-0.0353877,-0.0055872956,0.02291066,-0.007932362,-0.0069452412,-0.02413299,-0.035547927,0.02252984,0.033313073,0.057945695,-0.07823887,0.0710432,0.0011842091,-0.021423228,0.0020545213,-0.087879844,0.0950025,0.07027425,-0.01236983,0.051066864,0.003949201,0.031580035,0.100372314,0.070009276,0.027519511,-0.029995149,0.05427048,0.047219314,-0.018136974,-0.05319866,-0.0691346,0.006526852,0.017458191,-0.0067979204,-0.0064475583,0.10213912,-0.015296991,-0.068622164,0.04224493,-0.02291274,0.027397435,0.13747509,0.0143958675,-0.026643533,0.040460695,-0.05614193,-0.008643834,0.06928379,0.09139502,-4.9744415e-08,0.09758616,-0.034349576,0.033516467,-0.026500398,0.018471694,-0.0022765722,0.038538877,0.021321816,0.04555349,-0.04775469,-0.01213291,0.044342786,0.03260051,-0.00093090115,0.017438676,0.0013958778,-0.03636412,0.009662408,0.0153231425,-0.06056641,-0.038167723,-0.061921872,-0.090459384,0.046117432,0.049015924,-0.009068287,0.04244643,-0.02223741,-0.024200374,-0.05516922,-0.03187909,0.0034993964,0.0072117494,-0.026206361,-0.04352293,0.059957284,-0.055196468,0.041490678,0.009500547,0.02444776,-0.02644264,-0.06511342,-0.03639991,0.002676416,0.07420509,-0.00088486203,-0.033779256,-0.021901561,0.011120609,-0.057869192,0.06491393,-0.006612789,-0.054516006,-0.058259293,-0.14428581,-0.016165141,-0.015110836,0.0038022439,0.012734714,-0.045828912,0.0068267807,-0.009826713,0.07002107,-0.03407551 +4.2.1.22,"A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses beta-replacement reactions between L-serine, L-cysteine, cysteine thioethers, or some other beta-substituted alpha-L-amino acids, and a variety of mercaptans.",384,0.9999999,-0.018380517,-0.08220626,-0.020299086,-0.03480489,0.09904538,0.07997348,-0.0022417444,0.02324889,0.0880058,0.024445217,0.02162117,0.011533004,-0.0873224,0.06580628,-0.007491417,0.023581298,-0.13585423,0.042883564,0.023455165,-0.050754603,0.053093243,0.038443588,0.01930583,0.038067836,-0.008135214,0.08011838,-0.0007412762,0.006972437,-0.042038064,-0.026463708,-0.05316514,-0.018740375,0.032284256,-0.05252533,0.008610415,0.12876546,-0.13842283,-0.04492243,-0.007046677,-0.037289426,0.045317784,-0.054605205,-0.07088051,-0.021352105,-0.080719426,-0.008619241,0.06308266,0.022725077,0.06467474,-0.005889574,-0.069308616,-0.0676455,-0.06488285,-0.017532162,-0.019042704,0.0144015765,-0.00074020156,-0.040674094,-0.019926952,-0.020378299,-0.0025177824,0.03328479,0.009502786,0.006184397,0.10836817,-0.017426379,-0.022190036,-0.059241902,-0.01735482,0.020765493,-0.09711391,-0.054010782,0.044868104,0.037591353,0.0020595626,0.00970446,-0.05454639,0.0078049903,-0.024961717,0.03609911,0.032744452,-0.013504177,-0.008076441,0.034298964,0.0960958,-0.003720135,-0.0282828,0.014486001,0.055290956,-0.03614412,-0.012567675,0.012238935,0.0030399107,0.004804209,-0.02987358,0.0070636473,0.008831542,0.019398443,0.039617162,-0.014727995,0.0068294387,0.040096894,0.0095667895,-0.11155811,-0.05238853,0.025247548,-0.06824873,0.042387635,-0.026646279,-0.052292526,-0.07143811,0.011959903,0.02245632,0.042352755,0.008560995,0.06795357,0.043763667,-0.01735253,-0.013477769,0.017184656,-0.006664085,-0.022430565,0.061876684,0.08065287,-0.04996572,0.014139447,-0.14581402,2.5513827e-34,0.081831545,0.09137124,0.035311677,0.020649476,-0.005794064,-0.023692654,-0.033404276,-0.024509996,-0.049722455,0.011659912,0.005972033,-0.01858836,0.04386493,-0.0024863023,-0.0053760977,-0.04668894,-0.02886536,0.05006648,0.14285526,0.003743726,-0.01725577,0.06202998,-0.0044972505,0.08006901,0.005822942,0.13165188,0.007870355,0.027951203,-0.0073344912,0.0020823025,-0.0047863037,-0.024916021,-0.09692983,-0.025355028,0.039539676,-0.102340296,-0.0837917,-0.07885757,-0.016924577,-0.0019041898,-0.0652168,-0.059872925,-0.035327695,0.008936261,0.010279534,-0.09696198,-0.050447926,0.08003243,-0.023483597,-0.020689372,0.0314564,-0.06567775,0.062040456,-0.057175823,-0.13474819,0.0048600547,-0.06220396,0.006513934,0.006064957,0.08254945,0.03267384,0.0055387896,-0.07039318,0.026228748,-0.003526731,-0.014186403,-0.004810558,-0.043869626,0.06165048,0.08892221,0.048168708,0.014477703,0.06463673,0.06634055,0.021479836,-0.048034627,-0.07543392,0.008052572,0.018741315,0.07412767,-0.036881473,-0.01735147,-0.055865366,-0.012335194,-0.029051645,-0.034836743,0.021645624,-0.09234148,-0.017114785,0.016807986,-0.020105314,-0.08483714,-0.046019223,0.009439184,0.008745324,-2.8903252e-33,0.0673664,-0.09050362,0.008393376,-0.02790974,-0.06828967,0.0072158696,0.06520107,-0.060195036,0.0014606479,0.01999503,-0.016393783,-0.03805504,0.038052894,-0.079156615,-0.035736315,0.029752389,-0.0012072516,-0.05778942,0.036187313,-0.0030212163,0.03548833,0.04826839,0.061267044,0.06573886,0.051428672,0.036647346,-0.0063142655,0.07030096,-0.0066190045,0.05373696,-0.009092611,0.04078332,0.06916778,-0.061564457,-0.044379566,0.032910615,-0.024247536,-0.004601034,0.055561196,0.06851595,0.046090398,0.027292596,0.08299407,0.033647757,0.03486144,0.04564091,-0.061266713,-0.003729269,0.0108753545,-0.0826759,0.015195505,0.047696598,-0.0169997,-0.03682287,0.013770506,0.058022,-0.075936615,-0.04631398,0.028491085,-0.017645182,-0.007990971,-0.111900106,0.042220935,0.11267609,0.044764515,0.030924361,-0.017359376,-0.08507224,0.053710718,0.054568484,0.11625996,0.003280629,0.047659356,0.08334129,-0.009376155,-0.017098531,-0.06670969,0.04489662,-0.002768928,-0.024931293,-0.014812412,-0.04786041,-0.01083652,-0.08533387,-0.016499775,-0.08109044,0.07415888,0.1421382,-0.00952171,-0.031519707,0.016998168,0.017682353,-0.04681068,0.07885633,0.104281075,-3.955503e-08,0.065999515,-0.06631729,0.0041603376,-0.05938928,0.0058888188,0.025364336,0.02122116,-0.006845716,0.047664974,-0.010327159,-0.031922653,0.029154768,0.03983416,0.015235859,0.027993869,0.023371333,0.0062571857,0.028071743,-0.012102956,-0.03596349,-0.02060588,0.05128167,-0.081489824,0.015021809,0.040095117,-0.04290352,-0.014151751,-0.003756504,-0.084155425,-0.024207052,0.03798456,-0.0053000594,0.003434792,-0.063246846,-0.018685788,0.08570312,-0.04460871,-0.080400646,-0.0023683715,-0.0052275155,-0.05567738,0.022975944,-0.07181577,0.016480513,-0.0037992676,0.050171994,-0.024311753,0.0059669116,-0.017186664,0.00034539506,0.079495914,0.02780961,-0.094329976,-0.07060336,-0.097444974,0.07193491,0.050534904,-0.03854116,-0.00532447,-0.11689928,0.038360115,-0.035770558,0.13751629,-0.10358317 +4.2.1.24,"The enzyme catalyses the asymmetric condensation and cyclization of two 5-aminolevulinate molecules, which is the first common step in the biosynthesis of tetrapyrrole pigments such as porphyrin, chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430. The enzyme is widespread, being essential in organisms that carry out respiration, photosynthesis, or methanogenesis. The enzymes from most organisms utilize metal ions (Zn2+, Mg2+, K+, and Na+) as cofactors that reside at multiple sites, including the active site and allosteric sites. Enzymes from archaea, yeast, and metazoa (including human) contain Zn2+ at the active site. In humans, the enzyme is a primary target for the environmental toxin Pb. The enzymes from some organisms utilize a dynamic equilibrium between architecturally distinct multimeric assemblies as a means for allosteric regulation.",384,0.99999994,-0.05480124,-0.05311278,-0.11248742,0.0017006862,0.13827324,0.03704846,0.00853384,0.026083708,0.022520324,0.0016674653,-0.031915396,-0.01776801,-0.018896557,0.051659517,-0.06587802,0.04139175,-0.08677591,0.013896774,0.025131896,-0.024639754,0.052741226,0.07413127,-0.0015028942,-0.023361892,-0.052233577,-0.018960495,-0.0044992436,-0.021433536,0.02519033,-0.03336484,-0.0066402624,-0.020321578,-0.030639382,-0.07641619,0.081350446,0.06048033,-0.04081886,-0.03458763,0.015084212,-0.028628545,0.052175887,0.04246051,-0.015418669,-0.017201975,0.0036764485,-0.023432361,0.08574988,-0.050403792,0.00058950053,-0.03676688,-0.04246459,-0.044015735,-0.045615714,0.049552325,-0.009130791,0.05543056,-0.04423198,-0.04338566,-0.016952993,-0.055224832,0.015046247,-0.043231145,0.017888457,-0.002043078,0.111034796,0.012783778,-0.026033735,-0.05877782,0.011899954,-0.06212376,-0.0904841,-0.017893288,2.5400273e-05,0.0244568,-0.005112024,0.067720376,0.028250609,-0.06411837,0.009607008,-0.03022066,0.056623187,0.017909104,0.08977644,0.082275845,0.11962666,-0.07112538,-0.0276188,0.028538853,-0.0020792065,0.077896774,0.102749065,0.06298875,0.0860582,0.012149212,-0.072755784,0.039585683,0.029293688,0.030180577,0.06282566,-0.01925838,-0.01523166,0.02045135,-0.0019037692,-0.045951497,0.016431049,0.02396481,0.025906157,0.10485074,0.051509555,0.052810047,-0.011343574,-0.0025541487,0.03135015,-0.020784242,0.065790705,0.0756895,0.0637098,-0.036848113,-0.008050951,-0.037914734,-0.01876202,0.008557594,0.053273607,0.059161887,-0.020653306,0.05105267,-0.13119486,3.928182e-33,0.05204765,0.055086322,0.023511337,0.0052553248,-0.007417787,-0.018553944,-0.049364656,-0.023404453,-0.032522958,-0.0016398762,-0.07880046,-0.06209542,0.04029591,0.02169278,-0.033585094,-0.07049778,0.009187469,-0.02696337,-0.001276043,0.063249744,0.01852367,0.010591997,-0.06069329,0.047465768,0.041302484,0.057773303,-0.045958564,0.03079779,-0.08254195,-0.024362229,0.007702407,-0.108599916,-0.11291637,0.013862786,0.14596511,-0.023027278,-0.003285909,0.03669138,-0.041269425,-0.019686691,-0.051403463,-0.030836662,-0.057545092,-0.025612747,0.08105109,-0.036111716,-0.09495437,0.117376514,-0.010138616,0.007505527,0.014403438,-0.008210909,0.035509802,0.028433584,-0.11744699,0.027065355,-0.03645844,-0.021379342,0.054970734,0.041958466,0.022620995,-0.000560131,-0.045358103,0.09884043,0.017869867,-0.00357206,-0.022738013,-0.07826716,0.009270421,0.09441494,-0.058416676,-0.005386802,0.06843967,0.03185559,0.023238936,-0.026362818,0.013548693,-0.019050112,0.026969405,0.038062565,-0.02128357,-0.045259632,-0.022781314,-0.032439675,-0.08398805,-0.042280294,-0.0054092747,-0.059088387,-0.00862978,0.010283136,0.06033083,-0.08945319,-0.012877552,0.0012831875,-0.07796905,-4.28384e-33,0.11287479,-0.06720673,0.067448646,-0.15321618,-0.09760525,0.045249537,0.020342167,-0.10495303,0.019453535,-0.012830842,0.06581854,0.0041889315,0.052483365,-0.001223949,-0.0027467548,0.031675678,-0.020372616,0.13519621,0.0644597,-0.057379786,0.0014883194,0.06947639,-0.015904125,0.0012417812,0.018901218,0.058777045,-0.00013603907,0.03631822,0.058347907,0.07867777,-0.06897916,0.08523495,-0.008602429,-0.06950437,-0.06569626,0.042136807,-0.10502698,-0.05499734,0.017154848,0.053060364,0.053480882,-0.005931095,-0.0213427,0.044626415,0.040466823,0.0663054,-0.09644629,-0.011453848,-0.042700224,-0.031445112,0.05793766,0.049317505,-0.041195597,0.010445632,0.03829686,0.06006165,0.05268022,0.0028954071,0.031785455,0.018221734,0.033420157,-0.032723606,0.004713106,0.009212251,0.00079003396,-0.0045505622,0.06110694,0.077943146,-0.004327488,-0.008999577,0.01929334,0.048847448,0.05002083,0.02456314,-0.05612797,0.0062277694,-0.04130567,0.0038007589,0.0116019,-0.0354623,-0.025824912,0.023362566,0.0309528,-0.045035854,-0.0026634217,-0.08527741,0.030413195,0.1111324,0.0290896,-0.031873167,-0.06759373,-0.03147638,-0.056708053,0.036583178,-0.016320601,-5.1083745e-08,-0.019068742,-0.016997613,0.06409031,-0.06408362,-0.02700598,0.06383862,0.059705794,-0.052353047,0.034043316,-0.009401869,-0.032259215,0.05085555,0.007507193,-0.02440868,0.007560885,0.08200982,-0.07514393,-0.022953654,-0.03810131,-0.0052936254,-0.0572683,0.0008139665,-0.11028165,0.041345514,0.026067812,-0.07842109,-0.0037368585,0.11865555,0.018743977,-0.045252997,0.0008157704,0.021048073,0.04754376,-0.05262052,-0.07352613,0.05040648,-0.029745689,-0.11739642,-0.047805183,0.013815928,-0.11743938,-0.042129453,-0.036284287,-0.010107491,-0.019569267,-0.020346355,-0.032949317,0.046796035,0.015820108,-0.005904309,0.022064978,-0.037331656,-0.033860754,-0.026189508,-0.08775493,0.047393247,0.03861132,-0.0017726164,-0.020350495,-0.04561111,0.02421683,-0.012036844,0.107341476,-0.09672083 +4.2.1.27,"The reaction is effectively irreversible, favouring oxopropanoate (malonic semialdehyde) and its tautomers. Also acts on but-3-ynoate forming acetoacetate. The mechanism appears to involve hydration of the acetylene to 3-hydroxypropenoate, which will spontaneously tautomerize to 3-oxopropanoate. It is thus analogous to EC 4.1.1.78, acetylenedicarboxylate decarboxylase, in its mechanism.",384,0.99999994,-0.051064335,-0.00011752584,-0.03712496,0.030756054,0.017501224,0.037926212,-0.05015449,-0.03257877,-0.022841705,-0.013549226,-0.016541827,-0.03426413,-0.09942512,-0.06734557,-0.05493216,0.03740434,-0.055457972,-0.023832342,0.049877714,0.04401889,0.03629702,-0.043671526,0.002024605,-0.0099763805,0.0862902,0.047577452,0.09166918,0.023986097,-0.03598294,-0.12898898,0.033901487,-0.00434986,-0.041420434,0.019007282,-0.0076990263,0.047198292,-0.043991674,-0.048970684,0.035811808,0.06893072,0.0142210685,-0.009507677,-0.015900198,-0.026519043,0.008577846,0.010161448,-0.07177912,0.039924935,0.006595958,-0.029545646,0.05337468,-0.022360425,-0.012994972,-0.016248994,-0.046955157,-0.032267373,0.009896206,0.04705454,-0.030533208,0.034737747,0.060737856,0.010846158,-0.036549333,-0.029115366,0.012849169,-0.053338006,0.024288375,-0.0798954,0.065560766,0.01905609,-0.00010815076,-0.08074863,-0.019833837,0.03630485,0.06653982,0.008322542,-0.02135651,-0.036672037,0.048516344,0.04350046,0.06950838,0.030683516,0.028679797,0.07750615,0.02760865,-0.0058916034,-0.0020766228,-0.06802988,0.017717382,0.058821928,-0.03484845,-0.014779117,-0.032135565,0.007093095,0.00032586526,0.032456297,0.056560196,0.05626943,-0.0018119285,0.009359992,-0.0021855203,0.0700462,-0.026093148,-0.11009666,0.011692089,0.008659275,0.019622024,0.059760667,0.029274223,0.012735073,-0.06341418,-0.08885611,0.042964686,-0.041641157,-0.06421735,0.11909278,-0.039032385,-0.05615763,-0.010466932,-0.06488416,0.041805882,-0.029928187,0.014853341,-0.017655436,-0.067778654,0.036027633,-0.077236116,4.504105e-33,0.040735453,0.0154811,-0.024962293,-0.0072814412,0.012670557,-0.01849758,-0.100420855,0.024662944,-0.046691537,-0.014552729,-0.02990595,-0.052690364,0.0668216,0.026247324,-0.097662315,-0.08331257,-0.063592434,0.043896474,-0.0014426466,-0.03873688,0.017880619,0.057604052,-0.03828093,0.059949283,-0.07622586,-0.019006822,0.00027405776,0.016136907,0.06511102,-0.009990128,0.027034158,-0.021150427,-0.042615347,-0.037686065,-0.008591122,0.0029668892,-0.012503959,-0.07490886,0.020291114,0.0930495,0.03812891,0.04360662,0.009015072,-0.063519925,-0.006029641,-0.03184049,0.018584011,0.07969489,0.024966242,-0.026181642,0.058269814,0.0032617569,0.07130669,0.052472133,0.0037826148,0.0064847725,-0.03468185,-0.01849579,0.08507944,-0.050833795,0.035437025,-0.0063791024,-0.00093117595,-0.032819983,-0.036989298,0.06771779,-0.04262343,-0.006703223,-0.04775761,-0.020461319,-0.035150375,-0.048410617,0.046504915,-0.03283014,0.024992302,-0.048475042,-0.024697231,0.031709265,0.07772178,-0.03533392,-0.0035517772,0.028687231,0.006405483,-0.00033635742,-0.015203407,-0.033006947,-0.029980332,-0.006535965,0.034592304,0.099175885,0.038531423,-0.058786508,-0.027547838,0.0021554846,0.019706536,-5.5253157e-33,0.08278681,-0.094287336,-0.07303191,-0.023331728,-0.006056926,0.06909432,-0.04338732,0.04652468,-0.01039775,-0.029621877,0.107880235,-0.024582585,0.08107463,-0.0551695,0.05457519,-0.00749461,-0.0057150763,0.032255962,-0.009536756,0.001329262,0.099752694,0.010795992,-0.046037085,0.044557713,-0.020460093,-0.016187547,-0.03402648,0.009312376,0.10714679,0.084422074,-0.029423367,-0.07475332,-0.026850725,-0.002174681,-0.05545262,0.10167614,-0.05694314,0.03809535,-0.06695221,0.008560372,-0.019847328,-0.0061027254,-0.019458566,0.09613524,0.13929662,0.013882342,-0.0809025,0.0056738504,0.038757563,-0.02348506,0.03729374,0.0031711257,-0.059449233,0.019920876,-0.029304173,0.09585832,-0.044822194,-0.015814785,0.015283497,0.067412235,-0.05624127,-0.058633,0.067301996,-0.08083702,0.060073663,0.09699572,-0.04939178,0.074842796,0.09669484,-0.07979945,0.09929683,0.05467902,-0.028793737,0.028306277,0.09711896,-0.1350261,-0.05981738,-0.012202895,-0.060873043,-0.03939365,-0.02348753,-0.004194925,0.034712426,-0.031974606,-0.044849377,-0.043007568,0.011735058,0.119031794,-0.10051263,0.035794612,0.02335295,-0.03729054,-0.0384974,0.119805306,0.049844082,-4.404536e-08,-0.03521699,0.041319005,0.14624354,0.02707101,-0.0210425,0.022387438,0.108895935,0.032479532,0.016952978,-0.13316643,-0.0053462787,0.089774445,0.034422487,0.026337527,0.056773003,0.01911072,-0.093139626,0.111422494,-0.0724671,-0.023869207,-0.05962912,-0.038726185,-0.02675494,0.01748729,-0.026266582,0.02651465,0.05962731,0.10851488,-0.042138718,-0.024624456,-0.052976206,0.062341873,0.00679581,-0.055142764,-0.10778212,-0.005165493,-0.06113399,-0.043523096,-0.0022796153,-0.05248011,-0.028204916,-0.00022273751,-0.10068053,0.05150291,-0.0020083343,0.0012357732,0.038241196,-0.0037410895,-0.054760914,0.016847469,0.059068166,-0.0023694162,-0.01602806,0.027242731,-0.010992093,0.0057567083,-0.072024025,-0.041622087,0.053332586,-0.025820876,-0.025460385,-0.020000024,0.1578274,0.027753968 +4.2.1.28,"Two different forms of the enzyme have been described. One form requires a cobamide cofactor, while the other is a glycyl radical enzyme. The cobamide-dependent enzyme has been shown to also dehydrate ethylene glycol to acetaldehyde.",384,0.99999994,0.0034273684,-0.069474764,-0.13769181,-0.04767118,0.03554146,-0.004497704,-0.1173646,0.008420585,0.0026829976,-0.012246279,0.05528841,-0.0141836805,-0.08677004,0.008062907,-0.045315992,0.010529257,0.003759299,-0.075677864,-0.0055015893,-0.025740745,0.046139874,-0.05379125,-0.053568553,-0.011937259,0.075055204,-0.012554522,0.070598885,0.028403543,-0.023284145,-0.08379889,0.1026937,0.012197879,-0.07184683,-0.009852367,0.031306177,0.03096481,-0.0737649,-0.017639896,0.03228618,0.012830486,0.011430987,0.009959938,-0.0732048,-0.007829724,-0.04226143,-0.03806939,0.0028851687,0.048122644,-0.018950202,0.02247795,0.004252512,-0.054841787,-0.042761754,-0.039983697,0.016808731,0.003789278,-0.07079533,0.033926312,0.045439478,0.0469866,0.0049994765,0.02396068,-0.016195819,0.02798421,-0.027829174,-0.057478826,0.07868907,-0.09513045,-0.010330163,0.001995881,-0.062372234,-0.08215666,0.0071071857,-0.031225974,-0.03737509,-0.024217032,-0.091997705,-0.0013504785,0.08572267,-0.019435007,0.022117205,0.018004728,0.08337338,0.06159762,0.04751295,0.05735214,0.040118698,0.011657276,0.027780905,-0.06413824,0.030180244,0.011602931,0.00329495,-0.022449601,-0.04229063,0.021856064,0.059500523,0.06857786,-0.027632616,-0.08557522,-0.00869043,0.05524364,0.00877848,-0.026560899,-0.08016573,0.021204907,0.068196185,0.081674784,0.060458712,0.024374036,-0.080429114,0.07353014,0.029752567,-0.033654545,-0.031968936,0.07618686,0.052392706,-0.040203635,-0.009672321,-0.01222131,0.11505176,-0.026923843,0.099256575,0.0066256477,-0.009439345,0.089790024,-0.06087282,6.0845e-33,0.08891444,0.05487787,0.0042360094,-0.05000025,0.035546202,-0.048177946,-0.09619682,0.030462243,-0.05415297,-0.022629239,-0.011807782,-0.029783169,0.040582735,0.026848886,-0.03850013,0.030708758,-0.026546353,-0.04437525,0.025149442,0.002391034,0.040465906,0.06975685,-0.027604764,0.056211997,0.06495277,-0.013464303,0.03606757,0.07250508,0.006875543,-0.0042370395,-0.013316424,-0.10890498,-0.09037735,0.006718901,0.044892114,0.031842366,-0.06498623,-0.029804844,0.0320683,0.0015269833,0.037367724,-0.018936303,0.09160094,-0.06476371,0.022354174,-0.013135989,-0.057772063,0.06194768,0.01152801,0.059953243,0.044111688,0.0072452817,0.10019315,0.011559085,-0.040011328,0.07501838,0.018446662,0.049997393,0.042369917,0.02282476,-0.040685777,0.04416003,-0.023923801,0.013687827,-0.03367115,0.038284417,-0.09255576,-0.029504677,0.010721677,-0.00071300025,-0.049600333,-0.004519437,0.0935366,0.044879593,0.025679393,-0.03141667,-0.034946658,0.0015096101,-2.0622936e-05,-0.07778664,-0.048811845,-0.027837453,0.011057834,-0.049961627,-0.031556625,-0.022954755,-0.1068718,0.013855174,-0.051000696,0.010709733,0.028671643,-0.034821466,-0.0052311523,-0.010675386,0.01904738,-6.836421e-33,0.05542951,-0.054292362,0.059877552,-0.0584157,-0.0116203595,0.08799251,0.06820178,-0.13171032,0.053141434,-0.035548903,0.04635034,0.03472933,-0.020878892,-0.01325649,0.04474052,0.056957114,-0.043205567,0.05289804,0.0016720722,-0.06639794,-0.00989713,0.057731688,0.009985561,-0.08307724,0.060322907,0.050739355,0.077510454,0.027679065,0.066933095,-0.008652962,-0.008887696,-0.0067547048,0.014812905,-0.07340653,-0.050947715,0.034207802,-0.06703402,-0.03594809,-0.058065787,-0.03917626,-0.04779868,0.031599566,0.06304738,0.08129947,0.0897653,0.027140306,-0.10361064,-0.065028206,0.021916967,-0.042819362,-0.009154308,0.02514324,-0.0607976,0.05739529,0.009748869,0.09250782,0.108168446,-0.033824272,-0.04147941,-0.0191117,-0.041181326,0.00563942,0.065396704,-0.0030910035,0.0136201605,0.006134608,-0.0138593605,0.060085543,0.027432812,0.004143049,0.02825827,-0.021652168,-0.020333428,0.086475715,-0.009857715,0.017403074,-0.054454032,0.04510131,-0.013107539,-0.03564336,0.013082453,-0.023449365,-0.018381428,0.01352269,-0.069020644,-0.068728775,-0.006022229,0.03567507,0.033505145,0.01538837,-0.0024437984,-0.027289525,-0.028414542,0.08954934,0.09465041,-4.036593e-08,0.00991743,-0.0628443,0.046654858,-0.12562245,0.023761524,0.036817063,0.03538725,-0.036072478,0.0037586389,-0.050333522,-0.056018703,0.10050815,-0.0069248336,0.07269534,-0.043836474,0.030459268,-0.047170237,-0.06124904,-0.020508422,-0.015131062,-0.071600385,-0.02307532,-0.09249161,0.095660575,-0.02754474,-0.008662177,-0.032765213,0.093498625,-0.048540372,0.053861298,-0.040625736,0.13444616,0.015506753,-0.075598404,-0.11991909,0.0006625949,-5.503032e-07,0.030421864,-0.052347317,0.038571216,0.035603102,-0.054367788,-0.06262121,0.008356334,0.08197011,0.008215746,0.05567577,-0.052682146,-0.015139344,-0.006023035,0.013337512,-0.0075855376,-0.030889906,-0.033137403,-0.07460768,-0.019644106,-0.081369825,-0.062028795,0.050004795,-0.09865139,0.010035581,-0.009998735,0.18520296,0.01322863 +4.2.1.30,"Two different forms of the enzyme have been described. One form requires a cobamide cofactor, while the other is a glycyl radical enzyme.",384,1.0,-0.010453123,-0.08783013,-0.15660545,-0.027912688,-0.018900115,-0.011589409,-0.1374033,0.039956067,0.013876557,-0.03166109,0.08902961,8.095811e-05,-0.050541636,0.049469527,-0.014305028,0.02144106,-0.0026821273,-0.102950945,-0.009633355,-0.0043941606,0.06543735,-0.021271154,-0.038304128,0.008180228,0.034617405,-0.0020278625,0.07112143,-0.007677187,0.038219456,-0.050733447,0.08815126,0.048572965,-0.022968521,-0.0051759477,0.019522857,0.049058996,-0.0942858,-0.015902363,0.038956515,0.00639103,0.025634147,0.0042661,-0.03764889,0.014066775,-0.052826095,0.0017379647,0.010978567,0.03159721,-0.0029037644,0.022620164,-0.03317507,-0.065511055,-0.08141316,-0.0066350247,0.018597586,0.05082457,-0.09824248,0.037833735,0.07205857,0.053207453,-0.032865793,0.032651264,0.008456054,0.02832518,0.00011817773,-0.028607894,0.045990646,-0.11233946,-0.036677007,-0.005813156,-0.03367611,-0.08220425,-0.001559485,-0.038031608,-0.055585656,-0.028846385,-0.06793229,-0.0036495994,0.03214827,0.0033220751,0.019106679,-0.008243618,0.04045693,0.04572197,0.044953216,0.074227214,0.02977668,0.016574522,0.042015545,-0.05451425,0.045867383,-0.002429642,0.032850426,-0.0091776475,-0.02544449,0.0006713847,0.03372088,0.10063779,-0.046852596,-0.08428873,-0.017460622,0.023861716,-0.0034016815,-0.018901573,-0.11042965,0.021057568,0.029241474,0.0693149,0.045978647,0.029921371,-0.059208002,0.10460635,0.053767852,-0.052665547,-0.021137338,0.09498053,0.062840305,-0.010841347,0.014960514,0.044354748,0.11617911,-0.047128394,0.089176856,-0.0046159443,-0.027558498,0.059716832,-0.07154653,1.6629313e-33,0.09985437,0.084602796,0.0137557415,-0.06565496,-0.022703119,-0.026906814,-0.078443296,-0.0017308558,-0.04386642,-0.047660306,-0.0055399053,-0.012306497,0.039687015,0.02662742,-0.049622696,0.009086332,-0.016295923,-0.03091213,0.0057529854,-0.0029144492,0.04861495,0.10060304,-0.020459725,0.07247627,0.049725123,-0.003563269,0.069047436,0.058205273,-0.0059916913,0.0043718982,-0.022498406,-0.08945579,-0.09292873,0.038397983,0.04100548,0.05320291,-0.062160857,-0.078208186,0.0029234933,-0.01797159,-0.022182088,-0.020370232,0.048632998,-0.034819882,0.082727514,-0.053251524,-0.06943002,0.0610796,0.021048978,0.07277611,0.03295022,0.0034955468,0.06998491,0.022860922,-0.019442644,0.044649236,0.037770256,0.06304867,0.033693045,0.020853397,-0.0127683515,0.034964986,-0.027217468,0.029370615,-0.03853647,0.058201514,-0.1195033,-0.042610664,-0.017396359,0.04253623,0.004376381,0.01571694,0.06628334,0.07809616,0.031147065,-0.06387604,-0.024606453,0.016022751,0.004253925,-0.04041662,-0.0671721,-0.039501198,-0.01157875,-0.02229726,-0.06749616,0.012967599,-0.0660599,0.0035306835,-0.07523451,0.012526767,0.052146908,-0.024655947,0.0038295672,0.020041626,0.021548782,-2.7169282e-33,0.03398166,-0.048830513,0.052246787,-0.03006179,-0.016936999,0.058043428,0.09225045,-0.16551547,0.05525682,-0.049735773,0.037877623,0.028830806,-0.060441155,-0.0240684,0.03013547,0.031022713,-0.030087208,0.036520813,-0.013631874,-0.0533258,-0.008895531,0.06256479,-0.0119279055,-0.068997,0.042355787,0.04861613,0.05559705,0.062670484,0.056912877,0.03709695,-0.031332154,0.0038531478,-0.0021105353,-0.07777641,-0.051050935,0.04947709,-0.080487676,-0.036472887,-0.0385314,-0.102671705,-0.058533307,0.03654014,0.09008938,0.092270136,0.05635509,0.037649315,-0.063795246,-0.0307442,0.055429004,-0.05302337,-0.047265705,0.04757533,-0.04699381,0.032752234,-0.017825268,0.061606154,0.06251504,-0.04190096,-0.04433487,-0.04842694,-0.03102758,-0.005036767,0.065524645,-0.0042381263,0.013190031,-0.005536798,0.019386118,0.034292098,0.019169632,0.010821797,0.011182226,0.0023684383,0.003602424,0.0628764,-0.023987796,0.028704414,-0.075345546,0.03731217,-0.013210999,-0.024529196,0.012745096,-0.014160834,-0.025180696,0.005874901,-0.055625416,-0.049552727,0.0056386194,0.020993778,0.049982667,-0.0024916658,-0.03850195,-0.0029294193,-0.010302399,0.04513336,0.10318218,-3.03607e-08,0.03055104,-0.051205397,0.036441512,-0.14664745,0.06437509,0.07887534,-0.02668577,-0.05429062,0.017130962,-0.02406516,-0.064534,0.09053934,-0.024075195,0.061176464,-0.026364407,0.025717298,-0.061771177,-0.07316725,0.005344453,-0.016787663,-0.07316003,-0.036596972,-0.074908234,0.07438155,-0.065013796,-0.0054129185,-0.022789046,0.13099685,-0.07034329,0.048591424,-0.033664383,0.09573348,0.043467224,-0.060701203,-0.12088645,0.030495513,0.016492449,0.041319575,-0.027077515,0.06821954,0.029338026,-0.05398986,-0.030249676,0.029928867,0.05992021,0.0006877787,0.05882978,-0.07381403,-0.013672086,-0.006699306,0.0032536746,-0.035835095,-0.04213007,-0.0290461,-0.0511125,-0.02132523,-0.06113921,-0.06296998,0.031981282,-0.082607634,-0.007320147,0.011659012,0.16653804,0.022929335 +4.2.1.32,"The enzyme exists in an inactive low-molecular-mass form, which is converted into active enzyme in the presence of Fe2+ and thiol. cf. EC 4.2.1.81 D(-)-tartrate dehydratase.",384,0.99999994,-0.011207098,-0.0080759125,-0.08686571,0.023551034,0.08200365,-0.048394855,-0.0192119,0.06231188,-0.017424522,-0.03518327,-0.008175688,-0.034232695,-0.0886773,-0.00048525163,-0.0067376075,-0.025170995,-0.06186773,-0.027336314,0.026221905,0.006353575,0.08347246,0.0036604276,-0.033752434,-0.009756629,0.013020236,0.0054234043,0.06541815,0.0050099767,-0.0597182,-0.08354209,-0.07619089,-0.029643457,0.06113149,-0.036482282,0.060552914,0.0783652,-0.06682361,0.0019086549,-0.022194594,-0.022953313,0.06806513,-0.042696033,-0.049166862,-0.025530057,-0.063808545,-0.06824466,0.010854644,0.036313996,-0.0041692313,0.037926435,-0.047003474,-0.043659605,-0.012780447,0.097626194,-0.016655186,-0.050267097,0.017201249,0.012251736,-0.054869037,-0.040316645,0.05721668,0.0030418925,-0.007520031,-0.01948703,0.08091627,-0.012408339,0.07203668,-0.056048077,0.026660874,-0.05709473,-0.022078918,-0.02035089,-0.023089292,0.040243216,-0.01104138,-0.046308953,-0.027743705,0.04388939,0.08434323,0.033152644,0.03691777,-0.00026794287,0.029123515,0.041233975,0.0034370557,0.03269567,-0.032962617,0.018364394,0.02920804,-0.0016396024,-0.003355396,0.039218046,-0.08847172,9.407221e-05,-0.029136673,0.014766277,0.03738771,0.07223662,0.04038018,-0.036546245,0.020803394,0.11589264,-0.074600704,-0.06124163,0.0055415747,0.037681803,0.013972521,0.04383738,-0.0018586968,0.046041276,0.03486762,0.0069069285,0.085844666,0.07963304,-0.0044549657,0.08000217,0.010325217,-0.04449246,-0.08763803,-0.0266057,0.07763465,0.057316,0.082405,0.06343008,-0.024918675,0.08140165,-0.14158379,-2.1673175e-33,0.054264523,-0.007888485,0.069814324,0.023558015,-0.010159901,-0.013389157,-0.059439808,0.057165116,-0.02871787,0.04464144,-0.11458486,-0.08556558,0.06953201,-0.014899439,-0.07043847,-0.08723611,0.06917544,-0.007661001,0.05799386,0.025418786,0.041442346,0.1357009,-0.03880333,-0.014549038,-0.039345298,0.12675372,-0.019402253,0.039282843,0.04249599,-0.0065543763,0.015170636,-0.17839126,-0.06099821,0.00024384662,0.08146241,-0.02389257,-0.07330417,-0.00015708386,-0.020497402,0.036851153,0.039825965,0.03887833,0.06738627,-0.089545816,0.0067527704,-0.04113045,0.050250873,0.050669752,-0.0038188344,0.0448143,0.014175658,-0.014172663,0.05169479,-0.09114616,-0.09254069,0.014767469,-0.006692651,0.01987641,0.0033131803,0.04853972,0.029921087,0.08303905,-0.051818974,0.06618394,-0.02386883,-0.0084230015,-0.09075008,-0.03927971,-0.020007867,0.06962661,-0.029251268,0.007312599,0.056714684,0.008247776,0.07788393,-0.034705147,-0.04565459,-0.059671674,0.027856007,0.0023657847,-0.01197965,-0.011717364,-0.033325497,-0.04951241,-0.030243732,-0.006697236,-0.030134255,-0.06547931,-0.031651955,0.034481354,-0.023603251,-0.02292433,-0.11878958,-0.0395324,0.07811799,1.9932412e-34,0.08319527,-0.059239116,0.010842632,-0.07518598,-0.054497015,0.09420873,0.03752179,-0.059063893,0.04144812,-0.0016389675,0.0681115,-0.02213002,-0.004681093,-0.08157377,0.03102046,0.09650593,-0.06898629,0.01685002,0.017625367,-0.025060639,-0.018453961,0.10535441,-0.020486254,0.039138347,0.009340461,-0.037537992,0.046289533,0.07118508,0.069668785,0.0013903975,0.015813798,-0.043462895,0.01664619,-0.011840512,-0.09409428,0.03642699,-0.032806464,-0.027336998,0.033084206,0.057133477,-0.036487382,0.014098477,0.019897742,0.03901162,0.0327846,0.065878615,-0.08229581,0.016209153,-0.014795843,-0.031154146,0.054545768,-0.06306613,-0.02333406,0.029360553,0.042311862,0.04623251,0.0013145923,0.066534586,-0.06893327,0.022504942,0.019428292,-0.07361382,0.04542228,-0.013630759,-0.013122712,0.024931397,-0.06328977,0.068296246,-0.023085985,0.019710427,0.076970786,-0.0008264239,-0.02707544,0.0407198,-0.020383986,-0.045707997,-0.024563588,0.01809793,0.03604814,-0.09825349,0.00020677637,0.039902523,-0.020155659,-0.08314478,-0.004712479,-0.06729159,0.036315423,0.0818896,-0.030631412,0.071985506,-0.055336118,-0.0124455495,-0.046632662,0.07902883,0.055771776,-3.2194848e-08,-0.012323945,-0.052082207,0.028715294,-0.03351019,0.020294013,0.025416283,0.046411864,-0.02604825,0.018757302,-0.011044904,-0.056834485,0.052899342,0.027417831,-0.03214597,0.064073645,0.045422204,0.033589296,0.04096309,-0.055107854,-0.009470345,0.003364178,-0.02931995,-0.1748509,0.026908737,0.060462367,-0.03802777,-0.019843664,-0.039561395,-0.010374431,-0.033248935,0.010944612,0.09892152,0.017200964,-0.04168494,-0.05246429,0.01872559,-0.04754145,-0.010126379,-0.019745031,0.040632587,-0.011970876,-0.009169012,-0.08676642,-0.049502295,-0.026586266,0.02436194,-0.04760696,0.055523112,-0.027614307,0.02440749,0.072315276,-0.011743906,0.020624982,-0.0293817,-0.07365843,0.0786818,0.0061579035,-0.048434958,-0.012517302,-0.073288016,0.10078053,0.012401981,0.1659384,-0.047440834 +4.2.1.33,Forms part of the leucine biosynthesis pathway. The enzyme brings about the interconversion of the two isomers of isopropylmalate. It contains an iron-sulfur cluster.,384,1.0,-0.028846754,-0.03422826,-0.10030544,0.019993672,0.08667013,0.04239523,-0.07601785,0.029787285,0.030214231,-0.098226115,0.052412864,-0.033217948,-0.020605018,-0.061684307,-0.015664516,0.0007934807,-0.10843296,0.043457877,-0.057021853,-0.08989669,0.070618995,0.014037659,-0.015942698,0.0149721615,0.05146343,0.048909493,0.04189924,-0.0028058968,0.025691662,-0.014628644,0.016286494,-0.10980943,0.00696514,-0.057040296,0.060024824,0.029190658,-0.027841471,0.016973045,0.01599151,-0.0029250656,0.016614443,-0.03228084,-0.05694164,-0.031525575,-0.04743679,-0.04681753,-0.04872845,-0.0099261,-0.02468374,0.032373246,-0.02335676,-0.06004686,-0.086510636,0.060427696,0.030273883,0.0077257818,0.0046086344,-0.021449804,0.02106968,0.011939381,0.02726686,-0.013133319,-0.056831755,-0.01987732,0.010790948,-0.02005875,0.06128844,-0.027389394,0.03445507,-0.09313802,-0.025049916,-0.070759706,-0.07656819,0.0697033,0.003931053,0.013913388,-0.018165283,0.0036995136,0.04531335,-0.008675131,0.0009378596,0.028582815,0.020300185,0.08913681,0.005579667,-0.024625607,0.02744842,-0.038913924,0.015892355,0.0031774188,0.005357179,-0.056560457,-0.057636697,-0.035964157,0.04988988,0.057917956,0.021922372,0.062173348,0.077949084,-0.01734073,-0.0123439245,-0.002467571,-0.0863788,-0.07400263,-0.0797569,0.0026795832,-0.009336954,0.09511791,-0.007433472,0.030663533,-0.004018545,-0.025319878,0.027056849,0.044910498,-0.0029798606,0.07638546,0.07865327,-0.0003100042,-0.03533017,-0.01781987,0.010141526,0.032203127,0.07048253,0.11170244,-0.012093781,-0.041506153,-0.1195124,-1.1155684e-33,0.10112905,0.041826416,0.006936021,0.011224546,-0.0721597,0.013645811,-0.06377646,0.06775342,-0.029038215,0.001077315,-0.10173016,-0.10434355,0.013408105,-0.012310142,-0.069088444,-0.060228404,-0.005460036,0.0020831025,0.048628516,-0.03260343,-0.0025551757,0.117607966,0.010666936,-0.015922463,-0.0073485877,0.005796596,-0.04382516,-0.003917663,0.00022909726,0.010486292,0.026844516,-0.10751959,-0.07378378,0.014261378,0.097156025,0.01706905,0.011020294,-0.030173674,-0.050588474,0.06523269,0.042266298,-0.0017022624,-0.0025356426,-0.091375776,0.09425743,0.021831147,-0.040314887,0.08688952,0.036627978,0.02420241,-0.031014876,0.005093041,0.11004476,-0.027980987,-0.1104802,0.036986496,-0.035221353,-0.04219053,0.007841548,0.045360457,0.02927684,0.08832281,0.004653851,0.062090777,0.027226463,0.007774348,-0.13648055,0.031483687,-0.00025894644,0.08287934,-0.06263056,-0.002443212,0.023677394,0.031602405,0.055371102,-0.04392416,-0.14862187,0.043193985,0.007117696,0.009070822,-0.05254622,0.012732757,-0.05818907,-0.044372737,-0.032794748,-0.017140217,-0.056835767,-0.07820213,-0.01070665,0.0078933565,-0.0060520996,-0.0032523277,-0.047952596,0.050971832,0.054823987,-1.804272e-33,0.05041069,-0.14321962,0.089436464,-0.07113402,-0.027967295,0.054696344,-0.0014767599,0.0026699954,0.04266043,0.11332757,0.049330827,-0.020163404,-0.016664952,-0.1144588,0.0040458846,0.004451088,0.023074947,0.09751691,0.09740498,0.055730496,-0.039966106,0.03544948,-0.012031462,0.011823988,0.048011143,-0.015084132,0.053110216,0.054681983,0.11043058,0.08667281,-0.019768775,0.020754447,-0.022070317,-0.08022644,-0.072333194,0.05873999,-0.062899776,0.028706718,-0.0019353824,-0.078763,-0.05138637,-0.03299626,-0.00089571456,0.08964429,0.10583855,-0.0048776637,-0.027520724,0.060551066,-0.01999079,-0.05230438,0.045419488,-0.050556194,-0.010456855,0.06893501,0.029739462,0.057798866,-0.061210807,0.07929358,0.025060546,-0.04029776,-0.011443376,-0.036760956,-0.007816089,-0.039950587,0.082775585,0.0058704787,-0.036460403,-0.00056931557,0.019743184,-0.0037133025,0.09175206,-0.0293727,0.008322016,-0.010024843,0.024745693,-0.06115769,-0.04363197,-0.04348302,-0.07708728,0.015517457,-0.030462049,-0.005285237,-0.015013588,-0.09731223,-0.022365758,-0.030644007,0.020990988,0.110565886,-0.0034198912,-0.016734907,-0.04170079,0.032267056,-0.021171419,0.08627469,0.0041786246,-2.9834965e-08,0.024264988,-0.044292223,0.042483084,-0.010446665,-0.026826188,-0.0006965524,0.030316817,0.011449512,-0.024954988,0.062626846,-0.036061015,0.08740369,0.0063867783,-0.04421423,0.052910797,0.042408824,-0.03191804,0.092489645,0.0020999776,0.023547087,-0.036206063,-0.05209732,-0.019549811,0.025642097,0.011307009,-0.12864321,0.04415814,0.02807069,0.016272314,-0.051992502,0.039101068,0.0043162485,0.014529718,-0.04097355,-0.04918674,0.063790046,-0.048206303,-0.042782724,0.07688638,0.0041331844,0.023655681,-0.013802547,-0.031780586,0.027772384,0.06619908,0.00822757,0.008270419,0.054086737,-0.067371555,0.007270188,-0.006239107,-0.035883274,0.011209621,-0.04628537,-0.0029317487,0.027783869,0.0014429465,-0.08480664,0.084299475,0.015522489,0.010487965,0.0060523483,0.16914538,-0.043386064 +4.2.1.34,Also hydrates fumarate to (S)-malate.,384,1.0,0.03750241,0.009717655,-0.02405703,0.03789422,0.06322701,0.085066974,0.021113895,0.01161823,0.074701495,-0.025513314,-0.018443726,-0.046183035,-0.036443725,0.0022766327,-0.047297824,-0.06527357,-0.0124825565,0.039142538,-0.032560956,-0.009125445,0.09020556,0.021636883,0.027415961,0.021749217,-0.011297384,-0.007472335,0.007162381,0.011234588,-0.0023586666,-0.076520555,-0.015733998,0.0027378602,-0.02041219,-0.025826598,-0.10179977,0.06912839,-0.014514771,-0.030689532,0.057676088,0.021109235,0.02201968,-0.024399634,-0.012585065,-0.030005468,0.0057040867,-0.0010669326,-0.022007432,0.08282247,0.06813879,0.0807413,-0.04442098,-0.08357038,-0.06469178,0.01639326,-0.03203515,0.028438631,-0.062373325,-0.026971538,-0.09189992,-0.024738148,0.04322713,0.076053426,-0.051875617,0.011015893,-0.026868332,-0.024875563,0.019494502,0.054485615,0.02902019,-0.031574458,-0.013683511,-0.033625834,0.032628335,0.036089063,-0.075701825,0.037243534,0.018732226,-0.023644637,-0.00060720654,-0.0068302187,-0.009131274,0.052205987,0.07933485,0.038914524,0.03095135,0.0048708017,-0.03811091,0.02934838,0.012464965,-0.021424862,0.06408992,-0.014150515,-0.026660815,0.010279156,-0.06448398,0.014492603,0.05013329,0.025511157,-0.03828742,-0.028640097,-0.031629704,0.04203862,0.04444733,-0.042556763,0.000601271,0.039476797,-0.007719266,-0.0152900955,0.020424679,-0.08088268,-0.07838221,-0.024896596,0.055889755,0.03535262,-0.054412466,0.06433892,-0.020730421,-0.029691465,-0.06647342,0.029637393,-0.038649246,-0.017348958,0.059532754,0.021569695,0.0009772008,0.009188641,-0.059726782,-1.9330808e-33,0.019263154,-0.023183655,0.09780834,0.03749694,0.014596713,-0.03307235,-0.058081273,-0.05678093,0.006103967,-0.03982195,-0.13370684,-0.03930999,-0.047930658,0.007278683,0.02284924,0.007494689,0.024215085,-0.05437142,0.00036343883,-0.04724771,-0.024301082,0.049331736,0.012587883,-0.09188554,0.026969519,-0.026462039,0.07730612,0.041805115,0.047496945,0.01764035,0.01105082,-0.041403793,0.01598069,0.029954392,-0.044810154,0.070106015,-0.12356252,-0.054251697,-0.023571461,0.04688161,0.11624316,0.014997488,0.014261407,0.016507534,0.0007165123,-0.021366406,-0.079248376,0.05171328,0.04032245,-0.039816894,0.043282393,0.03200341,0.006207331,0.068631686,-0.05936837,0.0050533153,-0.010754912,0.01836908,-0.04259578,0.097654246,-0.07301187,-0.019195667,0.012879171,-0.012436857,0.024015386,0.02587489,-0.07554687,-0.021368537,0.004375508,0.006291962,-0.06802185,0.03509457,0.11589299,0.122820556,0.005505408,-0.04583409,0.10254237,-0.06330889,-0.0313241,0.037405744,-0.014250718,-0.07993862,0.030272037,0.07350605,-0.07711098,-0.041536964,0.0066215945,-0.040611897,0.09119701,-0.024175828,-0.058088634,-0.0272499,-0.09198098,-0.02313051,-0.032323033,-2.2451775e-34,0.07147561,-0.106157266,-0.0010292216,0.06597806,0.050793916,0.046941396,-0.0012669974,-0.053923666,-0.01216267,-0.009898396,0.034683257,-0.017363474,0.014400173,-0.1068384,-0.022062184,0.06204049,0.06243228,0.04215282,-0.022330228,0.0036051534,-0.073403,0.08710403,0.0523793,-0.016518421,0.025265517,-0.00035644558,-0.01629026,-0.047674898,-0.052555308,0.120239146,0.11338755,-0.00616877,-0.055290952,-0.10691966,-0.052153792,-0.024942683,0.029045338,-0.04485969,0.019216735,0.10091042,0.061207466,-0.0173254,0.1215981,0.009643587,0.080673724,0.066925064,-0.004373496,-0.084678166,-0.03197203,-0.05788363,0.107344374,-0.08350783,-0.05798205,0.07054035,0.10828372,0.011845455,-0.027801216,-0.038606763,-0.057683166,-0.049129277,-0.014587423,-0.0063451706,0.02183487,-0.14792825,0.016950646,-0.021441568,-0.068198755,0.08056452,0.059751563,0.013420766,0.06492776,-0.032864466,-0.014233027,0.1133922,0.031367525,-0.013184351,-0.07518858,-0.053843632,-0.005992707,-0.049510315,-0.0170182,0.029652864,-0.056373652,-0.06101221,0.022013377,-0.045916405,0.0046143057,0.046435792,-0.010079522,0.019768076,-0.062324792,-0.07349066,-0.037767116,0.10992711,0.064590655,-1.6855864e-08,0.059973445,-0.03445699,0.01671248,0.071961336,-0.0910646,0.0016585329,0.025033144,0.07225193,-0.033776693,-0.026111996,-0.06737074,0.07973597,0.047033846,0.032360256,-0.024233742,-0.008338612,0.0103978105,0.09226762,-0.059190445,-0.07739453,-0.06425461,0.05376608,0.0011028216,-0.014506328,0.029231053,-0.041240454,-0.006264565,-0.008748219,0.065252945,-0.027795695,0.052116625,-0.01244588,-0.0029637753,-0.055353962,0.021526122,0.060962323,-0.005436993,-0.018323088,-0.021561107,0.079586275,0.052590266,-0.012984527,-0.041559026,0.04759682,0.031403888,-0.039815865,0.008320805,0.11839308,-0.03396151,-0.06596807,0.07595681,0.056624636,-0.007881574,-0.010048399,-0.071171775,0.0026807967,-0.025171556,-0.040940054,0.04246639,-0.08942833,0.025039928,-0.08911172,0.13808687,0.00031378385 +4.2.1.35,Requires Fe2+.,384,1.0,0.0017429227,-0.0120922215,-0.038558863,0.09142432,0.06785902,-0.058863577,-0.01458679,-0.014261219,-0.07332533,-0.05796829,-0.011215821,-0.015509965,-0.07202684,0.04249708,0.024249421,-0.03321543,0.019945407,-0.020375494,0.030671543,0.04413522,0.05039896,-0.076645784,0.061869685,-0.0806471,-0.07299566,0.021112347,0.025108593,0.011541391,0.031364482,-0.07522699,-0.013137532,0.024824042,0.00782358,-0.025159573,-0.07306664,0.037389968,0.028623296,-0.041204736,-0.07766069,-0.044195645,-0.092444964,-0.051226787,0.004661776,0.019761538,0.016014727,-0.08959922,0.10965217,-0.073083736,0.07675235,0.025391651,-0.047817487,0.012119977,-0.019110482,0.06658772,0.051607575,-0.03403417,0.020699611,-0.032469366,0.0004800927,-0.011221626,-0.017793885,-0.06576893,-0.036475454,0.05335543,0.06464099,0.022822551,0.047862507,-0.07560602,-0.05039111,0.036225423,-0.025612224,0.03532552,-0.052344717,-0.028691012,-0.016723612,0.03522456,0.07033103,-0.055389967,0.12350712,0.0123082185,-0.123151205,-0.03510367,-0.03319499,0.027769485,0.08925549,0.071048334,-0.042034563,-0.054983024,-0.099674575,0.055655226,0.028191065,0.060977615,0.023211394,0.05470533,0.03721542,-0.0003429361,0.0072218375,-0.019805033,-0.08760099,0.06914633,-0.09391643,0.05948289,-0.02463003,0.067270935,-0.015539489,-0.028376048,-0.031077085,0.06590933,-0.0741654,0.0145040555,0.07959369,-0.0071991794,0.03405784,-0.004239101,0.03415664,0.02927697,-0.0066822385,-0.003935083,0.025430325,0.02711847,0.076907285,0.034331284,-0.06844991,0.025891433,-0.060349308,-0.089497626,-0.018967083,-2.074728e-33,0.03875058,0.09118988,-0.0090543805,0.06307697,-0.019233564,0.035965927,-0.06977131,-0.034298696,-0.03491918,0.013025775,-0.051146638,-0.037127115,0.012320491,-0.006813886,0.08286553,-0.12027711,0.062278084,-0.0055497363,0.08970242,-0.0406022,0.06444415,0.01447369,0.01988652,-0.07293302,0.043469448,0.12426544,0.011997116,-0.021612443,0.012783716,0.044091817,0.034164663,-0.05379804,-0.05068308,0.012276918,0.032229804,0.026016157,-0.051090825,-0.02843097,-0.012233348,-0.02187568,-0.010255581,0.07091546,-0.048615243,-0.031659544,0.042125147,-0.101625815,0.0625771,0.08382098,0.008944647,0.108518094,-0.041440237,0.015257649,-0.0135497,0.03280594,-0.008964016,0.0077318638,0.04506646,0.0095773125,0.060724284,0.096419096,0.007831181,0.0152376685,0.09397592,0.07084752,0.008463016,0.0075988555,-0.037691083,0.06428395,-0.022946876,0.04885402,-0.04825891,0.054102004,0.101672865,0.012057786,0.039643303,-0.04500026,-0.039373722,-0.10287057,0.05524383,0.014613132,-0.080241226,-0.04578716,-0.008564254,0.006317822,-0.01804736,-0.030574838,-0.055968333,-0.005918972,0.03520392,-0.021981578,0.021104828,-0.063459106,0.028721329,-0.046397213,-0.032900482,1.9423185e-33,-0.050131872,-0.07233176,0.006517437,-0.009770115,0.0012152584,0.03262746,-0.026354922,-0.17247894,-0.019856434,0.081106424,0.02197408,0.05406422,0.04717696,-0.04765909,0.060986374,0.03714663,-0.064488016,-0.05029234,0.0886715,-0.009229691,0.0075599453,0.08849569,0.027635824,0.04191214,0.039998353,0.05784655,-0.032710597,0.009904373,0.018160459,0.054377098,0.05682356,0.02135305,-0.09520718,-0.037526492,-0.050535947,-0.08163383,0.08369463,0.043726932,0.0040038014,-0.003337331,0.037788805,0.036244527,-0.0042140274,0.14379315,-0.04684554,0.013663093,0.07926568,-0.020665063,0.030223744,0.05057593,-0.018513858,-0.086178035,-0.07583318,-0.03216732,-0.025714448,-0.06935636,0.028185032,0.059341352,-0.026195612,0.029161802,0.062405966,-0.021127302,0.07086086,-0.05336216,0.03923583,-0.052638926,-0.013585774,0.13479158,0.02843234,0.049202528,0.04161349,0.09417971,0.10558358,-0.06084688,-0.021666436,0.0059049153,-0.015171688,0.037239682,0.025117068,-0.019119684,-0.02553583,0.00070164853,0.0087346425,-0.04532933,0.030254306,-0.12709531,0.025486352,0.0056386716,-0.031363763,-0.0065417024,-0.044666093,0.03406188,0.051363,0.020588111,-0.08177112,-1.4773268e-08,-0.07523463,0.0011237485,0.016023146,-0.042561483,0.008760203,0.0085942,0.04015263,-0.031745512,-0.028120264,0.0130028855,0.03657854,0.03740095,0.09984513,-0.0011536697,0.05729272,-0.034588095,0.019776205,0.089067765,-0.07187036,-0.05924737,-0.080893286,-0.041323666,-0.033375647,0.0396294,0.011878222,-0.019456035,-0.0046423576,-0.029919215,0.07149047,0.021430269,-0.058517,0.0038932343,-0.027600368,-0.023435276,-0.02749246,0.027492367,0.0054548956,0.009215663,-0.013423877,-0.050297283,-0.012353761,0.062447686,-0.02013099,-0.022789508,-0.031834174,0.0075663156,-0.07518661,-0.059446964,-0.055041708,-0.0062214406,0.053594608,-0.006450981,0.023155697,-0.008346988,0.014302364,0.09564623,-0.009267767,0.011880439,0.09211617,-0.026712509,0.060796443,-0.03838758,0.041849215,-0.062430806 +4.2.1.36,"Requires a [4Fe-4S] cluster for activity. The enzyme from the hyperthermophilic eubacterium Thermus thermophilus can catalyse the reaction shown above but cannot catalyse the previously described reaction, i.e. formation of (R)-homocitrate by hydration of cis-homoaconitate. The enzyme responsible for the conversion of cis-homoaconitate into (R)-homocitrate in T. thermophilus is unknown at present but the reaction can be catalysed in vitro using aconitate hydratase from pig (EC 4.2.1.3) [2].",384,0.99999994,-0.025910897,0.014053757,-0.07878918,0.03966266,-0.007887949,0.07082727,-0.10249585,0.024217637,0.0053633843,0.023495378,0.009271092,-0.13607025,0.017075168,0.04058355,-0.020877399,-0.0034329034,-0.010512986,-0.0058496716,0.033258025,-0.04121691,0.054670792,-0.053739488,0.0020485178,-0.03706058,-0.051144887,0.05295046,0.08761939,-0.053783257,-0.10160834,-0.010940758,-0.035425533,-0.07260189,0.02869255,-0.09301248,0.03301453,0.02700934,-0.030898765,-0.09364338,0.1519083,-0.015181285,0.052706957,-0.008818223,-0.0011323185,0.006067714,-0.03918578,0.023416793,0.017642999,-0.00733331,0.005257621,-0.049278866,-0.015146607,0.019957647,-0.012390261,0.022073278,-0.04624205,0.04441759,-0.088063784,-0.080912925,0.030605158,-0.0986283,0.084288046,-0.017071689,0.025354305,-0.012897005,0.04049503,-0.035956383,0.056233175,-0.023006195,0.018541457,-0.006563047,-0.08094417,-0.0059454907,-0.015594986,0.014926456,0.027198164,0.031555165,0.012726232,-0.019915598,0.090969265,-0.021936813,0.024561673,-0.02179184,-0.028725572,0.02699438,0.00010080065,0.01602593,0.07644623,-0.014923548,0.0893329,0.0071950667,-0.0136124985,0.021800658,-0.025159385,-0.042709287,-0.07292831,-0.027658837,-0.027842103,0.07226084,0.054353252,-0.07058977,0.0040643667,0.037433427,-0.052458905,-0.043047532,-0.007865678,0.006353808,-0.034753248,0.11142141,0.097612515,0.021532478,-0.055533253,-0.07481998,0.037935197,0.014150748,-0.018437896,0.121451706,-0.010361348,-0.027049601,-0.08556946,0.04668982,0.027295368,-0.022791432,0.05212273,0.043204207,-0.0324836,0.015414577,-0.1008502,3.5839963e-33,0.0749758,0.012233958,-0.002265139,-0.017041935,0.078710005,0.05476968,-0.11333272,-0.013187943,-0.043111376,-0.06108243,-0.100664504,-0.036234166,0.057633117,0.0040959017,-0.0780054,-0.05469335,0.017304517,0.047933705,0.03644904,0.006756494,-0.039042763,0.11568458,0.06575209,0.033609316,-0.03262925,0.069781266,0.0063743745,-0.005616341,0.082376525,0.037288986,-0.04360922,-0.09730566,-0.12119333,-0.004246452,0.04679291,0.021829747,-0.018429153,-0.050372213,0.0011797979,0.058700744,0.050570533,0.006520852,0.013109081,0.01060241,0.022446195,0.02993372,-0.04782756,0.078690976,-0.022457218,0.054226335,-0.029299086,-0.031052899,0.070450686,-0.00092302583,-0.06684492,-0.005191276,-0.02088366,0.056484748,0.08899464,0.0041648983,-0.0005587396,0.09821999,-0.057407714,0.013050319,-0.010870302,0.059446495,-0.05210314,-0.01195051,0.003931801,0.06929553,-0.044583123,0.017998211,0.0051257582,0.0312627,0.01569166,-0.027329108,-0.056518514,-0.031736508,-0.01800161,-0.022727294,-0.026652964,0.048890084,0.041336555,-0.032014444,0.059208408,-0.056177024,-0.062520206,0.03611901,0.011803231,0.011478614,0.058582947,-0.056610562,-0.035653733,-0.009508079,-0.0063336333,-4.8458373e-33,0.11830737,-0.12328625,0.005330357,-0.044575285,-0.011392606,0.043904055,0.03153183,-0.049253225,-0.017314337,-0.020693853,0.11486768,-0.034963336,0.021021146,-0.035704285,0.042281523,0.025000745,0.032203317,0.055463143,0.01035891,-0.020101702,-0.007758097,-0.028157571,-0.039253175,0.044067036,0.00090494944,-0.006373682,0.03652514,0.032499176,0.0847824,0.037827086,0.0026910366,-0.024358172,-0.0804192,-0.041478936,-0.033254907,0.06767543,0.023434259,0.029476762,0.0697116,0.02463388,0.026144318,-0.059731744,-0.027209299,0.014138035,0.049060475,0.016098408,-0.07897526,-0.006825654,-0.032241,0.08546541,0.06465507,-0.06542529,-0.018405564,-0.07218016,-0.023857502,0.054569967,-0.001304848,-0.02110867,-0.049371637,-0.036921922,-0.031786647,-0.05653153,0.08045355,0.03130177,-0.012449365,0.09318509,0.010327488,0.009332858,0.06287637,-0.018371657,0.07743222,0.0148370275,-0.02316512,-0.040575173,0.08825832,0.0069233077,-0.043072145,-0.011074794,0.07882388,-0.016301058,-0.052080754,0.0047282106,0.09765892,-0.04431289,0.00459582,-0.08156407,0.06406961,0.11376065,0.004174814,0.035107356,0.012046241,-0.09073814,0.030366542,0.10313249,0.09653965,-4.296488e-08,0.00361347,-0.044438977,0.07385606,0.030555665,0.06179481,0.09202172,-0.08696336,-0.09031348,0.07124078,-0.09247454,-0.030872284,-0.001739558,0.013092301,0.021064289,0.04066855,-0.0058923834,-0.020907644,0.008819915,-0.03557177,-0.02409707,-0.09721461,-0.037131537,-0.044030376,0.011342231,0.045513503,-0.030587688,0.03407423,-0.054966155,-0.06429342,-0.1080355,-0.0762809,0.0046205185,-0.08937374,-0.031951826,-0.04647954,-0.035057493,0.0037983013,0.008236638,-0.004225169,0.02516236,0.04271039,0.034310073,-0.07363583,0.026333109,0.030034577,0.04616692,-0.042202193,0.010990294,-0.11290103,-0.009004934,-0.020126447,0.0691523,-0.044588,0.017141808,-0.09378423,0.0064173476,-0.05095506,-0.06672417,-0.09034717,-0.0032042237,0.0018827223,0.011367684,0.105962045,-0.03919019 +4.2.1.39,"The enzyme shows no activity with D-galactonate [2]. cf. EC 4.2.1.140, gluconate/galactonate dehydratase. ",384,1.0,-0.035527956,-0.11194313,-0.026733002,-0.069057114,0.028034829,-0.03954906,-0.07864073,0.037535187,-0.027393177,-0.016770637,-0.0006171919,-0.050888784,-0.07080578,0.08195396,-0.06812738,0.011331508,0.001516688,-0.028786175,0.042486627,0.049937673,0.09086577,0.007488115,0.035138372,0.034115642,0.1364331,0.012355338,0.06338515,-0.04024974,-0.065294296,-0.055915613,-0.007951002,-0.026765602,0.047605917,0.011672139,0.04131095,0.09689942,-0.019975057,0.0030144104,-0.00778612,0.003197019,-0.008771214,-0.050621126,0.022385698,-0.016390491,-0.021197475,-0.011703675,-0.043404777,0.028967978,-0.021558398,0.01829717,-0.03320942,-0.10434937,-0.0006485625,-0.026101094,0.021974217,0.04579284,0.013292499,-0.0005301077,-0.04852876,0.0011668985,0.08062129,0.03436127,0.029423367,-0.016712626,0.018796703,-0.011996186,0.026479144,-0.03163672,0.011492811,-0.045330625,0.038156804,-0.08716579,-0.011735881,0.004123504,0.0024856168,-0.010439705,-0.012872402,-0.056037214,0.04883299,-0.08891556,0.028261783,0.0025648212,0.038849473,0.042198107,0.020582182,-0.012507956,-0.023560723,0.034774624,0.045607343,-0.040852893,0.024590695,0.01594278,-0.11091325,0.010698498,-0.04215098,0.04348686,-0.019235952,0.032819234,-0.026645755,-0.028818438,0.0039855214,0.051664624,-0.08581974,-0.002927421,-0.0016328117,0.055166304,0.043387085,0.072047606,-0.03307952,-0.03968403,0.054348823,-0.014619209,0.07617275,0.078017846,-0.07501061,0.055989586,0.049614843,-0.03364174,-0.14783385,0.0483561,0.031990066,-0.0012480621,0.09887776,0.024221016,-0.014603345,0.087209165,-0.027656268,-3.435681e-34,0.08701673,-0.028773703,0.016665924,-0.0066280724,0.028304813,0.05302528,-0.06205334,0.0005644302,0.005713852,-0.014880512,-0.080049366,-0.0077902996,0.04293891,0.007801927,-0.02216599,0.06331668,0.11693528,-0.04563828,0.028875757,-0.0046068053,0.112271436,0.056452155,-0.0791929,0.044399343,-0.004157527,0.0414022,0.029610055,0.054868188,0.10732475,0.012038841,-0.07693489,-0.13499546,-0.013471384,0.00082942675,0.01836878,0.03780743,-0.09840704,-0.04137914,-0.02125214,-0.025440844,0.017744293,-0.017047197,-0.023436226,-0.068607345,-0.013441813,-0.0001824022,0.013932604,0.07772421,-0.013282511,0.07243406,0.07643349,-0.022957476,-0.003972599,-0.023583602,-0.035136826,0.045712486,-0.0774198,0.0299175,0.050831597,0.067189164,0.033296365,0.06443287,-0.028318634,0.02257336,-0.006549355,0.01333909,-0.04018046,-0.018189356,-0.05787316,0.014328148,-0.048921864,-0.077583194,0.062275402,0.047714654,0.0015175915,-0.064368196,0.0078217415,-0.036694907,0.001045261,-0.056416217,0.026013726,-0.019737864,0.020717634,0.02031303,-0.0034458055,0.034007818,-0.060252503,-0.03377589,-0.040011127,0.05572879,-0.027791202,-0.028708244,-0.073245145,0.0040007886,0.0017578327,-9.670999e-34,0.025726277,-0.056414187,0.06385191,-0.054016605,-0.038662154,0.12568493,0.027918382,-0.026941042,0.09623939,-0.054891773,0.113360845,0.00182996,-0.10116141,-0.08466554,-0.045127764,0.084677994,-0.032171104,0.028120555,-0.05817503,0.032641664,-0.00022228007,0.115454264,-0.018280612,0.067700095,0.040019386,0.0035030993,0.0416489,0.06459384,0.037517443,0.027749391,0.05681709,0.04758426,-0.03914685,-0.1143872,-0.07641792,0.062940925,-0.07725718,-0.038670585,-0.044268057,0.015244599,-0.041125856,0.044659115,0.027766142,0.07091913,0.047358487,0.085437655,-0.069988705,-0.0061863055,0.025676476,-0.037534572,0.032793857,-0.066107556,0.017887006,0.04827045,0.043179907,0.011806038,0.089098625,0.056491155,-0.020431897,0.0118613,0.015340081,-0.0464627,0.0006112614,-0.07518163,0.07026875,0.009543247,-0.027149634,0.11212236,0.051496465,-0.015254976,0.07663245,-0.013631085,-0.024610305,0.03629412,-0.033989146,0.040614363,-0.10843812,-0.033707514,0.022806296,-0.10695177,0.024890533,0.0435986,0.013778131,-0.021035554,0.0138783865,-0.050989132,0.034731507,0.09591739,-0.012510523,0.06880134,-0.07273255,-0.007944329,-0.018883003,0.01596738,0.08466318,-2.784526e-08,0.08188278,-7.05207e-05,0.04778951,-0.10954461,0.002807776,-0.026372014,0.020835375,0.0072708805,0.022209112,-0.032200735,-0.08242763,0.057583608,-0.044485454,-5.128393e-05,-0.024462862,0.016095528,0.034020323,0.023052415,-0.07287391,-0.0005381144,-0.036737,0.011484697,-0.1523565,-0.020370584,-0.027760658,-0.045203175,0.06764756,0.049379215,-0.004968841,-0.08493658,0.04083471,0.044463195,0.052775733,-0.04033576,-0.06864223,0.048918474,-0.04562506,-0.0023170297,0.008304377,0.022338279,-0.04100215,-0.0522683,0.037066523,-0.008657254,-0.06943916,-0.0018233595,-0.024994776,0.009391598,0.0021934223,0.055086818,0.030255884,0.0032721402,-0.0761765,-0.059035942,-0.07245639,0.029649844,0.02943923,-0.054263093,0.0064433515,-0.12623022,0.057846073,-0.12875898,0.03910122,-0.037890546 +4.2.1.42,"The enzyme from the bacterium Escherichia coli is specific for galactarate [2], while the enzyme from Salmonella typhimurium also has activity with L-talarate (cf. EC 4.2.1.156, L-talarate dehydratase) [3]. cf. EC 4.2.1.158, galactarate dehydratase (D-threo-forming).",384,0.99999994,-0.02013134,-0.142307,-0.010342361,-0.021987155,0.049271215,0.013506912,-0.0370756,0.077073686,0.0040738527,-0.05592005,0.031826466,-0.040444,-0.06780306,0.08697812,-0.029856132,-0.035383888,0.0005227742,-0.03381007,0.054367453,0.0013317525,0.1365526,-0.024366561,-0.0021104978,-0.00068115164,0.09104704,-0.016248697,0.04401234,0.0033597066,-0.046612024,-0.10837369,-0.02854935,0.022019168,0.1084906,-0.09497859,0.03632922,0.05002513,-0.032511454,-0.020491175,0.098308995,-0.0010685851,0.007276145,-0.0114002675,0.007212966,-0.02765603,-0.068190016,-0.0044641993,-0.0018946057,0.100319736,-0.021320216,-0.005563947,-0.0735705,-0.05696867,-0.017833004,-0.027890693,0.022478344,0.00056358386,0.02735066,-0.09079735,0.014230635,-0.037055895,0.06684198,0.048598155,0.052197736,-0.005766646,0.027862338,-0.07561266,0.06435039,-0.05433506,0.031538233,-0.07489699,-0.047133464,0.0046708817,-0.0015469057,0.07529368,-0.064717986,0.019875092,0.029263465,-0.039006066,0.060557343,-0.014180253,-0.038913008,0.021399327,0.037996385,0.0045025293,0.0056835837,-0.07044252,0.007912962,0.06789891,0.05835898,-0.002977888,0.055319387,-0.0052389135,-0.047832463,-0.07095157,-0.07347832,0.03172532,-0.01601994,-0.024153626,0.029534463,-0.06821994,-0.0125109665,-0.019752098,-0.026384758,-0.028834352,0.050647628,0.00087807566,0.038206793,0.049992453,0.055863526,-0.010701657,0.024720594,-0.008585181,0.067923464,0.05182525,-0.08913949,0.018804986,-0.0054311072,-0.045867495,-0.061135557,0.07014233,0.009144356,-0.0805547,0.0843594,0.037605178,-0.0028267524,0.039534636,-0.07403365,1.770706e-33,0.09326312,-0.011015159,-0.007854643,-0.078149654,0.10004975,-0.044737816,-0.045357767,-0.022273377,-0.019341651,-0.00064191973,-0.11586896,-0.059094366,0.01457581,0.035074424,0.025753824,0.07725188,0.0043165707,0.006500656,-0.05383816,0.029930076,0.030532198,0.0768197,0.027320199,-0.016855331,0.06900171,0.053296782,-0.0005047611,0.03325122,0.06610835,0.026423337,0.04554271,-0.10675172,-0.06903138,0.074883156,0.120001554,0.0049582412,-0.06672929,-0.06345815,-0.028427258,-0.022363042,0.033747844,0.06157223,0.020462692,0.022312704,0.01022434,-0.05235413,0.00645028,0.06679468,-0.020977465,0.008715436,0.04735113,0.029719723,0.016086437,-0.08251007,0.0371131,0.044430483,-0.027752588,0.06927667,0.048612133,0.081574775,0.016974177,0.10417619,-0.026180126,0.033403575,0.03408179,0.02283906,0.033783562,-0.03977879,0.005721418,0.019500718,-0.031995256,-0.06682661,0.057051238,0.083731726,-0.049593486,-0.045465495,-0.018865414,-0.08571724,0.0333764,-0.09478553,-0.013554881,-0.009496798,0.03199944,-0.045973584,-0.0644666,0.02860207,-0.03368129,-0.0021696894,0.0046479437,0.031421203,-0.0130106965,-0.02476036,-0.05639906,0.017405134,-0.019809252,-2.3711387e-33,0.031521108,-0.04373771,0.07996874,-0.10488989,-0.09018375,0.087175906,0.007303813,-0.042474315,0.06626633,-0.006805866,0.054056093,0.037609316,-0.063402474,-0.062769964,-0.024018317,0.04065502,0.098423645,0.046424784,-0.13016617,-0.079084404,-0.03805296,0.039457288,-0.015276952,-0.014894874,-0.0033285238,-0.008682424,0.020893741,0.06372474,-0.044790782,0.019854262,0.036103107,0.052223716,0.024853468,-0.12112113,-0.056067325,0.006948355,-0.045460545,-0.028302852,0.05376529,0.0037486583,0.03130226,0.019492049,0.0629141,0.04952961,-0.011707215,0.030515932,-0.080942705,-0.040913105,0.039710432,-0.039415464,0.011048528,-0.11906486,0.07036608,0.0003903814,0.007767208,0.0034667284,0.014351216,0.029146593,-0.078049876,-0.043911304,0.0047762264,-0.019757237,0.0974738,-0.05456249,0.0636203,0.02879123,-0.03536204,0.03857373,0.010533185,-0.009315684,0.020934638,0.017731136,-0.01310306,0.061491244,-0.069467075,0.005718669,-0.072445996,-0.04069935,0.044143233,-0.062031046,0.075771235,0.030000301,-0.06194099,-0.04481119,0.01571884,-0.023423087,0.045882512,0.15065125,0.045761086,0.041324362,-0.04617192,-0.055833805,-0.028519278,0.016437655,0.12111125,-3.928503e-08,0.06770686,-0.020923728,-0.0033797873,-0.06269106,-0.020858651,0.029119229,-0.04819319,-0.02541887,0.07342892,-0.035092104,-0.03513016,0.123515874,-0.0119731,-0.0116854645,0.0058381506,0.0077462676,0.01189877,0.0072464733,-0.03697484,0.015944345,-0.0110503705,-0.020438485,-0.079119965,0.008069395,0.03286376,-0.049833197,0.015178775,0.0066975006,-0.018448524,-0.01806661,-0.011882214,0.044098847,-0.0034983444,-0.023363583,-0.032266747,0.021924676,-0.07841018,-0.026595898,0.012358766,0.09659638,0.09083884,-0.009152393,-0.06310071,-0.03138984,-0.043495122,0.04021315,-0.06545981,0.027869737,-0.035037287,0.0015870107,0.024285708,-0.008047547,-0.028646177,-0.018962268,-0.08008545,0.018591626,0.0006563926,-0.08386174,-0.017932085,-0.06047246,0.08093176,-0.050678335,0.16988759,-0.00809549 +4.2.1.44,Requires Co2+ or 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+4.2.1.45,Requires bound NAD+.,384,0.99999994,-0.037167687,0.062260464,-0.047178224,-0.030752042,-0.06184523,0.06739017,-0.020425849,0.039144,-0.011112973,0.027760727,-0.04546855,0.01376173,-0.0115470765,0.02576666,-0.024945246,0.021504544,0.005494145,-0.024023203,-0.043316517,0.046400245,0.05876792,-0.010163535,0.07634121,-0.030238114,0.045996066,-0.049026277,-0.0043220725,0.019148983,0.16140105,-0.04773472,-0.029935746,0.009371161,0.002364258,-0.00071589655,-0.045692768,0.05669852,-0.05530239,-0.02931946,0.0072530583,0.047715224,-0.0012352256,0.0133137265,-0.0098836245,0.08984055,-0.009362137,-0.015141485,0.006234049,0.06409584,0.02111274,-0.037490774,-0.06390057,0.029238682,-0.01394436,0.03600279,-0.02419328,-0.06318793,0.033236664,-0.07015953,-0.041982267,-0.012340186,-0.012952285,-0.07314389,-0.045555603,0.016338767,0.043986946,-0.025577642,0.090875745,-0.007419879,-0.09936632,0.08910578,-0.07365919,0.027682796,-0.02903781,0.085249335,0.030799117,0.06743206,-0.07970746,-0.090682216,0.10570569,-0.030608092,-0.014890305,-0.00472767,-0.10414002,0.026309514,0.09914989,0.01348428,-0.012796039,-0.06356331,0.044931088,0.012881576,-0.017302958,-0.03510309,-0.05417162,0.094495274,-0.095620126,-0.03982477,0.04607476,0.019744517,-0.05629053,0.06885265,-0.012656367,0.059767295,-0.035562344,0.0148599055,-0.040068507,-0.0014541312,0.071433514,0.044286832,-0.028814083,0.0332674,0.031162666,-0.015185752,0.07399721,-0.037070177,-0.027144983,0.046937943,-0.020589372,0.02891914,-0.0490645,-0.09918994,-0.03327033,-0.02012223,-0.017203448,0.016912948,0.021001436,-0.034270704,-0.03277668,-3.0468073e-33,0.09769356,0.016908873,0.023737786,0.09330709,-0.004821672,0.07788638,-0.06581439,-0.018440256,-0.109707914,0.0028216064,-0.0458758,-0.07790159,0.046957843,-0.06585557,0.14705887,0.06977696,0.060181092,-0.047062572,-0.032577567,-0.05524668,0.050140083,-0.028317118,-0.016078575,0.007267978,-0.0029697283,0.009632427,0.018194795,-0.032066662,-0.009083875,0.032156378,0.005273907,-0.068403505,-0.056624133,0.057175875,0.01767442,0.002277604,-0.05153229,-0.026178522,-0.011102575,-0.014818808,-0.054885976,0.0479007,0.009339045,-0.053150218,0.027740885,-0.13803923,0.09675833,0.11901357,-0.043467697,0.035029296,0.012470785,0.004250066,0.01620056,-0.018263876,0.01895715,0.03087307,0.007882838,0.055661127,-0.0054802448,0.15194428,0.013046253,-0.04500336,0.021877035,0.121690236,-0.087677635,0.06962243,-0.09101594,-0.0836303,0.11877574,0.053774323,-0.015063992,-0.013898717,0.022344468,-0.0011101591,0.009006533,-0.045950133,0.058975812,-0.04878899,0.023220077,0.031710744,-0.05467601,-0.04675422,-3.7774516e-05,-0.023935704,-0.034230873,-0.08795969,0.029068202,-0.057296026,-0.017862529,0.0038601754,-0.039439928,-0.024525449,0.028627565,-0.09850743,0.012157949,2.2027886e-33,0.046154328,0.006268388,0.0039384067,-0.030285427,0.037429474,0.0026280822,-0.0029559531,-0.086620264,-0.10268633,-0.045786746,-0.0018343553,0.055246677,0.039716724,-0.023506684,0.07021185,0.015182751,-0.022777693,-0.023121744,-0.021994568,0.037592392,0.026604842,0.07833533,0.0523189,0.055205863,0.0029782183,0.0016519292,-0.102590725,0.082846455,-0.08212108,0.005140394,-0.006959423,-0.0551158,-0.16776937,-0.036009345,-0.025662476,-0.07402511,0.04508783,0.038540132,-0.04936604,0.13402955,0.05304492,-0.012686193,-0.06102184,0.09213172,0.022566097,0.017653236,0.03883176,-0.028387902,0.058456115,0.0005445772,0.031657323,0.0011442682,-0.006977047,0.01889534,0.062023163,-0.017834155,-0.08177226,0.0514581,0.108124904,0.008551353,-0.00051013497,0.023521263,-0.017145218,-0.019367166,0.08000748,-0.028403739,-0.029572377,0.04465603,0.048661903,0.014779062,-0.014454361,0.057403196,0.029714165,-0.016857704,-0.03451001,0.0572704,-0.0653911,0.05049444,0.0071062106,-0.003302855,-0.056303024,-0.030636977,-0.04256842,-0.059785474,0.05895013,0.010255943,0.108407944,-0.048630208,-0.032550197,-0.010105467,0.028880635,0.059252374,0.022319963,0.017985027,-0.018257994,-1.34270435e-08,-0.0013894332,0.0011705253,-0.012298855,-0.0075653107,0.08691033,0.015488929,0.028180936,-0.03189621,0.009682323,0.12553279,0.08256967,0.069534115,0.046329103,0.102916606,0.022622561,-0.06461899,-0.085452415,-0.0077482113,-0.11966205,-0.07841535,-0.08880621,-0.017169783,-0.039042976,0.06585158,-0.010686644,-0.05937625,-0.0153497355,-0.045790236,0.046414785,0.018278932,0.029121324,0.0146069275,0.050374154,-0.02425516,-0.032940585,0.08301725,-0.027612561,0.03787808,-0.018062161,0.04203712,-0.032047912,0.03730067,0.0076104268,0.031572785,-0.0034903563,0.032626107,0.00052996894,-0.039511412,-0.03161888,-0.0054327245,0.020635303,0.02116667,0.027697373,-0.033509895,0.024739562,0.038760997,0.019928599,-0.02205893,-0.008621472,-0.03581783,0.03354164,-0.018153045,0.034184333,-0.02830947 +4.2.1.46,Requires bound NAD+.,384,0.99999994,-0.037167687,0.062260464,-0.047178224,-0.030752042,-0.06184523,0.06739017,-0.020425849,0.039144,-0.011112973,0.027760727,-0.04546855,0.01376173,-0.0115470765,0.02576666,-0.024945246,0.021504544,0.005494145,-0.024023203,-0.043316517,0.046400245,0.05876792,-0.010163535,0.07634121,-0.030238114,0.045996066,-0.049026277,-0.0043220725,0.019148983,0.16140105,-0.04773472,-0.029935746,0.009371161,0.002364258,-0.00071589655,-0.045692768,0.05669852,-0.05530239,-0.02931946,0.0072530583,0.047715224,-0.0012352256,0.0133137265,-0.0098836245,0.08984055,-0.009362137,-0.015141485,0.006234049,0.06409584,0.02111274,-0.037490774,-0.06390057,0.029238682,-0.01394436,0.03600279,-0.02419328,-0.06318793,0.033236664,-0.07015953,-0.041982267,-0.012340186,-0.012952285,-0.07314389,-0.045555603,0.016338767,0.043986946,-0.025577642,0.090875745,-0.007419879,-0.09936632,0.08910578,-0.07365919,0.027682796,-0.02903781,0.085249335,0.030799117,0.06743206,-0.07970746,-0.090682216,0.10570569,-0.030608092,-0.014890305,-0.00472767,-0.10414002,0.026309514,0.09914989,0.01348428,-0.012796039,-0.06356331,0.044931088,0.012881576,-0.017302958,-0.03510309,-0.05417162,0.094495274,-0.095620126,-0.03982477,0.04607476,0.019744517,-0.05629053,0.06885265,-0.012656367,0.059767295,-0.035562344,0.0148599055,-0.040068507,-0.0014541312,0.071433514,0.044286832,-0.028814083,0.0332674,0.031162666,-0.015185752,0.07399721,-0.037070177,-0.027144983,0.046937943,-0.020589372,0.02891914,-0.0490645,-0.09918994,-0.03327033,-0.02012223,-0.017203448,0.016912948,0.021001436,-0.034270704,-0.03277668,-3.0468073e-33,0.09769356,0.016908873,0.023737786,0.09330709,-0.004821672,0.07788638,-0.06581439,-0.018440256,-0.109707914,0.0028216064,-0.0458758,-0.07790159,0.046957843,-0.06585557,0.14705887,0.06977696,0.060181092,-0.047062572,-0.032577567,-0.05524668,0.050140083,-0.028317118,-0.016078575,0.007267978,-0.0029697283,0.009632427,0.018194795,-0.032066662,-0.009083875,0.032156378,0.005273907,-0.068403505,-0.056624133,0.057175875,0.01767442,0.002277604,-0.05153229,-0.026178522,-0.011102575,-0.014818808,-0.054885976,0.0479007,0.009339045,-0.053150218,0.027740885,-0.13803923,0.09675833,0.11901357,-0.043467697,0.035029296,0.012470785,0.004250066,0.01620056,-0.018263876,0.01895715,0.03087307,0.007882838,0.055661127,-0.0054802448,0.15194428,0.013046253,-0.04500336,0.021877035,0.121690236,-0.087677635,0.06962243,-0.09101594,-0.0836303,0.11877574,0.053774323,-0.015063992,-0.013898717,0.022344468,-0.0011101591,0.009006533,-0.045950133,0.058975812,-0.04878899,0.023220077,0.031710744,-0.05467601,-0.04675422,-3.7774516e-05,-0.023935704,-0.034230873,-0.08795969,0.029068202,-0.057296026,-0.017862529,0.0038601754,-0.039439928,-0.024525449,0.028627565,-0.09850743,0.012157949,2.2027886e-33,0.046154328,0.006268388,0.0039384067,-0.030285427,0.037429474,0.0026280822,-0.0029559531,-0.086620264,-0.10268633,-0.045786746,-0.0018343553,0.055246677,0.039716724,-0.023506684,0.07021185,0.015182751,-0.022777693,-0.023121744,-0.021994568,0.037592392,0.026604842,0.07833533,0.0523189,0.055205863,0.0029782183,0.0016519292,-0.102590725,0.082846455,-0.08212108,0.005140394,-0.006959423,-0.0551158,-0.16776937,-0.036009345,-0.025662476,-0.07402511,0.04508783,0.038540132,-0.04936604,0.13402955,0.05304492,-0.012686193,-0.06102184,0.09213172,0.022566097,0.017653236,0.03883176,-0.028387902,0.058456115,0.0005445772,0.031657323,0.0011442682,-0.006977047,0.01889534,0.062023163,-0.017834155,-0.08177226,0.0514581,0.108124904,0.008551353,-0.00051013497,0.023521263,-0.017145218,-0.019367166,0.08000748,-0.028403739,-0.029572377,0.04465603,0.048661903,0.014779062,-0.014454361,0.057403196,0.029714165,-0.016857704,-0.03451001,0.0572704,-0.0653911,0.05049444,0.0071062106,-0.003302855,-0.056303024,-0.030636977,-0.04256842,-0.059785474,0.05895013,0.010255943,0.108407944,-0.048630208,-0.032550197,-0.010105467,0.028880635,0.059252374,0.022319963,0.017985027,-0.018257994,-1.34270435e-08,-0.0013894332,0.0011705253,-0.012298855,-0.0075653107,0.08691033,0.015488929,0.028180936,-0.03189621,0.009682323,0.12553279,0.08256967,0.069534115,0.046329103,0.102916606,0.022622561,-0.06461899,-0.085452415,-0.0077482113,-0.11966205,-0.07841535,-0.08880621,-0.017169783,-0.039042976,0.06585158,-0.010686644,-0.05937625,-0.0153497355,-0.045790236,0.046414785,0.018278932,0.029121324,0.0146069275,0.050374154,-0.02425516,-0.032940585,0.08301725,-0.027612561,0.03787808,-0.018062161,0.04203712,-0.032047912,0.03730067,0.0076104268,0.031572785,-0.0034903563,0.032626107,0.00052996894,-0.039511412,-0.03161888,-0.0054327245,0.020635303,0.02116667,0.027697373,-0.033509895,0.024739562,0.038760997,0.019928599,-0.02205893,-0.008621472,-0.03581783,0.03354164,-0.018153045,0.034184333,-0.02830947 +4.2.1.47,"The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-beta-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase [5]. Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues [6].",384,1.0,-0.04565365,-0.0025292526,-0.07200821,-0.040316243,0.023908906,0.040443473,-0.13372713,0.045251153,0.031784378,0.0012453914,0.0006596244,-0.02411565,-0.024534233,-0.0025449868,-0.034400795,0.024940128,-0.09067859,-0.01694107,0.00956372,-0.04006998,0.06773556,0.03968927,-0.065351054,-0.061320804,0.038283464,-0.056057103,0.091821834,-0.06904927,-0.106312856,-0.067544594,-0.005248647,-0.10827207,0.057399128,-0.03188068,0.047525298,0.11600433,-0.02668614,-0.03432495,0.0767011,0.0168067,0.0028364405,0.006935565,-0.035961047,-0.027449902,-0.0617981,0.053740676,0.0014581496,0.05963287,0.008875355,-0.005496186,-0.053889025,0.01808066,0.0025891329,0.021421187,0.03484904,0.007579768,-0.03620986,-0.025784468,0.012333467,-0.01817466,0.054767065,-0.06287618,0.031674594,-0.04730065,0.022856804,-0.076249376,0.09000073,-0.06834404,-0.05465283,-0.038812798,-0.06814115,-0.025451608,0.021138368,-0.01137505,0.017321961,0.04491741,-0.028840661,-0.027787596,0.015529755,-0.053999655,0.012364521,0.004480166,0.05597623,0.07247867,0.039856106,-0.055757415,-0.009510124,-0.025135795,0.08518947,0.06079953,0.006336832,-0.027506623,0.005152278,-0.018043213,-0.044220526,-0.021986568,0.00088862836,0.094984636,0.024058837,-0.0817525,-0.001368221,0.10849111,-0.01962072,-0.063611805,-0.033924278,0.01450837,-0.002061652,0.09723307,0.059835438,-0.014514435,0.02316624,0.019074451,0.07043382,-0.034512237,-0.06448713,0.04121678,-0.07307267,-0.07032036,-0.099103734,-0.016390676,0.07405904,0.0051588025,0.016828282,0.0782032,-0.024943724,0.0042762104,-0.14707288,1.9385843e-33,0.038806316,0.07356148,-0.016479332,0.02680309,0.05176309,-0.002709261,-0.089490585,0.04020775,-0.061160505,0.0043778606,-0.08685277,-0.06504068,-0.018399078,0.009264679,-0.05425942,0.03687467,0.023191445,-0.030306943,-0.012947629,0.061962288,-0.017996117,0.034477327,-0.009892138,0.0048993304,0.07561381,0.080763936,-0.016059557,0.012538921,0.009824536,-0.00030251616,-0.015809415,-0.1270179,-0.07418428,0.014298555,0.08227921,-0.047328714,-0.057463974,0.02491308,-0.04813088,0.0191284,-0.044615135,0.07266726,-0.049350988,-0.04874645,0.035987817,-0.013044805,0.051794726,0.06344383,0.024069076,0.08292247,0.011399595,-0.020697892,0.08895174,-0.070594475,-0.058425944,-0.011208374,-0.06622878,0.030932698,0.03557794,0.108507425,0.047970068,0.063691966,-0.023705682,0.05877557,-0.019304102,0.013734751,-0.00040110518,-0.010700524,0.05939392,0.013504686,-0.035202373,0.028316608,0.12836063,-0.006757188,-0.0032822203,-0.018855058,-0.02700551,-0.08205646,0.044881903,-0.06296468,0.0023518146,0.013984038,-0.060665168,-0.054564744,-0.007851527,-0.020034082,-0.03968728,-0.054457087,3.2698368e-05,0.059460882,0.0010641539,-0.105321,-0.057366762,0.0089065125,0.04641225,-3.38948e-33,0.1066815,-0.08528305,0.0418744,-0.13395348,-0.04474178,0.0698627,0.0931209,0.008048212,-0.006146144,-0.03789623,0.055443052,0.00572711,-0.012834102,-0.011704801,0.039084956,0.07190546,0.008668797,0.075269416,-0.030595707,-0.049625628,0.031388916,0.12557733,-0.013391315,0.025490563,-0.020803137,0.0531537,-0.043552123,0.09694355,0.058016676,0.042005498,-0.043938596,0.03106889,0.010956322,-0.0666774,-0.049249798,0.07372561,-0.06535275,-0.005608357,0.07882549,0.0315949,0.04462168,0.010948285,-0.03233255,-0.0059499675,0.06061647,0.026131952,-0.06481194,0.042117324,0.022546317,-0.09796502,0.095431425,-0.025287725,0.0021237307,-0.019599324,-0.0142846955,-0.0040366836,-0.014497004,0.032886207,-0.0135008,-0.036150746,-0.05456874,-0.08071913,0.09318024,0.057045054,-0.012012373,0.03499526,0.020903666,0.04213572,0.07331747,0.028003434,0.019637778,0.010158958,-0.026236432,0.032450948,0.0018540084,-0.052881874,-0.07398174,-0.04232559,0.028159782,0.05618459,-0.04468342,-0.0056745927,0.0011804902,-0.06565685,0.060403515,-0.06941268,0.06892292,0.046493396,-0.036483772,0.009218037,-0.037804455,0.0008333613,-0.022695921,0.089062154,0.000103568615,-4.287885e-08,0.09671445,-0.056798276,0.080213174,-0.024009869,0.08916476,-0.0011327065,0.009678549,0.010453654,0.0057291165,-0.002747506,0.010893453,0.08733265,-0.0004667434,-0.018254722,0.034935668,-0.013598017,-0.08368808,0.014170184,-0.027849605,0.013529045,-0.022042848,0.01970594,-0.14043376,0.023283478,0.02959166,-0.054394748,0.009368784,-0.068299435,0.0171974,-0.014010225,-0.009497733,0.05663106,-0.011219204,-0.05931099,-0.07574828,-0.05804772,-0.058289476,-0.0046265014,-0.0059577213,-0.009912812,0.029656887,-0.006100194,-0.023391275,0.048872314,-0.022506453,0.053215735,-0.049129177,-0.018872766,-0.02495523,0.065056995,0.030017419,0.009007084,-0.002958682,-0.021463359,-0.11944202,0.01402392,-0.0050626737,-0.023877598,-0.045798726,-0.057842627,0.045659125,0.014460044,0.14433597,-0.0768766 +4.2.1.48,Also acts on various derivatives of D-glutamate.,384,1.0,-0.07505614,-0.10130811,0.023670953,-0.0031627766,-0.037059475,-0.005745207,0.036974803,0.08373807,0.06516674,0.06888787,0.057291552,0.018604862,-0.040704314,0.064264074,0.043885723,0.00700831,-0.03390731,0.05037996,-0.08077147,0.011526274,0.04609961,0.107369065,0.006036307,-0.081642665,0.049416468,0.07729457,0.09759083,-0.01106346,0.06397017,-0.060753226,-0.0007423291,0.015889976,0.008703184,-0.001488237,-0.014749221,0.034521114,-0.10154244,-0.033364493,0.051847856,-0.04314383,0.061846867,0.055162102,0.035654992,-0.069054,-0.028920822,-0.023380468,-0.0065375776,0.00558957,-0.0027763946,-0.0009219336,0.08090287,-0.06788533,-0.028253695,0.04391391,0.03650956,0.016913556,-0.09610876,0.017638026,0.03141841,0.03246001,-0.030038914,0.028171387,-0.007260526,-0.006449444,0.05060292,-0.032687325,0.07372076,-0.044257414,0.064632095,-0.06882229,-0.035056863,-0.070541255,0.054796286,-0.030980492,0.0040238146,-0.037234444,0.046998613,-0.053552262,0.017786264,-0.082536705,0.076571554,0.04164698,0.09692553,0.031566463,0.008623329,0.04130555,-0.024511924,0.007464417,-0.0012667159,0.0327896,0.021282278,-0.060237747,-0.101286516,-0.03730984,-0.095669545,-0.02484441,-0.006410241,0.018868249,-0.009496548,0.0021453558,-0.009358045,0.07850144,-0.049522888,-0.060612764,-0.052637015,-0.017423216,0.030803962,-0.0027579167,-0.057988483,-0.030564142,-0.023303285,0.016899398,0.017492143,0.03250983,-0.11782983,-0.019562932,0.042888362,-0.017380653,-0.056005232,-0.02845543,0.031466957,-0.09896533,0.017533509,0.0078917425,-0.05373861,0.03434347,-0.021881055,-2.597838e-33,0.037911005,-0.07632013,-0.055578433,-0.03010074,0.06045493,-0.053948864,-0.071182884,-0.019768022,0.041605994,-0.03972472,-0.09729572,-0.019380696,0.004755945,0.01593572,-0.01983465,0.021219444,-0.058097206,-0.025888728,0.08384312,-0.065051034,0.07075073,0.09365468,-0.039413795,0.019606305,-0.005662057,-0.0036707046,0.030683955,0.092124425,0.066143185,-0.013787307,-0.031902377,-0.08189409,-0.052615706,0.04600682,0.023256315,0.10405407,-0.08535778,-0.021372246,0.032606866,0.04463047,0.00776211,-0.034066737,-0.12025103,0.016113734,-0.01656578,0.010084883,-0.056630865,0.02665867,-0.017266892,0.061697923,0.045569632,-0.068302736,0.034233417,-0.033538826,-0.051348083,0.016719224,-0.038888764,-0.063754134,0.06728667,0.09388771,-0.036330223,0.030262455,-0.06944864,-0.009560837,0.011219684,0.010530015,-0.07450202,-0.10603972,-0.025905378,-0.005843916,-0.045966767,-0.04279139,0.08663334,-0.012318006,-0.018879259,-0.04788131,-0.029765988,0.028595606,0.033960324,0.031670846,-0.020813726,-0.04965228,0.0034688285,0.04140093,-0.041444924,-0.018466668,-0.04511096,-0.110092476,-0.029915584,-0.018571408,-0.028874105,-0.0013468785,-0.037304647,-0.0021040575,0.04165006,-4.6386646e-34,-0.009454656,-0.016752841,-0.011741491,0.036133125,-0.02959954,0.06647813,0.0009120173,-0.017183855,0.027249949,-0.046979804,0.022420252,0.07193617,-0.068843566,-0.0013252009,-0.010718693,0.017510198,-0.043565903,0.07154464,-0.08169491,0.0012922292,-0.02937605,0.10241211,0.0150522515,0.07782712,0.07249971,-0.00058633945,-0.0053393045,-0.010125275,0.0020503392,0.13290235,0.021188894,0.0035898061,-0.06323268,-0.025069967,0.0015810903,0.040963713,0.05697757,-0.0037893818,-0.110207476,0.021637524,-0.0027604192,0.077888906,0.17202526,0.04612115,0.05302326,0.07280313,-0.00417659,-0.019614637,-0.08156791,-0.012110032,0.046599656,-0.0003935927,0.0018538337,-0.05387721,0.030510485,0.06488789,0.118116796,-0.073531196,-0.0360807,-0.016978612,-0.058467817,-0.0940245,0.028292807,-0.08965216,0.019621568,0.021150535,0.07482872,0.012364456,0.097086534,-0.049543355,0.08637285,-0.040842853,0.003953326,0.0063856444,-0.07874401,-0.067266576,-0.008548137,-0.037809946,0.05900328,-0.030725863,0.03731494,0.030145235,-0.017251587,-0.050624162,-0.061374806,-0.078704156,-0.032444492,0.111804456,0.043155562,0.0444523,-0.06121917,-0.0015176674,0.00093342847,0.076510586,0.06457406,-1.8237541e-08,0.0077095246,-0.06770044,-0.006249245,0.0011604546,0.0455682,0.032602765,-0.025980981,0.021023108,0.037425112,-0.01685773,0.025748005,0.12773053,-0.034683727,0.010653451,0.018320974,0.0461939,-0.021337371,0.066400014,-0.084089,-0.028525999,-0.059734583,0.0068753925,-0.031085676,-0.0076065795,0.05482507,-0.06532851,0.019319575,0.050308205,-0.028580805,-0.0012695548,0.016232649,0.04039511,-0.018882833,-0.048638318,-0.027614728,-0.0050846743,0.08709262,-0.0394358,-0.031994678,0.07651786,-0.0044192798,-0.019952783,0.010954896,0.07996027,-0.034682035,0.0018930667,-0.014739427,0.046375345,-0.025664458,0.0070481724,0.030750271,-0.003961243,-0.034847006,-0.03231058,-0.1403087,0.02836275,-0.040099334,-0.05604025,0.028274387,-0.09846558,0.024082532,0.09540894,0.088665076,0.030911691 +4.2.1.49,Contains tightly bound NAD+.,384,1.0,-0.05335761,0.023662927,-0.05214964,-0.020950906,-0.00083165604,0.035950664,0.033694703,0.05210144,-5.083412e-06,0.017052744,-0.016323341,0.023619218,-0.029664595,0.032841735,-0.033921514,-0.0022588393,0.0041934378,-0.027800174,-0.0380449,0.062620476,0.031603318,0.038590785,0.083510235,-0.013846657,0.034781363,0.0597236,-0.00037400625,0.00858085,0.14402533,-0.079813235,-0.07351093,-0.012439526,-0.02857504,0.006417006,0.008213407,0.072314,-0.062064342,-0.009065511,-0.00053498836,0.04025313,0.008542887,0.013055124,-0.01565239,0.09172784,-0.0020733224,-0.043166853,0.010771234,0.054787528,-0.00045105178,-0.03431822,-0.08884433,-0.030083593,-0.030589677,0.03863107,0.027159072,-0.031017795,0.0045316913,-0.035969246,-0.043352146,-0.0038723117,0.039441835,-0.044846397,-0.043529514,0.035043083,0.06078966,-0.016328095,0.08234169,0.028884597,-0.0493497,0.042939678,-0.05349956,0.037974916,-0.052201137,0.11430921,0.0075873695,0.102536164,-0.06534935,-0.097537726,0.0976811,0.01920905,-0.012102981,0.009290083,-0.07070185,0.053915907,0.06801501,0.0131764,0.006681019,-0.058023814,-0.027830953,-0.03375463,-0.013651821,-0.03623898,-0.022513533,0.08099195,-0.107674085,-0.029967101,0.048387,0.03700067,-0.07657876,0.025670901,0.023697099,0.1195881,-0.014698327,-0.031052453,-0.06998274,-0.0011937387,0.04791239,0.06607503,-0.019842716,0.02312452,-0.01847868,-0.013265457,0.042528152,-0.028515302,-0.061192833,0.02007775,0.028639674,0.057671573,-0.052169286,-0.036923677,-0.056016415,0.002709323,-0.014805792,0.023655748,0.018183168,-0.022308081,-0.052612085,-1.34003895e-33,0.10621353,-0.01830808,0.0022813058,0.07934455,-0.0275365,0.04205645,-0.063046895,-0.024820685,-0.08645919,0.04150026,-0.07723046,-0.08096,0.004242123,0.027353374,0.072467215,0.034130353,-0.010662293,-0.021399565,-0.020034423,-0.05575705,0.011183129,0.057429638,-0.033698495,-0.045058664,-0.00993265,-0.02643192,0.017379126,-0.008021515,-0.015795682,0.03661792,0.010968682,-0.059761733,-0.06726038,0.076442115,0.03232498,0.04190318,-0.09898581,-0.054415043,-0.0014162993,0.0012042725,-0.06543027,0.055258162,0.034657,-0.043708704,0.060288895,-0.14661619,0.025481164,0.06316926,-0.08105896,-0.004552416,0.057475027,0.014485448,0.023830784,0.00200484,-0.025135782,0.0037412453,0.051299535,0.06491943,-0.027485922,0.17723304,0.01570974,-0.007863192,-0.020078724,0.09111419,-0.0709828,0.06681655,-0.13478233,-0.10617683,0.08828443,0.06791851,-0.014247442,0.011121167,0.05676859,-0.0073031094,0.0023306622,-0.046461478,0.06900278,-0.03548739,0.0190344,0.01155028,-0.033476457,-0.07971738,-0.0123697715,-0.012758399,-0.12606834,-0.05319278,0.047320187,-0.07932474,0.0027862934,0.02913041,0.011192693,-0.042609237,0.0005119157,-0.11849887,-0.010950085,4.0448706e-34,0.06903526,-0.024165144,0.037790414,-0.04686416,0.018605422,0.029014576,0.018032763,-0.033404905,-0.049082693,-0.0981302,0.068631336,0.07739591,0.022702498,-0.045878205,0.008353074,0.013887195,0.02691861,0.033413053,0.006495496,0.008309226,0.030752616,0.07626618,0.05724914,0.08054375,0.057667624,-0.012844361,-0.09515279,0.059080698,-0.031989075,0.043252993,-0.007816326,-0.07793762,-0.17548172,-0.042188607,-0.054042466,-0.068221755,0.039891575,-0.011426405,-0.0591289,0.057654787,0.018870384,-0.011277013,-0.0823224,0.10071341,0.049552448,0.01657242,-0.00412727,-0.018544644,0.033295542,-0.020464193,0.03715472,0.013926316,0.008191338,0.0531058,0.10329608,0.00492328,-0.082378194,0.03289456,0.020255012,-0.0043811845,-0.024926974,0.014876259,-0.0047800187,-0.040084083,0.12264344,-0.0040562954,-0.032504097,0.03319926,0.027404457,-0.02732901,0.051305253,0.023835866,0.013162688,0.011574368,-0.012809781,-0.005207158,-0.043251753,-0.020687269,0.0041462756,0.004016614,-0.04142195,-0.0040746615,-0.055840593,-0.043813393,0.08674911,0.03486608,0.036916066,-0.022058528,-0.05595937,0.004926086,0.021015171,0.027755339,-0.01355635,0.013796392,-0.0067945044,-1.4950164e-08,0.07842291,-0.017787777,-0.010692421,-0.036831595,0.059992947,0.025574341,0.028371235,-0.0129714105,0.054581348,0.11161919,0.06890422,0.09501705,0.003883375,0.06112654,0.03378173,-0.01809179,-0.10690909,0.04800111,-0.098053336,-0.06363246,-0.05675566,0.014788035,-0.047278184,0.039005645,-0.008313743,-0.053284127,0.007909713,-0.06692174,0.054468002,0.01970206,0.048944484,0.0005184106,0.081868514,-0.046163384,-0.050527383,0.10697199,-0.0023122581,0.044797394,-0.039259493,0.061769098,-0.01505118,-0.055269923,0.0068984884,0.042197686,0.008506304,0.027610872,0.031621136,0.018093536,-0.059243955,-0.004497022,0.024328016,0.03299385,0.017485086,-0.050309617,-0.07241441,-0.017695453,-0.039955717,-0.044003487,0.0061850343,-0.060301464,0.011197482,-0.06371237,0.12057287,0.030018967 +4.2.1.50,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +4.2.1.51,"This enzyme in the enteric bacteria also possesses chorismate mutase (EC 5.4.99.5) activity, and converts chorismate into prephenate.",384,1.0,-0.04265593,-0.07329465,-0.011661831,-0.0032330225,0.015641809,-0.01778705,-0.00021080762,0.031295143,-0.011570415,0.015064154,0.0395874,-0.052606042,-0.011262804,0.022757346,-0.06938367,0.017900292,-0.012062056,0.0008135914,-0.0015945934,-0.01661616,0.021886418,-0.021496076,-0.0040878775,0.01665139,0.031028625,-0.06270672,0.08252084,-0.027710527,-0.081114344,-0.05848932,-0.07853997,0.0078462325,0.18341076,-0.04538334,-0.01035607,0.054518197,0.0049219434,-0.042172726,0.098375514,-0.0044217706,0.06830384,-0.035478853,0.016307883,0.0024930418,0.01537052,-0.008439191,0.020956203,-0.019934546,0.032495756,-0.015944742,-0.12842956,0.0053466507,-0.005901092,-0.0081794,-0.031824023,0.059694584,-0.078532375,-0.075413935,-0.0008658778,-0.058529686,-0.017529259,-0.0025842565,0.03880483,-0.027671691,-0.040100086,-0.041960407,0.0317713,-0.04363298,-0.009251611,-0.02166893,-0.0140068205,-0.052868467,-0.015164704,0.032614417,-0.015207272,0.047683667,-0.005754796,-0.03380868,0.03587725,-0.020240206,-0.0065953406,-0.009581172,-0.05015008,0.037051085,0.08970353,0.044913173,0.06394034,0.0026992527,0.018110627,-0.003341705,-0.018751878,-0.023995718,-0.037988167,-0.06057034,-0.076475225,0.019363433,-0.008245868,0.03887025,0.020606264,-0.02535344,-0.015615552,0.06005234,-0.00845303,-0.08763584,-0.088602744,-0.042066976,0.059595473,0.08763355,0.049273055,-0.00869044,-0.0044735568,-0.037017055,0.07826684,0.002442664,-0.059852656,0.1481922,-0.0052211457,-0.043481115,0.052505083,0.08482417,0.021285217,-0.019753026,0.009006454,0.06030269,-0.07305682,-0.051750228,0.0046669967,5.954266e-34,0.011729705,-0.010367819,0.018969005,-0.00017987647,-0.03710861,-0.026093015,-0.087089665,-0.022612259,-0.04556046,-0.08647388,-0.023561575,-0.072958104,0.004956628,0.078099184,-0.017020563,0.033763584,0.045961108,-0.0040729237,0.035479087,0.04063484,-0.0038355733,0.006240849,-0.06678101,-0.0006570708,0.114274584,0.003641072,-0.022703564,-0.025176877,0.0735686,0.007976499,0.05846558,-0.054238107,-0.02395567,0.021266103,-0.029190626,0.10447732,-0.05955266,-0.0053663054,-0.074341826,0.04911896,-0.0021133907,0.019542709,0.020749733,0.0044471924,0.02446366,-0.062880374,-0.07759177,0.102990195,0.08339543,0.05881535,0.031152459,-0.0037663346,0.07469279,-0.004192051,-0.05874362,0.018807985,0.04561134,-0.009740555,0.008820309,0.052899316,-0.007969909,0.02832275,-0.09003766,0.03827044,-0.028691206,0.038444124,-0.08314791,-0.06856341,0.032880247,0.083157234,-0.1428268,-0.0772713,-0.07479552,0.08846346,-0.026296586,-0.04005983,-0.053207524,-0.046712216,0.04430898,-0.032305047,-0.04998932,-0.03982942,-0.0020402065,0.0325533,-0.041000526,0.024960408,-0.043232694,0.038158152,0.057907294,0.03333896,0.101780556,-0.07267499,-0.10646034,0.062351026,-0.056656048,-1.5348486e-33,0.05477748,-0.08084161,0.04304658,0.008513526,-0.078932606,0.12207274,0.038424995,-0.03266912,0.06748409,-0.027983451,0.10770536,-0.029867573,0.020114997,-0.099544585,0.027676415,0.050210625,0.07067305,0.06840108,-0.03222034,-0.0038997412,-0.016764859,0.06664596,0.06257641,-0.018463546,0.0363547,0.043405913,-0.013269271,0.10445904,-0.013909986,0.057390727,-0.088410944,0.012043319,-0.025773235,-0.023570577,-0.051803514,-0.00796406,0.007979219,-0.020662623,-0.010404325,-0.030126669,-0.02259669,0.04771898,0.020497778,0.12264505,-0.011919659,0.093888946,-0.014661068,0.067465715,0.0012413698,-0.008674818,0.03420324,-0.014483705,0.031879418,-0.06628751,0.05631734,0.047334824,-0.033302654,-0.034915645,-0.02218025,-0.10760855,-0.0557059,0.0040479316,0.08420224,-0.0046752454,0.041239824,0.03660054,-0.054028094,0.058957398,-0.011255344,-0.09014358,0.028058836,0.038604017,-0.014440591,0.03311395,-0.016594118,-0.027020816,-0.084111415,-0.014962038,0.05432046,-0.0027014199,-0.0113352295,-0.026565231,-0.0050794347,-0.015994895,0.032629613,-0.0074546374,-0.011169755,0.05832238,0.044169776,0.0808724,-0.06536574,0.028895145,-0.066289335,-0.018399814,0.031094162,-2.970825e-08,0.063066415,-0.09674873,-0.023304228,-0.016326733,-0.009092754,0.011394445,-0.018790318,-0.009340126,0.07601813,-0.023630684,-0.06949261,0.12550884,0.031284664,-0.060434833,-0.04227601,0.07102754,0.0018924495,0.0024395313,-0.042757344,0.023436252,-0.047880247,-0.007717912,-0.09018103,0.058006965,0.07471426,-0.0071348795,-0.013325523,0.106086686,-0.034884512,-0.04207037,0.012147675,-0.027668402,0.045968685,0.014157099,-0.041981217,0.030993836,0.008542344,-0.037044838,-0.029395644,0.0601726,0.067647025,-0.047081687,-0.08154808,-0.050076686,-0.0283741,0.001574512,-0.049725223,0.030545237,-0.018149292,-0.0536248,0.0065452587,0.0117855705,0.031533197,0.0019188942,-0.08319678,-0.010494318,0.067542195,-0.08867327,-0.010578234,-0.016103948,0.0015978754,0.059466463,0.20766118,-0.014495635 +4.2.1.53,Acts on a number of 10-hydroxy acids.,384,0.99999994,-0.04568177,-0.11456963,-0.0024164498,-0.03232194,0.059673123,0.10959289,0.04406905,0.063427016,0.009201894,-0.06363081,0.04570661,0.0020442172,-0.03372426,0.048607595,-0.01863515,0.047957737,-0.025300391,-0.0021679918,-0.10393357,-0.028245829,0.032240413,-0.01907649,0.009124331,0.014702511,-0.05622773,0.010654468,0.07798211,-0.011606244,-0.015609099,-0.08132068,0.06889394,0.0072595077,-0.004725501,0.049025945,-0.03479807,0.003887815,-0.052337434,-0.081654996,0.033693887,0.073887214,0.084627554,-0.116515175,0.07247785,-0.09890621,-0.0124539295,-0.07043038,0.027781164,0.035037827,0.033465378,0.028821032,-0.021632025,-0.061212093,-0.067784876,0.039494336,-0.020776877,-0.058782462,-0.090038836,0.006968308,-0.023282625,-0.005441712,0.03882947,0.022068739,-0.015594654,0.078067556,-0.06336262,0.013493226,-0.0079516135,-0.057489682,-0.004924002,-0.007213854,0.018192137,-0.053043865,0.039937083,-0.04074001,-0.030038172,0.0031526198,-0.043852754,-0.095786996,0.017379556,-0.02408104,-0.029507114,0.020362774,-0.036913253,0.07648559,-0.03796852,-0.06684187,0.0038520782,0.027275708,-0.05580807,0.060428258,-0.022011327,0.01869661,0.030584764,0.015157305,-0.07389151,0.031571023,0.035200592,-0.01693694,-0.030740632,0.017065307,-0.05427008,0.10903684,-0.026897421,-0.06397158,-0.02940613,0.00026157816,0.0062964717,0.037662834,-0.03811438,-0.042160988,-0.018125782,0.0041543623,-0.017198058,0.027590435,-0.020141706,0.022185996,0.06838731,-0.07237105,-0.08826876,-0.08285092,0.01470601,-0.1134117,0.037368223,0.012704423,-0.08480106,0.04360313,-0.0037880442,-3.38659e-33,0.08369011,-0.08851206,0.026728887,0.02082463,-0.00035782202,-0.006734239,-0.11374558,0.045361504,0.01572804,-0.025634462,-0.02850045,0.02750679,0.04121912,0.07198969,-0.02601363,-0.040405344,-0.015703412,0.052533694,0.034204446,-0.018977534,-0.05237697,0.04562444,-0.06003854,-0.032293692,-0.093279004,0.059119772,-0.044211652,0.017290222,0.025779702,-0.008481217,0.0504943,0.022674229,-0.06815871,0.0903632,0.017364416,0.07713773,9.191777e-05,-0.0009549495,0.111765005,-0.04736233,0.0009284395,-0.022543345,0.0153488405,-0.041650735,0.08514926,-0.016194591,0.0300894,0.05300857,0.0022861606,0.025665745,0.04478114,0.015024191,0.067417435,0.035960667,0.025704993,-0.031709716,-0.0069008027,0.039709546,-0.022453833,0.076878205,0.060950197,0.012839839,-0.061844505,0.063909955,-0.047980357,0.029907122,-0.05632404,-0.010397651,0.086901434,0.032188512,-0.030182762,0.047051813,0.080664545,-0.019893866,0.06541578,0.02140009,0.041429415,-0.029139934,0.0015948117,0.10212721,0.034295008,-0.015814437,0.047175564,0.03719919,-0.08727118,0.07539678,-0.015966414,-0.053341083,-0.037328754,0.007816963,0.0070333197,-0.120682955,0.03311944,-0.032126155,0.0055699083,5.366364e-34,0.02572964,-0.0840636,-0.05471791,-0.010018926,0.011372483,0.016590007,0.083599225,0.018213287,-0.0014222065,0.027034579,0.06465115,0.05357247,0.03567881,-0.10592071,0.030831842,0.018113373,-0.003605291,0.05135262,-0.044370778,-0.0127329575,0.018286726,0.10128954,0.028831968,0.05801471,0.02702269,0.06331569,0.034516864,-0.02451579,0.042340238,0.11148826,-0.028749209,-0.018351082,-0.06676837,0.021403886,0.016278887,0.020159934,-0.011247868,-0.015027436,-0.024788417,-0.061683673,0.023256779,-0.07728746,0.036041077,0.016357496,0.061543986,0.116989255,-0.06414974,0.00610726,-0.099837855,0.014448566,0.0009977751,0.011335127,-0.031646598,0.010914506,0.030466465,0.08019506,-0.044352382,0.010125809,0.007635895,-0.08650998,-0.111497894,0.016609183,0.014344909,-0.10621819,-0.05834219,0.022636045,-0.03786799,0.03483838,0.019665174,-0.027543271,0.08676856,0.04522013,0.015753884,-0.0096367095,-0.026303256,-0.09014124,-0.029238855,-0.10941921,-0.01073099,0.017140223,-0.032149296,0.011473141,-0.013553319,-0.07825009,0.05100196,-0.052143954,-0.03053438,0.055027146,0.026817963,0.0843261,0.019330526,0.017742984,-0.029611655,-0.007063628,0.040076986,-1.8709601e-08,0.011611702,-0.08651442,0.116248436,-0.023632955,-0.02233378,0.011483785,-0.0023393405,0.071488485,0.04224937,-0.026519554,0.082702704,0.03267263,-0.009716617,0.10830634,-0.018822718,-0.08633817,-0.049070384,0.0006822993,-0.052953716,-0.032294013,-0.15490837,0.0009744878,0.010837815,0.006193426,-0.0046581174,-0.019750947,-0.005769531,-0.010293689,-0.026679756,-0.0031682965,0.07092014,-0.0028595477,-0.07631211,0.022950424,-0.029457591,0.07074657,0.028075954,0.0337626,-0.00081090414,-0.010918864,-0.047296483,-0.06450753,-0.08554157,0.056677856,0.035545073,0.001119215,-0.1255109,0.03300223,-0.006782636,0.048514288,0.051911633,0.02157288,-0.039795525,0.0070032133,-0.07282694,-0.023392983,0.01598397,-0.13536495,0.0019669172,0.022653794,0.025825694,0.115035556,0.12813829,-0.012683441 +4.2.1.54,A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway).,384,1.0,-0.10224142,-0.0073552527,-0.101628944,0.019368943,-0.006552673,0.042882405,-0.0080511775,0.037225954,-0.05843899,0.006408393,0.025921697,-0.093070604,-0.08097199,0.05606983,-0.06753341,0.06980152,-0.006629477,-0.039024144,0.034864713,-0.053693663,0.041031506,0.08675718,-0.057072967,0.020396665,0.057898797,-0.0071799317,0.03260603,-0.02076677,-0.024337294,0.0033515769,-0.003295794,0.0043428787,0.095941275,-0.037172448,0.13035902,0.061321005,-0.0318755,-0.03692807,0.08910516,0.054577537,0.043370597,0.027218359,0.015322467,-0.019522399,-0.037961524,0.035955306,0.054501988,0.03480184,-0.0252412,-4.3521308e-05,-0.12734152,-0.020811617,-0.057551462,0.009666165,0.01895288,0.0073110806,0.037639175,-0.068484545,-0.0644957,0.0029008829,0.03236959,-0.036159907,-0.08824845,0.019382043,-0.04465331,-0.05821664,0.0052066455,-0.0023772072,0.08689324,-0.020331992,-0.019440673,-0.06811041,0.07486261,0.050835248,0.07327333,-0.11725919,0.04351651,-0.07140364,0.03277686,-0.04191253,0.0036358312,0.040004987,-0.017143153,-0.029102394,-0.02195825,-0.03310325,0.06449666,0.01322101,0.046261013,0.025575196,-0.03185312,-0.04798315,-0.030856121,-0.12073971,-0.017987449,0.034781292,0.03530738,-0.0599769,0.055179544,-0.029371714,-0.057022277,0.06946243,-0.004345699,-0.07531693,-0.024630947,-0.0148296915,-0.020639192,0.09994792,0.073328435,0.06310263,-0.0030360415,0.044130776,0.031449407,0.0001839695,-0.012527114,0.02904385,0.012052652,-0.0736973,-0.0070828074,0.017928934,-0.022390772,-0.030795336,0.033045724,0.06518254,-0.064458914,-0.026254287,-0.0802593,-2.4932055e-33,0.04952758,-0.04219451,-0.017498888,-0.04175586,0.053134482,-0.03399243,-0.06067993,-0.051230952,-0.020868987,-0.055347174,0.01594353,-0.07267838,-0.020581739,0.07746477,-0.019384928,-0.032919217,-0.056397438,0.09126382,0.0035639887,-0.014102295,0.011765238,0.06502556,-0.016183602,-0.0029034566,0.006623162,0.014377353,0.027052725,0.018435974,-0.02610191,-0.013802262,0.06409885,-0.005455226,-0.054921094,0.00073790085,0.0936671,0.014192154,-0.05149801,-0.0942519,0.0048708916,0.049344044,-0.03519517,0.05125993,0.009463966,-0.013729718,-0.0009014675,-0.025588347,-0.10155837,0.14529599,0.0145770395,0.055929214,0.051000845,0.011671996,0.13121164,-0.021525022,-0.05554177,0.029002147,-0.028559448,-0.0015805331,0.037931483,-0.08827912,-0.05697071,0.062464166,-0.08801874,0.08347971,-0.029795706,0.012517843,-0.043445338,-0.012594387,0.10180386,0.0740609,-0.09911414,-0.029765787,0.004668265,-0.0023954734,-0.0058781537,-0.039054826,-0.072194375,-0.030039007,-0.05223443,-0.0060687508,-0.072114445,-0.044116173,-0.022975665,-0.026852746,-0.10838264,-0.023317773,-0.0265029,0.043233734,0.028256346,-0.013376354,0.056676153,-0.022893114,-0.034663904,0.08043268,0.023421638,4.04409e-34,0.11221193,-0.13765277,0.05152132,0.0025154965,-0.039134063,-0.013610474,0.013617881,0.026546767,-0.054900166,-0.057522092,0.039909746,0.019713074,0.056559563,-0.009007547,0.021584248,0.061450895,0.0346448,0.07371958,0.009514909,0.026646942,0.004897687,0.051757835,-0.01617523,-0.029203111,-0.007375779,-0.0072825374,-0.034121048,0.08759018,-0.016952593,0.026069306,-0.020659681,-0.032705832,-0.023818992,-0.094855145,-0.009082923,0.04368237,-0.0023374597,-0.028365407,-0.021497129,-0.0017572338,0.08044945,0.056100823,-0.04226239,0.11405316,-0.0018098884,0.064304344,-0.0072645457,0.026393475,0.010080739,-0.026044998,0.007551726,-0.06398698,-0.027827477,-0.061741445,0.008015263,0.024874298,-0.026952796,-0.0057358225,-0.011534406,-0.036509953,0.0034205087,-0.071853325,0.094161965,0.043739084,0.056062777,0.032352697,-0.036684386,0.047588225,0.03733062,0.023411011,0.15974839,0.09147023,0.027071096,0.06944864,-0.014396139,-0.060773846,-0.055447638,-0.06699346,-0.096781865,0.021836767,0.0059027295,-0.0032302726,0.02086785,0.065581284,-0.03410393,-0.0044206213,0.03504544,0.066972725,0.0005751224,0.048982844,-0.03736564,0.0070534693,-0.03811971,0.08346411,0.013280111,-2.2313e-08,-0.022757715,-0.06817119,0.114803895,-0.014798642,0.007925904,0.025448514,0.062281232,0.011124566,0.0587216,-0.056109194,-0.058192987,0.081555575,0.037002847,0.024261417,0.005858487,-0.019644752,-0.025395751,0.0050065047,-0.04014785,-0.062033433,-0.094926365,-0.022974215,-0.03438122,0.059437133,0.016899591,0.021094603,-0.012822051,0.10260156,-0.028727753,-0.062173877,0.0009670773,0.015733168,0.01538575,-0.019680057,-0.08343716,0.07372581,0.03305905,-0.079274125,-0.058538653,-0.070510864,0.023217406,-0.0050880243,-0.018122436,0.039442044,-0.024229642,-0.0053510945,0.014838812,0.015474113,-0.043711025,0.005360906,0.07385276,0.0281333,0.005578161,-0.00489616,-0.07329868,-0.032700177,-0.019820714,-0.02416768,-0.0073893713,-0.0017625048,0.054752484,0.02799408,0.18805227,-0.058086786 +4.2.1.55,Also acts on crotonoyl thioesters of pantetheine and acyl-carrier protein.,384,1.0,-0.06891029,-0.072285876,-0.00783095,0.018819068,0.029605681,0.08008706,0.047853433,0.06795325,0.013403676,-0.021142922,-0.0036740785,-0.039380427,-0.049889054,0.015451064,-0.010683005,0.08388217,-0.013139008,-0.019413203,-0.010549014,-0.06752437,-0.0043264893,0.012439742,-0.038920324,0.033250444,0.01363705,-0.03442596,-0.01645778,-0.015401746,-0.025380148,-0.0074658985,-0.0586952,0.020994708,-0.02412815,0.033693545,0.040308718,0.034019887,-0.044581562,-0.080369964,0.04421636,0.012868603,0.0777962,0.018344784,-0.063031085,-0.00023007723,-0.017456157,-0.027162597,-0.0072324644,0.035843864,-0.008016958,0.06174556,-0.0859965,-0.027207477,-0.018946148,0.04492509,-0.022186952,0.09110319,-0.019674193,0.009801487,-0.036993496,0.01485538,-0.051239267,-0.02394372,-0.07208527,0.008704714,0.013786213,-0.037488822,0.0063436856,0.07302324,0.06999816,0.00059446314,0.050322086,-0.0590603,0.02428653,0.09904595,0.041435994,-0.038813513,-0.04674845,-0.040909324,0.012815319,-0.021187639,-0.08821213,0.034640525,0.09831595,0.06096244,0.059312787,0.012082101,0.010881317,0.021692688,-0.04510254,0.00066695944,0.036099963,-0.03412882,-0.057015445,-0.0068534072,-0.08278661,0.010036681,0.08072481,-0.088397115,-0.001993323,0.006411675,0.06512531,-0.008302031,0.02308653,-0.0015752264,-0.1131329,0.036625847,0.020462055,0.029010102,-0.0765865,-0.03523938,-0.012880189,-0.011444627,0.0873298,-0.06212717,-0.090638444,0.05406142,-0.052793175,-0.04304489,0.037963454,-0.027067583,-0.006307617,-0.039716512,0.014939497,0.054801956,-0.062429246,-0.0318771,-0.049958035,1.7252192e-33,0.022232091,0.02640396,0.016797712,0.038194723,-0.009245502,0.008679558,-0.07749194,0.044303585,-0.035611596,-0.048939716,-0.033334896,-0.10648731,0.030303063,-0.0020915412,0.032407172,-0.05092877,-0.060745157,0.020357678,0.055949457,-0.018040175,-0.019944312,0.06862035,-0.045343406,0.023721645,-0.061497185,-0.0269758,-0.006029695,0.055750746,-0.056083426,0.0193303,0.05594943,0.043792505,0.025220735,0.018589292,0.0008489513,0.09415917,-0.0421336,-0.029716924,-0.03816677,0.13025536,0.0825185,0.009185792,-0.033976603,-0.057419736,-0.01107313,-0.08948488,-0.07912798,0.04226987,0.017786691,0.010437468,0.068173036,-0.07074652,0.09181924,0.022209037,-0.054744218,0.08575827,-0.054845136,-0.10256005,0.079483554,0.0039480776,0.040088188,-0.05943127,-0.015438102,-0.006971633,-0.0031517744,0.047392387,-0.07842637,-0.01801571,-0.064028166,0.08803221,-0.03650791,0.014818253,0.10138243,0.022558307,0.090046115,-0.05806344,-0.07181643,0.07473172,-0.039017905,0.026380422,0.11145106,-0.06980414,0.063766085,-0.0052764257,-0.08729197,-0.08534137,0.039376948,-0.020294921,0.012932743,0.05940864,0.12705569,-0.074952215,0.011224989,0.030107064,-0.043676145,-1.6521652e-33,0.007632793,-0.10371173,0.029820947,-0.036916457,-0.071045265,0.08948027,0.019351551,0.0066658757,0.019478906,0.051751222,0.15166445,0.031691767,-0.037005074,-0.0955834,-0.04354552,0.07797647,0.028244933,-0.0025389562,-0.01208313,-0.025740713,-0.07741812,-0.08059532,-0.010903507,-0.0034531783,0.03436714,0.059369396,-0.041110788,0.03358314,0.062175214,0.01477256,0.05649831,-0.038028985,-0.057722952,-0.03169322,-0.016056288,0.030063633,-0.02538379,0.047435433,-0.036864538,0.007819454,0.03220815,-0.020899573,0.110096954,0.0904618,0.0369407,0.006676017,-0.091299675,-0.07195575,-0.04419623,-0.07162268,0.03639118,0.0036262884,0.036118302,-0.015642855,0.024518447,0.0699804,-0.007514469,-0.07581195,0.051984034,-0.012568167,-0.046151567,0.012888414,-0.007783471,0.024966288,0.07485799,-0.023802247,-0.15526088,0.091549896,0.020015938,0.0516962,0.028276753,0.031716283,0.014841655,-0.018582625,-0.04599412,-0.04564184,-0.042886153,0.001777594,-0.034324095,0.025977558,0.029808268,-0.082970515,-0.0005946164,-0.05567326,-0.098561324,0.015017103,-0.014423198,0.070918664,0.00238873,0.020861391,-0.06151383,-0.020787079,0.031716723,0.0333065,0.11355191,-2.3602075e-08,0.0279587,-0.13389653,-0.03542716,-0.0030668878,-0.071833685,0.024726791,0.058041032,0.005587414,0.025834212,-0.015689474,-0.112023264,0.033866003,0.04530186,-5.2434207e-06,-0.015059983,0.06754012,0.0034180917,-0.028526451,0.0028221374,-0.03025422,-0.0755368,0.019636812,-0.0009577686,0.04800456,-0.0134364795,0.00996042,0.036501326,0.109224185,0.036774725,-0.0019671721,-0.051716127,0.031263843,-0.017921286,-0.0020866317,-0.046100434,0.07230248,-0.0065630483,-0.059015352,-0.04905183,0.020532584,0.05237753,0.0050763865,-0.044991586,0.023671096,0.08492986,-0.037201777,0.064911544,0.018850934,-0.009314192,-0.021976076,-0.00038445494,0.038392566,-0.0017585594,0.010744332,-0.07098214,-0.00812522,-0.005323152,-0.04682946,0.036317106,-0.05066426,-0.023656178,-0.007981091,0.14744069,0.06650736 +4.2.1.57,Also acts on dimethylacryloyl-CoA and farnesoyl-CoA.,384,1.0,-0.08312071,-0.061955675,-0.038721293,0.015658043,0.025351102,0.015741913,-0.073381685,0.05673882,0.08116063,-0.051597215,0.03509019,-0.029587155,-0.059084456,0.07057797,0.013054584,0.0064801755,-0.05219909,0.056336273,-0.029797567,0.034128625,0.035114117,0.04093751,0.022769714,0.00968795,-0.0062591136,0.02260715,0.02107263,0.03705505,0.073680624,-0.097051494,-0.005984137,0.09363108,0.02702631,-0.029037574,0.02574846,0.066994764,-0.02666916,-0.012451876,0.006757531,0.053421702,0.078623615,-0.12670864,0.007820701,-0.006258379,-0.05657408,-0.054131728,-0.053449947,0.014416768,0.016693667,0.09547861,-0.046650175,-0.07553991,-0.08171589,0.07291828,-0.050097127,0.012073388,-0.07670781,0.042383384,0.018752199,0.0100815445,0.0016134715,-0.0064681177,-0.023877164,0.03204648,-0.045878492,0.025341501,0.045525245,-0.06391682,0.009859158,-0.06431897,-0.014392444,-0.04522197,0.004863875,0.052000068,-0.0008989069,-0.015401678,0.007463048,-0.050275587,0.017412528,-0.03411603,-0.103629306,0.05362839,0.030720435,0.042135183,0.019038973,0.06218561,-0.04583714,-0.049406048,-0.030546004,-0.0068047903,0.04106242,-0.026830537,-0.03607218,-0.030589938,-0.05388123,0.041387178,0.021744333,-0.037746295,-0.051242314,-0.010087228,0.004508575,-0.016480057,-0.09238002,-0.03062977,-0.01584244,0.0018078074,-0.038307942,-0.026102519,-0.034469534,-0.051423788,-0.01616443,0.01119945,0.11202765,0.054783862,-0.03538759,-0.0063636038,-0.00067172607,0.020686539,-0.017441252,0.020171454,-0.025030656,-0.05935008,0.015588351,0.05486262,0.014165296,-0.0076182587,-0.016441856,1.0445087e-33,0.08768906,0.02068231,0.03174082,0.023326539,-0.0047512483,-0.04920067,-0.04115956,0.007463981,-0.0059012757,0.011811053,0.013441628,-0.02793277,0.05152277,0.046306275,-0.022299727,-0.004019811,-0.019751174,0.016318126,0.01746873,-0.0686954,0.028254252,0.119241595,0.011468905,0.028524803,-0.021163054,0.01353625,-0.032272615,0.07224166,0.05351882,0.030885223,0.030336825,-0.07523183,0.0032970365,0.022924196,-0.011057548,0.07718587,-0.11007039,-0.048873402,-0.017700082,0.099198304,0.032171633,-0.02103109,-0.11515076,0.009999245,0.045563575,-0.044117287,-0.015978368,0.089695096,0.014887188,-0.047893662,0.08550665,-0.04116126,0.044980552,-0.01730948,-0.06892945,0.06981092,-0.04314925,-0.06825104,-0.020310787,0.050806582,0.015047562,0.030039676,0.019528713,-0.003928176,0.02384529,-0.026559493,-0.08787904,-0.06611983,-0.0550584,-0.0015200261,0.029381096,-0.012401369,0.115571894,0.056346033,0.018465877,-0.006089001,0.010444438,0.017063396,0.057682537,0.04453607,0.030308126,-0.04241413,0.059382033,-0.06101382,-0.011231785,-0.031651154,0.012733524,-0.14890343,-0.02353897,0.040755045,0.048859477,-0.092082135,-0.01785404,-0.0686026,-0.006134727,-1.9643851e-33,0.031374298,-0.075838484,-0.0147677185,-0.047373172,-0.02870899,0.0018479076,-0.013435098,0.012533365,0.011311969,-0.012255648,0.11761932,0.007939814,-0.08775248,-0.069097355,0.020429224,0.0719652,0.11253761,0.032881394,-0.025408572,-0.017576039,-0.07339043,-0.00038855764,0.003997533,0.076448545,0.07721844,0.04453374,-0.031823095,-0.05967602,-0.044245567,0.12189644,-0.010872063,-0.009816123,-0.080328405,-0.061680127,-0.032655176,0.027213786,-0.04862051,0.0016002546,-0.03795617,-0.11249045,-0.05537315,-0.07048108,0.101251334,0.06310301,0.030615797,-0.000970272,-0.009807407,-0.07652459,-0.106013864,-0.025863575,-0.00043957986,0.06565641,-0.009774941,0.057645965,0.027866386,0.096582256,0.01734634,-0.06779035,0.028924942,-0.061815646,-0.016574604,-0.012112284,-0.015754411,-0.06489114,0.14202493,0.057085607,-0.0422124,0.038368717,0.07915935,-0.019376988,0.10518271,0.038348883,0.030554803,0.0044415784,-0.11238674,-0.044668254,0.020747911,-0.08074268,-0.049832053,-0.005353053,-0.06439865,-0.04258059,-0.038399234,-0.031601485,-0.11574274,-0.05892668,0.036414646,0.08682041,0.02224784,0.06805509,-0.06080134,0.0056274934,0.012511325,0.04734813,0.14425845,-2.5957046e-08,0.01395349,-0.06436576,-0.01190324,-0.041694067,0.023888828,0.02425337,0.009836205,0.029033633,0.004515989,0.023757663,-0.033057213,0.10998436,0.09724151,-0.031034226,0.10669444,-0.043692697,0.005494721,0.043997433,-0.03632556,-0.10700679,-0.04498364,0.003146255,0.007603821,0.017618781,-0.0027455234,-0.054534536,0.049824674,0.048314035,0.021939281,0.023736626,0.043315154,-0.026390208,-0.023726268,-0.04214169,0.001109444,0.029946912,0.08013997,-0.020254958,-0.019683633,0.07516382,-0.0010312108,0.032014932,-0.035032414,0.08133235,0.016577097,-0.029299982,0.02648053,0.05060426,0.026110915,-0.035668883,0.017883781,0.022172738,-0.034691498,0.00028954798,-0.10991889,0.056781363,-0.00024994786,-0.02835324,0.023604395,0.016418276,-0.037400298,0.037746515,0.15341058,-0.013876466 +4.2.1.58,Is specific for short chain-length 3-hydroxyacyl-[acyl-carrier protein] derivatives (C4 to C8).,384,1.0,-0.0304388,-0.029793872,-0.005028993,0.022588188,-0.024228066,0.063019514,-0.057667058,0.09816513,0.051074795,-0.09402659,0.11193821,-0.025856229,-0.055869214,0.03948346,-0.015695209,0.07593682,-0.035252333,0.03601636,-0.07301468,-0.03719759,-0.037324075,-0.01904429,-0.008198286,0.0639279,-0.04175962,-0.092322655,0.01766789,0.014439362,-0.03295372,-0.055293724,-0.009901719,0.04589968,0.0054354323,-0.0048711454,0.058096994,0.049469136,-0.05022769,-0.07336842,0.10811776,0.04356171,0.073880345,-0.049348336,0.01576005,0.11199574,-0.04413497,-0.0021365853,-0.05334052,0.04624195,0.047019657,0.05706832,0.040381987,-0.023235127,-0.053026088,0.08178826,-0.011792617,0.0018289168,-0.13235101,-0.02437471,0.056535833,0.08450879,0.0005008049,-0.0118491305,-0.016670667,0.05837801,-0.007040593,-0.0250013,0.04202824,-0.03703985,0.027985362,0.028154474,-0.045450814,-0.08989034,0.03496392,0.102398954,0.016470088,0.03876589,0.029386817,-0.061250214,0.016589856,-0.09965939,-0.028820554,-0.010683286,0.07471175,0.045890555,0.043617785,-0.06224965,-0.023358252,-0.035723485,-0.031785894,0.0027206256,0.022845838,-0.037602972,-0.025712319,-0.029463464,-0.08064463,0.028918317,0.0636193,-0.06164443,-0.050682712,-0.0037509722,-0.0027365428,0.022819685,-0.024595147,-0.009207604,-0.01828607,-0.034922365,0.0079041,0.060546488,-0.051233683,-0.046158448,-0.10704446,-0.0012296034,0.012408571,-0.0724787,-0.03841656,0.031122468,-0.098293185,-0.030791424,0.06873884,-0.043010022,-0.0063659716,-0.02621013,0.00575076,-0.01999885,-0.089473866,-0.013237652,-0.04109445,-1.4979853e-33,0.027844077,0.034122594,-0.002654644,0.059561614,0.018891612,-0.044276934,-0.059672438,-0.021551799,-0.062997356,-0.013519057,-0.044116583,-0.039619528,0.0015688088,-0.0114274165,0.027246382,-0.040320013,-0.0045460863,0.026007682,0.06026571,0.0034030196,-0.023657147,0.08942865,0.0234307,-0.030933447,0.03199349,-0.04986463,0.023168204,0.03266672,0.03234138,0.0023149606,-0.045647196,0.031528786,-0.042080577,-0.029587062,0.04512041,0.006383001,-0.020842262,-0.09004828,-0.005728017,0.08716196,0.050978716,0.0032914376,0.01653314,-0.07486831,-0.010560038,-0.012291854,-0.072598815,-0.0161584,-0.03159231,0.06183436,0.07660483,-0.0015759444,0.039956525,0.009081426,-0.020969644,-0.036948986,-0.122108,0.014312429,0.026187511,-0.021079592,0.014072338,0.086110905,-0.04896466,-0.037628196,-0.01157418,0.026061902,-0.08594573,-0.027657898,-0.05467974,0.044980593,0.034888856,-0.019635515,0.08368575,0.08680906,0.1544214,-0.014838169,-0.1271964,0.0568237,0.057833422,0.03536188,-0.072301336,0.015296212,0.042437855,0.08161391,-0.026084304,-0.06029331,0.052496668,0.00088607817,0.019198036,0.0071296506,0.036627904,-0.026227862,0.022742208,0.082127176,-0.005880427,-9.853318e-34,0.0056014196,-0.073854156,0.011372689,-0.07677456,-0.020505559,0.036368627,0.050869606,0.010259739,0.023422202,0.008239855,0.16283648,0.071117245,-0.10280744,-0.08558455,0.048169907,0.008708301,-0.09098273,-0.069610484,-0.021412663,0.021377767,0.016721549,-0.058718897,-0.066228636,0.09529309,0.04060661,-0.0042986292,0.023460612,0.017806254,0.023032112,0.0629034,-0.045024272,0.0036430475,-0.012420385,0.035156038,-0.0059540425,0.036331285,-0.065969035,0.02546364,-0.0025636542,0.019243848,0.030461406,0.0052727736,0.02436511,0.06928548,0.032857645,0.08838305,0.030653205,0.016016321,0.047170248,-0.0125481095,-0.0067051006,-0.02275579,0.028051155,-0.045703042,-0.0053492067,0.08609914,-0.00458802,-0.06809853,0.039995205,-0.069174305,-0.052432556,-0.01862958,0.07911671,-0.0187913,-0.008900523,0.0696382,-0.069645025,0.04325029,0.009380546,-0.03299686,0.05016765,0.012862812,-0.038214978,0.008270997,0.0212398,-0.123874806,-0.004452194,-0.049860388,-0.047296576,0.038562085,0.019085074,0.00071255834,0.010403901,-0.007818207,-0.040038176,-0.042994164,0.019926284,0.018365845,0.045554094,0.036814973,0.042075194,0.029581571,-0.027955467,0.0561788,0.026137237,-2.6257721e-08,0.02878678,-0.033751704,0.074231416,-0.07171319,-0.02294065,0.055312715,-0.041043703,-0.024157679,0.045171406,0.033646468,-0.045653056,0.12745881,-0.014227721,0.028021013,-0.061159883,-0.02569651,-0.02383917,-0.0029301865,0.009230751,0.012440967,-0.12146758,0.049110986,0.033452682,-0.0031417448,0.0068892334,-0.0032204587,0.038277112,0.0124186035,-0.026623998,-0.07449195,0.09886295,0.097230814,-0.021347674,0.012323574,0.0177636,0.03756343,0.0056883125,-0.021224378,-0.038339943,0.10630352,-0.011230011,-0.05100728,0.016554665,0.03907077,0.091623984,-0.049202953,-0.022249771,0.03161852,-0.023086673,-0.0232427,0.008141648,-0.010101766,-0.062267363,-0.09416551,-0.05075492,-0.076924965,-0.08505669,-0.055611953,-0.03882939,-0.1325336,-0.03745814,-0.0083306115,0.18827285,-0.024159335 +4.2.1.134,"This is the third component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.",384,0.99999994,-0.0801014,-0.100903355,-0.08191787,-0.012427206,0.09089294,-0.0056949425,-0.12961417,0.0034542675,0.021150513,-0.06882951,0.11806198,-0.055397194,-0.06651228,-0.003859036,0.011891715,-0.0023967593,-0.091701,0.037199367,-0.044663124,-0.09406389,0.077335306,0.07088762,-0.0056073377,0.051638212,0.030830022,-0.0616584,0.055332907,-0.023184283,-0.023394536,-0.131208,0.012041988,-0.007030629,0.10629908,-0.054613173,0.08305369,0.062069986,0.0135687385,-0.095488034,0.0086594755,-0.0340366,0.10297074,-0.043298542,0.07222492,-0.036573853,-0.029192828,-0.05583001,-0.029215818,0.0236483,0.008426429,0.030641552,-0.0074432627,-0.10340782,-0.06952448,0.06589475,0.03630213,0.020526998,-0.036724187,-0.004113994,0.006852796,0.0254749,0.0809443,-0.00792323,0.0015215137,0.0096575795,-0.008364957,-0.049093176,0.08673525,-0.04175049,-0.033836424,0.021304606,-0.00082840305,-0.0684429,-0.04652407,0.11528035,-0.011681766,0.050302118,4.4019744e-06,-0.026514214,0.01653441,0.034143195,-0.048340894,0.031411428,0.015601255,0.033533834,0.04647198,-0.009523413,-0.015319853,-0.03523964,-0.05217261,-0.01423856,0.012988763,-0.049080368,-0.015257307,-0.014295468,-0.021862423,0.07450902,0.016874721,-0.035728436,-0.034033254,-0.0191816,0.011531353,0.11297561,0.048376556,-0.03328232,-0.04056333,-0.0019974639,-0.07794397,0.11520642,-0.015467172,0.015057616,0.033492174,-0.031691547,0.086162716,-0.007744992,0.0075387084,0.046136044,-0.04585863,0.0008785959,-0.015550834,0.09003274,0.03123801,0.026956398,-0.014582839,0.043656908,0.026430493,-0.039316464,-0.09883327,-1.0511083e-34,0.034456704,0.029191392,0.028943323,0.05432043,0.024638267,-0.022179937,-0.07516696,0.053969253,-0.08876267,-0.0304686,0.024892807,-0.0015966396,0.088548265,0.06569246,-0.011310429,-0.037427593,-0.008440683,0.030814622,0.031887125,0.006278864,-0.037534755,0.030010361,0.013739915,-0.016463973,0.032400385,-0.060277674,-0.027974714,-0.008277381,0.02501381,0.017367559,-0.030838752,-0.029385557,-0.07680034,0.024144886,0.010013158,-0.06593862,0.016340384,-0.1159318,-0.030102082,0.11092809,0.08031424,0.012681538,-0.033378467,-0.04364008,0.025405103,-0.07113985,0.011488524,0.054382242,-0.012617261,0.033203326,0.070409745,-0.008094005,0.093081295,-0.03761875,-0.04204001,0.01798791,-0.10429897,-0.013504648,-0.014237172,0.01893946,0.031548824,0.026941637,-0.029441884,0.09077018,-0.031929173,0.013867597,-0.12050474,-0.03354374,0.022047164,0.016576469,0.034634136,-0.058261618,0.07231898,0.061867,0.039101515,-0.043135323,-0.108415544,0.07329712,0.008912264,0.014715074,-0.0426101,-0.041688293,-0.029018508,0.018685961,-0.018577524,-0.04094751,0.0021143951,-0.0051243906,0.053209595,0.04472703,0.03282874,-0.05597438,0.004919788,0.016300578,0.01240298,-2.557392e-34,0.104371324,-0.10703621,0.021895675,-0.15319541,-0.046048194,0.0093943905,0.03012649,0.056865774,-0.0070707463,-0.027452108,0.07958158,0.011633421,-0.01899605,-0.14281295,0.039688583,0.041850273,0.035311628,-0.022545036,0.043745093,-0.022124125,0.05922646,-0.021096146,0.07678551,0.050196104,0.04397605,0.06544019,-0.047642957,0.033801615,-0.021978566,0.06669665,-0.07249593,-0.03385114,0.0006021069,0.035869107,-0.07594158,0.045397636,-0.047179673,0.006572242,0.041277282,-0.026622027,-0.017782196,0.0810332,0.022634422,-0.0043965485,0.07928204,0.0013600106,0.018204657,0.035068743,-0.023656063,-0.094855376,0.0048779394,0.019811986,0.0054746866,0.019628026,-0.013154988,0.029786287,-0.01370575,0.01651726,0.056479786,-0.032659534,-0.060355294,-0.0026822046,-0.0006073889,-0.025078032,0.11159311,0.073227294,-0.009992761,0.0147968475,0.02570787,0.021975456,0.07273144,0.03432601,0.030980539,0.051581454,-0.013008683,-0.0692219,-0.054341964,-0.051790945,-0.0646457,-0.07551933,-0.060661465,-0.089900546,-0.03207848,-0.022431834,-0.031179126,-0.064468004,0.017855417,0.1042317,0.051192485,0.024516763,-0.041944943,0.008301654,-0.05155477,0.08485151,0.098151445,-4.469613e-08,0.06647931,-0.048883226,-0.026582262,-0.05502975,0.062762916,0.04096399,0.030943688,0.036344305,0.05594055,0.005120638,-0.0066156555,0.059347354,0.095405266,0.008355276,0.040390234,-0.013293222,0.033962816,0.012697073,0.00097061525,-0.045023546,-0.0114854975,0.01264908,-0.03484776,0.09057246,-0.06340394,-0.024321742,0.019987086,0.050299965,0.0088726785,-0.041044414,0.0073368317,0.04274187,0.011491101,0.045555092,-0.05380395,-0.01987956,0.022278657,-0.063875906,-0.078098066,0.06108657,-0.026308218,-0.005149941,-0.06169774,-0.0061235344,0.09136551,-0.057532094,0.010863969,0.049937706,-0.0068160337,-0.03402913,0.00014731237,-0.012940237,-0.038501635,-0.021559948,-0.073218256,-0.04119433,-0.022741068,-0.035510752,-0.012723399,0.028370278,0.012812653,-0.0015047682,0.167349,-0.047463465 +4.2.1.152,"Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase.",384,0.99999994,-0.006517415,-0.052270778,-0.017927472,0.001972255,0.047840003,-0.029202899,-0.027318675,0.01903225,0.0076646917,-0.044913374,-0.006724585,-0.035712853,-0.075162865,0.013452659,-0.06148947,0.024072887,-0.05388281,0.016571986,0.06544611,-0.015234928,0.06203487,-0.056427564,0.03031646,-7.13771e-05,-0.041579816,0.040907983,0.043127127,-0.032010566,-0.03201077,-0.104264066,-0.03584424,-0.13358346,0.051089995,-0.055616308,-0.019091718,0.07844281,-0.05949337,-0.08152172,-0.0005739984,-0.0038099021,0.00983026,-0.07491088,-0.040989127,-0.03862424,-0.0738622,-0.02936051,-0.017146675,-0.05240278,0.0013806955,0.039712857,-0.053048786,-0.08158346,-0.074542664,0.034682956,0.01653973,-0.06856446,-0.01451699,0.012176094,-0.013924801,-0.0011078535,0.0051426035,0.027523912,-0.029806003,0.01131103,0.02964737,-0.07015297,0.07749124,-0.053628158,-0.06708339,-0.065287165,-0.041944113,-0.028054565,0.03234355,-0.04123282,-0.04214593,0.002124337,-0.019948483,-0.059940174,0.08102577,0.031776957,-0.011975792,-0.0026355684,0.0077329786,0.050021127,0.031412266,0.004500587,-0.09345968,-0.0020832778,0.003307745,0.10473144,-0.0037957372,0.04221903,-0.027308267,-0.0018437061,0.004853461,0.041554455,0.05793474,0.12061849,0.043522775,-0.034780324,-0.048598062,0.08934019,-0.10693951,-0.12636691,-0.0077057783,0.042820986,-0.022024589,0.0010210165,0.07642314,0.052842706,-0.021718098,-0.03594984,0.04352545,0.050454777,0.031502474,0.078165606,0.0047387173,-0.06034045,-0.022156486,-0.011918171,-0.00042019543,0.001867833,0.036188934,0.037782773,-0.039980635,0.048550747,-0.082515664,3.4399152e-33,0.11358983,0.03867303,0.014044244,0.032924812,0.007861879,0.044530302,-0.06474518,0.03750424,-0.02765717,-0.008368456,-0.098604076,-0.06288062,0.05104111,-0.013523097,0.0111796735,-0.0640536,0.021684175,0.014760336,0.048563845,-0.00411987,0.034154844,-0.0030412492,-0.04692602,-0.0021741092,0.0069670766,0.059157025,-0.1274726,0.02315421,0.0009778135,-0.010947741,0.007904463,-0.113659956,-0.07931378,0.0057662437,0.022827817,-0.022617714,0.012563828,0.00025283208,-0.07499989,-0.00042197123,0.042972952,-0.010204114,0.012556976,-0.0958969,0.08094981,-0.031184465,-0.05209484,0.1069794,0.041976772,0.119419284,-0.008583562,-0.07675026,0.044931505,-0.040464208,-0.047550105,0.08048695,-0.025754146,-0.01784126,0.049595535,0.10360867,0.0081902165,0.09692279,0.07536959,-0.017645452,0.043134417,0.019345103,-0.04599366,0.04012455,-0.031826697,0.13661039,-0.009833366,-0.0030524211,0.09674897,0.01073548,0.09041727,-0.061467726,-0.052252997,-0.0025951103,0.051866602,0.005060259,0.047318883,0.04143094,0.037799723,-0.02546057,-0.021563388,0.037653796,-0.016341137,0.01495424,-0.011091056,0.12569007,0.009591358,-0.094229594,-0.04178371,-0.034113687,-0.007326213,-4.4794027e-33,0.1435882,-0.110010564,0.050600477,-0.08496978,-0.07116847,0.062082663,0.023534082,0.015722258,0.015843024,0.008035365,0.091391124,-0.019707961,0.0811396,-0.053762816,0.037926428,0.0006796923,-0.052736267,0.07248578,0.048263624,-0.014373734,0.020058664,0.024647517,-0.080908954,0.12247523,0.07918695,-0.036040273,-0.067832895,0.032301113,0.09618179,0.012147414,-0.029294917,-0.0065689343,-0.028109776,-0.055011455,0.0038973668,0.028066207,-0.05385729,0.034450077,0.06808564,0.07145683,0.025603889,0.005848616,-0.0006980163,0.08117796,0.022066707,0.09305864,-0.06938093,-0.047736984,0.015594765,-0.009325287,0.0067957225,-0.019821715,-0.115263164,0.040296268,0.038143545,0.050893527,-0.006714674,0.016205333,0.0037523364,-0.035222437,-0.0016371127,-0.034312934,0.002662812,0.06985171,0.043210063,0.021578938,-0.062235877,0.02864938,-0.04134521,0.011861822,0.021348437,-0.034867827,0.04089447,-0.057106942,0.009532671,-0.068519264,-0.01932671,-0.020862846,0.0052374136,-0.024232782,0.04233752,0.05855325,-0.0044449572,-0.12856825,-0.03514196,0.001505448,0.008925677,0.06641142,-0.01237087,-0.010102172,0.0024126132,-0.015907941,-0.03206095,-0.02075041,0.025856113,-4.5302656e-08,-0.043029957,-0.030561114,0.08750075,-0.03711888,-0.0077940454,0.07080259,0.030910822,0.01880497,0.02442442,-0.024398085,0.019652171,0.035307206,0.05443334,0.017971726,0.06741025,-0.04788676,0.02016932,0.03952238,-0.0045503606,0.04608545,-0.09581375,-0.021920528,-0.06427746,-0.005577628,0.05369228,-0.048820026,0.009449965,0.053158227,-0.014272957,-0.022307653,-0.058749814,0.049006388,-0.023432665,-0.02964124,-0.037210464,-0.0038919107,0.0043417956,-0.014001256,-0.08125332,0.027807707,-0.012881332,-0.1280609,-0.05942178,-0.017945208,0.04182489,0.028052248,0.018671926,-0.034868218,0.02058958,0.00021761892,0.0569596,-0.04100612,0.052256767,-0.06948652,-0.0014931923,0.03280673,0.02446902,-0.040966496,-0.01688464,-0.07587533,0.055279393,0.00388159,0.1766972,-0.022710692 +4.2.1.59,"This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyses EC 5.3.3.14, trans-2-decenoyl-[acyl-carrier protein] isomerase. Despite the differences both forms can catalyse all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates [4].",384,1.0,-0.091550685,-0.08783362,-0.078716785,-0.0052472623,0.057093196,0.007239521,-0.114111826,0.08501945,0.009362588,-0.03910315,0.025304921,-0.039442535,-0.093718424,-0.023275737,-0.0012306568,-0.026497819,-0.032879096,-0.008248401,-0.005898352,-0.027749415,0.08638466,-0.020915996,-0.04950756,-0.07780889,-0.0014094397,-0.0376068,0.028914561,-0.018838918,0.0119843045,-0.10526664,0.056396745,0.002537535,0.042550746,-0.046744913,0.047672167,0.024213545,0.014580699,-0.07097595,0.0985439,-0.065090165,0.078928314,-0.009660979,0.021031482,0.0038271681,0.030499132,-0.030824767,0.0053211646,0.0675987,-0.022129327,-0.055937406,-0.066134475,-0.053244665,-0.042889956,0.04828484,-0.041878812,-0.009305501,-0.005642282,0.0018724187,-0.06458996,0.0041244407,0.018779535,-0.021333994,-0.041863218,-0.019435013,0.008133486,-0.065957606,-0.0053403666,-0.05171117,0.08910627,0.041279003,-0.07440322,-0.06943896,0.008854425,0.06594009,-0.041638374,0.032929085,-0.05336084,0.01897693,0.04631414,-0.029143771,0.011092987,-0.017237606,0.036564104,0.066142395,0.034715123,-0.090185806,-0.008270535,0.027924798,0.015036164,0.064072855,0.087661035,-0.0030648264,-0.031640008,-0.01226684,-0.12326914,0.049341384,0.06701785,-0.019048173,0.008763504,-0.03603218,0.05443191,0.052425258,0.020592555,-0.036677383,-0.027706243,-0.010289263,-0.048843388,0.044251613,-0.024757508,0.026973186,-0.04668586,0.033904284,0.008645109,-0.02724231,-0.040437214,-0.02131944,-0.0049809627,-0.094017796,-0.008952581,-0.021190403,-0.05429172,-0.01539498,0.061031032,0.035466135,0.0011026544,-0.009189211,-0.109197415,2.4172353e-33,-0.012665974,0.024839452,-0.03291483,-0.087372534,0.06117482,-0.041759014,-0.08054395,0.048663877,-0.07803717,0.015396846,-0.02709949,-0.08652291,0.023143515,0.0053476286,0.011971715,-0.03070615,-0.0087507125,0.006316658,0.048697524,-0.052325252,0.051973127,0.07697796,0.0016796743,-0.039417032,0.027799109,0.0012839262,0.017326996,0.04293249,-0.020521436,0.013134443,0.0128909135,-0.07543054,-0.022420274,0.027002499,0.066606075,0.004025288,-0.034305777,-0.044943053,-0.037127037,0.018063975,0.0973062,0.017554883,0.021767773,-0.0073721283,0.058092225,-0.030486306,-0.051830724,0.059752353,0.015157669,0.031710863,0.075203635,-0.0426901,0.09566808,0.050399482,-0.06181689,0.006714118,-0.082386054,0.0031041903,0.010786371,-0.043591417,0.04104595,0.027297609,-0.08322659,0.0446938,-0.09170499,0.035672467,-0.11457378,-0.025325987,0.025115957,0.14464611,0.004308286,-0.06520874,0.073779754,0.031235734,0.07381278,-0.02046936,-0.053651903,0.018000761,-0.011991973,0.03009593,-0.006521833,0.023891808,0.0011182526,-0.012213697,-0.05593338,-0.026843494,-0.08877331,0.011677392,0.031244215,0.020897377,0.05222657,-0.061315127,-0.024442947,0.09720083,0.028447658,-3.6401662e-33,0.11239921,-0.052690636,0.05052889,-0.08749075,0.0017457544,0.039002206,0.05189376,-0.010817457,0.067258365,-0.08109969,0.05064814,-0.012566748,0.04854939,-0.010842412,0.012017859,0.02943469,-0.011777781,0.032405715,-0.006916732,-0.047773648,-0.0016396126,0.04627269,0.017363183,0.06784697,-0.012066318,0.0133951465,0.00559203,0.09772875,0.0050275424,0.06988422,0.057341285,0.025887907,-0.031013558,-0.030414097,-0.09372747,-0.020125827,-0.1013424,0.05579743,-0.02587609,0.070793875,0.05627815,0.017516725,0.02720743,0.030575735,0.06422576,-0.018309852,-0.048873685,-0.06652783,0.036561646,-0.10419256,0.024472589,-0.036796764,-0.019065825,0.023863798,0.070655175,0.08624221,0.0007197003,0.021990646,0.0113499155,-0.020786041,-0.039723583,-0.05904651,0.08394662,-0.04198225,0.08983806,0.06515876,0.018702101,0.10560044,0.0029668377,0.05292351,0.039802335,0.13793316,-0.05533923,0.06848592,0.0022778942,0.052249175,-0.06837992,-0.028411068,-0.062144537,-0.053462032,-0.021310851,-0.018373964,-0.04839439,-0.00914035,-0.10997997,-0.033231016,-0.008932125,0.05658576,-0.0014382685,0.07065351,-0.0114750285,-0.0077138343,0.0008565093,0.055513714,0.080670364,-4.3313346e-08,0.0027119366,-0.063454516,0.000843242,0.011779132,-0.053910047,0.050134946,-0.03516648,-0.03470303,0.088813215,-0.057186212,-0.07049527,0.07967758,0.026293894,0.07694137,-0.016457232,0.018477615,-0.039192863,-0.05037581,-0.005022194,-0.058758948,-0.074906334,-0.015516707,-0.042244684,0.06506642,0.046559263,-0.024950137,-0.05440334,0.048729405,0.020617994,-0.01660331,-0.016374812,0.082481764,0.041904923,0.0322934,0.012415117,0.031952687,0.024146182,-0.111920826,-0.09319719,0.089345686,0.07878425,0.009945131,-0.076183334,0.008282187,0.03974286,-0.009550369,0.03563482,0.06290981,-0.033440605,0.00474959,0.074145615,0.056701984,-0.059602156,-0.031821776,-0.033005215,-0.016970256,-0.09993064,-0.0581647,-0.01823044,0.022512972,0.07704171,-0.0046191616,0.15413174,-0.01796228 +4.2.1.60,Specific for C10 chain length.,384,1.0,-0.035958864,0.041167766,-0.039729945,-0.06352534,-0.04180643,0.016591998,-0.06668747,0.1779937,-0.027740575,-0.10595195,0.047167636,0.016183028,-0.0026231403,-0.02411924,-0.08421534,0.042248257,0.018345797,0.0172715,-0.021746447,-0.029297983,0.012994957,0.0008790441,-0.0012957762,0.040468607,-0.077102125,-0.10548547,0.015383513,0.051359087,-0.0043170378,-0.053945363,-0.041319743,-0.0027901449,0.04640131,0.02064524,-0.0037034838,0.017913237,0.0058544297,-0.024085786,0.06885787,-0.017712872,0.07708604,0.05946071,0.11359123,0.020788508,0.0069280528,0.012268622,-0.06658341,0.049566675,-0.015203406,0.036646396,0.074024454,-0.004786042,-0.046328846,0.12567782,0.06867903,-0.010198726,-0.1471659,0.008409158,0.050247364,0.0029650426,-0.005271833,-0.023111893,-0.03233365,0.029968968,0.08323549,-0.0048229513,-0.004174837,-0.051144406,-0.04150852,0.051763058,-0.08984553,-0.056407925,-0.012397965,0.06142394,0.038411442,0.038482804,0.020209648,0.0024856944,-0.044868406,-0.07397107,-0.103668444,0.005893926,-0.002340271,-0.027714508,0.04740736,0.058024675,0.07372497,0.058209043,0.024793455,0.037732963,0.035860375,-0.010930827,-0.08115349,-0.07017838,-0.1099289,0.016428536,0.023615705,0.04543242,-0.037371516,-0.005136556,0.08517141,-0.03720592,-0.009797411,0.021889495,-0.06597444,0.078640535,0.01171474,0.073267445,-0.028414585,-0.00044004133,0.0016206811,0.049956173,-0.02782962,-0.10776446,0.013504561,-0.046411615,-0.028389746,-0.02418483,0.08191371,0.021341203,0.06120546,-0.023658419,-0.006529604,-0.048522737,-0.12323743,0.0058469893,0.032214746,-9.882179e-34,-0.0255607,0.031179894,0.048596576,0.04795239,0.047610536,0.01922519,-0.036677245,-0.017237386,-0.010645084,0.051445674,-0.016183179,0.0074008456,-0.05884328,-0.03275719,0.0011564144,-0.028081648,0.04413764,0.047619615,-0.03008014,-0.05722702,-0.04258427,-0.011109828,0.052555103,0.045048323,0.120044895,-0.07672987,-0.035760276,0.0064710258,-0.041664198,0.0074910526,0.036212932,0.039191313,-0.009848663,0.04463398,0.033506874,0.013998636,-0.06344376,-0.018610146,0.04700088,0.008434233,0.037756305,0.026735166,0.020700198,-0.02290406,-0.0711053,-0.052267704,0.013874864,-0.015865419,-0.03360362,0.07735559,-0.015334627,0.033741467,0.043529317,-0.03676602,0.037400402,0.014709549,-0.02758562,-0.03968564,-0.0057514985,0.0467329,0.012156128,0.09884469,-0.031002633,0.023178399,0.002468954,0.051370177,-0.088933796,-0.055983577,-0.022701167,-0.025006376,-0.021174612,-0.08800203,0.060743753,0.09256025,0.040276818,-0.027306108,-0.08004567,-0.036350194,0.024852952,-0.0024835332,-0.08181954,0.012842929,-0.08143071,0.031211322,-0.06102807,-0.07370029,0.055801444,0.015191305,-0.019416427,0.022560783,0.03987423,-0.031668164,0.038193546,0.03094619,0.008966713,3.3364065e-34,0.040419344,-0.01371937,0.09734975,0.010150717,0.013715451,0.009757222,0.1280082,0.053178426,-0.015527002,0.039601766,0.15221904,0.027396668,-0.067356765,0.033188652,0.0521688,0.029802788,-0.06404235,0.007603137,-0.04483556,-0.009743096,0.09980116,-0.028135944,-0.057125278,0.059349474,-0.012804159,0.047860917,0.01109682,-0.018266631,-0.024472484,-0.014553452,-0.097718425,0.004840117,0.0026639686,0.08516217,-0.09205626,-0.066217355,0.039275117,0.099173605,0.037898056,0.0109545225,0.03692385,0.056377668,-0.009810967,0.07298274,-0.08099427,0.017711744,0.08210331,-0.056154862,0.06823686,-0.01900406,-0.037490666,0.04512455,0.06641444,0.0444323,0.027084077,-0.007764063,-0.062778726,-0.012088953,0.05695442,-0.03932715,-0.02505545,0.0133230835,-0.0045660418,-0.0025294276,0.07337281,-0.02813368,-0.06334307,-0.03576156,-0.036238853,-0.024366809,0.021807019,0.01692726,0.061749965,-0.048980445,-0.12215419,-0.10009496,0.040556595,-0.11676997,0.033777416,0.056463398,-0.021697545,-0.04182719,-0.0041343574,0.034941316,-0.002040711,-0.080571555,0.04307842,0.06664527,0.026486743,-0.039199173,0.024590163,0.02320291,-0.009227235,-0.004468991,-0.007509625,-1.30648585e-08,0.008952059,-0.013705817,-0.027545018,-0.07252609,0.009776243,0.07460585,0.019542243,-0.036644973,0.0038174458,0.035536896,0.08087086,0.09497225,0.0350469,0.024228772,-0.044639755,-0.06407391,-0.04384046,-0.058589544,0.0015329521,0.039796136,-0.06830417,0.023968264,-0.034533687,0.015301668,-0.043374855,-0.07576234,0.03403552,0.12106406,-0.018119408,-0.016321346,0.01830477,0.06815721,0.0021167395,-0.029690899,0.017758735,0.0135953855,-0.080678724,0.0402946,-0.016639343,0.055495135,0.053414054,-0.07150822,0.017210454,-0.005371483,0.061611567,-0.03764754,-0.07097087,0.041191347,-0.12090554,0.019770242,0.03907723,0.017999526,0.00702654,-0.038658738,0.006095003,-0.07897562,0.009019822,-0.0072612804,-0.10439552,-0.07094585,0.003173191,-0.008211903,0.06879644,-0.10565319 +4.2.1.61,"The enzyme is specific for 3-hydroxyacyl-[acyl-carrier protein] derivatives (C12 to C16), and has the highest activity on the C16 derivative.",384,1.0,-0.023563178,-0.110254824,-0.07831843,-0.009473262,-0.008698312,0.04505285,-0.065258294,0.07817219,0.029339839,-0.06588441,0.036429428,-0.020373018,-0.07159663,0.052968506,-0.022857739,0.10723777,-0.006066517,0.004132917,-0.04678755,-0.05223188,-0.033871423,-0.027630253,0.055446647,0.076659516,0.027713852,-0.06365908,0.015009369,0.024111828,-0.0032492378,-0.06565958,-0.011921704,0.003208768,0.034786336,0.010014915,0.034535278,0.050138313,-0.07348731,-0.11213352,0.075020984,0.01480083,0.05158661,-0.031182924,-0.006341432,0.012923926,-0.023121502,-0.018984279,-0.063154005,0.07144416,0.091665484,0.036775537,0.022584366,-0.062761255,-0.08928331,0.050031446,-0.024927735,0.017939528,-0.10212281,-0.025678787,0.029769741,0.046706423,-0.036654204,0.029727086,-0.0016783042,0.036785804,0.014562589,-0.065412365,0.0006681185,-0.04711072,0.027275952,0.004901442,-0.08143461,-0.107879594,0.0770657,0.00040918228,0.009606552,-0.021695085,-0.014957097,-0.06319886,0.054774612,-0.10097849,0.009561813,-0.034134325,0.03820815,0.119887345,0.059150692,-0.05882947,0.014098644,0.0063557033,0.030992081,0.059163723,0.031060893,0.0068729273,-0.06188526,-0.02049796,-0.12143701,0.059941724,0.0257674,-0.007928716,0.0015117368,0.020094398,0.023009658,0.048283756,-0.0011155731,-0.06573573,-0.019368438,0.016696762,-0.016994694,0.08461345,-0.009543909,-0.03344063,-0.09096887,-0.022295086,0.0042493967,-0.025520898,-0.03456528,0.104034275,-0.03206489,-0.049370956,0.03261195,-0.028410299,0.04510688,-0.05882538,0.059222825,0.018221844,-0.093849346,0.04116258,-0.038665924,-2.2484037e-33,0.02730821,0.0073572146,-0.009695573,0.0468621,-0.0008363728,-0.004055578,-0.07386112,0.04756617,-0.085316785,-0.0005345233,-0.050566617,-0.031402778,0.033821493,0.025355157,0.035364978,-0.065459356,-0.007465668,-0.0046950374,0.023283793,0.013904808,0.0530897,0.049395204,-0.03090891,0.0024881004,0.017941248,0.0015692483,0.013102757,0.07769963,0.033604864,0.015699554,-0.00059642363,-0.04224076,-0.04040688,0.019128244,0.03559329,0.0576269,-0.050369747,-0.0788185,-0.008103299,0.09919232,0.04189767,-0.034718115,0.007651922,-0.088658616,0.025640415,-0.016827734,-0.04737715,0.077552855,0.011855199,0.050784294,0.04484782,-0.03413635,0.084678054,-0.013767215,-0.009798927,0.0027992078,-0.08232532,0.046195515,0.06041847,-0.007208417,-0.026396755,0.021055037,-0.03825254,0.01921384,-0.02209546,0.028995087,-0.07572763,-0.029095357,-0.0568648,0.105228364,-0.027355975,0.008467409,0.055689294,0.031037988,0.13754293,-0.016673252,-0.05825651,0.06710112,0.035362344,-0.004045924,-0.055338196,0.012274687,0.047996968,0.05612548,-0.077238895,0.010056124,-0.00969999,-0.005642402,-0.024621593,0.033833668,0.06971986,-0.05645987,-0.016400913,0.066940576,0.013172576,2.0017243e-34,0.062958844,-0.11593183,0.010053465,-0.08430778,-0.044076994,0.036027525,0.055250194,-0.049572967,0.027145846,-0.019221017,0.1417957,0.03372187,-0.06382105,-0.08163441,0.030180587,0.0010872527,-0.054582447,-0.024249213,-0.016941445,0.027750269,-0.031830397,-0.022903971,-0.043003965,0.06651427,0.03020444,0.017698176,-0.04205158,-0.006607678,0.077783935,0.09236763,-0.11188116,0.0093872715,0.03171694,0.009465471,-0.0147315,0.08489099,-0.07871256,-0.017167239,-0.01708757,0.05570703,0.011992232,0.0369997,0.01441703,0.051851,0.0865179,0.09790327,-0.061482992,0.030879194,0.032818668,-0.031211652,0.0051447554,-0.04524153,0.036791608,0.033027228,0.009786547,0.08967522,0.0138891395,-0.10003973,0.011388399,-0.07155037,-0.017155718,-0.007910958,0.0015757605,0.029312281,-0.006972847,0.064389296,-0.106791385,0.054570287,0.0005664698,-0.009560257,0.041384727,-0.0072194277,0.0055282097,0.00270256,-0.029292975,-0.1010708,0.0020064318,-0.03592957,-0.025642032,0.009636357,0.031183235,0.037002917,-0.005560925,-0.014288321,-0.07168771,-0.036294416,-0.0017758077,0.040848903,0.054313045,0.013598226,-0.015206352,0.008616155,-0.08812199,-0.0024258168,0.05125789,-3.1163538e-08,-0.0009938837,-0.06828161,0.05113991,-0.08762715,0.04863467,0.082610846,-0.0222405,0.014912243,0.03154869,0.010732368,-0.06275768,0.1273417,0.0033796926,-0.013454009,-0.038855795,0.0024802326,-0.0301475,0.025569512,-0.0012608276,-0.030127509,-0.10060879,0.028473256,0.024423974,-0.024258196,0.028692463,-0.031162985,-0.0005604462,0.040851638,-0.027174396,-0.031110032,0.025785362,0.014170076,0.002260068,-0.014724117,0.0008881539,0.12084741,-0.04527678,-0.049278755,-0.06605624,0.10286514,0.041172836,-0.06679728,-0.02463482,0.012668637,0.071654245,-0.036774233,0.0049113263,-0.0043781647,-0.020495301,0.0034508025,0.008210931,-0.024747793,-0.045978166,-0.06376893,-0.044661622,-0.04425206,-0.069576524,-0.11367739,-0.06844587,-0.11084543,0.0074214637,0.04503912,0.22008345,-0.011582774 +4.2.1.67,Also acts on L-arabinonate.,384,1.0,-0.007659574,-0.043013986,0.0057028052,-0.031210266,0.0031547977,0.1262022,0.04216128,-0.101394966,0.027645243,0.0027424109,0.061931677,0.011310311,0.010298378,0.0032478885,0.014605866,0.03784078,0.015318971,0.0419723,-0.033614714,-0.041540034,0.015510818,-0.02080543,0.04161604,0.03222416,0.026005978,-0.038769633,-0.03907127,-0.03733523,-0.010160825,-0.104734026,0.03414406,0.10083191,0.03493482,-0.036205605,-0.030106492,0.1229305,-0.047406416,-0.0037225634,0.06650597,0.015753029,0.12156088,-0.0980966,0.08394947,-0.033020157,-0.060514256,-0.047467567,-0.04605212,0.017835531,0.0052286927,0.061885692,-0.03834302,-0.05965827,0.014155201,-0.01610534,-0.044243068,-0.042766493,-0.05608835,0.025886891,0.033037037,-0.040398926,-0.029104171,0.06584955,-0.03881095,0.052105088,-0.078814946,0.019070802,0.0824065,-0.045061417,-0.03574815,-0.062047016,0.013383295,-0.029677257,-0.014683462,0.02631098,-0.026036603,-0.009023047,-0.01672591,-0.04781616,-0.081533596,-0.08395683,-0.0012142021,-0.022730276,-0.03707915,-0.021294273,0.013280832,-0.0741513,0.012997348,-0.04436269,0.03200841,0.06457877,0.03516286,-0.027063496,0.047609907,0.023336228,-0.014758075,-0.01510091,0.0033864735,0.028360983,-0.027957747,0.05972305,-0.031600997,0.008523019,-0.034825057,-0.03657255,-0.047687184,-0.062369376,-0.029008774,-0.057561144,-0.043596774,-0.08902829,-0.086924076,-0.034995146,0.03470468,-0.018433891,0.012940388,0.048011575,0.052809935,-0.10894598,-0.02818835,-0.08449286,0.07326789,-0.055040766,0.036888544,0.046280224,-0.029810827,0.05052146,-0.11534404,-2.674388e-33,0.0127993245,-0.084183745,0.00984391,0.0044940882,-0.010816979,-0.0021204166,-0.09234229,0.019887235,-0.061115254,-0.063257,-0.029918648,-0.0013586323,0.048587866,0.034969747,-0.036472466,0.040893096,0.040219944,-0.028936239,0.01893787,-0.010255037,0.0019535618,0.12325996,-0.03313259,0.021140236,0.022730265,0.07235843,0.14515997,-0.04020553,0.030879913,0.07079866,0.022623409,-0.022827737,-0.04610464,0.023922555,0.021644631,0.10160078,-0.14065334,-0.029320305,-0.05445334,-0.015777756,0.044540137,0.060682483,-0.027888842,0.0142081315,0.026022103,0.03599695,-0.0029543722,0.034194577,0.107048206,0.07537074,0.1018178,0.033834457,0.04618405,-0.060401704,0.023694478,0.054031413,-0.050937284,0.095988974,-0.055435978,0.06425159,0.023977412,0.0753641,-0.03259675,0.020682106,-0.0567658,0.052943308,-0.05276866,-0.061164882,-0.00651221,-0.006657663,-0.013665974,-0.052631684,0.11683312,0.08008335,-0.014973257,-0.013591523,0.021075225,-0.10567884,-0.02505102,0.036305387,-0.027454307,-0.034391575,0.0903076,-0.006876342,-0.08534828,-0.012415173,0.061131466,-0.06174736,-0.049950283,-0.03409434,0.004616318,0.027775839,0.0280226,0.022270417,-0.03544719,3.591319e-34,0.019939667,-0.034957778,-0.014082541,0.044801526,-0.013694677,-0.028312236,0.057472635,0.006422723,0.021125825,0.041267484,0.014305883,-0.01861965,-0.0017643292,-0.052522458,0.11699032,-0.06338557,0.081022635,0.024463484,-0.061427444,0.047691047,-0.050714817,0.083353005,0.04795093,0.036718816,0.021825112,0.01642052,0.016897991,0.10612773,-0.05905979,-0.02232833,-0.008447996,0.003606367,-0.13331674,-0.06094767,-0.063240714,0.041454107,-0.052477647,0.005874089,-0.042664897,-0.0318798,0.020224892,-0.023017675,0.0338409,0.05744298,0.0024445807,0.052808683,0.022869745,0.01933391,-0.07716911,-0.08375241,-0.11849669,0.025219899,-0.026174871,-0.003454996,0.082326695,0.0881633,-0.006380868,-0.017935175,-0.04015504,-0.053090334,0.0039589033,0.0029133395,0.03701737,-0.05398261,0.034751896,-0.009347112,-0.0005694493,-0.03520232,0.08023889,0.055066623,0.12999389,-0.019833758,-0.11990921,0.0039653257,-0.06380395,0.016176024,-0.07538275,-0.042984158,-0.060226794,-0.06936752,0.023221347,-0.05918351,-0.06431948,0.014009349,0.06527948,0.01001787,-0.022287924,0.034791827,0.03411548,0.106147915,-0.04075804,-0.07448402,-0.03359507,0.04401135,-0.0065482277,-1.7868201e-08,-0.017851738,0.000498567,0.056544468,0.0455096,0.022798132,0.037271954,-0.016147837,0.05381212,0.0045928885,0.08114063,0.005258454,0.017227931,0.031076608,0.029503895,0.045030687,-0.049504172,0.044191178,0.03657587,-0.0973721,0.05429264,-0.09242937,-0.050968256,-0.014699466,-0.027930275,-0.0603918,-0.014074273,-0.0062056114,0.027841853,0.0698976,0.021710007,0.035421934,-0.024633015,-0.017551627,-0.061383944,-0.04238888,0.03697506,-0.036106672,-0.020063348,0.017392658,0.03741934,0.0014409935,0.053578056,0.027632771,0.090144664,-0.011806731,-0.0073682275,-0.024142109,-0.042805135,0.019454904,0.037512287,0.10548441,-0.012717324,-0.06868653,0.062174484,0.027361397,0.009111809,-0.009100089,-0.018717527,0.070640326,0.013901554,0.042232584,-0.04791196,0.08271924,-0.034082647 +4.2.1.68,"Also acts, slowly, on D-arabinonate.",384,1.0,0.024613598,-0.04104185,0.053862806,-0.016529046,-0.029382642,0.04444643,0.035739776,-0.10288551,0.04515556,0.045708086,0.050343156,0.013636635,-0.025912661,0.02649653,0.038070362,-0.020344974,0.034775227,0.070409596,-0.043397658,-0.011638946,-0.015474682,0.0014905622,0.058706734,-0.008290969,0.007193773,-0.0046259565,-0.016763734,-0.015158319,0.012427646,-0.10932193,0.008464179,0.07090816,0.038337152,-0.010863988,-0.04202811,0.16220647,-0.0064196317,0.042700555,0.059174802,-0.01187412,0.12445196,-0.049495313,0.09105548,0.010673905,-0.043328635,-0.016878625,-0.06578139,0.03991615,0.01195612,0.00594557,-0.06749456,-0.07370746,-0.0057695378,-0.03003491,0.00882806,-0.033096,-0.015371853,0.037774418,0.043306377,-0.10027945,-0.013026116,0.020830262,0.022621922,0.042847227,-0.024652552,0.007496139,0.09640203,-0.025960352,-0.028717887,-0.014800846,0.0147734955,-0.0014431879,-0.03701072,0.0068839127,-0.07822987,-0.08307298,-0.022420323,-0.10098224,-0.04864309,-0.1108306,0.013955207,0.005691929,-0.0155289825,-0.0049415473,-0.023902563,-0.02395784,0.033544462,-0.07807471,-0.032683413,0.04465654,0.019027261,-0.023465285,-0.016009802,-0.02785769,-0.015720822,-0.0057245223,0.011232073,0.04785569,-0.033792827,0.040814783,-0.009672696,0.035186544,-0.061158873,-0.008880216,-0.050334092,-0.06963724,-0.0214617,-0.061054915,-0.090620905,0.0053339573,-0.106326625,-0.052854642,0.0097436905,0.0179502,0.0022985472,0.030938623,-0.015202871,-0.08131663,-0.04046457,-0.0283219,0.049319632,-0.0064993077,0.063716985,0.046096254,0.005375338,0.051297247,-0.05264692,-2.8936728e-33,0.037230145,-0.13459529,-0.021513246,0.009902695,-0.06868474,-0.033695124,-0.08101728,0.03526392,-0.021281365,-0.06618735,-0.06712548,-0.05274206,0.03647679,0.0893652,0.010978169,-0.002165794,0.043912664,-0.039324783,0.003969431,-0.03945862,0.0074813776,0.10722583,-0.029684408,-0.0025618933,0.06329446,-0.01119331,0.08780969,0.026298495,0.038774464,0.035443723,-0.01632196,-0.04327438,-0.059545286,0.052464053,0.03209081,0.09761957,-0.11127635,0.0024377508,-0.043370984,-0.02502313,-0.014142435,0.018075258,-0.06919201,-0.03175578,0.012453675,0.054515906,0.010008617,0.046948712,0.011049922,0.09779846,0.11792675,0.060553685,0.08436528,-0.061050255,0.00174663,0.0578543,0.022530397,0.03785915,-0.076197885,0.11406732,-0.010029952,0.04114791,-0.027537199,0.014540039,-0.047723413,0.04508075,-0.07659811,-0.031617466,0.0019994413,-0.008332636,0.0013230154,-0.031970493,0.0703668,0.023893429,0.0005838276,-0.028401803,0.04233321,-0.13229994,-0.037992153,-0.0019377344,-0.02826103,-0.019811956,5.0306146e-05,-0.0027089915,-0.06825746,0.02252681,0.06480212,-0.10363077,-0.0501651,-0.0128743565,-0.022670886,0.012296494,-0.0099497335,0.0017145245,-0.011537491,1.7700867e-34,0.0028044241,-0.0072651235,-0.010692285,0.08668807,-0.009279978,0.027139653,0.020839775,0.074159704,0.039273623,-0.0066864775,-0.01419728,-0.023435757,-0.040496804,-0.031623535,0.08223543,-0.021435283,0.05989417,0.041922912,-0.0044277697,0.040153444,-0.008304733,0.08906811,0.0010318226,0.03962667,-0.0061961496,0.022451676,-0.0034177739,0.09416731,-0.07948347,0.010430314,0.025670443,0.057859372,-0.1234842,-0.0035657014,-0.063543595,0.09352353,-0.095649056,0.0012638464,-0.09486611,-0.03323825,-0.027116798,-0.00019274348,0.06835803,0.07900839,-0.003736173,0.06924518,0.027287366,0.05679067,-0.103231296,-0.014832607,-0.06759159,0.038691364,-0.005890261,0.008980745,0.09019608,0.073437385,0.009614118,-0.03314305,-0.067624785,-0.021542113,-0.007860645,-0.021716053,0.08050219,-0.046194434,0.046729315,-0.04111052,-0.018220982,-0.018608905,0.07781288,0.047382906,0.09786396,-0.024616072,-0.15441208,0.022656243,-0.07101463,-0.014455499,-0.079082735,-0.024772018,-0.006677042,-0.032397613,-0.024223937,-0.00523004,-0.05376587,0.02660642,-0.061070915,0.04874984,-0.042434126,-0.037887163,0.022762828,0.13768327,-0.041484945,-0.0662913,0.027131725,0.060819928,-0.059986096,-1.9766858e-08,-0.004753802,0.0020733862,0.10132343,0.03772249,0.032633405,0.056546114,0.04035431,0.12493659,-0.0056465324,0.058055848,0.006326929,0.04899602,0.040800307,0.049070176,0.06207298,0.008076602,0.014600374,-0.016343392,-0.10457214,0.020323558,-0.07311945,-0.046615604,-0.06594717,-0.045666296,-0.0966812,-0.016915001,0.010221531,0.035025172,0.028715722,0.039828416,0.03893394,-0.04156575,-0.036769874,-0.07723532,-0.05477112,0.018365668,-0.006448551,-0.020300062,0.02961848,0.042949583,0.017949091,0.027910523,0.03541978,0.07494843,-0.037955225,-0.035335436,-0.042127,-0.06725712,0.018181259,0.016604418,0.10996997,0.024161544,-0.07257111,0.035799738,-0.013873508,0.054961782,-0.019235913,-0.027736817,0.028221702,0.048241526,0.06602584,-0.0330958,0.077798516,-0.014808972 +4.2.1.70,The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo [5].,384,0.99999994,-0.09920801,-0.047723368,-0.110529885,-0.018186584,0.024131708,0.0076796836,-0.08656741,0.018053817,-0.023375912,0.04635462,0.020448202,0.046134945,-0.08831161,0.009587247,-0.06874175,-0.07322723,-0.059705354,0.02459339,-0.010040241,-0.09532287,0.09001845,0.042193707,-0.060698688,-0.046525434,0.036028016,-0.008538788,0.016813053,-0.033496555,-0.038058534,-0.018827885,-0.08133489,-0.07716585,0.011448253,-0.11039506,0.06662109,0.09335645,-0.06276,0.008284175,0.08676477,0.00088952156,0.051994942,-0.033637203,-0.06607648,-0.06796169,-0.021126116,-0.03379144,0.0053627538,0.023661854,0.031063119,0.0513957,-0.059940975,-0.010794042,-0.05631402,-0.0421881,0.000861289,0.030714348,0.0027385538,-0.0148232505,-0.014987588,0.03112743,0.02561592,-0.059475675,-0.024545707,0.02369129,0.008478595,-0.051612172,0.084318,-0.06939153,0.01616186,0.02539719,-0.01525698,0.00408465,-0.00034638538,0.03818923,0.0509663,-0.022526227,-0.082187384,-0.02909028,-0.010376932,0.08080008,-0.0020002217,-0.086417414,0.025072008,0.049156927,-0.020335054,-0.033166684,-0.031936985,0.03558459,0.067790106,0.013791432,0.01996804,-0.0069697318,-0.0058910716,-0.06620462,-0.019064395,-0.012026018,-0.036251225,-0.04210505,-0.0036099015,-0.09104913,-0.036720004,0.011738055,-0.02718662,-0.069487445,-0.032460384,0.04464472,-0.029275093,0.05090804,0.012624801,0.047479536,-0.0074492563,0.073445305,0.06065846,-0.029747974,-0.044984743,0.015723934,-0.0059565473,-0.09488926,-0.058825895,-0.045771174,0.039264873,-0.031849746,0.061562393,0.12022015,-0.0031265111,0.011851117,-0.0008707603,4.6168823e-33,0.02784076,0.09602223,0.072754055,-0.04599837,0.024140831,0.016922086,-0.028533679,-0.017581815,0.0038730404,-0.028582912,0.01879602,-0.009544348,0.034213085,0.011894899,-0.056856453,0.04728896,0.024454439,0.01568301,0.052790657,-0.020750314,0.057794034,0.127973,0.009739068,-0.018368691,0.047769025,0.07898406,-0.03379003,0.028748905,0.056745496,0.0013323755,0.049088538,-0.086478315,-0.13333033,-0.00045583618,0.11760847,-0.024659151,-0.022147572,-0.029140612,0.018399322,0.10750798,0.040865995,0.0123951845,0.021148654,0.050580245,0.026060974,-0.018702243,0.0062353024,0.04932132,-0.0066115432,0.046973515,0.018632283,-0.01680558,0.038523357,-0.011080411,-0.06822092,0.005246019,0.05260001,0.007712329,0.00770692,0.077483684,0.045823533,0.06371496,-0.0021616227,-0.016172761,-0.05043516,0.009447993,-0.041936472,-0.057553645,0.037573505,0.072292864,-0.055221684,0.043745782,-0.0008996538,0.051870365,0.01748666,-0.035134733,0.009667827,0.059605215,-0.0437016,-0.03291596,-0.015129222,0.0006363281,0.006430127,0.025275677,-0.0491434,-0.040864818,-0.048510265,-0.0568775,0.025715485,0.03618007,0.08631599,-0.093264535,-0.05346853,0.053409856,-0.06965681,-4.9426073e-33,0.090316206,-0.09102284,0.048573703,0.009027322,-0.11519197,-0.02652348,-0.003963247,0.065731235,0.025819145,-0.054211468,0.013257877,0.031716224,0.06680971,-0.01317717,-0.046403702,0.061706845,0.09711456,0.06440578,-0.039653562,-0.052047633,0.015149147,0.06351243,0.05436756,0.018782452,0.072726876,0.034132075,-0.02350267,0.037770633,0.02647853,0.018352145,0.038341064,-0.0014557885,-0.039115135,-0.07023888,-0.04470888,0.042745423,-0.098007075,0.026166871,0.07694081,0.02242888,0.074159294,0.08437194,0.025555354,0.027945872,-0.027698291,0.038957834,-0.07304876,-0.006815904,-0.066610076,-0.06707613,0.048459496,0.034052312,-0.012998917,-0.02756172,0.08871429,0.0064434246,0.029900188,-0.012144982,-0.038974654,0.018929185,0.026016604,-0.072884336,0.054569863,-0.02953691,0.05936469,0.10604627,-0.029301051,0.098446265,0.010460011,0.03118687,0.035222705,0.029987196,-0.016115932,0.0064231497,-0.012503431,0.0073014232,-0.07743068,0.039243873,0.054990068,0.036109753,-0.03202557,0.0013791563,0.0016965065,-0.07648663,-0.0024175334,-0.036303777,0.03651424,0.13057484,0.023301765,0.020139148,-0.012265198,-0.09241178,0.060238406,0.06897533,0.068455316,-3.5701895e-08,0.045453303,-0.089610964,0.049935978,-0.030808298,-0.05105518,-0.011707076,-0.030149996,-0.011522071,0.013639867,-0.07802004,-0.07527494,0.032466464,0.023090616,-0.04564658,-0.00759564,0.11761806,-0.104405545,-0.037410837,0.005606299,-0.039282344,-0.047782466,0.01359897,-0.21482234,0.048728667,0.047732893,0.04680146,0.04285021,-0.048188493,-0.004384265,-0.022792358,-0.024487268,-0.0539814,-0.026570838,0.04536814,-0.049400292,-0.034307744,-0.0061520254,0.00402468,-0.0034056653,-0.05861839,-0.028723458,0.019589122,-0.0725694,0.03925497,-0.07692175,0.012641583,0.03022676,0.01571107,-0.020448761,-0.046170402,0.044859435,-0.009338447,-0.01901295,-0.023039317,-0.06475898,-0.055918593,0.02478418,-0.043907188,-0.08259461,-0.008001207,0.023408886,0.04990727,0.17601411,0.020513054 +4.2.1.73,"The product is converted non-enzymically to erythroaphin, an aphid pigment.",384,1.0,-0.051246043,-0.01650445,-0.091594875,0.022428151,0.05775768,0.061290525,0.09513551,0.04327202,-0.039754763,-0.0105889,0.10728178,-0.09512878,-0.08503702,-0.040417895,-0.05444079,0.12314762,0.0066896887,-0.0010330891,-0.023276968,-0.05808369,0.09383839,-0.0026012827,0.040664256,0.0037178942,0.026688024,-0.04094425,0.0025255743,-0.025316408,0.030229973,-0.10965997,-0.016767453,-0.041174527,0.07508538,-0.02215901,0.032436416,0.0367978,-0.052383382,-0.05661932,0.056395207,0.0032378347,0.08073617,-0.008436744,-0.083990924,-0.020201448,-0.025269747,-0.031387303,0.030175352,0.026298687,-0.027307559,-0.04089204,0.033243503,-0.039118,-0.08064996,-0.058609482,-0.042474132,0.022782307,0.015231278,0.0066035357,0.007720189,0.04768308,0.06418262,0.009546818,-0.0070498097,-0.013730703,0.0065488834,-0.007926882,0.07058954,-0.11547751,0.021165455,-0.09134119,-0.0064288205,-0.05099116,-0.024886213,0.055841062,0.015530799,0.021334805,-0.0016644183,-0.0001522041,-0.0007709086,0.028369738,0.021576207,0.03731636,-0.020468427,0.10947916,0.07817982,0.031396303,-0.08027298,0.081503116,-0.06532911,-0.009530154,0.012186572,-0.022149745,-0.030191809,0.0061289775,-0.034332965,0.050309915,0.03826741,-0.029298732,-0.0016435353,0.017873041,-0.09181009,-0.021506706,-0.024255918,-0.14155108,-0.087027766,-0.03953796,0.027285678,-0.024898829,0.016413001,-0.053750005,-0.044777445,-0.021957135,0.026093923,0.017760525,-0.04237153,0.01972997,-0.019395122,-0.014972092,0.02721409,0.09548416,0.04895771,0.06295138,0.06757978,0.11286112,-0.024604369,-0.06002468,-0.0035011196,1.7903863e-34,0.043543685,0.007824206,-0.01876269,-0.027751934,0.009401281,0.0751065,-0.00076068466,-0.07660999,0.043763455,-0.05147842,-0.030895583,-0.08525461,0.026988525,0.069510154,-0.03841237,0.026702493,0.058931362,-0.01698024,0.10458293,0.023971878,-0.016689984,0.11500671,-0.08355749,-0.017201653,-0.040520202,0.011045261,-0.07418423,0.0010041207,0.061513804,-0.018605886,0.061971176,-0.048896704,-0.03269297,0.06632645,0.022582527,-0.016630437,0.013947752,-0.063292645,-0.028046804,0.007387255,-0.059361316,0.03190732,-0.0057330383,0.03192731,0.08567041,-0.010296666,-0.040708,0.018183352,-0.0013679019,-0.010053317,0.00407387,0.042037044,0.122722656,-0.014356729,-0.027348215,-0.014269547,0.05607485,0.0013387505,0.031201063,0.013430463,0.03730016,0.078463376,-0.02938382,-0.03874794,0.0066657476,-0.0033133533,-0.032386523,-0.025252048,-0.025687067,-0.05719129,0.050331034,-0.059559423,0.022486404,0.026391305,-0.015270803,-0.039246168,-0.024998164,0.06424642,-0.02834457,-0.015796296,-0.05105433,0.05349173,-0.020815985,-0.060487818,-0.04241341,0.048890993,-0.01808243,0.024358593,0.037439883,0.008407636,0.08173357,-0.053304195,-0.05840593,-0.039671298,0.0029727104,-3.982664e-34,0.02637562,-0.02318968,-0.08434939,-0.017013665,-0.025151161,0.07237429,0.031634454,0.08358811,0.040158547,0.07458695,0.047528837,-0.0013075217,-0.011516156,-0.054514892,0.012420109,0.08904867,0.0352564,0.17762507,-0.015122795,-0.020151827,-0.104764976,0.09526032,0.016117506,0.012925882,-0.0015841583,0.031233473,0.019458141,0.072170585,0.023006408,-0.019763537,-0.05563133,-0.10845979,-0.063646905,-0.080961354,-0.043447733,-0.00881526,0.011180176,-0.08252024,-0.08721619,8.734255e-05,0.04382703,-0.022083968,0.0027038602,0.009157292,0.057253733,0.11595355,-0.08256311,0.03566898,-0.007818516,0.0022836674,0.07088814,0.034668364,-0.01164066,-0.025405433,-0.005356245,-0.022053985,0.050021335,-0.00012625288,0.013214527,0.0414617,-0.0081901,-0.09674547,-0.0037481613,0.018081376,-0.0022363118,0.1161141,0.005768998,0.080738656,0.044708718,-0.04546171,0.07970926,0.030846348,0.023598377,0.012375087,-0.025954975,-0.007031574,0.015358698,-0.044375084,0.031493206,-0.11363366,-6.756874e-05,-0.059383735,-0.02978379,-0.010643386,0.041319747,-0.065523595,0.000920889,0.0020667342,0.008397391,-0.032283872,0.018211922,-0.0007141569,-0.0349415,0.08869393,0.11787081,-2.2474731e-08,0.09195415,-0.04834702,0.06831248,-0.046154775,0.016299762,-0.026434653,0.021157296,-0.032011904,0.026136186,0.017367339,-0.05257668,0.0016080829,0.014846493,0.05777594,0.08336495,-0.009985143,0.09266368,0.0749328,-0.0031309521,-0.04981322,-0.105028585,0.03520582,-0.05843417,-0.0059155985,-0.026887383,-0.05942247,0.036109257,0.0051471884,0.03553471,-0.00020651681,0.05541012,0.02741414,-0.023917306,0.0037714161,-0.07050001,0.042151965,-0.045206193,-0.033530265,-0.02476526,0.021054475,-0.11175861,0.021901703,0.014893742,-0.015312468,-0.0042556026,-0.025705762,0.025157202,-0.046365283,-0.02310555,0.011126734,0.054913875,-0.06306619,0.028681753,-0.07900967,-0.15137552,-0.08832745,0.07915098,-0.032256167,0.0024453148,0.01919695,-0.008776032,-0.015457637,0.14754519,0.029818404 +4.2.1.74,"Acts in the reverse direction. The best substrate for the porcine enzyme is oct-2-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA.",384,0.99999994,-0.02424173,-0.12678319,-0.0071696867,-0.11270849,0.026569117,0.017979199,-0.0720468,-0.0034183688,0.03727758,0.010262672,0.042770382,-0.057946995,-0.034027345,0.15755382,-0.017722426,0.0028921044,0.010040335,-0.040172093,0.08421512,-0.0023489457,0.03168338,-0.052325293,-0.035112098,0.015436471,0.007825229,-0.0090073375,0.06567087,0.03146462,-0.00075451,-0.0740842,-0.06174145,-0.0055480264,-0.043193854,-0.06835923,-0.018707404,0.10583811,-0.03172625,-0.049221832,0.04533918,0.054916687,0.054031365,-0.04642658,-0.023513844,-0.039944366,-0.0122512635,-0.06559092,0.030993884,0.014209705,0.033933625,0.02976409,-0.034893613,-0.05185501,-0.09202605,0.047351696,-0.059929542,0.04868126,-0.09426142,0.06291033,-0.03766805,-0.010043827,0.030262621,-0.018833373,-0.015380144,-0.009670497,0.051166654,-0.02708051,0.02662014,-0.01295227,-0.018329108,-0.010361312,-0.014731197,-0.10461861,0.027198367,-0.010662987,-0.014484028,-0.0019869069,-0.0113825975,-0.011343528,0.016195133,-0.01022917,-0.028899688,-0.008347515,-0.027122086,0.080458984,0.09032987,0.045457944,-0.033009447,-0.02105418,0.068418115,0.030202247,0.027488364,0.0041012065,-0.0014955904,-0.059075247,-0.018095134,0.02640057,-0.022997603,0.04491939,-0.0060267327,-0.015464929,0.0025574113,0.08120884,-0.079616904,-0.0075404686,0.035120185,-0.0221827,0.012969098,0.12996612,-0.017181698,-0.019719698,-0.052439835,0.02117058,0.09209239,0.053387538,0.011850304,0.11716269,-0.057910148,0.002681767,-0.023643283,0.029843135,-0.02671569,-0.00028416063,0.034357443,0.06419855,0.016177936,0.07740448,-0.059555493,6.082422e-34,0.06452988,-0.0018732771,0.07370437,-0.033839926,-0.058385182,0.021296859,-0.076539315,0.08151659,-0.065721735,-0.056278333,-0.047894176,-0.003533967,0.04217514,0.021064147,0.010931293,-0.0909293,-0.03394308,0.02795366,-0.019962927,0.036815137,0.044260435,0.03583709,-0.05753457,0.015647395,0.001830582,-0.0090100635,-0.041170076,0.026007673,-0.0147190755,0.03767516,-0.033131056,-0.074169606,-0.019756414,0.007702113,0.032516073,-0.02755363,-0.07500387,-0.012221698,0.021175874,0.05062834,0.067279555,0.04123079,0.006050238,-0.019616516,0.04388301,-0.014558432,-0.0330377,0.07571417,0.006710656,-0.05097119,0.11525132,-0.039271835,0.06190157,-0.020245977,-0.036059897,0.016391749,-0.034251086,-0.010241387,0.0018248459,0.06407758,0.014669112,0.030861286,-0.015291346,-0.006685235,-0.0066491636,0.02165174,-0.0920895,-0.086773545,-0.02569573,0.052978747,-0.03517058,0.03321573,0.048238162,0.033981092,0.03611584,-0.07284073,0.0062507107,-0.008622747,0.06409592,-0.039022986,-0.00023545351,0.028041985,-0.0068245414,-0.00972875,-0.04243429,-0.046691526,0.08270346,-0.09825024,0.024758553,0.055932187,0.064075984,-0.062452078,0.0009066745,-0.01026341,0.0054094396,2.409807e-34,0.054570656,-0.10968257,0.06301542,-0.07801238,-0.12229845,0.07738615,0.07143847,-0.06617283,0.11648068,0.021056553,0.09210662,0.040829122,-0.059734672,-0.013592778,0.018433996,0.08530405,0.0040650168,-0.07098483,0.013938263,-0.09599456,-0.071417004,0.03852453,0.05552008,0.043802757,0.082331255,0.039531108,0.008427077,0.07107788,0.07628665,0.013189612,-0.08622253,-0.0048346836,7.141779e-05,0.0685804,-0.07098544,0.09112838,-0.05106808,-0.0053493367,-0.01050833,-0.02316021,0.012586541,0.013819157,-0.019161502,0.10078635,-0.049703166,0.037165992,-0.036681015,0.021153739,-0.059207264,-0.037935108,0.009394515,-0.024428662,-0.0076450026,0.030352619,0.0149841895,0.07098772,0.0088095395,0.0007766664,-0.028821,-0.0041667996,0.0025441174,0.060590487,-0.01064386,-0.0163395,0.039410226,-0.0024975897,-0.03015935,0.069585375,0.014654829,0.0030866482,0.046427883,-0.0011012634,0.03897733,0.020580338,0.030793594,-0.013913771,-0.06789678,-0.022570116,-0.03477756,-0.06658339,-0.08193731,0.037006762,-0.038700484,-0.002629601,-0.06267761,-0.05025,0.010179854,0.12650503,0.035764147,0.08034953,-0.019723581,-0.060839355,0.03160125,0.0967011,0.16742544,-3.183729e-08,0.006583425,-0.09896214,0.07304636,0.010188229,-0.018442186,0.08422772,-0.023795996,-0.039328165,0.06463133,-0.049074322,-0.08079461,0.04637715,0.05639585,0.020190926,-0.010512615,0.06898901,0.0031580585,-0.005995034,-0.042856965,-0.036582723,-0.092939295,0.009551257,-0.09644396,0.020232746,-0.027087605,-0.022642888,-0.02529445,0.11250156,-0.07921811,-0.006089714,-0.0006577875,-0.020108933,-0.0062084273,-0.026642762,-0.061152995,0.048122488,-0.0072313426,-0.0027766295,-0.053856052,0.0838092,0.038104482,-0.043023396,-0.0601806,-0.0048762397,0.041923758,0.038467336,0.02939379,-0.0095325615,0.017214837,0.011240255,-0.005748873,0.005105116,0.01944039,-0.06465913,-0.070459746,0.017245423,-0.09953549,-0.122598894,-0.014561952,-0.010435701,0.0064489106,0.100122906,0.15218005,-0.04769748 +4.2.1.75,"In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen III from porphobilinogen.",384,1.0,-0.024775693,-0.015319321,-0.08203039,-0.021080606,0.02505662,-0.020286333,-0.037877873,-0.006257929,0.003457862,-0.023689695,-0.006138936,-0.066400714,-0.08869313,-0.015635464,0.0034774875,0.05641675,-0.08579762,0.029360637,0.016904294,-0.0032907568,0.09498184,-0.02367293,0.014440702,-0.066649765,0.040428013,-0.077090696,0.025887646,0.02259096,-0.0059082448,-0.066066355,0.048503794,-0.023262596,-0.037884936,-0.0901662,0.124752,0.036729872,-0.040804718,-0.107591935,0.06334408,0.06529061,0.046158887,-0.044359833,-0.074163005,0.0077352985,-0.0351018,0.04465582,-0.009854486,0.044362515,-0.02203503,-0.04485687,-0.041582834,-0.07318733,-0.022240452,-0.0067825173,-0.004952489,-0.063471705,-0.030801548,0.0051569594,-0.009173404,-0.018091256,0.055471763,0.052676197,0.058078367,-0.07243591,-0.004000375,-0.014110105,0.03437683,-0.053340457,0.12170096,-0.082242794,-0.10936234,-0.04805839,-0.0025498373,0.03981384,-0.049997576,0.0147716375,-0.0113837095,0.013216977,0.049510542,-0.042890444,0.0803133,-0.0035967594,-0.043717366,0.03063925,0.0833846,-0.042296045,-0.0064036935,0.0311075,-0.000610046,0.063506134,-0.030408306,-0.021513743,0.071412876,0.041512556,0.0062061814,0.062067546,0.026735974,0.03517686,-0.0025354598,-0.025170196,-0.028155554,0.016065883,-0.0009791635,-0.046738748,0.048054345,-0.024929803,0.05077845,0.1159785,0.05001912,0.03922976,0.0031412872,-0.0374003,0.05374925,0.020336092,-0.030916011,0.086416475,-0.011928537,-0.015428159,0.00710512,-0.009573511,0.019561233,-0.020557828,-0.042777516,-0.0011463735,-0.10912029,0.051503863,-0.057275325,2.1041277e-33,0.09933218,0.09111093,-0.0039067217,0.019870203,-0.03249321,0.025550215,-0.0100369295,-0.04695128,-0.025746146,-0.10229341,-0.13023604,-0.09016532,-0.017381903,0.014771907,-0.06938831,-0.05824116,-0.092569396,0.10594321,0.03329004,0.0023385766,0.06304882,0.011085339,-0.08501203,-0.035304084,-0.003796151,0.059205443,-0.022730486,-0.0726779,0.08490191,0.010279145,0.036806494,-0.056657463,-0.05815476,0.033874277,0.06270671,-0.10362201,-0.002093367,-0.036377594,-0.06471934,0.03968889,-0.060201235,0.017331649,0.033885352,-0.06193475,0.10054839,-0.013198658,-0.08402744,0.056403458,0.06321965,0.039407436,-0.077765204,-0.02672706,0.054201398,0.06680218,-0.027878277,-0.079084694,-0.019861994,-0.0630001,0.016700843,-0.031535763,-0.037297197,0.18915603,0.062586434,0.011551808,-0.0029959558,-0.011072809,0.008312369,-0.011914819,-0.004258155,0.06560891,-0.01314738,-0.0460959,0.00887116,0.031422235,0.0710348,-0.06177905,-0.02645491,-0.010717911,-0.0042675175,0.0007311766,0.018586652,-0.0075133415,0.03141478,-0.02619125,-0.02949199,0.011284259,-0.029314218,0.021634085,0.020174364,0.04531943,0.0941129,-0.01172149,-0.04824725,-0.007919315,-0.06427903,-1.6639806e-33,0.13474251,-0.037709836,0.055762704,-0.09414189,-0.07327901,0.06285346,-0.06885638,-0.030395828,-0.004496007,0.0705371,0.08300186,0.003539632,0.052631553,-0.107705794,0.015049874,-0.053059246,0.025797667,0.021190437,-0.0045184856,0.022824053,0.016341014,-0.047053024,-0.0658845,0.07690117,-0.021283014,0.0093396865,0.06594002,-0.046694204,0.06750063,-0.0070532556,-0.01907621,0.017139615,-0.023979455,0.0090115825,2.0443586e-05,0.01664067,-0.05248921,0.014445266,-0.03629356,-0.008146654,0.011951274,-0.030789703,0.021279927,0.055780556,0.060897715,0.019136058,-0.031687092,-0.03984097,0.0030010166,-0.012060299,0.047362812,-0.0011643773,0.027216773,-0.0153935645,-0.0064253286,0.02545675,-0.03063668,0.06369357,-0.10433026,0.004224259,0.027982002,-0.013060903,0.053321797,0.0117461635,0.0318838,0.084455945,-0.030736024,0.10936398,0.025278794,0.032812174,0.047758315,-0.017884428,0.0034731065,-0.006613096,0.029492307,-0.019824665,-0.04056691,-0.008419262,0.03916172,-0.087242134,0.027978726,0.03881148,0.049857654,-0.07068077,-0.0012423355,-0.02542119,0.014323961,0.111467965,0.007977756,0.06990215,-0.0031153897,0.016000092,-0.13993916,0.04501512,0.10000639,-3.0077434e-08,0.028433824,0.030823084,-0.010424902,0.005794907,-0.012133219,0.042931743,0.008579022,0.03593384,0.06605484,0.030643031,0.012339317,0.017919298,0.093616925,-0.021526692,0.09434877,-0.027321404,0.005393713,0.076640554,-0.006728094,0.032272764,-0.037719384,0.00052651746,-0.112519436,-0.0057182782,0.035710976,-0.012848483,0.049325783,0.048867453,-0.011653728,0.019297173,0.054455824,0.03515402,-0.060118057,0.005389079,-0.06570407,0.048016004,-0.034489185,-0.059279118,-0.0331202,-0.027657608,-0.041653346,-0.009899047,-0.03594866,0.027158208,0.053938914,0.030969366,-0.028833155,-0.013520841,-0.038033236,0.010421208,0.042765666,-0.0092081865,0.023789888,-0.08938621,-0.114510715,0.0957906,-0.059625316,-0.044507362,-0.08752303,-0.05349138,0.0503801,0.0077882023,0.13921617,0.046394043 +4.2.1.77,Highly specific.,384,0.99999994,0.019630184,0.020524966,-0.0230152,-0.020047296,0.024092974,0.0406417,0.01810513,0.021626374,-0.087683104,0.025034381,0.049981266,0.07347534,-0.03327476,-0.005415522,0.014728936,-0.03250771,0.14855814,-0.08265671,-0.08764366,0.0051208395,-0.008628811,-0.0033209734,0.062129613,0.01479178,0.017975545,-0.021437574,0.018815499,0.06956224,-0.014540581,-0.033472992,0.00985978,0.035012644,0.04077409,0.016629338,-0.074339546,0.12060398,-0.06889379,-0.0019449351,0.07577824,0.0128357,0.026173191,-0.012304484,0.034301944,-0.008898489,-0.0014370269,-0.022970771,-0.039906796,-0.016499123,-0.04642852,0.008880071,-0.009253621,-0.06546112,0.04591092,0.016099604,0.032182988,-0.065169394,0.03340078,0.011741369,0.071402214,0.032650072,-0.004116478,0.035665374,-0.08813003,0.021229845,0.1509717,0.0002472862,0.006332941,-0.046821017,-0.03000914,-0.02007239,-0.05246243,-0.040659763,0.027719542,0.009111694,0.07351445,-0.05729846,0.04702543,0.0064067594,-0.015810262,-0.056710877,-0.039893474,0.04909444,-0.0063509145,-0.009688946,0.08913302,0.053284056,-0.024151355,-0.029503722,-0.016472684,0.016280608,0.012094162,-0.07541018,0.11545992,-0.04950364,-0.030986318,0.0024644723,0.042414233,-0.10705784,-0.016860437,0.08021278,0.00860762,0.004037125,-0.03389221,0.050065465,-0.008436746,-0.060979486,-0.047801893,0.054549146,-0.06995602,-0.090007484,-0.11495861,0.0024508026,0.024528276,-0.033106238,-0.042515025,0.05307322,0.023206132,0.023664039,-0.012510923,0.039957467,0.026200978,-0.00594072,0.014255891,0.0049632443,-0.08309666,-0.032914195,-0.073286496,-7.926854e-33,0.03455006,-0.031404287,0.014410953,0.16132574,0.006539816,-0.0012397327,-0.0030263695,-0.012293285,0.013739783,0.067143,0.040282838,0.028888106,-0.07640751,-0.00097101065,0.07610626,-7.87875e-05,-0.08878439,0.058396786,-0.019405626,0.0017028035,0.019590734,0.030960713,-0.037802022,-0.04255902,0.029849818,-0.03250836,0.022277417,0.013941744,0.08840643,0.01628505,-0.061007418,-0.003636679,0.009472894,-0.06365878,0.073859066,0.029568287,-0.010664959,-0.051574916,0.020352978,0.023539122,-0.03575704,0.02146051,0.0051506995,0.09166367,0.04022605,0.033915803,-0.020297216,-0.010514895,-0.10557859,0.017497253,-0.10106621,0.021576107,-0.047632392,-0.03696988,-0.010676392,0.026443284,0.019515676,-0.0055166516,0.0785784,0.013454503,0.013761928,0.12697288,-0.09642051,-0.010007327,-0.07321037,0.058839895,-0.03780467,0.040001158,-0.006584064,-0.011659435,-0.05025824,0.035931997,0.19829985,-0.063189216,0.0035671045,-0.011519132,0.030885028,0.09217766,-0.029138278,0.0038970336,-0.06267852,0.06740324,-0.012650777,-0.004273909,-0.010017325,0.010221874,0.06546703,-0.108032525,0.0076424284,-0.03148979,-0.0564091,0.0041891793,-0.04870975,-0.112549126,-0.05134836,6.412181e-33,-0.04432546,0.009828455,0.042573765,0.059921816,0.09757311,-0.042594142,-0.07790132,-0.0018870387,-0.07278392,0.06629037,0.004876445,-0.0432753,0.06928215,0.00031821025,-0.04232126,-0.046658494,0.028597761,0.062944874,0.0083120745,0.017700948,0.023329148,0.013159454,-0.055838257,0.069176435,-0.072506346,0.02255539,0.005077847,0.009823019,-0.06306149,-0.06425466,-0.011728379,-0.09319706,-0.07560494,0.060201306,-0.09963827,0.05960445,-0.045183856,0.02656103,0.018564759,-0.006812521,0.092576146,-0.074929155,0.012449469,0.099080816,-0.071695164,0.0981975,0.011928692,-0.03380255,0.065547206,0.041073408,-0.13639298,-0.011017294,0.063445695,-0.034465868,-0.026307618,0.025647262,-0.015222279,-0.00776089,-0.008022891,-0.024942756,0.00043230207,-0.018748077,-0.030467527,0.03667369,0.020187015,0.04229571,-0.024786936,-0.07082783,0.04597465,-0.032074668,0.009900857,-0.06623191,0.013014218,-0.031125097,-0.13092577,-0.02688007,0.018633615,-0.003443203,0.0005642689,0.039134625,0.032391503,-0.022759462,-0.046837334,0.055766605,0.082204774,0.05723746,-0.06000702,-0.0021942141,0.07709214,-0.074506976,-0.0339119,-0.09277062,-0.03481143,-0.05412553,-0.009034519,-1.597169e-08,-0.03902775,0.070468016,-0.019455398,-0.009087524,0.023859533,-0.011962539,0.030921767,-0.012907053,0.0037944391,0.0391847,0.011287703,0.062478796,0.06302239,-0.01285154,0.07395657,-0.013552048,-0.017470121,0.05409657,-0.088913724,0.035792217,-0.027000815,0.04636564,0.08569034,-0.047154877,0.051179532,-0.010523361,0.058381774,0.054288268,0.009419741,0.027628561,-0.021505713,0.0030071926,-0.016405545,-0.036033046,0.047253825,0.07232611,-0.02523354,-0.029568175,0.07488461,-0.06413469,-0.02512882,-0.019198509,-0.014097056,0.09558656,0.067996286,0.012986802,0.0065120235,-0.0055387574,0.028456492,0.052861493,-0.047109302,0.06943612,0.010978891,0.05891871,0.051110785,0.030609403,0.0015038289,-0.06334439,0.03703199,-0.043403536,0.13312547,0.0719006,0.025956877,0.031312965 +4.2.1.78,"The reaction makes a six-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates. The product is the precursor of the benzylisoquinoline alkaloids in plants. The enzyme, formerly known as (S)-norlaudanosoline synthase, will also catalyse the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants.",384,1.0,-0.07133047,-0.043702226,-0.090733506,-0.029318027,-0.025866538,0.07251534,-0.09941214,0.031806458,0.12432344,-0.008682174,0.034851376,-0.030534714,0.016900547,-0.06360879,-0.10627728,0.12513506,-0.11959063,0.0074367304,-0.035436917,-0.034673315,-0.039136823,0.05609286,0.044241324,-0.017888108,0.09424231,-0.023009505,-0.0039341594,0.007917903,0.02324078,-0.03731533,0.027987253,0.022725932,0.0074780295,-0.01021833,0.014134198,0.005366473,-0.042626172,-0.005670994,0.03330444,0.060026325,-0.02805387,-0.009744932,-0.063405424,-0.0051259166,-0.019842135,-0.005907341,-0.03223438,0.040089335,0.052825924,-0.03441357,-0.007429977,-0.03989473,-0.053908385,0.028591836,-0.024818905,-0.0044066096,-0.062037736,0.078844875,-0.041732937,0.100309245,0.08926515,0.02772606,0.019616567,-0.012577207,0.009508233,0.019417956,-0.034180257,-0.018394979,0.09681622,-0.087256685,-0.011792609,-0.100267634,0.010545577,0.007662824,-0.042594083,0.05204611,-0.049090646,0.030220635,0.027056843,-0.07037797,0.0070355744,0.015851159,-0.0009153425,0.060383912,-0.015599066,0.023022782,0.003317706,0.08325853,0.089893535,0.023766354,-0.012993241,-0.037706755,-0.114711314,-0.05559719,-0.07133479,0.06263695,0.05217289,0.021180585,0.0062969886,-0.0026859308,0.08383905,0.020692945,-0.09478671,-0.09594439,-0.0056301486,0.071492404,-0.019932548,0.003915036,-0.024754317,-0.047851223,0.009778213,-0.04444591,0.016546056,0.007768768,-0.003932889,0.038715787,0.064804524,-0.004623269,-0.045623075,0.0048826323,-0.014450091,0.029517552,0.024947334,0.057457946,-0.043809608,0.06195246,-0.083765425,1.9097695e-33,0.059750374,0.098342605,0.011933858,0.03695069,0.005678039,-0.035634164,-0.06884607,0.037316408,-0.09421325,-0.080316596,-0.07916942,-0.07737262,0.022553705,-0.03575545,0.065579265,-0.041502573,0.003966292,-0.050696082,0.047848906,-0.06475934,-0.06108695,0.046849128,-0.061420016,0.0011066075,0.0037052494,0.052928027,0.015178507,0.014281737,0.0013685346,-0.048156314,-0.031137444,-0.04192248,-0.060070693,-0.0041788886,-0.011900537,0.039143387,-0.023846399,0.0011620042,-0.0094464375,0.036691833,0.067820944,0.049140804,0.007693041,-0.0049738577,0.061634243,0.0065871854,-0.07389084,0.08509323,0.047870934,0.040968884,-0.007812254,0.017133161,0.1479987,0.011975563,-0.059303604,0.013350923,-0.009655228,-0.028585784,0.03237995,0.040924013,-0.0470193,0.0017754374,-0.033991825,0.042206258,0.014371897,-0.025874106,-0.051304225,-0.020031508,-0.023528703,0.049310606,-0.049921304,-0.035975467,0.014832381,0.037843782,0.014999474,-0.02539368,-0.0992685,0.0010590659,0.0325624,-0.035057515,0.03377783,0.00028040624,0.041456014,-0.015874404,-0.02068984,0.024289716,-0.030971805,-0.044834178,-0.021696756,0.09029082,0.03938561,-0.026834087,-0.057828043,0.02449168,0.036283754,-2.7955107e-33,0.058706056,-0.09538585,0.022188175,-0.048562158,-0.0065385206,0.059820563,-0.032922167,-0.05274829,0.006390831,0.04754259,0.055356853,0.007959302,0.019510195,-0.021666652,0.0064381356,-0.079196595,0.06365369,0.15086642,0.07621973,-0.023458831,-0.04701345,0.03841319,-0.1006226,0.0440798,-0.009397888,0.03542249,0.063601464,-0.051438592,0.0032455365,0.07313593,0.037580032,-0.033295672,-0.02881898,-0.02368553,0.06553405,0.0762057,-0.005635968,-0.036099166,-0.016288696,0.0147478385,-0.03603792,0.044571884,0.025852077,0.005101364,0.068585694,-0.012681373,-0.039765734,0.05951071,-0.077710606,-0.007941577,0.095895246,-0.022530489,-0.029743847,-0.014205259,0.047361925,0.0416492,0.026611852,-0.078688286,0.011896939,-0.04363886,-0.043264944,-0.070933394,-0.03166398,-0.061688542,-0.0035143492,0.08668229,0.009897606,0.12661232,0.046835426,-0.060144953,0.06902753,0.039778113,-0.017628616,0.036692962,-0.060683332,-0.032747347,0.06807564,-0.05590192,0.017295063,-0.09060518,-0.022204774,-0.020461548,0.06170152,-0.02122113,-0.022519697,-0.05561459,0.04304527,0.13798954,0.009349034,0.08547908,0.045570415,0.039336085,-0.07957824,0.082685165,0.10074234,-4.4746862e-08,0.06903327,-0.060528167,0.04187643,-0.02056495,-0.0099232085,-0.005575207,0.0760445,0.005659769,0.020260267,-0.07028751,-0.029264038,0.049847193,-0.030919973,0.01634591,0.019238228,-0.024015566,0.02226691,0.062008895,-0.04866156,-0.0005714928,-0.042050067,0.042409524,-0.077235006,-0.036731556,0.015162546,-0.107878566,-0.0012783919,0.08039553,0.030918397,-0.012999503,0.051549308,0.022797521,-0.023669286,-0.05547721,-0.02644511,-0.052784193,0.02708475,-0.0454529,0.032660812,-0.04301772,-0.039732024,-0.03798913,-0.03194136,0.010371289,0.01982453,-0.04072659,-0.04498495,-0.0023377049,0.011596959,0.029893395,0.0058191675,0.051275596,0.054918263,-0.11660493,-0.10124033,-0.028190142,0.003896141,-0.054641623,0.0077165137,-0.12760074,-0.024507647,0.020892074,0.18733369,0.00028487862 +4.2.1.79,"The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate [2]. The enzyme can also use cis-aconitate as a substrate but more slowly [2]. Both this enzyme and EC 4.2.1.3, aconitate hydratase, are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate [2].",384,0.99999994,-0.009552457,-0.05654214,-0.0916801,-0.037303347,0.06738038,-0.03348075,-0.12045579,-0.01628395,0.014650295,-0.093406595,0.06867359,-0.11618017,-0.043789912,0.04779079,0.005862369,0.01995374,-0.043353643,-0.03960962,0.03134514,-0.006374814,0.035422057,-0.029611347,0.010640819,0.006033193,0.009050323,0.038753398,0.039860733,0.006812346,0.008685857,-0.04339178,-0.0037733216,-0.06731076,0.034449227,-0.07088504,0.036003906,0.05684083,-0.027102733,-0.0670079,0.029654205,0.041649975,0.078894444,-0.028414054,-0.027589777,-0.02103502,-0.0086769005,-0.0076879524,-0.00696665,-0.0143387085,-0.016355116,0.007462183,-0.047557037,-0.055553872,-0.03441787,0.025466109,-0.05934255,0.017597385,-0.016117742,0.0403768,-0.08757192,-0.026892027,0.05784369,-0.048444256,0.020539591,-0.012363565,0.078116134,-0.014209887,0.06698466,-0.054404274,0.011273837,-0.011205899,-0.07825132,-0.083242685,-0.011205596,0.06042567,0.0037924952,-0.025317034,0.04088741,-0.023919532,0.06170331,-0.08408638,-0.009605266,-0.0777903,0.04989293,0.04121246,0.042142354,-0.015811296,-0.053154077,-0.017447071,0.043447137,0.024598805,0.005471578,0.0470491,-0.020886028,-0.0967243,-0.013831544,0.03991783,-0.0010505412,0.07461099,-0.0069959583,-0.024179151,0.039991554,0.09900411,-0.13960348,-0.049394533,-0.0064159674,0.059364706,-0.042538285,0.09168022,0.004866231,0.07132972,-0.0009173883,-0.03969061,0.042149335,0.02257694,-0.03292273,0.12400909,-0.053444486,-0.07423177,0.008651413,0.037012137,0.003616106,-0.047440015,0.05100105,0.016152948,0.0067360234,0.042720955,-0.08117599,2.161402e-33,0.008768064,0.03130174,-0.031238785,-0.03558323,0.019494062,0.07799689,-0.058116943,0.044448648,-0.076362744,-0.07341859,-0.049725316,-0.096515454,0.09134772,0.03392207,-0.04948557,-0.06117212,0.04996852,0.029051019,0.038695086,-0.07025396,0.045102634,0.07288178,-0.009729121,-0.0026918321,-0.0075043845,0.02400744,0.035486747,0.033947848,0.055904638,-0.0049053957,-0.014430708,-0.05194369,-0.10292614,0.0030069968,0.07211977,0.07156953,-0.04273964,-0.027480992,-0.013850767,0.09665836,0.07962507,0.04554156,0.025115319,-0.047310535,0.04196215,-0.036016133,-0.037493076,0.08910243,0.012671608,0.034233253,0.007231436,0.007792005,0.023822717,-0.0033383945,-0.03709761,0.015932253,-0.054589078,-0.019521264,0.005883993,-0.045062058,-0.022551795,0.04043364,-0.023900896,0.03900072,-0.051344957,0.052946795,-0.08729595,-0.030559808,0.020555595,0.079060085,-0.026714362,0.0018385142,0.08623583,0.032000396,0.051639035,-0.07068883,-0.052767523,-0.035951685,0.013305648,-0.0015197146,-0.051604196,0.030653816,0.09177985,0.036654335,-0.08228432,-0.09554292,0.033181112,0.028098652,0.019647103,0.027393762,0.0467137,-0.030096628,-0.059356093,0.02813467,0.015719032,-3.495858e-33,0.08611643,-0.057397693,0.047916237,-0.12257432,-0.054289464,0.03849952,0.047642518,-0.008097661,0.036118846,-0.031679247,0.15158047,0.02358918,-0.01958924,-0.08689386,0.010247918,0.055721115,-0.045066208,0.054629426,0.016053079,0.045257136,0.059397005,0.009723944,-0.009858157,0.101477556,-0.012939483,-0.010850652,0.047707476,0.006745506,0.106557645,0.047507506,-0.035583254,-1.0869209e-05,-0.009977499,-0.042541917,0.0183185,0.0666122,-0.06598223,-0.02179005,-0.05158175,0.089237384,0.013181623,0.022414641,-0.043605395,0.05728804,0.018879889,0.073251195,-0.03786767,-0.019195609,-0.08849154,-0.10692807,0.031910367,-0.057040785,-0.02556493,0.08357018,0.06829609,0.054089535,-0.029179525,-0.0068352744,-0.068813115,-0.04360037,-0.0030843646,0.0034790395,-0.009923865,-0.049282733,0.080814265,-0.003253025,-0.041423038,0.041029036,0.01703257,0.035245363,0.047021605,-0.032522596,0.021445412,0.035643406,-0.025490994,-0.0891731,-0.08932014,-0.026591342,-0.017885493,-0.0753081,-0.005081176,0.023529798,0.018448327,-0.04231043,-0.0502493,-0.041116346,0.023912542,0.09483641,-0.010665817,0.025155881,-0.008066359,-0.037882313,-0.033354413,0.09135708,0.07285421,-4.5921773e-08,0.039003458,-0.055114,0.044745103,0.0055180225,-0.01963389,0.12025319,-0.055179473,-0.019896768,0.04453348,-0.01445893,-0.042504065,-0.004085641,0.040003054,-0.030730246,0.065335006,-0.027185319,0.049209926,0.06737671,-0.0329546,-0.0442082,-0.13331956,0.01724697,-0.09518893,-0.06730177,0.02850852,0.034057554,-0.031521577,0.03733448,-0.03182641,-0.040975757,-0.007136953,0.011768409,0.04092026,-0.020782508,-0.05461888,0.02590043,-0.00094754726,-0.021355327,-0.051663425,0.060513623,0.030018266,-0.029739235,-0.08000428,0.05088356,0.080901325,-0.038365487,0.029042734,-0.02511083,-0.035795756,-0.025518974,0.02361405,-0.019855134,-0.015384739,-0.03946715,0.009982579,-0.01099044,-0.096152715,-0.061833084,-0.11094038,-0.0040264404,0.116306625,0.017368875,0.13994557,-0.050899986 +4.2.1.80,"The enzyme is involved in the catechol meta-cleavage pathway, a major mechanism for degradation of aromatic compounds. Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer. The enzyme was named when it was thought that the substrate is 2-oxopent-4-enoate. However, it was later found that the actual substrate is its tautomer (2Z)-2-hydroxypenta-2,4-dienoate. In some organisms the enzyme forms a complex with EC 4.1.1.77, 2-oxo-3-hexenedioate decarboxylase (previously named 4-oxalocrotonate decarboxylase).",384,1.0,0.056267124,-0.022006543,-0.014035202,-0.015383687,0.054646168,-0.042064697,-0.07990481,0.048744023,0.029484484,-0.0051733316,0.0013226606,-0.020778958,-0.08044924,0.03250628,-0.043874823,0.04526369,-0.08417921,-0.01190208,-0.00041805598,-0.007436374,0.061557792,-0.0105504785,-0.022931451,-0.022623582,0.0044046273,0.030080391,0.022883771,-0.010449459,-0.0030887958,-0.066733494,0.071490675,-0.040772334,-0.021426613,-0.030257592,0.011381968,0.075391315,0.012154988,-0.092517324,0.0933935,0.042446207,0.038551863,-0.0007221151,-0.032914296,-0.053936407,0.032857556,-0.017184732,-0.00024157533,-0.035057295,0.044151086,-0.03917544,-0.0034131992,-0.01257295,-0.04627739,0.05663725,-0.020590648,-0.011733784,0.008248528,0.043335248,-0.12668066,0.07485687,0.09820993,-0.026280157,0.03806037,-0.011222351,0.022290437,0.0329653,0.0010892459,-0.060113166,0.0504387,-0.07695281,-0.089314036,-0.06535863,-0.029703965,0.038732156,-0.029991005,0.006287235,-0.03279061,-0.025361754,0.015506138,-0.026877776,0.078249924,0.06427519,0.05546936,0.02178625,0.039806217,0.0073620495,0.03102812,-0.04193066,0.06202567,0.060984552,0.03466895,0.00030990926,0.0025582407,0.03205369,0.014763559,0.03543445,0.024618778,0.085010864,-0.0009058922,-0.022574231,0.03760113,0.041573,-0.086498134,-0.114070475,-0.022613669,0.047784667,0.03928445,0.040233973,-0.008082825,0.006557868,-0.054513484,-0.06712496,0.055989444,-0.014039275,-0.026305493,0.12966496,-0.00933144,-0.009265381,-0.0068037766,-0.02299646,0.0264731,-0.004243506,0.036378432,0.040409498,-0.018018123,0.05649387,-0.10796149,-5.2462184e-34,-0.029283227,0.03848441,0.01898904,0.026954096,0.032573596,-0.03362182,-0.06737964,0.06556033,-0.07058806,-0.046147566,-0.064647205,-0.060890228,-0.00016536276,-0.052884046,-0.011551772,-0.093192816,-0.05831974,0.07828359,0.050495923,-0.01019076,0.02223713,0.053955358,-0.048866156,0.021097451,-0.032788076,0.029272968,-0.004629983,-0.024113903,0.028400717,-0.028044527,0.01138919,-0.1146269,-0.08802774,-0.011800548,0.044010315,-0.046616547,-0.0059686373,-0.011448938,-0.043691475,0.069997266,0.032086805,0.008913951,-0.0050811716,-0.041210987,0.055928335,-0.07170921,-0.025098339,0.058293503,0.07933372,-0.035835557,0.006215355,-0.06430924,0.036982924,-0.0008030932,-0.04369621,-0.01692908,-0.052287567,-0.0001119248,0.069410376,0.015874013,-0.0145515995,0.02702005,-0.075432256,0.034810822,0.0419547,0.013084618,-0.053723667,-0.044596612,-0.037373744,0.09889433,-0.04785757,-0.0047423667,0.072567776,-0.027413715,0.11757534,-0.0479729,-0.09536177,0.016836332,0.06413077,0.014344085,0.010633825,0.032648858,-0.019497855,-0.039490107,-0.07243535,-0.02626947,0.038443223,0.003146292,-0.013744745,0.12478248,0.01970339,-0.023731505,-0.06530877,0.008474762,0.04776807,-1.2639833e-33,0.08068736,-0.06675198,-0.00044142225,-0.056054253,-0.046406325,0.07987718,0.005211835,0.0029711055,0.057204075,-0.01660744,0.12017557,-0.0060223974,0.06576887,-0.049407654,0.034381267,-0.019669013,-0.047123246,0.046711702,0.011902376,-0.029326962,0.07173646,0.061156284,-0.031919487,0.05311128,0.052897353,0.0066615697,0.058634922,0.055740528,0.09167902,0.07262374,-0.011008385,-0.008265383,0.001715788,0.05160468,-0.082089484,0.08652416,-0.05996511,-0.026793368,-0.02338798,0.033570338,-0.027932087,0.0025008365,-0.0061352174,0.038765073,0.032204438,-0.0010777016,-0.1480559,0.08401641,0.050099645,-0.052759923,0.021005018,-0.02062876,-0.07807224,-0.012957829,0.07384519,0.08707669,-0.09646368,-0.021986794,-0.024861192,0.040394977,-0.0073549245,-0.06474294,0.037326735,0.01290847,0.04554082,0.0032302444,-0.054210443,0.008925761,0.03242657,-0.064568006,0.10299117,0.023349864,-0.02784816,-0.017971,-0.012731412,-0.036057126,-0.06832262,-0.046890825,-0.05480979,-0.031996686,-0.021316899,-0.031276323,0.044807956,-0.1360181,-0.027520454,-0.09498722,0.013981344,0.15718827,-0.046163414,0.056182317,0.010136971,-0.050902355,-0.083011605,0.054181796,6.00783e-06,-4.4392745e-08,-0.026782649,-0.050602697,0.051330496,-0.021121215,-0.035100363,-0.0018251283,0.06157302,0.0002672731,0.06443382,-0.06828644,0.061505973,0.031057756,-0.010341715,0.034799457,0.10155281,-0.016274007,-0.035583306,0.06250674,-0.022490622,0.039590027,-0.023504626,-0.09995576,-0.09194506,-0.02603121,0.011371858,-0.028206961,0.042039014,0.11820178,0.012121866,-0.023787007,0.020940553,0.01574691,0.09276287,-0.009500063,-0.07160334,0.004624769,-0.073028564,-0.027702088,-0.050781786,0.024861561,0.010873841,-0.09124665,-0.05855469,0.026826307,0.065602325,0.04572561,0.030341815,0.040723298,-0.025299417,-0.021384565,0.055892453,0.00019092951,-0.014773914,-0.017254781,-0.061024394,0.04465011,-0.043216,0.000736209,-0.028318912,-0.07940495,-0.000589058,0.021461297,0.20225635,-0.0070046945 +4.2.1.81,Requires Fe2+ or Mn2+. cf. EC 4.2.1.32 L(+)-tartrate dehydratase.,384,1.0,-0.0243639,-0.0189904,-0.062358335,0.002067397,0.11992126,-0.065338805,-0.02137947,0.028442139,-0.048106376,-0.07551453,0.016109705,-0.12350168,-0.04476907,0.025927985,-0.03335812,-0.03881504,-0.063203,-0.055676695,0.03140639,0.047983576,0.09933127,-0.028678125,0.016777903,-0.064227834,0.042372555,0.03591065,0.028135635,-0.010465005,-0.032020915,-0.1007446,-0.01673685,0.04404003,0.004498763,-0.08237275,0.06291318,0.103198394,-0.048662566,-0.026876321,-0.041331846,0.016946135,0.018985592,-0.020309553,0.03556498,-0.02460784,-0.034985747,-0.059797946,0.06788608,0.015107736,0.04259431,0.032081604,-0.0707616,-0.007137057,0.008547665,0.0417317,0.014088016,-0.06077217,-0.020863324,0.032301378,-0.04071187,-0.057902563,0.0061944528,-0.004861775,-0.010916062,-0.026468962,0.06456134,0.016234025,0.038994346,-0.0271741,0.0003879295,-0.007074479,-0.017694157,-0.021100245,0.0038579542,0.051411256,-0.037009828,0.02534629,0.045338873,-0.0043193493,0.060899828,0.017571138,-0.07626936,-0.0012685696,0.024471233,-0.013308037,0.05909927,0.03533281,-0.03326666,-0.04067823,0.0003783646,0.0048005027,0.022932284,0.028763715,-0.066901155,0.042847373,-0.015135939,0.05624612,0.028697994,0.06266513,-0.018433468,-0.02425053,-0.05742448,0.10986672,-0.076845825,0.016583929,0.02734189,-0.032706548,0.07164389,0.07120558,-0.037194323,0.0015552253,0.069086686,-0.013525225,0.04070234,0.07750552,0.018693827,0.058859598,0.0036543633,-0.07688025,-0.05228333,0.016380167,0.07652583,0.030405506,0.008958912,0.045162655,-0.04924505,0.012981585,-0.07850653,1.8184413e-33,0.09160468,0.021195156,0.05598019,0.044964783,-0.0010240374,0.048425835,-0.104894646,-0.022620039,-0.008103139,-0.011959446,-0.10449598,-0.08811377,0.04108707,-0.012251191,-0.11294583,-0.09307475,0.06525876,-0.06095363,0.062056877,-0.0034018885,0.089293785,0.04838381,-0.019163977,-0.03159516,-0.07255375,0.10368096,0.06707407,-0.016410645,0.09559524,0.02311251,0.031712174,-0.12311377,-0.01254527,-0.022150155,0.0400746,0.0007131562,-0.09972671,0.0021702787,-0.045215946,0.03592745,0.035817426,0.06848446,0.018737504,-0.053015005,0.05122879,-0.029364765,0.04857379,0.11781687,-0.024821945,0.085723534,-0.026799263,0.031873938,0.013888165,-0.0651997,-0.058570094,-0.025011081,-0.016323538,0.0035273645,0.0095865745,0.061480302,-0.0070510036,0.11918615,0.022924924,0.034674324,0.030687643,-0.0022437493,-0.0779884,-0.023745947,-0.009215005,-0.0024709927,-0.035129786,-0.07905153,0.1462236,0.069101624,0.044651296,-0.025592068,-0.022660205,-0.065809675,0.008685162,-0.02781383,-0.036872875,-0.029896557,0.0039940416,-0.03192749,-0.020595465,-0.0035116922,-0.042251967,-0.001686462,0.010249891,0.041301,-0.032175932,-0.020706156,-0.013254933,-0.07254865,0.0065838406,-2.1476475e-33,0.055451196,-0.07322991,0.021155005,-0.061857283,0.015554279,0.046740882,0.056750983,-0.108856454,0.06518348,0.036939647,0.08385755,-0.02051421,-0.009524832,-0.06823748,0.020372922,0.10766098,-0.036289312,0.0033141135,0.04024009,-0.008924027,-0.028540112,0.15770234,0.015571348,0.11436432,0.02098967,0.034752008,0.053826462,0.010408189,0.024024742,-0.021999845,0.012858801,-0.000121208584,-0.050152186,-0.059130166,-0.09068446,-0.0015421374,-0.033740077,-0.04897815,0.011580295,0.022962015,0.004063929,-0.039127234,-0.02031261,-0.0014166506,0.00039543063,-0.03970246,-0.016124886,-0.0318782,0.0043622428,0.046770584,0.048100065,-0.080770664,-0.05165143,-0.015703946,0.02404337,-0.0022368077,0.06565728,0.08169688,-0.04568841,0.014395241,0.01834938,-0.026419023,0.07110282,-0.08535129,0.021409476,0.007804325,-0.0062176515,0.08053298,0.03722123,0.051342275,0.03325938,0.04713421,0.06320978,0.023931859,0.007610649,-0.015883109,-0.0927692,0.029634457,0.031857092,-0.11910517,-0.03661427,-0.014974485,0.016226662,-0.044096526,0.067342184,-0.11158758,0.027840618,0.043500107,-0.013505194,0.04604959,-0.032877978,-0.10552353,0.00019425242,0.13317078,0.046774156,-2.9026966e-08,-0.031884924,0.0048348517,0.0026267546,0.009385527,0.007901433,-0.0184755,0.051696632,-0.026968963,0.003961503,-0.06751767,0.012933854,0.062289383,0.07306338,-0.0062945634,0.046925727,-0.031435188,0.03662344,0.0678789,-0.060007118,-0.065319404,-0.022671103,-0.07879931,-0.13158706,0.0397304,0.069648914,-0.034738395,0.02306995,0.004882808,0.039434906,-0.09003459,0.015878862,0.034845702,0.02733751,-0.08873385,-0.012871406,0.048779283,0.021325385,-0.014018363,-0.024912206,0.03580385,-0.0726851,0.047190696,-0.04542892,-0.025987059,-0.012128236,-0.030929465,-0.07902472,0.057195473,-0.032151617,0.012410157,0.073406644,-0.027889822,0.014541469,-0.013480967,0.011038636,0.06125764,-0.036898557,-0.014322641,0.0031378649,-0.06679909,0.10147457,-0.019081049,0.069578394,-0.09287719 +4.2.1.83,"This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), syringate and 3,4,5-trihydroxybenzoate, catalysing the reaction in the opposite direction [1-3]. It accepts the enol-form of 4-oxalomesaconate, 2-hydroxy-4-carboxy-hexa-2,4-dienedioate [4].",384,1.0,0.06732454,0.012984612,-0.09256931,-0.05454887,0.05046907,-0.03150303,-0.013854186,0.036863554,-0.018872263,-0.016996797,-0.043488193,-0.015856402,-0.05535811,0.020423016,-0.07273773,0.11202335,-0.038726635,0.011693777,0.014005811,-0.0152063435,0.03439412,-0.033949655,0.0371143,0.0037432273,0.023983942,0.03170033,0.04267001,-0.0067194393,-0.072572075,-0.096786685,0.040469617,0.009620077,-0.021507436,-0.03677196,0.03372682,0.07914431,-0.030133933,-0.06794547,0.022968885,0.02586312,-0.013771206,-0.0032354118,-0.07969324,-0.01128406,-0.02591606,-0.057965066,-0.047404554,0.050366513,0.066920325,-0.028374026,-0.076547876,-0.027439544,-0.0126712,0.067703106,-0.0455666,-0.014521653,0.021087216,0.008910594,-0.084300846,0.073260516,0.06551317,-0.020190965,-0.040888842,0.05592796,-0.040198304,0.00014325316,0.030293366,-0.05528124,-0.043120988,-0.01508911,-0.0790979,-0.05954379,-0.0015083066,-0.038078386,0.018607115,0.01432461,0.002377312,-0.040625546,0.020484632,-0.032231797,0.041495055,0.058320966,0.041328028,0.053840153,0.007956897,0.03486883,0.024339026,-0.04724317,0.09264857,0.08588115,0.024861323,0.02807223,-0.019581111,0.034672648,-0.06430749,0.07645568,0.032081652,0.052462842,0.04565604,0.021054093,0.083326824,0.027348977,-0.06285838,-0.12081182,-0.020690536,0.05395139,0.026581012,0.096232876,-0.004483267,-0.0007470222,-0.08949085,-0.061019376,0.075821765,0.022292582,-0.0748093,0.1527363,0.03170372,0.009580345,-0.041205637,-0.026971044,0.055613745,-0.008878118,0.029250214,-0.031048719,0.0062293224,0.021845745,-0.09299831,-3.1950047e-34,0.041827723,0.07964472,0.0060476717,0.043887433,0.010069672,0.021095566,-0.08942028,0.03095854,-0.09362418,-0.006756023,-0.12555085,-0.029795531,0.02093936,-0.04232184,-0.040258877,-0.05318295,-0.07948755,0.037205968,0.037603874,0.03167781,-0.0020315743,0.03408217,-0.102156945,-0.0095191505,-0.05037228,0.13081685,0.037875954,0.028603328,0.0008482059,0.00047793874,-0.013554125,-0.0716374,-0.08812548,-0.014345717,0.049608245,-0.042747665,-0.024136674,-0.012832863,0.014888315,0.03984998,0.055232912,0.030662036,-0.021891836,-0.019685924,0.06805126,-0.08156912,0.014627791,0.15282317,0.067928046,0.031254284,0.04759117,-0.0621236,0.08967562,-0.008687123,-0.054589797,0.04427817,-0.034646206,0.023643363,0.05561766,-0.028760144,-0.015193638,0.013987545,-0.044364974,-0.0023980439,0.0032623047,-0.041371472,-0.012458901,-0.0436959,-0.040571157,-0.021215634,-0.076762505,-0.013514304,0.0336568,0.06544175,0.041893564,-0.0792879,-0.02301254,0.002540485,0.05808322,-0.017748479,0.0033620456,-0.022669913,0.001367958,0.0018183454,-0.004886097,0.012407564,-0.018746339,-0.034904584,-0.04018993,0.082204625,0.06289875,-0.102491245,-0.041311145,0.018921826,0.07667093,-9.998862e-34,0.071813926,-0.039877623,0.017576464,-0.06277903,-0.046209604,0.007215505,-0.012454426,0.028008135,0.016722215,0.027660856,0.06545723,-0.029680742,0.07597613,-0.049734354,0.020338219,-0.02091411,0.026925202,-0.045273047,-0.06754639,-0.052932896,0.028184924,0.09465286,-0.014327252,0.0017513831,0.0036749642,0.027862178,0.023839654,0.0073412694,0.08482406,0.06312025,0.018029455,-0.023894873,0.023002278,0.022441396,-0.01584537,0.067876026,-0.048965726,-0.024306769,0.025213977,0.05094638,-0.07418501,0.0014530068,0.021755926,0.031157866,0.04837997,0.06292484,-0.14790612,0.06683759,0.0054849028,-0.053679444,0.0075772693,0.023764597,-0.06783797,0.015163514,0.06722864,0.03376971,-0.0017035343,-0.078906894,-0.044339072,0.0060549392,-0.032328404,-0.011689432,0.09249989,0.01524659,0.038215403,0.055171166,-0.039371554,0.049919307,0.021624822,0.00023535552,0.1014996,0.00075907964,-0.079928696,0.018334303,-0.007963573,0.011420333,-0.06285013,-0.03831986,-0.06526173,-0.013646726,-0.00071169436,-0.038183138,0.04583625,-0.0833377,-0.08780398,-0.16950269,0.03715038,0.10969051,-0.063160114,0.07265034,0.04215551,0.027785009,-0.052491225,0.06820006,0.01764662,-4.1684128e-08,-0.018865427,-0.065597594,0.05787054,-0.061086863,-0.035564493,0.05079845,0.035963975,0.047538947,0.11128794,-0.0761694,0.028171752,0.055133604,0.024586434,0.059074074,0.057125952,-0.004160605,0.00023414243,0.04339582,-0.051181246,-0.007119615,-0.056064963,-0.04356227,-0.07778318,-0.014951728,0.047726903,-0.036558334,0.03728899,0.06479998,0.031010771,-0.03134466,-0.03749388,0.072865576,0.04706739,-0.035750516,-0.11049182,0.056984115,-0.05303798,0.008892244,-0.04590301,0.028342636,0.048552025,-0.024337865,-0.0847585,-0.010287761,-0.0032236946,0.006898879,-0.005502168,0.02450801,-0.013846455,-0.0023292282,0.0061612623,-0.023694217,-0.024250284,-0.053032894,-0.07566812,0.02402141,-0.034281664,0.018678084,0.007752176,-0.09122687,-0.04990569,0.023961378,0.15832235,0.007029168 +4.2.1.84,"Acts on short-chain aliphatic nitriles, converting them into the corresponding amides. Does not act on these amides or on aromatic nitriles. cf. EC 3.5.5.1 nitrilase.",384,1.0,-0.010986649,-0.08885435,-0.0077603087,-0.050135247,0.009481235,-0.05429278,0.029805345,-0.08466601,0.022530563,-0.06452009,0.0012679028,-0.03217016,-0.029056702,0.054006483,-0.00799095,0.0008593114,-0.08440065,-0.072323635,-0.0066859648,0.016189963,-0.025758354,0.05324117,0.04568372,-0.0505298,-0.021498017,-0.023249118,0.0459943,-0.038165733,0.026109507,-0.108669356,0.03326927,0.030376738,-0.06018618,-0.04873045,0.07528702,0.05928959,-0.07287285,0.022246588,-0.0056026024,0.0008874263,0.104396835,-0.044856068,0.017068978,-0.02777608,0.0142002115,-0.032389224,-0.031878907,-0.048461713,-0.0006185484,-0.024492482,-0.0556097,-0.041513283,-0.012517856,0.06337587,0.03337071,0.01251267,-0.109289974,-0.008761536,-0.03454733,0.022985497,-9.8905504e-05,0.008062641,-0.03195256,-0.054459766,0.0016683129,0.07348273,0.078982085,-0.06695263,-0.019871805,-0.0046362313,-0.09809015,-0.0712772,-0.032761898,0.05245461,0.056928292,-0.043702114,0.010764793,-0.037197065,0.022402804,-0.08771329,-0.04032316,0.03159633,0.06452654,0.019783387,-0.00034221873,0.005229411,-0.105971076,-0.018054662,0.036894333,0.00084683235,0.00015357509,-0.03691036,-0.011021945,0.011767411,-0.0044868463,-0.043680117,-0.033531405,0.09008093,-0.056308094,0.02114346,0.05230258,0.04943413,-0.15572245,-0.045527216,-0.13853303,0.07161638,0.018528806,0.0025869608,-0.019353848,0.05914673,-0.007816105,-0.025646117,0.065596074,-0.06863242,-0.08108419,0.024245428,-0.013198409,-0.040109374,-0.05556472,-0.04898261,-0.015878592,0.043496065,0.0016159039,0.058852855,-0.10196927,0.07849443,-0.034504585,1.7074988e-33,0.0062482604,-0.0029335076,0.008063789,-0.021340108,-0.03827047,-0.002649259,-0.085149445,-0.04647524,-0.03873415,-0.11251176,0.046950556,-0.03573562,-0.032583784,-0.063161656,0.058149595,-0.044211406,0.072050035,0.069114424,-0.021231657,-0.002664639,0.0072851665,0.095905714,-0.11251691,0.010428006,-0.0183207,0.029004717,-0.020605149,0.0521284,0.029212905,-0.04609211,0.02492892,0.0031769937,-0.033999216,0.05816591,0.028097926,0.06900263,0.0027573777,0.07314075,-0.010467313,-0.0026658266,-0.06557068,0.0930561,0.011456546,-0.017697087,-0.038814973,-0.01566547,-0.00032732487,0.124856375,0.07954764,-0.015227734,0.036318354,-0.052120883,0.08771911,0.015803514,-0.010091351,0.08931122,0.011856105,0.0022674443,0.05177408,-0.019266726,0.0026004363,-0.10364068,-0.014316094,-0.034326676,-0.036394272,0.068612516,-0.07274427,0.040495846,0.04283406,0.10712582,-0.03397953,0.091923065,0.035980765,0.06806832,0.121482655,-0.05558459,-0.08884194,-0.0048211017,0.048837982,0.082229815,0.06505817,-0.0115119675,0.0315218,-0.004567413,0.0016523908,-0.0007409939,0.0058664745,-0.03511052,0.010474901,0.033835314,0.011808065,-0.06866239,-0.032553487,0.007376571,0.019828593,-3.3860192e-33,0.10971645,0.0038854736,-0.07308788,-0.004277286,-0.06118948,0.035831414,0.026699478,-0.017498875,-0.008125815,0.013136231,0.10177497,0.01675148,0.0036483766,-0.053611774,0.031225817,-0.08801043,0.024902135,0.018495644,0.026298817,-0.01371269,-0.0026060846,0.01049179,-0.08897672,0.019383956,-0.008829851,0.037209686,0.007042889,0.05712061,0.08428503,-0.015019395,-0.033609293,-0.005964148,-0.083941065,-0.06379494,0.0069188112,0.02501575,0.040771104,0.0072860415,-0.1177563,-0.07512413,0.055352725,0.046415474,0.054986767,0.16220166,-0.0077123153,0.024148988,-0.059110973,0.035311017,-0.06964015,-0.06352088,0.0015059847,0.04156568,-0.008009229,0.0003081208,0.015637916,0.07353129,0.06784206,-0.015573257,0.041962642,-0.07075041,-0.09400879,0.0054662684,-0.0023382995,-0.08132363,0.022166627,-0.014606789,-0.09016407,0.055321984,0.123982504,-0.05533735,0.032232087,0.003307362,0.092506714,-0.03543084,-0.028248115,-0.06288498,0.03382374,-0.05729737,0.06262914,-0.06645305,0.09718004,-0.056683995,0.013432738,-0.032599103,-0.024072768,-0.02223638,0.10092809,0.030139485,-0.06954541,0.026639681,0.040989224,0.04458823,0.06189362,0.064891234,-0.07416765,-3.4729624e-08,0.017335892,-0.016965268,-0.0076980884,0.0319197,-0.057768673,0.013600306,0.019113796,-0.026438577,0.012793417,-0.01387375,-0.0043183207,-0.0020517001,-0.006127929,0.0014471676,0.043516193,-0.038710736,0.014773526,0.002257051,-0.055665925,-0.009078077,-0.126843,0.042462748,-0.09980605,0.028355915,-0.03637603,-0.022271138,0.04318516,0.018228862,-0.0003108798,-0.03697756,-0.04430701,0.08041749,0.04380384,0.0018635136,0.0111004375,0.013159856,0.021790769,0.0098407725,0.03742985,-0.01173689,-0.023536405,-0.025305022,-0.018079745,0.017298285,-0.02695454,-0.0012440095,-0.031497452,-0.014378994,0.07249805,0.055109054,0.058449473,-0.032259397,0.08466225,-0.037634194,-0.08395539,0.021320328,0.0069688484,-0.008394789,0.058619495,0.0055637327,0.087343946,-0.01528418,0.07735275,0.062114157 +4.2.1.85,Requires Fe2+. Inhibited by oxygen.,384,1.0,-0.0066580125,-0.0039542816,-0.03720076,0.12603603,0.12667315,-0.05626967,0.015202928,0.0017298518,-0.017571753,-0.04315794,-0.018827427,0.012548171,-0.067627355,0.053579733,-0.00929123,0.009022336,0.0009125995,-0.01208863,-0.010916275,0.047167096,0.073052354,8.4787804e-05,0.0803874,-0.06993726,-0.10886925,0.043415856,0.00724151,0.008237305,0.02329826,-0.054746658,-0.030051762,0.015972748,0.041187607,-0.06051312,-0.054144517,0.051124398,-0.018401686,-0.021346333,-0.072165,0.0030258829,-0.06694871,-0.06815933,-0.017223658,0.0131931575,-0.01998311,-0.08900109,0.07336839,-0.07129024,0.049494386,0.03618343,-0.07571169,0.0021648775,-0.060246047,0.03983616,0.023495251,-0.03044096,-0.012194874,-0.011959388,-0.022907417,-0.07083693,-0.028466996,-0.042833067,-0.038394608,0.047368318,0.05210339,-0.002214362,0.037929647,-0.024846964,-0.050847325,0.033171993,0.032091316,0.0045574727,-0.046434607,-0.026470017,-0.05142152,0.04749237,0.078623794,-0.094900906,0.14415184,0.050235152,-0.053921346,-0.030928528,-0.0003956678,0.06712405,0.060242612,0.08462888,-0.022707667,-0.06160432,-0.13603595,0.06924768,-0.012994463,0.055381242,0.017188672,0.04243693,0.023436066,-0.005448698,0.056699377,-0.000444955,-0.07868097,4.6834443e-06,-0.075424194,0.09794979,-0.06404935,0.0085598035,-0.04722967,-0.037245158,-0.0062312144,0.059320148,-0.00028936792,0.03634373,0.07045849,-0.041381203,0.04566058,0.022508603,-0.016859332,0.066401444,0.020715095,-0.039373267,-0.031389046,0.03697432,0.04497645,0.009820903,-0.029345963,-0.006153975,-0.058884468,-0.07806574,-0.03781823,-9.498102e-34,0.05984304,0.024477383,0.026376165,0.0512903,-0.042275146,0.0046995063,-0.114560455,-0.067793466,0.011212006,0.024204047,-0.05490359,-0.06563792,0.031199867,-0.022117736,0.009639027,-0.10986867,0.016125938,-0.031610582,0.062565446,-0.024447193,0.06291013,-0.0040702345,0.011509358,-0.046314344,0.022170695,0.065999806,-0.023269774,-0.029421724,0.0016493954,0.014996404,0.047459397,-0.044694033,-0.078868814,0.011439739,0.026261238,0.028642833,-0.051915843,-0.0017361587,-0.037397448,-0.00040336687,-0.013479635,0.08035586,-0.036925644,-0.026701871,0.102162525,-0.09940862,-0.01594818,0.12888277,0.016762981,0.11283154,0.02238208,0.016745798,0.0199127,0.012572008,-0.017783081,-0.028315669,0.0055344263,-0.046014883,0.0064097526,0.08186428,-0.0014251817,0.03786803,0.042446557,0.09778771,0.03283721,0.017096752,-0.067187116,0.032980565,-0.031416453,0.044151574,-0.064130075,0.0048582633,0.09105311,-0.020013789,-0.02239702,-0.053516883,-0.030042503,-0.025795432,0.058395408,0.005908028,0.059788562,-0.086791955,-0.01491179,-0.020897383,-0.053655956,-0.0045178067,-0.09276114,0.04239655,0.031522494,0.007562032,0.070965864,-0.085337915,-0.012547418,-0.073638275,0.0013132443,-3.4390706e-34,0.048155505,-0.072334036,0.016627086,-0.04114929,0.0066803894,0.06526853,-0.026261255,-0.14747569,-0.003327922,0.015204199,0.025064725,0.022771014,0.02650077,-0.06664881,0.03203328,0.04918296,-0.0751187,0.03424205,0.0537236,-0.0092298025,-0.009518441,0.0943807,0.009967517,0.081927,0.049885113,0.041407682,-0.064109094,-0.018005121,0.03121979,0.04859941,0.01951753,-0.0030183028,-0.09597114,-0.05374201,-0.024653416,-0.031572074,0.010161806,0.04074009,-0.019317955,-0.00819162,0.010902941,0.029084053,0.05152126,0.12736477,-0.014485323,0.036868367,0.017878737,-0.045416214,-0.020272559,0.050834436,-0.013418546,-0.06043463,-0.13927947,-0.018522833,0.058389165,-0.023779515,0.045712046,0.022169331,-0.020983493,0.011278865,0.072484,-0.011606191,0.056287557,-0.04173381,0.024036385,0.014663829,-0.002478378,0.17259416,0.07369287,0.02133178,0.07618624,0.07106269,0.07973327,-0.048800554,-0.0006094536,0.029268656,-0.0126453135,0.013930715,-0.01576288,-0.008012013,-0.051215053,0.04051349,-0.019849509,-0.057585213,0.028161852,-0.10158324,-0.012707222,-0.022061571,-0.029641507,-0.0075114025,-0.055263005,-0.027588205,0.022194196,0.03386988,-0.02667256,-1.7044608e-08,-0.06849985,0.0050482373,0.06542086,-0.04751916,-0.019632429,0.038064297,0.07125515,0.0086625125,-0.025732,-0.03178884,0.016344827,0.10315188,0.13687831,-0.0054313345,0.095310844,-0.037979435,-0.0017355102,0.05733872,-0.05864948,-0.06720617,-0.08592967,-0.06598256,-0.06870927,0.06568445,0.0072594937,-0.056178704,-0.010244895,-0.019696128,0.06946598,-0.026212566,-0.021103498,-0.0068601607,-0.01805424,-0.048958123,-0.08589718,-0.005439388,0.07077363,-0.008105339,-0.056448426,-0.029848557,-0.05915305,0.044769343,-0.03493277,-0.008708068,-0.00024905344,0.008837053,-0.023243926,0.014135657,-0.064387806,0.031113144,0.046398558,-0.038386468,0.03171011,-0.011764753,-0.033960253,0.07791084,0.0031019673,0.028431758,0.07193136,-0.050949164,0.028317032,-0.00636771,0.110371046,-0.044884183 +4.2.1.87,"The enzyme-catalysed reaction is believed to be dehydration to an enamine, which is spontaneously hydrolysed to an aldehyde and ammonia.",384,0.99999994,-0.01695095,-0.008008155,-0.008550947,0.019823506,0.07142764,0.00038583233,0.011483819,-0.014471982,-0.026107559,0.09669869,-0.043315947,-0.055671263,-0.046579707,0.04858486,-0.06963673,0.04281583,-0.05246353,-0.040878072,-0.01059764,0.022517467,0.0700486,-0.009380635,-0.06700749,0.02728787,0.092057414,0.080014326,0.09757869,0.007132353,-0.0032562052,-0.032190703,-0.01251615,-0.018461842,-0.03258437,-0.084537975,0.04922923,0.090244524,-0.04683572,-0.01893411,0.010513267,-0.012128456,0.020533254,-0.004318892,-0.070060365,-0.07545332,-0.049448628,0.005665277,0.006079456,0.052225746,-0.04884354,0.03292443,0.027791979,-0.008114148,0.0068955948,-0.009079578,0.036549594,-0.021341175,-0.061142482,0.018931424,-0.12912889,-0.010058491,0.020890763,0.020683644,-0.065835625,-0.00069354934,0.10061985,-0.066799164,0.014776566,-0.02410851,0.041071534,-0.035527784,-0.025844889,-0.07662384,0.002494675,-0.035016134,0.0015846884,-0.08953989,-0.010760248,-0.018193973,0.014775841,0.011340503,0.05099201,0.034015212,0.05107981,0.013175556,0.03108916,0.056941524,0.0118619045,0.021123918,0.06366425,-0.025817335,-0.08708472,-0.037707172,-0.040681794,-0.02030021,-0.024395222,0.049644157,0.035534706,0.014654159,0.08136814,-0.01819854,-0.00863507,0.08550515,-0.037705746,-0.091558434,0.01942544,0.006907329,0.09533947,0.1227057,0.020561865,0.0206329,-0.031793356,-0.013121072,0.1213048,0.08381449,-0.027424907,0.085858986,-0.00011111692,-0.017105231,-0.05846596,-0.051180854,0.05101103,0.053762004,0.041392297,0.07261525,-0.022258984,0.07665982,-0.08609158,-2.1316352e-33,0.029322937,-0.06391224,0.020977182,-0.0045439955,-0.00077150203,-0.0013626554,-0.098377705,0.107071504,-0.009424183,-0.018509878,-0.05974055,-0.07008104,0.10275607,0.006786197,-0.027191255,-0.03838225,-0.052091748,0.0059370315,0.063080736,0.045693,-0.0032790774,0.055028163,-0.06407636,-0.0010716628,-0.06700559,0.012705551,0.0030685966,-0.0064706323,0.042037025,-0.027551172,0.05048471,-0.066062324,-0.09260782,-0.013753071,-0.005484227,-0.023856675,-0.025549637,0.023772372,0.033623815,0.0427983,0.03806113,0.030360822,0.011354302,-0.07078305,-0.034485023,0.0075669787,-0.020663107,0.054523084,-0.0041580065,-0.037226424,0.097020105,0.010021131,0.05757407,-0.05860118,-0.10657267,0.018927155,0.06674182,-0.027879285,0.011637484,0.102501184,-0.05334404,0.037504427,-0.031940755,-0.0044976263,-0.04433239,-0.08472468,-0.0145426765,-0.04044852,0.037504558,-0.018352808,-0.11114991,0.029327901,0.07229879,0.012161385,-0.01681772,-0.06403981,-0.025114922,-0.023040343,0.007594444,0.019911623,0.007075394,-0.04511926,-0.022709819,0.021759346,-0.024745308,-0.030240048,-0.06919069,-0.056197397,-0.038051307,0.08959611,-0.021769613,-0.056530688,-0.042182446,-0.06660462,0.078404844,-1.1297723e-33,0.100060076,-0.07193475,-0.07035098,-0.012889093,-0.027146555,0.04254233,0.0074297516,-0.0013663684,0.0065531773,-0.017705986,0.075357966,0.011582396,0.045533326,0.064206116,0.046822034,0.03149931,-0.033304922,0.026056582,0.05624879,-0.06298059,0.028257929,0.09692445,-0.021079151,-0.044034082,0.09551697,0.04008376,0.06510657,0.02682418,0.049521547,0.07079468,-0.017371044,-0.06780211,-0.02995355,-0.023339426,-0.020033067,0.11941624,-0.023933547,-0.07804182,-0.04811736,0.0064575197,-0.009447417,0.008444455,0.030987354,0.07224805,0.052564956,0.0044022566,-0.12364545,-0.015246531,-0.0061178776,0.054622933,0.091979705,-0.009056844,-0.022255098,-0.019001514,-0.0131658465,0.009303011,0.040675353,-0.022813156,-0.0015756672,0.026321191,-0.02895879,0.012827456,0.025039904,-0.051076896,-0.089301445,-0.010135651,-0.033525515,0.053789616,0.065510884,-0.06152207,0.052388884,-0.0075566135,0.020677088,0.096223235,0.044747714,-0.047902353,-0.006906702,-0.046857584,7.9977865e-05,-0.119304925,-0.018059298,0.018572912,0.031988002,-0.017287113,-0.0077188653,-0.07840262,0.01383215,0.039785646,-0.05266016,0.04426828,0.018088503,-0.0670183,-0.012340664,0.13388513,0.062383868,-2.609402e-08,-0.027556615,-0.10412407,0.024464712,0.023074511,-0.04474339,0.061337177,0.08777185,0.008213384,0.035141535,-0.11880219,0.007337473,0.045321092,-0.019055396,0.087661594,0.02042032,0.023131488,-0.026377352,-0.025583755,-0.088407435,-0.07958679,-0.072241575,-0.0040914826,-0.13193999,0.042776335,-0.0121218655,-0.027395273,-0.046204284,0.0012092743,0.0068680956,-0.033969253,-0.006117731,0.07977632,-0.0052540773,-0.030420484,-0.029766938,0.017590998,-0.018536167,-0.02432148,-0.038173888,-0.06235081,-0.01026182,0.010365104,-0.07664538,-0.022452168,0.027790343,-0.013296978,-0.03851253,0.010058334,0.030892277,0.046315573,0.071675144,0.010749774,0.052023314,0.002281151,-0.0621283,0.012289915,-0.07602745,-0.09734478,0.03587078,-0.027986515,0.05033561,0.080657706,0.17367107,-0.03618393 +4.2.1.88,"Removal of H2O from (R)-synephrine produces a 2,3-enamine, which hydrolyses to the products shown in the reaction above. The enzyme from Arthrobacter synephrinum is highly specific [1].",384,1.0,0.003235079,-0.018479018,-0.05497584,-0.013818415,0.08175038,0.010486485,0.033567708,0.0026827108,-0.0011322374,0.045413952,-1.9348025e-05,0.07420552,-0.022020467,-0.0037289641,-0.0036959092,0.0826636,0.003988568,-0.07471964,0.030118506,-0.010682849,0.0761614,0.009318207,-0.050995298,0.00012356328,0.021498606,0.054441668,0.04075258,0.048990197,-0.01586614,0.0046802936,0.031138161,0.009312685,0.013618013,-0.08471203,-0.020848777,0.018125927,-0.11900522,-0.048230205,0.05632255,0.041364577,0.060124908,0.001262839,-0.07128234,-0.08495668,-0.03276602,-0.015878903,-0.021873428,0.022408715,0.0039835274,0.01302723,0.067121714,0.006940336,-0.018538069,0.046002638,0.03888399,-0.025156178,-0.07206457,-0.00894986,-0.062262498,0.015221132,0.041458976,0.07432855,0.01659236,-0.024314873,0.082643166,-0.07729299,0.024721878,-0.046547927,0.0060653985,0.042761013,-0.045291197,-0.029558474,0.058065668,-0.030493004,0.024230316,-0.062043864,-0.0027343032,-0.009302796,0.041535646,-0.05847705,0.022751495,-0.019592855,-0.024531504,0.107898325,0.006373773,0.07052848,0.0053827623,-0.005447728,0.035622258,-0.015853586,-0.012779523,0.01436603,-0.011980363,-0.09702572,-0.014002968,-0.0007984486,0.026781358,0.05375329,-0.019875212,0.019397408,-0.06370845,0.082495056,-0.036613632,-0.18096036,-0.101139255,0.026718978,0.030724471,0.098329514,0.04798986,0.029318528,-0.03717299,-0.00647918,-0.0009237303,0.085431404,-0.055264786,0.13020757,0.07761879,-0.018270388,-0.088047005,-0.028801372,-0.0004899866,0.019850435,0.07763307,0.026390363,-0.036122445,0.033957474,-0.05689538,1.0181176e-34,-0.0062472126,-0.01790574,-0.019806663,-0.050531507,0.005403492,0.009108957,-0.07469102,0.010323536,0.07735477,0.04950169,-0.042479683,-0.08035154,0.11064234,0.042580817,-0.023750583,-0.029998021,0.00591371,0.026874272,0.02494705,0.039040685,0.012625273,0.08245442,-0.08973556,0.036213867,-0.102601364,0.04104667,0.008349233,-0.04817566,0.10856963,-0.038104646,0.11381233,0.04141893,-0.077598594,-0.028663376,-0.0011742024,-0.057508722,-0.049831245,-0.021635776,-0.0012281169,-0.01855835,0.060177438,0.034334682,-0.036194626,-0.014111049,-0.005047186,-0.047820788,0.004586426,0.041182097,0.10014201,-0.018148808,0.038021777,0.04486902,0.10506724,-0.038653925,-0.076153345,-0.021870455,0.011499322,0.018656181,0.14185397,0.029321333,-0.078978986,0.0227655,-0.03735442,-0.0161802,-0.0054987697,-0.0019189802,-0.061302043,-0.043031987,-0.034426555,0.030282982,-0.012982829,-0.032906186,0.031226115,0.058187395,0.024740053,0.008280006,-0.008044255,-0.0020904623,0.008869291,-0.014291429,-0.046265688,0.0075117997,0.06646916,0.06954323,0.022124855,-0.06988375,-0.05581121,-0.08401714,-0.025516149,0.091378145,0.047920354,-0.060043246,-0.10223671,-0.07590433,-0.023101756,-2.0736523e-33,0.015306358,0.016594775,-0.06399477,-0.083278656,0.0046174354,0.0521332,0.0026872063,0.01908476,-0.018506905,-0.0019023246,0.13532144,-0.006585392,0.008640327,-0.0200546,0.035605963,-0.0017762722,-0.00011019058,0.031525142,-0.048783384,-0.031795155,0.078886546,0.044632573,0.075826064,-0.020634485,0.04211302,0.03157495,0.06189876,0.069706306,0.018286612,0.05219437,-0.010132228,-0.04151298,0.017755391,-0.0018295507,-0.034119677,0.05455859,-0.04030662,-0.033974644,-0.04588011,0.024311023,0.013513272,-0.05495151,0.043662306,0.08967155,0.028222831,-0.011698899,-0.14056395,0.03260518,-0.015143896,-0.002602762,0.0010207326,-0.0024310844,-0.013459077,-0.12717998,0.030408489,0.0039917263,-0.015532088,-0.07746954,0.025373332,-0.009215384,0.0018682004,0.084710844,-0.01636036,0.009924449,-0.020531287,-0.012037092,0.029586015,0.044710077,0.008726451,-0.062252834,0.029805172,0.020925216,0.0744648,0.017501835,0.052455235,-0.07195532,-0.03585121,-0.054921925,0.03999011,-0.10530611,-0.01567121,-0.009821285,0.040585715,-0.057187896,-0.01969724,-0.0541559,-0.056516334,0.035861827,-0.020464005,0.0101242615,0.014720534,-0.013131036,-0.05163488,0.09311061,0.0767723,-3.4139504e-08,0.027021438,-0.11487098,0.11281344,-0.0003684371,-0.02882003,0.05231053,-0.00725736,0.08127212,0.020002646,-0.032164045,0.01360249,0.0030218982,-0.057497136,-0.008050022,0.026837137,-0.03539992,0.033772573,0.039394666,-0.08002266,-0.123906404,-0.106098585,-0.04097713,-0.03475791,0.022299347,0.06890982,-0.05447122,-0.032793023,-0.048847176,-0.10246821,-0.04396263,0.04712579,0.031382293,0.030022947,0.015909364,-0.008914236,0.0014654422,-0.073219284,0.0169648,-0.04062611,-0.0090468535,-0.041669317,0.11648905,-0.06725435,0.034982268,0.032260735,-0.07829769,-0.0357248,-0.024559898,0.013709663,-0.077506736,0.017583543,0.007641248,0.0061299494,-0.067232214,-0.070230536,-0.030830482,-0.0676653,-0.04715084,-0.034301903,-0.039307684,0.04491325,0.060074463,0.13900642,0.015060058 +4.2.1.91,"Also acts on prephenate and D-prephenyllactate. cf. EC 4.2.1.51, prephenate dehydratase.",384,1.0,-0.07786147,-0.06998583,0.009469472,-0.047238883,-0.008765191,-0.029228594,0.03527013,-0.0032499274,0.0020408032,0.011531967,0.05291125,-0.010370868,-0.09946937,0.022247124,-0.032630764,0.045928843,-0.084539644,-0.014264994,-0.006477874,0.010621857,0.09128269,0.035256773,-0.045529578,0.010731774,0.1279493,0.005033433,0.054095306,0.02607863,-0.026094029,-0.024140757,-0.033444643,0.058780823,0.02039483,-0.066663206,0.06399327,0.072612636,-0.06066986,-0.019753268,0.0166933,-0.012346275,0.093133226,-0.054500572,-0.016485853,-0.010560153,-0.033440247,0.04376587,-0.024569932,0.07134277,-0.005534777,-0.0074208975,-0.046992928,-0.08168963,0.012226545,0.035769254,-0.005401539,0.04454712,-0.077751786,0.059137773,-0.031698268,-0.016869707,-0.026906963,-0.040983453,-0.03292246,0.0573371,0.039120294,0.03443379,0.06371569,-0.052992783,0.0012903679,-0.067029096,0.010823735,-0.026695834,0.06338202,0.04123367,-0.0061533125,0.016881749,-0.0235577,-0.042863876,0.0048390436,-0.080320396,-0.00963704,0.089065924,0.08968672,0.01421244,0.10920186,0.029339934,-0.024702532,-0.091573805,0.0018523904,0.035558548,-0.0044186413,-0.009870756,-0.06917894,0.038280737,-0.16156343,0.045868885,0.030636026,0.09149531,0.050412104,-0.018857742,-0.01932514,0.024409834,-0.035342578,-0.0062038405,-0.03821428,-0.0032095453,0.052896485,0.0015027736,-0.031273756,0.003580096,0.026779495,-0.046872027,0.09749414,0.034658972,-0.09367025,0.060508784,0.014510378,-0.00038875826,0.023584904,-0.042672344,-0.016914297,-0.059633616,0.053537335,0.031301066,-0.061082922,0.055791266,-0.07510504,7.5288466e-34,0.045392618,-0.040487077,0.030660344,0.04388727,0.0075560394,-0.013553052,-0.1024459,-9.742173e-05,-0.03553885,-0.07333767,-0.041294415,-0.0881481,0.018933013,0.047466844,-0.060990043,-0.05033008,0.06687593,-0.0037487515,0.00044677663,-0.016864398,0.065862834,0.09166035,-0.07430155,-0.009916949,-0.042804953,0.03782446,-0.03878246,0.005686498,0.051160388,0.04482431,0.0039853705,-0.1071525,0.0035310383,0.015846737,-0.05028846,0.08017855,-0.090407416,-0.04076865,-0.046490192,0.06342005,0.028477106,0.00019092612,-0.018706372,-0.08204963,0.021689001,-0.027369991,-0.047348183,0.0853693,-0.0016436819,0.017262165,0.048579898,-0.016788183,0.06568393,-0.03987565,-0.07960372,0.0055499715,-0.0072608995,-0.065669075,0.0160851,0.10982794,-0.011655878,0.07472943,-0.06010319,-0.011152733,-0.014107213,-0.020356895,-0.0847623,-0.044573568,-0.038598128,-0.042486135,-0.0939766,-0.03752562,0.09334244,0.07367747,0.053334832,-0.016293341,0.0030125654,-0.018317454,-0.0065310313,-0.013487988,-0.037141446,-0.060285915,0.0078068315,-0.014195356,-0.044115823,0.0077118184,-0.00882318,-0.04930181,0.0017531809,0.014739432,0.03154069,-0.042592164,-0.06258231,-0.017801497,-0.0042232447,-2.2344204e-33,0.041530725,-0.06700632,0.0036193915,-0.0208144,-0.0312285,0.089134805,0.05147069,-0.0035116589,0.07078319,-0.06288156,0.08573195,-0.051043566,-0.07552368,-0.090609655,-0.0007555165,0.076552,0.0218732,0.03400553,-0.039989144,0.004004797,-0.00057539454,0.10766845,0.030936155,0.06544001,0.025096972,-0.007822283,-0.006897549,0.015801398,0.019877983,0.09470066,-0.068094045,0.02070225,-0.020128382,-0.03962903,-0.082240805,-0.007961011,-0.06773181,-0.0770116,-0.026039122,0.0043713353,0.0244455,-0.05863653,0.060639698,0.09093137,0.03454541,0.053674337,-0.059533328,-0.016741747,-0.08164665,-0.014646175,0.054374088,-0.00069727167,0.021874519,0.05946452,0.025897799,0.045475516,0.08798573,-0.02507938,-0.056958385,0.003596098,-0.0023547222,0.01461017,0.07562272,-0.049778774,0.09484196,0.017226791,-0.0749244,0.095518835,0.07792357,-0.03263003,0.020983305,-0.003390557,-0.09923069,0.04859181,-0.0749802,-0.080455534,-0.048390467,-0.0048005045,0.023434846,-0.008817244,-0.080642976,0.01686089,-0.024171254,0.053463817,0.03523653,-0.0038959996,-0.007606282,0.04633898,-0.02667007,0.070406795,-0.039285634,0.03508177,-0.039809138,0.118937835,0.057674654,-3.0986634e-08,0.00978524,-0.066825494,0.048061922,-0.014854319,0.03051608,-0.081593655,0.06991183,0.05899076,0.026435476,-0.1048456,-0.05033491,0.09578263,0.03709665,-0.055224888,0.027810583,0.0214027,0.0027170766,0.03496597,-0.110397816,-0.018159566,-0.03281327,-0.05252339,-0.11758807,0.049101397,0.03169056,-0.053408947,0.032345157,0.0927504,0.019069143,-0.049642447,0.023247559,0.012745982,0.017467692,-0.030310111,0.024647105,0.04946037,-0.0006021837,-0.05671654,-0.06639484,0.087996185,-0.0172407,-0.04357601,-0.004686637,0.027337179,0.027795939,0.0065210913,-0.009280936,0.04376086,0.029667595,-0.019018596,0.038634304,0.05107548,0.006014064,0.010574937,-0.11727073,0.040924937,0.029695373,-0.001421417,0.0537034,-0.032573,0.06682813,0.0261022,0.13750228,0.0027801087 +4.2.1.92,"Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides. The product of the above reaction is unstable and is acted upon by EC 5.3.99.6, allene-oxide cyclase, to form the cyclopentenone derivative (15Z)-12-oxophyto-10,15-dienoate (OPDA), which is the first cyclic and biologically active metabolite in the jasmonate biosynthesis pathway [3]. The enzyme from many plants belongs to the CYP-74 family of P-450 monooxygenases [4]. ",384,1.0,-0.08869048,0.013608625,-0.060372427,-0.008007753,0.094084986,0.017341983,-0.08109256,0.07122541,0.007949976,0.00817796,0.01729267,0.020960964,-0.03383346,-0.033869687,-0.04464922,0.14336161,-0.01503893,-0.01809952,-0.022115717,-0.038722616,0.049928293,0.041977916,0.014987726,-0.031201884,0.023670811,0.017107949,0.019864803,0.026938852,-0.07436646,-0.015203663,-0.003899221,-0.015057494,0.064035326,-0.10896623,0.0030911888,0.03562327,-0.039698295,-0.07204448,-0.02346695,0.016056089,0.039219238,-0.04616433,-0.06327801,-0.02707762,-0.0038632224,-0.04754113,-0.004837448,-0.036619626,0.048289254,-0.046138648,-0.047514323,-0.096973486,-0.042808294,0.009564066,0.050325096,-0.030646404,-0.042001694,-0.012210884,-0.05673874,0.0057657002,0.013347552,0.021476457,-0.050097976,0.044296898,-0.041071597,-0.02691812,0.0025103823,-0.05691464,-0.07195053,-0.09714884,-0.027524145,-0.08173022,-0.020788768,-0.039446466,-0.12996225,0.09370242,-0.014426811,-0.03543242,-0.014745972,-0.015293837,0.03192977,0.014790286,0.029103179,0.011362027,0.01721048,0.02728412,-0.0074035963,0.022160212,0.021382123,0.11141726,-0.016239764,0.022381673,0.009951098,0.052785125,-0.013903269,0.06255361,0.08066082,0.0049606124,-0.028722534,0.0039469013,0.035190307,0.081715174,-0.04411456,-0.05191631,-0.07626241,-0.0015238298,-0.004227494,0.02023175,0.008965021,0.027144816,0.029941387,-0.10280145,0.009470455,-0.027250845,0.023124926,0.048720002,0.012604834,-0.01647371,-0.038133588,-0.01752263,0.015690563,-0.044099744,0.028027046,0.03282067,-0.0067931153,0.0625625,-0.087113775,1.2462819e-33,0.11800676,-0.019754244,-0.021871708,0.04675628,-0.01592541,-0.038971696,-0.078501366,0.022134598,-0.05655956,-0.0476472,-0.0853138,-0.06938358,0.04479575,-0.09753497,-0.068155326,0.0055858875,-0.040664237,0.03140765,0.055693377,0.04149541,-0.021994973,0.009457754,-0.07496463,0.02995066,-0.03942464,0.0754645,-0.011379063,-0.06190471,0.015105874,-5.8588184e-06,-0.0526491,-0.06920201,-0.08393972,-0.026232079,0.04948138,0.03383355,-0.026064977,-0.03839698,-0.0867771,-0.003825011,-0.0004594975,-0.0060782833,-0.00076821796,-0.017777802,0.08596214,0.016516214,-0.069469064,0.052828524,0.08887219,0.060084004,-0.021408232,0.014932083,0.05366381,0.04287445,-0.05660079,0.059084468,-0.033862576,0.06636678,0.05089961,0.054267142,0.025092147,0.07823771,-0.03290653,0.040469024,-0.004764054,0.08870425,-0.08602591,-0.08349811,-0.036739785,0.11370085,0.028056594,-0.031036545,0.07389034,0.018695869,0.06454597,-0.015886258,0.046966717,0.024176674,-0.012271661,0.0058229268,0.123307064,-0.028116189,0.0024326607,-0.012952102,-0.014072901,0.024589196,-0.062396806,0.038423505,0.023317479,0.07676757,0.071271226,-0.07621612,0.033319548,0.028202789,-0.068715915,-2.2918448e-33,0.06926026,-0.06247114,0.02237501,-0.09088176,-0.009702638,0.05248354,-0.036212716,-0.052055355,-0.005074431,-0.016636526,0.07561913,0.008213061,0.06581471,0.009805645,-0.013529357,-0.05373059,0.04169603,0.09658696,-0.034676153,0.03701799,0.023112826,0.048188217,0.018491164,0.055599067,0.055629816,0.01639045,-0.008549702,-0.0035375422,0.018835003,0.03421657,-0.04955433,0.032917332,-0.038828034,-0.022137793,-0.04022243,0.06445806,-0.08154391,-0.018160075,0.037265748,0.08419861,-0.07135748,-0.013483908,0.023137396,0.004791475,0.031402722,-0.031648893,-0.12748799,0.018982928,0.05642513,-0.04417046,0.014983098,0.054836635,-0.066045366,0.034910116,0.04836664,0.07148464,0.052925054,0.08810286,0.034667082,-0.07135345,-0.02144719,-0.0459303,0.04907238,0.050651196,0.033693895,0.13157235,0.056870796,0.05023715,-0.053176794,0.027750151,0.005916905,-0.006574274,0.053593993,0.024436368,-0.0054582646,-0.024359563,0.028677132,-0.0049971133,-0.057946406,0.045693938,0.014370585,-0.014018179,0.04592023,-0.04691692,-0.12955111,-0.11083685,0.033325005,0.052247044,0.047948975,0.02199405,0.021419007,0.025450353,-0.056436136,0.061627597,0.017384179,-4.1290416e-08,-0.029852094,-0.0881659,0.07798648,0.018885778,0.0009813567,-0.021319594,0.045823477,-0.03638742,0.106042616,-0.048024062,0.07905517,0.09130953,0.023363566,0.010989982,0.06754034,-0.009669664,-0.036042843,0.029026907,0.0041401065,0.03585333,-0.078514755,-0.015471549,0.0043337853,-0.03182259,0.0124060735,-0.12492544,-0.022552121,0.051195476,0.0685557,-0.037622314,-0.027995916,0.04234341,0.011845976,-0.04897898,-0.120538935,-0.008246654,0.009472836,0.0004373586,-0.0761888,0.024584875,-0.090537734,-0.105191655,-0.012491231,0.02244761,0.007755372,0.020228699,0.028006025,0.020019399,-0.030911116,-0.01720914,0.004603,0.026186142,0.029947571,-0.06084866,-0.05138837,0.0061850897,0.04085976,-0.061799515,-0.03376398,-0.05240234,-0.07326164,-0.0022858132,0.19168918,-0.018456329 +4.2.1.93,"Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers, and these are interconverted by EC 5.1.99.6, NAD(P)H-hydrate epimerase, to a 60:40 ratio [4]. Hence EC 4.2.1.93 together with EC 5.1.99.6 can restore the mixture of hydrates into NAD(P)H [3,4]. The enzyme from eukaryotes has no activity with ADP, contrary to the enzyme from bacteria (cf. EC 4.2.1.136, ADP-dependent NAD(P)H-hydrate dehydratase) [4].",384,0.99999994,-0.053542275,-0.018599609,0.0032338689,-0.03017972,0.08363273,0.08586798,-0.009580911,-0.0049849898,0.010820149,-0.0042380663,-0.013794537,5.7250454e-05,-0.08601077,0.072120905,-0.024723075,-0.024054782,-0.0399934,0.00013088831,0.003295332,0.040006462,0.0740736,-0.025172327,0.027370421,-0.026661959,0.0579081,0.055891503,0.0967528,0.012190577,-0.008196242,-0.08830223,-0.077861704,-0.05080293,0.001724456,-0.0988662,-0.00075360225,0.14348707,-0.027346374,-0.021828497,-0.03063319,-0.0044146655,0.05898933,-0.0043537966,-0.06413668,-0.00081837503,-0.0069071925,-0.029483093,0.006653757,0.09683632,0.019347504,0.010097914,-0.0088946875,-0.0065399576,0.004287892,-0.023455758,-0.032940716,0.050087042,-0.00085864175,0.0014829064,-0.0527923,-0.15557352,0.027290674,-0.03529665,-0.0069308733,0.05711538,0.06850614,-0.030010357,0.11488562,0.0010574324,-0.019646393,-0.033844877,-0.1533789,0.010986512,0.027611118,0.041588046,-0.026639752,0.024111765,-0.058416337,-0.04754555,0.033068877,0.009416289,0.023089398,-0.02150766,-0.024699582,0.07146924,0.031687222,-0.048717704,0.01905051,-0.005223976,0.03690326,-0.06178524,0.016090194,0.011174986,-0.047776584,0.009360143,-0.15814304,0.02854901,0.042424697,0.07715569,0.051951375,-0.061161287,0.012773677,0.14183676,-0.039005216,-0.063665874,0.093216315,0.044880833,-0.017871292,0.15371466,0.019960795,0.059134185,-0.07826862,-0.055107053,0.055095054,0.0058580847,-0.019071873,0.033291813,-0.07340188,-0.03844269,-0.09676921,-0.006257586,-0.015302051,-0.0010499544,0.10581255,0.03402306,0.029966295,0.03720993,-0.11949386,7.723299e-34,0.0761068,-0.050828524,0.01720827,-0.009665269,0.030523842,0.028454786,-0.073127896,0.027327513,-0.046693854,-0.033897243,-0.05394885,-0.064251795,0.07066987,-0.018301057,0.014114647,0.05725064,-0.0068367384,-0.009793792,-0.019811062,0.020144904,0.06438795,0.087042555,-0.028416768,0.005873749,-0.02980548,0.0013675796,0.018467262,0.07703339,0.05086503,-0.013048825,-0.001069325,-0.119602405,-0.050812922,0.025605923,0.08784958,0.021134948,-0.04004057,-0.026718128,0.010376806,0.030709174,-0.014954461,0.035193216,0.049631063,-0.10514904,0.04542704,-0.113237925,0.013506357,0.060839187,0.03432271,-0.01154759,0.014712479,-0.035814863,0.0831103,0.0002572183,-0.07091869,-0.018740574,-0.029019466,0.019555971,-0.03155638,0.10391107,0.011259349,0.060078446,-0.03700475,0.050560232,-0.06682495,0.04663286,-0.059085,-0.030821057,0.01615752,0.057453547,-0.047067028,0.04306003,0.060869183,0.06488571,0.0013651006,-0.03910997,0.041305136,-0.03321603,0.010014678,0.012780388,-0.04574391,-0.05090228,0.029588632,0.06153139,-0.028738096,-0.0007727255,0.00022811469,-0.040373653,0.061679937,0.053056765,0.08783795,-0.040045258,-0.061153617,-0.07675727,0.015704315,-3.0487078e-33,0.15118706,0.0063669966,0.05981767,-0.06798694,-0.015850637,0.12851834,0.024753783,-0.002358263,0.028297871,-0.09475093,0.053072773,0.031540964,-0.0007498515,-0.06996957,0.025343554,0.039549798,-0.012608182,0.07944175,0.0037399267,-0.009592287,0.0214301,0.05459668,0.007072097,-0.002370476,0.061170798,-0.059533108,0.041247085,0.02300048,0.018304067,0.046271212,-0.008191894,-0.004721029,-0.08515363,0.016891195,-0.0060379817,-0.010102104,-0.084082924,-0.04131204,-0.022192448,0.057362214,0.039643265,-0.03852314,-0.038484305,-0.059748262,0.07220976,0.0348431,-0.07282219,-0.052929033,-0.027992725,-0.036984686,0.08122581,-0.060329035,-0.029166315,0.032726485,0.017118787,0.002870041,0.03367704,0.0026437552,0.006890364,0.051020563,0.020550769,-0.0002578559,0.0033699158,-0.019239798,-0.029169273,-0.019086897,-0.018271368,0.06140332,-0.004382358,-0.013662167,0.04433213,-0.02887317,0.012486551,0.04253239,0.06098706,0.009893722,-0.084247075,-0.0081592705,0.0059869112,-0.056314223,-0.028644543,0.07596028,-0.030757237,-0.063824534,-0.016346972,0.0015577354,0.029124333,-0.006135178,-0.03454468,0.04222636,0.0040597213,-0.04974754,-0.025073975,0.0770094,0.0433969,-4.4649884e-08,0.02530364,0.034136377,0.040662296,-0.010216316,-0.03743771,0.024271281,0.027942544,-0.010074444,0.038968842,-0.01381988,0.0078053838,0.06962415,0.028499382,-0.0021494622,-0.0046353014,-0.03636071,-0.0418142,-0.0020583076,-0.08627584,-0.048686743,-0.08643184,-0.031233918,-0.099257775,0.05882679,0.05827715,-0.023825778,0.007163276,0.0038502128,0.009945175,-0.11990729,-0.030851092,-0.025018038,0.0005992878,-0.023707908,0.024406372,0.066962644,-0.031936005,-0.024314415,-0.088299796,0.08712987,0.040487602,-0.09684279,-0.04442673,-0.00074926903,0.0903611,0.021761857,0.0004477416,0.010691835,-0.05608599,-0.050548293,0.029620735,0.021290122,-0.032452017,-0.104364075,-0.046598643,0.048831858,-0.034492403,-0.0955314,-0.02335913,-0.037496805,0.09196761,-0.011274519,0.08267233,-0.066349775 +4.2.1.94,"Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.",384,0.99999994,-0.041100454,-0.042261984,-0.10457805,0.0029701376,0.06792317,0.03738234,0.01760301,0.03989058,0.006569112,-0.012353008,0.05935046,-0.13269502,-0.0702729,-0.008756008,-0.12780486,-0.024327597,-0.07042641,0.051303763,-0.050798584,-0.012082281,-0.011856513,0.022971077,0.04392531,0.020186998,0.016280444,-0.07848934,0.022136396,-0.050436635,-0.057039935,-0.080703355,0.016008891,-0.050638698,0.030464413,-0.01791172,0.031015584,0.056343935,-0.03144203,-0.064737715,-0.023681778,0.019082151,0.011877812,-0.02763153,0.043854788,-0.08255706,-0.015071658,-0.007286734,-0.04821127,0.05031837,0.032709986,-0.027513938,-0.02257926,-0.0117006125,0.006534373,-0.008337784,0.034011062,0.049564566,0.03875615,-0.0018231014,-0.002216,0.07200508,0.05911038,-0.0798729,0.037264608,-0.074563555,-0.02606432,-0.055623997,0.043022204,-0.11709069,-0.04482762,-0.036324527,-0.06300283,-0.037445486,0.0048095305,-0.026401382,-0.026078139,0.14481999,0.04731981,-0.050790414,-0.04047381,-0.0021501444,0.04481099,0.04428907,0.003782861,-0.016948186,0.018234424,-0.047988042,-0.018064043,0.03113938,0.010093206,0.1359552,0.05017317,0.09831382,0.065947376,0.029176502,-0.11213245,0.08299433,0.078515515,0.097204626,0.06756586,-0.030782226,-0.049244266,-0.005114718,-0.032207947,-0.020489812,-0.11915085,-0.08854691,0.0002205729,0.024419589,0.018933758,-0.034520783,0.09243634,0.00442914,0.0035233826,-0.02330594,-0.024772106,0.038343716,0.0019973686,-0.05955631,-0.009957906,0.05223928,-0.016336756,0.00070677255,0.011301682,0.002703051,-0.0055378755,-0.034598667,-0.04446556,2.0650255e-33,0.09980464,0.08984069,-0.026260942,0.019981217,0.07440575,0.024310725,-0.11262744,0.031423166,0.019042568,-0.1570381,-0.025298405,-0.005482027,0.0017166921,-0.082454294,-0.0422691,-0.00010210901,-0.0115515245,-0.064537086,-0.013361023,0.017227858,0.047203254,0.0075447196,-0.08149506,-0.014025632,-0.041344896,-0.008021799,-0.037795667,0.016108396,0.022576578,-0.007630297,-0.033768002,-0.0880382,-0.030345317,0.07958965,0.10914284,-0.05318735,0.024721613,-0.025287505,-0.0055393935,0.0033358186,-0.013921295,0.059561107,-0.0046911375,-0.011719302,0.03217788,-0.0024708959,-0.031501148,0.079023965,0.07346357,0.06903648,0.010699708,0.0073782494,0.12299611,-0.029082892,-0.010677994,-0.0136028025,-0.056390207,-0.029381568,0.003329193,0.03755997,-0.0017342521,0.09747592,-0.012888734,0.00029859776,-0.0031784775,-0.033041507,-0.041632686,-0.020938884,0.029848551,-0.083333425,0.0075628753,-0.034565374,0.06497313,0.0045863767,0.012879259,-0.011958002,-0.024056058,0.024036685,-0.044855807,-0.005999689,-0.048042227,0.07990924,-0.015392571,-0.030237315,-0.03884506,0.06742465,-0.028042316,0.04660484,0.07047616,0.0025778813,0.04017957,-0.0937984,-0.037944835,-0.012999712,-0.031811427,-2.798313e-33,0.101585634,-0.05810331,-0.021764265,-0.03802763,0.008694232,0.06126137,-0.0078116683,0.06953848,-0.01566588,-0.045024626,0.075524464,-0.012297346,0.07170822,-0.012051072,0.022500869,-0.05713525,0.05362197,0.13897339,-0.040801518,0.0121603655,-0.04143039,0.009019958,-0.06408668,0.052882798,0.012255449,0.05654977,-0.020159507,0.091709584,-0.07052721,0.038185168,-0.05625095,0.019471109,-0.030637555,0.0072146924,0.02859249,0.0026778518,-0.059438195,-0.05121156,0.06600851,0.06388731,-0.0017037767,-0.029317014,-0.027166108,0.027562892,0.05394021,0.060101897,-0.07221864,0.04008447,-0.030390045,-0.020496352,0.031555623,0.024130674,0.014176589,-0.020710457,-0.030731553,-0.032706093,0.049513504,0.06930832,0.0512813,0.056920957,-0.017726213,-0.04419186,0.036021262,0.034210064,-0.04115817,0.02441571,0.0045070266,0.080346644,0.12383805,-0.0673707,0.1037518,0.06281085,0.05516392,0.068077125,-0.06161874,-0.06519475,0.019303927,-0.011199495,0.02470209,-0.014935302,0.06136527,0.0039944295,0.088034675,-0.07093852,0.04041018,-0.0075634713,0.08430432,0.013969515,-0.11462626,-0.028226437,-0.034919187,-0.0077158217,-0.07323919,0.1208733,0.050696846,-3.060973e-08,0.050336834,-0.010818333,0.03345899,-0.08745451,0.06686344,-0.00080101046,0.04785949,-0.012380994,0.045125414,-0.022460544,-0.025210459,0.04848639,0.039954837,0.044792578,0.032574542,0.029432487,-0.004354793,-0.014543856,-0.0190596,0.051140577,-0.045938924,-0.016887598,-0.13074625,-0.010892259,-0.051693417,-0.00222438,-0.015120814,0.022628758,0.028084068,-0.048994094,0.03833739,-0.0006354494,0.008056409,0.0020994185,-0.05187464,0.027802559,-0.053528402,-0.044593308,-0.020401556,-0.012015805,-0.026909515,-0.0090793,-0.020779997,0.02370306,-0.068869375,-0.065230414,-0.06576686,0.05559693,-0.008866529,-0.00036184693,0.038961023,-0.007825571,-0.029216439,-0.029064521,-0.093500994,-0.11283129,0.089527786,0.03562126,-0.09564583,0.02777466,0.0072524087,0.0034980087,0.1031791,-0.009827953 +4.2.1.95,"The enzyme from Fusarium sp. hydrates the methylbutenyl sidechain of the isoflavonoid phytoalexins, thus reducing their toxicity.",384,1.0,0.03206415,-0.01197563,-0.06415891,0.07254486,0.10345623,0.030414412,-0.08149652,0.057698287,0.075582445,-0.10118515,0.064720474,-0.042058006,-0.010985962,0.01186625,-0.105663456,0.016018532,-0.045205515,0.060808007,-0.039523292,-0.032778483,-3.779206e-05,-0.029205237,0.019018117,-0.010852436,-0.076864064,-0.025989143,0.009445725,0.0335639,0.0006539285,-0.05459859,0.034993995,-0.00048682684,-0.008541139,-0.011170333,-0.086576335,0.10724798,-0.05255778,-0.049265686,0.08593545,-0.05301934,-0.0023275292,-0.007822091,-0.008289801,-0.033274107,-0.034783404,-0.067874245,-0.036353346,-0.006580371,0.05514634,0.034821156,-0.00593375,-0.040164486,-0.016699666,0.038011868,0.022269348,0.009097623,0.03975355,0.0011669829,-0.058682796,0.025066681,0.014567096,0.0021370878,-0.04462733,-0.035744395,-0.015947,-0.025594002,-0.043576654,0.02903948,-0.005341446,-0.014042221,-0.026920712,-0.0037298282,-0.017274905,-0.01237895,0.01625099,0.10291246,-0.016249267,0.019850424,-0.0108331395,-0.015483469,0.071778804,0.06681866,0.11114585,0.07498353,0.043992132,-0.04830436,-0.055341996,0.040176123,0.03065165,0.03929485,0.084910974,0.10281848,0.065783955,0.010218392,-0.017019043,0.072857134,0.018634016,0.062064018,-0.06283858,-0.0051312097,-0.022668092,-0.020785121,-0.10643139,-0.064785585,0.07142948,0.021213869,-0.04312094,0.0141327055,0.062471382,-0.06338666,-0.054100093,-0.010632943,0.010836634,-0.05779455,-0.014911633,0.007831356,0.015818097,0.011900322,-0.07523054,-0.039876215,-0.020393182,0.018896407,0.04431686,-0.036110964,0.02531182,-0.07385332,-0.113257565,1.6663295e-33,0.041671056,0.005023316,-0.021362947,0.0038277071,0.057584383,-0.07943596,0.0071937907,-0.0093420055,0.024609135,-0.043184474,-0.11052774,-0.069720216,-0.07007613,-0.015526398,0.0035585961,0.0094327135,-0.06432177,-0.061788656,-0.008458857,-0.025795588,0.013108746,-0.08521083,-0.015141915,-0.052482534,-0.0009807303,-0.0045371917,0.005350122,0.042565823,0.02164719,-0.010213737,-0.040123343,-0.09628787,-0.088041596,0.014955015,0.047590595,0.039944753,-0.08154792,-0.034223475,-0.104057476,0.030719148,-0.005065118,0.07055222,-0.02199951,-0.062387206,0.055388562,0.034936838,-0.035973217,0.13973366,0.078805834,0.017407835,0.054291375,-0.0029471507,0.06491999,0.04605072,-0.055178985,-0.0066142483,0.04318052,-0.03113349,-0.05329223,0.0848743,-0.036402732,-0.03129157,-0.003412637,0.078746155,-0.054736696,0.02810939,-0.05094772,-0.04318574,0.05749357,0.015124671,-0.04176594,-0.04249289,0.0045230486,0.006641149,-0.029188784,-0.056887034,-0.04604058,-0.099585816,0.008221226,0.016313406,0.017984137,-0.027364653,0.057908256,0.022599839,-0.059179276,0.015031728,-0.08373059,-0.022501074,0.06629096,-0.04735504,-0.0004913789,-0.047465593,-0.012168589,0.011143781,-0.0042445655,-2.4340609e-33,0.008543245,-0.038733136,0.0050574797,-0.017555417,-0.03315474,0.063954,-0.045975227,0.05161437,0.036445603,0.04224049,0.010564095,0.03228652,-0.034581922,0.013280542,-0.0015024574,0.08890852,0.043653935,0.06519521,-0.0019731775,-0.03401907,-0.07920508,0.069212444,0.0055553326,0.04456074,0.054557193,0.060005575,0.03126494,-0.024431998,0.07460358,0.0850293,-0.013353442,0.04448053,-0.009173093,0.016497444,0.05743336,0.023451768,0.0057154703,-0.08507715,0.0065260027,0.09384447,0.019248324,0.020919453,0.004670463,0.02780607,0.038690556,0.07561422,-0.10720325,0.01548067,-0.035235174,-0.040305022,0.0693945,0.019974858,0.015226102,0.089424275,0.00559817,-0.029109031,0.07293639,-0.0015883527,0.02722918,-0.016535152,-0.060747966,-0.028949624,-0.03215347,-0.025552528,-0.029996991,0.054927725,0.011971156,0.0952197,-0.0022838821,-0.025482515,0.09285708,-0.020280154,0.0011793455,0.061662327,-0.05231868,0.016608313,-0.04173933,0.029778529,-0.020556808,0.10368932,0.0629222,-0.0016333099,0.024076955,-0.08800176,-0.025660394,-0.109018266,0.011773398,0.08671422,-0.0498927,0.021726394,0.027473528,-0.050447807,-0.044967927,0.053124808,0.044332076,-2.9146754e-08,0.0035730938,-0.047079094,-0.029084228,-0.03703851,-0.03718014,-0.0072969915,0.009565759,0.07366682,-0.026862929,0.046698872,-0.047474053,0.053474233,-0.060367912,0.070066996,-0.042354006,0.01987643,0.0028449846,0.054267656,-0.0126068005,0.030837923,-0.121766135,0.045255844,-0.09447599,-0.011973716,0.040288005,-0.06137079,-0.0027635503,0.038916163,0.035663832,0.060782366,0.026608702,0.007905142,-0.033382714,-0.05182004,-0.12030205,0.13788205,-0.019954417,-0.0698256,-0.008227837,0.11246712,-0.029899482,0.0015029564,-0.024390059,-0.01718787,0.030044084,-0.02170653,-0.018536262,0.089131445,-0.0035017387,-0.037434224,0.05088332,-0.012653869,0.030465469,-0.033696823,-0.09660502,0.003416274,0.0367223,0.00031755187,-0.006611976,-0.14093575,-0.018222375,0.04494048,0.22561844,-0.008248691 +4.2.1.96,"In concert with EC 1.5.1.34, 6,7-dihydropteridine reductase, the enzyme recycles 4a-hydroxytetrahydrobiopterin back to tetrahydrobiopterin, a cosubstrate for several enzymes, including aromatic amino acid hydroxylases. The enzyme is bifunctional, and also acts as a dimerization cofactor of hepatocyte nuclear factor-1alpha (HNF-1).",384,0.99999994,-0.0147327,-0.10969892,-0.11875443,-0.06121436,0.064050265,0.038398664,-0.043350626,0.04218355,-0.0032591324,-0.046750758,0.021442752,-0.03902825,-0.09793668,0.053950526,-0.08362751,0.013249032,-0.109331466,-0.0246789,0.060997915,-0.1121788,-0.0625185,-0.023487354,-0.039624877,-0.016855836,0.053343706,-0.008801893,0.04646892,-0.05569223,-0.06485228,-0.013619717,0.059199978,-0.025372518,-0.029203998,-0.028813984,-0.0018517863,0.14734866,-0.03580163,-0.023919687,0.02628439,0.051743332,0.034155287,-0.018238215,-0.036134344,-0.0079627745,-0.0143286185,-0.025400242,0.018958451,0.083228774,0.03422262,0.053821675,0.055814356,-0.009281378,0.0004610708,0.044730462,0.077098414,0.041329607,0.009828442,0.023804724,0.058700547,0.064139105,0.08044294,-0.021999806,0.056425236,-0.0310605,0.098165214,-0.06534897,0.0094816275,-0.06526179,-0.013505281,-0.09168731,-0.076747246,0.011887857,0.006540796,0.04576501,-0.043222435,-0.012381574,-0.07398257,-0.012311769,0.0003794191,0.044453587,0.039265256,0.02756943,0.03050664,0.09203634,0.04679247,-0.09626502,-0.029407097,-0.05243816,0.019374019,-0.022475839,0.054651674,-0.019663699,0.013781061,-0.0045439755,-0.09363095,0.04372313,-0.03653334,0.031456914,0.0066688303,-0.031698324,-0.059347037,0.05789381,-0.030292656,-0.04706461,-0.13580802,-0.020731812,0.0343352,0.13975702,0.071284026,0.025862988,-0.008062526,0.0002871825,0.035504784,0.02758599,0.01354866,0.0845469,-0.03691647,-0.05890276,-0.027555075,-0.004211279,-0.034782168,0.056081522,0.08988354,0.049790584,-0.0054736477,0.015829096,-0.08819385,6.874291e-33,0.045214787,0.06521481,0.023189304,0.008045082,0.004979617,-0.03557428,-0.054257788,0.024748322,0.035156615,-0.053227294,0.002361401,-0.027474228,0.052162874,-0.02855241,-0.08226754,-0.0829915,-0.026175082,-0.020594822,0.018179081,0.020235691,0.00025984115,0.06819644,-0.0404079,0.03455142,0.08119551,-0.018931443,-0.04733523,0.013162599,0.12057255,0.004815388,-0.07768957,-0.038857553,-0.10126202,0.016790383,0.033263095,-0.08805121,-0.060663566,-0.012439483,-0.021959778,0.04198972,0.04406894,-0.00056561857,-3.0305911e-05,-0.09574319,0.082208954,-0.087127104,0.02530059,0.0747186,-0.030321898,0.025922924,0.02793353,-0.0056999023,0.07258068,-0.0644429,-0.048221983,-0.04041153,-0.03229006,0.012163372,0.07717845,0.044039275,0.026236385,0.04891641,-0.052892312,0.02431996,-0.0153118335,-0.06538493,-0.0270716,-0.026313825,-0.017071404,0.058384195,-0.07985997,0.034827027,0.06564326,-0.0344767,0.02049687,-0.091297954,-0.06051948,-0.017614292,0.019851116,-0.051011946,-0.02509809,0.0119173415,0.04970197,-0.04434991,-0.01080003,0.003845788,-0.009712936,-0.08044694,-0.033741333,0.0003548897,0.012674479,-0.06606212,-0.040365692,-0.048762016,0.10944082,-6.1354817e-33,0.07706221,-0.09724604,0.026588442,-0.059673034,0.04385745,0.084493764,0.079725474,0.031227658,0.05345539,-0.051960763,0.05206099,-0.022072565,-0.045111716,-0.06467237,0.0849717,0.03451071,-0.02439104,0.09894351,0.0015005848,-0.024712171,0.04701558,-0.005105569,0.0138230035,0.004792533,0.027264865,0.041937217,0.010592615,0.049951192,0.13452455,0.023225717,-0.07577106,-0.0058023385,-0.057768036,0.019455789,-0.023512892,0.02795871,-0.11626376,-0.03177721,0.007445575,0.002910715,0.016032958,0.010928471,-0.025069531,0.05534299,0.008476634,0.052792132,-0.08860821,0.083113424,0.04598007,-0.045195453,0.027637348,-0.034109686,-0.056837138,0.04131015,0.013207541,0.067151174,0.10945121,0.023532132,-0.011286274,0.0062878975,-0.035443142,-0.058243882,0.032980774,0.0433641,0.009216204,0.0018950098,-0.022875614,0.08864112,0.053404454,0.05197154,0.02596731,-0.01583526,0.017528284,0.030517118,0.0075254664,-0.06574674,-0.028742308,0.03772913,0.031648036,-0.008983106,0.0129766045,-0.011411136,-0.0174388,-0.08956869,0.09647919,-0.054596867,0.018303582,0.07337299,-0.040915344,0.0580204,0.014675535,-0.037330877,-0.032402802,0.04741001,0.025866332,-4.417817e-08,0.062199347,-0.088031724,0.038827185,-0.034097806,0.09784727,0.0068557137,0.045104906,0.007202865,-0.032780908,-0.05494929,0.03995944,-0.008019188,0.03898754,3.763103e-05,0.056879837,0.001806153,-0.03950395,-0.020572528,-0.036675844,0.03299511,-0.01982872,-0.051567525,-0.10572981,0.056932364,-0.030214347,-0.0040666778,-0.0036029427,0.064670496,0.0037911178,-0.02635034,0.024296582,0.008314857,0.002318734,-0.055594616,-0.055889525,0.033501618,0.011213837,-0.014487232,-0.03204396,-0.022433478,-0.012120071,-0.017189572,-0.049093295,0.012547207,-0.0094884075,-0.023874313,-0.04670031,0.060812455,0.010066149,0.0582373,-0.05720841,-0.014193674,-0.0024830783,-0.03729326,-0.054598458,0.039710768,-0.009567399,-0.117861785,-0.031170785,-0.098851345,0.040553756,0.03160266,0.16077535,-0.0021898788 +4.2.1.97,"The enzyme from Fusarium solani, which is distinct from kievitone hydratase (EC 4.2.1.95), hydrates the methylbutenyl side-chain of the isoflavonoid phytoalexin, phaseollidin.",384,0.99999994,-0.022839397,-0.029085843,-0.0832403,0.059704803,0.11438367,0.031918023,-0.043370526,0.019215506,0.061223194,-0.121494785,0.06046456,-0.055333216,-0.055472143,0.03782828,-0.09150719,-0.024141967,-0.09830315,0.04790456,-0.030809892,-0.03209205,0.052384228,-0.038119245,0.041147348,-0.0033124317,-0.017103456,0.016084291,0.054711115,0.022913132,0.0047095343,-0.066790245,0.00080503296,-0.018415013,-0.025397303,-0.0008869129,-0.043227263,0.09759401,-0.027349386,-0.034349307,0.061604675,-0.06458443,0.010304432,-0.018597495,-0.021829912,-0.008434073,0.029409274,-0.02279134,-0.0304358,0.01598534,0.0577854,0.0102609275,-0.03508297,-0.0695123,0.0048554596,0.06553625,-0.0032282595,0.033528272,0.008325041,-0.0021492324,-0.006218497,0.06425708,-0.0016613351,-0.0039481525,-0.022991804,-0.04000823,-0.010332621,-0.008719738,0.009864584,0.04022583,0.007736843,-0.056794897,-0.014922532,0.0029887764,-0.009865855,-0.01100244,0.018843101,0.10699255,-0.001653374,0.024088746,-0.044346828,0.017353186,0.025668703,-0.018212056,0.048069287,0.090254456,0.019042302,-0.073295265,-0.08122917,0.047224917,0.04821461,-0.015089821,0.018942185,0.08768681,0.026702696,-0.056508698,0.013779857,0.09541398,0.06098424,0.0974117,0.012507232,-0.018237429,-0.017455038,-0.012763303,-0.07421122,-0.08766798,0.049621932,-0.014290209,-0.009146716,0.04217369,0.019837955,-0.06537675,-0.042157654,-0.017629545,0.034126,-0.015107159,0.003548031,-0.030651499,-0.0057339324,0.029718244,-0.073421404,-0.006295446,-0.01150426,0.03875642,0.07418973,-0.022311013,0.018715775,-0.039907843,-0.1322753,2.4866014e-33,0.0901962,0.0043206788,-0.013209402,-0.010468194,0.040947013,-0.034044296,-0.0037090292,-0.014163286,-0.034430146,-0.02238299,-0.12423024,-0.027675688,-0.060631737,-0.08259905,-0.013122342,0.009814561,-0.05116688,-0.021710277,0.016159661,0.0025509384,0.025347026,0.0029124995,-0.0462447,-0.064387,-0.021298165,-0.007973014,-0.014274512,-0.0045868773,0.062949136,0.0014008094,-0.036643863,-0.088096775,-0.10016979,0.042419985,0.07918452,0.012308842,-0.088597514,-0.0559406,-0.08869706,0.05510495,-0.005915307,0.052283037,0.006162832,-0.07271385,0.028458932,0.0347175,-0.032324757,0.15283523,0.12242442,0.03108731,0.0023802787,0.014351464,0.07250629,0.0022418736,-0.03876139,0.015200105,0.055628788,-0.008406061,-0.055427063,0.1252552,-0.011950573,-0.01951543,-0.050333217,0.04543813,-0.023037294,0.02734686,-0.06313448,0.0075546033,0.06597434,0.06338348,-0.048505627,-0.0323184,0.018254844,0.067943566,0.036063775,-0.07420525,-0.04156249,-0.038877696,-0.043813195,-0.033599887,-0.007969328,-0.027059518,0.069959,0.026988743,-0.073000826,0.037216127,-0.050767705,-0.009753192,0.013486736,-0.039964203,-0.02705925,-0.029827237,-0.019908557,0.008175145,-0.00860592,-1.9895782e-33,0.051373277,-0.06294178,0.041316256,-0.03186254,-0.012839371,0.1073777,0.005453321,0.00022022615,0.031383038,0.053318724,0.08751137,-0.03138559,0.0025431998,-0.013363747,-0.013717048,0.12480491,0.06489629,0.033173833,0.012459298,-0.056252718,-0.081317745,0.05438308,0.010626213,0.032030985,0.07389219,0.03225545,0.070085794,0.027787408,0.0051615625,0.13843662,-0.030178139,0.018439755,0.0019669943,-0.017417392,0.03767349,-0.003657955,-0.015880974,-0.11562687,0.015720963,0.09945398,0.0031926825,-0.0057648118,0.043687716,0.044296376,0.015167487,0.06618097,-0.06675844,0.038190246,-0.05387751,-0.054984823,0.051985182,0.0010406302,-0.008959654,0.063814834,0.012326769,-0.021178313,0.03903879,0.02026619,-0.021122068,-0.0363935,-0.011652993,-0.078271516,-0.031097708,-0.033434663,-0.006617848,0.016622959,0.034579057,0.052233752,0.008809747,-0.0025152299,0.08649588,-0.06304484,0.054669846,0.07803106,-0.0355563,0.0069753747,-0.015951706,0.029553195,-0.007933059,0.02001807,0.07813385,-7.8495665e-05,-0.012773671,-0.11666098,0.012530188,-0.10450978,0.01226925,0.12101654,-0.049008522,0.049076527,-0.00660149,-0.006145707,-0.095135555,0.09730173,0.06843412,-3.6657852e-08,0.057347994,-0.047973283,-0.022926068,-0.018872727,0.0036383527,0.029161625,-0.021902768,0.064037696,-0.060585447,0.044389453,-0.0051745535,0.068747416,-0.050690264,0.0043341573,-0.03226399,-0.019972578,0.020794325,0.10174764,-0.01156751,0.04193979,-0.05081876,0.021021891,-0.123414636,-0.062331747,0.0028348672,-0.0010138782,0.0013977048,-0.0022913765,0.03442584,-0.005550114,0.0008719288,-0.024717793,-0.026611418,-0.077416286,-0.13984986,0.12573174,-0.041950013,-0.029293936,-0.014550922,0.090454936,0.013783879,-0.006081338,-0.03813959,0.010909734,0.0019507452,-0.001726991,-0.026817743,0.07164032,0.0034555732,-0.027870877,0.04308236,-0.023052847,0.04993216,-0.032681234,-0.076141365,0.02411455,0.019132657,-0.022920523,-0.06822406,-0.07560691,-0.034709636,0.06996921,0.21494602,-0.013605306 +4.2.1.98,16alpha-Hydroxypregnenolone is also a substrate.,384,1.0,0.013511192,-0.010831838,-0.032772828,-0.10441277,0.0011246646,0.017521787,-0.03638559,0.06810938,-0.051945314,-0.07144293,0.0232023,0.015445594,0.058614567,0.1301997,-0.010323773,0.007046292,0.048223566,0.00851604,0.029086662,0.086079106,0.026963448,-0.047858898,-0.043910522,-0.024682658,0.014627772,0.063567415,0.073954426,0.04518751,-0.022143228,-0.008975092,0.004662563,0.08884565,0.0053448593,-0.08513656,-0.046415783,0.03613042,-0.09616807,-0.010716912,0.09712517,0.03074959,0.011612175,-0.014262482,0.036051176,-0.002321139,0.046512295,-0.004430999,0.023242757,0.01112681,0.06101096,-0.029717265,-0.036477756,-0.044938803,-0.009640571,0.055613518,-0.0059052096,0.0033993588,-0.096186236,-0.03488667,-0.06236678,0.062242832,-0.00050152506,0.0016043735,-0.05744255,0.034905683,0.026266366,0.01316512,-0.024569497,-0.010297274,-0.011022931,-0.0085146,0.022855451,-0.010442884,0.030075438,0.07388878,0.0051380536,0.038281478,0.026347594,-0.04109579,0.0733139,0.039903935,-0.051929176,-0.0067900615,-0.061700966,0.12271422,0.0657491,0.022042332,0.04398206,-0.04304,-0.09883831,0.127751,-0.051337067,0.008553254,-0.041717414,0.007315088,5.6485635e-05,-0.001025539,-0.05353939,0.019203946,-0.00067308976,-0.034224484,-0.017340742,0.04447723,-0.013031579,0.01505124,-0.09070367,-0.07122771,0.08382127,0.03397739,0.032586884,0.005095291,-0.01440661,0.06392741,-0.03647158,-0.056655325,-0.003029444,0.03598612,0.086657956,-0.0385721,-0.026961649,-0.04378061,0.010604817,0.023547638,0.031167002,-0.01399356,-0.044803746,-0.032761924,-0.029282639,-2.3714407e-33,-0.008041709,0.0052798977,0.054635305,-0.020825958,-0.032020826,0.00081495475,-0.028057337,-0.025903078,-0.034236304,-0.07376476,-0.09541308,0.016033353,-0.02575037,0.072812326,-0.013664732,-0.10108039,-0.01258613,0.002302022,0.07526046,-0.05262172,-0.016115313,0.075355634,0.010169585,-0.0033014428,-0.037377305,-0.03426075,-0.010250234,-0.0034673514,-0.0061990377,0.0125955185,-0.04153707,0.0074667837,-0.0967423,0.02991278,-0.003419112,-0.04322205,-0.07259527,-0.087700814,0.024013847,-0.018629903,0.04350482,0.01592989,0.023421567,-0.012938717,0.051033407,-0.06315479,-0.09234754,0.051323127,0.1038365,-0.017424738,0.09083536,-0.0009292082,0.009934195,-0.083258934,-0.08366419,0.028196933,-0.040138062,-0.031137107,-0.044577435,0.024621882,-0.022919407,0.11179944,-0.050489116,0.047792695,0.04667564,0.056052357,-0.012339284,-0.08631104,-0.018135842,-0.0055269026,0.039757363,-0.0106205745,0.072496295,0.022831243,0.03455289,-0.0009547344,-0.006845672,0.01951301,0.08615024,0.013922131,0.05478139,-0.04008176,0.0059454464,-0.0069477046,-0.10058205,0.05653604,0.09148003,-0.094931915,0.11209835,0.077441074,-0.0042638406,-0.07473835,-0.038294837,-0.010076658,-0.04571996,-1.2861944e-33,0.049396377,-0.1354209,0.055715382,-0.03756781,0.0026712061,0.021051416,0.057839733,-0.043721694,0.012220804,0.04748176,0.03410499,-0.045294277,-0.0117839575,-0.056620207,-0.03346436,0.008262776,-0.034111958,0.035500336,-0.01102169,-0.035632323,-0.013043893,0.107031465,0.032398283,0.14691949,0.03297272,-0.050800927,0.07461978,0.037781987,-0.01944532,0.09144543,0.0044927197,-0.015509484,0.027022798,-0.019080084,-0.027138485,0.085795045,-0.032134686,-0.030499222,-0.012798909,-0.11220641,-0.028531646,-0.035575382,0.067054436,0.024177495,-0.0070558507,0.009310432,-0.030858034,0.015245644,-0.026674388,0.053045113,0.0052905465,0.02009616,-0.033603244,-0.023964787,0.007281079,0.006405788,-0.07227063,-0.050478186,0.111371875,-0.08809865,0.0140839005,-0.065734215,-0.06137657,-0.11524954,0.08034322,0.042283896,-0.042164247,0.0077640293,-0.010093595,-0.00042239192,0.10950975,0.017187493,0.012561992,0.0017256177,-0.020658677,-0.022757005,-0.027381541,-0.03844947,-0.0396555,0.030330438,0.05097323,0.04017792,-0.063993715,-0.048216436,-0.006149778,-0.06785637,0.0072887708,0.044023536,-0.051086508,0.06580018,0.030497942,0.004050546,-0.11971809,-0.040070504,0.032759886,-2.2812783e-08,0.05541759,-0.015868217,0.051089793,0.004284497,-0.11520753,-0.028152103,0.04135697,-0.057023656,0.12342892,-0.05259531,0.048541874,0.08450381,0.029528666,-0.008623775,-0.015574389,-0.08819997,-0.08928126,0.031503174,-0.026086783,-0.016820993,-0.07104392,0.022423957,-0.056714922,-0.026189234,-0.007277349,-0.04900776,-0.0143243605,0.052408304,0.034382496,-0.077517316,0.083609246,-0.012136161,0.0485695,-0.059416123,-0.06616558,0.044467095,-0.010599411,-0.01782875,0.025852568,0.040294122,0.0028174247,-0.08776902,0.009487325,0.0477163,-0.0077944333,-0.018951314,-0.07659958,0.06438262,-0.022848489,0.0038680045,0.059475444,0.016089976,0.047652647,-0.06486896,-0.055941947,0.009327458,-0.042340733,-0.038060877,-0.025278786,-0.042522732,-0.0062103705,0.007067234,0.2024515,0.02889253 +4.2.1.99,The enzyme from the fungus Yarrowia lipolytica (Saccharomycopsis) does not act on isocitrate.,384,1.0,-0.0011976727,-0.11646244,-0.09370815,-0.036940433,-0.001427132,-0.032319594,-0.099961676,-0.062441304,0.048096422,-0.018581707,0.1469113,-0.044163167,-0.09478614,0.04006365,-0.0054668584,0.02101322,0.048004907,0.036946088,-0.036728006,-0.019170796,0.091350906,0.012284534,0.057160188,0.02692723,0.041405905,-0.026004838,-0.05884607,0.03803419,-0.022109253,-0.14099644,-0.044529106,-0.04699413,0.025310824,-0.058540184,0.046298273,0.07386829,0.018661367,-0.024538476,0.062081218,0.038641255,0.016373277,-0.09509945,-0.07927761,0.000398493,-0.05742153,-0.0391366,-0.079824775,0.0045234626,-0.022683194,-0.01788564,-0.06560808,-0.108576074,-0.047828995,0.013322732,0.0007701411,0.0148514155,0.02339051,0.04982563,0.0017839124,-0.011083945,-0.040098675,0.01785626,0.03394486,0.0019933186,0.00021657399,-0.07230733,0.0036874134,-0.01231375,0.021780007,0.008502987,-0.015926415,-0.06291803,-0.020006493,0.039148606,-0.0022847468,-0.0027475015,-0.044555206,0.0045902035,0.049531605,-0.0006219233,-0.011087026,-0.038401607,-0.0008923891,0.045302153,-0.029915947,-0.016471123,0.002382127,-0.012313765,-0.008325702,0.05013925,0.0513305,0.070207894,-0.01924501,-0.012277359,-0.0101903835,0.019760028,0.047077607,-0.001420148,-0.03358787,-0.047322113,-0.011444552,-0.00027453766,-0.070163675,-0.045083743,0.043279897,0.00074995,-0.00516166,-0.028683582,-0.00019522094,0.051830407,0.0051414045,0.002558286,0.07717142,0.04322143,-0.034723997,-0.012729537,0.010644638,0.013285026,-0.044497654,-0.045038346,0.001809335,-0.032612637,0.0020968677,0.0027857758,-0.030646054,0.057805408,0.013265334,7.407738e-34,0.06915976,-0.04695269,-0.07235444,-0.066680506,-0.02733401,-0.08726594,-0.0019448062,0.057793077,-0.057763577,-0.011147157,-0.06552442,-0.10562684,-0.025860304,0.07439727,0.0018298643,0.04765481,0.07260109,0.010414939,0.04564444,0.00493422,0.082436,0.007342083,-0.038024962,-0.05202146,-0.019211607,0.022334723,-0.04390262,0.007208225,-0.016300727,-0.00300953,0.020025808,-0.022581017,-0.050665755,0.026187522,0.13614799,0.059029717,0.018062305,0.014472566,-0.066041015,0.029614447,-0.016911503,0.067542985,-0.008336546,-0.0769565,0.037295733,0.012327273,-0.01430579,0.053360347,0.07838357,0.024846632,0.029906513,0.07640104,0.07795782,0.00064856675,0.06897579,0.042252373,0.06969103,0.0470495,-0.074211024,0.009039386,-0.107757136,0.08458086,-0.0050386055,-0.0057980344,0.024674702,0.054589365,-0.1652873,-0.0057656327,-0.005092401,0.058747053,0.021959335,0.011251086,-0.044258635,-0.008989563,0.019701188,-0.06763119,-0.051039357,-0.01054348,-0.015271812,-0.02878196,0.046435352,-0.008618403,-0.0449846,-0.086435795,-0.09196713,0.02037575,0.027787298,0.06122014,-0.06222638,0.029030845,0.026931223,-0.0159165,-0.008715148,0.023890702,0.021827567,-3.15753e-33,0.08582142,-0.04027226,0.05195125,-0.030806664,-0.033800855,0.12843189,-0.06284873,0.048094917,-0.0021933618,0.022054566,0.017261626,-0.01353927,-0.046935797,0.07038676,0.006140337,0.05254963,-0.022082534,0.049309846,-0.024851408,-0.017329995,-0.06905886,0.10244551,-0.00039581102,0.095945925,0.07947837,-0.041135244,0.03976548,0.100580335,-0.057855558,-0.04240506,-0.003834206,-0.01358492,-0.04457661,-0.06520842,-0.048033003,0.09096819,-0.036960162,-0.0077307485,-0.025060855,0.014464847,-0.013586156,0.038051907,-0.040116508,0.060570307,0.012508333,-0.005330158,-0.032404575,0.01585162,-0.035689835,0.03332073,0.046348065,0.022315271,0.017696308,0.07872579,0.053694766,0.06083785,0.01398906,0.034954537,-0.023556782,-0.103218384,-0.033371795,-0.04315948,-0.025588075,-0.0029217838,0.11574486,0.06889526,0.03631336,0.013894901,0.08245838,-0.030735822,0.075867735,0.08543492,-0.0050004846,-0.016795602,-0.009740274,-0.051430643,-0.046412326,-0.067632705,-0.10323737,-0.015309726,0.025899924,0.057493873,0.04316408,-0.14416893,0.00882395,-0.049345944,0.005281492,-0.01047915,-0.04581597,0.11268814,0.045047764,-0.047309075,-0.029712945,0.023091698,0.10980328,-2.5872456e-08,0.041159924,0.026955301,0.0040581645,-0.060942527,-0.029313378,-0.0020696013,0.06156394,-0.03508624,0.02409743,0.014940777,-0.008102763,0.124457575,0.041057706,0.07275558,0.090907395,-0.073946126,0.038678,0.051679235,-0.023100972,-0.020909954,-0.032452174,-0.016912583,-0.11151417,0.080703996,-0.010364142,-0.018118542,0.069622524,0.019392628,-0.012538347,-0.007787999,0.014789533,0.030537724,0.012100396,-0.055379577,-0.04312509,0.039030913,-0.010180729,-0.014717982,-0.06370381,0.07034833,-0.014519021,-0.06485204,-0.06923923,-0.014337702,-0.041334506,-0.042205404,-0.016103977,-0.013328221,0.009758232,0.042612493,0.04384569,-0.027056688,-0.019748366,-0.030287938,-0.056645755,0.009168524,0.035923094,0.007238543,-0.049285118,0.0089987,0.077364825,-0.07322889,0.20408009,-0.10635108 +4.2.1.100,"Forms part of the anaerobic benzoate degradation pathway, which also includes EC 1.3.8.6 [glutaryl-CoA dehydrogenase (ETF)], EC 1.3.7.8 (benzoyl-CoA reductase) and EC 4.2.1.55 (3-hydroyxbutyryl-CoA dehydratase).",384,0.99999994,-0.07441784,0.033283316,-0.036470678,-0.04637261,0.1527328,0.013533685,-0.06523526,0.0024519286,0.008862125,-0.06433796,-0.019326534,-0.10465776,-0.030763963,0.007495668,-0.07422984,-0.008150953,-0.11732713,-0.008204574,-0.06931387,-0.049836498,0.01201963,0.085740075,-0.0056252917,0.045400098,0.061044417,-0.076196864,0.03730354,-0.020708403,-0.10665725,-0.10197221,0.042512346,-0.0124133695,0.09540887,-0.034984667,0.06181532,0.09903748,-0.026163053,-0.094072625,0.033184256,0.067435324,0.009164507,-0.037864298,-0.04483465,-0.045562368,0.013694048,0.010173997,0.026624909,-0.009362813,0.0106561985,0.015523991,0.017382784,-0.037712064,-0.027895128,0.030928813,0.012477184,0.0075997454,-0.014926998,0.01283217,-0.1000839,0.06627144,0.044298597,-0.010325762,-0.022556683,-0.0017488927,-0.044288825,-0.035041783,0.092266686,-0.07971394,0.018366508,-0.00021008434,-0.12528977,-0.10084864,-0.029679835,-0.018444613,-0.046107974,0.06655553,0.022068795,-0.054293267,0.02160643,-0.09312336,-0.001589328,0.012429357,0.0636536,0.005004706,0.036108453,-0.041895732,0.012142753,-0.056938164,0.020948078,0.02095971,0.013545911,0.021703735,0.02222046,-0.000106336425,-0.023320258,0.08751959,0.049724467,0.048218474,0.04606461,-0.032665942,0.0071023162,0.10577376,0.01068052,-0.037833847,0.02284395,-0.009980683,0.057249762,0.15137504,-0.006435419,-0.02718971,0.0024616164,-0.01950388,0.05188137,0.017193196,0.0120044835,0.093260735,0.0030170088,-0.02242571,-0.059223257,0.06743493,0.013095617,-0.016300716,0.05911233,0.0264544,-0.025553808,0.009469073,-0.082267076,1.848996e-33,0.056830175,-0.023864476,0.02478179,-0.006182652,-0.015857443,0.009962229,-0.12958047,0.022748973,0.03280782,-0.096450835,-0.021703195,0.03115541,0.047484208,0.01498313,-0.073439986,-0.038856175,-0.010539606,0.032229442,-0.02421246,-0.009141092,0.02402102,0.048130423,-0.044796925,-0.060082115,0.057048295,0.010772428,-0.031262968,0.02703033,-0.025026202,0.005736521,-0.05004017,-0.075334325,-0.099825285,0.0056602275,-0.04614769,-0.005897996,-0.069074616,-0.00013368875,-0.0035058917,0.08794857,0.059517883,0.061835915,0.04248113,-0.023855017,0.006977681,-0.008137035,-0.031418726,0.1200124,0.048721176,0.032168858,0.019259343,-0.035548687,0.09917086,-0.048645545,-0.00558741,0.038861107,-0.02773322,0.028472848,0.0026060438,0.026619038,0.049863677,0.12168401,-0.076905176,0.026955632,0.036782183,0.0129544595,-0.086578764,0.012626856,-0.05797347,0.010891874,-0.049648486,-0.00912239,0.11760993,0.07742347,0.010597382,-0.06525631,-0.09454161,-0.010982727,-0.019209506,0.0077996925,-0.05496412,0.020944657,-0.0130090695,-0.046282794,-0.031565953,0.025331365,0.035373442,-0.013503805,0.060367603,0.012272658,0.009562228,-0.07635995,-0.03919668,-0.054514606,0.015570093,-2.1764441e-33,0.08864934,0.012484634,-0.009760282,-0.050089028,0.01577019,0.030703623,0.053484708,0.02992341,0.012153603,0.023357766,0.053957246,0.013388369,-0.02831051,-0.07835417,0.069511,-0.031229595,0.02249637,-0.0011915904,-0.047036674,-0.029081304,-0.03713063,0.007697257,0.0171643,0.008187072,0.057349794,0.018394228,-0.0019378744,-0.0024261822,0.017735817,0.011867101,-0.074908875,0.06465519,-0.026394315,0.030213153,0.0011337593,0.059187163,-0.093737714,-0.0004649402,-0.036116023,-0.030003792,-0.026944203,-0.020682514,0.025502184,0.047649857,0.08364621,0.06895978,-0.070929654,0.03516383,-0.01225443,-0.05358321,0.019555794,-0.031298432,-0.02399604,0.033045664,0.016168686,0.056939345,0.030398192,0.0070656934,-0.001631044,0.01153577,-0.009744541,0.04444641,0.058304723,-0.00773029,0.022453168,-0.0015465735,-0.03147908,0.117889315,-0.012313285,0.07507395,0.11093186,0.0073884684,0.06580943,0.048837885,-0.074895576,-0.023680214,-0.04786129,0.0069724917,-0.056028802,-0.06299209,0.053136013,-0.008376586,-0.029441133,-0.03702169,-0.038659584,-0.06818347,-0.023575254,0.025696967,0.014058639,0.0010343135,-0.009026467,-0.080311164,-0.09297863,0.1349424,0.019684928,-3.6878948e-08,0.0545045,-0.042733617,0.056091603,-0.03385253,0.05181241,-0.0047276635,0.039990332,0.07003842,0.10791414,-0.023720222,-0.014556255,0.043468338,0.06609303,-0.023834495,-0.028800836,0.01157581,-0.013568943,0.03830379,0.005304277,0.060568064,-0.07189564,-0.06456337,-0.13424242,0.04794712,0.050296903,-0.04626522,0.052748203,0.044504706,0.0004449371,-0.06268827,0.054901104,0.05244965,0.0607071,0.06945667,-0.03127046,-0.0053381105,-0.008385573,-0.030264312,-0.108919755,0.075788826,-0.03719878,-0.05909254,-0.06727947,-0.0332755,0.13094227,-0.012898822,-0.018890113,0.039962452,0.00056613894,-0.046006124,-0.022360971,-0.017540963,-0.009854996,0.025150761,-0.05980593,-0.009690508,-0.008774085,-0.03507903,0.04747772,-0.014703409,-0.0075806165,-0.01423312,0.18826477,-0.0038362169 +4.2.1.101,"This is one of the activities of a bifunctional enzyme, trans-feruloyl-CoA hydratase/lyase, that converts trans-feruloyl-CoA to vanillin. The other activity is EC 4.1.2.41, vanillin synthase.",384,1.0,0.0045069875,-0.03925161,-0.087973796,-0.045664523,0.10737666,0.00792525,-0.051052175,-0.0133219315,0.030241646,-0.046344526,0.013685337,-0.10786791,-0.10026434,0.04604104,-0.020669946,-0.02894724,-0.07638717,0.042261437,-0.028591027,-0.032428727,0.052701067,-0.0019718532,0.008704413,0.034456886,-0.004386517,0.0012282534,0.0709011,0.0015625611,-0.011936755,-0.08787635,-0.09796812,0.016538335,0.0052735526,-0.052392695,-0.01986684,0.06390975,-0.03469996,-0.026426107,0.046229657,-0.028624011,0.04996035,-0.13925998,0.00052819,-0.104809634,-0.05007413,-0.037298955,0.049601942,-0.052960727,0.063021675,-0.013835739,0.04843744,-0.030196788,-0.009005281,0.050340295,-0.03077246,0.0059964065,-0.048389602,-0.03258609,0.0052406145,0.02444881,0.005621973,0.051513746,0.007686779,0.0224322,-0.004855863,-0.061317652,0.053478792,-0.037516337,-0.03035185,-0.057428457,-0.02350896,-0.06943187,-0.020651374,0.037468582,0.032327853,0.058409236,0.019887585,-0.034741495,0.035489175,-0.02316985,0.03696357,0.027765635,0.02841517,0.04266166,0.021930115,-0.02038308,0.004118587,-0.024970416,0.05515462,0.033733808,0.023753233,0.017922757,-0.04155005,-0.04855225,-0.02302742,0.014304809,0.034017265,0.018248724,0.07440326,-0.016286585,-0.030592153,0.14345583,-0.011196995,-0.094656296,0.008707012,-0.0052565294,0.025524367,0.10920944,0.02348478,-0.03816736,0.04151074,-0.08430804,0.09564002,0.03969527,-0.016445192,0.027616182,-0.017955428,0.02134942,-0.09247289,0.12228656,0.03155501,0.013389757,0.041582596,0.08964452,-0.014980382,-0.0023590762,-0.07187223,1.8703574e-34,0.093926325,0.031593725,0.005093097,0.0271856,0.037853736,0.012986578,-0.13203315,0.038087238,-0.02778845,-0.04659322,-0.08185922,0.0013753627,0.043881617,0.06649746,-0.022289699,-0.06910648,0.04333008,-0.023814064,0.05059482,-0.0062009273,0.041834727,0.070679046,-0.025478762,0.019691883,-0.010424082,0.07380426,0.007044425,0.02682147,0.008872815,0.012400603,-0.07326972,-0.060765997,-0.03300998,0.018600939,0.036574703,-0.000722357,-0.040406026,-0.05316615,0.004384463,0.034795824,0.04604575,0.031528715,-0.023756761,-0.10257851,-0.009084242,-0.030118952,-0.0057110866,0.09737028,0.03160697,0.046301022,0.010969852,-0.045667414,0.0057426174,-0.07581822,-0.015175427,0.0112702865,-0.01907596,0.0057768635,0.049396854,0.06557239,0.019158993,0.080571495,-0.04061608,-0.009810177,0.019911325,0.03943868,-0.04761542,-0.13954462,0.021019377,-0.067833945,-0.06557884,0.01456431,0.091783606,0.02355009,0.09310527,-0.0027893414,-0.08519786,-0.02487538,0.06582784,-0.0011589493,-0.04172346,0.030379873,0.029666804,-9.902863e-05,-0.000507564,-0.016712848,-0.03148788,0.00091373164,-0.06516999,0.0035928779,0.012624338,-0.08979595,-0.06812131,-0.019526483,0.04336043,-1.9648212e-33,0.06921152,-0.09282194,-0.0021991408,-0.09847116,-0.04294117,0.048450492,-0.048169687,-0.06797662,0.03192259,0.03202771,0.06961382,-0.024264086,0.05316454,-0.051652,-0.027542552,0.008858086,0.021726789,0.010568193,-0.0271674,-0.028876413,-0.081575975,0.064958476,0.03853782,0.0425052,0.10229221,-0.009001934,0.012985655,0.030864224,0.0359111,0.07868285,-0.068518616,-0.031186553,-0.025304643,-0.025018452,-0.021100255,0.075926155,0.058311556,0.035303865,0.06903806,-0.009114356,-0.004366238,-0.012087552,0.039092153,-0.023694666,0.012478181,0.012690513,-0.073718965,0.015226203,-0.015378355,-0.058804225,0.043030113,0.028040092,-0.026694061,-0.012396698,-0.005897724,0.07260284,0.059660498,0.012859246,0.01611716,-0.05686407,-0.063738234,-0.033569712,0.029979626,0.0040752254,-0.014024616,0.064720884,-0.08217007,0.03195081,0.06314937,-0.056502093,0.15120707,-0.044454,0.089208,0.02600377,-0.0077547156,-0.10230393,0.023426006,-0.10978837,0.01001513,-0.06685576,-0.06103218,-0.0798428,-0.004607113,-0.054749936,-0.12041351,-0.06955329,0.046227783,0.06261554,-0.0231334,-0.009690743,0.01466865,-0.03138253,-0.079736024,0.08696768,0.07828176,-3.301079e-08,0.020310508,-0.040607452,0.023970058,-0.03182934,0.068036266,0.04742219,0.013938096,0.031050926,0.021135055,-0.022808528,0.0021628197,0.0772346,0.060929745,-0.022513306,0.045671765,0.08886074,0.03141425,0.083200395,-0.023826184,-0.04928779,-0.007533908,-0.061758235,-0.10092179,0.001276299,0.004204391,-0.07768573,-0.004850217,0.027517086,-0.03643282,-0.090537086,0.002979622,0.047258023,0.013455703,-0.027772393,-0.022966677,0.024187976,-0.01887875,-0.046636544,-0.06069765,0.06930887,0.02596635,-0.05018744,-0.07199898,0.009228521,-0.007324394,0.041821893,0.038825594,0.076992735,0.004525677,-0.061267406,0.09538198,-0.008897215,0.04853245,-0.018805668,-0.03218728,0.038702924,0.0027319423,-0.07094134,0.043338697,0.0100752,-0.009964924,0.08168239,0.16253877,-0.06820113 +4.2.1.103,The enzyme from Pseudomonas putida strain N19-2 can also catalyse the hydration of other isonitriles to the corresponding N-substituted formamides. The enzyme has no metal requirements.,384,1.0,-0.0904845,-0.033812232,-0.03465187,0.0135960495,-0.0012836842,0.04977851,-0.038615108,0.0021089776,0.003073121,-0.101888634,0.024598047,-0.048070595,-0.09361799,0.07231374,-0.004911454,-0.025657732,-0.039846107,0.012925611,0.05114831,0.021217419,0.09507246,0.053422656,-0.008660633,-0.015181793,-0.010710768,0.086522534,0.049767215,-0.044485718,0.08858532,0.005769447,-0.023871806,-0.09466135,0.020184241,-0.1306228,0.079433195,-0.01661489,-0.046717938,0.022385594,0.015916187,-0.055279553,0.022257002,-0.006972746,0.037793,-0.07022825,-0.003454743,-0.06706753,0.084698945,0.032135587,-0.0010092203,-0.01499945,-0.034291137,-0.07600832,0.06320744,0.0022113945,-0.0029705341,-0.023651699,-0.051204767,-0.035431005,-0.044282794,-0.03366811,0.060313992,-0.006843272,-0.053886436,-0.043245148,0.01850048,0.012694062,0.0037744448,-0.028295921,0.024533903,-0.006870174,-0.021243049,-0.032059688,0.039780654,0.0033616256,-0.03568616,-0.019779919,0.07841265,-0.0075087356,0.04512206,0.00603624,0.0043467814,0.021555873,0.0003910782,0.08812723,-0.02766399,0.037154723,0.020851428,0.045667116,0.09084765,0.012035791,-0.02691305,0.029906107,-0.005160174,-0.09014976,-0.05017594,0.053688154,-0.03896176,0.13072139,0.05934143,0.005168099,0.031709384,0.08505336,-0.07300144,-0.106940374,0.008644448,0.022602068,0.061819736,0.056964997,0.10093387,0.057560414,-0.02954308,-0.048340622,0.043508742,-2.3385099e-05,-0.04759911,0.018019216,-0.016825665,-0.052012194,-0.08191353,-0.04889888,-0.022715472,-0.083206154,0.03655214,0.03186655,0.051084764,0.030799102,-0.12027341,2.0774523e-33,0.05923213,-0.016948149,0.028701171,-0.00717128,0.018490339,0.016650686,-0.0530423,0.00799668,-0.01348972,-0.06712538,-0.11865696,-0.12012873,-0.025385669,-0.042767737,0.038412582,-0.04089097,0.023161922,0.047091026,0.091354184,-0.017330373,0.096522644,0.023457643,-0.008617364,-0.031115005,0.029587893,0.03843911,0.0579218,-0.033964306,0.0056637493,-0.024830075,0.03588532,-0.055940088,-0.08257515,-0.0031646,0.04341381,-0.012237808,-0.055510815,0.0431287,-0.00999511,0.08965458,0.052291937,0.06677635,-0.03544188,-0.010755301,0.11238882,-0.047428396,-0.030862385,0.19555794,-0.011849705,0.046898555,0.0024790002,0.023334734,0.0076291445,0.050376784,-0.046744205,0.024441337,-0.025043977,0.027661975,0.03410146,-0.006170473,0.01654796,0.010165276,0.019137455,0.0011152112,-0.013410518,0.007358031,-0.0069112894,0.043929107,0.079516426,0.027726345,-0.124651,0.018040663,-0.025477936,0.0779169,0.014240687,-0.11186774,-0.0063162446,0.014399103,0.118237354,-0.013886744,-0.031643394,-0.015368754,0.04883192,-0.0018527723,-0.024959732,-0.01977244,-0.042502217,-0.0022869578,-0.0117902225,-0.0334059,0.05565194,-0.14781766,-0.119038515,-0.01177374,-0.006439413,-2.8130757e-33,0.06643337,-0.113414675,0.029454587,-0.091915734,0.0007935637,-0.05532082,-0.06483854,0.008420331,0.038937505,-0.00880037,0.035751857,0.016286323,0.06438049,-0.023334013,0.017601395,0.054274134,-0.020782443,0.050324168,0.006168547,-0.06406515,-0.0100161005,0.006564954,-0.060006164,0.037738036,0.036832303,0.026891347,0.036935896,0.047355276,0.08450589,0.1145612,0.007963563,0.019618552,-0.039504237,-0.04427019,0.048919223,0.056018494,-0.0032375609,0.050949845,0.028030638,0.027022628,0.053008918,0.024357677,0.005839505,0.0630179,-0.04203913,0.0066326275,-0.1098487,-0.07654759,-0.025209237,-0.09616708,0.07573858,-0.0745034,-0.025757264,0.008516444,0.040882338,0.026573455,-0.013556773,0.02481181,-0.069249764,-0.0053621144,-0.009400309,-0.041248694,0.027396431,-0.018248085,0.008961675,-0.022502065,-0.037975375,0.055889234,-0.022569606,-0.019119155,0.008320854,-0.08224285,0.010715423,0.0390118,-0.01278588,-0.020476777,-0.003612189,-0.05669022,0.023002438,-0.034579363,0.0047616367,-0.032569956,-0.015173815,-0.047153093,0.07632944,-0.010730218,0.11066822,0.06322904,-0.093124665,0.043690316,-0.0066119195,-0.020575002,0.061858885,0.10561614,0.019875882,-3.187349e-08,-0.0034564855,-0.08041827,0.038566086,0.033803195,-0.09451628,0.08999913,-0.086544335,0.017934168,-0.018931497,-0.039781753,-0.017432665,0.023089759,-0.02277748,-0.00034274274,0.019882612,-0.0029712073,-0.03505826,-0.028315306,-0.09808462,-0.07083255,-0.0933358,0.004342055,-0.062353775,-0.018976275,0.0044579185,-0.039948255,0.035193387,0.025111822,-0.002630953,-0.024062334,-0.03154867,-0.014012387,-0.003981586,-0.019825034,0.0201209,0.033624973,0.0072111003,-0.042113896,-0.0288452,0.005834702,0.05119479,-0.071563706,-0.043828305,0.0052068112,0.06713669,0.011911117,-0.07504828,0.06821457,-0.061508793,0.012893305,0.059727624,-0.0093900915,-0.009695357,-0.03102731,-0.043761708,0.036149047,0.007588326,0.017784292,-0.034046732,0.07405698,0.028515385,0.03318349,0.17694837,0.015911464 +4.2.1.104,"This enzyme, which is found in bacteria and plants, is used to decompose cyanate, which can be used as the sole source of nitrogen [6,7]. Reaction (1a) can be considered an equivalent of 'cyanate + H2O = carbamate', where the water molecule is provided by the dehydration of bicarbonate to carbon dioxide [2], and hence the enzyme is classified as a hydrolase.",384,1.0,-0.09870161,0.0342224,-0.090937555,-0.04794281,0.017340433,-0.017861988,0.003155689,0.006817934,-0.01913207,-0.0129183,-0.041821685,-0.06700432,-0.06954237,0.008977653,-0.114714764,0.027550917,-0.058980726,-0.01584016,0.03638486,-0.038271938,0.07262358,0.0805015,-0.050995175,0.025186263,0.03283361,-0.0027237842,0.083090365,0.014527932,-0.0067023877,0.021265449,0.011922304,0.008728774,0.014041371,-0.065623626,0.010126481,0.065033145,-0.066250175,-0.056144845,0.028340757,0.04019298,0.02456365,0.023649763,-0.036148254,-0.03691272,0.021193763,-0.007979472,0.018319152,0.02206757,-0.020688018,-0.08287685,-0.039079193,-0.03582435,-0.095860064,0.037743703,0.036696747,-0.0077808406,-0.054428633,-0.019666027,-0.021909885,0.013049847,0.045485258,0.034925215,0.0045745396,-0.019583302,0.10197467,-0.06844405,-0.04551233,-0.08946498,0.016261414,-0.07745817,-0.077562384,-0.063417576,0.05064681,-0.043175936,-0.07082133,-0.044521388,-0.021661134,-0.004277681,0.03364608,-0.026290752,0.05517218,-0.021866372,0.0372819,0.05622073,-0.025531458,0.027330626,-0.029905355,0.018363042,0.085413404,-0.016080426,0.0100310575,0.042750273,0.008203266,-0.05541276,-0.04790391,0.030691812,0.06389312,0.021431372,0.06783545,-0.03486251,0.029997393,0.059136014,-0.02578142,-0.15244886,-0.09803838,0.093224846,0.09377055,0.12835884,0.11061465,0.0274628,-0.11073386,0.005074486,0.012553725,-0.011270953,0.0022659085,0.062889986,0.035148483,-0.00016241339,-0.04322196,-0.004741073,-0.011289502,-0.009926559,0.03518459,-0.001208751,0.002877677,0.09049127,-0.14116438,1.245696e-34,0.03224192,-0.037662372,0.031365324,-0.022899762,-0.003467634,-0.00817501,-0.063634925,-0.027531805,-0.0032676305,-0.1072347,-0.042423017,-0.029483087,-0.009975764,-0.012304072,-0.03353809,0.03125107,-0.057040475,0.0028198957,0.022167739,0.055247504,0.04267323,0.020456336,-0.059540927,0.018046556,0.03885335,0.053638734,0.06954747,-0.024691084,0.004299579,-0.036475535,-0.0036369015,-0.053261593,-0.0939775,-0.012947075,0.095413275,-0.06500239,-0.02532005,0.050718628,-0.06874459,0.02560902,-0.0039556823,0.025002912,0.043295532,-0.072719656,0.06827253,-0.031843815,-0.069038704,0.12919287,0.061681937,0.04507654,0.06750874,-0.024357058,0.07096367,-0.00015526643,-0.02550721,0.08120812,0.040607937,0.044162884,0.06951885,-0.002171746,-0.0055990694,0.038230047,-0.021868119,0.035373893,-0.048541293,0.02953586,-0.08465601,0.017962145,0.041291863,0.050944522,-0.09730714,0.011557341,0.05806016,0.033687726,0.03797535,-0.104818985,0.006659424,-0.021498758,-0.013235261,0.008367844,0.054990575,-0.04807226,0.0754101,-0.024604307,-0.0091006085,-0.00926059,-0.024948431,-0.042478196,-0.067121215,0.073445775,0.06509372,-0.07809378,-0.08622625,-0.05849206,0.06610015,-1.827281e-33,0.12871112,-0.06666314,-0.0162883,-0.029620469,0.026407043,-0.004628842,-0.00078979647,-0.12564993,0.022413107,-0.049576968,0.012876695,0.038852464,0.069927216,0.0023369808,0.0470984,0.011737318,0.0013360697,0.0757265,0.0008492378,-0.0490457,0.004636292,0.057566877,-0.0020314665,-0.07399967,0.08369982,-0.02999053,-0.01744897,0.09050369,0.06459744,-0.002616342,0.00029100847,-0.017271318,-0.011890916,-0.06864409,0.01313245,0.038132116,-0.015109974,-0.028139021,0.0028860648,0.015682586,-0.02960982,-0.04385831,0.030446243,0.068514265,-0.0076793954,0.0527925,-0.015996356,-0.04882749,-0.015327492,0.016473195,0.08640402,-0.026649933,-0.07550011,0.014474125,0.049431305,0.04265602,0.058067787,0.08889598,-0.012650277,0.017949104,0.047879312,-0.05240067,0.0366456,0.038227476,-0.006393246,0.044834074,-0.028221218,0.10440625,0.037884656,-0.021536086,0.06793997,-0.0013473238,0.042691246,0.09298464,-0.058101192,0.02002395,-0.024976406,-0.018441102,-0.047300097,0.00022074746,0.009530631,-0.0054257647,0.0014109794,-0.013314412,-0.033203837,-0.10199688,0.045417182,0.065600455,-0.072953455,0.005050225,0.013585193,-0.062439818,-0.047488786,0.03861104,0.03196665,-3.760516e-08,-0.072399184,-0.12720302,0.035750866,-0.049051475,0.0016035839,0.05036913,0.0067441687,0.02656042,0.059766404,-0.0905319,0.012184311,-0.0039869533,0.0107575925,0.08122165,-0.008043767,-0.024035886,0.0441711,-0.013054767,-0.055124916,-0.013832873,-0.06444625,-0.04447023,-0.13990305,0.06675481,0.021625884,-0.076021716,0.007209338,0.08384823,-0.009408129,-0.08262343,-0.022486812,0.042502217,0.056907926,-0.0419516,-0.05327832,0.051564943,-0.0073067294,-0.017601231,-0.03393585,-0.03915214,0.023686973,-0.03187901,-0.04043305,-0.03169812,0.014476904,0.017257778,-0.031237476,0.008515086,-0.0051585184,0.0253845,0.06436933,-0.021687686,0.036298923,-0.05012524,0.012003238,0.0325392,0.03435199,-0.017705293,0.011978599,-0.03858296,0.007191839,0.07862739,0.180411,-0.028531296 +4.2.1.105,Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.,384,1.0,-0.03916379,-0.052420232,-0.032068256,0.05664746,-0.026618954,0.041456826,-0.08987771,0.016692141,0.061628804,0.015410792,0.04135584,-0.028660227,-0.08766433,-0.071000025,-0.062662676,-0.012955543,-0.07304045,0.069265,-0.06766078,-0.012029481,0.029678822,-0.095295414,0.016778216,-0.09077017,0.04380882,0.04222434,0.0003733611,-0.010161723,0.06629891,-0.0650029,0.09435328,-0.02391891,0.067703664,-0.040789254,0.035370205,0.08570498,-0.055363834,-0.024394067,0.05186101,-0.012470325,0.032079753,-0.09412259,-0.032975063,-0.012609997,0.0844767,-0.04905812,-0.01001632,0.032507095,0.012465963,-0.0075954595,-0.032507043,-0.04772599,-0.05522535,0.013585507,-0.040104497,0.0028003375,0.031457335,-0.030689517,-0.028733144,-0.026912535,0.0011574328,-0.024684155,-0.025698425,-0.004410466,0.050932173,-0.06778906,0.014207204,-0.025605433,0.03238275,0.060925588,0.049915623,0.0026678618,-0.06575074,0.0056455447,-0.0060987957,0.051926017,-0.0335552,-0.043315135,-0.02827361,-0.030772375,0.093836844,0.055735134,0.10082811,0.06731134,-0.027321598,0.013628194,-0.032127123,0.029787488,-0.038043167,0.09477931,-0.056248084,0.059473097,0.030723952,0.008086627,0.00036825,0.0820315,0.04062574,0.08372376,0.05413252,0.0035469076,-0.04391507,-0.039650716,-0.05614966,-0.07647408,-0.016662074,-0.0008359414,-0.08655239,0.026010053,0.05018142,0.027763857,0.0024028134,-0.05073774,0.0032814299,0.001830273,-0.0011947425,0.06635254,0.03376992,-0.0027513397,-0.00035308828,-0.0024424368,-0.036319952,0.047370724,0.0184723,0.060493097,-0.12751453,-0.03882085,-0.030716347,-2.3356654e-33,0.06743484,0.0308072,-0.025584571,-0.017275244,-0.015947802,-0.0019312988,-0.03510357,-0.02173163,-0.00513531,0.03257517,-0.13821052,-0.06311161,0.00115172,0.009395826,-0.07289548,-0.014281925,-0.047068223,0.02080284,0.017028322,-0.07937872,0.007561968,0.024342071,-0.019532798,-0.03954042,-0.029097946,0.013285177,-0.088579446,-0.03952425,-0.014467848,-0.023310913,-0.06487723,-0.06282544,-0.0917499,0.009642302,0.0013868262,-0.014942247,0.0010953074,-0.06116334,-0.11186637,0.029644417,0.036968596,-0.025637427,-0.03648675,-0.08709618,0.07627136,0.035800993,-0.037265427,0.12245329,0.08147133,0.060227208,0.075802095,0.013860096,0.11880645,0.05064781,-0.07052318,0.049338307,-0.0168851,-0.11621472,0.046344396,0.06772822,0.022034854,0.056533325,0.029175611,0.04573349,-0.046664238,0.048493404,-0.03518175,-0.035972178,-0.012458276,0.033836924,-0.0213901,-0.084090136,0.050162606,0.0058767535,0.05647894,0.015274531,-0.046831645,-0.04590129,-0.021788942,0.01608981,-0.048579115,0.025529774,-0.030478885,0.0052662506,0.0023824756,0.036096547,-0.055262085,-0.04055431,0.0042813765,0.046432626,-0.017772745,-0.041472666,-0.05421313,0.05204586,0.056409992,-1.9408757e-34,0.08342644,-0.10283177,-0.046760287,-0.059146993,-0.056973673,0.057660315,-0.058106314,-0.067354,0.0044623846,0.08124925,0.034136117,-0.085496075,-0.0008277743,-0.0057844296,-0.036000412,-0.043140184,0.068570375,0.113161586,-0.025425661,0.0031675098,-0.03751024,0.010043345,-0.05477662,0.12729825,0.06757688,-0.010214401,0.10543011,0.0053506508,-0.012145617,0.12673615,0.014294982,-0.0026200565,-0.042682867,0.03949001,0.051415846,0.106616944,-0.07269733,-0.03719069,0.044696018,-0.01695884,-0.029125594,0.03963464,0.018431239,0.08221258,0.062289145,0.008916025,-0.018223029,0.028778551,-0.06641507,-0.06790188,0.06586919,0.047118,0.0048625246,0.017608948,0.014512772,0.11350768,-0.00085334474,0.014898111,0.04926766,-0.030329475,-0.008813626,-0.068423145,0.06352216,-0.0383856,0.071396545,0.08139882,-0.005732091,0.086252525,-0.040883075,-0.0006722907,0.074810416,0.0130423615,-0.038162574,0.089316,0.043804005,-0.0033000675,0.015356578,-0.053740952,-0.01201801,-0.07504547,-0.043699395,-0.03572401,-0.009856072,-0.103047945,-0.020373313,-0.063682,-0.028985253,0.05570282,-0.0046792515,0.04756631,0.035602186,0.0043910337,0.016511392,0.051055297,0.056274995,-2.4359746e-08,0.013880373,0.024602309,0.077824816,0.020266883,0.02792572,0.05087243,0.022582136,-0.011737978,-0.0054215216,-0.033843007,-0.03575185,0.052162703,0.055580113,0.039120074,0.027725196,0.03886221,-0.028876223,0.028183317,-0.04609563,-0.046033204,-0.094114676,0.016278738,-0.09255467,-0.043700855,-0.0035360036,-0.100183316,0.035658285,0.039958563,0.07635186,-0.0039581885,0.07310604,0.013950982,-0.044242237,-0.037301112,-0.065382294,0.08248339,0.06844676,-0.077947505,0.016278466,-0.08287217,-0.07793892,-0.0068266275,-0.024240488,-0.033613153,-0.036286667,0.04303421,-0.020606617,0.03879835,-0.05477614,0.017155837,0.023467746,-0.0046530534,-0.023934705,-0.010220042,-0.045703474,0.0060417308,-0.022683391,0.006040003,0.053322293,-0.051069017,0.019726742,0.044526305,0.151877,-0.026515376 +4.2.1.106,"This enzyme, characterized from the gut bacterium Clostridium scindens (previously known as Eubacterium sp. strain VPI 12708), participates in the 7-dehydroxylation process associated with bile acid degradation.",384,1.0,-0.049868595,-0.043415703,-0.099236034,-0.0437452,0.0129895555,-0.045427997,-0.059847016,0.073391035,0.022652134,-0.066280626,0.026191501,-0.033701394,-0.03916036,0.021890344,-0.06646573,0.015962627,-0.016278474,-0.023001377,-0.0059468644,-0.021304881,0.037287306,0.041366037,0.009078998,0.040147424,-0.035681948,0.026935095,0.115875795,-0.0019439524,-0.03946429,-0.037712365,0.02591715,-0.026302017,0.051665496,0.0047513107,0.038784176,0.072123855,-0.014812488,-0.020234216,0.07989914,0.029758407,0.06291245,-0.032007203,-0.04606104,-0.06789764,-0.029691737,0.00040597003,-0.025914239,0.032653775,0.028871542,-0.023824919,-0.023772566,-0.041717675,0.04178577,0.005611833,0.021387449,0.026685795,-0.011508633,-0.13752179,-0.001991495,-0.0013238916,0.040921725,-0.012522439,0.046174213,0.0063067675,0.01949376,-0.05436336,0.08966583,-0.10396462,0.018693399,-0.053112876,-0.1311676,-0.05529663,-0.044305753,0.069576845,-0.024253096,0.042929318,-0.04692541,-0.07613692,0.035445355,-0.09362534,0.008350574,-0.01238481,-0.03885325,0.06633345,0.028834617,-0.030954998,0.07816516,0.0041557173,0.06215947,0.01749996,-0.030214988,0.005851886,-0.016210275,-0.04087335,-0.03707175,0.031597335,0.0050332868,-0.016222494,0.04160895,-0.018633375,-0.019397823,0.09424326,0.0035995797,-0.078432776,-0.07039041,-0.062014036,0.071493916,0.12044512,0.026880695,-0.02953238,0.016360579,-0.035002083,0.05942066,-0.06942112,-0.018739305,0.10319279,0.05237225,-0.024763005,-0.017749852,0.05275638,-0.0012954862,0.017531183,-0.033893205,0.07624173,-0.02218259,0.078051,-0.06357239,1.4864447e-33,0.015984753,-0.002276222,0.002525611,-0.016494941,-0.0067618284,0.00742763,-0.11663109,-0.0013396093,-0.024318462,-0.073771216,-0.022901703,-0.05677699,0.060768325,0.05123155,-0.03804655,0.03137211,0.011406281,0.05822097,0.07801516,0.0037446537,0.041071944,0.016886033,0.008454276,-0.03719226,0.052715316,0.059602693,-0.010487353,0.025043968,0.0046020015,-0.024383586,0.020509707,-0.074172944,-0.06552566,-0.0013138842,0.06314359,0.030303922,-0.030729441,-0.020615809,0.020032119,0.08305203,0.052708548,-0.0059450287,-0.008667996,0.0061201565,0.042732343,-0.02633711,-0.04806464,0.11314018,0.04951474,0.02298649,0.050490454,-0.019530248,0.046599425,-0.098602615,-0.044199295,0.012097664,0.050433274,0.04846353,0.039833248,-0.0015810523,0.019762874,0.13901378,-0.1144254,0.06272734,0.035809413,-0.049992196,-0.04576664,-0.01583662,0.0012308366,0.026027739,-0.15417117,0.005091116,0.047884263,0.040965483,0.020277325,-0.049346518,-0.09893344,-0.039892353,0.03622839,0.033127345,-0.10969522,-0.029610997,0.016525727,-0.039540857,-0.027287306,0.009880568,-0.11216612,-0.030720372,-0.030700933,-0.010264979,-0.0036254497,-0.06256492,-0.070994385,0.036258988,0.014617799,-4.4164425e-33,-0.0054540774,-0.07091527,-0.0036700729,-0.008106001,-0.015171699,0.054951742,-0.04085654,0.04704932,-0.008834805,-0.046145752,0.1027948,0.016847542,0.07536868,-0.046928547,0.086884126,0.088941306,0.0066397367,0.037284218,-0.03060336,-0.04270787,0.016562667,0.12340394,0.05798264,0.038707808,0.017148435,0.015594743,0.08695873,0.051920522,0.03249116,0.054853205,-0.0009063186,0.05060463,-0.028377438,-0.0031065876,-0.04663452,0.037796903,-0.071628585,-0.025276342,0.047107495,-0.07416587,-0.028410977,0.0023698593,0.011662445,0.0069864327,-0.028484585,0.06057417,-0.00018801438,-0.015712129,0.017206613,-0.0063949404,0.00997781,0.0149573255,-0.00016980672,-0.0052990736,-0.011024319,0.02840176,-0.06376766,-0.011450895,-0.020602588,-0.0886434,-0.049033675,0.0032535607,0.08789408,0.056884427,-0.01114623,0.058760248,-0.032088898,-0.015951714,0.0014926195,-0.10441661,0.08262691,0.026200715,-0.06524372,0.040094443,-0.042917755,0.019948775,-0.06859631,0.025707673,-0.018802999,0.033131637,-0.015876498,-0.03558466,-0.026499193,-0.068784684,0.038140975,-0.0679949,-0.10401449,0.0859824,0.039873898,0.036886368,-0.015329728,-0.04675451,-0.10482231,-0.004957545,-0.009431783,-3.096975e-08,0.064935245,-0.09696486,0.06364425,-0.015246774,0.038847264,-0.0024851828,-0.03252302,-0.008520276,0.03690165,-0.0555138,0.015315554,0.10452522,-0.010240959,0.026126163,0.038443413,0.061010838,-0.042203166,0.024682771,-0.020312687,-0.018213753,-0.06178305,-0.0556235,-0.039104313,0.06525229,0.0343735,-0.04230883,0.050028488,0.02908484,-0.00886422,-0.14956738,0.05104333,0.041209307,-0.023166237,0.015994651,-0.049748924,0.05392631,-0.0065162517,0.01517959,0.0043682987,0.09181909,0.032770317,-0.030136479,-0.11958502,-0.034106355,-0.021639489,0.035432957,-0.06986786,0.05766494,-0.027456947,-0.040470913,-0.033904746,-0.003908629,-0.0029546747,0.06739808,-0.061714638,0.014379709,0.0038589605,-0.095691316,-0.004402518,-0.03852823,0.044011705,0.01745698,0.20701754,-0.031389598 +4.2.1.107,"This enzyme forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity. The enzyme is involved in the beta-oxidation of the cholesterol side chain in the cholic-acid-biosynthesis pathway.",384,0.99999994,-0.005476476,-0.0849123,-0.050200112,0.023659669,0.008535212,0.002227122,-0.11118531,0.01783541,-0.0035058844,-0.045778103,0.023160977,-0.023594175,-0.06520236,-0.03157516,0.025364451,0.09418176,-0.081681296,0.0008414628,0.10125431,-0.03323848,0.00022671015,-0.032886885,-0.034156337,-0.081096224,-0.03776031,0.059128746,0.12410643,0.02027637,-0.01861162,-0.093017265,0.05823635,-0.050159287,0.040748656,-0.00844132,-0.052502785,0.04930454,-0.05910069,-0.028099291,-0.01496689,-0.020465601,0.024712402,-0.02653953,-0.093963265,0.009744369,0.022215486,-0.081604086,0.064524926,-0.011939323,0.01476715,0.021839403,-0.03966658,-0.018725544,-0.024547135,-0.019316712,0.013404588,0.022462234,-0.027732447,-0.035962306,-0.04304388,0.018899312,0.0053585344,-0.02945363,-0.033946842,0.0003674478,0.03690074,-0.014369455,0.07020544,-0.035650127,-0.01653325,-0.13455842,-0.0047290786,-0.056333955,-0.027593544,-0.05430691,-0.023743588,0.040307064,-0.08440095,-0.005378666,0.08050184,-0.05942828,0.019011822,-0.04016082,0.038852926,0.058529396,0.06853299,0.03248809,-0.022658305,-0.03946633,-0.057837766,0.055256706,-0.008972633,-0.02243707,-0.055250242,0.016600696,0.010182276,0.04252213,0.04265997,0.067740425,0.022815978,-0.040496733,0.020148745,0.080461524,-0.03771815,-0.042448174,0.03954969,0.02743785,-0.013961881,0.039871447,0.04215284,0.010350846,0.01700603,0.05242535,0.042385306,0.046547316,0.024251044,0.08739816,0.059721295,-0.032538183,0.047286734,0.060507502,0.019123364,0.0049834875,-0.07131926,0.033231426,-0.056098077,-0.008744549,-0.04969729,1.5223649e-34,0.022607699,0.019791095,-0.0032068326,0.032340065,0.030070493,0.02778711,-0.08201364,-0.010315799,0.028521534,0.0058871643,-0.010170601,-0.051413745,0.007264222,0.019555714,-0.047008365,-0.07086891,0.016275853,-0.015763395,0.13939765,-0.020895695,-0.013369203,0.07708796,-0.065560386,-0.017068027,0.02099259,0.071539916,0.0070594708,0.027488526,-0.024767822,0.017603312,-0.012083794,-0.07525115,-0.05277049,-0.05931253,0.034859285,-0.06719811,-0.060982328,-0.011745944,-0.07173507,0.024150567,0.0121725965,-0.050222684,-0.05234175,-0.041317288,-0.016313491,-0.077485494,0.0021559407,0.07159209,0.03462666,0.06014155,-0.0010324334,-0.0036650826,0.06360899,-0.01862293,-0.011266223,0.0057708663,-0.0072700344,-0.013858231,0.014362751,0.06918953,0.005112433,0.07949441,-0.082882084,0.04120349,0.011169821,-0.027396182,-0.08766291,-0.0195384,-0.03190797,0.0725317,-0.00997,0.039638318,0.061597604,-0.022911195,-0.0081861075,-0.0071124816,-0.021622892,0.082897,0.05630437,-0.07704237,-0.011435659,0.02744869,0.016987374,-0.061444618,0.020670995,0.102451146,-0.049280215,-0.07937118,-0.0021187344,0.06639597,0.0564731,0.012516572,-0.09331765,0.033153962,0.043668374,-2.8031804e-33,-0.0402868,-0.061965927,0.013917353,-0.10277664,-0.018153973,0.118839465,0.017876893,-0.0028907359,0.052002404,0.008039659,-0.016775986,0.036658112,0.041285902,-0.103883095,0.056737226,0.097142294,-0.026201652,0.0683571,-0.037670996,-0.036973726,-0.015815817,0.14693949,0.08248047,0.13936235,0.026457148,-0.012974019,0.054232724,0.011033854,0.07104333,0.09597252,0.06443236,-0.025591312,0.020984907,-0.019845895,-0.041526616,-0.033462122,-0.056685153,0.060590632,0.023017641,0.013499346,-0.04440306,0.037606735,0.016726026,0.025333853,0.00048744972,0.04504415,-0.029131195,-0.025657186,0.0010129322,-0.09508099,-0.05015921,-0.023421163,-0.028999506,0.022768976,0.0122832,0.043850403,0.008633862,0.010976621,0.09096217,-0.06470797,-0.095173016,-0.032640062,0.062312484,-0.0147205815,0.023760196,-0.00017003388,-0.012254932,0.0012511361,-0.029753111,0.024791414,0.062634125,0.0685223,-0.061787937,0.057519857,-0.026202584,0.07548984,-0.061150845,-0.023485992,-0.016438222,-0.02515828,0.00893504,0.013878559,-0.01716149,-0.06285299,-0.10352924,-0.13294178,-0.0028279554,0.12200297,0.06231476,-0.033484124,0.05521811,0.04693486,-0.1657206,-0.00014186827,0.081002116,-3.2784378e-08,-0.06418936,-0.10422819,0.05676593,0.016194846,-0.040082008,-0.053606763,0.063502744,0.026362466,0.033987142,-0.016835002,0.018286642,0.1284814,-0.00826395,-0.021039208,0.0029333977,0.042818256,0.052555807,0.047483403,0.013187379,0.022724178,-0.048806604,-0.054303505,0.011037043,0.041306026,0.03550499,-0.080604054,-0.009826727,-0.0034816714,0.033786234,-0.010525768,0.0029641013,0.018850511,-0.03269021,-0.032683875,-0.08295601,-0.007366096,0.051833823,-0.02507656,-0.018797683,0.046311755,0.04565281,-0.069819115,0.008642666,0.01860784,-0.06783676,0.031215224,-0.044299472,-0.00096151064,0.007099881,-0.0665646,-0.009436445,0.029427651,-0.019253625,0.0018899539,-0.09826089,0.010802676,-0.07875048,-0.049575858,0.04056584,-0.08428088,0.04616031,0.100126565,0.14765093,-0.05012118 +4.2.2.1,The enzyme catalyses the degradation of hyaluronan by a beta-elimination reaction. Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose,384,1.0,-0.06977715,-0.026973689,-0.055121664,0.01999063,0.019239971,-0.0027392316,0.0122465035,0.036826964,-0.02889122,0.08668168,0.022728376,0.095052026,-0.046149462,0.021522414,-0.10907297,0.06419009,-0.07653424,-2.5178844e-07,0.04528076,-0.05291173,0.08725476,-0.02962716,-0.014444495,0.007394934,0.039410558,0.008125382,0.06465437,-0.0366847,-0.08324771,-0.016676305,-0.06674804,-0.0022171484,0.009932211,-0.015419536,-0.03273225,0.105762154,-0.09464033,-0.08678848,-0.024581734,-0.0068037785,0.0040033218,-0.0050127297,-0.043294195,0.037732415,0.02743927,-0.09000822,-0.018799992,0.040352203,0.044380035,0.047226716,-0.022208683,-0.0027038709,-0.0014761,0.0021029538,0.0044894074,0.022665247,-0.11832349,-0.050092813,0.028452625,0.056498423,0.042639885,0.03726468,-0.046974737,-0.031200254,-0.0057480903,-0.061666287,0.08476665,-0.11114726,-0.06138777,0.0417098,-0.04451388,-0.02495071,-0.016631246,-0.058518246,0.05497716,-0.053160403,-0.024287766,-0.04119024,0.042477604,-0.017032625,0.068422854,0.038442113,0.07920549,0.12804613,-8.232871e-06,-0.00022248748,0.016862545,-0.024602855,-0.010572049,-0.005151609,-0.05638512,-0.0064677214,-0.031031651,0.017812725,-0.052667473,-0.016160136,0.017252883,0.054643165,0.036780592,0.037112143,-0.057938796,0.027211143,-0.046420395,-0.13290809,-0.03704261,0.018846417,0.0050273365,0.075017035,0.111731015,0.06577786,-0.024415452,0.0041470025,-0.0009816103,0.029199053,-0.057310533,0.15458328,0.04969573,0.0101392865,-0.055543933,0.033239413,-0.0010402887,-0.00090115523,0.043204844,-0.06336953,-0.03535776,0.005053666,-0.0016341415,7.778646e-34,0.041679904,0.022971248,0.012575052,0.018526083,0.0033734972,-0.013527279,-0.0563883,0.011112937,0.04242194,0.033559084,-0.088701256,-0.021422988,-0.042474598,0.064580195,-0.0123420805,0.013546483,-0.008001195,-0.031431958,0.07146585,-0.008498317,-0.0009834323,0.09198479,-0.036623884,0.043649886,0.00032635062,-0.022241661,-0.031148711,0.08126412,0.08478118,0.011406428,0.08441318,-0.046656188,-0.048245434,-0.09394963,0.012405063,-0.005197417,-0.05990357,-0.023260145,-0.021948012,0.021333583,0.02272405,-0.019309968,-0.01868891,-0.09389954,0.009723167,-0.03164051,0.08003426,0.079234,0.039037455,-0.039438672,0.039578307,-0.0008378833,0.09713601,-0.0041769054,-0.049974684,0.022585994,-0.032841,-0.05648749,0.07127977,0.07022149,0.009426748,-0.037610635,-0.035418734,0.042866822,0.01876259,-0.0073777298,0.017012937,-0.051367406,-0.065347746,-0.03758451,-0.04030905,0.026155671,0.005700764,-0.0031162598,-0.029719003,-0.0058059026,0.01924793,0.064822175,0.024323426,-0.052728992,-0.056691766,0.02719759,-0.0077122613,-0.0243135,0.06793044,0.040712163,-0.059956193,-0.029701345,0.055466354,0.060067534,-0.09666156,-0.047322717,-0.07609627,-0.01573071,0.02608257,-2.1560526e-33,-0.02931534,-0.0745811,-0.0086761955,-0.02236648,-0.033105914,0.10096758,0.043891486,0.042555515,0.045647774,-0.022339765,0.060094994,0.007300955,0.025471492,-0.07601809,0.029320354,0.06181188,-0.08538055,-0.0035057839,-0.08331543,-0.01466809,0.013850595,0.13305445,-0.02054592,-0.04877826,0.029168503,0.023229115,-0.03136717,0.03101671,0.041034415,0.122203045,0.0045771925,-0.10980778,0.009602465,0.020955442,-0.06152968,0.079912804,-0.040184908,-0.027221544,0.028837362,0.021505632,0.0058066766,-0.038989298,0.07950437,0.034135904,0.10607544,0.05492827,-0.11199301,0.012005583,-0.0336609,-0.014127802,0.01903138,0.039245617,-0.021028064,-0.016311198,0.04792294,0.08469228,-0.016983114,-0.014496985,0.031586654,0.0075540347,-0.0050020227,0.0057447646,0.054705817,0.03351525,0.039014466,0.049243584,-0.018814469,0.0020326187,0.03150954,-0.03489965,0.07033509,-0.017849263,-0.009660088,0.058660198,0.06891637,0.0016365129,-0.042771965,-0.01344031,-0.037070047,-0.04297838,0.049374823,-0.023399524,-0.0029368897,-0.054910228,-0.05486249,-0.0056349607,0.056517377,0.09065095,0.018788524,0.07134825,-0.0076708756,-0.0048148124,-0.074572735,0.0110533405,0.04425093,-3.8223654e-08,0.0695419,-0.03585656,0.063013636,-0.08155267,-0.037603155,-0.04759511,0.06009856,0.10550698,0.04975888,-0.03389555,-0.016849592,0.13901098,-0.044510487,0.009702915,-0.04495487,-0.020438679,0.045384914,0.08331513,-0.06405435,-0.06584366,-0.10146077,-0.011670026,-0.017388923,0.061522085,0.0092925355,-0.12411119,0.0123139145,-0.0005377334,-0.13624568,-0.0046515707,0.0333184,0.05608819,0.007709451,-0.060104135,-0.08721901,0.026410157,-0.010860277,-0.024097443,0.042787395,0.024695825,-0.03147907,0.0046339827,-0.004923213,0.011470567,-0.04143998,0.017692743,0.022740478,0.016282154,-0.042873926,0.063955195,-0.01637088,-0.019916153,-0.108951196,-0.08143629,-0.09089008,-0.042570453,0.029034339,-0.026822621,0.040645827,-0.09281376,-0.024459878,0.0049124104,0.14245833,-0.012164189 +4.2.2.2,"Favours pectate, the anion, over pectin, the methyl ester (which is the preferred substrate of EC 4.2.2.10, pectin lyase).",384,0.99999994,0.008647665,-0.03198065,0.008864154,-0.042387407,0.052455287,0.041123427,0.028762134,0.040104825,0.028729549,-0.012157987,0.083048016,-0.10897684,-0.103592634,0.01463646,0.032092545,-0.020461367,0.013086311,-0.02082483,0.01615425,-0.05644869,0.05911697,0.0042953645,-0.012523761,0.013601007,-0.06713482,-0.05284453,0.011510784,0.041873414,0.03074664,-0.15444618,-0.029946953,0.067019224,0.12203474,-0.08537935,-0.075818166,0.06490571,-0.01582858,-0.11700101,0.007736603,-0.021545582,0.057726514,-0.00068570493,0.047418173,-0.039750665,-0.055869393,-0.04841852,0.08717179,-0.057481386,0.055419564,-0.07404518,0.030879345,-0.08885968,-0.027321294,0.0011198686,0.019021327,-0.007392751,-0.07008425,0.0013687693,-0.018430123,0.022432752,0.008569543,0.05578703,-0.050910123,0.024128344,-0.090670735,-0.025515467,0.0900271,-0.062296916,-0.08798142,0.051534086,-0.068880074,-0.03971804,0.014158994,0.033221073,0.046488672,0.08783036,-0.001229244,-0.15523212,-0.042934608,-0.008861605,-0.029908217,0.04082373,-0.03206767,-0.015079797,0.015489284,-0.062140003,0.035028014,-0.058658354,0.0052121477,-0.00073937245,0.14406168,0.03770789,-0.0140061,0.025014132,0.020933194,0.059140854,0.016372908,-0.0162663,0.048223358,-0.024806967,0.02884137,0.08200301,-0.014439152,-0.044386026,0.001792894,0.023216913,-0.015859684,0.02639209,0.09945194,0.016701803,-0.030154768,-0.022023292,-0.020556135,-0.012013117,-0.096937455,0.0058791055,-0.0005869825,-0.048616998,0.027895307,0.027633177,-0.009222635,-0.042226303,0.02465911,0.088904746,-0.044898927,-0.0485624,-0.10185638,-1.4426303e-33,0.0024757076,-0.018007567,0.03178994,-0.035767242,0.002269038,0.021325078,-0.09577617,-0.015274334,0.03044211,-0.119191654,-0.11659975,-0.0135884425,-0.037725393,0.1456338,0.0067079673,-0.08222449,-0.032370154,0.0025517636,0.006720319,0.024352062,0.0005444938,-0.0039990433,-0.090656064,-0.03081819,0.071345955,0.0014872935,0.06577421,-0.022266673,-0.0027611663,-0.00479652,0.011607727,-0.08299945,-0.036509827,0.04881298,-0.025093481,0.040433384,-0.02635456,0.019970048,0.012792738,-0.020702979,0.07293282,0.071870066,0.09276274,0.015072622,0.047745507,0.020763483,-5.4965523e-05,0.06268235,0.022424838,0.055159234,0.04649496,-0.052403737,0.01921038,0.0138218,-0.04561662,0.026779618,-0.06377402,0.00024824907,-0.04344861,0.025502048,0.0063101477,0.100473225,0.033923097,-0.00025753985,-0.034855336,0.08042205,-0.10707105,-0.07188632,-0.032042965,-0.0069975713,-0.08409213,0.017763717,0.1152578,-0.011774672,0.025608903,-0.046343938,-0.06963322,0.051361773,0.017028783,0.03362982,-0.0113229,0.008378726,-0.018229187,0.015305308,-0.09733321,0.0038079952,0.0066738226,0.101400055,0.10835662,0.059239537,-0.0065497784,-0.013631948,0.017251002,0.040283337,-0.048699424,-2.6832785e-34,0.068822116,-0.077373505,0.10108969,0.050941207,-0.031148389,0.016783664,0.09782104,-0.00040989468,0.009137534,-0.071996994,0.03513816,-0.0061337743,0.047713537,-0.098926805,0.020454314,0.07418792,-0.08663417,0.08542306,-0.031008745,0.015131414,-0.09960977,0.046918675,0.03440846,0.051470358,0.10550767,-0.013459212,0.02861467,-0.012493667,-0.020783335,-0.01614448,-0.087954305,-0.05503106,-0.0649584,-0.044696137,-0.08139495,0.026104081,-0.0077420436,-0.020329572,0.007543598,0.058160543,0.03284086,0.07125795,0.020921098,0.048070543,-0.043520983,0.06657406,0.00492928,0.02993072,0.039504535,-0.00573346,0.008535685,7.417617e-05,0.031524908,-0.045628738,0.02482096,0.057732496,0.008949921,0.034405265,-0.04804923,-0.0023192416,-0.0523291,0.015701964,0.05665638,-0.06871136,-0.0013267383,0.025177069,-0.06444677,0.015693597,0.032153346,-0.002331925,0.08869138,0.010029546,-0.021523874,-0.0016819772,-0.013292976,0.012590121,-0.029222114,-0.10142834,-0.060772803,0.032242034,0.008825392,0.028101727,-0.07090237,-0.0012353192,-0.019331338,0.024619248,0.042042404,0.0049694297,-0.03406261,-0.010760642,-0.011269922,-0.023255683,-0.03075809,0.094598606,0.06767254,-3.075047e-08,0.0027527602,-0.063830964,0.045262765,-0.03434948,-0.018115517,-0.0024949939,0.07710363,-0.00020645054,0.016243171,-0.06272067,-0.007939635,0.05843387,-0.03830055,0.065434,0.05645742,0.02089204,-0.042359207,0.03289877,-0.031801503,0.0405686,-0.09039157,-0.026604876,-0.10213711,0.036542837,0.010799931,0.00027410957,0.0821782,0.06195978,0.01598044,-0.009910529,0.019301545,0.051630486,-0.08031147,-0.0010322548,0.0054490864,0.023549918,-0.048061617,-0.021472638,-0.08934401,0.08831421,0.05763315,-0.094443105,-0.008927199,-0.012019741,0.011783792,-0.032861575,0.0020479283,0.060484566,0.024275713,0.017681234,0.07827874,-0.023661895,4.3276505e-05,-0.002275989,6.547331e-05,-0.043354027,-0.005978619,-0.042729884,0.009920658,0.01304432,0.030825043,0.010328203,0.12695177,-0.015197157 +4.2.2.3,"The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between beta-D-mannuronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to four residues, with preference for shorter products. cf. EC 4.2.2.11, guluronate-specific alginate lyase.",384,0.99999994,0.005841903,-0.0492937,0.010177245,-0.0071020005,0.0025318905,0.047978126,-0.01583209,-0.012377921,0.068050645,0.10302585,0.035366762,0.03432736,-0.0335384,-0.05928719,-0.12849408,0.0580286,-0.024528591,0.007843926,-0.02598771,0.015780587,0.15646483,-0.0043258816,0.0043062023,-0.008102993,0.079026006,-0.037904967,-0.0014504392,-0.10521768,-0.02069674,-0.08115131,-0.007425647,-0.016623402,-0.009373949,-0.024306605,0.0074719093,0.07184069,-0.016203292,-0.084863685,0.061450165,0.00789892,0.03228423,-0.0074745202,0.009930026,0.01752904,-0.05877833,0.025772206,-0.009132069,0.07096827,-0.011347612,-0.0445735,0.01499152,-0.10092666,-0.039315954,-0.00010129737,0.051971123,-0.028521275,-0.057755355,0.019591816,-0.019098695,0.12843366,0.06996465,0.04978508,-0.0018146856,3.472164e-05,-0.04979141,-0.070304744,0.0951456,-0.036180165,-0.042713683,0.056051705,-0.03804311,-0.023443682,-0.0076493556,-0.0002692958,0.08430012,0.035280198,0.03533427,-0.11902629,-0.03486052,0.042471323,0.016891684,0.013511909,0.091779396,0.00827006,0.02960614,-0.08571211,0.021238716,-0.0021816278,0.07432023,0.00049648713,-0.032235805,-0.01535197,-0.01231761,-0.018667838,-0.04396573,-0.021574037,0.009165636,0.038405437,0.026656935,-0.006358136,-0.033138823,0.055928703,0.039301008,-0.14363176,0.021134095,0.08811104,0.06049694,0.061681442,0.009657312,0.015212562,-0.0017138838,-0.023436198,-0.0018119882,0.042568095,-0.13136739,0.06654063,0.080017574,-0.09867659,-0.080525056,-0.029042324,-0.04381573,-0.01696627,0.05480122,0.02905662,-0.10135308,0.027347613,-0.014662043,8.339455e-34,-0.013981375,-0.024039349,-0.012575995,-0.037956446,0.091347374,0.023415456,-0.04886415,-0.019796068,-0.014658299,-0.0052655647,-0.087110355,-0.05402842,-0.010360698,0.07271722,0.04658659,0.047863916,0.02576926,-0.040983565,0.05649583,-0.014983566,-0.03588549,0.009119835,-0.059343766,0.0188782,0.08001781,0.059314594,0.0072476557,-0.0044219103,0.010713405,-0.034617007,0.036647335,-0.018866194,-0.10314791,-0.041241027,-0.007307728,0.015912807,-0.038209267,-0.014583888,0.047943674,-0.010021579,0.009362451,0.05078337,0.03311385,-0.03427364,0.040818486,-0.025009025,0.014369597,0.06913213,0.03288416,0.06605635,0.04033612,0.01003363,0.032977898,0.054140836,-0.092516,0.038989816,-0.053061955,-0.04153497,0.044944692,0.106879294,-0.009392361,-0.015093317,0.027859833,-0.054868888,-0.00041137054,0.016398337,-0.017596358,-0.038579985,-0.048395563,-0.021953937,-0.06487638,-0.104159355,0.061069038,-0.002909026,-0.015804958,-0.051644415,-0.030311156,-0.008079035,0.008270963,-0.011691725,0.07470643,0.012536608,-0.0023280948,-0.018077236,-0.044574253,0.008476518,0.00088628277,0.008554762,0.035881184,0.0366328,-0.037152316,0.010234691,-0.05897222,0.032524817,0.0019621141,-1.8809706e-33,0.108896784,-0.08265378,0.04558182,-0.05347677,-0.058745623,0.01635965,0.04072982,-0.013717289,-0.027069423,-0.058509,0.067044854,-0.04959978,0.03354783,-0.018212793,-0.031947017,-0.039694443,-0.059576165,0.015231592,-0.049277615,-0.04497211,0.003832859,0.1476903,0.038932063,-0.025723081,0.061931588,-0.041238025,-0.01383788,0.03424132,0.026701385,0.09442758,-0.027431974,-0.040227108,-0.026090149,-0.03343409,-0.07873815,0.058847778,-0.04275035,0.0048757894,0.022774436,0.0838896,0.0684755,0.026975136,0.03662451,0.003819259,0.06312497,0.11284802,-0.06803413,0.031516384,-0.011314871,-0.06983857,0.035109486,0.026604658,-0.002094011,0.04632066,0.046372626,0.06006022,-0.011444717,-0.026113352,-0.042344917,-0.03882307,-0.024802314,-0.0032422857,0.09422349,-0.046900697,0.032106966,0.017484808,-0.06263109,0.051056482,0.02128476,-0.015626553,0.046591077,0.0759917,-0.041279845,0.025316287,0.024837377,-0.009936467,-0.11787566,-0.07181242,-0.04624658,-0.08006051,-0.0018249466,0.015374977,0.02023501,-0.03475542,0.0025641439,-0.021603815,0.06683677,0.14774092,-0.018543322,0.07263206,-0.031391263,-0.066095896,-0.047057092,0.10462893,0.04499256,-4.0019778e-08,-0.010357184,0.05050509,0.015639754,-0.06875339,-0.035631888,0.015727423,0.030341772,0.075115606,0.030049806,-0.029985646,-0.036205485,0.11662542,-0.05132841,0.06332633,0.0076436484,0.03729604,-0.027055543,0.03358965,-5.5080054e-05,-0.013185988,-0.06876823,-0.0015138696,-0.09492295,0.059463404,-0.01890349,-0.0055498006,0.06662615,0.079756,-0.085817486,0.0048521375,0.045858108,0.08299966,0.0147399055,-0.062158052,0.0100696515,0.0081457095,-0.07040326,-0.006165763,-0.006327321,0.03417255,-0.060386695,-0.0019845774,-0.02194822,-0.00893687,-0.036098473,0.010286233,0.061294954,0.027510522,0.0012089303,0.10168582,0.101759814,-0.027170701,-0.05615069,-0.06896805,-0.093647994,-0.043209486,-0.032107186,-0.031685974,0.0022612598,-0.06772629,0.03606057,-0.10221073,0.12657808,-0.04693894 +4.2.2.4,"Acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate, and acts slowly on hyaluronate. Formerly EC 4.2.99.6.",384,0.99999994,-0.055705134,-0.12204889,0.00911649,-0.008814792,0.009504947,0.042519156,-0.009669023,0.050961267,0.0051584993,0.040972266,0.061150398,0.07495897,-0.038023103,0.06733628,-0.06542517,0.06806972,-0.037964907,0.034709495,0.023302816,-0.05289917,0.044483397,-0.045964092,-0.01602532,-0.025058564,-0.047288463,0.02603509,0.05034166,0.039193206,-0.019944765,-0.056307685,-0.13366957,0.017833503,-0.046004523,0.0062961783,-0.04540358,0.037558846,-0.047407635,-0.07044449,-0.027303178,0.034662515,0.07857773,-0.05008813,-0.012636615,-0.006703816,0.0863098,-0.077264614,0.05293536,0.001945587,0.012354461,0.06322937,-0.009443174,-0.037729837,0.008898087,0.01988458,-0.03669254,0.018308148,-0.15763628,-0.03315243,0.08258169,0.002468821,0.008671444,0.0049135615,0.008781089,-0.0037186241,0.023529116,0.011545027,0.110704966,-0.072176084,-0.055037137,-0.0024979834,-0.050871886,0.031043662,0.017551139,0.0059225587,0.033316847,-0.009723288,-0.03842484,-0.057376336,0.041884262,-0.10127075,0.008842612,0.033232037,0.016626203,0.11828641,-0.023188377,-0.02561299,0.016895037,-0.06421589,-0.03434547,0.008458423,0.031052956,-0.013085021,-0.066196896,0.0028088954,-0.06876919,-0.009902797,-0.0687934,0.119601145,0.025351034,0.019187102,-0.040968884,0.01005617,-0.12554072,-0.05264828,0.04015829,-0.047529984,0.014362949,0.0697637,0.03799048,0.06579609,-0.034481023,-0.027667625,-5.7404537e-05,0.0115553625,-0.08141023,0.11313431,0.051334582,0.026407616,-0.042590324,0.031212121,0.0051669828,-0.00685669,-0.01223564,-0.051928148,-0.050766688,0.02060339,-0.04312423,1.3959407e-33,0.083605066,-0.003559946,0.09888866,0.035944097,-0.057814937,-0.039546277,-0.06943272,0.006696755,-0.022489784,0.03736275,-0.054602504,0.05790014,-0.010679641,0.05660329,-0.047775358,-0.017228143,0.031138316,-0.027779521,0.033084292,-0.06148816,0.05174412,0.119051374,-0.054122202,0.022478204,-0.042272475,-0.024923353,-0.036291547,0.034094002,0.06357948,0.013016987,0.03130217,-0.040247865,0.023341225,-0.0964497,0.05950087,0.011396514,-0.011526696,-0.029956577,-0.009773125,-0.04865056,0.054021064,-0.028816856,-0.041780338,-0.089223,0.034613997,-0.06487433,0.010313432,0.07331455,0.05630711,0.008769186,0.054100722,-0.014566004,0.08069723,0.013184181,-0.01985365,-0.024428027,-0.05190805,-0.06625595,0.005436343,0.07481275,0.046919692,-0.052321486,-0.06375871,-0.0098820925,0.02219503,0.0123505695,-0.008889692,0.006410158,-0.06877572,-0.036951456,-0.053426232,0.012824531,0.05295288,0.015323583,0.012556153,0.013758388,0.013878148,0.062911876,-0.0046115704,-0.057376113,-0.09539527,0.0077449493,0.016131733,0.018713422,0.018904136,0.050950482,-0.033956993,-0.030980598,0.06076337,0.020768955,-0.0043852814,-0.07763725,-0.07783865,0.01982362,-0.03173184,-2.8827985e-33,-0.0728,-0.011670681,-0.013298542,0.031839088,0.0034700432,0.066343226,0.06801893,0.10168493,0.05348428,-0.029218664,0.11546337,-0.032953296,0.05013266,-0.08841299,0.0054603545,0.08156107,-0.07033868,-0.030230457,-0.040923774,0.03568152,-0.032020573,0.09510683,0.031964853,0.061781153,0.05400366,0.043452993,0.06044108,0.0009408169,-0.010350482,0.13973406,-0.070464626,-0.09335625,-0.06329612,0.004799003,-0.069031045,0.035857342,-0.061925203,-0.04012504,-0.005934822,-0.035127547,-0.015114484,-0.0871348,0.07313836,0.08739337,0.08009172,0.064899854,-0.021060618,0.058538686,-0.04134757,0.03346724,0.033437233,0.049546745,0.0137452185,0.03144991,0.029660074,0.07550412,-0.034690674,-0.047648955,0.0059607895,0.06464148,-0.047342096,0.020247182,0.0053892676,-0.049006347,0.044223968,0.0470253,-0.014767323,-0.03317641,0.06337862,-0.04890201,0.06615762,-0.021268953,-0.0078295,-0.026580557,0.032706976,-0.028069507,-0.0040835408,-0.04119376,-0.07043212,0.007979116,-0.019334314,0.026748536,-0.0017111112,-0.030092956,-0.008654558,0.04625306,0.032637864,0.046986394,0.035972264,0.08008753,-0.010606601,0.0019306072,-0.037069116,-0.012369973,-0.073934264,-3.165675e-08,0.065529615,-0.015224495,0.10675895,-0.06815269,0.012101461,-0.01714884,0.050612688,0.089607485,-0.0254394,0.015918095,0.03723452,0.08432951,0.031727035,-0.06971414,0.021492088,0.028329,0.03657281,0.09474975,-0.08669447,-0.10291478,-0.08437916,-0.06089493,-0.004364678,0.06726573,0.021430053,-0.081736095,0.014894307,-0.01062367,-0.09869568,-0.05380976,0.093163,0.02658531,-0.048813026,-0.049215592,-0.057829645,0.08510172,-0.0036217335,-0.016039036,0.0019237748,0.037819408,-0.0239784,-0.026851928,-0.039916117,0.026052058,-0.0402842,0.032086495,0.0047949553,0.0036136925,-0.011792051,0.05395988,-0.02851686,-0.059185613,-0.06314894,-0.04906701,-0.088670395,-0.02311855,0.064391695,-0.0687772,0.09364316,-0.02288128,-0.05740634,-0.038109276,0.09585615,0.024312647 +4.2.2.5,"Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1-3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [4].",384,0.9999999,-0.08373604,-0.14585198,-0.04494495,-0.037957553,0.002550992,0.041203313,0.024126815,0.056477904,0.04078809,0.019506123,0.04449133,0.07262454,-0.021867517,0.0011902943,-0.12207839,0.015124972,-0.037121553,0.009392455,0.002620055,-0.018782033,0.08019169,-0.061874203,-0.038985766,0.010990796,-0.05409902,-0.000589858,0.048710853,0.029527625,-0.043033477,-0.011121815,-0.07319352,-0.05638331,-0.012325143,0.0114904195,-0.03085801,0.05463712,-0.063820295,-0.024432082,-0.0020113892,-0.029526824,0.005823096,0.042472627,0.01670862,0.01552793,0.077517785,-0.12106553,-0.022547396,0.007136565,0.0016035369,0.041361835,0.032392137,-0.029568493,-0.015103392,0.092431925,0.014599949,0.007437737,-0.11946509,-0.0298272,0.1028503,0.05767671,-0.00027143236,0.01644308,-0.017165018,-0.077636406,-0.03148465,0.0048582233,0.09386315,-0.054102402,-0.056025688,0.0036591343,-0.05635057,0.03153259,0.00071933976,0.019128617,0.023447497,0.07970118,-0.02624101,-0.03831341,0.02767442,-0.058766037,0.030174771,0.08679957,0.038590387,0.14549369,0.0047589964,-0.012656046,-0.015331026,0.0035441152,0.005953812,0.0016165058,0.041437842,0.024069248,-0.043651648,-0.024659157,-0.0073137935,-0.025012154,0.008208735,0.079388686,0.10527647,-0.0050371476,-0.034097053,-0.015340426,-0.04128858,-0.11193605,-0.05802335,0.015600158,0.003571447,0.076181896,0.0486461,0.06716205,-0.06943153,0.034147482,-0.040988218,-0.015266414,-0.10366096,0.10711215,0.03717496,0.011493014,-0.062252056,-0.024263965,-0.032942202,0.0050882827,0.04063025,-0.044315103,-0.00129255,-0.06291292,-0.0163042,1.9865452e-33,0.10285058,0.012640513,0.084087424,-0.011253146,0.0023624836,-0.03215867,-0.048980914,-0.0022375833,-0.00010786963,0.046495218,-0.07167943,0.050386857,-0.04325686,0.007525572,-0.05770683,0.08836881,0.06549346,-0.05055331,0.022232378,-0.08433498,-0.010165379,0.09272418,-0.014828275,-0.040755264,0.06808485,-0.038993973,-0.047529448,0.048986897,0.06932627,-0.0054598846,0.027509835,-0.036572862,-0.0015127282,-0.025075935,0.067152,-0.0028658048,-0.045207884,-0.019644698,0.023010112,-0.008359851,0.08943981,-0.030679293,0.022345796,-0.025850223,0.016228491,-0.0519467,0.02353921,0.011761112,-0.013912488,0.06295714,0.04513553,0.018663406,0.047897846,0.053388443,-0.06861118,-0.0144256,-0.095068455,-0.096051976,0.050162043,0.08428531,0.06593685,-0.017101143,-0.037200622,-0.07556527,0.023154635,0.01741251,-0.10006717,0.07828389,-0.044841982,-0.054062232,-0.0049850936,-0.093415566,-0.004432126,0.047382273,0.010349592,0.02368664,0.010646641,0.11197786,-0.02422836,-0.059001125,-0.09854957,0.028677426,-0.023439817,0.031508483,-0.0872533,0.10143676,0.022157244,-0.03878031,-0.01215883,-0.008455737,-0.03878529,-0.056463946,-0.057450134,0.03811948,-0.031603567,-4.1005813e-33,0.024469472,-0.05981889,0.047035318,-0.03618782,0.0020575416,0.0050468603,0.09929235,-0.027105132,0.008425839,-0.056715816,0.061490368,0.030675596,-0.0039427294,-0.025698718,0.0029653504,0.09279105,-0.09475059,0.0943804,-0.03485987,0.02107036,0.0045858095,0.09346719,0.05349059,-0.008362058,0.03361936,0.025579832,0.060816176,0.026655322,0.042469595,0.16049358,-0.008683801,-0.029632293,-0.04173445,-0.03407169,-0.053718373,-0.040856075,-0.025574869,-0.09516773,0.013273853,0.046734896,-0.009975676,-0.04203169,0.04022655,0.05905857,0.10415372,0.1019124,0.008262892,0.06540456,-0.014450234,0.023232717,0.05121025,0.00050293206,0.0034777198,0.025734477,0.071226224,0.092362285,0.007534576,0.03442636,-0.00023318965,-0.03383714,-0.018338108,0.002281439,-0.015994435,-0.0781993,0.03921372,0.032567814,0.021532573,-0.062439404,0.04335593,-0.060645234,-0.024216598,-0.01470954,-0.032634027,-0.050383918,-0.0008363431,-0.011104496,-0.048497926,-0.03261517,-0.02362653,0.011998046,-0.0065283584,0.03644698,0.012617114,-0.022242665,-0.011082374,0.023283608,0.031011268,0.06739011,0.03746166,0.04977696,-0.043466724,0.0049894387,-0.02609814,0.07326889,-0.018281529,-4.413504e-08,0.063582465,0.03911966,0.02345967,-0.039926026,-0.075937696,-0.052201923,0.004508037,0.01896535,-0.009548593,0.0159893,0.039343297,0.10026775,-0.035772625,-0.0492973,-0.079093605,-0.014673829,-0.0026891395,0.025466109,-0.04786202,-0.005516992,-0.08704954,-0.0050048498,-0.050334148,0.04502216,-0.006490115,-0.108105116,0.018836321,-0.009722289,-0.14834045,-0.015102668,0.07757509,0.030628195,-0.03785096,-0.107114665,0.0025118042,0.023268057,-0.037190955,-0.011384817,0.06775775,0.016586129,0.031393427,-0.042732235,-0.025133029,0.048783496,0.010033939,-0.0104631055,-0.019613652,0.078343086,-0.041293737,0.09265909,-0.03366151,-0.037982974,-0.08407694,-0.07747586,-0.02557433,-0.069701694,0.034708872,-0.012843484,0.03695406,0.0015498291,-0.081133835,-0.073894955,0.064729095,-0.04874894 +4.2.2.6,Also catalyses eliminative removal of unsaturated terminal residues from oligosaccharides of D-galacturonate.,384,0.99999994,0.005097677,-0.095293656,0.017843984,0.020183261,0.03365873,-0.006789026,0.019669246,-0.0335381,0.07362151,0.0702812,0.0027130588,0.06762199,-0.051760256,-0.012260853,-0.0685739,-0.014908607,0.0389277,0.05111175,0.0034461753,0.032496065,0.16007173,-0.052795365,0.01036085,0.0015889965,0.11797309,-0.0015928772,0.03983169,-0.06997153,-0.021651994,-0.07950492,0.012069863,-0.044846337,0.021481413,-0.056310907,-0.023568476,0.024283363,-0.020977264,-0.008763933,0.026136026,-0.043689873,0.052931547,0.03996017,0.030923048,-0.020574547,-0.03235875,-0.004386031,-0.05849341,0.026030986,-0.022423118,-0.06127196,0.027073907,-0.054741926,-0.07006403,-0.014067469,0.06872512,0.07337055,-0.007088473,-0.07071831,0.039559864,0.07842735,0.06290279,0.06997671,-0.006076839,-0.02810151,-0.030662006,-0.10240635,0.05085565,-0.02668733,-0.001179639,0.057947583,-0.028305922,-0.017655823,-0.019343369,-0.06784895,0.10412761,0.045808714,0.025835708,-0.06923908,0.038813133,0.010647434,0.058769554,0.03318062,0.03328235,0.06523188,-0.02117026,-0.004562668,0.0044330936,0.013234467,0.04106929,-0.010059026,0.021356668,-0.04521777,0.006512222,-0.041269332,-0.09147318,-0.08874311,0.06025932,0.0092057865,0.05896249,-0.014013691,0.004517703,0.0046408293,0.022554364,-0.116052136,-0.059556197,0.108257346,0.016836956,0.06311241,0.08320279,0.023963125,-0.017197939,-0.030660875,0.036910377,0.027565407,-0.14501446,0.104952246,0.04467712,-0.05331624,-0.023285586,-0.03220205,-0.0039788736,-0.042290512,0.074592836,0.046241432,-0.08688151,0.05236697,-0.0005677146,6.540259e-34,0.01513946,-0.006927763,0.020349732,-0.048605386,0.012244126,-0.009781933,-0.018333698,-0.017913226,0.077420175,-0.001019215,-0.10931972,-0.03812777,-0.010097544,0.0921382,0.0114433635,0.016731167,0.025766399,-0.07484186,0.015056749,-0.019880075,-0.023480091,0.052523118,-0.03854081,-0.0098381685,0.08152922,-0.020671183,-0.07242829,0.046605326,0.12153681,0.007628154,0.08299573,-0.028998615,-0.08684163,0.04061218,0.029317675,0.04368417,-0.028448056,-0.056398097,0.05758997,-0.038550764,0.009856628,0.011299292,-0.026886377,0.005781514,-0.029212002,-0.018488476,-0.0024900257,0.05411085,0.01028823,0.013187216,0.040624432,0.00443059,0.022371441,0.013666941,-0.053907197,0.05771365,-0.038476676,-0.040184483,0.06782528,0.058939733,-0.06334955,0.021174243,-0.009163059,0.013767565,0.019915657,0.050647367,-0.03100923,0.019240212,-0.05068707,-0.056516875,-0.075788885,-0.060363967,0.034416422,-0.033361454,-0.051448222,-0.02431638,-0.021575646,-0.0032968884,0.02629664,-0.017510135,0.07066585,0.058853082,-0.037227564,0.012262507,0.041418098,0.013228941,-0.04326755,-0.019893399,-0.010685853,0.08358567,-0.03915375,-0.03729206,-0.076143146,0.03551987,-0.035353437,-2.9173239e-33,0.07561106,-0.07975838,0.082066454,-0.015420866,-0.042513017,0.031211525,0.01786253,-0.05624084,0.024096988,-0.106657684,-0.035837274,-0.011983287,-0.014544694,-0.022465343,0.016152645,-0.02338739,-0.08502659,0.103485085,-0.090035126,0.018991884,-0.009574255,0.055852707,-0.015443784,-0.027360564,0.03604567,-0.03426775,-0.008480751,-0.0028736382,0.02512318,0.08344348,0.033226125,-0.015436923,-0.057267286,-0.09349699,-0.023723366,0.033079535,-0.036847606,-0.041987993,-0.00022181391,0.057414465,-0.035535093,0.028377002,0.019302713,0.011227655,0.06753936,0.04430905,-0.08108818,0.038002256,0.052161273,-0.015015855,0.038840096,-0.039648045,-0.030830875,0.005372519,-0.010632551,0.028564835,0.08043614,-0.0065562334,0.061773162,-0.07368664,-0.039302386,0.012419567,0.070481315,-0.12497542,0.01752419,-0.008524047,0.025434,0.062399846,0.03391968,-0.10448326,0.04906416,0.027703976,-0.018483685,0.023822512,0.03941804,0.016403636,-0.11362168,-0.03518223,-0.011072269,-0.007970524,0.08872382,0.025840247,0.039064426,-0.06293014,-0.009467475,-0.047401045,0.051004782,0.09586609,-0.045455236,0.016628126,0.00083008787,-0.046441596,0.08016074,0.09623665,0.09782611,-2.2552886e-08,0.0571086,0.015538745,-0.03763728,-0.06755868,-0.091006145,-0.01868301,-0.019093681,0.023884797,-0.014196183,-0.0654688,0.020717025,0.1028505,-0.05559253,0.034621935,-0.022964168,0.028967097,0.0028908201,0.008185164,-0.02813525,0.040262885,-0.064489834,0.010917534,-0.11105663,0.0101897,-0.02821477,-0.09971891,0.078573056,0.0636382,-0.044404883,0.0028824944,0.030023295,0.047540963,-0.018777005,-0.046032555,0.015653875,0.021512508,-0.02849761,-0.04217567,0.015254879,-0.010712176,0.008842447,0.0015268268,0.008198056,-0.031012444,-0.113616474,-0.024366451,0.0075093918,0.11690981,-0.08336497,0.1341632,-0.024484491,-0.03602596,-0.10662669,-0.06133513,-0.07876465,-0.080053546,0.0067869835,-0.007995621,-0.018710118,-0.08513373,0.04223207,-0.0024153637,0.1120483,-0.045943208 +4.2.2.8,"Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.",384,1.0,-0.041029442,-0.1277547,-0.034976806,-0.04379907,0.0017757737,-0.040207554,-0.01039002,0.006885194,0.04009342,-0.05122911,0.021540472,0.1121765,-0.026162429,0.073351696,-0.0816928,0.05457352,0.06740576,-0.020486329,-0.005676344,-0.0003387106,0.083864525,0.05546437,-0.0011909913,-0.060366172,-0.005380321,0.0066674524,0.039126832,0.05019062,0.020204492,-0.06992625,-0.050898697,0.030095728,-0.067058146,-0.016499117,0.0800077,0.02884192,-0.04592978,-0.011853417,0.031531807,0.03747333,0.008335238,0.020187221,-0.013538331,-0.028455583,0.033279907,-0.062604584,-0.021624684,0.012538872,-0.04179335,0.057710987,0.03025272,-0.0072540366,0.026557246,0.10159617,0.02025213,0.04104619,-0.19419767,-0.012310618,-0.039843194,0.06427008,-0.003629939,0.05406157,-0.0071156668,-0.04698879,0.02887815,0.017123917,0.066135265,-0.073244855,-0.04623722,-0.000246007,-0.026586773,-0.02625053,0.049215917,0.042047575,-0.004270595,0.0030543886,-0.035146423,0.019593092,0.0483802,-0.024100149,-0.038562693,0.025594065,0.051532052,0.07678841,-0.012889982,0.03243496,-0.071555905,0.047157586,0.009487547,0.003073187,-0.0446484,-0.051260892,-0.007748433,-0.072421834,0.0007547002,-0.07470546,-0.008202852,0.08869954,-0.08498543,0.012474756,-0.029849632,0.053656884,-0.0073419483,-0.045249242,-0.040897314,0.03363482,0.0575767,0.056750845,0.0065740715,-0.00704767,-0.048317794,0.023542223,0.029955331,0.008880851,-0.12383908,0.022873152,0.007865063,-0.03372207,-0.075709954,-0.06152044,0.027406678,-0.01947733,-0.022950452,0.06473437,-0.06464723,0.057646353,0.028876066,1.7738103e-33,0.08330638,-0.022655625,0.033914514,-0.094703406,0.002719618,0.030330682,-0.050101873,0.011478844,0.071000986,-0.01395202,-0.073809355,0.028419884,0.04874479,0.013064092,0.022750268,0.07697482,0.028996417,0.004880991,0.0577983,-0.0795947,0.054792155,0.13437523,-0.07950585,0.019053059,-0.09339067,0.03211943,-0.026307998,0.005036709,0.012511502,-0.022387538,0.03663658,-0.07052189,0.011747971,-0.020457791,0.00536219,0.05897694,-0.10894128,0.0010154403,0.0065546706,-0.06277097,0.049253643,0.09885292,0.012208543,-0.025519531,-0.05616182,-0.084685735,-0.02577503,0.014822732,-0.09742784,0.09004977,0.08740892,-0.012636136,0.016878562,0.010890154,-0.026252644,0.045298602,-0.057455946,-0.05247458,-0.0021610807,0.061715063,0.041526973,-0.1049421,-0.045413066,-0.09046431,-0.03566848,0.014438629,-0.04451147,0.00020981803,0.003468266,0.0017402354,-0.002732414,-0.022615079,0.03705969,0.11251547,-0.01050541,-0.07036975,-0.011527766,0.07064638,0.07045467,-0.020459905,0.041828644,-0.045323767,-0.020254709,0.038675062,-0.046485547,0.025488453,0.02153126,-0.0800526,-0.005816973,0.01950542,-0.023812283,-0.09157304,-0.063317254,-0.0021673306,0.053147774,-4.1095327e-33,0.04301409,-0.017585846,0.05898146,-0.01220785,-0.031451527,0.041735087,0.036692094,-0.040728126,0.033409696,-0.032214057,0.09832327,0.024750112,-0.06544585,0.03861687,0.024210311,0.036514692,-0.05255279,0.08817471,-0.017112046,0.021934979,0.00039360992,0.07581723,0.016583884,0.06493499,0.02356674,0.021660607,0.06678591,-0.03842391,0.010247896,0.07589501,0.019547483,-0.0074983123,-0.041255176,-0.07389827,0.03091863,0.052539587,0.029154718,0.0063661127,-0.11001699,-0.10549818,0.06915959,0.0067801815,0.009864448,0.09867644,0.042856447,0.015161364,-0.105493054,-0.021507919,-0.070182934,0.053835254,-0.0077007688,0.009238384,0.017482057,-0.041183952,0.087065965,0.045344286,0.04973182,-0.04234077,-0.078599945,-0.010287167,-0.029044477,0.07323109,-0.07614537,-0.064425714,0.06527116,-0.039119754,-0.03501462,0.05660523,0.05965176,-0.018050365,-0.048402112,-0.046465706,0.08520166,-0.048050426,-0.048279688,-0.06976305,-0.043347247,-0.064839005,-0.038832035,-0.047234513,-0.008823872,-0.029932218,0.02335436,-0.0060035284,-0.008994647,0.05504298,0.057973884,0.04277449,-0.012906353,0.09443901,0.010046425,-0.0142756915,-0.021799065,0.034035694,-0.009220349,-3.056527e-08,0.063330665,0.042030375,0.042697407,-0.03034855,-0.08566641,0.0109938895,0.025998237,0.0027250075,-0.02046347,0.01877575,0.028068477,0.106767,-0.01729639,-0.007107828,-0.04599277,-0.018692182,0.01898328,0.008839477,-0.034637887,-0.021035466,-0.17219412,-0.008197058,-0.0060513564,0.077190295,0.009662254,-0.06896392,0.015964134,0.017073045,-0.0027319707,-0.008036862,0.06419106,0.086997755,-0.03626228,-0.09623496,-0.016543316,0.01052326,0.06553046,-0.0054836087,-0.013476477,0.032920055,-0.051917497,0.048873045,0.0100220805,0.046075705,0.078368,-0.029856222,0.019149683,-0.04663825,-0.021877104,0.05082214,0.01335122,-0.010826754,-0.04298823,-0.13754755,-0.10518956,-0.06231111,-0.014628084,-0.037837353,0.051922318,-0.015860653,0.028070664,-0.075692326,0.070518516,0.033603936 +4.2.2.9,"The enzyme catalyses the eliminative cleavage of an unsaturated disaccharide from the reducing end of homogalacturonan (the backbone of smooth regions of pectate, also known as de-esterified pectin).",384,1.0,-0.038157754,-0.0045613754,-0.00891088,-0.022748543,0.0024899966,-0.004878945,0.008609458,-0.016080031,0.023262024,0.044817053,0.08169929,-0.033737447,-0.07074521,-0.008325686,-0.03997055,0.018028554,-0.033651177,0.0063003926,0.012815543,-0.04034361,0.109330416,-0.019598663,-0.07101226,0.026608264,0.03181732,-0.011701302,0.012072882,0.006892583,-0.0064239735,-0.0767693,0.02025957,-0.034237836,0.065560296,-0.014783287,0.008905375,0.066971645,-0.028632848,-0.039570313,0.050883334,-0.06610642,0.066076845,0.024616277,-0.027873361,0.0015638187,-0.02799898,-0.06549984,0.021151118,0.012305916,-0.03873557,-0.09587827,-0.027667072,-0.08734564,-0.046446174,0.021866854,0.088125125,0.0062187095,-0.05244456,-0.008999595,0.014951511,0.02295934,-0.014004909,0.04070826,-0.074729115,-0.010109207,-0.06346231,-0.057041306,0.032086357,-0.08535997,-0.0851971,0.114472665,-0.030336734,0.0013815823,-0.004952781,-0.054036517,0.061252877,0.026050668,-0.06788547,-0.07439758,-0.021365039,0.010988005,0.03409139,0.036325052,0.04415016,0.059518136,-0.018979859,-0.059853576,0.06543741,-0.015254624,0.012592772,-0.038297627,0.045578454,0.0015028791,-0.033602227,0.01983556,-0.032952536,0.0047674775,-0.013968103,-0.014896813,0.08410225,0.013012568,-0.0113544725,0.027821146,0.04496552,-0.18640594,-0.03653522,0.10903558,0.014423657,0.08462718,0.10017038,0.052495774,-0.038819566,-0.008623505,-0.011934741,0.07446487,-0.113316774,0.0853539,0.044227,-0.044021674,0.012636716,-0.015694553,0.018524285,-0.022089833,0.016953956,0.09784902,-0.085546665,-0.007558254,-0.09610377,1.26278785e-33,-0.014531717,-0.07950939,-0.014019453,-0.027192404,0.0372232,-0.037215248,-0.047109637,-0.04051873,0.040447526,-0.01867359,-0.13824153,-0.022690997,-0.024470173,0.15212089,-0.037445046,-0.07829093,-0.019656068,-0.045800027,0.031888723,0.03571277,0.0007939277,0.052318715,-0.07343578,-0.0650003,0.047143,0.013969013,-0.022090225,0.06360584,0.073514506,-0.0075693266,0.055008244,-0.07100079,-0.06431282,0.031187506,0.058414638,0.03943499,0.042897537,-0.026082197,0.0051952573,0.028727464,0.043415364,-0.008351862,0.0026909101,-0.010044616,0.027224274,-0.017229868,0.049254037,0.066378,0.008957524,0.036338553,0.060717776,-0.01993134,0.047355846,-0.013709099,-0.1061995,0.03746808,-0.019549586,0.0010942774,0.023993243,0.01646219,-0.030966498,0.0031784067,0.023578955,-0.012364383,-0.020656534,0.02446009,-0.062293094,-0.013060112,0.0092021795,-0.012115931,-0.11110505,0.00859749,-0.0051476434,-0.036744583,0.022594558,-0.0333811,-0.049311172,0.05608548,0.022520913,0.017817702,0.020252826,-0.0041020294,-0.020995848,-0.051932286,-0.04769623,0.037790876,-0.060721535,0.03159519,0.014606166,0.066087276,-0.052698456,-0.032963317,-0.0339622,0.08269495,0.067473054,-3.1854068e-33,0.081715316,-0.12465842,0.08595711,0.015776595,-0.067923896,0.051307034,0.035146467,0.01744507,0.026831266,-0.02694646,-0.0001734581,-0.006344059,0.06594693,-0.036655843,0.040644422,0.077975646,-0.084452614,0.08530096,-0.058880445,-0.013483991,-0.11237466,0.085077696,-0.0049345,-0.04545971,0.10629558,0.051492844,-0.011711454,0.07988431,0.015947433,0.032732025,-0.07143256,-0.09871868,-0.06282641,-0.06283534,-0.10247367,0.061087903,-0.040680125,-0.016897537,0.03280096,0.0127096735,0.01402675,0.017643867,0.064742364,0.05404398,0.017467078,0.0552453,-0.029924227,0.06472844,-0.015377159,0.004325299,0.016393729,0.045920324,0.04873891,0.013487626,0.033124823,0.058029927,0.07631159,0.007814986,-0.010781922,-0.046686243,-0.055432983,-0.04417674,0.07043821,-0.0005267657,0.061811272,0.011445771,-0.028008958,0.040551685,0.05297841,-0.0034668962,0.062273853,0.051418897,-0.093401745,-0.0074960045,0.019899514,0.07168359,-0.1086129,-0.047547106,-0.013956804,0.008888307,0.045998164,-0.0043290113,-0.047936216,-0.091138184,-0.012536555,-0.015263429,0.01840046,0.06593285,-0.0121648805,0.04093765,0.043995753,-0.059086703,-0.021633001,0.092926174,0.039132494,-2.9910613e-08,-0.0006636365,-0.013392855,-0.035369765,-0.042472895,-0.020114593,-0.041405648,0.06897493,0.012082914,0.025026347,-0.06451282,0.006473318,0.04171272,-0.026219439,0.05750634,0.0018739139,0.011201246,0.0036820902,0.037418317,-0.011172509,0.034007415,-0.08036636,-0.056882933,-0.108203866,0.111276984,0.01721597,-0.05488821,0.016591564,0.067360565,-0.058819726,-0.008650665,0.019412177,0.08665712,-0.07438939,-0.05507928,0.0042143743,0.08686771,-0.045189116,-0.054055203,-0.032886494,0.009881497,0.06517721,-0.019457,0.024540415,-0.054659225,-0.059470955,-0.009602163,0.042536564,0.06579663,-0.001000837,0.06589903,0.06213314,-0.007233596,-0.062135845,-0.052549023,-0.11346831,-0.04704782,0.027484037,-0.01830536,-0.020334337,-0.01255245,-0.016370963,0.012582217,0.15214111,-0.029690247 +4.2.2.10,"Favours pectin, the methyl ester, over pectate, the anion (which is the preferred substrate of EC 4.2.2.2, pectate lyase). Demethylation progressively slows its action; it can nevertheless cleave on either side of a demethylated residue if the residue at the other end of the scissile bond is methylated.",384,0.99999994,-0.022528352,-0.012597986,0.013288084,-0.06398206,0.073616624,-0.019406194,0.020460121,0.010534298,0.040230807,-0.00447545,0.10018767,-0.057320226,-0.068972185,0.041559033,0.03556847,0.022616915,-0.046921242,0.01546301,-0.0015965106,-0.007850507,0.042728323,0.01767488,-0.036111876,0.005348632,-0.02772654,-0.022028297,0.050342686,0.05053667,0.07630554,-0.12942745,-0.03633316,0.09478119,0.04403727,-0.055174153,-0.031714786,0.09255941,-0.013000233,-0.07492595,0.019950239,-0.002855887,0.06607073,-0.0011612914,0.0025355795,-0.06423293,-0.08655383,-0.0626535,0.11678103,-0.060045943,-0.008623455,-0.07582022,0.05435314,-0.081021145,-0.013615518,0.01786701,0.037461963,-0.016322803,-0.05325612,0.013268203,-0.034914106,0.01753811,-0.005781909,0.035362948,-0.05414561,-0.0008464975,-0.10064677,-0.03466697,0.13676324,-0.062010974,-0.08010101,0.045660414,-0.045206666,-0.018783167,-0.0012450928,-0.016188191,0.06752685,0.034013808,0.01829596,-0.13996036,-0.02434343,-0.049745746,-0.04546569,0.02939971,0.0072905077,-0.031907618,-0.00013319476,-0.0723908,0.03908676,-0.06576413,0.029581005,-0.01098738,0.1564021,0.063322395,-0.061139684,-0.022315018,0.0076843807,0.056728456,0.038839944,-0.028940873,0.048963126,0.015140042,0.020834446,0.088893965,-0.06718403,-0.019504916,0.03173017,0.0067055197,0.014207056,0.04838503,0.039478235,0.037549242,-0.01087564,-0.009763262,0.060378987,0.0483907,-0.14556871,0.03384576,0.016065028,0.004171309,0.017378272,-0.04024906,0.0005684166,-0.023516124,0.008628954,0.07921234,-0.036502033,-0.05234446,-0.14115469,1.4938387e-33,0.042628396,-0.029072229,0.008904494,-0.032747004,-0.018629381,-0.001000262,-0.1139883,0.016256671,-0.016451322,-0.10052752,-0.08143957,-0.019120883,-0.008212855,0.1485122,-0.010100915,-0.096753255,-0.016258158,0.01787469,-0.009491634,-0.0004520247,0.01597026,-0.0030150705,-0.072184645,-0.0362129,0.04974325,-0.008041042,0.098733,0.007788461,0.004147813,0.0030129987,-0.02276595,-0.07206005,-0.020095225,0.037915617,0.014992668,0.07278642,-0.013481757,0.018735485,0.01613204,-0.01514112,0.05371318,0.07396011,0.053325865,-0.027428424,0.001010948,0.01726895,0.042156916,0.060375586,-0.03206008,0.07301623,0.067416556,-0.0429193,-0.018019494,-0.00086077006,-0.06032187,0.030017078,-0.03382059,-0.042529814,-0.03757594,0.015908783,0.0069525964,0.022935914,0.010100841,-0.023052271,-0.0130290035,0.061340652,-0.1106958,-0.051908452,0.0007495679,-0.018942857,-0.07662036,0.04248118,0.07872722,-0.010516591,0.01597741,-0.06179106,-0.051386826,0.06299482,0.062394466,0.04826652,0.0010649706,0.011909902,-0.020019839,-0.045419827,-0.060246397,-0.023951061,0.006094227,0.07209224,0.06177111,0.039759327,-0.026787547,-0.04235706,0.020259844,0.005096346,-0.024723653,-2.5021512e-33,0.06607389,-0.10511887,0.08781418,0.031048188,-0.023337152,-0.015491661,0.05973502,0.05707466,-0.038826697,-0.10745965,0.038667392,0.043213595,0.026976699,-0.05940834,0.054950718,0.074290745,-0.060837075,0.04011154,-0.041520774,0.012535382,-0.07611072,0.030463811,0.026296603,0.03915067,0.10811497,-0.009839553,-0.008919809,-0.0030301185,-0.013620865,-0.0034806782,-0.09757277,-0.061339244,-0.106926784,-0.06140093,-0.04759815,0.026749862,-0.020340316,-0.0054615964,-0.0135990335,0.030102588,0.042010017,0.035109486,0.023780344,0.0700093,-0.018231016,0.040835567,-0.03949492,0.039268106,0.05640336,-0.0060600867,-0.0076322546,0.03128934,0.0628299,-0.0056497715,0.04386207,0.0096916,0.015540934,0.0194372,-0.028036417,0.0043258728,-0.05333524,0.014793024,0.030692546,-0.05245891,0.020091616,0.0396791,-0.037530486,-0.023399709,0.0674162,-0.033462342,0.14136833,0.0358941,-0.039804284,-0.03386563,-0.021953331,-0.01738631,-0.03224045,-0.086788565,-0.076970726,0.015205227,0.060433153,0.008607397,-0.07138448,-0.045129813,-0.11029186,-0.0055330303,0.043617923,0.03537755,-0.042733368,-0.06259133,-0.020573935,-0.04093803,0.00880852,0.1254018,0.07455819,-4.0415447e-08,-0.034225404,-0.061235074,0.032412805,-0.042421523,-0.047673613,0.02741336,0.07064482,0.04651966,0.025073681,-0.080741055,0.02738298,0.082846254,-0.020900967,0.08117351,0.02923153,0.040608075,-0.04966577,0.0113838855,-0.03243735,0.010489033,-0.07998474,-0.023263251,-0.10001793,0.06712947,-0.020734988,0.007754441,0.048776317,0.05450137,0.011349345,-0.057301708,0.033733703,0.06408189,-0.047989774,0.030722471,0.032899957,0.02024228,-0.040019687,-0.013857047,-0.035085227,0.102569,0.093809634,-0.047756605,-0.037253443,-0.010083104,0.019300159,-0.02904452,0.014189804,0.061622225,0.0133621115,0.027201068,0.10279474,0.017642247,-0.0082407165,-0.008230792,-0.045628857,-0.0440135,0.001222473,-0.014090452,0.018862661,0.041208323,0.029364893,-0.0321286,0.12068729,-0.005771487 +4.2.2.11,"The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between alpha-L-guluronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products. cf. EC 4.2.2.3, mannuronate-specific alginate lyase.",384,1.0,0.017890543,-0.052806728,0.006030863,-0.00904732,0.004985564,0.041813347,-0.013390473,-0.0059096212,0.07292592,0.10245999,0.034886274,0.02244198,-0.033038925,-0.05616444,-0.12066322,0.05201331,-0.042312,0.0037190025,-0.028758744,0.023502383,0.16011167,-0.0067652487,0.011896686,-0.0012077552,0.07171109,-0.024988135,-0.004703954,-0.10282106,-0.002376414,-0.090292245,-0.0039203595,-0.026564283,0.0008135913,-0.030330593,0.017577484,0.07221694,-0.02300739,-0.0879638,0.057951592,0.012749042,0.03627093,-0.006103625,0.015609094,0.010238221,-0.060794964,0.015065583,-0.0022054606,0.07005709,-0.014484271,-0.042393245,0.014724482,-0.104582876,-0.045958113,0.00016011107,0.04284388,-0.025352092,-0.06970774,0.015568654,-0.024081945,0.14029238,0.063145004,0.05589698,-0.009519227,-0.006066988,-0.051012762,-0.07475586,0.09610591,-0.057746593,-0.035535883,0.056763098,-0.045181252,-0.0190949,-0.007844629,0.009638697,0.07964619,0.03843877,0.040055018,-0.111447886,-0.03430786,0.04039958,0.01767501,0.013930992,0.08718083,0.028216828,0.031526443,-0.07902047,0.01421287,-0.0006397647,0.08394755,0.0029183812,-0.021834886,-0.015046343,-0.011510376,-0.020783069,-0.047723237,-0.022117374,0.004515586,0.052973244,0.028592715,-0.0014595245,-0.018424772,0.058275975,0.02851109,-0.1398779,0.02432645,0.09174113,0.0610166,0.06150936,0.012702625,0.022141427,0.0039935745,-0.024808705,0.0022372769,0.031801455,-0.12949108,0.069495134,0.07742669,-0.10507174,-0.07447145,-0.022478832,-0.041854154,-0.014756438,0.059300028,0.031982884,-0.1073281,0.030960597,-0.028444463,9.53156e-34,-0.012608979,-0.009479054,-0.0027508007,-0.03323644,0.084638305,0.031586185,-0.050926458,-0.021954998,-0.030346375,-0.0022478644,-0.08882778,-0.045635674,-0.009859586,0.07200895,0.04992115,0.033425312,0.019441914,-0.03951216,0.04342065,-0.008260999,-0.033162568,0.009297957,-0.06124423,0.027019566,0.08244453,0.055252355,0.007913608,-0.009112648,0.012112755,-0.03150316,0.04840196,-0.015436232,-0.110142134,-0.040305343,-0.0049216994,0.015740389,-0.049020503,-0.014061891,0.044766523,0.0068620495,0.010963949,0.06221723,0.025847925,-0.034851983,0.04880489,-0.030661285,0.014313339,0.07671871,0.027315253,0.05338752,0.042885773,0.013604941,0.03499815,0.060750883,-0.08843955,0.040928893,-0.051927164,-0.039238147,0.048163168,0.113188535,-0.0028937631,-0.0013529424,0.026916292,-0.05488529,0.0018764617,0.028015843,-0.008776595,-0.038232572,-0.046026472,-0.016552247,-0.0665963,-0.1026199,0.06612815,0.002270685,-0.012740031,-0.045002207,-0.043468695,0.0012576401,-0.0023718085,-0.009086709,0.07326332,0.009051443,0.009976455,-0.007485085,-0.040998153,-0.0046607372,0.016567172,0.0048640706,0.021393953,0.03921915,-0.023468517,-0.0016107982,-0.05433952,0.025462143,-0.017793993,-1.7938584e-33,0.113255136,-0.08096665,0.047067307,-0.04823036,-0.0628966,0.008582758,0.037584964,-0.006018348,-0.01925872,-0.06156944,0.074871965,-0.05232658,0.053020034,-0.022597305,-0.020420479,-0.04602354,-0.060029935,0.018768122,-0.042346474,-0.040331617,0.0095892465,0.14847513,0.029236464,-0.01706558,0.06353817,-0.042038303,-0.011000184,0.03961634,0.026184782,0.08672872,-0.041139986,-0.050490547,-0.019118516,-0.04899315,-0.07883394,0.057542663,-0.04456534,0.009236433,0.026538443,0.08226855,0.067555636,0.021912372,0.047091924,-0.0022852167,0.057207502,0.101691335,-0.07780837,0.03228379,-0.016785497,-0.062382553,0.02770554,0.008720873,-0.009987908,0.042350557,0.038271673,0.046281036,-0.017380858,-0.025371151,-0.046334077,-0.03195042,-0.030434724,-0.0047613983,0.09581456,-0.040290993,0.026146675,0.023600318,-0.058760613,0.047537368,0.022241209,-0.022745982,0.04118812,0.071932584,-0.023499327,0.02521609,0.029328343,0.0016713301,-0.12937582,-0.080542326,-0.04337985,-0.08833236,-0.012117991,0.007845131,0.028601658,-0.035707038,0.011403843,-0.018376505,0.07557315,0.15187477,-0.021315333,0.07445209,-0.030127427,-0.06618596,-0.04350716,0.09814233,0.046699267,-4.015823e-08,-0.0069898753,0.038899507,0.016490318,-0.06596094,-0.03567071,0.020666527,0.027843993,0.062514134,0.023945041,-0.027060412,-0.018075531,0.11395923,-0.045805957,0.05551812,0.006797903,0.031068973,-0.027631348,0.03706552,-0.0065139527,-0.02554091,-0.08079275,0.0072276406,-0.08567032,0.054044373,-0.004800087,-0.014219131,0.057711318,0.079785556,-0.088821076,0.0016499092,0.046504516,0.07804132,0.023578987,-0.061781477,-0.0041455193,0.0069227703,-0.086799026,-0.01700814,-0.0113534415,0.03352283,-0.047235142,-0.00987624,-0.020794949,-0.010817053,-0.02896506,0.01433975,0.0650291,0.029065266,-0.0034142016,0.09348099,0.0935605,-0.02288697,-0.051052194,-0.07005291,-0.08416974,-0.050124906,-0.041424908,-0.025833651,0.0059891646,-0.071148805,0.033329472,-0.09965372,0.13426341,-0.046043336 +4.2.2.13,"The enzyme catalyses the sequential degradation of (1->4)-alpha-D-glucans from the non-reducing end with the release of 1,5-anhydro-D-fructose. Thus, for an alpha-glucan containing n (1->4)-linked glucose units, the final products are 1 glucose plus (n-1) 1,5-anhydro-D-fructose. Maltose, maltosaccharides and amylose are all completely degraded. It does not degrade (1->6)-alpha-glucosidic bonds and thus the degradation of a branched glucan, such as amylopectin or glycogen, will result in the formation of 1,5-anhydro-D-fructose plus a limit dextrin. Other enzymes involved in the anhydrofructose pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.1.111 (1,5-anhydro-D-fructose dehydratase) and EC 5.3.2.7 (ascopyrone tautomerase). ",384,0.99999994,-0.029680412,-0.08367272,-0.019611541,0.027168581,0.02114236,-0.019032674,-0.03838834,-0.0002257899,0.07383465,-0.0033787864,-0.046916045,0.12490231,-0.052076746,0.009804416,-0.101536654,0.006047525,-0.081419334,0.016066648,-0.042560168,-0.0032477118,0.09361431,-0.06037033,-0.01948868,0.015045342,0.03247504,-0.02007589,0.00346342,-0.058780544,-0.05579758,-0.09719517,-0.029763093,-0.08101228,0.046788253,0.05850151,0.011390195,0.11153843,0.00016906098,-0.035378907,-0.045257647,-0.022708021,0.012821185,-0.0064597256,-0.0022117826,0.021643182,-0.042609736,-0.08763029,-0.11577524,-0.02268811,0.0005781023,0.062104035,0.0025183691,-0.044772252,-0.03511453,0.046511196,0.06560927,0.0054367967,-0.075918645,0.018111806,-0.01589943,0.07499136,0.00657016,0.043316998,-0.07650908,-0.03828844,-0.049796015,-0.052683752,0.04565431,-0.08458661,-0.082772054,0.042488933,-0.062183563,-0.055457372,0.022552967,-0.004858674,0.06260143,0.04581516,-0.027082562,-0.021186624,0.0063674697,-0.0076753786,0.08646501,0.029730266,0.096859194,0.04013545,-0.031646412,-0.07072837,0.039569836,0.008388952,0.0524042,0.057145618,0.016156428,0.0038712337,-0.007537547,-0.027332127,0.043137792,0.057206098,-0.0100265695,-0.045056242,0.061993334,-0.04204919,-0.01109756,0.033909827,0.04333615,-0.0454525,-0.057587422,0.062193837,-0.03523509,0.07688428,0.0735266,0.011660763,0.0120192235,-0.005268812,0.012113741,0.020774748,-0.07555471,0.06766056,-0.015828932,-0.038130894,-0.00036255433,-0.034141034,0.0066210255,0.05857487,0.10558726,0.04738905,-0.026419919,0.0860138,-0.08128846,7.855006e-34,0.07390658,-0.044002593,-0.041121252,-0.002681263,-0.028628869,-0.0038149257,-0.06154137,0.052854083,0.011166979,0.008775282,-0.070761256,0.002267211,-0.00436054,0.032890458,0.01531541,0.02961758,0.08145291,-0.076342314,0.035714123,0.043592017,-0.025008686,0.062217873,-0.012715111,-0.01204195,0.05896334,0.06096426,-0.07643581,0.062167156,-0.0040070144,-0.03325242,-0.014112113,-0.017634118,-0.07001046,0.057484593,0.08229891,0.0721427,-0.028902134,0.07387702,0.075406104,0.06510285,0.025964376,0.015513223,0.0070318244,-0.03198674,0.06594906,0.004539475,0.016478788,0.03331472,-0.023376068,0.06970349,0.0667705,0.00070655777,-0.032567963,0.038796026,-0.100973524,0.054441072,-0.022714954,-0.0151677765,0.02748505,0.06264024,0.016593903,0.045015164,0.017975483,-0.050842434,-0.009165169,-0.004417533,-0.038026154,-0.031235013,-0.0836727,0.0054604704,-0.069658354,-0.029822256,0.078194566,-0.028906789,0.037378747,-0.018732596,0.001872514,0.04493892,0.00986923,-0.036306456,-0.0076422105,0.019029435,0.026781209,0.029759668,-0.076459765,0.0536889,-0.0078189075,-0.040887617,-0.033560228,0.02074633,-0.043878894,-0.040137716,-0.011548805,0.009494681,0.017082097,-2.5956201e-33,0.12501685,-0.11631285,0.0499787,-0.036399905,-0.060353145,0.053505816,0.058833033,-0.058621474,0.004180095,-0.060833097,0.03678691,0.058214158,0.00095367356,-0.050557572,0.02548795,0.017884756,-0.08630348,0.077359356,-0.06411823,-0.0055376994,-0.015734103,0.15852924,-0.0204015,0.0031877612,0.07879512,-0.02396121,0.06417055,0.039761666,0.08394327,-0.002878578,0.03443857,-0.023646828,0.024743516,-0.0406323,-0.024446175,0.039521296,-0.035240583,-0.05553401,-0.037162323,0.023958147,0.07996381,0.062702045,0.046706337,-0.0056192894,0.07710987,0.05617509,-0.09108536,0.0027552836,0.00700981,0.00027208112,0.013688321,-0.04217176,-0.057343293,0.053207707,-0.0009654085,0.04023323,0.052347537,0.018763559,-0.031069456,-0.016918365,-0.08088457,-0.022390977,0.079284556,-0.03869415,0.06580532,-0.009046666,0.027074834,0.05511385,-0.0051595788,0.05243526,0.03810991,0.02109702,-0.010769488,0.015874894,0.023511916,-0.016789837,-0.09419402,-0.06406823,0.0071934923,-0.0319095,-0.0038339165,0.081086144,-0.030662643,-0.039025,0.045162924,-0.08705524,0.049839277,0.09873023,0.025277259,0.054530893,0.03480268,-0.054834392,-0.030412914,0.0098233735,0.007241361,-4.6033943e-08,0.033897802,0.007071471,-0.064487964,-0.034503255,0.03975705,-0.027368473,0.0091578625,0.07701521,0.006832148,-0.038607348,-0.050938036,0.11951725,-0.03727373,0.0126123475,-0.06975772,-0.008692985,-0.037152648,-0.0095340805,0.0077662286,0.028570285,-0.17498693,0.0013219786,-0.14045835,0.016053284,-0.018607814,-0.10617315,0.047810216,0.024956733,-0.02702166,-0.011855573,0.008946114,0.06637905,0.04081535,-0.09167032,-0.013643267,-0.037190598,-0.01422585,-0.028498577,0.03053748,0.060650337,0.011678635,-0.016198268,0.022272015,-0.0122569585,-0.061948296,-0.039942816,-0.02886056,-0.055053063,-0.009150027,0.11541649,0.03547808,0.04914732,-0.10176246,-0.061862502,-0.04142987,-0.10252356,-0.013469772,-0.04904908,0.014144677,-0.08813661,-0.025530782,-0.041689623,0.15114205,-0.020735206 +4.2.2.15,Also acts on N-glycolylneuraminate glycosides. cf. EC 3.2.1.18 (exo-alpha-sialidase) and EC 3.2.1.129 (endo-alpha-sialidase).,384,1.0,-0.02258861,-0.090441786,-0.101404764,-0.01354857,0.06491609,-0.02079869,-0.008025798,0.031175483,0.03525795,-0.018328218,0.06268117,0.035450034,-0.11804796,0.057341788,-0.015333054,0.016361648,-0.0011763531,-0.033209667,0.018123103,0.0077713714,0.04130856,0.018493617,-0.012142804,-0.0013912839,-0.044333823,-0.009979629,-0.016827108,-0.022718422,0.035976898,-0.11259278,-0.01197838,-0.010641399,0.04463438,-0.06947143,0.030650418,0.00949279,-0.08629709,-0.036003057,-0.008095251,0.013538443,0.035417277,-0.06361169,0.012045583,-0.019585963,0.020523136,-0.067165315,-0.023522234,0.04872322,0.024191031,0.044048972,-0.0037225033,-0.113344595,-0.02647782,0.020048946,-0.03108032,-0.0015055612,-0.14888307,0.0040359558,0.03034896,0.1064161,0.045902114,0.0554197,0.0003750485,-0.0029966258,-0.05904797,0.030513685,0.12948284,-0.073280394,-0.035020158,-0.014640311,-0.024994591,-0.0523544,-0.011795482,-0.022538176,0.0024432398,0.13178295,-0.005881641,0.011484557,0.00703654,-0.08458756,0.004818614,0.007343724,0.08382521,0.053309914,0.03434127,0.0110783875,-0.055609815,0.029046798,0.037296385,0.0030286473,0.06625041,-0.06694823,0.01325571,0.025701797,-0.0009275722,0.010200486,-0.022454934,0.018299058,0.012387366,-0.038847927,-0.039957955,0.0015273873,-0.05380818,-0.017518867,-0.058803696,0.12326082,0.054937255,0.028836288,0.008705283,0.0012045277,-0.09641125,-0.007937485,0.04682638,-0.06818705,-0.087259255,0.014914783,0.05016333,-0.0018135974,-0.052163616,-0.05786009,0.047353745,-0.0073125707,0.027839748,-0.0022874163,-0.021821445,0.13218862,-0.01646778,-1.324531e-34,0.08496633,0.0052181734,0.046859525,-0.041985154,0.080939405,-0.023212688,-0.06514733,-0.06403786,-0.058007747,-0.03534271,-0.052483648,-0.030099064,0.03483479,0.09409609,0.021474622,0.08548338,0.064108826,-0.010087582,0.030279677,-0.04059373,0.08840108,0.06540926,-0.04846911,-0.058042962,0.013634408,0.07114446,-0.04301117,0.056166932,-0.008760474,-0.021166872,0.0054183146,-0.07876064,-0.087336324,0.065256014,0.055364624,0.044405714,-0.053338315,-0.015968464,0.035871718,0.0015782752,0.030577086,0.108948424,-0.018688936,-0.0064283977,0.012487212,-0.041824296,-0.04116608,0.066107996,0.09402373,0.027518969,0.046862558,-0.04634676,-0.029194247,0.049393695,-5.2197913e-05,0.029380651,0.025132133,0.013881166,0.0071757077,0.024451341,-0.028059475,0.03307818,0.0028956996,-0.0798354,-0.012149346,0.046033073,-0.10803304,0.01828987,-0.059340958,-0.044710197,-0.057371758,0.003631413,0.09577893,0.022615472,-0.004858712,-0.066483736,-0.026703535,-0.015619425,0.013161115,0.0021453833,0.016437912,-0.025751144,0.034452185,0.009903493,-0.09312582,0.049198236,-0.01826145,-0.08326363,-0.0020796359,0.022325493,0.06622622,-0.06472191,-0.042810816,0.058547992,-0.086456604,-1.7160302e-33,0.056569442,-0.031070828,0.04545554,-0.014414492,-0.030421518,0.04022687,-0.010435352,0.004909702,0.054537676,-0.024146955,0.036232244,0.007612059,0.017639464,-0.04281781,0.006591375,0.013341736,0.038808968,0.066795036,-0.0025631413,-0.111319445,-0.01763215,0.0051966803,0.012800661,0.01089231,0.1018974,-0.008328366,0.05885489,0.0020047217,-0.03915485,0.039615974,-0.029584842,-0.009386102,-0.08515836,-0.059824537,0.052604366,0.019154137,-0.0154366605,-0.0010331499,0.00044730754,-0.066168316,0.020345245,0.044816326,0.11254414,0.113072544,0.069044806,0.11989576,-0.054391596,-0.039270412,-0.08947144,-0.024787655,0.018954435,-0.0032353972,-0.0071176644,0.09188955,0.06780768,0.042888366,0.07936236,0.02148141,-0.074386984,-0.037558522,0.017181315,-0.007038275,-0.04073403,-0.08411388,0.12110554,0.0002445728,-0.055734057,0.042828478,0.08933818,-0.018862518,0.034792088,-0.08662922,-0.043398526,0.048488583,-0.031662922,-0.034280676,-0.04450981,-0.09487567,0.026082331,-0.022297222,0.0051830974,0.012833263,0.00967789,0.01748044,0.02003193,-0.016647112,0.040635552,0.11888061,0.04671645,0.06043841,-0.026238538,0.010442118,-0.03960393,0.05195766,0.061440576,-3.5606003e-08,0.08738952,-0.0723233,-0.026007907,-0.06965191,-0.07162331,-0.03080936,0.015632944,0.069004074,-0.0068541043,0.010405152,0.012766699,0.09296516,0.031412195,-0.03555729,-0.00549266,-0.008120003,0.03404529,0.047539156,-0.044056997,0.00050128903,-0.10511396,-0.001774833,-0.05418228,-0.023364356,-0.024348829,-0.113572076,0.059338015,0.0070560994,-0.020476848,-0.012194536,-0.038913913,-0.01918671,0.004836101,-0.0613231,-0.0050882157,0.053706344,-0.011695695,-0.011955885,0.03557201,0.011047806,-0.018818507,-0.048116524,-0.006053512,0.025507124,0.0002935685,0.006552774,-0.01718006,0.029257238,-0.035795618,-0.028003529,0.019166466,-0.06023262,-0.028647747,-0.058342706,-0.1883106,-0.0323288,-0.03161666,0.0369261,0.105947025,-0.08508718,-0.016344246,-0.016163796,0.09534705,0.0492738 +4.2.2.16,"This enzyme, like EC 4.2.2.17 [inulin fructotransferase (DFA-I-forming)] and EC 4.2.2.18 [inulin fructotransferase (DFA-III-forming)] eliminates the fructan chain from the terminal disaccharide leaving a difructose dianhydride. These enzymes have long been known as fructotransferases, so this is retained in the accepted name. Since the transfer is intramolecular, the reaction is an elimination and, hence, the enzyme is a lyase, belonging in EC 4.",384,1.0,-0.03545103,0.0091331145,-0.07172655,-0.018888682,0.112463355,-0.020746237,-0.0690853,0.057830427,0.04432541,-0.016850837,0.055950407,-0.039267674,-0.042944532,-0.004597447,-0.013991686,0.026754785,-0.087596394,-0.021247104,-0.034353685,-0.09393903,0.01878526,0.036957532,-0.039531283,0.008305967,0.015115695,-0.061959162,0.015046186,-0.035758566,0.010041741,-0.10726511,-0.027216863,-0.0075988565,0.027200347,-0.06326597,-0.020138929,0.07135612,-0.0020672684,-0.07160885,0.0147931995,0.0073495405,0.018996485,0.021521118,0.05663619,-0.07751554,-0.02507996,-0.020090066,-0.029460285,0.019860204,0.050917927,0.0012395487,0.015944785,-0.05835149,0.013408473,0.08554716,0.026139775,-0.0052442765,-0.042391155,-0.032478955,0.0078654075,0.10628404,0.01953166,0.075120844,-0.017199652,-0.022041298,-0.030610036,-0.036938686,0.024590913,-0.0925481,0.0015812657,-0.04538481,-0.075439304,-0.081932314,-0.016550012,0.070570484,0.07494451,-0.027842183,-0.032043297,9.202461e-05,0.016023457,0.07045034,0.065473236,0.03229351,0.003437344,-0.035170283,-0.017723925,-0.040738452,-0.0028095013,-0.052272614,0.059635397,0.00011861904,-0.00255438,-0.05303324,-0.04731499,0.027575046,-0.10226015,0.015521535,0.005793595,0.091256544,0.050463986,0.011033624,0.024311116,-0.023972185,-0.08289975,-0.029357089,-0.1001923,-0.013393629,0.05147173,0.09156756,-0.018233918,-0.017287347,0.05231423,-0.06237177,0.056489363,0.043322958,-0.08289999,0.062478513,-0.00063949235,-0.08779591,-0.0050044614,-0.024043296,0.058964834,0.04098156,0.15777163,0.05928788,-0.04785927,0.048112657,-0.09808406,2.1791661e-33,0.03427632,0.02045299,0.046733204,-0.0060180216,-0.0062438995,-0.035294354,-0.08339086,0.04624484,0.020225322,-0.07163307,-0.090360925,-0.067712046,0.009869747,-0.0057798796,-0.061429538,-0.0480231,0.048134178,-0.068373136,0.027708208,0.03787004,0.06616891,0.08210686,-0.008261401,0.010767184,0.05416431,0.06183877,-0.01726848,0.010611969,0.076278776,0.033945914,-0.015310624,-0.12919839,-0.06430129,-0.010350653,0.011781304,0.016416395,-0.012676565,-0.028319884,-0.013219103,0.040822163,0.0071562454,0.028316192,-0.033000614,-0.09515678,0.026387539,0.010803884,0.019510316,0.045799296,0.02743441,0.08878368,0.029340321,-0.055618703,0.07282573,-0.042899042,-0.11045163,0.025784666,-0.036908392,-0.051098708,0.021749947,0.07556528,-0.02637577,0.066116996,-0.04327749,0.029149387,-0.033604138,-0.012992245,-0.04812657,-0.054835204,-0.043780375,-0.0022310256,-0.10030591,-0.052670818,0.08494108,0.024129365,0.12430749,-0.110190816,-0.093126856,0.041574582,-0.014967898,0.015864246,-0.013234655,0.04796891,0.018111657,-0.0062629697,-0.0019691158,-0.017271826,-0.023824826,-0.03518972,0.014073913,0.030139444,-0.038090277,-0.02336348,-0.01424833,0.086089276,0.09696863,-4.612389e-33,0.09202792,-0.078464545,0.057244074,-0.08378991,-0.00059433986,0.06774048,0.07013229,0.04872878,0.062889285,-0.031527698,0.06309924,-0.016711792,-0.020480994,-0.043437812,0.093466654,-0.0028981054,-0.06770092,0.015962064,-0.07417241,0.005410083,-0.029583335,0.03612244,-0.0076541197,-0.01763455,0.058329634,-0.0008708926,0.029457029,0.04404915,0.06595204,0.029601214,-0.07654712,-0.015932487,-0.02196065,-0.00026323096,-0.08350167,-0.019861823,-0.04272184,-0.029509543,-0.035781767,0.023582866,0.0009502189,0.07689684,0.019132819,0.0537307,-0.029537356,0.07129739,-0.06991939,0.063419856,0.03375723,-0.029801533,0.0055163098,0.005161821,-0.011341919,-6.484326e-05,-0.015386922,0.024414523,0.07257875,0.08683153,-0.0015346095,0.007199996,-0.04512329,-0.12178195,0.02777179,-0.014792203,0.094283566,-0.01204797,-0.039353736,0.04314222,0.052624006,-0.01445165,0.06774886,-0.017675016,-0.038383294,-0.0006652246,0.0031687699,-0.02264411,-0.09928692,-0.08530141,0.0005648069,0.009859161,-0.02628834,-0.054587208,0.0069867033,-0.0135094775,0.047510475,-0.10937723,0.028221695,0.08927083,-0.015849749,0.02455542,-0.0020818198,-0.010999057,-0.0040877033,0.07607413,0.05602613,-4.353711e-08,0.009461781,-0.06607438,-0.041244447,-0.026250938,-0.027490363,0.020165112,0.0006830032,0.05856432,0.021062925,-0.01126816,-0.010596906,0.13009527,-0.022864275,-0.0049299146,0.004014342,0.03163024,-0.0005735396,0.088443376,0.0028975208,0.06422422,-0.05148619,-0.047672737,-0.13285641,0.015007617,-0.02306007,-0.026928117,0.07454558,0.08703613,-0.012253773,-0.035418205,-0.019860895,0.04199109,-0.02083164,0.006049966,-0.09673942,0.0038652567,-0.03497131,-0.01868211,-0.02980876,0.027557153,0.045466,0.03366829,-0.059064217,-0.013858081,-0.022153458,0.009240963,-0.0030309455,0.061833628,-0.0152959125,0.041066453,0.0012077207,-0.058061585,-0.0065566446,-0.014881563,-0.03968019,-0.046296168,-0.029480206,-0.04521856,-0.01222937,-0.051564958,0.057200603,0.029154852,0.21677512,0.025450971 +4.2.2.17,"This enzyme, like EC 4.2.2.16 [levan fructotransferase (DFA-IV-forming)] and EC 4.2.2.18 [inulin fructotransferase (DFA-III-forming)] eliminates the fructan chain from the terminal disaccharide leaving a difructose dianhydride. These enzymes have long been known as fructotransferases, so this is retained in the accepted name. Since the transfer is intramolecular, the reaction is an elimination and, hence, the enzyme is a lyase, belonging in EC 4.",384,1.0,-0.04318753,0.012910107,-0.07651931,-0.04167648,0.11075627,-0.023941457,-0.081817165,0.049244158,0.04898933,-0.020814523,0.07041982,-0.03910814,-0.038810663,-0.012208859,-0.018026326,0.033417486,-0.09900249,-0.014762083,-0.04742301,-0.08378657,0.0059510646,0.03758013,-0.029444478,0.021695137,0.012260682,-0.06091253,0.023811027,-0.04019648,0.008120043,-0.0957386,-0.0029970317,0.0030967435,0.02045018,-0.052599113,-0.028799286,0.07736963,0.001773947,-0.08186101,0.006988043,-0.00013242732,0.011621752,0.00925093,0.048976336,-0.09570633,-0.011974988,-0.02655944,-0.036074985,0.011744492,0.059250567,-0.013012263,0.01719344,-0.06494364,0.022979101,0.08083631,0.029074248,-0.0064593772,-0.059146717,-0.040060878,0.006627194,0.11808378,0.01183021,0.09250956,-0.020231435,-0.022765491,-0.029218549,-0.023837028,0.020950776,-0.105646305,0.00054582907,-0.04385281,-0.07628792,-0.07936141,-0.016393123,0.05293417,0.058776457,-0.027886719,-0.031016802,-0.0027385023,0.009952716,0.062379904,0.059883095,0.033373054,0.016665604,-0.021377258,-0.03523412,-0.037179373,0.006544246,-0.056382567,0.062076386,0.022286398,0.0016371217,-0.051711023,-0.035029404,0.026212692,-0.09553244,0.013942454,0.013804418,0.08145937,0.0644889,0.017761238,0.01806171,-0.012981189,-0.07817817,-0.038964253,-0.11625712,-0.0121739125,0.060476217,0.084137484,-0.017759796,-0.026315032,0.0792627,-0.059470497,0.053399876,0.046282213,-0.09677332,0.053604003,-0.0035975748,-0.09548654,-0.0069974298,-0.013468323,0.049072485,0.039959714,0.15095381,0.052756656,-0.036636442,0.039140847,-0.1029432,1.9807519e-33,0.0482361,0.025212627,0.046396013,-0.01416007,0.0025336067,-0.029411346,-0.08003312,0.046007387,0.01928892,-0.08576549,-0.09682487,-0.060067263,-0.0065220096,-0.0045414795,-0.052781884,-0.04665266,0.041081663,-0.064172246,0.027715128,0.040203083,0.058007106,0.079071775,0.0012458399,-0.008387885,0.05495059,0.05561292,-0.028772367,0.013472009,0.06821362,0.035169546,-0.0053065033,-0.117868006,-0.055854145,0.009967817,0.020518335,0.034907985,-0.013685638,-0.030916885,-0.013671992,0.049398173,0.024529215,0.032813173,-0.038381383,-0.0812176,0.020534564,0.015309803,0.030409427,0.045940176,0.041164674,0.09081932,0.026785122,-0.043055568,0.05440762,-0.06239618,-0.103311926,0.024246097,-0.04193946,-0.05067257,0.0283892,0.07414688,-0.035620507,0.07205466,-0.031439442,0.022023598,-0.032636236,-0.03280474,-0.040504094,-0.061888035,-0.043104924,-0.015817143,-0.09223492,-0.04675687,0.08962597,0.0336246,0.13450602,-0.1072384,-0.08082843,0.03362645,-0.003892203,0.01894316,-0.0063803373,0.051247228,0.016324505,-0.018002536,-0.008351425,-0.0010624191,-0.026696568,-0.044815432,0.008338064,0.034236968,-0.055759355,-0.02881434,-0.015475521,0.07040568,0.10256172,-4.5704613e-33,0.09399901,-0.0918949,0.051106777,-0.079679705,0.0015864999,0.06851727,0.0699405,0.049440905,0.07038974,-0.020988278,0.07611028,-0.017731875,-0.0001595167,-0.04136512,0.0946356,-0.012483552,-0.070367545,0.021476896,-0.07767025,0.008130876,-0.027135482,0.039799985,-0.007830526,-0.015460252,0.069097176,0.0027146884,0.01665266,0.051296324,0.060500495,0.021157043,-0.06737559,-0.021272337,-0.019237278,-0.012127117,-0.08143646,-0.011578236,-0.039264012,-0.02878851,-0.025098976,0.027556268,-0.003746118,0.06721114,0.029002996,0.033591628,-0.03330877,0.07322068,-0.06911362,0.048155423,0.040231828,-0.032433573,0.008846173,0.007193235,-0.0149151115,0.0058877505,-0.0018390141,0.03073904,0.06519413,0.087007895,-0.014639178,6.716113e-05,-0.036396913,-0.13023134,0.035312414,-0.0025975702,0.088143595,-0.012346771,-0.03404741,0.03413608,0.062582895,-0.021205466,0.06513028,-0.015440431,-0.024397288,-0.0019904566,-0.011245895,-0.02367371,-0.0993361,-0.101119876,0.006419721,-0.00096682616,-0.014893463,-0.04710417,-0.00028447458,-0.022225207,0.039231323,-0.105610296,0.039748497,0.0826369,-0.031071417,0.022844046,0.00733596,-0.00482908,-0.012177362,0.06670677,0.050469056,-4.30773e-08,0.0064903405,-0.064854525,-0.046052177,-0.022120724,-0.024008635,0.020190956,0.011558185,0.048148144,0.020072965,-0.019143388,-0.0003301817,0.12770295,-0.02822828,-0.01884108,0.0067317416,0.01960334,0.00089884596,0.09224079,0.0024580117,0.061288185,-0.042193193,-0.037263546,-0.12618291,0.005924229,-0.02184371,-0.025105014,0.067182176,0.08880066,-0.014364105,-0.042490333,-0.013999878,0.040303405,-0.004487778,-0.007284856,-0.093339264,-0.003654829,-0.037167843,-0.022632279,-0.02548428,0.02494926,0.046697572,0.036241688,-0.056460947,-0.016056774,-0.028444614,0.004945573,0.008835927,0.07077105,-0.025512436,0.048494842,0.018165806,-0.060929984,0.0047234376,-0.015088885,-0.027215717,-0.042235877,-0.024484769,-0.052898042,-0.020606924,-0.0602679,0.05398587,0.03340858,0.20772327,0.026054008 +4.2.2.18,"This enzyme, like EC 4.2.2.16 [levan fructotransferase (DFA-IV-forming)] and EC 4.2.2.17 [inulin fructotransferase (DFA-I-forming)] eliminates the fructan chain from the terminal disaccharide leaving a difructose dianhydride. These enzymes have long been known as fructotransferases, so this is retained in the accepted name. Since the transfer is intramolecular, the reaction is an elimination and, hence, the enzyme is a lyase, belonging in EC 4.",384,1.0,-0.04092654,0.016915187,-0.0743544,-0.040332593,0.113765635,-0.027167907,-0.07342223,0.05071874,0.045641143,-0.018259762,0.06863882,-0.039842825,-0.03623416,-0.008863886,-0.022098083,0.036735527,-0.0940919,-0.017990856,-0.044378422,-0.08113821,0.0036641762,0.0404631,-0.034589358,0.019306691,0.010562718,-0.056828905,0.023585103,-0.03793702,0.009483597,-0.10003013,-0.003958838,0.0004821702,0.020087995,-0.051884748,-0.030674987,0.078083664,0.0027524834,-0.08415979,0.007686906,-0.00013643244,0.014345577,0.010367313,0.050665963,-0.094962604,-0.012324989,-0.024941567,-0.037414685,0.010162466,0.054399822,-0.013252124,0.01702957,-0.059684377,0.02195706,0.08274886,0.027613327,-0.007288431,-0.061603565,-0.040653154,0.004065216,0.119805485,0.015225773,0.08711205,-0.02326061,-0.020595782,-0.03136495,-0.02343035,0.020898566,-0.1022099,0.0018048359,-0.048318874,-0.07087265,-0.0776782,-0.017966298,0.056697115,0.060827654,-0.0307115,-0.030211454,-0.0033576677,0.012196699,0.06653264,0.05893538,0.03362991,0.01585676,-0.027176287,-0.0324129,-0.03855377,0.012839103,-0.05405693,0.06363133,0.023796905,0.0043403143,-0.053458184,-0.03504058,0.02578447,-0.096100986,0.011328313,0.014645333,0.08293738,0.06345306,0.018219167,0.016436119,-0.013457401,-0.07979278,-0.04189592,-0.12059652,-0.011930904,0.06031892,0.08300009,-0.017176425,-0.027599983,0.076310374,-0.059796125,0.054250374,0.04730408,-0.094683126,0.0535848,-0.0015341307,-0.09273382,-0.008780266,-0.013444604,0.04716603,0.040216777,0.15024528,0.054942805,-0.039014615,0.038009413,-0.10509945,1.884985e-33,0.045668393,0.024286,0.048493434,-0.017026499,0.005775407,-0.032264896,-0.08251577,0.047964945,0.020084443,-0.08784646,-0.096952334,-0.06403679,-0.011121037,-0.0037401782,-0.05625917,-0.045219958,0.04017601,-0.06696284,0.029163757,0.04175215,0.057316016,0.08277962,-0.0008314969,-0.009568772,0.050653692,0.059497476,-0.029252449,0.013347552,0.068933584,0.03603462,-0.008533296,-0.114881255,-0.056036267,0.009511293,0.022178492,0.035503477,-0.012161453,-0.03288951,-0.010785353,0.045727536,0.020179313,0.032078102,-0.037210368,-0.08210774,0.022572694,0.015127758,0.030188745,0.04580941,0.0405084,0.090206124,0.023808155,-0.04784944,0.05198957,-0.062584385,-0.104426235,0.028322289,-0.04193294,-0.052894667,0.028286992,0.07750034,-0.035410117,0.07233265,-0.03423057,0.023836778,-0.031590573,-0.032666296,-0.040109932,-0.062404465,-0.04378259,-0.0178559,-0.09085136,-0.04643386,0.09139484,0.030904025,0.13612881,-0.10483979,-0.07887171,0.032211773,-0.006307153,0.019472947,-0.0049122884,0.05166939,0.01390623,-0.017353782,-0.00347144,-0.001095341,-0.025846666,-0.044774834,0.009463748,0.032960273,-0.05716137,-0.02569901,-0.015221315,0.06708233,0.10181118,-4.5357243e-33,0.09361901,-0.09651105,0.050859958,-0.07682757,0.00035380342,0.06937645,0.07205777,0.049822774,0.07178127,-0.018225554,0.07709658,-0.0212348,-0.0013098114,-0.041054223,0.091899104,-0.009454554,-0.07164403,0.021489771,-0.08033939,0.008728636,-0.03182687,0.04272993,-0.0038034958,-0.018844962,0.07226937,0.0019237722,0.017403673,0.055032954,0.06362678,0.023312384,-0.06547091,-0.024909118,-0.02454442,-0.014505817,-0.08029908,-0.008166405,-0.044362787,-0.0289745,-0.023341715,0.026145237,-0.0038421894,0.06703265,0.026414007,0.029299727,-0.03360308,0.06740661,-0.07144689,0.048702836,0.041054416,-0.03608868,0.0067348783,0.010719308,-0.01540341,0.0036978726,-0.0052678743,0.029099595,0.067698196,0.08703603,-0.011485461,-0.00219324,-0.03609341,-0.12845992,0.029093252,-0.0020264855,0.09002798,-0.015163356,-0.029708473,0.028871907,0.059351504,-0.02609379,0.06270769,-0.018581372,-0.023385545,0.0011453547,-0.008084579,-0.025679406,-0.099524274,-0.1022721,0.0057456484,-0.002298659,-0.016737927,-0.048424076,-0.00012866057,-0.026992923,0.04207162,-0.10287899,0.037974212,0.08617132,-0.025398273,0.02567321,0.008347982,0.0027024054,-0.010664237,0.06487593,0.047659356,-4.320179e-08,0.0064197937,-0.06565853,-0.04376309,-0.022584211,-0.024574004,0.017655088,0.009854918,0.04438674,0.020796029,-0.019254468,0.00134776,0.13139346,-0.026797323,-0.01607604,0.0074340017,0.023622308,-0.0013258624,0.08700501,0.005558779,0.060842358,-0.041325405,-0.042769272,-0.12651421,0.009024504,-0.023062536,-0.026712026,0.069832616,0.09236812,-0.011380218,-0.044052526,-0.013109701,0.040660117,-0.005464872,-0.009831429,-0.09551122,0.00021733245,-0.034968425,-0.022704884,-0.022757793,0.02506916,0.04778227,0.03453443,-0.05622501,-0.013816092,-0.028983843,0.007804846,0.009098232,0.06758485,-0.020254087,0.051822606,0.018886028,-0.05583688,0.0036711264,-0.0138858035,-0.02360738,-0.040204886,-0.022663629,-0.049523633,-0.017434724,-0.060692295,0.052591413,0.03364108,0.2036905,0.022125764 +4.2.2.19,"This is the only lyase that is known to be specific for dermatan sulfate as substrate. The minimum substrate length required for catalysis is a tetrasaccharide [2]. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1-3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [5].",384,1.0,-0.08085592,-0.1363604,-0.06003519,-0.053332534,0.01827892,0.056338478,-0.0038799027,0.06066674,0.03441519,-0.00198501,0.078896485,0.0027516396,-0.06319971,0.007976946,-0.07574301,0.018115079,-0.031335868,-0.0075284275,0.012606659,-0.029448811,0.06811646,-0.047832012,-0.066827476,0.009801967,-0.059048794,-0.020197768,0.048406646,0.017402086,-0.034150917,-0.039644323,-0.04910719,-0.07152685,0.0068487846,0.009172857,0.006545082,0.04434926,-0.04638469,-0.046846934,0.028970232,-0.040333427,-0.015388087,0.051525973,0.03648624,-0.04331159,0.01364885,-0.12866996,-0.03272854,0.0133407945,0.004186477,-0.026129175,0.059636798,-0.051904045,-0.006529583,0.072550505,0.03907189,-0.03593738,-0.08859724,0.009105983,0.07961876,0.07951802,-0.0073045148,0.044065855,-0.037087314,-0.08252282,-0.026176395,-0.003321179,0.05645982,-0.05847437,-0.04625852,0.04079312,-0.06953736,-0.013326835,-0.02494868,0.02897752,0.027626006,0.086484335,0.00064793765,-0.046235118,0.00073942204,-0.040473726,0.016081002,0.10575316,0.03072139,0.09978775,-0.024887247,-0.036207605,-0.012733376,0.03567836,0.08337919,0.0028837416,0.07361345,0.036726903,-0.0408475,-0.032387476,-0.0072508324,0.006140477,0.04816257,0.08054514,0.07350212,0.0027030993,0.005006409,-0.019490266,-0.023499595,-0.093969725,-0.08777547,0.06292059,0.0077831727,0.104689576,0.05608247,0.036226086,-0.029480804,0.0322651,-0.05130411,-0.009091914,-0.12470791,0.067482956,0.029051432,-0.033833776,-0.054073684,-0.01751213,0.0046165404,-0.016373713,0.028257921,-0.002235732,-0.01555698,-0.026573488,-0.023676388,1.9122707e-33,0.11476038,0.019586757,0.05290276,-0.034974925,0.008736299,-0.028991316,-0.046414707,-0.0026414662,0.0056423466,0.0061467756,-0.11710657,0.048444577,-0.0589765,0.024000527,-0.0313683,0.07057218,0.07189651,-0.029330192,0.04071188,-0.017031943,-0.021222832,0.05227475,-0.025768895,-0.09475583,0.056832016,-0.0014406078,-0.031037802,0.025967725,0.031832162,-0.006225592,0.00030981452,-0.06365176,0.0013284301,0.013616379,0.09702515,-0.013250617,-0.044136718,-0.007052921,0.047039215,-0.004606285,0.10573498,0.013205469,0.044091534,-0.0072617964,0.02750592,-0.03759194,0.036099732,0.00017716695,-0.031394515,0.09482674,0.050941095,0.006579095,0.039328195,0.030506477,-0.051500563,-0.0076168403,-0.068450905,-0.08673687,0.060556285,0.115636185,0.040179506,0.020627638,-0.019046746,-0.079916656,-0.0034291323,0.028323393,-0.11257002,0.04098505,0.007856303,-0.045219857,-0.037370328,-0.10496053,0.04917846,0.07020009,0.040716242,-0.040156305,0.025070796,0.1034803,-0.0150829395,-0.02447679,-0.07576361,0.017886149,-0.029883817,-0.00080757355,-0.10622976,0.073326625,0.007336583,-0.03611582,-0.064012,-0.016140867,-0.06464336,-0.041801758,-0.01986201,0.061004613,-0.022565465,-4.5201685e-33,0.055442505,-0.11707154,0.044133335,-0.105033,-0.040820822,-0.021778569,0.09413734,-0.009468201,-0.016053239,-0.0408048,0.055545893,0.054114655,0.010308915,-0.023630053,0.012638324,0.08253726,-0.05845694,0.09506052,-0.027413601,-0.021318376,0.015473543,0.091989815,0.04407278,0.020835215,0.06602288,-0.016135378,0.08328891,0.035999693,0.049655728,0.13404436,-0.011001341,-0.038780246,-0.034850083,-0.036031935,-0.042345382,-0.043663904,-0.01258777,-0.08392128,0.0130075365,0.078297935,0.02826903,-0.008664318,0.01893519,0.06343841,0.037723772,0.09796061,-0.0064059775,0.05892707,0.006652109,-0.0024169683,0.0685283,-0.025675835,0.0030596817,0.004999677,0.061708108,0.077285804,0.0061388877,0.064837456,-0.012782652,-0.03701252,-0.037248097,-0.017760243,-0.02822276,-0.080778696,0.051012028,0.063167006,-0.002100967,-0.059398443,0.050913226,-0.06510265,-0.011964331,0.007840426,-0.043086745,-0.049987037,-0.052568607,-0.021720856,-0.074897476,-0.058306724,0.0015664318,0.014146598,-0.0031025354,0.010009177,-0.00244299,-0.042990394,0.037794895,-0.02336742,0.042408034,0.08096197,0.012689056,0.038520668,0.008169459,-0.022257138,0.011236001,0.12604979,-0.0070820646,-4.7372716e-08,0.04948676,0.018913975,0.0054205293,-0.027382296,-0.087957084,0.013609295,0.037117403,-0.022982948,0.016362438,0.017011132,0.036816373,0.1036869,-0.04486855,0.0102035245,-0.042721577,-0.0011427787,-0.020739453,0.016076716,-0.04562584,0.0322293,-0.07758351,-0.007578108,-0.0995964,0.024314994,-0.020007007,-0.10923975,0.054521263,0.024935484,-0.11269954,-0.033831775,0.04706903,0.02445744,-0.05852523,-0.060647674,0.038344096,0.0014691482,-0.060973138,-0.041530874,0.035949226,0.02409682,0.017695798,-0.026789736,-0.026297588,0.026758226,-0.001374669,-0.021602632,-0.015588612,0.10329949,-0.04633874,0.090952784,0.044495292,-0.07590826,-0.053367194,-0.11059799,-0.009619991,-0.09542469,0.01597769,-0.0121138,-0.020731568,-0.017795734,-0.011095662,-0.031634364,0.11481402,-0.03922092 +4.2.3.1,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +4.2.3.2,A pyridoxal-phosphate protein. Also acts on D(or L)-1-aminopropan-2-ol O-phosphate.,384,1.0,-0.049555056,-0.12527288,-0.018541528,-0.09148795,0.07961954,-0.002013414,0.051570974,0.016573388,0.111150764,0.07456021,0.057201356,0.06065802,-0.09074189,0.06669297,-0.009202375,0.049611546,-0.05662328,0.019791787,-0.009224879,-0.028175304,0.1206326,0.062257595,0.03026492,-0.04401111,0.023922158,0.06370327,0.06486788,0.08116687,0.013260345,-0.069531895,0.0014160897,-0.036209337,-0.024714347,-0.061142102,0.050594393,0.05187147,-0.05833144,0.0016886767,-0.04261589,-0.007614495,0.10434663,-0.042250726,0.01166707,-0.01903389,-0.07632858,-0.014294623,0.023865426,0.052762337,0.03972274,-0.038216587,-0.044981163,-0.049670577,-0.049961925,-0.022369137,-0.039790317,0.074951865,0.007818812,0.04371588,-0.034067076,-0.022028595,-0.043074414,0.024685746,0.074823685,0.043766692,0.08961322,-0.026709868,0.0027115862,-0.034490485,-0.057577163,-0.0272159,-0.037397806,-0.014871452,0.10149186,0.021703642,0.038375605,0.03928273,-0.042992372,-0.05908514,0.014095466,-0.031060128,0.041263517,0.03116791,0.024990892,0.071603835,0.007574793,0.01978019,0.006707685,0.0022316976,0.018878078,-0.043332603,-0.027299095,-0.028120711,0.014223656,0.0415072,-0.045322444,0.003025169,0.04796756,0.028794663,-0.07571476,-0.027816938,-0.04170528,0.04543723,-0.0265825,-0.049613964,-0.08690958,-0.0072625307,-0.056952644,0.013503687,-0.033515472,-0.04396764,-0.008894573,0.008470624,0.025692912,0.024350502,-0.053560164,-0.018508539,0.03485757,0.0008565066,-0.03819665,0.0016034385,-0.013188626,-0.05245077,-0.023988495,0.09588007,-0.08408736,0.01334409,-0.055212058,-1.8961106e-33,0.07906256,0.013407523,0.035620347,0.040653408,0.0052652447,-0.037294406,-0.06893394,-0.064610206,-0.036228593,-0.020421818,-0.052129548,-0.052722752,0.075103015,0.031196874,-0.0387174,-0.0075461613,-0.034496702,0.04422388,0.0622291,-0.04260844,0.08851649,0.13514657,-0.033020046,0.073806204,0.014267329,0.05193925,-0.05661812,-0.005038041,-0.013069237,0.0059101353,-0.010532185,-0.07657851,-0.13462369,-0.0062886137,0.036260955,-0.08675237,-0.052042127,-0.10796276,0.0270123,-0.038647186,-0.04684305,-0.06143656,-0.04860366,0.043449797,-0.0001597772,-0.087315805,-0.0042396714,0.0730296,-0.02514375,0.05441687,0.054061346,-0.07877576,0.06827862,-0.024960993,-0.12883762,-0.045593552,-0.08490167,-0.07766964,0.038199592,0.06904438,0.036878902,-0.004221907,-0.055746417,0.017770445,-0.0203539,-0.071274444,0.009730883,-0.07601791,0.049065415,0.05359214,0.02503544,-0.044771504,0.07725683,0.015282844,-0.0028057822,-0.022004725,-0.030526713,0.029547745,-0.021365903,0.06698751,0.014890227,-0.08108816,-0.0506722,-0.0442281,-0.05100516,-0.0022918838,0.044834744,-0.09219471,-0.015864508,0.0023369826,0.035516202,-0.09993544,-0.06154662,0.009722172,0.034586973,-1.4282928e-34,0.02482368,-0.047314744,0.08697763,-0.016288562,-0.06986026,-0.0010883594,0.071014084,0.0032167926,0.041600052,-0.031033812,0.033349738,-0.02287039,-0.033525728,-0.059984185,-0.018348426,0.024125485,-0.048258502,-0.004507333,0.035628676,0.050332457,-0.017391283,0.0017684255,0.0007948545,0.0886976,0.06578746,0.06672406,0.016686818,-0.004567628,-0.055005748,0.061931822,0.03310691,0.067390874,-0.02104807,-0.038477574,-0.053385444,0.022521956,-0.04435466,-0.06965592,-0.019160928,-0.014573203,-0.0055475016,0.037107773,0.10162289,-0.0038347747,-0.00047276178,0.024623103,-0.0023022417,0.0031730288,-0.024364738,-0.055855647,0.010592178,0.085413404,0.014245094,-0.0049366094,0.04329151,0.04628331,-0.0120345075,0.032354727,-0.019053077,0.032523915,0.022805344,-0.07347572,0.0012759217,0.115751505,0.03264859,0.06253942,0.04210054,0.021040661,0.060648635,0.03816117,0.08242974,0.050685853,0.07311263,0.051344983,-0.063474275,-0.018535722,-0.059269264,0.058597226,0.02613265,0.024794929,-0.03636217,-0.04446986,-0.01822618,-0.039094288,-0.005351423,-0.0627409,0.056208976,0.10527291,-0.010011477,0.035564218,-0.00038091763,-0.002634545,-0.023296794,0.078189805,0.08947075,-3.1045477e-08,0.06535368,-0.041865952,0.051939633,-0.07234586,-0.012283,-0.03967637,0.05350487,0.011428662,0.063036226,0.004069687,-0.0020841581,0.043182876,0.036427774,-0.039825983,0.093118034,0.09727825,-0.019197501,0.041687787,-0.017299708,-0.048062973,-0.019683149,-0.0017165468,-0.120947964,0.01855938,0.019846708,-0.026451068,0.007850858,0.065003164,0.044707056,-0.016689325,0.051059913,-0.053408705,0.014744407,-0.104369484,-0.008370576,0.088631116,-0.046009738,-0.06561319,-0.0441022,0.006671365,-0.037978284,0.012470894,0.050007187,-0.01465701,-0.0063537685,0.094428375,-0.044833686,0.026870819,-0.05123762,-0.024718294,0.033199966,-0.0070738583,-0.08614564,-0.0654618,-0.19400264,0.031243639,-0.010897255,-0.0055678464,0.015460337,-0.082175635,-0.04652114,0.015268366,0.07144814,-0.03822281 +4.2.3.3,Does not act on D-glyceraldehyde 3-phosphate.,384,0.99999994,-0.05171095,-0.10486472,-0.0024446303,-0.071154594,-0.029180095,-0.12184985,-0.02297876,-0.050721694,0.017473757,0.03725686,0.022666696,0.029343944,-0.08724164,0.03871302,-0.059052654,-0.039967038,0.02866199,0.030122323,-0.010020667,0.040471748,0.07891421,0.036660008,0.04971649,-0.037172604,0.101801924,0.0487221,0.036694456,0.0006640791,0.01724725,-0.059060797,-0.061010625,-0.06421391,-0.036872156,-0.032476064,0.08297333,0.060973424,-0.080054894,0.033004463,-0.012248985,0.034166325,0.0689117,-0.01928128,-0.0030124055,-0.0049964255,-0.017340215,-0.0047785537,-0.07858524,-0.025319804,-0.030441962,0.03385558,-0.07087966,-0.08559214,-0.030672956,0.021518782,-0.01243713,-0.0076389466,-0.04523922,0.13684098,-0.011701846,-0.009251819,0.010457884,-0.0020910904,0.067123584,0.026256429,0.07412614,-0.026255991,0.060042337,-0.085270315,-0.05222823,-0.00745137,0.011738719,-0.033117108,0.0059332205,0.020866027,-0.0012486649,0.071288414,-0.049059913,-0.018917248,0.04539143,-0.019753952,0.04299377,0.0066899303,0.10683975,0.12343492,-0.0026174942,0.019534368,-0.059302777,-0.0012603303,-0.08588496,-0.005694229,-0.011221583,0.03337508,-0.00091902626,0.010191486,-0.056272235,0.0099319285,0.018889977,0.012414543,-0.09890484,-0.0135223195,-0.046334352,0.094650336,-0.09960978,-0.025188854,-0.06089413,0.046651535,-0.0859703,-0.006367146,-0.038411357,-0.015914623,0.012957837,0.08559271,0.06857851,0.039916407,-0.112298176,0.018887598,0.014620285,-0.032997996,-0.017960502,-0.026601272,-0.016303822,-0.073774815,0.04313314,0.032695435,-0.07072194,0.029786402,0.04654887,-2.9372782e-34,0.11423713,-0.027045172,0.018448794,-0.029531393,-0.05280844,-0.0014041774,-0.08177917,-0.056285247,-0.05883551,0.005015224,-0.009201896,-0.071638785,0.06360374,0.023081494,0.0005102002,0.11142576,0.0016707933,-0.0017153755,0.06507937,-0.061538417,0.12880425,0.061089255,-0.068299994,0.004275195,-0.020357348,0.03152284,-0.029176062,0.04860299,0.05594589,-0.0052779466,-0.011292625,-0.11537466,-0.004626326,0.025296558,-0.015546417,0.0049573616,-0.101987965,-0.079100594,0.0023639575,0.017922016,0.006313583,-0.013242371,0.015248232,-0.057830766,0.02208919,-0.016035818,0.051495593,-0.013591821,-0.05298756,0.07740589,0.07835529,-0.023963979,0.058959022,0.0018274329,-0.058774706,0.022125416,-0.0062422873,-0.02537419,0.024462346,0.034802344,0.001268527,0.009968869,0.019465849,-0.021488037,0.0014872793,0.02201953,-0.10890347,-0.040459,-0.035209514,0.040892277,0.019894578,-0.054484095,0.095021784,0.03298877,-0.01450713,-0.07168717,0.049184673,0.034507755,-0.028976042,-0.01926606,0.07036167,-0.056385566,0.00012666397,-0.006804082,-0.03240149,0.0012139214,-0.031416908,-0.117766514,-0.0015474462,0.03167992,0.06206061,-0.06823901,-0.090543516,-0.009670559,-0.028268607,-1.2709375e-33,0.05327333,-0.0005235299,0.07197241,-0.00747716,-0.077991724,0.051926866,0.0002132728,0.039810594,0.08500073,-0.063202895,0.08988375,0.058758814,-0.04696111,-0.035270963,-0.028361112,0.077854194,0.014669463,-0.0064043077,-0.02905414,-0.009323732,0.03972036,0.09092445,-0.032500073,0.14008395,0.018779958,0.017842587,0.0128819235,-0.013474558,0.01208783,0.049717456,0.072421804,0.06708226,-0.0962371,-0.060436763,-0.044740137,0.013582496,-0.056739647,-0.030484442,-0.07861488,-0.028589357,0.001887834,0.03241562,0.0666719,0.062686704,0.04031744,0.067284204,0.007596583,0.016351251,0.04429197,0.0021719022,-0.028173044,-0.003938695,0.030352846,0.06052695,0.12202926,0.08073157,0.077936955,-0.007023356,-0.090662204,0.011393355,0.027901066,-0.027229305,0.0379888,-0.07274381,0.05171981,0.10433034,-0.022522407,0.1160536,0.09173452,0.013147995,0.057025533,-0.0005879473,0.037421495,-0.01806778,-0.04024373,0.013147293,-0.0696993,0.027351838,0.008424546,-0.017267173,0.013928735,0.057951473,-0.031875756,-0.0075742486,0.058795687,-0.043554436,-0.041299433,0.08836369,-0.05723456,0.021147165,-0.045011584,-0.012223157,0.01797917,0.030816413,0.08319905,-2.1862983e-08,0.09794967,-0.013086098,0.04298984,-0.07645971,-0.060607504,-0.032127354,0.04814733,0.005064874,0.0012125467,-0.020080797,-0.048973206,0.027275762,-1.879085e-05,-0.061750557,0.03897657,0.01626466,-0.014546646,0.0006656065,-0.076065026,-0.045798533,-0.12997966,-0.014243827,-0.08973937,0.036051117,-0.022414686,0.006823277,0.08849811,-0.02219977,0.00039649848,-0.0014405845,0.0509995,0.025332166,0.0051073716,-0.02267567,-0.06541059,-0.007221441,0.019080527,0.019297391,-0.027458379,0.0068122246,-0.046194583,-0.0017337961,0.026002428,0.06521539,-0.069138594,0.024455918,-0.01712831,0.009550982,-0.05834022,0.016103225,0.037427746,0.009584415,-0.09048337,-0.054134645,-0.10109101,0.005216731,0.0059835156,0.018389864,0.003807092,-0.0749193,0.029530015,-0.08023465,0.06519655,-0.0032907058 +4.2.3.4,Requires Co2+ and bound NAD+. The hydrogen atoms on C-7 of the substrate are retained on C-2 of the product.,384,0.99999994,-0.067696445,0.03193258,-0.030189052,0.0077357218,0.028553577,0.03712454,-0.028213812,0.08451825,-0.031266704,0.0021178774,0.0026795324,-0.09086225,-0.14244874,0.061121598,-0.01575706,-0.04700175,-0.05030192,-0.03725581,0.042341944,-0.027798312,0.0136768045,-0.0670021,0.01464858,0.0009646249,0.031029511,0.050925057,0.034931835,0.016947705,0.08225662,-0.08470009,-0.06331478,-0.0009947037,0.012586656,-0.0026073398,0.011332303,0.024067115,-0.018869808,-0.069800496,-0.013960938,0.036570717,0.013419123,-0.026921254,-0.007187829,0.038907308,-0.05940254,-0.027822178,0.096326925,0.03709985,0.056048658,-0.060377892,-0.046092346,-0.021408102,-0.056554854,0.0068241847,-0.01266821,0.0100873215,-0.0020734253,-0.007914929,0.006944243,-0.05113271,0.045150723,-0.08346965,-0.026930539,0.034097385,-0.0048002,-0.112156995,0.050164573,-0.03467399,-0.07008092,0.025735978,-0.053670414,0.0031605046,-0.046237078,-0.010075972,0.064219385,0.06262803,-0.050934378,-0.11443863,0.06340605,-0.011683445,0.007266128,0.06795709,-0.03385779,0.05885008,0.02204247,-0.0035727478,-0.012404824,-0.01885918,-0.029094452,-0.027795989,0.0023486523,0.025097528,-0.03954724,0.01645784,-0.119223066,0.031017035,0.13631728,0.029045843,-0.004777246,0.031174792,0.003695159,0.08264043,-0.03751602,-0.004579748,-0.06803139,-0.00972988,-0.028181996,0.14799818,0.011461258,0.03110007,-0.0028751579,0.022791607,0.016315274,0.008757019,-0.027516983,0.06006738,0.041779485,-0.0001612156,-0.051622346,-0.011069204,-0.015918393,0.027350623,0.024400229,0.035996452,-0.06208771,-0.048443295,-0.014546728,-2.1825583e-34,0.056250267,-0.02720044,0.023465006,0.034703176,-0.081763424,-0.02342152,-0.10451518,-0.006120055,-0.022203613,-0.06178383,-0.019464197,-0.122231,0.031269718,0.003556608,0.0070134425,0.010869118,-0.011226179,-0.053320084,-0.038883965,0.0063257776,-0.014794972,0.0039238553,-0.053811576,0.025340583,0.04209862,0.050515104,0.023434194,0.07295708,-0.042837217,-0.02765358,0.025244176,0.022188667,-0.008035226,0.057394102,0.11064008,-0.014378381,-0.05425683,0.009017606,0.014256718,0.0025642142,0.020229833,0.04548957,0.049593046,-0.028288104,0.092099845,-0.10913532,0.040623076,0.07845893,0.0044285585,0.08369577,0.041166153,0.0051462045,0.023824196,0.013206214,0.026717873,0.029170582,-0.017941078,-0.022709416,0.0097959135,0.03321889,-0.017402802,0.060631715,-0.028276661,0.112618536,-0.03512162,0.08821879,-0.1461957,-0.011725824,-0.026709272,0.028557038,-0.021628892,0.014346208,0.08359129,0.0068217316,0.0268322,-0.012789842,-0.0196495,-0.024335638,0.07156433,0.0028054581,0.0032209307,-0.031113513,-0.02271548,-0.06407275,-0.09171965,-0.047517966,-0.043843642,-0.074563265,-0.032714162,0.068119824,0.029849896,-0.05028538,0.024506908,-0.04453509,-0.002109228,-3.2340094e-33,0.06531553,-0.04368864,0.0031927654,-0.15713464,-0.04180208,0.064869925,0.022829087,-0.15936574,-0.10099045,-0.054702163,0.0426813,0.03393197,-0.004278695,0.043324154,-0.027502984,0.062162995,-0.055789713,0.061204772,0.017797077,-0.014027428,0.035360552,0.063902184,0.008879992,0.06886903,0.037652373,-0.065061085,-0.034403745,0.0034873665,0.06847866,0.03337115,-0.028623993,-0.097155824,-0.049493965,-0.007890082,-0.015611021,-0.0025984105,-0.018675093,0.02583756,-0.017026708,0.024582831,0.014651577,-0.07371794,-0.052930214,-0.026063671,0.0113198375,0.050318602,0.040558275,-0.073197335,-0.012702334,0.020207644,0.015667254,-0.051471893,-0.047731165,-0.06315758,-0.014985157,0.082652755,0.01436132,0.05384973,0.11679446,-0.013674878,0.03329591,-0.02367132,0.003437454,-0.042534526,0.06809796,-0.025743363,-0.029732749,0.11450219,0.041019775,-0.055934608,0.04560448,0.1016898,0.07321027,-0.04208224,-0.06562971,-0.07410396,-0.055036955,-0.011157479,-0.02131688,0.0022976515,-0.042603824,0.015403449,0.00016852116,-0.0234558,0.08356343,-0.056731056,0.039073903,-0.054775134,-0.036900003,0.088083155,0.043808114,0.0517351,0.010749983,0.06394738,0.030700544,-2.774209e-08,0.042380877,-0.052623603,0.037423056,-0.06786134,0.007869439,0.073800415,0.05441856,-0.08491449,0.04046998,-0.040294997,-0.030051345,0.08111575,0.066894725,0.08799971,0.05437683,-0.042348582,-0.101386644,-0.042021956,-0.033801675,-0.047802046,-0.09980877,-0.119630724,-0.027595486,0.07972058,-0.014809301,-0.08367348,0.016824394,0.10261152,-0.03158858,-0.03962553,0.040720128,0.01663269,0.04539759,-0.013777098,0.0018466254,-0.008184989,0.014743787,-0.00030655225,-0.020791529,0.018952511,-0.04707938,0.048156444,-0.036433518,0.042387646,0.08150815,0.041932102,-0.020665878,0.05113912,-0.018211298,0.0542171,0.07742108,-0.024301669,0.004345326,-0.074614994,0.04164379,-0.05028232,0.014345583,0.038361993,0.03749775,-0.06419398,0.04618086,0.058956366,0.09663163,-0.027909784 +4.2.3.5,"Requires FMN. The reaction goes via a radical mechanism that involves reduced FMN and its semiquinone (FMNH(.)). Shikimate is numbered so that the double-bond is between C-1 and C-2, but some earlier papers numbered the ring in the reverse direction.",384,1.0,-0.036827195,-0.0038876373,-0.034168027,0.054178037,-0.07037264,0.057231605,-0.06251113,0.030503228,0.106050126,-0.036319043,0.0900378,-0.029040935,0.0074559934,-0.0074357735,-0.013393002,0.009241999,-0.128311,0.052158676,-0.02238265,-0.011611618,-0.008405009,-0.11133358,0.009544744,-0.019915026,-0.020401403,0.007182571,0.03939436,-0.0021520588,0.029321136,-0.054966144,0.11522696,0.04929646,-0.023397308,0.0367583,-0.09351032,0.044011787,-0.035728537,-0.009602946,-0.019371375,0.030801298,-0.0016485448,-0.012998594,0.018882945,-0.1275902,0.0334404,0.0056862226,-0.030135442,0.039255604,0.030892914,-0.0001714171,0.020090014,0.02442578,-0.017243162,0.07761123,0.08494463,-0.021867778,-0.0888473,-0.03774745,0.010338352,0.04119673,0.016099492,0.058132432,-0.0630149,-0.04539724,0.01448122,-0.059910245,-0.00818335,-0.037998877,0.037263952,0.029077455,0.05528447,-0.047371995,-0.035541665,-0.09323847,0.035511076,-0.0040136017,-0.021317644,-0.031464692,-0.011676563,-0.019164924,-0.038665436,-0.023245357,0.10483434,0.06568862,0.045180835,0.009826848,0.008770392,-0.01626533,-0.009589703,0.056781765,0.027237825,0.008167101,-0.057153348,-0.03580156,0.010388789,0.018865881,0.057575792,0.1604237,-0.0043904353,0.032813497,0.046798687,-0.009269076,-0.13202134,-0.07470662,-0.041510478,-0.02317977,0.003340846,0.059823304,0.023159968,-0.035468295,0.041054744,-0.024474269,0.0065598465,-0.056272537,-0.07727274,0.056772932,0.030215366,-0.014079005,0.004513147,0.0108536985,-0.02951786,0.04416099,-0.03176487,0.07308302,-0.06672256,-0.01745317,-0.08829943,-4.880201e-34,0.034992523,0.103024624,0.05366053,-0.03635927,-0.12873578,-0.053500813,-0.042897303,-0.09872337,-0.07072444,-0.073437236,-0.016272614,0.0056188167,0.006859344,-0.065718785,-0.08140024,-0.08057855,-0.007984012,-0.043140434,0.006766537,0.0017074952,0.018391626,0.046707347,0.018784784,-0.024458393,0.017550375,0.0021587017,0.0606729,-0.045951504,0.017951282,0.02260946,-0.030540535,0.033627726,-0.0368177,0.058390886,0.07799399,0.049791634,-0.0126780225,0.013815327,-0.047081936,0.043793403,0.14311261,-0.02101463,-0.059338644,0.03291042,0.055531256,0.005242481,-0.043755822,0.08191694,0.06809715,0.061684255,0.056611203,0.049556904,0.015144765,0.031193957,-0.044402376,-0.06264009,0.04691591,-0.08360708,-0.021439908,0.086323604,-0.032697495,-0.019173793,-0.057723958,0.017157134,0.02661328,-0.013647757,-0.036079273,0.05017705,-0.024265608,0.0052887783,-0.042544942,0.01269449,0.06765825,0.07094629,0.021681078,-0.0022776932,-0.026783027,-0.039004937,0.041902147,0.07338013,-0.01807696,0.0018964026,-0.010040239,-0.001024111,-0.051375486,-0.06977482,-0.031152133,-0.024770409,-0.04326683,0.016480153,0.064222015,0.017371636,-0.012422775,0.007968009,0.036937173,-2.3278012e-33,-0.04151935,-0.061827496,-0.09000859,0.042994555,-0.093733214,0.012268038,-0.024798572,-0.0906444,0.006167475,0.02374985,0.15104324,-0.08661335,-0.021992065,0.018526424,0.0017411532,-0.056337617,0.028592587,0.123706505,-0.019384919,0.017616255,-0.03559223,0.03516448,-0.039356846,0.081797145,-0.0026417158,0.074067004,0.011135865,0.017389787,0.070838675,0.06362547,0.032190323,-0.08034304,-0.02476815,0.0092979055,0.018367669,0.039539307,-0.022546161,-0.03452666,0.014911945,-0.00077325286,0.010319157,0.0043462007,0.039623626,0.1240805,0.034279216,0.039574035,0.0060270345,0.0763874,0.019710917,-0.106895894,0.01409872,0.006353927,0.015369937,-0.011573201,-0.0004034068,0.01585944,6.349529e-05,-0.016779063,0.07021081,0.011794372,0.018244043,-0.06475921,0.062397912,-0.10092185,-0.05221183,-0.017021786,0.022746645,0.0048942636,0.061571654,-0.06926706,0.05275919,0.107854925,0.051748622,-0.03435515,-0.054589555,-0.023055036,0.003116902,-0.022888636,0.023111152,-0.01823739,0.029045539,0.01348969,0.03377561,-0.06281459,0.034145623,-0.07245854,0.055472337,0.020469768,-0.01391134,-0.0130583225,0.015587306,0.04931542,-0.0041793627,0.045930266,0.027516568,-4.0096133e-08,0.014063525,-0.084916316,-0.05352808,-0.03022459,0.018435327,0.04997426,-0.027703553,-0.080198266,-0.05106444,-0.08163095,0.0034239013,0.09151249,-0.053567655,-0.06022035,0.09213803,-0.006216455,0.08244775,0.045704033,-0.02726024,-0.045963295,-0.14618033,-0.024787974,-0.035632018,-0.06098002,-0.0662664,-0.014062361,0.051097397,0.07423793,0.020924073,-0.055878457,0.055901363,-0.047388256,-0.08253275,0.009933604,-0.035242785,-0.009713818,-0.026438458,0.0023736602,0.09987234,-0.061834954,-0.010717489,0.055013932,-0.044548787,0.050371096,-0.031926624,0.009696859,0.004270104,-0.049413644,-0.071668565,0.014833994,-0.001655746,-0.011329123,0.06567746,-0.061465185,-0.13603109,0.06766612,-0.0111232465,-0.020957196,0.008461124,-0.08212566,-0.06557994,0.011351661,0.03430129,0.06478534 +4.2.3.7,"Isolated from Streptomyces avermitilis. The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics. The 9si hydrogen of farnesyl diphosphate undergoes a 1,2-hydride shift where it becomes the 1alpha hydrogen of pentalenene.",384,1.0,-0.032543972,0.016643072,-0.12946829,-0.038749173,-0.009881644,0.011590059,-0.0694647,0.044812784,0.06262267,-0.07126684,0.06865752,-0.027459672,-0.06894471,0.023997927,-0.04101146,-0.034246176,-0.07493001,-0.039344184,0.060907044,-0.010475526,0.116259366,0.05208811,0.03252469,-0.06604204,0.08150157,0.04519777,0.030987322,0.027105467,0.041964024,-0.12839761,0.05552385,-0.020379668,0.034388594,-0.11798817,0.10459236,0.0879221,-0.04281652,-0.043690417,0.13219404,0.088701114,0.01178775,-0.043164045,0.049764294,-0.0050681294,-0.052585747,-0.012492648,0.054893065,0.110490285,-0.037743624,-0.050038,-0.01328944,-0.06469157,-0.018444182,0.039702147,0.035710227,-0.041652616,0.028595043,0.009189764,-0.0022311052,-0.106360234,0.08509102,0.060227226,0.0073800795,-0.040791918,-0.109184824,-0.03199467,0.018483626,-0.08496765,0.105371185,-0.04925368,-0.07239179,0.022604804,0.0034493976,0.003941757,0.015714902,-0.003208666,-0.028892808,-0.02315376,0.00039881223,-0.03818381,0.07944848,0.025882127,-0.0075595872,0.086977795,0.040044133,-0.016608875,-0.008529377,0.04684878,0.043053843,-0.0072728842,0.008516686,-0.058264963,-0.017522844,-0.066886015,-0.08849821,0.021235464,-0.015866598,-0.0029175126,0.0030657414,0.015147788,0.019228611,0.009922968,-0.04162576,0.0053309943,-0.0017488098,0.053033393,-0.06182273,0.020620571,0.0382806,-0.039146814,-0.028877167,0.024376484,8.1386606e-05,-0.039067496,-0.020017393,-0.015778417,0.033684593,-0.05047173,-0.014740042,0.019113645,-0.027223118,0.019985408,0.00024854217,0.048897,0.05364138,0.064381935,-0.12697603,3.0981638e-33,0.024728358,0.05954786,0.011789917,-0.061052054,0.007936521,-0.015408408,-0.073445395,-0.030394696,-0.044281505,-0.051507346,-0.07825849,-0.111216255,0.018013394,0.008253893,-0.03344025,-0.025605563,0.0026107095,0.08116245,0.0691083,-0.028053127,0.015711978,0.079181895,-0.07742443,0.0046297577,0.031232717,0.04315297,0.016149443,0.013499237,0.1338709,-0.016760569,0.023512645,-0.053819943,-0.044103347,-0.037648365,0.087115586,-0.033607155,-0.07044008,-0.09429917,0.04707249,0.017479176,0.01322633,0.016329398,-0.025058359,-0.030518325,0.113610625,0.00022695352,-0.024143986,0.0367412,0.09224715,-0.018700197,0.027656645,-0.02119269,0.08228425,0.021700576,-0.08979092,-0.03687434,-0.033755284,0.016531512,0.07965293,0.042148136,-0.014819568,0.07143141,-0.00943062,-0.01808847,0.015568209,0.0004563634,-0.040887397,-0.029016936,-0.022160849,0.064393446,-0.076573655,-0.054224852,-0.0005964484,0.003962448,-0.0022273855,0.05101694,-0.029725926,-0.038009107,0.060009956,-0.009095639,-0.022403436,0.0016075574,0.030967047,-0.07741372,-0.07870966,-0.022733118,-0.022601651,-0.059888802,-0.010788612,0.10590614,-0.011149159,-0.115495756,-0.10412361,0.008423958,0.050448567,-3.2266864e-33,0.03559078,-0.04024857,0.04389567,-0.11030243,-0.039130315,0.085124835,-0.024559248,0.0446985,-0.001688825,-0.0017320903,0.015753644,-0.026245596,-0.0049637607,-0.0741062,0.020555206,-0.0004974768,0.07034804,0.1444853,0.016922643,0.046156157,-0.027280122,0.051109254,0.0056049647,0.035794634,0.040725745,0.023975167,0.06831229,0.070177,0.001297788,0.038159765,0.022216404,-0.05660689,-0.044942293,-0.025427531,-0.091618896,0.08644686,-0.0637799,0.007071984,0.06604705,0.009927552,0.048751622,-0.05246233,0.03347858,0.0762381,0.048068833,0.065314755,-0.09652663,0.049555045,0.0005544188,-0.03840797,0.01905965,0.03118966,0.04038377,-0.00026273172,0.024026219,-0.02674744,0.0074024578,-0.013644852,0.020242037,-0.04542446,-0.014798246,-0.0043948237,-0.0063504926,0.018559732,0.09510787,-0.005680412,-0.018190548,0.029688526,0.04786155,-0.04203639,0.056145385,0.06501376,0.0122099435,0.0122067835,0.02852076,0.032000724,-0.05937639,-0.08487787,0.025258943,-0.050474286,-0.018921327,-0.067032516,0.06231707,-0.045575574,-0.018478401,-0.035786986,0.06581038,0.070920885,0.029089687,0.07367987,-0.00221588,0.058922105,-0.022482771,0.03858034,0.07960509,-3.3261355e-08,0.049750052,-0.060127195,0.09010121,0.002349428,-0.017184641,-0.014988369,-0.0073557,-0.011699259,-0.00016371526,0.04900737,-0.028970547,-0.016508773,0.059024565,-0.07888957,0.025879383,0.035914145,-0.027556662,-0.02787401,-0.036368284,-0.03301128,-0.055536576,0.023282783,-0.039267454,0.018542023,0.027730059,-0.054644804,0.069887444,0.0017558105,-0.012758627,-0.0311905,0.07271339,-0.0066849953,-0.043546606,0.011878667,-0.054106724,0.0013704493,-0.053299762,0.0047690687,-0.00079624227,-0.01609682,0.029893255,-0.018080095,-0.051979408,0.020574566,-0.09448264,0.055787202,-0.050365143,-0.03372617,-0.053608548,-0.058809403,0.03242082,0.0139545575,-0.032817505,0.01568701,-0.11187703,-0.0147859845,-0.032449454,-0.030437866,-0.05152608,-0.026589492,-0.025964262,-0.002269438,0.1912147,0.018617887 +4.2.3.8,The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene.,384,1.0,-0.046838183,-0.019743925,-0.05185536,0.026376823,-0.04909814,0.022221377,-0.085417554,0.061879452,0.066534065,0.053189974,0.0758707,-0.048356473,-0.034102324,-0.052223086,-0.039961804,-0.041694276,0.055206634,0.06895999,-0.032721218,-0.07592062,0.063270554,0.035399877,0.010018955,0.03671862,-0.009133177,-0.018771263,-0.0024598641,-0.050016,0.013466159,-0.094901,-0.012699106,0.017606324,-0.0109671615,-0.10538118,-0.05165916,-0.0017671876,0.007190448,0.0009522731,0.13023277,-0.0017395864,0.012653674,0.0136105055,0.064753406,-0.0136794895,0.031246748,-0.0414243,-0.044089895,0.08217917,0.093135625,-0.090202026,-0.076622605,0.055953532,-0.011001761,0.024309693,-0.0064763515,-0.046870753,0.06087363,-0.051491585,-0.0036520346,0.046162248,-0.026211336,0.01644163,0.0068266685,0.006245399,-0.14983621,-0.045575224,-0.07661149,0.043604232,0.03849447,0.018131854,-0.04723049,-0.106735446,-0.046880875,-0.06016635,0.017664291,0.07737356,0.039079756,0.038627554,0.045706365,-0.022018185,0.089911684,0.014464735,0.09637205,0.025171997,0.0270492,0.06728367,0.03548444,0.01475128,0.06012808,0.03297538,0.05115408,0.029873485,-0.023416415,0.02904611,-0.09703016,0.011491643,0.008173777,0.09509914,-0.036293805,-0.013387452,-0.010362132,-0.08771438,-0.065496705,-0.054146457,-0.06290212,0.018621717,-0.019057676,0.021202987,0.059744775,-0.03976256,0.023629049,0.02891379,-0.08121945,0.023285143,-0.046756584,-0.01455333,0.10846948,-0.038423255,0.061734892,-0.07633416,0.082338095,-0.028890617,0.036136847,0.0017369955,-0.036155067,-0.062474176,0.07216779,1.9485408e-33,-0.0048507657,-0.016606398,-0.02838877,-0.02713282,0.02691069,-0.044540983,-0.05332602,0.041407548,-0.029680343,-0.0759764,-0.07399389,-0.0124443555,-0.07058583,0.023443965,0.013884589,0.021389956,-0.012760736,-0.026147034,0.022132019,-0.07653361,0.02959448,0.043367796,-0.075374275,0.014668191,0.038046397,0.06407785,-0.019850032,-0.05695498,0.026594955,-0.010324616,0.029531665,-0.08524714,0.025570858,0.036927637,-0.023188552,0.00034423042,0.0020052807,-0.008941435,-0.07856816,0.037891455,-0.040484972,-0.010470713,-0.043638494,0.00075470156,0.04949442,-0.008879261,-0.026643524,0.05509714,0.04432889,0.055101898,0.03480885,0.015212585,0.100301065,0.09999024,0.0018632245,0.06818651,0.018516107,0.029609567,0.067096025,0.066365615,-0.05195515,0.07806642,-0.05874669,0.03275355,-0.045311604,-0.05530507,-0.0037539026,-0.0811194,0.03565721,0.0740542,-0.0323443,0.018889286,-0.017800542,0.025874732,0.052630514,-0.046434354,-0.061796945,0.010107265,-0.015215268,0.084962286,0.026548367,-0.0131036565,-0.010791687,0.020115871,-0.061183922,0.051609557,-0.07483972,0.030366456,0.069696985,0.030541753,0.025257047,-0.0065665296,-0.105904065,0.109789886,0.048621994,-2.6425758e-33,0.09599255,-0.120298006,0.10992846,0.05933301,-0.09594774,0.054582957,-0.04014091,-0.029260086,0.09985098,-0.03326255,-0.005711011,-0.050139934,0.036145926,0.026970016,-0.042787556,0.024419172,-0.00047580933,0.0688366,-0.08123737,-0.013196667,0.0027086707,0.12504314,0.019462286,0.04120834,0.01463699,-0.07276439,0.075992174,0.04824986,-0.04217504,0.051207915,0.037040845,-0.06019619,0.045025606,-0.076161414,-0.08634272,0.057324294,-0.043051973,0.008671099,-0.023915602,0.065765984,-0.025203675,-0.015541026,-0.06282496,0.026435144,0.017254401,0.03539265,-0.11531026,0.074185476,0.060351722,0.035774093,0.06698413,0.0057919226,0.0078268,-0.00037613604,-0.0031049675,-0.083324954,-0.005014804,-0.0301466,0.0007121982,0.05061457,0.017531177,-0.057519585,0.013336698,-0.07556723,0.110508434,0.020233829,0.005719324,0.043356154,0.11823121,-0.04124738,0.0860141,0.011563651,-0.03833998,0.049402107,0.016687606,0.057244707,-0.019124957,-0.08452812,0.0117069995,0.013548541,0.012228509,-0.014142504,0.056444723,-0.037042636,-0.07595048,0.01587875,0.033291467,0.053397074,-0.009763716,0.06507562,0.0072488203,0.013662866,-0.017669367,0.050603412,0.05615843,-2.6042578e-08,0.035040617,-0.036253132,-0.012261933,-0.029804973,-0.10500386,0.00204426,0.0704107,-0.0080230115,0.008623301,0.0187798,-0.052668184,0.07029545,-0.06345505,0.043746103,0.010853772,0.016933547,0.013334286,0.0031785816,0.004837582,-0.0232366,0.016381873,-0.012462253,-0.00021995083,-0.09135235,-0.026321141,-0.08806313,0.006690761,-0.02634022,0.025915548,-0.017404916,-0.007404224,-0.013974877,-0.025244184,-0.0079728,-0.046533164,0.050839614,-0.099445194,-0.034309786,0.02883782,0.06803865,-0.0037674876,-0.05389532,-0.018541887,-0.04350269,-0.08458548,0.010764611,-0.028955448,0.0220903,-0.005602091,-0.033255998,0.02487697,0.00030102563,0.0050816564,-0.03957833,-0.09807835,-0.020995256,0.045148123,0.020308988,-0.01328035,-0.09928697,-0.016431425,-0.050296508,0.1315539,0.018146725 +4.2.3.9,"The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti [5] (see also EC 4.2.3.23, germacrene-A synthase). The enzyme from Penicillium roqueforti requires Mg2+. Mn2+ can partially substitute, at low concentrations. Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi.",384,0.99999994,0.0398977,-0.010946086,-0.08174696,0.042477842,0.063365266,-0.025304303,0.003946603,0.013060188,0.07566547,-0.06298394,0.05605387,0.021522844,0.05287184,0.007902999,-0.10043895,-0.021065833,-0.013160371,0.0061916127,-0.031300053,0.039000403,0.073178396,0.006910522,0.015627144,-0.014253829,0.07709172,-0.029339772,-0.0061620222,-0.03034048,-0.01900124,-0.05802006,-0.022615386,0.023688413,0.04429109,-0.120543234,0.040942095,0.062994026,-0.08881486,0.040540762,0.086384624,0.023726221,0.053471025,-0.039435707,0.06156841,-0.054876167,-0.08944696,-0.07321936,0.014128019,-0.048671123,0.0016562649,0.045246113,-0.07370607,-0.07961972,-0.061943956,0.034399033,0.05391634,0.026024837,-0.03971319,-0.0706446,-0.033424538,0.02587555,0.038442217,0.056788832,-0.059823666,-0.06270916,-0.0916399,-0.0061415057,0.04066873,-0.11949235,0.024542728,0.021731665,-0.044340026,-0.024589978,-0.09475143,0.029623339,0.026025567,0.07297392,-0.014873612,0.02357375,-0.00905974,-0.008013284,0.020744368,0.04655321,0.035138667,0.015020319,0.054429498,0.004337753,0.051418524,0.047146767,0.059734702,0.04553536,0.06020249,0.102651775,0.0047392016,-0.035268392,-0.008885453,0.028061075,0.0154932095,-0.00038520276,0.009964124,-0.022959176,0.054996673,0.008268836,-0.045630865,-0.03932211,-0.024014452,-0.008473327,-0.034798425,0.00893221,0.01600341,-0.0100874705,0.03823369,-0.007231377,0.045724723,-0.055005804,0.005364433,0.08890209,0.025513569,-0.03823302,-0.0077951076,0.04409275,0.027792351,0.048702978,-0.013502568,0.016447902,0.05669289,0.041610107,-0.054827657,4.857472e-33,0.069129795,0.03215908,-0.0053402185,0.09124332,-0.03883334,0.03940134,-0.025293961,0.053866766,0.004009561,-0.0784161,-0.1128791,-0.08932779,-0.048437733,0.07383194,-0.028918164,0.037909217,0.046426237,-0.030579394,0.048250254,0.009215627,-0.00025024003,0.018400028,-0.0830715,0.003078486,0.0019770043,0.04198477,0.013730884,-0.030733239,0.0704988,-0.010149055,0.06522385,-0.054537684,-0.1135511,-0.017872106,0.03814103,0.033940148,-0.017719418,-0.0024999797,-0.043688886,0.04542427,-0.05290596,0.077712625,-0.029811068,0.018472442,0.06535124,-0.031538606,-0.060761716,0.12343566,0.08599685,0.018009625,0.02799419,0.024153419,0.033912152,0.07575226,-0.060518302,-0.009395444,-0.030031424,0.028810225,0.005080248,0.031644642,0.007879766,0.036232788,-0.0049624597,0.025726864,0.00037377691,0.09378682,-0.08964037,-0.08735747,-0.0066399546,0.044345867,-0.023657897,-0.079751275,0.021107255,0.0585442,0.018008443,-0.0004804729,-0.092155285,-0.054572947,0.05913224,0.018288976,-0.04838017,0.017921306,0.032544542,-0.07168662,-0.079111226,-0.059767846,-0.033153776,-0.011918805,-0.00010812279,0.06483067,0.0027909991,-0.018126218,-0.06864027,0.042268436,-0.017238962,-4.319058e-33,0.08963036,-0.105796576,0.039333668,-0.014857309,-0.11105551,0.020075018,-0.07551657,-0.044575572,-0.011600413,-0.009825136,0.05080836,0.015320481,0.10128356,0.013825761,-0.051243562,-0.08449641,0.027921015,0.12754856,0.07655172,0.012854162,-0.044182874,0.057846684,0.021412324,0.007789553,0.05919689,-0.00751851,0.0045910724,0.0029019613,-0.06562154,0.06116114,-0.0035906266,-0.011517264,-0.024124727,-0.007532316,-0.09211555,0.10210991,-0.045566138,-0.0926903,-0.000844088,0.10869654,-0.053579602,-0.063125156,0.08247108,0.054018397,0.057943325,-0.04719715,-0.07889249,0.0502967,0.06036518,-0.06085838,0.014047664,0.007802004,-0.0071830517,-0.049067102,-0.0004346772,0.032237627,0.028185008,0.0020398921,0.05867064,-0.0705142,-0.023218146,0.054337185,0.010658576,-0.07777909,0.03050825,0.11194719,0.046235498,0.08779569,0.05298377,-0.033885166,0.067856595,0.056184266,0.06809767,0.02919258,0.032822557,0.048444614,0.008577779,-0.00019235455,-0.001626317,-0.07434373,-0.01087773,-0.0074325185,0.05072327,-0.072557986,-0.111806765,-0.09125226,0.054400593,0.008784527,-0.05666465,-0.0023241148,-0.017237026,-0.016937748,-0.029170021,0.0886653,0.11411133,-4.2751843e-08,0.006113491,0.03648824,-0.0706239,-0.030860674,-0.004521935,-0.0006909281,0.01172335,-0.016922416,0.0119449245,0.0031334842,-0.07526764,0.03521062,0.038600713,0.014108694,0.040530708,0.01497359,0.0061659175,-0.0025762308,-0.04336283,-0.018891683,-0.0047157137,-0.0076782056,-0.10955379,-0.01012299,-0.014281468,-0.13680129,0.050462298,0.06195119,0.007180022,-0.014117561,0.03444403,-0.006852779,0.016983071,-0.0032550497,-0.044824522,0.049466744,-0.05636995,-0.040795166,0.013072418,-0.008521016,-0.016292088,-0.09097164,-0.10156802,-0.042196903,-0.064622805,-0.050652932,-0.023868257,0.0032092778,-0.040022567,0.020880342,0.057841107,-0.026458846,0.022492139,0.010989265,-0.014672237,-0.030171506,0.036752254,-0.00614263,-0.03839092,-0.06874473,-0.091348454,0.019705867,0.15159968,0.0033744236 +4.2.3.10,(3R)-Linalyl diphosphate is an intermediate in the reaction,384,0.99999994,-0.09776485,-0.057305176,-0.067154504,-0.022167992,0.031075642,-0.0082449885,-0.041781355,-0.012908609,0.033902053,0.0067901383,0.04434946,-0.009424818,0.0082310205,0.024823911,-0.014572978,0.0059231077,-0.052338537,-0.018430574,0.01722302,-0.0065441793,-0.03136969,0.002996187,0.023852827,-0.021996655,0.0538857,0.081067555,0.054191895,-0.0048261588,0.09564837,-0.052234396,-0.013764902,0.059100453,-0.022598075,-0.12110934,-0.008559989,0.09232711,-0.08714699,-0.05517617,-0.07253474,0.03980299,0.08379719,-0.039162908,0.0021844036,-0.04998414,-0.029602582,0.044270538,0.0022509112,-0.03412548,0.06229644,-0.0075183217,-0.043821868,-0.047594376,-0.010406959,-0.008407333,-0.015585812,-0.056588948,0.00045199634,0.069134794,-0.0066578533,-0.044826113,-0.022068858,0.020084495,-0.068487026,-0.014014051,0.09479899,-0.070304565,0.032303862,-0.0385097,0.0063775345,0.019939939,-0.094178304,-0.07051761,-0.0116470335,-0.087956026,-0.012752418,-0.00573863,0.070538096,-0.027159745,0.06810034,-0.045876496,0.04754355,-0.065599374,-0.03007096,0.028083421,-0.053868145,0.04851252,-0.09031529,-0.014297183,0.028972859,0.012646829,-0.017494544,-0.004118556,-0.052242953,-0.03831759,-0.053361036,0.11430652,0.022463353,-0.012757292,0.0101887,0.023093432,0.037241757,0.07001538,-0.055628076,-0.056029737,-0.057561584,0.053280763,-0.05249885,0.08694518,-0.041687872,0.071585074,-0.018884255,-0.052290842,0.039019033,0.027298367,-0.070979536,0.094599046,0.055073805,-0.09988612,0.032491997,-0.0811086,0.05155843,-0.011305129,0.017965524,0.07571844,-0.032093205,-0.01142623,-0.05093334,-2.8063767e-33,0.044271648,0.050228097,-0.0004496604,0.0074031153,-0.13558012,-0.004537793,-0.049775172,-0.05717394,-0.09736518,0.010888208,-0.008848356,-0.09345325,0.1316266,-0.0062711076,-0.05403608,-0.044289082,0.010896959,0.018084643,0.042582832,-0.02532562,0.022245962,0.045706004,-0.09657322,0.005924302,-0.028513612,0.032196965,-0.03670219,-0.02155773,-0.0073120655,-0.05858996,0.14290105,0.008018899,-0.06389927,0.03167657,0.050441485,-0.050702382,-0.028486267,-0.04822135,0.023195038,0.0077389274,-0.02185128,-0.032089897,0.012357294,0.031962022,0.102800325,-0.062411338,-0.018745147,0.045668405,0.027078247,0.021716192,0.07482272,-0.005094356,0.08375326,-0.02450769,-0.0021819407,0.06351648,-0.0134279225,0.026439022,0.04685785,0.043294936,-0.0037435517,0.02681059,-0.047868293,0.048892442,0.052007604,0.033348173,-0.109861575,-0.021841733,0.0817998,0.060896035,0.012844989,0.02671993,0.08672598,0.040987883,0.028802335,0.04014681,-0.07426069,0.011642171,0.01083536,0.023116123,0.07474172,-0.023027776,0.020970486,0.040618613,-0.092303865,0.012839231,0.023293538,-0.08904504,0.019881379,0.10579684,0.023894176,-0.05001065,-0.055629645,-0.010402137,0.026110653,4.476583e-34,0.14446251,-0.030313151,-0.007869806,-0.05210924,-0.08347716,-0.044983014,0.072956204,-0.07030572,0.0071728514,0.059272274,0.060013372,-0.010688512,0.007787703,-0.020046135,-0.021426389,0.10483349,-0.0033278568,0.04129559,0.015651673,0.0054862075,0.021020532,0.0914674,0.039805453,0.09844945,-0.04562293,-0.03192616,0.043594725,-0.027035829,-0.019902727,0.08876522,-0.035433512,-0.06467989,0.0049470267,0.004634198,0.027281614,-0.0153101245,-0.035271253,-0.012237054,0.0022249469,0.023079224,-0.0033678422,0.044663418,0.05794533,0.04686493,0.057711817,0.030269122,0.00086261873,0.023558302,-0.02358068,-0.06435354,-0.05156948,-0.0031856713,0.022637257,0.041193992,0.06259766,0.053380776,0.03723524,-0.036968183,0.06464791,-0.08178292,0.047204964,-0.061156724,0.05178066,-0.07701634,0.12040387,0.0820673,-0.060654927,0.034367207,0.03878791,3.8009042e-05,0.042567033,0.0006666494,0.10301585,-0.04101107,0.037323687,-0.08879632,-0.011926712,-0.016244447,0.034593817,-0.086239144,-0.06507857,0.026836189,-0.011987778,-0.07991097,-0.0295901,-0.0764498,-0.05464547,0.07161201,0.00333604,-0.09696647,-0.02258811,-0.031728778,0.04336014,0.045824476,0.13242888,-2.2737174e-08,0.011951842,-0.007992386,-0.042032488,-0.026232457,0.0149859805,0.10007558,0.027926201,-0.04345589,0.0041479645,0.07132983,0.0036205316,0.0043486413,0.06936026,-0.058188826,0.11810894,0.02153298,-0.020396082,-0.02068532,-0.06442425,-0.110320315,0.010070307,0.02142384,-0.022936828,0.0062452797,0.01060633,0.0005071482,-0.0026694466,0.020864174,0.00674306,-0.0755705,0.026544003,0.02306766,0.010106134,-0.08676405,-0.0048551573,0.047424063,0.019906081,0.03807617,0.01362649,0.012541552,-0.099772215,-0.009978391,-0.060896132,0.05177097,-0.036157455,0.04155023,-0.017625716,-0.038546577,-0.02068749,-0.05186846,-0.028152062,-0.011917692,0.021332098,-0.0040988605,-0.05182653,-0.0567043,-0.06681986,-0.0016581928,0.005530056,-0.026090275,0.051619582,0.042951386,0.08139273,-0.02101555 +4.2.3.11,Both cis- and trans- isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction,384,1.0,-0.08128492,-0.05346107,0.026942972,-0.012336028,-0.027062792,0.020619633,0.0031837772,0.0036407006,0.067127,-0.056308314,0.046797592,-0.08425787,0.025856553,-0.06601225,-0.03753424,-0.08157956,-0.04913308,0.017175475,0.026143193,0.027280321,0.06327412,-0.0080876965,0.002666382,0.03294596,0.008234288,0.021574095,0.06931823,-0.026152428,0.10810557,-0.042626947,-0.024846083,-0.024216073,-0.06201575,-0.114062406,-0.033083342,0.05618742,-0.053014696,-0.06096738,0.030747358,0.01887024,0.035461314,-0.107217565,0.014563289,-0.010198571,-0.026307188,0.0118405735,0.012060273,-0.028970333,0.017836526,-0.02851717,0.01790347,-0.05734873,-0.0721885,0.035749227,-0.019853244,-0.009116387,-0.032606155,0.05087203,0.0056320513,-0.053660497,0.06802358,0.06616616,-0.027964875,-0.03829429,0.04122899,-0.0038213497,0.013517186,0.0071669756,0.058032986,-0.02793702,-0.079773456,-0.04691201,-0.014314748,-0.0010869936,-0.020749157,-0.015752923,0.038796235,0.023456138,-0.006725581,-0.05461231,0.018011527,0.010712365,0.03865533,-0.011822065,-0.054454148,0.001690605,0.014595502,0.019119408,0.027616601,-0.049831353,-0.004321311,0.06426528,-0.022516813,-0.073085114,-0.017127601,0.09733204,-0.011167609,0.07986914,0.103372745,-0.013135317,0.038232595,0.12599017,-0.12789394,-0.05660459,-0.048462547,0.022010641,-0.10219987,0.07399122,-0.019008802,0.025131414,-0.028460152,-0.101851374,0.0395467,0.017442403,-0.08787434,0.087430485,-0.018368129,-0.07655009,-0.0019859616,-0.03779461,-0.027094627,0.004434082,0.059102617,0.04905089,0.0010371419,0.0126309125,-0.034486346,-1.7213127e-33,0.048346996,0.010269068,0.021302588,0.082663454,-0.11803726,0.0020127958,-0.06418489,-0.0642026,-0.112631515,-0.066638686,-0.07766126,-0.095588095,0.025897963,-0.016372958,-0.030975828,-0.037659243,0.029322201,0.018737273,0.009388932,-0.08161302,0.01460281,0.1366749,-0.033693668,0.011958489,0.001547215,0.029088164,0.037823536,-0.039179754,0.017970106,-0.055580877,0.037818335,-0.036303524,-0.028869372,0.06041339,0.07193145,0.052902687,-0.03390143,0.014333528,0.012799704,0.030555818,0.037332416,-0.03843946,0.034626346,0.00411557,0.09088528,-0.0025150399,-0.032034058,0.0038209388,0.07668274,-0.010886449,0.015457386,0.075789094,-0.03368966,0.0031520743,-0.044771448,0.031177899,0.01276584,-0.012996502,-0.037765436,0.014662787,-0.04634856,0.064071454,-0.018704118,0.01707093,0.042171456,0.101001814,-0.13969672,0.02547058,0.06927279,0.041626144,-0.080253534,0.012630712,0.1373811,0.079835184,0.060836308,0.06418218,-0.092439026,-0.058128808,-0.054452788,0.023114698,-0.08813438,0.014361553,0.028899925,0.087393686,-0.047467798,-0.040257335,-0.0006925647,0.0054829493,0.07036413,0.13384172,-0.010761639,0.003643926,-0.117870115,-0.009599297,-0.010586321,-3.831779e-34,0.1112362,-0.066048995,-0.032533556,-0.028466195,-0.03400023,-0.046991386,0.030696783,-0.033134162,0.015462983,0.030857662,0.08408539,0.009319969,-0.011650947,-0.046281777,-0.058168825,0.026422873,0.062482018,0.04247589,-0.0444889,0.02637621,0.008614446,0.029640839,0.022746293,0.091404684,-0.013336819,-0.0015557766,0.111234024,0.007657678,0.039402843,0.1003862,0.029811034,-0.06541549,0.033011552,-0.0095677385,-0.035639133,-0.0042624758,-0.025541723,0.008370372,-0.028216898,0.035004262,0.01710888,-0.06668195,0.0404908,-0.028464915,0.058647264,0.0004521488,0.0051536257,-0.05317728,-0.091069184,-0.028005537,0.042062387,-0.067028046,0.04170783,0.002768052,0.008222553,-0.016580615,-0.021842653,0.013971026,0.046544734,-0.013459096,0.07749874,0.008741695,0.066349626,-0.11715231,0.046550762,0.0044511436,-0.06754159,0.017538814,-0.008949828,0.006859547,0.08888092,-0.039594978,0.06485443,-0.021648875,0.10036857,-0.08742684,-0.035276342,-0.06101272,0.009189386,-0.07691864,-0.06085457,0.021168996,0.029427424,-0.049254056,-0.016401336,0.04357773,-0.020340098,0.0908379,0.021416742,-0.0496018,-0.03750219,-0.034897618,-0.03195835,0.025094721,0.13348338,-2.7783459e-08,0.023209263,0.012756601,-0.024913449,0.044632588,-0.08507272,0.06479954,0.008500351,0.0274376,-0.030037079,0.0076891426,-0.001050155,-0.02442259,0.023030026,-0.063543595,0.07012244,0.013836808,0.012827506,0.053853326,-0.06136346,-0.13505696,-0.063754156,-0.0035612495,-0.013714414,-0.022931047,-0.016871845,-0.003851201,0.061740436,0.029840834,-0.006759366,-0.08807708,0.084328935,-0.019153763,-0.016830536,-0.015011207,0.072527885,0.079511896,0.010703161,0.03308013,0.030213313,0.06287678,-0.019800276,-0.0015278263,-0.05290916,0.055686474,0.03266116,0.06194258,-0.0179638,0.041228063,-0.003407479,-0.005177249,0.011985341,-0.0032497342,-0.003082721,-0.041715253,-0.03875526,-0.0076185702,-0.036955852,0.01570314,-0.06626455,-0.018832814,0.029018568,-0.0067501394,0.12357633,-0.016456852 +4.2.3.12,"Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I) [3].",384,1.0,-0.05239234,-0.029693382,-0.07902015,-0.00013761532,0.068120204,-0.016810019,0.0039713085,0.05009228,-0.010172655,-0.021331925,0.0132511845,-0.047286402,-0.048722666,-0.031168556,-0.014804595,-0.037766557,-0.013868708,-0.015016219,0.08874689,-0.07781281,0.01605949,-0.005560027,-0.028633468,-0.005670821,0.021726282,0.0293963,0.08366753,-0.024656754,-0.0002347181,0.03907754,-0.037334375,-0.022850137,0.025584724,-0.10148046,0.017285159,0.12388178,-0.09376939,-0.013073618,-0.025488893,-0.03280742,0.0027005742,0.014530585,-0.026430707,-0.04516336,0.03272635,-0.057300985,-0.00824576,0.048308108,-0.020245137,0.023014514,0.026540443,0.0013876144,-0.02034069,0.060822394,0.047665745,-0.020544909,-0.087605536,-0.014430498,0.039999682,0.018968828,-0.015586897,-0.009335042,-0.013557686,-0.05742754,0.14144102,-0.022072393,0.040572505,-0.06480082,0.031721395,-0.0634816,-0.07932966,-0.0070094583,-0.015365173,-0.011080889,-0.10231578,0.023619702,-0.0016516042,-0.018884957,0.014981746,0.041814663,0.068694584,0.00929282,0.060324818,0.06446813,0.06351446,-0.053082976,-0.058376934,0.06515691,0.0021849677,0.06527379,0.08399987,0.05962083,0.04697856,0.02426511,-0.027960913,0.024756268,-0.07892091,0.03548773,0.007008007,-0.041386977,-0.012748507,0.09951675,-0.036224343,-0.06438128,-0.061423823,0.07170796,-0.052338682,0.08728514,0.09422723,0.012822913,0.021698931,-0.022841005,0.00893394,0.0096803745,-0.016965028,0.14258145,-0.02555098,-0.06135212,-0.054460842,0.015917746,0.04171443,-0.025303228,-0.0033905564,0.0517626,-0.0075666276,0.03609907,-0.02550762,3.3988174e-33,0.021958344,0.06462616,-0.0071925274,0.021474151,0.034783788,0.067262895,-0.028331371,0.030553758,0.005820167,0.011691994,-0.05255749,-0.070795186,0.032068394,-0.0115728965,-0.06500271,-0.026880655,-0.040008638,-0.005653617,0.07152769,-0.01735055,-0.020752009,0.0487201,-0.004479205,-0.02256028,0.035720345,0.10362725,-0.11261102,-0.054920368,0.10661317,0.00080103223,0.019817935,-0.10786403,-0.13343044,0.05995696,0.034103762,-0.07649627,-0.029106922,-0.07633041,-0.025948204,0.07519698,-0.0632069,-0.049682844,-0.024127439,-0.025046196,0.0700048,-0.0770265,-0.028877305,0.036886085,0.01826845,0.042505603,0.061834395,0.0008231619,0.04353211,-0.059076678,-0.10749239,-0.010380013,-0.06945576,0.02756081,0.07287918,0.075462714,0.05239242,0.066913545,-0.033859458,0.06408736,-0.009163922,-0.006587996,-0.05571922,-0.110755295,-0.0368523,0.049157053,-0.05330065,-0.0065446286,0.09294946,-0.024151575,0.006013186,-0.074439146,-0.03993681,0.025040342,0.046467174,0.015533561,-0.04709119,0.02705583,0.032220095,-0.014376647,0.0049540782,0.0046314416,-0.04174085,-0.066439115,9.3849754e-05,0.027968489,0.016825581,-0.022645054,-0.11474078,0.03133356,0.027541684,-3.8174106e-33,0.08907821,-0.059630644,0.006405079,-0.14737612,-0.04639284,0.03552585,0.07248479,-0.068757236,0.08190796,-0.057855077,0.09995692,-0.014122904,0.027479002,-0.042932555,0.031473905,-0.009626119,0.0050171213,0.11654343,-0.06535905,-0.051948167,0.056544688,0.013434813,0.020247495,0.03367154,0.029832618,0.020796211,0.060901213,0.033434607,0.089256644,0.08144974,-0.007864288,0.049073562,-0.05124213,-0.03008065,0.00715977,0.10469647,-0.067612484,-0.011961369,0.06558581,0.057773914,0.03142369,0.07718407,0.020305825,0.039259832,0.017204849,0.083970614,-0.08128138,0.072335415,0.01038219,-0.07093969,0.04621861,0.03827222,-0.08625132,0.023243306,0.053544775,0.0062145777,0.0067236954,-0.042470794,-0.00014210693,-0.029713824,0.0032156776,-0.0015659054,0.024909949,-0.0011394444,0.03014625,0.044254825,0.026913999,0.040513996,0.06846187,0.039766524,0.046328068,-0.0141654,-0.025364859,-6.83214e-05,-0.014836642,0.009136535,0.034170717,-0.0030372029,0.076127954,-0.12006275,0.042981442,0.03001287,0.055365503,-0.0465842,0.019902984,-0.11268534,-0.048713334,0.12555394,0.038266603,0.0021767295,-0.022209886,-0.06112944,-0.041354697,0.040140983,0.049034633,-4.0476625e-08,0.04714003,-0.07641606,0.052715715,-0.07398449,0.038345568,0.051511146,0.041826505,0.01818026,-0.028344814,-0.04489548,0.019028723,-0.010009916,0.0022622466,-0.06285572,0.04535861,0.014188504,-0.028283546,0.064415574,-0.038337804,-0.03509875,-0.005500827,-0.04407155,-0.08031839,0.032747895,0.0031161136,-0.05929966,0.0021652959,-0.00037006033,0.011867838,-0.012438991,0.003222975,-0.0030260673,0.007400753,0.015173901,0.0070567974,0.011695362,-0.034172777,0.027113793,-0.06959386,-0.08013265,-0.106356956,-0.0382245,-0.038799156,-0.042678326,-0.050821118,-0.04070794,-0.0004282824,0.028510632,-0.01034725,0.083374396,0.02037625,-0.041801155,0.00188544,-0.017853923,-0.011852959,-0.034051035,-0.020123236,-0.08315254,-0.05914485,-0.11750828,0.016017174,0.041358758,0.089425944,-0.04870217 +4.2.3.13,The sesquiterpenoid (+)-delta-cadinene is an intermediate in phytoalexin biosynthesis. Mg2+ is required for activity.,384,1.0,-0.023000699,-0.07165622,0.0068836813,0.04146677,-0.03081625,0.008559089,-0.020609349,0.033332516,0.05692419,-0.033728234,0.100579314,-0.03710793,0.023205293,-0.013063849,0.007152241,-0.027693506,0.033292826,0.08214122,-0.031268626,-0.025550373,0.06857309,0.046205647,-0.04755328,0.0041462905,0.044911817,-0.014372687,0.0030727226,-0.023932127,0.095437646,-0.0022224477,-0.034225855,-0.00054378674,0.03597888,-0.07116954,0.00057901733,0.015651518,-0.08416673,-0.021787707,0.075748,-0.02490072,0.04307732,0.009188213,0.07726541,-0.03241782,-0.05843026,-0.08377348,0.027125778,-0.10219218,0.027230099,0.016779521,-0.013560205,-0.013156724,-0.11130734,0.03925245,0.031863187,-0.027786527,-0.055727065,0.019136373,0.0049481806,-0.02209506,-0.00863033,0.020542532,0.010125147,-0.0072899857,-0.0022363197,-0.036923215,-0.035579193,0.008817959,0.0244374,-0.014594773,-0.038177084,-0.06501079,-0.013181324,0.037318513,-0.027451439,0.047645617,0.0151224295,0.025971612,0.043552503,-0.046435807,0.07699576,0.025097165,0.1073212,0.13996959,0.03920843,0.050518382,-0.016636055,0.003644304,0.040579256,0.050254058,0.14385323,0.05828942,-0.004458382,-0.01250401,-0.06473717,0.05300067,-0.016027177,0.05259882,-0.07631923,-0.005361341,0.011396499,0.07324204,-0.11868473,0.003754477,0.048797853,0.004159487,-0.05817483,-0.06351936,0.028340537,-0.033972908,0.07936427,-0.07843193,0.010521553,0.010848276,0.011989414,0.08591838,0.0038020231,-0.024194214,0.0718581,-0.030659614,0.03782482,-0.032230835,-0.007009025,-0.026354983,-0.044866122,-0.02030851,0.003898609,8.626512e-34,0.031980246,0.027816873,0.016672064,0.05500412,-0.011837929,-0.06673355,-0.05849819,-0.0014473737,-0.062094666,-0.08341273,-0.15921146,-0.069794595,-0.04262654,0.085180394,0.022623485,-0.021245025,-0.057338364,-0.08843588,0.14216019,-0.025990672,0.02757618,-0.019272566,0.0032598847,-0.009439228,0.03252253,0.021372717,-0.0092557855,-0.007662499,-0.018276589,0.014620256,0.0037120883,-0.07169807,-0.06663851,-0.0020569384,0.0050672516,-0.049383413,0.052853856,-0.03619598,-0.12679118,-0.020646933,-0.0826511,0.067776665,-0.09019124,0.013897909,0.079735614,-0.043715317,-0.05041782,0.04678436,0.09697251,0.04644985,-0.00038231423,0.01132888,0.121117495,0.015215328,-0.07171952,0.0009502874,-0.026019879,-0.010104601,-0.0049084416,0.084734544,0.03030448,0.008117376,0.004741309,0.027738545,0.084324695,0.13487199,-0.099789575,-0.066769734,0.037007805,-0.023951543,-0.014443934,-0.0720204,0.029279307,-0.01789449,0.046409186,-0.004283551,-0.054571576,0.012805541,-0.010284512,0.017013593,-0.018688241,-0.04938948,0.017962072,0.037396867,-0.055426206,-0.03390711,0.013534692,0.0011314717,0.045288555,-0.0017968081,0.00082169106,-0.030696942,-0.047586896,0.048156958,-0.052708108,-1.098587e-33,0.00045210146,-0.023884173,0.031995483,-0.009789374,-0.07164971,0.030801512,0.020619223,-0.035493206,0.04340852,0.06413554,0.039048493,0.045778103,0.024105512,-0.012832759,-0.019517543,-0.0253189,-0.06780104,0.07246042,-0.04902175,-0.019115394,0.0017844441,0.063563004,0.0041228477,0.07712284,0.0580461,0.069793575,0.01981387,0.011988246,-0.033445228,0.062968895,0.03097383,0.03155044,-0.0034815145,0.027387187,-0.09875824,0.05753087,0.0066666985,-0.0017072251,-0.05307449,0.08188442,0.029253658,0.019667486,0.037595853,0.10280197,0.09024148,-0.01800977,-0.09830487,0.0793627,-0.021011518,-0.07290657,0.029841535,0.028374638,-0.03477152,0.031679366,0.030433986,-0.014314683,0.02788132,0.015280768,0.017969137,-0.06504997,-0.019837493,-0.025396686,-0.02643544,-0.063471444,0.08406245,0.028065369,0.0035045326,0.03421589,0.033909805,0.0068676816,0.079511814,0.05124753,0.026465116,-0.04880918,-0.020153485,0.009005164,0.0062410627,-0.08328019,0.05644421,0.02508104,-0.031440813,0.015729504,0.052658897,-0.039123993,-0.029694462,-0.09334075,-0.014469392,0.13826294,0.040679,0.018118698,-0.042449508,-0.07769903,-0.07119623,0.08005035,0.050694942,-3.12315e-08,0.03011173,0.0009907993,-0.057312485,-0.019608386,-0.0020164116,0.015048517,-0.052886326,-0.01925749,0.07900722,0.031638116,-0.0026887704,-0.021285243,0.007590993,0.0036930188,0.03467144,0.045655157,0.059310306,0.006228934,-0.04844008,-0.02751203,-0.017984448,-0.04146941,-0.08772406,0.010502658,0.028175568,-0.16777511,-0.082297,0.0378535,0.00394984,-0.020548474,0.012168439,-0.027138753,0.01735362,0.0036721525,-0.07198634,0.046767063,-0.036606304,-0.06108519,0.035462987,-0.012060362,-0.08560114,-0.15042728,0.014623486,-0.010073861,0.0017374835,0.046201315,0.052174702,0.010091722,-0.03221083,0.014178899,0.008348114,-0.08216634,0.01050041,-0.04868113,-0.100085475,-0.04187275,-0.022707375,0.036434833,-0.05425687,-0.103134625,-0.039070282,0.061025865,0.12876222,-0.04461983 +4.2.3.14,A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor. A mixture of alpha and beta-pinene is produced.,384,0.99999994,-0.033312485,-0.07342452,-0.034892853,0.058603138,0.017531335,-0.01802353,-0.009551181,0.008809036,-0.024580771,0.036093183,0.014258711,-0.0040869857,0.0098627005,0.023592362,-0.079680756,-0.00018667869,-0.043258533,0.037286732,0.036946837,0.019581692,0.0935996,0.029020872,-0.03944049,0.0070933434,0.017235737,-0.0014643567,-0.057854563,-0.043478716,0.057423122,0.0021413928,-0.030003183,0.06255578,0.109613456,-0.012063186,-0.01349906,0.06949223,-0.003186619,-0.016559888,-0.01636292,0.0078573255,0.056645118,0.07404125,0.07497983,-0.061607115,-0.0018969155,-0.023095429,0.04567369,-0.07857237,-0.04719867,0.026460826,-0.01781489,-0.060165823,-0.0717908,0.047245122,0.062303968,-0.0037662636,-0.051211193,-0.065340474,-0.034219638,0.009187701,0.021173023,0.05029011,-0.059790514,-0.022243345,0.035743,-0.008637428,-0.075473435,-0.019897966,-0.020082852,-0.057308555,-0.022341333,-0.080132626,-0.13825703,-0.06616891,-0.037758797,0.052326676,0.023896556,-0.014391167,0.024396854,-0.011192172,0.024354108,0.018189399,0.056949962,0.05315727,0.04642766,0.04749927,0.06416999,0.032407284,0.0014601919,-0.023477778,0.055349324,0.037922196,0.051325466,0.014872085,-0.03653321,0.084460795,0.013702331,-0.012839073,0.0008806236,0.019330552,-0.017345013,0.031677432,-0.024152612,-0.052958995,-0.09688505,-0.0042488305,0.0048339604,0.07897752,0.036662232,0.023555018,0.014849082,0.029387478,0.019192595,0.051224582,0.0052649085,0.047728393,0.034289293,-0.07667785,-0.021648519,0.024956055,0.063154094,0.02421472,-0.021655971,0.07102529,-0.016866008,0.0378842,-0.044574067,2.476969e-33,0.024839815,0.090057544,0.023874816,-0.011418615,-0.024757663,0.013235129,-0.0961224,-0.028485477,0.022399912,-0.061984688,-0.06651714,-0.00024637685,0.030241165,0.038214985,0.034666725,-0.038603343,-0.020931697,-0.013374066,0.13035035,0.016063789,-0.039444655,0.05219637,-0.057858545,-0.012070487,0.03698923,0.09198104,0.03457071,-0.06094499,0.06712213,-0.0059818286,0.0014791302,-0.102882594,-0.062163886,0.03950738,0.029544052,-0.071988836,-0.04646215,-0.05371241,-0.07283282,0.02278068,-0.07801095,0.0137440385,-0.07892269,0.038514614,0.092867516,-0.10936102,-0.050802357,0.04753409,-0.017146315,0.04627837,0.008755676,0.050434347,0.0091756275,0.022324517,-0.106558815,0.10662304,0.010830916,0.012064671,0.022240633,0.04435222,0.008772465,0.012510173,-0.038833335,0.048049614,-0.011839361,0.047317464,-0.060559656,-0.08907935,-0.024484608,0.11239777,-0.034802344,-0.09250071,0.028915897,0.0071838764,0.019262375,-0.013671925,0.0009278646,0.015599535,0.064741366,0.0067300317,-0.05254336,0.012991657,-0.022699187,-0.02131352,-0.085755065,-0.08912557,-0.029241946,0.028593583,0.0029012428,0.030962594,0.05274741,0.01772414,-0.0441823,0.023131885,0.0044002803,-3.4040454e-33,0.03919137,-0.060240537,0.0715944,-0.07905969,-0.09043446,0.025112968,-0.015367767,-0.15576565,0.035924952,-0.015589099,0.034335624,0.0146717625,0.042556945,-0.009999812,-0.022471275,-0.052074805,0.016253099,0.13432853,0.002279733,-0.040303227,0.058856264,0.09806491,0.035926707,-0.008909422,0.00972789,0.0054420815,-0.04271381,0.09308507,0.009137962,0.03332625,0.009760937,-0.028581573,-0.008085236,-0.10290866,-0.05836456,0.06902586,0.015647138,-0.0064346488,-0.05137196,0.014255383,-0.0072537865,0.020566925,0.05267517,0.12379929,0.08677279,0.005830496,-0.1138164,0.054262456,0.11356206,-0.024497392,0.00047476863,-0.01971074,-0.067196816,-0.029142246,-0.008745728,-0.057591517,0.032669116,-0.001127446,0.001115525,-0.047104113,-0.0148646785,-0.08132328,0.03941572,-0.058724176,0.036700767,0.0068666586,0.035775185,0.05077841,0.038653124,0.03473176,0.09945247,0.08723677,0.031505324,-0.0033551282,-0.01610975,0.037036773,-0.045258537,-0.08558372,-0.00387879,-0.07194059,0.009573638,0.09810227,0.0068929996,0.0006928177,-0.04256192,-0.123960316,0.028256863,0.13986257,-0.008066831,-0.02447952,-0.06005465,-0.030728236,-0.04638375,0.096358865,0.023981577,-3.7632617e-08,-0.047989316,-0.013378156,-0.01981574,-0.077534795,-0.024899254,0.017778197,-0.0482043,-0.06542845,0.047025308,-0.07175113,0.018996105,0.033087548,-0.009757088,0.044372033,0.04952653,-0.017882973,0.0012284772,-0.020432396,-0.04306021,-0.012524228,0.022197373,-0.03312692,-0.065117344,0.07655661,-0.07584478,-0.1556269,0.024721008,0.061253477,-0.053564716,-0.015298373,0.02935813,0.07698863,0.051783,0.020633725,-0.07987226,0.03277276,-0.006966158,0.019030694,-0.024272174,-0.058899373,-0.040453702,-0.054402906,0.007184835,-0.014852187,-0.050983608,-0.044733178,0.025042593,-0.031925637,0.05018367,0.029900203,0.05012373,-0.023072809,-0.008719788,-0.043535996,-0.0404029,-0.024665397,-0.0066444953,-0.04666483,0.029689187,-0.10165726,0.03119691,-0.008954399,0.16951281,-0.016431723 +4.2.3.15,A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.,384,1.0,-0.040041886,-0.056231663,-0.043637775,0.044920024,0.01716841,-0.034970943,-0.00777716,0.018756371,-0.04838753,0.04017389,0.017210586,-0.0114716105,0.01787813,0.017403083,-0.060498625,0.00916136,-0.028600052,0.031006794,0.028281849,0.0062191333,0.09723648,0.014532832,-0.027208026,-0.01715426,0.012963323,0.027998844,-0.053294882,-0.03935781,0.05242233,0.0032823698,-0.062873274,0.07431915,0.10976029,-0.035280988,0.010355423,0.07483157,-0.007278698,0.004047895,-0.037380293,-0.0249556,0.06263274,0.07303,0.08717738,-0.06424585,-0.011598237,-0.0402145,0.057301097,-0.09485892,-0.035613995,0.038992472,-0.011257846,-0.036335893,-0.055765416,0.06506028,0.06558553,-0.0030689086,-0.06651608,-0.036941957,-0.042355247,0.0023587558,0.005192295,0.03083402,-0.042724352,-0.017968578,0.04154339,-0.013352491,-0.062607355,-0.028895004,-0.027507856,-0.052224394,-0.016685827,-0.081624664,-0.12225152,-0.06366024,-0.033115126,0.06748979,0.035272468,-0.023875212,0.029120354,0.0014137479,0.014756371,0.02119633,0.08111129,0.04700168,0.03960102,0.041374717,0.06339237,0.017884813,-0.005494982,-0.024287982,0.06424428,0.024161285,0.058547873,0.017845254,-0.04086073,0.0819667,0.0031710796,-0.003963928,-0.013764517,0.015930494,-0.0034256699,0.034741543,-0.04427745,-0.025224404,-0.07918493,-0.013657236,0.00027568775,0.0878363,0.030697186,0.020886652,0.0262316,0.035802584,0.033413157,0.04314281,0.0056308564,0.035857864,0.0318455,-0.082254305,-0.019141678,0.020901432,0.07447268,0.022025019,-0.034621056,0.052018434,-0.0022811436,0.03632109,-0.052478425,3.211236e-33,0.0140236905,0.07347126,0.036427695,-0.028988106,-0.020945622,-0.00065776706,-0.08084389,-0.007040057,0.01333737,-0.07100408,-0.0613905,-0.0031910795,0.045684747,0.04177407,-0.0018800491,-0.035850305,-0.018473445,-0.02491793,0.1329101,0.016150566,-0.009819175,0.048450787,-0.038404413,-0.010521322,0.031900547,0.1084871,0.03715461,-0.06321904,0.06646231,0.008044728,-0.015169726,-0.12865388,-0.0547162,0.032673288,0.0261033,-0.059819743,-0.03869413,-0.052252013,-0.07147227,0.006998586,-0.10460024,0.026716502,-0.0983295,0.02542318,0.095372,-0.11057546,-0.050012052,0.042886056,-0.029326482,0.05159242,0.015128091,0.03073199,0.014891495,0.031117283,-0.08971418,0.124993406,0.0150677925,0.006336249,0.016851775,0.03911366,0.010935989,0.007342592,-0.03579534,0.067363404,0.003745206,0.046272375,-0.06540161,-0.09322384,-0.016675128,0.14110798,-0.046942003,-0.0754595,0.030667726,0.027951347,0.033317015,-0.02531096,0.0051207063,0.0026446886,0.06565221,0.02363797,-0.037267767,-0.0027400488,-0.015057335,-0.013897363,-0.09642293,-0.09839979,-0.049836785,0.016343711,-0.010392644,0.015631288,0.049153607,0.025133116,-0.039677773,0.024063958,-0.015933296,-4.1595907e-33,0.0567842,-0.03714503,0.078256406,-0.081695184,-0.09221672,0.028818194,-0.0070291306,-0.13980243,0.026234763,-0.017519064,0.038732793,0.020529786,0.039285712,-0.008323694,-0.01859924,-0.044064548,-0.0007421717,0.13113876,0.0005827548,-0.036568683,0.04080422,0.09661249,0.03626301,-0.01540962,0.011967478,-0.0055172383,-0.060243294,0.07858859,-0.0035327254,0.032865524,-0.0231905,-0.01866666,-0.017610865,-0.11052917,-0.046775986,0.050961677,-0.0012829493,-0.013677722,-0.053215194,0.014393718,-0.006948557,0.030688815,0.06602904,0.11116305,0.07610226,0.0027920243,-0.13481192,0.079013936,0.1264115,-0.040341485,-0.012124247,-0.014985377,-0.077425316,-0.040333975,0.013383922,-0.059117984,0.0417351,-0.0025453563,-0.009250118,-0.028705284,-0.026892506,-0.09034188,0.04774707,-0.044015106,0.039416876,0.03536746,0.045193877,0.050276514,0.022327533,0.040509954,0.10644992,0.070704155,0.03580827,-0.008675378,-0.014772358,0.034619972,-0.049681593,-0.06739014,0.0069909426,-0.060776766,0.020604946,0.08168192,0.014923139,-0.0066028074,-0.030837161,-0.12538227,0.016660348,0.122050785,-0.005732286,-0.020614035,-0.07182606,-0.047738124,-0.047907088,0.076066494,0.0051392196,-3.678248e-08,-0.046407077,-0.014580604,-0.016795471,-0.08838696,-0.018061416,0.04394905,-0.07158314,-0.060376808,0.063978925,-0.05022196,0.04514717,0.027365152,-0.00797818,0.05051757,0.044198524,-0.018882293,0.011151958,-0.02657107,-0.04585499,-0.018655496,0.0041800616,-0.03920055,-0.07947262,0.07367183,-0.05578927,-0.13892555,0.021207169,0.05313232,-0.041068047,-0.018164178,0.0027223784,0.06792411,0.065986365,0.025510846,-0.07938715,0.028480096,-0.008115356,0.017698389,-0.030336726,-0.058321603,-0.0396984,-0.049204066,0.01909218,-0.019980388,-0.049085904,-0.0330544,0.039141364,-0.018258544,0.030036623,0.026354412,0.049015716,-0.039508868,-0.010964231,-0.05273582,-0.037411977,-0.016000746,-0.0014924603,-0.046989564,0.023398794,-0.0954587,0.04009036,0.0063033476,0.1559707,-0.018217815 +4.2.3.16,A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.,384,1.0,-0.040041886,-0.056231663,-0.043637775,0.044920024,0.01716841,-0.034970943,-0.00777716,0.018756371,-0.04838753,0.04017389,0.017210586,-0.0114716105,0.01787813,0.017403083,-0.060498625,0.00916136,-0.028600052,0.031006794,0.028281849,0.0062191333,0.09723648,0.014532832,-0.027208026,-0.01715426,0.012963323,0.027998844,-0.053294882,-0.03935781,0.05242233,0.0032823698,-0.062873274,0.07431915,0.10976029,-0.035280988,0.010355423,0.07483157,-0.007278698,0.004047895,-0.037380293,-0.0249556,0.06263274,0.07303,0.08717738,-0.06424585,-0.011598237,-0.0402145,0.057301097,-0.09485892,-0.035613995,0.038992472,-0.011257846,-0.036335893,-0.055765416,0.06506028,0.06558553,-0.0030689086,-0.06651608,-0.036941957,-0.042355247,0.0023587558,0.005192295,0.03083402,-0.042724352,-0.017968578,0.04154339,-0.013352491,-0.062607355,-0.028895004,-0.027507856,-0.052224394,-0.016685827,-0.081624664,-0.12225152,-0.06366024,-0.033115126,0.06748979,0.035272468,-0.023875212,0.029120354,0.0014137479,0.014756371,0.02119633,0.08111129,0.04700168,0.03960102,0.041374717,0.06339237,0.017884813,-0.005494982,-0.024287982,0.06424428,0.024161285,0.058547873,0.017845254,-0.04086073,0.0819667,0.0031710796,-0.003963928,-0.013764517,0.015930494,-0.0034256699,0.034741543,-0.04427745,-0.025224404,-0.07918493,-0.013657236,0.00027568775,0.0878363,0.030697186,0.020886652,0.0262316,0.035802584,0.033413157,0.04314281,0.0056308564,0.035857864,0.0318455,-0.082254305,-0.019141678,0.020901432,0.07447268,0.022025019,-0.034621056,0.052018434,-0.0022811436,0.03632109,-0.052478425,3.211236e-33,0.0140236905,0.07347126,0.036427695,-0.028988106,-0.020945622,-0.00065776706,-0.08084389,-0.007040057,0.01333737,-0.07100408,-0.0613905,-0.0031910795,0.045684747,0.04177407,-0.0018800491,-0.035850305,-0.018473445,-0.02491793,0.1329101,0.016150566,-0.009819175,0.048450787,-0.038404413,-0.010521322,0.031900547,0.1084871,0.03715461,-0.06321904,0.06646231,0.008044728,-0.015169726,-0.12865388,-0.0547162,0.032673288,0.0261033,-0.059819743,-0.03869413,-0.052252013,-0.07147227,0.006998586,-0.10460024,0.026716502,-0.0983295,0.02542318,0.095372,-0.11057546,-0.050012052,0.042886056,-0.029326482,0.05159242,0.015128091,0.03073199,0.014891495,0.031117283,-0.08971418,0.124993406,0.0150677925,0.006336249,0.016851775,0.03911366,0.010935989,0.007342592,-0.03579534,0.067363404,0.003745206,0.046272375,-0.06540161,-0.09322384,-0.016675128,0.14110798,-0.046942003,-0.0754595,0.030667726,0.027951347,0.033317015,-0.02531096,0.0051207063,0.0026446886,0.06565221,0.02363797,-0.037267767,-0.0027400488,-0.015057335,-0.013897363,-0.09642293,-0.09839979,-0.049836785,0.016343711,-0.010392644,0.015631288,0.049153607,0.025133116,-0.039677773,0.024063958,-0.015933296,-4.1595907e-33,0.0567842,-0.03714503,0.078256406,-0.081695184,-0.09221672,0.028818194,-0.0070291306,-0.13980243,0.026234763,-0.017519064,0.038732793,0.020529786,0.039285712,-0.008323694,-0.01859924,-0.044064548,-0.0007421717,0.13113876,0.0005827548,-0.036568683,0.04080422,0.09661249,0.03626301,-0.01540962,0.011967478,-0.0055172383,-0.060243294,0.07858859,-0.0035327254,0.032865524,-0.0231905,-0.01866666,-0.017610865,-0.11052917,-0.046775986,0.050961677,-0.0012829493,-0.013677722,-0.053215194,0.014393718,-0.006948557,0.030688815,0.06602904,0.11116305,0.07610226,0.0027920243,-0.13481192,0.079013936,0.1264115,-0.040341485,-0.012124247,-0.014985377,-0.077425316,-0.040333975,0.013383922,-0.059117984,0.0417351,-0.0025453563,-0.009250118,-0.028705284,-0.026892506,-0.09034188,0.04774707,-0.044015106,0.039416876,0.03536746,0.045193877,0.050276514,0.022327533,0.040509954,0.10644992,0.070704155,0.03580827,-0.008675378,-0.014772358,0.034619972,-0.049681593,-0.06739014,0.0069909426,-0.060776766,0.020604946,0.08168192,0.014923139,-0.0066028074,-0.030837161,-0.12538227,0.016660348,0.122050785,-0.005732286,-0.020614035,-0.07182606,-0.047738124,-0.047907088,0.076066494,0.0051392196,-3.678248e-08,-0.046407077,-0.014580604,-0.016795471,-0.08838696,-0.018061416,0.04394905,-0.07158314,-0.060376808,0.063978925,-0.05022196,0.04514717,0.027365152,-0.00797818,0.05051757,0.044198524,-0.018882293,0.011151958,-0.02657107,-0.04585499,-0.018655496,0.0041800616,-0.03920055,-0.07947262,0.07367183,-0.05578927,-0.13892555,0.021207169,0.05313232,-0.041068047,-0.018164178,0.0027223784,0.06792411,0.065986365,0.025510846,-0.07938715,0.028480096,-0.008115356,0.017698389,-0.030336726,-0.058321603,-0.0396984,-0.049204066,0.01909218,-0.019980388,-0.049085904,-0.0330544,0.039141364,-0.018258544,0.030036623,0.026354412,0.049015716,-0.039508868,-0.010964231,-0.05273582,-0.037411977,-0.016000746,-0.0014924603,-0.046989564,0.023398794,-0.0954587,0.04009036,0.0063033476,0.1559707,-0.018217815 +4.2.3.17,"This is the committed step in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The cyclization involves a 1,5-hydride shift. ",384,1.0,0.012530151,0.029481413,-0.028725903,-0.042712282,-0.03365353,-0.05392835,0.027428566,0.039883688,0.079610854,0.029654067,0.05105188,0.06023966,0.045961544,-0.0680122,-0.035214886,0.0413897,-0.09506173,0.03449712,-0.027499326,0.02168745,0.09125762,0.020666257,0.014330607,0.088736735,-0.0063404455,0.0075053773,-0.036761243,0.054308686,-0.010561112,-0.08450448,0.04159321,0.07939306,-0.027319822,-0.038671523,0.015192751,0.047626883,-0.07325708,0.03332415,0.08155462,0.04009452,0.075843446,-0.088442735,-0.013888698,-0.004719533,-0.07125919,-0.09676101,-0.06175482,-0.0037734536,0.08651535,0.08082811,0.012918238,-0.00232833,-0.08564127,0.04590703,0.037750565,0.0003011597,-0.023929164,0.0344986,0.02176528,-0.06262055,-0.02313017,0.043095373,-0.0054562716,0.030234631,-0.08088211,-0.0024541705,-0.005707871,-0.10918693,0.015562119,-0.022345103,-0.10142669,-0.06673912,0.001516538,-0.030862678,-0.02348718,-0.013718994,0.053914577,0.024494506,0.021783954,-0.093296394,0.08322183,0.038376004,0.03987127,0.0796196,0.029561881,0.01991686,0.04582577,-0.023698939,0.094738446,0.0061477893,0.011691812,0.05901268,0.0011678222,-0.040484294,-0.07526077,-0.014003948,0.06726514,-0.016307661,-0.0051440657,0.040222634,0.067750365,-0.015325603,-0.06569403,-0.07490066,-0.06599289,-0.011295836,-0.05020554,-0.00033067353,-0.08100317,-0.03499195,-0.005353993,-0.016162846,-0.007124802,0.03512258,-0.04281731,0.107570425,-0.040532954,-0.05261362,-0.034091715,-0.11279263,-0.03685478,-0.032658555,-0.0059318757,-0.0075598466,-0.03233822,-0.017128922,0.019156618,-2.8920463e-34,0.0097332075,0.0069458033,0.0397049,0.034739908,-0.019142406,-0.029841196,-0.009656187,-0.016398218,-0.09123793,-0.07873853,-0.07073032,-0.05529244,-0.043305907,0.0438122,-0.008169501,-0.0840093,-0.0044583315,0.061615504,0.04860682,-0.0056629684,-0.018644622,0.09657212,-0.055955056,-0.04093886,-0.039266597,0.07746578,-0.055193685,-0.044968173,0.041764848,0.008863202,-0.09861597,-0.040299848,0.01376458,-0.005329736,0.017109495,0.044064693,-0.023710718,-0.016673101,-0.006989038,0.057610184,-5.965907e-05,0.00073574955,-0.000530282,-0.045614865,0.023282614,0.058244593,-0.017525032,0.040065046,0.009777562,0.04547928,0.015460648,0.031451453,0.057568654,0.008286765,-0.11718194,0.03758887,-0.019160407,-0.01606237,-0.0469242,0.034449365,0.012035771,0.025328454,-0.057280876,0.029635612,-0.02392155,0.043250952,-0.048155397,-0.041850235,0.040935017,0.10464674,-0.07357552,0.00160813,0.091851816,0.07706986,0.10053538,0.07883902,-0.003358246,0.011004896,0.0053238287,0.04338428,-0.08814806,0.013948265,-0.04372681,-0.0018292024,-0.052306395,-0.039073437,0.012034984,0.0042941296,-0.048909288,0.04211011,0.048218228,-0.10315175,0.0006799719,0.039247382,0.012749808,-2.3170244e-33,0.014696673,-0.06944889,0.096632615,-0.03714371,-0.024571193,0.11656817,-0.0027918315,-0.050477657,0.014630663,0.055667702,0.035591736,0.05499233,-0.012985308,-0.03467521,-0.040559217,-0.0691448,0.06931231,0.06729011,-0.09189089,0.033626523,0.02333202,0.062787324,0.0050255028,0.081332445,-0.023081424,0.0015752116,0.06488859,0.040803414,0.037297048,0.0623294,-0.007460052,0.018312465,-0.042052943,0.030961696,-0.006049427,0.06582001,-0.089454345,-0.009515753,-0.038157146,0.022713786,-0.116913535,-0.057441417,0.0025670389,0.021412188,0.07763065,0.014376261,-0.078028746,0.05582318,0.03910223,0.005372827,0.07560076,0.08112731,-0.009435587,0.02795978,0.015229377,0.063759394,0.0043235454,0.007963913,0.07986997,-0.003415128,-0.0650297,0.006597109,0.00040407048,-0.04581021,0.008767355,-0.003152018,0.005532069,-0.05474289,0.049825374,-0.017676448,0.12750751,0.07661437,0.008935096,0.047824968,0.024785908,-0.011602086,0.0197353,-0.1651331,-0.029354831,0.018062836,-0.041696705,-0.03928616,0.036811803,-0.02304907,-0.10451756,-0.054086104,0.02566885,0.009036411,-0.0012104131,0.004523978,0.035748247,-0.0021605922,-0.07487583,0.07995415,-0.0024562688,-2.9525305e-08,0.0057367976,-0.012165003,-0.014688736,0.036345545,-0.04346491,0.03289569,-0.03061446,-0.03530247,0.056505788,-0.070999786,0.035497837,0.07265668,0.031953435,0.029099127,-0.021390717,0.051152464,-0.012685159,-0.0077101802,-0.023534456,-0.053996142,-0.114389345,-0.06245076,-0.06367135,-0.019811552,0.0036785838,-0.1277917,0.026139123,0.053161617,-0.004508579,-0.006624627,0.054102868,-0.00054663414,-0.0797595,0.014131861,-0.015293417,0.06410957,-0.021302674,-0.009177956,0.09658277,0.067520425,0.022647722,-0.08219189,-0.044921856,0.016689781,-0.05294777,0.024557954,-0.050001424,-0.05537359,-0.02882022,-0.038289916,0.024839472,0.012635824,-0.0085275965,-0.09310703,-0.05134205,-0.004423571,-0.033024706,-0.019251538,-0.017644305,-0.09199858,-0.042653095,0.013161122,0.19581544,0.040375147 +4.2.3.18,"Part of a bifunctional enzyme involved in the biosynthesis of abietadiene. See also EC 5.5.1.12, copalyl diphosphate synthase. Requires Mg2+.",384,0.99999994,-0.09836679,0.033254072,-0.01239305,-0.0030300005,0.012563432,-0.029145502,-0.019844603,0.066467926,0.004602381,0.0043368833,0.005922115,-0.06682627,0.037238296,-0.100205414,-0.022788178,0.027045699,-0.057017107,-0.0050463537,-0.049001116,-0.04587206,0.14609797,0.054216318,-0.0056391726,-0.004294633,0.006596294,-0.0028318665,0.076173946,-0.064998396,0.057670753,-0.060239006,-0.023187105,0.026501203,0.009528783,-0.05854566,0.0064828163,0.101612486,-0.03326076,-0.04099357,0.011473633,0.038478654,0.07715747,-0.0062115598,-0.037221853,-0.08441127,-0.0038311244,-0.085663706,0.026926117,-0.021058286,0.026505556,0.021245612,-0.043054134,-0.030139383,-0.07521894,0.009736118,0.07426728,-0.0065594953,-0.054548692,-0.034133226,0.012654413,0.014696278,0.0399417,0.029642383,-0.04832404,-0.03440733,0.030261412,-0.05625901,0.029952584,-0.07553949,0.028875364,-0.059419155,-0.027818589,-0.0904873,-0.0067322277,-0.017115751,-0.04106136,0.032388896,-0.013111778,-0.043857705,0.052687515,-0.034549017,0.032638345,-0.044417024,0.045004904,0.011874316,0.03870849,0.04768853,0.115377195,-0.026692364,0.010385518,-0.032092977,0.045940768,-0.057813045,-0.016617874,-0.013688962,-0.020083893,0.06348961,0.034113582,2.97347e-05,-0.012309549,0.018139612,-0.0012588594,0.072883874,0.011387889,-0.005794359,-0.113647066,-0.034053747,0.025213521,0.03848983,0.055521592,0.01624901,-0.01387803,-0.06993229,0.01919965,-0.0145599255,-0.018358786,0.093032606,-0.042773448,-0.081810325,0.037319373,-0.047299147,0.041860178,0.06333009,-0.024478935,0.11161847,-0.013162279,0.03623511,-0.0640709,2.4555871e-33,0.050167125,0.0026692667,0.03860561,0.021286635,-0.07388195,0.044318825,-0.097384706,0.023466228,-0.021598617,-0.10764757,-0.046174075,-0.11195923,0.019876882,0.04668193,0.012654191,-0.06686555,-0.005573189,-0.024826137,0.09617378,-0.039647542,-0.029502317,0.040962733,-0.054320343,0.051909987,0.00065651693,0.035540715,-0.0022386564,-0.024783673,0.029171497,-0.009116602,0.026092004,-0.066942304,-0.10479843,0.035588592,0.009438369,-0.045961138,-0.0008872129,-0.08938108,-0.099168055,0.05062033,-0.037833877,-0.016339049,-0.006790889,-0.031055095,0.042348456,-0.07182979,-0.041307736,0.042553615,0.08174425,0.071287386,0.023228386,0.081121065,0.13159473,-0.01040601,-0.09417614,0.08001363,-0.013499631,-0.012091044,0.06489897,0.04666919,0.053543113,0.045625106,0.04274992,-0.01677275,0.0060858065,0.09614174,-0.08328128,-0.0316961,0.067345284,0.040036667,-0.029174043,-0.03204008,0.07031723,0.058045674,0.023971483,-0.004258311,-0.014434153,0.0092256535,-0.058377974,0.049765103,-0.046546027,-0.03015551,0.029167354,0.02175057,-0.03257148,-0.023946488,0.029197587,-0.054727715,-0.010370905,0.045548163,0.029724881,0.008397484,-0.052892923,0.07709744,-0.032252368,-3.393958e-33,0.080929704,-0.06495443,0.06802897,-0.113111496,-0.06893678,0.01718261,0.036034945,-0.06214673,-0.014159271,0.016749,0.047242556,0.010238877,0.08394056,-0.10719201,0.001193465,0.078129746,-0.026438976,0.09847059,0.03631829,0.04261709,0.038650252,0.07511923,0.09044261,0.014502014,0.030532926,-0.0058478992,0.065466106,-0.025686422,-0.011551765,0.018773943,-0.026641192,0.035915904,-0.08105097,-0.035428796,-0.12188054,0.074029796,0.006572354,0.0077795414,-0.017593823,0.008836486,-0.032945853,0.0682404,0.03424692,0.07352799,0.09681046,-0.0046182214,0.032710705,0.029105121,-0.04052397,-0.100538604,0.039743174,0.027921014,0.0062064654,-0.041320857,0.02643592,-0.019967737,-0.02905997,0.047519606,0.06992539,-0.056208123,0.028820807,-0.023301553,0.04735119,-0.042550422,0.06867835,0.075373515,-0.042541813,0.039973464,0.045228034,0.020821651,0.10623586,-0.0025930246,0.042798553,0.041890275,0.021141587,0.04781204,-0.03808992,-0.058020417,-0.035178,-0.07086976,-0.009861687,0.010631192,-0.013379051,-0.01587154,-0.11258676,-0.07959668,0.015713004,0.04249372,0.023327596,-0.0190084,-0.08355359,0.014619466,-0.0570709,0.0853234,0.062453557,-3.0367534e-08,0.04414502,-0.06701859,-0.009875335,-0.025466315,0.064797595,0.01000419,-0.036258027,-0.05755848,0.06589506,0.026907407,-0.09363064,-0.008062024,-0.0313371,0.005576277,0.018024666,0.021386215,0.0053628343,0.10786884,-0.019867694,-0.036880232,-0.042628296,-0.020451363,-0.057964098,0.06695174,0.025042223,-0.08920911,0.04310936,0.030878257,0.008773427,-0.0307165,0.013853983,0.020778637,-0.008477472,-0.060715243,0.0028586918,0.05437398,-0.00786156,0.031562816,-0.06784626,-0.017643025,-0.03670854,-0.086895496,0.087092504,-0.009840396,0.013878275,0.0070877867,0.015487585,0.0398859,0.03321251,-0.02776522,0.050260726,-0.070847124,0.030384501,-0.059443343,-0.09399053,-0.06081571,-0.037264686,-0.07573367,0.029352525,-0.0659239,-0.007445562,0.09351541,0.12781008,-0.034055356 +4.2.3.19,Part of a bifunctional enzyme involved in the biosynthesis of ent-kaurene. See also EC 5.5.1.13 (ent-copalyl diphosphate synthase),384,1.0,-0.118391916,0.028135387,0.007716648,-0.002605728,0.051921304,0.034708366,-0.034120277,0.04722266,0.06108785,-0.0099656535,0.01730831,-0.08216603,-0.028151866,-0.06699301,-0.06169051,0.00034082474,-0.11211393,-0.01771128,-0.009371862,-0.062020153,0.08425288,0.05170818,-0.017429944,-0.011609547,0.0577445,0.0002554753,0.018698636,-0.07053652,-0.0050882366,-0.07577959,-0.06526346,0.016277492,-0.028474405,-0.0399891,0.015515654,0.08479068,-0.06493702,-0.0052705146,0.063153826,0.004855207,0.07666657,-0.029403768,-0.13154891,-0.03467854,0.008902369,0.009957272,-0.027086416,0.011298841,-0.049024753,0.05220659,-0.01969828,-0.055883545,-0.028024502,-0.0026085223,0.08712586,-0.03262011,-0.054929797,0.028969621,-0.0035892548,0.05139069,0.12260742,0.0075798635,-0.04919452,-0.023601752,0.036457106,-0.1315295,0.034538824,0.015051986,0.00825096,-0.068364896,-0.026305716,-0.07498249,-0.028102046,0.04510582,0.019429062,0.0595179,-0.0117572015,-0.031298634,-0.0022674454,-0.012408913,0.10267656,-0.004899863,-0.021073647,-0.0340898,0.043111093,-0.018188184,0.047140628,0.026313854,0.017229658,0.0007933498,-0.011558912,-0.06604975,-0.032665912,-0.029970478,0.03971912,0.018030627,-0.03788549,0.06038697,-0.0133637,-0.057005838,0.030635126,0.10192802,0.02403939,-0.062359355,-0.052523553,-0.07710319,0.024390532,0.048187397,0.010048527,-0.036355563,-0.05867381,-0.083628766,0.08989076,-0.030148713,-0.009661471,0.08628339,-0.02917272,-0.06479406,0.019155862,0.002770848,0.057976212,0.046846595,-0.022876477,0.12941127,-0.02952419,0.027300209,-0.048795544,7.927586e-34,0.09795537,0.03623089,0.0358914,0.027774839,-0.043714717,-0.0019728232,-0.05434865,-0.0025001278,-0.10447007,-0.057335004,-0.033398397,-0.1244536,0.06333306,0.021523263,-0.0468703,-0.006383486,-0.029168433,-0.023281373,0.07258823,-0.024110993,-0.01479656,0.064984374,-0.10578528,0.05112147,-0.028263224,-0.033739418,-0.029911831,-0.01881211,0.028634934,-0.03651461,0.046040878,-0.035388883,-0.06964749,0.024213137,0.030176787,-0.06321572,0.03806982,-0.03842555,-0.04850787,0.05691003,0.040471613,-0.004017452,0.040930275,0.0030589974,-0.018198818,-0.024053892,-0.077238515,0.047621015,0.06701361,0.050851073,0.056561437,0.032473885,0.11645963,-0.04224829,-0.056045633,0.105395615,0.018599015,-0.056932338,-0.01046,0.033941872,0.0021550255,0.012813299,-0.015515321,0.0056306524,0.0004672999,0.022788573,-0.07429171,-0.027655989,-0.010516842,0.07902038,-0.09955647,-0.034001924,0.054717615,-0.026040649,0.028209934,0.004518964,-0.10490023,0.025910402,-0.12319325,0.05358024,-0.025838628,0.0017091634,-0.013048209,0.014287276,-0.026460186,-0.067544,0.0010693218,-0.045187216,0.059314348,0.068936974,-0.0029003574,-0.032739762,-0.08819868,0.038806908,-0.01627905,-2.9428543e-33,0.12468239,-0.05631708,0.056044552,-0.047145132,-0.06628347,0.082409665,0.032441866,-0.027067028,0.034680452,0.06981896,0.082388856,-0.03242248,0.082233176,-0.04764654,0.0019691335,0.05539867,-0.013592271,0.055441555,0.058422875,0.030341543,-0.0032309452,0.04708807,0.044555105,0.041250456,0.0111844335,0.062033672,0.018955724,-0.015157809,-0.023825858,0.032903202,-0.020223636,-0.10081415,-0.048547465,-0.0029269408,-0.10773298,0.06002352,0.037266914,-0.0017704484,-0.016676424,0.003822252,-0.012351653,0.05808764,0.04810486,0.055221226,0.07544714,-0.032857545,0.053138934,-0.009289226,-0.061997976,-0.094201244,0.06604054,0.060050175,0.0071311565,-0.0070281513,0.014830293,0.021458957,-0.03913607,0.066434436,0.0286611,-0.0149790235,0.043671127,-0.06317619,0.047340598,-0.08879261,0.01596159,0.0090872105,-0.05220633,0.07570086,0.060415633,-0.05695978,0.033478133,0.006105427,0.038353935,0.05622286,0.016440392,-0.024727447,-0.031138165,-0.0136303175,0.026884602,-0.04002035,-0.033066258,-0.023576029,-0.030909542,-0.044402957,-0.06625659,-0.046254672,0.017410593,0.0776334,0.051857345,-0.035719227,-0.09189617,0.010580524,-0.052826438,0.13053146,0.049496457,-3.0631224e-08,0.12820183,-0.10811164,-0.022230322,-0.017918233,-0.038798284,-0.040231775,0.034194373,0.020767562,0.044525776,0.016817203,-0.047982715,0.019999709,0.033258695,-0.026059268,0.08192732,-0.0028806238,-0.056846946,0.10337354,-0.003999081,-0.030442543,-0.019501558,0.0055052363,-0.08552632,0.033495642,0.03942237,-0.030990798,0.010449151,0.012995871,0.012195881,-0.012516047,0.011701103,-0.008037782,-0.01065745,-0.060875315,0.007246132,0.050921727,-0.04944215,-0.014268487,-0.020933118,0.05751918,-0.04556406,-0.05323932,-0.031103337,0.020762458,-0.030431358,0.023319488,0.04462518,0.031191872,0.030379824,-0.037569754,-0.025115928,0.021064412,0.028358575,-0.038722865,-0.08146647,0.020159902,-0.006642358,-0.086328216,0.034714814,-0.06257888,-0.029252738,0.085525855,0.15922382,-0.0008503376 +4.2.3.20,"Forms the first step of carvone biosynthesis in caraway. The enzyme from Carum carvi (caraway) seeds requires a divalent metal ion (preferably Mn2+) for catalysis. This enzyme occurs in Citrus, Carum (caraway) and Anethum (dill); (-)-limonene, however, is made in the fir, Abies, and mint, Mentha, by EC 4.2.3.16, (4S)-limonene synthase.",384,0.99999994,-0.046448242,-0.065276094,-0.09519572,0.023124812,-0.0075625316,0.046549115,-0.06478806,-0.019301359,0.018885786,-0.013241935,0.010860302,-0.08769882,-0.089199886,-0.0377601,-0.057963893,-0.004637756,-0.06839097,0.042345647,-0.057548344,-0.018682655,0.07682556,-0.019286409,-0.014509335,0.009693422,-0.03978525,-0.006770997,0.04460464,0.0056524565,0.060463358,-0.034570783,-0.01275641,0.0038870734,0.08218288,-0.030492626,-0.027088564,0.0029282437,0.054815333,-0.019858068,0.0896965,-0.012471577,0.053708993,-0.0129160145,-0.04794779,-0.054961186,0.04522588,-0.0999999,0.07267656,-0.033370726,0.004382145,-0.08285481,-0.022929449,-0.02693522,-0.022402577,-0.08817284,-0.031034134,0.028318819,-0.021065194,0.05649538,0.020049917,0.027248925,0.10698057,0.0050844564,-0.055384003,0.02190718,-0.087931156,-0.036178574,0.044470664,0.022095537,0.06444721,-0.034528207,0.0243706,-0.11447561,-0.050197486,0.0017407,0.007384435,0.1645967,0.10303259,-0.054453082,0.03259682,-0.057935763,-0.004068628,0.0135211395,0.048129227,0.048512645,0.0054611717,0.040073916,0.02686065,0.028301332,0.06768111,0.052526142,0.0443467,-0.009201656,-0.017137418,-0.04176351,-0.027733048,0.058694385,0.09729003,-0.076496765,0.037817877,-0.01839839,-0.03702319,0.059421606,-0.013724032,-0.035994563,-0.023183728,0.08408553,-0.028476838,0.07591939,0.036901757,0.025580091,0.038989518,0.020769075,0.03197216,-0.007928792,-0.06649153,0.057920635,-0.027936706,-0.02386199,-0.027007453,0.01482969,-0.035966452,-0.023831228,-0.047634736,-0.017832587,-0.020277184,0.0032169723,-0.0713777,-2.5054842e-34,-0.016215283,0.06036756,0.023570238,-0.011111625,0.08227199,-0.047948744,-0.07345894,-0.015929403,-0.017308213,-0.0656533,-0.082433574,-0.07509683,-0.033428706,-0.05706199,-0.011908191,0.016192904,-0.0705464,-0.06963057,-0.013523672,-0.027230376,-0.075157344,0.01496834,-0.045879252,-0.005574309,0.01937216,0.022860896,0.073279,-0.06846881,0.036935955,-0.010749601,-0.030036438,-0.03605888,-0.01376987,0.033356342,0.032555904,0.025847599,0.013604529,-0.018108193,-0.0073671066,0.023048809,0.03729714,0.056646034,-0.010936959,0.015742367,-0.04560692,-0.08057391,-0.049264245,0.11434152,0.093733035,0.082516305,0.033484984,0.012283469,0.0787842,0.034989826,-0.07776778,0.11722065,-0.063350156,-0.0046886127,0.07791389,0.03788004,0.01750683,0.00444184,0.04594981,0.06490334,0.03146946,0.039521743,-0.1261177,-0.015542633,-0.00732447,0.04774219,-0.038088955,-0.032982998,0.005910475,-0.0056090476,0.0657835,0.037041232,0.012810783,-0.020164248,0.040398482,-0.048282433,-0.06715869,0.047544956,0.009633094,0.011579016,-0.024118872,0.022552041,-0.062433854,-0.002043385,0.013976001,0.06997488,0.01070742,-0.02076626,-0.016011098,0.019049997,-0.061749108,-1.3073331e-33,0.037324168,-0.055346683,0.087021515,-0.041677214,-0.003296343,0.060014002,-0.014823712,-0.10531281,0.022658274,-0.005781519,0.016358027,0.03853019,0.08910238,0.0028042784,-0.03397377,0.022709984,0.07383005,0.06822951,-0.052691642,-0.030666104,-0.011399837,0.031830017,-0.06748602,0.05056237,0.023204738,-0.019429673,-0.043812755,0.054902002,0.026873026,0.028891968,0.1357236,-0.0049422984,-0.03269332,-0.026279625,-0.025618743,0.08795021,0.032151684,0.011112126,0.02739952,0.12176181,-0.07018569,-0.048872806,-0.028439565,0.06976943,0.05568684,0.044377632,0.002887814,0.018489579,-0.04376733,-0.022684632,0.072189726,0.04239333,-0.054854568,0.050382327,0.0077576493,0.039852884,0.110737786,0.010986188,-0.019728286,-0.0241626,-0.03152822,-0.022950398,0.020369368,-0.04547386,0.032181308,-0.016385099,-0.010270259,0.044938006,0.00497776,-0.09348232,0.13052368,0.04467465,-0.00096304435,0.08240251,-0.04354061,-0.043644298,0.008695868,-0.12174204,-0.0013857029,-0.08218628,0.06330067,0.010706482,0.06613082,-0.019486738,-0.071526036,-0.020116102,0.06612316,0.05881558,0.030740323,0.03828965,-0.029251928,-0.0044368776,-0.0691277,0.07030908,0.08498961,-4.0747576e-08,0.02737346,-0.056581274,0.0034462018,-0.02980781,-0.08005377,0.02405123,-0.00049752457,0.031381648,0.032684527,-0.08275521,-0.03300921,-0.031390928,-0.027248539,0.01806354,-0.023258371,0.02660546,-0.022965511,0.05414574,-0.0659101,-0.020445839,-0.09932329,0.024360046,-0.11335163,-0.0484008,0.00769796,-0.1545124,-0.025456559,0.01756888,-0.011689327,-0.027198896,0.0320828,0.07279266,0.008592736,-0.0077047464,-0.076426126,0.00887763,0.021683117,-0.0032032537,-0.0009334013,-0.037254736,-0.012673999,-0.077144235,-0.059439905,-0.011254146,-0.04417792,0.027878499,-0.02808175,0.09307134,0.038965166,0.019566413,0.07021485,0.0061427853,0.03352068,-0.07152502,-0.08686894,-0.011563047,-0.06796631,0.018944949,0.04131405,-0.047361158,-0.038613074,0.04732515,0.15262137,-0.06228928 +4.2.3.21,The initial internal cyclization produces the monocyclic intermediate germacrene A.,384,1.0,-0.031076116,0.035276327,-0.044198424,0.02458286,-0.0046015806,-0.073978856,0.018975515,0.057647564,0.049774274,-0.025614584,0.058718998,0.009337876,0.05335625,0.07307454,-0.030778252,-0.040289525,-0.0831736,0.0064845225,0.019043602,0.043111246,0.029369362,-0.009804925,-0.027763197,0.06811936,0.108730435,-0.025107719,0.017461183,0.0069493405,0.019149944,0.012746291,0.0043501835,0.03599342,0.038899682,0.013751983,-0.007512489,0.03276379,-0.05441595,0.038917147,0.052320477,0.005592656,0.018822365,-0.012377903,0.035290632,0.024096,0.002945017,0.011014471,0.011385215,-0.020127987,-0.027467392,0.002187061,0.018215451,-0.038001128,-0.03864861,0.0070604216,0.015182267,0.026662614,-0.09178044,-0.0032851903,0.036909375,-0.006969568,0.026671082,0.033431936,-0.027064025,-0.027657324,-0.004887176,-0.024542755,0.068669215,-0.0783596,-0.003098916,0.01285893,-0.02709548,-0.051520642,-0.038848702,-0.06903433,-0.018401796,0.028540595,-0.037796788,0.030886259,-0.03462041,0.028721556,0.057484534,0.069522634,0.04981939,0.08452462,0.060016327,0.04791446,0.046641637,0.04715085,-0.0277878,-0.009774725,0.013954012,-0.01321042,0.029393291,-0.06044967,0.010533059,0.02039009,0.047224004,-0.07735103,0.062607884,0.020510083,0.07052914,0.029218052,-0.015941625,0.00025916606,-0.018896244,0.04358226,0.005865291,0.06549208,-0.033701453,0.012389421,-0.02466004,-0.02659157,0.029338058,-0.074147746,-0.025388505,0.14943545,0.03262511,0.019927358,0.05023921,0.044478364,-0.0121753,0.033333603,-0.02389715,0.06760779,-0.021309864,0.06750598,-0.008189925,1.8065172e-33,0.006862132,0.0018449073,0.084195554,0.059969228,-0.09067807,0.051207405,-0.020535577,-0.015920434,-0.043021332,-0.057174716,-0.051418282,-0.021784842,0.05042506,0.046977945,-0.06923774,0.007934254,-0.011047454,-0.014306471,0.008362482,-0.04798333,-0.062149826,0.035488553,-0.024422966,-0.023619354,0.0091229575,0.023514103,0.005140278,-0.0074524144,0.053503934,-0.019128688,-0.057341415,-0.00069001835,-0.1008999,0.072269134,-0.0003949545,0.06470641,-0.043991387,0.017476678,0.076159485,0.030625544,-0.018330717,-0.001955587,-0.028367043,-0.063194185,0.074655235,-0.012076143,-0.09463506,0.151321,0.008660929,0.022448517,0.04322342,0.0038411708,-0.08166439,0.032357976,-0.07940385,0.041595425,-0.008759115,0.008402992,-0.026743963,-0.006655124,-0.007413896,-0.005972345,-0.095989205,0.0155978445,-0.031327017,0.11300246,-0.14000334,-0.052064665,-0.02874532,0.050960507,-0.039402716,-0.042150814,0.07810702,0.10375453,0.02218598,0.09101536,-0.08609532,-0.052219916,0.06287084,0.060999732,-0.024648651,0.022309689,-0.055448793,-0.023456348,-0.026940508,-0.010054863,-0.02360791,-0.11215498,0.0076189153,0.08479608,-0.02532725,-0.0392062,-0.026486548,0.0112215625,-0.011780101,-2.2741948e-33,0.075042345,-0.05040573,-0.028648257,-0.052394893,-0.036626786,0.0013359875,-0.042795405,-0.21901476,-0.065859675,0.033040926,0.05598274,-0.0119445175,-0.002318112,0.025646823,-0.048598047,-0.09365532,0.026436651,0.114541665,0.09575241,0.054199636,-0.0031572173,-0.008567735,-0.028279424,-0.03991412,0.04700021,0.026748959,-0.081144266,0.07485042,0.0815558,0.061761614,-0.06326644,-0.0019153265,-0.0057037803,0.0028652921,0.012167272,0.050916124,-0.06341738,-0.07168071,0.024427539,0.021874044,-0.11979698,-0.08315454,0.08116576,0.079863265,0.1571363,0.033195723,0.016369414,0.009782396,0.009174514,-0.05029198,-0.05949215,-0.0018913858,-0.014526992,0.011915979,-0.061878636,0.074294776,0.07406169,0.036168475,0.073943816,-0.11026483,0.03730269,0.048974212,-0.008548659,-0.096722126,-0.034030084,-0.03270702,0.02540484,0.10228569,0.012379456,-0.087083705,0.035575293,0.028718822,0.07781014,-0.076244116,-0.016176544,0.01007192,0.027592506,-0.0840354,0.005031679,-0.10465626,-0.03788493,0.0470612,-0.017947625,-0.031086467,-0.052291438,-0.05823906,0.046527132,-0.044025693,-0.0032232285,-0.020955572,-0.018680448,0.040966574,-0.036548804,0.1002974,0.09572228,-2.2482837e-08,0.04098071,0.03973738,-0.070986174,-0.024793655,0.033433225,0.022509752,0.0015622627,-0.024392225,-0.038016032,-0.063790604,-0.01998764,0.031434644,0.055594485,-0.02353448,0.025432255,0.016117388,-0.018886188,-0.08349686,-0.039848566,-0.035833392,-0.03943778,-0.00412052,-0.06868939,-0.07170723,-0.11530385,-0.10489683,0.027994024,0.032179408,-0.01028103,-0.012922362,0.04899048,0.024486698,0.039385296,0.00783325,0.0058353725,0.030481026,-0.012328446,0.042611834,0.036501817,-0.10299403,-0.003525887,-0.020019867,-0.10495785,0.0013637798,0.01305951,-0.038305428,0.0014133761,0.012743008,-0.043510504,0.04583645,0.020009078,-0.0060736043,0.0058021657,0.014546553,0.0060053733,0.0039045725,-0.008301491,-0.0109484745,-0.020883337,-0.066269785,-0.10333361,0.03155261,0.11555805,0.030999774 +4.2.99.18,"'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under EC 3.1.25.2.",384,1.0,-0.056356415,-0.07206851,-0.035179764,-0.04218689,0.10548643,-0.015303882,-0.013376876,0.045907285,0.018030459,0.027296184,0.030223176,-0.024736494,-0.09408285,0.1215837,-0.02161035,0.07668465,-0.14280266,-0.036098737,0.005353375,-0.01891354,0.044085767,0.040360205,-0.030349476,-0.011481308,0.059827283,0.026737634,0.065261796,-0.08327418,-0.03681685,-0.086333014,-0.0029455253,-0.040556915,0.036578335,-0.07586589,0.055777244,0.096218124,-0.050721824,-0.046803966,-0.032468338,0.01467309,0.059379555,-0.04080298,0.042256944,-0.10228076,-0.039733704,0.020636393,-0.021134635,0.0135067655,0.0526876,0.025853978,0.06938888,-0.0924169,-0.018318027,-0.0064479224,-0.057108916,0.05448731,-0.062313117,0.007418686,-0.03957892,0.07816544,0.01596389,0.04649245,-0.0073704235,0.025693383,0.023036737,-0.033737637,0.090162516,-0.06311081,0.014174831,-0.007728584,0.019389397,-0.08685985,0.014907671,0.010263745,0.043570574,0.07154303,0.014863436,-0.009689207,0.009502471,-0.043027543,-0.0273637,-0.0812978,0.05414058,0.019125547,-0.028550863,-0.038250554,-0.018639486,-0.048946396,0.034242854,0.04585834,0.012566067,-0.023896592,-0.058554217,0.008499595,0.026118407,0.03624498,0.021841927,0.013790042,-0.04060239,-0.01973397,-0.021767912,0.023786716,-0.034271985,-0.06811662,0.05103326,0.059730455,-0.024584716,0.041149784,0.011335149,-0.0016052328,0.052239716,-0.005051988,0.10287539,-0.08422199,-0.0057012793,0.039617836,0.0007009696,-0.035333693,-0.001389297,0.059043303,0.056917753,-0.024231914,-0.015777066,0.05289849,-0.04674308,0.055965606,-0.0706424,-7.577435e-34,0.069811806,0.02088965,0.0013825,-0.07633798,-0.061745826,0.010674401,-0.0591346,0.009243585,-0.015811516,-0.09389949,-0.023645945,-0.02642946,0.03130492,0.02724378,-0.047081467,0.036898673,0.054766115,-0.0100966105,-0.0014725747,-0.019910194,0.032971904,0.047227204,-0.064726144,-0.005119562,0.0042679072,0.055542212,-0.05512083,-0.027733237,0.030504312,-0.014716303,0.039749622,-0.009274315,-0.014296242,0.109023534,-0.0043415953,0.06554289,0.037768416,-0.045166366,-0.014147554,-0.06253879,0.04958392,-0.004445022,-0.05730559,-0.034308046,0.049719807,-0.04620043,-0.04685492,0.04614443,-0.0034991396,0.022844084,0.032671493,-0.020948036,0.0030298945,0.07604783,-0.027236886,-0.0023437655,0.009093666,-0.03163361,-0.0006432623,0.037858825,-0.03399974,0.13475457,0.012344091,-0.02996442,-0.05786739,-0.04370914,-0.011963058,-0.030370733,-0.064369075,0.015065048,-0.098902784,0.021734383,0.07573988,0.009021365,0.0013677609,-0.060974184,0.0099773435,-0.0006400632,0.030119123,0.061132733,0.089238696,0.02384217,0.07192935,0.03412267,-0.06791671,-0.034581106,0.033375107,-0.08895964,-0.029465364,0.08759198,0.062142517,-0.021894284,-0.051632665,0.08472695,-0.025284505,-1.61975e-33,0.075328894,-0.06648045,0.028168118,-0.038663376,-0.038789015,0.029309677,0.056053285,0.04448505,0.036624514,-0.042658,0.06877604,-0.043509107,-0.08291396,-0.07310521,0.013503049,-0.032225147,0.05674222,0.065288454,0.029223654,0.01860391,-0.037111547,0.11292329,0.014700937,-0.0008598044,0.1545477,-0.048514776,0.00047210528,0.012360138,0.0068006692,0.0507105,0.022703502,0.036610663,-0.022369783,-0.06390616,0.008014934,0.04966607,-0.097081155,-0.023729784,0.07431084,-0.04799291,-0.0046920646,-0.03193443,0.027375592,0.05647615,0.058950607,0.035702027,-0.0711449,0.06552669,-0.043946404,-0.049418565,0.0035216995,-0.009731794,0.008616875,0.057141844,-0.041132815,0.011929126,-0.0072289617,0.05019498,-0.037916433,-0.041243147,-0.02676815,-0.029401714,-0.027666386,-0.0730613,0.013247867,-0.001281564,-0.028925108,0.09975398,0.066976175,-0.03128841,0.030698156,0.008975395,0.04328311,0.029417895,-0.00021090002,-0.02221219,-0.12352994,-0.110710226,0.025588805,-0.08536033,-0.071033746,0.060372896,0.031597998,-0.023270486,0.08607056,-0.09144117,0.016466502,0.109101675,-0.025745459,-0.0040144557,0.025242785,-0.023174366,-0.023697875,0.061973974,0.04151757,-3.6427117e-08,0.06232351,-0.053964384,-0.0051827426,-0.07139749,0.051295646,0.011573373,0.115271494,0.04069888,-0.0027452477,0.020172136,-0.021813186,0.07021317,-0.05279341,-0.034387756,0.061333627,-0.012605449,-0.033443175,0.025305515,-0.03540722,-0.0077646356,-0.12506455,0.0061954786,-0.16349386,-0.018809471,-0.05923768,0.029571688,0.12026259,0.03144931,-0.06174998,0.00019769848,0.06324736,-0.0042191516,-0.025138436,-0.0025114617,0.002679468,0.08079559,0.019345358,0.00018079077,-0.015125789,0.0009780766,-0.046359323,-0.0101851495,-0.01570711,0.016080797,-0.065187186,-0.047581587,-0.021795554,0.030650347,0.020885719,-0.041782364,0.06263235,-0.042075988,-0.08678735,-0.10313184,-0.06406171,-0.043759048,0.03828198,-0.0463619,0.008183817,-0.023833318,0.02452016,-0.052457098,0.17022362,0.047070965 +4.3.1.2,A cobalamin protein.,384,0.99999994,-0.06870766,0.011437994,-0.11470438,-0.015760722,-0.047259904,0.049371425,0.059385505,0.038116183,0.058374066,-0.04834327,0.023236334,-0.09614474,0.011807483,0.014048942,-0.015276668,-0.0347884,0.0831031,-0.016098255,-0.06860744,-0.1136095,-0.06596166,0.08337052,-0.025793606,0.017544555,-0.018330263,0.01728738,0.020980109,-0.022479344,0.020105243,-0.02608002,-0.025836656,-0.0019247843,0.039165497,0.029491229,-0.0689073,0.06621256,0.025095975,-0.04355875,0.06407768,0.0007071942,0.053661507,0.07740956,0.031768646,-0.015974537,0.037579883,0.025917744,0.016453775,0.09465446,0.07160023,0.054680023,-0.07774146,-0.09470757,-0.037391625,0.045029566,-0.018389523,0.013400241,-0.08666109,-0.0112543255,0.013343187,0.026724502,-0.02423042,-0.04876207,0.06788585,0.03500842,0.08970227,-0.055710386,0.0073686447,-0.0012968555,0.055426672,-0.018645257,0.07581937,-0.018050747,-0.012890211,0.016244598,-0.03697361,0.045356844,-0.0582229,-0.05937572,0.01966747,0.01217623,-0.0071156523,0.03684094,-0.0028222976,0.13026229,0.051442463,-0.06395132,-0.019168127,0.069859155,-0.03920627,0.022880925,-0.014237379,-0.0009507272,0.053000543,0.018072948,-0.0883744,0.022236127,-0.006388339,-0.01703426,-0.052769244,0.011750771,-0.031539068,0.047656458,0.07396142,-0.0050795665,-0.010104141,-0.0525953,0.03578527,0.12107159,0.010763601,0.000810065,0.0077444045,-9.5077405e-05,-0.01203443,-0.039566293,0.004901102,0.054528233,0.08294189,-0.0108835,-0.11312781,0.033119727,0.026859382,-0.008749201,0.007591337,-0.027437253,-0.043196082,-0.028235545,-0.03901976,-3.8345614e-33,0.061286546,-0.035993066,0.0558929,0.059935816,0.016886229,-2.1021892e-06,-0.088363364,0.05604592,0.008450675,-0.0805284,-0.032168373,0.01762409,0.020228088,0.045302667,-0.0059614736,-0.02526342,-0.022618001,-0.054034773,0.09204893,-0.0021728484,-0.011820198,0.074487075,0.020337228,0.013947215,0.006836945,0.0022055407,0.032717627,-0.022541337,-0.04791722,0.013273698,-0.063500725,-0.020960735,-0.058810037,-0.055249207,0.015744485,-0.045522954,-0.078009605,-0.04316109,-0.032012776,0.051200937,0.041859962,-0.04870698,-0.087723106,-0.00052892446,0.054885533,-0.054365333,-0.02052828,0.0477032,-0.045362614,0.040512078,0.08295545,-0.01733594,0.05094209,0.05345722,-0.109169476,0.0050204196,0.004889522,0.036279313,-0.05823931,0.07862106,0.0504625,0.028660879,-0.053526785,0.11477854,-0.041961987,-0.015599843,-0.09121017,-0.11407423,0.032507613,-0.005716699,0.004395667,-0.075642385,0.06384043,0.036337122,-0.02398917,-0.061880782,-0.023585757,-0.034085006,0.021935364,-0.010195168,-0.013308427,-0.05862603,0.00039478843,0.051316325,-0.12517476,0.060130086,0.04360447,-0.055373743,0.031326123,-0.07469411,-0.059265573,0.011465068,0.013549178,0.007334598,-0.02564135,1.5521321e-33,0.06303846,-0.105171,0.050870437,0.023642778,0.016037714,0.012404781,0.06524193,-0.043631963,0.00047223744,0.05068925,0.10172336,-0.08990734,0.044582315,-0.008159412,0.013631073,0.119157605,-0.019511713,0.09222758,-0.01047861,-0.018286727,-0.048049327,0.019959101,0.06757678,0.00018022684,-0.016126376,0.109786026,0.040633287,-0.017422134,-0.019010235,0.12606946,-0.03802616,3.4859506e-05,-0.039202824,-0.09749057,-0.04836063,0.07391717,0.03313699,-0.080479495,-0.031615958,-0.051552236,-0.02158704,0.06035329,0.047568295,0.0831301,0.05735336,0.078091465,0.06865666,0.045192424,-0.077719174,0.0247871,0.04985765,-0.003385446,-0.026806636,0.04261203,-0.0021230546,-0.035325594,-0.054684278,0.010140962,0.02073859,-0.07190309,0.0049089445,-0.044411253,-0.02901876,0.020316323,0.04303133,0.0070909723,0.055250943,0.0002216667,0.012993852,0.053631667,0.07187962,0.003722111,0.08473301,0.034254503,-0.016325478,0.061091624,-0.09036516,-0.0036078384,-0.024343872,-0.020872116,-0.13872543,-0.0472907,-0.0012624899,-0.026046768,0.003757932,-0.06989694,0.004108767,0.044538073,0.011525072,0.070402145,-0.100145556,-0.017809901,-0.10876483,0.025548488,0.10795269,-1.5884225e-08,0.10599307,-0.097497605,-0.04462177,-0.024996888,0.008672125,0.07142648,-0.055987295,-0.037740044,0.08792726,0.038308818,0.0013122464,0.023545928,-0.028097663,0.06561207,-0.10558364,-0.0015545369,-0.0034185976,0.006964595,-0.0030782025,-0.022832239,-0.04923208,0.0049612047,0.030865159,-0.051117312,-0.023750035,-0.08683482,-0.059123646,0.045329787,-0.005419769,-0.04988839,0.051295474,0.03397128,0.019149587,-0.074877255,-0.025677461,0.045382224,0.026843477,0.011043938,-0.0074152336,-0.0007326422,-0.07648497,0.009295667,-0.07664212,0.0022839224,0.024224117,-0.051332373,0.003865663,0.08682617,-0.056076396,-0.016524054,0.032266233,-0.0068192207,0.038701974,0.014858172,-0.057315037,-0.015403711,-0.048111502,-0.09907646,-0.012570321,-0.030175103,-0.040235836,0.0051033474,0.04907325,-0.06592687 +4.3.1.3,"This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23 (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [4]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [5]. This enzyme catalyses the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate [2,3].",384,1.0,0.0011417058,-0.021547407,-0.08598995,-0.10960742,0.10062666,0.051479504,0.0026634496,0.031276945,0.031694897,0.040720463,0.027025333,-0.0165149,-0.0499717,0.06351335,-0.083541654,0.039028756,-0.101524405,-0.058299564,-0.06443026,-0.11628669,0.065408595,0.04026194,-0.029669033,-0.035440445,-0.0058693714,0.0030743857,0.04819829,-0.053516157,-0.03374593,-0.048024513,-0.013688173,-0.097813144,0.070809014,-0.08042984,0.021417975,0.0445567,-0.039375745,-0.114821136,0.039488874,0.06398078,0.014051842,0.018377753,-0.021598248,-0.08655036,-0.0036616167,0.0048219287,0.032588303,-0.051662024,0.059305616,0.014779233,-0.029875748,-0.054424886,0.04303267,1.0002637e-05,-0.008226225,-0.0100202365,-0.124543615,0.0052690967,-0.031512495,0.057567637,0.034135103,0.029169664,0.043206923,-0.078235954,-0.019048097,-0.0065217665,-0.0021185381,-0.11278521,0.021757025,-0.08030187,-0.05880899,-0.10941801,0.002393704,0.025648016,-0.04487276,0.04149077,0.002031502,-0.009229583,0.03312757,-0.007433583,0.0006657492,0.005128095,0.04983882,-0.008405759,0.038946565,0.031995166,-0.009458978,-0.0075321835,0.119496934,-0.00015035903,0.058838516,-0.024077171,-0.021602841,-0.0015546071,0.03677771,0.023923866,0.018395754,0.051295422,0.002183687,-0.0012392929,0.029090017,0.07131842,-0.058891524,-0.042885218,-0.056592528,0.032102995,0.08153919,0.14185195,-0.0073941085,-0.021157045,-0.053122472,-0.0036776955,0.027230445,-0.011912352,-0.025579473,0.07391888,0.048274107,0.007185918,-0.012946349,0.011755561,0.059580117,0.016608344,0.10531333,0.057253182,-0.010077405,0.05253226,-0.12967668,1.7875212e-33,0.057264984,0.10370838,0.029488621,-0.0016367268,-0.027284821,-0.011491902,-0.05431056,0.08040381,0.01416045,-0.09550577,-0.11512838,-0.022629254,0.031520627,-0.082810044,-0.10020056,-0.0057677273,-0.024748728,-0.02517111,0.06652367,0.018731698,0.034434654,0.11713266,-0.016540328,-0.0012101821,-0.012844667,0.014301163,0.04669283,-0.05939737,0.027116459,0.011765171,-0.09685182,-0.054999944,-0.111439995,-0.042700976,0.013230022,-0.002929135,-0.05658303,0.010530134,-0.011996356,0.06837237,-0.00045102127,0.01591414,0.029879285,-0.03373691,0.041526366,-0.016888358,-0.031731296,0.046096254,0.022289151,0.018891009,0.0073603624,-0.044093344,0.06541019,0.01737952,-0.11453445,0.0005989283,-0.02479059,-0.021856084,0.05894206,0.07757281,-0.019781722,0.026879733,-0.018504648,0.0620184,0.02962299,-0.025610887,-0.05676372,-0.04450534,0.030465089,0.08119842,-0.04967091,-0.048649803,0.079675026,0.029292354,0.01993356,-0.116612904,-0.057542372,0.015738714,-0.02522381,0.0020830429,-0.01244724,0.031735066,0.010807141,0.021143682,-0.03103587,-0.0033320247,0.012794455,-0.03631266,-0.0133410515,0.03945501,0.02866207,-0.08851029,0.004790195,0.020598093,-0.022260116,-2.6822772e-33,0.11839183,-0.11597421,0.03201996,-0.07262782,-0.051164355,0.032608572,0.070944995,-0.0020089494,0.0121265305,-0.017274037,0.07628958,0.0054915887,0.071457356,-0.04899502,-0.024746977,0.019995766,0.025833946,0.046079237,0.013870235,-0.025906906,0.003614159,0.015728686,0.048130624,0.013117986,0.05602084,0.022421377,0.025758207,0.010329505,0.07849155,0.030961994,-0.04579632,-0.013509763,0.008776746,-0.06497148,0.0013826608,0.06292918,-0.05097985,-0.060814958,0.030581662,-0.023955802,0.015498301,-0.0018094432,0.030609077,0.041202806,-0.017761853,0.08041874,-0.102598354,0.054184593,-0.004496343,-0.051845144,0.014127093,-0.052704223,-0.04341476,-0.034008343,0.0023222028,0.059314203,0.029398987,0.041449733,-0.09486823,0.12554035,0.0073042917,-0.031456795,0.059835475,0.009017123,0.043050807,0.01312938,-0.01744373,0.035283953,0.046117067,0.02763309,0.031360224,-0.036346167,0.04231381,0.06633003,0.008363306,-0.054569595,-0.03408114,-0.010499575,0.027755188,-0.08903634,0.010694844,-0.077131264,-0.003725532,-0.04868506,-0.00021185138,-0.08501827,0.07783726,0.15377155,0.0052230847,0.015274936,0.018331984,-0.009986906,-0.06914422,0.09844491,0.023440214,-4.6801578e-08,0.04455343,-0.09463176,0.038252376,-0.041981317,-0.06874557,0.09007128,0.02182838,-0.0007801035,0.047041528,-0.0683723,0.06659168,0.046592057,-0.043777946,0.017264271,-0.034758184,0.028667707,-0.099277005,0.06194706,0.021222722,0.0010195234,-0.056767818,-0.02941684,-0.10478508,-0.04841693,0.017398957,-0.016473927,0.040138166,0.11385137,-0.006433737,-0.050418563,-0.012743397,-0.0025828173,0.0392174,-0.009708249,-0.06342135,0.037021507,-0.043469906,-0.015070636,-0.04927018,0.009406262,0.0002065475,0.021627292,-0.07472528,-0.0074234414,0.022532212,-0.0050644036,-0.029105842,0.04840247,-0.022729713,0.0018498607,0.009977892,0.0028958588,0.023896085,-0.005101685,-0.052451745,-0.015098866,0.000607992,-0.09544402,0.054791313,-0.070263386,0.018813074,0.01968222,0.13400553,0.034159254 +4.3.1.4,"In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.",384,1.0,-0.03256073,-0.029281616,-0.065737754,-0.023790546,-0.047563788,0.004884031,-0.018211052,0.076257706,0.028379133,0.022278247,0.07288411,-0.1262246,-0.11725404,0.005170594,0.045199048,0.044225708,-0.071750015,-0.014020657,-0.037751224,-0.026664676,0.09115532,0.07916768,-0.050824367,-0.020621099,0.004173721,0.035966605,0.074851006,-0.023432586,0.053067744,-0.0817735,-0.029542604,-0.07349399,0.10750523,0.02487266,0.031370845,0.059084225,-0.10204979,-0.13087682,0.045991905,-0.075082496,0.07245711,0.028331473,-0.00882989,-0.024796413,-0.022620048,0.053333774,0.05549098,-0.03108049,-0.0005233678,-0.027269829,0.034212686,-0.045807917,-0.019489931,-0.018267393,0.034879375,-0.016127128,-0.042650502,0.014796138,0.058168873,0.030436002,0.055569105,0.014645097,0.027204148,-0.008807936,0.020539133,-0.045896728,0.098182455,-0.05306731,0.0037888205,-0.040141635,-0.04614395,-0.055530816,-0.0021228818,0.07727203,-0.034281086,0.064899154,-0.011386915,-0.023725724,-0.0080912,-0.019104952,0.0027675394,-0.041321356,0.059329703,-0.021798765,-0.00048234177,-0.017212356,-0.0035520238,0.021639336,0.015001736,0.035875402,0.018656055,-0.012139299,-0.03141452,-0.004266252,-0.060393475,0.018521225,0.07056885,0.0870698,0.06576874,-0.05247305,0.027801491,0.14955093,0.022122804,-0.0123630725,-0.022931648,-0.03891587,0.04044391,0.034336954,0.03549289,-0.0070464774,-0.053827465,-0.0329812,0.08638131,-0.003540689,-0.023584265,0.022817355,0.010168629,-0.04438071,0.0040004025,0.11553106,0.061912406,-0.009592315,0.038702376,0.07436176,-0.027098676,0.010108949,-0.1144422,9.294689e-34,0.05381657,-0.0057041463,-0.0023184465,0.016211793,-0.005852652,-0.015333898,-0.121581115,-0.038292263,-0.01204183,-0.09663594,-0.111068726,-0.035831235,0.067270175,0.09118737,0.0002889035,0.00071454595,-0.041694827,-0.014528628,0.07504155,0.02336973,0.038952604,-0.0349095,-0.04272161,0.005478662,-0.029459013,0.030362092,0.012135615,0.015966391,0.027162831,-0.0014751409,-0.05177223,-0.16309592,-0.10638853,0.031666342,0.032357484,0.021020748,0.0640999,-0.05075719,-0.024098901,0.009626604,0.025282022,-0.052381475,-0.019919863,-0.009719911,0.07923895,-0.093231,-0.05107151,0.102800116,0.07235785,0.03409217,-0.021756273,-0.10400909,0.12646553,-0.004866901,-0.005942721,0.0687713,-0.021641564,-0.06528533,0.04597078,0.06272304,0.0076968377,0.072957225,-0.050046302,0.025969636,0.02384886,0.028672775,-0.032335687,-0.06230537,-0.009142986,0.012643854,-0.028303066,-0.07267551,0.14998995,0.041176576,-0.0128679415,-0.05239663,-0.079177156,0.0016869904,-0.04547738,0.06758608,-0.049969554,-0.032146428,0.0105802575,-0.06584806,0.038017645,0.016741818,-0.020510359,-0.07974745,-0.030970331,0.049213678,0.041035455,-0.04588366,-0.08347172,-0.015085181,-0.0037061616,-3.2155637e-33,0.0699919,-0.032602556,-0.05150633,-0.05061206,0.011688191,0.051476818,0.0052248742,-0.014390399,-0.0046244026,-0.034802347,0.043231472,-0.016724376,0.09937802,-0.06595145,-0.0031747827,0.0071113016,0.0067979605,0.12118821,0.0614168,-0.041218564,-0.017525941,0.009155109,0.014783224,0.04298123,0.068418466,0.006826895,-0.021627668,-0.0048401016,-0.044331748,0.046677135,-0.06962538,0.028152011,-0.021329338,-0.0012249401,-0.02502131,0.012195078,-0.02635787,-0.022907631,-0.009168291,0.0018153487,0.001709094,0.06877358,0.03003801,0.043515738,0.015459497,0.081417635,-0.010488523,0.04914949,-0.033903997,-0.053349208,0.033014577,0.038925793,-0.029857429,0.0024522436,0.012707348,0.05158441,0.047726616,0.00854325,-0.04962892,0.024922937,-0.055451028,-0.056894533,0.0547271,-0.016893089,0.043299858,0.024887746,-0.029209645,0.057785913,0.021361284,0.008820197,0.04919987,-0.035737816,-0.029728483,-0.01027781,-0.02853988,-0.007334795,-0.07724699,-0.027450548,0.025627859,-0.08665276,0.04017565,-0.03272457,0.03583695,-0.061818082,-0.04556043,-0.111613505,-0.04263737,0.07400621,-0.031614795,0.003006615,-0.068833634,-0.05511358,-0.029048355,0.078211285,0.05761682,-3.4935162e-08,0.00038908966,-0.0016760326,-0.0013850471,-0.06616482,0.05548981,0.04554509,-0.032970563,0.027115004,0.033215553,-0.014762833,-0.028320674,-0.007628279,-0.043941986,0.014531919,0.020829052,0.06709109,0.0200915,0.070605986,-0.0222204,-0.00034426968,-0.046858527,-0.05337669,-0.043152638,0.03732922,0.022618726,-0.028806482,0.030162727,0.07499166,0.0015982466,-0.036409907,-0.05100253,0.03853651,-0.015358119,-0.040652614,-0.07683339,0.027715806,0.042617977,-0.028949922,-0.07073209,0.062381476,-0.022652267,-0.04266415,-0.081221506,-0.0059088934,-0.00037046292,0.07688176,0.031348195,0.0963115,-0.035395198,-0.10105357,0.045667656,-0.018210297,0.017142626,-0.025567302,-0.11420031,0.016444815,-0.029742617,-0.04255738,0.06315652,0.024180539,0.029319499,0.104381934,0.18854524,-0.03586977 +4.3.1.5,"This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase) and EC 4.3.1.5 (phenylalanine ammonia-lyase). The enzyme from dicotyledonous plants efficiently deaminates L-phenylalanine, whereas that from some monocots, including maize, and from the yeast Rhodosporidium toruloides can also deaminate L-tyrosine [3]. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. The substrate specificity of the enzyme can be switched from phenylalanine to tyrosine by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides [6].",384,1.0,-0.031929836,-0.047287602,-0.06746982,-0.07920353,0.15366222,0.03527783,-0.03368642,0.0012204684,0.039795812,0.04220298,0.1068138,-0.041572258,-0.08780919,0.030033488,-0.042132597,0.06885388,-0.0806545,-0.043404527,-0.04662645,-0.0672927,0.06406442,0.06740263,-0.04658365,0.01459676,0.021141993,-0.06843326,0.04539722,-0.043355178,-0.07819416,-0.05429809,-0.027033053,-0.061965685,0.062437765,-0.049990676,-0.007916558,0.056338515,-0.04482427,-0.119912975,0.07732332,0.07152063,-0.010153098,-0.009691197,0.014218392,-0.09921629,-0.06490951,0.020213742,-0.008017776,-0.0007723452,0.047307093,-0.03152255,-0.0061153164,-0.038153708,0.052188393,0.0018067823,-0.062235985,-0.0207484,-0.03869811,0.07996675,-0.040359497,0.07162617,0.013587316,0.05094666,-0.0032113583,-0.045550514,-0.07479927,-0.02327521,-0.006414779,-0.0977889,0.046656586,-0.06630875,-0.028811838,-0.118522346,0.03005097,0.007309637,-0.009515228,0.07840965,0.03140735,0.021472478,0.04241256,-0.029383613,-0.0001996332,0.026604634,0.04639422,-0.029106827,0.024681024,-0.0074006035,-0.04641963,0.05030326,0.11555973,-0.027059412,0.07126909,-0.005450666,-0.048361186,0.007561852,-0.020087548,0.047681455,0.0490353,0.011457794,-0.030076804,0.010295212,0.0043165516,0.037262183,-0.06922997,-0.044592015,-0.081766665,0.03340145,0.05167981,0.06892784,0.0015652865,-0.051614624,-0.00065076735,0.014669257,0.026220715,0.0014391638,-0.037840303,0.010636514,0.06690025,-0.025294868,-0.043378707,0.013888343,0.036460433,-0.01007204,0.10413872,0.060380246,-0.03303373,0.06751082,-0.1254693,2.3423292e-33,0.060605146,0.053201847,-0.014413816,-0.016385196,0.018158171,-0.022851394,-0.054661263,0.093652196,0.01842736,-0.104418956,-0.11146124,-0.052176684,-0.0074560833,-0.06355445,-0.060043126,0.03408551,-0.014475487,-0.011854753,0.06254377,0.07005076,0.014427178,0.06386927,-0.07455181,0.021049457,0.008416596,0.042265546,0.011701757,-0.10059386,0.020711785,0.0030417747,-0.024895139,-0.093820214,-0.08212607,0.011057149,0.0025322684,-0.0038026574,-0.06733399,-0.023431316,-0.009297984,0.017884605,0.00089376216,0.03476227,0.034159865,-0.013538809,0.041162085,0.01975889,-0.0040301657,0.024505628,0.013774825,0.028490402,0.058960002,-0.023404943,0.061238125,-0.0043460517,-0.07196676,-0.013798098,-0.0001283883,0.041998185,0.08945797,0.06558922,0.008527711,0.08051303,-0.009322177,0.055652294,0.02150623,-0.044227544,-0.04045045,-0.027468033,0.022054305,0.05762412,-0.054147247,-0.09977641,0.07809617,0.042417355,0.01726772,-0.12353725,-0.033962827,-0.0022747177,0.011149528,0.0099547235,0.039103717,-0.024640363,0.03819006,-0.028389545,-0.04626685,-0.026544014,-0.02408128,-0.03745124,-0.015875833,0.039021455,0.056388143,-0.06466477,0.0016704643,0.025837587,0.021144854,-3.1114726e-33,0.09530382,-0.08231302,0.034402784,-0.10086033,-0.05451557,0.051967096,0.04630484,0.00036236783,0.014040441,-0.075986214,0.09011455,-0.01438856,0.00912575,-0.015666528,-0.011672585,0.021183796,-0.011241462,0.065925755,0.015538744,-0.0042354376,-0.047853608,0.017009115,0.04414597,0.0073492173,0.104191504,-0.0028638395,-0.01373478,0.0890964,0.03511845,-0.0047515593,-0.06410783,0.032865413,0.029134374,-0.046586804,0.00704273,0.0316914,-0.08495769,-0.05813882,0.06355687,0.042064797,-0.013825797,-0.02413546,0.012576367,0.025529658,-0.05531534,0.07825999,-0.116093464,0.0036220013,0.008388883,-0.027723517,0.003138786,-0.003853252,-0.026665663,-0.020722738,-0.013175162,0.047590654,-0.0044687395,0.04367798,-0.0636349,0.07405566,0.0009323317,-0.05900702,0.0006114074,0.07987391,0.04514689,0.05815666,-0.007835556,0.06574061,0.052500937,0.0014564574,0.04135946,-0.02352104,0.08691712,0.07406412,-0.0417868,-0.058313724,-0.022529535,-0.043130413,0.014939333,-0.077988505,0.030168427,-0.066485435,0.017639497,-0.033720158,-0.0017026287,-0.083347596,0.048804272,0.09812593,-0.006975891,0.014303993,0.06630863,-0.02596812,-0.034644533,0.06823145,0.1163526,-4.7471268e-08,0.05291511,-0.103579536,0.03426993,-0.06863845,-0.017365979,0.014654363,0.042580258,0.017886134,0.006848547,-0.034506205,0.014656593,0.062244438,-0.06255515,0.022436716,0.026379654,0.0049194014,-0.08536462,0.060637034,-0.0018808191,0.08805916,-0.031968765,-0.018751327,-0.14889592,-0.028379416,0.012635444,-0.014935052,0.029717948,0.10515609,0.06204565,-0.028580584,0.0046833595,-0.018754968,0.0055944314,0.010221028,-0.07924289,0.034028124,-0.089340135,-0.04166484,-0.074143134,0.010668569,0.011404653,0.017539063,-0.06312778,-0.020844895,0.0125312675,-0.023820067,-0.023121506,0.065562025,0.021922303,0.023559455,0.011268056,-0.00759186,0.025120726,-0.02952916,-0.080841914,-0.026908793,0.016412642,-0.0127811,-0.008794651,-0.058956854,-0.012444359,0.036626134,0.17488885,0.0085033495 +4.3.1.6,The reaction has only been demonstrated in the direction of addition of ammonia.,384,1.0,-0.033294152,0.036856167,-0.026679687,0.0062800283,0.05653235,0.014055333,-0.07867446,-0.04157882,0.029065825,0.04873735,0.030351283,-0.05145434,-0.04049737,-0.0008941918,-0.09940484,0.016590657,-0.027898282,-0.098414674,0.026100263,-0.015864305,-0.029901084,-0.048222017,0.047134884,-0.015813394,0.033552438,0.11321925,-0.016887615,0.04447904,0.04937605,-0.07140768,-0.04932904,0.013754879,-0.031418767,-0.02630522,0.033613168,-0.0131906,0.00035449883,0.080472074,0.01235983,-0.011389776,0.0065498953,-0.034539126,-0.0241038,-0.04539824,-0.018049212,0.04199359,0.09306272,-0.078325495,0.026029699,-0.01121948,-0.00036569464,-0.010356407,-0.02496612,-0.011928563,0.036145017,-3.4846948e-05,-0.1004099,0.08164811,-0.050867595,-0.043360006,0.02435713,-0.017234901,0.013782697,-0.024407383,0.05496269,-0.0050680884,-0.074658476,-0.030570727,0.015212955,0.0107290605,0.031698626,-0.029445183,0.0024815518,-0.079282366,-0.01666615,-0.026736768,0.0011030216,-0.024774676,0.049811997,0.030131722,-0.022026481,-0.023190664,0.036565915,-0.0060769003,-0.015577186,0.12203047,-0.04927984,-0.019836139,0.023895945,-0.025480893,-0.019264964,-0.0015454208,0.020080034,-0.06430293,0.05471361,-0.005247692,-0.006012856,0.039301928,0.0029777226,-0.023967694,0.012594832,0.0058374507,-0.037863497,-0.07439308,-0.00082544837,0.05308904,0.027481912,0.04553743,0.023481755,0.06157214,-0.006426559,0.043564793,0.09315852,0.020648984,-0.09112905,-0.004364498,0.0029315695,-0.020439893,-0.13551667,0.007293383,-0.0011155003,-0.036180872,0.007493969,0.08710053,-0.029817145,0.0641622,-0.030083884,-3.8975705e-33,0.027077818,-0.008745055,0.06746784,-0.07594003,0.0074919164,0.04853722,0.0056319325,0.006312557,0.07122252,-0.049047954,-0.019436235,-0.015283789,0.031655982,-0.08128732,-0.11576638,0.059401643,0.039584596,0.030938447,0.0054483362,0.015713891,-0.028491024,0.07969883,-0.08223732,0.019071484,-0.03245604,-0.050031222,0.044653606,-0.07006833,-0.023561217,-0.042711608,-0.04283443,0.026267769,-0.112631045,0.04910955,-0.015298485,0.03817937,-0.041005857,-0.0047073243,1.8514631e-05,0.016081378,-0.02283994,0.031785384,-0.06347085,-0.06660705,0.04801572,-0.017977009,-0.03181625,0.062187105,0.030906491,-0.0030476814,-0.0021310996,0.040351838,-0.028075363,-0.0050357287,0.016250454,0.052240927,0.050765473,-0.012828098,-0.053566266,0.028711567,-0.028521985,0.055139843,-0.05996769,0.024506511,-0.06163196,0.049691495,-0.10760136,-0.04432944,0.03762478,0.022398826,-0.026338521,0.041740038,0.035165288,0.008854493,-0.0011383349,-0.069654346,-0.014364501,0.015573866,0.09414849,-0.026021475,0.070470735,-0.03629676,0.013980797,0.02785521,-0.022810474,-0.022203056,-0.0425332,0.05615473,0.02339344,0.08207875,0.051830627,-0.07045499,-0.07083035,-0.016075542,0.024266567,1.6975889e-33,-0.04819731,-0.008984421,-0.061918877,-0.048512742,-0.08364006,0.07264481,0.04944372,-0.029420888,0.0039482997,-0.01255203,0.22587717,-0.0019356218,-0.074238814,0.095150605,-0.052066274,0.057219822,-0.046165153,0.10727184,0.06700052,0.0058197933,-0.009234789,0.059257224,-0.052144207,0.08107183,0.02642059,-0.017976264,0.07586323,0.024286246,-0.020662181,0.012506425,0.036819663,0.014742552,-0.08014958,-0.08298191,0.03695121,-0.047038034,0.030256161,0.0034685712,-0.039817523,-0.025188133,-0.0134067945,-0.057246942,0.04154443,0.07340839,0.013303262,0.047399227,-0.021980772,-0.052970637,0.008771578,-0.015086374,0.02801681,0.029077435,-0.05240225,-0.076157585,0.029714772,0.046018377,0.031782415,-0.0031911999,0.044823468,-0.020825218,0.024913136,-0.0041637216,-0.00896516,-0.1492489,0.001686269,0.07125133,0.017672587,0.11522672,0.091320984,-0.049937177,0.15086375,0.082194485,0.09985495,-0.010172253,0.016507195,0.018292809,0.052953035,-0.075262144,0.02401363,-0.11077125,-0.09215811,0.005028674,0.03465932,-0.089521185,0.064494245,0.009530542,0.06726521,0.02411468,-0.09215395,0.078671835,0.008385761,0.008561933,0.029138315,0.04768748,0.05094845,-1.8251704e-08,0.013248498,-0.09178022,0.043946046,-0.00829399,-0.03369086,0.10758603,0.07176171,-0.02651517,-0.0572232,-0.054458123,-0.004236053,0.102181956,-0.01705118,0.06345874,0.08494361,-0.0014380356,-0.017317263,-0.11632448,-0.036808327,-0.0549945,-0.09417412,0.06021624,-0.054400332,0.0071230717,-0.03179018,-0.030689707,0.07317764,-0.029931122,0.029928198,-0.1110279,-0.017652534,0.00028102074,-0.01620282,-0.00895809,-0.011471637,-0.020190585,0.02133411,0.11628818,-0.060098365,-0.028914709,-0.089204274,0.0051849056,0.0020886161,0.012215105,0.017867846,0.0392553,-0.026119823,-0.05244549,-0.040234655,-0.012643589,0.035386056,0.053925596,0.06190994,0.040304206,-0.025055835,0.09936216,0.0041311528,-0.03674949,-0.009139931,0.06199182,0.07611211,-0.015873887,0.02510538,0.032224156 +4.3.1.7,A cobalamin protein.,384,0.99999994,-0.06870766,0.011437994,-0.11470438,-0.015760722,-0.047259904,0.049371425,0.059385505,0.038116183,0.058374066,-0.04834327,0.023236334,-0.09614474,0.011807483,0.014048942,-0.015276668,-0.0347884,0.0831031,-0.016098255,-0.06860744,-0.1136095,-0.06596166,0.08337052,-0.025793606,0.017544555,-0.018330263,0.01728738,0.020980109,-0.022479344,0.020105243,-0.02608002,-0.025836656,-0.0019247843,0.039165497,0.029491229,-0.0689073,0.06621256,0.025095975,-0.04355875,0.06407768,0.0007071942,0.053661507,0.07740956,0.031768646,-0.015974537,0.037579883,0.025917744,0.016453775,0.09465446,0.07160023,0.054680023,-0.07774146,-0.09470757,-0.037391625,0.045029566,-0.018389523,0.013400241,-0.08666109,-0.0112543255,0.013343187,0.026724502,-0.02423042,-0.04876207,0.06788585,0.03500842,0.08970227,-0.055710386,0.0073686447,-0.0012968555,0.055426672,-0.018645257,0.07581937,-0.018050747,-0.012890211,0.016244598,-0.03697361,0.045356844,-0.0582229,-0.05937572,0.01966747,0.01217623,-0.0071156523,0.03684094,-0.0028222976,0.13026229,0.051442463,-0.06395132,-0.019168127,0.069859155,-0.03920627,0.022880925,-0.014237379,-0.0009507272,0.053000543,0.018072948,-0.0883744,0.022236127,-0.006388339,-0.01703426,-0.052769244,0.011750771,-0.031539068,0.047656458,0.07396142,-0.0050795665,-0.010104141,-0.0525953,0.03578527,0.12107159,0.010763601,0.000810065,0.0077444045,-9.5077405e-05,-0.01203443,-0.039566293,0.004901102,0.054528233,0.08294189,-0.0108835,-0.11312781,0.033119727,0.026859382,-0.008749201,0.007591337,-0.027437253,-0.043196082,-0.028235545,-0.03901976,-3.8345614e-33,0.061286546,-0.035993066,0.0558929,0.059935816,0.016886229,-2.1021892e-06,-0.088363364,0.05604592,0.008450675,-0.0805284,-0.032168373,0.01762409,0.020228088,0.045302667,-0.0059614736,-0.02526342,-0.022618001,-0.054034773,0.09204893,-0.0021728484,-0.011820198,0.074487075,0.020337228,0.013947215,0.006836945,0.0022055407,0.032717627,-0.022541337,-0.04791722,0.013273698,-0.063500725,-0.020960735,-0.058810037,-0.055249207,0.015744485,-0.045522954,-0.078009605,-0.04316109,-0.032012776,0.051200937,0.041859962,-0.04870698,-0.087723106,-0.00052892446,0.054885533,-0.054365333,-0.02052828,0.0477032,-0.045362614,0.040512078,0.08295545,-0.01733594,0.05094209,0.05345722,-0.109169476,0.0050204196,0.004889522,0.036279313,-0.05823931,0.07862106,0.0504625,0.028660879,-0.053526785,0.11477854,-0.041961987,-0.015599843,-0.09121017,-0.11407423,0.032507613,-0.005716699,0.004395667,-0.075642385,0.06384043,0.036337122,-0.02398917,-0.061880782,-0.023585757,-0.034085006,0.021935364,-0.010195168,-0.013308427,-0.05862603,0.00039478843,0.051316325,-0.12517476,0.060130086,0.04360447,-0.055373743,0.031326123,-0.07469411,-0.059265573,0.011465068,0.013549178,0.007334598,-0.02564135,1.5521321e-33,0.06303846,-0.105171,0.050870437,0.023642778,0.016037714,0.012404781,0.06524193,-0.043631963,0.00047223744,0.05068925,0.10172336,-0.08990734,0.044582315,-0.008159412,0.013631073,0.119157605,-0.019511713,0.09222758,-0.01047861,-0.018286727,-0.048049327,0.019959101,0.06757678,0.00018022684,-0.016126376,0.109786026,0.040633287,-0.017422134,-0.019010235,0.12606946,-0.03802616,3.4859506e-05,-0.039202824,-0.09749057,-0.04836063,0.07391717,0.03313699,-0.080479495,-0.031615958,-0.051552236,-0.02158704,0.06035329,0.047568295,0.0831301,0.05735336,0.078091465,0.06865666,0.045192424,-0.077719174,0.0247871,0.04985765,-0.003385446,-0.026806636,0.04261203,-0.0021230546,-0.035325594,-0.054684278,0.010140962,0.02073859,-0.07190309,0.0049089445,-0.044411253,-0.02901876,0.020316323,0.04303133,0.0070909723,0.055250943,0.0002216667,0.012993852,0.053631667,0.07187962,0.003722111,0.08473301,0.034254503,-0.016325478,0.061091624,-0.09036516,-0.0036078384,-0.024343872,-0.020872116,-0.13872543,-0.0472907,-0.0012624899,-0.026046768,0.003757932,-0.06989694,0.004108767,0.044538073,0.011525072,0.070402145,-0.100145556,-0.017809901,-0.10876483,0.025548488,0.10795269,-1.5884225e-08,0.10599307,-0.097497605,-0.04462177,-0.024996888,0.008672125,0.07142648,-0.055987295,-0.037740044,0.08792726,0.038308818,0.0013122464,0.023545928,-0.028097663,0.06561207,-0.10558364,-0.0015545369,-0.0034185976,0.006964595,-0.0030782025,-0.022832239,-0.04923208,0.0049612047,0.030865159,-0.051117312,-0.023750035,-0.08683482,-0.059123646,0.045329787,-0.005419769,-0.04988839,0.051295474,0.03397128,0.019149587,-0.074877255,-0.025677461,0.045382224,0.026843477,0.011043938,-0.0074152336,-0.0007326422,-0.07648497,0.009295667,-0.07664212,0.0022839224,0.024224117,-0.051332373,0.003865663,0.08682617,-0.056076396,-0.016524054,0.032266233,-0.0068192207,0.038701974,0.014858172,-0.057315037,-0.015403711,-0.048111502,-0.09907646,-0.012570321,-0.030175103,-0.040235836,0.0051033474,0.04907325,-0.06592687 +4.3.1.9,"Contains pyridoxal phosphate. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes spontaneous hydrolytic deamination to form the final product.",384,1.0,-0.0047111292,-0.05487488,-0.01577619,-0.047101352,0.08415549,0.0009601785,0.060425546,-0.003691798,0.007592116,0.08660772,0.026706027,0.005548572,-0.04377293,0.04161333,-0.030524798,0.08969874,-0.07281113,-0.027591037,0.014628097,-0.032325596,0.109812714,0.044585746,-0.004380471,0.06418174,-0.016020954,0.08183571,0.095577374,0.007195889,0.02311894,-0.076419346,-0.023556815,-0.006020262,0.003131293,-0.109573625,0.07970062,0.111346185,-0.095587276,0.01898102,0.0070041963,-0.028929614,0.04397827,-0.04855347,-0.04497941,-0.014550868,-0.03187982,-0.011984003,0.048627686,0.026167655,0.010947993,0.04007541,-0.04077751,0.01358264,-0.02282252,0.029228384,-0.015419007,-0.0014858383,-0.023498747,0.04969632,-0.09586298,0.03718264,0.044223312,0.025052065,-0.057542413,-0.009082826,0.08054353,-0.018408213,0.0633056,-0.03687385,-0.021795914,-0.06390505,-0.0076889163,-0.06621469,0.024631843,-0.0074544703,0.016286064,-0.003013304,-0.0020258157,-0.026820578,0.026777033,0.08275058,0.016217425,-0.007880354,0.041280553,0.074369505,0.06609877,0.04032059,0.036550835,-0.0100678345,0.0072723557,-0.03651668,-0.017522354,-0.017387679,-0.044745885,-0.02094046,0.030190827,0.01011578,-0.00051327137,0.005593582,0.051598776,-0.0023761864,-0.01762689,0.03889201,-0.05192874,-0.1013083,-0.086518005,0.0024893587,0.026967162,0.039801795,0.03275441,0.057494335,-0.093974255,0.013055037,0.04073772,0.0897914,0.011169308,0.093934014,0.05970276,0.02201015,-0.05610818,-0.031162897,0.03838353,0.0017165982,0.043369193,0.123927645,-0.09872691,0.04337087,-0.07033296,1.6769376e-33,0.01816735,-0.002144186,0.038770895,0.0071085105,-0.08124346,0.025874801,-0.08157458,0.046029516,-0.04711256,-0.0060016923,-0.06645837,-0.05144419,0.07334869,0.035158224,-0.024003787,-0.096172005,-0.050638624,0.041205797,0.11887756,0.023474593,0.020731298,0.117298834,-0.060029846,0.065019034,-0.08354096,0.04701926,-0.0067435834,0.034392133,0.008278116,-0.039202817,0.06335003,-0.07766062,-0.101905905,-0.013819753,0.026874319,-0.021031534,-0.07461683,-0.018834034,0.010601421,0.056193683,-0.038810894,-0.006726103,0.009151499,-0.0043455143,-0.0055902964,-0.10816771,-0.051583737,0.034197953,0.018451842,0.00082789914,0.059708495,-0.022714935,0.05513594,-0.042380337,-0.1247578,-0.019682033,0.019673832,-0.05654069,0.019883834,0.055291127,-0.0035202787,-0.021580366,-0.039993465,0.019926043,-0.004766796,-0.039493363,-0.0002140962,-0.06185969,0.0330283,0.039971568,-0.083868526,0.043922,0.05012959,-0.013266616,0.011137135,-0.04403607,-0.07141869,0.048350904,0.00010707781,0.028399467,-0.0020934509,-0.102292866,-0.033843137,0.03565412,-0.012335489,-0.029924445,0.0044361707,-0.07280535,0.007469481,0.05420917,0.014517543,-0.11948815,-0.0690181,0.015050446,0.04540604,-3.0353577e-33,0.083270855,-0.059850756,0.01622193,-0.05173462,-0.035317488,0.04765843,0.08138117,0.003089325,0.026862487,-0.038012974,0.04961294,-0.01877276,0.010952247,-0.009540669,-0.035879944,0.023132967,0.03626665,0.06879555,0.073130615,-0.017587718,0.03138619,0.0620694,0.025589554,-0.005691308,0.05356821,0.06369663,-0.0022692543,0.06445175,0.05647881,0.06250223,-0.02384202,-0.027245577,-0.026893837,-0.031834178,-0.07749199,0.05478418,-0.063820094,-0.073147275,-0.043430276,-0.034741048,0.020225752,0.06314716,0.032813795,0.06486323,0.026559573,0.054037407,-0.042290494,0.060189296,-0.04106834,-0.01241232,0.078943625,0.057191495,-0.03774699,-0.02432479,0.04614804,-0.0076205325,-0.06174162,-0.007030577,-0.034263194,0.0038340797,-0.02971799,0.021141766,-0.01638331,-0.017236417,0.02553798,-0.012254182,0.010505331,0.03397813,0.01806119,0.0054156138,0.04738407,0.024869522,0.0488571,0.04835244,0.00041545983,0.011310305,-0.081141844,-0.06622762,0.036741592,-0.117016725,0.009373452,-0.01809851,-0.032650754,-0.08211125,-0.0075330343,-0.048383,0.021616334,0.007857821,0.022517731,0.014671007,0.032636408,-0.009295984,-0.017962368,0.07154243,0.08260581,-3.6557086e-08,0.058953576,-0.10611539,0.011199613,-0.03792565,-0.009522153,0.028708138,0.098184615,0.031629227,0.06675455,-0.07361303,-0.0039588804,0.0141837,-0.014392299,0.004581969,0.04471907,0.045889545,-0.037097044,0.07990039,-0.044803914,-0.097089455,-0.10855122,-0.04956229,-0.14146304,0.0453008,-0.0007546779,-0.018455513,-0.025098484,-0.0007953892,-0.0060359333,0.006553951,0.056875367,-0.004654868,0.030192755,-0.07804932,-0.07544321,0.10215785,-0.033885963,-0.031233918,-0.019936556,-0.0333532,-0.07109781,0.019954592,-0.061579954,-0.038415927,0.012574363,0.0060991636,-0.046450675,-0.010251998,-0.0048392187,0.013340343,0.029848106,-0.021490678,-0.004458407,-0.075554885,-0.11699932,0.02373507,0.0005497044,-0.07905047,0.0697712,-0.08095369,-0.0049352357,0.037277564,0.22758983,-0.052585408 +4.3.1.12,Requires NAD+. The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2].,384,1.0,-0.06472992,-0.02654419,-0.0036302935,0.00084137416,0.08382456,0.030472979,-0.022247586,0.016258217,0.04685759,0.017452223,-0.0020251346,0.0039504203,-0.060614847,0.08420857,-0.021304118,0.08187487,-0.05080995,0.038192693,0.02945925,-0.036834206,0.12089611,-0.016184257,0.05157578,-0.030567722,0.0327294,-0.0067619225,0.01696479,0.045047186,0.076390974,-0.03437405,-0.051992346,-0.019814212,0.014333358,-0.032951068,-0.027982749,0.07180551,-0.057205986,-0.0779962,-0.068336755,-0.01138695,0.048564773,0.03906007,-0.047486637,0.0069397865,-0.049736932,-0.065948226,0.05564927,0.010988553,0.018923402,0.039324585,-0.05410583,0.009390922,-0.014265238,-0.023371983,0.04209804,0.012130402,-0.08737081,0.0025026933,-0.0048297537,-0.055301197,-0.022382317,-0.04494664,-0.0047911517,0.002763905,0.071726225,-0.031696603,0.04643853,-0.010825309,-0.01588298,-0.06487027,-0.0728648,-0.017170137,-0.0007347975,0.03916625,-0.026430823,0.03668976,-0.053096622,-0.058228403,0.04695672,0.035724867,-0.018122656,-0.007035105,-0.03059155,0.07426616,0.08463347,0.04039322,-0.01688629,0.046408318,-0.026345087,-0.021110775,0.0053737327,-0.049066912,-0.06954126,0.02852441,-0.035404284,0.03772195,0.041900907,0.0026270677,-0.05732188,-0.010729918,0.004565601,0.09787556,0.016416874,-0.027941594,-0.043273367,-0.031433906,0.022374071,0.06037301,-0.079274364,0.010471301,0.026812049,-0.00447256,0.05518604,0.0011855679,-0.014024301,0.080550544,-0.034954093,-0.04761266,-0.05002218,-0.023251044,0.006031013,-0.008917976,-0.07476724,0.07505912,-0.061973386,0.028987553,-0.103888944,-2.7775183e-33,0.05332196,0.04898087,-0.002441386,0.0378221,-0.0153525295,0.012195465,-0.069316745,0.017990256,-0.060584124,-0.019856786,-0.015704665,-0.121085204,0.09496374,-0.0117628,-0.008865015,-0.023644887,0.046489276,-0.08591218,0.058399245,0.037054658,0.018259432,0.05600797,-0.04838178,0.061789565,-0.015696598,0.061008316,-0.050084166,0.020826463,0.03771277,0.0012276912,0.008276685,-0.087656714,-0.116071574,0.02245741,0.057566833,-0.04859644,-0.040288143,-0.03386891,0.04720006,-0.0054347254,-0.06200281,0.005405407,-0.034224793,-0.008232802,0.093722224,-0.08678992,0.012650073,0.0627454,0.027783306,0.06550985,0.07735312,-0.08073219,0.061420403,-0.009175034,-0.08373516,0.012228941,-0.058438197,-0.054952085,-0.014608665,0.08967284,0.03269303,-0.058995415,-0.041585274,0.07344251,-0.03400967,0.06083078,-0.123238444,-0.07546806,-0.021430714,0.08101976,-0.024283927,0.006914789,-0.012068433,0.02855087,0.02183099,-0.03236354,0.0011686947,0.008264904,0.053075027,0.05512194,-0.0049558496,-0.024780625,-0.015494106,0.0027760754,-0.09446188,-0.01512755,-0.00077995204,0.008510083,0.013880627,0.051630683,0.05147516,-0.0854129,-0.025972791,0.062422246,0.013771266,-3.1271116e-34,0.11187613,-0.059308555,0.09749823,-0.11660472,-0.03567441,0.13298188,0.06659022,-0.1373374,0.039794657,-0.054096118,0.036368597,-0.016301366,-0.035395935,-0.055045318,0.010924399,0.03569777,-0.051909238,0.049865764,-0.015594678,-0.003828571,-0.01759632,0.15359016,0.06527285,0.011217642,0.019290673,-0.00020627154,-0.04341765,0.040859602,0.0030301362,0.10515693,-0.07161501,-0.01702582,-0.058844127,-0.035923403,-0.0012497043,0.038632583,0.012738253,0.021025067,-0.053279087,0.027674146,0.041384093,0.049547907,-0.010919718,0.12091086,0.046216514,0.074204534,0.0013748389,-0.025355585,-0.04829111,-0.07196347,-0.00094324304,-0.005894024,-0.0046142903,-0.0065544895,0.004807024,0.07887704,-0.028917301,0.017182022,0.043566275,-0.016395876,-0.0149267055,-0.022121314,0.0012666478,-0.015049983,0.017209068,0.045140073,-0.015445369,0.04147395,0.053016435,-0.004307726,0.012908944,0.09841488,0.006866067,0.021436252,0.0143863605,0.036765102,-0.1425117,0.003824076,0.011858512,-0.06083742,-0.086593725,0.08032951,-0.06939421,-0.07170094,-0.00024719659,-0.03423061,0.045343265,0.041804638,0.0022748027,-0.037727926,-0.014808083,-0.0052066376,-0.047205884,0.07073735,-0.0002542284,-3.4088714e-08,0.011686827,-0.013507056,0.023800801,-0.09491587,-0.026050754,0.072287336,0.07050892,-0.0037429174,0.029418213,0.021935686,0.0022733146,0.10751533,0.029863616,0.016096402,0.042094957,0.006552046,-0.041024216,0.02172348,-0.044918474,-0.08113015,0.008195272,-0.04006716,-0.10088187,0.15682206,0.0040737395,-0.067472376,-0.007204758,0.024919054,0.021418616,-0.04165865,0.064947665,-0.022125555,-0.006264721,-0.024007458,-0.08644545,0.04529629,0.006648635,-0.038911503,-0.017786339,0.0063342284,-0.017861314,-0.010883023,-0.009872842,-0.016124899,0.03549394,0.05207932,0.0012871108,-0.054072298,-0.022878155,0.033756234,0.07920727,-0.035446268,-0.045087893,-0.030701999,-0.15165769,-0.071729355,0.0073939,-0.06972311,-0.005012977,-0.0967016,0.036130074,0.0022874947,0.13493626,-0.06977587 +4.3.1.13,"A pyridoxal-phosphate protein. The enzyme cleaves a carbon-oxygen bond, releasing CO2, ammonia, and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and a second ammonia molecule. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. ",384,1.0,-0.053543262,-0.038408794,-0.038664084,-0.037503164,0.045850143,0.026351305,0.064686306,-0.0016730933,0.027573049,0.07888058,0.033101656,-0.02472234,-0.098313704,0.0881183,-0.029356606,0.08015225,-0.08103023,-0.014274748,0.028134786,-0.03580685,0.11213015,0.040714942,-0.036776002,0.038850024,0.02624052,0.09065116,0.069017455,0.0071654404,0.02366937,-0.07853611,-0.071872614,-0.07340437,0.015334521,-0.09069528,0.09405,0.1195409,-0.070613205,-0.0167992,0.019012965,-0.00777831,0.058164347,-0.005669144,-0.052372318,-0.024528313,-0.05352692,0.016529432,0.041963395,0.05117638,0.0065479726,-0.014840201,-0.041976057,0.009823544,-0.03888119,-0.009297149,0.010080171,-0.006670197,-0.036701616,0.02495107,-0.06167817,-0.033997573,0.059591062,0.016701415,-0.005591015,-0.010906667,0.075191,-0.050275017,0.050658334,-0.04599814,-0.025946602,0.0073097707,-0.059238516,-0.07590715,-0.0033661805,-0.0065174922,0.031395808,0.0047491244,-0.04768721,-0.018771008,0.0069769244,0.032434102,0.035364754,0.013138536,0.035348024,0.009824964,0.053124145,0.003711429,0.026792107,-0.020781597,0.044029146,-0.039874647,-0.073090956,0.0043762485,0.062323283,0.031040547,0.014191955,0.022406587,0.02340245,0.019936671,0.030253066,-0.0044656587,0.012328895,0.101159684,-0.07814075,-0.092617884,-0.0629111,0.0014390546,-0.005969818,0.061266262,0.054949716,0.040672626,-0.08511647,0.019724192,0.049130257,0.044109628,0.04157451,0.11728517,0.055762228,0.01839834,-0.00286828,0.014144032,0.037931718,-0.00987881,0.026527379,0.11507004,-0.104305446,0.03780431,-0.14416696,1.2526269e-33,0.035445318,-0.010068089,0.027050847,0.04344334,-0.04501486,-0.0373347,-0.09875497,0.011878456,-0.04421757,-0.04133061,-0.04333072,-0.016541716,0.09657176,0.034796078,-0.02889572,-0.09213384,-0.0438606,0.091998555,0.11482392,0.03756842,-0.002619183,0.10363653,-0.037357632,0.07409933,-0.0010635668,0.06420846,-0.0072379527,0.021384655,0.024505027,-0.03282314,0.069628775,-0.098351896,-0.13459046,-0.026695885,0.01682358,-0.10511537,-0.041838884,-0.012079004,-0.018756185,0.04006878,-0.06766729,-0.021813484,-0.030560412,-0.045012213,0.024182552,-0.10614292,0.004576945,0.05422832,-0.021634813,-0.009635544,0.0313118,-0.025282389,0.052751,-0.034459293,-0.12079394,-0.028225586,0.02096439,-0.011925869,0.027447738,0.049546894,0.024931083,0.037450496,-0.053729,0.0060842326,-0.0574036,-0.049510293,-0.029109469,-0.08022622,0.033556066,0.10733484,-0.078639865,0.039131965,0.02664533,0.001639892,0.011400386,-0.087269925,-0.09341391,0.0029854628,-0.034323648,0.05776762,-0.0022673584,-0.053051054,0.0021641275,-0.019460434,-0.037547227,-0.06985734,-0.044872515,-0.06931429,-0.0075167906,0.054886974,-0.018487569,-0.058229733,-0.029301696,-0.005424655,0.034253478,-2.5940528e-33,0.1218932,-0.074947275,-0.0015476377,-0.043350466,-0.055618335,0.042422637,0.054906953,0.008917628,-0.031089023,-0.033693235,0.02303271,-0.010542447,0.090425424,0.01658341,0.038894292,-0.00093131507,0.00022858931,0.00033736197,0.047297478,-0.00075633626,0.042340353,0.033120606,0.0010712063,0.020630464,0.037355416,0.07977194,0.0003387752,0.042065054,0.009734468,0.035272244,-0.06012867,0.0036774233,-0.04307681,-0.04213927,-0.0950401,0.062025093,-0.06370189,-0.070798956,-0.064949624,-0.011154567,0.007223736,0.077823676,0.03347741,0.04073859,0.0021842367,0.02396858,-0.030386206,0.022092683,-0.0093886675,0.012938992,0.04839594,0.074867144,-0.022151489,-0.027367314,0.0029015879,0.0077840798,-0.046775147,0.01668613,0.019852871,0.085151434,-0.0055135572,-0.07088486,0.010285588,0.02407426,0.03478342,-0.011274544,-0.012107227,0.019910794,0.035723154,0.055641495,0.07063477,0.029401299,0.033312194,0.044327922,0.0017658515,-0.0074829524,-0.033493046,-0.02496656,0.024424473,-0.07612235,-0.032234304,-0.033577524,0.025699796,-0.0769927,0.006234076,-0.071635135,0.022016982,0.05210402,-0.013848466,0.037118055,0.023252126,-0.068589106,-0.008323816,0.114415936,0.046579015,-4.544488e-08,0.06212771,-0.10083664,0.049453173,-0.008612465,-0.009025413,0.0042536217,0.052853025,-0.027974492,0.0734203,-0.071041174,0.020859092,0.00080284505,0.031633895,0.05222247,0.044235766,0.047122877,-0.010507806,0.046615493,-0.004480574,-0.06939529,-0.060094688,-0.026906757,-0.16169095,0.07787919,0.034414575,-0.036536165,0.009601502,0.049136568,-0.008181165,0.0059974664,-0.008530867,0.038147707,0.062182136,-0.05610429,-0.048634212,0.032465443,-0.077976674,-0.01385193,-0.07024598,-0.030788738,-0.008395453,0.054702897,-0.08782404,-0.016259134,0.033097364,0.064088665,-0.01616764,-0.00082588015,-0.0054239873,-0.016997142,0.057945058,-0.021033222,-0.0080447355,-0.044849157,-0.11251522,0.048555173,-0.014180697,-0.062245924,0.0050131613,-0.056675985,0.023659928,0.01999543,0.17620836,-0.08054519 +4.3.1.14,Hydroxylamine can replace ammonia as a substrate. Crotonoyl-pantetheine can replace crotonoyl-CoA but it is a poorer substrate.,384,1.0,-0.03971097,-0.076137,0.08278113,-0.12877946,-0.019199416,0.024237305,0.038692754,0.010418455,-0.046890207,-0.049977567,-0.0732047,-0.058991857,-0.037005093,0.059966065,-0.026585098,0.036082268,0.02872922,-0.08717944,0.02952623,0.041112404,0.0251048,0.0038910715,-0.04786923,0.046964206,0.04887363,0.097099684,-0.016157862,0.05896781,0.029522613,-0.0007127904,-0.01366738,0.06039884,-0.024694392,-0.023922462,0.0018968167,0.030287422,-0.037139297,0.0028097809,0.003170955,0.023973191,0.01640801,-0.017315494,-0.054097205,-0.06443328,-0.020406028,-0.0069556846,0.05244286,-0.075021446,-0.041788515,0.0121182,-0.042494193,-0.04349017,0.013844562,0.032574356,0.07876418,0.07172249,-0.038354326,0.0884487,-0.047028184,0.025781274,-0.03381369,0.01484706,-0.043248657,-0.034670606,0.046019018,-0.014649075,-0.063850075,0.0022152849,0.0575916,0.025718866,-0.031865567,-0.076211445,0.041595522,0.042594735,-0.013885328,-0.005067073,0.0077549056,-0.050380766,0.019627236,-0.008845499,-0.06943472,0.08392547,0.035307873,0.06377234,0.10528948,0.03640264,-0.011388108,-0.03364749,0.015381849,-0.080975555,-0.048284795,0.030876182,0.0697162,0.020011716,-0.03679638,0.038253907,0.046444036,-0.062305633,0.07056319,0.01891942,0.046764288,0.06284628,-0.11288106,-0.034939297,-0.10578768,-0.0017270264,0.033086345,0.12789555,-0.026263377,-0.033919405,-0.021305272,0.017824668,0.036446348,-0.008318475,-0.052993026,-0.02790336,-0.0023338275,-0.03854222,0.0120791895,0.02936397,-0.011592312,-0.049754523,-0.019656947,0.057435527,-0.02502475,0.050602008,-0.027980536,2.441189e-33,-0.0013082926,0.034424562,0.0044826753,-0.051756334,-0.061018903,0.023413511,-0.019055715,0.047876354,0.061316926,-0.17139225,-0.019534715,0.0144531615,-0.04927956,-0.0065738503,-0.017653074,-0.03949016,-0.07010169,0.031711224,0.06548797,0.014008203,-0.019095251,0.02690537,-0.06622051,0.019236082,-0.068987116,-0.08933855,-0.0026792285,0.04507159,-0.027860936,0.023966001,0.1102615,0.039963953,-0.035827477,0.019406427,-0.09091829,0.005310679,-0.118008055,-0.0010517638,-0.07682398,0.07609317,-0.0237131,0.059309147,0.022600591,0.01013192,0.053069588,-0.030254142,-0.059312478,0.040319614,-0.0052980776,-0.043745056,0.009246919,0.015042556,0.0006911615,-0.027542233,-0.02382754,0.016563956,0.045655064,-0.027282458,0.060273793,0.050064042,-0.06009255,0.01374986,-0.03189511,0.034946054,0.029280009,0.013019154,0.03417839,-0.028480932,-0.07561033,0.0038381347,-0.018298322,0.042839345,0.03822717,0.1063648,0.029865174,-0.13981399,-0.01723618,0.012360487,0.02171135,-0.009805953,0.11371916,-0.010224484,0.050622817,-0.047548734,-0.050222736,-0.09892756,0.081115656,-0.028933536,0.012022467,0.08282648,0.08408929,-0.1367724,0.009968274,-0.02937227,-0.059043188,-1.5671942e-33,0.03133706,-0.06237361,0.0016802584,-0.0025582614,-0.06291073,0.04907236,0.094969735,-0.054402534,0.02927259,0.03354316,0.12576428,0.03325127,0.009023834,0.040026195,-0.059105497,0.033714283,-0.036426034,-0.040694773,0.021288518,0.020857409,0.07517401,0.03751877,-0.023100937,0.07898858,0.025304534,0.017917842,-0.004814813,0.029724218,0.07137942,-0.016792582,-0.010572452,-0.05669885,0.026736712,-0.043690093,0.02085447,0.057086434,0.030187536,-0.017977485,-0.10894627,-0.02659336,0.019348873,-0.0076315426,0.103276506,0.030812865,-0.05613717,0.083618514,-0.12643638,-0.054328945,-0.003051963,0.032357376,0.0333108,0.017078098,-0.020215254,-0.031004362,0.033826753,-0.005507427,0.0021218474,-0.031447247,0.010792013,-0.029335462,-0.01806054,-0.0134541085,0.023694271,-0.0021304637,0.09083945,0.024567543,-0.04414409,0.066355705,-0.0034878212,0.021369606,0.049471114,-0.031432632,0.13384894,-0.027992891,-0.009323079,-0.08252389,0.0026382827,0.030670818,-0.07778582,-0.015977118,0.09137141,-0.012901695,0.034587093,-0.03945689,-0.005941871,0.04408884,0.024441909,0.06706159,-0.06667277,0.03922138,0.04782827,0.008320712,0.01762379,0.002116663,0.14502603,-2.7523729e-08,0.012379202,-0.13951029,-0.0013380658,0.0030328708,-0.021365367,-0.011638013,-0.0039889296,0.002931183,0.042968184,-0.052850854,-0.04089084,0.018534435,0.08485004,0.02358997,-0.037973832,0.004927564,-0.04361789,-0.06762309,-0.009187675,-0.02539517,-0.13590366,0.040402893,-0.043401293,0.043368928,0.027776664,0.013926876,0.011168044,0.07447527,-0.00020135171,-0.06425112,-0.049416184,0.02472418,0.051770262,0.049042743,-0.052511603,-0.006138636,-0.018569436,-0.002741166,-0.08411646,-0.017676292,0.0371107,-0.07151743,-0.018945187,-0.016384138,0.14603877,-0.039145567,-0.0065082237,-0.005840421,-0.0075946394,-0.024720144,0.07462451,0.023697237,0.08370681,-0.06602409,-0.037800614,-0.02544646,-0.0056235394,-0.074919924,-0.013684601,-0.007235889,-0.0014081495,0.029100807,0.13449802,0.009643331 +4.3.1.15,A pyridoxal phosphate enzyme. Active towards both D- and L-diaminopropanoate. D- and L-serine are poor substrates.,384,0.99999994,0.008468307,-0.097369894,-0.028723136,-0.11912737,0.031912316,0.022518417,-0.033739354,-0.01444991,0.010189454,0.08032428,-0.023542432,0.04033638,-0.08013406,0.059544213,0.014225289,0.070218,-0.034204476,0.05748341,0.006529576,0.03291256,0.11981937,-0.0039020814,0.040774744,-0.016331267,0.051301297,0.07101936,0.043027844,0.05409776,-0.0318678,-0.046645284,-0.10702147,-0.034331743,-0.0034824347,-0.081380695,0.0851142,0.050716244,-0.08279015,0.046773363,-0.046149887,0.012884885,0.07744059,-0.043945998,-0.021416368,-0.013443817,-0.07547729,-0.010684368,-0.0056318534,0.07201477,0.012383147,-0.03652078,-0.06251249,-0.03319333,-0.026293222,-0.04027806,-0.11221538,0.0415381,0.014436669,0.07193969,-0.028310575,0.012086055,-0.0010286856,0.044763617,0.013565909,-0.029244896,0.05737751,-0.07486953,0.015777724,-0.067270145,0.0010252731,-0.01536601,-0.04826379,-0.054949418,0.07853305,0.014721045,0.02517564,0.049877696,0.0025124613,0.0030827643,0.007416227,-0.0288737,0.11137257,0.026102629,-0.011351711,0.077598736,0.029341556,0.05220151,-0.027779685,0.032655105,0.025787411,-0.03991223,0.016472347,-0.009318743,-0.013157309,0.005469599,-0.0325512,0.037204906,-0.004735431,0.073694706,-0.03626239,-0.0375554,0.003931198,0.032318767,-0.0746023,-0.05890056,-0.06451694,-0.0075595872,-0.047488846,0.046420198,0.00015743975,-0.03243129,-0.006879381,0.059138738,0.015420607,0.061593387,-0.05467987,0.011535833,0.018544216,-0.050590873,-0.051249057,0.025490938,-0.00799117,-0.046771757,0.057470873,0.11392728,-0.025652733,0.01473633,-0.038821943,-5.377115e-34,0.10469047,0.066249944,0.04215202,-0.06605205,-0.06029786,-0.038189534,-0.09986354,-0.013195763,-0.026665987,0.0050717536,-0.05291769,-0.055285264,0.05196094,0.011653204,-0.07782894,0.0021050419,0.011096924,0.089935005,0.047521945,-0.050619047,0.10518904,0.10730827,-0.009158016,0.09894386,-0.016208135,0.04995973,-0.022508444,0.034424793,0.06699798,-0.010186768,0.0127715245,-0.16223492,-0.0023569295,-0.03017186,0.03247129,-0.034580637,-0.072491124,-0.05919045,0.0006181547,0.008451262,-0.08925238,-0.031632576,-0.008111892,0.017181879,-0.012990979,-0.06529711,-0.004860614,0.078455016,-0.009461212,0.027181776,0.035348836,-0.07128178,0.059458863,0.011772298,-0.10991863,-0.016336577,-0.040273324,-0.06656524,0.062316228,0.024075748,0.05936169,-0.04554759,-0.04010597,0.034315273,0.03299539,-0.040285584,0.0245152,-0.0020214831,0.02804105,0.06596328,0.0015840643,-0.08741123,0.053227693,0.047013026,0.03238654,-0.06583528,0.000800512,0.0067519206,0.001132604,0.029152147,0.08788829,-0.043954477,-0.09654172,-0.033283383,-0.023399677,0.010263312,-0.042187482,-0.0411107,0.032299425,0.03432756,-0.04158968,-0.07863575,-0.01931759,0.007265199,0.040362127,-1.1842486e-33,0.048971344,-0.058572043,0.05386977,0.0009778255,-0.06623361,0.01574494,0.038938887,0.012980845,0.016257912,-0.03791877,0.0039190813,-0.04329171,0.004330482,-0.020717695,-0.04404973,0.0141473105,-0.034784313,0.03949559,0.034940038,0.049944673,-0.014211678,0.035718326,-0.032192335,0.0928584,0.07937948,0.011545337,-0.03695252,0.06086559,-0.014631545,0.06459906,0.010491011,0.0598644,-0.015241921,-0.0763756,-0.039693195,0.031945013,-0.074881054,-0.023554001,-0.013266445,0.04936569,-0.035702273,0.042229738,0.069299445,-0.019308846,0.0023799695,0.01382176,-0.08694342,-0.013291221,0.037050314,-0.057862878,-0.03829628,0.06577843,-0.017465,-0.031718835,0.02653894,0.07353614,-0.008414275,0.044690438,-0.028326679,0.035187174,-0.0043113814,-0.121523455,-0.019654434,0.050645657,0.023807619,0.12497605,0.037679836,0.0726144,0.011020958,0.05233376,0.015925325,0.05854862,0.05246496,0.08380642,-0.048571587,-0.045736775,-0.041905668,0.020533103,0.029472994,-0.014447735,0.0018954137,0.0014628005,-0.041911025,-0.06822937,-0.05426665,-0.002134784,0.055770494,0.107401155,-0.05269339,0.014112453,0.042258672,-0.06297658,0.0062637758,0.04924385,0.07704296,-3.0674265e-08,0.106695384,-0.03059488,0.08860014,-0.06363505,-0.027698798,-0.03283944,0.048038468,0.004656197,0.058097817,-0.07754578,-0.007953001,0.0005218264,0.0023234326,-0.035896245,0.07687211,0.031929575,-0.002037177,0.051158816,-0.033828877,0.0018581353,-0.010631429,-0.019926269,-0.13780974,-0.004971893,0.09268503,-0.0034512442,-0.0044415845,0.07677358,-0.025213137,0.016404426,0.047492586,-0.035826176,0.025927583,-0.10215803,-0.024170948,0.039546322,-0.07031086,-0.04548697,-0.0735988,-0.056996066,-0.020046743,-0.019520056,0.017593184,0.0017536515,-0.022340557,0.0592922,0.013283631,-0.0063023414,-0.02665271,0.0011599261,0.047077153,-0.036628768,-0.053821936,-0.11479763,-0.13346346,0.07459866,0.03366217,-0.049352877,-0.03668073,-0.11225135,0.0041679936,-0.03099949,0.099653885,-0.087435186 +4.3.1.16,"A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Pseudomonas sp. T62, is highly specific, and does not accept any other stereoisomer of 3-hydroxyaspartate. Different from EC 4.3.1.20, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.27, threo-3-hydroxy-D-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Mg2+, or Ca2+.",384,1.0,-0.043666895,-0.10966664,-0.063073,-0.09832282,0.02830253,0.06700231,-0.07091043,0.026333299,0.014869239,0.017970607,0.050087992,-0.06249886,-0.09903221,0.0674554,-0.0014733885,0.008003043,-0.03918777,-0.0026181086,0.030717991,0.01290731,0.10218011,0.068906315,-0.04504816,0.03855533,0.05794237,0.07799985,0.09124531,0.0047685453,-0.004807027,-0.04876014,-0.072799936,-0.043347828,0.056770958,-0.10040722,0.101855,0.09179217,-0.06307164,-0.046942737,0.054503143,-0.016909935,0.07360714,-0.01801448,0.016125709,-0.06788164,-0.069039464,0.022880431,0.07581856,0.025044562,0.08942712,-0.07742478,-0.07182602,-0.041652765,-0.0062338524,0.032577936,-0.037307646,0.027568575,0.052338406,-0.0010570533,-0.062058337,-0.0015882388,-0.027314177,-0.01242661,0.037440952,0.0020862354,0.066395044,-0.02637739,0.0068645515,-0.060777955,-0.017248733,-0.001270856,-0.061653335,-0.048921376,0.11077713,0.046803623,0.002542859,0.02912666,-0.0139128445,-0.043731865,-0.017832598,-0.02359318,-0.00755212,-0.030223703,0.030436995,0.08200616,0.04163222,-0.04801713,-0.037128896,0.0020937005,0.042195335,-0.009387884,0.01374795,0.008491151,0.027867725,-0.041195262,0.006209221,0.0718271,0.007793947,0.016298411,0.065847024,-0.057912465,0.03523775,0.047718372,-0.060001962,-0.078506164,-0.009398046,0.03949076,-0.041912228,0.068745464,0.047132056,0.016278502,-0.030244866,0.0040084724,0.024479164,-0.022101147,-0.053808756,0.010983759,0.068171374,-0.07112086,-0.058161628,0.020090312,0.026864821,-0.05784917,0.058562003,0.10197191,0.0020566452,-0.014117935,-0.114742525,3.1671286e-33,0.06558622,0.051588293,0.015955122,-0.04080694,0.005164849,0.032695487,-0.06368731,-0.037752744,-0.037750416,-0.055120885,-0.055342525,-0.014388182,0.030026067,-0.0019174338,-0.06994238,-0.021191094,-0.10289784,0.064337656,0.059733517,0.014407575,0.058099795,0.039059296,-0.042933106,0.04534063,-0.012657099,0.046364907,0.05423041,0.00070421834,0.0011366442,-0.01342561,0.030697877,-0.10957933,-0.12743546,-0.032351866,0.04301706,-0.06703977,-0.083884686,-0.04924287,-0.03653649,0.04065487,0.017994042,0.037543006,-0.025021274,-0.0014207681,0.05136487,-0.081095174,0.011579685,0.07433478,-0.0075411,0.08167886,0.033093646,-0.043220002,0.055116743,-0.026459243,-0.08304064,-0.06874732,-0.015657265,0.06217724,0.056052532,0.025977869,0.028658347,0.061266,-0.018204166,-0.008846152,-0.05220017,-0.0035785823,0.021576632,-0.0352483,0.0565686,0.049241763,-0.037556596,-0.0039306576,0.016435983,0.09532184,0.002486022,-0.11401031,-0.061566573,0.032160234,0.010877624,0.0012555158,-0.04974909,-0.017167332,0.022830123,0.020346208,-0.116162725,0.006211035,0.03195189,-0.037958384,-0.029136948,-0.0023732097,0.08001537,-0.114999086,-0.062140897,0.09632316,-0.0051893657,-3.4817492e-33,0.055593397,-0.078183115,0.10532071,-0.066988975,-0.050602436,-0.00211578,0.06474612,0.07782959,0.032099366,-0.027707076,0.1228705,0.037408073,0.020965515,-0.029057728,0.018720098,0.042388596,0.016106835,-0.0051502674,0.029826734,0.007868437,0.054923434,0.019274978,-0.011461951,0.09611218,0.057988476,0.06606191,0.0041830363,0.0374294,-0.002805669,0.071689904,0.0073490804,0.05323828,-0.058853712,-0.06764007,-0.05194622,-0.011336537,-0.089637704,0.00015050039,-0.0004136965,0.006014239,0.07461456,0.065241046,0.028336752,0.04782606,-0.04678457,0.05410878,-0.046206404,-0.00019545964,0.030295184,-0.02271078,-0.020331047,0.015201849,0.032611217,-0.0011536867,0.0140406275,-0.025831264,-0.035550814,0.033407737,-0.03143726,0.0045498456,-0.0267858,-0.09770912,0.045282558,-0.0104352925,0.021558048,0.0665268,0.019906096,0.020824093,0.034711983,0.059562866,0.074212424,0.029947964,0.010581792,0.05211456,-0.042453814,-0.02158227,-0.025243035,0.02293291,0.016879356,0.008515368,0.05312365,-0.0034708453,-0.009835298,-0.07357762,0.062345117,-0.02945819,0.056630246,0.098324195,-0.06789131,0.02683943,0.031378042,-0.038588975,-0.0028970568,0.029110458,0.08591012,-5.273745e-08,0.07112423,-0.09372987,0.04988811,-0.048125286,-0.013744828,0.017082116,-0.023478111,-0.00013099586,0.048035435,-0.021662172,0.01424764,-0.012096822,-0.024471546,-0.013918558,0.065176375,0.013125917,-0.08319148,0.036724493,-0.021247962,-0.027313814,-0.06740125,-0.013545486,-0.15702768,-0.010856084,0.057027146,0.059037056,0.009675514,-0.024820697,0.005807458,-0.02370765,0.009882403,0.005300388,0.0026176788,-0.014231852,-0.0830506,0.026415344,-0.0647421,-0.021151667,-0.08623929,-0.030477371,-0.0039258576,-0.017679432,-0.058024578,-0.023374869,0.036283884,0.061713792,-0.04020945,0.031265795,-0.03572241,-0.05924941,0.11603874,-0.072113425,-0.0053304504,-0.06416798,-0.13693568,0.020338716,-0.004344254,-0.057543337,-0.048075225,-0.03510482,0.04264284,-0.029755183,0.1313349,-0.015889868 +4.3.1.17,"Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead [6]. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.13, L-serine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. This reaction is also carried out by EC 4.3.1.19, threonine ammonia-lyase, from a number of sources. ",384,1.0,-0.043719504,-0.044572588,-0.051310603,-0.013151105,0.0828,0.023332799,-0.00063715444,0.026810544,-0.008160183,0.055684395,-0.0029585375,-0.048028734,-0.057910394,0.061191007,-0.0364054,0.04490511,-0.07538159,-0.026403615,-0.0032696638,-0.05461,0.061325483,-0.017663585,-0.047522575,0.010074312,0.028073745,0.06415692,0.08552087,-0.0324876,-0.08237192,-0.08454317,-0.06874162,-0.099911325,0.038505465,-0.10231128,0.032658737,0.046184115,-0.09578655,-0.061872836,0.036298152,-0.057535544,0.0016391202,-0.024591291,-0.025218733,-0.08816956,-0.024341779,-0.03828636,0.026800465,0.036845334,0.0054801838,-0.013861916,-0.05455353,-0.004821755,0.012362085,0.027827436,0.004738366,-0.07275982,-0.042657442,0.041301206,-0.0016007301,0.018410876,0.07374147,0.03753157,-0.023210328,-0.05917223,0.0112199485,0.0041917446,0.04832524,-0.043318875,0.019110797,-0.027457159,-0.05716262,-0.07455261,-0.019833917,-0.00555186,0.0040619066,0.0026568105,0.032436408,-0.026503153,0.040934227,0.043923702,0.011781707,0.012565654,0.076259375,0.013232113,0.030613832,0.020312903,-0.0012179727,0.030120555,0.093855016,-0.0017021165,-0.0072390824,0.01762149,0.0013212172,-0.006999098,0.028905237,0.050436232,-0.034830824,0.13037843,0.045476153,-0.031218044,0.034385536,0.09707556,-0.09465973,-0.109026454,0.016964376,0.025773784,0.08542813,0.0827266,0.06637375,0.001083682,-0.049221374,-0.08298445,0.023011701,0.046288554,-0.051516682,0.11921566,0.08157212,-0.03017259,-0.06811327,-0.025717476,0.08783498,0.016854169,0.11138345,0.10477357,-0.036529213,0.044734128,-0.15664107,1.78247e-33,0.029805854,0.040806133,0.039945714,-0.040132515,0.011424782,-0.047687657,-0.10713967,0.083969094,-0.02188697,-0.053482797,-0.096110925,-0.05063642,0.06839705,-0.031650186,-0.027761763,-0.11287622,0.012698482,0.05215807,0.053358342,0.048551295,0.022788292,0.0569138,-0.047624268,0.032085955,-0.029663825,0.05574137,0.023442931,0.03186055,0.03902376,-0.02430472,0.057439785,-0.13130355,-0.06429403,-0.011373842,0.028590122,-0.08134526,-0.03155149,0.03392771,0.0060039023,0.068417184,-0.00539209,0.041134372,0.01918931,-0.07970398,0.028906552,-0.06806517,-0.05932005,0.07477995,0.04849478,0.005443974,0.016791709,-0.009915876,0.08543625,-0.010107622,-0.060832802,-0.0013022867,0.0039657066,0.015177279,0.08082615,0.077659264,0.016227338,0.040416654,-0.031234926,-0.0024422614,-0.04223227,-0.015265972,-0.011797462,0.01276579,0.020569189,0.068827994,-0.05078428,-0.012111091,0.071495265,0.03844795,0.053955726,-0.07471394,-0.093131915,-0.017726682,-0.025110789,0.030929293,-0.010926042,0.0151552195,-0.0035371406,0.026395177,-0.017535303,-0.0065038432,-0.067331724,-0.014449238,-0.006922601,0.09120537,-0.019427545,-0.07309018,-0.07156577,-0.034474477,0.04317262,-2.9356407e-33,0.10984312,-0.040283136,-0.030134957,-0.09360401,-0.097690634,0.06278663,0.07658137,-0.0126474425,0.037548043,-0.013950655,0.038490493,-0.022466147,0.08351148,-0.025794368,-0.003964705,0.005209428,-0.021538563,0.057075255,0.035140786,-0.013885683,0.05209274,0.019850098,-0.008898492,0.016951336,0.072829574,0.03920022,0.073493354,0.055374533,0.06263691,0.07193275,-0.07260126,0.006907468,-0.022752825,-0.05498576,-0.06494717,0.07381829,-0.018317029,-0.071319185,-0.020447297,0.02595787,-0.019500576,0.01804957,0.02716682,0.0635325,-0.013062313,0.045733277,-0.052192315,0.040575836,-0.029849354,-0.014653828,0.034960393,0.023798585,-0.024793025,0.0043825847,-0.025193281,-0.008607927,0.0009269098,0.052324954,-0.06185875,0.04398291,-0.0012850886,-0.056218345,0.04850586,-0.07060302,-0.0010774651,0.018555196,-0.06948574,0.058517776,0.0030486344,-0.016175807,0.029019915,-0.064971015,0.0013276804,0.012927096,-0.0059098443,-0.009715654,0.0014884676,-0.0047588055,0.027193202,-0.07097538,0.019546872,-0.009413455,0.0092494525,-0.084551476,0.006902466,-0.06577844,0.049957506,0.049016237,-0.044355486,0.052993752,-0.0012156807,-0.0606429,-0.015543713,0.11013997,0.016844004,-4.78342e-08,0.045225624,-0.114654325,0.053227372,0.006454726,-0.0027494843,0.040146623,0.0115964245,-0.008712866,0.031043082,-0.07743317,-0.0061692162,0.024722666,0.0036670465,0.026036095,0.031942833,0.01432344,0.006242926,0.045162972,-0.032435115,-0.0010637464,-0.07292822,-0.018555366,-0.18895894,0.0156085575,0.02915968,-0.027468504,0.0032285077,-0.022835258,-0.024615457,-0.01785144,-0.034047343,0.021774229,0.0056899013,-0.047106102,-0.027234053,-0.00037326122,-0.07624406,-0.027138501,-0.063626125,-0.044508476,-0.013750069,0.01487514,-0.07576745,0.022998653,0.022928787,0.04283667,-0.04410362,0.02152764,-0.008676052,-0.0024761031,0.04702566,-0.025996216,0.055769105,-0.057973627,-0.0613418,0.09980752,0.025631137,-0.08836497,0.03652393,0.023270184,0.077260464,0.01226881,0.1817987,-0.054106917 +4.3.1.18,"A pyridoxal-phosphate protein. The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme's original classification as EC 4.2.1.14, D-serine dehydratase) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also acts, slowly, on D-threonine.",384,1.0,-0.061386246,-0.049800146,-0.027542407,-0.03880678,0.06482526,0.008708112,0.035781685,0.02604898,0.03786783,0.09428969,-0.004117676,-0.011840035,-0.08477621,0.07635581,-0.047101527,0.056255687,-0.07103622,-0.017003622,0.010217851,-0.01793428,0.11292252,0.027650155,-0.020959778,0.015759613,0.04642467,0.086811215,0.08005601,0.029081691,-0.008936464,-0.07692561,-0.061558526,-0.07292749,0.017047096,-0.09211348,0.08959357,0.11698602,-0.07110834,-0.0016105041,0.024103394,-0.030315002,0.076218955,-0.013492635,-0.057273686,-0.008213806,-0.043550517,0.018222034,0.027563358,0.06997609,-0.009007641,-0.021433635,-0.04044247,-0.0052680024,-0.013372685,0.025595514,-0.012454333,-0.018034646,-0.0076454906,0.033100896,-0.06749793,-0.041456115,0.05734904,0.005524393,-0.0046508657,-0.038733225,0.06885097,-0.040615212,0.036188006,-0.04775809,0.0124603035,-0.019485207,-0.07408682,-0.065055974,0.02954933,0.02332692,0.029229818,-0.031195913,-0.028908676,-0.03148006,0.010943912,0.013011129,0.048945833,0.011854452,0.05653557,0.014944287,0.048703067,0.027441606,0.02988192,-0.03130943,0.06537837,-0.042266734,-0.07378299,-0.0023185408,0.016725546,0.012357497,0.008179094,0.031854905,0.01811581,0.040207777,0.021255562,-0.029781386,0.020466318,0.10246508,-0.12116624,-0.07304846,-0.025670027,-0.00992962,0.029096818,0.06032878,0.042772345,0.0036354274,-0.07025731,-0.031069702,0.048980504,0.08862598,-0.017152058,0.09185067,0.046736326,0.004132259,-0.040175483,-0.01782611,0.045180716,-0.0033394285,0.06836659,0.10644555,-0.08443411,0.061220683,-0.13074476,7.3796015e-34,0.041226156,-0.02079395,0.028091094,0.02541072,-0.028080495,-0.055581737,-0.11890979,0.04366058,-0.015121383,-0.041502725,-0.0803994,-0.053914472,0.08417144,0.033802878,-0.049856797,-0.110311486,-0.03259607,0.077123396,0.08481263,0.009885166,0.038674902,0.08749157,-0.038981352,0.06842682,-0.0013880129,0.044187542,-0.017558366,0.063294336,0.051341545,-0.026267003,0.041487936,-0.1185275,-0.08679164,-0.014793073,0.010115717,-0.0829236,-0.06960922,-0.0069387513,-0.0027067743,0.049950317,-0.07138418,-0.013494966,-0.023631645,-0.056563977,0.00805498,-0.080228925,0.0013320107,0.0728275,0.0017623856,6.7813235e-05,0.04812779,-0.04954246,0.07888667,-0.050312206,-0.11462643,-0.027268168,0.022035312,-0.03621237,0.036998402,0.07933745,0.028343942,0.046226133,-0.05346877,0.001747218,-0.05166019,-0.02949378,-0.029789379,-0.05856036,0.032953665,0.07231182,-0.064859964,0.035148922,0.06027177,-0.002787841,0.022963097,-0.061247833,-0.09159916,0.0022468842,-0.04330597,0.037013188,0.0038966448,-0.04729128,-0.020648845,0.008998366,-0.03167476,-0.039769527,-0.034045104,-0.07157939,0.0006103712,0.06218304,-0.038523905,-0.0707777,-0.04247264,-0.026817562,0.07125567,-2.3487813e-33,0.103705235,-0.04432995,-0.015709708,-0.009899527,-0.02384216,0.062016197,0.03919893,0.043975838,0.005029404,-0.05326171,0.031694412,-0.031208882,0.042885765,0.008802797,0.017688975,0.007761266,-0.02378954,-0.013869036,0.040519904,0.0031598783,0.034333482,0.03237996,-0.015212674,0.032066442,0.056885708,0.067622714,0.038959954,0.028196363,0.0060762074,0.04866327,-0.059395477,0.02502859,-0.028332448,-0.0243414,-0.07410216,0.10100626,-0.065643795,-0.081755124,-0.06560844,0.011328268,0.0024394528,0.056763876,0.06715169,0.058133923,0.0069927373,0.029292189,-0.03696623,0.025537387,-0.017308546,0.013081546,0.05440354,0.047077645,0.009088045,-0.00013405284,0.022300389,0.016092256,-0.023702431,0.03438449,-0.014472328,0.08080508,0.0061357943,-0.08157218,0.016611753,0.021202456,0.017271647,-0.022793617,-0.044437166,0.05650631,0.04736256,0.042579338,0.07800461,-0.015297438,0.0076009016,0.031037703,-0.032833878,-0.02509691,-0.036342543,-0.01944332,0.0336989,-0.080636024,-0.0316298,-0.007374671,-0.0047797593,-0.07229461,-0.023003822,-0.06589664,0.037426613,0.046743274,-0.022107553,0.0520535,0.020327153,-0.0725207,-0.020591807,0.13202232,0.057289504,-4.778234e-08,0.08364422,-0.10620333,0.060330614,0.010598526,0.0067573646,-0.007582405,0.06535389,0.008275787,0.07734598,-0.0727307,0.008194507,0.009050335,0.025951764,0.005951972,0.04034624,0.04195135,-0.00888101,0.052857675,-0.02797572,-0.051623546,-0.0702203,-0.04619432,-0.18775335,0.044680413,0.035351165,-0.047368865,0.021728663,0.02758158,-0.012470459,-0.016443655,0.01080217,0.03777507,0.03458441,-0.06076825,-0.05410594,0.027803645,-0.09203486,-0.027445044,-0.055398203,-0.027468275,-0.01788697,0.044417426,-0.075314075,-0.0030836293,0.029914584,0.06445702,-0.03493885,-0.017760416,-0.0111482125,-0.020347053,0.03602586,-0.011851852,0.01735293,-0.051215485,-0.12194186,0.09534724,-0.033726975,-0.07282274,0.0088404715,-0.03804354,0.034921195,0.03321431,0.17580862,-0.05366483 +4.3.1.19,"Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.16, threonine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond [3,5]. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase [5]. The enzymes from a number of sources also act on L-serine, cf. EC 4.3.1.17, L-serine ammonia-lyase.",384,1.0,-0.035124503,-0.07076241,-0.053364687,-0.019407514,0.09818949,0.03733054,-0.015441852,0.008200548,0.017163575,0.05155497,-0.019782191,-0.03574209,-0.06388389,0.058835883,-0.03389518,0.04611943,-0.08367809,-0.03959804,-0.0015423036,-0.042043578,0.10032579,-0.030496925,-0.04079769,0.010705073,0.021408865,0.062379856,0.07241478,-0.034088146,-0.08275265,-0.0775521,-0.06669301,-0.08036772,0.02467907,-0.102236256,0.05233274,0.045801267,-0.096995935,-0.045943175,0.031517804,-0.052218188,-0.0024590795,-0.03176793,-0.046451144,-0.08506082,-0.04164566,-0.05023512,0.02417358,0.022864351,-0.020665798,-0.014062447,-0.07064231,-0.0056052385,0.010285102,0.020146033,-0.0058933273,-0.063034974,-0.04102208,0.031630993,-0.0069932216,0.008524787,0.056942146,0.029690295,-0.013395198,-0.062401854,0.036676742,-0.001837431,0.03026738,-0.050438736,0.018831525,-0.048431396,-0.07155396,-0.07530259,-0.0069746105,0.0014215871,0.018275157,0.012934237,0.01989577,-0.0023618801,0.033351142,0.031164713,0.011044276,0.022114912,0.057969134,0.028802373,0.05565588,0.017952178,-0.009589409,0.037465606,0.11477141,-0.008237599,-0.012772062,0.0076069403,-0.014254961,0.014878146,0.04190377,0.048253585,-0.021826357,0.11038852,0.037821885,-0.037043564,0.022611953,0.09495915,-0.095340304,-0.09675189,0.009602675,0.027318995,0.07661482,0.08990774,0.047148038,-0.024083689,-0.06336826,-0.06861209,0.02675152,0.051073242,-0.04497399,0.102881,0.08304857,-0.020809608,-0.06698988,-0.020698916,0.08860944,0.03165546,0.103897296,0.11211799,-0.025706032,0.050437495,-0.15275902,1.78105e-33,0.045712586,0.031502347,0.05354181,-0.04778598,0.014886378,-0.050482724,-0.10224733,0.07382168,-0.007480881,-0.049644772,-0.09797018,-0.04843624,0.07484522,-0.048395194,-0.032923035,-0.09729889,0.016838482,0.0384565,0.054708205,0.044587895,0.04093713,0.060298033,-0.040074278,0.034619175,-0.041798618,0.049861096,0.02032455,0.030980505,0.030422436,-0.020845754,0.05098181,-0.14823699,-0.050795563,-0.01464274,0.041100588,-0.06402051,-0.05165427,0.03358771,-0.008039529,0.06334936,-0.012566483,0.035661478,0.014264556,-0.07001067,0.022593284,-0.061756194,-0.06283008,0.088076904,0.039220564,0.016471842,0.039208494,-0.032245398,0.08993059,-0.021025036,-0.08190891,0.0042463215,-0.012492663,0.016604196,0.06544056,0.08936441,0.0137099875,0.022643672,-0.031235076,-0.0056265485,-0.025102964,-0.013538878,-0.013124442,0.004901961,0.025012776,0.074762836,-0.06427198,0.0051403088,0.07744393,0.0541527,0.06449481,-0.06933075,-0.1015089,-0.01711906,-0.027928812,0.0381131,-0.015057704,-0.002066761,-0.0072245062,0.03249379,-0.031444196,-0.011815785,-0.06415181,-0.040860653,-0.00934612,0.073953524,-0.02361768,-0.08065303,-0.056737173,-0.02855616,0.049421314,-3.2021135e-33,0.11409609,-0.049118176,-0.008001748,-0.09939722,-0.08816767,0.06239771,0.07049219,-0.028634949,0.015694287,-0.0045988713,0.031236475,-0.022159314,0.07372482,-0.0154555645,-0.015213144,0.010997687,-0.021149058,0.044105098,0.058851726,-0.0010253077,0.041089237,0.03154795,-0.006126305,0.025476217,0.09255546,0.05352471,0.05873505,0.068341754,0.055959895,0.056301028,-0.048250835,0.02495203,-0.0053106393,-0.07062818,-0.051390685,0.085251264,-0.047638867,-0.061320767,-0.0023409615,0.03577346,-0.023127932,0.017926171,0.045384277,0.06370091,0.0010776637,0.03060575,-0.057040863,0.016260795,-0.016975667,-0.010965071,0.019695267,0.034239113,-0.02389684,-0.01094074,0.0028113509,0.01719671,-0.001056429,0.040077083,-0.058598176,0.04760649,0.009552244,-0.04840561,0.032972313,-0.042313803,0.0042012935,0.010580208,-0.05638178,0.05356178,0.021986147,-0.010595355,0.04582972,-0.052337304,0.008608931,0.02723668,-0.026031109,-0.018595291,-0.0024337012,0.0046779118,0.019185001,-0.076748095,0.019339839,-0.01371258,0.0033182562,-0.098333254,-0.009505789,-0.06085692,0.06373505,0.055511132,-0.018970009,0.047576874,0.0053537735,-0.059272043,-0.020800885,0.10735394,0.036011286,-4.86e-08,0.05656472,-0.11049777,0.045940835,0.021915097,-0.010358615,0.035619657,0.012818921,-0.02510623,0.040719334,-0.07664893,-0.015027254,0.016307563,0.015357012,0.0015965744,0.039868042,0.021394268,0.005429992,0.026792413,-0.036828384,-0.007879469,-0.06771164,-0.02689746,-0.19864224,0.029125616,0.040296957,-0.046483587,-0.0048758453,-0.022968708,-0.021655807,-0.021281188,-0.015710188,0.020528873,0.036146693,-0.05199938,-0.027264446,0.010127235,-0.08262206,-0.042014193,-0.055018112,-0.03144663,-0.02329412,0.019482188,-0.060937908,0.004260113,0.037452705,0.058369968,-0.05208887,0.0028735746,-0.007644433,0.0013224756,0.052309874,-0.02488315,0.043639287,-0.050443914,-0.061589077,0.11875049,0.008754127,-0.071189195,0.03976366,-0.014524454,0.057035156,0.009500057,0.17905688,-0.058047306 +4.3.1.20,"A pyridoxal-phosphate protein. The enzyme, which was characterized from the bacterium Paracoccus denitrificans NCIMB 8944, is highly specific for the L-isomer of erythro-3-hydroxyaspartate. Different from EC 4.3.1.16, threo-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.27, threo-3-hydroxy-D-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Mg2+, and Ca2+.",384,0.99999994,-0.07097233,-0.13834025,-0.097688235,-0.095621414,0.061287075,0.05539191,-0.025102682,0.046267137,0.021838456,0.022367813,0.024799861,-0.03794856,-0.0785305,0.053146888,-0.018920243,-0.0031078008,-0.041209605,-0.030650366,5.4610387e-05,-0.06285262,0.10902572,0.063545905,-0.05210552,-0.0060802004,0.08595107,0.013131436,0.048985925,-0.0032918619,-0.032931868,-0.076346464,-0.05312661,-0.07550824,0.03940725,-0.09869495,0.12688428,0.08176835,-0.098597795,-0.07137311,0.059110433,-0.0349351,0.06754515,-0.02017396,-0.016403574,-0.004227005,-0.086032666,0.036352117,0.07018723,0.07043185,0.07380272,-0.064309925,-0.017109204,-0.032504413,-0.055532515,0.019411216,-0.038124215,-0.03218566,-0.0027076334,0.012286932,-0.02192384,-0.023761328,-0.019089282,0.026386898,0.07356507,-0.011341568,0.04184094,-0.020058641,0.03585985,-0.077939786,-0.013569817,0.0075712726,-0.0767769,-0.05764435,0.08299565,0.04820301,-0.012298702,0.0672225,0.0026290636,-0.0037845164,-0.040088043,-0.020794943,0.03710248,0.034977388,0.020891786,0.077988476,0.024302075,-0.026525063,-0.027932815,-0.036566824,0.04317854,-0.022248283,0.044588126,-0.015982067,0.031738155,0.0064691883,-0.019163657,0.06457829,0.009087195,0.030985638,0.036371976,-0.044349853,-0.0154528525,0.060171198,-0.040921558,-0.08985238,-0.038787648,0.0072012725,-0.019869583,0.075382814,0.06461825,0.010690138,-0.028760849,0.02814577,-0.0023017493,0.024170795,-0.035293784,-0.0035467003,0.10265731,-0.074652016,-0.07166405,-0.031525776,0.031382993,-0.046233162,0.0432031,0.07838266,-0.0039052528,0.0025799484,-0.11803328,3.7502156e-33,0.07714811,0.031241843,0.028929446,-0.02180394,-0.0046112607,0.024862686,-0.06832077,0.014221231,-0.018604843,-0.038144283,-0.10974685,-0.07433019,0.063639626,0.024114247,-0.11549874,0.022630326,-0.08177457,0.065984584,0.020710524,0.0413312,0.024820842,0.064713985,-0.0353281,0.039448928,-0.0325835,0.060847364,3.6614245e-05,0.0007663848,0.038897913,-0.030998792,0.0447243,-0.13954931,-0.10410013,0.021963596,0.07093365,-0.06297576,-0.052561037,-0.025433116,-0.02801207,-0.0032936,-0.028267117,0.07783957,-0.036962304,0.0086906925,0.020716745,-0.11711938,0.004111053,0.04943515,0.0030569707,0.035779502,0.020738557,-0.031951357,0.117189385,-0.06725559,-0.06188271,-0.07425557,-0.021026231,0.045102365,0.051854193,0.03741409,0.05591978,0.05290595,0.0048719672,0.0002712342,0.015883507,0.011474937,-0.02317771,-0.038154457,0.08191512,0.076237716,-0.04884765,-0.000927325,0.06815919,0.05316327,0.021316709,-0.08573625,-0.06698025,0.0285183,-0.0028004241,0.0069006137,-0.015103767,-0.031982467,0.024700532,0.011585759,-0.07190377,-0.028416958,-0.0033524137,-0.012523891,-0.009017693,0.031221176,0.05955697,-0.07357971,-0.05382578,0.053988785,-0.005193054,-3.631899e-33,0.09632761,-0.05565967,0.06078964,-0.060911134,-0.044397675,-0.00020759054,0.049804833,0.07088737,0.015728751,0.018008387,0.12289646,0.017161503,0.029445747,-0.027297,0.0069249202,0.012002393,-0.009383644,0.016350389,-0.0002201563,-0.018441232,-0.00045606017,0.03259153,0.0475443,0.011185265,0.03633425,0.05216328,-0.010863467,0.043832473,-0.037700873,0.013496283,0.003619366,0.036400147,-0.047773574,-0.07548122,-0.07845333,-0.004469732,-0.09127261,-0.007512103,0.011630756,-0.032067716,0.064195886,0.070714064,0.045350913,0.053728454,0.0069206594,0.040355504,-0.053553097,-0.0016481365,0.02842234,0.0068225013,0.007348121,0.0069923205,0.011296574,-0.014391808,0.029199034,0.030440293,-0.014938799,0.053631045,-0.034610525,0.040501796,-0.049131405,-0.07419134,0.041905764,0.0326835,0.048352804,0.052535478,0.0066444543,0.040322293,0.05329933,0.051225033,0.10479684,0.020180209,0.0115030445,0.050525952,-0.06512249,-0.08415973,-0.012419314,0.0074651823,0.009867868,-0.018154714,0.025718084,-0.053811785,-0.02664228,-0.078524105,0.044216722,-0.02032863,0.031559218,0.10063739,-0.03444885,0.018944178,0.029484967,-0.06597068,-0.025866045,0.06154754,0.10368247,-5.5401223e-08,0.06686884,-0.04510972,-0.018717377,-0.026677508,0.000602051,0.029435348,0.0014018823,0.0043121153,0.04269523,0.023151997,0.084421754,-0.020329386,-0.025651088,-0.03103426,0.08545347,0.020444127,-0.048695385,0.06203453,-0.015356348,0.03581543,-0.021276012,-0.023075996,-0.17725568,0.035379734,0.09778248,-0.0065719844,0.012646299,-0.0070371437,-0.0027286138,-0.042557206,0.037922136,0.006115796,0.024444632,-0.050407235,-0.06060865,0.03428017,-0.09308547,0.007613539,-0.040744293,0.011221953,-0.038367126,0.033006195,-0.041397486,-0.016444983,0.016477777,0.06456187,-0.050313186,0.020026695,-0.064230695,-0.03616711,0.09346304,-0.089200296,-0.01713146,-0.10029453,-0.13413064,0.03982287,0.0052879225,-0.037095804,0.00074228586,-0.024750486,0.031812664,-0.0032152527,0.12072835,-0.001669946 +4.3.2.2,Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole.,384,0.99999994,0.014218066,-0.1052996,-0.064582154,-0.029876057,0.040174495,0.024862422,0.05651939,0.013380745,0.036523547,0.0404808,0.06422908,0.040001363,-0.04180594,0.11798387,-0.06365956,0.06790614,-0.02851417,-0.004723404,-0.032147434,-0.017533239,0.045992874,0.021643119,0.008493079,-0.009651514,0.0121304635,0.062889464,0.044097226,0.0319287,0.0009959512,-0.10273486,0.03475581,-0.026960583,0.03450321,-0.045531426,0.043748476,0.05111368,-0.09857043,-0.02589057,0.08348191,0.009483648,0.071904495,-0.06578313,0.07063894,-0.029754376,-0.020217327,-0.018050633,-0.025694178,0.028995922,0.10382014,-0.029459734,-0.037220545,-0.049487047,-0.028046668,0.08229564,-0.087190256,0.0351814,-0.15489359,-0.016343895,0.010002804,-0.019296046,-0.03171093,0.04058356,0.02150946,0.03747087,-0.0040430063,0.077711195,-0.020190403,-0.08330734,-0.031172097,0.03791994,-0.012629482,-0.06219647,0.06595182,-0.013886151,0.0024010343,-0.03523551,0.02910865,-0.04805637,0.0069839186,-0.03721783,-0.054514557,-0.01447465,0.047498632,0.023680612,0.03685382,0.08624329,0.039753415,0.016086217,0.048327032,-0.0035255763,0.027362762,-0.018319419,0.09217029,-0.011549727,-0.122772545,0.008325565,-0.072936065,0.09017264,-0.016856734,0.021090947,0.017890736,-0.023173284,-0.024007443,-0.037616182,-0.040197566,0.0006223303,0.020740742,-0.01595218,-0.04530311,-0.0015001297,-0.12176735,-0.06704995,0.030372875,-0.017465545,-0.039356176,-0.037122063,0.013751914,0.037572447,-0.03884543,-0.046702534,0.0471662,-0.037298232,0.044070806,0.009095279,-0.0982287,0.12032754,-0.112351194,1.2915859e-33,0.075718656,-0.027680237,0.090947255,-0.0001453893,0.039803073,-0.009879632,-0.06187043,-0.048961915,-0.06735574,-0.00035863923,-0.10034292,-0.029733043,0.053606637,0.010939574,-0.0024317233,-0.00031510493,-0.028652491,0.011681438,0.04193593,-0.01143653,-0.03185976,0.12763834,-0.11966765,0.019030686,-0.04391633,0.043131243,0.01542705,0.025610177,0.010692693,0.0035956544,-0.024244215,-0.0007587853,-0.16449234,-0.033800878,0.033938788,0.036443386,-0.02411152,-0.02150575,0.0015419483,0.006094478,-0.0016335695,-0.0024855956,-0.081762254,0.03483774,0.08280419,-0.019006792,-0.042500112,0.13309723,0.047864694,0.0567825,0.015173904,-0.076261625,0.11154059,0.04296442,-0.03349472,0.02872813,-0.034793235,0.026172874,0.065028615,0.008734737,-0.012550835,-0.02571172,-0.032188598,-0.056343943,0.022416368,0.015033723,-0.036642462,-0.068812296,0.020619186,0.029605463,-0.039382506,-0.021960452,0.049279395,0.09454573,0.06294617,-0.049539607,-0.0305797,-0.02852491,-0.015111911,0.06831941,-0.028246213,-0.06783136,0.04980559,-0.046165153,-0.03466507,0.039391775,0.008398418,-0.13526396,-0.052891843,-0.0026815203,0.09931696,-0.1200428,-0.062102497,-0.0077706566,-0.0067511774,-1.842966e-33,0.07174065,-0.08325793,0.002942938,0.05283727,-0.0644632,-0.019751327,-0.01228923,-0.017192097,0.014891622,-0.002103198,0.10975826,-0.015384277,0.010663569,-0.024011265,0.017847598,0.01848445,0.0448746,0.030691652,0.03952811,-0.05454509,-0.025191216,0.096441165,-0.013249825,0.06848089,-0.0038707284,0.047982566,0.07412289,0.027993059,0.016032077,0.06504088,-0.07921407,0.014891413,-0.05644544,-0.044296537,-0.025535619,0.03319595,-0.03096228,-0.0181263,-0.034893326,-0.034334507,-0.068950154,0.033543,0.08597005,0.10554753,-0.007513891,0.02465813,-0.04041983,0.05696242,-0.053518884,-0.049802795,-0.009979874,-0.017420366,-0.013462052,0.004369195,0.06846334,0.04264584,0.016224474,-0.031864893,-0.030034335,0.009481094,0.027875295,-0.013023816,0.029269464,-0.057993356,0.08601453,0.0152937835,-0.05291177,-0.0014065899,0.05468314,-0.026217323,0.02893152,-0.009922068,0.059838653,0.04548028,-0.053635042,-0.038905874,-0.034300916,-0.05660121,0.00993437,-0.009553865,-0.0145702,-0.079665855,0.018387089,-0.03679242,-0.016644213,-0.053341407,0.07426222,0.077340506,-0.0029368706,0.07208089,0.0019306693,0.05906075,0.01689289,0.095593564,0.0015957893,-3.1281143e-08,0.07015869,-0.019657504,0.008078271,-0.11050913,0.0005163022,0.07390646,-0.02277365,-0.06741102,0.06900779,-0.047516428,0.033502996,0.08124769,0.010741718,0.07023715,0.051055938,0.03132604,-0.034772504,0.054182183,-0.046374302,0.008369746,-0.08527062,-0.010230912,-0.040641632,0.0037341765,0.012003668,-0.060475405,0.06785,0.07062383,0.0015841881,-0.014973251,-0.041681617,-0.012659814,0.055347417,-0.072508246,-0.008410924,0.10120319,-0.08872552,-0.052458934,0.0003239175,0.039434124,0.014166118,-0.057943728,0.023936585,0.03588528,-0.022647578,-0.0037439696,0.0149895605,0.00029160848,-0.08626982,-0.04583034,-0.01329165,0.015634818,-0.030766793,-0.011047628,-0.09975355,0.0028821938,0.014147385,-0.014973003,0.061220378,-0.02563524,-0.051914815,0.032773137,0.087052755,0.05587765 +4.3.2.3,"This microbial enzyme is involved in the degradation of ureidoglycolate, an intermediate of purine degradation. Not to be confused with EC 3.5.1.116, ureidoglycolate amidohydrolase, which releases ammonia rather than urea.",384,0.99999994,-0.01825165,0.017801668,0.02822764,-0.008322839,0.031002123,0.048495505,-0.007931348,0.019280955,0.0028221032,-5.5877514e-05,-0.07847993,-0.012025345,-0.0029728406,0.04961416,-0.13055743,-0.013541108,-0.07462832,-0.013475649,0.01730023,-0.024024168,0.11962117,0.013553538,-0.064583726,-0.06864935,0.041005403,0.01965569,0.059620816,-0.0490117,-0.022638202,-0.09777268,-0.025583832,-0.035392776,0.037059247,-0.05677071,0.05117942,0.119461946,-0.035435468,-0.0344184,0.04470096,0.040239897,0.046800654,-0.009668736,-0.0382803,-0.044511262,0.009530102,0.039465077,-0.0134374285,0.021518128,0.0075952886,-0.048723616,-0.0652529,-0.009602348,0.05669698,0.013276442,0.046273265,-0.00096358533,-0.05836176,-0.033145115,-0.060157135,-0.0015847245,0.022363951,0.044104,0.05435971,-0.06686799,0.05125863,-0.07275714,0.016326034,-0.033112325,0.009906263,-0.021705247,-0.099040665,-0.03075591,-0.035241444,-0.016162014,0.035895307,-0.01642124,-0.06811918,-0.052521866,0.041718535,-0.04492114,0.06688751,0.002775656,0.08307027,0.007746829,0.023119092,-0.046824075,0.050485514,-0.0937487,-0.010791682,-0.038004704,0.011013536,-0.00716376,0.073824815,-0.004383199,0.0327658,-0.009819646,0.008602045,0.026590038,0.037694056,-0.038297005,-0.048180692,0.093634635,-0.06177929,-0.13554671,0.007983627,-0.004012919,0.023876796,0.11599848,0.11146615,0.037594352,-0.067886055,-0.020611886,-0.022511404,0.030683607,-0.028910762,0.069223024,0.047599822,-0.02389234,-0.10474744,0.013844329,-0.00060078036,-0.019272884,-0.048053823,0.072798796,-0.042374615,0.034674387,0.004045166,1.4750196e-33,0.046439074,-0.0099057425,-0.06394636,-0.029932965,0.021862358,-0.008696691,-0.053752627,-0.03319616,0.050817214,-0.12884586,-0.040096167,-0.012375428,-0.08050247,0.012453093,-0.057609744,-0.009523153,-0.027983794,0.056536466,0.10979287,-0.002381884,0.033487123,0.08545031,-0.03398599,-0.033015154,0.024307728,0.02587799,0.009851437,0.021832854,0.022091623,-0.036309242,0.08793119,-0.053924352,-0.13643931,-0.032198675,0.020605711,-0.034352425,-0.029859832,0.001156358,-0.056590565,0.057016537,-0.031124752,0.031866025,0.028803961,-0.050222855,0.030835677,-0.05539113,-0.051078755,0.078870274,0.0107315425,0.057709903,-0.034047402,-0.01502553,0.09168399,-0.039752297,-0.050487343,-0.0579482,0.01239204,-0.0574291,-0.007313088,0.050313663,0.015964268,0.086371526,-0.013093036,0.031277142,0.0034568843,-0.03535377,-0.03264019,0.023227353,0.056712214,0.07259494,-0.09435808,0.009848547,0.03699523,-0.021651391,-0.025831288,-0.1245514,-0.1256029,0.01804389,0.037782423,-0.06946045,-0.0018870162,-0.0588432,0.012224814,0.022545006,-0.040072333,0.002976257,0.023519602,-0.0063576875,0.004925687,0.027675759,0.023827799,-0.04938524,-0.05026791,0.05774478,0.046659954,-2.5641154e-33,0.15381409,-0.07462584,0.0561429,0.017020052,-0.053662524,0.051018972,0.009094001,0.07620823,0.031076454,0.05707422,0.07270343,-0.031139586,0.0823431,-0.024590751,0.0013665084,0.036438536,0.039650816,0.019998541,-0.06665164,-0.039798453,-0.04021229,0.03875782,-0.038137812,0.024851555,0.027066423,0.05554938,0.02723794,0.018621013,0.031780366,-0.015458043,-0.008079624,-0.010590507,-0.043309674,-0.07075126,-0.05324667,0.009585256,0.0068517844,-0.007342724,-0.06224842,-0.08986609,0.09093641,-0.011364599,-0.022681726,0.06598907,0.06052027,0.123482965,-0.07702121,0.038730934,0.026011076,-0.026007548,0.044624627,-0.017649258,0.034932707,0.02791319,-0.026786052,0.031409543,-0.011208316,0.039905474,-0.040784642,0.03820416,0.0055224765,-0.0066728042,0.039495952,0.0030364462,0.0103606535,-0.020131689,-0.062063478,0.053988494,0.06591158,-0.019821906,0.08862,0.0066511775,0.063620806,0.0018778724,-0.004554695,0.007465379,-0.03574585,-0.03490548,0.04204214,-0.071694285,0.022375382,-0.009981625,-0.038575638,-0.057246976,0.0062072887,-0.026448667,0.06656692,0.11928897,-0.02534998,0.043246433,0.005319459,-0.06541513,-0.10535923,0.023163209,0.013780864,-3.3478337e-08,0.078693636,-0.076290734,0.0021838502,-0.04436925,-8.705851e-05,-0.0009747511,0.048871767,0.08576293,0.060246706,-0.008231963,-0.013043432,0.032443892,0.018496184,-0.013865479,0.09057689,0.02047547,-0.008053107,0.03525557,-0.004290084,0.03643587,-0.12086106,-0.0494713,-0.086331464,0.07980151,0.05423594,-0.027243901,0.1067966,0.027432762,-0.09998482,-0.060872037,0.053315636,0.07331652,0.024222849,0.027862951,-0.044323105,0.073387824,0.040378623,-0.037819248,-0.022650467,-0.034498602,-0.06833133,-0.002167067,-0.060697667,-0.06634353,0.044264693,-0.005476552,0.033372622,0.011305308,-0.013710929,-0.0055086087,-0.02408504,-0.04018678,-0.005491404,-0.08043996,-0.06124259,0.008783933,-0.010140996,-0.10303374,0.019814832,-0.019326366,0.07864176,-0.008495432,0.18188763,0.0009942537 +4.3.2.4,"Also acts on 2,6-diamino-5-formamido-3,4-dihydro-4-oxopyrimidine residues. Brings about the reclosure of the imidazole rings of purine residues damaged by gamma-rays.",384,1.0,-0.0034077477,-0.050000697,-0.026269978,-0.06790086,0.05595484,-0.034826066,0.16357054,0.06905834,-0.016129196,0.035731643,0.06321667,0.033163235,-0.025879327,0.08113158,-0.07338208,0.060861044,-0.05416143,0.015227499,-0.045180403,-0.019762537,-0.01378326,-0.006424922,-0.039172646,-0.03566401,-0.006734736,0.03944132,0.030256271,0.02954832,-0.015835844,-0.095124714,-0.054401293,-0.054034002,-0.0022706224,-0.021131614,0.077343754,0.08245604,-0.031909313,-0.062457874,-0.030958647,-0.022673354,0.0016524838,0.021850752,0.0023369333,0.011346952,-0.005849667,-0.018559262,0.0537894,-0.0139000155,0.07835938,0.01970328,0.031062718,0.027939042,0.023811318,0.07728226,-0.0200581,0.0050116726,-0.102515884,-0.054019026,-0.060235266,0.057564806,0.0060120914,0.02241474,-0.035615273,-0.026884694,-0.016292976,-0.02391312,0.044242308,-0.06940546,-0.031473592,0.0055339406,0.008159958,-0.0621374,0.006366336,-0.039330088,-0.051535204,0.03399225,-0.035744045,-0.08606082,-0.009753931,-0.023260823,-0.044586327,-0.04701397,0.08188049,-0.008092418,0.04217732,0.07451684,0.007433996,-0.00861212,0.07045203,0.06653831,-0.014103161,0.06997705,0.04790746,0.041922662,-0.037409645,0.0656959,-0.012268737,0.04232453,0.05002937,0.024630805,0.07013815,0.034054365,-0.09858964,-0.032795038,-0.05210987,-0.034142386,0.014912075,0.011198971,-0.09205359,-0.0103227515,-0.07472438,0.0014581954,0.039423145,0.0403982,0.046097174,0.07426314,0.06029682,0.019789746,-0.07802173,-0.069775075,-0.003597928,0.0075233956,-0.029636035,-0.027233092,-0.022870017,0.021993985,-0.030492038,1.6987405e-33,0.01842889,0.17256089,0.02773413,0.003128693,0.010259786,0.038279116,-0.08710843,-0.028164785,0.04310464,-0.02007827,-0.08559964,-0.012687851,0.07311435,-0.07116345,-0.042628508,-0.078601815,-0.007599319,0.13538378,-5.0890038e-05,-0.00036223192,-0.0030605188,0.12228861,-0.022223322,-0.027835766,0.0036293543,0.10148428,-0.042220727,0.04290032,0.045933273,0.021633018,-0.014018931,0.031811003,-0.060364004,0.008586141,-0.01786102,0.027265027,-0.08541287,0.0728788,-0.026538659,0.06516662,0.044445943,0.009158707,-0.12698194,0.042743333,0.046493962,-0.09940959,-0.00790963,0.123157986,0.03930635,-0.03976385,-0.036928773,-0.08683597,0.06383325,-0.024008559,0.03218613,0.048480287,-0.03740659,-0.022313684,0.039271757,0.005522781,0.04797611,0.0038523746,-0.021045063,0.03526495,0.025276078,-0.046623677,-0.054265324,-0.029355709,0.019145522,0.051981967,-0.052323125,-0.021736542,0.013912924,0.022849593,0.0985604,-0.07584068,-0.11642613,0.07900279,-0.04434514,0.0021186997,-0.041941475,-0.029967029,0.061601285,-0.04728542,0.029889867,0.079712175,0.06243792,0.035502918,0.005174247,0.023228617,0.12557302,-0.047237083,-0.0033151156,-0.10904461,-0.023650628,-1.4395537e-33,0.049754106,-0.08096732,-0.04495561,-0.015690215,-0.047208164,-0.020899938,-0.018519528,0.074940555,0.010712131,-0.06238835,0.022221237,-0.0067600105,-0.083326936,-0.034676276,-0.048768077,-0.03700734,0.015562978,0.047509562,0.025030479,-0.09162641,-0.022559024,-0.017729402,0.033312112,0.07017012,-0.012202898,0.06305978,0.03751809,-0.11966408,0.087385856,0.043534797,-0.08162869,0.0002769185,-0.049435787,-0.0074963165,0.10363937,-0.011531342,-0.03758679,-0.018110529,0.013981641,0.022069924,-0.008980732,0.055452924,0.0217212,0.052398138,-0.021396326,0.03410637,-0.06355531,0.06752805,-0.03621463,-0.08791266,-0.017557088,-0.093420215,-0.033354763,-0.0009991423,0.045035563,0.026559547,-0.012176596,-0.029449327,0.021499615,0.08558067,-0.045293815,-0.029172074,-0.005172576,-0.0247593,0.091224164,0.04148642,0.03401264,0.07421602,0.026632449,-0.01956132,0.031678703,-0.03890759,-0.016565092,0.01615083,-0.018762471,-0.027381103,-0.032479886,0.055806693,0.01690484,-0.054067805,-0.0204848,0.0019517059,-0.05641355,-0.048965465,0.010180387,-0.056523573,-0.043665223,0.024546532,-0.011778974,-0.0577882,0.021939052,0.016524026,0.03468744,0.110975474,0.043373983,-3.3114617e-08,0.08537077,-0.04123386,-0.01940508,-0.049233764,-0.010584011,0.020990364,-0.028012691,0.08259427,0.13016301,-0.06042891,0.041245773,0.09419731,0.12984644,0.029281432,-0.024557948,0.039067533,-0.021997795,0.022873025,-0.010921606,-0.009742884,-0.02997718,-0.023317736,-0.053269748,0.024800502,0.025693819,0.025120398,0.06045599,0.003673047,-0.05427661,-0.011222303,0.02617757,-0.012493748,0.060078267,-0.04929398,-0.015768755,0.05326519,0.019649427,-0.057238035,-0.034389284,-0.035991628,-0.023261944,-0.050284203,-0.02117547,0.0030570657,-0.014373572,0.0061774193,-0.032834064,0.04346183,-0.0329487,0.035245396,-0.06797862,0.046040565,0.025867833,-0.104096636,-0.093550235,-0.032680344,0.068962574,-0.052911095,0.066063516,-0.06114878,-0.011851931,0.06321028,0.08120585,0.011815478 +4.3.2.5,"Requires zinc. The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide. In mammals, the two activities are part of a bifunctional protein.",384,1.0,-0.08226334,0.015545995,-0.025665946,-0.01524955,0.058310915,0.023236532,-0.026209172,0.021722192,0.013013503,0.038767193,-0.024871336,-0.0049646976,-0.00021468989,0.06458925,-0.0025051222,-0.013936385,-0.005931713,-0.019468032,-0.034059886,-0.031920902,0.033254236,0.030618928,-0.020577619,-0.039785244,-0.02934512,-0.043016236,0.064629674,-0.023971656,0.027972098,-0.0042361678,-0.020830814,-0.038020663,0.08087772,-0.06171452,-0.023849666,0.08264392,-0.018272417,-0.034522064,0.03325662,0.014353831,0.040611893,0.061454654,-0.025220733,-0.08070786,0.02407992,-0.034279004,0.053121295,-0.007486619,0.005196227,0.008515008,-0.027911564,0.0064825327,-0.0044741686,0.0029781077,-0.0013269312,0.02094307,-0.10989026,0.00031914783,-0.034260295,-0.063848354,-0.057957243,-0.06552372,0.010823341,-0.04055337,0.07231809,-0.078064,-0.016689107,-0.09257573,-0.024240348,-0.03685017,-0.028250368,-0.09931246,-0.037756156,0.0087821195,-0.08570586,0.012432041,-0.00016406243,-0.068594806,0.04371552,-0.02668086,0.020808764,-0.018263062,0.03150143,0.083652206,0.085036546,0.09943313,-0.033159953,0.020529091,-0.03995064,0.0020871956,0.048655305,-0.062109478,0.014479747,0.016417587,-0.02205377,0.004703853,0.0012228874,0.020279255,-0.012277155,0.047586188,0.0040119733,0.1177369,0.0360147,-0.04220125,-0.044645786,0.067108534,0.027978595,0.09302235,-0.0018249803,0.04326223,-0.010321407,-0.04063078,0.025939304,0.010367608,0.008379224,0.08543403,0.07589758,-0.045994416,-0.041129842,-0.07458584,0.029643707,0.011134879,0.032474425,0.0711103,-0.035608906,0.12090857,-0.030905725,1.765995e-33,0.029964564,0.006694021,0.025881402,-0.016954428,-0.0075248186,0.0700213,-0.05614298,0.052770074,0.034029905,-0.07516554,-0.042474758,-0.01279021,0.07799418,0.0062395255,-0.09161047,-0.063287646,0.03142997,-0.04343893,0.051808782,-0.0015183196,0.030206108,-0.0011751199,-0.021481253,0.027855502,0.04193186,0.014273871,-0.033114515,-0.00459127,0.027643757,-0.030320572,-0.041615512,-0.07071529,-0.11003903,-0.0060558687,0.100848734,-0.03489334,0.0067166653,-0.04423418,0.06658718,0.0004967394,0.0068432824,-0.025422243,-0.061423194,0.013877657,0.06671428,-0.023970816,-0.028801553,0.1195201,0.0044530067,-0.00081011705,0.121760726,-0.008772674,0.08008539,-0.04724498,-0.112972714,0.038206946,0.03185965,-0.06818253,0.036075503,0.10532306,-0.014762589,0.021579491,-0.029198831,0.0778404,0.0392254,0.027688865,-0.13598433,-0.016153874,-0.043805223,0.069013715,-0.041818276,-0.014409336,0.09524063,0.01873944,-0.0063461554,-0.05585442,-0.018550253,0.006179539,0.10423129,0.0009070953,-0.024208147,0.013895654,-0.06566865,0.029375875,-0.018488875,-0.03994669,0.0038586757,-0.11891556,0.016738487,0.013570596,0.03725394,-0.030794976,-0.07853876,0.04136796,0.027841588,-4.2065738e-33,0.06384726,-0.03876878,0.00548698,-0.0529297,-0.013102169,-0.00037210665,0.022658845,-0.12051308,0.069540724,-0.07494695,0.052684315,-0.03631546,0.058892783,-0.009488161,0.044208538,0.06697174,-0.10363679,0.06558538,-0.029674778,-0.06594165,0.01578406,0.03642034,0.034132153,0.03771082,0.04577207,0.029458996,-0.01941885,0.04721704,0.082939066,0.081487596,-0.043212015,0.03573455,-0.053867504,-0.07782879,-0.025240581,0.08033485,-0.064531706,0.04288801,-0.029352356,-0.10067779,-0.016842779,0.030535989,-0.014374462,0.14670996,0.09914284,0.08391602,-0.041654136,0.014228041,-0.10969223,-0.039031938,0.019663196,0.012941925,-0.017945435,0.011418982,-0.0012784057,0.07370731,0.019833669,-0.007398233,0.0345698,-0.014878514,0.036752805,0.00041634327,-0.0507865,0.018618736,0.01686278,-0.061331496,-0.009398198,0.05001284,0.08000076,0.016300736,0.06971573,0.039191373,0.08125522,-0.025101386,0.015922759,0.09439632,-0.078915164,-0.054418992,-0.008412009,-0.028124133,-0.038849335,0.042060822,-0.0258096,0.0070397034,-0.07355058,-0.06983173,-0.012368143,0.072414756,-0.06670192,0.010424494,-0.086038165,-0.07305446,-0.026969096,0.088698424,-0.03381925,-4.1842945e-08,0.010224592,-0.0017270547,0.040153872,-0.094915934,-0.024970647,0.043935634,0.016426379,-0.04265782,0.020747948,-0.050342865,-0.010808738,0.041118305,-0.025351629,0.03719844,0.02482789,0.07479826,-0.022006247,0.0468004,-0.036241367,0.00343548,-0.05350813,0.0117076645,-0.110154815,0.041460507,-0.040836923,-0.10382874,0.004954475,0.10137164,-0.07059816,-0.0046437862,0.026337665,0.017581541,0.0246295,-0.014855128,-0.055208705,0.009071108,0.0252999,-0.048149947,0.015156113,-0.06598495,-0.056413017,0.024372235,-0.05048505,-0.012960563,-0.030015035,-0.055444296,-0.015548155,0.0120464135,-0.010469166,0.0510376,-0.014074388,-0.05748501,-0.025215497,-0.05570021,-0.020488707,0.005271495,-0.06293569,-0.0976232,0.014789746,-0.04800958,-0.022010673,0.055981133,0.19917454,-0.049681455 +4.3.3.1,"Requires Ca2+. Eliminates 4-nitroaniline from 4-nitrophenyl-3-ketovalidamine, or 4-nitrophenol from 4-nitrophenyl-alpha-D-3-dehydroglucoside. Involved in the degradation of the fungicide validamycin A by Flavobacterium saccharophilum.",384,0.99999994,0.012653608,-0.011826888,-0.047447443,-0.02917002,0.037835956,0.034635905,-0.037153713,0.051454227,0.1064416,-0.004937393,0.012850809,-0.014360799,-0.052640494,0.061163407,-0.122713834,-0.009893911,-0.025408879,0.13172923,-0.07242116,-0.028595895,0.0188609,-0.01236502,0.03364049,-0.014395486,-0.014637192,0.032749284,-0.049529262,0.010787701,0.01348082,-0.08449703,0.10637039,0.045448184,0.054379426,-0.08532759,0.03537017,0.0126079,-0.06918285,-0.052791227,0.025719967,0.0062516313,0.026268654,-0.023770424,0.012554996,0.04697539,0.037419073,0.015553732,-0.08741209,0.01851298,0.07662277,-0.023426238,0.0057060653,-0.01677355,0.006927439,0.0746652,0.041888446,-0.003908004,-0.019436417,0.032283522,0.023480015,0.06924848,0.079052985,-0.02710873,0.03887771,-0.06700193,-0.03968531,0.016901048,-0.018013122,-0.044278935,0.0540975,0.05257018,-0.05050249,-0.009923014,0.03547891,0.029257458,0.013074965,0.067842044,-0.023344135,-0.061880663,0.050770335,-0.06931844,0.07338077,0.033829246,0.0380575,0.07625461,0.06808449,0.028982475,0.012620043,-0.08543221,0.11078954,0.095337346,0.0686532,0.10599182,0.068871595,0.008623094,-0.07974952,0.011875881,-0.03873208,-0.02750437,-0.0789598,-0.00083850854,-0.0077195433,-0.030645672,-0.07145484,-0.061367903,-0.10536799,0.0030397556,0.010295201,-0.014597153,-0.025673164,0.023741065,0.07076805,-0.03594222,-0.062209487,-0.07695374,-0.0137447715,0.09245755,0.11179925,-0.026818007,-0.050879404,-0.08082404,-0.068313114,-0.033552907,0.037649587,-0.00050927175,-0.06904502,0.04155081,0.03683617,7.5072454e-33,0.053629167,0.07156916,-0.05172528,-0.017990068,0.07768474,-0.066279635,-0.055876527,-0.011305962,0.031730138,-0.06331373,-0.021194106,-0.09184494,-0.07314626,-0.042232208,0.05023616,0.028956776,0.02619381,-0.03626502,0.016357118,-0.008489082,0.06499584,0.022415046,-0.034060493,0.013822839,0.008564044,0.02121941,-0.053232547,-0.021406474,0.08911476,-0.016641553,0.015019936,-0.08885272,-0.07152635,0.07142773,0.018932752,0.055401005,-0.042096317,0.0017926387,-0.03182223,0.09068572,-0.09240424,0.045662526,0.043628063,0.007133495,0.07603539,-0.07266811,-0.033493973,0.091568016,0.086735696,0.052346412,0.039559957,-0.0068950183,0.08522858,-0.0062934696,-0.031218363,0.011183497,-0.023817746,-0.007325462,0.043181293,-0.035523485,0.024956891,0.013213844,-0.024212882,0.0049551507,0.057967532,0.011977427,-0.03139008,-0.0656042,-0.015627153,-0.08046032,-0.050869476,-0.05197692,0.060507376,0.0062042666,0.039421923,-0.047083512,-0.066778086,0.016137568,0.02404066,0.022597147,-0.013883502,0.01884511,-0.017480459,0.012630064,-0.019275667,0.072685115,-0.034858417,0.0077411267,0.026015019,0.003850042,0.01818887,-0.05981786,-0.018504405,0.050619304,0.010385009,-5.6247023e-33,0.0606737,-0.01142052,0.043357816,0.01669421,-0.033146605,0.054324705,-0.05497294,-0.061550725,0.04211635,0.01317073,0.09622395,-0.049097467,-0.0076902416,0.064409494,-0.013623954,0.005925199,0.0015477851,0.05966703,-0.077905394,-0.059072692,-0.0002277237,0.117855,-0.05928558,0.071482636,0.01712712,0.028599488,0.04922296,0.00022651424,0.0274483,0.04519909,-0.009679493,0.025213914,-0.08033099,-0.0667165,-0.013227584,0.01767232,-0.010825546,0.020643542,-0.08427161,0.032797445,-0.037567172,-0.0025801647,-0.014251399,0.062736504,-0.004380636,-0.011749308,-0.0458586,0.06345003,0.058942467,0.0171709,0.023331719,0.019712346,-0.08188872,0.05764856,0.009394659,0.033138577,0.053981096,0.030718027,-0.011783084,0.00994829,-0.04005663,-0.07169281,0.010225388,-0.031619545,0.08700639,0.075399175,0.000841239,0.108298205,0.08531615,-0.106266506,0.0061234892,0.057532616,0.0490978,0.04560217,-0.031120809,-0.033171605,0.028101368,-0.0028240317,0.022550885,-0.018317115,0.022419618,-0.05148198,0.028547449,-0.054135557,-0.021117328,-0.06910322,0.020308675,0.02418865,-0.03294403,0.022817243,0.042103343,0.0054691066,-0.0075398725,0.038204655,-0.041580435,-4.4371028e-08,0.018575963,-0.016905352,-0.030797068,-0.06204124,0.018682804,0.008433421,0.026493276,0.03043353,0.020412575,-0.07612013,-0.046862274,0.12954487,-0.053103726,0.03168106,0.04185937,-0.022008862,-0.019800449,0.0014293047,-0.06170488,-0.03869366,-0.07034175,-0.050420873,-0.16289803,-0.024923755,0.0013816275,-0.041979812,0.047857996,0.032811455,0.022479266,0.04942193,0.093980275,0.008219875,-0.0075785965,-0.06479294,-0.0702026,0.010807776,-0.006777167,-0.041615948,-0.02809323,0.029683061,-0.0860184,0.053027872,-0.06532412,0.022255177,-0.029545387,-0.045154043,-0.024302777,-0.027275924,-0.077305324,0.0630138,0.011092803,-0.03146652,-0.01524048,0.005756978,-0.14040962,-0.047327314,0.1083722,-0.00087503146,-0.075037524,-0.07713345,-0.023332274,-0.044790667,0.17117059,0.006661663 +4.3.3.2,"Catalyses a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine [4,5]. Involved in the biosynthesis of the monoterpenoid indole alkaloids.",384,1.0,-0.0060080285,-0.042499438,-0.05706718,0.00082892826,-0.062270507,0.046716686,-0.006481211,0.0031162156,0.07832359,0.008515246,0.08014874,-0.11186657,-0.01570162,0.026863685,-0.028062578,0.059427794,-0.010752476,-0.0086276755,0.03686303,-0.011799693,-0.043585997,0.009673329,0.0045997417,-0.0013866305,0.01205736,0.0356655,-0.015127162,-0.005050467,0.013961296,0.0034586927,0.019042937,-0.031026771,-0.099483564,-0.013432215,0.00090602046,0.0013487623,-0.09527382,0.017719077,0.15441208,0.00340435,0.00016970454,-0.03418037,-0.03547262,-0.03263369,-0.02499032,-0.05142003,-0.025190333,0.024022674,0.031160863,-0.062232044,0.013519658,-0.040424585,-0.03736264,0.015257799,0.066713825,-0.038454447,-0.0109446505,0.041134726,-0.019922307,0.060066737,0.047456633,0.046602774,-0.04850489,-0.026406007,-0.020621335,-0.06613921,-0.020764368,0.0005859432,0.065931015,-0.016949208,-0.004967065,-0.08399013,-0.047287237,-0.0025315061,-0.034435667,0.013474669,-0.027072338,0.038876694,-0.06520989,-0.11095618,0.023650985,0.0075588683,0.03247802,0.14011772,-0.008535684,0.02307389,0.047055535,0.10620819,0.070307404,0.014330413,0.05290058,0.013259073,-0.024042517,-0.030482886,-0.04259426,0.043834403,0.008595356,0.02079316,0.011241206,0.012041084,0.0615774,-0.01371516,-0.14677216,-0.10228695,0.0026663127,0.011167364,0.0058718706,-0.0016645552,0.07622706,-0.07083755,-0.021458212,-0.032628693,0.03529536,0.052641127,-0.060762912,0.019295081,-0.005234247,-0.024684556,-0.008505226,0.021555524,0.040503833,0.08545282,-0.006019374,0.08408786,-0.008339075,-0.012774765,-0.005034718,1.6418095e-33,0.08892815,0.010786862,0.023856025,0.018557008,0.0071175303,0.020015895,-0.07215166,-0.00095337426,-0.044129,-0.05631577,-0.1349091,-0.07272937,0.016938517,0.002325927,0.035362232,-0.029113282,-0.124385566,-0.03537141,0.06980927,-0.03159067,-0.11429433,0.005744059,-0.060484804,0.03125078,-0.054663118,0.088340335,0.0008183238,0.017274085,-0.028388714,-0.021782622,-0.05394749,-0.0025681027,-0.06329537,-0.013239076,-0.03608089,-0.061621193,0.028877262,0.003997414,-0.06994739,0.04328035,0.035266902,0.11249471,-0.04157686,0.052331563,0.08942851,0.05148748,-0.048103593,0.15003589,0.07901077,0.0610732,-0.015734099,-0.077256225,0.06517847,0.037095815,-0.09415537,0.05111806,-0.021115018,-0.009936455,0.011637124,0.03665214,-0.048314027,-0.013366999,-0.0003875454,-0.02317008,-0.052428655,0.04436374,0.0061108507,-0.011747489,0.0034804353,0.028044429,-0.06863934,0.071805805,0.05310191,0.0017157934,0.053444136,0.030511254,0.041707683,-0.022504147,-0.026012206,-0.0054032793,-0.009949898,-0.0210334,0.012309557,-0.051993337,-0.014303606,-0.028112164,-0.042525098,-0.038107794,-0.019162713,0.093650475,-0.029675813,-0.024211831,-0.13335443,0.040742233,-0.07162283,-2.884397e-33,0.038612925,-0.085154355,-0.0145936385,-0.08621195,-0.07465633,0.023807516,-0.0788984,-0.03181429,0.029926315,0.059406895,0.06426408,0.0030323507,0.12756746,0.026199745,-0.043371968,-0.062443025,-0.0075889276,0.10181709,0.029577497,0.0022280265,-0.0012360851,0.04054052,-0.083990805,0.053507764,0.04853284,0.056474768,-0.019560745,0.01945874,0.037896242,0.06260026,0.125743,-0.11742156,-0.06772445,0.0063139386,0.07695509,0.081003085,0.042330656,0.06538244,0.024400117,0.09451056,0.0011210617,0.030376704,0.043661952,0.07870507,0.09022271,0.006980051,-0.09095124,-0.016843723,-0.102344535,-0.042200975,0.05576786,-0.04420318,0.015813772,-0.009603528,-0.002926504,-0.019545093,0.029316105,-0.065595955,0.047123924,-0.03233032,-0.031902865,-0.04766396,0.0084957415,-0.04401395,-0.05002588,0.015640736,-0.004885689,0.059916522,0.06968947,-0.036785096,0.06309304,-0.05483455,0.013938249,0.028199084,-0.013940882,-0.029315626,0.03376103,-0.07399677,0.026442606,-0.010030465,-0.0013109472,0.04846324,0.0710715,-0.07563981,-0.02484024,0.03470477,0.029872304,0.10601262,0.05064799,-0.009285421,0.031853735,0.0449063,0.069219574,0.06440057,0.06382044,-2.982259e-08,0.0560299,-0.017739296,0.022158977,0.07476854,-0.015790788,0.017516213,-0.008536456,-0.017278584,-0.015244284,-0.072316475,-0.010851934,-0.032442354,-0.033291165,0.064488694,0.030282894,0.039209712,0.013964949,-0.025456088,-0.0032189738,-0.03432505,-0.088391416,-0.007751797,-0.020532906,-0.035125367,-0.04170857,-0.10449999,-0.024654675,0.004807354,0.022865469,-0.07439475,0.031238738,0.036303915,-0.009273088,0.018640546,-0.044119086,0.041589428,-0.051141877,0.0018108892,0.073576435,-0.005863015,-0.0705728,-0.12301646,-0.026012287,-0.0163127,-0.02530311,-0.02602682,0.05061744,-0.033274837,0.032362573,-0.0024126326,0.044598505,-0.010670453,0.03920621,0.013974563,-0.11103262,-0.017988686,-0.049910188,-0.0015507753,0.0017811254,-0.11300828,-0.02859616,0.065309316,0.07265607,0.041925937 +4.3.3.3,The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 4.3.3.4 deacetylipecoside synthase. The product is rapidly converted to demethylisoalangiside.,384,1.0,-0.019186813,-0.058095906,-0.03393945,-0.04212378,0.0075666667,0.073503904,-0.065079994,-0.004354789,-0.01426204,0.015283785,0.060903598,-0.07253144,-0.033727888,-0.08779934,0.026447367,0.07517117,-0.01462419,0.080805756,-0.08994368,-0.07366947,0.036515694,0.0067989533,0.015454681,0.05352744,0.046298385,0.017913274,0.03613784,0.026511926,-0.031007148,-0.10849327,-0.021821357,-0.026594052,0.05901921,-0.0795617,0.078875504,0.056172606,-0.10934391,-0.102141134,0.13086364,-0.06395319,0.10395941,-0.005665453,-0.0412062,-0.025522804,-0.020232473,-0.06730369,-0.028097223,0.04843508,0.0804688,-0.004048145,-0.029162468,-0.04537492,-0.015673447,-0.08175333,-0.049453977,0.020610647,0.006723042,0.015043301,-0.0001744798,0.054969363,0.08427851,0.0392582,-0.010683248,-0.017799456,-0.03810856,0.039459288,0.0391855,-0.07228609,0.07220971,0.00040628912,0.00905088,-0.033563692,-0.082032226,0.065872185,0.024334565,0.027698927,0.010020099,0.0030419528,-0.01139053,-0.024041478,0.04671156,0.014389276,0.025222253,-0.007818794,0.0032172434,-0.008704156,0.041575767,-0.02949822,0.014246463,0.051068347,0.07048763,-0.034640513,0.019663252,-0.06949863,0.0009695749,0.025097342,0.003048541,0.053372458,-0.0043190396,-0.022570781,-0.011114374,0.02259272,-0.04144061,-0.05109881,-0.0471488,-0.026627999,0.021109665,-0.034387182,0.030831609,-0.025397345,-0.028843384,-0.10442456,0.06296075,0.05082295,-0.055390112,0.056789417,0.052110992,-0.03512472,0.0037467268,0.0067402897,0.0672666,-0.023845708,0.10261842,0.03070736,-0.034540012,0.04960305,-0.090831555,4.0988294e-33,0.08800865,-0.0064724274,0.04257189,0.047769412,0.018407548,0.0013942188,-0.07367032,0.015398336,-0.08177709,-0.032850083,-0.10370589,-0.026980264,-0.027561769,0.044983502,0.007970178,0.029685093,-0.024574196,0.06610847,0.07201062,0.02612993,-0.011077803,0.039388467,-0.061340675,-0.01962102,-0.06661926,0.030808896,0.026676705,-0.02918228,0.09212082,-0.00071682973,-0.013382095,-0.030864114,-0.09184057,0.019641569,-0.02468116,-0.024918605,0.0039156866,-0.044806246,0.04332619,0.059140638,-0.023059327,0.086698756,0.023221686,-0.06131371,0.03121642,-0.006789511,0.010525796,0.0034642154,0.12186294,0.010613121,0.034658745,0.03598475,0.18716927,-0.021696562,0.04175939,-0.01456577,0.01100003,0.09858651,0.06224637,0.039808083,0.06925673,0.09224273,0.05964867,-0.023682814,0.063785054,0.011670379,-0.07036198,-0.029456507,-0.020239415,0.0022748355,-0.029145977,-0.04394685,-0.013466806,0.03745182,0.061133098,-0.05855432,-0.0978326,-0.007899461,-0.011430812,-0.045367282,-0.050992567,0.0438644,-0.041734744,-0.021998584,0.003490272,0.013962467,-0.039580107,0.055449214,0.041345388,0.03207593,0.04690011,0.015381228,-0.12723069,0.05635748,0.06266504,-4.0661257e-33,0.021223849,-0.05429877,-0.011200504,-0.015146607,-0.080702566,0.0043745246,-0.014713309,0.050068725,0.09284888,0.07006635,0.12228121,0.0074650887,0.049262136,-0.06846006,0.03278808,-0.06878435,-0.011285387,0.03130296,-0.041604973,-0.0465644,-0.014093164,0.012585077,-0.00072104955,-0.020337583,0.050183717,0.015319277,-0.027777402,0.06652317,0.019422289,0.020645322,-0.023133934,0.09038443,-0.06021075,0.01220235,-0.10388306,-0.017131861,-0.021543242,-0.016505888,0.028137015,0.06778846,-0.053592414,0.06149039,0.05090292,0.031145368,0.07455326,-0.008309112,-0.047030725,0.023608562,-0.017864404,0.01913045,0.046162605,0.005203895,-0.032997258,0.037004545,0.024514392,-0.004933466,0.001981989,0.01927454,-0.036546957,-0.03459492,-0.011041463,-0.0065759127,0.013714604,-0.0067976527,-0.0015754487,0.12953421,-0.043391015,0.08477315,0.033942103,-0.024872098,0.066403,-0.02709145,-0.021750016,0.04057442,0.07245359,0.024233326,-0.025323017,-0.07255737,-0.024455054,-0.12791435,-0.031782486,-0.0060233176,-0.024917245,-0.06060539,-0.056579508,-0.055638544,-0.009165012,0.055393837,-0.032937407,0.080047034,0.013192294,-0.106201924,-0.12334061,0.12062418,0.03551002,-3.320809e-08,0.019711679,-0.014001725,0.03149802,-0.05381461,-0.043912683,-0.009525211,-0.011402277,0.03127367,0.060413674,-0.055863924,0.012349254,0.004966267,-0.03327821,0.072880365,0.03722664,0.0018112763,0.03592714,0.07154256,-0.038285937,-0.0011196164,-0.03629632,0.0032597175,-0.063068144,0.005643053,0.011522745,-0.075558886,-0.0082182605,0.019581111,-0.035461526,-0.011328393,0.009255292,0.02437678,-0.006138369,-0.04240891,-0.06636434,-0.012092444,-0.050731134,-0.014407945,-0.025296869,-0.023449756,-0.040325593,-0.101571426,-0.13302691,-0.034541458,0.0066143908,-0.030436462,0.056559645,0.024595108,0.006129767,-0.02119148,-0.0092402715,-0.047425568,0.07421283,-0.0658008,-0.08009519,0.030156868,-0.023762979,-0.04344295,-0.012987137,-0.049329914,-0.013580624,-0.0179404,0.19493057,-0.06174813 +4.3.3.4,The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 4.3.3.3 deacetylisoipecoside synthase. The product is rapidly converted to demethylalangiside.,384,0.99999994,-0.024735445,-0.054478798,-0.03755787,-0.047021654,0.026003676,0.07785244,-0.043469664,-0.007955307,-0.016598318,0.0127352,0.04867682,-0.08981683,0.005429387,-0.091854446,0.014972019,0.05675561,-0.01982387,0.0671177,-0.093125336,-0.08611589,0.025341129,0.01974488,0.014273692,0.044074196,0.030195756,-0.008716953,0.031504445,0.029731618,-0.027375761,-0.09994438,-0.028154265,-0.003865806,0.043256085,-0.073648594,0.06872686,0.054456804,-0.10345703,-0.10378336,0.11614686,-0.05554078,0.093648374,-0.0015320614,-0.02649568,-0.03187013,-0.03582576,-0.07066447,-0.020158114,0.043919798,0.08345465,-0.010699684,-0.03289755,-0.034178663,-0.012259151,-0.07372944,-0.041130126,-0.010706663,-9.291794e-05,0.000899473,-0.013056016,0.057315093,0.08618011,0.04103554,-0.0067246784,-0.025420828,-0.05837643,0.038061038,0.028542748,-0.07375064,0.06187909,0.00047205843,-0.0022495557,-0.045868766,-0.06875454,0.06417694,0.031563748,0.024496656,0.015983338,-0.002359037,-0.021591077,-0.027044006,0.021925919,0.016298328,0.028997347,-0.0032681765,-0.015265933,-0.009507011,0.058258686,-0.019994771,0.02969689,0.05122588,0.066251546,-0.04299915,0.029728483,-0.05768887,-0.018309359,0.02340739,0.0015101968,0.0418705,0.012548169,-0.01672096,-0.026403723,0.012226001,-0.027486447,-0.050647497,-0.057004172,-0.04696749,0.007356848,-0.010276898,0.02419752,-0.04476722,-0.017668925,-0.089528434,0.076907724,0.0752098,-0.061869986,0.05697809,0.07876355,-0.050271712,0.0020038811,0.0024911226,0.073960915,-0.0026801405,0.11069586,0.03399365,-0.023953516,0.046031937,-0.09128385,4.059925e-33,0.07537468,-0.0067625176,0.07701619,0.0631896,0.020021291,-0.00020561091,-0.075677775,0.016938252,-0.07448368,-0.04403368,-0.105362654,-0.008072367,-0.022290248,0.04911861,-7.260011e-05,0.032292593,-0.016311342,0.05877754,0.054407593,0.03208164,0.013931322,0.043693613,-0.059061408,-0.014783262,-0.057323128,0.038031533,0.06804778,-0.03442405,0.102255285,-0.0020210033,-0.027774077,-0.04259408,-0.078699365,0.019441374,-0.019308014,-0.01307017,0.019927217,-0.03606571,0.045751996,0.046249904,-0.012677058,0.09707677,0.01876386,-0.067109175,0.025314484,-0.009212451,0.0023162742,0.005542874,0.1090366,0.024875037,0.034537207,0.028058702,0.19855998,-0.017391996,0.028191956,-0.003226324,0.015250891,0.09783513,0.07514917,0.04745752,0.06534887,0.067412265,0.055889547,-0.023238698,0.06553372,0.020285824,-0.0657535,-0.045437407,-0.026488716,0.0012595092,-0.050744433,-0.03240181,0.006156307,0.05259119,0.07724416,-0.06341611,-0.09951391,-0.0030669249,-0.015640672,-0.028246649,-0.057322398,0.041084472,-0.05346268,-0.009863464,-0.005147777,-0.0023570433,-0.043781713,0.06335155,0.043997567,0.032681722,0.03493493,0.0077062063,-0.13376701,0.052076235,0.043486353,-4.054052e-33,0.028297098,-0.06525127,0.010986929,-0.0013209097,-0.070725836,0.00027405802,0.005678417,0.06651135,0.09563587,0.05448771,0.13141842,0.024407128,0.059002783,-0.05578118,0.019844687,-0.069336556,0.012224993,0.032578584,-0.050792884,-0.043542773,-0.032396954,0.0041335467,-0.011536694,-0.046629556,0.04470605,0.019200226,-0.026836453,0.100871466,0.009764052,0.019986449,-0.013741024,0.0818514,-0.06511439,0.007050996,-0.12378143,-0.016869593,-0.006897177,-0.022241976,0.035124302,0.07732512,-0.05143038,0.04970704,0.04065088,0.032640703,0.07116395,0.00014324606,-0.059510894,0.020725537,-0.007918612,0.010342575,0.054144904,-0.0049937963,-0.02734734,0.021702852,0.028327955,-0.01765015,0.008433748,0.006621301,-0.04537632,-0.019876549,-0.007152386,0.0068717315,0.010120272,0.0027223057,-0.032253854,0.12604405,-0.039474484,0.06455255,0.049883597,-0.036765523,0.08058062,-0.02974605,-0.0073761316,0.03485176,0.06807322,0.029638782,-0.04327592,-0.058246143,-0.02779562,-0.122361355,-0.03668076,-0.019700047,-0.034923334,-0.043416012,-0.0621932,-0.036298543,-0.0018049062,0.056996375,-0.01569672,0.051251262,-0.009808106,-0.09988305,-0.13634141,0.12230684,0.03940944,-3.4216182e-08,0.0141265355,-0.0313476,0.026580678,-0.04554814,-0.072888926,0.00900106,-0.0006331212,0.026272174,0.063627355,-0.050795544,0.031044487,0.0041160444,-0.033784084,0.066328906,0.016006123,0.0010427872,0.043030944,0.074800014,-0.02743097,0.0043438035,-0.040241733,0.0006774757,-0.05734518,0.004509279,0.01744581,-0.069586515,-0.011791289,-0.006738423,-0.037751775,-0.050646845,0.0054909145,0.027605532,-0.013155011,-0.022584986,-0.089947104,-0.01328978,-0.065251105,0.0018322103,0.0046376972,-0.015039402,-0.0150960935,-0.07945016,-0.14879411,-0.041543588,0.0029220385,-0.00714506,0.032361638,0.028439857,0.008474982,-0.037453774,-0.0032286341,-0.020002717,0.070077375,-0.060432885,-0.0756449,0.042262923,-0.02876215,-0.06538776,0.0006257557,-0.052301038,-0.020205824,-0.017327536,0.18016298,-0.050356437 +4.4.1.1,"A multifunctional pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses the conversion of L-homoserine to 2-oxobutanoate and ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of L-cysteine to pyruvate, hydrogen sulfide and ammonia.",384,1.0,-0.018047042,-0.06033958,-0.023391107,-0.043502804,0.06572534,0.07138879,0.019287175,0.024797775,-0.010313551,0.07916625,0.019721963,-0.034402028,-0.051447388,0.041804794,-0.046470262,0.116040595,-0.0982487,0.038228694,-0.011867004,-0.010028619,0.086756706,-0.006464877,-0.08978254,0.033184573,0.010167855,0.07595306,0.039486855,0.019966811,-0.046316862,-0.083526604,-0.071292035,-0.10143905,0.008750412,-0.11136761,0.0734703,0.053917643,-0.0894404,-0.04205164,0.048835874,-0.015754769,0.038327053,0.0015019325,-0.05565764,-0.020295104,-0.028536353,0.0064358246,0.04574296,0.037349027,-0.028604764,-0.036958665,-0.04948623,0.017208032,-0.00915624,0.051393405,-0.018124169,-0.016565604,-0.11073043,0.056708936,-0.03673873,0.0039319955,0.00011606906,0.066197485,-0.020448234,-0.05062258,0.08848904,-0.045161806,0.024776064,-0.066387765,-0.009467005,0.0031355966,-0.095193714,-0.06981745,-0.022278266,0.009082236,0.0421474,0.015284951,-0.033244688,2.5032969e-05,-0.01321719,-0.0027366355,0.07436746,0.006683072,0.012847507,0.037239235,0.03481573,-0.013423542,-0.013965522,0.014769287,0.07527182,-0.019521333,-0.0340947,0.016135003,0.04665822,0.012071251,0.0055257697,0.004473541,0.011022066,0.11282078,0.04287273,-0.000978554,0.019771816,0.104624525,-0.092053875,-0.1505398,-0.05909195,-0.0034435114,0.013003625,0.07918971,0.06479032,0.019996887,-0.07525127,-0.017417634,0.017933283,0.025988627,-0.016587589,0.10347419,0.09000493,-0.011736185,-0.03348241,-0.026906995,0.06956175,0.0016273299,0.06935962,0.09050312,-0.091700844,0.038939208,-0.13496514,2.4427004e-33,0.033585105,-0.0027478833,0.04775173,0.05602038,-0.040124718,-0.028102407,-0.102912836,0.022086201,0.027600927,-0.034026925,-0.0881659,-0.014342607,0.05958924,-0.015611757,-0.038143855,-0.07183971,-0.027146446,0.022751985,0.09938697,0.054699607,0.01144265,0.058299877,-0.08168736,0.054556113,-0.0026445081,0.06124544,0.044972133,-0.0053806514,0.021916568,-0.02529821,0.015217051,-0.09493434,-0.11406298,-0.0064046658,0.020490209,-0.10187676,-0.07238795,0.012748652,-0.004998717,0.029040132,-0.07986285,0.005850875,-0.0007511723,-0.043426275,0.035136223,-0.08079969,-0.015314175,0.052588157,0.027215093,-0.025414819,0.02549232,-0.032443725,0.053498834,-0.013798313,-0.08008665,-0.0226354,0.018073292,0.007332141,0.04495806,0.08556377,0.00059706584,0.089970104,-0.034998488,-0.024757832,-0.047610614,-0.014816064,-0.05825264,-0.057402264,0.019249666,0.07392838,-0.07704369,-0.015840443,0.07727044,-0.0012252791,0.0016317936,-0.06310125,-0.11808181,0.021021506,0.012704305,0.023337416,0.01733107,-0.049658325,0.011342523,0.023325691,0.0013094136,-0.080469675,-0.033558592,-0.04874659,-0.017653529,0.0808325,-0.028879598,-0.050038036,-0.03016472,-0.01744796,0.025228536,-4.5985075e-33,0.094821125,-0.05524653,-0.011318343,-0.043062974,-0.0409469,0.034472305,0.028996052,-0.009072435,-0.017010543,-0.025881287,0.04205214,-0.005808319,0.080256,0.01526543,0.025930356,-0.014480467,0.025174389,0.047588244,0.0027733168,-0.02495879,0.058405723,0.045821957,-0.03269251,0.030371847,0.066970974,0.06339061,0.03749906,0.050551806,0.072943516,0.09087738,-0.050477922,-0.024969611,-0.032381743,-0.09595439,-0.053070694,0.05922758,-0.015300372,-0.04873585,-0.047396418,0.023098322,-0.017627146,0.013413698,0.050627217,0.052475955,0.017637191,0.03966312,-0.07831998,-0.003495278,0.010099244,0.015365094,0.054336313,0.021383442,-0.03194546,-0.032864124,-0.033294328,0.029578919,-0.033737395,0.007977001,0.009682605,0.061827876,-0.039006736,-0.0739916,-0.03154988,-0.027724272,-0.010924388,-0.004219408,-0.01613351,0.01439171,0.017579494,0.02447322,0.04176889,-0.03169584,0.054352596,0.025011465,0.010192281,-0.022037128,-0.017774442,-0.022021167,0.050330665,-0.048880197,-0.0069100927,-0.042083398,0.052866448,-0.05387428,0.029684434,-0.093037196,0.0012085002,0.07250412,-0.0332797,0.017785423,0.046437893,-0.043296617,-0.022639867,0.11499782,0.04459312,-4.527683e-08,0.052759666,-0.12016595,0.03553548,-0.009756318,-0.032794524,0.034964558,0.02249033,0.013695551,0.06346123,-0.057138897,0.045752734,0.035805896,0.011360715,0.029788405,0.06444628,0.015549502,-0.01633089,0.07626832,-0.02635547,-0.004460672,-0.06340503,-0.02998068,-0.16228619,0.030898781,0.033582408,-0.06303459,0.016927391,-0.0046568187,-0.03685009,0.033842366,0.03531327,0.055582747,0.064186566,-0.04845694,-0.048410308,0.027744856,-0.082900815,-0.028831495,-0.06025117,-0.067535244,-0.01230406,0.034805216,-0.12022402,0.05788435,0.09172042,0.014390038,-0.03065902,0.032604303,-0.028331654,-0.014383158,0.040153287,-0.017073017,0.042952515,-0.058970522,-0.047583964,0.058123507,0.019741112,-0.076576784,0.032565404,-0.048406612,0.032318655,0.02851309,0.17742929,-0.023047853 +4.4.1.2,"A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogen sulfide and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase",384,1.0,-0.041771844,-0.04934726,-0.031565797,-0.035626348,0.03195429,0.006914262,0.07127281,0.011561377,0.015318036,0.070497565,0.04122633,-0.017823754,-0.087680385,0.073605485,-0.035960473,0.115593374,-0.074884824,0.013255649,0.020552143,-0.03511031,0.09500325,0.0115563385,-0.04684446,0.041789223,0.012657263,0.113776535,0.053843588,0.014873726,-0.007944422,-0.10280874,-0.06349109,-0.07736754,0.027392762,-0.1013738,0.07558927,0.08897201,-0.08130466,-0.020097675,0.016452033,-0.035431735,0.0654204,-0.017676033,-0.054320913,-0.027668076,-0.033707857,0.00015356814,0.035066642,0.06200862,0.025881473,-0.033522367,-0.05453879,0.0016124503,-0.025609566,0.0203312,0.006510883,-0.014371589,-0.039664183,0.03175288,-0.046764173,-0.025373317,0.045931652,0.038537808,-0.0071548736,-0.027766332,0.09550862,-0.03609631,0.034405828,-0.059263352,-0.008446545,0.019062888,-0.06857482,-0.07658487,-0.015325517,0.006587956,0.033091653,-0.0012670346,-0.051005635,-0.02386891,0.021121731,0.027359365,0.032844916,0.011934489,0.031389046,0.032378793,0.053950135,-0.0010849081,0.016765134,-0.028126903,0.061619103,-0.04427235,-0.055185765,-0.0024427024,0.054350033,0.036623426,0.008902061,0.021371245,-0.014685097,0.05019799,0.017782183,0.015033819,0.010281338,0.08218496,-0.09381051,-0.10638996,-0.06492474,-0.0007799784,-0.0098181935,0.047465574,0.034359477,0.04835767,-0.10950997,-0.007942781,0.015541475,0.031072889,0.034260742,0.12549224,0.07985053,0.01914874,-0.019151373,-0.023873623,0.03091775,-0.001318954,0.026391452,0.10703825,-0.088876724,0.030762015,-0.15408666,2.2972747e-33,0.045294173,0.00825714,0.05858625,0.042048115,-0.052257456,-0.035272706,-0.08195993,0.0192935,-0.022181368,-0.037283957,-0.048432846,-0.019193867,0.07245941,0.023352291,-0.013666749,-0.091791146,-0.040718187,0.09784605,0.10553383,0.047144603,-0.0021413895,0.0717116,-0.06290592,0.042476706,0.013687827,0.06337887,-0.0013341705,3.0041023e-05,0.026967127,-0.009976441,0.06311474,-0.091737166,-0.13523719,-0.014057468,0.019067792,-0.12261331,-0.042348016,-0.007980225,-0.011280745,0.03998565,-0.071572736,-0.028044935,-0.010577604,-0.052031443,0.041659553,-0.11167506,-0.015643675,0.056533307,0.015189349,0.00043926717,0.03216545,-0.041275803,0.07079844,-0.023492677,-0.1012523,-0.036550775,0.024117196,-0.0008986989,0.032239806,0.048051335,0.03187754,0.056543477,-0.062105548,-0.022524372,-0.0703248,-0.039612044,-0.025874587,-0.056072492,0.044491556,0.08336893,-0.06637876,0.028903252,0.022613602,0.017297776,-0.014934952,-0.0852189,-0.07933439,0.010900266,-0.013112149,0.073069535,-0.025427157,-0.05497881,-0.017733555,-0.0057444824,-0.019917576,-0.050395582,-0.038684465,-0.07497936,-0.024450306,0.06344202,-0.017250579,-0.049929503,-0.0708703,0.010013052,0.033221025,-3.7609707e-33,0.11971704,-0.062109623,-0.010681804,-0.035185028,-0.050661687,0.01125038,0.06931613,0.049377475,-0.0042464095,-0.007593052,0.022127556,-0.0051663187,0.08594127,-0.005527125,0.043386493,0.0035547353,0.0057532126,0.0049049477,0.036755867,-0.0033654522,0.05688481,0.042910527,0.009004543,0.034003563,0.036558114,0.06740313,0.018055169,0.04649675,0.03408306,0.04583127,-0.06848574,0.01645654,-0.029696453,-0.06800523,-0.093204856,0.058139622,-0.055945843,-0.06454547,-0.066740826,-0.02079552,-0.00851342,0.06045192,0.029590677,0.0560972,-0.00019978841,0.025861109,-0.04030053,0.035879165,0.027063655,-0.010727742,0.069560304,0.058670625,0.0061060335,-0.0016433358,-0.016991477,-0.0019706485,-0.06033726,0.025511226,-0.0018787998,0.095364444,-0.017712897,-0.066324875,-0.00854856,0.00444724,0.022190973,0.00045632737,-0.012993505,0.017326953,0.025193447,0.034888756,0.07149799,0.003099482,0.028429886,0.02175974,-0.0067167105,-0.012077401,-0.04180576,0.0011641148,0.03729364,-0.06317411,-0.019005762,-0.016523954,0.026725128,-0.073657595,0.021624887,-0.08050955,0.0067731384,0.05803667,-0.02980179,0.04903235,0.03136798,-0.048070185,-0.0233805,0.11291924,0.01320941,-4.6722253e-08,0.058659308,-0.1112483,0.06944145,-0.0022609262,0.004142362,0.0109743625,0.03346721,-0.01728981,0.06832356,-0.05436731,0.012121855,0.02278286,0.006985215,0.051247925,0.053800203,0.044982884,-0.009926659,0.04999237,-0.015354299,-0.06236608,-0.045573168,-0.02607145,-0.16409135,0.06689184,0.051887564,-0.025121909,0.005546256,0.0012888417,-0.011831438,0.019628812,0.026084883,0.03807056,0.047776464,-0.03374828,-0.05512869,0.04868889,-0.08781834,-0.04093608,-0.09175045,-0.065760255,-0.017405614,0.07696084,-0.09435912,-0.0038976613,0.045775883,0.050839607,-0.044107698,0.004146093,-0.03046727,-0.032354847,0.06120262,-0.019897697,0.0014461176,-0.061773043,-0.1164879,0.058166794,0.018223286,-0.07539597,0.009939282,-0.041640192,0.050167322,-0.0027279947,0.18142791,-0.035813186 +4.4.1.4,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +4.4.1.5,Also acts on 3-phosphoglycerol-glutathione.,384,0.99999994,0.01282231,-0.060916472,-0.07583606,0.030910248,0.037177697,-0.00048253252,0.02705221,0.027624868,0.034295157,-0.022057364,0.07370782,0.007415575,-0.031260863,0.08570983,-0.017842958,0.014020575,-0.022795169,0.00069768314,-0.082797915,-0.050060775,0.08814264,0.014014698,0.02250872,0.01554579,-0.0039542103,0.008939483,-0.0052187745,0.007295881,-0.014325418,-0.046279643,-0.043735646,-0.055867366,-0.0022591637,0.021345425,0.004416271,0.041086867,-0.102947146,0.0063919784,0.0029575839,0.061843466,0.09221931,-0.046892174,0.0031524992,-0.065455474,0.04222322,0.008941919,-0.08718678,0.002838844,0.04433968,0.061305624,-0.029689563,-0.036358204,-0.008371993,0.06665701,0.0016536321,0.0046802037,-0.09352987,0.040640213,-0.01917636,0.03597395,-0.042517427,-0.0021004037,-0.0057717506,-0.0111674415,0.017875485,-0.02949636,0.00010369566,-0.052967377,-0.0070513887,0.02199846,0.05134135,-0.042815022,0.047125075,-0.038396496,0.006518718,0.011284057,-0.0375853,-0.04862512,0.0004654512,-0.047586843,0.06338618,-0.004932608,0.017613115,0.10567239,-0.009519951,0.014446525,-0.05575624,-0.07071344,-0.04812949,0.02476061,-0.009794639,-0.0516356,0.004744942,0.00939701,-0.070542574,0.03356211,-0.07988575,-0.00928601,-0.066111706,-0.018389272,-0.029883679,0.03967301,-0.016648548,-0.06427656,-0.056362115,0.056199584,-0.01633506,-0.045176376,-0.021406366,0.010748006,0.009375152,0.010760873,0.03841045,0.033792093,-0.034898918,0.124650024,0.06511471,-0.023517366,-0.11382228,-0.039923053,0.012882639,-0.06834918,0.040097523,-0.038107734,-0.05740201,0.061793398,0.001872056,1.8486144e-33,0.082530506,0.041536782,0.041931424,-0.005332711,0.06655193,0.030365605,-0.0999837,-0.058385197,-0.027943475,-0.061498165,-0.0511696,-0.028851818,-0.00027308962,0.0315679,-0.040808458,0.014694677,-0.019969216,0.043148845,0.08130197,-0.08473285,0.056171753,0.045561988,-0.07074526,-0.03823519,-0.026582299,0.0903378,-0.009726604,0.010331914,0.004545797,-0.012751737,0.040220454,0.0058301543,-0.03923057,-0.011501431,0.036634,0.03682535,-0.08162753,-0.057423867,0.00051732716,0.038431846,-0.004966229,-0.04025996,-0.055968463,0.013609793,0.065695584,-0.013708462,-0.129096,0.056075856,0.06351329,0.10072628,0.019411687,-0.053455036,0.111477464,0.037396878,-0.03929493,0.005111683,-0.0034256636,-0.070086166,0.021769391,0.052388947,-0.011107978,0.085630976,-0.061687436,-0.030944297,-0.011003031,0.029662225,-0.09632699,-0.02212273,-0.07945671,0.05404348,-0.026245117,-0.05433102,0.059079517,0.06520946,-0.013892765,-0.04416365,-0.010570196,0.052165594,-0.06677982,0.03157903,0.01758833,-0.020808326,0.059155352,0.06347271,-0.0982558,0.0051047383,0.003495354,-0.12004277,-0.011832774,0.0024095871,0.056347415,-0.005193461,-0.0041105333,0.016577866,-0.05463789,-2.7608546e-33,0.06799184,-0.068248145,0.08105778,-0.0057190564,0.04006223,0.031237308,-0.0038199117,0.0025469759,0.08419642,0.018906187,0.06207526,-0.02088569,-0.055985678,-0.01670727,0.06673571,0.039250363,0.0036609692,0.08662229,-0.034648255,-0.003335837,0.026055867,0.07420856,-0.01246396,0.12994729,0.08972046,0.0035008162,0.008429074,-0.030371483,0.003494042,0.111574665,0.019872248,0.0007765676,-0.10533124,-0.07359651,0.013381324,0.015926069,-0.03045942,-0.009242888,-0.031336,-0.054078404,-0.01527457,-0.0065546217,0.108043134,0.05348289,0.074750565,0.0903861,-0.013497439,-0.0104504125,-0.115172304,-0.009533834,-0.013846407,-0.0067871804,-0.034953907,0.07064587,0.119185925,0.050755218,-0.031452026,-0.053610843,-0.051319756,-0.03568351,-0.022486549,-0.073862106,-0.038948115,-0.0347788,0.059676785,0.034693286,0.06521775,-0.024707923,0.0846367,0.03164366,0.060889713,-0.020469071,0.034490377,0.053190175,-0.079023704,-0.0197428,-0.109263904,-0.0027542887,-0.015394454,-0.03424202,0.010200201,0.0027652446,0.038120758,-0.063402355,-0.02091845,-0.07168404,-0.031830624,0.12138741,-0.014159596,0.055960957,-0.06289771,0.009460007,-0.047057126,0.0025917527,-0.0060648215,-2.5284134e-08,0.03137858,-0.054781277,0.06417716,-0.07073124,-0.042449504,-0.012470142,0.09725053,0.06772131,0.014223383,-0.05471992,-0.011826258,0.09702893,0.07979365,-0.06643148,0.047098007,-0.0039233225,0.020438168,0.059712823,-0.013710225,-0.020080034,-0.10092088,-0.020515777,-0.052049365,0.0028703297,-0.027143411,-0.01437771,0.04281603,0.08343405,-0.02372649,0.0330442,0.09327994,-0.065251395,-0.009977738,-0.032867096,-0.029258082,0.031062325,-0.017041566,0.002067937,-0.037883777,0.00870227,-0.048676632,0.060606055,-0.0031194156,0.07960557,-0.034715682,-0.030659856,0.014230141,-0.04998783,0.0019851227,0.024126984,0.033952374,-0.006571381,0.015758682,-0.035733376,-0.15770608,-0.042508498,0.014945353,-0.05785491,0.021339983,-0.06571755,0.048705615,-0.028558306,0.17062108,0.116710566 +4.4.1.6,"A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing an alkyl thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Possibly identical, in yeast, with EC 4.4.1.8 cystathionine beta-lyase.",384,0.99999994,-0.06645518,-0.028542757,-0.015033793,-0.04958744,0.042157486,0.017283114,0.03579297,0.021414211,0.028927922,0.09301246,0.03893288,-0.019338777,-0.09305456,0.07456572,-0.05054616,0.06633773,-0.07075376,0.0020028725,0.027203863,-0.046028208,0.09000936,0.046736866,-0.015560079,0.053001244,0.059144966,0.048453104,0.05755242,0.021392694,-0.005691544,-0.12053031,-0.08711978,-0.073700525,0.03010154,-0.100783326,0.061725605,0.10987907,-0.0746826,-0.02436809,0.038483743,-0.022061871,0.06431276,-0.028743945,-0.06520321,-0.018592838,-0.0606321,0.03590721,0.04006366,0.052207228,0.045705616,-0.039764825,-0.052836914,-0.00969438,-0.0014917502,0.002892535,-0.005968303,-0.012019498,-0.026327113,0.031121098,-0.052003384,-0.016979815,0.027479205,0.029106975,-0.019151352,-0.01302534,0.043764085,-0.030661004,0.052318502,-0.031793486,-0.004232809,0.021922318,-0.049720217,-0.08358876,-0.004980704,0.031858366,0.03967299,0.037452217,-0.010139705,-0.053078257,-0.03251627,0.042394686,0.042845223,0.01744322,0.05126876,-0.0037479806,0.04374623,-0.03287805,0.0070725195,0.008550864,0.071927994,-0.021041596,-0.04007877,0.039600838,0.031789135,0.023502933,0.020948203,0.017853256,0.01051349,0.06489618,0.027432244,-0.013530133,0.024563376,0.101973385,-0.07797497,-0.07675316,-0.022471821,0.029599803,0.013474416,0.02913866,0.050511524,0.025112811,-0.06472712,-0.035785586,0.021324944,0.03486107,-0.0090127,0.09425149,0.061698094,0.008544118,-0.051719036,-0.015483368,0.050745707,-0.0013942556,0.03625867,0.10065463,-0.12511988,0.036178,-0.15981337,2.0200419e-33,0.024266595,0.020535002,0.019132027,0.021946985,-0.008635206,-0.03157762,-0.09682405,0.028857125,-0.039708257,-0.057045992,-0.05667945,-0.020148467,0.048290674,0.01287164,-0.030795218,-0.091765195,-0.03138092,0.10224638,0.09554115,0.016789922,0.010012102,0.061001748,-0.06930949,0.03219359,0.030913772,0.06282109,0.011801791,0.036807034,0.019313922,-0.0301521,0.0537,-0.104714096,-0.109083675,-0.0048237587,0.024947809,-0.10807953,-0.02827435,-0.035303175,-0.0040516434,0.03040034,-0.07020211,0.0016622022,-0.00031912723,-0.051710326,-0.00047893918,-0.08243206,-0.02752418,0.037560556,0.008537042,0.016453478,0.042315554,-0.034328222,0.08200798,-0.035165187,-0.098397955,-0.013321473,0.009280272,0.0012175004,0.037141286,0.0618211,0.01755239,0.07618352,-0.041855223,-0.009053412,-0.061484784,-0.04495895,-0.051883575,-0.08528019,0.0013755222,0.09249864,-0.0644686,0.0059966766,0.04298061,-0.01257465,0.0116447015,-0.09283937,-0.1264243,-0.0016254027,-0.06833721,0.063280396,-0.0042664036,-0.072600506,-0.029816959,0.010432391,-0.027783832,-0.037932053,0.00030433174,-0.036801707,-0.0059485887,0.033616666,-0.012624195,-0.078796476,-0.020659767,0.029998934,0.030348705,-3.6777596e-33,0.12694772,-0.0436684,0.034502916,-0.046915375,-0.06477161,0.06394862,0.076752864,0.020681288,-0.043132104,-0.03690781,0.036898658,-0.03295243,0.04974574,-0.0048428294,0.03594051,-0.0061981743,-0.012073544,0.010609262,0.01826875,0.002722854,0.035421845,0.04719929,-0.009126831,0.048552874,0.050873365,0.03953995,0.037713315,0.06823432,0.013880524,0.03658461,-0.07874049,0.03500948,-0.0445209,-0.07425152,-0.07591966,0.0744363,-0.062319443,-0.0743226,-0.051614847,0.011757328,0.03566478,0.08522538,0.018177444,0.058060188,-0.0151289925,0.05592977,-0.019490162,0.026540294,0.034001686,-0.01431435,0.06282176,0.06369931,0.00089120906,0.008389712,0.0025805694,0.0010677826,-0.03236128,0.046331927,0.018931322,0.050026383,-0.009454545,-0.086685516,0.0005000579,-0.006504107,0.029746497,0.0072250604,-0.034721013,-0.0022810576,0.03548923,0.057034213,0.07567464,0.0065741814,0.027195891,0.033844847,-0.0102282185,0.014907947,-0.027050577,-0.05319782,0.014593112,-0.07213392,-0.0011473995,-0.034325406,0.02431571,-0.05642821,0.0026918934,-0.0776499,0.021718204,0.07233058,-0.046522994,0.037762735,0.044358633,-0.049088836,-0.01472553,0.1232743,0.035006467,-4.873319e-08,0.10158979,-0.08693474,0.041638758,-0.023953233,-0.007720506,-0.023567937,0.05242267,-0.0076320125,0.05840584,-0.058270607,-0.01443171,0.01773905,0.037993796,0.05335529,0.06713486,0.044211004,-0.04021706,0.085624166,-0.0035932804,-0.024921292,-0.06483489,-0.011587495,-0.18072689,0.069800705,0.015245886,-0.014973274,0.043528065,0.030379325,0.001328109,-0.0095077185,0.021254899,0.042374063,0.023237996,-0.037664518,-0.05015581,0.038776994,-0.12933406,-0.022387462,-0.080863185,-0.05420643,-0.034392517,0.027464952,-0.08360092,0.010148174,0.0028238785,0.03939948,-0.007601469,0.017643759,-0.0017887516,-0.027808769,0.07373985,-0.0073814234,-0.015259141,-0.07073497,-0.1116938,0.04588024,-0.009978229,-0.06884389,0.0037947125,-0.04724844,0.05282086,-0.04105528,0.17316273,-0.08361581 +4.4.1.8,"A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-homocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds. ",384,1.0,-0.037899517,-0.054307144,-0.026824461,-0.04224808,0.07699108,0.05255925,0.0169926,0.0007912982,0.040553086,0.07367793,0.037526153,0.0035244152,-0.06465485,0.08132143,-0.062874466,0.09172901,-0.072773986,-0.0010559749,0.002671626,-0.039506648,0.10347671,0.004444025,-0.03519466,0.0324247,0.03764058,0.061990768,0.07362688,0.03326689,-0.011950926,-0.070849605,-0.09420467,-0.08742823,0.0040117344,-0.09167435,0.07225424,0.11815399,-0.105981976,-0.0018014932,0.012610806,-0.020394573,0.050888237,-0.03298292,-0.067711204,-0.0037517515,-0.0511108,0.007472965,0.030806253,0.044832144,0.0006192355,-0.031957373,-0.051841695,0.0139776105,0.00601625,0.009936715,-0.0132938,-0.016778542,-0.06672804,0.054861058,-0.043092184,-0.025862938,0.031853165,0.040973686,-0.032306463,-0.037559327,0.04914052,-0.03085669,0.05024805,-0.0345852,-0.0017740821,-0.019194514,-0.06759355,-0.07836453,0.0079500405,0.0057499236,0.041626047,0.040517077,-0.052662265,-0.020143127,-0.025329527,0.011154064,0.055485353,0.007123001,0.024463404,0.025567282,0.06266058,-0.0037526835,0.026026266,0.00836457,0.040655807,-0.030612702,-0.043035496,0.01917523,0.030145245,0.018839639,0.01801374,0.026703175,0.0055858083,0.053127058,0.022234535,-0.035539422,0.023658209,0.11181659,-0.08523687,-0.0902934,-0.0591348,0.0064972225,-0.006865215,0.0776162,0.050241172,-0.0010067432,-0.07629139,0.013519931,0.025454773,0.03147869,0.004268042,0.10803681,0.084804974,0.01062636,-0.041932315,0.016576659,0.04921989,-0.011290949,0.029116223,0.11585364,-0.103647225,0.051387373,-0.16285565,1.8444913e-33,0.04775089,0.010163398,0.020856196,0.039449416,-0.029505668,-0.033743415,-0.09354426,0.03172134,-0.006729513,-0.040404864,-0.055829734,-0.034436535,0.06414697,-0.009903552,-0.051516376,-0.077733025,-0.033768393,0.045271624,0.10488111,0.03912225,0.020978935,0.0785339,-0.062648706,0.047388922,-0.008704389,0.07291678,0.02213807,0.03195673,0.011677479,-0.03118613,0.052330516,-0.11536249,-0.11997673,-0.02436264,0.03313804,-0.08526389,-0.06498071,-0.008818857,0.011302979,0.043635633,-0.07764848,-0.021189684,0.00583526,-0.040677994,0.01968692,-0.093475014,-0.013595138,0.061748356,-0.0026810975,-0.007549889,0.06837045,-0.038022373,0.055478215,-0.034015834,-0.11258873,-0.026963657,0.024603149,-0.009137257,0.03146571,0.07370641,0.039534435,0.06457938,-0.05377538,-5.8061796e-05,-0.045572434,-0.04469464,-0.050194327,-0.07347656,-0.004077184,0.09532668,-0.08193496,0.01458771,0.055625945,0.0040409854,0.010936196,-0.06280331,-0.13907085,0.010359231,-0.0009361835,0.046187297,-0.022226453,-0.065260634,0.0012033836,0.01036352,-0.048198868,-0.0651882,-0.040478382,-0.06521798,0.0024928255,0.049102645,-0.008712005,-0.07892369,-0.02952478,0.0156195415,0.03897601,-3.863739e-33,0.11412123,-0.050679397,0.0238373,-0.054786634,-0.035775617,0.05227971,0.05120665,0.010814077,8.1080645e-05,-0.025486303,0.031180883,-0.02679084,0.05187582,0.021605514,0.024650233,0.012558499,0.0070782863,0.019028505,0.015917424,-0.004737133,0.008380025,0.056755356,0.009703908,0.03999314,0.0616284,0.06095177,0.041382935,0.052274264,0.015192554,0.06554259,-0.051053494,0.019193374,-0.03425217,-0.05983141,-0.08043093,0.06929464,-0.0799094,-0.06441485,-0.037805058,0.00648882,0.007186751,0.05202622,0.045421742,0.050155926,0.008762195,0.0393633,-0.049217492,0.018398926,0.009979563,-0.018549426,0.054508347,0.06669268,0.013977745,-0.019650772,0.007918998,0.027546933,-0.041393973,0.00082591065,0.019783137,0.06921342,-0.012725711,-0.081210814,-0.010561962,0.0044650445,0.011054101,-0.011791981,-0.017071987,0.011512155,0.034433573,0.050199404,0.06512437,-0.019299377,0.028150203,0.057042643,-0.02854809,-0.006086326,-0.02239897,-0.012447315,0.042098355,-0.06943453,-0.0017441405,-0.037358448,0.015706629,-0.092952006,-0.0026886773,-0.08640371,0.019688189,0.06432983,-0.01906782,0.014070795,0.03271655,-0.033399258,-0.019941313,0.099241845,0.06173859,-4.5617703e-08,0.06948718,-0.11379569,0.04789906,-0.026185205,-0.014867248,-0.015930418,0.055916626,0.018315425,0.068973996,-0.051885977,0.0059024426,0.0027998898,0.028197428,0.019060241,0.037873033,0.04368478,-0.0007960665,0.08598824,-0.0064376756,-0.042712104,-0.07374192,-0.03997742,-0.17664891,0.04895867,0.038617566,-0.058168046,0.03214553,0.04153815,-0.011350933,0.0137442695,0.02738304,0.023089243,0.049301032,-0.068468556,-0.055134013,0.064950995,-0.09425539,-0.03548232,-0.05613561,-0.052852023,-0.019350994,0.031183748,-0.08715238,0.011085169,0.047547955,0.040827204,-0.028410682,0.0036936477,-0.009264402,-0.008081229,0.052729167,-0.031199226,0.00018915137,-0.076651834,-0.082388446,0.056957465,0.015836794,-0.074787185,0.036043487,-0.078101546,0.015433162,0.01955788,0.1800945,-0.0602729 +5.6.1.1,"A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.",384,0.99999994,-0.045117043,-0.036642194,-0.01375163,-0.09716187,-0.0153895365,0.061992824,-0.036176126,0.04587133,0.010968362,0.027960693,0.034952316,0.005868511,0.05483736,0.05005621,-0.037537497,-0.045121573,-0.09832051,0.06562787,-0.037464857,-0.08601252,0.039981592,0.027979033,0.051612195,0.021101601,0.03201321,0.009219207,-0.019750826,0.022452205,-0.0030964438,-0.018154457,-0.10776111,0.022209372,-0.03705224,-0.04519231,0.12476633,-0.011675242,-0.046130974,0.00073260535,0.02856925,-0.050415196,0.19003084,-0.043136705,0.062599935,-0.001550007,-0.012405091,0.054294128,0.06978992,0.01976471,0.09465255,0.030518724,-0.033229332,-0.09044027,-0.020994525,0.027395701,0.025074305,0.06578945,-0.040005557,0.0583063,0.07795854,0.024099141,0.004876217,-0.03212975,0.04418046,0.015462576,0.06458792,-0.08541548,-0.013724499,0.027284928,-0.017960418,-0.008182822,0.01739184,-0.066779785,-0.06481677,0.016967682,-0.02429447,0.006600509,-0.061880745,0.010097844,-0.05886928,0.10182117,-0.016946068,0.011639392,0.06539821,0.012568707,-0.0036752736,0.016700143,0.08741405,0.012948315,0.023503523,-0.027348906,-0.09864037,0.0037899716,-0.014678554,-0.06358658,-0.05109858,-0.043084435,-0.019059746,0.041238423,-0.026775949,-0.0028881568,0.12206499,0.009026769,0.061256565,-0.017316394,0.021616217,-0.020097269,-0.03158626,0.025908606,0.028327411,0.03892164,0.03343606,-0.033738222,0.062196102,0.014038273,-0.033654675,-0.024861591,0.076451324,0.009569884,0.039543588,-0.03642747,-0.021678852,-0.022366093,0.009109038,0.02683025,-0.07860214,0.06202139,-0.12223666,-1.5343652e-33,-0.03724424,-0.06090666,0.042656958,0.000763828,-0.015807541,-0.006267975,-0.06429859,-0.0047375807,0.015698873,-0.035696976,-0.102859214,-0.016761713,0.0900869,-0.033285614,-0.057949416,-0.05510925,-0.013636786,-0.024585458,0.038793992,-0.030082986,-0.02104023,0.11146302,0.027129594,-0.0038917372,0.01116816,-0.060158152,-0.06978434,-0.032177716,0.040904142,-0.03221166,0.0013246506,-0.024812577,-0.11910523,-0.033373117,0.01970759,0.004523927,-0.04527664,-0.010424615,0.009085515,-0.020545408,-0.11075098,0.008232623,-0.04303662,-0.02981341,-0.0028363154,0.00325083,-0.02949887,0.023720715,0.02593295,-0.012650208,0.055250444,-0.041583985,0.06386678,-0.012630539,-0.07772265,0.046014268,-0.044020083,0.017543396,-0.020600112,0.049107313,-0.0200017,0.030981995,-0.028464677,0.043328945,0.00032386425,0.071297884,-0.055175062,0.007207889,0.060413215,0.015746472,-0.05716537,0.037261542,0.0742511,-0.00966283,0.069413565,-0.022592817,-0.0046176026,-0.050804175,-0.07225571,-0.018602913,0.043996863,-0.025436016,0.03329529,0.0029390515,-0.04124609,-0.011353878,0.012676363,0.027628453,-0.031136025,0.017715216,0.12681793,-0.007679643,0.0012921275,0.09976185,-0.041739047,-1.4662914e-34,0.028332323,-0.06814127,0.06842824,-0.052593794,-0.01423037,-0.036712997,0.049674783,-0.048538126,-0.032704018,-0.018089142,-0.007833191,0.054367125,-0.06459154,-0.04119965,-0.017044785,-0.016486181,-0.01764471,-0.008414683,0.072109245,0.013310645,0.016751172,0.030520832,-0.01046235,0.060167678,-0.06500637,0.01783672,0.025568891,-0.033530954,0.09267223,0.04029456,-0.0634049,0.051031336,-0.002814795,0.007190924,-0.066060275,-0.03627424,0.02154527,-0.019277602,-0.029943489,-0.015616996,0.044523496,0.05298932,-0.071936004,0.10170962,0.061826374,0.061398022,0.035503224,0.08288721,-0.16876382,0.0011701161,-0.040729165,-0.0058856267,-0.001492952,-0.006307341,0.028638363,0.025525521,0.06856821,0.039968796,0.0069171726,0.0016162207,-0.0033285283,-0.102167055,-0.03171923,0.020297894,0.011814434,0.08684311,-0.0048685516,0.03555013,-0.07322365,0.10615143,0.05444018,0.07213027,0.014752391,-0.03282968,0.052511778,0.04090657,0.0062505533,-0.013720833,0.015997795,-0.014962911,-0.065281615,0.086351655,-0.04183801,-0.060131915,0.061203245,-0.029656189,0.010685791,0.11019177,-0.00048081987,0.040799867,0.07330558,-0.052694626,-0.03474286,0.082621135,0.013511505,-2.1099847e-08,0.07115514,0.016324563,-0.0015135014,-0.018100701,-0.018514207,-0.009496964,0.018614242,0.118846335,0.09296413,0.007967431,-0.0035126775,0.015861157,-0.011681241,-0.026986836,0.078416415,0.092863575,0.0054522683,0.011018669,-0.049642894,-0.0272776,-0.09195643,-0.013236697,-0.08754097,0.044127326,-0.04084736,-0.065912925,-0.029804101,0.13464607,-0.12589556,-0.09179762,-0.00256176,0.011041438,-0.052184757,-0.048906315,-0.098115176,0.005011191,-0.0124357855,0.0010170026,0.055137582,-0.07409161,-0.06872367,-0.09861654,0.040909532,-0.050027415,-0.006196802,0.05199152,0.070774995,0.029566018,0.013201527,0.005902532,0.009498028,0.03994975,0.042389777,-0.078245215,-0.09287842,-0.027685506,-0.017344855,-0.020170286,-0.05842107,-0.046722043,-0.0069271824,-0.005393926,0.12633938,-0.07872144 +4.4.1.9,Contains pyridoxal phospate.,384,0.99999994,0.012800393,-0.031037938,-0.069393136,-0.007850169,0.0723104,-0.0022560032,0.03842862,0.05500981,0.051426187,-0.014483404,0.08319714,0.009008256,-0.090264544,0.067103624,-0.018488312,0.0044019255,-0.029190341,0.017394252,0.016598614,-0.017131943,0.06514542,0.058684897,0.054346364,0.066443264,-0.08493747,0.07748878,0.019244013,0.062227733,0.0024043203,-0.06491653,0.0069508567,0.08880983,0.008271409,-0.10305394,0.074612536,0.04225896,-0.114543214,0.0074824886,0.033438377,0.017717022,0.046692386,-0.078132965,0.02024423,0.02020273,-0.024379205,0.020493835,0.013853806,0.022867778,0.08958312,0.015682375,-0.102124214,-0.050775107,-0.040369596,0.033455595,-0.02879175,0.013372488,-0.039674595,-0.0043916395,-0.02023212,-0.022306927,-0.02463963,-0.01145132,-0.04958945,0.035622593,0.002475374,0.04541038,0.0036740662,-0.09918144,0.023715887,-0.040336847,-0.006444414,-0.02801956,0.09154612,0.04491065,-0.0529422,0.105720125,0.05546276,-0.07534561,-0.0111758225,0.00968673,-0.007835199,0.01477136,0.008489637,0.024539078,0.06281519,0.070731245,-0.0011999103,-0.037307136,-0.07542329,-0.051049072,0.025986351,-0.007970395,-0.020251531,0.003280241,-0.026508475,0.048188154,0.017994262,-0.0048076985,-0.013974378,-0.029627819,-0.036372356,0.0029552989,-0.025441268,-0.05963706,-0.11699878,0.0018057721,-0.011774529,-0.0187264,0.025288267,0.029604051,-0.07087956,0.05398228,-0.005797262,0.005350032,0.014155698,0.021038422,0.0846066,-0.0103160925,-0.06848833,0.013102488,0.015541032,-0.063028485,0.058529813,0.020381443,-0.052291643,-0.08026957,-0.018613597,2.755691e-33,-0.002488401,0.056136437,0.019431803,-0.00066953496,0.02447777,0.029965207,-0.052018426,-0.09639756,-0.01606268,-0.02643886,-0.12492066,0.0019173237,-0.039350644,0.056135114,-0.07622228,-0.035998523,-0.050067853,0.056572564,0.098724164,-0.065414794,0.023308845,0.06388541,-0.035137035,0.039631445,-0.040750764,0.09371856,-0.024244206,-0.007032728,0.0067084203,-0.004868214,0.10283149,-0.049070694,-0.08371141,-0.010647663,-0.0465301,0.056002572,-0.09758429,-0.06793621,-0.058687724,0.048373207,-0.021411855,-0.019948967,0.013835067,0.07376329,0.019790092,-0.13041979,-0.115310356,0.055126082,0.021226611,0.028860694,0.021232868,0.0053562266,0.04448109,-0.0015658926,-0.07286277,-0.04082509,-0.029302241,-0.034088414,0.027867453,0.059237387,0.047496308,0.102685556,-0.07386637,0.0047632796,-0.024987603,-0.019584063,-0.023387352,-0.061787322,0.0001741154,0.01749644,-0.0058057485,0.014737585,0.09958799,0.059732776,0.012420183,-0.026998393,-0.03885155,0.033167854,-0.0034297411,0.036917817,-0.05169545,-0.12058196,0.020699175,0.07776594,-0.02418439,0.006454306,-0.00967274,-0.02428459,0.024292316,-0.01977814,-0.0017478369,-0.11373624,-0.050918713,-0.011085104,0.0019595565,-2.6502527e-33,0.06787017,-0.056092754,0.08128159,-0.0029324798,0.014792738,0.033580273,0.07328495,0.027321368,0.059932675,-0.037367657,0.04566642,-0.021100203,-0.020364989,-0.07944097,-0.008566918,0.06953214,0.036426894,0.08185936,0.054310787,0.013044599,-0.04740191,0.049338013,-0.0055982997,0.0736847,0.08081037,0.08970958,0.01315624,-0.024160033,-0.07111585,0.04422513,0.031112507,0.019736951,-0.07475116,-0.04470968,-0.07538156,-0.0044485605,-0.1048198,-0.039142642,-0.040958114,-0.012117707,0.0035979724,-0.027879331,0.051134337,0.07403203,-0.00024066724,0.019942904,0.00227247,-0.014365092,0.05182131,0.045882203,0.029355241,0.10775998,-0.06205964,0.0022254544,0.14081047,0.05869688,-0.04831196,-0.03847844,-0.03083359,-0.027711228,0.013709202,-0.00091972464,-0.0544009,0.013344637,0.11422871,0.061325517,0.0020999364,-0.0029736261,0.050235197,0.06448189,0.098375686,0.07036458,0.013670932,0.032858886,-0.055718012,0.0115768295,-0.019547261,0.03449592,0.02978624,0.0066898344,-0.010538716,-0.043343503,0.00816317,-0.049738,0.04161472,-0.039105184,0.003497011,-0.033063155,0.0015217387,-0.003412059,0.035027344,-0.00062995957,0.0139155965,-0.00096277636,0.101600595,-2.1281986e-08,0.09123585,-0.04977956,-0.0075570988,-0.09742992,0.010090308,-0.02120538,0.08291395,0.0046340586,-0.0069038635,-0.014224257,-0.0006127718,0.03190067,0.050764505,0.0045046136,0.05249503,0.023984639,0.008761216,0.07506852,-0.018502163,-0.048726764,-0.09637472,-0.002092266,-0.07355581,-0.0071928175,0.025388196,0.0103124725,0.04610535,-0.03680057,-0.0078071016,0.065568805,0.06975785,-0.044498388,-0.0060003595,-0.05804974,-0.00319103,0.054270465,0.011680305,-0.018570704,-0.110316575,-0.0048699323,-0.08892543,-0.041150637,0.035824265,-0.002830433,-0.004602341,-0.037033115,-0.05511773,-0.024644662,-0.018218245,-0.027429763,0.055028696,-0.009979618,-0.026671795,-0.053774357,-0.14866376,0.028984403,0.06282507,-0.053838845,-0.0070292978,-0.09210548,0.031257074,-0.024131631,0.19359593,0.0064767846 +4.4.1.10,"A pyridoxal-phosphate protein. Can use a second molecule of cysteine (producing lanthionine), or other alkyl thiols, as a replacing agent.",384,0.99999994,-0.04300045,-0.069672585,-0.021436436,-0.06267088,0.029764226,0.041520525,-0.0064886175,0.05653007,0.041447733,0.02821237,0.046840884,0.027417645,-0.064116135,0.07564334,0.0027662432,0.06600082,-0.017519973,0.089581564,0.027253343,-0.03093176,0.048343163,0.06257426,-0.004045793,0.02865457,-0.0085067125,0.05462561,0.014881905,0.0854309,-0.0059170495,-0.0416591,-0.033170078,0.008852964,-0.02839577,-0.044591635,-0.004142091,0.11481924,-0.14124973,0.03305163,0.007649139,-0.04845248,0.11010045,-0.09976792,-0.03320889,0.0138809355,-0.034227375,0.013282265,0.0050270557,0.06932428,0.03705399,0.039375115,-0.058509156,-0.025020368,-0.024190515,0.03359655,-0.019542625,0.00045765378,-0.033802252,0.048477262,-0.033086207,-0.07625237,0.03410354,0.006706558,0.012693,0.016942255,0.05410083,-0.049154606,-0.005999947,-0.006258293,0.009828155,0.0128626535,0.021584949,-0.011269197,0.040014435,0.064170524,-0.015959717,0.07286253,-0.06263853,-0.07897822,0.0027463937,0.0038327875,0.019974604,0.03205807,0.031768717,0.09299297,0.123396486,-0.002166861,-0.022165887,0.014309655,-0.08356758,-0.06483313,0.013512362,0.0723067,0.029384024,-0.031412497,-0.054139867,0.038836572,-0.0029501256,-0.017347317,0.0057678595,-0.012299014,-0.019372702,0.010947545,-0.035434548,-0.10809064,-0.075662464,-0.011870856,-0.04697066,-0.009349222,-7.863997e-05,-0.025663583,-0.061524462,0.009615792,-0.0144743,-0.015992353,0.0105534475,0.07829868,0.04038654,0.012903638,-0.064458095,0.046030607,0.004140079,-0.03979266,-0.02122439,0.0729345,-0.052635368,0.013900202,-0.073354214,6.2381097e-34,0.056642324,0.09321209,0.021327376,0.044081535,0.045630552,-0.0018512446,-0.032620072,-0.025621599,-0.027736258,-0.08351291,0.03751451,-0.030637546,0.060735863,-0.03992712,-0.014531133,-0.08276303,-0.08363063,0.042889807,0.1593762,-0.047897168,0.004546739,0.095393,-0.03083602,0.07880816,-0.012414358,0.06078601,0.024103912,0.0054758596,-0.0068987664,-0.0010754622,-0.00033054766,-0.0030467845,-0.0939308,-0.037985753,-0.028548384,-0.100345686,-0.064660944,-0.0878762,-0.012271311,0.0059109908,-0.026577525,-0.028786648,0.006893345,-0.019933036,0.003948718,-0.13267484,-0.075121574,0.056636572,-0.044261917,-0.0034342492,0.09202275,-0.059924893,0.046953008,-0.0534654,-0.09575964,-0.03280722,-0.06559807,-0.063602954,0.008820898,0.034401193,0.08735146,0.027622603,-0.050922696,0.068427324,-0.028216938,-0.05775634,-0.019351544,-0.084103994,-0.03982827,0.0848878,0.042002458,-0.04692762,0.03912798,0.027455572,-0.029291144,-0.023605842,-0.06975125,0.028082868,-0.004683714,0.047082957,-0.030850807,-0.06315842,-0.04569884,0.0033725023,-0.011101658,-0.037927225,0.017259741,-0.04888909,0.012476345,-0.0052190474,0.03600414,-0.113297455,-0.08886948,0.047317192,-0.012907199,-2.3783724e-33,0.042044416,-0.062417287,0.07279847,0.018657014,-0.015715104,0.020325793,0.072459824,-0.086254075,0.08103924,-0.013683526,0.051127084,-0.067671075,0.022730026,-0.026473368,-0.01471643,0.043423746,-0.037747428,-0.031382192,0.0192727,0.032218482,-0.005461119,0.03233546,0.014380762,0.087530956,0.07488974,0.054152198,-0.02562195,0.05978048,-0.0006285846,0.059354525,-0.059119545,0.00308982,0.009242385,-0.05573497,-0.011785244,0.07381838,-0.030978449,-0.04830588,-0.004177897,0.014330613,0.055808537,0.0144555755,0.078517325,0.07526975,0.016020281,0.037163284,0.009628056,0.01946045,-0.0035588387,-0.082238436,0.09566684,0.05615591,-0.051747203,-0.0010745915,-0.01209871,0.079303116,-0.048237555,-0.044525344,0.019055685,-0.036868043,-0.037901584,-0.09414226,-0.02129051,0.04622659,0.025466757,0.054355953,-0.038829032,0.003698125,0.036469065,0.043492775,0.11877524,0.070971645,0.04892272,0.06411668,-0.02412888,-0.0178551,-0.05605155,0.047865193,-0.0109402,-0.013447994,-0.010352108,-0.012858171,0.009103264,-0.06813628,0.034867894,-0.02835223,0.07034862,0.095134795,-0.03863471,-0.030171225,-0.021244723,0.0017325594,-0.029759662,0.10534964,0.06959318,-3.5103323e-08,0.04674871,-0.1025588,0.02947732,-0.079624444,-0.013836413,-0.06509212,0.051896468,0.020273332,0.06757232,-0.040310785,-0.035386458,0.068929866,0.061119676,0.0076807523,0.08350685,0.039335046,0.0025831026,0.02869538,-0.017151712,-0.09013586,-0.058341574,0.01763759,-0.0491727,0.024936832,0.0030738155,0.02804341,0.0018805484,-0.0512851,-0.02833408,-0.01358753,0.06596836,-0.03463756,-0.011013179,0.0025924693,-0.016053088,0.10311846,-0.08086158,-0.049079265,-0.029110836,-0.016553873,-0.09654242,0.03608461,-0.115942776,0.015286964,0.017418394,-0.045841023,-0.030160926,0.0039114333,-0.024961272,-0.015870092,0.034783326,0.0028989713,-0.029629895,-0.08473257,-0.08055739,0.033097297,0.055919476,-0.031109108,-0.04252302,-0.07733747,0.0019569856,-0.00956843,0.17823036,-0.035323285 +4.4.1.11,"A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing methanethiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme is involved in L-methionine catabolism.",384,1.0,-0.022161264,-0.06387669,-0.02915622,-0.018033398,0.06253374,0.02960826,0.027470374,0.044060647,0.022370989,0.05583327,0.032629453,-0.042241476,-0.06527386,0.07272587,-0.03738684,0.109929174,-0.101940535,-0.018074812,0.008982924,-0.024314366,0.103293315,0.038012356,-0.028691536,0.022705406,0.037179124,0.07325349,0.044368338,0.013595505,0.005380147,-0.0853527,-0.041029364,-0.067615755,0.0327515,-0.08067452,0.07393234,0.10094087,-0.07899976,-0.0071161697,0.037618216,-0.008928125,0.06671717,-0.03817678,-0.013212527,-0.05765444,-0.02422456,0.004737701,0.0151843,0.0546833,0.003538126,-0.049045097,-0.064082205,-0.006799421,-0.0323861,0.029163653,-0.008904066,-0.012307943,-0.021128695,0.020259848,-0.060343213,-0.04620467,0.060233984,0.019819641,-0.005716934,-0.024626832,0.09113032,-0.052535214,0.040203825,-0.07296626,0.040195845,0.014184653,-0.07302393,-0.06512785,-0.0030557464,-0.011668606,0.009934284,-0.0071816538,-0.027576905,-0.0012304821,0.0326604,0.0012591871,0.054792207,0.008908465,0.03535353,0.021792542,0.051192604,0.016083876,0.0006042372,-0.038803317,0.07681702,-0.055736996,-0.0726088,-0.0108053,0.036469646,0.013691221,-0.024636691,-0.005580761,0.027773554,0.064431176,-0.008315455,0.021584252,0.006430962,0.08287971,-0.11987841,-0.09174351,-0.10803956,-0.0033790842,0.0058910805,0.043257695,0.03854718,0.012768795,-0.06097088,-0.011301416,0.03581173,0.0421007,0.021543153,0.11525319,0.094600335,-0.01205354,-0.017136328,-0.005158483,0.018520549,-0.014746251,0.055465996,0.09111544,-0.082155205,0.021224989,-0.13121621,2.8340724e-33,0.05885887,0.014532141,0.02929866,0.024514433,0.0042009605,-0.039426096,-0.095081925,-0.00055334665,-0.052402634,-0.04677812,-0.043682206,-0.012710824,0.06883009,0.008334341,-0.03474175,-0.07300883,-0.059553087,0.071843624,0.07767037,0.03544849,0.002928984,0.058165602,-0.05151417,0.06497015,-0.007585218,0.060749624,-0.0017942231,0.011652634,0.012179572,-0.008066104,0.041694637,-0.056152947,-0.14657544,0.004022734,0.008402401,-0.085789226,-0.08447006,-0.018508764,-8.367438e-05,0.040213052,-0.04821638,-0.014681969,-0.019907339,-0.041658323,0.02173654,-0.08317132,-0.016498867,0.0896891,0.021177514,0.0049186912,0.05255523,-0.047252905,0.056311805,-0.042653497,-0.12723055,-0.027839309,0.0123043945,-0.034545563,0.038112167,0.08269643,0.03654489,0.03879035,-0.04223415,0.026860839,-0.06357027,-0.057970207,-0.0065045496,-0.059488162,0.08196753,0.092855945,-0.045849074,0.024826556,0.04949482,0.042437237,0.0006755097,-0.085337035,-0.080966294,0.023440685,-0.012763724,0.08056515,0.029929982,-0.06482957,-0.004423247,-0.025150308,-0.032232583,-0.046705157,-0.031761847,-0.10734206,-0.019955471,0.083414815,-0.035813868,-0.065265045,-0.04027871,0.001906798,0.044309564,-3.29707e-33,0.11266864,-0.051036265,-0.0064747687,-0.053428438,-0.052653983,0.017559059,0.06224991,0.024307262,0.009786281,-0.022299973,0.057875577,-0.015034635,0.06925905,0.0116836615,0.06256855,-0.0025540076,0.018173778,-0.0064103366,0.05131218,-0.0022530442,0.07789278,0.024678089,-0.039659224,0.03316685,0.057876177,0.063457675,0.009562784,0.04694537,0.028758211,0.020575415,-0.054965824,0.019781608,-0.029805811,-0.0755921,-0.09708397,0.06490083,-0.07336047,-0.054019462,-0.029692665,-0.028853834,0.0030869422,0.07479574,0.021067286,0.039377414,-0.002142367,0.02532566,-0.056544565,-0.015367415,-0.002046425,-0.02935272,0.0677146,0.020628475,0.0016287282,-0.009826414,-0.020210471,0.053149164,-0.064271614,0.029630315,-0.0076601375,0.06796755,-0.0015382965,-0.06652006,-0.015848238,0.035889603,0.03157035,0.0064223357,0.0020525274,0.019173916,0.031163735,0.034566674,0.0775947,0.01159537,0.05551878,0.0557601,-0.033373967,-0.022398336,-0.042225644,-0.0018952622,0.027327273,-0.09145215,-0.014333613,-0.03380003,0.0368834,-0.07940698,0.009678684,-0.089901015,0.015357312,0.079490595,-0.0082540745,0.06698236,0.0065102316,-0.040371258,-0.015039336,0.09008423,0.052012965,-4.7748575e-08,0.072432786,-0.14172639,0.0319432,0.015565958,0.0043777,0.01815023,0.03995375,-0.026672645,0.055508602,-0.061368242,0.0148450965,0.032523904,0.019820662,0.032055,0.0318185,0.06340771,-0.0014248751,0.050822984,-0.02452392,-0.04450831,-0.060383346,-0.008013617,-0.14452827,0.03583061,0.050060634,-0.010034804,-0.0025951297,0.05724731,-0.013788181,-0.0015162631,0.015760303,0.022395888,0.053010732,-0.042151906,-0.06616088,0.03927342,-0.08864957,-0.06280871,-0.07067142,-0.059354704,0.011849497,0.09424227,-0.06256119,0.0137419915,0.030142698,0.03274862,-0.07084937,-0.019926222,-0.005130516,-0.004666702,0.060333718,-0.0019065641,0.009754258,-0.05050349,-0.12928085,0.05178782,0.016138617,-0.053014677,-0.002441639,-0.05402203,0.026912069,0.0076589547,0.19782022,-0.05221209 +4.4.1.13,"A pyridoxal-phosphate protein. The enzyme is promiscuous regarding the moiety conjugated to L-cysteine, and can accept both aliphatic and aromatic substitutions. The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. While bacteria and plants have dedicated enzymes, all of the animal enzymes discovered thus far are bifunctional, most of which also act as aminotransferases.",384,1.0,-0.03877955,-0.056603428,-0.052966304,-0.0758506,0.034958825,0.06723231,0.0075880103,0.029954232,0.07629372,0.0761194,0.04038376,0.011318412,-0.08680581,0.10090539,-0.056482874,0.06824459,-0.10435371,-0.016432328,0.04690401,-0.04759461,0.056983624,0.051438753,-0.05604,0.019265436,0.025445065,0.051839504,0.049209546,-0.015866943,-0.026753383,-0.037462316,-0.07715589,-0.02596454,0.023837155,-0.056112166,0.04557952,0.13750666,-0.08822397,-0.02648784,0.060906794,-0.045246586,0.06081591,-0.020607166,-0.055322785,-0.037218373,-0.077728495,0.012814787,0.06304482,0.02008505,0.035715107,-0.030863639,-0.05759259,-0.012216432,-0.049492806,-0.00017546082,-0.025663283,-0.009326116,-0.020853227,0.013977181,-0.05980937,-0.039897565,0.019652087,-0.014061084,0.0105187455,-0.0041705864,0.04911539,-0.046859834,0.0011991002,-0.051179245,-0.0015998306,-0.049603656,-0.06380701,-0.07443549,0.0288463,0.0053490857,-0.015496308,0.016932694,-0.041300483,0.01869136,-0.01107952,-0.02221916,0.024415279,0.0027299845,-0.0064474074,0.024148574,0.0997473,0.0061760694,-0.008171808,0.03621519,0.004695914,-0.04537062,0.012102736,0.009831919,0.04416107,-0.029901324,-0.027265437,0.04127165,0.02867286,-0.009724529,0.039330263,-0.05543108,0.004234453,0.08188333,-0.036194157,-0.10132092,-0.08679405,0.03303751,-0.030916754,0.0726408,0.045790896,-0.024418566,-0.08940397,0.041345906,0.047016907,0.035731122,0.020223338,0.096617326,0.06772246,-0.01266196,-0.036678743,0.019032897,-0.006716249,-0.0083081415,0.058092743,0.1243105,-0.044507336,0.054664295,-0.116219476,2.1367082e-33,0.08454846,0.022786807,0.011231469,0.015770247,-0.02428632,-0.007599745,-0.061089166,0.01205352,-0.029758524,-0.019539906,-0.056831013,-0.05772677,0.066416845,0.012835251,-0.0246262,-0.038940128,-0.06694529,0.050020266,0.12106261,0.050774354,0.01426504,0.072649494,-0.020918159,0.07137029,-0.011986127,0.054204904,0.025749672,0.03368515,-0.0024115492,-0.032311164,0.058779825,-0.11740688,-0.13233745,-0.029129768,0.054052424,-0.070460424,-0.04766451,-0.016674068,0.0061513763,0.028082026,-0.06710416,-0.055271078,-0.0050020497,-0.017474048,0.03369483,-0.07980255,-0.04494862,0.061125576,-0.008657655,0.009198389,0.048627835,-0.0547616,0.0881758,-0.055440683,-0.10847761,0.0110601,0.024890589,-0.015079778,0.004296152,0.08669939,0.06635656,0.030630227,-0.09225852,0.005253093,-0.042444106,-0.04144924,-0.025220696,-0.06890095,0.04992977,0.13564998,-0.05486476,0.012879296,0.046522975,0.018826853,0.011600984,-0.06993212,-0.1065783,0.009998224,0.031881128,0.06917554,-0.015462371,-0.038117927,-0.012425295,-0.008085467,-0.042478487,-0.06547586,-0.00779945,-0.11075534,0.0016396994,0.024962282,-0.011689728,-0.064673565,-0.05182514,0.02466575,0.049670313,-3.391355e-33,0.11392844,-0.08417314,0.018148258,-0.019048551,-0.061378982,0.034014236,0.058868274,-0.000637991,0.010036703,-0.011917951,0.046776976,-0.008566713,0.015560877,-0.012489022,0.030728435,0.009900632,-0.0046522273,0.0003574394,0.034687545,-0.017788619,-0.038446914,0.06811543,-0.0036419416,0.010027364,0.04960044,0.07035145,-0.0421588,0.06893332,0.021668067,0.04034263,-0.032149713,0.044619758,-0.041041873,-0.054853134,-0.050760362,0.044436984,-0.07706264,-0.03922309,0.005062799,0.0057279337,0.03905108,0.07973022,0.033784717,0.0405053,0.006802725,0.033210557,-0.06786789,0.0064739212,-0.031417888,-0.020516071,0.06301849,0.05433041,0.02162538,-0.020261794,0.058631886,0.026455447,-0.04042886,0.011605373,0.006342589,0.03408656,-0.010380433,-0.113806866,0.034791846,0.06560566,-0.016222969,0.0168508,-0.019592823,0.00017209075,0.03923461,0.05142311,0.052356243,-0.0025200876,0.031831034,0.08362901,-0.019686526,-0.0015402022,-0.028790941,-0.005545432,0.025548771,-0.05624016,-0.006768979,-0.034880154,-0.013888655,-0.10527725,0.010503385,-0.09247655,0.010264574,0.08467414,-0.0033432795,-0.003848015,0.002734138,-0.0375113,-0.0035750517,0.061431203,0.08882106,-4.7104713e-08,0.025808176,-0.086982064,0.023557609,-0.03610754,0.012359468,-0.002293752,0.028061343,-0.015541051,0.05873802,-0.0560175,0.0040013334,-0.0033985744,-0.0073164804,0.043805476,0.038915172,0.068044245,-0.012876127,0.043186042,0.0009773592,-0.016948182,-0.07216052,0.005089608,-0.19449191,0.043078404,0.061992154,-0.03206426,-0.024688333,0.042204402,-0.0025563932,0.015597729,0.032319073,0.015374482,0.061741184,-0.05819023,-0.032239486,0.04510452,-0.055783067,-0.038560987,-0.027957743,0.0041817343,-0.0011095677,0.024255572,-0.10516113,-0.021746054,0.03574387,0.03661181,-0.015208514,0.020839667,-0.029493101,0.030761464,0.06082099,-0.02923218,0.011814924,-0.10895349,-0.12417609,0.061225377,0.031955454,-0.093449995,0.012728274,-0.09276543,0.024460426,0.014623267,0.18796472,-0.06733452 +4.4.1.14,"A pyridoxal 5'-phosphate protein. The enzyme catalyses an alpha,gamma-elimination.",384,0.99999994,-0.021841697,-0.07272469,-0.021175427,-0.039101347,0.046603777,-0.009177532,0.023291696,-0.045499936,0.043949656,0.08262294,0.045914307,0.058871724,-0.07998715,0.06318692,-0.025559574,0.03403114,-0.07555913,-0.016971376,0.0069158506,-0.07343861,0.07145586,-0.04047752,-0.0036247373,0.019292915,0.007054501,0.104231305,0.06784268,0.014013946,-0.04002343,-0.07457807,-0.045524452,-0.04807362,-0.02918235,-0.08417762,0.013407345,0.071579106,-0.11843256,-0.017746828,0.002403356,0.013653701,0.065914705,-0.059958037,-0.038628902,-0.0070991674,-0.09034049,-0.014764596,-0.006088582,0.031507492,0.0922094,-0.020325819,-0.064845234,-0.04533894,-0.034067478,-0.05177551,-0.021086501,0.04844198,0.016048506,0.014320733,-0.016150784,0.006811626,-0.023565212,-0.0022659467,-0.0315289,0.023517387,0.03329326,0.001513036,0.00868406,-0.058537766,-0.06908644,0.007899357,-0.077934645,-0.029070128,0.082372345,-0.05840591,-0.047497585,0.06307877,-0.031181296,-0.021988908,0.0039541367,0.0647597,0.03200779,0.0082116425,0.057718858,0.08808222,0.07952956,0.036841046,0.03689179,0.019314174,0.05880642,-0.015232377,0.0049903467,0.033156287,0.033966254,0.020347776,-0.03658293,0.06626973,-0.004988655,-0.0051572057,-0.023091242,-0.030233212,0.036559142,0.0011692512,-0.0039617224,-0.038659528,-0.09192111,0.040703587,-0.024624055,0.065077834,-0.008803057,-0.035404164,-0.048487,0.013630144,-0.00044840234,0.028575324,0.0065518147,0.06243761,0.05607448,-0.0020240778,-0.07694228,-0.0013535949,0.02198253,-0.031519987,0.0023832242,0.09538637,-0.07100539,-0.00067300466,-0.08864868,-2.4291018e-33,0.036242537,0.13901174,0.02409486,0.007504746,-0.02258529,0.021861453,-0.07709474,-0.013590523,-0.051386982,0.039015204,-0.0118245175,-0.048863135,0.048929527,-0.046035845,-0.05266386,-0.024099967,-0.03543031,0.07798319,0.05290996,-0.01328758,0.05869198,0.07082493,-0.03407176,0.023208974,0.0047968524,0.10604489,-0.088084355,-0.0017682763,0.008259168,-0.009141384,5.7463414e-05,-0.052153297,-0.12254016,0.0041086455,0.03536726,-0.08427275,-0.02954075,-0.03248998,0.013091449,0.053690597,0.0051611066,-0.043442585,-0.027243592,0.035501853,0.014560186,-0.10525026,-0.0055641644,0.058661964,0.006537838,0.014046371,0.010753986,-0.05584451,0.112565555,-0.020205062,-0.119771615,-0.018748917,-0.025332777,-0.032726046,-0.00822228,0.041289974,0.039929282,0.014598514,-0.058210783,0.0032598698,-0.052425478,-0.04392378,0.040919065,-0.080707975,0.069281094,0.06252014,0.027170068,0.050902624,0.105609156,0.0369693,0.032506004,-0.032631386,-0.016293958,0.04508924,-0.00783155,0.10842598,-0.036862154,-0.081134625,-0.020440137,-0.024338685,-0.010633206,0.024180654,0.014806753,-0.04519821,0.01982488,0.01966996,0.08188782,-0.124101035,-0.08346093,0.042021327,-0.02147596,9.1395815e-34,0.122287534,-0.10529932,0.049065568,-0.07196758,-0.09775904,0.007898055,0.0928286,-0.04643576,0.029196026,-0.014799301,0.040861256,0.042094707,0.0027689284,-0.038449243,0.0066615627,0.03333636,0.014794103,0.033534467,0.031774774,-0.00451151,0.04576619,0.04881331,-0.010721208,0.06640005,0.08763695,0.06338147,0.055201698,0.01205049,0.019913724,0.032915898,-0.027345898,0.011508079,0.041487224,-0.07749411,-0.02128814,0.02690414,-0.06827345,0.034408607,-0.015245438,0.019388627,-0.017889377,0.08730829,0.042101797,0.0011929782,-0.015859546,0.0633834,-0.016496371,0.049969416,-0.024183983,-0.04434763,0.030397443,0.03605628,-0.04257235,-0.021700844,-0.0064809453,-0.008298495,-0.033620976,0.0097709745,-0.0029774148,0.019633805,-0.0066019217,-0.03855923,0.065885015,0.06495093,0.03230241,0.09189036,0.04007452,0.030019386,0.008295871,-0.0018437592,0.008754935,-0.012703372,0.041939132,0.10978284,0.012064784,0.036589287,-0.014583449,0.0714121,0.03547136,-0.037718844,-0.014937329,-0.009270732,-0.07295658,-0.14279507,0.010844547,-0.030769402,0.052105628,0.10930935,0.04400291,0.01638478,0.004785085,-0.013823717,0.007309051,0.034259655,0.12193371,-2.4361553e-08,0.076338306,-0.031367183,0.009565032,-0.06865366,-0.00039814663,0.027777035,0.04408376,0.0067186276,0.13039014,-0.026466355,0.0008743824,0.02080907,0.055359498,0.036289446,-0.007757574,0.05025505,-0.03478417,-0.0030665086,0.008076823,-0.04070661,-0.067725495,-0.0105880005,-0.11534843,-0.028193865,0.07673585,-0.05716034,-0.030954432,0.015346718,-0.050633974,-0.04853045,0.039959315,-0.0005888255,0.0037100867,-0.058442485,-0.0013438963,0.117410846,0.008591141,-0.04459609,-0.06592668,0.008388724,-0.101869546,-0.07075792,0.00039260217,-0.04885561,-0.0489513,0.05090501,-0.07141368,-0.028853184,-0.014045966,0.014537228,0.024804002,-0.010794946,-0.092017196,-0.10952245,-0.11672218,-0.017881257,0.061624575,-0.035262447,-0.034488514,-0.10031218,-0.0062211165,-0.042434413,0.0961357,-0.1049664 +4.4.1.16,"A pyridoxal-phosphate protein. Dithiothreitol or 2-sulfanylethan-1-ol (2-mercaptoethanol) can act as the reducing agent in the reaction. The enzyme from animals does not act on cysteine, serine or chloroalanine [1,3], while the enzyme from bacteria shows activity with cysteine (cf. EC 2.8.1.7, cysteine desulfurase) [2].",384,1.0,-0.018709045,-0.03325024,0.03244649,-0.019414045,0.09423532,0.050042644,-0.03669322,0.043651138,0.08151057,0.027465073,0.021072084,0.005559838,-0.03628442,0.09849908,-0.039423577,0.05807775,-0.048732053,0.0921834,2.5836689e-05,-0.013256553,0.08008428,-0.011173643,-0.0316464,0.055271436,-0.047712423,0.074703075,0.042285267,0.018358363,-0.08821647,-0.03456992,-0.035938893,-0.08891785,0.023724604,-0.04266424,0.02360883,0.11222095,-0.088550135,-0.008234983,0.003427271,-0.039213788,0.04205564,-0.00063918676,-0.068460196,0.0041944413,-0.05293681,0.008501628,0.032890674,0.011339008,0.044077847,-0.06751488,-0.0967038,0.013700383,-0.03391007,0.033578493,0.0017776228,0.00089752703,-0.068490535,0.008460319,-0.010428298,-0.064498655,0.01768274,-0.01264962,-0.016661968,-0.028029699,0.056291133,-0.019705404,0.02555766,-0.06059086,-0.036755085,-0.068351164,-0.035854325,-0.020607896,0.097478464,0.012614227,0.015952084,0.04413179,-0.0532037,-0.021195132,0.018003836,0.010745971,0.0371125,-0.060832527,-0.0006305184,0.07173311,0.07304382,-0.029555604,-0.027109679,-0.034228332,0.01328338,-0.032528277,0.05022147,0.05025552,-0.0063405395,-0.034602724,-0.078527115,0.006432793,-0.011431277,0.048658736,0.0089714695,0.02294715,-0.034373824,0.030044297,-0.088699535,-0.13864231,-0.04751735,-0.00044527973,0.01739648,0.046285413,-0.045628965,0.0070809056,-0.04339387,0.0062522595,-0.009657652,0.04961976,-0.029100342,0.120609075,0.0989433,-0.030211266,-0.091185935,0.011276884,0.01344708,-0.0513883,0.074749954,0.08466638,-0.027890377,0.0771684,-0.10500929,3.2837787e-33,0.0659035,0.018196581,0.047285676,-0.06779795,0.053945456,-0.017193852,-0.033400103,0.021459058,0.0061009326,-0.08727118,-0.009602672,-0.02951524,0.058847528,-0.03148844,-0.035222102,-0.08227229,-0.03318819,0.028250001,0.11005404,-0.019586394,0.013553187,0.061792146,0.008176549,0.09633591,0.021125218,0.025980856,-0.058060657,0.0010108766,0.028428517,0.009060919,-0.011927575,-0.094794914,-0.12403618,-0.04859576,0.071797945,-0.044609655,-0.099856794,-0.046718553,-0.02487567,-0.016776,-0.09658229,-0.02823692,-0.0008462295,-0.028474238,0.004048468,-0.08355813,-0.06641223,0.07409314,-0.038508505,0.03624912,0.09808499,-0.07667066,0.04788549,-0.07810855,-0.07763673,-0.016187359,0.016923564,-0.032806054,0.020441659,0.0782555,0.03944722,0.035968214,-0.08340674,-0.024867702,0.036916528,-0.041244254,-0.0063964636,-0.041812003,-0.034998298,0.07562309,-0.014937977,-0.004786757,0.028173767,0.06057631,-0.008438043,-0.034465767,-0.019711114,0.041000698,0.048042644,0.020022083,-0.03546285,-0.023945658,-0.01899392,-0.008810486,-0.06046424,-0.012100801,0.013658141,-0.04268629,-0.0018039829,0.002450053,0.014336781,-0.119256765,-0.08170165,0.032076135,0.0116057675,-3.869188e-33,0.05601576,-0.07026901,0.067014016,-0.025715547,-0.07504171,0.07653746,0.054588057,-0.04144977,0.07288245,-0.015340536,0.06294363,-0.05957653,0.024396628,0.030137498,-0.019265452,0.0495102,0.018751599,-0.007513992,-0.009986793,-0.018799262,-0.03263727,0.076774746,0.037194606,0.053014826,0.07630627,0.03635727,0.009272377,0.115398966,0.043294974,0.0075857425,-0.045849353,0.058597695,0.012487672,-0.06238178,-0.036926642,0.053960226,-0.09293434,-0.014294174,0.047787204,0.06257914,0.013960386,-0.016963214,0.0056325863,0.10719992,0.012057134,0.049428876,-0.053396445,-0.0016374683,-0.0005977662,-0.041123286,0.036282856,0.060045533,-0.008704043,0.008140384,0.05642599,0.0363581,0.027198166,-0.048477408,0.005554133,0.00029187553,0.014911914,-0.087103345,-0.020019306,0.04181562,0.03792398,0.06344821,-0.015144371,0.0052615968,0.06372668,0.0061623976,0.0527165,-0.022625001,0.07466352,0.02531302,-0.04911629,-0.015968159,-0.046512913,0.08334804,0.0128580835,0.003437823,-0.0023039705,0.00030612192,-0.01088556,-0.10800856,-0.009550087,-0.06290095,0.016954182,0.105613165,-0.02151775,0.049979698,-0.023231946,0.012194537,0.037250783,0.10519656,0.065799154,-4.895201e-08,0.037377425,-0.0972757,0.07044727,-0.032808684,-0.01321545,-0.008470314,0.010406467,-0.01038399,0.018954424,-0.016161352,-0.013318084,0.057780914,0.017156862,0.028728765,0.06388279,0.035668604,0.033906575,-0.0020986611,0.0022707758,-0.043244142,-0.05192935,-0.027304292,-0.15271594,0.016432859,0.04497866,-0.07305798,0.024812387,-0.0203825,-0.09953407,-0.036028333,0.06098289,-0.01218294,-0.0004066024,-0.06355759,-0.021415927,0.057591185,-0.03892094,-0.06404378,-0.009926573,0.014048502,-0.053871483,0.05442934,-0.10685583,0.0027090474,0.06071416,0.033976927,0.008295151,0.02642683,-0.01492692,-0.00042673852,0.041852072,-0.010108606,-0.024541123,-0.07443044,-0.1288781,0.05428045,0.07553479,-0.046675287,-0.03840132,-0.09451825,0.039422363,-0.04971113,0.14434895,-0.0065722144 +4.4.1.17,"In the reverse direction, the enzyme catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links.",384,0.99999994,-0.039569136,-0.009030499,-0.029042935,0.0095819235,0.058812913,0.018889222,-0.039229803,0.111055225,0.02389464,0.016808202,0.035831243,-0.017092677,-0.04187127,0.014232576,-0.043052193,0.04070316,-0.07829094,0.042423744,-0.053860944,-0.055096757,0.03357097,0.029943189,-0.07891997,0.037731007,0.015273893,0.0056876023,0.06781368,0.00049748225,-0.029814472,-0.06382955,-0.04041077,-0.059774473,-0.0109003745,0.0030603658,-0.0016561764,0.0922613,-0.057801146,-0.07473939,0.014601059,-0.04817159,0.094402224,-0.052642856,-0.06585313,-0.059643697,-0.09145177,0.059132427,0.032703184,0.09083329,0.02703729,0.07891123,-0.02599669,-0.0132176345,-0.027141262,0.07371342,-0.07130498,0.080184445,-0.04131201,0.052233193,-0.032577828,0.03995186,0.027371515,-0.010776918,-0.08661139,-0.0065310206,0.09682091,-0.09686477,0.032159872,0.050805748,-0.056594983,-0.028723292,0.046713177,0.0026084953,-0.09936486,0.0038731685,0.02405191,0.023604868,-0.039048333,-0.005394995,0.037805837,-0.042560488,0.057682917,0.062017374,0.051708814,0.12747702,0.04380074,0.03049305,-0.026205368,0.009910249,0.028260648,0.0251013,0.07130798,0.026461313,-0.035368804,-0.04611625,-0.0185592,0.022299403,0.042730868,0.081202246,0.055334948,-0.001637689,0.028521108,0.01698538,0.020121539,-0.07192569,-0.021602841,0.008098497,-0.016981902,0.05607147,0.044161923,-0.026317794,0.026511097,-0.0140022915,0.15005068,-0.022160271,-0.058965288,0.08960868,-0.02022162,0.007335491,-0.02824514,-0.06282069,0.0051636435,0.0127928,0.010413153,0.055817727,-0.054610513,-0.016595537,-0.121928416,5.605699e-34,0.048929762,0.049126927,0.04728132,-0.043061335,0.013554459,-0.029923076,-0.08624632,0.05204634,-0.041001495,0.02511349,-0.026957484,-0.0676363,0.022193788,-0.043248605,-0.033129513,-0.122755505,-0.050026927,0.042798333,-0.0063168467,0.028704677,-0.0024599216,0.02538101,-0.05871817,-0.0023591327,-0.021144522,0.06259129,0.028018948,-0.0101259025,-0.0056370324,0.018908037,-0.045422193,-0.022947466,-0.019413488,-0.071573935,0.05599527,-0.027118135,0.025397256,-0.008411988,-0.063859485,0.03669946,0.009890122,0.013342147,-0.027025564,-0.07947885,0.01956225,-0.117246054,-0.029681064,0.02344761,-0.009671226,0.015207697,0.05675272,-0.09265175,0.11675394,-0.039267633,-0.0070052817,-0.029575476,-0.06805903,0.007973915,0.023286985,0.04867721,0.045804664,0.0512374,-0.08464696,0.043936696,-0.030536503,0.024098257,-0.04959665,-0.02854585,0.012150381,0.103938416,-0.059642475,0.04779736,0.038473047,-0.039714884,-0.028800208,-0.039103854,-0.1377856,0.024492284,0.11128366,-0.026330126,-0.031800807,-0.014872376,-0.032616664,0.02353209,-0.04709637,-0.065521374,0.03859003,-0.047795285,-0.071564816,-0.0030268528,0.08782498,-0.08319145,0.0069258213,0.038175214,0.04425388,-1.626001e-33,0.08461496,-0.03621992,0.021132872,-0.07133537,-0.03557343,0.049249787,0.043424696,-0.038826134,0.019172579,-0.0064531993,0.09013183,0.0073982347,-0.035479855,-0.0008271225,0.0378432,0.038512535,0.023421342,0.048319466,-0.062186528,-0.023036731,-0.009181783,0.016366119,0.053416993,0.019516017,0.035106678,-0.014299543,-0.0032096154,0.08691768,0.048797473,0.11868112,-0.011761664,-0.03701479,-0.016942374,-0.029782183,-0.025561118,0.10566667,-0.009507619,0.016190572,0.10586388,-0.040516675,0.02757619,-0.020060899,0.06511402,0.08394633,0.009971214,0.062003396,-0.12575996,0.035843845,-0.039783128,-0.10926505,0.03241221,0.013894055,-0.033707038,0.02795057,-0.044022843,0.023858879,0.0022930847,0.01956036,-0.034474615,-0.018666672,-0.07739708,-0.048452374,0.023492768,-0.026502535,-0.04403066,0.0010045995,-0.07137007,-0.022011574,0.016044127,-0.00255197,0.039671,0.051680584,0.025407175,-0.010292185,0.044745345,-0.045763902,-0.029667564,0.00055377395,-0.0066755763,-0.024070008,-0.046704657,-0.016052399,-0.01467174,-0.08854797,0.012203783,-0.03354022,0.007171976,0.110738836,-0.025673097,0.017662724,-0.06991186,-0.0103126345,0.025236402,0.10346536,0.051150553,-2.7088312e-08,-0.020125257,-0.15215766,-0.0027258557,-0.04484304,-0.018428978,0.11354642,0.0046574147,0.08192351,0.0053081335,-0.015584542,-0.005105495,0.08159849,-0.017270712,0.03516343,0.081391424,0.024748923,-0.01908344,0.0041869404,-0.023980182,-0.050957687,-0.028280523,-0.017463,-0.022346498,0.008122552,0.007895701,-0.03759804,-0.036331747,-0.019295858,-0.050538793,0.03581274,0.051691864,0.04548551,-0.06682112,0.018002966,-0.022897067,0.07812473,-0.06758941,0.023958001,-0.024225973,-0.027739687,0.020956432,0.02083382,-0.15125342,0.0068214475,0.03990611,-0.00082518597,0.0821175,0.06570539,-0.067642696,0.0035033447,-0.0066287653,-0.034604397,0.032433383,-0.04868762,-0.030299451,-0.037660502,0.025570689,-0.029322244,-0.043636575,-0.007745131,0.052634727,0.082113676,0.1683408,-0.03211581 +4.4.1.19,Requires Mg2+. The enzyme from the archaeon Methanococcus jannaschii catalyses the Michael addition of sulfite to phosphoenolpyruvate. It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite.,384,0.99999994,-0.08904641,-0.0030765845,-0.038569186,0.026082063,0.057069518,0.00036905461,-0.05251165,0.025289511,-0.016597003,0.01479026,-0.070256904,-0.028114187,-0.09285843,0.02828263,-0.041580267,0.022836411,-0.016541837,0.071744226,-0.003227568,0.011758881,0.16769224,0.0033304037,0.0072881617,-0.018479088,0.061489448,0.0128568765,0.041528888,-0.0082579665,0.005493657,-0.00018780761,-0.0041683945,-0.011468431,0.07837102,-0.12126676,0.035638887,0.14816691,-0.032268867,-0.05727202,0.007369153,-0.037803374,0.045986228,0.015767042,0.10621779,-0.03584328,-0.0025173922,-0.036405623,0.053904038,0.009580259,0.073688924,-0.044182975,-0.095052615,-0.025432836,-0.112386756,0.02236676,-0.0072263866,0.04845398,-0.121045455,-0.015689032,0.030807985,-0.073704734,-0.008916497,0.041818775,-0.0038661542,-0.01990214,0.050160278,-0.04919653,-0.006620699,-0.097554624,0.09318938,-0.009049902,-0.060511474,0.016727202,-0.007996809,0.01320626,-0.037939865,0.066696234,0.032545265,-0.039709233,0.06826668,-0.037654918,0.014272362,0.008238658,-0.012086662,0.027540995,0.034826346,0.013424001,0.034746274,-0.020001894,0.04046481,0.01711459,0.049648147,0.013777515,-0.017044084,-0.060603898,-0.0014222795,-0.0044131572,-0.024204941,0.09707715,-0.013857823,0.04360245,0.02387016,0.09101334,-0.017351868,-0.05085501,-0.02941818,-0.010583523,-0.0020750077,0.07617726,0.012139541,0.078085616,0.09056271,-0.029522419,0.05615306,-0.012476856,0.017231992,0.054447774,0.007842166,-0.133079,-0.08576845,0.05655884,-0.0035331855,-0.07620053,0.04746468,-0.01165469,-0.06587747,0.047495414,-0.08813474,7.384617e-33,0.012322992,0.027727429,0.068974115,-0.04971919,-0.060927544,-0.003047927,-0.12483715,0.019211628,0.019393722,-0.057811167,-0.114976875,-0.028467951,0.00026044573,0.0099109905,-0.054895017,-0.010601254,0.021054318,-0.00059758587,0.06045855,-0.011164326,-0.040047463,0.027916523,0.029586725,-0.025504107,0.056703605,0.036481783,0.08371046,-0.061512772,0.008177277,-0.0051118843,0.115916505,-0.11751199,-0.041955996,0.041728504,0.034539286,0.040566754,-0.055999834,-0.0772923,-0.0017245684,-0.02380589,-0.060507808,0.012637832,0.02173576,0.029740807,0.030010222,-0.048971433,-0.023074519,0.08332134,0.047379524,0.04120649,0.048844073,0.012017013,-0.007843863,0.04929796,-0.06580713,-0.016621765,0.014680398,-0.026223855,0.0959254,0.041538782,-0.018219355,0.041393127,0.0008211155,0.03757313,0.0104177445,0.0062605096,-0.06961811,-0.031709064,-0.006924181,0.037153464,-0.019876724,-0.06914358,0.025620176,0.05600895,-0.037866447,-0.033269092,0.045010503,0.0043505663,0.00444325,-0.026059588,0.024866693,-0.04614446,0.021157688,0.050804865,-0.08866639,0.017568663,-0.020669442,0.024641355,-0.00069556857,0.07076264,-0.036770415,-0.061165903,-0.047969796,0.06724842,-0.013134263,-6.63234e-33,0.066350505,-0.04979185,0.0071323207,-0.10200344,-0.0648396,0.04980447,0.04223946,-0.12158952,0.048263192,-0.056342505,0.04227556,-0.028043542,0.07986634,-0.049939517,0.026521744,-0.021628205,0.050726257,0.024733072,0.01887748,0.022034787,0.026266199,0.169113,-0.017629892,0.009301064,0.07347807,-0.030572679,0.022047728,0.04931783,-0.022742203,0.06395773,0.015900016,0.039209444,-0.06467649,-0.093438745,-0.08763521,0.02803302,-0.011371803,-0.010837208,0.012565369,0.052374125,0.054851517,0.017359663,0.027380541,0.065220565,0.018560579,0.00091987225,-0.034726117,0.015064102,0.022482341,-0.035740398,0.054271497,-0.068475254,-0.06664164,-0.04625089,0.04594184,0.10199998,-0.044278722,0.022950359,-0.042276513,-0.045542464,-0.032743856,-0.05089821,0.074885465,-0.14107108,-0.00864111,0.07020844,-0.004328325,-0.017158119,-0.0036763134,0.029110597,0.03592304,0.041668084,0.053659003,0.027432047,-0.011898734,0.04316354,-0.057329144,0.050529037,0.062842086,-0.0649256,-0.015375052,0.031795707,0.030327655,-0.039740708,0.03980014,-0.07290175,0.036558848,0.058167696,-0.01783891,0.0050357617,-0.0039366973,-0.057694525,-0.039577134,-0.0036561694,-0.02932187,-3.672888e-08,-0.0011894403,-0.03914868,0.0456018,-0.028490575,-0.049520172,0.041142892,0.075856104,-0.051585287,0.004842714,-0.019288367,0.057851966,0.033702143,-0.0023445396,-0.02052828,0.0012772334,0.019917604,-0.067447715,0.06709731,-0.088588454,-0.055759694,-0.009440758,-0.055552498,-0.102751,0.07518179,0.07723393,-0.05131982,0.06928118,-0.005888153,-0.0754164,0.01708005,0.04750345,0.009297053,-0.01928918,-0.030530388,-0.03879834,0.035264876,-0.019927738,-0.00476439,-0.03800448,-0.0937496,-0.022167964,0.006842745,0.028169496,0.019660939,-0.052948516,0.0010260347,0.0015527861,0.03654754,-0.05489695,0.05459785,0.09901879,-0.06320799,-0.0078114197,-0.07751739,-0.051239662,-0.05804456,0.06520698,-0.049181744,-0.06342744,-0.024731241,0.105154276,-0.008022574,0.10541719,-0.028457081 +4.4.1.20,"The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.",384,1.0,-0.06580607,-0.04429536,-0.0031096432,0.0021978102,0.075865984,0.016523562,-0.022485292,0.04463715,0.051204216,-0.008282527,0.13062966,-0.036213882,-0.033805914,-0.033572253,-0.054642215,-0.0018870165,-0.031014912,-0.023656847,-0.08536971,-0.09855824,0.01190542,-0.027626518,-0.0019476544,-0.017155116,0.031587884,0.04063816,-0.027672552,-0.052525118,0.0050540958,-0.08320674,-0.020249419,-0.047203444,-0.052536964,-0.04190617,-0.037049,0.021768754,-0.06639287,-0.04104946,-0.036749195,0.013807833,0.11006369,-0.03859089,0.005826458,-0.04777618,0.02221097,-0.03442588,-0.01674788,0.015652591,0.060181342,0.014587199,0.0036934838,-0.07114913,-0.051841747,0.029672222,0.009948206,0.04845221,-0.029707791,-0.002542301,-0.015241202,-0.00043580355,0.04027358,0.009973955,-0.005909365,-0.07857575,0.028930863,-0.07875376,0.041715406,-0.04346407,-0.042468656,0.012356462,0.005946567,-0.039911136,-0.01711782,-0.040346928,0.008126174,0.013986407,-0.068723924,0.0030920622,0.049303394,0.02040686,0.040315986,-0.09546587,-0.01436598,0.016260128,-0.020577392,0.017199839,-0.01811789,-0.017899578,0.029913105,0.013485918,-0.0024841565,-0.03208398,-0.039097946,-0.0011068123,-0.05814938,0.027119821,-0.0729053,0.10512795,-0.025507372,-0.03479824,-0.007370262,0.03563232,-0.07212248,-0.04511137,-0.036790255,-0.028837875,0.048465308,0.04194626,-0.014371483,-0.021801746,0.039930325,-0.030344058,0.04218315,0.036110297,-0.037018687,0.17433183,0.01039499,-0.031609356,-0.044134047,-0.05212671,0.09909462,0.01025876,0.020369498,0.05279024,-0.07300865,0.026360283,-0.035146203,-8.67026e-34,0.007472521,0.06458498,0.041362833,0.01668199,-0.022458449,0.07254897,-0.14945783,0.012325782,-0.018973034,-0.08306285,-0.09305446,-0.035979107,0.001354482,0.0015230168,-0.0800117,-0.0480159,-0.0020051638,0.045625325,0.049195465,-0.014539268,0.08523117,0.030951567,-0.07124606,0.02677112,0.036305476,0.056756124,-0.036432546,-0.031249532,0.040228266,0.00640823,-0.04598645,-0.02038512,-0.07073965,-0.0003460973,0.005818086,-0.007199946,0.023798209,-0.053933326,0.06020728,-0.019914847,-0.014861528,0.05912739,-0.04898659,-0.040726002,0.04111975,-0.049777325,-0.060375247,0.02104643,0.08910788,0.09717217,-0.0378969,-0.056905694,0.08299308,0.00081528927,-0.004759589,0.039036635,-0.029760905,0.037509304,0.033412997,0.09564844,0.013897089,0.18292585,-0.03974854,-0.027424186,-0.060987893,0.08754415,-0.04093523,-0.0066963998,0.014035854,0.058956034,-0.027878378,0.02156905,0.026392816,0.09736627,0.093694806,-0.085821,-0.09544335,0.022370515,0.006229159,0.010634707,-0.033893347,0.04609099,-0.0006081458,0.02324851,-0.046398416,0.03835179,-0.05250326,0.0011158715,0.03955248,0.088359,0.108513914,-0.0055145253,0.014383881,0.07304734,-0.002772895,1.9923024e-34,0.016754476,-0.07059725,0.017045047,-0.04639769,-0.0127531225,0.047770347,0.058518946,-0.020831944,0.121212654,0.02204937,0.11113869,0.024152702,-0.092633925,0.0025326505,0.024630263,-0.078720085,-0.046287216,0.08381824,0.042191666,-0.020585813,0.06627322,0.032856815,0.067305736,0.05711516,0.07782297,0.013947496,0.01955408,0.075004406,0.051843517,0.04205889,-0.023076912,0.005339001,-0.06058709,0.023158712,0.016917294,0.0084593985,0.014632117,0.060057145,0.023162104,-0.037999433,-0.040583104,-0.013783104,0.0559717,0.13643816,0.055491466,0.059355635,-0.016231995,0.029529804,-0.053778697,-0.08403539,0.0027125513,0.01637414,-0.09237503,0.014985738,0.037237696,0.013522381,0.071046494,0.004467566,-0.014451324,-0.035651606,-0.04982696,-0.061082304,-0.0011649645,-0.14363977,0.03509505,0.044547956,0.04388929,0.05011943,0.07501955,0.019044291,0.09234982,-0.004627269,0.021529218,-0.036984324,-0.031688754,-0.011344951,-0.010174003,-0.0126829175,0.04668234,-0.092994854,-0.04458141,0.031687647,0.037586674,-0.087663725,-0.00694925,-0.06860491,-0.015560799,0.12344585,-0.040363576,0.07009099,-0.09913032,0.008812764,-0.028121611,0.005175904,0.005485708,-2.5963585e-08,0.0043432754,-0.07222802,0.034227856,-0.009643279,0.03770158,0.036859363,-0.051306993,0.05310416,0.06677229,-0.028363675,-0.0628767,0.14110273,0.03799745,-0.0006729747,-0.03595151,0.01878008,-0.0011392761,0.000787376,0.007197632,0.014871271,-0.045385312,0.030319134,-0.08922448,-0.044723615,-0.07052528,-0.052684482,0.019357827,0.05367514,-0.050024427,-0.082245894,0.07992602,-0.014037892,-0.015204325,0.07532206,-0.037505925,0.0049911984,-0.013077171,0.06422983,0.021015394,-0.020265779,-0.05046338,0.002524629,-0.024656715,0.020697076,0.03882286,0.018709954,0.028492687,-0.08384008,-0.03250805,-0.014505926,0.034711584,-0.07160401,0.051147595,-0.025999976,-0.0596732,-0.022628903,-0.035774663,-0.09128566,0.033153523,0.019902319,0.04173491,-0.032768514,0.08874031,0.07924103 +4.4.1.21,"Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density [2].",384,1.0,-0.07459842,-0.057715315,-0.02449966,0.04447055,0.042022552,0.028700985,0.024906827,0.06244754,0.082473084,-0.027464135,0.00540449,-0.066880986,-0.016507003,0.017520342,-0.09399323,0.007061416,-0.061086744,0.0043977587,0.03785786,-0.032805804,0.02719751,0.042199347,-0.010250843,-0.0060209897,-0.08370429,0.041713834,0.03059249,0.011337484,-0.0062374007,-0.062341858,0.015245139,0.033937987,0.09281971,-0.12086003,-0.016206317,0.036974918,-0.02765215,-0.06416237,0.11359263,0.0031808328,0.039222185,-0.03117357,0.052449908,0.009112617,0.050388373,0.008862252,0.0051700636,0.06251228,0.08312794,-0.01505026,-0.093356684,0.0043466548,-0.016779754,0.044182945,0.101307936,-0.015216291,-0.009256225,-0.021098979,0.06831108,-0.03986245,0.09068118,-0.011118051,0.02462789,0.007558383,-0.058029655,-0.008185345,0.0238489,-0.019246241,0.017257722,0.02379303,0.0119563835,0.030784477,-0.029596543,-0.045806516,0.040817373,0.04850106,-0.020581162,-0.10460137,0.0024288814,-0.019297102,-0.009552984,-0.025689721,0.11146499,0.104501896,-0.0746391,0.011567298,0.00973984,-0.057429746,-0.0339045,0.025145484,0.0071570966,0.0050180466,-0.11159559,-0.07123462,-0.113963045,0.029551467,0.066827305,0.017204903,0.042540677,0.018673083,-0.040471386,0.035866704,-0.06764252,-0.027143221,-0.01565774,-0.044924706,0.017332468,0.03388177,0.0023754397,0.053547826,0.0030286936,-0.030843118,-0.0114766555,-0.018132549,-0.062067524,0.05368002,0.02388534,0.0024749625,-0.026442863,0.0005245988,0.048492905,-0.018595485,-0.021171808,-0.0036797212,-0.023476671,0.03095117,-0.09579167,1.3606251e-33,0.0052107275,0.036483817,0.058420178,0.023683876,-0.03255599,-0.0979358,-0.122790664,-0.03306031,0.0024505309,-0.069994226,-0.056726594,-0.04509307,0.04390046,0.011287847,0.015238323,-0.094955295,-0.10658209,-0.005820833,0.056519166,-0.058065854,0.054312523,0.0640122,0.017543407,-0.048477408,0.010377994,0.034155097,0.07149226,0.02018886,0.096817225,-0.0044026016,0.04280565,-0.06112163,-0.059312258,-0.052276187,0.122589424,-0.006016546,-0.04563263,-0.043977205,-0.08982717,0.014900425,0.012509482,0.04983486,0.0059169885,-0.012232975,0.0870234,-0.079576835,-0.060932916,0.06648487,0.016142545,0.06886163,0.007332853,-0.011257937,0.041372303,0.010170629,-0.032824147,0.009594434,-0.04862949,-0.03736723,0.012372094,0.0581885,-0.020997817,-0.027311087,-0.012511092,0.015754746,0.010694487,0.053447675,-0.06848858,0.009946722,0.06459185,0.05733289,0.009689669,0.011756357,0.07849834,0.037725195,0.0073739756,0.017317396,-0.07108246,-0.059179705,-0.0045760027,-0.00010654782,-0.02550756,-0.05598347,0.07080874,0.005438997,-0.043030806,-0.024039095,0.03522431,-0.045203824,0.017058965,0.010236076,0.07083285,-0.072501786,-0.043526765,-0.02675064,-0.06081098,-1.9235606e-33,-0.02552544,-0.086493924,0.04667326,-0.010048569,-0.042606913,0.023621617,-0.0041841646,-0.020420166,0.027049253,-0.02824973,0.08499593,0.08244125,0.0072013726,-0.04969684,-0.02662625,0.022722378,0.0131049,0.013802605,-0.04152663,0.0351748,0.024717644,-0.019167699,0.019144332,0.038592894,0.017027432,0.093898326,-0.020616561,0.02031253,0.025661878,0.15085326,0.026298454,0.009641821,-0.03622592,0.007418716,-0.004357461,0.07576389,-0.008353345,0.00453423,-0.02108923,0.062468994,-0.040518813,0.0018541891,-0.04904654,0.10064121,0.06086909,0.10062751,-0.017778056,0.15587214,0.01719428,-0.0012759275,-0.019364113,-0.04617514,-0.049712766,0.017005434,0.014855244,-0.027456477,0.08398979,0.07044003,-0.0020954844,0.05587218,0.015743198,-0.05538063,0.0859934,-0.022232281,0.04016013,0.017081896,0.021877006,0.063601255,0.0155703,0.0023549746,0.002768852,0.08814782,0.061575007,-0.02176145,-0.00091749587,0.033780005,-0.08565619,-0.09638828,-0.08608361,0.08209438,-0.060884897,-0.02173175,-0.044832624,-0.020190062,-0.033308193,-0.13378489,-0.002096241,0.06599517,-0.075464524,0.049460083,-0.04360253,0.045827966,-0.0012512198,0.043993324,0.023869675,-3.9187494e-08,0.016439306,-0.042577397,0.043941226,-0.049663022,-0.017800177,0.004117883,-0.054663807,-0.031473827,0.047151472,-0.034006014,-0.0046268394,0.04316187,-0.019442176,-0.019196942,0.08421365,-0.000865886,0.029843051,-0.017604241,-0.077572644,-0.06423678,-0.05066484,-0.02372487,-0.12621172,-0.06904068,0.03306794,-0.0978693,-0.004185609,-0.05037371,-0.02694006,-0.040799957,0.0760328,0.051144704,-0.02752947,-0.0044328864,-0.06441571,0.07280755,-0.06318204,-0.007793198,-0.046716828,0.03430987,0.015123495,0.03227178,-0.18284908,0.0057712304,-0.021980789,0.015420373,-0.03743433,0.050955415,-0.043934923,-0.018886238,0.0053841053,-0.04709557,0.06669478,0.0078177955,-0.06446901,0.040456377,-0.009974564,-0.0042446856,0.053464502,0.0041216454,-0.08364033,0.013924047,0.16571908,0.02284657 +4.4.1.22,"The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway.",384,1.0,-0.090956196,-0.050329402,-0.07622202,-0.015044033,0.07018129,-0.017745653,-0.07215834,0.021550814,-0.013141734,0.021409659,0.052261185,-0.052628886,-0.008498268,-0.008449333,-0.055851437,-0.031005083,-0.0724817,-0.04515088,-0.009097196,-0.0641262,0.01939016,0.037031498,-0.11950571,-0.0044872398,0.07832491,-0.019233087,0.034424316,-0.010959812,-0.07156148,-0.03378873,-0.010050786,-0.081248544,0.007874424,-0.0396004,0.093395114,0.067024775,-0.05062506,0.01254781,0.08781116,0.0045696236,-0.021451386,-0.018783888,-0.04015708,-0.037442084,0.02740758,-0.018941263,-0.017852154,0.09906818,0.020536512,-0.04282552,0.027759448,0.013672986,-0.016943889,0.036534954,0.07583818,-0.035674058,-0.026031809,-0.006171561,-0.025581187,-0.039701715,0.0066824206,-0.035315473,-0.043263186,-0.029998431,0.042808756,-0.048210222,0.09487703,-0.040536966,0.036345452,-0.00094794173,-0.09230553,-0.025701141,0.015976416,-0.0060341144,-0.026604239,-0.00851338,-0.053899806,-0.06423719,0.04309901,-0.023778453,0.11416985,0.00043910506,0.010766788,0.10022902,-0.010697795,-0.059771854,0.009167105,-0.081841476,-0.0063545825,0.021255177,-0.028127596,-0.03624924,-0.06816486,-0.034732103,-0.08235309,0.06480483,-0.010779452,0.16462053,0.036723383,-0.0377964,-0.077266306,0.03506122,-0.023043018,-0.057052907,-0.031131888,-0.015789818,0.055061672,0.12085103,0.09995866,0.04862606,0.022432039,-0.004979486,-0.0131933,0.02671672,-0.017775875,0.11848278,0.128359,-0.07480103,-0.084637396,-0.11068979,0.04577639,0.01003523,0.05035149,-0.043043002,-0.013501469,0.02884678,-0.028474836,1.5115175e-33,0.089954525,0.0020748184,-0.0038526924,0.021293867,0.019071747,-0.05698184,-0.12273213,0.0397139,0.06367445,-0.020242535,-0.094302684,-0.06398737,-0.005747025,0.022665974,-0.07831067,0.035250805,-0.044353306,-0.026891429,-0.014871705,0.022692686,0.03119919,0.027818259,-0.045518696,-0.016663343,0.03935175,0.031655453,-0.020571718,0.013532681,-0.0029035031,0.0008420746,0.013934908,-0.08402329,-0.068941906,0.039813533,0.046422817,-0.019482372,0.016409844,-0.011074319,0.03639322,-0.010446099,0.030058637,0.055859193,0.004367836,-0.041599628,0.0026609935,-0.018247392,-0.006192365,0.08681179,0.016009357,0.1085435,0.035981923,-0.031046798,0.11677659,-0.049040303,-0.040532548,0.026492843,0.0011948489,-0.070286386,0.060198035,0.07436995,0.005341685,0.06515097,-0.047765777,0.042424344,0.055007398,-0.0035627794,-0.050244216,0.061622996,0.07444211,-0.004422363,-0.0928709,0.05168237,-0.008708742,0.0032443535,-0.015459414,-0.012641626,-0.05900621,0.04187119,-0.012228479,-0.049723085,0.0029349471,-0.009129011,-0.020943947,-0.0040438236,0.019444164,0.02523554,-0.037800074,0.0018948771,0.028017512,0.0010447255,0.0045130486,-0.0046951794,-0.013287114,-0.016737588,0.008619707,-2.8382563e-33,0.10864218,-0.09253473,-0.031538714,-0.042485245,-0.010798415,0.091018304,-0.03808362,0.026912399,0.060224738,-0.008049723,0.07471375,0.04103621,0.009978411,-0.0024562543,0.036532167,-0.04567641,-0.060499717,0.054530215,-0.095784836,-0.09533892,0.067915656,0.033673428,0.020178176,-0.04254638,0.05797423,0.0031157397,-0.033863362,0.09124089,0.048186176,0.062267635,-0.025359334,0.031085666,-0.018704295,0.0110922605,0.06075891,0.054264814,-0.07449031,0.040584512,0.022228038,-0.020946458,-0.0047649317,0.025595397,-0.03733036,0.10967346,0.06022685,0.03099816,-0.099421114,-0.05408834,0.0020590567,-0.023804318,0.08256622,-0.017808195,-0.038159233,-0.007638998,0.01638692,0.052694973,0.021389065,0.032393754,-0.019610586,0.027783787,-0.06038786,-0.053574793,-0.047671527,-0.0486298,-0.013638462,-0.022332642,-0.0077341776,0.037104595,0.026332343,0.014226534,0.048911445,-0.0131139625,-0.061714854,0.0039797584,-0.091068335,-0.09501678,-0.050222125,-0.0076833502,0.06590209,0.018871587,0.03361882,0.014343588,-0.0019088319,-0.06635287,0.02853178,-0.045557734,-0.04687219,0.102258034,-0.06832269,0.017415185,-0.06647532,-0.010687324,0.009592301,0.049641583,-0.06325831,-3.7028464e-08,0.011461941,0.04379654,0.03951282,0.045238957,0.031112505,0.08226906,0.044920955,0.01171095,0.019761052,-0.065619625,0.05154707,0.08985154,0.01057072,0.0142987855,-0.011937182,-0.013039615,-0.03493679,0.00567438,-0.054178186,0.02397185,-0.05584965,-0.02936319,-0.17527407,0.03436903,0.036025632,-0.031038979,0.08756916,0.01670382,0.02390698,0.0060745846,0.020426098,0.07464117,-0.04552792,-0.029098526,-0.11800479,-0.017595474,-0.015659649,0.059825987,0.010991522,-0.023894662,-0.0041439733,0.004680065,-0.10934827,-0.02280569,-0.02311494,0.00755893,-0.006807372,0.009199157,-0.089564465,0.102995284,0.08229981,-0.028031103,0.033887986,0.02672668,-0.08903147,0.00079508405,0.0033842332,-0.022724606,0.0024714167,0.01486163,0.019150313,0.018089833,0.158086,0.06851074 +4.4.1.23,"Requires zinc. Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts. The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile. Uses short-chain epoxyalkanes from C2 (epoxyethane) to C6 (1,2-epoxyhexane). This enzyme forms component I of a four-component enzyme system (comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.",384,1.0,-0.036588036,-0.03844237,-0.058343247,-0.04691235,0.07133598,0.0750216,-0.09229272,0.04502316,-0.056423075,0.023179725,0.0023164172,-0.09498701,0.03465646,0.021048313,-0.010468238,0.010872264,-0.089343935,0.025638862,-0.019610034,0.00045936785,0.017696813,-0.007959738,0.026309913,0.024999987,-0.01712338,-0.02503832,0.055072043,0.030046692,-0.06616281,-0.051241234,-0.03356076,-0.010256714,-0.007014164,0.015698941,-0.049773898,0.10061324,-0.09207834,0.025629168,-0.009685886,-0.03863225,0.018228408,0.053226985,-0.06754744,-0.033421997,-0.011195529,-0.07061242,-0.0024883568,0.030519322,-0.0499457,-0.0034977272,0.029578893,-0.019938827,0.016634047,0.04646959,-0.031320613,0.030493084,-0.099510856,-0.0353782,-0.009510599,0.021812908,0.0361493,-0.05138975,0.01012911,-0.0076840157,-0.009074979,-0.03831091,0.031463683,-0.0665019,-0.06143588,-0.04629384,-0.116831616,-0.011283223,-0.030551707,0.08375024,-0.052756224,0.017432015,0.029140685,-0.06920848,0.054410588,-0.019945014,0.023432475,0.06478737,0.029327048,0.06730431,0.095731825,0.018039638,-0.050245017,0.029904936,-0.010407559,0.03691995,0.14492577,0.00040525277,-0.048196707,0.023642495,0.014313076,0.029914232,-0.012255932,0.039967917,0.07678906,-0.009552964,0.054991484,0.008428542,0.0072241435,-0.0973474,0.02837647,0.026493609,0.06085707,0.048963472,0.006855369,0.03024375,-0.014290354,-0.061558437,0.05911338,-0.047913045,-0.04909339,0.11965642,0.0031314532,0.0061314283,-0.009817065,-0.02572878,0.03133357,0.020415803,0.00973777,-0.011590331,-0.023154542,0.0024867903,-0.0813358,4.4301546e-33,-0.00060444884,0.0843216,0.046513617,0.016090093,0.03797423,0.08723677,-0.020082023,0.1004066,-0.026836433,-0.006192082,-0.115315124,0.019247813,-0.0025275361,-0.030075405,-0.065655544,-0.042273957,0.017729228,0.037439894,0.010797753,-0.03508781,0.016095854,0.049380224,-0.091566004,0.02317207,0.002836773,0.014642793,0.0097678555,-0.01087689,0.043175176,-0.030250138,0.029802492,-0.048154715,-0.033715222,0.0144810965,0.06966293,-0.061154187,-0.016916147,0.016097425,0.0034623798,-0.020054484,0.08063571,0.0033795221,-0.06305047,-0.012329009,-0.00699086,-0.13626298,-0.05562603,0.080272846,0.058470424,0.03928343,0.09632792,-0.021529151,0.054465324,-0.03865243,-0.086389005,0.03551485,-0.05526907,0.033417117,0.10544037,0.05758485,-0.054099437,0.055787344,-0.03557306,0.007156055,0.032771513,0.022062203,-0.09679359,-0.02399446,-0.12388858,-0.00039765643,-0.015326267,-0.016884683,0.05568173,-0.0107036205,0.059407372,0.011653152,-0.07996935,0.03813703,0.051966153,-0.042840965,-0.0756103,0.041836485,-0.01517024,0.034400117,0.01002769,-0.04988089,-0.060922798,-0.016586348,0.018305847,0.07450574,0.08997846,-0.09454404,-0.06998001,0.034174234,0.039966367,-5.111123e-33,0.044355743,-0.028385008,0.082462594,-0.08825689,0.065389834,0.065980986,0.10013557,-0.0828814,0.04386884,-0.0627907,0.113593355,-6.949654e-05,0.060308557,-0.019856028,0.01049138,0.08719206,-0.046784777,0.10206447,-0.002237911,-0.0010462569,0.015553764,0.0354875,-0.016965881,0.020774059,0.00992153,0.040465344,0.0032718843,0.01210124,0.1469642,0.08577677,-0.005602079,-0.045604933,-0.061547793,0.032625932,-0.071160786,0.014291517,-0.06491412,-0.01141723,0.009357961,-0.0068546305,-0.041408498,-0.06936991,-0.030091317,0.062949054,0.06370989,0.054014686,-0.08551041,-0.03775929,-0.00942504,-0.023153368,-0.037081927,0.05672491,-0.07420925,0.044157423,0.004854758,0.074930936,0.004589821,-0.045514822,0.03757842,-0.056903895,-0.025658153,-0.0050493707,0.009643154,-0.0133276135,-0.011692575,-0.020638935,-0.014542738,0.07894478,0.04193592,-0.07395073,0.025621828,0.012314448,-0.031785153,-0.07428076,0.033002637,0.03212352,0.001448888,-0.031166947,0.006883188,0.0047832066,0.062651984,0.028667135,-0.012424801,0.01877828,-0.07393337,-0.0554081,0.0555403,0.09134955,-0.030777767,0.031677924,-0.023878051,0.024568373,0.004428401,0.115949385,0.10542785,-5.591483e-08,-0.008287662,-0.104745515,0.052609805,-0.11978604,-0.021517504,-0.03352947,0.066051446,0.026795056,-0.023035316,-0.09462746,0.03857834,0.08810271,0.034777537,0.009654841,0.048587345,-0.034564868,-0.0074999146,0.046333794,-0.012911001,-0.0064958814,-0.04527664,-0.006539996,-0.0742439,0.00724501,0.0009730186,-0.06538249,0.0052453787,0.00047377913,-0.084039,0.030145137,-0.010384391,0.027496107,-0.019597499,-0.0037260724,-0.08191394,0.03176317,-0.02582508,-0.021307511,-0.05603677,0.009146544,0.009996882,-0.039012294,-0.051775783,-0.010760982,0.07660543,-0.05634388,-0.039940335,0.089825876,0.050781287,-0.012056496,-0.018130835,-0.014485818,-0.06757003,-0.089168176,-0.013024928,0.041134782,-0.03842585,-0.023619374,0.0020005482,-0.022357976,-0.032754984,0.01599857,0.17669569,-0.062036972 +4.5.1.2,"A pyridoxal-phosphate protein. The enzyme cleaves a carbon-chlorine bond, releasing a chloride and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme's activity can also result in beta-replacement reactions, e.g. in the presence of hydrogen sulfide it can convert 3-chloro-D-alanine into D-cysteine and chloride.",384,1.0,-0.06669982,-0.03979712,-0.02789968,-0.04920683,0.07060502,0.036338404,0.049526636,-0.008199825,0.058250397,0.09277207,-0.014942408,-0.014003354,-0.082153454,0.10603399,-0.014612073,0.07867027,-0.0619987,0.03574334,-0.014636362,-0.0335018,0.07176871,0.011488678,-0.051583372,0.037267346,0.030409671,0.08446439,0.072985105,-0.0043893885,-0.02364139,-0.081732936,-0.09100076,-0.07102704,0.054596685,-0.08244969,0.068883225,0.10664851,-0.10018562,-0.009634567,-0.010005833,-0.035371467,0.033338934,0.016157346,-0.0532973,0.0030797522,-0.04289279,0.008587215,0.017713228,0.040544428,0.034733776,-0.027409017,-0.022119544,-0.0029977534,-0.032099016,-0.0068902136,0.011647461,-0.002848437,-0.058304433,0.031043563,-0.038870297,-0.035288125,0.04388313,0.044071417,-0.029026927,-0.019547483,0.049459364,-0.043614887,0.035671186,-0.055856977,0.021804253,-0.02731356,-0.07871201,-0.07372666,-0.03548263,-0.017186547,0.05962844,-0.0030727924,-0.0027931754,-0.036325727,-0.021110777,0.011545745,0.033432744,-3.9496867e-06,0.03933319,0.029994154,0.07313841,0.0070939176,0.015382867,-0.020155067,0.05084098,-0.023706168,-0.05355677,0.0034677952,0.024535611,0.015326394,-0.0077655436,0.054769684,-0.014651008,0.021459825,0.053415075,-0.02153605,0.016434835,0.13228546,-0.08916628,-0.10871717,-0.049773075,0.016072052,0.0070430064,0.09213381,0.027816895,0.02477897,-0.06347513,0.015781851,0.060315713,0.064591415,0.0063849,0.11789153,0.07812627,-0.013121661,-0.04579632,0.038731817,0.0649941,-0.013051703,0.026349891,0.12623863,-0.09274308,0.092873745,-0.14112163,6.744747e-34,0.024598641,0.007948334,0.043242328,0.06058609,-0.042504076,-0.057854004,-0.095868096,0.0102447765,0.0020471606,-0.07010764,-0.035039842,-0.0336201,0.083686195,0.019990277,-0.011860475,-0.0787568,-0.017673884,0.05667873,0.10984327,0.04188996,-0.0033642806,0.08496776,-0.039588418,0.06960906,0.030777123,0.06607692,0.010604931,0.06043325,0.0698656,-0.03291083,0.03478333,-0.09782758,-0.12752078,0.016783135,-0.0135376295,-0.04550136,-0.054061778,0.016079891,0.006409028,0.06789039,-0.08105086,-0.022887634,-0.03862722,-0.033525273,0.040495325,-0.10957778,0.015689999,0.07379289,0.0016469419,0.0006034143,0.0316391,-0.018398054,0.043755908,-0.04935659,-0.093328916,-0.007068499,0.035179365,-0.03306856,0.018223198,0.06952297,0.04751808,0.06472876,-0.059607536,0.007766496,-0.03143307,-0.054186985,-0.02916027,-0.10553617,-0.024673775,0.05614794,-0.092579,0.004283266,0.030977065,0.004158737,0.0040494865,-0.08127744,-0.09417233,-0.007753996,0.008461181,0.030097177,0.0011236017,-0.0124410475,0.01732847,-0.00060289574,-0.032109518,-0.071318835,-0.010463175,-0.08913139,-0.02143425,0.034780633,-0.00027426003,-0.0726049,-0.052082658,0.009527741,0.04673155,-2.3383521e-33,0.10194223,-0.090363905,0.0033060685,-0.04468862,-0.06883735,0.04993872,0.02527038,-0.008825869,-0.00437253,-0.049148858,-0.00090472423,-0.02116207,0.028194059,0.0076596686,-0.0042908303,-0.024507929,0.0042968118,0.027780423,-0.0031151127,0.005248047,0.049547523,0.089332595,0.011861879,0.023262547,0.034638796,0.05822302,0.015762642,0.04816748,0.044953078,0.058250014,-0.056852527,-0.0015725866,-0.03197788,-0.015019125,-0.05697704,0.083450474,-0.042623002,-0.063282624,-0.054586485,0.04047856,-0.019666541,0.040350568,0.05289413,0.010011381,0.018203333,0.05166595,-0.03149096,0.00073359493,-0.005291564,-0.026098229,0.0870839,0.040121038,-0.016026258,0.0074250186,0.008517174,0.010508711,-0.022159029,0.011906695,0.033320107,0.04603497,-0.020940596,-0.075723656,0.007154792,-0.027199484,0.019368995,0.013797915,-0.02366206,0.054255314,0.030464342,0.035536215,0.08343572,0.00025373726,0.025871247,0.01896306,-0.008678129,-0.045175437,-0.03166671,0.008686052,0.034569874,-0.0762472,-0.047963522,-0.0006696297,0.015681325,-0.05356818,-0.006467289,-0.08412498,0.022666393,0.0496946,-0.030728148,0.020324733,0.013762378,-0.05447422,0.00086112,0.1459796,0.09057631,-4.6356003e-08,0.0595619,-0.08804041,0.015697367,-0.028147776,-0.02282697,0.008112664,0.034541097,-0.0069877957,0.053372357,-0.047012407,-0.028084874,0.016342405,0.05938064,0.035272032,0.03648659,0.056751944,-0.0017501188,0.0572986,-0.010601962,-0.061462827,-0.07832377,-0.0006425153,-0.1903686,0.04410301,0.026031123,-0.054986835,0.025803931,0.024084944,-0.025591986,0.033596814,-0.003647414,0.017441608,0.038507283,-0.071636446,-0.01671124,0.010045293,-0.06962806,-0.04174372,-0.044032644,-0.038032204,-0.008413464,0.039809186,-0.11673138,0.020962887,0.03951644,0.0105582,-0.022754824,-0.003099635,-0.019854896,-0.008923106,0.09433597,-0.022039913,-0.011131278,-0.07245403,-0.11552343,0.06622233,0.011648153,-0.09051789,0.016918391,-0.05213033,0.03917628,0.011950374,0.14468704,-0.049897533 +4.5.1.3,Requires glutathione.,384,1.0,0.031799406,-0.00080141326,-0.034631733,0.05818852,-0.04187988,-0.024202956,0.029669195,0.04282265,-0.056916416,-0.052727956,0.057687163,0.0006268203,-0.04304536,0.07254604,0.0030608948,-0.03087592,0.08608664,0.0017139174,-0.09093491,-0.044127785,0.033745226,0.016081043,0.016326033,0.0011223272,-0.044907898,0.010500552,-0.03226072,-0.04924099,0.020458248,-0.012234897,0.0022107165,-0.059014216,-0.02920715,-0.012015091,-0.038620032,0.02310073,-0.07489638,0.023135442,-0.011135005,0.004416837,0.03152258,-0.054293968,-0.012090619,-0.0041205185,0.04482392,-0.013627732,-0.014967864,0.024581065,0.039133005,0.02652562,-0.04160971,-0.012133684,0.020293398,0.0603625,0.03348705,-0.052839078,-0.0134865455,-0.06578589,-0.035225373,0.07437702,-0.049230266,-0.027469065,-0.04994959,-0.07558939,0.043673757,-0.032100834,-0.0018969978,-0.028533734,-0.03532996,0.0767251,0.029015116,0.0066586696,-0.023049938,0.050702356,-0.0709659,0.0042091548,-0.05815924,-0.081385665,0.10376061,0.032166686,0.035092823,-0.010022221,0.058603544,0.16920199,0.083397165,0.043053843,-0.03659513,0.009940922,-0.10379691,0.02018152,-0.022065254,-0.009695022,-0.036037035,-0.0049658907,-0.035329346,0.031606562,-0.080695264,-0.02171328,-0.1464816,0.05632613,-0.064479396,-0.021317935,0.0036084985,0.005968582,-0.10992338,-0.025253806,0.03595764,-0.021866476,-0.005936008,-0.015697692,0.0043971194,0.00043790444,-0.0013324672,0.02714479,-0.05279986,0.10870936,0.121007785,-0.03521508,-0.10322232,-0.006055828,-0.0010362137,0.0048499913,0.02732655,0.012462791,0.010311021,-0.05990361,0.073653355,1.6586892e-34,0.07666433,0.047772914,0.042219795,0.013516533,-0.0017832456,0.07829015,-0.08644792,-0.08280796,0.03470618,-0.103049554,-0.06057781,-0.056843925,-0.0846477,-0.0145024285,-0.0086211115,0.026090499,-0.0133229615,0.015408323,0.1051163,-0.03531272,0.07423507,-0.04354645,-0.050896734,0.006422868,-0.04245457,0.08510937,0.03282187,-0.012861452,-0.007022109,0.022607282,-0.01459513,0.027692318,0.026827382,-0.026536027,0.014369468,0.009352657,-0.058229674,-0.05027746,-0.027201047,0.0040878695,0.033087105,0.046760384,-0.041394558,0.016675364,0.09500016,-0.017562069,0.0064748847,0.011181031,-0.022616642,0.11712364,0.022899916,0.010664204,0.047320023,0.045105916,-0.034675762,-0.0042412495,0.018721532,-0.06988224,0.041171752,0.050644726,0.009506465,0.052475028,-0.042099778,0.06070285,-0.011809081,0.016391369,-0.05710494,0.030369282,-0.10406207,0.056170363,-0.01140003,-0.09777984,-0.0217324,0.07834836,-0.045092523,-0.052315023,-0.0045958725,0.04611914,-0.02683486,-0.088785365,0.013614023,-0.045466673,0.008203298,0.065603696,-0.046032462,0.019850768,0.01720682,-0.01201281,0.057968374,-0.059934426,0.07335079,-0.032664146,0.017651575,-0.01419378,-0.07886685,-6.1525495e-35,0.035346016,-0.079382226,0.030345174,-0.0025853075,0.10177987,0.051424883,-0.02688741,-0.09329384,0.06677825,0.033372384,0.017679688,-0.00061387167,-0.020276131,0.021230683,0.061983906,0.01370705,-0.020201955,0.05672798,-0.037460342,-0.019429391,-0.0065830126,0.08215761,0.056126107,0.08276752,0.056750607,0.039772727,-0.006020543,0.01782254,0.03418335,0.066449605,-0.009779076,-0.0020091396,-0.13563207,-0.08002876,-0.00043974884,-0.0038309812,-0.006129788,0.049697172,-0.045463014,-0.020619784,-0.0009577702,0.03731303,0.017140243,0.16842242,0.0459697,0.05432727,-0.012618404,-0.0028625177,-0.05060469,-0.011696556,-0.00024431464,-0.03468021,-0.034128353,-0.04301139,0.04111296,-0.051107775,0.018148266,-0.05035313,-0.062027905,-0.008450606,0.01425408,-0.065949686,-0.08549023,-0.050792947,0.03967721,-0.026665382,0.08266546,0.03701266,0.06712915,0.08863814,0.028506977,-0.015167457,0.09022511,0.0118106725,-0.04033274,0.046675786,-0.065956675,0.0810287,0.030545644,-0.056955185,-0.03710278,-0.054333717,-0.0046023065,-0.05781556,0.032139953,-0.062178392,0.004217207,0.013180663,-0.0113637885,0.07780607,-0.08449359,0.0028718817,0.0045940657,0.05554712,-0.024723774,-1.8743705e-08,-0.0007737308,-0.026674066,0.051502854,-0.017140668,0.0032609913,0.022823162,0.044201672,0.032815255,0.07225142,0.042581957,0.02075422,0.12716737,0.068170115,0.082420304,-0.033151034,-0.0068866895,0.063652396,0.07929045,-0.033390485,0.004455453,-0.16504528,-0.04726701,-0.044776622,-0.016402967,-0.03894474,-0.04246539,0.030083364,0.04702898,0.03110553,0.06757264,0.08851798,-0.05217078,0.0014554765,-0.018236227,-0.10471476,0.0200973,0.0047933906,0.035157524,0.0065038814,-0.09430368,-0.039649293,0.13713445,0.0021407977,0.043948986,-0.014509191,-0.062392253,-0.009044058,-0.033308856,-0.004008113,0.03331727,0.044673815,-0.022648783,0.03623862,0.013395196,-0.06246989,0.03184647,0.030924888,-0.04155336,-0.006611926,-0.07546613,0.06159666,-0.035752416,0.11137494,0.082300976 +4.5.1.5,A pyridoxal-phosphate protein.,384,0.99999994,-0.027926307,-0.082669966,-0.06864404,-0.0736116,0.027612139,0.00069278304,0.043136388,-0.0022198383,0.07759752,0.061581366,0.050052542,0.024383662,-0.07972978,0.075630225,-0.018062996,0.011146767,-0.058814332,0.026981099,0.028646505,-0.060484987,0.08062581,0.046058796,0.013964545,-0.0034948976,-0.022635197,0.09317548,0.03897881,0.08481283,-0.022757838,-0.06512055,-0.033645604,-0.002438178,-0.04265655,-0.081326276,0.049699727,0.09206192,-0.10426549,0.024624566,0.01641356,-0.038264256,0.09138554,-0.06995117,-0.019178458,0.015225969,-0.079754055,-0.009005391,0.060174454,0.06121611,0.1076781,-0.0044863066,-0.08720911,-0.014019634,-0.013987518,-0.049955927,0.010103739,0.04439458,0.025756652,0.03877331,-0.030249724,-0.031439897,-0.018875996,-0.014899653,0.033183742,0.03005634,0.045147188,-0.03863779,0.011696549,-0.046883464,-0.028674698,-0.0040879943,-0.0399809,-0.0017529497,0.12130531,0.0010538863,-0.034636367,0.09728037,-0.028074443,-0.023704544,-0.04040873,0.055432733,0.03498061,0.00886843,0.038521856,0.08173242,0.056242175,0.02956211,0.015032759,-0.008670652,-0.0671204,-0.03498028,0.0024070852,0.025017837,0.033844747,0.03431295,-0.017365431,0.020294111,0.0095834825,-0.017277373,-0.049156386,-0.05037137,-0.0135520855,0.006560372,0.029906176,-0.04925029,-0.040218767,-0.005961301,-0.070319004,0.04136831,-0.008511003,-0.0040058997,-0.05803713,0.0810462,-0.012979407,0.006107804,0.023426063,0.022639925,0.016739301,-0.004660274,-0.05652102,0.057704583,0.0031750596,-0.032194667,-0.030190036,0.08859248,-0.054773755,-0.0542106,-0.07686096,-2.4678308e-33,0.06313784,0.074121,0.050783433,0.040298108,-0.011358971,-0.014224093,-0.06284932,-0.054584622,-0.06972202,-0.006010194,-0.005837788,-0.041249312,0.07401363,0.007710753,-0.07779482,-0.03148981,-0.09894455,0.03780528,0.09449977,-0.054316152,0.036347546,0.122786574,0.015729465,0.06573166,-0.023447253,0.10535222,-0.04718892,-0.017551308,-0.020911029,-0.010473525,0.017130276,-0.08890346,-0.10486213,-0.037216794,0.029635139,-0.1032107,-0.053137314,-0.088244945,-0.028490026,0.010690034,-0.031340834,-0.06654564,-0.015844474,0.03225437,0.005228752,-0.12502499,-0.022130616,0.049036965,-0.04441586,0.030425001,0.03924025,-0.065284304,0.07721513,-0.0022649365,-0.14055419,-0.054724984,-0.056979842,-0.04121839,-0.0039615375,0.036306877,0.055933136,-0.0074688112,-0.0776967,0.005927369,-0.007340223,-0.05244896,0.01644481,-0.06923204,0.06292541,0.08146769,0.070626065,-0.021183291,0.08123207,0.022367109,-0.017924992,-0.0069551063,-0.03999482,0.04453336,-0.028805178,0.099463925,-0.02261902,-0.0688775,-0.055661384,-0.03151839,-0.050702408,0.0006394455,0.025497343,-0.05753736,0.047344767,0.00027531275,0.030769043,-0.11320937,-0.0680435,0.018650109,-0.030141242,3.6575068e-34,0.07618561,-0.056287874,0.10101466,0.007109189,-0.055663213,-0.0030681002,0.0774277,0.02046836,0.023406582,0.0041982206,0.0350583,-0.0105334455,0.015140504,-0.066251345,-0.004752528,0.054859713,-0.009271968,-0.005652817,0.058509693,0.04026011,-0.003693155,0.011792269,0.016480174,0.09651126,0.053761203,0.075716525,0.01452238,-0.0019530556,-0.07552723,0.029911192,0.030482544,0.07004557,-0.04148779,-0.061042886,-0.052007284,-0.008271353,-0.09736277,-0.01278196,-0.0069765327,-0.020985939,0.016151197,0.05498444,0.06282519,-0.0045872508,0.010520141,0.042866427,0.027957102,0.024932979,-0.0021861685,-0.041766163,-0.009070528,0.099440955,-0.00797877,-0.04209437,0.04130011,0.01732226,-0.047809716,0.014699099,0.035344053,0.037282605,0.0067929225,-0.06915579,0.014899704,0.10745321,0.030028766,0.10507638,0.046958737,-0.016195957,0.036776062,0.07768746,0.059881773,0.040236715,0.05812127,0.105743006,-0.04496424,0.016713494,-0.05329847,0.07651241,0.00803724,0.014868353,-0.019268366,-0.016083399,-0.04608814,-0.091910556,0.043844398,-0.024019118,0.045906533,0.054757874,-0.007998638,-0.026156204,0.031497672,-0.009735406,-0.027109524,0.037469666,0.07564672,-1.9977723e-08,0.09066985,-0.047100395,0.021396253,-0.09606707,-0.0063670287,-0.0071035447,0.06365685,0.0046283896,0.061157417,-0.0008820098,0.024579087,-0.020273905,0.047039416,0.004775769,0.032485493,0.075822994,-0.01940812,-0.021913694,0.019391755,-0.07981513,-0.04740351,0.001936404,-0.10317189,0.00753118,0.07142017,0.010388294,0.004406259,0.008331364,0.0018802646,0.00193429,0.06103492,-0.033622324,-0.007979489,-0.078628175,-0.0016374547,0.089614056,-0.01480436,-0.025552817,-0.07120053,-0.016167747,-0.08352152,-0.0088831885,0.02011399,-0.038908735,-0.0075784125,0.06274982,-0.060978554,0.019942068,-0.035090562,-0.040864546,0.038964637,-0.0051312405,-0.07638949,-0.080362394,-0.15321009,0.04632519,0.039614286,-0.041317645,-0.012306477,-0.087682545,-0.037958488,-0.054651886,0.07941697,-0.07056297 +4.6.1.1,"Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.",384,1.0,-0.07818014,-0.0029120182,-0.016589474,0.017753843,0.033531576,0.021126693,-0.031119479,0.035786256,0.059904862,0.0740598,0.009789091,0.0269842,-0.06410407,0.039719377,-0.025764912,0.046874035,-0.07140045,0.00682544,0.07774647,-0.0057156757,0.04456238,0.055887077,0.02875174,-0.026647158,0.027800176,-0.0061804825,0.011111309,0.04954116,0.04889736,-0.032390825,-0.014843621,-0.00943508,-0.06400025,-0.10623716,0.03639084,0.108564235,-0.052724555,-0.020503389,-0.008289271,-0.0059385602,0.063503556,-0.026751377,-0.06782008,0.0068954336,0.015003962,0.0053216782,0.005058878,0.076035984,0.012620227,-0.04352344,-0.002700382,0.028442565,-0.004749968,-0.015321589,-0.02904517,0.008110052,-0.04531951,-0.025646346,-0.025087673,-0.08512122,-0.033230335,-0.04061081,-0.016551703,0.034402177,0.06673859,0.011873707,0.07576688,-0.021972785,0.0074550053,0.018975146,-0.11930132,-0.032905597,-0.00018947163,0.007986506,-5.073951e-05,-0.039963946,-0.062097732,-0.06434072,0.09706577,-0.04473555,0.017933073,0.017356995,-0.034900073,0.0071802046,-0.0015751121,0.011905869,0.002314021,-0.03398049,-0.0484432,0.05356862,0.044843215,-0.04139996,-0.06254682,0.08087493,-0.093670145,-0.0119509185,0.048394267,0.05159866,0.012493908,-0.035575558,-0.006961134,0.12619227,-0.060994804,0.0006280178,-0.002799848,0.027603844,0.0017396801,0.041194674,-0.04389402,0.04678876,-0.039173853,0.0049407342,-0.031648114,-0.03504735,-0.0006172225,0.100283444,-0.040570393,-0.054101504,-0.03178986,-0.060300563,0.021318931,-0.05311438,-0.025964392,0.044130612,-0.06594598,0.037510775,-0.058534753,1.1171519e-33,0.07771613,-0.0057886825,0.03236373,0.020348934,0.0075525674,0.04441135,-0.1481909,0.005641406,-0.0049794368,-0.018464798,-0.078549474,-0.1574658,0.10000973,0.0036149034,-0.04669261,-0.033150923,-0.0648133,-0.009144672,0.010336207,-0.05132694,0.008019074,0.09481198,0.004875839,0.033447612,-0.016270777,0.03950108,-0.03401254,0.051002678,0.012011118,0.0022130522,0.022964383,-0.0976493,-0.08217898,-0.022268564,0.024599962,0.03137492,-0.014271109,-0.06385258,0.04452699,0.09392259,-0.031334452,-0.012216286,0.0034794325,-0.008868085,0.058314495,-0.072122045,0.008848312,0.08156784,-0.0058587,0.04517343,0.09788573,-0.046852652,0.06773408,-0.06355215,-0.010079775,-0.02283627,-0.037979238,-0.07837823,-0.013264471,0.06986307,0.04192336,-0.027529133,0.009971483,0.026567006,-0.072860636,0.070584424,-0.095465265,-0.11122346,0.03225936,0.06683647,-0.030982893,0.010854972,0.13040066,-0.009262064,0.036423963,0.0015323441,-0.035089757,0.0387571,0.002555774,0.0680855,-0.08513233,-0.0835342,0.02312215,0.07273458,0.017501568,-0.027013306,0.02980796,-0.06079866,0.019369066,0.039466128,0.08662933,-0.014526459,-0.018090678,0.025517076,0.0139204515,-3.4424786e-33,0.09074026,-0.028652791,0.0022622882,-0.088354826,-0.03221837,0.07692738,0.008393751,-0.027145183,-0.017464977,-0.07647765,0.091961205,-0.012217355,-0.020322684,-0.027869605,0.07837459,-0.0062527317,0.0008786058,0.04538356,-0.03882973,0.029611282,0.07104029,0.060976982,0.02067365,0.053190786,0.05448593,-0.036824077,-0.033246886,-0.014024155,0.037379026,0.047246568,-0.04110856,-0.018792752,-0.109486766,0.029366622,0.019882057,0.04465073,-0.05023814,0.017294224,-0.058869384,-0.013429166,0.019136606,0.07533869,0.0010475931,0.050415616,0.083431184,0.0794835,-0.020745253,-0.01578913,-0.043367717,-0.041047394,0.06957563,0.0074950783,-0.024902182,0.058935013,0.06756203,0.046576213,0.008796123,0.029068958,0.05145262,0.037758786,-0.050106086,-0.045290973,0.02069039,-0.09082745,0.06301623,0.033428207,0.024729945,-0.0071405484,0.06840878,-0.023477633,0.04184503,0.047559023,-0.01677206,0.008102882,-0.017385798,-0.0042955372,-0.06562685,-0.053519905,-0.016695201,-0.057536535,-0.06563008,-0.007052405,0.027611462,-0.063306354,-0.061329093,-0.10494703,-0.020064745,0.042938717,0.017125228,0.07272316,0.0079426505,0.025864974,-0.05235591,0.03543782,0.016273808,-3.569142e-08,0.0034084383,0.016461404,0.04582878,-0.073051944,0.008216516,0.009350331,0.06522843,-0.008839761,0.05427788,-0.06474333,0.06901928,0.101960495,0.11868955,-0.016586553,0.06806595,0.0001054355,-0.058892112,0.038821027,-0.066224694,-0.10723164,-0.10561225,-0.049135774,-0.09598403,0.055332776,0.038088296,-0.051582605,0.028116722,0.032020822,0.06698196,-0.13301155,0.047960903,0.033884387,0.03051993,-0.060496267,-0.07723414,0.07655701,-0.0030659516,-0.011971159,-0.02283706,0.09207419,-0.11136471,-0.043158237,-0.03218549,0.0095163025,0.027251642,0.0441449,-0.031549435,0.004290178,-0.08754426,-0.03706627,0.03361102,-0.015515347,0.013454078,-0.05228961,-0.07755514,-0.013931302,-0.07041128,-0.06952971,0.041236382,-0.059064012,0.016008055,0.058889918,0.07514576,-0.028192716 +4.6.1.2,Also acts on ITP and dGTP.,384,1.0,-0.04280421,-0.051143896,0.09597604,-0.06327765,0.03382147,0.040132333,0.07622442,0.03677539,-0.037718207,0.017328128,-0.006042209,0.079001576,-0.09595162,0.08978425,0.033744104,-0.03447228,0.060781356,-0.028134087,0.090543136,-0.0323827,-0.05030644,-0.038284384,0.038156375,-0.04019003,0.012112397,-0.0014936026,-0.028471597,0.035511456,0.011381658,-0.0487935,-0.0034082097,0.024156552,-0.02960193,0.038340744,-0.054196447,0.049528684,0.03360803,0.04226472,-0.0455083,-0.046394557,0.1116863,0.015238826,0.0009331752,-0.015453019,-0.007140016,-0.0005585896,-0.052508533,0.039348353,-0.030808724,-0.02613228,0.04860912,0.028523719,0.045585986,0.037324127,-0.045256827,-0.04670779,0.02438558,0.037378553,0.010576331,-0.011580894,-0.081837,0.011220411,-0.036983646,0.049975764,0.057076886,0.12961842,-0.004372874,0.030496279,0.013956865,-0.020085393,-0.094570234,-0.016470691,-0.09211118,0.08262987,0.06160591,0.020478955,0.014676956,-0.039121367,0.06027962,-0.10707183,-0.029221023,0.043049198,0.0042038043,0.015154924,0.02824731,-0.021694677,-0.06365078,-0.047689166,-0.05052022,-0.0075328406,-0.0051490446,0.053294193,-0.06696305,0.0484038,-0.014332275,0.012726269,-0.013470075,-0.025066756,-0.08106065,0.024731027,-0.0199533,-0.028344894,-0.034797423,0.017309846,-0.061115805,-0.054097053,0.039762683,-0.06477108,-0.01434812,-0.0016277212,-0.008945365,-0.006238778,0.018891089,0.019161453,0.019213917,0.04795089,-0.11720051,0.06684542,0.0098418705,-0.058255523,-0.02177069,-0.061143946,-0.007814368,0.09472947,-0.062417623,0.021837298,-0.0066423095,-1.7222994e-33,0.0223834,-0.00042040795,-0.041973192,-0.035425656,0.015351502,0.03948006,-0.0009807372,0.05910685,-0.038008325,0.024295988,-0.110830314,-0.055336006,0.00996097,0.010095999,-0.016253762,-0.025926948,-0.035109304,0.09238696,-0.015789894,-0.028821005,0.07729692,0.08692331,-0.062144157,0.03176773,0.053059213,0.04325797,-0.057476856,0.01768415,0.082253315,0.009596972,0.04521764,-0.058048204,-0.013180693,0.061362002,0.021735692,0.10331885,-0.030657353,-0.054170836,-0.022519073,-0.01163171,0.03986608,-0.003908053,-0.06201259,-0.013936461,-0.0468579,0.011083878,-0.004687015,-0.046277307,-0.062356096,0.009987728,0.03305184,0.03553168,0.038751803,-0.07774206,-0.029660111,0.07825402,-0.0030560617,-0.05529967,0.10086447,0.07488421,0.062625535,0.08690467,-0.022956869,-0.012170471,-0.01041766,-0.021540798,0.032646596,-0.09378021,0.005273282,0.046725165,-0.067137286,0.05196435,0.121321954,-0.023850072,-0.021869527,-0.07004267,-0.052768834,0.0022271867,-0.019441394,0.07779459,-0.06765143,-0.10041955,0.021861646,-0.044753633,0.03073326,0.004762706,0.004218001,-0.11437886,-0.055525757,0.04459174,0.021154348,-0.014907794,-0.0032056556,0.08419534,0.059676964,-6.857784e-35,-0.12635669,-0.018213864,-0.031947978,0.040818766,0.023599641,0.013315468,0.046684787,-0.060178425,0.108812846,0.08587025,0.087436564,-0.0554289,-0.051593307,-0.033838425,0.064333946,-0.0043655587,0.04694717,0.067408875,-0.04816831,0.0048966426,0.013517862,0.03433752,0.019712899,0.10965178,-0.013457624,0.04775157,0.0059395325,0.04519639,0.017481051,0.019928433,0.06492057,0.10262787,-0.14096421,-0.05891252,-0.014989125,0.0021847654,-0.090676226,0.0552081,-0.06732149,-0.06548507,0.11078085,-0.009669174,0.008013397,0.1014746,-0.006948069,0.052957248,0.024492664,0.05513875,-0.09674948,0.020868674,-0.05309271,0.0071892864,0.024825709,0.035745673,0.02156535,0.08152396,0.11472341,-0.043682434,-0.04761898,0.008918017,0.02296272,-0.0034069146,-0.007421347,0.0050786273,0.07043195,0.016387526,-0.00622321,-0.03746606,0.057044577,0.026440656,0.026953219,-0.062151376,-0.036530234,-0.10442091,-0.12296263,0.014697568,-0.03670247,0.01788578,-0.014391176,-0.060143866,-0.043267753,-0.024299394,0.03609383,0.012445925,-0.06856744,-0.0031539898,0.0020129436,0.019593097,0.010897836,0.051587377,-0.08015314,-0.004626043,-0.033273406,-0.033233415,-0.059442375,-1.9171907e-08,-0.00031043243,0.0028272348,0.04881308,-0.0033284188,-0.016846396,0.016417576,0.06105663,0.04399447,0.040615406,0.010587881,0.03407098,-0.06809611,-0.020989472,-0.062465433,0.16068175,-0.088270456,0.029969739,0.049719933,-0.10209991,0.028011207,-0.065088205,-0.067273654,0.0350927,0.02249247,-0.03719077,0.014510013,0.020145865,-0.012806768,0.1411881,0.018532816,-0.009855699,-0.06181645,-0.06745492,-0.0053501576,-0.027375577,0.04149233,0.007311389,-0.057376977,0.01984802,0.04448347,-0.0068801926,-0.054848455,0.027668385,0.048237793,-0.03636017,0.04582873,0.036102336,-0.067547016,0.06323216,-0.032758288,0.012813318,-0.017843127,-0.0031206147,-0.05259217,-0.02261282,0.019069245,0.014644015,-0.05568373,-0.019856345,-0.025008759,-0.02451168,-0.07843074,0.044922955,0.03337207 +4.6.1.6,"In bacteria and archaea the enzyme's product, cCMP, functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.",384,1.0,-0.07621316,-0.029100016,-0.108073734,-0.0041859895,0.06511653,0.057491247,-0.0026920803,0.10414512,0.02805664,0.04238038,0.011073432,-0.08758845,-0.019523136,0.053432383,-0.017860837,0.030860564,-0.022053236,0.04651802,0.04841858,-0.062411766,-0.031992055,0.020751333,-0.0072956304,0.0018698922,-0.102477536,0.08758142,-0.0008360902,0.007487548,-0.004396516,0.00530122,0.023553992,-0.03993438,0.16758734,-0.0023014806,0.007520585,0.09746439,-0.039665036,-0.04865803,-0.0008954907,-0.0334503,0.014873804,0.05445502,0.004088115,-0.010265801,0.031906903,0.050858002,0.08267447,0.08422238,0.04317827,-0.0041802265,-0.0329171,0.0150545025,-0.058300115,0.04191949,-0.030697325,0.07365053,-0.11128563,-0.08296836,-0.002552672,-0.035469726,-0.015149088,0.04185124,0.045753285,0.059561282,0.070735216,-0.083328895,-0.0191618,0.01334348,0.050164986,-0.035266537,-0.07841678,-0.032152317,-0.044502426,0.0849653,0.021969294,0.0940552,0.048627164,-0.08608899,0.09024735,-0.04256343,0.015866674,-0.03474512,0.05592148,0.06576588,0.009905168,-0.01895449,0.039160486,-0.011396447,0.07749291,-0.06066515,0.084158644,0.01293416,-0.04917323,0.02232455,-0.08232733,-0.0015187907,0.050084554,0.021481263,0.019477393,0.026492907,-0.03399011,-0.03894666,-0.021986663,-0.1142361,0.010399254,-0.041211344,0.04817335,0.06514477,0.07357191,0.006920865,-0.027136518,0.017750083,0.011642744,-0.06191036,0.10824169,0.12003148,0.051347453,-0.028013814,-0.04832736,0.0032642956,-0.038537573,-0.09785774,-0.00020859335,0.037417766,-0.061794773,0.030050173,0.030863458,-6.431568e-34,-0.021055464,-0.022282608,0.047107078,0.010405229,0.03457051,0.010898774,0.016438322,-0.026514921,-0.065987475,-0.026784688,0.03794582,-0.03040275,0.058033764,0.10965574,-0.0122288875,-0.00029823286,-0.07772386,-0.031978723,0.065565124,-0.011303316,-0.002137909,0.039114736,0.024777763,0.06088464,0.084994934,0.04067082,0.02558883,0.030769493,0.05256678,-0.018718768,0.034844372,0.03578361,-0.12041825,0.014636346,-0.036600105,0.03935891,-0.06418468,-0.035698634,-0.069485754,0.04273933,0.0024968996,0.0057514645,-0.0027409154,-0.0019038159,0.022987386,-0.1314772,-0.121599585,0.029229393,0.051712267,0.008871587,0.06270057,0.012591427,0.03244666,-0.028985156,-0.03968961,0.005432118,-0.03817628,0.0021652128,-0.024108272,-0.014368803,0.0003786234,0.035816263,-0.046863746,0.010922297,-0.017013486,0.0006724739,0.021119772,-0.05902659,0.028593035,0.09429404,-0.033904202,-0.00172538,0.0036673108,-0.015007023,-0.022377148,0.008587518,-0.04546734,-0.023553103,0.01244136,-0.019008975,-0.09524814,-0.00042716865,0.06714565,0.056132175,-0.0677262,-0.07111764,-0.06049619,-0.022948677,-0.057476617,-0.029630655,0.1186273,0.043818057,-0.014672884,0.1088828,-0.08540181,-9.822213e-34,-0.03040117,-0.06685015,-0.053399563,-0.030348254,-0.1294053,0.056814827,0.0052360995,-0.09196784,0.045291167,-0.033095155,0.028405013,-0.045879204,0.020763991,0.02098486,0.096853055,0.04307475,0.029932734,0.025937505,-0.06520194,0.017838364,0.05089516,0.09723055,0.015492872,-0.013565079,0.019344851,0.0045474437,0.008217375,0.03747276,0.05282352,0.01158795,-0.00834657,0.0777613,-0.013312652,-0.0014147387,0.0057924236,-0.017388083,-0.008047181,-0.019948125,0.015265131,-0.022982944,0.024731772,0.049605202,-0.05675823,0.044109907,0.01151753,0.13767406,0.0582459,0.039725747,-0.011843202,0.0157283,0.009039168,-0.05911823,-0.04199057,-0.013678217,-0.0418562,0.06572806,-0.09613166,-0.0009912573,0.0384812,-0.05338469,-0.0017758408,-0.097381756,0.027567826,-0.07501947,-0.019739512,0.07183917,-0.02847537,0.045229103,0.03328608,-0.07080173,0.08992049,0.08156775,0.014609299,0.0026574195,-0.08236787,-0.028936354,-0.013050701,-0.07421433,-0.028002096,-0.013536592,-0.039944507,0.011875236,0.054757483,-0.05065945,0.0017297566,-0.022897527,-0.04572913,0.04079002,-0.011922143,0.064683974,-0.04437921,-0.03453368,-0.030825939,-0.013106554,0.0021886854,-2.9276793e-08,0.04148955,-0.04615931,0.0047090836,-0.061441258,-0.06556251,0.11432137,-0.04892223,-0.021174686,0.026894093,0.012282569,0.063110694,0.051382624,0.022509955,-0.00078726694,-0.0024183134,0.089585796,-0.073404185,-0.047096897,-0.06626972,-0.108956926,-0.08230748,-0.01289929,-0.07056542,0.07245851,0.00012925906,-0.031478185,0.016020525,0.0102495095,-0.03114149,-0.063413136,-0.03611831,0.03266889,0.047731306,0.033280306,0.016555559,0.057990868,0.019681437,-0.06687823,0.0051943217,0.042625416,0.027723594,-0.049523767,-0.075015984,-0.027418956,0.012124475,0.021852259,0.014430534,0.013537611,-0.017899321,-0.018764138,0.030757522,-0.027559051,-0.0151473135,-0.018757232,-0.08423673,-0.0018719969,-0.068447255,-0.10456964,0.017778674,-0.050291292,-0.01859409,0.0011867348,0.12471316,-0.07091822 +4.6.1.12,"The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).",384,1.0,-0.023264727,-0.095452696,-0.042601015,0.04829673,-0.024744617,-0.018620826,-0.06841959,0.011718195,0.006293106,-0.0005521686,0.05607731,-0.042242628,0.029901309,0.012310488,0.019916892,8.356341e-05,0.0071009337,0.05015041,0.053980958,-0.014753089,0.11504077,0.101570085,-0.0150408475,-0.07474023,0.015129399,0.036197398,0.06941834,0.004413943,0.05935763,-0.010312135,-0.10488651,0.03322971,-0.00013014866,-0.1162394,0.08679227,0.07245023,-0.08569162,0.01655955,0.034934584,-0.08072944,0.040370308,0.0058206054,0.088405944,-0.06083756,0.0009623991,-0.07840742,0.025989296,-0.051185217,-0.012445431,-0.009650173,-0.059756387,-0.020952506,-0.037595242,0.033813365,0.0030515492,-0.058786217,-0.0080057755,-0.06621315,-0.066081926,-0.036176354,0.006176376,-0.012416522,-0.009143832,-0.008377906,0.017940458,-0.00043153565,-0.0103065,0.03408342,0.016636988,-0.02812536,-0.032765653,-0.047448136,-0.035949912,0.032301214,-0.06672298,0.012324624,0.1252874,-0.0033779496,0.065386355,0.017163953,0.023754988,0.014708666,0.0669892,0.12709671,0.07018071,0.021285007,0.04037422,0.035406165,0.029986383,0.10936807,0.044588797,0.06434401,0.02487189,-0.030882102,0.0067235935,0.049927827,-0.032064795,-0.013074951,-0.014928477,-0.021128701,-0.016017351,0.060149554,-0.06337024,-0.009756876,-0.008310821,0.016766302,0.010555572,0.041673493,0.0030667577,0.0068281433,0.08710046,-0.009560762,0.011459885,0.015519002,-0.014139006,0.029760333,0.019131066,-0.124388866,-0.014470265,-0.01163719,0.02387852,-0.031121986,-0.046485584,0.073631555,-0.075147495,-0.0075112544,-0.0644075,3.3475464e-33,0.06505198,0.08588937,0.006194,-0.065159544,-0.011377887,0.04393682,-0.04345754,-0.023689931,-0.020330714,-0.020151194,-0.09959095,-0.09928468,0.018789917,-0.009024333,-0.019552154,-0.101152234,-0.01221423,0.07476158,0.12191356,-0.0028142852,-0.059024017,0.085430145,0.0034153126,-0.03644071,0.011385906,0.11020487,0.021421257,-0.05251909,0.034348216,-0.015064528,0.029475722,-0.10267121,-0.04372112,-0.023872925,0.12440995,-0.045371056,-0.04395637,-0.005093306,-0.04977597,0.04609867,-0.041352227,0.06824732,-0.07619693,0.03621982,0.056287352,-0.10936879,-0.012392323,0.027132425,0.009859256,0.07148635,0.0024467001,0.053505197,0.02638958,-0.047594946,-0.09273517,-0.010881511,0.006878777,0.07390103,-0.0063280715,0.022070045,-0.015823461,0.016808044,-0.013024932,0.044706125,-0.014539136,0.040652506,-0.10323896,-0.0915964,0.0042693233,0.0666208,-0.02643495,-0.04492553,0.0756083,0.0057361643,0.053222284,-0.0331529,-0.057463497,-0.0022743603,0.05481028,-0.015855828,-0.01673792,-0.021875406,-0.05076101,-0.04726141,-0.039723184,-0.009449388,-0.015835898,-0.012170713,0.023878142,0.008842014,0.09438547,-0.00081091205,-0.09213989,0.049614534,-0.008366846,-4.40496e-33,0.030920204,-0.043930754,0.050632965,-0.108576834,-0.10935829,0.009378771,-0.011445642,-0.08524109,0.0711622,0.01902538,0.07800921,0.0049208887,0.047299206,-0.07246738,-0.04088818,-0.0418532,0.02486269,0.09621888,-0.01861649,-0.061150078,0.0688216,0.06998401,-0.0034780002,0.045980528,-0.03446202,0.04663315,-0.016837658,0.0334858,-0.014195735,0.091695726,0.013942977,-0.004491948,-0.02172527,-0.021960964,-0.051024053,0.087698184,-0.018412527,0.016433008,0.038539574,0.060477406,0.014509562,0.0052754614,0.032479733,0.09276675,-0.019782895,0.0054275636,-0.11332477,0.02236423,0.072036736,-0.08647285,0.041283906,-0.044194315,-0.03378053,-0.047856312,0.015922947,-0.018142184,-0.0367479,-0.02249917,0.06287719,-0.05748935,-0.009476866,-0.07769135,0.04105782,-0.0723238,0.021372616,0.03232526,-0.00202077,0.013731638,0.034242768,0.033861015,0.0044638123,0.10056456,0.046087395,-0.045117877,0.028150192,-0.0035206766,-0.0284429,-0.08147438,0.038579054,-0.04876978,0.021035071,0.07725461,-0.02661193,-0.025912346,-0.014180307,-0.072209194,0.03380672,0.081479624,-0.006921179,0.042515088,-0.047489993,-0.033203833,-0.014245827,0.08189464,0.0037162176,-3.8675566e-08,-0.015328961,-0.090073034,0.0063619264,-0.033660777,0.0031434924,0.076542296,-0.033609033,-0.10236614,0.10636364,0.028915413,0.00512263,0.028218858,-0.041329283,0.013844648,0.07438248,0.014389378,0.00025202462,-0.020779666,-0.038227137,-0.100069866,-0.01467124,-0.036186963,-0.11585374,0.014544343,0.060618382,-0.06759579,-0.036942955,-0.025472902,-0.011639863,-0.0407355,-0.0027361612,0.0076755835,-0.050504997,-0.008199051,-0.085693695,0.078359015,-0.016131906,-0.03735913,-0.046283104,0.024615726,-0.035590902,0.015849998,-0.049162954,0.022330929,-0.05356639,0.03422892,-0.01578294,0.053256147,-0.087059736,0.005803769,0.032790974,-0.084629506,-0.02185055,-0.0096156215,-0.062677205,0.013436552,0.05380538,-0.027985336,-0.043860625,-0.027746525,0.045452304,0.049800906,0.14777832,-0.04389035 +4.6.1.13,"This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11, phosphoinositide phospholipase C.",384,1.0,-0.017956156,-0.09374676,-0.042548828,-0.016272435,0.06933151,0.055712152,-0.035499915,0.03421659,0.06736738,0.02483134,0.03807035,-0.067355774,-0.047545165,0.12221035,-0.003108354,0.028339282,-0.057521228,-0.033927288,0.0030561932,-0.044283763,0.049122997,0.049207825,0.01205922,0.031049628,0.008863003,0.0140750315,0.068471044,-0.05275384,-0.047011487,-0.033978775,-0.026479067,-0.04504819,0.1176297,-0.058298554,0.048444137,0.09357754,-0.067788444,-0.09872344,0.10520023,-0.0014710389,0.011678568,-0.034955524,0.05640351,-0.050482456,0.025892759,0.052709423,-0.0031289044,0.0074158413,0.10443226,-0.023658114,-0.023008255,-0.051674966,0.0022550917,0.060929287,-0.052326236,-0.024192456,-0.08781941,-0.007371613,-0.02263507,-0.00016610176,0.01500083,-0.0032635788,0.11913809,0.058036942,-0.0116771925,-0.016563226,-0.008802674,-0.08889788,0.013553135,-0.0629173,-0.025193326,-0.061514772,0.028076446,0.055607345,0.039160065,0.043226946,0.045074716,-0.03728602,0.019309696,-0.08856871,0.05771153,-0.02794072,0.0017643688,0.094383135,0.058196485,-0.0032735236,0.0012623643,-0.043990567,-0.010638297,0.050519116,0.016187679,-0.04018394,-0.014802845,-0.043900725,0.003825326,-0.004559695,-0.048036847,0.040735602,0.01872394,-0.05857448,-0.03669794,0.0499334,-0.032693636,-0.04728522,0.012732081,0.04752959,0.023040827,0.025240846,0.024301335,0.021044435,-0.005293091,-0.039096046,0.0049827355,-0.047383666,0.01879774,0.08681395,0.034597382,-0.07810235,-0.09015483,0.060136538,0.041462913,-0.12977798,0.065326974,0.031266876,-0.07924298,0.02175704,-0.084359445,3.3252784e-34,0.026778711,-0.019227069,-0.008967967,-0.08837565,0.0045034895,0.023501854,-0.024886863,0.0051110783,-0.03845613,-0.14205575,-0.061221022,-0.01910822,0.06368317,0.056906875,-0.0022364769,0.029407771,0.020001326,0.0033117696,0.05356695,-0.018333768,0.06274189,-0.050003655,-0.008999297,-0.012091928,0.039998706,-0.012668999,-0.07889194,0.003723076,0.034314893,-0.018242296,0.024254654,-0.09030399,-0.07202851,0.021438692,-0.0032488827,0.0009057531,-0.023458708,-0.071718566,-0.051575724,0.0019101538,-0.021040084,-0.024942975,0.010633848,-0.02124411,0.06761338,-0.03080429,-0.097461075,0.07448366,0.07292843,0.048872545,0.033222087,-0.024814913,0.12094739,-0.06253395,0.021342266,-0.011796592,0.004901844,-0.023922538,0.012769279,0.046224013,0.0008595847,0.096046105,-0.052692913,0.0077682226,-0.024456283,0.018091317,-0.07444566,-0.03444604,-0.045339245,0.04731369,-0.040776346,-0.012050326,0.015620135,-0.019199686,-0.014748387,-0.05427868,-0.046995673,-0.02823052,0.033261813,-0.0011583533,-0.0063979784,-0.058515977,0.05032308,0.032763004,-0.061092697,0.04176948,0.000579043,-0.039903358,-0.02038985,0.045961093,0.07687002,-0.0646831,-0.09969979,0.092822365,-0.009350879,-2.5904751e-33,0.07061013,-0.059714347,0.018600006,-0.06373285,-0.08337536,0.08081281,-0.026803197,0.04464805,0.10301992,0.046790853,0.028172666,-0.036808677,0.027419794,-0.051625617,0.059144426,0.058704935,-0.04341411,0.07585679,0.023362387,0.012662655,-0.020493347,0.05596756,0.032717787,0.041795205,0.05171645,-0.0011400922,-0.041083537,0.03447847,0.0007758565,-0.0016805659,-0.10329186,0.033953782,-0.047007143,-0.058972917,0.0028134366,-0.0030919025,-0.026561981,-0.09362633,0.05235126,-0.023901112,0.052588537,0.03809446,0.00791562,0.03087132,0.037847415,0.11576519,-0.046276428,0.100883774,-0.06543076,0.007926443,0.0006493156,-0.0072899754,0.034541167,0.032254416,0.06497341,0.10430158,-0.047346245,0.09057533,-0.019433212,-0.06652266,-0.03346414,-0.056740046,0.0008158022,0.050642107,0.05564014,0.024869315,-0.06391879,0.058864035,0.021867046,0.0030810433,0.032420974,0.036358364,-0.08112281,-0.015347746,-0.07017951,-0.0007229163,-0.08290096,-0.041981716,0.09891955,-0.024240537,0.03544586,0.011939919,0.05617209,-0.07284909,0.0032351187,-0.027491754,0.017878149,0.1072381,0.0031905922,0.058945045,-0.03267395,-0.035609707,-0.062599376,0.022232478,0.028816765,-3.427816e-08,0.071689315,-0.01017061,0.04382718,-0.063843824,0.07957163,-0.007651757,0.036695316,0.012968318,0.053792723,0.021581398,-0.036276404,0.02398033,0.0038162223,-0.05470896,0.07052554,0.0015545413,-0.048440505,-0.023237217,-0.010568673,0.017936243,-0.01260622,-0.044907726,-0.062869795,0.049923114,-0.004508292,-0.072378024,0.044436,0.05751624,-0.08853164,-0.03777798,-0.05910187,-0.018775458,-0.019919893,-0.04693636,-0.042132694,0.012154243,-0.024652595,-0.08653815,-0.08628132,0.08510104,0.0027390022,-0.044822697,-0.039515756,-0.048306026,0.015729945,0.0647061,0.0010843198,0.012254857,-0.016557252,-0.09935258,-0.012692555,-0.070516475,-0.021930056,-0.028780805,-0.10413405,-0.022993723,-0.011491641,-0.07902572,0.008227778,-0.061149843,0.025910715,0.06500904,0.18140087,0.034554876 +4.6.1.14,"This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors. In some cases, the long-chain acyl group at the sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group. In other cases, the diacylglycerol is replaced by ceramide (see Lip-1.4 and Lip-1.5 for definition). The only characterized enzyme with this specificity is from Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown. Substitution on O-2 of the inositol blocks action of this enzyme. It is not identical with EC 3.1.4.50, glycosylphosphatidylinositol phospholipase D.",384,1.0,-0.04949294,-0.10178097,-0.12582055,-0.034190275,0.03307517,-0.043372493,-0.056218483,-0.03095747,0.042270295,-0.0077338303,0.07010669,-0.044968404,-0.025910703,0.056717295,-0.079743676,0.023235299,0.055108275,-0.05989684,-0.030166656,0.003529195,0.0946683,0.08575363,0.05857224,0.043969363,-0.06628029,-0.06303518,0.017586594,0.01794328,-0.021843268,-0.0564241,0.015233584,-0.032866597,-0.013365264,-0.050158784,0.05429165,0.049334187,-0.03214709,0.06104289,0.032621123,0.012044025,0.05186801,-0.046264607,-0.05910224,0.015034531,-0.009243199,-0.055506717,-0.05776256,0.048005424,0.02952327,0.058888167,0.0011273216,-0.11354092,-0.040513072,0.015336419,0.015180462,0.021681195,-0.11346935,0.02004382,-0.005251296,0.025427075,0.041111857,0.04315543,0.03001055,0.028673247,-0.01870689,-0.0867898,-0.003363595,-0.09079718,0.016181292,-0.025630932,-0.030549964,-0.108501054,0.0016413912,0.07907007,0.02166958,0.028345494,0.03391719,0.007089412,0.036175255,-0.07528905,0.06260554,0.025952723,0.0651101,0.076549515,0.020860663,-0.017963197,0.039291147,0.047490068,0.07104151,-0.023776991,0.052898295,-0.04645553,-0.019706037,0.006810947,0.031374667,-0.017152717,-0.019226821,-0.0005330815,-0.000957215,-0.02494124,0.038087744,-0.06112204,0.013361822,-0.09118757,-0.052277323,0.050912403,0.017872754,0.05688243,0.031636335,-0.027380515,-0.026030477,0.025472732,0.0764442,-0.035385482,-0.04046007,0.028001366,-0.0571447,0.005112395,-0.0012504852,-0.0021363168,-0.011636947,-0.022747716,0.03838231,0.008802985,-0.027818155,0.10223942,-0.07745067,3.795527e-33,0.04278429,0.010048707,-0.01281479,-0.012608694,0.012892069,-0.056213316,-0.005811098,0.037716985,-0.12792942,0.00013177466,-0.024609193,-0.0107303215,0.0023706965,0.059543293,-0.01058714,0.017142417,0.0037343593,0.017744353,0.05763708,-0.002961269,-0.055617534,0.087240286,-0.029663835,-0.08055942,0.03433132,0.093072996,-0.057956986,-0.005188874,-0.019814594,-0.0003208207,-0.024470076,-0.060954753,-0.12019927,0.058248345,0.039000187,0.00917503,0.047526393,-0.061292745,-0.016797949,-0.015022325,-0.019101294,0.010939568,-0.009816478,-0.01886446,0.032186683,-0.023872733,-0.09722805,0.11256746,0.013514753,0.043144565,0.029782187,-0.004904891,0.10536037,0.03812344,-0.15637204,0.06336075,-0.035863794,0.027535498,0.057203796,0.0054867174,-0.01568415,0.06229019,-0.05470063,-0.03528497,0.033132542,0.022299282,-0.11223515,-0.069862545,-0.01930296,0.030966539,0.01732853,0.009536904,0.06307607,0.08504443,0.059549056,-0.04795547,0.0007914292,0.03698565,-0.025954058,0.051141437,0.012796361,-0.017511146,0.020113891,-0.02698338,-0.12700039,0.0246884,0.0023743045,-0.10063956,-0.039980475,0.002745868,-0.0059119593,-0.05599497,-0.064911306,0.08944762,0.022156917,-5.95329e-33,0.07507317,-0.07224982,0.10977932,-0.03781918,-0.015209074,0.03024485,-0.0025310358,-0.028411252,0.03467979,-0.025163507,0.097887665,-0.029674482,0.002981036,-0.023203766,-0.005620284,0.09506816,-0.09954967,0.004904398,-0.0050216583,-0.031318326,0.017186157,0.08883664,-0.078797564,0.041095182,0.0391235,0.016509654,0.018786242,0.0320354,-0.017216904,0.053072475,0.0007432319,0.005216118,-0.07951721,-0.017447473,-0.010055441,0.03257854,-0.06610101,-0.037286486,-0.02772734,0.02206493,0.0017276279,0.058551986,0.113148205,-0.00237259,0.059879243,0.058854725,-0.08287699,-0.0049452223,-0.019830521,-0.05559978,-0.01347538,0.028300067,0.027549947,0.081157394,0.062266633,0.12806384,0.028765319,0.015912844,-0.06410594,-0.091169976,-0.04931734,-0.02991465,0.003494864,0.049190674,0.09636175,0.05488622,-0.054671213,-0.048041306,0.036101718,0.013541936,0.03935958,-0.068722196,-0.005056898,0.015346996,-0.027363539,0.039009497,-0.018004635,-0.102712624,-0.05770014,-0.03626903,0.06707613,-0.041553114,0.070032574,-0.043922473,0.0020877148,0.011980429,0.01994958,0.07469449,-0.025340132,0.054681588,0.040600467,-0.02994929,-0.08151576,0.047239672,0.043928523,-5.8516214e-08,0.05880615,-0.058179855,-0.006682016,-0.092064396,-0.028223772,0.0019863856,0.037849315,-0.004570286,0.045410164,-0.03403818,-0.038746182,0.07824208,0.013085366,0.004830211,-0.034633394,0.06420221,-0.009179728,0.00859945,0.0104407985,-0.08474025,-0.06309775,0.0006508443,-0.042933192,0.014958592,-0.00912669,-0.07799029,-0.03067915,0.07738766,-0.034745123,-0.016534284,-0.06637463,0.012702418,-0.025080862,-0.018502513,0.056720078,0.09011466,-0.09452438,-0.05006365,-0.041104395,0.1072006,0.06503076,-0.0007926909,-0.008125108,-0.013154968,0.041690715,-0.05152332,0.010031279,-0.023599127,0.0143783055,0.017863555,0.018122034,0.042683445,-0.034355182,-0.07003575,-0.123859614,-0.008658292,-0.10910281,0.022133574,0.004920219,-0.009769472,0.020858508,0.035043247,0.13872734,-0.03660099 +4.6.1.15,"Requires Mn2+ or Co2+. While FAD was the best substrate tested [2], the enzyme also splits ribonucleoside diphosphate-X compounds in which X is an acyclic or cyclic monosaccharide or derivative bearing an X-OH group that is able to attack internally the proximal phosphorus with the geometry necessary to form a P=X product; either a five-atom monocyclic phosphodiester or a cis-bicyclic phosphodiester-pyranose fusion. The reaction is strongly inhibited by ADP or ATP but is unaffected by the presence of the product, cFMN.",384,0.99999994,-0.049351014,-0.0887663,-0.012291936,-0.035984803,0.11385527,-0.05682142,0.010012172,0.06295229,0.005764719,0.037601233,0.025264084,0.061059546,-0.03807453,0.09519182,-0.00042531424,0.060075667,-0.0482848,-0.011709343,0.048069328,0.018940428,0.08525665,-0.02447139,-0.0070597352,-0.039670933,0.020582026,0.015509377,0.02968043,-0.0067596147,0.008950592,-0.008069608,-0.039551497,-0.007242528,0.015178716,-0.04320891,0.0028550832,0.10396338,-0.009664577,0.011854424,-0.04252818,-0.02260388,0.057927962,-0.04188955,0.07616592,-0.068140805,-0.027398458,-0.047337122,0.0063939774,0.03978385,0.05484689,0.04743275,-0.038043346,-0.022086136,-0.033566386,-0.007931358,0.024365392,0.04656249,-0.098357454,-0.014628907,-0.036258556,-0.004733415,-0.014607223,-0.0076182764,-0.041895166,0.051095005,0.12811187,0.0026589327,-0.038263597,-0.02269716,0.015811028,0.050561167,0.04057653,-0.028291302,-0.06617401,-0.03390451,0.049598712,0.060992282,-0.020519076,-0.07536651,0.04301197,-0.02074271,0.032721516,0.04799774,0.066924475,0.027492926,0.05627078,0.01763536,0.0058398806,0.040754322,-0.03145529,-0.007317265,0.011588491,0.013118364,-0.010739979,-0.0027190887,-0.011336619,0.046750147,-0.001501106,-0.015518024,-0.043859646,0.0077879657,-0.008305295,0.07203034,-0.026354957,-0.05587002,-0.0531709,-0.013826943,-0.013237477,0.041867826,-0.015194072,0.053372294,0.012032119,0.031539325,0.0010916191,-0.05969178,-0.017131137,0.061517,0.0167924,-0.09731764,0.0055265455,0.010436032,-0.019702604,-0.012147913,0.01364146,0.083560824,0.02032381,0.07923349,-0.08996162,5.440808e-33,0.026636234,0.010755133,0.009694261,-0.050935976,0.044575572,-0.0063540214,-0.053416703,-0.05330438,0.00054568617,-0.011984308,-0.046896864,-0.11849995,0.07622897,0.020976674,0.006990359,-0.049530428,-0.016418958,0.005280176,0.08793296,-0.0061718863,0.033022247,0.009600347,-0.010108789,0.0614359,0.0092423605,-0.017153649,-0.024638839,0.096885785,0.03695879,-0.009641585,0.0024440233,-0.10156304,-0.088011995,0.031879645,-0.0041703787,0.025622996,-0.18529835,-0.07560226,-0.009699042,0.035134804,-0.00053297094,-0.041770954,-0.029664429,0.03689425,0.08754331,-0.10844381,-0.10722089,0.026016677,-0.051722545,0.038457137,0.08552071,-0.0058023497,0.010863673,0.007782489,-0.057277076,-0.028641736,-0.027313223,-0.03786034,0.024737375,0.030397242,0.025027033,0.011552627,-0.015561623,0.11693219,-0.05167042,0.06493813,-0.027813649,-0.12364916,-0.020986522,0.084837705,-0.02297535,-0.07240572,0.05645481,-0.025437849,0.026475377,-0.05258132,0.0414759,0.015558969,0.0031164973,0.06907061,0.029834945,-0.037779577,0.017476821,0.03266509,-0.08430907,-0.028968614,-0.019136934,-0.10116863,0.04141797,-0.0046319254,0.06787549,-0.065316245,-0.062771365,0.043535266,-0.00078748993,-6.248937e-33,0.040231247,-0.05192843,0.13571487,-0.089742966,-0.113364786,0.014901669,0.06896211,-0.05866941,0.056118064,-0.074335955,0.0518437,-0.019621985,-0.047192436,-0.025798803,-0.03339088,0.048131473,0.002224607,0.034475658,0.07987364,0.053995054,0.008167287,0.16094379,0.08327325,0.08073722,0.022687363,-0.05417353,-0.000468307,0.0013862164,0.05488617,0.022858148,-0.028682606,0.020825645,-0.05233342,-0.024958411,-0.050620794,0.010736803,-0.09408308,0.0078774365,0.021616587,0.03791782,0.01521662,0.048515346,0.023347253,0.06647897,0.0221118,0.014312808,-0.029763091,-0.051266633,-0.032334283,-0.074209474,-0.0101374565,0.035936948,-0.006782224,-0.004913007,0.03630908,0.03183677,0.038081642,0.07018742,0.020911342,-0.04740696,-0.047451526,-0.08771252,0.01784565,-0.016513783,0.07351839,0.088764384,-0.030671468,0.063588634,-0.026903119,0.05654404,0.030075615,0.09091489,-0.008210088,0.0886714,0.00763436,0.034122374,-0.07062987,0.037430722,-0.00019487219,0.014282048,-0.022153571,0.049214125,-0.10062863,-0.033932988,-0.014962487,-0.056898274,0.045729455,0.051578388,-0.03782682,-0.009388094,0.031909525,-0.020849876,0.018683178,-0.014896655,0.10534052,-5.0354632e-08,0.025272097,-0.03636608,0.011221989,-0.102636956,-0.01957046,0.0032279682,0.020271562,-0.09142713,0.04538144,-0.049395315,-0.056896098,0.08567435,0.0021682258,-0.012492341,0.066450156,-0.043135166,-0.05023579,0.04126116,-0.06855645,-0.08830242,-0.07444928,0.029823147,-0.10742452,0.06926637,-0.019421801,-0.008900356,0.082681306,0.01205232,-0.021114772,-0.02997611,-0.01810048,-0.0028171595,-0.03700887,-0.022519145,-0.05382952,0.091822766,-0.0034461403,-0.014092531,-0.05033317,0.008799134,-0.119471684,-0.047235344,0.04062669,-0.010756321,-0.012750969,0.011072822,0.0030833448,-0.00043004382,-0.033086006,0.00735107,0.07180873,-0.018943334,-0.019395277,-0.14917877,-0.07234479,0.0032983036,-0.049784057,-0.08051478,-0.04176938,-0.0346267,0.044308614,0.005277298,0.13222703,-0.029931253 +4.99.1.1,The enzyme catalyses the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria.,384,1.0,-0.09096,0.014562136,-0.06956203,0.0021073287,0.015984356,0.034968298,-0.08325118,0.086953424,0.045785073,0.0300055,-0.0020213937,-0.07316039,-0.034103874,0.01124947,-0.03351241,0.015700573,-0.10783721,0.042703383,-0.051912177,-0.086639956,0.07558591,0.07551999,-0.06300811,0.009069043,0.019247469,-0.053919252,0.10309194,-0.046407387,-0.02106154,-0.07482473,-0.014907074,-0.05691972,0.09593324,-0.061021604,0.08785721,0.052892547,0.041887682,-0.103337094,0.076865144,-0.028356088,0.083849564,-0.013779849,-0.07409256,-0.034303777,-0.058610216,0.06376555,0.10585972,-0.034089524,-0.004645282,-0.019230844,-0.038315333,0.012342828,-0.09519867,0.0120495325,-0.0010762082,0.02485359,0.049613643,0.019380484,0.067910984,-0.03643015,-0.0022581867,-0.033650286,-0.034458727,0.0028091676,-0.036143947,-0.10811218,0.051977415,0.011040598,-0.07338366,0.0033950163,-0.034367174,-0.07725869,-0.05268148,0.024058696,-0.049363047,0.077352144,0.01164589,-0.006617052,-0.015501636,-0.004259023,0.038618032,0.009277951,0.07092364,0.12391153,-0.0052312477,-0.016086627,-0.0067551797,-0.006004467,0.06628226,0.049843848,-0.024299465,-0.04338804,0.028191762,-0.07712604,-0.0439412,0.045402396,0.047912885,0.059875462,0.06764397,-0.021627266,0.0022707833,0.05316208,0.016225511,-0.024986062,-0.0009509918,-0.017917993,0.017993718,0.10826065,0.10701351,-0.008033134,0.02521558,-0.015882414,0.09700831,-0.026702404,-0.08343246,0.06431531,0.02500528,-0.036816616,-0.04584965,0.009857094,-0.010373558,0.021889234,0.0539181,0.044539526,-0.04482357,0.0067921863,-0.097678475,-7.751075e-34,0.062969744,0.04761672,0.01583553,-0.054840773,-0.03282232,-0.035269592,-0.1301317,-0.026667682,-0.012023434,0.025399907,-0.02216278,-0.10669214,0.048262477,-0.043616652,-0.038462587,-0.013159872,0.002663442,-0.029472277,-0.02516451,0.05902933,-0.01644222,-0.060204726,-0.012498025,-0.036501706,0.03691027,0.04261262,0.040749077,-0.026626771,0.010298436,-0.010828166,-0.05368676,-0.059831694,-0.042520158,-0.041524492,0.08108279,-0.03898391,-0.017332125,-0.0025168923,-0.036769107,0.021906294,-0.007567682,0.09463409,-0.03757363,-0.0833698,0.070631355,-0.027073901,-0.0022679234,0.020242902,0.038092244,0.1397536,-0.010955987,-0.023341946,0.13684285,0.02001085,-0.025442732,-0.01877375,-0.036014833,0.0012715961,0.09384938,0.024192961,0.040603146,0.05095246,-0.05518509,0.013527706,0.045435984,0.03875538,-0.052203692,-0.017126113,0.029737769,0.04667361,-0.081392534,-0.012915966,0.036953386,-0.020002408,-0.005901713,-0.04147178,-0.06745121,-0.018210689,0.06308032,-0.04239133,0.012089681,-0.011556523,0.00918571,-0.043381516,0.031363655,-0.020864056,-0.06516046,-0.011267018,-0.10233432,0.011247712,0.084436126,-0.102863185,-0.0560582,0.058601703,-0.011906841,-1.2426831e-33,0.11312632,-0.044274986,-0.014787869,-0.12375726,-0.041544747,0.05218571,-0.021533147,-0.0023707952,-0.014848207,0.03119185,0.054993533,0.052617252,-0.03260196,0.0352976,0.010706269,-0.027624162,0.069427855,0.06642962,-0.022240581,-0.010314551,0.019791435,0.038327906,-0.031209419,-0.013939407,0.03557414,-0.022849614,-0.018939765,0.118769296,-0.001605111,0.051443234,0.01269356,0.026191266,-0.04915606,-0.03721932,-0.030561192,0.031993974,0.0064916853,0.06172147,0.08311986,-0.03960259,0.015621939,-0.0023401133,0.058455743,0.053752765,0.0077634696,0.0762364,-0.08234199,0.0634239,-0.033982925,-0.035316743,-0.0037612107,0.02785919,-0.018138073,-0.01001507,-0.021131808,-0.040747676,0.03766166,0.01760093,-0.051177178,-0.04647407,-0.07063228,-0.005968961,0.07612011,-0.0027021503,-0.015952084,0.061436724,-0.06837256,0.060513068,0.032375354,-0.034466665,0.020499695,0.057423413,0.010147828,0.00095255,0.03399174,-0.04658104,-0.020046758,-0.07578874,0.088469006,-0.015137401,-0.051563874,0.013069974,-0.018835338,-0.1219523,-0.0017682982,-0.055885028,-0.020024395,0.08373504,-0.029953124,-0.00073355116,-0.039987758,-0.058017954,0.031018589,0.06289482,0.029980816,-2.5466138e-08,-0.058034975,-0.07170122,0.023763403,0.005324239,0.0076556173,0.06928634,-0.018381396,0.082902774,0.061920345,0.010661112,0.032317024,0.038622368,-0.012211854,0.00124648,0.04089681,0.08694163,-0.041650467,0.001666904,-0.01130881,0.0041342047,-0.0048032627,0.0047122748,-0.06010788,0.08636965,0.0657414,-0.13169053,0.00072527205,-0.027646793,-0.0061962423,-0.05133399,0.01114268,0.046096344,-0.034696486,-0.0022609478,-0.029924527,-0.050661046,-0.006237978,-0.0021289391,0.04060638,-0.04106086,0.05076515,0.009818773,-0.1106451,-0.030892536,-0.00957858,0.10588241,0.025678195,0.06394441,-0.0672878,-0.069164954,0.044731442,-0.010621844,0.014216253,0.002249761,-0.09062412,-0.02671124,0.027344715,-0.06401379,-0.010058665,0.004480075,0.047343172,0.018707842,0.14859404,-0.056167208 +4.99.1.2,"Acts on CH3Hg+ and a number of other alkylmercury compounds, in the presence of cysteine or other thiols, liberating mercury as a mercaptide. ",384,1.0,0.065189295,-0.006346678,-0.00754511,0.025635544,0.19479674,0.040684517,0.044009343,0.011340724,0.05816884,-0.024826571,0.023286058,-0.095565364,-0.07701817,-0.033911753,-0.03584372,0.012785728,-0.055736672,0.027162652,-0.0021510597,0.08597977,0.0061316104,-0.0135518275,0.0075883507,0.043194838,-0.07198617,0.0811821,-0.018548686,0.06277549,0.052170634,-0.019857226,-0.046903703,-0.023444423,0.027447129,-0.03896103,-0.01455835,0.0629485,-0.052166987,-0.01909138,-0.0724064,-0.0809007,0.06580578,-0.060234316,0.014588359,0.028867316,-0.077771746,-0.06438459,0.039011467,-0.00973891,-0.027298192,0.010028053,0.024806669,-0.0205525,-0.0696553,0.06681784,-0.06966217,0.025022924,-0.12284848,0.0041307593,0.02092832,-0.0672489,-0.041969173,0.049152285,-0.029817333,-0.02732664,0.07462516,-0.016885402,0.0058892425,-0.021222683,-0.0050682463,-0.016999241,0.004232632,-0.053146347,-0.041810658,0.055421013,0.026314428,0.05597108,0.027443448,-0.10638141,0.004454374,0.008222877,-0.04754698,0.027096407,-0.02483323,0.07868862,0.035435025,-0.03971256,-0.04235213,-0.025865905,-0.04246891,0.0021478322,0.002380707,0.035655554,-0.036217127,-0.050729096,-0.050476503,0.07787785,0.07721825,0.058365446,0.08781469,0.0020921032,-0.013120256,0.0853836,-0.12155896,-0.13372421,-0.037354887,0.034100838,-0.018880427,0.011433209,-0.0674509,-0.032109916,-0.043470174,-0.027788172,-0.016195323,-0.028023407,0.012518825,0.13174312,0.05344438,-0.056137666,-0.09931013,-0.029793436,-0.024058448,0.0036417504,0.026349487,-0.0038603116,-0.0052405572,-0.0032961664,-0.040193576,5.7252e-34,0.02669263,-0.04013872,0.041377947,-0.007935915,0.08479156,-0.033618204,-0.06509675,0.043580394,0.015153017,0.030843465,0.011815549,-0.059144992,0.036798917,-0.072825044,-0.023114916,-0.034921214,-0.018779285,-0.02084346,0.020583961,-0.102311,-0.042324096,0.033039317,-0.026063437,0.038380746,-0.040327765,0.051371798,0.04390394,-0.030694598,0.09491278,0.0030222828,-0.008271193,0.04081157,-0.115488395,-0.029631123,0.024809334,0.091803744,-0.08701307,0.015427026,-0.018451102,0.014932634,0.025030525,0.039174348,-0.008333711,-0.06579652,-0.008503,-0.044268038,-0.08515253,0.019516625,0.046103828,0.03249859,0.04652075,-0.0910619,0.011220319,0.01772809,-0.08436991,0.039902944,0.012870113,-0.018647516,-0.08849141,0.034979586,0.013858046,-0.016230106,-0.012145154,0.061720453,0.06557507,0.039575618,-0.057992447,-0.021700744,-0.023529451,0.01967665,-0.0873996,0.00016624076,0.08388779,-0.0009165928,0.008056754,0.025522443,-0.08457129,-0.018510971,0.085477754,0.039528977,-0.050566733,0.01157417,0.053817477,0.009837371,-0.06364178,-0.03576852,-0.05043061,0.025144512,-0.0015638731,0.027091358,0.019529419,-0.09229483,0.04289586,-0.06062764,-0.09825411,-4.2165063e-33,-0.022601487,-0.03310739,0.0047041327,-0.014263355,0.013109095,0.067027405,-0.09000501,-0.0038424071,-0.049523827,-0.06871242,0.09283128,-0.028745059,-0.022882067,-0.009371833,-0.016255202,0.065651916,0.04408668,0.04750765,-0.049514804,-0.010399852,0.01598026,-0.017450653,0.050664432,0.05685524,0.047680955,-0.01930532,0.019225534,-0.0060436255,0.11314213,0.08627914,-0.037657354,0.07563892,-0.006029042,-0.08037218,-0.0053841304,0.0034998336,0.0043411264,0.016944947,0.015207273,0.09547322,-0.015608769,-0.0911895,0.061511625,0.0778365,0.04053525,0.061564635,-0.080767006,0.012105441,-0.0076908055,0.024368465,0.03399794,-0.045394517,-0.044059116,0.06235372,0.034526,0.10918288,-0.01660433,-0.01807069,0.00014547641,-0.034739744,-0.024887633,0.06644359,-0.07853604,-0.11148806,-0.02757184,-0.041877728,-0.104941815,-0.03873172,0.019176863,0.008500969,0.0918008,0.015081704,0.04054689,-0.02176442,-0.030353006,-0.106705226,0.053320356,-0.009405763,-0.031530235,-0.053620648,-0.0049205227,0.054199852,0.057296988,-0.015708372,-0.0074205347,-0.04901347,0.008023502,0.071210645,-0.075207,0.0110442275,-0.061368234,0.01801175,-0.037277345,0.10602122,0.009895065,-3.0552332e-08,-0.034953095,-0.029085515,-0.018172245,-0.002074153,-0.021006303,0.15282577,-0.0013956155,0.06222236,-0.033376835,0.019729385,0.032873172,0.032731578,0.043537147,-0.0048000948,-0.013086619,0.0061541316,0.030762598,0.037224635,-0.044072945,-0.06365826,-0.09247925,0.0056202714,0.016301043,0.024744937,-0.0036070962,-0.024554024,0.016968356,0.010013168,-0.038573697,0.0044847275,0.035704374,0.05314983,-0.016583776,-0.009322401,0.019818395,0.08239123,-0.031908926,-0.08441174,-0.015703687,-0.011745163,0.053581428,0.06865769,-0.15617451,0.035739835,0.033498913,-0.016930653,-0.044221077,0.1003855,-0.016322026,0.037445992,0.021023108,-0.05460083,0.009669618,-0.041543063,-0.025398139,0.034272853,0.046853624,-0.018172748,0.0072376803,-0.064954825,0.08661289,-0.026576735,0.07965405,0.030283498 +4.99.1.3,"This enzyme, which forms part of the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway, is an ATP-independent type II chelatase. Two distinct forms are known - a primordial form named CbiX, which is most common in archaea, and a strictly bacterial form named CbiK. See EC 6.6.1.2, cobaltochelatase, for the cobaltochelatase that participates in the aerobic cobalamin biosynthesis pathway.",384,1.0,-0.07061125,0.016104078,-0.12999561,0.007321463,0.02732569,0.016162073,-0.07540573,0.032252528,0.05786633,-0.082049474,-0.06640513,-0.12061956,0.033499926,0.005091428,-0.0011699521,-0.0044087586,-0.09003388,-0.04144496,0.012392075,-0.021802813,-0.021553379,0.04148589,0.0074242754,0.04548571,0.006104677,-0.007163921,0.05721292,-0.02491962,0.012142168,-0.0051027276,-0.043078884,0.011781336,0.08391694,-0.021600742,0.030733136,0.064953074,-0.053066067,0.029449428,0.035917725,-0.019022163,0.048776787,0.076067336,0.030787196,0.012307861,0.03313335,0.013465901,0.02369511,-0.010435948,-0.0018998218,0.017392289,-0.08130946,-0.04226962,-0.07195432,0.052235693,0.025153784,-0.00471645,-0.08098432,-0.05082058,0.086889476,-0.03168963,0.050222423,-0.05445499,0.015178039,-0.00597263,0.023451643,0.0049019945,0.02085497,-0.032305546,0.0623904,-0.08823189,-0.022268275,-0.05429518,-0.062333815,-0.0021616467,-0.045662936,0.10131729,0.008880447,-0.038521912,-0.043907456,-0.0503531,-0.022137245,0.024912,0.008514486,0.010332645,0.04111033,0.0053113136,0.03790118,-0.008539801,0.018596679,-0.0064097713,-0.032581892,0.030917816,0.08201019,-0.036049634,-0.10383026,0.0051746727,0.08328977,0.10846664,0.060771123,-0.025329672,0.059327137,0.06463722,-0.004560314,-0.0024705674,0.0077278246,-0.043715198,0.07685671,0.11973253,0.045486823,0.04803995,-0.010384189,0.016240114,0.01902772,0.012983082,0.058000106,0.11560436,0.010088544,-0.008036278,-0.06660354,0.110637486,0.02346375,-0.05990315,-0.018525857,-0.03393012,0.004715046,-0.016435431,-0.05124231,1.6195223e-33,0.06452601,0.033694435,0.015258922,0.0092604775,0.016219012,-0.003852665,-0.14136928,-0.012173493,-0.015827723,-0.047247294,-0.028028568,-0.027963128,0.008807098,0.01443222,-0.078945294,-0.047691677,-0.083172314,-0.038098235,0.026014697,0.020012107,-0.0013946997,0.09409812,-0.025305036,0.020561442,0.02806641,0.02715872,0.047894556,-0.009898246,0.01155656,-0.0034704034,0.05355553,-0.10928699,-0.12112581,-0.016259365,0.04201442,-0.019098561,-0.050002135,0.02682885,-0.05284011,0.03219653,-0.02032613,0.0006092487,-0.08075942,-0.024248496,0.06829423,-0.08331663,-0.033978578,0.087152354,0.024463309,0.021751046,-0.029591434,0.009355468,0.116600834,-0.047342014,-0.025824357,0.02367021,0.028998796,0.05361204,-0.0047490066,0.055343546,0.06314935,0.06796149,-0.049850494,0.10906706,-0.037087042,0.004449251,-0.052991174,-0.046020165,0.05053494,0.0055050533,-0.023596233,-0.03176346,0.023400323,0.04424493,0.035140917,-0.04213656,-0.090722054,-0.11317372,-0.024137275,-0.0037126653,-0.07880666,-0.03873622,0.01952973,0.0051892926,-0.07284877,-0.0070152003,-0.032265928,-0.022603933,-0.033019174,-0.012399452,0.018558456,0.031476296,-0.056640655,0.04072853,0.029679824,-1.7317456e-33,0.072738744,-0.08410728,0.06907207,-0.1608016,-0.052527912,0.061472606,0.016890926,-0.08772963,0.0658691,-0.0032864928,0.086515315,0.014496585,0.0519965,-0.012590841,-0.0044603287,-0.029950684,0.0219471,0.09475259,-0.01770734,-0.01963584,-0.0029040382,0.018567257,-0.033613242,-0.020152548,0.006700358,0.11784577,-0.01581077,0.11948798,0.053801402,0.06791888,-0.058066744,0.10344061,0.02333643,-0.034677736,-0.037335113,0.026583174,-0.007719721,0.016792385,-0.027886823,-0.01961809,-0.050263114,0.032686546,-0.016297627,0.051089343,0.08087248,0.018467441,0.029477747,0.064368725,0.010723409,0.0353773,0.010143995,-0.017202055,-0.095092155,0.018237935,0.09170242,0.03228795,-0.031457726,0.05242477,0.016627502,-0.07573232,-0.037289053,0.0061173043,0.060142145,-0.020251254,0.038156584,0.027116152,0.007638457,0.016165815,0.056659754,0.05319538,0.07333123,0.105088666,-0.007871784,-0.013791474,-0.045259863,0.052166574,0.029558003,-0.06597667,-0.057420682,-0.09127878,-0.07061733,0.019347886,0.07223781,-0.04024855,-0.07894563,-0.07729333,0.002641892,0.016252648,-0.0018900144,0.045397714,-0.046296213,-0.051099554,-0.03556878,0.020948794,-0.0076819644,-3.657272e-08,0.02180542,-0.048134353,0.016692039,0.0009242879,0.035231695,0.025327675,-0.052611407,-0.06863369,0.10314122,-0.01227388,0.00916685,0.022656918,0.067484476,-0.041292462,0.013984981,0.033937544,-0.0070830532,0.003308114,-0.032931346,0.020793218,-0.026307441,-0.04766358,-0.041696735,0.053921193,0.019010931,-0.08772498,-0.0429463,0.01565746,-0.0042353715,-0.031611573,-0.006120726,0.038949396,0.07038126,-0.046204895,-0.065642945,0.004687272,0.015670229,0.0045710574,-0.035101905,-0.03027566,0.0022300796,-0.09454492,-0.118422285,0.0035052353,0.048330747,0.027623046,-0.011873406,0.039835546,0.0034348648,-0.06258158,-0.0020706158,-0.0580375,0.051084448,-0.04693972,-0.0141219795,0.09006343,-0.036299873,-0.049014304,0.015556755,-0.028273499,-0.023253242,-0.0011809894,0.17968367,-0.12820089 +4.99.1.4,"This enzyme catalyses the third of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107, uroporphyrin-III C-methyltransferase) and the second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76, precorrin-2 dehydrogenase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction.",384,0.99999994,-0.11255394,-0.05035651,-0.048653167,-0.04374062,0.043201394,0.04195162,-0.14420743,0.019944832,0.052943643,0.024993422,-0.047137823,-0.036529243,-0.09281752,0.019263608,-0.04965383,0.06640081,-0.13025376,0.018224537,-0.029206917,-0.058534734,0.1532045,0.043053027,0.015064142,-0.047841758,0.06226885,-0.06594561,0.038856674,0.039401207,0.031461235,-0.060719747,0.08230382,-0.018780645,0.013276009,-0.051601563,0.024326092,0.10907341,0.063967355,-0.013898381,0.048302323,-0.010698975,0.015712516,-0.023891164,-0.05921641,0.019071113,-0.008393395,0.03559314,-0.041401364,0.068934634,0.02261038,-0.09325125,-0.018814865,-0.0093104,0.0131516745,-0.031854086,0.0015383128,0.03274197,-0.009466114,-0.08096543,0.032420546,-0.04187251,-0.05027852,-0.07388803,-0.008760081,-0.0030486537,0.041810635,-0.032199226,-0.00522626,-0.11631493,0.07406089,0.01702059,-0.07755019,-0.051142182,-0.048414458,0.00022934152,-0.041287012,0.04741556,-0.003467931,-0.024207478,-0.0053257067,-0.055233177,0.07155629,0.029876806,0.07672726,0.067940675,0.0708451,-0.0441985,-0.030870799,0.0063473494,-0.034376305,-0.02194267,0.009779844,0.028536841,0.024750132,-0.00814989,-0.029133096,0.06597238,0.008317857,0.020004585,0.02635571,-0.02062858,0.088125445,0.037107166,-0.060090095,-0.08989311,0.024565889,0.022939865,0.014419437,0.16466662,0.0511538,0.036047727,0.0025965471,0.0074557527,0.031878617,0.025948374,-0.09218963,0.0897924,0.019547105,0.006757036,-0.020928018,-0.058201253,0.005603674,0.049363583,0.012642025,0.040345848,-0.10129957,0.003286202,-0.07444451,5.313337e-33,0.077826396,0.045810133,-0.06876617,-0.004057272,-0.05507054,0.016583366,-0.027186556,0.033251293,-0.010599078,-0.08244502,-0.035583485,-0.07354272,-0.027358467,-0.01602812,-0.06846394,-0.033215955,-0.0051104096,0.020958338,0.031731084,-0.029129343,0.00056372175,0.07830285,-0.011004738,0.0066400454,0.039714336,0.056278948,0.021585241,0.023608673,0.024561405,-0.018158713,0.008066992,-0.06653949,-0.07817291,0.031539194,0.028057659,0.002367977,-0.031493522,-0.034619212,0.012913662,0.06712709,-0.12671149,-0.00059046404,-0.024041029,-0.0934556,0.030931352,-0.06034743,-0.06258487,0.020775978,-0.0016414837,0.03429218,-0.05381398,-0.041208982,0.11055348,0.0052474197,-0.026225492,-0.0630381,0.008698941,-0.024125176,0.013759537,0.05894068,0.009239061,0.09226601,-0.01440074,0.1362805,-0.041058373,-0.034929674,-0.022701537,-0.051314298,0.020618463,0.1312505,-0.02029222,0.06734224,0.06480328,0.005303278,0.056978997,-0.030340493,-0.032242257,0.041208323,-0.001913075,0.052488156,0.036593806,0.021777356,-0.034725625,-0.0075767073,-0.018014258,-0.019985024,-0.018749833,-0.10633477,-0.046886716,0.006773091,0.02761932,-0.09611547,-0.029149672,0.034069333,-0.021544017,-6.6088945e-33,0.15455632,-0.009392135,0.14226602,-0.09427858,-0.08830935,0.1160156,0.017040761,-0.10748296,-0.004559649,-0.057027888,0.03304096,-0.017962193,0.08994283,-0.08861124,0.002042522,-0.030295415,0.046624035,0.06002787,-0.030063134,0.03283323,0.025312798,0.100026414,-0.041828137,0.07078011,0.031423938,-0.043787844,0.045193903,0.014639411,0.034894224,0.03536202,0.008653447,0.02781248,-0.06696859,-0.020854434,0.0013609617,0.076260574,-0.060293704,0.034282845,0.018035563,0.029853562,0.023668276,0.031094648,-0.042823706,-0.011656938,0.057578593,0.0256181,-0.11838162,0.01006778,-0.035413466,-0.08019395,-0.0014995838,-0.011640249,-0.047428876,0.006824805,0.023701617,-0.004362412,0.039310932,-0.0037222635,0.0047167833,-0.014661715,-0.036104027,-0.03260721,0.03745047,-0.029294739,-0.0042231176,0.08487442,-0.005088034,0.04841222,0.032551594,0.020767406,0.001601375,-0.028056132,0.060261656,0.023644509,-0.006186735,-0.0026327907,-0.07126373,-0.055823933,-0.01764593,-0.063038155,-0.008535169,-0.011396997,0.02751354,-0.04682904,-0.011668625,-0.07293891,0.07554372,0.08647852,-0.03476596,-4.877834e-05,-0.013059746,0.09624753,-0.045503005,0.05795452,0.076336496,-4.952128e-08,0.09840759,-0.046640396,0.019123454,-0.06728793,0.0076984516,0.053674303,-0.004255632,0.02310441,0.03692651,0.009780734,-0.022838788,0.06479132,0.04129104,-0.037128992,0.02493404,0.007525961,-0.06893338,-0.0027533974,0.041859496,-0.028185101,-0.017006427,0.0018534372,-0.08264456,0.0050073974,0.020404272,-0.07012112,0.035032924,0.031396654,0.023597367,0.02832054,0.033176836,0.036743507,-0.040566996,0.020241572,-0.01137921,0.065122455,-0.036085702,-0.027969964,0.03353843,0.011726965,-0.018424788,0.013461933,-0.05140508,0.05896197,-0.01625049,-0.019462826,-0.03621662,0.022473969,-0.027818037,0.018395372,0.02721995,-0.03883288,0.033409383,-0.058260236,-0.072789066,0.028546024,-0.07003441,-0.11497954,-0.008359797,-0.03107349,0.05630646,-0.025672497,0.08358056,-0.053520482 +4.99.1.5,"The enzyme from Pseudomonas chlororaphis contains Ca2+ and protoheme IX, the iron of which must be in the form Fe(II) for activity. The enzyme exhibits a strong preference for aliphatic aldoximes, such as butyraldoxime and acetaldoxime, over aromatic aldoximes, such as pyridine-2-aldoxime, which is a poor substrate. No activity was found with the aromatic aldoximes benzaldoxime and pyridine-4-aldoxime.",384,1.0,-0.0012618828,-0.06551153,-0.046218432,0.07525453,0.078888126,0.07043593,-0.028819567,0.014331824,-0.0041163745,-0.05135888,0.009933007,-0.08201551,-0.003489378,0.08690102,-0.056812435,-0.01808737,-0.036045358,-0.0040935655,0.04828785,0.07286376,0.033805966,0.012517625,-0.048142854,0.016648568,-0.01941193,0.079533264,0.05522799,-0.014489744,-0.0122748595,-0.031960133,-0.09858132,-0.030875254,0.11254664,-0.087360516,0.03038673,0.0864525,-0.05571883,-0.026493032,0.051848616,-0.0025456108,-0.021649987,-0.006876582,-0.029715592,-0.017504595,-0.019611862,-0.050666884,0.115606576,-0.05655926,0.08235411,0.03690841,-0.047839012,0.015981171,0.016298689,0.095324606,-0.015654605,0.02147529,0.027592894,-0.013109389,-0.0512982,0.0032901631,0.028041894,-0.04139585,-0.04006979,-0.0183336,-0.02531831,0.0167801,0.041548442,-0.0020068656,0.015557815,-0.0733101,-0.008161655,0.0044995807,-0.023503061,-0.010256673,0.037775405,-0.0069279717,0.035799406,-0.12636627,0.011589871,-0.048751954,-0.010315377,-0.0058815833,0.046887927,0.07509539,0.084665485,0.04405248,-0.018173475,-0.0032934465,0.010288654,0.017129114,0.026757548,0.04603043,-0.061194874,-0.036828164,0.022184776,0.082614765,0.007083429,0.046110082,0.008272276,-0.05356797,0.010334059,0.031090187,-0.0670782,-0.08162688,0.056613576,0.05641928,-0.027058559,0.0713242,0.0046581854,0.026948571,0.047081407,-0.0011439576,0.030988399,-0.05473238,0.03857949,0.09056134,0.08946972,-0.029337453,-0.08075243,0.05312929,0.042844124,-0.053539317,-0.0073264237,0.051077936,-0.018648123,-0.019697819,-0.10855347,4.1715235e-33,0.054469377,0.05522102,-0.009965238,0.0014529065,0.0058644037,0.010428706,-0.08154087,-0.012103289,-0.022733483,-0.10329978,-0.019556703,-0.034045443,-0.041171927,0.0026471436,-0.010138992,-0.026005482,-0.025857162,-0.051737156,0.12465491,-0.019744514,0.02501143,0.01957086,-0.029161917,0.008448266,0.05718148,0.06972893,0.02590532,0.031085033,-0.06566903,-0.006846227,0.042210165,-0.055547446,-0.1117747,-0.007317851,0.07518617,0.03308367,-0.019974593,0.0054049795,-0.087404355,0.05587262,-0.0085921055,0.07036921,-0.023484996,-0.05158097,0.067250416,-0.111215614,-0.0742791,0.13054204,0.023396583,0.14674711,-0.0019842514,-0.024080727,0.058269903,0.02064159,-0.097071916,0.015535036,-0.031643312,-0.020437155,0.01240167,0.058740746,0.0980458,0.03443833,0.0016668682,0.08601044,-0.03142882,-0.053652756,-0.052676573,0.032177724,0.033130527,0.06175938,-0.09400709,0.04288907,0.028459424,0.017411092,0.055319887,-0.11103765,-0.08923994,-0.018959349,0.0789055,0.025495958,0.038213257,-0.06429365,0.07890822,-0.0055895317,-0.11919051,0.027648788,0.0023524896,0.00936767,-0.008841275,-0.038563725,-0.0035337633,-0.043120213,-0.05549138,0.026133042,-0.034260973,-4.7294487e-33,0.06132352,-0.11802143,0.12689883,-0.054992873,-0.099167556,0.014621141,-0.0144667085,-0.014260307,-0.013731709,0.025730645,0.1260614,0.039631847,-0.029558199,-0.058683235,0.06046378,0.06503492,-0.0034205,0.02233069,0.018664265,-0.02474796,-0.0154781435,0.058244746,-0.0692225,0.02713607,0.08990257,-0.014225566,-0.048796967,0.008237203,0.07779816,0.09078565,0.009545342,0.023976842,-0.040964153,-0.061105333,0.013654745,0.016379116,-0.06669234,0.02645724,0.022631709,0.08189651,0.030678444,-0.021854106,0.04521259,0.04151235,-0.012452173,0.007332271,-0.043499645,-0.027270464,0.053075925,-0.061885037,0.013136999,-0.026587775,-0.08000063,0.0071436423,0.051104266,-0.004858244,0.009576511,0.033970322,-0.02870606,-0.02075216,-0.055588655,-0.036570977,-0.003046573,-0.05335337,0.031694997,0.0506201,-0.017918395,0.044113852,0.056660574,0.037795108,0.03578622,-0.019230602,0.026914263,-0.0031989457,-0.111930355,-0.009192794,-0.016045088,0.06321396,-0.015244313,0.041042976,0.073519796,0.0005691275,0.011778819,-0.033846267,-0.007985701,-0.059929546,0.00036697465,0.07139184,-0.07611083,-0.009784874,-0.05282728,-0.0013102395,0.017360428,-0.02098299,-0.01192753,-4.3003283e-08,-0.03564695,-0.032638717,-0.0032971536,-0.03784301,-0.034515176,0.009785512,-0.008247331,-0.072357,-0.002138213,0.021705704,-0.03660218,0.056394547,0.023974732,0.0113026025,0.0011288624,-0.02045498,-0.03382049,0.032177657,-0.009962079,-0.00401267,-0.114214,-0.019894445,-0.14959595,-0.020553984,-0.01851133,-0.0046879235,0.044344302,-0.062890396,0.054193467,0.023180438,-0.03982707,-0.012910208,-0.040056378,-0.041342575,-0.062610015,-0.0013831288,-0.038002543,-0.05607633,-0.10944231,0.0035022115,0.0651109,-0.08592742,-0.049751826,0.0015855014,0.09708468,0.010772162,0.025157215,0.008790974,0.010603982,-0.043678008,0.10980539,-0.032116953,0.029740369,-0.014325292,-0.070994295,0.11990672,0.055016045,-0.03949704,-0.011153289,-0.05942742,-0.010186315,-0.006949016,0.096050955,-0.0038295428 +4.99.1.7,"The enzyme from Bacillus sp. OxB-1 contains protoheme IX, the iron of which must be in the form iron(II) for activity. (Z)-Phenylacetaldoxime binds to ferric heme (the iron(III) form) via the oxygen atom whereas it binds to the active ferrous form via the nitrogen atom. In this way, the oxidation state of the heme controls the coordination stucture of the substrate---heme complex, which regulates enzyme activity [2]. The enzyme is active towards several (Z)-arylacetaldoximes and (E/Z)-alkylaldoximes as well as towards arylalkylaldoximes such as 3-phenylpropionaldoxime and 4-phenylbutyraldoxime. However, it is inactive with phenylacetaldoximes that have a substituent group at an alpha-site of an oxime group, for example, with (E/Z)-2-phenylpropionaldoxime and (E/Z)-mandelaldoxime. The activity of the enzyme is inhibited completely by the heavy-metal cations Cu+, Cu2+, Ag+ and Hg+ whereas Fe2+ and Sn2+ have an activatory 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+5.1.1.1,A pyridoxal-phosphate 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+5.1.1.2,A pyridoxal-phosphate 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+5.1.1.3,A pyridoxal-phosphate 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+5.1.1.5,The enzyme is involved in a lysine catabolic pathway.,384,0.99999994,0.0031009698,-0.09395331,-0.09428322,0.023287341,0.06737198,0.03262647,-0.04733464,0.025139628,0.023562953,0.0035095108,0.012469565,0.02049963,-0.010542329,0.041379478,-0.005752934,0.08278212,-0.13677678,-0.051423345,-0.007509924,-0.0371804,0.044558007,0.066132896,-0.025792826,0.029831994,0.014063032,-0.06855804,0.07904848,-0.056093514,-0.06292994,0.0044849245,-0.012318367,-0.053080637,0.0041189976,-0.005315338,-0.0015983062,0.05219534,-0.049679954,-0.047939148,0.054187875,0.02363783,0.007889704,-0.069137305,-0.06041908,-0.036114976,-0.05485576,0.0019261815,0.021290367,-0.025194991,0.0013676267,0.073028795,-0.043354716,-0.07253613,-0.042707384,-0.003032315,-0.072035566,-0.0036563927,-0.091733925,0.04754887,-0.00085926976,0.04447405,0.00089647126,0.049625676,0.031680826,0.050783135,0.11439552,-0.07426028,0.029092345,-0.03614315,0.03510081,-0.10376178,-0.031506874,-0.11454809,-0.007529178,0.006597541,0.048829135,-0.036689185,0.041151393,0.048282336,0.03454152,-0.037343055,-0.009276909,-0.033222508,0.024161201,0.1284376,0.039053567,0.020927316,0.019692818,0.03574588,0.029504916,-0.0077475235,0.05519079,-0.0876719,-0.063338116,0.016067816,-0.056743074,-0.041726515,0.009412239,-0.022739248,-0.027625857,-0.012316531,-0.008503906,0.053421535,0.006387524,0.022086,-0.05838195,0.0003969392,0.048132278,0.035310138,-0.017102843,-0.05275179,0.038835127,0.013002573,0.076536335,0.062951624,0.04118871,0.09337677,0.021524066,-0.02523252,-0.039868638,0.008547367,0.021066979,0.02526312,0.059103716,0.09872989,-0.085106656,0.089673035,-0.093616866,-2.812354e-33,0.04179975,0.008584314,0.012306032,-0.039871234,0.012139966,-0.010060476,-0.05710925,0.035413135,-0.032518234,0.017708402,-0.07461469,-0.040438723,0.104394026,0.0026363202,-0.048786864,-0.033780467,-0.037432984,-0.026574405,0.06331664,0.056993473,-0.009259837,-0.002934134,0.021299984,0.048087746,-0.023233494,0.05478122,0.025034972,0.07194828,-0.016659513,0.011725262,-0.04766596,-0.1388523,-0.01803155,-0.012186859,-0.008654978,0.0022028403,-0.0054559154,-0.037534054,0.029085163,0.035531625,0.0058010174,0.0014343833,-0.014738169,-0.031087255,0.04722687,0.009594514,-0.04280936,0.08640324,-0.045907196,0.045218915,0.11124899,-0.101473704,0.10395193,-0.075750485,-0.067931205,0.010338654,-0.06762925,-0.01813356,0.0244946,0.07736852,0.048969336,0.07584899,0.019802114,0.082486324,0.0061301156,0.013260834,-0.025262695,-0.0776972,0.005070238,0.059097413,-0.09514857,0.03288175,0.093985155,-0.023916068,0.072139785,-0.041606445,-0.08199373,0.021586703,0.009772265,0.022327553,0.031689923,-0.081531346,-0.016474832,0.040097557,-0.025391055,-0.02940822,0.016902769,-0.0874161,-0.071308896,-0.0028727967,0.012337695,-0.02684726,-0.00913502,0.014826344,0.06343697,6.2037743e-34,0.09125281,-0.11316996,0.033970848,-0.07063612,-0.019318555,0.024185097,0.07758652,-0.05265656,0.07779579,0.025130512,0.05388549,-0.012869587,0.001215606,-0.05001094,0.03229099,0.041669082,-0.048271835,-0.0016281573,0.01253779,0.01389928,-0.025085552,0.05699453,0.01448447,-0.010299025,0.054428663,0.0092332,-0.038045224,0.09682599,0.021731637,-0.03503389,-0.006572486,-0.04809022,-0.028646583,-0.09556298,-0.030885711,0.09445778,-0.045684278,-0.045206822,0.027000898,-0.06553708,0.006656118,0.010566067,-0.009739672,0.049833942,-0.02688633,0.04891058,-0.051374592,-0.0073133027,-0.040893074,-0.07311763,0.0053511527,-0.02251924,0.040812526,0.047962192,0.0049579157,0.087790996,-0.040970623,0.033420883,-0.077507764,0.020189265,-0.017003568,-0.004741635,-0.0030130956,0.061596666,0.034069996,-0.05083031,-0.03980677,0.018919636,0.020898443,-0.016170645,0.12693898,0.0014108492,0.031567305,0.070630796,-0.05214547,-0.0067450968,-0.07702488,-0.08774859,0.0019732222,-0.06458708,-0.046262976,0.0063538337,0.012447593,-0.054624505,-0.021052249,-0.06811472,-0.021753537,0.1394173,0.09028046,0.023979995,0.011476321,-0.05282001,-0.024782807,-0.028543863,0.09259842,-2.2472781e-08,0.03632873,-0.09546266,-0.0018072597,-0.03333059,-0.0070695723,0.039258827,0.031398047,0.034764104,-0.03760899,0.009583518,-0.0038547213,0.038143594,-0.005467269,0.0018355778,0.0021161954,0.062247958,-0.011140639,0.052398365,-0.021715298,0.010923123,-0.05063794,-0.012973114,-0.09466816,0.013644447,0.057767935,-0.0742294,-0.03475979,0.03451746,-0.03815917,-0.07129662,0.056181327,-0.020506103,0.05039134,-0.07783156,-0.10695208,0.03196572,-0.016614296,-0.024633186,0.028807301,0.046113428,-0.021081232,0.010948936,-0.048092466,-0.0076104444,-0.0031611638,0.03708294,0.0011484945,-0.025147788,0.050831836,0.0063595236,0.004791817,-0.006961757,-0.0023025759,-0.023861794,-0.036468703,-0.0008050575,-0.062210366,-0.06098712,0.02287498,-0.09543124,0.0020230936,0.104990155,0.22723632,-0.090729326 +5.1.1.6,Inverts both chiral centres.,384,1.0,-0.019421011,-0.12103883,-0.049631827,0.04788823,-0.037920743,-0.054082476,-0.047339465,0.023765406,0.058250416,0.031977557,0.14695711,0.020309465,-0.0047413446,-0.00153835,0.05767846,0.11023685,-0.07217451,0.015913093,0.028807357,0.07669352,-0.032498438,-0.09085904,-0.008838965,-0.004497168,-0.019866986,0.01520025,-0.055541094,0.05467519,-0.015222177,-0.08226642,-0.02397986,0.068192676,-0.04111245,0.027783383,-0.08085382,0.026480349,-0.022327194,0.06565612,0.09202899,-0.021914106,0.0633501,-0.042557634,0.032591667,-0.04443254,-0.022098137,0.043159608,-0.055886373,0.037738476,0.06615563,-0.050740972,0.008110845,-0.015947979,-0.05116783,0.05496743,-0.07268611,0.15069374,-0.07747204,-0.0019921127,0.074365236,-0.0078008813,0.05888997,-0.0038661773,-0.048142515,0.033466183,0.010487057,-0.031671282,-0.0018076015,-0.023088764,-0.035355616,-0.002048792,0.014996939,-0.045418695,-0.09450889,-0.08133845,0.056403298,0.024327368,-0.01691703,-0.06014517,0.012191504,0.05428675,-0.002532944,0.04730595,-0.031184945,0.058531016,0.029866792,0.0056727543,-0.020683372,-0.030306721,-0.08548334,0.0029295622,0.027339315,-0.05647211,-0.04030008,-0.05463191,-0.00041956737,-0.038394116,0.01651231,0.017070536,0.06653174,0.004568048,0.08089071,-0.021632988,-0.03018191,0.0023287605,-0.03314417,0.011903893,0.047240183,0.003296335,-0.01770926,-0.059354827,0.0075042127,-0.005686256,0.10979655,-0.07147027,-0.050150916,0.105945915,0.04236872,0.08557694,0.051618535,0.05851089,-0.02481878,0.012760531,-0.031508088,0.07713311,-0.027307194,-0.026470607,-0.07958811,8.551634e-35,0.00052439224,0.010169758,0.09048838,0.007249253,-0.060530547,0.053765025,-0.062214915,-0.032959938,0.05978886,-0.021136725,-0.057913974,0.0418347,0.009308495,-8.176493e-05,-0.108308606,-0.026278766,0.019815305,0.037907064,-0.0800033,-0.117720895,-0.046472486,0.12690322,-0.06066918,-0.053418513,0.048159227,-0.028089097,0.013388196,-0.04284711,-0.008540651,-0.008139353,0.06491149,0.07160399,-0.052302636,0.07805849,-0.04093672,0.14220424,0.00097456854,-0.052787058,0.024517622,0.108941086,0.018203484,0.07409811,-0.059313785,0.012979353,0.036387596,0.008627353,0.039331857,-0.0380949,0.058651734,-0.07587271,0.030281994,0.027811514,-0.07687089,-0.017892258,0.06978828,0.037216067,0.050209895,-0.0023670108,0.005502552,0.02444494,-0.0358316,-0.057757158,-0.05994688,-0.081705764,-0.040628556,0.009258511,-0.04261916,-0.12098418,-0.032770235,0.023930639,-0.05941311,0.028599843,0.029477637,0.025569582,-0.019604411,0.032167345,-0.04062407,0.011206228,0.0051700477,-0.010183103,-0.1016122,0.03257636,-0.071190886,-0.025623675,0.003857516,0.035539944,0.008128057,-0.07964107,-0.022133602,0.029183118,-0.0026174637,0.013354805,-0.01765345,0.013599083,-0.022533305,-8.245035e-34,-0.106281735,-0.0830674,-0.031929918,0.022481779,-0.01731054,0.071875535,0.0696819,0.0047371774,-0.026607981,0.027136294,0.08380791,0.047283005,0.023948183,-0.05983028,0.036825117,0.008405403,0.080099024,0.1205098,-0.029106252,0.008936443,-0.011527099,0.0893237,0.05457167,0.059274904,-0.059863996,0.06446666,-0.01926309,-0.0062586484,0.08507469,0.09504319,-0.05091058,-0.0028789502,-0.04233435,0.024268478,-0.062328476,0.031237593,-0.11221339,0.004527315,-0.09866375,-0.0078515,-0.06004562,0.020052988,0.060859267,0.02630148,-0.0132073825,-0.024666658,0.08043504,-0.027215607,-0.06585763,0.0153389815,-0.03226836,-0.034114707,-0.034843724,0.017504983,-0.014296788,0.018073311,0.009099779,-0.0019658655,0.058951113,-0.041591275,-0.012000308,0.010173509,0.07424837,-0.14203642,-0.038036957,0.10569985,0.08169397,0.03847658,0.05911768,0.007929321,0.04419497,0.07149298,-0.019095466,-0.069923736,0.06410749,0.023912067,-0.033958953,-0.07890723,-0.024860865,-0.06106517,-0.11373954,0.00080547185,-0.014700901,0.016778171,-0.010315673,-0.04224743,0.012852153,0.032491423,0.0069885324,0.074446596,-0.017834729,0.039137814,0.044465993,-0.0027209218,0.09437075,-1.4381913e-08,-0.0032136503,-0.04961847,0.08381969,0.031534366,-0.08015439,-0.05275575,0.076795086,0.0013788795,-0.022196345,-0.009816394,-0.04016153,0.092052326,0.07132762,-0.026404196,0.08328788,0.063474365,-0.022570172,0.01035833,-0.020700296,0.00068451266,-0.023260199,0.041229185,0.013862597,-0.015809933,-0.023510896,0.015372542,6.7558714e-05,0.046857264,-0.062330753,0.019903993,0.041706927,-0.0026836388,0.039682306,-0.023979703,-0.070721895,-0.012232127,0.0088595245,0.01612653,-0.010010801,-0.0016243205,-0.005938065,-0.046155922,-0.024097351,0.04840981,-0.048225794,0.020064283,0.028318392,0.07362166,0.005352667,0.019947015,0.00020994327,-0.0004609731,0.033945326,-0.033621147,-0.09274056,0.008914836,-0.007714071,0.057363346,0.00869768,0.022668742,-0.044229247,-0.022998773,0.017414773,-0.045413136 +5.1.1.8,Also interconverts trans-4-hydroxy-D-proline and cis-4-hydroxy-L-proline.,384,0.99999994,-0.06801218,-0.07277258,-0.033701483,-0.048626754,-0.009033437,-0.024837887,-0.01684489,0.06036272,0.0018594377,-0.046587806,0.055570215,0.010512271,0.014980955,-0.015661146,0.0030292054,0.08408162,-0.032973174,0.04215067,-0.018621083,0.0055202497,-0.010348458,-0.07812394,-0.0085835885,-0.016720846,-0.025137646,0.0136431325,0.06315604,0.057941195,0.01571974,-0.038040802,-0.03640965,-0.017227411,-0.008373563,-0.046379633,-0.017630018,-0.06319265,0.05630659,-0.0013022528,0.042759538,0.02061413,0.07638563,-0.05895559,0.08514893,-0.037325855,0.0029269895,-0.020327637,-0.105919234,-0.018594218,0.05311321,-0.08612359,0.005569493,-0.0004167506,-0.08630587,0.086879775,-0.051861797,0.074491896,-0.05556412,0.042399056,0.019720513,0.056348324,0.03563669,0.03188959,-0.010937524,0.040016126,0.0055967458,-0.013070457,-0.028241072,0.079109214,0.00938912,-0.011198336,-0.10037213,-0.06257381,-0.020957435,0.0017269701,0.03158951,0.008820735,0.058474675,-0.06720384,0.040452927,-0.044337474,-0.018643405,0.12238416,-0.0055009723,0.0067277756,0.0552984,0.010905319,0.035798788,-0.018026683,-0.029794563,-0.044419326,-0.008448417,-0.019944282,-0.070685215,0.03454283,-0.07174759,0.043539423,-0.0142318765,-0.025553394,0.03166146,-0.011660191,0.0060148407,0.0020047638,-0.07984474,-0.11245733,-0.13378233,0.024394823,0.003905987,0.14761834,-0.057825413,-0.007314654,-0.036523182,-0.029464994,0.0070220735,0.011858258,-0.034549348,0.035757117,-0.00598945,0.018137956,0.104413465,-0.065589584,-0.054634776,0.003018797,0.028620962,0.040621813,-0.058023836,0.012103214,0.046549458,-5.17017e-34,0.009722392,0.047885403,0.03284712,0.052368674,-0.036474604,0.07092559,-0.14726137,-0.04598971,-0.01401147,-0.022830999,-0.07830754,-0.027248757,-0.013391955,0.042771105,-0.006005257,-0.08309423,0.018449511,0.015590444,0.023920547,0.021291433,0.0015901306,0.09226187,0.025547296,0.022996118,0.074891515,0.00016076704,0.0458208,0.011062776,0.031754766,-0.00079394993,-0.023062017,0.008694102,0.0047793766,0.020579904,-0.059803832,0.13283598,-0.07132019,-0.0936237,0.046984624,0.13835382,0.0065336535,-0.003806175,-0.000719133,-0.02073352,0.054243382,-0.029955711,-0.032578673,0.1060693,0.014546937,0.033840865,-0.042308994,0.03500752,-0.017462667,-0.050169438,0.00022358126,0.021475954,-0.02107281,-0.012642013,0.05392856,0.072488315,-0.053298935,0.044328976,-0.079154134,-0.009623794,0.059697878,0.044593297,-0.022949426,-0.06098756,-0.07976646,-0.019960014,-0.105669096,-0.020300765,0.0856513,0.028673513,0.034801617,-0.023519365,-0.13848507,-0.030207513,0.047451638,0.00936547,-0.055950165,0.053031027,-0.013498792,0.03927271,0.011519894,-0.029047683,-0.0034764048,0.0024453907,0.046550035,-0.0013150643,-0.0075009596,-0.03155465,-0.026169112,0.0048486823,0.0042760186,-1.0710849e-33,-0.0047269473,-0.04590325,-0.001361956,-0.018644499,-0.0062709698,0.016196653,0.11671837,-0.10361762,0.06688836,0.07169576,0.1609249,-0.011474502,-0.026455825,-0.039210856,-0.02948055,0.015427687,-0.06887939,0.0047391704,0.030963054,-0.023573771,0.09198939,0.059330683,0.071291395,0.07734523,-0.004988082,-0.029700488,0.06777448,0.030750344,0.03360225,0.14000301,0.009633276,0.00064137817,0.008088104,0.038997255,-0.07922301,0.073693596,-0.02354581,0.027566867,-0.040305912,-0.038777146,-0.051409982,0.010810244,0.06576441,-0.026517097,-0.06636966,0.027096087,-0.060766395,-0.03791028,-0.011487894,0.030332461,-0.022192365,-0.006834874,-0.03463999,-0.029320369,-0.016910328,-0.048974793,-0.05954197,0.043541748,-0.06643443,-0.00731775,0.011066034,-0.06991227,0.04741272,-0.105606586,0.06451024,0.008124499,0.04567127,-0.083598085,0.09046647,-0.03014793,0.12665246,0.025425784,-0.012719356,-0.050465964,-0.013599977,-0.109214574,0.037094437,-0.054139398,-0.026204128,0.035298128,-0.0015630596,-0.060259786,0.044641163,-0.005206328,-0.029355196,0.03607953,-0.05703297,0.096217014,0.068441056,0.08379566,-0.0001231454,0.06985541,-0.007889381,-0.0038370434,0.03585746,-2.6047037e-08,0.036673017,-0.019218827,0.06544567,-0.034065213,-0.05416664,-0.034104876,0.02053092,-0.022903148,0.03322769,-0.107132055,0.0035128836,0.053852063,0.0035972737,-0.04891476,0.0975946,0.020018196,-0.020119252,0.038719594,-0.03873418,-0.0019265199,-0.08774081,-0.053438187,-0.041841213,0.05112468,0.020303858,-0.019656744,0.07306458,0.012316878,0.0073872055,0.005913477,0.039179154,-0.032635096,0.023839824,-0.06887359,0.017480323,0.06563017,0.023975989,0.012125027,-0.019593064,0.041966815,0.018246181,-0.06612437,-0.002943796,0.02894787,0.04039695,-0.017859174,-0.036052495,0.06460658,-0.027633922,0.050028086,-0.02910875,0.028699497,-0.01791499,-0.12129923,-0.101156525,0.037157755,-0.06952365,0.038097635,-0.011966466,-0.014216494,0.03912447,-0.0038461478,0.13951722,-0.022861537 +5.1.1.9,A pyridoxal-phosphate 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+5.1.1.10,A pyridoxal-phosphate protein.,384,1.0,-0.027926251,-0.08266997,-0.068644024,-0.07361168,0.027612092,0.000692783,0.04313638,-0.002219875,0.07759756,0.061581407,0.050052587,0.024383713,-0.07972975,0.07563026,-0.01806299,0.011146783,-0.058814343,0.026981095,0.028646503,-0.060484953,0.080625795,0.046058826,0.013964568,-0.0034948576,-0.02263515,0.093175426,0.03897883,0.08481282,-0.022757838,-0.06512059,-0.03364559,-0.0024382183,-0.04265654,-0.08132628,0.049699724,0.09206188,-0.104265444,0.024624586,0.016413575,-0.038264275,0.091385536,-0.069951184,-0.01917849,0.015225988,-0.07975409,-0.009005384,0.060174435,0.061216116,0.107678145,-0.0044862656,-0.08720913,-0.014019614,-0.013987483,-0.04995591,0.010103787,0.044394664,0.02575669,0.03877334,-0.030249706,-0.031439885,-0.01887598,-0.014899664,0.03318374,0.030056322,0.045147125,-0.038637787,0.01169653,-0.046883456,-0.028674731,-0.004087979,-0.039980926,-0.0017529979,0.12130533,0.0010539007,-0.03463635,0.097280316,-0.028074516,-0.023704544,-0.040408697,0.05543277,0.03498064,0.00886841,0.038521886,0.08173243,0.056242187,0.029562093,0.015032838,-0.00867073,-0.06712045,-0.034980316,0.0024070796,0.025017872,0.03384473,0.034312956,-0.017365376,0.020294162,0.0095835,-0.017277343,-0.04915634,-0.05037138,-0.013552024,0.00656036,0.029906167,-0.049250327,-0.040218867,-0.005961337,-0.07031904,0.041368306,-0.008511045,-0.004005959,-0.05803714,0.081046164,-0.012979449,0.0061077774,0.023425987,0.02263995,0.016739294,-0.004660243,-0.056521032,0.057704546,0.0031750335,-0.032194555,-0.030190023,0.088592544,-0.054773748,-0.05421068,-0.07686094,-2.4678308e-33,0.06313786,0.07412098,0.050783474,0.040298082,-0.011358973,-0.01422413,-0.062849306,-0.05458463,-0.06972206,-0.006010217,-0.0058378144,-0.041249327,0.07401364,0.007710771,-0.077794835,-0.03148978,-0.09894452,0.03780527,0.09449974,-0.05431621,0.03634753,0.122786604,0.015729478,0.0657317,-0.023447253,0.1053523,-0.047188897,-0.017551295,-0.020911038,-0.010473478,0.017130267,-0.08890348,-0.10486217,-0.03721676,0.029635092,-0.10321067,-0.05313732,-0.08824496,-0.028489998,0.010690022,-0.031340744,-0.06654561,-0.015844459,0.03225438,0.0052287155,-0.125025,-0.022130566,0.049036924,-0.044415865,0.030424977,0.039240222,-0.065284304,0.07721516,-0.002264942,-0.14055416,-0.054724995,-0.056979876,-0.04121838,-0.0039615883,0.03630682,0.05593311,-0.0074688247,-0.07769675,0.005927352,-0.0073402086,-0.052448913,0.016444825,-0.06923202,0.06292545,0.0814676,0.07062608,-0.02118333,0.08123211,0.022367148,-0.017924992,-0.006955072,-0.03999482,0.044533312,-0.028805202,0.099463984,-0.022619031,-0.06887749,-0.055661418,-0.031518426,-0.050702445,0.0006394598,0.02549736,-0.057537362,0.047344796,0.00027533007,0.030769037,-0.11320942,-0.06804346,0.018650118,-0.03014129,3.6575112e-34,0.07618565,-0.056287877,0.10101467,0.0071092336,-0.05566321,-0.003068117,0.07742765,0.020468358,0.023406565,0.0041982173,0.03505829,-0.010533478,0.015140456,-0.066251345,-0.0047525074,0.05485972,-0.009271999,-0.0056528086,0.058509674,0.040260103,-0.0036931236,0.011792275,0.016480204,0.096511245,0.05376125,0.075716525,0.014522438,-0.0019530549,-0.075527206,0.02991125,0.03048249,0.07004556,-0.041487813,-0.06104291,-0.052007295,-0.008271354,-0.09736283,-0.01278193,-0.006976577,-0.020985894,0.01615118,0.054984502,0.062825225,-0.0045873076,0.010520163,0.042866435,0.027957125,0.024932984,-0.002186217,-0.041766208,-0.009070507,0.099441014,-0.007978718,-0.04209436,0.04130014,0.017322244,-0.04780977,0.014699126,0.035344042,0.037282575,0.0067929,-0.06915583,0.014899644,0.107453205,0.030028796,0.10507641,0.04695868,-0.016195958,0.03677606,0.0776874,0.059881844,0.04023669,0.05812131,0.10574303,-0.044964254,0.016713472,-0.053298533,0.0765124,0.008037235,0.01486838,-0.019268397,-0.016083373,-0.046088148,-0.09191056,0.043844376,-0.024019063,0.045906503,0.05475791,-0.007998666,-0.0261561,0.03149767,-0.009735426,-0.027109586,0.037469704,0.075646736,-1.9977726e-08,0.09066989,-0.047100347,0.021396242,-0.09606709,-0.006367038,-0.007103559,0.06365688,0.0046284148,0.061157428,-0.0008820028,0.02457906,-0.020273902,0.04703945,0.0047757947,0.03248542,0.07582299,-0.019408086,-0.021913707,0.01939175,-0.07981514,-0.047403537,0.0019364234,-0.10317197,0.007531202,0.07142011,0.010388321,0.004406287,0.00833137,0.0018802729,0.001934282,0.061034903,-0.033622324,-0.007979504,-0.07862822,-0.00163751,0.089614086,-0.014804381,-0.025552798,-0.07120054,-0.016167762,-0.083521485,-0.008883199,0.020114034,-0.038908724,-0.007578423,0.06274983,-0.06097855,0.019942012,-0.03509062,-0.040864494,0.038964584,-0.0051311594,-0.07638947,-0.08036237,-0.15321007,0.046325188,0.03961433,-0.041317683,-0.012306582,-0.08768255,-0.037958544,-0.054651964,0.07941701,-0.07056296 +5.1.1.13,"Also acts, at half the rate, on L-alanine.",384,0.99999994,0.07410349,-0.14724721,0.004682429,-0.053503554,0.023635032,0.13669607,0.046912152,0.021079782,0.034205828,0.050565116,0.02586382,-0.014930916,-0.040524,0.043575585,0.050731316,0.051512685,-0.005223186,-0.030937254,-0.059323695,0.0016584849,0.0044889413,-0.01211756,0.03379141,0.0040828865,0.018397799,-0.036645718,-0.05199321,0.0077505643,0.02906879,-0.10818116,0.05508522,0.035033677,0.042066365,-0.021068728,-0.08976108,0.07868132,-0.036422215,0.004234085,-1.41917935e-05,-0.0048832702,0.07524623,-0.007529484,-0.011388044,-0.022189967,-0.10223375,-0.050232295,-0.049800567,-0.015548729,-0.01238476,0.07099957,-0.0022368724,-0.050961,0.022049647,0.0010109765,-0.07283346,0.016874518,-0.12466896,0.01868024,0.022098806,-0.030915761,-0.03756349,0.08594817,-0.039125264,-0.0054804254,-0.029958474,0.003015194,0.013297164,-0.049810283,-0.027987512,0.003902016,0.009434695,-0.089674264,-0.010309228,-0.040219937,0.005307867,-0.07176026,0.0031600515,-0.025809098,-0.029844532,-0.07664107,-0.04361488,-0.08807958,-0.04506924,-0.022840448,-0.016151275,-0.04818412,0.033632014,-0.03466735,0.0051540122,0.01674021,0.015031808,-0.04687133,0.021459548,0.01510267,0.09301701,0.029294783,0.0027048816,0.048228767,-0.05166408,0.033421073,-0.045542426,0.051927615,-0.06397602,0.014356582,-0.080534525,-0.07393029,-0.024107514,-0.00264185,-0.068139546,-0.04019342,0.022054689,-0.034075897,0.04937306,0.038575,0.0904406,0.018882817,0.016952705,-0.019013964,-0.055986375,-0.035330057,0.087136745,0.017407514,0.030708706,0.08443696,0.020220421,0.11123347,-0.04615933,-4.5643803e-33,0.03695643,-0.042788293,0.051055387,-0.07513355,0.02722283,-0.051784273,-0.073363036,0.114786394,0.07431357,-0.037802726,-0.042870864,-0.069240704,0.028411027,-0.0477778,-0.035687942,0.032014605,0.034491617,0.007212758,-0.00048664163,-0.004991636,-0.04970981,0.11394,-0.049326867,0.032956414,-0.024158483,-0.0417915,0.09891092,-0.015295921,0.040537678,0.017789576,-0.017550254,0.007488158,-0.051041976,0.0456325,0.008090884,0.10639133,-0.083378136,0.009871313,-0.009015992,-0.001979785,0.017044779,0.04873052,-0.031082606,-0.007959006,-0.081996836,-0.042813286,0.0045931656,0.031476166,0.010356891,0.055768367,0.111760736,0.0033153244,0.030955052,0.009466207,0.030909555,0.07361563,-0.00042879104,0.095816284,0.009290241,0.09721913,0.09077641,0.026674105,0.06442277,0.012423344,-0.08787538,0.013955791,-0.0375103,-0.09039207,0.032698654,0.021951314,-0.06314583,-0.016755253,0.10229513,-0.02299149,0.014741037,-0.047291636,-0.008523081,-0.057640165,0.0022173277,0.01651333,-0.054288775,-0.028482175,0.040856402,-0.006061801,-0.01351836,-0.11075518,0.09338278,-0.12569322,-0.058237612,0.0056125796,0.00052921096,-0.0014260764,0.014615883,-0.008421184,-0.03008879,2.393125e-33,-0.0042919614,-0.070768885,0.021778056,0.12387996,0.008045657,0.03987532,0.012467021,0.034963332,0.07574658,0.024989966,0.030658823,0.018892726,-0.03479833,-0.070364684,0.07960758,-0.0695922,0.066733666,0.030517599,0.04741847,0.02291732,-0.010563329,0.04717674,0.09565547,0.019153908,-0.006172327,0.0052607767,-0.018659856,0.030525208,-0.008149225,-0.037529375,0.0048723137,0.027589284,-0.0652633,-0.15741535,-0.10905291,0.081733495,-0.010483279,0.03730948,-0.0066381115,-0.008294341,0.009581342,-0.060160022,0.015810963,0.118121505,-0.019206682,-0.014244351,0.034372784,-0.015669627,-0.10325477,-0.01862442,-0.045215983,-0.017107362,-0.046381023,0.04880268,0.03575267,0.07393622,0.004940149,-0.07265603,-0.061962906,-0.006497903,0.018324653,0.039664492,-0.080803886,-0.015796732,0.069608875,0.005999146,-0.0043885466,-0.0072269146,0.043989275,0.022234151,0.099246666,-0.033514183,-0.03031482,0.06667854,-0.06624164,-0.04177043,0.0009106742,-0.10835131,0.0054849098,-0.10597269,-0.0515882,-0.02327535,-0.034908313,-0.03781312,-0.096891314,-0.0017858659,-0.009255088,0.05292367,0.0005259694,0.08359763,0.030480022,-0.054759454,0.018711295,0.0014349283,0.01804442,-2.1253694e-08,0.00079613866,-0.026981529,0.031483445,0.036978994,0.03125592,0.058318812,0.00576972,0.09733287,-0.019038668,0.1152606,0.042165857,-0.016453607,0.026875427,-0.053649332,0.099628694,-0.01522519,0.017124107,0.07212378,-0.10484394,0.058088563,-0.089183815,0.024980815,0.044840604,-0.08064199,-0.05132661,-0.003364056,-0.014478028,0.039270133,0.00438744,0.0013371661,0.027207825,-0.0015208593,0.08240037,-0.06658446,-0.04641781,0.006056063,0.04233975,0.0027259248,-0.018345373,0.04475825,-0.0073214835,0.0010505577,-0.015163031,0.040061824,-0.009623347,-0.010867286,-0.036102332,-0.02592856,0.049098138,-0.055800308,0.109205,0.055999197,-0.0139033785,0.04537142,-0.0068257954,0.07259008,-0.08379881,-0.0319079,0.038942177,-0.01566227,0.047374558,0.0034748274,0.03680172,-0.020295246 +5.1.1.14,"Requires pyridoxal 5'-phosphate. The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A. It catalyses the epimerization of the amino group at position 9' from (S)- configuration to (R)-. The enzyme can act on both isonocardicin A and isonocardicin C, but the in vivo substrate appears to be the latter [3].",384,1.0,-0.010385005,-0.023022871,-0.112358004,-0.061631847,-0.0022506653,-0.0024344146,-0.048708957,-0.0031697669,0.04343325,-0.018027518,0.090990536,-0.01819024,-0.07144778,0.13030742,-0.03274929,-0.031608112,-0.06142465,-0.025521632,0.021211348,0.014554939,0.0626213,0.05308504,0.032913074,0.005084264,-0.017201465,0.03893318,0.035364315,-0.027918864,0.0059965705,-0.10094134,0.06633104,0.012258961,0.13031423,-0.04767776,0.06332727,0.06318561,-0.06260346,-0.00557318,0.05586684,0.03695261,0.047415156,-0.032656036,-0.002287568,0.03481139,-0.025863538,-0.014127419,0.06015355,0.0614714,0.035689943,0.021012027,-0.04501628,-0.052258015,-0.047963005,-0.04182367,-0.0029465028,0.01418125,-0.028844137,-0.06319399,-0.030924786,-0.09503186,0.059207696,0.02243949,-0.007891642,0.053946786,-0.038502347,-0.02531118,0.026207032,-0.097140744,0.010581672,-0.0065045515,-0.015978612,-0.038859475,0.07997971,-0.019935738,-0.022805784,0.017183289,-0.06390542,-0.04046885,-0.016474223,0.011334117,0.013875402,-0.0010453357,-0.02626077,0.083133526,0.027542697,0.009976432,0.03674777,0.05095736,0.043189447,-0.046694797,0.058572147,0.016437514,0.022808002,-0.007917281,-0.05639695,-0.0069353087,-0.04786777,0.04910084,-0.02697261,-0.044331133,-0.00119554,-0.00043295498,-0.09317458,-0.0015469203,-0.035904422,0.014860394,0.0023264093,0.01034396,0.06423496,0.03080842,-0.02506056,0.010957933,-0.02586978,-0.0056067957,-0.008842068,0.032309383,0.048859708,-0.05873998,-0.057223435,0.1259759,-0.024886198,-0.06792146,0.00680232,0.046080176,-0.080013715,0.093247525,-0.055599976,2.5535071e-33,0.03223363,0.06353482,0.03832331,-0.056493796,0.08721094,-0.013559198,-0.055840332,-0.048314933,-0.04365949,-0.045945138,-0.08763008,-0.040252596,0.013282903,0.06343647,-0.053261522,-0.020681027,-0.03105726,0.04757143,0.061316065,0.0362481,0.026982794,0.043142736,-0.060032688,0.026787255,-0.018132383,0.13430335,-0.0034524582,0.040275026,0.081863694,-0.029590478,-0.0006670808,-0.105941616,-0.047161903,-0.0090753045,0.11223602,0.017101213,-0.013068535,0.043450657,-0.0015812619,0.0832089,0.0020125154,-0.023432612,-0.013922077,-0.04932243,0.10975694,-0.08334768,-0.038219318,0.14748868,0.032995317,0.03968298,0.09714702,-0.03280053,0.06498359,-0.036314417,-0.042913023,-0.00018170006,-0.034952782,0.046238888,-0.016311536,-0.034762744,0.008066358,-0.014984726,-0.020253655,-0.04148632,-0.038068645,0.0001766546,-0.012917022,-0.09276191,0.024004655,0.041016024,-0.038071904,0.010620716,-0.023029832,0.11192452,-0.025402514,0.05597413,-0.049708072,0.07651244,0.05918242,-0.00015561825,-0.0663958,0.046271257,-0.003275129,-0.07100676,-0.01917483,-0.03353448,-0.013834251,-0.025713786,-0.0045427084,0.036510658,0.05234508,-0.07362876,-0.058564726,0.038736906,0.04913411,-3.554775e-33,0.09706935,-0.12515628,0.07255868,-0.08338444,-0.06369877,0.05124684,0.012029419,0.033957608,0.05631678,0.031381074,0.02126068,0.00014709844,0.0070967004,-0.023092706,0.0028693334,0.024027651,0.075355895,0.0828462,0.011571978,0.0043264986,0.010176724,0.033393025,-0.048899215,0.043453634,0.04169415,0.103490256,0.012753661,0.05874442,0.012679659,0.020408656,-0.04119062,-0.03478074,-0.08593944,-0.05920865,-0.029717155,0.09451953,-0.08020495,0.11879454,0.007650169,-0.0768756,-0.04095107,0.05719816,0.07423699,0.05876727,-0.033506643,-0.026955664,-0.029061858,-0.035103954,-0.040792968,-0.07127363,-0.022756167,-0.0012829263,0.010254143,0.036189273,0.0101235835,0.07656768,-0.010218047,0.04398568,0.028434297,-0.05794288,-0.03348312,-0.13012202,0.05045549,-0.023663254,0.017680159,0.055207934,-0.0035513453,0.007669584,0.056882363,-0.060128756,0.016362311,0.05798251,-0.05646276,0.06959061,-0.09810976,0.041613024,-0.014334428,-0.05199613,-0.004079524,-0.043433566,-0.050192684,-0.056711182,-0.07329319,-0.08286262,-0.00271063,-0.03237971,0.16533145,-0.009547482,0.025193049,0.006594172,0.02476629,0.022750108,-0.03725336,0.02730079,0.048783023,-4.076723e-08,0.0061258418,-0.08954908,0.04832015,-0.07422592,-0.045535043,-0.0024887533,-0.00046612846,-0.10600503,0.07664651,-0.088899426,0.061877877,0.051547203,0.013438584,0.028554427,0.029908568,0.0043252455,-0.025750522,0.012012381,-0.020398127,-0.02648239,-0.07904655,0.022723848,-0.063279204,-0.004701107,0.04517881,-0.05343764,0.052403487,-0.00029565662,-0.0032986002,-0.006485621,-0.017071445,0.005898514,0.030556047,-0.019049522,-0.041384745,-0.012489835,0.025240097,-0.021934282,-0.036348633,-0.012255358,0.022390077,-0.04444064,-0.048225444,-0.037387896,-0.010264957,-0.04431372,-0.025759399,0.012369834,-0.0345058,0.010727274,0.09399165,-0.023995494,-0.067394264,-0.0453371,-0.14049955,0.0029325036,0.01578968,-0.018986797,-0.031521745,-0.022288127,-0.012586633,0.014821052,0.14981285,-0.025294801 +5.1.1.15,Contains pyridoxal 5'-phosphate. Also racemises 2-aminopentano-5-lactam (alpha-amino-delta-valerolactam) and 2-amino-4-thiahexano-6-lactam (where S replaces CH2 of C-4). It does not catalyse the racemisation of alpha-amino acids but has some transaminase activity with them.,384,0.99999994,0.0033491477,-0.030425254,-0.061886504,-0.07789025,0.036667325,0.10801012,-0.04266615,0.028323816,-0.02742241,0.036667645,0.0037524875,-0.10026236,-0.058537334,0.023090705,-0.043386437,0.00062192755,-0.041380245,0.04491077,-0.025755547,-0.035870958,0.0011987344,-0.0037045607,0.015176491,0.05629559,-0.015434033,0.105220094,0.040300302,-0.0053689177,0.06599339,-0.03685226,-0.052527618,-0.08392259,0.037217747,-0.041684985,0.019522024,0.041798707,-0.120237835,-0.033925977,0.051357765,-0.026111197,0.031133186,-0.04789003,0.0012840473,-0.0055372594,0.039949458,-0.02608315,0.03093484,0.022243483,-0.0033449058,-0.025123948,-0.028711582,-0.060732584,-0.027938258,0.0312633,0.017848715,0.09537461,-0.0018344639,-0.0016539568,-0.018996108,-0.009090326,0.020334084,-0.030615827,-0.028916152,-0.018565884,-0.011672749,0.009835109,0.014443512,-0.014761855,0.046127938,-0.06424996,0.009339208,-0.040520873,0.050444316,0.07814349,-0.02049675,0.049561076,0.026420029,-0.027660973,-0.00843437,-0.07741099,-0.0121601615,-0.07696544,-0.031091498,0.08976648,0.05138113,0.06219308,-0.02227865,-0.0024072698,0.047259394,-0.01608075,0.026125044,0.09243211,0.00034502035,-0.08432822,-0.054521766,0.08770754,-0.025174953,0.047333945,0.07131478,-0.02113859,0.026607616,0.06370062,-0.08754754,-0.033284873,-0.10216374,-0.0009226458,-0.043011904,0.03848194,-0.0032599894,-0.0021692943,0.007233361,-0.04099472,0.001250427,0.05677462,-0.0338979,0.020658882,0.068369865,-0.0017146677,-0.020832172,0.07291855,-0.028625544,-0.047675524,0.040864583,0.047432117,-0.040047165,-0.06780839,0.030284587,1.1031575e-33,0.06258213,0.0155528365,0.029212043,-0.013636725,0.009660137,0.034294445,-0.10103005,-0.016611839,-0.0664255,-0.07345277,-0.117837556,0.005697963,0.01141001,0.014326606,0.06061326,-0.051337708,-0.023765821,-0.03739141,0.043346696,-0.04107388,0.033378243,0.15780388,0.0022613797,0.06474333,0.019537428,0.012292021,0.041366436,-0.03836859,0.008151211,0.013872566,-0.07939177,-0.022780692,-0.13978675,-0.015241464,0.046682343,0.072017804,-0.0656056,-0.033210713,-0.025127588,0.12473528,0.00014045894,-0.028842773,-0.023602504,-0.011250169,0.027993536,-0.097334385,-0.026287608,0.0525214,-0.008656136,0.063782215,0.02364289,0.01556731,0.036755584,0.0035376546,-0.08107792,-0.03068056,-0.024161447,-0.007291696,0.025200652,0.11853387,0.038023967,0.034947116,-0.07003136,-0.016005913,-0.009963499,-0.018363861,-0.0321713,-0.052821815,-0.003752972,0.0048624384,-0.017493892,-0.05578091,0.07220915,0.07985562,0.048564427,-0.049105376,0.024615487,0.063154735,-0.003760003,-0.061191764,-0.027398787,-0.057182636,0.020324262,-0.011906197,-0.052648753,-0.031835753,0.046247773,-0.06772297,0.005507264,-0.043961458,0.022476712,-0.10536154,-0.118254654,0.07242507,-0.060044535,-1.9599337e-33,0.060979936,-0.12466546,0.029412325,-0.009766181,-0.025669258,-0.00064961985,0.08086102,-0.04613296,-0.013910531,-0.02676175,0.12145316,0.001952917,0.042448275,-0.036065474,-0.033759985,0.022752527,0.058670726,0.14655595,0.04341242,-0.020218266,0.068348676,0.07659383,-0.031582613,0.032426164,0.086886,0.045852907,0.03425145,0.04116424,0.01800509,0.06907499,0.024382515,-0.05758939,-0.019470602,-0.06228051,-0.056563504,0.053527106,0.014215481,0.031207845,0.0018655604,0.04854865,0.013088989,0.05147722,0.057796855,0.06694555,0.015823822,0.044981174,-0.0953867,0.05127959,-0.070565596,-0.04865826,0.16863889,-0.005018273,0.0046808985,0.010507803,0.058257602,-0.034805343,-0.019524088,0.024860675,-0.06490966,0.044247337,-0.03218365,-0.030763187,0.0068522147,-0.0055783647,0.08723035,-0.014349837,0.0042833444,-0.01177339,0.017292539,-0.034284383,0.037645835,-0.0004945662,0.047049478,0.019793421,-0.04769877,-0.00515209,-0.03065497,-0.021334432,0.057098642,-0.030001413,-0.0161995,-0.03804172,0.09608183,-0.015822629,-0.008668656,-0.00021179146,0.013550497,0.07733135,0.05265784,0.02457191,-0.015038653,0.013362666,0.018304037,0.09411156,0.13604574,-3.8833406e-08,0.088148795,-0.026021274,0.007338679,0.008198058,0.019492928,0.04783551,0.0061466773,-0.037666757,0.056468096,-0.07596993,4.7342422e-05,0.043954626,0.006828809,0.007590853,-0.001448444,0.0658557,-0.033551533,0.022198925,-0.03756027,-0.02467964,-0.12089558,0.0053879544,-0.05633873,-0.055203456,0.0021263296,-0.049275964,-0.028287992,-0.016529718,-0.017141707,-0.028552951,0.022770828,-0.037622415,0.055017088,-0.09679801,-0.003069013,0.10120471,-0.029943617,-0.037288945,-0.024444519,0.015348767,-0.041914247,-0.06602881,-0.04505675,0.022620821,0.019764047,-0.079470046,-0.042670865,0.038518395,-0.058385078,-0.044082753,0.048338775,-0.014179685,-0.038365934,-0.067759804,-0.09414341,-0.023361465,-0.02859133,-0.07300498,0.00869472,-0.086647585,0.021287136,-0.05297455,0.16979693,0.00925222 +5.1.1.16,"The enzyme specifically interconverts the configuration of Ser-46 of the peptide omega-agatoxin-KT, found in the venom of the funnel web spider, Agelenopsis aperta, but not that of the other serine residue, Ser-28.",384,1.0,-0.041505147,-0.0213499,-0.049049374,-0.0011907441,0.07706794,0.045382503,-0.02639121,0.047365732,0.017876836,-0.03459772,0.040303346,0.010178355,-0.04224313,0.057457946,0.009001691,0.04202675,-0.05917512,0.05105704,0.00828019,-0.024560547,0.10357956,-0.0023995228,0.016773893,-0.04188737,-0.04405632,0.0512186,-0.038218055,-0.026721625,0.02661841,-0.05653623,-0.06583689,-0.03580632,-0.016214617,-0.0529262,0.048487518,-0.0708912,-0.07815164,0.028846808,0.022802388,0.00062423124,0.044539895,0.062324703,-0.032500707,-0.023874035,-0.080909,-0.08386986,-0.105961405,-0.031214546,0.007131582,-0.015807305,-0.056449495,-0.11148037,-0.05597121,0.01002795,0.0489888,-0.029706249,-0.05018417,-0.08726114,0.041391425,-0.025673665,0.06410091,-0.008198338,0.017842228,-0.023486726,0.023449417,-0.06719274,0.04700487,-0.047154445,0.013158458,-0.079376556,-0.04100101,-0.11582832,0.017505765,0.093472704,0.003810717,0.016102375,-0.044179343,0.023411032,0.02638789,0.049627762,0.029334301,0.012120897,0.037609253,0.16570386,0.090212815,-0.015523852,0.008342989,0.0663723,0.04316966,0.03681235,0.028027225,-0.08296592,-0.048548285,-0.048260413,0.027827991,0.007691958,-0.035150062,0.11006312,-0.042871647,0.047240663,-0.022845041,0.024292886,-0.0603132,-0.043470908,-0.031216083,-0.004229338,-0.0069438186,0.112576075,0.030492313,-0.023819761,-0.046995606,0.0012819411,0.035109933,-0.018145114,0.005579813,-6.6343014e-06,-0.025980223,-0.03619199,0.04080019,0.02147344,0.030832134,0.026533661,0.02230236,0.056646362,0.09077165,0.048558637,-0.12236467,-6.503574e-34,0.08783076,-0.009242814,0.032515988,-0.049944017,-0.0093124565,-0.052451264,-0.02324236,-0.0033500171,0.004454209,0.031275146,-0.09771995,-0.04972765,-0.011965698,-0.036162492,-0.053355962,-0.0063563767,0.027563678,-0.0071804663,0.033133376,-0.07876913,0.08912815,-0.009650318,-0.039526336,-0.02316852,0.0051449183,0.0201239,-0.1290713,-0.0092765605,0.04394152,0.054338142,-0.022566082,-0.08519976,-0.06137301,0.09914261,0.02307781,-0.02848887,-0.023532946,-0.0736759,-0.076127216,0.026075518,0.012376538,0.05725909,-0.006203779,0.0037586715,0.0424122,-0.06353255,-0.051204108,0.11325709,0.084485315,0.05052746,-0.044495985,-0.0018264082,0.041055225,0.021568254,-0.04348971,0.06676427,0.029910665,-0.03218838,-0.05519982,0.025227305,0.033635955,-0.03274221,-0.012427777,0.018796084,0.1371357,0.053138603,-0.03469675,-0.008097041,-0.0043760464,0.06588402,-0.06582272,0.041535217,0.05715031,0.008999448,-0.009809853,-0.0934127,-0.02857831,0.04464818,-0.050849646,0.01616197,0.040496036,-0.060644545,-0.0204559,0.03166332,-0.04035682,0.013670588,0.04994243,-0.08402212,0.02562762,0.025806524,0.006203228,-0.08196943,-0.049669944,0.00054576946,-0.06699254,-2.4949147e-34,-0.008128986,-0.0010376849,0.065417156,-0.04575465,-0.072497256,0.06528948,0.025479881,0.07112182,0.011211651,0.054902546,0.059393704,0.011577613,0.05134268,-0.06930682,-0.030312711,0.044171482,-0.01087602,0.02740166,0.076320894,-0.034955155,-0.04892115,0.024764547,0.022457095,0.048644096,0.11405577,0.041100908,0.10843349,0.089998566,0.012483294,0.050723985,0.044971716,0.084231876,0.06331342,-0.038112346,-0.06704611,0.0042796494,-0.042629134,-0.050024975,0.026008464,0.009023007,-0.03380446,0.0033526176,0.037921727,0.06831021,0.029294698,0.040117342,-0.027067853,0.07074941,0.1007052,-0.15466289,0.004986808,-0.018630827,0.011583635,-0.031142293,-0.07532522,0.058708936,0.004309716,0.030441562,-0.021280073,-0.014735891,0.049425643,-0.02408383,-0.060203884,0.036493428,0.05588696,0.045735523,-0.062840916,0.01047192,-0.031879812,0.03469524,-0.06453694,-0.025958851,0.018264433,0.0049583158,0.05323468,-0.069804646,0.0062258635,0.020234877,0.01137969,-0.018061664,-0.030798893,0.07785776,-0.049749643,-0.091124974,0.022358935,-0.044429302,-0.058597226,0.121157974,-0.032324284,0.03691532,-0.10943546,0.020706683,-0.091167696,0.06680002,0.034542285,-2.8216148e-08,0.10428738,-0.031320088,-0.018031226,0.016590081,0.0135974465,0.021294024,-0.074515,-0.018026963,-0.0071248505,0.021200584,0.00376877,0.08561256,-0.0023374378,0.00091040996,0.010641705,-0.0507675,-0.034414425,0.030338308,-0.035997625,-0.0642192,-0.020211624,-0.013273152,0.017111631,-0.0011921612,0.028304169,-0.01240687,0.00043354425,0.05774899,-0.029690448,0.042099647,-0.017130965,0.005544942,-0.0028974132,-0.01995704,-0.08852526,0.030319272,-0.09222414,-0.09893235,0.02298885,0.01504082,0.052033123,-0.057458602,-0.07751302,0.032972928,0.02895682,0.016107364,0.0035251144,0.03619729,-0.041230943,-0.04360389,0.036631178,0.01615665,-0.027288357,-0.04963998,-0.04267461,0.02195395,0.053474735,-0.0949894,0.0133979125,-0.037088852,-0.008482187,-0.07244388,0.15376441,-0.025668316 +5.1.1.17,"This enzyme contains pyridoxal phosphate. Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, deactoxycephalosporin-C synthase, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway (for pathway, click here).",384,0.99999994,-0.052526243,0.014817481,-0.04319365,-0.08931041,0.08108727,0.009778169,-0.017882256,0.022022989,0.06128648,-0.03449364,0.0401554,-0.075615145,-0.039332636,0.073286876,-0.07643885,-0.05883132,-0.07989653,0.024570717,0.00702903,-0.05916574,0.051519547,0.005685175,0.013669781,0.013823574,0.037729833,0.02213904,0.09901177,0.003391818,-0.009404351,-0.09437701,0.048437368,-0.024882765,0.043551415,-0.11141122,0.084370956,0.04053971,-0.073255755,-0.045525674,0.10973301,0.0025425728,0.028110508,-0.027014522,-0.0009488331,0.01382139,-0.0040231445,0.01856923,0.008084683,0.07232712,0.04672719,-0.06404508,-0.0027003007,-0.07450269,0.0032209666,0.027986204,-0.0030413158,-0.004840421,-0.03295786,-0.04607895,-0.04941476,-0.07082902,0.059159227,0.012792614,-0.00012917785,0.0067206672,-0.08648427,0.006676562,0.06009234,-0.11136958,0.0068268613,-0.0049897637,-0.11865929,-0.03731435,0.053871915,0.10171511,-0.012818253,0.04223867,0.025071302,-0.03545586,-0.01278912,-0.007771682,0.084727205,0.012646594,-0.02855048,0.072379895,0.0656304,-0.056230746,0.06880322,0.03439523,0.05665668,0.0051285876,0.04009428,0.058781166,-0.051053338,0.022740686,-0.0760668,0.03675581,0.0014981034,0.104204774,0.009686011,-0.053449724,-0.056821957,0.08043391,0.010152096,-0.03989944,-0.06660057,-0.020288164,0.008405424,0.061825693,0.0012006547,-0.018066535,-0.029683745,-0.06761477,-0.0052136313,-0.047776777,-0.0041438984,0.07108232,-0.013125783,-0.017793765,-0.0077080596,0.06276976,0.02154616,-0.013298217,-0.01912542,0.053560276,-0.09309113,0.0014388702,-0.07614305,2.903916e-33,0.011014327,0.05732337,-0.03598385,0.009351562,0.05876671,0.00046265285,-0.0080511905,-0.0046236264,-0.0605533,-0.110044576,-0.041134283,-0.07539757,-0.0067434814,0.04809593,-0.0640302,-0.04638267,0.016640197,0.017801393,0.024375144,-0.008536931,0.065777026,0.040770456,-0.10638354,0.006288796,0.07292829,0.075640075,-0.0412492,0.06473094,0.088143,-0.019845404,-0.0069521884,-0.04246711,-0.08995669,0.007834158,0.07101912,-0.031731475,0.022610243,-0.036417075,0.03606765,0.08837598,0.02022703,0.009206907,-0.002744391,0.0028465667,0.06368431,-0.029680202,-0.074751094,0.067079365,0.06799198,0.003368976,0.12064834,-0.03141983,0.028168222,-0.046607357,-0.0159845,0.0027045927,-0.089120485,-0.014553603,0.022135317,-0.013171455,0.068465605,0.07233087,-0.06438562,-0.015881808,0.019045994,-0.015999084,-0.019859524,-0.04828264,-0.0058877207,0.03501361,-0.07431196,0.01436597,0.027428748,0.08170783,0.025165435,-0.010578704,-0.05195177,-0.026667653,0.040647633,0.004569456,-0.020817662,-0.032095183,-0.029647285,-0.05253294,0.0013627883,-0.03285476,-0.043248627,0.007518669,0.0021693273,-0.0017135456,0.0038626431,-0.090996996,-0.07826679,0.059706066,-0.064130515,-4.3675544e-33,0.1474399,-0.054670177,0.026905704,-0.046879575,-0.088916115,0.105751306,0.0102871,-0.04888579,0.12513185,0.04989774,0.035363033,-0.07979503,0.004441146,-0.055190627,-0.03824887,-0.008811766,-0.021885091,0.08592807,-0.056388382,0.025217216,-0.012144922,0.0067259963,-0.044330426,0.024129435,0.040363893,0.022711182,0.0110426275,0.086118974,-0.01642135,0.055796083,-0.030811923,-0.049366046,-0.018247852,-0.004822073,-0.11946843,0.087889984,-0.029000122,-0.01696921,0.026396224,0.00344064,-0.019766755,0.007163072,1.5050093e-05,0.040370356,0.0029155423,0.040900588,0.0021114356,0.04707167,0.042257007,-0.048657164,0.044716332,0.021874515,-0.0127346,-0.007357608,-0.027737783,0.03829775,0.037265237,-0.013208459,0.09130262,-0.038815532,0.03414307,-0.06493746,0.021266771,0.020376896,0.05567646,0.017959932,-0.077526696,0.08495255,0.084669,0.00482981,0.013655435,0.008373731,0.009462645,-0.008470094,-0.05878006,0.053797927,-0.017951779,-0.036485102,0.071352616,-0.03949156,0.018561762,-0.04106106,-0.0038394025,-0.06953086,-0.047648493,-0.009366315,0.044064634,0.019187449,0.013520465,0.05662197,-0.0064576883,-0.01914131,0.01602834,0.08434205,0.049096048,-4.1653163e-08,0.1013847,-0.007968267,0.017069288,-0.016190616,0.026363105,0.0054517174,0.0598328,-0.059083078,0.09689859,-0.025409812,-0.058166765,0.012334825,0.011195002,0.03204138,0.013811707,0.059937276,-0.049749337,0.062866084,0.01695229,0.0023711969,-3.762243e-05,-0.01047791,-0.10550069,0.021017725,0.05914915,-0.052419662,0.047964636,0.08248062,-0.06356358,0.0038106611,-0.03892524,-0.014733714,0.014969223,-0.03417129,-0.025658363,0.02542812,-0.11916957,-0.06105539,-0.05785634,0.03127664,0.022806533,-0.04714461,-0.05701068,-0.060152434,0.014897537,0.0065749334,-0.011660372,-0.037109904,-0.074193574,-0.023172991,0.08675262,-0.054567583,-0.028954627,-0.043080512,-0.11646981,0.07487987,-0.026681626,-0.029582763,-0.035464704,-0.11780489,-0.079675205,0.030970303,0.1756074,0.02865997 +5.1.2.1,"The enzyme has been characterized from the bacterium Lactobacillus plantarum and appears to be restricted to lactic acid bacteria. It contains a unique nickel-containing cofactor, pyridinium-3-thioamide-5-thiocarboxylate mononucleotide Ni pincer complex.",384,1.0,-0.032620795,-0.08869338,-0.07099959,-0.048302945,0.04019563,-0.011910046,-0.038815495,0.028092401,0.0008798217,-0.031912487,0.028114913,-0.084025964,-0.09459361,0.040720496,-0.036459513,-0.055586316,-0.08345367,-0.0116146365,0.059247736,-0.0285953,0.032435365,0.055214576,0.00065403257,0.0047568656,-0.02822673,0.047825627,0.08547951,-0.043401957,-0.039384857,-0.07912268,-0.02615236,-0.102674335,0.0719277,-0.03013189,0.06972026,0.014322805,-0.017687045,-0.026751405,0.046412446,1.8244675e-05,0.06251871,-0.009009992,0.11163007,0.0297794,0.04293215,0.05585487,0.0732938,0.01855251,0.018837499,-0.019962579,-0.06574535,-0.0355995,0.052846644,0.0189779,0.022231426,0.013378432,0.018357834,-0.0791356,-0.007991008,0.025730183,0.111108996,0.02662929,0.080428384,-0.02285847,0.031615246,0.041905206,0.02423834,-0.06963056,0.007841297,-0.057720177,-0.03122453,-0.081554666,0.017456762,0.020074958,0.00043181572,0.031428974,0.014013807,-0.05249478,0.08772322,0.017571792,-0.037853103,0.027002636,-0.016413983,0.09779319,-0.046298854,0.010263962,0.09476789,0.07297111,-0.0083964355,-0.034392264,-0.03951729,0.011032098,-0.0496988,-0.06368625,-0.12445678,0.0013687442,-0.07951261,0.046994183,-0.008730842,-0.05410766,0.044701483,0.044293337,-0.0015096527,-0.10790662,-0.10824471,0.019419823,-0.010837342,0.06353456,0.063517116,0.06324692,-0.019526945,0.047959603,-0.01653569,-0.023437453,-0.018592302,0.03240812,0.044654593,-0.0634222,-0.025008554,0.079077624,0.04277145,-0.04912275,0.04909986,0.016280714,-0.07897481,0.029465081,-0.042759474,4.6663823e-33,0.0032587838,-0.0076416046,0.007403379,-0.091652356,0.047879994,-0.035998404,-0.09696761,-0.045887984,-0.08514342,-0.0045096837,-0.025957054,-0.0761631,0.008283821,-0.016893921,-0.015917476,0.051572792,-0.08314804,0.052410807,0.03052355,0.034411136,-0.0060501797,0.090281345,-0.087545216,0.06366776,0.07897183,0.093658134,0.03779744,-0.019794915,0.070546634,-0.026011908,0.10592383,-0.14441127,-0.058675714,-0.00022965763,0.11045362,-0.029428497,0.014981023,0.022972006,-0.012684138,0.037833113,-0.023660267,0.04487551,0.036050804,0.04338911,0.028430408,-0.026753493,-0.044632547,0.05933067,0.02157898,-0.035295535,0.04319898,-0.041098908,0.02470399,-0.020623812,-0.013243256,0.01564589,-0.046519637,0.12330405,0.070599124,-0.047128823,0.03885306,0.03131507,-0.054731876,0.029448347,0.02772639,0.04316905,-0.03624054,-0.026545797,0.09732749,0.06019731,-0.080058716,-0.034452785,-0.028048458,0.0014253217,-0.0011767133,-0.051811565,-0.0420609,-0.01761865,0.0020186184,0.007026378,-0.071136795,-0.054678503,0.032845527,-0.033069227,-0.048891824,-0.03420573,-0.093769,0.009298961,-0.027924761,-0.020765744,0.044670735,0.01397973,-0.06099165,-0.0070434427,-0.01524237,-4.7527753e-33,0.045896195,-0.093077555,0.054586038,-0.04975711,-0.05025806,-0.00019754225,-0.005816538,-0.005429027,0.021468604,-0.025363848,0.078519136,-0.05473412,0.031767126,0.020084068,0.03342676,0.037914142,0.012866645,0.10625858,0.02800772,-0.0062601794,0.005365878,0.04951536,-0.030284807,-0.051587213,0.002248715,0.1047195,-0.07079393,0.04313253,0.04635644,-0.013361268,0.030963616,0.05525708,-0.050102964,-0.10012405,-0.08570856,-0.032572653,-0.02007356,-0.06691142,0.026667235,0.00090438075,0.0011412186,0.029840002,0.010476466,0.039198976,-0.041014545,-0.010716204,-0.06263934,-0.0012602021,0.035533253,-0.008418504,0.017869359,0.01278468,-0.015156285,-0.045306586,0.024835307,0.09411862,0.0015750985,0.0036749928,-0.0037219117,-0.043527387,-0.07519063,-0.07887276,0.07840269,0.0009825965,0.037670914,0.017734766,-0.020274404,0.01681692,0.06354078,-0.084229864,0.027678391,0.11702965,0.06944028,0.08227293,-0.0638621,0.017287772,-0.018459246,0.0016791209,0.028090248,-0.013818489,0.03882639,-0.019908305,-0.01898752,0.0031225788,0.07032131,-0.020832956,0.02579403,0.103697695,0.00012967548,-0.0117661245,-0.031789422,-0.0018284789,-0.08043232,0.029402707,-0.04170375,-3.606896e-08,0.06267158,-0.06950808,-0.0298862,-0.07722206,0.0141549,0.06046895,-0.010628308,-0.03271794,0.036902267,-0.0072979527,0.09778389,0.099949814,-0.09411999,0.003197524,0.042176344,-0.016511539,-0.01610658,-0.06525026,-0.023574071,0.057640243,-0.032522414,-0.015491246,-0.10809255,0.032505076,-0.03761202,-0.0058863466,0.07305979,0.0167287,-0.042385906,0.0008938337,-0.027324904,0.058799606,-0.015260534,-0.019280273,-0.034580663,0.04397332,-0.0707345,0.041834164,-0.04224461,0.04451306,0.038123596,-0.031895664,-0.07225111,0.007983424,-0.011112455,-0.039064247,-0.025604853,0.019390691,-0.042324122,0.0056071747,-0.06679293,-0.0005283091,-0.033510186,0.033601947,-0.054052103,0.062204782,0.061144594,-0.08738008,-0.038930524,-0.0019305809,0.07187737,-0.032974347,0.1855215,0.03545127 +5.1.2.6,"(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate is the commonly occurring isomer of isocitrate.",384,1.0,0.00057950406,-0.11284806,-0.028587624,-0.0227809,-0.021320254,-0.028856017,-0.0128096705,-0.043212757,-0.017450972,-0.07780902,0.15437797,-0.11268477,-0.08231146,-0.027842214,-0.046225797,-0.023550281,0.048420444,0.034405008,0.04165007,-0.008937523,-0.029519372,-0.008518581,0.0023799825,0.07107382,0.04815715,0.003566821,0.0004646495,0.0009495296,0.047571637,-0.082589775,0.07795039,-0.065727,0.007365416,-0.034194876,0.012118503,-0.031158049,0.005189508,-0.059002392,0.04406076,0.056192666,0.04893826,-0.057424724,0.055504814,-0.024661958,-0.07826842,-0.007721407,-0.017352143,0.0033723842,-0.00011421532,-0.05890666,0.043486957,-0.039206855,-0.085983284,0.05191641,-0.021964535,-0.07858166,0.08800959,0.072208695,-0.016581262,-0.020069275,0.0016401416,0.024514968,0.02847379,-0.018848063,0.01284974,-0.016480453,0.07265157,-0.017793205,0.04459893,0.008898482,-0.07167549,-0.05356114,-0.031816807,0.018381404,-0.030454691,-0.08702975,-0.07011105,-0.021395283,0.05534741,-0.023919413,0.0073154056,-0.07093431,0.00038585413,0.0055163456,-0.037045363,-0.02144554,-0.053078283,0.070296794,0.02572705,-0.020709151,-0.06352041,0.07439888,0.055384036,0.0072890054,-0.05816243,0.046222195,0.018948803,0.06974106,0.042665403,-0.029602187,0.038630176,0.009738627,-0.13714199,-0.047940433,-0.013740196,0.03723815,-0.010193689,0.028276298,0.056870535,0.12609556,-0.09333431,0.004974409,0.005163695,0.0017704727,-0.05294338,0.020809585,-0.019936245,0.021440003,0.07709249,-0.042539723,0.046185423,-0.08082848,-0.027598232,-0.0047451025,-0.07947987,-0.024755077,0.05115791,4.712599e-34,0.007120082,0.07813632,0.021712972,0.061852187,-0.0620127,0.02771909,-0.036649596,-0.02414873,-0.050335657,-0.030336298,-0.112099536,-0.041638136,0.011958716,0.06727517,-0.08567915,-0.11393568,-0.063388154,0.05494034,0.07062273,-0.060007527,-0.03263551,0.11326428,-0.06921243,-0.005902648,-0.022963645,-0.024640186,-0.043616228,0.0023694078,0.01732348,-0.016770069,0.043027204,0.024878364,-0.07686475,-0.02677227,0.05094903,0.029895533,0.017061325,-0.018022532,-0.0024120791,0.023902135,0.029486218,-0.04095288,0.014405499,-0.0992868,0.098937005,0.0072958022,-0.0086689815,0.05509418,0.00053699024,0.034460224,-0.010128198,0.011976988,0.03726948,0.007314267,0.023173317,0.016691629,0.011905571,0.01526463,0.01676929,0.05435332,-0.032682635,0.12506211,0.064390495,-0.040388756,-0.025669986,0.019549724,-0.09685449,-0.029127667,-0.0013126316,0.03758831,-0.021172708,0.023341158,0.049421024,0.02143566,0.06700702,-0.046232592,-0.041006904,0.013355316,-0.0035956455,-0.010331648,-0.11396895,0.057946634,0.009847173,-0.0037393328,-0.102571554,0.016034756,0.0009848815,0.073386654,-0.028279025,0.08814111,0.034184687,-0.0072570997,-0.060817424,0.038290657,-0.0045775804,-2.1590997e-33,0.038943022,-0.040153347,-0.013609382,-0.04231094,0.013334993,-0.014969939,0.0274909,0.046957534,0.024234809,0.022598349,0.09731888,-0.06852739,-0.02159825,-0.05095927,-0.010462655,0.010802277,0.010086071,0.02577357,0.010591602,0.00968015,-0.0031696951,-0.02475509,0.040038917,0.11596736,-0.031622697,-0.015630048,0.079327345,-0.026203554,0.07255697,0.099017516,-0.029307859,0.00506717,0.049878877,-0.04306892,0.0025858602,0.08135825,-0.0077174786,0.0019416022,-0.09164438,-0.037118778,-0.09443494,0.06607016,0.014231838,0.039742127,0.030963913,0.026098425,-0.026548347,-0.029768722,-0.053539418,0.036221772,-0.038707856,0.0017197296,-0.027427008,0.050714005,0.05492501,0.08211461,-0.1460021,0.05148655,0.02335966,-0.03549642,-0.0032176247,0.022596061,0.0287008,-0.036934476,0.09216156,0.0076076123,-0.029948678,0.015118262,0.006247147,0.0061944257,0.19123442,0.041955277,0.01486055,0.007779076,-0.0073387753,-0.1505048,0.0017724017,-0.066956215,-0.08406737,-0.0287459,0.059981436,-0.005128475,0.055726554,-0.04206048,-0.06059893,-0.094296075,-0.0043408023,0.04591641,0.025513576,-0.013344631,0.026511693,0.025176538,-0.058150817,0.039254595,0.01891263,-3.140499e-08,0.011275613,-0.025089301,0.022361709,-0.044712424,-0.038161647,0.09687287,0.014840787,0.005207107,-0.00027099485,-0.05316812,0.08130367,0.038600266,0.00090648024,0.0072822147,0.09053084,-0.002172041,-0.057367537,0.09911274,-0.018992294,0.010858681,-0.023666667,0.040064216,0.0111353835,-0.07788078,-0.027296167,0.07096581,0.08236338,0.030014321,0.046119463,-0.031431366,0.008103431,0.009218827,0.0021161889,-0.0315924,-0.0015746024,0.10767939,-0.078602694,0.048036948,-0.029743876,0.052195445,-0.06006119,-0.040440254,-0.061906163,0.002620638,0.119000636,0.015595846,-0.050298426,0.029891577,-0.015472346,-0.063596174,-0.007097858,-0.005443843,-0.036161754,-0.010836136,-0.021838803,-0.0199878,-0.087775886,0.037998788,-0.033110455,-0.032890692,0.06252878,0.029867476,0.114074945,0.045952406 +5.1.3.1,The enzyme also converts D-erythrose 4-phosphate into D-erythrulose 4-phosphate and D-threose 4-phosphate.,384,1.0,-0.0071437997,-0.008851301,-0.038692847,-0.024355741,0.0006626065,-0.0056547993,-0.021115439,0.010760401,0.032471646,0.0575437,-0.03991166,0.037438825,-0.07985934,0.021665247,-0.008942783,0.008987294,-0.0114827445,0.11892645,-0.06361984,-0.04855944,0.11661514,-0.034836452,0.0043427614,-0.04753019,0.104394935,-0.034536667,0.058694344,-0.049521204,0.0034530929,-0.06658629,-0.03099212,-0.10256058,0.017536923,-0.021864893,0.02834428,0.09301903,-0.023951676,-0.024721026,0.00048842374,-0.023519056,0.07625145,-0.02507299,0.010820515,0.04178662,-0.11008028,-0.005126933,-0.05397087,0.02492694,0.05333608,-0.02336959,-0.040293343,-0.018160181,-0.11059603,-0.049724963,0.028645622,0.059148245,0.001137491,0.05645739,-0.005048842,0.07366987,0.05342904,0.034075268,0.012588193,0.024665155,0.05269607,-0.04758999,0.05168773,-0.022063632,-0.047899507,-0.095118076,-0.03211602,-0.026224481,-0.015443025,0.02930592,0.050960008,-0.043963917,-0.060660478,0.028274992,0.031190857,0.014444925,0.08968473,0.07199328,0.02710706,0.04801292,0.01391778,0.08361215,-0.054629523,-0.006309856,0.041390546,-0.024247272,0.0006592114,-0.08610178,-0.037812535,0.01530023,-0.03681594,0.025942441,-0.02768973,0.002931125,0.0726332,-0.03997362,0.026045375,0.08022505,-0.054760516,-0.103880726,-0.027674709,0.011240587,-0.0024472512,0.09749824,-0.014777032,-0.0042583495,0.020713069,0.025712086,0.09525154,0.10975286,-0.06422791,0.0750745,-0.043997984,-0.06259287,-0.05416633,-0.0024786845,0.012361294,-0.0016826213,0.08377006,0.071456335,-0.007038825,0.022692772,-0.06385282,1.5369261e-33,0.036009975,0.07530929,0.038809683,-0.0029457223,-0.010776013,0.028129488,-0.057140622,0.0097642895,-0.0656123,0.0037962056,-0.08378869,-0.11433719,0.054516077,0.04161853,-0.07184017,-0.004626868,0.011647961,0.047757648,0.07797008,0.04715832,0.0133305825,0.08000582,-0.07721402,0.07501766,0.0027581234,0.06641632,-0.048359603,0.1050679,0.07869453,-0.01703328,-0.018961962,-0.09495008,-0.06592629,-0.0063935956,0.0065592015,-0.048401028,-0.046390187,-0.016392516,-0.005255334,-0.0068611484,-0.04140045,0.01219257,-0.026074946,-0.020835668,0.038544014,-0.055130538,-0.02946518,0.04335563,0.04975266,0.05591954,0.02469578,-0.017622413,0.11667534,-0.020750085,-0.09859465,-0.011312364,0.0126598505,-0.02008145,0.07668679,0.018232217,0.030675184,0.023641389,-0.04778874,-0.0085739745,0.102768786,-0.010153112,0.014859879,-0.096503906,-0.047951426,0.09765889,-0.024360936,-0.06440627,0.047033515,-0.0037699305,0.019597657,-0.07677102,-0.043953955,0.017986853,0.018967038,-0.06476967,0.0058644973,0.03636945,-0.012525307,-0.053652644,-0.01215943,-0.021172369,-0.019794827,-0.063145176,-0.0038239697,0.06523267,0.0463731,-0.10686216,-0.08881769,0.010384582,0.027763758,-1.8283125e-33,0.07055886,0.03126264,-0.021027176,0.0007317137,-0.029417118,0.0010591643,0.07898697,0.014112205,0.054596554,0.02172794,0.11486293,-0.046160605,-0.028577158,-0.01798028,-0.0041244696,0.07272263,-0.0350063,0.011739375,-0.041420072,0.016537184,-0.00783735,0.10172751,0.03142902,0.057335727,0.08424858,0.0076397844,0.040909406,0.04745474,-0.011284935,0.033915058,0.033413693,-0.07256835,-0.060399864,-0.00203535,-0.13411258,-0.00071891525,-0.008768087,0.007499273,-0.040008545,-0.01597435,0.031741984,0.033890516,0.065888904,0.029697178,0.0073783705,0.04051951,-0.028037662,0.071378246,-0.0061290604,-0.0422287,0.019935727,0.05294865,-0.023243649,0.01685481,-0.014084507,0.018199718,0.09002907,0.010898877,-0.0976035,-0.036112614,-0.10680595,-0.095370464,0.11079525,-0.020206654,0.025975559,0.03666912,-0.051855482,0.056378268,-0.00642496,0.019250663,0.03580198,-0.01289386,-0.004556978,0.015680388,-0.022246378,-0.07495946,-0.08918895,-0.023727225,0.004927387,0.0020500976,-0.04315817,0.0012058077,-0.039137952,-0.058283918,-0.03160182,-0.099847026,0.015814876,0.10104874,0.009651602,0.07711328,-0.007229978,-0.021756876,0.003965767,0.03637818,0.111946,-2.8245616e-08,0.036130562,-0.023277791,-0.010828678,-0.059784204,-0.018511143,-0.054636925,0.0051761447,0.086348645,0.0044311355,-0.02368469,-0.081053026,0.084197246,-0.04286899,-0.007076355,0.10335118,0.023646988,-0.034086477,0.028784925,-0.023245355,-0.02381548,0.007903765,-0.031168904,-0.13196258,0.048685845,0.03596412,-0.03644254,0.0017717899,-0.019353803,0.025286077,0.01316617,0.01852979,0.017863145,-0.0033841776,-0.073435836,-0.067601204,0.013806456,-0.076699466,-0.002441065,0.01627867,0.014580148,-0.004249912,-0.043377087,-0.026569923,0.03932146,-0.053088106,0.0313625,0.0077461316,0.016716875,0.020657739,0.008090734,0.015074057,-0.041380454,-0.06573249,-0.10279992,-0.08510512,0.034571335,-0.007004785,-0.024655199,0.033081606,-0.02702377,0.033998527,0.056590535,0.17434593,-0.060627196 +5.1.3.2,Requires NAD+. Also acts on UDP-2-deoxyglucose.,384,1.0,-0.09951316,-0.014798264,0.011139643,-0.022915395,-0.0034490102,-0.006604545,-0.041161496,0.026282318,-0.0073688542,0.041393377,0.04328405,-0.0124907475,-0.09029963,0.09302847,-0.020418338,0.040818155,-0.0033575073,-0.0075781844,0.052728098,0.021445043,0.064237766,0.015991785,0.008964832,-0.050376456,0.08986807,0.014739647,0.032098386,0.031330876,0.049760498,-0.08905648,0.009733729,0.009063407,-0.047268353,-0.06159395,0.016865984,0.09397669,-0.06987971,-0.018245606,-0.042476606,-0.010037146,0.07349978,-0.021700598,-0.053088397,0.06506247,-0.018146029,-0.07992193,-0.023652015,0.06845075,0.027681176,0.0034391198,-0.02957894,0.03213776,-0.030202316,0.04936845,0.034499913,-0.030415235,-0.050639313,0.010119346,-0.028808132,-0.051335625,-0.04244486,-0.049780127,-0.036935255,0.016528087,0.08044192,0.016651427,0.09673025,-0.03262883,-0.071285106,0.04604843,-0.08449129,0.011346942,-0.031683832,0.039684612,0.0033466064,0.086620845,-0.091613404,-0.09441223,0.083468,-0.0027569884,0.007547778,-0.00034537082,-0.038776387,0.047832035,0.07601661,0.019623933,-0.039846707,-0.03915831,-0.07797462,-0.011678491,-0.035858884,0.030050319,-0.02308122,0.09136729,-0.083387546,0.034992818,0.060023077,0.05511105,-0.015880948,-0.02174884,-0.0656695,0.08519598,-0.079173975,-0.07198668,-0.050837655,-0.023614533,-0.00343666,0.014350984,-0.060635433,0.032634366,-0.019051993,-0.004378226,0.069996335,-0.024586394,-0.023041647,0.10520853,-0.008308613,-0.012774378,-0.039829686,-0.09851858,-0.01182261,-0.04916352,-0.0042343214,0.026040474,-0.04266983,-0.012522123,-0.0053187953,-3.998765e-34,0.09679083,0.017854927,-0.0387694,0.070420675,0.0075295633,0.040267248,-0.08187065,0.020077372,-0.08355337,0.0030141417,-0.08614694,-0.11795757,0.066463426,0.06129649,-0.0051865703,0.030878227,0.029771987,-0.054369655,-0.010776413,-0.0078079468,0.056517735,0.06457854,-0.021686122,-0.012154054,-0.0108659975,0.06803256,-0.036265768,0.03792433,0.06169514,0.0063377465,0.026091687,-0.08821406,-0.09755133,0.041465044,0.07335813,0.03563072,-0.093303494,-0.027892113,-0.031851206,0.010407858,-0.05626648,0.030814951,-0.049768157,-0.05638655,0.0602122,-0.07576715,0.010170654,0.04506636,-0.022866402,0.05193302,0.04485364,-0.0016958597,0.058549535,-0.016675027,0.014478378,0.010067528,0.03238764,0.024724916,0.004355032,0.14441416,0.015939984,0.046376854,-0.018317513,0.012924497,-0.051240526,0.008282778,-0.11628025,-0.06020233,0.021971608,0.010307948,0.022197813,0.054012336,0.062655285,0.02206981,0.024009805,-0.031143144,0.024587829,0.010849509,0.079581894,-0.0006159837,-0.043675456,-0.05486369,-0.036753964,-0.0095800245,-0.02891747,-0.028403962,-0.021361642,-0.030096311,-0.023754552,0.07189485,0.02367678,-0.036752246,-0.011974658,-0.06525748,0.033639204,-2.3400777e-33,0.03807811,0.00017671226,-0.010262812,-0.049330518,-0.0107299965,0.05681729,0.064764656,-0.08714774,0.05982658,-0.04404482,0.047210727,0.038602963,-0.019427545,0.0047679483,0.08083254,-0.0019694678,-0.08147405,0.0030180416,-0.03451304,-0.005994776,-0.00034829596,0.19798094,0.019387072,0.07276925,0.059705596,-0.020549413,-0.039960243,0.05545547,0.027347963,0.029301979,-0.008974337,0.009959461,-0.11830685,-0.060660113,0.017107755,0.045664914,0.020715358,-0.002566637,-0.06889835,0.015801713,0.034542702,-0.0094017,-0.106322594,0.09327639,0.08816239,0.026817914,-0.031441905,-0.047004882,0.007436642,0.008988982,0.03913121,0.0044773873,-0.045943066,0.014797181,0.038463496,0.061026104,0.034266055,0.005381947,0.06434284,0.004078338,0.0123451,-0.08558171,0.0036640689,-0.06591795,0.05948818,0.014724923,0.01095108,0.022630613,0.087151356,-0.042144634,0.039668474,0.06695531,-0.012025363,-0.004473284,0.009360071,-0.032167155,-0.13096692,0.018809764,0.014020768,-0.027046097,-0.07733679,-0.0059970096,-0.013831086,-0.0099979965,0.064583935,-0.08201339,0.03857376,-0.0062419204,-0.0764966,0.014292279,0.001222449,0.037836988,-0.031135641,0.10546807,0.008657429,-2.348359e-08,0.02589369,0.034310374,0.01856617,-0.069299266,0.014298979,-0.006275768,0.06466729,-0.0026103181,0.02693097,-0.027308302,0.0064026574,0.12340531,0.04507034,0.0383234,0.0982022,-0.028792812,-0.05118113,0.0060618115,-0.09480587,-0.10971078,-0.057454783,-0.04385215,-0.14120558,0.09453794,-0.04190038,-0.05888062,0.09744957,-0.004170906,0.07571498,-0.043320104,0.043414727,-0.0072225556,0.014384024,-0.050951008,-0.08762753,0.059114672,0.011191305,-0.008830013,0.0012284878,0.05595912,-0.07550295,-0.0250847,-0.04397484,0.020493438,0.017238552,0.029930629,0.0094439015,-0.022077626,-0.0767931,0.020225435,0.026926573,-0.040341318,-0.030141234,-0.06307246,-0.03392842,-0.008514554,-0.024127504,0.0011740432,0.034198523,-0.078707136,0.020221911,0.022026554,0.10332115,-0.05053485 +5.1.3.3,"Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. This enzyme catalyses the first step in galactose metabolism by converting beta-D-galactose into alpha-D-galactose, which is the substrate for EC 2.7.1.6, galactokinase [5,6]. ",384,1.0,0.0004079531,-0.083064094,-0.012029881,0.0123474775,0.07128188,0.04128282,-2.2585264e-05,-0.0426608,0.00530951,0.054549266,-0.0179659,-0.01938226,-0.09953199,-0.0026012247,-0.006483006,-0.0044849147,-0.030184954,0.04102286,-0.0067814155,-0.0060816165,0.1340183,-0.030232362,0.013109362,0.010765112,0.0739317,-0.02317714,0.060013123,-0.06702877,-0.023192817,-0.111630455,0.020803908,-0.087236226,0.09107793,0.0010584143,-0.031080626,0.058378614,0.03154118,-0.075907834,0.032177914,-0.0027424262,0.04237425,-0.056966618,0.03753707,-0.049037453,-0.056697227,-0.026962213,-0.040559582,0.060932115,0.0137615055,-0.03155806,-0.004112746,-0.12158204,-0.05883767,-0.02466401,0.030190038,0.058419365,-0.025852172,-0.03426562,0.013337368,0.0032814995,0.051522203,0.08912356,0.031127563,0.05300115,-0.027219659,-0.10570194,0.07845488,-0.08216516,-0.0038369817,-0.074937984,-0.072774015,-0.08211753,-0.046176326,-0.005073791,0.049589146,0.00740004,-0.009112447,-0.06523674,0.04280584,-0.04539245,0.035460155,0.012751981,0.008045643,0.04051022,-0.039541148,-0.046338018,0.023548292,0.029593755,0.034504868,0.030824808,0.030563135,-0.049987987,-0.020990554,-0.0031381545,-0.020070083,0.008850866,0.01547789,0.019340305,0.06808297,-0.025437087,-0.03792825,0.07816978,-0.0077163223,-0.057823103,-0.05168879,0.010782356,-0.020948425,0.109449804,0.00676686,-0.04223603,0.043988407,-0.03388497,0.05590061,0.050568875,-0.05212367,0.08735033,0.017258363,-0.106537156,-0.023995204,-0.003753552,0.05772373,-0.026101267,0.08649562,0.084952444,-0.05244525,0.08501884,-0.0788647,-1.8491709e-34,0.043418504,0.022014864,0.013485542,-0.03478461,-0.025515186,0.023202812,-0.10436338,0.0074128876,-0.035637356,1.7046168e-05,-0.085883334,-0.016831888,0.047541194,0.067370035,-0.021595797,0.006405199,0.007256254,-0.041706737,0.040290434,0.018931523,-0.01737009,-0.009816757,-0.0387818,-0.034285508,0.051432837,0.05745747,0.012682443,0.04456824,0.05100962,0.009209754,-0.045032777,-0.101831675,-0.055754036,0.058162477,0.020297576,0.040750377,-0.0566215,-0.006843793,-0.012865468,-0.0042819977,0.048941668,-0.017633008,0.016762141,-0.044778693,0.00064308784,-0.014024992,-0.057132997,0.077794835,0.0980734,0.047455538,0.04801266,-0.057412457,0.054067366,0.006150686,0.0016529319,0.071745925,-0.07981624,-0.01676919,0.013840562,0.06807856,0.009078528,0.062022995,-0.04183738,0.055791337,0.025991272,0.03503709,-0.009681562,-0.044744547,-0.08959638,0.00074801105,-0.109063,-0.060679715,0.12661673,-0.016819544,0.013168829,-0.010378635,-0.037748918,0.0056606876,0.019889558,-0.009877177,-0.018402336,0.015462584,-0.0059560793,-0.028909793,-0.054342896,-0.0014086661,-0.037340105,-0.042513303,-0.021139944,0.060482573,-0.036876407,-0.04087952,-0.016667502,0.08784702,0.031919062,-2.105746e-33,0.058506,-0.069529995,0.04228402,-0.08032113,-0.030847616,0.0463714,0.08035356,-0.038331926,0.05122497,-0.045803502,0.026338797,0.0045187967,-0.03163339,-0.09810529,0.035885338,-0.024203906,0.042296328,0.05977007,-0.060756862,0.0134657,0.032898918,0.095855325,-0.022285154,0.025810929,0.07369332,-0.03746134,0.09061745,0.09104006,0.020683894,0.008199603,0.022831326,-0.003942061,-0.0026304834,-0.016989933,-0.0903812,0.03340078,-0.066024736,0.021738866,-0.021391505,0.0022388138,-0.010138955,0.06173452,-0.011327913,0.033835504,0.073527984,0.108136676,-0.03055083,0.0011265514,0.01161549,-0.039970342,0.00050441665,-0.041230366,0.0073296493,0.047518063,0.0057087955,0.09356236,0.015380587,0.06282437,0.039069474,-0.022025287,-0.028747067,-0.034837328,0.09419226,-0.0725933,0.038424503,-0.05960947,-0.044151742,0.037437547,-0.00071091985,0.012793034,0.06349723,-0.02279899,-0.064377,0.06447951,-0.018479569,-0.036290977,-0.105579175,-0.09390686,0.0074057006,-0.043407876,0.06390578,0.05868096,-0.034189954,-0.04153637,0.031601112,-0.0478789,0.02805418,0.13042781,0.024259357,0.030750124,-0.10435666,-0.029094297,-0.030121863,0.0044944244,0.077587366,-3.4897553e-08,0.007178372,-0.044654906,0.04106934,-0.032473505,0.023423102,0.051649183,0.03087115,0.049719796,0.0018402751,-0.07606114,-0.066061355,0.12749088,0.06028299,0.042045478,0.0016063306,0.0009795572,-0.0072600152,0.05323802,-0.026800776,0.011335,-0.055048235,-0.044516187,-0.09609065,-0.018344825,-0.030547759,-0.12209805,0.060708422,0.09612725,-0.014528639,-0.011912009,-0.008652366,0.053996753,0.0039316397,-0.02312061,-0.06790594,0.040490024,-0.07709289,-0.027137676,0.033602025,-0.0060225236,0.01146815,-0.055483345,0.0037870032,-0.015978849,-0.08214674,-0.006427454,-0.030793542,0.036834657,-0.017170329,0.0787661,0.061056364,-0.05354205,-0.09274913,-0.08131088,-0.030434709,-0.038254276,-0.003858981,-0.06878041,0.031207252,-0.03130513,0.0803515,-0.025882443,0.16969141,-0.054780547 +5.1.3.4,Requires a divalent cation for activity.,384,1.0,0.10792417,-0.080893636,0.06434881,0.058418658,-0.04045557,-0.01651594,0.09966948,0.039555,-0.0342151,0.048748065,0.02440141,-0.029305816,-0.025291389,0.14701548,0.011906313,-0.034166235,0.04633744,-0.0033538265,-0.015009375,0.12254483,0.06956427,0.08070934,0.041257966,0.03106298,-0.113237485,0.035359386,-0.051163975,-0.052490048,0.021089356,-0.03206121,0.019624656,0.06482168,0.028507732,-0.030818049,-0.009183394,0.058373645,-0.012296858,-0.0042637773,-0.017625038,0.014676147,0.014439056,-0.11578904,0.0057647843,0.006111322,-0.014216574,-0.037361346,0.02165252,-0.12494568,0.0507941,-0.036349934,-0.01675739,-0.05926738,0.013273919,0.08602916,-0.029553154,-0.02271805,-0.031176776,-0.011408319,-0.051436152,-0.014539624,-0.0060870065,0.016584689,-0.0010604112,0.030910937,0.09373302,-0.044720322,0.014193578,0.0067497604,0.023763906,0.056941006,0.049451217,-0.061745495,-0.007930879,-0.020431468,-0.0037219354,0.002850797,0.02629248,-0.07632688,0.09053005,0.02632905,-0.059115183,0.034128547,0.035094332,0.10941128,0.060507864,0.051410206,0.037492488,-0.06633319,-0.037891503,0.0611745,0.004463599,0.033645947,-0.0020432307,-0.03892787,-0.06372028,-0.044317268,-0.040383883,-0.048980843,-0.060526036,0.03477677,-0.04507861,0.05529055,-0.07412942,0.072410874,-0.012949186,-0.037653834,-0.016508305,-0.033508576,-0.008045931,0.05696742,0.006338861,-0.04356495,0.038233973,0.03869284,-0.045218248,0.09395173,0.014645932,-0.05776722,-0.0038473622,-0.01915019,0.015453148,-0.05766427,-0.011720522,0.012072306,-0.036279388,-0.04732,0.016752884,-3.4468007e-33,0.04472454,-0.04280034,0.03300334,0.02244978,-0.006348175,0.002589197,-0.094829656,-0.047450803,0.053030513,-0.060977004,-0.08982534,-0.0068917223,0.0005525585,0.0619076,0.028900826,-0.03511627,-0.03368863,0.03017396,0.07621113,-0.039231144,0.024681192,-0.026571631,0.016003836,0.021192964,0.011106036,0.011035202,0.027759193,-0.045986824,-0.004784532,0.008417544,0.049175642,-0.071199596,-0.009579326,0.04000137,-0.023639815,0.07419887,-0.056144662,-0.0053455783,-0.010100759,-0.027097732,0.022619182,0.047074318,0.005288876,0.020005953,0.08981603,-0.005207183,0.032861326,0.055324584,-0.068516955,0.016116112,0.13122682,0.058811143,0.08590021,-0.08752934,-0.04564332,0.03383555,0.040754505,-0.07821692,0.019262347,0.08017473,-0.007697899,0.032779545,0.0040329886,0.07447082,0.008096714,0.01842719,-0.05936209,-0.008163308,-5.868426e-05,-0.026707768,-0.08494028,-0.014120729,0.050507646,-0.027158346,-0.011356776,0.0060507194,-0.03740785,-0.06363197,-0.035898935,-0.037035838,-0.013783504,-0.13677636,0.010930091,0.049618624,-0.058283288,-0.0046364353,0.032819424,-0.02638929,-0.04047458,0.04390154,0.025152909,-0.028058141,-0.065734014,-0.031723723,0.021339664,1.4575136e-33,0.016059795,-0.100499436,-0.04480114,0.03788242,0.045813873,0.061865885,-0.026803926,-0.08034324,0.030971363,0.010156706,-0.039971333,0.034443613,-0.028800927,-0.011196624,0.030768229,0.026094131,-0.066036746,0.069026664,0.0062180003,0.019962221,-0.044872317,0.1062135,-0.046612088,0.075289115,0.01702083,0.07816347,-0.030196408,-0.031302456,-0.010927434,-0.035604984,0.041298237,-0.056567136,-0.081981234,-0.10034215,-0.036611084,0.0845084,-0.011735641,-0.014221389,-0.08968128,-0.058968622,-0.008270587,0.045665998,0.029758997,0.1402456,-0.02413764,0.0092302,0.009394665,-0.039650947,-0.039811786,0.050147768,0.045230713,-0.05262918,-0.039640296,-0.037922177,0.055654198,0.045150466,0.018664027,-0.09117759,-0.000198282,-0.02874768,0.06656026,0.028793102,-0.069077104,-0.04186373,0.014048671,-0.0185394,-0.027867286,0.029928243,0.04089218,-0.008975338,0.065038994,0.09245803,0.030813545,-0.06758921,-0.05268976,0.04696768,0.001979678,-0.07172091,0.027401673,-0.06889884,-0.08028505,-0.013795237,0.005116425,-0.10033922,0.043217856,-0.087434195,0.014557147,-0.020590594,-0.041111987,0.06921633,-0.0064362087,-0.041673355,-0.013281968,0.020209704,0.06704101,-2.1516694e-08,0.04737381,0.017193977,-0.021872185,-0.004516057,0.0060650227,-0.021097612,0.08900673,0.0011977577,0.05811433,0.036001667,0.042257812,0.040688492,0.10493141,0.08064159,0.09563237,-0.016717602,-0.0063833785,-0.009608963,-0.18452592,-0.028051041,-0.12305457,-0.05083972,-0.11201159,0.01664459,0.0047221426,-0.066819035,-0.011830282,0.059172526,-0.01589389,0.018338673,0.10294089,0.019224595,-0.021403844,-0.010432924,-0.047372594,0.04029159,0.083373144,-0.047874324,-0.01454621,-0.026493208,-0.08833049,-0.026031794,0.008596825,0.05489941,-0.07483448,-0.016434116,-0.08317299,0.0009889072,0.01962219,0.059973422,0.086868934,0.0028656353,0.0016329639,0.010857954,-0.047126777,0.08207781,0.04052083,-0.023933433,-0.008149114,-0.03176969,0.03928155,0.0060803685,0.09064953,-0.04969751 +5.1.3.8,Requires catalytic amounts of ATP.,384,1.0,-0.030667806,0.007906775,0.0014411388,0.00028798945,-0.009199284,-0.058057617,-0.013616591,-0.00041999193,0.04637978,0.03655293,-0.011831346,-0.035623558,-0.08404525,0.04474757,0.013206342,-0.0393046,-0.015283668,0.04287524,0.03529619,-0.054511033,0.09095864,-0.0011671224,0.017310767,-0.022292357,-0.02598687,0.039801136,0.016481057,-0.016157325,-0.028942902,0.015633887,-0.06864744,-0.027443454,-0.027749563,-0.06996534,0.026361616,0.09676248,-0.108115375,0.040297087,0.027997905,-0.008132136,0.043058496,-0.07639438,-0.010045155,0.035496216,-0.08099319,-0.061312746,0.03902882,0.010429734,0.031694967,-0.0640676,-0.056572307,0.012339856,-0.04767503,-0.07963674,0.02957588,0.00745913,-0.04763939,0.02130379,-0.0012797355,-0.03943848,-0.0096414415,-0.023815203,-0.047674645,0.036362678,0.09858101,-0.059706967,-0.009209769,0.021979162,0.030999914,0.06737283,0.0038827055,-0.04892214,-0.043328658,0.027932703,-0.012817475,-0.006549741,0.012130471,-0.05833903,0.08531048,0.013098437,0.016004499,0.03291436,0.021652672,0.060770668,0.08056887,0.012758624,0.032212056,0.0027822596,-0.039210875,0.026241379,0.030304033,-0.008124534,0.013262381,-0.0025352747,-0.01295147,0.012668819,0.07633342,0.014171241,-0.05307876,0.012639781,0.022968043,0.11623665,-0.005697118,-0.011834829,-0.041558236,0.043636072,-0.008544779,0.056488965,0.03224083,0.05710135,0.027423467,-0.028162533,0.04814467,0.0018815863,-0.030906187,0.08136801,-0.00023943365,-0.065401934,-0.052316375,0.052186828,-0.06568845,-0.07328226,-0.03852753,0.029727375,-0.060270872,0.009766731,-0.021497682,-3.3902142e-33,-0.019621508,0.00379432,0.039400857,0.022273546,-0.045203652,-0.0023930492,-0.08948456,-0.034703303,-0.020586524,-0.07035092,-0.019489616,-0.0677841,0.0081456695,0.011148555,-0.0379914,-0.070944875,-0.022576803,0.06950618,0.08907076,-0.050742496,-0.018704161,-0.043879118,0.0049068728,-0.040124692,-0.009034227,0.03980055,-0.013012665,-0.041665804,0.035904318,-0.0030029372,0.00922953,-0.06203181,-0.054602604,0.00488013,-0.013097525,0.003928637,-0.07731386,-0.045169562,0.04087315,0.0055504898,-0.042676512,0.061163124,-0.007920969,-0.016268149,0.047605406,-0.033980303,-0.018198147,0.10045122,-0.04303417,0.08256499,0.09050536,-0.03915699,0.07136984,-0.0140434,-0.016644944,-0.017753234,0.02763477,-0.04112323,0.018202169,0.08000112,0.01843633,0.073910594,-0.034336355,0.09619313,0.02841629,0.06643948,-0.09177898,-0.00996139,0.003614513,0.12567392,-0.09535124,-0.032046463,0.059509452,-0.04219545,-0.00879397,0.017675797,0.024990281,-0.0038063745,-0.048861768,0.062001705,0.030811599,-0.07691717,0.012852666,0.02342219,-0.019888502,-0.034057204,-0.053950917,-0.032776408,0.005995603,0.041871328,0.09998132,-0.087038904,-0.09356768,0.04708576,-0.007412579,1.0495189e-33,0.09552687,-0.0683276,0.080544084,-0.13456592,-0.03881619,0.0232561,0.0012230241,-0.17962465,-0.005764969,-0.0033465128,0.012367825,-0.03477938,-0.028705588,-0.021302262,0.018530335,-0.012734157,-0.02104529,0.06318868,0.022325605,0.00030444458,0.011853896,0.15176816,-0.008393509,0.08450798,0.0110288365,0.008879787,-0.0413937,0.037318066,0.055329006,0.01955218,0.011345123,-0.048351657,-0.08322517,-0.007680258,-0.011350163,0.042968575,0.0120580895,0.064210445,-0.016397834,0.026293814,0.03637917,0.075776376,0.031370625,0.09444602,0.02977195,0.03617529,0.032136764,-0.017809156,-0.03311568,-0.056243084,0.077990234,0.010690922,-0.062469296,-0.0050274166,0.026499765,0.05306061,0.04572523,0.000104900326,0.021451697,-0.04464376,-0.03195051,-0.056050945,0.030730823,-0.06557208,-0.024703499,0.0042673727,-0.053968858,0.017402714,-0.022541016,0.055434525,0.07983646,0.07401386,0.009012051,-0.02496227,0.030846765,0.10907518,-0.022565076,-0.018058946,-0.005313104,-0.023051163,-0.113846116,0.09401713,-0.0486301,-0.07230638,0.04934328,-0.08644831,0.022973403,-0.022567695,-0.014112287,0.03338405,0.037022416,-0.06690435,0.05079865,0.050754998,0.021828905,-1.4979573e-08,-0.00824525,-0.017126264,0.09571378,-0.049345374,0.0054092067,0.10188588,0.07678321,-0.0028999662,0.09647463,-0.027205933,0.025303593,0.057709556,0.056986637,0.06301808,0.08601887,0.030376446,-0.09936986,-0.011390696,-0.056390833,-0.100082904,-0.09465909,-0.05993175,-0.12520532,0.11453018,0.035693534,-0.09327122,0.03317699,0.056053564,-0.0357591,-0.046189107,0.049757183,-0.019028107,-0.01016347,0.003594528,-0.011079722,-0.011810375,0.006146285,-0.007994102,-0.054186705,-0.08520022,-0.097436234,-0.003496728,-0.055202994,0.017392056,-0.004511316,0.056345154,-0.0799919,0.066266954,-0.03400864,0.02481225,0.045505222,-0.04922765,0.009381935,-0.057312954,-0.03436276,0.009686025,-0.017938271,-0.017754205,0.0010543091,-0.052602556,0.116510026,0.03291334,0.1687583,-0.060114756 +5.1.3.9,The enzyme found in bacteria accepts N-acetyl and N-glycoloyl derivatives [1].,384,1.0,-0.07314846,-0.07266956,-0.104855314,-0.002768301,-0.01619387,0.020397918,-0.097394556,0.024368878,0.037188035,-0.040757496,0.07467442,0.022492358,-0.09116879,0.04065044,-0.0914593,-0.0030294273,-0.013369823,0.015331256,0.008487101,-0.017702809,0.009828233,0.04510335,-0.045742575,-0.048469108,0.03802607,0.030748073,0.032673363,-0.0032052614,-0.007812951,-0.109815106,0.004874311,-0.03346186,0.087672636,-0.06897854,0.07952673,0.033413447,-0.010742702,-0.0312887,0.1099021,0.004526269,0.018556478,-0.0119447615,-0.013882601,-0.005435411,-0.0027400658,-0.04279917,0.0050378125,0.004209153,0.07819309,0.03400407,-0.062291496,-0.013736455,-0.04314297,0.00070530945,0.04225269,-0.0048643975,-0.11037358,-0.05130274,0.026995428,0.013874145,0.06232318,-0.004782912,0.043415997,-0.023465784,-0.043960888,-0.05138935,0.06711487,-0.1054209,-0.004562264,0.05010201,-0.06547324,-0.053436875,-0.0015900983,0.026620034,-0.026402975,0.048710782,0.00012533068,-0.031598184,0.07808384,-0.02535375,-0.01926496,-0.010682906,0.04999828,0.08220937,0.002705735,0.00576958,0.009503947,0.03936332,0.09140669,0.004168931,-0.0004216017,-0.074991144,0.02659811,-0.11072412,-0.032051314,-0.008280886,0.002467112,0.03650257,-0.024266267,-0.019914236,-0.023681266,0.04028244,-0.0036631161,-0.059640985,-0.05744333,0.07063297,0.05688613,0.065082826,0.08738751,0.0047437903,-0.09234787,0.035774957,0.025622893,-0.03281917,-0.09614978,-0.0023440712,-0.040165246,-0.082419366,-0.040501393,-0.0022085335,0.027221112,-0.059658125,0.04050934,0.045417488,-0.03310956,0.123382494,-0.019638963,-1.6828967e-33,0.065185755,0.057796117,0.02588913,-0.027217073,0.07713847,-0.08830226,-0.059788693,-0.023640271,-0.015826376,-0.06093936,-0.014612192,-0.056064248,0.002060039,0.034367543,-0.0028817034,0.0906425,-0.01573662,-0.01792115,0.061904393,0.027485082,0.040781505,0.020641668,-0.010148252,0.031992525,0.018593011,-0.01030793,0.03540586,0.076603495,0.09990284,-0.0048376587,0.031253695,-0.10471643,-0.060354516,0.001022513,0.07998327,0.02206381,-0.0056924825,-0.04200389,0.05078798,0.04473756,0.009607619,0.06971548,0.015109516,0.036669884,0.017974548,0.02597977,-0.038219888,0.060477328,0.007770399,0.062643304,0.016607353,-0.03232578,0.050794255,0.012734782,-0.0009886777,0.07232456,-0.08401586,0.072035134,0.013756057,0.027566874,-0.018491875,0.022054972,0.023430372,-0.052074123,-0.012236504,0.05985271,-0.024432525,-0.015454875,0.043948255,0.03691005,-0.031645015,0.011910548,0.03660404,0.11221231,0.008166825,-0.08215955,-0.034051582,0.0022941618,0.0969241,-0.045269795,-0.021632658,0.0019935283,-0.019960742,-0.034902092,-0.07511401,-0.022221932,-0.038840305,-0.054033544,-0.017421916,-0.0021179547,0.05663465,-0.06438284,-0.03357987,0.04504977,-0.043266624,-5.437835e-34,0.08685717,-0.11673188,0.058659963,-0.02586475,-0.1453175,0.073780976,-0.028530443,-0.07678483,0.035409376,0.010090827,0.0850788,0.047285564,0.0063229757,-0.037183836,0.0073886113,-0.004624936,0.012607194,0.04050044,-0.04316234,-0.05117258,-0.000882467,0.036489002,-0.024010897,0.0015321638,0.05120385,0.043216478,-0.06214213,0.053354777,0.009567451,0.05257141,-0.008891458,0.030252421,-0.03783632,-0.05922649,0.012582957,0.071403764,0.0077505596,0.024305845,-0.068335414,-0.040516812,-0.00084901246,0.054574747,0.052429806,0.09243272,0.03943066,0.06674852,-0.07282147,0.00022717814,-0.0064853267,-0.039793346,-0.0005602593,0.0048322193,-0.061351538,0.02679954,0.010130685,0.123939276,0.058189828,0.04456811,-0.03516037,-0.04158855,-0.07055512,-0.08048711,0.05795708,-0.013435584,0.024189778,0.087238826,-0.055718523,0.08043096,0.05044613,-0.047616083,-0.03514099,-0.01120022,0.065562814,0.08637248,0.0046926183,-0.0018557858,-0.03262801,-0.11900855,-0.024990262,-0.030351037,0.0020474803,-0.007333581,-0.053082198,-0.03556401,-0.07731224,-0.0470085,0.104838945,0.08828047,-0.005885292,0.045696042,-0.017729461,-0.04356839,-0.049162935,0.0072756675,0.04366759,-2.8223356e-08,0.037603885,-0.044005282,0.05109737,-0.095260866,0.03841825,0.06173026,-0.07244261,-0.029883232,0.063115604,-0.019817352,-0.07968246,0.118771076,-0.021099681,0.003090816,-0.04432257,0.054195244,-0.062274832,-0.013526244,-0.033992987,0.020958077,-0.12963545,0.06695288,-0.08182312,0.0262108,0.050201185,-0.059103407,0.025140502,0.021907555,-0.060515895,-0.00012860182,-0.019020159,0.043797173,0.0040520057,-0.041420538,-0.04599067,-0.0069058584,0.008265935,-0.036289945,-0.0060846354,0.05696411,0.032801062,-0.02307913,-0.04991152,-0.01429287,0.010900406,0.032715824,0.0059016407,0.010627264,-0.090206355,0.006610331,0.036469832,-0.037994795,-0.03252093,-0.085568324,-0.114754744,-0.0011817291,-0.044506002,-0.0715967,0.022785064,-0.008638087,-0.043028373,-0.01410354,0.1765225,0.0162084 +5.1.3.10,Requires NAD+. ,384,0.99999994,-0.068784244,0.022418734,-0.05395276,-0.016134605,-0.048972655,0.06289607,-0.030143913,0.010669374,-0.0031832755,0.03938312,-0.022099515,-0.014993883,-0.05836922,0.08770228,0.0050570834,0.018540734,-0.0042414665,0.026848052,0.021070827,0.025145218,0.05106827,0.0034229825,0.07272325,-0.01820857,0.06801249,-0.013825333,-0.04955796,0.027358191,0.08908756,-0.050625954,-0.026951816,0.04205754,0.0037146886,-0.04177399,-0.0748769,0.008751,-0.0671107,-0.0015588955,-0.026578397,0.03399766,0.006918131,-0.06070343,-0.030888788,0.08663879,-0.018772207,-0.08274649,0.01604079,0.043075323,0.052878786,0.013214727,-0.080028646,0.011352265,-0.028130516,0.01312926,0.05106472,-0.040237524,0.0043855277,-0.02019801,-0.019096877,-0.03184778,-0.03829078,-0.07046345,-0.08907334,0.049261887,0.084527776,-0.0030918042,0.033161093,-0.0016798151,-0.041360065,0.04743682,-0.08996855,0.03448869,0.008086289,0.04895464,0.0033891154,0.07331993,-0.0834842,-0.059768096,0.12877712,0.019068487,-0.036896426,0.022171225,-0.09052174,0.006939413,0.148,0.054675564,-0.0262088,-0.025799695,-0.048744675,-0.0059924666,0.002659479,-0.019939646,-0.009184738,0.060988147,-0.07809205,0.005795684,0.02040639,-0.013456044,-0.054213747,0.062357493,-0.018138539,0.081477076,-0.042604357,0.017021624,-0.057537436,-0.021139836,0.02836714,0.075321995,-0.060083445,0.022795675,0.0018487718,0.008646827,0.036985636,-0.05903662,-0.069200076,0.09812881,-0.020373078,-0.0065029617,-0.022361925,-0.056976266,-0.033164438,-0.007400372,-0.01664545,0.003757073,0.008133842,-0.050095886,-0.005648727,-4.6826655e-33,0.09235815,0.053381607,0.011236215,0.101158425,0.00537776,0.06096435,-0.07489848,-0.0071163117,-0.060803853,-0.0700502,-0.06295463,-0.07782668,0.01204183,-0.018896898,0.1015891,0.05218985,0.019164145,-0.050406057,-0.034262955,-0.047203243,0.043098826,0.024661131,-0.022693992,0.02800246,-0.0012545397,0.05890502,0.034546785,0.0029720182,-0.019439047,0.027478356,0.048554108,-0.091883585,-0.10473349,0.013965205,0.030152163,0.05400297,-0.07275051,-0.042714007,0.036397982,0.04479246,-0.07412692,0.07226453,-0.023663497,-0.037748724,0.03710915,-0.07952673,0.074475825,0.10534079,-0.010932429,0.075410545,0.012110483,-0.0028663073,0.05779702,-0.016673623,-0.016755205,0.07592219,0.047118023,0.023571527,-0.00023791703,0.13184597,0.02570253,-0.010675352,0.008317981,0.0952034,-0.1333189,0.011129947,-0.10632704,-0.063091494,0.04861219,0.025806163,-0.00073955284,0.014275241,0.022426158,0.008276234,0.03008718,-0.039278056,0.04939535,-0.048849594,0.039260104,-0.013528978,-0.04777145,-0.035876114,-0.036817443,-0.003507305,-0.009655525,0.008721995,0.029109854,-0.03092304,0.0042825704,0.050488494,0.015952077,-0.050346483,0.003917202,-0.075381815,0.005995462,3.5683013e-33,0.008666229,0.023690471,0.033188492,-0.038307637,0.05668417,0.037942223,0.044404674,-0.15212792,-0.02121102,-0.033166315,0.027741743,0.066393435,0.016479477,-0.027978702,0.041975334,0.011642443,-0.047278635,-0.042929888,-0.01666137,0.005573764,0.03108645,0.14377129,0.05788203,-0.013367904,0.016548466,-0.007328594,-0.059595197,0.07251483,-0.034135554,0.020862678,0.028216284,-0.030110588,-0.14643659,-0.03386408,-0.026493067,-0.0015618615,0.03777906,0.032975253,-0.07400526,0.07372354,0.048474804,-0.0144634,-0.065260656,0.121435314,0.0373355,0.013210664,0.009054245,-0.06332412,0.059819728,-0.0062959595,0.014621496,0.030492662,-0.07029178,0.01342423,0.038662367,-0.030760875,-0.05184861,0.0384025,0.044074986,0.018195717,0.010647544,-0.004967413,-0.007159373,-0.08326248,0.08556603,-0.01600033,-0.012172479,0.03631843,0.06073559,-0.009464251,0.01077439,0.07198811,0.027298933,-0.043068696,-0.024945712,0.014567159,-0.09518998,0.06947885,-0.00300315,-0.045961615,-0.10132435,-0.044271108,-0.034111995,-0.04923552,0.062957555,-0.0379409,0.09729444,-0.08145696,-0.039517954,0.033203647,0.010323052,0.065752506,0.03948528,0.05980218,-0.039136354,-1.36368214e-08,0.011917475,1.4051582e-05,-0.008929142,-0.041335717,0.015977448,0.04482951,0.04343147,-0.05939641,0.005649391,0.0841547,0.10219494,0.06787922,0.10947131,0.08929926,0.05504755,-0.042749096,-0.027997276,0.044140257,-0.13267455,-0.059283596,-0.08438194,-0.009634608,-0.062240873,0.13391988,0.020837365,-0.025069237,0.04183363,0.008890681,0.07415761,0.014711166,0.0459055,0.02139782,0.031297736,-0.031419113,-0.05101551,0.08786982,0.015182211,0.055078566,-0.0017691798,0.030714078,-0.060774807,-0.02285261,-0.034646068,0.04620305,0.007813163,-0.006140888,-0.030427573,-0.058426578,-0.05958858,-0.056472886,0.051814105,-0.0064982097,0.020516662,-0.029650418,0.0017921556,0.04033117,-0.00051783497,-0.0089936,-0.0075611235,-0.049609393,0.09806807,-0.030335858,0.064939946,-0.047290713 +5.1.3.11,"The enzyme catalyses the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety.",384,1.0,-0.003013912,0.0072535765,-0.0014761286,0.00065418746,0.013428145,0.042793807,0.0045000957,-0.028394062,0.030242909,0.0907909,-0.009605012,-0.0010985937,-0.042837303,-0.015726909,-0.059842736,-0.027928254,-0.028346503,0.036526337,-0.02214163,0.007241329,0.07336256,-0.0760896,0.035312317,0.014399895,0.09386445,-0.023230374,0.04710188,-0.04231844,-0.0052987747,-0.096254736,-0.0009924439,-0.08493592,-0.008862926,0.0036379632,0.007598813,0.0758543,0.09560133,0.0012585451,0.03507748,-0.06806408,0.043423403,0.019851828,0.017066916,0.035668377,-0.03301035,-0.014046366,-0.07698533,0.14405762,0.02374656,-0.03267114,-0.033508256,-0.04219842,-0.042342838,0.00820735,0.041571062,0.06108904,-0.0026317076,0.043716487,0.004789227,0.043709494,0.040608097,0.034356277,-0.017671075,-0.010479897,-0.010342313,-0.124891184,0.033646494,-0.059376925,-0.023168322,0.027136995,-0.083885305,-0.033021923,-0.016990846,-0.041558664,0.0748231,-0.01388011,-0.052084424,-0.0465555,0.024535356,0.0058368943,0.04960085,0.03377623,0.09929605,0.03809474,-0.0180655,-0.053599034,0.027136846,-0.04325775,0.10152216,-0.05649337,-0.011144405,0.012700762,-0.0271759,0.05647989,-0.03232368,-0.015908888,0.054375023,0.02797175,0.086242795,0.004178215,0.03873565,0.005643178,-0.0017847149,-0.10788329,-0.043758135,0.052673753,-0.0014718157,0.08654238,0.0019983826,-0.008122868,0.02759601,0.04995652,0.014126368,0.09400292,-0.16154255,0.04811899,0.010003078,-0.10808609,0.037647624,-0.06221801,-0.010895155,0.007685753,0.062182415,0.009275356,-0.079921134,0.03589205,-0.023074374,-3.4951724e-34,0.023482002,-0.030867927,0.024304627,0.004012244,0.056582674,0.005959347,-0.10264956,-0.020088265,-0.057877358,0.047219697,-0.106513396,-0.061139025,-0.008668244,0.07295234,-0.044921942,-0.007132611,0.026616689,-0.012745495,0.03452089,0.0055713328,-0.05862001,0.066030055,-0.037704818,-0.0076929107,0.08360058,0.08399694,-0.052260295,0.072068065,0.11759665,0.023183841,0.038517676,-0.036035996,-0.0426848,-0.016327884,0.037423477,0.05180902,-0.055133637,0.03750316,0.032857627,0.022521485,0.031797864,8.806263e-05,-0.004199547,-0.111390494,-0.010962074,-0.019422565,0.089356355,0.031874906,-0.03710587,0.075400636,0.04664046,-0.02859321,0.025039293,0.025475424,-0.058376826,0.07262959,-0.022359468,-0.058748465,0.031369593,0.042896274,-0.045796707,0.03339291,-0.010954768,-0.024983099,0.038468953,-0.025344789,-0.027476754,0.017491799,-0.038657237,0.0031981918,-0.11518752,-0.047209397,0.08640017,-0.03321762,0.018125704,-0.045065746,-0.06919113,0.007471341,0.05875029,-0.04283143,0.045910213,0.050900884,-0.02317233,-0.07361669,-0.04484515,0.00075156667,-0.07440866,-0.050423473,-0.034414243,0.02737228,-0.03885348,0.0060998513,-0.051436003,0.039026514,0.045420405,-3.310123e-33,0.08882882,-0.10349189,0.086703055,-0.05011708,-0.05448036,-0.027070768,0.0902946,-0.13657762,0.038665492,0.005352958,0.06312328,-0.006179667,-0.059776716,-0.0064048013,-0.015358569,0.04804767,-0.08063616,0.054101847,-0.06338155,0.004531967,0.007983525,0.04973774,0.03004788,-0.013804069,0.03687409,-0.04566032,0.051684905,0.06964828,0.08526609,0.04018379,0.006844474,-0.063950375,0.007055007,-0.03282527,-0.051610146,0.007904307,-0.124726035,0.0033005916,-0.0040534674,0.024675976,-0.007334008,0.033035204,-0.02255813,-0.06175021,0.10561888,0.060742967,-0.070881054,0.04378692,-0.06996163,-0.031769153,-0.006022285,-0.038840037,0.008275216,0.024735231,-0.0087927,0.049331386,-0.0038694192,0.051738255,-0.01008023,-0.038581625,-0.018550938,-0.06276425,0.07798779,-0.009449685,0.07253532,-0.0035049345,-0.048614264,0.033609413,0.05213562,0.025091553,0.010414016,-0.0040358035,-0.047770392,-0.008989106,-0.009936228,-0.035817094,-0.13528682,-0.058955997,-0.008927951,-0.017760849,-0.022451192,0.052050572,-0.033469003,-0.0885763,0.0018594991,-0.03987613,-0.0018668812,0.11244137,0.0053606955,0.09591873,0.0005045051,0.009062153,0.03204844,0.07448498,0.08898204,-3.142555e-08,0.05305961,-0.013544006,0.0145991305,-0.018011367,-0.06438219,-0.003762231,-0.028270852,0.025096197,0.022899704,-0.025327142,-0.023751581,0.08649496,-0.0026307856,0.020283112,-0.0209129,0.0090214675,-0.056438383,-0.023827361,-0.028080314,0.05057919,-0.07659075,0.015349118,-0.06670762,0.044697244,-0.0017716752,-0.0758729,0.03624585,0.0009639855,-0.110954344,-0.002985156,0.052163135,0.098953456,-0.016540978,-0.07900817,-0.036358792,0.025374046,-0.057285458,0.017755833,0.045217406,-0.011676625,0.07697976,-0.044993337,0.00057490746,-0.0077093346,-0.018732043,0.05201996,-0.0041467356,0.058597043,-0.02732854,0.09595372,-0.006632561,0.033363346,-0.13060258,-0.08827823,-0.062337447,-0.0034594394,-0.09022761,0.030972542,-0.012325623,-0.084964424,0.029058842,-0.023968777,0.06479769,-0.08927771 +5.1.3.12,Requires NAD+.,384,1.0,-0.06878425,0.022418711,-0.053952727,-0.016134635,-0.04897264,0.06289609,-0.030143915,0.010669343,-0.003183227,0.03938317,-0.02209948,-0.014993911,-0.058369208,0.08770232,0.005057102,0.018540792,-0.004241495,0.026848016,0.021070817,0.025145229,0.051068284,0.003422877,0.072723284,-0.01820859,0.06801252,-0.013825288,-0.049557935,0.027358204,0.089087516,-0.050625946,-0.026951827,0.042057585,0.003714755,-0.041774,-0.07487685,0.008750964,-0.06711072,-0.0015589169,-0.026578454,0.033997674,0.0069180927,-0.060703434,-0.03088875,0.0866388,-0.01877226,-0.082746536,0.016040761,0.043075323,0.05287882,0.013214744,-0.08002864,0.011352289,-0.028130516,0.013129261,0.051064674,-0.040237524,0.0043854923,-0.020197976,-0.019096883,-0.031847764,-0.038290802,-0.07046345,-0.08907335,0.0492619,0.0845278,-0.0030918056,0.033161044,-0.0016798137,-0.041360088,0.04743689,-0.08996856,0.03448865,0.008086315,0.04895464,0.0033891012,0.07331984,-0.083484225,-0.059768118,0.12877707,0.019068506,-0.036896434,0.022171225,-0.090521745,0.0069394433,0.14800002,0.05467556,-0.026208809,-0.025799705,-0.048744645,-0.0059925215,0.0026595385,-0.019939635,-0.009184698,0.060988102,-0.07809198,0.0057957186,0.02040638,-0.013456087,-0.054213773,0.062357537,-0.018138552,0.08147702,-0.042604342,0.017021615,-0.057537433,-0.02113984,0.02836716,0.07532199,-0.060083464,0.02279571,0.0018487689,0.008646811,0.03698565,-0.059036586,-0.06920008,0.09812879,-0.020373061,-0.006502994,-0.022361793,-0.056976307,-0.03316445,-0.0074004014,-0.016645474,0.0037570226,0.0081338165,-0.050095916,-0.0056487187,-4.6826648e-33,0.09235815,0.05338163,0.011236184,0.10115843,0.0053777806,0.060964406,-0.07489847,-0.0071162726,-0.060803924,-0.07005021,-0.06295462,-0.077826686,0.012041837,-0.018896807,0.10158911,0.052189797,0.019164147,-0.050406016,-0.034262966,-0.047203273,0.04309886,0.024661193,-0.02269407,0.028002527,-0.0012545489,0.05890502,0.034546826,0.0029719756,-0.019439071,0.027478365,0.04855415,-0.091883585,-0.10473347,0.013965188,0.030152159,0.054002997,-0.072750494,-0.042713985,0.03639799,0.04479241,-0.07412687,0.07226459,-0.02366356,-0.037748724,0.037109118,-0.079526655,0.074475884,0.10534082,-0.010932426,0.07541058,0.012110492,-0.0028663273,0.05779693,-0.016673632,-0.016755233,0.075922236,0.047118027,0.023571553,-0.00023787416,0.13184592,0.025702558,-0.010675333,0.008317998,0.0952034,-0.13331889,0.011129972,-0.1063271,-0.063091435,0.04861221,0.02580615,-0.00073961064,0.0142752025,0.022426242,0.008276227,0.030087216,-0.03927804,0.0493954,-0.04884962,0.039260026,-0.013528945,-0.047771476,-0.035876106,-0.036817458,-0.003507331,-0.0096555045,0.008722018,0.0291098,-0.03092306,0.004282515,0.05048849,0.015952094,-0.050346527,0.0039171963,-0.07538181,0.0059954314,3.5683005e-33,0.00866626,0.023690503,0.03318855,-0.03830764,0.056684222,0.03794229,0.04440472,-0.15212803,-0.02121104,-0.033166327,0.027741728,0.06639345,0.016479481,-0.027978659,0.041975386,0.011642394,-0.04727861,-0.042929877,-0.016661396,0.005573803,0.031086456,0.14377128,0.057882022,-0.013367941,0.016548494,-0.0073285582,-0.059595108,0.072514884,-0.034135524,0.020862656,0.02821628,-0.030110646,-0.14643662,-0.033864122,-0.026493056,-0.0015618297,0.037779097,0.0329752,-0.07400528,0.073723495,0.048474837,-0.014463436,-0.0652607,0.121435285,0.037335522,0.013210648,0.0090542305,-0.063324176,0.059819736,-0.006296046,0.014621462,0.03049263,-0.070291854,0.013424272,0.03866232,-0.0307609,-0.05184867,0.03840256,0.044075005,0.018195717,0.010647509,-0.004967439,-0.0071593733,-0.083262466,0.08556599,-0.0160003,-0.012172486,0.03631846,0.06073557,-0.00946426,0.010774417,0.0719881,0.027298948,-0.043068673,-0.024945745,0.014567179,-0.095189996,0.06947878,-0.0030031013,-0.045961633,-0.10132435,-0.04427107,-0.034111977,-0.049235493,0.06295752,-0.037940934,0.097294465,-0.08145694,-0.03951798,0.033203676,0.0103231,0.065752484,0.03948528,0.0598022,-0.039136365,-1.3636822e-08,0.011917494,1.4096073e-05,-0.008929148,-0.041335754,0.01597744,0.044829488,0.043431498,-0.05939643,0.005649463,0.084154725,0.10219487,0.067879215,0.10947128,0.08929933,0.055047493,-0.042749062,-0.027997252,0.044140235,-0.13267457,-0.0592836,-0.08438197,-0.0096346075,-0.062240858,0.13391991,0.02083735,-0.025069138,0.04183365,0.008890681,0.07415759,0.014711216,0.04590546,0.021397868,0.031297743,-0.031419184,-0.051015496,0.0878698,0.015182229,0.055078547,-0.0017691129,0.03071403,-0.060774803,-0.022852689,-0.034646098,0.04620306,0.007813158,-0.0061408314,-0.030427601,-0.0584266,-0.059588622,-0.05647291,0.051814128,-0.0064982073,0.020516653,-0.029650392,0.0017921664,0.040331192,-0.00051787606,-0.008993585,-0.007561174,-0.049609452,0.09806808,-0.03033586,0.064939894,-0.0472908 +5.1.3.13,The enzyme occurs in a complex with EC 1.1.1.133 dTDP-4-dehydrorhamnose reductase.,384,1.0,-0.03457728,-0.037701953,-0.10022304,-0.069674075,0.0011065577,-0.020787133,-0.052930307,0.06976244,0.0093945125,-0.04981906,0.069177456,-0.08527235,-0.08706401,-0.0013232711,-0.05299396,-0.009024054,-0.05180617,-0.039716907,0.041572146,-0.038417786,0.018788047,0.012556735,-0.032896623,-0.0011971148,0.03650278,0.019680433,0.1020174,-0.0038266703,-0.014818204,-0.11994021,0.033756465,-0.06323269,0.08481916,0.033037346,0.06735786,0.09189824,-0.069350354,-0.104010224,0.0028980658,0.004538841,0.08640775,0.023157733,0.031568218,-0.07072097,-0.008805698,-0.022773134,-0.037582386,0.06836784,0.05101414,0.012908739,0.04014503,-0.018500313,0.031047191,0.064660884,0.0308616,0.048811503,-0.009097133,0.06500129,-0.08187434,0.07839169,0.11912365,-0.026790116,0.0019087481,-0.031133147,0.01990911,0.040031277,0.064552814,-0.057407957,-0.02339588,-0.046863332,-0.038400076,-0.017012758,-0.029189706,0.022989953,-0.047889296,0.031279203,-0.037119977,-0.05361742,0.055068173,-0.019348824,0.037482686,0.0506549,0.010012161,0.017665979,0.03753778,-0.01134473,0.027200397,-0.023045048,0.04313749,0.029873122,0.0064964555,-0.013354955,-0.051294304,0.040180285,-0.056781135,0.110466704,-0.0025717004,0.10411595,0.0564008,-0.06518632,-0.010976654,0.113373674,-0.08552721,-0.040149853,-0.09642194,0.0024716575,0.002802058,0.055401407,-0.003283674,-0.010321899,-0.004406485,-0.0159236,0.076599054,0.04476821,-0.0051788916,0.02993244,-0.011961847,-0.04372681,-0.0710655,-0.019338278,0.041869022,-0.03162361,0.022271222,0.04789281,0.0076098293,-0.02097006,-0.1337257,-7.3431387e-34,0.07913843,0.023641994,-0.038532957,0.00652261,0.040113427,-0.0059161237,-0.07617191,0.08125888,-0.08449,0.0020724135,-0.086152695,-0.0850625,0.0060176766,-0.0369046,-0.09153834,-0.044356417,0.026679505,0.012275075,0.020839201,0.015698547,0.03643051,0.08596898,-0.069159195,-0.0100221215,-0.02532193,0.10096043,-0.038433064,0.025532192,0.11431521,0.023544997,-0.050886787,-0.1335816,-0.09504905,0.038012516,0.028402612,-0.024686893,-0.051593143,-0.026551507,-9.796376e-05,0.035338234,-0.00085419265,0.021797372,-0.019725751,-0.024594918,0.058781885,-0.034704555,0.021059176,0.026375214,0.0658939,0.049389962,-0.00045693186,-0.042305164,0.11353807,-0.06655383,-0.000809201,-0.040451046,-0.095371,0.02877865,0.047301333,0.0840079,0.04113367,0.085895814,-0.061430782,0.048298474,0.028465938,0.012233885,-0.051316995,-0.04279127,0.00035014583,-0.0013059204,-0.029885674,-0.026372349,0.06453548,-0.014912804,0.05535714,-0.033841167,0.007978897,0.03579364,-0.04770786,0.018278016,-0.10082624,-0.005377074,0.023168629,-0.035360225,0.013947405,0.024994072,0.012169262,0.026315851,-0.009343613,0.040502377,0.047153886,-0.009841763,-0.087084286,-0.033022787,0.059507426,-7.414764e-34,0.06652913,-0.0759703,-0.011902982,-0.10726377,-0.03748865,0.085717484,0.038716942,0.042280976,0.083059296,0.026613649,0.10720489,-0.039940838,-0.048858218,-0.11266666,0.042875804,0.034896538,-0.053410884,0.059918206,-0.02515057,-0.0106283985,-0.0057934094,0.10408147,0.019479018,0.04333861,0.017395504,0.024543624,0.043201502,0.050851043,0.0062374333,0.046391975,-0.061701167,-0.009744947,-0.036494594,0.040261064,-0.07856219,0.08149103,-0.06126118,-0.054597057,0.01692869,0.018949106,0.013573016,0.0035042458,-0.00894761,0.018865224,0.05340003,0.023834703,-0.07451561,0.08995938,-0.004766733,-0.0140047,0.05985937,-0.0099344505,0.04383475,6.7707944e-05,0.013735846,-0.009301123,0.021300863,0.042091172,-0.058558475,0.022148004,-0.027758814,-0.071749315,-0.003374557,0.04489171,-0.010210774,0.014188637,-0.019908711,0.053505767,0.024527663,0.022206921,0.07189655,0.014007199,-0.06616164,0.047319192,-0.024516337,-0.06778024,-0.08811888,0.020100689,0.026966313,-0.062274788,-0.022506408,0.028224377,0.017480753,-0.0792301,0.06686573,-0.055550776,0.0357819,0.091956265,-0.052563563,0.029628469,-0.050512552,-0.0016918149,-0.07309043,0.06536164,0.021884734,-2.7068939e-08,0.07306135,-0.05510848,0.023397911,-0.09491836,0.093905225,-0.016989132,-0.027755775,0.041055918,0.023934886,-0.049822778,0.015102192,0.06546927,0.012752644,-0.017414866,0.062630095,-0.003567913,-0.050444882,-0.024376066,-0.035496045,0.033939045,0.041810945,-0.048474748,-0.14548214,0.021187184,0.012343906,-0.010811228,0.07106179,0.030554874,-0.006866199,-0.011506421,0.05105255,0.0179639,-0.031106355,-0.050058234,-0.017333867,-0.01247116,-0.03103182,0.000118298485,-0.05593208,0.003746781,-0.026128987,-0.07635021,-7.486967e-05,0.015591326,-0.07255259,0.038478978,-0.009054815,-0.0031940872,0.044252783,0.03445887,-0.033845518,0.027038736,-0.012425995,-0.059254404,-0.1252077,-0.009809152,0.035125118,-0.06992507,-0.04134767,-0.053878155,0.048710555,0.0142036285,0.13569981,-0.021258263 +5.1.3.14,"This bacterial enzyme catalyses the reversible interconversion of UDP-GlcNAc and UDP-ManNAc. The latter is used in a variety of bacterial polysaccharide biosyntheses. +cf. EC 3.2.1.183, UDP-N-acetylglucosamine 2-epimerase (hydrolysing).",384,1.0,-0.050578743,-0.04526145,-0.057633232,-0.07972808,0.0384049,0.026771579,-0.019410323,0.0116141895,-0.04436792,0.06649878,0.014747889,0.014111074,-0.036861617,0.018206231,-0.113884196,-0.00071230315,-0.03348747,-0.01269451,0.0350895,-0.03495716,0.07805366,-0.004825418,-0.027334921,-0.012558606,0.08242414,0.024286514,0.06788326,-0.021476414,-0.006338551,-0.1050079,0.025171349,-0.10247354,0.041481704,-0.046608035,0.09135666,0.15764612,0.019739099,0.025108667,0.08151502,-0.014640356,0.0057226974,-0.024781536,-0.00103866,-0.018741604,2.6274354e-05,-0.048879106,-0.057271246,0.08887264,-0.010475461,0.0014739392,0.017347867,0.015328626,-0.035375714,0.023120673,0.06308237,0.03736394,-0.027985148,-0.0059126467,0.01411403,0.015150222,0.016246233,0.027285602,-0.0061627203,-0.034102704,-0.01750061,-0.05473205,0.10186003,-0.10261399,-0.040763795,0.06577829,-0.050022427,-0.026462948,-0.06491399,0.023573857,0.039405975,-0.01202849,-0.05216956,-0.08146526,0.042318642,0.036986377,0.018534316,0.031770483,0.030914897,0.085838,-0.013253374,-0.069084086,-0.0050213775,-0.02372596,0.09325846,0.012249036,-0.008398922,0.0042338106,0.039987933,-0.0060295947,-0.06547731,-0.025846794,-0.005430002,0.021862967,0.09926322,-0.026192363,-0.035527144,-0.0005145377,-0.03450965,-0.15202966,-0.021393837,0.02401316,-0.041591857,0.04508237,0.049838547,0.052638486,-0.06481901,0.089802444,-0.021042816,-0.012613065,-0.106205165,0.09062963,0.009736861,-0.083694145,-0.026426688,-0.03801546,0.008455804,-0.030840376,0.0713187,0.035687443,-0.05874303,-0.04493477,0.018622933,9.847767e-34,-0.010863674,-0.058022637,0.011151961,-0.047261663,0.06841159,0.017989961,-0.046024844,-0.034220923,-0.041100707,-0.045582943,-0.031528946,-0.016376564,-0.010823167,0.14832091,-0.05034603,0.04963027,0.0121968845,0.0054904907,-0.002749811,-0.031099739,0.008643068,0.09554663,0.011803188,-0.017042046,0.04518959,0.015137394,-0.0031161385,0.08059401,0.12172519,-0.0053842994,0.060872868,-0.06998322,-0.118516386,0.008894919,0.044937886,0.018897923,-0.033758096,-0.06744849,0.08305244,0.085563324,0.021036584,0.03771974,0.0285403,-0.06469417,0.016886389,0.03975174,0.008320659,0.0065239277,-0.02362002,0.008424218,0.08955725,0.0031838692,-0.017766247,0.034819435,-0.03443717,0.05100837,-0.042111672,-0.04342998,0.033630893,0.06959936,0.009245207,0.04433609,0.026590988,-0.06525632,-0.029397307,-0.014827019,-0.008746759,0.0057545784,0.051147893,-0.00028129545,-0.081386596,-0.037025303,0.04946401,0.055104427,-0.027060468,-0.067606166,-0.029439788,0.049705084,0.050007652,-0.002106348,-0.040856685,-0.00095244264,0.016096398,0.022674764,-0.040278036,-0.01062996,-0.063746855,-0.080220506,-0.019980997,0.049391642,0.011725232,-0.06676402,-0.049253996,0.05784481,-0.0098981215,-3.9189817e-33,0.12324189,-0.12607905,0.07542852,0.0114370845,-0.047112305,-0.039646026,0.07283961,-0.044386543,0.034722775,-0.0035855935,0.043754146,-0.05783377,0.039454073,0.0002902899,0.034268677,0.0266491,0.00830397,0.11268042,-0.09818724,0.0156846,-0.015785994,0.061267674,0.0658099,-0.03386627,0.053203948,-0.034762967,-0.040696673,0.075863235,0.028743314,0.050195135,-0.033167526,0.011408735,-0.07735691,-0.06551258,-0.04601807,0.01950452,-0.00057170226,-0.02919679,-0.039016746,-0.059179433,0.016981773,0.05877147,-0.058828115,-0.041506402,0.05032217,0.07581526,-0.08278051,0.03155213,-0.02409519,-0.043609034,0.04542985,0.031977437,0.022135677,0.018378265,0.00090872135,0.008946243,0.048149887,0.020762583,0.021644592,-0.045268744,-0.0046048835,-0.06207685,0.04689987,-0.01913284,0.10275955,0.056004893,-0.012046313,-0.014769344,0.015221165,0.0036184138,0.031027792,-0.016564418,0.031648736,0.055025976,-0.006290524,0.029040914,-0.122425206,-0.06843669,-0.0139578255,-0.04745608,0.02672221,-0.023020439,-0.022421174,0.008572106,-0.009463568,-0.060603566,0.08764391,0.09281028,-0.03698744,0.07410387,-0.024129456,-0.028985873,-0.04106264,0.10751208,0.09266183,-3.6683787e-08,0.008327045,-0.0328524,0.016463412,-0.08666437,-0.047743145,-0.0019431935,-0.040610347,0.0015670621,0.058321245,-0.101746164,0.005450218,0.09898931,-0.002494768,0.028205197,-0.026438685,0.011284073,-0.053884223,-0.013750091,-0.010936296,-0.022209458,-0.13077004,0.026670253,-0.10712284,0.03505046,-0.026244365,-0.004173317,0.09293546,0.053769402,-0.0356146,-0.047728576,-0.029488139,0.0475362,-0.008031367,-0.045283787,0.021518387,0.058550768,-0.064351514,-0.045476492,0.007614436,0.014007945,0.04466835,0.019751571,-0.055823974,-0.012034422,0.031816326,0.002245188,-0.022543073,0.045198206,-0.07672714,0.036079638,0.036030404,-0.011873033,-0.052742288,-0.105467744,-0.02175517,0.004286738,-0.10445683,-0.05668047,-0.024336448,-0.01923653,-0.03247082,-0.028562766,0.14042217,-0.06372269 +5.1.3.17,"The enzyme acts on D-glucosyluronate residues in N-sulfated heparosan polymers, converting them to L-iduronate, thus modifying the polymer to heparan-N-sulfate. The enzyme requires that at least the N-acetylglucosamine residue linked to C-4 of the substrate has been deacetylated and N-sulfated, and activity is highest with fully N-sulfated substrate. It does not act on glucuronate residues that are O-sulfated or are adjacent to N-acetylglucosamine residues that are O-sulfated at the 6 position. Thus the epimerization from D-glucuronate to L-iduronate occurs after N-sulfation of glucosamine residues but before O-sulfation. Not identical with EC 5.1.3.19 chondroitin-glucuronate 5-epimerase or with EC 5.1.3.36, heparosan-glucuronate 5-epimerase.",384,1.0,-0.059824973,-0.111250624,-0.011389084,-0.048306894,0.0428138,0.022898806,-0.013100569,0.060655475,0.018200638,0.032179926,-0.0023528067,0.12841377,-0.032887384,0.0378954,-0.091263466,0.034824464,-0.050271306,-0.030518612,-0.023879305,-0.05105,0.13755879,-0.09384813,0.017705303,-0.07587414,0.062029,0.02740848,0.08067945,-0.06432742,-0.019884018,-0.03298454,-0.05384928,-0.076053955,-0.014589301,-0.03596791,0.020526139,0.12226491,-0.07703374,-0.029669646,-0.055204906,0.006523425,0.042858765,0.020961996,-0.059752557,-0.013336728,-0.0046015442,-0.11841367,-0.02967502,0.058436386,-0.04972825,0.020225968,0.041993644,-0.090394996,0.0072859023,-0.024369312,-0.0058130734,0.04992431,-0.044684358,0.028230753,0.010252949,0.014239774,-0.00162205,0.054685663,-0.003683618,-0.07102024,-0.007362686,-0.020777125,0.14184903,-0.08716729,-0.07060002,0.045193437,-0.033818617,0.0630195,0.03611511,0.037379365,0.07187422,-0.013622738,-0.012916407,-0.017582571,0.030926416,-0.057553586,0.059198108,0.094605364,0.023320058,0.075676955,0.024058327,0.027476277,0.02173502,0.06783619,0.044295505,0.01006541,0.03576996,-0.05958244,-0.13301614,-0.014790307,-0.016337126,-0.04773676,-0.014094287,0.10250856,0.05930144,-0.03934027,0.029482918,-0.009911492,-0.024963683,-0.10585198,-0.013903995,0.04473608,0.0076334495,0.10967403,0.05215107,0.021567328,-0.03925095,0.036291797,0.034537982,0.026917402,-0.13944799,0.109479375,0.0014714645,-0.03733609,-0.040985525,0.009924704,-0.009087197,0.006044151,0.059839338,0.046552002,-0.037272055,0.027229384,-0.032598913,4.638169e-33,0.0725525,-0.0260412,0.04066259,-0.0836946,-0.020507645,0.050713196,-0.055405065,-0.006036141,0.013433395,-0.021634694,-0.059599675,-0.035438377,0.034941863,0.0338482,-0.036054853,0.035219602,0.023965642,0.03202445,0.031561,-0.06235563,0.037804984,0.014839833,-0.11771317,0.0035708558,-0.030145543,0.03146594,-0.028449347,0.05566042,0.06603228,-0.0057206433,-0.04419551,-0.11809474,0.0028126694,0.020590689,0.028227989,0.018935597,0.0018668862,-0.029068155,0.060195997,-0.022469511,0.12910599,0.016944688,0.04194373,-0.036617648,-0.0103788795,-0.061995547,0.0019153754,0.051502995,-0.012379579,0.068633996,0.05550429,0.016680852,0.07543057,-0.022968814,-0.07802821,0.055528786,-0.047087707,-0.069384485,0.094489984,0.0070947586,0.051927093,0.0074858414,-0.012593508,-0.036820017,0.021697594,0.017257577,-0.032708425,0.025206061,-0.025754375,0.023836255,-0.05481809,-0.09648985,-0.024040965,0.10219777,0.0072523267,-0.048821833,-0.0008118049,0.07181327,-0.013541739,-0.024371423,-0.041715678,0.002503242,-0.05076929,-0.0049949274,-0.07888566,0.062925324,0.054777786,-0.077417664,-0.014781139,0.03636194,-0.0036503312,-0.10536281,-0.025602242,0.017139034,0.013106361,-6.185798e-33,0.04080784,-0.064492166,0.09358282,0.0039981706,-0.05386312,0.016077116,0.07042542,0.0057786936,0.0064428234,-0.07531402,0.022545403,0.0028595296,-0.0069318316,-0.016117262,0.025396831,0.079554014,-0.10272699,0.07949832,0.00092726987,0.04286784,0.0018601536,0.012941743,0.019545872,0.06785621,0.041907985,0.004645894,0.059164044,-0.020110048,0.023995798,0.10829487,-0.0425069,-0.0015390265,-0.12721479,-0.013522049,-0.047895968,-0.0040419498,-0.026882071,-0.101570114,-0.019341564,0.027879922,0.013654169,0.03422026,0.05982874,0.05903635,0.02181777,0.07154693,-0.066611215,0.026212187,-0.003946333,-0.050928324,-0.03538012,0.062994756,0.011882888,0.033342298,0.022363458,0.06669704,0.06582123,0.003949346,-0.047270577,-0.021563344,-0.077958375,-0.018890172,0.0032778375,-0.038128197,0.04020091,-0.004842584,0.0010743405,0.03421926,0.0063249813,-0.0622208,-0.03434083,-0.022404538,0.004280346,0.011860663,-0.032629993,-0.017394684,-0.048611745,-0.004415077,-0.032784626,-0.078840666,0.06686994,0.01162613,-0.03878503,-0.040264875,-0.010319686,0.022294631,0.050349955,0.108844176,0.007154028,0.07489437,-0.024695149,-0.021557642,-0.045004755,0.06303463,0.048232626,-4.963175e-08,0.009700384,0.039890327,0.034500316,-0.049772207,-0.052831877,-0.031026455,-0.024881635,0.0006833492,0.029611208,-0.039338082,0.018797357,0.0888771,-0.056858435,0.018226601,-0.053680383,0.026741685,-0.042793997,0.027113099,-0.017259376,0.034618292,-0.13181797,-0.02409812,-0.04872181,0.009991635,0.0495788,-0.057267487,0.07910335,0.0728379,-0.035236716,-0.0037513317,-0.056035057,0.048704363,-0.02665856,-0.063334025,0.024696779,0.059735794,-0.00096339185,3.1997995e-05,-0.02601965,0.023257105,0.037595026,-0.021817004,-0.0069130007,0.022826446,0.011595079,-0.06578102,0.010046852,0.03310271,-0.013645016,0.058001153,-0.016535968,-0.06817454,-0.06565498,-0.1620233,-0.041608516,-0.026359648,-0.028933683,-0.04359951,0.06911936,-0.03418641,-0.03801114,0.0059312596,0.0913433,-0.039912537 +5.1.3.18,"The enzyme catalyses the formation of the stable intermediate GDP-beta-L-gulose as well as GDP-beta-L-galactose. The reaction proceeds by C4' oxidation of GDP-alpha-D-mannose followed by epimerization of the C5' position to give GDP-beta-L-4-dehydro-gulose. This intermediate is either reduced to give GDP-beta-L-gulose or the C3' position is epimerized to give GDP-beta-L-4-dehydro-galactose, followed by C4' reduction to yield GDP-beta-L-galactose. Both products serve as intermediates in two different variants of plant L-ascorbate biosynthesis pathways.",384,1.0,-0.007439798,-0.04616458,-0.05009888,0.035192087,0.09615347,0.12278961,-0.06846323,-0.013972443,0.02333343,0.018244594,0.0734746,0.030870333,-0.061463438,-0.06268259,-0.09905764,-0.0024793663,-0.04126215,-0.012462418,-0.033605415,-0.046029113,0.12300501,-0.051376514,-0.0030869334,-0.022275757,0.11741419,-0.07799936,-0.019199338,-0.12865786,-0.031049268,-0.12257725,0.0058007417,-0.06971847,0.04450185,0.015482245,-0.0008417711,0.036434703,0.025933692,-0.051733065,0.07280845,0.01814681,0.00014278249,-0.05290135,-0.027589917,-0.0008793132,-0.05297822,0.049687613,-0.02695029,0.011190531,-0.017205806,-0.02328574,-0.008304794,-0.008210483,-0.045253802,-0.02952854,-0.045894954,0.06714674,-0.015972601,0.017677631,0.0012904622,0.07150299,0.07716984,0.028154172,-0.04200415,-0.030418558,-0.034760408,-0.05437613,0.02470267,2.0176565e-05,-0.026157068,-0.005337535,-0.012735228,-0.065885685,-0.05695606,0.010312879,-0.0064271498,0.06483322,0.009091071,-0.014314338,0.034497418,-0.030092271,0.079985455,0.052041035,0.029178634,-0.028376421,-0.00021978942,-0.04390217,-0.044553906,0.05544858,0.088094436,0.026397547,0.049785163,-0.034811113,-0.032510486,0.046404716,-0.025503572,0.07780146,0.086422116,-0.033545785,0.061845183,-0.06100673,0.006254341,0.053245552,0.033757217,-0.04677722,-0.003147072,0.048371747,-0.047503408,0.04026646,0.061790694,-0.031187017,0.015222676,0.036044672,-0.0068647545,0.03688507,-0.07046688,0.051599704,0.015918694,-0.088240966,-0.03791076,-0.05185108,0.10658658,0.04619132,0.023448704,0.042504422,-0.04591217,0.057638112,-0.030602982,8.586902e-34,0.06538662,0.06417031,-0.039751865,0.02214364,-0.004574396,0.024305655,-0.09814513,-0.0016400237,-0.04858225,0.06332689,-0.09866261,-0.07180572,0.0004671338,0.05538896,-0.02545976,0.03746835,0.020338895,-0.047723938,0.06478447,0.010059257,-0.04056451,0.02877749,-0.09178824,-0.003373514,0.052421052,0.029257827,0.03280272,0.04394291,0.06556616,-0.021307552,0.028411759,-0.038764324,-0.022811899,-0.02062198,0.08793282,-0.039316077,-0.017646508,-0.04009176,0.031893384,0.001449936,0.034380265,0.08386391,-0.020981887,-0.038371462,0.026695939,-0.010172022,0.0017579597,0.027206339,0.05382674,0.0583917,0.03285995,0.024009617,0.05550771,0.053519916,-0.018808592,0.043505017,-0.08569077,-0.050029937,0.031193346,-0.023263808,0.059241075,0.02537039,-0.028461657,0.0027039764,0.029887874,0.04000424,-0.05540664,0.010719263,-0.025130272,0.08543032,-0.085065395,-0.15269054,0.07496477,-0.035806604,0.041355524,-0.01311534,-0.07833806,0.030513223,-0.023802157,-0.029281827,-0.059080448,0.08221848,-0.052594207,-0.0018286546,0.036965083,0.011990175,-0.020749077,-0.0062902938,0.062409066,0.023864217,-0.020755654,-0.0038241516,0.006203573,0.04194679,-0.0019968133,-2.0011893e-33,0.103672735,-0.086395666,0.0662313,-0.02347398,-0.04061416,-0.0025214788,0.04957574,-0.12688705,-0.0062144557,-0.03897036,0.03577399,-0.0063111917,-0.013742903,-0.043139026,0.075496085,0.008083968,-0.0006898827,0.08616998,-0.0868169,0.058892637,0.019756066,0.0739263,-0.00442685,0.048859656,0.05359835,-0.03207742,0.03582581,0.051120684,0.045260362,0.009259821,0.037778925,-0.05331384,0.003378547,-0.07339835,-0.0689371,0.014712151,-0.066324584,0.021905927,0.0070180274,0.016904067,0.015641797,0.050850086,-0.012336272,0.011726657,0.1063152,0.06520953,-0.073758386,0.012321151,0.029124146,-0.04503389,0.04640147,-0.05791845,-0.07258831,-0.026282389,-0.0016751048,-0.002327204,0.029002426,-0.016731659,-0.04092972,-0.05864119,-0.03516198,-0.045034885,0.089858174,-0.058873937,0.035342053,0.048822165,-0.007217033,0.0823745,0.053049937,-0.008247781,-0.0058082305,0.0011041441,0.008478703,0.048298724,0.011451777,-0.0071024373,-0.12755786,-0.061153434,-0.023243312,-0.014965442,-0.028140847,0.057486538,-0.0066115833,-0.09388271,-0.059405513,-0.06228008,-0.019534668,0.13306184,0.062649444,0.04024167,-0.09309842,-0.05085015,-0.015414036,0.07379159,0.09055832,-4.1927184e-08,0.03476285,0.049442675,0.047315057,-0.0732012,-0.04946666,-0.012174296,-0.011085859,0.005343434,0.055355262,-0.08098695,-0.015439558,0.115611196,-0.028526755,0.021257594,-0.013042354,-0.0079363305,-0.0667662,0.05146294,0.0042379913,0.07891325,-0.022421781,0.029231247,-0.08037787,0.033300463,0.03396859,-0.07784801,0.03671359,0.065528095,0.008049929,-0.0027141895,0.1008474,0.06558232,0.07843942,-0.032816537,-0.046791814,-0.019308424,-0.016060224,-0.004004446,0.05671254,-0.0031727136,0.020104118,-0.07190401,-0.013026502,0.03213741,-0.09161543,-0.038311638,0.021550832,-0.02471248,0.0021005066,0.08256215,-0.008105672,-0.046169717,-0.094392985,-0.040361706,-0.007578305,-0.04519247,-0.021978578,-0.03864664,-0.0072254296,-0.110038325,-0.012616919,-0.08317792,0.10721486,-0.06420948 +5.1.3.19,Not identical with EC 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase.,384,1.0,-0.052698907,-0.04260619,0.024959296,-0.04192198,0.11543713,-0.0440133,-0.0038247267,0.052191414,-0.0053963796,-0.037860055,0.033707622,-0.01381591,-0.03386468,-0.0007560055,-0.053097084,-0.06528635,-0.00023780206,-0.10015878,-0.0146988025,-0.03164787,0.053022392,-0.01854393,0.046426382,-0.0032495696,0.065945156,0.077206895,0.04021232,0.052476708,0.00093192153,-0.094830364,-0.0016547696,-0.050888047,0.04831353,-0.06639491,0.009690599,0.099361256,-0.034307823,-0.014679845,-0.04753637,0.009236518,0.025806598,0.026142048,-0.03842674,0.032025483,-0.020413226,-0.065789014,-0.074517034,0.11467047,-0.011433632,0.011542588,0.02127145,-0.11201269,-0.055004004,-0.022495432,0.016079688,0.0145426495,-0.08081943,0.02640626,-0.011374526,-0.04437727,0.020618847,0.015363018,-0.026224317,-0.02485313,0.010813123,0.05696364,0.12816186,-0.16031109,-0.047607124,0.063177295,-0.017774628,0.025961898,0.051383574,0.10811491,-0.030032007,0.032913864,-0.0019518939,-0.035194777,0.007719899,0.016507013,-0.05293474,0.040366508,-0.002284481,0.047485273,-0.00765454,-0.042744268,0.0021731602,0.0075264005,0.0018213575,-0.044094753,0.061359007,-0.036334515,0.018250111,1.3564329e-06,-0.076320805,0.037134696,-0.060484648,0.14098258,0.054720722,-0.018708419,0.019176485,0.039330382,-0.05081786,-0.066954195,-0.002302113,0.08795897,-0.013857065,0.054158833,0.031523254,0.017729666,-0.06362951,-0.03567368,-0.008286848,0.0008672799,-0.10275826,0.06684674,-0.01277247,-0.025520043,0.008551891,0.06550662,0.033745997,-0.012463837,0.08188229,0.03039144,-0.07321799,-0.014747878,-0.0362633,6.1209456e-34,0.010094693,-0.04770549,0.09212492,-0.056009617,0.0024810438,0.07138124,-0.06060754,0.010935579,-0.01792296,-0.075236954,-0.09793056,-0.009058464,0.037961535,-0.037263922,-0.038659725,0.0054772575,-0.07212533,0.050456196,-0.014720939,0.007974318,0.0598432,0.039400853,-0.07883427,-0.027545506,-0.014286194,-0.0020605105,0.020650877,0.033694692,0.10695632,0.0014789745,-0.055067413,-0.070907556,0.02964136,-0.009725551,-0.039580397,0.01226385,0.034849297,-0.037325293,0.048694782,-0.005629221,0.08226101,0.061065353,0.07920739,-0.024975125,0.0145882815,-0.09420861,-0.042991664,0.026757723,0.04148859,0.02423654,-0.004610446,-0.027038587,0.050231572,-0.0037167144,2.7203225e-05,0.061713096,-0.008426677,0.037773635,0.0583446,0.03854184,0.07728408,0.107375234,0.02762622,-0.03832389,0.017246287,0.06627697,-0.014071,-0.012351046,-0.022120446,0.045592844,-0.035961874,-0.0033294517,0.030568175,0.11379789,0.031682495,-0.09262621,0.001968401,0.05539223,-0.04979182,0.040295016,-0.10794445,-0.05565577,-0.011644144,-0.0011045609,-0.12970674,0.081040025,0.03453031,-0.05686288,0.007779607,0.04880474,0.060504816,-0.052575946,-0.043403298,0.0064974404,-0.05317428,-1.3309416e-33,0.006003252,-0.046006188,0.07509249,0.04505282,-0.031907775,0.027294815,0.007921982,0.0349786,0.0555694,0.0057728877,0.11310749,-0.037912354,-0.03605988,-0.06572588,0.034945924,0.10018956,-0.0013297673,0.090888344,0.0063201278,0.036173705,-0.014900625,-0.0003291643,0.02068346,0.019770443,0.034622993,0.0034211332,0.0694561,-0.01629966,-0.0018475818,0.043457516,-0.064777225,-0.009343456,-0.11091916,-0.021013686,-0.032468684,-0.040131547,-0.039922446,-0.08824102,-0.008137846,-0.05545801,-0.017784344,0.05775042,0.062676534,0.059494928,0.0026428208,0.08887031,-0.032154292,0.069874935,0.036969423,-0.04026352,-0.05550091,0.005128251,-0.022517586,0.06170959,0.0050996183,-0.01939921,0.07047302,0.057329524,-0.06910837,0.023757977,0.0051575126,0.011356031,-0.015304455,-0.052190278,0.08250277,0.02165553,-0.07475096,0.01807741,-0.00012855158,0.042409535,-0.040239424,-0.1152944,0.0009320342,-0.003820369,0.012081201,0.01670219,-0.005812538,0.012509986,-0.049013104,-0.0666052,0.094563976,0.02268466,-0.038821496,-0.025897598,-0.025255417,0.051553093,0.017443748,0.07135096,0.00242416,0.14175536,-0.06950426,0.0101694595,-0.07778189,0.03318601,0.06539934,-2.651005e-08,0.09356895,0.0015691811,0.027780648,-0.050930783,-0.036304936,0.0026904917,-0.07487441,-0.04479259,0.0630573,0.025778119,0.011497908,0.028834254,-0.01511012,0.007041557,-0.06875669,-0.012182872,-0.036904167,0.050107144,0.0046352395,0.019370746,-0.13016003,0.024597146,0.02687406,-0.070163645,0.00950479,0.02910882,0.0788744,0.07400414,-0.03928137,-0.028649084,-0.032020573,0.02620957,-0.015046197,-0.04757269,0.016811997,0.06683002,-0.03436362,0.05396166,-0.069010004,0.065200455,0.009862403,-0.05933128,-0.03422903,0.0019370549,0.024408251,-0.052849557,0.047633167,0.021640524,-0.006522989,-0.05065466,-0.04096547,-0.023442889,-0.040555123,-0.1242497,-0.039197847,-0.020951696,-0.05181126,-0.07960839,0.077928975,-0.024355365,0.007830567,-0.08339962,0.07473084,0.07000284 +5.1.3.20,Requires NAD+.,384,1.0,-0.06878425,0.022418711,-0.053952727,-0.016134635,-0.04897264,0.06289609,-0.030143915,0.010669343,-0.003183227,0.03938317,-0.02209948,-0.014993911,-0.058369208,0.08770232,0.005057102,0.018540792,-0.004241495,0.026848016,0.021070817,0.025145229,0.051068284,0.003422877,0.072723284,-0.01820859,0.06801252,-0.013825288,-0.049557935,0.027358204,0.089087516,-0.050625946,-0.026951827,0.042057585,0.003714755,-0.041774,-0.07487685,0.008750964,-0.06711072,-0.0015589169,-0.026578454,0.033997674,0.0069180927,-0.060703434,-0.03088875,0.0866388,-0.01877226,-0.082746536,0.016040761,0.043075323,0.05287882,0.013214744,-0.08002864,0.011352289,-0.028130516,0.013129261,0.051064674,-0.040237524,0.0043854923,-0.020197976,-0.019096883,-0.031847764,-0.038290802,-0.07046345,-0.08907335,0.0492619,0.0845278,-0.0030918056,0.033161044,-0.0016798137,-0.041360088,0.04743689,-0.08996856,0.03448865,0.008086315,0.04895464,0.0033891012,0.07331984,-0.083484225,-0.059768118,0.12877707,0.019068506,-0.036896434,0.022171225,-0.090521745,0.0069394433,0.14800002,0.05467556,-0.026208809,-0.025799705,-0.048744645,-0.0059925215,0.0026595385,-0.019939635,-0.009184698,0.060988102,-0.07809198,0.0057957186,0.02040638,-0.013456087,-0.054213773,0.062357537,-0.018138552,0.08147702,-0.042604342,0.017021615,-0.057537433,-0.02113984,0.02836716,0.07532199,-0.060083464,0.02279571,0.0018487689,0.008646811,0.03698565,-0.059036586,-0.06920008,0.09812879,-0.020373061,-0.006502994,-0.022361793,-0.056976307,-0.03316445,-0.0074004014,-0.016645474,0.0037570226,0.0081338165,-0.050095916,-0.0056487187,-4.6826648e-33,0.09235815,0.05338163,0.011236184,0.10115843,0.0053777806,0.060964406,-0.07489847,-0.0071162726,-0.060803924,-0.07005021,-0.06295462,-0.077826686,0.012041837,-0.018896807,0.10158911,0.052189797,0.019164147,-0.050406016,-0.034262966,-0.047203273,0.04309886,0.024661193,-0.02269407,0.028002527,-0.0012545489,0.05890502,0.034546826,0.0029719756,-0.019439071,0.027478365,0.04855415,-0.091883585,-0.10473347,0.013965188,0.030152159,0.054002997,-0.072750494,-0.042713985,0.03639799,0.04479241,-0.07412687,0.07226459,-0.02366356,-0.037748724,0.037109118,-0.079526655,0.074475884,0.10534082,-0.010932426,0.07541058,0.012110492,-0.0028663273,0.05779693,-0.016673632,-0.016755233,0.075922236,0.047118027,0.023571553,-0.00023787416,0.13184592,0.025702558,-0.010675333,0.008317998,0.0952034,-0.13331889,0.011129972,-0.1063271,-0.063091435,0.04861221,0.02580615,-0.00073961064,0.0142752025,0.022426242,0.008276227,0.030087216,-0.03927804,0.0493954,-0.04884962,0.039260026,-0.013528945,-0.047771476,-0.035876106,-0.036817458,-0.003507331,-0.0096555045,0.008722018,0.0291098,-0.03092306,0.004282515,0.05048849,0.015952094,-0.050346527,0.0039171963,-0.07538181,0.0059954314,3.5683005e-33,0.00866626,0.023690503,0.03318855,-0.03830764,0.056684222,0.03794229,0.04440472,-0.15212803,-0.02121104,-0.033166327,0.027741728,0.06639345,0.016479481,-0.027978659,0.041975386,0.011642394,-0.04727861,-0.042929877,-0.016661396,0.005573803,0.031086456,0.14377128,0.057882022,-0.013367941,0.016548494,-0.0073285582,-0.059595108,0.072514884,-0.034135524,0.020862656,0.02821628,-0.030110646,-0.14643662,-0.033864122,-0.026493056,-0.0015618297,0.037779097,0.0329752,-0.07400528,0.073723495,0.048474837,-0.014463436,-0.0652607,0.121435285,0.037335522,0.013210648,0.0090542305,-0.063324176,0.059819736,-0.006296046,0.014621462,0.03049263,-0.070291854,0.013424272,0.03866232,-0.0307609,-0.05184867,0.03840256,0.044075005,0.018195717,0.010647509,-0.004967439,-0.0071593733,-0.083262466,0.08556599,-0.0160003,-0.012172486,0.03631846,0.06073557,-0.00946426,0.010774417,0.0719881,0.027298948,-0.043068673,-0.024945745,0.014567179,-0.095189996,0.06947878,-0.0030031013,-0.045961633,-0.10132435,-0.04427107,-0.034111977,-0.049235493,0.06295752,-0.037940934,0.097294465,-0.08145694,-0.03951798,0.033203676,0.0103231,0.065752484,0.03948528,0.0598022,-0.039136365,-1.3636822e-08,0.011917494,1.4096073e-05,-0.008929148,-0.041335754,0.01597744,0.044829488,0.043431498,-0.05939643,0.005649463,0.084154725,0.10219487,0.067879215,0.10947128,0.08929933,0.055047493,-0.042749062,-0.027997252,0.044140235,-0.13267457,-0.0592836,-0.08438197,-0.0096346075,-0.062240858,0.13391991,0.02083735,-0.025069138,0.04183365,0.008890681,0.07415759,0.014711216,0.04590546,0.021397868,0.031297743,-0.031419184,-0.051015496,0.0878698,0.015182229,0.055078547,-0.0017691129,0.03071403,-0.060774803,-0.022852689,-0.034646098,0.04620306,0.007813158,-0.0061408314,-0.030427601,-0.0584266,-0.059588622,-0.05647291,0.051814128,-0.0064982073,0.020516653,-0.029650392,0.0017921664,0.040331192,-0.00051787606,-0.008993585,-0.007561174,-0.049609452,0.09806808,-0.03033586,0.064939894,-0.0472908 +5.1.3.21,The enzyme catalyses the interconversion of alpha and beta anomers of maltose more effectively than those of disaccharides such as lactose and cellobiose.,384,1.0,0.023764106,-0.11069121,-0.035031006,0.072989665,-0.016263321,0.060783304,-0.021536253,0.0114663,0.06925631,-0.011074945,-0.004793546,0.0193252,-0.09705449,0.012571343,-0.052487057,0.024730805,-0.022552753,0.01688591,-0.03604955,-0.051813763,0.032070883,-0.06814221,-0.066688664,0.03908058,0.07482691,-0.032202948,-0.00040690202,-0.013576183,-0.021369254,-0.07124576,-0.018235978,-0.107014574,0.09720495,0.01835521,-0.01930517,0.0930861,0.028774643,-0.053757563,0.032862347,-0.07463141,0.03681224,0.0051269997,0.042977877,0.040269617,-0.080035254,-0.011259471,-0.084893204,0.060238246,0.002242907,-0.006546038,-0.120118625,-0.060986303,-0.057968516,-0.04531493,0.0035869258,0.07208468,0.016759234,0.04657386,0.018155342,0.033070717,-0.04760634,0.08203774,-0.0019280264,0.042953067,0.007574693,-0.0638066,0.0730868,-0.06372472,-0.09483045,-0.0025994065,-0.06923803,-0.061582215,-0.05917253,-0.035967324,0.07296686,0.007226572,-0.05072054,-0.03105463,-0.03922696,0.07260289,0.021776732,0.005348464,0.020321267,0.09428814,-0.01964233,-0.11454848,0.056370683,-0.046741813,0.05577214,0.010590809,-0.013797528,0.013770161,0.037949268,-0.024342582,0.0030739957,0.012331994,0.017182099,-0.02196661,0.077844836,-0.037322327,-0.042287037,0.005462231,0.026753377,-0.039652873,-0.07569666,0.0856813,-0.011306724,0.03642324,0.089484006,0.04766337,0.06019155,0.043038905,0.05138399,0.028340552,-0.060490254,0.057774443,-0.018886188,-0.047462128,0.064799875,0.004089739,0.004466579,-0.027390553,0.081303895,0.07995424,-0.062343623,0.01849743,-0.062558785,2.1060107e-33,0.004061491,-0.006967774,0.02719138,-0.010535878,-0.018319225,-0.026270576,-0.08357589,0.03776468,-0.006788256,0.0004606827,-0.08634071,-0.061015982,0.041455124,-0.001267444,0.04234274,-0.04553483,0.038983345,-0.049709316,0.006031819,0.09567812,-0.043933455,0.0012240526,-0.02855493,0.000928255,0.05777642,0.035608742,-0.005066255,0.008726972,-0.04123439,-0.026851324,0.04786602,-0.023740038,-0.056430973,0.03889074,0.051241167,0.0563405,-0.03525844,0.030478107,0.02712861,-0.0049317223,0.0017809037,0.030121595,0.01567855,-0.08452333,0.079141214,-0.03141647,-0.026452515,0.019041624,0.011362144,0.036695085,0.009892288,0.0072316783,0.0030531613,0.03096502,-0.018283904,0.06521147,-0.04390761,0.043613967,0.00051527185,0.076489694,-0.015535851,0.02910622,0.029702744,-0.04422147,0.013752132,0.002054,0.027937237,-0.027472222,0.0038993396,0.0713725,-0.14248501,-0.0008437037,0.055284265,-0.019451058,-0.03461693,-0.05014818,-0.07198554,0.02560405,0.09001521,-0.051626414,-0.010333264,-0.018056683,0.011215422,-0.03001722,-0.08578632,-0.003104505,-0.04359685,0.04180597,-0.010255428,0.043599777,0.03911187,-0.02126316,-0.03358625,0.026799548,0.053310733,-4.765986e-33,0.12455571,-0.17436247,0.045039717,-0.05516312,-0.07139942,0.0008322307,0.050233286,-0.1028975,-0.011673938,0.019554712,0.019042917,0.05914952,0.0036457279,-0.09113783,-0.025686376,0.09847104,0.019926392,0.10137361,-0.029887639,-0.019528134,-0.00034130935,0.14205371,0.025926657,-0.029313086,0.007364534,-0.036444966,-0.01580251,0.10825082,0.047687948,0.04191896,0.012002131,-0.027688993,0.032297652,-0.13338977,-0.05525784,0.05472197,-0.11076316,-0.024972653,0.017502254,0.03467234,0.0009613482,0.12238116,-0.02536547,0.0074537164,0.077086985,0.08751843,-0.054739505,0.027232131,0.018250791,-0.010744056,0.023908172,-0.03360776,0.00844841,0.0038948492,-0.058058053,0.029188,0.025503805,-0.026784066,-0.05399807,-0.024339015,-0.068811305,0.0056528547,0.08594278,-0.071620554,-0.022212328,0.005946313,-0.078150965,-0.008266734,0.03528382,0.022270562,0.008947133,-0.029479697,-0.004420902,0.064880475,-0.043481503,-0.045352746,-0.090918064,-0.052711118,-0.023059666,-0.031203307,-0.020244539,0.10704627,-0.028144788,-0.021207081,0.027469086,0.005124313,0.017664261,0.06319415,-0.00071665377,0.047232427,-0.0016414571,-0.015808903,0.03752028,-0.017946767,0.10323811,-2.797459e-08,0.058848247,-0.038857568,-0.034551248,-0.02099182,-0.016061101,0.014041044,-0.026485452,0.0019527973,-0.018384568,-0.019398438,-0.031268556,0.0886585,-0.052911934,0.07956365,0.030430844,0.03380641,-0.020882007,-0.034935016,-0.022572497,0.051611286,-0.08015502,0.0068935556,-0.08596505,0.02833323,-0.027470285,-0.045583583,-0.020488815,0.0021839084,-0.060284466,0.026188936,0.03659616,0.08798052,-0.0044802367,-0.06855041,-0.017193178,0.025839565,-0.020716414,-0.07187472,0.035932463,-0.022403788,0.06127376,-0.05417261,-0.045054805,-0.0075095478,-0.009713469,-0.0028007799,-0.009993729,-0.038033165,0.016238203,0.07999116,0.030911377,-0.014371313,-0.06987919,-0.016692052,0.035752047,-0.053306427,-0.010600748,-0.0075791143,0.025660183,-0.07677498,0.096197985,-0.0399377,0.17109758,-0.13421611 +5.1.3.22,"Along with EC 4.1.1.85, 3-dehydro-L-gulonate-6-phosphate decarboxylase, this enzyme is involved in a pathway for the utilization of L-ascorbate by Escherichia coli.",384,1.0,-0.05369307,-0.05977176,-0.072797015,-0.015388659,-0.018578695,0.035175506,-0.0725193,0.045903888,0.020853903,-0.024492482,0.07881707,0.008770897,-0.11083193,-0.0008510868,-0.042087603,-0.0063692764,-0.024048481,-0.008143095,-0.03441123,-0.04542763,0.13182953,0.042080995,-0.03841554,-0.0350133,0.071706116,-0.001872999,0.041016866,-0.060960002,-0.02869637,-0.124268554,0.03765052,-0.04657949,0.047109786,0.0071161096,0.056813773,0.10063632,-0.049337476,-0.11198857,0.11499538,0.094219185,0.01362188,-0.018979529,0.054532662,-0.021273812,-0.020589584,-0.028303754,-0.0427459,0.040857796,0.011778952,-0.05310253,0.011899359,0.022548757,0.004034301,-0.038511362,-0.059778776,-0.019479474,-0.043752067,-0.019175539,-0.08807662,0.0813435,0.04391542,0.06339642,0.02538508,-0.017855272,0.0044065756,-0.038269795,0.053126093,-0.017370805,0.03323622,-0.00088927726,-0.05932603,-0.06398348,0.033816066,0.02313992,-0.028009946,0.043060973,-0.0055193626,-0.033580437,0.04602866,-0.027771017,0.10993094,-0.018243257,0.012932917,-0.0077000186,0.026527584,-0.04750936,-0.027327353,0.053870976,0.04766791,0.09599237,0.06249961,-0.057573203,-0.03664878,-0.0025689087,-0.045361154,0.049009662,0.028840566,-0.015817106,0.014426391,-0.041589025,-0.0013903548,0.06247156,-0.054521892,-0.010332382,0.046242468,-0.025653243,0.023021251,0.06273962,0.013888581,-0.013922269,-0.05348275,-0.004262217,-0.0008756043,0.018506577,-0.0022325858,0.08542323,0.028199589,-0.056783855,-0.005653344,-0.037412874,0.0896472,-0.049088977,-0.0024888958,0.04793024,-0.05993768,0.05037473,-0.06660971,-2.1953585e-34,0.05059385,0.01890368,0.023571085,-0.0026849462,-0.03740427,0.04392334,-0.101551265,0.0241399,-0.11712643,-0.06506434,-0.046161663,-0.02124544,0.044363227,0.06203645,-0.04137117,-0.041951135,-0.04791457,0.04459258,0.025413636,-0.040082376,0.06908114,0.026160628,-0.08015204,0.092543036,-0.06405577,0.03878884,0.006610757,0.03138054,0.032307964,-0.008869725,-0.015888518,-0.081400394,-0.051399287,-0.023003714,0.095342316,-0.02412046,-0.073795974,-0.033672243,-0.0019960713,0.028974906,0.009832327,0.058817726,-0.033208873,-0.03404409,0.008456009,-0.033615433,-0.020334205,0.035273522,0.054228514,0.026620463,0.03509506,-0.007514247,0.07270434,-0.009175705,0.0196464,0.0069214073,-0.084798306,0.045245275,0.073485926,-0.02613424,0.077696815,0.01206016,-0.080384195,-0.019906754,0.022487072,0.027152855,-0.04405608,-0.03668396,0.01428789,0.11180396,-0.08750516,-0.08249828,0.042876057,0.005408325,0.008775317,3.762045e-05,-0.07822362,0.06381469,-0.051232997,-0.005552937,-0.02583887,0.04043539,-0.002153831,-0.04045511,-0.030945584,0.028751908,0.003678098,0.026767965,0.065060355,0.026241604,0.04047321,-0.039003804,-0.05976609,0.01747792,0.032403164,-1.35074045e-33,0.09508914,-0.052909106,0.049453653,-0.007906655,-0.05821275,0.032894917,0.073685855,-0.030008018,0.054377917,-0.012574895,0.029554797,0.025570327,0.072719745,-0.06534922,0.104109645,0.017949978,-0.043799184,0.03375424,0.0013276273,0.040849295,0.0056024506,0.08428976,0.038942438,0.041992504,0.044579424,-0.038350403,0.003040761,0.0058182348,-0.028178377,-0.0017092628,0.0028660959,-0.0072516976,0.020174762,-0.036352616,-0.14804365,0.0069415076,-0.032239486,0.0399099,-0.019010335,-0.024584165,-0.0059684487,0.053616345,0.023784837,0.082807496,0.06424996,0.054080706,-0.023101298,0.016619738,0.03023782,-0.0026241175,-0.016701886,-0.03306415,-0.047539555,-0.029536568,0.019628461,0.0005773173,-0.019443516,-0.064611025,-0.019092603,0.021845177,-0.03692121,-0.07678574,0.017432647,-0.078759834,0.066649415,-0.010929444,0.013442418,0.09711648,0.06354239,-0.06863406,0.11892513,0.07188257,-0.020232197,0.003939128,0.012964484,-0.09888277,-0.1503071,-0.025531847,0.016607188,-0.0255578,-0.07487061,-0.00035233816,-0.021926789,-0.04563859,4.9588125e-05,-0.115198895,0.06314566,0.12202899,-0.024133768,0.052910022,-0.07640618,-0.089474745,-0.03455166,0.08469041,0.05022938,-3.369555e-08,0.0397412,-0.008280625,0.0073600207,-0.04476849,0.046479065,0.055582743,0.0149656935,0.07443417,0.04299776,-0.045431033,0.05186411,0.039821673,-0.014792554,0.013619239,0.04527873,0.0141984485,-0.0817816,0.06691954,-0.009598587,0.035802294,0.06081399,-0.033946443,-0.08432072,0.03480282,0.031917483,0.051523138,0.047343396,0.07953839,0.03006833,-0.07126946,-0.015571586,0.024775015,0.08247438,-0.042736426,-0.07861767,0.0041103694,-0.06387069,-0.01845758,-0.011758584,0.06879229,0.01566591,-0.07163639,-0.03138999,0.023017414,-0.07798265,0.07577559,-0.020278245,0.020979568,-0.041807428,0.021509957,0.01605907,-0.08113805,-0.04623288,0.040593743,-0.064303696,-0.014635978,-0.038113967,-0.07010674,-0.0080646025,-0.09127877,0.03741591,-0.008561219,0.16613562,-0.03416542 +5.1.99.4,"alpha-methyl-branched acyl-CoA derivatives with chain lengths of more than C10 are substrates. Also active towards some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA. Not active towards free acids",384,1.0,0.008886855,-0.13125442,-0.0704997,-0.05177326,0.03950001,0.06996433,-0.059533425,0.061468244,0.07263127,-0.045989014,0.1120453,-0.038042743,-0.023826992,0.052234977,-0.0053629335,0.009539115,0.00034710523,-0.013450507,0.015512074,-0.011022896,-0.123088196,-0.016562277,0.011254795,0.06382439,-0.036440354,-0.015173286,0.0529062,-0.048431177,0.054840576,-0.020143254,-0.0034653859,0.0032282285,0.048847973,-0.009303674,-0.016902136,0.022349438,-0.043395594,-0.051115267,0.007620032,0.0587832,0.020632353,-0.06571292,-0.02707394,0.0075655635,-0.0173304,-0.0944726,-0.010223413,-0.005824617,-0.0059029455,0.027249752,0.031305593,-0.0005148456,-0.089684404,0.075947024,-0.0091566825,0.027691655,-0.06865642,-0.03709407,-0.0065341485,0.10461058,-0.0035378663,-0.025393166,0.0062965523,0.025283333,-0.04892429,-0.0069984924,0.017888643,0.0035316795,0.071120635,0.0054687066,-0.087109864,-0.082411654,-0.0124224955,-0.017384132,0.043445483,-0.0022234786,0.0024985375,-0.0714858,0.04375429,-0.09184585,-0.07853574,-0.025467053,0.0039312025,0.09769886,0.03893685,-0.028379444,-0.033009857,-0.03916248,-0.016493976,0.03142471,0.026615912,0.014998986,-0.007824367,-0.04982181,-0.058221787,0.015474179,0.05649257,0.003133105,-0.05387234,0.03232406,0.013500141,0.0757901,-0.04829669,-0.02730149,-0.10195288,-0.020006321,0.026707169,0.0082087265,-0.016334144,0.008633858,-0.009238066,-0.035689488,-0.0021577145,-0.06323493,-0.08733348,0.0006610924,0.017397407,-0.10863051,0.010387024,0.019302724,-0.0106257275,-0.024154428,0.035833187,0.048279196,-0.022295212,-0.011546607,0.017861167,1.4275394e-33,0.04475905,0.034079514,0.025528228,-0.015145423,-0.01483894,-0.013557073,-0.07581784,0.009378543,-0.009266302,0.010802856,0.05088082,0.09640315,-0.006083302,0.07355463,0.098648034,-0.055671494,0.03839862,0.06159039,0.05291211,0.008600478,-0.022835338,0.021880992,0.011631229,-0.014152968,0.048997294,-0.03125978,-0.08642266,0.077609874,-0.045951292,0.018353332,-0.049038753,0.035737287,-0.037492517,0.034082543,-0.027314167,0.036253776,-0.14421798,-0.009124297,-0.0046634856,0.054615587,0.074964605,-0.008012388,-0.00668476,0.00143414,0.026506519,-0.06092112,-0.059814624,0.05178275,-0.048567515,0.036449276,0.019330705,0.0001893182,-0.0005536444,-0.049685553,0.007120055,0.00066899427,-0.108360164,0.013340362,-0.026998132,0.024984652,0.00868892,0.07730699,-0.12463322,0.054547764,-0.053524338,0.0026067002,-0.10107026,-0.038329583,-0.042245455,-0.033221714,0.02001098,0.037277438,0.04271705,0.055100203,0.026352534,-0.030065373,-0.1016467,0.004160986,0.06894554,0.044311356,-0.010360694,-0.029674781,0.053214796,0.019717474,-0.061034687,-0.004217258,-0.020058025,-0.0057610315,-0.0062410953,-0.025425626,-0.06421704,0.008098798,0.0074515305,0.03778703,0.07005961,-4.062586e-33,0.08413659,-0.121621646,-0.05318235,-0.11493827,-0.039525725,0.07169426,0.059321452,-0.05154441,0.06030974,-0.011934154,0.0863137,0.0564825,-0.08780888,-0.07066743,0.018213954,-0.033074904,0.0427102,0.06560751,-0.06675827,-0.023332104,-0.0061856373,0.027321868,0.025308792,0.057208546,0.02745613,0.015616651,0.00025218062,0.00025927855,-0.00092132896,0.1486691,-0.03466449,0.023650272,-0.008486615,-0.013138559,-0.0234131,0.042557713,-0.002400859,0.0061519207,-0.05565756,0.0064109284,0.017754069,0.03372547,0.043481264,0.026262691,0.013811608,0.024693971,-0.06526793,-0.0069498303,0.020324351,-0.035306133,-0.0015099352,-0.01022991,-0.024227766,0.010343895,0.033014044,0.10993731,-0.06643573,-0.030329503,0.045370728,-0.13763876,-0.07019313,0.060277723,-0.06813311,-0.086520694,0.02671251,0.008436006,-0.036517777,0.037340276,0.05194091,-0.053330697,0.07784907,0.09960095,0.032771777,-0.032270946,-0.06004668,-0.04277297,-0.0019039661,-0.11586399,-0.027543996,-0.053527825,0.010053151,0.019063747,-0.05695614,0.0034946841,-0.06314408,-0.06451521,-0.04244684,0.024449233,-0.01464367,0.023739465,0.04283605,-0.001310846,-0.03293194,0.10150324,0.026096942,-3.688946e-08,0.053838063,-0.018882526,0.02775003,-0.026069991,0.012527384,0.029436838,-0.010687585,-0.08566651,0.017717667,-0.01669377,-0.027182888,0.16229016,0.049553864,0.0693616,0.026503282,0.014278147,-0.01635671,-0.0021095218,-0.048035342,-0.014063624,-0.11428293,0.060697824,0.020933302,-0.010197963,-0.031372603,-0.062433638,0.051489227,-0.00482744,0.004702596,0.005427689,0.0763568,0.02059448,-0.018518623,-0.003187232,0.09558123,0.03844113,0.083416834,-0.022006055,-0.07750854,0.101072416,-0.015482494,-0.081407554,-0.04717385,0.026311843,0.08247771,0.012033487,-0.07276994,0.0940628,-0.016457766,0.027667627,-0.0012833213,0.03380928,-0.023245055,-0.017706705,-0.008329635,-0.04485497,0.042635087,-0.10292924,-0.003553703,-0.061361693,0.043523416,-0.01221209,0.2080192,-0.018489687 +5.2.1.2,Also acts on maleylpyruvate.,384,0.99999994,0.007843315,-0.07599606,-0.04804664,0.09237408,-0.040230975,-0.005646379,0.003016248,-0.0032533803,-0.017161915,0.008257987,0.0020792335,0.020913327,-0.058867436,0.13962226,0.057661377,0.06644678,-0.05658595,0.02562411,0.073094495,0.017092088,0.06961848,0.07542944,-0.0052373493,-0.109776795,-0.071656644,-0.08058722,-0.0032580474,0.023678416,0.023179198,-0.033818975,-0.017164733,0.012658562,0.018457917,-0.07350635,0.031633608,0.09375878,-0.056484215,-0.00026785597,0.054646432,-0.0020788785,0.056638345,-0.05043963,-0.020767165,0.0011224843,-0.017488392,0.034568872,-0.0023559353,0.0061276495,0.039001387,0.05292492,-0.05068157,-0.072505996,0.0017441721,0.07740201,-0.028376184,-0.028388992,-0.06556536,-0.0031354548,-0.014281664,-0.016109586,-0.07275507,-0.012049743,0.0022418168,0.012597757,0.02351584,-0.00045831435,0.0014448725,-0.04467708,0.06046419,-0.012139988,0.06348805,-0.05426021,0.006701606,0.022072434,-0.03151685,-0.0058593,-0.033742804,-0.095402196,0.032224704,-0.011167439,-0.07437224,0.02227906,-0.002064649,0.05569538,0.026466936,-0.04247553,0.023617983,-0.08416755,-0.10857729,0.094999544,-0.04221166,-0.052060217,-0.009975459,-0.0044852057,-0.054225795,-0.013594006,-0.006955449,-0.021816242,-0.08312915,0.0042590303,-0.032913297,-0.014488944,-0.029110497,0.0009474114,-0.050268296,0.03864418,-0.005072597,-0.039386712,-0.052130334,-0.0048150965,-0.01636894,0.029181153,0.030369706,0.012683839,0.042759493,0.04679162,0.041347373,0.013719915,-0.04881444,0.01624005,-0.0010196643,-0.05373329,0.037476774,-0.010805975,-0.061359446,0.03982519,-0.043067932,-2.022074e-33,0.038588077,-0.033633053,0.0017962507,0.005246768,0.07231425,0.08357165,-0.023714377,-0.050287567,0.057611346,-0.09589847,0.011314507,-0.083660826,0.08143582,0.03823988,-0.1006758,-0.03798181,-0.01656287,-0.0038427834,0.05133266,-0.025581213,0.024172189,0.14629194,-0.009327804,-0.036346063,-0.038452324,-0.01608713,-0.029537456,0.021903422,0.0026324135,0.0025283573,0.022166608,-0.036431056,-0.025219781,0.039437074,-0.0046171215,0.10773737,-0.008551893,-0.035414025,-0.026249748,0.0908696,0.015546649,0.006515948,-0.12893327,-0.02931562,-0.00760015,-0.06864581,-0.020780029,0.07837038,-0.010545901,-0.014389295,0.07274842,0.013992618,0.082393415,-0.027304582,-0.041376837,0.047189772,0.0349036,-0.056544505,0.015201746,0.03877245,0.082963444,0.035404816,0.055828173,-0.006599929,-0.041499272,-0.016885892,-0.04572984,-0.06285741,-0.12064526,0.028466912,-0.0974177,-0.008134161,0.13131307,0.051012844,0.0019581285,-0.038824208,-0.068716645,0.03200482,0.015007124,-0.026071332,-0.04038193,-0.048794378,0.07255901,0.0054078246,-0.0018932229,-0.012336511,-0.023227667,-0.07118534,0.03179635,-0.016461594,0.07158009,-0.056645855,-0.019819185,0.015748814,0.0004870539,-2.7584272e-34,0.0016497439,-0.10019212,-0.01537671,0.012673514,0.009693644,0.037892804,-0.0074367817,0.06620803,-0.01001923,-0.0021508401,0.048443723,-0.04820427,-0.037182957,-0.006900138,0.066470936,0.034085426,0.08333084,0.08948601,-0.03926566,-0.014810561,-0.03148065,0.10701823,-0.019119091,0.009504721,0.04056269,0.05352364,-0.026701521,-0.05600452,0.015796414,0.09168101,0.024405427,0.028614575,-0.14648426,-0.07288516,0.052539293,0.037502706,-0.07379076,0.014799897,0.00904724,-0.010621634,0.06968394,0.003713196,0.10592447,0.14923672,0.0695028,0.034514077,-0.0143064605,0.04192064,-0.07748064,0.0076315613,-0.07951221,0.0034589856,-0.05144765,-0.034394287,0.03842294,0.020274373,0.044821333,-0.078297615,-0.046168596,0.034967475,-0.08787142,-0.0355948,-0.06577519,-0.025357123,0.060297996,0.046729825,-0.034840725,-0.028200753,0.12058687,0.014807655,0.12800884,-0.012676568,-0.025854988,0.022234866,-0.0608087,0.028955337,-0.01009684,-0.00408477,0.02688881,-0.036774993,-0.03705042,-0.059486844,0.0422003,-0.03438764,-0.06508161,-0.03673473,-0.036484227,0.055322498,-0.006156403,0.050384272,-0.014060712,-0.052298535,-0.08847163,-0.025028968,0.07991558,-1.7171768e-08,0.013980503,-0.066228054,0.04327028,-0.05704681,0.006336128,-0.022829654,0.037243422,0.033308186,0.07498807,-0.022620708,-0.030992035,0.035711013,0.13150944,-0.016875833,0.05811419,-0.0155229755,0.086378366,0.067161866,-0.077042826,-0.07844132,-0.10246241,-0.092377335,-0.0071725016,0.07695542,-0.046044488,-0.060252544,0.06679936,0.034684867,-0.025181983,-0.07973199,0.059809696,0.0069284826,-0.081910625,-0.0026490497,-0.003913086,0.051207874,0.09615539,-0.021952722,0.052281555,0.024041146,-0.015401316,-0.076266095,0.020201378,0.05530009,0.015720828,0.0015972555,-0.012818973,0.01743556,0.017598294,-7.811784e-05,0.030729527,0.05301383,0.018310348,0.011468978,-0.02487506,0.03583806,-0.022231193,0.0046466254,0.02514742,-0.03986868,0.037899468,0.016610349,0.13988942,-0.040099166 +5.2.1.3,Light shifts the reaction towards the cis-isomer.,384,1.0,-0.057690974,-0.030360453,0.01580274,0.11246354,0.037936006,-0.034673,0.01003784,0.02024746,0.0949324,0.0027467792,0.11754787,-0.017924735,-0.023018222,-0.035987876,0.038531862,0.038315475,-0.014368758,0.03416311,1.3908468e-05,-0.051871303,0.023946732,-0.11251949,-0.0063715354,-0.013440656,-0.0691284,0.019389367,0.0051003485,-0.00382782,0.02276832,-0.026800143,0.05235059,-0.025361542,-0.047020443,-0.03423471,-0.010199824,-0.022750942,0.021360828,-0.07424353,0.058246914,-0.0013967439,0.03512157,-0.03833463,0.006684102,-0.0029298689,-0.00068356196,0.000850466,0.029159728,-0.02308435,-0.040886186,-0.08620849,0.029958999,-0.013576522,-0.07221804,0.009999942,-0.035017613,0.065530494,0.0015992546,0.04673643,0.043342922,-0.07551051,0.038491692,0.008832695,-0.02101465,-0.030403864,0.031031862,-0.005343398,-0.009419265,-0.06265775,0.029455563,-0.04645157,-0.050679184,0.013506103,-0.06049371,-0.03160999,-0.01007328,-0.03983523,0.0052806986,0.0204522,0.03365356,0.023641918,0.051928308,0.035714958,0.0153984735,0.020666264,0.03877515,0.0117553575,0.0523073,0.016671045,-0.0655545,0.0008633813,-0.007938562,-0.0037145512,0.0016858849,-0.023037367,-0.020641087,-0.021658266,0.026337143,0.023881821,0.040442254,-0.00015506985,0.07026062,0.024411816,-0.18727651,-0.055161968,-0.075615585,0.0037264482,0.0025207538,0.11604674,-0.07629809,0.09566755,0.017757237,-0.015210596,0.0076395744,0.009647161,-0.022665605,0.058792673,-0.017555283,0.07080776,-0.03259815,0.017347964,-0.01553392,0.06731178,-0.055033114,0.053218696,-0.02447082,-0.009484191,0.031368382,-4.6700282e-33,0.043898813,0.041144807,-0.011398965,0.00964062,0.0031939463,-0.037894998,-0.022575455,-0.062666394,-0.11663631,-0.056325097,-0.035680447,-0.0111919325,0.0026313611,-0.017718067,-0.04291171,-0.049095903,-0.003199892,0.1215179,0.023143332,-0.037379153,-0.031350035,0.07369044,-0.0038347563,0.0019745925,-0.0144878365,0.09476775,-0.10207367,-0.0040947148,0.0032016453,-0.03462536,-0.025375105,0.07546266,-0.03558853,0.018322155,0.079142235,0.055934805,0.02229923,-0.006249812,-0.012067618,-0.0058769626,-0.044790037,0.026485024,-0.031931598,0.0024034982,0.12877506,0.04174144,-0.026390478,0.03227901,0.021490216,0.03427949,-0.031235293,-0.05592949,-0.019784942,0.008876726,0.03650198,0.021497712,0.07838317,-0.0143425325,-0.00046920168,-0.022255534,0.008975165,0.07164482,0.022994643,0.032954875,0.06491712,0.08853323,-0.1116721,0.0297595,-0.05459416,0.058775984,-0.097115956,0.02196984,0.061283156,-0.0032947804,0.058016177,0.060048856,-0.14579204,-0.017073503,-0.015432114,0.050286513,-0.077662036,0.010991441,-0.04346962,-0.09034605,-0.046200875,0.005420168,-0.058423698,0.061576176,-0.029741144,0.056069586,0.13836743,-0.014843251,0.016630651,0.007315474,-0.02235494,2.3685576e-33,0.044060573,-0.1093204,-0.0542911,-0.051700406,0.03242219,0.045430936,-0.012153928,-0.046568595,-0.0031817593,0.07773479,0.11100877,-0.039650723,-0.16701134,0.019657807,-0.07378937,-0.086493604,0.03181718,0.09744209,0.0011808544,0.041551385,-0.014065211,0.020524679,0.030052563,0.07137022,-0.0011781375,0.027542248,0.14436612,0.082179174,0.041173484,0.04687981,-0.04298701,-0.05304394,-0.03760438,-0.0024057063,0.04932048,0.08478338,-0.063692376,-0.002187424,-0.077003814,-0.0018091967,-0.02277183,-0.020591427,0.0154707385,0.018986117,0.0065678842,0.031923216,-0.020079013,-0.029022485,-0.07844179,-0.044037063,0.0034539346,-0.018426247,-0.0181154,0.0035217481,0.014582671,0.05247821,-0.080314174,0.018907767,-0.020044208,0.019864125,-0.014872898,0.009429177,0.029170234,-0.07053315,0.038827382,0.01047535,-0.0012427283,0.0055523748,0.0832915,-0.055097204,0.17822567,-0.014290888,0.03763024,-0.041656338,0.025932664,-0.119909264,-0.02088062,-0.027870338,-0.069486246,0.0329302,-0.07729881,-0.05026271,0.04263755,-0.030761477,-0.016384834,-0.010744641,-0.03754322,0.04518087,-0.014311566,-0.029806536,0.03316391,0.036662236,0.075778276,-0.06849681,0.08579204,-1.670769e-08,0.01945711,-0.026836129,0.04797825,0.031747267,-0.019799164,0.033509508,0.010488843,-0.035983983,-0.055123467,-0.014595038,-0.002252862,0.027136521,0.101715714,-0.009176995,0.0859174,0.015062105,-0.022882586,-0.020715194,0.029744288,-0.0059544356,-0.14817959,-0.056006134,0.02672239,-0.06967763,-0.028598735,0.004213426,0.056310605,0.05294716,0.020280523,-0.001834997,0.12678888,-0.049495813,0.026742905,0.049318016,-0.012746193,-0.059733056,-0.019287845,3.2499745e-05,0.05922489,-0.0081283925,-0.03547643,0.033362005,-0.101922214,0.06245321,0.016715555,0.112294026,0.0384618,-0.012539579,-0.12148502,0.0648194,-0.0035083871,0.009749233,-0.061843947,0.0035054768,-0.03782645,-0.02682402,0.013078513,0.065069936,-0.042662326,0.03499249,0.058798715,-0.043331373,0.052726682,0.0037849948 +5.2.1.6,Requires NADH.,384,1.0,-0.046406686,0.047333978,-0.027725693,-0.015828207,-0.04952215,0.020094866,-0.0002997106,-0.036367822,-0.0373193,0.010841179,-0.027059345,-0.0017107476,-0.032146603,0.09776542,0.05003825,0.008787619,0.05402171,-0.02340669,0.020446282,-0.022738187,0.044774026,0.0476053,0.052958596,-0.035042964,-0.01060582,-0.03658767,-0.036059376,0.013833811,0.05617001,-0.023935502,5.879026e-05,0.050378487,-0.06431565,-0.033158917,-0.0351871,0.07875038,-0.0052035484,0.056238513,-0.019424517,0.046967965,0.0072739297,-0.06955319,-0.058519397,0.025961138,-0.007471867,-0.059453867,0.0058261673,0.04840378,0.05318008,0.0011818211,-0.076770075,0.018182239,0.020105062,0.038977288,0.077064104,-0.05415702,0.06870011,0.004763829,-0.014644541,-0.055747904,-0.042011824,-0.011487696,-0.08568236,0.051153522,0.051725686,0.0037458136,0.03785405,-0.031971525,-0.04690696,0.08139566,-0.07948262,0.009742847,0.003466103,0.018137962,-0.061617516,0.011018447,-0.032108244,-0.065449715,0.1272158,0.022146761,-0.04290823,0.008447023,-0.05548482,0.05043293,0.10104735,0.08836432,-0.0055110753,-0.041171473,-0.08440033,-0.008468244,0.010273757,-0.10402008,-0.036633283,0.03422305,-0.084700584,-0.020852674,0.026175931,-0.018759694,-0.098013826,0.10851226,-0.07881601,0.03906253,0.01214027,0.025431745,-0.054022774,0.01796511,-0.009215941,0.02806892,-0.047313273,0.015987033,-0.016381435,-0.008120681,0.019245427,-0.022234585,-0.05066352,0.07813471,-0.018183066,-0.005316786,-0.05591671,-0.06261945,-0.019328753,0.015825437,0.011575593,0.052902717,0.0597238,-0.07086976,0.024251375,-5.6153464e-33,0.10526876,0.07097579,0.01467479,0.014527374,0.027515301,0.009895579,-0.06212167,0.02106748,-0.02103015,-0.038361,0.014258823,-0.06580472,0.015515963,-0.078464545,0.10456003,0.012374837,0.014469069,-0.020127898,-0.034341604,-0.03980385,0.029758256,0.017848995,-0.02492548,0.025609337,-0.030032258,-0.0088414075,0.029690666,0.0011089869,0.021478217,0.032563776,0.023488052,-0.04379142,-0.023628125,-0.028182024,-0.017194087,0.03810291,-0.11284699,-0.09469319,0.021855434,-0.01356761,-0.028945731,0.07302595,-0.016469786,-0.002979501,0.027910648,-0.08520133,0.08084616,0.06982647,-0.003288014,0.05018792,0.05047241,-0.010484606,0.04157157,-0.024117377,-0.0055906475,0.034575026,0.011092999,-0.071684,0.04924352,0.103141926,0.03863618,-0.07905656,-0.017778564,0.116556056,-0.088386886,-0.0058774548,-0.083749846,-0.014887111,-0.010565136,0.021696515,-0.026168039,0.0099340975,0.041362356,0.015383378,-0.0031749278,-0.033288665,0.062107924,-0.07058796,0.055692773,-0.047788315,0.0055869026,-0.08459609,-0.068470664,0.041315343,0.05237558,0.0072831223,0.07557417,-0.009871399,0.009830446,-0.029906562,0.009745654,-0.026200103,0.049991276,-0.119461805,-0.013729592,3.598465e-33,0.008030357,0.02499143,0.03950359,-0.04065731,0.09167039,0.063898824,0.025469786,-0.105563655,-0.031835336,-0.06709279,-0.01877718,0.06562728,0.04045157,0.005410992,0.059945162,0.0021332034,-0.021893263,-0.045747425,0.0018893083,-0.009544871,0.051614452,0.10945617,0.032222383,-0.016896171,0.024856905,-0.01200605,-0.066189595,0.06885266,-0.038736805,0.041076478,0.019809311,-0.017214354,-0.16585943,-0.03711823,-0.0016070998,0.028614683,0.0063764034,0.09422187,-0.103217825,0.053875253,-0.009387866,0.00097127183,-0.10749038,0.15481266,0.03216038,0.05328863,0.0059023965,-0.047496025,0.049047995,0.007953993,-0.019411162,0.026177993,-0.0034234812,-0.011760283,-0.040896993,0.0025976251,-0.08392721,0.022052495,0.04635907,-0.01140812,0.043831415,9.386772e-05,-0.05999679,-0.026389075,0.065404214,-0.08590256,-0.024313642,-0.016223777,0.07853944,-0.026045533,-0.011909111,0.07045284,0.050367672,-0.017233271,0.0041501373,0.0019139048,-0.08789337,0.05731563,-0.04332008,-0.050105024,-0.05656312,-0.008280128,-0.031836007,-0.026192969,0.037886143,-0.015136376,0.10555459,-0.13321005,-0.015020346,0.0053819576,-0.018429395,0.01931755,0.05384875,0.08136482,-0.013240607,-1.5176068e-08,0.002518448,0.0029708107,0.05058034,-0.040620595,0.0013580075,0.05028969,0.08440676,-0.031129532,-0.0037612745,0.053975333,0.07306323,0.12836547,0.102215156,0.1373369,0.028819567,-0.015912281,0.0006941164,0.00022751195,-0.12849973,-0.017233683,-0.11425015,-0.044086535,-0.039265443,0.09378307,-0.009172042,0.008075603,0.012548404,0.0017117279,0.006859447,0.034334034,0.06482208,0.029173646,0.05606913,-0.017664963,-0.050671924,0.04940768,-0.043550763,0.09797329,0.024922842,-0.041302726,-0.034200884,0.0449575,-0.013452914,0.060958505,-0.013239718,-0.028313672,-0.010999553,-0.072104014,-0.04010366,-0.024342472,0.06394822,0.0050938134,-0.009381153,-0.0026845676,0.04119979,0.033727054,-0.01801584,-0.026778534,-0.0080145905,-0.059099145,0.117237106,0.025435684,0.076486714,-0.096866645 +5.2.1.7,"Converts all-trans-retinol to 11-cis-retinol in the dark, thus reversing the effect of EC 5.2.1.3 retinal isomerase.",384,1.0,-0.02672231,-0.03089993,0.059556726,0.05386825,0.088249676,-0.03443921,0.0041493056,0.026032185,0.024152173,0.007543556,0.054866415,-0.04678434,-0.071789235,-0.01974862,-0.037192598,-0.04286617,0.00034795006,0.07858627,-0.077414006,-0.10765653,0.04890932,-0.04397902,0.030930154,-0.019618882,-0.032742243,-0.04130682,-0.006821551,-0.032570086,-0.0250157,-0.10478685,-0.04761855,-0.06939903,-0.039212395,-0.038904108,-0.039064344,-0.0025092163,-0.031690985,-0.08510775,-0.06684984,0.10245281,0.064340204,-0.03776313,-0.061003696,-0.026883394,0.074883886,-0.06899309,0.03040162,-0.0066328775,-0.026681302,-0.02234581,0.0025827321,-0.051226452,-0.12403206,-0.00022085261,-0.0043149753,0.07913843,-0.054943576,0.017649127,0.09010158,0.0069500217,0.06403468,-0.010306155,0.05455891,-0.030828083,0.00023294185,-0.010431716,0.060543958,-0.08115734,-0.002472224,0.010672995,-0.06213634,-0.048955396,-0.014519844,-0.027639069,-0.045512564,0.025118167,-0.03821259,-0.032575,0.029190058,0.036416665,0.07209241,0.009169108,-0.06748789,-0.0009266612,0.08979059,-0.0109953815,-0.022572184,-0.011860402,-0.018433155,0.061092228,0.016892465,-0.034585577,-0.0097724,0.018188205,-0.084706515,-0.025027443,-0.01569228,0.061736643,0.024706548,-0.055718474,-0.020947948,0.0018169464,-0.040193904,-0.06126237,-0.10147876,0.0016657353,0.06023542,0.04028801,-0.05056886,-0.023690712,-0.0034606387,0.0042461944,-0.014635786,0.004442355,0.00044252668,0.108698785,0.012436318,-0.0409424,0.10641545,0.06285181,-0.018144665,-0.0054523363,0.06371045,0.05977739,0.010380533,0.0441547,-0.019602157,6.308869e-34,-0.00014582943,0.060744755,0.008864002,0.083385676,-0.00036699322,0.08121498,-0.09442425,0.054029595,-0.0933854,-0.071774766,0.013927091,0.022000633,-0.0081008505,0.049320534,0.0061972365,-0.027507337,0.030492287,0.05172296,0.005584563,-0.104794554,-0.016798852,0.045570016,-0.08255366,-0.013406841,-0.04318599,0.05568238,-0.03194159,0.03939769,0.085455656,0.00843717,-0.018951023,0.056468353,0.015098549,-0.0057977443,0.018019717,0.09902399,0.09954906,0.031510264,0.018152839,-0.03228494,-0.023029417,0.062500514,-0.021517508,-0.07600935,0.069631405,0.015758067,-0.04007815,0.039465535,0.020919846,-0.0061551654,-0.023916237,-0.07333164,0.032354087,-0.06971883,0.011923763,-0.014740472,-0.066865146,0.036341853,0.0113777155,0.07110422,0.003359044,0.07091651,0.013332517,0.05490656,0.020003643,0.07614098,0.020239225,-0.025197256,-0.10209145,-0.029376911,-0.03862857,0.03935293,0.08285754,-0.0050647156,0.06816884,0.01480509,-0.06736424,0.036929134,0.02431855,0.012166805,-0.05752055,0.032687373,0.004579297,-0.008087268,0.016539052,0.0054427576,0.009673765,0.06054925,0.035693645,0.07478848,0.16621388,-0.08079399,-0.004579291,0.0625027,-0.018092515,-5.5750823e-34,0.0007184299,-0.09825404,-0.021351838,-0.038088933,-0.071250096,0.033775587,0.009958558,0.011171924,0.057632085,-0.0499861,0.097491495,-0.031159459,-0.030886339,-0.024923177,-0.01571877,-0.10487393,-0.013759742,0.035267036,-0.058287617,0.039219636,0.012970415,-0.063251406,0.06721787,0.02783874,0.02888924,0.07770333,0.067093514,0.09926008,-0.017567819,0.0069126533,-0.059872862,-0.04310072,-0.05072584,0.015860531,-0.045779143,0.033802178,-0.052548774,0.03451468,-0.024146412,-0.05116371,-0.0050425725,-0.012452772,0.02153306,-0.031782977,0.00036865543,0.10415415,0.02377817,0.037123848,0.006442009,0.001225497,0.01568792,-0.01100274,-0.081946746,0.011316408,-0.07156614,-0.0029306225,0.013638906,0.034510475,0.030149698,0.07594101,-0.038451407,-0.048208844,0.034181587,-0.064392716,0.024028454,0.029595448,0.016727092,0.10775254,0.060176507,-0.0054789274,0.15388179,-0.040212147,-0.02843424,0.01587976,-0.025619378,-0.08167724,0.015462851,0.014440817,-0.049874052,-0.018871684,-0.048676703,-0.120092854,-0.01471839,0.009661482,0.016232418,-0.034897048,0.013189265,0.03850501,0.057623494,0.05465308,-0.11932232,-0.044010475,-0.099678755,0.009270439,0.052464984,-2.9452789e-08,0.0069688256,-0.027249888,0.065672524,-0.0015601176,0.08780148,0.01862115,-0.018934654,0.07337393,0.037261687,-0.0033092792,-0.022011109,0.04217293,0.057784244,0.023945354,0.043979134,0.08061266,0.023891022,0.055393394,0.06627398,-0.001205218,-0.101873115,-0.047696136,0.02426641,-0.049640786,-0.022754073,-0.045561682,0.04002905,0.06680881,0.019679131,-0.07922734,0.105075404,5.203854e-05,0.07807813,0.07408727,-0.07243249,0.026690451,-0.023519281,0.07409923,-0.0680127,0.0790691,-0.06950293,-0.054668956,-0.05480352,0.020536626,-0.047603507,-0.042697135,0.08327664,-0.029573057,-0.023388261,-0.004883867,-0.0181453,-0.039424844,-0.020053994,-0.06397491,-0.08469861,-0.087778494,0.067851715,0.013837305,-0.020974882,0.028803209,0.06338035,-0.02487368,0.025890268,0.05197339 +5.2.1.8,"The first type of this enzyme found [1] proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.",384,1.0,-0.13258383,-0.012149851,-0.08723357,0.009471438,0.01451997,0.056885332,0.007677313,0.09257138,0.0958484,-0.080259636,0.0061729546,0.0105158035,0.017040161,0.13653871,-0.041001145,0.05940477,-0.06213096,0.017272256,0.032707047,-0.088066846,-0.030631837,-0.009562384,-0.051029302,0.04639639,0.054708518,-0.022216035,0.08808984,0.030935774,-0.042120893,0.042633638,-0.107277066,-0.030632574,0.029930351,0.001652386,0.055161767,0.078866735,0.018067576,-0.06745871,0.067479536,-0.025057586,0.01814316,0.009819157,0.034438916,0.0062726513,0.03241737,0.034122236,-0.00033780077,0.10723439,0.03582054,0.009730501,-0.0004461659,-0.024949977,0.0067427116,0.04639307,0.029141637,-0.016423844,-0.117810085,-0.011497501,-0.028846394,0.024722,0.008574044,0.042836003,0.02008658,0.053101793,-0.009280461,0.0059886593,-0.002687102,-0.036888447,-0.04260086,-0.045044944,-0.071636826,-0.0627587,0.008207547,0.09950998,0.007226196,0.0279385,-0.0007790968,-0.014968289,-0.022232722,-0.05349065,0.09219115,0.0055542295,-0.0022226898,0.1405215,-0.027355034,-0.015136781,0.040590532,-0.008356558,0.023873309,0.03788004,0.043491594,-0.06260621,-0.018940305,-0.05682254,-0.011899283,0.030298976,-0.022468036,-0.013142168,0.008656304,-0.00067311275,-0.025035322,0.015054216,0.008510178,-0.023796698,-0.04385817,-0.0011554838,-0.027504731,0.014185164,0.02232397,-0.07512525,-0.057373773,-0.01469065,0.047590848,-0.03179953,0.039010625,0.07010118,0.040637963,0.011859812,-0.0054526944,0.027338618,-0.04101331,-0.019935962,-0.016126258,0.0429085,-0.038553312,0.055521384,-0.15024284,3.236631e-33,0.062022373,-0.02491779,0.04158198,0.00562855,-0.0020621885,-0.031296883,-0.004223449,0.0054785428,-0.11945721,0.013328177,-0.09450197,-0.088609405,0.03971829,-0.029108653,-0.040163852,0.0022668163,0.021727065,0.033813234,-0.00032941933,-0.019647522,-0.013140367,0.09789774,-0.019668734,-0.031348303,0.047616217,0.12900987,-0.01640819,0.0041147526,0.03374573,-0.0020460791,-0.06906913,-0.049284212,-0.088887215,-0.029567154,0.0333241,-0.070940204,-0.016457288,-0.048367888,-0.012689307,-0.00407925,-0.043645434,0.016080447,-0.12614298,-0.019335695,0.039463714,-0.08996774,-0.0823821,0.02622306,0.0022320233,0.013800328,0.0617592,-0.03678269,-0.00052734383,-0.0603634,-0.07980412,0.0036946638,0.0029054,0.041118156,0.054505434,0.03157484,-0.0050639166,0.005991738,-0.10741473,-0.036753528,0.063458964,0.04594685,-0.08368156,-0.12863718,-0.09651812,0.0807504,-0.036774077,-0.010439357,-0.04090423,0.00025338697,0.07628025,-0.09250379,-0.035052337,0.001989882,0.003983251,0.026052354,-0.047487944,-0.034827,0.04672739,0.014207072,-0.07606081,0.020272722,0.035359673,-0.008967852,-0.0064127063,0.0504982,0.0610106,-0.0019560442,-0.004239905,0.009740033,0.037382234,-5.352837e-33,0.06855914,-0.08786895,-0.0042356085,-0.12800781,-0.029252304,0.087239034,0.01171993,-0.051269,0.043922406,0.042075176,0.07587015,-0.03408008,-0.041278265,-0.018831374,-0.026589202,0.040936798,0.015498485,0.033935793,-0.047709815,0.03588165,-0.0644963,0.026478997,0.074020356,0.04793349,-0.005230706,0.01995323,-0.029904328,0.13850977,-0.05120115,0.09136701,-0.117815666,0.009780984,-0.0116628,-0.04552926,-0.04048185,0.006663509,-0.0785042,-0.028514318,0.0098259365,-0.06323656,0.0035622031,0.0026619586,-0.0074354527,0.08945494,0.05242906,0.059560888,-0.0060321097,0.021828163,0.020314671,-0.020904787,-0.010366729,0.013694391,0.045650907,0.033267148,-0.0020393282,0.00836683,-0.007502716,0.022050915,0.056201335,0.0350968,-0.015132863,-0.06784431,-0.00149405,0.097858414,0.08795291,0.0571345,-0.010426205,0.022025203,0.023992555,-0.08657918,0.072998956,0.017899107,0.0178333,0.054302864,-0.01874724,-0.031848207,-0.04190504,0.039575078,0.037320208,0.024796577,-0.039364077,0.04602007,-0.056476947,-0.023786174,-0.014704296,-0.0516153,0.032577712,0.11164468,0.054064095,0.03394793,0.027391525,0.036507387,-0.04772673,0.0062415088,0.05360051,-4.634896e-08,0.04004432,-0.1006041,0.0008700734,-0.1223535,-0.055850517,0.020451155,0.0010169229,0.015337627,0.019403731,-0.031091716,0.048825942,0.10782048,0.026411122,0.03286207,0.017145593,-0.03739919,-0.02269043,-0.044718117,0.0027656069,0.055930756,0.009777759,0.0003273062,-0.07853332,-0.015303108,0.0705873,-0.07255625,0.01968736,0.038475916,-0.022040784,-0.021715153,-0.041281,-0.0055742445,-0.07465417,-0.06076415,-0.03407545,0.077310346,-0.041413303,-0.004448902,-0.034663923,0.02744436,-0.0097670015,-0.034017082,-0.09148175,-0.03609342,0.005028144,0.055666085,0.061811686,-0.06969081,-0.015103341,-0.038822778,0.0076641184,-0.04576946,0.021723818,-0.03815101,-0.09102683,-0.029703598,0.008843328,-0.08919426,-0.016569102,-0.09866428,-0.027881583,-0.011803663,0.17426986,0.03485447 +5.3.1.3,"Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+). The enzyme binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism [3]. The enzyme catalyses the aldose-ketose isomerization of several sugars. Most enzymes also catalyse the reaction of EC 5.3.1.25, L-fucose isomerase [3]. The enzyme from the bacterium Falsibacillus pallidus also converts D-altrose to D-psicose [4]. cf. EC 5.3.1.4, L-arabinose isomerase.",384,1.0,-0.07510195,-0.073296465,-0.017044064,0.008752112,0.00055106485,-0.014633303,-0.0621338,-0.040247,0.0662435,0.06777488,0.061576117,-0.06659442,-0.04993173,0.01192081,-0.020754963,-0.0053027566,-0.08984552,0.009927052,-0.06170987,-0.011847586,0.15628438,-5.7066376e-05,-0.036192678,-0.02850033,0.07895059,0.004081754,0.048816703,-0.04349294,-0.050066993,-0.09318726,-0.008380736,-0.116562776,0.08342707,-0.08169277,0.07037399,0.073089935,0.037400726,-0.010838483,0.10435065,-0.004562998,-0.0095235305,-0.044900037,0.048013046,-0.032160446,-0.05381915,-0.024862763,0.030548982,0.021430008,0.03548616,-0.029003773,-0.042317647,-0.09244129,-0.020394504,-0.03859766,0.021095606,0.013652813,0.02677857,0.00095347373,-0.008311238,-0.026675273,0.04455623,0.02455611,-0.036115065,-0.0031937729,-0.03480553,-0.08529524,0.054495994,-0.10020646,0.03744783,-0.052512396,-0.022372922,-0.074441314,-0.07986973,-0.0060886396,0.018672839,0.03116,-0.0024258876,-0.10222157,-0.0040206453,0.070013344,0.035587206,0.044713307,0.085109785,0.036307957,0.013140352,-0.029993074,0.018567149,-0.0061003226,0.04566508,-0.017700933,-0.028674768,-0.05470822,-0.004970643,-0.01210747,-0.0022460865,0.004266917,-0.026535917,0.08301566,0.04118903,0.011182472,-0.015335651,0.061227027,-0.102399796,-0.065992914,0.01172497,0.012845738,0.04795397,0.13167056,-0.0034562405,-0.008182445,0.008735426,0.017557966,0.057563152,0.06041979,-0.065464914,0.007384467,0.098637484,-0.082875125,-0.040607315,-0.017761955,0.030355852,-0.001012438,0.025499986,0.08899069,-0.015550023,0.08165689,-0.115563154,1.8228477e-33,0.052270282,0.018951239,0.026395125,-0.021504497,0.007667562,-0.020567056,-0.052232835,-0.014580167,-0.031255074,-0.008140963,-0.11552366,-0.035390943,0.033487044,0.06830267,-0.034186766,-0.009939325,0.0042799404,0.030375281,0.046893205,-0.02459883,-0.009528539,0.030564295,-0.01489029,-0.005476724,0.014021789,0.07781632,0.028844148,0.018854126,0.06758436,-0.016846774,0.029649278,-0.066635,-0.047505636,0.019993741,0.058524534,0.047994953,-0.03862197,0.037973475,-0.03678647,0.043818876,-0.0108055165,0.064734966,-0.059083756,-0.05292634,0.054876912,0.011942363,-0.06327346,0.058411535,0.03443805,0.059335314,0.040627792,0.0097449925,0.081344254,0.006203328,-0.05149509,0.012269654,0.005819041,-0.013692356,0.017185027,0.06562813,-0.029841712,0.08704416,0.039112575,0.030153617,0.022395305,0.00954056,-0.0036994987,-0.04938799,6.1292456e-05,0.08091337,-0.10402645,-0.0059203533,0.0147400675,0.01183131,-0.0071643326,-0.07599868,-0.10240612,-0.07637622,0.05204027,-0.03854131,0.012442382,-0.0049595507,0.02256892,-0.013356578,-0.050124045,-0.057797804,-0.0983158,-0.033721365,0.0006363913,0.08440748,-0.030084582,-0.04128573,-0.05880996,0.105373375,0.008161844,-3.255098e-33,0.098936856,-0.06726577,0.0861833,-0.10358062,-0.10923302,0.066901706,-0.0031580874,0.0013154227,0.03590515,-0.025221344,0.07573548,0.02563642,0.06176664,0.021331273,-0.015850471,-0.027777838,-0.045111783,0.033833798,-0.017872231,0.011572228,-0.0043912427,0.10161623,-0.01761606,0.011734156,0.0890633,-0.00010790097,0.0024116545,0.10345188,0.040500835,0.008986068,0.008778581,-0.033237446,-0.002859614,-0.074246064,-0.068872705,0.10781705,-0.053122837,0.02717428,0.041111,0.022719875,-0.045235127,0.022041267,0.056154456,0.012438828,0.026905235,0.027272489,-0.034758214,-0.03626181,-0.019701917,-0.06569323,0.018971346,-0.006156272,-0.023742381,-0.0028650777,0.022194376,0.0244553,0.010833206,0.059554644,-0.06254743,-0.034649123,-0.06905186,-0.062118053,0.11417085,-0.039464712,0.020522214,0.04174454,0.011233157,0.069584586,-0.023080176,0.0028492883,0.0949515,0.010317302,0.00770422,0.030168563,0.053462118,-0.08741271,-0.10600319,-0.020155814,-0.0111056855,-0.005835293,0.018363046,-0.012854296,-0.0057416405,-0.021496823,0.0010913302,-0.08933579,0.12286461,0.06840117,-0.005574103,0.044348553,-0.03624074,-0.03300733,0.014467349,0.031054158,0.083526194,-4.3839922e-08,0.025928624,-0.028986454,0.012810772,-0.024958573,-0.07244893,0.09354177,-0.0039832676,-0.014637368,0.026858574,-0.019861195,-0.00033722862,0.11983165,-0.0037015388,0.022620618,-0.008719525,-0.0094778715,-0.06326806,0.058245696,0.010455896,0.008362442,-0.093877606,-0.0012260749,-0.1069147,-0.02370706,0.030822631,-0.089453705,0.041527413,0.04462299,-0.042797256,0.0066197887,-0.012431197,0.05994403,-0.008827888,0.0012490994,-0.081577025,-0.0009165671,-0.09991214,-0.019226855,-0.025083262,-0.0036343522,0.01941289,-0.007285342,-0.07741548,-0.0011134188,-0.01382723,0.0347562,-0.0078016976,0.06341111,-0.042956077,0.057517216,0.10087843,-0.050122447,-0.0013023127,-0.06807121,-0.07961121,0.049369596,-0.032552693,-0.043600455,-0.022613024,0.037460204,0.07627238,-0.03303696,0.12708957,-0.07086155 +5.3.1.4,"Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+) [2]. The enzyme binds beta-L-arabinopyranose [4] and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism [6]. The enzyme can also convert alpha-D-galactose to D-tagatose with lower efficiency [5].",384,1.0,0.0020832352,-0.06287288,-0.058723815,0.056991555,0.032536905,-0.045591198,-0.0064827707,0.034862284,0.04249735,0.05389574,0.009760198,0.01449526,-0.06770616,0.053743083,-0.007283356,0.01323398,-0.03542054,0.09532541,-0.018073756,0.019860005,0.106494434,-0.04385369,-0.017443612,0.008397507,0.04268552,-0.013921457,0.06352462,-0.057013646,-0.0606709,-0.07597236,0.008881434,-0.06144807,0.10231137,-0.04473108,0.026663654,0.07308074,0.04856792,-0.021859793,0.04051576,-0.02391266,0.057832975,0.03145129,0.078464895,0.0048818025,-0.053055707,-0.0361591,-0.035441153,0.04385616,0.051779304,-0.0023457115,-0.027651949,-0.08458573,-0.024190266,-0.02518717,-0.0016029093,0.05264836,0.008345219,-0.06377945,0.010113175,-0.009741006,0.07369061,0.041228164,0.01126552,0.041311555,-0.018696785,-0.08641476,0.054353736,-0.043036774,0.00396047,-0.043363154,0.023563161,-0.05507582,-0.0635376,-0.04142215,0.014729727,-0.0026104914,0.009308038,-0.082387485,0.042180482,0.031474713,0.02613887,-0.008175445,0.051235896,0.021087252,-0.014805097,0.02437661,0.056135755,-0.012924212,0.03619639,0.027482364,0.0092667155,-0.008428343,-0.031052073,-0.0649084,-0.035179503,-0.022436924,-0.0062365965,0.030053,0.018504253,0.019892244,0.0061430302,0.04847235,-0.06439347,-0.06601628,-0.0015782597,-0.0039374926,0.058171377,0.1093332,-0.018664295,-0.0118645765,0.049573503,-0.0029750543,0.077424645,0.06418658,-0.048281215,0.04588197,0.05730867,-0.079048924,-0.017368574,0.026719477,0.04350112,-0.021290533,-0.018569814,0.02091273,-0.047967594,0.12294046,-0.07806984,1.3805758e-33,0.07518163,0.0635544,0.026518336,-0.041380562,-0.034193538,0.0142548345,-0.109790854,-0.07094642,-0.08058312,0.020991506,-0.07066355,-0.065843344,0.052938003,0.056382637,0.018703258,-0.023671994,0.003347626,0.0247106,0.08153133,0.013116647,-0.019393252,0.029898021,-0.03422388,-0.021946073,0.059266005,0.065034464,-0.014068037,0.013561924,0.13630003,0.007821762,0.018747047,-0.014073034,-0.07899896,0.0549765,0.021726351,0.010774783,-0.07679906,-0.01910402,-0.00675289,-0.034820832,-0.0019638385,-0.008673145,-0.06521071,-0.010343788,0.08703229,-0.022358445,-0.02212804,0.077996105,0.018394414,0.056497425,0.019157188,0.0075480295,0.05018436,-0.017063927,-0.046696503,0.035771716,-0.0046170508,-0.016582165,0.02419059,0.0613948,-0.02976955,0.045484327,-0.0011320559,0.022829952,0.056350727,0.0075763157,0.045397416,-0.058015525,-0.0622138,0.03349563,-0.07238704,-0.10259945,0.030860215,0.044233423,-0.03733503,-0.020495618,-0.0819863,-0.09438876,0.10232339,-0.06705123,-0.05694007,0.013654544,-0.04355915,-0.008453406,-0.03943934,-0.012071341,-0.070056394,-0.023659423,-0.0013899474,0.045223206,0.026326936,-0.018130338,-0.063723914,0.07435432,0.029326169,-3.0504189e-33,0.073584974,-0.08125981,0.040883575,-0.0670966,-0.0908259,-0.0054451544,0.0069442675,-0.032665912,0.07080051,-0.01624221,0.049235463,-0.044264186,-0.06066242,-0.04163717,0.018805798,-0.031130034,0.029822659,0.048075043,-0.01878267,-0.013330924,0.046172105,0.08195439,0.02854984,0.06290897,0.068046376,-0.039201777,0.02525831,0.10035359,0.03876821,0.0072206594,-0.009344083,-0.015276449,0.008581664,-0.08545337,-0.08202032,0.0900192,-0.050111324,0.0047005992,0.07786927,0.0265555,-0.08505759,0.044735722,0.027720239,0.05849719,0.06021038,0.062232792,-0.035864078,0.016329104,0.040224873,-0.065974,-0.020023441,-0.062657036,-0.033592176,-0.0150285,-0.031175505,0.028457474,0.008579996,0.057327583,-0.044551894,-0.06100902,0.007005331,-0.04551335,0.12162516,-0.06783988,-0.0021490597,0.008348947,-0.006738097,0.04886475,-0.03498053,0.0039080796,0.043399945,0.0146825705,-0.01088729,0.090860255,0.040911727,-0.07796673,-0.09037927,-0.10155576,-0.011412789,-0.051722977,0.015670639,0.062396906,-0.035973463,-0.024675207,0.05170776,-0.10570221,0.083461784,0.09559478,-0.02216427,0.068286516,-0.04552664,-0.044838786,0.015441083,0.036807038,0.056870826,-4.5025022e-08,0.036603145,-0.07798958,0.028528418,-0.11796287,-0.060498696,0.033949602,9.681072e-05,-0.023240091,0.037284184,-0.056986082,-0.025340827,0.14272855,-0.03564693,0.06089867,0.029971875,0.04104968,-0.018391024,0.0035339056,-0.04286482,0.0011240647,-0.069305375,-0.007743738,-0.14582784,-0.021127027,-0.0026831815,-0.063130684,0.01245231,0.041817345,-0.05129273,0.03581098,0.045002345,0.043887503,-0.028245179,-0.0007468812,-0.06315597,0.051918294,-0.0776713,-0.04120431,0.01855396,-0.032506462,0.026288906,-0.023308044,-0.05104802,-0.0009907619,-0.06627617,-0.043911558,-0.04535288,0.090037726,-0.02871314,0.05007024,0.07241493,-0.1094319,-0.07425034,-0.083656035,-0.028463265,0.012147712,-0.00051494275,-0.04386354,0.007725874,0.010535649,0.057420056,-0.05744567,0.14440954,-0.1000527 +5.3.1.5,"Contains two divalent metal ions, preferably magnesium, located at different metal-binding sites within the active site. The enzyme catalyses the interconversion of aldose and ketose sugars with broad substrate specificity. The enzyme binds the closed form of its sugar substrate (in the case of xylose and glucose, only the alpha anomer [4]) and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. Isomerization proceeds via a hydride-shift mechanism.",384,0.99999994,-0.046622004,-0.042350594,-0.062812865,0.039128862,0.022172146,-0.050944004,0.048561983,-0.0649515,-0.01527322,-0.022590393,0.081605755,0.0012712805,0.0032915664,-0.03617234,-0.0064012874,-0.005584663,-0.0925419,0.012759337,0.0018427013,-0.016744671,0.12515166,-0.01926185,-0.013430744,0.031380452,0.019286564,0.06049754,0.06759277,-0.04658226,-0.00017958232,-0.08144931,-0.045862082,-0.042637497,0.05034555,-0.036338933,-0.00886373,0.14311793,-0.041251186,-0.024174003,-0.029361298,-0.022867946,0.04155499,-0.07238665,0.062450446,-0.013458648,-0.0724946,-0.07845409,0.045073148,0.0063032955,0.006543969,0.024911538,-0.0318109,-0.08258489,-0.018838473,-0.0133077325,0.010978345,0.03226064,-0.03734525,0.022907183,-0.005970573,0.005560513,0.080316134,0.06171478,-0.05166938,0.036331423,-0.00034102565,-0.0675585,0.0676794,-0.0795447,-0.0015739604,-0.10187403,0.014118135,-0.08613434,-0.10709141,-0.08197607,0.031651136,0.006454878,0.043837413,-0.07936311,0.033068236,0.032322258,0.031093355,0.052967954,0.09905794,0.07723309,0.013048626,0.0036893839,0.03345686,-0.011718797,-0.0052545583,-0.015535646,0.049421407,0.016104942,-0.045925964,-0.0037099707,-0.046280246,0.0038874848,0.028617924,0.04968015,0.070396625,0.043977145,0.022903817,0.05234748,-0.00786803,0.033098485,-0.021646095,0.040386084,-0.017398711,0.09181722,-0.015207611,0.04679097,0.031686556,-1.6083697e-05,0.050896533,0.036252663,-0.034205835,0.086096615,-0.007952132,-0.009239718,-0.008289228,-0.01852313,-0.01636654,0.026410954,0.014354901,0.062156472,0.030410334,0.04253811,-0.14688303,1.8034629e-33,0.05037143,-0.010974487,0.06009521,-0.012142993,-0.054722235,-0.024691643,-0.04528961,0.02787663,-0.059942514,0.029839026,-0.05608295,-0.0030322988,0.037590314,0.028060185,-0.023403563,-0.115239896,-0.0023344336,0.038093187,0.07179708,0.06820993,-0.084614396,0.09475537,-0.047812898,-0.0023438148,0.02090451,0.06890299,-0.013864592,-0.06489908,0.01243679,-0.011151691,0.029815221,-0.036630325,-0.07170076,0.037397943,0.06668687,0.008866006,0.0047374866,0.017840791,-0.05840032,0.0065288097,-0.040299427,-0.0005245309,-0.0280167,-0.057150457,0.04937193,-0.022446448,-0.05481175,0.07437586,0.020283848,0.050898474,0.05969044,0.0085271085,0.055236526,0.056468703,-0.065604515,0.07774682,-0.04694952,-0.039264534,0.028257802,0.029397272,0.016168047,0.04590878,-0.002257199,0.02202387,0.056756977,0.04297484,-0.014773063,-0.08258194,0.00035266424,0.12052497,-0.117199525,0.014978921,0.06754336,0.048174866,-0.02185376,0.0074211354,-0.10869346,-0.03458857,0.08784134,-0.019790858,0.0064651812,0.003670032,0.04051624,0.007512325,-0.124791324,-0.051439986,-0.033611238,-0.032969683,-0.014965727,0.032997105,-0.03323569,-0.001069777,-0.021404058,0.013963168,0.024494102,-3.708149e-33,0.11260856,-0.11940191,0.10471608,-0.07836526,-0.088081196,0.0093984185,0.05460213,-0.078949355,0.018236523,0.031462688,0.095099166,0.048150193,0.018548122,-0.09086189,0.037908085,0.008662811,-0.026105307,0.12778525,-0.041839294,-0.006879586,-0.011427659,0.08919774,-0.008420882,-0.014973766,0.01479468,-0.04890632,0.025081603,0.047133848,0.07714586,0.024172192,-0.04754671,-0.04819329,0.015894214,-0.08113788,-0.059883896,0.10562927,-0.09549359,0.011571593,0.023896815,0.02290469,-0.013680943,0.025314936,0.016107002,0.058108523,0.0642449,0.06859836,-0.052886598,0.063441746,-0.014973391,-0.07491679,0.033065133,0.004652781,-0.02455849,-0.0293465,-0.002824636,0.08674368,-0.003744067,-0.0057194326,-0.0014398294,-0.014769512,-0.021762239,-0.024327127,0.08336456,-0.032558825,-0.008078773,-0.043007467,0.02764507,-0.036623467,-0.022566313,0.026483024,0.073107466,-0.040245127,0.046055328,0.03877189,0.04942096,-0.0428868,-0.04186631,-0.08457242,-0.05540502,-0.071689986,0.04523519,0.025698097,0.028598202,-0.039110314,0.036898375,-0.03130975,0.07388727,0.06790131,0.056266986,0.0055253897,-0.030185197,0.0044945846,-0.001729129,-0.006803525,0.02789931,-4.1269352e-08,0.0016378247,-0.070944324,0.024900569,-0.06252104,-0.065614656,0.10905602,0.04608638,-0.034263995,0.041889474,-0.025034215,0.018817907,0.10176447,-0.052590515,-0.01922688,-0.023617622,-0.009766202,-0.049377978,0.021948816,-0.05186496,-0.008549539,-0.106980525,-0.04457514,-0.09161631,-0.03925177,-0.02807052,-0.11131177,0.024484623,0.07572257,-0.05233223,0.0031606276,0.014728146,0.06509928,0.02383356,0.011586574,-0.026530862,-0.004588859,-0.04866545,-0.005137485,-0.013034543,-0.0570352,-0.059403684,-0.12090864,-0.002329699,-0.0165504,-0.022006005,0.036823,-0.021602888,0.049259234,-0.009431615,0.09446097,0.016443731,-0.002168857,-0.03814059,-0.07265074,0.0020471234,-0.0018457159,0.0125472965,-0.021950707,0.0148455305,-0.0600363,0.02057662,-0.029859712,0.13431521,-0.09778537 +5.3.1.6,Also acts on D-ribose 5-diphosphate and D-ribose 5-triphosphate.,384,1.0,-0.052523967,-0.09385873,0.055785965,-0.04031007,0.04551493,-0.009620164,0.049226433,0.01688484,0.056839146,0.07967296,0.0007564788,0.04231119,-0.04218955,0.05310553,-0.024740312,0.00304381,-0.022270635,0.030826904,0.020266274,-0.011417965,0.12891832,0.056171298,-0.011406284,-0.05727156,-0.0031168205,0.030545982,0.053553656,0.017883893,0.00514234,-0.104781225,-0.05620372,0.007573248,-0.008013392,-0.049735587,-0.008183807,0.11140198,-0.026469145,-0.01912459,0.014028177,0.053855557,0.07617599,-0.051449914,0.061761405,-0.017872185,-0.022121914,0.011921378,-0.06486019,0.064959206,0.0278693,0.009274555,-0.028290492,-0.06963902,-0.03887198,-0.020163057,0.02761148,-0.0035119627,-0.04386714,0.011164657,-0.008564356,-0.04327948,-0.0223042,-0.0061190035,-0.04387273,0.004964234,0.095124386,-0.0413586,0.017637681,0.006350335,0.005574726,-0.00029670048,-0.055436056,-0.022966934,-0.0010859027,-0.00691518,-0.01563639,0.023917375,-0.011058017,-0.074341565,0.043548543,-0.10342204,-0.020915879,0.028395755,0.03583706,0.0113174375,-0.0067742253,0.07024419,-0.05459332,-0.0038165185,-0.013584697,-0.018210404,0.020743394,-0.016401716,-0.0049287756,-0.03020302,-0.10298971,0.02079479,-0.01395052,0.050559565,-0.05756087,-0.035511564,0.010491992,0.058108654,-0.07381719,-0.09640412,-0.020357605,0.024631985,-0.038706373,0.03524008,-0.020041907,-0.028328901,-0.039330166,0.01686894,0.02182623,0.032060128,-0.043039184,0.066970944,0.019035086,-0.0558655,-0.028235704,-0.0791268,0.016510183,-0.056067135,0.0002026908,0.097345404,-0.09277766,0.04446778,-0.063925125,-2.5992487e-34,0.080969125,-0.015768686,0.038796533,0.02625919,-0.03676104,0.004896607,-0.09042799,-0.030527707,-0.055053364,0.040980306,-0.08026602,-0.073531054,0.12074243,-0.022332828,-0.020460643,-0.016126718,-0.037340537,0.038125116,0.056647003,-0.022854464,0.02251556,0.14511958,-0.060298856,0.03719718,0.0193594,0.03745637,-0.015396213,-0.025401363,0.062257886,-0.033227783,0.054188363,-0.031135302,-0.047384106,0.023202531,0.0670669,0.021983683,-0.027682984,0.0055388506,0.008054366,0.00012796317,0.049429305,-0.056127056,-0.0587984,0.02052581,0.05466744,-0.07182539,-0.04468507,0.027102776,0.00055152265,0.021721609,0.09871942,-0.04259405,0.12282553,-0.04706629,-0.05445425,0.04893046,-0.024675526,-0.03953591,0.029315336,0.08931228,0.0121342465,-0.0025650277,-0.053530566,0.002876969,0.049638595,0.055163812,-0.04091472,-0.10538016,0.02871832,0.074384786,-0.022012182,-0.041417122,0.1112502,0.017588325,-0.023202516,0.00883789,-0.06377091,-0.0010764602,-0.023449397,0.06485036,0.016310744,-0.1142694,-0.019815214,-0.04642039,-0.033510555,0.04745058,0.027970374,-0.1614415,-0.01167756,0.023865819,0.09643041,-0.08690496,-0.05732027,-0.021549243,0.008882965,-1.4016759e-33,0.040945843,-0.0622134,-0.014906452,0.0040468774,-0.08732081,-0.006073463,0.053435102,-0.08196594,0.016205752,-0.03870412,0.08019991,0.016037479,-0.042167436,-0.025192766,-0.06273161,0.11233184,-0.017758446,0.06896904,0.0032004344,0.013188305,-0.02243071,0.09775489,0.039722286,0.119006105,0.052929785,0.058731932,0.041152917,-0.0201269,0.025945632,0.035728093,0.024511503,-0.00018900099,-0.044045147,-0.048862305,-0.05568183,0.023700796,-0.05880399,0.014767413,-0.0141707165,0.0035608804,-0.048597742,0.06257646,0.100730665,0.06530904,0.01115577,0.055174153,-0.0057092793,0.0027505627,-0.111267895,-0.024834987,0.006439884,-0.019004947,0.0052026217,0.04795614,0.03576666,0.06469039,0.06243088,0.032203417,-0.02259206,0.015260879,-0.008248817,-0.028906545,0.013115831,-0.08800301,0.10393527,0.06629566,-0.009021309,0.016546572,0.050913464,-0.03473508,0.036092162,0.023547899,0.030865902,-0.028443836,-0.019902779,-0.04348498,-0.03631909,0.0055219075,-0.041214194,0.010220927,-0.08190893,0.05118872,-0.051085077,-0.040987108,-0.042116318,-0.096536525,-0.0068170056,0.1267069,0.044688325,0.06511544,-0.06982733,0.000318981,0.034111064,0.046471924,0.09873215,-2.3317194e-08,0.05776131,0.004840819,0.029553425,-0.090453655,-0.025266618,-0.015295975,0.059436016,0.047982693,0.035566192,-0.015943807,-0.031413667,0.089945816,0.05954613,-0.01374436,0.1192612,0.0046598865,-0.046451446,0.013375652,-0.07604467,-0.05133416,-0.014722471,-0.021089362,-0.064070955,0.07850473,-0.038070478,-0.055872954,0.06929736,0.0013470877,0.065492734,-0.02131803,0.017224863,0.037026923,0.0033149181,-0.10563116,-0.017498547,0.09412256,-0.005149267,0.0073059453,-0.013927561,0.06407889,-0.07048686,-0.07548231,-0.054491933,0.03996809,-0.07211993,-0.009475937,-0.010494538,0.05755285,0.028868577,0.015551948,-0.004623026,0.041820914,-0.032481074,-0.065887295,-0.10904496,0.015669242,-0.032337323,-0.053779397,0.09032729,-0.015430279,0.00451438,0.010431232,0.095643446,-0.04979595 +5.3.1.7,Also acts on D-lyxose and D-rhamnose.,384,1.0,-0.02827501,-0.1107965,0.020296786,-0.04188064,0.037351627,0.041216422,0.027874107,0.00879385,0.0011499561,0.020876588,-0.00058832276,0.05128951,-0.08549033,0.06819405,0.032326177,0.06714717,-0.02340291,0.043189507,-0.020764843,0.022709252,0.06967703,-0.010066376,0.06624134,0.034338556,-0.016386464,-0.008863464,0.010572973,0.037741978,0.024744384,-0.124409676,0.010177867,0.0061198804,-0.0037283276,-0.0228215,-0.096885055,0.0799345,-0.044874478,0.0169181,-0.0029047276,0.032184217,0.035642214,-0.02213798,0.062583074,-0.021016968,-0.0997285,-0.035615176,-0.14975579,0.03489404,-0.00866864,0.058236483,0.00054605823,-0.1240807,0.011145402,0.07095319,-0.019815017,0.038601864,-0.10587164,0.04099665,0.048717726,-0.035294767,0.01964085,0.06302379,-0.027508086,0.07277562,-0.058812216,0.007951463,0.004964335,0.00051681953,-0.007860124,-0.016868513,0.03732322,-0.07485307,0.0031947356,-0.048351955,0.008920797,0.034461588,-0.005062603,-0.08286899,-0.078628294,-0.045760095,0.022327876,0.04507634,-0.0069412845,0.020177038,0.034729566,0.03930889,-0.031096006,-0.063271195,-0.05534163,-0.015317523,0.022362685,-0.058930986,-0.06687134,0.008145117,-0.03157518,-0.023532288,0.034178615,0.07219322,-0.023475256,0.011936671,-0.05353381,0.008301233,-0.04339583,-0.03523879,-0.0615364,-0.024248976,-0.0309958,-0.04116301,-0.04797834,-0.05821188,-0.015247211,-0.027011883,0.032388408,0.025358219,-0.085518226,-0.010110354,-0.049304605,0.029484622,-0.047007352,-0.042972784,0.04927006,-0.019451175,0.019205967,0.0026754169,0.024241084,0.05836319,-0.06776723,-5.3894432e-34,0.061146487,-0.037455563,-0.057847578,-0.0038008294,0.03436836,-0.041732885,-0.082091846,0.016431805,-0.010021246,0.029157013,-0.0891402,-0.023875093,-0.010791384,0.00862373,-0.054303944,0.038212862,0.0860237,0.004188521,-0.052632917,-0.031522654,0.041976605,0.16679263,-0.08312338,0.0139305135,-0.012018983,0.0630004,0.04993449,0.040892396,0.052135915,0.018161247,0.018721974,-0.056286767,0.0030020606,0.072203904,-0.0082063265,0.15055934,-0.11824491,-0.06556134,-0.05515567,-0.034717925,0.067897625,-0.0023646927,-0.09595098,-0.02967463,-0.06808543,-0.025065655,-0.026925677,0.0153584415,0.05614574,0.047414217,0.112201534,0.03276912,0.046427075,-0.017386278,-0.026554836,0.0058217426,-0.044486664,0.005627376,0.08639966,0.07480508,-0.014781478,0.00737301,0.02504336,-0.06392277,0.021082068,-0.006498938,0.0035887714,-0.06623458,-0.04431414,-0.020058831,-0.04131651,-0.057295647,0.13159938,-0.028294597,0.06507379,-0.07003013,-0.010777176,-0.070404924,0.019829284,0.029874032,-0.049557548,-0.04926194,-0.010906863,0.0057020513,0.03524593,-0.06101679,-0.0010057235,-0.09245369,-0.038667124,0.024651991,-0.04832823,-0.06841138,-0.021727016,-0.001442467,-0.004276595,-1.5619243e-33,-0.05318608,-0.015010118,0.06727094,0.06881618,0.016519219,0.07914309,0.025244808,0.05240985,0.012438244,-0.022630896,0.070420444,0.016159013,-0.11829195,0.00420961,0.044967495,0.027997358,0.023959063,0.044330627,-0.01937021,0.0002500338,-0.025298027,0.07274837,0.012773998,0.06896409,0.040689256,0.038106948,0.0718455,0.028868893,-0.0135586625,0.017149935,0.03485057,0.015803106,-0.07611751,-0.061975703,-0.06522742,0.12212029,-0.051770408,0.047839835,-0.07742598,-0.02715301,0.013729058,-0.052536134,0.07033241,0.14682482,0.0135727,0.016106984,-0.0165646,0.050730374,-0.036984604,0.010371194,-0.0390435,0.02882846,0.0070352787,0.012295447,0.048326228,0.08202051,0.0043992167,-0.052119147,-0.0008868992,-0.003499226,0.00088886195,-0.029460013,-0.081710994,-0.008503928,0.049076304,0.035288032,-0.06026787,0.032847323,0.052433,0.021421067,0.084195204,0.01006249,-0.026461976,-0.01936166,-0.10212864,-0.13360912,-0.07426797,-0.13428187,0.008021377,-0.0142975,0.005340617,-0.032165676,0.0201149,0.07229456,-0.0062255836,0.017035179,-0.02463136,0.022870112,-0.037460588,0.041498452,0.013431935,0.038478494,0.00027687883,0.023580033,0.063098654,-2.2328006e-08,0.066517346,-0.009631317,0.050343867,-0.0218987,0.0474289,-0.044630773,0.011470154,0.06823808,-0.056483883,0.09120711,0.022570137,0.047808796,0.012454687,-0.060679805,0.12196287,0.0037503035,0.030823467,0.12486818,-0.10333483,0.057641968,-0.03215954,-0.009116705,0.035188846,-0.040551174,-0.045065057,-0.014669956,0.09155291,0.013369974,0.025410317,0.031601433,0.05824027,0.012087902,-0.014165337,0.01167854,-0.04076224,-0.026483234,-0.012622577,-0.008431879,-0.0071858955,-0.019362055,-0.006273762,-0.022314785,0.040339403,0.1048405,-0.11004214,-0.033652917,0.0062338845,-0.020432247,0.03264157,0.013256897,0.025715075,-0.04372267,-0.022250533,-0.047630835,-0.09792379,0.026683165,-0.0015664633,0.054982815,0.0105476575,-0.057708737,0.01988436,-0.01965253,0.11181884,-0.013646642 +5.3.1.8,A zinc protein.,384,1.0,-0.12467595,0.025850765,-0.026786214,0.059562493,0.015050227,-0.02124223,0.12540461,0.07272162,-0.010812788,-0.012606519,0.0045478223,0.0054381075,0.033869263,0.03307399,-0.06651066,-0.019676907,0.013948141,0.03134287,-0.062700644,-0.017955704,0.020106794,0.08426097,0.03057429,0.0016438981,-0.013869681,0.00079459354,-0.0051306253,0.01574668,0.0068944637,-0.028436618,-0.042887498,0.00483216,0.0191881,-0.011099018,0.022156075,0.018185727,0.0012631018,-0.020823969,-0.013147519,-0.03266288,0.102844596,0.07342305,0.034631006,-0.06295799,0.0054530217,0.0510574,0.038605597,0.031970453,0.03747087,0.041713428,-0.07819401,-0.10615024,-0.011505441,0.027159141,-0.0053595863,0.04362087,-0.12562251,-0.00057126995,-0.030203087,-0.013210745,0.009450327,-0.05317699,-0.020485578,0.012976267,0.14468507,-0.05592207,-0.041035317,0.006164966,0.011227793,-0.03450456,0.024532057,0.007952878,-0.008382775,0.07475749,-0.052025612,0.030846143,0.0432658,-0.10542584,0.061063766,0.027711375,0.0029699139,0.03730051,0.019752156,0.124425225,0.087463394,0.05177837,0.0019930254,0.042478062,-0.10320827,0.013013921,0.030219289,0.04012713,-0.012006723,0.038807485,-0.107745335,0.04853043,-0.015189648,-0.03175617,-0.038244072,0.08872644,0.043378424,0.04011644,0.12467882,-0.109445296,-0.003992656,0.00792702,0.019407408,0.06223587,-0.0022011434,0.063297585,-0.00021000658,-0.033328157,-0.014651774,-0.032438457,-0.0044745402,0.015965167,0.03299027,0.023935191,-0.07303296,-0.01823556,-0.016462846,0.0027802563,-0.014823773,0.009209791,-0.03954584,0.049818538,-0.08640412,-6.178346e-33,-0.022339378,0.0093322415,0.05207562,0.06263815,-0.010735223,0.062982954,-0.019876715,0.0295576,0.013785575,-0.019643195,-0.090126865,-0.041639086,0.03778682,0.005283306,-0.053368803,-0.08200438,-0.0017827979,-0.008814338,0.0559602,0.027289435,0.0038811015,0.06960435,-0.019186972,-0.02543062,0.04128427,-0.041649252,-0.034479957,-0.09405994,-0.037255023,-0.020062804,0.01761464,-0.014720558,-0.06321148,-0.052471023,0.12565356,-0.055618763,0.015404348,-0.072514884,-0.0084448885,-0.057627745,0.01114224,-0.040796317,-0.07625274,0.059511043,0.045074753,-0.035358913,-0.048562054,0.050771322,-0.035207987,-0.06926266,0.10260566,0.028706895,0.057663232,-0.043986887,-0.15977608,0.010682518,-0.016740162,0.02882804,0.027099596,0.07518202,-0.0027239101,0.059536472,-0.100494854,0.10977446,-0.014454878,-0.023579663,-0.11794768,-0.061020482,-0.019636525,0.062711105,-0.018110208,-0.08500652,0.10662411,-0.03269461,-0.029263116,-0.019938482,-0.048916727,-0.0025970032,0.05405402,0.008526948,-0.043849483,-0.06507929,-0.04699146,0.038287446,-0.08399396,-0.0094598215,0.027059378,-0.04323229,0.06866281,-0.027981889,0.04252537,-0.052328374,-0.04205801,-0.028995898,-0.058934122,3.3259062e-33,0.011612056,-0.028700586,0.03561228,0.05470079,0.06600291,-0.04080428,0.029458912,-0.024972769,-0.006682171,-0.029323917,0.1396707,-0.034244318,0.08525433,-0.017982202,0.052566037,0.1320031,-0.08235848,0.08797338,0.08080386,-0.0006049598,-0.055769593,0.028083045,0.050460245,0.0745343,-0.027295828,0.075363286,0.003352439,-0.020509465,0.019340055,0.11122118,-0.0408302,-0.00450672,-0.0056508733,-0.1184825,-0.086705655,0.02524986,0.040509846,-0.1338376,-0.015933119,-0.0604212,0.013075183,-0.005732319,0.00097399496,0.1330067,0.08554549,0.03634841,-0.023237474,0.009959381,-0.06872534,0.030549485,0.06282219,0.03481389,-0.010266152,-0.016668916,0.006052041,-0.0054421127,-0.041218348,-0.0140673565,0.009054316,0.03346418,-0.0040788082,-0.049629178,-0.0101351,0.05439391,0.011469873,0.012147948,0.038828127,0.015558506,-0.0063508046,-0.015203104,0.11870609,0.12197497,0.046631597,-0.02578315,0.00868547,0.03761304,-0.010448811,0.007815829,-0.04128995,0.01511476,-0.085063696,0.006125652,-0.008302071,0.0190037,0.033811282,-0.041098934,0.02052897,0.05442398,-0.06939051,0.008292109,-0.07607402,-0.049962617,-0.09461364,0.07382137,-0.0132074375,-1.27913875e-08,0.03163894,-0.043743722,0.0051473677,-0.103852905,-0.012388889,0.03662954,0.015895156,-0.06452868,0.014331981,0.0075718593,0.03434095,0.07281979,-0.014425895,0.047184087,0.013364358,0.010512846,-0.060961213,0.012261681,-0.041623726,0.007466441,0.012369865,0.057610787,-0.009865185,0.035989996,8.974402e-05,-0.08408858,-0.032213427,0.07805231,-0.019605577,-0.03388538,0.022475537,0.014725953,0.022645308,-0.00560845,-0.037965003,0.011744247,-0.00013795681,-0.053942937,-0.047880925,-0.026994877,-0.075751245,0.015457872,-0.018300742,-0.014543113,-0.028402423,-0.105669245,-0.007263818,0.032025527,0.0061864844,0.029075196,0.008456221,-0.010745634,-0.013386123,-0.037111294,0.0069923513,-0.030415187,-0.026670175,-0.060231484,-0.0576915,-0.0101970965,-0.03485245,-0.034712203,0.096453086,0.0047023008 +5.3.1.9,The enzyme from yeast catalyses the reversible conversion specifically between the alpha-D-glucose 6-phosphate and beta-D-fructofuranose 6-phosphate. The enzyme also catalyses the anomerization of both D-hexose 6-phosphates [7].,384,0.99999994,-0.05008766,-0.022602364,-0.04610004,-0.010650153,-0.00074590463,0.008110838,-0.036601994,-0.0062965425,0.003011954,0.09692167,-0.07036048,0.08487249,-0.13898446,-0.03340843,-0.059751958,-0.031781144,-0.095701426,0.120944686,-0.013279772,0.011992548,0.11132495,-0.012553008,0.010433319,-0.027767977,0.117693834,0.009901758,0.05251919,0.004930758,-0.0008565364,-0.09168191,-0.024323415,-0.018436037,-0.013358993,-0.022674004,0.018458692,0.088154554,0.07015297,-0.020939022,0.010293702,0.011438148,0.029461905,-0.019603834,0.020948539,-0.02819747,-0.06139393,0.0044838027,-0.078934565,0.07054133,0.07274321,-0.029166602,-0.026094915,-0.03910071,-0.12697369,-0.0027968553,-0.033034198,0.07419529,0.004503351,0.010967484,0.019984271,0.03125152,-0.05094463,0.0044521536,0.02222465,0.07757141,0.0492945,-0.10229658,-0.003205065,-0.026723495,-0.05294522,0.0059616826,-0.05068176,-0.047592897,-0.016254663,-0.05553214,0.08303093,0.011994049,-0.06108708,-0.036500063,0.015638767,0.03231934,0.08290347,0.0192641,0.080273814,0.066224754,0.01701033,-0.047546394,0.0105141075,0.043254018,0.118607245,0.05430664,-0.009635344,0.020037126,0.010875088,-0.046577904,-0.049296334,0.023590911,0.0071227076,0.07615334,0.083293326,-0.019348405,0.029298745,0.067065075,0.03575643,-0.039736472,-0.004448554,0.062162567,-0.08560422,0.11257384,-0.001806761,0.009912718,-0.018664258,0.022701966,0.06804141,0.03464477,-0.022283405,0.031551152,-0.063182235,-0.07211272,-0.022425199,-0.02666125,-0.009088787,0.018679094,0.04562506,0.07095233,-0.04522412,0.035888936,-0.04215021,-3.9039196e-34,-0.004972761,0.056438513,-0.0025258183,-0.030060468,-0.060214784,0.015180518,-0.05195782,-0.0012715312,-0.10004459,0.030585457,-0.05619347,0.0039404393,0.008547795,0.0310792,0.0045974567,-0.037467804,0.07577459,0.06184848,0.0068867486,-0.018520357,0.08570828,0.055158697,-0.05725264,-0.006138121,0.044518866,0.050378665,-0.05608981,0.09410445,0.0023603535,-0.03722606,-0.007981891,-0.06520255,-0.021331437,0.014949003,0.038619842,-0.023058778,-0.038649406,-0.0299075,-0.009792775,0.023172982,0.041002322,-0.014372755,-0.04529049,0.010713317,-0.0061438866,0.01888239,0.039772216,0.015676904,0.03701556,0.042591926,-0.0163984,0.008525174,0.047575567,0.025365824,-0.045900475,0.0047085173,-0.0027639365,-0.02530724,0.03585455,0.010506343,-0.05424102,0.034028176,-0.011138176,0.032811724,-0.007031534,-0.07705114,0.017749596,-0.04985072,-0.06422247,0.09194886,-0.09528847,-0.029725684,0.020810671,-0.028395524,0.043715786,-0.06577046,-0.02356558,-0.04228456,-0.036603313,-0.036796257,-0.004632047,-0.0007650822,-0.0771823,-0.06882691,-0.06828509,-0.014354547,-0.025613762,-0.10498631,-0.04167004,0.009686547,0.03994332,-0.10386947,-0.06050596,0.04360904,0.057691768,-2.0626212e-33,0.086536676,-0.044137873,0.08795694,-0.037145123,-0.11128561,0.05993758,0.11228857,-0.05134492,0.013750295,-0.059154015,-0.012441004,-0.03607969,0.04784833,-0.09867295,-0.0038108646,0.010529174,0.0027529707,0.087990746,0.011717193,0.015533376,-0.027283931,0.11538987,-0.061555408,0.038314607,0.04385974,-0.0005980273,0.06471846,0.09901747,0.08736071,0.0060298587,0.01985503,-0.041548956,0.036207505,-0.012731515,-0.09374406,0.06316942,-0.07130439,0.0100075705,-0.009170338,0.04932482,0.064656384,0.05978975,0.00096803345,-0.0006392124,0.008679852,0.055370178,-0.05022304,0.06259773,0.051326707,-0.057765096,0.049540963,0.0400542,-0.020710843,0.03681801,0.01857415,0.010720218,0.058913317,-0.03551233,-0.0012895192,-0.011776609,-0.0045834878,-0.08985615,0.09322308,-0.04854162,0.036026087,0.048131473,-0.011865479,-0.0043775793,-0.015064961,0.02796687,0.03554992,0.019220717,-0.0050731283,0.016452178,0.035475902,-0.057362612,-0.07636398,-0.018874586,-0.00664795,-0.028170401,-0.018582147,0.03550844,-0.0105782235,-0.0028803523,-0.015305862,-0.09545508,0.062568374,0.06032851,-0.014617917,0.07445196,0.015372485,-0.03460241,0.019071542,0.03953444,0.10446207,-3.170511e-08,0.05010259,-0.080290966,0.050317984,-0.0593287,0.0026274314,0.0056204754,0.035987705,0.014512616,0.0038132472,-0.020627499,-0.055183973,0.07186102,0.051500987,0.013450137,0.021943236,0.016886013,-0.08275261,-0.005378033,-0.034684047,0.0032051094,-0.045752764,-0.034578808,-0.12861544,0.04134314,0.020916939,-0.0077549783,0.029035104,0.039284304,-0.025575336,0.0036481514,-0.052080188,0.01379481,0.0051461677,-0.045756094,-0.04695341,0.028863583,-0.021472473,-0.051904995,-0.02059699,-0.0063341507,0.034359355,-0.043146875,-0.043916382,0.04379119,-0.13349237,-0.007350936,0.019301325,0.0387129,-0.015937863,0.04786004,0.06164843,-0.0029102454,-0.11055488,-0.15301402,-0.055034615,-0.0014949002,-0.04478766,-0.022918139,-0.05336294,-0.003950473,0.0370754,-0.038783114,0.17772003,-0.12765212 +5.3.1.12,Also converts D-galacturonate to D-tagaturonate.,384,1.0,-0.031043716,-0.07228831,-0.026395395,-0.026297236,-0.048709255,-0.0950391,0.03519425,0.042033743,0.019433526,0.016018942,0.021798553,0.008672374,-0.0940434,-0.009221758,-0.048828162,0.024122437,-0.020274993,0.11650888,-0.0069936025,0.045677345,0.115073204,0.012084634,0.05412397,0.036078773,0.10088602,0.02322509,-0.022511598,-0.04518366,0.0146042,-0.06114594,0.012073647,0.04177573,-0.038454864,0.0059658242,-0.06373279,0.051473275,-0.003383297,0.0048452313,0.0016819296,-0.028321113,0.065604664,0.017202398,0.064410105,0.029875366,-0.0070182662,0.050771948,-0.10269984,0.059561353,-0.046352807,0.0021274786,0.0026241525,-0.06270397,-0.053172648,0.01981833,0.025031518,0.17585199,-0.041760154,-0.058960974,0.037404165,0.032933805,-0.014672583,0.07473516,0.0045774993,0.04826704,0.03711733,-0.05424056,0.00011698844,-0.01867828,-0.013043694,-0.016166583,0.013268619,-0.06667081,-0.014021839,-0.02752389,0.05197814,0.0054893526,0.027107764,-0.055842426,0.12089814,-0.046945173,0.04191648,0.07599319,0.009110754,0.043619312,0.03148621,0.026537275,0.027266959,-0.026200408,-0.050914515,-0.028199807,-0.02330344,-0.09756216,-0.09499491,-0.01963995,-0.1390555,-0.042628895,0.021037072,0.016852798,0.031202696,0.036890738,-0.005927394,-0.0052826656,-0.024526237,-0.100012384,-0.08042633,-0.038892027,0.02369397,0.036676012,0.0032393555,-0.048104577,0.011792819,-0.038962223,0.011935482,0.031036949,-0.06042731,0.056395687,0.0017732255,-0.0010735834,0.032398663,0.021384973,-0.0359357,-0.021911709,0.0005966322,-0.0005517826,-0.05101181,0.031183608,-0.056541238,8.45399e-34,0.042712357,0.0066665756,0.04350352,-0.030391105,-0.05211483,0.027874611,-0.12471162,-0.056165844,0.02722969,-0.03047036,-0.08316594,-0.063440196,-0.023633417,0.10408513,0.006649525,-0.0034706679,0.009628965,-0.022266608,-0.025173483,-0.08148106,0.02568325,0.13402627,-0.072806634,0.009456428,0.0598185,0.046907645,0.008995647,0.042322528,0.10757168,0.04177002,-0.037711162,-0.023716388,-0.021203978,0.010104929,-0.017141579,0.09782833,-0.016882807,-0.09575609,0.010327635,-0.037384406,0.0034489958,-0.043306638,-0.034142084,-0.03176994,-0.015507,0.03601589,0.012517615,0.020502668,0.023607656,-0.041000694,0.026625715,-0.007654517,0.023252277,-0.05634996,-0.059111007,0.034516145,-0.008918784,0.011662303,0.10686283,0.07747095,-0.076197766,0.0060012164,0.0044888468,-0.0055878703,0.039351244,0.025237244,0.01706011,-0.035026245,-0.04725443,-0.032366507,-0.0921485,-0.06680193,0.014645605,0.021389551,-0.032902423,-0.027871223,0.00021700951,-0.055582657,0.013039018,-0.06497777,-0.069565155,0.0048336075,-0.047064245,0.019650977,0.055994995,-0.024627792,-0.02398764,-0.08783386,0.023262216,0.059540927,0.0028923939,0.0032402824,-0.04631831,-0.045077782,-0.05294677,-2.557299e-33,-0.0847895,-0.036237586,0.0018948922,0.090623155,-0.02437149,0.05187487,0.016467363,0.031367585,0.035325132,-0.07396873,0.025086906,0.02016242,-0.1091821,-0.07109455,0.060214736,0.0027720486,-0.029503247,0.07991573,-0.04753413,0.061388016,0.06896935,0.09714309,-0.05774651,0.067273006,0.033938464,-0.011569786,-0.022318585,0.06101554,0.063075736,0.012080187,0.027073147,-0.055130657,-0.079085305,-0.027907744,-0.07903914,0.024200162,0.04663571,0.00079336413,-0.0951641,0.028165773,-0.06565816,0.025592558,0.089933395,0.08042646,0.04448236,0.05107956,0.015416643,0.00011230147,0.041679606,0.025292406,0.033384535,-0.07517686,-0.012076738,-0.0075810133,-0.076993346,-0.009300516,0.108418845,-0.032862924,-0.05118887,-0.030483278,-0.045883954,-0.10246226,0.107471064,-0.10680838,0.037049327,-0.008684805,-0.018943058,0.08483415,0.011671742,-0.013519326,0.15581588,0.07422216,-0.0030966278,0.03531402,-0.024335673,-0.07023683,-0.039835677,-0.031703573,0.048294418,-0.07298018,0.038935192,0.02148447,0.05366919,0.05682187,0.044563495,-0.03735391,0.060974646,0.057316657,-0.03449063,0.046401236,-0.062490936,0.055341475,0.020148993,0.057217885,0.008111054,-1.8922895e-08,0.023511995,0.0048312484,-0.013327284,-0.047194753,-0.0037547285,-0.05916906,0.0361552,0.015199382,-0.03083095,-0.0747813,-0.027655842,0.10713007,0.009017833,-0.010362841,0.064746976,0.05475066,0.04837387,0.089924075,-0.07396846,0.0038710528,-0.04472326,-0.002041966,-0.027285518,0.0030013828,-0.031000255,-0.02906303,0.052875444,0.096281886,0.052855536,-0.03388486,0.054760206,0.034150466,-0.023069177,-0.006023353,-0.037373096,0.043885883,-0.026031008,-0.044414304,0.06286368,0.048578676,-0.011481736,-0.024188241,0.023311429,0.060577005,-0.088965654,-0.06852701,0.004348925,0.02262086,-0.038858145,0.066150434,0.027582139,-0.008530979,-0.0725375,-0.10310642,-0.09213402,0.0057199053,-0.0030157662,-0.00015132371,0.010866616,-0.04701153,0.058870304,-0.0030642187,0.08305501,0.024952527 +5.3.1.13,"The enzyme is involved in the pathway for synthesis of 3-deoxy-D-manno-octulosonate (Kdo), a component of bacterial lipopolysaccharides and plant call walls.",384,1.0,-0.046409357,-0.06643493,-0.0529805,-0.06135314,-0.022723313,0.060141444,-0.08706224,0.0035017685,0.016367119,0.098498836,0.06550952,-0.11358953,-0.060876504,-0.014924358,-0.0034122672,0.047822323,-0.09881968,0.06902329,0.0006954492,0.06884274,0.074933745,0.056246527,-0.032729052,-0.034846682,0.06342144,0.11006194,0.046008095,-0.021828657,-0.04626816,-0.05615378,-0.042990383,0.004119737,0.10169872,-0.090443216,0.11496866,0.07998353,0.009882291,-0.031624176,0.09218477,0.0061760615,-0.03702339,-0.03781196,0.0015329499,-0.05721954,-0.030074105,0.04369616,-0.017206723,0.052106544,0.09943177,-0.09362472,0.016170705,-0.030881803,-0.048702598,0.04939076,0.021384476,0.037355285,0.018302364,0.062053658,-0.017029135,0.038820334,0.003947318,0.015474298,0.039801933,0.041955136,0.0030264123,-0.07075079,-0.03475244,-0.004238037,0.030209394,-0.027299656,0.017003126,-0.07652797,0.019662473,-0.014492989,0.026489235,0.06525568,0.019599829,-0.086681776,0.050054904,-0.048868366,0.07838098,-0.014243321,-0.0046201055,0.04256068,-0.05496002,-0.01827152,0.013414647,-0.062323324,0.05988989,0.036468763,0.029752357,-0.017284775,-0.040072605,-0.06916928,-0.041191775,0.041161414,0.02655023,0.025557958,0.034093726,-0.022958735,-0.009679861,0.024092816,-0.00893323,-0.09106474,0.0033182648,0.0017162504,-0.020145688,-0.024464069,0.0077695823,0.009230058,-0.0114513105,-0.035864234,0.0019949367,-0.026080996,-0.07925528,0.035195813,0.10142221,-0.10425516,-0.069886036,-0.038569003,0.007969354,-0.06907773,0.0029439288,0.033284727,-0.0846186,0.040032826,-0.0044032065,-2.203399e-33,0.04837134,0.008755634,-0.011237526,-0.050552566,0.06820425,-0.10339504,-0.071729325,-0.008135267,-0.07334737,-0.029889395,-0.10260324,-0.11290212,0.011229051,0.07783483,-0.022196611,0.06083378,-0.07832527,0.0018808792,0.047861975,0.049414072,0.047087856,0.011508967,-0.027520237,0.06759135,0.03332029,0.06563757,0.036659725,-0.05145274,0.012115693,-0.026052874,0.025795382,-0.037163485,-0.043501858,-0.0057077967,0.025625046,0.023310633,-0.06256595,-0.055492315,-0.044218887,0.036639187,-0.008583176,0.007987347,-0.043965586,-0.054974135,0.0011581571,0.053739503,-0.047820386,0.013285584,0.057554793,0.024551196,0.08183546,0.02283661,0.027579874,0.08107086,0.011008802,-0.0017592813,-0.014380846,-0.029868765,0.08249245,-0.014775816,-0.025683848,0.05233524,-0.028003149,0.05941895,-0.0041212514,-0.018827327,-0.08916588,0.006810856,0.062399082,-0.0032180508,-0.07557879,-0.062700614,-0.0032500816,-0.00938652,0.04366312,-0.013448236,-0.073407166,0.011207184,0.045297697,0.0045881947,0.093670346,0.03306831,-0.008634442,-0.06265288,-0.03268245,0.017735658,-0.074841924,0.010544762,-0.072493926,0.021358468,0.04297322,-0.05032793,-0.06937201,0.031424444,-0.04428415,-2.239847e-33,0.062184088,-0.10047091,0.07232604,-0.070197284,-0.027508933,0.07560991,-0.01730384,0.02639603,0.0927277,-0.007505372,0.044726033,0.01300588,0.07992089,0.045040175,0.04590499,0.038744643,-0.025311345,0.066607766,-0.07284351,-0.015347044,0.031854033,0.022141263,-0.019547952,0.034795173,0.028063014,-0.04575206,-0.05286918,0.046105858,0.012735921,0.07227765,-0.0050578844,-0.042229522,-0.0473269,0.04897651,0.02114469,0.055629518,-0.044458732,0.033825804,-0.022586895,0.038300596,-0.05616557,0.027857495,0.038093746,-0.008130572,-0.019268991,0.016676936,-0.0738644,0.041570965,-0.01818535,-0.021267131,0.02362936,0.01959615,-0.034895033,0.018362591,0.030953709,0.041906845,-0.015615903,0.047639728,-0.02099803,-0.01663289,-0.07712363,-0.1265328,0.07857344,-0.009227863,0.028453097,0.15756853,-0.034573946,0.0059465896,-0.003400271,-0.07745486,0.017254008,0.057960514,-0.002044422,0.07430621,0.0036186497,-0.082292415,-0.11696856,-0.023952495,-0.032287657,0.028493142,-0.011616673,-0.038364008,0.010391206,0.035483155,0.0051682442,-0.060386453,0.034450524,0.079596855,-0.0144436415,0.01776076,-0.037114456,0.013948213,-0.080527835,0.039010182,0.10221408,-3.3023124e-08,-0.007178265,-0.09422774,0.077649735,-0.10056659,0.009445509,8.4893756e-05,0.056791455,0.032241922,0.06097348,-0.087531775,0.06609438,0.12798226,-0.020338757,0.03667133,0.014794828,-0.022940807,-0.07245122,0.027166173,-0.024920534,-0.0135550145,-0.06936673,-0.029507302,-0.06270248,0.026539387,0.025090916,-0.0115715135,0.026868386,0.029917596,-0.03965233,0.007862535,0.060198925,0.04236925,-0.056641698,-0.028026653,-0.08429769,-0.016304174,-0.010249142,-0.07109776,-0.057469297,0.01586976,0.008706417,-0.03941663,-0.052584473,-0.01268842,-0.009604871,0.05220953,-0.04541607,0.09793338,-0.027031558,0.014431149,-0.0011202457,0.02402307,-0.035540815,-0.054775573,-0.08610326,-0.02132121,-0.03464765,-0.050384745,0.019502858,-0.007400409,-0.040120117,0.0036103951,0.19842318,-0.012845518 +5.3.1.14,"Contains two divalent metal ions located at different metal-binding sites within the active site. The enzyme binds the closed ring form of the substrate and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. Isomerization proceeds via a hydride-shift mechanism. While the enzyme from the bacterium Escherichia coli is specific for L-rhamnose, the enzyme from the bacterium Pseudomonas stutzeri has broad substrate specificity and catalyses the interconversion of L-mannose and L-fructose, L-lyxose and L-xylulose, D-ribose and D-ribulose, and D-allose and D-psicose [2].",384,1.0,-0.011109192,-0.09784377,-0.07798394,0.015706673,0.08281925,0.050034404,-0.08647073,0.036268666,-0.0030012373,-0.017301636,0.05546022,-0.025432121,-0.010726613,0.0057040765,0.0017253929,-0.041182917,-0.097606376,-0.0019397846,-0.029634286,0.029287552,0.14928307,0.047232192,-0.060993873,-0.011851048,0.010091323,0.036727846,0.09838473,-0.043514196,-0.006784877,-0.045244437,-0.019635279,-0.056283306,0.06470667,-0.06346183,0.025329178,0.0683277,-0.0005553795,-0.0003064138,0.08048014,-0.012056321,-0.013474214,-0.017761817,0.08131092,-0.07527325,-0.06429852,-0.073433384,-0.005828032,0.07927796,0.017773386,0.008401984,-0.02852966,-0.061671786,0.01458672,0.039905697,-0.024783622,0.079638675,-0.0016284302,-0.02420598,0.009163497,-0.008703202,0.04333661,0.03975293,0.017732933,0.032263044,-0.027272291,-0.10957786,0.07087866,-0.037772354,0.027999813,-0.054504406,-0.023037575,-0.04020029,-0.062077403,-0.031501688,0.07273428,0.0023696034,0.043144748,-0.08574948,0.020718783,0.011413778,0.015471896,0.017585598,0.068041936,0.021342605,-0.023585748,-0.010763605,0.009928207,0.0012829576,0.052796938,0.007948502,0.043884095,-0.02723018,-0.037642416,-0.09261836,-0.07842508,0.012270033,0.028012447,0.061060425,0.06185235,-0.031844497,0.0028739066,0.057771403,-0.026288169,-0.074264675,0.004296919,0.017882928,-0.022998452,0.109776504,-0.014323999,-0.045716163,0.09824795,0.020657897,0.026949702,-0.024124682,-0.08120488,0.024321184,0.05803378,-0.07996719,-0.12052793,-0.03874164,0.0002969875,-0.014007828,0.007597605,0.04114957,0.021390833,-0.0023106846,-0.13247809,1.8938378e-33,0.03255596,-0.027773913,-0.008938977,-0.039862614,0.013203344,-0.05098251,-0.07097151,0.0020044816,-0.0855375,0.055694308,-0.046543404,-0.018668154,0.017703796,-0.0047527864,-0.014418356,0.009336609,0.008676062,0.0161604,0.017144172,0.029774379,-0.0032361536,0.059830435,-0.0054024956,0.008168369,0.06107154,0.07690297,0.0737442,-0.04772962,0.005515159,-0.023402063,0.04870284,-0.02481139,-0.08637849,0.01272591,0.11117927,0.01176323,-0.017945163,-0.01969221,-0.007840191,-0.019288812,0.034787416,0.02705636,-0.049546614,-0.005893839,0.07398591,-0.04227117,-0.036676805,0.07724541,0.003714808,0.1154934,0.050004575,0.0029106103,0.074529834,0.002339102,-0.073081456,-0.009230694,-0.047571734,-0.0014464726,0.08507494,0.045754768,-0.02455414,0.028510787,-0.06542621,0.042998865,0.02260531,0.0014291508,0.01667384,-0.07313859,0.049230456,0.096392296,-0.09813459,-0.01778591,0.0626705,0.031317044,0.024505509,-0.033714686,-0.13508591,-0.027229963,0.13865116,-0.0020809092,-0.007888056,0.06536961,0.011323537,-0.017578073,-0.058641624,-0.10160217,-0.072988175,-0.030777048,-0.038249917,0.022997826,0.013335972,-0.04087874,-0.00836871,0.05917263,0.0075466186,-4.0493988e-33,0.0752513,-0.12244493,0.09408387,-0.05718686,-0.056239296,0.011460276,0.003874879,0.024171086,-0.0061208783,-0.046774067,0.0937757,0.039358437,-0.03729385,0.008209275,0.037345428,0.020667385,0.0159323,0.075078845,-0.014472454,-0.008201494,0.012032403,0.032124117,0.0005278002,0.012407243,0.05504529,-0.04003201,-0.02650484,0.08690815,0.033989705,0.08633297,-5.3937132e-05,-0.003161736,-0.0056359535,-0.1014008,-0.056926176,0.09056677,-0.07317491,0.07099398,0.0658819,0.03450822,0.016892016,-0.0033550626,-0.060264196,0.0297999,0.0044334373,0.07562466,-0.09643789,-0.02224722,-0.016599018,-0.06407304,0.0018898734,-0.010804788,0.02833344,-0.045726757,0.007885919,0.072676405,-0.049709905,0.0034920166,-0.00020741369,-0.029878339,-0.024054531,-0.07186291,0.01129468,0.01659305,0.011959741,0.02528297,0.0669727,0.008846767,0.0092271855,-0.067797735,0.0748638,0.033087514,0.061694276,0.026379671,-0.0055389176,-0.11568266,-0.04591793,-0.10948932,-0.019160554,0.040799644,0.07662987,-0.015393144,0.008522007,-0.037021674,0.07421094,-0.041867044,0.0689423,0.08397612,-0.013976741,0.02707519,-0.024675133,-0.009011093,0.0055020247,-0.007559485,0.0907187,-4.6984262e-08,0.028965887,-0.04131598,0.04223968,-0.070824616,-0.02038182,0.07640008,0.0020194952,-0.040116202,-0.03254722,-0.006241159,0.012084832,0.09584448,-0.06004658,-0.026440369,0.055962134,0.0060047265,-0.112270765,0.017525267,-0.05123714,0.044264,-0.041016914,-0.008854711,-0.11105344,-0.008619467,-0.004561925,-0.046324193,0.05226187,0.014219616,-0.051355585,-0.012952095,-0.010032849,0.058229588,0.0021525463,0.10419777,-0.08433907,-0.079430655,-0.04601593,0.0063740336,-0.03901673,-0.038301103,0.0026006144,-0.0152389165,-0.07578154,0.00087757077,-0.014117468,0.014872337,-0.02428922,0.08278791,-0.00082541583,0.0023387691,0.06279054,-0.052472707,-0.015051117,-0.07957482,-0.060065046,0.004817777,0.010629487,-0.018940544,-0.039868552,0.004311534,0.017780613,-0.010235228,0.15789333,-0.06870074 +5.3.1.16,Involved in histidine biosynthesis.,384,1.0,-0.0019787513,0.04102024,-0.15989561,-0.051919077,-0.0010785343,0.049394995,-0.012409848,0.06103054,-0.013659477,0.018180959,0.011886611,-0.029157182,-0.013797789,0.030757375,-0.0540156,-0.036209818,-0.12174634,-0.00916737,-0.06569075,-0.099043235,0.006478212,0.05843998,-0.034224972,-0.04180331,-0.018377176,0.0017969796,0.022624906,-0.03456344,0.009554908,0.0017999613,-0.021544512,-0.089035496,0.11672749,-0.08278319,0.10385085,0.06511858,-0.03883699,-0.0032085145,0.09620681,0.08650229,0.01909148,0.014676521,-0.052084725,0.031990115,0.037137944,0.0029606284,-0.005052777,-0.013115709,-0.0017178975,0.07972139,-0.041364964,0.03635747,0.0035820429,-0.065213874,0.040939797,0.005695836,-0.05258427,-0.020983702,-0.042191215,-0.037461996,0.025107315,-0.06522112,0.02278623,0.006405823,0.036773503,-0.043261543,0.101183936,-0.04616589,0.05351775,-0.049456395,0.009094063,-0.06486973,-0.0100949975,0.11801767,-0.0014406206,-0.06581038,-0.04475224,0.003611142,-0.0034749943,0.040614054,-0.018453473,-0.056715768,-0.037771888,0.064060874,0.021591235,0.033341207,-0.008365991,-0.025106516,0.05155449,0.085409366,0.01751985,-0.099612966,-0.038000774,-0.07593919,-0.042627778,0.00040086647,0.03402132,0.00627197,-0.025245829,-0.055128943,0.055264127,0.013253352,-0.14735591,-0.00591316,-0.018078465,0.013576487,0.014632675,0.07190624,-0.08022192,0.054760676,0.028505642,0.026804011,-0.0007183359,-0.020468814,0.015657218,0.13997601,0.03758045,-0.03367166,-0.023958316,0.008788411,0.020201834,0.01589222,0.028618274,0.13194104,-0.059644032,-0.055662457,-0.039438985,-2.5384172e-33,0.051930945,0.051667318,-0.050207693,0.025847431,0.013575078,0.049355794,-0.065670155,-0.014957992,0.033252146,-0.097308375,-0.074321866,-0.07908747,0.075452045,-0.0313047,-0.08761019,-0.027528234,0.0032107073,-0.02863253,0.0968882,-0.040310342,-0.03487745,0.13194823,0.04845908,-0.016336916,0.017560266,0.024416788,-0.055271704,-0.006820373,0.046924714,-0.013371466,-0.019736903,-0.0097323535,-0.007876251,0.019722968,0.060856767,-0.016671585,-0.07258649,-0.049259312,0.0107319765,0.09327941,0.023533225,0.04026724,0.009749521,0.0005552273,0.048552677,0.0035505823,-0.04153488,0.036326785,0.008563252,-0.016921066,0.014605697,-0.0074408804,0.13255446,-0.031927,-0.046160795,0.036218755,0.0065462333,-0.068519734,0.009138779,0.12690476,0.03052724,0.056702357,0.011510921,0.08272651,0.028092666,-0.047861822,-0.085150465,0.007911881,-0.0029819498,0.03810759,-0.032283995,-0.062217884,0.023946822,-0.039922845,0.04265919,0.015154388,-0.11352312,0.10492709,-0.07309389,-0.027795732,0.027409453,0.008943964,-0.0123777175,0.014094638,-0.050444882,-0.009153721,0.02502122,-0.06834689,0.025264973,0.056621592,0.013582604,-0.075239964,-0.01353415,-0.044584032,0.049940474,-2.0183905e-33,0.037273884,-0.11199243,0.041979212,-0.048740953,-0.008027229,0.04652727,-0.007211469,-0.002022894,0.032536577,0.029402284,0.018933157,-0.03555225,-0.025259372,-0.060750667,-0.09691719,0.03888748,0.08906711,0.12540154,-0.02668058,-0.013990003,-0.043101538,0.020631704,0.027893191,0.0047705295,0.007199561,0.017907446,-0.0003259492,0.0045125666,0.04057807,0.0071561257,-0.02385841,-0.024408806,-0.09360446,-0.08763581,0.06130854,0.04917204,-0.081186354,0.032457687,0.008799868,-0.029860428,0.024349531,0.0073421514,0.046741296,0.06967389,0.031632822,0.054827746,-0.061614394,0.05948151,-0.05045074,-0.07088825,4.7872385e-05,-0.031316016,0.008152613,0.008566887,0.07711637,-0.0072653545,0.0418849,-0.0058396817,0.035768237,0.041844852,0.010941148,-0.04810887,-0.0035129064,-0.050766546,-0.02490377,0.0110275075,-0.0880124,0.002773678,0.064329304,0.022534262,0.016200783,-0.058568645,0.06707448,0.01683207,-0.090176605,-0.0046716016,-0.08119974,-0.069259,0.06800714,-0.013135311,-0.099412665,-0.030019686,0.0018290643,-0.031582467,-0.04974947,-0.08627751,0.043158367,0.025104241,-0.014447839,-0.026044672,0.03939725,-0.034424245,-0.03756975,0.052748952,0.014526857,-2.0412912e-08,0.06997136,-0.090712935,0.021441093,-0.021640286,-0.03702668,0.039653637,-0.008516122,-0.019193493,0.050629497,-0.023919899,-0.032999158,0.048416417,0.024456732,-0.020749751,-0.008631979,0.036681596,-0.075916104,0.0045624645,0.015466157,-0.038744256,-0.063849516,-0.0032170347,-0.088736326,-0.019505378,0.00797502,-0.029885583,0.006113035,0.05004562,0.055613417,-0.08448802,0.079921156,-0.042399086,0.028937042,-0.07059606,-0.047866926,0.00861222,0.009305058,-0.02883315,0.106374174,-0.07500946,-0.0059940508,0.0060102446,-0.06732014,0.08217959,0.025583476,0.018611955,0.020536901,0.10392632,-0.052329186,-0.027216025,-0.046571903,0.017473597,0.027697485,-0.040189836,-0.010886943,-0.034445364,-0.00886417,-0.0816915,-0.0142421825,0.031310447,-0.019052142,0.013748073,0.16947629,0.01790418 +5.3.1.17,"The enzyme is involved in the degradation of polygalacturonate, a later stage in the degradation of pectin by many microorganisms.",384,1.0,-0.016777726,-0.03164981,-0.0037323672,-0.022451643,0.00045729353,0.0013506284,0.017980205,0.024980737,0.027630625,0.017039146,0.0081630675,0.018884115,-0.051184833,0.07498827,-0.082760125,0.0339218,-0.09499098,0.015630629,0.009205459,-0.0078086485,0.11340009,-0.011803422,-0.06012637,0.013391246,-0.009783413,-0.01747537,-0.008585529,-0.02028113,-0.042502783,-0.043232273,-0.051781658,0.03431415,0.03748168,0.023108251,0.044494875,0.10902742,-0.016929507,-0.06529643,0.035275068,-0.031727612,0.06799599,0.016402595,-0.020381898,-0.029232511,-0.017950796,-0.01747483,-0.016193971,-0.05407323,0.0013130179,-0.0439784,-0.035662066,-0.06824937,0.045736026,-0.027036594,0.107487455,-0.0007055074,0.0153206205,-0.050499156,-0.075395755,0.039266516,0.036742494,0.037592445,-0.014099546,-0.0145676425,-0.07660403,-0.05209539,0.04341394,-0.07884205,-0.048190005,0.0147373155,-0.06713011,-0.015312458,-0.05601804,-0.022659538,0.039749954,-0.0055440483,-0.015615561,-0.0841309,-0.05649354,0.0029352116,0.051103067,-0.0042623254,-0.0010409094,-0.02700144,0.003208321,-0.027273022,0.09504649,-0.028623756,-0.025756309,0.014074392,0.06415367,0.029110827,-0.0058171614,-0.025017623,0.031587735,0.0031241672,-0.020585988,-0.093870156,0.08725332,0.0087949345,-0.053407285,0.0060943644,0.042539526,-0.13368127,-0.019278085,0.02872039,0.0042456635,0.08793194,0.07597031,0.03197817,-0.017570341,0.03568484,0.009866572,0.08900263,-0.039662395,0.08808215,0.024056818,0.013409377,0.046610076,0.02198567,-0.033432927,-0.042438067,-0.021985631,0.091237016,-0.07705936,-0.0080809025,-0.062219713,-1.9169091e-33,0.027166134,-0.08986095,-0.023333343,-0.065644406,0.043912183,0.0039526015,-0.007946563,-0.044338275,0.08462881,-0.07873803,-0.08891299,-0.061983366,-0.034081142,0.14687857,0.029868007,-0.0155883115,-0.007869413,-0.01902,0.07273041,-0.0023425699,0.027344316,0.023882456,-0.08887671,-0.02171492,0.032896604,0.08014758,0.032440566,0.057379153,-0.0038844792,-0.051360186,0.058995523,-0.0366353,-0.11399128,0.049155124,0.07638286,0.055481266,0.060436226,0.015961114,-0.016713178,0.0155814905,0.027343133,-0.012226988,0.042337965,-0.03060088,0.032501824,-0.024831977,-0.030329907,0.10165404,0.041698974,0.067857966,0.033091936,-0.0004582604,0.020760912,0.0050592534,-0.07466124,0.035409294,-0.004430205,-0.036726154,-0.002969645,-0.07112525,0.028430816,0.03906123,-0.0054489956,-0.010482236,0.007980921,0.05564102,-0.03651756,-0.017920967,0.011791792,-0.0011864966,-0.08971826,0.007916302,-0.063992776,-0.064454325,0.049701177,-0.045086566,-0.09653743,0.039317,-0.015574323,0.0597503,-0.013021142,0.006605503,0.031273764,-0.01039958,-0.06565619,0.06655345,0.024155073,0.028299818,0.055845916,0.059282824,0.008865991,-0.040717665,-0.048842814,0.09788499,0.0033715204,-5.6787976e-34,0.04548543,-0.075503066,0.08490015,0.05857955,-0.05005841,-0.0060826144,-0.05789889,0.08765097,-0.0028523472,-0.08401597,-0.029661078,-0.017476216,0.046831336,-0.027461564,0.048323646,0.048399054,-0.09134636,0.07608863,-0.062102053,0.022434436,-0.10250349,0.09812419,0.0006807022,0.023548698,0.08086742,-0.024756668,-0.009949783,0.028397655,-0.015085096,-0.03058804,-0.05775548,-0.026566034,-0.06011433,0.0062887096,-0.08269132,0.009531806,-0.037914954,-0.049630936,0.06402852,0.038793504,0.050962754,0.036380485,0.02927689,0.036076218,-0.011663903,0.077798404,-0.01183698,0.002657389,0.013541605,0.013840225,-0.021635499,0.043028817,0.05606102,-0.06767459,0.04433285,0.038737066,0.06400557,0.00795739,-0.06625718,-0.022243684,-0.020825721,-0.07678145,0.0918724,0.049480986,0.011168129,0.052290123,-0.01938478,0.07070324,0.027813599,-0.027694983,0.10887225,0.07652767,-0.0071165105,0.056540977,-0.020499084,-0.04242371,-0.15134545,0.009897592,-0.016983522,0.030205501,0.087283105,-0.015132502,-0.09625382,-0.087010585,-0.05948927,-0.038653042,0.06612357,0.086222485,-0.02864386,-0.016019374,0.0135962535,-0.044347428,-0.07524697,0.0448385,0.01253684,-2.4361427e-08,0.046384975,0.002039262,0.0047722855,-0.04116078,-0.00666089,-0.05849253,0.08847741,0.077702,0.035099175,-0.06267576,-0.05187234,0.052519362,-0.054592304,0.0410132,-0.0071027162,0.01950439,-0.05139289,-0.029696438,0.021790786,0.057236064,-0.107863925,-0.064417705,-0.09997392,0.12142774,0.0077553475,-0.03211701,0.033979002,0.11531834,-0.030002998,-0.010242119,-0.0025452704,0.07471722,-0.04907417,-0.029044162,-0.071610495,0.07796641,-0.027789436,-0.06782678,0.017761,0.06259692,-0.0002827259,-0.022230774,-0.01950694,-0.051583752,-0.023157999,-0.030663794,0.01824893,0.0071439957,-0.014195988,-0.024914915,0.084874555,0.04140759,-0.05560746,-0.014548952,-0.08204132,0.015905557,0.044512812,-0.022937542,-0.03770956,-0.010833299,-0.012472473,-0.005248741,0.16659847,-0.054103166 +5.3.1.20,Also acts on L-lyxose and L-rhamnose.,384,1.0,0.016655715,-0.13218649,0.019095838,-0.009626793,0.07176912,0.0968855,0.01268753,0.0028726242,-0.0013504601,-0.012696189,0.048608366,0.042587895,-0.06175634,0.051306985,0.016071895,0.07483866,-0.04866061,0.00853489,-0.023015127,0.024737855,0.0914976,-0.012601175,0.027583497,0.045616712,-0.013112181,-0.03245925,-0.02217505,0.00015585832,0.032811355,-0.11927206,0.015409582,0.03036513,-0.0050839917,-0.049183015,-0.102342546,0.0764587,-0.07080172,-0.031893212,0.016017292,0.059462547,0.0072787832,-0.07579719,0.047372792,-0.05630839,-0.07806979,-0.047682445,-0.105286285,0.0009061946,-0.022153627,0.08328268,-0.015846571,-0.11544046,-0.0134534575,0.07816179,-0.08246374,0.017057616,-0.1408575,0.04365276,0.057436343,-0.0033081162,-0.00016332942,0.07882587,-0.050755437,0.08555124,-0.073715754,0.013856555,0.008277321,-0.014375914,-0.015888164,0.009512028,0.05064556,-0.08299404,0.011440193,-0.040046036,0.018728735,0.043721087,0.0129786525,-0.050418522,-0.101372324,-0.004375056,-0.0043330076,0.02342142,-0.037578017,0.0010367162,0.015134575,0.010317755,-0.020277318,-0.025095796,-0.057541665,-0.017250141,0.034948315,-0.05088824,-0.046772692,0.03175886,0.0028363569,-0.0005374862,0.035925843,0.030147621,-0.017600682,-0.008041207,-0.065932415,0.008514165,-0.0023792698,-0.032825578,-0.04421902,-0.01839146,-0.027832264,-0.031851433,-0.027133483,-0.081290565,0.0005826088,-0.031267937,0.036340326,0.0003021416,-0.058388256,-0.0014971355,-0.030047888,0.0055400673,-0.055591058,-0.009371573,0.0774296,-0.02485212,0.008404608,-0.01489918,0.0106106745,0.052978992,-0.08323337,-7.0803143e-34,0.049031563,-0.033656456,-0.045178194,-0.02177763,0.052925073,-0.019719124,-0.07131547,0.019401968,-0.013839239,0.039808374,-0.043745138,-0.0051648235,-0.02080843,-0.008966578,-0.0649973,0.049155686,0.0603778,-0.0029663662,-0.042291317,-0.014941498,-0.004946087,0.14662227,-0.06606747,-0.002410685,-0.030480672,0.0690177,0.07832263,-0.011707484,0.0064555644,0.019562433,0.047319498,-0.021973314,-0.011159767,0.06218723,0.0031570538,0.1474667,-0.099138,-0.08085325,-0.027008742,-0.02749094,0.076925136,0.04596515,-0.085253775,0.0042020185,-0.034821104,-0.039249428,-0.05423837,0.011188447,0.0737748,0.042893235,0.11098738,0.026537007,0.0283602,-0.001579496,-0.011689105,0.012147946,-0.06419875,0.054071017,0.045926847,0.053940956,0.03248372,0.02148475,0.04027921,-0.0537771,0.0071952166,-0.010342101,0.013840705,-0.07704245,-0.044516943,-0.025759915,-0.0530725,-0.08098947,0.1558232,-0.016196702,0.09044816,-0.06848629,-0.03172688,-0.07065019,0.0096074855,0.047887783,-0.03305103,-0.057989616,0.017492928,0.018944731,0.031859297,-0.08655908,0.0040442212,-0.073694386,-0.011494202,0.0136131765,-0.026425866,-0.051679313,0.004716906,0.0012235049,-0.04260362,-8.954798e-34,-0.0063601,-0.052033532,0.076372914,0.06584755,0.013745325,0.049675442,0.038324293,0.029372158,0.0052838004,0.017358689,0.076044574,0.013066971,-0.093772866,-0.026611915,0.08418147,0.0062203975,0.06342067,0.043924447,-0.008948443,0.010117131,-0.044386428,0.062109288,0.03592493,0.06658732,0.052621227,0.032409552,0.053555552,0.026766745,-0.018494686,-0.007256943,-0.0032096503,-0.012407397,-0.07661733,-0.12058611,-0.056939658,0.09796757,-0.029765684,0.056514256,-0.03715754,-0.037099432,0.035719395,-0.0603223,0.07573091,0.11155447,0.021818768,-0.011603067,-0.012716932,0.012653982,-0.0440205,0.009448387,-0.03583435,0.02816432,-0.025989672,0.004342773,0.051211536,0.07144764,-0.05041839,-0.07364378,0.0031655575,-0.029988322,0.005333534,-0.008220507,-0.08477527,0.005263229,0.05088853,0.06279876,-0.03977004,-3.5396079e-06,0.066286325,0.035096098,0.08474676,0.0060870703,-0.00054726866,0.0067000804,-0.077838965,-0.11343097,-0.053673245,-0.16951661,-0.03254487,-0.07172532,0.043480583,-0.04293939,0.029984398,0.013007094,0.020137101,0.0039715157,-0.042922042,0.049054127,-0.020886896,0.024517942,0.024914311,0.023744287,-0.020889642,-0.009643525,0.081073925,-2.210107e-08,0.042601816,-0.006495854,0.053601325,-0.02687896,0.046088737,-0.029012246,0.007613338,0.044664063,-0.05419142,0.092046365,0.018484125,0.041187573,0.02681989,-0.059144244,0.11716177,-0.011730943,0.034328055,0.15419902,-0.08480187,0.07235368,-0.04462134,0.0003742561,0.046557743,-0.03017021,-0.022372648,-0.015589407,0.0652903,0.025682952,0.036323003,0.0029046778,0.072453775,0.02376992,0.02071739,0.029812641,-0.06893037,-0.031775635,0.0012073577,-0.0005884046,-0.027310641,-0.01435454,-0.008985207,0.005172626,0.028624821,0.07892911,-0.0991362,-0.052769583,0.03370861,-0.021489568,0.051711515,-7.519777e-05,0.043149043,-0.04961846,-0.03192968,-0.027512213,-0.051649176,0.0034412278,0.010579518,0.069251075,0.041286085,-0.073405996,0.011832596,-0.0048544323,0.13468014,-0.017619587 +5.3.1.21,An epimerization at C-20 and C-21 is probably catalysed by the same enzyme.,384,1.0,-0.0548,-0.019972052,-0.04627742,0.045258563,0.082766235,0.0968767,-0.04232626,0.05677792,-0.024483545,-0.018073987,0.0497048,-0.028540775,-0.03448928,0.075142175,-0.05226167,-0.0007928587,-0.12889619,-0.009168417,-0.011578108,-0.083889864,-0.013904319,-0.06729398,-0.023137478,0.0027561623,0.078939036,-0.0014804052,0.026716275,-0.047628682,0.0034510735,-0.042471223,0.05456672,0.0072203195,-0.01141032,0.0020834787,0.017963283,0.004862807,-0.08722402,-0.010274612,0.07027247,-0.04861567,0.003125913,-0.008244845,0.009692104,0.01975473,0.008824053,-0.03145283,-0.004389923,0.056784756,-0.05994646,0.023819488,0.017059702,-0.08874649,-0.056823794,-0.039344657,0.03150512,0.07534314,-0.048758708,0.036692083,0.05601287,-0.043386858,-0.021824418,-0.057726156,-0.03098191,0.020988004,-0.034118626,-0.06617426,0.04829974,-0.036222707,-0.0010849586,-0.039528728,-0.031975523,-0.056574203,-0.026720429,0.061466895,-0.03600056,0.03739993,-0.0024116258,-0.040406667,0.0037518134,-0.021808777,0.04403404,-0.0011686634,0.08226263,0.00957613,0.031371765,0.0014222169,0.050048683,-0.02843601,0.072984114,-0.012993075,0.05685842,-0.0007824543,-0.14213519,0.03578015,-0.1122479,0.026869984,0.062536016,0.05009709,0.03279884,-0.00059741765,-0.0043833507,0.052063327,-0.014257221,-0.050865885,-0.03324998,0.032798752,-0.004200141,0.087570965,-0.014976602,0.0148101505,0.05298484,0.057388645,0.07938189,0.05103321,0.0481475,0.09583781,-0.037761856,-0.023207247,0.035269465,0.015526189,-0.036618017,-0.015838377,0.007373901,0.04978911,-0.082479596,-0.004020093,-0.048027307,-8.501623e-35,-0.029195236,0.023237908,-0.01513113,-0.004098387,0.062263086,0.031706594,-0.040785838,0.027499769,-0.051808514,-0.06772138,-0.07048694,-0.09963839,0.0144151375,-0.017995803,0.00025827228,-0.016482035,-0.011309104,0.04432205,-0.033697657,-0.08676589,-0.014379282,0.08905118,-0.0653068,-0.053213347,0.03844786,0.022770481,-0.01191878,0.061869327,0.06867535,-0.029642493,-0.0075859264,0.02007053,-0.08521731,0.0651927,0.030466646,-0.006591715,0.03714472,-0.022063816,0.0062047024,0.0064367033,0.14077358,0.050129462,0.016523346,-0.049824614,0.04105785,-0.098853655,-0.012175821,0.089686826,-0.016343536,0.055519138,0.048372623,0.092190616,0.02640602,-0.027791316,-0.03676242,0.10617212,-0.035913773,-0.032879855,0.05419702,0.033267245,0.049915485,0.08953176,-0.0156236775,-0.04121993,-0.010021816,0.083531514,-0.0451802,-0.016931444,0.034454674,0.11099294,-0.05286854,0.012916004,0.0993362,-0.024203554,0.03232257,-0.047032215,-0.054420095,0.009842463,0.049139053,-0.052152205,-0.082108214,0.04068609,-0.031396613,-0.009739213,-0.018509397,-0.05178335,-0.11212369,-0.05092974,-0.026527507,0.07894613,0.06525276,-0.09409707,-0.048871543,0.037584703,-0.06357635,-1.8618712e-33,0.095878415,-0.11139617,0.07140301,-0.04127725,-0.011605728,0.06330351,0.018026957,-0.09190648,-0.022127187,-0.027518427,0.07690113,0.041089166,-0.02455551,-0.0080738515,-0.028338017,0.016333858,-0.02015146,0.1030194,-0.006428499,-0.0037498963,-0.06311413,0.027976884,-0.022281513,0.07496678,0.025226628,0.06568386,0.016068598,-0.0048721908,0.08224777,0.10874015,-0.017012138,-0.06507852,-0.027898781,-0.023585238,-0.043998778,0.08079129,0.002517378,-0.044823848,0.028892713,-0.032042593,-0.038399044,0.010481393,0.001005884,0.03826347,0.006091527,0.09354515,0.011409096,0.0021230446,-0.045118824,-0.047152374,0.015029786,0.01498252,-0.032617863,-0.018941004,-0.09156366,0.07423588,0.02304704,-0.027206412,-0.034574278,-0.047284365,-0.0066556386,-0.07335112,-0.012067698,-0.04137937,0.06611866,0.04379439,-0.091520324,0.0971983,0.054704815,-0.025964586,0.067712374,0.02869031,-0.034493625,0.030317768,0.0012132655,-0.04849976,0.0877653,-0.03925077,0.033058655,-0.09665379,0.008037507,0.014107215,-0.026745854,-0.0099726645,-0.02029356,-0.04103441,-0.05876238,-0.023995392,0.022819059,0.10913566,-0.05594283,-0.00663946,-0.0094053345,0.031949915,0.10743953,-2.225742e-08,0.006537134,-0.048017915,0.041113853,-0.03390048,-0.0061302567,0.011279301,-0.08063034,-0.036999222,0.06529408,-0.0692668,-0.0775812,0.023384482,0.0054647992,0.03763684,-0.013786371,-0.009606672,-0.09425509,-0.009414162,-0.047967352,0.014925813,-0.11568686,0.050052863,-0.014742861,0.043114252,-0.00706282,-0.06983836,0.038350303,0.12838435,-0.06897039,0.029895073,-0.05186955,-0.010355782,-0.008037467,0.06588663,0.090071216,0.021333728,-0.0085227555,-0.08573352,-0.046349846,-0.002046053,0.009215204,-0.09254509,-0.033698194,0.027322354,0.053279668,-0.053647,0.020145655,-0.015630549,-0.015544515,-0.012117153,0.048094,0.0015711038,-0.014091594,-0.08478207,-0.021538664,0.012463326,-0.044795774,-0.06396091,0.092079274,-0.00434143,0.010636795,0.0066083525,0.13750795,-0.034828022 +5.3.1.24,"In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase) and EC 4.2.1.20 (tryptophan synthase)].",384,1.0,0.0064840596,-0.018485365,-0.12161969,-0.02342435,0.06959427,0.03627655,0.003438716,0.0063793743,0.05788273,-0.0132042905,0.035539676,-0.059588354,-0.08586474,0.08133022,-0.03271733,0.027801286,-0.08407435,-0.003989058,-0.020775143,-0.079913296,0.05849623,0.082404785,-0.01611722,0.0072769574,-0.028674357,-0.033074427,-0.003170901,-0.069880545,-0.028045082,-0.02381251,-0.011627845,-0.0716344,0.00015405855,-0.058312546,0.043958485,0.10856807,-0.026032742,-0.03737844,0.07003767,0.014296362,0.013824981,-0.021731272,-0.022829542,-0.025460953,-0.029970141,0.09227744,0.04891271,0.024200551,0.044144504,-0.046176143,-0.050869647,-0.037227362,-0.06566681,0.01751444,0.059830572,-0.007576266,-0.072888575,0.009888006,-0.059180044,0.030694753,0.0043060402,0.052259505,0.05803658,0.02847365,0.061894525,-0.052012205,0.028283719,-0.08550064,0.0067213657,-0.009870445,-0.07513104,-0.030993573,-0.0002624186,0.025163487,-0.0124254925,0.059458982,-0.0017196422,0.005800874,0.0021022866,-0.036785156,0.043316994,0.016219484,0.014977233,0.05871105,0.004403864,-0.031121988,-0.03236485,0.07764065,0.033750392,-0.022873448,0.06551169,-0.02024198,0.043504864,0.0070133354,-0.010548797,0.010537914,0.01052281,-0.02091497,0.04984188,-0.067830145,-0.020857722,-0.0060319547,0.0010964742,-0.085220985,-0.038138233,-0.006586878,-0.025540581,0.085248835,0.047159735,-0.0028461479,-0.038393185,0.024480375,0.08325095,0.04315034,-0.016342297,0.060805857,-0.062813304,-0.06678766,-0.00993585,0.03942073,0.0198227,-0.01858678,0.067007765,0.13930455,-0.027400149,0.020607919,-0.10792606,2.1553234e-33,0.075410664,0.053098768,0.045258727,-0.030767635,-0.03595822,0.03583844,-0.032514542,-0.034849145,-0.06721529,-0.031101832,-0.028627893,-0.12852368,0.053250227,0.053079173,-0.00045559343,0.05365444,-0.075056314,-0.003635199,0.03372445,0.06351017,-0.05371767,0.044257995,-0.05068281,0.008661204,0.036489557,0.070825785,-0.019450858,0.010302731,-0.008348864,-0.027625082,-0.009300675,-0.046508476,-0.13546121,0.023202196,0.024790958,-0.067818455,-0.0068236073,-0.045156397,-0.09142032,0.017845932,-0.0032921005,0.040312476,0.0025204218,0.0050184885,0.09143705,0.010640286,-0.07776334,0.112804584,0.0912721,0.033758305,-0.03242153,-0.025782507,0.12686858,-0.054547038,-0.05003459,-0.022407683,-0.052478306,-0.009737695,0.026446046,0.029684553,-0.09864907,0.019144699,-0.058956463,-0.024238588,-0.029287925,0.013046142,-0.006353767,-0.0947485,0.010083016,0.073160045,-0.034344118,-0.03831072,0.06355118,0.023788702,-0.012261485,-0.07355062,-0.0330673,-0.043577634,-0.010241599,0.08177717,-0.00078602106,-0.0076176594,0.0036437681,-0.037366714,-0.008817141,-0.039708756,-0.015252684,-0.09437488,0.013396357,0.04844346,0.00012487786,-0.048335303,-0.109344564,0.06707512,-0.015840413,-4.243373e-33,0.07737201,-0.06462116,-0.008305528,-0.052806813,-0.04451978,0.05602023,-0.0005780762,-0.0007685738,0.05780301,0.0147800995,0.045932356,-0.062213782,0.109849945,-0.039051346,0.0058311564,-0.02033239,-0.03202881,0.10602297,0.09949092,0.015621578,0.012942249,0.03923049,0.0009306403,-0.0019995733,0.07120073,0.033985745,-0.10758936,0.09564537,-0.014525061,0.023677357,0.03628849,-0.028184744,-0.078761585,-0.015520678,-0.021045731,0.025184035,-0.0737846,0.02213282,0.08073472,0.01628309,0.05126081,0.08759497,0.08059331,0.02378598,0.020002278,0.10594555,-0.03827314,0.063668266,-0.0017833979,-0.079080485,-0.055711836,-0.02842486,-0.013041465,0.025715336,0.053000815,0.06497437,-0.015524927,0.08944327,-0.03323971,-0.050515316,-0.05892199,-0.0994932,0.09661495,0.0050093676,0.00662675,0.07225222,-0.00421067,-0.0029245906,0.07692476,0.043212824,0.036707737,-0.03536511,0.027426561,0.07483068,-0.03791539,-0.056080732,-0.099960335,-0.07945526,0.021401232,0.006700658,0.05277905,0.034165848,0.046347253,-0.046980456,-0.008260446,-0.02669767,0.04241187,0.14239529,0.024878576,0.010703422,0.012926661,-0.007995918,-0.049613863,0.057629216,0.041407727,-4.6267978e-08,0.07849239,-0.08798173,0.0148342475,-0.1389221,-0.027721114,0.022193419,0.03468793,0.045842502,0.023111705,-0.029834365,0.009573257,-0.017063353,-0.014128454,-0.013474994,0.023406431,-0.021876762,-0.024325324,0.035297688,-0.018819023,-0.017932562,-0.033044323,-0.05217801,-0.080916084,0.013242058,-0.006370036,-0.03456651,0.06303284,0.006849199,-0.037948094,-0.0380909,-0.05191051,-0.005309814,0.005373062,0.0029478213,-0.060756806,0.043323588,-0.097934596,-0.002118084,0.012612857,0.011346469,-3.773218e-05,-0.045978453,-0.05136219,0.03263294,0.062340245,-0.038570803,-0.013907943,-0.052888352,0.010169782,-0.06109195,0.031786133,-0.02298069,-0.017227264,-0.07292848,-0.0825677,-0.0053761303,-0.049193885,-0.04070607,0.0011783038,-0.04921746,0.039682727,0.042816676,0.17736594,-0.044048466 +5.3.1.25,"Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+). The enzyme binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism [3]. The enzyme from Escherichia coli can also convert D-arabinose to D-ribulose [1]. The enzyme from the thermophilic bacterium Caldicellulosiruptor saccharolyticus also converts D-altrose to D-psicose and L-galactose to L-tagatose [4].",384,0.99999994,-0.03458244,-0.07187954,-0.064210206,0.007099726,0.0019799636,-0.023145793,-0.01729979,0.032957587,0.06909411,0.08648008,0.01249737,-0.023551986,-0.032385997,0.042549927,0.004923806,-0.04492621,-0.025239136,0.070738345,-0.058273777,0.0045708655,0.1473311,-0.0017082477,-0.014373284,-0.020828292,0.05806972,-0.00017150003,0.039381176,-0.009830846,-0.071611516,-0.056738716,0.00023795811,-0.051030174,0.08959595,-0.045024477,0.065878846,0.097650744,0.041571047,0.005897398,0.050517976,-0.030129852,0.029967383,-0.0011387632,0.08211488,0.0028912895,-0.05056849,-0.014509805,-0.02257726,0.071344614,0.029114097,-0.015384023,-0.026704138,-0.05366271,0.0029071444,-0.030862689,0.032655194,0.067175806,0.031849373,-0.035285782,0.0013874584,-0.037077654,0.010392842,0.032993365,-0.013982037,0.02245712,-0.022902515,-0.11547239,0.054083586,-0.05321443,0.028949786,-0.05572526,-0.023987843,-0.046457183,-0.08710374,0.0046728346,0.0009192175,-0.003123756,0.015114367,-0.106271684,0.05257636,0.016393756,0.03321723,0.026562503,0.03726809,0.038906753,-0.04164081,0.028625637,0.07089405,0.0039213006,0.07966713,0.0019762898,-0.0064608604,-0.018307114,-0.017115884,-0.047818493,-0.055825163,-0.018615983,-0.0005007517,0.030513762,0.027146157,-0.029844783,0.01691082,0.06421023,-0.058527626,-0.1005839,0.016284918,9.450251e-05,0.030839056,0.13215749,-0.03192006,-0.044880077,0.08070201,0.0026765394,0.056857694,0.04111076,-0.043794252,0.02375586,0.08379622,-0.10337182,-0.06118576,-0.004407736,-0.0019469134,-0.023062209,0.01574144,0.02493154,-0.055649277,0.11018522,-0.09072917,3.330577e-33,0.054739382,0.0041013844,0.0102570765,-0.02949433,-0.02061845,0.008851515,-0.11668085,-0.037908338,-0.03868123,0.012339454,-0.088518724,-0.077337645,0.03559763,0.0682075,0.007823974,0.002434439,0.010223908,0.0027538626,0.039809514,0.0243932,-0.01894959,0.0869203,0.011062528,0.008101657,0.033781897,0.08722902,0.014292917,-0.022914136,0.12229514,-0.004285864,0.026090188,-0.04996138,-0.09500186,0.06469399,0.040073335,0.047390036,-0.0746975,0.0066807577,0.009044411,0.014438454,-0.0033135049,0.017184585,-0.027741026,-0.008969323,0.05187932,0.015698208,-0.011916071,0.05346859,0.026881944,0.06515233,0.059513763,0.016574193,0.073719986,-0.07311543,-0.07441766,0.038903747,0.015144045,0.012682455,0.026291767,0.07415102,-0.055480924,0.04081952,-0.009690849,0.043544594,0.048489656,-0.023687208,0.029271394,-0.11088438,-0.03153389,0.029039303,-0.09694053,-0.08049402,0.039440706,0.016642341,-0.013824374,-0.018486131,-0.09413238,-0.093249775,0.09337826,-0.07087216,-0.0038655011,0.03590992,-0.021990767,-0.04501496,-0.033115774,-0.029428717,-0.08776558,-0.052564062,-0.016172009,0.04282771,0.0001394344,-0.041637376,-0.049206514,0.06766817,0.03807741,-5.122551e-33,0.051006492,-0.050165724,0.054158762,-0.063146375,-0.08596633,0.0137662,0.009234766,-0.0402308,0.035798643,-0.04795833,0.076378085,-0.015054498,-0.010217911,0.003564614,-0.017517932,-0.005564316,0.0035828315,0.04959586,-0.03270634,-0.0195877,0.028018301,0.093105,-0.0040888735,0.015389157,0.061627865,-0.027876172,0.0038074262,0.09543942,0.050221555,-0.00017118093,0.031739376,-0.02026126,-0.025480643,-0.07629604,-0.097501256,0.0869572,-0.027644185,0.0268063,0.06530784,0.02621663,-0.10919343,0.037732005,0.06363872,0.035453096,0.027099365,0.01312329,-0.043369733,-0.013316214,0.013813026,-0.020614795,-0.0050323205,-0.058120303,-0.0040474534,-0.0115679065,-0.0028250401,0.022811212,0.035039175,0.0652284,-0.06412454,-0.040885046,-0.051593374,-0.072629,0.1311136,-0.024732487,0.005666998,0.06385389,0.007326174,0.015110648,-0.01427224,-0.040340785,0.09208138,0.026860697,-0.010003199,0.010496485,0.06912258,-0.10291104,-0.10119282,-0.035662156,-0.010674068,-0.033784546,-0.0069100563,0.04056468,-0.020402692,-0.008157426,0.051117346,-0.14065608,0.09681907,0.047509823,-0.03449353,0.049280994,-0.043018945,-0.05721878,0.028026145,0.047906812,0.071660444,-4.5572367e-08,-0.01116008,-0.046150587,9.049003e-05,-0.09841145,-0.032612164,0.05105225,-0.010215027,-0.016217802,0.048520237,-0.040297776,-0.0162445,0.14195661,-0.026901646,0.05463904,0.03744855,0.040029548,-0.042569183,-0.0013403924,-0.030652575,0.011982007,-0.03407129,-0.03371081,-0.13912041,0.004560882,-0.013475458,-0.038682897,-0.007590501,0.0074139507,-0.011415662,0.04342634,0.019157615,0.06706435,-0.03174905,-0.047126025,-0.06182638,0.013036124,-0.07498965,-0.040412836,0.0035875307,-0.004892842,0.051691223,-0.012054362,-0.055886257,0.023822693,-0.039773624,-0.046536233,-0.040056173,0.09044772,-0.034556903,0.05624625,0.10317159,-0.058960695,-0.04469464,-0.08636106,-0.08851194,0.020389812,-0.0031848266,-0.05611155,0.011694873,0.06853892,0.04451855,-0.039839763,0.123832196,-0.092016876 +5.3.1.26,Involved in the tagatose 6-phosphate pathway of lactose catabolism in bacteria.,384,1.0,0.033472415,-0.05483914,-0.0827314,0.009991659,-0.0059334654,0.06314602,-0.015833016,0.054763865,-0.009037028,0.009771335,0.017598439,0.004507557,-0.07122099,0.020346418,-0.04811528,-0.0032745886,-0.09879599,0.03852765,-0.028019818,0.026540259,0.10232765,0.006500605,0.021153765,0.0037611558,0.0824105,-0.0008084448,0.08400596,-0.0073704557,-0.046865027,-0.02601288,-0.005928833,-0.03580535,0.035577916,-0.02260356,0.055904612,0.10648784,0.09373409,-0.021545425,0.10186433,-0.03310998,0.031527087,-0.025200097,0.037535045,-0.028346233,-0.0041950466,0.032946363,0.011366846,0.072031185,0.03716703,-0.04212609,-0.09067537,-0.059401996,0.03402814,-0.001910497,0.04595213,0.047411703,0.0005541691,-0.09317121,0.016390176,-0.0099549275,-0.025231976,-0.041189317,0.055003736,0.080729745,0.021098677,-0.022103777,0.024245504,0.003686755,-0.036840368,-0.0118030915,-0.06885055,-0.04171829,0.04993353,-0.044980608,-0.065487,0.046499953,-0.027326906,-0.041355982,0.012664854,0.0011083145,0.005264367,-0.06678186,0.02671322,0.06222332,-0.055995695,-0.09832875,0.07333511,-0.016727261,0.03620726,0.03526299,-0.021725439,-0.00989847,0.01006449,-0.12165922,-0.07369815,-0.018404644,-0.021241838,0.0136536565,0.06766558,-0.041195616,-0.020365076,0.0031197565,-0.005759709,-0.019262414,0.018301621,0.02649863,-0.009157497,0.13118047,0.04542183,-0.016823292,0.03174493,0.040997703,-0.020086328,0.012543028,0.0142111005,0.059859395,0.10090971,-0.08752162,-0.0511512,0.0690583,-0.086823806,-0.005724159,0.0394914,-0.024345772,-0.06652901,0.028629836,-0.029691637,-7.695924e-34,0.06443515,0.016850853,0.072049715,-0.08388636,0.03967461,0.01584755,-0.094023846,-0.056244377,-0.041354347,0.03921054,0.007188404,-0.0937464,0.05257247,-0.05067294,0.038904894,0.031903334,-0.053597495,0.010429795,0.01975795,0.023004547,-0.03767979,0.017752144,0.018438295,-0.047398888,0.0085221855,0.11501818,-0.015417995,-0.018565755,0.004182046,-0.00254272,0.06502933,-0.005486048,-0.10222397,0.051333632,0.0487677,-0.016124163,-0.0788209,-0.0019056797,-0.03874192,-0.005388819,-0.010851598,-0.030821,0.0036454427,-0.08059519,0.035371833,-0.073402785,0.032057866,0.027676756,0.05252798,0.10837403,0.013076806,-0.047065493,0.064962655,-0.02546664,-0.018468216,-0.030871881,-0.018059142,0.039794896,0.05510022,0.055183828,-0.005184782,0.0018790923,0.0043260464,0.018339686,0.08125681,-0.024130818,0.060298126,-0.018740816,-0.017747074,0.05929776,-0.05175835,-0.0550008,-0.027502304,0.044029552,-0.0012346221,0.026427021,-0.08687301,-0.05098583,-0.027198518,0.02511703,0.030003631,-0.07254783,-0.004254816,-0.005828037,-0.05395387,0.051014304,-0.112477325,-0.051482107,0.039282642,0.039387975,0.11635729,0.0020329822,-0.13945462,0.011960217,0.019412963,-6.1396745e-34,0.17660245,-0.052285396,0.0066100955,-0.068895265,-0.067814805,-0.0445018,0.0487895,0.0724821,0.007721207,0.0057986914,0.038139712,0.0063332804,-0.038047258,-0.008293352,0.0008236082,0.044676162,0.058534224,0.064210005,0.055407964,-0.009260868,0.08122364,0.07903155,-0.06564984,0.06654651,0.09536408,0.040238984,0.014865039,0.025412643,-0.007085762,-0.058645733,0.008550635,0.03484968,0.01092218,-0.099334024,-0.033130795,-0.055366598,-0.07018651,0.02926057,0.08787698,0.017651431,-0.04728534,0.075534925,0.022417342,-0.01326056,-0.001270022,0.015925573,-0.011168672,0.013324167,-0.019676143,-0.002146316,-0.031219268,-0.075037666,-0.040684152,-0.012757662,-0.027537782,-0.0015502657,-0.0016564822,-0.02260276,-0.038392216,-0.043004792,-0.0033874034,0.0047304262,0.07990379,-0.060748473,0.020001361,0.06547358,-0.03278266,0.027624212,-0.023108501,-0.016461503,0.013281212,0.026278527,-0.032595202,0.052247107,-0.020493923,0.012147013,-0.10027698,-0.020658407,0.026610598,-0.025352284,-1.2250296e-05,0.010516549,-0.04702376,-0.0030519736,0.06942351,-0.040847115,0.022853008,0.03237851,-0.043628067,0.007287892,-0.01383791,-0.032045405,0.0024021599,0.024174614,-0.016173296,-1.9893738e-08,0.05049809,-0.11102085,0.0017685527,-0.028949711,0.052716553,0.013330199,0.00573039,0.05962873,0.03640215,-0.052702777,-0.0024001373,0.08982046,0.017105559,-0.011695901,-0.037669603,0.01330691,-0.037483573,-0.106271386,-0.05110594,0.01236962,-0.0711658,-0.07658644,-0.10128601,0.07334217,0.1260924,-0.0044814167,0.02019354,0.054045018,0.007993838,-0.06191157,0.077366635,0.019095186,-0.061649136,-0.031085087,-0.011359741,0.06573073,-0.032769572,-0.14165108,-0.00068293547,-0.006953691,0.013846647,0.0013224871,-0.046474077,-0.03753548,-0.009088336,0.06795913,-0.07589477,0.038917016,-0.054793138,-0.018506262,-0.0086010685,-0.046765696,-0.046286453,0.038353983,-0.0016389341,0.026081767,0.11815923,-0.09351656,0.024433274,0.03968163,0.0934049,-0.012731404,0.17139053,-0.10807382 +5.3.2.1,Also acts on other arylpyruvates.,384,1.0,-0.01542032,-0.1488942,-0.03619325,0.09686954,-0.018162027,-0.011553051,0.055759158,-0.017404987,0.019600626,-0.00045380677,0.058552254,0.04106908,-0.04550494,0.1207004,-0.0010816812,0.083113015,-0.10353847,0.013958011,0.02282329,0.0075861467,0.037977032,0.061755553,-0.012316679,-0.06524745,-0.014313446,-0.035376824,-0.008939512,-0.0066189766,0.04301218,-0.09399283,-0.02899945,0.014429853,-0.03168545,-0.025242183,0.04305596,0.1049829,-0.05378908,0.042634748,0.053806942,-0.02128421,0.048572466,-0.028194727,-0.03144421,-0.019164251,-0.026274046,0.015554632,0.011847522,0.031704195,0.020170473,0.045900997,-0.06572411,-0.05571886,-0.030991679,0.061270785,-0.0455947,0.030405024,-0.095547184,0.012224866,0.006613735,-0.05098089,-0.04846374,-0.0043138675,-0.014863542,0.022673175,-0.013303657,-0.004246852,0.0758351,-0.03446049,0.025321675,0.0048239613,0.051491294,-0.05411076,0.0076119984,0.025032617,-0.0006320503,-0.01407982,-0.015679145,-0.103715904,0.041692514,-0.0038027249,-0.05955658,0.06765287,0.03541675,0.021422539,0.04798906,-0.028671594,-0.0050539332,-0.0803975,-0.1009927,0.061667975,0.03244592,-0.06354881,-0.018091133,-0.019335147,-0.011394888,-0.03586835,0.05059567,-0.043931928,-0.045383736,0.004049259,-0.050648313,-0.037330545,0.009364882,0.018323984,0.0065434296,0.018818688,0.012865709,-0.06667459,-0.058573704,0.0010001159,-0.042904418,0.007749542,0.059800934,0.0024363184,0.0038840808,0.07892934,0.022998715,-0.00637043,-0.036674432,0.014393908,-0.0009671687,-0.031933002,0.027100807,0.011489411,-0.051777374,0.026775876,-0.07838946,-5.303091e-34,0.05814484,-0.02955332,-0.026783021,-0.026326906,0.06305859,0.02341564,-0.07023348,-0.010688626,0.040062696,-0.024185358,-0.046002854,-0.082042366,0.11581798,0.046501603,-0.07566591,0.019989911,-0.054193895,0.06663293,0.026319953,-0.04397784,-0.015759138,0.11626185,-0.019149227,-0.032996655,-0.0773932,-0.014662396,0.002306273,-0.0009669691,-0.015723985,0.00899566,0.054712445,-0.026843393,-0.03806743,0.07456012,-0.003540702,0.11726656,0.01531138,-0.04883913,-0.011062913,0.02639184,-0.0068097245,0.04821847,-0.108520694,-0.048251703,0.014439848,-0.075682886,-0.04132829,0.062226467,-0.018039653,0.016411021,0.112687446,-0.018066825,0.11886262,-0.0054791905,-0.008764929,0.03968886,0.010247355,-0.02803857,0.03510935,0.029429484,0.0661221,0.027787087,0.01811711,-0.0052695405,-0.005078066,0.016754389,-0.08513732,-0.055844437,-0.06920172,0.029691862,-0.09711241,-0.014412809,0.09706767,0.025897117,-0.014162502,-0.04916559,-0.054515284,0.0134412395,0.0026775165,0.035501886,-0.08353228,-0.086628474,0.09315295,0.0074217287,-0.030761693,-0.003081759,-0.0020151632,-0.07256878,-0.0036144387,0.0145985745,0.08170534,-0.0038357875,-0.05695266,-0.0043889354,-0.00020435928,-1.1490677e-33,0.021998568,-0.08324594,-0.016520321,0.00829021,-0.06031466,0.078896165,-0.012233335,0.05769475,-0.02425992,-0.02017428,0.03281489,0.017846793,-0.043197893,-0.022723518,0.07439068,0.016772028,0.07544518,0.07996466,0.018108562,-0.03389524,-0.054585062,0.08880143,-0.021981249,-0.0043280534,0.037079036,0.04899672,-0.06031445,-0.06565488,-0.02211848,0.060183696,0.008179166,0.0039190007,-0.115614235,-0.082455315,0.019063406,0.053542748,-0.0452374,-0.019760577,-0.07928789,-0.074960314,0.065107234,-0.024076138,0.14024718,0.13024257,0.08301761,0.020896554,0.029585699,-0.013719478,-0.10593989,-0.049109697,-0.021822972,0.0066760615,-0.005032678,0.00286975,0.03409454,0.065533206,0.03157216,-0.09757859,-0.03276553,-0.037100833,-0.043399714,-0.016018206,-0.056788657,-0.0686909,0.09797317,0.029683229,-0.056446616,0.0059326943,0.105366506,-0.036796413,0.102047116,0.0335915,-0.071616,0.032776166,-0.060225077,0.018639367,0.03490556,-0.057184927,0.031214254,-0.049002476,-0.051236663,0.0001871831,0.024811469,-0.032839708,-0.084860675,-0.03923686,-0.05950081,0.039927594,0.025771562,0.03170398,-0.045488484,-0.012224776,-0.033582345,-0.029610794,0.048730325,-1.9474184e-08,0.021850877,-0.00022938296,0.060657553,-0.022188399,-0.034103043,-0.02013663,0.039272714,0.10743005,0.032692533,-0.026280558,0.014012511,0.06605444,0.13498561,0.0116917975,0.092458755,-0.017496565,0.025910344,0.026597388,-0.091082275,-0.052097697,-0.12205373,-0.02401608,-0.00480119,0.07573986,-0.05258779,-0.08777019,0.052989915,0.023988543,-0.020595616,-0.046943057,0.076422855,-0.02370607,-0.03813703,-0.03032651,-0.009931761,0.05357201,0.07557398,-0.081488,0.04838693,0.031456944,-0.05387392,-0.023605438,-0.028644467,0.049258374,0.006118697,-0.020962344,-0.02489074,-0.053943347,0.03081659,-0.03252199,0.052597187,0.028502941,0.03422603,0.012569511,-0.048212472,0.0325518,0.0032312581,-0.02801733,0.091523156,0.003186196,0.07535709,0.05617646,0.12030568,0.011101299 +5.3.3.1,"This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).",384,0.99999994,-0.040117275,-0.036882624,-0.082535036,-0.0209624,0.044027902,2.4512208e-05,-0.080336,0.0064941673,0.0035027948,-0.039230894,0.01987805,-0.037871923,-0.0798004,-0.048662316,0.022663627,0.040571976,-0.07208675,-0.0066874735,-0.021281043,-0.06984906,0.042722393,-0.023023857,-0.040277723,-0.011912477,-0.0112762395,0.038464982,0.057208084,-0.012951563,-0.057557832,-0.097628534,0.053991232,-0.05452858,0.071072504,-0.0055075265,-0.04761062,0.059796598,-0.049736835,-0.11702974,0.0007248785,0.073111676,0.048314877,-0.057160795,-0.035849437,-0.065686986,0.002740891,-0.09966538,-0.04201292,0.05045624,0.027543528,-0.008328849,0.0058207233,-0.06270187,-0.028109157,-0.018209316,0.0029789298,0.012958707,-0.088331364,-0.018379357,-0.025679518,0.0536716,0.02814147,0.0069838506,0.0050063087,0.021005409,-0.02048658,-0.053920902,0.018512275,-0.073461585,0.029734295,-0.04346521,-0.04919638,-0.09526594,-0.046853267,0.031861752,-0.052032273,0.06171156,-0.072112,-0.09514319,0.038756732,-0.052806597,0.023267647,-0.013996978,-0.021343756,0.10880632,0.10959764,0.0011712655,0.003711529,-0.0014995987,0.028814072,0.07967491,0.033355873,-0.019047193,-0.008066252,0.03310937,-0.064409785,0.039411973,0.02524749,0.07873356,-0.012520984,-0.039604817,-0.0037617676,0.09493243,-0.05653411,-0.0567921,-0.03233668,0.027770553,0.046662718,0.07612741,-0.04728762,-0.03408716,-0.010963606,-0.08639635,0.020103786,-0.027816836,0.014384378,0.15506415,0.012569335,-0.07167716,-0.06969259,0.006931059,0.06625084,0.0004898191,0.01524213,0.04937803,-0.040270347,0.030173248,-0.043794326,-5.5563087e-36,0.028326908,0.008526865,0.0105097825,0.009974369,-0.01772803,0.045000643,-0.071493745,0.056593966,0.0029895857,0.004690196,-0.013515486,0.05371786,0.09736693,0.030905666,-0.010101735,-0.0554268,0.036920168,0.02837861,0.043009125,0.02326847,0.01837244,0.031745933,-0.06904918,-0.016232273,-0.026005218,0.03973354,-0.019242682,-0.0025365627,0.057520457,0.018661318,-0.014372885,-0.12184988,-0.03854779,-0.0017676166,-0.004018676,0.026724076,-0.025112232,-0.0043575335,-0.022000697,0.08182017,0.008974251,-0.05659867,-0.024906833,-0.06797957,0.005169263,-0.017648507,-0.035855375,0.0797351,0.09395163,0.010950786,0.03902732,-0.013620782,0.094338715,-0.009509181,0.0031671443,0.08353465,-0.032982416,0.024637684,0.011886479,0.07185195,-0.0012561613,0.08038893,-0.10279997,0.0257447,-0.028544357,0.045400046,-0.049499705,-0.079200454,-0.04477968,0.062177427,-0.059722416,0.050988723,0.07572411,-0.031258274,0.0552685,0.052325584,-0.007545078,0.063926525,-0.028429586,0.012400084,-0.053676084,0.008413469,0.0341783,-0.0001268269,-0.0068061766,0.09837879,-0.053040795,-0.035874654,-0.013169269,0.06651239,0.03666499,-0.072618805,-0.047078423,-0.022576671,-0.0004958311,-1.7886989e-33,0.0231667,-0.09200836,-0.025322681,-0.13425629,-0.02458843,0.1434856,-0.000412899,-0.039542906,0.04977927,0.002875941,0.010782401,-0.0043776957,0.05099548,-0.12658887,0.03985938,0.023352992,-0.05745297,0.036897272,-0.042380944,-0.014366655,0.01733187,0.08313686,0.06321697,0.12722625,0.055902734,0.032786485,0.047524255,-0.029365174,0.10807199,0.07842595,-0.057300452,-0.04568225,0.01599045,-0.0032323706,-0.024223702,0.08648405,-0.07329791,0.03233531,0.032589674,-0.0024823318,-0.09983294,-0.0001779346,0.03937364,0.02631207,0.04017992,0.08220243,-0.07548538,0.058483955,-0.030727329,-0.040470537,0.016752725,0.022406477,-0.05189052,0.02134126,0.020729223,0.07114402,0.043352675,0.003511575,0.08586249,-0.05454364,-0.02337422,0.0070276335,0.018731235,-0.016613327,-0.007595501,0.03641735,-0.03846093,-0.014313147,-0.046585683,0.0062800166,0.07131219,0.025993995,-0.04786622,0.023502816,0.007433814,-0.010651444,-0.06848276,-0.037508845,-0.0304948,-0.005368081,-0.0013208879,0.003431013,0.019054309,-0.081789315,-0.023465872,-0.027866976,-0.003703846,0.07710395,0.07162667,0.061101113,-0.028171966,0.0063947407,-0.12064827,0.029465426,0.047633365,-3.381129e-08,0.037108745,-0.07021871,0.05981443,-0.014490826,-0.007686864,0.058039233,0.03875067,0.020426603,0.10838052,-0.05844827,0.025154248,0.11107041,0.039977416,0.017352464,0.009084543,-0.028689414,0.012048589,0.01447162,0.0064818272,-0.023166737,-0.027892098,-0.030419417,-0.04291798,-0.0035238587,0.0054962276,-0.07727517,-0.012542663,0.013288002,0.00021533594,-0.032545935,0.020781344,0.015874792,0.005969811,0.011574838,-0.011235365,0.052118108,-0.01075961,-0.023545103,-0.081439555,0.077702515,-0.0680624,-0.104551286,-0.040040363,0.012303764,-0.002887973,0.019229352,-0.0033779452,-0.0018919316,0.020332523,0.0001860413,-0.021662192,-0.038757913,-0.006217092,-0.03314223,-0.078507416,-0.005861665,-0.02979564,-0.14057723,-0.023748089,-0.06871483,0.007329272,0.07261146,0.21476354,0.058652464 +5.3.3.2,"The enzyme from Streptomyces sp. strain CL190 requires FMN and NAD(P)H as cofactors. Activity is reduced if FMN is replaced by FAD, but the enzyme becomes inactive when NAD(P)H is replaced by NAD+ or NADP+. That enzyme also requires Mg2+, Mn2+ or Ca2+ for activity.",384,1.0,-0.020122146,-0.05091399,-0.10262969,-0.019062912,0.033762585,0.07620023,-0.050228022,0.033275414,-0.0011035355,-0.059933767,0.009982898,0.0077958573,-0.055326,0.096527055,-0.032820083,-0.0447849,-0.030039458,-0.039615132,0.062843606,-0.007764109,0.07344408,0.03941712,0.009802289,-0.048613206,-0.0002308542,0.008955682,-0.020453082,-0.03031406,0.015095192,-0.027333742,0.0273436,0.06671917,0.07627008,-0.04735358,0.0629892,0.07744183,0.004981598,-0.04558988,0.026939536,0.02482152,-0.0145103,0.008548243,0.010607808,0.011057329,-0.02891062,-0.007896199,0.06535442,0.026376842,-0.021196477,0.0018648081,-0.007099358,-0.042735975,-0.03053901,-0.004653054,0.07881545,0.05137859,-0.009057118,0.0052593867,-0.027332528,-0.052874282,-0.00798896,-0.03286015,-0.018917782,-0.029320626,0.08682469,-0.033770844,0.027481955,-0.09205104,0.01934718,0.0042469734,-0.112058766,-0.001036502,-0.040081047,-0.09431298,0.0034808682,0.05553514,-0.05000242,-0.058326714,0.022895547,-0.026081339,0.01660391,0.0063180095,0.02523852,0.063383505,0.062622696,-0.0502101,0.05177825,0.0066696536,0.013272664,0.09548083,0.060934607,0.009218032,0.0021059313,0.0121951625,-0.08089964,0.07409149,-0.04817474,0.053290553,0.004796259,0.013672204,-0.01382693,0.09050063,0.025609232,0.031519495,-0.041587085,0.0148511855,0.012163762,0.12261926,0.04957312,0.013556828,0.044669066,0.07268758,0.02586338,-0.065586776,0.001830381,0.050429486,0.036578126,-0.10951565,-0.03041226,-0.014298918,-0.025783991,-0.041453175,0.023103444,0.049843483,0.012465729,0.06634615,-0.1450457,4.6941607e-33,0.045528017,0.023901917,0.05522172,-0.06669459,-0.032323766,0.006198009,-0.05856612,-0.020712687,0.033933427,-0.09156966,-0.044201653,-0.05630158,0.008871527,-0.012490692,0.00880197,-0.059013672,-0.006051489,-0.025185693,0.06261716,0.0028555614,0.07039518,0.04018214,-0.0010682052,0.0045040823,0.073886625,0.044636752,-0.024721846,0.064004056,0.010345503,-0.02764842,0.05549409,-0.10852566,-0.07215182,0.013281607,0.04573492,-0.0136918,-0.05217647,-0.051409874,0.020478461,0.008452321,-0.0468846,0.048644274,-0.018399814,-0.017598124,0.0724901,-0.17461282,0.012904097,0.10892498,-0.025299748,0.112952,0.029293222,-0.028071964,0.04542417,-0.027113391,-0.05430062,0.03478075,-0.0025565273,0.018891122,0.03917585,0.03921633,0.08116954,0.012326379,0.02000421,0.08671524,0.08798852,0.04922115,-0.034333553,-0.04961592,0.034932893,0.079402335,-0.053457916,-0.03637109,0.023972483,0.01610636,0.018428026,-0.029731877,-0.022611758,-0.029640792,0.024574576,0.0239683,0.019015478,-0.004017051,-0.041293267,-0.08155273,-0.10931251,0.031479385,-0.018276332,-0.078159645,0.0038089433,0.03429019,0.06255773,-0.08494672,-0.01957691,0.017041123,0.047993623,-4.633714e-33,0.06954859,-0.053658232,0.06750614,-0.1092851,-0.11047527,0.085450396,-0.0046891933,-0.114806354,-0.013396821,-0.031990446,0.031534266,-0.04245904,-0.025331436,-0.055923276,-0.017145883,-0.0011156234,-0.057663053,0.06803442,-0.0365784,0.046366308,-0.029478988,0.16472149,-6.589713e-05,0.055474326,0.0032923603,0.0069924155,0.012956935,0.06551993,0.06866559,0.021537447,-0.024340682,-0.0096097095,-0.048627764,-0.017011,-0.03774189,-0.006620179,-0.054651506,0.041073818,0.016852695,-0.004852823,0.0939179,0.0760194,-0.004419578,0.077271596,-0.013749731,0.04279799,-0.11908375,-0.029228635,0.05102078,-0.05329559,0.010606377,0.024536954,-0.07147515,-0.0414077,0.04044787,0.035030663,0.008109411,0.007472753,-0.04209295,-0.049806975,-0.0064376295,-0.027519299,-0.016746107,-0.04699101,0.07890592,0.011434687,-0.008881293,0.084341176,0.0808193,-0.00014724796,0.01321364,0.06671291,0.023228021,-0.002114745,0.0015364992,0.031734206,-0.09391959,0.06145726,0.02754011,0.01962429,0.029555552,0.006822312,-0.07213417,-0.08279755,-0.01976383,-0.041417815,0.001182935,0.010962542,-0.002537666,0.030309532,-0.016737958,-0.010823458,0.03187859,0.02495308,-0.03805604,-3.7266634e-08,0.020712163,-0.028323103,0.074599855,-0.03195692,0.015868746,0.003548564,0.002173843,-0.101955675,0.0035670055,0.036976848,-0.024009872,0.0067157815,0.022605214,-0.04810035,0.030240934,-0.036111478,-0.047233492,0.0052419067,-0.06855789,-0.07348767,-0.11760389,-0.025331026,-0.10157982,0.16292335,0.039912924,-0.04555895,0.075847186,0.051988073,0.03226319,0.00014782752,0.023995774,-0.02594798,-0.0064865416,-0.025698017,-0.08799351,0.008687045,0.002862045,-0.036619555,-0.058775768,0.06566802,-0.0055046123,-0.05833292,-0.039462678,-0.0015104532,-0.077717654,0.026421871,-0.035849262,-0.028487504,-0.10051874,-0.014692147,0.100129336,-0.015237464,-0.06880154,0.00073025504,-0.08668513,0.08156709,0.05886587,-0.058033295,-0.05376938,-0.05203763,0.04835094,0.006543195,0.07625163,-0.068397366 +5.3.3.3,Also acts on 3-methyl-vinylacetyl-CoA.,384,1.0,-0.056738727,-0.058235366,-0.057084426,-0.0196523,0.04537277,0.012288882,-0.054970875,-0.0029441232,0.0629747,-0.028624944,0.053790703,-0.04340426,-0.052857812,0.035276286,0.018977994,0.04133662,-0.07325833,0.045492772,0.022082673,0.01005279,0.022819137,0.059134,0.022388168,-0.027772754,0.00090297114,0.053354595,0.0052206926,0.024450816,0.0657564,-0.0700807,-0.029768907,0.05625085,0.0030103617,-0.01973292,0.044216413,0.04015819,-0.06984476,-0.03580118,-0.023162654,0.06965896,0.103383,-0.10390658,-0.06360713,-0.058446378,-0.052413903,-0.058685053,-0.0038650502,-0.05113363,0.0437617,0.046223626,0.01888302,-0.018995166,-0.03874366,0.090736456,-0.03048962,0.0043636984,-0.041224793,0.08791173,0.0033894666,-0.009442624,-0.027624695,0.018345635,-0.06495751,0.055846017,0.054396566,-0.0014437711,0.025718804,0.0003773027,-0.019349748,-0.031551506,-0.013654618,-0.025160456,-0.012301238,0.037245523,0.009595518,-0.008455924,0.028544027,-0.07506886,0.038161635,-0.000630049,-0.0567854,0.07554602,0.030088931,0.040068284,0.016416436,0.057153385,-0.076571934,-0.06862112,-0.08399569,0.035994437,0.016842378,-0.003656926,0.023648534,-0.0080668675,-0.039648883,0.085056804,0.033789493,-0.035221927,0.021603819,-0.008744819,-0.029704107,0.07236108,-0.111364976,-0.049219847,-0.00077332626,0.00087551156,-0.013452534,0.06389993,-0.051696055,0.009476856,-0.03576779,-0.028377723,0.05261185,-0.020851867,-0.06784189,0.108051814,0.033320587,0.025967488,-0.014072825,-0.050132755,-0.0017992021,-0.078457475,0.0028848683,0.0063848076,-0.057879884,-0.010721559,0.0117889205,-3.32817e-33,0.07514201,-0.013707737,0.03152365,0.02820276,0.039535172,0.00640285,-0.054711968,0.018355124,0.001672059,-0.00010966402,0.0011277418,-0.068987474,0.030542957,0.07218505,-0.044678695,-0.009718601,-0.05248554,-0.019933201,0.00880243,-0.060352672,-0.011104944,0.10314233,-0.013219443,0.015595984,-0.0556051,-0.017263832,-0.028166829,0.04312516,0.057431802,-0.015652448,0.023285683,0.0002942187,-0.03603258,-0.012723072,-0.033237245,0.083814874,-0.093497545,-0.0061717615,-0.018450322,0.11822336,0.09806001,-0.021035906,-0.07276049,0.0056809103,0.061438806,-0.03604972,-0.055668816,0.036166575,0.023255618,0.029345801,0.10706012,0.017597884,0.03153072,-0.009769559,-0.062158864,0.047483843,-0.019821642,-0.06055894,-0.063709185,0.044103544,-0.02064126,0.016826699,0.048169527,0.02786801,0.013640968,0.014372017,-0.08984693,-0.052956693,-0.044762466,-0.010425633,-0.0457958,0.024106806,0.097222544,0.020950427,0.020126898,0.0072094165,-0.057380304,0.014220906,0.08063157,0.0096196905,0.020061,-0.037298188,0.05493514,-0.0063767834,-0.07704739,-0.01506274,0.0063002836,-0.13443549,0.0018620183,-0.0046912464,0.10100279,-0.07367561,-0.044243842,-0.025175309,0.009378533,3.640223e-34,0.039447375,-0.091917105,0.04814715,-0.07669379,-0.02521016,0.013160059,0.017939629,-0.013634266,-0.020001495,0.01959283,0.11471446,0.037949763,-0.07307877,0.0053645805,0.00037128475,0.07593914,0.050637726,0.033224594,-0.068583995,0.0024141935,0.02056766,0.022790615,0.056433536,0.15356375,0.06309639,-6.777573e-05,0.012564734,-0.054229658,0.026657272,0.07423995,0.013101296,-0.018793957,-0.06715707,-0.033492785,0.002069876,0.022697356,0.0038939763,-0.0075904895,-0.07607241,-0.07201475,-0.05117801,-0.050956137,0.040363107,0.060959306,0.010160621,0.053270847,-0.01124549,-0.032437716,-0.052278064,-0.0039193877,-0.018445255,-0.0020035186,0.005444399,0.08368702,0.06315584,0.08884303,-0.026430616,-0.045782622,0.029911464,-0.030364286,-0.028269269,0.06638332,-0.043089915,-0.10686225,0.096853085,0.03005462,-0.003240421,0.022147834,0.08681366,-0.04792291,0.12019965,0.03757908,0.041909818,-0.015339551,-0.11588974,-0.12194395,-0.0083469385,-0.10409543,-0.084699914,-0.028210687,-0.06742628,-0.024760412,-0.018823924,-0.0526891,-0.125555,-0.04854335,0.018798497,0.06675134,-0.03397042,0.03444205,-0.050365265,0.046767935,-0.049730875,0.09527405,0.029237641,-2.1322151e-08,0.020054087,-0.08533844,0.026168875,-0.06350791,-0.028679185,0.05360259,0.03775601,0.027770998,0.041385114,-0.032646053,-0.021400424,0.060083352,0.09343704,-0.01558043,0.08360847,-0.054957524,0.002528676,0.013686905,-0.054563522,-0.13152462,-0.12531659,0.0033657346,0.022972846,0.0667013,-0.00447476,-0.04663198,0.035329003,0.11909378,0.029475268,0.008435968,0.053566795,0.023910753,-0.014532433,-0.0039472966,-0.003969763,0.041519444,0.060656425,-0.04887125,-0.049001697,0.05562507,-0.0056978464,0.026249623,-0.008497995,0.056397844,0.024006901,-0.033974852,-0.008281015,0.0874198,0.017552476,-0.05189161,0.025269175,0.017151361,-0.061679404,0.013665118,-0.10718588,-0.03024313,-0.05305734,-0.00483075,0.0497776,0.0041073156,-0.025493123,-0.025401402,0.16153629,0.013461209 +5.3.3.7,"cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. This isomerization could take place either in a direct cis-trans interconversion or by an allylic rearrangement; the enzyme has been shown to catalyse the latter change.",384,0.99999994,-0.07416392,-0.018627306,-0.08544475,0.045906138,0.0070491284,-0.0065885163,-0.027451688,0.03952043,-0.00083107647,-0.061520495,0.099111155,-0.041571263,0.00047227688,-0.043086372,-0.052359316,-0.009817079,0.015302258,0.024335435,-0.02207005,-0.05664963,-0.016206281,-0.0097950455,-0.02677586,0.017854188,0.023959557,-0.029648582,0.008806891,0.023414413,0.03142106,0.008423241,-0.031705324,-0.03774111,0.0051474194,-0.0021885843,0.0048829825,-0.014920487,0.03735882,-0.055972766,0.110963665,0.028542496,0.074038066,0.007515885,0.015504331,-0.026785254,-0.011199269,-0.0002250807,-0.047341336,-0.03007394,-0.04762202,-0.0048476327,-0.017097246,-0.013490235,-0.08035484,0.058766086,-0.0222568,0.009060152,0.044845995,0.030073352,-0.037070263,0.048163287,0.09415743,-0.044856682,-0.0039971424,-0.03380411,0.036806997,-0.06206705,0.054819673,-0.042960357,0.02478921,-0.054976758,-0.07555394,-0.029822318,-0.08534473,-0.0033922251,-0.023935288,-0.023271326,-0.00889244,-0.07150615,0.0389483,-0.01644454,0.04713771,0.09508171,0.10309366,0.004276555,0.014276851,-0.010973983,-0.00955832,0.03521873,0.022062484,0.025785562,0.010525327,0.00035914086,0.030440457,0.0070480225,-0.022231517,0.020065533,-0.052624267,0.034235716,0.0057563093,0.0075438214,0.06565845,0.031419963,-0.0826969,-0.12473857,-0.058899306,0.05796356,-0.018806791,0.027590556,0.009433295,0.099371254,-0.10370809,-0.078197464,0.025720917,-0.016165296,-0.1047821,0.142161,-0.0146106165,0.032902393,0.06400828,0.0016458143,0.015874015,-0.040343013,-0.034062967,0.060639046,-0.020687738,0.0066915117,-0.062461674,-4.005743e-34,-0.036145218,0.12233115,-0.016374063,0.07159661,-0.0075614247,0.043240417,-0.039894465,-0.022082651,-0.10567448,-0.05762762,-0.01983265,-0.023122102,0.009186911,-0.01605847,-0.085641176,-0.07929836,-0.04314836,0.079231955,-0.011840291,-0.0320934,0.020972302,0.07893203,-0.04291168,0.051707037,0.022477672,0.042030122,-0.03477676,-0.009431378,0.014608643,-0.029124772,0.010997709,-0.016108414,-0.057590943,-0.027002862,0.10116446,0.0078005116,0.031442557,-0.07282369,0.0063967863,0.093685105,0.044816017,-0.029679863,-0.016414573,-0.05270531,0.113021284,-0.029286025,-0.09945497,0.08618621,0.015381687,-0.008997369,-0.016059002,0.014814654,-0.008634739,0.012247828,-0.08830209,0.018346969,-0.044090357,0.017806955,0.0696913,-0.062124494,-0.017529953,0.019887367,-0.0051643937,0.029520418,-0.027372833,0.09554234,-0.13369721,-0.02466897,0.015771043,0.12335032,-0.08831314,-0.03940889,0.01761932,0.05446977,0.06455074,-0.030693153,-0.16367632,-0.015405072,0.0032220706,-0.021851417,-0.12696254,0.06791952,0.002700253,-0.0019163118,-0.047438756,-0.0972628,-0.066646285,0.09506354,-0.006641752,0.0015196259,0.099211685,0.014344434,-0.024817493,0.06936982,0.021140965,-7.79528e-34,0.04906702,-0.078052185,-0.016864033,-0.10264895,-0.032425296,-0.008721896,-0.0064904513,-0.11443115,0.03429847,0.0078952145,0.08718142,-0.021495353,0.018896226,-0.03644152,0.0003566342,-0.0041794702,-0.017418439,0.0176801,0.037970416,0.017610315,0.07041324,-0.06860753,0.02525704,0.082731195,-0.072719224,0.0007644054,0.10215666,0.013203682,0.13391796,0.10531028,-0.0520711,-0.11087484,0.012846573,-0.023126185,-0.03009994,0.11293386,-0.042934347,-0.026518693,-0.066276334,0.032936864,-0.0586838,-0.025968207,0.003565433,0.05487631,0.017250823,0.04240756,-0.036368664,-0.013519036,-0.024812924,-0.08692943,0.066465944,0.034144793,-0.018060474,-0.03128877,0.019521857,0.05795439,-0.082063355,-0.009244015,-0.04092321,-0.022906382,-0.01936623,0.0101174405,0.0022209703,-0.009683046,0.019965842,0.02947512,-0.014462483,-0.005986011,0.05443402,-0.044290777,0.12203767,0.06000542,0.01351766,-0.025138412,-0.017094348,-0.11543881,0.007667823,-0.05978851,-0.028951736,0.004335738,-0.08242685,-0.04428629,0.01754733,0.057665966,-0.049687427,-0.0254037,-0.001414064,0.14416568,0.025223078,0.013981943,-0.053848278,0.006941482,0.0053718504,0.042223208,-0.0024354446,-3.8696744e-08,0.04214174,-0.0665947,0.06316555,0.009360152,-0.022047214,0.028678654,0.01853641,-0.0588664,-0.008947622,-0.05204812,0.010047267,0.029018024,0.03526345,0.0014607493,0.12340763,0.04130317,0.004121953,0.07806735,0.010124446,0.04931682,-0.07515387,-0.030552596,-0.005305849,-0.0012487973,-0.020044608,0.015843201,0.07683575,0.06774352,-0.011882903,0.033352744,0.02040665,-0.010443768,0.061300553,0.023915336,-0.04087532,0.055976212,0.0028841025,-0.016403867,-0.010477879,-0.015975367,0.051428303,0.027870541,-0.051163416,0.03170222,0.04312806,0.009821212,0.054577343,-0.0069565526,-0.025962722,-0.014266257,-0.022845125,0.031219123,-0.05837299,0.040365186,0.030766265,0.016255721,-0.041090693,0.0052312287,0.0048099253,0.033737063,0.0074364487,0.06286824,0.1303575,-0.054961763 +5.3.3.8,"The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position. Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C3, which cannot be processed further by the regular enzymes of the beta-oxidation system. This enzyme isomerizes the bond to a trans bond at position C2, which can be processed further. The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers. The enzyme can also catalyse the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.",384,0.99999994,-0.088494405,-0.061962485,-0.06762878,0.042011578,0.027590513,0.022681952,-0.08286223,-0.012312406,0.009189736,-0.014326571,0.041761663,-0.027976042,-0.09434511,-0.028214103,0.04193909,-0.0008691766,-0.042830054,0.025957335,-0.005619697,-0.06578334,-0.0065348702,-0.026699672,-0.015532891,-0.03347359,0.07808765,-0.016995655,0.005271891,-0.03736595,-0.011897325,-0.06658258,-0.016251046,-0.112682514,0.056094807,-0.026838413,-0.01651612,-0.00301649,-0.08602839,-0.09810241,0.033418473,0.004131826,0.05405688,-0.03229083,-0.045894407,0.0014200599,-0.037944403,-0.05527105,-0.0186783,0.04889003,0.040125217,-0.018174732,-0.07408756,-0.09536962,-0.051023748,0.015308099,-0.097996764,0.030051934,0.024417404,0.0130659845,-0.082683496,0.0457386,0.050564166,-0.0024139308,-0.02654989,0.03954992,-0.007908676,-0.047200065,0.005879268,-0.048609924,0.049645834,-0.041005634,-0.045469288,-0.03403192,-0.06409588,-0.017817076,0.02276633,-0.025180418,-0.009042549,-0.008385108,0.03549594,-0.03527021,-0.0088324165,-0.0383969,0.051981706,0.04718564,0.04184372,-0.045614723,-0.025252093,0.005851387,-0.020532079,0.06763165,0.068807244,0.03358134,-0.04243613,0.016308116,-0.015856355,0.022540115,0.053581033,0.03899366,0.024493903,-0.0034451473,0.034328323,0.053398043,-0.06124293,-0.06118414,-0.032734983,0.096463434,-0.047454488,0.0030176418,-0.04766124,0.025222247,-0.018296564,-0.023371086,0.06158734,0.036136147,-0.045703053,0.051258586,0.012587339,-0.08326294,0.035493165,-0.013315934,-0.034853257,-0.028884238,0.05297402,0.023089252,-0.0458246,-0.012124128,-0.07339162,1.30946e-33,0.002510621,0.09708222,-0.03290826,-0.051014695,0.016758136,-0.019870272,-0.09763586,0.049380314,-0.0506451,0.06821702,-0.016070943,-0.055720694,0.04378745,0.026136223,0.04060459,-0.06476657,0.0501679,0.10236574,0.102736175,-0.018456675,-0.02928271,0.032486066,-0.030596823,-0.039128613,0.017515015,0.049864963,0.002919018,0.07141827,0.003391654,0.015673244,0.027500154,-0.05134931,-0.024264999,-0.0032358095,0.0562109,0.05553012,-0.016308311,0.01507629,-0.09416252,0.049297504,0.08859872,0.017182594,-0.012006667,-0.05165376,-0.0023761522,0.013473688,-0.0027790593,0.053718586,0.09086879,-0.0143583175,0.033976056,-0.0010679108,0.09040112,0.0013000708,0.020835971,0.06585819,-0.04793894,-0.012692782,0.022516267,-0.05709592,-0.0043793246,0.046330355,-0.03307807,0.030544607,-0.052462474,0.037451584,-0.08991752,0.004545123,-0.033329498,0.11318781,-0.011425548,0.032346196,0.078458555,-0.03349317,0.030104792,-0.0027445417,-0.07891367,0.00022132139,0.003291181,-0.06508952,-0.038573224,0.029447177,0.03309386,-0.053374454,-0.014294817,-0.015483321,0.007897424,0.075754,0.0704248,0.051621616,0.016029766,-0.026173385,-0.027814886,0.042119935,0.05387669,-2.8362307e-33,0.09560497,-0.08972835,0.018648958,-0.14042158,-0.016969774,0.010423009,-0.048372455,0.008455718,0.04790158,0.0040745307,0.06269295,0.007442797,0.0002533418,-0.09320721,0.015004036,-0.035264585,-0.0075896927,0.021907847,-0.03327024,-0.061687402,0.033717867,-0.023803229,0.0059461934,0.10632088,-0.048963718,0.03763612,-0.00093583146,0.08079819,0.08223491,0.083811305,0.0005069704,-0.061612695,0.012243113,-0.024297955,-0.0077013685,0.07726902,-0.07677226,0.076657265,0.05137704,0.089916945,0.02475439,-0.02333906,-0.015817625,0.0061832187,0.065037444,0.034385867,-0.05574056,-0.10399612,-0.013055083,-0.1661458,0.06783956,-0.040256105,0.002741361,0.052619483,0.0633602,0.13068622,-0.06495316,0.012277885,0.015228573,-0.11067355,-0.0021655604,-0.055044696,0.02088443,-0.0554571,0.018630039,0.025570754,-0.086869285,0.01131967,0.005898899,0.04781873,0.021259144,0.0693517,-0.04673056,0.060509972,0.02581131,-0.06148531,-0.02492349,-0.04559905,-0.062286813,-0.00029610435,-0.021057436,-0.036039647,-0.028384993,-0.060423385,-0.072761185,-0.008860405,0.01751926,0.08793467,0.004267951,0.010689402,-0.02170019,0.05954342,-0.0035875277,0.059401527,0.07483104,-3.758899e-08,0.03586004,-0.04559081,0.05179371,0.04401234,-0.12352725,0.06688504,0.030672198,-0.03250684,0.012522765,-0.06623569,-0.08512172,0.112084426,0.047212455,0.04117707,0.030900616,-0.011063879,-0.107127406,-0.012952929,0.004508184,-0.058290634,-0.055517267,0.050809816,0.056552343,0.018347226,-0.008878759,0.014046814,0.016438441,0.000813499,-0.041975915,0.08306614,-0.026292458,0.052963506,-0.0055610556,0.014934472,0.021009017,-0.008853568,0.047679562,-0.076804765,-0.030108208,0.05384506,0.060964547,-0.042689584,-0.12425834,0.04590777,0.04401979,-0.053003103,0.042287905,0.0638146,-0.010841657,-0.01882064,0.00081465504,0.04108089,-0.1160874,0.01779229,0.010147866,-0.014204893,-0.053074114,-0.013776566,-0.086845815,0.0055295317,0.08869793,-0.04743554,0.17835318,-0.037731126 +5.3.3.9,Interconverts prostaglandin A1 and prostaglandin C1.,384,0.99999994,-0.08997163,-0.051930685,-0.082090475,-0.043435898,-0.02464076,0.0021645913,-0.024857827,0.11411267,0.028096706,-0.0029807426,0.037689064,-0.021603927,-0.011397724,0.02959671,-0.09053257,0.029008977,-0.01697222,0.009237957,-0.05866119,0.0032477304,-0.012253327,-0.023166485,-0.00484752,0.020977072,0.027453793,-0.027161986,0.005268496,0.06781829,0.05494642,0.0110321725,-0.017209549,-0.08250611,-0.008121373,0.005031728,0.029334111,0.056359515,-0.038841426,-0.028382283,0.03465369,0.038701374,0.071023695,-0.025468625,-0.00784516,-0.06712237,-0.024364853,0.005240861,-0.08013862,0.07952713,0.029538931,0.0646674,-0.0071277097,-0.034528952,-0.0883221,0.04660082,0.0074954466,0.028040089,-0.07093092,0.047735427,0.03439697,0.08557009,-0.05768012,-0.015143757,-0.010594484,0.05012044,0.04191658,-0.04935237,0.03797776,0.00276224,-0.05361637,0.046194702,-0.07522237,0.011983467,0.006638506,-0.023355661,0.0492052,0.053901665,-0.08368359,-0.09628878,-0.079546146,-0.11010052,0.09099893,0.086523846,-0.008064026,0.097721174,0.0224127,-0.05668886,0.048524603,-0.002143083,0.0072047277,0.0032940905,0.06524847,0.0020252108,-0.038251776,-0.008197667,-0.011436729,-0.009147543,0.0107848495,-0.03904899,-0.0010743139,0.030433062,-0.07388883,-0.02325685,-0.037853483,-0.104457155,-0.09506847,0.03367671,-0.02618533,0.072016835,-0.0065216706,0.058563784,0.048863415,-0.04031417,0.017687274,0.022451578,-0.0033512407,0.068114884,0.038922504,-0.014697093,0.08375694,-0.036763135,-0.057838045,-0.03951516,0.052119263,0.031284247,-0.104656614,-0.019627163,0.028879989,4.0748637e-33,0.007446892,-0.062023047,-0.0026248402,0.06954047,-0.04025166,0.087155536,-0.07411258,-0.03583339,-0.010912734,0.002065221,-0.07036674,0.05729667,0.0010056886,0.01701109,-0.017001115,-0.011519947,0.11696725,0.02471828,-0.01990052,-0.01963572,0.0177049,0.08786444,-0.047981873,0.0045126034,0.026630597,0.07066671,0.027802808,0.052218013,-0.014044239,-0.018234845,0.006405286,0.02911425,-0.074226916,0.06020363,0.024262397,0.08845431,0.005209805,-0.0719709,0.05601425,0.07207959,-0.030777493,-3.1772986e-05,-0.023966083,-0.07971509,0.10341077,-0.093159206,-0.03575004,0.0735214,0.03667621,0.060232352,0.011698878,0.011542709,0.038487904,-0.04923625,-0.062530234,0.018626723,-0.06822162,-0.010800336,0.032860864,0.09124742,-0.03782135,0.04550468,-0.056769423,0.0034556864,-0.017842902,0.06994016,-0.15987715,-0.0924706,-0.057541218,-0.015904697,-0.04300543,0.021678137,0.098829046,0.025315704,0.046050955,0.040159173,-0.09528639,0.06879468,-0.059048615,-0.029582163,-0.069979176,0.021837322,-0.06217788,0.06792752,-0.12400198,-0.011136563,-0.0140222395,-0.039384052,0.026638178,0.049628727,0.007852811,-0.0049270033,-0.043903206,-0.017839808,0.051112436,-5.277614e-33,0.054544535,-0.03337023,0.026949834,-0.04260227,-0.03941578,0.08430506,0.09614219,-0.14501865,-0.047733277,0.025223302,0.07972152,0.003191506,-0.026810553,-0.049505625,-0.049253996,0.00023600126,-0.017538209,0.032856576,-0.05415119,-0.0036683271,0.055666268,0.05228756,0.04618384,0.024243498,0.032803163,0.02169355,0.029804952,0.060782984,-0.018612344,0.11369611,-0.064159475,0.022933135,-0.05779614,-0.016720016,-0.052389227,0.054361355,-0.017961038,-0.05928429,-0.06397771,-0.06734125,-0.0016633909,0.048812717,0.027748303,0.03829388,0.07600511,0.060047463,-0.013838529,-0.060786728,-0.006201874,-0.04581019,-0.07198753,0.04755151,-0.0051387185,-0.068168834,0.0036553692,0.011887231,0.007986879,-0.024257012,-0.018509127,-0.0051246732,0.054552477,-0.040351022,0.022023914,-0.028371895,0.0685554,0.004150915,0.00020041193,-0.08800953,0.15643951,-0.015915621,0.13034368,-0.017840786,0.07418806,-0.07189832,-0.023211371,-0.016887976,0.021161567,-0.09622679,-0.027031645,-0.044596467,-0.062438514,-0.0068318387,0.007531236,0.033429943,-0.057097282,0.07004739,0.01878421,0.03599367,-0.042746287,0.05426371,-0.030067867,0.117185704,0.0075575216,-0.013161659,0.020216558,-2.2696916e-08,0.087841034,-0.029405596,0.08109926,-0.0334641,-0.0048481054,-0.03180428,-0.024169357,-0.052058313,0.0025098918,-0.017190626,-0.046015393,0.10021129,0.04512979,-0.048298504,-0.0032638994,0.052975442,-0.046848092,-0.055362847,-0.04320659,0.02591014,-0.06255046,-0.044621564,-0.08468535,0.01918687,-0.01365479,-0.05876139,-0.00396652,0.01998368,-0.005085444,0.02552791,0.033909164,-0.009959096,0.042726494,-0.053680923,0.05147938,0.08026405,0.017495263,0.10734524,-0.045759983,-0.053217586,0.0033941818,-0.069400884,0.015566695,0.022878563,0.047921747,-0.0054551004,0.0528092,0.025475048,-0.018860692,0.0428879,-0.05341583,0.041943856,0.0052681724,0.0018473241,-0.03176559,-0.024574298,-0.03981771,0.007363565,-0.0064452873,0.01489104,-0.010495548,0.019048933,0.06265261,-0.05595686 +5.3.3.10,Part of the homoprotocatechuate degradation pathway in Escherichia coli C.,384,0.99999994,-0.010396788,-0.06363586,-0.02757893,0.030708626,0.06706244,0.06100982,-0.019160615,0.048800964,0.034744274,-0.009875971,0.03709345,0.036906403,-0.051546533,0.04585259,0.001458202,-0.019191701,-0.10180733,0.053634472,-0.009062403,-0.08586454,0.06751517,0.0036198017,-0.06976494,-0.0018282535,-0.035043683,-0.0002912783,0.0075587584,-0.05234459,-0.04764,-0.033021636,-0.038220808,-0.022115612,0.040671825,-0.05706491,0.111992925,0.078085,0.043938145,-0.16812626,0.11746765,-0.07141053,0.0013283233,0.0719511,0.01310548,-0.018016651,0.0050620134,-0.0031689857,0.003433843,-0.023024011,0.04089412,-0.09558912,-0.007152515,-0.01626951,-0.017381234,0.0128111215,0.075479515,0.05238624,0.038068064,-0.09080767,0.021266915,0.050859485,-0.01460678,0.03827451,-0.017093342,-0.074836895,0.01952265,-0.08154259,0.07537508,0.012338744,0.008151,0.08814555,-0.11997486,-0.022216585,0.009067209,0.07820811,0.021391632,0.03713837,-0.023393435,-0.045526188,-0.015124942,-0.047663935,0.04291867,-0.048523102,0.08269819,0.025417654,-0.011565476,-0.018333133,0.007128572,-0.0093472935,0.05318349,0.042468738,-0.0042706183,0.016277133,0.045855183,-0.051780496,-0.013774055,0.03177901,0.029827254,-0.00678903,0.007064731,-0.033585496,-0.006960906,0.007837024,0.019818868,-0.07517861,0.0040220637,0.016579574,0.007157965,0.14299712,0.040807508,0.03140111,-0.018171463,-0.025821676,0.02727554,-0.011852557,-0.032302935,0.014312061,0.031698797,0.032908417,-0.090385094,0.009075582,-0.0078386245,-0.038329955,0.03441993,0.02829551,-0.09504382,-0.020813718,0.020866193,-2.039107e-35,0.07324428,-0.016669178,0.0041852123,0.016251374,-0.0074452762,-0.058969952,-0.051513236,-0.059205964,0.023362238,-0.033560704,0.008405762,-0.11460598,-0.061593276,-0.0038475257,-0.037047926,-0.010495846,-0.07511269,0.022245536,0.03269148,0.020965677,-0.024527173,0.10026072,0.02886796,-0.046928838,0.072244264,-0.0076482925,-0.03125566,-0.01603407,-0.035446547,0.006321468,-0.06002889,0.025100216,-0.11832106,0.035295255,0.12982479,-0.057471056,0.03592347,-0.01632569,-0.01857374,0.081596956,0.0029467056,0.045626976,-0.04930743,-0.03980198,0.06308407,0.015872428,0.03193903,0.09461028,-0.033572428,0.06294961,-0.017294357,-0.030280693,0.022325339,0.0056699105,-0.06329104,-0.022499893,0.05075593,-0.06290837,0.06629741,-0.010603213,-0.0020555656,0.07597197,-0.05769831,0.007463661,0.046251826,-0.018153854,-0.049397495,-0.012071982,0.063842,0.06895546,-0.06093726,-0.044720747,0.01189875,0.010121068,0.024406537,-0.05108092,-0.16454023,0.07612289,0.06994324,0.0031711592,0.03740044,0.023914522,-0.027943932,-0.046816632,0.012699875,0.049080983,0.016250871,0.0086980155,-0.022097183,-0.0057618613,0.053860288,-0.030307798,0.006105811,0.03656601,0.023324674,-1.6865607e-33,0.05124297,-0.042702775,0.02164507,0.00016585554,-0.13078737,-0.07608429,-0.02419224,0.046290033,0.04559889,-0.0058678985,0.03371984,-0.013548721,0.022395557,-0.029258702,0.00329821,0.024668477,-0.04305631,0.042574834,-0.07946403,0.0032840662,-0.030489152,-0.05079392,-0.028571164,0.031093266,0.040999964,0.055947207,0.020166514,0.07392481,0.07756462,-0.007539905,0.0018758407,-0.0018621975,-0.06599875,-0.0533838,-0.07229567,-0.0046747928,-0.021171028,0.06559454,0.06378573,-0.062132917,0.05596185,0.06772078,0.020088825,-0.020355588,0.005802597,0.053371742,-0.06215366,0.06506779,0.048854508,-0.015212561,-0.016174098,-0.059969224,-0.056485374,-0.027346103,-0.057779472,-0.013957465,0.078114025,0.034068774,-0.10176394,0.010165612,-0.010157188,0.028758954,0.024849908,0.071458355,0.07082643,-0.0055738967,0.053735908,0.06815761,0.03859263,-0.048217364,0.036422815,0.044162,0.047641013,-0.030010428,0.03936739,-0.052360035,-0.1290554,0.02742703,0.06503736,0.10185777,0.00309777,-0.003307988,-0.035071522,-0.079511024,0.030940358,-0.033597987,-0.042078186,0.117871664,0.074827105,-0.00072466343,0.025047682,-0.10506765,-0.0576559,0.053762432,0.024978083,-2.2532825e-08,-0.016435431,-0.049719635,-0.013041139,-0.06728221,-0.007929012,0.012922017,-0.014135549,0.05274371,0.17131433,0.024201144,-0.049072757,0.05196991,-0.060459152,0.009477981,-0.092332356,0.011491876,-0.06041984,0.00088315713,0.024294673,-0.0017742043,-0.08383535,-0.100799605,-0.035700895,0.02791423,0.05156751,-0.04765961,0.04740276,0.051605098,-0.055533797,-0.047912177,-0.03194442,-0.021684263,-0.04078357,-0.016345706,0.0016839652,-0.021004738,0.05611268,-0.07277155,0.011157886,0.05432339,0.002689498,0.009650659,-0.08954239,-0.020338746,0.08477455,0.056098677,0.01830672,0.060363077,-0.05208412,-0.051419985,0.06736772,-0.061178774,-0.02738587,-0.037296273,-0.067416824,-0.03659243,0.045011267,0.03190574,-0.01990553,-0.036214855,-0.03352744,-0.030335082,0.14618814,-0.020898376 +5.3.3.11,Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves.,384,1.0,-0.0021875587,-0.08837066,-0.11477672,0.05609907,0.0233973,0.114188336,-0.08289144,0.03400974,0.018213343,-0.046211455,0.06975508,-0.024796218,0.013701034,-0.06038976,-0.060945652,-0.065611966,-0.080038115,0.0077988836,-0.0031968853,-0.06951253,0.06151726,-0.0385327,-0.034963895,-0.08557111,-0.017689764,0.072637744,-0.08954699,-0.01638618,0.061867043,-0.07736195,0.048082236,0.050029572,0.07137634,-0.11457141,-0.00082270405,0.020904759,0.0063011204,-0.049232773,0.117125235,-0.020818302,0.023063643,0.032111768,0.02750525,0.0147811165,0.011797596,0.01963214,-0.006048661,-0.034144565,0.030181214,-0.014119011,0.04682944,0.049013004,-0.012656221,0.04057288,0.025878405,-0.020922577,0.0678851,0.006273769,-0.0031503928,0.04501555,0.0033338992,0.0014390106,-0.027077146,0.0016454213,-0.066343874,-0.018294968,-0.084559865,-0.016121432,0.06835237,-0.022407081,0.021898482,-0.054157674,-0.12681739,0.00050861045,-0.058824543,0.064507425,-0.024310475,-0.04601879,-0.10389169,0.041952524,0.026823997,0.057073522,-0.0051095104,0.13297933,-0.0036611222,0.001192213,-0.029488249,0.00074784894,0.04716649,0.09907454,-0.046322003,-0.050994076,-0.0053563025,0.014668928,-0.096117124,0.047405154,0.04370492,0.0187995,-0.1332763,-0.0511786,0.039573304,-0.019632934,-0.12624344,-0.08898021,-0.059757717,0.014874617,-0.0076154172,-0.025529535,0.032593988,-0.02862798,0.003430078,0.016864497,-0.076221675,-0.03692283,-0.044416826,-0.05281866,0.06277509,-0.027286503,-0.06963803,0.006813146,0.008879437,0.040871568,0.015047332,-0.020489862,0.03644272,-0.05554697,-0.0243099,-1.4518415e-34,-0.0018671914,0.018321758,-0.0040233964,-0.03734146,0.0053812196,-0.021096721,0.016086338,0.041001927,0.076441094,-0.09587355,-0.012260719,-0.054695543,-0.08191763,-0.05036526,-0.06850139,0.011138577,0.025951996,-0.059407257,0.070312016,-0.026072249,-0.047326487,0.052412458,-0.06821568,-0.042037264,0.0068831225,-0.0048290617,0.054432306,-0.022473833,0.06705502,-0.020339224,-0.022853868,-0.027065048,0.0289786,0.06588155,0.053720493,-0.0021296258,0.015453774,-0.027995927,-0.021167604,0.041724883,0.014089799,0.046657287,-0.0737558,0.0037766427,0.057547614,0.01666858,-0.044833083,0.08714723,0.09254305,0.023683188,-0.0029471493,0.029150853,0.12883084,0.041937165,-0.034500163,0.030892482,0.00061779225,0.040314645,0.02595711,0.08942027,-0.024065852,-0.02030829,0.00427155,0.022834469,0.066291355,0.07478064,-0.05905366,-0.05247936,0.027665248,0.07977726,-0.060739197,-0.0074865245,0.0032017624,0.01542061,0.10530416,0.030281333,-0.009554157,0.08315419,0.12934537,0.009795646,0.0036242267,0.023652324,0.0069000605,-0.0023054807,-0.030676441,-0.03266529,-0.0076894504,-0.00802577,0.020486401,0.011713922,0.036537427,-0.0063910345,0.023239074,0.07722275,-0.040937185,-1.5832555e-33,-0.023059081,-0.029512282,-0.006694917,-0.008692897,-0.020089766,0.048327122,-0.099452645,0.028239379,-0.010740449,0.043846317,-0.047482435,-0.022456918,-0.013953979,-0.015973186,-0.055279344,-0.028337475,0.085973345,0.10508596,-0.022984536,0.018693577,-0.05072288,0.05909199,-0.0027543546,-0.021005157,0.011611029,0.021012878,0.040121254,-0.016342103,0.012652468,0.06847198,0.11481924,-0.0310986,-0.08911315,-0.018822659,0.012833555,0.06895683,-0.03217389,0.081469715,0.03795753,0.08041732,-0.047134355,0.019221101,0.049455702,-0.020389557,0.12029235,0.0040266146,-0.12054112,0.024974339,-0.012725329,-0.023673493,-0.0113145355,-0.04130344,-0.06710508,0.019514402,0.025620632,-0.06737525,0.0041956934,-0.024230659,0.08768741,-0.072860256,-0.0567658,-0.0027239714,-0.084274344,0.014730062,-0.039044015,-0.025544737,0.021925893,-0.036637902,0.040927213,0.036828846,0.05204233,-0.008729019,0.11894775,0.05858587,0.0049945475,0.035966586,0.018663915,-0.08507755,-0.006921342,-0.028877407,-0.04841893,0.07643606,-0.016719343,-0.0929128,-0.113083325,-0.041522007,0.026882917,0.06714961,0.01696803,0.047534704,-0.0013035135,0.05075443,-0.09627771,0.07044055,0.07780386,-2.277979e-08,0.047037624,-0.058624048,-0.01129316,0.058244176,-0.020415582,-0.037945144,-0.035579555,-0.03732451,0.09070677,-0.013929624,0.03079603,-0.014766652,0.008558537,-0.0015114986,0.010785524,0.02167424,0.05552129,-0.0155844195,0.009652909,0.05188476,-0.032979317,-0.04540821,-0.0055920603,-0.052189372,-0.010379453,-0.106455795,-0.0010811462,-0.03688985,-0.039681025,0.01508078,0.06112084,0.044820774,-0.021218391,-0.07439256,-0.014381755,-0.0016421642,0.025073137,0.0029421982,0.09449076,-0.043008976,-0.055389628,-0.058308154,-0.006397531,0.057577997,-0.0061395895,-0.0253073,0.0146564,0.03797936,0.0039060032,-0.0064807185,0.019350763,-0.047056,0.047537442,-0.09333501,-0.06235056,0.0284596,0.022654135,0.032400463,-0.006227768,-0.11166101,-0.09555862,0.017480258,0.09493255,0.06347568 +5.3.3.12,"A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).",384,1.0,-0.08259157,-0.05354881,-0.021956747,-0.056675456,0.06907317,-0.026443398,-0.06668231,0.059426177,-0.024767064,-0.020654993,0.014545692,-0.06656596,-0.04010097,0.07952968,-0.012810602,0.100381576,-0.023726482,0.05507687,0.02824665,-0.008694961,0.04914393,0.034654494,0.0472579,-0.06428199,0.06025464,-0.018341197,-0.052823856,0.03366729,0.051555336,0.022978516,-0.044681482,0.013690056,0.054088466,-0.031963497,0.0050063278,0.052534826,-0.045410052,-0.00030855372,0.01229701,0.048206985,0.05100323,0.04353815,-0.0005994708,-0.0747831,-0.03671884,0.0052692094,0.007906534,-0.008565637,-0.11130876,-0.005966052,-0.07885807,-0.0674719,-0.023085628,-0.0018582059,-0.041868377,0.026932364,0.0075962734,0.058493707,-0.0025414482,0.03591715,0.024367472,0.033145975,-0.05060367,-0.02272928,0.011486609,0.046402734,-0.09369331,-0.021622201,0.031479873,-0.0126306815,-0.003038396,-0.0982752,-0.03137814,0.058419958,-0.04534494,0.020407423,0.036643375,-0.0038610243,0.05091835,-0.04609545,0.02228323,0.020031035,-0.03380489,0.055233352,0.015566616,0.050370026,-0.06162646,0.105226256,0.00493096,-0.028107412,-0.020955943,0.03915984,-0.11597295,-0.025867907,-0.10094056,0.04963191,-0.03527959,0.03784364,0.031472474,0.045776874,0.08350377,-0.027385741,-0.0014497257,-0.091801316,-0.10200471,-0.05622904,0.056029595,0.042536717,-0.009681202,-0.034185614,0.07629386,0.007593114,0.071087115,0.016437575,-0.042530637,0.019557452,0.07351649,-0.06217266,-0.016082529,-0.027349873,0.0397594,0.007397053,0.07996107,0.011936204,0.01955197,-0.0001288347,-0.08320157,2.2428926e-33,0.039491456,0.012338021,0.036873817,-0.0030064627,0.04835013,0.04375017,-0.031857073,0.095147334,-0.07069735,0.0064221155,-0.045329496,-0.04041261,-0.03500106,0.02913024,-0.05411757,-0.033879925,0.0612866,0.08107693,0.014549937,-0.022883821,0.034479313,0.058599293,-0.048058953,-0.009257639,0.089224674,-0.024249416,-0.031797033,-0.05736919,0.033381052,-0.010278176,0.003227871,-0.101005524,-0.035106786,0.0012883212,0.03156232,0.004984049,-0.14342517,-0.0041703875,-0.031906985,-0.045889955,0.03086772,0.03253492,-0.041251794,0.027054954,0.081031494,-0.023363255,-0.013394781,0.018577715,-3.5608155e-06,-0.023095695,0.08558334,-0.032540005,-0.0053435527,-0.047943626,-0.15550992,0.040304553,-0.058154006,0.031406023,0.056547426,0.049091313,0.008646295,0.04185746,-0.07360537,0.027319988,0.04349367,-0.023864403,-0.07001603,-0.061558656,-0.034557823,0.076822124,-0.0027817232,-0.065642826,0.0490375,0.046125617,0.02455364,-0.04866646,0.007256205,-0.014846442,0.057409693,-0.05804932,0.012332778,-0.015975697,-0.00016409688,-0.015214768,-0.13784781,-0.018438857,0.035900608,-0.05171987,0.00032555382,-0.0068303896,-0.037440613,-0.109479435,-0.07996904,0.006040495,-0.017119257,-3.5584297e-33,0.048803423,-0.04816605,0.05897934,-0.07085183,0.012394204,0.010388291,0.028806545,-0.032144364,0.021907356,-0.029878197,0.08186836,-0.024363574,0.059054676,-0.01152303,0.027200796,0.06035001,-0.033494838,0.055227738,0.05352105,0.018825592,-0.049322076,0.051020373,0.08324378,0.02043825,-0.039446916,0.06206168,0.04278096,0.04761959,0.07017025,0.08883092,-0.079332806,0.03735561,0.006225443,-0.1278845,0.004600859,0.071772724,-0.03149297,-0.013908868,-0.021687625,-0.027737966,-0.04210543,0.019116372,0.025293985,0.09404553,0.009226186,0.03351726,-0.11009702,-0.040284026,-0.040299498,-0.02560188,-0.007837035,0.0081656845,-0.027676923,-0.051196035,0.021254323,0.050062805,0.012367722,-0.00866865,-0.04077132,-0.039012022,-0.043549523,-0.06822695,-0.038974814,0.043361314,0.05196942,0.08425752,0.0023034858,0.061562452,-0.036693554,-0.027635349,0.10828059,0.05688482,-0.016425768,0.017283507,-0.07781079,-0.032158166,-0.015178522,-0.056110807,-0.014486641,0.024233028,0.02361451,0.0029931092,-0.0031604795,0.022144115,-0.013398575,-0.07778892,0.013058759,0.15486835,-0.016618105,0.055966176,-0.01137436,-0.010840559,-0.06466551,0.09408038,0.04786133,-4.171533e-08,0.020661024,-0.052109208,0.03937203,-0.054951984,-0.100195594,-0.021498788,0.04456962,-0.024127392,0.040673975,0.015969738,-0.0011986854,0.008231828,-0.04084845,-0.0011105931,0.06707726,0.025320472,-0.090489626,0.01403019,-0.065445594,0.078013465,-0.0015833885,0.0616591,-0.038616117,0.013622835,0.026655044,-0.09356529,-0.055251025,0.08072126,-0.012553573,-0.008673577,0.036721576,0.06613898,0.053588856,0.02326684,-0.02547922,-0.02868164,-0.066672765,-0.07591379,-0.09517615,0.011613915,0.025601769,-0.00020448503,0.010524451,0.01068158,0.02855133,-0.05892363,0.002597943,0.04157316,0.09945858,0.07498348,-0.0056538987,0.014438989,-0.04308511,-0.0850539,-0.058256835,-0.05416475,-0.04842338,0.0221061,-0.04478278,-0.02268518,0.03796095,0.023276012,0.21538258,-0.05866151 +5.3.3.13,"The enzyme from the red alga Ptilota filicina catalyses the isomerization of skip dienes (methylene-interrupted double bonds) in a broad range of fatty acids and fatty-acid analogues, such as arachidonate and gamma-linolenate, to yield a conjugated triene.",384,0.99999994,-0.10359804,-0.0452877,-0.084597096,0.016042309,-0.058682907,0.060999624,-0.005550724,-0.035477612,0.042100515,0.0048855324,0.10359386,-0.044931944,-0.14448741,-0.06627248,0.032848567,0.026448568,-0.086293675,0.04079541,0.0241229,-0.049437188,0.069378756,0.023377966,-0.0059187743,-0.004273249,-0.043575067,0.0067300587,0.024865443,-0.018482173,0.08186807,-0.07885067,0.0078579215,-0.058197066,-0.036315426,-0.00162732,-0.018330548,0.003576557,-0.018676648,-0.05569966,0.017706014,0.017021608,0.067420326,-0.004159234,-0.0022346464,-0.01171019,-0.027969543,-0.107447,-0.05723617,0.0547363,0.010850292,-0.067034416,-0.054228745,-0.034025975,-0.083299674,0.01196275,0.05019503,0.005481523,0.0056178197,0.010756967,-0.008532982,0.022525903,0.08826411,-0.006489824,-0.045877837,-0.011733954,-0.06744975,-0.036510512,0.02275418,-0.021819014,0.08674185,-0.013191681,-0.05184946,-0.033318814,-0.032491818,0.07457337,-0.016094208,0.033740114,-0.000683942,-0.06290389,-0.08521412,-0.012551036,-0.019936305,-0.07947048,0.052112997,0.13570462,0.06962844,0.004500501,-0.044465665,0.05223729,0.023183584,-0.01748726,0.05912567,0.0659938,-0.036027215,0.019387783,-0.048648626,0.07092018,0.050292537,0.0017485595,-0.0045708823,0.037997242,0.08987516,0.039423294,-0.091522574,-0.07055788,-0.055105407,0.006270186,0.03979563,0.034595776,0.029331967,0.024452832,-0.036733694,0.043825023,0.05862764,0.02488407,-0.14440946,0.020834003,-0.004696222,-0.14377351,0.09823516,-0.02900905,-0.060163442,0.041303907,0.026504546,0.0947319,0.03430687,-0.074478745,-0.048804432,1.5440352e-33,0.025846858,0.097219914,-0.0024977631,-0.04030642,-0.04226864,-0.03441797,-0.06912266,-0.032755222,-0.060118437,-0.019615548,-0.061244056,-0.06585175,-0.027172577,0.01248483,-0.01878611,-0.067247175,0.032242805,0.066683225,0.05649973,-0.045034874,-0.04246488,0.06083745,-0.026055714,-0.023345144,0.042993594,0.051480584,-0.003676752,-0.009894653,0.04836509,0.014060861,-0.038462084,-0.021184038,0.010935375,0.021630237,0.026544131,0.032114107,-0.06695729,-0.024962116,-0.046578605,0.08115692,0.059427407,0.022577504,-0.029364178,0.020022696,0.007894606,-0.0364279,0.026351253,0.076689266,0.03956445,0.016197346,0.03660634,0.004688986,0.023921661,0.042849384,-0.13080025,-0.011709086,-0.0755576,-0.06475428,-0.0128175495,0.03441385,0.006360453,0.021399558,-0.018121418,0.04854505,-0.029195255,-0.0026844305,-0.060408078,-0.02906171,0.044993628,0.06473764,-0.033471968,-0.05825417,0.0771885,-0.0043461826,0.07281831,0.002747093,-0.067609705,-0.050401572,-0.016895618,-0.024183368,0.013547893,-0.03598431,0.0027384888,-0.041090738,-0.0703319,0.026259765,-0.031370927,0.035110533,0.026504658,4.010187e-05,0.071183205,-0.004894065,-0.05770484,-0.0049024983,0.032580804,-2.2950462e-33,0.02914687,-0.06383985,-0.0040961886,-0.08069881,0.013176861,0.0109232245,-0.021637069,-0.067198664,0.06627341,-0.048519515,0.117411695,-0.018276438,0.0510693,-0.04402961,-0.0650143,0.0363824,0.063481614,-0.004798796,0.012009781,-0.092228845,-0.013570064,0.002500715,-0.018450202,0.13184127,-0.021425126,0.060675777,0.020083511,0.045596734,0.07175263,0.04064587,0.10476004,-0.060170762,-0.0044851424,-0.027451098,0.0037974978,0.10361481,-0.018476857,0.1246594,-0.03351929,0.039026123,0.041471038,-0.024095092,0.008932093,-0.012927007,0.06107034,0.049610607,-0.0122385835,-0.020518575,-0.108598255,-0.07404584,0.077947624,0.019129593,0.011099088,-0.0015570536,0.06845211,0.0313206,-0.049839344,-0.040179275,0.011909956,0.0053424845,-0.026955804,-0.06843964,0.050024558,-0.08318341,0.055714857,0.030590026,0.0075560953,0.044882383,-0.05663989,0.06683628,0.07751169,0.12480114,-0.07960992,0.062383916,-0.044639677,-0.032697964,-0.0010510121,-0.1123891,-0.059252024,-0.07043528,0.009992859,-0.058071684,0.044481453,-0.05466785,-0.08124922,0.0055901236,-0.007074042,0.061635513,-0.034919973,0.031550314,-0.046458032,0.015515109,0.005635436,0.024498915,0.010893595,-3.540329e-08,0.025113683,-0.025472477,-0.06250088,0.074733794,-0.095065795,0.05288909,0.020671241,-0.0013565887,0.003174552,-0.049374763,-0.07415843,0.0306446,0.08877344,0.047196224,0.009866219,0.02927959,-0.024231285,0.031407997,0.003022668,-0.033217557,-0.043414675,0.04927643,-0.09599625,-0.0688985,-0.014501366,0.011399154,0.04178773,0.045447666,0.07336614,0.018518431,0.021259727,0.037444234,0.014912934,0.024671672,-0.0050769346,0.057436295,0.06957976,0.0050925147,-0.005679071,0.007531375,0.029607225,-0.0045328853,-0.032189254,0.045125827,-0.0037641071,-0.010451623,0.02086969,0.019181393,0.049061596,0.01958047,0.08003823,0.029787516,-0.005788327,0.005477136,-0.057476245,-0.044095036,-0.06505869,0.035059594,-0.05848427,-0.03176054,0.068113014,-0.06198474,0.14244582,0.057008315 +5.3.4.1,Needs reducing agents or partly reduced enzyme; the reaction depends on sulfhydryl-disulfide interchange.,384,1.0,-0.055372432,0.00016270299,0.0022343313,-0.009531643,0.0287463,-0.03512657,-0.065045744,0.06256783,0.06218602,-0.034213796,0.030213332,0.03752536,-0.06257985,0.05794497,-0.03176104,0.08652534,0.016482133,0.09116647,-0.061695684,-0.039143704,0.057534844,-0.083689176,-0.0076526017,0.02164836,-0.017756572,0.039191384,0.04439054,0.02252304,-0.024384962,-0.058172036,0.028046738,0.011953088,-0.028056635,-0.06590208,-0.07492322,0.117398135,-0.056885123,-0.026262382,-0.009106209,-0.0036097239,0.038464352,-0.002858558,-0.062340073,0.003899985,-0.017448053,-0.012817215,-0.048513412,0.015436758,0.029620467,-0.047488246,-0.06512487,0.02101472,-0.04330756,0.01924986,0.004004626,-0.0037296943,-0.101104654,0.038624436,-0.014802548,0.005985767,0.0017446557,0.027991863,-0.060345188,-0.009959942,0.023591476,-0.019164737,0.045950707,-0.023658013,0.031231547,0.009446241,-0.06571438,0.0014478227,0.022056073,-0.0014541809,0.031589683,0.0059087886,-0.023812322,-0.03085432,0.0804162,0.011909684,0.009928284,0.045833863,0.0036259976,0.06706411,0.05381208,0.012925023,0.00077029143,-0.08187908,-0.0016564904,-0.051601063,0.021743482,0.03257553,0.013055415,0.0054538627,-0.051443096,0.031891555,-0.0034825183,0.08303312,-0.04353551,0.03581787,-0.0112732835,0.015491704,-0.10531367,-0.11298487,-0.09030816,0.0018751216,0.02506092,0.0786373,-0.041763548,-0.004093479,-0.002306665,0.023922723,0.033688594,0.049648635,-0.060267787,0.12370415,0.09228078,-0.077275395,-0.06765049,0.013255355,0.019194296,-0.0032571312,0.03620128,0.058795087,-0.058838602,0.052154154,-0.08253096,1.8850417e-33,0.03291945,0.05304834,0.054204386,-0.0022680159,-0.008131905,-0.003275335,-0.11193987,-0.0037085211,-0.0010226053,-0.04409603,-0.026331251,-0.06456777,-0.0112841865,-0.00088389637,-0.014118706,-0.09035915,0.054261338,0.070780545,0.07534664,-0.02062507,0.0033821897,0.058175102,-0.048795525,0.03150124,0.06234168,0.016397815,-0.001167748,-0.0013997826,0.019990297,-0.012817125,0.065480925,-0.04230541,-0.06860225,0.007901959,-0.0032796625,0.053981535,-0.10600391,-0.0221402,-0.0007562761,-0.035182733,-0.0370725,0.06368194,0.009817721,-0.033594586,0.09280666,-0.09205196,-0.019227147,0.07358856,0.023436897,0.035303462,0.078667685,0.02797171,0.07916692,-0.04672739,-0.011314303,0.018631164,0.023194408,-0.05372842,0.030882364,0.08441862,-0.017471027,0.05079973,-0.07204042,0.0058103506,0.031987667,0.021034738,-0.0254498,-0.044033095,-0.08079553,0.029810542,-0.080841765,-0.029480783,0.054985706,0.05402562,-0.01906303,-0.058049284,-0.012357131,-0.022714976,0.048458744,-0.034102526,-0.038280495,0.0083551165,-0.008571131,-0.008009664,-0.046917494,-0.07466013,-0.043686192,0.01400709,0.035307635,0.0061225384,0.034015365,-0.076902136,-0.10118147,0.02984861,0.063205205,-2.3358684e-33,0.05574342,-0.08094541,-0.013057631,0.0019411232,-0.06443977,0.080169275,0.10031711,-0.052785896,0.10009742,0.032960366,0.052267972,-0.038084753,-0.010556574,-0.031091163,-0.073654726,0.10161393,-0.018275676,-0.0069373026,-0.019968024,-0.025536628,-0.025827622,0.2205635,0.06260088,0.024015728,0.04038436,0.004545188,0.022446314,0.08861767,0.06398815,0.015762111,-0.018139001,-0.08131777,-0.079451315,-0.07294085,-0.016973067,0.016916394,-0.06709251,0.015001079,-0.028688386,0.0049121967,-0.009869612,-0.05001056,0.0037503985,0.13970311,0.021985078,0.03628042,-0.047076255,-0.023818072,0.059805647,-0.049489938,0.035647523,0.0046706023,-0.03467367,0.05077983,0.04689338,0.009826882,0.037537284,-0.0766667,-0.066649735,-0.023990253,-0.014963431,-0.049951117,0.03102346,-0.07206107,0.029270342,0.055136967,-0.05758239,0.08065212,0.11797602,-0.06821922,0.10020004,-0.011855823,0.046002656,-0.027237779,0.01917791,-0.03617444,-0.073156044,-0.0021857754,-0.013503565,0.036051262,-0.05693544,0.0047494196,-0.026816491,-0.0863598,-0.014239253,-0.045725413,-0.013804317,0.08461428,-0.007737065,0.08892143,0.008857518,-0.015292412,0.010827453,0.07035585,-0.0073131714,-2.7326639e-08,0.018395243,-0.037364088,0.099392936,-0.018944884,-0.08588695,-0.039405327,0.026665006,0.05373004,-0.016589167,0.019277688,-0.045642123,0.13353017,0.03436065,0.035737466,0.054971218,9.3099225e-05,-0.02785582,-0.001850658,-0.061417956,-0.10799759,-0.053276762,-0.0128332125,-0.11720004,0.065867566,0.08177187,-0.0659174,0.07457384,-0.03097689,-0.050664112,-0.01274711,0.05566542,0.021100294,-0.025600577,-0.022873927,-0.0061119976,0.06937799,-0.025296073,0.015439238,0.0065728645,0.020397848,-0.06280967,0.005242138,-0.044013962,0.069349095,0.053150676,0.0045126462,0.017358327,-0.001100459,-0.002777504,0.03450695,0.058426235,0.010569533,-0.013851357,-0.061657075,-0.07924427,0.022375256,0.045401044,-0.031187262,0.04567968,-0.08178254,0.029955605,-0.05994622,0.12394045,-0.014632757 +5.3.99.2,Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.,384,0.99999994,-0.021783816,-0.04538348,-0.080648616,0.011297072,0.017929,0.012357762,-0.03337953,0.068148874,0.017286364,0.013743688,0.058125675,-0.013546099,-0.05382377,0.06031826,-0.015790677,0.015362626,-0.07227747,-0.03290353,-0.06304854,0.0043976037,0.039663177,-0.015562059,-0.0016777335,-0.011469783,-0.03920816,0.02133694,0.025801932,0.0116326,-0.025370013,-0.086570464,-0.05181335,-0.020736877,-0.014529291,-0.021466896,0.048626933,0.12080598,-0.0478204,0.028869368,-0.0071947044,-0.055454325,0.027276605,-0.037344623,0.027092997,-0.018167425,0.01874901,-0.010162715,0.037958898,-0.02451816,0.022811184,-0.020858098,0.009380206,-0.013194956,0.02368915,0.008054099,0.019444596,0.029580854,-0.03950866,-0.063788414,-0.07260987,0.043045707,-0.00063203555,-0.046817243,-0.05591015,0.0069515216,0.010441725,-0.06927863,0.03611092,0.0026840924,-0.06433282,-0.020807024,-0.006681477,-0.03420311,-0.06750141,0.034232594,0.028381525,0.010142591,-0.07533994,-0.025049279,0.053812034,0.07397361,0.042285696,-0.014151542,0.0033653828,0.10996903,0.0319518,0.03178571,0.031953275,-0.02712176,-0.016782222,0.01124513,0.037699487,-0.011003052,-0.07071841,0.031647842,0.010564456,0.03328608,-0.036904912,-0.018630449,-0.03442859,-0.019180829,-0.039268065,0.027746428,0.012708657,-0.02919992,-0.05346205,-0.0139647955,0.028488252,0.122012645,0.020077528,-0.022457153,-0.0020808422,-0.061810218,0.09602315,0.050136477,-0.014223354,0.09919454,0.052081574,-0.06694009,-0.014179284,0.04219027,-0.022105388,0.05199119,-0.007782526,0.01760708,-0.07540991,0.017291551,0.009716923,-6.1838414e-34,0.07941892,0.034701917,0.0042391242,-0.04649689,0.05226132,0.089296974,-0.11848105,-0.025485555,0.012441635,-0.06605812,-0.118193954,-0.013814863,-0.006421889,-0.025552884,-0.047943294,0.006825405,-0.093923904,0.024226755,0.03550192,-0.038719162,0.04135827,-0.045381017,-0.06719855,0.0049100234,-0.03676048,0.063264236,0.014810394,-0.048938386,0.026682813,0.011418764,-0.0026632408,-0.024939815,-0.05945402,0.045096286,0.015431452,0.08953393,0.016786125,-0.027751192,-0.04754801,-0.0032437884,-0.024242004,0.006688337,-0.049581636,-0.030380508,0.07520114,-0.14211015,-0.0742452,0.10447728,-0.008339419,0.15260163,0.04862873,0.027731098,0.072513394,0.043825515,-0.085452825,0.048451804,-0.031300955,-0.040430114,-0.00079321914,0.014395827,-0.03674775,0.12724006,-0.06263505,0.03968589,0.016176183,0.077827804,-0.053857032,0.00663111,-0.06641383,0.1034833,-0.07425566,-0.09400676,-0.05552695,0.08023159,-0.055088963,-0.004921349,-0.10907645,0.07173367,0.078159705,0.002608181,-0.024653599,-0.0029366629,0.017511586,0.0762616,-0.04721734,-0.024608064,0.0052742367,-0.02869174,0.009144738,0.04293317,0.08117576,-0.05312162,-0.008412685,0.06435831,0.031098709,-1.3344796e-33,0.13431521,-0.08926384,0.08493491,-0.059234213,0.08370881,0.06357467,0.022159584,-0.037502803,0.07780325,0.023451399,0.06305202,0.023364719,-0.009883088,-0.03360105,0.04581341,-0.058767673,0.0019849727,0.064866,0.009947272,0.03175113,0.018269861,0.07823627,-0.010001532,0.044158682,0.07387427,-0.002727482,0.019233681,0.005207604,0.0019263196,0.008956961,-0.036455743,-0.02737159,-0.06643433,-0.046316564,-0.017567774,0.05979707,-0.014296613,0.0033667258,0.006088158,-0.048751432,0.023036296,0.023186103,0.008569437,0.055785663,0.0308433,0.09628792,-0.11635415,-0.014839841,-0.047133088,-0.043212898,-0.035980128,0.08998236,-0.013157702,-0.039866213,0.034223467,0.0037620873,0.02170209,-0.048388656,-0.06954022,-0.0034450043,-0.015852962,-0.03286959,-0.061372213,0.008791137,-0.009827435,-0.04863864,-0.0043461476,0.007415596,-0.00526474,-0.017878536,0.04535301,-0.05969317,0.048458256,0.03344292,0.00508183,0.00935927,-0.06190339,-0.031667598,0.038195882,-0.03827065,0.0054706982,0.053169753,0.047808148,-0.03902044,0.02957972,-0.10142989,-0.012916723,0.044489115,0.0043919436,0.06967094,-0.05403111,-0.004903546,-0.05370298,0.0054134326,0.03884326,-2.3747662e-08,0.026059264,-0.027453827,0.09674471,-0.05581089,-0.05205082,0.030724255,0.07551472,0.08528976,0.044344276,-0.06111912,0.040809684,0.15105982,-0.016651154,0.047107477,0.013556473,0.0232297,0.00612814,-0.00875873,-0.03660146,-0.043253593,-0.17469712,-0.043742113,-0.0071559153,-0.0015147257,-0.027481463,-0.059598267,-0.019457106,0.019274274,-0.05954233,0.03215021,0.03672316,-0.010519527,0.034676224,0.011439129,-0.12873401,0.10418059,0.050243896,-0.0103540085,-0.080598004,-0.058667246,-0.023334539,-0.01666854,-0.014022459,-0.031912062,0.015762134,0.022535536,0.030592,0.057235945,-0.030630972,-0.005557229,0.051219277,-0.046807047,0.017416634,-0.07376073,-0.10376169,0.087931395,0.0055375756,-0.079049535,-0.031957105,-0.051259387,0.0030714744,0.060211696,0.1719857,0.015615463 +5.3.99.3,Brings about the opening of the epidioxy bridge. Requires glutathione.,384,1.0,-0.014144169,0.0019788444,-0.035096906,0.01998599,0.0036188683,-0.004149713,-0.0019569667,0.07310947,-0.0086498875,-0.007410346,0.065544985,-0.0018362465,-0.039588198,0.055004753,-0.013466446,0.009910565,-0.0093809385,-0.018193202,-0.054398708,0.041192703,0.02034586,-0.019601194,0.030366678,0.002256351,-0.07714647,0.052789725,-0.00039895007,0.06692773,-0.006317811,-0.09293393,-0.04090328,0.010107504,-0.056018468,-0.046194345,0.023103837,0.07886666,-0.054307543,0.059112154,-0.012483047,-0.055763654,0.035631984,-0.05445742,0.058540117,0.011189676,0.05129609,0.00495415,0.014993235,-0.012103879,0.047064427,-0.027921822,0.041295245,0.0047438093,0.039348394,0.014690143,0.028684096,0.0054419963,-0.0665113,-0.06810046,-0.04521966,0.05386286,0.010229756,-0.033689864,-0.09684578,0.016029356,0.004518493,-0.063938,0.016927276,-0.010655297,-0.06042622,0.007022628,0.031192133,-0.0010781618,-0.04895245,0.019422717,0.017527485,0.018329268,-0.071494386,-0.021768115,0.06427634,0.102326274,0.023687338,-0.0001558998,-0.013804216,0.121834725,0.056517664,0.05017412,0.03859114,-0.04538272,-0.04411721,0.00043059938,0.01623187,-0.00036429617,-0.070279814,0.05883578,-0.0072858552,0.03225591,-0.06870049,-0.025333364,-0.06735913,0.016683012,-0.026504304,0.03005191,-0.009821045,-0.025730245,-0.060860906,-0.033297904,0.025778528,0.099479474,0.008485705,-0.034757767,-0.026754688,-0.072067425,0.07049802,0.050447874,-0.04503533,0.09381216,0.0560191,-0.05436723,0.001953508,0.017363973,0.0046073305,0.042512923,-0.039814517,0.009381894,-0.07224533,-0.021385787,0.049161147,-4.8594234e-34,0.048607204,0.024247348,0.0028796473,-0.02831088,0.06522058,0.092638716,-0.13353628,-0.057095252,-0.0091668,-0.058063153,-0.12517624,-0.0071220896,-0.048931573,-0.009242783,-0.045471527,-0.0322015,-0.11571297,0.050230473,0.025927385,-0.0695224,0.05567217,-0.027211342,-0.057799753,0.008187761,-0.04177085,0.06292886,0.035965223,-0.063244864,0.034820482,0.033573195,-0.0045708613,0.022536108,-0.038477335,0.036778893,-0.038092796,0.08908276,-0.034028474,-0.061387043,-0.06518183,0.011240823,-0.023124862,0.030367844,-0.05666109,0.019009583,0.07604693,-0.14006983,-0.03616096,0.086745515,-0.014711057,0.14100014,0.038694188,0.046373136,0.022295179,0.06093038,-0.07894266,0.045188557,-0.010084787,-0.045656614,0.0073963148,0.008004623,-0.04760998,0.12116138,-0.044199105,0.017000338,0.034237493,0.08092529,-0.05144212,0.0162035,-0.080676846,0.027220104,-0.04509035,-0.09952186,-0.036872417,0.09802774,-0.08177153,0.006067134,-0.086295225,0.08198739,0.08999434,-0.0337276,-0.031057985,-0.0041890554,0.022844752,0.107546695,-0.042131428,-0.029709829,0.035988376,-0.039145384,0.015040417,0.035070144,0.0789347,-0.062154047,0.019318577,0.02500108,0.012431825,-5.4570117e-34,0.079862624,-0.0614639,0.0866429,-0.025089104,0.1132988,0.044785067,0.010569699,-0.03708097,0.08543528,0.03831506,0.053633943,0.05458394,-0.0023765848,-0.016752452,0.049199656,-0.0522912,0.03163266,0.029558351,-0.025850803,0.053796496,0.040876664,0.08583859,-0.014093835,0.053345427,0.045233544,0.010157243,0.028443014,-0.037441034,-0.011536565,0.021689907,-0.04516203,-0.025840394,-0.08635846,-0.053163733,-0.019249331,0.05882152,0.028004901,0.0015962522,-0.036331847,-0.075055316,0.032197718,0.0046028164,-0.0103301,0.06783505,0.017452493,0.054848764,-0.06835867,-0.02446453,-0.043703027,-0.0022851422,-0.04202153,0.07413069,-0.021925062,-0.052279726,0.033334058,-0.015802057,0.020405702,-0.082668595,-0.08119799,0.010011181,0.004771355,-0.0047547584,-0.09012332,-0.016712468,0.027214505,-0.05372875,0.01630657,0.004277982,-0.0054919207,-0.025538849,0.037673842,-0.04698703,0.05594096,0.007387806,0.03601678,-0.01846552,-0.0130909495,-0.029446704,0.024362782,-0.03041033,0.014837049,-0.003267267,0.037349213,-0.030659657,0.0548897,-0.10085182,-0.02477503,0.01909404,-0.0016077261,0.102585986,-0.052851364,0.022957984,-0.02896233,0.024423499,0.029585851,-2.241498e-08,0.0097987475,-0.0112076625,0.08366815,-0.044195816,-0.06497385,0.017086133,0.0800235,0.071798995,0.0070229988,-0.083235234,0.084891036,0.16598941,0.02238794,0.05259351,-0.015482883,0.013620073,0.025991656,0.016567264,-0.06404537,-0.052180726,-0.17974277,-0.041768692,0.03397483,-0.041843757,-0.03204185,-0.027030861,0.0064430777,0.0003411367,-0.04426698,0.036695864,0.04205466,-0.01503868,0.018402237,0.033919007,-0.12154177,0.11896131,0.031533852,0.01495055,-0.07879586,-0.08027881,-0.03075113,0.010454088,0.00083612953,0.013851745,0.0059619388,0.0047419104,0.006310097,0.05647717,-0.050886825,0.017684162,0.041912843,-0.03980634,0.041243054,-0.064338624,-0.08168668,0.06972904,-0.007709921,-0.05335648,-0.020212628,-0.046537846,0.0007988146,0.031561922,0.11565388,0.07924768 +5.3.99.4,A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).,384,1.0,-0.10513816,0.08464424,-0.07776044,-0.03501641,0.046189126,0.015607328,-0.005836673,0.14686409,-0.011836385,0.041859042,-0.034702655,-0.03987568,-0.04217605,0.027288787,-0.03420718,0.030645007,-0.020643735,0.009714419,0.0016916648,-0.11289039,0.012795409,0.010347592,0.024608806,0.041613877,-0.023090815,-0.0037730834,0.02007767,0.08622646,-0.019805295,0.02034173,-0.039192654,-0.10589331,-0.008580553,0.015049586,0.022527797,0.13722801,-0.090179116,-0.022301095,-0.022689508,-0.040733162,0.09518092,-0.061784804,-0.11295274,0.016248714,-0.019702246,-0.033616703,-0.02451207,0.045462884,-0.017168429,0.052392513,-0.028571391,-0.0016580612,-0.06958585,0.008456101,-0.02704133,0.018538577,0.010469319,0.021374634,0.0064901863,0.01882495,-0.03565998,-0.0006303623,-0.033317253,0.05427078,0.029820604,-0.06148093,0.009359793,-0.00072646217,-0.055408243,-0.07434773,-0.04068297,-0.023504242,-0.03910331,0.013567337,-0.020811876,0.01836081,-0.07646421,-0.032558188,-0.020885678,-0.05126725,0.07504667,0.013543092,0.0268672,0.11093515,0.018598197,-0.002549341,0.010387368,0.048695687,-0.05117137,-0.04318801,-0.02876755,-0.024954546,-0.010430168,0.0044180383,-0.08807348,0.04638738,-0.003319157,0.008876973,0.04247469,0.0064755846,-0.004170902,0.065214,-0.032928914,-0.17774542,-0.082462266,0.005227567,-0.025183702,0.07575026,0.07865614,-0.015704272,-0.020457437,-0.01667495,0.00435842,0.0037032447,0.012831658,0.13460614,-0.029773373,0.042732097,0.015331229,-0.002109485,-0.026223224,0.014405699,0.012457654,0.0098066805,-0.073652245,0.011074555,-0.046187196,5.6091e-33,0.062784694,0.038062617,0.027057266,0.054826,-0.048878178,0.0009106367,-0.11078692,-0.0013778093,-0.011269691,0.009870099,-0.05873917,-0.059782375,-0.019929146,0.0062437225,0.006336145,-0.06267356,0.005170104,0.023184717,0.020434367,-0.0072319107,-0.034729548,0.07171387,-0.037986714,0.0017444089,0.03091121,0.15031818,0.012115453,0.042437438,0.02450492,-0.00492533,-0.0018098669,-0.07126514,-0.06704298,-0.012912105,0.01769952,-0.0010075974,-0.022329055,-0.033290837,-0.0023073547,0.036436707,-0.054214142,-0.06168009,0.029733242,-0.056385048,0.08480587,-0.052740276,-0.055288848,0.033959765,0.006543084,0.028482912,0.031221736,-0.079494774,0.10390959,0.0490922,-0.08657771,0.024124831,0.028968005,0.019574605,0.02525616,0.07105616,0.094903655,0.08280559,-0.015379267,0.07354981,0.0290277,0.030727385,-0.07290175,-0.03906114,-0.068822674,0.115378395,-0.020819986,0.062082887,0.11124287,0.016322033,0.05862702,-0.004791982,-0.0016154535,0.03909068,-0.0074699023,-0.018134313,-0.027573943,-0.027831856,-0.020069322,-0.0044486965,-0.012568005,-0.06008485,0.016991822,-0.05847372,-0.017862406,0.05677731,0.017421655,-0.07617959,-0.0019500264,-0.015748313,0.012470322,-6.389709e-33,0.06251679,-0.037573073,0.08029369,-0.082470424,-0.042947214,0.05999992,0.032016672,-0.05492946,-0.053007476,0.026788112,0.11348666,-0.045760468,0.009373458,0.009724173,-0.042047527,-0.03662323,-0.037957866,-0.01811589,-0.026960703,0.027278122,0.051908594,0.015156449,0.015341306,-0.004960839,0.0715821,0.044043075,0.08936573,0.054681394,0.05963053,0.066407986,-0.077203535,0.0058780727,-0.11238056,-0.062787816,-0.05065733,0.07030752,0.03598563,-0.028865227,-0.042165518,-0.015172504,-0.069100365,0.028995305,0.04974386,0.040798873,0.03812911,0.1442745,-0.02067902,-0.018543614,-0.04094161,-0.073028624,-0.008692956,0.06166357,-0.042859502,0.015541272,-0.014376343,-0.008696026,-0.02468241,-0.04984158,-0.024063423,-0.06906039,-0.03308314,-0.03758234,-0.0005967147,0.06737464,-0.024604186,0.03192746,0.009402605,-0.05369842,0.036312047,0.022691103,0.097436145,-0.035582572,0.044327073,0.030204087,-0.015684187,-0.020137921,0.012750294,-0.027677305,0.04925754,-0.06789731,0.047876425,-0.017776184,-0.037430782,-0.054911084,0.015053242,-0.094485566,-0.046441756,0.06902548,-0.0064882836,-0.020258497,-0.026268955,0.17357016,-0.027283615,0.015673334,0.018494215,-3.2702264e-08,0.017562637,-0.0912448,0.08750802,-0.02497496,0.016285865,-0.028115068,-0.00088786875,-0.013678838,0.022343816,-0.053766012,-0.06938891,0.0687758,0.027673874,-0.08163762,0.022011455,0.07754467,0.041655604,0.006801709,0.037456155,0.0033832123,-0.06931789,-0.03369075,-0.07050467,0.010271046,0.0030700073,-0.08731346,-0.016159434,0.005933843,0.050871138,-0.0014330028,0.026899913,0.06170373,-0.0058665657,-0.017754223,0.08088554,0.05142942,-0.058499817,0.015310379,-0.0105690705,-0.07892991,0.010863556,-0.03232085,-0.04759226,0.009932868,-0.00438845,-0.012358201,0.1013297,0.03621724,-0.0046040695,-0.011210295,-0.068927005,-0.0010638399,0.0009976462,-0.07259161,-0.09427177,0.054920733,0.060773924,-0.042201575,-0.042017326,-0.051707387,0.062657274,0.03041066,0.16582972,-0.034670472 +5.3.99.5,A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2.,384,0.99999994,-0.06815443,0.039357163,-0.107908055,-0.034249935,0.048254885,0.031061335,-0.047274202,0.15618381,0.0018526859,0.01683842,-0.040264115,-0.01962061,-0.098579496,-0.001708829,-0.0076631117,0.030163892,0.009546191,-0.009373962,0.030529445,-0.1548562,0.00036118293,-0.0036893196,0.028851043,0.03314416,-0.029676368,-0.0046143327,-0.025592407,0.07745506,-0.028921895,0.009606985,-0.042264383,-0.080693536,-0.021822542,0.023165734,0.009613314,0.11895319,-0.12800488,-0.012369269,-0.037435684,-0.036807526,0.08657245,-0.05580592,-0.13474846,-0.0041971887,-0.046297412,-0.043353558,-0.040642157,0.06807027,-0.011119442,0.04664459,0.0011002078,0.0024587861,-0.0609264,-0.021456784,-0.041689534,0.027785325,-0.008064263,0.007791419,0.04332297,0.02606703,-0.050595235,0.067635484,-0.034788396,0.045736972,0.05191664,-0.053765755,0.03326592,0.03380062,-0.030494958,-0.038043026,-0.032565366,-0.008018151,-0.012379737,-0.0065791854,-0.006738446,-0.009877131,-0.056830015,-0.048321147,-0.011631506,-0.024776476,0.03823703,0.037104517,0.018850489,0.10483846,0.024224073,0.005445877,-0.0076057804,0.070968926,-0.07340606,-0.060573246,0.012781439,0.007076358,0.010986935,0.030629314,-0.06686008,0.06831715,-0.00079374487,0.0063504954,0.02200288,0.005591213,0.013743742,0.05935873,-0.05640654,-0.1545433,-0.044270795,-0.010742845,0.003131274,0.091924496,0.08448532,-0.016001496,0.012906218,-0.048438348,0.03467115,0.013054062,0.019413875,0.0980336,-0.05248123,0.037867226,-0.0039617824,0.023222346,0.01290236,0.00855944,-0.00800755,-0.008375998,-0.05795058,0.016766064,-0.04986997,4.4788693e-33,0.076661654,0.0475758,0.02884417,0.045813423,-0.0015794421,0.040801972,-0.1072686,0.02848116,0.0029109705,0.082032174,-0.021250704,-0.069904566,-0.03588144,0.004184338,-0.017808251,-0.07502096,-0.01584177,0.03968295,0.037527133,0.01023891,-0.047406748,0.06391336,-0.029099895,0.044115026,0.0032472028,0.12119109,-0.007315235,0.067874454,0.024202349,0.017680172,-0.043439407,-0.09482671,-0.037516784,-0.019534627,0.0021031655,-0.06672877,-0.034128115,-0.022607036,-0.04850585,0.05546641,-0.02911981,-0.05409947,-0.00959914,-0.06790029,0.07203289,-0.089795396,-0.046317816,0.06414462,0.0034620895,0.030127812,0.012023628,-0.062755,0.117685705,0.013528988,-0.07239646,0.016094316,-0.02635013,0.061141293,0.048174623,0.04388575,0.09507145,0.05851053,-0.044653006,0.047798004,0.035931334,0.004190537,-0.061912127,-0.041203342,-0.09506756,0.08123892,0.015998721,0.06822528,0.11065229,0.005970999,0.086138956,-0.0045090737,-0.010451644,0.05662383,0.020976176,-0.059733115,-0.053281948,-0.012996393,-0.042942584,-0.0042557037,-0.037281737,-0.044968147,0.036700703,-0.025708988,-0.0035772999,0.060435295,0.001915325,-0.099983774,0.0041192495,-0.008174031,0.037952356,-4.4957586e-33,0.037812293,0.018736761,0.040899288,-0.10332607,-0.0018522538,0.08069451,0.05723297,-0.054602295,-0.049993712,0.029524157,0.11151095,-0.010668129,-0.005994079,-0.004254599,-0.027173525,-0.010143124,-0.018342976,-0.017745575,-0.059610687,0.038049426,0.05381315,0.011572792,0.026097318,0.06379064,0.06735757,0.048378885,0.044958882,0.0055597955,0.03554368,0.0794203,-0.04744531,0.036176845,-0.093616806,-0.06328292,-0.074349135,0.059631187,0.05080131,-0.012699197,-0.044574752,0.019518033,-0.074171185,0.03233652,0.022968726,0.038464185,0.034093715,0.15672083,-0.023453047,-0.04109902,0.019102175,-0.07926048,-0.038916823,0.055625144,-0.04822633,0.015722785,-0.008061057,-0.008631056,-0.03293457,-0.013238945,-0.0073527414,-0.05978218,-0.018082948,-0.0495878,0.02301717,0.05792161,-0.0014184077,0.025677348,0.012176713,0.00046452176,0.05697211,0.02786366,0.075716116,0.011366153,0.0365392,0.010285296,-0.010313977,-0.0131132025,0.05113621,-0.09998783,0.02849042,-0.08031508,0.03297663,-0.022963455,-0.029261004,-0.06471058,-0.017456438,-0.11989323,-0.023771124,0.07358969,-0.011103769,-0.009082128,-0.0067959623,0.10184485,-0.031465914,0.024237169,0.04333363,-2.6959112e-08,0.005815608,-0.06390062,0.061601352,-0.043880958,-0.01371309,-0.029762233,0.0020119725,0.028970461,0.0283202,-0.0767932,-0.05612699,0.052296523,0.029425321,-0.07168914,0.041432135,0.056215316,0.029168671,0.043153107,0.03033291,-0.011611301,-0.034513164,-0.0385261,-0.03953742,-0.0023848112,-0.010422667,-0.08513484,-0.0010757822,-0.021941386,0.06243174,0.043298315,0.005781181,0.07674181,0.0020462843,-0.012995962,0.09096507,0.03613923,-0.046106514,0.037234068,-0.04070815,-0.056122717,0.013129474,-0.055811886,-0.079764426,-0.008701091,0.007862706,-0.03949023,0.094227545,0.057994153,-0.03090236,-0.026441228,-0.022739487,-0.024101192,-0.0005369411,-0.044864796,-0.071247876,0.0042154104,0.041567598,-0.046813034,-0.035213716,-0.08645984,0.060043737,0.042007033,0.18070467,-0.052384242 +5.3.99.6,"Allene oxides formed by the action of EC 4.2.1.92 hydroperoxide dehydratase, are converted into cyclopentenone derivatives.",384,1.0,0.0018003589,-0.036489915,-0.009096601,0.0019968485,0.11199056,-0.023255587,-0.005953848,0.05229482,0.024430016,0.016170174,0.013737611,-0.013285994,-0.03161984,-0.053474795,-0.023641651,0.12576391,-0.03321085,-0.0022725246,-0.08879937,0.018374447,0.10694289,-0.0033823007,-0.029377908,-0.0038915856,0.061044816,0.051731355,0.06944635,0.03769498,-0.03724727,-0.05755556,-0.00083150464,-0.016690979,0.017570166,-0.09230926,0.04560794,0.017741535,-0.05165136,-0.059868764,-0.07445228,-0.0065017156,0.048662033,-0.03997045,-0.005517953,-0.030092452,-0.06315991,0.010779991,0.023411676,-0.0038760118,0.018396256,-0.0035039047,0.062021025,-0.09830681,-0.031636257,-0.012824128,0.04618186,0.023453655,-0.1062778,0.03690011,-0.020765228,0.0184116,0.07781934,-0.01080585,-0.0074366922,0.04263727,-0.018057736,0.056696206,0.0020849518,-0.0580345,-0.06750599,-0.104605466,0.004175428,-0.04993246,-0.00417347,-0.0373507,-0.0363945,0.031418685,-0.008838148,-0.028352024,-0.007823696,-0.009878459,0.038121086,-0.009763142,0.075711615,0.020062277,0.05773167,0.09849105,0.019864611,-0.078470096,0.036508463,0.028589623,-0.029930536,-0.015041177,-0.016602926,0.007372428,0.059365172,0.045775007,0.081835486,0.09912554,0.05405845,-4.3131615e-05,0.03841507,0.10904805,-0.1596726,-0.06181509,-0.017983843,-0.026795225,0.09526576,0.06619294,-0.03325987,0.052708603,0.027815588,-0.106619306,0.033876922,0.0028406535,-0.0017868289,0.00015343227,0.009947209,-0.0047184047,-0.022596752,0.010985846,0.05216905,0.06240519,0.024804328,0.057952777,-0.023310961,0.05507351,-0.060410786,2.1555424e-33,0.027928002,0.04654894,0.011128035,0.064673536,-0.039217714,0.002198935,-0.10714967,-0.020227686,-0.03602328,-0.042990718,-0.121594846,0.00579664,0.052923203,-0.073290735,-0.0035911482,-0.031783573,-0.018350922,0.04640159,0.058144767,0.015180398,0.030688409,0.08416697,-0.060991988,0.09600156,-0.090668425,0.012140355,0.0059003895,-0.08950284,0.07556465,-0.02322258,-0.103532694,-0.07131205,-0.024241688,-0.058626,-0.039907075,0.04592612,-0.107464865,-0.015852986,-0.038067874,0.0022969241,0.020466348,0.013071705,-0.015734209,-0.054570362,0.018875638,-0.052447196,-0.010323778,0.032205384,0.08038632,-0.038526606,-0.022981586,-0.017620716,0.03009824,-0.042785197,-0.05915675,-0.032311223,-0.055756956,0.056596886,-0.0066945124,0.027926013,0.05510606,0.12715206,-0.011629561,-0.04378397,-0.02888382,0.01869905,-0.016580421,-0.05736719,-0.0819885,-0.035782814,-0.016802907,-0.06359159,0.100814484,0.034296278,0.04283384,0.008209637,0.0070454767,0.0038553905,0.048891984,-0.045360014,0.04668013,-0.022852555,0.027277384,-0.0075418865,0.0146236615,-0.060831882,-0.03217851,0.021463716,0.051482785,0.11114812,0.002972323,-0.12212606,-0.059590913,-0.026375502,-0.051081207,-2.4716297e-33,0.040059555,-0.03520727,0.020252483,-0.057459548,0.021489292,0.054330852,-0.04679378,-0.0658846,0.05962233,-0.030481542,0.119565785,-0.022865664,0.019562628,-0.04808737,-0.007860615,-0.07291816,-0.003323418,0.02625004,-0.010423461,0.04269448,0.037926976,0.030722464,0.13823093,0.025286486,0.072124586,-0.0035208054,0.06319258,0.027662905,0.08683004,0.023024777,-0.06443561,0.0024681964,0.016094133,0.04998249,-0.06990327,0.07600349,-0.056407202,-0.021951785,0.05549988,0.011498434,-0.06564288,-0.06443627,0.015337944,0.044962186,0.069947034,-0.0044527855,-0.075965784,0.01722291,-0.03005831,0.02121032,0.058290135,0.0062876884,-0.109131575,0.04265868,0.016298026,0.047861025,0.036923427,0.018292025,0.005128797,-0.012337314,-0.019241782,-0.01339557,0.07551001,0.0048641195,-0.016817877,0.06861786,-0.037586477,0.11271493,-0.07894077,0.028390076,0.03236202,-0.047698554,0.028236853,0.003553065,0.051045302,-0.08035905,-0.018625297,-0.041643064,-0.05309071,-0.06480151,-0.09656695,0.0032832013,0.05623957,-0.0075025633,0.0037336776,-0.04513509,0.07589882,0.10450204,-0.00018491778,0.032008372,-0.013611445,0.008266738,0.036744643,0.13633233,0.0061238394,-3.0752787e-08,-0.0027671298,-0.029813088,0.09757322,0.006642913,0.028607737,-0.029478554,0.015032773,0.043192573,0.04984417,-0.083903484,0.03363186,0.025155723,0.0035364723,-0.07170752,0.10458967,0.07477404,-0.046773005,-0.0008919866,0.010146972,-0.026966682,-0.03633386,-0.037619695,-0.02743037,0.024153525,0.0009830238,-0.0468541,0.0016854568,-0.01915559,-0.021498114,-0.028282737,0.057968903,0.049900167,0.016576877,-0.0343627,-0.06085299,0.03189277,0.03204852,0.026790021,-0.06082009,0.057354968,-0.110846266,-0.10302984,0.01446993,0.026024643,0.0073444014,-0.02990023,-0.009416815,0.030115701,0.027651547,-0.021028321,-0.026795525,-0.01603828,0.022674615,-0.05488911,-0.024015944,-0.0009491912,0.014395389,-0.027840216,0.03271536,-0.017783238,-0.092857726,0.0098271975,0.13696867,-0.019978134 +5.3.99.7,Highly specific.,384,0.99999994,0.019630184,0.020524966,-0.0230152,-0.020047296,0.024092974,0.0406417,0.01810513,0.021626374,-0.087683104,0.025034381,0.049981266,0.07347534,-0.03327476,-0.005415522,0.014728936,-0.03250771,0.14855814,-0.08265671,-0.08764366,0.0051208395,-0.008628811,-0.0033209734,0.062129613,0.01479178,0.017975545,-0.021437574,0.018815499,0.06956224,-0.014540581,-0.033472992,0.00985978,0.035012644,0.04077409,0.016629338,-0.074339546,0.12060398,-0.06889379,-0.0019449351,0.07577824,0.0128357,0.026173191,-0.012304484,0.034301944,-0.008898489,-0.0014370269,-0.022970771,-0.039906796,-0.016499123,-0.04642852,0.008880071,-0.009253621,-0.06546112,0.04591092,0.016099604,0.032182988,-0.065169394,0.03340078,0.011741369,0.071402214,0.032650072,-0.004116478,0.035665374,-0.08813003,0.021229845,0.1509717,0.0002472862,0.006332941,-0.046821017,-0.03000914,-0.02007239,-0.05246243,-0.040659763,0.027719542,0.009111694,0.07351445,-0.05729846,0.04702543,0.0064067594,-0.015810262,-0.056710877,-0.039893474,0.04909444,-0.0063509145,-0.009688946,0.08913302,0.053284056,-0.024151355,-0.029503722,-0.016472684,0.016280608,0.012094162,-0.07541018,0.11545992,-0.04950364,-0.030986318,0.0024644723,0.042414233,-0.10705784,-0.016860437,0.08021278,0.00860762,0.004037125,-0.03389221,0.050065465,-0.008436746,-0.060979486,-0.047801893,0.054549146,-0.06995602,-0.090007484,-0.11495861,0.0024508026,0.024528276,-0.033106238,-0.042515025,0.05307322,0.023206132,0.023664039,-0.012510923,0.039957467,0.026200978,-0.00594072,0.014255891,0.0049632443,-0.08309666,-0.032914195,-0.073286496,-7.926854e-33,0.03455006,-0.031404287,0.014410953,0.16132574,0.006539816,-0.0012397327,-0.0030263695,-0.012293285,0.013739783,0.067143,0.040282838,0.028888106,-0.07640751,-0.00097101065,0.07610626,-7.87875e-05,-0.08878439,0.058396786,-0.019405626,0.0017028035,0.019590734,0.030960713,-0.037802022,-0.04255902,0.029849818,-0.03250836,0.022277417,0.013941744,0.08840643,0.01628505,-0.061007418,-0.003636679,0.009472894,-0.06365878,0.073859066,0.029568287,-0.010664959,-0.051574916,0.020352978,0.023539122,-0.03575704,0.02146051,0.0051506995,0.09166367,0.04022605,0.033915803,-0.020297216,-0.010514895,-0.10557859,0.017497253,-0.10106621,0.021576107,-0.047632392,-0.03696988,-0.010676392,0.026443284,0.019515676,-0.0055166516,0.0785784,0.013454503,0.013761928,0.12697288,-0.09642051,-0.010007327,-0.07321037,0.058839895,-0.03780467,0.040001158,-0.006584064,-0.011659435,-0.05025824,0.035931997,0.19829985,-0.063189216,0.0035671045,-0.011519132,0.030885028,0.09217766,-0.029138278,0.0038970336,-0.06267852,0.06740324,-0.012650777,-0.004273909,-0.010017325,0.010221874,0.06546703,-0.108032525,0.0076424284,-0.03148979,-0.0564091,0.0041891793,-0.04870975,-0.112549126,-0.05134836,6.412181e-33,-0.04432546,0.009828455,0.042573765,0.059921816,0.09757311,-0.042594142,-0.07790132,-0.0018870387,-0.07278392,0.06629037,0.004876445,-0.0432753,0.06928215,0.00031821025,-0.04232126,-0.046658494,0.028597761,0.062944874,0.0083120745,0.017700948,0.023329148,0.013159454,-0.055838257,0.069176435,-0.072506346,0.02255539,0.005077847,0.009823019,-0.06306149,-0.06425466,-0.011728379,-0.09319706,-0.07560494,0.060201306,-0.09963827,0.05960445,-0.045183856,0.02656103,0.018564759,-0.006812521,0.092576146,-0.074929155,0.012449469,0.099080816,-0.071695164,0.0981975,0.011928692,-0.03380255,0.065547206,0.041073408,-0.13639298,-0.011017294,0.063445695,-0.034465868,-0.026307618,0.025647262,-0.015222279,-0.00776089,-0.008022891,-0.024942756,0.00043230207,-0.018748077,-0.030467527,0.03667369,0.020187015,0.04229571,-0.024786936,-0.07082783,0.04597465,-0.032074668,0.009900857,-0.06623191,0.013014218,-0.031125097,-0.13092577,-0.02688007,0.018633615,-0.003443203,0.0005642689,0.039134625,0.032391503,-0.022759462,-0.046837334,0.055766605,0.082204774,0.05723746,-0.06000702,-0.0021942141,0.07709214,-0.074506976,-0.0339119,-0.09277062,-0.03481143,-0.05412553,-0.009034519,-1.597169e-08,-0.03902775,0.070468016,-0.019455398,-0.009087524,0.023859533,-0.011962539,0.030921767,-0.012907053,0.0037944391,0.0391847,0.011287703,0.062478796,0.06302239,-0.01285154,0.07395657,-0.013552048,-0.017470121,0.05409657,-0.088913724,0.035792217,-0.027000815,0.04636564,0.08569034,-0.047154877,0.051179532,-0.010523361,0.058381774,0.054288268,0.009419741,0.027628561,-0.021505713,0.0030071926,-0.016405545,-0.036033046,0.047253825,0.07232611,-0.02523354,-0.029568175,0.07488461,-0.06413469,-0.02512882,-0.019198509,-0.014097056,0.09558656,0.067996286,0.012986802,0.0065120235,-0.0055387574,0.028456492,0.052861493,-0.047109302,0.06943612,0.010978891,0.05891871,0.051110785,0.030609403,0.0015038289,-0.06334439,0.03703199,-0.043403536,0.13312547,0.0719006,0.025956877,0.031312965 +5.3.99.8,This multifunctional enzyme is induced during chromoplast differentiation in plants [1]. Isomerization of the epoxide ring of violaxanthin gives the cyclopentyl-ketone of capsorubin or capsanthin.,384,1.0,-0.035654653,0.0016927866,-0.09321794,-0.0052586286,0.023448853,0.104207344,-0.057043906,0.038924962,0.05078058,0.003659542,0.10523503,-0.056105427,-0.046341397,-0.041301347,-0.08389676,0.0049170237,-0.14553437,0.07930041,-0.07827265,-0.10581718,0.03061089,0.009837934,0.040273797,-0.014825581,0.04878775,-0.05029876,-0.04486084,0.051660724,0.07986273,-0.08210498,-0.07970576,0.02286947,0.050730746,-0.055112984,-0.029634459,0.11150386,-0.00067668594,-0.066050746,0.06502992,-0.03393582,0.0706112,0.026968153,-0.10465784,-0.008792227,-0.0051886253,-0.0175843,0.051436134,-0.030462962,-0.046917647,-0.023622101,0.04501323,-0.07744786,0.022811621,-0.039840337,-0.03585268,0.014461276,-0.019033732,-0.024965035,0.06230214,0.02341229,-0.016762082,-0.05818868,0.037346806,0.030400993,-0.01796493,-0.062784515,0.031478014,-0.054419614,-0.035366915,-0.03604551,-0.023383953,-0.060918905,-0.0008955683,0.0032595647,-0.03686538,0.04678061,-0.060242124,-0.015754461,-0.039481968,0.05869324,0.0391516,-0.034793753,0.007828905,0.040757652,0.012537567,0.04514141,-0.06519409,-0.017187485,-0.070830114,0.05417362,0.04958993,0.019022724,-0.016543921,0.00890165,-0.04220644,0.05372296,0.07044341,-0.05552482,0.028845415,0.007686836,-0.024593934,-0.020858616,-0.02856217,-0.084516406,-0.0031975724,0.011365405,-0.012889069,-0.02326554,-0.07122408,-0.062357005,-0.041992012,-0.02679722,-0.013624332,0.043043025,-0.017026471,0.07671715,0.03683377,-0.03749374,0.029152812,0.028209263,0.008533938,-0.061168205,-0.015370418,0.039336137,-0.069055244,0.018743685,-0.05806926,3.630274e-33,0.019662194,0.019151544,-0.061447445,-0.036978215,-0.002318872,-0.04192011,-0.044817306,-0.013032602,-0.050632775,-0.06389288,-0.046018153,-0.04711216,0.030549554,-0.047782265,0.00741199,-0.019160762,-0.050211225,0.040182564,-0.00023037197,-0.054056216,0.02534934,0.023961041,-0.07709296,0.03414437,-0.018151993,0.0011960635,-0.012764717,-0.06267193,0.09085243,-0.02439597,0.049083456,0.041036665,-0.032887466,0.060706507,0.062898256,0.068882525,-0.033643715,-0.015273244,-0.05745216,0.06869049,0.0069648586,-0.013954463,-0.043983873,-0.03377991,0.019608935,-0.0222351,-0.116795905,0.06838004,0.06923727,0.028344734,0.0199962,0.05099592,0.05373455,-0.054413926,-0.021959575,0.11874224,0.009974859,-0.011427918,-0.043840196,0.01837111,-0.1104763,-0.008854331,0.02484244,0.03289333,0.030360479,0.063482925,-0.10881253,-0.09707364,-0.036474332,0.023578176,-0.043009445,-0.029767115,-0.016584516,0.034304082,0.022365365,0.02077373,-0.07754005,0.078563,-0.0069709043,-0.01903627,0.030312505,0.009974616,-0.06735027,-0.030901574,0.019312695,-0.037439857,-0.057674754,0.031501148,0.064853616,0.10522035,0.12702645,0.005779234,-0.053774435,0.030033598,0.013848209,-6.107414e-33,0.07763191,-0.024894604,0.043051273,0.006868379,-0.035259847,0.11069689,-0.08049013,-0.024949063,-0.06384114,-0.011865921,0.03919905,0.04645337,-0.05133822,0.049017116,-0.046765752,0.018183544,0.04968476,0.13482763,-0.012410072,-0.010654722,-0.0919428,0.008385826,0.0054476983,0.04901884,0.04836531,0.002211645,-0.06929836,0.019390713,0.015055124,0.01858777,-0.062243827,-0.07927232,-0.048066013,-0.010141736,0.051035736,0.011730012,-0.03218883,-0.034863878,0.040969007,0.09142075,-0.036860287,0.0045836065,0.020048954,0.017834028,0.08744286,0.012313216,-0.035696026,0.0042315866,-0.04310583,-0.019433469,-0.006445195,0.06808065,0.02889963,0.0047997306,0.014560045,0.10095306,0.07386984,0.027251963,0.013818167,-0.016322928,-0.0076094475,-0.06867147,0.0031987452,0.04756686,0.0031139844,0.026106672,0.059738453,0.03072416,-0.031387363,-0.0015524823,0.048764613,-0.005005074,0.059897497,0.033742346,-0.02944654,-0.030908028,-0.026933772,-0.08722499,-0.10366111,-0.06491171,-0.022656986,0.044012476,-0.0066605927,-0.057079814,-0.07733063,-0.07850119,0.028079715,0.131896,0.055576757,-0.038966443,0.020110287,-0.009011958,-0.07327557,0.0069089024,0.14496484,-3.5833988e-08,0.026127368,-0.028763378,0.002753339,-0.068324745,-9.3835624e-05,-0.043083236,0.015414952,-0.050393965,0.010873494,-0.044164117,-0.033006493,0.12075843,0.018039074,0.024805723,0.019129315,0.04395855,0.030229868,0.048116498,0.04021365,0.024699848,-0.10532671,0.006791968,-0.024806805,0.040532444,0.00067620596,-0.024221556,0.036842823,0.13092017,-0.0031738505,0.013525238,0.10776979,0.04999951,0.01386136,-0.04351693,-0.08723001,0.0693255,0.00077450724,-0.06802334,-0.04917628,0.044367466,0.0005874993,-0.043342523,-0.03100625,-0.013289855,-0.013358127,0.022387477,0.060812347,0.03216437,0.019553384,0.0042131315,-0.020267857,-0.024678534,-0.017598607,-0.056375943,-0.05540116,0.04829857,0.06594655,0.02948152,0.0020384786,-0.030694138,-0.08545626,0.037740946,0.17358622,-0.088320315 +5.3.99.9,The opening of the epoxide ring of violaxanthin generates a chiral allene. Neoxanthin is a precursor of the plant hormone abscisic acid and the last product of carotenoid synthesis in green plants [2].,384,0.99999994,0.020527283,-0.06100393,-0.122508354,-0.023286149,0.052934375,0.063139126,-0.026540885,0.03252902,0.062158186,0.0665846,0.09611585,-0.012040647,0.0047168983,-0.10135096,-0.02017401,0.121713184,-0.10687656,-0.0073265717,-0.056301467,0.0064094183,0.043126877,0.00724046,0.026155528,0.008317717,0.01481207,0.03252955,-0.0030201012,0.028325776,0.043753393,-0.062110484,-0.020585824,0.03633039,0.02444259,-0.009538745,-0.013953195,0.04450031,-0.009098665,0.030582806,0.01227729,0.057806395,0.033509877,-0.058476012,-0.010433995,-0.030123921,-0.024246357,0.014484264,-0.030526303,0.006004235,0.001959954,-0.018533967,0.044796456,-0.07469581,0.015113054,-0.00072921236,-0.06915554,0.050707456,0.010711414,-0.015512647,0.053627215,0.070910074,0.09250487,-0.008478839,0.015533757,-0.023324927,-0.057484385,0.015446554,-0.06494586,-0.09499152,-0.018985622,-0.09033343,0.0443144,-0.043489657,-0.1101992,-0.0072567137,-0.020260323,0.030420147,-0.034407005,-0.019671598,-0.013648285,0.02044456,0.03152141,0.04587812,0.02216932,0.08044802,0.020601207,0.08645953,0.002247622,0.021488992,-0.041467257,0.042014226,-0.017982654,-0.027141144,-0.0070080287,0.01334058,0.028749416,0.06436595,0.104409315,-0.14390111,0.041702278,-0.016640028,-0.00388397,0.021882055,-0.06457744,-0.040161792,-0.035948656,-0.017227672,0.01609953,0.04874475,-0.029324375,-0.037167817,-0.013273698,-0.016123904,0.011887798,-0.036399152,-0.033553857,0.084058605,0.0059174197,0.0040598623,-0.0066789826,0.06984213,0.057056,0.048333757,-0.078858964,0.11414278,-0.00570769,-0.011546859,-0.06606844,2.3847252e-33,0.032571048,0.096143186,0.0018914551,-0.026780652,-0.028316453,0.037452884,-0.05972514,-0.10337001,0.014470058,-0.11760785,-0.1479423,-0.063653454,-0.0028492492,-0.025904384,-0.009224131,0.009225781,-0.047823314,0.030469932,0.02887202,-0.06915759,-0.014048312,0.07037923,-0.08389211,0.03457386,-0.04035825,0.0124640735,0.029411852,-0.026866812,0.029091384,-0.055916388,0.028877484,0.017026449,-0.0064370353,0.039242662,0.013752105,0.017355025,-0.06353425,-0.047036234,-0.039694235,0.10680045,0.09566046,0.08758201,-0.003942976,-0.024536807,0.04420312,-0.0798153,0.009656328,0.012755365,0.11020492,0.02019554,0.015396516,0.0819502,0.08334718,0.026897395,-0.064861216,0.039387595,0.016849391,0.0155143365,-0.022944482,-0.006336891,-0.0013791935,0.03218388,0.0048645865,-0.014713923,-0.04488274,0.048723795,-0.08641021,-0.10488864,0.00870249,0.009775097,-0.051143255,-0.04943599,0.016258722,-0.027811911,0.03554491,0.017030422,-0.070004895,0.043807473,0.002264987,-0.03409106,-0.019576663,0.021399202,-0.065026104,-0.025105087,-0.0042038825,-0.0049474738,-0.060318206,-0.010362573,0.046664957,0.04012638,0.047708374,-0.06817925,-0.039359145,0.013622704,-0.0014877842,-1.784288e-33,0.014291544,-0.0742225,0.07474766,0.03128467,0.05465496,0.07545641,-0.09926628,-0.0783436,-0.051905908,0.0384301,0.079670854,0.07571668,0.018728703,-0.009433924,0.031103946,-0.0030684217,0.113453746,0.10237952,0.04554889,-0.015691547,-0.07481516,0.06531302,0.02479422,-0.021654228,0.013664175,0.03414477,0.040073328,-0.0014637369,0.053214613,-0.020735895,0.013730779,-0.050481647,-0.059822224,0.04330029,-0.003332847,0.0131692,-0.070055686,-0.049239907,0.019813446,0.033573095,-0.093049094,-0.032592356,0.04639002,0.053826302,0.029072937,-0.035343643,-0.034117084,0.0014890344,-0.040286757,0.008231008,0.028647736,0.027093964,-0.013136429,-0.004048777,0.02897504,-0.00048429394,0.020262001,0.0614288,-0.0070314594,-0.035395533,-0.029091878,0.0069153276,0.06144866,-0.05713138,-0.021118466,0.0820415,0.0070248954,0.13203251,0.01170473,0.01204717,0.08140493,0.10898918,0.04323026,0.023232335,0.036617246,-0.022282375,-0.0214233,-0.08108704,-0.06710718,-0.07579101,-0.055088263,0.03661136,-0.011410436,-0.030922832,-0.052431107,-0.023001313,0.0131300595,0.1526379,0.0061023,0.022251252,-0.01225268,0.008621316,-0.024928886,0.09713827,0.14757718,-3.110151e-08,8.183665e-05,0.0006827784,0.0023794957,-0.04906617,0.024976848,-0.102177486,0.057244986,-0.02060464,-0.01800306,-0.09930885,-0.0030851837,0.044531085,0.048147004,0.0008879444,0.070549294,0.00693445,0.058091905,0.037360843,-0.0033028303,-0.005023528,-0.078366235,0.016281852,-0.063795306,-0.021094527,-0.039989077,-0.0488705,0.053842723,0.020606844,-0.018107314,0.026617402,0.093183905,0.04244701,-0.011959463,-0.05845911,-0.110001765,0.06120104,-0.0024125043,-0.0016453351,-0.038251568,-0.029924499,-0.020489687,-0.043570444,-0.03308783,-0.0061043245,-0.05293213,0.0076040397,-0.004147692,0.024262764,0.025727682,-0.0152550405,-0.057157286,-0.048234638,0.022180714,-0.05847495,-0.06906454,0.03595174,-0.0025953455,-0.035680566,0.047866557,-0.021985957,-0.11774317,0.014004999,0.1806869,-0.016714426 +5.4.2.1,"The enzymes from mammals and from yeast are phosphorylated by (2R)-2,3-bis-phosphoglycerate, which is also an intermediate (see introduction to section EC 5.4.2). With the rabbit muscle enzyme, dissociation of bisphosphate from the enzyme is much slower than the overall isomerization. These enzymes also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase; they were formerly listed as EC 2.7.5.3. Enzymes from wheat, rice, insects and some fungi, however, have maximum activity in the absence of 2,3-bisphosphoglycerate, and were formerly listed under the present number as phosphoglycerate phosphomutase.",384,1.0,0.068239346,-0.072618224,0.011180082,-0.01302072,0.040218536,0.0044226144,-0.008717396,0.023477744,0.057829995,0.06003193,0.058957767,0.0019301493,-0.04418069,0.072245434,-0.033393066,-0.009770355,-0.02237293,-0.018329063,-0.025178537,-0.0011298626,0.13806364,0.005804044,-0.0047562923,0.0406797,0.095668554,-0.09598979,0.008137775,-0.08378436,-0.068302654,-0.067147695,-0.07534794,-0.05675615,0.080030106,-0.049728483,0.005054472,0.07850171,-0.017399816,-0.07141314,0.07023203,0.0030050545,0.007291384,-0.02003315,-0.023595516,-0.08053824,-0.026884839,0.04813693,0.050947014,-0.018707018,0.028354658,0.0035328867,-0.07278244,-0.056212403,-0.04657117,0.02457716,-0.018852564,-0.00062787853,-0.067297146,0.081130035,-0.03120418,0.021361895,-0.02229265,0.008540447,0.05006662,0.022769751,0.037505705,-0.034456942,0.02902554,-0.06473965,0.019828124,-0.01542806,-0.06702642,-0.05057012,0.041476034,-0.027247502,0.019088795,0.031318873,0.0022684021,0.02275495,-0.0029765007,-0.090608165,-0.026204359,-0.05132315,0.0037420064,-0.076868266,0.0042650127,0.046272896,-0.009431793,0.01910355,0.007816769,-0.011584229,0.05108094,-0.008036561,0.07003751,-0.015869182,0.037674576,0.03427001,-0.01596897,0.08077448,0.042169712,-0.06230067,0.014167034,0.11516414,-0.0025138177,-0.070250474,0.031631213,0.047855936,-0.02627289,0.007650387,0.0259839,-0.007537873,0.050180156,0.0049487706,0.05456547,0.06087337,0.021109687,0.056937214,-0.0025217382,-0.10464019,0.011964431,0.03136981,0.0089457845,-0.059008423,0.006116762,0.058409482,-0.063950434,0.121772096,-0.08642299,3.585872e-33,0.04818955,0.017411126,-0.0070088194,-0.0062600886,-0.038794037,-0.017063254,-0.055397168,-0.019242978,-0.04311596,-0.052722633,-0.030065434,-0.013837219,0.075099826,0.02496502,0.016049014,-0.01327949,0.03206223,0.00771508,0.1267578,-0.009677209,-0.015411165,0.023430867,-0.072605334,-0.026969943,0.11160781,0.08873999,-0.06712478,0.00589172,-0.01866582,-0.030840151,0.06463528,-0.077865936,-0.08100626,0.07854108,0.011928763,-0.07384788,-0.002181142,-0.011760978,-0.03900997,0.004983535,0.025105935,-0.028324539,0.018064642,-0.021609638,0.09233932,-0.022601895,-0.07490454,0.07984252,0.08806774,0.062498156,0.02171835,0.02027332,0.15801105,0.005446118,-0.023851285,-0.021055369,0.00644536,-0.072765425,0.003403302,0.10194409,-0.034158316,0.10826917,-0.03682278,0.0180615,-0.025817167,0.017125841,-0.13226101,-0.02628777,-0.0145490635,0.09420478,-0.05369833,-0.052304126,0.035012227,-0.028735854,0.021711085,-0.04306814,-0.026417213,-0.029546782,-0.062182344,0.03094429,0.029686209,0.022172306,0.016806796,0.015491016,-0.0982532,0.04027981,0.045026015,-0.0763642,0.027738027,0.08776632,-0.01316618,-0.024369886,-0.086417936,0.07481399,-0.004195804,-3.0910197e-33,0.15579185,-0.03024505,0.047637966,-0.033930726,-0.08099209,0.07098141,0.047739178,-0.01680584,0.017191732,-0.06340511,0.024162812,-0.050017707,0.047748305,-0.058912266,0.0384032,0.039418705,0.026370164,0.049008027,0.032229446,0.008031334,0.022905175,0.10690292,-2.4529298e-05,0.04489095,0.12862615,0.0010938813,0.008139369,0.031738997,0.0006011454,-0.023981044,-0.059934016,0.0032936914,0.014166043,-0.073674686,-0.06618962,-0.043301273,-0.10450236,0.008101489,0.03823745,0.00084253744,0.00025747638,0.037444618,0.027858622,0.044643585,0.0063802223,0.052691422,-0.024523983,0.030209674,-0.047456935,0.0389138,0.021718327,-0.01639663,-0.000414711,0.019016633,0.08457594,0.02739428,-0.036951233,0.06022472,-0.05033416,-0.0596344,-0.015941042,-0.04769196,0.060906373,-0.009302726,0.0839679,0.044102877,-0.09350701,-0.011796646,-0.02983077,0.023115607,0.03628516,-0.02048597,-0.0010782714,0.013200613,-0.005431957,0.03176164,-0.0849326,-0.016674954,0.0071435426,-0.037622724,-0.042913646,0.06012863,0.049145415,-0.05423998,0.013155644,-0.017510263,-0.046828825,0.078976214,0.06078218,0.0134831825,-0.016306642,-0.116763905,-0.0041297185,0.0032459712,0.08007088,-4.3297245e-08,0.040504653,-0.007878013,-0.019424088,-0.054267805,-0.00053432374,0.007355275,0.06784884,-0.0019873756,-0.005040704,0.02220241,-0.045381863,0.013355712,0.039901454,0.018345026,0.04410405,0.0037911884,-0.04308223,0.004332308,-0.012092665,0.03202594,-0.06471956,-0.052911434,-0.14688309,0.10355673,0.02480361,-0.021772455,-0.007939626,0.030972539,-0.057938322,-0.018523678,-0.023883235,-0.021936694,0.025526341,-0.048074152,-0.018690443,-0.01669411,-0.049904,-0.0140800765,-0.1159035,0.044811096,-0.014255048,-0.093931705,0.0010906872,0.014135705,-0.012552145,-0.049712267,-0.024313292,-0.015492362,0.06785646,-0.04713747,0.052193828,-0.024497442,-0.043040816,-0.090159915,-0.09028608,-0.03670264,0.043170046,-0.062980086,-0.018254371,0.020326154,0.10235145,-0.011117149,0.14496394,-0.0733989 +5.4.2.11,"The enzymes from vertebrates, platyhelminths, mollusks, annelids, crustaceans, insects, algae, some fungi and some bacteria (particularly Gram-negative) require 2,3-bisphospho-D-glycerate as a cofactor. The enzyme is activated by 2,3-bisphospho-D-glycerate by transferring a phosphate to histidine (His10 in man and Escherichia coli, His8 in Saccharomyces cerevisiae). This phosphate can be transferred to the free OH of 2-phospho-D-glycerate, followed by transfer of the phosphate already on the phosphoglycerate back to the histidine. cf. EC 5.4.2.12 phosphoglycerate mutase. The enzyme has no requirement for metal ions. This enzyme also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase.",384,1.0,0.013638382,-0.047799412,-0.037475154,-0.07865632,0.01404395,-0.010465435,0.0032588467,0.011812051,-0.035131183,0.05882985,0.04928589,-0.033825736,-0.04546435,0.04892087,-0.07296689,-0.035553876,0.013787758,0.02761458,-0.065615185,-0.019886311,0.15413249,0.018958354,-0.019524822,-0.05102811,0.01653803,-0.0037095123,0.015816048,-0.08046549,-0.027632184,-0.04800263,-0.06819108,-0.07856905,0.09049997,-0.08078722,0.02276964,0.06950096,-0.02127038,-0.024920179,-0.021141376,0.06264398,0.029636504,0.007257208,-0.025579656,-0.028381662,-0.045268834,-0.036474567,0.033425607,-0.019404635,0.0160612,-0.0012936101,-0.060224447,-0.05662767,-0.037077054,-0.007103886,-0.026319763,0.038448606,-0.052599136,0.04092587,-0.013187501,-0.039451372,0.0056986907,-0.03632511,0.12395676,0.02868051,0.071920834,-0.036730036,0.042751916,-0.059326965,-0.057037525,-0.010959337,-0.060766015,-0.053304464,0.040703457,-0.024724385,0.02545259,0.04563632,0.014494915,-0.014381058,0.059511717,-0.020585466,-0.006697702,-0.035105646,0.04280715,-0.011447777,0.007759212,0.058020163,-0.018877523,0.013111632,-0.0046377713,0.009686531,0.061367642,-0.058795936,0.04793114,-0.08319779,-0.028477317,0.047891986,-0.011324186,0.079121456,0.025057482,-0.05180608,0.0075585754,0.11111466,-0.041736633,-0.045574654,-0.032098457,0.051528387,-0.013019818,0.08068127,0.0036018966,0.009034911,-0.0071640546,0.041001074,0.056831528,0.008604819,0.0092445435,0.101919405,-0.010190242,-0.079581976,0.014934385,-0.030728437,0.013839553,-0.07199313,0.022731217,0.063601434,-0.019844478,0.085755944,-0.10319973,4.3324644e-33,0.052096024,0.075473666,0.0082127275,-0.010140814,-0.05298888,-0.054555323,-0.0863144,0.01908228,-0.04861608,-0.069879554,-0.03956448,-0.0040503903,0.092675544,0.00070369476,-0.049952373,-0.020217488,0.06285468,-0.018482585,0.12617216,-0.016662274,0.078612745,0.04754197,-0.01652667,0.0051724087,0.098470405,0.09599358,-0.068717636,-0.027234582,0.00036341592,-0.010753029,0.009853388,-0.075680055,-0.062468152,0.05078239,0.02187551,-0.055231735,-0.05608843,-0.02249508,-0.010308483,-0.0067516644,0.0041709696,-0.012704468,-0.024808045,0.01477351,0.074831,-0.08000259,-0.061562814,0.07461147,0.10246268,0.08081033,0.052653424,-0.006904956,0.094162785,-0.0394355,-0.08781769,0.051581707,-0.019296538,-0.06152378,0.069585554,0.08372669,-0.033292938,0.056502573,-0.01972342,0.057591308,0.04326188,0.032213207,-0.094103895,-0.059191745,0.004092419,0.09117847,-0.074546404,-0.009179947,-0.010859265,0.04973076,-0.02075381,-0.040179517,0.0010678743,-0.04303794,-0.042190515,0.010823226,0.05275624,-0.018914113,-0.015837641,-0.037053697,-0.04023294,-0.0041284934,-0.00016754032,-0.08194832,-0.0012461575,0.040552534,0.029058626,-0.07974403,-0.051781427,0.00814079,0.005915114,-5.6003174e-33,0.16096884,-0.06850963,0.038507402,-0.029794158,-0.08566594,0.096255235,0.048023317,-0.009823462,0.055877555,-0.06605301,-0.011819077,0.0060609123,0.07272926,-0.07287743,-0.029975303,0.032496024,0.026971307,0.05564567,0.0057301475,-0.042575233,0.033499327,0.10298283,0.04655363,0.043169815,0.07881245,-0.008725842,-0.0184397,0.05361084,0.01659565,0.0016477406,-0.051498294,0.028225796,-0.0028071152,-0.07428279,-0.06846634,-0.010290088,-0.107384786,0.03449109,0.006993469,0.035502445,0.005585277,0.047098413,0.040158406,0.08102669,-0.013592446,0.13372499,-0.077567026,0.05158135,0.004547039,-0.019833524,0.008896094,-0.0024687503,-0.022588568,0.028603049,0.11377524,0.07086325,0.03471173,0.02730529,-0.06921385,0.0062428215,-0.028601663,-0.07122902,0.050409384,-0.025779406,0.048652206,0.05654888,-0.046360467,-0.020393724,-0.028902879,0.0148186,0.0044524805,-0.006800502,0.0020841176,-0.011808602,-0.029124992,-0.01859851,-0.086564146,0.0012357084,0.03973929,-0.02303314,-0.0006494297,0.034161706,0.04814111,-0.029071808,0.056443922,-0.10939523,0.021928174,0.12575994,0.018203737,-0.01161361,-0.06475037,-0.06277175,0.010524968,0.0011671338,0.06760825,-5.3734055e-08,0.04208337,-0.0193656,0.0623844,-0.07481287,0.0035486436,0.058872223,0.0025229629,-0.043389637,0.033804048,-0.031809412,-0.04391651,0.06677705,0.019901829,-0.026711142,0.03125755,0.061750796,-0.04476744,-0.026876269,-0.027085144,-0.037225947,-0.080791794,-0.054271538,-0.10786359,0.11579457,0.033355426,-0.020165203,0.056568902,0.03134807,-0.035613164,-0.010562451,-0.059725437,-0.016512206,0.022170758,-0.027792746,-0.049504012,-0.0017195487,-0.04889336,-0.017825292,-8.5459775e-05,-0.011909229,-0.014266677,-0.0111860735,-0.03310008,0.025246548,-0.026330955,0.013272823,-0.044475134,0.017405752,-0.010600313,-0.02388113,0.046987794,-0.047295466,-0.019951379,-0.08475657,-0.10692054,-0.008589095,0.03535656,-0.09269311,0.0029070259,0.014894988,0.07914711,0.01176848,0.14637454,-0.096409366 +5.4.2.2,"Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. The enzyme also catalyses (more slowly) the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. cf. EC 5.4.2.5, phosphoglucomutase (glucose-cofactor).",384,1.0,0.016887965,-0.0931989,-0.029728051,-0.06624305,0.023594113,0.0040416275,0.04107403,0.062217288,0.021253077,0.08579647,-0.018377908,0.09828773,-0.06313613,0.077154204,-0.042660434,-0.041661546,-0.013201288,-0.016089184,-0.0770955,-0.024491707,0.13856092,-0.023132907,-0.015615816,-0.00948647,0.103433564,-0.0061175255,0.047230635,-0.047348987,0.03931105,-0.054101206,-0.051753793,-0.06999449,0.10728429,-0.027216204,0.012651771,0.14463133,-0.03912895,-0.08626432,-0.027008368,-0.004558582,0.016832534,-0.02135994,0.025968093,-0.028754324,-0.057722185,-0.018240456,-0.06645403,0.012703958,0.03197064,-0.021749124,-0.040888596,-0.05263033,-0.049392354,-0.034453448,0.0041619833,-0.00770142,-0.03312607,0.037062544,-0.00955903,-0.016169501,-0.031186555,-0.0007708905,0.029508526,0.040707793,0.08979628,-0.0752283,0.045638774,-0.07780702,-0.02696598,0.020462826,-0.07369057,-0.0048749405,-0.01612982,-0.026814891,0.0077162017,-0.010198988,-0.062364206,-0.023028672,0.009962378,-0.06726924,0.057550058,-0.042446543,0.04729032,0.026556982,-0.015433997,0.013303067,-0.026460502,0.03098408,0.08009579,0.007413269,0.0031300713,0.047318183,0.0022076312,-0.04241933,0.0065418594,0.017744299,-0.03472321,0.0414922,0.035247307,-0.0401227,0.014982145,0.10806886,-0.048505574,-0.04667075,0.0029788027,0.023620525,-0.044509634,0.041099668,0.016544146,0.052548114,-0.0026945968,0.014368486,0.03856638,0.006344068,-0.03593527,0.08458497,0.03114717,-0.071671024,-0.011887506,-0.006584935,0.030865023,-0.08760799,0.048702803,0.058088724,-0.075900376,0.12115784,-0.031931538,5.056487e-34,0.037592247,0.021093292,0.018793305,-0.011916901,-0.087062486,0.027190296,-0.07429937,-0.02326905,-0.04370255,-0.003335336,-0.07746764,0.009241775,0.055940956,0.018816609,0.010596248,-0.014738029,0.0428494,0.058167864,0.064078085,-0.0071396185,0.044982336,0.048303287,-0.054821894,0.012678914,0.048245996,0.071842976,-0.06533459,0.06025605,-0.024055207,-0.0259842,0.060840786,-0.046870247,-0.09217012,0.042409647,0.0120935,-0.0545059,-0.05846009,0.022075554,0.010821631,0.006632074,0.033650372,-0.03538535,0.025377227,-0.05009532,0.0771344,-0.04349621,-0.0047945944,0.052821103,0.06350254,0.07573689,-0.0013814332,-0.0008693913,0.05927589,-0.03885497,-0.037541013,-0.002216869,0.005963484,-0.07818199,0.0856121,0.10948139,0.009164114,0.077519976,-0.012987838,0.07186791,-0.00248863,0.016901491,-0.07100659,-0.035323627,-0.0033085216,0.08868373,-0.022784717,-0.045286972,0.07445548,-0.06023353,0.029932512,-0.057212427,0.006154402,0.021678505,-0.049180336,-0.010526158,0.018252918,0.024451911,-0.00050746644,-0.057169437,-0.11008188,0.028538423,-0.02141346,-0.058667604,-0.08033467,0.058659747,-0.004251778,-0.0356501,-0.09375557,0.039988507,0.030647015,-2.7462816e-33,0.16008502,-0.071736135,0.07991039,-0.106902786,-0.06484651,0.056679677,0.10919763,-0.03291116,0.071690634,-0.005451559,0.030966606,0.034974843,0.0127655035,-0.046266742,-0.027946753,0.062882304,-0.025390279,0.11752711,0.027970003,-0.018792367,-0.024320763,0.13354585,0.020924473,0.09597754,0.095891304,-0.031279087,0.010023736,0.0035785385,0.01282495,0.0064790775,-0.009864369,-0.024669942,-0.0388782,-0.017269759,-0.086958624,-0.0031249865,-0.09052987,-0.002607364,0.0036744822,0.007822291,-0.02714323,0.07416305,0.047824305,-0.0063316636,0.089320265,-0.013894103,-0.046207663,0.0014081298,-0.049422614,-0.007454532,0.01004494,0.010121248,-0.03337392,0.02890867,0.07676559,0.07263152,-0.038378745,0.060035966,-0.0912949,-0.049662966,0.021305922,-0.03362084,0.020806687,-0.015784375,0.082520775,0.037077487,-0.016202696,0.02025224,0.024694482,0.030964943,-0.002171758,-0.00068634766,0.0025217505,-0.024798302,-0.0137252845,-0.014940524,-0.0519085,-0.0017496406,0.006748064,-0.053517655,-0.08665514,0.0844643,-0.031292915,-0.08095038,-0.030910283,-0.07800063,-0.0067339293,0.05269377,0.07167829,0.032408558,-0.04903932,-0.07047141,0.012794982,-0.038553167,0.053838827,-4.3679748e-08,0.047317486,-0.0026806328,-0.010112549,-0.056907326,0.050305087,0.021078642,0.027415453,-0.01670659,0.06537922,0.013892471,-0.03525608,0.07479393,0.012719499,-0.0013087151,0.025900275,-0.026447643,-0.10698806,0.005233127,-0.028769681,0.0005844238,-0.023228789,-0.042004414,-0.10573614,0.040713962,0.008963146,-0.0597947,0.05892823,0.017207546,-0.05391701,0.032549553,-0.03238602,0.008821765,-0.009981346,-0.048675325,-0.023076925,0.03586851,-0.002214152,0.042365547,-0.08449349,0.059527304,-0.032574426,-0.14039817,0.014929586,0.023450978,-0.0455938,0.080424815,-0.032266833,-0.020016942,0.04001377,0.013154019,0.021504387,0.011380528,-0.11624191,-0.104896694,-0.03196625,-0.030771337,-0.03811986,-0.048121933,0.0028068353,-0.05084901,0.07809224,0.008361407,0.14480717,-0.04815133 +5.4.2.3,"The enzyme is activated by N-acetyl-alpha-D-glucosamine 1,6-bisphosphate.",384,1.0,-0.023519862,-0.07797919,-0.10295746,-0.032242976,-0.0037565466,0.01607248,0.041384842,0.010046535,0.053607687,0.061091788,0.024254695,0.046937514,-0.030284883,0.037610903,-0.061611235,0.04805746,0.0013786464,-0.07754638,-0.0060886363,-0.043089103,0.09775104,0.021736117,-0.021949645,-0.053094067,0.05479117,-0.013767628,0.09089742,-0.015174801,0.02312432,-0.01737088,-0.057410676,-0.0040197815,0.11754513,0.012936674,0.014007255,0.09027486,-0.06605697,-0.02584415,0.03285287,0.04942883,0.017955327,-0.017367529,-0.025828632,-0.06923429,-0.051068813,-0.016086822,-0.030938108,0.09072514,0.06223382,0.0320878,0.08083843,-0.06217636,0.009694332,0.011764588,0.020604597,0.044985127,-0.090510175,0.019080317,-0.040200293,0.05285921,0.04354128,0.046740178,-0.026001945,0.008837998,0.06850397,-0.057591956,0.03703546,-0.057119112,-0.002235521,-0.04514764,-0.01710038,-0.023250936,0.05039718,-0.04552616,-0.010484008,-0.08246193,-0.0251451,-0.020411367,0.10613547,-0.03351257,0.044322416,-0.0100197485,0.047911834,0.10043543,0.052028697,0.08468841,0.021319544,0.06008271,0.0452445,0.0052217664,-0.011005994,-0.07728577,-0.057978112,-0.07564263,-0.0721537,0.00973244,-0.044006176,0.024617098,-0.034380194,0.008613291,0.016526435,0.078902505,-0.0080651855,-0.065269016,-0.06646465,0.025160097,-0.012053515,0.06294608,0.016033577,-0.007190481,-0.067260906,0.034571853,0.06285699,0.0427243,-0.07677489,0.13116407,-0.0026222572,-0.030278195,-0.02957632,-0.017289644,0.05304757,0.0074139903,-0.01934549,0.09966161,-0.07202989,0.074197814,-0.005795169,-1.2396796e-33,0.05395604,0.06147855,0.018998163,-0.04536355,-0.021221874,0.011367396,-0.04379646,-0.02853076,-0.031911366,-0.0027495036,-0.014886152,-0.07365806,0.0639037,0.032382354,0.011699849,0.0031715427,-0.022576984,-0.004128333,0.103027016,-0.014982357,0.06672109,0.09252501,-0.06970611,0.01615772,-0.06280825,0.06683449,-0.049574353,0.07734319,0.06456432,-0.02426828,0.014525879,-0.049592387,-0.084553644,-0.0074404324,-0.034146074,-0.030099161,-0.027946308,-0.04594149,-0.002091012,-0.018036464,0.069119,-0.0070454446,-0.011076518,0.014917439,-0.010444712,-0.06405941,-0.07656995,0.04537328,0.080976084,0.09917296,0.075927526,-0.03686893,0.09978057,-0.065136366,-0.07391329,0.047961693,-0.051717065,-0.11641475,0.027489237,0.04277224,-0.001973344,-0.052448526,-0.03793268,0.051231556,0.0050439374,0.014726971,-0.027731495,-0.09136144,0.042346947,0.082254894,-0.06194485,-0.028908188,0.022368083,0.039993964,-0.058311936,-0.021919152,-0.0067356657,0.04478694,-0.015572507,0.005214408,0.026422378,-0.042722117,-0.013626115,0.020750036,-0.08078045,-0.00021846752,-0.009650216,-0.08841958,-0.022746753,-0.012198491,0.039220013,-0.08854689,-0.11846972,0.07280733,0.025558898,-1.0666567e-33,0.11972882,-0.08898403,0.03136394,-0.041881602,-0.0745857,0.06586241,0.0791735,-0.054985095,-0.011412279,0.0016436692,0.026607117,0.0030272147,-0.025529621,0.013091384,0.018151961,0.026666574,-0.02290287,0.059504904,-0.007299712,0.03342381,-0.009871667,0.06749848,0.029261025,0.048494656,0.074521914,-0.026771022,0.061565027,0.03307142,-0.0028179754,0.066754684,-0.02557354,-0.046909146,0.0012740807,-0.036231924,-0.014819955,0.08386692,0.0067330785,-0.016353715,-0.0767389,-0.02685983,0.009355568,0.06613346,-0.013998618,0.09925223,0.029399019,0.061975975,-0.037812065,0.03537186,-0.09929481,-0.02973595,0.008214956,-0.00739301,0.053529814,0.005441218,0.07432296,0.050306503,0.003349451,-0.017824458,-0.06491588,0.010412463,-0.045056157,0.0048671993,-0.03560934,-0.016359875,0.04347328,0.018145662,-0.024017049,0.06709458,0.001053534,-0.015731448,0.011161713,0.047549374,0.06555856,0.011872047,-0.0404025,-0.08786583,-0.06671565,-0.041739434,0.013541081,-0.058963373,-0.017232778,-0.008332813,-0.039762545,-0.0077131875,-0.048429277,-0.03785438,0.0855053,0.103595525,0.045696586,0.07062454,-0.06842114,-0.02548469,-0.082941055,-0.009395788,0.034261554,-2.9645399e-08,0.03225432,-0.05207311,0.0275132,-0.121339954,-0.002063968,0.030367747,0.052535255,-0.006192241,0.0039630122,-0.06726626,-0.026855282,0.10311376,0.018391429,0.012034377,-0.0010241581,0.009189403,-0.020330112,0.04199577,-0.027492007,-0.041524887,-0.08326727,-0.042538255,-0.044142216,0.029237328,0.0473328,-0.0670588,0.023260942,0.104353055,-0.021537947,0.017925331,-0.012944626,0.0032037555,-0.011210595,-0.10799824,-0.029539358,0.11481629,-0.012511894,-0.010136509,0.0038341023,0.005215463,-0.015433318,0.02463831,-0.010009922,-0.011538404,-0.0506849,-0.0024903768,-0.020730868,-0.012463255,0.020891443,0.036886293,0.013309499,-0.039792363,-0.0423344,-0.09812244,-0.11141441,-0.06514851,-0.055910945,-0.10619536,0.04563372,-0.019550735,0.015131196,0.03825829,0.14774156,-0.07229957 +5.4.2.4,"In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. This enzyme also catalyses, slowly, the reaction of EC 5.4.2.11 [phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)] and EC 5.4.2.12 [phosphoglycerate mutase (2,3-diphosphoglycerate-independent)].",384,1.0,0.028792279,-0.062742785,-0.0019097774,-0.034107175,0.08800318,-0.027711388,-0.0075589577,-0.026015475,0.052930877,0.048037518,0.012712616,0.00036483648,-0.019063001,0.018494274,-0.05239387,0.0300203,-0.036437053,-0.0061980607,-0.03737011,0.029155739,0.16703203,-0.047177695,0.007955929,0.03916453,0.053472072,-0.050903317,0.06842308,-0.05547,-0.0591329,-0.090657,-0.049471006,-0.056290872,0.060618393,-0.05337614,0.012801227,0.07972794,-0.068797424,-0.06157486,-0.015647244,0.039794978,0.027954679,-0.011464082,-0.033901904,-0.07333251,-0.050741524,-0.030862613,0.0016834401,0.018281735,0.02486587,-0.013640589,-0.099087276,-0.077571765,-0.07524813,-0.017676271,-0.008711457,0.029987158,-0.09824292,0.106560126,-0.030810585,-0.006951122,-0.015393252,0.0065281824,0.06598706,0.0010027305,0.08344937,-0.024700627,0.039185755,-0.056828663,-0.028963557,0.017733388,-0.06560871,-0.01889805,0.056927286,-0.064400025,0.047592152,0.02991592,0.0355607,0.032629397,0.016104927,-0.05890662,0.03143923,-0.04689117,-0.050619744,-0.017605923,-0.016977105,0.04865707,-0.009972375,0.004797179,0.028144808,-0.03134248,0.04259602,-0.028747989,0.05224066,-0.043764453,-0.0009073458,0.062566064,-0.05208144,0.0569488,0.013126409,-0.0433448,0.008361268,0.14406157,-0.004799179,-0.091535315,-0.0077034873,0.07626176,-0.031142067,0.05904957,-0.022034975,0.014736075,0.037029948,-0.008240554,0.062661394,0.041289065,-0.028758023,0.13182288,-0.039530396,-0.09151529,-0.023949666,0.03407842,0.049984165,-0.057499234,0.019945337,0.050194263,-0.08860579,0.08903513,-0.07751736,7.5968585e-33,0.039372798,0.047229618,-0.005341123,0.0027010299,-0.029818758,0.0018790318,-0.062103704,0.0122408345,-0.1454452,-0.011666119,-0.02769678,-0.032018557,0.12310846,-0.0060327537,-0.013392004,-0.058250878,0.0142455,0.01400305,0.0779081,0.035705328,0.028572682,0.03376648,-0.08715034,-0.0037010063,0.054633822,0.05847232,-0.05263679,0.0108942045,0.004139816,-0.009891706,0.06898807,-0.057782825,-0.0866652,0.0007596354,-0.0013887751,-0.10823939,-0.047606178,-0.030720295,0.0020710763,0.019517118,0.00666844,-0.02208675,0.008582497,0.014391298,0.07073189,-0.059886605,-0.07235693,0.09704415,0.1235182,0.08904642,0.034436315,-0.026570039,0.14236525,-0.005184087,-0.059291754,-0.007859312,-0.011850098,-0.04535422,0.0744206,0.044317257,0.003723001,0.04736324,-0.031640485,0.020475801,-0.01707979,0.06446778,-0.06949378,-0.025229758,0.004893573,0.09527629,-0.033390235,-0.016979657,0.030687818,0.037985526,0.026023848,-0.06231735,0.003085106,-0.0021662624,-0.053694464,0.043617196,-0.003219902,0.008685528,-0.016112527,0.028446639,-0.059921686,0.0205003,0.013142298,-0.06751518,0.0030346417,0.13844313,-0.011252561,-0.06902749,-0.09028052,0.032305278,-0.0045087542,-6.864262e-33,0.16065559,-0.06544325,0.009308501,-0.056435253,-0.07575803,0.035077758,0.04990085,0.0013246442,0.032135315,-0.04325016,0.03441457,-0.0461637,0.047954854,-0.05244294,0.035765786,0.05584566,0.039031077,0.03867047,0.018249584,0.024612298,0.083500735,0.10263815,0.0041258265,0.05927988,0.0567621,0.011249916,0.0072350665,0.050499417,0.0010681585,0.038570262,-0.08110869,0.000981322,-0.040267948,-0.02863031,-0.07563148,0.005582136,-0.08541345,-0.026632208,0.024830936,0.014475065,-0.037902124,0.04792517,0.067490965,0.022760918,0.038108695,0.09406544,-0.016723331,0.044947233,-0.010884458,-0.013133474,-0.005169093,0.017850837,-0.010136153,0.08464044,0.060216393,0.035228495,-0.044886377,0.03073206,-0.03707011,-0.031009816,-0.009141725,-0.078520924,0.05946158,-0.0112475315,0.09344055,0.06841178,-0.066279754,-0.01948969,-0.010881923,0.027090713,-0.0039714677,-0.039463997,-0.009286245,0.022704033,0.0026799135,0.03626615,-0.10628338,0.034569807,0.002887832,-0.056450963,-0.016012533,0.024880987,0.009802362,-0.08439957,0.0015669317,-0.047464322,-0.01501956,0.065483406,0.03928264,0.0143682,-0.03243287,-0.06455552,-0.0026762018,-0.03562366,0.08457063,-4.9632174e-08,0.052308366,-0.06329247,0.0035862152,-0.051037192,0.03133354,0.055720225,0.046525743,-0.016037941,-0.004509285,-0.034090854,-0.03445382,-0.0050431695,0.042071685,-0.026578154,0.06579725,0.023711324,-0.07877958,0.004151598,-0.013159053,-0.01674693,-0.031913437,-0.034664884,-0.11401675,0.0682536,0.022829948,0.025280472,0.038026284,-0.0229874,-0.089358315,-0.023215273,-0.025333375,0.0133974925,0.015745979,-0.035647053,-0.034364607,0.023213008,-0.06272224,0.022203991,-0.07454921,0.057196233,-0.030090831,-0.06541841,-0.036922116,0.0037405114,0.0008017355,-0.0033928617,-0.0044925087,-0.029758506,0.04355807,-0.051705398,0.041007034,-0.049955603,-0.032237332,-0.06711936,-0.08647674,-0.045711577,0.025692662,-0.07420121,0.003915962,-0.008528778,0.06711877,0.04005941,0.14163794,-0.06961338 +5.4.2.5,"The enzyme is activated by D-glucose, which probably acts as an acceptor for a phosphate residue from the substrate, thus being itself converted into the product. cf. EC 5.4.2.2, phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).",384,1.0,-0.028427333,-0.0264975,-0.039462063,-0.006146839,0.060720764,0.00234349,0.10130547,0.041557968,0.047812577,0.073772356,0.009839551,0.03447274,-0.08241381,0.0348747,-0.040208206,0.01755905,-0.048870295,-0.002483937,-0.058610793,-0.04200702,0.18621743,0.04018613,-0.01578579,-0.011749254,0.08717459,-0.035831306,0.063319154,-0.08810721,0.018725457,-0.028706798,-0.06501911,-0.052836824,0.059727903,0.00025061253,-0.0077554737,0.110044986,-0.02329692,-0.07926378,-0.034389585,0.00458684,0.09833898,-0.052043978,-0.039914493,-0.027491001,-0.081149265,-0.00032809324,-0.04816824,0.06765575,0.02171924,0.017221263,-0.013567584,-0.058982875,-0.05209596,-0.018310385,-0.035276495,0.059952702,-0.009206435,0.021703314,-0.023767505,-0.043157663,-0.039087806,-0.0039622774,-0.003279117,0.047614243,0.06219274,-0.10830514,0.037618514,-0.07608265,-0.015115602,-0.086326666,-0.06231878,-0.056801755,0.01589673,-0.03669589,0.05793295,-0.033196583,-0.038864464,0.0039152848,0.08485285,0.009511227,0.105016895,-0.019942893,0.016143043,0.06286775,0.022062011,0.007128425,-0.004381622,0.032889146,0.0525641,0.0049741156,-0.017526075,-0.065522596,-0.035134267,-0.012263956,-0.030488418,0.00026188148,-0.023103697,0.007855262,0.059850365,-0.013942076,-0.0024796552,0.09704155,-0.021968007,-0.0943939,-0.076915175,-0.004604497,-0.031560715,0.030262187,0.009145949,0.018281024,0.00069794315,-0.0039582597,0.066128746,0.029043797,-0.03971869,0.113244,-0.008421282,-0.10282916,-0.037620604,-0.020712351,-0.008205948,-0.025121607,0.031729154,0.0507774,-0.07801763,0.12988053,-0.037324782,-3.5779157e-33,0.0039335587,0.000979371,-0.0022856717,-0.025078112,-0.06553735,0.02315372,-0.055914063,-0.020241732,-0.07550662,-0.019233322,-0.07176011,-0.07297057,0.036428075,0.09345136,0.012850826,-0.024877667,0.034005955,0.0080092475,0.1077563,0.039091285,0.038820125,0.09617142,-0.0680817,0.036801107,-0.022061361,0.09527271,-0.11305195,0.060656365,0.02001046,0.0016732683,0.07230598,-0.031974755,-0.070807345,-0.008612491,0.0090015875,-0.033036962,-0.029470973,-0.018490769,0.025384583,0.029940795,0.015665404,-0.0701527,0.00497164,0.0044329576,0.037947066,-0.030146988,-0.04251959,0.03428068,0.10165282,0.06641871,0.012876443,-0.012459012,0.098654374,-0.053256568,-0.038558803,-0.0040202728,-0.0008470096,-0.080176674,0.029494686,0.046372328,0.00045495207,0.09573408,-0.036999628,0.08929717,-0.022680974,0.012209245,0.0116851535,-0.058595378,-0.041953243,0.07281455,-0.042787265,-0.027101219,0.026188409,0.011983911,0.0065958253,-0.04983889,-0.031737365,0.025697328,-0.031127336,-0.013639139,0.02470271,-0.00012243867,-0.007509806,-0.035025362,-0.090200886,-0.029202197,-0.02945798,-0.076981865,-0.058862787,-0.0010497366,0.044560254,-0.044455092,-0.10825944,0.06459373,0.05538329,-3.7654597e-34,0.12772472,-0.051591232,0.03635983,-0.078098156,-0.026882034,0.04637165,0.06631303,-0.058045976,0.06524941,0.058014575,0.00064730586,-0.012724004,0.012387581,-0.0140451975,0.022211207,0.05231544,-0.07444105,0.05223751,-0.040497832,0.00025609307,0.023794701,0.09368753,0.047285195,0.04618733,0.066876836,-0.0458523,0.026260884,0.079721,0.04614775,-0.009694494,-0.05538253,-0.033479776,-0.034590382,-0.015199911,-0.074089065,0.016504535,-0.052265424,-0.020229844,-0.019768205,-0.015549377,-0.0022820665,0.058305975,0.039121546,0.02434564,0.04287637,0.027797252,0.007876833,0.006447304,-0.021843988,-0.07549445,-0.0064835935,0.07565519,0.039604746,0.036306687,0.008831143,0.08514708,0.0013368858,0.039449908,-0.07046343,-0.010323982,-0.01757167,-0.0795833,0.04806119,-0.021186572,0.02873246,0.017952893,0.021755094,0.015706796,0.036379002,0.02259955,0.03898168,0.011498568,-0.0014845958,-0.0055603287,-0.033534158,-0.030348657,-0.11789076,0.02056788,0.020575885,-0.066501245,-0.011525003,0.040331487,-0.008911768,-0.054425154,0.024232851,-0.1352026,0.0047686575,0.04711624,0.0133019155,0.057356633,-0.028555626,-0.031871047,-0.067039594,0.008467654,0.074896894,-3.7158763e-08,0.005847899,-0.050339837,0.009666676,-0.047138225,0.03892837,0.011496341,0.04071052,-0.0347975,0.03258434,-0.026342925,-0.0853054,0.07430733,-0.005011019,0.0036170795,0.084924795,0.01735786,-0.08961873,0.041198593,-0.015944887,0.01655463,-0.036591046,-0.058154184,-0.102382295,0.03728581,-0.0055986405,-0.05301796,0.055602726,0.06187599,-0.05205451,0.022416437,0.008842364,0.033291012,-0.035394687,-0.052250687,-0.06715047,0.048850574,0.0023275632,-0.032958496,-0.04256924,0.016723784,-0.009255533,-0.050932523,-0.012241221,0.005606698,-0.07262357,0.07723119,-0.018996552,-0.031873945,0.050333917,0.041587155,0.054447934,-0.038727146,-0.07424579,-0.088757604,-0.06368875,-0.04390942,-0.028174195,-0.046736278,0.021321787,-0.020095356,0.07803438,0.06094354,0.20155038,-0.05987534 +5.4.2.6,"The enzyme requires Mg2+ and phosphorylation of an aspartate residue at the active site. The enzyme is able to autophosphorylate itself with its substrate beta-D-glucose 1-phosphate. Although this is a slow reaction, only a single turnover is required for activation. Once the phosphorylated enzyme is formed, it generates the reaction intermediate beta-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles [4]. cf. EC 5.4.2.2, phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).",384,0.99999994,-0.048991237,-0.05082126,-0.03846283,0.03375903,0.045419734,0.0047987364,0.047374126,-0.0023348695,-0.0039641955,0.033745695,-0.016282791,0.06822733,0.0010179486,0.012859036,-0.041687906,0.0136465905,0.0013384428,-0.009101534,0.012486569,-0.011412599,0.14163876,-0.021797787,0.008615951,0.0014834328,0.103629485,-0.068424605,0.08169501,-0.083056815,0.003377278,-0.027035868,-0.05511528,-0.058150455,0.06107229,0.013856345,-0.025446542,0.12956235,-0.061710685,-0.01558742,-0.03350767,-0.052271903,0.068116985,-0.001901725,0.043414477,-0.041589163,-0.0443987,-0.02259074,0.0025095742,0.03716956,0.046149738,0.0071942275,-0.048806854,-0.059104197,-0.03326428,-0.024057508,-0.0074127857,0.06774708,-0.08199724,0.014547288,-0.033678256,-0.018056368,-0.027793836,0.0053534727,-0.027263287,0.00018114843,0.10117415,-0.0677353,0.025123995,-0.06518132,0.014229413,-0.027063385,-0.024690455,-0.01512855,-0.0054213996,-0.020917902,0.009611483,-0.015074061,-0.03220972,-0.040649585,0.05574168,-0.029654948,0.03808602,-0.051125813,0.07009791,0.0483236,-0.029720511,0.021041594,0.05248524,0.06918793,0.04406973,0.02873692,0.048668705,0.035459135,-0.031847466,-0.03259497,-0.019395227,0.013828601,0.012187927,0.014862773,0.052477665,-0.028334804,0.024576265,0.1119922,-0.012993405,-0.0099340165,-0.027812008,0.036781177,-0.055679996,0.023738693,0.008838007,0.03894894,0.022417756,0.012809355,0.078366265,0.07477162,-0.032713115,0.096562736,-0.058389097,-0.118097454,-0.03801478,-0.018391198,0.023159804,-0.03516488,-0.018462077,0.054905917,-0.064720914,0.1113446,-0.053112328,1.752865e-34,-0.003897432,-0.0013166751,0.017997643,-0.02995152,-0.07590451,0.046757717,-0.08123406,-0.040726922,-0.031117337,-0.042351257,-0.06495671,-0.086667135,0.016787264,0.04589996,0.0032127248,-0.06906244,0.044880554,0.037375163,0.14992888,0.020797422,-0.010129915,0.05125694,-0.0682605,-0.030424979,0.012798714,0.10165813,-0.030294616,0.07029098,-0.00053759577,0.0154779395,0.060668554,-0.04766093,-0.08136977,0.033081114,0.0143661415,-0.081668854,-0.06028035,0.0030679337,-0.014594965,-0.008151223,-0.00054792647,-0.025898194,-0.03334226,-0.004672818,0.02017926,-0.08062826,-0.009274868,0.05241151,0.0548055,0.13078888,0.053647313,0.020111477,0.0502821,-0.023858149,-0.037046462,0.05828031,-0.022330206,-0.06411118,0.099090785,0.045671005,0.040970884,0.02530736,-0.025370294,0.06734474,0.054355614,0.050463483,-0.05647463,-0.07391451,-0.039933756,0.07452196,-0.025293278,-0.058211196,0.043379232,-0.019662887,-0.03183147,-0.026212774,0.0044316775,0.00404654,-0.05204436,-0.026682397,0.028963514,0.013829771,-0.010273764,0.0052679745,-0.022858571,0.013878185,0.046657756,-0.062689066,-0.07252495,-0.010406557,0.011577706,-0.051553898,-0.062057726,0.08351377,0.053691976,-2.23707e-33,0.14974272,-0.082513325,0.09670081,-0.06580662,-0.03233294,0.04470556,0.11219181,-0.077394865,0.05657397,0.026019657,-0.017945845,0.021641683,-0.014972533,-0.046708193,0.0046353177,-0.013318452,-0.0022885702,0.075533666,-0.024088832,-0.0010831147,0.02939418,0.13084699,0.010458121,0.06149834,0.055162948,-0.056750745,-0.005816391,0.05895898,-0.021782594,0.07236593,-0.014724379,0.036466934,0.016919458,-0.08082338,-0.0691147,0.031082578,-0.056238994,-0.031896558,0.008992969,0.075757876,0.035806872,0.06956208,0.024803596,-0.0093031665,0.05131776,0.034111753,-0.032954406,0.0646164,-0.016527025,-0.07177517,-0.012636724,-0.0009527057,0.0006452454,0.00364465,0.06446613,0.05604119,-0.0065058395,0.07466777,-0.03707964,-0.048714172,-0.033602156,-0.07285869,0.084320016,-0.05943682,0.045603737,0.023627112,0.013924925,0.005488029,0.0020626504,0.11618021,0.010501083,0.041241776,0.001712048,0.033918902,0.0024171446,-0.022267343,-0.06433948,-0.007884463,0.045892533,-0.08707174,-0.06250084,0.08765267,-0.037389077,-0.038985547,-0.015566277,-0.12126418,-0.008198634,0.070221424,0.055619936,0.014620427,-0.052267365,-0.07430994,-0.035519328,0.002703485,0.030138299,-4.3255064e-08,0.017268213,-0.028367687,0.043897554,-0.052404854,0.056492023,0.023416251,0.01498698,-0.06105895,0.047579363,-0.05153774,-0.0326041,0.022485297,0.0031893286,-0.014405531,-0.005701669,0.0042494605,-0.075252645,0.045384195,-0.053312346,-0.023685021,-0.020957148,-0.04933691,-0.11547984,0.04877225,0.020306904,-0.059237108,0.050521705,0.05202298,-0.085419975,-0.0051125055,-0.009701466,0.014751352,-0.027686017,-0.08173934,-0.060118698,0.03020902,-0.04686514,0.012780607,-0.022412889,-0.014224588,-0.008187822,-0.050044563,0.068373054,0.0006974958,-0.08984225,0.054410525,-0.017050868,-0.052970804,-0.016569093,0.06313847,0.04088044,-0.055712562,-0.11408075,-0.109127976,-0.024812471,-0.027841633,-0.011231722,-0.09230395,-0.007229102,-0.060593985,0.05335481,0.08552177,0.12826902,-0.09619731 +5.4.2.7,"Also converts 2-deoxy-alpha-D-ribose 1-phosphate into 2-deoxy-D-ribose 5-phosphate. alpha-D-Ribose 1,5-bisphosphate, 2-deoxy-alpha-D-ribose 1,5-bisphosphate, or alpha-D-glucose 1,6-bisphosphate can act as cofactor.",384,1.0,-0.0031264003,-0.064660154,-0.040576585,-0.055429433,0.025955092,-0.02295254,-0.009734872,-0.033778537,-0.0209344,0.09684017,0.009061862,0.026708813,-0.06658514,0.015614344,-0.0070131333,-0.008438418,-0.019608479,0.05528787,0.043541793,0.0037003048,0.10576645,0.037884958,-0.023512973,-0.005844874,0.04545404,0.0214438,0.0091071185,-0.034405977,0.007867704,-0.056725834,-0.017106008,-0.006458879,-0.008132844,-0.004260495,0.029782832,0.06940873,0.011660385,-0.017244576,0.006762341,0.07347331,0.0432073,0.036830615,0.06395131,0.027468171,-0.042975992,-0.0359293,-0.106634654,0.08016081,0.024475273,-0.017330313,-0.035751477,-0.01798018,-0.14301461,-0.048804417,0.03937496,0.064698726,0.018135494,0.014043929,-0.0360298,0.014013539,-0.010169694,-0.02943119,0.01909115,0.03689597,0.10223978,-0.037164576,0.025965232,-0.03397845,-0.054986227,-0.043721,-0.08889523,-0.055193324,0.008523714,-0.04108328,0.0068837986,0.031135047,-0.08954833,-0.051506344,0.06725807,-0.021859897,0.042337388,0.026163861,0.08860347,0.008019072,-0.032315962,0.04525717,-0.029741816,0.0037691277,-0.0059016254,0.0071795452,-0.011533422,-0.0018530356,0.1315359,-0.015676472,-0.05824567,0.026058482,-0.0026614387,0.09491333,0.01889252,-0.056236614,-0.0124767795,0.087388806,-0.032484934,-0.082625665,-0.0838913,0.009205913,0.0043805405,0.0656133,0.029619036,0.0480153,-0.042739622,0.029320527,0.04348768,-0.008392671,-0.023989184,0.10641606,0.00692734,-0.038349822,0.050359458,-0.054815337,0.04625478,-0.070110105,0.018988976,0.04637327,-0.06864625,0.07554701,-0.052258313,1.0213712e-33,0.074939795,0.07296557,0.0757846,0.056420557,-0.08603494,0.0004108378,-0.13076127,-0.07704327,-0.033437435,-0.0013291221,-0.07362965,2.0288926e-05,0.07624817,0.0015675917,-0.017103601,-0.07636755,-0.05172762,0.037727494,0.04569832,0.046304345,0.013543173,0.15839843,-0.06341778,0.04843326,0.03414434,0.031194523,-0.06556121,0.03779932,0.016185174,-0.017066937,-0.016814316,-0.02207825,-0.08662505,0.02816561,-0.010912398,-0.07659865,-0.047744688,-0.0015124615,0.019780677,-0.011465005,0.039122015,-0.043271076,-0.00183772,-0.009233887,0.041302606,-0.07427186,0.026495816,0.0075433822,-0.00592498,0.05080243,0.002314003,0.002350059,0.016279455,0.009702361,-0.058855254,-0.002690167,0.038457267,-0.050880298,0.090415195,0.049769495,-0.001590168,0.027169757,0.01730117,0.0057630483,0.00029107748,-0.023131957,-0.009610538,-0.1179544,0.0157357,0.09193887,-0.0024024628,-0.037364215,0.009899094,-0.014356457,0.018701354,-0.040454857,0.03659349,0.0011692888,-0.043264925,0.0011446622,0.0028161579,-0.020722639,-0.002896993,-0.095922105,-0.017381595,0.038778894,-0.016340403,-0.10390832,-0.033140667,0.004286551,0.03406673,-0.04294121,-0.02979075,0.00539072,0.016077362,-1.1457243e-33,0.04102022,-0.08674922,0.044015698,-0.06303867,-0.08312573,0.028392999,0.10927009,-0.12094787,0.13812469,-0.0011457328,0.06551361,0.06802392,0.023448583,-0.044856306,0.017877916,0.01906547,0.03355452,0.084633656,-0.0073223496,0.005688173,0.079545744,0.08384948,0.0012625733,0.04632889,0.07906025,0.039229166,0.057879664,-0.010906774,0.07210625,0.0007739173,0.0064957077,-0.028912863,0.05533672,0.030114133,-0.123431444,-0.011859427,-0.04853451,0.03266976,-0.093802564,-0.020368509,-0.11328188,0.082661025,0.057038642,0.035360206,0.0403594,-0.033282347,0.0052535348,0.004413184,-0.026081856,0.057969358,-0.0009980147,0.015664166,-0.047991067,0.010958026,-0.024507008,0.021153597,0.027002655,0.048114106,-0.045650937,0.014017111,-0.016438708,0.01407348,0.042202745,-0.045852534,0.09381256,0.01847277,0.0058807484,0.0069409125,0.007843654,0.027939474,0.030816948,0.051218998,-0.018851608,0.030614192,0.045404952,-0.082981676,-0.06540569,0.011172052,-0.019619416,-0.013556153,-0.068975344,0.033973016,0.009475662,0.0073384955,-0.0082045635,-0.13509338,0.051046886,0.07053444,0.021053623,0.06255839,-0.07566402,-0.010072508,0.03271857,0.028634131,0.0926772,-4.1546727e-08,-0.028764926,0.016018085,0.027241182,-0.029980186,0.010844287,0.016913608,-0.0043756054,-0.050249018,0.09304216,-0.060812335,-0.03944568,0.11305461,0.04747054,0.021059781,0.069191135,0.0066475486,-0.06645026,-0.01407176,-0.029771205,-0.0010312899,-0.005123866,-0.04593186,-0.08199268,0.06722484,-0.060552083,-0.045548126,0.017451448,0.019578103,0.03284653,-0.012025066,-0.05385329,0.010599028,0.033389185,-0.15490437,-0.059474,0.034090694,0.0155000845,-0.017904691,-0.014058318,0.05069699,-0.023465294,-0.077087425,-0.019258888,0.018370101,-0.07700284,0.0015030466,0.0037661474,0.008825123,-0.0005726727,0.020135993,0.06861223,0.013112598,-0.1018489,-0.09896291,-0.061833788,-0.02824546,-0.023809843,-0.006367799,0.083797365,-0.031108113,0.041172717,0.049541272,0.16882709,-0.06238222 +5.4.2.8,"alpha-D-Mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor.",384,1.0,0.006767225,-0.07974402,-0.09440304,-0.06368753,0.005075916,0.06400521,0.06604414,0.002055209,-0.016892523,0.090502016,0.03628869,-0.02505152,-0.1080375,0.04413628,0.024744788,-0.04531364,-0.034777313,-0.008963366,0.06391461,0.0117321005,0.083969906,0.030659402,0.022382399,0.004231735,0.026008423,0.02109869,0.026165286,-0.052033585,0.03923575,-0.064582214,-0.061100088,0.014908773,0.011184419,0.002106767,0.049618818,0.08931377,0.023380099,-0.06355666,0.01836689,0.02589726,0.061600007,0.0057939547,0.086558506,-0.0020857698,-0.024573743,-0.0044061434,-0.07136931,0.054880302,0.023683205,-0.008627407,-0.026976569,-0.03662061,-0.062071048,0.015754085,-0.00072717667,0.043861628,-0.02907403,-0.0045015863,0.009451561,0.01611588,-0.013152652,-0.031460907,0.07547456,0.01828145,0.10369878,-0.036039792,-0.007735807,-0.06455502,-0.01714571,-0.006859256,-0.065096065,-0.023689473,-0.01777995,-0.04598206,0.0018319233,0.06185161,-0.07090147,-0.09441578,0.07651896,-0.027531838,0.012526731,0.051014815,0.11598328,0.02698401,-0.02933461,-0.025270782,0.04248773,0.009999765,-0.016809035,0.0014081575,-0.013711106,0.008260576,0.12370656,-0.025789566,-0.07823539,0.040928427,0.0094911745,0.047977768,0.03512787,-0.036700644,0.025635866,0.07373591,-0.026419278,0.01818651,-0.058314104,0.009482326,-0.01762396,0.02717611,0.0273549,0.036836922,-0.07285644,0.019951876,0.049705047,-0.01678787,-0.079422496,0.042136174,0.00724095,-0.03996523,0.05920856,-0.022807771,0.030554283,-0.072099045,-0.021632193,0.031575922,-0.026987193,0.059234202,-0.06352062,-2.3867823e-34,0.09611381,0.027734006,0.08783482,-0.020848813,-0.054041598,-0.027822653,-0.08891172,-0.067099534,-0.054953262,-0.019943122,-0.024609609,0.03057836,0.016051296,0.054824363,-0.05392112,-0.0071028783,-0.0679342,0.015784597,0.029815862,-0.039873805,-0.02160198,0.17026788,-0.040642563,-0.0037202921,0.035472836,0.023731427,-0.091407716,0.056841496,-0.02387011,-0.009642734,0.04666494,-0.01596151,-0.06578956,0.0642019,0.0047018044,-0.062344458,-0.05268223,-0.011606922,-0.041021887,-0.041319814,0.05892757,-0.008353773,-0.0039121336,-0.051617954,0.033222027,-0.092997834,0.021702534,0.005272346,-0.005797752,0.062110018,-0.0063736173,-0.015270086,0.019559825,0.026788184,-0.02122649,0.008846896,-0.007246678,-0.038096465,0.045740273,0.05687506,-0.021031069,0.026799776,0.009949233,0.039186634,-0.021384645,-0.009052307,-0.052041315,-0.059060514,0.027677296,0.05171946,-0.028184485,-0.041973233,-0.0040632715,-0.004985488,-0.015215091,-0.04576236,0.018792888,-0.0044330657,-0.0981094,0.015443419,0.054480262,-0.035296876,0.014622845,-0.07190434,-0.12368723,0.03460602,-0.03821898,-0.0976134,-0.05444481,-0.034024194,-0.00913087,-0.012423648,-0.038823757,0.034734048,-0.04105675,-1.5737853e-33,0.067445494,-0.086036496,0.0764655,-0.07156383,-0.06614346,0.02477899,0.17589648,-0.12857416,0.09510527,-0.0035291156,0.03520832,0.055062223,0.035409003,-0.039308794,0.039701186,0.049806572,0.017887034,0.08795051,0.025912374,-0.0058549726,-0.037421525,0.10846674,-0.01000531,0.05288239,0.07737348,0.02689052,0.029730879,-0.04518682,0.016993372,0.020301113,-0.018859195,-0.031930123,0.059752904,-0.020393338,-0.062082056,-0.088052236,-0.04414201,-0.009672083,-0.0913264,-0.059525784,-0.045676824,0.07198424,0.0734588,0.026924932,0.095441625,-0.036360253,-0.00058023847,0.03807565,-0.060073752,0.12212665,-0.053269755,-0.02728882,-0.04830821,-0.026675291,0.016099645,0.06351293,0.0029067637,0.02995988,-0.04619394,0.030804612,0.023482665,0.01649713,0.036691453,-0.024973098,0.10842028,0.029634526,-0.019487783,7.271856e-05,0.062192976,0.05274717,0.05668682,0.11262615,-0.009790239,-0.017945895,0.026569955,-0.037672725,-0.082654014,-0.0013358595,-0.0076062726,-0.01301634,-0.07180964,0.06797281,-0.023643875,0.014983847,-0.0014715041,-0.03757966,0.028162846,0.05989484,0.033035766,0.07539316,-0.07554476,-0.0424009,0.0106851775,0.038749825,0.03598705,-3.0114315e-08,0.06181336,-0.017676802,0.056093346,-0.055417806,0.01196646,0.038386673,0.011036412,-0.08260091,0.049721066,-0.016087113,-0.00716099,0.083395,0.076645106,0.010512962,0.02349823,-0.07666622,-0.08400264,-0.015938727,-0.07608262,0.019362826,-0.049037334,-0.04027535,-0.055083167,0.10107097,-0.033731617,-0.03366725,0.03992355,0.063950345,-0.03213825,0.03356945,-0.018187573,0.007049519,0.019772545,-0.13258801,-0.023969378,0.048681032,0.014846967,-0.04477888,-0.06174582,0.041754644,0.011449841,-0.062621996,0.0110142585,-0.015686966,-0.043437917,0.052583482,-0.03555278,-0.015579529,-0.009222694,0.03471985,0.011053605,0.0097108,-0.13354258,-0.044117182,-0.043318264,-0.05525528,-0.014976315,-0.014499733,0.04795145,-0.043597925,0.09582019,-0.01892019,0.15496367,-0.064901575 +5.4.2.9,"Involved in the biosynthesis of the C-P bond, although the equilibrium greatly favours phosphoenolpyruvate.",384,0.99999994,-0.039637394,0.030827131,-0.096640915,0.022210216,0.016916478,0.10323124,-0.04772625,0.050852165,0.05743489,0.09576022,-0.03533974,-0.010450001,-0.109570615,0.024325453,0.0048368163,0.013137318,-0.061806545,-0.016430626,0.05594368,0.029301085,0.06977188,-0.025295991,0.033121757,-0.0025128215,0.0052017905,-0.0040913383,0.0667322,-0.033770867,-0.0030826323,-0.006347698,-0.055286918,-0.023744209,0.056684885,-0.057846952,0.06977767,0.1653954,-0.08747884,-0.063388884,0.047054227,-0.0149334045,0.08092621,0.0391901,-0.03695736,0.08329747,-0.037680823,0.05897403,-0.041446146,0.065703504,-0.023486724,-0.056749318,-0.049311884,0.055696856,-0.09890571,0.00801215,-0.04604684,0.1262462,-0.070639685,0.028998991,-0.014464932,-0.08393388,-0.017893663,0.008482997,0.05529143,0.06479315,0.031053927,-0.0454753,0.083437435,-0.039774716,0.02882384,-0.06419392,-0.10877632,-0.0061670537,0.052869543,-0.09197077,0.033592746,0.03299613,-0.011971616,0.023419265,-0.03521532,-0.019058516,0.034871917,-0.020696137,-0.06526542,0.025166288,0.010773739,-0.012275128,0.026204396,-0.08962558,0.02711934,0.040758405,-0.036179516,-0.019944178,-0.0016823607,-0.029928101,-0.025217239,0.027054673,0.0888078,-0.016564861,0.016152564,-0.04862463,0.012544209,0.092593364,-0.04053882,-0.014033258,-0.034016356,-0.01222232,-0.04377056,0.025590278,0.051967658,0.074795604,0.021491611,0.07149919,0.034116276,-0.06626305,-0.008854799,0.059802312,-0.026060876,-0.0626265,-0.029051566,0.024113419,0.022546653,-0.07011209,-0.050632175,0.032830816,-0.15575431,0.023178168,-0.06870857,-3.8010283e-34,0.056754515,0.020000793,0.04485668,-0.054562148,0.025337566,-0.0025469027,-0.11181296,-0.036693655,-0.062078945,-0.047057245,-0.079864785,-0.120119855,0.1121251,-0.007670785,-0.07902198,0.032925576,-0.08948574,0.033077434,0.08527563,-0.0200007,-0.024560407,0.04683023,0.024984712,0.060374122,0.01620712,0.045428324,-0.051165268,0.072410226,0.017477203,-0.03650319,0.07389464,-0.011615867,-0.029299961,-0.014781418,0.033791542,-0.025760917,-0.0950581,-0.087015875,-0.010908965,0.028139276,-0.064821735,-0.0065366062,0.008872248,-0.01810365,0.02798928,-0.086226664,-0.022983812,0.044032913,0.024100523,0.028796993,0.04538746,-0.015581585,0.07100354,0.053093854,-0.04790845,0.003531101,-0.011370466,-0.084792666,-0.027892685,0.024889544,0.055875015,0.06592778,0.035580162,-0.05549751,-0.035417475,0.037491154,-0.07736529,0.016498642,-0.063408785,0.023741927,-0.04250006,-0.0350184,0.044819005,-0.04336973,-0.0050530373,0.037560556,-0.050477147,0.014487078,-0.03710518,-0.021095078,0.062421445,-0.0029774175,0.07631424,0.007167591,-0.011715395,-0.059161466,-0.050770156,-0.06888879,0.07149332,0.08456736,-0.0040019257,-0.06511017,0.027618986,0.03085982,-0.0030362206,-1.898651e-33,0.09318733,-0.05644122,-0.043865725,-0.050827883,-0.01803235,0.020521471,-0.027168829,-0.0765033,-0.04938415,-0.045658,0.0409186,-0.012762922,-0.014872882,-0.023831278,0.03874969,0.03305405,0.04579841,0.11976687,0.03546589,0.057168793,0.03901082,0.033750013,-0.042571332,0.054483324,0.04438638,0.019597406,0.00092899083,0.03380579,0.015843242,0.04202069,-0.0040673944,0.0016870564,-0.11216995,0.008147176,0.029658688,0.06090534,-0.121232614,-0.004308746,0.048405405,0.095077835,0.05149168,0.020418186,0.06400637,-0.018417008,0.07597832,0.0037298342,-0.013629715,-0.045717373,-0.009382508,0.027118905,0.008033611,0.047374718,-0.043563563,-0.0073202546,0.04774106,0.092443444,-0.039842974,0.05290877,0.027340781,-0.07589615,-0.051809806,-0.07946282,0.021934355,-0.002550267,-0.017716145,0.026310498,-0.04236121,0.027709411,0.030397361,0.012105311,0.0124387145,0.09944106,0.004444188,0.04290281,-0.024397625,-0.019792136,-0.062282503,-0.050603285,0.033520184,0.022244982,-0.030002318,0.037659988,0.0626239,-0.1278594,-0.07504412,-0.050679527,0.0097437175,-0.025751969,-0.00644101,-0.014510578,0.016280081,-0.05525825,0.010600311,-0.0060038273,0.12529705,-2.7008904e-08,0.06866515,0.01826079,0.036281087,0.005227397,-0.0017847597,-0.038012497,0.026968073,-0.060741834,-0.0020499907,-0.011392351,0.011603563,0.03278434,0.070127815,-0.019568602,0.054881737,0.01738201,-0.08872531,0.0033191547,-0.027634978,0.03353877,-0.12082714,-0.019267997,-0.08547171,0.05462925,0.057087474,-0.081727475,0.056963112,-0.018990023,-0.042610142,0.009417592,0.046873745,-0.01390085,0.015226931,-0.027628088,-0.00591425,0.017211948,-0.027282696,0.009432872,0.00858458,0.010856007,-0.022932252,-0.056460943,-0.0039708135,0.0748764,0.03294104,0.06976475,1.6595422e-06,0.05619194,-0.06142095,0.0021506737,0.019923335,0.0039281053,-0.06548004,-0.06817805,-0.03185029,-0.035184138,-3.0244813e-05,0.02432206,-0.02717634,-0.043328583,-0.026412223,0.026518136,0.120498136,-0.08816168 +5.4.2.10,"The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6-bisphosphate, which is an intermediate in the reaction, alpha-D-glucose 1,6-bisphosphate or ATP. It can also catalyse the interconversion of alpha-D-glucose 1-phosphate and glucose 6-phosphate, although at a much lower rate.",384,0.99999994,-0.06399902,-0.041402753,-0.12048563,-0.0051077907,-0.025192074,0.046156786,-0.023313958,0.020674368,0.030460168,0.050499834,-0.05139697,0.05823045,4.602088e-05,0.033172123,-0.06657334,0.006377544,-0.05443918,-0.02631537,0.02658293,-0.050269995,0.08664511,-0.0065482813,-0.058147546,-0.03602931,0.0715982,-0.008518069,0.10767177,-0.042480156,-0.03076868,-0.045799594,-0.052672096,-0.1056778,0.044664606,-0.017317219,0.09380244,0.15086442,0.0040394296,0.020624032,0.095511645,-0.026536394,0.032821897,0.013774193,0.0066082953,-0.013627212,0.0040797973,-0.022686083,-0.05794557,0.07924269,0.031655923,-0.065338925,-0.017801935,0.014594209,-0.015952857,0.004084746,0.07790765,0.050220795,-0.036203187,0.014176446,0.03184908,0.00731667,-0.0040267273,-0.00809566,0.033474024,0.017877076,0.0023626173,-0.14515954,0.06462475,-0.032195535,-0.026336601,0.013826626,-0.051804636,-0.012005439,0.004666169,-0.008118306,0.048538182,-0.018149791,-0.061685003,-0.031696647,0.041386597,-0.025873372,0.02749332,-0.03797478,0.05079582,0.10954657,0.0046901056,-0.029699279,0.04660932,0.012831063,0.07423606,0.052745596,-0.0109336395,-0.10064509,0.03106489,-0.060220215,-0.07569717,-0.04644257,0.024442961,-0.045474734,0.035128698,-0.057801094,-0.0070621492,0.029537134,-0.0032172147,-0.04303282,0.003944418,0.056962613,-0.013959904,0.13818218,0.015921736,0.03278121,-0.050108176,0.028456332,0.05508816,0.033934783,-0.0838427,0.087409794,-0.0048527634,-0.10540517,-0.023855703,-0.028695794,0.012070373,-0.0432745,0.021269439,0.06800311,-0.080258,0.051500082,-0.017776895,2.0085683e-33,0.049718793,0.025459494,-0.018188655,-0.057631448,0.017684419,0.010951728,-0.059139326,-0.062394273,-0.004358582,-0.018869093,-0.034618128,-0.07594951,0.06099493,0.07559595,-0.045773547,0.052230716,-0.050262317,0.014949236,0.077488445,0.031196095,-0.014767801,0.06462035,-0.0062629334,-0.018381732,0.03593614,0.081174105,-0.045962118,0.07613312,-0.0044866903,0.0012092513,0.005022633,-0.040854238,-0.07774922,0.025941182,0.045869637,-0.02386744,-0.03278925,-0.034014933,0.04690253,0.022647986,0.031250954,0.03434405,-0.028869653,-0.03543816,0.022832144,0.04051547,-0.037383087,0.01955227,0.0020425944,0.09797593,0.038769934,-0.024063518,0.08607887,-0.02784291,-0.05510464,0.026728528,-0.022929963,-0.096525475,0.06534931,0.07866334,0.029174386,0.047729284,-0.013447856,0.02224406,0.012631876,-0.013986964,-0.028523622,-0.03188548,0.0036835577,0.07336027,-0.07864896,-0.02768848,0.041724034,0.020801159,-0.036501355,-0.04563113,-0.021346373,0.015137239,-0.015640741,0.005979801,0.020731047,0.023707908,0.024728712,-0.026163198,-0.009911954,0.02790279,-0.049660653,-0.08427031,-0.046984002,0.05029124,-0.0024839938,-0.08854103,-0.067573436,0.106385,-0.010379481,-4.6026907e-33,0.14075802,-0.113513894,0.11418745,-0.08686556,-0.08299146,0.07392106,0.037988063,-0.056539793,0.0677881,0.004048684,-0.033516876,0.02172459,-0.013073536,0.013795407,0.013341492,-0.030270914,-0.008920312,0.08747342,-0.06796238,-0.003935545,-0.014792903,0.07557084,-0.040372334,0.03196844,0.06211115,-0.027388185,-0.045094,0.069002666,-0.0035937396,0.028340558,0.014071277,-0.0064637875,-0.06324302,-0.0656436,-0.05899916,0.050405506,-0.015285764,0.0010994112,-0.039249007,-0.010655737,0.04476043,0.09831846,-0.04155177,0.002142076,0.03850157,0.05757338,-0.054344643,0.022464419,-0.062439002,-0.036157183,0.004586676,0.0010970624,0.03352871,0.028512556,0.013711936,0.015783345,0.038266473,0.05583461,-0.008229437,-0.029592484,-0.023993514,-0.08005174,0.022112686,-0.029160226,0.05998145,0.0543211,0.0035621333,0.01656518,0.014726461,0.029126765,-0.0041869665,0.03438782,0.021699432,0.07550915,-0.011886696,0.00034199154,-0.08986939,-0.091540925,0.03505457,-0.018520892,-0.02848596,0.043006122,-0.04383285,-0.024228206,-0.040766075,-0.04166061,0.06317733,0.104927704,0.010031943,0.048826896,-0.019346243,-0.047670033,-0.023478609,-0.0037074771,0.018150423,-4.6905587e-08,0.041552052,-0.039217424,0.01191968,-0.06882909,-0.04462703,-0.0004058897,-0.0088662105,0.006799717,0.07311616,-0.09083667,-0.015345304,0.11416029,0.032554474,-0.0069564707,-0.04018529,0.041496955,-0.07033855,-0.0077539003,0.0021264425,0.015187555,-0.09619169,-0.033920694,-0.12762271,0.07152862,0.0581389,-0.10201489,0.06045164,0.029992698,-0.03929053,-0.017726533,-0.042231966,7.936506e-05,-0.04034664,-0.089625165,-0.0047224923,0.007538107,-0.04159652,-0.0796459,0.042012256,-0.011566473,0.06031394,0.010316656,-0.024132635,0.0114073735,-0.027868727,0.08510318,-0.03909673,-0.031639475,-0.06978682,0.0043084864,0.018048476,-0.030585779,-0.042352382,-0.12557006,-0.069048814,-0.021603776,-0.05632055,-0.10132014,0.015112998,-0.00445434,0.018280633,0.049215242,0.19195743,-0.05784654 +5.4.3.2,"This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule. Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions. A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron-sulfur cluster. S-adenosyl-L-methionine is regenerated at the end of the reaction.",384,0.99999994,-0.05921289,-0.09286448,-0.08544303,0.07242452,0.08443919,0.016139148,-0.09228746,0.0070213685,0.0112072425,0.03357216,0.01720789,0.0739158,-0.02302722,0.024643932,-0.0045057917,0.114867605,-0.09910848,0.025147894,-0.015504642,-0.030754996,0.015994737,-0.0008944329,-0.02881803,-0.0097633805,0.08838841,0.042582545,0.08407763,-0.00060535985,-0.08687266,-0.034356095,0.043802515,-0.031257678,0.07614848,-0.007950229,-0.017180007,0.17435236,-0.053848583,0.007650111,0.040648945,-0.0009016194,0.002826037,-0.009830184,-0.011724936,-0.029932197,-0.0014681779,-0.049255695,-0.052323315,0.02963805,0.053319026,-0.030318279,-0.055583876,-0.000746295,-0.03923141,-0.018185962,0.014296969,0.036107432,0.023785569,-0.0072684926,-0.010828033,-0.025942687,0.09904104,-0.06981898,-0.03953251,-0.03753382,-0.03382454,-0.01664926,0.09765491,-0.04259674,0.06955254,-0.035239514,-0.046102505,-0.0012798948,0.020521544,-0.003890589,-0.07593069,-0.004950576,-0.01936592,-0.061781656,0.040639155,0.009774555,0.06263835,0.0016153142,0.0453778,0.022876227,0.09064698,0.06422552,-0.020037265,-0.04552304,0.034159616,0.014395909,-0.08965188,0.010122882,-0.07939982,-0.076969564,-0.014958376,-0.0072143143,0.023396846,0.03975246,-0.08412096,-0.001309962,-0.013326898,0.0680224,-0.09588794,-0.07296198,-0.05321596,-0.052256912,-0.01177909,0.05384931,-0.023533486,0.047159605,0.05726961,0.04715085,0.051253095,-0.009181329,-0.017295625,0.117975384,0.013881402,-0.049952287,-0.06740837,0.041848987,0.037823167,0.0386479,0.034627333,0.03462806,-0.025817765,-0.019042933,-0.05996534,2.7136577e-33,0.07861544,0.10498332,0.02061787,0.05980593,0.0020123066,-0.015046653,-0.13196863,0.01111921,-0.0039647925,-0.0027247756,-0.053886626,-0.037354816,0.09046786,-0.06497691,-0.096671894,-0.053438593,-0.045853633,0.020092474,0.05564751,-0.028663378,-0.08142419,-0.019683154,-0.0992538,0.023960862,-0.06014618,0.05079557,0.0076535433,0.019233802,0.02678532,0.035315398,-0.070117846,-0.002737445,-0.0741838,0.010573549,0.0074447007,0.0023758619,-0.08450584,-0.08817377,0.057889126,0.028225657,0.037117977,0.010825805,0.018211097,-0.0044931034,0.039468355,-0.010534526,-0.059039585,0.066095844,0.026845403,0.093663745,0.035188038,-0.044885773,0.12669127,-0.012055839,-0.118826754,-0.0272207,-0.02218097,-0.06553477,0.033720776,0.13447484,0.045305233,-0.01761641,-0.05404844,0.02667207,-0.016009847,-0.017126895,-0.045461856,-0.011957307,-0.0021441814,0.089646466,0.056054685,0.01691286,0.080118366,0.088991486,-0.04474661,0.010388625,0.05972844,0.13402866,0.026397444,0.011625471,-0.022176115,-0.04014689,-0.06010808,-0.04650153,0.0059882463,-0.00061972847,-0.026891496,-0.046380106,-0.0048091114,-0.005520872,0.0050722416,-0.089638814,-0.021096127,0.0087145725,0.029705388,-3.9053915e-33,0.036941353,-0.041338675,-0.021160498,-0.04928497,-0.032721654,0.07642614,0.003447428,0.017047519,0.013289782,0.00800419,0.082736015,-0.012040236,0.012548637,-0.07677495,0.056993082,0.011329733,0.030973997,0.017061293,0.0034283604,0.011042713,0.0680633,0.06608733,0.018503804,0.009602323,0.11395495,-0.023318095,0.0039039652,0.024586763,0.053837605,0.09419716,0.04849282,-0.023040395,-0.05809583,-0.0036029886,-0.0037924591,0.06700187,-0.062689014,0.01692422,-0.020341,0.013918881,0.020374183,0.035800565,0.01291532,0.17713647,0.04575176,0.020496922,-0.06529676,0.022449315,0.005604455,-0.1317619,0.033873495,-0.03691115,-0.015813567,-0.046391517,-0.030754553,0.08355087,0.017301442,0.0062312884,-0.092056885,-0.036946706,-0.06828077,-0.0765446,0.029286921,0.01617766,0.0039532995,0.016656127,0.0095575005,0.008288646,-0.017323213,0.01852526,-0.019518785,0.022932354,0.011722421,0.059260096,-0.068929724,-0.02775212,-0.07092403,0.027849535,0.013263376,-0.0052486574,-0.017521864,-0.0022362391,-0.02521525,-0.0888847,0.008514848,-0.08518118,0.03201372,0.103114665,0.008022473,-0.013078401,-0.0729555,-0.001956949,-0.0622884,0.0094934255,0.009914968,-4.399778e-08,0.027008649,-0.06578206,0.042066306,-0.031102514,0.007853869,0.0660366,0.022077184,-0.0051025944,0.012898855,-0.040723078,-0.047258496,0.11400068,-0.0019244655,0.02444247,-0.008514892,0.033216644,-0.03429687,0.045629375,-0.011158189,-0.018166598,-0.04375361,-0.02954466,-0.04804159,0.02010112,-0.0063351975,-0.01295945,0.07526222,0.01580883,0.0047723926,-0.062045995,0.08226608,-0.021564258,-0.07009044,0.030665172,-0.14739318,-0.021171369,-0.059271954,-0.008830958,-0.008733636,0.051929686,-0.043614592,-0.0337983,-0.05158777,0.086141884,-0.07019914,0.024437206,-0.034308866,-0.015204371,-0.020723281,0.020565344,0.028442059,-0.021677576,-0.037783775,-0.05218259,-0.09040147,0.034474198,0.021420773,-0.014371635,0.047520187,-0.039141495,-0.029431473,0.026194276,0.096993126,-0.0046887132 +5.4.3.3,"This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It requires pyridoxal 5'-phosphate and adenosylcobalamin for activity. A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of adenosylcobalamin, which is regenerated at the end of the reaction.",384,1.0,-0.11047641,-0.081786156,-0.11533569,0.0072596376,0.022491092,0.0020473965,-0.05794785,-0.022581909,0.028338868,0.03432549,0.050285626,0.062204264,-0.047133658,0.016646903,0.011502362,0.13173118,-0.0813646,0.029112272,-0.04089202,-0.07430094,0.032835122,0.019308604,0.006508778,-0.0052371053,0.06181885,0.027958294,0.09222475,0.018095886,-0.025106335,-0.03584862,0.0872276,-0.0074491105,0.07080339,-0.016926544,-0.0376365,0.13389675,-0.08063973,-0.002925404,0.040318005,0.00028571632,0.009331448,0.0055211917,-0.03047608,-0.011334143,-0.028136035,-0.044643946,-0.015088131,0.0737617,0.057238605,0.013317455,-0.07481583,-0.012430488,-0.045736775,-0.04906095,0.021018809,0.036759425,-0.0203264,-0.02013737,-0.0062694596,-0.010655542,0.067108,-0.027910642,-0.07259113,-0.018508356,-0.049124744,0.005240476,0.107243106,-0.04649779,0.032488566,-0.054584745,-0.03829229,-0.060968082,0.019890366,-0.005285116,-0.0750406,0.016874446,-0.055625115,-0.0816109,-0.0067343744,0.022348918,0.036617417,-0.0001808333,0.015737398,0.079972394,0.09345809,0.021897567,0.013034795,0.015548901,0.019518165,0.029940754,-0.039858874,-0.013680058,-0.025346002,-0.035798628,-0.0147588,0.012078073,0.014531877,0.018286867,-0.066817,-0.01947631,-0.04741354,0.06444565,-0.020034451,-0.060758214,-0.06619982,-0.038600434,-0.035589255,0.080136664,0.002258498,0.035116374,-0.0057033263,0.056780785,-0.009369876,-0.0060598315,0.018078,0.09036144,0.016060278,-0.06409849,-0.091951296,0.039725363,0.040880557,0.02977299,0.0008994292,0.06541711,-0.048843816,0.0039371364,-0.069093265,2.6904526e-33,0.06559385,0.077531815,0.04716198,0.030287039,-0.019821836,0.01691542,-0.12270756,-0.005081818,-0.0090601295,-0.009320224,-0.035355758,-0.031752177,0.1022846,-0.028148282,-0.07085111,-0.07098982,-0.05064793,-0.006731694,0.053950716,0.024026526,-0.06689671,0.021547787,-0.1257832,0.03458976,-0.054990686,0.10596086,0.049097043,0.046989948,0.021829018,0.027711174,-0.06341662,-0.053403147,-0.109087534,-0.033772267,-0.00052776025,-0.007305827,-0.06252053,-0.06856775,0.02731656,0.06687659,0.012218662,-0.034852445,-0.0027198668,0.04423552,0.032105643,-0.050860777,-0.004644647,0.08258467,0.03736196,0.10536799,0.047962207,-0.010589095,0.09865997,0.01599702,-0.053455245,-0.030611087,-0.026011642,0.004745023,0.003155341,0.09960472,0.05622145,-0.04153371,-0.068532,0.048093777,-0.051867872,-0.00979224,-0.04593618,-0.10011387,-0.015037222,0.06298729,0.033306196,0.023163097,0.099989474,0.08439122,-0.019487357,0.010384453,0.05467697,0.11554119,0.03305231,0.0060979202,-0.096314445,-0.03652518,-0.019780006,-0.017438639,-0.029233316,0.0009111724,-0.004473305,-0.028391752,-0.05258736,-0.013065436,-0.024045438,-0.08771253,-0.03046274,0.04278231,0.052054048,-4.070192e-33,0.06686733,-0.08792255,0.015616353,-0.07821299,-0.02263717,0.060806926,0.029849026,0.011904343,0.013854873,-0.009454719,0.04446661,-0.008707023,0.025952097,-0.03870319,0.03964685,0.0019977875,0.027897058,0.031787608,-0.039659973,-0.011331948,0.05514205,0.11274294,0.020699602,-0.0037182593,0.07295824,0.023516353,0.032118194,0.056044083,0.03338109,0.09142456,0.003732703,-0.0025506525,-0.036392905,-0.024084724,-0.011496363,0.106880024,-0.054190002,0.005595183,-0.08826906,0.019038482,-0.029653968,0.050916877,-0.0021364,0.14212383,-0.0012192549,0.06474338,-0.018739177,0.03248399,0.01746167,-0.12368856,0.04721257,0.050501786,0.0066862456,0.01232592,0.017347015,0.03233311,0.026329294,-0.011955113,-0.036512952,-0.07128899,-0.050510608,-0.026714271,0.053285275,-0.012473947,0.0059261415,0.011299311,0.06147528,0.011189027,-0.0044537974,0.03860352,0.01344967,0.03573569,-0.0147170015,0.07523745,-0.063878536,-0.001628537,-0.099816985,0.0032150648,0.009871642,-0.022914087,-0.010062309,-0.0422436,-0.046285614,-0.064159125,-0.03245328,-0.08461131,0.034175806,0.092003845,0.0027031458,-0.0121563785,-0.058741275,-0.02653752,-0.11874927,0.06444662,0.05183011,-3.8002582e-08,0.03959511,-0.06494674,0.008321322,-0.07295158,0.047134206,0.06850216,0.008338079,0.026321389,0.034387752,-0.023601146,7.116686e-05,0.09055007,-0.018166881,0.07536571,-0.028404705,-0.00027985012,-0.010141488,0.019700835,0.008510089,-0.05950922,-0.047400795,-0.013953812,-0.038478486,-0.014998426,-0.02676942,-0.012865237,0.066807844,0.025190432,0.008663522,-0.03823117,0.086126655,0.001247427,-0.04457099,-0.021082059,-0.1356685,0.034674477,0.012518788,0.015349212,-0.015675299,0.0764743,-0.06946593,-0.09461144,-0.070167504,0.06090726,-0.049166687,0.02079156,-0.034644622,-0.034068253,-0.016538447,-0.0045536524,0.030493995,-0.02350392,-0.057016317,-0.05514177,-0.13595109,0.024194581,-0.021408774,-0.0706603,0.013860699,-0.053230584,-0.013199973,0.057231117,0.114657775,-0.018319862 +5.4.3.4,Requires a cobamide coenzyme.,384,1.0,-0.021039283,-0.045378994,-0.06374199,-0.030825563,-0.05316796,-0.044055663,-0.050479542,0.065504834,-0.03201017,-0.0102919815,0.059763655,-0.0924502,-0.05151938,0.07253646,0.004442112,-0.029995328,0.06569627,0.0029298132,0.016946986,0.029199047,0.03231424,0.015316649,0.031249577,0.047321197,-0.061115235,0.045075845,0.06307106,0.008114093,0.061039645,-0.035059553,0.04419976,0.034279913,-0.018599398,-0.072547816,0.048908047,0.022017403,-0.04070863,-0.014472463,0.048870057,0.030235931,0.04387676,0.014694346,0.033546805,0.048378646,0.014555205,-0.030021915,0.018621957,0.009253188,0.032698616,0.00816518,-0.05901643,-0.05721429,-0.037078828,0.0059136455,-0.03997363,0.0003551846,-0.07198279,-0.0026689891,0.03803555,-0.0144533105,-0.022706805,-0.0031988388,-0.0021415101,0.04747235,0.047927704,0.041484274,0.031191926,-0.02691802,0.020550238,0.10229294,0.00020166881,-0.07380074,-0.00046142185,0.0530542,-0.043448687,-0.0019233784,-0.009203525,-0.09311735,0.104088485,0.07069256,-0.084184505,-0.053505745,0.026692541,0.058348596,0.116136216,0.019033145,0.030101608,-0.02762657,0.0069920206,-0.029402968,-0.0014328983,0.0057882494,0.024642823,-0.00081893033,-0.10550726,-0.0014681837,0.006111442,0.032950185,-0.048870377,-0.011019211,-0.024605216,0.054226745,-0.013742456,0.06786385,-0.07243311,-0.027537573,0.06101068,0.02720318,0.024675978,0.024976311,-0.057555337,0.044152524,0.08797646,-0.023181088,-0.02213261,0.062164966,0.08259532,-0.00842692,0.016858337,0.032214835,0.039643206,-0.02807893,-0.009471797,-0.005181311,0.0054903766,-0.022359056,0.01886665,2.6669825e-34,0.056953024,0.06398639,0.05796846,0.101271994,-0.0481561,0.03922652,-0.10446753,-0.04140088,-0.08210164,-0.053485356,-0.022543183,-0.06943483,0.00830025,0.049847778,-0.02843575,-0.023960125,-0.011769968,-0.012043874,0.08092382,0.007847428,0.020138761,0.0025645068,0.0024698232,0.06596867,-0.019298468,0.011356524,0.034986064,0.04420638,0.044120003,0.011980819,0.031976026,0.022349756,-0.03066533,-0.024664467,-0.0254832,0.10722654,-0.1300953,-0.022061843,-0.0065627014,0.07843815,0.0111493785,0.024680294,-0.011269778,-0.0090553975,0.13336234,-0.08402833,-0.0120674865,0.088741176,0.0061738514,0.030948792,0.011912795,-0.004101508,0.00390754,0.0050689066,-0.004597567,0.008770944,-0.009554137,-0.020198606,0.022929585,0.028430149,-0.026723422,0.026001845,-0.07213394,0.099466935,-0.049010057,0.029924441,-0.07706395,-0.031106872,-0.044922177,-0.03164149,-0.052702013,-0.066332,0.009526985,0.040930197,-0.0097329095,-0.022898443,-0.021507844,-0.05498282,0.06411439,-0.09191564,0.022795763,-0.093797736,0.040127102,0.055451114,0.010378019,-0.074264675,-0.047700424,0.010530212,-0.0057644933,0.018501814,0.08973367,-0.1080974,0.021826105,0.0019620415,0.019881565,1.2739731e-34,0.0048750537,-0.0822691,0.034232832,-0.020397311,0.012869564,0.045227442,0.084444284,-0.14379072,0.05118582,-0.067754485,0.093994156,-0.021949302,-0.011154397,-0.019688608,-0.024052843,0.07159504,0.017656635,0.030054376,0.015119015,-0.07261027,0.017832221,0.038751576,0.024524806,-0.0051029986,0.016733097,0.08873369,-0.0056397724,0.019359186,0.018024575,0.04756949,-0.04884234,-0.028655862,-0.0847393,-0.069440275,-0.04808739,0.03310553,-0.012998446,-0.0063146297,-0.054270573,-0.11066745,-0.05698678,0.013762021,-0.02832732,0.08383217,0.04777907,0.0064477012,0.020732902,-0.13079436,0.050475184,0.059664596,-0.033238262,-0.04539283,-0.07785597,-0.027541583,-0.013457132,0.017700318,0.01032847,-0.02054768,0.046505798,-0.010845552,0.0231469,0.053747192,0.0094698435,-0.024885003,0.059334826,-0.0030266661,-0.01117982,0.07853333,0.08850589,0.022147585,0.065021455,0.10675008,0.055654973,-0.039358124,0.009240379,-0.00857779,-0.06999115,-0.0009818797,-0.033350997,-0.041146968,-0.06523708,-0.0556326,0.04468873,0.01571054,-0.010062379,-0.11137246,0.014925822,-0.111695625,-0.032164622,0.06419921,-0.040423397,-0.0061733346,0.041507233,0.06973637,0.07221651,-1.7296799e-08,0.00691945,-0.017665615,0.0075400984,-0.106049165,0.050687637,0.07464192,0.03456367,-0.09765549,0.03296822,-0.0074045784,-0.0043066926,0.08718298,0.0957249,0.12114044,0.025846316,-0.023461498,-0.015422125,-0.04300826,-0.06949045,-0.09213839,-0.16802295,-0.0019810454,0.0057457113,0.037628215,-0.018647557,-0.021821361,0.057116143,0.107447796,-0.022321671,0.011256138,-0.025433175,-0.0014311576,0.036059212,-0.021465812,-0.08616858,0.03770672,0.042409558,0.04746311,-0.036828164,-0.014661403,-0.048560586,0.053786952,-0.07472713,0.058607344,0.15683405,-0.04710784,-0.020228194,0.0257327,-0.023182306,0.0052637365,0.04652157,-0.00408724,-0.037015755,0.018788327,-0.003880409,-0.01013921,-0.04165151,-0.0015265319,-0.004413742,-0.06846883,0.0060351733,-0.06279197,0.13497177,-0.08495967 +5.4.3.5,A pyridoxal-phosphate protein that requires a cobamide cofactor for activity.,384,1.0,0.012125464,-0.09799341,-0.09470462,-0.11905487,-0.01291361,0.034637686,0.026679493,0.0118302675,0.03617501,0.058412936,0.065628715,-0.024600537,-0.06255163,0.07462957,0.008592983,0.0064776842,0.003344781,-0.009117145,0.06987328,-0.05372379,0.06379375,0.059745133,0.017147938,0.029348237,-0.08314324,0.095176265,0.04642057,0.03979782,0.0058585857,-0.03983476,0.024330478,0.046318468,-0.03153725,-0.07139236,0.019046765,0.091749035,-0.09973985,-0.014301821,0.04622562,0.043641873,0.075954646,-0.020471828,0.0054401127,0.02002348,-0.055279206,-0.01674063,0.05206,0.009931467,0.06863324,-0.0018230538,-0.087344155,-0.027329067,-0.01767125,-0.026206447,-0.012569496,0.0634182,-0.026229255,0.03112241,0.028210027,-0.035873692,-0.01954711,-0.02636434,0.07914655,0.04090929,0.046511803,0.007915433,-0.009818662,-0.06198328,-0.044635676,0.039769303,-0.03353087,-0.031098949,0.09772956,-0.0247442,-0.0711109,0.068495736,-0.06812261,-0.04094462,0.010438273,0.010719459,0.0013797339,0.030159665,0.051394254,0.082195625,0.07122788,0.028858174,0.036839195,-0.014835534,0.010864281,-0.05083165,-0.0027766055,0.00045408486,0.081475526,0.024455551,-0.063527845,0.007837509,-0.001969889,0.0396784,-0.06879713,-0.08686782,-0.01239708,0.03688466,-0.0036913967,0.023940807,-0.08159258,-0.025661966,0.013809077,0.0633963,0.0378263,0.049725953,-0.10140479,0.04479934,0.0008181531,-0.042922664,0.011384712,0.032666605,0.07912458,0.017658949,-0.015365234,0.026594093,0.059275556,-0.077214316,0.005324148,0.0011532485,-0.034515273,-0.006530829,-0.07125397,-5.6379065e-34,0.096812494,0.081153214,0.057736702,0.044520054,-0.037523694,-0.05486847,-0.079705425,-0.07531586,-0.025813123,-0.06883259,0.010286235,0.021382716,0.06382438,0.04957121,-0.08690301,-0.02264374,-0.09564117,0.019097146,0.12267917,-0.04969923,0.064744845,0.10307467,0.022491777,0.118668884,-0.010667084,0.06402472,-0.018949535,0.014649674,-0.039719425,-0.0052020503,-0.0003625924,-0.061399247,-0.084505565,-0.034715094,0.06259269,-0.051448796,-0.077364035,-0.06724942,-0.02000475,-0.014297426,-0.037778907,-0.059732653,-0.0024123983,-0.024414323,0.045546066,-0.11469607,-0.036223855,0.052735746,-0.062924914,0.040372223,0.04638759,-0.04905142,0.056194123,0.016308103,-0.114266716,-0.020233646,-0.068155736,-0.024056723,0.040177666,0.05061943,0.0391282,-0.0052408804,-0.050894126,0.045349363,-0.024213288,-0.02485995,0.0030491592,-0.06474597,0.03808394,0.049909562,0.04893213,-0.04982613,0.046086542,0.05745565,0.014410508,0.0040703607,-0.02738295,-0.009580856,-0.041422848,0.049449246,0.035333034,-0.11546371,-0.0042264736,-0.029306969,-0.003582929,-0.03836132,-0.021080257,-0.034007113,-0.028977439,-0.01824529,0.047733903,-0.09285826,0.0020629195,0.057553332,-0.024053944,-4.4160995e-34,0.06324549,-0.06383667,0.115446396,-0.03246046,-0.05105057,0.02120167,0.12567538,-0.094697446,0.06263155,-0.026801752,0.011093291,0.008300915,-0.011796685,-0.063938245,-0.019787349,0.05701163,-0.026895024,0.019895937,0.027906956,-0.011581751,0.020339325,0.008937061,-0.011569335,0.030857844,0.044790067,0.12539522,0.024914023,-0.014434362,-0.035059657,0.017999329,-0.009839655,0.03271402,-0.034636155,-0.10776919,-0.09460425,-0.000108621185,-0.08810213,-0.012421973,-0.030968104,-0.10107572,-0.006268302,0.052177757,0.06825241,0.005064169,0.009183248,-0.007481593,-0.0032709658,-0.023408059,-0.017058661,0.026828254,-0.034568664,0.05813729,-0.065962695,-0.05293421,0.045935653,0.05962472,-0.0044688215,-0.010182507,0.03321552,0.015965404,0.011650127,0.014124701,0.0028687892,0.09828911,0.024190728,0.07960039,0.03662647,0.014111639,0.06390822,0.07925651,0.019023621,0.081319205,0.048461914,0.049787343,-0.052675817,0.030253239,-0.0763909,0.037833743,0.0043155425,0.026056997,-0.057961345,-0.055292718,-0.003939506,-0.050299607,0.011049914,-0.031069169,0.015491624,-0.007522797,0.008293857,0.011369038,-0.0046788976,-0.048455443,0.036735732,0.067052,0.053041108,-2.4098371e-08,0.06620247,0.0027123436,0.047454022,-0.114486635,0.03299693,0.036500122,0.014154156,-0.04401663,0.08445815,-0.019426089,0.041674357,-0.016899716,0.09167651,0.055602018,0.028373972,0.053419974,-0.010462682,-0.040595494,-0.01432166,-0.1117685,-0.06451215,-0.016977323,-0.052396554,0.072790295,0.036349326,-0.014218385,-0.008845093,0.06511422,-0.03190309,0.007527925,-0.00861894,-0.021391336,0.033513695,-0.08482618,-0.027686048,0.07336601,0.013020616,-0.014119732,-0.07105054,0.013590311,-0.08776768,0.0017224379,-0.018948324,-0.0071302056,0.028974382,0.070562854,-0.049723927,0.019730119,-0.06264828,-0.034623884,0.034245633,-0.0033826623,-0.10459208,-0.047851373,-0.11563684,0.03806955,0.008447512,-0.03951307,0.0055624517,-0.11979434,-0.020152831,-0.0429774,0.07681134,-0.068260655 +5.4.3.6,Requires ATP.,384,0.99999994,-0.028612431,0.039120086,0.01628997,0.0038213448,-0.05259959,-0.042727824,0.04305336,-0.0034477788,0.038832348,0.019429062,-0.011332476,-0.005994085,-0.077571616,0.09656996,0.021173457,-0.04091025,0.021105843,0.06632819,0.0028716691,-0.015870295,0.0815053,0.040351726,0.027118582,0.0011912035,-0.06432566,0.017575901,-0.028921656,0.0068365117,-0.015588346,-0.028354637,-0.06924677,-0.02444685,-0.02599995,-0.047772717,-0.04418624,0.10319454,-0.07757831,0.024901658,0.030586526,0.019437324,0.05679453,-0.09269998,-0.015495228,0.086495034,-0.020719327,-0.021069001,0.03341301,0.029388577,0.059313662,-0.044761132,-0.07072043,-0.016359143,0.010721083,0.0045024953,0.024643684,-0.014926887,-0.050062824,0.010357791,-0.04508075,-0.013877243,-0.027144069,0.0078860875,-0.06186595,0.069542006,0.07495507,-0.048149828,-0.01707243,0.039872073,0.047140412,0.03845552,-0.015932748,-0.011370204,-0.03448544,0.045860294,-0.01921173,0.013507585,-0.017239343,-0.058454428,0.118324906,0.015628915,-0.016045876,-0.0026576715,0.030518832,0.0494484,0.078136854,0.012152135,0.021981046,-0.020957852,-0.10731429,0.044383425,0.016743613,-0.002067589,0.02453189,-0.0014789024,0.0014962031,0.022388766,0.003154827,-0.035081606,-0.098037034,0.069299884,0.022504473,0.06983226,0.030535325,0.046787757,0.003601982,0.013660135,-0.020599611,-0.016153973,0.03298988,0.053445105,0.02408416,0.0010939375,0.02091759,0.009590293,-0.0324832,0.08236387,-0.00059221906,-0.039063573,-0.019270988,0.015675751,-0.100326195,-0.10023353,-0.019204259,-0.013345004,-0.043107394,-0.007384373,0.052917503,-5.369479e-33,0.016026147,-0.0494656,0.06813695,0.03763489,-0.04596337,0.004266927,-0.06601087,-0.0730049,-0.0054667816,-0.13009812,-0.020978196,-0.08933358,0.0058386754,0.0027628096,0.02559314,-0.039961785,-0.036862414,0.06410581,0.119147986,-0.044662658,0.007007945,-0.025933674,0.016778117,-0.07449644,-0.0046139313,0.024470206,-0.007601348,-0.06392706,0.01789388,0.0033969546,0.00026802692,-0.04643677,-0.051142868,-0.0026565837,-0.016493147,0.026462272,-0.05692362,-0.030454177,0.028562572,-0.029199084,-0.026921067,0.040373303,-0.010046751,-0.019160992,0.049423497,-0.052083608,-0.013371202,0.0675161,-0.04853487,0.061211646,0.114938825,-0.05503339,0.07050976,-0.01760474,-0.0031631803,-0.010899386,0.034552615,0.0031029687,0.00905185,0.096651495,0.03825509,0.066621125,-0.05657757,0.11790865,0.033146136,0.049333647,-0.10390855,-0.042500768,-0.037321363,0.06400072,-0.07994287,-0.061770067,0.038681343,-0.035981815,-0.0026599902,0.020435968,0.022433074,0.010995147,-0.056608927,0.039969243,0.03457246,-0.09892194,0.02464029,0.0419554,-0.033000685,-0.0012415753,-0.011238836,-0.0032867182,0.0800876,-0.0054475227,0.09281026,-0.07952532,-0.060136877,0.0527935,0.008453257,3.8771863e-33,0.05262237,-0.060271926,0.093226805,-0.0391868,0.048883855,0.040124808,0.0043365564,-0.13073942,-0.023709249,-0.021605302,-0.012559491,-0.0362165,-0.07148659,-0.02075307,-0.0046387864,0.0019677093,-0.028663317,0.04047669,-0.020127708,0.016713189,0.00058072014,0.12642317,0.06638313,0.043563433,-0.0022838921,0.030729389,-0.045455083,0.032519385,-0.00929451,0.011465864,0.028494375,-0.024362022,-0.097314954,-0.023265889,-0.051334143,0.03388213,-0.0010151012,0.09469274,-0.01633542,0.026696028,0.0582335,0.07990839,0.008013972,0.095891975,0.041471254,0.04629757,0.0568167,-0.010212162,-0.030543432,-0.0036702354,0.007310286,-0.017965417,-0.07712123,-0.0025109886,0.052209076,0.0025752552,-0.004223106,-0.011745519,0.016406145,-0.055485375,-0.032229785,-0.031125143,0.0039753504,-0.04941367,0.016220221,0.0070322813,-0.07312025,0.027422369,-0.035920642,0.052288137,0.041684493,0.09588136,0.014146875,-0.06271398,0.0031881472,0.11708409,-0.020003498,0.0118696885,-0.024113698,-0.036709808,-0.13065079,0.0524505,-0.086282685,-0.056882493,0.057199717,-0.0683492,0.035644997,-0.11089497,-0.007016321,0.032346588,0.025968099,-0.05098004,-0.0037162104,0.061554424,0.034611136,-1.165588e-08,0.01769645,0.013854357,0.077655055,-0.0309877,0.027003923,0.077035114,0.08668672,0.029999051,0.119653665,0.010411289,0.04535734,0.08159399,0.13845007,0.05255858,0.07445208,0.023057502,-0.0648906,0.05726715,-0.08667324,-0.0675176,-0.10053206,-0.100150675,-0.05714585,0.1656881,0.0473876,-0.08391541,0.06682429,0.037454676,0.025450025,-0.025492493,0.0480688,-0.037146427,0.014827325,0.020333612,-0.03949552,0.015315933,-0.0064771743,0.01280437,-0.05366662,-0.04600818,-0.12780747,0.026648631,-0.05717927,0.052171413,0.025576226,0.006272395,-0.07435277,0.048054658,-0.03407684,-0.033548974,0.011585943,-0.033534724,0.028340288,-0.05078219,-0.04682264,0.042157013,-0.021491332,-0.027723607,-0.011114431,-0.049072303,0.07333798,0.0070389197,0.15672521,-0.021551186 +5.4.3.7,Requires a cobamide cofactor.,384,0.99999994,0.011432075,-0.0491942,-0.1009864,-0.05413757,-0.056830667,-0.028730573,-0.022711942,0.049106624,-0.028359847,-0.028269192,0.089681625,-0.09792494,-0.06228527,0.06477275,-0.00057132996,-0.034916278,0.05937269,-0.0047276393,0.049365528,0.02818715,0.0067587732,0.015967777,0.008658403,0.012431679,-0.079679176,0.062112883,0.02587048,-0.00711991,0.062867425,-0.05576699,0.08051084,0.06424417,-0.06626834,-0.08931546,0.02736577,0.021811685,-0.044278823,-0.011512087,0.052436117,0.04009061,0.07000829,0.018660696,0.03161872,0.04003962,0.02063673,-0.029022941,0.04672963,0.016819566,0.059316028,-0.010560139,-0.066648394,-0.026730262,-0.017372984,-0.0050231065,-0.07845635,-0.0025118806,-0.056447785,-0.022638207,0.060459558,-0.004668812,-0.056933936,-0.0043723453,0.013630976,0.048158936,0.05991303,0.02376105,0.022940585,-0.089624956,-0.017699616,0.10641727,-0.009499878,-0.0536063,0.03090751,0.054492414,-0.031326286,0.030834967,-0.027527105,-0.07180264,0.12680711,0.018483596,-0.07313142,-0.015148858,0.0339475,0.053226925,0.10070623,0.0464856,0.041002486,-0.03649104,-0.018625874,-0.035754565,0.030455831,-0.011800866,0.060980376,0.005973152,-0.0585552,-0.019523427,0.024439724,0.060661845,-0.07466047,-0.016805861,-0.035312492,0.0021771966,-0.07450162,0.093983546,-0.12019609,-0.03529411,0.06331624,0.04430962,0.027972832,0.023143334,-0.067226425,0.042145513,0.0575232,-0.065911666,-0.01505019,0.05127543,0.07326842,-0.024998695,0.016596772,-0.03714194,0.032055132,-0.06199405,-0.0074718464,-0.020464523,0.01135233,-0.033816114,0.012399091,-3.6406329e-35,0.08710017,0.07195188,0.06279874,0.06360657,-0.053520035,0.02830947,-0.08992313,-0.061339848,-0.025678212,-0.07059124,0.00043297908,-0.01511844,-0.02588098,0.02499039,-0.035813894,-0.013384582,-0.022904335,-0.00208341,0.05462492,-0.029098703,0.024086574,0.035517965,-0.015462256,0.08085076,-0.014999307,0.057710044,0.041928485,0.036988795,-0.014397187,0.031299725,0.023568936,0.018150497,-0.025898797,0.008992647,-0.006635529,0.0888197,-0.12236708,-0.019530652,-0.006136441,0.009485504,-0.0017872258,0.030135153,0.008932185,-0.025277682,0.10865641,-0.08749338,-0.020098358,0.064708106,-0.017494978,0.044099182,0.00049068034,0.015474438,0.021682339,0.03858846,-0.005099398,0.016249705,-0.009263339,-0.010415693,0.06313147,0.033162296,-0.05505398,0.05695896,-0.03214734,0.08122639,-0.0396475,0.0339511,-0.065334454,-0.04883575,-0.016671086,-0.01880031,-0.050679795,-0.043328788,0.026527472,0.052278847,-0.005205164,-0.00082134316,-0.026675448,-0.04122416,-0.00070099183,-0.07958073,0.018568436,-0.1174832,0.041367024,0.018895688,0.035307955,-0.06889345,-0.074563004,0.014047569,-0.04675407,-0.02247306,0.075931326,-0.07694393,0.056592267,0.018622905,-0.024742909,-3.0976338e-34,-0.0047785,-0.076834954,0.057447124,-0.0057969014,-0.014474026,0.030772272,0.0945202,-0.14378883,0.052288745,-0.028331269,0.044354733,0.038584456,0.012538892,-0.03172735,-1.5328636e-05,0.05935679,0.017200835,-0.002139005,-0.0009321328,-0.058956876,0.019095773,0.039361775,0.027532905,0.021034632,0.0072659203,0.10040164,-0.009525995,0.0075747613,0.034451354,-0.0026984306,-0.036037236,-0.013357735,-0.09119725,-0.10997613,-0.07137618,-0.04155978,0.004990721,-0.016312368,-0.084673695,-0.11416893,-0.021455158,0.03192014,-0.004055424,0.06873264,0.027379876,-0.003932923,0.038886804,-0.087912194,0.04972663,0.08649469,-0.07793369,-0.038780093,-0.06379695,-0.045001365,0.0034848847,0.051831976,0.057951964,-0.02352264,0.01870731,0.024525061,0.0336345,0.04408862,0.002264462,-0.01929411,0.05458654,-0.012546877,0.004408355,0.09237885,0.10079628,0.029007599,0.071688324,0.11123632,0.044147313,-0.037082322,-0.01221554,0.0023528454,-0.063830376,1.673802e-05,0.0015362613,-0.017161772,-0.06615364,-0.06874318,0.03395075,0.004812233,0.03648512,-0.10323365,0.01878816,-0.100015536,-0.008090147,0.053209744,-0.036256045,-0.02722566,0.07696051,0.097078055,0.026715217,-1.741511e-08,-0.010199822,0.01861513,0.035917725,-0.08056874,0.025888583,0.05739062,0.025830803,-0.087280154,0.02316025,-0.04461164,0.053255923,0.06451939,0.06717605,0.13575932,0.029474813,-0.03062551,-0.035597406,-0.0482091,-0.07705939,-0.10077078,-0.13743322,-0.04989279,0.017520774,0.08046793,-0.00859756,-0.022249382,0.070680164,0.107999615,-0.015256744,0.05486184,-0.080060884,0.0019619109,0.04204455,-0.031282425,-0.05894243,0.032744445,0.039074477,0.03996152,-0.0059084296,-0.012840017,-0.052153334,0.07939738,-0.07015118,0.048632577,0.08869565,-0.011351803,-0.027252687,-0.008267795,-0.032294128,0.014521446,0.023376137,0.009664038,-0.04807141,0.022743119,-0.011551097,-0.015571258,-0.017558528,-0.022278218,0.016477384,-0.07322036,0.036243092,-0.04815458,0.12655243,-0.020703819 +5.4.3.8,Requires pyridoxal phosphate.,384,1.0,-0.01698044,-0.060914904,-0.026039632,-0.053427394,0.005568125,-0.07016387,0.014847883,0.019176481,0.0045266184,0.024525024,0.03317761,0.009873535,-0.07866256,0.10209709,-0.025082244,-0.0064309826,0.0067590442,0.005738732,0.03225184,-0.009795652,0.098599575,0.025559787,0.033756122,0.004641547,-0.028178824,0.07414114,0.012579007,0.051151235,0.030199911,-0.024904195,-0.009421179,0.04300537,-0.053982887,-0.12522857,0.03998752,0.08965899,-0.101827376,0.035652604,-0.0051363655,-0.0024491,0.078520484,-0.119811535,0.014415333,0.019671818,-0.042124342,-0.006552009,0.07138521,0.025010915,0.05655868,-0.031260718,-0.12182232,0.025150422,-0.012411364,-0.049636956,-0.04675769,-0.025666894,0.014200526,0.0423539,-0.025092019,-0.03355766,-0.038389243,-0.016393166,-0.037729964,0.016686326,0.05483597,0.00046699485,0.014817033,-0.067265764,-0.027321614,0.05524283,-0.021016654,0.009983545,0.038643163,0.01169927,-0.050602566,0.07519418,-0.003173716,-0.07402124,0.035113707,0.044252906,-0.032064255,-0.0070339874,-0.00048019888,0.08636919,0.11245382,0.08770617,0.010848838,-0.042085625,-0.10944375,-0.0081388205,0.0094010355,0.026456323,0.02542774,0.029123995,0.0144725805,0.019870229,-0.010289679,-0.011969612,-0.07218864,-0.00047550636,-0.057344228,0.030022722,-0.041202158,0.011980159,-0.06272461,-0.030854823,-0.036505237,-1.8021296e-05,-0.008034694,0.021144945,-0.038632177,0.05850506,-0.0014720595,0.038273867,-0.016046248,0.03991441,0.026020808,-0.027772814,-0.065175086,0.048679955,-0.015996248,-0.054232337,-0.043915447,0.044271927,-0.054382365,-0.07281729,0.020225057,1.5531386e-33,0.07431184,0.10313174,0.034787737,0.032895874,-0.04832213,0.06504399,-0.0957705,-0.10009979,-0.05120853,-0.03556984,-0.0045857425,-0.04371053,-0.0034642976,0.0020455492,-0.05519527,-0.062339973,-0.042718697,0.04879,0.096222565,-0.048971783,0.07830896,0.018590098,-0.032450855,0.084621586,-0.0515951,0.12010809,-0.01023605,-0.014285863,-0.004171265,0.007187098,0.060824182,-0.057582982,-0.04002258,-0.033592958,-0.021253698,-0.019236375,-0.08583155,-0.070074275,-0.027212925,0.002238871,-0.012635754,0.030807827,0.0040793167,0.046909947,0.06508118,-0.119482376,-0.010071649,0.09835046,-0.013476747,0.08049833,0.0066486686,-0.0115671605,0.056550972,-0.009165868,-0.059446983,-0.048001066,0.0043265494,-0.08918777,0.02850191,0.02511981,0.019057373,0.020133808,-0.028691925,0.04793161,0.028718073,-0.025368784,-0.0060321544,-0.021175377,0.025043491,0.038113125,0.018939601,-0.046697836,0.053076018,0.044318266,-0.044483967,-0.019166293,-0.0071860123,0.015270741,0.0056268494,-0.012539033,0.007703417,-0.104076244,-0.015290014,-0.004414741,-0.018390698,-0.023467334,-0.027887093,0.0124496855,0.020228941,0.013959066,0.07261838,-0.15188219,-0.027846562,-0.005903195,-0.027840946,-1.6352574e-33,0.058115195,-0.04225742,0.088828534,-0.0017226202,0.0011678691,-0.0024156682,0.078942746,-0.07130741,0.076272056,0.007272294,0.011563536,-0.02068374,0.013856999,-0.019587928,-0.012665377,0.053132538,0.022508586,0.024050489,0.0464914,0.010839173,-0.0007868879,0.09052416,0.007738702,0.1502203,0.04589288,0.0693116,-0.022613889,0.000107057414,-0.068264015,0.028982649,-0.007896613,0.018588644,-0.10559938,-0.07635186,-0.07456817,-0.020084996,-0.06383046,0.028129093,-0.035793763,-0.018401593,0.049199436,0.04063823,0.029846797,0.06454732,-0.061198603,0.029742729,0.057415262,-0.026129756,0.030671991,0.02532254,0.01609252,0.051802527,-0.06897964,-0.024146315,0.050703216,0.022799771,0.012979817,-0.00015278473,-0.014831243,-0.01728685,0.06722105,-0.018892212,-0.02129298,-0.009067866,0.020127648,0.061080374,0.045078497,0.07054896,0.07281674,0.05767188,0.057891056,0.10093886,0.117318526,0.0023699822,-0.0331875,0.020371107,-0.06727826,0.04940503,0.034535013,-0.05674581,-0.031519208,-0.035764553,-0.038033582,-0.063126795,0.07742833,-0.10121765,0.061402068,-0.042743035,-0.041932344,0.014276701,0.006949037,-0.023314904,0.058389265,0.08998426,0.06836844,-2.0110871e-08,0.034124844,-0.0006208569,0.052697644,-0.068447985,0.007815051,-0.011588709,0.11196444,0.010290502,0.040306922,-0.04938998,0.02008432,0.028162492,0.10765556,0.0511653,0.105984345,-0.0004609586,-0.008213988,0.029790655,-0.05944368,-0.11575656,-0.1263343,-0.038517773,-0.08786758,0.048166655,0.04522457,0.02689124,0.04905569,0.010422795,0.023364438,0.04964363,0.032405645,-0.055625685,-0.021115601,-0.067931764,-0.051147096,0.09063021,0.001539197,0.024773546,-0.042903315,-0.051487952,-0.107708976,0.009853652,-0.008999365,0.021058766,-0.004091304,0.028258841,-0.10901795,0.028752163,-0.04539198,0.006062855,0.058664586,-0.031561986,-0.03954017,-0.056832965,-0.079223104,0.05454516,0.04760045,-0.018326037,-0.0032895461,-0.09405242,0.04716298,-0.020520255,0.11330077,-0.08565016 +5.4.4.2,Requires Mg2+. The reaction is reversible.,384,0.99999994,-0.084705904,-0.0350064,0.0141957225,0.058857292,0.018328207,-0.07430707,-0.017481739,-0.012727486,-0.059734143,0.056549814,0.01881022,0.004756281,-0.008586669,0.022450054,-0.0036212464,-1.0820785e-05,0.039633628,0.069977514,0.038150676,0.041637752,0.056239612,-0.04407047,0.023161622,-0.028274955,0.017040512,0.1010572,0.047653727,0.027927937,0.049485825,-0.022894096,0.011538515,0.027688542,-0.0042893137,-0.09867002,-0.03633617,0.07389891,-0.06896736,0.005421048,-0.040486973,-0.021101039,0.014927598,-0.013539132,0.09452924,-0.07346363,0.07832143,-0.08471392,0.040039897,-0.046166826,0.07496032,0.05787092,0.02565151,0.021287493,-0.095504716,0.019987185,0.0042436766,0.0070701707,-0.09528583,0.0019429171,0.002728032,-0.021649068,-0.032495193,-0.028447708,-0.09134822,-0.011692751,0.061727006,0.035535,0.025767796,-0.10176757,0.045387793,0.021685867,0.026343515,-0.06123873,-0.022812773,-0.0643542,-0.0070817866,-0.015420577,0.054524668,-0.06286265,0.06947594,0.0934039,-0.04740115,-0.03955424,0.07230476,0.057013735,0.023242543,0.030628346,0.019573279,0.017660437,0.026399964,0.068350196,0.01558895,0.08612715,0.059758965,0.03473578,-0.00046470444,-0.008378998,-0.050493576,0.031594355,0.009782459,0.0148604,-0.035431545,0.046089012,-0.07014265,-0.004025687,-0.07863225,0.00014547727,-0.016470172,0.02919693,-0.045506094,0.05035397,0.051668655,0.0015500567,0.081427775,0.046281468,0.020094689,0.0500178,-0.031921975,-0.09314162,-0.06477261,-0.05115628,0.06081722,0.01623839,-0.056294836,-0.007874681,-0.06038441,-0.013097733,0.02568141,-2.2882603e-33,-0.037151765,0.02975638,0.059987668,0.0040630205,-0.05941605,0.075243965,-0.07070073,-0.04904906,-0.012485602,-0.032227907,-0.017482378,-0.031331327,-0.028640525,0.033340827,-0.043086436,-0.06959535,0.06518425,0.04468662,0.064245895,-0.062481936,0.0019154669,0.06494841,-0.055840526,-0.049759023,-0.033164658,0.12521486,0.043478906,-0.063538864,0.046400484,0.0022172714,0.0644792,-0.052364938,-0.050616704,0.04824918,-0.012311073,0.040438917,-0.047807664,-0.031483497,0.028891666,0.024293888,-0.07114011,0.042233005,-0.113359116,0.025151864,0.07066933,-0.10843368,0.066799775,0.029605715,-0.01942156,0.050703477,0.06456284,0.028325785,-0.04181753,0.046913896,-0.029083949,0.045994364,0.034458827,0.049806006,0.063225,0.01723235,0.00027491528,0.06117651,0.07365477,0.031461406,0.063233696,0.058631897,-0.08865535,-0.039762225,-0.044806805,-0.008822477,-0.0008411082,-0.029628066,0.082035445,0.022549266,-0.000530132,-0.032894634,0.017603034,0.019080529,0.05942994,0.016766857,-0.05100996,-0.045076616,-0.020473234,0.005268952,-0.055984084,-0.056248225,-0.046355776,-0.05291597,-0.00034862888,0.031536765,0.033891737,-0.050588988,-0.00268999,0.0334961,0.016302722,1.4798741e-33,0.010694157,-0.03601666,-0.008670368,0.014080445,-0.094589256,0.036728743,0.03599429,-0.12753898,0.04824879,0.036637153,0.04966793,0.0068443604,-0.028058112,-0.0551129,0.008505551,-0.010932027,0.010831707,0.058552004,-0.03199523,-0.035973486,0.017678084,0.13670075,0.06430836,0.059500962,0.064371094,0.027338577,0.05367684,0.0035495847,0.08797,0.07239089,0.018590098,0.031191409,-0.06931919,-0.04529363,-0.044671305,0.051437974,0.015664343,-0.003839191,-0.046867702,0.018935582,-0.0031799837,0.028199777,0.025517896,0.086204566,-0.0039175777,-0.0010798337,0.059467807,0.010515135,0.07013426,-0.046211872,-0.00054531737,-0.015725642,-0.06398672,-0.054370686,0.052706983,-0.002633466,0.049574587,-0.040896926,0.04790104,-0.04672112,0.04493158,-0.057745967,0.1049499,-0.13831778,0.029877705,0.064042754,-0.009377316,0.08285828,0.06456408,0.0061213477,0.11131214,0.111393854,0.11270283,-0.0415768,0.05646627,0.033620678,-0.02365001,-0.019529972,0.02867006,-0.11990283,-0.01877931,0.029371254,0.026677972,-0.057154797,0.0054034335,-0.1726043,-0.040173333,0.05817304,-0.013428165,0.016017549,-0.03790916,-0.06904044,0.05072543,0.050872866,0.03404714,-1.7999572e-08,-0.077546135,-0.025081314,0.08120812,-0.02928465,-0.041473784,0.11375383,-0.008451073,-0.06472302,-0.0040302803,-0.07042643,0.018682798,0.0052611907,0.030109385,0.025189904,0.0049117976,-0.005288706,-0.038290124,-0.0069148014,-0.06937807,-0.06959341,-0.07527228,-0.08266913,-0.06795904,0.017180983,-0.0050219726,-0.036840044,-0.012882373,0.04138657,-0.042210314,-0.038152818,0.011204033,-0.0327896,-0.037813418,-0.008951524,-0.0174386,0.0066226046,0.013682205,0.007053567,-0.009233034,-0.12898916,-0.08881804,0.013325888,0.017825441,0.046322744,-0.090891026,-0.006776606,0.027359538,-0.04455166,-0.0931185,0.042136483,0.07887389,-0.08185638,-0.016806269,-0.065838434,-0.0020924006,0.017296636,0.037696533,-0.014434075,-0.01072446,-0.0732338,0.042091653,0.0104755005,0.027396495,-0.030194022 +5.4.99.1,Requires a cobamide cofactor.,384,0.99999994,0.011432075,-0.0491942,-0.1009864,-0.05413757,-0.056830667,-0.028730573,-0.022711942,0.049106624,-0.028359847,-0.028269192,0.089681625,-0.09792494,-0.06228527,0.06477275,-0.00057132996,-0.034916278,0.05937269,-0.0047276393,0.049365528,0.02818715,0.0067587732,0.015967777,0.008658403,0.012431679,-0.079679176,0.062112883,0.02587048,-0.00711991,0.062867425,-0.05576699,0.08051084,0.06424417,-0.06626834,-0.08931546,0.02736577,0.021811685,-0.044278823,-0.011512087,0.052436117,0.04009061,0.07000829,0.018660696,0.03161872,0.04003962,0.02063673,-0.029022941,0.04672963,0.016819566,0.059316028,-0.010560139,-0.066648394,-0.026730262,-0.017372984,-0.0050231065,-0.07845635,-0.0025118806,-0.056447785,-0.022638207,0.060459558,-0.004668812,-0.056933936,-0.0043723453,0.013630976,0.048158936,0.05991303,0.02376105,0.022940585,-0.089624956,-0.017699616,0.10641727,-0.009499878,-0.0536063,0.03090751,0.054492414,-0.031326286,0.030834967,-0.027527105,-0.07180264,0.12680711,0.018483596,-0.07313142,-0.015148858,0.0339475,0.053226925,0.10070623,0.0464856,0.041002486,-0.03649104,-0.018625874,-0.035754565,0.030455831,-0.011800866,0.060980376,0.005973152,-0.0585552,-0.019523427,0.024439724,0.060661845,-0.07466047,-0.016805861,-0.035312492,0.0021771966,-0.07450162,0.093983546,-0.12019609,-0.03529411,0.06331624,0.04430962,0.027972832,0.023143334,-0.067226425,0.042145513,0.0575232,-0.065911666,-0.01505019,0.05127543,0.07326842,-0.024998695,0.016596772,-0.03714194,0.032055132,-0.06199405,-0.0074718464,-0.020464523,0.01135233,-0.033816114,0.012399091,-3.6406329e-35,0.08710017,0.07195188,0.06279874,0.06360657,-0.053520035,0.02830947,-0.08992313,-0.061339848,-0.025678212,-0.07059124,0.00043297908,-0.01511844,-0.02588098,0.02499039,-0.035813894,-0.013384582,-0.022904335,-0.00208341,0.05462492,-0.029098703,0.024086574,0.035517965,-0.015462256,0.08085076,-0.014999307,0.057710044,0.041928485,0.036988795,-0.014397187,0.031299725,0.023568936,0.018150497,-0.025898797,0.008992647,-0.006635529,0.0888197,-0.12236708,-0.019530652,-0.006136441,0.009485504,-0.0017872258,0.030135153,0.008932185,-0.025277682,0.10865641,-0.08749338,-0.020098358,0.064708106,-0.017494978,0.044099182,0.00049068034,0.015474438,0.021682339,0.03858846,-0.005099398,0.016249705,-0.009263339,-0.010415693,0.06313147,0.033162296,-0.05505398,0.05695896,-0.03214734,0.08122639,-0.0396475,0.0339511,-0.065334454,-0.04883575,-0.016671086,-0.01880031,-0.050679795,-0.043328788,0.026527472,0.052278847,-0.005205164,-0.00082134316,-0.026675448,-0.04122416,-0.00070099183,-0.07958073,0.018568436,-0.1174832,0.041367024,0.018895688,0.035307955,-0.06889345,-0.074563004,0.014047569,-0.04675407,-0.02247306,0.075931326,-0.07694393,0.056592267,0.018622905,-0.024742909,-3.0976338e-34,-0.0047785,-0.076834954,0.057447124,-0.0057969014,-0.014474026,0.030772272,0.0945202,-0.14378883,0.052288745,-0.028331269,0.044354733,0.038584456,0.012538892,-0.03172735,-1.5328636e-05,0.05935679,0.017200835,-0.002139005,-0.0009321328,-0.058956876,0.019095773,0.039361775,0.027532905,0.021034632,0.0072659203,0.10040164,-0.009525995,0.0075747613,0.034451354,-0.0026984306,-0.036037236,-0.013357735,-0.09119725,-0.10997613,-0.07137618,-0.04155978,0.004990721,-0.016312368,-0.084673695,-0.11416893,-0.021455158,0.03192014,-0.004055424,0.06873264,0.027379876,-0.003932923,0.038886804,-0.087912194,0.04972663,0.08649469,-0.07793369,-0.038780093,-0.06379695,-0.045001365,0.0034848847,0.051831976,0.057951964,-0.02352264,0.01870731,0.024525061,0.0336345,0.04408862,0.002264462,-0.01929411,0.05458654,-0.012546877,0.004408355,0.09237885,0.10079628,0.029007599,0.071688324,0.11123632,0.044147313,-0.037082322,-0.01221554,0.0023528454,-0.063830376,1.673802e-05,0.0015362613,-0.017161772,-0.06615364,-0.06874318,0.03395075,0.004812233,0.03648512,-0.10323365,0.01878816,-0.100015536,-0.008090147,0.053209744,-0.036256045,-0.02722566,0.07696051,0.097078055,0.026715217,-1.741511e-08,-0.010199822,0.01861513,0.035917725,-0.08056874,0.025888583,0.05739062,0.025830803,-0.087280154,0.02316025,-0.04461164,0.053255923,0.06451939,0.06717605,0.13575932,0.029474813,-0.03062551,-0.035597406,-0.0482091,-0.07705939,-0.10077078,-0.13743322,-0.04989279,0.017520774,0.08046793,-0.00859756,-0.022249382,0.070680164,0.107999615,-0.015256744,0.05486184,-0.080060884,0.0019619109,0.04204455,-0.031282425,-0.05894243,0.032744445,0.039074477,0.03996152,-0.0059084296,-0.012840017,-0.052153334,0.07939738,-0.07015118,0.048632577,0.08869565,-0.011351803,-0.027252687,-0.008267795,-0.032294128,0.014521446,0.023376137,0.009664038,-0.04807141,0.022743119,-0.011551097,-0.015571258,-0.017558528,-0.022278218,0.016477384,-0.07322036,0.036243092,-0.04815458,0.12655243,-0.020703819 +5.4.99.2,Requires a cobamide coenzyme.,384,1.0,-0.021039283,-0.045378994,-0.06374199,-0.030825563,-0.05316796,-0.044055663,-0.050479542,0.065504834,-0.03201017,-0.0102919815,0.059763655,-0.0924502,-0.05151938,0.07253646,0.004442112,-0.029995328,0.06569627,0.0029298132,0.016946986,0.029199047,0.03231424,0.015316649,0.031249577,0.047321197,-0.061115235,0.045075845,0.06307106,0.008114093,0.061039645,-0.035059553,0.04419976,0.034279913,-0.018599398,-0.072547816,0.048908047,0.022017403,-0.04070863,-0.014472463,0.048870057,0.030235931,0.04387676,0.014694346,0.033546805,0.048378646,0.014555205,-0.030021915,0.018621957,0.009253188,0.032698616,0.00816518,-0.05901643,-0.05721429,-0.037078828,0.0059136455,-0.03997363,0.0003551846,-0.07198279,-0.0026689891,0.03803555,-0.0144533105,-0.022706805,-0.0031988388,-0.0021415101,0.04747235,0.047927704,0.041484274,0.031191926,-0.02691802,0.020550238,0.10229294,0.00020166881,-0.07380074,-0.00046142185,0.0530542,-0.043448687,-0.0019233784,-0.009203525,-0.09311735,0.104088485,0.07069256,-0.084184505,-0.053505745,0.026692541,0.058348596,0.116136216,0.019033145,0.030101608,-0.02762657,0.0069920206,-0.029402968,-0.0014328983,0.0057882494,0.024642823,-0.00081893033,-0.10550726,-0.0014681837,0.006111442,0.032950185,-0.048870377,-0.011019211,-0.024605216,0.054226745,-0.013742456,0.06786385,-0.07243311,-0.027537573,0.06101068,0.02720318,0.024675978,0.024976311,-0.057555337,0.044152524,0.08797646,-0.023181088,-0.02213261,0.062164966,0.08259532,-0.00842692,0.016858337,0.032214835,0.039643206,-0.02807893,-0.009471797,-0.005181311,0.0054903766,-0.022359056,0.01886665,2.6669825e-34,0.056953024,0.06398639,0.05796846,0.101271994,-0.0481561,0.03922652,-0.10446753,-0.04140088,-0.08210164,-0.053485356,-0.022543183,-0.06943483,0.00830025,0.049847778,-0.02843575,-0.023960125,-0.011769968,-0.012043874,0.08092382,0.007847428,0.020138761,0.0025645068,0.0024698232,0.06596867,-0.019298468,0.011356524,0.034986064,0.04420638,0.044120003,0.011980819,0.031976026,0.022349756,-0.03066533,-0.024664467,-0.0254832,0.10722654,-0.1300953,-0.022061843,-0.0065627014,0.07843815,0.0111493785,0.024680294,-0.011269778,-0.0090553975,0.13336234,-0.08402833,-0.0120674865,0.088741176,0.0061738514,0.030948792,0.011912795,-0.004101508,0.00390754,0.0050689066,-0.004597567,0.008770944,-0.009554137,-0.020198606,0.022929585,0.028430149,-0.026723422,0.026001845,-0.07213394,0.099466935,-0.049010057,0.029924441,-0.07706395,-0.031106872,-0.044922177,-0.03164149,-0.052702013,-0.066332,0.009526985,0.040930197,-0.0097329095,-0.022898443,-0.021507844,-0.05498282,0.06411439,-0.09191564,0.022795763,-0.093797736,0.040127102,0.055451114,0.010378019,-0.074264675,-0.047700424,0.010530212,-0.0057644933,0.018501814,0.08973367,-0.1080974,0.021826105,0.0019620415,0.019881565,1.2739731e-34,0.0048750537,-0.0822691,0.034232832,-0.020397311,0.012869564,0.045227442,0.084444284,-0.14379072,0.05118582,-0.067754485,0.093994156,-0.021949302,-0.011154397,-0.019688608,-0.024052843,0.07159504,0.017656635,0.030054376,0.015119015,-0.07261027,0.017832221,0.038751576,0.024524806,-0.0051029986,0.016733097,0.08873369,-0.0056397724,0.019359186,0.018024575,0.04756949,-0.04884234,-0.028655862,-0.0847393,-0.069440275,-0.04808739,0.03310553,-0.012998446,-0.0063146297,-0.054270573,-0.11066745,-0.05698678,0.013762021,-0.02832732,0.08383217,0.04777907,0.0064477012,0.020732902,-0.13079436,0.050475184,0.059664596,-0.033238262,-0.04539283,-0.07785597,-0.027541583,-0.013457132,0.017700318,0.01032847,-0.02054768,0.046505798,-0.010845552,0.0231469,0.053747192,0.0094698435,-0.024885003,0.059334826,-0.0030266661,-0.01117982,0.07853333,0.08850589,0.022147585,0.065021455,0.10675008,0.055654973,-0.039358124,0.009240379,-0.00857779,-0.06999115,-0.0009818797,-0.033350997,-0.041146968,-0.06523708,-0.0556326,0.04468873,0.01571054,-0.010062379,-0.11137246,0.014925822,-0.111695625,-0.032164622,0.06419921,-0.040423397,-0.0061733346,0.041507233,0.06973637,0.07221651,-1.7296799e-08,0.00691945,-0.017665615,0.0075400984,-0.106049165,0.050687637,0.07464192,0.03456367,-0.09765549,0.03296822,-0.0074045784,-0.0043066926,0.08718298,0.0957249,0.12114044,0.025846316,-0.023461498,-0.015422125,-0.04300826,-0.06949045,-0.09213839,-0.16802295,-0.0019810454,0.0057457113,0.037628215,-0.018647557,-0.021821361,0.057116143,0.107447796,-0.022321671,0.011256138,-0.025433175,-0.0014311576,0.036059212,-0.021465812,-0.08616858,0.03770672,0.042409558,0.04746311,-0.036828164,-0.014661403,-0.048560586,0.053786952,-0.07472713,0.058607344,0.15683405,-0.04710784,-0.020228194,0.0257327,-0.023182306,0.0052637365,0.04652157,-0.00408724,-0.037015755,0.018788327,-0.003880409,-0.01013921,-0.04165151,-0.0015265319,-0.004413742,-0.06846883,0.0060351733,-0.06279197,0.13497177,-0.08495967 +5.4.99.3,Requires ascorbic acid; also converts 2-aceto-2-hydroxybutanoate to 3-hydroxy-3-methyl-2-oxopentanoate.,384,1.0,-0.034655005,-0.047777012,-0.094385475,0.033608284,0.027050883,0.018497042,-0.03018893,0.037924677,-0.014705792,-0.072615884,0.04871914,-0.13135402,-0.06966202,-0.0058944556,-0.02767115,0.053054284,0.005232672,0.05834751,-0.01662736,-0.015933787,0.07608336,0.026479503,0.0662768,-0.013712302,-0.0043721423,0.020066436,-0.037438694,-0.017724957,0.028538818,-0.11223812,0.010129376,0.002405721,0.0050740554,-0.083353505,0.0339848,0.077308975,-0.055401288,-0.027182797,0.061525162,0.06194615,0.04462283,-0.04212828,0.01567747,0.015740078,0.0006239217,-0.07051675,0.027536089,-0.0026052126,0.059168972,-0.0016834983,-0.06567966,0.0294515,-0.114693105,-0.037371967,-0.028573632,0.014433919,0.028969726,0.022804571,-0.037671957,0.067323014,0.0033768625,0.032044943,-0.019767126,-0.007395999,-0.025489619,-0.070856035,-0.019525595,-0.02219419,-0.021176733,0.030061737,-0.073015116,-0.045163557,0.0005366114,0.06933078,0.026215894,0.007874757,-0.061397623,-0.04108488,0.091206916,-0.019263105,0.045428976,-0.01778331,-0.0665974,0.06670343,0.06050555,0.007579819,-0.04908583,-0.028660558,-0.014917339,0.081643425,-0.04590099,0.0076862285,-0.020050837,0.005062803,-0.013081533,-0.021479705,0.09252908,0.06669663,0.015730774,0.019361414,0.00059809186,0.07471864,0.0262038,-0.08190833,-0.023488466,-0.047901634,0.023311257,0.0252408,0.044733796,0.024703735,-0.023193182,-0.06607352,-0.023024,-0.07061431,-0.023685964,0.16679722,-0.045637798,-0.118650265,-0.037720915,-0.028200947,0.0074996445,-0.0040337318,0.015072624,0.02752361,-0.07491408,-0.017656477,0.023490978,2.7099505e-33,-0.0008549355,0.07883999,-0.01330404,0.023229016,-0.035808362,0.0075531085,-0.1383965,-0.040977497,0.039936088,-0.011849614,-0.012235331,-0.026487853,0.007019542,0.10484073,-0.011297835,-0.07242494,-0.050106406,-0.010958757,0.02023088,-0.008005095,0.046791717,0.030965406,-0.07836316,0.04211995,-0.054074667,-0.031944346,0.07976875,0.025924394,0.0610019,-0.0043897824,0.051527638,-0.015950786,-0.048082337,-0.051094495,-0.014997415,-0.014608888,-0.02943518,-0.066478774,0.026116842,0.03601736,0.05018615,0.097882584,0.005222985,-0.0029449959,0.06159999,-0.0395747,-0.010648389,0.15653384,0.06230735,0.013011956,0.022345295,-0.013475716,0.057899855,0.05183822,-0.03842644,-0.0256714,-0.03593627,0.008873568,0.045582525,-0.017578453,-0.0002741412,0.023818903,-0.008669707,-0.002632824,-0.07540977,0.038237263,-0.026401594,-0.00997087,-0.009959521,-0.058597766,-0.027060984,-0.038324203,0.008024681,0.06111811,-0.032807965,0.000684389,-0.042989306,0.023261707,0.06794406,-0.084085606,0.010362157,0.020260992,0.040914457,0.021566316,-0.066507176,0.0055259485,0.015754187,0.0016229515,-0.0016140182,0.066443324,0.058620058,-0.04277999,-0.053550832,-0.020276539,0.05823065,-3.5474072e-33,0.023922091,-0.005811442,-0.0149158025,-0.049955007,0.0030461098,0.03698533,0.07656763,-0.073286034,0.02111287,-0.03138435,0.03136151,0.03058675,0.0202977,-0.07403018,0.051724333,-0.058697484,-0.037603702,0.11728423,-0.025218083,0.06854247,0.08670587,0.044618182,-0.011483459,0.13225217,0.061621338,0.064800166,-0.0040365905,-0.049827956,0.031581372,0.10483102,0.0071014315,-0.029541112,-0.037125833,-0.030485457,-0.07124871,0.048264116,0.010084004,-0.011304279,-0.14435685,0.005197913,-0.017650466,-0.003973219,-0.02057025,0.08119552,0.019084772,0.101230785,-0.016886884,-0.017576324,0.012270302,-0.031864043,0.0099267345,-0.0387723,-0.09401493,-0.03783229,0.029739931,0.043722186,-0.004767436,-0.072707474,0.011616691,-0.07405355,-0.06246779,-0.013697886,0.044109765,-0.15458587,0.017593741,0.013746422,0.03585121,0.061046507,-0.012372068,-0.0078048026,0.067015626,0.08104308,0.10129258,-0.01167477,0.0057984143,-0.063561216,-0.07898696,-0.014457815,-0.069273695,-0.059151646,-0.021533752,-0.0368614,0.040048294,-0.016887061,-0.010507718,-0.09387408,0.0063881977,0.022767916,-0.064455196,0.09296596,-0.034185674,-0.0029943963,-0.079808496,0.09762007,0.035778962,-3.7733695e-08,-0.020457484,-0.00412884,0.109888025,-0.014287299,-0.049300887,0.03732057,0.030846488,0.016384527,0.058429476,-0.10318835,-0.034673247,0.096192494,0.0661331,0.064937465,-0.005525616,-0.010122105,-0.015918056,0.11133466,-0.005037212,-0.059979443,-0.110360816,-0.036630075,-0.02842373,0.011547408,0.030824924,-0.029802065,-0.0026651567,0.0870967,0.07910777,-0.022008466,0.06442007,0.028861113,0.023333114,-0.06921778,-0.045555197,0.035067696,-0.0017204689,-0.004517592,0.0035865644,-0.027925001,-0.03797556,0.018110314,-0.07539143,0.058645386,0.058215067,-0.043233775,-0.05275409,0.073468156,-0.02883328,-0.00050603243,0.036939934,-0.047812518,-0.027259326,-0.03602199,-0.028082205,0.010928405,-0.0406621,-0.00054422335,0.0024220136,-0.04445583,0.008700952,0.03404809,0.18119241,0.008808837 +5.4.99.4,Requires a cobamide cofactor.,384,0.99999994,0.011432075,-0.0491942,-0.1009864,-0.05413757,-0.056830667,-0.028730573,-0.022711942,0.049106624,-0.028359847,-0.028269192,0.089681625,-0.09792494,-0.06228527,0.06477275,-0.00057132996,-0.034916278,0.05937269,-0.0047276393,0.049365528,0.02818715,0.0067587732,0.015967777,0.008658403,0.012431679,-0.079679176,0.062112883,0.02587048,-0.00711991,0.062867425,-0.05576699,0.08051084,0.06424417,-0.06626834,-0.08931546,0.02736577,0.021811685,-0.044278823,-0.011512087,0.052436117,0.04009061,0.07000829,0.018660696,0.03161872,0.04003962,0.02063673,-0.029022941,0.04672963,0.016819566,0.059316028,-0.010560139,-0.066648394,-0.026730262,-0.017372984,-0.0050231065,-0.07845635,-0.0025118806,-0.056447785,-0.022638207,0.060459558,-0.004668812,-0.056933936,-0.0043723453,0.013630976,0.048158936,0.05991303,0.02376105,0.022940585,-0.089624956,-0.017699616,0.10641727,-0.009499878,-0.0536063,0.03090751,0.054492414,-0.031326286,0.030834967,-0.027527105,-0.07180264,0.12680711,0.018483596,-0.07313142,-0.015148858,0.0339475,0.053226925,0.10070623,0.0464856,0.041002486,-0.03649104,-0.018625874,-0.035754565,0.030455831,-0.011800866,0.060980376,0.005973152,-0.0585552,-0.019523427,0.024439724,0.060661845,-0.07466047,-0.016805861,-0.035312492,0.0021771966,-0.07450162,0.093983546,-0.12019609,-0.03529411,0.06331624,0.04430962,0.027972832,0.023143334,-0.067226425,0.042145513,0.0575232,-0.065911666,-0.01505019,0.05127543,0.07326842,-0.024998695,0.016596772,-0.03714194,0.032055132,-0.06199405,-0.0074718464,-0.020464523,0.01135233,-0.033816114,0.012399091,-3.6406329e-35,0.08710017,0.07195188,0.06279874,0.06360657,-0.053520035,0.02830947,-0.08992313,-0.061339848,-0.025678212,-0.07059124,0.00043297908,-0.01511844,-0.02588098,0.02499039,-0.035813894,-0.013384582,-0.022904335,-0.00208341,0.05462492,-0.029098703,0.024086574,0.035517965,-0.015462256,0.08085076,-0.014999307,0.057710044,0.041928485,0.036988795,-0.014397187,0.031299725,0.023568936,0.018150497,-0.025898797,0.008992647,-0.006635529,0.0888197,-0.12236708,-0.019530652,-0.006136441,0.009485504,-0.0017872258,0.030135153,0.008932185,-0.025277682,0.10865641,-0.08749338,-0.020098358,0.064708106,-0.017494978,0.044099182,0.00049068034,0.015474438,0.021682339,0.03858846,-0.005099398,0.016249705,-0.009263339,-0.010415693,0.06313147,0.033162296,-0.05505398,0.05695896,-0.03214734,0.08122639,-0.0396475,0.0339511,-0.065334454,-0.04883575,-0.016671086,-0.01880031,-0.050679795,-0.043328788,0.026527472,0.052278847,-0.005205164,-0.00082134316,-0.026675448,-0.04122416,-0.00070099183,-0.07958073,0.018568436,-0.1174832,0.041367024,0.018895688,0.035307955,-0.06889345,-0.074563004,0.014047569,-0.04675407,-0.02247306,0.075931326,-0.07694393,0.056592267,0.018622905,-0.024742909,-3.0976338e-34,-0.0047785,-0.076834954,0.057447124,-0.0057969014,-0.014474026,0.030772272,0.0945202,-0.14378883,0.052288745,-0.028331269,0.044354733,0.038584456,0.012538892,-0.03172735,-1.5328636e-05,0.05935679,0.017200835,-0.002139005,-0.0009321328,-0.058956876,0.019095773,0.039361775,0.027532905,0.021034632,0.0072659203,0.10040164,-0.009525995,0.0075747613,0.034451354,-0.0026984306,-0.036037236,-0.013357735,-0.09119725,-0.10997613,-0.07137618,-0.04155978,0.004990721,-0.016312368,-0.084673695,-0.11416893,-0.021455158,0.03192014,-0.004055424,0.06873264,0.027379876,-0.003932923,0.038886804,-0.087912194,0.04972663,0.08649469,-0.07793369,-0.038780093,-0.06379695,-0.045001365,0.0034848847,0.051831976,0.057951964,-0.02352264,0.01870731,0.024525061,0.0336345,0.04408862,0.002264462,-0.01929411,0.05458654,-0.012546877,0.004408355,0.09237885,0.10079628,0.029007599,0.071688324,0.11123632,0.044147313,-0.037082322,-0.01221554,0.0023528454,-0.063830376,1.673802e-05,0.0015362613,-0.017161772,-0.06615364,-0.06874318,0.03395075,0.004812233,0.03648512,-0.10323365,0.01878816,-0.100015536,-0.008090147,0.053209744,-0.036256045,-0.02722566,0.07696051,0.097078055,0.026715217,-1.741511e-08,-0.010199822,0.01861513,0.035917725,-0.08056874,0.025888583,0.05739062,0.025830803,-0.087280154,0.02316025,-0.04461164,0.053255923,0.06451939,0.06717605,0.13575932,0.029474813,-0.03062551,-0.035597406,-0.0482091,-0.07705939,-0.10077078,-0.13743322,-0.04989279,0.017520774,0.08046793,-0.00859756,-0.022249382,0.070680164,0.107999615,-0.015256744,0.05486184,-0.080060884,0.0019619109,0.04204455,-0.031282425,-0.05894243,0.032744445,0.039074477,0.03996152,-0.0059084296,-0.012840017,-0.052153334,0.07939738,-0.07015118,0.048632577,0.08869565,-0.011351803,-0.027252687,-0.008267795,-0.032294128,0.014521446,0.023376137,0.009664038,-0.04807141,0.022743119,-0.011551097,-0.015571258,-0.017558528,-0.022278218,0.016477384,-0.07322036,0.036243092,-0.04815458,0.12655243,-0.020703819 +5.4.99.9,"A flavoenzyme which generates UDP-alpha-D-glactofuranose required for cell wall formation in bacteria, fungi, and protozoa.",384,1.0,-0.08172915,-0.06285597,-0.107574016,-0.008679505,0.011404003,0.040437292,-0.019318687,0.063901365,0.004914597,0.021054728,-0.0016322061,-0.04455159,-0.08918088,0.057812154,-0.061306626,-0.03276104,0.006396727,0.033879884,-0.02261367,-0.0033644387,0.08264986,-0.00636476,0.04046252,-0.018114155,0.031209376,-0.028842263,0.023408541,-0.05189509,0.004844335,-0.08894268,0.024747975,0.018106887,0.0951935,-0.0729621,0.09368852,0.048184495,0.010074852,-0.03167503,0.057625927,0.021309558,0.015107712,0.015973687,0.046650358,-0.007288146,0.0032822317,0.044175837,-0.033573262,0.11422812,0.021179639,-0.038403258,-0.0288863,-0.03016231,-0.06638042,0.04154485,0.006681106,0.06845985,0.0037149882,0.0019531944,-0.0030315984,0.0032461162,0.05553739,-0.017029358,0.0557238,0.0010595232,-0.010699268,-0.020730712,-0.0057900487,-0.005719227,-0.0494223,0.07584298,-0.024522798,0.022067606,-0.04855011,0.04574742,0.041426897,0.10491057,-0.0216268,-0.035743114,0.014772374,0.059053708,0.09730237,-0.01652384,-0.0007151733,0.08525478,-0.018677847,-0.003417512,0.02069094,-0.0019480989,-0.002265215,0.050282262,-0.033093933,0.0667702,0.044320285,-0.00095594797,-0.07233221,0.046988733,0.06626133,0.0030635872,0.06443764,-0.066879414,-0.06631564,-0.09488594,0.06374315,-0.024538536,-0.08201621,-0.048733465,-0.041257475,-0.030703004,0.040249486,0.061849657,-0.017225407,0.020096641,0.00093631604,-0.07922796,-0.022466812,0.0070162527,0.037723176,-0.052771818,-0.019314678,-0.056858014,0.030943714,-0.024816694,0.04280604,0.04959398,-0.025561988,-0.011974378,0.00674982,-8.6305365e-34,0.10158872,0.029915482,-0.06862151,0.018710487,0.07900663,-0.061208647,-0.023796316,-0.08259763,-0.009231855,-0.027773196,-0.14629185,-0.021368809,0.018894665,0.068842515,-0.016984899,0.07354005,-0.013122285,-0.061870497,0.015983617,0.017645184,0.039284747,0.06794535,0.028447479,0.024972297,0.022950979,0.009961057,-0.054885566,0.0194695,0.00012509641,-0.008978382,-0.016231224,-0.098133564,-0.08101027,0.0321755,0.039756466,0.061091628,-0.14890318,-0.15442047,-0.022257434,-0.011414305,-0.014594752,-0.012423075,-0.021544002,0.0040244125,0.0350412,0.034578715,-0.08129324,0.0042735566,0.024855595,0.034638073,0.041387115,0.015071395,0.032599524,0.027752435,-0.03406501,0.015915615,-0.055610865,-0.009938534,0.04109209,0.04363515,0.004587236,0.10668609,-0.0018085109,0.04884965,-0.0648877,0.0019090739,-0.04404607,0.010273223,0.051288344,-0.056969997,0.04845396,-0.11945857,0.011467942,0.017731253,0.035910167,-0.024485428,0.008757031,-0.0023486693,0.0258743,-0.0028625266,0.005839726,-0.05079553,-0.030741518,-0.018627062,-0.051029686,0.042767417,-0.004692733,0.04746055,0.0012144746,0.041398436,0.02215562,-0.12805825,0.02132475,0.08787875,0.0019976185,-7.943079e-34,0.12329524,-0.08061206,0.034775443,0.020564644,-0.004104033,-0.012483816,0.0035729345,-0.03921773,-0.004252143,-0.009823175,0.0060577393,-0.042689342,-0.059201337,0.026369547,-0.025022367,-0.051857803,0.06747027,0.036141936,-0.013317107,0.010398554,-0.09335386,0.005229993,-0.018132363,0.04610649,0.037458494,-0.01587478,0.026536433,-0.0011259352,-0.08205776,0.014952196,-0.03449453,0.0502506,-0.06382344,-0.094700105,-0.0017966966,0.02606554,0.047783695,-0.045709927,-0.002309043,-0.036883917,-0.031258456,0.030887753,-0.024102205,0.032669213,0.09247546,0.11434549,-0.07238523,-0.0053709764,-0.0067834123,0.020857705,0.018887673,0.06774431,-0.022406237,0.004639258,0.0045353686,0.05513259,0.06275236,0.09979551,0.060398057,0.020881496,-0.0033222698,-0.1460997,0.034255918,-0.03966327,0.093276404,0.12056167,0.011066125,0.10291432,0.031078724,0.051000822,0.026105218,0.068537936,0.015838455,0.08909407,-0.027544618,-0.006257877,-0.08894211,-0.010342661,0.010887298,0.032924183,0.0019152312,-0.007973077,0.00052106933,0.0107708145,0.039053462,-0.13741429,0.06869046,0.043076906,-0.029870182,0.03629715,-0.011481235,-0.037921768,-0.039899517,0.016918808,0.08623471,-3.039726e-08,0.054928582,0.009811635,0.013383781,-0.0884257,0.052001055,-0.06776286,0.0022102203,0.01731365,0.07773504,-0.08193376,-0.07528968,0.12749313,0.02169182,0.05287926,0.039248023,0.010718592,-0.06562324,-0.0336394,-0.02216316,-0.014140354,-0.05292914,0.015687834,-0.15635124,0.02833228,-0.009218624,-0.053160056,0.054867875,0.022882452,0.03316096,-0.034906574,0.050899293,0.016103292,0.044003386,-0.046350695,-0.067359515,0.021953119,-0.011210933,-0.08254357,-0.0056490875,-0.009074134,-0.04739007,0.00040784985,0.019268217,-0.02471575,-0.033604342,-0.0041790362,-0.065924674,0.036075342,-0.07833229,-0.03538947,0.021204771,-0.04678303,-0.049026158,-0.0456123,-0.036587283,-0.086407945,0.029577859,-0.018901818,-0.015904577,-0.05879416,-0.08181073,-0.011583573,0.15709202,-0.053276107 +5.4.99.11,The enzyme simultaneously produces isomaltulose (6-O-alpha-D-glucopyranosyl-D-fructose) and smaller amounts of trehalulose (1-O-alpha-D-glucopyranosyl-beta-D-fructose) from sucrose.,384,0.9999999,0.005717584,-0.0887475,-0.13428135,0.030377433,-0.015674647,0.009370132,-0.0035549114,0.06040454,0.04265143,0.005384582,0.033864435,0.042439,-0.088599466,0.020660866,-0.058179226,-0.033092797,-0.024289237,0.018023059,-0.058927085,-0.07971472,0.12754391,-0.051966023,-0.020323088,-0.015465448,0.12442827,-0.05260356,-0.027968206,-0.058821823,0.0056700315,-0.053931616,-0.017953115,-0.09895718,0.07482313,-0.014100185,0.10087983,0.07830318,-0.029758906,-0.015075015,0.062785506,-0.0079383105,-0.037084572,-0.05168076,-0.032707937,0.012341186,-0.093577944,-0.044609893,-0.05537346,0.090054885,-0.0021615091,0.016121283,0.012818579,-0.062819615,-0.059131622,0.021615978,0.04420246,0.04280895,-0.025618002,-0.03933655,-0.019270813,0.043122817,0.011482116,0.027551413,-0.06754768,0.0075994427,0.01233607,-0.06777746,0.012315321,-0.053896204,0.018712144,-0.011919566,-0.022872536,-0.019193862,-0.009334115,0.055179413,-0.0038748276,-0.04332087,-0.028937027,-0.06541398,0.015541764,0.07171197,0.100784995,0.015068715,0.022409083,0.05229585,0.02658947,-0.07855097,0.04934588,0.06662438,0.060263824,-0.008011335,0.030536579,-0.020573013,-0.024121087,-0.027763903,-0.055037413,0.023976624,-0.00748037,0.044980854,0.035173908,-0.042537827,-0.0065146866,-0.020488838,0.064226344,-0.05350619,-0.033200517,0.017568512,-0.01911465,0.088747464,0.044353254,0.010234986,-0.049663328,0.010812092,0.062574014,0.06727672,-0.06947541,0.09109766,0.033455066,-0.05062903,0.007950236,-0.006500512,0.03721497,0.0824852,0.08384626,0.1007188,-0.0069890018,0.080546625,-0.013012678,1.0255119e-33,0.043085814,0.081238955,-0.021684837,-0.037007496,-0.030389696,-0.004208762,-0.0741804,0.012022405,-0.06998381,0.10589969,-0.09426932,-0.07437951,0.021048717,0.07115129,-0.0023503734,0.0141872885,0.032118805,0.01755926,0.04043697,-0.0055066105,-0.03851165,0.114518255,-0.012585378,0.05093693,-0.005587813,0.013337325,-0.046257116,0.10103996,0.055127762,-0.0104339775,0.0596695,0.0036070088,-0.02263408,-0.02406214,0.07324935,0.042154968,-0.055963423,0.0015398173,-0.049104292,0.05633328,0.07344857,0.038004078,-0.00021877389,-0.08149672,0.065992996,-0.05948508,-0.08985775,0.06460309,0.07615587,0.050760463,0.027869105,0.024132675,-0.0015436447,0.059614826,-0.010802758,0.033527106,0.013499953,-0.014773995,0.077717066,0.004153998,-0.043483473,0.014167568,-0.015693711,-0.043076508,-0.0038549695,-0.021345386,-0.028433124,-0.008316305,-0.08235832,0.055023644,-0.1226368,-0.029362578,-0.004285068,-0.010202508,0.06820244,-0.051711954,-0.024786776,-0.019374138,0.017146941,-0.07048263,-0.029179275,0.030531501,0.0008996808,-0.05120935,-0.06875126,-0.051009223,-0.1013704,0.0020787928,-0.0037960368,0.060306937,-0.071639515,-0.02510307,-0.11561343,0.060462024,0.0571417,-1.9023763e-33,0.05225628,-0.10600716,0.033582147,-0.07107556,-0.038198374,0.0535639,-0.020131331,-0.04870963,0.021632345,-0.0139434,0.07280417,-0.033354342,-0.04351153,-0.0071332213,0.009271845,-0.03084758,-0.009013547,0.055012845,-0.002203046,0.011705468,-0.039198224,0.07692785,0.03638073,0.003363579,0.07021834,0.01583489,0.07313812,0.06838958,0.017362382,0.040850986,0.022663513,-0.076307654,0.058099464,-0.0047463276,-0.086558506,0.045907397,-0.05279515,-0.009156999,-0.0045601316,0.023339063,-0.02680748,0.041834407,0.038876817,-0.008740442,0.051136885,0.025972586,-0.030099813,-0.052047253,-0.03624841,-0.056502752,0.020822065,0.008538186,-0.06438451,0.003622477,0.010489213,0.01700578,-0.028651606,0.025700951,-0.01902167,-0.08559242,0.0065319636,-0.034646347,0.047452163,-0.06411854,0.1052277,0.03416461,-0.03825251,0.05839232,-0.0029181973,0.06585342,-0.031000134,-0.009047169,-0.05194776,0.047874633,0.04382662,-0.10822896,-0.1458466,-0.0006130597,-0.005252642,-0.04007393,-0.050040312,0.038287062,-0.00066143187,-0.033294823,0.009946229,-0.032473553,0.010060303,0.110544376,0.05027265,0.07869593,-0.08260192,0.011303398,0.020874085,-0.00074130204,0.14624694,-3.5503746e-08,0.043869104,-0.019633416,-0.06504918,-0.05344896,-0.0011073436,0.010272937,-0.019143097,0.016750671,-0.038715273,-0.015285904,-0.02887923,0.16589221,-0.026680045,0.027792996,-0.0068493206,0.002758394,-0.06698009,-0.00953721,0.03017771,-0.03020835,-0.043066293,0.020711886,-0.04518352,0.033291638,-0.009249311,-0.04448992,0.03149307,0.102588154,-0.041725937,0.023277985,0.04954537,0.03285374,0.005090128,-0.029079255,-0.028962761,0.07505226,-0.06852588,-0.018298708,-0.0020630204,0.024050094,0.06135089,-0.038296275,-0.033872187,0.030386118,-0.036580145,-0.0058925776,0.044456903,-0.009370396,0.01579296,0.06101401,-0.0049788733,-0.047963955,-0.081757426,-0.036382224,-0.023583923,-0.008690712,-0.015627695,-0.056462765,-0.022315353,-0.030404624,0.054663867,-0.0557501,0.16899467,-0.06290985 +5.4.99.12,"The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine. TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures [1]. ",384,1.0,-0.048114534,-0.067014664,-0.08425936,-0.10131957,-0.0322192,-0.051203914,-0.014132492,0.04787523,-0.0075239833,0.050415907,0.11290145,0.030770866,-0.077531055,0.039655834,-0.08730067,-0.024674527,-0.13316841,0.03344952,0.059470262,0.00700279,0.08008584,0.12302931,-0.03661616,0.03966275,0.014358893,0.008024918,0.03245119,-0.017687308,0.05564972,-0.07569446,-0.09176713,-0.06440737,0.056506563,-0.05721128,0.028504325,-0.02768404,-0.1036258,0.009851056,0.107184395,0.049044456,0.06432307,-0.0051609087,0.013787592,-0.08851244,-0.08440437,0.0010977574,-0.017166682,0.03808252,-0.039361794,0.07893958,-0.005976577,0.025254773,-0.046296228,0.08422279,-0.06924193,0.024224969,-0.06823259,0.002862611,0.010602864,0.022166895,0.061740447,0.036218103,0.009343999,-0.06224762,0.014630827,-0.015401971,0.034927156,-0.017202973,0.088465475,-0.012903939,-0.010677083,0.024257727,0.030779783,0.029217226,0.0075871674,0.0065534064,0.00025205256,-0.030039202,-0.083747044,-0.0029535524,-0.028101938,-0.12315374,0.10171171,0.040675264,0.022172796,-0.024425566,-0.018617664,0.03698968,0.018707274,0.01675151,0.07628172,0.04594038,0.0079664085,-0.042699188,-0.00056872325,0.043933056,0.0261366,0.081824996,-0.011914899,-0.023666931,0.030621842,0.003640397,-0.09364321,-0.068464875,0.020616906,-0.04071299,0.019281628,0.0029643944,-0.02747023,-0.0123949265,-0.0027123357,0.048141714,0.08964361,0.024621114,-0.05847391,-0.02776235,0.032606013,-0.036509573,0.0045092464,-0.05700125,-0.019778496,0.020287229,0.049052354,0.07049818,-0.014634569,-0.00062347774,-0.05197366,1.4341185e-33,0.0036550136,0.07760249,0.033292063,-0.027409429,-0.027766865,-0.0052833064,-0.030980708,-0.051269423,-0.019925142,-0.08285261,-0.10550276,0.012206311,-0.009356437,-0.031253483,-0.04088889,-0.09367677,-0.0043429746,0.078132585,0.014991224,-0.07815824,0.04415504,0.1526688,-0.027200328,-0.01822256,0.04667855,0.0194573,-0.032518364,0.00949544,0.030960744,0.024956286,0.007304352,0.006501984,-0.07252063,-0.010251642,0.12646778,-0.0044068494,-0.032972597,-0.039282545,-0.092945784,0.06602895,0.035011828,0.00466807,0.0045680613,0.003661447,-0.00088614714,-0.046564907,0.011314519,0.059388142,-0.075920396,0.04225019,-0.066881515,-0.010847558,-0.037256256,0.005554371,-0.06489045,-0.078266196,-0.011531165,-0.09001905,0.04937701,0.09050372,0.03821578,0.042859085,-0.04083715,0.03486633,-0.06343084,-0.018657578,-0.06657862,-0.048344277,0.06599108,0.050998926,-0.041680608,-0.065699875,0.030541988,0.039833937,0.0055403267,-0.038764596,-0.079350896,0.018379208,-0.02236471,-0.015239341,-0.0024638823,-0.019162674,-0.018279972,0.015425114,-0.00929093,-0.04305174,0.027425488,-0.0092273215,-0.002503881,-0.011097125,0.05969439,-0.026748613,-0.060332842,0.013042479,0.031474076,-2.5400001e-33,0.12798971,-0.10802694,0.091213204,0.020891879,-0.08124017,0.024405994,0.04520215,-0.019627035,-0.01806828,-0.09110849,0.10938062,0.04621983,-0.039866105,-0.044759646,0.007153099,-0.03712393,0.08916315,-0.011332493,-0.031747635,-0.06098541,-0.01450731,-0.024541074,0.0008180598,0.07685435,0.006175769,0.0053474596,0.02225622,-0.001011984,0.048518986,0.05886962,0.0032789703,0.024269888,-0.020993855,0.0011678387,-0.04510481,0.05659402,-0.050088152,0.025273127,0.06427675,-0.049161807,0.05227194,-0.07871219,-0.027236374,0.04204223,-0.0045127166,-2.969503e-05,-0.050649147,0.0057998486,-0.08833852,-0.09517833,0.036929492,0.043042544,0.08520051,-0.03130311,0.06983999,-0.009370234,-0.10955384,-0.002059636,-0.04531445,0.024416095,0.017790584,0.019764643,-0.015477441,-0.10331072,0.059836894,-0.023947218,-0.026596157,0.041809544,-0.026704853,-0.035253942,0.007923482,-0.02605688,-0.0044072103,-0.0029807466,-0.007088439,-0.11530428,-0.013235261,-0.028995702,0.0500381,-0.04667434,-0.043770358,-0.029804507,0.020025242,-0.04173143,0.03503648,0.034243017,0.025353698,0.08335406,-0.01483278,0.048887245,0.04163124,-0.009530154,0.047544573,0.03863252,0.08214285,-3.4751164e-08,0.023513854,0.004647625,-0.008503165,0.011354307,-0.040242095,0.075504795,-0.059499487,0.07061883,0.0037925765,0.0037755617,0.044374187,0.035088927,0.018084772,0.057623323,0.023640659,0.08337564,-0.117205195,0.02833724,0.016058674,0.0059154187,-0.10077609,0.015251307,-0.13051413,-0.039590664,-0.002917417,0.058271725,0.06190205,0.020408846,-0.04785551,-0.015836172,0.06743339,-0.07675269,-0.013268111,0.03926612,0.022444833,0.08873094,0.032743916,-0.0005720615,-0.06763033,0.00642006,0.025035603,0.015610083,-0.096467406,0.0412844,0.005067712,0.015640339,-0.02026019,0.08618199,-0.064592235,-0.0029555617,0.035436284,0.050665464,0.030738795,-0.038455483,0.0021155775,0.009569443,0.03729016,-0.06842383,-0.08211182,0.12146057,0.07793991,-0.0018912565,0.05175362,0.03001598 +5.4.99.13,"This bacterial enzyme utilizes 5'-deoxyadenosylcobalamin as a cofactor. Following substrate binding, the enzyme catalyses the homolytic cleavage of the cobalt-carbon bond of AdoCbl, yielding cob(II)alamin and a 5'-deoxyadenosyl radical, which initiates the the carbon skeleton rearrangement reaction by hydrogen atom abstraction from the substrate. At the end of each catalytic cycle the 5'-deoxyadenosyl radical and cob(II)alamin recombine, regenerating the resting form of the cofactor. The enzyme is prone to inactivation resulting from occassional loss of the 5'-deoxyadenosyl molecule. Inactivated enzymes are repaired by the action of EC 2.5.1.17, cob(I)yrinic acid a,c-diamide adenosyltransferase, and a G-protein chaperone, which restore cob(II)alamin (which is first reduced to cob(I)alamin by an unidentified reductase) to 5'-deoxyadenosylcobalamin and load it back on the mutase. Some mutases are fused with their G-protein chaperone. These enzyme can also catalyse the interconversion of isovaleryl-CoA with pivalyl-CoA.",384,1.0,-0.095894486,-0.08908773,-0.051260814,-0.019905683,0.034019507,-0.021903377,-0.09116563,-0.038491998,0.004476999,-0.016155872,0.04187742,-0.012174702,-0.05861864,0.025146892,0.015474508,0.066980764,-0.034535658,0.010789866,-0.059834335,-0.0771802,-0.032864064,-0.011539682,-0.0672229,0.0044985344,0.025861539,0.03942515,0.059220698,0.023356158,-0.07283573,-0.1034897,0.016565176,-0.053758185,0.008809015,-0.021142084,0.0047142315,0.10499598,-0.019501552,-0.053913616,0.08546501,0.016133381,-0.037583854,0.07277729,-0.035193782,0.012540049,0.0077923764,-0.042067427,-0.0013679613,0.024634965,0.07184621,-0.054556396,-0.04035996,0.0023372446,-0.028264612,0.06869638,0.03242732,0.017901817,-0.032459088,-0.010160662,0.028448751,-0.03237562,0.007199211,-0.046641696,0.07212984,-0.01936671,-0.012774134,-0.020801764,0.030159213,-0.08749948,0.036097504,0.00417704,-0.035194222,-0.076291494,0.02268848,-0.0012763949,-0.033808693,0.058861036,-0.0043472233,-0.046724405,0.033407114,0.00056673895,-0.018286293,0.06434538,0.08230184,0.03432491,0.058244403,-0.049872134,0.003565053,-0.0178462,0.01390402,0.059437927,0.04040751,-0.0023103827,0.017418217,-0.041645385,-0.042234685,-0.010204051,0.03596559,0.08815721,-0.020290611,-0.032483775,-0.0032363057,0.063540265,-0.038123954,-0.07142567,-0.008990073,-0.03119141,0.06386742,0.14960946,0.06365509,0.02516758,0.010562289,0.06972407,0.024284411,0.018909302,0.013023958,0.13015252,0.047906976,-0.010885884,-0.027211396,0.015577517,0.081257805,-0.007504622,0.061697006,0.007825197,-0.08134114,0.029716447,-0.06365673,4.254082e-33,0.043340426,0.020428805,0.003687127,0.03940461,-0.0005763151,-0.08592239,-0.16428076,0.0873146,-0.052155044,-0.029781165,-0.023771789,-0.020161783,0.0948378,-0.051230203,-0.07793552,-0.08733411,-0.04719696,-0.049424548,0.022138113,0.052508745,0.010892209,0.040612403,-0.026265407,0.039422374,0.0038080523,0.072886094,0.033458266,0.04029889,-0.009837976,0.03282394,-0.06616964,-0.08309023,-0.07552965,-0.012389471,0.0041102935,-0.07059469,-0.038139265,0.0018382703,-0.023509389,-0.0011533535,-0.0070016393,0.019595124,-0.07159255,0.0013423818,0.12378449,-0.07376979,0.02868614,0.11895114,0.014063434,0.05662247,0.0019026372,-0.017194407,0.10833705,-0.011650831,-0.0757519,0.03050879,0.014556924,-0.026993394,0.026488505,0.07796225,0.048054554,0.072559044,-0.07519274,0.051137086,-0.0348545,0.09186784,-0.05825733,-0.049049478,-0.005954557,0.053826515,-0.030947277,0.003774431,0.07480717,0.11230197,-0.0048913425,-0.010940479,0.023584817,-0.025631944,0.045037348,-0.027740572,-0.04790767,-0.021954956,0.02319112,0.006479433,-0.028161922,-0.008020671,-0.034545217,-0.03175487,-0.037812866,0.021709414,0.055459533,-0.064412884,-0.016589496,-0.01031372,0.00042441566,-5.107548e-33,0.13507827,-0.122666314,0.00735199,-0.12803833,-0.0878754,0.06470623,0.0076823994,-0.027013246,0.028094264,-0.051689744,0.055581838,-0.007458352,0.040419497,0.026317302,0.0027954348,0.03296348,-0.07481224,0.038069457,-0.055138327,-0.021602137,0.106598936,0.045910932,0.0485112,-0.022810781,0.0265387,0.060685672,0.024923818,0.053432234,0.088314235,0.06133051,-0.0558075,-0.016150806,-0.041584622,-0.059231758,-0.0041935677,0.037679654,-0.08552318,0.0065024984,-0.036669858,-0.008845438,-0.035582274,0.041231308,-0.06288999,0.08780832,0.045615055,0.09223531,-0.09319939,0.032850508,-0.010644839,-0.028559165,0.006853342,0.013157823,-0.06388836,-0.0032993786,-0.042567857,0.045830034,0.061770227,0.0073185447,0.0014230643,0.016709657,-0.06456929,-0.053528536,0.06374014,-0.0022726005,0.04095005,0.015833795,0.048762012,0.07326166,0.052872244,-0.01286905,0.03607049,0.0074775806,-0.016031442,0.0020713639,-0.015849235,0.041302636,-0.060902834,-0.038946457,0.00853751,0.00020813564,-0.07687838,-0.016694069,-0.015881058,-0.031098552,0.01250813,-0.034656335,0.0529134,0.11448897,-0.01560865,0.016650308,-0.04231567,-0.06542743,-0.06001332,0.016506508,0.02250637,-4.9141125e-08,-0.015565071,-0.026082415,0.08275358,-0.023435468,0.056679722,0.10236451,-0.030982753,-0.016258579,0.06273728,-0.046638336,0.039934322,0.1116513,-0.021530155,0.050880473,-0.09793932,0.013489178,-0.05831705,-0.034456108,0.034452982,-0.038174834,-0.04987312,-0.049430486,-0.05653493,0.026499156,0.0121250115,-0.087194696,-0.024065934,0.08106121,-0.06466175,-0.09036231,-0.007018804,0.04216931,0.02557932,-0.033966567,-0.09122632,-0.018800622,-0.059160378,-0.0018972115,-0.052027475,0.05179231,-0.011150535,-0.034888312,-0.07491764,0.023622349,0.025791597,0.029179929,0.015469491,0.057486992,0.00506323,-0.018850688,0.08422718,-0.047487393,-0.03124078,0.0024506361,-0.09542229,0.015388345,-0.020343099,-0.10163366,0.009011466,-0.012994367,-0.0112390565,0.013147903,0.08338056,-0.08698915 +5.4.99.15,"The enzyme from Arthrobacter sp., Sulfolobus acidocaldarius acts on (1->4)-alpha-D-glucans containing three or more (1->4)-alpha-linked D-glucose units. Not active towards maltose.",384,1.0,0.013075235,-0.11026899,-0.08933523,0.0006483946,-0.067207284,0.053060755,-0.009882283,-0.021825245,0.03637804,0.010369125,0.0050557954,0.03630666,-0.09583895,0.009310428,-0.03942652,0.057298575,-0.043467566,-0.0053631025,-0.009540683,-0.032439824,0.07088026,-0.032082815,-0.012906547,-0.046546597,0.012542112,0.053024244,0.060989104,-0.030454032,-0.062400088,-0.05285749,-0.006547784,-0.10240036,0.09568251,0.027418032,0.045371637,0.084537886,-0.036839318,-0.039571848,-0.021322109,-0.008221658,0.061599433,-0.010094378,-0.0067445696,0.028995091,-0.12540272,-0.04003527,-0.10551157,0.032900803,0.030177696,0.00930923,-0.05250104,-0.10649483,-0.05889236,0.031528402,0.026378129,0.0044880663,-0.024036445,0.008039433,0.0022786544,-0.006735325,-0.007020595,0.11779847,0.044147037,-0.0020110395,-0.0041226707,-0.032367554,0.030485256,-0.030535754,-0.08196899,-0.015544628,-0.06664103,-0.050694652,-0.0315041,0.04698112,0.0033100066,-0.009156087,-0.047769677,-0.053544275,0.06862881,-0.03842597,0.021223083,0.0007461778,0.0524767,0.10636666,-0.072664365,-0.06537224,0.018103391,-0.03180064,0.07661537,-0.0022613162,0.052190725,-0.059378278,-0.058210928,-0.05582425,0.0034648299,-0.009622386,0.013460458,0.0046349806,0.0029894484,-0.037037864,-0.016407155,0.023369718,0.012451518,-0.069455415,-0.104121216,0.029521242,-0.0521762,0.08612729,0.012421262,0.007695589,-0.015105211,0.012549907,0.034238838,-0.0130882235,-0.113515764,0.026727015,0.015587664,-0.0721458,-0.06935514,-0.043601107,-0.023914453,0.014454784,0.104452744,0.017866515,-0.02048907,0.050696228,-0.0817301,-1.1400401e-33,0.13688731,-0.061554797,0.03622344,-0.04772073,-0.053262178,-0.02350428,-0.07270722,0.048547063,0.00076649466,0.042325035,-0.10264528,-0.06484314,0.071237504,0.053577024,0.026258158,0.101038754,0.0011466643,-0.0724767,0.03985797,0.06968995,0.010595321,0.06556556,-0.001188226,-0.0028429383,-0.018928247,0.09585906,-0.026673676,0.027669294,0.03128305,-0.006562098,0.03629573,-0.058639828,-0.07163795,0.04022189,0.06587538,0.07583658,-0.045501523,0.0033612512,-0.029024638,-0.012964816,0.03564303,0.0010429133,0.058199804,-0.07232572,0.08175526,0.008848711,-0.031616278,0.037846893,0.021632606,0.10846212,0.033897437,-0.013911537,0.052432396,0.04086,-0.041995227,0.033488564,-0.035226047,0.021804249,-0.0026389817,0.012547254,0.030740995,0.035577647,0.023341551,-0.03361123,-0.005827028,0.021161633,-0.079864964,-0.02297739,-0.047860052,0.072589636,-0.0626352,-0.063423984,0.034423757,0.0023783494,-0.030407928,-0.04450538,0.0019962387,-0.010047185,-0.009181383,-0.026490731,-0.0050373087,-0.07063778,0.059786297,-0.00024858504,-0.08725664,0.014192522,-0.08135848,-0.023481045,-0.11298914,0.03268896,0.0057043247,0.02174564,-0.09079513,0.075576976,0.025398072,-2.839328e-33,0.10048585,-0.085721344,0.02764634,-0.06832173,-0.019494176,0.073918924,0.07094213,0.027565215,-0.0010101957,0.04876042,0.06589919,0.08878931,-0.02400091,-0.07747375,0.051782895,0.07297661,-0.016392428,0.06314598,-0.04261544,-0.017076971,-0.052098185,0.18215866,0.009864666,-0.01399681,0.056358077,-0.04066376,0.0914343,0.085098356,0.0078407135,-0.0024590848,0.088106796,0.027913442,0.0059074275,-0.038689297,-0.05907618,0.009496962,-0.037351523,-0.052218538,-0.0033326745,0.030860385,-0.002138026,0.055435296,0.009731699,0.10657262,0.084406346,0.042254556,-0.09033075,0.014120282,-0.022981135,-0.031658314,-0.015625885,-0.0390738,-0.0013147764,-0.0041018943,0.04069927,0.08791892,0.01436321,-0.013047855,-0.0632042,-0.011597122,-0.06664384,-0.003181172,0.082464695,-0.09360944,-0.01744207,0.051368378,0.034324937,0.030831575,0.04979554,0.017233988,0.042554207,-0.03103316,-0.048266657,0.025144434,-0.029973589,-0.059189864,-0.09884228,0.036410097,0.02718229,-0.032241832,-0.0063605015,0.054450113,0.0369102,-0.03243851,0.060677618,-0.056693535,-0.03401644,0.09092271,-0.014052012,0.08330752,-0.04208845,0.0015336936,0.025400626,-0.009277781,0.012351479,-3.715372e-08,0.03234405,0.01834076,-0.02521013,-0.01823521,-0.027721789,0.026594155,-0.030900106,0.04031556,0.001315777,0.019601112,0.019088635,0.093669556,-0.076272495,0.048410725,0.046530474,-0.0037115556,-0.01521956,0.017073719,-0.069140084,0.013831374,-0.11060393,-0.024664873,-0.10992076,0.01612139,-0.0036600705,-0.09911322,0.049559023,-0.027067287,-0.052185237,0.046697523,0.009096488,0.068790935,-0.009166192,-0.089339904,-0.02202498,0.022311457,-0.057974856,-0.047870863,0.023452898,0.029277947,0.052406434,-0.0050811633,-0.03856217,0.009836095,-0.0033757463,0.012271217,-0.034645077,-0.024833988,-0.022666875,0.07734906,0.01031077,0.033965454,-0.0670473,-0.031173922,-0.035929628,-0.012944152,-0.0078121936,-0.09084041,0.009969067,-0.043365356,0.065351345,-0.04544072,0.09239723,-0.013957158 +5.4.99.17,"The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129, squaleneβ€”hopanol cyclase). Hopene and hopanol are formed at a constant ratio of 5:1. ",384,1.0,-0.09209064,0.0336737,-0.07179786,-0.0022628065,0.053368658,-0.016390176,-0.0065022223,0.046146926,0.03440975,0.014251422,0.023822,-0.036946747,-0.044894215,0.020469949,-0.0886836,0.018649276,-0.12040753,0.05929785,-0.061346907,-0.08178387,0.070056126,-0.0151002845,0.021178845,0.08725055,0.026895652,-0.0443827,-0.0112508405,0.022396844,0.005832784,0.00032340697,0.037344564,0.02297406,0.040158253,-0.08884596,-0.004340014,-0.0041744774,-0.06711894,0.013462229,-0.049931154,-0.044578202,0.05847247,-0.0072467076,-0.028493835,0.01842329,-0.0023993088,-0.018285371,0.024926694,0.04401125,-0.0011123497,-0.019169632,-0.04167011,-0.040626533,-0.08047661,0.025031652,-0.014556124,0.034585625,-0.09829354,0.028110737,0.043510437,0.005373165,0.028771954,0.029794669,-0.061669074,-0.04301159,-0.021262866,-0.035009623,-0.031450726,-0.010957186,-0.01041916,-0.0016283384,0.0017113312,-0.030262407,-0.03143018,-0.0050358274,-0.0051640226,0.067774415,0.029469546,-0.03162128,-0.00020492835,0.056927666,0.022014517,-0.0027901423,0.008070084,0.019346766,-0.0036636088,0.081858486,0.05328674,0.027933633,0.045709256,-0.005973987,0.030264976,0.03175991,-0.1021308,-0.08109746,0.031724796,0.029961,0.03601224,-0.0056235646,0.06259997,0.01854276,0.020405559,-0.07995455,0.03583659,-0.14238203,-0.09549959,0.083403885,0.119554706,0.05919929,0.05380106,0.050908025,-0.026225153,-0.03506191,0.023319481,-0.010646978,-0.024306856,0.14567661,-0.03861078,-0.03750308,-0.0074217767,0.01247074,-0.02043205,0.04157493,0.06361322,0.048570197,-0.03617561,0.0385479,-0.027150417,1.2985201e-33,0.035454985,0.040743057,0.028054303,0.018039666,-0.021272717,0.05198335,-0.043140776,-0.04257684,-0.05871656,-0.061856028,-0.1201545,-0.050148435,0.000999499,-0.01953127,-0.060989443,-0.06294102,0.02054073,-0.0037110306,0.04676229,0.0044745817,-0.0549192,0.027650155,-0.12595314,-0.021730024,0.01853476,-0.03352802,0.009043621,-0.011209905,0.03850973,-0.042461425,0.010372243,-0.027064497,-0.04734101,-0.023474319,0.05302809,0.029041495,-0.012467797,-0.008757992,0.07263472,0.060736254,0.010044309,0.0057779686,0.059825927,0.0063366084,0.04387503,-0.034541354,-0.04874078,0.04389653,0.06526482,0.018322622,0.059669178,0.048286006,0.015739068,-0.030447504,-0.050378997,0.047688663,0.025250142,-0.01619656,0.08435386,0.02845658,-0.036667876,0.08566042,-0.043101743,-0.04836415,0.010904695,0.09702519,-0.06330449,0.0019010672,-0.04198879,0.01580016,-0.08993522,0.000658319,0.037659083,-0.012171056,0.05850834,0.023428183,-0.007788454,-0.013856034,0.09147803,-0.008791927,-0.05277672,-0.017916804,-0.06473423,0.0065297955,-0.06313174,-0.049630243,-0.07289689,-0.046734087,0.04349821,0.1314454,0.08149429,-0.12899713,-0.03060695,0.033053286,-0.034290373,-1.9162775e-33,0.050539296,-0.028091878,0.041492872,-0.022239314,0.017009152,0.069018096,0.033422768,-0.10333475,-0.014089636,-0.03400566,0.09934988,-0.039984323,0.061554465,0.012400697,-0.013086239,-0.0038024143,0.038990505,0.08754616,0.029575855,0.006075633,-0.027018733,0.015850505,-0.023813544,0.0015967007,0.031703707,-0.0018111449,0.034655664,0.0954934,0.1161568,0.039201595,-0.015824316,-0.08138777,-0.037926387,0.024593677,0.017432142,0.05488677,0.014080495,-0.03334516,0.023787072,-0.03751272,-0.054558586,-0.09181917,0.022238126,0.077834524,0.049633596,0.09688776,0.06533246,-0.00811861,-0.04892817,-0.074640706,0.09902348,0.08299966,-0.076869875,0.058218747,0.030249903,0.03405792,0.060959056,0.011486141,-0.05828057,-0.04875232,-0.011421402,-0.12239001,-0.0064782086,-0.059828408,0.02411806,-0.0009023744,-0.056605816,0.09410841,0.0035634,-0.021337735,0.053384427,-0.0016303008,0.07141862,0.010822547,-0.03654346,-0.021110546,0.06469416,-0.067495875,0.044463884,-0.07838096,-0.018465457,0.040744286,-0.020479036,-0.08476378,0.0056212884,-0.073926985,0.057421472,0.0540405,0.030157555,0.068513684,-0.021318851,0.016713917,-0.09954915,0.104121864,0.10629988,-3.3232865e-08,-0.0075405454,-0.093089916,0.041418534,-0.0045661377,-0.041197833,0.027302273,0.121330105,0.01739887,-0.0006608945,-0.018550832,-0.032702807,0.05908493,-0.028766662,-0.061285764,0.07470772,0.023331229,-0.05006103,0.030855702,0.02806262,-0.060894027,-0.046126936,-0.02160614,-0.12168359,-0.044727724,-0.10585594,-0.11758761,0.022982942,0.059726752,-0.06149477,-0.05330455,0.036970347,-0.004029197,-0.008179907,0.009260723,0.006038224,-0.0013387069,-0.098962896,0.047002923,0.015070524,-0.027472764,-0.051416468,0.013723518,-0.0480073,-0.027323678,0.0054179933,-0.03497258,0.031405613,-0.011514606,0.0123504745,-0.0027341624,0.030053526,0.035289418,0.0664533,-0.041327585,0.0227049,0.0072484044,0.007819286,-0.030627454,-0.033381794,-0.03243712,-0.04531989,-0.050967567,0.14189419,0.0148250675 +5.5.1.1,"Requires Mn2+. Also acts (in the reverse reaction) on 3-methyl-cis,cis-muconate and, very slowly, on cis,trans-muconate. Not identical with EC 5.5.1.7 (chloromuconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase).",384,1.0,-0.050600413,-0.046769354,-0.019761423,-0.0044208667,0.09380235,-0.029426577,0.0058140242,0.015689025,0.025082838,0.006620465,0.06317646,-0.043969944,0.023903238,0.027022451,-0.022638464,0.060258638,-0.0006061606,0.050916955,-0.029745027,-0.02607228,0.053472906,0.0040901755,0.02181976,-0.023340553,0.020629453,0.055569913,-0.0020425173,0.040800847,0.017318299,-0.06528505,0.0005826735,0.058291107,0.05209865,-0.07498841,-0.013210671,0.11264274,-0.0226205,-0.0388629,0.02416419,0.039462645,-0.0008916635,0.019482197,0.050688095,-0.0036332924,0.025021449,-0.07611568,0.017555023,-0.03448438,-0.0062487177,0.04340944,-0.03448253,0.0011414443,-0.0675676,0.043001287,-0.046912957,0.054949436,-0.08461348,0.03274657,-0.015398074,-0.020995459,0.009614197,-0.011505189,-0.05088165,0.018657643,-0.037691277,0.020891923,-0.007934567,-0.1091162,-0.0010127837,0.005638524,0.0052400893,-0.101209685,-0.031546872,0.04759894,0.015109128,0.0071536885,0.05938007,-0.072052926,-0.07334997,0.009442869,-0.07787442,-0.0064380625,0.13225849,-0.022243362,0.08028055,0.04005449,0.015331279,0.0107747475,0.006777663,-0.00067802524,0.07126635,0.021601979,0.008133803,-0.0059565646,0.015412898,0.07048549,-0.08795475,0.08953499,0.03266935,-0.026258165,0.023803178,0.04413569,-0.14332242,-0.017998435,0.048542596,-0.019459197,0.057382386,0.07621441,-0.099014275,-0.0071095596,0.010558736,-0.057437003,-0.00066851266,-0.030431071,0.02516721,0.0439112,0.09120174,-0.048270665,-0.013452868,-0.009496128,0.051926304,0.009281879,-0.028357802,-0.007748509,-0.093481585,0.0862042,-0.034220617,3.1829955e-33,-0.004605111,0.01374573,0.030252052,0.03581584,-0.039420735,0.06239211,-0.0466861,-0.056147806,-0.015748577,-0.116530314,-0.02277944,-0.040307082,-0.0034512475,0.0066725714,-0.08543064,-0.07771089,0.03361014,-0.011749547,0.056234505,-0.05116458,0.08359049,0.067909814,-0.084483646,0.027947396,-0.04584552,0.06457706,0.09190875,-0.026412902,0.10241652,-0.020375386,-0.054688152,-0.067011006,-0.04779193,-0.009457311,0.005882069,0.14162013,-0.05072125,0.03335442,0.025634378,0.02659763,-0.04638357,0.057520334,-0.061019592,0.004208703,0.102301024,-0.022781136,-0.060020972,0.041015763,0.012456862,0.014933707,-0.008367495,-0.0127568245,0.0018634528,0.055350613,-0.03461138,0.05421944,0.015314014,0.055196017,0.03135631,0.08100544,-0.07938361,0.0074951416,-0.045329437,0.08539585,0.08478225,0.029035667,-0.05787605,-0.042808823,-0.07111481,0.02262032,-0.0311821,-0.059163067,0.057027634,0.053714074,0.0804968,-0.08126533,-0.08003939,-0.047615875,0.03689432,0.051659312,-0.039853193,-0.023993053,-0.008879867,-0.01404226,-0.075870484,-0.0053257667,0.0010068631,-0.057653733,0.054838985,0.068439074,0.0727473,-0.057984974,-0.008763444,0.058095228,-0.030472994,-2.6944948e-33,0.018712126,-0.07563802,0.076846674,0.07908359,-0.06954029,0.015510153,-0.028016219,-0.1444271,0.031996347,0.034839954,0.09582838,-0.08510589,-0.07064986,-0.024279851,-0.040215306,-0.044983324,0.0640413,0.103658035,0.018228097,0.08626679,0.007676033,0.06749422,0.04638294,0.07133034,0.041772943,0.04765089,0.043177187,0.026532609,0.06622063,-0.03585009,-0.10036999,0.001063197,-0.03369616,-0.05074195,-0.0033403507,0.037454642,-0.08470142,0.009625864,-0.019137165,0.019793376,-0.034562383,-0.021494953,0.016603399,0.08968216,-0.026978647,0.005672014,-0.04136791,0.036953256,0.017110966,-0.06160251,-0.05068987,-0.02303634,-0.06877052,0.010032981,0.052273247,-0.0377526,0.05272042,0.044200145,0.08841086,0.01933284,0.04389867,0.033636544,0.011816315,-0.11511777,0.11421829,0.053739935,-0.055639524,0.057432313,0.034767114,0.048561975,-0.0031286082,0.02795753,0.07783987,-0.08231908,-0.03016118,-0.07620126,-0.06949679,-0.007954405,0.00075755175,-0.05589238,0.01582126,-0.012710629,0.00483835,0.0064609516,-0.018496137,-0.07530946,0.028715052,0.062021207,-0.06534355,0.05999526,-0.005247643,-0.07306761,0.015430039,0.06743516,0.07385136,-4.115862e-08,-0.02211566,-0.03969359,0.0144693665,-0.071501166,-0.010219183,0.03065196,-0.016514994,-0.042686414,0.08723544,-0.0019689498,0.021292923,0.024395015,0.057914022,0.046393763,-0.004700643,0.033300243,0.020823399,-0.019983962,0.038639035,-0.0002070974,-0.08875849,-0.027953725,-0.11428136,0.01612962,-0.014358195,0.014213217,0.0685444,0.065157734,0.008325709,-0.023345578,0.011140322,-0.037836652,-0.010544072,0.0053392625,-0.024113376,0.032263592,-0.025002187,-0.049997814,-0.007901776,-0.034555085,-0.068975076,-0.0045810733,-0.052569542,0.060918912,-0.026510285,-0.09703413,-0.004222033,0.0068022446,-0.039433066,-0.053565368,0.01819404,-0.102521494,0.04491851,-0.06281796,-0.021356087,0.07363323,0.063571624,-0.02882442,-0.0024658563,-0.006365366,-0.02450196,-0.063246705,0.06704043,-0.053428624 +5.5.1.4,"Requires NAD+, which dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.",384,0.99999994,-0.098070025,-0.040134985,-0.012001905,0.01741802,-0.0073609105,0.059439793,-0.06494603,-0.009026161,-0.037213806,0.04986661,-0.0035312711,-0.028236572,-0.14732265,-0.024438122,-0.035245232,0.04439662,-0.10173521,0.0058587347,0.0016982903,-0.0256011,0.0075232373,-0.09172493,0.00652356,-0.013619267,0.065008864,-0.012900318,0.050216787,0.012325496,0.03438134,-0.049354304,-0.042981178,0.012014226,0.0101485355,0.0022048466,-0.03953985,0.13042356,0.026947727,0.01476626,0.0066254786,-0.004143619,0.023294585,-0.009165496,0.0009344315,0.012029281,0.004835916,-0.09918273,-0.011712279,0.08372739,0.053408857,-0.0021825903,-0.027455034,0.023692224,-0.058621544,0.013686069,-0.0004113598,0.061864205,-0.03507362,-0.055047616,0.037283197,-0.11985393,-0.024250843,-0.023524726,-0.04573397,-0.004574849,0.026793003,-0.072692715,0.05333482,-0.048353642,-0.053989343,0.026380075,-0.07246433,-0.049657583,-0.026454782,-0.023353,-0.016607534,0.050691523,-0.09681615,-0.09228859,0.09344131,0.0136929285,0.034845345,0.043896627,0.018040987,0.07272382,0.0695716,0.0072378065,0.04475594,-0.012808743,-0.038949437,-0.065591566,-0.04324117,-0.057648297,-0.07504694,-0.037124407,-0.12388414,-0.006896109,0.08967759,0.0063483967,0.054150056,0.013100961,0.046714474,0.08602228,-0.0103257885,-0.108103774,-0.03941159,-0.015532018,-0.016202316,0.15590262,-0.0048777405,0.031141812,-0.03810646,0.05167896,0.052965537,-0.036640797,-0.053868044,0.16756861,-0.0854249,-0.023676973,-0.004194492,0.004567541,-0.0118390415,0.062927224,-0.044752363,0.048636764,-0.018101132,0.010825439,-0.028114628,-2.5215027e-34,0.065855846,0.03150044,0.06642692,0.011634687,0.031284418,0.025102342,-0.11507304,-0.008001895,-0.02304365,0.010951138,0.044249453,-0.09235609,0.028521826,-0.03202276,0.0004903765,0.02103013,-0.035567787,-0.06674544,-0.034396987,-0.027251959,-0.05172719,0.100394174,-0.05907726,-0.039655335,0.021504305,0.02539608,0.030612279,0.04909466,0.0006270962,0.022841409,0.010508374,-0.012027813,-0.035678346,-0.016238183,0.030846616,0.05143005,-0.07075227,-0.0014814145,0.035908714,0.046195347,0.085097075,0.007615634,-0.036409717,-0.046585463,0.038250253,-0.081863806,0.043137193,0.011791467,-0.028191816,0.064828195,0.009249218,-0.032718606,0.034685083,0.039968625,-0.026423354,-0.02738464,0.008175856,-0.028371207,0.004602505,0.08319578,0.07512332,0.0028444645,-0.07867054,0.08843902,-0.046215456,-0.04867902,-0.108286284,-0.043482248,-0.041553658,0.032274183,-0.055157144,-0.018681008,0.0033504197,0.007507696,-0.017350866,-0.030678872,0.032755733,0.010341694,0.002087553,-0.0662901,0.00022171282,-0.017338926,-0.030566463,-0.029258639,-0.07175306,0.016839607,-0.083127744,-0.050393198,-0.04324842,-0.0074022873,0.049565565,-0.071305096,-0.024888407,-0.0016697558,0.013541704,-2.9909769e-33,0.051041365,-0.0399541,0.031648166,-0.10339649,-0.011913856,0.10206962,0.13491035,-0.15370384,-0.031073743,-0.10217968,0.0035406577,0.047656324,-0.0026859012,-0.02070824,0.054061044,0.052034818,-0.018075379,0.09396955,0.016218046,0.01849022,0.0049271467,0.14765066,-0.0058569093,0.07399164,0.07831786,0.021599846,-0.0067174486,0.081754535,0.09754878,0.06279889,-0.021840546,-0.052676007,-0.014761477,-0.004137673,-0.030061286,-0.0022682145,-0.049445625,0.018864352,-0.033118717,0.110821374,-0.031653192,0.012144408,-0.0014971795,0.050701976,0.101570085,0.06524043,-0.01808974,-0.021690607,-0.0064680395,0.0007699313,0.047825623,-0.06101273,-0.049231812,-0.0010947394,0.010284353,0.059810173,-0.006894029,-0.019576984,0.04733723,-0.034799587,-0.07596944,0.033641707,0.038933396,-0.045661263,0.03848598,-0.0032636647,0.026873073,0.025360202,0.06621165,-0.0583792,-0.016948791,0.12013596,0.03666586,0.012299187,-0.012980857,-0.027275387,-0.06305396,0.007141639,-0.014404917,-0.07930899,-0.03283126,0.030746393,-0.012555205,-0.0063626547,0.012504667,-0.021650022,0.028842334,9.250368e-05,-0.011696442,0.067980364,-0.013583679,0.0026165813,-0.037227992,0.046649676,0.047895588,-3.9290946e-08,0.07814784,-0.09712397,-0.013412316,-0.012238763,-0.013905689,0.015160444,0.015221582,-0.03586066,0.05384703,-0.036909495,-0.017416947,0.15418208,0.07680678,0.039004114,-0.044012234,0.008206493,-0.050950136,0.04119978,-0.057904936,-0.015314341,-0.10496004,-0.058334153,-0.080786765,0.083051145,0.02334873,-0.025933862,-0.00527761,0.038791854,-0.01750551,-0.0029042244,0.05624872,0.036790024,-0.005188875,0.01836466,-0.040502224,0.025678476,-0.04009939,0.020428047,-0.0031435464,0.008538732,0.05365839,0.029849699,-0.045956343,0.02920821,0.0119973775,0.00054504676,-0.04267262,-0.009415283,-0.020416161,0.079299726,-0.012413372,-0.0064740395,-0.029875388,-0.08334236,-0.021492053,-0.010610013,-0.038317423,-0.010626426,0.014646448,-0.031394992,0.052874453,0.061490834,0.11803021,-0.066026695 +5.5.1.7,"Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts on 2-chloro-cis,cis-muconate. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase).",384,1.0,-0.010779739,-0.0035278061,-0.00481768,0.01294063,0.1224697,-0.043283284,0.043125432,0.040423416,0.054859072,-0.067501605,0.019264128,-0.03496699,0.08576264,0.015465702,-0.014627963,0.07874652,0.0013635571,0.089710005,-0.05086445,-0.030771613,0.05776136,0.003409025,0.021194454,-0.0067605223,-0.022556892,0.005839253,0.0011875834,-0.019553645,0.010370019,-0.0146428365,0.025004335,0.040220603,0.027722623,-0.07270676,0.05755553,0.028593857,0.008873592,-0.03648384,0.0001224049,0.0348344,0.0033247205,0.03955104,0.032353073,0.0148795275,0.00888744,-0.039899647,0.022926094,-0.036879066,-0.04102607,-0.004613933,-0.011970573,-0.023351053,-0.07916189,0.016617868,-0.04705341,0.022926476,-0.095050044,0.07479206,-0.022006102,0.0090573225,0.07168302,0.027693534,-0.010660689,0.01672329,-0.038273312,0.035482686,9.102443e-05,-0.056172606,-0.029993877,-0.007254145,0.0072187595,-0.051980417,-0.0634663,0.050994914,0.052255332,0.012890174,0.069211565,-0.05621748,-0.018842058,0.04107982,-0.050333165,0.01811119,0.14463946,-0.019360298,0.07257111,0.05492457,0.0548871,0.012887077,-0.038063068,-0.037178375,0.03284074,0.0074078436,0.007401951,-0.015699346,0.0060009207,0.06478936,-0.09115055,0.021125361,0.03442139,0.0053173285,0.008722097,-0.009282247,-0.12511653,-0.02496787,0.03484422,-0.008158893,0.060141955,0.07624948,-0.09291696,0.026983883,0.012134745,-0.0745914,0.0018445031,-0.028836867,-0.02388832,0.07741257,0.06785505,-0.029874912,-0.0058898395,0.017840037,0.044449966,0.00056695257,-0.017618695,-0.012615027,-0.041483153,0.123460434,0.016401006,5.016278e-33,-0.027271984,-0.002773191,0.11045956,0.07056068,-0.023218255,0.029585727,-0.041142594,-0.08040954,-0.028439458,-0.06470269,-0.01194747,-0.083994895,0.013590032,-0.024240246,-0.047259092,-0.07474226,-0.028436879,-0.007890835,0.07604894,0.0039947215,0.04042997,0.09812353,-0.041645262,0.09643978,-0.03762216,0.05655425,0.043692674,-0.048245657,0.1455121,-0.0048265406,-0.05458771,-0.042123333,-0.09687377,-0.026130917,-0.019112242,0.114396095,-0.030823795,-0.010596461,0.03493122,0.07193248,-0.032114383,-0.003048942,0.0028199235,-0.033150103,0.13648012,-0.04403502,-0.05849566,0.04298748,-0.016684016,-0.0039509456,-0.053872347,0.0148259485,-0.06570703,0.050743934,-0.040921245,0.02920118,-0.00050431123,0.027380675,0.031442627,0.02892573,-0.061762277,0.0072820853,-0.08345786,0.02948097,0.09724465,0.015595975,-0.07311432,-0.055557713,-0.08707599,0.032941572,-0.01630705,-0.11659789,0.05953819,0.0461893,0.07377801,-0.047075808,-0.07368432,-0.041474815,0.043596596,0.03773209,-0.036459383,0.026508879,0.0017980776,-0.020618934,-0.044812776,-0.044136934,-0.004455033,0.01106362,0.058175344,0.07156216,0.05106492,-0.049336955,-0.048437588,0.07796996,-0.06612712,-3.517111e-33,0.04072399,-0.049189303,0.11080155,0.0682945,-0.019821757,-0.028674696,-0.060392484,-0.16482593,0.029154973,0.04827709,0.110185355,-0.09882312,-0.058192745,-0.0045789606,-0.05173444,-0.058340926,0.052025434,0.08353533,-0.0040198616,0.10803133,0.044758514,0.013189267,0.056803327,0.047682058,0.020825235,0.04119904,0.036562536,0.030920684,0.08257747,0.008329414,-0.07195189,-0.04114199,-0.031429768,-0.062102955,-0.030009946,0.034342933,-0.05442701,-0.006750937,-0.029480085,0.04282983,-0.110443205,-0.06481278,0.012459758,0.021159334,-0.010429913,0.025077358,-0.06209082,0.041924376,0.0544217,-0.046615005,-0.015987609,-0.0059134765,-0.0869394,-0.028177576,-0.033419024,-0.021987814,-0.0014738828,0.057764575,0.04870051,0.04635499,0.060870677,0.06118402,-0.0013174515,-0.039572958,0.09868732,0.04326474,-0.033362456,0.098354444,0.03353074,-0.024562772,-0.02903568,0.030131422,0.06463896,-0.06619479,-0.013730351,-0.054732867,-0.11692058,-0.021770695,0.029146085,-0.02984328,-0.036317308,-0.029487025,0.018010108,0.025172481,-0.011752496,-0.09358707,0.0076272436,0.061713308,0.023468079,0.03610518,-0.0334727,-0.056260254,0.019003008,0.10861607,0.052156772,-4.4800256e-08,-0.028032571,-0.06338318,-0.01988021,-0.08411079,-0.07771289,-0.030270161,-0.040901694,-0.03472704,0.07945927,-0.009854254,0.03299049,0.016453564,-0.005594862,0.009213177,0.04487896,0.065773115,0.028043244,-0.02030995,0.037225787,-0.029964762,-0.050342787,-0.02854554,-0.10111652,0.00914822,-0.038859524,0.0061449404,0.06738649,0.08459752,0.026860973,0.0509282,0.0089285085,-0.039494887,0.038193934,-0.019859282,-0.017733965,-0.011835712,-0.040962134,-0.02389993,-0.009857206,-0.019193435,-0.017308004,0.010659849,-0.060163837,0.034033477,0.026880177,-0.07732308,0.010423861,0.03586565,-0.05361838,-0.032210764,-0.027575275,-0.074101366,-0.0061139637,0.015018487,-0.02162234,0.021007722,0.06258519,-0.016998634,0.0008037115,-0.03871708,-0.10181365,-0.019987756,0.13958913,-0.013956487 +5.5.1.8,Requires Mg2+. The enzyme from Salvia officinalis (sage) can also use (3R)-linalyl diphosphate or more slowly neryl diphosphate in vitro [3]. The reaction proceeds via isomeration of geranyl diphosphate to (3R)-linalyl diphosphate. The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (+)-bornyl diphosphate [3]. cf. EC 5.5.1.22 [(-)-bornyl diphosphate synthase].,384,0.99999994,-0.061016165,-0.040093955,-0.02214649,0.027809346,0.09091395,0.010620269,-0.02409165,0.009333596,-2.557721e-06,0.020679923,0.016684966,0.032100447,-0.016947493,-0.027776401,-0.011275999,0.052069336,0.00093363784,0.02080192,-0.008268702,0.016314317,0.11034061,-0.0125904,-0.0019526272,-0.038692407,0.11402104,-0.027924083,0.054484718,0.020292662,0.009230865,-0.05853817,0.071668044,-0.0030090818,0.048153363,-0.15248261,0.0030307532,0.05646958,-0.06603076,-0.032344364,0.02085935,0.028200323,0.044767343,-0.07600636,-0.041351058,0.019166606,-0.00021235124,-0.11936238,0.05357775,0.0032666132,0.100144885,-0.0026925465,-0.11226583,-0.09975654,-0.020628793,-0.019110186,-0.007148487,-0.02206943,-0.090465926,-0.0011609391,0.0015789766,-0.03126172,-0.01754847,0.013255401,-0.051361833,-0.097185984,0.0068496615,-0.0034419114,0.056778,-0.10762377,0.05075021,-0.07279573,-0.087080054,-0.02637697,-0.027988117,0.058206454,-0.048242807,0.032977473,-0.02226786,0.018684909,0.025858067,-0.026476769,0.02673021,0.05762454,-0.035078775,0.026635054,0.03890915,0.035282537,0.023657782,0.056774795,0.04875066,-0.041523494,0.011457479,0.0012302169,-0.03599588,-0.03863154,-0.060231946,0.036050506,-0.026703974,0.01861876,-0.0111154,0.0005365867,0.052967858,0.06804943,-0.06193534,-0.054669917,-0.03407484,0.09703131,-0.098940566,0.02309474,-0.033737242,-0.043406993,0.008518331,-0.002876925,0.0017957182,-0.011561524,-0.010635334,0.10848328,0.01904031,-0.04511652,-0.08370867,-0.026107334,0.050789572,-0.009695512,0.009667243,0.03927424,-0.029226687,0.049511198,-0.04379893,6.93248e-33,0.012051456,0.05145983,0.010856298,0.03248754,-0.06941678,0.00422137,-0.0664635,0.04456337,-0.010892444,-0.032916073,-0.022429498,-0.12053917,0.058087442,-0.022409892,0.0008202785,-0.043296516,0.09872446,-0.020096652,0.11622321,0.016530395,-0.09596591,0.051672056,-0.021561902,-0.036839485,-0.030614655,0.08566389,0.035521206,-0.04116553,0.097270474,-0.0120264,0.12977529,-0.05429708,-0.055727426,0.01938173,0.037532255,-0.06975523,-0.04366225,-0.070620045,0.018031968,0.03227551,-0.08175094,0.06454951,-0.0037175927,0.045634992,0.054692205,-0.07847503,-0.049019933,0.019544402,0.1023048,0.0019961214,0.030524999,0.035398193,0.09338075,0.077051066,-0.063204885,-0.012854488,-0.0075759795,0.010586561,0.009385738,-0.024071617,-0.031533636,-0.01342875,-0.044916417,-0.013955164,0.010839375,0.014692347,-0.08820824,0.03353796,0.03089544,0.10940558,0.034615945,0.033554252,-0.06868916,0.050978605,-0.06413452,-0.030904295,-0.038976137,0.063694365,0.05513728,-0.0243322,0.04576019,0.062487144,0.009160183,0.05111414,-0.05163949,-0.047660664,-0.07124659,-0.00313013,0.0021323953,0.041355457,0.05910041,-0.014622716,-0.07277155,-0.016964357,-0.024455227,-5.1208655e-33,0.12008424,-0.036090877,-0.03273789,-0.012049648,-0.080843955,0.037105225,0.06044793,-0.010428861,-0.040770467,0.016173825,0.027918262,-0.0364951,0.024986548,-0.07589002,0.0094596455,0.0014679008,-0.024034485,0.15340231,-0.042115334,0.0008999504,-0.01216303,0.06489044,0.06831386,0.020056853,0.02788119,0.022480534,0.01752666,0.009061291,0.030326257,0.08908445,0.058461566,0.055287357,-0.08107993,-0.1082345,-0.028152328,0.025310684,0.0019020708,0.029302688,0.006072331,0.04707246,0.0006369162,0.052266333,0.08067775,0.01787159,0.06375572,0.053607468,-0.030756064,0.050229553,-0.06461867,-0.113477804,0.018322118,-0.009131003,-0.013582456,-0.002510284,0.03860174,-0.014582238,0.027625462,-0.04851343,0.059030596,-0.108831294,0.0013202624,0.0026749093,-0.01744867,-0.04193906,0.044021513,0.09563911,0.053824656,0.065033495,-0.046968356,0.0030254861,0.030968362,-0.0075525753,0.056964416,0.026349489,-0.030098848,0.08921144,-0.011690481,0.026194576,0.068005495,-0.057720248,0.015692372,-0.027357211,-0.03101687,-0.075660475,-0.03572102,-0.06938493,0.006998834,0.044619385,0.014996662,-0.010842346,-0.036469743,0.0068595763,-0.0290977,0.050684538,0.16853225,-4.3770147e-08,0.026443234,-0.08179906,0.0072525064,-0.006596364,-0.0051694154,0.049292754,-0.011000406,0.0036465994,0.044385787,0.040920053,-0.06405777,0.038366828,0.05539204,0.0005172251,0.005670653,0.025802484,0.08237611,0.09989987,-0.01713255,-0.03557294,0.00682305,-0.024595952,-0.0433892,0.053466626,0.024240267,-0.15757346,0.03089563,0.06567098,0.04057478,-0.04445439,0.030835401,-0.01038804,0.030594053,-0.032079764,-0.0018887152,0.06423442,-0.06563248,0.0010819569,0.05084944,-0.054023854,-0.068772525,-0.051412243,-0.041041687,-0.0186603,0.015933497,-0.05006851,-0.009762517,0.009898915,-0.056395013,-0.027948434,0.029840328,-0.06245503,-0.007213197,-0.0603442,-0.08208923,-0.021244798,-0.012327562,-0.05787437,0.019964313,-0.08998822,0.01380517,0.053600673,0.042417265,-0.00523643 +5.5.1.9,"Opens the cyclopropane ring of a number of related 4alpha-methyl-9beta-19-cyclosterols, but not those with a 4beta-methyl group, with formation of an 8(9) double bond. Involved in the synthesis of plant sterols.",384,1.0,-0.034261808,0.023393475,-0.12508346,-0.00717812,-0.038485717,0.023911212,-0.062096164,0.014287408,0.079538554,-0.06520645,0.06062891,0.017855207,-0.05763221,-0.09185279,-0.008294244,0.007863775,-0.07715765,0.06913572,0.019318037,-0.006867633,0.04130444,0.0122512765,0.019681329,-0.019004924,-0.0074245003,0.027418008,-0.04880434,0.085481554,-0.010240994,-0.050959826,-0.0015152509,0.04261056,0.0044035227,0.0068080104,0.009932038,0.118497536,-0.04469958,0.0046553104,-0.008678861,0.053035963,0.057226513,-0.035374645,0.05085798,-0.026207276,-0.04284832,-0.010283898,-0.009485952,0.04122596,-0.010930092,-0.072386205,0.07584766,-0.06689854,0.007474037,0.022362668,-0.0068232757,0.055875905,-0.08160059,0.041383617,-0.0063570687,-0.029540082,0.096549824,0.07900998,-0.104188055,0.011618082,-0.14713046,0.029387986,-0.029618852,-0.029156268,0.020791665,0.058461078,-0.007519292,0.009777112,-0.06342775,0.020059157,-0.04179769,0.0811646,-0.014564234,-0.08191437,-0.011560349,-0.0481582,0.106441304,0.007689539,0.04456251,0.025421454,0.06870363,0.043530207,0.036326535,0.014962303,-0.006570833,0.018623682,0.061744332,0.0269037,0.016840266,0.025557484,-0.060980126,0.07549338,0.083453834,-0.0379264,-0.021331951,0.017687976,0.09146724,-0.0061348313,-0.06721856,-0.0061295256,0.028566327,0.0033849168,0.003986006,0.068964735,-0.060366552,-0.053678397,-0.046959918,-0.023401087,0.033206582,-0.065005615,-0.067083195,0.03394035,-0.020909645,-0.0033641579,-0.046955228,-0.030156687,-0.017880507,0.03246911,-0.028532261,-0.00022244947,-0.021823604,0.057866607,-0.11868236,8.582373e-35,0.063665584,0.07662201,0.07257442,0.015170217,-0.0050761015,-0.035856143,-0.02051861,0.007665076,-0.009651229,-0.051536676,-0.037975647,-0.10031514,0.0065300497,-0.0067090737,-0.036100376,-0.024460748,0.005108632,0.09491642,0.07801377,-0.112888895,-0.07086466,0.12770781,-0.0069815004,-0.021665111,-0.007802918,-0.0373712,0.032269794,-0.07455126,0.0908344,-0.0010901018,-0.068227306,0.011667555,-0.031962626,-0.015526115,0.055377934,0.05383602,0.0068593854,-0.07929316,-0.012427567,0.026714547,-0.0047856513,-0.015082436,0.004262111,-0.015721988,0.077747695,0.008114115,-0.109713875,0.06326502,0.016594999,0.056316484,0.026937727,0.017907182,-0.0067019444,0.11549905,-0.08558328,-0.013767981,-0.019563967,0.021109607,-0.029323725,0.045463685,0.009041284,0.059347916,-0.06917468,-0.016383922,-0.0036691371,0.012828364,-0.035606723,-0.07519901,-0.12341308,0.04727697,0.0057711196,-0.08514655,-0.024685329,0.031252485,0.102473445,0.08256114,-0.017107336,-0.011880202,0.037682906,0.019677728,-0.024219183,-0.0081921425,-0.019266997,-0.08530922,-0.04494347,0.008764561,-0.01604603,-0.0116798235,0.039159365,0.057957746,-0.007949373,-0.05450278,-0.028170083,0.003415959,0.004896264,-1.691013e-33,0.028477948,-0.0005283655,0.040329333,-0.04072498,0.017827367,-0.005417859,-0.045043834,-0.16643408,-0.011351139,-0.025194317,0.0683843,0.013478814,0.02779038,-0.008106635,-0.028889885,-0.08778192,0.013643223,0.10631636,0.0029915601,0.051708337,-0.025522763,0.036645398,0.036190078,0.16114555,0.016169647,-0.0441313,0.07746358,0.016109226,0.05197448,0.026851982,0.048602972,-0.05584876,0.0014107294,0.039519485,-0.07048381,0.026339725,-0.03182966,-0.022060923,0.03343167,0.016724305,-0.061517667,-0.087095,-0.025765827,0.0018721725,0.08252601,-0.054535132,-0.0067371493,0.07475113,0.021639349,-0.012110536,-0.004963825,-0.0034528647,-0.050754283,0.026592532,0.047093626,-0.0033384715,0.01878791,-0.013617716,0.076292455,-0.05552501,0.015497672,0.04660695,-0.022424966,-0.057161022,0.07310244,0.058692466,0.082697876,-0.026814597,-0.010617777,-0.020774782,0.03418465,0.015572134,-0.0078060925,0.029715355,-0.013374409,-0.012324377,0.017870698,-0.046263255,-0.058044348,-0.056644708,-0.045345135,-0.031931467,0.11900048,-0.05866704,-0.0789125,-0.050395332,0.08304667,0.054296315,0.017529579,0.025178462,0.00772352,0.067649685,0.08403646,0.07466343,0.07509797,-3.3426183e-08,0.063654095,-0.02931745,-0.0031400127,-0.10464052,-0.12123254,-0.041556593,0.056897502,-0.024106584,0.047531467,-0.051021323,-0.05330912,0.07150335,0.042045966,-0.03197142,0.032519832,-0.033669073,-0.059599902,0.017959636,-0.0044808644,-0.067795485,-0.064894654,0.0058979252,-0.024203226,-0.015700899,0.0038309721,-0.066299304,0.054377697,0.019105785,0.05359684,0.041562326,0.15333167,0.00017524557,0.011855186,0.025829343,0.037495334,0.047883637,-0.018677453,-0.014097275,0.024003854,0.015259851,-0.045643657,-0.057974577,-0.011521202,0.027910376,-0.05942824,-0.037772346,0.030630907,0.10903445,0.004278598,0.023532119,-0.04678341,0.0030874603,-0.0035658113,-0.088098906,-0.036136147,-0.04339437,-0.003869568,-0.0022574055,-0.010357988,-0.013438397,-0.04491146,-0.023051815,0.11261497,0.022846894 +5.5.1.10,Both rings of pinene are cleaved in the reaction.,384,0.99999994,-0.046713363,-0.07060693,-0.02499643,0.047017947,0.023677351,0.008187091,0.001380866,0.03751788,0.11233465,-0.036341168,-0.0030387486,0.026614206,-0.024799488,0.01868444,-0.071219556,0.03264375,-0.1335364,0.04083234,0.018374799,0.10374159,0.0642864,0.043725356,-0.03781421,0.057783313,0.032792855,0.025530301,0.015925903,0.007102594,0.006202893,-0.036968853,0.05765867,0.027458528,-0.04682161,0.038415425,-0.087171294,0.013208574,-0.064980805,-0.028006542,0.051640842,0.04697949,0.006028956,0.02077086,0.03036866,-0.100665934,0.003594376,0.032613263,-0.031484373,0.009360134,0.0020461364,-0.00058256485,0.0207362,-0.06477344,-0.0882427,-0.0018609549,0.07248132,0.058097046,-0.045186132,-0.092490114,0.044509113,-0.0022821652,0.03054323,-0.006596539,-0.07197125,0.003298294,0.012909077,-0.038901825,-0.016566439,0.0110215265,0.035377175,-0.049339443,0.058258265,0.021456582,-0.08813529,-0.060868427,0.0401426,0.012803949,-0.02919316,-0.014472721,-0.008754063,-0.010487928,-0.07186442,-0.037939962,-0.01569355,0.04892048,0.02934039,0.08000636,0.010414899,0.034538835,-0.039282143,-0.0072560543,0.034420557,0.06818003,-0.0637365,0.03613993,-0.014421669,0.0016000329,0.041211475,0.012820597,-0.0333432,-0.018157737,-0.063238256,-0.0043190466,-0.025092756,-0.15685838,-0.065200865,0.02458453,0.014483182,0.045360915,0.0016558293,-0.027783852,-0.015945373,-0.010116576,0.037085358,0.056432888,-0.043484017,0.117189154,0.02463702,0.011693493,-0.043332934,0.007205475,-0.027167622,0.025474025,-0.04167714,0.052220967,-0.094089255,-0.023265418,-0.011316681,-1.3071702e-33,0.048439797,0.04168058,-0.0037152462,0.017257746,-0.043884743,-0.023849968,-0.10304069,-0.092641674,0.018807817,-0.068591006,-0.06119029,-0.02075403,-0.011593688,-0.049591884,-0.03734351,-0.04500184,0.021131799,0.015191329,-0.0030474358,-0.02617497,-0.090095215,0.13859653,-0.10473196,0.07587569,0.009084743,-0.0026752616,0.03849398,-0.031220997,0.0029387537,-0.0314949,0.082606226,0.09396168,-0.06896309,0.05915104,0.06783231,0.038878843,-0.036983706,0.0019466823,-0.05157434,0.017494202,0.08945529,0.024642516,-0.040582318,0.099370845,0.046445068,-0.0803169,-0.04179046,0.12514877,0.06019403,0.045455016,0.070548035,0.086418495,0.03903745,0.011796559,-0.048207436,0.0092468,0.028881626,0.014571226,0.03313002,0.038878758,-0.001408555,0.02721554,-0.0116039375,-0.021243278,-0.05753615,0.078718655,-0.12949571,-0.017668566,-0.054748837,-0.0017754458,-0.010768837,-0.03416817,0.04502947,0.032750294,-0.025106613,0.010002269,-0.034417048,-0.0060190186,0.03581524,0.05165077,-0.065379344,0.02820956,-0.02414114,-0.03626272,-0.089501984,-0.020939548,0.03610456,-0.011847388,0.062286187,0.1334592,0.06348996,-0.025424838,-0.014030447,-0.050197516,0.043519575,1.278086e-34,-0.016853351,-0.14570059,-0.010297828,0.08245142,-0.012664217,0.025793316,-0.04389075,-0.12864679,0.024703093,-0.040864952,0.07687847,-0.0026317076,-0.058295485,0.005066769,0.034589123,-0.011345709,0.07046172,0.100141905,-0.005874394,-0.019353358,0.030109942,0.0593105,-0.031518754,0.013372294,-0.0074997977,0.05166495,0.0049533155,-0.013098443,0.022154909,0.02387285,0.11372387,-0.08894736,-0.0721617,0.0060876156,-0.027835254,0.07511215,0.0684078,-0.028935876,-0.0076983827,-0.04758863,-0.05676195,-0.079261094,0.0056037847,0.13559036,0.06066689,-0.032296035,0.048212286,-0.060117334,-0.052462555,-0.0022423642,0.01926661,0.03309488,-0.014451067,-0.03362542,-0.0067518977,0.021488931,0.02707635,-0.07074038,0.113065176,-0.084696665,0.012515698,-0.017074589,0.011505637,-0.093405314,0.015161344,-0.005535294,-0.009129612,0.056314204,0.07376821,-0.044016603,0.0695487,0.09997818,0.029723443,-0.002046167,0.005795603,-0.028956102,0.0057891817,-0.07727988,-0.06345364,-0.055781852,-0.034965307,0.04316339,0.013618286,-0.015960967,-0.02439561,-0.003239827,0.057245843,0.06779491,-0.040052947,-0.033195905,-0.017554648,0.007421548,0.048195016,0.08175595,0.09378999,-1.8700304e-08,-0.01620848,0.0046586213,-0.03568351,0.017608901,-0.05832994,-0.0029067732,0.037097316,0.025543116,-0.0552386,-0.12219996,-0.047987267,0.10071112,0.028008988,-0.018581213,0.08146537,-0.011872626,-0.06635799,-0.061255407,-0.029991679,-0.03715797,-0.0069984496,-0.013929847,0.000800027,0.02799933,-0.08859628,-0.06848985,0.049774494,0.09230407,-0.020631414,-0.03688291,0.09112632,-0.014177091,-0.04973745,-0.01840833,0.052135374,0.01946029,0.025197305,0.05841381,0.05135778,0.013071032,-0.011755373,-0.039916098,-0.048045244,0.046814464,-0.022063095,-0.024143942,0.004613375,-0.0109150475,0.0115672415,0.04984904,0.04873183,0.029355653,0.023429124,0.04759472,-0.05844987,0.010557058,0.023944624,-0.00880852,0.030765275,-0.013967826,-0.097556986,-0.056035083,0.070359774,0.02985476 +5.5.1.11,"Requires Mn2+. The product of cycloisomerization of dichloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylene-3-chlorobut-2-en-4-olide. Also acts, in the reverse direction, on cis,cis-muconate and its monochloro-derivatives, but with lower affinity. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.7 (chloromuconate cycloisomerase).",384,1.0,-0.028162278,-0.0009519199,-0.018876933,0.015668212,0.105099,-0.033617094,0.035179168,0.05639851,0.04683738,-0.030846996,0.008404208,-0.04171865,0.08146832,-0.00537164,-0.018315647,0.10941721,0.015459168,0.09826087,-0.057849336,-0.0011950951,0.044114638,-0.0010963228,-0.014942982,-0.009000366,-0.028017879,0.04665626,0.011504948,-0.020023787,0.005010505,-0.0057370346,0.03086038,0.045043517,0.04666658,-0.06704456,0.05599671,0.039581418,0.0018765891,-0.04566254,0.014150884,0.04072295,0.0019333068,0.06755676,0.033693418,0.024805376,-0.0017592643,-0.023427038,0.029380435,-0.02269962,-0.027980652,-0.012825375,-0.012517699,-0.009084078,-0.08637802,0.038029425,-0.06676128,0.01877751,-0.09473892,0.05602301,-0.031247556,0.0030624901,0.048321076,0.015786892,0.013475164,0.017539242,-0.050782125,0.007209115,-0.022670629,-0.056876693,-0.010829621,0.0030498744,0.0100965705,-0.040616427,-0.03957726,0.043449793,0.027309233,0.009321551,0.09673252,-0.036116052,-0.01601617,0.025872096,-0.04499333,0.019486794,0.16807073,-0.0029523664,0.06587423,0.042964794,0.05822952,-0.0039658714,-0.030466896,-0.032828283,0.047469355,0.008911163,-0.0015190074,-0.012210286,-0.012268334,0.059725843,-0.087534264,0.020310089,0.019920858,0.009780043,0.005847803,0.0016165016,-0.11539558,-0.04499598,0.02185733,-0.0065928875,0.055111628,0.086652525,-0.084348045,0.03098292,0.007092797,-0.059538208,-0.0019249554,-0.019089792,-0.0018218562,0.06154635,0.0897901,-0.015541688,0.005044126,0.032337666,0.04659848,-0.010806155,0.004697034,-0.005267674,-0.0626322,0.12953001,0.008554621,4.0419406e-33,-0.03329552,-0.010969559,0.09493327,0.058047842,-0.037418336,0.034099087,-0.038656306,-0.08135143,-0.03258504,-0.06803989,-0.006801449,-0.072871715,0.013821896,-0.016557967,-0.054246772,-0.07399699,-0.034814846,0.0028914826,0.07639402,0.00019469493,0.046964884,0.08319592,-0.03852188,0.0749634,-0.029089952,0.07973438,0.0363791,-0.0556076,0.13322297,-0.0062224804,-0.05650104,-0.027105564,-0.090300515,-0.016000275,-0.024281595,0.12973405,-0.020018278,-0.0059818784,0.020589523,0.0679269,-0.051102266,-0.026157975,-0.022859754,-0.052704215,0.14541169,-0.04178398,-0.06718615,0.032063007,-0.024024153,-0.016397653,-0.06739767,0.00025880226,-0.059979193,0.06432659,-0.05256291,0.016212486,-0.007694742,0.01881809,0.03429265,0.02710594,-0.073243864,0.03727277,-0.08337971,0.021096965,0.085050106,-0.008959833,-0.073931426,-0.056530546,-0.08650822,0.048730183,-0.009176314,-0.113881886,0.044776678,0.059089288,0.06147217,-0.055558182,-0.06755136,-0.02817391,0.042716693,0.05498548,-0.017326368,0.012481842,-0.0022750183,-0.028948722,-0.04315765,-0.039064135,-0.008585654,-0.02522543,0.042534493,0.06039743,0.053517424,-0.033098068,-0.06880612,0.073818,-0.060089413,-3.15685e-33,0.054043114,-0.079657264,0.08558522,0.079871505,-0.023763431,-0.024360342,-0.07090039,-0.15699606,0.015410325,0.028366165,0.103387564,-0.10383714,-0.08582955,-0.0071090176,-0.053181365,-0.048186798,0.062430687,0.09772459,-0.012957214,0.077239186,0.055742007,0.01763367,0.039652802,0.02830973,0.035051353,0.0046933675,0.036409255,0.038807996,0.08151293,0.00859552,-0.08928132,-0.024673354,-0.031598102,-0.069009386,-0.02833519,0.032786053,-0.111533545,-0.009086469,0.0027763045,0.04075017,-0.09699462,-0.049295075,0.03912491,0.011720617,-0.016991062,0.024591275,-0.06734403,0.031671375,0.07198875,-0.04307823,-0.014703465,-0.02361185,-0.07270201,-0.014797872,-0.026620988,-0.008567579,-0.0039958656,0.04689312,0.031531643,0.064442694,0.059725974,0.045816943,-0.014416098,-0.04547855,0.10429582,0.076749936,-0.012062276,0.092112266,0.041290175,-0.027434131,-0.0041336883,0.018791143,0.070165865,-0.052209746,-0.0038374322,-0.046591945,-0.12303286,-0.007886913,0.011036293,-0.033405997,-0.028523063,-0.033474702,0.028314492,0.035726905,-0.029295634,-0.06926895,-0.002477702,0.062392544,0.006259747,0.039624326,-0.04312919,-0.07088736,0.0098586595,0.10184666,0.056056157,-4.524399e-08,-0.047858335,-0.07842054,-0.02738915,-0.075866625,-0.06586225,-0.005154173,-0.047765944,-0.044375993,0.07141576,-0.0091548115,0.028204272,0.017910196,-0.0013261848,0.033966642,0.05789174,0.08910189,0.04556903,-0.032879595,0.0528821,-0.005730151,-0.05185711,-0.027164035,-0.085457206,0.00818566,-0.03422155,0.0019481832,0.054703772,0.06474775,0.038282897,0.043586317,0.0014072149,-0.034501825,0.04179858,0.0024842126,-0.015019755,0.0064157643,-0.053489745,-0.04893038,-0.023869416,-0.0106223,-0.012222202,0.038611405,-0.046901047,0.039347216,0.024493808,-0.075411715,0.01799528,0.05425206,-0.07249316,-0.047106445,-0.034279544,-0.05588666,0.0025053483,0.0077207405,-0.018388186,0.048581682,0.051992677,-0.020316364,-0.013826465,-0.018447787,-0.10929151,-0.027624764,0.121429786,-0.00991835 +5.5.1.12,"In some plants, such as Salvia miltiorrhiza, this enzyme is monofunctional. In other plants this activity is often a part of a bifunctional enzyme. For example, in Selaginella moellendorffii this activity is catalysed by a bifunctional enzyme that also catalyses EC 4.2.3.131, miltiradiene synthase, while in the tree Abies grandis (grand fir) it is catalysed by a bifunctional enzyme that also catalyses EC 4.2.3.18, abietadiene synthase.",384,1.0,0.018201424,-0.03587491,-0.02159819,0.025601724,0.05567573,0.048211113,-0.05459408,0.072249815,0.051930305,-0.024429051,-0.012141301,-0.040668122,-0.05050525,-0.023493465,-0.028116463,0.05889693,-0.102234885,0.04102757,-0.04079727,-0.044186763,0.14923571,-0.049952377,-0.048061002,0.0039204955,0.00086974975,-0.042719703,-0.02497199,-0.018624626,-0.007650145,-0.09600208,0.05974127,0.042820614,0.10917403,-0.03375102,0.007418876,0.07421759,-3.774455e-05,-0.13756235,0.017262476,0.02195258,0.055032033,-0.010688364,-0.06870761,-0.07918042,-0.016442418,-0.040105853,0.05897462,-0.051315293,0.0019515501,-0.046892475,-0.015481627,-0.07984617,-0.05301572,-0.008780925,0.03749525,-0.02113166,0.0034265723,-0.014184389,0.016387165,0.03324077,0.031729102,0.037743323,0.0037452097,-0.043312453,0.055361867,-0.047446333,-0.03345733,-0.09453641,0.0011120368,-0.091895856,-0.023820458,-0.065650016,-0.09456462,0.006330765,0.028590862,0.031867627,-0.0071564405,0.007883927,0.024041925,-0.009367794,-0.022114573,0.02776297,-0.014852471,-0.062600434,0.0828615,0.034980435,0.0031330588,-0.010198583,0.07256147,-0.03439424,-0.0097553115,-0.030001838,-0.026703099,-0.0025861177,-0.022903172,0.08525223,0.009589616,-0.024421917,0.03007604,-0.036195014,-0.039622124,0.053445652,-0.030037394,-0.079687156,-0.04888158,0.045924958,0.01347188,0.07833288,0.015275915,-0.043275896,-0.036463402,-0.048646882,0.086535156,0.039659623,-0.04035449,0.042261135,0.014169868,-0.059264176,-0.0038707936,-0.0069338745,0.04941099,-0.019353963,0.022817183,0.06998607,0.019301828,0.076515615,-0.094737045,4.5173363e-33,0.071887754,-0.033100132,-0.033412617,-0.021078827,-0.040076032,0.012871842,-0.057588276,0.08155961,-0.07297833,-0.07351123,-0.09388802,-0.027853219,0.041115895,0.03804529,0.03188081,-0.043673478,0.061796475,-0.044153754,0.055276282,0.029820828,-0.03141998,0.024685068,-0.055647362,0.027704863,0.012659547,0.023899782,0.04616393,-0.03166818,0.040238116,-0.009220794,-0.0076714503,-0.08100205,-0.09781338,0.025094982,0.014794006,-0.016083224,-0.020998517,-0.0038730786,-0.077004544,0.038278926,-0.090908,0.01434362,0.003484369,-0.03557554,0.091593534,-0.039046723,-0.08476169,0.08657055,0.10289117,0.026008101,-0.0020563572,0.03631141,0.103076175,0.0053712116,-0.02299096,0.10222356,0.004443385,-0.009482178,0.030686824,0.089107886,-0.021584561,0.04479934,-0.020870127,-0.051312685,0.01276281,0.10075763,-0.026597084,0.0008459437,0.05362754,0.08115299,-0.030638104,0.0075653214,0.005758515,0.063996956,0.030488014,-0.029905405,-0.034375947,-0.007086754,0.036130242,0.02143216,-0.003480214,0.04873797,0.047065075,0.04801764,-0.03858203,-0.06336295,-0.08159386,-0.00957076,-0.035217255,0.074585676,0.047324214,-0.0019286069,-0.034637444,0.026701083,0.032274447,-4.9629743e-33,0.09549074,-0.05142685,0.0062288796,-0.096913606,-0.10388054,0.10886972,-0.068105325,-0.07199664,-0.037446618,0.038178176,0.023617584,-0.03867865,0.065705836,-0.0921593,-0.06086253,0.015160156,0.014415947,0.10730643,-0.010960645,0.02460096,-0.04957783,0.1324561,0.027844237,-0.00804784,0.040193424,-0.03625119,0.0087923575,0.042487413,0.019432882,0.040026974,-0.0059938966,-0.02024008,-0.06629523,-0.10365807,-0.04131986,0.030494504,-0.015185469,-0.0037658713,0.051071275,-0.0055428674,-0.022842979,0.029088672,0.052031897,0.0488633,0.093297854,0.033862516,-0.092460796,0.0119047575,-0.032137427,0.019648906,-0.024715126,-0.013668732,0.010068005,-0.03438354,-0.0065123504,-0.022082802,0.037669968,-9.296072e-05,-0.029977005,-0.06609327,-0.018522652,-0.03466769,0.054612953,0.013238429,-0.008844529,0.03762145,-0.040918034,-0.012756756,0.03244256,0.020233506,0.10035309,-0.008218372,0.0006755966,0.077949345,-0.02572217,0.052175544,-0.024215747,-0.06178049,-0.021420214,-0.0002040232,0.044543356,0.017406775,0.013952081,-0.08386526,-0.09438201,-0.10274492,0.031692974,0.08191841,0.012974595,-0.043851696,-0.023063803,-0.016840287,-0.02527513,0.029133836,0.10628118,-4.5085628e-08,-0.02848645,-0.016098816,-0.030532468,-0.07995401,-0.01859791,-0.015309726,-0.019767188,0.0060899034,0.014049155,-0.012869666,-0.059122484,0.04824001,-0.012147572,-0.023215013,0.046538725,0.008662538,0.093622364,0.033389635,-0.0019678562,0.05454685,-0.0057267286,0.022368459,-0.13249512,0.08941688,-0.027937884,-0.13001488,0.039316352,0.054156367,0.0045244577,0.02352642,0.05287287,0.067574345,0.06671495,-0.00079875556,-0.050224755,0.012848704,-0.0006180607,-0.011443792,-0.017176116,-0.01144259,0.06799648,-0.10141401,0.002392059,-0.04131274,0.009851061,0.03142253,0.019451138,-0.012398886,0.046275146,0.02222515,0.09050041,-0.040054873,0.029605119,-0.027813744,-0.0828763,0.0091026,0.015100007,-0.11799911,0.069526486,-0.07677797,0.033469602,0.027069429,0.1795413,-0.04035876 +5.5.1.13,Part of a bifunctional enzyme involved in the biosynthesis of kaurene. See also EC 4.2.3.19 (ent-kaurene synthase),384,1.0,-0.08277556,0.019291155,-0.0101236645,0.0005777391,0.038328197,0.06288539,-0.055110052,0.014691914,0.04388426,-0.028791713,0.022717386,-0.10583153,-0.026094023,-0.06492794,-0.060002357,0.022324491,-0.13780856,-0.0049094376,-0.025754297,-0.05248888,0.072883755,0.047132723,-0.008993799,-0.011974335,0.05539065,-0.01734359,0.028501555,-0.110454954,-0.0008473366,-0.048894133,-0.04841152,-0.013684563,0.00048947195,-0.03441662,0.0032022386,0.0572892,-0.05392952,-0.004116072,0.079312734,0.009016792,0.066826046,-0.028774919,-0.11384809,-0.03071013,0.008219886,0.044115495,-0.0073485076,-0.006900134,-0.072595015,0.061222196,-0.014805488,-0.06494719,-0.026689673,0.0036070845,0.092238344,-0.012629455,-0.079885915,0.031034902,-0.010888554,0.07470777,0.16175416,0.01973105,-0.028059036,-0.010877616,0.02720696,-0.13538806,0.045759156,0.016565643,-0.007820648,-0.08139505,0.00060096104,-0.07914646,-0.039547548,0.035775643,0.047154594,0.030820562,0.0057959915,-0.026546968,0.0011107883,0.0045695254,0.09920557,-0.01915906,0.00470157,-0.032239646,0.03287686,-0.004197356,0.031800732,-0.0043111867,-0.013852106,0.026440192,-0.015384711,-0.057393312,-0.016800381,-0.01184282,0.09707651,0.025584683,-0.01744978,0.06312027,0.033900227,-0.06527587,0.008625836,0.083302714,0.034905884,-0.052293137,-0.04683305,-0.080988616,0.011909856,0.04840138,-0.0031848333,-0.0177018,-0.024036987,-0.063801005,0.08192439,-0.028290838,0.0038542172,0.075975776,0.004422858,-0.05327228,0.009467523,0.032571428,0.04704004,0.047653496,0.00078996614,0.11240577,-0.035711437,0.0033970228,-0.042053036,-6.0022693e-34,0.06272926,0.044279523,0.01778132,-0.002283114,-0.025189662,-0.018172607,-0.0658139,0.0033194234,-0.1260283,-0.06267054,-0.06454157,-0.1032562,0.045345105,0.02417548,-0.045335717,-0.01113947,-0.009917934,-0.016572533,0.07654176,-0.027746694,-0.0043399995,0.0367992,-0.09654714,0.06389801,-0.030692061,-0.033217944,0.0150884325,-0.041921098,0.014780237,-0.042844284,0.0075962055,-0.024614004,-0.06254613,0.022906233,-0.003695984,-0.051641744,-0.0073979,-0.033501443,-0.06838667,0.06107982,0.012564711,-0.01647293,0.04577977,-0.01970664,-0.027824208,-0.015069655,-0.07468542,0.044851784,0.06897043,0.05864335,0.045744963,0.037212364,0.12728855,-0.010955243,-0.04994865,0.07605835,-1.92174e-05,-0.07590657,-0.01989141,-0.004142087,0.004025098,0.052786086,0.0040153386,0.010486566,-0.010346752,0.002988705,-0.071332835,-0.019688893,-0.025922004,0.05615546,-0.10459697,-0.06765773,0.061097372,-0.059643287,0.05267287,0.018572802,-0.1476854,0.017303493,-0.105635345,0.025386106,-0.030773027,0.046135806,-0.008187898,0.008433082,-0.017267527,-0.07318357,-0.015524306,-0.03268745,0.06623907,0.0586955,-0.013650436,-0.04822167,-0.11620237,0.05489942,-0.00085666386,-1.8246831e-33,0.12895626,-0.05455926,0.0405801,-0.008893898,-0.026646614,0.07071379,0.024461543,-0.03309042,0.03384931,0.05453112,0.08736118,-0.027464576,0.053717133,-0.040389348,0.023351947,0.037087105,-0.0060433894,0.038653642,0.05254858,0.008268421,0.014846563,0.039331585,-0.022111023,0.041572202,-0.0096015325,0.059932772,0.013065889,-0.006870199,0.031522535,0.030619739,-0.024810638,-0.12509666,-0.03890019,0.011911022,-0.09667904,0.06496677,0.057264637,0.012068489,-0.015215585,-0.005008814,0.028945463,0.06913651,0.031694084,0.07157647,0.08312978,0.0016849033,0.06694713,-0.0010267285,-0.059670538,-0.08947681,0.0738626,0.07016217,0.0040996224,-0.019795984,0.01556385,0.055317525,-0.030101173,0.069222294,0.016161613,-0.0006746192,0.014695306,-0.07182839,0.08305605,-0.06495164,-0.006799918,-0.0076201153,-0.07971302,0.1171928,0.041987624,-0.049416065,0.037800275,0.014946335,0.013848783,0.06743213,0.01246329,-0.05536632,-0.03250624,-0.035837926,0.043535303,-0.033139057,-0.007961512,-0.036731828,0.011964929,-0.022058195,-0.03761936,-0.057040267,0.023506213,0.060527395,0.043995544,-0.06355601,-0.05855164,0.0124425525,-0.07872274,0.099000715,0.02507956,-2.7365152e-08,0.11655026,-0.081912704,-0.0128015485,-0.04973975,-0.021138173,-0.04470558,0.034630444,0.054046284,0.024461024,-0.004213713,-0.059074286,0.0009173931,0.028861526,-0.05014072,0.09348114,0.0073138895,-0.07441258,0.0822063,-0.0030509736,-0.023884742,-0.01605007,0.028877636,-0.13194764,-0.0070857476,0.024379198,-0.036486704,-0.00062005245,0.040839996,-0.005624411,0.008261404,0.021541836,0.013185895,-0.013031928,-0.045651685,-0.014083357,0.02307878,-0.041715216,-0.043475468,-0.007960192,0.044118516,-0.028484853,-0.059304908,-0.023176365,0.032612,-0.024098268,0.029078437,0.021068841,0.0168327,0.017320331,-0.010964512,-0.025823426,0.04118684,0.019286772,-0.0004993356,-0.056754407,0.026665911,0.0020238624,-0.120055124,0.03819435,-0.058604494,-0.020122308,0.06037088,0.1842986,0.0013601959 +5.99.1.2,"These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.1.2.2 DNA topoisomerase (ATP-hydrolysing).",384,0.99999994,-0.05400994,-0.029472442,-0.034558818,-0.016857423,0.024101363,-0.0057764603,-0.05495218,0.06933897,-0.04500765,-0.060456228,0.088407606,0.05622434,-0.051566157,-0.018047167,-0.054846536,0.033358607,-0.10988222,0.06423037,-0.035432365,-0.064338975,0.07544,0.033529997,-0.008509883,-0.03734435,0.052112013,0.06605603,-0.035783876,0.04326282,0.043704323,-0.043201882,-0.0007616513,-0.008809602,-0.051565915,-0.016774695,0.105336845,0.103938945,-0.013670066,0.08046765,0.040577557,-0.026151624,0.11251145,-0.011674711,0.01139668,0.027085477,-0.07170606,0.0042189094,-0.012979014,0.031293314,-0.035771165,0.00867715,-0.049416643,-0.014866314,-0.07737013,-0.04060406,0.023881756,0.14789452,-0.010145064,-0.027970035,-0.012748216,0.008527272,0.08515758,-0.013002456,-0.021674609,0.04641925,0.12175111,-0.082035296,0.12406033,0.062698565,-0.0129296575,-0.0065906676,-0.030759845,-0.040017974,-0.0447017,-0.011364282,0.015400426,-0.042376895,-0.08041523,-0.05711604,0.008859429,0.072918296,-0.05138848,-0.06787863,0.053213365,0.0121318875,-0.02494075,-0.054057427,0.08323625,-0.0064575993,-0.057674818,0.05071543,-0.017559228,-0.07152574,-0.024322243,-0.046546094,-0.05202327,0.044637967,-0.008851453,0.057209533,0.03378047,-0.03649306,0.045743376,-0.08904562,-0.043461643,-0.07675857,0.004508983,-0.00049388176,-0.0036360614,0.032576144,0.06029516,0.002920844,-0.047179982,-0.061022323,0.050680976,-0.051799588,-0.0860852,0.068569265,-0.019234305,0.01411454,0.0552501,0.0151852425,0.008966375,-0.02563534,0.10518703,-0.008101954,-0.040202867,0.023456257,-0.015133671,2.2130502e-34,0.010515348,-0.0071915598,0.03171334,0.031312183,-0.07195792,-0.026225671,-0.09733772,-0.0099469405,-0.098000504,0.07562337,0.010485159,0.03769692,0.0353395,-0.029874042,-0.020917619,-0.048444886,0.0043927254,0.00036253364,-0.026573373,-0.032704476,-0.0068664183,0.08254525,-0.03244886,-0.005822187,-0.012004354,-0.0018226797,-0.011305502,-0.0080379825,0.104030475,-0.0026927057,-0.004348784,-0.0050652036,-0.060672946,0.08835955,0.05496802,0.084170505,0.04120348,-0.03488928,0.027255243,0.02466429,-0.051489364,-0.0049658343,0.0512416,-0.10076533,0.08007321,0.0026873478,0.01625107,0.03781155,-0.034135167,-0.022871347,0.008742668,-0.08574006,0.07056627,0.008727868,-0.049919803,0.0025762988,-0.004366149,0.021666428,0.0066269217,0.08542908,-0.019927302,-0.021582419,-0.029508125,-0.05032938,0.050446734,0.035265666,-0.036862228,-0.049647566,0.019010758,0.08740345,-0.11908187,0.04397497,0.014610748,0.0029433996,0.0361442,0.018625751,-0.07920172,-0.035865895,-0.053132165,0.021587087,-0.036595114,0.029461324,0.014310928,-0.02625111,-0.011537285,-0.017450254,-0.047568344,-0.038673297,0.052268606,0.054875303,0.08158672,-0.03289547,0.03741964,-0.005547791,0.038986083,-1.319181e-33,0.06825213,-0.07420377,0.024825487,0.034423944,0.013720096,0.024461063,0.0127296485,0.0032534928,-0.034926046,-0.012151391,0.048174,-0.017209243,-0.0324785,-0.09851203,-0.037415482,-0.06559545,0.047745675,0.057201814,0.011218982,0.020383399,0.011563949,0.02806837,0.0046890294,0.0230534,0.035664454,0.031779252,-0.010969041,0.052705776,0.09312597,0.04562423,-0.084984094,-0.039347094,-0.022281043,0.035278622,-0.09813948,0.106696725,-0.0062785516,0.06538296,-0.011372511,-0.0041122925,-0.03278104,0.059047207,-0.032161083,0.043330766,0.0494548,0.024714565,-0.12806596,0.039109074,-0.083976805,-0.06352799,0.040080633,0.052869778,-0.070669174,-0.055053703,-2.6067475e-05,0.026364833,-0.04496926,-0.05304177,-0.008676642,-0.007015793,0.00978695,-0.0956829,0.015478197,-0.031112004,0.04543056,0.011468438,-0.060828116,0.006874826,-0.12510507,0.019116132,0.010356365,-0.0023425992,0.022439664,0.019702641,0.085600965,-0.03955614,-0.013890463,-0.07815105,0.00531035,-0.07501588,-0.021196498,0.011644204,-0.056416433,-0.05459006,0.12108451,-0.04354391,0.05639064,0.070353046,0.0062484024,-0.030903101,-0.027982797,-0.008438816,-0.027419602,0.05304247,0.004337063,-3.871918e-08,0.03257794,-0.08773232,0.033320587,-0.03635987,-0.012050108,0.08425743,0.051440727,0.054753434,0.14355473,-0.0066780336,-0.009225521,0.10259266,-0.029852277,0.012595588,0.04028956,0.047434356,-0.08646984,0.040357813,-0.025087086,-0.018344147,-0.10261551,-0.0008360511,-0.11479181,0.044194147,-0.015798358,-0.027873633,0.0756873,0.058314074,0.018474149,-0.069121934,-0.03564453,-0.0040342757,0.036572307,-0.008081894,-0.07318677,0.05849754,-0.06611442,0.035452764,-0.033314694,-0.0033165982,0.08818779,-0.020064292,-0.09473862,0.030896554,0.07828324,-0.04317036,0.08450569,0.053611893,0.0069867964,0.023962006,0.0012799042,0.008173691,0.012102424,-0.08980884,-0.013461204,0.014611675,0.049242612,0.0340168,-0.0322291,0.02303607,0.0036039646,-0.031287447,0.13278781,-0.016186848 +5.99.1.3,"The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.99.1.2 DNA topoisomerase).",384,1.0,-0.058079563,-0.048244517,-0.047435984,-0.022985058,0.020790804,-0.034558713,-0.08192157,0.11865644,-0.005533753,0.019410199,0.09707888,0.038624674,-0.040133704,0.035326358,-0.046276167,0.040818587,-0.07235602,0.0066886386,0.01001119,-0.070721,0.123340786,-0.03129509,0.000714321,-0.031460393,-0.017661985,0.093208216,-0.016857356,-0.0056452355,-0.016314005,-0.08571968,-0.018818036,0.0076610073,-0.08229976,-0.024532732,0.08435843,0.07226943,-0.038008515,0.12963317,0.027258955,-0.023380022,0.09041062,-0.00650042,-0.03147807,0.034693655,-0.058399692,0.008277606,-0.03871191,0.058309153,0.02814917,0.043016125,-0.058181435,0.008273117,-0.017928975,-0.030251196,0.04790588,0.11551019,-0.03538769,-0.0065298104,-0.039094962,0.024522997,0.06543715,-0.050586503,-0.030777203,-0.03898976,0.14659122,-0.06198001,0.043659694,-0.031172046,-0.04067471,0.030156065,0.04675261,-0.068383336,0.006973491,-0.029278085,0.0464592,0.03309833,-0.08063057,-0.0641823,0.03847604,0.09365585,-0.0088969935,-0.051561866,0.090885326,0.04595565,0.025646985,-0.016374426,0.16194972,0.0038128535,-0.04014488,0.08795133,-0.047615673,-0.06989228,-0.022262093,-0.06570016,-0.07077352,0.06637271,-0.046212003,0.03454226,-0.034128685,-0.040478688,0.04500273,-0.073951624,0.010985286,-0.080999725,-0.008260492,-0.007623796,0.014463727,0.025366245,0.06906719,0.037864335,-0.01721992,0.00047931238,0.03414577,-0.0618922,-0.08547946,0.0643386,0.026682274,0.038754534,-0.08838956,-0.031418096,0.01993739,-0.017579678,0.027348666,0.027512,-0.0168656,0.08706699,-0.05698785,7.899392e-34,0.014663507,0.02817568,0.047169134,-0.024016814,-0.06499461,-0.06850372,-0.09384961,0.0463252,-0.08626646,0.052549653,0.046640504,0.008327977,0.05406351,0.006451035,-0.055888854,-0.05893708,-0.0035169774,-0.033891674,0.01274398,-0.033482466,0.022323286,0.0420568,-0.014520593,-0.032702968,0.01452651,0.0040318803,-0.0034352872,0.01172101,0.081941366,-0.0041321726,-0.003489956,-0.059828337,-0.04304147,0.087353945,0.049830385,0.055667903,-0.026507758,-0.053366374,0.0022820556,0.036372162,-0.098254904,0.024497299,0.048778597,-0.12756167,0.035867486,-0.022627627,0.03908545,0.024883082,-0.039233387,-0.0040309126,0.046001665,-0.067876816,0.032507516,0.0400744,-0.004951801,0.041014507,0.0038667729,0.027357223,-0.0003924362,0.021790937,0.030995443,-0.06756402,-0.061154444,-0.05893757,0.014333449,-0.007034869,-0.045053516,-0.042778403,0.05896566,0.051769502,-0.07596966,0.033348113,0.04892574,0.01492892,0.014859377,0.045340113,-0.017792357,-0.029212056,0.043236114,0.017117226,-0.0010739575,-0.014460828,0.046493877,-0.052919924,-0.039497692,-0.01370192,-0.025514053,-0.06543012,0.010868303,0.048171304,0.07196848,-0.069498725,-0.011329502,0.052170772,0.0020555523,-1.4891591e-33,0.011585683,-0.07541154,0.012487944,-0.037140504,-0.01744209,0.038301148,-0.0014351888,-0.03464446,-0.033010006,-0.017449275,0.071887106,-0.026869502,-0.02431159,-0.020783529,0.04433587,-0.022605447,0.057061117,0.056928884,0.03545227,-0.010442519,-0.036591157,0.09467905,-0.016998623,0.0697121,0.075292744,0.024009183,0.011332435,0.08945922,0.084254235,0.050030313,-0.083852686,0.0433021,0.03860512,0.057032514,-0.04564406,0.07712993,-0.05433026,0.0032567456,-0.0023606971,-0.03215645,-0.041115634,0.07102573,0.022558952,0.082194865,0.025018565,0.0015615752,-0.07213825,0.1028665,-0.0015806684,-0.12294012,-0.017911026,0.008162056,-0.051044695,-0.0074857743,0.020907888,0.020511543,0.01736858,-0.046125136,0.039527558,-0.0002719888,0.0044858567,-0.058107894,-0.009012209,-0.04134984,0.021254914,0.057018552,-0.073705405,-0.00236511,-0.09554332,0.008241049,0.031907212,0.07221405,0.011502231,-0.008010693,0.044404533,-0.023679702,-0.04637069,-0.052993495,-0.019208997,-0.07495487,-0.035684444,0.04235593,-0.08323486,-0.03505727,0.066106156,-0.076430954,0.045946065,0.08670499,-0.0361263,0.019467156,-0.032803383,0.04436091,-0.06057674,0.09130372,0.058512166,-3.496722e-08,0.0067929607,-0.06731586,0.07088211,-0.020574763,0.011250807,0.03280767,0.070026994,0.033823043,0.13725133,-0.022013012,-0.039470207,0.107474014,-0.043457568,-0.02213418,0.04808598,0.06792642,-0.079698086,0.020601986,-0.020349244,-0.016063545,-0.09538339,-0.033096757,-0.1274605,0.016437292,-0.052188817,0.010873783,0.07480104,0.027972136,-0.008856855,-0.050131038,-0.025237063,-0.0057163397,0.023617765,-0.005575284,-0.09246548,0.03269014,-0.045195714,0.039439496,0.014519634,-0.0029897427,0.08635621,-0.024077272,-0.08852548,0.031871412,-0.013500051,-0.002034261,0.002866538,0.001111673,-0.0023051065,0.010710785,0.0092257485,-0.022581676,0.038872633,-0.05669707,-0.05100166,0.017831907,0.028607853,-0.0022437093,-0.0353634,0.02938908,0.008182977,-0.041530706,0.15382916,-0.013978545 +6.1.1.10,"In those organisms producing N-formylmethionyl-tRNAfMet for translation initiation, this enzyme also recognizes the initiator tRNAfMet and catalyses the formation of L-methionyl-tRNAfMet, the substrate for EC 2.1.2.9, methionyl-tRNA formyltransferase.",384,1.0,-0.06897314,-0.07904615,-0.082534894,-0.022199329,0.0017162826,0.015461841,-0.044215765,0.043565378,0.05684526,-0.032952707,0.045201283,-0.13987938,-0.089417376,0.01503055,-0.03514655,0.02653493,-0.13172866,-0.0058957576,0.0034920697,-0.043091323,0.041379236,0.101828545,-0.024874112,-0.007465168,0.038165886,-0.04592117,0.03251968,-0.018289616,0.10343393,-0.0699256,-0.02724744,0.0041151214,0.043995436,-0.028131537,0.07112433,0.10125452,-0.052718587,-0.06854421,0.04729336,0.014405437,0.035590433,-0.02282952,0.022260772,-0.06252114,0.0036780357,-0.058773804,0.035555337,0.07428161,-0.009698962,-0.02758811,-0.057907194,-0.051355038,-0.022568492,0.018020106,0.00614181,0.062439006,-0.020067649,-0.009743162,-0.011215803,-0.005214599,0.023255594,0.045803223,0.0124018695,-0.04445769,-0.00033677285,-0.014149599,0.06096848,-0.05151658,0.07062407,-0.009909223,-0.10373098,-0.04392573,-0.018499924,0.08460002,-0.02262209,0.024243409,0.0038887786,-0.05202282,0.010074118,-0.0051834635,0.014123969,0.014806677,0.035839267,-0.022097427,-0.007553742,-0.019751193,0.004665402,0.0556746,0.029309873,0.09793902,-0.017093685,-0.04204322,0.028558506,-0.008523148,-0.08283654,0.07843199,0.047762897,0.13689885,0.08565465,-0.0346172,0.0059324163,0.058061823,-0.08332784,-0.035919566,-0.05049836,-0.074201524,0.059714153,0.0032148955,0.0033537399,-0.057547256,0.06916972,-0.059569124,0.042260066,0.030502547,-0.008590823,0.0810566,-0.020066578,-0.08514134,0.07160066,-0.009306075,0.008837908,-0.017286453,0.030749712,0.022614693,-0.049984194,0.051735096,-0.069548875,3.0096744e-33,0.06659185,0.07225087,0.004913195,0.057727817,-0.0055688224,-0.04255218,-0.1273087,-0.008117047,-0.06634354,-0.07002065,-0.06504425,-0.04231494,-0.018793378,-0.00067328615,-0.012453154,-0.049067188,-0.039042436,0.050688434,-0.010064412,0.01924384,0.032409746,0.020685216,-0.02173095,-0.016278146,0.020958895,0.02636123,-0.017881177,-0.00035881758,0.05305993,0.0063748984,-0.049032535,-0.10255057,-0.053122018,0.049573,0.048184253,-0.03391428,0.010569342,-0.059180096,-0.02624981,-0.0023924229,0.08072313,0.00089201675,-0.0025408315,-0.031128706,0.045259867,0.024194952,-0.0531485,0.04676851,0.05374799,0.022460995,0.01573279,-0.045779232,0.04722097,0.0001071646,-0.0068260147,0.04921723,-0.058097858,-0.08122203,0.0652977,0.09719975,-0.041317496,0.0044943155,-0.025230285,0.116823524,0.003419794,-0.023139928,-0.02619629,-0.07444495,0.011274881,0.03222331,-0.03353279,-0.049354777,0.028186351,0.039311457,0.105833694,-0.048225928,-0.049608108,-0.011301738,-0.018518643,0.024708137,-0.033014167,-0.0024612336,-0.040552977,-0.07028738,-0.012818956,0.00733966,-0.0040263776,-0.04516066,-0.0056137787,0.071165144,-0.0062941816,-0.033585384,-0.082618564,0.010025653,0.026574064,-4.5132305e-33,0.01965828,-0.07442262,-0.02612736,-0.079709746,-0.11631057,0.03989485,0.04259714,-0.053458124,0.07248406,-0.014726129,0.09175547,-0.0035349568,0.013168484,-0.06696648,0.024758428,-0.14131665,0.06654902,0.014004866,0.062762424,-0.020348206,0.043391347,-0.045664337,-0.08273584,0.028739884,0.06343404,-0.012551902,-0.01718353,0.1335838,0.004540084,0.05896157,-0.024947679,0.027593035,0.046339292,0.051476415,-0.07224707,0.034873072,-9.11709e-05,0.028735267,0.011749051,-0.024510473,0.021827938,0.047817674,-0.009980279,0.04893899,-0.021350969,0.09707829,-0.05136173,-0.017592087,-0.011018345,-0.04546549,0.08319343,-0.010852175,0.008682517,-0.03472328,-0.017812321,0.066943616,-0.026708895,0.013649071,0.060846265,-0.036395658,-0.0059315586,-0.047929235,-0.0060755103,0.018796649,0.084944725,0.020296043,-0.008818221,0.09126289,0.031346187,-0.015402579,0.069856696,8.28841e-05,0.01248083,0.025633825,-0.033543758,-0.040551364,-0.08718419,-0.04056421,0.070063405,-0.07316317,-0.015303003,-0.023510408,0.012657906,-0.08295464,0.015263053,-0.09119675,0.025594525,0.13649918,0.026571224,0.14481491,-0.04059927,0.012411246,-0.052354123,-0.0015093473,-0.008194355,-4.1841638e-08,-0.04726644,-0.0747318,0.021791534,-0.02439885,0.050581556,0.045510657,-0.025649067,0.01026413,0.061395194,-0.012303482,-0.06332975,0.001091055,0.022730485,0.015216707,0.037674513,0.056781724,-0.016832791,0.06630064,-0.019154968,0.027909137,-0.062266253,0.039062824,-0.12154997,-0.007930035,0.0041342527,-0.0074378117,-0.005529526,0.1264799,0.0284216,-0.06484929,0.009127342,0.019318383,0.018816162,0.0021136377,-0.11825582,0.024991045,-0.058173135,-0.1061096,-0.028374976,0.058429338,0.031952977,0.015847657,-0.07425914,-0.03383105,-0.05322326,0.004745776,-0.06583685,0.05979081,-0.020148275,0.001995706,0.055975858,-0.05191398,-0.0032854818,-0.033398267,-0.05741866,-0.010788185,0.00833242,-0.032124337,-0.0059496015,0.04214791,0.0033852796,0.08341017,0.15317543,-0.011456456 +6.1.1.11,"This enzyme also recognizes tRNASec, the special tRNA for selenocysteine, and catalyses the formation of L-seryl-tRNASec, the substrate for EC 2.9.1.1, L-seryl-tRNASec selenium transferase.",384,0.99999994,-0.021713203,-0.08249215,-0.058998503,-0.036311805,0.086376615,-0.011500641,-0.0576856,0.025025023,-0.013618205,-0.11325867,0.048436873,-0.05949841,-0.073663786,-0.012710261,-0.053927463,0.010038643,-0.049724523,-0.024941383,0.0026267904,-0.037440404,0.024374675,0.031070529,-0.012588072,0.0054781963,0.017479096,-0.037026737,0.0700119,-0.066318095,-0.044318277,-0.08820627,-0.030046705,-0.09788579,0.05908965,-0.017189771,0.018549949,0.03491101,-0.097491674,-0.053264283,0.01106603,-0.001038379,0.0301737,-0.064282045,-0.014454814,-0.07949166,-0.08394726,-0.0903807,0.053089034,0.036862314,-0.031031653,0.07513861,0.011825649,-0.045490656,-0.099542424,0.02257321,-0.05860795,0.058875654,-0.0391581,0.00475753,-0.02951687,0.025809918,0.03140789,0.05709912,0.032677773,-0.021690115,0.04725138,-0.0779068,0.08599185,-0.06368939,0.001488851,-0.03574761,-0.049707167,-0.061241828,-0.021675723,0.077663906,0.030376395,0.055337343,-0.023737727,-0.013590578,0.046601553,0.024563955,-0.0044870013,-0.052151226,-0.02681424,0.052601404,0.021069199,0.017479729,-0.0013350437,0.06205947,0.025964132,0.032523904,0.0977473,-0.030749474,-0.0118079325,-0.02220992,-0.025770942,0.089391984,0.023121998,0.13039838,0.021088446,-0.036519304,-0.017045584,0.070589654,-0.018074859,-0.05883688,-0.050717685,-0.009115285,0.0332075,0.012956096,0.0062749116,-0.11979684,0.039349016,-0.032516636,0.03562339,1.7690996e-05,-0.010952936,0.08474477,0.02030599,-0.010889031,0.030654948,0.04251287,0.006300151,0.03099813,0.055428453,0.06105353,0.01601683,0.093879744,-0.12437688,-2.2488734e-34,0.024424337,0.04500501,0.028765645,-0.016157595,-0.038936842,-0.007977123,-0.12259421,0.06536895,-0.105069175,-0.07487487,-0.11563494,-0.08161527,0.084016904,-0.03086429,0.010814005,-0.05319061,-0.0029008798,0.010811079,0.08089899,-0.028892215,0.027875716,0.022242628,0.006365945,0.030570861,0.024672624,0.010362593,-0.005386243,0.051998433,0.08858428,0.012294991,-0.0132853845,-0.046928406,-0.07945634,-0.0065724007,0.09193364,0.042235848,-0.002153787,0.00034643448,-0.06188985,-0.0057705888,0.011574418,0.019755716,0.013026415,-0.03951184,-0.01615291,-0.094535165,-0.042179205,0.07560769,0.05008926,0.014080222,-0.0049034134,-0.11275817,0.06326195,-0.04665893,0.010793685,-0.009307953,-0.028795473,0.016207706,0.077218875,0.083287895,0.035442952,0.051949687,-0.03717447,0.050071668,-0.019917183,0.015426137,-0.07246117,-0.028346198,-0.012832617,0.03132947,-0.08015094,0.0075008487,0.06403099,-0.014066625,0.08082891,-0.04801286,-0.103287935,-0.028878175,0.022304352,0.007622815,0.0021420284,-0.060036987,0.01380947,-0.020694653,-0.014189424,-0.042265724,-0.03072619,0.018051052,-0.023371771,0.06455953,0.03751149,-0.012631763,-0.061277285,0.011825668,0.014092974,-1.2903857e-33,0.03926862,-0.11644925,0.015603018,-0.05272683,-0.0474785,0.02374443,0.06116962,-0.090665564,0.0074703796,-0.010250504,0.08783257,0.003406548,0.034493327,-0.09325045,0.043348916,-0.028584044,-0.0013099212,0.00016440803,0.03405335,-0.035338458,0.0422568,0.031272307,-0.0017020928,0.052164778,0.021686915,-0.045968328,0.012715644,0.102199204,0.03563645,0.05490972,-0.0741514,-0.008899171,0.027339542,0.09070064,-0.084554516,0.064858146,0.02439998,-0.0064123515,0.10534824,0.01621144,-0.005009536,0.022386631,-0.0023257758,0.09498175,0.031656608,0.06871058,-0.031411316,0.07149096,-0.04110269,-0.063862324,0.053505518,0.006901873,-0.011550694,-0.020844415,0.0473226,0.11200616,-0.027589373,0.010091786,-0.032939613,-0.014116188,-0.064869605,-0.011560767,-0.03447207,0.008825569,0.054957844,0.0038828615,-0.04159378,0.07093997,-0.02375941,-0.035343282,0.06422565,-0.011987166,-0.03927437,-0.012299051,-0.0021158534,-0.11022833,-0.026951743,0.043774385,0.0372246,-0.037890874,0.007474076,-0.027260145,0.07487908,-0.06635722,0.075023085,-0.046650343,-0.028778225,0.13704284,0.049927026,0.067836344,-0.034618516,0.005869665,-0.02348457,0.054231584,0.078854956,-2.9696725e-08,-0.0077181025,-0.06738025,0.027944412,-0.03212782,0.102401115,0.05453527,-0.0022913225,0.009937824,0.024113817,-0.008157449,-0.06832713,0.05995733,-0.024266819,0.001490145,0.0642565,0.029023841,-0.006590118,0.078584366,-0.0055569704,0.008465102,-0.027625376,-0.024295403,-0.10715948,0.012890909,0.0011148247,-0.034041543,-0.019788358,0.05181902,0.017668553,-0.054185566,0.011697772,-0.040653493,-0.0019929484,-0.0709637,-0.055356283,0.016410293,-0.023285748,-0.03316164,0.0028520373,0.096621126,0.02069734,0.019264167,-0.09116389,-0.041130535,-0.009772607,0.010768698,-0.008440612,0.04977925,-0.031443488,0.044238783,0.053652994,-0.07623583,0.016782539,0.004914007,-0.020322086,0.00044015085,-0.0045596412,-0.09731661,-0.020280823,0.0064942697,0.05036627,0.115953006,0.16578722,-0.03569336 +6.1.1.13,A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4'-phosphopantetheine cofactor of D-alanyl carrier protein during the activation of the alanine. Involved in the synthesis of teichoic acids.,384,0.99999994,-0.032476485,-0.06699852,-0.07876521,-0.052566063,0.0015758388,0.113948576,0.017575493,0.021147966,0.051522437,0.098071866,0.03584479,-0.028517218,-0.07163328,0.0030588452,0.038760196,0.017763954,-0.07534091,0.017408222,-0.057386316,-0.042374652,0.0012263904,0.06263019,-0.042871684,-0.0316906,0.04653851,0.08509346,0.05811601,0.009602596,0.05691919,-0.015505939,-0.015599188,-0.034866847,0.023295565,-0.03134733,0.009820128,0.0715334,-0.03414093,-0.06196567,0.010871948,-0.013302868,0.044504542,0.026663737,-0.014310834,0.00681459,-0.10170557,-0.029832423,-0.010875689,0.09526344,0.013669878,0.021670109,-0.003412274,-0.055053297,-0.020509638,0.005217169,-0.057243463,0.12123461,-0.041907404,0.042180706,-0.07079806,-0.016405292,0.014554739,0.043005053,0.015873004,-0.018789727,0.0147198755,0.06842322,0.047256216,-0.020953016,0.08780163,-0.03245159,-0.026800366,0.020906208,-0.022645121,0.009038354,0.034847416,-0.0099913245,0.023701651,-0.023579536,0.034393366,-0.06748246,0.015475431,-0.00078432064,0.01666456,0.023202183,-0.003638195,-0.02921228,0.006326086,-0.05296303,0.0572473,-0.018315213,0.049433824,-0.03039942,-0.00041204048,-0.049731843,-0.03339402,0.009761282,0.014224932,0.0040576947,0.01626974,0.0020561563,0.044688214,0.0642755,-0.14020805,-0.00011300769,-0.06347081,0.016550338,-0.065832354,0.050671563,-0.08252736,0.012866715,0.040740132,0.0028226967,0.09485951,0.0051249713,-0.07165961,0.037298203,-0.033135954,-0.06402363,0.0037663989,-0.06278601,0.044672437,0.017819865,0.055343915,0.11334362,-0.025379194,-0.046895515,-0.08933381,1.9743074e-33,0.13160713,0.0682687,0.071372546,0.013421628,-0.040097486,-0.034023017,-0.098758936,0.050484203,-0.012485447,-0.022733655,-0.102323666,-0.10577545,0.05112968,-0.046566695,0.0197925,-0.022497209,-0.029583152,0.09180817,0.08439495,0.068969145,-0.05840546,0.14896053,0.024371793,-0.003846383,-0.047979973,0.039323118,0.017588992,0.03898774,0.043065377,0.047112048,-0.07678168,-0.028099407,-0.047467686,-0.0027146002,-0.0061086896,0.007489222,-0.11757718,-0.0007426723,0.014223639,0.059019364,0.054561377,-0.012910654,-0.028584143,-0.06645825,-0.016236413,-0.084250554,0.024399107,0.034082614,0.019288093,-0.0018429615,0.0021922954,-0.044803403,0.0743927,-0.0075768335,-0.07471434,-0.02334584,-0.050866194,-0.012378135,0.0029462085,0.05066842,0.05860762,0.001849426,-0.010099869,0.06178507,-0.054520827,-0.013631823,-0.047737278,-0.07656595,-0.023919566,0.08206851,-0.033381652,-0.004355815,0.06906959,-0.005900947,-0.014071043,-0.017883135,-0.046239324,0.04209525,-0.03117551,-0.029222254,-0.0020758014,-0.01789054,-0.022668077,-0.011887731,-0.05931203,-0.04365109,0.054381397,0.00988009,-0.0115436595,0.014194035,-0.03979368,-0.03783766,0.023206895,0.040362023,0.07478158,-3.417263e-33,0.060854677,-0.074965395,0.004070932,-0.0417618,-0.038209956,0.015308791,0.02321168,0.025875553,-0.042039994,0.008442816,0.11078454,-0.010371951,-0.04994239,-0.09604997,-0.0046687066,-0.027068565,0.051523924,-0.004363683,0.020373672,-0.043912027,0.0013631844,-0.08005188,0.027037285,-0.014299266,0.041914098,-0.018738575,0.0066365595,0.021379411,-0.017740447,0.10258342,0.035136145,0.001618537,-0.046296556,-0.0020484005,-0.083983116,0.10870034,0.011039331,-0.008321468,0.027317964,0.038517367,0.0021146399,0.01575071,0.115747325,0.046619818,0.008582494,0.003685837,-0.0894519,-0.09232878,-0.029241936,-0.05301043,0.06590295,-0.039749965,0.010710044,-0.026363684,-0.016329324,0.14499173,-0.02322515,0.039284576,-0.028503979,0.010097269,-0.032072745,-0.052074715,-0.0023227464,-0.08563973,0.027451565,-0.03288329,-0.08309285,0.06480877,0.067897916,0.011191138,0.04072885,0.07902478,0.02378282,0.06293181,0.046064816,-0.0917799,-0.037728086,-0.048635527,-0.0002634449,-0.04058552,-0.064119056,-0.025989713,-0.03829801,-0.020405412,-0.05186264,-0.027246624,0.032652657,0.11873377,-0.03657467,0.058081046,-0.05450927,-0.0014854597,0.004428653,0.105067864,0.07341269,-3.6592144e-08,0.025378967,-0.06625161,-0.07616823,-0.01477886,-0.031982575,0.06206117,0.048765723,0.0015714463,-0.01506012,-0.02929449,-0.021068566,0.048549496,-0.009053182,0.04577869,0.0069702216,0.06701657,-0.12913305,-0.045275223,-0.04400121,-0.07859534,0.009274159,-0.0035616683,-0.07009771,-0.012073334,0.006313625,0.008677409,0.06321277,0.011078147,-0.029372532,0.07210768,0.019320883,-0.022542689,-0.053083204,-0.047029875,0.010170054,0.04213762,-0.011001573,-0.013087056,-0.024916882,0.024731671,-0.0014980964,0.07437476,-0.13441026,0.085552745,0.08817313,-0.010678138,-0.03540049,0.13715915,-0.10369636,0.014803567,-0.027052773,0.034310244,-0.021058137,-0.037789304,-0.070282824,-0.038771894,-0.021119751,-0.0816374,0.04558475,-0.015846346,0.028610121,0.016520603,0.12721132,-0.048681777 +6.1.1.23,"When this enzyme acts on tRNAAsp, it catalyses the same reaction as EC 6.1.1.12, aspartate---tRNA ligase. It has, however, diminished discrimination, so that it can also form aspartyl-tRNAAsn. This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon [1]. This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNAAsp (GUC anticodon) and tRNAAsn (GUU anticodon). The aspartyl-tRNAAsn is not used in protein synthesis until it is converted by EC 6.3.5.6, asparaginyl-tRNA synthase (glutamine-hydrolysing), into asparaginyl-tRNAAsn.",384,1.0,-0.106251,-0.11551766,-0.13019148,-0.008184735,-0.0144810565,-0.012166819,-0.040203895,0.039542254,0.015328304,0.004138689,0.05002248,-0.00904052,-0.057873387,0.028246343,-0.102681,-0.018222526,0.0008686814,-0.05128678,0.054586347,-0.023989825,0.04104945,0.055992384,-0.035242524,0.0075584664,0.039155923,-0.0038379247,0.052531775,-0.06716284,0.01878824,-0.05760501,-0.06393615,-0.054690126,0.066481,-0.022615112,0.017169733,0.053562485,-0.15451522,-0.066267654,0.09865094,-0.018639183,0.004219243,0.031256188,-0.017215546,-0.056666672,-0.0013744106,-0.032260604,0.036161624,0.04830524,0.008481913,0.064925864,0.06469386,-0.0059565534,-0.09846165,0.04584827,-0.046206713,0.08819642,-0.14634469,-0.01880416,-0.037240993,0.024513828,0.018603556,0.054100636,-0.030799028,-0.019227995,0.077268265,-0.04819946,0.08378527,0.005635652,0.034319554,0.012876106,0.0052773072,-0.0070602256,0.06255608,0.0561435,0.01772036,0.030035509,0.07091998,-0.01912938,0.026925107,0.032969825,0.008262096,-0.030684449,0.06151564,0.07027461,0.02871472,0.0062516695,0.005451375,0.05012979,0.06987295,0.076941356,0.06746401,-0.0073406086,-0.007329578,-0.048044384,0.020383144,0.037497025,0.012892531,0.078842945,0.023913233,-0.08212949,-0.035764437,0.023602318,-0.036544792,-0.038301747,0.02141817,-0.0063292747,-0.007496752,-0.0111930715,0.08373892,0.011332624,-0.0005452338,0.01916814,0.014354099,-0.007904603,-0.035720043,0.043599185,0.015377225,-0.032923877,-9.123035e-05,0.008260998,-0.03466872,0.027015364,0.039832216,0.10183116,-0.032975063,0.068725355,-0.08685133,1.7213374e-33,-0.030680599,-0.048063777,0.021452747,-0.03396666,0.031151062,0.022951657,-0.103706345,0.0017542868,-0.07176174,-0.048583608,-0.06278111,-0.07389927,0.042558506,0.0082686655,0.023716193,-0.032913987,-0.03802064,-0.015586443,-0.004443989,-0.03355398,0.00015839371,0.08729021,0.010886717,0.057356488,-0.006608064,0.036116555,-0.04616433,0.069465384,0.0545741,0.0008543542,-0.035863128,-0.07217704,-0.09869119,0.037452463,0.08097443,-0.0015235952,-0.004630203,-0.050580777,-0.041272905,0.033862527,0.023871558,0.002675121,-0.013801281,-0.012034654,-0.02475029,-0.06450333,-0.027219964,0.06490771,-0.008250199,0.016464958,0.02672977,-0.033519816,0.037597597,-0.022124533,-0.055310737,0.0070278333,-0.009997471,0.0074960557,0.10080697,0.08790745,0.0022223464,-0.012447049,0.019612143,0.007800434,-0.048251934,0.042320125,-0.079755716,-0.058652405,0.004186827,0.043757837,-0.08796798,-0.025859177,0.0009145679,0.013385726,0.06347714,-0.03745356,-0.025778808,0.056593258,-0.0134336185,-0.0028112854,-0.05004193,0.006073029,0.038176868,0.02454655,-0.032774936,-0.017347941,0.038900156,-0.056075685,0.03948273,0.093061745,0.02453019,-0.030604111,-0.089852326,0.037004843,0.035232347,-3.1114193e-33,0.05258402,-0.14457549,0.03296247,-0.04282587,-0.12498565,0.071562015,0.06441073,-0.11764208,0.0049842685,-0.10654201,0.09274467,0.05310053,-0.057142522,-0.031492744,0.022129726,0.01855128,0.0025523582,0.0562242,-0.012941393,-0.035820063,0.016252607,0.024406584,-0.028511476,0.0032180024,0.02511027,-0.032451224,-0.0076158266,0.04075191,0.015811393,0.09126581,-0.035195317,0.006401994,-0.038633972,0.02052829,-0.107860684,0.056864243,-0.00428107,0.001198403,0.043433253,-0.034049664,0.05125139,0.034489743,-0.0033300288,0.06799478,-0.00091224315,0.0782766,-0.026740804,-0.00085538934,-0.06419215,0.010430351,0.14083616,0.010526578,0.036367584,0.043836355,0.032993063,-0.008676903,-0.054822996,-0.0681693,0.008301806,-0.015114768,-0.0076792743,-0.06502434,0.008888268,-0.07206121,0.084134854,0.0361845,-0.018286843,0.06852573,0.035424236,-0.04223849,0.04037671,-0.031282183,-0.03048178,-0.00016439671,0.021276008,-0.08916213,-0.0016057217,0.0071618115,0.073155314,-0.09434803,-0.106354624,0.04145528,-0.0021785903,-0.037928484,0.03090819,-0.014239477,0.06782739,0.14492677,0.03691361,0.08973951,0.008036387,-0.005431465,0.011560817,0.017112866,0.0748274,-4.8051234e-08,-0.016530327,-0.059976038,0.01105742,-0.051525835,0.060839918,0.09408138,-0.044885732,-0.014165079,0.035298567,-0.05281204,-0.021757372,0.059823625,-0.033504535,0.003395077,-0.018374804,0.012700835,-0.07608752,0.05509608,-0.0004250757,-0.03428365,-0.11525767,0.0072671915,-0.15300511,0.007135919,0.02343091,-0.0035849044,-0.036761306,0.023113778,-0.038112182,-0.02082972,-0.04180706,0.0074277613,-0.005595095,-0.065754734,-0.031859916,0.018470505,0.04565125,-0.041760582,-0.013753048,0.058824982,0.016705764,0.03972412,-0.026226532,0.014559751,-0.08352226,0.013187486,0.045430027,0.041743085,-0.02444998,0.10060689,0.084183015,0.01585122,0.01700066,-0.02846251,-0.08681954,-0.032657877,-0.004042299,-0.13807231,-0.05769884,0.036629606,0.0076736896,-0.021271877,0.12204365,0.010501419 +6.1.1.24,"When this enzyme acts on tRNAGlu, it catalyses the same reaction as EC 6.1.1.17, glutamate---tRNA ligase. It has, however, diminished discrimination, so that it can also form glutamyl-tRNAGln. This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon [1]. This accounts for the ability of this enzyme in, for example, Bacillus subtilis, to recognize both tRNA1Gln (UUG anticodon) and tRNAGlu (UUC anticodon) but not tRNA2Gln (CUG anticodon). The ability of this enzyme to recognize both tRNAGlu and one of the tRNAGln isoacceptors derives from their sharing a major identity element, a hypermodified derivative of U34 (5-methylaminomethyl-2-thiouridine). The glutamyl-tRNAGln is not used in protein synthesis until it is converted by EC 6.3.5.7, glutaminyl-tRNA synthase (glutamine-hydrolysing), into glutaminyl-tRNAGln.",384,0.99999994,-0.091891214,-0.10051368,-0.09684598,-0.06890846,-0.030475056,-0.03930726,-0.017968148,-0.0023121128,0.0035143525,-0.01595354,0.05587632,-0.06452089,-0.054690488,0.055241685,-0.06938157,-0.016827513,-0.036019307,-0.01871391,-0.013424607,-0.042334158,0.029505268,0.092818655,-0.041808873,-0.020145193,0.031070888,-0.026699284,0.064394586,-0.070085205,0.027424138,-0.054793492,-0.027762089,-0.074025564,0.053601474,-0.017252665,0.025271216,0.045320626,-0.15904115,-0.07397854,0.12661448,-0.006224551,-0.01827776,0.03400834,-0.013134995,-0.06765384,-0.01894106,-0.028150149,0.04813114,0.08762997,-0.0036751863,0.07632787,0.0690594,-0.02480776,-0.056933254,0.044539988,0.030795168,0.037388954,-0.1311222,-0.00881191,-0.005622626,0.032141145,0.015412146,0.0013273554,0.017488541,-0.032815527,0.025601465,-0.07479461,0.120575875,-0.056866925,0.050341316,-0.04667341,0.00086005713,-0.0037602938,0.025825419,0.022034414,-0.010223722,0.04403259,0.03880152,-0.01087743,-0.013888081,-0.023344934,0.0620079,0.014048229,0.086479336,0.063367106,0.036006898,-0.030338468,-0.0024510925,0.086154774,0.028239802,0.069539174,0.13652,-0.01949117,-0.0064031547,-0.054520726,0.015306522,0.0029226178,0.016814763,0.08007922,6.220414e-05,-0.05494472,-0.043780178,0.040270608,-0.026355406,-0.025506137,0.01674553,-0.0010371899,0.029939037,0.033356737,0.04202586,-0.006931713,0.011350553,0.061224088,0.019333523,0.0037626303,-0.06163146,0.03215948,0.03556326,-0.035146367,0.037262335,-0.015267142,-0.03562341,-0.01762505,0.066796206,0.054121975,-0.01858985,0.039521918,-0.09565032,1.9855165e-33,-0.0073397886,-0.031187315,-0.00042952917,-0.0482505,0.03796748,-0.0025479898,-0.1230754,0.024021517,-0.051339183,-0.030277485,-0.11101289,-0.01712106,0.02476288,0.05560352,0.05133892,0.027162582,-0.036392953,-0.04041492,-0.00053928094,-0.048834458,-0.001518083,0.07404348,-0.009653516,0.023967944,-0.011161332,0.06304571,-0.015370508,0.0760229,0.025111629,-0.0064715133,-0.037014317,-0.08097349,-0.060113482,0.046414312,0.083417185,-0.000937525,-0.020625522,-0.010637869,-0.0373642,0.033177093,0.014356532,0.0030004631,-0.057357825,-0.053488933,0.034714334,-0.036257118,-0.009080592,0.03507903,-0.030546583,0.029367087,0.04870783,-0.019929428,0.0008835543,-0.05585976,-0.0484509,0.0176712,0.05620138,0.004603904,0.094693184,0.05501732,-0.031862456,0.025559451,0.0009455866,0.04804941,-0.0465027,0.022272065,-0.093391195,-0.062726624,0.003490482,0.037207413,-0.044311233,-0.034450125,0.03638869,-0.0055296584,0.047898874,-0.046889402,-0.018506672,0.019879196,-0.017125228,-0.0018875258,-0.030911876,0.0028429893,0.054194335,-0.0031260857,-0.08534836,-0.032655787,0.020525744,-0.07468382,0.007090241,0.07676109,-0.017051784,0.011939369,-0.11934444,0.027827691,0.07601922,-4.0677067e-33,0.106087394,-0.11131509,0.053980462,-0.067465685,-0.11221089,0.07704742,0.023419373,-0.09728908,0.006055276,-0.104414254,0.10966927,0.04561523,-0.068384185,0.02897598,0.041578393,-0.025101505,-0.028629495,0.04346753,-0.056218524,-0.02456827,0.04160068,0.035245273,-0.047704443,0.011002764,0.039834615,-0.016647052,0.03576444,0.05957611,0.02912527,0.07185446,-0.054442845,0.018345922,-7.097259e-05,0.058073103,-0.03616064,0.04896393,0.010581959,0.010556537,0.016327662,0.0071059023,0.035227843,0.048526604,0.0025100044,0.017736189,0.010012568,0.092981875,0.0059155,-0.051402133,-0.1077483,-0.043012943,0.13415487,0.048906486,0.04967589,-0.030165294,0.076203816,0.031736564,-0.030127639,-0.073183775,0.011053113,-0.033753265,-0.028899975,-0.08850557,0.019914046,-0.026843369,0.044544492,0.024348611,0.030109923,0.06586187,0.04906138,-0.042420696,0.008363598,-0.05221038,-0.0068213227,-0.016895806,-0.03537686,-0.02196773,-0.043194793,-0.031666394,0.06794335,-0.10492187,-0.00773861,-0.03189436,-0.021254258,-0.018979881,0.037551485,-0.017341452,0.026471388,0.16383831,0.042878576,0.08365246,-0.0064242166,0.052677184,-0.0036916588,-0.018759718,0.058956113,-4.7852822e-08,-0.003537955,-0.07347706,-0.03455972,-0.018050598,0.054377776,0.05913678,-0.068905324,-0.012609617,0.005047193,-0.041068625,0.015607782,0.060290758,-0.09295439,0.013684984,0.0076700104,0.040277373,-0.13386919,-0.033381645,0.021461345,0.029959971,-0.1228684,0.036177017,-0.16192672,-0.017704226,-0.014627222,-0.048364412,0.0049806014,0.06160327,-0.010611019,-0.014834358,0.0059917946,-0.009656844,-0.02361186,-0.0292755,-0.039790742,0.01935912,0.013224767,-0.05021836,-0.0070736087,0.063981116,0.040020134,0.031498138,-0.054670416,-0.0023566876,-0.06886239,0.024740662,0.024511574,0.04988706,-0.073195264,0.07746828,0.04724389,0.0147062205,0.018569626,-0.001395497,-0.07975136,0.0099224765,-0.03230957,-0.09292445,-0.056217834,0.023869624,0.038065795,0.0033209608,0.09428313,-0.009850722 +6.1.1.25,"In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNAPyl, with a CUA anticodon, is charged with lysine by this class II aminoacyl---tRNA ligase. The tRNA and the ligase are encoded within the same gene cluster, and the ligase does not appear to be closely related to EC 6.1.1.6, lysine---tRNA ligase.",384,1.0,-0.031267904,-0.083962455,-0.11249415,-0.08837628,-0.014991341,-0.01186745,-0.041517723,0.0029888826,0.024931189,0.016625261,0.09926273,-0.05963942,-0.021289438,0.023198068,-0.063472375,0.021724926,-0.13620728,-0.06476157,-0.0064283614,0.028041938,-0.013717768,0.14564244,-0.024228452,0.017336093,-0.061693106,-0.05921079,0.08782021,-0.034472756,-0.0044101286,-0.05387578,-0.04782295,-0.018850105,-0.025851827,-0.021081302,0.06567529,0.06561767,-0.058529668,0.0062800837,0.08307497,0.020833332,0.03373375,-0.005378885,0.010585985,-0.03854237,-0.07014507,-0.022435497,0.05702226,0.024048531,-0.0030584617,-0.015374175,0.023414537,-0.06851924,-0.027718225,0.01913236,-0.03623408,0.0687792,-0.08888638,0.006164361,0.0007367247,-0.012189196,0.021890055,0.07512232,-0.005619316,-0.009606196,0.02619982,-0.05261437,0.09958495,-0.03284929,0.13820507,-0.06445441,-0.034976397,-0.036856778,0.047435004,0.059397392,-0.027750151,0.029219504,0.036659528,-0.027555328,-0.0019467846,-0.0013203496,-0.10818885,-0.036876686,0.03145632,0.008569037,0.09473895,0.0005478453,-0.047830094,0.025475495,-0.0012446812,0.045933194,0.07489185,-0.0070823566,0.05887262,-0.044189516,-0.04260022,-0.011317388,0.060581267,0.036340117,0.018794704,-0.013080982,-0.021152068,0.06679514,-0.10319213,0.0019043767,-0.02505281,-0.059853543,0.038691018,0.0239436,-0.03444331,-0.02567529,0.011838174,0.046013366,0.047603585,0.019411562,-0.03632756,0.041345254,0.07445211,-0.019707154,0.07935413,-0.02282648,-0.0006039983,0.019181322,0.038338818,0.053577498,-0.031655975,-0.005952141,-0.0688435,1.44739005e-33,-0.01731149,-0.006983178,0.03136974,-0.025616309,0.08563593,0.019365927,-0.11393463,0.042485397,-0.0073894006,-0.09294427,-0.101396404,-0.02944601,0.029130343,0.012336223,-0.0006964482,-0.020210478,-0.102127455,0.027729008,0.03172183,-0.017953359,-0.0054053534,0.111759156,0.041873287,0.0106627215,-0.007034451,0.046119217,0.0048701204,0.013575562,0.07620662,0.035762142,-0.04074208,-0.08356234,-0.003308036,-0.0060352483,-0.0058668028,0.06114497,-0.02377372,-0.042905133,-0.008582013,0.08900129,0.046709456,-0.03997648,-0.017359046,-0.016312674,-0.044574913,-0.03547709,-0.056420296,0.044229936,-0.07539033,-0.049125884,0.031804204,-0.06881739,-0.0070244074,-0.028550295,-0.060222067,-0.052261557,-0.010420551,-0.049482297,0.031352136,0.12025227,0.044670485,0.073371395,-0.0044457926,0.055864222,-0.055087976,-0.073998146,-0.018714916,-0.04973947,0.024694804,0.01091276,-0.051244643,0.005285709,0.084851414,0.006788902,0.037292767,-0.046612818,-0.08724676,0.039897874,-0.02727194,0.056982737,-0.0014323212,-0.015131238,0.009228126,0.002331217,0.014428705,-0.04585999,0.034567907,-0.043226443,0.0068132165,0.042369112,-0.020833725,-0.024754336,-0.07465876,0.004183586,0.048119403,-3.0687149e-33,0.0061574685,-0.07211297,0.07080321,-0.057638023,-0.070222355,0.024430964,0.031974185,-0.07367651,-0.009524249,-0.108105235,0.12061499,-0.0018295561,-0.033796925,-0.023578467,0.074706644,-0.036672506,-0.011473261,0.016939558,0.0073700077,-0.052458227,0.021756615,-0.0392564,-0.037199903,0.0019259222,0.07174893,-0.027950222,-0.03547113,0.09446406,-0.0046042185,0.07480628,-0.020341763,0.015426336,0.030689927,0.024343884,-0.12691519,0.03844761,-0.056050263,-0.004529465,0.051830117,-0.030055782,0.06737859,0.024373095,-0.0049928194,0.05958108,-0.044193603,0.052916873,-0.024349974,-0.03774397,-0.0031270129,-0.0033184416,0.1222521,0.022103248,0.06569739,-0.0014289343,0.04196217,0.024877863,-0.031890806,-0.015847113,0.015392201,0.013489828,-0.0056784903,-0.0517934,-0.061402883,0.030015381,0.082704045,-0.048106704,0.00069497246,0.09861312,0.045045167,-0.037706684,0.07901904,0.033998635,0.023874534,0.03933346,-0.06901995,-0.050911695,-0.06829058,0.029559502,0.047322474,-0.039773382,-0.057090513,-0.049432263,0.056709606,-0.026276635,0.05202185,-0.031264838,0.061622046,0.113718756,0.029772734,0.05933855,-0.0012495592,-0.00029972338,-0.017065492,0.0042709406,0.081595935,-4.0269004e-08,0.046865966,-0.11400195,-0.052014407,-0.023662325,0.00912934,0.072363764,-0.07998387,0.045179527,0.0026981824,-0.008999177,0.0037574975,0.03260519,-0.0035258464,0.010089819,-0.02473735,0.118584625,-0.06933174,0.029745294,0.01791463,-0.017935563,-0.110588074,0.05140669,-0.094505675,0.013129067,-0.05083008,0.021569248,-0.017525144,0.09842955,-0.050043106,-0.054208547,0.013470871,-0.035724867,-0.0111723235,-0.03122555,-0.06542536,0.046586145,0.019084515,-0.058578633,-0.039423004,0.0630172,0.013570652,-0.021939786,-0.05720685,0.02376643,0.037987404,-0.024074987,0.003737787,0.08616366,0.0039217565,0.03878669,0.06752313,0.05985043,0.06634776,-0.044689737,-0.075093344,-0.016157752,-0.06576786,-0.063303776,-0.07659993,0.041983254,0.054401867,0.018843308,0.1581922,-0.031496916 +6.2.1.1,Also acts on propanoate and propenoate.,384,1.0,-0.0098693855,-0.031509545,0.006597545,0.06695597,0.042874422,0.068884335,0.027094807,-0.022836784,-0.027734572,0.0426771,0.08019062,-0.010205694,-0.14659804,0.053305693,0.03263611,0.08383773,0.004861608,0.10295902,-0.012091026,0.030901007,0.041467648,-0.037579156,0.012282077,0.020693798,-0.034659628,0.016199473,-0.057868615,0.0059686345,0.081969924,-0.028676324,0.01700755,0.048736647,-0.033953134,0.0040990436,-0.018778043,0.078200415,-0.011781719,0.020192845,-0.02734589,0.026871165,0.070162736,-0.13175993,-0.021894213,-0.008859922,0.0019645942,-0.004293135,0.002534117,0.043428246,0.028762367,-0.025394293,-0.111830875,-0.076516,-0.055881057,0.05265684,-0.045994192,0.04148279,-0.007322132,-0.002775691,0.054405443,-0.037077777,-0.044825148,0.014730421,-0.09133631,0.040927656,0.044662766,0.023132557,0.004793368,-0.015969474,0.022047298,-0.06134094,0.0932057,-0.041457485,0.049789205,0.012570751,-0.029043471,-0.005681884,-0.0062093134,-0.020416696,0.008030939,-0.09661288,-0.020966344,0.03109873,-0.019748941,-0.061218686,0.022632804,0.002881626,-0.04111822,-0.053263362,-0.053951122,0.08908737,0.0062702806,-0.041466966,0.030268319,-0.049710933,-0.04383842,0.02806481,0.024757331,-0.025972785,0.030992214,0.028094348,-0.06280901,0.010416385,-0.070236236,0.0032815856,-0.036229122,-0.051194873,-0.07378368,-0.04517537,-0.006568319,0.07902256,-0.046083935,0.013802101,0.024475148,0.07241992,0.02535321,0.08653868,-0.02588916,-0.026886294,0.015308516,-0.022137988,0.029517949,-0.053243883,-0.017307116,0.014801872,-0.037085593,-0.024938539,-0.0026942352,-5.0833362e-34,0.08359824,-0.057151947,0.0351558,0.054671984,0.024619676,0.05837405,-0.043604616,-0.057478476,0.013182059,-0.090996295,-0.012586258,-0.0414194,-0.009227117,0.066843756,-0.06617426,-0.037183262,-0.06333193,0.10022112,0.019676667,0.014321973,-0.0081225,0.07983432,-0.08990901,0.0018016649,-0.028769825,-0.025865769,-0.022917312,-0.0011631546,-0.06690315,0.019391255,0.07322942,-0.008292758,-0.014817662,0.033509333,-0.027478253,0.05576103,-0.024165584,-0.108404785,-0.029471057,0.016051045,0.0024500967,0.02098104,-0.016522646,0.0029041339,0.033313464,-0.043000415,0.013541907,0.021726973,0.04527685,0.044208687,0.0580031,-0.0019596042,0.08487642,-0.09366731,-0.021921957,0.0736292,0.008884769,-0.0030750916,-0.0132131865,-0.014524055,0.00071489124,0.069297515,-0.030598994,0.008667955,-0.024966663,0.022494437,-0.07813127,-0.04818735,-0.03440175,0.03973013,-0.07136425,0.011113132,0.06242363,-0.028202994,0.015244169,-0.029682098,0.0036062342,-0.018143693,-0.058504906,0.017871117,-0.07228855,-0.058818992,0.0050065024,0.06289211,-0.01889937,0.038801115,0.006934457,-0.05080272,-0.006243486,-0.024786089,0.090538844,-0.04022132,0.011922155,-0.023921084,-0.043850753,-6.193321e-34,-0.06670225,-0.109380424,-0.02067745,0.10156827,-0.00303236,0.019788826,-0.055094775,-0.058337443,-0.03590513,-0.047770273,0.021970455,-0.019385468,0.043153603,-0.00783407,-0.018407954,-0.009171767,0.05064339,0.10532048,-0.043490212,0.026839212,-0.015235446,0.080837935,0.010240811,0.08637848,-0.037701026,-0.0005974305,-0.05714729,0.010126557,0.0035209951,0.003092496,-0.005947291,0.033384528,-0.16502598,-0.04795651,-0.018096624,0.032137137,-0.02856257,-0.013778055,-0.03960132,-0.041874293,0.025355782,-0.017109388,0.03050923,0.10921908,0.018769307,0.047257707,0.08399802,0.023495656,-0.023589738,0.034526132,-0.0193402,0.02924711,-0.06490082,0.032112382,-0.00045687926,0.006516834,0.047920384,-0.13792622,-0.042362973,-0.013351817,0.00790302,-0.03651981,0.009545744,-0.029416721,0.07784752,0.010917035,-0.058690164,0.06273698,0.120635256,0.0034080087,0.14207579,-0.043562833,-0.04125223,0.017985623,-0.045205455,-0.074959464,0.030100457,-0.10881248,-0.026627043,-0.04207898,-0.08826928,-0.07387917,0.03519032,-0.0111697065,-0.0583068,-0.005288059,-0.043050952,-0.035716403,0.0032941077,0.11183053,-0.103896394,0.009704725,-0.05660613,0.048372727,-0.019155663,-1.9161122e-08,0.03008525,-0.010548324,0.15933472,0.03195633,0.009767706,-0.0435862,0.08132091,0.058874432,0.03952277,0.004599499,-0.050429117,0.05867465,0.1200813,0.008680661,0.13727297,-0.02674363,0.07548792,0.04380588,-0.13180067,-0.0058210716,-0.08228025,-0.06765031,-0.018377941,0.033074334,-0.0005498302,-0.023956355,0.018531175,0.111816145,0.08156671,0.026139135,0.049947284,-0.04003248,0.0022551056,-0.015726186,-0.032098673,0.019378206,0.060085338,-0.028124884,0.003238236,-0.015528362,-0.02853084,0.013747798,-0.04127629,0.10688922,-0.036149032,-0.0073527684,-0.008529832,-0.011637353,0.019823495,0.009380997,0.09450392,0.0055689286,0.024101246,0.0052345316,-0.035647262,0.05558263,0.04818215,0.017660795,0.105708115,0.004892495,0.08814838,0.011950643,0.13755344,-0.019906672 +6.2.1.2,"Acts on fatty acids from C4 to C11 and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.",384,1.0,-0.012590614,-0.10604081,-0.03729254,-0.017443128,0.01743144,0.10982774,-0.086310156,0.023376277,0.0041058525,-0.065510005,0.041532915,-0.10331702,-0.050762758,0.06806695,0.00025615617,0.051165532,-0.026390685,0.03675127,-0.05155365,-0.026007183,0.053806204,0.017601263,-0.052293953,0.021697544,-0.045079492,-0.01838874,0.059133485,-0.028664393,-0.006066263,-0.033857904,-0.018348088,-0.0866082,0.037610482,-0.068910114,0.007546408,0.004634935,-0.0009211594,-0.08023976,0.07513345,0.010229026,0.08163544,-0.056553736,0.007252329,-0.020476423,0.006297148,-0.010893501,0.08127016,0.037852272,0.037629675,-0.0813593,-0.05744099,-0.05027982,-0.0694313,0.06002754,-0.027224202,0.0072810617,-0.06252568,0.023268705,0.0026142546,0.035681434,0.039715443,-0.04324808,0.06587904,0.080525644,-0.011946424,-0.045107145,0.025639221,-0.043076802,-0.031098831,-0.03984181,-0.046008028,-0.05385216,0.112683445,0.00047171445,0.013625843,0.01139561,-0.016767815,-0.06329191,0.03802651,-0.1110646,-0.011502213,-0.058402162,-0.030210037,0.1040554,-0.014200094,-0.07015929,-0.0019030296,-0.043007094,0.019801117,0.062306065,0.021284437,-0.028623372,-0.05202032,-0.03844457,-0.0662156,0.044116247,0.045799028,0.0049739894,0.092973284,-0.013842399,-0.02312961,0.051920235,-0.06403481,-0.07929969,-0.0178383,0.016946977,0.011930927,0.05678683,-0.019267999,0.052272696,-0.019632144,-0.010610577,-0.012532457,-0.0076555717,-0.05270234,-0.010050583,0.0877739,-0.12412752,-0.11034004,-0.10788256,-0.037785575,-0.1152247,0.07218464,0.03033668,-0.01932418,-0.00021548686,-0.048969124,-3.1392697e-34,0.05790905,-0.035139747,0.03345431,-0.06788948,0.060789913,-0.046340246,-0.055138152,0.020052075,-0.01259972,0.017681133,0.008336972,-0.033500616,0.029466163,0.060156267,-0.005188102,-0.031672616,0.019487157,0.0022431437,0.047800187,0.0063520283,0.021192608,0.10654299,-0.014501899,-0.037951145,0.027654195,0.04031852,0.027260311,-0.05498578,0.027426029,-0.007943775,-0.000938141,-0.010424999,-0.1056156,-0.014970457,0.07474848,0.0203343,-0.0591875,0.024312457,-0.0013903981,0.06626704,0.062456533,0.0110275755,-0.037194837,-0.08324428,0.07964281,-0.025016164,-0.046631623,0.14763251,0.07758168,0.07988648,0.052312836,-0.07843103,0.08312171,0.02383538,-0.012490998,-0.034557525,-0.08144652,0.033711396,0.009761143,-0.030242866,0.022216646,0.026060281,-0.08618907,0.014244298,-0.011035036,-0.037865035,-0.078795776,-0.034200225,-0.006055397,0.008945543,-0.0270735,0.041554146,0.019503504,0.026463166,0.006522768,-0.027838703,-0.09820753,0.025222687,0.028723631,0.009905057,0.009523265,0.002087374,0.07315985,0.0032033075,-0.079815194,0.04667632,-0.0056576515,0.0095539065,-0.011803367,0.0014473405,0.05422683,-0.10139521,0.019671706,0.031813778,0.012802364,-2.222502e-33,0.04787943,-0.044863854,0.07196605,-0.051343482,0.021937108,0.01045987,-0.03784995,0.0432924,0.054325912,0.01274563,0.07805665,0.010757555,0.020649679,-0.047510073,0.011322979,0.027623134,-0.034511186,0.01847265,-0.089523815,-0.0444406,0.038667668,-0.021344304,-0.0626534,0.113952756,0.06042679,0.07735782,0.01633052,0.07310481,0.001479417,0.12162781,0.009565017,0.0054564057,-0.036420584,0.008984286,0.041014556,0.010394926,-0.069175735,0.07864053,0.04065435,0.04321379,0.05598636,-0.004839306,0.04336328,0.07055492,0.01020428,0.046390317,-0.09340986,0.01881794,0.010577969,-0.060326982,0.010253459,-0.044910546,0.0061611547,0.0033732995,0.07632083,0.08465083,-0.023310956,-0.032132216,-0.02755598,-0.11243687,-0.094797336,-0.09393116,0.039177213,-0.036881976,-0.031241778,0.005371957,-0.08154476,-0.040989686,-0.022251183,-0.002706843,0.017999576,0.007393872,-0.03368967,-0.021778384,-0.048843935,-0.0636907,-0.027522516,-0.10197882,-0.016016437,0.06930726,0.012961553,0.004509313,0.014297278,-0.0862164,-0.00095484284,-0.015730636,0.02545572,0.051677722,-0.010789155,0.019599091,0.016415605,0.07672703,0.027612392,0.019012697,0.027614746,-3.451579e-08,0.026877617,-0.040392354,0.12110801,0.06660479,-0.10166125,0.037178323,-0.027200922,-0.0026795156,0.066841245,-0.067345664,-0.010247004,0.08416683,0.027570087,-0.010079648,0.056087967,-0.04350207,-0.105356,-0.028875953,-0.032573953,-0.050085396,-0.10155988,-0.079075366,-0.054410223,0.036414493,0.05016721,-0.038333718,0.033383016,0.0041191033,0.00091170956,0.02754837,0.04654437,0.00014500447,0.020654026,-0.016178679,0.0002546015,0.015850374,0.030957669,-0.01659033,-0.05569987,0.057151917,0.083836585,-0.037843928,-0.10777854,0.0028487542,0.06735762,0.004754181,-0.077880636,0.06590314,-0.0228103,-0.0077292197,0.04464513,0.021329409,-0.041066978,0.037324067,-0.03970673,-0.020737942,0.008196154,-0.0057759383,-0.046707176,0.026141174,-0.009889032,0.08260502,0.14930709,0.051557645 +6.2.1.3,"Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.",384,0.99999994,0.057689622,-0.10950189,0.019709777,-0.005254293,-0.013740714,0.093775496,-0.09646032,-0.0035589805,-0.022177095,-0.044913474,-0.034223728,-0.06120883,-0.08636362,0.02787308,0.042056028,0.0018376485,-0.022556458,-0.0662696,-0.05733856,-0.07330643,0.0138022285,-0.01950552,-0.03889799,-0.043295827,-0.014587024,-0.02640121,0.072993554,-0.04645303,-0.0042099413,-0.06102167,0.04796872,-0.06349565,0.007499629,0.001625483,-0.03983134,0.04231738,-0.077489585,-0.035110187,0.003180357,0.001416748,0.06263476,-0.056062415,-0.032309074,-0.00053498376,0.0124634495,-0.057248227,-0.010541319,-0.048486922,-0.014903523,-0.0069348686,-0.07246188,-0.060692556,0.011129163,0.06033383,-0.019880274,0.022439701,-0.08477813,0.021989975,-0.0018971071,-0.00048893475,-0.031416632,-0.027559211,0.08560112,0.008556288,0.08023574,0.012202134,0.019157497,-0.10451603,-0.059745077,-0.07994818,-0.05505271,-0.066646576,0.023377225,-0.04271087,-0.0100510465,-0.013062224,-0.094095945,-0.072961815,0.03788863,-0.113153785,0.0026958887,0.0056087626,-0.04898565,0.056171,0.042885303,-0.008652945,-0.029519513,0.028612053,-0.08083525,0.13087787,0.029874742,-0.08516844,-0.06181666,-0.0527066,-0.09337927,-0.013910943,0.006340052,-0.009528672,0.060537837,-0.0064436835,0.024248613,0.061031166,-0.048986945,-0.017787796,-0.00067588734,0.08452285,-0.00086314604,0.049220067,-0.026982967,0.009182481,-0.009851408,0.00075774547,-0.0028295484,0.032254253,-0.0131740635,0.030011425,0.04057336,-0.06011366,-0.032941096,-0.02252901,-0.0129947,-0.07200764,0.120750345,0.0075882664,0.0028915938,0.04104272,-0.037926424,1.3191522e-33,0.081631534,-0.11718338,0.032141756,0.012188628,0.056789044,-0.024114091,-0.026926769,0.04492058,0.026380224,0.031916954,-0.013904501,0.049862564,-0.01229366,0.13749205,-0.006773222,0.052788626,0.020490056,0.029636897,0.047700234,-0.06894516,-0.015802776,0.031506278,0.0008993727,-0.058760516,0.010319905,0.0135052055,-0.07685221,0.06004302,0.015432894,-0.003281738,-0.07873309,-0.049798317,-0.0568854,0.051447775,0.05888493,0.08270935,-0.006768083,0.030631779,-0.0021704887,0.057121653,0.10146767,-0.052810695,0.036212288,-0.05702936,0.023824006,-0.004435345,-0.07581945,0.069310606,0.04089725,0.0063398196,0.068014234,-0.06716173,0.12150337,-0.042687077,0.00917964,0.021665215,-0.08096544,0.04511952,0.0050946637,0.04256608,0.061018884,0.043770853,-0.08903767,0.08901852,-0.013851183,0.031125607,-0.15812363,-0.047741987,-0.074077815,0.0734389,0.018995836,0.011131414,0.10093363,-0.023541138,0.037005242,0.015127298,-0.0940255,-0.014279261,-0.055058982,-0.0010475385,-0.024707537,-0.004153139,0.015746426,-0.019367335,-0.0486268,0.049198918,-0.013946505,-0.096797265,0.0067574796,-0.008845369,0.00112436,-0.023857241,-0.03190767,0.019372735,0.04991146,-3.9783967e-33,0.040315226,-0.03587074,0.043679185,-0.055469543,0.036834907,0.05002194,0.035578635,-0.0145576345,0.026554761,0.04177625,0.09240417,-0.008697884,-0.019268619,-0.056322534,0.034148607,-0.012887337,-0.011092365,0.08969589,0.016996492,-0.05395309,-0.023370352,0.028165402,-0.046461344,0.09292927,0.016407818,0.06810047,-0.055434845,0.058781307,0.010283014,0.04640278,-0.063103095,0.06462409,-0.05743178,-0.0032258814,0.014458629,0.024826849,-0.058127694,-0.0208717,-0.044593234,0.023686774,0.014656502,0.01675235,0.035711005,0.052031267,0.053179916,-0.004266718,-0.02228026,-0.041124374,-0.02428085,-0.052529443,0.05407384,-0.008886868,0.0074949297,0.039293285,0.06279673,0.12141506,-0.028663972,-0.034670215,0.052163787,-0.103678636,-0.07560481,-0.029882127,-0.0053878315,-0.019550193,0.011638651,-0.024164079,-0.04247097,-0.037541106,0.013935311,-0.0035402358,0.037063353,-0.028444214,-0.043048825,0.034672666,-0.03861012,-0.010031402,-0.014475531,-0.04937934,0.03449237,-0.03567861,-0.017279204,0.01410008,-0.023641372,-0.07162175,0.01816565,-0.029996954,-0.072051406,-0.02966418,0.024393192,0.030858785,-0.006355979,0.029314471,-0.099844284,-0.042069808,-0.049037457,-3.797347e-08,0.039577197,-0.020230548,0.027394388,0.028495444,-0.035403267,-0.02475587,0.0085389055,0.036824223,0.03332235,-0.042061944,0.024294369,0.058880083,0.034925263,-0.00887629,0.06859149,0.027657168,-0.09508568,0.0034242864,-0.013526652,-0.022588285,-0.029804807,-0.05952134,-0.0061830375,0.06946307,0.0239374,-0.05997651,-0.02182451,0.12226873,-0.016686082,0.0705306,0.032606114,0.011432371,0.025851652,-0.013946719,0.101886116,-0.008045267,0.050015356,-0.021289488,-0.10649049,0.12540713,0.046591066,-0.065567374,-0.11677867,-0.0048471214,0.031807948,-0.04358681,-0.027592342,0.041027218,0.05917045,0.01024102,0.01227055,0.049689714,-0.027842473,0.041628778,-0.0124496175,-0.039680514,-0.00047139084,-0.04030443,-0.008371638,-0.057639636,0.1503032,0.15748028,0.12549354,-0.014767927 +6.2.1.4,"Itaconate can act instead of succinate, and ITP instead of GTP.",384,1.0,-0.05366845,-0.023579063,-0.030591989,0.01056653,0.016312746,0.051429186,0.021863852,0.07402536,-0.042067822,0.026045045,0.008338545,0.022118434,-0.03489448,0.039064057,-0.002687706,-0.0107690655,0.12141214,-0.11752051,0.049255606,-0.0023710479,0.029519971,-0.015109986,-0.035307128,0.018562833,0.027455788,0.030392911,-0.059890065,0.004722758,-0.041145995,-0.045004595,-0.0752541,0.03893387,-0.0006857065,-0.0054495856,-0.06500177,0.06961077,-0.04077003,-0.025933702,0.003139733,-0.103587605,0.029181706,-0.00071554026,-0.07723201,0.043957874,0.004514767,0.0039702277,-0.09508647,-0.0102749355,-0.07865689,-0.031822283,-0.05618311,-0.036519364,0.040066283,-0.013518458,-0.04278776,0.055340767,-0.088088706,-0.04032806,-0.0036269857,0.014522785,-0.100912906,-0.016013784,-0.03441752,0.051457636,0.09556094,0.06821016,0.028870746,-0.040738918,-0.009500034,0.0030930494,-0.05080771,-0.0052638818,0.019221745,0.08211247,0.007106972,0.05915856,0.02698405,-0.015828585,0.057352044,-0.016143257,0.005256852,0.08036921,-0.0428124,0.03465723,0.031023132,-0.024992,0.038383838,-0.035178453,-0.022220274,0.066223875,0.060654454,0.02776841,0.038480517,0.04521214,-0.09266067,-0.025147045,0.028218707,-0.041384056,-0.008698088,-0.07336793,-0.017090075,0.027087383,0.014066481,-0.015053918,-0.06357429,-0.05342285,0.008491357,-0.117656216,0.03611052,0.01104632,-0.050426744,0.010005882,0.0028127178,-0.01802809,-0.0331503,0.100203484,-0.10041658,-0.019112658,-0.019340452,-0.003916084,-0.058994427,-0.06017659,-0.0090830885,0.056482214,-0.08651629,-0.02284551,0.006471605,-5.3232326e-34,0.009378967,-0.049765736,0.04369874,0.007547465,0.04596084,0.035744306,-0.05752487,0.055632304,-0.036231656,0.01642651,-0.09196588,-0.053679623,-0.024834348,-0.00082129816,0.011465816,0.006808502,-0.10336865,0.039626393,0.0009389282,-0.05424352,0.019844282,0.088064425,-0.03738432,-0.052997105,0.002868196,0.10485418,-0.045824397,-0.011318059,0.04085,0.037846923,0.061965127,-0.0406829,-0.097106695,0.07534671,0.022268016,0.00050723436,-0.018357573,-0.076612584,0.01348256,-0.0023399028,-0.011324842,0.084103905,0.017642349,0.0013606611,0.06492912,0.021911435,0.043056753,-0.030059773,-0.039662626,-0.013723899,0.027976036,0.019527774,0.020528344,-0.0006933308,0.048227753,0.100285515,0.041370336,0.08072782,0.037884176,0.052494183,0.061099272,0.045263115,0.008901442,-0.047811847,0.034999635,0.09996016,-0.12778243,-0.10333764,0.037736908,0.026282867,-0.0017821612,-0.0312407,-0.0111057125,0.07928198,0.032812726,-0.054861214,0.02235,0.06284714,-0.07043384,-0.0043403073,-0.041638225,-0.059150398,-0.03854217,0.0038535045,0.022052761,0.0068061794,0.024457112,-0.029292723,-0.048825365,0.07594822,0.038283587,0.036441457,0.05844587,0.02659065,0.051941775,-1.9760235e-33,-0.0020553342,-0.12644538,-0.0314559,0.06447357,0.01146061,0.07055693,0.013673961,-0.06991104,-0.008471165,-0.003550025,0.05334747,0.022779666,0.04335828,-0.026423177,0.036055207,0.007574615,0.035088886,0.038858656,-0.10667984,0.05945728,-0.06983738,0.044212732,0.014656379,0.015871532,0.037702817,0.020839391,0.03480032,0.04911124,0.048201084,0.02220559,0.040338434,0.09548025,-0.13434596,-0.057144344,-0.0015489007,-0.10173847,-0.028716806,-0.045575712,-0.038909793,-0.04318539,-0.04444619,-0.014408795,0.033809945,0.050399702,0.035130434,0.06838959,-0.036228992,-0.017160993,0.012946826,0.072694995,0.06784582,-0.07012624,-0.0874479,0.018356672,0.023392983,-0.039820805,0.11648134,-0.10727667,-0.081234224,-0.08505707,0.05846389,-0.027459117,0.018142452,-0.06902817,0.062600054,0.035139672,0.027328689,-0.009772697,0.07665788,-0.05089918,0.06054208,-0.08931193,-0.0053034807,-0.06843145,-0.04458855,0.09463996,0.010406794,-0.02884824,0.038318302,-0.06292388,-0.0110508045,0.047930688,0.056223106,-0.025743876,-0.02936613,-0.055637464,0.031679194,0.00504814,0.016436974,0.07324969,-0.07217305,0.077791706,0.03379968,0.036411826,0.0019512945,-2.2541977e-08,0.019134695,-0.016119301,0.0890956,0.037985895,-0.025623662,-0.04804088,-0.038404103,-0.06362005,0.022112627,-0.021636058,-0.041782368,0.040928032,0.026906459,0.0060916855,0.0806482,-0.087346226,0.011519643,0.073764585,-0.06153629,0.010291331,-0.12793568,-0.044642508,-0.03378748,-0.031502306,0.058922082,-0.009472998,-0.017669624,-0.05057721,0.14890434,-0.07687795,-0.00041015874,-0.023415351,0.07049866,0.0027808272,-0.07462259,0.05818097,-0.001212631,-0.023676157,-0.0012125467,-0.0142385205,0.056360297,-0.058773153,-0.032292333,0.04239991,-0.115324244,0.037815776,0.07497367,-0.023061369,-0.051616844,0.087689675,-0.046843674,-0.027161974,0.03154337,0.008806596,0.061551314,0.024020925,0.010909753,-0.061613377,-0.021850415,-0.040341653,-0.023028178,-0.03499192,0.05896325,0.034519188 +6.2.1.6,GTP or ITP can act instead of ATP.,384,1.0,-0.08582882,0.015075447,0.023287598,-0.021912092,-0.005106574,0.0062912656,0.03617444,0.07319129,0.02783006,0.03276309,0.0037741654,0.044134572,-0.06623098,0.1300168,0.036071412,-0.029706305,0.07811925,-0.03335104,0.06825142,-0.0029958724,0.046892654,-0.0076520764,-0.022102116,0.0021178103,-0.04411889,0.005549583,-0.027939811,0.045554925,-0.0077246344,-0.048074637,-0.13366348,0.0059334417,-0.03500295,-0.0053261695,-0.034090333,0.072000735,-0.068550855,-0.022082094,0.011806696,-0.065312505,0.050077736,-0.007374284,-0.066136904,0.035640568,0.025028491,0.034269504,0.014163778,0.033296596,-0.029342797,-0.048077624,-0.008186791,-0.007612122,0.04029162,-0.011582565,-0.01780201,0.011748505,-0.11238615,-0.050484445,-0.048575066,-0.002248689,-0.06462785,-0.024559248,-0.042506665,0.03612757,0.108589344,0.036722694,0.01904473,0.02141791,0.02019022,0.014702065,-0.061840218,-0.017186487,-0.0653445,0.08145042,0.010501306,0.052146792,-0.024592793,-0.03393939,0.089527175,0.035909545,0.01950475,0.05978209,0.033585817,0.010502375,0.060505923,-0.038745362,-0.011477084,0.023905216,-0.03490688,0.030365735,-0.015888788,0.039069645,0.08060975,0.03983031,-0.03486006,0.011027308,0.015997604,-0.06041368,-0.08332773,-0.016120791,0.034983125,0.09132565,0.029980563,-0.0159169,-0.031900927,0.018167507,-0.013670467,-0.01924491,0.038752556,0.007339603,0.00045294993,0.031586975,0.011710603,-0.02243798,-0.03290958,0.09958128,-0.102567114,0.028809324,-0.034370508,0.03316058,-0.09081581,-0.1384262,-0.056303445,0.059484515,-0.07739663,0.026577465,0.029239064,-1.5277754e-33,6.5289255e-06,-0.05853646,0.038847513,-0.016921757,0.012065495,0.007436028,-0.03115676,-0.014648308,-0.03509132,-0.082065836,-0.025423385,-0.07827493,0.009854366,0.012357037,0.0025566828,-0.025617484,-0.12871794,0.0978779,0.04080347,-0.0934933,0.031386904,0.05515586,-0.0054797744,-0.09323635,0.05499556,0.07241342,-0.08599251,-0.102524035,0.044732418,0.015514748,0.029744852,-0.041927725,-0.12727636,0.09386806,-0.025767528,0.039864603,-0.048768982,-0.08026152,0.075559005,-0.037628796,-0.03842601,0.05529402,-0.020398708,-0.028516203,0.016611049,-0.04847408,0.00076646917,-0.011566364,-0.108162805,-0.032191392,0.110708,-0.029528089,0.023466785,-0.028877748,0.020117573,0.048072282,0.05050087,0.044251323,0.021988567,0.10797658,0.10178317,0.060754586,-0.021700982,0.046370137,0.018604599,0.08406676,-0.124681704,-0.14247033,0.016774401,0.112787634,-0.017129812,-0.013411922,0.055884212,0.004722632,0.029310254,-0.045584697,0.010622605,0.019188574,-0.07063657,0.05758468,-0.05880095,-0.10088581,-0.03955584,-0.009408481,-0.05907936,-0.01248964,0.037740726,-0.05945164,-0.0059365793,0.034058247,0.06522511,-0.0266944,0.004572596,0.081241176,0.01844476,-9.374788e-35,-0.008476843,-0.098933496,0.025105493,0.024391966,0.028547162,0.03832802,0.08477245,-0.12673733,0.024358073,0.025649799,0.036314502,-0.011577302,-0.03480574,-0.014947412,0.04595881,-0.014932973,0.030145826,0.0025686196,-0.07550568,0.03621,-0.033076487,0.04820262,0.06821584,0.06100462,0.017277263,0.037025034,-0.0031701857,0.022968177,0.0904183,0.039381094,0.006344288,0.051845312,-0.11969829,-0.04512328,0.04215351,-0.012654723,-0.0005822675,0.0486027,-0.009890138,-0.026347391,0.05661606,0.023468465,-0.00050827244,0.045858137,0.012641651,0.09520561,0.023628237,-0.003943713,-0.014441268,0.017967058,0.034077514,-0.0037302047,-0.097156845,0.037650064,0.039034553,0.023128353,0.07191452,-0.069758736,-0.09963189,-0.079201125,-0.03693192,-0.041930925,-0.0029510267,-0.040231142,0.058951285,0.050699104,-0.035495035,-0.04180566,0.017161436,0.012863802,0.06045371,0.04423075,0.025701158,-0.054633535,-0.00010621688,0.07910455,0.027570954,-0.040640287,0.0058687353,-0.07366859,-0.09714073,0.116140485,-0.007079004,-0.048846006,0.0153369615,-0.07162403,0.0004729097,0.035356063,0.046005685,0.035731878,-0.005512677,0.02613314,0.020579292,0.014204505,0.001249389,-1.7219001e-08,0.028725712,-0.009701108,0.13482988,0.006187311,-0.048196103,0.008624965,0.011859163,0.008625371,0.09664562,-0.014017064,0.01765544,0.03667673,0.069655314,-0.029324412,0.088949576,-0.028299615,-0.04656267,0.025673315,-0.057688605,-0.057453144,-0.11492348,-0.045064628,-0.02729689,0.07890046,0.0114918435,-0.012035881,-0.0039328914,-0.007728129,0.07991698,-0.091056526,0.012511912,-0.027370725,0.034631427,0.06875117,-0.030695375,0.023929454,0.0040882467,-0.0154946,-0.07316522,-0.0005745358,-0.055730656,-0.07258925,-0.0603782,0.034285046,-0.014804513,0.026437107,0.011448155,-0.031264417,-0.017711494,-0.0012592614,-0.016993089,-0.008593589,0.014963409,-0.011476648,0.02065267,0.023665357,-0.011899047,-0.0657071,-0.025252387,-0.050222374,0.0077298274,-0.021283552,0.08460857,0.020839183 +6.2.1.7,"Requires Mg2+ for activity. The mammalian enzyme is membrane-bound and catalyses the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates [7]. The bacterial enzyme is soluble and participates in an anaerobic bile acid 7 alpha-dehydroxylation pathway [5].",384,1.0,-0.03286691,-0.13827167,-0.021774253,-0.0038477643,-0.009230245,-0.00072246545,-0.036235638,0.015388143,-0.07512206,0.018011933,0.014201814,-0.0096182125,0.000958694,0.04151233,0.015948476,0.021930484,0.0061365105,0.04052575,-0.009683999,-0.039801564,0.032467827,-0.058294535,-0.022866962,-0.029694611,0.025953582,0.011447851,0.1361957,-0.07129161,-0.004340954,-0.030034443,-0.05402672,-0.034610856,0.096443415,-0.097684175,-0.0106416205,0.079834916,-0.049641017,0.035423353,0.025395533,-0.036208797,0.033437487,-0.00615664,0.033712894,-0.050849825,-0.0003757822,-0.09535402,0.12141876,-0.01853115,0.050048128,0.05944391,-0.067372866,0.02568685,-0.052880313,0.0039397334,0.0036320272,0.0347505,-0.043277834,-0.063144565,-0.035985686,0.005948302,-0.015568206,-0.004264039,0.023626514,-0.03115906,7.0775124e-05,-0.04513006,0.051159557,-0.053546645,0.0652408,-0.054573987,-0.031548135,-0.055978484,-0.041994337,-0.011108041,-0.036603596,0.022024533,0.025538517,-0.08343874,0.0627392,-0.031364873,-0.025334392,-0.057534505,0.054334376,0.10591604,0.08014962,-0.04612548,0.044368543,0.02778833,-0.00043712242,0.070397675,0.05505185,0.062176324,-0.020229476,-0.021195583,-0.05623509,-0.030179918,-0.023091152,0.033080813,0.019865692,-0.016529327,0.028657999,0.09839947,0.00092253654,-0.07753914,-0.022913134,-0.0032473495,0.0063821347,0.050055083,0.012273955,0.0009721153,0.090595834,-0.021860925,0.060746707,0.023624945,-0.0034469143,0.15133893,-0.017308086,-0.12188134,-0.007657362,0.062314693,-0.03290752,0.050904687,0.05282499,0.07716178,-0.022824926,-0.004266277,-0.025751147,4.2593744e-33,-0.0146581745,0.014074388,0.016320363,-0.002702539,-0.03855825,0.015301847,-0.04435527,0.004323138,0.011889427,-0.037903015,0.0055912444,-0.01797174,0.002341743,0.020593453,-0.008704231,-0.04497913,0.01826583,0.023555776,0.081038915,0.051929943,-0.044791635,0.031278852,0.006811952,-0.07383322,0.09030243,0.043361224,-0.041374825,-0.0055355006,0.026658801,0.034711573,0.012833608,-0.13031283,-0.043550555,0.07309726,0.014528661,0.012996753,-0.07506648,-0.0024038104,-0.042397734,0.07200147,-0.031331006,-0.025087388,-0.038811218,0.008315734,0.030981978,-0.051939543,-0.032109976,0.06790647,0.009109059,0.041560844,0.09848813,-0.010304288,0.025969349,-0.036439523,-0.045538835,-0.032420587,-0.006813382,0.031010935,0.049220048,0.029098477,0.053226583,0.05583137,-0.082669094,0.08930648,0.061775625,-0.019266801,-0.0717349,-0.05118475,-0.04044551,0.0574209,-0.06709184,-0.050854765,0.046695855,0.026059259,-0.04057283,-0.012853919,-0.048482016,0.022005703,0.044085376,-0.021372916,-0.017689934,-0.0009115152,-0.019717135,-0.063691266,-0.08405529,0.028970711,-0.0089414045,-0.07059571,-0.052248266,-0.024142666,-0.024706453,0.025655482,-0.06000811,0.05021967,0.07669243,-5.6529575e-33,0.051680457,-0.06741075,0.047201976,-0.07119783,-0.10905911,0.07779995,0.041605968,-0.06926159,0.061094623,-0.024351032,0.029103799,-0.025289794,0.012073403,-0.09008303,0.014330677,-0.05702898,0.027146386,0.0782403,-0.04094631,-0.07584004,-0.005424358,0.107841544,0.014881716,0.05964369,0.009029483,0.003273289,0.027431611,0.0009099875,0.08624404,0.1353672,-0.014567947,0.070783824,-0.03564045,-0.046089172,-0.07876744,0.062571935,-0.022122223,-0.031241344,-0.017873941,0.037672658,-0.005081254,0.05438959,0.065896325,0.033593006,-0.06445841,0.037965693,-0.010521502,0.006440694,0.011029672,-0.08756941,0.078088626,-0.04487889,-0.03542338,-0.041720647,0.03043937,0.09466632,-0.057030875,-0.026798403,0.043350838,-0.12246287,-0.08539186,-0.018331336,0.06338124,-0.083601765,-0.037000537,0.04613858,-0.008514003,0.022457758,-0.012821547,0.029196808,0.0049395575,0.06919356,0.015706178,0.06710104,-0.007197884,0.09117638,-0.003670415,-0.02919044,0.05254573,-0.08556111,0.0171213,0.037859138,-0.042577233,-0.034979094,0.01817115,-0.115562335,-0.07329557,0.098793745,0.06221384,0.021715468,-0.029340668,-0.07402471,-0.08989158,0.013522016,-0.034739267,-4.3098723e-08,-0.005941551,-0.05707126,0.02973011,0.010740129,-0.02126373,0.09368624,-0.013355598,-0.08579234,0.054759186,-0.03252516,-0.016531961,0.092193484,0.006135881,-0.0010569508,-0.013124408,0.055135544,-0.022113413,0.00765998,-0.022235563,-0.037935853,-0.062307652,-0.05844468,-0.113935664,0.066310816,0.022729913,-0.059608873,-0.012721395,0.022882717,-0.038500056,-0.0077975076,0.011799932,-0.012850315,-0.01987096,-0.008718567,0.011681989,-0.02587978,-0.015837139,-0.037412595,-0.039864536,-0.0013547721,0.024653198,0.008189771,-0.01699958,-0.010113382,-0.009604845,-0.014187941,-0.0327615,0.079038404,-0.055653874,0.06254875,-0.02728761,-0.022365557,0.00016945768,-0.022355646,-0.015386257,0.025278246,0.052077264,-0.10962549,-0.082160145,-0.053080443,0.045224693,0.07582791,0.20223828,-0.036030967 +6.2.1.13,"Also acts on propanoate and, very slowly, on butanoate.",384,1.0,-0.0075150384,-0.102313265,0.019061882,0.08225178,0.02017288,0.013130588,0.0033532358,-0.04224955,-0.0005112276,0.02535634,0.06102982,-0.016541716,-0.08264147,0.06932723,-0.0403751,0.08123168,0.054101903,0.05203836,-0.008305993,0.030195532,0.074695654,0.007779755,-0.0206404,0.0197291,-0.008971622,0.034656107,-0.0586418,0.018916935,0.096740946,-0.10071047,-0.05225274,0.010110789,-0.012753901,-0.010895307,0.0073086172,0.06997866,-0.04132672,0.011289922,-0.007225362,0.003674406,0.06668675,-0.069264725,-0.03573422,-0.027420461,0.010404921,0.0021952784,-0.0030217182,0.006522242,0.037795126,-0.028314447,-0.06654548,-0.06908431,-0.047354497,-0.00838009,-0.07723014,0.0044775633,-0.06570678,0.035927977,0.05155089,-0.04149904,-0.02618091,0.014064123,-0.05191445,0.055082623,0.06715981,0.027935334,0.030137878,-0.026826682,0.05140111,-0.018011896,0.091826275,0.006696923,0.061537158,0.040606264,-0.017108224,-0.052960377,0.028207842,-0.047472946,-0.0018799898,-0.044121623,-0.01837978,0.0049934858,-0.035296895,-0.036638286,-0.00718203,0.025993109,0.0029688287,-0.08247098,-0.082819715,0.00020441898,0.035906315,0.012567373,-0.052560303,-0.04727234,0.020387242,0.0009747962,0.063781574,0.023537721,-0.014707205,-0.010918703,-0.06762473,0.027043525,-0.08912006,-0.031406123,0.016639858,-0.046958596,-0.024533968,-0.037187334,0.002001819,0.06353212,-0.02871595,0.00027701192,0.002098557,0.078269154,-0.009848341,0.027628627,-0.04185597,0.013025909,-0.042119827,0.062418867,0.033758085,-0.06090725,-0.03101837,0.018463302,-0.04597998,0.011394333,0.012019898,-1.5345639e-33,0.05430952,-0.07810618,-0.012941565,-0.0026349535,0.0037943756,-0.007773461,-0.026733797,-0.034153935,-0.0124044055,-0.041446444,0.014593923,-0.056262925,-0.03520202,0.077481955,-0.036543414,-0.121802524,0.049811408,0.010391927,-0.01803236,-0.043471754,-0.020056553,0.124932006,-0.08555014,-0.021581784,0.0016026008,-0.018885784,-0.046640895,-0.006331584,-0.012224698,0.0017813323,0.069046445,-0.02685876,-0.06507452,0.03285565,0.028891828,0.07025123,0.024353882,-0.047901705,-0.0181933,-0.015616077,-0.04545813,0.034855902,-0.113514625,-0.048237324,-0.005792591,-0.02064599,-0.032388102,0.09108397,0.040971745,-0.0044526057,0.10342286,0.007836711,0.06984646,-0.04772244,0.015220737,0.0525301,0.027632745,-0.03350157,-0.039659083,0.050990213,-0.018246135,0.028776282,0.0105427345,0.0240133,-0.015050701,0.012147945,-0.12763329,0.007130046,0.009016205,-0.0074523557,-0.07073821,-0.010868299,0.098039426,-0.0385548,-0.012668856,-0.04855071,-0.003826588,-0.001915994,-0.07023742,-0.006156947,0.0049231714,-0.06679045,-0.005235233,0.025078146,-0.029156342,0.04413601,-0.0054188,-0.06734778,-0.011519566,0.040855467,0.088555,-0.026455723,-0.002306511,-0.07025893,-0.006574457,-8.222764e-34,0.019934777,-0.09990013,0.02743731,0.13578032,-0.018267494,0.09355347,-0.05578227,0.035185788,-0.055228874,-0.030456884,0.0510544,-0.04321531,-0.031085478,-0.022877263,0.011999264,0.11939075,0.05994994,0.14003097,0.010357526,0.030742753,-0.019073501,0.08768649,-0.011168884,0.06641043,-0.01532277,0.036300983,-0.02983393,0.0069695064,-0.025946204,0.029007575,-0.011642864,0.00326714,-0.14996672,-0.10498185,-0.041971635,0.069928475,-0.05873823,-0.01524387,-0.08072425,-0.07728193,0.009664639,0.0030039018,0.054860007,0.0964431,0.042104926,0.013923323,0.050244264,-0.023769945,-0.059607577,0.069809176,0.033726364,-0.027858129,-0.057061568,0.051096402,0.0072505353,0.03655087,0.01608807,-0.10400834,-0.024115402,-0.020476768,0.04262406,-0.06977153,-0.033373103,-0.051364034,0.08782901,0.010547532,-0.031999458,0.021717573,0.14124636,-0.015656034,0.09187317,-0.04918999,-0.0066847713,0.026765604,-0.07653805,-0.029677536,0.011483124,-0.14219083,-0.069339626,-0.08961567,-0.0803254,-0.009649118,0.018680008,-0.006220569,-0.06465386,0.030016642,-0.049016982,-0.0015981474,-0.023164673,0.10805359,-0.022885673,0.0022988312,0.03202965,0.020765673,0.034933798,-2.161075e-08,0.021506228,-0.022077031,0.16513106,0.011271621,0.035233647,0.013028667,0.1456687,0.042241026,0.019764004,-0.07787674,-0.013229854,0.046898346,0.12935565,-0.0006350396,0.14368519,-3.1795018e-05,0.05534209,0.03855093,-0.0709579,-0.038694218,-0.09297763,-0.058125876,-0.014079071,0.010252204,-0.022987878,-0.015568146,0.01892593,0.14419706,0.031577673,-0.00481601,0.046571594,-0.038874574,0.0059265792,-0.037180636,-0.026712837,0.05421979,0.08895439,-0.004415458,-0.012795209,0.02452704,-0.056332666,-0.010029257,-0.027376246,0.07191409,-0.06533061,-0.026250929,0.02229614,-0.046691533,0.018892119,0.03864059,0.07112195,0.014056536,0.0078023975,-0.010495912,-0.024886437,0.0555798,0.024806105,0.015401042,0.03756136,0.009368337,0.023732081,-0.029703438,0.07749125,-0.019120198 +6.2.1.15,"Not identical with EC 6.2.1.3 long-chain-fatty-acid---CoA ligase. Icosa-8,11,14-trienoate, but not the other long-chain fatty acids, can act in place of arachidonate.",384,0.99999994,-0.105602585,-0.102559045,-0.031169161,-0.019387525,0.066420704,-0.03172687,-0.09232139,0.08645104,0.010744185,-0.05698496,0.090177685,-0.0501969,-0.11956886,0.016531961,0.02457276,-0.06269884,-0.04102889,0.031420436,-0.010746789,-0.0045808973,0.068609096,0.007539567,0.011070822,-0.00060342846,-0.033262763,0.045888927,0.15480952,-0.038705815,0.04173418,-0.08536152,-0.0032110722,-0.061697986,-0.005691656,-0.059944794,-0.0151792485,0.033710107,-0.024039371,-0.07930901,-0.0075674052,0.01765705,0.08741635,-0.026260199,0.04319763,-0.10881811,-0.033523228,-0.08332675,-0.047746826,-0.00083843304,-0.060904894,-0.007804972,-0.014916333,-0.092305824,-0.09804682,0.037137564,0.053929582,0.04124427,-0.111194216,-0.08384432,-0.066805124,0.13709389,0.057356253,0.03614162,-0.009123185,0.041447777,-0.060098354,-0.013355214,0.104658365,-0.057912905,0.00079627277,-0.0094056055,-0.0099791195,-0.07077395,-0.008969386,0.074627034,0.014993285,0.08283807,0.012147305,-0.065272175,0.016116636,-0.07214781,-0.06123829,-0.0044671316,0.050447688,0.03430559,-0.010324997,-0.022425199,-0.0034045386,-0.011827888,-0.050101146,0.063724205,0.09654218,0.030664563,0.027571846,-0.037631683,-0.05191124,0.0119164195,0.06552887,0.092412464,-0.022358831,-0.030771391,-0.02792725,0.11733989,-0.14302795,-0.05744109,0.0017439121,0.043720562,-0.039786667,0.010263738,0.0062836376,0.03574704,-0.037169114,-0.025906574,0.002205897,-0.02695315,-0.06429687,-0.002110739,-0.01358321,-0.049755108,0.04464749,0.109782554,-0.042374894,-0.064681105,0.03665567,0.049427424,0.020024205,-0.044664983,-0.01614959,-2.5281155e-33,0.06629033,0.008684721,0.011304531,-0.06854091,-0.01093627,-0.023449482,-0.08568318,0.050674718,-0.07243078,-0.033470303,0.015436366,-0.022653103,-0.008479457,0.0483186,0.027282346,0.0077094077,-0.007960982,0.07412814,0.025005877,-0.0310635,0.02491572,0.064528815,-0.018384157,-0.019041492,0.04659123,0.013798096,-0.02392588,0.029573793,-0.010003344,0.024030281,-0.07201249,-0.080830574,-0.032693505,0.05988868,-0.027714198,0.04220718,0.005353618,-0.07148724,-0.071952574,0.04294635,0.10082174,-0.0018926014,-0.033385765,0.015272994,-0.014157838,-0.061361514,-0.0054287664,0.03770675,0.06509216,0.036259755,0.005068632,0.010569989,0.045970786,0.02308171,-0.011225357,-0.02416418,-0.05299507,0.009060226,0.03203967,0.02190134,0.05842061,0.054399528,-0.04700239,0.044008963,-0.007696101,0.065836184,-0.10244998,-0.04701621,0.0076699764,-0.03349452,0.017277073,-0.038335778,0.07060324,0.050640084,0.06632063,-0.042377327,-0.104772806,0.035286885,0.007664547,0.044074837,0.009781075,0.034600463,0.084518366,0.013459078,-0.05917545,0.05948784,0.0038867623,0.010148061,0.0130574815,0.021981223,0.05647816,-0.035319015,0.0001619694,0.026460243,-0.0026982506,7.4578486e-34,0.02464826,-0.042087324,0.011374841,-0.082821295,-0.021862244,0.055108488,0.051900454,0.056978766,0.03278298,-0.05592601,0.13629629,-0.040358428,-0.017424267,-0.09107357,0.033364628,0.0009532847,0.0024092246,0.0030905597,0.05119537,0.014045889,0.043624304,-0.03766677,-0.026304377,0.06849262,0.022649473,0.030256951,-0.0012365774,0.038569838,0.027461296,0.07456908,0.046014685,-0.005539288,-0.012509291,-0.04511278,-0.071021155,0.04391436,-0.051899843,-0.0077549657,-0.052549493,-0.017633313,-0.034042753,-0.044659268,0.042767473,0.07683555,0.052997604,0.009029786,0.050889302,-0.034995962,0.00016861611,-0.056689676,-0.01512847,0.005720564,-0.04882987,0.059695024,-0.0010353457,0.047005873,-0.011283079,0.028519051,-0.007058992,-0.07301738,-0.0118536055,-0.036892477,0.004233155,-0.078955315,0.09204362,0.08088938,-0.011862198,-0.030612852,-0.009216865,-0.021142276,0.063159004,-0.002636093,-0.027159415,0.0121146785,-0.011439167,-0.07808092,0.038213074,-0.06332947,-0.042103156,-0.024188228,-0.015035773,0.008441464,-0.05515035,-0.0027666413,-0.04682078,0.016717667,0.053966198,0.036847077,-0.042218007,0.08521839,-0.050471727,0.037767194,-0.055186342,0.06378698,0.0474771,-3.0825063e-08,0.09647392,-0.061312653,-0.020703388,0.002054663,0.000871144,-0.0106985215,-0.058495577,-0.009488635,0.022710916,-0.008097505,-0.029569369,0.12179402,0.036747396,0.058359522,0.0034854584,-0.0490292,-0.00765147,0.01072536,-0.00663672,-0.054267563,-0.14225549,0.01808568,0.016009416,-0.10529535,-0.06559733,0.021670278,0.022615394,0.059862398,0.0038348387,0.027141452,-0.015695123,0.021060329,0.03828717,0.032355685,0.084303185,-0.00021955512,0.03138183,0.015484176,-0.053332306,0.05031854,0.06755593,-0.02406115,-0.0550928,0.08279532,0.105456546,0.0010060661,-0.0026329006,0.007415314,0.055611078,-0.021718623,0.02534396,0.020601664,-0.03820996,-0.103918076,-0.015461653,-0.05269557,-0.016107079,-0.07408332,-0.013709535,0.057437442,0.0644095,-0.05604398,0.15687051,0.037008148 +6.2.1.16,"Also acts, more slowly, on L-3-hydroxybutanoate.",384,0.99999994,-0.005652727,-0.17278147,0.05104045,-0.020449402,0.08282964,0.0059064473,-0.033524953,0.03643022,0.0026803014,-0.07775394,0.056247756,-0.010508876,-0.0038429168,0.07892816,0.023783516,0.06274397,-0.0047479733,-0.018141253,-0.04411224,0.004582133,0.04991549,-0.028404085,0.032660436,0.023349313,0.0060523385,0.020263625,-0.02613703,-0.0021462932,0.043625828,-0.1398137,-0.011674747,0.086220354,-0.03341292,-0.09498317,-0.04029058,0.06303303,-0.09205406,-0.01004956,0.02270965,0.06735789,0.060977694,-0.08421036,0.041855924,-0.057561338,-0.015399213,-0.004465264,-0.0015063917,-0.034933366,0.047113672,0.007384724,-0.03792643,-0.110966675,-0.021759838,0.035550572,-0.077928774,-0.039793864,-0.06149658,0.09959201,0.053044766,0.026114296,-0.043143798,0.120710656,0.008018724,0.061396893,0.068941474,0.0016747038,0.0032626453,-0.087054044,0.012323028,0.05198116,-0.008567785,0.012253098,-0.015671315,0.014524334,0.02023126,-0.052667797,-0.023012253,-0.016555829,-0.00018124164,0.0014884756,-0.03601627,-0.029443508,-0.062336892,0.092726424,-0.020833278,-0.03120742,-0.018676259,-0.09226491,-0.07841778,-0.00023978757,0.03176143,0.054961666,-0.08893365,0.05483303,0.0057584485,0.030961625,0.00018147341,0.008951722,-0.043238528,0.010575676,-0.033215985,0.051100057,-0.054549146,-0.029017972,0.016047383,-0.01667181,0.03474063,0.020509694,-0.050978545,0.03171877,-0.014512786,-0.03927501,0.023060052,0.04434906,-0.14277515,0.101248056,0.007808099,-0.03085952,-0.07740785,-0.055231392,0.05154135,-0.03571368,0.033218436,-0.038636968,-0.05476148,0.048133794,0.003704662,-5.6980954e-34,0.03919425,-0.060574323,-0.02773446,-0.0499954,0.006595226,-0.038499393,-0.10712844,0.018240143,0.010184831,-0.01793445,-0.038653728,-0.018682687,-0.03834041,0.04110374,-0.061989903,-0.108486705,0.008706071,0.019948479,-0.06649526,-0.015729116,0.058130167,0.014740261,-0.08750539,-0.008787709,-0.042568162,0.010547618,0.05926314,0.020526424,-0.02166552,0.019320177,0.018063713,-0.024128089,-0.045242425,0.013071589,0.010114896,0.06564016,-0.04992347,-0.06824904,0.030102696,-0.00889919,-0.0062045823,0.0651169,-0.025110308,-0.033372167,0.042916358,0.005585931,-0.047556367,0.07017757,0.02168346,0.047153927,0.1542894,-0.0012202375,0.008827081,-0.008675762,0.011440912,0.030041285,0.031800773,0.033193182,-0.033396453,0.05050683,-0.02088213,0.059553422,0.004754497,0.0118484525,-0.029810514,0.05309161,-0.06551118,0.015409845,-0.014062838,-0.045970954,-0.060225185,-0.024994444,0.13117395,0.03159057,0.05064389,-0.0550268,-0.027086204,-0.05561061,0.015293305,-0.062392794,0.03450657,-0.02798375,0.06971199,0.034653783,-0.08599935,-0.033011448,0.031378664,-0.07569434,0.006011472,0.02039833,0.048842996,-0.064695574,-0.009591602,-0.016076831,-0.023692181,-4.437585e-34,0.015118777,-0.0630039,0.05677262,0.043294806,0.016805744,0.04501451,0.0580633,0.06490888,0.032842744,-0.00018786055,0.06090415,0.032104228,-0.10825553,-0.040819123,0.083682634,0.06426485,0.07466406,-0.005797236,-0.0028046004,0.0023635158,0.056456592,0.051295668,0.03489209,0.13950448,0.012363943,0.032942843,0.041573532,-0.011578205,0.0073823184,0.026749432,-0.044821348,0.0025446606,-0.062960505,-0.08572635,-0.045342572,0.07025564,-0.030581037,-0.0029678014,-0.057071645,-0.06988821,-0.008337034,-0.06414054,0.06805856,0.03830184,0.009048808,0.045636557,-0.0015546371,-0.06885212,-0.025681198,0.09221874,-0.016123928,-0.016396856,-0.0068583786,0.049545616,0.041798472,0.057868313,-0.017128082,-0.087995574,-0.036873743,-0.026171215,0.00879542,0.025637878,-0.021592373,-0.03406952,0.045215398,0.019729694,-0.006936366,0.037648052,0.098018005,0.0008054923,0.12808837,0.003867369,0.036732934,0.018655913,-0.051271565,-0.089575134,0.0047895545,-0.085315265,-0.06661463,-0.050440617,0.010080507,0.06545538,0.01577415,-0.09564245,-0.054760538,-0.054366775,-0.09649331,0.062407725,0.00020428532,0.0642498,0.012159147,0.017646011,-0.056096,0.034849506,0.10669892,-2.2818167e-08,0.0015639487,-0.008719967,0.08452581,0.056813106,-0.015731301,0.028233353,0.036976025,0.106453046,0.017708195,-0.08123745,0.038498003,0.07773546,0.04816326,-0.00841653,0.078381136,-0.037262306,-0.021189565,0.04366891,-0.08201756,0.018769559,-0.117041014,-0.018290829,-0.008615497,-0.044357065,-0.040445924,-0.019315531,0.0078801615,0.104754925,0.019925145,-0.011049328,0.0537101,0.037036136,0.0024062719,-0.010286911,-0.06163852,0.065017134,-0.026258808,0.01491793,-0.017519277,0.04794187,-0.05629862,0.011097399,-0.0114228865,0.03155004,-0.020863324,-0.05669684,-0.04205121,-0.0035628837,0.052684113,-0.0011283654,0.08161944,-0.03305499,-0.040536363,0.0044275206,-0.01757286,0.030654773,-0.054067608,-0.028182484,0.040964194,-0.05541387,-0.04850276,-0.04609408,0.15413488,0.06576758 +6.2.1.17,Propenoate can act instead of propanoate. Not identical with EC 6.2.1.1 (acetate---CoA ligase) or EC 6.2.1.2 (butyrate---CoA ligase).,384,0.99999994,-0.06504671,-0.08651316,-0.017892106,-0.031156663,0.026391827,0.057059377,-0.07625852,0.031053672,-0.013444483,-0.009332458,0.061683316,-0.034908686,-0.14232384,-0.045068923,0.06179441,0.04502934,0.018923702,-0.009451229,-0.009552107,0.033903044,0.016607692,-0.051316332,-0.022353645,0.037799068,0.07612319,0.035286963,0.019013673,0.07494472,0.061016817,-0.065232106,0.008388337,0.007170272,-0.09319367,0.0048633865,0.001916102,-0.032973755,-0.04237698,-0.09835714,-0.086375386,0.018990366,0.061304167,-0.09102031,-0.030140474,-0.015970185,0.055684,-0.044599004,0.013814454,0.07176671,0.007116761,-0.061293278,-0.04666702,-0.10925572,-0.01761764,-0.0055057853,-0.004947367,0.076510645,-0.019439412,-0.0063596144,0.054506343,-0.010797856,-0.0002950656,0.015188683,-0.044453196,0.0013976528,-0.043633316,-0.012226098,0.08314956,-0.03658628,0.04372688,-0.036201436,0.0013905598,-0.09233036,0.067809455,0.09222345,0.013848736,0.07964815,-0.0009852668,-0.032629758,0.06543661,-0.026517535,-0.03406588,-0.032142002,-0.06886324,-0.0753808,0.0057206303,0.024091074,0.011851272,-0.007950074,-0.029625393,0.0070505245,0.026378866,0.013592719,0.08144973,-0.043998472,-0.07120346,0.037124455,0.05823035,0.08611873,0.07422402,-0.018169584,-0.030353893,0.117975496,-0.11391351,-0.01972783,-0.043251406,-0.0129474895,-0.03110298,0.09480088,-0.003981384,0.053414855,-0.033102036,-0.07050132,0.0349126,0.032919794,-0.044767722,0.03096107,-0.04324833,-0.051113095,0.051954575,0.09577517,0.044804137,-0.032251697,0.016370155,0.044465024,-0.012925871,-0.010534767,-0.03588471,-1.7591396e-33,0.07206636,0.038524378,0.06428955,-0.007914022,2.6081587e-05,0.06533767,-0.09546477,0.022601234,-0.052857526,-0.11430542,-0.008525803,-0.022142434,-0.032531988,0.03466601,0.009958913,-0.06133693,0.023254445,0.09754029,0.013936206,0.023301996,-0.0001440372,0.02693741,-0.05696208,-0.022773264,-0.0442243,-0.0032221195,-0.044064417,0.08432721,0.02286959,0.030280156,-0.037635677,-0.09802846,0.025987387,-0.0077143568,-0.058131743,-0.05101934,-0.018078545,-0.124199994,-0.060306158,0.00808022,0.029385421,0.053755224,0.005956608,0.016844615,0.023815563,-0.067715235,0.028842317,0.0470736,0.011397888,-0.037767846,-0.002229235,-0.03602191,0.086545564,-0.053307936,0.057736102,0.023164494,-0.04622019,0.05514229,0.015977675,-0.034351304,-0.034460366,0.111310065,0.0034701535,0.040968914,-0.015996266,0.069365256,-0.04751555,0.0013690068,-0.008198688,-0.0042649494,-0.03666568,0.0533045,0.015431438,-0.012082131,0.080735326,-0.08315544,-0.021291727,0.016503477,-0.03731232,-0.056170043,-0.08774303,0.04476674,-0.0063669723,0.10064707,-0.024690691,0.023056451,-0.020498436,0.071976215,0.02167526,0.024647303,0.10989847,-0.04565642,-0.027620204,0.008843781,0.029517937,1.1070431e-33,-0.02740398,-0.06877306,-0.009512358,0.014626544,0.0030730674,0.08029261,0.07534912,-0.054957937,0.003996155,-0.09720595,0.12854002,-0.05603048,0.050471533,-0.12174641,-0.024280174,-0.01231977,-0.0009502629,-0.006392997,0.046332736,0.056758877,0.031812757,-0.04886503,-0.017994674,0.049187098,0.0007916413,-0.04468201,-0.00073745544,-0.003472634,0.021023158,0.047355466,0.03232472,0.019997664,-0.072413474,-0.04876098,-0.0014014785,0.009325433,-0.036058675,-0.0035070768,0.025184652,-0.06763545,-0.07913293,0.025314616,-0.028208539,0.024846572,0.026802678,0.021588601,0.09572971,-0.026925059,0.0486725,-0.010061303,-0.021211663,-0.04014833,-0.092242286,0.06262472,-0.01775259,0.0048036096,0.045557626,-0.0048494134,-0.004889238,-0.019644544,0.013860203,-0.04020303,0.015141728,-0.064872056,0.09495346,0.061165776,-0.06750717,0.08765392,0.039499603,-0.027991125,0.121581845,-0.019473469,-0.01683338,0.04363779,0.022565246,-0.083141804,0.009436441,-0.044146977,-0.04981639,-0.014617405,-0.05443749,-0.0062676654,-0.04088628,0.022086047,0.031227535,0.025740152,0.03422791,0.042469975,-0.0233079,0.100503564,-0.048416898,0.006713086,-0.06393277,0.096939,0.038267832,-3.4717097e-08,0.07157937,-0.0701484,0.097980805,0.0011079721,0.03679178,-0.05734064,-0.018497951,-0.01794842,0.053524792,-0.033084802,-0.0943345,0.030023905,0.08288095,-0.025117086,0.061115127,-0.035127785,0.052995607,0.030275242,-0.06261898,-0.016771171,-0.042498898,-0.061287254,-0.07547905,-0.04480169,0.012456636,-0.029798103,0.001857137,0.082834125,0.019160254,-0.024250118,0.037366923,-0.022386016,0.025708122,0.010720623,-0.020651435,0.024607178,0.09653657,0.031330016,-0.050656904,0.04051755,0.03281296,-0.12121622,-0.07118668,0.040731803,0.05071051,0.024603644,0.080449454,-0.014559795,-0.019483974,0.0007935477,0.068058625,-0.054679513,-0.012539855,-0.07772676,0.0062021795,-0.016432751,0.034650102,-0.0039635776,0.065875776,0.006400325,0.09572413,-0.0029008563,0.14531527,0.016527457 +6.2.1.18,The enzyme is a component of EC 2.3.3.8 ATP citrate synthase.,384,1.0,-0.05850416,-0.0016494027,-0.04002323,-0.03973467,0.03648977,0.0063503725,-0.07441586,0.041926287,0.06797162,-0.027079575,0.066474214,-0.1235395,-0.050402198,-0.024112739,0.0049557765,-0.056280527,-0.049557786,0.011276281,0.002489281,-0.11374812,0.08087484,0.05865063,0.02019177,0.0024173262,-0.00088149065,0.038390964,0.08347518,-0.013572717,0.0062141796,-0.06488528,-0.07524725,-0.048954964,0.019759052,-0.053335115,0.024364704,0.06305177,-0.08950389,-0.11123828,0.043816984,0.027757347,0.097178146,0.04409228,0.0044874162,-0.009375347,-0.038284346,-0.02987181,0.04057676,-0.0003860668,0.019733757,-0.014805566,-0.03776643,-0.10444885,-0.004790288,0.008844726,0.03612728,0.009164157,-0.075011194,0.02702044,-0.006501925,-0.0058753537,0.056861646,0.0376231,0.040673357,0.01719052,0.051575754,-0.07711574,0.06315443,-0.038742073,-0.014686782,-0.037287448,-0.08605476,-0.07290848,-0.0026075707,0.044958457,0.031199804,0.059274986,0.006365248,-0.043938797,0.019137723,0.009724295,0.039483182,-0.008391916,-0.026609499,0.007255453,0.059210055,-0.04760806,0.042756237,0.019133072,-0.023250986,0.0063947607,0.017307589,-0.028454635,-0.031278834,0.022839911,-0.001022255,0.09261546,-0.025280299,0.08449155,0.015468445,-0.034004416,0.04741066,0.14369763,0.0074809385,-0.032955747,-0.025738498,0.014437617,0.0076731085,0.07477104,-0.015405164,0.05722473,-0.0076342993,-0.044039007,0.0076896264,-0.02903908,0.037798468,0.13149825,-0.0055194674,-0.027802248,0.069696516,0.031486683,0.037370536,-0.044307783,0.0065718056,0.06129142,-0.07215228,0.031214146,-0.08762156,-2.1659929e-33,-0.01026619,0.02421436,0.022563508,0.012229673,-0.023717416,-0.0025397881,-0.08095788,0.023518294,-0.10965866,-0.07884414,-0.055802613,-0.058192436,0.054911096,0.023067487,-0.0069322987,-0.08935445,-0.017766686,0.03230543,0.069813855,-0.025937643,0.04380419,-0.025241114,-0.036360506,0.00096711866,0.023608174,0.052166633,-0.041245423,-0.012030832,0.0429956,-0.01998666,-0.0171426,-0.05603918,-0.04673163,0.009321289,-0.0075067035,-0.030302221,-0.040069114,-0.018983386,-0.023666417,0.07967782,0.0020004648,0.013396915,0.057164628,-0.06788626,0.05168215,-0.06692109,-0.07327379,0.0698118,0.10795807,0.04116955,0.051601004,-0.03925139,0.12703022,-0.032589894,-0.017970722,0.014796466,-0.0196313,0.041910682,0.018823124,-0.002390156,-0.005569332,0.11636091,-0.050157834,0.024315363,-0.009576079,0.09171315,-0.15412557,-0.06263146,0.020312592,0.071732484,-0.08227802,-0.018505195,0.041210018,0.008557115,0.055615827,-0.053189427,-0.13558191,0.016478559,-0.024552392,0.048993003,-0.017312475,-0.009594349,-0.009870174,0.012616921,-0.05122449,-0.066774786,-0.021950815,0.018558608,0.016122093,0.057185784,0.0744849,-0.0043795696,-0.10419389,0.0679104,-0.00018865154,-9.509756e-35,0.0628717,-0.036009505,0.06784915,-0.09357942,-0.056692626,0.04708797,0.015505844,-0.03361436,0.03755078,0.0035355927,0.075187035,-0.04451242,0.0113035925,-0.09729774,0.03715381,0.0022297495,-0.07883259,0.04340272,0.03919295,0.018623168,0.063475065,0.032516573,0.033107083,0.060385548,-0.0006747835,-0.0050251833,0.041844655,0.062203564,0.045268968,-0.006550478,-0.046664618,-0.023931377,-0.062702194,0.016934453,-0.11397394,-0.013533444,-0.024467112,-0.03011452,0.00521944,-0.011234763,0.066570714,0.11456247,0.02690656,0.09046062,0.052035358,0.09791939,0.075695276,0.031699225,-0.06306703,-0.039750602,-0.0022651572,-0.0014305251,-0.02413953,0.04948172,0.05373161,0.074115306,-0.045129403,0.0336675,0.06130159,-0.041461114,-0.034708194,-0.04936839,0.03407887,-0.04193904,0.07155189,-0.015153494,-0.09977375,0.102527164,0.007456536,0.04819008,0.08198105,0.012958841,-0.061461546,-0.046629462,0.0055903266,-0.031124149,-0.07125712,0.010983334,0.022941569,-0.07903958,-0.013500904,0.03211245,-0.013961491,-0.06202592,0.009794318,-0.030095758,-0.011788848,0.08858721,0.025921067,0.017116599,-0.047495812,-0.009732715,-0.088565975,0.054258067,0.007160637,-2.3344397e-08,0.027194276,-0.027884854,0.03908546,-0.033133533,0.05348542,0.066126436,0.038274158,0.03817643,0.055661883,0.024851918,-0.012883699,-0.014938939,0.046188515,-0.050999045,0.028175768,0.068628244,-0.050749775,0.058071226,0.024439873,-0.01659295,-0.019068299,-0.028611481,-0.09107062,0.047214206,0.028949207,-0.019888733,0.024943518,0.06697701,-0.06005021,-0.033897527,-0.029231273,-0.0010646952,0.044567753,-0.06405231,-0.08394063,0.018047791,-0.020544162,-0.020755779,-0.07894978,-0.013890146,-0.017211575,-0.08039333,-0.056545977,-0.010960628,0.035619035,0.02508884,0.029614305,0.033855166,-0.02467055,-0.09861886,-0.0067387386,-0.0608816,0.0049587134,-0.055394214,-0.050308153,-0.06575462,-0.050085593,-0.062048394,-0.028600426,-0.059220076,0.044096388,0.013388057,0.15708812,0.008717084 +6.2.1.19,"Together with a hydrolase component (EC 3.1.2.2/EC 3.1.2.14) and a reductase component (EC 1.2.1.50), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme activates free long-chain fatty acids, generated by the action of the transferase component, forming a fatty acyl-AMP intermediate, followed by the transfer of the acyl group to an internal L-cysteine residue. It then transfers the acyl group to EC 1.2.1.50, long-chain acyl-protein thioester reductase.",384,0.99999994,-0.06459352,-0.049900174,-0.12012216,0.029376104,0.109273955,0.038509157,-0.105133146,0.0047607925,-0.0023745748,-0.09261734,0.028217789,-0.11477402,-0.02698256,0.0078048194,-0.011027061,-0.028424485,-0.081449546,-0.0018219993,-0.028804734,-0.09192246,0.06001333,0.034540433,-0.061629605,-0.011451449,-0.008812303,-0.033438373,0.021468233,-0.023535796,-0.07471322,-0.099916495,-0.001930014,-0.083228335,0.076705925,-0.045450743,0.0432028,0.055742573,-0.025604652,-0.05785171,0.053046808,0.024414113,0.025886966,-0.040857885,0.04883723,0.027667489,-0.053910967,-0.007269875,-0.0030275926,0.06391692,0.07129422,-0.044956204,-0.04237978,-0.024243232,-0.008576422,0.117613085,-0.05437118,0.011411591,-0.024198646,-0.059391145,-0.074518785,0.019518597,0.042258747,0.020511715,-0.020977862,0.017804379,-0.020009916,-0.066839255,0.0218861,-0.08460216,-0.008287054,-0.012832016,-0.07261762,-0.071687005,-0.07324714,0.044836286,0.057439573,0.004679426,0.0009595025,-0.0039863284,0.03326779,-0.007764795,0.03507322,0.003450732,0.05730522,0.059448652,0.02447782,-0.06830323,0.010741866,0.022808531,-0.034040324,0.08010443,0.048624124,-0.053021833,-0.076858625,0.003863333,-0.06202082,0.01875504,-0.01918347,0.039929915,0.054683745,-0.028571067,-0.047769364,0.011116841,0.028327974,-0.03364403,-0.08362253,0.0075637796,-0.008507412,0.118157245,-0.0088174725,0.02758675,0.06574374,0.0058729425,0.033876736,-0.008963696,-0.020108962,0.0672524,-0.026161097,-0.05856541,-0.1078786,0.018826945,0.03592014,0.004341983,0.10265976,0.08281363,-0.033350274,-0.05524401,-0.1470756,1.1285635e-33,-0.00033037632,0.0493148,-0.05494628,-0.029088642,0.023956671,-0.02971224,-0.08810499,0.07712429,-0.03183174,0.00831816,0.04374599,-0.020903947,0.05482722,0.04504356,-0.03181004,-0.06254129,0.0067071426,0.008770885,0.037575725,0.0076402933,0.027153116,0.053401858,0.033924405,-0.006576016,0.020149635,0.027444169,-0.021240715,0.04278414,-0.005154639,0.02387626,-0.04000966,-0.09604252,-0.03706328,0.018230665,0.055814,-0.010468862,-0.02156661,-0.044808034,0.03428928,0.018977636,0.07884492,0.048357874,0.032890968,-0.031544115,0.014003083,-0.0371219,-0.109753065,0.12287652,0.044832315,0.11114404,0.027951334,-0.043615185,0.093022384,-0.04060114,-0.049400046,0.03264694,-0.06395364,0.04491242,-0.006848884,-0.041554943,0.027238175,0.09384527,-0.07043037,0.0493223,-0.06207349,0.018606981,-0.020537853,-0.025119105,0.009871452,0.07045667,-0.042721402,0.058446955,0.07751372,0.009866461,0.027816106,-0.07812539,-0.09869167,-0.04425431,0.00694965,4.363155e-05,-0.030636583,0.00897246,0.049634505,-0.034554046,-0.026283843,-0.05460511,-0.05966903,0.020104246,0.013089706,-0.018208668,0.003562615,-0.055245895,-0.0073976433,0.04760939,0.03750431,-2.7499331e-33,0.15016459,-0.14119004,0.0811209,-0.10673254,-0.0040749577,0.023206186,0.016312178,0.071277596,0.0056064534,0.014031027,0.061070025,0.037643723,-0.053150497,-0.030630458,0.047049075,-0.02630339,0.010773337,0.050927274,-0.038320072,-0.071811736,0.010432816,0.0018646143,0.016275954,0.10365755,-0.051097013,0.007370857,-6.387757e-05,0.10945964,0.0047709765,0.055368435,-0.02237258,-0.022950673,-0.015948394,-0.07360992,-0.038337428,0.06967337,-0.071679786,0.01860566,0.027000926,0.046344575,0.103912435,-0.0004875046,-0.013125686,-0.037715476,0.041433092,0.076469384,-0.036047075,0.039820004,0.03927248,-0.1444752,0.041199565,-0.0153875835,0.0064489916,0.034391377,-0.05140868,0.05817537,0.026110694,0.034955084,0.04709809,-0.053388353,-0.036103003,-0.09311836,0.0033760744,0.007236293,0.032443278,-0.009156254,0.013169375,0.007010822,0.07898995,0.11809811,0.044961512,0.027774774,-0.020852827,0.0811382,-0.00854057,-0.06717124,-0.015580683,-0.054156408,0.016144073,-0.014589842,0.03340595,-0.0438968,-0.021455398,-0.034985904,0.046775967,-0.044121947,0.017341856,0.06677898,-0.048482545,-0.0035206939,-0.011566281,0.037639223,0.010948662,0.018636122,0.05096293,-4.3140904e-08,0.073187865,-0.05443781,0.033551637,0.024023503,0.04402679,0.08086846,0.0072344122,0.002875116,0.021620255,-0.03449455,-0.042137057,0.07639844,0.037958186,0.005246436,-0.0094264755,0.025017247,-0.06608365,0.044439066,-0.0024065108,-0.053581078,-0.017384412,0.0030351968,-0.054906778,0.016564356,-0.03554431,-0.024828237,-0.013586693,0.031952143,-0.0052583776,0.011271945,0.005211413,0.047158197,-0.011141943,0.023060078,-0.0527091,-0.0134535385,-0.038258966,-0.05653092,-0.025524864,0.029103387,0.080513984,0.034674224,-0.08193562,-0.015549603,0.039116956,-0.024382118,-0.038544215,0.015257442,-0.025937097,0.022968624,0.05658722,0.026781123,-0.051457014,0.009255407,-0.09905228,-0.033300366,-0.05168903,-0.08818246,0.0038375615,-0.016072804,0.090647325,-0.00798565,0.16889817,0.009035627 +6.2.1.20,The enzyme ligates long chain fatty acids (with aliphatic chain of 13-22 carbons) to an acyl-carrier protein. Not identical with EC 6.2.1.3 long-chain-fatty-acid---CoA ligase.,384,0.99999994,-0.050814666,-0.05050206,-0.02872166,0.015933495,0.02347433,0.04829614,-0.12266349,0.031223249,0.03446385,-0.09136018,0.13208778,-0.081363425,-0.05955874,0.017127624,0.038293995,-0.04138305,-0.06160611,-0.023827653,-0.043653745,-0.081854664,-0.008853684,0.013082657,-0.024955176,0.02699706,0.00069017767,-0.0858896,0.05214979,-0.052307297,0.0147406785,-0.10466866,-0.0010158146,-0.11142455,-0.017199315,0.0117047625,0.012750659,0.024732675,0.0058159544,-0.09857069,0.054008666,-0.0028802096,0.06960685,-0.043220323,0.0073460797,-0.020881098,-0.0045237592,-0.05606136,-0.042135276,0.049451385,-0.00018600257,0.053405076,-0.022805443,-0.067919455,-0.045162573,0.038166482,0.025635932,0.07645036,-0.09886629,-0.011018595,-0.039538015,0.055948142,0.02363183,0.024840381,-0.03141235,0.042551283,-0.068662256,-0.08791428,0.09520025,-0.04449202,0.018988866,-0.0071539953,-0.056595776,-0.12201805,-0.03536195,0.058830906,0.04581197,0.06332188,-0.06033247,-0.08088809,0.04412296,-0.00699531,-0.057739146,-0.027461728,0.015230835,0.061284542,0.01608051,-0.044307135,0.009089808,-0.013551018,-0.10295366,0.040877618,0.0479154,-0.06368695,0.0422496,-0.029225226,-0.075133756,0.04366973,0.028051993,0.05265764,-0.0014065439,-0.030336676,0.008014591,0.10285726,-0.06475912,-0.058006674,-0.06433485,0.016513221,-0.06800637,0.09814494,-0.0076390994,-0.018697558,0.0001977861,-0.012326145,0.04569043,-0.01596845,-0.006768774,0.06714837,-0.046580236,-0.051859215,0.052591722,0.06531176,-0.018756026,-0.027883664,0.002069479,0.08168132,0.012829412,-0.018883748,-0.058729067,-2.2518918e-33,0.037404664,-0.016064027,0.027177123,-0.01764526,-0.0015575101,-0.02245413,-0.103272095,0.090165555,-0.09262363,0.009655758,0.0059557646,-0.023060355,0.037600078,0.0380763,0.059324563,-0.060718983,0.015277419,0.042667225,0.03836984,0.0084073655,-0.020017346,0.061968144,0.04146279,-0.039523188,0.103204586,-0.017644266,-0.04055621,0.043368336,0.015993966,0.039076835,-0.09013737,-0.042859107,-0.041317537,0.054723885,-0.0066478522,-0.030183045,0.010125469,-0.066762954,-0.05843398,0.032885034,0.09595445,0.015595565,-0.025160383,-0.043526344,-0.012298362,-0.009199512,-0.018197566,0.036331892,0.036578994,0.046411745,0.049951844,-0.027397148,0.07131963,0.0033766394,-0.0054063,0.042782314,-0.08588163,0.03392291,-0.026526833,-0.0030513387,0.027884308,0.085718356,-0.05281958,0.06543577,-0.01112558,0.041097503,-0.08747923,-0.010311734,-0.023077387,0.057235774,-0.0054676724,0.04090031,0.030811893,0.0048661823,0.03901152,-0.06727592,-0.12963921,0.053537417,0.015659528,0.042529996,-7.4087284e-06,0.012490631,0.06524506,-0.00436599,-0.039952684,-0.03263906,-0.010540878,0.03221274,0.06305325,0.020499267,0.03581037,-0.013184143,0.014073607,0.066102885,0.02701248,1.8426371e-34,0.079169765,-0.114610165,0.051760428,-0.10744297,-0.03619375,0.021280454,0.08763777,0.032892194,0.018749267,-0.03977458,0.124851115,0.02334158,-0.0284091,-0.08576406,0.0718415,-0.0046559772,-0.04870949,0.0061833137,0.05451289,0.017260155,-0.00832032,-0.06559647,-0.04241831,0.06895624,0.060541313,0.04054842,-0.03240759,0.055925515,0.037607048,0.042042844,-0.009333463,-0.00045097113,0.012961809,-0.038552243,-0.096192025,0.04021519,-0.059007548,0.062222775,0.019086074,-0.0075916494,0.0021585359,-0.0041570156,-0.00034123237,-0.008348096,0.06694385,0.02381355,0.024838658,-0.046454657,0.0221442,-0.091209814,0.030829191,-0.01477323,0.032871652,0.031485587,-0.018431135,0.06681945,-0.014200802,0.052486718,0.07236523,-0.10867874,-0.059812248,-0.031211017,0.018754221,-0.02178859,0.045192007,0.018611232,-0.030173725,-0.049682967,-0.0014380096,0.0005766736,0.052737262,0.044986784,-0.027486175,0.03086616,-0.0023590499,-0.075214654,-0.044367705,-0.037135884,-0.05879239,0.009032315,-0.016519824,-0.025652701,-0.055747587,-0.009022837,0.015279193,-0.0055164476,0.044371255,0.04987207,0.0117484955,0.08965791,-0.031923067,0.013176749,-0.023662737,0.036828432,0.043551434,-3.1028343e-08,0.08712041,-0.072467916,-0.020707449,-0.03300353,-0.0046728193,0.0639957,-0.016729487,-0.018924782,-0.01318775,0.0033565105,-0.022196038,0.081747286,0.030718606,0.049342208,-0.022759242,-0.0645838,-0.052361652,0.0033027295,0.0411674,-0.0097237555,-0.09384616,0.015642835,-0.008629892,0.04654999,-0.051747844,-0.010174147,0.014696727,0.04297081,0.014178097,-0.00074868766,-0.017950311,0.018503081,0.01789328,-0.0010898457,0.012920781,0.00088506227,0.046669796,-0.047240164,-0.052348997,0.13538258,0.08907051,0.0007631841,-0.076160185,0.0077547766,0.11467667,-0.012897337,0.03839474,0.037331738,-0.014679508,0.03850871,0.046723835,-0.004241279,-0.085832,-0.05718938,-0.02462331,-0.089929186,-0.015075024,-0.1164848,-0.02998844,0.01024301,0.06849409,0.0055343187,0.23063052,-0.050987218 +6.2.1.22,"Both this enzyme and EC 2.3.1.49,deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase, acetylate and activate EC 4.1.3.6, citrate (pro-3S)-lyase.",384,1.0,-0.06108117,-0.05227961,-0.11523995,-0.01230905,0.0936019,0.029288415,-0.009620274,0.025503956,0.01618155,-0.025597636,0.0950781,-0.07618235,-0.057760905,-0.044903953,0.052712135,0.042103,-0.06334049,0.017421898,-0.022986699,-0.12666012,0.050803795,0.011553636,-0.04167082,0.019192228,0.04739328,-0.014824551,0.023673682,-0.018298805,-0.035548046,-0.13444781,-0.037972745,-0.08776283,0.0468857,-0.06550047,0.016886426,0.0069698975,-0.06657675,-0.11597704,-0.00730095,0.041626953,0.04856063,-0.027597664,-0.034048393,-0.07181696,-0.036649033,-0.021572698,-0.054888707,0.025313687,0.057955623,-0.0030099836,-0.012371886,-0.0630196,0.015027241,0.047291912,-0.04841543,0.025512844,-0.045844242,-0.026243566,-0.0089266915,0.022795755,0.034977235,0.047578294,-0.00290158,0.01908273,-0.03332174,-0.034833446,0.115163475,-0.10903453,-0.0059857382,-0.017498776,-0.08611806,-0.12158125,0.003939992,0.07504262,0.051156316,-0.0070613404,-0.017630465,-0.047677327,-0.0033474758,-0.010659998,0.048230402,-0.0055719637,0.01256361,0.026531648,-0.011645929,-0.024538677,-0.084800445,0.011221503,0.016403243,0.008160419,0.051997047,-0.032697212,-0.043624476,0.019248672,-0.032942217,0.032272942,0.013417465,0.0659719,-0.0038184337,0.0019742472,-0.0111142285,0.10945734,-0.04516976,-0.096711084,-0.038089503,0.024148779,0.019146727,0.07129756,0.010798437,0.020952452,0.02880456,-0.114005715,0.03326903,-0.0044165235,-0.057864275,0.15302135,-0.003922008,-0.04515075,0.07480717,0.01001467,0.08647264,-0.017517693,0.06297015,0.053760935,-0.06087239,0.06726153,-0.051772997,2.3513958e-34,0.0023336727,0.030698098,0.019196492,0.05625002,0.011325043,-0.00030722926,-0.10270824,0.015322479,-0.025042001,-0.100566454,-0.101996556,-0.051890574,0.0050960425,0.005815289,0.00095523207,-0.018110871,0.03005471,-0.033203103,0.06256661,0.031660914,0.07921129,0.048855744,-0.073652335,0.0247882,0.040953778,0.05135825,0.014187217,0.035478547,0.029415438,0.016313786,-0.0010225001,-0.034698665,-0.018279387,-0.0043304097,-0.012298576,0.036819495,0.006817269,-0.06514001,0.0066170865,0.07647238,0.060405213,0.036895443,0.04000374,-0.047475807,0.043799195,-0.035625186,-0.048380893,0.07741686,0.083990544,0.08444626,0.024073321,-0.043520045,0.06838788,-0.028861342,-0.040258635,0.014547519,-0.056120012,0.047145218,0.06079427,0.034680307,-0.0281233,0.041694596,-0.00068458595,-0.01776386,0.010826659,0.046367727,-0.1020926,-0.041792877,-0.04689662,0.013360608,-0.12179777,0.0007609061,0.10796832,0.03348655,0.078405306,-0.094349906,-0.10260107,0.022903025,0.0030656308,0.044159904,-0.032158855,0.012002502,-0.005600918,0.057576988,0.01353252,-0.07381683,-0.048060983,0.03180914,0.010856772,0.027221343,0.020930046,0.037838556,-0.041556273,0.0892722,0.0322417,-2.8814559e-33,0.05757956,-0.06591169,0.04026102,0.0029392627,-0.031459644,0.11215411,0.014567255,-0.0050273705,0.015074949,0.027087864,0.14057592,-0.0062300595,-0.029371288,-0.099793926,0.067789145,-0.04027565,-0.07149364,0.015226707,-0.045381974,0.06283484,0.0211893,-0.009430488,0.027904892,0.040559396,0.07372612,-0.016893663,0.03259662,0.0350431,0.06419336,0.014966543,-0.028598586,-0.010268854,-0.06206494,-0.010436221,-0.120269895,0.029788414,-0.040910956,0.012795886,-0.04878523,0.019790113,-0.021240486,0.060548898,-0.004760505,0.04837901,-0.008567724,0.09160031,-0.005232599,0.014277531,0.01961478,-0.083686344,-0.004586993,0.0077710673,-0.074677944,0.02972448,-0.01520675,0.05325076,0.025099097,0.027796311,-0.029122854,0.0049675116,-0.07455533,-0.030475141,0.019682307,-0.025991708,0.072626546,-0.0038743564,-0.028451351,0.10501257,0.07841266,-0.018438388,0.053121645,-0.009781611,-0.010689069,-0.05785068,0.00095757126,-0.056827687,-0.099169046,-0.07579991,0.0011237012,-0.099996895,0.028519923,-0.08319187,-0.015176293,-0.042472966,-0.00911809,-0.0184291,-0.016823119,0.06392503,-0.03339391,0.04319538,-0.044875246,-0.009285664,-0.055189993,0.029456899,0.009902056,-3.451267e-08,0.04784287,0.0023330825,0.03311641,-0.040191036,0.01420626,0.035076585,-0.007578384,0.060598828,0.0059290975,-0.027996896,-0.041221227,0.04955269,0.028056374,-0.021667337,0.06521252,0.040231865,0.05581385,0.144278,0.033063795,0.049596,-0.039826933,-0.054901086,-0.08160893,-0.007225457,0.0038991582,-0.005113633,0.07995941,0.11657812,0.03328672,-0.03268057,-0.06517217,-0.019157799,-0.008775095,-0.0021884874,-0.021937562,-0.027555797,-0.06332903,-0.04202704,-0.039591923,0.023683101,0.011279958,-0.0043037683,-0.09762964,0.01984742,-0.020197596,-0.01363416,0.07274193,0.019811662,-0.03455267,-0.056742724,0.012482877,-0.103706144,-0.008753927,-0.02054058,-0.0419648,0.0044021606,-0.02768051,-0.056137886,-0.011602141,-0.033251338,0.06799336,-0.0028289955,0.128729,0.01982064 +6.2.1.23,Acts on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid.,384,1.0,-0.026248815,-0.04829144,0.001824694,-0.04845976,0.03689372,0.03476747,-0.064922124,0.05035878,0.010864743,-0.03933767,0.020056626,-0.04611498,-0.079945564,0.04590888,-0.028920755,0.051913943,-0.019510556,0.06345164,-0.036187477,-0.02399626,-0.00033918585,-0.030419968,-0.022717476,0.019703489,-0.07374507,-0.015309989,0.05982461,0.03173514,-0.032585707,-0.15270562,-0.017263768,0.013698218,0.007785849,-0.002384187,-0.049645785,0.08839165,-0.07625437,-0.0594201,0.14981042,-0.007349696,0.069649585,0.010794239,0.05677713,0.00077486766,-0.012369431,-0.061268065,-0.0062912633,0.03919158,0.031003611,0.020646574,-0.01329253,0.0054332116,-0.038551975,0.030920465,-0.057107452,-0.04670111,-0.104855984,0.042979002,0.048570886,-0.008031189,0.04065794,0.01731493,-0.0019777117,0.028564885,-0.07457197,-0.0024934981,0.023582542,0.0012019604,0.023109363,0.029917637,-0.11357482,-0.042854574,-0.002457502,0.004272276,0.062324777,0.027840763,-0.039797686,-0.12498207,0.064369746,-0.041699808,-0.039197847,0.11747537,-0.014976572,0.08283489,0.023844332,0.027435612,-0.0073268753,-0.02684066,-0.022728804,-0.018795364,0.04884143,0.033844963,-0.086575404,-0.030103914,-0.1293888,0.014312166,0.020292962,-0.019629003,-0.014856928,0.03977289,0.023577321,0.031387925,-0.03724497,-0.06090946,-0.07908209,0.035994213,-0.04540468,0.04228597,-0.013029724,-0.0299772,-0.025772396,0.018015405,-0.037977748,-0.02615089,-0.025538255,0.05068452,-0.008950631,-0.07402318,-0.013023344,-0.022399051,0.04839901,-0.057716724,0.010632741,0.037482902,-0.090839654,-0.04490929,0.018107051,3.4372076e-33,0.030547805,-0.011515399,0.052988566,-0.017146055,0.02466223,-0.040308718,-0.06380237,0.0027197034,-0.056574285,0.029018862,-0.02410728,-0.03252127,-0.023685774,0.0024381767,0.011559397,-0.050443012,-0.020983081,0.026527938,-0.0016985898,-0.011446748,-0.020716863,0.08831263,-0.03294682,-0.07802214,0.11667358,0.014456158,-0.03013811,0.021091375,0.024197942,-0.0145773925,0.01612628,0.05212061,-0.012899342,0.067027435,0.036553968,0.039630998,-0.08569695,-0.00063979055,0.0044756955,0.03145468,0.11336496,0.017407868,0.022393603,-0.014561343,0.059171572,-0.052176036,-0.018791435,0.06511888,0.01664966,0.028405141,0.083200485,-0.03130403,0.09407062,-0.042390756,0.023080872,-0.013526377,-0.08389335,-0.01825772,-0.0011556107,0.08605998,0.021436702,0.022791548,-0.080878414,0.009998927,-0.022036249,0.0228681,-0.121854484,-0.005714229,-0.009643831,-0.03807901,-0.010230476,0.0044148886,0.054044012,0.061185285,-0.0068667782,0.022089776,-0.08887013,0.029980587,0.069765605,0.019599551,-0.011974073,-0.07641649,-0.034449693,-0.051181685,-0.103090584,0.035757296,-0.03615112,-0.029864023,0.010623841,0.036183592,-0.005246836,-0.05960646,0.04790691,0.04630963,0.035108067,-5.817383e-33,0.13344608,-0.10815049,0.09383161,-0.013662347,-0.03299605,0.015663918,0.04643687,-0.06687889,-0.034406196,0.025937833,0.01811711,0.01958674,-0.00059534435,0.038572095,0.015464992,0.061924435,0.055088487,0.057291843,-0.026380138,0.01197836,0.038685698,0.07699819,-0.03563274,0.06944549,0.050218347,0.04782784,0.01594522,0.0062709055,0.07090345,0.060079183,-0.0772023,-0.008041135,0.03846395,-0.045494758,-0.00811579,0.04708254,-0.033883113,0.019728202,-0.029769963,0.01834401,-0.0080264695,0.031640492,-0.032245077,0.060790345,0.008438941,0.035147615,-0.07832298,0.004514354,0.023290465,-0.01988278,0.016008845,0.000486665,-0.043530203,-0.034917086,0.027980236,0.15212338,0.027432285,-0.07097111,0.047171716,-0.052830745,-0.10676433,-0.030032627,-0.028603073,-0.11385525,0.04198969,0.058176875,-0.05638161,0.08808509,-0.004493438,-0.0583223,0.08820496,0.08231877,0.07895191,-0.005123455,-0.08247626,-0.08812481,0.0009975204,-0.09137709,0.037948452,0.07069278,0.02355443,-0.042240858,-0.013244523,-0.004266256,-0.00049570145,-0.059272476,0.03460063,-0.023161003,0.012007243,0.071223125,0.01578349,0.02382428,0.02261326,0.034172177,0.040712986,-2.9089692e-08,0.062143844,-0.058736913,0.037228946,-0.081702,-0.06497889,0.048007447,0.005868717,-0.0417029,-0.0025439877,-0.07194444,-0.009434195,0.075847745,0.024819406,0.06231684,0.028905736,-0.013931584,-0.07269147,-0.028563486,-0.034494292,-0.014370756,-0.15680355,-0.014811959,-0.013574394,0.009344657,-0.014414859,-0.105841406,0.08741205,0.065836065,-0.0051094503,-0.007919683,-0.025052423,0.038968828,-0.019749254,-0.0011957076,0.06565969,0.05961807,-0.048619863,-0.04736261,-0.064330705,0.083280995,0.03839361,-0.04155015,-0.067472145,-0.029021123,0.059660673,-0.067967,-0.076075345,0.04640172,-0.03867877,0.050060876,0.041429404,-0.032325607,-0.03927254,0.0014698649,0.001426736,-0.05124797,0.010503827,-0.027001897,-0.047483508,-0.019475501,0.013471731,0.062244315,0.19605201,-0.038723744 +6.2.1.24,Not identical with EC 6.2.1.20 long-chain-fatty-acid---[acyl-carrier-protein] ligase.,384,0.99999994,-0.042171177,-0.06915141,-0.013863993,0.024210673,-0.0131676225,-0.013774701,-0.097527474,0.07067904,0.025836697,-0.09255537,0.13918866,-0.0355665,-0.035487223,0.024510741,-0.0016355432,-0.053841274,-0.039610274,-0.07866271,-0.06987806,-0.044098318,-0.0090253735,0.013040037,-0.024220606,0.0049005826,0.0033217296,-0.10608441,0.069650754,-0.0035683594,0.0044253855,-0.101833455,0.0006198297,-0.061801814,-0.030957906,0.0052958746,0.03503131,-0.014741135,0.032080296,-0.060556676,0.028576909,-0.016521236,0.056191444,-0.08781799,0.012786073,0.012960097,0.009903448,0.003702514,-0.044164196,0.06422083,-0.024901697,0.037219737,0.009225027,-0.09939063,-0.008639681,0.005588503,0.041177638,0.103248104,-0.11677707,-0.01808014,-0.03265304,0.062821984,0.0018365949,0.0355398,-0.025747757,0.049690325,-0.07313599,-0.064926565,0.13753404,-0.07148181,0.041181374,-0.012986885,-0.012880962,-0.14739653,0.009384625,0.07569994,0.041390616,0.09220237,-0.055955317,-0.07619334,0.053434446,0.004469965,-0.0312288,-0.045665745,0.026443765,-0.00078764936,0.020392891,-0.05331335,0.0226411,-0.037636727,-0.11193618,0.048436247,0.04085164,-0.06785029,0.0502886,-0.026241217,-0.07645937,0.03610322,0.0059594973,0.078580916,-0.01896998,-0.030473506,-0.012073642,0.110414684,-0.050637476,-0.0143272355,0.0029893536,-0.004591929,-0.028689638,0.10813646,0.0019091903,-0.03494566,-0.0100751985,-0.034277964,0.026667088,-0.027868446,-0.016540103,0.061016858,-0.04646271,0.002617953,0.0835066,0.051691003,-0.0075110947,-0.023066249,-0.022392238,0.04396684,-0.050532814,-0.03837711,-0.06291005,-6.180523e-33,-0.012924576,-1.2657596e-05,0.025693307,-0.01963933,-0.009637015,-0.0024634835,-0.08261836,0.073878065,-0.07740371,-0.041138176,-0.007957135,-0.0283451,0.032398436,0.04052823,0.052344684,-0.07635613,0.0036662547,0.07385492,0.014836531,0.03492088,-0.00077647885,0.100775324,0.05947275,-0.064772695,0.10009692,-0.015073005,-0.038865805,-0.005169806,0.011186373,0.03297469,-0.10852837,-0.057571705,0.0075553684,0.02849194,-0.049392454,-0.0046330723,0.04034436,-0.0764835,-0.07431896,0.031441644,0.08340032,0.030038735,-0.040968925,-0.04428545,-0.039018735,-0.038936555,-0.04275583,0.0052248337,0.012027593,0.02495097,0.013167556,-0.034274742,0.07692831,0.023827665,0.015276548,-0.023125425,-0.09114728,0.020877281,-0.0047042565,0.010354473,0.04448683,0.11666373,-0.05175962,0.055155765,-0.023407353,0.038740583,-0.06432821,-0.018420855,-0.062238153,0.051245816,-0.02155585,0.040626578,0.078193806,-0.012424894,0.05166177,-0.06135098,-0.11735275,0.05190115,-0.03381981,0.05214786,-0.0234264,0.02267962,0.08850439,0.006573232,-0.02759501,-0.032388564,0.008370485,0.050627574,0.039492004,0.03895782,0.06911416,0.02986804,-7.98519e-05,0.08645169,0.017292483,3.19706e-33,0.030744057,-0.07021578,0.042081643,-0.06810731,-0.006101743,0.072649136,0.08253989,0.053716306,0.009081117,-0.055134106,0.15256928,0.0031955037,-0.04675586,-0.10400666,0.05876717,-0.023447474,-0.06950377,-0.00094097084,0.07033488,0.056565724,-0.014199198,-0.05341121,-0.015146974,0.075469024,0.07900617,0.037842788,0.015141154,0.03999809,-0.015121697,0.028726155,-0.001200936,0.0065354845,0.03095911,-0.024789138,-0.07368501,0.055490427,-0.08690433,0.016455939,0.056782838,-0.037369456,0.012315981,0.027265748,-0.016312506,0.034382284,0.043661397,0.014139437,0.0751974,-0.03826972,0.059832457,-0.07095813,0.031285834,-0.023641253,0.007950169,0.011296886,-0.028256217,0.031072227,0.008456648,0.054843865,0.025818603,-0.036481712,-0.04018279,-0.0076834154,0.0026842407,-0.0092890095,0.04532223,0.025052072,-0.009708802,-0.018633017,-0.017839288,-0.014559871,0.04860621,0.02315766,-0.07207164,0.041207477,0.013028534,-0.07993249,-0.053670835,-0.014791184,-0.041015524,0.023650564,-0.015186745,-0.007510469,-0.03617689,0.014290565,0.06114201,0.021437544,0.03937578,0.033312246,-0.02124844,0.092859015,-0.028297802,0.02675971,-0.09823663,0.017390992,0.04854321,-2.7191794e-08,0.1532455,-0.08109303,-0.012637379,-0.043092974,0.012839222,0.01784926,-0.04986736,-0.026305074,0.0022717554,0.0076450096,-0.036940236,0.06035256,-0.011949744,0.01973906,-0.023509817,-0.06751599,-0.082962684,0.043604147,0.038065184,0.013250287,-0.078293525,0.023668913,-0.018776149,-0.02383298,-0.04116431,-0.011709573,0.030897262,0.06211016,0.0003710516,-0.06848989,0.022194054,-0.009822957,-0.02245974,0.030523213,0.0023408914,0.009515209,0.026786786,-0.030589323,-0.07834919,0.12809391,0.03301529,-0.03951574,-0.029082755,0.017405534,0.11402973,-0.007979964,0.05377401,0.00082379836,-0.022512868,-0.012090482,0.013770826,0.0126010105,-0.05079986,-0.08028844,-0.034260653,-0.05736004,-0.046799757,-0.08348585,0.0044404464,0.018312182,0.06717854,-0.020929044,0.17505194,0.0030215415 +6.2.1.25,"Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.",384,1.0,0.040713746,-0.10173026,-0.06426554,-0.03583692,0.08539662,0.006632468,0.058000144,0.0056450167,0.040070236,-0.017821368,0.030964676,-0.058137387,-0.050203655,0.09996098,-0.02791156,0.07854917,-0.027085626,0.019348618,-0.035391208,0.046527974,0.003017784,-0.06603724,0.043495387,0.00042879788,-0.019581951,0.061030924,-0.013228702,0.008455857,0.043512516,-0.1315149,-0.011465833,0.10473753,0.030211907,-0.021744957,0.052518718,0.016204001,-0.04131113,-0.01986472,0.0030762984,0.046877377,0.02154729,0.01858049,0.052405454,-0.04004952,-0.0032964803,-0.005586518,0.03499656,0.006322907,0.0370075,-0.004850207,-0.043880027,-0.002888551,-0.05556397,0.06609924,-0.06753859,0.033731937,-0.07273008,0.0606643,-0.022972079,0.011007514,-0.03207648,-0.05863635,-0.012400159,0.020715937,0.035222962,0.059112456,-0.007827105,-0.050405897,0.012982115,-0.01094584,-0.025514554,0.0078760395,0.03320855,-0.019379737,0.046718877,0.021000534,0.034974452,-0.023888225,-0.01248473,-0.05559237,-0.07549062,-0.04400193,0.124340735,0.02226111,0.028317003,0.0048882733,-0.01789653,-0.039771188,0.013764347,0.06924479,0.037622847,0.093097515,0.03117522,-0.019183809,-0.09587852,0.07168315,0.04151607,0.043703064,0.02297314,0.0058678635,0.05910406,-0.05086873,-0.037717223,-0.010077602,-0.0073243333,0.019340247,-0.013045348,0.042402554,-0.07558834,-0.028784629,-0.06411266,0.051084593,0.094773985,-0.0076562962,-0.02523167,0.010913552,0.05668445,0.013777765,-0.0062828087,0.053490337,0.022082977,-0.022078859,-0.009624316,-0.03319211,-0.037799213,0.124826245,-0.038031604,9.374134e-34,0.06609517,0.02802919,0.028747166,0.012022907,-0.061583478,-0.002058195,-0.06838839,-0.04483662,-0.091703154,-0.040452972,0.027664015,-0.0077399374,0.026002714,-0.05209775,-0.0033410108,-0.06289962,0.04097413,-0.02150563,0.0068525155,-0.04447465,0.061825667,0.10736549,-0.09982306,-0.02765815,-0.014468902,0.0032544984,0.0048748483,0.020997932,-0.026877718,-0.0024170128,-0.004076473,0.057973284,-0.09678473,0.013050225,0.05709825,0.05536571,-0.052377246,-0.045068514,0.013974986,-0.026833698,0.0012148492,-0.00028996,-0.067082524,0.015649457,0.073854506,-0.06800752,-0.07400812,0.105934046,0.09507089,0.081184074,0.023965318,-0.04813703,0.05283065,0.028207038,-0.004899369,0.037396237,0.009991137,-0.042686515,0.019912772,0.0007474399,-0.00801067,0.017994655,-0.11816274,-0.019367818,-0.011360016,-0.037086353,-0.009220882,-0.012558887,-0.0035449332,0.0008048964,-0.02201605,-0.041801613,0.07951233,0.05908367,0.1068624,-0.08265766,-0.025840793,-0.09890108,0.045754973,0.033476543,0.054385982,-0.043612447,0.05164866,-0.025491478,-0.1649511,-0.017055245,0.0062624654,-0.060625114,-0.018129764,0.0018758695,0.093514554,-0.09592192,0.0143602835,-0.056544796,-0.0031921982,-9.434333e-34,0.025783496,-0.060404953,0.04686154,0.051458582,0.0056615826,-0.024010748,-0.0342752,-0.035460237,0.017918658,-0.003371204,0.12083929,-0.039978463,-0.062452003,-0.049133178,-0.07142893,0.07301926,0.12356003,-0.0023147638,0.039649107,-0.035026234,-0.05520812,0.046238545,0.010105889,0.10461264,-0.049269903,0.06328381,0.037402593,-0.021502428,0.06310141,0.03478197,-0.07997753,0.050792247,-0.03963817,-0.04297857,-0.04175847,-0.010882559,-0.06002794,-0.021230401,-0.048240103,-0.0048874454,-0.055194724,-0.038775142,0.051231395,0.03185109,0.02302704,0.09378746,-0.014367327,-0.018370038,-0.064362116,-0.0074514095,-0.058558296,0.023853403,-0.075234644,0.04716767,0.043156452,0.01468387,0.002510485,-0.12031543,0.023352914,0.04630193,0.037034523,0.0182621,-0.011159742,-0.062300544,0.07853227,0.034800597,-0.060742404,0.07184217,0.100468636,0.005438284,0.06410519,0.016941266,0.075192146,-0.013678855,-0.07736609,-0.043849375,0.0017532504,-0.059023466,-0.05481143,-0.07518541,0.021836389,0.021905115,0.0337649,-0.06416034,-0.11127441,-0.09122926,-0.01788962,-0.01640523,-0.036575187,0.05866511,0.0062170085,0.035450436,0.10372659,0.06360413,0.06901159,-2.560082e-08,0.023478769,-0.012464606,0.053470835,-0.056627207,-0.015828036,0.07064463,0.04086013,0.03875032,0.057003595,-0.051473934,-0.053572413,0.06701325,0.12390275,0.011107763,0.07125854,0.025888063,-0.0045700823,-0.051309776,-0.056370072,-0.033979468,-0.08802327,0.020964097,-0.052008003,-0.022484176,-0.05381088,0.005592743,0.016925883,0.046595603,0.0474141,0.019024337,-0.028790865,-0.0016297095,0.053176954,-0.018965548,-0.042422973,0.049720593,-0.017387602,-0.088743314,-0.088314414,0.028355084,0.03305575,-0.0018901295,-0.059691478,0.051186368,0.01915102,-0.0522902,-0.0161379,-0.06704427,0.03448083,-0.08122688,0.083183974,-0.0004980762,-0.046505917,0.00037417107,-0.07346387,0.04050834,0.040340576,-0.027645633,0.045318764,-0.07318176,-0.056519333,-0.059902914,0.07486408,0.011444728 +6.2.1.29,Not identical with EC 6.2.1.3 (long-chain-fatty-acid---CoA ligase) or EC 6.2.1.7 (cholate---CoA ligase).,384,1.0,-0.03114371,-0.092594564,0.012693686,0.021842286,0.005905408,-0.040973693,-0.11389509,0.066508494,0.011645872,-0.1021981,0.1196754,-0.04933697,-0.060482897,-0.01078109,-0.009528151,-0.083660625,-0.022595292,-0.039602395,-0.004931514,0.025952967,-0.01488503,0.030888507,0.013250176,0.053203065,0.033547312,-0.018518185,0.0831564,0.015795702,0.04583543,-0.108809,-0.015397234,-0.030384721,0.011094893,-0.052988283,-0.012754957,-0.024078734,0.067374274,-0.048658557,-0.026975995,0.015797071,0.05079578,-0.064864464,0.058944564,-0.014922703,-0.013063626,-0.029213691,-0.04527294,0.021144675,-0.04087547,0.03968345,-7.657271e-05,-0.107687265,-0.047158513,0.023428798,0.0515738,0.06664227,-0.14763215,-0.044216003,0.015028159,0.06985582,-0.05356153,0.046702906,0.0030635344,0.05137342,0.0061412444,-0.04678401,0.12770835,-0.11520682,-0.0071027637,-0.03634443,-0.05262355,-0.08583531,-0.0016959729,0.08235478,-0.000956801,0.12336801,-0.05716935,-0.052926134,0.009532972,-0.035064626,-0.051490724,-0.024356278,-0.0494539,0.01693996,-0.021396607,-0.0052056285,0.029560018,-0.031476513,-0.080917105,-0.013090434,0.06873316,-0.034351885,0.05984767,-0.012944657,-0.09200722,0.038706955,0.008481768,0.15948834,0.057124164,-0.03206466,0.008671273,0.10433445,-0.111487485,-0.028470695,0.04762239,-0.02518608,-0.03749891,0.09883904,0.028543256,-0.020292973,-0.020035896,-0.05797042,0.010400014,-0.02682085,-0.03887978,0.02098004,-0.012683766,0.0218611,0.09525535,0.13657424,0.04419952,-0.032466587,0.012279397,0.014841969,-0.03158084,-0.0381926,-0.02067442,-3.8940958e-33,-0.016237017,-0.01483913,0.10166942,0.006680069,-0.018159,-0.01133798,-0.089002185,0.046949625,-0.09033104,-0.022899687,-0.028090449,0.04467789,-0.01363314,0.039871663,0.033032797,-0.05056219,-0.009682011,0.04266395,-0.0025401444,0.038157515,0.025095351,0.08018016,0.017310679,0.00899574,0.07460752,-0.031035518,-0.015380279,0.051442597,0.01298685,0.025060022,-0.055450164,-0.06137113,0.041938175,-0.019063419,-0.06681166,-0.010662783,-0.01349862,-0.060482506,-0.07314438,0.070509665,0.097439356,0.02717062,-0.0219092,-0.014960661,0.0045649507,-0.05228159,-0.0015046934,0.018840156,0.044755656,-0.026507024,0.010878568,-0.025070688,0.07392135,0.003439239,0.060884926,-0.033472992,-0.042236865,0.05306014,-0.0007289698,0.070047386,0.03874863,0.1455751,-0.05906253,0.058726825,-0.034167577,0.040808357,-0.060762808,-0.039689973,-0.050031126,-0.025291923,-0.025634684,0.025488162,0.033184882,0.0480308,0.04667619,-0.071361914,-0.09551447,0.042140678,-0.016717961,-0.034439776,-0.055967867,0.053543128,0.04304932,0.005794835,-0.06425441,0.020951696,-0.028115956,0.024713594,0.021849599,0.05067789,0.04772946,0.004224464,-0.016028311,0.03453863,0.002565087,2.2227068e-33,-0.018829213,-0.030640228,0.018647157,-0.027987229,0.0037341467,0.07626275,0.11076607,0.033465773,0.052342378,-0.06181291,0.16679665,-0.035654947,-0.04304328,-0.07618834,0.089349695,0.014498364,-0.022280063,-0.0011510288,0.02483867,0.03582066,-0.010785238,-0.021448793,-0.037989784,0.037212,0.07129677,0.041514482,0.028250659,0.015176963,0.011758583,0.03567116,-0.035065934,-0.019296478,-0.00025725996,-0.0040799333,-0.09518827,0.0130463755,-0.049169857,0.010214019,0.019749206,-0.067525044,-0.07449601,0.03403408,0.035514724,0.013772879,0.020632684,0.011253152,0.09524262,-0.03711472,0.028976807,0.015359636,-0.0439249,-0.016545521,-0.05583236,0.029786842,-0.0013792774,-0.0026125875,-0.0026120918,0.03264594,0.018985918,-0.04477226,-0.010682807,0.02182813,0.017940106,-0.043635733,0.075305015,0.07980807,-0.022871725,-0.024014378,-0.010295669,-0.028058179,0.06342704,-0.009295437,-0.03618232,-0.032174766,-0.0014215722,-0.059878934,-0.0097006215,0.015933033,-0.04161841,0.00461869,-0.01703704,-0.012771065,-0.05691904,0.043607216,0.009693593,0.01752107,0.051722284,0.027053738,-0.00059468666,0.09653169,-0.048793186,0.017832194,-0.10261132,0.005709613,0.06205723,-2.7215268e-08,0.1311957,-0.1143808,-0.053502865,-0.027461488,0.049287885,0.008368795,-0.08815549,-0.02111424,-0.020328185,0.04132779,-0.030060874,0.08582646,0.043944713,-0.024989597,-0.022550285,-0.050325885,-0.003023144,0.046378486,0.010724195,0.0047328817,-0.058397993,0.014991822,0.0056222733,-0.01795365,-0.04162592,-0.009625114,-0.0009567666,0.057877608,-0.0047334093,-0.06654836,0.05029359,-0.000493376,-0.00876655,-0.014589982,0.002213756,-0.015164405,0.0027901758,0.014730771,-0.0617679,0.13739824,0.06481379,-0.100720845,-0.034670133,0.015586549,0.08211874,-0.004294423,0.017104497,0.012962799,-0.01095816,-0.025297964,-0.017682513,0.00058662955,-0.051984224,-0.058905378,-0.004770226,-0.045191005,-0.0013586615,-0.09484727,-0.004613795,0.026738292,0.060727723,-0.036086585,0.1885711,0.023152485 +6.2.1.30,"Also acts, more slowly, on acetate, propanoate and butanoate, but not on hydroxy derivatives of phenylacetate and related compounds.",384,1.0,-0.017091347,-0.1612713,0.020027878,0.004002942,0.067834586,0.048543602,-0.08131631,-0.045919977,0.022978043,0.025944486,0.09860813,0.017273229,-0.06446732,0.057523422,0.01047576,0.075734824,-0.016326481,0.048503853,-0.018869532,0.06698321,0.047464997,-0.046948012,-0.006256535,0.04538145,0.032715067,0.008057337,0.021379286,0.051357526,0.0690476,-0.06429268,-0.0031718886,0.03427441,-0.0553851,-0.005594544,-0.022057952,0.036005143,-0.029251222,-0.032963473,-0.013671178,0.00919623,-0.0033871345,-0.055807516,-0.031246802,-0.061337125,0.03575826,-0.033976432,0.024649356,0.0043206513,-0.039574135,-0.053635146,-0.047411934,-0.013211068,-0.069624394,-0.003134443,-0.05986052,0.02314976,-0.06628849,0.04935386,0.05356544,0.04857743,-0.036722064,0.0021131448,-0.05200328,0.03437572,-0.024656923,-0.0024210045,0.037268203,-0.032827802,0.05484105,-0.0061389958,0.0035238916,-0.034782805,0.06941525,0.02753052,0.05416786,-0.04195335,0.0049776495,-0.016362099,-0.002167482,-0.10415744,-0.033397943,-0.02977538,-0.020968547,-0.03458548,0.03418181,-0.010319744,-0.0450613,-0.05987541,-0.024465758,-0.015627354,0.031015968,0.028551549,-0.031610858,-0.024902178,0.00038051937,0.016520787,0.105260864,0.028966075,0.027503394,0.011129589,-0.05294259,0.053361557,-0.097542845,-0.068162,-0.0047318223,-0.024062783,0.0256965,0.022794934,-0.018520584,0.06406019,-0.053222965,0.016024295,0.04275042,-0.0059423805,-0.0745677,-0.0029691719,-0.013728889,-0.07806514,-0.012695984,-0.030253412,-0.022849068,-0.031850077,0.053012505,0.09687913,-0.050244447,0.048739295,0.021932501,1.1519205e-33,0.03507748,-0.06105508,-0.032276895,-0.03098874,-0.00017240159,-0.0103661595,-0.059756696,-0.012630384,0.0060260617,-0.12858622,0.00408651,0.015105274,-0.018150114,0.016337462,0.009346764,-0.05166642,0.004393485,0.0041663577,0.060156878,-0.022700302,-0.02815408,0.027794275,-0.06563935,0.06905031,-0.01785083,-0.11431232,0.0040463656,0.0644279,-0.033701293,-0.025882125,0.012389917,-0.09809158,-0.0061665,0.009582171,0.030648034,0.10125991,-0.07367636,-0.07630132,0.0011838374,-0.032882314,-0.02132901,0.016953034,-0.04169628,-0.026616242,-0.030143743,0.0072369813,0.035140164,0.064825684,-0.019895647,0.006329751,0.040348038,0.019786905,0.054388802,-0.017287696,0.008905397,0.027784636,-0.006003798,-0.01444779,0.004822027,0.040568665,-0.04014833,0.03278457,0.030211091,0.01917551,-0.027939385,0.056464642,-0.069135785,0.054681044,0.04215979,-0.026208866,-0.012839737,0.023027947,0.12594904,0.010056946,0.12341854,-0.062155027,-0.02645025,-0.036827523,0.023290643,0.031831354,0.01125181,-0.034014378,-0.02877822,0.07046423,-0.077522255,0.02762625,0.01588021,-0.020632299,0.051802456,0.071596526,0.0138325095,-0.10444227,0.017221147,0.018569754,0.06513603,-3.5331735e-33,0.009172453,-0.09240548,0.0020465164,0.08465523,-0.0024713767,0.05170888,0.05340344,0.0014637257,-0.012432697,-0.10202117,0.10940008,-0.034917314,-0.04284118,-0.055348832,-0.042530064,0.08257705,0.045111075,0.064289026,0.025897719,0.053327885,-0.0007493977,0.06527239,-0.009395218,0.1051046,0.023156347,0.011370579,-0.041493762,0.01722669,0.008924535,0.08094098,-0.012267203,0.02136966,-0.094589666,-0.05790901,-0.008144564,0.09045561,-0.05216374,-0.00026938767,-0.10234396,-0.011652391,0.04393257,-0.033316374,0.04523928,0.043571293,0.069770865,0.062748685,-0.009445991,-0.008208112,-0.05136093,-0.009396007,-0.0020303226,0.059089955,-0.058812756,0.0063749542,0.025154479,0.055517208,-0.008365159,-0.054989878,-0.049730867,-0.05770054,-0.017827148,-0.08736232,-0.009741091,-0.07986303,0.0062435176,-0.004864513,-0.077783234,0.047023233,0.14382759,-0.052329846,0.04247387,-0.044727948,0.07847333,0.06334614,-0.051195655,-0.082455054,0.065376036,-0.108132705,-0.12378634,-0.05788381,0.02965573,0.0148964645,0.009061834,-0.057124086,-0.13071516,0.09399765,-0.055175032,-0.048876073,-0.02587384,0.05898504,0.00010596494,0.019380603,0.0060774684,-0.006431758,0.022380609,-3.2162582e-08,0.03601999,-0.04445,0.18969265,-0.046681356,-0.01703781,0.044058118,0.11333661,0.023731362,-0.01261779,-0.07408496,-0.0085474765,0.08016376,0.035472635,-0.0012769947,0.02470976,-0.009570855,-0.042080957,0.016919576,-0.048002828,-0.026967704,-0.12123024,0.016162226,-0.06487432,0.05236114,-0.019284857,-0.014948075,0.031041412,0.051467463,0.029180884,-0.058980748,0.08776641,-0.00036486794,-0.008578447,0.0079660425,0.040481992,0.04940844,0.10009938,0.012907546,-0.059601035,0.06005341,-0.06544292,-0.027394075,-0.06281068,0.07662617,0.045275655,-0.0012792663,-0.01641307,-0.005685086,0.03615194,-0.003109092,0.09378196,-0.014015839,-0.038912278,-0.093681544,-0.02321917,0.0016624391,-0.012813924,-0.031088253,0.016288767,-0.049179845,0.021226428,-0.0203938,0.17753594,0.0063476134 +6.2.1.33,"Requires Mg2+. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.",384,1.0,-0.04262293,-0.045204815,0.012939879,-0.0103021525,0.09666172,-0.09417792,-0.0057716155,0.03841358,-0.05868075,-0.011339531,-0.04117772,-0.03921387,0.010267117,0.07801951,-0.014449999,0.07729065,0.004457006,0.03948409,-0.026468858,0.02830842,0.10276088,0.023852106,-0.036658682,-0.022006389,-0.0011448616,0.068351805,0.11198972,-0.02140151,0.021200288,-0.04040376,0.02932537,0.036644734,0.11144007,-0.0965357,0.058074243,0.12002196,-0.022030681,-0.049920436,0.03506864,-0.012767873,0.0037164395,0.064355634,0.05960955,-0.004377604,-0.0075956457,-0.046318732,0.04126991,-0.010014012,0.06424005,0.021262724,-0.061724883,0.04186907,-0.06887836,0.008015324,0.04132969,-0.0042440393,-0.06724067,0.030624235,-0.07317931,0.0006772764,0.0022928321,0.0018221252,-0.03394436,-0.015534015,0.018768022,0.002291843,0.05668807,-0.056062527,0.043654848,-0.027539572,-0.058827363,-0.038573585,-0.022753043,-0.0022237098,-0.028857103,0.029130705,0.08135457,-0.060044862,0.037172917,-0.022256576,0.00182884,-0.017258674,0.11230149,0.030694883,0.042995885,-0.018123105,0.025567703,-0.057372026,0.030283388,0.09291848,0.056578323,0.07088809,0.017333632,-0.01624246,-0.015710331,0.060479775,-0.09372669,0.0045647174,0.01095569,0.004557341,-0.042879142,0.022315051,-0.01977148,0.008884738,-0.079652496,-0.024144614,0.026187446,0.055116426,0.01866682,0.03528915,0.0956384,0.04560237,0.08403305,0.05584452,0.04748509,0.062337738,0.014198648,-0.07764866,-0.030620364,0.044197716,0.014325711,-0.02771164,0.016012864,0.015039805,-0.09856426,0.046627402,-0.0630777,6.0861964e-34,-0.002243532,0.005536009,0.039370213,0.012056957,-0.057388246,0.038927384,-0.084519245,-0.032891776,-0.036535475,-0.09957588,0.0030129617,-0.10766192,-0.03254592,-0.0016087492,-0.01610994,-0.07004019,0.03023153,0.041422322,0.076220386,0.033898555,-0.033244666,0.059807125,-0.034086596,-0.030542145,0.047804967,0.13280252,0.06580464,-0.060756158,0.08652529,0.0073537533,0.039944436,-0.08857897,-0.076681525,0.02329917,0.01620063,0.013200611,-0.037903152,-0.033463374,0.0058805947,0.00955979,-0.06611877,0.017597884,-0.07826428,0.006291691,0.06937124,-0.096470855,0.0017887221,0.08348791,0.01907151,0.08588292,0.02892968,-0.019685421,0.03402044,-0.0006573253,-0.06420599,0.035618145,-0.019798158,-0.010185365,0.09105967,-0.026422,0.014204336,0.09278487,-0.046934247,0.05509898,0.08388139,-0.051167388,-0.043335173,-0.0493414,-0.0037177692,0.06711204,-0.0322363,-0.098852284,0.056807484,0.050085418,-0.0050268723,-0.075238176,-0.021788359,0.031034818,0.09691261,0.00075990375,-0.0067172144,0.00066061376,0.003336681,-0.046104837,-0.0997359,0.03017911,-0.009813267,-0.034862813,-0.00629027,0.032210276,0.064642884,-0.06061801,-0.074247405,0.06601578,-0.010849689,-1.0519074e-33,0.064896226,-0.03415965,0.049477547,0.016022751,-0.08701149,0.026025958,0.009544076,-0.08659618,0.045086246,-0.006734521,0.043441564,-0.018035289,-0.04727281,-0.07649952,-0.0042317407,0.010673893,0.016324362,0.04279295,-0.078849636,-0.05071851,0.050570168,0.1190143,0.010730021,0.019352753,0.006017191,0.027202621,0.012765585,0.051281046,0.07754416,0.061078973,-0.03890708,0.12295587,-0.016786443,-0.05154995,-0.07822274,0.004126118,-0.045968145,-0.03940997,-0.06293764,0.032040652,-0.040639795,0.05532951,0.028567811,0.028446866,-0.015314979,0.066992745,0.018509937,0.031447582,0.08446552,-0.06160488,0.002060179,-0.037525963,-0.08474865,-0.017339634,-0.024422107,-0.034600902,0.013402006,0.0069619613,-0.0019488296,-0.026519915,-0.018282466,-0.03688413,0.08554268,-0.045476686,0.033634514,0.08004838,0.039004453,0.09108842,0.023781285,0.011590479,0.047580317,0.033558313,0.10346599,0.0041533387,-0.028640816,0.06913142,-0.09755355,-0.013207169,0.021021312,-0.07472837,-0.011990955,0.037272364,-0.038694944,-0.021207515,-0.028120764,-0.16788636,-0.020676414,0.06611142,-0.030720036,0.028830696,-0.06621767,-0.0793927,-0.044338096,0.050157484,0.019808108,-2.6482546e-08,-0.06969532,-0.06307331,0.04499325,-0.06014082,-0.004476838,0.08949069,-0.005781909,0.011272654,0.09723133,-0.038280733,-0.02977252,-0.005481297,-0.034751587,0.030113379,0.02087,0.029802851,-0.039796423,-0.068135865,-0.038295474,-0.042950943,-0.06316534,-0.07228359,-0.10499498,0.035120036,0.011250354,-0.06272258,-0.008174524,0.066180214,-0.022145355,-0.01593315,0.005599344,0.041612353,-0.0021260811,-0.043511987,-0.0994439,0.015863357,-0.019591639,-0.038682178,-0.025586756,-0.017705794,-0.025984153,0.02627691,0.011335633,-0.0060464265,-0.006178252,-0.011602463,-0.024075685,0.012274756,-0.05563895,-0.024510251,0.055409074,-0.052360453,-0.04797816,0.002068947,-0.0638565,0.01681098,0.06576376,-0.053306058,-0.024893288,-0.08777775,0.0053363317,-0.02268758,0.11700198,-0.07507188 +6.2.1.34,Requires Mg2+. It has not yet been established whether AMP + diphosphate or ADP + phosphate are formed in this reaction.,384,0.99999994,-0.11358419,-0.04987101,0.013657419,0.025234537,0.020857692,-0.07554804,0.019218827,-0.014615371,-0.08295793,0.062041,0.041220948,-0.036455557,0.012082081,0.027009144,0.009528663,0.022833802,0.035984986,0.011213903,0.07041265,0.03379114,0.092452,-0.01737913,0.015904227,-0.066923365,0.06001379,0.053756554,0.028122433,0.010366969,0.05189948,-0.017979704,-0.034569155,0.013349641,0.03507021,-0.13726066,0.022207243,0.12906356,-0.06611486,-0.032408714,-0.03501787,-0.027276287,0.0473669,-0.03135561,0.059548587,-0.04701588,0.029160554,-0.08865189,0.070458986,-0.044859525,-0.0018540111,0.002918395,-0.039882705,0.0006956602,-0.000280783,-0.033755507,-0.026704041,-0.062552474,-0.11091608,0.04277715,-0.017266834,-0.044743963,-0.054555275,-0.0060433866,-0.08180187,-0.050273817,0.09869377,0.016378477,0.042439595,-0.06695741,0.05921339,0.032831583,-0.0304611,0.0035668032,-0.001852371,-0.03294292,-0.03697713,0.041894574,0.045542333,-0.04477045,0.10474552,-0.032366324,0.016822549,-0.017778508,-0.031491093,0.022670899,0.017042719,0.048040323,0.0070914906,0.040392604,-0.04574154,0.012009179,0.03178476,0.065862484,0.005341338,0.0171863,0.0046011438,0.039079014,-0.082943015,0.06532857,-0.012429723,0.006921445,-0.036048766,0.10285674,-0.069774136,0.0025526364,-0.005728824,-0.042732045,-0.024224145,0.049136937,0.00037914203,0.067842774,0.060536943,-0.007821005,0.0625688,0.009702249,0.029428756,0.07763301,-0.051520076,-0.10880577,-0.04007211,-0.034641482,0.057599492,-0.049622867,-0.07766286,0.04246528,-0.024574777,0.017830506,-0.020764798,1.6300791e-33,0.051047135,0.047538064,0.07787646,-0.020056007,-0.052954044,0.06331291,-0.0882039,-0.05292355,0.0018701388,-0.03492889,-0.037144266,-0.108917676,0.05798706,0.026372438,-0.0790228,-0.055101648,0.0120377345,-0.0069522425,0.15894508,-0.0060519,-0.015334071,0.048925053,-0.06183381,0.044757448,-0.03642635,0.08109619,0.004723673,-0.030907609,0.03559149,0.006227024,0.07425867,-0.09314629,-0.10592902,0.026398445,-0.00090355676,-0.043763924,-0.040605273,-0.059868976,0.02762437,-0.012756459,-0.023796896,0.012414237,-0.024272092,0.07229875,0.06352604,-0.10166026,0.0013400565,0.029088289,0.03425937,0.11696638,0.04652975,0.0027885837,0.02301682,0.017885465,-0.07069958,0.039866216,-0.047196783,0.020908026,0.04790485,0.08092287,0.013703815,0.038993977,0.011804724,0.019654764,-0.013019589,0.052148413,-0.04549262,-0.06528913,0.02922778,0.003128182,0.0445532,-0.038120206,0.042699948,0.061117027,-0.0055400254,-0.0059433836,0.023878962,0.05818701,0.04357389,0.026256634,-0.009800843,-0.039102156,0.0038630816,0.028683549,-0.057729155,0.00070915837,-0.0054478217,0.0027618078,0.0084580565,0.048917875,0.0037982583,-0.0052139885,-0.06382403,0.042322148,0.00804659,-3.3633586e-33,0.05310992,0.015373289,-0.029115792,-0.08212653,-0.11872875,0.013422328,0.09064909,-0.12949803,0.039377175,0.007829273,0.074756965,-0.016279565,0.0040135146,-0.034194987,-0.040901635,0.017839039,-0.06632736,0.048449762,0.0077852933,0.023371616,0.015940359,0.13668041,0.059819672,0.11454118,0.064713724,-0.008416296,0.03394233,-0.040257227,-0.0023978224,0.077104986,0.026901957,0.076152325,-0.08663876,-0.028485602,-0.04343702,-0.019261984,0.00588574,-0.008500129,-0.024254575,0.05531907,-0.0054456517,0.032547418,0.07052699,0.059579585,0.041432884,-0.01613175,0.08741625,0.0257186,-0.02358897,-0.06242314,-0.0029644594,0.010770242,-0.06379306,-0.081270166,0.033135794,0.0508215,-0.004941174,0.020210467,0.0076718642,-0.045900714,0.036594566,-0.026593342,0.0334642,-0.15184042,0.03361305,0.10124522,0.050722945,0.030379374,0.043309387,0.0043465667,0.062289182,0.05292636,0.059702583,-0.050788313,-0.0062904414,0.0705813,-0.07012745,0.0048248894,0.04978024,-0.12136741,0.012830409,0.0794601,-0.0016481301,-0.03793289,-0.013852414,-0.08102024,-0.024818614,0.03474589,0.0050462037,0.012943702,-0.08907357,-0.046384018,-0.01833717,0.04576712,-0.00621812,-2.7632174e-08,-0.0077497996,0.019439787,0.03526816,-0.04423971,-0.00038311997,0.06347547,0.0023223157,-0.09164763,0.0281769,-0.029145913,-0.0036299871,-0.007595464,-0.029141594,0.0052021146,0.035509452,-0.059273653,-0.008408339,0.040511295,-0.102874205,-0.111756794,-0.027460547,-0.052331362,-0.08631032,0.07561076,0.027913375,-0.030910315,0.024133606,-0.017391667,0.010235671,-0.040757105,0.03483421,-0.010780945,-0.07210438,-0.08281571,0.015162714,0.054626618,-0.006534913,0.009312216,-0.033148058,-0.08948178,-0.14753322,-0.03589732,0.060209986,0.01516174,-0.04180342,0.050512057,-0.032578036,-0.0028565293,-0.030841323,0.0050442973,0.034202084,-0.091892764,-0.019399485,-0.08051709,-0.0325267,-0.004082521,-0.010119073,-0.023244305,0.0028208513,-0.043525036,0.044258766,0.03605514,0.012972627,-0.059156623 +6.3.1.2,"Glutamine synthetase, which catalyses the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. Several types have been described, differing in their oligomeric structures and cofactor requirements.",384,1.0,-0.06276217,-0.030598134,-0.064653225,-0.07093478,-0.0051495233,-0.027085902,0.019798283,-0.0077092713,0.009507405,-0.004712392,-0.007866621,-0.046401627,-0.028848311,0.025174666,-0.078642264,-0.011420155,-0.056454305,-0.072547026,-0.03126979,-0.075320825,0.06559785,0.12403439,-0.042204604,-0.049751658,0.046271052,0.05070049,0.020319525,-0.07922715,0.081476554,-0.03852788,-0.03989616,-0.009217316,0.030611975,-0.014203982,0.03722575,0.058061205,-0.055009697,-0.021965692,0.0443649,-0.002135575,-0.0015745956,0.04828322,0.027525803,-0.07424363,-0.040357,0.0021871184,0.07568001,-0.020735178,-0.0067593087,-0.015586901,-0.002531325,-0.07348812,-0.04252627,0.02210698,0.10209904,0.020487592,-0.1348065,-0.03439056,-0.02624999,0.04484477,0.012731175,0.049672104,0.019328615,-0.12718876,0.12100299,-0.0052890773,0.04621552,-0.05997392,0.039712895,-0.09991072,-0.03123637,-0.042657927,0.028878475,0.005685624,-0.053490125,-0.010422937,0.013713095,0.039963964,0.060418762,0.010443174,0.06512089,0.008664929,0.03326923,0.052558657,0.05564484,0.0040812255,-0.0452648,0.08294692,0.07945975,-0.042685058,-0.04274628,-0.034050517,0.03444624,-0.057179563,-0.0031027254,0.054301716,-0.014152527,-0.015389425,0.054157782,-0.012528868,0.006575035,0.02542467,0.0063460143,-0.016852457,-0.054067813,0.035436343,0.04447204,0.14609124,0.01685062,0.029912138,-0.0208932,0.04370051,0.04646551,-0.012747742,-0.055010427,0.02178001,0.002270044,-0.034189437,-0.093962826,0.014709748,-0.0035676651,0.012669559,0.012094559,0.07221197,-0.03075842,0.06646527,-0.0752488,2.7977724e-33,0.044563416,0.033901095,0.014898417,-0.024220143,-0.009548605,-0.014855701,-0.055038337,-0.014746559,0.08914419,-0.10439386,-0.08996549,-0.035325658,0.0054914844,0.008776315,0.0040622475,0.016086433,-0.03817972,-0.008954758,0.051266633,0.0031757697,0.014187062,0.033591073,-0.015295605,-0.0053096926,-0.03090744,0.059852578,0.02929605,-0.014947833,0.04963828,-0.046403952,-0.018469479,-0.12257598,-0.06530426,0.0017901993,0.023898683,-0.0378672,-0.06107619,-0.01500657,-0.011355286,0.074657455,-0.03029233,0.032941055,-0.030582031,-0.032221172,0.06872427,0.034376428,-0.043036077,0.05714389,0.0022917867,0.042558126,0.01740655,-0.030502884,0.057244126,-0.053992014,-0.06372246,0.052043438,0.028827127,-0.025382856,0.06375113,0.0551766,-0.043092605,0.019017594,-0.022228368,0.023695307,-0.0059047234,0.03610323,-0.034639537,-0.049649213,0.09051309,0.10236026,-0.02104176,-0.033795934,0.03792307,0.12994805,-0.02595808,-0.08838347,-0.03452726,0.0054569826,0.01313583,-0.017634433,0.07898016,0.06329317,-0.00081411813,0.005975255,-0.038435683,-0.052919276,-0.021731447,-0.07837493,-0.023771077,0.027055267,0.0065145767,-0.045587666,-0.025619313,-0.007148016,-0.028204778,-2.8516027e-33,0.110598855,-0.041744307,-0.028916394,-0.07908247,-0.03661816,0.009912162,0.0037548228,-0.08359645,0.01775935,0.026829466,0.006221032,0.029791217,0.08275703,0.03411728,0.043060184,-0.04938234,-0.026532445,0.057783015,0.027522964,-0.03683236,0.002731981,0.056557722,-0.044798337,0.016631644,0.0647114,0.022405833,-0.015358654,0.064078055,0.02440886,0.03366111,-0.04233989,-0.037615918,0.018545616,-0.09448218,0.026730018,0.021868471,0.055884205,0.0015927441,-0.069685765,-0.053187713,0.00888121,0.10155333,0.09108833,0.06520296,-0.05766003,0.050458442,-0.075470656,-0.02388526,-0.02935669,-0.03600665,0.06865459,-0.021895016,-0.048269805,-0.111989625,0.029459191,0.06815079,0.041030657,0.026416706,0.026241954,-0.0070503633,-0.001084458,-0.13957381,0.03387146,-0.027322298,-0.0022274603,0.02398452,0.042240027,0.007822479,0.0015781793,0.02009929,0.023391435,-0.04755717,0.10549601,0.06789825,-0.025650239,-0.05222135,0.013588542,-0.038448185,0.029928252,-0.08834088,0.012741193,-0.053725358,0.016237836,-0.027484972,-0.0042751296,-0.041530773,0.05905575,0.15207624,0.048439477,0.056151517,-0.013534249,-0.047141507,-0.081179276,0.063049875,0.03453869,-3.3467884e-08,0.043597266,-0.059195112,-0.005973892,-0.0019379304,-0.030206027,0.11777782,0.019613283,-0.040941343,0.08382129,-0.027450068,0.03870589,0.051978827,-0.05664359,0.050209515,-0.07323501,0.01870441,-0.0660047,-0.017368728,-0.059860144,0.0025135123,-0.073924005,0.048190262,-0.10000734,0.0013454898,0.041981332,-0.088449925,-0.008890621,0.09630939,-0.018160367,-0.030222047,-0.016719833,0.06528312,0.068070486,-0.09433064,-0.12148672,-0.04171647,0.08705261,0.04737034,-0.013811819,-0.041837815,0.001510333,0.037511796,-0.02861413,-0.00846747,0.03292238,-0.002757676,-0.018704018,0.0041327523,-0.016135793,0.062194277,0.04705883,-0.04484548,0.04935325,-0.03796193,-0.06518259,-0.054607473,-0.059333935,-0.015551491,0.014783057,-0.053427707,0.048978318,0.025745256,0.1807746,-0.008513798 +6.3.1.5,"L-Glutamine also acts, more slowly, as amido-donor [cf. EC 6.3.5.1].",384,1.0,-0.010186426,-0.15054551,-0.027914215,-0.029909624,0.10715129,0.0058668694,-0.018335192,0.08430302,0.05454628,0.008974291,0.05122628,0.026193528,-0.004480159,0.0667195,0.008637808,0.047917187,0.008096788,-0.058603294,-0.110675715,0.034918748,0.039067265,0.03201136,-0.036510237,-0.048754826,0.035398494,-0.010372119,0.011312025,-0.055647377,0.03974097,-0.056645416,-0.09033131,0.05545843,0.015422509,-0.027389735,0.015870737,0.06361203,-0.06162974,0.0048401025,0.03351769,0.019262506,0.011671367,-0.04431213,0.028718764,-0.031588946,-0.012643645,-0.021573404,0.03476378,0.060799874,0.03702641,-0.0023996958,-0.0008622967,-0.06513612,-0.072299026,0.03170853,-0.0378576,0.046590995,-0.155959,0.027219519,-0.020128343,0.01614177,-0.1560021,0.036805186,0.01911013,-0.030562757,0.08797221,-0.01388163,0.12877639,-0.09860761,0.029054908,0.012993441,0.020357411,0.004123232,0.045114335,-0.03706942,0.048439316,-0.08083547,-0.0072011137,0.084793895,0.04590407,-0.043212805,0.055140637,-0.0069101886,0.004196745,0.03630653,-0.058974557,-0.030417236,-0.043565802,0.00861209,-0.00830854,-0.07474687,0.05364448,-0.0017620258,-0.08120067,-0.004946992,-0.03778181,-0.044603143,-0.0014364045,0.022098146,-0.028330516,-0.022459446,-0.038669657,0.07416527,-0.109499626,-0.022465583,0.022324558,0.009968016,0.051506307,0.040100433,-0.053046644,0.0363487,0.052922785,0.012942503,0.02975623,0.05429744,-0.09879812,0.053487163,0.051489692,-0.04842005,-0.082130864,-0.04990445,0.02529729,-0.020296268,0.022971626,-0.0008031756,-0.048247088,0.07427359,0.013409098,-3.5105676e-33,0.011965639,-0.034684684,0.019670356,-0.060731404,-0.03413659,-0.006001709,-0.09963105,0.0009524113,0.029856527,-0.08322844,-0.10306754,-0.043964904,0.02100822,0.040683344,-0.0703852,-0.03225237,-0.0081422385,-0.0006044167,-0.013486057,-0.057554007,0.017867105,0.0867253,0.010039944,0.024873141,-0.019277375,0.065138035,0.027522808,0.03786013,0.029583165,-0.022032756,-0.036517397,-0.027590256,-0.0071140607,0.025828488,0.00614728,0.07117609,-0.020893475,-0.05008135,0.056857426,0.029860487,-0.049019877,0.07526253,-0.07698912,-0.030927815,0.023278886,-0.032054868,-0.059455846,-0.018402154,-0.05790613,0.066034205,0.07332938,-0.07702761,-0.007452561,-0.003913684,-0.08676397,-0.01984295,0.0023484312,0.0065380307,-0.023543064,0.0786202,0.008585179,0.0025043709,0.030247483,0.029696302,-0.014823124,0.071550764,-0.07202647,0.0032346912,0.015343556,0.07027778,0.009696975,0.0058778357,0.040920977,0.07270461,0.04415516,-0.06541546,0.034011096,0.054925274,0.044223342,-0.04773114,0.08447302,-0.005604897,0.053968683,0.1000971,-0.058316328,-0.054892734,0.018392384,-0.07551567,0.003985105,-0.017059604,-0.046177033,0.00030697632,-0.008199132,-0.028438974,0.023843776,1.6292556e-33,0.13098906,-0.077628694,0.037926532,0.055680342,0.04682742,0.05439246,0.022632062,-0.022308223,0.06990022,0.028621841,0.06476225,0.009100181,-0.017633116,-0.0149104055,0.018935401,-0.013969298,0.0076625487,-0.0031453036,-0.051219102,-0.007415895,0.016337194,0.023350311,0.05982913,-0.00096005143,0.05691931,-0.0393199,-0.029396662,0.023726908,0.02288006,0.0029481603,-0.027864205,0.010200772,-0.0814794,-0.14257158,0.0019595341,0.084854946,0.0072055166,0.0124876145,-0.07534184,-0.04494585,0.010246942,0.01174807,0.111129366,0.022765806,0.019533316,0.008019703,-0.0056581874,-0.06911399,-0.12772378,-0.010382654,0.04582925,-0.0006346378,-0.0028211796,0.016166443,0.055962615,0.08180108,0.017074998,-0.071093045,-0.0187198,0.0019354314,-0.035543572,-0.063226946,-0.050879993,-0.02548967,0.07561952,-0.0020713538,0.08279833,0.011299227,0.040959235,0.012021835,0.121565185,-0.050754067,0.04259883,0.10241359,-0.07360334,-0.061100263,0.016410857,-0.07500525,0.057689063,-0.08269165,-0.010984766,-0.007282605,0.03244041,-0.017076986,-0.06273972,-0.010064044,0.011523463,0.08181774,-0.0028447928,0.06894396,-0.003188122,-0.050322525,0.024708712,0.03786643,0.06459725,-3.0044436e-08,0.06532576,-0.03320099,-0.038232014,0.008689414,0.020694336,0.051686823,-0.020311516,0.060183145,-0.0039765798,-0.03279778,0.022120757,0.08840746,0.0014384253,-0.04736655,-0.03437607,0.036976986,-0.08434222,-0.023106422,-0.04812555,0.033166256,-0.1059101,-0.006458794,-0.061221667,-0.06959492,0.030857177,-0.060324382,0.017358517,0.104158066,-0.056136623,-0.08522667,-0.004841685,0.04357846,0.0018427671,-0.068329476,-0.058895137,0.024966564,0.08839518,0.02831005,0.038157433,0.047726203,-0.030315138,0.044435576,-0.021669865,0.0031551006,0.0134615395,-0.025299989,0.05593495,-0.01779421,0.023033101,0.0391907,0.03385462,-0.04051648,0.0113368025,-0.05892283,-0.07627055,-0.0071380767,-0.0788162,-0.017885728,0.15321673,-0.064731024,-0.011500095,0.009719656,0.11271711,0.057279423 +6.3.1.7,"Glutamine can act instead of NH3, but more slowly.",384,1.0,0.0045089102,-0.14148214,-0.020045005,-0.06903594,0.014178376,-0.02812005,-0.008868385,0.0016048461,0.017711136,-0.016757013,-0.013263934,0.020923527,-0.030622113,0.098086014,0.009517404,0.00536844,0.03752169,-0.04154448,-0.05612035,-0.01772063,0.03265418,0.07415773,0.0070466977,-0.0208615,-0.024634954,0.08274853,0.024667194,-0.022577878,0.041370176,-0.040796716,-0.04591989,-0.040364314,0.014483399,-0.016566554,0.019226309,0.02963026,-0.099492736,0.046317372,-0.006536898,0.010562139,0.042506114,-0.0029249925,-0.001565661,-0.05424026,0.045591425,0.035970137,0.03882877,-0.020764474,0.022018656,0.057007197,-0.004434035,-0.074053764,-0.00086227007,0.003422593,0.030716594,0.0007141534,-0.21660872,0.0100702075,-0.053262003,0.06339158,-0.076489836,0.017058464,0.013880797,-0.09839897,0.14673354,0.0108187245,0.07576065,-0.08738578,0.044114627,0.02200264,-0.025522593,0.008071387,0.027696481,0.03202538,-0.040635083,-0.033243492,0.013617497,0.00027539846,0.06276181,-0.0051349755,0.02073092,0.02918189,0.084366366,0.09282059,0.0021957352,-0.0010209321,-0.07779642,-0.014218829,-0.007908399,-0.020536697,-0.02662169,-0.010899789,0.07332289,0.078241885,0.0073227794,0.008578986,-0.0144813955,-0.008201466,-0.007541678,0.003771079,-0.026135733,0.06189714,-0.11091678,-0.029855149,-0.03276897,0.046528596,0.047716275,0.058483608,-0.054203276,0.09796683,-0.019981582,0.060348738,0.034410994,0.005318817,-0.10908375,0.03097095,0.030958297,-0.02414548,-0.061619233,0.018597716,0.0027270997,-0.014526355,0.0036504273,0.03385942,-0.033916462,0.0612114,0.020700548,-1.0125367e-34,0.009114114,-0.04275027,0.04603958,-0.004496932,-0.03189772,0.04259004,-0.07964784,-0.0038671042,0.071029335,-0.08945712,-0.09924205,-0.048130803,0.026069893,0.0050116507,-0.043089487,0.023672197,-0.04758255,-0.009633669,0.00870653,0.010702001,0.05408896,0.038854867,-0.0218199,-0.013806767,-0.10515946,0.048056506,0.01600179,0.043312896,0.05792893,-0.035423838,0.008965451,-0.109651156,-0.07541676,0.013520883,-0.024495421,0.07956239,-0.07614289,-0.04348867,-0.0026616445,0.033306193,-0.0880798,0.0751476,-0.075552136,-0.043414183,0.014793372,0.027426746,-0.035110146,0.054284472,-0.102691375,0.061203755,0.08257007,0.0010798996,-0.005758549,0.02577619,-0.011872589,-0.007259765,0.045443192,0.010353175,0.037324432,0.07119419,-0.023342516,0.0051173647,0.012640419,0.02962978,-0.009179654,0.084609926,-0.08929461,-0.011314956,-0.0077611995,0.059760418,0.014217863,-0.013425934,0.0022431726,0.06114303,-0.023158828,-0.11174946,0.0039085736,0.03482533,0.025684875,-0.011286189,0.06434004,-0.047858816,0.03836654,0.058731295,-0.08864508,-0.051112942,0.0060741585,-0.11237726,-0.031951558,-0.028332725,0.023680829,-0.047742408,-0.0067455275,0.0019653535,-0.019755874,-5.44163e-34,0.06492481,-0.06779015,-0.0010561686,0.06602526,0.00932411,0.02617037,-0.008391735,-0.025084186,0.00707027,0.040872563,0.09401255,-0.016176952,0.007399408,0.076953605,0.01580369,0.014787801,0.016209615,-0.01002527,0.020035004,0.033653073,0.018026898,0.049842957,-0.06511544,0.08439909,0.011313667,0.020653982,-0.0042520664,0.0032646635,0.0031531255,0.036028326,-0.05180496,-0.022516232,-0.053951215,-0.088861145,0.056369834,0.017032377,0.019278964,-0.049897276,-0.1259264,-0.10289651,-0.0077708275,0.033429638,0.053224165,0.07188983,-0.0063034017,0.12993999,0.0014653832,-0.02524822,-0.05058792,0.06649572,0.02091228,-0.033572413,-0.012543945,-0.039502528,0.08598606,0.011661029,0.04149499,-0.07616353,-0.027131958,0.028673528,-0.010590212,-0.0815459,-0.03675816,-0.05889423,0.057505783,0.04086274,-0.007822661,0.039172553,0.07606224,0.027945379,0.009190372,-0.062079456,0.09670964,0.017681839,-0.0437467,-0.061112896,0.035549033,-0.035341755,0.002754887,-0.1112525,0.005958582,0.0051085055,0.044260412,-0.047678433,0.018180631,0.05728435,0.05012239,0.07157783,-0.047873177,0.10872418,0.03040854,-0.0073280637,0.0054895263,0.044372026,0.020983228,-2.0114287e-08,0.08735723,-0.038167793,0.048828814,-0.005051253,-0.07170027,0.09303064,-0.013359116,0.059757795,0.00011315709,0.0066927117,0.046994895,0.098137535,0.021608923,0.010364716,-0.021766288,0.02974124,-0.060600307,-0.045445308,-0.038813192,0.012480209,-0.16517858,0.053507727,-0.07187455,-0.029132724,0.029576166,-0.065640904,-0.008531811,0.07159477,0.034589265,-0.08695627,-0.01861534,0.027826477,0.099940345,-0.06365491,-0.11434069,-0.0215226,0.04051584,0.053952973,-0.015879242,-0.010192334,-0.05040578,0.068291046,-0.017297253,-7.72343e-05,0.027105518,-0.06298604,-0.0139110945,-0.035726156,0.0065510077,-0.018013176,0.014275996,0.022151928,0.033048958,0.002224452,-0.028629633,0.008013046,-0.10274087,-0.08948859,0.05750766,-0.046697948,0.014539392,-0.08149738,0.040842608,0.07397478 +6.3.1.8,"Requires magnesium ions. Involved in the synthesis of trypanothione in trypanosomatids. The enzyme from Escherichia coli is bifunctional and also catalyses the glutathionylspermidine amidase (EC 3.5.1.78) reaction, resulting in a net hydrolysis of ATP.",384,0.99999994,-0.012139729,-0.043788433,0.0041215187,0.016784564,0.0054667606,-0.021507716,0.0080599,0.012638072,0.005641274,0.039928474,0.044436198,-0.10242464,-0.0066176504,0.117999725,-0.050686993,-0.09755618,0.0069781737,0.07295866,-0.030448388,-0.067205936,0.03711029,0.065646745,0.035972714,-0.028046146,-0.0485591,0.046204302,0.056029014,-0.040574774,-0.007996122,0.0026410657,-0.12775233,-0.017226515,0.019210609,-0.14757659,0.05133509,0.0988201,-0.05513103,0.04867017,0.0078566065,-0.054338243,0.006452545,-0.008835463,0.08600531,0.0007440999,-0.042024672,-0.09079033,0.097576745,0.0061695008,0.06618938,-0.03901935,-0.048026618,-0.0035643172,-0.044504195,-0.056627594,0.03158075,0.04631617,-0.0361795,-0.0053375727,0.0028976223,0.027856981,-0.02783825,-0.00038205116,-0.023431556,-0.056472685,0.10122712,-0.082880214,-0.01028202,-0.00033072082,-0.00064363994,0.0037609264,0.0047667655,-0.053299043,-0.03471153,0.027901849,-0.038266618,0.040617745,0.0342042,-0.04642017,0.07741246,0.01097228,0.0044800034,-0.09801626,0.04161029,0.047495063,0.058603577,-0.0012914732,0.0047016074,0.08321433,0.06268829,0.024076518,0.06929289,0.01697654,-0.013151457,-0.020963691,-0.011651612,0.05721051,-0.10108367,0.04384377,-0.031035354,-0.012193799,0.071261145,-0.021810565,0.019089565,0.006557446,0.029076265,0.025033198,0.022886287,0.09973743,0.059888333,0.04170195,-0.006919185,-0.021029321,0.047517635,0.028574366,-0.031982753,0.039061006,0.03428073,-0.06860762,-0.075619005,-0.04261945,0.014569597,-0.0005221614,0.01003834,0.014486717,-0.011283908,0.04620626,-0.040120255,4.1332714e-33,0.045438062,0.0003695008,0.053417258,0.030742811,-0.051206034,0.012195842,-0.05058705,-0.025759669,-0.031517413,-0.06982566,-0.06557057,-0.039491083,0.024714991,-0.00839969,-0.04951461,-0.041453216,-0.04440232,0.018601747,0.0795584,0.026781932,-0.02277475,0.047223166,0.0154103385,-0.045851495,0.022601403,0.053126615,-0.05613923,-0.040055253,0.026693491,-0.02593805,-0.025707686,-0.057406567,-0.104598835,0.06339847,0.0546532,-0.022747189,0.014532494,-0.04281786,-0.043934535,-0.010152045,-0.09684295,0.046603486,-0.055474345,0.014331918,0.046131812,-0.035922676,0.0068860636,0.07473871,0.0063758697,0.13194636,0.11069761,-0.039191917,0.08889678,0.04654832,-0.06837292,0.027013939,0.00055563264,0.028698172,0.08053175,0.07885314,-0.006513927,0.1020757,-0.045280118,0.025486352,0.021762857,0.041275438,-0.052622758,-0.08088327,-0.009440333,0.0471184,-0.03199148,-0.01599553,0.034724478,0.05003508,0.011633048,-0.028053263,-0.06853042,-0.013773188,-0.029229859,-0.025984012,0.06733307,-0.06931792,0.0057075573,0.0682055,-0.08562873,0.052554335,0.017417725,-0.04531076,0.01692239,-0.036419485,0.10761541,-0.05463017,-0.0024394568,0.079633854,0.029897213,-3.5222366e-33,0.07144742,-0.05126445,0.04080245,-0.0909364,-0.08207079,-0.028132731,-0.002428112,-0.13408515,0.020753412,-0.057389252,0.03932945,-0.077999584,0.018391177,-0.08782894,-0.05551962,-0.055970922,-0.0068461676,0.037928924,0.03638198,-0.05784689,0.014710615,0.06354346,0.0052056843,0.03447511,0.038797863,0.009686117,0.057493474,-0.015858378,0.010533764,0.019714108,0.010911253,-0.032299012,-0.047479104,-0.046701286,0.025810324,0.034560278,-0.0048520733,0.039203163,0.030806508,0.012703836,0.013304719,0.09686245,0.06573378,0.105876595,-0.028950203,0.113538265,-0.07058092,0.023780657,-0.03836284,-0.08309693,0.0103052575,-0.040501945,-0.049983297,-0.024770044,0.056976072,-0.013273805,0.06740303,0.006592279,-0.01598711,-0.02438213,-0.05990201,-0.055064183,0.02021603,-0.055515796,0.0604209,0.049863357,-0.07385254,0.0903461,0.0014303579,0.0651512,0.06496107,-0.037982803,0.08433643,0.044889532,0.008454948,0.04229388,0.0458625,-0.09637452,0.06831016,-0.037576318,0.044373088,0.04876907,0.0059817075,-0.015639313,0.00034045285,-0.11115683,0.01890827,0.0595952,0.023767028,0.028171042,-0.0064978143,-0.07129639,0.06273214,0.11135577,0.014323211,-3.4612235e-08,-0.013569713,-0.05099057,-0.015468494,-0.084087715,-0.012216276,0.073187366,0.020970566,0.007336037,0.11762976,0.006273423,-0.0066962135,-0.013196302,-0.0066275727,0.0027388255,-0.0041404837,0.054485295,-0.01724545,0.052383948,-0.026318274,-0.059503622,-0.09261095,-0.03696749,-0.1443525,0.001567787,0.003314046,-0.06816961,0.07159794,0.035146736,-0.032019217,-0.07120071,-0.09479377,-0.05543972,0.026893614,0.015260561,-0.040073514,0.04108025,-0.060012024,0.009488229,-0.032085385,-0.07152083,-0.045596126,0.027262175,-0.0077308896,-0.021679576,-0.003979587,0.0105586,-0.04495277,0.03902787,0.022590024,0.04322971,0.058232423,-0.016236512,0.024110975,-0.084941596,-0.070690356,-0.015059595,0.0018141281,-0.0033522735,-0.023117926,-0.028940488,0.027059373,0.05245373,0.11558574,-0.02186823 +6.3.1.9,"The enzyme, characterized from several trypanosomatids (e.g. Trypanosoma cruzi) catalyses two subsequent reactions, leading to production of trypanothione from glutathione and spermidine. Some trypanosomatids (e.g. Crithidia species and some Leishmania species) also contain an enzyme that only carries out the first reaction (cf. EC 6.3.1.8, glutathionylspermidine synthase). The enzyme is bifunctional, and also catalyses the hydrolysis of glutathionylspermidine and trypanothione (cf. EC 3.5.1.78, glutathionylspermidine amidase).",384,1.0,0.018890023,-0.03202524,-0.08575711,-0.030112106,0.047827993,0.023362732,-0.05035428,0.022012305,0.014346754,0.05740923,0.08074698,-0.070952475,-0.021961216,0.08590484,-0.092494056,-0.0055439975,-0.00027963004,0.011188232,0.005184658,-0.04770127,0.03381744,0.05412393,-0.0023402371,-0.008516139,-0.06227561,-0.0028937762,0.033881567,-0.05861523,-0.042116117,-0.019351799,-0.11313269,-0.031303167,0.0026580298,-0.09430483,0.0327138,0.048177715,-0.06866782,0.030696696,0.045369424,-0.024804601,-0.010189741,-0.039783448,-0.008840794,-0.058185995,-0.043903347,-0.054058656,0.057715975,0.053763766,0.094031334,-0.002510205,-0.04758228,-0.039753474,-0.05234737,-0.010717096,0.049390968,-0.012766638,0.011425887,-0.009354869,-0.007910461,0.09253037,-0.039535124,-0.0106873,-0.034432683,-0.11824507,0.09881045,-0.0909859,-0.027858928,0.007933785,-0.024115626,0.0010598479,-0.0051519424,-0.060686227,-0.006599679,0.0454756,-0.03131849,0.050928988,-0.023870708,-0.011658079,0.067019224,-0.010812811,-0.006103239,-0.102893405,0.052383818,0.026098678,0.031174049,-0.0055192593,-0.032873865,0.14045966,0.16379346,0.010122186,0.015996719,0.019961629,-0.02135067,-0.010973138,-0.027082432,0.049461275,-0.07271595,0.033173677,-0.013740848,-0.044557877,0.07002708,-0.09505903,0.0027138796,-0.070778295,-0.033160217,0.015513226,0.007740268,0.11635761,0.051267814,-0.0074267,-0.060215406,0.014409926,0.04684531,0.018980468,-0.049957246,0.050942045,0.04416521,-0.053994667,-0.07718462,-0.02739393,0.049194206,0.05116274,0.07877241,0.016347071,0.016480023,0.020761058,-0.010171673,4.360159e-33,0.06591435,0.050844893,0.020936836,0.069072224,-0.03587076,0.06428858,-0.04269814,-0.0031149779,-0.04096014,-0.084417515,-0.06015939,-0.015099457,-0.0011109785,-0.0019386034,-0.028691124,-0.0064697084,0.012927873,-0.026436113,0.03293538,0.034302365,-0.024325145,0.025944958,-0.040306944,-0.04241605,0.050052185,0.076822534,-0.061585438,-0.0011041019,-0.026072875,-0.038471367,-0.029955015,-0.029730644,-0.0885529,0.07837142,0.0589772,0.014813082,0.035864264,-0.060718205,-0.084543146,-0.03262045,-0.05501736,0.031307027,-0.03184701,-0.024109356,0.037500873,-0.047328603,-0.012644919,0.055530705,0.054322127,0.1187039,0.057734605,-0.030618424,0.1282874,0.03469765,-0.10994544,0.052758023,-0.01669347,-0.026427751,0.08956097,0.06401022,-0.02228951,0.07344629,-0.055619653,0.0008252476,-0.027862016,0.020265996,-0.06103033,-0.05205311,0.013177117,0.048360176,-0.0047029783,-0.027449805,0.008625501,0.026680982,0.050127756,-0.060181268,-0.04671988,0.010035904,-0.057582136,-0.020106088,0.045455117,-0.020316174,-0.01957336,0.033524882,-0.116431445,0.089800864,-0.0066213715,-0.03132306,0.028795678,-0.032715473,0.060813032,-0.06296612,-0.005930192,0.05969979,0.04777657,-4.439925e-33,0.09243446,-0.13135691,0.036631458,-0.074944384,-0.0007304505,0.015942678,0.022613453,-0.088697456,0.017350942,-0.05895428,0.016890392,-0.09019991,0.054322544,-0.038337756,-0.029826764,-0.022565093,0.005354322,0.014024109,0.054587066,-0.05903476,-0.025352204,0.07312183,0.011579183,0.035764284,0.03496054,-0.021574194,0.050839093,0.008725865,0.020346496,0.03009961,0.00015925111,-0.033068847,-0.03212388,-0.011608869,0.095384374,0.026544454,-0.034845512,0.036033574,0.054924075,0.034711014,-0.017352518,0.06496733,0.044405136,0.060671408,-0.023134096,0.11785723,-0.080913715,0.010097733,-0.04709383,-0.08495276,0.027499983,0.0058755595,-0.07316808,-0.01555324,0.06924988,-0.03258283,0.019334111,-0.022844652,-0.029035471,-0.027200062,-0.07347152,-0.06230942,-0.035816412,0.0032383162,0.079452924,0.051308207,-0.086873196,0.06657092,0.05362079,0.07525832,0.08612167,-0.074522726,0.10144726,0.055250328,-0.015850918,-0.035735507,-0.012548671,-0.06402274,0.066406585,-0.011143759,0.06604564,-0.017812774,0.063204326,0.0027085557,-0.045322444,-0.059516035,0.020802591,0.06343095,-0.01374788,0.053406503,-0.008733434,-0.044558793,0.048179362,0.12335041,0.041510273,-4.1621792e-08,0.037459586,-0.06254432,0.004293434,-0.07648413,-0.02224736,0.032490205,0.0072745956,0.0271174,0.089373864,0.012541255,-0.058179073,0.01282464,0.032507863,0.0063878167,-0.037216246,0.034553476,0.034311935,0.06365754,0.0054329317,-0.0056672725,-0.09897738,0.0059182034,-0.12131657,-0.033774387,-0.017790534,-0.024288723,0.052504208,0.006421111,0.015732884,-0.06575995,-0.10282841,-0.0041890205,0.011535203,-0.039830077,-0.048269138,0.058582157,-0.053282123,0.01991677,0.029599952,-0.039132237,0.039288674,0.009436563,-0.0013670424,-0.003266362,0.016705163,-0.012444989,0.025054395,-0.036052868,0.04738904,-0.0017633525,0.032827336,0.06452567,0.021932583,-0.05072124,-0.08273072,-0.03218391,-0.026319653,-0.03236717,-0.011570159,-0.049102865,0.023928981,0.06581982,0.14351565,0.012883391 +6.3.1.10,"One of the substrates for this reaction, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81, threonine-phosphate decarboxylase).",384,1.0,-0.048341382,-0.03418259,-0.06312778,-0.10210613,0.041525185,0.043340504,0.008727842,0.04760341,0.0058172657,0.09348893,0.0018009671,-0.051781684,-0.06298466,0.035953317,-0.061737657,-0.046092883,0.004433188,-0.026107436,0.04597629,-0.05689353,0.04787097,0.07487388,-0.008042686,-0.0017791351,0.06608256,0.033480294,0.08209064,-0.080795035,0.042253688,-0.036117766,0.04263351,-0.04910845,-0.0031950807,-0.0027349896,-0.012869835,0.07008109,-0.027475474,-0.07632309,0.06574218,0.0061522806,0.038981773,0.0062163165,0.01876533,-0.025334788,-0.026277002,-0.026241472,-0.011084858,0.024555385,0.02561141,-0.05485031,0.024352442,0.04003522,-0.05321123,-0.02652252,0.0013736049,0.017920077,0.014371261,-0.020518016,-0.07338677,0.012927938,0.040904425,-0.02246684,0.04041906,-0.031681325,0.060136355,-0.00067594566,-0.034508806,-0.02641821,0.040774625,-0.003750826,-0.053545307,-0.033709485,-0.020697074,-0.05829931,-0.0024261249,-0.015268524,-0.023904799,-0.08008081,0.060895145,-0.014519011,0.07670762,0.026648715,0.040985193,0.02597496,0.007972916,0.0053146286,0.007603505,0.023339815,0.06450108,0.00014377211,0.04116842,0.052600607,0.04897843,0.015813371,-0.10833258,0.01398244,-0.041282933,0.05413674,0.002067589,-0.018295713,0.010742438,0.031596433,-0.03876117,-0.07386298,-0.077093616,0.016023729,-0.017487727,0.07850529,0.025606599,0.03027157,-0.07444821,-0.0076954905,-0.0274953,0.06106749,-0.057765454,0.090106055,0.030815147,0.024017299,-0.00952163,-0.1068338,0.032575704,-0.011259207,0.048730947,0.057612963,-0.1144573,-0.011388993,-0.08523827,-9.047885e-34,0.08436836,0.037295237,0.011519334,-0.026379408,-0.019828781,0.013453605,-0.105217084,-0.01693476,-0.025127808,-0.10387095,-0.025522426,-0.07984785,0.0414946,-0.02802033,-0.0745595,-0.100385256,-0.0825724,0.06102826,0.050486363,0.03670921,-0.047030363,0.108632244,-0.054658953,0.11634804,0.017105188,-0.028678808,-0.04294843,0.064475015,0.0036460287,-0.013905519,0.0053512235,-0.015021389,-0.0558598,-0.048730366,-0.0034885053,-0.0664019,-0.073443554,-0.037967756,0.009939861,0.024533898,0.029526815,-0.018830685,0.007577402,0.002850645,0.023208901,-0.06826103,-0.01819815,0.11889273,-0.029881623,0.0532084,-0.007201954,0.00694657,0.034307897,-0.028023852,-0.008113871,-0.013688055,-0.039983507,0.0040520895,0.1491252,0.05179569,0.035482857,0.051934853,-0.025522891,0.048123617,-0.024727631,-0.0023253746,-0.041085195,-0.09266017,0.004646699,0.08903514,0.01634398,-0.0653459,0.06345556,0.017727017,0.061089925,-0.06504167,-0.0125447465,-0.003740207,-0.01330385,0.013246352,0.0058255466,0.055605784,-0.031976778,-0.101677805,-0.011434921,0.0023463375,-0.025793402,-0.06572837,0.00051757385,0.06088208,0.032202207,-0.065178186,-0.011216673,-0.003019918,-0.011092656,-4.565739e-34,0.05954826,-0.07219329,-0.020329917,-0.031661414,-0.09959499,-0.023273498,0.08340573,-0.10564108,0.067761,0.02253412,0.08180477,-0.05131599,0.016503043,0.024103642,0.029388562,0.021767013,0.047860008,0.033527717,0.01183559,-0.005891914,0.04152551,0.039882638,0.060782086,0.04436657,0.021046586,0.0032781127,0.04045888,0.032289278,0.018546514,0.06894871,-0.04513841,-0.00069983065,0.0024194391,0.008251555,-0.13959666,0.025199806,0.015473164,-0.06179824,-0.010602342,-0.025887718,-0.033850454,0.062198043,0.049187906,0.112269804,-0.013119884,-0.027290333,-0.044482287,0.023697687,-0.03886996,-0.06867185,-0.019509377,0.06028769,-0.022303954,-0.07099975,-0.02132109,0.065499,-0.017239356,0.036308527,0.024957689,-0.0048073693,0.0048254156,-0.042306095,0.018647367,-0.073907055,0.09623694,0.015911644,-0.024087995,0.08676381,0.07800395,-0.0171364,0.13001812,0.06082728,0.041016012,0.007182562,-0.007916659,-0.05203922,-0.082187,0.018658806,0.028186576,-0.008208637,-0.027379707,0.0011484547,0.0356724,-0.018075204,-0.047691494,-0.10528849,0.05688255,0.1176242,-0.03652453,0.11968617,-0.07171217,-0.014989295,-0.022889156,0.14766957,0.099942915,-3.4174402e-08,0.022107767,-0.06367717,0.049904294,-0.04961285,0.049894612,0.083709136,0.025315598,-0.05715675,0.044196934,-0.104769275,-0.070585094,0.050893206,-0.019651629,0.038982715,0.054829177,0.074264355,-0.104929954,0.06010919,-0.034528136,-0.053757746,0.008035721,0.011362371,-0.04360477,0.0334052,-0.07453914,0.014208363,0.06440393,0.0574823,-0.015590231,-0.067546576,-0.048866995,0.0037777596,0.016041271,-0.09218028,0.034329735,-0.0008751333,-0.043771073,0.009180781,0.007904439,0.020438347,-0.101996414,0.01847956,0.007731119,0.05263445,-0.010876393,0.048186332,-0.005349311,0.045413952,-0.081356734,-0.04045813,0.025901923,0.004610007,-0.02797024,-0.0134404255,-0.048231456,0.012101139,-0.08593493,-0.048311424,0.008247476,-0.00716077,-0.03527293,0.08095091,0.111246586,-0.03061107 +6.3.1.11,Forms part of a novel bacterial putrescine utilization pathway in Escherichia coli.,384,1.0,-0.032367423,-0.11973173,-0.078237355,-0.058839742,-0.049529962,0.0623945,-0.04588834,0.044229086,0.070794925,-0.027758133,0.043819733,0.025112107,0.044735942,0.10556556,0.021695469,0.012091228,-0.022327863,0.010265594,0.039115135,-0.02934123,0.066179164,0.08926005,-0.062978484,-0.031135593,-0.04526628,0.015336454,0.038464013,-0.02844489,-0.0015108591,0.015523438,-0.041057233,-0.03405218,-0.028305102,-0.13530561,0.04918911,0.044986088,-0.0013438467,-0.0043970305,0.09299097,-0.018666888,-0.027381407,-0.034175936,0.0122433705,0.03710962,-0.004293097,-0.0036602966,0.10287209,0.01995886,0.053144317,-0.048779182,-0.04600348,0.05475838,-0.00655587,-0.0030416846,0.09687799,0.034321073,-0.05922335,-0.013408093,-0.026865691,-0.021586083,0.027058225,-0.054075718,0.06316316,-0.002757738,-0.024366874,-0.026146956,0.013167985,0.018656433,-0.004440533,-0.05373012,-0.016770327,0.0013227621,0.07377137,0.061685663,-0.045297373,0.032523446,0.041818373,0.017176326,0.052062858,0.0045471718,0.0042178174,-0.037810583,-0.03153505,0.117880866,-0.06238921,-0.012841903,0.04450003,0.044048697,0.031767942,0.06635087,-0.0060819243,-0.04033416,-0.037291564,-0.12581189,-0.011580261,-0.022152625,-0.07074351,0.004610413,0.013771436,-0.059410278,-0.049668588,0.04972193,0.020971356,-0.004012471,-0.04268121,-0.07582315,0.0405531,0.15177281,-0.0010350395,0.059902024,0.044984434,0.036378462,-0.04114882,0.010520784,0.013447715,0.06111797,0.08980366,-0.09858781,-0.055863123,-0.012982221,0.008422274,-0.009138868,0.024515804,0.07891515,-0.08269127,-0.040536273,-0.03453622,-1.4553126e-33,-0.0014026914,0.001630993,0.049678594,-0.015612309,0.052269407,-0.008765493,-0.07964057,0.033651788,0.0193907,-0.06657823,-0.060982652,-0.09653165,0.031163933,0.02284937,-0.021623677,-0.042808097,-0.0052784206,0.04694356,0.040840574,-0.032786895,0.033028003,0.09774044,0.03870113,0.0018500972,0.061799288,-0.029298116,0.036383644,-0.030592006,-0.040655926,-0.027637767,0.025023934,-0.052557226,-0.09700375,-0.098483965,0.09453309,-0.052174482,-0.012909915,0.02812961,0.049599685,0.03740656,0.063224055,0.06683142,-0.04962835,0.01994353,0.05867582,-0.033059563,-0.045216545,0.09088191,-0.051158782,0.07995612,0.039947342,-0.048284944,0.05768919,-0.01586672,-0.097557515,-0.03559976,-0.034606885,-0.021176664,-0.0026258365,-0.004672126,0.024249723,-0.0076805633,-0.06077269,0.043051247,0.056791354,-0.040731397,-0.0650637,0.0043634116,0.011449615,0.09783665,-0.05885524,-0.0074025476,-0.0042371154,-0.02059916,-0.06424822,-0.09719525,-0.12786649,0.059616562,0.048859306,0.007421481,0.01963761,-0.027082184,-0.10088686,0.009746269,-0.006754419,0.043774605,-0.014876696,-0.039092496,-0.009064231,-0.010885327,0.12207118,-0.06712641,-0.03135635,0.047404792,-0.0066341027,-8.460217e-34,0.026605243,-0.097365,0.050485466,-0.06662294,0.0022406068,0.013221472,-0.02158927,0.008035684,0.06311195,-0.02355721,-0.033199295,0.049933873,-0.014502949,-0.026231457,-0.05465077,-0.028690793,-0.0024148903,0.015667377,-0.060251433,-0.026019558,-0.013274345,-0.064532876,-0.0016361543,-0.02248287,0.05152881,0.079836845,-0.02461199,0.12429139,-0.04455307,0.0659369,0.02636203,-0.03244474,-0.04147066,-0.034629688,-0.04303366,0.0439499,-6.582715e-06,0.08930898,-0.0015231213,-0.048411552,0.028444657,0.015861083,-0.086789824,0.09703564,-0.059517134,0.069677725,-0.013682424,0.019701831,-0.016228847,-0.062771045,0.03668888,-0.12032406,-0.011441946,0.0030515892,-0.013708701,0.024681797,-0.017074956,-0.001804307,-0.025741458,-0.054859433,0.007969872,-0.023952307,-0.026698524,0.008850863,0.029591272,-0.0649813,0.027103852,-0.009147914,0.006362072,-0.02550008,-0.052645706,-0.029579176,0.044292893,-0.0027730118,0.026298001,0.043115657,-0.10346071,-0.09938214,0.046561833,0.090936944,-0.121110715,-0.054803304,-0.06604629,0.0005943532,0.06973007,-0.012219944,0.04020591,0.102692775,-0.024215134,0.0009402301,-0.068057336,0.059368458,0.008060612,0.08091852,-0.0215931,-2.3382736e-08,0.04817425,-0.07948081,0.05781283,0.043412752,-0.0059995223,0.044659663,-0.03718838,0.04298907,0.06363149,0.022061108,-0.04571407,0.035521723,-0.021071475,-0.027751587,0.012193336,0.0751449,-0.010149129,-0.027061563,-0.042789783,-0.059968572,-0.076829135,-0.012498164,-0.05010301,0.032426734,0.050707817,-0.024879573,0.001693222,0.036524706,-0.00020332314,-0.07240758,0.04588975,-0.08605655,0.017750166,-0.01931816,-0.06182056,-0.0031218005,0.02304613,-0.0031869628,0.083834425,0.0011733238,0.0475672,0.014608319,-0.017880393,0.04633559,0.05486936,0.06697599,-0.086177,0.12077927,-0.057783805,-0.0900025,-0.014771824,0.01742684,-0.02074256,0.06535288,-0.062188644,0.03891419,-0.030066174,-0.051836606,0.055561315,0.04810196,-0.019544702,0.055089235,0.11469747,0.003286425 +6.3.2.2,Can use L-aminohexanoate in place of glutamate.,384,0.99999994,0.0135992635,-0.11005678,-0.011033386,-0.05679939,-0.051947925,0.061860874,0.022588102,0.09653228,-0.011534201,0.0017709966,0.049206685,0.046174992,0.012810942,0.065633744,0.014978845,0.043465316,0.06876026,0.007019115,0.0005867628,0.0039996295,0.09395889,0.06587237,-0.038845174,-0.100491695,0.08332836,0.04897858,0.031925872,-0.016748536,0.06449108,-0.027163276,0.025719037,0.032221958,0.008507441,-0.06408712,-0.08056842,0.039519724,-0.18763326,-0.060560063,0.08309493,-0.00784153,0.03253005,0.050450068,0.020348344,-0.14981283,-0.027869953,-0.03307709,0.021683782,-0.022353852,0.009808494,0.012785717,0.03323501,-0.06512821,0.013187052,-0.005191638,-0.03437619,-0.002166078,-0.11212735,-0.024843901,-0.017610984,0.0803896,-0.029163668,0.084807776,-0.008133931,-0.021930901,0.06021101,0.023649773,0.046892304,-0.015384935,0.08378591,-0.003570245,-0.026206475,-0.060559746,0.09788638,-0.022556772,-0.0048684357,-0.0010037656,0.0629658,-0.027185654,-0.009155638,-0.028845094,0.039092254,0.050441183,0.026405295,0.046383724,0.020057745,0.10858332,0.021602746,0.021744326,0.023117453,-0.025324762,0.030749267,0.024136677,-0.02593685,-0.03844192,-0.030386684,-0.05036029,-0.016235016,0.020837279,-0.041923292,-0.008248853,-0.0012734912,0.07688624,-0.040233023,-0.086512454,-0.08692023,0.020049792,0.028740207,-0.022941457,-0.037801873,-0.09491251,-0.021051396,0.05078455,0.0018082188,0.0016959795,-0.09856357,0.0074933316,0.08164292,-0.061991226,-0.08128621,0.044565603,0.020503825,-0.08015596,0.007400856,-0.0106467195,0.025679007,-0.00046902738,0.0035923133,1.4152638e-33,0.034586016,0.008451428,0.011215407,-0.040042046,0.089806564,0.045878146,-0.055951793,-0.039161526,0.08827007,-0.09175969,-0.06888515,-0.042776994,-0.0334796,-0.013330389,-0.022701928,0.014177125,-0.047990315,-0.019391268,0.053560264,-0.058138423,0.016848916,-0.016892776,-0.069803104,-0.005835319,-0.026231943,0.019095367,0.09175867,-0.029100861,0.043863527,7.459234e-05,-0.050048064,-0.026356544,-0.11642958,0.0065554744,-0.026342738,0.018733311,-0.07778787,-0.036774475,0.029844206,0.023194762,0.046260472,0.09321787,-0.03891527,0.09038085,0.0065595834,-0.021724615,-0.041150887,0.031177087,-0.013453618,0.041044604,0.08024561,-0.04613147,0.013879157,-0.07841105,-0.040817246,0.04944139,-0.0047244043,-0.05256148,0.08845466,0.044622116,-0.026123421,0.013093959,-0.059927642,-0.0041669426,-0.0015251648,0.0066364203,-0.017577354,-0.10342779,0.024829162,-0.076211065,-0.03591318,-0.097752415,0.102406286,0.051741462,-0.057276145,-0.08275615,-0.030380465,0.011487799,0.08184183,-0.042883355,0.10900609,-0.047948617,-0.0069670836,0.037891723,0.010188351,-0.026304146,0.015768135,-0.052828074,-0.009629336,0.0156209385,0.004891974,-0.034273192,0.010382249,-0.02524015,-0.03402711,-2.492627e-33,0.06757475,-0.084688485,0.0017118627,0.058729902,-0.005278297,0.039326545,0.060206506,-0.03936684,0.018304704,-0.009863048,0.03949495,0.03192263,0.02512614,-0.021751588,0.037430566,0.018395593,-0.02660622,0.037921164,-0.068758234,0.019966803,-0.028623916,0.020576762,0.039017342,0.021187648,0.13287789,0.03593205,-0.02039512,0.028086785,-0.011682098,0.050174583,-0.015947338,-0.06326301,-0.050982434,-0.16415787,-0.0051385984,-0.008124197,0.03709465,-0.03901322,-0.052751,-0.016005436,-0.025446787,0.079321474,0.08744844,0.03840094,-0.018530145,0.035478346,-0.050910108,-0.11070015,-0.028932981,-0.0024416442,0.062363658,-0.02194631,-0.08322771,-0.051627826,0.019477567,0.06481541,0.07015951,-0.060720697,-0.014935614,-0.016793456,-0.06558671,-0.07075613,0.018768333,-0.054727703,0.04273409,0.06031221,0.08373485,0.059742328,0.049249038,-0.018413644,0.06343181,0.004402156,0.09916427,0.055013496,-0.028061166,-0.02642829,-0.003954749,-0.019861147,0.026236773,-0.092923455,0.027661238,-0.014857812,-0.051272918,-0.036891207,0.020099506,-0.103711344,0.014141789,0.11316878,0.035756093,-0.016620941,-0.023534277,-0.028508343,0.018898526,0.032079026,0.12329896,-2.2890768e-08,-0.01357311,-0.042513143,0.022896463,0.028477697,-0.0023831497,-0.01148041,-0.0593517,-0.054687694,0.04471573,-0.08675211,0.029818727,0.07054782,-0.09474513,0.052523654,-0.036082175,-0.0014539852,0.012182153,0.06954669,-0.07295239,-0.0072501525,-0.09421594,0.033484016,-0.031829305,-0.016335221,0.09556006,-0.0031058989,0.0118887825,0.07176743,0.0012751187,-0.019120652,-0.030813828,0.043401565,0.034756113,-0.022083033,-0.06649407,-0.024786072,0.05347464,0.01891992,-0.03796608,-0.026053049,0.011262974,0.015442088,0.006032957,0.050180763,-0.0035473306,-0.0286652,0.055554476,-0.0026697011,-0.02563048,0.0011640165,0.040292718,-0.021244356,0.009791576,-0.023030128,-0.07864535,-0.0073809437,-0.040241107,-0.041663256,-0.0062553836,-0.09529712,-0.030801216,0.053960368,0.10686968,0.046354488 +6.3.2.4,"Involved with EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate---L-alanine ligase), EC 6.3.2.9 (UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase) and EC 6.3.2.10 (UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase) in the synthesis of a cell-wall peptide (click here for diagram).",384,0.99999994,-0.062026475,-0.118399434,-0.0461682,-0.10302898,0.028346354,0.06542767,-0.06676314,0.07207064,0.06709291,0.072615676,0.03213887,-0.04088296,-0.032770302,0.051228393,0.04170454,-0.0030374422,-0.047798503,-0.05513238,-0.03042006,-0.0064065866,0.054125488,0.054013215,-0.038294252,-0.041956607,0.073432274,-0.0020189309,0.09951272,0.001550363,0.03744749,-0.07772623,-0.0096760895,-0.10284752,-0.0026976028,-0.045795597,0.06113094,-0.0068396893,-0.039655462,-0.044057854,0.022275057,-0.02938132,0.038268883,0.018065719,-0.031011889,-0.0645633,0.10835596,-0.023846982,-0.02155664,0.04143587,-0.03560456,-0.014789301,0.044675324,-0.06680254,-0.010203196,-0.0062198658,0.0147666875,0.06546141,-0.16123231,-0.009576808,0.053211667,0.031962223,-0.028661726,0.044120185,0.005945773,-0.06390826,-0.066956975,-0.059750393,0.036722466,-0.067840986,0.05937088,0.018832712,-0.08516694,-0.09793547,0.0032776853,0.05288106,0.036955114,0.026856598,0.022734022,-0.022735463,0.0029416375,-0.081989646,0.031368997,-0.009938331,0.019172179,0.08891576,0.02744933,0.021279227,-0.0038228212,0.009410949,-0.00020287714,-0.029778518,0.08878716,-0.030794183,0.040576532,0.008976145,-0.038045608,0.0011880635,-0.027488299,0.047284912,0.063800156,0.04046942,-0.006204779,0.05876791,-0.059277426,-0.053758185,0.01839258,0.013611053,-0.004117378,0.15786678,0.023708586,-0.048263155,-0.03319649,-0.0125337215,0.035365064,-0.009675924,-0.05764655,0.056042287,-0.04349985,-0.08096302,0.067255415,0.020318795,0.109690845,-0.01373163,0.00995472,0.0952254,-0.07057247,0.030120758,-0.06776326,9.6115205e-34,0.058506798,0.025682602,0.021412013,-0.023637839,-0.018519392,-0.007126414,-0.026043374,0.010076961,0.00074479193,-0.036055382,-0.077456735,-0.083793506,0.03069115,0.09682407,0.014616341,-0.008780538,0.008855543,0.03480413,0.025812792,-0.0045248703,0.024205884,0.061405577,0.014698074,0.011323425,0.037743565,0.012677927,-0.0025051157,0.04954194,0.0505468,-0.0070840386,-0.10616535,-0.031594913,-0.041616883,0.025308777,0.0035817113,-0.026824584,-0.028532293,-0.098035716,0.040304508,0.05090937,-0.016332574,0.041249383,-0.05833094,7.207699e-05,0.077005155,0.002236896,-0.03208346,0.054338116,-0.030418437,0.016517337,0.07414598,0.0015470044,0.07806697,0.06012677,-0.027219275,-0.024566581,-0.09201572,-0.039542235,0.07099259,0.044415016,0.04124005,0.06926632,-0.021697944,0.006644571,-0.02571529,0.04724675,-0.040214166,-0.060650922,-0.022900185,-0.06521833,-0.017566044,-0.0021033688,0.08245135,0.018875383,0.030033315,-0.06260414,-0.05754227,0.063040964,0.019844692,-0.045106955,-0.034573976,0.10871706,-0.031736568,0.0007718953,0.00810944,-0.03979765,0.042834077,-0.10168598,-0.043221083,0.028677983,0.050014712,-0.029714003,-0.04504367,0.085929014,-0.026166214,-1.468494e-33,0.042296894,-0.03332636,-0.015299469,-0.045118567,-0.062438402,0.016933132,0.08871093,-0.0716671,0.10148999,-0.09333156,0.057488095,-0.017502548,0.025125932,-0.057561472,0.044117935,-0.030355364,-0.045911722,0.03642212,-0.012387345,0.03406943,0.028848136,-0.031092687,-0.030820115,0.059692983,0.09646555,0.0072522513,0.045633696,0.026486386,0.0463666,0.075168476,-0.018086331,0.0061244015,-0.040750638,-0.009835013,0.0039919047,0.093126655,0.023933852,-0.007763091,-0.004708738,-0.058151573,-0.004387435,0.055921376,0.028501576,0.028381104,0.04545362,0.08365027,0.047215026,0.016230475,-0.054015495,-0.04383186,0.01758728,-0.053723667,-0.0019469952,0.0023944513,-0.029915264,0.033925395,0.056091644,0.028430685,0.020149827,-0.016029978,-0.02790514,-0.0514965,0.024673987,-0.053431228,0.06408407,0.0681637,0.024618674,0.0630727,0.05098263,-0.013471344,0.0101761,-0.0064618643,0.027225051,0.04566609,0.034556966,-0.035939112,-0.043801505,-0.047345884,0.008078509,-0.00997883,-0.031793706,0.0061600436,-0.010012794,0.0017468234,0.032793954,-0.03272539,0.05755783,0.13525578,0.003833853,0.05286641,0.0035454652,-0.06895737,-0.015418699,0.097050086,0.061179418,-5.7424575e-08,0.15356524,-0.08235459,-0.036967732,-0.08024571,-0.0010624124,-0.009057902,-0.024916671,-0.045128834,0.022040438,-0.06157063,0.030174531,0.087050304,-0.05608143,-0.021235444,-0.028308827,0.03297023,-0.0588231,0.06780615,-0.021860216,-0.015635207,-0.05193023,0.048221182,-0.08892414,-0.01153962,0.0805047,-0.1384924,-0.030819744,0.026671248,-0.0033055109,-0.01913867,-0.0080652535,0.0064512705,-0.004637789,-0.04381,0.020320414,0.07378942,-0.009243124,-0.033760462,0.023214951,0.040138565,0.014818665,-0.06323127,-0.050561063,-0.013369481,0.077340536,-0.038412947,-0.029456466,0.011523484,-0.07668263,-0.062747076,-0.014070114,-0.033400223,0.009157084,-0.11387519,-0.09635578,-0.01420572,-0.12998006,-0.105553135,0.047053337,-0.03606448,-0.030664535,0.038272,0.11374971,0.014060574 +6.3.2.5,"A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC 6.3.2.51, which requires ATP. Cysteine can be replaced by some of its derivatives.",384,0.99999994,-0.08996372,-0.038809896,-0.00775749,-0.041471325,0.012505118,0.04022399,-0.10050767,0.035434593,-0.034784608,0.010895408,0.03681583,-0.09498598,-0.06726614,0.07186421,-0.03494035,-0.011687889,-0.021851724,-0.0035238112,0.024843194,-0.054231994,0.02408585,0.020711262,-0.028927771,0.0017937104,0.03306995,-0.016508065,0.10536137,-0.032636926,-0.0220996,0.007102474,-0.10730319,-0.01850475,0.04769811,-0.044942185,0.074321724,0.10258744,-0.051773068,-0.07964554,0.056622278,0.014598542,0.02830657,0.06841035,0.0033539562,0.022836728,0.012392988,0.040622354,0.051254015,0.04759365,-0.06043792,-0.07705473,-0.056171063,0.019133631,-0.036886275,-0.014506492,-0.043274805,0.036230218,-0.034621194,-0.040178448,-0.02430483,-0.035238028,0.014446308,0.0112651335,-0.012931359,0.0104235755,0.071165964,-0.026148329,0.042370904,-0.0076148785,0.017774079,0.028249085,-0.107322566,-0.04527672,-0.057836987,0.045153167,-0.043606028,-0.020406373,-0.010687701,-0.1303863,0.036815222,0.060669094,-0.0030753869,-0.018009827,-0.020566681,0.03228998,0.12011601,-0.0655803,0.019603904,0.021459717,0.022445407,0.03887773,0.017073283,-0.0055340747,-0.004376577,-0.002882205,-0.0916516,0.06083284,0.02333146,-0.0035375115,0.038119543,-0.05910753,0.00867512,0.07856445,0.047302045,-0.023064531,-0.03138713,0.0019391752,0.021293176,0.060519125,0.048153475,0.06121076,-0.001074048,0.05200561,0.0290733,-0.078701526,0.059610534,0.10645667,0.018102815,-0.053122494,0.016754974,0.09317788,-0.01771028,-0.06821039,-0.011766382,0.08587689,-0.03825673,0.026753355,-0.08309809,-1.7156107e-33,0.022534933,0.023427447,-0.009277998,-0.030244568,-0.0024283277,0.035340905,-0.056325562,-0.0011714685,-0.08380645,-0.10850828,-0.07208387,-0.074861966,0.035704434,0.016850084,0.004570765,-0.016428322,-0.00977591,0.0036625841,0.084597975,0.043370884,-0.033480432,0.033619847,-0.006991307,0.044547137,0.049976762,0.010971665,-0.0096877655,0.035329316,-0.022527885,-0.009293545,-0.017608412,-0.050456334,-0.100787535,0.035611097,0.015311996,0.010648585,-0.055422213,-0.0533478,-0.016761262,0.05392144,-0.0023084166,0.043824546,0.004556115,-0.019895297,0.058695704,-0.058002446,-0.045754477,0.08586963,0.02500717,0.017254695,0.08380232,0.0040780767,0.034111585,-0.064313926,-0.009535763,-0.008406313,-0.016208518,0.01751656,0.011840771,0.07408081,0.01154061,0.049472775,-0.06288207,0.11570611,-0.040261254,0.074709594,-0.07429638,-0.0764212,0.044464696,0.055240512,-0.10387331,-0.059846144,0.004831605,0.023544338,0.04600493,-0.024176233,-0.031591617,-0.01318652,0.04912111,0.034466296,-0.049986545,-0.031026846,-0.00828316,-0.0019104757,-0.024357881,-0.062848605,0.019363226,0.051586136,0.07802078,0.03394188,0.12088397,-0.030534226,-0.005966827,0.084217,0.05117547,-3.9035265e-34,0.072722144,-0.06277451,0.0026863632,-0.080495566,-0.057373583,0.051321927,-0.00703493,-0.17585771,0.027168216,-0.06778444,0.07033619,-0.06154208,0.0026461948,-0.005347516,-0.016632402,-0.0020724365,-0.002282765,0.09734255,-0.020444846,0.010151532,0.00855959,0.058955036,0.036833737,-0.0053983103,0.018560609,0.029502248,-0.07298356,0.10077678,0.0156722,0.016105393,-0.07257588,-0.0031213204,-0.040258825,0.014686415,-0.04444378,0.10211405,-0.044847105,0.036619652,0.047796436,0.053916443,0.061288524,0.07181229,-0.03996837,0.09406258,-0.0179334,0.032502346,0.012881063,-0.079673395,0.005806715,-0.02486504,0.03174439,-0.023744503,-0.019744974,-0.04567592,-0.036733367,0.08649254,-0.016415369,0.02525227,0.041075516,-0.0429758,-0.047136165,-0.014105188,0.047025498,0.023663003,0.072959125,0.043810368,-0.042255294,0.049480725,0.025754085,0.00057666836,0.0037757873,0.085583426,0.062393446,0.011662681,0.0073938426,-0.024857178,-0.092842445,0.03128362,-0.0023455236,-0.04519585,0.0086968355,0.04323732,0.004171321,-0.030305257,-0.07038148,-0.057545643,0.024105476,-0.0027594424,0.0150380405,0.028075626,-0.0098121185,-0.030747809,-0.043798625,0.028804177,0.07147327,-3.0843914e-08,0.011038816,-0.02717013,-0.011332034,-0.08619632,0.05498277,0.08019542,0.049571432,-0.01965547,0.09967452,0.02879359,-0.0184815,0.09766333,0.036728844,0.039605983,0.020262273,0.009508879,-0.08467359,-0.04141989,-0.025244959,-0.026825752,-0.07722879,0.009095002,-0.0999975,0.08260683,-0.03787046,-0.041879572,-0.013029025,0.06169421,-0.024599671,0.00347121,-0.029083056,-0.014917854,0.011548353,-0.019377444,-0.08976063,-0.002780091,-0.0025683255,-0.07795814,-0.08702418,0.016438453,0.0023414174,-0.020296859,-0.13416716,0.014815411,0.07578961,-0.025136324,0.020293862,-0.027441112,-0.031995744,0.00019478328,0.0704357,-0.058651794,0.028162578,-0.05567786,-0.015243472,-0.008989166,0.0032248835,-0.07762645,-0.08759797,-0.05186784,-0.027071962,0.026097335,0.19968395,-0.10493927 +6.3.2.6,Forms part of the purine biosynthesis pathway.,384,1.0,-0.014245846,-0.01268797,-0.11264818,-0.020168955,-0.008926914,0.07596525,-0.027700922,-0.04710238,0.028841,0.013051497,0.028747568,-0.073608994,-0.03184179,-0.07655668,-0.012747206,0.04085512,-0.17907166,0.016483502,0.09610151,-0.06379758,0.04527858,0.044000015,-0.07749937,0.0010435978,0.031437792,0.005121578,0.056106217,-0.009314117,0.025458362,-0.034831546,-0.033306506,-0.048544783,0.02123437,-0.02694262,0.06532052,0.11667761,-0.027423488,-0.014594432,0.068483956,0.00892699,0.037026085,-0.060601644,-0.041614246,0.045640923,-0.0009327698,0.0009552751,0.06152295,0.0020657566,-0.0013030742,-0.008673273,-0.025779761,-0.0068706935,0.0108974315,-0.009020326,0.0331735,0.017910065,-0.037890054,0.008141814,-0.006153275,-0.024332587,-0.020965245,-0.03385461,-0.051464245,0.0063543045,-0.010397273,-0.04643178,0.014667006,0.015294583,-0.007946862,-0.061207417,-0.007046438,-0.087258324,-0.010937433,-0.0017639856,-0.049629107,0.059989322,-0.024182089,-0.016654555,-0.025816219,0.0089518605,0.08325464,0.06752847,0.039153963,0.061556216,0.032856777,0.002866741,0.028174393,-0.0051176352,-0.037906025,0.039154164,0.0075472156,-0.08708308,0.07083756,-0.029574413,0.029707043,0.09470699,0.03732769,-0.04547187,0.108876675,-0.0783458,-0.050636914,0.08045983,-0.03620253,-0.03127425,0.047521275,-0.0049232715,0.008915486,0.06734079,0.0021078768,0.005783446,-0.061705444,-0.016547086,-0.025009423,0.040539786,0.02767181,0.06723544,-0.030364897,-0.047718428,-0.006098158,0.0046672733,-0.01692585,0.043834977,-0.049154785,0.10183,-0.08363734,-0.052103385,-0.07532465,-2.6555876e-33,0.078786515,0.07011628,0.01420961,-0.029155055,0.019849543,0.039388493,-0.051956307,-0.073778875,0.0078798365,-0.0048940964,-0.10074099,-0.14134699,-0.05003038,0.0026391845,-0.019027734,-0.08335315,-0.0544537,0.040448688,0.080021024,-0.02907998,-0.08608535,0.115542226,-0.0789414,-0.033690706,-0.01818508,0.027403267,-0.024046062,0.025833597,0.021280823,-0.030720238,-0.0023713661,-0.013515042,-0.00572809,0.024203064,0.05351065,-0.08790896,-0.017061263,-0.009015795,-0.0072852816,0.09451849,0.04416179,-0.020577248,-0.028537992,-0.016988155,0.04994219,-0.014133441,-0.07049504,-0.0080857705,0.049457923,0.076234505,-0.021658247,0.051899947,0.14994587,-0.018194139,-0.07416174,-0.014936198,-0.03501059,-0.06132351,-0.02828831,0.048800707,-0.0042887945,0.04016808,0.032142513,0.016514525,0.02551564,0.0065972,-0.101550415,-0.034340963,-0.0029134997,0.09308085,-0.033262093,-0.062970065,0.000278541,-0.089744404,0.09523142,0.02015449,-0.10891123,0.058521926,-0.069184825,-0.03232284,-0.06665981,0.04566246,-0.03945941,0.03367085,0.030500226,0.010345874,-0.0051734434,-0.04337956,0.034222107,0.0064691072,-0.025539616,-0.033479493,-0.056444786,0.018241871,0.016053563,-5.2275317e-34,0.047788214,-0.08590151,0.049671993,-0.0990566,-0.081477225,0.084727205,-0.0092158085,-0.037567202,0.07019289,0.15232456,-0.024191435,0.023100749,-0.036451146,-0.09874528,-0.0074260416,0.023951048,0.06720082,0.1482288,-0.03882156,-0.04239415,0.016370839,0.03493162,-0.016379124,0.05105065,0.04390552,0.0104854945,0.05037015,0.025211796,0.06059409,0.034676675,-0.010519297,-0.0051099677,-0.07967912,0.0070097684,-0.01650805,0.0010117837,-0.06930768,0.08753078,-0.052048005,-0.055158865,0.008050727,-0.0017023728,0.024800202,0.050821796,0.0783842,0.0022678936,-0.015359351,0.08256749,-0.026422074,-0.06860377,0.01770251,-0.012639388,0.060223743,0.025783082,0.032440238,-0.0018482796,0.0072318227,-0.006378196,0.047945894,-0.032444958,-0.0125418445,-0.021123871,-0.023310391,-0.02927657,0.062050823,-0.068090625,-0.022931803,0.039468873,0.015348444,0.013719068,0.048127618,0.0330072,0.03174519,0.06810311,-0.008465717,-0.015855528,-0.061631586,-0.10429318,0.04732228,0.008342503,-0.037511144,0.010687156,-0.0100430185,-0.06985373,-0.058756504,-0.040758602,0.020326708,0.059654936,0.041765492,0.044250548,0.013973181,0.03352922,-0.03737512,0.057786074,-0.057779405,-1.988349e-08,0.06384102,-0.05843866,0.03782267,-0.036724318,-0.020817988,0.00086306216,-0.005525809,0.05640392,0.07439883,-0.05792508,-0.045013614,-0.014996435,0.118287735,-0.0067086495,0.024740487,0.071597286,0.03727259,0.027556,-0.00050473533,0.007268999,-0.1051042,-0.03398719,-0.0872998,0.09463037,0.056543697,-0.05374538,0.049460642,0.060382605,0.0042929817,0.02225048,0.06285739,-0.0021841857,-0.017209243,-0.05188769,-0.0167072,0.016346416,0.018557318,-0.08551573,0.007901358,-0.024541285,-0.023016462,-0.04943569,0.021981517,0.035126783,0.0055517494,0.03969115,-0.005574408,0.037197083,0.026109478,-0.03172435,-0.05680808,0.012952033,-0.009218082,-0.0643159,-0.038316853,-0.025626592,-0.008616644,-0.086461954,0.03425487,0.0018170577,-0.022812162,0.08502458,0.19756736,-0.009020083 +6.3.2.7,"Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase) adds 2,6-diaminopimelate instead.",384,1.0,-0.057897292,-0.09237422,-0.09214381,-0.07640524,0.049095143,0.055697735,-0.0822526,0.11535806,0.046439305,0.04114055,0.050346244,-0.062305197,-0.033486627,0.054737832,-0.0061332057,0.030856106,-0.06437497,-0.00028190186,-0.03755637,-0.027091308,0.04656343,0.09468149,-0.063513614,-0.0331712,0.06298274,-0.051295094,0.08534629,-0.038084768,0.038167544,-0.036147486,-0.010961568,-0.061501972,0.059191834,-0.06648431,0.07924302,0.032668192,-0.031755567,-0.059523392,0.107094295,-0.010268986,-0.0068538697,0.0053048423,-0.0122582875,-0.04963268,0.03926244,0.011796295,-0.006168756,0.06768759,0.0501577,-0.052519776,-0.005609202,-0.024467781,-0.055843875,0.0381902,-0.0660652,0.026293859,-0.12969354,0.01123115,0.015522061,-0.016851475,-0.021217821,0.061296225,0.076844014,-0.04116153,0.01370567,-0.122991204,-0.008614932,-0.038270097,0.02461075,0.0019447096,-0.02062242,-0.11668858,0.061820444,0.052116487,0.049238734,0.006191708,-0.022730507,0.0030742893,0.026669504,-0.043819502,0.036115494,-0.049599744,-0.032050867,0.1307322,0.016464777,-0.0646349,0.02852518,0.017120086,0.0043932376,-0.018859437,0.07776606,-0.055530977,-0.014020411,-0.049054053,-0.062472373,-0.032006934,-0.02617095,0.012169803,0.048860304,0.039901722,-0.032079574,0.038906373,-0.045831364,0.005366108,-0.00606669,-0.0064740754,0.023904141,0.12195141,-0.0011733136,-0.05819006,0.03320545,0.035694707,0.048298404,-0.013183815,0.006301746,0.031309094,0.028501557,-0.080984555,-0.03699653,-0.018585691,0.07268767,-0.038139112,0.04334075,0.10308611,-0.07649714,0.08278625,-0.03774352,-2.1086346e-34,0.06773119,-0.018425237,0.037440013,-0.035780415,-0.00537614,-0.009648357,-0.057202373,-0.030114125,0.06243405,-0.019320568,-0.06847354,-0.09941717,0.08061651,0.09321348,-0.019530123,0.006594716,-0.026998688,-0.013979584,0.04699098,0.050886266,-0.024121474,0.015304778,0.048658177,0.010457315,0.072141975,0.013271149,0.035386123,0.0007842007,0.03003473,-0.00044656088,-0.07527316,-0.10372631,-0.051700655,0.03762778,0.05712862,0.01700542,-0.008237763,-0.118470274,0.06684885,0.0009589172,0.002417815,0.057459984,-0.04569945,-0.015812904,0.07488442,0.04716697,-0.022652548,0.053861238,-0.053138483,0.025170079,0.072857566,-0.020993488,0.041661367,-0.035526298,-0.02304609,-0.017159706,-0.059536766,-0.005949122,0.045028564,0.056156214,0.018191054,0.04461519,-0.03522232,0.021626355,-0.0254085,-0.0076047336,0.001278439,-0.06841264,0.022571987,0.009943718,-0.085588954,-0.018670123,0.05169519,0.05615347,-0.012875041,-0.04792223,-0.07455919,0.027924245,0.016329976,-0.039175782,0.0046588243,0.03078814,-0.03388472,-0.013015559,0.024394305,-0.015813924,-0.017720014,-0.10619713,-0.0029893261,-0.002882026,0.059034888,-0.046505157,-0.016526708,0.101328164,-0.045355998,-8.987773e-34,0.022521919,-0.09772944,-0.041965585,-0.06936587,-0.061583374,0.016707098,0.025494711,-0.005223071,0.061506182,-0.036327392,0.06635459,0.005606396,-0.01874256,-0.031158026,0.04551204,-0.0056431633,-0.02359804,0.059359673,0.00017428011,-0.01855915,-0.0009924808,-0.011239703,0.05174889,0.005812424,0.105585195,0.051209886,-0.07564982,0.09591809,0.02960964,0.009956439,0.008738213,-0.0069277124,-0.0135836415,-0.057065345,0.0026802607,0.073590145,0.02057008,-0.0130198905,0.01742494,-0.059721734,0.025556961,0.04238971,0.019533155,0.052427698,0.00014144504,0.053451158,0.009395909,-0.009906362,-0.021203509,-0.07961108,0.023641558,-0.0646281,0.061726503,-0.038041823,-0.033003706,0.013029836,0.025392922,0.076635845,0.032128405,0.011740895,-0.0157901,-0.077145934,0.0042082085,-0.037932217,0.036731433,0.048465278,0.02816678,0.041421004,0.06173802,-0.016841432,0.06530949,0.025018374,0.026440294,0.061930396,-0.021231843,-0.016068289,-0.04836023,-0.10163084,0.0712049,0.0027480568,-0.07273077,0.005559972,-0.028373796,-0.038699534,-0.0027466924,-0.06003821,0.029084345,0.15955243,0.00456574,0.06597704,-0.020709723,-0.055072326,-0.037080847,0.012188682,0.07590297,-4.594611e-08,0.14306533,-0.070517376,-0.014318472,-0.0667246,-0.0108572645,-0.031373933,-0.04209441,-0.0010864806,0.03596436,-0.015564884,0.024984289,0.100702584,-0.050916757,-0.039472718,-0.024016557,0.076790094,-0.0804467,0.052065227,-0.036747295,-0.027441613,0.007866593,0.032598328,-0.09072801,0.046853192,0.06707104,-0.09587882,-0.028503552,0.036655407,-0.011409436,-0.011702751,0.025876796,0.029599046,-0.0008652726,-0.016841762,-0.032512527,0.04811006,-0.06626574,-0.074937455,0.033432364,0.004124235,-0.0011595209,0.03024071,-0.08403585,-0.03341094,0.04563238,0.02288972,0.010132608,0.022181295,-0.09185803,-0.034182828,0.023411753,-0.056999803,0.019079125,-0.041619178,-0.11272055,-0.013257005,-0.06402858,-0.07761314,0.026108515,-0.049641937,-0.069292255,0.08367985,0.17910135,-0.015194667 +6.3.2.8,Involved in the synthesis of a cell-wall peptide in bacteria.,384,0.99999994,-0.025041146,-0.07407992,-0.12917383,-0.02869957,0.001453412,0.048801765,-0.061446328,0.11350403,0.08732019,0.05608881,0.042444777,-0.062364083,-0.03080719,0.04322727,-0.002762621,0.018873103,-0.045737438,0.05805734,0.05684819,-0.0064826356,-0.022999838,0.0814287,-0.0740299,-0.03692029,0.023324229,-0.004843193,0.06494468,-0.071933486,-0.015818132,-0.013291258,0.0021149067,-0.07277808,0.008962461,-0.039157752,0.07359646,0.04285499,-0.026886769,-0.05563561,0.11682337,-0.05427552,0.01587419,0.00404431,0.030803982,-0.040769905,0.06888248,0.06483079,0.03204882,0.052659392,0.06865155,-0.021765424,-0.039075334,0.01221829,-0.05314539,0.031142868,-0.040940993,0.029748004,-0.08427442,-0.0037365933,0.021810107,-0.06353238,-0.040568434,-0.022550667,0.13132381,0.003057635,-0.07804439,-0.10936326,-0.037881088,0.0018572493,0.022827486,0.009503969,0.010989088,-0.09383362,0.076263495,0.017664284,0.072146066,0.012275212,0.0025636586,-0.0050834436,-0.056619722,0.026204608,0.034878522,-0.007209006,-0.0009075232,0.13552468,-0.010353431,-0.02107504,0.08025255,0.018866329,0.00083095056,-0.023586366,0.09171834,0.0035139273,0.0006734127,-0.068242766,-0.059560817,-0.05572818,-0.021649195,-0.0062011606,0.05633609,0.007833603,-0.07288917,0.0065184175,0.014261186,-0.009232312,-0.002307755,-0.018001417,0.06683971,0.15699455,0.0152328275,-0.020649144,0.06843667,-0.02538031,0.003728874,-0.047179565,0.0042314194,-0.01748811,0.054111023,-0.07298884,-0.025591787,0.018922314,0.040573224,-0.018702013,-0.017598579,0.072514884,-0.12822545,0.024398532,-0.0035928353,-8.422708e-33,0.07663277,0.0002206165,0.048399687,0.017295223,0.008929689,-0.057791155,0.0453891,-0.088713564,0.08611655,0.035015285,-0.05711423,-0.095635496,0.034874193,0.09625705,-0.02435661,-0.0062784255,-0.015494523,-0.054685228,0.046924517,-0.030924242,-0.022262223,0.042397056,0.076640956,-0.02067872,0.04461698,-0.0026722974,0.031876832,-0.055215552,0.015561326,-0.04051527,-0.05480315,-0.02797153,-0.07544079,0.038247705,0.11319374,0.05375768,-0.009652082,-0.06804051,0.047934696,0.0071255895,-0.04499449,0.020146431,-0.005101835,-0.050343204,0.08467491,0.04303596,-0.054624625,0.02044736,-0.02593167,0.02601634,0.037193876,-0.0024805518,0.0014759221,0.02717001,-0.056511607,-0.038885955,-0.03748383,-0.013346804,0.0076617138,0.0086806,-0.079095356,0.017700871,-0.10333209,0.044381525,-0.03191208,0.008880283,-0.019921182,-0.022519479,0.019607479,0.003360483,-0.03462645,-0.03011257,0.05054287,-0.02134679,-0.026734332,0.019740881,-0.1157467,0.012461541,0.012496969,0.0010432785,0.021651566,0.033745583,-0.09968971,0.0015557391,0.0070981043,0.025496872,0.032568138,-0.06676563,0.044245746,0.009464031,0.043652553,-0.053711995,-0.03462527,0.05362419,-0.09129804,4.504641e-33,0.061162453,-0.14399952,-0.009343579,-0.057393268,-0.07650285,-0.004695221,-0.051686335,0.017829487,0.015778564,0.011565801,0.006812,0.05218428,-0.053845678,-0.0073690005,0.01617873,-0.027536243,0.009921013,0.038900066,-0.030917939,-0.012743385,-0.022633513,-0.007570418,0.01311139,0.00250302,0.06784452,0.060984615,-0.0022566246,0.116781496,0.104009345,-0.010186449,-0.015133907,-0.022892939,-0.021974321,-0.02002853,0.030312218,0.064674854,-0.01612903,-0.008205295,0.00982201,-0.10368301,0.008092786,0.016864669,0.010424871,0.036446273,0.07107225,0.067290924,-0.0017961073,0.050370928,-0.04144874,-0.088730134,0.013652346,-0.04879808,0.068166204,-0.08699237,-0.013692488,-0.022715896,0.0374477,0.07392051,0.05089966,-0.018652877,0.012955693,-0.085768156,0.1034431,-0.08317666,-0.004657625,0.069469124,0.009736955,0.037797283,0.032517806,0.022299197,0.0070879054,0.059701037,0.041913643,0.042615738,0.018324645,-0.0073258895,-0.05873332,-0.09542097,0.061777964,0.043735467,-0.09152059,0.006656179,-0.035962038,0.0030583946,0.066841364,0.012998837,0.022704763,0.081437305,-0.026083227,0.018275378,-0.02205985,-0.031899925,0.040847264,0.00989683,0.028707847,-2.0175454e-08,0.086161725,0.0009456359,0.013370616,-0.081600696,-0.03818552,-0.0025418971,-0.022228217,-0.07867169,0.026681826,-0.07701392,0.018712306,0.059846085,-0.023030642,-0.010750701,-0.019954376,0.108433,-0.0753871,-0.046109416,0.009826184,-0.045700032,-0.0714805,0.033175573,-0.098367155,0.07185974,0.044771664,-0.06255971,-0.004242888,-0.004560161,-0.022674453,-0.0029189282,0.026563525,-0.0009355266,-0.0062289843,0.018105116,0.034204334,-0.013317633,-0.09522211,-0.09087626,0.051483825,-0.035608247,0.040215686,0.089390494,-0.046346717,-0.022375649,0.00036280675,0.0011069855,-0.028981574,0.07057723,-0.12971447,-0.048709963,-0.0029085006,-0.034920074,-0.036532547,0.00065217173,-0.11727358,-0.02785964,-0.016338056,-0.088620074,0.013971594,-0.016593136,-0.029250061,0.009145542,0.12099063,0.051042173 +6.3.2.9,Involved in the synthesis of a cell-wall peptide in bacteria.,384,0.99999994,-0.025041146,-0.07407992,-0.12917383,-0.02869957,0.001453412,0.048801765,-0.061446328,0.11350403,0.08732019,0.05608881,0.042444777,-0.062364083,-0.03080719,0.04322727,-0.002762621,0.018873103,-0.045737438,0.05805734,0.05684819,-0.0064826356,-0.022999838,0.0814287,-0.0740299,-0.03692029,0.023324229,-0.004843193,0.06494468,-0.071933486,-0.015818132,-0.013291258,0.0021149067,-0.07277808,0.008962461,-0.039157752,0.07359646,0.04285499,-0.026886769,-0.05563561,0.11682337,-0.05427552,0.01587419,0.00404431,0.030803982,-0.040769905,0.06888248,0.06483079,0.03204882,0.052659392,0.06865155,-0.021765424,-0.039075334,0.01221829,-0.05314539,0.031142868,-0.040940993,0.029748004,-0.08427442,-0.0037365933,0.021810107,-0.06353238,-0.040568434,-0.022550667,0.13132381,0.003057635,-0.07804439,-0.10936326,-0.037881088,0.0018572493,0.022827486,0.009503969,0.010989088,-0.09383362,0.076263495,0.017664284,0.072146066,0.012275212,0.0025636586,-0.0050834436,-0.056619722,0.026204608,0.034878522,-0.007209006,-0.0009075232,0.13552468,-0.010353431,-0.02107504,0.08025255,0.018866329,0.00083095056,-0.023586366,0.09171834,0.0035139273,0.0006734127,-0.068242766,-0.059560817,-0.05572818,-0.021649195,-0.0062011606,0.05633609,0.007833603,-0.07288917,0.0065184175,0.014261186,-0.009232312,-0.002307755,-0.018001417,0.06683971,0.15699455,0.0152328275,-0.020649144,0.06843667,-0.02538031,0.003728874,-0.047179565,0.0042314194,-0.01748811,0.054111023,-0.07298884,-0.025591787,0.018922314,0.040573224,-0.018702013,-0.017598579,0.072514884,-0.12822545,0.024398532,-0.0035928353,-8.422708e-33,0.07663277,0.0002206165,0.048399687,0.017295223,0.008929689,-0.057791155,0.0453891,-0.088713564,0.08611655,0.035015285,-0.05711423,-0.095635496,0.034874193,0.09625705,-0.02435661,-0.0062784255,-0.015494523,-0.054685228,0.046924517,-0.030924242,-0.022262223,0.042397056,0.076640956,-0.02067872,0.04461698,-0.0026722974,0.031876832,-0.055215552,0.015561326,-0.04051527,-0.05480315,-0.02797153,-0.07544079,0.038247705,0.11319374,0.05375768,-0.009652082,-0.06804051,0.047934696,0.0071255895,-0.04499449,0.020146431,-0.005101835,-0.050343204,0.08467491,0.04303596,-0.054624625,0.02044736,-0.02593167,0.02601634,0.037193876,-0.0024805518,0.0014759221,0.02717001,-0.056511607,-0.038885955,-0.03748383,-0.013346804,0.0076617138,0.0086806,-0.079095356,0.017700871,-0.10333209,0.044381525,-0.03191208,0.008880283,-0.019921182,-0.022519479,0.019607479,0.003360483,-0.03462645,-0.03011257,0.05054287,-0.02134679,-0.026734332,0.019740881,-0.1157467,0.012461541,0.012496969,0.0010432785,0.021651566,0.033745583,-0.09968971,0.0015557391,0.0070981043,0.025496872,0.032568138,-0.06676563,0.044245746,0.009464031,0.043652553,-0.053711995,-0.03462527,0.05362419,-0.09129804,4.504641e-33,0.061162453,-0.14399952,-0.009343579,-0.057393268,-0.07650285,-0.004695221,-0.051686335,0.017829487,0.015778564,0.011565801,0.006812,0.05218428,-0.053845678,-0.0073690005,0.01617873,-0.027536243,0.009921013,0.038900066,-0.030917939,-0.012743385,-0.022633513,-0.007570418,0.01311139,0.00250302,0.06784452,0.060984615,-0.0022566246,0.116781496,0.104009345,-0.010186449,-0.015133907,-0.022892939,-0.021974321,-0.02002853,0.030312218,0.064674854,-0.01612903,-0.008205295,0.00982201,-0.10368301,0.008092786,0.016864669,0.010424871,0.036446273,0.07107225,0.067290924,-0.0017961073,0.050370928,-0.04144874,-0.088730134,0.013652346,-0.04879808,0.068166204,-0.08699237,-0.013692488,-0.022715896,0.0374477,0.07392051,0.05089966,-0.018652877,0.012955693,-0.085768156,0.1034431,-0.08317666,-0.004657625,0.069469124,0.009736955,0.037797283,0.032517806,0.022299197,0.0070879054,0.059701037,0.041913643,0.042615738,0.018324645,-0.0073258895,-0.05873332,-0.09542097,0.061777964,0.043735467,-0.09152059,0.006656179,-0.035962038,0.0030583946,0.066841364,0.012998837,0.022704763,0.081437305,-0.026083227,0.018275378,-0.02205985,-0.031899925,0.040847264,0.00989683,0.028707847,-2.0175454e-08,0.086161725,0.0009456359,0.013370616,-0.081600696,-0.03818552,-0.0025418971,-0.022228217,-0.07867169,0.026681826,-0.07701392,0.018712306,0.059846085,-0.023030642,-0.010750701,-0.019954376,0.108433,-0.0753871,-0.046109416,0.009826184,-0.045700032,-0.0714805,0.033175573,-0.098367155,0.07185974,0.044771664,-0.06255971,-0.004242888,-0.004560161,-0.022674453,-0.0029189282,0.026563525,-0.0009355266,-0.0062289843,0.018105116,0.034204334,-0.013317633,-0.09522211,-0.09087626,0.051483825,-0.035608247,0.040215686,0.089390494,-0.046346717,-0.022375649,0.00036280675,0.0011069855,-0.028981574,0.07057723,-0.12971447,-0.048709963,-0.0029085006,-0.034920074,-0.036532547,0.00065217173,-0.11727358,-0.02785964,-0.016338056,-0.088620074,0.013971594,-0.016593136,-0.029250061,0.009145542,0.12099063,0.051042173 +6.3.2.10,"Involved with EC 6.3.2.4 (D-alanine---D-alanine ligase), EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate---L-alanine ligase) and EC 6.3.2.9 (UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase) in the synthesis of a cell-wall peptide (click here) for diagram. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is meso-2,6-diaminoheptanedioate (acylated at its L-centre), linking the D-Ala-D-Ala to the carboxy group of the L-centre. This activity was previously attributed to EC 6.3.2.15, which has since been deleted.",384,1.0000001,-0.07156588,-0.095766336,-0.034265596,-0.06371145,0.05740055,0.070277974,-0.058259044,0.066410966,0.088475786,0.11616207,0.023398172,-0.068648495,-0.045150384,0.07263773,0.01335034,0.0067258705,-0.05342374,-0.046007156,-0.042377993,-0.031001559,0.025481664,0.07695021,-0.060172763,-0.055367153,0.08173495,0.016250871,0.10315659,0.026137559,0.036593,-0.08633693,-0.019798646,-0.10330365,-0.02082921,-0.02558058,0.03463752,-0.0018185078,-0.056859512,-0.062424645,0.041605975,-0.009950141,0.0030159967,0.05127891,-0.02428256,-0.06204662,0.07097992,-0.019187313,-0.041623514,0.062655814,-0.00015386783,-0.014890476,0.07185221,-0.053113993,-0.004089509,0.030501762,0.0072911936,0.06205264,-0.14021914,-0.0031876727,0.053484112,0.039604824,-0.0025123958,0.043239396,0.007849666,-0.06999248,-0.0651713,-0.06908321,0.056977443,-0.05771567,0.062155608,-0.012102261,-0.07774952,-0.11707905,0.032616958,0.024495173,0.053691823,0.01476364,0.025221027,-0.019339979,0.03712559,-0.06445486,0.03173169,0.011946094,0.033767067,0.055668756,0.031698976,0.01840483,-0.027193952,0.0021042963,0.042360567,-0.02417859,0.06145253,-0.062484354,0.007868182,-0.036373995,-0.020016983,-0.012099504,-0.0017093763,0.059769593,0.028493553,0.023859289,0.011385337,0.08169951,-0.06970669,-0.05809144,0.013456822,0.036791418,0.007948552,0.1369957,0.032234672,-0.068532474,-0.028126301,0.012296866,0.025825726,0.024361132,-0.055083215,0.07666118,-0.03601551,-0.06433459,0.017455386,0.0045619565,0.10857485,-0.013044738,0.020899925,0.07836814,-0.042829253,0.041677535,-0.06594557,-2.5584772e-34,0.06873863,0.046967812,0.010156648,-0.041032612,-0.002752031,-0.030871438,-0.07239824,0.063077904,-0.011374692,-0.0120849395,-0.06512547,-0.08867975,0.027187418,0.03984372,0.035275567,0.010715421,0.009827286,0.027276114,0.015800351,-0.01780765,0.032902163,0.012794426,0.01939538,0.029055238,0.05005562,0.024229184,0.013523226,0.055664457,0.045502897,0.008578361,-0.112048,-0.052036047,-0.037637774,0.013096062,-0.00040269815,-0.057216097,-0.058207583,-0.082153074,0.057413187,0.05495911,0.016692854,0.03971185,-0.075361,0.019330274,0.046953164,-0.023687419,-0.013202391,0.057062887,-0.012414115,0.023733547,0.085938,-0.017117875,0.10123829,0.0012013376,-0.05520691,-0.012020422,-0.1000378,-0.051887978,0.075463794,0.042592146,0.023175022,0.04406033,-0.02879766,0.026515054,-0.026847268,0.02585096,-0.021601181,-0.055225153,0.0014310352,-0.063311495,-0.03452665,-0.00769192,0.0885231,0.011691038,0.010818612,-0.06263499,-0.029281747,0.0704122,0.02404156,-0.072576106,-0.02938796,0.10344815,-0.018888423,0.0068602795,0.048744977,-0.044591013,0.026857806,-0.10821416,-0.037415948,0.008198704,0.041280538,-0.013137418,-0.028660394,0.065749675,-0.0115201995,-3.0612548e-34,0.04203473,-0.0491761,-0.033710085,-0.0680066,-0.055724666,0.02755295,0.075232215,-0.06734832,0.062119685,-0.12134285,0.039618652,0.009049116,0.004615873,-0.04340454,0.059681814,-0.04255479,-0.035538096,0.048275832,0.013463968,0.010853206,0.0629638,-0.043028716,0.00089536695,0.0013891045,0.096356794,0.016160507,0.0180873,-0.008129503,0.0612881,0.13220358,0.008679463,0.02030088,-0.037758432,-0.04173511,-0.005882578,0.10721454,0.021663917,-0.014363197,-0.0060019963,-0.0013464865,0.02605905,0.05778561,0.01492737,0.017835474,0.018099682,0.055966172,0.027281255,-0.0003248357,-0.06744322,-0.07486422,0.034317255,-0.051098898,-0.008384912,-0.009243522,-0.040128868,0.0505634,0.06670902,0.006054856,0.015734125,-0.01991664,-0.045668554,-0.042766254,0.017470585,-0.048499517,0.066972114,0.055798836,0.034172226,0.06565567,0.055788305,-0.04776506,0.024207016,-0.022600658,0.028700167,0.057772607,0.026496345,-0.04665607,-0.040458914,-0.046540573,0.044034075,-0.01059484,-0.048385058,-0.005362051,-0.004406201,-0.014360798,0.0028341368,-0.07873776,0.04214811,0.18359335,0.0132003585,0.06912923,-0.006980003,-0.05592048,-0.020631619,0.0981683,0.09942464,-5.846124e-08,0.13115604,-0.062489014,-0.027314272,-0.05966619,0.041653655,0.0018882022,-0.040864684,-0.015923439,0.026760468,-0.03516122,0.038100094,0.061104134,-0.032648,-0.032163553,-0.016663598,0.04450377,-0.06586687,0.059932005,-0.03231401,0.0057522464,-0.045022197,0.015932567,-0.07257788,-0.032861333,0.080796406,-0.12169303,-0.023284,0.052647304,-0.039318908,0.011793591,-0.03501825,-0.010944943,-0.02874225,-0.061555855,-0.009821529,0.027050395,0.00545069,-0.03392712,0.010823813,0.01892911,0.009822261,-0.048223514,-0.04896709,0.016002163,0.04457529,-0.004618696,0.008397001,0.03190686,-0.06612446,-0.021557068,-0.008462381,-0.062387224,0.018519353,-0.076237865,-0.11576174,-0.041675657,-0.096859075,-0.09363135,0.045717448,-0.07009011,-0.023846604,0.07232098,0.08814507,-0.033088464 +6.3.2.11,"This enzyme was thought to form AMP [1,2], but studies with highly purified enzyme proved that it forms ADP [4]. Carnosine is a dipeptide that is present at high concentrations in skeletal muscle and the olfactory bulb of vertebrates [3]. It is also found in the skeletal muscle of some invertebrates. The enzyme can also catalyse the formation of homocarnosine from 4-aminobutanoate and L-histidine, with much lower activity [4].",384,0.99999994,-0.0036859973,-0.017916474,-0.08670337,-0.023324134,0.0012953618,0.045343835,0.028748907,0.03904237,-0.038988817,0.0702519,0.04776178,-0.028064102,-0.07801939,0.10760836,-0.038550936,0.04371485,-0.0449686,-0.018824892,0.06923854,-0.016180549,0.038201682,0.048354387,-0.052962106,-0.0037904377,0.020386113,-0.05031058,0.03800855,-0.017049614,-0.032213632,-0.03452786,-0.0016940751,-0.08593163,0.035326965,-0.10118171,0.009494881,0.015818998,-0.06838841,-0.08060079,-0.005862733,0.07620537,0.0009847676,0.05440413,-0.04413506,-0.040881895,0.028808981,-0.04086652,0.001681682,0.032046806,0.03864504,-0.0014745463,-0.01548141,-0.0760195,0.076719224,-0.00029066904,-0.058047142,0.0031362134,-0.16302064,0.017540181,-0.017132262,0.010602428,0.04428009,0.035860743,0.016665747,-0.054110873,0.0470667,0.021206534,0.02868695,-0.044029392,0.012989832,-0.040821288,-0.0021446901,-0.056356877,0.005332181,-0.04455838,0.020570392,-0.0013190957,-0.06502109,-0.0163817,0.10393804,-0.05711429,0.03785023,-0.014202691,-0.08093196,0.02688118,0.0074545713,0.095243976,0.02395918,-0.039715037,-0.052665062,-0.00091478066,0.0070918463,-0.0776105,-0.05827324,-0.06493788,-0.020239666,-0.0090948455,0.018352706,0.07485186,0.05978583,-0.049271666,0.05718561,0.09115125,-0.0725671,-0.046457052,-0.08349153,0.072399765,0.009022021,0.089023136,0.016990164,0.029240115,-0.023561398,0.058631472,-0.00069266284,-0.029029217,-0.040414996,0.10277275,-0.027583728,-0.045935836,-0.084809795,0.056401964,0.03366758,-0.047073964,-0.0066112336,0.052851945,0.09102837,0.07142345,-0.033659663,5.2272305e-34,0.048949897,0.029969105,0.048331823,-0.0679237,0.053101707,-0.0338433,-0.072028466,0.052169207,0.014015609,-0.021629168,-0.13196021,-0.029049,0.07245483,0.024910696,-0.07202532,-0.0068271747,-0.026891146,-0.024335934,0.10978307,-0.0017807996,-0.009014872,0.10744462,-0.03206151,0.033434268,-0.010510946,0.009110295,-0.057601593,0.033694487,0.018484699,-0.00087493326,-0.009526702,-0.072331816,-0.1266346,0.017537232,0.042531006,-0.054737348,0.012429049,-0.06959211,-0.03171827,0.015630994,0.081691146,0.0111903725,0.05302411,0.0012998879,0.05219426,-0.043976083,-0.017873898,0.019023689,0.0821468,0.043462656,0.04944528,-0.029354334,0.09464145,-0.007268416,-0.09074117,0.057845905,-0.073813245,-0.078996286,0.036845326,0.10681644,0.002173359,0.075940266,-0.009258884,-0.016483903,-0.0867596,-0.014485918,-0.06315019,-0.108500466,0.03325072,0.02056108,0.0016044247,-0.07597975,-0.011987751,-0.0019339127,0.00033241365,-0.01029636,-0.00671908,0.090189874,0.0033906465,-0.06566488,-0.037502736,-0.060026776,0.04615783,0.034662,0.026185632,-0.0075253854,0.033756863,-0.06835159,0.02588258,0.11823422,-0.038696453,0.013113696,-0.09384401,-0.03706715,0.04930136,-2.947818e-33,0.08321638,-0.08618707,0.047767278,-0.055567205,-0.05770539,0.09763362,0.039522666,0.013893638,0.001965999,-0.04245159,0.053426396,0.006344672,0.06480441,-0.05599257,0.062942654,0.048094764,-0.039952468,0.05792336,0.012323093,-0.007711494,-0.05632096,0.07342337,0.08308348,0.062815845,0.0992688,-0.041104663,0.008982917,0.025112826,0.081839986,0.03877294,0.02040752,-0.017382247,-0.031829417,0.011242676,0.030744536,0.02460281,-0.012252294,0.04460511,0.029311098,0.03596134,-0.05456755,-0.015545975,0.03616211,0.07300882,0.028528605,0.05040641,-0.062576056,0.021402476,-0.07807102,-0.018788503,0.052431043,-0.003813326,0.01873727,-0.054084744,0.046450555,0.06922924,-0.004429365,-0.015940707,-0.0033618556,0.04705764,0.055532586,-0.0431247,-0.078210965,-0.026884472,0.0685994,-0.03071017,-0.044225644,-0.007864086,0.057056036,-0.031738285,0.029184336,-0.0033979497,0.018329825,0.0640346,-0.111479074,-0.012098936,-0.062037677,-0.043195073,0.099322036,-0.071268305,-0.026012821,0.030732978,0.04446699,-0.074672475,-0.03365328,-0.020025644,0.008081932,0.101427235,0.0008427619,0.039152995,-0.025782451,-0.011551668,-0.092662446,-0.0147558525,0.028477,-4.1528864e-08,0.0668584,-0.021437284,0.0322508,-0.06815436,-0.07657994,-0.01582484,0.055843562,-0.023103086,-0.007309198,-0.03099755,0.04177571,0.011964203,0.015720913,0.0012906946,0.014399842,-0.025108663,-0.010121863,0.07793309,-0.0774781,-0.0025480194,-0.04746001,0.016952775,-0.14169611,0.010396282,0.034240622,-0.046003707,0.047704685,0.11090353,0.017276635,-0.005546484,0.03080727,-0.0012898421,-0.020668436,-0.07439143,-0.0011930879,0.009175936,-0.031750288,-0.010094646,-0.04300248,-0.03162919,-0.06499941,-0.070838176,-0.028639346,-0.0054622483,-0.020575445,-0.025943352,0.04208873,0.01629533,-0.010349985,0.031595007,-0.0014071104,-0.011786323,-0.0031112717,-0.044076934,-0.09350254,-0.060793463,-0.06670693,-0.055041082,-0.026252665,-0.05141112,0.017302303,0.06928712,0.10379054,0.018101785 +6.3.2.12,"In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.17, tetrahydrofolate synthase [2], the combined activity of which leads to the formation of the cofactor polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates. In contrast, the activities are located on separate proteins in most eukaryotes studied to date [3]. This enzyme is responsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate and is present only in those organisms that have the ability to synthesize tetrahydrofolate de novo, e.g. plants, most bacteria, fungi and protozoa [3].",384,1.0,-0.05347583,-0.09278715,-0.0417176,-0.08896687,0.06200198,0.04353245,0.012323342,0.0191974,0.04275929,0.013663947,0.055367846,-0.10399538,-0.09076284,0.067148104,-0.054526065,-0.02534471,-0.11752327,-0.029997211,-0.009974634,-0.07408038,0.063531235,0.007321617,-0.086684495,-0.03752843,0.014729055,0.03398226,0.0052201278,-0.07991241,0.0422423,-0.057782102,-0.0010180715,0.036567792,-0.020000065,-0.039824232,0.031636562,0.12063102,-0.030617578,-0.08830964,0.11955428,0.029369744,0.06188634,0.0018462425,-0.022246297,-0.03909527,-0.08709108,-0.0003391858,0.096577436,0.040884677,0.009811893,-0.021108313,-0.028798558,-0.032556742,0.053735837,0.05220336,-0.014592097,0.030889094,0.07443942,0.022105642,0.02236556,0.030268937,0.02826957,-0.0059040175,0.029636126,-0.02659215,0.031992707,-0.056034084,0.029067457,-0.058435004,-0.007818889,-0.039565746,-0.08713596,0.051662255,0.006515731,0.09485545,-0.06797309,0.02132842,0.012525917,-0.026973238,-0.01642959,0.052472346,0.10304056,0.023882538,0.0058318474,0.0041881707,0.009340368,-0.08378649,-0.038860887,0.028666604,0.0460085,-0.000535841,0.056247357,0.008772281,-0.021640532,-0.035271287,-0.084620275,0.07305594,-0.0017318395,-0.005171129,0.09351396,-0.09358298,-0.016068239,0.009861036,-0.0016380361,-0.020326737,-0.016137335,-0.011933872,-0.010931691,0.047310144,0.010243296,0.06539717,-0.0116593195,0.0038013866,0.045786824,0.01349875,-0.06799959,0.06745003,-0.0147766955,-0.07662202,-0.060570862,-0.013763407,-0.025465418,-0.004020477,0.08991345,0.0029655986,-0.019551141,0.02704924,-0.17659913,3.0745213e-33,0.09364937,0.02253779,-0.022996113,0.0099189,0.057814155,-0.07874779,-0.045231104,-0.00081386254,0.020684883,-0.05232649,-0.067245625,-0.04612801,0.005381461,0.010396431,0.018296191,-0.005615877,-0.019900113,-0.016443605,0.0028214501,0.020125927,-0.0030328117,0.07759726,-0.050915476,-0.000318578,0.050622266,0.09107581,-0.017229423,-0.07603781,0.090076625,-0.006467735,-0.023220718,-0.13361621,-0.0856867,0.043208886,0.15904489,-0.073115654,-0.03650285,-0.010374557,-0.021281444,-0.0026279169,0.05817343,0.0124392435,-0.047278862,-0.08821979,0.07292276,-0.04100396,-0.018593559,0.04067484,0.022416608,0.005372203,0.07900302,0.0070643034,0.033878867,-0.016694885,-0.09126866,0.016217899,-0.05513348,-0.040630244,0.100377046,0.00829116,-0.045281116,0.06693113,-0.08652534,0.00071001105,0.0154259,-0.004968118,0.009952136,-0.033801123,0.03325508,0.057075683,-0.09635797,-0.044895835,0.058201566,0.003033283,0.04222921,-0.045948353,-0.07870504,-0.023300136,0.06883253,-0.039642554,0.014295092,0.045063104,0.071101494,-0.03807907,-0.090452224,-0.017971653,-0.0066503333,0.020717155,-0.054238275,0.018935166,0.054331753,-0.051936727,-0.016582385,-0.04995392,0.004675937,-5.0675837e-33,0.07635449,-0.05299486,-0.00720952,-0.0327737,-0.042187247,0.11326228,0.018471519,-0.025054375,0.04687862,-0.033977732,0.023866115,0.020842496,-0.020010266,-0.034306508,0.029362628,0.007385729,-0.034235273,0.09208765,-0.07242657,-0.064246744,0.03952552,-0.016694503,0.031809453,0.025749275,0.008383181,0.013612803,0.03398245,0.040911872,0.0136974,0.05454598,-0.011805425,-0.005224619,-0.025633086,-0.057307113,-0.055595826,-0.018274648,-0.08508121,-0.023274772,0.03388512,0.052691143,0.039140046,0.030309677,0.06404005,0.026048427,-0.03959455,0.03640558,-0.104980774,-0.00095689064,0.015771268,-0.02347733,0.046997447,0.008775402,-0.08584827,-0.07146656,0.062046554,0.010807234,0.08861052,-0.01667882,-0.06180366,-0.0030799306,-0.03736298,-0.085345626,0.04511122,0.0295019,0.04917819,0.055333663,0.03589599,0.08494417,0.03398847,0.0071755587,0.06125487,0.03188951,0.044661436,-0.009508253,0.036956456,0.026184417,-0.08334889,-0.018515676,0.0478017,-0.029995583,-0.012678043,0.010523374,-0.022725457,-0.077332474,0.030561106,-0.12477495,0.00505625,0.10472595,0.013720781,0.018961176,-0.009554118,-0.027463023,-0.0033948421,0.12267229,0.07927032,-4.7586514e-08,0.017685693,-0.021799656,-0.0073339706,-0.010630385,0.019195637,0.05752227,0.012418481,0.01871755,0.08164613,-0.068768255,0.01840633,-0.014029743,-0.005035707,0.08581596,0.03601466,-0.009702932,-0.051386625,-0.04776635,-0.044786215,-0.00219631,-0.02259166,-0.018261889,-0.11971651,0.029668013,0.049764525,-0.024110463,0.013124212,0.084464245,-0.031221848,0.018511664,-0.047051147,0.06875186,-0.060133584,-0.026300311,-0.048074156,-0.0043906122,0.0048889746,-0.012968234,-0.06313193,0.057280872,0.03968273,0.033273503,-0.08371355,-0.008531944,-0.002360029,0.029015867,-0.050725125,0.041056737,0.006398189,0.016378907,0.013422631,0.03197924,0.027392747,0.008573687,-0.103256546,-0.010726868,-0.062333178,-0.059421394,-0.02692443,-0.08272766,0.011465483,0.013394103,0.13358392,0.023654599 +6.3.2.13,Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) adds lysine instead. It is the amino group of the L-centre of the diaminopimelate that is acylated.,384,0.99999994,-0.048323695,-0.08739378,-0.1014214,-0.07227266,0.052190855,0.036808625,-0.03171503,0.1030995,0.026151514,0.014908763,0.043870702,-0.06153724,-0.03480321,0.06590064,-0.0067645083,0.035724107,-0.033554215,0.0020386202,-0.041699182,-0.045410544,0.041893963,0.08760165,-0.056064922,-0.035359852,0.06466391,-0.010035557,0.06744211,-0.025079701,0.052806545,-0.054509986,-0.03352488,-0.050895218,0.08651491,-0.058865745,0.08696291,0.03147095,-0.02522812,-0.05365563,0.07695152,0.016274007,0.028060451,0.035068702,-0.01227124,-0.025955537,0.029300993,0.029637855,-0.012906719,0.089920655,0.036395147,-0.05364735,-0.0105382325,-0.0351825,-0.06918722,0.051951792,-0.0883486,0.056107838,-0.0979286,-0.001136296,-0.003958561,-0.03734725,-0.02981815,0.057606436,0.059814133,-0.05337124,0.013763842,-0.1042269,0.01197449,-0.06378695,0.049746603,-0.0068411236,-0.008222863,-0.10602122,0.05676348,0.0758612,0.0650126,-0.022270378,-0.020289283,0.005994274,0.04937161,-0.05329508,0.06607605,0.011229884,-0.022411887,0.10277439,-0.00085255376,-0.030566283,0.013229745,0.023373315,0.016513608,-0.06683168,0.038691383,-0.048381343,-0.041234758,-0.037176646,-0.062027857,-0.029720366,-0.009188619,0.019434068,0.054062415,0.039787818,-0.023573034,0.034547042,-0.053345293,-0.0058113327,-0.049208276,-0.018081332,0.002526849,0.10946234,-0.017238284,-0.028602207,0.022433203,0.019173283,0.055747356,-0.0135039305,-0.010376752,0.011399604,0.034821827,-0.066664,-0.03164952,-0.028122962,0.053873967,-0.029721849,0.05327223,0.10057549,-0.056442086,0.07316452,-0.0546506,-7.99403e-34,0.05563324,-0.028938977,0.040081333,-0.03677429,-0.013473099,-0.014290416,-0.0676347,-0.009704444,0.08550505,-0.010242275,-0.07329568,-0.09649668,0.046266574,0.08793143,-0.028218282,0.00089799665,-0.019280726,0.021107333,0.017164223,0.047985487,0.004458869,0.05183791,0.022751309,0.01892119,0.059868984,0.012345076,0.027098732,-0.0008449996,0.055043772,0.0030737964,-0.040086843,-0.104620434,-0.062592424,0.0049684565,0.052634567,0.007987144,-0.008956411,-0.09356793,0.041679967,0.04816203,-0.05043547,0.073490694,-0.050194934,-0.031252597,0.05717826,0.026619507,-0.004534692,0.061662894,-0.05099916,0.00095996365,0.06886338,-0.028278518,0.040506992,-0.034648955,-0.03869022,-0.018443448,-0.048999783,-0.028063264,0.05908818,0.027043173,0.044289254,0.022490392,-0.043462515,0.004900425,-0.019471163,0.0028045748,0.0018356304,-0.04364539,0.032327235,0.03432943,-0.08804782,-0.051326837,0.04967438,0.1087374,-0.020466227,-0.07686326,-0.053812027,0.02091753,0.0074877916,-0.0654767,0.0014811946,0.017067162,-0.027586011,-0.033749226,0.0007377983,-0.015599771,-0.0034939358,-0.069940045,-0.020618098,-0.0033420436,0.051289223,-0.024862168,-0.014572269,0.077820994,-0.040861156,-1.7200677e-34,0.041320954,-0.10629777,-0.08442091,-0.04799124,-0.06057053,0.015461547,-0.005661126,0.03985761,0.06785365,-0.009517841,0.04016062,0.0313191,0.0067656077,-0.015725587,0.04418878,-7.462501e-05,-0.021732096,0.081522815,-0.041056246,-0.020079331,-0.02926952,-0.031317264,0.045501944,-0.01656361,0.08643634,0.04736696,-0.10351471,0.093591385,0.040375073,0.040640768,-0.01326172,0.004934744,-0.06133945,-0.0764945,-0.018528432,0.06981515,0.011476098,-0.0023573467,-0.024741918,-0.06497269,0.00272482,0.07040769,0.029145997,0.055320192,0.012303314,0.049244776,-0.01123816,0.00041645893,-0.022573937,-0.07178924,-0.004336628,-0.040787093,0.08936135,-0.04816268,-0.045410737,0.04557763,0.016064197,0.06937457,0.029434066,0.016299095,-0.012853674,-0.116555154,0.020332918,-0.018123684,0.055890292,0.07217118,0.029775415,0.06618297,0.06894843,0.008255668,0.059682827,0.040919833,0.018915165,0.06548149,-0.025170697,-0.010982894,-0.04067063,-0.06283592,0.06107121,-0.0038393554,-0.062527455,-0.010888538,-0.033761982,-0.023756715,-0.036389507,-0.045173824,0.019188117,0.1841688,0.0042427825,0.062136568,0.0010858283,-0.09107267,-0.0356151,0.047668796,0.06820189,-4.461065e-08,0.10877531,-0.037838645,0.0013528236,-0.052269466,-0.035617545,-0.026076054,-0.046464738,-0.016841399,0.06349732,-0.025983905,0.03133412,0.100575544,-0.057810113,-0.022626383,-0.02528283,0.11156833,-0.05873985,0.07214912,-0.027007485,0.0039597265,0.014014528,0.015715534,-0.09674853,0.04464858,0.06829359,-0.08682687,-0.0013020184,0.07665631,-0.02737367,-0.015383132,0.0057845893,0.047631025,0.011143297,-0.019131571,-0.03947702,0.041812472,-0.051823393,-0.040876444,-0.0033339828,-0.03769649,0.02666742,0.005791358,-0.052913222,-0.01862221,0.037681654,0.022119768,0.041184254,0.011827267,-0.08960751,-0.044630896,0.025640374,-0.04873581,0.001568616,-0.038224638,-0.14285676,-0.009289191,-0.08229475,-0.0935516,0.034116786,-0.060407817,-0.09737532,0.076519966,0.17782265,-0.00082764524 +6.3.5.11,"This enzyme is the first glutamine amidotransferase that participates in the anaerobic (early cobalt insertion) biosynthetic pathway of adenosylcobalamin, and catalyses the ATP-dependent synthesis of cobyrinate a,c-diamide from cobyrinate using either L-glutamine or ammonia as the nitrogen source. It is proposed that the enzyme first catalyses the amidation of the c-carboxylate, and then the intermediate is released into solution and binds to the same catalytic site for the amidation of the a-carboxylate. The Km for ammonia is substantially higher than that for L-glutamine. The equivalent reaction in the aerobic cobalamin biosynthesis pathway is catalysed by EC 6.3.5.9, hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing).",384,0.99999994,-0.003665707,-0.0026516935,-0.09901214,-0.08450078,-0.00028153142,0.06864629,-0.0426327,-0.01806294,0.016629212,-0.0069781765,-0.039480746,-0.08663421,-0.05530004,-0.059639484,-0.0641575,-0.015361662,0.0027589486,-0.06434642,-0.0013012976,-0.035918802,-0.0017970031,0.040776934,-0.031878434,-0.007457861,-0.010183909,0.019568352,0.0523787,-0.01928298,-0.009329925,-0.03232655,-0.052415617,-0.06367372,0.085638665,-0.007441753,0.016068703,0.10917689,-0.016021911,-0.038096372,0.09878095,0.025195155,-0.031103238,0.090304755,0.013628246,0.023149122,0.006169467,0.022051727,0.064318724,0.015304617,-0.004500651,-0.044615068,-0.021560991,-0.03494337,-0.027366122,-0.019173235,0.0061722742,0.038992524,-0.124974124,0.029276898,0.01508002,0.03877727,-0.070725426,-0.031772695,0.05413244,-0.05317162,0.06780845,-0.034778923,0.03146058,-0.05576652,0.05734644,-0.057041153,-0.08377929,-0.08417153,0.029573305,-0.04475583,-0.05707485,0.033568196,-0.026765393,-0.006275128,0.04818513,-0.02129958,0.059106193,0.017221266,0.036184017,0.010196101,0.036697537,-0.053919695,-0.007364605,0.052666817,0.0771867,-0.02576353,0.015712464,-0.029608354,0.05342858,0.009610801,-0.054339904,-0.034243334,0.020474147,0.053341713,-0.003369902,-0.04704552,0.021913467,0.13492133,-0.043551866,-0.04410759,0.013386354,0.009458011,0.054846916,0.18770437,0.050478414,0.075664885,-0.057826415,0.06246892,-0.016536621,-0.025704527,-0.077762805,0.07724752,0.048083846,-0.041230273,-0.11617867,-0.010500948,0.061944235,-0.06640053,0.022312831,-0.00734154,-0.031493656,0.002695387,-0.027402645,4.436014e-33,0.07148885,0.048785083,0.016029779,-0.02151671,-0.035535596,-0.020704225,-0.106160425,-0.013916962,0.05705523,-0.089261465,-0.022588419,-0.02535608,0.030316006,-0.01833247,-0.07732679,-0.030918077,-0.076748915,-0.059722792,0.026803445,0.015120556,0.00596909,0.085426316,-0.029270846,0.06498503,-0.019932993,0.028787902,0.024630304,0.048930436,0.055332083,-0.02094715,-0.008494088,-0.080374636,-0.06943968,-0.004988946,0.005958841,-0.030315857,-0.088181406,-0.010803472,0.03588988,0.067513056,-0.04413168,0.014691215,-0.0124748675,-0.03385066,0.041255295,-0.032923173,-0.007967161,0.10306656,0.00505656,0.041368343,-0.0016985466,-0.014801637,0.08845075,0.031155106,-0.06536532,0.039736327,-0.046735678,-0.06569021,0.02008988,0.098262645,0.03379203,-0.005191431,0.034162536,0.028923683,0.002122013,0.02579281,-0.10250449,-0.03663171,0.054928128,0.09000643,-0.009558166,-0.08236302,0.038524378,0.13365436,-0.013990892,-0.02025084,-0.0120497355,-0.032596074,-0.030114865,-0.06299527,0.054439534,0.026152194,0.04966901,0.04011604,-0.0073197517,-0.02303154,-0.02537467,-0.018321622,-0.019819167,-0.013408638,-0.048170723,0.011583081,0.029471435,-0.00048427025,0.020020377,-4.2971394e-33,0.15847002,-0.05393876,0.0010010733,-0.053931598,-0.029250132,0.030118031,0.054153815,-0.12331801,-0.0104812225,0.0077733384,0.025648851,-0.004577189,0.05473333,0.019455163,-0.038839266,-0.015779028,0.008058607,0.08490946,-0.081384294,-0.027002426,0.051423322,-0.001933147,-0.017323159,-0.02708878,-0.0005048522,0.065869816,0.021464184,0.029734395,0.055010404,0.06521939,0.015708847,-0.0052907374,-0.0051462385,-0.067200586,0.008049272,0.065709546,0.015290473,-0.036874466,-0.077703096,0.026827104,0.006031224,0.02476315,-0.0052213455,-0.0057866084,0.04417708,0.05940997,-0.072584674,0.013375688,-0.047595624,-0.027710631,0.011366843,0.025725104,-0.039127886,-0.02104406,0.06538892,0.070246086,0.038445763,-0.038594753,0.050409272,-0.04996463,-0.019468168,-0.040565576,0.014457149,-0.06955933,-0.0031554103,-0.030585993,0.016502397,0.050691415,0.043138783,0.039607722,0.013042818,0.05356713,0.10766933,0.06215937,-0.061739393,0.018377436,0.030822821,-0.09973948,0.029851995,-0.09725793,-0.013754627,-0.03536055,0.09408497,0.009383794,-0.03724508,-0.022634855,0.061344065,0.0508955,-0.03658911,0.045229774,-0.009517119,-0.08294963,0.0096763,0.06810752,0.015421131,-4.3674987e-08,0.055954047,-0.06959668,0.01573991,-0.0072384514,-0.019454744,0.15231042,-0.061400667,-0.054775536,0.028680066,-0.090877414,0.014146009,0.052400522,-0.013577787,0.02563116,-0.104819536,0.011516213,-0.06940102,-0.00034738713,-0.029825132,0.059858456,-0.095370285,-0.0033112294,-0.08385899,0.0127678495,0.08510142,-0.06996349,0.008627881,0.07833934,-0.03215375,-0.02381609,-0.024864022,0.034539882,0.10947914,-0.08298519,-0.043363895,-0.012178891,0.0026062855,0.037013132,-0.024970213,-0.043390784,0.032124598,-0.018263886,-0.0516833,0.046726838,0.07624108,-0.0036942882,0.00797841,0.05439098,-0.06923001,0.060292974,0.089153334,-0.017659698,0.036518015,-0.023904653,0.0015813846,-0.008906711,-0.1116145,-0.08446836,0.047043044,-0.034571245,-0.021688024,0.023673758,0.10394598,-0.0634885 +6.3.2.14,"This enzyme complex catalyses the conversion of three molecules each of 2,3-dihydroxybenzoate and L-serine to form the siderophore enterobactin. In Escherichia coli the complex is formed by EntB (an aryl carrier protein that has to be activated by 4'-phosphopantetheine), EntD (a phosphopantetheinyl transferase that activates EntB), EntE (catalyses the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB to form the covalently arylated form of EntB), and EntF (a four domain protein that catalyses the activation of L-serine by ATP, the condensation of the activated L-serine with the activated 2,3-dihydroxybenzoate, and the trimerization of three such moieties to a single enterobactin molecule).",384,1.0,-0.03596114,-0.08467601,-0.06954617,-0.06682122,0.059793986,0.021622702,0.014702713,0.057121202,0.010656323,0.015106471,0.007113882,-0.042849615,-0.05676044,0.048718095,-0.0039962814,0.01245218,-0.082097776,0.052331343,0.014054748,-0.042216443,0.08584632,0.005901528,-0.026141638,0.01612886,-0.029439803,0.01564079,0.020449588,-0.028369905,-0.05324626,-0.065014556,-0.0012085737,-0.019952334,-0.042855978,-0.044352394,0.051630218,0.025569418,-0.010870654,-0.08447989,0.04341078,-0.06447416,0.06549695,-0.0007692723,-0.024865966,0.005504355,-0.029922193,-0.03947607,-0.03181746,0.028912662,0.052812442,-0.093496196,-0.03828988,-0.0077440687,-0.052255053,0.062751375,-0.010606553,0.04755039,-0.040197484,0.022653494,-0.0037419924,-0.00020832289,0.022005597,-0.003990848,0.025328184,0.0021905694,0.05836163,-0.065534,0.017842816,-0.023440873,-0.043639984,-0.020954961,-0.058258284,-0.042337928,-0.10251004,0.06459739,0.021617385,0.015512415,-0.03493303,0.05650796,-0.042037528,0.016561747,0.08771355,0.051222946,0.034327544,0.07660084,0.01606487,-0.057459354,0.0005141441,0.0725784,0.13115342,0.08168154,0.0149782,-0.06856947,-0.014841061,-0.033543505,-0.04524589,-0.0090719415,-0.03397353,0.038678613,0.019534104,0.031276256,0.01402591,0.07368286,-0.0018118139,-0.100299604,-0.0012948497,-0.0072056907,0.081039906,0.1266768,-0.015534337,-0.029531803,-0.08032388,-0.044458386,0.13410234,0.0027405042,-0.033222552,0.0830497,0.053167526,-0.024583954,-0.002359957,-0.04840277,0.045763012,-0.00531054,0.09813984,0.004063084,-0.059987713,0.079939686,-0.13410811,4.8218903e-33,0.06521031,-0.014138795,0.0660254,0.07818777,-0.044857223,0.04857995,-0.0822358,0.02805639,-0.06211656,-0.027718136,-0.07042626,-0.08309534,0.101150975,0.026620848,-0.003260879,-0.03783001,-0.094191045,0.063721396,0.067790315,0.0353113,-0.004161279,0.07227282,-0.035267554,-0.011618791,-0.02070599,-0.010741803,-0.035073344,-0.0076672845,0.031727612,-0.0068912474,0.030078577,-0.050166752,-0.06817293,-0.008797415,0.055006668,-0.034488622,0.034058496,-0.054479785,0.07459186,-0.05532248,-0.019389061,0.006854107,-0.03138656,-0.01653146,0.019966844,-0.061067797,-0.03400505,0.06509663,0.024741445,0.059319057,0.071023494,-0.07049333,0.039129306,-0.09556673,-0.04273127,0.0471501,0.019123152,0.026872884,0.032483485,0.047120135,0.0066919266,0.017240288,-0.024687339,0.02350618,0.008515502,-0.012170982,-0.03528875,-0.07141738,-0.0052532176,0.06641338,-0.11568299,-0.026863964,0.08257917,-0.018393902,0.07217205,-0.078546464,-0.046560477,-0.01766648,-0.017283471,0.03030472,0.012613349,-0.02205305,0.0074582226,0.0032133942,-0.00079732103,-0.04932232,-0.05735884,-0.03442834,-0.051825035,0.022539588,0.054935507,-0.018461134,-0.042321477,0.04700837,0.055264715,-5.672432e-33,0.08765732,-0.056471203,0.034403298,-0.11228855,-0.07299669,0.044958062,0.033885553,-0.00816069,0.06686796,0.022105051,0.08192479,-0.04069672,0.04939665,-0.08531013,0.007845498,-0.06993617,-0.01524913,-0.05828865,0.0028015757,-0.04695883,-0.0021486725,0.03739769,0.038287617,0.048152976,0.027285395,0.079588026,0.009229679,0.13402456,-0.021636738,0.038544375,-0.037349083,-0.0762981,-0.008402583,0.028025143,-0.11870716,0.08094529,0.016124452,-0.03517295,-0.008682192,-0.045199413,-0.03432769,0.060441807,0.033459287,0.0063772765,-0.016134255,0.061701324,-0.05264882,0.0027198244,0.02391836,-0.04260826,0.011595144,-0.019722959,-0.014840802,-0.020559425,0.011331478,-0.00018088186,-0.0071573155,-0.033083756,-0.06974464,0.051670864,-0.0017010956,0.007406066,0.051867697,0.014481587,-0.017346265,-0.020836808,-0.0515127,0.008947341,0.047233004,-0.079131044,0.023994828,0.060991272,0.0012973961,0.03593873,0.072089605,-0.029010367,-0.022638602,-0.05402102,-0.038296904,-0.065996654,-0.036218498,-0.011638906,-0.059683215,-0.06811117,-0.011939785,-0.07843052,-0.009053663,0.1014337,-0.030512886,0.034891907,-0.029497173,0.04015001,0.017022315,0.127115,0.08119589,-4.9418624e-08,0.030934485,-0.09007053,0.00061065087,-0.026296956,-0.092069544,0.026093211,-0.0024553628,-0.00928683,0.07393738,-0.08282242,0.038909543,0.064444296,-0.016429527,0.045843177,0.082593784,0.04130643,-0.05880825,0.0065710633,-0.045248352,-0.035957355,0.00895871,-0.050647948,-0.077320926,0.06853065,0.05890023,-0.048174605,-0.025942849,0.048923187,0.005310434,-0.002380142,0.008463473,-0.024308445,0.013962567,0.01892922,-0.036215566,0.03446789,-0.096979484,-0.053959183,-0.006513223,0.046067324,0.00090618106,0.06296068,-0.14362478,-0.009530327,0.028683688,0.08459362,-0.011276597,0.0943677,-0.051287346,-0.041055407,0.02732282,-0.0139840385,0.031821262,-0.033818763,-0.097332135,0.074368775,-0.035778444,-0.053335186,0.058970112,-0.010716572,-0.008931673,0.045697473,0.14667499,0.03604013 +6.3.2.16,Involved in the synthesis of teichoic acids.,384,1.0,-0.004494213,-0.023969091,-0.10174478,-0.008033648,0.050377212,0.118600875,-0.084492885,0.039602865,0.0649443,0.021669855,0.07562812,-0.12275142,-0.009721649,-0.059033956,-0.04716407,-0.03322374,0.011025535,-0.006032671,0.014049515,-0.048259635,-0.07306805,0.039072976,-0.0007962966,0.011947739,-0.021665106,0.08590913,0.050544713,-0.016696038,0.011037784,-0.015176997,0.034031123,-0.048242133,0.047082897,-0.050388034,-0.0064873495,0.0065820734,-0.06863148,-0.020671116,0.06287957,0.042300902,-0.05506133,-0.027217971,0.023088535,-0.02836868,-0.035043065,-0.042983413,0.027712105,0.059530485,-0.0064692833,0.029546438,-0.03134762,-0.0032335925,-0.04817322,0.022553474,-0.036565945,0.076930895,-0.010504996,0.07070423,-0.010747838,0.04171213,-0.021574179,0.011351886,-0.007248705,-0.020038828,-0.044351622,0.046715647,0.030771846,-0.082288854,0.058821782,-0.011562777,-0.023472527,0.006764156,0.08390447,-0.024216305,-0.035038657,0.02809125,0.054683812,-0.0615056,0.0069162725,-0.011076709,-0.0025015231,-0.061063103,-0.10885348,0.027055508,-0.011027813,0.019804636,-0.044142667,-0.05203554,0.09578062,0.031465534,0.07599134,0.03530334,-0.011319297,-0.049246766,-0.046208333,0.05360931,-0.022165744,0.023218801,0.056870416,-0.07090877,0.018193914,0.07021271,-0.07796211,-0.09762629,-0.08542968,0.034575667,-0.032624308,0.12041137,-0.053313535,0.023615168,0.06937255,-0.05458426,0.041034564,-0.044375148,0.0015165342,0.026441086,0.0037061628,-0.08447218,-0.062754564,-0.0059179203,0.014943166,-0.015363698,0.004086712,0.065176494,-0.023615763,-0.05150993,0.015927782,-4.424146e-33,0.16134587,0.03383256,-0.043248184,0.022740314,0.008591849,0.041593492,-0.06837997,-0.031652,-0.040446784,-0.001375169,-0.047531527,-0.03427502,0.016697044,-0.043695293,0.017435724,-0.0071482575,-0.04880146,0.014878674,0.06930846,0.005739425,-0.038099464,0.12201423,0.03875185,-0.003741626,-0.0453257,0.144705,0.008395881,-0.07456273,-0.025436139,-0.0038147843,-0.022718966,0.050684046,-0.101197526,0.009205215,0.110525906,0.021936532,-0.11798034,0.037972715,0.042907994,0.052694038,0.088655084,0.025048256,-0.009500263,-0.00013130077,0.05903167,-0.0049956553,0.020421516,0.08312696,0.056509066,-0.011175807,0.06457834,-0.002708187,0.07041049,0.06070981,-0.06090427,-0.021543577,-0.04943227,0.012740418,-0.011849751,0.028897319,0.004653159,0.06738667,-0.037596438,0.06772949,-0.087131485,-0.06197365,-0.033023413,-0.028234484,0.045453597,-0.04551819,0.023034543,-0.04954759,0.11884065,0.024758313,0.024872364,0.025295697,-0.082343325,-0.01456806,0.024709476,-0.021408167,0.019868115,-0.03942627,0.0073192376,0.015751168,-0.047419757,0.026038812,-0.029379282,0.03319785,0.018852744,0.015643952,-0.021551244,-0.05314118,0.0009582189,-0.009594541,-0.018454075,1.6440697e-33,0.05719951,-0.09156832,-0.013873502,-0.08097798,-0.04487359,-0.031821366,-0.053411994,-0.050849956,0.0013317174,-0.018695569,0.056882452,-0.036191575,0.042686988,-0.09163803,-0.026974605,-0.039341763,0.074256115,0.0662683,-0.02968466,-0.13264896,0.036136165,-0.05398234,-0.023767807,0.022736166,0.040492017,0.08385382,0.05964573,0.0018195154,0.05049306,0.10805562,0.008437926,0.013084916,-0.054430645,0.04285515,0.025029628,0.11675124,-0.045510832,0.030012388,0.096771546,0.042566057,-0.0027421978,0.0027717291,0.085891046,0.004849119,0.049542017,0.050702583,-0.01067708,-0.04903183,-0.08626422,-0.04223336,0.08449478,-0.051742792,-0.02879925,-0.08564929,0.013438787,0.04359054,-0.049868613,-0.04294661,0.05670873,-0.07362688,0.009843417,-0.025985848,-0.0055551534,-0.07380995,-0.06393668,0.025524609,0.004711639,0.044776753,0.087410115,-0.0038233513,0.003995319,0.02268498,0.06873446,0.034767654,0.084700316,-0.08165145,-0.04175024,-0.016062187,0.016733931,-0.07369608,-0.0839457,0.0021156622,0.036664795,-0.02562677,0.011370134,-0.0018757792,-0.014553292,0.021578154,-0.002171087,0.028801741,-0.06730115,0.067494296,0.0046429974,0.09441064,0.115850486,-1.749816e-08,0.04903049,-0.047284894,-0.0062461225,0.024640642,0.0053653317,0.06337055,0.019336142,0.040461924,0.006154276,-0.053622376,-0.00979704,0.035189874,0.0263186,0.09799266,-0.04006609,0.024900895,-0.055763688,-0.062122975,-0.019778235,-0.041346975,-0.030573169,-0.005600957,-0.0467077,-0.05352013,-0.03469097,-0.00076191133,-0.05061361,-0.06403045,-0.05164075,0.03380694,0.024503747,-0.053392377,-0.018866498,-0.049176775,0.049573787,0.016252976,0.008288444,-0.05407031,-0.028225282,-0.07009252,-0.052798685,0.07071088,-0.09110956,0.057541315,0.06367923,-0.0559527,-0.08719024,0.096126966,-0.03768859,0.049000103,-0.04256194,0.0029511002,-0.0076388107,-0.028320845,-0.02117989,-0.077028394,0.022082279,-0.0782534,-0.01861157,-0.036013275,-0.003375776,0.047406755,0.0798073,-0.06425197 +6.3.2.17,"In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.12, dihydrofolate synthase [3], the combined activity of which leads to the formation of the cofactor polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates (H4folate). In contrast, the activities are located on separate proteins in most eukaryotes studied to date [4]. In Arabidopsis thaliana, this enzyme is present as distinct isoforms in the mitochondria, the cytosol and the chloroplast. Each isoform is encoded by a separate gene, a situation that is unique among eukaryotes [4]. As the affinity of folate-dependent enzymes increases markedly with the number of glutamic residues, the tetrahydropteroyl polyglutamates are the preferred cofactors of C1 metabolism. (reviewed in [5]). The enzymes from different sources (particularly eukaryotes versus prokaryotes) have different substrate specificities with regard to one-carbon substituents and the number of glutamate residues present on the tetrahydrofolates.",384,1.0,-0.05750137,-0.084730364,-0.104041904,-0.064135455,0.09338679,0.06681208,-0.041096568,0.028895266,0.08379718,0.0016572061,0.07727358,-0.08805798,-0.06727992,0.046310563,-0.057219975,-0.01808496,-0.115920335,0.00603583,-0.041008636,-0.06677689,0.011087859,-0.016018976,-0.07220613,-0.0043893782,-0.002178502,-0.04134602,-0.033678394,-0.08749173,-0.037756827,-0.04562489,-0.047409397,0.028452719,0.022343397,0.0046912762,0.030725298,0.14429207,-0.0101745,-0.102225415,0.059019852,-0.0027948006,0.057925254,0.016278813,-0.054992966,0.015831089,-0.11327388,0.02695567,0.10485386,0.021097431,0.03935653,0.0113860555,-0.018424097,-0.010779016,-0.0016235037,0.04224992,-0.018216785,0.033697546,0.05220364,0.015612455,0.027478922,0.03802088,-0.014961552,-0.038740564,0.011236963,-0.018352535,0.03394546,-0.061774354,0.032460634,-0.07757696,-0.037033632,-0.050314758,-0.047469944,0.026120111,-0.040267132,0.06944921,-0.08066363,0.04903223,-0.025793865,0.00082826265,-0.05103622,0.04024717,0.06102556,0.051653784,0.05187398,0.030641053,0.029417606,-0.10712228,-0.04388718,0.033185147,0.05264138,0.019081455,0.08437247,0.051710375,-0.02481661,0.014286693,-0.06336414,0.05817406,0.07727811,0.009470645,0.053676862,-0.082830705,0.010139195,-0.008748816,0.009731592,-0.017271498,0.0074733915,0.01708257,-0.019728307,0.05630504,-0.0058439956,0.023832476,-0.007132049,0.016700936,0.014335032,0.023020206,-0.03652186,0.08165716,-0.00086585636,-0.08130742,-0.014180975,0.0074632177,-0.021374863,-0.006607623,0.1133916,0.016092328,-0.033745512,0.02084866,-0.17971262,3.6940928e-33,0.08792295,0.05903859,-0.028395286,0.027269423,-0.011437466,-0.058918655,-0.055115264,0.03439945,-0.021076135,-0.038218632,-0.060903,-0.017430168,0.021364514,-0.036909062,0.013685038,0.007370413,-0.033136427,-0.04892693,0.042611893,0.025646567,-0.021638742,0.04766554,-0.04385833,-0.03712839,0.030107394,0.050387442,-0.001978202,-0.06787452,0.035762005,-0.0057754284,-0.016126795,-0.1333856,-0.06331925,0.027317876,0.14502372,-0.036292955,-0.07355642,0.017253308,-0.071044564,-0.004044884,-0.0059367153,-0.0010323545,-0.01888343,-0.13200597,0.09291966,-0.04519721,-0.013302891,0.038243603,-0.011203303,0.04439955,0.06319342,0.013315621,0.085466325,-0.012120158,-0.0809856,0.026991796,-0.037219502,-0.04025023,0.03510111,0.068446234,-0.0136101,0.063569635,-0.040712252,0.031895313,0.015052506,0.054011922,-0.101403676,-0.06560956,0.0028782496,0.08031719,-0.058893725,-0.056209147,0.12470344,0.030271377,0.06505548,-0.012676583,-0.04317355,-0.002791645,0.0054173004,-0.019924328,0.024340218,0.022311388,0.047788598,-0.010937005,-0.12600861,-0.012218346,0.026743079,0.016244082,-0.050621666,0.0061931834,0.09637159,-0.072266795,-0.024522534,-0.029590426,0.013180436,-5.1853418e-33,0.087952234,-0.07441048,0.023698583,-0.11566179,-0.025979282,0.10581821,0.024505693,-0.0675557,0.03865729,0.0058968677,0.047885366,0.007875534,-0.059812475,0.0030424583,-0.0017189909,0.022756921,-0.0050443476,0.0901718,-0.06616014,-0.014778271,0.0028031797,-0.0014552225,-0.007463651,0.018486919,0.0127828345,0.024930803,0.013294039,0.056983113,0.010243729,0.024922708,-0.04308277,0.032483507,-0.0017042368,-0.018698772,-0.029309575,-0.034991514,-0.11822193,0.0011865085,0.077039465,0.069980755,1.1248256e-05,0.036635287,0.03968543,0.009141616,-0.0013179441,0.036765676,-0.1233944,-0.013904296,-0.02231451,-0.0108147655,0.0023473452,0.018986002,-0.0743511,0.0046134973,0.06648153,0.030429436,0.06817382,0.03463263,-0.05451178,-0.028273612,-0.020227404,-0.050430275,0.022185745,0.028047998,0.062329903,0.024574993,-0.009774061,0.041831672,-0.014861858,0.06480778,0.03129858,0.0054476494,0.06808742,-0.019738536,0.025996609,-0.005338822,-0.02946509,-0.051140063,-0.02931086,0.011089105,-0.0243587,-0.010556493,-0.017891567,-0.06055696,-0.015085146,-0.10240426,0.023138678,0.10271982,0.030527918,0.003257737,0.03617905,-0.046414416,-0.016491693,0.11568932,0.1212099,-5.25195e-08,0.0050745006,0.00608022,-0.01618444,-0.035423245,-0.029100819,0.057989143,0.009949221,0.022086391,0.033396274,-0.01800479,0.00022024714,0.015316736,-0.004610083,0.040987197,0.028393306,0.0014054285,-0.06238536,-0.05842209,0.007933045,0.090384305,-0.025276884,-0.010055047,-0.13216278,0.03388744,0.016213672,-0.05408832,0.0002416995,0.06190758,0.00681291,-0.0051773647,0.007764797,0.0571549,-0.017487077,-0.06583164,-0.0995777,0.0087769255,0.013091843,-0.04654464,-0.054745074,0.08988849,0.052143045,0.029233152,-0.102879554,-0.007138738,0.062265214,-0.009356361,-0.020510582,0.023529636,0.039051823,0.07177348,-0.02156325,0.04052016,-0.011091984,-0.0053224936,-0.037541695,-0.007024373,-0.052983567,-0.050132155,-0.033969603,-0.0494466,0.021716861,-0.0036222797,0.13369407,-0.02447702 +1.1.3.49,"Contains FAD. The enzyme, characterized from the millipede Chamberlinius hualienensis, is segregated from its substrate, which is contained in special sacs. The sacs are ruptured during defensive behavior, allowing the enzyme and substrate to mix in special reaction chambers leading to production of the defensive chemical benzoyl cyanide.",384,1.0,-0.030953823,-0.069056295,-0.01796932,-0.020514887,0.08761822,0.00392865,0.0007350755,0.037057854,0.008657188,0.0016256957,0.03138908,-0.069977306,-0.076234944,0.09060528,-0.13373673,-0.042609885,-0.06851813,0.004684896,-0.022922445,0.02579922,0.0384032,0.020915847,0.0340574,-0.015191607,-0.033458054,0.02718867,0.0001804995,-0.021570412,0.049022987,-0.047743574,0.013883512,0.042355314,0.0691035,0.00012729227,0.051294535,0.06723093,0.025070073,-0.047800746,0.02479164,0.002454973,0.03447243,-0.01080333,0.02363268,-0.031801403,0.06680479,0.08110876,0.00020609268,-0.052550513,-0.034510694,-0.068700075,-0.0076989722,-0.06235807,-0.0067554796,0.07497621,-0.012503215,-0.0076883812,0.014080493,0.0027635687,-0.009368628,0.033240076,0.021329662,0.027455967,-0.021129664,0.00036809527,0.018182043,-0.03290894,-0.061082445,-0.027306737,0.03544776,-0.015841892,-0.0047978135,-0.07303687,0.011830166,-0.010465835,-0.022414772,0.0712236,0.035875678,-0.05102795,0.022118216,-0.051353235,-0.0004176828,-0.024355363,0.0433519,0.06656158,0.087943815,0.031988166,0.03233495,-0.00025056125,0.03790688,0.031418864,0.009874859,0.059340023,-0.07393416,-0.04736598,-0.061283067,0.025566012,0.07406399,0.017922994,-0.023297556,0.020764608,-0.019020237,0.06541135,-0.00039107102,-0.110568784,-0.08032536,-0.04960424,-0.015231602,0.033822227,-0.023851471,-0.005841504,-0.03051566,0.06493912,-0.0010274344,-0.024192363,-0.038562946,-0.0071000163,-0.0036265193,-0.07592877,0.036699343,0.029050553,-0.053360447,-0.00090577017,0.0072779944,0.07877571,0.046286393,0.009229273,-0.13800168,1.4392208e-33,0.0648706,-0.08189905,-0.092898466,-0.08619441,-0.026858004,-0.01941106,-0.059583213,0.0017326815,0.04100012,-0.04937878,-0.016635893,-0.072512776,-0.005568638,-0.007708423,0.015552967,0.023794103,-0.06323175,-0.02442237,0.09157979,-0.1167242,0.011768401,0.031044615,-0.07578638,-0.02190448,0.07244871,0.010266476,-0.02583046,0.013731772,-6.8758105e-05,0.019005021,-0.013564531,-0.11499747,-0.035324648,0.07623497,-0.0032132838,0.1306576,-0.052098934,-0.06266742,-0.09455691,0.049038973,0.034711614,-0.039102715,0.071732014,0.015245547,0.03714542,-0.07376642,-0.12380979,0.06073853,0.06685019,0.0114273615,0.06910806,-0.05288698,0.07025839,-0.03876501,-0.06869415,0.04503509,-0.07895263,-0.034136076,-0.005187681,0.0031255865,0.006601934,0.03795101,-0.06915297,0.0929923,0.03750821,0.053138994,-0.102991745,-0.015611942,-0.008911236,0.11918845,-0.10742027,-0.049918603,0.092701785,-0.0014099296,0.018424291,-0.043775983,0.0076633366,0.04090122,0.031389866,0.028523775,-0.014878431,-0.05275783,-0.047214188,-0.016128445,-0.060036737,0.044456206,0.032648116,-0.059817564,0.027714616,0.032225583,0.02403612,-0.1116501,-0.026956031,0.043974288,-0.013236397,-2.500335e-33,0.0497644,-0.012971877,0.081723645,-0.054202504,-0.083289035,0.05028382,0.002745929,-0.0051922747,-0.0056017824,-0.04314723,-0.030450357,-0.0017901759,0.029201472,0.0054978402,-0.0730605,0.042654786,0.05554954,0.051604576,0.085629016,0.0022989966,-0.03910948,0.13999586,0.0748733,0.024088753,0.024428938,-0.008377932,-0.0033438487,0.03250909,-0.0041472395,0.042414866,-0.017301599,-0.00028292922,-0.036988337,-0.04143828,-0.059681773,-0.020782221,-0.041421458,-0.04929708,0.014295419,0.047034834,-0.049419727,-0.009782607,-0.040694658,0.13620004,0.026876006,0.036024824,-0.05041562,-0.0062341797,0.013028257,-0.044044312,0.018234609,0.031736013,-0.02651941,-0.020587312,0.031913828,0.054481298,0.060189933,-0.0106604975,-0.078282036,-0.014703413,0.027359786,-0.0038809278,-0.031918205,-0.021100698,0.085270956,0.07799974,-0.055687234,0.06772498,0.014489606,0.004845626,0.087655805,0.03266357,0.0364501,0.058062866,-0.061132364,-0.043633938,0.014826868,0.03123043,0.016578525,0.0005062178,0.06496777,0.04878785,-0.027228039,0.033264823,-0.03990117,-0.029723603,-0.02928015,0.082178034,-0.0017252087,-0.03956858,-0.03207341,0.05638468,0.028075911,0.057079844,0.11542181,-3.9781995e-08,0.01035653,-0.046605404,-0.052244198,-0.04458819,-0.020722717,0.04588248,-0.038480073,-0.09108964,0.021711698,-0.021941138,-0.047347926,0.08017778,-0.07513881,0.008103963,0.0658391,-0.014794921,-0.0937312,-0.013140194,-0.076705925,0.018990574,-0.055459775,0.021458743,-0.072720125,0.066765144,-0.03811346,-0.013994513,0.027670497,-0.010531089,-0.086612076,0.0808843,0.017326372,0.028428573,0.00826211,0.012439394,-0.0077423486,0.12558767,0.02736135,-0.100203715,-0.040963158,0.056158323,-0.012543087,-0.060935058,-0.0021507707,-0.010651922,-0.041705888,-0.03031869,-0.006920645,-0.008174953,0.01309736,0.048253916,0.08990399,-0.018596599,0.025031004,-0.013073263,-0.020503365,-0.027861753,0.008550489,-0.08713168,-0.018623501,0.008422082,0.0637751,0.042665474,0.22534882,0.015200289 +6.3.2.19,"Ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. An intermediate in the reaction contains one ubiquitin residue bound as a thioester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme.",384,1.0,-0.0670178,-0.0023804489,-0.07371423,0.026080962,0.024922887,0.084169745,0.021284875,0.04966828,0.028274711,-0.038264595,0.041671418,-0.0163794,0.011232841,0.024640411,-0.061370287,-0.035944913,-0.03879037,-0.029156636,-0.02063301,-0.04263111,0.038049433,0.07630708,-0.01113406,-0.007983196,0.0018549872,-0.035515163,0.056431826,0.0052563464,0.06473997,-0.08052199,-0.007233366,-0.030948782,-0.014484805,-0.03508083,0.0062390463,0.12074192,-0.025791056,-0.06817712,0.011896434,-0.049797084,0.062308844,-0.012684996,0.011933977,0.048909467,-0.016920261,0.002944549,-0.024446545,0.031430814,0.030286465,0.07717805,-0.023201529,-0.013357626,-0.021496307,0.01935777,0.03571799,0.0007074386,-0.09431747,0.013239993,0.008973125,-0.04004371,0.027261399,0.07986606,0.01600778,0.003452739,0.078814745,-0.06833813,0.046840504,-0.028090442,0.02322939,-0.010089446,-0.001664,-0.059038274,-0.06479596,0.030955883,-0.008202484,0.018926598,-0.08664093,0.04865221,-0.023965884,-0.053401466,0.02383406,-0.014136003,0.10487927,0.07052977,-0.0042569116,-0.024579674,-0.017187672,-0.01724079,0.03742681,-0.04820349,0.046193592,-0.031336926,-0.0006928818,-0.011023486,-0.049093243,-0.050348338,0.039132956,-0.0016386907,-0.043522447,0.07673255,0.021953372,0.053473625,-0.061903525,-0.027997991,0.005851049,0.015847035,-0.024450643,0.0360479,0.08737727,-0.0024711047,-0.061951187,0.012101598,0.035788424,-0.026564762,0.022757031,0.019371735,0.019418335,-0.025751535,0.030609665,-0.059236255,0.021495193,0.055210404,0.008705169,0.10427055,-0.0051010265,-0.0476763,-0.124458484,1.944273e-33,0.15869567,-0.022630917,0.08350872,0.045964435,-0.060007095,-0.02391967,-0.079457685,-0.027108949,-0.037686594,0.0067022596,-0.0052697356,-0.0025911345,0.059591703,0.033323225,0.003550522,-0.07205191,-0.038663186,-0.023203982,0.11388597,0.018559553,-0.055528454,-0.0084197195,-0.023012877,0.017740667,0.00032242012,0.014580932,-0.0017609416,0.07479985,0.0033022417,0.015904985,-0.07433789,-0.005377139,-0.09447524,0.003300872,0.006156351,-0.069076635,-0.034424447,-0.0724986,0.055105153,0.070685074,0.03465042,-0.032115895,-0.060890235,-0.099482834,0.14986485,-0.022838699,0.00686035,0.12542489,-0.037989393,0.0012756098,0.060503427,-0.0507164,0.053213898,-0.058284763,-0.11707574,0.0440328,0.02420145,0.015192765,-0.04288446,0.08583274,0.022542462,-0.016629575,-0.073972665,0.0146047985,-0.00018005489,0.06963038,-0.06666179,-0.034427725,0.032626737,0.014493993,-0.08497213,-0.0515794,0.115395956,0.010833484,-0.07280479,-0.030287998,-0.09423708,0.023605363,0.03413708,0.03478859,-0.07177978,0.0033309048,-0.089249395,-0.038245466,-0.04624368,-0.010157743,0.058211394,-0.1143271,-0.041339174,-0.008899014,0.00040713907,-0.03716919,-0.0034837893,0.014374782,0.058956638,-4.0791737e-33,0.09798875,-0.0876603,0.030739449,0.02524702,0.06415492,-0.04537598,0.05258264,-0.016911678,-0.017087039,-0.050333586,0.09377059,-0.05197265,0.013467285,-0.014797169,0.015056316,0.023108885,-0.022144606,0.041798323,0.043997582,-0.0012062466,0.017867353,-0.1255121,0.047540125,-0.07241502,0.003962777,0.027164593,-0.025960563,0.07451051,0.0016068405,0.02368646,-0.040721316,-0.036546264,-0.08242468,-0.041567612,-0.06076216,0.026218412,-0.030018402,-0.01708688,0.0401605,-0.1095381,0.05991577,-0.0089536635,-0.018567843,0.044497438,0.07823699,0.09642702,-0.040322725,-0.06760386,-0.08201847,-0.08455717,0.062354237,0.023963934,-0.033861842,0.033013888,-0.14068173,0.108224906,0.044997018,0.041097112,0.07591796,0.03307129,0.010520287,0.01559938,0.028964058,0.05125154,0.0078029186,0.0032374132,0.0048547694,0.025284303,0.08842525,0.0015354068,0.075395025,-0.07772445,0.11089408,0.021850202,0.05652904,0.015661297,-0.01596781,-0.06670301,-0.00050875644,-0.05441445,-0.053371422,-0.002702766,-0.032784406,-0.012785126,0.0031106044,0.02023322,0.025298135,0.11440229,0.026301805,0.05958635,-0.06557821,0.005343413,0.00048020095,0.02042722,0.04972297,-3.7752503e-08,0.059709862,-0.05871519,-0.027611297,-0.06279062,0.05734501,0.101766355,-0.041857682,-0.020414727,-0.049933456,0.03216735,-0.015826588,0.0034684942,-0.06943563,-0.030450916,0.015334886,0.097764805,-0.002796032,0.039306168,-0.019956544,-0.05539862,-0.058249734,0.062327154,-0.024944006,0.016154695,-0.021536363,-0.021518629,-0.011948422,0.05291165,-0.033523798,0.008060511,0.010862489,0.03575108,-0.031931326,-0.09904827,0.0011823077,0.031970885,-0.028378723,-0.055328596,0.03206509,-0.043210916,-0.0314406,0.047402706,-0.065799,0.024227547,0.06378786,0.015468176,0.03226117,0.06572394,-0.07037086,0.021435434,-0.023495262,-0.023507629,-0.059734885,-0.062704995,-0.057170104,0.004017146,-0.044405483,-0.092209354,0.034098,-0.09539022,-0.045026988,-0.0045886473,0.097463794,-0.035419397 +6.3.2.21,Specific for Ca2+-calmodulin from vertebrates. At least three ubiquitin molecules can be coupled to lysine residues in calmodulin.,384,1.0,-0.035033368,-0.09054397,-0.03463468,0.045475636,0.020569243,0.00931205,0.047342457,0.011879568,0.008955058,0.0108492365,0.07669412,-0.08600838,0.010504641,0.031641282,-0.020571485,-0.010157867,-0.05148836,-0.010268763,0.030599039,-0.02214176,0.056414165,0.10356395,-0.019379068,0.011155718,-0.045900535,-0.0543923,-0.06569305,0.075771034,0.11679742,-0.060720958,0.0092265345,-0.04430198,-0.041117936,-0.115491234,0.03806749,0.0057672556,-0.069908105,-0.029049024,-0.021776007,-0.051149677,0.10798671,0.002695516,0.020166263,0.075951144,-0.025052052,-0.01375163,-0.042857777,0.0033766702,0.05499036,0.053712726,-0.034720402,-0.000431685,0.01396993,0.0561774,-0.018571764,-0.012376421,-0.06833127,0.08377016,0.08157462,-0.041910287,-0.043374415,0.054979265,0.06921538,-0.08162444,0.07385388,-0.031354032,-0.056942012,-0.060795575,0.060002193,0.0021874616,-0.022809085,-0.07909029,0.056007974,0.03506893,0.0038612455,0.035144284,-0.03807051,0.013411774,-0.050682094,-0.016466971,0.056371383,-0.09643193,0.021608539,0.019071005,0.006039305,-0.005485351,-0.03559729,0.008385669,-0.028963227,-0.020182366,0.08924791,-0.024506833,0.07746885,-0.0027917807,-0.03932731,-0.0066839573,0.0054612644,0.057454325,-0.014448094,-0.023966746,0.035791665,-0.0045426376,-0.08078022,-0.05451239,0.008697951,0.012151707,0.011070549,-0.033839546,0.024230428,-0.020052187,-0.037806045,0.029797206,0.009160371,0.026622493,0.025081705,0.038762,-0.04119572,-0.03896865,0.0501359,-0.09945917,0.014844349,0.028327381,-0.00527604,0.00337534,0.014153833,-0.034182474,-0.13135706,1.7941497e-33,0.10522813,-0.024374576,0.03296205,0.052680288,-0.049804885,-0.04025795,-0.05078269,-0.029009705,0.02770492,-0.03393169,-0.008641279,-0.01918848,0.043517064,0.06368926,-0.065622374,-0.09268171,-0.026367255,-0.12508512,0.08549772,0.0060250117,-0.007860861,0.011929744,0.010573655,0.011888692,0.052810058,0.030776566,-0.04832903,0.0691858,0.009153052,0.013528582,-0.05105807,-0.07834277,-0.08983714,0.060151782,0.056253057,0.0077273548,0.016729098,-0.026309839,0.03623982,0.04613749,0.029089998,0.0029632861,-0.0082313195,-0.007204477,0.088043876,0.003393564,-0.09579005,0.094038986,-0.0087997215,0.01830003,0.059576992,-0.011460507,0.02951629,-0.09421621,-0.12338926,-0.0116000045,0.0074509336,-0.0490311,-0.08734915,0.055212688,-0.021241887,-0.053855613,-0.057820916,-0.018850122,0.04070703,0.09230058,-0.066918924,-0.06371562,-0.030602207,-0.03749078,-0.050241232,-0.040156484,0.10959719,-0.02296062,0.0036126324,-0.0077300486,-0.067012325,0.11659535,-0.022839248,-0.0048436117,-0.012496305,0.013529456,-0.095925465,0.07107769,-0.04112416,-0.030163623,0.07359251,0.024472179,-0.013360099,0.00022982767,-0.0009438899,-0.035623174,0.08822152,0.021799562,-0.053555198,-3.5359924e-33,0.06555645,-0.02984828,0.056288935,0.06074719,0.04764809,0.026418516,0.067882545,0.007543171,0.036459032,-0.028688055,0.10179602,0.018476881,0.0048886943,-0.02933995,0.05014293,0.094157465,-0.03725623,0.06270694,0.08005667,-0.06298567,-0.036248233,-0.06358158,0.0004533568,0.02479286,0.05471229,0.04660639,-0.009737714,-0.04166948,0.007619701,0.027307926,-0.106913306,0.014342664,-0.038181465,-0.028329227,-0.02744199,-0.029230809,-0.04913522,-0.06484327,-0.03208665,-0.02937529,0.0360755,0.021444753,-0.019645112,0.057885382,0.013717493,0.076370314,-0.0034337817,-0.045859393,-0.15081394,-0.0017612292,0.0849435,-0.004998637,-0.02979615,-0.024836121,-0.08038308,0.10167536,0.060266003,0.060317982,0.0446159,0.044170447,0.009534227,0.037847552,-0.076793455,-0.015755069,0.012841373,0.03230426,0.03940915,-0.030329786,0.024327248,-0.020413646,0.09694982,-0.024376938,0.07599317,0.010789853,-0.02181033,0.039037094,-0.006785347,-0.053070918,0.0593757,-0.028076425,-0.016640924,0.024625484,0.015507208,-0.014938778,0.016641824,0.03611409,-0.034888364,0.05274931,0.05170745,0.0045705494,-0.04406841,-0.065372646,0.018505756,0.05524744,0.11628357,-2.4357938e-08,0.067752875,-0.039091364,-0.090953626,-0.04172382,-0.025533436,0.026331456,-0.03724758,0.035678618,-0.019613156,0.055608895,0.033772238,-0.035715234,0.006265476,0.0028699068,0.005848492,0.09513405,0.027091019,0.04757548,-0.018540576,-0.0035009696,-0.05032463,0.03509249,-0.06436159,0.024787903,-0.011354055,-0.021389384,-0.0041193017,0.06031751,-0.040725876,-0.017055336,0.015611703,-0.021865621,-0.073424,-0.1529085,-0.011379188,0.007938884,-0.039051183,-0.15263033,0.04818876,0.057301376,-0.043154202,0.051396128,-0.06266895,0.0050314586,0.025401577,-0.04218621,0.022841828,0.021108171,-0.012421687,0.012612582,-0.00580804,-0.036481343,-0.005901879,-0.12840149,-0.10620338,-0.015590563,-0.043072812,0.008727887,0.034198154,-0.08969177,0.015792761,0.058621705,0.09937665,-0.04314564 +6.3.2.23,Not identical with EC 6.3.2.3 glutathione synthase.,384,1.0,-0.06853441,-0.103034064,-0.05961411,0.00017876254,0.036895484,-0.016747301,-0.0758549,0.06985695,0.026265651,-0.09408502,0.072640024,-0.048283767,-0.026075855,-0.049871333,-0.025633352,-0.04018215,-0.032827232,-0.059237503,-0.06930246,-0.04437898,-0.009120896,0.02547029,0.018660886,0.03378948,0.061706357,0.014654387,0.047791213,0.01964211,0.009985238,-0.0756458,-0.03998452,-0.03404546,-0.0023761303,-0.012699792,0.029978026,0.029402021,-0.064333625,-0.07116062,-0.02434837,0.0054647955,0.06381093,0.015872115,0.027422806,-0.066128366,0.0423664,-0.019676251,-0.06661041,0.011807232,-0.009623304,-0.014127793,0.016573006,-0.10683833,-0.020768723,0.0024054402,0.033569917,-0.008086968,-0.08002272,-0.021764478,-0.04029574,0.08847209,-0.01910776,0.06488384,0.028299171,-0.075604156,0.08678451,-0.027901348,0.07175518,-0.10836509,-0.025236547,-0.015972532,-0.06219806,-0.045847885,0.00802223,0.050535593,-0.010099541,0.0679769,-0.074610986,-0.03776247,0.02054956,-0.016965687,0.029978005,-0.06440007,-0.06736269,0.047446027,-0.0077342903,-0.021466224,0.0151900295,0.017472224,-0.0051313825,-0.0011009035,0.065600276,-0.024468653,-0.027585737,-0.012713209,-0.06478057,0.065993644,-0.079721116,0.13843614,0.031094905,-0.027491547,0.0022934172,0.05599654,-0.06446154,-0.006716057,0.019098729,-0.0065680975,0.04052118,0.10304664,-0.024531323,-0.019181613,0.009694255,-0.04766745,0.015118906,0.04636775,-0.038442682,0.11617391,0.038311813,0.0007658866,-0.02953764,0.08773742,0.06450793,0.01673889,0.056095924,0.0384407,-0.018044073,0.023292433,-0.032566078,6.72068e-34,0.028346337,0.06216242,0.10126099,-0.006113571,0.021997461,0.0621622,-0.13133651,0.008378028,-0.053692773,-0.0629056,-0.085890085,0.025999941,0.0028883442,-0.0013160928,-0.022348449,-0.039052546,-0.027845208,0.045617525,-0.02047014,-0.044735286,0.107428685,-0.0084849885,-0.037849035,-0.0031698637,0.0052626194,0.06828776,-0.010263311,0.020608952,0.015970264,-0.011452209,-0.07728975,-0.024985448,0.024523145,0.0017312197,-0.016284158,-0.04255564,-0.020788934,-0.07524535,0.004298236,0.018363737,0.068184555,0.07200512,-0.0072411257,-0.07107057,0.054718755,-0.007582111,-0.045673963,0.029033411,0.06387658,0.05050078,-0.019322943,-0.016777739,0.11308004,-0.0030339342,0.054053485,-0.03887521,-0.011942647,0.012169432,0.07531578,0.10728381,0.0036999641,0.17870143,-0.055743616,-0.013982503,-0.03577124,0.0647829,-0.07489323,0.006921246,-0.052280772,0.09066181,-0.009137586,-0.07163939,0.0013585413,0.08820178,0.042005457,-0.10219287,-0.12805557,0.028030679,-0.058506094,-0.054392494,-0.0367877,0.06724449,-0.0038366676,0.04495914,-0.11246916,0.0030862088,-0.015576499,0.009184222,0.022457069,0.061613157,0.11309332,0.015096166,-0.0360089,0.016304508,-0.04131856,-8.88662e-34,0.034708478,-0.03218881,0.03436808,-0.042567257,0.039873376,0.034794793,0.033294965,0.024486085,0.111015834,-0.0092135025,0.12300951,0.02360121,-0.019123575,-0.06178106,0.050254244,-0.028096052,-0.038352586,0.02496004,0.044742882,0.019997457,0.06298137,-0.012695298,-0.018579189,0.058365498,0.052738458,0.021046301,0.02699222,0.08297501,0.06514437,0.0141301425,-0.06080951,0.010149821,-0.064053245,-0.03730479,-0.017254183,-0.0054023913,0.008215086,0.013535733,0.003659469,-0.057846054,-0.0193727,0.059635065,-0.0042545414,0.07474728,0.084549814,0.07250705,0.045165617,0.015753726,-0.0155707495,-0.036991827,0.011047274,-0.07635201,-0.036811586,0.0060316455,0.017750628,-0.051988084,0.038545266,-0.037430264,-0.07707756,0.013213461,-0.014439918,-0.053992853,-0.019535987,-0.07557382,-0.022357628,0.059686035,0.05867425,0.0980283,0.059041504,0.024790356,0.07085861,-0.07783045,0.005449403,-0.03073347,-0.044580523,-0.023969816,-0.03867771,0.05348883,0.044782553,-0.08725626,0.0030193564,0.03311672,0.00043112683,0.00014266354,0.0023984099,0.020958118,0.016359879,0.10584447,-0.021560078,0.089910634,-0.08733796,0.013946363,-0.0800123,0.047571305,-0.00223835,-2.2491193e-08,0.06409331,-0.066766284,0.050099555,0.0006276007,0.052252583,0.0024764147,-0.0019333203,0.04899593,0.043851677,0.032024626,-0.016173895,0.0379431,0.04578283,-0.047991745,-0.02246445,0.0012636868,-0.041662727,0.0820801,0.0015349803,0.047623973,-0.052043535,0.032652374,-0.053770952,-0.09152716,-0.033162273,-0.025436793,-0.015114976,0.04277822,-0.025617871,-0.03368119,0.060253717,-0.03918644,0.008289687,0.00069386343,-0.06498065,-0.03436714,-0.041450247,0.0022945893,-0.038779996,-0.005286599,-0.01438741,-0.021144463,-0.05130227,0.0029181666,0.027933272,-0.0045079114,0.03312637,-0.09299796,0.005254373,0.008392598,0.031090867,-0.036691695,0.026367195,-0.048837494,-0.042891026,-0.014702111,-0.05864018,-0.09191767,-0.003165797,-0.045140974,0.048102196,-0.08409849,0.15156533,0.118642725 +6.3.2.25,"L-Tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyromega-alpha-tubulin). The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine. L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.",384,1.0,0.0062523335,-0.07692554,-0.04642432,-0.102465235,0.07842978,0.044293687,0.0340538,0.089519076,0.020773562,0.046508532,0.06522657,0.004011489,-0.06769301,0.09205276,-0.02738652,-0.0024723513,-0.078995585,0.033656828,-0.01834763,-0.02804458,-0.0053184982,-0.007833254,-0.021652292,0.044606943,0.038479242,-0.03411236,-0.019977361,-0.04690574,0.0066316975,-0.03081857,-0.1012254,-0.062563665,-0.03630816,-0.05778387,-0.0029568346,0.0007702022,-0.11449792,-0.105383106,0.026620563,0.033583015,0.08330644,-0.045885134,-0.01809287,0.018228443,-0.02247701,-0.0006579988,-0.018687291,0.07767829,0.040072523,0.05910051,-0.0050685373,-0.030260006,0.022529365,-0.01132902,-0.118471466,0.06349327,-0.020749515,0.09191102,0.022339042,0.10076264,-0.027284773,0.09058796,0.027865162,-0.000696102,0.052821644,-0.07270907,-0.04120384,-0.004830462,0.042737383,-0.04274843,0.0061460966,-0.10040002,0.018092655,0.001037806,0.00053408695,0.032548364,0.0013063824,0.06592364,-0.033620354,-0.00026221233,0.051053595,-0.0054623648,0.020639952,0.066117115,0.02254535,-0.0049623535,-0.055579986,0.04085197,0.071467675,-0.0145934345,0.040829156,-0.013719101,-0.03683176,-0.018473618,-0.0853405,-0.04797195,0.00254719,0.05528624,-0.035685576,0.04974745,-0.009950881,0.074020796,-0.08355363,0.0138178775,-0.04700269,0.009183085,0.012014506,0.008751162,-0.063141584,-0.07399782,0.038689002,-0.021876331,0.09270152,0.032224018,-0.024347445,-0.011414606,0.02367431,-0.036644224,0.056969665,-0.04534747,0.043560684,-0.047851957,0.07569581,0.04969369,-0.04310608,0.07742841,-0.052263204,1.0928466e-33,0.069937445,0.0038873025,0.038493957,0.022129135,-0.024270093,-0.0038542636,-0.0786053,-0.019818163,0.0031104959,-0.032785032,-0.122018,-0.050900195,0.029647449,0.020262092,-0.08275023,-0.025576921,0.0005851783,0.0031326322,0.03405994,0.06404059,0.061850328,0.101999715,0.0043364847,-0.0021489332,0.07431793,-0.00670775,-0.026735194,0.029477244,0.020433689,0.0042001833,-0.027879227,-0.08991841,-0.026620662,0.02174579,0.039153375,-0.035242625,-0.0471915,-0.052567344,0.05437977,-0.017286858,-0.009665742,0.03133167,0.0077148257,-0.004443079,-6.8507343e-06,-0.00061065436,0.0152329,0.0068056607,-0.052337952,-0.061612878,0.103920825,-0.0701466,-0.03963658,-0.0264191,-0.012930656,-0.0072578946,-0.095686086,0.0034446977,0.00828501,0.114951625,0.04288064,0.0014938044,-0.014731358,0.016429415,0.06294347,0.031681597,-0.04157155,-0.026816847,0.018190475,-0.04449922,-0.10705097,-0.07037933,0.1372518,0.013288594,0.016314112,-0.016493153,-0.042059164,-0.014420848,-0.042150874,-0.035222486,-0.002624442,-0.052110482,-0.0026849785,0.03266372,-0.022812523,0.019123115,0.039475672,-0.08559757,0.030574555,-0.00038715306,0.0017538868,-0.0128198,-0.060402997,0.057411432,0.050407022,-1.7673082e-33,0.012986972,-0.103331245,0.06794631,-0.08692641,-0.061804805,0.0338349,0.06362973,-0.09260552,0.078359775,0.046347488,0.05682791,0.005578293,-0.06809318,-0.0914287,-0.026623707,-0.01988224,-0.013544064,0.0143530695,-0.043138698,-0.061673682,-0.018082118,0.04551971,0.05232207,0.017989738,0.07767614,-0.008589752,-0.0071781636,0.07278829,0.05288454,0.049972694,-0.052109677,0.028552003,0.04733711,-0.0095528,0.0022898267,0.07301495,-0.020195037,-0.022215866,0.044311427,-0.0073649017,0.026896335,-0.02365311,0.0491926,-0.02928285,0.048097644,0.07511699,-0.07004682,-0.04128333,-0.027399486,0.004122114,0.03307212,-0.06867962,0.035327163,-0.053875394,-0.01815525,-0.011137046,0.030208308,0.022590013,-0.020738324,0.021025946,0.04543515,-0.07376628,-0.021602213,0.071848236,0.041468337,-0.033674885,-0.00019807811,0.047455188,0.048579104,0.014378725,0.038389526,0.032076918,0.097008124,0.118082024,0.002073308,-0.057686325,-0.056652267,-0.06647796,0.059151515,-0.103666596,-0.10536945,0.045881983,-0.025164263,-0.012374821,0.07472871,0.011822302,0.0011972336,0.11088661,0.008557173,0.038741093,0.030146295,-0.04868971,-0.08400622,0.036065638,0.11021562,-3.8926867e-08,0.12330432,-0.009189132,-0.038636185,0.0075389445,-0.083458826,0.020252798,-0.02748323,0.0028370626,0.012057954,-0.022959465,0.026042547,0.123411946,-0.0038163243,-0.02869898,-0.002888473,0.06358644,-0.022086415,0.0030857837,-0.027476702,-0.0013257132,0.016109426,0.0028351727,-0.07138367,-0.011498081,0.0003007067,-0.06358638,-0.020444939,0.15617998,0.0069959485,-0.059384257,0.030197091,-0.058001783,-0.012397605,-0.044182118,0.038419355,0.09147195,-0.09584647,-0.047993887,0.0026898165,0.024895512,-0.071484625,0.0046570958,-0.015989752,0.0073330635,-0.030860208,0.03776226,0.018984506,0.061901946,-0.0025191163,0.020917308,0.04421686,0.01110344,0.010337177,-0.071462564,-0.10600833,-0.015798753,-0.053371634,0.011678448,0.002156024,-0.11318173,-0.024983503,-0.016241498,0.1530856,-0.06171375 +6.3.2.26,"Requires Mg2+. The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction. Forms part of the penicillin biosynthesis pathway (for pathway, click here).",384,0.99999994,-0.03209498,-0.05912609,0.0011177398,-0.016839989,0.04055893,-0.057137005,-0.038592085,0.03542819,0.02912387,0.021711566,0.015538359,-0.02778817,0.040218588,0.099766426,0.008066602,0.0048597828,-0.09119937,0.05346337,-0.011901721,-0.02679659,0.10181145,0.046299458,0.021100843,-0.030472571,0.044608176,-8.006624e-05,0.10411844,-0.009449369,0.06831484,0.0024996367,0.032570288,-0.008537838,0.017148875,-0.10031833,0.0681264,0.06811876,-0.07928679,-0.025067288,0.09042799,0.0049341875,0.04389562,-0.00020037357,0.048469745,-0.015057577,0.024307035,-0.036855742,0.09524302,0.018260388,0.048289943,0.054151293,-0.02055848,-0.028615912,-0.044425257,0.029207513,0.042888805,-0.011405813,-0.10916673,-0.050240055,-0.0055437866,-0.05148797,0.0013736787,0.009912093,-0.025639806,-0.011272913,-0.035075873,-0.0010754785,0.0054391217,-0.077990934,0.039117865,-0.029570134,0.014355226,-0.047988996,-0.008871464,0.03157661,-0.014021919,-0.028713925,0.037568424,-0.015969848,0.015663387,-0.0056687905,0.04264547,-0.020843511,0.010417707,0.110254474,0.079957366,-0.040550783,0.07866556,0.039040204,0.04860792,0.062023774,0.049233925,0.06286996,-0.0360102,-0.036295816,-0.018541863,-0.029830309,-0.0666639,0.02140148,-0.026640264,0.0043251268,-0.029011732,0.0837614,-0.031411394,0.026914522,-0.02755945,0.0023738903,0.0048577795,0.042536397,-0.055984464,-0.008784231,0.06770693,-0.012166995,0.032146536,0.00035849336,0.00069317815,0.043266945,-0.031237194,-0.10938422,-0.025955113,0.058843642,-0.0075199073,0.017234046,-0.034525484,0.03761616,-0.062291298,0.042778376,-0.07801178,1.0449815e-33,-0.04032038,0.0942778,0.016989706,-0.041325428,0.006721427,0.02675045,-0.030341664,-0.056740984,-0.0387867,-0.03551594,-0.08574617,-0.10674811,-0.0006971512,0.058120195,-0.03742444,-0.033829413,0.05864591,0.014935679,0.07092315,0.06663261,-0.021148216,0.060873795,-0.04321604,0.0122044515,0.04002015,0.083879314,0.044664647,-0.016427059,0.09246813,-0.016672015,-0.008249165,-0.06690654,-0.010122589,-0.02313659,0.03606533,-0.03007331,-0.006022151,-0.051079594,0.020234408,0.056582857,-0.082033455,0.012599926,-0.07802297,0.016084645,0.06612195,0.004423535,-0.042499427,0.08382986,0.036910504,0.06363931,0.12083999,-0.0084065525,0.046141896,-0.013900951,-0.06634175,-0.012587584,-0.0723625,-0.0053295675,0.054328613,0.0030493739,0.024897933,-0.0035084772,-0.0057820724,0.0782918,0.07305173,0.026958147,-0.06380816,-0.080460355,-0.027728416,0.03846836,-0.08781902,-0.035095453,0.019784471,0.036165338,0.035655696,-0.018799232,-0.03458826,-0.043409336,0.0747981,-0.019536328,-0.043368965,-0.011731784,0.03383639,-0.018910354,-0.04289524,-0.04088279,-0.009225692,-0.032399435,-0.024990212,0.0080273505,0.035286278,-0.06860311,-0.0957315,0.07973502,0.021371149,-2.4019609e-33,0.0780185,-0.020904278,0.04326014,-0.066940226,-0.11858679,0.07534968,0.007781854,-0.12685204,0.14488691,0.039028466,0.050374668,-0.051590208,-0.038613547,-0.025775094,-0.0510375,-0.040665176,-0.009439761,0.1045744,-0.021887403,-0.011655072,-0.0022709602,0.025521893,0.026191235,0.016615314,0.05494193,0.034019295,0.0119922375,0.05424033,-0.002258334,0.08013385,-0.038538337,0.027511396,-0.04864916,0.0024135795,-0.07692065,0.14106683,0.038324542,-0.057108685,0.01675952,0.031250656,0.004312165,-0.0063586505,0.08415822,0.107269734,-0.021607418,-0.038917243,-0.024715675,0.08002985,-0.005433936,-0.13606894,0.016125541,-0.039129104,-0.009729773,-0.052127525,0.006946499,-0.0052768514,-0.0015306721,-0.042716738,0.03938928,-0.05519671,0.0059244027,-0.06934776,0.03968987,-0.017795466,0.00348942,-0.0035702365,-0.011474372,0.06279769,0.049201757,0.03130868,0.018050868,0.09602506,0.06868269,0.03486009,0.020195883,0.10362469,-0.042487208,-0.056877676,0.09851324,-0.094002806,-0.008808119,0.010874576,-0.017670393,-0.03219522,-0.06557276,-0.080639735,0.025114255,0.07858182,0.019082244,0.0070663863,-0.049904913,-0.034185685,-0.0076806615,0.066499405,-0.013654408,-4.027633e-08,-0.008314348,-0.016722284,0.015728788,-0.039038215,0.015585606,0.09498585,-0.004564371,-0.09173751,0.06988752,-0.027422998,-0.039071612,-0.0034903558,-0.020249061,-0.018422525,-0.008815283,0.05600098,-0.07810315,0.004233402,-0.023993801,-0.05208124,-0.051557466,-0.04189119,-0.13348272,0.012723209,0.060264945,-0.120392546,-0.007306279,0.07217751,-0.09441379,0.015945558,0.043824438,-0.06581835,-0.07062418,-0.08127386,-0.039883185,0.025355281,-0.06572453,-0.04043847,0.032669686,-0.050042305,-0.020750847,0.00048500218,-0.012960248,-0.03434307,-0.04404412,0.026879016,-0.043911826,-0.029455703,-0.08226554,0.0008934235,0.07443736,-0.055127308,-0.032684926,-0.04339346,-0.068381876,0.0101751825,0.014896243,-0.050841182,-0.053508252,-0.121176995,-0.034752306,0.06588437,0.106315814,0.014656695 +6.3.2.27,"Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation [5]. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxylysine and one molecule of citric acid. This is the last of the three enzymes involved in its synthesis, the others being EC 1.14.13.59, L-lysine 6-monooxygenase (NADPH) and EC 2.3.1.102, N6-hydroxylysine O-acetyltransferase [3].",384,0.99999994,-0.04499052,-0.016108591,-0.10718406,0.04896685,0.095170274,-0.0049898988,0.029649638,0.0061909864,0.023739146,-0.043836944,-0.05672528,-0.05497452,-0.024700733,-0.072063476,-0.028330091,0.053446535,0.02660286,-0.005082719,-0.06760102,0.003746902,0.019375244,0.027291393,0.017497577,-0.031374257,-0.02173991,0.020227216,0.029591609,0.002463929,-0.041265592,-0.022481728,0.091149084,0.014940219,-0.021396173,-0.0760046,0.04460123,0.028070308,0.0066776415,-0.04470571,0.03723571,-0.018604608,-0.021819972,0.01699217,-0.022030132,-0.020999415,-0.06498153,-0.059376966,0.04964324,0.0058607953,0.09024421,0.057750773,-0.07832387,-0.010240885,-0.038106594,0.052029584,0.042221017,-0.0005822009,-0.10809312,-0.058780316,-0.00097650767,-0.033308364,-0.014358593,-0.033332698,0.003075036,0.007327471,0.033136375,-0.053143557,0.010281822,-0.095065214,0.031474277,-0.07301409,-0.09232127,-0.018086294,-0.05058872,0.028257236,-0.024991322,0.08842794,0.003074483,-0.049143195,0.08571838,-0.028037561,0.0037983677,-0.00923511,0.03092057,0.10702944,0.03273582,-0.033956334,0.048758626,0.055059988,-0.017523441,0.10241683,0.019814454,0.034747355,0.08249519,-0.04517012,-0.018413473,-0.050783854,-0.0037447282,0.041291784,0.004243755,-0.004525811,-0.057513263,0.08329602,0.066914745,-0.06629236,-0.100227974,-0.016755221,0.018607344,0.08616271,0.12683426,-0.03483851,-0.007528149,-0.036195643,0.021253254,-0.010774475,0.0037797631,0.094015755,0.029546706,-0.09716487,-0.054201372,0.0037529492,0.06837808,-0.03346922,0.046296358,0.0059924577,-0.08041197,0.001475157,-0.116062865,2.8586588e-33,0.048477806,0.043189663,0.06287976,0.009457827,-0.023714857,0.07519079,-0.12696151,-0.045176968,0.014804609,-0.0017785156,-0.11798621,-0.056070775,0.011342027,0.03067051,0.036749873,-0.099320166,-0.039899126,-0.043317415,0.06643587,-0.009667658,-0.016381847,0.11040373,-0.060424153,-0.015035207,0.0036961182,0.11015804,-0.02930526,-0.0042569735,0.010651675,0.029829437,0.06914447,-0.06597788,-0.10408619,-0.010091092,0.0077293334,0.00011284825,0.009852983,-0.037575748,0.00958784,-0.012155991,-0.02268739,-0.01996006,-0.014502568,-0.06341058,0.053049278,-0.071196675,-0.091897845,0.06940141,0.029145053,0.03593882,-0.0028981555,-0.011239856,0.080218926,-0.030243339,-0.044397783,0.01824319,-0.046205197,0.030824782,0.07612717,0.038589545,0.02607518,0.032509223,-0.0050156927,0.09354165,0.004507823,0.013981671,-0.039031312,-0.016860772,0.016084997,0.050107885,-0.015331404,0.017540192,0.1170669,0.0011836233,0.035325427,-0.062356222,-0.036183227,0.0029035655,0.05706714,0.04916321,0.0538114,0.052578725,-0.02194211,-0.053915244,-0.07661862,-0.007055414,-0.08449295,-0.0012110469,-0.047123782,0.050552342,-0.024639709,-0.038584877,-0.06798649,0.0037590098,-0.017609868,-5.56263e-33,0.061527982,-0.07219186,0.03704336,-0.059730485,-0.049267504,0.10899642,0.07563205,-0.03987721,-0.040786725,-0.029781597,0.11749856,-0.026515357,0.0009274382,-0.06363145,0.06488546,0.02258405,-0.06075793,-0.00095571415,-0.006124028,-0.016726619,0.025416352,0.017598733,0.013300148,0.018380553,0.016382623,0.012976717,0.019723598,0.0004466966,0.09071387,0.096539274,-0.03770032,0.0713265,-0.02635275,-0.0470996,-0.038069017,-0.0152631905,0.008702817,-0.022644004,0.0016683134,-0.038003176,0.011217062,-0.02139661,0.04431283,0.071759075,0.058232177,0.04743538,-0.05324044,-0.014950422,0.03114806,-0.030211588,-0.01631026,-0.0024302413,-0.05950278,0.033519115,0.1117919,0.040877797,0.0707269,-0.026895864,-0.00074422883,-0.02420942,-0.07235465,-0.019138725,0.09473525,-0.0075817816,0.016046826,0.11770878,0.003281878,0.06451705,0.04361857,-0.032243755,0.058522694,-0.04316686,0.075078964,-0.02876235,-0.0054340702,0.04448788,0.010436842,-0.008378665,-0.04091447,-0.008778975,-0.013195837,0.007317195,-0.025981145,-0.083396606,-0.0120731015,-0.12902308,-0.00017052746,0.034821358,0.010291276,-4.8879894e-05,-0.039158527,-0.033971082,-0.040990688,0.019141592,0.025711277,-5.0934478e-08,-0.053230505,-0.09863483,0.11438284,-0.057833064,0.0060391333,0.11605678,0.001861231,-0.05436055,-0.017497621,-0.06812057,0.06758489,0.022666613,0.030159071,0.034243997,0.015011349,0.022669304,-0.053420626,0.02420607,0.02826673,-0.017683921,-0.08728351,-0.04507703,0.0027804566,0.04222134,-0.028802285,-0.07027188,-0.08335795,-0.03938479,0.03864979,-0.031897858,-0.06647018,0.028349647,0.00848109,-0.07955025,-0.13392444,0.003913303,-0.054547,-0.023534061,-0.091165006,-0.033588987,-0.018707471,0.011084238,-0.05992646,-0.008671255,0.05427241,0.004330659,0.016858177,0.06901597,-0.09136796,-0.007850003,0.021492492,0.020949561,0.07211967,-0.01312911,-0.09661417,0.12175959,-0.02372802,-0.06358822,0.03131326,-0.045683693,0.0078538535,0.010169384,0.046046283,0.008282075 +6.3.3.3,CTP has half the activity of ATP.,384,1.0,-0.033245113,0.022897927,0.045431346,-0.03549876,-0.048911784,-0.04908585,-0.002465184,0.0625282,0.01914816,0.029362932,0.019463677,-0.013789895,-0.05298678,0.0675635,-0.0069631715,-0.044789333,0.004284262,-0.00052794,0.078940175,-0.022415493,-0.010667161,0.026288355,0.0030765696,-0.008576638,0.012580863,0.074433975,0.0065185553,0.0011670921,-0.03464175,-0.032055102,-0.1029284,0.013609601,-0.047649115,-0.035579395,0.0071380865,0.101716645,-0.11635666,0.015116104,0.051086552,-0.016252188,0.08820469,0.007073865,-0.016508458,0.10462233,0.006068815,-0.0033422448,-0.018755738,0.0474776,0.0069283796,-0.028757107,0.012338765,0.010266495,0.020164175,0.043409646,-0.03499515,0.018797804,-0.061706904,0.018765181,-0.025792116,-0.019299679,-0.05623805,0.01730494,-0.031140149,0.06729304,0.104537725,-0.03723453,0.0069527645,-0.0021943115,0.008645628,0.01761354,-0.0547348,0.024620548,0.007691553,0.032387882,-0.033811715,-0.006171261,-0.0129714515,-0.0709339,0.03932553,0.023007175,0.019159198,0.04447389,0.036747027,-0.012008138,0.08897482,-0.056800183,0.026145369,0.029011592,-0.02299958,0.040724315,-0.018405983,0.032686904,0.0003687681,0.01927643,-0.054820366,0.0059170513,-0.021375796,-0.0066099344,-0.10830673,-0.029410504,0.016828118,0.11216192,0.03384962,-0.02969712,-0.0009790555,0.004404975,-0.02040516,-0.02099988,0.004154342,0.040611766,0.017072828,0.015118483,0.036793593,-0.0304442,0.11879739,0.06830646,-0.02418832,-0.017681932,0.009348443,0.011079508,-0.09475271,-0.14186837,-0.05166697,0.03398568,-0.055145808,-0.004274163,0.032961495,-3.9837313e-33,-0.014822684,-0.023817727,0.04671625,0.010842996,0.050523657,-0.00035120113,-0.044171516,-0.024471529,-0.039482232,-0.08452214,-0.044968523,-0.04899661,0.013551707,0.023977064,-0.043279544,-0.022221206,-0.06167725,0.11135505,0.0973623,-0.09452027,-0.05097272,0.05530273,-0.0063783107,0.0027578522,0.042589694,0.0143454075,-0.0981994,0.004329595,-0.014370452,0.0047604237,-0.036943555,-0.0047053187,-0.07393737,0.08354349,-0.016109172,0.019860681,-0.029555848,-0.02776629,0.042936116,0.055425964,-0.08714838,0.023521792,0.035273857,-0.06216184,-0.038506042,-0.09579128,-0.063334204,-0.00040603796,-0.043994024,0.028960446,0.1270094,-0.04871431,0.03912862,-0.05895136,-0.021413824,-0.03515877,0.029743768,0.03706078,0.0212675,0.13338813,0.074186385,0.05132805,-0.03556102,0.027014064,-0.010744109,0.08866147,-0.10896096,-0.10642891,0.056525134,0.090960205,-0.041623615,-0.008650291,0.09091014,-0.052493535,0.08468638,-0.0012893875,0.069775574,0.045928456,-0.06353682,0.1113694,-0.016073115,-0.15725805,0.026057195,-0.034775905,-0.04380893,-0.012690812,0.053074185,-0.026826791,0.03911423,0.020242866,0.107230894,0.013694611,-0.03549011,0.02973366,0.035359062,2.1090358e-33,0.018298874,-0.056082442,0.0150058195,-0.04387691,-0.053000174,0.0122684445,-0.0039900346,-0.07514024,-0.0082790945,-0.0066766175,0.11398708,-0.0020231523,-0.100884125,0.004441531,-0.0028418996,0.0018763037,0.055333614,0.08075822,-0.022792032,0.04485015,-0.00026367637,0.0762932,0.021429459,0.09376249,0.036894888,0.01802497,-0.025262494,-0.011662601,0.06221244,0.005148482,-0.010097763,0.0044737514,-0.09193608,-0.020172438,-0.020733207,0.012722257,-0.043746565,0.06502939,0.02971228,0.017124653,0.11550735,0.021601602,-0.008418543,0.040576503,0.005599451,-0.020195367,0.092854805,-0.032890283,-0.075767234,-0.01322374,0.060649935,0.049458355,-0.034984175,0.05758652,0.048625126,0.07281594,-0.011460243,-0.027825974,0.007357631,-0.07662298,-0.0783561,0.0032192797,-0.055035148,-0.04353731,0.076602586,0.017344838,-0.04383854,0.03915059,-0.03292407,0.04856276,0.021192642,0.11885351,0.002472834,-0.06691963,0.014034271,0.070443094,0.0051630787,0.009776804,0.013598746,-0.05500405,-0.06862778,0.05441253,-0.024977528,-0.1359693,-0.05962377,-0.03595348,-0.04787483,0.0021216006,0.030467598,0.024601692,0.022808114,-0.03868693,-0.0128665045,0.0050640386,0.029721243,-1.4625925e-08,0.029737273,0.025056781,0.045708504,-0.036003314,0.024468157,0.06554597,0.054319136,0.055896476,0.090569906,0.007136959,0.0106418105,0.082971245,0.08179556,-0.034751542,0.053688098,0.038482636,-0.06672922,-0.01086259,-0.028029742,-0.047297455,-0.06676748,-0.03245558,-0.05492171,0.09054986,-0.0051953616,0.021485833,-0.044004645,0.036109243,0.040357772,-0.11760153,0.003931754,-0.05592546,-0.03359693,0.008632269,0.02340457,-0.0133205,0.052204877,-0.051181637,-0.106856875,0.028178023,-0.10422279,-0.10702911,-0.025393533,0.039321072,-0.017683642,0.058338765,0.037862506,0.011224918,-0.016096212,-0.09311009,-0.0019622098,0.028087053,0.0042381,-0.07294346,-0.06088826,0.014082877,-0.003060374,-0.02751584,-0.1167709,-0.046339698,-0.0059867105,0.030570751,0.08289861,-0.0073949457 +6.3.3.4,"Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It has been proposed [3] that L-N2-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the beta-lactam ring is then formed by the intramolecular attack of the beta-nitrogen on the activated carboxy group.",384,1.0,-0.009688189,-0.070548594,-0.10248387,-0.017457865,-0.022297213,0.091190346,-0.02335349,0.03398034,0.048778947,-0.049314942,0.0022968343,-0.0138085345,0.046410494,-0.022500528,-0.08069428,0.0027983375,-0.042781,0.0048972275,0.11156018,-0.020335427,0.025894908,0.13369341,-0.024742853,-0.065538384,0.088618726,0.04665484,0.009950415,-0.014105716,-0.015609007,-0.07335119,0.04424301,-0.038025342,0.03256785,-0.038904708,0.01329652,0.009457536,-0.02608837,-0.05475468,0.14270513,0.03995546,-0.0019940683,0.04513291,-0.01701881,0.0023639614,-0.015935946,0.003986569,0.007551156,0.068955876,0.021986844,-0.077124916,-0.0059251986,-0.0766614,-0.018231425,0.006977259,0.0052768444,0.06725651,-0.10902783,0.0053511485,0.044702634,0.036690053,0.048161637,0.055660855,0.059703685,-0.015233402,-0.017201308,-0.07541205,0.03523211,-0.05755915,0.085727945,-0.0068036793,-0.031340845,-0.017066402,-0.022843376,-0.028043283,0.0024527498,0.008671496,0.011342157,-0.0260062,-0.0072426344,-0.036911104,0.02880308,-0.032774888,0.021495271,0.041774824,-0.0069881235,-0.08732151,0.017953625,0.049350444,0.04778493,0.052947212,0.068280675,-0.0011692,0.03221346,0.019469693,-0.06472033,-0.010022786,-0.040007815,-0.022821644,-0.022198057,-0.0071071847,-0.030865531,0.023490608,0.023637347,-0.048596032,0.026027177,0.0067239976,0.037473027,0.019862492,-0.001364351,-0.030452516,0.02562032,0.012178189,-0.014155247,-0.014810457,-0.027285593,0.04798081,0.03707164,-0.041231837,-0.039320003,-0.01997292,-0.016533853,0.0018999398,-0.053270694,0.011453636,-0.05001537,0.10750276,-0.08980408,2.709508e-33,0.005740911,0.005671904,0.05827481,-0.027490698,0.09316274,-0.06723053,-0.10500367,-0.04001836,0.08298469,-0.0034205695,-0.05940331,-0.107183985,0.037758745,0.032810137,0.04480381,0.009122053,-0.057363078,0.01623753,0.101986155,-0.0049418276,-0.049878296,0.0348244,-0.03601433,0.039225888,0.036416855,0.034842163,0.07337773,0.055426307,0.09328726,-0.0044746576,0.03763588,-0.10760435,-0.073641434,0.017688885,0.06592831,-0.078137584,0.035448972,-0.014017131,0.025960168,0.041846562,-0.049860444,0.04584384,-0.08275437,-0.005532711,0.045847017,-0.0866664,-0.053050414,0.07120799,-0.013053008,0.09647136,0.037495553,-0.078466125,0.10709722,0.067720786,-0.019950874,0.060926314,-0.04091302,0.05190292,0.10055793,0.0016049758,0.028859327,-0.018611152,0.04674582,-0.020602876,0.028014962,0.06390356,-0.067302324,-0.118935905,-0.0005078521,-0.014049427,-0.05237916,-0.057468753,0.0037920997,-0.010394765,0.041697808,-0.03274449,-0.0691556,-0.010651426,0.025645074,0.0042057605,-0.033176523,0.0492804,0.052660376,-0.08689645,0.0040394384,-0.004957355,-0.032545265,-0.046749473,0.012004166,-0.016938468,-0.00039671286,0.024854194,-0.055979207,0.05638222,0.06690762,-3.1140664e-33,0.1261856,-0.0905638,0.08315747,-0.024538608,-0.07141782,0.048807494,-0.062313158,-0.0681589,-0.016721178,-0.00470167,-0.009983,0.0013965997,-0.0033103633,-0.015460578,0.03745858,-0.072465666,0.010347026,0.08597837,-0.0879884,0.0068161944,-2.2325674e-05,0.082079,0.04999402,0.04762907,-0.0074668135,-0.055627707,-0.00022037502,0.028443748,0.0018590797,0.05652234,0.043178096,-0.04784547,-0.04926088,-0.057278115,-0.062123075,0.03851035,0.05699974,0.055977494,-0.0068449103,0.039583784,0.034256853,0.027327567,0.0069711516,0.050933585,0.00902835,0.0047305524,0.037415564,-0.052312825,-0.046645675,-0.11258738,0.0060568424,-0.014127161,0.046493653,-0.037021574,0.022975583,0.035359878,0.032683156,0.031307198,0.09139482,-0.028783564,0.006016724,-0.09469161,0.010745335,-0.055915125,0.08648158,-0.005168217,-0.015925882,0.10169347,0.12847663,-0.12298871,-0.010874005,0.01765779,-0.0055200653,0.12745242,-0.041694954,0.018377302,-0.055195317,-0.102477536,0.034097943,-0.04269354,-0.011818728,-0.05329146,-0.0037755785,-0.04227787,-0.053357795,-0.05378159,0.022718946,0.07676889,-0.004981812,0.03757876,-0.029046055,-0.046539374,0.00742384,0.09027833,0.042980988,-4.144228e-08,0.043940045,-0.012908563,0.054605983,0.03585179,0.0069792564,0.021250151,-0.09062541,-0.006756098,0.061369587,-0.070857435,-0.039779693,0.036231544,0.01357235,0.07234115,-0.04421739,0.06967778,-0.006757445,0.021744272,-0.018836165,0.03486644,-0.06760705,-0.013310112,-0.05636782,0.065870054,0.09693524,-0.12650871,0.00841537,0.0649803,-0.022600397,-0.014344004,-0.002440916,0.0275796,-0.007726191,-0.05709676,-0.025392871,-0.028915802,-0.020029008,-0.024596738,0.04332357,0.0030037065,-0.026826017,-0.0018832562,-0.025788905,-0.02767786,-0.113314226,0.047042083,0.019333437,0.009691062,-0.11092115,-0.06261809,0.09143998,-0.039464694,-0.017799867,-0.01957482,-0.07817583,0.04829365,-0.0393251,-0.04069395,0.0051932978,-0.028001433,-0.045038164,0.050772823,0.07564262,-0.062080845 +6.3.4.2,"The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2, glutaminase), and the active site where CTP synthesis takes place. The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP [4,5]. Ammonia then reacts with this intermediate generating CTP and a phosphate. The enzyme can also use ammonia from the surrounding solution [3,6].",384,1.0,-0.009713148,-0.04184565,-0.022553384,-0.08848441,0.012933511,0.017022014,0.01568551,-0.016055627,0.0031368453,0.018807216,-0.0065396754,-0.02739208,-0.037341196,0.057246972,-0.05642732,0.0062081954,-0.041807644,-0.035406306,0.026676137,-0.026200235,0.052274734,0.063490584,-0.04747002,-0.04780571,0.06262018,0.052802145,0.09554498,-0.025303412,0.03616897,-0.064892486,-0.10884721,-0.06776483,0.020363852,-0.035600986,0.03967158,0.12692332,-0.06388802,-0.051682737,0.06818618,0.005090099,0.039942186,0.020870207,-0.04003825,-0.020439597,0.03232101,0.05715846,0.07360436,0.028013658,0.00838107,-0.038813513,0.048236452,-0.024285654,0.0329394,0.010503859,-0.010716303,0.03469177,-0.09873878,-0.01691728,-0.065095715,0.015229478,-0.0031243798,-0.0041184304,-0.015441635,-0.055021096,0.13005929,-0.013975525,0.037346985,-0.044488948,0.010131759,-0.06243706,-0.089093275,-0.034054745,0.0061284723,0.014790697,-0.038456306,0.01560993,-0.007981273,-0.0083781,0.0672175,-0.02335354,0.08558669,0.019266363,0.08838751,0.08470065,0.06477066,-0.023296464,-0.013166782,0.020314364,0.092056155,-0.008596138,-0.010859874,-0.039356902,-0.016226826,-0.018441932,-0.022668134,0.03830059,-0.012219728,-0.00013956166,0.02258147,-0.071718425,0.013714888,0.065361686,0.021625126,-0.064633094,-0.01622102,0.03259763,-0.054678004,0.09669466,0.010418523,0.012129421,-0.011131929,0.092631795,0.021378214,-0.010963006,-0.0029099542,0.059820045,-0.007943034,-0.08938864,-0.03797943,-0.024446981,-0.018070258,-0.057173252,-0.008510861,0.098903716,-0.10044561,0.04373074,-0.05271631,1.8420896e-33,0.029672122,0.023223834,-0.0076050116,-0.063254885,0.025073947,0.020498466,-0.054510813,0.020154996,-0.017988622,-0.051656324,-0.08790542,-0.04196212,0.04001903,0.0038866317,-0.05216928,0.035611313,-0.04553893,0.010655864,0.07362505,-0.031956404,0.012033123,0.112882756,-0.08181479,0.041443158,-0.029930377,0.100808814,-0.06216924,0.0052711233,0.015175475,-0.027711116,-0.006534182,-0.07628891,-0.14140883,0.07952306,-0.0076218117,0.010861485,-0.05569719,-0.047118112,-0.021543892,0.06055809,-0.0032866674,0.0047480976,0.018623708,0.0023884838,0.025436545,-0.04663494,-0.06376622,0.023178117,0.017737167,0.10276883,0.012057682,-0.0037340284,0.05546969,-0.040703017,-0.07867559,-0.015820313,-0.026019748,-0.047948666,0.042247914,0.094683036,0.025718864,0.011712923,-0.056252662,0.029950632,0.008161477,0.055720426,-0.07914273,-0.10159357,0.09870029,0.1574464,-0.045435015,0.0023286003,0.06459323,0.043211974,-0.029757774,-0.08344616,-0.008842882,0.056302637,0.005212745,0.0675268,-0.011822773,-0.048913628,-0.009728136,0.06416228,-0.04175875,-0.06826783,0.04491782,-0.06698846,-0.0061630076,0.0068886694,0.062331468,-0.008651733,-0.028852334,0.05392287,0.008732618,-3.376697e-33,0.16960597,-0.07181389,0.0008887389,-0.045781758,-0.109822735,0.025216976,0.014190833,-0.066585824,0.014944743,0.044882018,0.06532756,-0.012042672,0.018389812,0.052219592,-0.028082052,-0.003956196,0.043045778,0.08248595,-0.054137886,0.0037877026,0.047999945,0.06871009,0.020608459,0.060584076,0.05793219,-0.049252957,0.04918966,-0.049523216,0.0070443116,0.044386424,-0.044443488,0.007010625,-0.024389219,-0.036067676,-0.018606463,0.011491906,-0.023999041,0.028129105,-0.014436956,0.029329909,0.06311231,0.024389742,0.015554019,0.11557071,-0.028274106,0.12237714,-0.06311454,0.024630085,-0.08133591,-0.03164357,0.07371405,0.0058095143,-0.0077258884,-0.0075592883,-0.002589768,0.047600046,0.029296113,-0.034302413,-0.035492357,-0.025882052,-0.056274805,-0.038347654,-0.0038366774,-0.02292373,0.033789553,0.02000966,-0.0026404595,0.016977297,-0.0363133,0.053818244,-0.032576367,-0.04419424,0.13342893,0.029943481,-0.027415195,-0.008438095,0.0010573049,-0.00993996,0.06426912,-0.13825233,0.024056865,0.0053469376,0.037826728,-0.046297442,-0.020964079,0.017459527,-0.004947749,0.14550269,0.032307453,0.026322993,0.0077991304,0.032517835,-0.06618065,0.041126687,0.048270706,-4.187729e-08,0.010382361,-0.035065483,-0.0155365225,-0.0920321,-0.031866077,0.12939858,0.03804384,0.03279254,0.027324023,-0.04451695,-0.03064863,0.07047233,-0.06859902,-0.033663765,-0.009880927,0.036792587,-0.07652636,0.020376464,-0.03617243,-0.034738477,-0.120655,0.004898725,-0.10849377,0.03362529,0.062065326,0.008575213,0.023225425,0.042178232,0.009976348,-0.04224409,0.04522104,-0.009150469,-0.019063203,-0.07839083,-0.067464106,0.011511643,-0.012796433,-0.016804967,-0.0496773,0.01405527,-0.0142864045,-0.043529563,-0.019635549,-0.013737479,-0.001009084,0.06775601,-0.010736387,-0.028374944,0.004436809,0.008123161,0.018052582,-0.051942028,0.02438623,-0.049382914,-0.085434385,-0.024279978,-0.039143544,-0.13757429,-0.025111139,-0.028170802,0.000727085,0.07250958,0.09346537,-0.016702479 +6.3.4.3,In eukaryotes occurs as a trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity.,384,0.99999994,-0.05484812,-0.037343398,-0.084700316,-0.061479103,0.012396224,0.036698963,-0.09317099,0.02847014,0.024144853,0.0053876447,0.047648605,-0.114495456,-0.066457205,0.041171394,0.0071972124,0.0324202,-0.085865006,-0.00613017,0.054417506,-0.054916143,0.04559598,0.05934235,0.009123107,0.00043755496,0.0043629897,0.0007127773,0.024786713,0.02051266,-0.0040537952,-0.04100214,-0.012123212,0.033145748,0.004460944,-0.023760023,0.013444259,0.11633059,-0.06701149,-0.077667765,-0.0005068376,0.0213477,0.03798716,0.0150744775,-0.044847533,0.014727817,-0.027043471,0.033079147,0.041692823,0.017614275,-0.010500422,-0.027316537,-0.03337336,-0.007959073,0.021271262,0.0021171938,0.010067479,-0.044986658,0.010342159,-0.0028663327,0.010358964,-0.052541167,-0.015617182,-0.014893212,-0.0022597956,0.017230975,0.054735295,-0.030258596,0.08522296,-0.088234715,-0.04349616,-0.027419426,-0.0968592,-0.07712259,-0.034245122,0.076607175,-0.08818557,0.057677276,-0.034586035,-0.08423656,0.019060565,-0.036620554,0.01930483,0.013845165,-0.009936452,-0.024392394,0.03489192,-0.048647515,0.004749739,-0.020264216,-0.011224126,0.008929356,0.018687291,-0.011723371,-0.051159706,-0.01491798,-0.11357401,0.039574943,0.10898566,0.068720825,0.05818799,-0.085212424,0.029576048,0.06762448,-0.019715805,0.0094246585,-0.026778536,-0.0048431032,0.005648991,0.07189532,-0.048425093,0.030446116,-0.05464696,-0.050566226,0.03034366,-0.039272226,0.013889257,0.057118077,0.033638887,-0.06497545,-0.015322976,0.014283113,0.016243685,-0.047136024,0.092520535,0.07456322,0.012586572,0.063447215,-0.135971,4.5952543e-33,0.05565331,-0.006147477,-0.028767077,0.025305925,0.004385774,-0.0044990936,-0.061828565,0.049817547,-0.036200985,-0.07497976,-0.09629701,0.0040785926,0.09633655,-0.008137655,-0.033723027,0.016435161,0.008361288,-0.04857843,0.029067459,0.03771653,0.015926743,0.04138473,-0.011035151,0.0014650339,0.00083703094,0.035962585,-0.00024763524,0.00064927165,0.036610533,-0.0029569413,-0.005429972,-0.17698278,-0.14149879,0.027548159,0.09265289,0.052268513,-0.00933507,-0.05599615,0.007948117,0.019532392,-0.018146966,-0.03433846,0.0386192,-0.10470351,0.04761331,-0.027542116,-0.06803361,0.072161876,-0.02379097,0.013704651,0.021557836,-0.028355148,0.11726541,-0.08508821,-0.051421676,0.092382506,-0.0015509068,-0.030627023,-0.0015005543,0.14297393,-0.041345123,0.048107386,-0.064762905,0.026076049,-0.012231914,0.0081252605,-0.071991965,-0.06782413,0.027246295,0.014036519,-0.028634667,0.0008956081,0.17972124,0.042781714,0.055034053,0.006683713,-0.04174296,-0.050282214,-0.0036375432,0.074761234,-0.0014404379,-0.06288409,0.0064747278,-0.030677242,0.02643121,0.029254632,-0.014167684,-0.030328013,-0.013280243,0.034212507,0.046908464,-0.09209739,0.019873306,-0.025847953,0.039130922,-6.568711e-33,0.08394357,-0.020227129,0.039668083,-0.13473053,0.026031455,0.12626155,0.00315905,-0.070988216,-0.019105377,-0.03729042,0.10503678,-0.030062987,0.035912074,-0.024504887,0.019164288,-0.0001397329,0.0075285533,0.123089895,0.014279059,0.024068264,-0.005457505,0.02697264,-0.012565576,0.022411345,0.054189913,-0.024854764,-0.02967561,0.050189525,0.0049975794,0.01497431,-0.08269902,0.03163501,-0.047990046,-0.031430777,-0.00093108625,0.025595652,-0.070005916,-0.0192543,-0.01188953,0.042153962,0.017197572,0.06558696,-0.014771336,0.07345487,0.047277886,0.04432972,-0.112369135,-0.005527897,0.014884665,-0.036092788,0.024243612,0.02221415,-0.028772665,0.026252743,0.03731294,0.08421544,0.07274221,0.06557587,0.07233858,0.0011645455,-0.033388976,-0.0422758,0.05141297,0.016181955,0.03055989,0.026994735,-0.06785156,0.026851496,0.009587608,0.014840072,0.043161195,0.022512097,-0.005937404,-0.04628791,-0.05687078,-0.011038964,-0.061485626,-0.017188821,-0.008329196,-0.019940369,0.08663024,-0.023986332,0.020790875,-0.033545006,-0.052762706,-0.0647193,-0.0018130317,0.049489304,-0.0449045,-0.029276066,-0.028367475,-0.009856649,-0.09389047,0.07054924,0.05213757,-4.3242775e-08,-0.0012209197,0.013854878,0.039186083,-0.090082295,0.08621456,0.034155715,0.032528598,-0.010005808,0.04727237,0.006297306,0.0023611183,0.06377142,0.040604774,0.014214181,0.0583347,0.04575152,-0.013940109,0.042429265,0.02195775,0.048465133,-0.007237678,-0.0047407,-0.0812144,0.076786175,-0.02145837,-0.04559459,0.031982213,-0.0049196286,0.08097588,-0.039047252,-0.057751287,0.0385674,-0.012417624,-0.051835302,-0.05942548,-0.0065288283,-0.039422303,-0.04419193,-0.09391572,0.06680061,-0.00038352457,-0.044646483,-0.09104061,0.028531358,0.046031985,0.03408409,0.036438633,0.0035452552,-0.03671776,-0.06158899,0.003927041,-0.017964814,0.047614686,-0.06004379,-0.058367684,0.011032534,-0.040908787,-0.124254264,-0.049345657,-0.005414485,0.009495731,0.01963964,0.20475017,-0.033215985 +6.3.4.6,"A biotinyl-protein. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 3.5.1.54 allophanate hydrolase, thus bringing about the hydrolysis of urea to CO2 and NH3. Previously also listed as EC 3.5.1.45. The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates [4].",384,0.99999994,-0.053763993,0.0059874486,-0.061637882,-0.022535078,0.0710246,0.05179586,-0.02927282,-0.007889877,0.040051766,0.028959678,0.024352385,-0.11845762,-0.15706187,0.018176222,-0.015321076,0.008228624,-0.090576425,-0.0041910876,0.02543012,-0.051703095,0.12749286,0.08068856,-0.0007390837,0.010385718,0.0323263,-0.0036298563,0.04210221,-0.020470465,0.012042533,-0.12855963,-0.01343701,-0.06885212,0.028975382,-0.06194827,0.0403407,0.036617845,-0.05789735,-0.14197686,0.022014974,0.034185987,0.036775414,-0.009698593,-0.018112194,-0.08484148,-0.025450338,0.0043160794,0.058540978,0.00699071,0.029831005,-0.053715546,-0.06620131,-0.08717378,-0.037777085,-0.037414044,0.041593794,-0.05102256,-0.031515907,-0.062167153,0.008304196,-0.028061062,0.054201975,-0.018683065,0.027499208,-0.021329634,-0.017485462,-0.0747052,0.011354401,-0.103099264,0.00054194813,-0.007984057,-0.12496336,-0.08721061,0.002226741,0.05705963,0.02574222,0.0026897485,-0.005745942,-0.06364484,0.024535399,0.035498437,0.014673065,-0.0056771575,-0.02208454,0.043096315,0.061113004,-0.031628072,0.018930286,0.044082794,0.044119872,-0.009755332,-0.002829862,-0.024220172,0.035489827,0.03126647,-0.025454516,0.056575797,0.0050357487,0.01152756,0.042328645,-0.03981538,0.013787034,0.08279246,-0.03750043,-0.11423178,-0.022078631,0.067111135,0.08607448,0.17309007,0.040386178,0.01672031,-0.046629325,-0.07240473,-0.012980685,-0.0013288653,-0.05049275,0.05874908,0.037614647,-0.10670531,-0.03573331,-0.008649474,0.0123731885,-0.02835242,0.04539028,0.104473315,-0.064099856,0.07851461,-0.10873281,1.6848581e-33,0.07884292,0.01424235,-0.0765402,-0.040186178,0.004641954,0.0019479482,-0.06472601,0.0007663957,0.017943975,-0.09570738,-0.077531636,0.036646307,0.039345976,0.032872252,-0.037044197,-0.04085797,-0.008408395,0.026401749,0.031569418,0.038942195,0.033900943,0.00970983,-0.05506898,0.03711337,0.07455937,0.01614055,0.024193466,0.004517451,0.05536977,-0.02386716,0.029330771,-0.10846689,-0.08744343,0.011890748,0.08467129,0.011879806,-0.0019565516,0.007453822,-0.044891585,0.07996949,-0.008906477,0.028034145,-0.003203705,-0.054754246,0.042453513,-0.008419444,-0.05131715,0.11181032,0.035340786,0.038952734,-0.013165125,-0.021651814,0.10580641,0.011875885,-0.071900494,0.026865415,-0.047307722,0.019146636,0.015532015,0.03834375,-0.0739241,0.07325445,-0.027462885,0.05077402,-0.05239327,0.05774549,-0.009788634,0.00390165,0.04586491,0.01949848,-0.08582965,-0.00062411313,0.0659512,-0.0042848806,0.011884751,-0.087955855,-0.092669465,-0.03858699,-0.03314546,0.09596796,0.00790988,-0.03056708,0.0370956,-0.021062523,-0.038115963,0.009368205,-0.034079477,0.015319297,0.010789448,0.016918644,0.035841897,-0.06547463,0.004071113,0.047867306,-0.042623054,-3.1486325e-33,0.15836239,-0.11714677,0.061178952,-0.06824824,-0.03435233,0.06276203,0.018719425,-0.03011449,-0.033496045,-0.017740829,0.0560621,-0.015834935,0.084135786,-0.06563826,0.03897953,-0.04370315,-0.05229951,0.04264798,0.033766877,0.03436627,-0.01915576,0.042177502,-0.0011113879,0.03897003,0.07539899,0.039758373,-0.0028297158,0.02527452,0.03317395,-0.030286714,-0.057578985,-0.010031572,-0.016027262,-0.0613205,-0.041949842,0.064803466,-0.03329616,0.0384529,0.01632003,0.03513676,0.06826868,-0.03311002,-0.021077197,0.06372721,0.013467463,0.07671778,-0.05357185,0.031091483,-0.051819652,-0.01958406,0.056123752,0.004783083,0.008234445,-0.013019806,0.03147529,0.05712854,0.035452563,0.028326176,0.015338631,0.05071035,0.009825541,-0.03724293,0.0802576,0.008940861,0.021595292,0.039563254,-0.10080543,0.0057315067,0.0017413455,0.04876971,0.054353636,-0.00015490796,-0.002023088,0.023747554,0.005182007,-0.008031991,-0.09656832,-0.06461798,-0.013417002,-0.038104802,0.032135163,-0.03194331,0.05177539,-0.054552376,0.022392364,-0.021505594,0.04912909,0.061988264,-0.06816714,0.068222135,-0.050827846,-0.052331697,-0.042980988,0.09415729,0.012249116,-3.9826553e-08,0.030108426,0.004687625,0.077135645,-0.03295132,-0.014825384,0.0587974,0.078984335,0.038644724,0.060921814,-0.010173358,-0.02971416,0.052493867,0.051857576,0.049504492,0.048172977,-0.017459411,-0.023645181,0.0071743345,0.00934088,-0.0010957974,-0.05075005,-0.041376505,-0.08648887,0.0701402,0.015788795,-0.051594157,0.03837882,0.07819193,-0.025519853,-0.0757719,-0.05013604,0.034047104,0.0151524,-0.009502136,-0.029373301,0.028061936,-0.044110313,-0.08966159,-0.06776825,0.029972686,-0.0007556585,-0.0047941417,-0.05454806,-0.042598255,0.01000673,0.008728652,0.027520984,0.021776965,-0.012410695,-0.029753717,0.07486419,-0.05476777,-0.04523659,-0.0391815,-0.062140852,-0.013188604,-0.02535349,-0.07983539,-0.0363087,0.02607095,0.081974715,-0.016046308,0.15255752,-0.020690687 +6.3.4.14,"This enzyme, part of an acetyl-CoA carboxylase complex, acts on a biotin carboxyl-carrier protein (BCCP) that has been biotinylated by EC 6.3.4.15, biotin---[biotin carboxyl-carrier protein] ligase. In some organisms the enzyme is part of a multi-domain polypeptide that also includes the carrier protein (e.g. mycobacteria). Yet in other organisms (e.g. mammals) this activity is included in a single polypeptide that also catalyses the transfer of the carboxyl group from biotin to acetyl-CoA (see EC 6.4.1.2, acetyl-CoA carboxylase).",384,1.0,-0.067445174,-0.05503449,-0.03703861,-0.010335287,0.0657673,0.064200595,-0.04391469,0.044299085,0.04312151,-0.03988635,-0.011366094,-0.06647456,-0.07115369,0.052555792,-0.052211422,-0.014218751,-0.07769418,0.011153683,0.020598672,-0.015591086,0.033161346,0.016385395,-0.004388647,0.01850297,-0.01282786,-0.05622789,0.022948844,-0.027425978,-0.021420421,-0.08606337,-0.024807012,-0.023657281,-0.0015968021,0.052614313,0.036627624,0.09272785,-0.0031249889,-0.10251427,0.07248352,0.011176563,0.07344898,-0.027555894,-0.019328814,-0.0405787,0.027788103,-0.051572427,-0.06360818,-0.055701688,0.06342945,-0.033509854,-0.007985863,-0.0030694373,-0.022778725,0.054394174,0.008822873,0.03359679,0.0080756815,-0.05731378,0.03399016,0.0040723057,0.061574794,-0.009663826,0.003743786,0.0088168075,-0.0068644914,-0.10253875,0.01589489,0.003951125,-0.0008012109,-0.0481312,-0.05674217,-0.06762925,-0.064218745,0.08091354,0.040618062,-0.019260343,-0.06374497,-0.023119614,0.022072844,0.03323205,0.016587233,-0.012926954,0.0018389593,0.033065632,0.02606204,-0.014515873,0.026287325,0.019956317,-0.074681826,0.055227954,0.041027725,-0.06708182,0.056374326,-0.04294898,-0.08596476,-0.04677069,-0.012586823,-0.0295192,0.026820602,-0.04264747,-0.0204457,0.033016652,-0.028804723,-0.074326396,-0.028163584,-0.0140422555,-0.030047502,0.13854991,0.13010365,-0.0042034388,-0.06493513,0.011343807,0.037968762,0.005810554,-0.04278446,0.1207837,-0.076098114,-0.03922798,0.03458847,0.05289559,0.015666187,-0.07312441,0.046899565,0.06025038,0.027895983,0.0057522026,-0.07692761,6.0698855e-34,0.07099586,-0.032900874,0.05431867,0.032028854,0.009282224,-0.017696906,-0.08658516,0.00815404,-0.022823256,-0.05629012,-0.0393741,-0.05439169,0.02351173,0.057660367,0.0046811947,-0.026051316,-0.10707924,-0.038875658,0.074249536,0.061802126,0.034224987,0.07045434,-0.05016684,0.081815794,0.06419484,-0.02020764,-0.064953335,0.057142638,0.058449905,0.0273452,-0.026086163,-0.041618343,-0.060552828,0.031247297,0.052725017,-0.029861534,0.046818938,-0.120631635,0.028495453,0.108087204,0.06859023,-0.053035695,-0.018169742,-0.06289788,0.0615676,-0.05261791,-0.058397613,0.060518757,-0.021549214,0.06541667,0.053796943,-0.05764643,0.07096388,-0.06649239,-0.04187544,0.026267571,-0.11949935,-0.021190645,-0.0047475877,0.053775556,0.060890097,0.03146033,-0.03823113,0.003675962,0.010480825,0.035704747,-0.0672717,-0.01521767,-0.029740892,0.059042655,-0.0404647,0.010366538,0.03891828,-0.017422922,0.06867031,-0.01252164,-0.11835029,0.078177914,0.02719746,0.0061383694,-0.0142655345,0.043325,0.016102353,0.0025177377,0.0042555174,-0.009827252,0.03151276,-0.054074127,-0.020168245,-0.022306139,0.052646343,-0.06824304,-0.018755449,0.07822133,-0.042700786,-3.6890594e-33,0.09650452,-0.13973413,0.063065894,-0.09070163,-0.055079002,0.08200012,0.08361805,-0.017015716,0.017294934,-0.01033178,0.07129845,-0.011086081,0.029342448,0.00076380325,0.018314423,-0.021230346,-0.07776378,-0.022712579,-0.041633874,-0.016107926,-0.038500085,-0.038474556,0.08076824,0.037556823,0.052020915,0.015556171,-0.12565525,0.074175976,0.056071542,0.008621665,-0.00925623,-0.008952717,-0.03705462,-0.04291221,-0.07464702,0.059543736,-0.051918823,0.019233523,0.042805795,0.00422349,-0.043846674,-0.012994066,-0.060414184,0.0036984303,0.06345708,0.011409938,-0.024216317,-0.014682328,0.04158782,0.00016873676,0.010163346,0.045029707,0.016664553,-0.0493181,-0.06839335,0.086442575,0.06075442,-0.0032219482,0.060494345,-0.0442359,-0.0065228776,-0.005097673,0.027926177,0.02575671,0.032652576,0.08421479,0.003021457,0.060109537,0.08596744,-0.10646751,0.09452552,0.02943268,0.070960484,0.038088262,0.01603708,-0.03226799,-0.04242999,-0.05592491,-0.0158958,-0.005264396,-0.076868586,-0.029543282,-0.028231833,-0.06525819,-0.051628828,-0.05215404,0.040233858,0.041280184,0.00026152827,0.015000443,-0.07296045,0.043281883,-0.021606348,0.031540904,-0.033678357,-4.659859e-08,0.092769794,-0.040405847,0.009518309,-0.08643619,0.05470555,0.012311693,-0.049506333,-0.05237778,0.018979277,-0.020752817,-0.047377147,0.090586476,-0.03677181,0.043083988,0.04709894,0.010485688,-0.028500581,-0.031411815,0.027582927,-0.019614918,-0.102435276,-0.0005698822,-0.026734145,0.08370636,-0.019041587,-0.06528454,0.044137113,0.112500474,0.034038417,0.003113978,-0.030829357,0.03004871,-0.022330888,0.019138232,-0.039669134,0.039497033,-0.066342466,-0.04230936,-0.013381799,0.056951266,0.06350388,-0.05251766,-0.041326154,0.013835141,0.11538871,0.008590852,0.011479087,0.042259388,0.015971355,-0.013313492,-0.0015922772,0.006419427,-0.082848564,0.009377456,-0.0146345245,-0.019735161,-0.034604587,-0.1131366,0.085317954,-0.032933477,-0.025907626,0.024322616,0.17011957,-0.0054241517 +6.3.4.15,"The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14, biotin carboxylase. The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15, acetyl-CoA carboxytransferase. In some organisms the carrier protein is part of EC 6.4.1.2, acetyl-CoA carboxylase.",384,1.0,-0.06220737,0.002754838,-0.02389408,0.012163981,0.094820134,0.09131477,-0.08223427,-0.0025433819,0.02617011,-0.0733792,0.037014432,-0.033681665,-0.107773036,0.0041041654,-0.032682955,-0.047998223,-0.0846062,0.06971134,-0.0160909,-0.04456183,0.02807791,0.020821853,0.02410051,0.02512221,0.020517994,-0.040339008,-0.014290982,0.0104100695,0.015123262,-0.10443353,-0.014877193,-0.020158842,-0.012051444,0.029757915,0.011194181,0.09135186,-0.003936538,-0.11377026,0.07343482,0.0010782402,0.06930893,-0.030665727,-0.016682757,-0.04362454,0.038321476,-0.08932021,-0.016676165,-0.04961929,0.05913304,-0.045136496,0.012475673,0.009465813,-0.025951471,0.032565884,0.040991277,0.032795057,0.03266527,-0.05182134,0.005845801,0.016066004,0.09175865,0.014458389,-0.0075824223,-0.027295103,-0.03100489,-0.08678843,0.028716752,0.00024233403,0.030319687,-0.0056302543,-0.07152118,-0.059471894,-0.011180105,0.08962254,0.027944483,0.000967046,-0.080267675,-0.010419877,0.033378053,0.051161624,0.012969918,-0.045416668,-0.025560755,0.045413207,-0.009918325,-0.055105828,0.03524889,0.048072472,-0.08964992,0.010414767,0.009110597,-0.047218688,0.07716454,-0.0040402045,-0.08899488,-0.01373432,-0.014550425,-0.012073933,0.03931152,-0.04226367,0.0066236416,0.06009209,-0.018926533,-0.051770035,-0.016569408,-0.053320613,-0.03543896,0.1318052,0.046282545,0.0024104365,-0.039632156,-0.023753915,0.045260757,-0.017520603,-0.07852384,0.119006604,-0.13208276,-0.040692113,0.057787813,0.056007843,0.052727185,-0.011072738,0.08646022,0.095157586,0.05009279,0.010754589,-0.091969565,3.6347982e-33,0.049155284,0.0044903294,0.04095082,0.08034963,0.0038107452,-0.031819765,-0.101645276,-0.008404607,0.018899404,-0.040588308,-0.05811438,-0.036467362,0.00846424,0.028142024,0.014532705,-0.071508035,-0.13496815,-0.07639044,0.052270707,0.06896203,0.011639242,0.06637788,-0.062339045,0.08876248,0.05223124,-0.026911912,-0.06395522,0.032675494,0.07115244,0.03344911,-0.036958218,-0.055208974,-0.04055278,0.0011193311,0.052671347,-0.032974098,0.04918356,-0.084533945,0.038370565,0.09245839,0.10633391,-0.006641107,0.012331408,-0.052207332,0.054890525,-0.024968984,-0.020018652,0.06624242,0.027433114,0.059750408,0.0060369805,-0.08263642,0.05629089,-0.066948324,-0.031088233,0.03880011,-0.117824346,0.0031102735,0.020264206,0.05980712,0.052933723,0.0020798594,0.013016952,0.001483231,0.031722996,0.073599055,-0.10294733,-0.022719972,-0.07047556,0.057579868,-0.048082653,0.02602495,0.05551071,0.025585348,0.094052695,-0.0138312075,-0.08451403,0.051423118,-0.02128856,-0.0049131485,-0.020946402,0.05408625,-0.0015306936,-0.030114379,-0.0032754538,-0.029656585,0.00061720266,0.030507203,0.01583332,0.028809287,0.045746878,-0.06719896,-0.00049164344,0.06293232,-0.035350684,-4.7475083e-33,0.10818066,-0.10750464,0.06512827,-0.058029503,-0.050009552,0.06997571,0.06354684,0.0008434025,0.0047757584,0.04271172,0.046054587,-0.018554224,0.056104705,-0.010231685,0.020494597,-0.014083651,-0.091760315,-0.059990168,-0.015240999,0.04570279,-0.050859056,-0.066399574,0.043365505,0.05059513,0.044790693,0.019138433,-0.082715,0.057754416,0.04981083,-0.03743733,-0.0076005375,-0.0409486,-0.06010667,0.008034946,-0.11258873,0.03976531,-0.00052998366,0.026599972,-0.012701731,0.029207706,-0.023725733,-0.035336815,-0.09051031,-0.0028926358,0.092206255,-0.005358361,-0.009048187,-0.017495794,0.019520922,-0.035071086,0.021962667,0.039989736,-0.005587324,-0.02017692,-0.08107875,0.0929207,0.06773201,0.03848918,0.067987286,-0.0056446716,0.0013453132,-0.035897087,0.030742902,-0.0152152935,0.014443363,0.03378251,-0.041539863,0.070223406,0.051702097,-0.052823458,0.08452403,0.020947486,0.09292966,0.047080535,0.069144994,-0.04226322,-0.05401584,-0.027728155,-0.011990589,-0.049977142,-0.053076807,-0.014032527,-0.025434982,-0.06586088,-0.04078842,0.011477765,0.03780759,0.0510511,-0.030775134,-0.012551459,-0.05368491,0.016007116,-0.03149151,0.022834653,-0.062293205,-4.076905e-08,0.08098169,-0.056053102,0.031683277,-0.07907386,0.033692375,0.052586123,-0.010642963,-0.0009000696,0.014981733,-0.021298153,-0.0411663,0.09106066,-0.047987286,0.023071256,-0.03145083,0.024396341,-0.03280126,0.027324848,0.037114497,-0.0022520816,-0.066519246,0.01532255,-0.031126179,0.07936256,-0.025138509,-0.026529828,0.042340852,0.09010332,0.030011518,-0.04650622,-0.03639896,0.008370161,-0.00848623,-0.00048732472,-0.035676565,0.0042021833,-0.054408077,-0.042164482,-0.0299132,0.068200395,0.07615052,-0.051359586,-0.07142168,-0.008096107,0.09411912,0.0004411373,0.047376756,0.045335736,0.009190795,-0.024268758,0.027117653,-0.012508749,-0.08642406,-0.02928222,-0.045392606,-0.05386448,-0.026586203,-0.09792807,0.05114041,-0.019363103,-0.050477404,0.008850128,0.15194687,-0.0032227172 +6.3.4.16,"The enzyme catalyses the first committed step in the urea cycle. The reaction proceeds via three separate chemical reactions: phosphorylation of hydrogencarbonate to carboxyphosphate; a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate; and the phosphorylation of carbamate forming carbamoyl phosphate. Two moles of ATP are utilized for the synthesis of one molecule of carbamyl phosphate, making the reaction essentially irreversible. The enzyme requires the allosteric activator N-acetyl-L-glutamate. cf. EC 6.3.5.5, carbamoyl-phosphate synthase (glutamine-hydrolysing).",384,1.0,-0.053828828,-0.0030393254,-0.019964855,-0.025464913,-0.059906088,0.053692535,-0.07251244,0.0055627683,0.029773246,0.016632698,-0.009430012,-0.030108651,-0.031682726,-0.0133650275,-0.079993926,-0.019944942,-0.081661254,0.006353498,0.01395887,-0.036029693,0.15543757,0.052499786,-0.044126812,-0.082563624,0.072493166,0.0199811,0.08282941,-0.034314707,-0.0022918645,-0.08356618,-0.05028062,-0.08773556,0.0108872205,-0.054557454,0.05110327,0.07496692,-0.108166404,-0.051098444,0.07902406,-0.016245663,0.038010243,-0.042253096,-0.041975327,-0.059370983,-0.034326743,0.025920779,0.057523765,0.05105036,-0.014894343,-0.051241312,-0.04676845,-0.06463493,-0.007930945,-0.028868431,0.0305074,-0.004992391,-0.104035586,0.03083743,0.0053378423,-0.02523936,-0.008486085,0.0040368373,-0.011885756,-0.04917723,0.0943171,-0.07374595,0.03599336,-0.07835236,0.046885256,-0.03224909,-0.11585387,-0.028039966,0.028739575,0.003708791,-0.052425735,-0.0031795055,-0.046492342,0.040701512,0.05099009,-0.019883882,0.07206937,-0.07480626,0.027804043,0.032163873,0.05069247,-0.026138434,-0.0032701837,0.064332746,0.07963807,-0.004544866,-0.0028572876,-0.021758454,0.039359394,-0.04029332,-0.032631878,0.009505338,0.0054198294,0.0010814985,0.03462857,-0.048303813,0.03936041,0.082906835,0.053027235,-0.1002294,-0.002060338,0.055474415,-0.035391014,0.117254905,0.027683811,0.018620891,-0.05862229,0.03439691,0.044244196,0.006193461,-0.08841753,0.056660626,-0.015753923,-0.060894974,-0.072522804,0.02904997,0.006287611,-0.043124136,0.030358614,0.0643282,-0.10290402,0.034719102,-0.026963372,5.6880544e-33,0.06966467,0.02523226,-0.016541084,-0.04479153,0.016254118,0.019470103,-0.007879451,0.016465558,0.023016904,-0.091660686,-0.028271731,-0.06395993,0.029053401,-0.014965282,-0.09522675,0.014177767,-0.057713054,0.050784566,0.081941664,-0.03666234,0.022996629,0.054872278,-0.028954526,0.008507523,-0.031034132,0.07630206,0.014137825,0.00082737807,-0.011510975,-0.0057809944,0.05000967,-0.080202214,-0.12477702,-0.0055235904,0.051659998,-0.06354452,-0.0064239395,-0.014509882,-0.01852841,0.030205917,-0.05460566,-0.0004589887,-0.006959062,-0.03701296,0.0402206,-0.009181576,-0.060051765,0.082177274,-0.00843235,0.13701162,0.026003096,-0.07277714,0.08996702,-0.020626353,-0.072607964,0.013401995,-0.044041075,-0.06388524,0.004882018,0.06769111,0.035676487,0.10853962,-0.00919622,0.021943063,-0.038761295,0.020949295,-0.08368019,-0.04540292,0.033864785,0.12472602,-0.037320025,-0.028106574,0.04145113,0.0024456384,-0.043131564,-0.031781945,0.010941359,0.008078417,-0.007690571,0.0014799165,0.0001898731,0.028889328,0.016721962,0.016315665,0.005915646,-0.030390527,-0.03386764,-0.077864915,-0.05841787,0.046754148,0.058284566,-0.03635014,-0.0469633,0.051414166,0.024617905,-5.895697e-33,0.21380234,-0.06217259,0.06886129,-0.017364215,-0.010390528,0.015498988,0.049795013,-0.044513308,0.022745889,0.026882771,-0.024428016,0.009026367,0.09192442,-0.022118028,-0.008781528,-0.04193638,0.073163435,0.05135983,-0.043890428,-0.010538414,0.012635886,0.077720135,0.011799982,0.037875883,0.024662312,-0.027975652,-0.011079868,0.0057921633,0.042290065,0.05324515,0.06325542,-0.026710033,-0.0285079,-0.07544233,-0.049413443,0.08357446,-0.028641565,0.044127062,0.051611587,0.012770902,0.053322595,-0.016150082,-0.02622697,0.04883677,0.034837432,0.026491262,-0.047861215,-0.02860625,-0.08444222,-0.08260081,0.06256093,0.009245563,0.018408826,-0.020255463,0.047303718,0.06466022,0.050878998,-0.04133009,-0.06264376,0.034375213,-0.01613278,-0.04193668,0.057234142,-0.038409483,0.017400838,0.014379122,-0.03601475,0.054415766,0.059485123,0.016370816,0.06516015,-0.007347774,0.027556721,0.027943866,0.010159162,0.025906375,-0.016723605,-0.049286406,0.026045255,-0.11912756,-0.0027627219,0.008038461,-0.017557457,-0.051535238,-0.015270481,-0.062571846,0.057520308,0.11964128,0.0158535,0.062465716,-0.046840593,-0.01413318,-0.015185401,0.11810874,0.05215807,-4.2141398e-08,0.017440746,-0.009952662,0.050658166,-0.021665363,0.030769264,0.091479644,0.03463623,0.026990108,0.0757499,-0.0625306,0.012251131,0.034170497,0.025244812,0.04686086,0.028831333,0.034600623,-0.07728758,0.034456015,-0.06704341,-0.012850904,-0.08076884,-0.03954789,-0.12218559,0.055615574,0.118642226,-0.05883339,0.05023069,0.0460443,-0.073418364,-0.0090069305,0.023039462,0.03320916,0.0066563636,-0.02444152,-0.10187553,0.02972574,0.009605875,0.01844758,-0.018817917,-0.029491955,-0.037259,0.019372452,-0.03705677,0.03526585,-0.0071918955,0.056984905,-0.040662527,-0.0070517287,-0.066585585,0.012158029,0.013898086,0.009233251,-0.049043506,-0.05211955,-0.07911204,0.027294625,-0.009434498,-0.06862809,0.01709589,-0.02667807,0.09283883,0.059520252,0.1025244,-5.8014804e-05 +6.3.4.17,Not identical with EC 6.3.4.3 (formate---tetrahydrofolate ligase).,384,1.0,-0.009127445,-0.0537669,-0.04439259,-0.05421809,-0.017305769,-0.042359214,-0.08704398,0.05934236,0.071448214,-0.06768416,0.107616104,-0.03777341,-0.06356166,-0.00069724716,-0.0155028,-0.09310935,-0.11222153,-0.07306596,-0.02893987,0.022902608,-0.014904895,0.014343213,0.014311581,0.027675437,0.055573437,-0.011201642,0.041562617,0.04024614,0.03575482,-0.08072847,-0.01609141,0.018843705,-0.048479818,-0.045641698,0.06484235,0.016757173,0.018342366,-0.08308203,-0.05095139,0.0039666453,0.03650734,-0.078719586,0.0044177147,-0.0115625,-0.024888681,0.04121249,-0.02704945,0.05151826,-0.038669314,0.0005703719,-0.028579533,-0.124302834,-0.03444799,0.0042490005,0.018135447,0.090806216,-0.058793776,0.020178882,0.0003959132,0.09190379,-0.0062829186,0.036406193,-0.042500682,0.06269966,-0.008515554,0.015009665,0.13810976,-0.11872609,-0.03101771,-0.06536526,-0.060434457,-0.074669495,-0.011447585,0.09997903,-0.016101163,0.12664317,-0.0013859307,-0.03826686,0.010910915,0.013667962,-0.013276774,-0.031614155,-0.023200361,0.009379432,0.04825409,-0.0393247,-0.022247158,-0.067727484,-0.026300868,0.052578893,0.040711816,0.012034497,0.038259655,-0.0067813406,-0.06238544,0.06223698,0.015278559,0.15506135,0.058631085,-0.0266974,-0.04017426,0.070042945,-0.09255729,-0.0184634,0.008466617,0.0068343575,-0.0031008169,0.087793075,-0.017696904,-0.0014958408,-0.013734997,-0.09273869,0.008272206,-0.041253168,-0.08099831,0.07183634,-0.027435692,-0.016885655,0.0975805,0.08640252,0.02276247,-0.011333489,-0.02975546,0.027044928,-0.03988701,-0.009752436,-0.010308121,-1.180944e-33,0.026115632,0.07426674,0.040224157,-0.019282429,-0.009588188,0.04190856,-0.114513636,0.054256465,-0.10706473,-0.04881928,-0.055576924,-0.031401496,-0.008655127,-0.018331788,0.029931504,-0.09295465,0.012150358,0.05972928,-0.056316104,0.08169212,0.061050143,0.08716994,0.02562274,-0.0068221907,0.02140307,0.065923534,-0.018970981,-0.009104133,0.043864965,0.021635734,-0.06812738,-0.092318624,0.017487582,-0.037977416,0.0015077415,0.023758333,-0.015499325,-0.05972221,-0.07981534,0.09052595,0.06749415,0.057110574,0.009245504,-0.055175807,0.015624727,-0.01980465,-0.0008170907,-0.011737236,0.06668337,-0.046051394,0.011501567,-0.006261853,0.03509783,0.008923702,0.024824547,-0.039733678,-0.054478988,0.030637113,0.016011396,0.03468521,0.029960524,0.11449448,-0.0058569256,0.0193896,-0.025706496,0.007475603,-0.009459371,-0.03088067,-0.022985585,-0.03684112,-0.0674347,0.0447126,0.07979867,0.020842887,0.035143405,-0.058226045,-0.069686785,-0.008985899,0.031790543,-0.058310214,-0.07833756,0.051940273,0.057326775,0.0114903785,-0.04326967,-0.019761492,-0.0045841695,0.05615761,0.0055131577,0.047774784,0.11901371,-0.0043022134,-0.021446956,0.012336075,-0.008829135,-1.7021359e-34,-0.016504956,-0.040014178,0.008662976,-0.031241963,-0.033607893,0.073526464,0.06858273,0.068201005,0.03959353,-0.056141905,0.18092106,-0.07287248,-0.014187386,-0.12098286,0.0056626024,-0.052104227,-0.035393097,-0.005081662,0.06735657,0.030623535,0.027342552,-0.012907503,-0.01381407,0.042293306,0.07660531,0.013894047,0.008820363,0.03331523,0.005309455,0.03897383,-0.036694974,-0.027492391,-0.012486982,-0.004469212,-0.069647044,0.051651526,-0.05457976,-0.0052887695,0.10436211,-0.03205438,-0.021169478,0.048699204,0.0055511757,0.048186976,-0.0029381139,0.03728477,0.022049906,-0.042953145,0.044484515,0.013444346,0.029453784,-0.008731248,-0.07485617,0.008899897,-0.032073054,-0.018133122,0.051488686,0.0075190277,-0.094863735,0.012612761,0.025636518,0.013615792,0.028373221,-0.035598736,0.086117595,0.060110703,-0.007063781,0.043105986,0.04040329,-0.02454305,0.07365148,-0.019213919,-0.069235794,0.010197936,0.032891445,-0.09513221,-0.03213468,0.046991646,-0.004816358,0.020551985,-0.027284997,0.038555257,-0.037744913,0.046648,0.077567466,0.0035612923,0.052860413,0.059166238,-0.027646255,0.06640766,-0.047040667,0.04687411,-0.069143966,0.075464,0.06891481,-2.506119e-08,0.1155757,-0.093284056,-0.055588648,-0.049062952,0.05038093,-0.039169475,-0.041482214,-0.027600847,-0.025208555,-0.019163279,-0.004928826,-0.011762635,-0.03674748,-0.052550055,0.06461317,-0.036761653,-0.06527112,0.024439696,-0.038893566,0.0008063644,-0.039121658,0.028842323,-0.040983353,-0.07258707,-0.049021814,0.041863892,-0.0002961535,0.099100165,-0.0014967979,-0.068026766,0.012110399,0.0045293616,-0.027594391,0.011638893,-0.106007494,0.035426997,-0.0011886179,0.04157498,-0.07575911,0.0866349,0.0014476845,-0.099533066,-0.056602646,0.021971034,0.06431589,0.005325277,0.044409633,0.022994213,-0.004663908,-0.0050658835,0.0031846731,0.006662187,-0.028833156,-0.038989276,0.0011487794,-0.055251226,-0.040258866,-0.03009427,0.025081627,-0.00015225571,0.057865385,-0.07948159,0.1299266,0.008504619 +6.3.5.1,NH3 can act instead of glutamine (cf. EC 6.3.1.5 NAD+ synthase).,384,0.99999994,-0.035348043,-0.12809648,-0.06603762,-0.09608176,0.02161541,0.027708039,-0.02285847,-0.0041359584,0.017097687,0.008176058,-0.025419032,-0.028228832,-0.048388638,0.08329674,0.01680756,0.015589833,-0.022042248,-0.028331779,-0.023220351,-0.019044178,0.03333935,0.08944738,0.030212425,-0.017971836,0.010545633,0.03484859,0.03231442,-0.026284013,0.04812168,-0.043493878,-0.06398923,-0.031897523,0.011383676,-0.038488016,0.039056186,0.014358523,-0.11540401,0.012203607,-0.025833694,0.04025925,0.041651074,0.015245796,-0.019407647,-0.057419844,0.019025972,0.027980877,0.034228764,-0.007505621,0.04917871,0.039483104,-0.010501632,-0.06093735,0.01635807,0.004635531,0.064435355,-0.011754526,-0.17680919,0.011029396,-0.06150005,0.016576389,-0.055826742,-0.0021648954,0.008371665,-0.10977959,0.1435332,0.018777464,0.07136238,-0.045762062,-0.0039840885,-0.0008196367,-0.09396517,-0.03344497,0.019972853,0.056907102,-0.021890767,0.029560655,-0.023741128,0.0065569407,0.059517704,-0.002593136,0.024939796,0.04242529,0.026729504,0.060659904,0.012535962,0.03471611,-0.08793313,0.010790987,0.019931408,-0.02020097,-0.03975473,-0.049014125,0.048579086,0.09673929,-0.05534823,0.004422217,0.008544388,0.017393487,0.04065718,-0.014419707,0.0023343682,0.11281086,-0.10677946,-0.021574708,-0.041171093,0.07646626,0.02202939,0.1227424,-0.07755529,0.07513044,-0.033272535,0.03448875,0.047839332,-0.039651953,-0.1050277,0.043775532,0.026894772,-0.03834558,-0.070608824,0.010004755,-0.0022535615,0.011950496,0.0070836693,0.056599136,-0.04639858,0.02038787,-0.022771662,2.4143191e-36,0.046935968,0.02081962,0.026318287,-0.00031466465,0.0021176895,0.042737395,-0.080743395,-0.0037137403,0.049893867,-0.097910866,-0.07770878,-0.063675724,0.03959976,-0.017857688,-0.01879632,0.06227684,-0.046124253,-0.04754896,-0.018453013,0.0108887395,0.057657238,0.033837616,-0.021388346,-0.0042534955,-0.09781801,0.056250665,-0.0003641545,0.053797465,0.08030936,-0.0326154,0.03108533,-0.13383915,-0.067104965,0.019432513,-0.026194178,0.04492713,-0.069302805,-0.046581667,-0.039564844,0.072990134,-0.087604396,0.068346284,-0.042636164,-0.06737344,0.022934485,-0.012347222,0.0049736984,0.058977272,-0.051614508,0.061728634,0.053432595,-0.024532061,0.05248015,-0.023231136,0.008569705,-0.03346288,0.013774646,0.03243462,0.026970264,0.07987244,-0.025626104,0.017267108,0.00884133,0.04934759,-0.048770472,0.09397603,-0.11447756,-0.03847708,0.031821378,0.0675564,0.02756882,-0.005222282,0.0027072039,0.106427036,-0.009349392,-0.096484356,-0.028025236,0.014793579,0.028269188,-0.0030999307,0.04129505,-0.018793272,-0.013093851,0.069044955,-0.09011997,-0.04622449,0.013179877,-0.08878373,-0.036392894,0.029040337,0.062334705,-0.031250663,-0.010964388,-0.014796511,-0.022440346,-8.650009e-34,0.08150793,-0.03028367,-0.015320009,-0.035451155,-0.029303532,0.0676883,0.0108297765,-0.06750874,0.010705677,-0.019070625,0.065679796,0.001514002,0.034005947,0.04793852,0.0050674006,-0.047099385,-0.023976702,-0.023644138,0.0052360897,0.016295558,0.037531845,0.077594936,-0.047133368,0.05523327,0.014214589,-0.0077144657,-0.027981015,0.051148664,0.04968916,0.038679957,-0.055421837,-0.029321542,-0.056059975,-0.0600397,0.07641435,-0.0055545755,0.018323384,-0.023198755,-0.09402687,-0.06876615,-0.011617624,0.03049944,-0.0026672836,0.0695488,0.018196728,0.12808914,-0.02815131,-0.023783823,0.006088087,0.032889687,0.03169796,-0.029020071,0.0028996596,-0.051828124,0.07677693,0.01350737,0.06409468,-0.0504284,0.04827288,0.025599394,-0.01853337,-0.07647654,-0.012084048,-0.056395262,0.06661199,0.05510453,-0.011962634,0.09045639,0.09232534,0.037387714,0.017579127,-0.03980274,0.11186798,3.84844e-05,-0.016926788,-0.08136144,-0.019274868,0.009269897,0.016956253,-0.10111264,-0.0039892453,-0.013727541,0.050160114,-0.02266251,0.050798375,0.051419165,0.08393205,0.09714597,-0.0530472,0.07304036,0.0226541,0.01677468,-0.035796758,0.07162926,0.0015529979,-2.8694155e-08,0.09528769,-0.031019047,0.029227493,-0.030026123,-0.04966658,0.09085839,-0.011399142,0.01758197,0.008318616,0.039055664,0.008595421,0.079810955,0.02526847,0.0090391785,0.008317589,-0.0035651075,-0.069985904,0.004902843,-0.053980164,-0.028587587,-0.14153685,0.039368633,-0.10519388,-0.00072331,0.06112502,-0.06338299,-0.019378508,0.033441823,0.042552657,-0.08767903,-1.2925862e-05,0.025926588,0.117834695,-0.07699606,-0.1236974,-0.014381305,0.016248127,0.03461234,-0.04438155,-0.0077286954,-0.03629571,0.025280897,-0.041416217,0.014808153,0.056779113,-0.0129392035,0.0057283235,-0.03154187,-0.03558848,-0.027225936,0.016798342,-0.012063936,0.061758533,-0.031241894,-0.038207088,0.011532956,-0.09742888,-0.07171409,0.040179815,-0.06636789,0.026728293,-0.041497942,0.05428116,0.05086993 +6.3.5.2,"Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia.",384,1.0,-0.13124053,-0.05713684,-0.0596871,-0.085543655,0.014743353,0.025154306,-0.0029984803,0.025358537,0.0039718915,0.044981904,0.033987097,-0.05997456,-0.092237726,-0.019393535,-0.07397989,0.025634052,-0.1171561,-0.008907801,-0.0088640805,-0.067895636,0.083235025,0.05291931,-0.07182426,-0.039213475,0.0106503535,0.047960836,0.073109895,-0.0046986984,0.049232263,-0.05511503,-0.08649353,-0.08679044,-0.00013557897,-0.013217688,0.0315716,0.10458438,-0.04864994,0.023491874,0.079297654,0.0046945196,0.029616341,-0.015340659,-0.022865696,0.02493437,-0.022119107,0.061822437,0.079463944,0.05779643,-0.045202706,-0.0243263,0.0061263624,-0.0033622948,-0.017431138,-0.020650176,0.045425154,0.037134323,-0.08518574,-0.01595119,-0.0414143,0.034047775,-0.0014148367,-0.031646136,-0.04908917,-0.05766891,0.089529835,-0.0534748,0.07884676,-0.016978985,0.0049910336,-0.00079285615,-0.0109490575,-0.041687563,-0.037854325,-0.0037315637,-0.037511393,0.06840199,-0.00045371868,0.03583577,0.0011925314,0.031234182,0.09382174,0.020795815,0.07422772,0.02689847,0.043450594,-0.033775028,-0.05208,0.03892518,0.048687715,0.030090528,-0.008178185,-0.10252452,0.0683205,-0.04673655,-0.042405944,0.07235168,0.01027038,-0.018812547,0.009786634,-0.017463356,-0.017041199,0.048970133,-0.01562995,-0.04238397,0.0021284756,0.034078047,0.016923008,0.057720404,0.012007204,0.056975607,-0.031130474,0.11529922,0.03838644,0.043182276,-0.07654243,0.054618828,0.020567572,-0.041854978,-0.039133508,0.0072997427,0.0026738145,0.026070772,-0.07370731,0.07088623,-0.08768061,0.029320508,-0.04214391,1.9405924e-33,0.08135911,0.0024803437,-0.013807563,-0.03138289,0.04180991,0.04328141,-0.07998491,-0.05307463,-0.025034185,0.016946089,-0.0730323,-0.054625597,0.017731069,0.01083289,-0.08531637,0.10001012,-0.044318873,0.017544353,0.06110685,-0.03761385,-0.026988538,0.043805156,-0.027337149,0.00019371674,0.0014125968,0.09876957,-0.04076021,-0.0014621392,0.02845642,-0.030417932,-0.03920196,-0.08395783,-0.0529501,0.025018867,0.10304385,-0.048749886,-0.026053108,-0.045271933,0.050259538,0.023760756,-0.05412961,0.030664748,-0.0635468,0.038768858,-0.019104296,-0.018976748,-0.00356478,0.029195558,0.012417988,0.04556977,0.0180082,-0.051408995,0.033797238,0.011235622,-0.015212044,-0.042351402,-0.019987665,-0.0803346,-0.023983711,0.03260543,0.04011886,0.022343814,0.004697735,-0.0069247307,0.05115064,0.023283476,-0.11830135,-0.066118605,0.07430615,0.12691322,-0.04094218,-0.080348246,0.031561553,0.016035065,-0.013428848,-0.040809836,-0.024284203,0.02626962,-0.002604215,0.070179276,0.023170445,0.024888333,-0.050089635,0.0018633906,-0.05441925,-0.029124506,-0.007857055,-0.08712636,-0.0006013013,-0.014938464,-0.015251676,0.0025425225,-0.02750565,0.045067497,0.019394258,-3.194607e-33,0.09494279,-0.05212577,0.009491052,-0.057470176,-0.09534374,0.020762574,-0.006994211,-0.10522427,-0.047465853,0.028541246,0.016114863,-0.0072099376,0.0075187334,0.03426142,0.027627248,-0.057343125,0.03349696,0.08858405,-0.03235252,-0.073638566,0.064807445,0.06778955,-0.004374961,0.026900653,0.026264697,-0.046039235,-0.019059552,0.055818852,-0.017275909,0.029759202,-0.10484667,-0.06193829,-0.038272522,-0.02477022,0.028908335,-0.00023100055,0.034993023,0.06786405,-0.0250478,-0.031295985,0.070205405,0.06061872,0.041309368,0.10814463,0.032062467,0.086882904,-0.061768536,-0.010011357,-0.05812518,-0.051724836,0.08172848,0.049690705,-0.0262493,-0.03675566,0.04824698,-0.005693495,0.0038082462,-0.046170507,0.04217501,0.012634907,-0.030113215,-0.13107723,-0.063825846,-0.041670334,0.042830452,0.06067288,-0.011157379,0.11664154,0.02211675,0.03628159,0.0022054461,0.0008737704,0.114609376,0.031200558,-0.027734496,-0.06905094,-0.041726757,-0.114976525,0.02910013,-0.093924366,0.03255017,-0.0058571775,-0.0011293344,-0.033106565,0.0023319658,0.019231318,0.10262917,0.14416732,0.032364525,0.025667714,-0.002394492,0.017198915,-0.02164604,0.08909959,0.018646974,-3.5223e-08,0.04494623,-0.04019147,0.0020695683,0.0007069663,-0.04986002,0.0934753,-0.03406411,0.07644978,0.05628683,0.003308046,-0.008888208,0.09022688,-0.0077550327,0.042803947,0.05369331,0.06934393,-0.040864933,0.02544469,-0.0076682377,-0.03317403,-0.074432895,0.037831366,-0.13614897,0.06327058,0.007456961,-0.059350137,0.049548227,0.038128953,0.007958768,-0.014141159,0.038617525,-0.0049144337,0.044306587,-0.023847917,-0.044426996,-0.02432765,-0.028165,-0.012006616,0.021516085,-0.07812056,-0.07735911,0.08925917,-0.043096054,0.03677501,-0.058762446,0.028345048,0.03847089,0.030097732,0.00048709594,0.09701589,0.060209617,-0.013060668,0.07580148,-0.043304484,-0.09381025,-0.079489365,-0.024476191,-0.044006687,-0.012065015,-0.007425385,0.016383827,0.0101226205,0.09078328,-0.028759051 +6.3.5.4,"The enzyme from Escherichia coli has two active sites [4] that are connected by an intramolecular ammonia tunnel [5,6]. The enzyme catalyses three distinct chemical reactions: glutamine hydrolysis to yield ammonia takes place in the N-terminal domain. The C-terminal active site mediates both the synthesis of a beta-aspartyl-AMP intermediate and its subsequent reaction with ammonia. The ammonia released is channeled to the other active site to yield asparagine [6].",384,1.0,-0.015999286,-0.10710904,-0.06471825,0.00849272,-0.026768347,0.049963858,-0.008537344,0.0068879216,0.04690181,-2.0988584e-05,-0.02876726,-0.04207931,-0.037980437,0.032294564,-0.03374577,0.00921086,-0.02599769,-0.061536226,-0.019636327,-0.07548189,0.049909137,0.033238932,0.00339903,-0.06512289,0.032851957,-0.0204397,0.044703137,-0.040622685,0.04858489,-0.11218049,-0.08022438,-0.08095286,0.011268726,-0.01129148,0.11745772,0.055182606,-0.022911794,-0.033800043,0.09593346,-0.004920407,0.03354736,-0.005096693,-0.030948441,-0.03844913,-0.026535507,0.072259024,0.05642587,0.011743201,0.05393685,-0.050218113,-0.003003281,-0.02251835,0.010621811,0.047144208,-0.0034968685,0.05976704,-0.11030483,-0.06992582,-0.015045893,0.03966016,0.03772416,0.047331296,-0.004499026,-0.07536422,0.04126641,-0.07738674,0.03459119,-0.0541301,0.026431948,-0.02234038,-0.057844304,-0.07974302,-0.0013428198,-0.022354972,0.040108077,-0.08389763,-0.012310194,-0.006849987,0.02882975,-0.058247756,0.071540296,-0.016331408,0.06537806,0.040175904,-0.032141387,-0.005140909,-0.0011783334,-0.009915876,0.11949295,0.016575687,-0.07266283,-0.069603525,0.045495547,-0.04347199,0.03845392,-0.051100455,0.06414236,0.0026027525,0.05970315,-0.022867667,-0.004498012,0.0729767,-0.0454121,-0.038892943,0.032361735,0.006021705,0.0058163563,0.17128468,0.03920129,0.020981953,-0.018620785,0.020549614,0.08633444,-0.015288669,-0.06930496,-0.0050704465,0.016143834,-0.042727504,-0.049972996,-0.00025160846,0.034643088,-0.031368647,-0.0056290906,0.08431747,-0.071845375,0.04254668,-0.07008594,1.9460267e-33,0.09136201,-0.01642481,0.023036057,-0.064334735,-0.015282116,0.036492165,-0.045032606,-0.032195833,0.0145601,-0.01673261,-0.11227301,-0.080768734,0.020767193,0.015953276,-0.030990478,0.008063096,-0.046903525,0.007998833,0.019258106,0.024149012,0.0030144681,0.038342357,-0.051150087,0.034041785,-0.005194377,-0.00047689516,-0.029097231,0.024004256,0.0030621802,-0.012671347,0.033714596,-0.061451383,-0.12907703,0.04862137,0.054781675,-0.010568289,-0.014452172,-0.015382093,-0.016855527,0.0072085056,-0.059495833,0.030671401,-0.036448345,-0.021398984,0.02051939,-0.016609544,-0.014335567,0.052175228,0.040877994,0.08604704,-0.025007227,0.016036376,0.10029426,-0.05413037,0.004407403,-0.009473479,-0.011266145,0.0031590972,0.025637977,0.117850974,-0.016214062,0.031524256,-0.084574975,0.017484937,0.010926804,0.0742707,-0.03895259,-0.03549887,0.08129934,0.1173345,-0.14874427,0.051140986,0.03129396,0.034687914,-0.043826796,-0.034037318,-0.10693467,0.015010709,0.049166612,-0.021866264,0.03947262,-0.008703101,-0.021556534,0.06020654,0.00028789803,-0.018312117,-0.021274894,-0.06743709,-0.03945367,0.026789993,0.041991115,-0.069868825,-0.037489828,0.057195276,0.050166618,-3.759701e-33,0.097718455,-0.04090855,-0.006839878,-0.054943096,-0.12713028,0.02059452,0.00859279,-0.050175883,-0.03316814,0.07246846,0.04002219,0.10806399,0.04517033,0.07644411,-0.02345483,-0.028538186,0.028389955,0.07723092,0.02328077,-0.006397812,0.03629695,0.04063511,-0.025479568,0.01904514,0.024584942,-0.0054036607,0.032613624,0.012688957,-0.0058571724,0.045086253,-0.0031812126,-0.015133049,0.008287539,-0.10452613,-0.024128351,0.04609695,0.00530859,-0.029822491,-0.03911256,-0.054706745,0.043186646,0.012660522,-0.0030937213,0.090049714,-0.013323134,0.14443798,-0.080412574,0.030200332,-0.049376853,-0.05275457,-0.0027807767,-0.04042199,0.028467145,-0.08398766,-0.017384391,0.021617487,0.02854593,0.024934774,-0.012978723,0.0003257643,0.021318436,-0.049060818,0.05493307,-0.08174369,-0.015123151,-0.027865596,-0.0020397839,0.04832876,0.0013049215,0.012210461,-0.046475694,-0.018475877,0.10599631,0.037253536,0.0070893588,-0.071217634,0.015530884,-0.080358274,0.05449899,-0.01583502,-0.024956256,0.024089485,0.0056146095,-0.059028845,0.044682674,0.024199935,0.081350215,0.16408798,0.0057432847,0.034626767,0.009833003,0.017369257,-0.0058362507,0.031683996,0.052638598,-4.3562977e-08,0.08663199,-0.03420469,0.034967143,-0.095574334,-0.00074375933,0.12518564,-0.008258018,0.02196488,0.015935564,-0.020118214,-0.034207687,0.09739044,-0.020900756,-0.00090673496,-0.0073607103,0.014615799,-0.08737,-0.010939322,-0.014282739,-0.03901189,-0.082799144,-0.0043783933,-0.0755149,0.064547926,0.06985745,-0.07002807,0.046060745,0.020545397,-0.06659655,-0.024106737,0.03753519,0.027673155,0.037063528,-0.035540767,-0.10282828,-5.0165352e-05,-0.019565733,0.02174196,-0.005361909,-0.023118915,0.012027039,-0.0073141614,-0.006329947,0.015334559,-0.023779824,0.13630947,-0.020956362,0.033242583,-0.05516858,-0.023911694,0.044025026,-0.096748196,0.03157137,-0.011847847,-0.09880525,-0.008000419,-0.087164395,-0.11645141,0.01895442,0.02299766,-0.0020969915,0.06157756,0.08495645,-0.052464094 +6.3.5.5,"The product carbamoyl phosphate is an intermediate in the biosynthesis of arginine and the pyrimidine nucleotides [4]. The enzyme from Escherichia coli has three separate active sites, which are connected by a molecular tunnel that is almost 100 A in length [8]. The amidotransferase domain within the small subunit of the enzyme hydrolyses glutamine to ammonia via a thioester intermediate. The ammonia migrates through the interior of the protein, where it reacts with carboxyphosphate to produce the carbamate intermediate. The carboxyphosphate intermediate is formed by the phosphorylation of hydrogencarbonate by ATP at a site contained within the N-terminal half of the large subunit. The carbamate intermediate is transported through the interior of the protein to a second site within the C-terminal half of the large subunit, where it is phosphorylated by another ATP to yield the final product, carbamoyl phosphate [6]. cf. EC 6.3.4.16, carbamoyl-phosphate synthase (ammonia).",384,1.0,-0.022798065,-0.046453077,-0.07898623,-0.091030054,-0.037767053,0.07275131,0.0006449513,0.044134013,0.0132812755,-0.00057131436,-0.013964789,-0.044740494,-0.015860269,-0.023846671,-0.023150314,-0.021085521,-0.04068893,0.017158756,-0.0020956302,-0.05955185,0.08168038,0.05955737,-0.041351262,-0.07881261,-0.0150112435,0.025959415,0.08169271,-0.0026182989,0.026871668,-0.05061965,-0.065058805,-0.097106986,0.019649325,-0.05797679,0.11503465,0.11409095,-0.03525451,-0.026944136,0.12998831,-0.02864845,0.06240561,0.011426573,-0.04183889,0.00819818,-0.011337655,0.044533208,0.120447434,0.058212932,-0.029118706,-0.086053856,-0.061221518,-0.0044758753,-0.010397024,0.034367986,-0.025223903,0.030127266,-0.05471515,0.02021967,-0.003963401,0.015807865,-0.009254555,0.007353381,0.0029816881,-0.07713975,0.072784096,-0.09554284,0.07986138,-0.027225686,0.015845953,0.0023033023,-0.10506822,-0.018882724,-0.0055704056,0.014857456,-0.033842705,-0.044113465,-0.013800488,0.009613596,0.07542327,-0.027274812,0.058234103,-0.03189834,0.057565656,0.01951602,0.016634844,-0.07788,-0.018947147,0.06275501,0.06288176,-0.0043142657,0.0014785825,-0.087160535,0.03296924,-0.057683244,-0.018589864,-0.025150213,0.023410328,-0.019016122,0.080050394,-0.04958728,0.042457372,0.05611467,-0.021376098,-0.08307777,0.018057402,0.06428265,-0.04011994,0.15121566,0.025955487,0.055111498,-0.073274724,0.052003387,0.037691075,-0.014469805,-0.058095247,0.03771731,-0.011551075,-0.052165203,-0.02824503,0.04627464,0.012565802,-0.034555364,0.0844352,0.09583318,-0.050119087,0.025922153,-0.09210258,3.568413e-33,0.045530498,0.015606483,0.04986524,-0.0262463,0.0026656243,0.040649347,-0.08072465,-0.022519866,-0.035022702,-0.010109569,-0.068967715,-0.09101535,0.056199543,-0.005426213,-0.046887327,-0.0038913765,-0.1292145,0.01472354,0.048905473,-0.005188143,-0.03608618,0.07802748,-0.0212399,0.06556962,-0.035507344,0.0678198,-0.02479998,0.02359647,0.010193732,0.007183077,-0.0023295702,-0.1001021,-0.100892544,-0.0075110546,0.08194784,-0.084680386,-0.016398683,-0.039991483,0.022860678,0.0056703943,-0.002088356,-0.042096883,-0.013564201,-0.024522774,0.027574373,-0.067967296,0.002770568,0.08808486,0.033662666,0.079672866,0.017196286,-0.07667182,0.1069114,-0.06696881,-0.0723276,-0.0077959327,-0.03732535,-0.031812828,0.05499314,0.053178754,0.029070327,0.053953275,-0.015845329,0.0519745,0.013861503,0.049743693,-0.09127713,-0.07030294,0.088809825,0.16809885,-0.028766913,-0.017002009,0.07082859,0.05008476,-0.018829025,-0.004986487,-0.07859799,0.044777505,-0.0042270864,0.010966276,0.036741827,0.02323144,0.005425949,-0.013395811,-0.008861311,-0.063316256,-0.033869676,-0.063595094,-0.028099492,0.043238387,0.024886431,-0.08191376,-0.023044338,0.05950589,0.014067169,-3.7843755e-33,0.16718051,-0.010042121,0.047493838,-0.055811096,-0.040321574,-0.015848963,0.05860587,-0.0358162,0.0033953467,0.0131020285,0.00440601,0.002758787,0.07667072,0.043043364,-0.059817072,-0.012505749,0.047979638,0.07574575,0.009309592,-0.03984202,0.040291775,-0.015649645,0.0053999997,0.057618916,-0.016741505,-0.006318487,-0.016731089,0.047558185,-0.0047672344,0.03839602,0.0034962052,-0.06575115,-0.033536,-0.08177467,-0.09367482,0.014292669,-0.046370205,-0.01038967,0.0011926666,-0.016706126,0.07063592,0.017115388,-0.011556332,0.0010944495,-0.007152822,0.077715,-0.010574433,-0.01982244,-0.09661072,-0.066687144,0.034974616,0.010945789,0.03485824,-0.036095288,0.009739633,0.028092533,0.0045960196,0.019372655,0.009937535,0.01812105,0.0015469905,-0.08287335,0.04799326,-0.026350677,0.03767353,0.027761703,-0.021552704,0.0556635,0.033350863,0.031089732,0.01335756,0.039999306,0.07618487,0.028471984,-0.00641223,0.048145045,0.011910965,-0.08716792,0.07104938,-0.08159552,0.005181773,-0.0205786,-0.03243041,-0.03781084,-0.03568158,-0.015839411,0.02865374,0.10783218,0.032390457,0.014041857,-0.02149623,-0.0055617597,0.0117100505,0.050572574,0.059273813,-5.002087e-08,0.0677721,-0.03019957,0.030044472,-0.049505945,-0.007509803,0.12692344,0.017725728,0.022571903,0.04963049,-0.06399034,0.006462947,0.009830979,0.011700364,-0.026312238,0.026199985,0.03975547,-0.069508985,0.008245593,-0.0397238,-0.040252574,-0.056087453,0.030884067,-0.07377093,0.08395958,0.078362055,-0.051614914,0.035579816,0.030491946,-0.051007435,-0.022319436,0.015821207,0.0039120074,0.009106162,-0.055704992,-0.08902548,0.017556977,-0.037525356,0.048802327,-0.05037034,-0.036731917,0.0015327092,-0.012538066,-0.053509377,0.018528746,0.02390866,0.1169871,-0.047102433,0.046522815,-0.061302345,-0.011336997,0.038761202,-0.017402574,0.014326478,-0.06881798,-0.09032324,-0.013217624,-0.05717232,-0.06708013,-0.004023877,-0.016628016,-0.0015037577,0.10521263,0.12598504,-0.0025265897 +6.3.5.6,"This reaction forms part of a two-reaction system for producing asparaginyl-tRNA in Deinococcus radiodurans and other organisms lacking a specific enzyme for asparagine synthesis. In the first step, a non-discriminating ligase (EC 6.1.1.23, aspartate---tRNAAsn ligase) mischarges tRNAAsn with aspartate, leading to the formation of aspartyl-tRNAAsn. The aspartyl-tRNAAsn is not used in protein synthesis until the present enzyme converts it into asparaginyl-tRNAAsn (aspartyl-tRNAAsp is not a substrate for this enzyme). A glutaminase subunit (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is transferred by a 30 A tunnel to a synthase subunit, where it is ligated to the carboxy group that has been activated by phosphorylation. Bacterial GatCAB complexes also has the activity of EC 6.3.5.7 [glutaminyl-tRNA synthase (glutamine-hydrolysing)]. 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In the first step, a nondiscriminating ligase (EC 6.1.1.24, glutamate---tRNAGln ligase) mischarges tRNAGln with glutamate, forming glutamyl-tRNAGln. The glutamyl-tRNAGln is not used in protein synthesis until the present enzyme converts it into glutaminyl-tRNAGln (glutamyl-tRNAGlu is not a substrate for this enzyme). A glutaminase subunit (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is transferred by a 30 A tunnel to a synthase subunit, where it is ligated to the carboxy group that has been activated by phosphorylation. Some bacterial GatCAB complexes also has the activity of EC 6.3.5.6 [asparaginyl-tRNA synthase (glutamine-hydrolysing)]. 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In the absence of PabA and glutamine, PabB converts ammonia and chorismate into 4-amino-4-deoxychorismate (in the presence of Mg2+). PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form p-aminobenzoate.",384,0.99999994,-0.011127059,-0.06931701,-0.04737392,-0.096667886,-0.009088456,0.051130764,0.011588161,0.014551634,-0.018790802,0.022068543,0.0181945,-0.061190885,-0.015641527,-0.017042954,0.0008238701,0.024948051,-0.034814525,-0.016513553,0.014509485,-0.04676214,0.026890898,0.081248544,-0.042123955,-0.035182144,0.0047473707,0.086387776,0.06828154,-0.052876256,-0.00377648,-0.07030941,0.0626639,-0.07382854,0.026263835,-0.014386089,0.056708217,0.061368138,-0.11804871,-0.022064067,0.059812877,-0.059747744,0.032088503,0.058296114,-0.005276082,-0.051989395,-0.03532389,-0.0018434803,0.047259912,-0.02343507,0.010669683,-0.09187276,-0.014439265,-0.08880224,-0.04361593,0.055970896,0.025312133,0.069552064,-0.07136676,-0.0140638305,-0.070791654,0.022594223,-0.0754995,0.085531846,-0.0109821,-0.044353012,0.06148238,0.027109291,0.07976921,-0.094929144,0.029395886,-0.08055657,-0.075138904,-0.061951358,0.01970393,-0.026850924,-0.065087356,-0.03810551,-0.017995337,0.039309844,0.051824886,-0.012301901,0.019521449,-0.0285607,0.018276203,0.057638947,0.019890245,-0.0071542985,-0.030004177,0.017878922,0.105533615,-0.052975588,0.06387786,0.039003503,-0.014816152,0.032260016,-0.0238954,0.013267988,-0.005828093,0.08032643,0.087329514,-0.037163135,0.0766815,0.07404671,-0.049556363,-0.13176803,-0.0139854895,0.0060733706,0.112031244,0.05419403,0.013072029,0.032194033,-0.051419683,0.024214823,0.015854472,-0.022505749,-0.060827028,0.022667898,0.07444629,0.008021518,-0.027700033,0.020382717,-0.011623455,0.049567714,0.09739013,0.0554513,-0.03741231,0.05510622,-0.102206804,2.4593346e-33,0.049687997,0.0074115973,0.052274425,-0.06779871,0.005836161,0.048157282,-0.049784176,-0.01869381,-0.0010903998,-0.061789505,-0.13036327,-0.06893736,-0.024002375,0.02767809,0.01585363,0.019207224,-0.117110096,0.008050308,0.06488929,0.033328,-0.04006367,0.057581145,-0.09890428,0.116042554,0.00019837226,0.08406608,0.016237097,0.00277052,-0.04305186,0.0008914242,-0.08256581,-0.06357503,-0.12907808,-0.042261187,-0.047572,-0.0044690636,-0.0799628,0.02563365,0.0041192267,0.035150826,-0.04492506,-0.049893375,-0.019064851,0.019653907,0.03909829,0.0001979942,-0.062065814,0.08050673,-0.0059340973,0.059631035,0.023155581,-0.108304225,0.05082045,0.064625815,-0.099443205,0.025128588,0.03085495,0.0637931,0.11772194,0.055510238,0.04650481,0.060235504,-0.02817609,-0.024967838,0.050477307,0.022709986,-0.008507486,-0.06114543,-0.020196848,0.045709282,-0.06755607,-0.08279543,0.02498328,0.065989226,0.019143663,-0.101262875,-0.06835564,0.013530458,0.07337433,0.0015067236,0.012829739,-0.007988008,0.019683458,-0.045170076,-0.026432196,-0.074250534,0.0321942,-0.008538073,-0.059946038,0.0228253,0.0779151,-0.05779977,-0.0110168625,0.013038612,0.019872338,-3.2640345e-33,0.06380768,0.0023265623,-0.012035375,0.0018713927,-0.03635684,-0.021390785,0.035199326,-0.03503141,0.029673897,0.030158324,0.04505124,-0.03902727,0.049417242,-0.014451319,-0.013254245,0.021402003,-0.02997566,0.08763179,0.014481381,-0.00831847,0.05852616,0.032773346,0.0017868247,-0.011012058,0.054000687,0.00357263,0.07572142,0.09500805,0.060338542,0.034670226,-0.0054703816,0.020168185,-0.042788226,-0.05110726,-0.12326907,0.023938477,-0.0032728512,0.033132024,0.005788651,-0.012681002,-0.028120518,0.055474933,0.05466189,0.05883343,-0.023240065,0.06472684,0.0042737904,-0.07238382,-0.06574705,-0.06403885,0.055754766,0.033951126,0.018225811,-0.046122678,-0.012867752,0.008404855,-0.015161022,-0.036204897,-0.04103286,-0.03383037,-0.055839173,-0.05802432,0.05159189,0.039536383,0.007943761,0.020931592,0.06518025,0.024378872,0.026715139,0.011465806,-0.010509203,-0.0069435076,0.074649975,0.07687482,-0.005665133,0.033509467,-0.04630618,0.01495141,0.044178553,-0.13429889,0.062157944,-0.0575214,0.05187681,-0.0830462,-0.041138545,-0.11356509,0.034115713,0.10228612,0.006077506,0.038602475,-0.03584948,0.031448424,-0.028679226,0.089923896,0.05710146,-3.8635037e-08,0.016148183,-0.06429451,-0.007549934,-0.007772979,0.060387876,0.07234423,-0.0026310415,-0.006630804,0.051835716,-0.051513348,-0.0044646277,0.04082496,-0.055746276,0.045385547,-0.013595352,0.07003648,-0.053310346,0.01727465,-0.016954992,-0.02504166,-0.060029563,0.0028136545,-0.1052985,0.022904595,0.04601275,0.018493855,0.01527955,0.0906677,-0.023048913,-0.028266039,-0.02350529,0.065285765,-0.029181106,-0.09461928,-0.074513435,-0.019036096,-0.0053220163,-0.045294054,0.011555665,-0.0026237639,-0.019210128,-0.009151963,-0.07638406,-0.021968469,0.058084473,0.0027479664,0.008784532,-0.01871181,0.000685401,-0.011699008,0.070653774,0.0042181425,0.009510311,-0.045573138,-0.09353997,0.035842333,-0.046480898,-0.033775967,0.004822304,-0.07644787,-0.029053489,0.026385544,0.11484997,0.010329919 +6.3.5.9,"This enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, generates hydrogenobyrinate a,c-diamide, the substrate required by EC 6.6.1.2, cobaltochelatase, which adds cobalt to the macrocycle. The equivalent reaction in the anaerobic cobalamin biosynthesis pathway is catalysed by EC 6.3.5.11, cobyrinate a,c-diamide synthase.",384,1.0,-0.024121234,0.039050464,-0.16709907,-0.03253658,0.070430756,0.05902336,-0.061362516,0.003379967,-0.01901641,-0.0237,-0.042366553,-0.12943453,-0.04106303,-0.07367698,-0.004607887,0.026787637,-0.045801125,-0.036363985,-0.027302917,-0.0051942524,-0.02209066,-0.050032765,0.015553334,0.047469057,-0.03113853,-0.0076875393,0.07064465,-0.0025380172,-0.0071335435,-0.025611786,-0.0424214,-0.0007547718,0.09207748,-0.032135636,-0.0025583082,0.078732945,0.0062052053,-0.023009874,0.029582847,0.008065865,0.0421266,0.057606842,0.03649485,0.018030405,0.021388095,0.00032629515,0.06276596,0.0325505,-0.0100437105,-0.015929464,-0.06538266,-0.05913323,-0.07059206,0.00712716,-0.040504184,0.04423651,-0.05015871,-0.009453656,0.06899228,-0.03480647,0.03452751,-0.08148885,0.053928696,-0.0060470896,0.027316563,-0.059822805,0.033601075,-0.06889949,0.016969012,-0.06927089,-0.05183533,-0.08602752,-0.0258257,0.010096192,-0.059723478,0.09050701,0.008810586,-0.053478613,0.052515294,-0.011500667,-0.042896505,0.045374695,0.023738032,0.03129428,0.038248487,0.00028575258,0.030260788,-0.033663873,0.04102688,0.055775005,-0.013896306,0.008231869,0.041602306,-0.0079401145,-0.17175947,0.013418667,0.08181095,0.11753229,0.057328485,-0.03859735,0.040532704,0.103420325,-0.04599459,0.0010725248,-0.033184122,-0.023199562,0.06296373,0.17977595,0.032013156,0.04378787,-0.04474261,0.059411515,0.010805149,-0.011902318,-0.0017508082,0.100855075,0.060049042,-0.0158164,-0.07642465,0.10064271,0.08545133,-0.015987266,0.033324577,-0.027225008,0.006244698,-0.058456242,-0.017512605,1.7543245e-33,0.07660175,0.047767103,0.013090943,0.009967041,-0.011466431,0.021146435,-0.13818562,-0.019722877,0.015977,-0.05717185,-0.008165944,-0.022658113,0.05005213,0.04310733,-0.075856954,-0.06309061,-0.026354,-0.050413795,0.005731318,0.028060222,-0.0029164392,0.056408163,-0.028908655,0.026912168,0.030728038,0.052513182,0.039282292,0.03134809,0.013531652,0.012138469,0.0032538737,-0.06165894,-0.08203216,-0.024115086,0.050620243,-0.045398243,-0.04400329,0.015341815,-0.014966813,0.02243763,0.021553209,0.012983942,-0.07612008,-0.024482569,0.06827827,-0.084423445,0.00572158,0.12083697,0.040597294,0.02705566,-0.01245078,-0.028321955,0.107285686,0.0298897,-0.0035694188,0.022044824,-0.047678016,-0.013822499,0.023683056,0.057009406,0.071965225,0.055014413,-0.0029081993,0.107296966,-0.003977114,-0.014385331,-0.05204248,-0.040125724,0.035576165,-0.011916407,-0.024141453,-0.09714729,0.061783947,0.09118315,-0.023339462,-0.03368999,-0.057472866,-0.0903127,-0.0023156018,-0.07426342,0.00802085,-0.01411102,0.04321503,-0.03570514,-0.032906983,0.020876957,-0.07304504,-0.037070304,-0.042780988,-0.03224007,0.009843819,-0.0022244838,-0.018651966,-0.009766005,0.019870691,-2.1504405e-33,0.0961171,-0.04370037,0.033053726,-0.09480406,-0.0267888,0.045229882,0.045394827,-0.12052984,-0.011893198,-0.044721246,0.044083666,-0.031793814,0.028463257,0.006448125,-0.008543069,-0.008593475,0.013425498,0.0783896,-0.015548182,-0.020732332,-0.0036753176,-0.018731074,-0.018156555,-0.04260149,0.011810703,0.07551299,-0.015453096,0.086081415,0.099273354,0.07137748,-0.026355322,0.03816837,0.0047213715,-0.049355198,0.0027167613,0.048620768,0.0021996696,0.0019394292,-0.0013392345,0.0049018958,-0.013586146,-0.06251897,-0.055267822,0.03603466,0.051431343,0.046298157,-0.038365923,0.054696,0.019686816,0.019714227,0.036820274,-0.019087464,-0.065401755,0.027011218,0.057750013,0.016973332,0.033882644,-0.022299219,0.049228806,-0.052467458,-0.033613496,0.0549026,0.042450953,-0.040658135,-0.00428287,0.034279846,0.017069964,0.059422176,0.053332243,0.06777446,0.08315908,0.103089765,0.009920434,-0.011390456,-0.072857656,0.027274517,-0.0008213582,-0.039669495,-0.02121684,-0.039011866,-0.061619848,-0.01578645,0.10359822,-0.007248202,-0.059315637,-0.06719398,0.03476179,-0.014811175,-0.06904287,0.07811336,-0.021285854,-0.087798074,-0.03892103,0.055904772,0.017443957,-3.4631608e-08,0.032970794,-0.08699637,0.053310245,-0.013592556,0.029560583,0.104579456,-0.05872755,-0.09484805,0.059772637,-0.027261864,0.03454523,0.030771704,0.10188058,-0.011216221,-0.024917064,-0.011377262,0.008122615,0.0339748,-0.024972115,0.02823251,-0.061188597,-0.0201605,-0.04120024,-0.0039174287,0.06530858,-0.10241224,-0.055787317,0.06018197,-0.044027273,-0.024559578,-0.001459621,0.022793787,0.1098766,-0.027846804,-0.038988173,0.016256154,-0.019117352,-0.042501632,-0.04950215,-0.07443961,-0.012371493,-0.029092196,-0.10431816,0.0063251317,0.041101992,-0.019511277,-0.040693063,0.030798757,-0.0846551,-0.025042366,0.034861874,-0.042019635,0.028128037,-0.017294306,-0.004241378,0.080682084,-0.039878383,-0.08324789,-0.023954038,-0.01726101,-0.058125705,0.020511352,0.07628772,-0.14058901 +6.3.5.10,"Requires Mg2+. NH3 can act instead of glutamine. This enzyme catalyses the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates.",384,1.0,-0.026064763,-0.09050517,-0.07679421,-0.13453177,0.005364185,-0.03360933,-0.028102,-0.049245097,-0.008409744,0.031062296,0.0033210013,-0.04415269,-0.04506921,-0.0025663883,0.017981384,-0.016655887,-0.018991906,-0.02347156,0.015175145,-0.027177038,0.027833464,0.047381945,0.009154796,-0.032307066,-0.045376673,0.09567393,0.12603013,-0.0471954,0.050264638,-0.010184499,0.017586863,-0.039087612,0.03674589,-0.063057326,0.022883538,0.087591864,-0.03604891,0.005216363,0.048574954,0.0686722,-0.034915246,0.04882517,0.06960469,-0.050816223,0.04269578,-0.048661344,0.045334958,-0.0019321416,0.059489235,-0.011658675,-0.020233937,-0.01765421,-0.03753285,-0.00746904,-0.011673306,0.019543508,-0.16343987,0.050317924,-0.023690501,0.056805074,-0.056777522,-0.009144593,0.020368855,-0.09717619,0.08557541,0.007785912,0.025047377,-0.08553273,0.056624837,0.020941269,-0.03126969,-0.034877133,0.032583088,-0.03357359,-0.09335495,0.006394002,0.002089988,0.022739718,0.06765843,0.0070919213,0.0207824,0.014574872,0.09133237,0.07181101,0.04593361,0.033378694,-0.040065303,-0.0010817689,0.085951634,-0.0111517,0.047078993,0.0013458838,0.010309913,0.037816506,-0.017452573,-0.004297983,-0.029303616,0.0030161887,-0.014540004,0.022457922,-0.014441175,0.1166316,-0.08904502,-0.017669527,-0.062471088,0.05944626,0.07261002,0.10313092,-0.009751452,0.10566769,-0.018728266,0.02977501,0.032642744,-0.015198055,-0.06436504,0.056971747,0.03819017,-0.08376215,-0.013170901,-0.07977117,0.019501546,-0.0040235887,0.026152384,0.057987034,-0.021395236,0.05542775,0.006666037,7.1293975e-33,0.046793967,0.07654396,0.056789406,-0.050140098,-0.087373644,0.029314592,-0.08472435,-0.007428174,0.040075976,-0.106360294,-0.06398617,-0.040793348,0.010123005,-0.012182138,-0.050152745,-0.02233614,-0.021653632,-0.0013957643,0.03321237,-0.009200817,0.025547918,0.07136471,0.02695061,0.027137032,-0.058418103,0.100833975,0.021649454,0.025996823,0.076454505,-0.024482658,0.008888919,-0.078255944,-0.06828382,0.019283284,-0.025444359,0.063364744,-0.11848314,-0.033611514,-0.009402569,0.07618604,-0.11430034,0.0069091776,-0.026998248,-0.011535144,0.0061451057,-0.011209719,0.024811665,0.074783824,-0.05187103,0.04541901,0.027100693,0.023382872,-0.017656438,0.06861401,-0.11033047,-0.015012763,-0.022717476,-0.04744491,0.06447358,0.021633206,0.007695746,-0.045597468,0.03684588,0.036017388,0.020518797,0.042759646,-0.057430524,-0.02109319,0.05701253,0.06393125,0.0074488074,-0.05379985,0.028360942,0.10872556,-0.0021305275,-0.057730023,0.008733874,-0.016729198,0.021011492,-0.047457997,0.035881482,-0.04954967,0.072631754,0.06382184,0.0036004623,-0.03032593,-0.03601981,-0.036562875,-0.01382178,-0.0016586194,-0.044429112,-0.01221672,0.029227622,0.04612229,0.017133677,-6.51337e-33,0.09381505,-0.056324564,-0.021603204,-0.03454806,-0.11388901,-0.008582279,-0.0014605894,-0.17350057,-0.0085368445,0.010929917,0.023111835,-0.04272677,0.06318913,-0.008784389,-0.0142147485,-0.015993102,-0.0036605662,0.045366656,-0.031631824,-0.03818417,0.09852886,0.0031553898,-0.012767646,0.0018433103,0.028376311,0.050990652,0.063077055,-0.008933134,0.05473198,0.0700436,-0.033055674,0.008803191,-0.0036610805,-0.07545989,0.019699179,0.079471715,0.015392875,-0.009242903,-0.06767384,-0.007950528,0.019844975,0.041045092,0.04388289,0.04297127,-0.00898225,0.009113621,-0.060606856,0.062318116,-0.07531362,-0.030230783,0.0040332223,-0.0044144494,-0.010186026,-0.083328545,0.059479773,0.047574315,0.011959411,-0.04805958,0.015440734,-0.014047646,-0.043785445,-0.05638652,-0.012393681,-0.046973336,0.071004316,-0.01966863,-0.013927229,0.07401238,0.021935996,0.04267473,-0.03427221,-0.026705066,0.15039894,0.07149217,0.004980676,-0.034994807,-0.0126729105,-0.07690468,0.06614608,-0.1420724,0.024087323,-0.04789691,0.106795326,-0.0015471525,-0.019264862,0.021343227,0.050768707,0.051060326,-0.035784934,0.03774146,0.030775994,-0.011939959,0.034489974,0.09416902,0.0017301742,-3.9923126e-08,0.034468763,-0.036547624,0.015526874,-0.020319339,-0.0327534,0.12622139,-0.048125826,-0.042298943,0.0101607675,-0.07324147,0.0009012485,0.024049008,-0.0075983494,0.013998625,-0.075020306,0.016783562,-0.059059653,-0.015102296,-0.06580716,-0.03871183,-0.13272823,-0.025900664,-0.10377605,0.00084918726,0.05591176,-0.026466595,0.009881754,0.12027555,-0.0013343976,-0.003562877,-0.013066356,-0.0036137465,0.05752845,-0.0904631,-0.05504901,0.036047265,0.03742672,0.010880586,-0.008045896,-0.1045189,-0.08042742,0.05301441,0.0025396938,0.002714512,0.04682164,-0.016209284,-0.0021417867,0.015648706,-0.040438537,0.07803409,0.011413916,-0.040778704,0.0726694,-0.016100653,-0.019615626,-0.06124347,-0.09377526,-0.03959025,0.024756895,-0.054057565,-0.0073843235,-0.0042995866,0.051161192,0.010007426 +6.4.1.1,A biotinyl-protein containing manganese (animal tissues) or zinc (yeast). The animal enzyme requires acetyl-CoA.,384,1.0,-0.12239809,-0.043921497,-0.024929082,0.06858772,0.08479165,0.03510828,-0.02093959,0.033738077,-0.031022323,-0.0095878765,0.071597956,-0.0666736,-0.03001026,0.045556705,-0.06416213,-0.0139109,-0.06131918,0.007943468,0.012122144,-0.013094993,0.07331804,0.075309396,0.0037742762,-0.04331777,0.03679887,-0.04564902,0.005000878,-0.04731194,-0.008623333,-0.03319325,-0.04595364,0.016572231,0.09173694,-0.022019736,0.017809996,0.041711096,0.046884645,-0.050808728,0.010032449,0.009600523,0.037852768,0.019133046,0.01373402,-0.017772544,-0.0069539845,-0.053038325,0.046761673,-0.11091897,0.063782096,0.06394633,-0.09053127,-0.029374287,0.0006696221,0.028427325,-0.016260631,-0.034698494,-0.060732037,-0.05804085,-0.024004932,-0.037266947,0.025415458,-0.049543146,-0.02150841,0.008213728,0.034823667,-0.063464314,-0.029220056,0.028753208,0.0351632,-0.009953261,0.018477852,-0.06429169,-0.050085954,0.0952735,-0.06597132,0.047717974,0.073281355,-0.061345108,0.07297668,0.023638828,-0.046965655,0.06160465,0.0325876,0.059378296,0.09422093,0.07534616,0.00730957,0.07204642,-0.09752372,0.03052373,-0.0074578794,-0.008727163,-8.27489e-05,-0.005538207,-0.04446608,0.03987833,0.01896229,0.0025979273,0.008891098,0.029722461,0.026234204,0.054603536,0.051588777,-0.06361374,0.02085177,0.004162293,-0.02110883,0.09688426,0.03148119,0.041532904,-0.003676434,-0.021515325,-0.03138597,0.0011635438,0.036416996,0.06143319,0.027764218,-0.037393622,-0.01891709,-0.005358789,0.017888905,0.043785997,-0.0062141377,0.03042533,0.030313874,0.05426264,-0.04471266,-2.1456686e-33,0.067261375,-0.0063066054,-0.018147843,-0.0055572675,0.0006597334,-0.007323658,-0.05448909,-0.000989941,0.04376944,-0.040249947,-0.063410364,-0.01950938,0.0077360747,0.03872901,0.011889371,-0.05597773,-0.02123904,-0.08375851,0.14349085,0.02299502,-0.047402333,0.05287085,-0.04262159,0.020992916,0.02535636,-0.05415909,-0.016743887,-0.040605973,0.024850793,-0.009613839,0.0010902798,-0.096964136,-0.013224275,-0.014254806,0.051910162,-0.044138905,0.008180828,-0.085539326,-0.030864436,0.025125423,0.07683151,-0.01893301,-0.049617287,0.05056287,0.050700326,-0.06534763,-0.106452666,0.061539322,-0.015630556,0.036636405,0.03292935,0.044705115,0.11308214,-0.058096845,-0.077300645,0.056879107,-0.02471629,0.021582292,-0.019848047,0.080708414,-0.03833296,0.014116789,0.005889066,0.14257021,0.07107945,0.003457623,-0.102905385,-0.08640945,-0.0378741,0.035887156,-0.06529702,-0.12087813,0.06672553,-0.037309133,-0.018173335,-0.05363024,-0.054517638,0.004442263,0.015793458,0.011534314,-0.046701886,-0.024894873,-0.045688737,-0.020094367,-0.07968426,0.049055383,0.05199456,-0.0429703,0.06405319,-0.0864431,0.07734871,-0.010043306,-0.04233554,0.016203824,0.0011020834,-7.9471293e-35,0.056000218,-0.062049374,0.071398,-0.037513796,-0.0793498,0.061488897,0.03716626,-0.07906549,0.00630209,-0.018351667,0.09190465,-0.059363626,0.015372026,-0.036206786,0.024184935,0.0603936,-0.06142261,0.047035307,0.07291884,0.03348882,-0.05288479,0.033274963,0.054464266,0.080864936,0.050326146,0.04247421,-0.05824474,0.008565925,-0.019974444,-0.014334351,-0.025577134,-0.014140553,0.013594413,-0.135283,-0.03873943,0.007441134,-0.01844045,-0.017129155,-0.037965424,0.0029610142,0.021160876,0.0038345812,-0.041142605,0.08075473,0.000110554145,0.021547189,-0.054365676,-0.00026337372,-0.035180453,-0.033181816,0.028665014,0.042457856,-0.03125208,-0.062103834,0.0029981518,0.025397606,-0.022469994,0.018100837,0.079772025,-0.010069552,0.023414023,-0.034001853,0.0044891573,0.04654748,0.027773872,0.06914444,0.021810407,0.003382286,-0.0012339009,-0.028679458,0.07291205,0.11972133,0.13442227,0.06250729,0.052146025,-0.02415342,-0.04104866,-0.037862882,-0.05966065,-0.034415606,-0.0027413003,0.014774541,-0.04791405,-0.019454882,-0.05289453,-0.038852602,-0.017225511,0.083039835,0.0067572263,0.0066093914,-0.04089195,-0.05108951,-0.080189414,0.06050503,-0.020565892,-2.3940533e-08,0.04109356,-0.07898342,0.017878035,-0.123566665,-0.034113828,0.010516486,0.03381339,-0.058136545,0.051536705,0.03653523,0.0075851437,0.107559174,-0.030597344,0.036426287,0.0011282557,0.014550615,0.026573278,0.053757176,0.002429131,0.0029190816,-0.039334897,0.03946741,-0.055447765,0.095020205,0.011094214,-0.027987197,-0.013484056,0.1499437,0.001593935,-0.052472003,-0.015624663,0.017561734,0.022259079,-0.039617606,-0.050843358,0.0890918,0.0031969298,-0.09404494,-0.051114727,0.028261308,-0.06059885,0.042352635,-0.025763597,-0.026696421,0.008973101,-0.09110193,0.02148706,0.1006535,0.054216392,-0.061635647,-0.034471978,-0.03603908,-0.066862024,-0.10661112,-0.073296286,0.008999979,0.020485844,-0.1046704,-0.0265736,-0.0063639693,-0.025042009,-0.0076867105,0.163037,-0.06706798 +6.4.1.2,"This enzyme is a multi-domain polypeptide that catalyses three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyses the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA. In some organisms these activities are catalysed by separate enzymes (see EC 6.3.4.14, biotin carboxylase, and EC 2.1.3.15, acetyl-CoA carboxytransferase). The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.",384,0.99999994,-0.08397853,-0.03446593,-0.01754416,0.0010161806,0.024461826,0.080082215,-0.05633176,0.05067721,0.056692023,-0.081497364,-0.047007572,-0.089701176,-0.094920225,-0.007250312,-0.06443678,-0.018309558,-0.066904925,0.03947545,0.021394748,-0.015253905,0.07755856,-0.0012440977,-0.020010168,0.045187373,-0.0072985054,0.00036692875,0.016964462,-0.012945205,-0.004205339,-0.057675537,-0.011232739,-0.017063605,0.0100805,0.048676565,0.0032250124,0.11716745,-0.019291392,-0.07165393,0.05797775,-0.0057057654,0.03854934,-0.045715615,-0.046353232,-0.024208304,0.0112619465,-0.080749795,-0.05845344,-0.072831705,0.043191977,-0.07782214,-0.029000614,0.023168877,-0.08430989,0.039519973,-0.0035747427,-0.00675512,-0.01068784,-0.0074022175,0.0397564,-0.01971342,0.03963382,0.0147652505,-0.0033535121,0.004338253,0.05124589,-0.101318665,-0.0059626987,-0.005023319,0.028781837,-0.03027087,-0.08105006,-0.0488036,-0.06512397,0.0732041,0.042632237,-0.0083181895,-0.07063889,-0.0223049,-0.011130071,0.016191252,0.03218553,0.031679966,-0.018339457,0.0593058,0.0072072293,-0.023390546,-0.00042336938,0.024133064,-0.033529144,0.051491573,0.047190942,-0.006356632,0.06608164,-0.026171481,-0.057318583,0.004431621,-0.015112729,-0.034697875,0.029001119,-0.014991951,-0.036922425,0.065479256,-0.032614406,-0.08294633,-0.02956484,0.0038337451,-0.007861016,0.09903956,0.1385102,-0.022417314,-0.037341334,-0.008505242,0.02218218,-0.020384664,-0.047977876,0.121951066,-0.10066645,-0.049930975,0.07234921,0.05597517,0.0021345504,-0.09397928,0.06866975,0.022618756,-0.005318192,0.010405211,-0.06858633,2.9811925e-33,0.09892665,-0.017571582,0.038716204,0.055781826,-0.020943109,0.0061538573,-0.0592567,0.0029009231,-0.027555292,-0.012030825,-0.026897669,-0.05399258,0.034903865,0.01571777,0.030620918,-0.049151994,-0.11188991,-0.032857597,0.10227194,0.0447694,0.024546737,0.08343101,-0.03459086,0.052409325,0.06942223,-0.034448262,-0.06330726,0.06239747,0.03063737,0.024972191,0.005424961,-0.016858429,-0.059199847,0.041125868,0.042963143,-0.020858448,0.018765526,-0.06807578,0.052305035,0.087864324,0.048855793,-0.0594293,-0.014215173,-0.056337718,0.06649953,-0.0319427,-0.057794683,0.06657733,0.0008762279,0.08112633,0.055471,-0.043432117,0.071451835,-0.02734249,-0.039143316,0.060031638,-0.11028261,-0.015816174,0.0016003893,0.072740056,0.072845116,0.049541663,-0.028700242,-0.012506685,0.014855877,0.03822451,-0.080039,-0.0054285754,-0.032670625,0.065065004,-0.01569471,0.008334899,0.06392159,-0.0051478934,0.07934084,-0.0071228547,-0.1068264,0.053766098,0.014765765,0.03498955,-0.044896673,0.02708673,0.0073583974,-0.01906323,-0.052292056,0.02613311,-0.012475363,-0.010887869,-0.0486739,0.005408322,0.025304059,-0.08613503,0.0032196061,0.07206132,-0.052958325,-5.2147898e-33,0.12464245,-0.10660683,0.0415102,-0.124675736,-0.058485437,0.03646584,0.08790919,-0.0698386,0.012344759,0.048329357,0.046749957,0.008750821,0.040081065,0.0031852787,0.019305605,-0.011323727,-0.089658074,-0.039520588,-0.07160518,0.0146990195,-0.03477537,0.029541496,0.009573601,0.08185413,0.015848259,0.016025305,-0.08019527,0.08129217,0.08108001,0.015630513,0.0059960866,-0.0061303247,-0.027761264,0.0012324242,-0.08677332,0.06367911,-0.0563589,0.0106923925,0.0046261516,0.0012482821,-0.051623534,-0.0036107076,-0.06531478,-0.004464357,0.12057947,0.035016827,-0.047506977,0.00769055,0.052232478,-0.012344249,0.022855867,0.065798216,-0.018797975,-0.015977068,-0.059821047,0.09499912,0.030158542,-9.251744e-05,0.06987841,-0.051969793,-0.004238516,-0.025256455,0.049558904,0.009403942,0.0057468168,0.099120796,-0.044403873,0.03995898,0.06953431,-0.05583657,0.045505915,0.014001811,0.094569296,0.013917326,0.0028338183,-0.024876244,-0.028090242,-0.08578495,-0.038942195,-0.02865021,-0.048039928,-0.0018883038,-0.030268667,-0.06380336,-0.11032407,-0.049171172,0.040791802,0.0075840065,-0.022701975,0.008504664,-0.0504343,-0.0024359403,0.03276651,0.041935388,-0.006832962,-4.8084868e-08,0.06414713,-0.037901953,0.051917203,-0.04736164,0.010406509,0.021039344,-0.028748672,-0.03947874,0.056812353,-0.042547867,-0.076222,0.07708119,-0.07172036,0.07201995,0.03549509,0.004255128,-0.026197419,0.018781865,0.010248228,-0.046332765,-0.09250737,-0.0012279545,-0.032676112,0.08109486,-0.027399624,-0.08020279,0.061369725,0.08207246,0.015674254,0.017553704,-0.011619615,0.053341724,-0.00010538085,0.040209122,-0.019502359,0.005727721,-0.08492862,-0.034909923,-0.022022532,0.06825586,0.05675751,-0.047683455,-0.04299119,-0.004553886,0.08816392,-0.011756569,0.014202317,0.044409543,0.041305725,-0.027444853,0.053776097,-0.015761243,-0.10022941,-0.00659976,0.0020501479,-0.006034347,-0.041861173,-0.09671473,0.048744373,-0.04374712,-0.046764515,0.029173406,0.194131,-0.01682841 +6.4.1.3,A biotinyl-protein. Also carboxylates butanoyl-CoA and catalyses transcarboxylation.,384,0.99999994,-0.06356789,-0.017299728,-0.047502995,0.051701404,0.048556868,0.08962671,-0.08596267,-0.00066912244,-0.013540932,-0.016146721,-0.0025221168,-0.05323166,-0.14082634,0.025202846,-0.06941188,0.053917237,-0.05897743,0.12022817,0.052904014,-0.015007279,0.02303162,0.015580289,-0.009305303,0.06958849,0.053182885,-0.0076504955,0.017006218,-0.010863194,0.013591612,-0.08982144,-0.047865037,-0.054954156,-0.017807834,0.009035419,0.037423328,0.041711535,-0.031611226,-0.111568876,0.046986915,-0.06275596,0.0033241946,-0.027572231,0.006731762,-0.0491346,-0.011250561,-0.08431215,0.020274978,-0.017811023,0.079447836,-0.045632314,-0.02383868,0.03705263,-0.044739474,0.011911361,0.0470127,0.00049744797,-0.017474692,-0.028019555,-1.187102e-05,-0.0038787462,0.06605554,0.010769946,0.0038103203,-0.007264267,-0.022980588,-0.068824254,-0.0662392,0.06996624,0.049487896,0.0041622273,-0.020756925,-0.07145262,0.031880006,0.041794028,0.02825194,-0.015646597,-0.0012505786,0.009446092,0.061193433,0.05609738,0.034394767,0.03453296,0.00554509,0.06615496,0.022902057,-0.029571418,0.014034377,0.11813627,-0.0526561,-0.046555705,0.017489456,-0.0314367,0.07586702,0.0018855481,-0.036139466,-0.010872003,0.035362422,-0.03537648,0.05540024,-0.044604816,-0.020816086,0.039876666,0.027960625,-0.1098121,-0.019304136,0.0024726556,-0.06390986,0.09068162,0.08483504,0.01744314,-0.012536993,0.007202469,0.029931193,0.02549876,-0.045797884,0.07087272,-0.055554133,-0.065053485,-0.028959997,0.08806575,0.018885765,0.009184505,0.01839589,0.11131384,-0.026210254,0.0008543708,-0.062935576,-2.6847735e-34,0.08755154,-0.02465999,0.02056133,0.10581317,0.017142061,-0.013908773,-0.0655465,0.008647508,-0.027433148,-0.036581904,-0.060570303,-0.03557904,0.03073066,0.030189043,0.011305188,-0.097108975,-0.07678563,-0.061548248,0.089792766,0.0072188955,-0.0844765,0.097315274,-0.06923384,0.082116105,0.053694542,-0.02101242,-0.06368539,-0.0018363529,0.04949562,-0.023333399,-0.050186206,-0.09768786,-0.03626997,0.0129521405,0.062048666,-0.042337827,0.010530859,-0.11351731,-0.021211483,0.104716554,0.08413573,-0.021196486,-0.062049907,-0.09079064,0.061262485,-0.018352725,0.012601892,0.039628036,-0.0064931675,0.06128167,0.020468717,-0.02058415,0.023146333,-0.052262455,-0.06605494,0.038802195,-0.10444691,0.013495079,0.029712632,0.031166604,-0.0132059045,-0.04411584,0.009088076,-0.030472709,0.017510118,0.009209418,-0.13357593,0.02064498,-0.031472895,0.076079674,-0.028190902,-0.029820155,0.09395157,-0.010316054,0.053946562,0.0182152,-0.094429374,0.0368529,0.028209109,0.011365529,-0.01581897,0.035848852,-0.054338947,-0.03438019,0.008010294,0.043504395,-0.025833923,-0.042825114,0.0048194397,0.056691233,-0.05561607,-0.08888359,-0.046999503,0.039282896,-0.02594325,-2.967861e-33,0.10946349,-0.1633068,0.024184788,-0.009439372,0.008135099,0.019870726,0.05092707,-0.057617817,0.018258244,0.006313525,0.055730868,-0.073403716,0.0511963,-0.041988842,0.039370324,0.06765955,-0.011685406,0.027444324,-0.0029014484,0.018656164,-0.03991141,0.02387244,-0.041004397,0.031539265,-0.019269573,0.04381858,-0.058291536,-0.011215384,0.06930738,0.06576421,0.03380583,-0.02034485,-0.046625786,-0.031630825,-0.029999234,0.059137408,-0.023235312,-0.0253567,-0.020837435,0.023423854,-0.026864618,0.0044002635,-0.04803307,0.02238028,0.09650555,-0.052463688,-0.08059235,-0.02477911,-0.015445711,-0.049397793,0.053679142,0.0066899667,-0.008938207,-0.04004173,-0.09790057,0.06284232,0.020969067,-0.013706391,0.093374446,-0.009320499,0.012290144,-0.09403309,0.030948462,-0.037871934,-0.043557446,0.06895654,-0.061398186,-0.026015248,0.024234403,-0.075217925,0.089822814,0.021212475,0.108110376,0.108895525,0.02955357,-0.026851583,-0.031005178,-0.08574365,0.007744313,-0.03188061,-0.06765325,-0.041098263,0.007937628,-0.017730322,-0.00765446,0.032942608,0.013291759,0.043981764,-0.019425562,0.02160222,0.0051199775,0.0036707674,0.0037602035,0.07904566,0.015503415,-2.6875554e-08,0.07944904,-0.066460565,0.030718425,-0.063036636,-0.034595884,0.11023989,0.07377391,-0.0260384,-0.017693419,-0.043901257,0.027055351,0.031556778,-0.061868787,0.045791652,0.022501715,0.018205281,-0.013747247,-0.03302075,0.0032756366,0.025631951,-0.0858624,0.035578083,-0.020969516,0.06084159,-0.059910055,-0.020752737,0.05476722,0.07764552,0.037450626,-0.031343672,0.008879368,0.03161229,0.036669776,0.009774973,0.017109858,-0.027514642,0.034667786,-0.047482345,-0.079248086,0.061549462,0.043625213,-0.031615265,-0.015809199,-0.03150797,0.017934725,-0.008185431,-0.0045744255,0.10768834,-0.015110592,0.007624017,0.07510902,-0.009137753,-0.09079383,-0.022530753,-0.007636137,-0.03884635,0.0050354046,-0.024535581,-0.03802565,-0.046097305,-0.06172188,0.0022702538,0.18901005,-0.050283257 +6.4.1.4,A biotinyl-protein.,384,0.99999994,-0.09147129,-0.033549413,-0.040410016,0.032101918,0.010917622,0.05967406,0.025512008,0.08391704,0.047432046,-0.010143315,0.031000528,-0.030031258,-0.10525041,0.058653757,-0.0650445,0.009621995,-0.10228493,0.03506937,0.0012735309,-0.06893653,-0.0023047868,0.08106038,0.021522213,0.046583332,-0.030682893,-0.013784414,0.0004385978,0.024183275,0.007240183,-0.07692517,0.01598021,-0.028198596,-0.019575655,0.0107196225,0.042207964,0.039166488,-0.039661944,-0.06517876,0.05104926,-0.018759718,0.06713548,-0.05227416,-0.0393369,-0.014963345,-0.007282203,-0.06659183,-0.02824774,0.0066378904,0.14500985,0.04785875,-0.089563906,-0.06768391,-0.022653002,-0.010415872,0.11859684,0.016321316,-0.0145275835,-0.049579993,0.003912414,-0.04006469,0.07203163,-0.008640392,-0.020587206,0.033095893,-8.328979e-05,-0.11644074,-0.015491889,-0.031793896,0.060584445,0.028573854,0.0058647706,-0.05902648,0.014373296,0.05077944,-0.0054172236,0.013913974,-0.0376644,-0.009832181,-0.0030407787,0.050456792,0.06449884,-0.017597977,0.035394553,0.13836303,0.04125575,-0.08330135,0.065188445,0.04239161,-0.09958729,-0.00013995821,0.0071030464,-0.029191678,0.026827391,0.006785531,-0.039489053,-0.033015087,0.0035564401,-0.067880325,-0.015205076,0.013029322,-0.036309004,-0.0039309463,0.049353853,-0.08381036,-0.03572252,-0.025451826,-0.049770847,0.07672153,0.055861738,-0.03984692,-0.0122086955,0.010907792,0.023896001,0.029741174,-0.013153394,0.063903116,-0.015476744,-0.037255425,0.01184748,0.01677519,0.0013138216,0.03963068,0.00762838,0.087205805,-0.021795062,-0.015637333,-0.0988821,-6.863266e-33,0.09619332,-0.039248846,0.019261938,0.07573053,-0.009636371,0.0012438357,-0.104770936,-0.038996793,0.0063579786,-0.062128432,-0.050078273,-0.046789166,0.022989647,0.04680708,0.028341405,-0.019938376,-0.05991303,-0.049378358,0.082474746,-0.019368056,-0.028843999,0.12379896,-0.04206624,0.019810874,0.021553047,-0.053047996,-0.03352088,-0.01690552,0.028635474,-0.0023316753,-0.036748465,-0.06732782,-0.022111863,0.010707179,0.038810458,-0.040824857,0.019836223,-0.11081021,0.018522143,0.10631724,0.039915804,-0.0009907958,-0.011831954,-0.08562099,0.074013256,-0.0114288535,-0.033444054,0.05956349,-0.014411707,0.08174201,0.06609296,-0.061652075,0.036138233,-0.0201033,-0.15033634,0.03290585,-0.070244975,0.019379623,-0.0037262088,0.023088297,0.051462185,-0.037678547,-0.038831662,0.013236931,0.05891276,0.04447586,-0.0702715,0.0012174287,-0.0031135886,0.0544731,-0.061340906,-0.032447245,0.1168825,-0.058865648,0.0026901537,-0.020650988,-0.12955536,0.030764496,-0.06832884,0.054183096,-0.055516653,-0.0006778016,-0.0652928,-0.019649953,-0.026202213,0.042175714,0.05229451,-0.01947903,0.059382264,-0.03388274,-0.011190508,-0.07831346,-0.07372975,0.01559773,-0.07168284,1.9012363e-33,0.05147833,-0.11916924,0.04883849,0.066128,-0.0066180634,0.02327731,0.022530902,0.051702935,-0.051744137,0.0031688462,0.09918729,-0.045323357,0.07993837,-0.064448416,0.038158238,0.095711,-0.09196891,0.0153056225,0.013382625,0.03527864,-0.06007051,-0.048079018,0.010547462,0.060365215,0.009498721,0.052599534,-0.011140096,0.0043924246,-0.016958233,-0.0021479777,-0.021044439,0.019953996,-0.08938189,-0.091459334,-0.004773648,0.038502097,-0.003838727,-0.037697535,5.9841004e-05,-0.0084986305,0.033003647,0.041360445,0.0054550334,0.094963506,0.12064409,0.0039768745,-0.028864948,-0.016810488,-0.07083544,-0.008697205,0.026885042,0.033274967,0.071728215,-0.033101637,-0.050100964,0.020981627,0.0066200546,0.062635094,0.06413146,0.058002196,0.04915459,-0.08204653,0.05020145,0.09559805,-0.0007369463,0.07316676,-0.05524115,0.023820193,0.011616341,-0.027161626,0.0837085,0.028273493,0.11084478,0.080332,0.035780445,-0.019467961,-0.088197075,-0.013595809,-0.020766143,0.039543167,-0.08842471,-0.0055072997,-0.05634157,-0.096040756,0.014324523,0.017963916,0.010554584,0.0524742,-0.011879442,-5.8209702e-05,0.00785221,0.011036622,-0.07268566,0.014831513,-0.004900384,-1.804371e-08,0.10839082,-0.08382242,0.032040466,-0.05869415,-0.019515313,0.037320096,0.04065268,-0.019575205,-0.023415152,0.013384634,0.03897079,0.030165821,-0.09420785,0.07050393,-0.027217936,0.05747952,-0.047057144,-0.029044872,0.017659921,-0.0069662686,-0.09151773,-0.0092138285,-0.048363045,0.048077885,-0.0008455426,-0.027584566,0.0015144489,0.0909491,0.0007861128,-0.07150041,0.05121311,0.0493773,0.0061538173,-0.03513494,-0.030038703,0.0024828936,-0.008849254,-0.047061514,-0.028624712,0.015289342,0.015888376,0.0031159539,-0.012902914,-0.045172293,0.046709802,-0.029619625,0.040196866,0.0860746,-0.00564208,0.009258513,0.021342728,0.028794019,-0.029421436,-0.028815145,-0.06606985,0.0030371952,-0.0038251355,-0.07315855,-0.049051385,-0.05463933,-0.072132684,-0.067642085,0.12461736,0.007030615 +6.4.1.5,A biotinyl-protein. Also carboxylates dimethylpropenoyl-CoA and farnesoyl-CoA.,384,1.0,-0.08080384,-0.035949636,-0.0488945,-0.01256264,0.050019186,0.08638189,-0.09071261,0.068622984,0.06877081,-0.069772944,0.0013238102,-0.075348884,-0.12701046,0.048090015,-0.041453328,-0.0079523055,-0.08703288,0.085941866,0.0116678225,-0.024774702,-0.012013108,0.066017605,0.030104974,0.076797836,-0.0070297867,-0.020061905,0.03936582,0.020089043,0.032640688,-0.068882756,-0.0005937284,0.0126256095,0.018459473,0.0060335826,0.051133104,0.058860403,-0.004310578,-0.09490897,0.030454773,-0.011557126,0.04839657,-0.051978923,0.018416822,0.022906091,-0.009935365,-0.065327965,-0.039615925,0.004820297,0.07991432,0.012319068,-0.047015328,-0.024431685,-0.05944754,0.035217278,0.06470412,0.030079622,0.0033921448,-0.022783367,0.0043378123,0.011874258,0.06358821,-0.026712112,0.014790704,-0.035994213,-0.045770925,-0.039756164,-0.024197323,0.00833548,0.051473495,-0.028531699,-0.04624775,-0.04889033,0.028696656,0.07015343,-0.017860519,-0.00041640818,-0.035108365,0.007101357,0.0403979,0.0043439446,0.0036449246,0.02199746,0.05675334,0.10033631,0.008681709,-0.032759022,0.021918986,0.067068964,-0.07607167,-0.03267729,-0.005278322,-0.015936656,0.054788493,-0.0075809387,-0.037597034,0.0009827939,0.04247543,-0.08212565,-0.020833032,-0.039268613,0.033934563,0.002063597,0.029064005,-0.06393841,-0.022340124,0.0023605397,-0.08288108,0.093721494,0.044558488,-0.041477185,0.006748766,0.04524857,0.07043846,0.014910569,-0.035901103,0.026602063,-0.06213141,-0.05140316,0.024396354,0.058916375,-0.030072177,-0.002841351,0.048087824,0.0626289,0.033583064,-0.021358736,-0.07456281,1.1760199e-33,0.07333472,0.0038405645,0.062113546,0.08278579,-0.029686889,-0.029042933,-0.086437754,0.043307893,0.009859449,-0.023401394,-0.044485223,-0.011774478,0.044331674,0.027998475,0.037592415,-0.01178625,-0.13281673,-0.030696148,0.06994327,-0.042101994,-0.036564354,0.113755226,-0.0021919757,0.07181735,0.06612886,-0.03595376,-0.05626603,0.0062234895,0.044890516,0.008030987,-0.029092913,-0.092690125,-0.00760502,0.012175704,0.046286725,-0.025216686,-0.034633093,-0.120847896,-0.00048563315,0.13183281,0.08533507,-0.047833968,-0.022444297,-0.07144336,0.04810895,-0.05016207,0.0068100374,0.05438873,-0.01619961,0.031040045,0.05291297,-0.056776557,-0.004069512,-0.058735948,-0.14964546,0.050439708,-0.09308696,0.004668071,-0.024383478,0.03666261,0.022057692,-0.0042904452,0.0015985478,-0.03636163,0.033987556,0.02464722,-0.1376157,-0.02108959,-0.037306312,0.074580975,0.041341692,-0.03198321,0.12704954,-0.006913223,0.035296194,-0.006217645,-0.06562318,0.026544034,-0.01640247,0.06552446,-0.0010563143,0.023518084,-0.03926238,-0.061495695,-0.035219632,0.015046355,0.05151203,-0.051773217,0.00087854726,0.028038148,-0.016940478,-0.12326547,-0.014729967,0.0024191486,-0.08783446,-2.3831067e-33,0.08317072,-0.13641001,0.02682118,0.007946037,0.026978696,0.003713014,0.014656405,0.0038566748,0.008514348,-0.03267341,0.096396126,-0.023798618,0.0027042376,-0.050793882,0.04358982,0.07962382,-0.025385728,-0.05012339,-0.0009229584,0.02535076,-0.06859528,-0.077413656,0.024097284,0.054587223,0.04399569,0.054104514,-0.020104159,-0.038770724,0.009457054,0.06151988,0.0350825,0.0076419343,-0.054356765,-0.051098406,-0.02970092,0.016169112,-0.024702989,-0.03555026,-0.024123518,-0.025225455,-0.056884393,-0.016460624,-0.024249518,0.029120242,0.08745824,0.0030825727,-0.03558124,-0.072621286,-0.051386695,-0.021453608,0.026665311,0.053127345,0.0073075825,0.0032212727,-0.09142074,0.05797059,-0.015597875,0.010397161,0.100145586,0.008375292,0.018188424,-0.06858727,0.043173548,0.036955073,0.037591506,0.06541262,-0.090146355,0.05541166,0.021334141,-0.054120667,0.11796193,0.06680258,0.109295964,0.10976906,-0.01314338,-0.0064194985,-0.037818853,-0.047837164,-0.0035234466,0.009602064,-0.042488907,-0.036470402,-0.038085524,-0.030391803,-0.06827103,-0.010898747,0.0553592,0.08870931,0.0067945076,0.023653194,-0.019534623,0.0065349685,-0.009903087,0.06394315,0.04182526,-2.9505248e-08,0.09131595,-0.07884181,-0.009918549,-0.07665369,-0.01430291,0.056944046,0.05366677,0.03613446,-0.043156255,0.031479515,0.018713333,0.042950563,-0.063428156,0.030651096,-0.0048232144,-0.012752265,-0.043474562,-0.01089866,-0.0014134272,-0.0031249423,-0.06475765,0.050220374,-0.027976062,0.045033984,-0.024014667,-0.027735796,0.055612702,0.072813675,0.03510881,-0.022037748,0.02316019,0.0032002877,0.010097503,-0.050201885,-0.011424866,0.024297893,0.029285807,-0.040811308,-0.07558839,0.06586211,0.047662128,-0.00010253901,-0.04665155,-0.014777952,0.056107003,-0.041752946,0.02941298,0.102426834,0.031749625,-0.01817312,0.028395431,0.020404603,-0.10858069,-0.013521037,-0.081574075,-0.026196353,-0.00974201,-0.065926895,-0.012938403,-0.0419223,-0.103543505,0.009424403,0.19600767,-0.013046859 +6.4.1.6,"Requires Mg2+ and ATP. The reaction involves separate phosphorylation of hydrogencarbonate and acetone, forming carboxyphosphate and phosphoenolacetone, respectively, which are combined to form the final product. The enzyme from Xanthobacter sp. strain Py2 also carboxylates butan-2-one to 3-oxopentanoate.",384,0.99999994,-0.05337914,-0.016942222,-0.036854815,0.0049185785,0.01619018,0.013614096,-0.012701145,0.013443086,-0.023264792,0.0002878797,0.026354238,-0.09790044,0.004626737,-0.012097066,0.026788006,0.04272644,-0.02248731,0.060354013,0.048603,0.01699984,0.15195566,0.042676393,-0.0006171693,-0.05819636,-0.0015819822,0.031564314,0.07845571,-0.05317261,0.009699619,-0.04236641,-0.016656348,-0.028948504,0.03271133,-0.102642156,0.07684197,0.14754602,-0.052978955,-0.051835716,0.053192496,-0.04405766,0.049559813,-0.0046328525,0.016110884,-0.039588824,-0.019995995,-0.04173403,0.07818596,0.01785016,0.014466394,-0.03308793,-0.030849619,0.01770871,-0.08220472,-0.022785833,0.052880473,-0.050126493,-0.06874512,0.018422754,-0.026638223,-0.033495095,0.021605862,0.069970384,-0.013459309,-0.022534395,0.059631567,-0.10041241,-0.009959931,-0.044781204,0.026238775,-0.0038770922,-0.07523008,0.0009880215,-0.012493503,-0.014380101,-0.034426764,-0.016886562,0.03334392,-0.046440598,0.0532595,0.009279385,-0.01821141,-0.007885729,0.040674288,0.039816536,-0.003191869,-0.05777837,0.021233767,0.09386709,-0.004300913,0.099620454,0.050623395,0.027347445,0.035986606,-0.013714059,-0.016692517,0.003455235,0.060693514,0.022106927,0.05321721,-0.012864207,0.015240787,0.04882789,0.061414525,-0.0791348,-0.022055961,-0.017392034,-0.040834203,0.029005203,0.0432243,0.07052019,-0.008922886,-0.081600316,0.015508005,-0.009067787,0.0075869313,0.11773095,-0.013926854,-0.0721893,-0.08960674,-0.026146898,0.021930162,-0.07007364,-0.0100982925,0.052946787,-0.078097865,0.023128642,-0.09950901,6.0037735e-33,-0.008931862,0.03632156,0.022579543,-0.048895534,0.00339336,0.025941156,-0.036024798,0.018580535,-0.035966646,-0.039205253,-0.060451183,-0.08799854,-0.0020628928,-0.006164436,-0.08850508,-0.0774109,-0.10987204,0.05455993,0.07401229,0.059780225,-0.023755101,0.029864345,-0.02037326,0.050794367,-0.002916297,0.07630532,0.017492313,-0.0722991,-0.0011074105,-0.01312768,0.034745883,-0.123662524,-0.06394501,0.047164336,-0.00203451,-0.051870037,-0.04520581,-0.075,0.0089529585,-0.00579537,-0.01161032,-0.0112634,-0.04005619,-0.035758242,0.046374667,-0.07924804,-0.044607088,0.04504831,0.030999867,0.07067096,0.08078918,-0.03619052,0.04216101,0.040055126,-0.06939249,0.030735234,-0.0729134,0.046488166,0.048213724,0.008069498,0.035550933,0.06916495,0.017551515,0.04960581,0.03683764,0.056167454,-0.07181707,-0.06418999,-0.032148644,0.056085292,-0.063931994,-0.070725285,0.07276053,-0.018911878,0.01981518,-0.018199539,-0.036113743,0.026772272,0.032738946,0.019675087,0.053701356,1.8283321e-05,0.0427783,-0.024586406,-0.08718195,-0.0041215736,-0.04945813,0.021953214,-0.030856546,0.081288286,-0.006968625,-0.090788744,-0.04445109,0.059418168,0.019252796,-6.436124e-33,0.08899958,-0.008041844,0.09739451,-0.07410896,-0.017715171,0.048921686,0.045325194,-0.1056584,0.0163823,0.007989681,0.005281815,-0.046081092,0.045276172,-0.016585665,-0.019655416,0.0029442501,0.067957535,0.12801905,-0.03398604,-0.04227469,0.036029357,0.08692542,-0.017798513,0.016994875,0.019923076,-0.0031741355,0.015006371,-0.014262468,0.052813977,0.09661014,0.0015431001,0.022583675,-0.014247789,-0.06747484,-0.068731666,0.002926592,-0.043122917,0.028019732,-0.009351338,0.05695224,0.04010348,0.022124227,0.020039165,0.120919816,0.044772703,0.03573214,-0.010392767,-0.031577405,0.024136662,-0.027547725,0.0011010788,0.016664293,-0.08778689,-0.044026744,-0.0019642815,0.08634938,0.019748837,0.021111598,0.005808637,-0.061909076,-0.09422066,-0.104040444,0.10355694,-0.083405524,0.05545802,0.06310952,0.046094388,0.049681287,0.01156235,-0.02417057,0.1026165,0.07942309,0.050254073,0.014695034,0.00086258986,0.07916776,-0.054712843,-0.07685929,0.03699305,-0.077353254,0.044513892,0.018434297,0.042981762,-0.035855267,-0.027503174,-0.06471696,0.017799795,0.068391874,-0.03988266,-0.018386729,-0.02827695,-0.004614527,-0.009674581,0.058656286,0.07198774,-4.3418407e-08,-0.04005378,-0.06303757,0.116197385,-0.017908253,-0.0025900106,0.10023967,0.028099826,-0.0033727665,0.084929526,-0.076926865,0.0055817734,-0.018040318,0.021775363,-0.009498576,0.054560658,-0.017846553,-0.02767295,0.062683076,-0.06747766,-0.077694245,-0.0774827,-0.071389034,-0.054176915,0.07518634,0.0043167723,-0.07431513,0.038443986,0.029897284,-0.0005455406,-0.04279125,-0.0291762,-0.013982585,-0.04994644,-0.027246697,-0.06357329,-0.003046432,-0.0565589,-0.046442825,-0.008486151,-0.048260886,-0.044866,0.0006452114,-0.012313796,0.025962686,0.032453965,0.062408105,-0.05625665,-0.024349183,-0.07020282,-0.0013067587,0.06089167,-0.024511598,-0.024817424,-0.0931008,-0.02885328,0.10112646,0.0012423459,-0.011283318,-0.024755066,-0.025745597,0.0059018037,0.067193605,0.1549302,-0.043095563 +6.5.1.1,"The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. RNA can also act as substrate, to some extent. cf. EC 6.5.1.2, DNA ligase (NAD+), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP).",384,0.99999994,-0.031416398,-0.07678554,0.033704765,-0.058315646,0.011031677,0.016861493,-0.059777122,-0.019608108,0.008893815,0.11401291,0.040429648,0.059362665,-0.07702653,0.07274943,-0.014095495,0.037518214,-0.16942745,0.030864572,-0.011270018,-0.017761072,0.13740195,-0.0040078964,-0.03263305,-0.011555925,0.013102604,0.045926083,0.04926955,-0.0020703136,0.014308947,-0.085001044,-0.066755734,-0.10121549,-0.072629124,-0.014772213,0.014544308,0.08787495,-0.0075902822,-0.010981936,0.0010977341,0.028824607,0.04984316,-0.046494026,-0.053673595,0.018091353,-0.05620406,-0.026615273,0.021190053,0.0753858,0.040698774,-0.013531804,0.013004142,0.004597701,0.00661399,-0.034624502,0.0009068413,0.042389333,-0.060367476,-0.014167443,-0.0077719395,0.052619714,-0.03257403,-0.01930052,-0.04581505,0.0139728,0.13184243,-0.0560151,0.075208634,-0.038991127,0.010410947,0.016666828,-0.060728192,-0.097083844,0.013113284,0.012431519,0.025119863,0.005647801,-0.04288379,-0.05249901,0.030986773,0.077117704,-0.044462547,-0.036179982,0.032812577,0.06131721,0.022264527,0.007734072,0.0069050216,0.043179356,0.008710945,0.021014929,-0.053248882,-0.007753568,0.02324627,-0.013482007,0.00041106163,0.015887205,-0.0041548195,0.031900644,0.06971976,-0.046145156,0.049794573,0.0546603,-0.041855004,-0.06129816,0.031012466,0.01141233,-0.052623577,0.05899321,-0.028494595,0.030772548,-0.023513215,0.03839824,0.015915006,-0.05404692,-0.059417814,0.08479637,-0.036724824,-0.053712796,-0.0037584181,0.009620323,0.017634995,-0.061336845,-0.013822045,0.06775159,-0.054220736,0.0189623,-0.08041605,1.7467589e-34,-0.018587766,0.019780368,-0.02841137,0.027855096,-0.02904713,0.020763043,-0.0754749,0.039692827,-0.13105908,0.029492082,-0.008360428,-0.03503871,0.0672297,-0.0045776227,-0.009363839,-0.02091075,-0.00819681,0.04428944,-0.04294254,0.0314274,0.0049174526,0.011339442,0.029230965,0.053918134,0.02367962,0.04113676,-0.10364043,-0.010051502,0.07303505,-0.010842204,-0.02793104,-0.073039755,-0.07067229,0.03018806,0.02490132,-0.017744554,-0.05799841,-0.030591749,0.017911606,0.10774967,-0.10128335,-0.062261995,-0.01229873,-0.021231104,0.061512336,-0.054149948,-0.008338835,0.01279142,-0.027421298,0.01832032,0.08125097,-0.07730381,0.10999576,-0.014286817,-0.04998726,0.011600284,-0.025212366,-0.094676,-0.047265988,0.07007583,0.007669508,0.026374679,-0.03561666,0.03294996,-0.026831781,0.03451713,-0.01664155,-0.034137703,0.05261351,0.08121996,-0.040055234,0.06023376,0.021246906,0.017594893,0.0120005105,0.052979082,-0.04479937,0.0242388,-0.0029022251,0.0858489,0.0316179,-0.039708477,0.03063162,-0.004547592,-0.031395078,0.018750146,-0.03541916,-0.09402941,0.025097383,0.057912573,0.067330144,-0.07822402,0.00682385,-0.02957999,0.06839599,-2.6217076e-33,0.16660358,-0.09883984,0.013390846,-0.11516133,-0.061904754,-0.0038570417,0.013441128,-0.030440096,-0.023344494,-0.11146079,0.017669914,0.0076218625,0.0128844045,0.0011263745,-0.05224823,-0.033160925,0.013942135,0.09241148,0.03899425,0.01804555,0.071927264,0.05764109,-0.023351777,0.07796073,0.090573,-0.033657406,-0.040104143,0.015682641,0.07840231,0.06495209,-0.0595849,-0.020417709,0.079186074,0.030493204,0.025492407,0.10135417,-0.033789698,0.01379141,0.05053076,-0.0021090023,-0.0155815445,0.0543293,0.0258456,0.012619495,0.00959426,0.05017701,-0.032049734,0.072975785,-0.063253395,-0.07967633,0.06614502,0.010895942,-0.00093288725,0.014404484,0.0038050285,0.022033563,0.0018185389,-0.014273987,0.007566137,0.036509514,-0.029488588,-0.062085714,0.0016130656,0.0027697808,0.046739288,-0.010650656,-0.03156935,-0.00035625894,-0.044027157,-0.027904917,0.00461666,0.044351187,0.030934833,0.008162542,0.010008358,0.025539463,-0.089199305,-0.051609483,-0.01035837,-0.013871094,-0.013627396,-0.010601381,-0.046517983,-0.023054361,0.08226841,-0.015751295,0.051123537,0.09976301,-0.0051286756,-0.006255498,-0.003764688,0.011677094,-0.023779327,0.059117336,-0.027544739,-5.4063538e-08,0.10411396,-0.076136015,-0.020385541,-0.114629686,0.030092582,0.12913314,0.030127991,-0.035938393,0.088367976,-0.034675136,-0.0013420535,0.0928661,-0.028022846,0.004624125,0.05258304,-0.030253347,-0.06757733,-0.00772864,-0.020836446,-0.060427215,-0.14523807,0.015131085,-0.1453333,0.059398223,-0.03129623,-0.005011909,0.06952704,0.06615899,-0.008669312,-0.013115242,-0.00546126,-0.0011128918,-0.012837266,0.010710192,-0.06271331,0.05834141,0.024506582,-0.005301599,-0.014131165,0.02648494,0.06182151,0.00030184936,-0.046181362,0.0042911377,-0.008829463,0.04670356,-0.004669996,0.022145212,-0.022341399,0.023820128,0.053163137,-0.0040076855,-0.03621839,-0.051215168,-0.08579256,-0.037488442,-0.010478053,-0.07134851,-0.008119976,-0.0093745375,0.008855691,-0.0031544692,0.2300439,-0.06423053 +6.5.1.2,"The enzyme, typically found in bacteria, catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by NAD+, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. RNA can also act as substrate, to some extent. cf. EC 6.5.1.1, DNA ligase (ATP), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP).",384,1.0,-0.04719856,-0.07205286,0.021846222,-0.054765742,-0.0013756788,0.020155946,-0.07787901,-0.0039877202,0.014168489,0.1036358,0.03766006,0.044526868,-0.071778424,0.07784713,-0.019650573,0.023141634,-0.1697805,0.031191109,-0.00210165,-0.009294209,0.13144815,0.023412384,-0.043565173,-0.02951368,0.009991888,0.06499964,0.069242574,-0.012693169,0.0046083233,-0.07859075,-0.0480703,-0.10431425,-0.05259472,-0.014730073,0.044297688,0.088392146,0.0044951867,-0.026091835,0.043890852,0.020192903,0.043758966,-0.033311147,-0.04147227,0.02143588,-0.04083806,-0.016027704,0.040978722,0.080860496,0.04297214,-0.025768718,0.009756193,0.012075798,0.006083884,-0.014382244,0.0037503089,0.036546215,-0.047443166,-0.023957938,-0.0047221594,0.053156853,-0.008733185,-0.023865534,-0.024698332,0.012053871,0.10787786,-0.059890807,0.0780525,-0.050457064,0.011056447,0.0072786217,-0.062322978,-0.09196531,0.0015586242,0.036458205,0.019329295,0.0012447332,-0.031161439,-0.07678406,0.020944478,0.07450392,-0.0537246,-0.04561646,0.036704034,0.062907286,0.023405882,-0.0004494098,0.02439867,0.05451257,0.019336158,0.027043618,-0.05729193,0.006402339,0.029686417,-0.033916663,-0.0014285082,0.013102376,-0.005513841,0.051682357,0.09770335,-0.05362986,0.036133453,0.05523933,-0.031779952,-0.050910234,0.028141795,0.018604582,-0.0422889,0.070972204,-0.009925996,0.027837591,-0.02028252,0.050058108,0.019233545,-0.058462873,-0.045739334,0.06619976,-0.018821549,-0.05452409,-0.023560409,0.022264583,-0.0019846335,-0.086678684,-0.0038594804,0.06276032,-0.045336016,0.032545913,-0.09268224,-9.5519276e-35,-0.023162743,0.010609547,-0.020099765,0.025345024,-0.025900453,0.016331345,-0.059421018,0.04014023,-0.13182333,0.027100923,-0.0143493,-0.03967854,0.054556087,0.0026619777,-0.017849382,-0.014273738,-0.013466538,0.035683915,-0.05251294,0.032043256,-0.0066973846,0.019855669,0.044035763,0.045663405,0.03181728,0.02483704,-0.07539161,-0.022554502,0.077263676,-0.019837633,-0.026287284,-0.0820367,-0.07273489,0.020555826,0.04097758,-0.01136429,-0.052889008,-0.009121256,0.009492624,0.10646125,-0.098173924,-0.0481864,-0.006872289,-0.025522245,0.064105235,-0.051483657,-0.016222823,0.031579085,-0.021816365,0.022704953,0.07935327,-0.07227923,0.104752354,-0.025586763,-0.035277072,0.006483071,-0.028072204,-0.09592906,-0.03826084,0.06844073,0.024601424,0.030092955,-0.05306582,0.045087453,-0.02481746,0.042270776,-0.013151325,-0.036752995,0.05529537,0.08723843,-0.045802064,0.049956623,0.013308838,0.010148704,0.0064296406,0.042154722,-0.06254978,0.008115008,0.014889835,0.07834718,0.025389142,-0.041475836,0.027621407,-0.009188464,-0.039770637,0.015276301,-0.057714943,-0.08396825,0.017435528,0.053399954,0.073682524,-0.07905725,-0.015529035,-0.033290066,0.063234046,-2.6082783e-33,0.16195051,-0.103375226,0.020680146,-0.11109081,-0.07549639,0.00976892,-0.0109093655,-0.031480398,-0.006443308,-0.10448452,0.016488504,0.021299668,0.015497032,-0.0031061815,-0.056920864,-0.036678478,0.013146026,0.09576006,0.023887467,0.012472268,0.07308903,0.050739873,-0.031592887,0.064557515,0.07512045,-0.0320152,-0.0440529,0.03102564,0.07305421,0.055562068,-0.059772465,-0.025380572,0.07788165,0.014259885,0.015768757,0.09262677,-0.03609539,-0.0047735795,0.054947346,-0.011682421,-0.0057815127,0.053483143,-0.0029671944,0.030202731,0.006264141,0.047816,-0.037288796,0.060334288,-0.05774709,-0.07379327,0.062267635,-0.0005353131,-0.0022322072,-0.0035068914,0.012231893,0.022742918,-0.008510465,0.0075529306,0.002506239,0.041428126,-0.025624393,-0.068001546,0.013363903,0.007935234,0.036128305,-0.0036948633,-0.020661771,0.011520415,-0.045601502,-0.025207747,0.004634495,0.054402743,0.017465325,0.0037466413,0.002294005,0.03326242,-0.10073321,-0.06763014,-0.004596074,0.00628892,-0.008928859,-0.019618085,-0.048798196,-0.015502854,0.07614177,-0.017844995,0.059786543,0.0845594,-0.009483533,8.431039e-05,-0.016727591,0.012828941,-0.015755473,0.05708587,-0.041552283,-5.5688197e-08,0.09627416,-0.065439224,-0.01205773,-0.11202483,0.03776837,0.14157669,0.031772606,-0.0327797,0.1021395,-0.029908698,-0.008182413,0.07954449,-0.04111036,-0.0069003548,0.0625045,-0.024248006,-0.08836778,-0.025277007,-0.01881284,-0.046105605,-0.14560191,0.009750744,-0.13447662,0.07359925,-0.02589636,-0.016945306,0.06317977,0.066866726,-0.020219827,-0.011211837,-0.011659718,-0.009499424,-0.0060999594,0.009670339,-0.07519075,0.034894947,0.015931768,-0.01698481,-0.013852507,0.03571723,0.06793121,0.011444289,-0.06037758,-0.0025170667,-0.0028128366,0.07376884,-0.009310842,0.031153407,-0.04743319,0.01925801,0.059717443,-0.0020523695,-0.04482334,-0.04924137,-0.10364634,-0.018952822,-0.0098338,-0.076665856,-0.012906817,-0.0007924612,0.0023314424,0.0005583723,0.2340371,-0.06355449 +6.5.1.3,"The enzyme catalyses the ligation of RNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in RNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[RNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. 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Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a histidine residue [5,6]. The adenylate group is then transferred to the 3'-phosphate terminus of the substrate, forming the capped structure [RNA]-3'-(5'-diphosphoadenosine). Finally, the enzyme catalyses an attack of the vicinal O-2' on the 3'-phosphorus, which results in formation of cyclic phosphate and release of the adenylate. The enzyme also has a polynucleotide 5' adenylylation activity [7]. cf. EC 6.5.1.5, RNA 3'-terminal-phosphate cyclase (GTP).",384,1.0,-0.020932976,-0.035777878,-0.005813957,-0.07510906,0.015415171,0.008585804,-0.036818743,-0.013334366,0.06964345,0.10622033,-0.0071678297,0.0313337,-0.03435333,0.046361584,-0.015543988,0.047146752,-0.1315579,-0.00532431,0.057046846,-0.047199063,0.1392186,0.042267535,-1.3086073e-05,-0.010058301,-0.018621966,0.047623713,0.07624218,-0.00069826754,-0.017072432,-0.04404494,-0.08911061,-0.062786296,0.004264083,-0.030996185,-0.00011072138,0.11180223,-0.0537533,-0.0078086243,0.0022546952,0.09451743,0.07126384,-0.026083712,-0.028295986,-0.023636457,-0.044229146,-0.027026292,-0.005258356,0.04139069,0.07758778,-0.014716002,0.00061437825,-0.05880023,-0.012263939,-0.044366974,0.011960442,0.049704574,-0.069557324,0.020080257,0.00075524126,-0.019576138,-0.011317772,-0.00944308,-0.02543474,0.03557235,0.124845244,-0.06852582,0.031273697,-0.022695256,-0.022055492,0.0015942699,-0.040089674,-0.046413504,0.0021933848,-0.004208822,0.012873732,-0.009828156,-0.010732956,-0.016597528,0.043967158,-0.010901706,0.030704735,-0.012528768,0.021515891,0.060926165,-0.01086671,0.034266356,-0.008041156,0.052962326,0.020484546,0.017090095,-0.013317399,-0.015458784,-0.009238984,0.005062933,0.004550406,0.035713796,0.0024571638,-0.014536817,0.038983237,0.0061278264,0.06402298,0.098408,-0.011378979,-0.09181918,0.007207025,0.0698323,-0.06040584,0.044314392,-0.043210782,0.07287438,-0.04395656,0.018036636,0.005350178,-0.06161522,-0.04241605,0.12846115,-0.052634697,-0.049987994,-0.01950565,0.009915867,0.040797837,-0.08684213,-0.01526392,0.08698165,-0.0713903,0.09043031,-0.090211675,3.4383474e-34,0.04251013,0.0040607,0.01644403,0.0039539775,0.013257894,0.012783428,-0.037369546,-0.001003617,-0.09023842,-0.01928698,-0.04702954,-0.05749201,0.07487339,-0.017026035,-0.014986868,-0.05497495,-0.0620298,0.071652725,0.028914642,-0.01739384,0.04629283,0.013213953,0.00038055822,0.041536156,-0.004114554,0.040591147,-0.1027391,-0.025624232,0.06812113,-0.019535033,0.0127673615,-0.033108346,-0.110888906,-0.0068028728,0.0343777,-0.088234484,-0.083899595,-0.05598613,0.030902479,0.084643476,-0.05386712,-0.0538635,0.020833785,-0.016723327,0.05179486,-0.06105023,-0.029933995,0.008865577,0.027990188,0.05629481,0.12531343,-0.07567004,0.09741482,-0.015971525,-0.060088057,-0.014781224,-0.035237156,-0.08386374,0.0033634137,0.05368018,0.04324098,0.01988776,0.025316097,0.033706177,-0.020533025,0.02929474,-0.07552813,-0.101435214,0.0361418,0.1467397,-0.035030816,0.005471602,0.028194651,0.0021815621,-0.01737452,0.01621186,-0.017164052,0.025892813,-0.03605028,0.067662634,0.028699968,-0.06536117,0.028173089,0.0077157062,-0.037757233,-0.02290592,0.011729616,-0.13153805,0.010132716,0.10829881,0.05330598,-0.05970875,-0.0469992,0.010061072,0.04230387,-2.5551846e-33,0.14379326,-0.042961773,0.04754239,-0.112414084,-0.10670814,0.013051059,0.0232757,-0.05011525,-0.023971751,-0.056376852,-0.021715373,0.04253545,0.066337235,-0.014974624,-0.028866472,-0.02365346,0.045217253,0.08621538,-0.018083718,-0.0037779566,0.08199093,0.06051076,0.0008097665,0.04813455,0.060536593,-0.044894885,-0.00095558626,0.0153768975,0.032435697,0.054523766,-0.008370279,-0.017613139,-0.001163486,0.04515517,0.02178476,0.058333796,-0.032167163,-0.024580635,0.045399025,0.03554487,-0.01755017,0.07543911,0.050364,0.016391754,0.022440879,0.07691433,-0.008474512,0.048528645,-0.030849231,-0.116728984,0.034606546,-0.015563133,0.018691052,0.06486984,0.035211965,0.0062221354,0.0013350673,-0.022200227,0.029044112,-0.021880781,-0.061720982,-0.08868798,-0.014127676,-0.02980187,0.02178431,0.013573017,-0.0024379324,0.0050083217,-0.033071473,-0.0018901646,-0.0019859811,-0.0017254171,0.044414494,-0.0032367373,0.0074712983,0.012277172,-0.016587077,-0.024222964,-0.026211914,-0.06454022,-0.04204982,-0.005574917,0.001641977,-0.043950357,-0.0072067752,-0.05488817,0.08619077,0.11982729,-0.0005020377,0.02927286,-0.004892556,-0.011913374,-0.006729457,0.07105365,0.05737298,-4.8602026e-08,0.026664376,-0.05488707,0.038486198,-0.074998304,0.022602271,0.0896702,0.035856728,0.008109587,0.0722132,-0.055805616,-0.010085793,0.03392952,0.037934944,-0.025961326,0.1067044,0.031863127,-0.10000091,0.020120278,-0.02068523,-0.088277936,-0.1391858,0.009820813,-0.13696048,0.054113623,-0.02808498,0.014705943,0.059856437,0.06262152,-0.03499726,-0.018350324,0.01736589,0.02386553,0.0017821697,-0.04811792,-0.07404299,0.032610077,-0.0026847813,0.025579643,-0.006445458,-0.00945913,-0.009108971,-0.030737977,-0.05978005,-0.0022850186,-0.059655644,0.034259006,-0.02891932,0.054593798,-0.04287854,-0.01722202,0.05738786,0.011651798,-0.033860654,-0.053408,-0.074734956,-0.080649495,-0.0603904,-0.1073132,-0.0019957095,-0.044609774,-0.01784095,0.032543898,0.19139516,-0.030567449 +6.6.1.1,This is the first committed step of chlorophyll biosynthesis and is a branchpoint of two major routes in the tetrapyrrole pathway. 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+6.6.1.2,"This enzyme, which forms part of the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP-dependent. It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST [1]. Hydrogenobyrinate is a very poor substrate. ATP can be replaced by dATP or CTP but the reaction proceeds more slowly. CobN exhibits a high affinity for hydrogenobyrinate a,c-diamide. The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding. See EC 4.99.1.3, sirohydrochlorin cobaltochelatase, for the cobaltochelatase that participates in the anaerobic cobalamin biosynthesis pathway.",384,1.0,-0.02524086,0.00012123637,-0.122850776,-0.05462117,0.08597964,0.032823347,-0.032614138,0.054108668,0.0012756498,-0.05950988,-0.06611823,-0.09106128,-0.082403824,0.010935137,-0.0009782218,-0.007933351,-0.018152064,-0.048538037,0.040909283,-0.04582949,-0.029055832,0.0026214805,-0.0047316994,0.016091788,-0.026758261,0.026351433,0.050553165,-0.012436194,-0.0073010274,-0.016775778,-0.04993093,-0.028179022,0.0077066384,-0.04074957,0.01859367,0.1073242,-0.01090568,-0.046011336,0.048978962,-0.01107773,0.09066376,0.089251965,0.0007151027,0.07003939,0.0055221603,-0.0091082705,0.043165106,0.021371,-0.04004927,-0.011829019,-0.040345684,-0.019725488,-0.053800013,0.06766903,0.0042298613,0.054627378,-0.029718362,0.030117905,0.06365415,-0.08263841,0.012605207,-0.07317006,0.059157062,-0.030600043,0.057144202,-0.008568563,0.037488706,-0.047548655,0.049774587,-0.041236687,-0.049160317,-0.039565623,-0.0697269,0.057581227,-0.052942283,0.092134774,0.0032246923,-0.055473574,0.04349389,-0.018124606,-0.0065786587,0.08533414,0.04551154,0.03237394,0.06523289,-0.05833199,0.010615945,-0.015240426,0.013485383,0.031907924,-0.016919523,-0.0012193423,0.053077765,-0.008430606,-0.14668459,-0.013193211,0.0764824,0.1029424,0.006016972,-0.033520896,0.0559289,0.07220921,-0.04304274,-0.017714007,-0.06004137,-0.013205335,0.08255952,0.16116364,0.035974022,0.085746646,-0.066216916,0.05917505,0.018505901,-0.054587997,0.009585957,0.117033094,0.036485158,-0.011955923,-0.05941272,0.07508982,0.033122525,-0.0487392,0.046053316,-0.03088998,-0.0039744442,-0.026778836,-0.06587965,4.5983017e-33,0.07021223,0.005133248,0.020588212,-0.005372464,-0.010618967,-0.003853933,-0.1215665,-0.010511361,-0.004856221,-0.06995722,0.010005807,-0.068517976,0.03184786,-0.0033262295,-0.08903151,-0.040098652,-0.08347647,-0.024808574,0.033903252,0.026024444,-0.004398793,0.12706514,-0.042653564,0.04738553,0.07259266,0.021207547,-0.016622322,0.045910012,0.0018615498,0.02791488,0.006925858,-0.079751864,-0.118890695,-0.027765874,0.046948686,-0.06088436,-0.041042928,-0.048219286,0.02841771,-0.031188827,-0.020476073,-0.0028910288,-0.043827973,-0.042021014,0.083366826,-0.10334246,-0.008806719,0.1273243,-0.032038406,0.014780697,-0.011361885,-0.035922527,0.06270506,0.026822383,-0.052298963,0.021679016,-0.021018052,-0.0055723367,0.047926873,0.070075504,0.10189437,0.06426712,-0.022765763,0.06807262,-0.0062034116,0.034827,-0.07654638,-0.06497125,0.06088651,0.028430358,-0.031134859,-0.08489062,0.03742433,0.08154244,0.0011619763,-0.04508266,0.00873414,-0.031435296,-0.014000247,0.0028067909,0.0022623597,-0.043303497,0.032477017,-0.06086248,-0.07118667,-0.010976506,-0.01607639,-0.0704295,-0.057973284,-0.017103638,0.046001367,0.0130041195,-0.029407121,0.010257209,-0.034251716,-4.831018e-33,0.07547508,-0.07206879,0.07821685,-0.11086396,-0.065521985,0.044287395,0.04218119,-0.10699262,0.036531325,-0.065293886,0.08400179,-0.045026857,-0.015236414,-0.0024633533,-0.0029275257,0.011030912,-0.038266886,0.07701539,0.011497653,-0.0022178805,0.041865334,0.014209889,0.016224928,0.008849779,0.006202342,0.07608465,-0.024658728,0.09105278,0.084115244,0.07162306,-0.03428385,0.08889416,-0.06347612,-0.04812961,-0.026404401,0.020090157,-0.0035667596,0.01121848,-0.011489716,-0.023559792,0.0036779467,-0.016906006,-0.04237377,0.022961002,0.026356027,0.048090003,-0.047729943,0.028325243,0.0037070196,0.040301766,0.008662107,-0.0006333063,-0.08627944,0.04963481,0.053031746,0.047969386,0.020620536,-0.0089480365,0.04926671,-0.03860634,-0.030422622,0.025742397,0.029088479,0.010499149,0.0358329,-0.0021088556,-0.013251522,-0.007711388,0.056194123,0.07577257,0.03155223,0.088398024,0.031881403,-0.014961613,-0.062200762,0.049493253,-0.004592182,0.013115415,-0.047634423,-0.038140494,-0.06512272,0.029510546,0.06562678,-0.06417675,-0.02819661,-0.04066234,-0.0015930183,0.038662847,-0.049458884,0.0789704,-0.05239191,-0.08328328,-0.016636133,0.04808971,0.0014065055,-4.5586987e-08,0.007596586,-0.054557905,0.04958961,-0.011029306,0.0028610197,0.07743639,-0.07487691,-0.104845725,0.068797976,0.008783739,0.04039152,0.03262658,0.056520164,-0.026367413,0.000359706,0.008976245,-0.04210785,-0.0033179258,-0.023873264,-0.0067073796,-0.05810123,-0.044484805,-0.039625213,0.07738734,0.06643053,-0.05951198,-0.029464884,0.06388238,-0.014353997,-0.029666714,-0.025772655,0.041105464,0.09384462,-0.043395855,-0.024319958,0.033079162,-0.030517638,0.010322527,-0.08745265,-0.028651997,-0.046576492,-0.021919025,-0.10980901,0.0382215,0.08776304,0.00019529776,0.005431415,0.060597867,-0.07265559,-0.0683522,0.04698081,-0.016038276,-0.007983449,-0.02997691,-0.04277286,0.08120356,-0.06903576,-0.06315146,-0.009644996,-0.024557238,-0.055902768,-0.028046936,0.08643652,-0.12230363 +1.1.3.2,Contains flavin mononucleotide (FMN). The best characterized enzyme is that from the bacterium Aerococcus viridans. The enzyme is widely used in biosensors to measure the lactate concentration in blood and other tissues.,384,1.0,-0.020436494,-0.06968687,-0.10977763,-0.012811602,0.06433422,-0.010242916,0.0050647543,0.10191555,0.025917202,-0.024881918,-0.011128584,-0.044344094,-0.14856665,0.13536666,-0.103310995,-0.023393674,-0.046870925,0.0050811362,0.048862115,-0.043921668,0.017351521,0.054109845,0.061004996,0.0055589364,-0.071421795,-0.014559469,-0.006901504,-0.043973982,0.01290273,-0.008051275,0.06218486,-0.043685667,0.081131235,-0.015652737,-0.022898458,0.027397877,0.03834932,-0.10109666,0.043975424,0.012104921,-0.021548117,-0.006663097,0.08139148,-0.013347828,0.047266908,0.020686498,0.029716298,0.02686474,0.019845638,0.10616067,-0.027925417,-0.032372918,-0.06698635,0.061184853,0.04933159,0.013659712,-0.06571093,-0.11725848,-0.058220066,0.023476182,0.01726194,0.08896654,-0.021862514,0.0046492703,0.080275506,-0.012681888,0.027619312,-0.034330714,0.026244827,-0.009732637,0.006085729,-0.040315144,-0.009942195,0.026783532,-0.030097283,0.053572934,0.03945261,0.0050640055,0.052507646,0.042680223,0.030747505,-0.020373426,-0.050330512,0.10089466,0.01918329,-0.0021137819,-0.025134714,0.054002736,-0.026167713,0.058649547,0.001611297,0.020209055,-0.027923753,-0.115008414,-0.045888416,0.021235611,0.0017023064,0.049035303,0.06270511,0.0039241104,-0.034072958,-0.018383445,0.023527944,-0.022402417,-0.114451826,-0.036300693,0.062888764,0.0033364121,0.09625807,-0.013848455,-0.026950728,0.08608941,-0.004749103,-0.04553371,-0.055590518,0.010253492,-0.025853697,-0.08049406,-0.0026612228,0.12948237,-0.041209683,-0.044056848,0.019437484,0.109690696,0.079861104,0.065599225,-0.08158197,6.805895e-34,-0.012271987,-0.018262051,0.06380471,-0.063644506,-0.049494192,0.030046009,0.01441429,0.01844063,-0.047735497,-0.0026292952,-0.0595039,-0.014503997,0.03843327,0.046407666,0.0071921335,-0.026753811,-0.04378194,-0.04096462,-0.012791893,-0.019377448,0.038075842,-0.0045047286,0.03429693,0.054783992,0.07658478,0.019550022,-0.074940965,0.048770946,0.0479517,0.0038439939,0.016849775,-0.10850405,-0.061668694,0.01355851,0.08136028,-0.008937549,-0.08187867,-0.023969244,-0.034111474,0.08593071,0.034278955,-0.003937347,0.009913737,0.024605157,0.0745987,-0.010133846,-0.15120006,0.06902168,0.029436784,0.036133964,0.076308176,-0.03247483,-0.013411562,-0.052381616,0.031130245,0.061747536,-0.033478938,0.018966064,-0.017892674,0.051292963,-0.060841102,0.018882388,-0.026261656,0.030090129,0.047009956,0.043253712,0.03699478,-0.048055463,0.07795928,0.025792815,-0.008191007,-0.04949326,-0.007936664,0.02368182,-0.011605146,0.0015272336,-0.0022393495,-0.011030029,-0.0010668251,-0.0155764455,-0.0101097,-0.023682667,-0.0033282733,-0.015909487,-0.10977511,-0.0091595445,-0.03278922,-0.05625852,-0.025758183,-0.00063138374,0.028025951,-0.05996465,-0.041506555,-0.058695965,-0.0020786216,-2.2171572e-33,-0.0030405947,-0.09087498,0.0009130592,-0.00690487,-0.06850701,0.058765415,0.01247054,-0.039914764,0.04206332,0.0477849,0.08045238,-0.026722547,-0.013151539,-0.056476332,-0.005423639,0.083593905,-0.04334637,0.013097636,0.08981507,0.06188391,-0.02257625,0.07493178,0.058336098,0.014447459,0.0398526,0.021230845,-0.074214004,0.038826156,0.014746882,0.010599173,-0.07445795,0.004051012,-0.0028238106,-0.091138065,0.02588895,-0.01721043,0.057575654,-0.008375374,0.008412865,0.0050827735,0.02402183,0.094646305,0.038774244,0.04049797,-0.06752432,0.106761724,-0.093759224,-0.013873592,0.0071910103,-0.012917477,-0.0051670354,-0.016373457,-0.037742928,0.01840133,0.027016992,0.045705818,-0.008366245,0.014122216,-0.023703309,-0.0049056313,-0.010230273,-0.113651246,0.003752647,-0.010834565,0.047197275,0.027571715,0.03646545,0.04369191,-0.005761254,-0.05469408,0.05643842,0.038005292,0.097305834,0.051029764,-0.085416436,0.013250406,-0.033193797,-0.0047594607,-0.00485037,0.00030358793,0.05153598,-0.014100953,-0.048914447,-0.0321877,0.01713954,-0.010933008,0.017067181,0.03770048,0.03210346,0.017262498,0.00085635734,0.009065572,-0.044917647,-0.0962575,0.011503324,-3.2578914e-08,0.02155665,-0.13947766,0.010742267,-0.06829997,-0.009797172,0.080559954,-0.017284526,0.006752236,-0.053666778,-0.00034427282,-0.010161175,0.09078813,-0.07206783,-0.012756225,0.0520054,-0.06334845,-0.01715802,0.024137363,-0.07350322,0.016136033,-0.07527073,0.07661233,-0.085572794,0.0061230776,-0.016175622,-0.0063261674,0.022018854,0.008169376,0.039667662,-0.007095809,-0.008779994,0.064972624,0.019407736,-0.04559556,-0.18551126,-0.0087638125,0.009567644,-0.035777796,-0.1260237,0.047402434,0.0052669635,0.03846226,-0.0706038,-0.03342074,-0.021646885,-0.0626669,0.052229546,0.063889295,-0.011209436,0.012967213,-0.002225298,-0.040408902,-0.073107146,-0.0016143994,-0.11411043,-0.042454593,0.0017665582,-0.061667424,-0.046085853,-0.04332928,0.037115846,0.03853787,0.1858376,0.013734845 +2.7.11.3,"The enzyme is activated by AMP and is specific for its substrate. Phosphorylates and activates EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, that has been inactivated by EC 3.1.3.16, protein-serine/threonine phosphatase.",384,0.99999994,-0.064806074,0.0074835345,-0.06358284,-0.019128101,0.034685936,0.057195153,0.014140925,0.011932291,0.02916107,-7.903214e-05,0.00323923,-0.01756699,-0.03629282,0.06291652,0.005071105,0.03504878,-0.031180555,0.0075286143,-0.018317943,-0.072358415,0.086357035,0.02961786,-0.021197364,0.013277471,0.03826618,-0.016280115,0.04040301,-0.0035088619,-0.055286705,-0.08680986,-0.05253653,-0.068062745,0.04925652,-0.010547775,-0.009137144,0.08739356,-0.057684,-0.110008664,-0.047833674,0.06733462,0.074826494,-0.041969996,-0.07044764,-0.08419416,-0.023769956,-0.008804515,0.0054468946,0.033403132,0.033730544,0.002219745,0.004528545,-0.08394579,0.022699475,0.041824676,-0.02994216,0.029216457,-0.052411493,0.04769561,-0.0063153515,-0.04449916,-0.0077459724,-0.053057812,0.060566027,0.017559052,0.05465186,-0.041549064,0.055986743,-0.09369661,0.007112414,-0.028314654,-0.06832315,-0.0748008,0.06721617,0.024807084,0.07103372,-0.008720287,-0.006911912,-0.029686743,0.0719696,-0.027507748,0.029457208,-0.042994842,-0.065229304,0.0868699,0.027035953,0.020203903,0.006071805,-0.014487154,-0.026208725,0.018049382,0.04730261,-0.072528325,0.0014165296,-0.0044270456,-0.045111395,0.03443211,-0.03266126,0.054422226,-0.009788617,-0.0050848606,0.016583398,0.11648336,-0.06572876,-0.032101016,-0.018477887,-0.0035089715,-0.008835328,0.091642454,-0.047233798,-0.015543653,0.018430026,-0.05373143,0.079442605,0.021133987,-0.0073001594,0.16623585,0.013684194,-0.06585842,-0.041070715,-0.056201573,0.033115145,-0.053754356,0.022754557,0.04805954,-0.048170872,0.082722,-0.12435991,7.458417e-35,0.058691163,-0.007968854,0.044496927,-0.059743274,0.0036379125,-0.02868082,-0.054218706,0.04827302,-0.010515018,-0.14720553,-0.010726166,-0.020311056,0.10783609,-0.010002861,-0.035816718,-0.07283985,0.003738826,0.03999899,0.051149234,-0.038542252,0.086291425,0.0014065561,-0.028392704,0.054047,-0.031661566,0.031165395,-0.06935766,0.06186562,0.01782737,0.03152585,0.0025146813,-0.042285178,-0.05382203,0.019391453,-0.020173226,-0.041554738,-0.04786552,-0.030404562,0.0047979793,0.049305245,0.0016608973,0.014192918,-0.01396973,-0.018757913,0.010219861,-0.10756944,-0.04668878,0.1083277,0.11747371,0.075693175,0.030819096,-0.075428754,0.11491436,-0.072268,-0.012868155,0.035355113,-0.07983734,-0.047797307,-0.02246441,0.017484907,0.031703766,0.068679705,-0.050189402,0.0884798,-0.037035093,0.082535096,-0.083083145,-0.058478344,-0.016728252,0.06788117,-0.0041100113,0.03579914,0.064582035,0.013496937,-0.020099433,-0.018350156,-0.05165628,0.011156141,-0.05940271,0.07589237,0.018728532,-0.024069356,-0.043505453,0.038038865,-0.06637047,-0.050446283,0.08555783,-0.047592565,-0.025613839,0.020606417,0.028929602,-0.04198249,-0.051361844,0.015983393,0.008713585,-2.2898031e-33,0.13552101,-0.006172499,0.031244425,-0.07660428,-0.004084385,0.055459168,0.08573736,0.0040212334,0.021619111,-0.01365285,0.053029917,-0.009596261,0.016784912,-0.020121252,0.0387737,-0.026936494,-0.06507407,0.003084705,-0.030759457,0.0070767584,0.0008998115,0.025493836,0.015046295,0.082752906,0.055213965,-0.0901833,-0.05095976,0.08230737,-0.0053384844,0.040642828,-0.053007603,0.012403289,-0.03594903,-0.0060854484,-0.00085339847,0.022002462,-0.071395345,0.0022030124,0.036710296,-0.022549134,0.015309432,0.023104953,0.010736985,0.07073296,0.06636638,0.11420022,0.01444351,0.066142716,-0.055356883,-0.07456793,-0.012045323,0.02189398,0.019388815,0.041824527,-0.007684044,0.08646445,-0.034105055,0.086148255,-0.010970773,-0.005822825,-0.0106495395,-0.04960386,0.010361298,0.010475906,0.03848729,-0.05371406,-0.03253921,0.022286892,0.038410667,0.022900581,0.0751359,0.035218798,0.018784106,-0.0039790496,-0.076641634,-0.068388864,-0.123835176,0.013580149,-0.028071927,-0.051735148,-0.000101926504,0.037439466,-0.015564883,-0.08745224,0.030830031,0.048284497,-0.008236553,0.06852235,-0.004753143,0.041446455,-0.095004395,-0.068078175,-0.1270714,0.051072124,-0.02402181,-3.9622492e-08,0.055348814,-0.040814534,0.03674885,-0.05513631,0.053552482,0.04501444,0.05556286,0.015170846,0.029198017,-0.010503586,0.005938633,0.034952812,0.04777652,-0.024045987,0.055797134,-0.016889017,-0.022171548,0.09292382,-0.007714775,-0.046141766,-0.0154367965,-0.06838768,-0.09067219,0.06439081,0.046524607,0.00801953,0.050974883,0.04998546,-0.058125038,-0.08559304,0.05201556,-0.023448277,0.03912449,-0.0145953,-0.049147066,0.049786195,-0.058126792,0.021218784,-0.06346633,0.058621664,-0.023872891,-0.031984385,-0.024880797,0.034612134,-0.00045197172,0.027340159,0.05288141,-0.0054943697,-0.029802058,-0.042782556,0.01193614,-0.06484107,-0.039417222,-0.05016188,-0.08327168,-0.021160677,-0.04509245,-0.08192449,-0.019463524,0.003939763,0.10343519,0.069151126,0.14771694,-0.043726776 +2.7.10.1,"The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.",384,1.0,-0.027652605,-0.045242555,-0.12290915,-0.021457229,0.017762704,-0.07049037,0.068229996,0.058625013,0.0635567,0.022904722,-0.023358837,-0.046469096,-0.06780256,0.092284754,0.020986816,0.037959456,-0.14361037,0.019360388,0.04725113,-0.05142467,-0.040267773,0.07537388,0.06418544,0.0025475388,-0.12668917,-0.058633376,0.0668261,0.0702721,-0.0520102,-0.00896103,-0.044683814,0.032184817,0.0066256463,-0.0033191568,0.011176716,0.051098615,-0.121332966,-0.04291301,0.007905704,-0.07938914,0.08790301,-0.043585777,0.030778999,-0.0071127806,0.01775367,0.060486484,-0.03677282,0.019148462,0.06358458,0.0642549,-0.0061057857,-0.008195204,-0.02701011,0.12096197,-0.060546383,-0.015216402,-0.061669484,7.287828e-05,0.032775298,0.007847291,0.014516914,-0.07238093,0.0054733865,-0.026641631,0.011913286,0.04968713,-0.0020970665,-0.0056982483,0.010003484,-0.055940244,-0.057529327,0.004196731,0.03128087,0.05383215,-0.026042579,0.058578286,0.013264253,0.047463816,0.003907588,-0.09692188,0.0007598901,-0.0025385574,0.026854066,0.010182806,-0.017568734,0.0031046404,-0.035374407,0.060350172,-0.017328933,0.049576715,0.028036866,-0.02878457,0.113730334,-0.04389998,-0.11459183,-0.006017389,0.04516561,0.07678455,-0.00056787225,0.016689884,0.003226516,0.022036301,0.031174365,0.085216984,0.034638572,0.019559568,0.03359481,0.030446978,-0.124748476,-0.05407392,-0.056307293,0.0020096067,0.119129434,-0.00024111143,0.07742641,-0.08028977,-0.039572977,0.040198974,0.10186946,0.077070475,-0.052560035,0.0287807,-0.03314035,0.0124801975,0.07729764,0.0942885,-0.06560866,1.0993275e-33,-0.017300908,0.088720955,0.08553936,0.04610662,-0.026908908,-0.024487061,0.04750841,-0.035979863,-0.062003672,-0.037095156,-0.08956759,-0.07196303,-0.014878342,0.069000915,-0.03270091,0.028432542,-0.03318494,0.01012346,-0.03548431,0.022403087,-0.017830297,0.10450325,0.0016942787,-0.07462285,-0.018470047,0.004690044,-0.04688717,-0.009291814,-0.033467676,0.02140296,-0.07384331,0.037224703,0.0133767035,0.050965086,0.05881171,-0.010285144,0.04124674,-0.010418147,0.005599948,0.020401122,-0.00568522,0.016099285,-0.062172893,0.0075918864,0.037146956,-0.027902601,-0.021931207,0.046628125,-0.06309473,-0.021856815,-0.0066335374,-0.05414787,-0.06387919,-0.029564014,-0.016298229,-0.040731385,-0.05074875,0.018696293,0.046693027,0.009703953,0.028593741,-0.018465925,-0.011045019,0.06564903,0.06904986,-0.029676663,-0.07241201,-0.08074179,-0.08479884,0.07223823,0.048558563,-0.040374327,0.05800277,0.07537147,-0.07401491,0.03086452,0.024641208,-0.035759468,-0.0347045,0.07034665,-0.049190525,-0.034822598,-0.05761437,0.013803977,-0.06202115,-0.003647487,0.07124187,-0.14446682,-0.068708085,0.009077312,0.009882105,-0.010558436,-0.040487424,0.020202044,0.02172859,-3.5368796e-33,0.018073322,0.06886234,0.012324594,-0.06335343,-0.08813542,0.038796373,-0.011041479,-0.05241916,0.021054339,0.054674428,0.07432228,0.046370283,0.03833103,-0.10907128,-0.016680283,-0.08607485,0.03252682,0.030813027,0.030327056,-0.06052461,-0.07092517,0.022861116,-0.0134430425,0.09125554,-0.00695378,0.029792482,-0.061145756,0.08679792,-0.11160889,0.05594087,-0.08816986,0.017789217,0.025733996,-0.0397579,0.058638558,-0.05539332,-0.023238733,-0.03840091,0.0458379,-0.03524363,-0.06765955,-0.0033039942,0.017081069,0.009185546,-0.05641857,0.045216862,-0.009973121,0.024234783,0.03421539,-0.059809666,-0.024187753,-0.018270766,-0.025805796,-0.07034564,-0.040216647,0.015043345,0.008091562,0.014657857,0.03987367,0.03308983,-0.0034710183,0.001983779,0.077527516,0.04911129,0.10141822,-0.027154598,-0.029426482,-0.056443885,0.0700786,0.06849024,0.007297084,0.007293012,0.010157932,0.00066153234,-0.004445159,-0.028868118,-0.062093887,-0.06909213,-0.0061784512,-0.042538464,-0.04719978,0.025793422,0.022720996,-0.0032200238,-0.02406585,0.0012895186,0.018657457,0.037101038,-0.015159492,0.05404818,0.053149126,0.005305192,-0.08939136,0.029267823,-0.033883505,-4.2334975e-08,0.09777691,-0.017734688,-0.04616427,-0.05382392,-0.102123074,0.06766394,-0.052830476,0.052973334,0.039026853,0.061414205,0.031990595,-0.012367839,0.0011272558,0.06298528,-0.0077191372,-0.010692617,-0.03504054,0.03981403,-0.065910816,-0.07545941,0.038930573,-0.015181696,-0.025012925,-0.029376278,0.10123235,-0.056034863,-0.036015097,0.05448903,0.06459076,-0.03379037,0.015010937,-0.09071795,0.004521995,0.008881505,0.12515911,0.072514266,-0.056963217,-0.034326155,-0.075206414,-0.0062878053,0.032907754,-0.0006297786,-0.059364527,0.008715962,-0.07153428,0.012724089,0.06583757,0.07204206,-0.04360186,0.0061473628,0.009766521,0.04621935,0.0056543346,-0.008837625,-0.047551367,0.039796453,-0.026879463,0.021348173,0.06292028,-0.10841692,0.008535254,-0.009700158,0.024758663,-0.051694162 +2.7.10.2,"Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].",384,1.0,-0.035401903,-0.048201796,-0.08886873,-0.04946122,0.029391415,-0.080189444,0.03853886,0.042217717,0.07412169,0.0006840968,-0.0012798037,-0.09991726,-0.072170906,0.0504708,0.053655,-0.00958113,-0.11317665,0.012596296,0.051571976,-0.071737915,-0.03610796,0.06004898,0.07617814,-0.0055973725,-0.11280517,-0.07297042,0.09751542,0.07709079,-0.05095976,-0.05929453,-0.04996688,-0.027049428,0.0017415724,0.003524281,0.011136016,0.03051625,-0.06019183,-0.10651984,-0.023349708,-0.024837209,0.11061797,-0.046391975,0.019486474,-0.028796783,0.048219062,0.057653632,-0.0008610296,-0.02424958,0.024696587,0.029076105,0.0048892717,-0.028315648,0.021869516,0.081919305,-0.04578178,-0.0022015371,-0.06216334,0.045297638,0.0433792,0.013824285,0.061824586,-0.05587831,0.042735465,0.006979196,-0.020524848,0.0032310134,0.039750636,-0.04870061,0.023518965,-0.02395171,-0.04347628,-0.015329833,0.0416814,0.08067969,-0.003232417,0.04700284,-0.006040034,0.0553961,0.008917888,-0.09277936,-0.018107142,-0.05691668,0.031686306,-0.0033126762,-0.07996462,-0.009813447,-0.06376801,0.03480285,-0.086787336,0.0788666,0.048121307,-0.07483598,0.13373297,-0.054370712,-0.08955047,-0.0073650414,0.045170996,0.08745431,-0.051013462,-0.0037940147,-0.04962588,0.0861687,-0.018953934,0.04046485,0.046811353,0.006372658,0.027696151,0.02720294,-0.08599206,-0.07874399,-0.033911254,-0.056786157,0.12025009,-0.015574673,0.05866422,-0.08418512,-0.043750692,-0.011484891,0.09908443,0.088985555,-0.0048837177,-0.026976245,-0.045545146,0.05636933,0.026909407,0.07884134,-0.057167523,5.714802e-34,0.011079011,0.045916423,0.10633479,0.040603556,-0.077679135,-0.003291915,0.0027379328,-0.016539125,-0.023248384,-0.058713175,-0.07013073,-0.08410483,0.042430133,0.092294656,-0.0038616974,0.0057982514,-0.04986721,0.0040729847,-0.023545943,0.03391653,-0.009800955,0.087970555,-0.01401711,-0.062792726,0.024462491,0.008855537,-0.06414196,-0.002865049,0.01829119,0.027495474,-0.106758244,0.018863987,-0.018609894,0.043540087,0.0419974,-0.014973744,0.077173,0.021333095,0.017178675,0.006893577,0.012421464,-0.0037545904,-0.05205615,0.013870808,0.039925292,-0.05573379,0.029782636,0.046799514,-0.031149983,-0.017582053,0.006822183,-0.030599955,-0.056468856,-0.047262177,0.042509414,-0.039401576,-0.032601062,0.028750997,0.017744267,0.03855862,0.039258596,0.009368856,-0.022493744,0.050142694,0.048851695,0.016839886,-0.05799244,-0.086861506,-0.09689545,0.015795968,0.02674521,-0.0048671924,0.11491304,0.05369611,-0.02883861,0.03614505,-0.006506351,-0.021645917,-0.041722994,0.059527338,-0.054808564,-0.025126416,0.0018734733,0.020842304,-0.03651441,0.007998369,0.082987994,-0.09869725,-0.07008079,0.033848565,-0.020221952,-0.009808713,-0.06419157,0.0629503,0.0160666,-3.2261483e-33,-0.0015305089,0.044238545,-0.0054246634,-0.072928794,-0.070533775,0.048364602,0.02515835,-0.024234673,0.054445237,0.029974801,0.13735542,0.029739548,0.043115124,-0.12945841,0.012690702,-0.08701292,-0.045880523,0.045195088,-0.029901724,-0.059366558,-0.050457817,-0.01888083,-0.030828202,0.09302482,-0.008096284,0.0390492,-0.09351365,0.08139666,-0.08052024,0.028551262,-0.10611084,-0.018327646,0.011683378,0.020574579,0.0378077,-0.06781404,-0.029587777,-0.030955575,0.030700164,-0.04638313,-0.03888177,0.0021319666,-0.019694556,-0.01120758,-0.03089498,0.08337719,-0.011552082,0.031604372,0.031523533,-0.03139562,-0.02974076,0.005191579,-0.027983535,-0.019241707,-0.034512606,0.03534345,-0.0017458982,0.038136657,0.093210444,0.050976213,-0.024733076,0.02754195,0.07359323,0.052328125,0.08921935,-0.051651888,-0.08516509,-0.00046540037,0.039405156,0.061745852,0.019214427,-0.020277632,-0.011504519,-0.02569654,-0.006990968,-0.022684561,-0.05598868,-0.083373666,0.0061891526,-0.07895776,-0.026451869,0.024576116,0.009008503,0.012152337,0.057466313,0.06576427,0.03940336,-0.012485038,-0.0029684417,0.038113713,0.030159412,-0.027493067,-0.079818316,0.017270168,-0.013510261,-4.282845e-08,0.088841476,-0.015888385,0.017519332,-0.028900357,-0.05842559,0.033934772,-0.024051009,0.07996682,0.031376798,0.08965861,-0.009236881,-0.0030807317,-0.024590785,0.02883786,-0.008557782,0.0137803415,-0.008050588,0.06393742,-0.028149754,-0.087994345,0.036483716,-0.048896424,-0.07990053,-0.014025378,0.090564676,-0.05868323,-0.03537844,0.048132814,0.041544244,-0.09500839,0.039790135,-0.08133855,-0.011476375,0.04862453,0.10485786,0.04363478,-0.055893622,0.0032467642,-0.094766915,0.052283503,0.0103088,-0.007941252,-0.06317859,0.008444566,-0.056826115,0.011239467,0.07762897,0.069875225,-0.042855185,0.0022061912,0.018268619,0.019809,-0.0043904777,-0.05413042,-0.070558846,0.02540212,-0.021599762,0.012294476,0.056505438,-0.044554908,0.047278993,0.016298667,0.034736477,-0.029284712 +2.7.11.1,This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.,384,1.0,-0.039955378,-0.06912634,-0.0986686,-0.002605803,0.077548586,-0.040782508,-0.0022966315,0.018865485,0.055244327,-0.036359277,0.028238146,-0.001323728,-0.06268622,0.011935842,0.0013701384,0.017669016,-0.104287565,0.0061045378,0.018340359,-0.008766771,-0.017199611,0.037871014,-0.0009806743,0.0189803,-0.04694123,0.042430528,0.013290806,0.031840105,-0.0020495818,-0.010326793,-0.05046831,0.061917026,0.027013002,0.01925335,0.04591182,0.0834556,-0.082333565,-0.009654234,0.02232297,-0.067127824,0.07733038,-0.09095538,-0.0051675704,-0.017966624,0.009277466,0.029484348,-0.079166554,-0.024081532,0.00064069044,0.031871013,0.0033430338,-0.086302795,-0.033344243,0.105790354,-0.0012507769,-0.031937897,-0.09671782,0.006731552,0.0660287,-0.044250187,0.035594348,-0.024084246,0.04350859,-0.053262,0.07925688,0.018194146,0.021395009,-0.037879065,0.046463076,-0.061069533,-0.016178073,-0.04297786,0.064338125,0.12482246,-0.033556294,0.033202674,-0.04107145,0.04548087,0.05216993,-0.051567543,0.044764068,0.023491178,0.02751542,0.13054962,0.009085814,0.018135317,-0.010567373,0.03555489,0.03236303,0.02451651,0.00016985032,0.053067595,0.0030790444,-0.12196091,-0.016393181,-0.010169516,-0.0008079688,0.044252384,-0.04629433,0.06754659,0.04680472,0.004249785,-0.015822157,-0.048652012,-0.021821091,-0.020783927,-0.007942978,0.0072390507,-0.03760131,-0.04355809,-0.09886311,-0.013214695,0.070165634,-0.035950072,-0.05910785,0.01921546,0.017761216,-0.008406359,0.032849684,0.023436079,0.0153520685,0.025013505,0.07984016,0.06517514,0.0002436898,0.03611287,-0.11069102,2.181844e-34,0.027346207,0.057823252,0.10773894,-0.056987144,-0.027242221,-0.06585736,-0.0110775605,-0.04986341,0.008771567,-0.07379236,-0.10493559,-0.07213626,0.037323218,-0.013263292,0.004250337,-0.07866878,-0.039272156,0.03867722,0.07541518,-0.030081235,-0.01508504,0.15627924,-0.019164609,0.008948178,-0.056197036,-0.033570424,-0.074756116,0.00907247,0.0009010491,0.02106944,0.0032457388,0.012997882,-0.0016563989,-0.012091641,0.03850151,0.025274517,-0.061004363,-0.038518764,0.02897291,0.062156145,-0.00037323506,-0.023169804,-0.042895563,-0.017906284,-0.0013042814,-0.0771775,-0.05726984,0.09979694,0.0032570586,-0.00032076112,-0.0040585054,-0.058200575,-0.0018004518,-0.084600955,-0.05022075,0.0010868451,-0.017360557,0.016314978,0.024797663,0.044110294,0.060304314,-0.005973451,-0.076808326,0.04943733,-0.024490066,0.018695375,-0.1326174,0.030005408,0.023961246,0.06578582,0.063798614,-0.0117066745,0.116242476,0.044516355,0.012028957,0.0056243697,-0.08046737,0.07732017,-0.08124156,0.08495474,-0.0025226756,-0.05483844,-0.09664956,-0.015197019,-0.1249802,0.019810826,0.05239232,-0.050475694,-0.104438916,0.042458445,-0.001560461,-0.06792302,-0.06593186,0.009399954,0.033419497,-3.6733372e-33,0.03712241,0.029514879,0.034068722,-0.006540449,0.008517557,0.07929598,-0.0006917942,-0.048017193,0.030875076,0.09792748,0.08986643,-0.04325028,0.042465806,-0.05325653,-0.015036882,0.024571773,-0.09063559,0.038833395,0.023702852,0.031463776,0.0042873,-0.0081951255,-0.021486484,0.09883615,0.028305031,0.033618633,-0.020289043,0.108585104,-0.031708498,0.09663653,-0.017511383,0.010894225,-0.03801794,-0.05749328,0.00080492435,0.018654186,0.015599865,-0.03959123,-0.0070967735,-0.11075085,-0.036488313,0.006313849,0.054482255,0.10898128,0.032890644,0.06002799,0.054421384,0.020893158,-0.011166599,-0.10752364,-0.012817303,0.02996639,-0.041026928,0.0052581835,-0.029182894,0.12877439,-0.05193845,0.042235143,-0.089350775,0.009840588,0.013421904,-0.06964319,-0.012133217,-0.013945269,0.08047673,-0.05102302,-0.017470554,-0.003740986,0.05229451,-0.017296316,0.045251932,-0.0026975893,0.027246926,-0.044641398,0.001802143,-0.011286392,-0.013555244,-0.005672799,-0.059279833,-0.096688546,-0.039331596,-0.031962294,-0.020905444,-0.011404629,-0.0791473,0.03943154,0.037559398,0.07379879,-0.05516345,0.020004012,-0.033626825,-0.015101475,-0.10960572,0.12650633,0.0078414595,-3.8096534e-08,0.08666035,-0.07394603,0.004193669,-0.037978474,0.03138828,-0.0017785161,-0.01003041,0.020987164,-0.0052358415,0.015366454,-0.01477112,-0.0055073923,-0.022593692,-0.07263241,0.030267624,-0.01889761,-0.06661097,0.04886561,-0.054417964,-0.091086276,0.020549448,-0.085302435,0.037390497,-0.007871428,-0.0065267463,-0.022233406,-0.008904373,0.010527446,-0.06221642,-0.10195982,0.050975755,-0.0029411907,-0.038208228,-0.0636685,0.0076673795,0.12654606,-0.05641466,-0.06007148,0.0005336464,0.01987487,-0.034166478,0.030613333,-0.05434348,0.0622253,-0.018835865,0.023494866,0.022760324,0.015646376,-0.04660477,-0.056408834,0.013931498,0.03898935,-0.03184636,0.0337021,-0.06566159,0.08059444,-0.023711402,-0.015024496,0.0572918,-0.037189372,0.06900179,-0.009186395,0.099383235,-0.015471396 +2.7.11.2,"The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring).",384,1.0,-0.0044592647,-0.042069953,-0.07724131,-0.0010888206,0.084443904,0.009217825,8.6802705e-05,-0.023323452,0.011238434,0.001008598,0.07420336,-0.018808994,-0.09019333,0.048791915,0.047642983,0.07343212,-0.06766908,-0.03377741,0.057139948,-0.071690015,0.057040688,0.025997456,-0.010981527,-0.016573949,0.021446034,-0.06970581,0.05247836,0.0037587185,-0.013326068,-0.06145706,-0.04629404,-0.047114406,0.029067835,-0.0059175063,-0.024186881,0.14858638,-0.07982268,-0.041242275,-0.03072065,0.00665637,0.086248234,-0.06767929,-0.06334326,-0.060127024,-0.051190954,0.0072837113,-0.023285279,0.042359907,-0.01233229,0.0028396056,-0.0019739878,-0.01201857,0.026157117,0.027587345,-0.017595831,0.04278317,-0.043723024,0.028576814,-0.029229263,-0.06591473,0.013552743,0.014380414,0.010875438,0.024139198,-0.02270012,-0.029789608,0.08285615,-0.12501417,0.0071664653,-0.040361907,-0.023999734,-0.12902075,0.032999545,0.0267225,0.018109566,-0.010274617,-0.028945314,-0.023503324,0.055943035,-0.03611873,0.03859606,-0.052589126,-0.00017333595,0.00095273246,0.038980763,0.07640813,0.021561373,-0.05256347,-0.02039145,0.050878555,0.016978212,-0.04346998,-0.049195975,-0.055995803,-0.017049221,0.033459228,0.040499456,0.05321662,-0.048919175,-0.02792351,0.040097713,0.113825046,-0.07353388,-0.066262424,-0.0456882,0.030703409,0.024109345,0.010615945,-0.00860627,0.0017516896,-0.031616155,-0.03042897,0.07007922,-0.007595819,-0.0066841813,0.12494521,0.019643938,-0.071494706,-0.028810142,0.018228194,0.07358487,0.0037316908,0.023860486,0.065523244,-0.06643136,0.02882783,-0.07262451,1.3724857e-33,0.027442904,-0.00920278,-0.023644548,-0.02329517,0.008381571,0.005899896,-0.048750002,0.03893016,-0.039050817,-0.09980716,-0.094193734,-0.032514222,0.07642749,0.03392877,0.012006624,-0.035408627,0.025372697,-0.0065616816,0.1856283,-0.014026715,0.035378892,0.03545422,-0.05366771,0.03769857,-0.035058483,0.06301178,-0.033048,0.053460434,-0.006759386,0.013685236,0.021410335,-0.07825616,-0.11943197,-0.0052150846,-0.06569758,-0.032277174,-0.060843542,-0.07123257,0.022431348,0.02852093,0.00061613915,-0.0057330937,0.012181723,-0.010288848,-0.02065131,-0.06921885,-0.005036153,0.0780619,0.04219757,0.038963232,0.07831645,-0.082718745,0.1137879,-0.10568445,-0.048378818,0.08184309,-0.043706693,-0.0019368107,0.012956013,0.043208692,0.03952075,0.02337735,-0.033159714,0.07526983,0.044954076,0.03603697,-0.054538574,-0.096929684,-0.021055741,0.047061693,-0.03413673,-0.012123846,0.08551386,-0.008845525,0.045304768,0.004652856,-0.07225707,-0.0030292494,-0.023132648,0.05191871,-0.0125350505,-0.055914033,0.041095134,0.033236317,-0.011718818,-0.018757131,0.0039899703,0.0058247144,-0.036395684,0.039111055,0.033885796,-0.04597082,-0.05823038,0.050545953,0.06924523,-3.9791623e-33,0.10681107,-0.04076469,0.036213756,-0.072007276,-0.02166325,0.1174628,0.049798835,-0.061233766,-0.005084265,-0.0099357115,0.053970963,-0.072745115,-0.01841404,-0.0379738,0.058725853,0.028365517,-0.06464121,0.057634175,-0.03034601,0.029671324,0.00040381786,0.05032937,0.0106083155,0.07120736,0.05218656,-0.035818703,-0.011118638,0.043772828,0.017421653,0.0013136086,-0.06688614,0.03924721,-0.030825067,0.01546476,0.008608136,0.066023886,-0.023273077,-5.0277395e-05,0.005239233,0.0073840604,0.042633697,0.07926274,0.0034610415,0.049610257,0.041935552,0.06894739,-0.048762694,0.018035622,-0.05490544,-0.05622351,0.019894268,0.05502567,-0.008799052,0.0032060647,0.081767656,0.13579516,0.011619115,0.016328953,-0.019176044,-0.032499284,-0.0768108,-0.041976202,-0.0025775395,-0.0018973161,0.05175036,0.0077972515,-0.028025601,0.0027017207,-0.01217437,-0.02899077,0.097812906,0.04526924,-0.04374851,0.009488204,-0.07887275,-0.005070924,-0.035204075,-0.03615521,-0.0045704697,-0.10281029,0.030406078,-0.01066616,-0.042467304,-0.0956187,-0.056804202,-0.042626686,0.0059128357,0.057990655,0.011786236,0.0110952305,-0.0016257665,-0.034880396,-0.090729065,0.024369407,0.041822955,-3.8358294e-08,0.009016607,0.0008337034,0.06632692,-0.09399647,0.06367986,0.02544953,0.107100144,-0.035957344,0.0027448079,-0.040214583,-0.03713839,0.05639626,0.0706928,0.008006706,0.07769855,-0.002128215,-0.002370531,0.06660025,-0.01629935,0.0031807644,-0.0055620866,-0.065142065,-0.14850537,0.06934483,0.013732593,-0.0496062,0.08245866,0.061198004,-0.0010716004,-0.07358377,0.00921262,-3.243184e-05,0.028817287,-0.023288278,-0.037566796,0.047175415,-0.0058258064,-0.05342162,-0.06924081,0.055911414,-0.03348339,-0.049991447,-0.038382415,-0.009755544,-0.03820078,0.04609841,-0.034303885,-0.01570666,-0.0061344295,0.0061764517,0.042764466,-0.021137463,-0.022169938,-0.044338487,-0.10008493,-0.035216443,-0.021685068,-0.12032148,-0.0054889023,-0.05278954,0.12165812,0.06535035,0.15343033,-0.061948016 +2.7.11.4,"The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).",384,1.0,0.018540742,-0.05215446,-0.06611494,-0.017201908,0.09251093,-0.032595135,-0.0036741875,0.009883466,-0.006437184,-0.0065774866,0.089621544,-0.033120517,-0.05609438,0.012597886,0.026566088,0.11247969,-0.06730665,-0.014099734,0.042854216,-0.060754582,0.054420218,0.025954746,-0.013606813,-0.010909299,0.008667066,-0.034419797,0.045384422,0.021568464,-0.019333255,-0.06563415,-0.013237874,-0.039557494,0.008995497,-0.005814059,-0.037130006,0.1215145,-0.056217816,-0.04578406,-0.04288316,0.019646691,0.09560575,-0.051354732,-0.052625097,-0.06123158,-0.03423699,-0.0022530803,-0.035532355,0.03634718,-0.001630076,-0.007207682,-0.0032988745,-0.06763319,0.04903512,0.052322276,-0.006880631,0.04547504,-0.027875157,0.03458946,-0.026810378,-0.016981041,0.02552324,0.018851006,0.031291798,0.022652859,0.016741714,-0.018224377,0.043974124,-0.12690488,0.0135894185,-0.041471276,-0.02908161,-0.116203964,0.025409177,0.016545046,0.016538804,-0.018280432,-0.023587832,-0.01948838,0.066577576,-0.07346869,0.021542007,-0.05634344,0.02826321,-0.0010601361,0.014537541,0.047044173,0.015617842,-0.057455145,0.01811827,0.08015181,0.014738448,-0.0073464797,-0.030100843,-0.033654835,-0.033647522,0.03304084,0.021602156,0.08702043,-0.084967,-0.00053853507,0.036171604,0.11192963,-0.08171872,-0.091212,-0.048175205,-5.8526333e-05,0.034250587,0.003894389,-0.02106537,-0.0011280751,-0.024597058,-0.047004405,0.06306657,-0.012582451,-0.02365682,0.12808086,0.041699942,-0.053841345,-0.05333557,-0.030616177,0.062958375,-0.022735834,0.023840997,0.0011195824,-0.100532316,0.007826868,-0.10014011,8.652177e-34,0.04263662,-0.01838742,-0.025709597,0.008115899,0.014788445,0.0027612518,-0.05412147,0.03025418,-0.0129736755,-0.11833509,-0.08814026,-0.04992795,0.06309873,0.028206233,0.034447465,-0.06294156,0.02648696,0.014330155,0.16863073,0.0016542902,0.04608103,0.028680414,-0.0818,-0.0016198455,-0.007969553,0.068146415,-0.03131055,0.018812487,0.016983775,0.037524085,0.0028845037,-0.07958472,-0.14542858,-0.020974182,-0.036373135,-0.054421157,-0.0802264,-0.06106574,0.005875203,0.0230798,-0.00039313565,-0.011112637,0.011796951,-0.010745653,0.0052614952,-0.06683114,0.016931975,0.085839994,0.06797503,0.077835254,0.065983474,-0.088078484,0.10343045,-0.09545544,-0.029823795,0.073151454,-0.06708094,0.009873076,0.023565672,0.04149471,0.036290288,0.04908993,-0.03222547,0.07105264,0.058009572,0.040445644,-0.06382068,-0.10422011,-0.009413034,0.0073642367,-0.008451696,-0.011511239,0.09162009,0.011748738,0.027850784,-0.021131082,-0.07791427,-0.020570576,-0.014465024,0.053183243,-0.003960138,-0.0577444,0.024649275,0.015883999,0.022771124,0.016026895,0.013907508,0.006466066,-0.08494646,0.05094034,0.05059286,-0.041570857,-0.08129565,0.038483504,0.08983992,-3.2773554e-33,0.10313536,-0.024770215,0.028429104,-0.06698759,0.0045138453,0.07238472,0.027679348,-0.01673059,-0.013917359,-0.0064798584,0.095019504,-0.051856082,-0.028759945,-0.036850654,0.042484336,0.018099174,-0.06974,0.06011738,-0.03087115,0.0064415615,0.055227056,0.03955287,0.010937831,0.092709474,0.032960378,-0.031042598,-0.0039456123,0.025147047,0.0203755,0.022522803,-0.07711724,0.06331486,-0.006571113,0.026616624,0.011955932,0.062317967,-0.015260976,-0.025113635,0.010691326,0.0045888145,0.005457009,0.06134472,0.001318973,0.04875497,0.028958106,0.0686187,-0.07253483,0.013825866,-0.019590972,-0.081258334,0.018188324,0.043145802,-0.0020758696,0.029352004,0.08327801,0.10581253,0.007166494,0.064139344,-0.042931594,-0.03579699,-0.071527705,-0.027103974,0.012979275,-0.0029233405,0.066100955,0.022520684,-0.0220583,0.018731724,-0.010124863,-0.0363157,0.083324976,0.03428524,-0.05778781,-0.015222151,-0.0886678,-0.0222395,-0.04609915,-0.027590616,-0.016779302,-0.070573196,0.042084716,-0.027722968,-0.009985518,-0.08619674,-0.04545127,-0.06178251,0.018231185,0.050248053,-0.022320988,0.020497872,0.0015129158,-0.02201537,-0.11391116,0.06238709,0.018831495,-4.146038e-08,-0.020088477,-0.028067905,0.07596029,-0.10817199,0.08828722,0.038209826,0.058753423,-0.028092803,0.0067914273,-0.037348676,-0.011818034,0.06639752,0.039686006,0.027602926,0.095882714,-0.021580271,0.016851036,0.06161035,-0.023329282,0.00092208013,0.0027845905,-0.0792186,-0.12322443,0.06279539,0.019775674,-0.036637697,0.07539874,0.045942817,0.015859956,-0.060171735,0.01666794,0.010002142,0.019022806,-0.006420781,-0.0657673,0.035662107,-0.036778253,-0.050698366,-0.12035913,0.05484002,-0.023763109,-0.036163427,-0.017376948,0.014134681,-0.015686857,0.03887993,-0.029738734,0.010680855,-0.026930124,-0.013700099,0.0570028,-0.025343986,0.008077377,-0.022916118,-0.12389443,-0.015078645,-0.01585869,-0.11009036,-0.03102265,-0.026301622,0.10775188,0.05472914,0.14493154,-0.025450733 +2.7.11.5,"The enzyme has no activating compound but is specific for its substrate. Phosphorylates and inactivates EC 1.1.1.42, isocitrate dehydrogenase (NADP+).",384,1.0,-0.0021021126,-0.05281752,-0.049252976,-0.029764464,0.06408791,0.015852513,-0.028407523,0.0010383022,0.0147942,0.0020452987,0.075638436,-0.02187349,-0.09554758,0.0617468,0.03987411,0.057041537,-0.012838063,-0.008816232,0.04344192,-0.041956674,0.035865404,0.015719634,-0.011028936,-0.0023906233,0.062164877,-0.027782967,0.03373342,0.025550691,-0.024362402,-0.062931195,-0.02811047,-0.023873761,0.037998825,-0.03380377,-0.027138924,0.096842654,-0.05876555,-0.03875467,-0.036592983,0.03222343,0.049959745,-0.061114926,-0.11489786,-0.04969663,-0.052610513,-0.039346892,-0.03618251,0.07332816,-0.0018754868,-0.001410646,-0.011119924,-0.02294639,0.058969464,0.021361021,-0.03203256,-0.010081376,-0.026384374,0.05788479,-0.04413196,-0.108076096,-0.013618612,-0.052203435,0.05369186,0.04632803,0.036212787,-0.015571573,0.08100482,-0.10891978,0.014063436,-0.007760645,-0.08252575,-0.09716657,0.040639427,0.00818429,0.0043363087,0.027081486,-0.055755846,-0.02226312,0.089214064,-0.0339561,0.059739165,-0.026757322,-0.014244282,0.026775837,0.029801888,0.06043372,0.04982525,-0.012652796,-0.02265111,0.027462408,0.006416627,-0.016032163,-0.055055395,-0.019078052,-0.069692895,0.017793635,0.0085767675,0.045041166,-0.06456344,-0.04561855,0.033544727,0.123404145,-0.09321551,-0.054933593,-0.02865924,0.005631715,0.0038752006,0.027770039,-0.044201806,-0.006167532,-0.018515896,-0.05434731,0.077920176,-0.032055832,0.009629666,0.11115192,-0.001449137,-0.055170927,-0.05173766,-0.0411013,0.055331916,-0.049089015,0.009121135,0.047231212,-0.08506124,0.036510147,-0.07878172,-3.4832664e-34,0.06405906,-0.012768839,-0.02882484,-0.036844335,0.008657261,0.020857278,-0.03774229,0.06490636,-0.06642056,-0.10598884,-0.0798879,-0.052342016,0.08013257,0.013431348,0.043738578,-0.013618069,0.029374612,-0.004977227,0.14246845,0.0015239127,0.04098021,0.051265117,-0.06896604,0.036420483,-0.009817914,0.066489905,-0.079081886,0.07406313,-0.055319466,0.0070291474,0.03431111,-0.06436709,-0.1472976,0.0067566806,0.01568288,-0.028538574,-0.05436857,-0.04720008,0.021256786,0.01980546,-0.011902596,0.041877102,0.0152201345,-0.026549673,0.035509545,-0.05660488,-0.020507507,0.085185,0.06967035,0.057639014,0.07479976,-0.04600334,0.116768286,-0.14620794,-0.01764671,0.07812161,-0.06612313,0.009879698,-0.011929905,0.060210116,0.008389888,0.05077069,-0.02799228,0.07784245,-0.031108268,0.06450725,-0.083771445,-0.076386385,0.04630572,0.038422376,-0.0017556434,0.04272368,0.06431113,0.005588558,0.03125777,0.0017114144,-0.033653796,-0.026742248,-0.008361601,0.09402469,-0.011015152,-0.061022606,-0.01486335,0.011164133,0.009073254,0.018672839,0.024806086,0.021777924,-0.027608365,0.039254636,0.04368498,-0.061305963,-0.035153057,0.025991032,0.06460823,-2.2286366e-33,0.1172064,-0.008628596,0.012144008,-0.07124389,-0.0060403426,0.1375361,0.030691035,-0.062112264,-0.0006782044,-0.016112924,0.07693737,-0.028621009,-0.023588005,0.0026319684,0.01190672,0.02454552,-0.08893652,0.04462245,-0.025735306,0.045457188,-0.013246223,0.047900412,0.021456897,0.0737478,0.053264514,-0.04992452,-0.028285997,0.057762746,0.018550249,0.0042860773,-0.053631466,0.0722478,-0.0686883,0.005988313,0.023410428,0.054187022,-0.042841554,-0.019716015,0.010922431,0.010104289,0.014213267,0.053723574,-0.029220063,0.05092386,0.06752295,0.056019593,-0.030673657,0.015418948,-0.0530571,-0.07894738,-0.001491992,0.07554971,-0.023654044,0.061562087,0.07470017,0.12939519,-8.4223706e-05,0.07320328,-0.0045600506,-0.004065139,-0.035853393,-0.027040873,0.0013154189,0.018707678,0.04556162,0.009320353,-0.010252066,0.010074408,-0.0062767765,-0.059616953,0.09144062,0.022506488,-0.0035687168,-0.010857005,-0.068470255,-0.017405841,-0.07791853,-0.050554533,-0.04001664,-0.07283802,0.035489593,0.0035950267,-0.045206845,-0.08729048,-0.02422679,0.002685612,0.00085399835,0.016088998,-0.028500853,0.048981976,-0.0036511717,0.013173311,-0.09134442,0.03096947,0.021383531,-3.164176e-08,0.038268585,0.0065424736,0.07072154,-0.116718605,0.073367655,0.042555764,0.07703444,-0.075123005,-0.0013683125,-0.016758265,-0.02444951,0.07334462,0.034229685,0.03060769,0.07883519,-0.04081725,0.010953772,0.041696176,-0.024986427,-0.0071972706,-0.024932647,-0.035213783,-0.14449188,0.05100742,0.0143319825,-0.049267843,0.044513404,-0.005548973,0.041282836,-0.054672085,0.035855938,0.012727947,0.06820917,-0.014025615,-0.022083834,0.03888582,-0.037322853,-0.014325345,-0.10357188,0.064726785,-0.03285142,-0.08569974,-0.016898723,-0.024000214,-0.019638613,0.046301704,0.013163901,-0.04983853,-0.052059866,0.00022976474,0.06073431,-0.04831459,-0.008619826,-0.054396626,-0.05835,-0.028210174,-0.011019341,-0.115029894,-0.03766383,-0.025906565,0.07436175,0.020442663,0.1257247,-0.06678571 +2.7.11.6,"The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation.",384,1.0,0.0038964124,-0.07461783,-0.061520822,-0.03251967,0.06475087,-0.053865664,0.047153153,-0.0046824473,-0.015947305,0.03387191,0.050403684,-0.0718614,-0.015366474,0.09549849,0.052834027,0.05128776,0.0033860903,-0.017461138,0.04687038,-0.08369956,0.06590402,0.0060451976,0.011374603,0.0063595977,-0.0040217796,-0.022532409,0.025471501,-0.01703554,-0.007362551,-0.009830891,-0.039557807,0.008000906,0.09594685,-0.067201205,-0.026452791,0.096134394,-0.07234515,-0.056992695,-0.050859235,-0.0038717834,0.017588053,-0.093339644,-0.013881979,-0.058401413,-0.040304273,-0.08009065,0.04523399,-0.004046366,0.047767963,0.035092704,-0.03621266,-0.04269616,0.044367407,-0.006034574,-0.011309591,0.02681553,-0.11434035,0.043355364,-0.014114187,-0.046685666,0.0015441142,-0.016319089,0.0026900799,0.02736829,0.0138951335,0.0041555576,0.02861984,-0.11918904,-0.010491593,-0.018692775,0.0197851,-0.089954026,0.0054791304,-0.060132902,-0.053566337,0.035214722,0.051185172,-0.059093725,0.08621505,-0.027721489,0.008247909,-0.044167705,0.054899134,0.06513355,0.02645119,0.041550774,0.00819439,0.010406469,-0.022927979,0.116172776,0.10869301,-0.0016388556,0.009013514,-0.0051843165,0.023986235,-0.0013768264,-0.03524322,0.047536083,-0.017848494,0.011819601,-0.010673802,0.10012337,-0.08489356,-0.018573355,-0.04655172,0.026831565,0.016684381,-0.006374857,0.0097190365,0.0037006286,0.014775172,-0.047986835,0.117064536,0.024263235,-0.00786614,0.123747446,0.026081778,-0.114026606,0.011633411,0.02177051,0.073046096,-0.026391217,0.0058760745,0.0026991602,-0.019910997,0.058796916,0.010697219,6.417278e-35,0.046929583,0.059396386,-0.0028272467,0.0012315384,-0.031554606,0.046201274,-0.018915284,0.0131115755,-0.058109287,-0.05825843,-0.12325094,-0.044695646,0.02805241,0.048246402,0.0011678078,-0.05260168,0.03561901,-0.017172337,0.11218594,0.047928855,0.011490695,0.055328667,-0.077163585,0.010706876,-0.05003706,0.10077286,-0.02799759,0.02709386,0.010436936,0.025937669,0.016622186,-0.06550328,-0.094320126,0.03981753,-0.02559883,-0.024460452,-0.041940082,-0.027781546,-0.013909531,-0.0043361764,-0.020254467,0.052553058,-0.05061176,0.009368753,0.06275229,-0.08007645,-0.021376222,0.11985378,0.09717982,0.10535212,0.10984185,-0.015040622,0.033575054,-0.054181766,-0.011544457,0.09509644,-0.08152753,0.04952865,0.11530517,0.016931474,-0.0073380363,-0.019257307,0.030266419,0.073757075,0.08346161,0.08551097,-0.062587336,-0.077312596,-0.029290538,0.045406517,0.00961226,-0.016757214,0.0120752845,0.025248775,0.039079387,0.016806806,-0.04662726,-0.055019457,0.013167304,0.0025055013,-0.018554823,-0.07621728,0.030415932,0.030678252,-0.03991231,0.050968446,0.015834678,-0.03638327,-0.042938076,0.02620491,0.04377886,-0.05698518,-0.101692975,0.055582505,0.033802185,-1.7520291e-33,0.08786921,-0.022935245,-0.011971355,-0.10981368,-0.0649278,0.11045199,0.008988846,-0.11286711,0.0308952,0.023011839,0.1159846,-0.05153851,-0.030749895,-0.08351092,-0.014564834,-0.039997596,-0.032638118,0.053934813,-0.07823672,-0.007897601,0.008818444,0.021716857,-0.023441402,0.0853403,0.05561957,-0.010368515,-0.044178993,0.050903976,0.039670378,0.07224892,-0.053630136,0.057262056,-0.017839383,0.043655872,0.044624053,0.07123778,-0.010167153,-0.007759246,0.029215805,-0.012408688,-0.012648691,0.02083888,0.045855876,0.070888944,0.00987507,0.093729116,-0.045552246,0.0138001125,0.007900769,-0.083357036,-0.050142102,0.007689756,0.007265273,-0.0032619475,0.043808937,0.08053683,-0.0062307063,-0.034675837,-0.046250865,-0.019854607,-0.009861671,-0.018730247,0.029418495,-0.02300542,0.027326949,-0.014428209,-0.06674725,0.028626552,0.046926945,0.009218875,0.027557462,0.030401519,0.040755276,-0.028908063,-0.061467875,0.020902278,-0.042467836,-0.071527466,0.037760023,-0.14019103,0.038374286,0.063926056,-0.014086138,-0.058979746,-0.052979104,-0.075986505,0.017136155,0.004892823,-0.014778679,0.022465222,-0.04320424,-0.01687729,-0.12243397,0.008809426,0.03243745,-3.774561e-08,-0.0065290383,-0.033208776,0.06270158,-0.08630636,0.009067328,0.117872395,0.02288801,-0.06179149,0.025024878,-0.05342283,-0.008444684,-0.007433438,0.0125521645,-0.0067237923,0.05152066,-0.047363773,0.009956632,0.026962731,-0.04745209,-0.06521299,-0.026172591,-0.07706027,-0.08799348,0.00038189656,0.012016967,-0.055862192,-0.00025489292,0.09844549,-0.001603959,-0.012899803,0.0068808272,-0.0010347648,0.013341224,-0.017681645,-0.04740575,0.06405723,-0.052889235,-0.01822793,-0.094426654,-0.061945975,-0.047891896,-0.02729707,-0.008202899,-0.04655235,-0.072776094,0.013087722,-0.007756173,-0.009343884,-0.030410359,0.031636976,0.099094674,-0.03780674,0.01188696,0.008650588,-0.055532563,-0.009018115,0.02040189,-0.07812522,-0.017572958,-0.083502516,0.069584094,0.04040405,0.09616459,-0.072117426 +2.7.11.7,"The enzyme from Dictyostelium sp. (slime moulds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. One threonine residue in each heavy chain acts as acceptor. While the enzyme from some species is activated by actin, in other cases Ca2+/calmodulin are required for activity.",384,1.0,-0.08496285,-0.057330303,0.013194542,-0.015673878,0.024857795,-0.07559834,0.04138635,0.09462036,0.025992189,-0.005696923,0.045334063,-0.003466904,-0.014818636,0.1040846,-0.02970826,0.011143929,-0.017342055,0.05599127,0.013211957,-0.034895457,0.09835583,0.026151644,-0.039289214,0.056823973,-0.019910883,-0.067534596,-0.02100292,0.03559287,-0.008049608,-0.08118092,-0.07417709,-0.0066427924,0.04153931,-0.027434183,0.005840805,0.12617598,-0.036225393,-0.04385278,0.031225739,-0.106903225,0.13089451,0.023921322,0.017207583,0.020995824,-0.04642923,-0.0021697537,-0.024501339,0.07590222,0.0036672985,0.052429132,-0.09098222,-0.047622897,0.041309647,0.037790194,-0.017167324,-0.023628732,-0.041431077,0.076309904,0.02853872,-0.040611543,-0.012491992,-0.016149083,0.020326287,0.048585583,0.014270934,-0.0058174194,-0.05322442,0.010303419,-0.021435581,-0.024054876,0.031166973,-0.04694257,0.0036802567,0.051614534,0.06205037,0.006375054,-0.100399405,-0.028633982,-0.027404306,0.005154525,0.05300684,0.0021116657,0.023054136,0.0069239973,0.013377801,0.04861043,0.045128644,-0.016709486,0.010252181,-0.04489915,0.097624935,-0.008479884,-0.0063445587,0.0024867654,-0.006797893,0.04496554,-0.006512023,0.0045557385,-0.027863314,0.017957006,0.055881303,-0.028197214,-0.028276967,-0.016086219,-0.022125324,0.04145542,-0.03563944,-0.05203905,-0.012296113,0.08528722,0.011316091,-0.033660263,0.053140078,0.028240731,-0.009646042,0.057465546,0.053141855,-0.0044191633,-0.030940093,-0.05799885,-0.03461683,-0.101255536,-0.023429148,0.000779032,-0.07391266,0.025679158,-0.13036576,5.770016e-33,-0.002820711,-0.09014452,0.0055244304,-0.004041769,0.03135834,-0.10869485,-0.0075146165,-0.027432129,-0.054180183,-0.06760693,-0.060066324,-0.046494994,0.034386486,0.041853465,-0.08667949,-0.07910806,0.061915956,-0.007962319,0.109233595,0.048187666,0.008565411,-0.014547904,-0.06767651,-0.013495892,0.036233522,0.036617905,-0.07973517,0.03149239,0.053930223,-0.026145887,0.044706173,-0.106822446,-0.09129104,0.06376639,0.0067624412,-0.012553657,-0.055436447,-0.06776686,-0.010021562,-0.06452411,-0.058499917,0.0077019897,-0.0012956103,-0.043317426,0.015949536,-0.012003089,-0.022484414,0.069073096,-0.02832819,0.064415984,0.11690053,-0.047917552,0.05852108,-0.09759827,-0.05867077,0.021921746,0.021995123,-0.034302853,0.01584265,0.06132112,0.010625228,0.018237822,-0.027752498,0.06441214,-0.028611487,0.022263767,-0.11538475,-0.07320013,0.028150946,0.03877019,-0.063238345,-0.003143524,-0.040163584,-0.07201251,0.050650567,-0.029997718,-0.0036073735,-0.02688025,-0.08092108,0.026659964,0.05665109,-0.031504944,0.0032859964,0.038990475,-0.05367994,0.0110735595,-0.04051267,0.01648718,0.0021895405,0.017315937,0.048808206,-0.05883124,-0.03745479,0.12938888,0.0023807099,-5.9064683e-33,0.0593552,-0.0798656,0.15512502,-0.00068032765,-0.052022237,0.036601044,-0.04449378,0.012210708,0.091222875,0.011283559,0.06464619,-0.04015575,-0.031752106,-0.00042743052,0.022125104,0.118099704,0.0073248837,0.034834024,-0.005995608,-0.029204484,-0.07183465,0.11303586,-0.0022307315,0.04063131,-0.009786303,-0.025101755,0.024104571,0.06478884,0.060454994,0.03389345,-0.08125623,-0.011192179,-0.083282515,-0.024609528,0.0014266575,-0.058684185,-0.04388432,-0.0063626366,0.035886176,-0.057971008,0.007644883,0.066650726,0.02122341,0.11102032,-0.034406237,0.042509068,-0.014070454,0.032556914,-0.0680484,-0.009617428,-0.0032287822,0.016343718,0.054094132,0.06775668,0.07356506,0.06805397,0.09954042,0.032587923,-0.031064548,-0.015720693,-0.013651629,-0.08425757,-0.06446855,0.0043546013,0.0638541,0.036834884,-0.14854027,-0.006583954,-0.008702728,0.01742244,0.07480778,0.023227364,-0.024636084,0.025083214,-0.059341844,-0.034447055,-0.011483557,-0.042886727,0.027077273,0.026763907,-0.040272996,0.035751425,-0.04095322,-0.06943098,0.012607728,-0.019362938,-0.005929763,0.073097005,-0.024484796,0.0881824,0.053406443,-0.0053308727,0.04781543,0.031491973,0.014379922,-3.728765e-08,0.037055075,-0.051392075,0.026897179,-0.06806255,-0.050980896,-0.036994267,0.10426145,0.058123555,0.046859615,0.033769697,-0.012952974,-0.00016185589,0.026456261,-0.034283094,0.067923754,0.08099279,-0.005722266,0.05769915,-0.02432498,-0.023654297,0.05694654,-0.08092801,-0.08580469,0.10588506,0.01500614,-0.03730092,0.07392337,0.03823846,-0.030187039,0.015269188,-0.046566483,0.008368686,-0.031508733,-0.09687966,-0.08042953,0.042133648,-0.043357763,-0.047098838,-0.037603736,0.024375305,-0.009350018,-0.06707553,0.020419901,-0.02344823,-0.061480045,-0.0055045118,0.011720715,-0.0053663324,0.075520925,0.022878239,0.046968248,0.0043479116,-0.0074074455,-0.007948864,-0.07866173,-0.010691648,0.06551158,0.015532862,-0.008466397,-0.008424184,0.036336817,0.042395253,0.16532248,-0.048755053 +2.7.11.8,"This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.",384,1.0,-0.061167076,-0.047032326,-0.06273618,-0.05124205,0.041168816,-0.018261166,0.06982136,0.09088328,0.025553701,0.04364197,-0.0030856903,0.060301427,0.0053574378,0.036562018,-0.04284521,0.10008944,-0.12266558,-0.05766024,-0.009771018,-0.036803562,0.022745287,0.033173848,-0.038842168,-0.015360788,0.05562938,0.018768042,0.03595073,-0.060114603,0.020843018,-0.034600068,-0.017702853,-0.021456469,-0.020142248,0.027628377,-0.012833167,0.10725284,0.0070103314,-0.06729688,-0.011659361,0.024732077,0.041186314,0.027622955,-0.059426732,-0.01992746,0.06032304,0.024973733,-0.04750986,0.05002007,0.03277792,0.031549558,0.010050894,-0.03562852,-0.016538277,0.00698111,0.015878681,0.08157129,0.0033647744,-0.004231878,-0.0645458,0.012761834,-0.059169658,-0.021995543,-0.014092108,0.047148854,0.12368495,-0.014212519,0.07141261,-0.06321051,-0.047991563,0.027441273,-0.005237641,-0.037339073,-0.0177789,0.050233282,-0.024507338,-0.011019816,-0.0040213224,-0.060493715,0.027364528,0.0127895,0.040350355,-0.026102467,0.124107555,0.048797198,0.018105626,0.11551566,-0.041187212,-0.004327216,0.04615273,0.07145877,-0.030001627,-0.020033907,-0.0041913204,0.018874478,-0.05582407,0.09233903,0.01540462,-0.035446495,-0.027748963,-0.038433544,-0.0035463006,0.02582899,-0.10346005,0.0018759592,-0.0480479,0.029075688,-0.028392388,0.010773465,-0.047790047,0.050979506,-0.02070101,-0.04011568,0.09917332,-0.047471944,-0.093592145,0.066837035,0.0011372506,-0.013003051,0.057173077,-0.018285284,-0.003073529,0.004589138,-0.1005931,0.09974535,-0.036553252,-0.0118133575,-0.08097929,2.7820498e-33,0.02817471,0.0021041506,-0.031629007,0.009584719,0.06733654,-0.0031021363,-0.0042514196,0.0008744282,-0.10344793,-0.068696946,0.015489932,-0.073353805,0.04088633,-0.041775443,-0.045045245,-0.017520512,0.00083155703,0.034973692,-0.0050411043,-0.10458175,0.04596231,0.008995815,-0.024938596,0.021421243,-0.01640489,0.058875002,-0.060998637,0.053321578,0.0026148665,0.021596717,-0.044067923,-0.088918805,-0.056889303,0.031145746,-0.010641179,-0.019055162,-0.047241278,-0.0037231047,-0.062420446,0.13718563,0.002008016,-0.014645,-0.08415366,0.0059870183,0.011625417,-0.13297711,0.009605404,0.06912275,-0.0109097585,0.019567432,0.06772227,-0.1168036,0.045428284,-0.0001286524,-0.037979115,0.018662892,-0.07719085,-0.14512755,0.03678916,-0.01811178,0.020321455,-0.066125125,-0.058085617,0.10191575,-0.02163481,-0.036662012,-0.057321817,-0.11987199,0.056723453,0.09442874,-0.047807764,0.008886818,0.04450075,-0.036827732,0.007144895,0.025537493,0.0015474128,0.042221695,-0.030373517,0.11181799,0.008102941,-0.05023494,0.05124549,0.032621436,0.026906269,-0.003852452,0.04447884,-0.08714469,-0.0655273,0.040766895,0.06780613,-0.039550684,-0.036068168,-0.0040043723,0.045310542,-3.564106e-33,0.034395356,-0.012303606,0.049585473,-0.073486984,-0.07405014,-0.00096719124,0.06683685,-0.028861806,0.101211764,-0.04338503,0.020647816,0.0055717453,-0.009424068,-0.024994787,-0.028186308,-0.07801997,0.017945146,0.061319284,-0.019445946,0.05212933,-0.01911635,0.062025834,-0.020984912,0.013406581,0.040871974,-0.069475554,-0.055398177,0.032874845,0.038652513,0.03329584,-0.016813966,0.010019568,0.010589427,0.050715473,-0.0072763646,0.062436923,-0.048741203,0.031442538,0.028147731,-0.01647889,0.031028243,0.026972102,-0.022071028,0.040395934,0.040457916,0.07893727,-0.037508108,0.07890982,0.008165301,-0.08893451,0.0038376867,-0.0052658236,0.037760705,0.067080885,0.046185102,-0.043009777,0.004226501,0.02665543,0.0072177737,-0.028743988,0.03259223,-0.06143854,0.019662337,0.08729309,0.13023688,0.051490895,0.03157161,0.055731162,-0.005030552,-0.021719104,0.07008683,0.105426356,-0.025656521,0.05228296,-0.036161687,-0.07294352,-0.13115501,0.0043066232,0.008159332,-0.0005764582,-0.06348132,0.026036236,-0.0630018,-0.03960187,-0.005445489,-0.015575831,-0.029856684,0.1134837,0.01584344,-0.006532201,-0.07110673,-0.033998813,-0.022151122,-0.0057467762,0.002373883,-4.0374367e-08,0.021464432,-0.006328283,-0.08340013,-0.073255666,-0.010362548,0.059047777,0.05018209,0.037157226,0.08028896,-0.037387144,-0.02979991,0.06383057,0.013934259,-0.01964883,0.05818802,-0.021168742,0.0052276035,0.017149353,0.003214822,-0.07463991,-0.03904832,-0.017616313,-0.028097082,0.050455492,0.00539565,-0.0060821655,0.06075827,0.06237997,0.0039486783,-0.06903152,-0.04830416,-0.04064403,0.069049686,-0.016874356,-0.09461154,0.056977317,0.015679605,-0.0008364276,-0.001251403,0.042089492,0.010135434,0.02505094,-0.026914151,-0.035295483,-0.047930855,0.04062477,0.11370825,-0.021052571,0.007913718,-0.030099362,0.10776761,-0.031090254,-0.01934433,-0.07039642,-0.09149079,-0.045929294,-0.009155693,-0.065611854,3.0907966e-05,-0.038932413,0.05856168,0.08065996,0.15211311,-0.056088656 +2.7.11.9,"This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.",384,0.99999994,-0.03915383,-0.030824682,-0.062794395,-0.0055037467,0.030391699,-0.0060306108,0.038141035,0.040861502,0.029300563,0.008391087,-0.006931006,0.05733008,-0.052431263,0.047600836,-0.036884688,-0.040352367,-0.050868973,0.082058184,0.0035880925,-0.0830822,0.007512996,0.021472374,0.0051273215,-0.02073739,-0.0809417,-0.04462421,0.0064655063,0.0029784418,0.015816728,-0.0026026163,-0.08594741,-0.075315125,0.0144310985,0.049632486,0.0023243285,-0.011484552,-0.053581446,-0.003995886,0.025198042,-0.03829341,0.062134013,-0.098013766,0.010282737,-0.011037286,0.055934254,0.02404012,-0.0047975183,0.04432199,0.030620841,0.09654552,-0.04365449,-0.056992903,0.017150462,0.08028022,-0.009487191,0.09601041,-0.08406344,-0.062154226,0.04498479,0.030659039,-0.033727594,-0.034473732,0.0048721,-0.014915718,0.16047634,-0.06592539,0.010327699,0.019953124,-0.06866379,0.014084208,-0.01380995,-0.044415645,0.029548163,0.06031471,0.026720135,0.09020286,-0.048599318,0.03345986,0.06547949,-0.0057852874,0.13010979,0.09146189,0.036397103,0.18340033,-0.016028147,0.027453028,-0.05111253,-0.031758398,0.027857477,0.03798191,-0.0052938657,-0.065308474,-0.021085083,-0.02064618,-0.031672735,-0.0016368857,-0.007297453,0.06314237,-0.03108989,0.04529723,-0.020138742,0.007422956,0.01134398,-0.05313905,-0.0065175076,0.026837213,-0.010723787,0.017591318,-0.010727648,0.00030276724,-0.031359967,-0.0158796,0.027536832,0.02987818,0.009150953,0.059995707,-0.009105719,-0.03421524,0.013522319,-0.083789706,-0.018278152,0.011194118,0.029358152,0.053043414,-0.007630713,0.040082026,-0.042710442,-1.9923518e-34,0.038637895,0.013971313,0.081799515,-0.02895261,-0.047890637,-0.020220133,-0.0053497986,-0.07204988,-0.029290212,-0.05878452,0.0131656155,-0.045904644,0.016827084,0.07491014,-0.044983394,-0.045270316,-0.041238733,0.02175531,-0.008640718,0.0016499088,0.042216543,0.009604769,0.008310164,-0.058462463,-0.02515877,0.02075778,-0.062336683,0.06802599,-0.0053890664,0.010452806,-0.02668426,0.062281556,0.05554912,0.03470777,0.05684479,-0.03319472,-0.049480706,-0.009493278,-0.050671477,0.09108823,0.04897734,0.034530193,-0.03798756,0.027455328,0.03514494,-0.12251895,-0.057734266,0.038486365,-0.053907882,0.005274031,0.06462839,-0.031249743,-0.0070486944,-0.056092538,-0.008852747,-0.004504375,-0.029450793,0.011729061,-0.034725606,-0.005420917,-0.009548957,-0.07889174,-0.016532812,0.033609733,-0.003944825,0.03914435,-0.09424995,-0.036041733,-0.01445223,0.04864491,0.052327197,-0.00092499837,0.05543466,0.07181974,-0.05005237,0.0059011094,-0.074566625,0.13465092,-0.112727284,0.003223335,0.003885876,-0.029913241,-0.10718516,0.054944012,-0.010530974,-0.0429623,0.083257526,-0.073970646,-0.026509818,-0.05317409,0.055883292,-0.02661516,-0.04356674,0.09771618,0.0106914155,-2.5338638e-33,0.039428234,-0.036728602,0.06606655,0.014720246,-0.087071,0.0038371922,0.052972857,0.0273608,0.022060378,0.107127234,0.039501064,-0.046091598,-0.0033943544,-0.038891353,0.08331164,-0.014934593,-0.0043911217,0.03723626,-0.015409076,-0.029588547,0.04552476,0.024456324,0.048397765,0.081100896,0.05650026,-0.026224291,-0.036862362,0.08305718,-0.092594616,0.04904973,-0.010268645,-0.017546752,0.0034802058,-0.018849147,0.021760976,-0.028444242,0.030286228,-0.05416272,0.02188216,-0.06502081,0.026612973,-0.027844558,0.047335852,0.09203232,0.014866568,0.12193857,-0.031473167,0.07990709,0.023277735,-0.05835091,0.0031667568,-0.048752278,0.059748944,0.0052206577,0.009602647,0.09988406,0.0050030407,0.03689299,-0.027046649,0.0047996426,-0.07690576,-0.013377824,-0.008565466,-0.0059268563,0.09344114,-0.055684976,-0.06041178,0.006065322,-0.0077113896,0.027215248,-0.0124648865,-0.011812343,0.037012298,-0.007546253,-0.016166,-0.053319283,-0.048107877,0.021903059,-0.010033914,-0.043865737,-0.16419148,-0.04878079,-0.03195761,-0.024538105,-0.0069571654,0.031671204,0.062147338,0.076546684,-0.012361913,0.037278306,-0.0027138314,-0.015133596,-0.12992285,-0.007030756,-0.042051047,-3.3414544e-08,0.0928302,-0.105839826,-0.044313602,-0.046551157,-0.07584039,0.0065688547,-0.036841486,0.09981506,0.030432625,0.03728735,0.0141603695,0.045730516,-0.0012103182,-0.09182575,-0.009312154,-0.010133445,0.02177891,0.021927383,-0.057017427,-0.101979256,0.009135374,-0.07440256,0.06901425,0.031727932,0.031751346,-0.029409682,-0.00520591,0.02176848,-0.15244374,-0.08196741,0.043217935,-0.04117085,-0.004344608,-0.0468045,-0.0012806513,0.114034995,-0.014302593,-0.13303624,0.043700896,0.005168579,0.014294666,0.059619896,0.005677554,-0.017800523,-0.051714715,0.0055258414,0.06293946,0.014827295,-0.004769862,-0.070815966,-0.11820652,-0.021226717,-0.012825214,-0.055674445,-0.05590746,-0.041167755,0.0017371792,-0.042082988,0.105469696,0.02414083,0.026881006,0.07830038,0.07331604,-0.0130623225 +2.7.11.10,"The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably.",384,0.99999994,0.0017631884,0.04046214,-0.04986446,-0.023635067,0.077370554,0.060054265,0.04601671,0.05529507,0.088698186,0.0052516973,-0.048907712,0.023505846,0.024758859,0.011066394,-0.016450664,0.010318449,-0.044583503,0.07285693,-0.07343712,-0.074949525,0.051054236,0.023050614,0.0042547956,-0.069606006,-0.041762263,-0.0015748916,0.020019138,-0.058870237,0.023250397,-0.05454494,0.0017111121,-0.02693127,-0.010887399,-0.008217037,0.006022458,0.053385407,-0.054302886,-0.04120078,-0.08200076,-0.055941477,0.096723646,0.0019383278,-0.048704043,-0.0015740449,0.061264977,0.04935742,-0.023039423,-0.026724843,0.07900854,0.11974576,-0.055905584,-0.03179006,0.035091545,0.08902401,0.056367803,0.040564366,-0.10170688,-0.005509116,-0.0124024,0.022033554,-0.025894787,0.019521208,0.111854814,0.013798281,0.122912526,-0.01410265,-0.020489516,-0.07605095,-0.04661447,0.0038830847,-0.06231271,-0.028761836,-0.06548467,0.029285196,-0.0042873733,0.045535408,-0.07653537,0.015185491,0.030414797,-0.013819458,0.0866919,0.0054194243,0.11645876,0.05955804,0.015819537,0.044499356,0.019016845,-0.11213405,0.048208497,0.073622525,0.06408912,-0.010503403,0.03738886,0.013704863,-0.041928288,-0.026312688,-0.049853493,0.07940628,-0.11836837,0.03366909,-0.023193378,0.0026642366,-0.024567034,-0.08999965,-0.038974527,0.017813604,-0.009221748,-0.014354171,-0.0041079456,0.078777306,-0.01258917,-0.02522371,0.014045573,-0.025807064,0.036189273,0.030975796,0.041215833,-0.07711842,-0.0016061702,-0.04189411,-0.027438046,-0.015492097,-0.010630794,0.10281135,-0.03990708,0.07069088,-0.05379926,2.2207245e-33,0.024911832,-0.005569954,0.07094116,-0.03178855,-0.021885227,-0.099402234,-0.009775072,-0.041433908,0.0040364857,-0.07200843,-0.009756297,-0.024531877,0.04621337,0.00411239,-0.019303838,-0.057810936,-0.013417545,0.029172676,0.0714686,-0.027517404,0.029521998,-0.029077228,-0.004183065,-0.002800159,-0.044386,0.04957432,0.012784818,0.029597552,-0.05855345,0.0039748196,-0.0576363,-0.05666151,-0.08157471,-0.018872071,-0.05551441,-0.053519882,-0.010143832,0.029546985,-0.06978247,0.016221402,-0.017612915,-0.030121269,-0.1668019,-0.0027469557,0.08984862,-0.12778503,-0.010836444,0.11719005,-0.026241066,-0.006252536,0.0069831153,-0.0639461,0.07752571,-0.01530821,-0.029906327,0.05377059,0.025369221,-0.039629135,0.010049548,-0.014906998,-0.017118234,-0.08780884,-0.052228615,0.12950197,0.03705447,0.07169804,-0.07185089,-0.051917225,-0.05873777,0.0072446777,-0.008850992,-0.02675536,0.1119699,0.011357499,-0.053864185,-0.035877258,-0.08091788,0.07779792,-0.03205828,0.10297275,0.0416902,-0.015683962,-0.046644874,0.036795765,-0.011055343,-0.031130742,0.069214724,-0.08897734,-0.03155843,-0.045650918,0.14248571,-0.016898744,-0.065340295,0.05696665,0.035803884,-3.3870602e-33,0.08662052,-0.017694602,-0.0010893188,-0.01715645,-0.008002033,0.03267224,0.090466835,0.06769333,0.031771854,-0.02262546,0.044364553,-0.0557973,0.011191868,-0.034253,-0.009532798,-0.06965309,0.035596676,0.11063288,0.0098016905,-0.008147209,-0.01904788,0.012244332,-0.019786408,0.035242535,-0.004121522,0.027818162,-0.010839735,0.09434211,-0.07405587,0.010962933,0.032417335,0.03524723,-0.02884574,0.0016424087,-0.023585375,0.028467067,-0.036599074,0.00079918624,0.03219513,-0.039865546,-0.0009802007,0.0154919345,0.007891908,0.028740356,0.055680856,0.06066759,-0.047739487,0.05321043,0.0023185308,-0.107373215,0.0003256193,0.034627967,-0.019020772,0.011614547,-0.037954934,0.12167219,0.047436897,0.018849773,0.011322104,0.026081575,-0.006962245,-0.01788771,0.08079143,0.06844801,0.03170446,0.0058892285,0.017936967,0.066433504,-0.0012998591,-0.0059606517,0.029380409,0.0657846,1.7646462e-05,0.0011697691,0.0051941467,-0.005928268,-0.0055923783,0.08866069,-0.0440029,0.017751234,-0.09933266,-0.024679428,-0.06257052,-0.096676186,-0.024205128,-0.011488499,-0.03106997,0.058016,0.017352846,0.01643031,-0.07068288,-0.06724608,-0.16511646,0.078808606,-0.00550468,-4.045525e-08,0.057117775,0.0026555653,-0.02234388,-0.063600816,-0.019558793,-0.010934424,-0.008750651,0.052431904,0.015645036,-0.025315598,-0.0029403083,0.04333886,-0.034327798,0.010714188,0.08744796,0.022487411,0.035067387,0.017701743,-0.009151884,-0.037089325,-0.018506601,-0.06088575,0.05498905,0.012912933,0.025893984,-0.01118373,0.045123708,-0.00034929177,-0.019595519,-0.04215202,-0.0359369,0.004483638,0.02354697,-0.008706894,-0.02015132,0.06298237,-0.027797582,-0.03515108,0.027611824,0.07533057,-0.11267334,-0.0030769617,-0.07079136,-0.021663759,0.014878346,0.07676738,0.067332245,-0.013239315,-0.052270785,-0.079472385,-0.05122685,-0.012597,-0.104430184,-0.05465867,-0.06823793,0.030715918,-0.04421461,-0.030242616,0.0848657,-0.06617849,0.047673594,-0.016029144,0.051426407,-0.032341313 +2.7.11.11,"This eukaryotic enzyme recognizes the sequence -Arg-Arg-X-Ser*/Thr*-Hpo, where * indicates the phosphorylated residue and Hpo indicates a hydrophobic residue.The inactive holoenzyme is a heterotetramer composed of two regulatory (R) subunits and two catalytic (C) subunits. Each R subunit occludes the active site of a C subunit and contains two binding sites for 3',5'-cyclic-AMP (cAMP). Binding of cAMP activates the enzyme by causing conformational changes that release two free monomeric C subunits from a dimer of the R subunits, i.e. R2C2 + 4 cAMP = R2(cAMP)4 + 2 C. Activity requires phosphorylation of a conserved Thr in the activation loop (T-loop) sequence (Thr198 in human Calpha; Thr224 in budding yeast Tpk2), installed by auto-phosphorylation or by the 3-phosphoinositide-dependent protein kinase-1 (PDPK1). Certain R2C2 combinations can be localized to particular subcellular regions by their association with diverse species of 'A Kinase-Anchoring Proteins' (AKAPs). The enzyme has been characterized from many organisms. Humans have three C units (Calpha, Cbeta, and Cgamma) encoded by the paralogous genes PRKACA, PRKACB and PRKACG, respectively, and four R subunits (R1alpha, RIbeta, RIIalpha and RIIbeta), encoded by PKRAR1A, PKRAR1B, PKRAR2A and PKRAR2B, respectively. Yeast (Saccharomyces cerevisiae) has three C subunits (Tpk1, Tpk2, and Tpk3) encoded by the paralogous genes TPK1, TPK2 and TPK3, respectively, and a single R subunit (Bcy1) encoded by the BCY1 gene. Some validated substrates of the enzyme include cAMP-response element-binding protein (CREB), phosphorylase kinase alpha subunit (PHKA), and tyrosine 3-monooxygenase (TH) in mammals; Adr1, Whi3, Nej1, and Pyk1 in yeast.",384,0.99999994,-0.04333786,-0.03012416,-0.09774004,0.023936218,0.09225321,0.020278692,0.005897732,0.0060167788,0.05347303,0.0029519098,0.017628511,0.004171685,-0.06954936,0.1258989,-0.02114746,0.05079358,-0.08227235,0.029630069,0.015438036,-0.069190174,0.036498163,0.016684595,-0.013965472,0.037795503,-0.004230407,-0.0845363,0.004453487,-0.029400155,-0.04912928,-0.009489145,-0.054982476,-0.016505975,0.045285255,-0.027388,-0.006366331,0.10647743,-0.069535546,-0.10475439,0.0046767127,-0.05094559,0.06828393,-0.005978756,-0.039803907,0.0080262665,-0.055269636,0.051934123,-0.028046701,0.017779645,-0.032290954,0.017286666,-0.009156297,-0.06295296,0.021972664,0.0024127266,-0.036777753,0.06320083,-0.02549101,0.06258429,0.043108393,-0.014092141,0.016195789,-0.04359855,0.009095552,0.011394092,0.025094666,-0.045125365,0.020489216,0.03851881,0.026412483,0.06591202,-0.05067685,0.0040107286,-0.063753754,0.0042010075,0.022240292,-0.0025853917,-0.008208903,0.015886145,0.06287523,-0.015226917,0.0047613014,0.073608704,0.089983456,0.048195474,0.022165027,-0.003535909,0.03725203,0.08070174,0.034179408,0.055602774,0.0440003,0.017845903,-0.009714161,-0.0033929637,-0.054348778,0.005242786,0.07842918,0.083815195,-0.021569693,-0.023878535,0.054967742,0.033952974,0.039693844,-0.066200085,0.038247395,0.042817604,0.027641362,0.057044555,0.018177034,0.03343355,-0.04321467,0.0144008165,0.112388395,0.014307083,-0.036217537,0.0606905,-0.0051774387,-0.045199506,0.006646792,0.057430603,-0.016654124,-0.06133053,0.030308018,0.022546312,-0.027395751,-0.021222219,-0.14009379,8.661207e-33,0.0053327125,-0.01848676,0.015460024,0.0065718303,0.051954873,-0.020884046,-0.030836606,-0.00850718,-0.07252312,0.04954742,-0.055743396,-0.083625935,0.07327433,0.03663032,-0.048142605,-0.09111341,-0.034330722,0.029685969,0.050288275,0.08795214,0.030720511,-0.004240654,-0.07571608,0.0048062466,0.0076534413,0.027621172,-0.036118537,0.008221987,-0.01595484,0.0132346805,0.025094932,-0.098413125,-0.059569005,-0.0013369472,0.044957686,-0.093169324,0.034619626,-0.029845303,-0.010814162,-0.00699235,0.06240079,0.009156731,-0.038982816,0.044851184,0.032945607,-0.05007707,-0.02060093,0.12495741,-0.00740995,0.100180715,-0.0039615743,-0.07039524,0.04057209,-0.0063409745,-0.060312863,0.012491143,-0.07194799,0.000825065,0.057605054,-0.019111153,0.008000137,0.04693411,-0.05929316,0.07279065,0.009632688,0.037209127,-0.14095981,-0.0772136,-0.025480432,0.08960725,-0.042484064,-0.06876716,0.061759192,0.009164163,-0.009841583,-0.03049004,-0.011079803,-0.023286462,-0.034801416,0.09761481,-0.062263906,-0.09307979,0.0073979674,-0.02612054,-0.07516698,-0.08700563,0.019561935,-0.03151429,-0.05728011,0.015925378,0.071967356,-0.039673842,-0.02126774,0.08789133,0.05171501,-9.559205e-33,0.1561148,-0.013219856,0.13695581,-0.09826389,-0.054777056,0.08409962,-0.0022222293,-0.12287075,-0.0031477124,-0.065376386,0.0705919,0.020343047,-0.010001865,0.04075516,0.033097573,-0.0040562665,-0.028307535,0.10118309,-0.01909741,0.05805614,-0.042242903,-0.0148414895,-0.06550641,0.035003446,0.0035575682,0.009015963,0.006156914,0.086189866,-0.037278175,0.0974996,-0.051386826,-0.024450498,-0.033736113,-0.015075148,-0.04311245,-0.0035474305,-0.029599715,-0.0476966,0.020924635,-2.7335656e-05,0.042818967,-0.028233357,-0.038722266,0.02716525,-0.012198053,0.12445483,-0.050074797,0.052067947,-0.05607222,-0.0651765,-0.008072356,0.006637849,-0.05718948,0.056435004,6.0132636e-05,0.04426961,0.033178147,-0.0033656356,-0.015942158,-0.015553833,-0.001605442,-0.00026103214,0.040830884,0.05973755,0.0052626496,-0.0066185757,-0.036913212,0.06446317,0.023722589,-0.007205895,-0.029589167,0.06245816,0.022347733,6.1823407e-06,0.006422059,0.0007127311,-0.09369836,-0.05406732,-0.0104989335,-0.098805614,-0.052389104,0.012422986,-0.04399576,-0.09275808,-0.03213886,-0.025047733,0.024728404,0.09460684,-0.028548868,0.026404116,0.033005796,-0.056077316,-0.066782564,0.080511294,0.0881268,-6.6289594e-08,-0.029054202,-0.031420257,-0.024710337,-0.08748766,-0.014575233,-0.0074119437,0.04042095,0.023034805,0.02847676,0.048869796,0.025253968,0.010722679,-0.022320552,0.020570055,0.091301456,-0.025542147,-0.035208955,0.041403882,-0.02814318,-0.008747669,-0.03433945,-0.084690206,-0.027526438,0.07292609,0.01354385,-0.07908871,0.060547955,0.125862,-0.0024223537,-0.08959108,0.005003319,0.037888367,-0.05384085,-0.0057738,-0.046870675,0.07537088,-0.08009664,-0.04758537,-0.0774375,0.03105791,-0.02678544,-0.030922823,-0.060663793,-0.035532728,-0.021224605,0.023445463,0.10606494,0.029724224,-0.034616526,-0.06650061,0.046808615,0.013950672,-0.068534724,-0.022437733,-0.035799313,0.032446925,-0.026344188,-0.039544355,-0.0124641545,-0.038409337,-0.00603401,0.017953878,0.08244404,-0.16288023 +2.7.11.12,CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates [3]. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4].,384,1.0,-0.04418309,-0.00936782,-0.038576707,-0.053024687,0.033180095,0.030310353,-0.041198414,0.068145074,0.0425263,-0.006484866,-0.029986952,-0.029922567,-0.050327,0.07612065,-0.0027063843,0.04105452,-0.055663098,0.04142017,0.07919565,-0.06503187,0.02417099,-0.025171693,-0.0276871,-0.005867745,-0.046266414,0.010401381,0.06385516,-0.021160351,-0.012419832,0.014995767,-0.13338895,-0.020495314,0.03063312,0.030265383,0.018823517,0.13315195,-0.08796346,-0.09920165,0.012148314,-0.087254114,0.07379271,0.016405463,-0.044757932,0.02214807,-0.0051360093,0.06454474,0.041642375,0.09059556,0.0066525345,-0.0058329096,0.018543515,-0.03377834,0.022263797,0.013603615,-0.072222754,0.04686242,-0.049568903,-0.009484521,0.0738425,-0.041985538,-0.04536075,-0.047023192,0.019387975,0.021498239,0.13136286,-0.09447047,0.04284977,-0.0050740475,-0.009498851,0.026190374,-0.07664903,-0.035014,0.010080848,0.047161993,0.037236508,0.0015367344,-0.0051697637,-0.03938725,0.04157719,-0.03371871,0.0709322,0.06920014,0.044527758,0.096380726,0.03999934,-0.033768512,-0.01271958,-0.014176415,0.040693797,0.020879667,0.024311205,-0.060500957,-0.096516825,-0.028399201,-0.08626943,0.0011765838,-0.020170983,-0.008079285,-0.03860719,-0.03681956,0.03828599,0.037084904,0.06097811,-0.03963404,0.027460197,-0.00042828987,0.0058055934,0.035474908,0.03375822,0.008016915,-0.0085436525,0.03750963,0.044868402,-0.030641379,0.0778895,0.08527875,-0.011853503,-0.056907307,-0.00432768,0.020266388,-0.08049235,-0.08453114,-0.017742824,0.053996198,-0.08323567,0.02810025,-0.121943556,2.1585605e-33,0.022625934,0.008374086,0.03591528,-0.080125846,0.024236698,-0.009621653,-0.009317219,-0.040032394,-0.08919741,-0.08096786,-0.053969815,-0.103042245,0.06410676,0.05213681,-0.032370456,-0.068647146,-0.012006358,0.07980977,0.06947231,-0.058875035,-0.02696716,0.032187607,-0.0011418329,-0.0066780075,0.027942616,0.05375162,-0.09868199,0.06946107,0.011130649,0.012262872,0.013243029,0.030753495,-0.122850716,0.0453129,0.08723686,0.03758461,0.030032555,-0.08512838,-0.0013488644,0.005921733,-0.019154185,-0.0143581005,-0.019112986,-0.01697501,0.014070785,-0.046584975,-0.089589044,0.05274361,-0.019748524,-0.005071873,0.09010141,-0.016371433,0.07045218,-0.083956316,-0.036646597,0.030547261,-0.06520025,-0.07418045,0.025438624,-0.0045198123,0.023569303,-0.017817337,-0.07445082,0.06073684,0.05085707,0.0710421,-0.07900287,-0.08740495,0.05071201,0.12090713,-0.026200943,-0.0008072971,0.042297825,0.05511984,-0.026576769,0.011895397,-0.04266971,0.07231879,-0.013621747,0.1253038,-0.064928405,-0.009513202,-0.054203298,-0.0165583,-0.001830527,-0.043899886,0.079012156,-0.055395667,0.0025017674,-0.0150134815,0.07132208,-0.023502493,0.018231016,0.08199771,-0.043753628,-4.9376537e-33,0.052271944,-0.048267525,0.02409609,-0.0496509,-0.09058838,0.032944486,0.010018301,-0.098217204,-0.0062746922,-0.02604156,0.074657336,-0.0653837,-0.0459345,-0.0076141567,0.046269547,0.02251155,-0.04519092,0.1259639,-0.055473536,-0.005288381,0.041753702,0.008879186,-0.009940996,0.114848904,-0.0103643015,-0.027439984,-0.0692268,0.07381503,-0.0021008884,0.022914657,-0.04581718,0.060866825,-0.08910914,0.0123361675,0.039538745,0.029538505,-0.09815617,0.03220136,0.067874216,0.014376073,0.11550127,0.09684708,-0.019351486,0.06333761,0.033100374,0.037158214,0.009780063,0.052046783,-0.036824398,-0.10789583,-0.011019306,0.009236846,0.04201957,-0.023210324,-0.00745865,0.12876962,-0.031148486,0.023121001,0.024459686,-0.06532951,-0.08850796,-0.05504598,0.04278915,0.060665563,0.085425355,-0.0043864916,-0.0072811963,0.014192219,-0.0060264235,0.001416203,-0.018131945,0.052004058,0.058340877,0.02919838,-0.057838548,-0.00026834247,-0.042263698,0.004820834,-0.0037884947,-0.046118006,0.005045623,0.025170745,0.011969207,-0.035267703,-0.020018809,-0.01775909,0.0201554,0.07548442,0.07277037,0.0045883157,0.0021950868,-0.017920218,-0.039543577,0.019782817,0.05983009,-4.424551e-08,0.030269997,0.036257163,0.016134806,-0.0427939,-0.004500591,0.062347006,-0.037367832,-0.052633148,0.033913035,-0.006292258,-0.031940658,0.07349465,-0.027430445,-0.038636964,-0.0061770207,0.0018058383,-0.030459512,0.020016454,-0.00097997,-0.017809037,-0.12835158,-0.032496154,-0.03320026,0.06678463,0.07467294,-0.06765414,-0.0031877554,0.06350399,0.010041327,-0.015121772,-0.0053014318,0.011042655,-0.02203716,-0.01553721,0.022630628,0.04728358,-0.06520297,-0.06972064,-0.027939824,0.04518602,0.016252026,-0.051023617,0.024854664,-0.023795547,-0.078275345,0.03286936,0.047635328,0.00060401286,-0.090679705,-0.03984851,-0.034469415,-0.0043587442,-0.028188726,-0.042167876,-0.0031957866,-0.060990117,-0.050493315,-0.068699546,-0.024877021,-0.065950036,-0.012666482,0.058090862,0.0715191,-0.08303216 +2.7.11.13,"A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters.",384,1.0,-0.09791283,-0.04750512,-0.078470975,-0.024922494,0.040683042,0.026889816,0.029225783,0.038706437,0.10270074,-0.0548636,-0.0018318585,-0.057532616,-0.015587407,-0.00080830196,0.044772636,0.028236868,-0.10259092,0.046343453,-0.006116225,-0.029028941,0.0006824103,0.0066530844,0.03179676,0.048288003,-0.07605439,-0.0065968623,0.07031204,0.045526005,-0.08757581,-0.002111886,-0.011636327,-0.079365574,0.046138544,0.025570115,0.024955463,0.07815468,-0.062442794,-0.020007659,-0.010064551,-0.017926337,0.07139419,-0.029580912,-0.017223248,0.037312713,0.022633994,-0.019535778,-0.049776115,0.027411409,0.047088612,0.063967824,-0.029493207,-0.061544117,-0.032969642,0.03411643,0.0040877513,0.010093384,-0.115906395,0.01065595,0.0915669,-0.012477962,-0.0009918616,-0.026828721,0.060865868,0.010044842,-0.014937005,-0.06600659,-0.01751032,0.010672217,0.004815262,-0.01340416,-0.08136707,-0.056802586,0.016668713,0.083729155,-0.04805553,0.018704252,-0.013206289,0.051487677,0.015630066,-0.1280921,0.077708595,-0.040229052,0.020101607,0.08500345,0.0013560355,-0.006771244,-0.014877297,-0.056552567,0.059231438,0.068089016,0.06374918,-0.08885022,0.027820235,8.594067e-06,-0.08837509,-0.02739827,0.04697461,-0.0044050487,-0.03351265,0.007345174,0.015027738,-0.0018023291,0.020637695,-0.05435621,-0.017382614,-0.0076501537,-0.045939222,-0.018695297,-0.08151553,0.02477711,-0.04681367,-0.03111207,0.038301617,-0.024424132,-0.011221346,0.054859262,-0.021477453,-0.045875862,0.0036074743,-0.052285925,-0.040160168,-0.05104037,0.026069935,0.021057317,-0.0015156501,0.0031593367,-0.13296142,1.1788163e-33,0.02348239,0.03990648,0.04400864,-0.021724334,-0.009056201,-0.068430364,-0.0095799845,0.02621037,-0.02278696,-0.09098746,-0.01299872,-0.08465116,0.015556457,0.05947788,-0.0017547725,-0.03450139,0.001081253,0.06941642,0.07554296,-0.05444972,-0.059829686,0.044421136,-0.0017476282,-0.02738592,-0.023876322,0.029597713,-0.06423333,0.029090568,-0.00082539837,0.00884427,0.008286459,-0.0021805824,0.048600968,0.009310505,0.10212143,0.027108746,-0.027297955,-0.027646441,0.030076798,0.051750578,-0.034669988,-0.041600134,-0.06463426,0.018251294,-0.03583593,-0.030498864,-0.10090769,0.054464504,0.024216492,-0.033462863,-0.001988097,-0.07178375,0.03257201,0.03640501,-0.006434671,-0.013432048,-0.11789554,-0.02608552,-0.024093352,0.008694632,0.012898385,0.0044436096,-0.03373627,0.07002585,0.0024666716,0.008305581,-0.121102884,-0.04081518,-0.0138586275,0.110621214,0.022070933,0.008150869,0.116595775,-0.010859558,-0.0056286664,0.047342457,-0.04740404,0.08413164,-0.07888733,0.09598559,-0.024603317,-0.04510968,-0.027026052,0.019713799,-0.05028103,-0.03780006,0.031671762,-0.060359918,-0.07508126,0.047018897,-0.08122839,-0.049321067,-0.0071147224,0.072975345,0.022448033,-4.9553537e-33,0.038670022,0.022122385,0.11969736,-0.0473676,-0.014279527,0.065207124,0.023319244,-0.09574544,0.012502964,0.060427967,-0.012062422,-0.008668141,0.06450471,-0.049499672,-0.023646336,0.03210817,-0.031871554,0.081503555,-0.05191702,-0.060386464,-0.031681024,-0.0041897343,-0.07478176,0.10002726,-0.008617961,0.016738625,-0.08562024,0.10761397,-0.113631554,0.08192399,-0.022367988,0.031814933,-0.0017847214,-0.02707428,0.027386686,0.050067965,-0.028389463,-0.009919697,-0.038038727,0.030071542,-0.017287971,0.023295688,0.06017066,0.014188554,0.019021273,0.051029857,0.10128555,0.076650955,-0.0003981067,-0.049655084,0.00074673654,0.0006541917,0.024390047,0.0756816,0.0066438983,0.14582205,0.0052864454,0.03675346,-0.02734782,-0.034604166,-0.052364185,-0.084448315,0.026179554,0.036331393,0.06883757,-0.03637227,-0.035377406,-0.035908714,0.0648745,0.04263891,-0.0010716794,0.0015274306,0.011929906,0.0638811,-0.06363554,0.0008447886,-0.031332593,-0.043840867,-0.035124626,0.016789075,-0.043792684,-0.020127945,0.06577869,-0.1093526,-0.03667412,0.0828583,0.009396921,0.015654644,-0.030665183,0.025967946,0.007196929,-0.044993743,-0.06622944,0.096608356,-0.010498622,-4.095822e-08,0.02386805,-0.0926336,0.0029353981,-0.07781233,0.0069823884,-0.02384379,0.002117194,0.021092694,-0.017896451,0.017686946,0.018388236,0.0701883,0.0013018969,-0.05208257,0.045820404,0.0027100882,0.020162558,0.061841905,-0.048231367,-0.0643374,0.044142053,-0.06604808,-0.0021750114,0.04742115,0.03240144,-0.094391555,0.028339341,0.07995785,-0.014656183,0.047932774,0.03618473,-0.041735217,-0.01654765,-0.059666548,0.07359363,0.0448891,-0.029881056,-0.1293044,-0.017663239,0.1429626,0.034675173,-0.026890261,-0.08243749,0.05729083,0.0047201286,0.043204132,0.042024277,-0.016003292,-0.06010525,0.011395902,-0.07376096,0.06660207,-0.03049468,-0.03698256,-0.049514513,0.0063929935,-0.085114524,0.033596046,0.009120454,-0.03455231,0.05166095,0.060891952,0.17650299,-0.027127866 +2.7.11.14,"Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).",384,1.0,-0.11471967,0.016612852,-0.059622955,0.0456417,0.079492055,0.03735591,-0.03505216,0.050629947,0.032219533,-0.03522963,-0.008361039,0.010587602,-0.031070594,0.11170114,-0.01674207,0.019839559,-0.024988914,0.02667648,0.049850214,0.015705137,-0.033383787,0.02589769,0.010481909,0.012858696,-0.0474919,-0.013349579,0.062346287,0.011476728,-0.039370574,0.022334298,-0.037764598,-0.08832735,0.060534567,0.039481066,-0.052670687,0.12696014,-0.030712135,-0.060850862,-0.047754224,0.021737538,0.06720716,-0.0010263275,0.017226966,-0.0165185,0.07422737,0.062847786,-0.052923698,0.054855365,-0.061150007,0.033245247,0.017323105,-0.046156626,0.030205894,0.12880522,0.042579237,0.063414656,-0.13570075,0.053421106,0.0080306465,-0.023238596,-0.04658991,-0.028897338,-0.011844272,-0.005805075,0.025917547,0.0040493384,0.030122936,-0.053906,-0.0019653684,-0.010888192,0.04451848,0.024892189,0.03961292,-0.005427081,-0.087503545,0.05024294,-0.07647545,0.021967933,0.015567046,-0.084754,0.124588065,0.01153267,0.030702095,0.07210965,-0.008172159,-0.0036773642,-0.012242741,-0.032704867,-0.08892751,0.041132,0.09955231,-0.05301744,-0.012733239,-0.022221286,-0.125812,-0.026195318,-0.026553698,0.039058346,-0.103723064,0.012576108,-0.02247946,0.028045826,0.019230317,-0.019895319,-0.0048365286,0.03086441,-0.015790978,-0.00039578663,-0.017446164,0.004897071,-0.013912626,0.02232699,0.048258822,0.004364781,0.018946532,0.07562975,-0.049452227,-0.009584941,-0.008843577,0.045891806,0.027231546,-0.029678246,-0.09920561,-0.0023730185,-0.035524104,0.07181242,-0.08681823,2.5891446e-33,0.013747468,-0.023128852,0.013755459,-0.049861357,0.027904911,0.0076175244,-0.0694874,-0.0006223274,0.0703558,-0.09299406,-0.04406881,-0.036262386,0.039524306,0.09212978,-0.046668395,0.033053868,0.0017130603,-0.007069687,0.08194719,-0.061308548,0.05681802,-0.0019458726,-0.063280925,-0.01571501,-0.016265763,0.044046957,-0.07082396,-0.00679789,-0.010452169,-0.013244088,0.03584583,0.0075596767,-0.034642376,0.07746261,0.000647222,0.0085168835,-0.0010874259,-0.09778936,0.049710922,-0.03473022,0.018703988,-0.014912945,-0.09936256,0.052584965,0.066356845,-0.029913545,-0.0467303,-0.034043677,-0.015421318,0.029470047,0.11368069,-0.023651773,-0.045110993,0.014602935,-0.054873224,0.006418709,-0.049396094,-0.11630953,0.01101719,0.011805635,0.03386427,0.039007034,0.034842044,0.011325613,0.00827273,0.050419953,-0.08844181,-0.16070132,-0.12863125,0.0036085555,0.004313661,0.027131295,0.11197649,-0.012891597,-0.0651658,-0.05708944,0.016601093,0.006981179,-0.035573825,0.054134123,-0.04056555,-0.029520115,-0.014808192,0.070957184,-0.039481416,-0.049583014,0.08534806,-0.07654716,0.0021145362,-0.028025223,-0.006706248,-0.060630642,-0.06869627,0.02981358,0.029976325,-4.0618682e-33,0.05466313,0.014265723,0.056580674,-9.893513e-05,0.012581123,0.05272824,0.0049530948,-0.11752489,0.04231517,-0.052055042,0.016122501,0.016707456,0.043514445,0.03596742,0.056491766,0.023864929,-0.07461418,0.040666047,-0.03760108,-0.056909878,0.042861838,0.013946168,0.013706727,0.08880267,0.05325339,-0.07265924,0.012117562,0.04055755,0.030519262,0.09172957,-0.067450285,0.04081716,-0.09041754,-0.05848083,0.024922494,0.022358906,-0.04205456,0.013385041,-0.04948659,-0.05030326,0.04081895,0.012641839,-0.020667944,0.03998647,0.05402048,0.10019737,0.060600862,0.04529548,-0.046585526,-0.07049732,0.019452365,0.045242295,-0.053117774,0.06525312,0.028070418,0.077972844,-0.045827854,0.026639186,-0.049668618,-0.004512734,-0.052118797,-0.029373998,-0.00049155037,0.0077082855,0.05777461,-0.0034214058,0.08775206,0.041206762,0.11254262,0.021713307,0.058880646,0.033269927,0.15143539,0.07896471,-0.070483275,-0.022846328,-0.071932495,-0.009661287,-0.022212747,-0.09258765,-0.016692216,0.030600859,0.016266916,0.02269076,-0.06376984,0.057366904,0.0011236412,0.067235254,-0.028705334,0.00028695265,-0.0013745246,0.030220343,-0.02359157,0.040376864,-0.0077390084,-4.7967745e-08,0.08803181,-0.03713604,0.050400425,-0.086497605,-0.0025829158,-0.017225675,0.09887727,0.03165992,-0.046894513,0.0063698506,0.0006561199,0.047265556,0.022825602,-0.056869034,-0.019451678,0.0127744,-0.003997632,0.028162934,-0.046841618,0.021533081,-0.022598889,-0.04350705,-0.03009845,0.017068729,0.04135311,-0.0736363,0.039862312,0.0687951,-0.037687093,-0.0023734162,0.13169572,0.0060071065,0.02106107,-0.014006991,0.0073578893,0.019782344,0.015257664,-0.011403774,-0.0017007319,-0.032256987,-0.09290793,0.007999997,0.038890414,0.01626746,-0.082040265,-0.0988085,0.11165762,-0.07794966,0.043026194,0.035495706,-0.03974588,0.027399803,-0.07010513,-0.07649028,-0.042525318,-0.0132522145,-0.03964909,-0.02577022,0.012842097,-0.03760225,0.02764269,-0.020002574,0.054558203,0.012583054 +2.7.11.15,"Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).",384,1.0,-0.09919144,0.010495854,-0.081985205,-0.008766695,0.05967627,0.0014671023,-0.042569946,0.045787547,0.038424797,-0.036247883,-0.0020312523,0.030410014,-0.003565455,0.095242254,-0.0031639335,0.021305881,0.00027673793,0.00061338587,0.021683825,-0.009945704,-0.02375088,-0.0016908774,-0.013108636,-0.013123264,-0.04796694,-0.038108215,0.0938987,0.008387162,-0.035251785,-0.0060891467,-0.064088084,-0.055662997,0.039010778,0.037651427,-0.0519391,0.16926053,-0.04127182,-0.034396645,-0.034753557,-0.010109404,0.05797724,0.0090268105,0.046322633,-0.028752241,0.035562284,0.03512306,-0.038458027,0.025840718,-0.08525032,0.034311168,0.015940538,-0.072365366,0.0015361565,0.11793355,0.044172756,0.029338587,-0.115867585,0.07103467,-0.003675514,-0.05245432,-0.0058383383,-0.06724438,0.006744081,0.0084951045,0.012519391,-0.0097927945,0.047313407,-0.054560296,-0.011489685,-0.017468572,0.025273701,-0.004365072,0.038083814,-0.00439642,-0.071973294,0.01791152,-0.067759916,0.023872796,0.08655381,-0.09743874,0.093368694,0.031480346,0.053858902,0.09307745,0.0034507804,0.02347286,0.0014290966,-0.0057445713,-0.10880923,0.008102317,0.11121624,-0.06268039,0.0006733822,-0.023968231,-0.13287418,0.005857369,-0.034368195,0.029804343,-0.087735675,0.017682616,0.020879632,0.057069913,0.010552506,-0.022642111,-0.029698068,0.032368716,-0.027042475,0.022815777,-0.06606838,0.004916216,-0.024021799,0.052278467,0.05136441,0.020546375,-0.019042518,0.07783219,0.013609909,-0.008525063,-0.005560731,0.052490905,0.018119667,-0.030051246,-0.05803854,0.029284062,-0.02570872,0.08341542,-0.07021288,1.9228738e-33,-0.007027029,-0.04962855,2.0867206e-05,-0.09162162,0.009960284,-0.011466726,-0.05620094,0.02715728,0.025415465,-0.09299827,-0.032505143,-0.032786127,0.052907392,0.03966257,-0.06933617,0.056776877,-0.02948989,-0.023083929,0.046165273,-0.05403639,0.04648643,-0.021656202,-0.058655255,0.016832436,-0.02225243,0.07495253,-0.050050505,-0.0077225426,-0.022605347,-0.0068519246,0.0013396804,-0.0041555814,-0.058946192,0.09896404,0.03579119,-0.0029517976,0.03209362,-0.07379082,0.059044402,-0.016442128,-0.012425351,-0.019159168,-0.07073607,-0.010739821,0.07089316,-0.029501766,-0.033867106,0.030327855,-0.004434699,0.020022186,0.122176155,-0.051288538,-0.031994786,0.0026428152,-0.07671249,0.0012105468,-0.030443083,-0.09364933,0.012407074,0.0016671438,0.046599463,0.031848084,0.054552294,0.044140607,-0.011371532,0.064186126,-0.11600409,-0.14985044,-0.071763836,0.07793645,0.002695946,0.016068978,0.092329055,0.0024758712,-0.057328925,-0.046518605,0.024398783,-0.011887243,0.00244997,0.13507614,-0.01705822,-0.02877339,-0.007527075,0.011644347,-0.058637086,-0.07779411,0.020756261,-0.11507792,-0.008178768,-0.006010542,-0.013611207,-0.02439872,-0.07227968,0.040707573,0.03339661,-3.986472e-33,0.06986321,0.014260006,0.07574095,-0.005007206,0.026794538,0.053876553,0.022888342,-0.10485637,0.061053112,-0.053609055,0.035611756,0.013683103,0.06545894,0.07539968,0.0785505,0.035342157,-0.09679474,0.02715904,-0.017616544,-0.07383399,0.012296923,0.002581257,0.011733363,0.07890577,0.058383856,-0.036913346,-0.05458735,0.0596837,0.017057134,0.10470162,-0.0485227,-0.012142986,-0.08393496,-0.040008284,0.023487356,0.018872714,-0.041511144,0.042312715,-0.04883015,-0.057451073,0.02616053,0.019592132,0.033125043,0.08452794,0.033559896,0.09339854,0.067862354,0.071462154,-0.036103867,-0.06928201,0.015845977,0.06913585,-0.055247903,0.05775701,0.00040410785,0.123091,0.01045491,0.022409707,-0.081563264,0.0071994793,-0.08529635,-0.05850102,0.007942608,0.019993931,0.041434094,0.0030585728,0.05955604,0.03907913,0.111245885,0.037235748,0.0744209,0.026477436,0.09400565,0.031090211,-0.07485594,0.014482323,-0.048889197,-0.020905662,-0.026494943,-0.098386936,-0.01557039,0.04915133,0.000640388,0.011326249,-0.056424532,0.013484459,-0.034677677,0.053710204,0.0044481475,0.021509046,-0.02243444,0.021323146,-0.07301492,0.023082051,-0.0009863237,-4.8334886e-08,0.06835901,-0.04841959,0.042490084,-0.08876446,0.030713998,-0.0007144042,0.06579415,-0.0015351644,-0.028391365,0.022117762,0.010053244,0.049786616,-0.016477147,-0.042087372,-0.01131127,0.018986512,-0.0005958116,0.038328275,-0.05251459,-0.004063361,-0.012909264,-0.07373798,-0.06446053,0.029749732,0.0020281298,-0.04391294,0.00694205,0.063308075,-0.028579172,-0.0097731585,0.10017732,0.01917358,0.02263283,5.954493e-05,-0.02868222,0.047376618,0.004917243,-0.003948773,-0.025086457,-0.04317941,-0.0475301,0.019227616,0.012685692,0.010828462,-0.11196994,-0.094227634,0.096176736,-0.09341047,0.015018822,0.087918,-0.024612619,-0.0010353178,-0.05249066,-0.06889376,-0.02631051,-0.014406338,-0.014699622,-0.061033934,0.017132271,-0.035423126,-0.010405875,0.0008532346,0.10403291,-0.02457693 +2.7.11.16,"Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, beta-adrenergic-receptor kinase).",384,1.0,-0.100389004,-0.0014318943,-0.08145561,0.004939666,0.08339414,-0.009044787,-0.0089624375,0.03250117,0.058158696,-0.019804819,-0.02466798,-0.015350623,-0.04424988,0.05885834,0.017144026,0.0070786746,-0.036909122,-0.020146688,0.03620955,0.00172448,-0.02589531,-0.01831619,-0.020466436,0.05460864,-0.037093814,-0.021725168,0.0789315,0.008378132,-0.041478477,-0.013438014,-0.05773238,-0.100375466,0.048410743,0.022208871,-0.032603726,0.17568952,-0.056420065,-0.07867954,-0.034024425,0.0136209335,0.06380261,-0.014886477,0.019184565,-0.02979164,0.043342955,0.03095089,-0.013115453,0.040964063,0.030184446,-0.011239686,0.04146564,-0.06448463,-0.009675032,0.041764844,0.0022483622,0.038936313,-0.10570693,0.05905947,0.016468005,0.030035473,-0.03867655,-0.012298743,-0.019784685,0.009449107,1.1888411e-05,0.0059462492,0.04564548,-0.050868217,0.022757817,0.025579423,-0.04135358,0.0008799817,0.042969014,0.027025888,-0.06336739,0.06948624,-0.057492673,0.06986695,0.090236515,-0.08566969,0.056733325,0.006010572,0.00700807,0.054990802,-0.00057171506,-0.031185405,-0.01154378,-0.010213569,-0.01573217,0.002868583,0.08732999,-0.065468326,0.013122082,-0.019564744,-0.09989433,0.028443951,-0.036417678,0.015498265,-0.05492251,-0.023192346,-0.04047062,0.076075636,0.024597496,0.037287887,-0.025893724,-0.011712484,-0.0152592305,0.033449374,-0.022925386,-0.029816438,-0.051525235,0.03162158,0.095432326,0.060654588,0.044312805,0.068311304,-0.08631163,-0.06462915,0.025159242,0.019535782,-0.0026532651,-0.045536052,-0.07350703,0.02352388,-0.015039399,0.070189066,-0.072069526,1.0050191e-33,0.054166026,0.015697692,0.07739933,-0.043056972,-0.00792803,0.0021127493,-0.057435084,-0.014803547,-0.02964016,-0.026239607,-0.006676745,-0.029053068,0.044709872,0.079048984,-0.0552353,0.062185496,-0.027373558,0.017158646,0.08834781,-0.04377677,0.0050631426,0.03441339,-0.058197323,-0.017497597,-0.007876294,0.086978234,-0.1177405,0.007565725,-0.010195649,0.0084584635,-0.004440046,-0.038164075,-0.06655811,0.07819574,-0.037482515,-0.06844445,0.0065507493,-0.088854745,0.031549253,-0.019407619,0.008183784,-0.02506573,-0.048893385,0.02629388,0.07247273,-0.030296208,-0.031439822,0.005907195,-0.011422552,0.07028647,0.059386894,-0.0235092,0.01877938,-0.0017572884,-0.07714887,0.004864327,-0.08148296,-0.07348314,0.034359608,-0.002742723,0.04537339,0.07230207,0.022354335,0.009840964,0.055303838,0.061560307,-0.0873464,-0.13765757,-0.06560891,0.12109537,0.036070857,0.0017212625,0.077320166,-0.017429573,-0.05914468,-0.053566363,0.017252957,-0.0027166342,-0.047556184,0.09632484,-0.04641088,-0.017338483,0.018421844,0.04443453,-0.06856312,-0.070514746,0.09740754,-0.08472319,-0.0006610126,0.0073809796,-0.040731817,-0.029035995,-0.048051592,0.06737164,0.0097882375,-2.8192944e-33,0.115365334,-0.014358932,0.077954546,-0.0695916,-0.05713411,0.072450824,0.073119506,-0.114066005,0.09661836,0.02210404,0.05459254,0.03553623,0.06140382,0.020472547,0.057746388,0.025370078,-0.11932355,0.020964192,-0.0012850916,-0.064724304,0.034818433,0.061210558,-0.005695109,0.10325108,0.081430085,-0.081692584,-0.0040619676,0.050838277,-0.062227935,0.050222848,-0.045151934,0.029655868,-0.037840243,-0.021000152,0.009380266,-0.044099376,-0.07505592,0.0046722125,-0.03415783,-0.026333634,0.012062283,0.06051581,0.0661771,0.025598338,0.054387618,0.086058386,0.08297005,0.09539666,-0.004186167,-0.065819286,-0.024145273,0.006131177,-0.063182876,0.041417316,0.002509493,0.082374595,-0.06083267,0.055081643,-0.051328436,-0.03875311,-0.06820481,-0.071768805,-0.022246333,0.041260444,0.09993934,0.02885243,0.06649999,0.016071754,0.06763033,0.059343148,0.068400405,0.0002600353,0.101603866,0.08109864,-0.031784996,0.018010167,-0.05319104,-0.006009846,-0.020422406,-0.078903235,0.0018277046,0.06148779,-0.023683952,-0.023611365,-0.03769017,0.036434393,-0.0415067,0.0954239,0.03803349,0.017861644,-0.015559325,-0.034874655,-0.057113186,0.024987431,0.009705464,-4.4491852e-08,0.07611191,0.034597393,0.002971263,-0.075744756,-0.010336924,-0.0046108305,0.056780037,0.013414766,-0.043551683,0.036490608,0.041983444,0.0036467805,0.012851033,-0.014684728,-0.0025731898,-0.000731272,-0.037356686,0.03391418,-0.024884986,-0.012961313,0.010893426,-0.08907251,-0.036424614,0.033618063,0.05112534,-0.076841325,0.040963523,0.035479806,-0.029147074,0.024799118,0.07849034,-0.02380233,-0.0049496302,-0.0047677257,0.0700954,0.04841794,-0.07969511,0.016823646,-0.004345532,0.02301296,-0.07345305,-0.05398284,0.03342625,-0.040745094,-0.08637295,0.013493124,0.077997625,-0.06265727,0.004971217,0.029282218,-0.04127777,-0.016241765,-0.06327854,-0.077580996,-0.04506563,-0.028949395,-0.08492834,-0.04925478,0.020082248,-0.09284108,0.02984343,0.03678271,0.05274271,-0.026667494 +2.7.11.17,"Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).",384,1.0,-0.051732544,-0.08036882,-0.009163314,0.020821288,0.07338206,-0.02329929,0.021372272,0.071714446,0.05683944,-0.048831742,0.04439779,-0.0064825634,-0.042989545,0.038577434,0.036785737,0.05771388,-0.031041423,0.022216914,0.028858487,-0.06252393,-0.057103768,0.020249981,-0.030669944,0.004371549,-0.10043452,-0.022121245,-0.019916914,0.055950362,0.049325887,-0.06318283,-0.055540547,-0.08120795,-0.04471371,-0.024328949,-0.0376903,0.04455958,-0.07680959,-0.09577263,-0.058649406,-0.08214701,0.1247854,-0.0055936784,0.063128464,-0.06772509,0.035429828,-0.0286509,0.043970898,-0.018456321,0.028853329,-0.007200158,-0.039921485,-0.028737655,0.003297487,0.053036712,0.021599445,0.117790006,-0.14732037,-0.06375928,0.06913227,-0.0076164505,-0.049253255,-0.009222485,0.02051762,-0.046813354,0.04227252,0.0025645683,-0.035030592,0.024270931,0.019083308,0.045191556,-0.011329045,-0.026090885,0.04310675,0.092041366,0.043768406,0.05867671,-0.1029721,0.023788312,0.039315592,-0.02486289,-0.013201675,-0.06772624,-0.04646267,0.026248114,0.09292924,0.0018359121,0.06333574,0.014166968,-0.033419676,0.02300766,0.08406484,-0.020624375,0.0156837,-0.061707463,0.04983736,0.009911995,0.067762725,0.023176298,-0.07508754,-0.021014187,-0.022375882,0.031431496,0.004140224,-0.024917422,0.013979614,0.0197968,-0.019073296,0.02658869,0.025290338,-0.017816646,-0.007186983,-0.062291726,0.056495704,0.0031571367,0.08381436,0.07015192,-0.0070757065,-0.056118097,0.038116362,0.017363876,-0.0040856507,-0.017355066,-0.007908344,-0.0067802607,-0.09612345,0.07426642,-0.09273708,1.0126179e-33,0.023779612,-0.020675747,0.012253115,0.02466245,-0.0040081497,-0.04969587,-0.08039555,-0.10229444,-0.00360296,-0.09567305,-0.028044771,-0.06527036,0.066627786,0.09738148,-0.006487518,-0.052807614,0.032935828,-0.040636092,0.025449092,-0.017649328,0.027415374,0.018293707,-0.022456067,-0.007503609,0.016644057,0.04389196,-0.062405743,0.012481453,-0.046135005,0.012408668,-0.0796624,0.033468965,-0.05327275,0.08021813,0.06684954,0.038268283,-0.023358226,-0.07297586,0.06865002,-0.0013398146,0.029714655,-0.0004087437,-0.06907792,0.012145337,0.035167553,0.031758927,0.070710234,0.00263962,-0.041495215,0.0014866451,0.033801418,-0.044884145,-0.023450239,-0.1414285,-0.010406577,-0.055494666,0.023868216,-0.00852349,-0.037172955,0.0682811,-0.023196377,0.0015082322,-0.038255785,0.08868737,0.002669352,0.06207191,-0.093390636,-0.085333094,-0.061237708,0.020338237,-0.00558076,0.021590438,0.03346001,-0.013145636,0.05314549,-0.048409805,-0.07008857,0.044282153,-0.05986618,0.026231112,-0.041003473,-0.023279043,-0.10869505,0.07113849,-0.027115658,-0.046811797,0.05558809,0.0024480193,0.04011118,-0.0066812937,0.04478614,0.017396007,0.029228931,0.10130286,-0.059322942,-2.1039597e-33,0.026694344,-0.05899913,0.05163851,-0.002825768,-0.010804926,0.12541348,0.05085244,-0.056722187,0.0913439,0.010147553,0.11138078,-0.006458183,-0.036261294,-0.04691914,0.019889588,0.02464048,-0.05506851,0.05485987,0.033228014,-0.06725734,-0.026044812,0.004749348,0.03264137,0.060096644,0.052977823,0.048013963,-0.024548281,0.0033055162,0.0010052224,0.007607694,-0.114181615,0.0411231,-0.02287906,-0.05690232,0.013970597,-0.047365602,0.021206103,-0.0414908,-0.0047107753,-0.08565955,0.08019611,0.11065147,0.01976895,0.085628174,-0.018146152,0.07108414,0.06693465,-0.0119598955,-0.14567436,-0.057116136,0.030243445,-0.0656389,0.01806169,-0.0015023847,-0.04216262,0.05790605,0.07514265,0.038493183,0.045299653,0.052320134,-0.051438995,-0.006761373,-0.012862042,-0.025594778,0.07293612,-0.02627563,-0.033552203,0.0022749265,-0.021718422,0.05419868,0.10628921,-0.0048778676,0.07813156,0.062391464,0.020255627,0.034204975,-0.00028934586,-0.0068254923,0.031089846,-0.11580901,-0.073737405,0.052633118,-0.016068814,-0.06895927,0.046568632,0.039946202,0.00386552,0.013556678,0.005450105,0.03631292,0.0024338497,-0.037852332,-0.052239485,0.0732638,-0.0083747525,-4.13895e-08,0.04860027,-0.0140958475,-0.034191955,-0.048668317,0.020645034,0.05953782,0.058610648,0.05793882,0.045365136,0.051482268,0.0023079256,0.013662919,0.04504685,-0.053205326,-0.04279086,0.09738179,-0.023149656,0.0130713275,-0.028067887,-0.021244965,8.781959e-05,-0.033977337,-0.023519004,0.04350311,0.039712034,-0.039745755,0.03922337,0.10926171,-0.037623834,-0.07818106,0.037563253,-0.051940676,-0.026941739,-0.04423596,-0.07265696,0.03280681,0.009840496,-0.10291258,-0.008748259,0.047854412,-0.0057170843,0.026846718,-0.024767864,-0.041212786,-0.00823031,0.0027118134,0.030541325,-0.083405934,-0.016875092,0.019407624,0.011971584,-0.05206945,0.051187888,-0.071524,-0.1132931,-0.015731886,0.0018097623,0.0026580172,0.00094914436,-0.0906739,0.043036565,0.008900834,0.13156563,0.0065046125 +2.7.11.18,"Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.",384,1.0,-0.044355504,-0.106815875,-0.008250215,0.031558987,-0.04043539,-0.08316472,0.0629987,0.02147492,0.03735629,0.029141495,0.11736934,0.01320982,-0.011418994,0.10356477,0.037531186,0.075669646,-0.01431036,0.028929548,-0.0113535505,-0.056093313,0.010916601,0.0227278,-0.032701224,0.009955916,-0.10531324,-0.086167686,0.013065654,0.022343274,0.050519735,-0.10122422,-0.074177,-0.050387535,-0.042066697,0.0054399758,-0.0144135,0.08348022,-0.041361358,-0.04075081,-0.026578998,-0.007705969,0.07274604,-0.04538373,0.07949804,-0.012998449,0.020424005,0.010297063,-0.0044479347,-0.0076496047,-0.047421355,0.007303001,-0.048484854,-0.05483281,0.013455602,0.06758044,-0.0060166363,0.09228239,-0.17765345,0.042597935,0.02647392,-0.01781326,-0.02468964,-0.010501776,0.010851257,-0.0030908536,0.06348054,0.018107934,-0.059124276,-0.007248352,0.006156189,0.023094345,0.034418277,-0.059709053,0.018632434,0.046664454,0.03349552,-0.04173127,-0.03566652,0.0030977114,0.023914967,-0.0029195095,0.0014147869,-0.01903899,0.0025164566,-0.020286957,0.042531405,0.044727903,0.03874985,0.059368826,-0.06902953,0.04459714,0.09761163,-0.025245527,0.013133732,-0.059225302,0.037326805,-0.0032899703,0.045499448,0.015699476,-0.043876562,-0.03329993,0.087030046,0.011061696,-0.024430873,0.016212767,-0.026709648,0.027047792,0.035093863,0.00037681728,-0.050359447,0.0796783,0.035112213,-0.014699192,0.023649529,-0.006161004,0.02351707,0.09418882,-0.02276254,0.0033664594,-0.020619635,-0.020020809,-0.035515312,-0.078585334,-0.049041808,-0.0069089537,-0.10347351,0.07278929,-0.052314486,4.8329345e-33,0.04062348,-0.058014125,-0.036019303,-0.014544831,-0.038591236,-0.08616407,0.004169223,-0.11423192,-0.063565575,-0.11540067,-0.08552595,-0.021473126,0.02820233,0.114936106,-0.06735798,-0.033236284,-0.012494615,-0.007978939,0.080753826,0.033435393,0.042763226,0.03533913,-0.015133423,-0.03977945,-0.0061537772,0.03473151,-0.060388315,0.06865762,-0.034621846,-0.02472667,-0.024051784,-0.029886527,-0.036965538,0.07087999,0.055948544,0.00061626796,0.03630046,-0.06441983,0.03329327,-0.04829504,-0.021070529,0.04765116,-0.024068696,0.011290022,0.05224057,0.01096874,0.012345187,-0.05106137,-0.07878375,0.06876531,0.029469823,-0.0070697134,-0.008967499,-0.09673752,-0.004678422,-0.038018167,0.012990832,0.006927895,-0.044242,0.08598897,0.011462377,0.0061173267,-0.004275033,0.056283813,-0.017134266,0.102728404,-0.11976649,-0.018769002,-0.023031479,-0.0056524226,-0.031453487,-0.004712949,-0.028386803,-0.068279095,0.13388246,-0.03460065,-0.04854872,0.010289676,-0.123121575,0.018429644,0.00059934356,-0.02979493,-0.081343256,0.12936337,-0.0058921427,-0.017278546,0.04690601,-0.033425502,0.009776975,-0.00051791413,0.009775149,0.0063349823,0.04226614,0.10408367,0.0010657737,-6.403811e-33,0.09236138,-0.055086497,0.13337788,0.009304064,0.024907913,0.104354724,0.0674921,-0.04416032,0.0722318,0.028312339,0.0936551,0.01306667,-0.0959177,0.0071799154,0.021811781,0.03037676,-0.06530138,0.086340874,0.00749196,-0.032972895,-0.07242001,0.091715366,0.024442777,0.04818595,0.038180634,0.05845135,-0.041778386,0.02805931,0.0013172828,0.026050437,-0.06823993,-0.033958673,-0.07588385,-0.05174294,-0.022007653,-0.008832007,-0.048078757,-0.009204695,-0.028234692,-0.021687042,0.039958656,0.055718917,0.03178858,0.065491736,-0.09061747,-0.0014139448,-0.022896685,-0.03534179,-0.14784652,-0.029667858,-0.017519798,0.027619889,0.018099008,0.026386123,0.031603266,0.05783232,0.09028737,0.07630873,0.009876038,-0.018971866,-0.07929266,-0.09209776,-0.04328874,-0.051126797,0.086062215,0.013811213,-0.0124792745,0.0010001723,0.007018675,0.031636275,0.06273094,-0.017992634,0.025240388,0.059589546,0.027455403,-0.028197074,0.015849937,-0.041830536,0.07120571,-0.04146243,-0.053311903,0.02567627,0.010965773,-0.07804224,0.07978378,-0.009987881,0.037911624,-0.05665994,-0.022604018,0.044312384,0.11527223,-0.016043285,0.0034622229,0.013947914,0.0124320965,-3.507211e-08,0.03290439,-0.06733774,-0.02726875,-0.06571576,-0.022135029,0.005945011,0.032348547,0.044324614,0.020000853,0.021187391,0.07689448,0.018868642,0.074194774,-0.008234538,0.04843282,0.01532794,-0.044061724,0.013028095,-0.017661504,-0.07402246,-0.08717968,-0.065897435,-0.05532954,0.03637999,0.007820624,0.013534701,0.06634073,0.110796355,-0.0077679125,-0.015260541,0.03737735,-0.029058633,-0.016916336,-0.03851117,-0.04821216,0.017291583,-0.0346516,-0.06285056,-0.05580315,0.03882522,-0.05707153,-0.029016897,-0.025515815,0.019867435,-0.018789252,-0.01722626,0.009294024,-0.06265035,-0.008229305,0.054086447,0.009906149,-0.060837794,0.009325653,-0.058306914,-0.1062093,-0.024228103,-0.0117475,-0.0033483186,-0.03352427,-0.027417209,0.06546547,0.043941557,0.09592836,-0.059511963 +2.7.11.19,"Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b [5]. The gamma subunit of the tetrameric enzyme is the catalytic subunit.",384,0.99999994,-0.026188679,-0.036509305,-0.052104056,0.027103474,-0.053856943,-0.0073844725,0.029372994,0.0072357436,0.03284035,0.008963498,0.022610154,0.01443136,-0.0011251885,0.087971725,-0.0048097423,-0.078907266,-0.058391824,-0.004190065,-0.004187462,-0.1023922,0.05580654,0.015995217,-0.038217742,0.053733516,0.033235885,-0.06717604,-0.026667869,0.026465513,0.014814627,0.010406585,-0.10547644,-0.06916139,-0.06324429,-0.022845145,0.04802359,0.07935331,-0.09533711,-0.01985359,-0.072498485,-0.041830774,0.061078355,0.016849888,0.009377762,0.0033029267,-0.053515773,0.029941905,-0.005124303,-0.01968892,-0.016016915,0.06308967,-0.060445454,-0.052206986,-0.0011568395,0.02694924,0.009107529,0.05470512,-0.035749912,0.004626822,0.007673206,0.005022132,-0.028915979,-0.039451063,0.04597632,-0.023833683,0.068357356,-0.02620269,0.0011625674,-0.061507326,-0.028690139,-0.0068890057,-0.070741296,-0.04255795,0.019642549,-0.007330743,-0.0055723325,-0.043835465,0.0062217973,0.063868165,0.033616506,-0.028049849,0.07770167,-0.10893973,-0.042015683,0.049378913,-0.011684874,0.057781614,0.046558376,-0.0005165618,0.0846544,0.0520739,0.027673196,0.008542511,0.016493034,-0.041054964,-0.005098699,-0.032591235,-0.0019767415,0.0072039715,-0.03243657,-0.071713455,0.06450566,0.07275942,0.045728013,0.000875055,-0.02549897,0.037999455,-0.03437071,0.04332656,0.024577508,0.05049174,0.10153879,0.044534095,0.07306269,0.051097985,0.00079370535,0.09312289,-0.020074392,-0.022123836,-0.008096045,-0.0654223,0.022393622,-0.038369644,-0.01736859,-0.0050254697,-0.071808144,0.06670975,-0.11186195,4.8563624e-33,0.04792803,0.0041250535,0.021904467,0.00072209863,-0.0034025863,-0.057489093,-0.041605633,0.029195677,0.014444629,-0.07600307,-0.018690351,-0.03981751,0.055353727,0.101856105,-0.019724797,-0.05920209,-0.0063559664,-0.00014316716,0.060253307,0.038614012,0.028470779,0.0655353,0.028086051,0.018479377,0.0676491,0.098511755,-0.12360777,0.033844892,-0.06349561,0.013997151,0.009209212,-0.08403276,-0.100810006,0.028181963,0.10469277,-0.023336582,-0.004694913,0.039756466,0.09251398,0.06672605,0.040181514,-0.02045256,0.011839215,-0.032711025,0.0001878628,-0.031275738,0.0031674094,0.07658654,0.022801843,0.019942822,0.022274783,-0.005901012,0.09009521,-0.057980884,-0.070775256,0.015060082,-0.007825646,-0.039810546,-0.03712402,0.0106673315,0.022201672,0.023162503,-0.02696928,0.04742994,-0.06735402,-0.0044854498,-0.0928396,-0.05678038,-0.015065219,0.08736468,-0.010789145,-0.0065234867,0.098781124,-0.038006965,0.04258577,-0.03384388,0.012110388,0.021453645,-0.11943375,0.022212883,-0.0020815032,0.012792623,0.010417651,0.06888768,-0.0040173526,-0.025874984,0.058394838,-0.03060174,-0.012987481,0.060745995,-0.058956567,-0.018220162,0.03517696,0.10276771,-0.06998143,-6.393788e-33,0.091367714,-0.05861286,0.08630046,-0.051458098,-0.036478296,0.049857542,0.0021720047,-0.058933742,0.030999154,-0.035522487,0.043472942,0.035687264,-0.061709672,-0.03676327,0.022581,0.0057484233,-0.033334076,0.117067516,-0.016571809,-0.033868045,0.053182617,0.0525715,-0.022125293,0.031732533,0.09741779,0.0011839275,-0.041062396,0.02070598,-0.029202139,-0.010860283,-0.07891836,-0.039619677,-0.028854974,-0.03950594,-0.075810365,0.00024853175,-0.04646447,-0.0034003719,0.055773687,0.09542587,0.06888462,0.08844946,0.06460231,0.04909818,-0.007644216,-0.0013574181,-0.039854497,-0.03784538,-0.17625453,0.0396111,0.08164867,0.010552274,-0.02155944,0.03467036,0.00062177016,0.102392845,0.015747642,0.073992826,-0.051514156,0.019924238,-0.016238391,-0.05524733,-0.008970708,0.0023527653,0.06853532,0.032115392,-0.0172194,-0.00994511,-0.010759517,0.011517,0.0065217745,0.0030121168,-0.0060508843,0.057157286,-0.019259915,0.0034218563,-0.0751704,-0.017829206,0.038661454,-0.07980718,-0.019352177,0.03856575,0.032784417,-0.059325512,0.016058283,0.00976767,-0.0131259095,0.11858758,0.03870939,-0.0033570905,-0.027365055,-0.08551674,-0.010050995,0.053893644,0.10553899,-4.1808004e-08,0.03623785,-0.03583733,-0.079576716,-0.040065333,-0.05037086,0.034617294,0.047701325,-0.009742048,0.010781208,-0.015049404,0.041020524,-0.022356698,0.038820643,0.03308892,-0.043595463,0.05842255,-0.10981758,0.03686905,-0.060775504,-0.023333821,-0.057931542,-0.05090781,-0.10570715,0.07963995,-0.010589492,-0.053880364,-0.039271556,0.108565606,-0.070915654,-0.053487957,-0.057754137,-0.008551182,-0.06776898,-0.09245992,-0.07201723,-0.040259793,0.0043266355,-0.058000185,-0.03530112,0.05436096,-0.027981319,-0.030952372,-0.014933033,0.019427633,-0.0094454065,-0.019210698,-0.00673887,-0.05724339,0.005987903,0.07737314,0.0069592157,0.03604049,-0.03211585,-0.083549686,-0.11290505,-0.04947106,-0.04272619,-0.020096598,-0.020583495,-0.054894395,0.11252975,0.06269068,0.11303431,-0.12290812 +2.7.11.20,"Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].",384,1.0,0.021524556,-0.04287259,-0.026312975,0.05970201,0.090840735,0.022976879,-0.0019412754,0.015152914,0.03626608,0.01329668,0.09214512,-0.06650326,-0.024989037,0.036341235,0.033377785,0.022652095,-0.07160548,0.06766698,-0.010353946,-0.09735688,0.0690286,-0.011977625,-0.010281465,0.026936999,0.009001098,-0.033960536,-0.06287614,0.057608794,0.031134544,-0.058189645,-0.047461435,0.010389587,-0.0009515488,-0.045254417,0.046636328,0.0589387,-0.037331067,-0.059879255,-0.0815287,-0.032077063,0.13316706,-0.00026226896,0.017510017,-0.044788294,0.014883026,-0.020610187,0.07084292,0.0043708556,-0.012471301,-0.016054079,-0.035863154,-0.07175491,0.004009009,0.03496009,-0.01164608,0.04758866,-0.057555553,0.09081765,0.0620435,0.0018642397,-0.021434741,-0.019074617,0.07325714,-0.011800457,0.053836692,-0.045295622,-0.015935587,-0.08301269,-0.044681843,0.016407209,-0.0599784,-0.044745877,0.07748518,0.037683833,0.07379352,-0.025853282,-0.05652725,0.003586164,0.04175163,0.0014906112,0.042084,-0.06908015,-0.00928608,0.0034362911,-0.047520094,0.021969581,0.06968574,-0.0505189,-0.009942126,0.037092473,0.066621885,0.0010753691,0.03322366,0.0021028488,-0.043163177,0.0041424963,0.0007803027,0.021898396,-0.04856271,-0.05445815,0.02501129,0.08824306,-0.014884379,-0.027470702,0.0067763287,-0.017573945,-0.0036489319,0.023235932,-0.004829638,0.027371394,0.047731943,0.0026798751,0.07028782,0.06038865,0.044072628,0.14318316,-0.030555803,-0.077735946,0.021488521,-0.012011281,0.050097805,-0.04334336,-0.04234936,0.0123917395,-0.08497613,0.010802114,-0.11298316,3.1246043e-33,0.028574437,-0.013557093,0.027180463,0.059376255,0.0077122184,-0.050619878,-0.061684176,-0.038207203,-0.032432035,-0.14262806,-0.040860582,-0.049079444,0.06214099,0.07059088,-0.033773948,-0.10486712,-0.026608877,-0.036581658,0.079902,0.021200132,0.029503854,-0.020767055,-0.01647557,-0.0033243815,0.063896075,0.0106246425,-0.024957228,-0.0024539807,-0.010826512,0.021626543,-0.056267053,-0.08114807,-0.10103334,0.048170567,0.060824405,-0.08790855,0.06325321,-0.010275999,0.04188347,0.0030922948,0.026880387,0.03281997,0.019281492,-0.0025831603,0.011255411,-0.09013077,0.019804107,0.056502357,0.057410613,0.03895891,0.07671901,-0.003961617,0.08781547,-0.056022193,-0.03991291,0.00806357,-0.042365387,-0.05838078,-0.049953114,0.018142704,-0.063427284,-0.027423432,-0.044328794,0.08013758,-0.020230247,0.04307206,-0.08349351,-0.063591234,-0.02624851,0.026047852,-0.03304162,-0.017486524,0.11102086,0.007908649,0.009178282,-0.042274054,-0.025120003,0.049649198,-0.060867768,0.036610622,-0.042099487,-0.020929532,-0.036047105,0.078085616,-0.050619904,-0.09696578,0.003234246,0.045560613,0.011816276,0.03900635,-0.021169502,-0.028474161,0.04229835,0.09292246,-0.023205195,-4.0676164e-33,0.077972874,-0.061617844,0.07792688,-0.040425494,-0.007817109,0.06637718,0.007933935,-0.04595926,0.08389112,-0.028870417,0.03495693,0.05251576,0.04356475,-0.050028436,0.05831967,0.005688747,-0.046996616,0.11514354,0.009777769,-0.036083903,0.019125862,-0.00046891833,-0.0077783233,0.023845134,0.10281428,0.015242773,-0.040718712,0.05120244,-0.032754734,0.05078021,-0.12309134,-0.004890582,-0.033979677,0.009631117,-0.013502937,-0.020121656,-0.020140577,-0.059568226,-0.041353207,0.015061632,0.040870644,0.06612341,0.009753572,0.04340614,0.02674218,0.052022412,0.09045025,0.036247425,-0.10927336,-0.00044370734,0.008290024,-0.013760956,-0.047274604,0.060035165,-0.003902743,0.090720944,0.025528744,0.11163824,-0.017473366,0.042072333,-0.017623167,-0.04048881,-0.018385176,-0.071287185,0.07152151,-0.031071695,-0.0531473,0.0053064344,-0.029588733,0.045354497,0.10892389,0.06877123,-0.015609865,0.054659933,-0.08773773,-0.007336932,-0.0388433,-0.02726376,0.017862065,-0.088921204,-0.032244764,0.023384232,0.011432035,-0.08503045,0.015478234,0.031037135,0.0100322375,0.04887279,-0.018990314,-0.0032169227,-0.041039236,-0.112856545,-0.0718358,0.08440109,0.042440075,-3.8641236e-08,-0.030405173,-0.033376023,-0.030761406,-0.04661901,0.045453522,0.034389593,0.047953043,0.06644383,0.031920873,-0.016769608,0.009355452,0.008684566,0.079599425,0.0025813123,0.02607971,0.07267175,0.018364757,0.060032345,-0.027549561,0.0014600024,-0.0009250736,-0.09584431,-0.086427696,0.0719147,-0.013767377,-0.0861916,0.0038962108,0.12175946,-0.021809837,-0.08856092,0.017688094,-0.051066276,0.021322932,-0.073402755,-0.07270077,0.012194061,-0.05071365,-0.10231856,-0.04167447,0.037133314,0.009935652,-0.004381237,-0.008736601,-0.038388558,-0.04679034,-0.0055413297,0.053443957,-0.06559368,0.0006386974,-0.010626656,0.041044008,-0.06148995,-0.03515784,-0.06305859,-0.07430565,-0.0050481134,-0.020226298,0.01645383,0.03943034,-0.043878313,0.05245261,0.10304499,0.13682155,-0.072453074 +2.7.11.21,"The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].",384,1.0,-0.07401024,-0.06740099,-0.0842766,-0.10025343,-0.00029819433,0.009149732,0.0031336618,0.040608916,-0.05105311,0.015088263,0.030861575,0.03993845,-0.033652794,0.025152452,-0.07378109,0.05872565,-0.082329564,0.039294496,-0.025458407,-0.08907974,0.014053332,-0.046725165,-0.007283774,-0.028537536,-0.017129082,-0.02360107,0.04513424,0.07678149,0.024211122,-0.058846395,-0.03219941,-0.01055743,-0.068996735,0.018672919,0.051944166,0.057813935,0.00072921114,-0.09420569,-0.03867756,-0.110499464,0.15018514,0.004012866,-0.04949723,0.019921867,-0.01370208,0.037453998,0.0650997,0.024242533,0.0108854035,0.03964429,-0.02335946,-0.038310893,-0.008538529,-0.018529642,0.029225871,0.061395023,-0.022863504,0.026303416,0.036585573,0.05974401,-0.06106152,-0.05301184,0.08580057,0.071880415,0.13298039,-0.028296273,0.007315082,-0.068045534,-0.07672601,0.011068811,0.060423173,-0.07539758,0.0099606505,0.062093675,0.04072505,0.026155988,-0.035118368,0.0044553573,-0.03439353,-0.049771808,-0.07398765,-0.03698502,0.03259291,0.07933971,-0.0014669438,-0.0072082803,0.01688219,0.00033632503,0.018737055,0.019546717,0.0077144317,-0.00094108836,-0.0036522548,-0.033962194,0.027380556,0.0587222,0.002570792,0.06271339,-0.10058128,-0.040241674,-0.030557448,0.035273027,0.058423985,-0.0685378,-0.056800626,0.018211033,0.016080258,-0.041850273,-0.08602873,0.0014738167,-0.0031161143,-0.0026200828,0.08767075,0.06670053,0.015681984,-0.04640771,0.090310894,-0.013556789,0.078001805,0.048543397,0.018043412,0.01779006,-0.028893972,0.036717147,-0.051693358,-0.025926374,-0.107054844,1.5208094e-33,-0.013310023,-0.02627332,0.013842292,-0.023767896,0.031683985,-0.049869794,-0.03357559,-0.0691592,-0.035507444,3.7755082e-05,-0.001986617,-0.016916115,0.06035651,5.1539933e-05,-0.090386696,-0.018979715,0.081438586,-0.018095037,-0.016859008,-0.0033252682,0.009807598,0.00062827737,-0.052279305,0.015699347,0.028853053,0.036458537,-0.024900945,0.0015731802,0.038083736,-0.00059264334,-0.023266444,-0.03690048,-0.114384666,0.008568189,-0.0009661288,0.03271,0.013499721,0.0050548855,0.019490236,0.052334584,-1.769594e-06,-0.07820746,-0.0770921,-0.016875973,-0.018486505,-0.07500085,-0.041594032,0.05102544,-0.010331587,-0.047882143,0.052059777,-0.059877615,0.053014383,-0.057491776,-0.004506012,-0.010712009,-0.021093346,-0.029526412,-0.01237003,0.008821421,0.016820654,-0.032617595,-0.051651575,0.093947165,0.06855527,-0.029288925,-0.050368443,-0.047161445,-0.085675076,-0.0023235474,-0.042128928,0.027037648,0.06790504,-0.008394469,0.024768218,-0.002545769,-0.05900553,0.019457243,-0.11172023,0.025356162,0.041312046,-0.06477669,-0.053742323,-0.02234659,-0.06000563,-0.03166999,0.0356128,-0.021049058,-0.041983515,-0.040657673,0.08440996,-0.0391176,0.011919141,0.03858039,-0.047894996,-4.600099e-33,-0.09060283,-0.050312977,0.15054569,-0.043296836,-0.02398635,0.07682704,0.13314709,0.010688653,0.013587393,0.053493027,0.005216676,-0.058549337,0.012714205,-0.08575377,-0.017920716,0.09057767,-0.04716771,0.06834939,0.081073664,-0.054174364,-0.018828543,0.111593895,0.048890214,0.08341473,0.00845989,0.011725396,-0.047201637,0.08153903,0.0020978213,0.07846922,-0.0524349,-0.010396493,-0.010352686,-0.04085666,-0.015318785,0.0038901528,-0.036649622,-0.056811668,0.049337473,-0.013931642,-0.063812286,0.021800354,0.029528812,-0.003105153,0.023413632,0.065860175,0.017997494,0.0754842,-0.095707245,-0.027723022,-0.02128039,0.14483704,-0.042430837,0.017549748,-0.013503809,0.09029287,0.053239536,0.03062946,0.00330142,-0.014147198,-0.019368013,-0.097307034,-0.02809688,0.1484845,0.045546826,0.018523602,-0.051889755,-0.025925552,0.04098603,0.062151127,0.009840934,0.0180118,0.04576284,0.004300807,0.010485167,0.047584545,0.007224974,-0.025321806,-0.012253152,-0.0497809,-0.07481677,0.042631757,-0.06622661,-0.03613286,0.029439425,-0.06904791,0.026086295,0.047866195,0.0016558857,-0.03649853,0.009452203,-0.055087186,-0.15570115,0.06610337,0.018015947,-4.30103e-08,0.0888507,-0.005563077,0.048160512,-0.035335645,0.015672304,-0.04148475,0.051035266,0.027033553,0.05369278,0.033373166,-0.05532984,-0.01083451,-0.0067401202,-0.041294307,0.07116958,0.06114102,0.01852557,0.055660836,-0.00018081428,-0.07173051,0.085767955,-0.05009386,-0.032081686,0.07467033,-0.041132905,0.040330116,-0.044776224,0.02972555,-0.08368448,-0.042433694,0.050158292,0.006887312,0.0736245,-0.025154045,-0.085623026,0.051649675,-0.03663581,0.0092885755,0.027928049,0.028450329,-0.0056962036,-0.03483773,0.043165315,-0.007336702,-0.043323975,-0.0059513003,0.10775744,-0.0020407483,0.08048569,-0.0061795935,0.027477974,0.027720312,-0.012795408,-0.111052275,-0.041182283,0.03643191,0.007650098,-0.0015232556,0.014430581,-0.059219886,0.0016928826,0.07156967,0.085853696,-0.08965012 +2.7.11.22,"Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.",384,1.0,-0.10453137,0.022942822,-0.06729686,0.031811107,0.059510436,0.018282851,-0.025889963,-0.0053943167,0.06512025,-0.07206583,-0.00056872814,0.021307498,0.04800738,0.048373666,-0.007245793,0.0564899,-0.09646091,0.07658579,-0.024504675,-0.08270344,0.034721185,-0.01805729,0.0022612202,0.09801169,-0.033426292,-0.034269787,-0.014351888,0.037440363,-0.020816514,0.073060185,-0.055301543,0.08660629,0.047097057,-0.0003327878,-0.020018779,0.069908746,-0.06315063,-0.042678725,0.00034515996,-0.080200404,0.024275921,-0.0434632,0.006829295,0.0076510743,-0.02003356,0.04816533,0.0127693685,-0.014662687,-0.040792417,-0.002745437,0.031821933,-0.060608763,-0.020381473,0.0074757184,0.051827174,0.028194185,-0.07201795,0.018849375,0.023896543,-0.10677614,0.02567704,-0.048603434,-0.05240434,0.087813295,-0.01608133,-0.009831272,0.0053921607,0.010333648,-0.052607954,0.017517652,-0.04027524,-0.064325035,0.0014356101,0.007657098,0.02062298,0.06342867,-0.015155313,-0.021277566,-0.054569967,-0.08142953,0.043073386,-0.02934582,0.100058734,0.06315413,0.0138499355,-0.08729266,0.019384274,-0.04480441,-0.03999697,0.07280964,0.09399813,0.0075263986,0.057394832,-0.06318792,-0.0063376273,0.02809152,0.054477017,-0.0041985554,0.006319346,0.018062139,0.002088557,0.013665239,-0.04751891,0.01920016,-0.07986309,-0.004641793,-0.01568269,0.0033363008,-0.045277927,-0.0072756503,-0.033252604,-0.019852372,0.052809596,0.007821858,-0.0059990888,0.12593332,0.026513696,0.011026323,0.072881855,0.062210627,0.022204954,-0.038941786,-0.01848999,0.09411191,-0.013049461,0.062526785,-0.04029657,-1.2439019e-33,0.0077993292,-0.0079405615,0.047303423,-0.031680513,-0.030289382,-0.065884516,0.018552275,-0.09967515,-0.007303315,-0.07771536,-0.04454608,-0.024817402,0.016522462,-0.021623163,-0.03572931,-0.012672786,0.0017985239,-0.04745107,0.054022968,-0.026645424,-0.012779638,-0.01343271,-0.07722356,-0.041012853,-0.023198687,0.05420755,-0.00028604316,0.010561663,-0.110862754,0.008723106,-0.030743774,0.011525225,-0.023031544,0.028149832,0.081692345,0.013016889,0.016750878,0.021461746,0.044528913,0.09901757,-0.041864328,-0.12399191,-0.021938011,-0.01066828,0.059906192,0.016410023,-0.0620166,0.060363173,-0.035337705,0.026439965,0.10190842,-0.04162768,-0.0016735456,-0.051062282,-0.0031617365,0.04690373,-0.051420927,-0.06766544,-0.04348093,0.0040684394,0.040538553,-0.036208414,-0.06135936,0.11382212,-0.006514512,0.057971135,-0.102070436,-0.056465667,-0.108919024,0.06746974,-0.011700184,0.008490297,0.07021905,0.014891476,0.025270218,0.0625124,-0.031165585,0.05223111,-0.045507204,0.10974476,-0.00022315817,-0.04184086,-0.07055381,0.0036200976,-0.0067432295,-0.05149241,0.022007138,-0.08461623,-0.044983726,0.00026859553,0.056342218,-0.0966816,0.0101164505,0.07700442,0.05883026,-2.028211e-33,0.08620567,0.03357226,0.10417873,-0.062310625,0.048041467,0.06208337,-0.012629948,-0.108671255,-0.0077868635,0.0009678857,-0.049222995,-0.013813236,-0.073302254,0.0443409,-0.04220581,-0.030833999,-0.04410239,0.015014386,-0.07146752,0.04755054,-0.032302774,-0.008696822,0.017023573,0.01887197,0.035516303,-0.033783734,-0.07344729,0.15936837,0.046308987,0.08790636,-0.1414712,0.018111402,0.018838618,-0.02031339,0.024818664,0.087611675,-0.033142902,-0.05602498,-0.009887768,-0.008624565,0.0046498165,-0.019919954,-0.039600395,0.030199526,0.09764131,0.07611043,0.08870468,0.023894466,0.0023475992,-0.06652221,0.00686835,0.07845064,0.0022192819,0.062608376,0.02088421,0.12724687,0.055000607,0.07185885,0.0507787,0.033123508,-0.028598677,-0.019500284,-0.007744912,0.061593827,0.029388921,-0.034512024,0.024392063,0.061336204,0.036234222,0.036963306,0.015135863,0.007935885,0.009960848,-0.021325583,-0.06873891,-0.019177064,-0.04399772,-0.027739333,-0.053815383,-0.043432325,-0.09113697,0.0033067227,-0.06564778,0.004014702,-0.09819931,-0.05375749,-0.0010333392,0.027573656,0.012019028,-0.049306605,0.01847016,-0.027566541,-0.072419,0.10416926,-0.0027982462,-3.901579e-08,0.04513984,-0.04362062,-0.006259939,-0.07301442,0.0899599,0.0064198603,0.09625163,-0.012565045,-0.018061679,-0.008945262,0.030293992,0.007765869,0.02398371,-0.031671092,-0.006397347,0.062479477,-0.010061489,-0.035052422,0.020239482,-0.0017953811,0.0056273574,-0.08766103,-0.043740414,0.04818851,-0.034280494,-0.101871334,0.016196335,0.13489504,0.038728543,-0.08226393,0.04912689,0.0016452202,-0.0072099813,0.0029982643,-0.064501725,0.049701106,-0.06585608,-0.0722872,0.06357727,-0.044218253,-0.05143109,0.038720164,-0.04353529,0.0018203343,-0.019274035,0.0050453804,0.059722804,-0.06726598,0.0112474635,-0.02357353,-0.0633271,-0.013101207,0.0058509414,-0.024148356,0.032034133,0.032653265,0.041395903,0.022584882,-0.031156674,-0.056626692,-0.034415044,0.047760945,0.08468925,-0.087062486 +2.7.11.23,"The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.",384,1.0,-0.038144566,-0.019872764,-0.07482732,-0.048115566,0.014368251,0.014878972,-0.08272837,0.02232655,-0.019399732,-0.0008188995,-0.029004633,0.016752379,-0.019616427,0.04589483,-0.05746518,0.03541547,-0.14823723,0.002176405,0.014959253,-0.07377301,0.04626155,0.028990123,0.030470176,0.018693209,-0.06715366,-0.028586697,0.093370706,-0.006720678,-0.027854284,-0.069760375,-0.056752943,-0.07398683,-0.016881794,0.033361938,0.080548376,0.11647711,-0.06818849,-0.11799662,0.004033335,0.008394525,0.13741174,-0.012520196,0.04047762,-0.011555373,-0.053626828,0.053401858,-0.064918384,0.028961495,0.06410055,0.042266823,-0.007669863,-0.050679933,0.01578664,-0.020213084,0.018196622,0.09103091,-0.018899392,0.010878902,0.047088318,-0.01315164,0.021101065,-0.03008478,0.017111475,0.0717404,0.09295378,-0.03675146,0.049678653,-0.011568164,-0.06213449,0.0063628145,0.0012420468,-0.029077968,0.0008504258,0.12001127,0.017363219,-0.028973358,-0.037965238,-0.0010799787,0.015468417,-0.03125799,0.01858877,-0.06751074,0.008667929,0.005394729,-0.075113855,0.055075776,0.0091363285,-0.0024852797,0.045693222,0.04003943,0.007916676,-0.07175945,-0.013176165,-0.07536071,-0.03938712,0.042909328,0.03695135,0.07752975,-0.023688769,-0.08128259,0.059969123,-0.0013094534,0.038538616,-0.052810673,0.009560896,0.013497436,-0.0059001474,-0.03594799,0.031379443,0.011113149,-0.083243266,0.084932946,0.09365807,-0.034933742,0.027657393,0.025255369,0.03893135,-0.015932342,0.034901563,0.07023051,0.025315803,-0.06211902,0.015952835,0.055462435,-0.04330159,-0.040065434,-0.080180295,1.4493868e-33,-0.0083586825,0.016364312,0.052817646,-0.09193109,0.014215615,-0.0068935202,-0.014966806,0.022973165,-0.14858271,-0.1031868,-0.05645858,-0.05506459,0.049327467,0.042813044,-0.054482955,-0.038568467,0.06018005,0.042455446,-0.065345645,-0.05612075,0.058521677,0.013566877,-0.06916739,0.08395142,0.01758687,0.03235179,0.029283745,0.04658741,0.055248257,-0.018084798,-0.021021947,0.01304675,-0.07410062,0.12779975,0.07534442,-0.016355183,0.0140671395,-0.026102046,0.041899145,0.088621825,-0.0044609574,-0.0735874,-0.018786296,-0.026970059,0.013736955,-0.037724182,-0.06891484,-1.5925782e-05,-0.041801587,0.048968624,0.095442794,-0.02606587,0.07783423,-0.035916608,0.019530205,-0.020186208,-0.043202348,-0.05271758,0.053717196,0.01497581,-0.0217405,0.031768117,-0.04844773,0.0669648,-0.009025664,0.030457782,-0.055352777,-0.12538724,0.0026526756,0.09524578,-0.012080824,-0.022825368,0.07295802,0.017058227,0.017747693,-0.020270811,-0.08310682,-0.029928746,-0.097669855,0.080465995,-0.0865525,-0.03936889,-0.018295644,-0.0015683598,-0.026039608,-0.051721975,0.031128835,-0.09031063,-0.042421456,0.0030502342,0.054266263,-0.07805833,-0.018505257,0.06380054,0.03826154,-4.5685717e-33,0.05397283,-0.041677576,0.12301699,-0.031452175,-0.0589876,-0.013342204,0.051251795,0.006056598,0.006867852,-0.052878413,0.05390195,-0.01697043,0.040220212,-0.021211544,0.019988861,0.083888255,0.008229497,0.08017977,-0.0015883573,-0.01896696,0.0152659835,-0.0014289166,-0.040555313,0.064157575,0.03765954,-0.014499283,-0.09453144,0.074044004,0.0067527387,-0.018626798,-0.07605975,-0.01692239,0.0058449833,0.044302873,0.008010358,-0.022477893,-0.01650228,-0.05406003,0.05006623,0.023267215,-0.0018380248,0.035253026,-0.014699585,0.04776492,0.021465898,0.060172964,-0.022828115,0.048371043,0.011764558,-0.08556185,-0.004362182,0.046514027,0.011443966,0.066389136,0.015951116,0.0066397884,0.024534225,0.086970285,-0.016375212,-0.053491876,-0.044751734,-0.07079582,0.04344038,0.11614005,0.046363123,0.032749526,-0.025066642,0.025556283,-0.0079523865,-0.017657595,0.029396346,0.023307543,0.0117909955,0.026794355,-0.023955489,0.008622692,-0.04555699,-0.033217624,-0.041172396,-0.04360622,-0.02041354,-0.016888186,0.008118474,-0.065698594,-0.022627985,0.025049336,0.050510705,-0.016533878,-0.014837019,0.026161917,0.010575933,-0.011562767,-0.08325382,0.04186862,0.05429463,-3.8883865e-08,0.024025569,-0.03295837,0.008444147,-0.10726758,0.07393656,-0.0014024369,0.047915142,0.027106622,0.05671679,0.037106823,-0.039248485,-0.0075025787,-0.053271476,-0.039806664,0.058244377,0.0009512149,-0.10836534,0.030285956,0.003942305,0.044626955,0.0004218117,0.021439098,-0.108275905,0.03681026,-0.06859264,0.020785665,0.043941017,0.07916347,-0.02243543,-0.029553762,-0.02666452,0.0045104725,0.02027918,-0.058579564,-0.123072095,0.02719039,0.050088152,-0.023636406,-0.03936562,0.046793595,0.030503288,-0.08056527,0.0313311,-0.0068818466,-0.075564496,0.011133051,0.08961213,0.004969601,0.055696208,-0.050818935,-0.0035978614,0.022958262,-0.06527613,-0.093228914,-0.043708008,-0.0023237437,-0.065144256,-0.035512965,-0.061161716,-0.051489912,0.017686263,-0.003868358,0.2062428,0.0020472729 +2.7.11.24,"Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.",384,1.0,-0.025156474,-0.0042059175,-0.06293721,0.021569926,0.08089228,0.03682858,-0.0064307093,0.10878867,0.025839198,0.07543057,0.036479212,-0.031157447,-0.0042614904,0.007376022,0.0019285976,0.068931125,-0.08127225,0.03296722,-0.009164627,-0.0704538,-0.02138893,0.0085244365,-0.002730769,-0.0067393812,-0.008099408,-0.022882886,0.037112046,0.053912133,-0.053092025,0.0058370805,-0.043567248,-0.0455962,-0.008289697,-0.012469168,0.012377566,0.12427674,-0.056356777,-0.11026131,-0.061974898,-0.07517963,0.028153006,-0.079995275,-0.057802033,-0.005658557,0.053717926,-0.0037305,0.030244712,0.014097224,0.008187184,0.065360874,0.015077594,0.01807428,0.008939985,0.05193721,-0.00015826778,-0.005173572,-0.100148,-0.037402682,0.023755316,-0.015114146,-0.10452718,-0.02656866,0.07035785,-0.033089146,0.058768455,-0.003136102,-0.055301033,0.030547744,-0.03144541,0.010808204,-0.017523563,-0.028821696,0.0643458,0.013089184,-0.038997043,0.016853575,-0.05077882,0.03961358,0.019084252,-0.05109173,0.019641465,-0.027198337,0.037579246,0.059886526,-0.059525535,-0.024586674,-0.019598337,-0.00015309888,0.018277705,0.14645326,0.06397724,0.00340766,0.04601813,0.011653229,0.032916214,-0.012644966,-0.07247688,-0.002587152,-0.065523446,0.015637945,-0.033201564,-0.029916123,-0.09078701,-0.04022289,-0.017618261,-0.036266085,0.049801998,-0.033715587,-0.04874381,0.027733808,0.009829173,-0.020557303,0.06844585,0.014236357,0.03495522,0.06633714,-0.0009397086,-0.028917829,0.08707471,-0.010074836,-0.022526737,-0.03906111,0.007095356,-0.0076032626,-0.026504334,0.026900174,-0.016752223,2.9209811e-33,0.05807804,0.098621204,0.06750176,-0.06861399,0.05624508,-0.07626635,0.0064839465,-0.04291663,-0.049466465,-0.04601446,-0.044028502,-0.029228734,0.031511445,0.00052482315,-0.02757714,-0.01581757,-0.0075119156,0.036017414,-0.015522205,0.0058324407,0.0011360212,-0.059350003,0.008666007,-0.0026611951,-0.014382519,0.08264395,-0.08618497,0.010773525,-0.09310269,0.023962475,-0.05867517,-0.005830255,0.05373365,0.003150777,-0.017663466,-0.053697355,-0.006149958,0.016717404,-0.0008249451,0.017111748,0.027243512,-0.059756808,-0.08741183,-0.0012288487,0.013012422,-0.08586952,-0.019414416,0.06947319,-0.031994216,0.009411012,0.08332772,-0.073697455,0.017000552,-0.006764341,0.029200347,0.038735114,-0.122660786,-0.05157481,0.053512435,0.05290083,-0.05243296,-0.06782279,0.03623148,0.057454705,0.028187584,0.0046792063,-0.119598925,-0.06025097,-0.115674235,0.07307303,-0.010379097,0.010068214,0.076514766,0.014257855,-0.0026670762,0.08542608,-0.059865955,0.0637654,-0.15065539,0.06203945,0.027511777,-0.017141217,-0.016483245,0.0041374615,-0.04136081,-0.0009876424,0.020326752,-0.050900694,0.015110711,-0.00736153,0.048183605,1.8917752e-05,-0.07999256,0.040360898,0.007974056,-4.6093587e-33,0.046574857,0.0007571817,0.013360725,-0.062433578,-0.011340603,0.07256315,0.08148722,-0.056173094,0.096090026,0.0137836505,0.026320735,-0.02120089,-0.035569552,-0.044068553,-0.0047106207,-0.05423508,-0.0017481248,0.15995035,0.013827957,-0.08840269,-0.004889614,0.03700525,-0.04691785,0.085544035,0.067326516,-0.0015421773,-0.08979785,0.068074234,-0.05012303,0.13389412,-0.00997646,0.04390974,0.026639791,0.0082865795,0.12383033,0.026484722,-0.024746602,-0.005477363,-0.016199106,0.049670015,0.01705457,0.034831434,0.025616385,0.0007653569,0.011066314,0.057614416,0.0243256,0.032235164,0.010466937,-0.012647843,0.03310195,-0.012100041,-0.0048880694,0.048035175,-0.022736117,0.11273907,0.0072611794,0.03725796,-0.0019658217,0.02062521,-0.0452672,-0.089949206,0.07245194,0.026557708,0.077237956,-0.08260966,-0.014958986,-0.00668307,0.030508438,0.051443245,0.011368212,0.027811227,-0.024695508,0.0036050384,-0.05415332,0.030089702,-0.03984464,-0.013907279,-0.0510205,-0.0455172,-0.07256317,0.034721658,0.014976567,-0.03183851,-0.05331472,0.12462525,-0.013978816,0.04032094,-0.005512516,-0.018644648,-0.043617092,-0.07723246,-0.1704664,0.080090344,-0.06764527,-5.163715e-08,-0.028620258,-0.010828732,-0.056151595,-0.022327295,-0.03483383,0.031352233,0.0974673,0.050871797,0.0043027196,-0.035887618,0.035026997,0.052144445,0.05101767,-0.07260778,0.018748688,0.015294964,0.078135446,0.079067916,-0.026125798,-0.06488027,0.035004802,-0.06844829,0.035601676,-0.00931745,0.020216364,-0.041932702,0.045587234,0.06902453,0.06644179,-0.10587168,0.05333351,-0.079217434,0.029432306,-0.0010467425,-0.03853338,0.08630763,-0.076799095,-0.0834774,0.013028729,0.07081264,-0.06620997,0.049705554,-0.017554559,-0.03455215,-0.07652572,0.051574428,0.095898196,-0.031980593,-0.051964417,-0.042595666,-0.060990024,0.05170808,-0.02371145,-0.024494307,0.0072068432,0.049243953,-0.033542883,0.010448681,0.01655958,-0.075720906,0.050810974,0.008232238,0.051201962,-0.07092205 +2.7.11.25,"This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.",384,1.0,-0.05217112,-0.008824797,-0.08028619,0.073941015,0.10879459,0.041693434,-0.014579245,0.098787375,0.017901028,0.03345407,-0.03178689,-0.042128816,-0.007110332,-0.0046026064,-0.0083793895,0.10144107,-0.012847574,0.09375365,-0.021929542,-0.047602836,-0.04548736,-0.05757911,-0.0006731555,-0.023564903,-0.005661629,-0.011676568,0.04470139,0.060512923,-0.025795018,-0.024322482,-0.015356947,-0.075374044,0.0020799045,0.02528708,0.0025684035,0.107826546,-0.06656856,-0.10542315,-0.08537298,-0.097669475,-0.009847931,-0.041065022,-0.0016899791,0.030085161,0.079297855,0.020338502,-0.04196177,0.051551647,0.021005208,0.00102621,0.021642184,0.01792907,-0.011702565,0.03170053,0.017966023,-0.016638884,-0.11266765,0.0025863235,0.056888025,-0.0054058717,-0.07655234,-0.040160157,0.08348349,-0.0064209485,0.0323819,-0.015792018,-0.037704922,0.06094776,-0.015397595,0.016612556,-0.04687646,-0.015417541,0.06163623,-0.00490245,-0.05857265,0.052397575,-0.05731493,0.07782186,0.0287966,-0.040310767,0.051600542,-0.01374755,0.039158504,0.032469608,-0.06345314,0.0014893027,0.010644157,0.022482125,-0.0021593496,0.13179065,0.06982469,-0.015775615,-0.014122264,0.05657638,-0.011945455,-0.0106071625,-0.027268395,0.010610094,-0.08276995,-0.0027668884,-0.05453346,0.02514013,-0.07306736,-0.04021288,-0.02651164,-0.064230986,0.028998792,-0.026074398,0.0004118535,0.045385595,-0.020144844,0.024668,0.022015858,-0.040289752,0.042502895,0.060971446,-0.009913345,-0.034996547,0.045439396,0.03344126,-0.034752574,-0.05714277,-0.053696234,-0.07236197,-0.03207655,0.0015193685,-0.004403152,1.4449849e-33,0.045345247,0.06478805,0.041473437,-0.020635042,0.005957094,-0.07671612,-0.0047332835,-0.085685365,-0.063869014,-0.057511035,-0.042521887,-0.0068679703,0.015770663,0.0020685424,-0.05191991,0.028634362,0.019128647,-0.03759928,-0.009515223,-0.016052196,0.00052637234,-0.036211405,-0.015857153,-0.029609162,-0.008502484,0.05703481,-0.026094198,0.009142527,-0.06641477,0.03024278,-0.05362275,0.009341996,0.021952791,0.0057390234,-0.0044600796,-0.061699715,-0.03188286,-0.023354655,0.01814637,-0.006809063,0.005085065,-0.0529096,-0.11158205,0.042353056,0.015249506,-0.07067323,-0.0237592,0.060076762,-0.0024283945,0.00855062,0.05898296,-0.028265603,0.02168369,-0.030884746,0.020720463,0.005669629,-0.08885719,-0.07460874,0.027026545,0.040120445,-0.041202378,-0.09652326,-0.011563557,0.0891426,0.03339597,-0.0033627136,-0.14970653,-0.02365304,-0.08000371,0.05360473,-0.018372908,-0.004929414,0.054519825,0.007430909,-0.06651536,0.05641154,0.03117612,0.031208547,-0.13709633,0.083119705,0.029289799,-0.009564307,-0.03676814,-0.019587908,-0.0013667583,-0.013594046,-0.06593526,-0.07503397,0.009334662,-0.0381283,0.037371393,-1.1422153e-05,-0.040883698,0.08538565,0.0011337507,-3.980732e-33,0.07042439,0.010043489,-0.027278658,-0.07248968,0.039751988,0.111085676,0.11211555,-0.06272356,0.057393573,0.039539043,-0.0015606629,-0.0064719473,-0.035351787,0.020559054,-0.0041924594,-0.07034687,-0.028963529,0.15809774,0.015698103,-0.034721363,-0.012453346,0.0962375,-0.02728889,0.09320656,0.029804235,0.0133460555,-0.103366524,0.057972956,-0.078128666,0.14782396,0.05752009,0.044479482,0.0069924565,0.03525306,0.08887026,-0.02846191,0.0021083928,-0.032342028,-0.039808296,0.020252522,0.034528967,0.04235084,-0.021784361,-0.041911665,0.043512262,0.05408636,0.027762989,0.037781686,0.017451653,-0.03182293,0.0058907266,-0.0020833176,-0.02863209,0.07892166,0.0457211,0.079575695,-0.0006878898,0.033911224,0.04529266,0.07259497,-0.0872387,-0.065547265,0.061915714,0.025592536,0.0612313,0.009658439,0.051056936,-0.031978145,0.017330106,0.022792626,0.007456387,0.049184084,-0.013100442,0.019920392,-0.053946435,0.037162233,-0.024002017,0.034888245,-0.07493448,-0.04432989,-0.040772084,0.02014391,0.005198181,0.0048798057,-0.07287072,0.09331693,-0.03925035,-0.008052641,0.022457482,-0.035375338,-0.034930423,-0.058884684,-0.14679557,0.08070871,-0.052577227,-4.7320846e-08,-0.03438162,0.0036441993,-0.021283772,-0.060501248,-0.004421565,0.012766147,0.067235276,0.029047905,-0.0032317415,-0.0032270455,0.0294826,0.050004024,0.064359844,-0.08371362,0.004417449,0.02890849,0.07713687,0.047866646,0.005955061,0.0039829267,0.063972116,-0.09866333,0.09729606,0.044663765,0.044269282,-0.07350992,0.0456663,0.08323076,0.0742886,-0.0661685,0.031520166,-0.055852227,0.059625477,-0.0046533784,-0.075719304,0.08622931,-0.035384174,-0.0712578,-0.004693472,0.08765098,-0.016747829,0.021640679,0.04367114,-0.06614012,-0.07499497,0.046779823,0.07602114,-0.03894771,-0.045508873,-0.035864603,-0.084229335,0.020708557,-0.06759279,0.013312354,-0.029766632,0.020572865,-0.04378486,0.015813429,0.062670134,-0.11737009,0.060232088,-0.040234715,0.020361938,-0.03537073 +2.7.11.26,"Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.",384,1.0,0.009160148,-0.11659613,-0.0396847,-0.028299212,-0.060820986,0.11587889,0.060061865,0.058801208,-0.020742025,0.058040485,0.060666498,0.09571742,-0.008921214,0.07317314,-0.011070518,0.010405312,-0.11499351,0.0036481626,-0.034270506,-0.013288738,0.03611626,0.039837863,-0.014454764,-0.02195925,0.016122345,0.07542724,-0.02046919,-0.08108075,0.053196434,0.009124878,-0.033298615,0.02626065,-0.047275424,-0.09710138,0.033952307,-0.07254341,-0.09530374,-0.015547799,-0.07444778,-0.055146616,0.054106236,-0.077581264,-0.008788198,-0.046589084,0.03292913,-0.031855676,0.082708746,0.004736975,0.06732129,-0.023720447,-0.04772293,-0.0012643827,-0.0031739455,0.020818347,-0.039166022,0.06468717,0.00498609,-0.0054350537,0.0201673,0.0035400554,-0.09419512,-0.035684567,0.055253346,0.0086096935,0.067432754,0.0022145023,-0.032820825,-0.032837447,-0.021446584,0.05934222,0.04025061,-0.042156544,-0.027728422,0.046543073,0.07138037,-0.033211544,-0.06714985,0.017629586,0.011446832,0.046675503,0.041841164,0.018766237,0.08682971,0.093267016,0.10289781,0.03001032,0.05270699,0.05191003,-0.015759937,0.0461782,-0.01152811,0.005081098,-0.077017285,-0.034442883,-0.032442648,-0.05985741,-0.031627588,0.060945928,0.035480358,0.00859531,0.033080872,-0.05796339,-0.024452059,0.018702833,-0.012754416,0.046912797,0.024766581,0.0019418431,0.015742002,-0.002774657,-0.002085295,-0.09112344,-0.0049087116,-0.0012294436,-0.06925507,0.0022855334,0.049938373,0.0037553676,0.04898704,-0.03310936,0.050265376,-0.025785102,0.09770871,0.039867632,-0.077224135,-0.0004590735,-0.13099045,-7.46054e-34,0.03149029,-0.07052188,-0.03194181,0.00052070554,-0.013487011,-0.022474514,-0.07437747,-0.08350604,0.063062586,-0.03443222,-0.02631832,0.03401367,0.05009473,0.1118526,-0.057799257,-0.059166852,-0.025805345,-0.02402296,0.04109674,-0.07469566,0.06131305,0.122092694,-0.016486324,-0.012374953,-0.0051243226,-0.07560195,-0.11414367,0.06724576,-0.027453719,0.028232306,0.0054431832,-0.04015126,-0.0683976,-0.046342954,0.024401858,0.04777587,-0.030800853,-0.036235336,-0.079896756,0.050414972,0.0633869,0.017377848,-0.0922648,0.024703529,-0.031773966,-0.01697163,-0.007752407,0.07254649,-0.005144719,-0.028526602,0.07456312,-0.017019466,-0.045198075,-0.022144603,-0.00937564,0.04947793,-0.049486123,-0.044132106,0.038061164,0.03167224,0.0010880113,-0.0350736,-0.044864457,0.025340948,0.039612137,0.038163155,0.03799579,0.046168726,0.024074078,-0.08178551,-0.03988463,-0.036396112,0.0072985217,0.00016348141,0.013010026,-0.06159056,0.013929611,0.010807612,-0.062207814,-0.0192706,0.026918424,-0.07966567,-0.0025716654,-0.002365065,-0.023298016,0.081148855,0.06721563,-0.008714198,-0.06821993,-0.012026589,0.09804009,0.05036911,0.039924726,0.07002129,0.031977713,-2.6894971e-33,-0.08915227,-0.075437926,0.06756609,0.020286385,0.02280198,0.033248805,0.098901704,-0.07813688,0.10353441,0.009623615,0.017941868,0.018787406,-0.03566383,-0.045362115,0.008725384,0.022096697,-0.052748002,-0.008135922,0.026275186,-0.05019681,-0.07845715,0.057506386,0.07212934,0.03859726,-0.014744422,-0.0008841159,-0.053009804,-0.05585431,0.003927695,0.08822853,-0.049850397,0.03727653,-0.004906828,-0.045636173,-0.05093418,0.020464944,0.039195206,-0.050402362,-0.035156157,-0.06334923,0.051718626,0.0121242525,0.03107821,-0.005810941,0.01651525,0.039108414,-0.01168735,0.05825749,-0.14926507,0.048089575,-0.004472173,0.04545592,-0.026415309,-0.017240813,-0.06492455,-0.014643363,0.022445384,-0.0020460414,0.034299128,0.080298066,0.0067374557,-0.05130921,-0.030935634,-0.060002476,0.12950382,0.019909509,0.027104046,0.035718843,-0.028840914,0.01010793,0.03646118,0.023540832,0.013969864,0.036175847,0.098472446,0.008407845,-0.0719724,0.025249863,-0.0111523615,-0.0062492383,-0.06830892,0.09070172,-0.0499364,-0.034011528,-0.0014764116,-0.0493285,-0.010769002,0.041090157,0.012867579,-0.018723918,0.02597617,-0.075163774,-0.018299978,0.04905321,-0.026936792,-2.989345e-08,-0.004674812,-0.010583383,-0.033706546,-0.04231061,0.009341706,-0.08034313,0.012765637,0.10819766,0.052666172,-0.06797489,0.0013630026,0.082612164,0.02588602,-0.03950651,0.04516386,0.05824798,-0.031008678,0.013513455,-0.05238067,-0.09106569,-0.03483291,-0.041978773,-0.0031256308,0.060110528,-0.07690382,-0.055587552,0.077479474,0.08572107,-0.09737804,-0.06485036,-0.041030068,0.00614609,-0.047372613,-0.05328683,-0.09939519,0.038654618,0.03187825,-0.055724762,0.0058046193,0.004561116,-0.02039241,-0.084573336,0.060068715,-0.036617,0.012327443,0.060101695,0.022329284,0.045529027,-0.01691304,-0.06417253,-0.0010248492,0.068058416,0.041417237,-0.009457305,-0.0846142,-0.021780986,0.025446674,0.03499684,0.03625631,-0.0934051,-0.0018642077,0.047384292,0.15075003,-0.06374926 +2.7.11.27,"Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form [5]. Phosphorylates serine residues.",384,0.99999994,-0.011026896,-0.02839126,-0.05429773,-0.00794573,0.0818627,0.0784807,-0.026629023,-0.035743773,0.056749128,-0.0342138,0.012283793,0.021732546,-0.07151087,0.01300795,-0.013238768,-0.030189063,-0.07304108,0.037680082,-0.027078284,-0.0026987393,0.055601057,-0.011174117,-0.06832289,0.045831524,0.057401545,-0.08905727,0.071455516,-0.05746952,-0.09589306,-0.073099025,-0.012193931,-0.036012117,0.036628697,0.019689634,0.03455256,0.06317565,-0.013436877,-0.11139037,-0.025308035,0.0072929603,0.05688008,-0.006419453,-0.041290514,-0.059830435,-0.066874884,-0.011022108,0.0018920853,-0.016914893,0.06781017,-0.04539935,-0.0024894301,-0.026597248,-0.010229092,-0.017093629,-0.057901233,0.030805403,-0.052950144,0.019573105,-0.024955438,3.0214205e-05,-0.040724076,0.0027050138,0.11251446,0.022265764,0.053248104,-0.03386215,0.07840307,-0.052525952,-0.007106629,0.03486034,-0.1023541,-0.055580866,0.043577053,0.017453343,0.033403844,-0.013320995,-0.04348242,-0.06690211,0.09349831,0.025744062,0.008877272,-0.023423882,-0.020410381,0.048412893,-0.032348618,0.027101068,-0.012477092,-0.014738972,0.023621177,-0.0056389384,0.029849233,-0.08642937,0.016667478,-0.01964381,-0.01936394,0.028508198,0.03618061,0.02671294,-0.013705532,-0.0494459,0.01036162,0.10862626,-0.0433235,-0.058695994,0.04006174,0.035284646,0.012012076,0.07952204,-0.015226766,0.034640834,0.010748401,-0.06414095,0.07621001,-0.011615505,-0.017417734,0.10273989,-0.085229635,-0.06410037,-0.035108842,-0.0048218304,0.08290659,-0.0623847,0.045136176,0.058166463,-0.021564713,0.090748034,-0.071729094,3.9731243e-33,0.018998183,0.013885186,0.121142864,0.018605748,0.02917792,-0.067315295,-0.03598076,0.043482255,-0.026721561,-0.10573633,-0.011192012,-0.013895073,0.06664954,-0.02071031,-0.01260576,-0.08300932,-0.057135906,0.06303214,0.07655256,0.052014165,0.014315541,0.017728377,-0.0011961324,0.07561908,0.004523241,0.03390602,-0.08168309,0.04093216,0.06732813,0.044410817,-0.007472393,-0.019220315,-0.05180786,0.030246083,-0.016760742,-0.051672883,-0.07850357,-0.025902275,-0.01385821,0.06050673,0.12717701,-0.026253704,0.0026368925,-0.049986403,-0.01875606,-0.08060536,-0.025938297,0.12772427,0.037692938,0.02999483,-0.012549793,-0.014446109,0.09706287,-0.06411408,0.019682948,0.0070340186,-0.11525011,-0.03316762,0.04684543,0.036489584,0.03191508,0.07119952,-0.025978394,0.04558351,-0.0002738326,0.05265322,-0.123630285,-0.055059172,-0.013879882,0.08123153,0.01974305,-0.005296728,0.018144758,0.084325895,0.03360148,0.002986304,-0.0111164665,0.026753578,-0.05163978,0.07272428,0.022200547,0.026427839,-0.014511143,0.038093466,0.027017195,-0.037246965,0.032699503,0.028789671,-0.019942982,0.06430044,0.013340695,-0.08697183,-0.00062527304,0.06323015,-0.038392987,-4.675956e-33,0.15188088,-0.0904832,0.030637838,-0.07027771,-0.011808304,0.06360231,0.08277463,-0.02031868,0.06175875,0.020473663,0.037541755,-0.018825669,0.0069231163,-0.058512587,0.033378456,-0.033052612,-0.0065633487,-0.009881165,-0.0056118523,0.016732808,0.0041296147,-0.0038379957,0.01651628,0.07208388,0.0844168,-0.05310285,-0.07825063,0.040235,-0.048187334,0.008140706,-0.010019364,0.023959268,-0.012027803,0.008951422,-0.07455051,0.033342376,-0.045610163,-0.015813742,0.0058382573,0.039916057,-0.06296058,0.0243398,0.03565771,-0.0016531718,0.0912954,0.023376549,-0.048208334,0.07021884,0.010255684,-0.024198726,-0.037855577,-0.0035876299,-0.035958495,0.020024644,-0.0022686888,0.11483374,0.005536004,0.0901642,0.041075874,-0.037314273,-0.037796747,-0.026812453,-0.02208407,0.00031365047,0.037272356,0.005445526,-0.04180345,0.024509614,0.024762273,-0.061287988,0.06696191,0.055895343,0.031585597,0.05449349,0.0066870814,-0.058907386,-0.084423415,-0.018237066,0.009369951,-0.07700994,-0.055056024,-0.011542107,-0.0035758275,-0.055233855,-0.029132122,-0.002174781,0.024205528,0.038425244,-0.041254595,0.024447504,-0.090623565,-0.10807625,-0.09139794,0.062492542,-0.018841933,-4.155787e-08,0.06958406,-0.021559851,0.022984458,-0.092292055,0.043034416,0.0111007625,0.040681195,0.023647876,0.0049728733,-0.074085996,0.021113686,0.019284502,0.055073503,-0.013139971,0.028190952,-0.012658549,-0.028202564,0.06829464,-0.031531457,-0.026485885,0.019966418,-0.009371227,-0.06804889,0.10160469,0.011550429,0.03320956,0.07862266,0.05062553,-0.09401985,-0.039513767,-0.008883638,-0.022789504,-0.0082782805,-0.029982468,-0.01540586,-0.044613674,-0.0712585,-0.018243192,-0.08099604,0.13079026,-0.0008583967,-0.045935992,-0.030681295,-0.009917545,0.028981995,0.026631504,-0.0013744911,0.03583139,-0.017942103,-0.036652405,0.014435837,-0.022635462,-0.116334185,-0.0012359583,-0.031577162,-0.07444196,0.0107340645,-0.1039511,0.0066739926,-0.008649038,0.08739573,0.08977417,0.19593674,-0.045191016 +2.7.11.28,"The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein.",384,1.0,-0.05558632,0.0023407424,-0.050463103,-0.049422912,0.052258663,0.037129782,0.029814616,0.084193885,0.008866533,-0.03226379,0.045080192,0.05864137,-0.041982282,0.085300855,-0.022628833,-0.0065598683,-0.041630387,0.018677633,-0.052608844,-0.050989572,0.03178574,0.03848834,0.0018052845,-0.029657727,-0.060825404,-0.0385663,0.03940685,0.012997349,0.04479538,-0.092584245,-0.036899883,0.014106819,0.00054657715,-0.017714988,0.025918983,0.102203675,-0.009675511,-0.06252332,0.009725519,-0.04663189,0.08368469,0.030389186,0.03609092,0.03467057,-0.06081327,-0.038241025,-0.041856185,0.022130432,0.062113367,0.032374553,-0.055855926,-0.05560603,0.02453545,0.054567594,-0.046513967,0.094613664,-0.046117138,-0.007813425,0.0028865223,-0.056374535,-0.034305237,-0.06478911,0.03693866,0.03512626,0.123295374,-0.055433307,0.086906955,-0.08964299,-0.017712388,-0.02357694,0.06389449,0.007314487,0.013862478,0.06296883,0.003345513,0.047344856,-0.06198453,0.008242338,-0.008871891,0.020404505,0.05143602,-0.043502353,0.013527037,0.08582938,0.006641162,-0.0047661974,0.012823759,-0.056658026,0.02889489,0.06607006,0.06297499,-0.090551876,-0.024747,-0.064736806,-0.01463987,-0.013114,0.03439462,0.05640726,-0.024895186,0.01293096,0.042260844,0.022868287,-0.01692668,-0.021393685,0.015377733,0.05493471,-0.009006494,-0.05668864,0.009508813,-0.04249595,0.006560763,-0.003906149,0.11322535,0.011596919,-0.015833069,0.02310251,0.053227782,0.023280669,0.025044747,-0.008681474,0.036416687,0.04924612,0.050712433,0.08980548,-0.06223263,-0.015522288,-0.12873474,3.174271e-34,-0.010577446,-0.021922957,0.02659008,-0.054629285,-0.009815712,-0.03864986,-0.109992556,0.022475157,-0.0019519851,-0.1172178,-0.07845042,-0.031180274,0.04056453,0.009327039,-0.05068067,-0.06330088,0.03012799,0.04593213,0.03374844,-0.07715969,0.013294269,0.014315083,-0.06709734,0.06262304,-0.0012427474,0.040809117,0.026192227,0.078917176,0.016978754,-0.012866657,0.056826267,0.0042388975,-0.02837468,0.09691111,0.018640473,0.087022364,0.00971919,0.0015028839,0.066126704,0.018209804,0.0065940786,-0.014900953,-0.05344005,-0.02244274,0.011107129,-0.105065174,-0.09585731,-0.04564156,-0.019221544,0.021571279,0.033095744,-0.06886383,0.053781454,-0.05111295,-0.057318684,-0.015076982,0.019692311,-0.00996539,0.008668669,0.097371764,0.006540637,0.0147987325,-0.011983295,0.064350426,-0.008164263,0.029206103,-0.06566048,-0.10432779,-0.09795901,0.023308478,-0.027403956,0.051121157,0.10735658,0.10026435,0.012724154,-0.060689136,-0.07376243,0.0010428395,-0.14348987,0.02628771,-0.034985106,-0.030071488,-0.1145978,0.07059902,-0.099782854,-0.031051045,0.07177818,-0.076465644,-0.0074930307,-0.03514187,0.017332377,-0.05892237,-0.024480073,0.043025296,0.034784347,-3.0444951e-33,0.017269228,-0.09375204,0.11672534,0.025742235,-0.00060619175,0.035322204,0.0897019,0.034596786,0.04089946,-0.045390796,0.00993229,-0.05274763,-0.031954214,-0.03866808,-0.014093343,0.08504006,-0.023662193,0.060434736,0.0035789167,0.0018941858,-0.04349729,0.02728555,-0.028973663,0.07919085,0.047825523,0.03587595,-0.107830174,0.032128673,0.0017928157,0.059783988,-0.06717974,-0.018760193,-0.07989188,-0.07390242,-0.051700115,0.039306913,-0.043285772,-0.020213839,0.018441489,-0.0026133915,-0.0041274824,0.024699109,0.010003788,0.07984022,0.059072956,0.09406269,0.02307589,0.01687432,-0.0071112774,-0.038710482,0.019442743,0.04359364,0.017846128,0.053342402,0.037173934,0.0717566,0.06311787,0.0051233,-0.07107346,0.0076643876,0.001140383,-0.034504294,-0.0193516,0.031682897,-0.013032019,0.002339669,-0.039955195,-0.002526253,0.057417464,-0.023879295,0.00744753,-0.024682773,0.07937596,0.054101966,0.060472284,0.028745938,-0.02672152,-0.012129585,-0.010350956,-0.05954809,-0.07118985,0.0034989805,-0.045531508,-0.086652525,0.016943581,0.09390654,0.026853088,-0.02312072,-0.0588977,0.0135935545,-0.0073895897,0.03940304,-0.09137535,0.008863153,0.03387488,-3.4573006e-08,0.11741108,-0.12263574,0.033882316,-0.10247546,0.0020776442,0.018563215,0.027656317,0.015540834,0.006183158,0.013259516,-0.06291253,0.05779927,-0.10699141,-0.055088744,-0.033060826,0.06316848,-0.09409859,0.04745343,-0.04394712,-0.0061750985,-0.048159365,0.02552768,-0.03230629,-0.032397497,-0.026245533,0.054091576,0.021966396,0.051348746,-0.106856085,-0.042678308,0.08813806,0.0066741724,-0.007925524,-0.07004864,-0.06958464,0.02556504,0.036457345,-0.043251555,0.016294606,0.041762646,0.008446926,-0.04759949,-0.04511201,0.004968853,-0.03452188,-0.020598266,0.10542306,0.015894396,0.0064933025,-0.031984158,0.019256307,-0.023883343,-0.04464559,-0.0723442,-0.05992465,-0.010496797,0.04477638,-0.008203889,-0.007213209,-0.050216246,0.038945433,0.011814596,0.15938517,-0.027925624 +2.7.11.29,Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.,384,0.99999994,-0.042657156,-0.019031232,-0.021502104,-0.010966544,0.029448686,0.008429957,0.07627223,0.053505972,0.061456487,-0.05342307,0.02865503,0.06577134,-0.06688569,0.079230525,0.04823517,-0.036345597,-0.02630406,0.0065615196,0.02397719,0.0009319711,0.07376987,0.053294517,-0.00556098,0.009542451,-0.099863365,-0.027467519,0.05316061,0.0017258633,-0.042093027,0.049890205,-0.04815583,0.017827015,-0.0027976038,-0.027022459,-0.0047736075,0.052610315,0.019535912,-0.074869715,-0.029841393,-0.0048470134,0.10350861,0.0038206344,-0.0154727455,0.048626155,0.028258102,-0.012117507,0.026162721,0.013569313,0.05479074,0.031719394,-0.019524714,-0.06728299,0.042592146,0.06153385,-0.0413794,0.033038612,-0.066429056,0.0048790327,0.020665644,-0.027629673,-0.095387995,0.0063965614,0.06826915,-0.0249093,0.17481013,-0.04196355,0.047552597,-0.06940379,-0.040369395,-0.033702437,0.007620653,-0.004026427,-0.06313165,0.057877705,-0.03022829,0.112361535,-0.1040791,0.0069512585,0.096719265,-0.06494975,0.13540992,0.033780176,-0.0069931,0.12759937,-0.023608755,-0.02069928,0.0134171825,-0.006657659,-0.017788082,0.012271714,-0.022892265,-0.06858441,-0.0730185,0.028329967,-0.09795051,-0.04787843,-0.007749293,0.0020138691,-0.038088918,0.021800721,-0.0074829757,0.08343781,0.039472982,0.0003693238,-0.011412497,0.040489413,-0.054584313,0.03427221,-0.04726188,-0.016604414,-0.04490872,-0.049639348,0.071562976,-0.027143255,0.03330478,0.025412124,-0.06508706,0.014738943,-0.062108178,-0.02999533,0.012142016,0.050290037,-0.01491835,0.08648991,0.035378184,0.0954418,-0.08884705,2.9963615e-33,0.06348679,-0.089728445,0.07808834,-0.03722487,-0.022337895,-0.013982815,-0.026154896,-0.023616465,0.0157534,-0.02578538,-0.06513943,-0.069300465,0.05795892,0.0076090186,0.0034918217,-0.062102612,0.007355156,0.067110606,0.13968809,-0.06847749,-0.009617768,0.09180633,0.014570444,-0.029959379,-0.01887523,0.056533106,-0.09090203,-0.0038051815,0.03131524,0.02110142,0.020334054,-0.06524571,-0.10297887,0.011641845,-0.014174866,0.004993509,-0.00907853,-0.072195835,-0.002312136,0.008535649,0.029598834,-0.019127153,0.015835542,0.021090593,-0.019990752,-0.028464155,-0.070567004,-0.045790017,-0.047470365,0.0085180085,0.036560882,-0.08587105,0.035887193,0.0124991825,-0.10352432,-0.02448358,-0.04498455,-0.034520704,-0.011766789,0.06045944,0.052609485,0.07599506,-0.04459555,0.068048656,-0.0010215666,0.029573934,-0.10874309,-0.14205915,-0.042116266,0.11847953,0.035727173,0.022621116,0.12860079,0.03061367,0.014087951,-0.005478782,-0.027129186,0.012494389,-0.10571549,0.02379591,-0.08712018,-0.024738293,-0.08596238,0.10668292,-0.03995562,0.021810815,0.102939114,-0.0113223195,-0.040246457,-0.04986209,0.00042920042,-0.03687609,-0.014843608,-0.00448743,-0.012921495,-3.7274885e-33,0.018109947,-0.07820967,0.060442954,-0.058201946,-0.067944236,0.015479345,0.03881817,-0.06664048,-0.0052864524,-0.035740875,-0.0053017824,-0.044285186,-0.008783071,0.015687564,0.060810067,0.04041505,-0.10021997,0.016778354,0.009564222,-0.060768332,0.017010527,-0.03586569,-0.0077231596,0.16371854,0.09034221,-0.04942328,-0.039998125,0.021374853,0.0019837033,0.02024687,-0.0797066,0.008310977,-0.08277741,-0.018188845,-0.023372527,0.021191018,0.007915418,-0.019261857,0.015795195,0.021338236,-0.07616971,0.019732447,0.038723715,0.042955436,0.05904977,0.105017625,0.0017904768,0.0710445,0.047221106,-0.017326714,-0.030982664,0.017686673,0.03327591,0.01576674,0.030804789,0.060399946,0.045458708,-0.0057974737,0.013907055,-0.059104647,0.033815637,-0.015303993,-0.045942318,-0.0014951223,0.03296926,0.0060787504,0.054307133,-0.06946454,0.02520925,-0.030370777,0.044024616,0.07039772,0.09897535,0.06767461,0.07264242,-0.017166415,-0.006460746,0.041754942,0.033351563,-0.055149775,-0.025593404,-0.015866766,-0.0117434785,-0.0077809175,0.0060305,0.061860695,-0.008768373,0.06426944,-0.008751541,-0.015038025,-0.05378859,-0.012662181,-0.04091447,0.0027832622,-0.018302433,-3.459907e-08,0.06592228,-0.050045334,0.00980016,-0.09833945,-0.012216204,0.04261616,0.011283204,0.029509712,0.035833213,-0.03456109,0.034008957,0.0510137,-0.0037425046,-0.05859034,-0.015243965,0.027675992,0.0025729719,0.04702188,-0.022527453,-0.049617775,-0.025303258,-0.024706332,-0.09232857,0.016082715,0.059542228,-0.059446637,0.039495528,0.044865105,-0.046724614,-0.049366053,0.08575725,-0.02194657,-0.009883376,-0.032782573,0.07333268,0.009613716,-0.049175326,-0.007115604,-0.022232411,0.07010901,-0.09071596,-0.08002394,-0.02142319,-0.05190557,0.050717074,0.015676897,0.07297354,0.0123685505,0.013478761,-0.017131044,-0.063667156,-0.0015589631,-0.03497349,0.02857089,-0.047342245,-0.050139286,-0.023016047,-0.06860952,0.035093598,-0.028738437,0.04745955,0.092314914,0.08893146,-0.0033219752 +2.7.11.30,"The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].",384,1.0,0.0058949613,0.011557256,0.013492554,-0.025690109,0.05583157,0.0029102669,0.069209546,0.048406985,0.048578713,0.05468511,0.014592962,0.048746955,-0.018608054,0.033988513,-0.013792005,0.0800857,-0.045581646,0.11214165,0.005600508,-0.12071291,-0.012512773,0.034364715,0.017357444,0.00020657587,-0.008129355,0.007017447,-0.038141295,0.019840803,-0.0031542338,0.041898403,-0.099146865,0.048620902,0.011239622,0.03268481,-0.06094642,-0.024520325,-0.016461048,-0.063956864,-0.014646297,-0.0016020148,0.12055296,-0.01652621,0.018176848,0.0038570063,0.11674962,-0.016540317,-0.01216545,0.06869046,-0.010926084,0.01699287,-0.039324097,-0.04924066,0.032657318,0.09898152,-0.03544186,0.047349285,-0.041605026,0.03717118,0.062415596,0.013074127,-0.027329251,-0.06468534,0.028787421,0.03849889,-0.002325309,-0.008807863,-0.026831748,-0.055330113,-0.113212004,-0.012762736,-0.096130885,0.027757268,-0.03903913,0.04247871,0.01832465,-0.043048512,-0.008310553,0.069453105,0.01583562,-0.015445085,0.050595626,0.031450264,0.06692864,0.0399623,-0.051656853,-0.0051395786,0.010763649,0.004414077,-0.01696035,0.1436578,0.0025533678,-0.023252392,0.014873261,0.035550937,-0.049144723,-0.08093247,-0.046807427,-0.008635281,0.019088432,-0.0034446893,-0.080754764,0.0048419153,-0.011659672,0.01836488,-0.01747931,-0.012693631,-0.06821338,0.011247717,0.04472808,0.07954972,0.018612877,0.011748864,0.055054806,0.035753015,0.051238872,0.048771817,-0.0109820645,0.042718124,-0.0056079086,-0.048788313,0.075526215,0.021972915,-0.12941012,0.029813144,-0.07393428,0.08513208,-0.026343057,2.6000895e-33,0.025624126,0.03151953,0.101738796,0.11503955,-0.03545123,-0.00086503295,-0.011964422,-0.087858364,-0.06254007,-0.0025757593,-0.030788545,0.0122413095,-0.013379635,0.07676833,0.023486484,-0.007530311,0.00765778,0.044602577,0.084802955,-0.08770142,-0.017173728,0.040342823,-0.045697875,-0.0999653,0.031013079,0.03014293,0.03764963,-0.009550311,-0.026385326,0.0016051477,-0.07758062,-0.025546957,-0.017562652,-0.04626932,0.016151901,-0.10551534,-0.0027492878,-0.088313155,0.012785693,-0.014757947,0.06278151,-0.03057928,-0.08278212,0.010711824,0.013518912,-0.059342675,0.053919427,-0.013587789,-0.0065243267,0.0052518216,0.043573238,-0.03339643,-0.01291358,-0.048391644,0.032744367,0.052534692,-0.03833503,-0.02744897,-0.022706734,-0.020959506,-0.11700369,-0.117620915,-0.0219823,0.13866356,-0.034006327,-0.0020188617,-0.062075783,-0.10684946,-0.0407467,0.004110411,0.05108755,0.010850033,0.060621712,0.023133874,-0.084161945,0.008899037,-0.02479345,0.06469889,-0.057080533,0.0371704,-0.058638528,-0.027409479,-0.024476195,0.02121236,0.027226724,-0.09982758,0.04074542,-0.01496478,-0.0041687763,-0.059032865,-0.00095208036,-0.03588299,-0.033177186,0.09077392,0.038100854,-4.5797414e-33,0.02545784,-0.023026224,0.01073267,-0.07528477,-0.015789958,0.013126176,-0.032180592,-0.04317462,0.09227313,-0.00621795,-0.0032431767,0.04484921,-0.03962511,-0.07391477,0.0020149502,-0.13997489,0.037889104,0.051591992,-0.11644611,-0.083960876,0.006056806,-0.025452806,0.009132525,0.06681308,-0.08459731,0.011507124,-0.03968213,0.13423093,-0.055531226,0.07928967,-0.025148692,0.004046051,0.037124068,0.030625897,0.05637386,-0.022995036,0.007522966,-0.004854554,0.015312249,0.02499825,0.0049293637,0.01730914,0.073783904,-0.0043201717,0.013578729,0.115432195,0.15033416,0.07044322,0.023797184,0.0025253976,0.008575368,-0.031474292,0.008856527,0.04049729,-0.009025344,0.06683547,0.008084829,0.020344438,-0.007608827,-0.012428796,0.027773883,-0.035351843,0.055624083,0.03756764,0.009638456,-0.02077465,0.021307137,-0.016927117,0.061091308,0.060934342,0.03272732,0.07105048,-0.019234197,-0.021117311,-0.06399795,-0.04859041,-0.017014626,0.0003008553,0.0018592344,0.03997182,-0.05928354,0.0055382615,0.026770517,-0.032357696,-0.036111236,-0.036452405,0.013348128,0.052763905,-0.023061797,0.013324143,-0.051454686,0.0419121,-0.1328139,-0.008715828,0.00092860917,-4.4891273e-08,0.034744985,-0.005350342,-0.053384714,-0.08714844,-0.04700246,0.03716923,0.018766891,0.105205104,0.020298822,0.065382145,-0.079541065,-0.016305057,0.06946286,-0.034054182,0.027850898,0.013014536,0.018847447,-0.07223908,-0.044978134,-0.076378554,-0.0022066322,-0.06047178,0.064758144,0.05310656,-0.027294083,-0.13463554,-0.07252899,0.062328175,-0.07278665,-0.002216837,0.07528091,0.0014533286,-0.0050861402,0.037665684,-0.032392256,-0.006793772,0.0050185835,-0.058041673,0.069935784,0.03643942,-0.03304852,-0.017131206,-0.009926351,-0.01776707,-0.12733164,0.043108504,0.08641656,-0.014589591,-0.047715064,-0.024094915,0.02560871,0.0052144853,-0.09045809,-0.053370297,-0.043650564,0.08432562,0.008667538,0.04565797,0.08716336,-0.058554195,0.016490314,-0.002656085,0.04328621,-0.031766612 +2.7.11.31,"The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) [5]. Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP 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+2.7.13.1,A number of histones can act as 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+2.7.13.2,A number of histones can act as acceptor.,384,1.0,0.033874996,0.017470405,-0.024978312,-0.050934836,-0.08120356,0.02436529,0.06774135,-0.07551067,-0.015577489,-0.0036630742,0.050688952,-0.06547527,-0.027737636,-0.023331014,0.05472306,0.02612233,-0.031674918,0.0019521567,-0.103823945,-0.008004635,-0.043085188,0.027425291,0.05755043,-0.04059876,-0.061311074,-0.043208633,-0.05101284,-0.002080475,0.06854883,-0.12039867,0.013080837,0.03241358,0.078729644,0.040532637,-0.031387873,0.004318842,-0.030346531,0.056560434,0.0097788405,-0.02380609,0.024290819,-0.015937816,-0.0004379825,0.03293393,-0.06738583,-0.049187213,-0.05779114,0.0046184584,-0.013503444,-0.064262904,0.0036187766,0.0073187375,0.017199604,-0.008079845,-0.10332456,0.029696908,-0.06296674,-0.09106646,-0.009520354,-0.07283876,-0.019907134,-0.03256822,-0.01956943,-0.009443948,0.05030016,-0.016402842,0.042953365,-0.096537426,-0.016976938,0.015038333,0.11059351,-0.027307754,0.042434726,0.046874676,0.037472047,-0.006678178,-0.047012754,-0.008328083,-0.00037712482,0.026431536,-0.06468277,-0.028646734,0.057422098,-0.010522189,0.0526677,-0.004411385,-0.081306934,0.04014022,-0.10864182,0.10234652,-0.036960755,-0.0663483,0.041530278,0.009501521,0.033355974,0.008153194,0.039882027,0.022827836,-0.04344119,0.013403701,0.04053337,-0.0023035626,-0.019884469,0.068341546,0.01969881,0.010568733,-0.01581011,-0.041015852,-0.0045347926,-0.05211262,0.026210193,-0.14224295,0.055660073,0.044861075,0.009699728,0.084065855,-0.01793953,0.039179318,0.071466394,-0.011139487,-0.033501096,0.08273684,0.02322027,0.035449743,-0.014864029,-0.03437042,-0.12097594,-3.3460513e-33,-0.014025801,0.07900424,-0.00023670743,0.017287163,0.021937655,0.0024253405,-0.12499471,0.043593116,0.10227061,-0.1184074,-0.046187744,0.027659193,0.06235727,0.06509503,-0.077134825,0.014300828,0.01946194,0.0492432,0.019438624,-0.09844215,-0.04969219,0.018463263,-0.06427153,0.0018616101,0.009510597,0.025988275,-0.0032154068,0.03346315,0.04189611,-0.005012406,0.061808925,0.0574033,0.07675717,0.092582256,0.025502175,0.08276806,0.05944682,0.027853645,-0.032001678,-0.016755449,0.015931617,-0.018266097,-0.077886544,-0.010017025,-0.042194773,-0.02573769,-0.019141069,-0.06292026,-0.07205934,0.048698023,0.007888556,0.015390155,0.010868807,-0.016080309,0.034301475,-0.033154827,0.056835283,0.024830122,0.005254196,0.031125603,-0.04596272,0.01566733,0.049498133,0.02080448,-0.010765899,-0.014707115,-0.061129067,-0.045983333,-0.09433693,0.033587154,-0.04847572,0.0025827454,-0.029303549,0.012224695,-0.051803,-0.042397086,-0.016005928,-0.046480987,-0.053808514,0.06411031,-0.0014957334,-0.018000599,-0.07364148,-0.005006847,-0.041822013,0.0032586863,0.09321258,-0.16391471,0.073729426,-0.016332299,0.03414011,-0.0074298307,0.027876373,-0.059998248,0.020545097,3.3006729e-34,-0.022870874,-0.00979643,0.02800087,0.13279283,0.035903048,0.06598332,0.084180124,0.04811571,0.0837304,-0.013788902,0.03577583,0.041700315,0.08663127,-0.079273745,0.039819695,-0.0052618976,0.02388128,0.116269276,0.060539305,0.04683395,-0.10657199,0.04013722,-0.072875164,0.060546156,-0.046826284,0.06719019,-0.035773594,-0.08468282,0.052200455,-0.006203339,0.0015677583,-0.009882278,-0.0437554,-0.037991665,0.06570922,0.023613585,-0.05410449,0.06808902,-0.057887897,0.018087385,-0.013632245,-0.043512218,0.02212301,0.059311315,0.00068718265,0.029648535,0.10636119,0.099390715,-0.07293456,-0.023672346,0.037771247,0.0027009766,0.009003903,0.005333597,0.046657376,0.055178344,0.036824785,-0.06542777,-0.029515687,0.005070951,-0.039944828,-0.045425635,0.019276774,0.0147946095,-0.021425592,0.008524807,-0.07106666,0.03440669,-0.0031349966,0.08959388,0.024728673,-0.07428683,-0.0167568,0.05647872,0.025801364,0.03313809,-0.021819046,-0.097285174,-0.030553102,-0.07333103,-0.11260507,-0.008565475,0.05842333,-0.038147397,0.03367886,-0.081370614,-0.022109922,-0.0074509624,-0.026003497,0.05319424,0.037153654,0.055427477,-0.023718193,0.005878145,0.03558692,-1.9285368e-08,0.035276853,-0.07196753,0.059586227,-0.0479649,0.024572209,0.028551199,0.10361196,-0.09296975,0.05923667,0.058576755,-0.04879656,0.041267443,0.028649425,-0.015691949,0.02445967,-0.0003484009,-0.020851891,-0.012894542,-0.03617565,-0.02297281,-0.084138334,0.036920436,0.078455605,-0.11969231,-0.04322381,0.0055129873,-0.0055992766,0.052893173,-0.052240603,-0.014378933,0.0865602,-0.018735873,0.015572989,-0.0600461,-0.010153426,-0.011846657,0.08874951,-0.06461133,0.07214833,-0.019888535,0.06537272,-0.022550466,-0.10505385,0.04571694,-0.026519932,-0.04732168,-0.00445682,-0.039044034,-0.05037734,0.021911683,-0.03607672,0.10057022,0.04132366,-0.009296327,-0.0028048796,-0.0048821275,-0.023441667,0.066712864,-0.021379344,-0.025240678,0.060513888,-0.0020593116,0.044106685,-0.08274366 +2.7.13.3,This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.,384,1.0,-0.03725417,0.00088239403,-0.11486743,-0.07753755,0.013259778,0.0109755965,0.038277708,-0.007659882,-0.034457695,0.015916256,0.04672885,-0.02523078,-0.02351481,0.057800468,0.0018000964,0.016795276,-0.06263957,-0.04474879,-0.030561503,-0.057833474,-0.073537566,0.052181862,0.021278657,-0.041084748,-0.027485503,-0.060224123,0.009113494,0.057361048,0.014682768,-0.09726257,-0.030655654,-0.027117835,0.05263843,0.005992138,0.05690107,0.08874713,-0.08125298,-0.005470312,-0.0030359286,0.014787601,0.06474366,-0.0058565834,-0.013924686,0.023919715,-0.050777417,-0.01770406,-0.032475717,-0.039691582,0.009514967,0.014489152,-0.010829858,0.04509152,0.04446642,0.04553863,-0.07312495,0.07395875,-0.092091285,-0.04455511,-0.000926186,-0.039497226,-0.025458597,-0.08012224,0.01770479,-0.017756544,0.09697455,-0.0327168,0.028990503,-0.051113997,0.013814029,-0.027829159,0.048798643,-0.04571495,0.025173206,0.10865039,0.014128548,0.01157526,-0.08705506,0.022560192,0.007337442,-0.012771393,-0.04225915,-0.03944386,0.06576712,0.022179596,0.027963258,0.025709646,-0.10523185,0.041875813,-0.0088602295,0.08040862,0.009217866,-0.11620614,0.028017964,-0.08168008,0.009581579,-0.0065541985,0.046041925,0.007310215,-0.053272825,-0.0372641,0.037553888,-0.0121301655,-0.07752071,0.025827192,-0.022805136,0.06295808,0.031131903,-0.0075560687,-0.059823997,-0.014574174,0.010357515,-0.04266724,0.10383388,-0.030691266,0.027650358,0.07998291,-0.021243528,-0.044792116,0.07540873,-0.01578989,-0.04519778,0.043235004,-0.010053354,0.07221635,-0.07437435,0.022042045,-0.11729906,7.780811e-34,-0.0059248465,0.10506286,0.012687088,-0.023045555,-0.035296626,-0.009559291,-0.064369544,-0.031900767,0.078841604,-0.17686418,-0.06835546,-0.04246477,0.082003415,0.03444347,-0.07762907,-0.03071324,0.055369347,0.026897388,0.041517712,-0.074152485,-0.005790199,0.051638406,-0.0028253356,-0.008433081,0.0020755904,0.055913296,-0.035339493,0.005135957,0.051929843,0.00025438285,-0.031874344,0.036447205,0.035434067,0.10939677,0.066540726,0.02736925,-0.031388372,0.01577272,-0.012866705,0.049085863,0.047794066,-0.023079492,-0.1211674,0.009455475,0.014692788,-0.047731377,-0.029995775,-0.03286172,-0.035805907,0.018208602,0.03271849,-0.039764993,-0.0074664513,-0.06882549,0.0056202654,-0.024283033,-0.006073875,-0.08112713,0.013577202,0.07034608,-0.00013082131,0.0027124174,-0.0061124945,0.05119876,-0.012508503,0.0053674304,-0.13386591,-0.10568302,-0.0749287,0.049004756,-0.04113923,0.03213364,0.07476519,0.049897894,-0.0117159495,-0.007533731,-0.090577364,0.030912336,-0.08758762,0.05489559,0.046339955,-0.044077817,-0.076891825,0.027768362,-0.04098052,-0.069749326,0.11556558,-0.14930977,0.033864632,-0.008805248,0.021841465,-0.07151677,-0.011767325,0.020219149,0.05650485,-4.6997458e-33,0.044331033,-0.04314244,0.10625182,0.018254323,-0.008023709,0.11739313,0.061330743,-0.056767244,0.12676404,-0.00276953,0.0410692,0.012787267,0.02106435,-0.060771763,-0.024519153,0.010725384,0.008715207,0.11187026,0.00174032,-0.025407232,-0.060835827,0.008507829,-0.030400017,0.10675318,0.021056078,0.036173522,-0.083672054,0.019931644,0.04263082,0.0064713443,-0.03994945,0.017778303,-0.043652017,-0.071500115,0.08341367,0.035578433,-0.049974386,0.01651611,-0.032128308,-0.028157074,0.027061887,-0.013086804,0.035273947,0.030545317,-0.026869822,0.08670745,-0.014436961,0.059103414,-0.055719092,-0.07899319,0.024685003,0.014627056,-0.036148503,0.037129868,0.08591084,0.088382475,0.021737128,0.0557518,0.00815189,0.004600061,-0.04015541,-0.07408228,0.022090878,-0.0040272744,0.014742362,0.0061185285,-0.040782202,0.023818385,0.030524386,0.073008895,-0.00016833656,-0.009947519,0.057750974,0.05210268,-0.0044444874,0.054634802,-0.03238586,-0.057081003,0.018028902,-0.0940427,-0.11917613,-0.018028505,0.0070447423,-0.0568586,0.06453218,0.012888421,0.0023331253,-0.013905071,-0.03419973,-0.0407939,0.0383313,-0.040759947,-0.0863996,0.07899221,0.048334,-4.3246544e-08,0.110065185,-0.06296357,-0.006020602,-0.017439762,-0.008514936,0.05545584,0.075368494,-0.04449086,0.062439322,0.013052931,-0.009692976,0.028527431,0.046091665,-0.07764956,-0.01577098,0.009906636,-0.07179685,0.038767915,-0.012723178,-0.057395335,-0.01716197,-0.010773328,-0.006325503,-0.041712437,-0.011868996,0.014613181,-0.007735638,0.06474092,0.004005092,-0.098604396,0.08591712,-0.06261836,0.041044533,-0.08401197,0.014825354,0.040357016,0.07024437,-0.029942498,0.030822486,0.0044014235,0.051045496,-0.0021460964,-0.07408981,0.030248247,-0.0291999,0.00865046,0.017199013,0.024852056,-0.08035668,-0.019797493,-0.061232124,0.056093708,0.012554159,-0.059969936,-0.026918098,0.019979063,-0.04013093,-0.0124670025,-0.0391479,-0.039949916,0.039469223,0.0035544725,0.06766744,-0.01796401 +2.7.99.1,This enzyme was originally thought to use diphosphate as substrate [1] but this has since been disproved [2]. The activity is observed as the second part of a biphasic reaction after depletion of ATP. Tripolyphosphate is a contaminant of [gamma-32P]ATP.,384,1.0,-0.037875958,-0.018922783,-0.00382669,-0.06754108,-0.016670978,-0.024068533,0.08854741,0.05976409,0.007961999,0.030706003,0.039046947,0.00056793576,-0.024173478,0.065058686,-0.008718558,-0.021448497,0.038121752,-0.0064363377,0.09929895,-0.03002128,0.06065048,0.005603358,-0.043833703,-0.017681444,0.014260348,0.052759804,0.06420764,0.026078809,0.023228932,-0.037876204,-0.09872982,0.023956522,-0.014162502,-0.07698799,0.002776393,0.14457358,-0.08617617,-0.0067378096,0.006167022,0.008777385,0.077120796,-0.031785846,-0.05073505,0.008144662,-0.07297481,-0.044363484,0.025796473,0.0111914715,0.030088305,0.019388914,0.004969625,0.0040138806,0.018374503,-0.015408615,0.035314675,-0.014472177,-0.046632424,0.0053905593,-0.053203966,0.021743707,-0.015481506,-0.016851604,-0.043163322,-0.024977975,0.117590465,-0.04994323,0.021247027,-0.046179347,0.05264369,0.0065642395,-0.053605925,-0.021631844,-0.020137724,-0.021044195,-0.05664217,0.029474825,0.01781308,-0.0077650705,0.03726565,-0.07301839,0.04897344,-0.04927683,0.018947812,0.028790506,0.044281118,-0.007819475,-0.026087023,0.019331891,0.08339227,-0.0008811016,0.020367634,0.06734212,-0.029420445,-0.03201191,-0.036135748,0.05534055,-0.048560347,0.021671617,-3.4568537e-05,0.006904535,0.080283605,0.079941936,-0.028558671,-0.027839279,-0.037891805,0.04638685,-0.030442545,0.038642008,0.041134674,0.07125307,-0.018721137,-0.009504989,0.017597888,0.016948842,-0.018878007,0.13604304,-0.0102198925,-0.051834185,-0.074983515,-0.027687801,0.009420658,-0.061495043,-0.041586813,0.04315656,-0.02814877,0.05052051,-0.043889243,1.8932347e-33,0.051709674,0.044043858,-0.00796325,-0.04144302,-0.03800393,0.041367717,-0.037186258,-0.0005792258,-0.08024621,-0.0829997,0.026393551,-0.088253796,0.075295806,0.031033603,-0.048589613,-0.010602204,-0.013839769,0.06003399,0.12896948,-0.012750664,-0.017496105,0.019636743,-0.028310757,-0.030142158,0.015265261,0.019104356,-0.12181735,0.029692035,0.030240197,-0.0050283633,0.079612054,-0.09218057,-0.10983734,-0.006075405,0.067377426,-0.092077106,-0.039587773,-0.004114342,-0.035863835,-0.031141575,-0.02824652,-0.023468968,0.014174236,-0.019936137,0.0062288665,-0.10503912,-0.031797994,0.03860081,0.0021875517,0.027743129,0.08034319,-0.045483418,0.10868165,-0.09320353,-0.07547256,0.06917529,-0.002234405,-0.009713354,0.047342584,0.06785903,0.045518246,0.09870376,-0.06476602,0.04687268,0.07096077,0.041899316,-0.042355746,-0.093019605,0.008585518,0.06387192,-0.0596354,-0.020113664,-0.0005587048,0.026786182,-0.01981896,-0.03692026,-0.011653804,0.033805825,0.003895576,0.017474618,0.081724524,-0.09950228,0.008379554,-0.043751735,-0.092929356,0.02312111,0.017390242,-0.09829196,0.007079821,0.019714054,0.098947726,-0.029635705,-0.0736525,0.013835719,0.011885377,-3.5021878e-33,0.07093063,-0.05936112,-0.012177209,-0.092746764,-0.07868751,0.020555075,0.07847854,-0.06806966,-0.0057290266,-0.005299265,0.032525692,-0.005173568,-0.031304624,-0.05537514,-0.0457216,0.040531117,-0.033686854,0.06105069,0.0013112066,-0.01788524,-0.004252192,0.1245501,0.07994729,0.08810332,0.018841911,-0.005503706,0.054740466,0.012821669,0.04916085,0.040446263,-0.054032814,0.015940329,-0.010397934,-0.061073437,-0.0008432532,0.020104527,-0.026808865,-0.011514927,0.07514026,0.0056436383,0.012203555,0.10537048,0.06585457,0.008976065,0.002003948,0.059730396,-0.023560073,0.06909965,-0.088068284,-0.08329026,0.0060961987,0.028440893,-0.03500257,0.033051357,0.049568877,0.042276245,-0.044510264,-0.003961586,-0.0013554957,-0.033604316,-0.010856161,-0.04128337,-0.013385449,-0.04816273,0.09849704,0.09435598,-0.067930184,0.025430277,-0.0371856,0.007308129,0.038655415,0.034756422,-0.01911111,0.036019456,0.0051746923,0.045935865,-0.019519016,0.045553755,-0.026483033,-0.02230392,-0.007801809,0.08323954,-0.08946863,-0.077335864,0.027057523,-0.09451335,-0.07285069,0.10937484,0.012560209,-0.024104716,-0.00672686,-0.098583244,-0.03730501,0.11915042,0.09238994,-3.79791e-08,0.0022662058,-0.0034533439,0.05824955,-0.0449752,-0.018107805,0.009995357,0.0874368,-0.017682431,0.071009584,-0.0053523076,-0.055172678,0.03324065,0.023110708,0.02549705,0.059332203,0.04290457,-0.043675654,0.031023305,-0.07135074,-0.05581699,0.040173538,-0.08932112,-0.08599247,0.09047795,0.048694395,-0.035888407,0.04068769,0.029182198,-0.030649085,-0.108278066,-0.02151165,0.041814625,-0.017883103,-0.040961154,-0.017131798,0.028893977,-0.038473345,0.014964299,-0.035997048,0.01134995,-0.06559015,-0.05985938,-0.06513972,0.009423804,-0.00959729,0.06992948,-0.009691379,0.061191894,0.011400131,0.004828027,-0.015097244,-0.008670538,0.008748411,-0.08470057,-0.053748634,-0.04040444,-0.03491923,-0.06291145,-0.014825109,-0.090835616,0.09065174,0.03985869,0.12533404,-0.078848034 +2.7.12.1,This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.,384,0.99999994,-0.056540575,-0.025269536,-0.07252361,-0.087895826,0.051778007,0.005084377,0.03672384,0.046273157,0.07132952,0.008082179,0.07276631,0.04455382,-0.035795182,0.06711097,0.003552957,5.7718084e-05,-0.0855299,0.004335783,-0.00479228,-0.059075262,0.10245051,0.07366707,-0.011733277,-0.013418151,-0.013560943,-0.022337882,-0.01872604,-0.026956845,0.0045329635,-0.08680481,-0.04846894,-0.034033418,-0.028820567,-0.012999725,0.03558388,0.08973196,-0.04280696,-0.02261923,0.0063168486,-0.056804363,0.088987194,-0.029481834,-0.037539527,-0.10280589,-0.054009695,0.029412765,0.024002042,0.0141543355,0.030897869,0.042217504,-0.058935605,-0.063899316,0.038780812,0.014824968,-0.008571191,0.07180656,-0.04612494,-0.003267428,-0.022916669,-0.018569674,-0.08848183,-0.006178857,0.043432947,-0.04039214,0.10468553,-0.045964673,0.07841674,-0.011461568,-0.04069889,-0.050698623,-0.08058728,-0.07369874,-0.020671733,0.04959289,-0.03735275,0.056803405,-0.04312862,-0.017248604,0.043206807,-0.0138022415,-0.00059356337,0.04750702,0.015318656,0.08629555,-0.029980881,0.02274186,-0.020811513,-0.029635599,0.0696786,0.05122082,0.005146038,-0.10298147,0.0029125595,-0.082522556,-0.055363584,0.018533902,0.036376476,0.062313925,0.033829514,-0.03256353,0.03234352,0.04620676,0.056658175,-0.09772345,-0.04334568,0.04919618,-0.017488806,0.013610302,0.03466128,-0.015793953,-0.004867857,0.008410556,0.13076656,-0.04035006,-0.022405334,0.013076336,-0.062113643,-0.02763157,0.0061033806,-0.050401308,0.017683793,0.005385336,0.022321323,0.08761404,0.003846226,0.008403835,-0.123431474,-9.366992e-34,0.053180058,0.09511965,0.06254927,-0.065302506,0.042271532,-0.06174928,-0.037348352,0.041860472,-0.061101254,-0.06422332,-0.08204775,-0.11249832,0.024146767,-0.08748084,0.01218488,-0.06900275,-0.012224009,0.067002766,0.00557504,-0.00067041814,0.003978015,0.05524435,-0.050819997,-0.03412766,-0.008974661,0.046202037,-0.035188906,0.0012874258,0.021692608,-0.01060744,0.060550734,-0.012096274,-0.07870787,0.056952633,0.06433653,-0.032229595,-0.00093064463,0.01805042,-0.03005091,-0.030914145,0.033479474,0.011202163,-0.021259759,0.040771868,0.042346716,-0.09443267,-0.0346867,0.05836742,0.026433336,0.015754811,0.029431371,-0.096570835,0.04171034,-0.012039093,0.0024623543,0.039272692,-0.05700512,-0.0210573,0.035340257,0.118740655,-0.010250852,-0.0024302078,-0.06537856,0.049952704,0.044185605,-0.02438806,-0.057305098,-0.012203049,0.00063247746,0.16106695,0.011581758,0.02794642,0.099111974,0.06227344,0.02450727,0.020449452,-0.049367506,-0.031559244,-0.024787245,0.047265593,-0.016032564,-0.04005922,-0.010818465,0.044225577,-0.08069916,-0.015484619,0.067042194,-0.03439951,-0.06407384,0.008248751,0.031193191,-0.059473477,-0.03384577,0.0062516904,-0.052323055,-1.4949673e-33,0.12485069,-0.048385277,0.070751205,-0.06777559,-0.06814152,0.037826676,0.041988,-0.03620027,0.035827532,0.01928632,0.027498875,-0.032454938,0.02837837,-0.08862214,0.007057315,-0.015467707,0.0046966183,0.1349357,-0.02917342,0.025367431,-0.024861373,0.051880088,-0.024195846,0.06958507,0.060202386,-0.0066889017,-0.06072493,0.14258042,-0.081726745,0.1307824,-0.004092113,0.013512926,0.0011844209,-0.08086871,0.013109696,-0.0091911815,-0.047629893,-0.049551677,0.04455137,-0.0025687006,0.055255648,-0.014081888,0.08472024,0.046712358,0.020757312,0.03258873,-0.082672864,0.027887562,-0.0002214809,-0.050232336,0.027335975,-0.004722768,-0.0005063954,-0.015523742,0.009912578,0.056759737,0.050490513,0.020337531,-0.041681644,-0.019644747,-0.018477647,-0.010118735,0.013131576,0.045762703,0.035901204,-0.02602372,-0.011280487,-0.035181247,0.0071664117,0.010314142,0.011847987,0.036220774,0.04869949,0.041400164,0.056452285,-0.06513537,-0.068874754,-0.018397694,0.021485114,-0.069672816,-0.061868455,0.0033500502,-0.015467723,-0.14504541,0.021776624,0.020707134,-0.011122822,0.061262198,-0.024570575,0.0025872835,-0.045427915,-0.00431026,-0.042754646,0.06184252,0.002091777,-2.3178684e-08,0.08598443,-0.07275735,-0.0009578701,-0.054886673,-0.03958034,0.025869304,0.013825484,0.015490207,-0.027153729,0.046502165,0.024063524,0.06047468,-0.017019628,-0.063469544,0.07863451,-0.010029359,-0.008752474,0.05840007,-0.06744598,-0.10955139,0.02221877,0.004556649,-0.059351288,0.023101015,0.045738418,0.00019452395,0.033377975,0.07342274,-0.004238012,-0.035710435,0.028387591,-0.023591371,-0.04174474,-0.07680314,0.0035645496,0.0056740902,-0.05094888,-0.064086415,0.002519693,0.096912585,-0.010686697,-0.043281484,-0.08546205,0.010383399,0.00771628,0.0685161,0.028019218,-0.023037685,-0.018639045,0.0055156974,0.03725233,0.03523847,-0.031705733,-0.013754157,-0.109514736,0.020735232,0.039185364,-0.033391204,-0.02482407,-0.051115934,0.1285955,0.05319636,0.16639271,-0.07276852 +2.7.12.2,"This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.",384,1.0,-0.0065471316,0.0077670403,-0.069119655,0.021552868,0.12379734,0.019340057,0.0024571645,0.0889862,0.014114388,0.058238614,-0.017997703,-0.05304825,-0.0015223626,0.019879434,-0.024131585,0.091993116,-0.06033677,0.060028803,-0.019196369,-0.0465482,-0.013658743,-0.022434916,0.0090196915,-0.0040277466,-0.03356533,-0.030039024,0.018071724,0.07799881,-0.05025742,-0.03507957,0.010572196,-0.041352935,0.0026015788,0.006230601,0.0018461526,0.09970435,-0.06065325,-0.09844965,-0.10985449,-0.051938843,0.013850448,-0.060356088,-0.022191683,0.0035600285,0.103212304,0.026160387,0.0018494522,0.05452944,0.052903146,0.035898674,0.010051463,0.0008441794,-0.003017625,0.042827122,0.027904345,0.006981533,-0.13066226,0.023839846,0.02398548,-0.0066090575,-0.08326418,-0.039401934,0.07514547,-0.006619475,0.019623462,-0.008094318,-0.050493404,0.0051848157,-0.015373452,0.018961681,-0.04438918,-0.049794883,0.06579089,0.026912348,-0.02458736,0.034344975,-0.058362454,0.048599057,0.051799018,-0.043569457,0.0018328629,-0.049847238,0.02206898,0.024872746,-0.044191778,0.025256159,0.0058389283,-0.031264137,0.018582331,0.13704497,0.05092379,-0.012755691,0.038777433,0.06103611,-0.0014536198,0.0022166846,-0.024834763,0.01726899,-0.08417201,0.00505235,-0.041771714,-0.0076473393,-0.10898954,-0.03594821,-0.031037364,-0.05889973,0.03214633,0.015227767,-0.033682372,0.008506728,-0.018792886,-0.0041913353,0.034605075,-0.022066914,0.054678258,0.123261295,0.018227782,-0.054030444,0.05544072,0.037157625,-0.030962659,-0.034696385,-0.02898479,-0.03376844,-0.083224535,0.044137947,-0.028966201,3.511249e-33,0.020830313,0.054362856,0.069640145,-0.009570089,-0.010219511,-0.0784597,-0.004096027,-0.08618703,-0.035113312,-0.10740105,-0.017964046,0.0044281585,0.0215559,0.03442508,-0.04451405,-0.013178082,0.031967107,-0.0048048203,0.01663158,-0.01650105,0.025609363,-0.023220157,0.0073627913,-0.042335145,0.0012439424,0.038941737,-0.056478128,0.023358747,-0.04623335,0.03724685,-0.0721281,0.0011152918,0.0041388175,-0.018127494,-0.04798871,-0.04248813,-0.009982952,-0.018928412,0.0007615879,0.038517755,-0.005227095,-0.07482829,-0.082478985,-0.011525896,0.024715222,-0.087487996,-0.023298865,0.08036416,0.0047746976,-0.0036310703,0.055271823,-0.037132222,0.058570705,-0.03609473,0.019752137,0.04429016,-0.10440477,-0.056951687,0.039931163,0.02701008,-0.067619264,-0.07704005,0.013570887,0.110783376,0.022874108,-0.010209079,-0.13137697,-0.043343704,-0.07075014,0.069262676,-0.026868282,0.020213913,0.10482781,0.00065724645,-0.04110955,0.046773523,-0.030791828,0.06916226,-0.13059093,0.116774194,0.028877027,0.00625238,-0.046421748,0.0045877965,0.0010118613,-0.022528624,-0.0037097076,-0.059352405,0.047796104,-0.011351312,0.00033041718,-0.015075992,-0.047617204,0.056942698,0.007039788,-5.2900618e-33,0.039369445,0.0059775803,0.011244838,-0.040801365,0.001265311,0.13218509,0.09666801,-0.061523408,0.08233175,0.050390806,-0.007996193,-0.0029138832,0.0014397083,-0.048156947,-0.045205,-0.09133576,-0.027166195,0.12946334,0.05242051,-0.05203717,-0.01008944,0.061482716,-0.038673107,0.08534975,0.038195133,-0.010645348,-0.111341834,0.07291305,-0.08062327,0.10339524,0.03354198,0.040325236,0.012642555,0.008943342,0.0970834,-0.02585182,-0.030573336,-0.042747077,-0.0073094754,0.013376638,-0.020522127,0.015229091,0.0068203253,-0.033346947,0.03217022,0.050536066,0.031601015,0.052549005,0.046386823,-0.056598406,-0.018523216,-0.019594438,-0.045584496,0.050584596,0.041762613,0.06879562,0.005428017,0.054948978,0.093335934,0.054600134,-0.06491655,-0.07874452,0.058268137,0.024481922,0.075408824,-0.02533944,0.026850991,-0.032252457,0.017151557,0.056221917,0.046594962,0.039023153,0.014142895,0.028685315,-0.037619885,0.025492191,-0.0101376865,0.024030799,-0.074033014,-0.056412384,-0.04679604,-0.037789855,0.009737075,-0.029075053,-0.056707278,0.08485095,-0.006694577,0.009781085,-0.0016062028,-0.045459025,-0.041260008,-0.06377016,-0.15838546,0.08663241,-0.061183117,-4.966681e-08,-9.771506e-05,-0.020241022,-0.03097147,-0.055906333,0.0017273269,0.03587778,0.07378794,0.038620982,-0.0029483268,-0.030532729,0.017835375,0.027784558,0.1061325,-0.06807032,0.016819395,0.025089242,0.05458067,0.068048455,-0.0002965409,-0.028426984,0.03522582,-0.08948211,0.05662621,0.029677304,0.04933738,-0.07079269,0.029240156,0.07325145,0.03531728,-0.08567235,0.017318185,-0.08144901,0.07262713,-0.0059135156,-0.060707513,0.10342723,-0.06007868,-0.059414368,-0.017257296,0.07905973,-0.017128328,0.015663669,0.041080203,-0.053385723,-0.07009889,0.048268646,0.100252934,-0.022544662,-0.0558194,-0.054413155,-0.056807496,0.02503025,-0.027562665,-0.03596781,-0.017107807,0.05183924,-0.05337323,-0.016707905,0.07962604,-0.09367595,0.05595703,0.0023550938,0.016082972,-0.02789635 +1.1.1.289,"The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.",384,1.0,-0.03066176,-0.020384017,-0.0325661,-0.03980957,0.031127026,-0.01675243,-0.14184314,0.025874948,0.05636861,0.09375025,0.0077726566,-0.020566637,-0.06959007,-0.02335936,-0.028493632,-0.018204646,-0.03327162,0.021809598,-0.047838427,-0.033965997,0.0679968,-0.00030148236,0.02503568,-0.027525386,0.038734794,0.027278814,0.057177864,0.0033669134,-0.033330154,-0.12777317,-0.016377559,-0.008279025,-0.0047313147,-0.026407711,0.008391335,0.073119916,0.019168241,0.05105103,0.07096715,0.00073119544,-0.027210409,-0.017258449,0.027791424,-0.0015854555,-0.07073933,-0.04474308,-0.15276305,0.10886181,0.04338311,0.027965678,-0.0319963,-0.021337524,-0.005877998,0.046954334,0.024126217,0.114065,0.03884994,0.0038670253,-0.012327899,0.017542332,0.015270795,-0.03204005,-0.03688886,-0.0093897125,0.06610844,-0.065733574,0.0024772272,-0.072040774,0.0139426645,-0.028765803,-0.0062631313,-0.071458295,-0.04487417,-0.0010026585,0.020730067,-0.021008499,-0.012072088,-0.023020513,0.04915152,-0.005167536,0.08776267,0.040099766,0.066652246,0.04374914,-0.009609178,-0.026460204,-0.01986976,-0.041286077,0.072836556,0.021979563,-0.05953752,-0.05731276,-0.04127667,-0.03527119,-0.02852962,0.025976654,0.016027594,0.04746407,0.053901397,-0.049289137,0.024570363,0.021189421,-0.040767953,-0.081635356,-0.08470395,-0.011106456,-0.036162388,0.09672434,-0.052853305,-0.04727474,0.050142903,0.017612468,0.08422424,0.058345523,-0.092614055,0.009738212,0.00976463,-0.08367389,-0.052380927,-0.07385854,0.0064438772,0.027060587,0.039692182,0.087591186,-0.0046572275,0.062722676,-0.08583756,-5.577664e-34,0.06773286,-0.02131188,0.029132586,-0.056528218,0.014269021,-0.022407496,-0.07076252,0.031442422,-0.063882545,0.04281954,-0.08536143,-0.047627207,0.027214361,0.014509373,-0.08707363,-0.014754159,-0.013532075,0.017111257,-0.057835303,-0.018985283,0.032337364,0.12677321,-0.036735043,-0.017232515,0.01649721,0.09361177,-0.034455754,0.06706592,0.027404875,0.00885376,0.011691782,-0.059657317,-0.047220066,-0.0025063683,0.049186334,0.06292568,-0.05292413,0.0140593555,0.019914087,0.07533649,-0.008297661,-0.010828386,-0.051284436,-0.051874757,-0.0075023063,-0.015063087,0.021996263,0.02584207,0.007150255,0.0869602,0.07859861,-0.028070671,0.016438749,0.007522374,-0.07541029,0.030433286,-0.029011799,-0.023192815,0.067589015,0.13084991,-0.02404136,0.058262885,-0.041194867,0.019233765,-0.0015556858,-0.065812856,-0.026108475,-0.01646873,-0.0090002,0.05177503,-0.036333244,0.0070856106,0.07467517,-0.024267036,0.063524276,-0.02230098,-0.051549744,0.019224005,0.016723258,-0.047739957,0.0040352303,0.019144204,-0.042360038,-0.0529736,-0.050766848,-0.002039526,-0.09710461,-0.13887845,-0.05345004,0.07737877,-0.030209728,-0.055490606,-0.040555693,0.06752843,0.09057569,-1.8371305e-33,0.055758756,-0.09103579,0.03321166,-0.050898302,-0.042151697,0.08321514,0.065081,-0.0016914475,0.081171185,-0.016932728,0.059197836,-0.019204883,-0.07161428,0.019976215,0.023409061,0.040963072,-0.010600473,0.06413298,-0.0061249826,0.0081803,-0.0045024944,0.113216594,0.007168642,0.045870613,0.091828816,0.0029352927,0.032938078,0.08938833,0.056799807,0.04078818,-6.46471e-05,-0.007428677,0.03901396,0.025293795,-0.05660881,0.044368513,-0.13084383,0.0110791065,0.006409463,0.033053644,-0.090151615,0.036679942,0.05699289,0.015440333,0.02696673,0.024983542,-0.10341152,-0.027566921,0.016098445,-0.031110153,0.025337903,0.0052868556,-0.0009737415,0.0454944,0.0018879063,0.042084303,0.016859611,0.029089931,-0.0044114557,0.033639897,-0.036758795,-0.08899391,0.103222646,-0.05487426,0.07216044,0.04508654,-0.053414382,0.027940152,0.05240261,0.0050002118,0.07264533,0.043895155,-0.017690197,0.034745455,0.021707587,-0.099794075,-0.11208952,0.013269939,0.018808175,-0.007980979,-0.06379359,0.009055046,0.0031554482,-0.036596324,-0.056158807,-0.106917314,0.010179036,0.041604377,-0.007252062,0.07939228,-0.04791999,-0.008292373,0.009471068,0.037425295,0.12889117,-2.7142711e-08,0.018783392,-0.090452746,0.04092353,0.03430216,0.04621422,0.055835824,0.020037403,0.058051944,-0.007558172,-0.046291236,-0.07841272,0.16585438,0.03625441,0.012111634,0.020907667,0.024070632,-0.032258112,-0.033558786,-0.00622818,-0.012269625,-0.07059161,-0.010392869,-0.07941368,0.0156111885,-0.03972062,-9.664719e-06,0.044867538,0.029217241,-0.004734114,-0.028330997,-0.017284814,0.038818713,-0.039452948,-0.07037292,-0.05517143,0.025847511,-0.0528761,-0.04024084,0.011916145,-0.014219002,0.0015502283,0.027290916,-0.01443722,0.008691462,-0.0630874,-0.0043400517,0.008238093,0.009704764,-0.014671328,0.055893634,-0.0034953456,-0.012598494,-0.034532033,-0.044283118,-0.07711567,0.031211045,-0.052711815,-0.09938078,-0.03121356,0.02734076,0.0713775,0.03045879,0.17384017,-0.031185394 +1.1.1.290,"This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid [6]. cf. EC 1.1.1.399, 2-oxoglutarate reductase.",384,0.99999994,-0.037203413,0.006870393,-0.090560205,-0.019239279,0.054187514,0.039616022,-0.067614585,0.0037879392,-0.012475949,0.008804215,-0.013912488,0.04248929,-0.07483984,0.017651424,-0.05495231,0.04785591,-0.076032296,-0.0073353266,0.0048668724,-0.06776376,0.099161685,0.010802469,0.00037654006,-0.005115023,0.038185373,0.0375747,0.049469333,-0.006789611,-0.06947935,-0.08497424,-0.042146396,-0.018358514,-0.00857014,-0.10523094,0.034064647,0.10639994,-0.048546553,-0.05458823,0.016916724,0.045324128,0.009925289,-0.022639183,-0.05031776,0.00025359044,-0.041632496,-0.023765532,0.027496707,0.06537359,0.040253084,-0.028949307,-0.09936407,0.0243884,-0.06712806,-0.023031717,0.045497917,0.013225306,0.022911275,-0.031213611,-0.012519971,-0.078165695,0.05878721,-0.05162964,-0.025022618,0.05376512,-0.019458305,-0.07425839,0.032541998,-0.1040934,-0.023443613,-0.05061808,-0.11816276,-0.042628232,0.055707045,-0.037696116,-0.00857975,-0.0097066285,-0.021002837,-0.044199802,0.028607018,0.038056433,0.06237291,-0.00095410907,-0.022851797,0.07357536,0.03975294,0.004101977,0.02034784,-0.051275373,0.06901274,0.01042562,0.011248964,-0.0018554725,0.036017068,0.007391447,-0.11148729,0.021040566,0.002735047,0.051131915,-0.01837961,-0.03142807,0.015928576,0.08909923,-0.0053744777,-0.08719932,-0.09011569,-0.0019237144,-0.015653476,0.1504373,0.055989698,0.021685671,-0.008408389,0.025185242,-0.01656533,0.028770812,-0.022390813,0.14074782,0.034030445,-0.04284924,-0.13455693,-0.02625197,0.05623043,-0.05112512,0.022352494,0.00092664367,-0.05482957,-0.0553522,-0.14044778,2.1983412e-33,0.07797692,0.049632736,-0.009782698,0.002647126,0.039937273,0.020342495,-0.13433853,-0.031643357,-0.008717263,0.025492668,-0.028422303,-0.035932392,0.041897923,0.00424047,-0.07961558,-0.044712003,-0.052932184,0.008474051,0.010751408,0.036082394,0.049637105,0.1163334,-0.03908427,0.031032769,-0.0014717564,0.088495314,0.015183561,0.010336969,-0.01580531,0.002819664,0.058449756,-0.099244334,-0.08443284,0.005893599,0.043034438,-0.08064363,-0.07000398,-0.03453311,0.0152377905,0.047688544,-0.060708307,0.040615175,-0.012335976,-0.022147832,0.050600573,-0.118041545,0.00016705782,0.1293672,0.021308554,0.11899362,0.016344208,-0.0055295434,0.09514723,-0.00075962255,-0.078976616,0.0040026074,-0.0333197,0.003878797,0.045636043,0.054740883,0.06377943,0.028124705,-0.021695424,0.03017956,-0.041707024,-0.007885158,0.017711706,-0.06805561,0.05517478,0.08392579,-0.027736308,0.044523314,0.073008075,0.03275297,0.023646174,-0.06537911,0.02764867,0.02602379,0.024732482,-0.021544954,8.80259e-05,-0.028107833,0.015504711,-0.0010995333,-0.026542138,0.021913348,-0.03173825,-0.022064416,-0.0252149,0.06022032,0.042509507,-0.08301029,-0.013680917,-0.019076457,0.053872798,-3.4075124e-33,0.12248131,-0.10097239,0.04953241,-0.13362116,-0.025529252,0.026085649,0.0801696,-0.005117764,-0.0071714697,-0.03450153,0.044408422,0.0584846,0.055047307,0.025598042,0.06442111,-0.030562138,0.03485406,0.043779314,-0.055364106,0.0024148244,0.06568985,0.0822015,0.0027869248,0.011013287,0.04749413,0.021048682,-0.023867154,0.027519617,0.023164328,0.008713211,-0.047838222,-0.03399087,-0.038289137,-0.04292008,-0.0009865572,0.039059106,-0.07610659,0.03196445,-0.035352174,0.05485407,0.026743846,0.022015465,-0.035280723,-0.0016760028,0.04172551,0.0063434555,-0.12000244,0.039988235,0.013413932,-0.06946968,0.023249945,0.0574886,-0.05536537,-0.02141063,0.0568559,0.026648313,-0.020099249,-0.01126193,0.005194239,0.013021164,-0.05350574,-0.0562109,0.03365033,0.047835164,0.06941675,0.048762806,0.050833948,0.032612108,0.012753872,0.061713994,0.08858725,0.025344387,0.0147616165,0.044545256,-0.0031331633,-0.062750004,-0.08415473,-0.0049365875,-0.004310268,0.02385202,0.0134690255,-0.052275416,0.0136708915,-0.09103559,0.004476946,-0.09761415,0.033043534,0.09196025,0.008153547,0.025826873,0.0012449427,-0.0030796207,-0.0012735192,0.034625173,0.042553518,-3.632507e-08,0.0015250866,-0.064160734,0.06402883,9.011035e-05,0.05888859,0.048609823,0.0072019435,-0.009282201,0.06960447,-0.027993154,0.03545874,0.082518764,0.055337325,0.015807716,-0.00541063,0.027869578,-0.06506892,0.02713715,0.002423279,-0.036645096,-0.06368775,-0.023048267,-0.1265677,0.05121855,0.049536545,-0.04421525,0.03473088,0.004209913,-0.019885655,-0.079357944,-0.00047696425,0.046439048,0.05570717,-0.051316444,-0.118326694,0.017736405,-0.013377291,0.02556016,-0.040819366,-0.01044308,-0.028885182,-0.061505836,0.02391362,0.038266398,0.009336457,0.045331016,-0.013663319,-0.051228132,-0.03171497,-0.01929702,0.040306162,0.0072717587,-0.025017414,-0.0690781,-0.12238851,0.02139437,0.005218249,-0.04557257,-0.0354973,-0.054530025,0.04029509,0.034207,0.1340893,-0.044345222 +1.2.1.71,"This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].",384,1.0,-0.0394668,-0.06258286,-0.114201136,-0.030330736,0.023057258,0.051100746,-0.012487927,-0.0063798698,-0.012860526,0.022964794,0.03262476,-0.06693283,0.0011482039,0.0086125545,-0.0937408,0.008166897,-0.11002523,-0.058715045,-0.028128468,-0.07150367,0.048299577,0.088896066,-0.06383352,-0.07440862,0.11029139,0.019911623,0.011043523,-0.071669444,-0.009436978,-0.084398955,0.0059378375,-0.09885321,0.021982174,-0.00908943,0.091819815,0.05642974,-0.07615923,-0.055387497,0.11229252,0.014322961,0.015235299,-0.02231187,-0.056429576,-0.06888824,-0.032148797,0.0156701,0.029342437,-0.023151552,0.007714421,-0.020956455,-0.03417492,-0.020702813,-0.0026074932,0.027976751,-0.017424157,0.023052702,-0.114080235,-0.05063786,-0.0133406045,0.034014136,-0.019581286,-0.0010248347,-0.023986878,-0.065193556,0.0513356,-0.024648944,0.06919828,-0.09292628,0.056060966,-0.029047567,-0.051025532,-0.07583339,-0.04395493,0.038710512,-0.030559128,-0.0065499125,0.035321847,-0.010153561,0.008978819,-0.06715895,0.056948207,0.07363673,0.0964532,0.053256705,0.008232057,-0.008990182,-0.027026618,0.022987554,0.04750123,0.060077265,0.024860201,-0.048653554,0.026617553,-0.014746442,-0.035160653,0.03500083,0.009829117,0.034071386,0.05728599,-0.04535136,0.011586661,0.060811404,-0.02758996,-0.084009856,-0.021242479,0.02291445,0.05405925,0.10252207,0.003000291,0.009277471,0.014327566,0.015895385,0.0008306159,-0.02171068,-0.0033962391,0.1098939,0.0483172,-0.051043876,-0.07280709,0.035682824,-0.034395922,0.07538052,0.11951429,0.08105361,-0.0672066,0.088142954,-0.11229054,6.444862e-33,0.041902747,0.011296295,0.031343553,-0.010249283,0.024727108,-0.010494392,-0.11306949,0.09550329,0.018611904,-0.03447805,-0.06876288,-0.05937074,0.06592573,-0.041207206,-0.01694745,-0.030837627,-0.03762496,-0.030455815,0.03426959,-0.021969091,-0.034583192,0.07197339,-0.020545743,0.04226554,-0.0003714037,0.0031419822,0.015263971,0.04895389,0.03123657,-0.006002312,0.011884492,-0.08524856,-0.098937064,-0.029072814,0.017709225,-0.04711642,0.008628573,0.02108102,-0.0020065145,0.110872395,-0.0032976572,0.036204416,-0.043588556,-0.032934804,0.057832524,-0.019958934,-0.028114244,0.11321857,0.03941253,0.08960172,0.016433012,-0.021306403,0.12645599,-0.014095395,-0.057345826,0.020277398,-0.012798877,-0.005501338,0.06906271,0.078797214,0.018404564,0.016130704,-0.009352403,0.029901981,-0.0007088645,0.052121654,-0.078899965,-0.09045532,0.024284935,0.07878249,-0.12144507,-0.019815583,0.06895713,0.00946767,0.05790198,-0.035968095,-0.05869976,0.0510881,-0.0026871038,0.019994814,-0.055591833,0.032843936,0.057392053,-0.0200505,0.010230638,-0.03201909,0.023148682,-0.10373706,-0.013527153,0.03781687,0.025556812,-0.037296955,-0.090616636,-0.0023671142,0.039826743,-5.6351612e-33,0.17079398,-0.062009286,0.00085927994,-0.061444297,-0.09648594,0.060667586,0.028368495,-0.0059004663,-0.0018810643,0.0038207616,0.1168997,0.06598908,0.09991486,0.0036572625,0.044336237,-0.05034421,-0.0059019113,0.050416876,0.027661527,0.03776293,0.022809291,0.08199658,-0.051131807,-0.009180508,0.044000056,0.021694664,0.0092131505,0.009370447,0.026162783,0.013725608,-0.026164401,-0.021343105,-0.011291554,-0.022768313,-0.07527411,0.030785117,0.019696955,0.03425618,-0.116534024,-0.009231921,-0.05961478,0.039321214,0.010905472,0.049839433,-0.004141787,0.049347542,-0.07363191,-0.018866481,-0.09238106,-0.05734621,0.054883037,-0.031561226,0.017350221,-0.010887791,-0.0016045683,-0.037205968,0.039180975,0.02012098,-0.0010842812,-0.024442622,0.0016736282,-0.022565456,0.033099227,-0.058136553,0.102875836,0.004690319,-0.026493499,0.035219483,0.013649785,-0.031263884,0.0016810778,-0.040840905,0.05648554,0.031750858,-0.008894242,0.004523607,0.007119866,-0.05596968,-8.472121e-05,-0.09600447,-0.0055893017,-0.04466382,-0.025507124,-0.024261752,-0.049486727,-0.022138992,0.0704097,0.11608936,0.018895237,0.07291368,-0.054369763,0.005640847,-0.030549577,0.06407463,0.082987614,-5.0546912e-08,0.007963172,-0.03389799,-0.030802336,0.019515963,0.038659528,0.09172854,-0.02564348,-0.0130941365,0.042658113,-0.030850973,-0.016218798,0.09155442,0.020381864,0.046527643,-0.0057822783,-0.0116652865,-0.04271544,0.008558037,0.021739533,-0.018180132,-0.102266304,0.012027018,-0.08508529,0.031136876,0.063392445,-0.10673981,0.054175712,0.040034015,-0.036045186,-0.06842304,-0.01804952,0.017363453,0.06590195,-0.06727814,-0.03780164,0.0019004755,0.009747144,-0.04845325,-0.0043621967,0.043845713,0.0052614086,0.029957782,-0.042197146,-0.0063307323,-0.037912916,0.027134215,-0.0024903151,0.023062436,0.018237459,-0.04594531,0.014490448,-0.019561684,0.024319375,-0.029348595,-0.09268226,0.010298943,-0.06467171,-0.08489372,0.027778776,0.017940935,0.05128105,0.052171424,0.118034385,-0.039167132 +1.2.1.72,"This enzyme was originally thought to be a glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12), but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate [1,2]. Forms part of the pyridoxal-5'-phosphate cofactor biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (pyridoxamine-phosphate oxidase). ",384,0.99999994,-0.024864458,-0.043159608,-0.08593303,-0.07042972,0.040217966,0.011780162,-0.086613275,0.021126043,0.017771175,0.020215089,0.0222053,-0.0071594613,-0.08574422,0.034264535,-0.020178892,-0.05421607,-0.047865942,-0.0015221691,0.023984052,-0.075720504,0.14002645,0.059813205,-0.017340839,-0.008319886,0.023079673,0.04034,0.054942038,-0.016830683,-0.006448161,-0.0482909,-0.07054939,-0.092195325,0.02579458,-0.07812161,0.05319842,0.13171086,-0.057819318,-0.06927082,0.08788914,0.035663255,0.04025367,-0.026239213,-0.034777127,-0.01120743,-0.0229945,-0.031138085,0.01644882,0.014840356,-0.01682735,-0.0408345,-0.050108008,-0.0049115964,-0.006287221,-0.03723058,0.04618559,-0.0072624683,0.0027894522,0.025666693,-0.03502544,-0.009281245,0.0047520217,-0.03782263,0.062400933,-0.0020738794,-0.032663893,-0.01917431,0.0567667,-0.08286334,-0.046767395,-0.06647134,-0.07958242,-0.035436537,0.074199066,0.027698046,-0.037239023,0.10677729,-0.02366504,0.030317776,-0.04026313,0.006801473,0.07343101,-0.04290155,0.0012291955,0.051962208,0.017595062,-0.046604753,-0.015667431,0.004118659,0.0030512721,0.03009701,0.034874376,-0.002487802,0.05126615,-0.0024769388,0.041488063,0.057782907,-0.055982783,0.06909862,0.0089412425,-0.11766131,-0.042373195,0.095935464,-0.029913876,0.024128916,-0.033852022,0.010382194,-0.0066162483,0.1371131,0.005996042,0.0038604378,-0.057240125,0.015768444,0.010227174,-0.025709925,-0.008330974,0.07441358,0.010002977,-0.043856695,-0.019629331,0.07439482,0.072700925,-0.06864636,0.054776475,0.06626703,-0.041121174,-0.004546845,-0.10039093,5.2605587e-33,0.07955123,0.119510435,0.028434807,-0.04184763,0.017950153,-0.0010912091,-0.09177846,-0.010683135,-0.07711176,-0.03728112,-0.024101393,-0.017980639,0.08165811,-0.0020890972,-0.02778303,0.008549582,-0.074551195,0.01070209,0.069622055,0.011363436,0.08052394,0.05662981,-0.021901492,0.030665766,-0.003747161,0.06554962,-0.04882521,-0.009686038,-0.0027773792,-0.005864246,-0.010326335,-0.12890519,-0.048251707,-0.023939248,0.050101064,-0.101963,-0.049714494,-0.046624545,-0.043664195,0.04059791,-0.018482009,-0.013972665,0.019642316,-0.011698656,0.049929727,-0.07254938,-0.0413975,0.04612927,0.04269136,0.1221715,0.01196795,0.009996444,0.1389293,-0.03367973,-0.08141747,-0.03472353,-0.023223246,-0.001134032,0.0445155,0.05801566,0.016281748,0.08107513,-0.02455406,-0.0069395327,0.008164704,-0.0056546214,-0.03946309,-0.07150576,0.008463804,0.10754389,-0.030795945,-0.0051036254,0.023925327,0.045264374,0.014115549,-0.049820416,-0.022914564,0.06380029,-0.04655978,-0.016776137,-0.016403088,0.029583426,0.0042363512,-0.016002065,-0.014569439,0.05245386,-0.033751465,-0.037749916,0.0028693762,0.07680843,0.023413649,-0.08014809,-0.033348564,0.0028892425,-0.052867435,-5.1030763e-33,0.12018662,-0.039449267,0.021717058,-0.086818054,-0.062234607,0.061955824,0.025033507,0.026122496,0.047414463,-0.019360688,0.03477012,0.049629755,0.048775673,-0.050251342,-0.016310025,0.030346228,0.014423257,0.025149878,0.016887013,-0.017869031,0.10563363,0.05137696,-0.022187619,0.042839542,0.09279011,0.07628797,0.020646522,0.016736908,0.008339145,0.020630311,-0.056240566,0.04080145,0.015361322,-0.03294547,-0.08384157,0.039338764,-0.12402299,0.0132018775,0.028682392,0.010208382,0.001213996,0.078934215,0.038626865,0.00409179,0.012336257,0.068070926,-0.033316806,0.059963662,0.015473313,-0.026874634,-0.05330913,0.044498216,-0.040353883,0.034677077,0.04449706,0.00265449,-0.028588858,0.076477125,-0.021050973,0.0069139875,0.014940533,-0.037597388,0.055697437,0.014471146,0.066690356,0.026483113,-0.014381203,0.033259876,0.009310603,0.06504666,-0.015231083,0.019943852,-0.0094536515,0.048442498,-0.0018781648,0.015491031,-0.101834305,0.0321949,0.01115629,0.034333352,0.049315695,-0.00783741,0.002216295,-0.055244505,0.016882949,-0.06283533,0.040515088,0.14490385,0.047064602,0.008537459,-0.02423223,-0.04994457,-0.05739083,0.031636234,0.039309714,-5.1141214e-08,0.06955324,-0.056118116,0.030689219,-0.069454126,0.025444852,0.011844678,0.039992023,-0.025938872,0.05562097,-0.04950641,0.00353946,0.0024747057,0.014313002,-0.034988463,0.03251869,0.010644241,-0.0875957,0.006120253,0.015919685,0.014934946,-0.06537528,-0.053867903,-0.15330817,0.027809156,0.07109318,-0.02565094,-0.005688499,-0.04224112,-0.009141297,-0.025141468,-0.002762388,-0.0002586225,0.057224672,-0.056332465,-0.07773438,0.003158094,-0.07313965,0.002006537,-0.06386704,0.01463995,-0.018354675,-0.073583916,-0.0184508,0.0332034,0.018573344,0.09554244,-0.03351004,0.015838105,-0.051408567,-0.09334889,0.050874494,-0.052070647,-0.031573847,-0.070020854,-0.13029504,0.0022250712,0.0113650635,-0.093953714,-0.012126174,-0.07687002,0.014119214,0.01596665,0.19889338,-0.010252153 +1.7.1.13,"The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queuosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, tRNA-guanosine34 transglycosylase. Queuosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies.",384,1.0,-0.09341388,-0.052494317,-0.111311175,-0.0020597824,-0.039288916,0.0014560389,0.0069635375,0.048888505,0.059510928,0.021151515,0.07069758,-0.03199061,-0.03773806,0.041014668,-0.05866495,0.015168378,-0.08178481,-0.055550076,0.053830385,-0.10264744,0.021636233,0.03218907,-0.046355385,-0.0028054612,0.02460594,0.0014954034,0.027883604,-0.042610172,-0.0028499586,-0.019770583,-0.063998826,-0.00747127,-0.020321583,-0.025959516,0.016898809,0.04847119,-0.061114103,-0.06330691,0.069598064,-0.0021997767,0.015624286,-0.019135697,-0.038162775,-0.033366118,0.025772432,0.001133009,0.054588143,0.09084257,0.0007362483,-0.030320885,-0.024796285,-0.029547129,-0.04585167,0.034890153,-0.011213799,0.015222909,-0.041609664,0.015861653,0.013410486,0.06970739,0.0647976,0.084917195,0.0004946833,-0.030213105,0.01374037,-0.096194506,0.041747466,-0.031428102,0.08141396,0.0034815166,-0.069811665,-0.020636382,-0.02059497,0.04281957,-0.025471147,0.05599882,-0.023905054,-0.013285341,-0.015136406,0.032270696,0.07597604,-0.048852257,0.07245815,0.034911335,0.05221165,-0.029306097,0.02324803,-0.0076493863,0.07560201,0.046210106,0.06487088,0.0065621953,0.015793312,-0.047072094,-0.07377784,0.04978467,0.009669114,0.040267847,0.06084907,-0.0511959,0.04195231,-0.025696,0.06712578,-0.03133894,-0.05079706,0.031840023,0.060868565,0.039470818,0.025378844,-0.013173076,-0.038092624,-0.001734259,0.07514749,-0.019023428,-0.030423786,0.112588115,-0.0048375223,0.002028474,-0.08273768,0.010007548,-0.023546489,0.0339733,-0.030017031,0.03417613,-0.0077626854,0.03557633,-0.10845556,1.2662419e-33,0.066686586,0.08502964,0.024718039,-0.04771185,0.005148987,-0.039257143,-0.054428235,0.029678436,-0.088968255,0.029955707,-0.026625369,-0.08229818,-0.0054274974,0.0046162303,-0.03963066,0.019986158,-0.06175911,-0.021847902,0.026264124,-0.0069275484,-0.0018498404,0.044424362,-0.062811665,-0.0058126873,0.025875049,0.08023493,-0.04549628,-0.009895712,0.03146314,-0.015603674,-0.07127168,-0.07441568,-0.13212767,-0.032635283,0.074415475,-0.055573992,-0.020537084,-0.036151227,-0.05055506,-0.005262541,0.0063411384,-0.0051069986,-0.01674232,-0.06721357,0.005253194,0.0001781049,-0.022501614,0.0061994283,0.064066075,-0.019191604,0.036360685,-0.058326494,0.012178708,0.061583396,0.03907829,0.0282233,0.035545126,-0.041208275,0.0613654,0.044170078,0.022079477,0.03193521,-0.035935476,-0.031448286,-0.06916139,0.022533052,-0.062160008,-0.077518046,-0.0016951135,0.07661119,-0.016079795,-0.10638368,0.08847699,0.006338771,0.09993492,-0.0716484,-0.06783128,-0.022230124,0.018754415,-0.0023059447,-0.0527051,-0.07288327,0.00033564758,-0.010798152,-0.049664706,-0.016786603,0.038988344,-0.053608883,0.008955629,0.1121344,-0.009316428,-0.04829471,-0.029825747,0.077500015,0.03805566,-2.1717423e-33,0.05213526,-0.07828584,0.0058872737,-0.06856752,-0.087760516,0.03957525,-0.025371341,-0.08771136,0.054047596,-0.052046802,0.08234522,0.006352238,-0.00014117984,0.016356392,0.039505083,-0.04545912,0.07916815,0.018568775,-0.035035644,-0.016467273,-0.034858115,-0.0112004755,0.016413203,0.0057797865,0.06925579,-0.003020693,0.11567008,0.058661778,0.016583377,0.070168965,-0.105483025,-0.09201469,-0.005460792,0.024598537,-0.05173527,-0.0022745105,0.025088912,0.0057710446,0.007020143,-0.028581414,0.0356726,0.019971183,0.064408086,0.13652521,-0.00088262936,0.081016146,-0.06140201,-0.016817885,-0.018809965,-0.053179312,0.126643,0.113505594,-0.0031041799,0.015160074,0.015972285,0.054832112,-0.013780329,0.010776953,0.0034686478,-0.045528714,-0.044444382,-0.094494775,-0.014416943,-0.092419654,0.10530631,0.053599924,-0.035510898,0.11359689,0.07118368,-0.0483802,0.015901592,-0.015775708,0.028758125,0.050544884,-0.04388891,-0.03923198,-0.02463746,-0.07626595,0.057476766,-0.09207891,0.0052333414,-0.03494805,0.03739856,-0.059127696,-0.054987658,-0.061764073,-0.0027473003,0.12958436,0.045095302,0.06546721,0.007442102,-0.0029579408,-0.0075157015,0.05884682,0.081225015,-3.9416026e-08,-0.07983339,-0.05220467,-0.016314026,-0.011748746,0.0084669385,0.076485254,0.0056984215,0.067606725,0.049851466,-0.02559935,-0.009752227,0.10037648,0.03077285,0.06929245,0.026640505,0.05229325,-0.073906615,-0.00024355124,0.016469494,-0.041758265,-0.05160211,0.01845473,-0.15837905,-0.006622171,-0.06220068,-0.0051867515,0.02709269,0.069620356,-0.027654488,-0.042880967,-0.030127143,-0.0078101703,-0.014647819,0.04554134,-0.025404727,-0.037044108,-0.043845743,-0.048020087,-0.028423604,-0.0014334361,0.041910656,0.09898884,-0.093410425,0.024198113,-0.058473345,0.032574914,0.054691516,0.03497257,0.008832303,0.04830096,0.046973616,-0.0005165485,0.053179935,-0.022035932,-0.041399952,-0.017409574,-0.0073293555,-0.046200626,-0.08506856,0.009448312,-0.019108895,-0.034004364,0.15792675,-0.013875509 +5.2.1.12,"The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.",384,1.0,-0.106456034,0.028362552,-0.081288785,-0.020016156,0.037716616,0.03345833,-0.06735587,0.064919725,0.02335444,-0.04428161,0.07901823,-0.091337144,-0.10991947,-0.015187991,-0.019527443,-0.004149997,-0.075035885,0.057750657,-0.053403452,-0.094464354,0.049979568,-0.007901902,-0.029560242,0.052716754,0.034334548,-0.03996481,0.013625521,-0.07204628,-0.029832643,-0.034060728,-0.03214655,-0.098469466,0.03604896,-0.05952526,0.044639204,-0.0056817094,0.01905349,-0.11881222,0.048263837,0.028033968,0.04328792,-0.060114853,-0.029775418,-0.036987454,-0.0030564792,-0.026709758,-0.005699007,0.068987176,-0.0073973574,-0.03944052,-0.04043811,-0.019122725,-0.087502144,-0.008822407,-0.0153111415,0.018133808,0.023093816,0.040572762,0.06485694,0.0731806,0.0799166,0.004608776,-0.02280585,-0.0026416625,0.028147064,-0.06842855,0.008925054,-0.0630318,-0.017486846,-0.030778935,-0.030550104,-0.06619486,-0.13089934,-0.05153851,-0.018094257,0.032054126,-0.050223224,-0.015488297,-0.010429543,0.01940108,0.032389298,0.025891913,0.036062498,0.07883579,0.047396436,0.028539991,-0.048703656,0.050310347,-0.0064809383,0.043012723,-0.011336842,-0.0078066667,0.009621366,0.047756836,-0.08466923,0.05436622,0.058054395,-0.025531437,0.024363916,-0.03132371,0.026062435,0.0498974,-0.057404924,-0.08256546,-0.07940458,0.039945256,-0.0007704027,0.05504394,0.04756344,-0.0025619501,0.03788386,0.036469396,0.031200774,-0.048920594,-0.050306007,0.10590872,-0.01591131,-0.07147085,0.021075644,0.041504126,-0.028073981,0.007182631,0.0048522567,0.05704273,-0.032926142,-0.013718302,-0.06939518,2.292555e-34,0.044232033,0.13588408,0.022023566,0.043757573,-0.07961381,0.0029937057,-0.105548956,-0.019309135,-0.10181783,-0.07216586,-0.10638011,-0.12034847,0.038861137,-0.043608196,-0.059105486,-0.043719884,0.03680701,0.003208856,0.032726996,-0.01864951,-0.0097333575,0.059393663,-0.06879729,0.08833139,0.04846741,0.078192584,-0.009133073,0.006545289,0.07103652,-0.0028498697,-0.03147071,-0.013041807,-0.05249315,-0.019263059,0.12754624,0.00036439678,0.031743687,-0.0077567007,-0.027728725,0.068999566,0.04517155,0.03877479,0.019722667,-0.027422776,0.11831514,0.003441286,-0.0011405537,0.045618426,0.08578701,0.025105903,-0.056598693,0.07769799,0.026649676,0.025705611,-0.07308424,0.05135019,0.03618543,0.005710316,0.018071493,0.041048847,0.014242265,0.062798776,-0.030362135,0.011238443,-0.010048905,0.08996146,-0.07065472,-0.047803763,0.05005486,0.04543771,-0.105154775,-0.03654244,0.070298396,0.017984454,0.07188316,-0.023663525,-0.06095028,0.0012662009,0.050971374,0.005489203,-0.108033545,0.03532768,0.048994876,-0.08461351,-0.012639947,-0.040924802,-0.028829334,0.015520437,0.009634067,0.072740115,0.047133323,-0.048136886,-0.026767366,-0.022256024,0.011786137,-8.175726e-34,0.0891572,-0.08734624,0.010648494,-0.06137679,-0.029394526,-0.007377811,-0.089035444,-0.21276389,0.0009365466,0.028955149,0.084163986,-0.012547418,0.05769307,-0.011146449,-0.012574804,0.020231195,0.023067903,0.09079936,-0.04291172,0.029157024,0.0026542943,0.025424657,-0.013117565,0.05134544,0.014403124,0.032582603,-0.01740172,0.0451276,0.13459933,-0.0017164563,0.013081165,-0.088864915,-0.06365966,-0.014030182,-0.019836579,0.082523674,-0.0490945,0.07717748,0.028802687,0.06923518,-0.078914076,-0.02915268,-0.017122077,0.047459565,-0.00050948176,0.058670092,-0.07624047,-0.022754792,-0.06776416,-0.016247293,0.06491186,0.019678587,-0.03900418,-0.0021439833,0.030086085,-0.044401266,0.030009095,0.06971205,-0.030271374,-0.014911296,0.01850816,-0.019456966,0.010982305,-0.070799775,0.032675132,0.043802697,-0.025043948,0.03798215,0.034496956,-0.011593136,0.05761648,0.06865837,0.058559578,0.021300722,-0.040502355,-0.06502941,0.022878908,-0.0391161,0.015949145,-0.04647066,-0.051982168,-0.024137868,0.035612486,-0.06197847,-0.0033010857,-0.022786645,0.025660478,0.077996716,0.037852407,0.057323113,-0.056073464,-0.012904778,0.011801657,0.05545004,0.09257943,-3.208938e-08,0.0044344203,-0.030618405,-0.01221307,-0.043811,0.007906571,0.016041426,-0.0298661,-0.043458797,0.044290695,-0.02268048,-0.01989712,0.016274381,0.053469986,0.0005628455,0.06329882,-0.04300425,0.048718534,0.052150015,0.01085997,0.059260838,-0.06116624,0.024403324,-0.089555874,-0.048557017,0.007912408,-0.09416637,0.019554788,0.015931904,0.023270257,0.054055527,0.077829175,0.019176245,0.0068301903,-0.012567215,-0.029614268,0.034530263,0.028341744,0.026446838,-0.0026277155,0.017035017,0.036601167,-0.022167157,-0.1283051,0.045617558,-0.03254987,-0.010052114,-0.0034748917,0.006777323,-0.02989692,0.067535825,0.001074242,-0.015870718,0.006848298,-0.013574023,-0.019563062,-0.006454408,0.045124114,0.009852703,-0.045851946,-0.010330844,0.034819055,0.021047352,0.14320992,-0.05732712 +1.11.1.16,"A hemoprotein. This ligninolytic peroxidase combines the substrate-specificity characteristics of the two other ligninolytic peroxidases, EC 1.11.1.13, manganese peroxidase and EC 1.11.1.14, lignin peroxidase. Unlike these two enzymes, it is also able to oxidize phenols, hydroquinones and both low- and high-redox-potential dyes, due to a hybrid molecular architecture that involves multiple binding sites for substrates [2,4].",384,1.0,-0.008305894,-0.07693118,-0.016187426,-0.018731186,0.11806142,0.048276275,0.023392158,0.049438022,0.032525826,-0.055858973,0.070382014,-0.0015678143,-0.046443507,-0.012975299,-0.05579336,0.13904163,-0.09172785,0.0033632473,-0.07695891,0.06653877,0.026729222,-0.030413453,-0.073222585,-0.011025619,0.04098022,0.0107433535,0.067012236,0.0011493318,-0.048342545,-0.062632516,0.032866925,-0.03405583,0.09198424,-0.036744367,0.026559353,0.052815925,-0.012958254,-0.107894555,-0.05804541,-0.039970998,0.009658607,-0.031072708,-0.013980194,-0.02674773,-0.019099526,-0.0024119725,0.1215053,-0.008711554,-0.017539382,0.017173877,0.012157285,-0.07811555,-0.08027968,-0.022069696,-0.0074290903,0.104670785,-0.03878156,0.05406815,-0.011432648,0.012581367,-0.047145665,0.013099578,0.046965707,-0.022921516,-0.0109179625,0.013585942,0.065616354,-0.047903545,-0.0022479233,-0.12841566,-0.0067565143,-0.027659936,0.0040095258,-0.00016625761,0.011969962,0.11823155,0.016455246,-0.01849637,0.047345072,-0.090136364,-0.03297626,0.037904155,0.036355197,0.10953385,0.060715705,-0.0014402173,-0.030666374,-0.001523018,-0.06092649,0.020420585,0.0039599766,0.023287674,-0.032273997,0.0055768574,-0.023583194,0.09249405,0.10718019,0.036087573,0.008568331,-0.06584333,0.008273046,0.080639936,0.017191663,-0.10571069,-0.04569218,0.026478857,-0.02729825,-0.006797833,0.060446933,-0.08648675,0.048877005,0.049954064,0.051851377,-0.017351449,0.027763186,0.09879716,0.036062587,-0.04731508,-0.021107584,0.042678986,-0.058398616,0.020815777,0.04890748,0.0075801914,-0.013477801,0.011934647,-0.022816816,1.8773875e-33,0.067753024,0.029987857,-0.016734276,0.013748768,0.0009703826,-0.007993267,-0.12237325,0.003001857,-0.028490044,-0.016067706,-0.028681543,-0.007082204,0.020160364,-0.0011988735,0.014276587,0.0038385054,0.0014444969,-0.0425884,0.039192803,0.024584567,-0.011996846,0.01571509,-0.105183415,-0.040302742,0.0006967429,0.04416527,0.069747865,-0.041477397,0.018895024,-0.008454006,0.022307439,-0.04807322,-0.078354396,-0.052837566,-0.01203239,0.009207613,-0.030842626,0.027723867,-0.06752531,-0.020624863,-0.029977769,0.052539136,-0.0601236,-0.0121240625,0.08081295,-0.081419386,-0.0823663,0.07633383,-0.011965319,0.04100317,-0.056017127,-0.0074909744,0.092002794,0.03301981,-0.0123084,-0.024581887,-0.016722988,-0.019851577,0.049431823,0.022981916,0.052126657,0.0953193,-0.08635702,0.04734958,0.069905214,0.05065897,-0.062246434,0.007829988,0.028612934,0.032709293,0.026827307,-0.01406048,0.03236311,-0.062277712,-0.055862885,-0.039700396,-0.070301525,0.013620184,0.092423506,0.035251543,-0.03199907,0.016926521,0.01698513,-0.08944851,-0.06759321,0.05762638,0.011252994,0.002181833,-0.06641243,-0.016369713,0.07878325,-0.03632034,0.026560813,-0.10697429,-0.012153282,-1.8384653e-33,0.0334378,-0.081619345,-0.03712691,-0.042888682,0.0629509,-0.041136887,0.031855527,0.016510405,-0.0034789336,-0.03719349,0.052937735,-0.0063728997,-0.002460537,0.0027432442,0.031072939,0.05866692,-0.06236678,0.1106796,0.061051544,0.0026278235,-0.0567053,0.036212053,0.00019774135,0.14303294,0.0189968,-0.01694643,-0.054294188,-0.0038944718,0.035583653,0.058770597,-0.018538658,0.034176774,0.04248617,0.023896955,-0.0038622178,-0.050785206,-0.10483691,0.005634205,0.06105069,0.051451966,0.046440728,-0.039313596,-0.0009523914,-0.016029397,-0.014496432,0.12092076,-0.16269058,0.030634545,0.042807944,-0.040431786,0.016150182,0.042701725,-0.064405285,-0.009458935,0.026811838,0.043828554,0.030099845,0.047919348,-0.013277739,-0.008062152,-0.09518218,-0.013476519,0.04435798,0.061840996,0.0028101979,0.1013267,-0.0041897553,0.07166461,-0.025206415,-0.08214764,0.07919402,0.0141893225,0.07757279,0.012697952,0.023309141,-0.093774326,0.026019245,0.036344644,0.019574024,-0.035335384,0.058891714,-0.01055229,0.005252629,-0.04459031,-0.030273557,-0.01655946,-0.029900128,0.06400863,0.0060669924,-0.055288058,0.01497606,0.018903865,-0.075157285,0.018370962,0.070222445,-4.0688313e-08,-0.029863425,-0.046478804,0.06618778,-0.03477047,-0.025605282,0.015833288,0.0700201,0.033076238,0.0279405,0.009071047,0.038082585,0.041196153,-0.07487296,-0.049206745,0.009233313,-0.0015291317,0.01665453,-0.0034829883,-0.024430973,0.04318736,-0.037198167,0.056104187,-0.10095079,0.0051944507,-0.011236761,-0.068096414,0.0068458836,-0.048380084,0.06398135,-0.036824685,0.029585356,0.065127365,-0.026864864,-0.04479037,-0.07350483,0.019811064,0.020560224,0.0033672694,-0.09188299,0.0040913033,-0.07275328,-0.09092546,-0.047420077,-0.065992825,0.04011049,-0.058809336,0.0661482,0.013089406,0.007898416,0.046106722,-0.019536199,-0.044818174,0.06415639,-0.0504462,-0.1054609,0.027510887,0.028110307,0.025474934,-0.04916688,-0.065198004,0.042504564,-0.040165305,0.16881582,-0.009966862 +1.13.11.52,"A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase [1]. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver [2]. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7].",384,0.99999994,-0.03488558,-0.011330964,-0.070941955,-0.0002743749,0.14097418,0.05128164,-0.06402195,0.085531436,0.0075095017,0.021739418,0.025690092,0.0070672915,-0.10412562,0.047031075,-0.019704081,0.11690694,-0.0014875085,-0.082128994,-0.030373216,0.001970163,0.010914157,0.04082592,0.016408063,-0.02827025,0.014337783,-0.035877805,0.0038370418,-0.04090871,-0.046333175,0.047847368,0.03690149,-0.024267843,0.04863238,0.0018400883,0.005775232,0.02646703,-0.0054255244,0.021461476,-0.02081216,-0.0029802632,-0.03411491,-0.015461015,-0.08007644,-0.010594525,-0.030614423,-0.02940995,0.05415196,0.0155150965,0.0063666347,0.0022342629,-0.026553987,-0.035058558,-0.056124948,0.043589666,0.025728988,0.07141681,0.007964141,-0.021250516,-0.018559135,0.02706989,-0.021303698,0.0050424538,0.06047876,-0.018805046,0.07878395,-0.057001512,0.017539619,-0.057037655,-0.039037023,-0.039978534,-0.023873813,-0.043982446,0.034944292,0.059705116,0.029035361,0.04382703,-0.021659236,-0.08069012,0.044269428,-0.062954016,0.056631666,-0.02578923,-0.028772289,0.099925995,0.053060044,0.010414955,-0.07239891,0.09190233,-0.043833993,0.011224176,-0.0080848755,-0.011856963,-0.02134586,0.019580826,-0.050954778,0.03812893,0.07441162,-0.04918492,-0.00055050844,-0.055702925,-0.025003603,-0.01109715,-0.05499052,-0.11996558,-0.009034371,0.018032108,0.010556358,0.04032875,0.06635095,-0.0057113757,0.08184753,-0.0571828,0.042608798,-0.008709429,-0.00701523,0.07552754,-0.0074548833,-0.08470789,-0.087850414,0.015550607,0.039887093,0.07286854,0.057421617,0.09592669,-0.032307446,0.060963314,-0.008259071,1.6574527e-33,0.109404705,0.031819534,-0.043127313,0.016397605,-0.058939964,0.04524772,-0.057420466,-0.011340523,0.033211708,-0.026776422,-0.05392785,-0.11622203,0.103470504,-0.013146155,0.000111451605,0.021959374,-0.10189757,-0.012925802,0.039157566,0.038130265,-0.023203421,-0.067059554,-0.06375131,-0.008979278,0.01210387,0.01758334,-0.027930237,0.015705211,0.08986431,0.00149627,0.0064641032,-0.064031266,-0.11747191,0.026942795,-0.0027549136,-0.017111575,-0.04851764,-0.028599659,-0.096702546,0.030431408,-0.009117771,0.07743724,-0.049879543,-0.019152706,0.104950644,-0.043379083,-0.01915435,0.12511417,0.052578278,0.024164455,-0.0077151,-0.052645,0.069545425,-0.03029888,-0.03831589,-0.039217055,0.003014528,0.04091172,0.07508766,0.04345776,-0.025264775,0.020860167,-0.026909256,0.076278634,-0.01629258,-0.0346389,-0.07572625,-0.022656681,-0.082892716,0.048558537,0.0073184967,0.014560682,0.09544543,-0.049657334,-0.06949886,-0.03621409,0.017349098,0.064299196,0.014597907,-0.0010911216,0.06060498,0.013696333,0.0021277796,-0.044282295,-0.010023096,0.03681792,0.015409299,-0.061366115,-0.013596487,-0.015142832,0.051173512,-0.05786125,-0.085996695,-0.07571845,0.019544056,-2.7014504e-33,0.017068319,-0.05148507,0.001253318,-0.04008553,0.04491953,0.065492906,0.011517836,-0.00439275,-0.011901401,-0.09580407,0.08365414,-0.05148022,0.07458592,-0.03992366,0.120214395,-0.06315143,-0.1248584,0.12088356,0.056640532,-0.015026222,0.034311786,-0.026939854,-0.013364172,0.040594462,0.048038747,0.0064078113,-0.08356237,-0.014434393,0.046874437,0.034431696,0.020128284,0.041506324,-0.10175656,0.028939614,0.08061056,0.09115598,-0.1100078,-0.008193188,0.04614512,0.053397655,-0.0416779,0.020137636,0.06228795,0.043435168,-0.020749632,0.093713306,-0.086812004,-0.0024520732,0.1015942,-0.0937399,-0.01464922,-0.030508507,-0.063247696,0.0007830874,0.07489969,0.07264092,0.013736582,0.026782839,0.020926801,-0.052437786,-0.03371841,-0.03864457,0.04162177,0.021490168,-0.04160753,0.04045772,-0.0056523834,0.0680261,-0.026446164,0.01644878,0.048985995,-0.052944597,0.005932061,0.030575015,-0.06955967,-0.08143472,0.005918883,0.020751346,-0.02381137,0.071568154,0.012991511,0.047422472,0.032460283,0.0120252,0.01709444,-0.076143235,-0.056032386,0.10873904,-0.018675795,-0.021045247,-0.0648904,-0.004704058,-0.07387784,-0.01752727,0.074012525,-4.5075772e-08,0.04452287,-0.036180004,0.08098657,-0.04887564,0.024624033,0.012876019,0.034766585,-0.00064515736,0.059110206,-0.009743048,0.028823506,0.04683915,-0.011950776,-0.016942032,0.032180768,-0.028929833,-0.047688313,-0.005771126,-0.018515771,0.0074926447,-0.09263907,-0.049357235,-0.04087175,-0.027227484,-0.05843334,-0.0017534998,0.016323123,0.031734213,0.06975789,-0.07931963,-0.035215054,0.037395146,0.019285526,-0.028268805,-0.08617438,0.03118295,-0.03128956,0.08564067,-0.063380525,0.03513644,-0.014690311,-0.09773698,-0.067687474,0.012104404,0.047705933,-0.059300724,0.042934984,0.003871653,-0.053276476,-0.021901716,-0.03256665,-0.06266984,-0.004026671,0.007326477,-0.052693296,0.0417099,-0.06928917,-0.014534227,0.010634011,-0.080707155,0.03194066,0.081216775,0.12977695,0.027025098 +1.13.11.53,"Requires Ni2+. If iron(II) is bound instead of Ni2+, the reaction catalysed by EC 1.13.11.54, acireductone dioxygenase [iron(II)-requiring], occurs instead [1]. The enzyme from the bacterium Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC strain 8724 is involved in the methionine salvage pathway.",384,1.0,-0.13078189,0.016303027,-0.058708988,0.09834402,0.05767662,0.011141569,-0.09977656,-0.0025397246,-0.0061303363,-0.065547936,-0.053884663,-0.08726131,-0.025989547,0.0013475823,-0.053143,0.01533705,-0.03771761,-0.014510539,-0.007248528,-0.0056382488,-0.03915412,0.03886547,-0.0039597666,-0.11466289,0.014894572,0.0025346836,0.0051075155,0.009667196,0.0082193045,-0.03685362,0.03293332,-0.019039894,0.05451405,-0.04060174,0.025746055,0.0810632,-0.028129075,-0.015395257,0.034014992,-0.023374313,-0.0027627943,0.012856522,0.030400114,0.0039725085,0.006873183,-0.018469479,0.046721682,-0.004881419,0.029483156,0.013443519,-0.08054318,0.009665794,-0.018967493,0.047011364,0.08343206,0.039315727,-0.04875319,-0.056353714,-0.017697055,0.0016460129,0.032893654,-0.05960514,-0.023039714,-0.015659295,0.045005083,-0.06168905,0.048624035,-0.10701255,0.042523682,-0.03453702,-0.0074008,-0.015895393,-0.04597376,-0.0058335066,-0.009564342,0.014965867,0.015697192,-0.057414133,0.07771049,-0.06647165,-0.019421047,0.0065227253,0.040452722,0.05244551,0.05134029,-0.035798095,-0.019058773,-0.059151437,0.04007591,0.060595952,-0.024500709,0.031808626,-0.0055413074,-0.007245087,0.0040427344,0.028416654,0.04093482,0.1365061,-0.09868055,0.04024964,-0.055872694,0.0829404,-0.09061097,-0.032457065,-0.055859078,-0.08847585,0.026458755,0.060193848,0.022946607,0.04907321,0.13384008,-0.060765576,0.058205675,-0.02514297,0.060765572,0.092685245,0.05411919,-0.081581585,-0.055233166,-0.0125473,0.038243573,-0.015391903,-0.01224651,0.009569548,-0.0739887,-0.017270705,-0.029955653,4.3749608e-33,0.056688763,0.052068222,-0.040821392,0.0027772,0.022609597,-0.034612328,-0.15462856,-0.03784634,-0.024972467,-0.045154236,-0.07397147,-0.024836728,0.0260267,-0.025971254,-0.07066649,-0.04062508,0.031085897,-0.039427396,0.073465884,0.025037635,0.043841153,-0.016583515,-0.01499465,0.03622437,0.0064486647,0.05768928,0.030348234,-0.017074684,0.03030242,0.009936435,0.035833005,-0.0659512,-0.08327372,0.016302695,-0.0022382657,0.0003161026,-0.06987943,0.006337443,-0.042360034,0.05949621,-0.028371327,0.08394148,-0.05893751,-0.049461175,0.10140725,-0.08275849,-0.03515875,0.14752454,-0.0004667047,0.09202863,-0.016147368,-0.013174161,0.13517606,-0.005625481,-0.09407965,0.06180943,0.018652854,0.011437375,0.11771205,0.07681373,0.016623685,0.017189404,0.018452527,0.12258991,0.033042487,0.02574094,-0.053743202,-0.0049332622,-0.007491312,0.10220344,-0.046899203,0.023371628,0.047352646,0.027314296,0.024331935,-0.05911215,-0.05355598,-0.008878823,0.07170982,0.03846385,0.043129105,0.02154322,0.023179881,-0.06170346,-0.039627437,-0.020332916,-0.08670422,-0.0018834784,0.0065094354,0.00815464,0.025921334,-0.026450362,-0.06726869,-0.038322117,0.06841588,-4.3361588e-33,0.076699175,-0.033726264,-0.021885987,-0.074333295,-0.05511722,0.09327462,-0.0203831,-0.113943584,0.03593287,0.024375178,0.124685146,-0.060629915,0.028598342,-0.06491215,0.062467705,-0.017573051,-0.05008141,0.09604868,0.026134368,0.022808462,0.054205272,0.037943076,-0.058055177,-0.03303908,0.05324121,0.031313803,-0.0711379,0.055776816,0.060387406,0.049026173,-0.043878675,0.02874094,-0.055802934,-0.034343164,-0.0013007892,0.050232287,-0.03798079,0.0071676834,-0.0068460526,0.031833667,0.05310414,0.012252224,-0.010978098,0.16522908,0.0642443,0.013594359,-0.09185648,0.0057400144,0.018500162,-0.119405046,0.055504978,-0.018815093,-0.07431918,-0.023949042,-0.008982779,0.07300748,0.016259369,0.06686577,0.025814824,-0.039389975,-0.04158921,-0.047010724,0.06765201,-0.008855882,0.0005207772,0.006743833,-0.017380798,0.08635607,0.024731848,0.010599499,-0.01925509,0.018404162,0.086686105,-0.049824703,-0.01752535,0.008896732,-0.01215671,0.09170824,-0.0022942936,0.014286932,0.0052367235,-3.490148e-05,0.022683702,-0.015487425,0.024669755,-0.059583277,0.04753851,0.025547208,-0.025728468,-0.0046145837,-0.08155171,-0.00908619,-0.033601206,0.01403841,-0.04349198,-4.3945626e-08,0.020647652,-0.0703547,0.0376555,-0.0297995,0.06536418,0.04875506,-0.015997874,-0.027697302,0.019793205,-0.018876348,0.012472125,0.08858417,0.041307185,-0.030491427,0.010796112,0.05057266,-0.0039473814,-0.03649153,-0.04657117,0.030664572,-0.050008867,-0.0067679435,-0.048107274,0.053912025,-0.008779396,-0.05263741,-0.02350827,-0.039561436,-0.05200854,-0.081863135,-0.027405413,0.040640783,-0.037184842,-0.013454689,-0.106223896,-0.03519664,-0.0078975065,-0.04071385,-0.028825792,-0.073041245,-0.037184127,0.037853096,-0.056207463,0.022376392,0.017045293,0.01551793,-0.023670364,-0.02306632,-0.07668336,-0.033116523,0.018248802,-0.027352158,0.064950824,-0.009461489,-0.082652844,0.109906234,0.02292316,-0.042246304,-0.018379578,0.00532284,0.042035207,0.009221153,0.10363925,-0.06318752 +1.13.11.54," Requires iron(II). If Ni2+ is bound instead of iron(II), the reaction catalysed by EC 1.13.11.53, acireductone dioxygenase (Ni2+-requiring), occurs instead. The enzyme from the bacterium Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC strain 8724 is involved in the methionine salvage pathway.",384,1.0,-0.13026418,0.014389175,-0.05182992,0.09937812,0.063068256,0.013470015,-0.09029606,-0.00045255804,-0.0049561197,-0.057259135,-0.03712338,-0.08870307,-0.030666633,0.007824307,-0.0481301,0.009069227,-0.04239595,-0.02454898,-0.016627923,-0.013487956,-0.027097244,0.040238958,-0.003199312,-0.110097334,0.021348529,-0.008189282,0.0014049696,0.008252854,0.024999231,-0.041158337,0.03748331,-0.015620352,0.058867496,-0.039572626,0.023584949,0.08518656,-0.033889677,-0.01454658,0.020392084,-0.02053864,-0.009553909,0.0006454492,0.031185288,0.011507566,0.009766741,-0.016847018,0.051890746,-0.00944966,0.019482415,-0.0052724425,-0.08593866,0.0014131655,-0.022897305,0.04932657,0.085787214,0.044311114,-0.049144626,-0.05085655,-0.017111333,-0.0003612281,0.027691888,-0.05159094,-0.029688505,-0.012650775,0.056363136,-0.06315201,0.05040704,-0.100383,0.040174898,-0.015486476,-0.001963929,-0.025486244,-0.045346897,0.006829293,-0.013919986,0.006802315,0.011854603,-0.047364056,0.06928769,-0.06607133,-0.018427232,0.011521902,0.026527956,0.06226651,0.055021573,-0.031188538,-0.019514684,-0.06878261,0.029670605,0.051086858,-0.019073289,0.025034064,-0.016105654,-0.0026166176,0.0033772876,0.022070436,0.04306668,0.12806985,-0.09021559,0.036861125,-0.055795614,0.07613588,-0.08307259,-0.020522514,-0.06637043,-0.08729458,0.022220537,0.054103274,0.024380602,0.061915033,0.13418943,-0.060745165,0.05384358,-0.022879384,0.053461965,0.085332125,0.057219286,-0.08607235,-0.04789612,-0.0061103874,0.03134676,-0.019028498,-0.0116338935,0.009201475,-0.08249971,-0.014214343,-0.025277833,3.9524436e-33,0.065192565,0.03926635,-0.045443345,0.0081986515,0.011816974,-0.031206045,-0.15272155,-0.03767898,-0.024572585,-0.060408365,-0.07127454,-0.025257733,0.025199378,-0.017581757,-0.06905978,-0.030565545,0.021647004,-0.03715757,0.07337934,0.03295944,0.034760527,-0.020930914,-0.01953358,0.03286602,0.012775397,0.055175386,0.034553662,-0.025822049,0.020211764,0.0088841915,0.031714987,-0.07080846,-0.07615578,0.017345829,-0.005830772,0.0075296103,-0.06617586,-0.001796758,-0.042578045,0.057142574,-0.020066598,0.0889226,-0.053187508,-0.043960296,0.10339735,-0.0762919,-0.03187688,0.14452474,-0.008091398,0.090445325,-0.008412796,-0.013776214,0.13651364,-0.005308168,-0.09267303,0.058093626,0.012642647,0.0010363967,0.105356775,0.07385783,0.011260781,0.012261047,0.013505708,0.13133919,0.036170278,0.02759781,-0.0655538,-0.007827196,-0.007767068,0.09408405,-0.05677366,0.018270744,0.042155925,0.031257525,0.015000691,-0.057097096,-0.05727327,-0.0032674752,0.06913688,0.03926963,0.038216203,0.016974676,0.020084502,-0.060004286,-0.043510634,-0.023002664,-0.07823715,-0.00015691863,0.012561808,0.0025424082,0.0396282,-0.04234739,-0.07692553,-0.045557514,0.07278157,-4.0356606e-33,0.07663781,-0.026498405,-0.027261248,-0.08107084,-0.032712627,0.09442139,-0.016376872,-0.1251226,0.035733502,0.015497128,0.11700935,-0.06992033,0.026823202,-0.055767745,0.059624698,-0.029560484,-0.0666409,0.10370736,0.014922109,0.012156495,0.058144614,0.04740016,-0.051226187,-0.04156136,0.049518548,0.04348959,-0.07755825,0.06442494,0.044904903,0.04913921,-0.037389163,0.024161253,-0.061902694,-0.03796337,0.0029920288,0.05497667,-0.041316457,0.02358458,-0.009247859,0.02129482,0.0588818,0.029300053,-0.00559837,0.1721971,0.0484508,0.016778538,-0.08445276,-0.010018389,0.025987709,-0.11907294,0.0609894,-0.025216406,-0.066982746,-0.016354661,-0.0017555564,0.07163163,0.010994653,0.07350531,0.019469792,-0.041285448,-0.038361263,-0.046170164,0.07054965,-0.022446996,-0.0028463034,-0.005907135,-0.009152351,0.085356295,0.039853625,0.0053789695,-0.019818569,0.020294763,0.09868285,-0.05745887,-0.020058297,0.019388303,-0.025366046,0.09117343,0.009976051,0.0021773563,-0.010508737,0.0030196065,0.014840661,0.00043498704,0.024454938,-0.042745378,0.037455857,0.021368934,-0.017262762,0.000285492,-0.06766105,-0.009066878,-0.03699816,0.025890827,-0.036215544,-4.2571536e-08,0.027243031,-0.08221069,0.032270912,-0.03195326,0.070291616,0.05207475,-0.008224343,-0.016572412,0.02150495,-0.025960663,0.018033328,0.10784539,0.034452364,-0.023185864,0.013794042,0.057829782,0.00019580175,-0.033012312,-0.06030497,0.012644259,-0.06301052,-0.015408806,-0.04469536,0.07320183,-0.0078662215,-0.0419847,-0.017125515,-0.022314204,-0.03246729,-0.07931331,-0.014585382,0.03669967,-0.03800021,-0.017961672,-0.110639036,-0.025413157,0.0028703809,-0.03477636,-0.03155362,-0.08349166,-0.035982765,0.040530622,-0.05802639,0.024249034,0.0216758,0.018467778,-0.036523312,-0.015283252,-0.08521142,-0.033122633,0.010163279,-0.042983096,0.06211278,-0.00094596035,-0.094151035,0.096060865,0.028116366,-0.037566416,-0.0140606025,-0.0039444254,0.039176866,0.012750879,0.12684675,-0.05884965 +1.13.11.55,"This enzyme, which is found in thermophilic microorganisms, contains one mononuclear none-heme iron centre per subunit. Elemental sulfur is both the electron donor and one of the two known acceptors, the other being oxygen. Thiosulfate is also observed as a product, but is likely formed non-enzymically by a reaction between sulfite and sulfur [1]. This enzyme differs from EC 1.13.11.18, persulfide dioxygenase and EC 1.12.98.4, sulfhydrogenase, in that both activities occur simultaneously.",384,0.99999994,-0.061461885,0.00040169185,-0.11574085,-0.013306848,0.09365236,-0.028307099,-0.034856167,0.044665053,0.06032183,-0.053795453,0.006443358,-0.059070796,-0.0534051,-0.019265985,-0.07040859,0.043311484,-0.04236544,-0.0034842528,-0.0010112554,-0.049213342,0.038639594,0.013848323,-0.023523215,-0.036566895,0.008070593,0.08737862,0.039702646,-0.0024283675,-0.07127112,-0.05208148,-0.02893645,-0.058414795,0.05027222,-0.010927316,0.00040573088,0.1136091,-0.054253582,-0.07013891,-0.054258876,-0.05498678,-0.018007444,0.008653133,-0.084252104,-0.035279166,-0.05437078,-0.025086038,0.05663412,0.024582041,0.023835462,-0.023240417,-0.034615856,-0.044084005,-0.016616236,0.06448507,-0.013385682,-0.019195795,-0.012424288,-0.011290494,-0.03400104,-0.05462495,-0.019176662,-0.0048335213,-0.005185891,-0.0069711497,0.025103627,-0.049716283,0.06914523,-0.070735425,-0.04685159,-0.1064995,-0.064801745,0.0066323048,-0.021598144,0.026435398,-0.020823851,0.0734006,0.04658526,-0.055721138,0.11176065,0.028563868,-0.0017221576,0.019835083,0.003616643,0.113629594,0.024130873,-0.008494595,0.016786644,0.016776606,-0.021823654,0.018580273,-0.02202795,0.04061103,-0.01171062,-0.0492854,-0.01549977,0.06936172,-0.01138568,0.1697389,0.050032154,-0.060024224,0.0050446396,0.055486236,-0.053262714,-0.05965016,-0.02970403,-0.0031421916,-0.0003656324,0.10258852,0.06456262,-0.013298352,0.0058719427,-0.05009372,0.053642496,0.0004360577,-0.0118859755,0.11800721,0.06715659,-0.068938,-0.07684804,0.025291802,0.014243219,0.02683968,0.073001996,0.049145672,0.018792316,0.0020820778,-0.13795516,1.2618405e-33,0.04988056,0.07571225,0.05932383,-0.062158786,-0.05408867,-0.012961616,-0.10940588,0.070914306,-0.031781692,0.024486525,-0.07605395,-0.042947326,0.051253147,-0.043120597,-0.016042445,-0.048452426,0.04169869,0.013614505,0.053242803,0.008266243,-0.006268862,0.074206956,-0.0057059904,-0.035743985,-0.006007292,0.028576566,0.070995346,-0.010134627,0.01230173,-0.022382388,0.034765504,-0.08328206,-0.045321662,-0.014181026,0.074610196,-0.025735067,-0.02835255,0.06781252,-0.047144502,-0.024814203,0.014006663,0.05107439,0.029889986,-0.07742748,0.07386372,-0.12326603,-0.10826466,0.062012453,0.055332694,0.047254268,-0.02250999,-0.0116640525,0.12393877,-0.056288287,-0.031448215,0.029735243,0.01913621,0.03700924,0.053566076,0.03475632,0.019803518,0.0748969,-0.07208488,0.046353046,0.0021329103,0.004191734,-0.0075129485,0.010806315,0.008579802,0.1208298,-0.047890943,0.019121153,0.01916717,0.014418048,-0.019817308,-0.049978804,-0.06801506,-0.019439543,0.08232741,0.010605706,-0.027579563,-0.043986514,-0.020338992,-0.02500226,-0.09936969,0.012074724,-0.0666875,0.02083276,0.0069125397,0.086874455,0.012351944,-0.098081805,-0.11745302,-0.0047952924,0.013709802,-3.1492875e-33,0.061620034,-0.02509162,0.0111691775,-0.09876897,-0.017675677,0.10070774,0.012262942,0.03903081,0.03758128,0.04888474,0.097076185,0.015476592,0.04184273,-0.10555385,0.038390845,0.09802663,-0.018642645,0.04363809,-0.020977085,0.007910252,-0.00084569043,0.081775196,-0.019666329,0.004905106,-0.014446123,-0.01694121,0.018074218,0.033754695,0.08920333,0.031081835,-0.0018146365,0.0010685647,-0.0098755425,-0.06756909,-0.018296465,0.0035197008,-0.017166376,0.024928667,0.07639848,0.021633599,0.0063828994,-0.047477584,0.06395961,0.10630132,0.040992048,0.05152006,-0.09355361,-0.00078313117,0.028327022,-0.035237785,-0.031881582,-0.01128995,-0.006627206,0.007629126,0.04934747,0.025974177,-0.038374357,0.040553182,-0.048683126,-0.03784858,0.0055717495,-0.08540215,0.023806052,0.009210876,-0.057124272,0.03882386,-0.10671695,-0.03205615,0.0080183,0.012335422,0.023868166,-0.007414418,-0.0523468,-0.06987789,-0.0065291836,-0.025966644,-0.0005947584,0.06842589,0.0152666755,0.03314301,0.032105476,0.058093924,0.006168302,-0.06883674,0.04125855,-0.09735543,0.037364442,0.08411939,-0.049113765,0.002744365,-0.047213126,0.029227965,-0.07467867,-0.00804672,-0.022755058,-4.130791e-08,-0.03781776,-0.093544096,0.067837976,0.010295172,-0.039393418,0.053729054,0.039252758,0.00878308,-0.010630859,0.0711213,0.01764037,0.12854369,-0.02216333,-0.05762496,0.021890147,-0.01290572,-0.015998883,-0.005178656,0.019049436,-0.010270838,-0.0034632725,-0.017657498,-0.044568475,0.008441739,0.0032374824,-0.0450537,-0.024761256,-0.09883261,-0.037163004,-0.039520938,-0.0073393467,0.06077069,-0.02802139,-0.07325157,-0.027678095,-0.0074868277,-0.02100402,0.014512131,-0.032054823,-0.03501354,0.055138472,0.018999042,-0.087625764,0.021916019,0.027965007,0.05241075,0.0058925804,0.013134977,-0.027963022,-0.010995595,0.06367216,-0.018745715,0.0044638086,-0.061746653,-0.08023007,0.06990754,0.069064744,-0.092268564,0.028264241,-0.011252962,0.13007265,-0.04999728,0.12526222,0.0049287556 +1.13.12.14,"Chlorophyll b is required for the assembly of stable light-harvesting complexes (LHCs) in the chloroplast of green algae, cyanobacteria and plants [2,3]. Contains a mononuclear iron centre [3]. The enzyme catalyses two successive hydroxylations at the 7-methyl group of chlorophyllide a. The second step yields the aldehyde hydrate, which loses H2O spontaneously to form chlorophyllide b [2]. Chlorophyll a and protochlorophyllide a are not substrates [2].",384,1.0,-0.10205551,0.030867234,-0.072664164,0.039912578,0.0660542,0.044605758,0.012583325,-0.042084716,0.018898945,-0.0121759875,0.014331447,-0.11357442,-0.015817111,0.022931922,0.020023499,0.124918,-0.105646625,0.011949012,-0.07771009,0.025334187,0.0273501,-0.029413413,-0.06689405,0.013654569,-0.048590347,0.006970791,-0.0630194,0.010852972,0.0146988155,-0.08206543,-0.0515057,0.04387929,0.00695369,-0.044862017,0.09905068,0.06002545,-0.0011420989,-0.15017872,0.014512741,-0.004333679,-0.030035766,-0.009470641,0.0025721397,0.004885655,-0.09296743,0.016484875,0.08564176,0.016000357,-0.050383072,-0.06281134,0.017253183,-0.025673602,-0.030458836,0.008649007,-0.013968098,0.07774428,-0.027055418,0.009080854,0.049163084,-0.036155824,0.05758233,-0.019345727,-0.03596061,0.007621388,-0.022730054,-0.00788731,-0.04988452,-0.06318028,0.021358466,-0.04765709,-0.08081634,-0.0769801,-0.03421562,0.04552094,0.04347946,-0.003255625,0.07740043,-0.056917347,-0.046400372,0.0313577,-0.0022598205,0.03451725,-0.019857945,0.08884508,0.036131736,-0.02155115,-0.006740463,0.022060202,0.0031556154,-0.009465074,-0.036282104,0.019085405,-0.015668888,-0.030539721,-0.086162575,0.14451264,0.037272844,-0.079727195,0.04308096,-0.04634248,0.0023935002,0.024437163,-0.010954473,-0.05756338,0.026303388,-0.019061973,-0.05006831,0.105982974,0.015457217,-0.03100216,0.034233354,0.020948034,0.025954736,0.0045451783,-0.021897752,0.09755775,0.041292258,-0.023672417,-0.033087224,0.008583826,0.014259329,-0.019380167,0.014154985,0.012820951,-0.03657473,0.026574694,-0.07997082,4.9595616e-33,0.06296021,-0.052855123,-0.035491392,-0.011227993,0.020125609,-0.10626218,-0.01617964,-0.039464474,-0.060667798,-0.077605784,-0.02753009,-0.059539862,-0.002540306,-0.024817826,-0.049940646,-0.00588811,0.021431971,0.017520573,-0.06173866,0.06856451,0.023120584,0.079407886,-0.016427036,0.03176274,0.025134495,0.08675582,0.04457325,-0.03046688,0.117361605,-0.017884025,0.045806784,-0.0009877897,-0.046286948,0.026776394,0.07542191,0.052664846,-0.054249126,-0.0114710815,-0.009072965,0.061226774,-0.047229923,0.08880161,-0.023850024,0.0075377836,0.08586217,-0.033911902,-0.053235922,0.023613848,0.016990868,0.048447818,-0.019614412,-0.022054357,-0.018605249,0.008333709,-0.06576381,0.02524192,0.034191247,0.002600438,-0.01593672,0.040875223,-0.030546274,0.048348088,-0.024852527,0.03278042,0.04113977,0.0062948363,-0.012601607,0.031589933,-0.014404424,0.010094742,-0.051864848,-0.05199315,0.0641485,-0.012768495,0.14413764,-0.047401495,0.0032845514,-0.05835332,0.0072185625,0.064710304,0.056871094,0.009237989,0.1419448,-0.12365933,-0.111173876,-0.069596015,-0.01822835,-0.02743696,0.013277256,-0.019683171,0.011857718,0.01704632,0.049011033,-0.07055308,-0.08634533,-6.0975015e-33,0.08606894,-0.11892191,0.04521724,-0.05364507,-0.04570419,0.007911359,-0.08521754,-0.15994988,-0.048522443,0.07848945,0.11561059,0.05656852,-0.106541574,0.026590114,0.020228898,-0.05802909,0.098798275,0.10173363,-0.022736065,0.027322695,-0.029337224,0.026608994,0.048279084,0.01770684,0.03298785,-0.048204497,-0.010500332,0.001262078,0.08973632,-0.006859332,-0.072961055,-0.022621732,-0.017653564,0.0076042223,0.0533325,-0.011908558,-0.088601865,-0.028329523,0.017069295,0.09695949,0.03018113,-0.08124628,-0.029324856,0.0006455255,0.016293963,-0.021402115,-0.11522827,0.02755809,0.0077448483,-0.007627285,0.010684671,0.014447082,-0.047809605,-0.017347638,0.009775317,0.065341726,0.092070565,0.027941408,0.032127194,-0.011805506,0.002125949,-0.063250534,0.03777436,0.014554335,0.023470942,0.12525745,0.022757353,0.098026544,0.00036231233,0.016480543,0.042907875,0.054618075,0.08311596,-0.010314319,-0.02871238,-0.050688628,-0.008368645,-0.023375759,-0.05836108,-0.038496576,-0.001389999,0.009270217,0.06126068,-0.050022278,0.020344358,-0.11950532,-0.009730035,0.023981959,-0.06617827,-0.02254339,0.014163739,-0.01838241,0.07975745,0.090773836,0.08039021,-4.4352063e-08,-0.032200016,-0.012970576,-0.06639316,-0.027473997,-0.013599858,0.037530474,-0.051656548,-0.032928757,0.05763135,0.028494,-0.024468996,0.028514612,0.07351441,0.010205968,0.009036556,0.025063865,0.016482612,-0.06989677,0.030269615,0.03569206,-0.08943033,-0.04516913,-0.09808906,0.014824181,-0.019569673,0.0041123745,0.04555716,0.038749818,0.045186177,-0.025076399,0.04825748,0.04420578,-0.03559544,0.02814479,0.015441926,0.013646184,-0.035880532,-0.039740216,-0.042695362,0.063621536,0.014262743,0.027067853,-0.05407194,0.04060649,0.040711123,0.011607365,-0.009963677,0.021109005,-0.021425966,0.059821192,0.042691175,-0.021655008,0.00959731,-0.051466763,-0.06592726,0.026743878,0.02379113,-0.064192764,-0.06091833,0.0054551195,0.040488675,0.0052133854,0.094444595,0.012349031 +1.14.13.101,"A flavoprotein. NADH cannot replace NADPH. While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates [1]. Senecionine N-oxide is used by insects as a chemical defense: senecionine N-oxide is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P-450 oxidase when absorbed by insectivores.",384,0.99999994,-0.036101963,-0.10172018,-0.04011963,-0.0103334775,0.074985884,0.10664435,0.01783877,0.1043526,0.04167202,0.0060421587,-0.024907293,0.033349488,-0.09843421,0.06982205,-0.037117347,0.12158097,0.040990375,-0.0014524014,0.0145277055,-0.0022292342,0.0129925795,0.022302516,0.061506942,-0.04700224,0.011236185,0.0074100685,-0.08132332,0.003798976,0.013392197,-0.044434883,0.0059624,0.013535399,-0.044430498,-0.02771958,-0.041023787,-0.0043748687,-0.09461224,0.022893226,-0.0052272794,0.025724843,0.00074696203,0.017170856,-0.108451,0.03637989,-0.019627994,-0.07201397,-0.024715615,0.07924365,0.055481683,0.012115333,-0.02342195,-0.0019408148,-0.013065737,0.06639092,0.0059338007,-0.06547808,-0.0222684,-0.007113034,-0.05813078,-0.023220317,0.04547269,-0.007618042,0.07188768,-0.035606004,0.028087173,-0.010913247,-0.01748789,-0.017256819,0.058729373,-0.04804884,-0.07233232,-0.051623087,0.043081723,0.0029058068,-0.039253738,0.13974172,-0.054089226,0.010088047,-0.009725846,-0.048432335,0.03434124,-0.012302053,-0.010640427,0.09606774,0.13210665,0.014881581,-0.057147898,0.0659822,0.010394118,0.021184146,0.03352834,0.028278366,0.0189149,0.053987924,-0.08214788,0.04927569,0.008847591,0.033565514,-0.068417065,-0.009843082,-0.0072359354,0.030412836,-0.10887814,-0.044194136,-0.08392308,0.029626543,-0.0012832771,-0.042164706,-0.027481282,-0.0066321166,-0.06328401,-0.02174314,-0.041018195,-0.01513259,-0.021596134,-7.0305e-05,-0.031242535,-0.036172252,-0.01229696,0.0052145883,-0.041233122,0.04345433,0.005676726,0.070766956,0.09310112,0.031719342,-0.058911543,4.8128353e-33,0.09578755,0.066255055,-0.04774222,0.009431357,0.033296794,-0.01268604,-0.079716004,0.033946678,-0.008565319,-0.05887872,0.0065595806,-0.029552499,0.034189835,-0.031243352,0.08883034,0.056290835,-0.033741556,-0.038544446,0.09718245,-0.06560607,-0.009213907,0.013476922,-0.05724696,0.08515282,-0.008413664,0.046424918,-0.12020869,0.06651768,-0.02942205,-0.017172134,0.044223472,-0.11735048,-0.04317057,0.022467375,0.0074962075,-0.008988211,-0.103940204,-0.045115143,-0.11328054,0.03435333,-0.058071353,0.033261657,0.019868923,0.039433166,0.06679193,-0.09426665,-0.107823744,0.06984542,0.06851181,0.020588709,0.03526598,-0.06280588,0.1341536,0.021712745,-0.037881613,0.04138271,-0.039606847,-0.043598324,0.0032934763,0.02433798,-0.016099647,-0.036416,-0.030702362,-0.0200588,-0.0026644128,0.013405445,-0.04734231,-0.061690576,0.01045055,0.014992374,0.012065667,0.02182136,0.053293135,0.12749705,0.006715941,-0.0052273446,-0.0021201994,0.038789034,0.011231766,0.021474764,0.06351651,-0.049667608,-0.0043978365,0.013708084,-0.019085633,0.0074093477,0.031610023,-0.07877974,0.054936852,0.019075692,0.031077703,-0.03438748,-0.07099621,-0.03575459,0.0011739472,-4.8612444e-33,0.06463316,-0.0065973527,-0.0016406124,-0.026932238,-0.035487726,0.046617076,0.010666026,-0.080774575,0.03794932,-0.058842976,0.004015859,0.008304673,0.06881746,-0.009865024,0.0029566274,-0.047255315,-0.04962165,0.06120447,0.07404101,-0.05356468,-0.037075557,0.08983012,-0.027692908,0.05447826,0.06323225,-0.04523158,-0.035432685,0.010605728,0.052322306,0.0453454,0.037666794,0.080630556,-0.015632622,-0.06875176,0.07993938,0.02737588,-0.06929663,-0.030025732,0.007403456,0.08187253,0.022468599,0.024693957,0.02760675,-0.030063873,0.06605275,0.053344123,-0.09197021,-0.0013967254,0.032143574,-0.022693913,0.07157153,0.012394771,-0.056728393,0.021531405,0.14458692,0.079529434,0.0073544355,0.024025198,0.07778096,-0.022432074,0.037148435,-0.056603763,-0.030400863,-0.0045393426,-0.0034959714,0.06125366,-0.018419415,0.085085034,0.04031894,-0.014224648,0.06412759,0.019713715,0.034687303,0.04368371,-0.07542497,-0.040382057,0.007438069,0.04503686,-0.036602445,-0.009910362,0.006872237,0.019952444,-0.0023719918,-0.07177981,-0.0052920696,0.07348121,0.0038203078,0.037564684,-0.017965423,-0.043290872,0.014521952,-0.031259272,-0.03377328,0.047574878,0.003637811,-5.1976937e-08,0.07877048,0.008851551,0.052196845,-0.046189614,0.010897656,-0.033627383,0.067088366,-0.09472609,-0.022071324,-0.0091176545,-0.006599063,0.038093995,-0.009296062,0.02912055,0.052667495,-0.010230185,-0.014080549,-0.0069224145,-0.04515092,-0.008752443,-0.1126758,0.063804805,-0.11143043,-0.010208789,0.0021925722,-0.04628288,0.048398554,-0.07087272,0.064949006,-0.014653283,0.021937907,0.012422014,0.0951467,-0.060413595,-0.079550646,-0.006566373,-0.0039208047,-0.03327235,-0.009282729,0.07890292,-0.073211454,-0.0466509,0.0034322077,-0.024255898,0.05169008,-0.020901198,0.03561294,-0.004661985,-0.07243108,0.010953274,0.0534555,0.019201891,-0.057048835,-0.081554614,-0.092029445,-0.0070542134,-0.00840082,-0.03716183,-0.040678844,-0.15762587,-0.033147097,-0.046386994,0.14860645,-0.011642247 +1.17.99.4,"Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95 (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 [dihydrouracil dehydrogenase (NAD+)] or EC 1.3.1.2 [dihydropyrimidine dehydrogenase (NADP+)], EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6 (beta-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH3 and CO2 [5].",384,0.99999994,-0.04103825,-0.02192638,-0.023846922,-0.05842798,0.09694369,0.05169917,-0.07045379,0.033703625,0.03936335,0.011302794,-0.024864167,-0.0025293883,-0.100233264,0.009998054,-0.029385677,0.008334389,-0.12583773,-0.00044325372,0.013429512,-0.058329243,0.06675905,0.035277583,-0.06340927,0.011367993,0.013099262,0.015612111,0.055311624,-0.015630685,-0.051348295,-0.0968847,0.02924236,-0.113442786,0.060556684,-0.069730565,-0.0019328299,0.12672943,-0.02338195,-0.078960694,0.06347856,0.06176582,0.01845455,0.020066885,-0.030862993,0.016648987,-0.03559709,0.009677507,-0.0056627183,0.042096373,-0.028289508,-0.021759717,-0.037968557,0.033813257,-0.044551473,0.039412037,0.044014882,-0.012337869,-0.0023020026,0.044591565,-0.056527372,-0.0029981676,0.04022654,-0.041318968,0.02168772,-0.065881476,-0.037848257,-0.03076016,0.034343183,-0.10423204,0.05055237,-0.033944402,-0.11437299,-0.07230651,0.00062346266,0.047866683,-0.046570852,0.020622129,0.0016598802,-0.029699195,-0.016289452,-0.031663768,0.023355208,-0.015478903,-0.030122066,0.0038194782,0.032183915,-0.04192823,-0.052454967,-0.060875043,0.03714807,0.020767134,0.036771193,-0.016034273,0.0052546053,0.021884939,-0.042256933,0.08231803,0.02582483,-0.00068117253,0.013563654,-0.04009071,-0.044002853,0.056943696,-0.08921853,-0.08190229,-0.056670245,0.044582628,0.017532857,0.089429095,-0.0019303821,0.018413562,-0.006870303,0.039125554,0.020449119,0.04922762,-0.033412907,0.046229925,0.011900711,-0.076776475,-0.019890266,-0.0007575784,0.009606723,0.009497578,0.0892865,0.0538582,-0.06105606,0.0023085678,-0.105296046,3.393192e-33,0.046661235,-0.00802053,-0.047709744,-0.014439736,0.027526712,0.022772014,-0.107666455,0.020704232,0.012595742,-0.08052834,-0.039727636,-0.05749909,0.037282523,-0.0007783948,-0.012916884,-0.021714436,-0.02611014,0.02012076,0.039845165,-0.0019008033,-0.0045485604,0.030254696,-0.03614406,0.017950036,0.09112622,0.038844913,0.002665082,-0.00016371124,0.04776719,-0.031200802,0.009922783,-0.13339524,-0.08662235,0.022938453,0.046550248,-0.0009274,-0.043796837,0.0058496576,0.015593379,0.06997696,0.013436526,0.037254352,-0.0027345421,-0.050618354,0.017435709,-0.02666568,-0.03369523,0.10104041,0.0057533113,0.01011366,-0.0038917079,-0.044312596,0.12203961,-0.012035016,-0.03900178,-0.019494286,-0.04028233,0.008497443,0.035688728,0.061891552,0.057003863,0.10508193,0.006851659,0.020646468,0.06477081,-0.04265817,-0.08482734,0.008859913,0.080520205,0.055917345,-0.08778794,0.013741516,0.06443729,-0.027215892,0.02431011,-0.07181676,-0.09410761,0.10257705,0.00602013,0.020854361,-0.030698374,0.027020253,-0.0032933366,0.005076897,0.00040169762,0.10593143,0.022317383,-0.07285879,0.02408656,0.040899497,0.05459486,-0.07027099,-0.010929877,-0.046794247,0.051002562,-3.365085e-33,0.1012246,-0.06879599,0.031112282,-0.024591174,-0.027847707,0.048383173,0.024247117,-0.0074465466,-0.011880786,-0.0375604,0.027164437,0.04964212,-0.020800877,-0.071219064,0.03202225,-0.042618174,0.007856261,0.07713823,-0.018818593,-0.048258394,0.009379454,0.06253012,-0.076239884,-0.0033439428,0.04738654,-0.02548873,-0.0013525885,0.06366826,0.08502708,-0.038635816,-0.042132232,0.08678554,-0.07951054,-0.052945185,-0.0070555154,0.041022893,-0.12268033,-0.022044921,-0.018092116,0.022502812,0.047845207,0.04740716,-0.02892506,0.020917682,0.065616414,0.078177884,-0.10634674,0.046404798,0.0067770453,-0.01699797,0.062111758,-0.03126595,-0.060719844,0.031607356,0.0856739,-0.034960706,0.03013783,0.064621545,0.04970428,0.024396725,-0.031121671,-0.057623822,0.02048723,0.021096544,9.0383895e-05,-0.0011647134,-0.028211117,0.09983694,0.02772438,0.091928996,0.08116179,0.004793303,0.058408413,-0.008741624,-0.040183287,-0.03754424,-0.06002899,0.04870904,0.012529562,0.014544455,0.037829094,-0.020246783,-0.034243703,-0.049636714,0.0456307,-0.047948807,-0.011687407,0.10412451,-0.044973083,0.028933145,-0.029522128,-0.12626149,-0.06781077,0.053539205,0.040252313,-4.8276345e-08,0.033078846,-0.02328814,0.011383418,0.002195398,0.035603806,0.041840725,0.034411915,0.06836311,0.06523002,-0.058979537,0.0150106,0.046244305,0.049592637,0.030718386,0.005578184,0.024311582,-0.010497827,0.047115356,0.02139326,0.08597671,-0.07914475,-0.013927442,-0.18157281,0.06961648,0.08313231,-0.079208694,0.057507854,0.002631025,0.02067847,-0.0467626,0.038561817,0.036118202,0.13572676,-0.04805747,-0.025642453,-0.029153273,-0.04369252,0.049865473,-0.02341817,0.050195694,-0.028796852,-0.042150337,-0.04839154,-0.002967124,0.0022484483,0.0048846593,-0.028997976,0.05649163,-0.057647724,-0.024791004,0.021421911,-0.012818873,0.036854353,-0.07748543,-0.114978,0.03450481,-0.010604062,-0.07700747,-0.038342163,-0.03212611,0.057638697,0.0069185523,0.15275408,0.00013473847 +2.3.1.177,"A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC 2.3.1.151, benzophenone synthase.",384,1.0,-0.06941105,-0.04529816,-0.047569208,0.03159987,0.08005629,0.055323057,-0.057230856,0.031039922,0.036478285,-0.085086405,0.014952246,-0.10893154,-0.07591072,0.045113422,-0.10370526,0.0025397164,-0.06695465,0.022352958,0.011038253,-0.007609933,0.00345315,0.032381933,0.033379268,0.06747229,0.030001698,-0.06500426,0.044880603,0.0058294116,-0.0011509449,-0.03350756,0.011995056,-0.035684053,-0.040898193,-0.0077148005,-0.051687945,0.04400413,-0.003634087,-0.05985255,0.06043949,-0.0013729273,0.055983048,-0.04421084,-0.012255054,-0.04999529,0.022762379,-0.02011306,-0.033523872,0.008768256,0.04237125,-0.053958718,-0.04717807,-0.050537452,-0.05061724,-0.0072948462,0.017059093,0.01636406,-0.08508169,-0.024408907,0.049787465,0.09884026,0.04607906,0.06638483,-0.040952906,-0.010270346,0.01419105,-0.010251795,-0.06012297,0.017873451,0.032658722,0.025495796,-0.057713285,-0.047696408,-0.049891025,0.00037323608,0.03867731,0.032217383,-0.07685056,0.041617647,0.04866061,-0.048887406,-0.028778234,0.02956925,0.0052315625,0.13587166,0.0016146138,0.01405875,0.05538057,0.01472208,-0.008304149,-0.012996558,0.044181544,0.015940398,0.03469889,0.013859465,0.007913257,0.06378339,0.027110394,0.061111793,0.044273913,0.023364257,-0.038689762,0.014614969,-0.008809988,-0.06100904,0.030751595,-0.029402127,-0.018811613,0.06480179,0.087667294,-0.046404,-0.066370256,-0.048106793,-0.08704978,-0.020432273,0.02168408,0.06762457,-0.04234005,-0.08528079,0.010433657,-0.007825567,0.025771186,-0.065848276,0.022573866,0.043774918,0.00045001763,-0.023467734,-0.05936392,2.8065345e-33,0.054680236,0.012789421,0.031255044,0.033125643,0.04880767,-0.018225892,-0.06717544,-0.003208705,-0.0021593096,-0.08856674,-0.097393006,-0.017898556,-0.05186654,0.10367277,0.0274902,-0.12287382,-0.042782847,-0.0023365042,0.0478269,0.028747164,0.041765325,-0.0036800327,-0.066055864,0.034420174,-0.08165619,0.06702938,-0.024146568,0.055225085,0.0129488055,0.013377608,-0.014015758,-0.03824947,-0.070776686,0.020809606,-0.04170216,0.010072696,-0.035850797,-0.06727365,0.0037333295,0.056408457,0.009501747,0.02971684,-0.008319811,-0.06766813,0.095593326,-0.010958326,-0.09714468,0.08432485,0.007230994,0.010879982,-0.0014175746,0.025625119,0.11483864,0.006178702,0.036394138,-0.020453682,-0.008092208,0.013574706,0.0097174,0.040884614,0.050005328,0.050349783,-0.06903457,0.099751845,-0.03767927,0.090899885,0.030576086,-0.03947894,0.012311823,-0.021195175,-0.020774119,-0.025850164,0.018548017,0.03531778,0.06471337,-0.03073054,-0.025888864,0.015221463,-0.034689073,-0.012191278,-0.04420185,0.024987714,0.007171711,0.015839564,-0.026463365,0.015680978,-0.0017861439,0.006851377,0.009719155,0.08091125,0.0532729,-0.09639775,0.0050379215,0.06355701,-0.02336476,-2.1396785e-33,0.08027175,-0.07152399,0.01625441,-0.11075643,-0.0546477,0.02778835,0.04922495,0.028144704,0.060364995,0.023175316,0.07910777,0.005328629,0.027890697,0.011575017,-0.04802533,0.022131538,0.025849922,0.023095528,0.039514735,0.00023464052,-0.027323708,0.06027093,0.018799568,-0.0021828352,0.036642212,0.022894867,0.054731466,0.09152292,-0.0712068,0.033168893,-0.068402424,-0.0474835,0.0004016649,-0.0022930426,-0.052001406,0.049983528,0.013959946,0.002739048,-0.06419737,-0.0032442969,0.027073454,-0.027735908,-0.03731899,0.0754253,0.05970592,0.076833956,-0.09128581,0.01974257,-0.0489919,-0.043694805,0.059671864,0.05481619,0.068930045,0.015281593,-0.050657008,0.048158433,0.095522165,0.022891851,0.033304263,-0.012443529,-0.04214343,-0.029783152,0.013311821,0.0024095364,0.028869553,0.03672915,-0.072904676,0.120857425,0.0022929416,0.00045977242,0.1416391,-0.012569068,0.03808336,0.04045833,-0.08626488,-0.0044348002,-0.025730215,-0.028930625,-0.014304777,0.035499234,0.02978885,-0.033630114,0.016222524,-0.059933316,-0.07894075,-0.059279222,0.06106988,0.12109483,-0.030558938,0.06955738,0.01820419,0.01195318,-0.091071054,0.05636136,0.05776712,-3.9819053e-08,0.018259615,-0.070949055,0.032436937,-0.08560623,0.041042536,0.034720257,-0.018210232,0.019194016,0.013694585,-0.004123008,-0.057729352,0.08241325,-0.030959995,0.031130258,-0.048533954,-0.005957676,0.047862064,0.07817551,-0.015046628,-0.05217273,-0.07383645,0.06453968,-0.019453233,-0.04479678,-0.027711751,-0.11759145,0.04095645,0.06844974,0.0016228245,-0.00017709138,0.0046526473,0.069666475,0.015035252,-0.021897085,-0.0842471,0.067664415,-0.08430022,-0.08913829,-0.05744773,-0.00417942,-0.044571206,-0.029882818,-0.023894366,-0.03986721,0.048231073,-0.0062790387,0.006845572,-0.038240932,0.034843743,-0.049295556,0.050795272,-0.018884873,0.052074224,-0.12850408,-0.09211424,0.011041294,-0.023475679,-0.07215262,-0.060967766,-0.044674184,-0.069036186,0.04863321,0.2381621,0.07593133 +2.3.1.178,"Requires Na+ or K+ for maximal activity [3]. Ornithine, lysine, aspartate, and alpha-, beta- and gamma-aminobutanoate cannot act as substrates [3]. However, acetyl-CoA can be replaced by propanoyl-CoA, although the reaction proceeds more slowly [3]. Forms part of the ectoine-biosynthesis pathway.",384,0.99999994,-0.066957615,-0.06771056,-0.031541914,-0.046882305,0.08662373,0.088219985,-0.05759736,-0.033103347,-0.00529992,0.066018745,0.0021615634,-0.08541786,-0.009419221,0.07675054,0.019295774,0.015923278,-0.029722918,0.015207291,0.010336134,0.005539795,0.028997742,0.008376711,-0.03448841,0.017927231,0.05622352,-0.006487172,0.013695073,-0.033636708,0.03719888,-0.107562035,-0.028995348,-0.037700657,0.049092285,-0.035153218,-0.011870889,0.034974717,-0.10974347,-0.049143855,-0.026981374,0.02512284,0.051338643,-0.05754096,-0.056869555,-0.026346356,0.008226175,-0.098012574,0.014254435,-0.084670596,0.06389319,0.018715782,-0.023067847,-0.028707447,-0.050670803,0.04535515,0.014641888,0.03581074,-0.107205905,-0.0061749225,0.007054035,0.035655614,0.031792596,0.021895023,-0.0051342626,-0.019550774,0.008592343,-0.007992133,-0.025194949,-0.028826091,0.017947806,0.049006876,-0.033127856,-0.105460875,0.0048569245,0.060514785,0.035107747,-0.0076969774,-0.0024070998,-0.01228148,0.007306264,-0.043344382,-0.039800767,-0.01667693,-0.03918852,0.069918126,0.06733957,0.030986635,-0.028916698,-0.025774233,0.0019952375,0.0072590653,0.04431278,0.014620791,0.087233074,-0.046397038,0.011020921,0.024954533,-0.00030350254,-0.011959172,0.03418229,0.010728651,0.009099722,0.13066727,-0.092389055,-0.012845871,-0.02846317,-0.03788199,0.0068296394,0.043590043,-0.033868745,0.051888596,-0.0022622976,-0.09034394,0.023682574,-0.0040168655,-0.061614078,0.092123196,-0.03430942,-0.08296466,-0.020521792,0.013459068,0.00125883,-0.001046317,0.037244547,0.12799321,0.004847435,0.060412377,-0.009267146,3.084959e-33,0.08085032,0.039278347,0.0441653,-0.045793198,0.01748672,0.005618346,-0.04140468,-0.016841445,0.101636186,-0.14219575,-0.04061618,-0.027551016,0.04971997,0.068472214,-0.016090551,-0.041849554,-0.010972845,-0.040753778,0.054274533,0.029895369,-0.04632559,-0.019755365,-0.068926446,0.055302892,0.0060589267,-0.020585138,-0.04194517,0.07582652,-0.0033189515,0.026921958,-0.009988287,-0.0563192,-0.0507849,0.043315146,-0.017453685,-0.04179635,-0.03412905,-0.03203654,0.023356473,0.07650093,-0.013667531,0.04585354,-0.050557572,0.033927526,0.029169623,-0.0034398858,0.01817927,0.14594592,-0.031459123,-0.0074131405,0.04270182,-0.039481424,0.05312805,-0.07925316,-0.050035134,0.09023268,-0.09558009,-0.019729799,0.06234128,0.03854681,-9.987072e-06,0.07032581,0.034506436,0.10569399,-0.0047946423,0.0824945,-0.09838629,-0.087260745,-0.026273904,-0.03765915,-0.030689914,0.006630344,0.083942115,0.068839654,0.061096244,-0.0244154,-0.07494437,0.033531368,0.0162392,0.0034087638,0.018349186,-0.021399895,-0.0014790138,0.003985533,0.023766255,-0.05233454,0.021553982,-0.07431501,0.061347418,0.05136373,0.024713457,-0.06149135,-0.014440931,-0.008044849,0.00662489,-3.0622583e-33,0.08475129,-0.10616284,-0.006798049,-0.040172968,-0.095021695,0.05960525,0.029756548,-0.09471899,0.055831276,0.033795416,0.086102255,0.03009836,0.00011934615,-0.09668625,-0.01084775,-0.02846463,-0.01841131,0.09572079,0.019763973,-0.0062286514,-0.00037956162,0.006613923,-0.015407219,0.032157693,0.092597105,0.030512793,-0.049933873,0.03754901,0.028522324,0.037258815,-0.03507052,0.03248746,-0.07098294,-0.058593255,-0.03000969,0.08137305,-0.009707251,0.059207506,-0.06569188,-0.025460085,-0.03824303,0.02851653,0.0331074,0.031214952,0.0528943,-0.01588322,0.00026377072,-0.027092451,-0.027603565,-0.11580117,0.03662435,-0.04023815,0.008253911,-0.024967363,0.023090376,0.11143814,0.0022598144,-0.0050317,0.093315125,-0.077594146,0.026239045,-0.029943105,0.010366857,-0.086596966,0.059312772,0.015430079,-0.043311708,0.100924134,0.010854525,-0.017015046,0.05762766,-0.020234156,0.1290395,0.038279694,-0.027099723,-0.023489865,-0.034484506,-0.063864686,-0.06658457,-0.035308007,-0.04445876,0.06307167,-0.050167155,-0.09917705,-0.07591356,0.036073115,0.012492982,0.092116505,0.003424516,0.044696677,-0.06727677,-0.05043274,-0.059903517,0.13225448,0.049195442,-4.37415e-08,0.09540043,-0.013297327,0.05270965,-0.023435108,0.027730126,0.0021308986,0.018947374,-0.021449832,0.06741077,-0.048704986,-0.04887143,0.10085872,0.08823424,0.03258586,0.025329854,0.035850734,0.08640179,0.058774717,-0.042034496,-0.01779021,-0.06943871,-0.009206539,-0.07275487,0.023773303,0.012821224,-0.099872954,0.04797553,0.073545404,-0.031335182,-0.034851026,-0.024583727,0.00027729466,0.014138992,-0.005549313,-0.005353977,-0.03857796,0.012546835,-0.0331952,-0.021337857,0.006756849,-0.082102686,-0.03466348,-0.033197694,0.030740405,0.067038864,-0.029047899,0.012250172,0.016867472,-0.031986594,-0.045756478,0.0076536043,-0.034898996,-0.039400212,-0.070649005,-0.010265805,-0.016944911,-0.024805726,-0.05189656,-0.007805943,-0.030641614,-0.03921783,-0.001430226,0.18285684,-0.008700674 +2.3.1.179," Involved in the dissociated (or type II) fatty acid biosynthesis system that occurs in plants and bacteria. While the substrate specificity of this enzyme is very similar to that of EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, it differs in that palmitoleoyl-[acyl-carrier protein] is not a good substrate of EC 2.3.1.41 but is an excellent substrate of this enzyme [1,2]. The fatty-acid composition of Escherichia coli changes as a function of growth temperature, with the proportion of unsaturated fatty acids increasing with lower growth temperature. This enzyme controls the temperature-dependent regulation of fatty-acid composition, with mutants lacking this acivity being deficient in the elongation of palmitoleate to cis-vaccenate at low temperatures [3,4]. ",384,0.99999994,-0.053518873,-0.11364945,-0.07861236,0.06741059,0.03173714,0.045449857,-0.115361325,0.015582476,0.065668486,-0.06585651,0.084323086,-0.09358024,-0.033229314,-0.020737197,0.037033662,-0.06062352,0.052097518,0.03364784,-0.045337364,-0.11195639,0.09131253,0.011314794,-0.057575103,-0.04721774,-0.040638715,-0.033774663,0.022924474,-0.034506947,-0.06264603,-0.09755572,-0.028343443,-0.056216177,0.06548188,-0.048940927,0.060400177,0.01253798,0.010085365,-0.112567626,0.0969717,-0.027846932,0.047207527,-0.0435465,0.032344088,0.0045412974,0.027301954,-0.04681801,0.00029835527,0.05003963,0.007813331,-0.1265406,-0.045378964,-0.058319658,0.02953516,-0.03934709,-0.03172935,0.041391257,0.0025239459,0.028071564,-0.03421239,0.019387143,0.060841072,0.035146613,-0.0066130543,-0.026063131,-0.043314826,-0.1247805,0.057561424,-0.078481816,0.046478365,0.0058412305,-0.11910425,-0.027038721,0.048161227,0.075519376,0.02156448,0.02030795,-0.026512938,-0.021949043,0.054563314,0.004748299,0.039475754,-0.048026748,-0.047027946,0.018836116,0.011758175,-0.07710729,0.0769479,0.02701602,0.017127812,0.09019498,0.045447078,-0.0030990879,0.005960469,-0.0014660452,-0.06938288,0.058521017,0.0059415135,-0.04806995,-0.007438829,-0.06516828,-0.0451692,0.042344816,-0.01402842,-0.0013553452,0.009172475,-0.0065638265,-0.046523206,0.059602164,-0.025428683,0.03546719,0.018398067,-0.014529622,0.0056363745,-0.0022521252,-0.0104478095,0.024629751,-0.004937661,-0.07954284,-0.02577103,0.046665538,-0.0015947162,-0.06489291,0.04623251,0.06064917,-0.07768838,-0.014710756,-0.056066547,5.983976e-34,0.041637547,-0.001662094,-0.029693382,-0.029930627,0.07171603,-0.104325436,-0.10005462,-0.016452536,-0.032797866,-0.044138532,0.03289716,-0.09556923,0.02550644,0.053399228,0.057837743,0.048202194,-0.035927963,0.05441756,0.052820314,0.028416838,-0.017419288,0.052376006,0.06332766,-0.01998206,0.063811146,0.031319976,-0.012451378,-0.042534277,0.0061075236,0.024554795,-0.0018295672,-0.09244024,-0.052251596,0.051523045,0.1063465,-0.000771872,0.018542608,-0.031629063,-0.008201208,0.046701048,0.050135944,0.04035782,0.050348036,-0.036356505,0.038676612,-0.02201286,-0.040330857,0.08043371,0.021958148,0.026262507,0.04041535,-0.021011328,0.097170144,0.0143935215,0.013415274,-0.003277368,-0.057536855,0.013839706,0.0061013647,-0.047523133,-0.05382165,0.07479528,-0.07564514,0.0085949,-0.06290405,0.033190478,-0.114222035,-0.04605235,0.016917054,0.11998353,0.03501771,-0.025486832,0.05071973,0.042779464,0.03553398,-0.032788455,-0.084675975,0.092172705,-0.02433478,0.03473985,0.029230008,0.04835301,0.011101348,-0.052368432,-0.06741551,-0.044994205,-0.061735548,0.058211036,0.09734892,0.05347272,0.028669603,-0.053186998,0.0049596825,0.13623433,0.0032055755,-2.1908122e-33,0.105751365,-0.06767214,0.05857589,-0.071642876,-0.07989845,0.041629124,-0.061877143,0.026645228,0.014013698,-0.07420037,0.022377558,0.035685234,0.040661737,-0.0360884,-0.058809064,-0.021574505,-0.047129095,0.04421182,-0.031012727,-0.051345497,-0.0065698763,-0.019595455,0.04775535,0.09724509,0.013231462,-0.0044945893,-0.046312597,0.08812723,-0.027262975,0.03502323,0.04122676,-0.013343129,-0.030004578,-0.029989913,-0.07146357,-0.001033972,-0.074802265,0.02327074,0.03480415,0.08599578,0.016503433,0.039689686,0.041386858,-0.04121635,0.06356825,0.01863022,0.06054078,-0.051921826,0.088562824,-0.103665985,0.033454098,-0.08408192,-0.02368449,0.02846177,-0.0019074595,0.06097448,-0.019416276,0.07929271,0.039579522,-0.03985257,-0.04563406,-0.11013298,0.043503996,-0.01440698,0.028963534,0.0039654383,-0.0070974566,0.05259708,0.04829073,0.07035805,0.046886846,0.021405606,0.03579029,0.01878344,0.00591835,-0.036109187,-0.07372238,-0.019815331,-0.028768199,-0.0006522504,-0.055905104,0.033451356,-0.069612026,-0.06285093,-0.004345832,0.006282961,0.028988885,0.0540376,0.013418264,0.032069035,-0.045545265,-0.036129184,-0.051236622,0.042805765,0.05218801,-4.6190046e-08,0.038930535,-0.0446711,0.009365946,0.017075516,-0.02121026,0.04992887,0.0067169634,-0.034594547,0.120138474,-0.009595016,-0.071383,0.101609804,0.044752683,0.05154072,-0.018162142,0.01314669,-0.012707616,-0.009354099,0.052753236,-0.038455147,-0.03717602,-0.06927146,-0.015476024,0.0022222453,0.029932953,-0.060276132,-0.00626859,0.02764642,-0.011370468,0.010176301,-0.054603532,0.03585865,0.05587624,0.0014113734,0.012778184,-0.043143734,-0.0031555605,-0.03197596,-0.04267077,0.10219477,0.0890943,0.035022393,-0.083232425,0.022883613,0.056146704,-0.0006413448,0.047622517,0.06840643,-0.057877604,-0.04455978,0.076906286,-0.018350916,-0.05381633,-0.041043613,-0.08502529,-0.01013087,-0.02549723,-0.039864764,0.026654817,0.028915117,0.03462677,-0.027120834,0.08651331,-5.8930567e-05 +2.3.1.180,"The enzyme is responsible for initiating straight-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, and EC 2.3.1.179, beta-ketoacyl-[acyl-carrier-protein] synthase II, this enzyme specifically uses short-chain acyl-CoA thioesters (preferably acetyl-CoA) rather than acyl-[acp] as its substrate [1]. The enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent [1]. The enzymes from some organisms (e.g. the Gram-positive bacterium Streptococcus pneumoniae) can accept branched-chain acyl-CoAs in addition to acetyl-CoA [5] (cf. EC 2.3.1.300, branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase).",384,1.0,-0.09796199,-0.06370415,-0.07020808,0.04651316,0.05407572,0.09321352,-0.17187595,0.02483745,0.06538307,-0.036728133,0.06361667,-0.096044175,-0.036429785,-0.0059062107,-0.00693855,-0.024379736,-0.029772596,0.023924405,0.016730784,-0.09267442,0.020014837,0.02888941,-0.06948065,0.0025369069,0.008203731,-0.04900861,0.010561024,-0.047772657,-0.03820632,-0.13283657,-0.020881902,-0.085675485,0.036007747,-0.0066458383,0.003379362,0.04778308,-0.033282377,-0.09724885,0.11420965,-0.002765687,0.05977654,-0.04595095,-0.01845585,-0.0022073162,-0.011635931,-0.06273055,0.002655993,0.06112632,0.01110608,-0.062569536,-0.02617107,-0.02930231,-0.013822568,0.023665445,-0.04618104,0.017117847,-0.015018296,-0.0064402367,-0.008483864,0.031712074,0.014922384,-0.026466116,-0.014253496,0.005583261,-0.07828816,-0.05167682,0.009893446,-0.0456847,0.06431643,0.0034553413,-0.07938341,-0.10688606,-0.009768773,0.07567673,0.048952114,0.02675535,-0.03129746,-0.019179836,0.03856898,-0.019290457,0.0009784532,0.008906319,-0.030743934,0.0016813086,0.047241244,-0.053360112,0.016397575,0.027083524,-0.014017212,0.028208097,0.06975975,-0.056470897,0.025828142,-0.008132442,-0.042608082,0.0579615,0.04590113,-0.008291371,0.020573895,-0.050521396,0.009056769,0.083476976,0.0026022957,-0.052087866,-0.0043241233,-0.009379673,-0.042360045,0.06088531,0.020401828,-0.0063279206,-0.021111116,-0.043750726,-0.012865063,-0.0055108345,0.008774583,0.052723967,-0.0109509155,-0.09322854,0.0124087,0.040893275,-0.01699934,-0.07210252,0.042938713,0.076584235,0.0047341892,0.0013317632,-0.14016517,5.6869696e-34,0.004687838,0.06383044,0.027923511,-0.041763574,0.072550505,-0.08914161,-0.11204839,0.042054195,-0.014514359,-0.0023330604,0.0008414345,-0.07329937,0.029828638,0.030255137,0.057321206,-0.025751079,-0.0034420737,0.009261361,0.056227177,0.020381588,-0.06032914,0.015353595,0.012900543,0.0010118101,0.07133954,0.0048194192,0.0070182513,0.061164185,0.057128005,0.026270254,-0.043826338,-0.052132037,-0.021981515,0.026171532,0.057918295,-0.02514326,-0.02224599,-0.034537643,-0.016672263,0.07477995,0.072974704,0.04559173,0.00039856884,-0.0028693173,0.02412952,-0.0088949315,-0.027994975,0.07085754,0.03664038,0.0724768,0.08519519,-0.015683623,0.098640196,-0.0049051913,-0.009518324,0.062926166,-0.095058836,0.01901753,0.035037175,-0.0147476625,0.0014819859,0.078984395,-0.053363595,-0.001241241,-0.08194985,0.036307875,-0.103767954,-0.007956236,-0.05258122,0.05795849,-0.00030301744,0.010107672,0.034747582,0.023313282,0.099351905,-0.008445765,-0.0837211,0.04481806,0.05949436,-0.0072315848,-0.024667174,0.04456815,0.04926431,-0.018644877,-0.03416294,-0.041802824,-0.0337032,0.05092489,0.057958826,0.029303806,0.032120027,-0.021230401,0.022204204,0.117789276,0.035896953,-1.9567218e-33,0.12172955,-0.11543402,0.045353502,-0.14479108,-0.04569082,0.0330234,-0.012402526,-0.0439451,0.032465678,-0.04704101,0.09937691,0.05129415,0.027269589,-0.012781253,0.035477806,-0.029265499,-0.010658703,0.025680566,-0.026752884,0.0034248005,0.040257968,-0.054351766,0.0075533865,0.040758017,0.038024623,0.048425656,-0.047104973,0.101921685,0.07122606,0.028947046,0.016178718,0.005892546,-0.02385134,-0.041989706,-0.063785605,0.0137466,-0.07555517,0.066044174,0.01659374,0.052108902,0.04163798,0.0058882884,0.0076409588,-0.0080042975,0.07449841,0.016168969,0.05153613,-0.059393603,0.018336685,-0.14764047,0.0012953308,-0.013034804,-0.039900042,0.06293863,-0.019372547,0.08793145,-0.029179161,0.07086407,0.07312328,-0.12348988,-0.076648735,-0.07729466,0.028806804,-0.025690231,0.06294035,-0.010342222,-0.051181726,0.0110505,0.024494596,0.04722742,0.015816996,0.056015894,-0.008455526,0.045900635,0.0007663716,-0.053388905,-0.03883129,-0.05174333,-0.037010685,-0.028571658,-0.030607192,-0.0109354155,-0.067719884,-0.042710625,-0.09324351,-0.044175275,0.042297557,0.05981711,0.0028344896,0.04213499,-0.013646251,0.02352865,-0.015189102,0.09108296,0.055309862,-4.7550884e-08,0.02378304,-0.04686924,0.03485045,-0.025253218,0.03165193,0.0102014085,-0.0029323995,-0.044234484,0.051709563,-0.056048565,-0.10988961,0.088601165,0.0655759,0.033301033,-0.018016433,0.0033163435,-0.047012307,0.020230304,0.06931712,-0.009102535,-0.072380126,-0.033131186,-0.008980011,0.054885253,0.002126759,-0.044620126,0.04011739,-0.0012683966,-0.026850676,0.025023356,-0.0413999,0.05463738,-0.006839143,-0.0132875545,0.018926715,-0.052286003,-0.0046768473,-0.06610326,-0.016419305,0.09305713,0.104764245,0.026090749,-0.052700836,0.021419354,0.08023272,-0.0069164718,0.06159648,0.041568846,-0.015402661,-0.045493376,0.016260305,-0.00029953863,-0.058668926,-0.051814836,-0.048486404,-0.038230035,-0.020275386,-0.09174879,-0.04626995,-0.008723934,0.030123375,-0.015908886,0.19847596,-0.029218536 +2.3.1.300,"The enzyme is responsible for initiating branched-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system (FAS-II) in some bacteria, using molecules derived from degradation of the branched-chain amino acids L-leucine, L-valine, and L-isoleucine to form the starting molecules for elongation by the FAS-II system. In some organisms the enzyme is also able to use acetyl-CoA, leading to production of a mix of branched-chain and straight-chain fatty acids [3] (cf. EC 2.3.1.180, beta-ketoacyl-[acyl-carrier-protein] synthase III).",384,1.0,-0.05468628,-0.09431135,-0.06364975,0.0032194324,0.040261865,0.05419581,-0.15441541,0.03144592,0.050159868,-0.063351974,0.05521919,-0.04422383,-0.018457914,-0.024384364,-0.027144684,-0.024274688,-0.09835789,0.00933768,0.0031794112,-0.08412041,0.08507432,0.02467707,-0.09503247,-0.0016638867,0.0220956,-0.05810124,0.04967219,-0.048175156,-0.026239187,-0.11090265,0.029775629,-0.09573727,0.07176284,-0.061917197,0.013497441,0.049184576,0.01831251,-0.07757296,0.13473539,0.016501373,0.04864225,-0.045458935,0.015786443,-0.022741558,0.02125752,-0.041102897,-0.029300194,0.026465865,-0.0069501493,-0.017988402,-0.040921763,-0.07155625,-0.016693084,0.027164562,0.025380371,0.03643202,-0.046409205,-0.012634266,-0.0144705875,0.02753403,0.03413698,-0.006948639,-0.007996465,-0.0053423485,-0.078827575,-0.0710589,0.01986544,-0.08192228,0.055920027,0.00075330236,-0.07362436,-0.0793419,-0.02467333,0.03899284,0.045980334,0.018989744,-0.07407906,-0.018127227,0.01057351,-0.030753022,0.006298362,-0.052549716,-0.034403514,0.03327427,0.0016356925,-0.06098813,0.030610437,0.006068938,-0.004144116,0.049258392,0.0133028375,-0.056847397,0.039203636,-0.017387267,-0.049298152,0.045967244,0.036874827,-0.026519243,0.022272844,-0.06259161,-0.006812255,0.03143983,-0.005764342,-0.051621653,-0.04229539,-0.03350518,-0.042596113,0.10865553,-0.030548787,0.0022739242,0.029188232,-0.015990268,0.031354792,0.015810644,-0.02033925,0.048434246,0.02899166,-0.10560966,0.0012463822,0.04218283,-0.025331343,-0.018755922,0.048444033,0.053961173,-0.027839493,-0.012224561,-0.08101246,-1.3814312e-33,0.011836583,0.006224302,-0.0008484433,-0.00020589825,0.057248406,-0.0689968,-0.09721791,-0.024981612,0.0141653195,-0.023407802,0.0057843183,-0.06574856,-0.00085689087,0.044391826,0.046931613,-0.017591313,0.044263106,0.017669277,0.062623724,0.018594977,-0.03912041,0.05347258,0.045917436,-0.04136712,0.07357273,0.016770007,-0.02073777,0.02488043,0.047609743,0.036644235,-0.006396107,-0.08941658,-0.043937515,0.017920295,0.07187926,0.011406841,0.0057051415,-0.045995228,-0.009895943,0.068329096,0.097091116,0.023149146,0.012205757,-0.013708147,0.0075941994,0.049935635,-0.020089084,0.073463544,0.037995767,0.036149707,0.06362344,-0.014418991,0.080591746,0.006784324,-0.029657295,0.04614263,-0.11500376,-0.011133954,0.020496918,0.010109451,0.0039145,0.08906722,-0.045221265,0.05041461,-0.046053022,-0.016632725,-0.07952318,-0.0109201055,-0.032817177,0.07682785,0.007865216,-0.03405735,0.05407566,0.044895083,0.065556996,-0.010300152,-0.11819369,0.012662192,0.00831168,0.009796237,-0.02227968,0.042588428,-0.0027752258,-0.007412037,-0.008821112,-0.030480511,-0.040557377,0.015675081,0.053076014,0.055117417,-0.039924722,-0.052050482,0.006853906,0.12681505,0.030850485,-1.796886e-33,0.10085376,-0.12270577,0.07761828,-0.10906459,-0.033831317,0.03997587,-0.02319368,-0.0070270374,0.03284715,-0.01492664,0.045234665,0.04828539,0.000771537,-0.02347037,-0.008308553,-0.032846823,-0.0016533921,0.0013558586,-0.012289813,-0.04823439,0.051909875,-0.03778416,0.019205064,0.077072375,0.038715854,0.05221765,-0.04733779,0.105623975,0.030447662,0.06625622,0.032551378,-0.008356188,0.013468609,-0.06833416,-0.073563695,0.034419723,-0.065228224,0.040230304,0.012684053,0.02672628,0.016940918,0.018358877,0.0042447303,-0.02224168,0.076227486,-0.008097362,0.053886145,-0.034450583,0.04765388,-0.1758225,0.007119483,-0.037044007,0.008628192,0.014902402,0.0061369217,0.072675794,-0.00847707,0.11524254,0.074553825,-0.10892193,-0.089975335,-0.13242045,0.01802177,-0.0425658,0.04136097,0.022519106,-0.033711415,0.0046925014,0.012752545,0.060177073,0.018505218,0.08312656,0.0075955433,0.09331786,0.00040175897,-0.04260687,-0.094273984,-0.074786484,-0.011926327,-0.035192903,-0.041716944,-0.010164107,-0.05998795,-0.042025536,-0.07623532,-0.08737789,0.06103091,0.093594275,-0.011329666,0.01961424,-0.021337593,0.005923761,-0.06540841,0.07047837,0.031263523,-4.272041e-08,0.034796137,-0.03732487,0.035009574,0.007406921,-0.02908354,0.013690449,0.011401494,-0.005152223,0.06859128,-0.10088092,-0.13407566,0.10538011,0.06304718,0.049577564,0.0023102446,0.02238716,-0.04010993,0.015864499,0.04582789,-0.018885119,-0.06796407,-0.03346903,-0.013346246,0.036995403,0.0027062432,-0.07063732,0.021581339,0.047429536,-0.017576577,0.031470183,0.017036991,0.06386379,0.011247359,0.012570523,-0.00036690544,-0.040104683,-0.041769683,-0.07372923,-0.008413967,0.09611724,0.065014325,0.029766114,-0.032202166,0.010830795,0.05676427,0.014684663,0.023987263,0.08935204,-0.028248023,-0.04752122,0.022484004,-0.011787768,-0.053447466,-0.018053032,-0.03703629,-0.058194544,-0.0300098,-0.09431321,-0.023296418,-0.0023296948,0.016278196,0.019183632,0.1835912,-0.00946729 +2.3.1.181,"This is the first committed step in the biosynthesis of lipoyl cofactor. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [2,3]. Lipoyl-ACP can also act as a substrate [4] although octanoyl-ACP is likely to be the true substrate [6]. The other enzyme involved in the biosynthesis of lipoyl cofactor is EC 2.8.1.8, lipoyl synthase. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues). 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The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.",384,0.99999994,-0.0393039,-0.07515332,-0.0859617,-0.004032688,0.024666004,-0.0008593583,-0.045339376,0.01425177,0.0400927,0.0020070656,-0.0031048544,0.13486227,-0.013016249,0.00017502463,-0.104765244,-0.055304367,0.029714707,-0.03840438,-0.0147323,-0.023608496,0.05503847,-0.020754399,-0.021580938,-0.037851572,0.009429638,-0.051143486,-0.013407598,-0.038732957,-0.03580539,-0.05990895,-0.020608554,-0.09127772,0.020764088,0.0037493226,-0.008918754,0.049890056,-0.010249749,0.051105794,0.02211148,-0.025017243,-0.038222652,-0.010833579,0.0172655,-0.0163899,-0.015299882,-0.051744517,-0.06573844,-0.019047385,0.027376663,0.06388833,0.051996067,-0.018478328,-0.024811588,0.06983155,0.06922113,0.051807754,-0.09214556,-0.029127106,0.039772708,0.08802622,0.040385835,0.0447265,0.010284374,-0.026409123,-0.04143311,-0.048979357,0.08913281,-0.029229933,-0.049884375,0.012840594,-0.013990834,-0.00030951924,-0.018280355,0.02039928,0.06778243,0.04149613,-0.0706051,0.026018932,0.035428796,-0.0014993682,0.056099657,0.053586677,0.040294226,0.07328568,-0.058906954,0.017179538,-0.019690773,0.067160614,0.030306758,-0.036986448,-0.0014292537,-0.058464736,-0.028982498,-0.032136735,0.011424464,-0.050388806,0.034196544,-0.025509441,-0.013999683,-0.017404765,-0.008242367,-0.024022663,0.047146965,-0.06434123,-0.08051542,0.07422189,0.012117176,0.038020767,0.08312042,0.0029197556,-0.04522789,0.09831556,-0.016818311,-0.011485403,-0.11178244,-0.011886968,-0.0029437786,-0.07129711,-0.0758702,-0.021836493,0.04990136,0.03954637,0.079096116,0.032300536,0.03539225,0.05927893,0.051503252,2.1849435e-33,0.06977745,0.049880303,0.08392306,-0.021779574,0.017032802,-0.0044687623,-0.0304073,0.009780118,0.018722847,0.011355178,-0.03940035,-0.014945395,-0.033763386,0.11431582,-0.011369938,0.18193369,0.018262532,-0.059343923,0.035884757,-0.046223763,-0.0060310974,0.058786493,-0.034308117,-0.020154031,0.090317905,0.042393632,-0.07194294,0.06789639,0.056970015,-0.0030451636,5.1694653e-05,-0.06780255,-0.058041222,0.055429094,0.05657672,0.06896361,-0.050189022,-0.04618305,0.101098455,-0.001991976,0.080693685,0.009677702,0.012910741,0.020164143,-0.03363087,0.046625316,-0.008644773,-0.057246137,-0.09112308,0.07625358,0.018160444,-0.037127256,-0.001400384,0.016772151,-0.07378042,0.06866178,-0.035118867,-0.053368703,0.008050791,0.11411531,0.01875081,0.0023925053,0.039731752,-0.06496876,0.01885395,-0.023677655,-0.10903478,0.01652773,-0.055857915,0.0030017772,-0.009772144,-0.09383296,0.03135511,0.078572474,0.025362154,-0.08340154,0.041492525,0.05188536,0.009598741,-0.034466576,0.028160742,0.034948967,-0.021053722,-0.021157026,-0.05798065,0.067349546,-0.02243287,-0.14767858,-0.0074486313,0.05408359,-0.07394636,-0.02891235,-0.05399765,0.030467773,-0.075845316,-4.832201e-33,0.09800552,-0.1068804,0.097012095,-0.010574762,-0.0033058464,0.026438221,0.025796974,-0.028466597,-0.008327396,-0.014315989,0.043665703,-0.009779872,-0.03200485,-0.007801662,0.0052511306,0.00062386587,-0.058356773,0.09990425,-0.022916924,0.018808424,-0.060627427,0.023301387,-0.0037517603,-0.04460285,0.057198893,-0.020355903,0.022715416,0.011531876,0.041640162,0.06819365,0.015133074,0.02467516,-0.06545618,-0.05935272,-0.0008201758,0.0041042017,-0.034055665,-0.05770559,-0.048710965,-0.014793413,0.012355923,0.08039949,0.008918051,-0.031985298,0.09026053,0.07402518,-0.057730883,-0.025844535,-0.02795421,-0.01750179,0.034508202,-0.0068576727,-0.015911974,0.052511998,0.06516305,0.08640033,0.09534431,0.023369923,0.019983612,-0.029851338,-0.049057927,-0.0038667007,-0.037916273,-0.054792076,0.06745933,0.013261767,0.029680686,0.040894065,0.021307854,0.026163517,-0.036827754,-0.08607926,0.045936234,0.026631253,-0.01658868,0.0253672,-0.10157771,-0.062009923,-0.034683,-0.046999708,0.019349081,-0.008778508,0.002337649,-0.04353478,0.017648255,-0.019144425,0.056072164,0.14248039,-0.006226941,0.058213517,-0.042878482,-0.011085976,-0.04518864,0.019482842,0.042902213,-4.2271047e-08,0.0827044,-0.016063776,-0.0246938,-0.09377918,-0.06690218,-0.0027328257,0.005147898,0.008125274,-0.01424853,-0.014603538,-0.05613335,0.08209614,-0.027297486,-0.016439574,-0.12828232,0.08715006,-0.051233124,-0.0045669116,0.014241749,0.07893116,-0.14012946,0.04757077,-0.09396312,0.035445746,-0.0076459176,-0.07369901,0.07113219,0.07462359,-0.017334044,-0.0067775105,0.009032326,0.04370891,-0.061210234,-0.07495288,9.2744776e-05,-0.033459976,-0.023952091,-0.011803279,0.0628386,-0.011777276,0.0045484276,0.049242545,-0.054597992,0.017519241,0.011212964,-0.038981844,-0.0074784206,0.017113442,-0.056738,0.08578924,-0.008497655,-0.003104825,-0.06062166,-0.118374586,-0.092519134,-0.053365458,-0.020457666,-0.03811751,0.022374496,-0.073420554,-0.046752688,-0.054378137,0.0944441,0.023830418 +2.6.1.81,"A pyridoxal-phosphate protein. Also acts on N2-acetyl-L-ornithine and L-ornithine, but more slowly [3]. In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, acetylornithine transaminase (EC 2.6.1.11) and ornithine aminotransferase (EC 2.6.1.13) activities are catalysed by the same enzyme, but this is not the case in all species [5]. This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6]. 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+2.6.99.2,"In Escherichia coli, the cofactor pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3].",384,1.0,-0.05274381,-0.059476536,-0.037872,-0.080957785,0.043329287,0.0066244747,-0.100741506,0.024882494,0.013405932,0.03684261,0.028997464,0.008296186,-0.063200854,0.044161938,-0.008002622,-0.031034555,-0.049294528,0.029450024,0.0319068,-0.045993637,0.12082531,0.033412904,-0.030264966,-0.005814353,0.032688558,0.03319784,0.06250481,0.021971531,-0.07289947,-0.08466238,-0.059835374,-0.05360001,0.008774239,-0.103851154,0.04029814,0.14439937,-0.046802543,-0.07609339,0.1020479,-0.0017557463,0.036003157,-0.030268982,-0.03870532,-0.006164119,-0.05462835,-0.049028292,0.007494747,0.030180905,0.004716218,-0.07280322,-0.057040773,0.008673234,-0.022397114,-0.07371331,0.04647373,0.014621443,0.008399103,0.041993666,-0.03262435,-0.02475842,0.0055003185,-0.027884865,0.0542187,-0.006475844,-0.016700542,-0.0149122,0.07785257,-0.090663776,-0.025329039,-0.028746791,-0.09196137,-0.0314701,0.080686495,0.053138107,-0.058593303,0.09133809,-0.017067222,0.0040194783,-0.03826946,0.034493715,0.04158372,-0.015578605,0.02285686,0.015310043,0.050272107,-0.029161014,-0.029881317,0.012184875,-0.003261829,0.014755,0.05010416,-0.0035176876,0.05297287,-0.0054940553,0.034408666,0.062004205,-0.016136989,0.07779444,0.023423916,-0.12558357,-0.016425775,0.072691895,-0.049657993,0.030944051,0.0020225823,-0.03052695,0.026632061,0.102852665,-0.014495646,-0.034071397,-0.04777474,-0.03164071,0.028093895,-0.026071953,-0.002635709,0.047729317,0.007333078,-0.030767318,-0.05046676,0.04847346,0.05719919,-0.068719625,0.05782144,0.07069819,-0.04574417,0.018396497,-0.090887114,4.8024094e-33,0.06887589,0.11173562,0.016980825,0.010603119,0.021260584,-0.004884963,-0.057871945,0.023670645,-0.07622231,-0.043009195,-0.02536796,0.012701169,0.08672634,-0.034597207,-0.0601618,-0.013320446,-0.078412674,0.02715332,0.07047093,0.038340617,0.053315066,0.01722297,-0.020095661,0.07147172,-0.0035691205,0.0844921,-0.028988129,-0.0026937292,-0.009434163,-0.0151149025,-0.049380917,-0.116002224,-0.046263885,-0.0114556635,0.055302516,-0.083523475,-0.03771584,-0.011932203,-0.026845677,0.022868684,-0.015778167,0.015533426,0.010849861,-0.022322187,0.056039654,-0.04780447,-0.061214354,0.05615777,0.005479603,0.08724365,0.0039204303,0.027974263,0.09466,-0.032093495,-0.07321081,-0.06884271,-0.015427813,-0.01501585,0.04251279,0.063785814,0.04772219,0.0713197,-0.04295812,-0.012032672,0.038895387,-0.0043144096,-0.010103697,-0.09472507,0.023252256,0.11147713,-0.0049382304,-0.050191604,0.03486261,0.056176018,0.025824798,-0.040246822,-0.033924095,0.07940061,-0.01666849,0.009119584,0.021214614,0.045155484,-0.017217072,-0.019220382,0.012151943,0.006330658,-0.017755892,-0.015245449,0.01969548,0.07360376,0.026373392,-0.11135615,-0.00017789523,0.0069488827,-0.027136715,-4.16128e-33,0.11070707,-0.02606932,0.027017243,-0.061015707,-0.08442197,0.083146885,0.079389654,-0.010154315,0.09539041,-0.010332674,0.073792025,0.036023315,0.03054003,-0.011770284,-0.015320006,0.049611315,-0.04700115,0.026788175,0.0057786857,0.005147781,0.09894896,0.052824054,-0.017412214,0.072427355,0.11174657,0.07015788,0.022364542,0.01073426,-0.012388705,-0.0068314713,-0.051885933,0.003683735,0.006123298,0.005753383,-0.08550919,0.03891992,-0.13758974,0.03829329,0.015381722,0.02841816,0.0191245,0.09009919,0.04062623,-0.0075086723,-0.0017979001,0.018903747,-0.035921354,0.036604296,0.02695601,0.0050481455,-0.02489282,0.044186015,-0.0896969,-0.012912887,-0.011916678,-0.006390016,0.02129353,0.09000747,-0.019314934,-0.0057089357,-0.028813584,-0.043937176,0.093604,0.04188921,0.031759895,0.035484675,-0.0053474875,0.05021206,0.00069654,0.030564487,-0.0022947337,0.003953628,0.009581082,0.027345067,-0.013417039,0.007666174,-0.09521504,0.034147255,-0.004024282,0.03576948,0.014248325,-0.00041609255,-0.017145714,-0.05795482,0.027362099,-0.028851578,0.06970415,0.10716543,0.022542398,0.008322607,-0.0017127674,-0.056664873,-0.030802423,0.023784148,0.09534008,-4.8344077e-08,0.043044493,-0.023066355,0.024807407,-0.0518187,0.04650508,-0.014624107,0.018689446,-0.028555606,0.11150414,-0.03537732,0.020613087,0.040095042,0.0071825306,0.035409734,0.015878908,0.013356361,-0.10431216,0.0076658027,0.018437251,0.0068432763,-0.056432385,-0.028003054,-0.1531413,0.021657176,0.0831343,-0.05852589,-0.014183528,-0.0588261,0.021750456,-0.023168452,-0.0061958185,0.0026650787,0.027501615,-0.04579511,-0.055370428,-0.025143374,-0.09932393,0.0052518835,-0.092037,0.02736527,-0.053228915,-0.0984597,-0.035404816,0.02061239,0.02683366,0.06593921,-0.034180608,0.00057403353,-0.047533542,-0.05026416,0.061217006,-0.039202698,-0.017663717,-0.12302289,-0.11078976,0.05085076,0.020163337,-0.059397917,-0.026634132,-0.08281906,0.004358519,-0.0012490336,0.18881968,-0.06193799 +2.7.1.158,"The enzyme can also use Ins(1,4,5,6)P4 [2] and Ins(1,4,5)P3 [3] as substrate. Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolysed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment [5].",384,0.99999994,-0.06344915,-0.013803556,-0.11308267,0.023022752,0.10773948,0.03714978,0.047729775,0.035886217,0.037737187,0.033436324,0.07646653,0.02553793,-0.071034394,0.031617478,-0.03271791,-0.005773598,-0.020556966,0.03432211,-0.042094223,-0.08249873,0.10207115,-0.041500963,-0.06275109,0.012312059,0.041797567,-0.036746196,0.019620901,0.0077461437,0.051857106,-0.06647033,-0.04504271,0.02570015,0.08223725,-0.07555989,-0.008986225,0.17250502,-0.034296636,-0.10393577,0.021083292,-0.045777768,0.13172816,-0.01751212,-0.029982256,0.048168704,-0.07990771,-0.02049779,-0.013374875,0.043437246,0.08486752,-0.075179644,-0.05242942,-0.007772885,0.002298211,-0.022328738,-0.053661298,0.0141582275,-0.018216114,0.09098847,-0.017921899,0.042090833,0.07698548,0.06366085,0.002754986,0.022847833,0.017873822,-0.02021494,0.020764094,0.05891251,0.03445812,-0.054217696,0.019331729,0.029548982,0.016307395,0.025257003,0.0056097144,0.058722064,-0.030391634,-0.0061553027,0.01699248,-0.020474104,-0.018780388,0.0040491135,0.030854054,0.030073026,-0.020924458,0.033194248,-0.029887917,0.035622366,0.016102383,0.020131756,0.06391265,0.010721361,-0.06649291,-0.015050111,0.0030789154,0.055939887,0.020543246,-0.06782237,-0.019496612,-0.04831897,0.07733977,0.06110051,-0.058943436,-0.015946224,-0.023498505,-0.0072832727,-0.051818382,-0.05010487,0.0003117959,0.09123613,-0.042688698,-0.04953405,0.019269425,0.0007536337,0.0034463333,0.0711752,-0.050159696,-0.0015208581,0.030385695,0.020601783,-0.009989293,-0.035446752,0.039944116,0.086677276,-0.106508106,-0.006790113,-0.035867043,-3.0994902e-34,-0.012506712,-0.00829836,0.011087204,0.0052929316,-0.07345492,-0.044391822,0.013336589,-0.042893715,-0.05234298,-0.09484169,-0.13473798,-0.06717033,0.020095663,0.0073185107,-0.007631455,-0.054408353,-0.060457133,0.051774923,0.07017599,0.11385199,-0.014123167,0.0020410041,-0.089241244,0.02481763,0.05702584,0.052055236,-0.040383365,-0.026796198,0.022631943,-0.0041685603,0.06810912,-0.032106295,-0.10515479,0.023339609,0.035408203,-0.069803186,-0.044968832,-0.019578777,-0.021898637,0.034279715,0.03516899,0.0047146254,0.079475194,0.016083961,-0.006908495,-0.02863997,-0.045935594,0.011761587,0.032773096,-0.01545839,0.052457057,0.0035144615,0.0838959,-0.06715717,-0.06695013,-0.0011403373,0.031874992,-0.013636223,0.032212418,0.035837397,-0.034723837,0.0088452445,-0.042322915,0.06521382,0.023418201,0.02125274,-0.120085016,-0.019847075,-0.0012939682,0.07287054,-0.065379456,-0.07468382,-0.021815991,-0.00011547039,-0.025161972,-0.03489546,-0.06881427,0.028248914,-0.07567397,0.062566236,0.059948277,-0.10728926,-0.01968276,-0.021748513,-0.11133639,0.020172339,0.0038844405,-0.019878838,0.05957567,0.021579402,0.10110821,-0.058989316,-0.01387003,0.003765676,-0.025365686,-2.1711807e-33,0.078083314,-0.002563852,0.039689023,-0.038384523,-0.11009413,0.06442456,0.060914006,-0.019030541,0.07601209,0.015037291,0.025529038,0.01706108,0.015708068,-0.0032346754,-0.056783225,0.06288754,-0.033296544,0.057196923,0.005410679,0.016592469,-0.09109071,0.043828845,0.03233543,0.06477476,0.011338559,-0.006436951,0.005362926,-0.014868785,-0.04097712,0.05008742,0.016124982,-0.045079313,-0.050769478,0.017234512,-0.053239778,-0.06521211,-0.041117,-0.10025875,-0.025259461,0.05178728,0.01147187,0.11404307,0.054511108,0.034005396,-0.04382002,0.026073363,-0.021557301,0.08790031,-0.026373332,-0.008807134,0.0011672428,0.05768301,-0.0393306,0.06225998,0.03217595,-0.019879889,-0.0043662535,0.099329054,-0.0617218,-0.030261924,-0.05454515,-0.104827926,0.037365302,-0.0401028,-0.016660498,0.05636695,-0.0239126,0.06554389,-0.054271504,-0.0035079431,0.011753221,0.017681463,0.059593517,0.012328183,-0.04119665,0.013783079,-0.03578498,-0.0080708,-0.021317307,-0.04148054,-0.06660061,0.009810349,-0.09166717,-0.058441002,-0.004124749,-0.08914107,0.06780849,0.10487749,0.049123384,0.04591005,0.018996349,0.01863445,-0.011783788,0.05689449,0.13045955,-4.1332484e-08,-0.0075508724,-0.05635463,0.051943313,-0.050522227,-0.045911588,-0.04985604,0.057381827,-0.013791619,0.09073523,0.010020728,-0.07043878,0.050171733,-0.0036740873,-0.044339944,0.04265845,0.011311899,0.010502374,0.08984608,0.005729807,-0.019262305,-0.0011556708,-0.09350425,-0.09279282,0.016151566,0.0636344,-0.029945645,0.061522644,0.012105603,0.055856705,0.028069535,0.01841963,0.015496045,0.0017212159,-0.015024168,-0.040670685,0.127187,0.0021213286,0.007374107,-0.025069129,0.038521115,-0.045817964,-0.08507522,-0.03115564,-0.04771679,-0.04309381,0.041841906,-0.018597048,0.07823155,0.01922706,-0.013094935,-0.053443585,-0.044959873,0.007576331,-0.08405567,0.008713384,-0.003478836,-0.045127533,-0.0061275,0.0007873765,-0.020932868,-0.06068766,0.02713763,0.15939863,-0.06738506 +2.7.1.159," In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2]. The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase. ",384,1.0,-0.073085226,-0.05483907,-0.061085258,-0.042773213,0.069937244,0.020398898,-0.008544652,0.040585995,0.056716308,0.061991777,0.051981766,-0.03621784,-0.103724726,-0.034135163,-0.03157467,-0.0026182255,-0.07012798,-0.015002438,-0.02664132,-0.054913197,0.029542452,0.019010702,-0.00010042179,0.006206769,0.0076886546,-0.042082507,0.07730588,0.056519788,0.0033948042,-0.107488856,-0.06279729,0.026018308,0.00830789,-0.06200461,0.032175336,0.15572149,-0.025800364,-0.106928796,0.04305293,-0.014000915,0.09191101,-0.03187213,-0.025825744,-0.04007729,-0.009705899,0.001193731,-0.00034624306,0.039566338,0.086980276,-0.032614328,-0.010280282,0.016424125,0.020682182,-0.011614653,-0.05172374,-0.024036175,-0.07568957,0.018074038,-0.005606185,0.061087176,-0.00022696293,-0.013221229,0.041778777,0.056619897,0.03971023,-0.035400074,0.054749373,0.036998894,-0.031675413,-0.013480866,-0.086199,-0.00040472543,-0.027798278,0.07377967,0.0030557103,0.055048175,-0.0037371553,-0.0738189,0.0106695555,-0.031226125,0.020656923,0.004608465,0.03399016,0.02662735,0.03637725,-0.043299135,-0.0012849154,0.082111955,-0.018900754,0.09185183,0.06621624,0.006930128,0.013601066,-0.025141774,-0.003479545,0.08769792,-0.042418804,0.11982802,0.018801665,-0.076986104,0.006376467,0.07783849,-0.06901474,-0.08064639,0.06028083,0.0404099,0.0011532418,0.0347148,0.07025068,0.07700485,-0.0339858,-0.07870513,0.0044964133,-0.00091331924,0.06682549,0.071371615,-0.0072398847,-0.04736517,0.027997503,0.027376518,-0.003802239,-0.017829137,0.034554515,0.11589221,-0.10381263,0.04461427,-0.06369666,2.3106184e-33,-0.0029991227,0.036900613,0.0073182806,-0.0045232954,-0.029753724,0.021889817,-0.057584215,-0.026676573,-0.113191426,-0.045263734,-0.09570056,-0.054464392,0.039590873,-0.009457474,0.038046293,-0.021221677,-0.00018382902,0.03368338,0.057562657,0.015198909,0.025496636,0.031197255,-0.057338692,-0.0009095019,0.063830175,0.095097736,-0.058282413,0.00054375024,-0.034112364,-0.036705174,-0.006643512,-0.0244988,-0.022640217,0.0468925,0.04446036,-0.083746575,-0.0104342345,-0.009608759,-0.005479383,0.07537078,0.00656157,-0.0036370456,-0.029227186,-0.023222785,0.02284684,-0.004404373,-0.03971087,0.003974599,0.079784736,-0.03275983,0.035316993,-0.021316765,0.12205177,-0.05964935,-0.007947532,-0.014270545,-0.053460408,-0.00016847781,0.06808582,0.07654588,-0.07067559,0.081357464,-0.026058348,0.10483339,0.0101468945,-0.019234164,-0.117258735,-0.09436284,-0.06278535,0.056699276,-0.071396135,-0.036550336,0.03660471,-0.064781085,0.039745137,-0.013153143,-0.076135516,0.015332058,-0.079411276,0.09509077,-0.014271524,-0.13039288,0.012801434,-0.04608165,-0.033763282,0.028801987,-0.005998272,-0.018264063,0.043292336,0.027529716,0.11815912,-0.062369388,-0.10660591,0.052071013,-0.011003294,-4.8015278e-33,0.09169398,0.027960645,0.07499116,-0.09894895,-0.09520774,0.12119984,0.11016504,-0.07981013,0.015328394,-0.009494442,0.042668585,-0.061491013,0.014240895,-0.061377,-0.024709681,-0.03370652,-0.015506711,0.12223741,0.044955723,-0.0028773427,-0.052760392,0.023976771,-0.024310378,0.076995246,0.035873063,0.0248019,0.001655067,0.018314002,-0.018075567,0.0075114416,-0.08182191,0.013475048,-0.039739896,0.008186244,-0.024300158,-0.023780853,-0.06363117,-0.04900844,0.011845087,0.016342929,0.036556493,0.10629211,-0.03159814,0.025201946,-0.025998749,0.033909358,0.0070394753,0.04943781,-0.050912336,-0.030149387,0.03386166,0.043786645,-0.042077586,0.072730176,0.024866827,-0.013237991,0.0024280434,0.025963869,-0.0037172888,0.003969677,-0.045766618,-0.07949656,0.038142577,-0.03869122,0.054850254,0.050604098,-0.024618654,0.053490568,-0.0015861501,-0.008805218,0.03225438,-0.007748066,-0.013141268,-0.04204635,0.0043672216,0.033373,-0.04677279,-0.06082769,0.020719677,-0.073419854,-0.040998276,0.0077509605,-0.06961739,0.01707262,-0.019601714,-0.03276644,0.05046768,0.09938068,0.023614442,0.048396256,0.017716557,0.01866921,-0.042711362,0.049925447,0.030987639,-4.9948614e-08,0.04145831,-0.049097978,0.054280363,-0.061693132,0.06292118,-0.02784231,0.05548176,0.051967476,0.05871686,0.023644477,-0.023212815,0.04853766,0.05285067,-0.05218254,0.08580116,-0.03501898,-0.010640418,0.071716614,0.014237751,-0.023254352,0.00719349,-0.0845136,-0.09929963,0.07738215,-0.0011593434,-0.073768325,0.027876966,0.060344838,0.069987014,-0.06461327,-0.06496718,-0.048482697,-0.028422575,-0.020831201,-0.0150263645,0.042531885,-0.045096155,-0.06348538,-0.06681064,0.018478021,-0.06397447,-0.063600756,-0.023448985,-0.031740155,-0.050733324,-0.009968168,0.047682635,0.00012207746,0.039736163,-0.05011152,-0.024836326,-0.015796604,-0.00581939,-0.058935218,-0.001903589,-0.017916238,-0.07451852,-0.031865433,0.004019927,-0.017071672,0.02825626,-0.01616579,0.11520957,-0.05926906 +2.7.4.22,"This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1].",384,0.99999994,-0.06819507,-0.013025326,-0.06053547,-0.07318254,0.05375854,0.02321467,-0.01052544,0.049899187,-0.016557837,-0.013982253,0.024893299,-0.0105511835,-0.09623311,0.03585963,-0.036130317,0.095477425,0.01838399,0.034877457,0.024525974,-0.038844142,0.028192904,-0.027607786,-0.0010769848,-0.014503277,-0.0386107,-0.0093833245,0.07359294,0.09957533,0.014911709,-0.10683633,-0.023002928,-0.09954373,0.06966094,-0.052634273,0.014695872,0.08340606,-0.08227244,-0.10826992,-0.027060922,-0.01691251,0.054701738,-0.0032481286,-0.04532566,0.02403663,0.015920654,0.024573931,0.017984789,0.021457946,-0.043863915,-0.011184216,0.015175447,0.02101164,-0.012712723,-0.037592635,-0.011022795,-0.0025144708,-0.06750586,-0.004400225,-0.018314106,-0.06094682,-0.010218194,-0.015405935,0.002188069,-0.03144908,0.059162263,-0.013306076,0.0123886885,-0.066950575,0.03964144,-0.036174454,-0.05844257,-0.12420417,0.027441768,0.0963617,0.021382459,-0.017156748,-0.04929712,0.04044298,0.06349914,0.0074965474,0.022672646,-0.002650444,-0.008930261,-0.023035245,0.02614328,-0.02585762,-0.018273244,0.031113049,0.05296923,0.031106893,0.04477362,0.005012192,-0.015659828,-0.027118454,-0.081522614,0.020581229,-0.009833212,0.045879297,-0.020093301,-0.0484324,0.051084824,0.054879654,-0.058174446,-0.002546818,-0.046448104,-0.12123237,0.017959693,0.022257682,0.0027976618,-0.03501556,-0.043353494,0.08784067,-0.0028531416,0.012847059,0.020088634,0.021196796,-0.0045496463,-0.058821518,0.008348698,0.04957237,-0.04248303,-0.051781602,-0.042346504,0.114685826,-0.048481796,0.014062208,-0.10758635,3.4941104e-34,-0.0009687522,-0.004845511,-0.020864215,-0.09507327,0.0024224455,-0.01491415,-0.0554602,-0.053390127,-0.05431257,-0.097820796,-0.044076048,-0.084415495,0.035248242,0.04963859,-0.05763393,-0.062211484,-0.016404336,0.0508685,0.09351631,-0.051962573,0.060763586,0.09961207,0.016115911,-0.004506793,-0.0040040854,0.10805023,-0.045260016,0.028703475,0.055338938,0.0136931185,-0.047420718,-0.07874686,-0.08200108,0.03502824,-0.039305072,0.025393348,-0.07185357,-0.084806435,0.04656805,0.079212606,-0.02285672,0.007512299,0.010097596,0.029831024,0.038642686,-0.035782285,-0.07811107,0.11439487,-0.0206819,0.018099394,0.052811123,-0.08532939,0.023333525,-0.027217261,-0.004284857,0.013876788,-0.1251835,-0.023288593,-0.0036702259,-0.014020321,0.039228242,0.023145277,-0.048480462,0.04319412,-0.017395213,0.016648857,-0.060204275,-0.025626268,0.083024025,0.14423068,-0.062103286,-0.01906723,0.094140716,0.044493835,-0.002117377,-0.07974829,-0.030036172,0.11002469,-8.826577e-05,0.106646195,-0.06250731,-0.022183953,-0.04726954,-0.018816533,-0.025466502,-0.03142051,0.031800535,-0.034941543,-0.014097256,0.052969143,0.072022915,-0.009748201,-0.0022041162,0.08635784,0.017739391,-2.7991378e-33,0.12875143,-0.095720984,0.03548971,-0.022005506,-0.058502346,0.054510083,0.017183246,-0.08967369,-0.0056831874,-0.019306585,0.041416828,-0.05352503,0.03384101,-0.05485013,0.009044124,-0.018172586,-0.014976151,0.1263853,0.0076541216,0.01744326,-0.042124573,0.013920149,0.026381932,0.05168462,0.009437162,-0.036036663,-0.006363885,0.036704127,0.049820412,0.006474957,-0.036758255,0.07374591,-0.10184141,-0.02127526,0.022107603,-0.022651039,-0.044887766,0.047431327,-0.014143307,0.022558752,0.05059749,0.08615456,-0.073572166,0.06007268,-0.018009832,0.15002027,0.012702669,0.010222063,0.008002789,-0.09431627,0.059097953,-0.0122022545,0.00892276,0.012016396,0.003732827,0.034336064,0.0056770453,-0.02282317,-0.007298909,0.017849356,-0.045294497,-0.053819835,0.042561967,-0.0030145638,0.057023678,0.122614786,0.0015109369,0.020143783,0.0021694538,0.062240694,0.03344888,0.00783994,0.051792655,0.021833904,-0.0778506,0.056100864,-0.034475297,-0.02598551,0.023016008,-0.050626114,-0.03526848,0.021444548,-0.026445672,-0.025265276,-0.038508456,0.0078111845,-0.0061100833,0.09132204,0.058018114,-0.0143893175,-0.0031022558,-0.039300457,-0.03581899,0.056025475,0.056490343,-4.0948034e-08,0.026478916,-0.06260284,0.004465021,-0.048143975,-0.014290617,0.10406512,-0.03323329,-0.030872976,0.042871337,-0.015550358,0.039699595,0.0464082,0.0131382495,-0.05929149,0.062367175,0.002700082,0.03955536,0.08060528,0.037468217,-0.039601568,-0.07763278,-0.012867894,-0.06659173,0.068392165,0.061893687,-0.0065793223,0.018529968,0.081218176,0.016028501,-0.082207836,0.011398501,-0.037607912,0.020794032,0.03836774,0.020526515,0.069010526,-0.014142339,-0.055362277,0.0004853462,0.03707224,-0.0023925998,-0.032150295,-0.02976381,-0.01711307,-0.02245707,0.03367497,0.05000222,-0.02782067,-0.09506371,0.026473165,0.023986867,-0.00051457493,0.015951877,-0.04812655,-0.052169207,0.03793021,-0.034734804,-0.14693527,-0.10066753,-0.062431525,0.02966969,0.06791723,0.13750745,-0.032934006 +2.7.7.63," Requires Mg2+. Both 6S- and 6R-lipoates can act as substrates but there is a preference for the naturally occurring R-form. Selenolipoate, i.e. 5-(1,2-diselenolan-3-yl)pentanoic acid, and 6-sulfanyloctanoate can also act as substrates, but more slowly [2]. This enzyme is responsible for lipoylation in the presence of exogenous lipoic acid [7]. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [6]. This enzyme attaches lipoic acid to the lipoyl domains of these proteins, converting apoproteins into holoproteins. It is likely that an alternative pathway, involving EC 2.3.1.181, lipoyl(octanoyl) transferase and EC 2.8.1.8, lipoyl synthase, is the normal route for lipoylation [7].",384,1.0,-0.09133044,-0.115954824,-0.08058955,-0.051226474,0.036181107,-0.03114401,-0.093953334,0.021466693,0.006160383,-0.066238284,0.041928876,-0.044626333,-0.073443316,-0.030057136,0.055361684,0.036422137,-0.033496063,0.06624306,-0.012097986,-0.03682943,0.07738508,0.021209301,-0.0026460274,-0.035983995,-0.0045390064,0.025343254,0.018234903,0.019852452,-0.052265644,-0.057127368,-0.0040227496,-0.06340861,0.030015543,-0.08439046,-0.04509757,0.09737462,-0.05722596,-0.0032189027,0.015584645,0.0016320003,-0.006611882,-0.02328606,-0.045771636,-0.070928946,0.050403725,-0.13996443,0.039891217,0.013291622,-0.016316686,0.029041717,-0.034742996,-0.033519056,-0.058917157,0.038950242,-0.004119501,-0.004628851,-0.0057082777,0.031971198,-0.04550886,-0.016074311,-0.049460825,-0.02264188,0.030086111,-0.022259332,-0.0728641,-0.08140938,0.07061105,-0.07538996,0.026418315,0.0032432938,-0.100522555,-0.072389014,0.033124145,0.01913065,-0.036052458,0.07600061,-0.042705595,-0.015961204,0.044025153,-0.018467125,0.081538916,-0.04892482,-0.019709129,0.07812159,0.013627008,-0.05528558,0.0022264048,-0.032647748,0.003463387,0.066979915,0.07135925,0.040079016,-0.014186365,-0.014966735,-0.04609222,0.006499192,-0.006869369,0.060866777,0.022471977,-0.038945373,0.016584713,0.053333484,-0.06565493,-0.024900366,0.019176599,0.011162354,-0.010881204,0.061795674,-0.036655232,-0.01754667,-0.00053904473,-0.01532548,0.04381218,0.054347467,0.023096,0.13412385,-0.035810012,-0.0965479,-0.015049648,0.030319832,-0.008805807,0.047949914,0.07100903,0.03904443,0.013827076,0.015808158,-0.0954972,4.403283e-33,0.050009206,0.03812807,0.01374627,-0.003320865,-0.04661214,0.034600154,-0.12077545,0.04031545,-0.025773384,-0.055134386,-0.026107406,-0.064001575,0.08301472,0.029273376,0.025521845,-0.03439242,0.045296993,0.09513025,0.10642955,0.00042723134,0.049665216,-0.037928015,-0.027396383,-0.043002453,0.022370122,0.08808019,0.008952082,-0.010617138,-0.0016218439,0.009704298,-0.023602426,-0.10964621,0.014717562,-0.0024324819,0.055214014,-0.0489747,-0.05637557,-0.033031736,-0.02096118,-0.009910191,0.019730575,0.0094354795,-0.039559104,0.011152196,0.02503236,-0.06655577,-0.013255835,0.10647299,0.06338421,0.028904838,0.043163083,-0.05334533,0.10617489,0.020800592,-0.008597386,-0.011333253,-0.08907408,0.020210443,0.06329664,0.045595523,-0.03451624,0.05108076,-0.06867354,0.018585136,0.055338018,0.030803261,-0.12223581,-0.046502277,-0.07641966,0.050131664,0.051210567,-0.025978008,0.07217999,0.07705612,0.015873311,-0.029077496,4.6371765e-06,0.056084987,0.029063823,0.009014453,0.017556123,0.06372441,-0.011493576,-0.05755402,-0.08083099,0.023935322,-0.05610528,-0.004798804,0.026970519,0.076031394,0.041509382,-0.07394557,-0.11703023,0.01505888,-0.015082642,-4.2666547e-33,0.06248284,-0.0652724,0.030318195,-0.05613565,-0.010085745,0.08700722,0.112530574,-0.03417507,0.1048363,-0.09055573,-0.0053547695,0.036766123,0.062066376,-0.054977514,0.005787719,0.03531089,-0.04239577,0.048381515,0.028469454,-0.05192819,0.05808245,0.014206329,-0.050624557,0.095921345,0.03642704,0.055554647,-0.007763169,-0.029458646,0.01963381,0.09264129,0.0049730004,0.03170726,-0.049026597,0.009168708,-0.0031066823,0.10522745,-0.039938938,0.019180233,-0.038584247,0.08755488,-0.047506347,0.020458808,0.04702942,0.0047845677,0.057247214,-0.0038040853,-0.038983982,0.060474645,-0.023993747,-0.0386735,0.020344498,-0.01352036,-0.061026905,0.056046907,0.09699095,0.044196602,0.030795392,-0.026104616,0.0050202296,-0.069184236,-0.021704085,-0.018858055,0.0015126728,-0.036299158,0.026366103,0.084085055,0.06719705,0.03567379,-0.019363657,-0.0032951408,0.045213334,-0.013106434,0.002081642,-0.04046764,0.014841426,0.04878592,-0.038613427,0.014798664,-0.037671976,0.0023679596,0.004065064,-0.0051825675,0.034859594,-0.05615786,-0.007270469,-0.04939229,-0.007465016,0.0809479,0.01521936,0.018086549,-0.027947495,-0.09706818,-0.0681659,0.07329649,0.10097062,-5.122931e-08,0.016441759,-0.07285104,0.10064069,0.015939847,-0.017848136,0.021376,0.06872941,0.0023949984,0.027419943,-0.05445294,-0.02761055,0.09013313,0.073777445,-0.0031091848,-0.014618276,-0.0020866212,0.044354178,0.030081892,-0.030837683,-0.07423008,-0.046257734,-0.08045989,-0.09445038,0.016648712,0.082081534,-0.100212835,0.011171492,0.019724742,0.026255304,-0.06670532,0.02918553,-0.028617797,0.020398365,-0.049686182,0.01838215,-0.035620544,0.019237548,-0.03252974,-0.08337921,0.08971538,-0.014121086,-0.07281692,-0.04852119,-0.014237048,0.046657283,0.030197177,-0.07083871,0.049513068,-0.018090118,0.02942275,0.0018266425,-0.0048134043,-0.0005640126,-0.0045550102,-0.04813615,-0.0045534866,-0.008172807,-0.06176715,0.031036008,0.0063505652,0.037340857,0.016236885,0.20621905,-0.047188047 +2.7.7.90,"The enzyme, characterized from the bacterium Shewanella oneidensis MR-1, acts on the 8-aminated from of 3-deoxy-alpha-D-manno-octulosonate (Kdo). cf. EC 2.7.7.38, 3-deoxy-manno-octulosonate cytidylyltransferase.",384,1.0,-0.06465957,-0.045004465,-0.07630021,-0.043130495,-0.024129264,0.010324217,-0.023785971,0.02585068,-0.009480626,0.08352716,0.04941916,-0.03539376,-0.052128077,0.036113836,-0.039797354,0.05908211,-0.10122491,0.031470876,0.02405493,-0.014030783,0.09753604,0.063136116,-0.005570687,-0.01830581,0.054134592,0.06681009,0.017316038,0.020811005,-0.043909498,-0.10128688,-0.027192596,-0.059483882,0.07693436,-0.04310923,0.11777745,0.10962107,0.011113937,-0.047238242,0.06773758,-0.018010275,0.034317832,0.011100375,0.08109924,-0.106794,-0.098218225,0.0019803322,0.031764634,0.11100435,0.07322337,-0.036366884,-0.0077330167,-0.021641104,-0.01574354,0.008882896,0.02201747,0.031148763,-0.051637698,0.021006858,-0.022560196,-0.013088473,-0.030772844,0.037355658,0.042114735,0.053309444,0.08023262,-0.06788365,0.022331169,-0.116233826,-0.0238791,-0.03835192,-0.0047373017,-0.09270468,-0.026985003,0.0046463315,-0.01467272,0.017814672,0.008590308,-0.045850273,0.042758245,0.007972291,0.025420574,-0.043425,0.06488691,0.025221378,-0.051933236,-0.0030319898,-0.044601217,0.025360804,0.070293,0.038176596,0.013233039,-0.0050922376,-0.019180775,-0.055093404,-0.006061526,-0.017653588,0.016473597,0.0629269,0.03197207,-0.027381614,0.03810845,0.061407145,-0.073152006,0.0012865198,-0.01669723,0.0019087073,0.010293937,-0.0064861006,0.036167115,-0.00883858,0.03205325,0.007600274,0.013037087,-0.056057062,-0.11588743,0.04424152,-0.0004587216,-0.024084292,-0.045524135,-0.04702485,-0.050687082,-0.038558614,0.039492942,0.07317425,-0.054670747,0.05457768,-0.09496543,-2.3301267e-34,-0.0071419217,0.039937522,0.0460275,-0.020325555,0.027622435,-0.029549263,-0.0197323,0.00907244,-0.046284523,-0.036480047,-0.116158076,-0.04217473,0.024129508,-0.011200352,-0.028947184,0.04162026,-0.008150196,-0.017847436,0.02561773,0.007259968,0.048059866,0.07762518,-0.039781537,0.00203263,0.062286366,0.06446702,0.049171343,0.02514281,0.073546894,-0.009384527,-0.0031020027,-0.06461166,-0.13912296,-0.054201744,0.020007143,-0.037808716,-0.04607617,-0.053406253,0.03491585,0.065104246,-0.055320494,0.00058346975,-0.0324063,-0.06720162,0.008957428,0.0022579439,0.010721401,0.035610322,0.007677691,0.00901465,0.04329036,-0.0115950545,0.053743847,-0.056674823,-0.09751545,0.0070123626,0.057801798,0.027930977,0.115869,0.072190486,0.018276874,0.041690998,-0.005708793,0.0019737524,0.072286285,0.0075705806,0.016427638,-0.05724143,0.008300498,0.031238833,-0.11545306,-0.059919626,0.048249703,-0.054571565,0.038941465,0.0145942215,-0.04609274,0.0019424103,0.080947004,-0.011055386,0.0439796,0.0065284944,0.013226571,-0.03507767,-0.009058781,-0.0112638585,-0.036819853,-0.08384796,-0.05217401,0.07709654,0.0861763,-0.07443878,-0.07159275,0.052023698,-0.025269458,-3.1533565e-33,0.019317105,-0.083186075,0.06556587,-0.052008692,-0.06693862,0.06492317,0.014014761,0.074259475,0.071185775,-0.020710444,0.08463873,-0.014748538,0.029142117,-0.050477415,0.011385149,-0.010388126,0.030781442,0.09723818,-0.06078157,0.03575418,-0.0274853,0.07824872,-0.015958453,0.020835308,-0.050441496,-0.024146743,-0.019821249,0.052939076,0.068092614,0.03380926,0.005457788,0.04007614,-0.01882256,-0.04828979,-0.04371112,0.03404812,-0.04726066,0.00031740693,0.085567236,0.07006471,-0.013238326,0.030262947,0.039571416,0.038889807,0.00362027,0.06371064,-0.10324764,0.0376626,-0.051759277,0.022228174,-0.043769013,0.053353887,-0.052791275,-0.02620641,0.052957155,-0.018891327,0.04676064,-0.0068546296,0.0021794788,-0.022595717,-0.07725557,-0.10236912,0.0715854,0.030508239,0.014144782,0.13899529,-0.031176418,-0.021354612,0.041052844,-0.0035209504,0.049803164,-0.027237082,0.012740509,0.003003922,0.013872732,-0.0020784792,-0.10762355,-0.04955299,0.060965676,-0.044969503,-0.015363962,-0.06475726,0.015248492,-0.036972992,0.07026166,-0.11430103,0.13371144,0.10251386,-0.0013969355,0.046126388,0.0072339396,0.0051912777,-0.045243744,0.013899013,0.019279374,-4.0724025e-08,0.008878933,-0.12806767,0.104547426,-0.056486424,0.015283068,0.082707494,-0.023231313,0.024276527,0.10053912,-0.06267997,0.018164353,0.050794702,-0.017624585,-0.05214367,0.001290388,0.013746555,-0.10964682,0.002795212,-0.0029316135,0.020157326,-0.09755231,-0.0051175547,-0.037721958,-0.036196683,0.039171685,-0.026953246,0.04125841,0.040871892,-0.03341885,-0.0413406,-0.034299202,0.048156474,-0.049932674,-0.03879873,-0.12662944,-0.058652267,-0.0077436706,-0.011802839,0.00023431744,-0.04616398,0.030844746,-0.021881161,-0.05074075,0.024828874,-0.0055233804,0.08081034,-0.011694896,0.05546345,-0.06504398,-0.05995045,-0.00058598525,-0.007122236,-0.016129423,-0.07298826,-0.085243575,-0.028948171,-0.0430678,-0.026936049,-0.02067254,0.012814951,0.03375007,-0.0055174497,0.12868622,-0.04282212 +2.4.1.243,"Inulins are polysaccharides consisting of linear or branched D-fructofuranosyl chains attached to the fructosyl residue of sucrose by a beta(2->1) linkage. This enzyme catalyses the transfer of the terminal (2->1)-linked -D-fructosyl group of an inulin chain onto O-6 position of the glucose residue of another inulin molecule [1]. For example, if 1-kestose [1F-(beta-D-fructofuranosyl)sucrose] is both the donor and recipient in the reaction shown above, i.e., if m = 1 and n = 1, then the products will be sucrose and 6G-di-beta-D-fructofuranosylsucrose. In this notation, the superscripts F and G are used to specify whether the fructose or glucose residue of the sucrose carries the substituent. Alternatively, this may be indicated by the presence and/or absence of primes (see {iupac/2carb/36#362::http://www.chem.qmul.ac.uk/iupac/2carb/36.html#362}). Sucrose cannot be a donor substrate in the reaction (i.e. m cannot be zero) and inulin cannot act as an acceptor. Side reactions catalysed are transfer of a beta-D-fructosyl group between compounds of the structure 1F-(1-beta-D-fructofuranosyl)m-6G-(1-beta-D-fructofuranosyl)n sucrose, where m >= 0 and n = 1 for the donor, and m >= 0 and n >= 0 for the acceptor. 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It is a member of the 'AdoMet radical' (radical SAM) family, all members of which produce the 5'-deoxyadenosin-5'-yl radical and methionine from AdoMet (S-adenosylmethionine) by the addition of an electron from an iron-sulfur centre. The enzyme contains two [4Fe-4S] clusters. The first cluster produces the radicals, which are converted into 5'-deoxyadenosine when they abstract hydrogen atoms from C6 and C8, respectively, leaving reactive radicals at these positions that interact with sulfur atoms within the second (auxiliary) cluster. Having donated two sulfur atoms, the auxiliary cluster is degraded during catalysis, but is regenerated immediately by the transfer of a new cluster from iron-sulfur cluster carrier proteins [8]. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [1,2]. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues) [4].",384,1.0,-0.07046665,-0.09078177,-0.121939056,0.09525168,0.073702015,0.036741365,-0.09280128,0.021550417,0.0025033997,-0.048194733,0.02258463,0.007750234,-0.09349575,-0.0042898906,0.011065996,0.093782775,-0.11833218,0.039746363,-0.06154803,-0.06636156,0.025748411,-0.060711823,-0.015775846,-0.051263623,0.012692169,0.10677946,0.06441961,-0.03005956,-0.06231216,-0.04216011,0.06514822,-0.022763515,0.05932967,-0.021954438,-0.03859705,0.11192265,0.026289275,-0.011651424,0.037333325,-0.015272168,-0.0421479,0.0348486,-0.050685287,-0.046899192,0.04225275,-0.12494655,-0.021230241,0.02721262,0.024438178,-0.03598284,-0.04222473,0.0004158737,-0.07080912,0.054199312,-0.010654664,0.023366822,0.03214597,-0.032150973,-0.0032306183,-0.0017903827,0.06932479,-0.062403426,-0.007422166,-0.02621802,-0.05741174,-0.035967465,0.11565083,-0.073413596,0.05071148,-0.024423566,-0.08645342,0.01604441,-0.03819799,0.005223261,-0.046931274,0.021600153,-0.021809828,-0.076749295,0.10172689,0.0013757128,0.047941875,0.0035950188,0.047119707,0.087469876,0.081847265,0.009007269,-0.014843529,-0.05769637,0.02226107,0.046024397,-0.04037619,0.010222054,-0.068970546,-0.036785692,-0.042567387,0.011342406,0.03708752,0.044085473,-0.026150152,0.004249351,0.0018212824,0.027182994,-0.07504809,-0.07626084,-0.0016111215,0.00815701,-0.015300997,0.08990404,0.013429015,0.07735357,0.012455534,0.029798152,0.028900364,-0.014992348,-0.013783803,0.1177567,0.017153053,-0.045396157,-0.032897796,0.037463684,0.027852299,0.065190375,0.039857533,0.075054154,0.0068239276,-0.02883532,-0.15941994,3.2489775e-33,0.076824725,0.08198222,0.05275662,0.020972442,-0.047601465,-0.044583254,-0.1308391,0.02096455,-0.010211636,0.029426033,-0.04113699,-0.06295215,0.13242294,-0.07455542,-0.014788871,-0.09385186,-0.011676195,0.039037794,0.06493941,-0.009132634,-0.03867525,0.017902175,-0.06809866,-0.028158447,0.00139082,0.06299918,0.012542973,0.003339261,-0.0017667963,0.045088876,-0.05647598,-0.044080935,-0.051914304,-0.019949952,0.0788401,-0.03422136,-0.034506638,-0.09371794,0.016725108,-0.009035823,0.012573018,-0.012730672,-0.00065929454,-0.021434639,0.041311033,-0.038090337,-0.072357535,0.05351014,0.082203545,0.05935713,0.00879972,-0.04779703,0.1342454,0.055400155,-0.079680406,-0.019529773,-0.023921173,-0.042405643,0.069958836,0.08662391,0.020739548,-0.018638102,-0.07210441,0.019680478,0.0027054534,0.004313253,-0.035382237,0.022290584,-0.0007322391,0.09981275,0.011419901,0.056605164,0.061489407,0.075870894,-0.023419296,0.01883254,0.057811078,0.10679196,0.056429643,-0.0006385248,-0.042164255,-0.021406924,-0.024290022,-0.0860481,-0.027499987,0.0019078208,-0.055585578,-0.046786357,-0.024156256,0.007114535,-0.017476026,-0.05175783,-0.037393775,0.008135593,-0.05012375,-5.1743965e-33,0.007944931,-0.05321163,-0.03783625,-0.09693829,-0.07686243,0.07670284,0.038424686,-0.023561541,0.01579788,-0.022858743,0.050095066,-0.00797175,0.07603869,-0.06871639,0.03985711,0.08152585,-0.027965164,0.016344726,0.064696394,0.006103458,0.07889342,0.044625316,-0.021648832,0.0711397,0.07134436,-0.024650736,-0.005862125,-0.030462667,0.093447365,0.07766952,0.08746696,-0.06656035,-0.02923188,0.00528206,0.009069395,0.0374173,-0.05167485,0.036276627,0.006342689,0.031784106,-0.01767754,-0.01334566,0.008730329,0.12512556,0.045010377,0.0019791601,-0.03068602,0.03616741,-0.0062788757,-0.07840554,0.03736415,-0.041768517,-0.037152335,0.024762513,-0.028267296,0.0705,0.032500513,-0.009890163,-0.04507083,-0.01683324,-0.023364356,-0.06569254,0.06423043,0.001040741,-0.027521817,0.028853174,-0.015122962,0.0077852546,-0.03604083,-0.019585937,-0.046250578,0.018933406,0.0051168837,0.03253246,-0.026746698,-0.014608236,-0.023132173,-0.0053708935,-0.04507355,0.042397816,-0.035807673,0.009433402,0.005627536,-0.10923546,-0.008804306,-0.08775288,0.05518505,0.11657576,0.018843591,-0.007806102,-0.06329685,0.012341763,-0.06330671,0.010837463,-0.0020004364,-4.8694393e-08,-0.024226226,-0.04475125,0.05701228,-0.013975042,-0.03026958,0.037170842,0.031890843,-0.04733671,-0.022509865,-0.06337656,0.010347415,0.14622587,-0.042141214,0.013260991,-0.008161471,0.009967507,-0.055011276,0.006038064,0.008285864,-0.027644387,-0.0319118,-0.055958644,-0.051798627,0.023001011,0.012516956,-0.056511555,0.03884384,-0.0004026832,0.0016096055,-0.04917666,0.02774657,0.031273052,-0.059972893,2.2927914e-06,-0.0899415,-0.011001136,-0.025206791,-0.026570823,-0.0457822,0.123736605,0.0085297255,-0.038826495,-0.091157764,0.059156667,0.0064161755,0.03253511,-0.02629335,0.03475011,0.006300211,0.048024915,0.019483132,0.01622933,-0.028617252,-0.023399403,-0.052378286,0.03200965,-0.03535126,-0.028511258,0.0732539,0.0027774188,0.008576506,-0.0047117346,0.116617166,-0.0019281842 +3.1.3.76,"Requires Mg2+ for maximal activity. The enzyme from mammals is a bifunctional enzyme: the N-terminal domain exhibits lipid-phosphate-phosphatase activity and the C-terminal domain has the activity of EC 3.3.2.10, soluble epoxide hydrolase (sEH) [1]. The best substrates for this enzyme are 10-hydroxy-9-(phosphooxy)octadecanoates, with the threo- form being a better substrate than the erythro- form [1]. The phosphatase activity is not found in plant sEH or in EC 3.3.2.9, microsomal epoxide hydrolase, from mammals [1].",384,1.0,-0.04111976,-0.06356059,-0.043196663,-0.023618126,0.07467308,0.016312683,-0.05515112,0.02453487,-0.03571438,0.019351771,-0.003562764,-0.026718704,-0.07131111,-0.0022173878,0.07198271,0.0077185407,0.0011794558,-0.008273898,0.006948092,-0.03350323,0.10525306,-0.019116284,0.0019313716,0.029495377,0.026449317,-0.06643609,0.07691552,-0.018832177,-0.02431192,-0.04831033,-0.044849478,-0.064315796,0.13138491,-0.035701603,-0.0095339995,0.05865299,-0.030159928,-0.040793665,-0.04576002,-0.04658297,0.043993663,-0.035890725,0.051699914,-0.06448486,-0.036455765,-0.0682414,0.078196816,-0.0417971,0.04469123,0.034975924,-0.0022822758,-0.04404926,-0.06051639,0.033311516,-0.052884888,-0.009503891,-0.05338406,0.039903723,-0.050279148,0.019466532,0.0016598824,-0.02008465,0.015653463,0.025207184,-0.015583256,-0.02218508,-0.015148384,-0.09846233,-0.091910005,-0.019946512,-0.004338178,-0.08830717,0.01770087,0.0033304174,-0.030858299,0.03178909,0.039964616,-0.035562586,0.019225473,0.022047954,0.039416093,0.011781425,0.0053776256,0.09637492,0.013072531,0.033742562,-0.05674834,0.01593044,-0.006945607,0.050006475,0.06958013,-0.0054223784,-0.009048553,0.0589082,0.004898019,0.106683835,0.008517879,0.018425614,0.034787178,-0.0467092,-0.06125857,0.099735975,0.0028154424,-0.06115212,-0.028319295,0.10689323,-0.046054777,0.03767751,-0.0016363384,0.0005650046,0.049229436,-0.04850428,0.017837843,0.06540772,0.043770123,0.013706134,-0.045768984,-0.11667304,-0.029481946,0.005035155,0.022503512,-0.0010687564,0.014363771,0.059560273,-0.020390088,0.046851967,-0.017435279,1.5499868e-33,0.013139334,0.0034605158,-0.01847136,-0.048511088,-0.013518871,0.088709325,-0.050211973,0.02540425,-0.054052923,-0.022667525,-0.04542618,-0.050178226,0.06772977,0.02499416,-0.007823373,-0.05553158,9.328766e-05,0.07042831,0.09350357,0.00952536,0.0069316206,-0.04439754,-0.077916026,0.0019452116,-0.032248326,0.087629765,-0.030296437,-0.0551166,0.07071133,-0.004535931,0.03232424,-0.11189522,-0.032764547,0.0034293015,0.04376064,-0.049820237,-0.009329509,0.0049644336,-0.04034436,-0.038231988,-0.016108619,0.028384222,-0.04164025,-0.01948896,0.02397072,-0.13742703,-0.04598361,0.08922716,0.08693269,0.03898455,0.020293834,0.006412837,0.10096755,0.043557655,-0.022424605,0.014610127,-0.041753657,0.052537177,0.079684965,0.030176159,0.007879225,0.06566018,-0.0154545475,0.019308824,0.025249284,0.055574197,-0.12512942,-0.10582011,-0.039195724,0.10851204,0.043984693,-0.0669881,0.025251757,-3.3497123e-05,0.034925688,-0.052872986,0.016975204,0.1208017,0.006844117,0.07348675,0.016383512,0.05781895,-0.013512355,0.022964228,0.017079715,0.025199894,-0.037319824,0.0052645933,-0.022040762,0.076690726,0.066500746,-0.05538849,-0.020987062,0.042609528,0.0037072827,-2.4667117e-33,0.091367304,-0.07351928,0.04699282,-0.094267204,-0.013765214,0.07827235,0.04741075,-0.015173859,0.039615683,-0.029889459,0.023803355,0.013584235,0.02159256,-0.06850308,0.05511059,-0.01949885,-0.0238771,0.09791838,0.012055257,-0.055456117,0.045191105,0.05935316,-0.024499238,0.12470563,0.061079975,-0.023220174,-0.024048936,0.039637245,0.006723446,0.0596923,-0.05784051,0.010307032,-0.07437337,0.03163137,-0.030711126,0.046601236,-0.09782957,-0.0034719978,-0.009431182,0.043444358,0.015611072,0.019327777,0.020064048,0.02485732,0.056767516,0.07195108,-0.09986003,0.13879043,-0.020822244,0.001527746,-0.050488144,0.0021137737,-0.054566763,0.005185193,0.051584456,0.06509814,-0.004002149,0.016418457,0.03442896,-0.09301199,-0.018239306,-0.030508488,-0.014596271,0.045138102,-0.02938629,0.05463338,0.010748403,0.0437614,-0.033965457,0.060457468,0.031594634,-0.01213565,0.005234318,-0.013051668,0.019630287,0.036707606,-0.025642889,-0.021835437,0.0006919885,0.027501427,0.047247306,0.082905754,-0.00932105,-0.0051462273,0.011770725,-0.045097634,-0.036822457,0.104676485,0.0399088,0.013194204,-0.038516853,-0.102750786,-0.10553515,-0.014129796,0.07883606,-4.6809557e-08,-0.0040442585,-0.06372951,0.07436273,-0.10133739,-0.0446918,-0.0557317,0.024256682,-0.0070080105,0.025677923,-0.040344197,0.04977363,-0.008885496,-0.0024272709,0.013202463,0.0649087,-0.052107092,0.088753566,0.06747084,-0.02696936,0.015946982,-0.052508276,-0.05102482,-0.086403884,0.032954667,0.0028414687,-0.019518116,-0.024279865,0.010690452,-0.06263851,-0.007462477,0.047834493,0.009614164,0.0048505478,0.03537059,-0.04346981,-0.023155332,-0.008719293,0.023329392,-0.13938119,-0.026298855,-0.046505164,-0.099556215,0.069321506,-0.031984907,-0.044782944,0.027534079,0.011483473,0.024450691,-0.00868745,-0.040809352,-0.04680831,-0.07850873,-0.050257295,-0.10173171,-0.08274864,-0.07223211,0.0006733674,-0.11077666,-0.023929724,-0.040984683,0.06685578,0.099305965,0.13261421,-0.06327724 +3.1.13.5,"Requires divalent cations for activity (Mg2+, Mn2+ or Co2+). Alteration of the 3'-terminal base has no effect on the rate of hydrolysis whereas modification of the 3'-terminal sugar has a major effect. tRNA terminating with a 3'-phosphate is completely inactive [3]. This enzyme can convert a tRNA precursor into a mature tRNA [2].",384,1.0,-0.027685985,-0.1250053,-0.08652107,-0.06282602,-0.015671005,-0.110507384,-0.016045129,-0.0042992644,-0.040335145,0.040502287,0.045773644,0.007779634,-0.041643247,0.0028868823,-0.0073243803,0.0050248937,-0.077770665,0.0037750849,0.052884523,0.025438264,0.0896526,0.058032952,-0.033278953,0.033960998,0.03137278,0.006860595,0.063055694,-0.061705645,0.02175295,-0.044479206,-0.10892403,0.02623529,0.04928588,-0.08495318,-0.016621254,0.07514708,-0.13805136,0.021163642,0.04960796,0.016215723,0.05443411,-0.019422265,0.07457112,-0.049671654,-0.038691938,-0.097963266,0.03795337,-0.044238266,-0.056009185,0.05666993,0.012451818,-0.05693961,-0.0427585,0.06322987,-0.011654426,0.042668387,-0.09203274,0.04428576,-0.029213648,0.015425207,-0.004637674,0.044981927,-0.015505013,-0.08271715,0.13950142,-0.07446098,0.041541774,-0.07051685,0.03767629,-0.018165091,-0.011938855,-0.026923368,-0.018283444,-0.004675145,-0.06281832,0.0059642405,0.08186956,-0.011129297,0.004610787,0.045725502,-0.0029604004,-0.038204875,0.047917716,0.049238127,-0.021173568,0.009163183,-0.03139405,0.052141428,0.0016507357,0.10310991,0.06978189,0.09004521,0.0291059,0.017204588,-0.068275124,0.051429804,-0.007593613,-0.002976222,0.060559392,-0.012051636,-0.016038865,0.07457264,-0.053493686,-0.027628269,-0.021777088,0.020185601,0.027006205,0.048931386,-0.005339931,0.07698289,0.040329877,0.017935732,0.048179857,0.014892607,-0.027392408,0.08109862,0.00072060985,-0.07311498,0.042580817,-0.004948057,-0.0097713405,0.026146026,0.051649313,0.0124042975,-0.034053415,0.049436245,-0.030297415,1.7783233e-33,-0.018513873,-0.031119585,0.0044239755,-0.025499007,0.026110452,0.041221444,-0.09178941,-0.03469459,-0.0493648,-0.02957761,-0.09366688,-0.004459133,0.00018516585,-0.036962602,-0.012362893,-0.057968255,-0.0038386448,0.04071347,0.068161435,0.024292534,-0.01108311,0.07582149,-0.07207959,0.040881902,0.06390299,0.036406387,0.0431512,0.0074068494,0.0147786895,-0.027456582,0.06264603,-0.053006295,-0.030205755,-0.008736561,0.091187485,-0.0486258,-0.040911477,0.019674353,-0.097113706,0.047653034,0.02006884,0.017898137,0.009575467,0.006660729,6.721996e-05,-0.031274,-0.0026178907,0.02179456,-0.037052173,0.019905156,0.049178362,0.036104023,0.02486971,0.04979355,-0.033417013,0.0021909452,0.017143497,-0.00063339714,0.12314492,0.02643031,-0.04026726,0.027362697,0.021300795,0.058271434,-0.0199793,0.031866163,-0.072963804,-0.052373018,0.027234552,0.034781154,-0.077988766,-0.054304823,0.06336221,0.010600175,0.009331298,-0.023957951,-0.04289439,-0.0058630845,-0.05871536,-0.013983141,-0.002550332,-0.016915329,0.058552872,-0.010154579,-0.03605217,-0.008666216,0.0041717608,-0.07911549,-0.0015376084,0.06346571,0.022034543,0.033028506,-0.08924675,0.020259801,0.05888586,-3.0449254e-33,0.07603462,-0.061010744,0.027540727,-0.07590554,-0.107467875,0.03484251,0.02048758,-0.14731568,0.0042165294,-0.08691486,0.07957611,0.06983556,-0.08173893,-0.0384007,0.052141946,-0.031030737,0.008212482,0.020209633,-0.044114307,-0.06904859,0.056585327,0.09727993,-0.06965115,0.009735334,0.02531631,-0.04428608,0.017288899,0.0795942,0.034732625,0.05235626,-0.0022130639,-0.00054307684,0.064215116,0.06014689,-0.080505565,0.04432544,-0.029178169,0.0045340527,0.054298364,0.03524602,0.026530752,-0.006995113,0.03554968,0.058056172,-0.031021256,0.045226533,0.008406843,-0.01451596,-0.024856603,-0.04098787,0.09296965,-0.0068085687,-0.010508563,-0.035987113,0.11850906,-0.018589603,0.00029591736,-0.05270512,0.0290501,-0.04265383,0.014381156,-0.05107741,0.032719303,-0.09398436,-0.0052235657,0.022026628,-0.02619921,0.059449516,0.028072964,0.030656202,-0.032463294,0.007765087,0.03217952,0.03318731,0.007954731,-0.020375688,-0.058110286,0.0042846724,0.013866279,-0.124517724,-0.06523355,0.031051064,0.037701968,-0.09203376,0.034808923,-0.09355424,0.0072295484,0.104183145,-0.0059606344,0.06996033,-0.011012448,-0.015234157,-0.02623362,-0.04095248,0.02373998,-3.9696552e-08,-0.062689714,-0.04177826,-0.024807481,0.044964816,0.0045753494,0.112605795,0.0070998874,0.049844127,0.09012741,0.0015541329,-0.03674462,0.016305244,0.0051839654,0.037835684,0.060298797,0.0154706985,-0.06455687,-0.025016107,-0.050187197,-0.04278762,-0.15752333,0.030334271,-0.17176437,0.013951298,-0.037545394,0.009072398,-0.0265028,0.07715406,-0.058768936,-0.026110519,0.05554056,0.029789032,0.046706155,-0.002833342,-0.042993102,0.01926754,0.012107534,-0.03989031,-0.05514902,0.05123364,-0.02050152,-0.05700241,-0.05838281,-0.0033815952,-0.11574005,-0.0161794,-0.035544172,0.0791438,-0.03519341,0.030765165,0.081609786,-0.0025188788,-0.010200552,-0.01776776,0.05251552,0.0028615443,0.0037301537,-0.051011425,-0.09952643,0.024241505,0.055012904,-0.03390044,0.11506853,-0.08787135 +3.2.1.155,"The enzyme removes branched oligosaccharides, containing preferentially four glucoside residues in the main chain, from xyloglucan molecules in a processive manner after the initial endo-type attack on a polysaccharide [1-5]. Hydrolysis occurs at either the unsubstituted D-glucopyranose residue in the main backbone and/or the D-glucopyranose residue bearing a xylosyl group [1-5]. The enzyme does not display activity, or shows very low activity, towards other beta-D-glucans [1,2,4,5].",384,1.0,-0.020836543,-0.049517732,-0.01293436,0.015079522,0.06728157,-0.066187926,-0.009364895,3.146519e-05,0.07661756,0.01936396,-0.012141066,0.107694864,-0.040524464,0.05385011,-0.113713145,0.022254024,0.010925993,-0.026695363,-0.014789282,0.0058485004,0.10981781,-0.022298321,-0.019684529,0.04475325,0.08453189,-0.057335217,-0.0032189665,-0.05329468,-0.06275903,-0.0533132,-0.017326495,-0.052191142,0.07545994,-0.008918139,0.039618578,0.08135437,0.0082765715,-0.013168621,0.022136526,-0.02626583,0.03880152,-0.032714102,-0.012458962,-0.0053150533,-0.076026276,-0.045226254,-0.08710271,0.045802444,0.016690806,0.055500228,0.01929488,-0.11656748,-0.06925588,0.04051708,0.037752558,-0.02252646,-0.05705283,-0.027155505,0.022647554,0.069654524,0.06154114,0.07704408,-0.045092385,0.034517176,-0.034095824,-0.09953333,0.024801996,-0.04260436,-0.005568988,0.01671846,-0.02611668,-0.02366195,0.023238266,-0.036366727,0.064687185,-0.045661367,-0.01601954,-0.06855417,0.05579568,-0.026923578,0.06738504,0.021739854,0.072648376,0.059116513,-0.04635301,0.008023882,0.0015298154,0.0039633214,0.0646316,-0.017645245,0.023464188,-0.03384124,-0.04679716,-0.018920172,0.0046787225,-0.06754393,0.04540904,-0.0038381084,0.011912338,-0.01877632,0.012016151,-0.033841215,0.064123705,-0.093107045,-0.07984368,0.030168643,0.007420227,0.088197395,0.056908466,-0.028553205,-0.049700405,0.010751413,0.01909037,0.051238276,-0.080226466,0.0715858,0.095028125,-0.057595834,-0.105664134,-0.0073828097,0.029852081,-0.05234235,0.098435916,0.049983367,-0.0786959,0.06661642,-0.009187762,1.7582855e-33,-0.0053742137,-0.024365166,0.006295567,-0.03177519,0.032442473,-0.020178689,-0.029992305,-0.019405076,-0.022203704,0.082985826,-0.07032306,-0.03157781,0.0020231088,0.127737,-0.017540772,0.052429207,0.03345207,-0.021191359,0.037362207,0.0189037,0.032117754,0.0746413,-0.0544768,-0.0034757687,0.051318135,0.069601595,-0.07607734,0.05788068,0.08252544,0.004421327,0.006071267,-0.036581237,-0.08566531,0.07697115,0.01394736,0.10349345,-0.032239053,-0.05641574,0.05358906,-0.01493692,0.026658487,-0.00300146,-0.032653913,-0.08038513,0.034427017,-0.034892246,-0.012981511,0.036740936,-0.04165207,0.0689239,0.059302386,-0.005302388,0.023485942,0.07744861,-0.05790327,0.036668885,0.0014897896,-0.029467909,0.023774663,0.051720716,0.03701254,0.03462048,-0.030619472,-0.07216268,-0.01041574,-0.03752103,-0.032101266,-0.0013657602,-0.07947036,0.010388879,-0.10036737,-0.022859178,0.012509259,0.03447718,0.0021279296,-0.033150204,-0.014623045,0.033233255,0.042438794,0.013893174,0.05784868,-0.0017700956,0.02819074,-0.0024807812,-0.079331085,0.0718057,0.0039238897,-0.053082634,-0.051587574,0.09704437,-0.04120694,-0.04722602,-0.10265895,0.090103045,0.035947993,-4.505098e-33,0.08615487,-0.10300366,0.07288517,-0.052854735,-0.043483913,0.0106197735,0.03248052,-0.03907636,0.033632636,-0.07979108,0.043389678,-0.0014401523,-0.05452478,0.0072145048,0.026322212,-0.0019984154,-0.06161587,0.04690032,-0.079094455,0.010078501,-0.053652067,0.077406995,0.07015384,-0.056379188,0.050066076,-0.03417295,0.054536298,0.021711461,0.043181323,0.03224348,-0.007035057,-0.00887466,0.018853482,-0.035466567,-0.020156432,0.054531943,-0.12296617,-0.005201551,0.04312624,0.0035183155,0.021270037,0.052407626,0.007372184,0.0073808194,0.03677155,0.10169912,-0.043004576,0.049262196,0.0033223797,-0.06952358,0.037450098,0.010753331,-0.016475253,0.08130936,0.049303416,0.07296797,0.04562151,0.018746475,-0.052670892,-0.08147168,-0.056367394,0.023309091,0.006555305,-0.053039167,0.08637186,0.008026403,-0.0070896284,0.052181277,0.010838108,-0.00070208276,0.024114076,-0.039449446,-0.06977857,-0.012885286,-0.039585058,-0.022778744,-0.15912487,-0.06115477,-0.024202526,-0.03103786,-0.01745144,0.030917551,0.028398657,-0.078042716,0.0508795,-0.05659741,0.0049226936,0.12802224,0.03051842,0.03596921,0.010612692,-0.0068211807,0.0016346114,0.03352048,0.08124096,-3.9892807e-08,-0.0032945536,-0.00784186,-0.00467059,-0.08569238,-0.048213545,-0.025821924,0.029490573,0.05175696,-0.019894892,0.03129399,0.0020155,0.09320574,-0.0560877,0.009752345,-0.045530275,-0.007457068,0.014064813,0.023207968,0.010572843,-0.036069155,-0.123725876,-0.022697859,-0.08717087,-0.00850821,-0.04490342,-0.112013705,0.075064726,0.06877715,-0.050128937,-0.022338243,-0.009899934,0.0820301,-0.0768066,-0.06588616,-0.0006168141,0.10891802,-0.096100025,0.0033689819,0.029742308,0.02075516,0.024594847,-0.006928111,-0.0048214355,-0.0027052716,-0.051135458,-0.008884996,-0.0020979748,-0.00091217377,-0.010503701,0.0779883,0.020052934,-0.0041766944,-0.08110657,-0.06156128,-0.055690773,-0.0021940765,-0.011373494,-0.03639165,-0.009046941,-0.08078082,0.02271836,-0.06397697,0.1274311,-0.051767 +3.2.1.157," The main products of hydrolysis are iota-neocarratetraose sulfate and iota-neocarrahexaose sulfate. iota-Neocarraoctaose is the shortest substrate oligomer that can be cleaved. Unlike EC 3.2.1.81, beta-agarase and EC 3.2.1.83, kappa-carrageenase, this enzyme proceeds with inversion of the anomeric configuration. iota-Carrageenan differs from kappa-carrageenan by possessing a sulfo group on O-2 of the 3,6-anhydro-D-galactose residues, in addition to that present in the kappa-compound on O-4 of the D-galactose residues.",384,1.0,-0.003821028,-0.09107871,-0.011859961,-4.3005442e-05,0.08108249,-0.0038673526,-0.02926315,0.040374167,0.09066397,-0.051549807,0.010400939,0.010100551,-0.11981981,0.06730253,-0.102374315,0.047498338,-0.02129601,0.021943355,0.0071980464,0.025670003,0.14805472,-0.009658657,-0.0063257334,0.014959871,-0.016823027,-0.009403889,0.023168255,-0.07837616,-0.046339452,-0.095979914,0.044627883,-0.050610714,0.10029032,-0.03154805,0.058793552,0.01982699,0.0019910226,-0.069235526,-0.02736288,0.0070104743,0.048386846,-0.029793799,0.009321869,-0.03473874,0.03642186,-0.07510681,-0.04377841,-0.018066153,-0.011257366,0.010406355,-0.03539618,-0.09909751,-0.1058875,-0.015464048,0.044713933,0.009270451,-0.07032935,-0.058871534,-0.00049147353,0.056476265,0.11506508,0.08127327,0.0044457843,-0.01828109,-0.04109457,-0.027432814,0.108186156,-0.06510758,-0.093849555,0.025668753,-0.08942772,-0.057789568,-0.021699874,0.040632907,0.045644753,0.042904183,0.048264377,-0.06796705,0.013302454,-0.021073312,-0.037660427,0.013633698,-0.03600428,0.031530794,-0.029650703,0.020559663,0.01564333,0.03827649,0.049999163,0.022036968,0.018889396,0.023526339,-0.022312716,-0.047319256,0.05755634,-0.035287492,0.017651204,0.031449772,0.025797682,-0.03221647,-0.035805337,0.0479639,-0.029683854,-0.09373825,-0.10298775,0.069517404,0.013086631,0.06662372,0.07161883,0.06308665,-0.0086194975,0.011545973,0.023038879,-0.05329383,-0.0708247,0.12250557,-0.014932881,-0.05602743,-0.041732423,0.048916087,-0.029861491,-0.038543083,0.04309131,0.12054322,-0.010210726,0.12055401,-0.041433904,2.2635688e-33,0.10937881,0.024582539,0.02054244,-0.063222945,-0.003667146,-0.040627956,-0.06537143,-0.034204576,-0.044197742,-0.003882466,-0.08309444,0.027617315,-0.019574659,0.0047749905,0.025383536,-0.013406206,0.062461726,-0.004541909,0.007834722,-0.021232156,-0.017098116,0.03820698,-0.08507799,0.0043337955,0.07832332,0.0070069428,0.009418018,0.011488209,0.07868114,-0.003553984,0.087833025,-0.12595078,-0.03931331,0.024595644,0.037675638,-0.0028893126,-0.005104284,-0.03027333,0.015661107,0.032284666,-0.014569278,0.03955088,0.052612856,-0.013462832,0.022693986,-0.084857,-0.017288348,0.0931604,0.049692158,0.016330821,-0.023283135,-0.0058020726,0.013575279,0.03953048,-0.02305537,0.005867378,-0.09839407,-0.015764916,0.04451962,0.018620813,-0.015978066,0.024065811,-0.016178343,-0.03807017,-0.009037472,0.051857788,-0.03004163,0.053152163,0.018377846,-0.021960199,-0.08974608,-0.003207332,0.06296826,0.0065768855,0.053797238,-0.03733034,-0.034145303,0.048370253,-0.026826425,0.0059626917,-0.030639336,0.05645874,-0.0069462406,-0.03251628,-0.04439657,0.0606626,-0.0076319724,0.022239598,0.02664654,0.090046085,-0.017827766,-0.051101964,-0.07521281,0.041749123,-0.0133943325,-2.6970028e-33,0.05586251,-0.15333913,-0.022419147,-0.046362657,-0.05060778,0.035789784,0.016508155,-0.014933667,-0.023489835,-0.10244556,-0.039745662,0.045374822,0.015511799,-0.13610199,-0.02222334,0.006470094,0.01541443,0.060894087,0.017677398,-0.0064453515,-0.021420281,0.08319832,0.04969792,-0.000253467,0.054216973,0.019452749,0.02496635,0.031806022,-0.0027899486,0.034529988,0.05091845,-0.012760833,-0.0057610166,-0.066426784,-0.08522116,0.059296586,-0.09185195,0.009690345,0.010198109,0.062354267,-0.040551327,-0.031816754,-0.008176283,0.034581237,0.0073214513,0.07599607,-0.03634095,0.018591095,0.0501746,-0.020408172,0.019216625,-0.0081716245,0.026306704,0.035153024,0.04654311,0.07982562,0.060489584,0.02131095,-0.017480053,-0.023151722,0.037709735,-0.035882667,0.071447514,-0.08011263,0.05988474,0.11030903,-0.025991017,0.059382193,0.03624143,-0.03424306,-0.054598033,-0.049605917,-0.016971802,0.051882364,0.018518211,-0.030959835,-0.0814803,-0.024165709,-0.044002865,-0.021339433,-0.01547041,0.037599433,0.012698668,-0.10516416,-0.041754764,-0.029997943,0.086957805,0.10239993,0.025286404,0.035691887,-0.05207891,-0.0017257531,-0.046513937,0.04856678,-0.0061996845,-4.4566836e-08,0.023389596,-0.053579252,0.084142044,-0.0020851495,-0.04794452,0.019390069,0.08938997,0.06824776,-0.008973748,-0.01271883,-0.017175646,0.10035428,-0.034164198,0.0014068546,0.08537963,-0.049222585,0.01804184,0.0062807137,-0.015922084,-0.018010616,-0.107104875,0.009579674,-0.07363357,-0.011738623,-0.06036811,-0.042773463,0.058483247,0.008582817,-0.051929068,0.04435444,0.0056897188,0.06984365,-0.022956306,-0.02164963,-0.057657205,0.031823996,-0.061867297,-0.015027912,-0.027862223,0.05129947,0.017731853,-0.05255512,-0.01935388,0.018294465,0.02575751,0.006698245,0.0061660246,0.010995324,0.016090034,0.05267367,0.05548707,-0.073067024,-0.08216164,-0.05464592,-0.04995215,-0.03972066,0.06638722,-0.079031944,0.015923312,-0.0048173885,0.025799643,-0.06598336,0.19343549,-0.033663616 +3.2.1.158,"Requires Ca2+. The enzyme from Thalassomonas sp. can use agarose, agarohexaose and neoagarohexaose as substrate. The products of agarohexaose hydrolysis are dimers and tetramers, with agarotetraose being the predominant product, whereas hydrolysis of neoagarohexaose gives rise to two types of trimer. While the enzyme can also hydrolyse the highly sulfated agarose porphyran very efficiently, it cannot hydrolyse the related compounds kappa-carrageenan (see EC 3.2.1.83) and iota-carrageenan (see EC 3.2.1.157) [2]. See also EC 3.2.1.81, beta-agarase.",384,1.0,-0.0451382,-0.050655726,-0.06991067,-0.0024012376,0.012093562,-0.026833013,-0.026885994,0.08345205,0.079641044,-0.059978012,0.007594923,6.874494e-05,-0.15304416,0.041901655,-0.05407026,-0.0029517876,-0.019831987,0.0619972,-0.054593094,-0.014357819,0.18065529,0.01058981,-0.071060166,0.027403304,0.028469473,-0.051881906,-0.016119087,-0.08337586,-0.04084806,-0.051227,0.052210394,-0.046673607,0.082641885,-0.06339666,0.04308966,0.07056235,-0.041870013,-0.049256418,0.04682343,-0.037096716,0.05539584,-0.030524006,-0.0013187085,-0.05623631,0.005013432,-0.05806388,0.01302597,0.02410413,-0.034769297,0.0070011406,-0.09168022,-0.07436524,-0.09216114,-0.00192744,0.0067387144,-0.044649728,-0.046346445,-0.048341032,-0.044048015,0.039171696,0.059635792,0.024069421,-0.02811875,-0.044227183,-0.029843751,-0.044799842,0.084275655,-0.03592749,-0.019999404,0.024895756,-0.028213702,-0.019750258,0.012227115,0.05541553,-0.040010013,0.0112124,0.0276493,-0.020737898,0.031657346,-0.008188544,0.024782555,0.0074106427,-0.0071042944,0.060753956,0.0072010886,0.047828924,-0.041686818,0.079104565,0.057687894,0.035772476,0.054014355,0.11016891,0.023711568,-0.056165855,0.0021055054,0.026373591,-0.00020220458,-0.015706806,-0.016454928,-0.020945976,-0.005153084,-0.008089608,-0.01939206,-0.12022259,-0.107574984,0.092342235,0.019533401,0.04407672,0.071747206,0.04039428,-0.034393538,0.01736544,-0.010051045,0.017153991,-0.10260299,0.069530584,0.0022270435,-0.07919416,-0.008203831,0.025172893,-0.056572028,-0.05981215,0.050094686,0.077068195,0.06517278,0.021177417,-0.052916273,5.7888024e-33,0.05158137,0.013405509,-0.0056235697,-0.08454387,0.05867818,-0.050782938,-0.043514576,-0.026487393,-0.022717174,0.0064160125,-0.067609385,-0.03453373,-0.05883658,-0.01589202,0.008725824,0.04564088,0.027446505,-0.018336525,0.024470815,0.040914655,0.03615228,0.038612314,-0.07197635,0.02190524,0.061933234,0.0160402,0.024377128,-0.020134756,0.027660985,0.003676127,0.06346759,-0.105109364,-0.07421583,0.02983907,0.09177224,0.007910873,-0.048451465,0.016644605,-0.04680391,0.08349322,0.013005534,0.048767526,0.054917857,0.017665008,0.043172367,-0.052741263,-0.026491992,0.14432523,0.03427742,0.07759431,0.014153411,-0.009007617,0.044019975,0.047930945,-0.04964705,-0.020923892,-0.059140027,0.028604498,0.03937217,0.014647262,-0.015894327,0.0026599765,-0.001980106,-0.071087725,-0.050424684,0.022617914,-0.034642026,0.062467568,0.0310815,0.008533142,-0.048537634,0.0054244404,0.030126307,0.047083717,0.033863764,-0.07150413,-0.0072471546,0.015057259,0.0108628515,0.019650776,0.014548441,0.0058167917,0.04268597,-0.0021579661,-0.10428638,0.06268678,0.0030908547,0.07906942,0.034318857,0.03861654,0.03780644,-0.09535257,-0.07369821,0.04678126,0.0040259147,-5.0291696e-33,0.100049034,-0.11534005,0.023879854,-0.055237845,-0.05783546,0.031928,-0.02110226,-0.01260292,-0.020653667,-0.078506865,0.01905708,0.069230095,0.01885881,-0.04801243,-0.045095265,-0.0044711297,0.044382297,0.00271883,-0.012792707,-0.061599463,-0.047138095,0.12512828,0.026314264,0.010486297,0.044010796,-0.024536522,-0.010123084,0.099680856,0.03129118,0.050543655,0.0149559,-0.03513863,-0.006914959,-0.12440885,-0.09106293,0.014836911,-0.032933615,0.011179109,-0.0062530497,0.060346585,0.0352954,-0.068252176,0.013454967,0.077612504,0.0055970177,0.07220965,-0.03284634,-0.014083637,-0.0149325365,0.0033584046,0.0734347,-0.0013129389,-0.0011696746,0.05693861,0.08418948,0.02752689,0.060373276,0.03452257,-0.10719389,-0.011355063,-0.0042530615,-0.053275853,0.057070468,-0.046305932,0.0655002,0.1168278,-0.037427966,0.08889478,-0.011343894,0.036603134,-0.014008394,0.01514562,-0.021630796,0.018158777,-0.0029667527,-0.0142476605,-0.08103143,-0.037579387,-0.0106398435,-0.064185575,-0.016909525,-0.005996798,-0.012838522,-0.09618931,-0.0041573704,-0.0021846045,0.06042492,0.094136104,-0.019466948,0.032993272,-0.03316801,-0.030580342,-0.00041665905,0.09026064,-0.005342223,-4.8934105e-08,-0.031119142,-0.0026789068,-0.0058869347,-0.021522548,-0.038100865,0.05632545,0.05525565,0.07657676,0.017562248,-0.024517134,-0.09237145,0.061767187,-0.006012726,0.020867404,0.08175912,-0.08414857,0.029707491,0.012911941,-0.030917538,-0.067824885,-0.060433615,-0.010246916,-0.1257126,0.0023359023,-0.032986157,-0.009938046,0.048389085,-0.009990168,0.031317927,0.010585104,-0.04393796,0.05841667,0.022746364,-0.03833467,-0.03593884,0.03474038,-0.025287824,-0.04501488,-0.0073835626,-0.026363283,0.029004794,-0.036047023,-0.05005518,0.015458005,0.022167813,-0.018168565,0.0517101,0.0117500285,0.044701405,0.03469953,0.10824948,-0.010860852,-0.09202721,-0.034978606,-0.080028854,-0.025250623,0.058950163,-0.055564906,-0.050317205,0.0039372784,0.095482096,-0.100889996,0.15315512,-0.019730195 +3.2.1.159,"When neoagarohexaose is used as a substrate, the oligosaccharide is cleaved at the non-reducing end to produce 3,6-anhydro-L-galactose and agaropentaose, which is further hydrolysed to agarobiose and agarotriose. With neoagarotetraose as substrate, the products are predominantly agarotriose and 3,6-anhydro-L-galactose. In Vibrio sp. the actions of EC 3.2.1.81, beta-agarase and EC 3.2.1.159 can be used to degrade agarose to 3,6-anhydro-L-galactose and D-galactose.",384,1.0,-0.0064710844,-0.09874291,-0.013363837,0.034218837,0.00024624122,0.0102687655,-0.025315132,0.044755038,0.042277638,-0.022334216,-0.008108054,0.010120293,-0.12192149,-0.0147880735,-0.052498862,-0.02502806,0.07295351,0.067955226,-0.048301846,0.04990861,0.161537,-0.06163392,-0.017447801,-0.007737852,0.06580686,-0.06590766,-0.044427797,-0.074845746,-0.024994582,-0.077133775,-0.0051859394,-0.040807385,0.080693856,-0.02348126,0.013105772,0.0208005,-0.050119933,-0.09115559,0.01181598,-0.062187213,0.069697976,0.0024140265,0.004943497,-0.068235174,-0.023265257,-0.0034674448,-0.081855446,-0.0024679857,0.028962452,-0.08572479,-0.021156257,-0.1192347,-0.086797275,-0.009083203,0.0047619655,-0.009778784,0.008340509,-0.09632707,-0.0049879136,0.088289656,0.06680521,0.07999818,-0.05652359,-0.005919224,-0.06314188,-0.05219137,0.06685912,-0.041552678,-0.051631454,0.099780895,-0.08046001,-0.018236872,0.03240194,-0.0033241054,0.048355002,0.08707825,0.039790694,-0.046400137,-0.0017814067,-0.035538375,0.054689135,0.037344426,0.03310633,0.032251883,-0.026675398,0.0025537626,0.027958823,0.011359276,0.04515388,0.018545039,0.006249629,0.064100794,0.017479286,-0.0479718,-0.028839849,-0.006213165,0.017129064,-0.057581,0.0585772,-0.035426572,-0.0065926025,0.03457003,-0.015866987,-0.086024195,-0.07558343,0.096838534,-0.040262673,0.09101259,0.05463276,0.07370858,-0.035831038,-0.009397328,0.017869951,0.006385698,-0.13965218,0.10339176,0.023541976,-0.04790632,-0.042162426,0.031728912,0.042168498,-0.040727094,0.108919725,0.04906323,0.021328095,0.069539085,0.025986245,1.9228296e-33,0.014136448,-0.029730614,-0.013278591,-0.03835317,0.03067815,0.034399785,-0.077305324,-0.02906345,0.015872743,-0.004234872,-0.07539641,-0.028398724,-0.0036600714,0.080920085,0.020498222,0.07416853,0.015719388,-0.019938555,0.044826847,0.01557172,-0.0059066373,0.0055482537,-0.04005071,-0.027391313,0.05020284,0.007902723,-0.04862057,0.01794086,-0.0095425155,0.0053829425,0.068063274,-0.022196209,-0.09814222,0.04838791,0.03690411,0.045200363,-0.059554905,-0.04826294,-0.0184993,0.040864877,0.055102922,0.09255624,-0.0008220408,0.005191232,0.07641671,-0.06847864,-0.0015125669,0.099014,0.053266264,0.03567505,0.0146258995,-0.0058494876,0.039178547,0.020623721,0.0042899707,0.032519594,-0.033477925,0.034223683,0.044982128,0.015341199,0.012506582,0.055938065,-0.013209319,-0.0018995655,-0.022550851,0.050780486,-0.038126394,0.05296369,-0.084476106,-0.028241914,-0.10825359,-0.030280512,-0.0009576131,0.032017235,-0.015176639,-0.08980585,-0.014338102,0.039022934,0.029196823,-0.019450916,0.048622858,0.03414227,-0.006191322,0.004554994,-0.04902454,0.039130643,-0.014003438,0.07032003,0.003419695,0.050126694,0.050070535,-0.08283772,-0.057745453,0.05998492,-0.0062625334,-3.0253011e-33,0.06638156,-0.009419091,0.0034092844,-0.03483981,-0.037112787,-0.0073780953,0.01359951,-0.030711252,-0.020866502,-0.087031886,-0.009851015,0.06892081,0.068542995,-0.06313687,-0.038929548,0.018330695,-0.01981248,0.0051202974,-0.08010821,-0.019650972,-0.057414163,0.10086459,0.034448087,0.019540163,0.06730003,-0.06327338,0.022075087,0.059206523,-0.008265863,0.03042353,0.09167873,-0.02711719,-0.0068820626,-0.1346361,-0.03759378,0.03389658,-0.02322941,-0.035871893,0.07579705,0.075850345,0.009993396,0.06271008,0.014676258,-0.03274,0.04186443,0.113313355,-0.096456744,-0.007432279,0.045688972,-0.010568122,0.023590129,-0.06139734,-0.0028009193,0.050187137,0.037350863,0.021826895,0.11030233,0.034643535,-0.08045938,-0.017274078,-0.0032866278,0.026642352,0.10329162,-0.077354655,0.07648166,0.07450599,0.013402105,0.12765367,-0.017629147,0.01983552,-0.004461773,0.028697273,-0.06371196,-0.013962939,0.019484397,-0.020437023,-0.07336841,-0.030399762,-0.044498425,-0.009789619,0.033207726,0.046460714,0.020840766,-0.047672644,-0.047843542,-0.01423118,0.031959407,0.1139777,-0.016322115,0.015844073,-0.041045792,-0.073867455,0.012139598,0.039765645,0.075338826,-4.320685e-08,0.063341126,-0.0155644845,0.016728157,-0.052215096,-0.02996886,-0.01681679,-0.02380586,0.046219207,-0.004705147,-0.055193327,-0.08577501,0.11597168,-0.00995659,0.0056183115,-0.003705973,-0.06632764,0.012687496,0.015098357,-0.032418042,-0.00082762976,-0.08780888,-0.01792689,-0.09534798,-0.016809138,0.0066984026,-0.07641409,0.07997111,-0.020871345,-0.043095373,-0.010161165,-0.00018570351,0.0671953,-0.00181819,0.012742464,-0.09082436,0.022701394,-0.04544309,-0.012535836,-0.0016832498,0.018592741,0.079026364,-0.051302418,-0.020200012,-0.014726307,-0.044710517,0.032791395,0.013441075,-0.0038368248,-0.021914536,0.0602221,0.041499596,-0.043775532,-0.09422678,0.0039775,-0.030150797,-0.1128979,0.018123908,-0.005296874,0.004474555,-0.033898175,-0.0010376604,-0.067590006,0.14161135,-0.0021711027 +3.2.1.161,"The enzyme from the tropical tree Dalbergia nigrescens Kurz belongs in glycosyl hydrolase family 1. The enzyme removes disaccharides from the natural substrates dalpatein 7-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside and 7-hydroxy-2',4',5',6-tetramethoxy-7-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside (dalnigrein 7-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside) although it can also remove a single glucose residue from isoflavonoid 7-O-glucosides [2]. Daidzin and genistin are also substrates.",384,1.0,-0.07729379,0.005744704,-0.04318499,0.03598938,0.026932001,0.025088308,-0.050173707,-0.005354982,0.06323492,-0.0083966805,-0.0049482333,0.057910733,-0.10427657,0.0061807446,-0.12115237,-0.020072976,0.03203907,0.011760046,0.006440743,-0.05596208,0.05507399,0.003789461,-0.01765694,-0.0106329,0.063848495,-0.07319484,-0.01309136,-0.015539731,-0.0010523478,-0.08165153,-0.04080587,-0.0072176135,0.03245015,0.057702616,0.0034631905,0.056011908,0.020791655,-0.053425528,0.017534768,0.01846256,0.045826,0.00038386584,-0.021693174,-0.048003167,-0.013169555,-0.038488615,-0.10885568,0.051435303,0.08229547,0.01178726,-0.039031427,-0.05488434,-0.06699966,0.04941231,0.059713718,-0.0831907,0.026832633,0.0036220544,-0.031030696,0.07637322,0.019790761,0.016739674,-0.02869884,0.0026750609,-0.12026836,-0.046253365,-0.0045567583,-0.00814566,-0.029723227,-0.03906833,-0.012515773,-0.016552504,-0.016865032,0.013556243,0.0013855235,0.037437614,-0.038062416,-0.02332819,-0.015774235,-0.02579989,0.05472206,0.08410433,0.08704575,0.06685683,-0.051792677,-0.016240204,-0.04316894,0.07734245,0.041795593,-0.030746398,0.07637438,-0.027464092,0.003554326,-0.0023660772,-0.0127380155,-0.01987898,0.04156281,-0.07462025,-0.032511204,0.01919583,-0.027783126,-0.025486538,0.046619326,-0.093786426,-0.11362508,0.13381696,-0.00034042567,0.02994638,0.107799046,-0.031595938,-0.08417889,0.08990982,-0.012904581,0.06378065,-0.11577399,-0.04578929,0.04599135,-0.026452452,-0.00025120203,0.017807074,-0.008959836,-0.050438505,0.07700742,0.04455002,-0.03420754,0.09104182,-0.020397263,1.555142e-33,0.08064827,-0.028939907,0.019517584,-0.056382444,0.037083216,-0.042079955,-0.01881762,-0.005140985,-0.024004629,0.033542737,-0.1213911,-0.029448211,-0.046309743,0.066054426,0.056904417,0.08344609,0.025438001,-0.053736,0.092657164,0.03171053,0.02288527,0.06810876,-0.07929139,-0.030116634,0.06592501,0.086578704,-0.038579583,0.011327525,0.023607116,0.0017405417,-0.024072494,-0.07055313,-0.0782638,0.0114357965,0.0055386825,0.033732284,-0.040248685,-0.048155427,0.009774894,0.04849979,0.029533554,-0.0017886682,-0.02344629,-0.024438277,0.051235244,-0.0032923392,-0.010362417,0.04358651,0.026602285,0.113883555,0.032099597,-0.010805011,0.05464729,0.06398681,-0.043728046,0.08092356,0.009849481,-0.016445277,0.07433159,0.051481668,0.066066094,-0.034158185,0.023469906,-0.028679112,0.030971682,0.0004907804,-0.08744375,0.0069641103,-0.07220116,0.0083391415,-0.076381825,-0.065027244,-0.01958689,0.051739253,0.055660013,-0.109788455,0.045594018,-0.007906969,0.015365792,0.015231858,0.07147444,0.03785296,0.026678,-0.053010743,-0.049707048,0.03742963,-0.04186017,-0.005870528,-0.070674986,-0.011959624,0.0001975542,0.015676115,-0.080325596,0.02575025,0.021893457,-3.4881616e-33,0.10676721,-0.12667829,0.09046219,-0.08762976,-0.062308177,0.020760627,-0.0021670803,-0.06251457,-0.030821128,-0.044529457,0.011778024,-0.014761473,0.0009770436,-0.00955468,-0.020441515,0.013815553,-0.067614436,0.12079201,-0.09095341,-0.009161249,-0.061399892,0.08870641,0.006654883,-0.034701146,0.055923536,-0.040057115,0.047134858,0.07390113,0.013386922,0.05546218,0.0088649215,0.01817543,-0.044534113,-0.05861339,0.022107637,0.02912058,-0.09274884,-0.045782167,-0.019439142,0.03205891,-0.02178773,0.06319603,0.021173635,-0.012328047,0.085793674,0.07823321,-0.08332316,0.004991628,0.0103624035,-0.039253123,-0.003376215,0.034537423,-0.007523888,0.065326884,0.06385358,0.023223868,0.05563947,0.030723019,0.03868657,-0.06500886,0.007589765,-0.03811507,-0.0051800157,0.016159154,0.070353776,0.06686035,0.025159054,0.04507995,0.051236387,0.007868516,-0.006369298,-0.03278874,-0.0058578025,0.022510977,-0.0001242791,0.029371873,-0.11991054,-0.03033804,-0.045051977,0.030187825,-0.0045856703,-0.036217004,-0.044965312,-0.078909926,-0.013869534,-0.049572468,0.054707613,0.071360454,0.005690489,0.035018675,-0.007831352,-0.007467568,-0.0590403,0.053015668,0.034089025,-5.111859e-08,0.07994208,-0.07839496,-0.003393445,-0.06787589,-0.06443382,-0.051365044,-0.050981995,0.051185418,-0.015828397,-0.034603808,0.011466595,0.10196983,-0.05118766,0.03375996,-0.007291814,-0.0012533912,0.010262344,0.01996733,0.03544967,0.11910512,-0.080266714,0.017902816,-0.07818977,0.037083574,-0.0080176685,-0.12131432,0.060169674,0.088275746,0.05026081,0.0050555347,-0.0024629263,0.07088939,-0.013316256,-0.0832899,0.02202891,0.015323467,-0.05533236,-0.0029978987,0.05833299,-0.014095153,0.060212404,-0.047589224,-0.0067295777,-0.033501856,-0.020594459,-0.025003165,0.0744498,0.031649925,0.0030856007,0.011139216,0.03625004,0.024099436,-0.08779574,-0.057724595,-0.07689744,-0.019085053,0.0063281436,-0.0350795,-0.0074825315,-0.092047594,-0.016934916,-0.022435358,0.14258397,0.000867172 +3.3.2.9,"This is a key hepatic enzyme that catalyses the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols. The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to the corresponding trans-dihydrodiols. The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate. Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase).",384,1.0,0.014021215,-0.048410382,-0.042765226,-0.010821451,0.070950806,-0.021015309,-0.10799371,0.028960045,0.024062926,0.01708017,-0.038446262,-0.05213296,-0.032872424,0.023203796,-0.058924478,0.0714464,-0.12285311,-0.017527662,-0.00852664,-0.039633147,0.07918468,-0.017901568,0.0030997132,-0.01510592,-0.03776226,0.0042001987,0.099016495,0.04761134,-0.0125102755,-0.07109577,0.03721906,-0.071501166,0.008490709,-0.033885173,-0.06537327,0.0862162,-0.008318294,-0.022270957,-0.02074664,0.024990557,0.034475505,0.010374102,-0.03951745,-0.018410148,-0.04349437,-0.11239862,-0.024662478,-0.030879606,-0.019291304,0.020052891,-0.010652583,-0.055880457,-0.04982613,0.05418216,0.013875067,-0.008864187,-0.018289637,-0.0339579,-0.015581436,-0.0039524096,-0.010464972,-0.052378286,-0.0010558362,0.01285647,-0.061541915,-0.009065584,-0.012983715,-0.07406353,-0.05644494,-0.08110758,-0.066938795,-0.11652376,0.10170318,0.053851,-0.0573174,0.007843874,-0.036381822,0.00020217814,0.027045213,-0.0297645,-0.018250836,-0.018398602,0.008009164,0.08279851,0.048834443,0.054443073,-0.07323854,-0.029301431,0.054298077,0.034564536,-0.012129907,-0.026283862,-0.05704246,-0.028231548,0.04533192,0.04026735,0.056574542,0.01944216,0.00451308,-0.012622994,0.021520827,0.034731068,-0.08707991,-0.10101147,-0.030658957,0.085620485,0.02569119,0.1360753,0.0025321287,-0.017411392,-0.0626248,-0.07050667,0.040392645,0.014376735,-0.01692648,0.106198445,-0.019086096,-0.024842776,0.0060688807,-0.006194696,0.013760814,0.060573272,0.089239344,0.028757486,-0.009742564,0.009598915,-0.00813939,2.712332e-33,0.026838448,0.02045087,-0.029166983,-0.0037354596,0.0036167519,0.042384554,-0.08118353,0.076120734,0.027367303,-0.04461943,-0.06278464,0.024868142,0.023880513,-0.02466532,0.002902088,-0.04358454,0.019026706,0.03755228,0.023762647,-0.017410865,-0.010823247,-0.015834989,-0.055410918,0.03406023,-0.034515996,0.071786284,-0.046258707,-0.010686053,0.05889929,0.006543863,-0.016443372,-0.071873076,-0.0287586,-0.0105561465,0.005117733,0.03636115,-0.051168695,0.028754387,0.0007494553,0.06452964,0.0789183,-0.06765311,-0.044707578,-0.03719146,0.0343163,-0.068789355,-0.008147421,0.1417135,0.06454155,0.0069247554,0.06981885,-0.044544335,0.07459611,-0.017667728,-0.07759106,0.026682276,-0.037677053,0.004621433,0.092470124,0.02441854,-0.040057354,0.07943497,-0.030978123,0.0059565865,0.032550808,0.0017852226,-0.0869554,-0.06752956,-0.08772674,0.07144256,-0.033693857,0.037893753,0.084908605,0.0025214574,0.028333284,-0.0015332074,-0.046781726,0.046908718,0.0047783437,0.024452845,-0.02423567,0.03679114,0.044076424,0.007901639,0.0007155598,0.05771677,0.0054485365,-0.06613897,-0.039999593,0.15530401,0.06460864,-0.07998686,-0.052052215,-0.017788144,0.07827762,-4.2606054e-33,0.05751654,-0.07945415,0.036147267,-0.048670847,0.025857547,0.08434235,0.015247665,-0.014863123,0.06665945,-0.08633626,0.05241457,0.03072324,0.045169372,-0.08195812,0.033528887,-0.011294879,-0.006656343,0.10318182,0.08639492,-0.063039735,0.0808457,0.0435524,-0.017869936,0.041797116,0.069969326,0.044616465,0.025372097,-0.018556297,0.056788754,0.09865034,-0.04939052,-0.0069134515,0.020788038,0.06420785,0.04603236,0.07173073,-0.14207302,-0.020481782,0.0005810812,0.03299198,-0.05967405,-0.023537822,-0.0067170137,-0.0042258687,0.056306098,0.06414011,-0.07055307,0.053598985,-0.009419584,-0.03711561,0.010991769,0.04939769,-0.10563441,0.0066430164,0.04136191,0.08647088,-0.040048823,0.0011093447,0.10019317,-0.08589533,-0.049267173,-0.02640509,0.047832254,0.05403924,-0.00893412,0.011336462,-0.0043130172,0.038000476,-0.024649242,0.011971526,0.0654346,-0.078859046,-0.034439426,0.004331267,0.03548961,0.013811352,-0.02034071,-0.07263192,-0.071337506,-0.026217809,-0.0020335638,0.035346683,0.04983664,-0.015429931,-0.025092205,-0.044645093,0.0018016394,0.11918378,0.012912748,0.06098579,0.030330341,-0.00391597,-0.082253985,-0.011654269,0.093567125,-5.4232114e-08,-0.0041049044,-0.09815957,0.06446008,0.00880628,-0.01314474,0.0045597083,0.002552794,0.007844125,0.040937092,-0.07102692,0.04716514,0.06494216,0.012985367,-0.008265988,0.028998833,-0.028516829,0.0007667502,0.021279035,-0.0151463505,-0.016101291,-0.102136426,-0.043501534,-0.015739636,-0.028107142,-0.0035191553,-0.07826968,0.002065896,0.042985383,-0.030281462,-0.024038022,0.006690018,0.007471925,-0.0053179683,-0.01411687,-0.022115981,0.05642736,0.000733203,0.05272494,-0.05409703,-0.019887498,-0.007830267,-0.10867836,-0.012752134,0.025349336,0.016530238,0.018275358,-0.0145728085,0.051715765,0.011893226,-0.036860373,-0.046802513,-0.011509203,0.048852272,-0.1057218,-0.08324595,-0.029622776,-0.016330052,-0.081894994,-0.06064149,-0.08230256,0.0033315108,0.1001458,0.19320232,-0.015872533 +3.3.2.10,"Catalyses the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism [7]. It is involved in the metabolism of arachidonic epoxides (epoxyicosatrienoic acids; EETs) and linoleic acid epoxides. The EETs, which are endogenous chemical mediators, act at the vascular, renal and cardiac levels to regulate blood pressure [4,5]. The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76, lipid-phosphate phosphatase [1,2]. Like EC 3.3.2.9, microsomal epoxide hydrolase, it is probable that the reaction involves the formation of an hydroxyalkyl---enzyme intermediate [4,6]. The enzyme can also use leukotriene A4, the substrate of EC 3.3.2.6, leukotriene-A4 hydrolase, but it forms 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid rather than leukotriene B4 as the product [9,10]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) 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+3.3.2.11,"The activity has been attributed to the microsomal antiestrogen binding site, a complex formed by EC 5.3.3.5, cholestenol Delta-isomerase, and EC 1.3.1.21, 7-dehydrocholesterol reductase [6]. Both 5,6alpha-epoxy-5alpha-cholestan-3beta-ol and 5,6beta-epoxy-5beta-cholestan-3beta-ol are substrates [3]. The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase) [3].",384,1.0,-0.035032164,-0.08707131,-0.074501984,-0.035626467,0.06481822,0.062847756,-0.07997967,-0.002943787,-0.002775847,0.030988056,0.01088656,-0.027945258,-0.06629765,-0.038690064,0.021443367,0.046577647,-0.06839342,0.00068709365,0.014031411,0.0036326835,0.029082764,-0.013444912,0.011529192,0.0027565248,-0.01573221,-0.008846562,0.064484976,0.04191666,-0.07494276,-0.057327136,-0.0043079867,-0.068118714,0.10872458,-0.034256447,-0.06350932,0.059110362,-0.07555979,-0.06436787,-0.037686467,0.024999192,0.02457959,-0.042810194,-0.051668607,-0.0312282,-0.019199569,-0.11380456,-0.02436395,-0.04265906,-0.005062899,0.012648109,0.012169076,-0.07755268,-0.047565125,0.020393012,-0.013525921,0.0072887773,-0.028967327,0.002450275,-0.015607771,-0.0064116633,0.0078165615,-0.016051026,0.009571397,0.017779985,-0.034208782,0.01317744,0.008153215,-0.04908241,-0.051615518,-0.009023565,-0.021963727,-0.063215636,0.006886608,0.06004798,0.00067561143,0.008989286,-0.051329862,-0.043553,0.020335516,-0.06064243,-0.042493552,-0.04302069,0.052344717,0.13279438,0.07623456,-0.0150096305,-0.022791445,-0.01830664,-0.0091941925,0.044419333,0.010102835,-0.0066701407,-0.05606366,0.046662223,0.03618458,0.05646033,-0.025170652,0.0072228764,0.005766497,-0.04726982,0.030620076,0.040279448,-0.100985646,-0.08212713,-0.04639729,0.027899517,0.0148155475,0.058804903,-0.05193713,-0.0030571744,-0.0031061545,-0.082904674,0.008287777,0.014340007,-0.015691038,0.04163089,0.012025762,-0.058056027,0.002178102,-0.0077945273,0.052300405,0.049056232,0.09488215,0.03815673,-0.023434954,0.044885445,0.0022597588,8.244497e-34,0.012200764,-0.0026154977,-0.02304675,0.0074433847,0.036259424,0.14212292,-0.019052893,0.045127176,0.036776803,-0.05101253,0.0015651893,0.08600216,0.06570784,-0.038398523,0.039350506,0.008256221,0.064121775,0.001872273,0.078042954,-0.031509608,0.023153659,-0.01758591,-0.05571948,-0.006436649,-0.064061,0.03792684,-0.049591057,0.031432044,0.031165123,0.013860217,-0.017979402,-0.14326823,-0.022133483,0.00070351677,0.06436601,0.003487206,-0.012456938,0.013241559,-0.01311385,0.02922412,0.08519626,-0.079997994,-0.042625368,-0.046557184,0.01098537,-0.06535469,-0.040129226,0.10131712,0.059777416,0.031698715,0.0010938941,-0.028296776,0.08660799,0.061410874,-0.044333015,0.08207171,-0.06861983,0.010428887,0.0070907352,0.055606123,-0.0470607,0.089577116,-0.003282,0.027980931,-0.014172625,0.026274046,-0.087487295,-0.06267912,-0.13365956,0.06477771,0.0027552787,0.011929069,0.108320706,-0.0059383493,0.031731375,0.05151044,-0.033449437,0.11871812,-0.059101816,0.033084497,-0.009219663,0.031838585,0.010900944,-0.0046334076,-0.024207503,0.027160212,-0.018322727,-0.03069947,0.03492432,0.07242921,0.06370578,-0.084287204,-0.07176895,0.010711251,0.037772924,-2.6830763e-33,0.06258259,-0.12988725,0.09030429,-0.08877239,0.02219216,0.11375721,0.07443785,-0.053620055,0.07121693,-0.015113417,0.04495152,0.0024940637,0.0059101745,-0.10195587,0.034735173,0.04871283,-0.027541958,0.06547992,0.040803533,-0.10529718,0.029988743,0.06256126,-0.0066634016,0.15886104,0.04187186,0.0072146654,0.05849564,-0.07060506,0.042283304,0.0813556,-0.024268977,-0.025391294,-0.027951745,0.02686355,-0.018949086,0.02895313,-0.0947682,-0.0067814896,-0.03658223,-0.006675763,-0.02656843,0.00089452293,0.0057681114,-0.043208834,0.06356549,0.104556054,-0.050642814,0.11271183,-0.026555045,0.021358462,-0.042446744,-0.012839036,-0.057425708,-0.010044177,0.03618322,0.041395925,0.013964938,-0.010679689,0.1186435,-0.03747801,-0.007908994,-0.0074182237,-0.0065876707,0.07147708,-0.02087782,0.019585252,0.024500292,0.040174004,0.029004617,0.039241385,0.036313225,-0.027121034,-0.042035572,-0.0044020233,0.002716301,0.039152283,-0.007952048,-0.04254056,-0.010079763,-0.016217377,0.02652274,0.03564302,-0.014546168,-0.003995841,-0.051890135,-0.013068372,-0.03428773,0.14179452,0.014975234,0.0022559091,-0.008541047,-0.02085354,-0.10198876,0.00016160942,0.08597083,-5.1478857e-08,0.052523438,-0.05819327,0.07528153,-0.06555085,-0.03743363,-0.056554,0.037264846,0.037975468,0.087216325,-0.06846998,0.023011684,0.107472666,0.030503487,-0.0013625209,-0.008130694,-0.0039197053,0.06914726,0.045551058,-0.010466497,-0.023413714,-0.028081946,-0.047821626,-0.05233707,-0.015413521,-0.014089395,-0.0744859,0.004107127,-0.004796609,-0.013592679,-0.06703139,0.025196852,0.0019142653,-0.009088181,0.02175853,-0.015983364,0.059911374,0.051836744,0.004459972,-0.08869624,0.068504766,-0.051056825,-0.10749708,0.029316343,-0.016499303,-0.010647767,0.024589757,0.013769412,0.031127797,0.042350806,-0.050485916,-0.11025259,0.01649693,0.0050794506,-0.07301844,-0.111480676,-0.011086065,-0.0048643686,-0.12039272,-0.02427545,-0.021623442,0.007835012,0.00806546,0.15413426,0.021533975 +3.4.23.49,"A product of the ompT gene of Escherichia coli, and associated with the outer membrane. Omptin shows a preference for cleavage between consecutive basic amino acids, but is capable of cleavage when P1' is a non-basic residue [5,7]. Belongs in peptidase family A26.",384,0.99999994,-0.08143023,-0.051974952,-0.04835834,-0.052592322,0.09781279,0.012792243,0.06829539,0.08413648,0.10329608,-0.022034688,0.037250597,-0.002452591,-0.113674425,0.079040945,0.008013023,0.017326443,-0.092880204,-0.0003861273,0.018291954,-0.053953517,0.050221723,0.12456771,0.02913789,-0.015423449,-0.044975743,0.02348034,0.04537084,0.003557444,0.053561084,-0.04613035,-0.026297737,-0.1103207,0.067032434,-0.0053466028,0.094438925,0.008428971,0.015984163,-0.06654406,0.06761168,-0.008595821,0.10365707,0.03204732,-0.02711214,-0.014907215,0.03478223,0.010815232,0.039830107,0.07861427,0.010560151,-0.07526464,-0.031759948,-0.052814037,0.005893962,-0.027264532,0.038993172,0.020944076,-0.04614682,-0.12602197,0.0071133706,-0.0048122043,-0.022104708,0.02169351,0.040489372,-0.023950286,0.040361706,-0.06411633,0.10872726,-0.014763618,0.006996891,0.045176074,-0.040459167,0.01422878,-0.042959303,0.092724256,0.008145168,0.050469533,-0.008569725,-0.0035104302,-0.03498342,-0.013626803,0.004455261,-0.03435335,0.004625621,0.11269777,-0.017670663,-0.0321748,0.0060377526,0.027769493,0.01360869,0.0028814615,-0.010714397,-0.09949478,0.012124923,-0.02841177,-0.02731787,0.015271889,-0.008399609,-0.10183193,0.005917412,0.042978436,-0.06715907,0.05791749,-0.010256203,7.628451e-05,-0.050063368,0.0075682197,-0.031431638,0.07310309,0.014415558,-0.039232343,-0.0151571715,-0.05330136,0.028738284,-0.025416609,-0.011009063,-0.027065825,0.040186863,0.010221711,0.033382148,0.033554535,0.012082709,-0.03543813,0.018014679,0.15812677,-0.07272208,0.0012650838,-0.11998314,1.1586751e-33,-0.0010592833,-0.016746724,0.022501888,0.0131297335,-0.023821857,0.023978755,-0.032485634,-0.06976277,-0.009565106,-0.034090824,-0.09197712,-0.16502693,9.2258495e-05,0.012796244,0.023000136,0.0028072423,-0.058691222,0.03437051,0.073695555,-0.035133064,-0.03343075,0.081216685,-0.0018494597,-0.036520723,0.06858548,0.017899921,-0.027480619,0.008821932,0.0011117988,0.0019714192,-0.0031797155,0.0010035121,-0.06108381,0.02643713,-0.031251527,-0.030487604,-0.015794657,-0.10160134,0.056710947,0.10225489,-0.054650415,0.041578505,-0.027855374,-0.021948123,0.10300461,-0.05683878,-0.0188169,0.076727316,-0.030161213,0.06363657,-0.004604091,-0.040608358,0.027178783,-0.071830936,-0.08807539,-0.08704244,-0.020598095,0.02186855,0.053489067,0.06101434,0.04379674,0.046043687,-0.110139556,0.0427239,-0.045500025,0.0082988525,0.01596636,-0.016076865,0.05173199,0.10750879,-0.026174437,-0.011901407,0.017846495,0.02104935,0.0032872243,-0.04940413,-0.083996944,0.0953646,0.06112801,0.06455644,-0.0068310834,-0.0041799084,0.0022147798,-0.016629906,-0.05516897,0.0642249,0.01293629,-0.06179612,-0.048019495,0.061170105,0.06778334,-0.04174623,-0.029425856,0.028528126,-0.018128937,-2.443547e-33,0.018095193,-0.083060935,0.060007263,-0.050205067,-0.10831265,0.029401997,-0.05112947,-0.013417831,-0.026389994,-0.035987288,0.027997639,-0.037987202,0.023880202,-0.060960934,0.042268585,-0.031952985,-0.062185537,0.06319433,-0.0119905975,0.014044669,0.031975526,-0.033079192,0.010703215,0.011038694,0.05545575,0.038494717,-0.009596859,0.09535495,0.005304423,0.0013375997,-0.091046125,0.056366496,-0.020656547,-0.043285944,-0.06213057,0.03021587,-0.019423932,0.03172302,0.02723583,-0.062668,0.0065824306,0.08234359,0.05138099,0.0133645255,-0.07194058,0.05790988,0.060752932,0.049545046,0.06293994,-0.05753969,-0.013691215,-0.01807338,0.0559077,-0.02673441,-0.02974076,-0.02585155,0.048319433,0.0057394323,0.010818919,0.010286634,0.050240494,-0.023380792,0.031539436,0.07980712,0.077952616,0.022851862,0.002391094,0.06608833,0.075954765,-0.06755507,0.026206814,-0.007949539,0.0012869183,-0.017365724,-0.016875511,0.06815215,-0.11404368,-0.01976992,0.047185887,0.00698015,-0.08654074,0.005074794,-0.10251227,-0.013252461,0.019535044,-0.00020911376,0.032771084,0.08964943,0.052245542,0.04724903,-0.023397652,0.04624195,-0.008263803,0.021079466,0.007273602,-3.550843e-08,0.06676922,-0.10047508,0.029277358,-0.020252585,-0.024549088,0.0023232165,-0.014112277,0.012156083,0.019733274,0.01696557,0.018931985,0.123609,-0.018898105,-0.03511045,-0.0010032589,0.03240465,-0.086729206,-0.009819037,-0.007951757,-0.03502465,-0.06914161,0.014429843,0.004759516,-0.001411089,-0.007910087,-0.085701086,-0.03637422,0.07976607,0.051988717,-0.074225284,0.018103445,-0.03315168,-0.0325339,-0.021710586,0.02384713,0.04255477,-0.029328292,-0.088345885,-0.029711576,-0.0031362835,0.024834203,-0.03800642,-0.043082245,-0.018495051,0.01344628,0.024970304,0.0024791716,-0.0082110185,-0.11816983,-0.07535595,0.06559683,-0.032808565,0.001384789,-0.00854732,-0.14693445,-0.0012744442,-0.0030865567,-0.08881264,0.0033381633,0.007574843,0.07250449,0.02078497,0.14579202,0.05829309 +3.5.1.94," Forms part of a putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form gamma-glutamylputrescine, which is oxidized to 4-(gamma-glutamylamino)butanal and then to 4-(gamma-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase).",384,1.0,-0.056110296,-0.112610504,-0.04449902,-0.03590304,-0.0014913842,0.07788572,-0.04276833,0.032172304,0.028099474,0.017013568,0.032887112,0.026399149,0.016424317,0.09562319,-0.08031967,0.0065715467,-0.028670376,0.027431307,-0.035860427,-0.048694313,0.019963188,0.059984583,-0.058243535,0.004406639,0.013629664,0.02036853,0.057639826,-0.034449063,0.00086212147,-0.033992905,-0.09639465,-0.14168298,-0.019565705,-0.052398995,0.049431078,0.053428404,-0.016995696,-0.061008167,0.051363707,-0.022364238,-0.06112247,-0.001067793,-0.005852798,-0.012126677,-0.00803026,-0.041749004,0.08050548,-0.011059,0.059570976,-0.077680364,-0.008413268,0.018128658,-0.07301072,-0.027722966,0.08520508,-0.0004985014,-0.1057518,-0.036048148,-0.02350115,0.03361664,-0.01003806,-0.041534256,0.03312767,-0.046352543,0.033766188,-0.026928877,0.06832177,-0.04113544,0.005475548,-0.062185608,-0.013662366,-0.049607977,0.029588489,0.026009567,-0.043678638,-0.0024580422,0.0069854567,0.03533497,0.069565766,0.0035528562,0.07076885,-0.08479291,-0.06523394,0.11447341,-0.048526,0.009468705,0.005768692,0.0586071,0.100794934,0.026407864,-0.02104056,-0.025063258,-0.040506348,-0.06085242,-0.018034931,0.010224723,-0.04426061,0.022469398,0.03735972,-0.035004605,-0.037392206,0.062451273,-0.004239515,-0.015718807,-0.0023562526,-0.017188622,0.033729773,0.10519616,-0.008995357,0.04808318,0.044631895,0.035822097,-0.01796982,0.059405297,-0.058176383,0.06538151,0.09256466,-0.07028917,-0.09638918,-0.054299135,0.01854626,0.017239355,0.060411654,0.09318013,-0.068682976,0.025535641,-0.029392477,1.8935462e-33,0.038839936,0.06264127,0.024891362,-0.04018307,0.031064823,0.05506415,-0.11570947,0.07937387,0.034546554,-0.039574243,-0.09980124,-0.079708114,0.029155286,-0.017443009,-0.020039903,-0.046352863,-0.031751327,0.01216959,0.01342601,-0.0050526536,0.011570647,0.07661496,0.008454049,0.033955008,0.015375785,0.016318647,0.003582478,-0.015220846,0.017393967,-0.025514435,-0.03569643,-0.070873305,-0.09882875,-0.032792393,0.044429928,-0.020812953,-0.042679645,-0.01323195,0.085759684,0.070500776,0.026329676,0.030714395,-0.08286569,-0.034525707,0.036047358,-0.027149092,-0.03819576,0.123364925,-0.008410656,0.06651744,0.005789586,-0.06765318,0.08399115,-0.01587042,-0.067820266,-0.0062511275,-0.02529676,-0.043010753,0.066421665,0.053764872,0.013618829,0.024935719,-0.028514907,-0.0022469473,0.05217207,-0.02627984,-0.107370585,0.007501982,0.015729694,0.046830267,-0.052803766,-0.026144968,0.027206386,-0.0064865034,0.0010537265,-0.11485174,-0.105261534,0.10378494,0.05074644,0.0011143946,0.0053451117,0.010564078,-0.04037983,0.04913351,-0.011802618,0.07233193,0.00529258,-0.039946117,-0.00052652817,0.049718,0.04772554,-0.053879302,0.0059199953,0.0018324115,0.009055281,-3.0810835e-33,0.074509434,-0.13316308,0.0077613057,-0.032238144,0.01723374,-0.012385574,0.0038645521,0.015265609,0.04422275,-0.025188461,-0.0025121197,0.013105266,-0.017239613,-0.061313696,-0.026649902,0.009006512,-0.040511254,0.046953317,-0.077205665,-0.049547877,0.0032152343,-0.010717383,-0.027636508,0.022486333,0.09247896,0.0539898,0.050641935,0.020072997,-0.011984692,0.07992727,-0.007600555,-0.027349409,-0.04490056,-0.021336343,0.008628489,0.039116837,0.011951361,0.068430446,0.0047663385,0.011997904,0.006601729,0.10028362,-0.038792986,0.11237073,0.008524021,0.11121447,-0.069881886,0.018544143,-0.060688306,-0.074589975,0.04767255,-0.063080475,-0.04556689,-0.025378518,0.007070071,0.011346005,0.02803178,-0.023175308,-0.05205664,0.02784554,-0.02001676,-0.100536525,-0.00023194138,-0.034524675,0.0416759,0.020269124,-0.019451154,0.013281877,0.013318559,-0.020175293,0.0035078167,-0.11553134,0.042154394,0.037914902,0.052967582,-0.0072267503,-0.07563134,-0.04598199,0.05809987,-0.053225115,-0.01574529,-0.021538287,-0.044309676,0.012913936,0.04153037,-0.041937917,0.064458854,0.18262352,-0.0115668755,0.0052635986,-0.072212264,0.06731196,-0.003782001,0.095980376,0.060516037,-4.250817e-08,0.040117733,-0.07188406,0.014627111,0.053854104,-0.014650017,0.07468738,-0.017210286,0.05219632,0.092857845,-0.072671115,-0.042214673,0.088436276,-0.023742273,-0.010785366,-0.03314167,0.02546125,-0.027979732,0.0004443317,-0.038782265,0.03646783,-0.09706575,-0.0057663918,-0.13018127,-0.03146739,-0.0015640287,-0.07275686,0.029266225,0.08485597,-0.015358658,-0.07150781,0.021432023,-0.02741263,0.011191323,-0.05537149,-0.07785968,-0.03288803,0.06413029,0.012849327,0.06828063,-0.016378822,0.0003675048,0.009896901,-0.02900091,0.020810869,0.022352334,0.039537553,-0.06837534,0.06142779,-0.03796392,0.038898755,0.020337129,0.034782737,0.017169178,-0.049113214,-0.07580897,-0.026570411,-0.021907983,-0.07687011,0.010461275,0.008004193,0.0077610877,0.036174867,0.1652126,0.028766396 +3.5.1.95," Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.2.1 (barbiturase).",384,1.0,-0.00035602323,0.0019304522,-0.017962338,-0.072696514,0.090173475,0.02871049,-0.0458711,0.033353575,0.014193919,0.013967477,0.016822847,-0.011462051,-0.053365596,0.0069467574,-0.0080459565,-0.011135868,-0.12621674,-0.0050987056,-0.036992162,-0.08094215,0.05285317,0.02852191,-0.031501222,-0.012427157,-0.028085932,0.017717779,0.057999283,0.012083063,-0.026464192,-0.07360482,0.057697866,-0.10708282,0.07123649,-0.090190284,0.027080825,0.08311152,-0.023590107,-0.06533049,0.0713262,0.03826854,0.023101952,0.0073422217,-0.077275835,0.014843025,0.012601107,0.022326153,0.041089777,0.005636538,-0.018474631,-0.030921137,-0.0023659565,0.02223126,-0.046484783,0.015744597,0.03045506,-0.0017502091,-0.028588705,0.012082382,-0.063691,-0.01303837,0.010031264,-0.010190384,0.050658863,-0.03939094,-0.042782087,-0.024636118,0.07362047,-0.05609702,0.05248941,-0.030701363,-0.05179684,-0.09827947,0.0065021245,0.02613246,-0.034303803,-0.0089452695,0.0063747475,-0.097971894,-0.012838367,-0.02081701,-0.062088232,-0.08605292,-0.008320099,-0.020141302,0.021603104,-0.06344698,-0.017119095,-0.09608497,0.045586642,0.076264106,0.045101136,-0.006944087,0.01636016,-0.008996367,0.02462625,0.04259847,0.009912693,0.06142836,0.042441603,-0.061593316,-0.03467386,0.06748829,-0.13920072,-0.03831167,0.016433982,-0.00991448,0.063228376,0.07510738,0.0044314624,-0.0022348172,-0.006334511,0.02983566,0.003777262,0.0356428,-0.036188703,0.039888177,0.05873716,-0.038914707,-0.063930124,0.026654275,0.0111502195,0.012937697,0.043264378,0.10857631,-0.08745771,-0.029961448,-0.045784228,1.9419732e-33,0.029815186,-0.017465116,0.0030330264,-0.050509352,0.031055655,0.044487298,-0.0969869,0.009803487,-0.010699115,-0.100898966,-0.06834755,-0.10110639,0.036470532,0.039825324,-0.01861439,-0.049898528,-0.08650091,0.06069092,0.04096704,-0.042027462,-0.019752443,0.06868974,0.0057703624,0.0020391433,0.029422805,0.050239637,0.010505776,0.03502427,0.025581997,-0.01363346,-0.00039241172,-0.11815921,-0.09726387,0.0030349742,0.033435997,0.043530203,-0.040753752,0.023389202,0.00043421364,0.056775615,0.010609658,-0.0110703325,0.019400988,-0.025887392,-0.0038966767,-0.051041767,-0.042935237,0.09866022,0.024157409,0.0145668,-0.06444942,-0.050154775,0.09928551,-0.02724475,-0.046238936,-0.032453585,-0.06429757,-0.04027379,0.02212829,0.019052703,0.06998664,0.13220902,-0.030196086,0.029610056,0.07900493,-0.021815557,-0.0022566663,-0.0024226776,0.06863169,0.019233264,-0.09321762,0.0066563184,0.04385971,0.0030523883,0.03649585,-0.028309306,-0.13532509,0.09016049,-0.021067724,0.0026716124,-0.03850684,-0.027598899,-0.0032512571,0.023663815,0.010021128,0.06578402,0.011112371,-0.05997646,0.0627706,0.046727818,0.032508466,-0.08243166,-0.062090937,-0.0064804633,-0.007197161,-2.8270498e-33,0.08505127,-0.061868094,0.025530787,-0.019320227,-0.053976305,0.034782242,-0.00042532754,0.05258646,-0.028685478,-0.019191809,0.028952638,-0.0059399246,0.0020444724,-0.14163452,-0.008996735,-0.03175342,0.025609158,0.07988382,-0.005854773,-0.032836314,-0.01518902,-0.020848155,-0.031912573,0.039853558,0.04059694,0.030886006,0.02662484,-0.01326488,0.06900577,-0.038705617,-0.027745046,0.07833955,-0.06715896,-0.028085483,-0.0077581084,0.0464549,-0.066970535,0.0009768363,0.034403834,-0.03911052,0.05900337,0.055110116,0.021598268,0.020307649,0.06371843,0.091904856,-0.07319146,0.03685877,-0.0112335645,-0.06559861,0.05606389,-0.012150892,0.009456039,0.0071812687,0.1069352,-0.039322384,-0.04271285,0.055717956,0.03731174,-0.0064488254,0.00812255,-0.026246306,0.03329132,-0.0043135765,0.015912153,-0.03488476,-0.028673096,0.08997906,0.025727766,0.049320374,0.11413493,0.023749592,0.03322105,-0.020737791,-0.092919186,-0.038313497,-0.030263454,0.032321047,0.047662742,0.011331128,0.0539777,-0.0095748035,0.011121084,-0.07607822,0.019013278,-0.04846766,-0.045867972,0.117190525,-0.018202314,0.0194358,-0.06952435,-0.094223805,-0.06756677,0.04939304,0.03913547,-3.650422e-08,0.053197943,-0.030712575,0.024992015,0.033994906,0.017361432,0.058832202,0.011416687,0.067617126,0.07744716,-0.04590747,0.05885592,0.046881907,0.05186118,-0.06838081,-0.02755502,0.035873093,-0.028694961,0.032274455,0.0768132,0.047921307,-0.08992705,-0.02012645,-0.14207453,0.03746316,0.08827467,-0.01789212,0.046987243,0.02491256,0.012205,-0.07642732,0.055704676,-0.018820025,0.107599005,-0.02375405,0.010523151,-0.023058642,-0.05292843,-0.0031019393,0.011385037,0.0410964,-0.068858854,-0.036406364,-0.04499695,-0.0022502532,0.055063285,0.030226314,-0.019421393,0.09724121,-0.0761494,-0.074037395,0.07637406,0.009615353,0.061067093,-0.04494585,-0.13644636,0.038534053,-0.0048169205,-0.12842445,-0.011549234,-0.020798497,0.07457196,0.029838575,0.11690997,0.033089064 +3.5.1.96,"Requires Co2+ for maximal activity [1]. N2-Acetylglutamate is not a substrate. This is the final enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase).",384,1.0,-0.059623223,-0.0825038,-0.112987354,-0.028406134,0.010469151,0.0591942,-0.028697109,0.0114502525,-0.0077244635,0.018732386,0.005021758,-0.045009397,-0.025032613,0.019081194,-0.08683977,0.0048427894,-0.066682085,-0.064738445,-0.0058921045,-0.088043734,0.060689244,0.06113141,-0.07545096,-0.09274251,0.08720743,0.021919556,0.00657483,-0.06464632,0.009998072,-0.07985339,0.028919855,-0.10488559,0.01398343,-0.01805496,0.07816877,0.047755443,-0.06927334,-0.032092668,0.11643971,0.006146656,0.010141764,-0.017976066,-0.065231085,-0.05978937,-0.014950733,-0.012634017,0.0014756231,-0.022453168,0.006217721,-0.011019925,-0.04283546,-0.02133376,0.00033165255,0.03268822,-0.010414373,0.0467897,-0.13104048,-0.04646233,0.008486547,0.031386167,-0.022051165,-0.0041027083,-0.008194403,-0.086308934,0.051179457,-0.036260698,0.06403333,-0.10918236,0.053420052,0.0059920796,-0.05178289,-0.055387784,-0.05477153,0.01386833,-0.040243156,-0.019715212,-0.007242088,-0.024436282,-0.00054617337,-0.06560289,0.05185362,0.074597254,0.09787703,0.069454946,0.033643506,-0.018344529,-0.026643055,0.052920587,0.05870729,0.06134382,0.0036381285,-0.030904394,0.03753935,-0.000307038,-0.026298294,0.036272816,0.024215002,0.06207807,0.030428445,-0.034920596,0.0032962775,0.052354213,-0.011924704,-0.09199467,-0.021462986,0.03460985,0.07937732,0.09046567,0.025237683,0.019392557,-0.016327757,0.005424622,-0.0054969327,-0.031143354,-0.0027963044,0.117288254,0.036509864,-0.049352314,-0.05465521,0.022926189,-0.017455686,0.05990704,0.12269439,0.085456304,-0.05811312,0.10968423,-0.06919147,6.987344e-33,0.041491523,0.0012866384,0.03231961,0.0097837895,0.010853708,-0.01248007,-0.12441662,0.08780385,0.05012026,-0.050369672,-0.05140502,-0.04604606,0.06281609,-0.0021140939,0.0038442202,-0.008456556,-0.009298538,-0.033164483,0.046650987,-0.02043996,-0.025387377,0.039679375,-0.020205917,0.052109607,0.0035928513,0.0024231193,0.033942048,0.06209565,0.0110765975,-0.011858526,0.035170756,-0.10880458,-0.07265912,0.0020432035,0.041738886,-0.033363417,-0.00562092,0.03598007,-0.011352388,0.092625156,0.00052900723,0.063150875,-0.033108916,-0.041524023,0.048303153,-0.037217677,-0.033960752,0.101925425,0.026845751,0.09184071,0.021341559,-0.015896644,0.11081754,0.004647883,-0.04411143,0.037476677,-0.013949793,-0.00038710117,0.07237721,0.06908785,-0.0042318082,-0.0032160792,0.0027884115,0.02325625,0.0014035222,0.07859673,-0.10762296,-0.070008114,0.03132008,0.053149525,-0.105907105,-0.026715076,0.06857807,0.03462603,0.07147383,-0.05409746,-0.048216574,0.06446319,0.009354088,0.02276312,-0.031992126,0.025116831,0.056673817,-0.037011694,-0.01776012,-0.035324965,0.009375789,-0.10300334,-0.02190388,0.022853464,0.009653552,-0.042430364,-0.064908564,0.010561957,0.047103565,-6.506773e-33,0.17028432,-0.06253913,0.008458216,-0.082702376,-0.100162774,0.074530564,0.022484642,-0.045054913,-8.929664e-05,0.015399894,0.117653444,0.063263126,0.09131091,0.024360886,0.04423974,-0.06214823,-0.012455947,0.081377804,0.045889825,0.00951048,0.008868575,0.08914835,-0.05954383,0.0011786657,0.04782317,0.025140436,-0.0037712879,0.008872714,0.031831246,0.04192264,-0.022986857,0.0025770015,-0.02784015,-0.024024576,-0.05478806,0.022587867,0.014855116,0.025401093,-0.14856918,-0.015253341,-0.030084796,0.029022252,0.027918104,0.05841661,0.02613002,0.014820978,-0.06180855,-0.054537516,-0.11876542,-0.059767812,0.053170644,-0.026358683,-0.035197135,-0.008779489,0.019072995,-0.0059309034,0.043915562,0.041277215,0.022258863,-0.058623854,0.018792488,-0.016287893,0.015088453,-0.06753394,0.08685293,-0.007862575,-0.0356562,0.07094507,0.0033279953,-0.025361748,-0.025354708,-0.03024745,0.081394985,0.034768827,-0.025749313,-0.0012424582,0.013518352,-0.06970529,-0.0018525397,-0.09176543,-0.02248926,-0.044369046,-0.04156866,-0.036341608,-0.060327236,-0.024603115,0.051743492,0.09110775,-0.0061960313,0.06967397,-0.061948787,-0.025981234,-0.048785094,0.058768522,0.0556964,-5.2882953e-08,0.012213765,0.006694099,-0.0127822235,0.01756831,0.022588935,0.07681266,-0.018585127,-0.024793983,0.04727178,-0.036159974,-0.0311527,0.101522416,0.037552446,0.05179584,-0.030996654,-0.015098005,-0.03498881,0.0004898736,0.016287256,-0.0023575632,-0.10343318,-0.0017188921,-0.0854652,0.03788428,0.043705374,-0.12552339,0.064236276,0.026765099,-0.019617762,-0.07084786,-0.028812153,0.016494408,0.07886762,-0.069677696,-0.021474777,-0.001905757,0.016454615,-0.037401114,-0.00949928,0.038156666,-0.006659418,0.038381066,-0.031335276,-0.0078009926,0.007099657,0.021111978,0.011299338,0.008191083,-0.027217947,-0.02492451,0.00577662,-0.04773115,0.007022023,-0.051139545,-0.07740328,0.014529615,-0.070099786,-0.068696074,0.016135903,0.0032546583,0.04219423,0.04164903,0.104031295,-0.03657218 +3.5.3.23,"Arginine, N2-acetylarginine and N2-glutamylarginine do not act as substrates [3]. This is the second enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase).",384,0.9999999,-0.04706566,-0.10835355,-0.10519343,-0.04284718,0.023331495,0.039631795,-0.013559564,-0.0012475608,-0.0050332923,0.00573509,0.009352305,-0.045843024,0.0061101983,0.021668259,-0.0809883,0.0043921536,-0.09604901,-0.060984056,0.011904492,-0.08434783,0.054559983,0.094705515,-0.05637232,-0.096914336,0.092516325,0.0108056115,0.0021871445,-0.05440591,0.0061010257,-0.07169396,0.015716188,-0.1133293,0.013116034,-0.018650513,0.108130716,0.036226727,-0.08366684,-0.022009257,0.09665651,0.005087566,0.0060824277,-0.002504936,-0.06398089,-0.064421356,-0.011241363,0.022551036,0.030885663,-0.011926941,0.00052619126,-0.01153923,-0.03230981,-0.026529972,0.002308667,0.033299744,0.0011775297,0.039592754,-0.14666933,-0.046395607,-0.011734026,0.047234796,-0.022070874,0.003083684,-0.0030790495,-0.09886478,0.06604245,-0.004803701,0.06371549,-0.09775504,0.06586097,0.00042431438,-0.056499783,-0.05436078,-0.05096457,0.023772672,-0.03331039,-0.018541653,0.01880861,-0.00869211,-0.025082083,-0.07869399,0.03861093,0.067636095,0.10606579,0.06530676,0.00829473,-0.032245602,-0.041593984,0.06013435,0.053521127,0.054744665,0.02023873,-0.03745328,0.056968734,0.0016599589,-0.0035056127,0.019126745,0.0060710893,0.060823057,0.057997394,-0.036026746,0.001607065,0.04657456,-0.025746262,-0.0699153,0.013615578,0.0486724,0.056640122,0.06660145,-0.0010686544,0.01869066,-0.0016649314,0.024886752,-0.0014725194,-0.0069598686,-0.020043168,0.09516472,0.053741686,-0.040435918,-0.066759214,0.03914228,-0.033168375,0.0757432,0.11758518,0.08368439,-0.0590906,0.11029492,-0.09597788,6.8081775e-33,0.009528419,-0.0065612495,0.03253353,-0.006192515,0.021937208,-0.006178155,-0.10464571,0.094621085,0.07520477,-0.03673499,-0.06522193,-0.047904152,0.08583124,-0.020885807,-0.0030841837,-0.016156679,-0.024275498,-0.008719959,0.042846493,-0.01100298,-0.031648327,0.043933023,-0.018712256,0.034414656,-0.012771078,-0.019551182,0.02728669,0.06223239,0.029398134,-0.027494788,0.020314433,-0.12153673,-0.061362416,-0.022383058,0.035840932,-0.0466422,0.02068391,0.032136787,-0.0060227183,0.09202373,-0.02957467,0.052494325,-0.036925774,-0.03230927,0.049877718,-0.02062278,-0.047678996,0.09431017,0.0069736545,0.07802808,0.031496845,-0.026480203,0.12482738,-0.017075233,-0.029746057,0.0099737765,-0.0038947987,0.0021812906,0.073758945,0.06692052,-0.004035131,-0.019777682,0.0070240134,0.008966673,0.008981321,0.076988086,-0.09162015,-0.067803346,0.023551947,0.069982365,-0.11138152,-8.705892e-05,0.07242591,0.020495016,0.058921415,-0.044646442,-0.07240454,0.060314342,0.010798055,0.011921338,-0.049721055,0.030533563,0.038598254,-0.02069508,-0.021279259,-0.04968408,0.014250186,-0.09967029,-0.003610884,0.028421447,0.013519969,-0.034372214,-0.09484473,0.016911801,0.0574212,-5.8523015e-33,0.15612188,-0.033098906,2.7025986e-05,-0.058435723,-0.09038693,0.06548241,0.023962803,-0.0051564593,-0.0031814943,0.0015646524,0.09407834,0.064438045,0.08512455,0.012711649,0.03492781,-0.06552237,-0.010049738,0.06866387,0.051593393,0.011274655,0.0007826039,0.076545626,-0.07097723,-0.0003508248,0.013914947,0.029444978,-0.004499841,0.0062386813,0.020505661,0.041833207,-0.029973492,-0.008804678,-0.011850252,-0.021255048,-0.035964783,0.029122123,0.043850467,0.028653955,-0.14106275,-0.035212982,-0.022696966,0.05161332,0.029813316,0.07359738,-0.015094248,0.040035278,-0.04887144,-0.037675552,-0.1149256,-0.07033618,0.045571383,-0.05104933,0.011636256,-0.013302405,0.0021090386,-0.009429025,0.05574514,0.03884637,0.015579072,-0.008181292,0.029282162,-0.03080524,0.014144004,-0.056632914,0.07665063,-0.019002788,-0.045920204,0.06541831,0.015013343,-0.018525504,-0.032737374,-0.04372643,0.084921114,0.040345583,-0.028295053,0.0016335222,0.022936486,-0.067885056,0.00571911,-0.09620115,0.0077452757,-0.056182127,-0.04339288,-0.011125122,-0.06285715,0.0016179852,0.077634096,0.112195514,0.010019911,0.050036915,-0.05462663,-0.015152218,-0.059228487,0.062112212,0.056895677,-4.983267e-08,0.033282224,-0.02183043,-0.011824953,0.031701367,0.014240556,0.08705266,-0.033962693,0.007532311,0.028716575,-0.03896336,-0.0086621,0.07836789,0.0031526189,0.042386662,-0.024818625,-0.01005996,-0.05128338,-0.0021210867,0.013490293,0.0037043872,-0.12110392,0.026118714,-0.082606465,0.020560209,0.04900458,-0.11532498,0.046996046,0.031077143,-0.017942809,-0.08369884,-0.020000761,0.016791366,0.06635793,-0.072434984,-0.031047404,-0.02039273,0.010108312,-0.058081195,0.006318863,0.03495811,-0.008775029,0.053997938,-0.042956423,-0.015092725,-0.011280839,0.015268198,-0.0014259187,0.023885671,-0.0138884,-0.04126195,0.006345838,-0.03757273,0.031219477,-0.050089575,-0.084446885,0.0038428989,-0.083660424,-0.07405457,0.029445458,0.031101784,0.032893676,0.035888243,0.11147008,-0.017257191 +4.1.1.86,"A pyridoxal-phosphate protein that requires a divalent cation for activity [1]. N4-Acetyl-L-2,4-diaminobutanoate, 2,3-diaminopropanoate, ornithine and lysine are not substrates. Found in the proteobacteria Haemophilus influenzae and Acinetobacter baumannii. In the latter, this enzyme is cotranscribed with the dat gene that encodes EC 2.6.1.76, diaminobutyrate---2-oxoglutarate transaminase, which can supply the substrate for this enzyme.",384,0.99999994,-0.034306865,-0.07329483,-0.11652478,-0.08046441,0.017102802,0.05818006,-0.025825718,0.07194757,-0.03171198,0.06126996,-0.00815034,-0.044346478,-0.057072133,0.11324493,-0.010737823,0.092226274,-0.06967284,0.0035784333,0.009893811,-0.04434828,0.12629488,0.047332387,-0.01252048,-0.08118622,0.019400148,0.044986967,0.052446723,-0.0010952026,0.012879027,-0.06846449,-0.05879224,-0.078451395,0.014496377,-0.06319434,0.09251236,0.06448478,-0.09149631,-0.09437247,0.08857727,-0.0106856525,0.08527508,0.025967492,-0.03244784,-0.041719794,0.03815464,0.017320367,0.06653854,0.06349184,0.07619658,-0.032982685,-0.01960864,-0.010732025,-0.011209349,0.032514863,-0.05097724,0.036756337,0.012819974,-0.05416602,-0.024041753,0.025467353,0.020983126,-0.0021145195,0.08696018,-0.056501348,0.013029423,-0.07116891,0.0011548582,-0.031578433,0.016360255,-0.027694685,-0.077821024,-0.046016954,0.04054964,0.07327933,0.015935635,0.034842733,0.020586763,0.0006791278,0.014468667,-0.022400832,0.023319053,-0.022143144,0.020739336,0.10119276,0.016482586,-0.04953357,0.029279372,0.02969273,0.04143541,0.023453057,-0.00038884755,-0.0019835774,0.016192347,-0.02921896,-0.05532798,-0.0051780255,-0.020410601,0.00258574,0.023484634,-0.0074305576,-0.031482868,0.022640666,0.03156685,-0.040610876,-0.09041824,-0.029522698,-0.011886932,0.09336216,0.0541043,-0.012006918,-0.04796454,0.037226237,0.0045456765,-0.058674574,0.011908611,0.034400374,-0.00012850786,-0.07003331,-0.05268109,0.024542065,0.052127864,-0.0630923,0.04444538,0.09663972,-0.019338299,0.051874153,-0.08038413,4.9818255e-33,0.097444646,0.056063116,0.07041475,-0.0040245797,0.014339961,0.023275781,-0.08827378,0.017155504,0.04426448,-0.06147894,-0.08149494,-0.05733865,0.08371822,0.009220408,-0.054300305,-0.03808126,-0.04721205,0.02206063,0.067250185,0.009801809,0.056821726,0.037573792,-0.010042235,0.04560009,0.084352694,0.046526596,0.015348799,-0.019699274,0.013411235,-0.012932589,0.025479065,-0.11071968,-0.08479223,-0.07315726,0.030828696,-0.07007682,-0.05145035,-0.05110728,-0.050656356,0.024882944,-0.0225141,0.016531322,-0.0050705704,-0.017631447,0.08331656,-0.107003465,-0.045154452,0.124218576,-0.02780316,0.08239462,0.06505517,-0.061220217,0.09643958,-0.04409665,-0.07640272,-0.04563043,-0.051295932,-0.050135456,0.08799975,0.003941956,0.12112999,0.019098904,-0.03201331,0.01975928,-0.047138292,0.002084376,0.018502185,-0.038631182,0.026433874,0.049147133,-0.014800976,0.0059186863,0.035002783,0.051036526,-0.01931583,-0.060671236,-0.070949934,0.006731525,0.024898406,-0.023485461,-0.009948748,-0.025875092,0.029628444,-0.044658586,-0.008345585,-0.06527824,0.0050529046,-0.034328148,-0.0067793527,0.016801462,0.02423646,-0.00130236,-0.06748042,0.03824847,0.029398922,-5.098735e-33,0.1034267,-0.117937066,-0.012042632,-0.06814898,-0.03370652,0.015683632,0.035560865,0.06402387,-0.004903008,-0.010044428,0.067218535,-0.021961669,0.040190123,-0.065332845,0.047353633,-0.00688572,-0.04372393,0.07494869,0.040573522,0.04687966,0.01674678,0.0382837,0.019550411,0.008178393,0.05975435,0.06457848,-0.05511346,0.028982073,0.005441135,0.051453315,-0.025329536,0.06188305,-0.012796846,-0.07358471,-0.062549286,0.04363767,-0.0034350706,0.0018495058,0.007933109,-0.032831226,0.011120624,0.10101457,0.026317,0.07707818,-0.054075558,0.051888883,-0.030334255,-0.021976443,0.0009894783,-0.07711314,0.01095756,-0.023617873,-0.013267131,-0.02863851,-0.011611669,0.057280995,-0.05482864,-0.008216958,0.0053975754,0.026882406,-0.0034613986,-0.12662801,0.008673592,0.018935123,0.044402815,0.07479567,0.02212814,0.07551749,0.023608617,0.0046659606,0.039260816,0.03034538,-0.0030319397,0.037346683,-0.059101917,0.03296213,-0.05761002,0.012240157,0.027917562,-0.008695587,-0.030070482,-0.037116684,-0.044601783,-0.0939309,-0.00059022766,-0.050459612,0.056279156,0.11417178,-0.010260976,0.021183798,-0.02056365,-0.039017238,-0.024288671,0.04555963,0.05378174,-5.2574254e-08,0.07596357,-0.058746018,0.03015478,-0.03168605,0.010181484,0.031765133,-0.04764751,-0.0017778616,0.09895735,-0.07991875,0.023952037,0.041071035,-0.02666062,0.0043457025,0.06229054,0.04898155,-0.058559526,0.044695895,-0.020529632,0.03727665,-0.057326097,-0.01642901,-0.16043879,0.021284886,0.049829073,-0.028355462,-0.0078071286,0.00051466096,0.0031344919,-0.038363643,0.0063766525,0.017056927,-0.004318283,-0.06986167,-0.07686314,0.043216586,0.021179473,-0.070679605,-0.058936514,-0.035308886,-0.0050279624,-0.05221097,-0.033242688,-0.025277916,0.04778656,0.04049503,-0.018144744,-0.006445882,-0.07155607,-0.088684134,0.08104447,-0.07829822,-0.012446308,-0.09196431,-0.15010872,0.059206918,0.012333654,-0.026754903,-0.022103861,-0.029933061,-0.010734254,-0.012792588,0.1446472,0.0059923907 +4.1.3.39,"Requires Mn2+ for maximal activity [1]. The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH [1]. In some bacterial species the enzyme forms a bifunctional complex with EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase [4,5].",384,1.0,-0.046791837,-0.030493412,-0.083800554,0.009930778,0.0437643,0.059185345,-0.089464456,-0.011823876,-0.011123083,0.004804341,0.04164389,-0.0998706,0.000978502,0.038048476,0.0049251546,0.08735941,-0.037943035,-0.020886615,0.02616158,0.025358815,0.08798364,0.031516515,-0.056364838,-0.027904013,0.056313086,0.059903935,0.04198298,-0.022425894,-0.038104698,-0.017858433,-0.06430894,-0.067993104,0.12783198,-0.11323739,0.053980783,0.07927567,-0.05001213,-0.038174078,0.023066675,0.001859081,0.022836257,-0.0177131,0.047315806,-0.08705401,-0.02900421,-0.043752514,0.11883576,-0.008911479,0.04308162,-0.007489318,-0.04326959,-0.03784551,-0.0022846707,0.020141171,0.036359705,0.010128879,-0.05173712,-0.0056616925,-0.064323545,-0.047048178,0.061822902,-0.059663814,-0.015462221,0.046147257,-0.0026574759,-0.055106707,0.040885057,-0.07292508,0.006159585,-0.055530503,-0.012968532,-0.04874721,0.005213374,0.017798826,0.018488666,0.0057672453,0.023333797,-0.06310854,0.10040957,-0.014942893,-0.004481327,-0.042373817,0.023946216,0.053350106,0.024086945,0.02318731,0.07342455,0.021390315,0.010428389,0.026585389,-0.0073035643,-0.0021519815,-0.05770368,-0.047379643,-0.028348055,0.030416654,0.027672889,0.0758812,0.052656993,-0.056792565,-0.01154355,0.10256775,-0.058576755,-0.105457135,0.007689418,-0.014602986,0.038300972,0.1422999,0.022025123,0.043018777,0.040810734,-0.025381729,0.012441994,-0.0029207114,-0.0034877725,0.08932478,0.08386375,-0.10345395,-0.09738495,-0.042163897,0.04520368,-0.031195099,-0.0012773357,0.07645727,-0.0357039,0.04140442,-0.09547415,2.7152986e-33,0.08300975,0.030039735,-0.04844995,-0.06229213,0.045944627,-0.0046866797,-0.090369046,0.031883195,0.029415254,-0.03804343,-0.057561174,-0.05516308,0.06749915,0.052516036,-0.013536499,-0.028980935,-0.029361544,-0.04363799,0.100545585,0.04079074,0.041170496,0.06029483,-0.023466572,0.052551147,0.029463235,0.03775084,0.12882133,-0.022856375,0.0024812575,-0.006501039,0.032065902,-0.14903219,-0.16223074,-0.0680821,0.05383804,0.007835799,-0.06278414,0.0018065303,-0.025693573,0.030792017,0.021153852,0.08184683,-0.058147,-0.016404051,0.057350628,-0.10220761,-0.03295265,0.1377527,0.018107219,0.08514207,-0.016214384,-0.037885092,0.09438373,0.015605035,-0.08097534,0.030770332,0.017279297,0.054357577,0.016822606,0.05057975,-0.01164644,0.04558991,0.017792104,0.08330715,0.010481686,-0.00072689867,-0.039038215,-0.057472423,0.01802312,-0.0025708494,-0.04872111,-0.027235936,0.040821668,-0.050527096,-0.032038175,-0.06833534,-0.09281742,-0.02057725,0.042031076,0.034855466,0.02642906,-0.039796975,0.057716634,-0.007641809,-0.029200258,0.015626578,-0.056285586,-0.019599382,-0.012449431,0.032514226,0.045160603,-0.040208388,-0.012443666,0.008167343,0.010837155,-4.1673754e-33,0.068742454,-0.094393946,0.07684798,-0.10353101,-0.08341119,0.097861744,-0.016622473,-0.051383894,-0.010371926,-0.006776117,0.082193606,0.043719605,0.069204524,-0.03775213,0.018158386,-0.039969202,-0.01888214,0.088548765,0.017094465,-0.027794791,0.008521671,0.08941229,-0.008842197,-0.0013093255,0.0738593,0.011272379,-0.03114024,0.040710185,0.015597554,0.033940006,-0.023992123,-0.008598989,-0.07404273,-0.02633877,0.030163452,0.06360463,-0.07691405,0.032640703,0.07107664,0.08262176,0.024597408,-0.03923496,-0.04808347,0.10182146,-0.002831086,-0.024549551,-0.12183865,-0.0036556604,0.015522886,-0.020728754,-0.014256651,-0.01965876,-0.09194453,-0.03469952,0.030939376,0.0029911136,-0.016131418,0.015634784,0.013176067,-0.07079245,-0.067694254,-0.07373417,0.047279827,0.0043059164,-0.026200194,0.06095127,-0.040188,0.019495202,-0.008382416,0.0068056467,0.03006754,-0.018357987,0.000690386,0.03342701,-0.02135101,-0.060529668,-0.017848065,0.008058508,0.04157961,0.00771253,0.03926217,0.010550607,0.013075719,-0.05497698,0.02761469,-0.035358675,0.0516101,0.09193086,-0.081603125,0.0051609725,0.002980742,-0.01960278,-0.008289026,0.02593474,0.014478753,-4.7140254e-08,0.00647537,-0.054559473,0.09182152,-0.02525491,-0.019083355,0.016675053,-0.016992865,-0.047456946,0.042932466,-0.03438836,0.016624905,0.07512618,0.02606694,0.015163469,0.032391872,-0.031787854,-0.015828444,0.01296689,-0.053480294,-0.050296776,-0.07179539,-0.08456243,-0.13960397,0.045566272,0.020218,-0.0284655,0.014791072,-0.024210585,0.048051957,-0.026185665,-0.032145243,0.013822384,-0.012904814,-0.02715501,-0.07308375,0.010683933,-0.023971789,0.030473303,-0.060846947,-0.0133609995,-0.0074949446,-0.086834535,-0.038881034,0.024351124,0.021539887,0.004627515,-0.0026710366,0.040402107,-0.02826059,-0.015877329,0.05047574,-0.060820974,0.023826316,-0.043197427,-0.09471821,0.066650234,-0.007310365,-0.07592092,-0.012507446,0.039924648,0.03218731,0.045755155,0.10170931,-0.056751233 +4.2.1.108,"Ectoine is an osmoprotectant that is found in halophilic eubacteria. This enzyme is part of the ectoine biosynthesis pathway and only acts in the direction of ectoine formation. cf. EC 3.5.4.44, ectoine hydrolase.",384,1.0,-0.01803631,-0.015270513,-0.06537158,0.012951747,0.099862374,0.051041827,-0.0014655364,0.050909087,0.035515793,-0.0023102872,-0.010021616,-0.10357888,0.010670532,0.009771756,-0.052422088,0.044288497,-0.05471112,-0.018719023,-0.025809856,-0.020673787,0.06731922,0.09376692,0.026321335,0.029008763,-0.060985684,0.041913692,0.068009846,0.007353111,-0.050309855,-0.07514163,0.007897271,-0.07999379,0.11859456,-0.05454891,0.09696654,0.043379594,-0.037513576,-0.13337657,0.042586554,0.021485114,0.024192968,0.046214715,-0.047118947,-0.031091953,0.016033716,-0.01564896,0.025113145,-0.03406926,0.016985852,-0.0059166998,0.016784899,-0.09785836,-0.031223932,0.01535926,0.0101863425,0.050237786,-0.039173026,-0.07777345,-0.016379088,0.0152347,0.104377374,0.018204845,0.017528998,-0.044714883,-6.356366e-05,-0.024804568,0.060060646,-0.084653266,-0.0029562684,-0.05587698,-0.05395298,-0.12502688,0.05869189,0.1421203,0.027896162,0.004720678,0.04489329,-0.0451482,-0.015419385,-0.017749442,0.0015751814,-0.04621797,-0.014478043,0.06903474,0.017219286,-0.0651863,0.026273672,0.0040975087,0.04123575,0.076240584,-0.026853368,-0.06353255,0.016287178,-0.036037356,0.02705018,-0.010278157,0.027076257,0.040636968,0.020635245,-0.028829101,-0.031677704,0.013718129,-0.03003013,-0.016270427,0.015942944,0.0034527704,0.04473006,0.067509234,0.0048841904,-0.020365424,-0.00494783,-0.074548766,0.02245574,-0.009727453,0.010812942,0.05083414,0.0655511,-0.003744079,-0.021686364,0.056670703,0.044162728,-0.03533204,0.10426353,0.049037773,-0.0032148322,0.02034105,-0.1239089,2.1248357e-33,0.06757037,0.010833317,0.021075582,-0.053801097,-0.05240287,0.04885246,-0.025765551,0.023370491,-0.029840294,-0.17006253,-0.07653046,0.009300364,0.068634756,0.035166837,0.010480731,0.011058627,-0.075582795,0.00022087384,0.016849816,0.0098181125,-0.011209502,-0.04005406,-0.02118259,0.04446372,-0.019855361,-0.013289215,-0.022615427,-0.082554385,0.078798965,0.034654677,-0.03645459,-0.057925146,-0.018570881,0.033116333,0.059160396,0.052593824,0.0014224378,-0.04548319,-0.019122861,0.038507342,-0.024400814,-0.041404497,0.006665821,-0.018464237,0.0488297,-0.02846537,-0.123112775,0.06472289,0.048111215,0.013839264,-0.009174639,-0.030848395,0.10461418,-0.05490853,-0.03509771,0.06567357,-0.065286845,0.04574518,0.0755031,0.02971165,-0.0038575581,0.07877607,0.04785611,0.04105683,0.0065954006,0.014100846,-0.07431334,-0.038993146,-0.01990025,0.052448146,-0.10180731,0.009539122,0.07010015,0.095352955,0.01177534,-0.03517924,-0.111254714,0.085186176,-0.049012233,-0.01538676,0.052521598,-0.042189453,0.038362898,-0.027380796,-0.0085397065,0.026231708,-0.016855411,0.0069528017,0.005606556,0.044310316,0.004896005,-0.031648017,-0.054272164,0.03330168,-0.047823653,-3.177771e-33,0.10406441,-0.08935311,-0.012887628,-0.024591284,-0.03217232,0.047067672,-0.037839375,-0.03409847,0.0032890427,0.016497077,0.05235256,-0.0071642357,0.07694999,-0.116188094,0.029086169,-0.00013495986,-0.026238695,0.052006412,0.0124585545,-0.029215727,0.011174484,-0.039435577,-0.031749614,-0.0015910569,0.010808754,-0.0010937534,-0.07596038,0.009669219,0.059856813,0.04718439,-0.101915166,0.094777584,-5.7119483e-05,-0.12122651,-0.073369026,0.067747734,-0.04056412,-0.063377135,0.015253162,-0.0067763226,-0.02029741,-0.016765552,0.01913276,-0.0029980275,0.0711971,0.098377,0.072361365,0.05131145,0.041133996,-0.021798283,0.042027857,-0.04458354,0.01027391,-0.001953683,0.029857371,0.03649703,0.0032438526,0.0058715106,0.02119976,0.02059596,-0.009905806,-0.010033871,0.11263569,0.01650532,-0.0108852675,0.0045533073,-0.04269835,0.08084162,0.013674006,-0.01571885,0.033204652,-0.016398445,0.019636152,0.016893426,-0.035234794,0.033170573,-0.074751884,-0.038607787,-0.034105442,0.021567136,0.043521356,0.016533213,0.033549983,-0.0045095882,-0.035595264,-0.073338844,0.017865196,0.038345717,-0.09381366,0.005679826,-0.10942917,-0.043254066,-0.07640957,0.035963453,0.034686856,-3.8335088e-08,0.080563866,-0.0061629065,0.051169913,0.032552365,0.07038973,0.041186016,0.023109742,0.018833831,0.0678795,-0.0742426,-0.022322027,-0.0065056463,0.01405843,-0.021634845,0.024262344,0.056486413,-0.022875298,-0.0064132847,0.024021627,0.031282414,-0.034102686,-0.040578105,0.0034025558,0.016106127,0.029533023,-0.018652072,0.0519375,0.015182178,-0.035892237,-0.07978176,-0.08685137,-0.05254371,-0.018527433,-0.009959755,-0.050655387,0.044630602,-0.04582671,-0.05769286,-0.028810224,0.02005189,-0.011423452,-0.01533025,-0.05109499,0.013783603,0.024408981,0.07350861,0.03605774,0.05620942,-0.094672844,-0.077006295,-0.014881268,-0.054149494,0.024060057,-0.0012963669,-0.07774693,0.07637869,0.043407433,-0.15565886,-0.0071670897,-0.022054207,-0.07276885,0.03123097,0.22301146,0.034189504 +4.2.3.22,"Requires Mg2+ for activity. H-1si of farnesyl diphosphate is lost in the formation of (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol. Formation of (-)-germacrene D involves a stereospecific 1,3-hydride shift of H-1si of farnesyl diphosphate. Both products are formed from a common intermediate [2]. Other enzymes produce germacrene D as the sole product using a different mechanism. The enzyme mediates a key step in the biosynthesis of geosmin (see EC 4.1.99.16 geosmin synthase), a widely occurring metabolite of many streptomycetes, bacteria and fungi [2]. Also catalyses the reaction of EC 4.2.3.75, (-)-germacrene D synthase.",384,0.99999994,-0.09185121,-0.014691758,-0.024405757,-0.058068156,0.051420595,-0.033131734,0.033956945,0.056290954,0.022046136,0.00811978,-0.025548618,0.01098022,-0.02372658,0.032060936,-0.04933964,-0.04844644,-0.055740573,0.03206161,-0.020635368,0.02177833,0.103704385,0.03331907,0.04186094,0.028916147,0.04434092,-0.019839756,0.1168457,-0.033244826,-0.0029067623,-0.030250331,-0.0051271934,-0.030882278,-0.0039927084,-0.058170743,0.025741266,0.12849696,0.023855252,-0.035718244,-0.0034233332,0.067797326,0.053863414,-0.019368239,0.060865268,-0.009218811,-0.061050024,-0.047919035,-0.0005497817,0.01620289,-0.007838615,-0.0065631093,-0.060733665,-0.08246258,-0.04819738,-0.013094149,0.05823317,-0.0402708,-0.017090203,0.009085781,-0.0074854903,-0.02340565,0.022947807,-0.046011485,0.010447813,-0.10344507,0.035335388,-0.023309205,0.055426545,-0.09131737,0.0371879,-0.030258015,-0.057528026,-0.0023309628,-0.04426818,0.023179246,-0.04235751,0.067998275,-0.016709346,0.0021732284,0.009089773,-0.06200135,0.08006539,0.0629169,0.070346795,0.06369488,0.024118459,-0.003895633,-0.013447342,0.09808734,0.08110896,0.0039215116,0.0372298,0.0016900923,-0.0050397557,-0.026140034,-0.056461487,0.023486882,-0.010440516,0.01843627,0.054290608,-0.01896988,0.023010718,0.05792605,-0.039291453,-0.0050176815,-0.024590181,0.019468853,-0.07125792,0.1277514,0.0077078245,-0.007914932,-0.031117512,0.05514034,0.05715393,0.043217424,-0.11240478,0.076851085,0.04173111,-0.03784648,-0.051661912,-0.021073965,-0.006410985,0.021778086,0.053990733,0.057485674,0.006379968,0.025150249,-0.12932213,3.8609883e-33,0.1156035,0.021949243,0.04777765,0.040483378,-0.12323611,0.077376604,-0.13139722,0.019157974,-0.005613143,-0.026942404,-0.08460655,-0.088261165,0.049496826,0.005331923,-0.029098151,-0.0060111354,0.03817204,-0.015801227,0.059752915,-0.048754532,-0.029056106,0.07239464,-0.047418773,0.004161851,0.025678396,0.10919744,-0.01807623,0.047542837,0.022268476,-0.026491253,0.038525615,-0.12445849,-0.042911153,0.04761521,0.061552104,-0.009683543,-0.025064953,-0.01031464,0.048888355,-0.035682455,-0.033508267,-0.0006806264,-0.03795863,-0.047973633,0.08247592,-0.033633962,0.0060600094,0.07456506,0.09344376,0.0326233,0.03580653,0.010366377,0.03770885,0.030869966,-0.12819503,0.0036346258,-0.023231998,-0.04197034,0.13785265,0.036549717,0.019223033,0.07520969,0.005540861,0.05255913,0.056210577,-0.019298738,-0.08264269,-0.05175933,-0.06239025,0.15495914,0.001522988,-0.07501243,0.008630595,0.07793609,-0.022627257,-0.042316426,-0.024025833,-0.041471653,0.011916884,0.047124773,0.029133823,0.0136092715,-0.035849728,-0.048257176,-0.08301961,0.018632336,-0.041693613,-0.07966961,-0.048786514,0.08373073,-0.045826733,-0.076927245,-0.06331546,-0.031002106,-0.023134239,-4.3244083e-33,0.032623705,-0.058167487,-0.0009219857,-0.06562886,-0.054256957,0.016325511,0.0075575355,-0.054879952,-0.019034268,-0.05130866,0.06385534,0.017001383,0.04427842,-0.0010364559,-0.021748584,-0.026020695,-0.023002744,0.05432324,0.016172258,0.013461674,0.010211075,0.0585418,-0.045362223,0.017260155,0.03056376,0.026167842,0.042690717,0.08686892,-0.0069976314,0.14173386,-0.0090442635,0.045214623,-0.043817464,-0.03064965,-0.04555563,0.035318073,-0.0927286,0.005893114,0.04679888,0.00022253372,-0.05768129,-0.0356985,0.12310705,0.047073796,0.08871911,0.0779982,-0.019641353,0.041314527,-0.016688574,-0.01901874,-0.030764418,0.04356197,0.00080026727,-0.042258617,0.016306022,-0.010512695,0.022324365,-0.024212437,-0.0032941804,-0.03170591,0.039902665,-0.009589237,0.07105693,-0.06901667,0.0068393378,0.06937423,0.028759263,0.07963547,0.08300183,0.028423097,0.07917179,0.025665281,0.06136108,-0.0055396003,-0.037986547,0.04151961,-0.073763475,0.054711513,0.016794257,-0.052840993,0.033154532,0.04094217,0.019738229,-0.062732205,-0.044949103,-0.03855819,0.053385187,0.11265485,0.019402841,0.02181728,-0.088764116,-0.018436009,-0.03359324,0.07194115,0.040615305,-4.836282e-08,-0.030404387,-0.040058848,0.072347164,-0.025785346,-0.022980876,0.02349358,0.005715097,-0.0057807616,0.04008898,-0.027566634,-0.042663936,0.062350538,-0.009287049,-0.042684928,0.018028956,-0.02203778,-0.09264783,0.03458176,-0.070803866,0.0018582419,-0.0043632532,-0.0093769785,-0.08881304,-0.001581095,-0.020166988,-0.12456607,0.052536953,0.03761383,0.013101283,-0.08815896,0.063193254,-0.02671772,0.030998582,-0.010151538,-0.068608515,0.0023763042,-0.08920721,0.030716047,0.014674738,-0.05522499,-0.050453488,-0.008338095,-0.03418616,0.037852082,-0.117953636,-0.014739514,0.015488589,0.018426524,-0.04984611,0.035453565,0.027084548,-0.012196301,-0.051224265,-0.052383933,-0.07482056,0.03153723,-0.016902464,-0.031661384,-0.015656324,-0.06317877,-0.047635525,-0.04715034,0.06979062,0.0054457057 +4.2.3.24,"Requires Mg2+ and Mn2+ for activity. This is a key enzyme in the biosynthesis of the antimalarial endoperoxide artemisinin [3]. Catalyses the formation of both olefinic [e.g. amorpha-4,11-diene, amorpha-4,7(11)-diene, gamma-humulene and beta-sesquiphellandrene] and oxygenated (e.g. amorpha-4-en-7-ol) sesquiterpenes, with amorpha-4,11-diene being the major product. When geranyl diphosphate is used as a substrate, no monoterpenes are produced [2].",384,0.99999994,-0.024755005,-0.047554832,0.011709408,-0.002334925,0.08940068,-0.013292697,-0.052931413,0.035970613,0.066616595,0.028350567,0.053970672,0.019237181,-0.037265062,-0.033597365,-0.045612793,0.060211577,-0.066827714,0.013446609,-0.008884754,0.05115972,0.10461281,0.0029361069,0.012695926,-0.034114815,0.06624898,0.08085441,-0.013931854,-0.026782986,0.036838934,0.013625973,0.0073502054,0.0025858416,0.046753623,-0.06701027,-0.07629224,0.07701424,-0.023782918,0.0048886333,0.03915618,-0.031447917,0.036919903,-0.06329449,0.020144062,-0.077008255,-0.015150733,-0.11201138,-0.006435069,-0.053045202,0.05859133,0.06567215,-0.04685433,-0.048756357,-0.08924244,0.041112192,0.050799396,-0.049342327,-0.066364385,0.004687881,-0.06617449,0.04776053,0.06525825,0.00092561997,-0.052054092,-0.012622857,-0.06755462,-0.023725012,-0.029598385,-0.003821599,-0.02021139,0.012392499,-0.008250931,-0.055793446,-0.07015188,-0.022877902,-0.08699301,0.094285905,0.06373825,-0.020731281,0.036936313,-0.029238185,0.012472557,0.016861938,0.088757895,0.12659821,0.056082416,0.044941816,-0.020384222,0.07378513,0.06794853,0.036121543,0.016015142,0.04862538,-0.030062864,0.0041445396,0.0047270274,0.070051074,0.02228537,0.044856835,-0.0412097,0.009177114,-0.015280945,0.035002228,-0.11617449,-0.0915827,-0.074440375,0.017467499,-0.022549631,0.0046872986,0.018550428,-0.03432573,0.057212926,-0.063748226,-0.00067531515,-0.009926267,-0.09838897,0.053696495,-0.03370926,-0.066744074,-0.053928442,-0.0049835336,-0.003563624,0.022159152,0.019461269,0.0409403,0.012097774,-0.012446413,0.002473064,2.2566564e-33,0.024829188,0.0040191147,0.025056023,0.01962313,-0.049063426,0.04074683,-0.023068734,0.12196913,-0.0035428193,-0.05282325,-0.08902766,-0.055258963,-0.035081796,0.059878487,0.05369819,-0.04381375,0.062885076,-0.022912364,0.11369192,-0.01753179,-0.016679034,-0.009905275,-0.04565059,-0.04981983,-0.0066151833,0.014403202,-0.026646586,-0.017073203,0.05399931,0.0014535624,0.027683107,-0.115403116,-0.023593308,0.013013229,0.03763153,0.022883276,-0.08152677,-0.02040207,-0.063478656,-0.012946829,-0.035294443,0.086503044,-0.046557587,0.04416535,0.010472042,-0.03127849,-0.019220507,0.06158576,0.10313159,0.032945476,-0.004504359,0.026711665,0.04933408,0.053319614,-0.05988572,0.06358505,-0.021111552,0.031314716,0.025033308,0.027970152,-0.038348608,-0.0069160853,0.0031940883,0.032712888,0.024437897,0.053886745,-0.07008772,-0.054781344,-0.022043403,0.04517485,0.027431117,-0.037395675,0.008833548,0.045266595,0.03353653,0.020228593,-0.01327207,-0.014964611,0.103170566,-0.014091196,0.033552002,-0.045046717,0.005547999,-0.052814297,-0.094928406,0.02003368,-0.050002016,-0.0036167158,0.03208175,0.038284976,0.019870266,-0.07202702,-0.089944415,0.001394348,-0.07019823,-3.910238e-33,0.029513342,-0.102589846,-0.002047248,-0.06997042,-0.108271554,0.10368496,-0.022707138,-0.042383485,-0.0032872958,0.04618844,0.112591416,0.017725676,0.022399073,0.00031293233,-0.053341176,-0.059670016,0.016904013,0.09912595,0.044903506,-0.029587628,0.031595107,0.12803453,0.03696932,0.065534696,0.009572706,0.007874521,-0.0014149792,0.0060500386,-0.067868076,0.112123065,0.034199905,-0.026808025,-0.029141724,-0.03274918,0.0019316114,0.051723305,-0.0080328435,-0.004255069,0.029197844,0.08634901,0.015060931,-0.041556187,0.050084986,0.057836078,0.06856892,-0.06792583,-0.17335753,0.09671114,0.017122567,-0.09075176,-0.005715689,-0.001234847,-0.028574534,-0.025014553,0.042261984,-0.040172942,-0.01065401,-0.05571733,0.051395535,-0.10376193,0.0069125607,-0.05840311,-0.01053448,-0.04963881,0.047666,0.09298126,-0.0086057,0.023108762,-0.013300839,-0.005757475,0.00077075633,-0.026835538,-0.0024876713,0.0055191475,-0.023543788,-0.013886073,0.030929958,-0.1298831,0.024523966,-0.052250978,0.0009496164,0.0003842698,0.03994353,-0.06214459,-0.07616411,-0.08821837,0.0375199,0.08852532,-0.046864294,0.0710443,-0.047771394,0.026818788,-0.006127589,0.057808116,0.04865991,-4.5563898e-08,-0.012211356,-0.0060219415,0.118535295,-0.013924661,-0.06373025,-0.0122181345,0.002339248,-0.02313368,0.12387229,0.00012156619,0.004987371,0.04736548,-8.786079e-05,-0.011903558,0.05658489,-0.054489095,0.079157844,0.03569232,-0.044268582,-0.058169223,0.008935597,-0.03220319,-0.053511526,-0.054281056,0.036857974,-0.1472934,0.005092035,0.025736038,0.029335827,-0.028206393,-0.0036507435,0.013674533,0.03152539,0.029358389,-0.0929255,0.042082176,-0.01031716,-0.043753035,-0.030891713,0.009057449,-0.08095517,-0.05511257,-0.014189509,-0.00056194555,0.01872648,0.012739903,0.08060119,0.036009196,-0.0025701104,0.007565068,0.042449538,-0.03141968,0.03272411,-0.06321238,-0.07884637,-0.07754249,-0.04784393,0.068645075,0.005195307,-0.07250045,-0.01225784,0.014471996,0.10047939,0.0005197637 +4.2.3.25," Requires Mn2+ or Mg2+ for activity. Neither (S)- nor (R)-linalyl diphosphate can act as substrate for the enzyme from the flower Clarkia breweri [1]. Unlike many other monoterpene synthases, only a single product, (3S)-linalool, is formed.",384,1.0,-0.06742775,-0.1082955,-0.10545678,0.018804563,0.027758088,0.007122093,-0.066301435,-0.07651058,0.017418122,-0.0007776775,0.016970199,-0.016076813,0.05105431,-0.0052647954,-0.018420976,0.017180545,-0.035643253,0.022203667,-0.007992979,0.01745111,0.09113694,-0.016569166,-0.020630242,0.007649067,0.03628892,0.0712294,-0.006529484,-0.038778033,0.036310617,-0.072483495,-0.035006873,0.07510703,0.05231489,-0.136097,0.027884962,0.07802313,-0.03621188,-0.018083883,0.010662181,-0.019495727,0.085998036,-0.03808635,0.08290361,-0.064845465,-0.03904192,-0.048915543,0.01620256,-0.057595227,0.03715473,0.017991807,-0.050724786,-0.083944045,-0.021133622,-0.023969462,-0.029811587,-0.063204326,-0.012859661,0.066584505,-0.05697771,0.013468304,-0.0065400456,-0.011306034,-0.015687788,0.031178089,0.0038248282,-0.031347968,-0.10765051,-0.022393387,0.036946904,-0.036504842,-0.07069954,-0.06472431,-0.06298701,-0.03641353,-0.023830831,0.08019334,0.103503816,0.023805875,0.065805435,0.0012277467,-0.011975241,-0.0005929505,0.028450826,0.11078547,0.052384425,0.09617044,-0.030109197,0.016479675,0.053704493,0.022750081,0.03973902,0.017743984,-0.02095191,-0.019511852,-0.05442125,0.06702633,0.0012277508,-0.014387079,-0.05095337,-0.0031802265,0.013182252,0.049711946,-0.05856391,-0.010547198,-0.021180294,0.015520382,-0.06845547,0.011951845,-0.0050665564,0.0043064174,0.061750136,-0.017367644,0.0071714623,0.030727679,-0.049048603,-0.004923757,0.013613528,-0.11493625,0.00050217233,-0.012570038,-0.02753902,-0.017655497,-0.0046224035,0.0280855,-0.02710743,0.006665395,-0.07433367,1.3977382e-33,0.05919515,0.083423555,0.0037735482,0.0025832737,-0.06866336,-0.0040715015,-0.0020531435,-0.010991146,-0.047119565,-0.07155882,-0.06324247,-0.052437708,0.07163675,0.07557558,0.034065668,0.002337375,0.08214672,-0.011982294,0.081541054,0.014355813,0.03608863,0.025721807,-0.104078464,-0.052198954,0.009386789,0.037357602,0.034790896,-0.08686629,0.029803269,-0.039327975,0.037131097,-0.0821429,-0.00496535,0.067577444,0.059998,-0.042481963,-0.005320435,-0.046062842,-0.037530027,-0.0072262874,-0.027865319,0.05197911,-0.03860233,0.03843855,0.049936514,-0.057079025,-0.062612504,0.018797047,-0.0033338622,0.047332436,0.020619597,0.04879983,0.1273658,0.04938696,-0.05329046,0.053844865,0.02813787,0.027679501,0.0741024,-0.0032075776,-0.067002535,0.049020037,-0.030853555,0.008855019,0.034947205,0.08288142,-0.09772496,-0.07237741,-0.0063477904,0.10797301,0.030593429,-0.04555758,0.001049268,0.036077786,0.07186626,0.011898393,-0.0077914116,0.011859774,0.096464016,0.06134831,0.05780379,-0.031142464,-0.014365744,-0.0051514283,-0.11230719,-0.060209155,0.019830715,-0.03840846,-0.013782856,0.019362539,0.084855966,-0.010442469,-0.018853026,0.018497173,-0.031502314,-2.3775321e-33,0.06511594,-0.053417757,0.06188455,-0.08574167,-0.111607246,0.0122262845,-0.011596841,-0.14991608,0.07494853,0.017041251,0.06205808,0.019773241,0.022276057,0.02320139,-0.04831265,-0.005154152,0.04281216,0.07998275,0.020651586,-0.031064523,-0.03416939,0.12939917,0.03680778,0.042964734,0.008080116,-0.05966722,0.01107563,0.04586398,-0.025790416,0.051344264,-0.017140314,-0.008270848,0.005777115,-0.0039773984,-0.027237494,0.06484632,-0.053322405,0.022384254,0.01296068,0.06521402,-0.0067758476,-0.004220404,0.040943746,0.09119159,0.058105018,-0.045056794,-0.114775434,0.07596539,0.025018401,-0.022255143,-0.03165405,-0.0034312664,-0.044300564,0.017887866,0.06728034,-0.006613115,0.036170766,-0.016355284,0.028824478,-0.11560415,-0.012704514,-0.053472918,-0.04115426,-0.043787878,0.02787273,0.12724535,0.0035434335,0.0064385585,0.025998536,0.017517533,0.06656915,0.06595813,0.10196537,0.012034136,0.013942777,0.0025725148,-0.05159145,-0.04746646,0.020320319,-0.10013098,-0.005264334,0.05331785,0.0056891493,-0.080366656,-0.015380172,-0.07903184,0.043259878,0.0341362,-0.005609128,-0.01198601,0.0036736943,-0.033571027,-0.015757207,0.08759127,0.123461686,-3.843393e-08,0.010132997,-0.018743409,-0.010033571,-0.04654176,-0.048078787,0.04929834,0.025837166,-0.12745807,0.10484017,0.06962802,-0.012667533,-0.0036842783,-0.012485223,-0.02252225,0.12447222,-0.0015780182,0.0737646,0.0066601685,-0.04993803,-0.025822444,0.027329924,-0.0074049653,-0.07990893,0.0005622533,0.0049386336,-0.09681966,-0.0016495683,-0.006497956,-0.021000104,-0.06446035,0.018810643,0.050840996,0.015187456,-0.00048595635,-0.07350212,0.0027158824,0.006052643,0.002835234,-0.03888149,0.03273218,-0.07585116,-0.04581253,-0.012745226,-0.0075133583,-0.04349945,0.0053925226,0.010107246,-0.039428655,0.0113853635,-0.029720722,0.01401544,-0.014824022,0.043032207,-0.08960707,-0.057251208,0.022699555,-0.013768257,-0.0037929781,-0.03285542,-0.030720148,0.006589065,0.009895819,0.1856628,-0.06680335 +4.2.3.26,"Geranyl diphosphate cannot be replaced by isopentenyl diphosphate (3-methylbut-3-en-1-yl diphosphate), prenyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate [1]. Requires Mg2+ or Mn2+ for activity. Unlike many other monoterpene synthases, only a single product, (3R)-linalool, is formed.",384,1.0,-0.035370667,-0.07738538,-0.025747288,-0.039447665,-0.027826536,-0.025399521,-0.061712265,0.0021191675,0.031031432,-0.028129786,0.048778363,-0.0022223417,0.019290866,0.010234237,0.043241337,-0.04181027,2.1520766e-05,0.050996184,0.06630396,-0.0024704225,0.051951002,0.016087344,-0.04779402,-0.023225702,0.058197666,-0.012475355,0.017629134,-0.044800624,0.044673383,-0.067777485,-0.0696995,0.026901202,0.030469516,-0.1259931,0.05550871,0.059351996,-0.075966485,-0.0027855108,0.0060973335,0.014378484,0.08726943,-0.040179286,0.08857443,-0.059796393,-0.03891917,-0.036582176,-0.0015230384,-0.082924716,0.0076761846,0.011872764,-0.028800141,-0.077146,-0.010515294,-0.038204033,0.03810192,-0.13036504,-0.011027989,0.028983288,-0.03403319,0.045134608,0.01277065,0.043345388,-0.061380778,-0.0982454,-0.0013187963,-0.0037041719,0.042984147,-0.015059403,0.04813566,0.00053939404,-0.120460205,-0.03753915,-0.066986285,-0.0013374701,-0.08459839,0.07674178,0.032208364,0.06523131,0.053713974,0.0014578922,0.023999784,0.017230486,0.0059368988,0.02486352,0.080958225,0.05185864,-0.09721889,0.07285534,0.062333245,0.008933553,0.012779494,0.04487367,-0.0076333513,-0.03452884,-0.08397029,0.107505225,-0.04337696,0.04315773,-0.033585746,0.0013317582,0.07135627,0.024427693,-0.06444618,-0.024837794,-0.03258399,0.03816007,-0.05018681,0.01450226,-0.016706318,-0.008250702,-0.008353399,0.014638223,0.012738497,0.0010351824,-0.057984654,0.007807891,0.03552109,-0.08283657,-0.014376638,0.032034684,0.013032026,0.005059317,0.048221573,0.041205876,-0.014709433,-0.019289732,0.014799817,7.5933864e-33,0.010405324,0.10294453,0.033582702,0.018468728,-0.12052942,0.055767737,-0.021906903,0.029606085,-0.029232757,-0.05660713,0.012690463,-0.082237825,0.023857364,0.059592586,-0.033594776,-0.014238185,0.04339532,0.038210317,0.13213158,-0.09416314,-0.032050185,0.044641607,-0.06742271,-0.04476765,0.019052027,0.059315354,-0.029360155,-0.080399886,0.05820258,-0.02997141,0.07858979,-0.09290146,-0.017373437,0.048250306,-0.050543487,-0.1192809,-0.027460387,-0.053321052,-0.050009657,-0.022648424,-0.009532039,0.05683661,-0.033165388,0.03676415,0.10151778,-0.03207071,0.008862183,0.03869224,-0.00952081,-0.013639683,0.034731794,0.03550873,-0.01677221,0.007494578,-0.06571142,0.053525712,0.029839607,0.025489507,0.06833716,0.01150954,-0.009641835,0.06672783,-0.040089905,-0.011591799,0.07574263,0.0513042,-0.065092996,-0.05108238,-0.024935627,0.17303282,0.036826003,-0.12127314,-0.005043854,0.10548251,-0.030774444,-0.023055006,-0.06669174,0.008891674,0.0638869,0.0005037743,0.054629974,-0.004461242,-0.004181464,-0.021020403,-0.05393684,-0.022631787,0.036512684,-0.040563043,0.015347932,0.07239795,0.06288919,-0.033562988,-0.04346974,0.040933244,-0.034685906,-7.09676e-33,0.100941785,-0.054002378,0.006820263,-0.09324477,-0.096921705,-0.01080354,0.07286531,-0.07421341,0.0061328975,0.009174611,0.04615025,-0.040015288,0.071347095,-0.024274457,-0.077423364,-0.004064416,-0.012745685,0.05039455,0.0079830745,-0.025801523,0.010736262,0.10995584,0.08191819,0.10147921,-0.023595173,-0.044456597,0.07531024,0.029288342,-0.019430622,0.12800865,-0.05112381,-0.008068466,-0.006944471,-0.025177883,-0.050602175,0.039178465,-0.014255671,0.05404539,-0.016652515,0.024842711,-0.04957309,0.02655651,0.051716436,0.0024189572,0.040229034,0.05042969,-0.062313017,-0.004844911,0.053036693,-0.056833353,-0.023665097,0.010657231,-0.014997776,-0.019295907,0.04108652,-0.035501,-0.015360027,-0.07634679,0.044075765,-0.12015064,-0.058751166,-0.016800888,0.015725568,-0.09527894,0.11259918,0.13947149,0.013163376,0.03548227,0.007194872,0.026008306,0.05625533,0.05649779,0.056421768,-0.0481612,-0.01290129,0.035865873,-0.023500346,-0.0077951597,0.0072624856,-0.11368307,0.033322133,0.011895755,-0.027324228,-0.07443011,-0.044681422,-0.04549947,0.041990235,0.11271401,0.06163201,0.014651549,-0.03901838,0.038846843,-0.014471125,0.061936967,0.106264316,-4.6165187e-08,-0.014095408,0.010628357,0.02591084,0.0066516423,-0.043183953,0.041472428,-0.0529983,-0.036174648,0.060056705,0.083282426,-0.01949298,0.012342377,0.012368873,0.023208965,0.071068734,-0.01759184,-0.011718924,0.032454938,-0.033092987,-0.061387617,0.009807161,0.037469022,-0.01750849,0.014722878,0.0294119,-0.098159716,-0.009063368,0.013422446,0.056016106,-0.054535273,0.019116921,0.007051319,0.028689064,0.027804283,-0.008903869,-0.0061163763,-0.04953423,0.01532778,-0.039409924,0.00953334,-0.06525457,-0.032797642,-0.095240064,0.02334827,-0.067061566,-0.017035127,0.019813346,-0.015726011,-0.018151833,-0.011397604,0.0680489,-0.016324561,0.01766713,-0.058343336,-0.01703774,-0.017549679,-0.04715166,0.016645616,-0.029779099,-0.036817823,0.010105127,-0.044611182,0.13654499,0.01670919 +4.4.1.24,Requires iron(II). This inducible enzyme participates in cysteate degradation by the bacterium Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation by the bacterium Chromohalobacter salexigens. The enzyme is specific for the (R) isomer of its substrate.,384,1.0,-0.04669606,-0.031901203,-0.09840492,0.025336804,0.045524053,0.019358767,-0.033674397,0.070796,-0.011803686,-0.053561192,-0.06593553,-0.0147308195,-0.0027849262,0.035202645,-0.049370207,-0.033907562,-0.036467083,0.026372956,-0.00063298113,-0.025429226,0.07272622,0.009509431,-0.045010053,-0.037030708,-0.023959117,0.043642126,0.01489454,-0.021597734,-0.03079391,-0.0036450054,-0.011590108,-0.037030533,0.076325394,-0.035111822,0.100081444,0.029822119,-0.023590162,-0.059593547,0.059133157,-0.032521132,0.017321367,0.046440948,-0.044280138,-0.025742922,0.021509053,0.0018079194,0.03746013,-0.016496444,-0.020415887,-0.006813089,-0.075552784,-0.01113468,-0.031210825,0.10125811,0.0010462718,-0.014937838,-0.044281796,-0.052945524,-0.0296322,-0.028851146,-0.006194307,-0.05096666,-0.049650494,-0.0075686276,-0.0075535635,-0.061556738,0.060357355,-0.05654267,-0.030022873,0.025623616,-0.12424816,-0.03891099,-0.09809558,0.034182724,-0.00040616115,0.08449411,0.07127895,-0.097804554,0.0014764622,-0.059519008,-0.0029306826,0.005529336,-0.010524032,0.08645568,0.024280276,-0.0011715214,0.020351075,-0.073422514,0.018913418,0.05738843,0.079477936,0.072666824,0.01623873,-0.06645032,-0.040283643,0.049824532,0.0030164425,0.030526739,0.04386731,0.0072442354,-0.00025381197,0.049027428,-0.035545126,-0.074648365,-0.05328908,0.005609784,-0.02589466,0.130569,0.052904412,0.08813423,-0.002781229,0.0025524131,-0.0055975528,-0.050251357,0.024970906,0.08959074,0.121342696,-0.029026473,-0.069403134,-0.010208214,0.041051082,-0.03094667,-0.009010898,0.045309532,-0.025173489,-0.024287459,-0.07424856,3.2667947e-33,0.04184559,0.016471907,0.040207777,-0.03634731,-0.083443716,-0.016500108,-0.09038536,-0.02144387,-0.019013368,0.0061375266,-0.06368001,-0.11080972,0.010450136,-0.0162265,-0.046214476,0.06387492,0.013934727,0.0027420658,0.054719355,0.024718167,0.04505431,0.049654637,0.035604086,-0.035821047,0.052230176,0.072072394,0.007657824,0.015285569,-0.040688388,-0.014230502,0.12601918,-0.086183384,-0.1375177,-0.0022720767,0.10239796,-0.008160802,-0.007282286,0.00058291724,-0.022285735,0.09209532,0.008726475,0.007906382,0.037114818,0.029541792,0.09001217,-0.09895827,-0.017756736,0.12774472,0.007698871,0.07181581,0.0035565908,-0.04120967,0.09886395,0.005994523,-0.011363083,0.03611982,0.030075282,-0.036747873,0.037599508,0.041050974,0.007085114,0.050399806,-0.03891735,0.045525838,0.05227465,-0.019690635,-0.09424188,0.029992126,-0.02767397,0.059277434,-0.10727004,-0.0047251093,0.012906646,0.049359843,0.0282431,-0.12004691,-0.098924465,-0.00023525971,0.08757129,0.0005530015,-0.01289655,-0.060610116,0.012117322,-0.02741339,-0.095646285,-0.04261429,-0.015550864,-0.012125687,0.0074828407,-0.03298243,0.071991414,-0.057354122,-0.08393965,0.058841217,-0.019203981,-4.8192168e-33,0.07282556,-0.03846043,0.018446855,-0.008207324,-0.09308289,-0.0034557462,-0.02134227,-0.011075562,-0.008586148,0.003028408,0.06728047,-0.024798132,0.051637612,-0.035560336,0.0018788379,0.023834221,0.0049929027,0.06677498,-0.025023289,-0.049861237,-0.062053215,0.09244729,0.010638694,-0.009187669,-0.003190118,0.023093883,-0.052387692,0.07149578,0.08571136,0.07372415,0.007773113,0.030437656,-0.018406583,-0.12131659,-0.011914291,0.025088351,-0.013539844,0.025377972,0.05720977,-0.0011839307,0.009534546,0.022075895,0.060153592,0.10585537,0.0289968,0.034277458,-0.056204543,0.04611809,0.063374594,0.031978138,0.017274324,-0.033672065,-0.033119205,0.032530237,0.06684526,0.048601653,-0.003991029,0.04861531,-0.018574467,0.00858411,-0.031127822,-0.01801488,0.0805972,0.0015576639,0.08736585,0.03799317,-0.0074502705,0.11078169,0.018542571,-0.0038410774,-0.003349783,0.036796875,0.015799154,-0.10995094,-0.062491495,-0.017096989,-0.0775524,0.06654878,-0.01962664,0.0568135,0.034110904,-0.02064224,-0.028371915,-0.06710742,-0.021682834,-0.078558624,-0.029342402,0.05515024,-0.050252207,-0.066055566,-0.07198275,-0.074205644,-0.004671593,0.03839437,-0.014393011,-3.9232816e-08,-0.004945264,-0.058153745,-0.040812846,-0.059731565,-0.018928373,0.034446247,0.003827228,-0.0671374,0.04297317,0.01103106,-0.02943139,0.10041262,0.02161451,-0.017890822,0.036971793,0.03159558,-0.06686252,-0.008832877,-0.017700097,0.040337905,-0.07103007,-0.07741544,-0.10027468,0.04911293,0.08681133,-0.046711013,0.0863117,0.012004345,-0.00722751,0.003409007,-0.0055014747,0.051673207,0.020262007,0.032283988,-0.082680434,-0.011310326,-0.048788164,-0.025290363,0.0004840083,0.037761386,-0.002405017,0.032902017,-0.15299805,0.0068655466,-0.0041753976,0.0061961277,0.006930143,0.044460185,-0.07538375,-0.063902356,0.005382549,-0.036174,-0.018604888,-0.024869364,-0.031478673,0.057505336,0.08315485,-0.033028424,0.04915555,0.00454635,0.0017345729,-0.05215739,0.14362906,-0.05519691 +4.4.1.25," A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogensulfite and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. D-Cysteine can also act as a substrate, but more slowly. It is converted into hydrogen sulfide, pyruvate, and ammonia. This inducible enzyme from the marine bacterium Silicibacter pomeroyi DSS-3 forms part of the cysteate-degradation pathway.",384,1.0,-0.0707364,-0.018209446,-0.035900645,-0.079919904,0.0656966,0.025591608,0.0004054647,0.034001626,0.063548855,0.02966158,0.018401166,-0.008742509,-0.07461704,0.07648211,-0.019946704,0.073952444,-0.06646415,0.04434822,0.030861393,0.0039776685,0.094705805,0.042536855,-0.06676682,0.014056338,0.033725653,0.07156868,0.039525293,0.015801778,-0.038850967,-0.047820825,-0.077567115,-0.08291502,0.07176455,-0.068158306,0.12180828,0.10986579,-0.041889716,-0.0231405,0.024506545,-0.014727433,0.02968868,0.012086141,-0.025180116,0.031020004,-0.030159637,0.011491119,0.036550857,0.029919172,0.0038923873,-0.09388214,-0.08075433,0.0023511956,0.003578395,0.0059534903,0.007229111,0.0022705526,-0.027388247,0.03355203,-0.048993733,-0.072118655,0.042734552,0.03096094,0.013998854,-0.060395803,0.034204558,-0.049282003,0.05770442,-0.061104484,0.019400721,-0.0041759564,-0.105811805,-0.046174064,-0.05506311,0.0396934,0.015546562,0.067331314,-0.014155198,-0.026494225,0.0077335914,-0.006164666,0.025050327,0.021520557,0.01646853,0.03041245,0.03749482,-0.052802276,-0.020158408,-0.0015328333,0.031359557,-0.011586362,-0.059997644,0.014055714,0.014939281,0.008466163,-0.01939947,0.013845005,-0.0067133904,0.04956193,0.07738855,-0.03791237,0.00031122527,0.11241252,-0.07865183,-0.09054019,-0.045862816,-0.0034435748,0.011999708,0.13620761,0.037867766,0.012840077,-0.09132996,0.026396386,0.021071807,0.04362207,0.0034843355,0.097029455,0.07055014,0.025561031,-0.04946719,0.015613512,0.021414412,-0.008473529,0.01448516,0.09435751,-0.078075916,0.019903993,-0.1463583,2.145191e-33,0.06295586,-0.0047156094,0.034827124,0.035416562,-0.03960491,-0.065742195,-0.10355072,-0.0017945112,-0.0063498686,-0.05139486,-0.0735276,-0.088795684,0.039440446,0.025167488,-0.03262434,-0.05498051,-0.03435263,0.050334822,0.10151441,0.0077014985,0.044674803,0.04504071,-0.041235186,-0.013822387,0.06240108,0.073057584,0.047169663,0.024726864,0.038384646,-0.032028545,0.022006197,-0.15146844,-0.12312485,-0.020652652,0.06750793,-0.06972081,-0.036229346,0.009670479,-0.023057982,0.044762015,-0.07728305,-0.020627411,-0.008041175,-0.04280404,0.036708646,-0.05570428,0.0069082733,0.06511911,0.0064246794,0.00026331787,0.07035281,-0.053665716,0.04906413,0.019442704,-0.09531449,-0.019382566,0.03886351,-0.017783169,0.00013363893,0.037988715,0.0334229,0.052683737,-0.044864222,0.020366663,-0.008506833,-0.011389607,-0.034191675,-0.035910532,-0.0056825965,0.13052362,-0.09603132,0.0012600225,0.022039358,0.020899877,-0.0259582,-0.08384559,-0.115980335,0.0029004181,0.037490882,0.04073924,-0.033831943,-0.04309218,-0.017572576,-0.015574524,-0.0431371,-0.037947297,-0.012680326,-0.029192638,-0.0014874482,0.060118783,-0.02991851,-0.117019996,-0.011448047,0.0347311,-0.02596654,-3.1801677e-33,0.0886049,-0.027495489,0.038268022,-0.07529166,-0.06061282,0.051126897,0.022711676,0.060276356,-0.00016229157,-0.049483374,-0.0046209847,-0.016208263,0.04789909,0.02403671,-0.009242648,0.026864924,-0.010230501,0.031918373,-0.036552113,-0.00058906426,0.006400794,0.06922543,0.0030077093,0.017453505,0.021287048,0.051653273,0.037877094,0.07035856,-0.009559712,0.077527404,-0.0065775476,0.03887485,-0.050298765,-0.084824964,-0.09431237,0.07959825,-0.07977048,-0.04617347,-0.008180908,0.012236053,0.007612204,0.033099387,0.03606816,0.06457515,-0.015195462,0.09351236,-0.01490424,0.042119537,0.02233385,0.036043677,0.047013745,0.022343945,0.037998393,0.0044858665,0.028073175,0.017345954,-0.0072072875,0.027333774,-0.02609902,0.034187526,-0.02365369,-0.08233223,0.008460319,-0.018537689,0.0313459,0.04290666,0.005619835,0.0691709,0.0351225,0.023045495,0.07156384,0.029116187,-0.0016848693,0.03614743,-0.011712179,-0.039046142,-0.0859301,0.043073237,0.0479965,-0.011472449,-0.0019666085,-0.023870014,-0.008362813,-0.07609448,0.022123933,-0.092934705,0.031793352,0.0992888,-0.01202387,0.022243196,0.003918519,-0.0480551,-0.012116313,0.1144549,0.020940872,-4.3113534e-08,0.064115115,-0.077960715,0.018436417,-0.014559446,-0.0614651,0.010285769,0.038292963,0.035078004,0.06539293,-0.05573729,0.010334746,0.012608993,0.0027799113,-0.029934196,0.034738168,0.0042609423,-0.018833838,0.02560487,0.0021019927,-0.029214561,-0.053863157,-0.012133175,-0.17590052,0.071824886,0.07029178,-0.032288093,0.06841392,0.013050383,-0.020107327,0.018451598,0.046400104,0.047861863,0.004701707,-0.0034235662,-0.05231631,0.013462673,-0.08588417,-0.06735641,-0.011410838,-0.009127399,-0.021081042,0.05905825,-0.12807865,0.009964339,0.011117954,0.042385478,-0.057490934,0.036984485,-0.04562047,-0.024847597,0.05468374,-0.03144048,-0.0055655707,-0.0595177,-0.117763475,0.07624083,0.023475822,-0.06898834,-0.013825594,-0.02751594,0.036234483,-0.033624254,0.18047832,-0.046104487 +5.3.3.14,"While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs [3]. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis.",384,1.0,-0.089228064,-0.06250275,-0.102304466,0.006005265,0.067608885,0.05681048,-0.12898852,0.09197522,0.015649265,-0.053118907,0.06494857,-0.095958486,-0.0830891,0.038169853,0.013870321,-0.0118028205,0.03360708,-0.010977407,0.03393982,-0.058714688,0.022179862,0.05111059,-0.074949525,-0.006034323,0.029293664,-0.007341914,-0.00451844,-0.005035105,-0.0366945,-0.039065607,-0.01957621,-0.06983816,0.027528051,-0.0602654,0.12041812,0.031500496,-0.02045624,-0.08480222,0.1411796,-0.007108903,0.03255505,-0.025029069,-0.031504314,-0.0087710265,0.041916482,-0.042548534,-0.019115524,0.1052891,0.019707045,-0.065939695,-0.011196977,0.009052281,-0.0632649,0.0058467975,-0.04246741,-0.0038312527,-0.0011484631,-0.050359145,-0.039468717,0.021185698,0.04394661,-0.0574014,0.038786314,-0.0149849495,-0.016068453,-0.056812968,0.043267578,-0.12196879,0.016207622,0.059097372,-0.110521846,-0.039011482,-0.005117055,0.09604286,-0.016881384,0.08258249,0.0047493544,-0.069018796,0.022911534,0.010333933,0.038776234,0.051109925,-0.0112239355,0.06425555,0.084498,-0.023318976,-0.006992908,0.0037970378,-0.011971298,0.08100009,-0.01000652,-0.017111294,0.014345629,-0.019006852,-0.07555401,-0.0025783824,-0.030084733,-0.024626182,-0.059454482,-0.03533957,-0.03173012,0.025602717,0.013581595,-0.090826534,-0.064776294,-0.013284452,0.006702576,0.061817426,0.007813865,0.0044316035,-0.05848202,0.0024099564,-0.014303797,-0.012629581,0.026480455,0.07534828,0.0033029926,-0.12713344,-0.028176,0.012506662,-0.0537474,-0.095924206,0.058579307,0.029960072,-0.038956918,-0.057060335,-0.013527078,2.9442155e-33,-0.0023764374,0.03793904,0.021151595,-0.0043791225,0.05863162,-0.014409164,-0.10241912,0.018134313,-0.023878574,-0.08003142,-0.014967949,-0.097533405,0.051088937,0.027402712,0.017824566,-0.008340706,-0.05887442,0.09309662,0.06975439,-0.054505862,-0.011789679,0.051180657,0.02288229,0.0099000605,0.0291341,0.07913137,-0.061804958,0.052321296,0.057819992,-0.006916062,0.05290666,0.038693674,-0.09833286,0.020531077,0.087227836,0.0068229027,0.039914817,-0.049622543,0.052866116,0.05105709,0.10775004,0.099399306,0.03937068,-0.019403325,0.026323492,-0.01684161,-0.050830357,0.03160202,0.012059046,-0.040459152,0.058423087,0.0442845,0.030062651,-0.05566118,0.006145369,-0.022533622,-0.023534281,0.04366523,0.031050952,-0.01729579,0.007589496,0.03318103,-0.039904706,0.010051791,-0.07240217,0.054188427,-0.083423935,-0.016932627,0.03145137,0.05485823,0.03083873,0.012080214,0.048675176,0.045897353,0.027709482,-0.043613788,-0.07998963,0.088711776,0.01965383,0.038379993,-0.00013227854,0.025462143,-0.031218989,-0.03972324,-0.024444632,-0.04603983,-0.021881914,0.038584854,0.09692433,0.017506422,0.053632252,-0.043724895,0.009868412,0.047202297,-0.0002022517,-4.3967827e-33,0.07077615,-0.10705682,0.049499657,-0.10300986,-0.07606687,0.0506133,-0.0091951145,-0.036966633,0.062472127,0.0008223657,0.106187746,0.0055067353,0.072805345,-0.037942618,-0.000552592,0.014330471,-0.07300857,0.0054887924,-0.026222536,-0.044665262,0.068116255,-0.02152105,0.033251308,0.048610494,0.039309867,0.08529317,-0.05791479,-0.004023703,0.036742676,0.011355131,-0.03135964,-0.0055915574,-0.07413775,0.0019358615,-0.08618824,0.012121873,-0.06870578,0.0713763,-0.031333476,0.014801065,-0.0009002895,0.019422876,0.0021710624,0.008901825,-0.016757429,-0.0021715846,0.016169913,-0.10232019,0.011607664,-0.05270104,0.06268204,-0.022864023,-0.027969988,-0.001134628,-0.012607301,0.101800345,-0.003827901,0.010877783,-0.019802995,-0.07634419,-0.05620847,0.012481803,-0.01886591,-0.053672384,0.08358215,0.029399553,-0.04821406,-0.024842765,0.03712827,-0.06618903,-0.006180792,0.026822772,0.018524198,0.002114436,-0.014221414,-0.053059336,-0.008223388,-0.03424497,-0.04731534,-0.03172537,-0.09026021,-0.046023734,-0.0560806,0.023250852,-0.08072341,-0.032385234,0.03826968,0.021313962,-0.018125298,0.06933458,-0.039318442,0.024556251,0.037240446,0.089614116,0.08195397,-3.888178e-08,-0.014033743,-0.0004099612,0.04927259,-0.008003662,-0.03734923,0.022772022,-0.031613156,-0.0520599,0.124710046,-0.0673048,-0.03565822,0.07292946,0.082450375,0.030993922,0.005057482,-0.04902796,-0.05492228,-0.016762896,0.055907924,-0.06626372,-0.1119077,-0.019040022,0.012995986,0.02418147,0.020961907,-0.024859332,-0.010136253,-0.012579228,-0.023141418,0.09838416,-0.055134695,-0.004689606,0.025928766,-0.0066446764,0.042343754,-0.017308254,-0.016788617,-0.062461745,-0.08088901,0.09459839,0.09566432,0.064383484,-0.106102005,0.034116562,0.04264334,0.012214903,-0.004182294,0.012344154,-0.05882981,-0.01677771,0.03276285,0.0025954712,-0.038731482,-0.008178463,-0.039571404,0.033403367,-0.021138502,-0.077972814,-0.035701197,0.07112391,-0.006837352,-0.012511886,0.1838276,0.0011742546 +5.4.99.18,"In eubacteria, fungi and plants, this enzyme, along with EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase, is required to carry out the single reaction catalysed by EC 4.1.1.21, phosphoribosylaminoimidazole carboxylase, in vertebrates [6]. In the absence of EC 6.3.2.6, phosphoribosylaminoimidazolesuccinocarboxamide synthase, the reaction is reversible [3]. The substrate is readily converted into 5-amino-1-(5-phospho-D-ribosyl)imidazole by non-enzymic decarboxylation [3].",384,0.99999994,0.011048709,-0.017728396,-0.10004118,-0.04385977,0.035559166,0.04683509,-0.0647851,-0.009946612,0.044755142,0.095740385,0.027887447,-0.042727537,-0.057801057,0.052212413,-0.06718287,0.027120367,-0.05000227,0.047232166,-0.02178313,-0.017561952,0.03629905,0.049657293,-0.001239239,0.03249349,-0.0009097701,-0.055703882,0.040005665,-0.03207511,-0.08097266,-0.08626132,-0.0058783856,-0.06211117,0.08399863,-0.074039124,0.06386754,0.036183875,-0.015797768,-0.12918381,0.06851085,-0.0012370645,0.022353819,0.0076922993,0.05557402,-0.08152446,-0.043799188,-0.0043737944,0.024150293,0.06115225,0.10992903,-0.0771309,-0.00046118864,-0.0050511146,-0.031109283,-0.063062005,-0.09034211,0.050724912,-0.058772303,-0.0068373997,-0.008259407,0.053696334,0.021627182,0.055432715,0.054191973,0.018087033,-0.04185452,0.007267582,-0.022863261,-0.057483118,-0.020220196,-0.007958235,-0.10286738,-0.1137281,0.02080187,-0.0063536325,0.019680286,0.020956742,0.0304489,-0.042717956,0.05010364,0.03755272,-0.06312666,-0.059150033,-0.017411456,-0.08382142,-0.014798263,0.036812294,0.051407676,0.060530875,0.07862823,0.029936183,0.08155538,-0.009002983,0.10071309,0.001557721,-0.007061684,0.031009482,-0.007192287,0.12438557,0.03962097,-0.079153985,0.042420324,0.031466827,-0.0029057406,-0.07779089,0.0024286725,0.027352124,0.039945833,0.09369043,-0.003454653,0.00852386,-0.06415067,-0.033620395,0.012234889,-0.033616588,-0.0027644224,0.06267322,-0.015314306,-0.04348865,-0.041466046,0.02178114,0.041285355,-0.08051218,0.07027315,0.01379862,-0.016451469,0.08658662,-0.08975219,3.3300815e-33,0.019092435,0.07417856,0.07340268,-0.0137967225,0.017404169,0.0034024687,-0.08481263,0.022887561,-0.06600269,-0.07814749,-0.11968656,0.015456896,0.018676998,-0.037425578,-0.0028428205,0.0038911903,-0.08326043,0.029313706,0.023368917,0.07856235,0.022224106,0.026114551,-0.03689456,0.059919108,0.002853017,0.06664155,0.0030664736,-0.029955205,0.054676775,-0.014747346,-0.05387818,-0.052875947,-0.11494233,-0.014481783,0.010550675,-0.047482118,0.003997445,-0.022503264,0.021269336,0.05041602,0.014076403,-0.0010755807,-0.033461217,-0.03313958,0.071777344,-0.018081138,-0.018066876,0.058550544,0.0035927424,0.024062589,0.009262178,-0.025138369,0.13180959,-0.0072113047,0.013933829,-0.0030897525,-0.058667164,0.020634806,0.107730635,0.014010268,-0.027365828,0.070502415,-0.022467263,0.018155182,-0.020847818,0.0092194965,-0.042082865,-0.0637156,-0.011769396,0.04151593,-0.022581596,-0.086011745,0.0029021096,0.024831144,0.05912847,-0.06831734,-0.07648207,-0.037935905,-0.010206924,0.029395478,0.024090763,0.07698328,-0.0121875405,-0.026329082,0.09303171,0.027259745,-0.046476908,0.011466151,0.004140787,0.083004214,0.048252158,-0.126308,-0.02990907,0.053564295,0.0066973944,-3.701518e-33,0.1591778,-0.0840004,-0.0048817056,-0.014140615,-0.027375225,0.009081283,0.020835927,-0.0064711943,0.093561366,-0.065387644,0.01270723,-0.029425474,0.104262576,-0.023023017,-0.02613191,-0.037615642,0.044696625,0.04927262,0.0023344306,-0.003975323,0.012243967,0.0183899,-0.0014525193,-0.011636055,0.035538994,-0.011693695,-0.017950447,0.05157817,0.013392498,0.0040278104,-0.052733924,0.023351502,0.002188147,-0.01963154,-0.066731915,0.044178713,-0.07192365,-0.03454062,0.06982274,0.041372944,-0.05182789,0.04570561,-0.03195233,0.0025829591,-0.0089039365,0.055898797,-0.09093833,0.04328352,0.0041367873,-0.021235261,-0.0018445664,0.02012259,-0.011588827,-0.01009447,-0.00697922,0.02178729,0.028865144,0.092128985,-0.010301795,0.049777344,-0.05339586,-0.049828928,0.09209484,-0.06453209,0.05899891,0.07309487,-0.017199626,0.080928214,0.06241629,-0.04937266,0.059522122,0.026297344,-0.021887721,0.046486795,0.057524946,0.0046502305,-0.07033803,-0.037598144,0.021102328,-0.050763164,-0.01635668,-0.045572605,0.07186382,-0.03408561,-0.020068187,-0.074360475,0.078900985,0.034618974,-0.028799199,0.0674342,0.042560462,-0.046885878,0.043138247,0.075027145,0.028492127,-4.2335582e-08,0.047076035,-0.024824217,0.050137684,-0.13219126,0.014290685,0.043524045,-0.005316654,-0.00083085016,0.08808592,-0.077534325,0.035307128,-0.016447034,0.010236078,0.075671196,0.049237754,0.04133958,-0.105532594,-0.0029335963,0.008787146,0.0739586,-0.009928893,0.013404492,-0.14661314,0.036657117,0.015658202,-0.040845204,0.06011722,-0.006052932,-0.02437902,-0.0044553992,-0.0672787,-0.008188873,0.008243394,-0.0049135955,-0.05707085,-0.02955489,-0.06774624,-0.019522663,-0.0858079,-0.027881352,0.045984797,-0.06175114,-0.06902663,-0.038882796,-0.036681492,0.0037103621,-0.003621323,0.0565635,-0.050021764,-0.03456027,0.035093065,0.0037133144,-0.0036828197,-0.09924702,-0.03370036,-0.008738183,0.037638534,-0.07910228,0.010401183,0.0013426129,-0.026177306,0.016358657,0.15670188,-0.015223184 +6.3.4.18," In Escherichia coli, this enzyme, along with EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase, is required to carry out the single reaction catalysed by EC 4.1.1.21, phosphoribosylaminoimidazole carboxylase, in vertebrates. Belongs to the ATP grasp protein superfamily [3]. Carboxyphosphate is the putative acyl phosphate intermediate. Involved in the late stages of purine biosynthesis.",384,1.0,-0.015444194,-0.017612226,-0.046732716,-0.047840573,-0.041507076,0.053485997,-0.028054018,0.012877867,0.048260007,0.0064392155,0.08261856,-0.048977014,-0.057934914,0.07068574,-0.071853414,-0.008503787,-0.027994536,0.020266306,0.044269357,-0.06799432,0.06562617,0.0631936,-0.0103667425,-0.013230359,-0.017241586,-0.0411746,0.023976136,0.0041910606,-0.045760524,-0.048987687,-0.07283533,-0.079416275,0.0514874,-0.04268057,0.081627235,0.08313696,-0.07227314,-0.12132326,0.08250285,-0.0008241292,0.04322994,0.0014001617,0.04252098,0.029092824,-0.05989616,-0.005523478,0.07650344,0.06716001,0.10928578,-0.06959563,-0.03425901,-0.0033221715,0.04711853,-0.07972804,-0.04515927,0.016129721,-0.06927444,-0.01633713,-0.025555952,0.010445338,0.022433965,0.015208546,0.021883573,0.027651215,0.020711472,-0.051679097,0.034189478,-0.025426935,-0.020172335,0.01574518,-0.0843314,-0.09242533,0.046957385,-0.022179078,0.00372067,0.0052331155,-0.035718385,-0.069595695,0.016613513,0.028833553,-0.009012985,-0.06758219,-0.0039189877,-0.058221336,0.01691313,-0.0011997556,0.04961815,0.046770994,0.006724414,0.0109424405,0.034150902,-0.052344576,0.07849007,0.0006354193,-0.030378606,0.025908738,-0.028364776,0.045861326,-0.037891507,-0.0723931,0.040998608,0.09909924,-8.185138e-06,-0.054385766,0.034120668,0.033393834,-0.008257193,0.09753931,-0.041756462,0.035077132,-0.084684774,-0.006177012,-0.032033425,-0.0033909047,-0.012531019,0.07939011,-0.07178396,-0.04263542,-0.039198317,0.02276191,0.0012693186,-0.1283556,-0.048430625,0.056916162,-0.042876262,0.040107593,-0.12857993,3.527901e-33,0.05586706,0.02563935,0.052623317,-0.044319738,0.021408288,-0.008450396,-0.076001756,-0.021550871,-0.10071359,-0.041488495,-0.04793677,-0.04906905,0.05838166,-0.040871285,-0.043035984,-0.046400547,-0.13884364,0.055985987,0.07352292,0.07053163,-0.0072901426,0.059885327,-0.017604444,0.04850078,-0.0044450504,0.06041273,-0.07084722,-0.0103119565,0.055975653,0.025986966,-0.005775928,-0.067103006,-0.12683515,-0.020598402,-0.0028081264,-0.12888089,-0.009323699,-0.06993997,0.009357378,-0.0021727912,-0.03097864,-0.01171141,-0.012930499,-0.015183179,0.056191232,-0.07288147,-0.030370465,0.09078593,-0.0021582094,0.09841349,0.010880491,-0.05244868,0.14317764,-0.030692045,-0.0253417,-0.0017236936,-0.09513244,0.01715685,0.039172616,0.03445101,0.02049339,0.05960351,-0.04643818,-0.0052649546,0.0047576395,0.047874793,-0.08342804,-0.11191872,0.030746419,0.1408614,0.011064215,-0.0795654,-0.0028873133,0.016383192,0.044104386,-0.006382405,-0.02739294,-0.012079776,-0.045857444,0.039821956,0.025039548,0.034326516,0.05810483,-0.02788357,0.030279594,0.01542358,-0.013204867,0.014268776,0.051752217,0.062211484,0.037704617,-0.066224575,-0.05885807,0.0582572,-0.0029024028,-3.6803457e-33,0.15517697,-0.06000482,0.05548034,-0.0580378,-0.038969312,0.0064019086,0.031658817,-0.01693269,0.076219074,-0.0097181685,-0.014985586,0.010000908,0.038036417,-0.053286895,0.016406002,0.010866546,0.0030112455,0.015070678,-0.003221915,0.0057527884,0.0158322,0.061577298,0.074413896,0.06537849,-0.018454911,-0.01575271,-0.009298934,0.028639872,-0.018307747,-0.015866134,-0.052420996,0.011851816,-0.027011845,-0.014713158,-0.09108982,0.0046103895,-0.080009975,0.042930305,0.059505362,0.082242735,-0.0008354288,0.07127894,-0.037450995,0.037695955,-0.008670152,0.04755736,-0.030013476,0.07159049,-0.0021528234,-0.0781026,-0.015385783,0.04548777,0.07903465,-0.038276635,0.046501476,0.06477724,-0.0070397905,0.042042725,0.0029152303,0.026206085,0.008023866,-0.03391991,0.04885538,-0.019989356,0.088195205,-0.0034077584,-0.04324017,0.025516635,0.0088442685,0.026117373,0.023554275,0.050249334,-0.010583064,0.056453966,0.04150526,0.030175462,-0.09827855,-0.07308667,0.030065497,-0.00083940034,-0.03923823,0.03687989,-0.0015310372,-0.021272263,0.014142512,-0.037872758,0.047677256,0.07155698,0.025584007,0.03274246,0.035606995,-0.024141142,0.041790802,0.06540912,-0.022486085,-4.062339e-08,0.09309255,-0.004441678,0.07034899,-0.105583504,-6.75561e-05,0.07156105,0.0075564585,0.010437262,0.0964895,-0.039390992,0.030818118,0.0075145364,0.061939504,0.06211983,0.03922341,0.056200046,-0.07092521,-0.00771942,-0.013134269,0.031833556,-0.009059685,-0.009884597,-0.09465073,0.11059006,0.0368647,0.0010631584,0.062058028,0.04075566,-0.07130293,0.0022687481,-0.024121244,-0.042229597,0.00047942498,-0.02737201,-0.05720532,0.01319132,-0.062385686,0.006915302,-0.11156203,-0.001850657,0.016002435,-0.07284584,-0.010650968,0.007525437,-0.008632418,0.06670502,-0.006068783,0.041327823,-0.002765186,-0.05607079,-0.0036466846,0.019170716,-0.08527483,-0.043944098,-0.025656613,-0.03832033,-0.018015124,-0.08476951,0.019420454,-0.027979251,0.012542196,0.07319134,0.1433178,-0.04010303 +4.2.3.23,"Requires Mg2+ for activity. While germacrene A is an enzyme-bound intermediate in the biosynthesis of a number of phytoalexins, e.g. EC 4.2.3.9 (aristolochene synthase) from some species and EC 4.2.3.21 (vetispiradiene synthase), it is the sole sesquiterpenoid product formed in chicory [1].",384,0.99999994,0.0011162685,-0.044812102,-0.06496757,0.052927904,0.03450172,0.01598207,0.0007555081,0.050300647,0.07894008,-0.048802003,0.022623451,-0.007923592,0.029056016,0.0035599282,-0.040152952,-0.05162338,-0.010811277,0.014404444,-0.002465695,-0.01439426,0.07419719,0.03638257,-0.0009788967,0.047361504,0.06934206,-0.07600329,0.013108488,-0.04454481,0.043295793,-0.005908503,-0.041461095,-0.055963706,0.059237234,-0.026740968,-0.059222065,0.060798433,-0.03132833,-0.041325405,0.026908947,0.0336963,0.05605214,0.009476709,0.003525512,-0.011650539,-0.07289863,-0.06430104,-0.0027107866,-0.09711282,-0.006143011,0.010743772,-0.095376156,-0.07583763,-0.092745334,-0.010371917,0.013714458,-0.020294145,-0.06155119,-0.011212493,-0.0022810185,0.07181704,0.009712908,0.049121432,0.005425818,-0.04864267,0.019777687,-0.0007645808,0.0145374015,-0.08744893,0.025373118,-0.07543544,-0.046074703,-0.09120213,-0.02067874,0.03883851,-0.05504887,0.03317561,-0.025426783,0.09721897,0.036774915,-0.01963999,0.026444094,0.048245553,0.034392715,0.108193874,0.056046493,0.0076387967,0.0007427633,0.07429702,0.037210606,0.03925253,0.104582466,0.032800052,0.029125668,0.006920173,0.005612411,0.048988204,-0.00031868974,-0.03546177,-0.01837438,-0.031897765,0.0026525785,0.045648817,-0.093887895,-0.008219448,-0.006755472,0.029103182,-0.041253828,0.0051255208,0.019900033,0.00250668,0.06187223,-0.009205327,0.040695764,-0.007958131,-0.01861985,0.08428695,-0.015098243,-0.06694454,0.00038485418,0.060218588,0.024781967,0.016652273,0.041300073,0.030047087,0.024979439,-0.0022165324,-0.03351851,3.7268666e-33,0.034402147,0.026059419,0.02400069,0.09540198,-0.036789823,0.06485893,-0.069126435,0.089429855,-0.014681251,-0.07166911,-0.14617755,-0.07907725,-0.047399063,0.09418751,0.010934443,0.031533744,0.010579794,-0.05421247,0.084923014,-0.022032661,-0.037202608,-0.029987961,0.007321901,0.00017834606,0.019778864,0.061303183,-0.053123247,-0.06766921,0.038524643,-0.008624932,0.023796897,-0.083599284,-0.038226046,0.033308234,-0.031766552,-0.03160611,-0.015207942,-0.046336774,-0.05605681,0.03554696,-0.046076376,0.0990372,0.006195387,-0.010954845,0.100524954,-0.029592618,-0.05570387,0.11849385,0.07576567,0.06381468,0.030209033,0.010018799,0.049090926,0.028501952,-0.08755877,0.01274168,-0.00459274,0.0071472777,0.039490692,0.052147005,0.026783334,0.040976323,0.020022098,-0.022012768,0.053288102,0.12266148,-0.12126219,-0.06939128,-0.030851338,0.091612965,-0.007432242,-0.09859024,0.041476496,0.036164474,-0.027478615,-0.03171728,-0.08861257,-0.04276558,0.026998544,0.014347582,-0.039831635,0.013823909,-0.0028799113,-0.008314772,-0.04833061,-0.03480184,-0.02804433,-0.024183286,0.029276783,0.060174104,-0.024770698,0.02315676,-0.058273323,-0.00911089,0.008060399,-2.9483457e-33,0.042765986,-0.07397796,-0.004610464,-0.0030011998,-0.048141796,0.04931655,-0.051125523,-0.098223396,0.036602255,0.043509766,0.040978793,-0.004352931,0.066156015,-0.039934907,-0.039424513,-0.016115708,-0.046680134,0.06384178,0.03904281,-0.038164075,-0.04268254,0.056721296,-0.014674252,0.0061780256,0.07842118,0.011531099,-0.0024633426,0.044349045,0.008416856,0.037977237,-0.0004761112,0.014603242,-0.04433252,-0.012997373,-0.03719168,0.055681914,0.008384781,-0.023395568,-0.01602884,0.055492435,-0.0072514876,0.012587179,0.06923188,0.0821814,0.072181754,0.034132276,-0.050077848,0.026668733,0.073524036,-0.047840673,0.025482893,-0.024473138,-0.039410792,0.02879094,-0.028733911,-0.006518029,0.008102808,0.011549561,0.0021405106,-0.10911487,-0.007988605,0.04942987,0.01603096,-0.07886144,-0.00036043886,0.03616985,-0.016039252,0.13229114,0.0637512,-0.002583105,0.07428478,-0.01752686,0.08209845,-0.028802939,-0.08843626,0.0628572,0.037444733,-0.044838067,0.056681562,-0.066163205,0.023840198,0.046021048,0.0231174,-0.061208535,-0.084569156,-0.016055861,0.050271682,0.12448852,0.03707921,0.03261408,-0.028048301,-0.029771946,-0.045481514,0.042469792,0.10669776,-4.9365884e-08,-0.006846844,0.021592677,-0.05021624,-0.016989116,0.012062728,0.026809596,-0.051983733,0.02054475,0.027997691,0.04082878,-0.02402104,-0.023809081,-0.03516179,0.012058305,0.048896223,0.022580082,0.002596822,0.04802617,-0.04709444,0.008769667,-0.061714597,-0.027209146,-0.13769737,0.007938842,-0.018673088,-0.20236678,-0.03348568,0.031604566,-0.0119974585,0.0040675956,-0.0018904296,0.0039386186,0.020261273,-0.010141217,-0.07509766,0.020060934,-0.029449401,-0.053544287,0.016269794,-0.06108232,-0.0125192,-0.101921506,-0.050373584,-0.04510482,-0.061568722,-0.00669044,0.051993966,-0.052231465,-0.03347838,0.07162937,0.062591165,-0.031978514,0.05414145,-0.017377574,-0.048163123,-0.026153086,0.001457008,-0.06268058,-0.014849134,-0.14043258,-0.039712727,0.03203246,0.22954115,0.0052511096 +1.5.1.35,"1-Pyrroline forms spontaneously from 4-aminobutanal, produced by EC 2.6.1.82, putrescine aminotransferase. This enzyme forms part of the arginine-catabolism pathway [3].",384,1.0,0.001885582,-0.08550945,-0.07475603,-0.07327515,0.014557969,0.11589881,-0.010296263,0.037161328,0.08951794,0.040713377,0.023925005,-0.0037725815,0.007441551,-0.0064886794,-0.026001547,0.03244663,-0.16480036,-0.061315704,0.008799109,-0.077083394,0.020336108,0.043463554,-0.0014137587,0.0010334576,0.008980919,-0.023506207,0.060360894,0.01009293,0.017667828,-0.03088717,0.021880245,-0.06904909,-0.08058622,-0.064542875,0.076814756,0.056787927,-0.0771596,0.03272396,0.015218589,0.00070644316,0.051222544,-0.056436803,-0.042839877,-0.013082867,-0.042251255,0.011858633,0.13720733,0.0022014058,0.039553627,-0.006998888,-0.006620702,-0.010392792,-0.023182089,-0.057212427,0.024824878,-0.0071961833,-0.054194584,-0.0011682544,-0.02607561,-0.0080007315,-0.00025599575,0.0010784593,-0.01792482,-0.07701136,0.019418314,0.045371085,0.056716427,-0.05569677,0.08447525,-0.02351756,-0.06731868,-0.037674878,-0.0031958423,0.05380945,-0.04493642,-0.024291446,-0.03127334,0.026757052,0.036901794,-0.036747225,0.015088286,-0.02024065,-0.05044505,0.048394248,-0.010890678,0.022072114,0.022882666,0.032116875,0.032024488,0.018777028,0.019019421,-0.022796491,0.0086647635,0.0031037838,-0.012161435,0.029156344,-0.011318295,0.066598274,0.0857523,-0.060952608,0.033323694,0.064616434,-0.10284473,-0.009187098,-0.008846971,-0.008226475,0.023019923,0.058540974,-0.01937422,0.024292057,-0.028264023,-0.0023128227,-0.003623462,0.03061213,-0.026207676,0.11687291,0.064612575,-0.030012678,-0.093837604,0.005161558,-0.009910189,0.082922675,0.122103445,0.15724343,-0.055229206,-0.020757565,-0.03748984,1.813587e-33,0.039873898,0.035370335,0.09372877,0.069786735,-6.973107e-05,0.01458785,-0.11079665,0.027915474,0.024622312,-0.057808034,-0.08906166,-0.14260073,0.0299952,0.011468561,-0.056065958,-0.053389277,-0.032240722,-0.0029034605,0.024853349,-0.042462397,-0.033801716,0.12363664,0.013264696,0.026804512,-0.024231795,0.031725008,0.0047511873,0.03160849,0.023757923,-0.0131124165,-0.00542844,-0.11570939,-0.12505788,-0.06317212,-0.0015373427,-0.082542256,-0.004629043,0.028509082,0.05657863,0.0996166,0.012250088,-0.046435595,0.00018919728,-0.030951703,0.0939855,-0.050442975,-0.050503585,0.13191798,0.0062494213,0.033227,0.011490771,-0.032644335,0.13653886,-0.006907849,-0.090401314,-0.044840265,-0.055511516,-0.03654394,0.028072085,0.0818025,0.07983678,0.0711829,0.0047928253,0.03670722,-0.020732211,-0.01791017,-0.004357671,-0.06639645,0.005317007,0.063251875,-0.034161266,0.019406999,0.043614883,-0.029904798,0.09297247,-0.062277015,-0.13228846,0.052020885,-0.008920458,0.011898329,-0.04144425,0.01465724,-0.0013473621,0.0013237187,-0.006887486,-0.025072927,0.031612214,-0.077302285,0.006116468,0.08596641,0.0020122656,-0.064959094,-0.085338086,0.009924802,0.051623743,-1.847383e-33,0.031083599,-0.03605448,-0.008958211,-0.04430391,-0.061143145,-0.0014689566,0.047667872,0.044301454,0.010657652,0.018533595,0.056857638,0.007787426,0.008620962,-0.06099266,0.03075102,-0.05473499,-0.04641687,0.042873222,0.0824791,-0.0007278425,-0.04223517,-0.050389376,-0.078968294,0.03889749,0.029066501,0.072196506,0.030925836,0.07076535,0.041450035,0.03242448,-0.012976701,0.011144931,-0.019057613,0.004749165,-0.08702437,0.0065644947,-0.021105466,0.02865094,-0.02424375,-0.03363549,-0.0021480767,0.066612706,-0.0058958055,0.008364481,0.020834649,0.0144501785,-0.03555308,0.018995382,-0.049315363,-0.07674506,0.057935867,-0.016737893,0.025651108,0.0030677856,0.04645846,-0.009386598,-0.03667559,0.021336185,0.05489677,0.011694486,-0.011475884,-0.058422662,-0.0044585564,-0.013121908,0.070165426,-0.03405635,0.0035748163,0.08409235,0.0059268624,0.039042372,0.09955817,-0.027623227,0.009632476,0.052306034,0.026270129,0.056272954,0.017547699,-0.03088538,0.03809409,-0.0787197,-0.04834664,-0.04096143,0.0077617853,-0.061808214,-0.042724237,-0.06170822,0.077448696,0.1059039,0.043906815,0.043128207,-0.015280594,0.012597177,-0.022890652,0.089721195,0.04021793,-3.3115782e-08,0.07451843,-0.0143817095,0.032995164,0.054048467,0.0040916135,0.032090753,0.039387498,0.025433296,0.023984523,-0.06870242,-0.051643744,-0.03254552,0.040490467,-0.010227781,-0.0046883873,0.06641092,-0.0307106,0.04606644,-0.0076839565,-0.055754837,-0.09000259,0.037879843,-0.14495982,-0.064303905,0.012750082,-0.025563333,-0.004275611,0.08923252,-0.050701104,-0.049361628,0.046734117,-0.04575552,0.018754175,-0.07344731,-0.05321743,0.034424085,-0.027484877,-0.023027869,0.048187103,-0.029700559,-0.06744651,-0.014338492,0.024171762,-0.041029118,0.028217966,0.023753263,-0.059945226,0.004829132,0.010426515,0.00795849,0.027080012,0.051285036,0.0412837,-0.093457736,-0.09388586,0.03194665,-0.07343179,-0.08479964,0.05905976,-0.07645282,-0.0048714564,0.031518288,0.07057465,0.037896026 +1.8.4.11,"The reaction occurs in the reverse direction to that shown above. The enzyme exhibits high specificity for the reduction of the S-form of L-methionine S-oxide, acting faster on the residue in a peptide than on the free amino acid [9]. On the free amino acid, it can also reduce D-methionine (S)-S-oxide but more slowly [9]. The enzyme plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged. In some species, e.g. Neisseria meningitidis, both this enzyme and EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, are found within the same protein whereas, in other species, they are separate proteins [1,4]. The reaction proceeds via a sulfenic-acid intermediate [5,10].",384,1.0,-0.026922317,-0.06996577,-0.034720507,0.050743975,0.13812672,0.0716185,-0.11155744,0.110350825,0.060065426,0.015520191,-0.014026686,0.031830695,0.016598502,0.034312293,-0.048310533,0.011106318,-0.0009955,-0.0017473212,-0.0011063621,0.0051210793,0.028012617,0.0023871353,-0.103295125,-0.037252285,0.05258468,-0.060833875,-0.0060507394,0.013237661,-0.051950347,-0.019815313,0.044451505,-0.06633027,0.062416025,-0.019468797,-0.012434387,0.059216868,-0.025079057,0.021709528,0.005355433,0.0003910955,-0.032970443,0.034185246,0.0119379675,-0.05182621,0.04996198,0.021374779,-0.05860573,0.037609145,0.048114277,-0.061466943,-0.042396113,-0.021365494,-0.079769075,0.031387787,-0.0062625613,0.020980094,-0.040657766,-0.02172466,-0.050365027,-0.048916895,0.005981185,-0.058252696,0.06083366,-0.02378779,0.086416565,-0.06464919,-0.0050311885,-0.055345807,0.060429435,0.0004945535,0.059972808,-0.035469804,0.008332097,-0.013020839,-0.013341105,-0.0057148505,-0.056869477,-0.017077373,0.07443915,-0.04816686,0.081656896,-0.004363951,-0.016099427,0.08633714,0.03902258,0.009510402,-0.022208035,-0.06641067,0.06994743,-0.008973168,0.001776418,-0.04166001,-0.032110352,-0.06019191,-0.08335688,-0.04044961,-0.0156198675,0.10213479,-0.10510878,0.0033026775,0.026491288,0.035651874,-0.13890149,-0.09011598,-0.07388523,0.0208801,0.0680722,0.05379475,-0.0021289259,0.014562624,0.053037472,0.01902791,0.018931702,-0.0072935526,-0.06359842,0.055184145,0.07451767,-0.057064503,-0.12757984,0.011996558,0.015118519,-0.031630475,0.044929933,-0.026281066,0.03308058,0.032205496,-0.043750864,1.731985e-33,0.0471593,0.030232139,-0.0030856188,-0.0074529047,0.049574565,-0.022654936,-0.111574546,0.010558629,0.0162639,-0.031534728,-0.06747435,-0.037565615,0.015021799,-0.04257667,-0.06815553,0.014129685,0.023346448,-0.027591424,0.02365889,-0.02652679,-0.018719222,-0.0023113408,-0.0055201375,0.052250035,0.03987562,-0.013912553,-0.015175667,-0.026953982,-0.0178043,-0.0069020353,-0.08476811,0.015855994,-0.07845296,0.08207514,0.038054105,0.048985258,-0.07687797,-0.050622568,0.04662636,0.0206239,0.009226911,0.085599996,-0.03231244,-0.026748061,0.07214166,-0.029103063,-0.07108687,0.11950314,0.04633323,0.046568837,0.035062235,-0.051116824,0.10533187,-0.011096939,-0.10225961,-0.023468291,-0.0054970025,-0.052551437,0.060712334,0.11907001,-0.015763298,0.0065138587,-0.028564777,0.0486609,0.025339212,-0.027157351,-0.0068302746,-0.015442373,0.012192413,0.04168213,-0.014474641,3.9982722e-05,0.056047004,0.058870558,-0.029022723,-0.030051205,-0.010114669,0.065707654,0.063119404,-0.030149208,0.048864834,-0.0026428967,-0.03522437,-0.019660467,-0.0024722258,-0.018430682,0.012101691,-0.08260408,0.00060933176,-0.011390258,0.09801227,-0.0752209,-0.0013906538,-0.019986846,0.018225804,-1.26901925e-33,-0.02451672,-0.10757998,-0.01981912,-0.06325645,0.0014780303,0.05883661,-0.0074866544,0.028681519,0.053439915,-0.09113473,0.06555763,-0.059885204,0.0017140328,-0.013852848,0.010058735,-0.0154542625,0.0066107353,0.0925078,0.03678537,-0.06384485,0.023003051,0.0804858,0.0020228089,0.0073107327,0.100271165,0.034684267,-0.031969253,0.058771137,0.072823815,0.08913132,0.030251954,0.02755751,-0.066102,0.017496742,0.032249596,0.09524327,-0.067890026,0.04621363,0.08243942,0.008441975,0.056250773,0.029892681,0.047743987,0.082107216,0.12573817,0.010700875,-0.12516667,0.022710305,0.008574851,-0.11295847,0.080217615,-0.13344482,-0.05311233,-0.01002521,0.036724627,0.061323293,0.015463405,0.015866475,-0.065236464,-0.0056187357,-0.057311267,-0.035188347,-0.06699126,0.021615233,-0.038712893,0.053733006,0.019318756,0.02034428,0.05915081,-0.061076872,0.00966441,0.0045652115,0.05748597,0.017954113,-0.029935306,-0.043713227,-0.076909095,0.08993407,0.051999237,-0.009069474,-0.08281837,-0.0035352814,-0.0072353473,-0.025645938,-0.008538932,-0.039278563,0.0071198633,0.06905039,0.023017475,0.029794784,-0.07506142,0.042781964,-0.013078542,0.0384394,0.05444763,-4.7958707e-08,0.13551545,-0.07456566,0.074664414,0.010543079,0.064279534,0.0020626867,0.007263021,-0.03679847,0.03421937,-0.015307211,0.0101196505,0.10339239,0.005467375,-0.07129278,0.032383706,0.043380853,-0.0047755335,0.044524502,-0.06761591,0.0347218,-0.0071897786,0.016803166,-0.075415015,-0.012604557,0.00039656504,-0.06534845,0.0046455823,-0.020796532,-0.054895174,-0.08755447,0.04142853,-0.030180825,-0.02113934,0.0009967793,-0.04961044,-0.006071095,-0.03543247,-0.024107547,0.097033665,-0.041194208,-0.03731457,0.042529274,-0.020595558,0.055686437,-0.012085418,-0.03539675,-0.03281928,-0.01443847,-0.055457916,0.054918196,-0.0031130183,0.0011913584,0.0163771,-0.054098178,-0.11644319,-0.013273416,0.025427528,-0.00933249,0.01646023,-0.065288514,0.0034384353,0.00336972,0.13217478,0.06730518 +1.8.4.12,"The reaction occurs in the reverse direction to that shown above. The enzyme exhibits high specificity for reduction of the R-form of methionine S-oxide, with higher activity being observed with L-methionine S-oxide than with D-methionine S-oxide [9]. While both free and protein-bound methionine (R)-S-oxide act as substrates, the activity with the peptide-bound form is far greater [10]. The enzyme plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged. In some species, e.g. Neisseria meningitidis, both this enzyme and EC 1.8.4.11, peptide-methionine (S)-S-oxide reductase, are found within the same protein whereas in other species, they are separate proteins [3,5]. The reaction proceeds via a sulfenic-acid intermediate [5,10]. For MsrB2 and MsrB3, thioredoxin is a poor reducing agent but thionein works well [11]. The enzyme from some species contains selenocysteine and Zn2+. ",384,0.99999994,-0.02566868,-0.096393794,-0.07051102,0.05446807,0.15388992,0.069643885,-0.11640888,0.13610305,0.05332618,0.026690166,-0.04605862,0.03409758,0.004470212,0.057942715,-0.008181676,0.0804899,0.036322992,0.030582545,0.0065746163,0.0019260423,0.055219892,0.008938133,-0.09300407,-0.037430543,0.033018097,-0.04798368,-0.0022205515,0.0038952627,-0.068470664,0.011993809,0.027092824,-0.07502871,0.058824718,-0.0006097277,-0.01519631,0.07552989,-0.048628867,-0.00012790758,-0.031242505,-0.040206663,-0.056382142,0.052358203,0.0061465167,-0.058224607,0.06485106,0.009475141,-0.061950266,0.06539564,0.04304848,-0.07078103,-0.04739453,-0.018444246,-0.07329295,0.056378674,-0.011879467,0.014629159,-0.06934021,-0.031442944,-0.061744973,-0.046486463,-0.01706748,-0.031241734,0.07868527,-0.03135607,0.085297704,-0.06299577,-0.025739346,-0.031121407,0.049240373,0.020739641,0.016481696,-0.03572423,0.011140405,-0.018217616,-0.010466758,0.02057873,-0.04045297,-0.00020890051,0.07002343,-0.058644228,0.073527485,0.03221162,0.030372743,0.07602783,0.027707992,-0.0025025716,-0.026031898,-0.041444927,0.06322544,0.023017118,0.059575822,-0.0071519497,-0.030460555,-0.010098312,-0.04638138,-0.076694354,-0.006192584,0.083519585,-0.08322729,0.0005717236,0.0060401764,0.024466425,-0.13785982,-0.09043014,-0.011970848,0.019141624,0.076074496,0.05039424,0.024042698,0.0088813985,0.07945314,0.012842647,0.014370912,-0.025013613,-0.035386063,0.07479137,0.06498244,-0.039678946,-0.114341006,-0.0061851046,0.020782622,-0.019957991,0.04156913,-0.052660007,0.016512016,-0.0020868473,-0.057507046,3.807922e-33,0.06636081,0.017406924,-0.00079388317,0.0103918575,0.036585953,-0.03022352,-0.08298138,0.019496297,0.016099315,0.0068926397,-0.085449964,-0.04625675,0.02129965,-0.052731063,-0.02892745,-0.007456842,0.011375322,-0.019703573,0.05992427,-0.009742345,-0.036729693,-0.015947158,-0.0062663844,0.04319463,0.046821237,0.0042975103,-0.0042421985,-0.03416013,-0.020161476,0.003695769,-0.08088133,-0.019553974,-0.079293065,0.07410734,0.025604106,0.0198158,-0.08125591,-0.047346033,0.009152467,0.0154272,-0.003334728,0.04687457,-0.053012725,-0.05389946,0.07323214,-0.07809041,-0.059633054,0.109800406,0.038525216,0.053284362,0.021236207,-0.046977557,0.12543108,0.012771608,-0.10683717,-0.052793097,-0.0015347246,-0.03449378,0.08155131,0.093219526,-0.06432529,-0.037325356,-0.028232295,0.039275594,0.032918822,0.0019580708,-0.038911264,-0.012903427,-1.7735436e-05,0.052229892,0.007519661,-0.0005976869,0.071342655,0.03199798,-0.03215148,-0.020706788,0.0094163865,0.0671114,0.05145512,-0.0010724475,0.038095716,0.007846282,-0.05125372,-0.038280472,-0.034841858,0.006555852,0.0018492062,-0.09713657,0.027308252,-0.012815663,0.090992585,-0.06736847,-0.011206203,0.0022750297,0.0009991537,-2.3421651e-33,-0.0007273779,-0.09622357,-0.0059273466,-0.057445724,-0.006435275,0.035715885,-0.019480977,0.0066769742,0.04226476,-0.114161015,0.048569843,-0.064737946,0.003984609,-0.012165545,0.017209275,0.004701037,-0.012280126,0.08767763,0.03524194,-0.059377536,0.022492554,0.07205446,-0.026086517,0.013909212,0.090377375,0.048548702,-0.035110246,0.042294983,0.08571557,0.08893413,0.051489417,0.03351074,-0.06425818,0.0179276,0.023930036,0.09435815,-0.050857086,0.04251182,0.053544957,0.03601245,0.06526286,0.04202857,0.0413824,0.08536181,0.113284,0.025932414,-0.11256918,0.009069101,0.034880035,-0.12228326,0.0888345,-0.1485946,-0.043518018,0.005676378,0.04656691,0.06287706,0.00302537,0.013798548,-0.05773668,-0.037640624,-0.04332403,-0.050162513,-0.049032353,0.0006544912,-0.011488937,0.06954021,0.033639524,0.054274857,0.07333135,-0.06547624,-0.0012761838,-0.015038361,0.072983116,0.007804218,-0.0072394283,-0.035264812,-0.06614514,0.088352434,0.04857565,0.03294261,-0.05687368,0.004121736,0.004731469,-0.030243622,-0.027480591,-0.020583991,0.021051828,0.09124087,-0.004655313,0.024497341,-0.08339783,0.05159821,-0.030277051,0.050125938,0.04747833,-4.966136e-08,0.11011806,-0.08376661,0.073842674,-0.010745881,0.0537534,0.0013091768,0.023663668,-0.0014947667,0.004981962,0.012784314,0.021346962,0.09123258,-0.012583284,-0.086894415,0.049426183,0.024964415,-0.017717026,0.016479118,-0.057437822,0.008742156,-0.015876237,-0.00012796963,-0.049419556,-0.016972303,0.009652416,-0.06900309,-0.014704263,-0.028141774,-0.05494753,-0.04907711,0.010699055,0.006219866,-0.022116456,-0.0030616557,-0.065944575,-0.018794268,-0.015045252,-0.047211252,0.062470358,-0.020531531,-0.049363054,0.0480507,-0.019084135,0.0528846,0.0013461917,-0.03869681,-0.014398015,0.01936989,-0.0882005,-0.006037268,-0.016180953,0.0042100647,-0.0037602035,-0.03668741,-0.12448863,-0.0072004152,0.020045746,0.01169463,0.0087877,-0.07418404,-0.0021272013,-0.0088750655,0.14209996,0.026583984 +1.8.4.13,"Requires NADPH [2]. The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC 1.8.4.14, L-methionine (R)-S-oxide reductase].",384,1.0,-0.056873024,-0.027132249,-0.0073689497,0.018403718,0.074352585,0.009096572,-0.09901396,0.10947663,0.001546109,0.017877113,0.0031659582,0.015029648,-0.020411529,0.049897574,0.01224916,0.03815015,0.032779604,0.047250807,0.02017672,0.030149126,0.0028142903,0.024071481,-0.047515668,-0.017112015,0.07746067,0.01832343,0.014580231,0.04079005,-0.0181477,-0.07372201,-0.012739495,-0.005899328,0.005588896,-0.030024415,-0.026628004,0.10652055,-0.121782154,0.0103149,0.0200866,-0.08636921,-0.015002666,-0.0010957152,-0.039581362,-0.028320063,0.0129001895,-0.011104619,-0.10533262,0.08523871,0.03504867,-0.041539043,-0.08190469,0.02362386,0.022726253,0.058062203,-0.02128438,0.03054986,-0.023690216,-0.009395794,-0.022496797,-0.05716977,0.010455711,-0.022303492,-0.047007304,-0.028147975,0.085618,-0.051192347,0.023421343,-0.0033159563,0.02362472,0.069438286,0.029700765,-0.019049345,0.043940842,-0.027574254,0.049099725,-0.01753934,-0.023566566,-0.022027308,0.055649783,-0.01349917,0.064056724,0.04962548,0.0203123,0.08958822,0.035183884,0.010135975,-0.08256586,-0.05823714,-0.012545249,0.0041986974,0.022679282,0.03898795,-0.046510335,-0.017858585,-0.07628038,-0.012902719,-0.019150313,0.05036905,-0.0286712,0.030016169,0.013260693,0.057296034,-0.17184989,-0.06333164,-0.036752082,-0.0076461597,0.024500722,0.055374287,-0.0199854,-0.037562244,0.08358561,-0.034930795,0.076097436,0.009126387,-0.067811646,0.025007602,0.060695063,-0.006080166,-0.08650561,-0.053159487,0.030243756,-0.025181755,0.011490304,-0.029858086,-0.05711134,-0.0373738,-0.072234906,1.7209384e-33,0.07162412,0.045401834,-0.04618665,-0.057363242,0.06057901,0.006978537,-0.04180197,-0.031532235,-0.026603032,-0.079879284,-0.07866393,-0.055533785,-0.07948628,-0.052525736,-0.0086196065,-0.069787234,-0.0028524108,0.032939278,0.04064089,-0.039738603,-0.007955451,0.01773513,-0.06299258,-0.015191105,0.023882043,0.05011781,0.021360565,0.046188705,-0.05120922,0.025307398,-0.002641766,0.015628701,-0.032505337,0.03590437,0.05132603,0.03798251,-0.08748361,-0.02794651,-0.017785948,-0.012532086,-0.001103782,0.076689094,-0.10126874,-0.0003492844,0.069455065,-0.069249645,-0.027066404,0.059915815,-0.012856401,0.038279008,0.04519864,-0.109702066,0.063323125,-0.073779136,-0.08179208,-0.024799211,-0.033670325,-0.01426565,0.08206145,0.133499,0.0014217929,0.021911629,-0.034300283,0.08917347,0.0002647577,-0.034120545,-0.047173955,-0.039398402,-0.043734163,0.023404913,0.040514488,-0.0012690064,0.02913906,0.05309116,-0.010885438,-0.07123013,0.0060549667,0.007924728,0.016440844,-0.07081477,0.0733754,-0.0093087945,-0.04609438,0.007728586,0.006218921,0.053404134,0.007908199,-0.06396024,0.03908489,0.031192414,0.03915222,-0.114603885,-0.012266609,-0.026174111,-0.00012396708,-1.3870246e-33,0.05242252,-0.055466328,0.08531528,-0.032842036,-0.066830635,0.06397154,0.041054517,-0.07326455,0.06503421,-0.016271332,0.072994374,-0.04404591,-0.042480215,-0.014248595,-0.010836352,0.036464904,0.053413264,-0.012363782,-0.007604136,-0.041854456,-0.02143957,0.051241368,-0.0016951084,0.015328353,0.06476495,0.0056880717,0.0045195343,0.102381155,0.059127122,0.002897024,-0.022138814,-0.0024267929,-0.01567286,-0.031620685,0.0009186497,0.13956375,-0.0487476,0.01956883,-0.012616344,0.032519996,0.0384196,0.02351628,0.054153778,0.08591077,0.063858375,-0.03701926,-0.081992015,-0.05907539,0.037226368,-0.113351375,0.08554521,-0.055588257,-0.01999367,0.059741758,-0.0060548643,0.031906962,0.02417267,-0.0052763885,0.0022400473,-0.0604176,0.027058052,-0.08386187,-0.034332644,-0.009952487,0.11609011,0.02662938,0.010103182,0.10152106,0.07021974,-0.034529496,0.055744767,0.008720584,0.10151659,-0.024878975,-0.017873721,-0.04638822,-0.082694545,0.0922673,0.030400073,0.020540817,0.027956406,0.010659035,-0.0074286745,-0.049089883,0.011050259,-0.06507956,0.05176472,0.10472182,-0.0565752,0.08516281,-0.027005425,0.006584619,0.030937618,0.041449126,0.07341204,-4.0681993e-08,0.08614118,-0.12261948,0.020732377,-0.026266335,0.073271126,0.012196197,0.04596928,-0.028928718,0.00507648,-0.017808462,-0.07641198,0.09519187,0.060822792,-0.06836853,0.07936022,0.027960002,0.007570517,0.06168272,-0.045376398,0.0032222949,-0.04072032,0.001098931,-0.07767433,0.0063672396,0.041533783,-0.0067458893,0.005543846,-0.044555835,-0.016000379,-0.038715012,0.024908833,0.0019258831,-0.013307953,-0.020256223,-0.051501542,-0.011715893,-0.052472673,-0.035228275,-0.012012919,-0.03365488,-0.079784065,0.06305265,-0.004116756,0.08010859,-0.013077883,-0.034790006,0.03182966,-0.016224748,-0.08032319,0.007349242,0.027347317,-0.048503876,0.045905273,-0.10134599,-0.1018514,-0.0007124146,0.04361869,0.030902697,-0.067608535,-0.0935923,0.09425276,0.05269668,0.14804146,0.019415198 +1.8.4.14,"Requires NADPH. Unlike EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC 1.8.4.13, L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate.",384,0.99999994,-0.026446441,-0.064077884,-0.08622848,-0.018345535,0.09469728,0.055592977,-0.115099706,0.14417236,0.020276884,-0.03527151,-0.028783694,0.0038346318,-0.05386642,0.08926242,0.019445121,-0.017852932,0.036169324,-0.009153759,0.048991647,0.028748615,0.039856434,-0.0136349285,-0.0403118,-0.03361476,0.098205894,-0.060227282,-0.0045057456,-0.007934957,-0.03217362,-0.019342411,-0.013189722,-0.052945334,0.031767525,-0.018470561,0.030259127,0.09818908,-0.053392634,-0.018685687,-0.010285843,0.012683734,0.003925919,-0.0076795765,0.02747855,-0.034240283,0.06271651,-0.044943158,-0.06956769,0.08782074,0.0074160374,-0.06499284,-0.065156415,-0.017322727,-0.013962363,0.02106665,-0.032824785,0.041910116,-0.044270784,-0.03804575,-0.04867447,-0.07559916,-0.02243095,-0.0640805,0.07599513,-0.0034528458,0.0357163,-0.05517595,0.011503128,-0.086783245,0.02887674,0.04071564,-0.04114962,-0.045967195,0.0067841373,0.03771226,-0.0060032867,0.006012141,-0.020400824,-0.005817622,0.06018119,-0.02527811,0.010521576,0.0068255183,-0.0600769,0.04452538,0.05778845,0.08403326,-0.023814352,-0.050287735,0.0066638105,-0.035026718,0.029853538,-0.038319577,-0.043391384,-0.034442212,-0.09608615,-0.07793769,0.015268515,0.07427379,-0.088221125,0.013448832,0.014400413,0.09954867,-0.10414742,0.005562494,-0.10395605,-0.010254387,0.040582273,0.078253366,-0.029955007,-0.042290576,0.09641703,-0.0285679,0.044356782,-0.05425047,-0.03000362,0.029778928,-0.01882256,-0.08429839,-0.07008823,0.036254294,-0.017161027,-0.036035225,0.014378379,0.020156657,0.039409645,-0.026685463,-0.05483581,-7.828623e-34,0.08830906,0.025768038,0.013314119,-0.018097002,-0.001015448,0.010381353,-0.100984804,-0.0015924972,0.0098127285,-0.04569322,-0.023344204,-0.0331054,0.03209119,-0.023324851,0.0056670117,0.05856342,0.057593442,-0.041164324,0.05099729,-0.019649202,0.013239522,-0.051614936,0.007005579,0.02527491,-0.004520434,0.0055546435,-0.019471617,-0.0087479185,0.029743258,0.031650223,-0.043830074,-0.004945907,-0.025799604,0.0910515,0.05510736,-0.007951887,-0.078566946,-0.08668882,0.05420385,0.015400851,0.028556341,0.07603641,0.05266546,-0.043267123,0.070206314,-0.044041682,-0.021654759,0.0938939,0.0118645765,0.07369707,0.013491337,-0.020009125,0.07864366,-0.04947178,-0.04332703,-0.032699745,-0.043713048,-0.035129834,0.052491218,0.11747321,-0.04659933,0.026884386,-0.034393903,0.051961552,-0.033213634,0.038189035,-0.07080384,-0.04927611,-0.0039868066,0.075619236,0.040108472,0.015208046,0.052223787,0.07830632,0.03274102,-0.07352056,0.014729849,0.029215727,0.06598945,-0.0028875184,0.038228244,0.00205182,-0.08843022,-0.027469374,-0.020498734,-0.016954431,0.05521748,-0.057519894,0.05692066,0.010560256,0.040816512,-0.079155184,0.027080514,-0.025282675,-0.00032456164,-1.3731644e-34,0.003705956,-0.05757478,0.023713658,-0.0937933,0.02058736,0.05029397,0.03845692,-0.08472992,0.07981078,-0.057413302,0.067905575,-0.0019117502,-0.035211373,-0.04006369,0.062240522,-0.0056571686,-0.043814644,0.016761247,0.05557862,-0.00025363103,-0.0065026027,0.033233058,0.026764093,0.037746746,0.08714268,-0.023431264,-0.04725827,0.111728854,0.054126337,-0.04556056,-0.024926057,0.021450512,-0.03866609,-0.018152641,-0.028001085,0.065097846,-0.06489798,0.008307914,-0.01123863,-0.008054134,0.0735181,0.027065901,-0.020392826,0.029056314,0.07538316,0.015590592,-0.045863565,0.04251062,0.038437095,-0.11127918,0.0757351,-0.111439675,-0.023827696,-0.04684621,-0.0016897279,0.07720145,-0.023514591,0.08141106,-0.018040366,-0.029480038,0.010551505,-0.050983943,-0.048303932,0.018679094,0.044032298,-0.008924636,0.03641757,0.058268994,0.029920189,0.03843502,0.027976654,-0.007838016,0.103999384,0.06604667,-0.01628475,-0.051348176,-0.12040964,0.039785147,0.052319985,-0.072381906,-0.03900821,0.013142948,0.0025769533,-0.015761362,0.09288132,0.010592727,0.04992861,0.021574387,-0.01764306,0.04594515,-0.046914127,0.024121057,0.019487133,0.07321092,0.047747243,-4.1944872e-08,0.17568459,-0.04845463,0.04583098,-0.04166913,0.06831887,-0.0072307307,0.06899424,-0.14542004,0.015113269,0.024937442,-0.035100922,0.08296971,0.030085575,-0.04945565,0.03911962,0.03718266,-0.031673957,0.04400599,-0.06254532,0.027218947,-0.040188223,0.016723376,-0.121779524,-0.007939885,-0.0018859616,-0.045960873,-0.040228695,0.028791096,-0.017249834,-0.05420881,0.07725132,-0.0005986333,0.03887143,0.027688242,-0.059723146,-0.05422555,-0.1010092,0.0013132509,-0.012942038,-0.010254836,-0.021478994,0.021505594,0.016389476,0.054477185,-0.040251963,-0.051491003,-0.016891643,-0.052431025,-0.06054381,0.030094279,0.0033103474,-0.049484078,-0.0172154,-0.11356191,-0.030940318,-0.018198576,0.044785433,-0.051372416,-0.023743697,-0.08914309,0.055255283,0.011333783,0.15201908,0.014601803 +1.14.11.27,"Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys36 (K36me2), which is its natural substrate, to form the monomethylated and unmethylated forms of Lys36. It can also demethylate monomethylated (but not the trimethylated) Lys36. cf. EC 1.14.11.69, [histone H3]-trimethyl-L-lysine36 demethylase.",384,1.0,0.027523972,-0.06915506,-0.13975002,-0.04323647,0.08074229,0.03605057,-0.06427588,-0.015623093,-0.06632863,-0.0100554,0.0024671734,-0.0118134385,-0.026642948,0.01627964,0.066464685,0.041042745,-0.11705461,-0.015069636,-0.10926925,-0.03748811,0.054622218,0.006720652,-0.047272764,-0.054579496,0.020517034,-0.046247263,0.0481036,0.015450411,0.041307874,-0.051202767,-0.0059262817,-0.00720072,0.06174278,-0.081075445,0.058740474,0.024815952,-0.07605411,-0.06584501,0.045959905,-0.0005977971,0.008256374,-0.029213134,-0.015847558,-0.05085198,-0.073806815,-0.0071185674,0.04170694,-0.025539268,0.0025647026,0.02267055,0.0015578197,-0.049238335,-0.0070031364,0.008395344,-0.1385618,-0.075510494,-0.05616529,-0.0012731056,0.06027813,0.010325279,0.017125467,-0.033099286,-0.009907219,-0.014342733,-0.032912977,-0.05362305,0.06431052,-0.03836064,0.04871324,-0.07093774,0.0068212543,-0.058127597,-0.0025982084,0.07399402,0.07607355,0.01033842,0.066710025,-0.03238517,0.041455906,-0.025427124,-0.046090547,0.008320741,0.05664998,0.103802666,0.021456473,0.013884945,-0.07839187,0.05599873,0.05643143,0.02947089,0.029529419,-0.0027565372,-0.09983788,-0.036931343,-0.0016145047,0.07884473,0.06808601,0.01873139,0.027911643,0.0066228267,0.017001625,0.023331648,-0.0835821,0.032862943,-0.005156325,0.031698152,0.010626316,0.070718504,-0.039962865,0.0034266943,0.038065087,0.025290838,0.08012319,-0.009194098,0.03740114,0.06904437,0.016545385,-0.03388184,0.01741481,-0.023206538,0.056547493,0.0419177,0.11885127,0.019108238,-0.009868802,0.018295623,-0.13111572,3.0388404e-33,0.040249035,0.12271989,0.037336785,-0.033962358,-0.030766692,-0.03586302,-0.0841413,0.03549366,-0.02455362,-0.028528856,-0.046162717,-0.03644883,0.08273656,-0.043427017,-0.08508593,-0.00971003,0.056461338,-0.02487296,0.007663573,0.029419381,0.018526437,0.029169124,-0.024537725,0.04536015,-0.001794214,0.028290538,0.06574928,0.014606753,0.04069788,0.023739014,-0.061895967,-0.10300554,0.02310013,-0.0065189386,0.073268145,0.066522926,-0.0907647,0.018926706,-0.028434567,0.03182816,0.11354999,0.05477122,-0.024227265,-0.021096734,0.00473817,-0.018392779,-0.010576959,0.074455656,-0.041568965,0.0554749,-0.020717483,0.02760665,0.078038104,-0.0717309,-0.06271703,0.012357635,-0.024070488,-0.012684338,0.06496133,0.0021468094,0.0051659476,-0.0024348078,0.025905723,0.11773071,0.08639662,-0.03388576,-0.06474397,-0.033928968,-0.06201028,0.010407414,-0.04878586,-0.012886677,0.100513525,-0.03130821,0.04612064,-0.09650457,-0.056984533,0.010985732,0.053915095,-0.004215157,0.058039993,0.013734052,-0.06556355,-0.044376895,-0.07899944,-0.06675126,0.013955645,-0.06511268,-0.021341996,-0.0071748463,0.0026820563,-0.10692301,0.04529322,-0.0067571662,-0.005227708,-4.7290667e-33,0.025594207,-0.021616904,0.04847254,-0.029444223,-0.0046204077,0.00966713,0.13945809,0.00985749,0.025322875,-0.014307255,0.14185254,0.009890978,-0.051864486,-0.032849245,-0.0036177572,0.12050265,-0.00312446,0.08366345,0.03770829,0.0042477157,-0.07064448,0.040677834,-0.05788876,0.08644525,0.04855238,0.015263423,-0.054476522,0.0048198975,0.0700029,0.071935125,-0.024104664,-0.009566399,0.006514741,-0.08706008,0.00010616169,-0.0240105,-0.0332322,-0.041654352,0.042111542,0.023530006,0.032490417,-0.034587074,0.021643989,0.07055482,0.042418137,0.049754854,-0.06467101,0.06758025,0.037083354,-0.04860678,0.0066963267,-0.043889586,-0.062682286,0.06792492,0.030712238,0.029501567,0.059519224,0.09128603,-0.07188439,-0.004038024,-0.05988221,-0.08365998,0.029754024,0.05918311,0.017770587,0.028860986,-0.033421103,-0.0010968024,0.009193926,0.0035791353,-0.0070506814,0.0031665636,0.020302666,-0.06005457,-0.017066821,-0.046769258,-0.045618523,-0.046306167,-0.10378652,-0.040674195,0.03637896,-0.038512707,-0.014265009,-0.01797286,0.013911834,-0.100522056,0.010169289,0.09362098,-0.007431503,-0.028952373,-0.00690283,-0.049470246,-0.04326735,0.068608396,0.09452382,-4.7892637e-08,0.02724219,-0.081439614,-0.020668847,-0.057875205,-0.058827102,0.06996283,0.0076670507,-0.059885576,0.039374866,0.0064036204,-0.0031905863,0.037308957,-0.017557973,-0.054670773,-0.016734777,-0.01179251,-0.080263644,0.1011717,-0.026521567,-0.01412845,0.0065482752,-0.0049404195,-0.033256847,-0.023829486,0.012808279,-0.018901855,-0.028903145,0.008430627,0.047871523,-0.1008816,0.037986793,0.036173068,0.024256267,-0.045362197,-0.10912583,0.0025410322,0.030990738,-0.031000417,0.008225608,0.005578598,0.0270976,0.0027965533,-0.15183572,6.1130326e-05,0.04020083,-0.022927541,-0.028954769,0.07037521,-0.012337848,-0.010462123,-0.063465945,0.035030175,0.026870321,-0.033555042,0.021270731,0.08132104,-0.0573461,-0.0025133267,0.0066004195,-0.055206273,0.025359608,0.006205868,0.111085646,-0.08640232 +2.6.1.82,"A pyridoxal 5'-phosphate protein [3]. The product, 4-aminobutanal, spontaneously cyclizes to form 1-pyrroline, which may be the actual substrate for EC 1.2.1.19, aminobutyraldehyde dehydrogenase. Cadaverine and spermidine can also act as substrates [3]. Forms part of the arginine-catabolism pathway [2]. cf. EC 2.6.1.113, putrescine---pyruvate transaminase.",384,0.99999994,-0.01674902,-0.07077349,-0.09939912,-0.088178016,0.05788945,0.07201026,-0.016123304,0.029044101,0.02816923,0.04550134,0.021553824,-0.0020253225,-0.056526076,0.07467544,-0.004579642,0.014246102,-0.1059732,-0.05409522,0.053248134,-0.06558188,0.071248904,0.061490238,-0.016476564,-0.029794253,0.046201427,-0.0050924625,0.04694022,0.03172417,-0.0059361057,-0.043661278,0.029398825,-0.033107825,-0.03715044,-0.07792894,0.0625236,0.1299287,-0.09250012,-0.010475231,0.04120563,-0.010304266,0.08201448,-0.061617035,-0.086876184,-0.01445533,-0.038758613,0.0104509285,0.11712911,0.04599591,0.03528883,-0.0071568782,-0.0021869252,-0.033660136,0.013279292,-0.042584993,0.02381586,-0.016776444,-0.024309885,0.020265874,-0.0681205,-0.02440951,-0.010977711,-0.0068705454,-0.017692154,-0.04529807,-0.028166348,-0.020263722,0.07270369,-0.060778912,0.04352468,0.0029905676,-0.092059664,-0.09075279,0.032327544,0.048847362,-0.063916795,0.042400345,-0.046048276,-0.026482092,0.00072693644,-0.053929146,-0.01000429,-0.032244463,-0.015770946,0.05294727,0.027880305,-0.0042585437,0.03911723,-0.024247836,-0.009574739,0.0147152925,0.014449287,-0.0036133807,0.04039348,0.01781588,-0.044459544,0.030247664,0.01582052,0.035357065,0.03677285,-0.05233693,0.00989077,0.114987314,-0.03785391,-0.0003566739,-0.05325836,-0.003643368,-0.043738373,0.099259876,-0.009346801,-0.031526253,-0.033598915,0.0007453491,-0.00343946,0.009992515,0.011455622,0.09531125,0.046520315,-0.0472026,-0.03796161,0.025919648,0.001625202,0.042325422,0.09958406,0.13007891,-0.054240465,-0.00041225075,-0.06456657,2.3559486e-33,0.07633085,0.015025524,0.051449515,0.061760385,0.004341278,0.044492047,-0.111798294,0.054282364,0.01870012,-0.041353285,-0.062374294,-0.06630244,0.10233876,0.01741081,-0.07751418,-0.045211326,-0.10350426,0.0076590437,0.08085299,0.0003103324,-0.03442601,0.09138055,-0.012684206,0.035049025,0.0065060616,0.039291583,-0.005704603,0.015774447,-0.0015809705,-0.0063253012,-0.03255937,-0.10518634,-0.12110125,-0.0727916,0.0014541708,-0.050710917,-0.025094414,-0.009175692,-0.0003341543,0.07372917,0.013178435,-0.053534817,0.034612942,-0.04518291,0.02481715,-0.08254414,0.00019237655,0.10643946,-0.04364005,0.039363265,0.047402214,-0.021332292,0.14626765,-0.076254755,-0.10875152,-0.0025644891,-0.053080995,-0.02559812,0.03774449,0.077738054,0.075225584,0.046603914,-0.029574305,0.054795288,-0.027782314,-0.01039797,-0.022795392,-0.08853013,-0.010424366,0.07731026,-0.041556228,0.038637165,0.12343984,-0.019986833,0.03888088,-0.025063993,-0.12620924,0.07686842,-0.016096666,0.0129658505,-0.038308263,-0.028100338,-0.028416542,-0.045700345,-0.010629189,-0.026596723,0.03157375,-0.079548426,0.0059242565,0.042867295,-0.022301912,-0.08672774,-0.056192897,0.0057458933,0.032836057,-2.5441132e-33,0.08180981,-0.096167445,0.009651519,-0.052396804,-0.021863589,0.04912956,0.07535343,0.020413483,-0.029352201,0.009418844,0.06885872,0.029667499,0.024940783,-0.04489828,0.024599746,-0.0073560276,-0.04096247,0.03552954,0.06799581,0.017453972,0.008007129,0.051254228,-0.05317269,0.042521898,0.06288085,0.064257234,0.015079136,0.009293272,0.061043352,0.031090073,-0.035239592,0.038454633,0.004725461,-0.0029718867,-0.05525579,0.043214127,-0.07445495,0.022939272,-0.020273685,-0.029453795,-0.007407456,0.08296655,-0.024770232,0.044774853,0.028649027,0.019795276,-0.03799017,0.034223683,-0.042317595,-0.04377691,0.045963243,-0.0061603347,-0.02275724,-0.012858895,0.03160381,0.018570099,-0.015015241,0.017946372,0.06257325,0.022256155,-0.018790647,-0.05400026,0.010366202,0.0008521335,0.0669524,0.0043272153,-0.010884631,0.08128073,-0.002787283,0.053610157,0.11840771,-0.03408625,0.03225935,0.053583913,-0.010534476,0.016007233,0.0064938054,0.017587198,0.004283115,-0.035275515,0.0008010709,-0.062070265,-0.02864066,-0.049658258,0.0037597152,-0.04431061,0.04093419,0.10970898,0.0038794132,0.017339867,-0.04443005,-0.008354324,-0.057660833,0.09163921,0.08732138,-4.587735e-08,0.091451645,-0.011084519,0.020297885,-0.013491558,0.008923579,-0.012862173,0.06875348,0.00087923167,0.03010621,-0.051542573,0.01822604,-0.0017890906,0.06333665,0.038492493,0.01783071,0.0781371,-0.069231324,0.05113812,-0.016660154,-0.012404226,-0.11407822,0.012401182,-0.14508331,-0.03044151,0.01808252,-0.045484994,0.016506035,0.0430922,0.0055882065,-0.06441431,0.03215189,0.014520989,0.00055036123,-0.045014426,-0.049415,0.020768695,-0.048491437,-0.013378005,-0.014306723,0.0013457524,-0.087301165,-0.104667455,-0.015539827,-0.013855413,0.06066044,0.056131646,-0.03453828,0.014780533,-0.04437793,-0.00027297344,0.010376815,0.018452523,0.021059193,-0.08003918,-0.09939823,0.052059583,-0.06417425,-0.08756592,0.03867109,-0.074538864,-0.009612618,0.03149182,0.14690404,-0.025008697 +2.6.1.83,"A pyridoxal-phosphate enzyme. In vivo, the reaction occurs in the opposite direction to that shown above. This is one of the final steps in the lysine-biosynthesis pathway of plants (ranging from mosses to flowering plants). meso-Diaminoheptanedioate, an isomer of LL-2,6-diaminoheptanedioate, and the structurally related compounds lysine and ornithine are not substrates. 2-Oxoglutarate cannot be replaced by oxaloacetate or pyruvate. It is not yet known if the substrate of the biosynthetic reaction is the cyclic or acyclic form of tetrahydropyridine-2,6-dicarboxylate.",384,1.0,-0.040227294,-0.04909438,-0.04650267,-0.036508787,0.084144376,0.008927861,-0.07192,0.003637507,0.07013722,0.084419556,0.019784087,-0.0050676926,-0.046472337,0.040122725,-0.051346034,0.08089266,-0.1278136,-0.013539271,0.05479723,0.0066225273,0.122861624,0.08034265,0.004604119,-0.018011585,0.0523125,-0.03328542,0.006708908,0.027891414,0.009119354,-0.04514641,-0.050366007,0.0108028315,-0.056690384,-0.090377524,0.044771492,0.12741086,-0.09246455,0.023677142,0.043415368,0.015155313,-0.0068437234,-0.08947341,-0.08237259,0.013306623,-0.046252035,-0.023655435,0.008497192,0.013806597,-0.018618891,0.004781449,-0.031891078,-0.0035278723,-0.062451147,0.00056092173,-0.017975053,-0.039200157,0.01943438,0.09391583,-0.008510427,-0.02986244,0.09530981,0.027830167,-0.005541181,0.014976816,-0.0056244624,-0.047916345,-0.007445863,-0.043919243,0.06395536,-0.11652743,-0.08418192,-0.09494336,0.058143325,-0.002068846,0.019302508,0.016306322,-0.020001387,0.013354492,-0.0051903045,0.03420004,0.057044353,-0.03287022,-0.01894481,0.046137273,0.04854423,-0.0023735643,-0.03961427,0.04315665,0.015547867,-0.037269756,-0.0021904777,-0.008538659,0.004644705,0.016724437,-0.020597966,0.029883886,0.033014454,-0.0011530403,0.054669082,-0.021554139,-0.010111941,0.032181364,-0.114270955,-0.071649,-0.06172468,-0.027801175,-0.05335558,0.026377229,0.018475322,-0.006053064,-0.027667334,0.055078294,0.033743493,0.0740647,-0.008960959,0.11099195,-0.0071966266,-0.0019422111,-0.018829972,0.007813132,0.034073167,-0.01639978,0.020768313,0.06438018,-0.075201534,0.038787328,-0.050009787,4.9134852e-33,0.06938638,0.102360055,0.015612702,0.017785313,0.015227658,-0.018605188,-0.053576473,-0.04414106,0.0021385695,-0.022829799,-0.041519657,-0.08120443,0.03992643,0.0040162955,-0.041470073,-0.0725364,-0.082825474,-0.0035817088,0.097764544,0.010943857,-0.022050163,0.08207875,-0.0676001,0.07129588,0.037687507,0.07104848,-0.0018681284,0.023353662,-0.0038274426,-0.008725472,0.0379626,-0.14592555,-0.043316018,-0.026902882,0.020546004,-0.11548249,-0.054792978,-0.031335834,-0.003722446,-0.013119758,-0.014851287,0.01083824,-0.004778422,-0.023875017,0.08894246,-0.041087367,0.006853329,0.15046398,-0.018562654,0.03558461,0.03729479,-0.0057023126,0.06779028,-0.038095832,-0.07885361,-0.011653451,-0.038830325,-0.028682468,0.079026304,0.06691917,0.111831464,0.025762059,0.02173038,0.00661387,-0.010578156,-0.0276865,-0.052978333,-0.01950801,0.012529871,0.08312266,-0.03559367,-0.028296847,0.047661234,0.028581025,0.05228172,-0.039027397,-0.044488277,0.05547297,0.0019102433,-0.037595168,0.055253703,0.025348274,-0.030126505,-0.04106658,-0.017892467,-0.022848088,-0.046162352,-0.03921999,-0.012692844,0.08707524,-0.026664838,-0.06619328,-0.016911607,0.020624686,0.0626373,-5.4564e-33,0.08151755,-0.05832795,0.051376097,-0.071512334,-0.016647814,0.0010079351,0.060360864,-0.015581645,0.0506218,0.00018132245,0.015741093,0.009918804,-0.0050343215,0.015031898,-0.007870424,0.0074488195,0.01513061,0.04726887,0.023451926,0.03169431,0.008535443,0.051908307,-0.02760771,0.0043449467,0.07755792,0.05483647,-0.0005400798,0.030937703,0.0046736677,0.060465973,0.010575494,-0.006105635,-0.02226322,-0.020506112,-0.042191,0.050017748,-0.08472222,-0.057948828,-0.036605917,0.07687562,0.030562896,0.023299068,0.01926967,0.022170322,-0.026651109,-0.028046742,-0.09954484,0.0032405616,0.018203147,-0.08905268,-0.030833513,0.05062354,-0.028864896,-0.0064187343,0.08361524,0.07080355,-0.01632515,0.0004502662,0.00668254,-0.024315549,-0.0012963915,-0.082205996,0.0017833444,-0.0049687214,0.06634523,0.07605592,-0.018581219,0.07279409,0.014401065,0.039453298,0.1131989,0.01802131,-0.011834823,-0.0035330353,-0.035098188,-0.026430734,-0.05921432,-0.065953515,-0.027518595,-0.05894686,-0.025023138,-0.0028371287,0.00075339666,-0.07854027,-0.061354935,-0.10289687,0.0027324602,0.12208453,0.015838146,-0.008398653,0.029818075,-0.013852884,-0.0028538504,0.029120741,0.12668097,-4.6266635e-08,0.035754636,-0.11088297,0.089226685,-0.022937225,0.0012961513,-0.060246136,0.052817542,0.036436148,0.012747097,-0.051330037,0.00494926,0.022447698,0.06454734,-0.022599017,0.06676062,0.05292983,-0.004071274,0.07627207,-0.046626605,-0.025022145,-0.044407666,-0.016705628,-0.121445775,0.02354859,0.04469613,-0.041376624,-0.0010212366,0.00926722,0.007851842,-0.027836513,0.034994155,0.0044607986,0.007506507,-0.08368837,-0.10730237,0.01845553,-0.050765935,-0.042839006,-0.031054907,-0.066162504,-0.03376152,-0.035521626,-0.018625239,0.071065955,0.021225387,0.036645778,-0.01955264,0.0022449256,-0.015172031,0.015040467,0.036745198,-0.03388258,-0.003498306,-0.09271872,-0.09430116,0.037724487,-0.036266338,0.010669907,0.034730103,-0.083574966,-0.024368247,0.064351365,0.23243709,-0.110488236 +2.7.1.160,"Catalyses the final step of tRNA splicing in the yeast Saccharomyces cerevisiae [2]. The reaction takes place in two steps: in the first step, the 2'-phosphate on the RNA substrate is ADP-ribosylated, causing the relase of nicotinamide and the formation of the reaction intermediate, ADP-ribosylated tRNA [6]. In the second step, dephosphorylated (mature) tRNA is formed along with ADP ribose 1''-2''-cyclic phosphate. Highly specific for oligonucleotide substrates bearing an internal 2'-phosphate. Oligonucleotides with only a terminal 5'- or 3'-phosphate are not substrates [1]. ",384,1.0,-0.017653013,-0.08504738,-0.047824163,-0.10575751,-0.016387094,-0.09464537,0.00014161385,-0.034477115,0.01224995,0.060114074,0.0727383,0.047107894,-0.09708517,0.005332216,-0.06271278,0.04010177,-0.109904185,0.013973889,0.09008592,0.02654388,0.069312334,0.074222416,-0.024599632,-0.012785729,0.035608783,0.009502917,0.06192853,-0.04642975,0.002378923,-0.03157828,-0.04783351,-0.04184849,0.019644512,-0.032781396,0.004712043,0.08695148,-0.038897984,0.009402391,0.046612713,0.04447701,0.052169263,0.0022692943,-0.05742336,0.017861042,-0.0618035,-0.035458855,0.006659446,0.05211119,-0.051158246,0.021033285,-0.052304845,0.028479509,-0.03242315,-0.060653016,-0.011818442,0.08717419,-0.032896075,0.02963958,5.6032015e-05,0.0034758623,0.024799693,-0.031873833,-0.04546528,-0.021524021,0.14760166,-0.09858221,0.14889704,-0.0063396445,0.012267287,0.027250977,-0.005536045,-0.0027580324,-0.053349096,0.016217513,0.006561103,0.070487395,-0.013072258,-0.043111477,0.02122381,0.021525633,0.019466352,-0.011508467,0.040069506,0.046129905,0.01743413,-0.02000202,-0.023183074,0.093163006,0.06417363,0.039134745,0.010076172,0.04093547,0.04869592,-0.01098807,-0.064214446,0.084456146,-0.0056258496,0.07860758,0.017103318,-0.061301775,0.006790768,0.07691567,-0.011329379,-0.006300428,0.03450398,0.040537704,0.0067702453,0.06439477,-0.04911749,0.10360864,0.03925081,-0.001483302,0.08287862,-0.08705553,-0.0113761835,0.06616032,-0.03532277,-0.017287461,0.034849558,0.0057227337,-0.05130291,0.073794276,-0.030581566,0.0535933,-0.08158283,0.038790938,-0.05830589,3.498439e-33,0.041806925,0.04831794,0.020660259,0.03005599,0.01078639,0.033573095,-0.078825995,-0.039328214,-0.10653547,0.005434417,-0.023946365,-0.09446381,-8.754529e-05,-0.0023299356,0.01537204,-0.07204677,-0.0060675964,0.061798356,0.015207938,0.024438621,-0.0105281025,0.03646055,-0.026044155,0.02861592,0.06352782,-0.011814221,-0.05349186,0.034731846,0.0033785973,-0.02409229,0.04279044,-0.034329716,-0.105747804,-0.029262505,0.112201706,-0.07447265,0.0021903904,-0.005633088,-0.041149274,0.060578063,-0.007361299,0.010802535,-0.00028327722,0.0200098,-0.0103233745,0.0014281218,-0.0197489,0.011770745,-0.0022325872,0.031173466,0.020718722,-0.06045593,0.063558534,-0.016494468,-0.022046315,-0.007441135,-0.010479924,-0.067277454,0.08147346,0.07542617,-0.04848625,0.029134795,-0.0025223664,0.08257422,-0.06597805,-0.029389124,-0.048117615,-0.10933286,0.03512138,0.02113714,-0.05046052,-0.0130689265,0.078613,-0.026265673,-0.010880386,-0.0273704,-0.060215216,-0.058697954,-0.08020962,0.055594526,-0.011837415,-0.07391224,-0.029477185,0.008193189,0.023541547,-0.02753286,-0.0040586656,-0.043971404,-0.030200675,0.055705853,-0.001391787,-0.033458523,-0.036668707,-0.0010219652,0.04892483,-4.3509884e-33,0.09047533,-0.056321986,0.093177356,-0.071750745,-0.15564552,0.08422129,0.035262384,-0.11281115,0.003708037,-0.10184747,-0.0062149456,0.007198443,0.018012106,0.014873622,-0.02834873,-0.019794337,0.035204366,0.08496553,0.003021453,-0.040114187,0.075157315,0.077219985,-0.08135363,0.09317633,0.06943873,-0.04793583,0.03201318,0.07723971,-0.004988294,0.021817932,-0.007884313,0.020181235,0.01907631,0.054661915,-0.05179925,0.054715436,-0.025365675,0.036210373,0.031938303,-0.002305258,-0.010709477,0.052486777,-0.05085065,0.04866075,-0.034849584,-0.0033205124,0.0013035485,0.0015062506,-0.04950945,-0.080333255,0.07471512,0.020492366,-0.037039362,0.026357612,0.06942661,-0.010911912,-0.038612504,0.021366235,0.04883536,-0.032115944,-0.014941016,-0.0336831,0.00043669142,-0.06699113,0.080973245,0.040947482,0.002090849,0.024312632,-0.0064968504,-0.096432246,-0.023270255,0.049776454,0.008352672,0.024764223,0.048048362,0.0064422945,-0.10839507,-0.025628362,0.036420833,-0.03324309,-0.04700535,-0.037366062,0.042863525,0.03071907,0.02807982,-0.057217102,0.03963098,0.067461625,-0.04709163,0.053366084,0.013512631,-0.0117044225,0.03646006,0.044242516,0.018273104,-4.2411934e-08,0.03427499,0.02445341,-0.017527286,-0.05960593,0.02908342,0.066102184,0.0230961,0.039652,0.079161294,-0.009665228,-0.06117198,0.035284985,-0.00198842,0.0963436,0.11142491,0.033246163,-0.12803687,-0.028169833,-0.05107501,-0.05558644,-0.07007267,0.042379104,-0.15888709,0.07023334,-0.06776969,-0.005295264,0.05535151,0.058713533,0.07567823,-0.04905793,0.034361668,-0.027892161,0.009663165,-0.044317275,-0.06415063,-0.011260942,-0.008501153,-0.039949678,-0.023693636,0.045021825,-0.04130434,-0.06371384,-0.03743878,-0.002529402,-0.09124202,0.018716943,-0.0072663696,0.0786556,-0.06954825,0.005041432,0.08582752,0.049709845,-0.014233846,-0.042956527,-0.05168913,-0.06146548,-0.046363298,-0.020611268,-0.03904843,0.030243676,0.008979073,-0.011653462,0.09054628,-0.08641805 +2.7.4.23,"This enzyme, found in NAD supression mutants of Escherichia coli, synthesizes 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) without the participation of EC 2.7.6.1, ribose-phosphate diphosphokinase. Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor.",384,1.0,-0.062355835,-0.04499161,-0.045144018,-0.06233293,0.009222264,0.02676287,0.0046028914,0.029524744,0.05089651,0.07573021,0.023627456,0.03853501,-0.0315205,0.059564095,-0.031660914,0.007244201,-0.01112581,0.00027609325,0.05985303,0.03165566,0.08159666,0.050473336,-0.03608578,-0.022545857,0.046982843,0.0027903318,0.051977575,-0.013953002,0.00044922056,-0.048648115,-0.111365326,-0.04361035,0.00032833233,-0.052371223,0.07956353,0.112341516,0.009930539,-0.05589707,-0.010375061,0.039301563,0.01545968,-0.018615494,-0.05155918,-0.0139778,-0.008459287,-0.028298367,0.01597498,0.10463015,0.00023239145,-0.081606984,-0.06729715,-0.07253479,-0.0045366725,-0.08266575,0.042095788,0.013161386,-0.021912588,-0.0663097,-0.012268632,-0.04182123,-0.032690663,-0.020275068,0.004773483,-0.016739849,0.087375864,-0.058616813,0.082737476,-0.02162433,0.008258806,-0.016517384,-0.120549046,0.0051812725,0.046886694,0.03006956,0.017891722,0.05959873,-0.02309416,-0.005562586,0.05590404,-0.017647242,0.050821647,-0.048139066,-0.032316994,0.026616577,-0.0216831,0.03061231,0.010585066,0.067934975,0.04368036,-0.0032377457,-0.0574197,0.019389216,0.03418791,-0.011022488,-0.116773665,0.03691446,-0.08464436,-0.0015527181,0.0067006033,-0.068350345,0.018325234,0.13683711,0.056246467,-0.06631584,-0.021439333,0.007553104,-0.064985946,0.10891246,-0.024100164,-0.020451205,-0.003709257,0.016688516,0.022936618,-0.05829734,-0.030190278,0.08842273,-0.071004674,-0.0892956,-0.08711737,-0.047717128,0.0053465413,-0.031258237,-0.042118546,0.089776516,-0.080973595,0.020147724,-0.10170869,1.5617328e-33,0.10127717,0.07863678,0.05223428,-0.00831242,0.025473278,0.043296807,-0.088043965,-0.039742522,-0.058722857,-0.0041607437,-0.05291598,-0.11272852,0.06846063,-0.04461017,0.01959686,0.016674353,-0.05660732,0.060819168,0.010788642,0.03339131,-0.0017022109,0.06532423,-0.008114706,-0.0069163446,0.028728321,0.1036913,-0.07776465,-0.028219901,0.05664808,-0.016807709,0.07617066,-0.020991031,-0.112900026,0.009189401,0.047631595,-0.13452394,-0.019410066,-0.048766777,0.024018982,0.05956985,-0.02362133,0.024399517,0.0071371766,0.00083022704,0.098173656,-0.123011686,0.00035974017,0.03981524,0.009340845,0.051395472,0.033329353,-0.006011508,0.07625587,-0.04072001,-0.03287842,-0.022653475,-0.0063591744,0.0036558583,0.049850993,0.043936376,0.0023380038,0.027182378,-0.073354766,0.012726405,-0.031835124,0.011547765,-0.06549449,-0.107843526,0.060875285,0.15835333,0.0047705015,-0.017053086,0.015283204,0.008641537,-0.0019207109,-0.11412635,-0.01992536,0.05364917,-0.016132396,0.025781063,0.015852457,-0.05475769,-0.083840474,-0.008676075,-0.018310882,0.014021742,0.048261818,-0.057029136,-0.010431558,0.07904953,0.05139441,-0.04853374,-0.05285193,-0.016166577,0.025986549,-2.3339495e-33,0.113333724,-0.05994297,0.019288693,-0.061264884,-0.07938297,0.019910738,0.02811044,-0.062320687,0.054776922,-0.0742261,0.052960917,0.051871907,0.08705226,-0.014176536,-0.03920556,0.012417711,-0.0062501915,0.019126179,-0.030179491,-0.029688373,0.045917403,0.08321477,0.055854328,0.0752702,0.05514822,-0.044050023,0.0012536051,0.07750508,0.023327231,0.021046175,0.0049232184,0.02806987,-0.068639345,-0.0046461932,-0.055475175,-0.0037872773,-0.027052317,0.07869527,0.04755028,0.041973602,-0.046271343,0.050739788,-0.0029781891,-0.014866455,-0.010702964,0.110255845,-0.00026240895,-0.019783024,0.022183172,-0.061230667,0.021973385,0.018020066,0.021502102,0.0119943805,-0.00096051506,-0.021525206,-0.05216001,0.06034406,0.020215861,-0.017792178,-6.184892e-05,-0.06831716,0.032348502,0.0058067734,0.087288715,0.070823886,0.05312467,0.026568964,0.04461977,-0.026059695,-0.0033887958,0.0420664,0.020679789,0.01521702,0.034160808,-0.011387441,-0.10342681,0.009491325,0.023213904,-0.035549574,-0.0047742403,0.032000612,-0.037574567,-0.054019447,0.060156364,-0.01816078,0.053983826,0.11764177,0.025407603,0.033198293,-0.07583875,0.05513976,0.02785071,0.010060543,0.075672135,-3.7353452e-08,0.02524992,0.0066140452,-0.0060301246,-0.061945215,0.033903975,0.018525325,-0.0075005493,-0.025183149,0.07100943,0.027000232,-0.035883706,0.10241779,0.05667412,0.011796357,0.057484798,-0.006458327,-0.05954425,-0.0006149263,-0.024285946,-0.025387162,-0.03734153,0.028938744,-0.1025584,0.09453844,0.007234751,-0.037271854,0.0789284,-0.062322706,0.047290575,-0.037091676,0.009230243,-0.0005205823,0.031900316,-0.077912785,-0.060553607,0.065946914,-0.037364002,0.044211656,-0.028471155,0.032651108,0.0064321384,-0.066760495,-0.041735593,-0.021997295,-0.07931156,0.04075579,-0.003192764,-0.020295367,-0.039350517,-0.017123919,0.05627489,0.021314489,-0.05030473,-0.07871519,-0.08514173,-0.014987141,0.0011260264,-0.055627014,0.016093304,-0.048385803,0.044270553,0.0061618877,0.10341346,-0.057559397 +3.1.1.80,"This plant enzyme is responsible for the last stages in the biosynthesis of the indole alkaloid ajmaline. The enzyme is highly specific for the substrates 17-O-acetylajmaline and 17-O-acetylnorajmaline as the structurally related acetylated alkaloids vinorine, vomilenine, 1,2-dihydrovomilenine and 1,2-dihydroraucaffricine cannot act as substrates [2]. This is a novel member of the GDSL family of serine esterases/lipases.",384,1.0000001,-0.06337283,-0.045641195,-0.06275134,-0.037835754,-0.020453654,0.08119342,-0.08811875,-0.01082508,0.050722294,-0.053050373,0.033708647,-0.009422443,-0.053037092,-0.032986462,-0.052486148,0.039558046,-0.025687762,0.06969708,-0.04085127,-0.07073572,0.055573557,0.027391253,0.037391353,-0.09275334,0.039168034,0.05787337,-0.0032447502,-0.039304968,-0.03405546,-0.05972885,0.05766885,-0.02637132,0.03196898,-0.032964595,0.03650377,-0.03195067,-0.008064255,0.04277059,0.10700786,0.05359893,-0.035804622,0.022304732,-0.11628301,-0.0128782485,-0.022248417,-0.09036419,-0.0008060112,-0.042282555,0.0503933,0.0029301331,-0.06955109,-0.05424884,-0.008366901,-0.009499622,0.012379787,-0.08485385,0.006681728,0.08370745,-0.026884329,0.070003726,0.08967863,0.041695226,-0.021303328,-0.044371486,-0.07384227,-0.07239114,0.025758702,-0.047494777,0.06281951,-0.06393296,-0.042589404,-0.071041755,-0.016243353,0.030436583,-0.07964789,0.082854174,-0.023047907,-0.035224866,0.030727439,-0.017424373,0.029359398,-0.010636344,0.015104425,0.065059364,-0.029569142,-0.002028249,0.04175841,0.056628764,0.11512247,0.05995851,0.02539897,-0.034942035,-0.045366,-0.036231596,0.013949084,0.023674106,0.043282643,0.005095086,-0.02461857,-0.015399904,0.03432391,0.0168803,-0.024561185,-0.023762481,-0.056079585,0.018371886,-0.04975582,-0.019464485,-0.02851974,-0.054021105,0.012154767,-0.009708072,0.015074571,-0.00015665522,-0.057717603,0.0748213,0.009529452,-0.025031246,-0.029918728,0.0020471949,-0.001125071,0.009906079,0.08131119,0.09882375,0.0114368955,0.04532832,-0.06621518,4.0683724e-33,0.04903006,0.048065275,0.0013270901,-0.024011215,-0.015142349,-0.08515797,-0.08472131,0.036758542,-0.034718823,-0.054381277,-0.06370546,-0.08140302,0.043577377,-0.025594123,0.02779195,-0.0070865233,-0.049445264,0.0036905785,0.068030864,-0.042705007,-0.046732426,0.019906318,-0.034627125,0.030100659,-0.05616795,-0.0029074668,0.03685766,0.034476254,0.037721746,-0.0049765985,-0.007261068,-0.1238959,-0.024607645,-0.0017607956,0.0070103207,0.052829556,0.0024320672,-0.021158144,-0.002102945,-0.005843956,-0.004972355,0.074949965,0.06281102,0.068594754,0.0032540176,0.0064547616,-0.09622606,0.073288985,0.056865793,0.037674762,-0.074788585,-0.017034436,0.10296235,0.025756696,-0.0023868892,0.09522772,-0.034121204,0.016557835,0.03358606,0.054195058,-0.019389777,-0.010378334,-0.03788882,0.038161166,0.042641222,0.011731932,-0.07803998,-0.071959674,0.012308406,0.098181054,-0.030129502,-0.026940519,0.028485756,0.053439334,0.0351325,-0.031738926,0.051354453,0.0030540738,0.002928638,0.010586509,-0.0056504193,0.021604143,0.008795655,-0.02285453,-0.01952636,-0.010843432,-0.08369295,-0.011149519,0.0106367,0.12294344,-0.006557061,0.016344937,-0.09832717,0.10297011,0.022627514,-4.563852e-33,0.074362986,-0.06773998,0.05435616,-0.05051759,-0.080918595,0.0796738,-0.031236561,0.07990297,0.008381826,0.06104623,0.019452514,-0.017763257,0.077297114,0.012994091,-0.08148451,-0.0712558,0.019809311,0.06572946,0.00927751,0.06493356,-0.06304907,0.10108314,-0.025832571,0.06464557,0.03637271,-0.007903695,-0.037711818,0.051148795,-0.10957922,0.081778385,0.117527395,-0.051316097,-0.041043866,-0.01042811,0.006919308,0.103726916,0.026455967,-0.010149325,-0.026484894,0.106103696,-0.08527411,0.040959068,0.02353256,-0.0046037245,0.048190985,-0.01513239,-0.00013369622,0.068112254,-0.049506918,-0.13559799,-0.014541309,0.01306666,-0.0013074571,0.0059337113,0.075017184,0.03428402,0.05640202,0.02296032,-0.0024218108,-0.019230407,0.047430445,-0.056904953,0.011328307,-0.04079564,0.027484097,0.08839048,0.020476019,0.045144655,0.060730275,-0.032815345,0.009945453,-0.027685434,0.028325142,0.101144135,0.029998554,-0.06209613,-0.03129077,-0.03919018,-0.043808054,-0.058745176,0.06965728,0.033870753,0.0014777626,-0.10753587,-0.015688151,0.034802217,0.010982411,0.1291334,0.017440576,0.037883107,-0.0050768396,-0.0018899501,-0.13589208,0.085525714,0.046012793,-4.018935e-08,0.00337915,-0.057255004,0.060850672,-0.033611566,-0.07359117,-0.00054686284,0.035046205,-0.03648814,0.054142796,-0.09210473,-0.01215161,0.084789224,-0.02942431,0.06303474,-0.02523363,-0.022602042,-0.028113743,0.07562999,0.012939188,0.038885746,-0.0101226065,0.024575718,-0.031164208,-0.046684157,0.010029135,-0.11530542,0.027669257,0.05547445,0.034988474,-0.023534713,0.025989668,0.016015843,-0.007940127,-0.08650871,-0.06787281,-0.00992334,-0.02331445,-0.012468683,0.020909712,0.053021174,-0.011509813,-0.050515924,-0.06368029,0.002333379,0.037575483,-0.0007630793,0.026338335,0.027266303,-0.01448824,-0.060137674,0.007323172,-0.017942797,0.04543447,-0.06365855,-0.0836964,-0.054348588,-0.076853395,-0.056790683,-0.022148896,-0.104016155,-0.02108755,-0.030870903,0.12517336,-0.037801933 +3.1.3.77,"This bifunctional enzyme first enolizes the substrate to form the intermediate 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate, which is then dephosphorylated to form the acireductone 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one [2]. The acireductone represents a branch point in the methione-salvage pathway as it is used in the formation of formate, CO and 3-(methylsulfanyl)propanoate by EC 1.13.11.53 [acireductone dioxygenase (Ni2+-requiring)] and of formate and 4-(methylsulfanyl)-2-oxobutanoate either by a spontaneous reaction under aerobic conditions or by EC 1.13.11.54 {acireductone dioxygenase [iron(II)-requiring]} [1,2].",384,1.0,-0.10088573,-0.028285364,-0.04862508,0.0017905709,0.06879471,0.008113634,-0.08820097,0.07031331,0.00927097,-0.03536675,-0.005712306,-0.018674538,-0.0512508,-0.020902114,-0.018372973,0.055892654,-0.05132911,0.014554717,-0.011037618,-0.037712112,0.050500356,-0.016641734,-0.063619055,-0.054993466,0.043445017,-0.04387527,0.07315179,0.048373736,-0.035707932,-0.073576346,-0.038057093,-0.05527635,0.0122659905,-0.011798373,0.02267546,0.10956482,-0.026545705,-0.040768858,0.032318402,0.022507232,0.088441186,0.013075922,-0.013874679,0.01139948,-0.0026033972,-0.0154462885,-0.028120603,0.044821255,-0.009559968,0.030095797,-0.062565185,-0.014259584,0.011613818,0.026326632,0.01038746,0.005229991,0.030981528,-0.02395028,-0.055030826,0.016021281,0.011090448,-0.039789576,-0.067062296,-0.058002893,-0.003626756,-0.06307029,0.06916002,-0.058483668,0.092930295,-0.046543285,-0.049522683,-0.0001910242,0.009546716,-0.03642754,-0.04302464,0.041045673,0.0004618669,-0.034934293,0.045752082,-0.0730061,0.058261912,0.07304315,0.07857549,0.058587443,0.07997074,-0.008444841,-0.019762527,0.0054199905,0.06433183,0.0828767,-0.07006881,0.041034512,-0.09225838,-0.024938116,-0.013692169,0.06951465,0.062973626,0.11100385,-0.033199325,0.022721179,-0.029016895,0.11790469,-0.05872691,-0.10079716,-0.08552647,-0.044204433,0.041407138,0.087856755,0.014180887,0.038523212,-0.00031023394,-0.046706513,0.04634384,-0.0062751533,-0.003943533,0.12291979,-0.023144914,-0.058404453,-0.029479614,-0.011917835,-0.0025075537,0.026995312,-0.0054190736,-0.012466024,-0.07420386,-0.028896207,-0.043637924,3.410352e-33,0.06575002,0.070682384,-0.04458623,0.06344554,-0.024736699,5.6233188e-05,-0.16892263,-0.0154879335,-0.06189481,-0.037360165,-0.0069204518,-0.057564862,0.057729416,-0.043758977,-0.055876873,-0.058282327,0.014418064,0.0131851295,0.023479752,0.0008332291,0.02941097,0.051055335,-0.100540325,-0.00037384316,-0.0412423,0.008784496,0.0050113313,0.009231926,0.016888237,-0.0041111326,-0.014968441,-0.035667412,-0.08335505,-0.0007524706,0.057805758,-0.008880822,-0.06075593,-0.035173927,-0.029015724,0.06438845,0.039299663,0.04648138,-0.0049596755,-0.03757722,0.0762186,-0.08083861,-0.09151598,0.16421226,0.08928836,0.07735496,-0.007567581,0.04047619,0.16810091,-0.040275693,-0.1135014,0.04870022,-0.028928284,-0.06204786,0.06617464,0.020251105,0.011777494,0.078487724,-0.013285664,0.07349371,-0.016422445,-0.0010151176,-0.09195354,-0.05308343,0.050567105,0.07553019,-0.015208995,0.002982027,0.012885444,0.010326741,0.035523105,-0.04162364,0.020029614,0.033791512,0.014099448,0.03706489,0.04580475,0.0015615801,0.011144604,-0.057689704,-0.026126578,-0.002501697,0.004355762,-0.0080132885,0.018566113,0.032199033,0.06999093,-0.03187416,-0.06219395,0.0026828307,0.04297488,-3.22863e-33,0.08574,-0.034856383,0.03613998,-0.092706904,-0.07137846,0.08050337,0.008057521,-0.03967464,0.0062594004,0.029229853,0.12926279,-0.018357024,0.010828293,-0.07937272,0.033919286,0.0080585005,-0.04046293,0.096113436,0.06649155,0.02571571,0.09187091,0.090292595,-0.02705987,0.05280898,0.05771527,0.022100246,-0.019396218,0.061731644,0.03040865,0.09339929,-0.007884949,-0.013732178,0.017561266,-0.0079209665,-0.006849553,0.052179262,-0.0640274,-0.021460008,-0.023157323,0.07412606,-0.020850295,0.023647923,-0.01242533,0.07307581,0.056855306,0.042922925,-0.10517375,0.019617138,0.0019006849,-0.065759204,0.053774524,-0.052565653,-0.11109487,-0.026276391,0.033539556,0.04958716,-0.024888055,0.04825214,-0.021966351,-0.056847025,-0.014689136,-0.03142955,0.04891045,0.013683699,0.032198094,0.009797183,0.031377535,0.0569524,0.037840083,0.039088633,-0.042239618,0.082570575,0.071154505,-0.02114323,0.03725504,-0.04368666,-0.03548389,0.06939919,-0.071233794,0.008965758,0.02673371,-0.00575654,-0.009060466,-0.032831833,-0.026543586,-0.042908385,0.022858532,0.11562714,-0.023429045,0.03372572,-0.06440401,-0.0037990075,-0.07235067,0.0771525,0.008264633,-5.741917e-08,0.027654963,-0.06430753,0.09627023,-0.022607345,-0.038849656,-0.010053609,0.050713338,-0.05423966,0.087463014,0.0044687493,-0.010834207,0.058990005,0.024393303,-0.04224607,-0.025334656,-0.013300392,0.0033681786,0.03708538,-0.04884124,0.0106763905,-0.09076264,-0.008283977,-0.034851085,0.02320613,0.036075924,0.0008969818,-0.011556763,-0.007998289,-0.025149358,-0.034282774,0.016467877,0.03513985,0.029745597,-0.06055899,-0.15073133,0.012258725,-0.045468185,0.002495872,-0.047886126,-0.0077989814,-0.010569964,-0.025680942,-0.042196214,0.0689119,0.048439454,-0.058804065,0.01831776,0.036994353,-0.058857407,-0.03463778,-0.023514211,0.0016525318,0.031841625,-0.056729034,-0.092409395,0.025758117,-0.026067125,-0.020269232,-0.014888821,-0.04783423,-0.012664556,0.018637598,0.101618744,-0.05067696 +4.2.1.109,This enzyme forms part of the methionine-salvage pathway.,384,1.0,-0.06475387,-0.042402156,-0.03219408,0.05909308,0.039971508,0.020884776,-0.07468944,0.047079023,0.018665045,-0.025044842,-0.004409353,-0.037114087,-0.019055773,0.040379487,-0.026832886,0.03240368,-0.10349863,0.015720874,0.02647842,-0.014789547,-0.00010788244,0.10067217,-0.010207025,-0.06278348,0.09364661,-0.025005624,0.036053028,0.025477082,0.016806224,-0.027194409,-0.0016003111,-0.016938472,0.042917896,0.011005398,0.056436587,0.15469022,-0.04183559,-0.0014731849,0.04823409,-0.018668447,0.09009861,0.0021730398,0.02020126,-0.03891892,0.057185296,-0.028893758,-0.02414164,0.01740883,0.07319687,-0.021261835,-0.10831529,-0.05899829,-0.008281764,0.06887552,0.060671907,0.08234187,-0.0019499299,0.014109879,-0.00487601,-0.0007925657,0.03725479,-0.04403367,-0.02538435,-0.05506976,0.05835351,-0.09288734,0.021651715,-0.046766292,0.11350772,-0.017406957,-0.020662181,-0.043351177,-0.014122585,-0.041827694,-0.07357508,-0.016201051,-0.038583193,-0.03051072,0.05835696,-0.030403458,0.061309915,0.027842784,0.05115033,0.033042856,0.050694384,0.058561232,0.002359367,-0.033418,0.06519659,-0.024237903,-0.09651548,-0.036896765,-0.046826858,-0.07858633,-0.051126678,-0.00018304746,0.038807757,0.06634079,-0.028553328,0.038434558,-0.004156841,0.014673156,-0.07103718,-0.10494711,-0.1203128,-0.022899581,0.05524588,0.07534794,-0.0047427877,0.04158667,0.066756144,-0.013275407,0.07442202,0.018263487,-0.008537635,0.13062766,-0.029250875,-0.049813315,-0.03238281,0.06418961,-0.0005655007,-0.03237457,0.121122785,0.00875556,-0.020138318,0.009215081,-0.034237698,-2.828158e-33,0.054018524,0.036983375,-0.02214621,-0.023545653,0.04909191,-0.03031532,-0.073906444,-0.0044380375,-0.058842998,-0.11409494,-0.041342728,-0.04964463,-0.015028298,0.007928,-0.10488851,-0.06762213,-0.011737516,0.028184984,0.023383321,-0.029635292,-0.022696499,-0.015026495,-0.039212164,0.022069408,-0.00045454488,-0.036564723,-9.118605e-05,0.059854448,0.03282751,-0.001258837,-0.046087854,0.028194528,-0.077469416,0.056392744,0.011832689,0.08868568,-0.09662389,-0.04542736,0.004554632,0.05601386,0.03709914,-0.015985353,0.0036144124,-0.048285272,0.032630138,-0.024715332,-0.07602709,0.05468326,0.02319582,0.057975788,0.038136076,-0.046309095,0.14514184,-0.053201877,-0.15024135,0.0064126705,-0.032172795,-0.08413805,0.035711147,0.07823363,-0.02500122,-0.014948172,-0.05189741,0.11825879,0.02204485,0.016097704,-0.043155894,-0.004200291,0.028859388,0.1019495,-0.025187403,-0.026509576,0.019311285,0.06930496,0.003300766,-0.014776789,-0.051350802,0.060571328,0.011304336,-0.019892812,0.025017258,-0.045203786,-0.02459104,-0.02511231,-0.012103395,0.01829442,-0.01888731,-0.07320267,0.0048470916,-0.0022778907,0.023094073,-0.0621595,-0.064490125,0.0187125,0.029116653,1.9796792e-33,0.07313705,-0.03944806,0.026520919,-0.063389964,-0.09834917,0.072733045,-0.00048804074,-0.063254304,0.05795917,-0.0069575277,0.07481241,-0.045200497,0.017748512,-0.052656796,0.0053458116,0.01421299,0.013266253,0.072698176,0.033982925,-0.010871446,0.08610665,0.02822305,-0.04554847,-0.00343138,0.060082633,0.0055149463,0.019972082,0.06718195,0.016262244,0.067644075,-0.028113432,-0.032911163,-0.07832136,-0.0021938053,-0.023482356,0.0702919,-0.03879797,-0.033583224,0.023367004,-0.035899613,0.007651844,0.04075715,0.010938652,0.101886004,0.0709403,0.0034940648,-0.0006960934,0.016571715,-0.055751383,-0.118333206,0.057980396,-0.057666816,-0.011072482,-0.025268115,-0.05068775,0.12850405,0.0039059913,-0.0030550165,-0.045023516,-0.073320925,-0.022650996,-0.019434564,-0.009422593,0.04597686,0.07215171,0.0042650546,0.05904604,0.03983832,-0.0231278,-0.02125408,0.03021108,0.041874796,0.074100755,0.0831623,-0.026090698,-0.03683477,-0.12428284,0.06835865,0.01865503,-0.026704293,-0.027480405,-0.03011312,-0.0065122014,-0.05592101,0.013122556,-0.047121003,0.0012524148,0.09483608,0.061800607,0.049700737,-0.10000736,0.027277736,-0.04674658,0.009979655,0.009978384,-1.897352e-08,0.10236026,-0.09954738,-0.014427323,-0.0023300108,0.03622331,0.010944108,0.0006083061,0.018050166,0.04545887,0.012398394,-0.091528274,0.071175314,-0.018011834,-0.0004104845,-0.05374588,0.04581644,0.022863507,0.06203229,-0.064834885,0.00025392743,-0.06039352,0.00263903,-0.015689455,0.06912772,0.020274272,-0.035243336,0.0031938395,0.124458134,-0.05161445,-0.06723635,0.013510325,-0.016984414,0.014188441,-0.041864622,-0.12002138,0.015202241,-0.010773309,-0.059151813,0.00016341517,0.008534905,0.047761228,0.018776963,0.010972201,0.012405693,-0.0048927236,-0.0030570743,-0.04811049,-0.0038582038,0.0034031966,0.01107242,0.027264476,0.035913564,0.032041308,-0.028857088,-0.08676881,-0.021145876,0.028065916,-0.002684276,-0.016130688,-0.019458605,0.028901156,0.054390226,0.16793534,-0.029433727 +4.2.2.20,"This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1-3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [5]. The related enzyme EC 4.2.2.21, chondroitin-sulfate-ABC exolyase, has the same substrate specificity but removes disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments produced by EC 4.2.2.20 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+4.2.2.21,"This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. The related enzyme EC 4.2.2.20, chondroitin-sulfate-ABC endolyase, has the same substrate specificity but produces a mixture of oligosaccharides of different sizes that are ultimately degraded to tetra- and disaccharides [4]. Both enzymes act by the removal of a relatively acidic C-5 proton of the uronic acid followed by the elimination of a 4-linked hexosamine, resulting in the formation of an unsaturated C4---C5 bond on the hexuronic acid moiety of the products [4,6].",384,1.0,-0.03631146,-0.08770058,-0.03496665,-0.013415063,-0.011471561,0.023586156,-0.07387088,0.03947,0.0035735432,0.06242076,0.02931894,0.06523833,-0.021751054,0.040758237,-0.09451921,-0.0036795433,-0.020345347,-0.017718393,0.0031723941,-0.059846226,0.09195321,-0.06925665,-0.05758926,-0.0469506,-0.017142585,-0.02635268,0.032158844,-0.030368384,-0.07441947,-0.08654926,-0.05692449,-0.05603831,-0.027197242,-0.04033234,-0.0079731345,0.12140042,-0.056199193,-0.041434366,-0.0031078365,-0.041109424,0.025258698,0.0040537384,-0.01997616,-0.015810715,0.014337753,-0.14251237,0.027088106,0.0041788258,0.04556575,0.00435596,-0.025569657,-0.034912523,0.015534663,0.01584557,0.04261315,-0.0007553687,-0.119660236,-0.016344516,0.07699021,0.04027196,0.019802224,0.04974471,-0.01522763,-0.07953304,-0.018245256,-0.05839478,0.074789196,-0.068740964,-0.07067853,0.082098484,-0.07479972,0.034274165,0.024572253,0.04077612,0.06556858,0.037575413,-0.054321095,-0.033793148,0.024612404,-0.02109876,0.031291258,0.06672929,0.009963034,0.10524346,-0.012567152,-0.04818656,0.017660601,-0.028655807,0.04833354,0.02161598,0.036317796,0.013957583,-7.370588e-05,-0.028483264,-0.011854701,-0.06979724,-0.003881503,0.08164679,0.019998753,-0.03198338,-0.011974892,-0.019333791,-0.005670943,-0.10464833,-0.02627716,0.04394381,-0.019335827,0.11642805,0.12474603,0.05920087,-0.005484242,0.008348152,-0.026960881,-0.07112212,-0.093115546,0.136676,0.024747549,-0.032304574,-0.057121683,0.019158259,0.008525836,0.03346276,0.07146268,0.053332675,-0.0028314062,0.010063945,-0.021836838,2.564372e-33,0.07506863,0.0017864862,0.058201853,-0.010535696,0.015859243,-0.012310596,-0.041473474,0.0541045,0.005683895,-0.013405561,-0.06850338,0.036787204,-0.03121451,0.058637377,-0.020369466,0.059856888,0.0069167623,-0.052996643,0.022084402,0.010329272,0.00099938,0.08189004,-0.041369975,-0.0343985,0.048233498,-0.016363522,-0.035410795,0.03343685,0.043680623,0.0016994037,0.06594284,-0.072701395,-0.04954415,-0.016817903,0.07492632,0.017373549,-0.022613628,0.020493696,0.0074779657,-0.02351992,0.05333095,0.017896311,0.025436575,-0.064021535,0.038575143,-0.09917664,0.06836281,0.04816789,-0.0022278226,0.03485093,0.05785794,-0.007668915,0.075839095,-0.0040949066,-0.098588556,0.057732876,-0.0017158118,-0.027260419,0.04372678,0.07991686,0.029937081,0.015162575,-0.027409699,-0.032936078,-0.0028315978,0.017481707,-0.035851568,-0.014041506,-0.047626324,-0.008986536,-0.08520973,-0.018075002,0.03772878,0.024742339,-0.014312261,-0.033086825,-0.022285037,0.0817083,0.014606867,-0.048312407,-0.029339997,-0.004862589,-0.023470256,-0.022168497,-0.05385673,0.062455684,-0.046709675,-0.043416254,0.016862715,0.07138984,-0.046414632,-0.06235861,-0.0822101,0.054591835,-0.037463848,-5.0744225e-33,0.037943818,-0.075382106,0.045029145,0.0044377036,-0.06866656,0.054544706,0.0700516,0.05271599,-0.0014864738,-0.04053136,0.057348568,-0.009513567,0.05042932,-0.04696863,-0.0051838304,0.091441885,-0.104251936,0.0940172,-0.03479235,-0.03164753,-0.06032124,0.13438195,0.038841788,-0.0110931415,0.07518961,0.021130143,0.033264514,0.027311213,0.037718516,0.09896603,-0.0029967527,-0.055993773,-0.062817,-0.051777516,-0.0726636,0.039974764,-0.091911584,-0.079987064,0.0706792,0.009367814,0.019491853,-0.0021291487,0.06607648,0.02684379,0.042033482,0.094322,-0.06942515,0.0824247,0.0076908004,-0.013925349,0.034894112,0.016652634,-0.028521825,0.049856395,0.024438187,0.09881611,0.04361494,0.03705998,0.007634592,-0.02328814,-0.07538067,-0.008926303,0.048098497,-0.07035159,0.051927444,0.022530816,-0.056225214,-0.009638954,0.038690418,-0.077561356,-0.005780065,-0.040521983,0.012848,-0.02821858,0.016487338,0.06335201,-0.07799415,-0.014256095,-0.028224578,-0.008641239,-0.009418305,-0.0019996609,0.022450712,-0.084703624,0.06351041,0.0452151,0.04237955,0.09172062,0.03924718,0.096495055,0.0042579053,-0.04049823,-0.04095511,0.008292238,-0.0013174764,-4.60282e-08,0.0519523,-0.033830404,-0.0027918087,-0.044788174,-0.06911175,-0.024009654,0.0128620155,0.05521774,0.0073120287,-0.007735964,0.0059071556,0.08382491,-0.04966978,0.020603579,-0.05760043,0.03864086,-0.0030954457,0.0075837336,-0.016765125,-0.007879208,-0.142839,-0.068677366,-0.094836034,0.113476545,0.022306083,-0.06896284,0.029367756,0.0136082275,-0.119782284,-0.034967363,0.011828302,0.036357578,-0.07418349,-0.045397554,-0.032374933,0.0431201,-0.060954627,-0.010837659,0.034312792,0.036115587,0.016524894,0.004113646,-0.073290214,0.020017436,0.002180274,-0.017645331,0.034706723,0.087290674,-0.0679761,0.05858547,-0.025378084,-0.053945623,-0.06298944,-0.12454455,-0.024531625,-0.08326015,0.034750048,-0.043725953,0.028729199,-0.017598603,0.0043258914,-0.020692611,0.12645166,-0.027391769 +4.2.99.21,"This enzyme is part of the pathway of salicylate formation from chorismate, and forms an integral part of pathways that produce salicylate-derived siderophores, such as pyochelin and yersiniabactin.",384,1.0,-0.024716003,-0.08728804,-0.09494417,0.035949573,0.06630637,0.030740296,-0.0031796754,0.02442806,0.020734008,0.009106115,0.036708627,0.014759927,-0.039326258,0.04281479,-0.030203145,0.04793873,-0.115260765,0.043660335,0.0016217042,-0.034424663,0.0057405555,0.00021695584,0.04196241,0.028283564,-0.036891326,-0.047223613,0.09293693,0.054700874,-0.079343356,-0.04041028,-0.007362341,-0.009521503,0.041385774,-0.02768436,0.01590687,0.10224998,0.024260754,-0.043385852,0.041710045,0.007593844,0.028483182,-0.032667574,-0.0061060665,0.018326053,-0.013438895,-0.04707968,0.018435804,0.02798781,0.098826855,-0.04543927,-0.10568286,-0.008126599,-0.03838973,-0.02947084,-0.02637845,0.062362652,-0.08505678,-0.07765933,0.018294286,0.008740096,-0.04471218,-0.01977248,0.016369877,-0.08277048,-0.041349996,-0.114133626,0.03689572,-0.034591205,0.021262303,0.004283778,-0.033922266,-0.05218861,-0.08951112,0.015828276,0.044654597,0.021299578,0.007087407,0.0045395466,0.032680724,-0.070293926,0.027805774,0.02248447,0.020561691,0.12060505,0.06657446,0.00053725875,0.048409987,0.027428584,0.023000542,-0.0006933731,0.016466085,-0.0744222,-0.06329766,-0.05621394,-0.05883954,-0.059941437,-0.009640137,-0.021623492,0.004708673,-0.030803852,-0.03304031,-0.029925505,0.052812994,-0.08906387,0.012835437,0.03517899,-0.031776268,0.074614406,0.06172067,-0.01740844,-0.024116017,0.035290375,-0.009271964,-0.043481465,-0.006447466,0.09168284,-0.06939643,0.0054998416,-0.05841793,0.012064783,-0.005415769,0.012000588,-0.0073904097,0.09498865,-0.1091449,-0.02447554,-0.083426714,2.4768564e-33,0.0658488,0.019831806,0.02768436,-0.02583439,-0.07039809,-0.022951571,-0.03034748,-0.0017725134,-0.0027716488,-0.09691096,-0.0322742,-0.048564706,0.003007195,0.032762043,-0.008854002,-0.096011415,0.0017033955,0.008386677,0.047761172,0.0015704198,-0.0383264,0.100268126,-0.03341678,-0.046380207,0.047161855,-0.018244427,0.004459695,0.046801582,0.056296732,-0.008616939,0.06737129,-0.043497324,-0.027858293,0.012677112,0.067171104,0.03604069,-0.020724121,-0.030620316,0.036449924,0.088859096,-0.022481205,-0.007257316,0.017574314,-0.04662461,-0.023100317,-0.03987343,-0.029490774,0.088546865,0.08394919,0.02527639,0.0053217304,-0.012648843,0.11710815,0.023094626,-0.05376599,-0.017216237,-0.011888946,-0.042054955,0.030591952,-0.0035962225,0.036654845,-0.030852428,-0.0694816,-0.0020570187,-0.03944311,0.051611118,-0.021425648,-0.04756768,-0.017936217,0.05476275,-0.061005175,0.019614156,-0.0061435467,0.035559107,0.002996784,-0.041236095,-0.06342607,0.10301485,0.058755867,-0.013014409,-0.024283849,0.039028898,-0.016911926,0.055150256,-0.028877066,0.015503964,-0.029139131,-0.022984007,-0.061258566,0.024024671,-0.024671173,-0.054307505,-0.036719345,0.058393568,-0.009254311,-4.2376645e-33,0.039251313,-0.11392222,0.029958753,-0.052214712,-0.13816528,0.114356205,0.03288075,0.004185117,-0.045186687,-0.014281199,0.030013932,-0.045884285,-0.004978002,-0.085123256,-0.014115608,0.030123457,0.019800816,0.09825677,-0.04378958,0.013949634,-0.08577051,0.09587834,0.10572284,0.0146637345,0.02511372,-0.01083976,0.006633399,0.069542095,-0.014868193,0.07504133,-0.0132868225,-0.012548313,-0.07531177,-0.1073435,-0.100920714,0.0157079,-0.032065783,-0.006356453,0.014351865,0.004724231,0.05613156,0.008592246,0.05975042,0.11257407,0.0354881,0.09949694,-0.033443138,0.08126327,-0.04694048,-0.06400595,-0.013039558,0.021851195,0.06731106,-0.040667135,0.0073227524,0.061514232,0.007076825,-0.05203394,0.006696292,-0.107939444,-0.07602529,-0.014639768,0.022529133,0.0032910823,0.047282618,0.09494879,0.030341273,-0.05613936,0.05949755,-0.07804878,0.04918991,0.05760285,0.067004465,0.07234111,-0.01691309,0.033057623,-0.09845408,-0.06517858,-0.0059460877,0.024116386,0.024373919,-0.056149244,-0.025480166,-0.06175871,0.00077235466,-0.03302794,0.035337813,0.088969946,0.025551451,-0.010121919,0.031466655,0.0030664147,-0.038677398,0.10197591,0.08486895,-3.2378416e-08,0.064708054,-0.08849898,0.022744812,-0.06262268,-0.05034882,0.014403786,0.017178133,-0.005508244,0.02894326,-0.019510511,-0.07563543,0.12169188,0.021028297,-0.008587217,-0.050145492,0.112225756,0.04819083,0.019098025,0.011198845,-0.049967557,-0.07921434,-0.050457917,-0.029139522,0.07943026,0.054057356,-0.048527576,0.011126815,0.049087726,-0.029500676,-0.07086622,0.06444909,-0.047445305,-0.013030081,0.0048575224,-0.010769936,0.07764306,-0.06400587,-0.044663392,0.044275444,0.03378498,0.04310767,0.033625368,-0.02950016,0.014599145,0.042305287,0.052459866,-0.038031425,0.045144953,0.0035511623,-0.039490733,-0.031563032,0.005732441,0.038328417,-0.045127284,-0.12848279,0.065748215,0.020947043,-0.070145026,0.061656587,-0.03295563,-0.013383572,0.056961708,0.122281045,0.01653017 +6.3.2.28,"The enzyme from Bacillus sp. requires Mg2+ or Mn2+ for activity. While the enzyme has extremely broad substrate specificity, it does not accept highly charged amino acids, such as Lys, Arg, Glu and Asp, nor does it react with secondary amines such as Pro. The N-terminal residue of the -dipeptide formed seems to be limited to Ala, Gly, Ser, Thr and Met (with Ala and Ser being the most preferred), whereas the C-terminal residue seems to allow for a wider variety of amino acids (but with a preference for Met and Phe). However, not all combinations or dipeptides are formed. For example, while Ser is acceptable for the N-terminus and Thr for the C-terminus, a Ser-Thr dipeptide is not formed. D-Ala, D-Ser and D-Phe are not substrates. Belongs in the ATP-dependent carboxylate-amine/thiol ligase superfamily.",384,0.99999994,-0.012372947,-0.11607842,-0.0011988207,-0.07291257,0.017832095,0.025020761,-0.06347018,0.09473752,0.077566475,-0.009026119,0.052059505,-0.01031619,0.024817018,0.090017684,0.022282366,-0.034321476,-0.03131976,-0.03241088,0.043862775,0.025912918,0.08815172,0.058977652,-0.05770757,-0.028989512,-0.012259328,-0.061009366,0.10242048,-0.060821757,0.002045267,-0.06847151,-0.0804899,-0.011951184,-0.0054139346,-0.04441607,0.047727704,0.019023474,-0.04288053,0.049084894,0.07371251,0.0004330057,0.03550405,0.050013985,0.037949424,-0.08963431,-0.023772957,-0.02920516,0.07086563,-0.023683166,0.019167626,0.047513317,-0.020451332,-0.050694235,0.021807114,0.040724915,-0.017272858,-0.046013094,-0.11688344,-0.01985622,0.038386133,-0.022834348,-0.08987483,0.0018995091,0.026236115,-0.06701162,0.078366205,-0.05239954,0.015210012,-0.087295786,-0.019806864,-0.020502234,-0.10854799,-0.051386528,0.0026405943,0.05278235,0.027170438,0.017208224,-0.013408007,0.012155257,0.021887228,-0.03277752,0.061097864,0.062359717,0.00203046,0.10638762,0.044176895,0.016979204,0.0005593196,0.06978698,0.06071351,0.00030982072,0.06439791,-0.0132180285,-0.014845498,-0.069430225,-0.08735209,-0.011979715,-0.043591034,0.05281669,-0.025894482,-0.015463488,0.0081143305,0.085247286,-0.045435198,-0.022042833,-0.013414798,0.004272953,0.021679018,0.042146396,0.075640716,-0.00054077926,0.060130678,0.038293496,0.031786915,-0.074382015,-0.029861089,0.009653437,-0.046677098,-0.09268613,-0.015892072,-0.09010817,0.01843798,-0.0045708134,0.036736883,0.056559686,-0.015070863,0.060034424,-0.067317285,1.949948e-33,0.07616263,-0.01767845,0.1006719,-0.031012762,-0.01692267,-0.06934895,-0.047736224,0.011499312,0.0031399329,-0.054287832,-0.14173453,-0.08796759,0.03089433,0.022358008,0.06406438,-0.0006501304,0.029185217,0.037166815,0.0680759,0.0021517558,-0.014601526,0.008768869,0.045003507,0.038118895,0.078537315,0.0154775325,0.025552094,0.042467605,0.020669118,-0.01105251,0.0046765264,-0.095908515,-0.04688598,0.034728464,0.05848629,-0.031989694,-0.05852695,-0.01998415,0.010041342,0.05228214,-0.024398332,0.06651405,0.004199395,0.03806315,0.04367809,-0.05487424,-0.012075497,0.04781709,-0.019192148,0.07353072,0.08391508,-0.0103856055,0.09146788,-0.0056953877,-0.032322343,0.042577345,-0.035412114,0.034026578,0.031380143,0.10535956,7.949799e-05,-0.001970005,-0.0525481,0.0564648,-0.016466942,0.12084537,-0.12968224,-0.016372273,0.051445574,0.05362212,-0.018261103,0.006599067,0.07860828,0.040508945,-0.023826078,-0.031413067,-0.05648049,0.010523543,0.03345161,0.029122738,0.014340937,0.026019339,-0.07610435,-0.015689641,-0.06812244,-0.039344992,0.06191695,-0.09126269,-0.040010046,-0.00051875337,-0.019456515,-0.020763116,-0.043353844,0.037845813,0.015874483,-3.288085e-33,0.09128468,-0.11498984,0.069360495,-0.11707216,-0.10361703,0.019226642,0.06665573,-0.08108349,0.02025489,-0.09433643,-0.0014502459,0.036754705,0.0005841476,0.015296202,0.0015402999,0.0074440106,-0.100326866,0.10423658,0.040305562,-0.047613382,0.03714729,0.066418536,0.014004114,-0.008624146,0.049889572,0.008376298,-0.00576697,0.12360091,0.038145557,0.047096856,0.0059572123,0.065486796,-0.017575454,-0.052405626,-0.06426636,0.07413962,-0.04491372,-0.03615283,0.047334373,0.015914556,-0.021787083,0.032552794,0.0531355,0.044131093,0.026401054,0.060120445,-0.033752553,-0.0341846,0.04424376,-0.11276192,-0.019035928,-0.03306161,0.035910126,-0.06702374,0.026212785,0.007086375,-0.01888712,0.036365896,0.03656201,-0.07024295,-0.01315514,-0.031921748,0.029079437,-0.04237543,0.0038074313,0.03701049,-0.0022668447,-0.05988925,0.02434059,-0.056736466,-0.015235086,-0.0429161,0.05809155,0.012478275,-0.03412251,0.034950197,-0.06640083,0.006702855,0.02810598,0.013544402,-0.084254846,0.010248732,-0.07602466,-0.029860478,0.012904378,0.0047012847,-0.0049844394,0.028136477,0.013013011,0.021925228,-0.06224328,-0.013444118,0.063765235,0.048541456,0.03200577,-5.6541055e-08,0.13095224,-0.026823534,-0.018790942,-0.01989548,-0.004766447,0.016625276,-0.06514023,-0.09686726,0.0056692795,-0.031507194,0.024757147,0.016089665,-0.098789714,0.015812563,0.072283626,0.022867894,-0.0686382,-0.00013156999,-0.06313016,-0.0033427416,-0.08096254,-0.010234721,-0.11703903,0.050751347,0.018229002,-0.04848079,0.0271776,0.030592974,-0.053830393,-0.017552251,-0.009691393,-0.030869592,0.00920975,-0.051253576,0.02082155,-0.0055470336,-0.10665863,0.01366674,0.033256978,0.07274287,0.046762384,-0.09787408,-0.054895576,-0.012828169,0.015338096,0.07025331,-0.02717738,0.10065626,-0.06728695,0.011300575,-0.031655155,-0.05855339,-0.024298772,-0.009351558,-0.055136893,0.020152954,-0.00569737,-0.0685016,0.013942176,-0.049592454,0.05075078,0.06457333,0.09476066,-0.013163286 +4.1.2.8,"Forms part of the defence mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyses the first committed step in the formation of the cyclic hydroxamic acids 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) [1]. This enzyme resembles the alpha-subunit of EC 4.2.1.20, tryptophan synthase [3], for which, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate is also a substrate, but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released [2].",384,1.0,-0.04980937,-0.030655423,-0.078379385,-0.048367664,0.04829637,0.12084328,-0.054750487,0.014781446,0.08848596,0.09364501,0.07032065,-0.04826088,-0.058036726,0.07786139,-0.08386992,0.06451151,0.0073691946,-0.008678768,-0.04589845,-0.039564874,0.008533959,0.0810313,0.036683325,-0.0043510664,-0.06055141,0.015795285,0.00035422452,-0.016250487,-0.0228381,-0.055089477,0.05295414,-0.038265213,0.034579117,-0.013202373,0.014170027,0.042011354,-0.06222431,-0.07917941,0.13221611,0.03440091,-0.023855846,-0.021493517,-0.065919064,-0.039535444,-0.082728334,-0.010682545,0.057488006,0.06024469,0.10735221,-0.10796631,-0.028178602,-0.07106236,0.005107023,0.0565385,0.0075465664,-0.019579247,-0.0322429,0.08182034,-0.04575342,0.04020769,0.011799007,0.034249738,0.004340967,0.020372018,-0.031843614,-0.07514164,-0.03174732,-0.041849557,0.02722337,-0.018016953,-0.065883055,-0.04594198,-0.07754397,0.0030107175,-0.046663485,0.078202896,-0.02426218,0.038869645,0.023283878,-0.102642015,0.03637285,0.00091862073,0.09077382,0.106948934,0.0029008402,-0.04284526,-0.03684136,0.09564045,0.08603505,-0.021047063,0.056065004,-0.04555675,0.009381836,0.04467833,-0.007997559,0.05613185,0.0024868017,-0.0436776,0.045906305,0.02616017,0.012750873,-0.0149081815,-0.032766256,-0.09425582,-0.06958446,0.022283124,0.032290246,0.05209278,0.069619276,-0.018275978,-0.038511973,0.012390711,0.0388055,0.06395689,-0.09847575,-0.005148705,0.005154837,-0.06248765,-0.0033318587,0.009685767,0.071553126,-0.026833188,0.08880636,0.073196195,-0.021676855,0.05271706,-0.12854557,7.0644276e-34,0.122387365,0.038280614,-0.038805954,-0.020844392,-0.032941256,-0.015470113,-0.059413496,0.028172877,-0.019389436,-0.03127997,-0.034315154,-0.09669284,0.11104541,-0.024747476,-0.0072282036,0.062084775,-0.09486153,-0.033537805,0.032707654,0.0053135036,-0.07013693,-0.034798317,-0.013634055,-0.049359635,0.05470181,0.06741176,-0.009463389,-0.02536175,0.03265251,-0.0080934195,0.054245517,-0.07443476,-0.15105036,0.069447204,0.05446266,-0.00060513284,-0.058954228,-0.05025299,-0.02185641,0.015592765,-0.017124077,-0.014713533,0.016004756,-0.038563732,0.12751938,-0.005125766,-0.07621265,0.09910306,0.046863213,0.04195323,0.08810301,-0.017577674,0.121574685,0.016882937,-0.037202563,-0.008245409,0.032251522,0.016856615,0.010917245,0.015586343,-0.077506974,0.052537628,-0.06310325,-0.023178564,-0.015996618,-0.054783516,-0.057902217,-0.028688762,-0.041835938,0.026888223,0.024157235,-0.027730035,0.035999447,0.04327674,-0.03991099,-0.054367006,0.014795954,0.033240207,0.012778583,0.039660282,0.032934092,-0.02096917,0.04539812,-0.036245715,-0.07868315,-0.0038568093,0.009584849,-0.05474704,-0.003371267,0.009936338,0.03415617,-0.040544774,-0.042264044,0.048845906,0.017519705,-2.1394339e-33,0.03531027,0.0054115723,-0.004387531,-0.088138476,-0.021831846,0.044030346,-0.003287927,0.012827098,0.015593316,-0.027410103,0.02259489,0.006734166,0.07067577,0.00526782,0.07530118,-0.05629647,-0.059108958,0.08902147,0.0019317465,-0.062077634,0.009314984,0.051487908,-0.015461754,-0.0008369326,0.023001088,-0.012148777,0.0040370156,0.14528501,-0.0028365909,0.09026908,0.069335625,-0.018373668,-0.057644557,-0.030415522,0.056359153,0.039369695,-0.073087044,-0.061997976,0.022785123,0.012987484,-0.0069969683,0.024381503,0.09393022,-0.019444512,0.023584908,0.13761796,-0.056108296,0.014549874,-0.03821751,-0.026338676,-0.022344189,-0.0063347085,-0.014793625,0.034290608,0.07369594,0.051734515,-0.003854831,0.020308388,-0.0071867253,-0.07576057,-0.043927215,-0.018316058,0.058467235,0.033702075,-0.017078305,0.05718808,-0.013807776,0.1088339,0.05334716,0.033987306,0.019363755,-0.025402026,0.03065148,0.030323314,-0.07777287,0.008244362,-0.026218953,-0.05470795,-0.017745154,-0.016526619,0.06992973,0.035468213,-0.005556739,-0.05250934,0.04011043,0.00020472945,0.00931407,0.115925446,-0.0036406324,0.0055895923,0.031615745,0.005323379,0.00896049,0.09935647,0.074559286,-5.1396707e-08,0.054013196,-0.081758276,0.028484277,-0.07672952,0.011166507,-0.02495905,0.026692422,0.008230324,0.018990757,-0.052584417,0.012070955,-0.011380925,0.014071614,0.05180511,0.004323052,-0.019362813,-0.064780384,-0.015293689,-0.038932912,-0.024645217,-0.06165926,-0.030116208,-0.06466688,0.030018127,-0.008596996,-0.090209976,-0.007961674,0.003027069,-0.021054655,-0.04553878,-0.016742568,0.102898866,0.01961255,-0.0104505755,-0.12981078,0.013304483,-0.016806563,0.012425623,-0.004092575,-0.01359305,-0.009260829,-0.045998696,-0.034796607,-0.022904592,0.033544414,-0.078476116,0.0052497657,0.0128532825,-0.014772322,-0.0647109,0.0011149003,0.052194715,0.010854143,-0.0303743,-0.102712415,-0.04435868,-0.068725795,-0.026531179,0.015592468,-0.067907885,-0.037440497,-0.015400683,0.103209,0.011064647 +1.14.11.28,"Requires iron(II) for activity. Unlike the proline hydroxylases involved in collagen biosynthesis [EC 1.14.11.2 (procollagen-proline dioxygenase) and EC 1.14.11.7 (procollagen-proline 3-dioxygenase)], this enzyme does not require ascorbate for activity although it does increase the activity of the enzyme [2]. The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not substrates [2].",384,1.0,-0.06370797,-0.11634346,-0.064416684,0.018499536,0.057761695,0.01741786,-0.047390517,0.090397954,-0.029221328,-0.022429086,0.02489696,0.053845335,-0.071690254,0.031597782,-0.054857947,0.029320905,0.012074781,-0.105749846,-0.02590503,-0.008919953,0.065733485,-0.037723042,0.026109396,-0.011960459,0.050147563,-0.10770881,0.028365223,-0.0025056829,-0.02177532,-0.035436586,0.034607776,-0.08456711,0.0495717,-0.013139084,0.07692408,0.008628602,-0.054564845,-0.044082962,0.0037978129,0.06759603,0.042307213,-0.06002988,-0.06719039,-0.01261634,0.049929775,-0.080773115,0.00973874,-0.03168703,0.0036145393,0.086551644,-0.05331363,0.024822637,-0.020202879,0.017523918,-0.106673,0.040200427,-0.04436766,-0.023631863,-0.06867711,0.038677245,-0.03651007,-0.015181223,-0.03262372,-0.05356743,-0.0010466198,0.011235653,-0.035789765,0.030119056,0.0050037852,-0.008888134,-0.017384093,-0.032340687,0.04078187,0.050472707,0.02656578,-0.02133817,-0.014496783,-0.042554695,0.002242859,-0.08759954,0.024062667,0.026556425,-0.0010614287,0.04621891,0.009235103,0.0064245174,-0.02465629,-0.017104855,0.0035051217,0.07802458,0.013045242,0.016606791,-0.04039838,0.042840965,-0.040869255,0.037536837,0.05541544,0.019728748,-0.016541129,-0.03216208,-0.041328784,0.023752699,-0.0065430743,-0.055898458,-0.03516921,0.013469518,-0.023627874,0.08801489,0.064506546,-0.028246066,0.08072661,-0.035694413,-0.020025283,0.028768592,0.012594414,0.091004014,0.0205855,-0.10476949,0.00716985,-0.049096815,0.06020858,-0.0042699883,0.10876699,0.054560684,-0.09934976,0.06607111,0.028599814,5.167103e-34,0.043786388,0.027083373,-0.0067507937,0.0052422136,-0.05411512,0.028393978,-0.14019084,0.004273233,-0.02838292,-0.09863594,-0.05937381,-0.07149379,0.06265333,0.005697226,0.043050606,-0.07644174,0.051984344,-0.043662567,0.0978491,0.055977773,0.0749501,0.04062915,-0.043285124,0.046586458,-0.03342255,-0.005530992,0.015924713,0.08237535,0.00033016113,-0.013763876,0.04760717,-0.11850052,0.02220172,-0.013824919,0.05880617,0.017447075,-0.034961294,-0.04101523,-0.0106402105,0.010343408,0.019658934,0.042234726,0.016958198,-0.06711722,0.06961602,-0.092740454,-0.0051908363,0.1173075,-0.04035014,0.06941922,0.07001184,0.08646783,0.10805399,-0.004547704,0.010640091,0.036116175,-0.08776021,0.026629083,0.10366218,0.055233292,0.06801538,-0.014936622,-0.026803065,0.030344991,0.006687475,0.062480234,-0.066586114,0.07345116,-0.045862123,0.047993533,-0.06961966,0.0019900035,0.054566476,-0.026049118,0.027301066,0.014324172,-0.08152558,0.09317672,-0.017588101,-0.039833046,-0.010842067,0.07446859,-0.055299968,0.024791703,-0.023669228,0.038434047,0.04061615,-0.0058722715,0.05822329,-0.020565176,0.041162387,-0.04488594,-0.06169063,0.020717677,0.046464883,-2.2015365e-33,0.041127082,-0.063442826,0.03812184,-0.034981564,-0.037984747,0.06569446,0.11448021,-0.07431699,0.032188084,0.058979686,0.07888186,-0.012218529,-0.058290485,-0.09879383,0.05976622,0.061209466,-0.12031996,0.058739554,0.014907184,0.02214548,0.045764025,0.12624313,0.037202127,0.07870616,0.044597987,-0.030468114,-0.010736708,0.025766619,0.032776207,0.05621125,0.0550024,0.04208788,-0.025580635,-0.08859717,-0.05275854,0.0599816,-0.06476806,0.040784772,-0.020434424,-0.030029435,0.0036603978,-0.023072612,0.019375905,0.033462867,-0.010376769,0.037395712,-0.11932399,0.0005925799,0.011011059,0.023039104,-0.015410325,-0.04274319,-0.016544366,-0.03284817,0.033688106,0.034783114,0.032640293,0.04913094,-0.03335527,-0.018978843,-0.024079988,-0.048120607,0.03570092,-0.045968823,0.05306459,-0.040584605,-0.04292765,0.023094043,0.035490476,-0.008137262,0.06925907,0.045634616,-0.033171687,-0.016792051,-0.037673138,0.007058356,-8.708135e-05,0.014994878,-0.08303539,0.017465085,-0.03635088,-0.028392727,0.020397652,-0.076294675,-0.05714412,-0.016455531,0.0110033285,0.08674122,-0.0056014988,0.03525738,0.009241044,-0.09183549,-0.047000203,0.02080322,0.027081348,-4.3166686e-08,-0.035218958,0.0045207427,0.08522236,-0.08152657,-0.013059284,-0.04729873,0.051999263,-0.04813976,0.039991893,-0.061335966,-0.007630105,0.07651682,-0.028137816,-0.017231476,0.01035503,-0.0036468275,-0.0013811643,0.058997817,-0.02454448,-0.0019393724,-0.043227404,-0.07376097,-0.11286546,0.07276354,-0.010627962,-0.0665167,0.002860485,0.026426567,0.013175336,-0.043011844,0.028607462,0.00082522456,0.08428592,-0.067257196,-0.038912553,0.008503523,0.0026070129,0.021382216,-0.06418865,0.07602742,-0.03091213,-0.10356968,0.047503654,0.0034028217,-0.012486067,-0.016863495,-0.0049686907,0.037028115,0.0022423617,0.05828993,-0.052942682,-0.06740422,-0.06068272,-0.06752389,-0.05640804,0.06990049,-0.026961539,-0.06627411,-0.03311042,-0.05312902,0.064664796,0.007057919,0.15267299,-0.07233569 +1.17.99.5,"Under physiological conditions, the reactions occur in the reverse direction to that shown above. This enzyme is highly specific for bile-acid substrates and requires a free C-24 carboxy group and an unhindered 7alpha-hydroxy group on the B-ring of the steroid nucleus for activity, as found in cholate and chenodeoxycholate. The reaction is stimulated by the presence of NAD+ but is inhibited by excess NADH. This unusual regulation by the NAD+/NADH ratio is most likely the result of the intermediates being linked at C-24 by an anhydride bond to the 5'-diphosphate of 3'-phospho-ADP [2,5,6]. Allo-deoxycholate is also formed as a side-product of the 7alpha-dehydroxylation of cholate [6]. The enzyme is present in intestinal anaerobic bacteria [6], even though its products are important in mammalian physiology.",384,1.0,-0.011038049,-0.08786794,-0.061413735,0.0045281127,0.0041009374,0.07838344,-0.07114701,0.02737741,-0.0044944966,0.076158874,0.014508698,-0.019777553,-0.06886908,0.029715957,-0.055950284,0.060772147,-0.057383306,-0.020892546,0.0215661,-0.0022065362,0.00879183,-0.024811963,0.02581462,0.01635101,0.058386702,0.01172206,0.07684389,-0.021219667,-0.05776417,-0.077983074,-0.04329549,-0.024021128,0.10465855,-0.0306437,-0.033869654,0.048415508,-0.07589398,0.02136862,0.032138713,0.0422478,-0.0166231,0.011772409,-0.08728981,0.0025700533,-0.027986454,-0.05189256,0.011634724,0.048835468,0.06350057,0.035224635,-0.023042312,0.0041988343,0.007373475,0.012040482,0.029040238,0.04240996,-0.026899874,-0.03296095,-0.017634751,-0.06915975,-0.020854298,-0.07629439,0.019607248,-0.029326843,0.02518215,-0.05098094,0.0946155,-0.04023507,-0.016623976,-0.08839609,-0.05182519,-0.0458293,0.0031207167,-0.0046479017,-0.023589462,0.07760021,-0.07387825,-0.047076363,0.03605014,-0.014613007,0.018482763,-0.041304257,0.012184621,0.094905935,0.087359756,-0.043735314,-0.00960887,0.054367173,0.019384403,0.026629606,-0.036317214,-0.019164767,-0.060797647,-0.028176429,-0.06982606,-0.02294337,0.06967756,0.030907938,0.029800164,-0.048343614,0.0628048,0.119812235,-0.021065488,-0.087736845,0.024698678,0.055466164,0.017881049,0.06786345,-0.023795618,0.0069169346,0.0004531735,0.0021995658,0.039343894,-0.05621443,-0.04830549,0.1300817,7.535965e-05,-0.042268097,-0.10089902,0.02232967,-0.021197122,0.032697294,-0.008794267,0.071718566,-0.019514948,0.014424849,-0.07720888,2.5692747e-33,0.06157219,0.034850426,-0.025940469,0.022664573,0.035291627,0.052376874,-0.06545524,0.028131787,-0.0070690666,-0.0021618968,-0.002560567,-0.034266755,0.094136074,-0.0041765664,-0.06008321,0.02363761,0.0141056655,-0.048522647,0.052322008,-0.013153583,-0.029411199,0.058622435,-0.09320755,-0.013321674,-0.009427265,0.021940274,-0.030445052,0.08286547,-0.009745339,0.006874071,-0.013470554,-0.0838202,-0.027697654,-0.011486929,0.09535153,-0.027347729,-0.10269704,0.025473814,-0.022532228,0.091939285,0.0035750708,-0.0222504,-0.046687156,-0.04594989,0.04463273,-0.084454305,0.000765427,0.06117454,0.06509092,0.06470491,0.055482335,-0.06458198,0.0880868,-0.046216108,-0.03565834,-0.007064943,0.0065930733,-0.033421155,-0.015442585,0.098048724,0.047009945,0.030215152,-0.09903258,0.07646904,-0.06416575,-0.004506822,-0.10490932,-0.08694363,-0.07224122,0.0068032877,-0.038978294,-0.004439976,0.06071533,0.03335604,-0.06728175,0.009699395,-0.035683174,0.034245666,0.006849386,-0.04887779,-0.014148395,0.005016182,-0.03291063,-0.0053566615,-0.03019452,0.05659729,-0.03004455,-0.06930887,-0.038581472,0.048915315,0.041867845,-0.06667251,-0.06913382,0.0020857295,0.08071366,-5.3551096e-33,0.07487913,-0.07989775,0.03316011,-0.1358602,-0.020665081,0.1894423,0.059360113,-0.04939384,0.053185128,-0.075720035,0.04149065,0.011567715,0.01373213,-0.024070194,0.045071814,0.041578643,0.031503364,0.11016926,-0.010990239,-0.06782558,0.024855694,0.12858464,0.011185097,0.058277003,0.062363263,-0.019461317,-0.014469953,0.02448684,0.06459124,0.1730157,-0.028295401,-0.021849606,-0.038918417,0.0022135954,0.026075669,0.05168821,-0.1199746,-0.018290328,-0.01348777,0.042386986,-0.07580346,-0.037748642,0.042149793,0.012518877,0.053981856,0.036909476,-0.06054798,-0.032374702,0.00022937146,-0.02042666,0.057798386,-0.024063326,0.0021350153,0.0062186494,0.04339486,0.07253909,-0.06355932,-0.019361818,0.06186724,-0.08716587,-0.0017234134,0.009143338,0.018489469,-0.025633493,-0.042548846,0.04509277,-0.060957856,-0.00478716,0.03651689,-0.080555804,-0.0017920542,0.063205704,-0.04024643,0.07414906,-0.015924767,0.026203983,-0.08316411,0.0065397094,0.0038466821,-0.0041377805,-0.06155003,0.016140535,0.02367931,-0.025714587,-0.03152114,-0.06042352,-0.025735287,0.027795633,0.006354724,0.0142294215,0.027647763,-0.004952021,-0.12421994,0.02503278,0.033101454,-5.466863e-08,0.046031743,-0.049696896,-0.007018458,-0.0141672995,0.016745709,-0.016962914,0.04801295,-0.064605616,0.025720175,-0.026802668,0.019710727,0.15219514,0.040357333,0.045044336,0.021068644,0.035909567,-0.0674797,0.011268057,-0.026865589,-0.024747234,-0.08173991,-0.0544973,-0.036414117,0.05016379,0.021295516,-0.038639143,-0.0018159203,0.03165904,0.012471965,-0.061618224,0.11820082,-0.062211744,-0.050687946,-0.052273627,-0.028824294,0.041086502,-0.022456795,-0.0075456006,0.0007860506,0.071576364,-0.012094286,-0.052927714,-0.04942877,0.061802022,0.02723161,0.01782404,-0.031016963,0.033810712,-0.033160724,0.0013432961,-0.03127216,-0.005618805,0.0028824175,-0.0106173,-0.035361607,0.010987231,0.014911829,-0.10316888,-0.010990041,-0.030620651,0.012975211,0.055828165,0.12443313,-0.055309135 +3.4.14.12,"This cell-surface-associated serine exopeptidase is found in the Gram-negative, anaerobic bacterium Porphyromonas gingivalis, which has been implicated in adult periodontal disease [1]. The enzyme releases the N-terminal tripeptide of peptides, such as interleukin-6. It has an absolute requirement for a proline residue at the P1 position but is completely inactivated by a proline residue at the P1' position [1]. The size of the peptide does not affect the rate of reaction [1].",384,1.0,-0.057361223,-0.08026606,-0.115986235,-0.036587093,-0.002470364,0.052979708,0.03733571,0.13341254,0.11412623,0.0806783,0.040267073,0.045400187,-0.08980695,0.0962136,-0.032990772,0.041162733,-0.08685661,0.022584066,0.04866732,0.052822348,0.124274485,0.053123225,0.029634826,-0.095029026,-0.0109394,-0.030939002,-0.028850282,-0.05972119,-0.026421452,0.0676461,-0.013933751,0.011306961,0.029980592,-0.0818908,0.1221199,0.020540943,-0.004151871,0.023626398,0.07578406,0.007020219,0.030175673,0.065433316,-0.043627407,-0.08159718,0.054304812,0.052891016,-0.014767504,0.08136657,0.036373198,0.020544205,0.06771339,-0.07647864,0.029892925,-0.049438063,-0.015386636,-0.0048827766,-0.052780204,-0.05986975,0.030802933,0.06270532,0.048328497,0.0037480348,0.034187943,-0.011446105,0.017800638,-0.09488604,0.043799665,-0.007816273,-0.015651837,-0.039435696,-0.049773376,-0.05823268,-0.021058839,-0.016808603,-0.0054693837,0.07604951,-0.049695,-0.027394807,-0.051055603,-0.019393904,0.06380878,0.02464849,0.061137713,0.14685524,0.05839255,-0.06276172,0.0358078,0.048898347,0.035210922,0.014794741,0.0028852667,-0.031995576,-0.0076060425,0.013201748,-0.011486801,-0.019545946,-0.035824355,0.07776183,-0.051647726,0.020062625,-0.09114665,0.031060532,-0.009127058,-0.07595231,-0.02122859,0.017692545,-0.00038496853,0.072261296,0.042092867,-0.03947777,0.010896139,-0.00026838496,0.01765018,-0.009147751,0.07607657,-0.02699591,-0.030748382,-0.032367863,-0.013509875,0.025345245,-0.0009387418,-0.006581102,0.022950444,0.05582338,-0.032354817,0.05921133,0.03990867,2.9059974e-35,0.034334056,-0.0022410445,0.103163026,-0.08252395,0.041366473,0.07099307,-0.011239748,-0.066639245,0.030914899,0.0031390355,-0.06711367,-0.08584373,0.05868465,-0.029901901,-0.003970874,0.013666672,-0.047909826,0.029859321,0.0556331,0.008939452,0.03972994,0.022126632,0.027933268,-0.01103249,-0.013993268,0.019595608,-0.05485251,-0.039752495,0.049684495,-0.015687866,0.033161607,-0.07453492,-0.03436446,-0.03297414,0.060047735,-0.007921311,0.03953907,-0.03989618,-0.075126745,-0.06043249,-0.06959559,0.020685904,-0.06269165,-0.012735432,0.019640341,-0.13165534,-0.07381373,0.093148164,-0.0034194773,0.083098665,0.021905657,0.0049734977,0.023546765,0.01049696,-0.08198544,-0.01397268,0.010020124,0.016129585,0.00085924944,0.04408961,-0.009013739,-0.036334064,-0.047782887,-0.0053921985,0.0048940117,0.048243042,-0.017097313,0.00020793623,-0.009168065,0.073175885,-0.07624498,-0.023106022,0.025675159,0.062178623,-0.042944096,-0.03234443,-0.002456784,0.11029494,-0.031659346,0.009274041,-0.004526636,-0.023923434,-0.09192134,0.029773062,-0.014107248,0.006979517,0.01449621,-0.04252769,0.026546724,0.017597789,0.09368142,-0.024574801,-0.100746855,0.061385017,-0.06637876,-1.5783974e-33,0.048696265,-0.051566,0.004550308,-0.103048325,-0.029576862,0.13409303,-0.0033860693,0.03583426,-0.04347258,-0.00838123,0.05779152,-0.0023028278,0.030875528,0.04449679,-0.03054942,0.008426717,-0.054973796,0.0778175,-0.016794987,-0.022612713,0.05282153,0.023869501,-0.0052512623,0.024806218,0.07332357,0.028702604,-0.040818177,0.042354174,-0.039377816,0.06500104,0.04317212,0.07757196,-0.027574787,-0.06377981,-0.025610777,0.06323071,-0.038295753,-0.054513626,0.03349922,-0.02429399,-0.01350411,0.014083605,0.047646347,0.06916319,0.07312848,0.1101469,-0.05077884,0.04234944,-0.027437316,-0.0014649472,-0.02593318,-0.019755816,-0.020843042,-0.049900543,0.02674091,-0.033392437,-0.019865187,-0.046548944,-0.109380655,0.042231943,0.060630057,-0.012727932,-0.01332215,0.011933728,0.06119092,-0.032964595,0.049407054,0.041495558,0.06863014,-0.07701705,0.02442097,0.01775089,-0.011020084,0.025674788,-0.006018102,-0.012784064,-0.042123,-0.012506066,0.03356377,-0.025342802,-0.071827985,0.039712045,-0.011231244,-0.043858957,0.03858808,-0.05638738,0.022056986,0.080256894,0.0048839366,0.06533838,-0.077374235,0.014075446,-0.050079245,0.023468817,0.06092102,-4.3250587e-08,0.09962017,-0.02516545,0.07718987,-0.07493865,-0.062103685,-0.03393545,-0.085323684,-0.00083792466,-0.014233923,-0.08783713,0.07618802,0.028848566,-0.018909844,-0.03149529,0.020329274,0.017767513,-0.008546775,-0.035368714,-0.046588007,-0.074038014,-0.042624764,-0.037902404,-0.048051182,0.015331634,-0.0062856437,-0.07190109,-0.012184946,0.108212166,-0.034863453,-0.03959162,0.053407952,0.008729342,-0.05523041,-0.03980248,-0.074657165,0.03906914,-0.07048013,-0.03379516,-0.042779908,0.005398003,-0.09506793,-0.044169728,-0.068432175,-0.03046587,-0.0030802153,0.07147887,0.050132535,0.057354692,-0.07147538,-0.0056212577,-0.02903651,0.0072339424,-0.028328381,0.0122021455,-0.1345495,0.08210121,-0.008133026,-0.044742532,0.032823335,-0.06885305,-0.053628713,-0.02139933,0.1289946,-0.021298248 +3.4.21.106,"This type-II membrane-associated serine peptidase has been implicated in cell growth and development [1,3]. The enzyme has been shown to activate blood coagulation factor VII by cleavage of the Arg152!Ile153 peptide bound in BHK cells, thus indicating a possible role in the initiation of blood coagulation [2]. There is no cleavage after aromatic or aliphatic residues [1]. The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphatic residue. The nature of the residue at S3 also affects hydrolysis, with Gln being much more favourable than Ala [1]. Belongs in peptidase family S1A.",384,1.0,-0.08958448,-0.055431116,-0.1285497,-0.08995597,0.113629796,0.015459734,-0.02485647,0.07073664,0.06981169,0.0046301484,0.014107377,0.0015673942,-0.055952433,0.08470546,-0.017444246,-0.024012592,-0.037636343,-0.041111164,0.00045260528,-0.0891816,0.04176572,0.006482431,-0.005532296,0.0268454,-0.0021044102,0.018266138,0.041749537,-0.06552117,0.031977415,-0.040688615,0.029897543,-0.05285919,0.033347987,-0.081028886,0.041485317,-0.031266287,0.033925787,-0.040959857,-0.034734793,-0.023445683,0.100902736,-0.027762245,-0.070089415,-0.11823822,0.036825407,-0.05205376,0.03303564,0.03485029,0.034405254,-0.02320567,0.0071614813,-0.06847996,-0.042513043,0.02728466,-0.017816361,0.004107138,-0.095779516,-0.026624141,0.03487822,-0.0023095212,-0.034931928,0.05551977,0.033453166,-0.0486057,0.026686342,-0.11347179,0.04577692,-0.033136997,-0.0057232613,0.021776022,-0.02396244,-0.05801962,-0.08481308,0.063397154,-0.011484839,0.073778905,-0.027788255,-0.051728427,-0.04035254,0.016465567,-0.007083947,-0.0006400832,0.09153901,0.15414928,-0.03104192,0.032998487,-0.018263562,-0.002799493,0.016513767,0.03124734,0.07279911,-0.08080447,0.061864693,0.09245533,-0.017325692,0.0491555,-0.0073755747,-0.047698945,0.020994402,-0.0025560884,-0.03333792,0.06773259,-0.02762226,-0.017397083,-0.004392824,0.066871434,-0.050027344,0.105156854,0.058638696,-0.020330204,0.06717919,-0.029104697,0.07657159,-0.063892394,0.030239487,0.09465649,0.0016448548,-0.00024158409,-0.035513483,0.016528632,0.061648693,0.05430808,-0.015433766,0.055351965,-0.0003916958,0.047190223,-0.08393997,4.443819e-33,0.046819482,-0.04892488,0.081325166,0.07797385,-0.059432942,-0.04505177,-0.057837322,-0.020724934,0.026361998,-0.023172498,-0.08318746,-0.08726693,-0.019973742,-0.023570906,-0.055119164,-0.017301079,0.004465969,-0.058420982,0.03949252,0.044160742,-0.011936346,-0.018651037,0.015745424,-0.07852628,0.085218206,-0.009627526,0.025608517,0.038816728,0.05687933,0.026398689,-0.043235555,-0.0794257,-0.06606075,-0.0035253128,-0.019311277,-0.030813167,0.052005418,-0.053767446,-0.01857292,0.048914876,0.04751195,0.035997186,-0.06374671,-0.04398937,0.07119698,-0.045035753,-0.034565788,0.09433519,0.02138692,0.02109082,-0.0032942165,0.0015116091,0.13630782,0.047454756,-0.031411886,0.009261272,0.0022338727,-0.04634788,0.052039117,0.03239824,0.03286647,0.0217384,-0.038196407,0.09267994,-0.0044154464,0.04661203,-0.051590487,-0.0015246485,-0.0016809481,0.08040119,-0.07574067,0.070919104,0.08885273,0.0453826,0.049362097,-0.13072096,-0.009331695,0.09643632,0.05376623,0.07946369,0.015590444,0.0322873,0.007791506,0.025107488,-0.056502707,-0.03793809,0.043158412,-0.08522875,-0.07555942,-0.0055619413,0.034505375,-0.045644168,0.009649518,0.057773042,-0.055279344,-5.4278323e-33,0.11502959,-0.12607318,0.004586421,-0.12614097,-0.051362447,0.05586055,0.060518265,0.023163106,0.028973158,-0.014104418,0.024528775,0.061255064,-0.04516937,-0.044675853,0.04920107,-0.02875712,-0.044330183,0.037793126,-0.015269431,-0.011357536,-0.067865305,0.010600892,0.07549206,0.031169785,0.049714025,-0.017160863,-0.042759582,0.05130073,-0.06093677,0.011798005,0.018805593,0.03372952,-0.07343824,-0.046970073,-0.08368926,0.035903376,-0.023402216,-0.0060403934,0.017401002,-0.058867943,-0.021530012,0.04029731,0.08553319,0.030172266,0.010195829,0.0798926,-0.019954829,0.05766338,0.004459086,-0.14424637,-0.032545257,-0.026372993,0.026970744,0.090220414,0.06344613,-0.011264668,0.054989945,0.041898772,0.0048012026,0.03238996,0.03588411,0.01866161,-0.03591512,-4.8090766e-05,0.05438253,0.002727725,-0.050762694,0.011701934,0.10269827,0.014970878,0.008088775,-0.04369658,0.036366243,0.00088670565,-0.0012755654,0.012268486,-0.09056303,-0.0053009186,-0.015046553,-0.07190533,-0.057736665,0.008356213,-0.069905624,-0.042271663,0.001995754,-0.055849295,-0.0039001238,0.10556944,0.016810928,0.031268585,-0.0633201,-0.06934281,-0.032194242,0.09961706,-0.00010591186,-4.6263246e-08,0.020837339,-0.06976201,-0.026967153,0.0029768222,-0.092825904,0.034859303,-0.066410266,-0.0096638445,0.043174207,-0.034774456,-0.0066532115,0.008062145,0.03990467,0.020659033,0.005200774,0.048145574,0.010399803,0.022050245,-0.011168464,-0.076978676,-0.023490252,0.01656448,-0.027913962,-0.003868742,0.014971237,-0.07594948,-0.026859047,0.05283093,-0.0237154,-0.037384767,0.021297641,-0.010419456,-0.004489713,0.032318074,0.044911113,-0.015526261,-0.05842686,-0.05693174,0.04253079,-0.01156868,0.07167721,-0.0436193,-0.050693955,-0.042163156,0.044913344,0.00018807343,0.006635202,0.050309286,-0.029449996,-0.059857406,-0.00065613945,-0.014659788,-0.059341297,-0.03567492,-0.055293426,-0.004032664,-0.037101496,-0.060278654,0.048662867,-0.0876295,0.07937039,0.005198218,0.07522418,0.0069742193 +3.4.21.107,"This serine endopeptidase is essential for the clearance of denatured or aggregated proteins from the inner-membrane and periplasmic space in Escherichia coli. Natural substrates of the enzyme include colicin A lysis protein, pilin subunits and MalS from E. coli [3]. The enzyme has weak peptidase activity with casein and other non-native substrates [3]. The peptidase acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures [1,6]. Molecular chaperones and peptidases control the folded state of proteins by recognizing hydrophobic stretches of polypeptide that become exposed by misfolding or unfolding. They then bind these hydrophobic substrates to prevent aggregation or assist in protein refolding. If attempts at refolding fail, then irreversibly damaged proteins are degraded by peptidases such as this enzyme [6]. Belongs in peptidase family S1C.",384,0.99999994,-0.07482271,-0.12509996,-0.014330021,-0.019737644,0.08938695,0.044729963,-0.019395154,0.11538625,0.07290073,0.015608248,0.0016374255,0.05827691,-0.04044521,0.10831181,-0.0038426307,-0.009601376,-0.064666666,0.038526285,-0.03803083,-0.07465164,0.13506652,-0.0048949197,-0.076157115,0.0031729105,-0.05332671,0.016393503,0.026328413,-0.01614939,-0.023727657,-0.0724132,-0.026328973,-0.101340376,-0.032488197,-0.007210308,0.078103,0.073410004,0.0039003904,-0.05941477,0.062439892,-0.054572817,0.030622857,0.054029927,-0.04981331,-0.04292301,0.096609436,-0.031029172,0.0034361223,0.04985053,0.045640305,-0.036441106,0.0007470986,-0.024833733,0.04522734,0.044224646,-0.014380067,0.057839863,-0.05851631,-0.06752119,0.024063038,0.0042671827,0.011888538,0.009715861,0.030822895,-0.057719525,0.009435266,-0.12252118,0.03647068,-0.008767454,0.054316096,0.02224076,-0.05240248,-0.00096149655,-0.058071576,0.09174941,0.040510133,0.02009989,-0.06095784,-0.036089793,-0.028845564,0.042299945,0.035005793,-0.037579235,0.06157601,0.109842636,0.022046175,-7.8545985e-05,0.11018725,0.00066438486,0.07839426,0.014462844,0.04329801,-0.06519268,0.009484374,0.027625818,-0.054141898,-0.058136877,-0.03140728,-0.039111577,-0.027358795,-0.01904349,-0.0071745594,-0.017438717,0.0066221934,-0.035695218,0.02791103,0.024341408,0.03048001,0.07013556,0.06111439,-0.01530728,-0.0066410624,0.010437272,0.055195607,-0.049818523,-0.01713951,0.050557874,-0.0072414647,-0.0028634565,-0.0113714505,-0.005988658,0.028373528,0.047919974,0.036652148,0.061915495,-0.029103719,0.040368233,-0.10773518,4.4659943e-33,0.01706337,-0.03668071,0.0002099783,0.03033952,-0.022844806,-0.048601013,-0.060974505,0.008399247,-0.004486298,-0.016123407,-0.0028224017,-0.016600683,0.013405364,-0.012664898,-0.03110001,-0.012043587,-0.024785811,0.0406762,-0.006155679,0.010478174,-0.052953515,0.08181065,0.09199794,-0.06619496,0.046544533,0.00627484,-0.043284595,-0.0048442804,0.018223295,0.006351125,-0.074505106,-0.07102065,-0.10730911,0.06039323,0.030378621,0.022278367,0.031884287,-0.07917608,0.00719893,0.03475231,-0.018304145,0.022755856,0.013335121,-0.0118443435,0.06830138,-0.08465719,-0.008509153,0.064631425,-0.09970806,-0.002992394,0.029726878,-0.020570032,0.055388168,-0.041681256,-0.07191538,0.0066799303,0.03958646,-0.02524122,0.081477106,0.029562093,0.03918787,0.033765044,-0.08587673,-0.024394764,0.030118657,0.03622114,-0.025538823,0.00915517,0.02844512,0.10980987,-0.115896076,0.04428111,0.030798096,0.07548529,0.032325536,-0.10411318,-0.05278297,0.05370022,0.047685225,0.02537196,0.06720328,-0.034843326,-0.051091656,-0.012360154,-0.09617974,-0.040723443,0.06346011,-0.027238883,-0.050467554,0.040044047,0.006681796,-0.08500437,0.03882183,0.10609028,-0.042481583,-4.7397615e-33,0.07541997,-0.13164034,0.023610393,-0.02846008,-0.12736726,0.021974647,-0.0019265399,0.047112048,0.03148131,-0.0966477,-0.006853868,-0.081531025,0.038957786,-0.047691867,0.00087894703,0.038901296,-0.07497703,0.010772748,-0.004355115,-0.039578088,-0.073531665,0.052279744,0.03036185,0.061829206,0.01518027,0.042577446,-0.034226768,0.03244787,0.02176373,-0.00022313112,-0.010170414,-0.0782686,-0.034656238,-0.028830055,-0.10827486,0.0383653,-0.059183136,-0.008621735,0.120701045,-0.08826033,0.026935205,0.05264985,-0.0020993445,0.091438085,0.028068634,0.030708348,-0.057138138,-0.007867366,0.008432182,-0.04725934,-0.015054414,-0.10306843,-0.011099255,0.008604773,0.0068210745,-0.02772551,0.0030823348,0.038819708,-0.003254343,0.06861781,0.0064561837,-0.036634337,-0.020242346,0.045618467,0.031604193,0.014240238,-0.06009367,0.013458263,0.09140391,0.0013820311,0.08049928,0.009997981,0.044045947,-0.020122413,0.05525034,0.060591955,-0.11248015,-0.04619495,0.0064302627,-0.023870848,-0.07956393,-0.0025811284,-0.09790602,-0.021555487,0.08994344,-0.031887695,0.029532693,0.09038026,0.021103168,-0.017311545,0.0312778,-0.088007815,0.06651454,0.094550416,0.025565388,-4.2930207e-08,0.05667265,-0.03309888,0.028597172,-0.021985177,-0.053560764,-0.0035113164,0.024536844,-0.03210405,0.0079958895,-0.054140784,-0.0016833363,0.09294457,-0.04058486,0.0608144,-0.012620955,0.068815656,-0.043980755,0.063520946,0.0125614945,-0.011303357,-0.076045,-0.008817235,-0.071488276,0.019524029,0.030844586,-0.01590546,0.024134902,0.03799626,-0.045987632,-0.021437041,-0.027403768,7.832938e-05,0.004046962,-0.009383437,0.016608736,0.06535422,-0.06270552,-0.012085812,0.020296259,0.009099392,0.07028331,0.015651379,-0.076819114,-0.046566874,0.016337587,-0.005043952,0.018038698,0.033489853,-0.06509823,0.007057743,0.10017166,-0.041138124,-0.0021082712,-0.023545403,-0.13811195,0.015574694,0.007017129,-0.061025072,0.031650797,-0.058744427,-0.018329466,-0.034243394,0.10651623,0.026125053 +3.4.21.108,This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment [4]. It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP) [3]. Belongs in peptidase family S1C.,384,1.0,-0.046387743,-0.054608498,-0.085775554,0.030428395,0.058912706,0.0041011306,-0.0071625123,0.0981697,0.03858999,0.0643764,-0.05809772,-0.006226592,0.06937396,-0.0042068553,0.006044872,0.052938677,-0.022836525,0.030019749,-0.023364553,-0.106819555,0.023520056,-0.0037329358,-0.013064471,0.044341847,0.032407068,-0.018856946,0.019118365,0.05025392,-0.068928674,-0.02275081,0.00201077,-0.13662803,0.020387296,-0.003089298,0.039951667,0.047873817,-0.030549413,-0.036420316,4.2278145e-05,-0.029819768,0.018432835,-0.021295257,-0.025114598,-0.02349464,0.09566728,0.008500763,-0.054080117,0.03573007,0.045110848,0.030618751,0.0111009795,-0.0013990261,0.021870477,-0.023661917,-0.018884744,0.03545876,-0.024535209,-0.03794346,0.011330677,-0.009416375,-0.012945842,-0.018743476,0.009613489,0.025662886,0.01017625,-0.05753927,0.040872116,-0.0619575,-0.0394892,0.027476441,-0.029128507,-0.06446284,-0.006171562,0.032557253,0.060807515,0.03261877,-0.015481801,-0.07378097,-0.016938174,0.007441143,0.1490603,0.010216956,0.059590157,0.066636115,-0.024623176,0.020448927,0.08762437,-0.017202312,0.050889112,0.013375288,0.020599574,0.006943046,0.0065813405,0.03583134,-0.08410571,0.031282395,-0.08027831,-0.01096216,-0.12133821,-0.040362794,-0.019573823,-0.07948499,-0.09112438,-0.054943066,0.027195808,0.050066225,-0.022392021,0.03499334,0.083403364,0.032509223,-0.029918697,-0.048996735,0.004633318,-0.05752688,-0.007309902,0.14488098,0.03158662,-0.0059835073,0.025665848,0.03660271,0.025578475,-0.014883607,-0.01971324,0.04077675,-0.07127222,-0.06042981,0.005711876,3.4121552e-33,0.020437455,-0.014543994,-0.052713256,0.06383627,0.039495964,-0.0042581484,-0.048007384,-0.07155247,-0.012686145,-0.09316008,-0.029874,-0.05154683,-0.011912595,0.007000153,-0.07855809,0.046592385,-0.039730415,0.0029709043,-0.024434064,-0.04084072,-0.05681783,0.029215133,0.0132653555,0.009396411,-0.018169984,0.06152698,0.00019616855,0.03888094,0.038267612,0.006584045,-0.12518658,-0.038950767,-0.09313308,0.022676867,-0.049675245,0.024142379,-0.055554964,-0.017345773,0.020288866,0.102836125,-0.069754764,0.014716239,-0.010866343,-0.003644249,0.04890887,-0.05926328,-0.0045229536,0.106801786,-0.085101716,0.023178894,0.06656835,-0.07241136,0.10427802,0.051502597,-0.04129753,0.04384236,-0.03412039,-0.025741577,0.046831694,-0.0059735007,0.060585745,-0.034757476,-0.030268362,0.037204456,-0.03859869,0.013362559,-0.04348092,-0.110939264,-0.0065598385,0.069590144,-0.03630982,0.016234657,0.015727608,0.020006064,0.020494102,-0.098037414,0.063970566,0.10621697,-0.035288755,0.044353545,0.013321085,-0.07807579,0.010406208,0.029737093,0.0066513955,-0.03715405,-0.0019043189,-0.0030635041,-0.07563822,-0.032661136,0.065464325,-0.054368086,-0.038129635,0.11261263,0.0038377175,-4.6532576e-33,0.0638127,-0.09467763,0.06512927,-0.046770766,-0.08925392,0.063889876,0.016894965,-0.022526987,0.024881722,-0.027445965,0.06098741,-0.10989003,-0.04303639,-0.057895586,0.07667868,-0.05344878,0.016240409,0.07540428,-0.061138958,0.06506227,-0.085470416,0.043002818,-0.03464539,0.09081147,0.0065878956,-0.054675385,-0.06968026,-0.00934878,0.061136562,0.014086344,-0.0019671996,0.021279484,-0.05100336,0.036689408,0.015699755,0.01219641,0.02310211,0.015248462,0.009947256,-0.0875774,0.06147538,0.07166582,0.0032049029,0.05203368,0.051008526,0.049043648,-0.033357214,0.005450227,-0.060674723,-0.028686084,-0.0031648113,-0.06670571,-0.012240293,0.046845112,0.06369491,-0.010202694,0.009951662,0.016977973,-0.0121363485,-0.01926339,-0.050728235,-0.00436531,0.010788542,0.086240746,0.10118108,0.08973768,-0.065272175,-0.037296347,0.007375668,0.04335637,0.11104835,0.00457749,-0.087209135,-0.019176941,-0.014778077,0.0634482,-0.05170158,-0.01736277,0.021069463,-0.029664911,-0.03241742,0.03249383,0.0096476665,-0.010239733,-0.019482894,-0.033971477,-0.019674074,0.11876204,0.03767244,0.02118831,0.037494786,-0.057753004,0.038516913,0.04478529,-0.0007888727,-4.316243e-08,0.07761693,-0.017769398,-0.0067527513,-0.077200286,-0.080097355,-0.01325338,0.0018005387,-0.0025245196,0.073873095,-0.011860897,-0.023780188,0.12349748,0.020937383,0.07737006,-0.017884886,0.07899029,0.044103574,0.053104624,0.054672964,-0.0009812857,-0.10546281,-0.060258612,0.009740426,0.018793741,0.06740709,-0.020622374,0.05907985,0.067224056,0.073434465,-0.072575666,-0.067460395,-0.06979982,-0.025142143,-0.039536804,-0.019383263,0.084184736,-0.004264114,-0.027189525,0.0034282804,0.049671173,0.028370965,-0.005536392,-0.015826995,-0.09293287,0.004636998,0.01815192,0.023417301,-0.033851318,-0.061708964,0.009765083,-0.040231206,-0.015854655,-0.03416442,-0.037023105,-0.1265112,-0.04179429,-0.038853183,-0.040089317,0.11776252,-0.11697367,0.060580604,0.0058662766,0.08204978,0.024080511 +3.4.21.109,"This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis [1,2]. The enzyme can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain forms at an Arg residue to give active alpha- and beta-HGF, but It does not activate plasminogen, which shares high homology with HGF [1]. The enzyme can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade [1,2]. Hemojuvelin has been shown to be a physiological substrate for matriptase-2 [5]. Belongs in peptidase family S1A.",384,0.99999994,0.013425607,-0.054545958,-0.0897612,-0.093385406,0.09132941,0.009117014,0.024468388,0.10660875,-0.011856319,-0.004061188,-0.032993756,0.01268709,-0.032739412,0.093667336,0.008462376,0.019514184,-0.093107715,0.026900465,0.029071035,-0.072412744,0.05612618,-0.011760336,0.00054639677,0.017155008,-0.06367633,-0.036435887,-0.0063424273,0.057518527,-0.03495258,0.021919876,-0.04656844,-0.05850802,-0.02587769,-0.05042088,-0.00033514312,0.020829273,-0.0033641036,0.007916357,-0.04433945,-0.03649273,0.06562348,0.009048752,-0.08383772,-0.008403242,0.010292097,-0.08649166,0.0031686004,0.049730826,0.06361037,0.014980636,-0.08572213,-0.051289577,0.016253427,0.020450907,0.094665885,-0.015170605,-0.0751355,0.010871483,0.12065581,-0.084434405,-0.07201499,-0.08546581,0.113248475,-0.0441761,0.04514615,-0.044771384,-0.02655476,-0.005130321,-0.033785038,0.058610685,0.0011495248,0.03048801,-0.07778576,0.06622781,-0.008211553,0.05693788,-0.03945556,0.01998465,-0.0071398425,0.02378502,-0.010868231,-0.030803662,0.06634759,0.12301858,-0.021044737,0.02642503,0.018544596,-0.024646394,0.041188493,0.014948155,0.077251576,-0.0037388334,-0.017807854,0.05388669,-0.049898513,-0.046785954,-0.09075268,-0.021365453,-0.015636021,-0.020273685,-0.010959101,-0.011534994,-0.00078801496,-0.057465535,-0.025481995,0.047771513,-0.044185948,0.09846861,0.06396079,-0.00026607697,-0.00434012,-0.029930623,0.067015015,0.008129587,-0.016748711,0.10639109,-0.00092982274,-0.016213901,-0.04869077,-0.0077052345,0.043793958,0.08555657,0.017539864,0.049132664,0.010469422,0.035269212,-0.12156986,2.3370494e-33,0.009349399,-0.021980902,0.06833806,0.05735478,-0.032513607,-0.061287392,-0.022355566,-0.021610845,0.010008194,-0.025853803,-0.07681866,-0.0198531,-0.029414646,-0.03606052,-0.05743456,-0.03116071,-0.0054289773,0.010380429,0.02252729,0.03941422,-0.015059196,0.074617945,0.05384661,-0.0818529,0.06409702,-0.005046255,0.019314416,0.057868946,0.086349286,0.00844935,-0.090949826,-0.12950806,-0.04270213,-0.00787517,-0.013091843,-0.03187875,0.035098605,-0.012612355,-0.047134336,0.0014074087,0.021855667,-0.03301442,-0.05495146,-0.02924147,0.05259764,-0.052339092,-0.010462281,0.056055564,0.0083761625,-0.00041089355,0.015395525,-0.09832515,0.078850515,-0.01793584,-0.05610112,-0.049755458,-0.05548183,0.026927598,0.058549732,0.045409005,0.05362079,-0.090688296,-0.008191626,0.097782195,0.0074480297,-0.00968163,-0.03868806,-0.032420225,0.00236411,0.06891608,-0.02024304,0.071904205,0.06381805,0.030380746,0.02604844,-0.07804425,-0.015090209,0.059239723,0.03871606,0.09330034,0.007553297,-0.053989816,-0.10177604,0.033398215,-0.06003293,-0.05709427,0.030053616,-0.043254886,-0.08153167,-0.00574832,0.026180422,-0.058831684,0.015975216,0.06776146,-0.021305809,-4.3054207e-33,0.03687922,-0.073969625,0.1325624,-0.08690337,-0.018875025,0.09818228,0.08197135,0.0203624,0.041878834,-0.03228143,0.027700461,-0.052248783,-0.033894975,-0.0733432,-0.060781356,0.0015545711,0.01219617,0.04177596,-0.051633585,-0.07056032,-0.093165316,0.07054844,0.035168942,0.062048767,-0.035898343,0.053224273,-0.02140255,0.07926099,-0.018040229,0.0711278,-0.011316028,0.028467651,-0.079371095,0.021602366,-0.024309665,0.04796711,-0.008922632,-0.017526997,0.06488093,-0.042087387,-0.037125587,0.02165781,0.068891354,0.058978897,-0.046181846,0.13683958,-0.02320937,0.09292845,-0.038684078,-0.077361576,-0.03625876,-0.016897654,-0.029883912,0.05681268,0.02201241,0.04391694,0.048324194,0.056048725,0.0035586068,0.0756691,0.0018286763,-0.06115425,-0.06516062,0.030372487,0.009568429,0.089681216,-0.039977368,-0.10475527,0.07187312,0.04537309,0.075785875,0.024027158,-0.01008642,0.07115742,-0.027664855,0.032141875,-0.0077396655,-0.09050734,-0.014954219,-0.057603385,-0.0850033,-0.013125738,-0.019214885,-0.03244821,0.035219498,-0.039583012,0.017100628,0.062343653,0.011779469,0.02371031,-0.019330885,-0.024729293,-0.018479949,0.09357988,-0.019354474,-4.5699437e-08,0.023559654,-0.08684151,-0.00833841,-0.091376215,-0.03635192,-0.0008843125,-0.04168292,0.0050040283,0.034576494,-0.034062125,-0.020345379,0.020368667,0.008213008,-0.017469075,-0.007868429,-0.027597586,0.025944164,0.06580508,-0.007981122,-0.089003436,-0.02687003,-0.022578422,-0.053330995,0.0377619,0.044104733,-0.087555796,-0.03847112,0.06630994,-0.017405363,-0.048584443,0.07345857,-0.030240295,0.01684218,0.02936843,0.012698708,0.09298842,-0.05143905,-0.02882697,0.027149888,-0.010410717,0.036927763,-0.07327429,-0.009793208,-0.08084175,-0.034187697,-0.022014344,0.0021042018,0.033410553,0.010715218,-0.011592105,0.07713233,-0.0026887502,-0.01678557,-0.07522701,-0.074118875,0.031576466,-0.019323861,-0.024137136,0.050290808,-0.04944798,0.07751435,0.0004918713,0.10432853,0.03721175 +3.4.21.110,"This enzyme is a surface-associated subtilisin-like serine peptidase with very specific substrate specificity. Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a. Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties [1,4]. Belongs in peptidase family S8A.",384,1.0,-0.014376713,-0.06580127,-0.09656225,-0.0243111,0.042242676,0.052204426,-0.028583417,0.1612053,0.03930228,0.023126325,-0.058997195,-0.018640796,-0.02382218,0.1060788,-0.047941443,-0.026493495,-0.02717664,0.0076092277,0.024128627,-0.057522822,0.02608848,0.03613465,0.008129681,0.01101272,-0.085078,-0.012140917,-0.01292555,-0.05349982,-0.036112927,0.015659476,-0.051387884,-0.046254706,0.04414375,-0.039723016,0.06913241,0.027318072,-0.07635847,0.013878925,0.07944423,-0.011440979,0.012242917,-0.012299059,-0.067026936,-0.019677421,0.06461067,0.007161476,0.032126587,0.06368005,0.09558139,0.0036383078,0.033375278,-0.009959235,-0.026827728,0.0189142,-0.05609765,-0.026109159,-0.044476036,-0.080603145,0.093575954,-0.040261082,-0.020901505,-0.014489667,0.09220593,-0.021032209,0.015663425,-0.08506633,0.026132474,-0.035942882,0.03780292,0.03502268,-0.07209732,0.0046243975,-0.030871367,0.10448603,0.013152789,0.04791178,-0.017344145,-0.08830043,-0.020602997,0.021979714,0.07269006,0.060116824,0.0034357996,0.12814713,0.027975917,-0.004821336,0.04134149,-0.032210782,0.044013932,-0.05841219,-0.010398981,-0.008973788,-0.03315824,0.014071863,-0.104359545,-0.09724746,-0.07984501,-0.013100592,-0.020575188,0.021128057,-0.01566121,-0.043806646,0.02264633,-0.00039286882,-0.02430321,0.035524383,-0.057134885,0.033587184,0.08845955,-0.034576207,-0.020108262,-0.003531965,-0.03680978,-0.11011057,0.048251975,0.02419795,0.056442373,-0.02196656,-0.015141205,0.02426455,-0.014276387,-0.00942206,-0.017783336,0.029458681,-0.017022373,-0.02032886,-0.068425074,4.724599e-33,-0.028397849,0.005361282,0.096397415,0.025574697,0.028202504,0.0039830655,-0.013071051,0.0074165533,0.0022402722,-0.037876904,-0.085312955,-0.11125379,0.030273007,0.05829039,-0.052967843,0.02603781,-0.008963915,-0.035906546,0.027803818,-0.03705679,0.007758047,0.063724406,0.0033891876,-0.06137288,0.09107705,0.04575625,-0.016724277,0.06639081,0.043805923,-0.030946804,-0.035557605,0.018341662,-0.072624296,-0.02416301,0.06565308,0.011327332,0.0443179,-0.017615024,-0.025604574,-0.011332239,-0.048073363,0.04284942,-0.032180455,-0.06268965,0.08155415,-0.07651736,-0.08477191,0.038422327,-0.02759845,0.048161432,0.11497037,-0.02104135,0.012808189,0.028313579,-0.057191823,0.0065006157,0.00966895,0.008101404,0.10560686,0.056745347,0.07394148,-0.0019073263,-0.057783514,-0.016626887,0.003388411,0.07882109,-0.02508769,0.028349273,0.027455889,0.0370853,-0.07719551,0.062703274,-0.021072429,0.08399937,-0.023923632,-0.058756996,-0.006890882,0.12231795,0.096090175,0.08793375,0.03178802,0.031253908,-0.028004015,0.02742619,-0.091980346,0.010175329,0.061973974,-0.09664287,-0.061029293,0.0097805085,0.05743955,-0.13343622,-0.0255977,0.09142476,-0.031626757,-6.858855e-33,0.04785137,-0.13323358,0.02390994,-0.06523598,-0.07540117,0.025031412,0.0028781074,0.0154737085,-0.05942333,0.021150349,0.0846052,-0.008618359,0.03279472,0.048115183,0.037759837,0.010075858,-0.028740961,0.073278435,-0.047591288,0.029082417,-0.0060422476,0.05197928,-0.012157815,-0.004208432,0.06753636,-0.0061455993,0.005578903,0.059122946,0.0109427,-0.027794411,-0.049790088,-0.002676957,-0.09781976,-0.041529637,-0.03838049,-0.015397912,-0.028362054,0.06962525,0.09247979,-0.08164307,-0.0033106627,0.028130801,0.070694335,0.12054491,0.024402332,0.057952918,-0.019345116,0.028484441,0.03708128,-0.010508106,-0.015226159,-0.04626811,-0.027391994,-0.018164217,0.047907352,-0.020543262,0.07364659,-0.0386024,0.021098806,0.0064533325,-0.009697473,-0.04031746,-0.027595328,0.06758901,0.053010687,0.029613648,-0.040309895,-0.028901603,0.106829636,-0.08084217,0.024127841,0.007212417,0.041343328,-0.033662573,-0.034070488,-0.017897613,-0.056604963,0.07735063,0.026892142,0.042861264,-0.03140678,-0.11965024,0.018788131,-0.022940854,0.028592002,-0.054829907,0.014018167,0.0070610004,0.030887974,0.016453639,-0.02328663,-0.01703449,0.02628499,-0.018570991,-0.012617279,-4.0135685e-08,0.07304853,-0.058033887,0.017381595,-0.09554129,-0.037013613,0.011524489,-0.10395458,-0.10776693,0.020855615,-0.030657785,0.03221835,0.00066596735,-0.0096046245,-0.0034381195,-0.04047836,0.06865311,-0.0866898,0.0053017717,0.04408423,-0.008348141,-0.1454996,-0.013108211,-0.06449826,0.03513598,0.07707949,-0.1074932,0.019944556,0.064669974,-0.029345129,-0.043985758,-0.010285897,0.023357712,-0.07255063,-0.020547258,0.02128914,0.009297122,-0.019758001,-0.023456797,-0.029119324,-0.017687893,0.06955838,0.0286073,-0.040935177,-0.049478516,0.04291799,0.038207926,0.04124817,-0.017705327,-0.07534905,-0.06395969,0.048836302,-0.036275767,-0.022670714,0.036973704,-0.08273655,0.024294084,-0.023863817,-0.060588643,-0.002478415,-0.037939355,-0.05164215,-0.025913399,0.104693644,0.024755972 +3.4.21.111,"This enzyme from the extreme thermophile, Thermus aquaticus, is an alkaline serine peptidase. It has three subsites, S1, S2, and S3, in the substrate binding site. The preferred amino acids at the S1 site are Ala and Phe, at the S2 site are Ala and norleucine and at the S3 site are Phe and Ile [3]. These specificities are similar to those of EC 3.4.21.64 (peptidase K) and EC 3.4.21.62 (subtilisin BPN') [3]. The enzyme displays broad specificity for cleavage of insulin B-chain and hydrolyses elastin substrates such as succinyl-(Ala)n-p-nitroanilide (n = 1,2,3) and some peptide esters [1,3]. Belongs in peptidase family S8A.",384,1.0,-0.0702995,-0.07633512,-0.14261003,-0.045863908,0.10319527,0.07738282,-0.013672775,0.043859646,0.025281772,0.011390115,-0.022708543,-0.07135189,0.0077277124,0.08182837,-0.028370073,0.0018454565,-0.08806592,-0.061554622,-0.007929108,-0.07458694,0.11995626,0.05130723,-0.0007887667,0.054486316,-0.0041993516,-0.0064333137,0.049927346,-0.024087433,-0.046967138,-0.035772365,-0.02332401,-0.10297191,0.085159026,-0.051830325,0.05249877,0.023770552,-0.021542583,-0.07772009,0.0016354349,-0.0045473785,0.08475239,0.023680164,-0.05159025,-0.032179855,-0.0074559655,-0.039692808,0.010328334,0.006979809,0.034687992,0.0070043853,-0.03157792,-0.14254254,0.009086908,0.027199607,-0.012222919,0.023923472,-0.11975929,-0.028839134,0.047632147,0.0128681045,-0.010519378,0.025590045,0.05684383,0.017724082,0.060215123,-0.03252971,0.004962117,-0.038327638,-0.006696572,0.028038353,-0.06570867,-0.06436614,-0.08804498,0.115439765,0.043957096,0.03447127,0.031973056,-0.042358287,-0.070870206,-0.0352353,-0.018277528,-0.0015137199,0.06801355,0.10548396,0.050016068,-0.025969027,0.06925922,-0.015049377,0.072111055,-0.018157072,0.059060343,-0.067378856,-0.0072398256,-0.016701689,0.0007484266,0.007814943,-0.089302175,-0.028287567,0.016095394,0.005524119,-0.0007033731,0.055906117,-0.016113603,-0.06419394,-0.019015266,0.058874987,-0.015149583,0.06595798,0.06479645,0.0012498626,0.0120860515,0.0029336098,0.06567743,-0.0006442399,0.0130175445,0.06722523,0.0023087424,-0.014403735,-0.01024931,0.044833314,-0.002090542,0.021447511,0.08662703,0.054830533,-0.031069417,0.14615674,-0.10841867,2.6027232e-33,0.06358397,-0.08706195,-0.00039337983,-0.0020029352,0.04178765,-0.043173697,-0.07944199,0.054967757,0.007888963,-0.03362956,-0.10111607,-0.01783258,0.032968212,-0.022815516,-0.0048219687,-0.01949273,0.04148977,-0.00022139338,0.035137977,0.043395575,-0.01733078,0.041585647,0.03411406,-0.0681045,0.06922735,0.011920399,0.047837522,0.033792254,0.096750595,-0.011403698,-0.0067359977,-0.08828,-0.0968137,0.011470563,0.030224755,-0.010000121,0.025806898,-0.022945829,0.00953263,0.0796446,0.03178953,0.0105879335,0.021109061,-0.022289077,0.049723,-0.030410886,-0.019058272,0.06873143,0.06219316,0.032801967,0.030648546,-0.04782256,0.077851325,0.051868856,-0.078154325,0.012507655,-0.035811495,0.009369202,0.056634866,0.009874164,0.011090539,0.023050034,0.019331554,0.00272405,0.01481307,0.06841778,-0.10362853,-0.03270185,0.0017600254,0.028516991,-0.08910946,0.04240977,0.082623444,0.05567947,0.07157358,-0.07098303,-0.024634955,0.040485036,0.02101559,0.058596063,-0.020450182,0.029747669,0.0085075805,0.029265579,-0.085919745,-0.07994518,0.023596302,-0.049358148,-0.056482583,0.01451415,-0.026276886,-0.074669346,-0.01686227,0.0226515,-0.030194042,-4.080981e-33,0.066936165,-0.14225563,0.08477523,-0.09891486,-0.08589184,0.012138777,0.094328575,-0.004797632,-0.0016139532,-0.039219126,0.0682706,0.024462458,0.054526392,-0.062627755,0.053860098,0.03633425,-0.041916784,0.032476828,0.008592361,-0.06354107,-0.06889492,0.07587672,0.019008579,0.01545905,0.047877077,0.009110225,0.01943648,0.100565456,0.03703002,-0.021028372,-0.06701655,0.055846475,-0.051760755,-0.017295063,-0.11713927,0.06337012,-0.0460874,-0.023539392,0.0003364623,-0.06018586,0.023582635,0.062846966,0.050132442,0.059040695,0.050206643,0.056653876,-0.04393339,0.019132623,-0.00081612536,-0.04009258,-0.042913903,-0.07699937,0.01390818,0.0041487985,0.044983603,-0.041043393,-0.021850344,-0.008110521,-0.026941251,-0.016939268,0.023473354,-0.005684472,0.007321984,0.016814345,0.011149798,0.043063432,-0.05722839,-0.043485288,0.08158641,0.018770397,0.07243594,-0.07191131,0.05140109,0.020202503,0.007055692,0.02300344,-0.064685725,-0.0068593463,-0.01513596,-0.12536246,-0.020589545,0.018652316,-0.05039209,-0.08685699,0.019748893,-0.013860983,0.07148277,0.07645307,0.03642296,-0.009799126,-0.024533754,-0.02548219,-0.026283724,0.047938447,0.052955408,-5.0600963e-08,0.10025344,-0.060309306,0.04289039,-0.0031686844,-0.017197248,0.019185591,-0.03204938,-0.058506537,0.03794197,-0.10496372,-0.016497232,0.023180429,-0.032836635,0.0027432966,-0.03197892,0.024038387,-0.059542835,0.060407236,-0.016130092,0.027476111,-0.09013764,-0.0044305027,-0.10301019,0.008135987,-0.00741167,-0.063141786,-0.017004509,0.04549035,-0.01692098,-0.06724246,-0.0010598579,0.005876133,0.01306148,0.027434645,0.013828943,0.004872976,-0.054310113,0.010320458,-0.005796656,0.061591275,0.06964173,-0.08356132,0.010057722,-0.031516008,8.8165376e-05,-0.01097179,-0.019902766,0.046345364,0.0025073683,0.0070338775,0.035987865,-0.06242653,-0.02575046,-0.03659629,-0.09156244,-0.059749328,-0.05443598,-0.103653185,-0.017636757,0.02292059,0.00010275919,-0.036235858,0.1321569,0.03685294 +3.4.21.112,"Cleaves sterol regulatory element-binding proteins (SREBPs) and thereby initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholesterol and unsaturated fatty acids into the bloodstream [1]. The enzyme also processes pro-brain-derived neurotrophic factor and undergoes autocatalytic activation in the endoplasmic reticulum through sequential cleavages [5]. The enzyme can also process the unfolded protein response stress factor ATF6 at an Arg-His-Lys-Lys! site [4,8], and the envelope glycoprotein of the highly infectious Lassa virus [5,8] and Crimean Congo hemorrhagic fever virus at Arg-Arg-Lys-Lys! [7,8]. Belongs in peptidase family S8A.",384,1.0,-0.080505066,-0.09778246,-0.10981533,0.01768759,0.059093032,0.049568,-0.0189342,0.048598636,0.035931043,0.01127445,-0.025118303,0.057120126,-0.07559628,-0.008210447,0.029583931,0.003890887,-0.109200284,-0.060717985,0.002432424,-0.026445119,0.07294234,0.054027323,-0.0468465,-0.02541294,-0.0071110446,0.006776189,0.043031506,-0.0019564372,0.010999344,-0.02369485,0.027425556,-0.075868875,0.013938067,-0.07347149,0.030352464,0.13297921,-0.032075193,-0.10417226,-0.06873393,-0.009085065,0.08243818,-0.02449893,-0.026822822,0.008167601,0.06897658,-0.012633945,0.0063175075,0.05310906,0.08958282,-0.030544152,0.021616284,-0.111005105,-0.006135981,0.001964241,-0.05270051,0.06897778,-0.059831206,-0.03482593,0.015207973,0.045916606,-0.09817503,0.018064914,0.017852413,-0.012417847,0.02309363,-0.09541839,-0.0084156925,-0.020534836,-0.050628792,0.047314297,-0.027166622,-0.003945092,-0.1650973,0.079105765,-0.01527041,0.07267545,-0.042960223,-0.061322965,0.062847294,-0.023320103,0.032926124,-0.0097744195,0.12619327,0.09606584,0.021662919,-0.0054614022,0.049852096,0.007144492,0.0002050552,0.071493514,0.09043994,-0.08883053,0.06007249,0.07869025,-0.0726848,0.07011207,0.063288935,-0.0513143,0.002645279,-0.030767025,-0.025144003,-0.028941035,0.031715985,-0.0108699715,-0.0026074115,0.025870651,-0.027745306,0.09468955,0.020820323,-0.011062604,-0.03272684,0.012267665,0.1358927,-0.03184775,0.03642853,0.03973204,-0.049292333,-0.03513775,-0.027260164,-0.06787415,0.0059061674,0.0370805,-0.004543975,0.034573104,0.008204967,0.05492745,-0.053302612,4.401175e-33,0.026029952,-0.04597121,-0.016085278,0.051287834,-0.058984287,-0.032926664,-0.04596392,0.043922104,-0.028709235,-0.0070969076,-0.032301176,-0.08888685,0.038033128,0.07089293,-0.046811894,0.0025684242,0.009836899,0.08254094,0.09093679,-0.019878903,-0.032468796,0.06514974,0.07579787,-0.096794404,0.061086603,0.014723148,-0.015164973,-0.01341906,-0.0049947463,-0.0030915067,-0.057102785,-0.059418708,-0.080550544,-0.003879955,0.004011271,-0.009983526,0.0041313684,-0.074295856,-0.07574912,0.07713933,0.10722901,0.03490064,-0.096967384,-0.00566006,0.044875536,-0.049570285,-0.022128146,0.038673908,-0.0004965499,0.021224681,0.029053563,0.01744986,0.08481233,0.02821537,-0.049314715,0.037184894,0.018254863,0.02258281,0.034074962,-0.008953757,0.066624284,0.113756925,-0.009677309,0.03704394,0.02135821,-0.0096254805,-0.022535179,-0.052655805,-0.013532471,0.06521485,0.015299595,0.054234013,-0.0035903628,-0.02038852,-0.0038633423,0.000345088,-0.046575032,-0.003093038,-0.009668436,0.020160686,-0.060808275,-0.00689211,0.060622264,-0.017048545,-0.033027247,-0.02159756,0.009894485,-0.0794049,-0.06354013,-0.024204075,0.041823223,-0.026584703,0.0049110465,0.054381814,-0.07794353,-3.6395373e-33,0.0462458,-0.13065572,0.06382726,-0.04623879,-0.0066276235,0.07314612,0.014080465,-0.06951494,0.022658782,-0.095334016,-0.0006889235,0.008435536,0.008501031,-0.030503137,0.07623666,-0.018045241,-0.065512784,0.07492373,-0.060758885,-0.045283515,-0.073824435,0.023566527,0.030337866,0.087941766,0.03363098,-0.027416028,0.036102217,0.015626991,0.019540185,0.025823481,0.023526952,-7.4774675e-06,-0.02892755,0.022803895,-0.06377957,0.032043304,-0.0043752287,0.0013564106,0.04959529,-0.06228947,0.06176569,0.09043988,-0.04103155,0.0014311527,0.036088634,0.0011009013,-0.029999385,0.050367896,0.025174709,-0.022413474,0.00092504756,-0.095348164,0.02504608,0.07557447,0.003663938,-0.013453375,0.023238463,-0.010922314,0.052213587,-0.080249175,-0.031522155,0.01023361,0.005011132,-0.032755706,0.10886971,0.099147215,0.039926864,-0.037916932,-0.021510161,-0.0621585,0.07435275,0.005690825,-0.02013864,0.06530965,0.04893108,0.056791034,-0.010449235,-0.011723711,0.032477777,-0.04357605,-0.058172826,-0.035721775,-0.029429689,-0.030066999,-0.011307276,0.037089054,-0.005824208,0.060799927,0.066873945,0.04365438,-0.016822863,-0.043875977,0.00030675044,0.053028118,0.053977057,-4.7495444e-08,0.041248012,-0.07015012,-0.011525221,-0.038329113,-0.027361505,0.00506092,0.04731379,-0.03829289,0.030870926,0.047118384,0.034599192,0.053338498,0.043117914,-0.0024439306,0.00081389653,0.06101589,-0.024363896,0.07095224,-0.025501456,-0.082080156,0.007930325,-0.066511504,-0.029415354,0.05433558,0.07195608,-0.13373108,-0.057342663,0.06659661,0.09513045,-0.09362879,-0.02602364,0.01712921,-0.0062938514,0.020675655,0.032653034,0.055127855,0.047416326,-0.06510425,-0.005235592,0.10382693,0.02710899,-0.05400255,0.009270108,-0.091422305,-0.065691665,0.007795747,-0.009567366,0.0642232,-0.0026250237,-0.016772995,0.012852888,-0.037619006,-0.019540362,0.009890255,-0.10489437,-0.027237331,-0.042900722,-0.033115212,0.047753464,-0.012934191,0.03243869,-0.027119549,0.13241157,-0.0048423205 +3.4.21.114,"In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab polyproteins. This enzyme is the main viral proteinase and processes five cleavage sites in the ORF1a protein and three in the ORF1b-encoded part of the ORF1ab protein to yield nonstructural proteins (nsp5-nsp12) [3]. It combines the catalytic system of a chymotrypsin-like serine peptidase (His-Asp-Ser catalytic triad) with the substrate specificity of a 3C-like serine peptidase (Glu or Gln) at the P1 position and a small amino-acid residue (Gly, Ser or Ala) at the P1' position [1]. Cleavage of ORF1ab by this enzyme is essential for viral replication [2]. Belongs in peptidase family S32.",384,0.99999994,-0.08272841,-0.016323682,-0.013771164,-0.1111422,0.08501179,0.036607593,-0.016805748,0.006571599,0.081267744,0.02479629,-0.010469517,0.023874354,-0.013767771,0.06145668,-0.026536608,-0.042246435,-0.12835914,-0.018951481,0.009314907,-0.0073156874,0.049879003,0.02047782,-0.022207078,0.0070953234,-0.010601213,0.007006216,-0.028032623,0.017455196,-0.018217549,-0.044687733,0.003203921,-0.11161578,-0.012640301,-0.019443313,-0.026036728,0.0036565864,0.0007186525,-0.056647122,-0.093801364,0.0007897094,0.08508295,0.018349255,-0.11873988,-0.011687078,0.059588566,0.0050977464,-0.014691882,0.034944713,0.111673646,-0.012762695,-0.061540857,-0.06477082,-0.06549392,0.02730048,0.0067921877,0.054914296,-0.107552506,-0.010014443,0.009937077,-0.008076675,-0.018972998,0.06682159,0.031527635,0.017478228,0.009193752,-0.0003401648,0.009817342,-0.02253184,-0.04283905,0.03848487,-0.06207548,-0.0643286,-0.11262366,0.052845694,-0.006254442,0.112492375,-0.029083971,0.00015125424,0.05457991,-0.0072762566,-0.039521802,-0.01131817,0.10082974,0.084796295,-0.033042945,-0.017835528,0.048670404,-0.035502475,0.075237185,-0.009174859,0.037899204,-0.052205488,0.009996605,-0.007007231,0.06543204,0.052030206,0.040955365,-0.009411647,0.092460886,0.014018022,-0.031700384,-0.0112655535,0.077706456,-0.06935273,-0.07443096,0.03439343,-0.093507834,0.065175936,0.03622335,-0.03980971,-0.05387812,0.0050610597,0.073206976,-0.04467559,0.023632554,0.07440238,-0.07302022,-0.01931474,-0.04516552,-0.0142368525,0.03488846,-0.016987821,0.07056915,0.07177194,-0.065598495,0.04559124,-0.037944146,4.497152e-33,0.0035285763,-0.030830013,0.04126812,0.01702703,-0.011242798,0.009906931,-0.044471897,0.07358258,-0.030802827,-0.07664562,-0.040754702,-0.07740269,0.044950493,0.022230005,-0.004206515,-0.039729718,-0.0032672558,-0.000972244,-0.006675391,0.04316573,0.03706892,0.05372218,0.014781331,-0.03547634,0.06403049,-0.028078124,-0.07013089,-0.045277447,-0.025191898,-0.018584162,-0.029143142,-0.07937808,-0.09769083,-0.05145545,-0.04870095,-0.006955427,0.009644092,-0.07735488,-0.027998308,0.053088617,0.07796754,0.009826306,-0.0257836,-0.021601096,0.05879088,-0.023631826,-0.06043369,0.08755353,-0.041511178,0.046188015,0.061781906,0.05366935,0.07889508,0.0165887,-0.06919333,0.029129697,0.00026520411,-0.045640558,-0.019140096,-0.049599167,0.063931696,0.030135682,0.07700172,0.0056409077,-0.01652719,-0.032729175,-0.03519345,0.022285562,0.013687201,0.10540723,-0.025477223,0.059376325,0.025081063,-0.04535392,0.012432322,-0.047154818,-0.0857452,0.017159715,-0.0028333848,0.02633408,-0.108543515,0.048964374,0.06580537,-0.0062743947,-0.056906138,-0.03217925,0.059102044,-0.025319977,-0.106672704,0.009459866,0.11215249,0.013015241,-0.010277809,-0.001884711,0.026630618,-5.740491e-33,0.047885694,-0.17345454,0.059763327,-0.04659987,-0.0433583,0.06398206,0.08753214,-0.016535087,0.05176193,-0.00905829,0.00802198,-0.011430935,0.030341271,-0.09246238,0.03253041,-0.051486254,0.001899785,0.117581636,0.018238176,0.008211269,0.011840764,0.04099764,0.04119003,0.050000355,0.05885707,0.011719178,-0.028064921,0.042272113,-0.03999294,-0.005779209,0.006923742,0.06283064,-0.028471436,0.018723821,-0.020000476,0.013127573,0.051285066,-0.045360617,0.03587442,-0.052420124,0.0627184,0.0753739,-0.0011745581,0.021990959,0.00030833244,0.12510324,0.0028097006,0.11722805,0.02926692,-0.0059125633,0.029974842,-0.023826504,0.00021746653,0.011334065,0.005512136,0.047661357,0.027054723,-0.022189548,-0.008209378,0.015353733,0.028688611,-0.025959553,-0.03458445,0.081876196,0.042177547,0.04813843,0.014301484,0.033512726,0.013900437,-0.09272889,-0.005173907,0.0076121995,0.020902047,0.039096244,0.024368677,0.037082903,0.004499477,-0.041614268,0.04154409,-0.08801439,-0.07341589,-0.034896333,-0.023281595,-0.040978245,-0.0034676834,0.006478009,-0.00750129,0.08416211,0.010266623,0.037723776,-0.028531969,-0.055174496,-0.018209642,0.06265813,0.046218257,-4.7186656e-08,0.08917841,-0.0670828,0.02759769,-0.05915119,-0.061243095,0.01305171,-0.04160762,-0.027840596,0.081748724,-0.041790944,0.0639713,-0.0053913966,-0.03168011,0.008274275,0.03911505,0.023578972,-0.0050130268,0.047962047,-0.06463802,-0.08651852,-0.07232143,0.009609385,-0.06881183,0.0032190084,0.023602653,-0.10305703,-0.016684867,0.092758425,0.03221127,-0.08816229,-0.11010727,-0.015441979,-0.024626672,-0.058652785,0.0041659633,0.029784927,0.023823794,-0.01598744,0.04648661,0.020796405,0.029390462,-0.10067049,0.0064764167,-0.06476916,0.016381068,0.010920024,0.03744122,-0.0120885065,-0.0008948987,-0.07131679,0.010877771,0.012493472,0.084524766,-0.08186254,-0.16938002,0.005642734,-0.044957276,-0.04785451,0.033197332,-0.07315356,-0.003200542,-0.009771691,0.14807422,0.005735941 +3.4.21.115,"Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish [2]. As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus [2]. pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2. This cleavage is most likely due to host-cell proteases rather than VP4 [2,3]. Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp [2]. Belongs in peptidase family S50.",384,1.0,-0.030011944,-0.012785807,-0.057316795,-0.076560296,0.08763138,0.047019307,0.018230056,0.08958849,0.05495246,0.020779021,-0.019036695,0.03652971,-0.03145108,0.041454393,-0.04188611,-0.026684089,-0.041687675,-0.0508334,0.035100404,-0.045194875,0.02676763,0.0487682,0.025753843,-0.08764635,-0.06155702,0.038596727,0.027020283,-0.015910491,0.008502346,0.008838396,-0.033755403,-0.061706025,0.045072198,0.011001011,0.0056239334,0.0020477965,0.03414649,-0.0019447801,-0.029373383,0.005263206,0.11139233,0.013667406,-0.028589634,-0.030106543,0.038136754,0.014153617,-0.011888734,-0.032543782,0.05585084,-0.019191407,-0.06155915,-0.057908352,0.058739364,-0.021140108,0.010634746,0.038490903,-0.12698907,-0.09154817,0.014402759,-0.062074997,-0.014527801,0.05931253,0.0049191522,-0.020370446,0.08133572,-0.12066683,0.09366077,0.073992796,0.02450311,0.06394884,-0.026948575,0.030699525,-0.12853828,0.08220138,-0.08493855,0.078780875,-0.0056459964,-0.04935771,0.04234327,-0.017398497,-0.038857233,0.023776183,0.07126473,0.08917581,-0.025267081,0.03712403,-0.0028711546,0.002939952,0.002217287,-0.02382269,-0.03723822,-0.025067473,0.06131254,0.0077210832,-0.009438853,0.051418494,0.02482655,-0.09428653,0.005933485,0.027893895,-0.025063869,-0.014935233,-0.022738686,-0.14959031,0.024291234,0.06277894,-0.036187395,0.09991285,0.050386123,0.006461012,0.04217151,-0.004286053,0.07640723,-0.0921807,0.04673969,0.12315211,-0.057912994,-0.013307847,0.019542903,-0.04080598,-0.026906075,-0.039335795,0.0054493886,0.06336835,-0.1336892,0.029328853,-0.019331718,2.8623912e-33,0.0006791379,-0.04837051,0.053019445,0.036139593,0.0013061396,-0.034829006,0.038271498,0.011309776,-0.01529115,-0.06038325,-0.04608677,-0.092401,0.053273678,0.043108433,-0.06505706,-0.037164662,0.0011096364,-0.0033230856,0.013450872,-0.009065598,0.0131340865,0.052225046,0.12147963,-0.04374519,0.050745487,-0.0625058,-0.016167318,-0.04338389,0.055212315,-0.011776293,0.02521383,0.019999705,-0.0314857,0.07395889,-0.02777105,0.0018771578,0.054703027,-0.04138772,-0.050136328,0.06644452,0.033899132,-0.023889324,-0.055344727,0.015023709,0.0462755,-0.053333346,-0.005745252,0.037533414,-0.050625503,0.029822147,0.021525124,0.04186083,0.03423183,0.014107334,-0.07008175,0.003598745,0.042705007,0.0009030019,0.04469038,0.0036604607,0.009411263,0.056663167,-0.0584839,0.033549495,-0.0006758014,0.002344759,-0.031800054,-0.048678864,0.013586391,0.08356867,0.0024115937,0.003919919,0.00530091,-0.013567607,0.060782883,-0.10294711,-0.09919052,-0.019531377,-0.012052093,0.07143842,-0.050594516,0.08517225,0.04956337,-0.031739645,-0.08846615,-0.036842935,0.060415328,-0.027729485,-0.076772965,0.06666863,0.046934243,0.0026098145,-0.0050217817,0.05179209,0.0016034236,-4.5275484e-33,-0.030073233,-0.085989624,-0.050894335,0.021008862,-0.0559021,0.019407151,0.106505424,-0.035290185,0.0061784787,-0.06939155,0.01219766,-0.026039153,0.0494889,0.0019128361,0.056288134,-0.036566205,-0.0407817,0.09791956,-0.033439074,-0.017472243,0.00031262235,0.07572986,0.02163464,0.10559861,0.07529192,-0.0125834,0.044958033,0.13861279,-0.08945582,0.0374562,0.07708451,0.09118642,-0.06729543,0.011273431,-0.05665011,0.042683344,-0.0039453106,-0.036699843,0.032042865,-0.04493946,-0.051273417,0.010716332,-0.003811011,0.06096248,-0.03092482,0.030470656,0.0111742765,0.07935703,0.05606658,-0.085869186,0.00064375135,-0.037659198,0.019195901,0.031001113,0.050484173,0.024452519,-0.07594969,0.011727403,0.06353424,-0.03544741,-0.009459997,-0.07954422,0.064747624,0.08303869,0.10881877,0.00766775,0.05462442,0.04696119,0.03542366,-0.07984907,-0.040352456,0.060232688,0.0021938228,-0.021206068,-0.0268191,-0.015529218,-0.037188087,0.014229277,0.010609587,-0.07828416,-0.059576113,-0.08890013,-0.0015409286,-0.104174204,-0.01365514,-0.018473173,0.025509031,0.04930587,-0.0209253,0.05991061,-0.032887794,-0.069548,-0.06314228,0.018632375,0.005003619,-4.2257e-08,0.10500691,-0.03402226,0.017471945,0.0026835036,-0.08106251,0.0072294204,-0.04530861,-0.014317198,0.08987434,-0.03314135,-0.00589223,-0.0009625179,0.019281162,-0.04039679,0.028766776,0.0066246917,-0.021596925,0.09206963,-0.06269012,-0.074444264,-0.08971951,-0.040882703,-0.07854376,-0.005021194,-0.013735082,-0.036526307,0.028311312,0.03418035,0.08202957,-0.12522244,-0.09200211,-0.00991009,-0.0041940417,0.008321262,0.03199402,0.042343307,0.003618796,-0.026457231,0.046170164,-0.0122424625,0.016328987,-0.050481368,-0.060533714,-0.059655502,-0.054046832,-0.019858133,0.038205437,0.06493478,-0.049012884,-0.08251042,0.0066859396,0.025807098,-0.01533208,-0.01556362,-0.058555894,0.02503708,-0.031027498,-0.028079815,-0.05029118,0.017104961,-0.024790892,0.018958563,0.09684417,-0.0008051474 +3.4.21.116,"This enzyme plays a central role in a regulatory checkpoint (the sigmaK checkpoint), which coordinates gene expression during the later stages of spore formation in Bacillus subtilis [1,3]. The enzyme activates proteolytic processing of a sporulation-specific sigma factor, pro-sigmaK, to its mature and active form, sigmaK, by self-cleavage [1,3]. The enzyme is also subject to secondary proteolysis, which presumably inactivates SpoIVB [3]. The enzyme is also essential for the formation of heat-resistant spores. Belongs in peptidase family S55.",384,0.99999994,-0.06892804,-0.072210364,-0.06693652,-0.04309274,0.07485918,0.012275293,-0.037819948,0.08830881,0.03379483,-0.013200837,0.049598686,-0.035310492,0.0766847,0.033016756,-0.08811303,0.034713473,-0.08340605,-0.022913551,-0.00027772615,-0.044844985,0.056374747,-0.008218232,-0.04414612,0.11594558,-0.016481305,-0.071358316,0.046618517,-0.053445723,-0.06267512,-0.013324817,-0.031307086,-0.07370157,0.0583849,-0.053546477,0.11150609,0.041044753,0.02233636,-0.0045668613,0.09201051,-0.0015580119,0.029644957,-0.046485096,-0.045833398,-0.024894513,-0.012192008,0.027950374,-0.004635034,0.097945124,0.018741284,-0.0501112,-0.047910016,-0.046227455,-0.018027613,0.0041291374,0.041505758,0.056746017,-0.040803883,-0.034858078,0.06457069,0.008615362,0.023413612,-0.05681223,0.02761016,-0.033382043,0.06506528,-0.064431354,0.029176015,-0.028680077,-0.011342305,0.026271414,-0.06564982,0.011541982,-0.0137481885,0.10188999,0.06910866,0.06574545,-0.03208528,-0.025306813,-0.017360637,-0.041151278,-0.009691863,-0.016974462,0.03743092,0.08536759,0.00020962305,-0.044300716,0.072639845,-0.0141468635,0.074621096,0.0013589438,0.0077292332,-0.031413753,0.020813083,-0.034444593,-0.07205544,0.03982896,-0.056308236,-0.0091819195,0.05850938,-0.037759807,-0.05252881,-0.052049242,-0.028332701,-0.044256534,-0.029788395,0.0035344095,0.019243507,0.023225976,0.08265336,0.050905738,0.045784395,-0.014153813,0.08749591,-0.050281383,0.0021622924,0.11268593,0.02109804,-0.021152904,-0.013312201,-0.041847773,0.0026767503,0.022729967,0.03300132,0.014582229,-0.00715487,0.02825011,-0.025101874,1.1183767e-33,0.018801479,-0.055115618,0.03732097,0.059619647,-0.011123803,-0.031321537,-0.041157138,-0.078296445,-0.057498034,-0.09874904,-0.07276441,-0.13412,-0.04122021,-0.0029315655,-0.054995097,0.062624045,0.038138423,-0.010396868,-0.06434189,0.05080434,0.036742833,-0.017125752,-0.018827064,-0.03173952,0.08051772,0.029279435,0.037908018,-0.03807893,-0.0267557,0.008959579,-0.027031824,-0.030116336,-0.109157614,0.05708632,0.01636465,-0.016574549,0.01841955,-0.04307366,-0.04290815,0.04451049,-0.058357667,0.059892748,-0.0103469165,-0.0014647525,0.03411608,0.022734674,-0.019219307,0.11083892,0.020417811,0.02896947,0.011990928,0.011317039,0.082960166,-0.0030977072,-0.0056610606,0.024263442,0.023846863,0.0040707593,0.10450683,-0.020732144,0.04014917,0.06849,-0.06267612,0.103370495,0.023859728,0.031331744,-0.054330092,-0.01696458,0.062212422,0.073306784,-0.08945154,0.058970507,0.03769685,0.049457263,-0.056655772,-0.061065722,-0.0305367,-0.037247628,-0.056887522,0.06649298,0.006521372,-0.11311825,-0.05725872,-0.0295219,-0.0849612,-0.06755371,-0.0167816,-0.0394749,-0.05922667,-0.025318284,0.07134667,-0.104647025,-0.045403622,0.100059964,-0.06330232,-1.6078261e-33,0.10597258,-0.07797633,0.10766038,-0.06266772,-0.0769484,0.069228135,0.0072214063,0.025202282,0.01540473,-0.039588038,-0.0027361906,-0.001326555,-0.0055362233,0.00061469147,-0.032498688,0.068302855,0.024348274,0.04416219,-0.020913277,-0.04097147,-0.057913024,0.104853466,0.012820864,0.016162094,0.010468741,0.024439244,-0.01573526,0.19935821,-0.014147502,-0.0012800716,-0.029933717,0.026615242,0.014434021,-0.054475576,-0.03447481,-0.0045046005,0.0063220654,-0.03929414,0.1053186,-0.0776504,-0.02266231,0.063000776,0.012334592,0.037941825,0.010406398,0.13303684,0.042349562,0.024384283,0.05151835,-0.08575199,0.013600987,-0.05321478,0.05854406,0.038314953,0.03986964,-0.06317187,-0.027107945,0.058220446,-0.054718815,0.014828384,-0.029791147,-0.030243795,0.037077483,0.04959443,0.0259143,0.088909015,-0.044835497,0.004937582,0.050192844,-0.017597381,0.021193283,0.010852694,-0.017385513,0.0549118,-0.020581627,0.013886264,-0.1140061,-0.029557945,0.012122703,0.04401559,-0.08328856,-0.038094062,-0.03695996,-0.025110187,0.08026074,-0.016081452,0.008182053,0.04016029,0.018051658,-0.006841295,-0.058684748,-0.049076516,-0.00047756062,0.027090942,0.036565896,-3.955367e-08,0.08211371,-0.053742718,0.013028254,-0.037314776,0.049298458,-0.024420764,-0.04079684,-0.013988544,0.063612394,-0.0730645,-0.047684923,0.02185332,0.02431839,0.016003538,0.062625416,0.001477077,0.0077209384,0.045736328,-0.0453136,-0.011393735,-0.034935687,-0.0660467,-0.0689422,0.0013747412,0.00606601,-0.0072527365,0.06662599,0.053623807,0.008598864,-0.0796794,-0.026588725,-0.011499717,0.0009702868,0.029732086,-0.07503993,0.104717374,-0.08916579,0.029030764,0.08009441,0.057292655,0.07313004,-0.03969582,-0.042116996,-0.03201662,-0.059629112,0.028561926,-0.08221736,-0.0138253765,-0.0011433731,-0.020784706,0.029621055,-0.016926434,-0.014780847,0.043637443,-0.06984356,0.035795037,0.0193171,-0.04237056,0.017268425,-0.043665614,0.04979657,-0.04487219,0.12402269,-0.012659839 +3.4.21.117,"This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at Leu6!Cya7, Tyr16!Leu17, Phe25!Tyr26 and Tyr26!Thr27 [1]. It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures [1,2]. Belongs in peptidase family S1A.",384,1.0,-0.07820039,-0.02766891,-0.033104263,-0.027135624,0.05253203,-0.00015468066,0.035046495,0.09729287,-0.04986881,0.025445975,0.021237828,-0.002319114,-0.058663048,0.083079346,-0.026859578,0.0020282045,-0.061288025,-0.047595408,0.053754464,-0.081776194,0.05421519,0.047293574,-0.050882507,0.020811329,-0.005905906,-0.032165054,0.04392344,0.036731437,-0.003309537,-0.044531837,-0.0049027065,-0.042837515,0.015978383,-0.034459434,0.0020815614,0.019396277,-0.046758194,-0.08442807,0.03082997,0.015419145,0.07805408,0.0040216916,-0.046143807,-0.014641408,0.082009286,-0.031354904,-0.012522089,0.10951409,0.058074843,0.016805377,-0.011053866,-0.06572445,0.05915776,0.03447232,-0.017131992,0.08123595,-0.1415207,-0.040040854,-0.0121251345,0.013476373,0.03477847,0.021782298,0.053566042,0.008086144,0.06629788,-0.09618067,0.08395014,0.005883314,-0.016176164,0.0332071,-0.013853615,-0.01717505,-0.07016412,0.058920894,0.0047142804,0.07597829,-0.0871908,-0.06958977,-0.036968555,-0.0173763,0.03680343,0.024459004,0.13154711,0.060591117,-0.031822495,-0.012805735,0.07723256,-0.09940164,-0.04259826,-0.03996993,0.06882627,0.0142163765,-0.05285971,0.006107495,-0.032947965,0.012116821,0.012262513,0.053984206,0.022927169,0.034845814,-0.056798186,-0.053822175,-0.033612017,-0.04688,-0.077970564,-0.020034676,-0.04051481,0.056033444,0.060387686,0.013276316,0.007228978,-0.012969049,0.042273298,0.002885853,-0.020332927,0.036905922,0.026135545,0.03423822,0.04331477,-0.02390478,0.04716331,0.033268996,0.033602126,0.04547886,-0.037273742,0.022768995,-0.038866457,3.6804633e-33,0.012799115,-0.048713904,-0.004709651,0.010634467,0.017855017,-0.0071907956,-0.06180352,0.0070236987,-0.07134455,-0.0020804377,-0.1363804,0.0076406994,0.0019350398,0.013539239,-0.024307627,0.00074298313,0.0437421,0.020508366,0.093270786,0.008225101,0.038041573,0.107338995,-0.009247796,-0.060957514,-0.013540679,0.09032801,0.016661672,0.008242097,0.06628152,0.006810371,-0.03407642,-0.04521184,-0.04527669,-0.033804297,0.021066483,-0.009812577,0.0006581773,-0.049226888,-0.0037559867,-0.011418273,0.041883722,0.010049732,0.04597203,-0.07572196,0.03035112,-0.0042901556,-0.025107931,0.019866167,-0.059436277,-0.017838176,0.06608897,0.0041732206,0.056883313,-0.01439525,-0.056995187,-0.012745297,-0.059840363,-0.027917411,0.027105458,0.0770007,0.0368158,0.045311995,-0.061161973,0.022015026,0.023001503,-0.037876856,-0.052176923,0.062769935,-0.083837956,0.07311009,-0.030899527,0.03772399,0.09630051,0.009465792,0.037205912,-0.03333705,-0.027797643,0.07540697,-0.040647097,-0.04454658,-0.033654004,0.037935987,-0.023011696,-0.06319623,0.0029453707,-0.04291607,-0.008068574,-0.0073215673,-0.0032788436,0.009351176,-0.007095068,-0.08930702,-0.03848541,0.0558896,-0.015255054,-5.3117934e-33,0.005670083,-0.10321432,0.073880315,-0.056439094,-0.06532955,0.03839472,0.06882392,0.08535975,0.021349523,-0.010911628,0.07858936,-0.021861728,-0.02983176,-0.05965802,0.040968318,0.08046309,-0.06834287,0.037124466,-0.11206753,-0.101066545,-0.073050715,0.07011295,0.009964366,0.046607062,0.020824766,-0.013586127,0.018591626,0.056384034,0.022628622,0.021590848,-0.051457934,-0.06343292,-0.062703535,-0.020910237,-0.09725774,0.007120116,-0.039702207,-0.034503583,0.050225843,-0.0759362,0.033013977,0.01905343,0.0033211247,0.108956404,0.09074315,0.077166274,-0.09266776,-0.0036234315,0.01631509,-0.032662477,-0.0073822,-0.015866043,0.04990796,-0.06637883,0.03468224,0.012609973,0.06357573,0.0038285907,-0.016569214,0.10413543,0.098467566,-0.054789662,-0.0015259335,0.06671932,0.082217045,-0.02269572,-0.06364052,-0.0059875716,0.0008781156,0.033822503,0.09327847,0.0018277279,-0.06566219,0.009599422,-0.014965615,0.047482807,-0.052489962,-0.0088199,-0.051028077,0.010521491,-0.06723751,-0.08987152,-0.030801712,-0.02673624,0.08772094,-0.050080456,0.04869722,0.11164819,-0.01199677,0.030371448,-0.019697078,-0.05640546,0.015367082,-0.0041044606,-0.017206626,-4.6496996e-08,0.09139524,-0.09929589,0.021586748,-0.07979866,-0.068336084,0.04129022,-0.039083876,-0.033827417,0.0947937,-0.07148125,-0.05783032,0.09228399,-0.061712228,0.07118182,-0.011748478,0.057187457,-0.03771291,0.037440307,-0.017204491,-0.064637646,-0.0739016,-0.039365176,-0.09351484,0.034308255,-0.03150182,-0.10654375,0.07290826,0.1342679,-0.049735375,-0.016137714,-0.016199935,0.01636687,0.005398986,0.03048114,0.0049162153,0.03322289,0.00150467,0.0006391908,-0.007455245,0.040336944,0.021351159,-0.08045348,-0.028311515,-0.037735336,0.013449346,-0.026520614,0.035385266,0.026838416,0.008422533,0.028906707,-0.0066162082,-0.04659355,-0.05137421,-0.014930208,-0.07558118,-0.03133262,-0.041800518,-0.013574996,0.04542296,-0.04882249,-0.0018076744,-0.06594449,0.17102566,0.05916885 +3.4.21.118,"The enzyme is activated by removal of an N-terminal prepropeptide [2,4]. The highest amidolytic activity is observed using Boc-Val-Pro-Arg!7-amido-4-methylcoumarin, which is a substrate of alpha-thrombin [2,4]. Substrates lacking basic amino acids in the P1 position are not cleaved [4]. The enzyme degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen [3] and is associated with diseases such as ovarian cancer and Alzheimer's disease [4]. Belongs in peptidase family S1A.",384,1.0,-0.06502495,-0.14042747,-0.08143847,-0.03254772,0.0445061,0.012657211,-0.038587853,0.117441,0.057396196,0.044824585,-0.022616517,0.115650974,-0.053360958,0.03137878,-0.04920521,0.058714975,-0.028938688,-0.008491387,0.039783902,-0.02365962,0.0024856115,0.03152505,-0.029007781,0.07686383,-0.00395946,-0.074876815,0.033607416,-0.0032498126,-0.040168345,0.008099623,-0.009971495,0.02556956,0.040732194,-0.01018865,0.067325525,0.06399009,-0.047780927,-0.029430056,-0.019201744,-0.02803645,0.058299482,-0.0340786,-0.03705724,-0.083353706,0.017698184,-0.08987155,-0.01117267,0.048525553,0.10716214,0.0846072,-0.03529536,-0.034480266,-0.022959191,-0.0032701755,-0.023543434,-0.023175096,-0.09768948,-0.06869586,0.013778494,0.090545096,-0.042601697,-0.034789138,-0.006902751,-0.0075352113,0.0081368815,-0.034832537,0.05829997,-0.044827476,-0.023477158,0.060668606,-0.009170753,-0.044288337,-0.0017783568,0.031070167,0.022195768,-0.006596484,-0.027568107,-0.0125952745,0.02843475,-0.06959735,0.034902915,0.043376006,0.123691685,0.05947056,0.024214812,0.034749985,0.04173966,-0.024284093,0.05982944,-0.007794436,0.03178567,-0.012137696,0.03261352,-0.01582153,-0.026922546,0.00157296,-0.023576364,-0.012380756,0.018049663,0.037930775,0.010303571,0.068529874,-0.002549252,-0.06077516,-0.064610034,0.06171068,-0.02039976,0.08322756,0.050877154,0.015800698,0.028003616,-0.06585165,0.018916637,-0.001816903,-0.03937412,0.053345572,0.061240915,-0.028713113,-0.014748852,-0.0067483825,0.01564141,-0.015412994,0.13217907,0.0761149,-0.052244913,-0.011077162,-0.07774379,2.256333e-33,0.037039787,-0.043742545,0.02367776,0.0034712022,-0.0045975004,-0.038457777,-0.059635196,0.0012080645,0.02389939,-0.04673418,0.01146,-0.051034104,0.01100716,0.0038900396,-0.040224273,-0.045872983,0.02552701,0.006525806,0.0004220762,0.01315933,-0.021216784,0.054158982,-0.022202553,-0.007371829,0.026248125,0.05964076,-0.049051058,0.11104784,0.06292001,0.002665266,-0.026095916,-0.056901556,-0.11071996,-0.044264346,-0.050381657,0.012951348,-0.0018429309,0.034867983,-0.040283024,0.12390277,0.043021653,-0.018819198,-0.040934082,-0.07045249,0.03634429,-0.117956445,0.00804755,0.061292287,-0.07285911,0.013122463,0.012682786,-0.0698897,0.09056202,0.04617125,-0.081600785,-0.027790831,-0.009577973,-0.041610405,0.056462977,0.013000495,0.07505249,-0.0372201,-0.017973322,0.046684857,-0.059603322,-0.07519718,0.0054706,0.03802478,-0.031856734,0.08422561,0.015434642,0.03457561,0.036428034,0.042623077,0.07714129,-0.056553118,-0.012622832,0.053536765,-0.040836815,0.0009417401,-0.006627961,-0.003934,-0.008899667,0.06457731,-0.05234875,-0.027897106,0.07474413,-0.04817522,-0.058663495,0.011073764,0.017785462,-0.06706043,0.0021420175,0.09126861,-0.0372488,-3.0906277e-33,0.035102945,-0.058967903,0.08446418,-0.051763516,-0.10760096,0.065792665,0.0938455,-0.005488159,0.009299599,-0.03664041,0.06806909,-0.04909013,-0.039804198,-0.076624796,0.027626535,0.017722044,-0.039084654,-0.0012680384,-0.09349821,-0.021157796,-0.08486898,0.051137164,0.088379905,-0.001185121,-0.0018863169,0.045252226,0.015688114,0.058298398,0.013917008,0.09185447,-0.070556946,0.03001266,-0.0024389145,-0.0028712007,-0.06956824,0.037298266,-0.010764699,-0.03705947,-0.013565207,-0.031448618,0.05821014,0.07512597,-0.028624551,0.060603958,-0.025607988,0.08249087,-0.022593824,0.027211659,0.011801817,-0.059979077,0.014582056,0.02280459,0.040959235,0.008245349,0.02034345,0.011678731,0.06849793,0.0026820707,-0.042603053,0.054658003,-0.00021965963,-0.028530313,-0.037031353,0.06043042,0.123701155,0.058015298,-0.012338549,0.11891139,-0.015982632,-0.007093603,0.025457729,0.045206886,0.042274006,0.048744116,0.028651977,0.054140173,-0.019517552,-0.050533365,0.031628214,-0.056231685,-0.075824745,-0.07162403,-0.10888496,-0.088085905,-0.047103267,-0.023382574,0.08630659,0.11608657,-0.003183152,-0.0049933884,0.03476849,-0.0632676,0.0053427196,0.01893537,-0.020959578,-5.1265452e-08,0.074485876,-0.10662164,-0.026602274,-0.10693846,0.015568975,0.0015864472,-0.05965017,0.022265509,0.015360054,-0.02894459,-0.069635294,0.07853789,-0.061609592,0.018867224,-0.005091321,0.018957136,-0.041752428,0.06646424,-0.03246842,-0.04020398,-0.066269405,0.00764771,-0.08838332,-0.05426025,0.024496602,-0.06965546,0.0027490228,0.11248122,-0.043484394,-0.03265373,-0.04138382,0.023481205,-0.023578722,-0.031754967,-0.022517767,0.03149763,0.021739176,-0.03387103,-0.049531464,0.023591923,0.03888038,-0.040523287,-0.038487364,-0.058224436,-0.03380693,0.0030462707,0.077945724,0.046449482,-0.012632634,-0.0068370616,-0.038877226,0.0549066,-0.0047955583,-0.09715959,-0.116490185,-0.023742856,-0.006102566,-0.06715916,-0.010433012,-0.079648785,0.038003523,-0.023233289,0.15565264,0.019633085 +3.4.21.119,"The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates [1]. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1beta (pro-IL-1beta) in mouse submandibular gland to form IL-1beta [4]. Belongs in peptidase family S1A.",384,1.0,-0.06481418,-0.088542424,-0.026536124,-0.13425952,0.08318744,-0.06764022,0.009688883,0.07112424,-0.021158816,0.058044337,-0.013684339,0.00044306854,-0.033416644,0.034117818,-0.032665025,0.020214288,-0.08870911,-0.07091192,0.03844369,-0.07450758,0.094658636,-0.017592918,-0.015569463,-0.019491918,0.010407221,-0.12727976,0.047578573,0.040471666,-0.011120509,0.00025565483,-0.02770473,-0.075667836,0.016641846,-0.018443335,0.03657892,0.019478206,-0.06469875,-0.0009411702,0.026017377,0.049014997,0.08176679,-0.027799089,-0.094427295,-0.13838696,0.024796937,-0.0053042285,-0.005445802,0.038782414,0.015536964,0.16011862,0.05211669,-0.04540614,0.058594715,0.032197896,-0.02438252,-0.01769226,-0.057756405,-0.0018775635,0.021544216,0.08453143,-0.053789765,0.020301478,0.004580076,-0.017628029,0.067027286,-0.07854983,-0.0044780364,-0.009343436,-0.063083075,-0.053487446,0.038033616,-0.050471734,-0.0770337,0.05627658,0.025351953,0.019829722,-0.035900097,-0.09142515,-0.0032729646,-0.041528765,0.020296205,0.059907436,0.079337716,0.005168593,0.020811826,0.011934776,0.012547093,0.027751844,-0.008424464,-0.05968998,0.035670448,-0.044818036,0.02848895,-0.0016147335,0.043809213,0.09918233,-0.055829998,-0.048742265,0.01883117,0.038493197,-0.083309524,0.035932377,0.01269684,-0.08589608,-0.0102305235,0.05876432,-0.0042080074,0.097614795,0.0078027477,0.006547811,0.047652356,-0.005707547,0.05252279,0.020954689,0.021481985,0.050706573,-0.026799807,-0.0130012,-0.006922623,-0.044030737,0.012237394,0.01765861,0.013281198,0.06803856,-0.010951149,0.08199866,-0.04326234,4.202469e-33,0.014629053,-0.050009094,0.024906337,-0.029308282,0.0036105998,0.055840205,0.026918193,0.0465397,0.008048039,-0.07410618,-0.08029936,-0.11918815,-0.009243836,-0.02083207,-0.018027032,-0.028126901,0.07155646,-0.008699887,0.06395806,-0.014430578,-0.038167305,0.02338103,-0.028505359,-0.04360482,0.043479085,0.027842937,0.0031449937,0.013208104,0.05308326,-0.010945393,-0.06381321,0.005527857,-0.07326327,0.03323277,-0.043168742,-0.07040785,0.006541577,-0.05286383,-0.03067144,0.022105757,0.017574936,-0.022495916,-0.029988687,-0.068343595,0.017127637,-0.07672415,-0.10560499,-0.023806203,-0.052243765,0.07691176,0.050720613,0.013401315,0.024606224,-0.039879028,-0.06042039,-0.023446064,-0.04136351,-0.06190543,0.07732779,0.066581056,0.015455026,0.03764248,0.030012159,0.08400616,0.0007562421,0.03130544,-0.081826076,-0.04976925,-0.07716489,0.04660903,-0.036107674,-0.025135519,0.04604254,-0.048543192,0.036343914,-0.027216181,-0.0092397025,0.11675564,-0.021815864,-0.038457565,-0.059674874,0.06840144,-0.0213312,0.09747224,-0.036157746,-0.0789019,0.015522918,-0.09675964,0.032177523,-0.016612493,0.08191002,-0.015173596,-0.1003678,0.06411648,-0.051953364,-6.207767e-33,0.039946117,-0.06108081,0.10347281,-0.083917975,-0.10377746,0.08982523,0.06612813,-0.022851083,-0.02050823,0.039460298,0.005261433,-0.0056782677,-0.0682182,-0.06876985,0.022406388,-0.018430522,0.009748125,0.036367968,-0.074392445,0.029675556,0.036914475,0.097429685,0.03872014,0.014521731,0.04216959,-0.046085212,0.02454316,0.036763553,0.06326136,0.037484325,-0.063429035,0.03354998,-0.06659288,-0.06632115,0.027964683,0.004053877,0.00541365,-0.035245802,0.0034602226,-0.0417408,-0.04010345,0.002097301,-0.01913619,0.048170917,0.07073597,0.02186244,0.00406068,-0.034937218,0.028298454,-0.099695265,-0.0631032,-0.015966916,0.078663476,-0.06631285,0.028147379,-0.047735225,0.055439014,-0.016643515,-0.03889049,-0.004053324,0.008428756,-0.023967905,-0.03836508,0.042568088,0.04268202,-0.0026936727,0.0016006241,-0.044501577,0.03717915,0.018166587,0.16492331,0.015716527,0.052328568,0.01597778,-0.0322241,0.006393296,0.01887683,-0.026358215,0.03250409,-0.07069293,0.0036110845,-0.010573516,-0.04521136,-0.045143053,-0.034023937,-0.04799448,0.03382148,0.10893978,0.0021947804,0.03319717,-0.014916583,0.011652832,-0.04035342,0.042292092,0.027448494,-4.3789466e-08,0.08546506,-0.02938025,0.060998805,-0.07257808,-0.044536315,-0.044130404,-0.018602522,-0.0066130753,0.05444593,-0.05673858,-0.044418376,0.09519079,0.028222246,-0.021857642,0.025380243,0.07663645,0.025587352,0.056135193,-0.020184947,0.025121516,-0.050187975,-0.01297302,-0.12356783,-0.005782601,0.008495159,-0.097514085,0.004865183,0.121702015,-0.03641445,-0.009448232,-0.023266008,0.03019583,0.01469831,-7.093253e-06,0.09748503,-0.007715419,-0.021917176,0.021440525,0.012353439,-0.0699775,-0.01778147,-0.036283016,0.012512039,-0.04432732,-0.00044623946,0.040546067,0.017409597,0.008031568,0.03919677,0.010694026,-0.038988605,0.020016164,0.0062448303,-0.08160637,-0.026152926,0.029711127,-0.04434699,-0.077007495,0.071723536,-0.05287617,0.08319487,0.09195355,0.1171344,0.03848973 +1.4.3.20,"Differs from EC 1.4.3.13, protein-lysine 6-oxidase, by using free L-lysine rather than the protein-bound form. N2-Acetyl-L-lysine is also a substrate, but N6-acetyl-L-lysine, which has an acetyl group at position 6, is not a substrate. Also acts on L-ornithine, D-lysine and 4-hydroxy-L-lysine, but more slowly. The amines cadaverine and putrescine are not substrates [2].",384,0.99999994,-0.009251107,-0.1459305,-0.037121627,-0.05205412,0.12932462,0.04879097,-0.061568066,0.02635977,0.012789314,-0.029562894,0.06816361,0.022371983,-0.042788863,0.077459246,0.0092639,0.034643702,-0.051265582,-0.065509655,-0.03714618,0.025376188,0.06321275,0.046958167,-0.020700749,-0.045564406,0.02701779,-0.07169986,0.029705292,0.005036186,0.06219763,-0.05529468,-0.004335502,-0.03189426,-0.024674682,-0.048859566,0.027920472,0.046677344,0.020479187,-0.053603,0.016900415,0.0038785215,0.013982589,-0.05297534,-0.08222669,-0.024802383,0.037353303,-0.009640091,0.021868857,0.0021225663,-0.014539503,0.01751459,0.027404528,-0.06478715,-0.03052182,0.024511902,-0.052072216,0.009579787,-0.14849763,0.008068467,-0.028447978,0.08101815,0.0133100115,0.07753031,0.032836974,0.0048890044,0.02608323,-0.06931787,0.046068355,-0.07935124,0.015417928,-0.053565122,-0.048331026,-0.12944748,0.054006875,0.053993315,0.030159213,-0.0020204473,-0.008022111,-0.028184095,-0.019448593,-0.08384955,-0.046726048,-0.024980836,-0.068124674,0.13658614,0.008653442,-0.036306687,-0.031634916,-0.00773053,0.008657859,-0.03335519,0.06106258,-0.0047169584,-0.027075477,0.001182779,-0.042579513,-0.07094513,0.046055794,0.09631584,-0.018932527,0.015275939,0.0030771731,0.08938194,-0.060560785,-0.0016218486,-0.017661273,-0.011295553,0.020959225,0.059169132,-0.0058253636,-0.022737127,0.026836986,0.04994694,0.025088785,0.020151626,-0.017517691,0.039951507,-0.05382365,-0.08830833,0.044262536,-0.033540707,0.020169355,0.046223685,0.0978396,0.09451492,-0.03167791,0.07062631,-0.012875051,7.1742284e-34,0.055678032,0.0027269286,0.031459805,-0.03785653,0.024096671,-0.0009363912,-0.069432184,0.04518052,0.053649068,0.0040364424,-0.07846817,-0.05676016,0.06668131,0.080481425,0.036344983,-0.025328618,-0.031048337,-0.035099342,0.07509208,0.090963796,-0.029132413,0.037597228,-0.016287262,0.025443941,0.030255182,-0.015323326,-0.003491645,-1.4468229e-05,-0.017577376,0.007471741,-0.081022665,-0.07955348,0.02383623,-0.037159264,-0.035407986,0.00799672,-0.028343514,-0.034527164,-0.0025040486,-0.050477102,0.07434778,0.05776728,0.005265677,-0.030155014,0.038448207,-0.026654445,-0.050097954,0.09860841,-0.059919745,0.01821776,0.03782796,-0.09480731,0.053804945,-0.05799119,-0.032351043,-0.012584885,-0.095159866,0.05733951,0.049785092,0.07705167,0.05529774,0.07594978,0.0007582122,0.06717787,0.022861354,0.04341075,-0.06505722,-0.044637788,-0.0318325,0.008743916,-0.07554027,0.06437336,0.08170279,0.051021468,0.055094335,-0.08950132,-0.112130724,0.08015799,0.065875925,0.017639145,0.07532281,0.0011041554,-0.0708445,-0.057809338,-0.06296645,-0.03276293,0.052482065,-0.0423666,0.026370615,0.0051463456,0.033589754,-0.07036175,-0.010597951,0.0018471071,-0.0105896555,-3.370889e-33,0.032052115,-0.08994585,0.033186145,-0.049347192,0.008501932,0.019757926,0.057861246,-0.0017191975,0.022100765,-0.048999447,0.060296416,0.0019313111,-0.032032177,-0.04480123,0.04712094,-0.014294071,-0.11899957,0.0033233906,0.072612435,0.030935127,-0.021955607,0.020205596,-0.015283497,0.052421443,0.084472254,0.020197151,-0.04988498,0.06284621,0.056463376,0.019694747,-0.0010557123,0.0036590083,0.0030441564,-0.053711616,-0.035946593,0.04399336,-0.020524941,-0.025435934,-0.025148137,-0.06696862,0.047319856,0.045589782,-0.031306297,0.07317231,-0.022616042,0.061463993,-0.056193616,-0.065906845,-0.025592044,-0.053882927,0.011661245,-0.07081068,-0.0204007,-0.009063971,0.032688916,0.062034726,-0.0110084545,0.012356116,-0.011496537,-0.009696796,-0.017798694,-0.018850459,-0.056936543,-0.020777216,0.05368931,0.012954924,-0.05223581,0.08066915,0.010527052,-0.01628508,0.059221152,-0.040541776,0.046833243,-0.021821365,-0.041157212,-0.025650902,-0.048576526,-0.07509089,-0.030568847,-0.03508845,-0.036221236,-0.021978434,-0.04944867,0.009320449,0.010809187,0.03727361,0.04667633,0.090774104,-0.02154704,0.048889503,0.031092705,-0.06121366,-0.06502113,0.059465174,0.05597136,-4.607156e-08,0.15374455,-0.09984476,0.0612111,-0.06406676,-0.071902804,0.0039645825,0.04627004,0.016685713,0.01094534,-0.014950799,0.015008573,0.10082594,-0.031581674,-0.046530046,0.0028600208,0.024579046,-0.078664236,0.06353721,-0.028236441,0.0018092613,-0.04055468,-0.0005558904,-0.046769205,-0.021448145,0.015539646,-0.065799564,-0.0123970155,0.07215027,0.0009297891,-0.09803934,0.02361337,0.00080086355,0.032133456,-0.049574427,-0.0075018858,-0.0045309584,-0.015512699,-0.043251958,0.020674631,0.023001526,-0.05399974,-0.06932475,-0.083143935,-0.004746952,0.12262008,-0.0072400616,-0.017359192,0.0040563853,-0.012147935,-0.0017120187,-0.01115298,-0.04953361,0.027281381,-0.09245965,-0.050738145,0.022441022,-0.09240435,-0.039726622,0.067456014,-0.051231112,-0.008678245,0.057743482,0.22279587,0.0023451443 +3.4.21.113,"The polyprotein of noncytopathogenic pestiviruses is cleaved co- and post-translationally into at least 11 proteins (Npro, C, Erns, E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B) [2]. The genomes of cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80) [2]. This enzyme, which resides in the N-terminal region of NS3 (nonstructural protein 3), is essential for generation of its own C-terminus and for processing of the downstream cleavage sites, leading to the release of the pestivirus nonstructural proteins NS4A, NS4B, NS5A and NS5B [1,2]. Belongs in peptidase family S31.",384,0.99999994,-0.072009295,-0.064847566,-0.08871933,-0.06382686,0.06922765,0.058523726,-0.0076875854,-0.014441306,-0.01623226,0.0130221965,0.017468814,-0.015076524,0.026403783,0.06285935,-0.04021944,0.010204869,-0.08223417,-0.025893968,-0.0067823157,-0.15110222,0.05242446,0.028422788,0.031592373,-0.020810464,-0.027023979,0.033514105,-0.032240946,0.019604377,0.05405279,-0.055621136,-0.020732267,-0.03377402,-0.016114468,-0.0051461984,0.07481939,0.034147773,-0.082212575,0.028885832,-0.039705776,-0.047407184,0.15490928,0.094832815,0.0039314697,0.033869743,0.018511843,0.03779838,-0.041387603,0.014767178,0.05048147,-0.1168781,0.023769539,-0.06638282,-0.02692838,0.05847409,-0.020492464,-0.007268089,-0.028529424,-0.09417146,0.047846198,-0.0151785035,-0.008887685,0.04879912,0.067606695,-0.036245327,0.09689196,-0.09376544,0.0055557652,0.024930237,0.0049330005,0.07117672,-0.053936653,-0.041330148,-0.08351306,0.086822584,0.009171832,0.05518493,0.087872624,-0.0005520348,-0.08171657,-0.03034825,-0.038900234,0.00606969,0.108093016,0.10229564,-0.0037642354,-0.071840316,-0.03155357,0.021830864,-0.0026333753,0.04906203,0.009757341,-0.012709754,0.032078736,-0.0017462469,0.004490917,0.048883773,0.048489112,-0.057740476,0.01938349,0.026082985,9.781628e-05,-0.019530356,-0.020704364,-0.012900798,-0.052596055,-0.014229174,-0.032343734,0.03417318,0.024104113,0.077097,-0.04081557,0.034044053,-0.019308837,-0.071174085,0.0059866793,-0.00784137,-0.049095426,-0.005106844,0.08437341,-0.008964329,0.0037981914,0.025272258,-0.018414944,0.08753498,-0.041127257,-0.0016646346,-0.12775561,1.4102447e-33,-0.050997924,-0.033731084,0.020933056,0.047551908,-0.041611485,-0.009051996,0.036972374,0.056896873,-0.008082124,-0.04188215,-0.08545556,-0.057374567,0.099745415,-0.040523484,-0.008371564,-0.0058716014,0.010227953,0.02630395,-0.0010866066,0.05944574,0.020525845,-0.0025455921,-0.023377193,-0.009628243,0.09042689,0.006594958,-0.043457497,-0.06877489,0.0517516,-0.044424832,-0.03493079,0.011741285,-0.06356994,0.025953945,0.0002660353,-0.04666438,0.0044711344,-0.121123396,-0.024481798,0.060100164,-0.015541806,-0.004945389,-0.02257019,-0.036597513,0.07542653,-0.072081186,-0.08708072,0.04226989,-0.060171776,0.017640786,0.10483293,0.017931247,0.100329176,0.007336583,-0.10114435,0.0030018708,0.0056991274,-0.04147279,0.017309103,-0.06025765,0.036681548,0.00051554776,-0.03986341,-0.0019039608,0.04753949,0.035404626,-0.023703495,0.010479268,-0.041427013,0.0776089,-0.08181916,0.015876912,0.03757743,0.04206033,0.042011585,-0.0066325627,-0.10695678,-0.0064291884,-0.0044835983,0.070731334,-0.007697164,2.0805875e-05,0.045267608,0.0127120195,0.002648316,-0.105496146,0.010994918,-0.029977255,0.01325189,0.05279824,0.08416331,-0.042860948,-0.011946161,0.09781701,-0.08304716,-3.6645015e-33,0.015506795,-0.042933267,-0.0056040813,-0.0723761,-0.101186216,0.07892698,0.007248692,-0.00842566,-0.0071650366,-0.044784095,0.03147343,-0.014415754,0.06874866,-0.070295304,-0.011130262,-0.006563185,-0.043180168,0.12508278,0.0035665182,0.029377168,0.027716517,0.06030233,-0.051257044,0.01777053,-0.035770826,-0.049072567,0.025052058,0.09936184,-0.021556824,0.018867696,-0.02112043,0.04005266,-0.018730195,0.04951074,-0.02097338,0.019503545,-0.036625355,-0.06404944,0.01608959,0.03159636,0.0050681597,0.15055013,0.05384708,0.08456055,-0.009261309,0.11579348,0.023361968,0.134701,0.07238455,0.008632286,0.02674799,-0.08189396,-0.0018805503,0.059495997,-0.008593877,0.018892987,0.015399679,-0.017592253,0.07666,-0.07091481,0.0027865402,-0.0537647,-0.0149026355,0.051173303,0.023304041,0.042245194,-0.04363399,0.0995732,-0.0020978216,-0.05366847,-0.0191332,0.0026187417,0.03495355,-0.037796672,-0.01069962,0.02044905,0.029827263,-0.011175412,0.00608179,-0.10855516,-0.007660586,0.02657403,0.008557874,-0.0643515,0.08575202,-0.001758875,0.059249885,0.0678135,0.03377548,-0.034109857,-0.010591281,0.025324553,0.03306382,0.059030127,0.027690306,-4.930297e-08,0.09992459,-0.06281643,-0.019950902,-0.019991318,-0.027445659,-0.00379978,-0.04691633,-0.05482168,0.05860421,-0.0014640414,0.03822543,-0.067441985,-0.018812235,-0.035031952,0.042743385,0.04674687,-0.021666542,0.050265934,-0.008964888,-0.03517872,-0.12217014,0.050781567,-0.115980655,-0.0126294475,0.017747812,-0.04548895,0.03237682,-0.0034283008,0.009731626,-0.11524445,-0.04478188,0.027520735,-0.0265932,-0.019238885,-0.055298537,0.03994913,0.03536666,-0.013434281,0.06920282,-0.0075779143,0.03911744,-0.050491996,-0.04798818,-0.06609754,-0.0032065806,-0.03338848,-0.066775724,0.0054388014,-0.01703132,-0.06737602,0.022599583,0.010152108,-0.00017945365,-0.05376991,-0.06898095,0.012094772,-0.029359883,-0.09110549,0.046662573,-0.03899892,0.0041251294,-0.050866105,0.097222984,0.06741648 +1.1.1.291,"NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).",384,0.99999994,-0.016522687,0.02434921,-0.024590196,-0.07293064,-0.0028980551,0.08276043,-0.09039805,-0.024330365,0.0112613365,0.01659527,-0.005005807,-0.077077225,-0.060351133,-0.012227798,0.0018943395,-0.022678012,-0.06255537,-0.012216092,0.0073926053,-0.02514823,0.05995832,0.04469461,0.019370256,-0.036037207,0.00962621,0.00458526,0.038020425,-0.040206585,-0.07666651,-0.08647061,-0.06134873,-0.016577827,-0.016243348,-0.078320004,0.0324917,0.016754115,-0.06533218,-0.055067882,0.03964618,0.02016964,0.07219233,0.033955865,-0.0922951,-0.021203635,-0.07172908,0.006800814,0.061210807,-0.008989716,0.030524882,-0.045703698,-0.07133944,-0.0112955915,0.021714587,-0.019941505,0.015119227,-0.06963116,0.016939342,0.006239809,0.0007321121,-0.08303884,0.042148266,-0.03786286,0.0418576,-0.011255199,0.03791232,-0.05963419,0.0712053,-0.046920195,-0.015507585,-0.0050625517,-0.1649095,-0.05192138,-0.01347608,0.03999109,-0.03931014,0.04529117,0.0022033625,0.015068016,0.041535445,0.01328641,-0.018976795,-0.0052636727,-0.03125967,0.0332704,0.030294228,-0.028466465,0.0025941457,-0.0038990728,0.053476274,0.012602216,0.02749592,-0.037865687,0.007933683,0.014393076,-0.13677621,0.02202345,0.019151844,0.04990999,0.038500812,-0.078771,0.005958372,0.12915052,0.006456663,-0.05326709,-0.03285329,-0.025774267,0.036570255,0.13269237,0.008195454,0.0026687696,0.04058846,-0.057982303,0.01679009,-0.044656944,0.03660201,0.08245071,0.015692426,-0.0402642,-0.06719967,-0.0019461792,0.03056652,-0.032189,0.12829801,0.0642749,-0.023518236,0.0037556489,-0.14810173,3.615584e-33,0.11073468,-0.0033538367,-0.013486627,0.0012500032,0.10432703,0.044488065,-0.10191602,0.047321618,-0.033093307,-0.057587437,-0.074615404,-0.064388216,0.02624539,-0.020421933,-0.039895225,0.038039107,-0.07957485,-0.038007878,0.014703124,0.0054488806,0.049844984,0.03379722,0.021746442,0.025266757,-0.0062238947,0.05816753,-0.031982046,0.021785082,-0.01900011,-0.015608803,0.0617259,-0.12715806,-0.14418353,-0.040378682,0.050062113,0.013646318,0.0136430515,-0.0007597346,0.0028430978,0.035730124,-0.008523073,0.061913505,0.053235743,-0.045102663,0.052231103,-0.026503962,-0.038690496,0.079178646,0.08663538,0.0387827,-0.015415724,-0.047434594,0.16701701,-0.10737569,-0.054683372,0.055907182,0.0031201977,0.046708334,-0.006763621,0.09785158,0.04912053,0.078487076,-0.013004218,0.08286892,-0.030049382,0.050034843,-0.023225535,-0.02974937,0.06250869,0.0030988737,-0.063885026,-0.0025618884,0.12389516,0.022100605,0.04948843,-0.10397727,-0.04669685,-0.03626018,-0.031243686,0.063179635,-0.050969455,-0.037352297,-0.030479573,-0.005239395,0.050304227,0.002691975,0.0011557163,0.0026259944,0.04392428,0.082918175,0.026769603,0.023648616,-0.020570725,-0.006388927,0.03564038,-4.8920273e-33,0.085898824,-0.047633838,0.08139261,-0.11580677,-0.02192909,0.08161642,0.074531294,-0.012800705,-0.019295525,-0.069700144,0.07628238,0.0348327,0.013434484,-0.010062255,-0.019149452,-0.0092762485,-0.046159446,0.08215708,-0.015498393,-0.025629831,0.004823073,0.08615235,-0.012335334,-0.023996614,0.04401338,-0.0075772307,0.009202438,0.06673111,0.025475757,-0.036635086,0.010113561,0.073356815,-0.060775317,-0.053766128,-0.06514959,0.013000461,-0.0934314,-0.010381096,0.015445093,0.025417244,0.042511534,-0.000240104,-0.04045167,-0.02935856,0.053475555,0.019401247,-0.094144076,0.001972566,-0.015060058,0.0040607406,0.029287014,-0.029309278,-0.057911653,0.04362832,0.0537917,0.05662217,-0.0018328783,0.06470002,0.03506375,0.013862345,-0.041852698,-0.03138307,0.07336902,0.017750947,0.078732066,0.037242558,0.022595098,0.07150824,0.06392755,-0.03936647,0.08622495,-0.019055283,0.0040156506,0.018644424,0.018089399,0.008190472,-0.0914113,0.0237667,-0.026615974,-0.03420109,0.020059777,-0.013331702,-0.025367923,-0.033198405,0.008028157,0.019935101,0.024506062,0.07758408,-0.03240721,0.015092525,-0.01163,-0.034309,-0.01049365,0.045086604,-0.027325714,-4.8110856e-08,0.0036448836,-0.0102069955,0.020528315,0.001211494,0.05389544,0.01857546,-0.04271512,0.011929041,0.043945078,-0.022402234,0.026748504,0.079098016,0.029885827,0.060157474,0.039193645,0.012129465,-0.044578772,0.03328752,-0.012907745,0.008576513,-0.112900354,-0.0029881136,-0.10910386,0.067125835,0.040585786,-0.027039109,-0.014354691,-0.021055091,0.057202518,-0.0917491,0.013329072,-0.010132041,0.08566303,-0.020083452,-0.106749795,-0.032791976,-0.084647566,-0.03331705,-0.05884576,0.049893674,-0.0056723203,-0.101679094,-0.041552,-0.007007833,0.027193805,0.05972489,0.0023196936,0.03243141,-0.09041262,-0.043609407,0.018648814,0.04160885,0.043012325,-0.06860544,-0.09201556,0.032087542,-0.006400519,-0.049906857,0.01977757,-0.007382055,0.08232628,-0.03166162,0.08767068,-0.0461028 +1.1.99.31,"This enzyme is a member of the FMN-dependent alpha-hydroxy-acid oxidase/dehydrogenase family [1]. While all enzymes of this family oxidize the (S)-enantiomer of an alpha-hydroxy acid to an alpha-oxo acid, the ultimate oxidant (oxygen, intramolecular heme or some other acceptor) depends on the particular enzyme. This enzyme transfers the electron pair from FMNH2 to a component of the electron transport chain, most probably ubiquinone [1,2]. It is part of a metabolic pathway in Pseudomonads that allows these organisms to utilize mandelic acid, derivatized from the common soil metabolite amygdalin, as the sole source of carbon and energy [2]. The enzyme has a large active-site pocket and preferentially binds substrates with longer sidechains, e.g. 2-hydroxyoctanoate rather than 2-hydroxybutyrate [1]. It also prefers substrates that, like (S)-mandelate, have beta unsaturation, e.g. (indol-3-yl)glycolate compared with (indol-3-yl)lactate [1]. Esters of mandelate, such as methyl (S)-mandelate, are also substrates [3].",384,1.0,-0.007881329,-0.04328729,-0.09708781,0.026828362,0.10984743,0.031806596,-0.05731988,0.022551415,-0.0010279674,-0.067190625,0.010345021,-0.03411156,-0.08306982,0.06315505,-0.06641249,0.052787554,-0.06968565,-0.06403237,-0.019167786,0.053455092,0.05527084,0.05173769,-0.06391426,0.011742065,-0.0312734,-0.00784085,0.023198228,0.0061971135,-0.032935314,-0.047694605,0.031239878,-0.05297998,0.04595916,0.0031652688,-0.015753312,0.097152986,-0.0058485265,-0.043762494,0.01231071,0.03739593,0.0073742648,-0.042640805,0.005651065,-0.009287649,-0.019436827,-0.017278839,0.016898284,0.015480951,0.056794815,0.0018500116,-0.02229868,-0.01027076,0.014384537,0.119015925,0.024544964,0.10397299,0.030901194,0.032181095,-0.0987847,0.013359164,-0.041985832,0.033564784,8.585576e-05,0.012794898,0.036558308,-0.036704946,-0.019560698,-0.0657941,-0.026342038,-0.031297762,-0.028431268,-0.066072255,-0.022647211,-0.02927629,-0.021268878,0.065578714,-0.051153515,0.01205073,0.06143117,-0.08709003,0.023115192,0.008147176,0.07013594,0.08098571,0.035337765,-0.073505335,-0.012199153,-0.018665766,0.06682771,0.07390816,-0.0012995008,-0.008961432,-0.02816516,-0.027119761,0.018073305,0.046094246,0.1025425,0.0773712,-0.024733514,-0.018577388,0.02558016,0.06812235,-0.062157426,-0.098098025,-0.045322586,0.04182322,0.038845457,0.07630154,0.088123865,0.018462535,-0.03346348,0.03334487,0.027880335,-0.018843243,0.010986883,0.023823941,0.03050265,-0.045026008,-0.06612321,-0.00691297,-0.03084326,0.0034303518,0.057628557,0.049407393,0.030855,-0.026521577,-0.15980282,1.812546e-33,0.041979402,0.034063812,-0.040297184,-0.049765777,-0.027866919,-0.04406185,-0.11439062,-0.004209729,-0.042088527,-0.0047021275,-0.05315479,0.0056655644,0.00012661297,0.055808023,-0.00016693558,-0.03957273,-0.056508586,-0.043176807,0.0888006,0.044727255,0.05111446,-0.0045247315,-0.039501533,-0.053748764,0.013418635,0.023899827,0.0032774922,0.052609134,-0.037514888,0.005677021,0.019491382,-0.055521403,-0.11447096,-0.00070058776,0.01058577,-0.037944436,-0.09217151,-0.0035237873,-0.025428267,0.046221737,0.09624103,0.05201695,-0.021221649,-0.049427364,0.105952114,-0.045576993,-0.012021816,0.12480052,0.046923533,0.063237086,0.01326771,-0.054764576,0.07789116,-0.039261088,-0.06002288,-0.04034761,0.0023703636,0.02859202,0.052608833,0.06404218,-0.014337944,0.044192024,-0.03356566,0.06091492,0.034422703,-0.010889068,-0.032254525,-0.01820817,-0.0052144593,0.028389534,-0.0076373736,-0.0039222385,0.11003575,0.007846685,-0.03275109,-0.059906952,-0.0731458,0.00924525,0.05432885,-0.016183708,-0.045213867,-0.069524586,-0.022061348,-0.053325325,-0.06965008,-0.0017454578,0.016811818,-0.014519308,-0.08510761,0.0065596565,0.12216977,-0.082810886,-0.018056704,-0.007091211,0.07149246,-2.6835032e-33,0.07041296,-0.078357264,0.008671142,-0.07368248,0.027877908,0.049755417,0.029435005,0.022000115,0.036110815,0.005141538,0.051757496,0.057450645,0.042889196,-0.04165559,0.036047325,-0.013648608,-0.02488613,0.017117564,0.04510758,-0.04133573,0.061022088,0.08532454,-0.036262266,0.030062446,0.03524808,0.045886345,-0.051358186,0.10317562,0.038030352,0.09348794,-0.029119918,0.09590605,-0.05597227,-0.06382616,0.009643219,0.08292891,-0.100186214,0.018817503,0.04115178,0.039488997,0.043224957,0.03372752,0.02027757,0.023162983,0.040018603,0.17292354,-0.13674979,-0.006500319,0.0051543443,-0.016878162,0.011385597,0.028122745,-0.08197033,0.021676717,0.013384093,0.03784068,-0.041081633,-0.00401892,-0.013891167,-0.04931051,-0.04061534,0.012604927,-0.020329464,-0.021338215,-0.08642549,0.029782748,0.03339898,0.03815045,-0.0006293766,0.031173943,0.033201236,-0.03308057,0.058406096,0.049941473,-0.032197185,0.039637312,0.0021907557,-0.015413018,0.0052704457,-0.017287405,0.009488119,0.004594031,-0.02271828,-0.07683837,0.030054161,-0.058708996,-0.0009456922,0.1092403,-0.03604408,0.017729394,0.044321224,-0.008807188,-0.065498695,-0.01554917,0.03173684,-5.164285e-08,0.00502876,-0.11370234,0.09317798,-0.04908456,0.06505246,-0.011605242,0.049290165,0.056652617,0.06530255,-0.02293861,0.0055418517,0.09749224,-0.01797338,-0.011632909,0.058005452,-0.031046622,0.0034616257,0.020512227,-0.05380173,-0.065969124,-0.08553702,-0.04029338,-0.12853107,-0.014926311,0.023541419,-0.08388711,0.027496003,0.0047383746,-0.017452024,-0.045961585,0.012219494,0.073217966,-0.019055407,-0.0445843,-0.11894663,0.03459258,-0.003881986,-0.03497922,-0.025044046,-0.013236631,-0.00970879,-0.080163665,-0.044548392,-0.011881609,0.052231986,0.028610082,-0.020578993,0.049474455,0.025702989,-0.033554126,0.043792244,-0.06525726,0.0031782237,-0.07205907,-0.06876209,0.04262327,-0.06343113,-0.035219472,0.008986233,-0.062064566,-0.0050482512,0.018720558,0.1576984,-0.04202305 +1.3.3.12,"A flavoprotein. Acts on the 1,4-lactones of L-galactonic, D-altronic, L-fuconic, D-arabinic and D-threonic acids; not identical with EC 1.1.3.8 L-gulonolactone oxidase. (cf. EC 1.3.2.3 galactonolactone dehydrogenase).",384,1.0,-0.04967538,-0.11228581,-0.049648955,-0.011926391,0.084665984,0.02531374,-0.06265027,0.03586247,0.044995435,-0.07654789,0.037837368,-0.058940273,-0.094413035,-0.019003382,-0.062166117,0.025577318,-0.07105564,0.02322414,-0.079276636,0.02837808,0.071986645,0.011654656,0.039451074,0.034492593,0.07186739,-0.007324599,-0.01251763,0.009662503,-0.05051394,-0.09203823,0.08387344,0.0031674376,0.044380795,0.052443396,-0.043775138,0.07499038,-0.0023955829,-0.04657866,0.0517399,0.020395802,0.031386424,-0.09177547,0.090447426,-0.0020150319,0.012775306,-0.0048090084,-0.015929904,0.10124994,-0.027178092,0.059819374,-0.025831185,-0.104072966,-0.09017544,-0.0029680307,-0.017256754,0.08677197,-0.0054278537,-0.022154383,-0.031138295,0.030082574,0.04282538,0.011251682,0.060492296,0.03581048,-0.016413765,-0.04944792,0.07367919,-0.075164594,0.040306423,-0.023054268,0.0406777,-0.043768503,-0.029949209,0.042582087,0.00026235823,0.13051744,-0.05422285,-0.018426616,0.010390735,-0.07061961,0.0790011,0.010750585,0.039428968,0.039273914,0.057106696,-0.10633283,-0.049606588,-0.003171784,0.030560827,0.0282069,0.027815862,0.0036425758,0.025927491,0.03331408,-0.02217269,0.0793896,0.057970304,-0.025090748,-0.08880748,-0.012490017,-0.045144707,-0.04269347,-0.025611462,0.030277433,-0.0038145264,0.02309502,-0.0546237,0.001685067,-0.07065432,-0.062709875,-0.0072938288,-0.08505225,0.06796074,-0.019322034,0.029499216,0.043171365,0.013375123,-0.046777833,-0.069073826,-0.014877324,-0.030130962,0.05609344,0.039631665,0.057606608,0.0063404874,-0.004759698,-0.06587263,2.2360652e-33,0.13933977,0.012870686,0.0071459403,-0.01489036,0.0378137,-0.00784961,-0.078927726,-0.0067635435,-0.034811545,0.02876999,-0.09798055,0.052984547,0.07149767,0.012968665,0.016362045,0.06953472,0.012198007,-0.032453522,0.016726607,-0.06832495,-0.029084984,0.03389533,-0.040740475,0.035157822,-0.0103825675,0.022202091,-0.002496204,-0.032019716,0.06013083,0.026624119,-0.064767115,-0.10473317,-0.077352576,0.038801067,0.0033029888,0.056420933,-0.09777919,-0.092192344,-0.078586206,0.025819642,-0.0006775439,0.0013940347,-0.08841952,-0.047229834,0.034523766,-0.01290823,-0.031181507,0.0972955,0.037505638,0.042494014,0.05864593,-0.050126262,0.061609164,0.067871496,-0.036473397,0.041278988,-0.07247162,0.0913601,0.042222098,0.015763888,0.050348356,0.026596855,0.02745716,0.023438103,-0.0037684795,0.049209908,-0.05516727,-0.04978345,-0.015158722,0.022253659,0.059212837,-0.055676907,0.09252421,0.020174345,0.03145892,0.022750912,-0.07361615,-0.06091172,-0.049736984,0.040077463,-0.057989527,-0.011672218,-0.019386988,-0.0054811137,-0.051538054,0.07346324,0.017278057,-0.020944962,0.036664367,-0.019071018,-0.050590675,-0.028173203,0.028807614,-0.066783786,0.0292185,-1.3634396e-33,0.004697982,-0.08176639,-0.02043207,0.027586767,-0.008574355,0.018129935,0.0141016105,-0.024112185,-0.017846534,-0.010544011,0.061568845,-0.07885445,-0.024593096,-0.12899442,0.04715482,-0.01030536,-0.009752375,0.050985124,0.018843926,0.054193355,0.00054513663,-0.010005938,-0.0005021526,0.11110054,0.046263743,-0.0070818844,-0.038066316,-0.040483873,0.019889437,0.04070513,-0.044466205,0.08966228,-0.0031101634,-0.07935825,-0.043517943,0.06662836,-0.04136566,-0.01162594,0.026498392,0.06393019,-0.053346977,0.04304935,0.10622809,0.065220095,0.116949156,0.09041488,-0.038196474,0.026157424,0.041351624,-0.04775016,0.023348562,0.04398571,-0.018607266,0.09422561,0.07193767,0.08611017,0.011699726,0.058904022,-0.03029503,-0.05674798,-0.041631516,-0.09343395,0.011084955,-0.07741566,0.08860367,0.06287478,0.015506841,0.12616445,0.03911305,0.0037813208,0.114935175,-0.011570764,0.018708004,0.043715097,0.052438032,-0.040856704,-0.039615393,0.0037818016,-0.026753588,-0.051919308,0.02920975,-0.004431323,0.033386838,-0.012281152,-0.0006004818,-0.09591059,0.020144826,0.06720405,0.046599727,0.029453829,-0.045326035,-0.028874908,-0.051293243,-0.0055661984,0.071457945,-4.241471e-08,0.09066061,0.025558984,0.015244352,0.00086953194,0.06500944,0.012524051,-0.013130233,0.029741352,0.030253341,-0.05722046,-0.018572656,0.102784514,0.0027632208,-0.000755051,0.03125479,-0.009226587,-0.00171835,0.059284516,-0.041447468,0.010558394,-0.006678324,0.014131443,-0.104047,-0.025017027,-0.038184132,-0.032282837,-0.010035206,-0.019756198,0.05583526,-0.029467136,0.06337321,0.035734054,0.05388989,-0.08714029,-0.08081747,0.022962973,-0.014245804,-0.026129188,-0.023423122,0.016718995,-0.08833479,-0.026546726,-0.027891591,-0.008296671,0.01956745,-0.02917923,0.007155851,0.02283545,-0.010719932,0.007127051,-0.032355215,0.0028154266,-0.03448034,0.012210782,-0.05123776,-0.035214797,0.03385303,-0.054697733,0.0021194154,-0.12333764,-0.0001277783,-0.042084835,0.13258484,-0.06271429 +2.7.7.64,"Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-Fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates [1].",384,1.0,-0.050763555,-0.085764796,0.040087294,-0.048555207,0.0010178594,-0.014176739,-0.018093953,0.016463516,-0.051195737,0.06467242,0.020704992,0.023374218,-0.00089656346,0.0126901055,-0.018726,-0.026817743,0.055062056,-0.006831503,0.06545575,0.02469683,0.13454242,-0.03006949,-0.07098493,-0.053121034,0.072437234,-0.0043091965,0.07683776,-0.058214176,-0.0045365803,-0.092635505,-0.07222021,-0.028984543,0.0629237,-0.06561708,0.03165646,0.14356993,-0.01647808,-0.012240747,0.028349651,-0.09513176,0.008501196,-0.05846965,0.06978226,-0.057324428,-0.005704094,-0.090695485,0.02825821,0.037612062,-0.01106743,0.05035736,0.002070387,0.008574023,-0.020571748,-0.010104392,0.09122397,-0.035860322,-0.10185002,0.03176553,-0.046531033,0.052538183,-0.03177036,0.03948427,-0.027642546,-0.0580075,0.048679434,-0.033250026,0.038669035,-0.071561724,0.0010086511,0.03626,-0.047133483,-0.037573364,-0.045039345,-0.061217714,-0.004336309,0.061801217,-0.013009094,-0.03913735,0.041374475,0.01675869,0.036280178,0.054661002,0.04292131,0.052783214,0.0056380024,-0.033663522,-0.009513571,0.061055154,0.030225625,-0.013461745,0.04255694,0.06536441,0.0010253822,0.05479376,-0.0643535,0.029195156,-0.094515204,0.041693054,0.043175034,-0.047003075,-0.009703354,0.069280684,0.008702626,-0.060770303,-0.017292721,0.020452091,-0.08124674,0.040431947,0.01678605,0.011463865,0.013742265,0.0740452,-0.03245346,0.039452083,-0.048802104,0.058363907,-0.020220954,-0.12608841,-0.08861482,-0.008847466,0.0066472962,-0.016401878,0.018041952,0.07466893,-0.047569282,0.0015464352,0.0032040083,3.9844968e-33,0.011624804,0.0065540513,0.023870742,-0.04028655,-0.001261209,0.040885396,-0.007817561,0.009760283,-0.018461544,0.036004234,-0.031992193,-0.028194232,0.028759403,0.06273333,-0.071124285,-0.014081622,0.024850672,0.020489197,0.08090722,0.0017360579,-0.07890588,0.11190223,-0.0039855368,-0.06140999,0.05099737,0.083301686,-0.05781232,-0.023468796,0.058303792,-0.011500668,0.054714583,-0.10905299,-0.11543037,0.031769406,0.042211667,-0.051139146,-0.078635745,-0.049571518,-0.010938496,0.013541662,-0.052895453,0.021597793,-0.050136574,0.0037178446,0.035860006,-0.00095555576,-0.03301212,-0.005916712,-0.05069935,0.042001434,0.08288635,0.016030312,0.018930027,0.04544282,-0.029845323,0.028181566,-0.03612072,-0.007772422,0.02616321,0.07896992,0.02719983,0.029662168,-0.005408506,-0.0033875974,0.016654203,0.008269943,-0.0742921,-0.06433619,0.027027495,0.06641534,0.009867248,-0.06919149,0.049170006,0.027322024,-0.041265294,-0.037118003,0.005502997,0.06041016,0.036076315,0.05708001,0.031861477,0.022642953,-0.01413704,-0.051281918,-0.08168826,0.0051564765,-0.025844533,-0.11589407,0.02284531,0.054059196,0.014986423,0.0186787,-0.06258088,0.038044836,0.0041248924,-5.5321934e-33,0.11694874,-0.09106671,0.049965415,-0.06180813,-0.10514987,-0.067175716,0.11437977,-0.09952627,0.039249558,0.0274738,0.04175663,-0.036971882,0.0005489731,-0.044966657,-0.04477284,0.026107667,0.0067641796,0.14963277,-0.044185206,0.012168426,-0.018101815,0.16905682,0.0563856,0.04088539,0.06598879,-0.017366212,0.056410342,0.016745174,0.057785902,0.05900543,-0.0006895533,0.057510633,-0.038382962,-0.08173442,-0.011348043,0.02455383,-0.057092305,0.011329794,0.0486587,0.013754256,0.0066257524,0.09131461,0.033919666,-0.02558338,0.05113368,0.0072606453,-0.04074463,0.05210313,-0.028380962,-0.094146766,0.019547349,0.003874832,-0.01646615,-0.033419065,0.042702876,0.029673267,0.030583804,-0.020132938,0.07117915,-0.050871994,-0.024684085,-0.05384083,0.03179269,-0.07237992,0.05694252,0.11468807,0.032199617,-0.030912163,0.00092079304,0.06354408,0.05055999,-0.0068250396,0.029208599,-0.0021475928,-0.013015946,0.08126208,-0.10066824,-0.010083391,0.024038857,-0.086965606,0.04054477,0.047732454,-0.041374534,-0.03502778,0.017664744,-0.08435953,0.04270273,0.09619631,0.022393603,0.022959124,-0.053971983,-0.07168521,-0.03502538,0.050952867,0.05637574,-4.6759922e-08,0.027083008,-0.060989816,0.014450041,-0.06355422,-0.03804161,0.040931787,-0.02381388,-0.04067597,0.059461024,-0.010267024,-0.014563034,0.07295879,-0.039551117,-0.0005539912,0.038712475,-0.020650594,-0.036003772,0.012566928,-0.05748467,-0.030147038,-0.05830299,0.0069844197,-0.13182501,0.038245723,-0.017253539,-0.061198305,0.029048078,0.0037250805,0.034293927,-0.05009668,0.011886966,0.044996455,0.016612364,-0.06448659,0.037479952,0.019137664,-0.05512468,0.008405116,-0.02917448,-0.009772779,-0.07508908,-0.06632295,0.07263495,-0.0251932,-0.044350244,0.037662297,-0.00997823,0.044230565,-0.0850968,0.07259425,0.016305812,-0.053837065,-0.08046586,-0.1019352,0.0026668576,0.0017468267,-0.005727832,-0.04958646,-0.022288885,-0.036727957,-0.051791783,0.017895056,0.109924026,-0.08345333 +2.7.8.27,"The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2].",384,1.0,-0.015798077,-0.07730751,-0.060206864,-0.07060123,-0.01998123,0.0027788626,-0.0026115852,0.059924822,0.033258166,0.041471843,0.0387144,-0.0012803224,-0.054579422,0.00642395,-0.0097506875,0.097726576,-0.049080055,-0.025794383,0.02138654,-0.019339005,0.03255651,-0.06874856,-0.017772611,0.030753965,-0.041465003,-0.014278968,0.06684877,-0.015704632,-0.041119333,-0.030429604,-0.024846569,-0.036171377,0.020091925,-0.034815524,-0.0032916972,0.029030636,-0.01721786,0.028964622,-0.011065067,-0.0023243516,0.06002019,-0.03369676,-0.051774267,0.016793594,-0.008774561,-0.017990975,-0.025898496,0.029156381,0.02104625,0.056650147,-0.045449853,-0.022368412,-0.04181743,0.011992796,-0.07031526,0.09063689,-0.073034994,0.046540767,0.03195032,-0.04359319,-0.043496758,-0.017113918,0.03222366,0.04373966,0.015803678,-0.048466057,0.02719817,-0.11098258,-0.013288199,0.012104149,0.0042872983,-0.111572936,0.079572685,0.00092980114,0.08818182,0.07705817,-0.003954978,0.047107033,0.052560814,-0.115366764,0.059376966,-0.05133034,-0.0049337195,0.067729145,0.034067824,0.034173295,-0.018198453,-0.020372132,0.032083653,0.011337202,-0.016578456,-0.045403104,0.016124194,0.042930864,-0.099685006,0.045521855,0.0044413386,0.038075496,-0.03667553,-0.05817742,0.02782574,0.054736044,-0.044132322,-0.08243793,0.020036167,0.04218679,0.040514387,-0.010560525,-0.05087442,0.006438439,0.009514627,-0.0049798056,0.074445166,-0.03770055,0.05684778,0.09529867,-0.05249271,-0.0060011824,0.02038694,-0.010136608,0.023436083,0.038568527,-0.04825259,0.011395151,-0.09049582,0.04816695,0.018076768,4.261677e-33,0.014354708,0.041496217,0.045097616,-0.028513862,-0.0058302428,-0.080205016,-0.0712341,-0.0716268,-0.059587892,-0.013036378,0.012992239,-0.0814188,-0.0035238082,0.037731916,-0.020520037,0.017936954,-0.0041167308,0.0048496556,0.09352993,0.002819437,-0.01792103,-0.010712867,-0.025032705,-0.026763361,0.09120447,0.03541615,-0.06447021,0.046000503,0.0021482739,0.025410784,-0.0034786083,-0.085685425,-0.075822346,-0.048981644,-0.048710592,-0.013119509,0.037567068,-0.07443498,-0.017836964,0.016284678,-0.007738193,-0.059050214,-0.030561173,0.014940133,0.033076487,-0.042337276,-0.051181775,0.027440825,0.0011658256,-0.026583321,-0.00055752054,-0.0904878,0.14541353,0.088639714,-0.0009958368,-0.0046221726,-0.01438698,-0.058759976,0.04861817,0.015636558,0.037613273,0.053087614,-0.042657945,-0.0030277004,0.061743464,0.0037039355,-0.04729437,-0.06421467,-0.1505955,0.019390764,-0.033972934,-0.016678313,0.02159994,0.0179556,-0.04851591,-0.0361267,0.033575088,0.0016256738,-0.03590567,0.0037558905,0.027095897,0.029789763,-0.031924184,0.03671798,0.0306962,0.018658295,-0.017449217,-0.05531124,-0.029648952,0.022531724,0.009212528,-0.02566481,-0.045242786,0.0634482,-0.033991,-5.6037318e-33,0.0025525233,-0.021984227,0.05103162,-0.07990571,-0.06077068,0.11511063,0.035380144,-0.010423946,0.1281263,-0.007467747,-0.050054558,-0.026878424,-0.0047652945,-0.092241146,0.0057248664,0.04824765,-0.03781524,0.0544052,0.0466882,-0.1023524,0.011492064,0.056264732,-0.038730238,0.1619313,-0.0067357104,-0.017292822,-0.010920177,0.0704397,0.028827777,0.057002854,-0.002430909,0.007852093,-0.07628201,-0.03651896,-0.0050079394,0.012277349,-0.03665238,0.056381263,0.008638464,0.013917498,-0.07872611,0.027769381,0.100581095,-0.03407613,0.07991161,0.09064062,0.012048593,0.06302911,-0.048639696,0.02155724,-0.033814978,0.037567258,-0.03224362,0.03698632,0.03913838,0.11299258,-0.012992933,0.04402923,0.05763849,-0.13859034,-0.07895855,-0.034179118,-0.019988766,0.054572765,0.090703055,0.10214883,-0.021059616,0.00649705,0.015582607,-0.0051538697,0.013816212,0.057379916,-0.119546704,0.008238706,0.011890477,0.06546156,-0.018540356,-0.014166247,0.038544882,-0.0046104523,0.05673321,0.023894409,0.13156384,-0.03555973,0.006775736,0.06390952,-0.041451696,0.05246415,0.052584816,-0.012293372,0.02876831,-0.060707875,-0.09297779,-0.02760725,0.03851594,-4.404885e-08,0.064163774,0.034378216,0.013379367,-0.12048485,-0.026068276,-0.03955155,0.038564686,-0.007501593,0.044544205,-0.08628289,-0.11217653,0.072842404,0.051394686,0.048248224,0.009047155,0.11842932,-0.010790416,0.010283947,-0.007411483,-0.044470858,0.0065870183,-0.061164815,-0.054903552,0.11600011,0.021117812,-0.014069217,0.045330744,0.07260814,-0.036499877,0.022099564,0.029854055,-0.042397793,-0.031518187,-0.017369136,0.058616657,-0.038512178,-0.0669899,-0.03743729,0.02317138,0.064321734,-0.017087262,-0.051693395,0.028283792,-0.009549014,-0.038979366,0.036651395,0.03801491,-0.009033966,0.014321686,0.007984024,-0.07573818,-0.016602602,-0.030063806,-0.08371925,-0.13928023,-0.054304156,-0.055379122,-0.015695455,0.046461795,-0.12052435,0.033040103,0.04058588,0.12883729,-0.032027353 +3.4.13.22,"A Zn2+-dependent enzyme [4]. The enzyme protects Enterococcus faecium from the antibiotic vancomycin, which can bind to the -D-Ala-D-Ala sequence at the C-terminus of the peptidoglycan pentapeptide (see diagram). This enzyme reduces the availability of the free dipeptide D-Ala-D-Ala, which is the precursor for this pentapeptide sequence, allowing D-Ala-(R)-lactate (for which vancomycin has much less affinity) to be added to the cell wall instead [2,3]. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates [2]. Belongs in peptidase family M15.",384,1.0,-0.0328564,-0.06825769,-0.09285111,-0.05566345,0.060721423,-0.023813307,-0.05304597,0.06863037,0.08365444,0.0033385293,-0.0039044092,0.0018085311,0.052975405,0.09566919,-0.05303713,-0.06715953,-0.047880717,-0.036433388,0.043556593,0.036137197,0.047321904,0.03969249,0.053986896,0.0017328596,-0.016301956,-0.037054136,0.05483792,0.053562827,0.006352847,-0.12341666,-0.0031460316,-0.035737533,0.033723775,-0.052283496,0.04491049,-0.010790094,0.0015974768,0.055344567,0.13572095,0.009965503,0.035906278,0.0028005126,0.0017789577,-0.01760731,0.023711752,-0.005666511,-0.0041215275,0.035559706,0.057284642,0.035629723,-0.039093524,-0.01284046,-0.013500492,0.089192,0.045729313,0.031560216,-0.07067427,-0.056196887,0.016517691,-0.037551202,0.069607906,0.016354276,0.05123856,0.0062611564,-0.07100625,-0.09611426,-0.036348835,-0.05112483,0.0055250344,0.013767544,-0.06657615,-0.04451812,-0.006828085,0.022146756,0.076066025,0.07751563,-0.0012581832,-0.055964395,-0.048841577,-0.047446594,0.063130304,0.069573775,0.017088573,0.113289185,0.015323353,-0.025885511,0.12472847,-0.009419463,0.04719459,0.0036790925,0.057259023,-0.042381823,0.008035969,-0.04468078,-0.057138953,-0.096736744,-0.022291904,-0.040479768,-0.024182709,0.02100811,0.020218305,-0.023941888,0.010344232,-0.05868407,-0.014698192,0.035483345,0.012216974,0.048101395,0.059927974,-0.010475461,0.0036990228,0.019263413,-0.009428122,-0.006300324,-0.091141365,0.07982593,0.047857333,-0.09032148,-0.009199263,0.013720015,0.0013905353,-0.009447094,0.025515052,0.013969312,-0.036731295,0.02551425,-0.06948509,-5.2287e-34,-0.0047589494,0.010705589,-0.020478163,-0.021394819,0.055498812,-0.020018151,-0.056105573,-0.039731413,-0.0057077,-0.034449212,-0.113533124,-0.110575736,0.019152964,0.115256734,-0.07204337,0.029366095,-0.022676844,0.025991833,-0.049485154,0.032908004,0.02029143,0.04487523,-0.003173845,-0.034978952,0.17469989,0.03681608,0.012953374,0.031788085,0.08275307,-0.013213648,0.0034288107,-0.04503741,-0.030698963,0.0017458467,0.10342788,-0.013353262,0.013645108,-0.06882607,0.07402051,-0.019880252,-0.015076615,0.040336587,-0.016254637,-0.012435048,0.059221145,-0.045512665,-0.051303793,0.08978214,-0.022038115,0.025039293,0.09026677,-0.03254804,-0.020865666,0.002665396,-0.084243275,0.0009416351,-0.054699603,0.0005364327,0.071822986,0.03235061,0.065460354,0.033008832,-0.017346468,0.008827514,-0.013837252,0.039347194,-0.073499635,-0.035270825,0.04579161,0.01677364,-0.10944907,-0.04470086,0.033190772,0.015827794,0.02916029,-0.048706297,-0.046528228,0.0029035322,0.09578603,-0.01686309,-0.021775708,0.021675248,-0.00051709503,-0.009323032,-0.07149413,-0.012599481,-0.02247018,-0.06819297,-0.05596426,0.01692337,-0.009651966,-0.021308346,-0.10054775,0.048893113,0.01166541,-1.963568e-33,0.098655045,-0.10717485,0.105391756,-0.05353128,-0.06817607,0.031954926,-0.018017367,-0.023188958,0.06534683,-0.06280263,0.06806281,0.02871781,0.040868115,0.01197786,0.04578095,-0.037155427,-0.045171443,0.04820066,-0.0616957,-0.0019449174,-0.020039506,0.013785662,-0.020729447,-0.032697715,0.0040544667,0.06009113,-0.011235712,0.048083376,0.024122698,0.032144327,-0.060751658,0.031165348,-0.07719465,-0.040186476,-0.05721517,0.056334205,-0.014452037,-0.06325751,-0.09329854,-0.035900295,-0.0047520846,0.018078974,0.014068099,0.025212975,-0.009164726,0.002913099,0.0020164563,0.030127373,0.03837475,-0.017482577,0.023465808,-0.012069124,0.0685778,0.07479808,0.030236855,0.020950265,0.05442538,0.011440836,0.022097109,0.026852796,-0.039120894,-0.024414966,0.036165558,-0.010938145,0.044057593,0.0085818805,-0.061819557,0.064323395,0.082558945,-0.044700604,0.0704726,0.08040245,0.029967237,-0.030376913,-0.05665898,0.083131455,-0.08761158,-0.09120709,0.025313256,0.0015448667,-0.04488239,-0.050242886,-0.05303017,0.0008315894,-0.03473604,-0.009101274,0.03928967,0.04662615,-0.030802254,0.027949544,0.013005888,-0.045193225,-0.020979555,0.016486736,0.024486085,-5.1388113e-08,0.052483596,-0.03220822,-0.005407117,-0.009703542,-0.05490028,-0.059703995,-0.06843939,-0.059599187,0.02696141,-0.05476126,0.053330686,0.09614764,-0.02601568,-0.027346263,0.009646305,0.10802289,-0.08838612,0.008273767,0.0054534674,0.060360685,-0.12142618,-0.01590871,-0.11450661,-0.002515921,0.08235363,-0.08847937,0.016141603,0.019912306,-0.060471177,-0.023220042,0.049649023,0.0047585354,-0.035117373,-0.046838533,-0.026615813,0.024749639,-0.10000078,-0.042005334,0.023146212,-0.01229728,0.11998238,0.01745818,-0.06261833,-0.063497365,-0.029926866,0.03216739,-0.022127816,0.026820248,-0.09545049,-0.029720742,-0.013919977,0.039808992,0.018863903,-0.024033925,-0.06165885,0.042654913,-0.048922434,-0.07580357,0.017351111,0.009047864,-0.05267275,0.013087026,0.20459534,0.03692608 +3.5.2.18,"Contains iron and Zn2+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 1.1.1.291 (2-hydroxymethylglutarate dehydrogenase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase). ",384,0.99999994,-0.010373193,0.015590119,-0.08644387,-0.025620624,0.037781876,0.05560401,-0.04508828,-0.018585794,0.0046036365,-0.030609855,-0.012283139,-0.122824594,-0.04563114,-0.054738197,-0.035288624,-0.039340723,-0.064877264,-0.032095402,-0.021497605,-0.050559275,0.067919634,0.04779555,0.020767538,-0.017699486,-0.045797214,-0.004928285,0.061534394,-0.058152843,-0.07980724,-0.08043267,-0.024014225,-0.04275509,0.043140892,-0.04561185,0.040937785,0.031702403,-0.04417932,-0.08505228,0.060791936,0.033594325,0.082201265,0.013741608,-0.025086427,-0.046470687,-0.052502215,0.02882779,0.07712534,-0.04224801,-0.0022706194,-0.015406987,-0.0887884,-0.051373966,0.01209707,0.018354772,0.036593646,-0.047042634,-0.011999663,-0.008629538,-0.0014740813,-0.019200012,0.060537644,-0.037635747,0.03161235,-0.03149579,0.012737454,-0.030335661,0.057258192,-0.07523386,0.020535912,-0.065461375,-0.098209254,-0.06150966,-0.023024734,0.029611334,-0.062416673,0.055367317,0.040184345,-0.007937421,0.030476892,-0.030098647,-0.041096877,-0.0022154588,0.021767741,0.06806556,-0.00015507187,-0.018907525,0.006662058,0.01406586,0.056855995,0.06647024,0.047780175,-0.008374175,0.003715893,-0.0194053,-0.058446888,0.040384874,0.05241908,0.059470776,0.05569874,-0.071258195,-0.01764093,0.09168311,0.022573361,-0.060580283,-0.053613767,-0.012190323,0.04720088,0.11654129,0.049947318,0.015097339,0.03877447,-0.03700617,0.008100125,-0.032684278,0.04393611,0.05792136,0.07400694,-0.061696798,-0.050250724,0.02796721,0.036072254,-0.014081185,0.14405356,0.07509089,-0.021861948,0.014102278,-0.17553937,3.7784146e-33,0.06943578,0.007531373,-0.005263139,-0.006924305,0.06533033,0.044820864,-0.10725829,0.031569183,-0.021494174,-0.042487655,-0.09798852,-0.031206464,0.044289853,0.006879715,-0.057566445,-0.0069089686,-0.06684745,-0.02604466,0.0407474,0.0143505465,0.06818924,0.036043033,-0.010171119,0.011552066,-0.010547182,0.041772634,-0.006707161,-0.037602413,-0.025041021,-0.024426267,0.049516033,-0.1500424,-0.10607692,-0.06399009,0.078519866,0.031094419,-0.0063254475,0.0457943,-0.03434146,0.041654676,0.06286481,0.0069455383,0.03941839,-0.022999289,0.04821442,-0.038082086,-0.093715526,0.08007007,0.08869081,0.047449753,-0.027110118,-0.03758198,0.15132435,-0.0803367,-0.06978506,0.03665454,0.004344745,0.061874315,0.028660538,0.10056097,0.03500613,0.08402823,-0.033020936,0.068356864,0.0028016937,0.024735413,-0.02876557,-0.024792632,0.034580793,0.0011458304,-0.09228053,-0.034790218,0.1458486,-0.0018789924,0.02266675,-0.08540619,-0.09865069,-0.035472244,-0.028362013,0.061377663,-0.058145016,-0.026922418,0.008559202,-0.008854403,0.0020027754,-0.0004984544,-0.033515252,-0.016818525,0.013880476,0.035643443,-0.0060178465,0.00091247685,-0.06025316,-0.0006175041,0.016905837,-4.8171145e-33,0.08844419,-0.05034201,0.08602413,-0.089221224,-0.013100589,0.06644039,0.054095156,0.010722423,0.0054169777,-0.036178194,0.11608405,0.011990788,0.00614215,-0.03893601,0.0014816701,0.023086892,-0.028095886,0.099004515,0.04372327,-0.018980436,-0.020826507,0.043928005,-0.012496721,-0.020033125,0.047159865,0.027217641,0.031784717,0.042192232,0.032801922,-0.005608965,-0.0059125214,0.07853155,-0.018652584,-0.094091795,-0.10756003,-0.013379346,-0.097167104,-0.034887366,0.041685008,0.0075581195,0.04395055,-0.0329583,-0.01052767,0.030854093,0.038926292,0.03646843,-0.0697835,0.03551419,-0.03617015,0.059890937,0.038334027,-0.045432117,-0.059682105,0.04600803,0.052995943,0.03863576,0.0039283712,0.0780561,0.00074568443,0.008775284,-0.022242785,-0.02574956,0.089686595,0.037762433,0.036930963,0.04594369,0.005961257,0.07890101,0.044253826,-0.015887596,0.101393834,-0.0052078683,0.012062838,0.01955209,-0.016933607,0.023985056,-0.07472339,0.011983606,-0.021361262,-0.02389516,0.028264591,-0.014422151,-0.010941827,-0.025558345,0.013230665,-0.007838389,0.020491274,0.047306005,-0.017210789,0.008890627,-0.048345026,-0.0862393,-0.033978242,0.030215321,-0.036793705,-4.5381924e-08,-0.014791659,-0.055586647,0.027524147,-0.007822606,0.057242494,0.026074307,0.007862727,0.041305564,0.008850404,-0.029953502,0.044754338,0.037501153,-0.011953766,0.030540967,0.06182448,0.033270046,-0.043444943,0.05588067,-0.0037994427,0.041027866,-0.07390692,-0.017426262,-0.06906692,0.045351204,0.023020437,-0.047956705,0.0091193225,0.0032050435,0.04381843,-0.0930601,0.0068307756,0.0034676816,0.0747119,-0.05584876,-0.111226186,-0.016736692,-0.07349326,-0.06617298,-0.083512396,0.031958096,-0.017365836,-0.076323,-0.040965322,-0.025195196,0.008961708,0.036310796,-0.04024335,0.07405996,-0.028547952,-0.06512827,0.0043616476,0.025728943,0.040358994,-0.047649126,-0.13179983,0.066523194,0.007448568,-0.07299917,0.0501747,-0.008108413,0.0784558,-0.014900038,0.11905059,-0.04019207 +4.2.1.110,"This enzyme catalyses two of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. Aldose-2-uloses such as 2-dehydroglucose can also act as substrates, but more slowly [1,2,4]. This is a bifunctional enzyme that acts as both a lyase and as an isomerase [2]. Differs from EC 4.2.1.111, which can carry out only reaction (1a), is inhibited by its product and requires metal ions for activity [1].",384,1.0,-0.010477729,-0.07371363,-0.032136977,0.029256899,0.0768427,0.008297062,-0.08146049,-0.022145554,0.0037249743,0.0035585037,0.022893569,-0.031735517,-0.10375633,-0.008718286,-0.07474139,0.05017688,-0.018901808,-0.04395957,-0.029068254,-0.0491883,0.10980688,-0.04805616,-0.06233822,4.3370153e-05,0.08111497,-0.019850262,0.01243638,-0.075011864,-0.039934695,-0.07907293,-0.008357872,-0.10755183,0.052955877,0.0020585547,-0.008777712,0.09715383,-0.0074111735,-0.063642,-0.020003228,-0.0034478065,0.0064050383,-0.092170514,-0.028690172,-0.046987224,-0.040949892,-0.027516404,-0.026774395,-0.023809565,0.012519511,0.013477177,-0.009803223,-0.07456539,-0.00043353185,-0.012603593,0.031580698,0.03120948,-0.03829685,0.0458471,-0.038553424,0.08524184,0.062284034,0.0369094,-0.056062613,0.015686313,-0.0065742657,-0.047332015,0.06231727,-0.10533219,-0.040792305,-0.0239891,-0.04302814,-0.10149229,-0.050170813,-0.039160386,0.065108895,-0.0008449317,-0.03220153,-0.09205463,0.012174642,-0.0013352577,0.05185064,0.025472278,0.08681233,-0.037301436,-0.023069073,-0.05065952,0.028639682,-0.007703605,0.013891379,-0.0111481575,0.042184517,-0.007359709,-0.013024851,0.025279742,0.017309835,0.0577901,0.06228314,0.00025820383,0.048008192,-0.055026513,-0.025302706,0.10767067,-0.019530054,-0.0606106,-0.016301658,0.04450552,-0.012405759,0.0779067,0.016105818,0.016577315,0.027974296,0.015426215,0.02785139,0.03125046,-0.033371683,0.083361894,0.023128849,-0.065937765,-0.041710634,0.007860617,0.027288685,0.02873846,0.05863055,0.11555486,-0.028041383,0.044102315,-0.057046857,1.9330026e-35,0.10477895,0.0041335053,-0.03377517,0.0020463748,-0.0055766776,-0.0048279758,-0.08238023,0.055369105,-0.016886054,-0.013196189,-0.018350845,-0.051414814,0.048722755,0.07745401,0.039602384,0.0027945153,0.06221197,-0.054028694,0.11788441,0.013137109,-0.02778519,0.0349596,-0.029320488,-0.01794622,0.034740116,0.08349894,0.0043417676,0.0030071724,0.019615049,0.004428445,0.003806697,-0.08211055,-0.08867047,0.03955581,0.034474824,0.00083765754,-0.032829653,0.05346948,0.01212826,-0.0077005606,0.014266655,0.03645576,-0.009475366,-0.090261705,0.05399388,-0.036218233,-0.013704127,0.09241168,0.0052563315,0.092987604,0.05388108,-0.038141817,0.037484407,0.057639882,-0.07688202,0.049056742,-0.0197173,-0.056280594,0.01430839,0.085116975,0.032732178,0.1433649,0.033688374,0.031102493,-0.01823411,-0.0017642793,-0.074737675,-0.03247419,-0.062396232,0.06671804,-0.099589095,-0.025906304,0.11117181,-0.011467405,0.0030164528,-0.08776971,-0.041833077,-0.0006964459,0.0112346,0.018052801,0.0063333535,0.032627176,0.051515426,-0.0037304407,-0.064970665,-0.05593781,-0.06351674,-0.020089582,-0.03486048,0.025898267,-0.035819676,0.018585607,-0.0046810466,0.033507198,0.04265098,-3.6903642e-33,0.1775042,-0.14300355,0.08213047,-0.06822271,-0.056877073,0.0685239,0.017006794,-0.05134406,0.023030926,0.005998246,0.057674956,0.039315637,0.01041494,-0.08714714,0.04587031,-0.010874585,-0.08394383,0.07527564,-0.04901229,-0.008798335,0.011509861,0.11376378,0.003118791,0.022234725,0.071544535,-0.06939383,0.037510466,0.0046775625,0.03980253,0.035181798,-0.016597273,-0.011534781,0.0037991258,-0.06956088,-0.051210664,0.06028343,-0.07849681,0.03956222,-0.038669426,0.027181167,0.019898541,0.06295474,0.009182421,0.02797304,0.057500046,0.049512696,-0.06253246,-0.01918003,-0.009629087,-0.07993312,0.030006181,-0.002926378,-0.053574193,0.013625309,0.029213011,0.08215596,0.022494663,-0.003428187,-0.049521595,-0.022558099,-0.03801884,-0.019425988,0.07217853,-0.032185193,0.05633935,-0.02109558,-0.024589533,0.045347672,0.011876216,0.043311674,0.13022184,-0.030932639,-0.025154285,0.047536757,-0.020601965,-0.030310089,-0.07195314,-0.024786701,-0.012562987,-0.022661481,0.023961227,0.014025862,0.035740104,-0.04866514,0.002022972,-0.12203931,0.061404914,0.08757691,-0.04991437,-0.016114788,0.007905135,-0.007304474,-0.022888385,0.008608253,0.049256958,-4.2807805e-08,0.003454615,-0.029184828,0.0033565692,-0.067731746,-0.040983476,0.03737306,0.051917464,0.047057886,0.014545807,-0.029606164,-0.07207185,0.08916618,-0.00359173,0.009829825,0.010959167,0.013855871,-0.042389613,0.04246341,-0.0025311096,0.058381762,-0.116321094,-0.04232548,-0.15644577,-0.041195635,-0.06579463,-0.06446029,0.069857724,0.09314476,-0.009143548,-0.020822788,0.013464597,0.059402395,-0.0020188878,-0.02635649,-0.024893554,-0.042035524,-0.028176818,-0.036059763,-0.041280422,0.026531095,-0.023242243,-0.0014743244,-0.011835601,0.0009690608,-0.02199813,-0.0005188722,0.035366572,-0.03248086,-0.008370596,0.08557119,0.06197907,-0.012986396,-0.05366434,-0.06507322,-0.028531298,-0.0032177984,-0.012889926,-0.07284521,-0.008150957,-0.054598626,0.103618756,-0.056011245,0.14420968,-0.022537082 +4.2.1.111,"This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.2.13 [exo-(1->4)-alpha-D-glucan lyase] and EC 5.3.2.7 (ascopyrone tautomerase). Requires divalent (Ca2+ or Mg2+) or monovalent cations (Na+) for optimal activity. Unlike EC 4.2.1.110, the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity towards aldose-2-uloses such as 2-dehydroglucose [1,2,3]. In addition, it is inhibited by its end-product ascopyrone M [2] and it cannot convert ascopyrone M into microthecin, as can EC 4.2.1.110.",384,1.0,-0.029276963,-0.05742416,-0.075331174,0.0009188919,0.073328756,-0.027240789,-0.08279583,0.04008952,0.004526531,0.022728823,-0.013627972,0.024588872,-0.021996828,0.03456685,-0.08581723,0.051364876,0.00031873715,0.005662134,-0.035378598,-0.023583412,0.12372218,-0.047477506,-0.010963262,0.01336983,0.077032395,-0.03402026,-0.0038662076,-0.024563868,-0.097638726,-0.11261193,-0.0056900363,-0.074223615,0.049625747,0.005376385,0.025538566,0.09560488,-0.041926835,-0.043859784,0.008203343,-0.0059731673,-0.028605888,-0.035551418,-0.0209431,-0.01372395,-0.034476,-0.059934344,-0.07071592,0.022455463,0.05279833,0.057070334,-0.025584793,-0.050433118,-0.033392794,0.025713578,0.04248343,0.009812317,-0.071249604,0.04116926,-0.03855024,0.04051864,0.046489842,-0.027421499,-0.016849427,-0.01393354,-0.03353489,0.0024746351,0.02022585,-0.09638512,-0.012885645,0.011736495,-0.036214888,-0.09671171,0.024048785,0.050277937,0.068313114,0.008362636,-0.02073548,-0.068674855,-0.0007718053,0.017636955,0.039649304,0.030251551,0.07684337,-0.022808008,0.03341186,-0.030079378,0.05905877,0.023541922,0.06569599,0.044405542,0.071062475,-0.01617384,-0.03731922,-0.004426812,0.02208352,0.0051478758,-0.011055506,0.00013388478,0.031181676,-0.07546211,0.028727183,0.083002076,-0.04678068,-0.030883823,0.0054382887,0.030052315,0.055164948,0.046252836,0.032758545,-0.015286001,0.0047703367,-0.030649211,0.026913017,0.0070281452,-0.07253311,0.0950915,0.020605229,-0.05858068,-0.058931585,-0.0025011967,0.0496752,0.047100645,0.060551487,0.10634299,0.01913872,0.07210337,-0.10107802,2.6598954e-33,0.04626855,0.035520244,-0.0040167645,0.007078686,0.02000865,0.021520076,-0.07335242,0.052473016,-0.02057493,-0.038263325,-0.07236749,-0.06270007,0.04982351,0.036446832,-0.0019285586,-0.040205095,0.056777332,-0.0682917,0.031335372,0.020921273,0.046933897,0.019256512,0.004374625,0.024779921,0.007127002,0.069324285,-0.009359663,0.0688726,0.059575703,-0.0042849914,-0.038872335,-0.102420725,-0.087843604,0.058669075,0.0005806035,0.0051636705,-0.07998038,0.02893404,0.07677764,0.06437149,-0.01634662,0.055660475,0.0061156615,-0.04729753,0.030920718,-0.05124206,-0.002367094,0.12039613,0.021858409,0.070183836,0.06084623,-0.045392785,0.031735506,0.005533637,-0.09103972,0.034995455,-0.06723125,-0.033013176,0.010528691,0.06953971,0.020597842,0.07466983,0.022887766,0.015760154,-0.020536587,0.004230935,-0.08660281,-0.0012457197,-0.07185483,0.06250033,-0.061422255,-0.038697373,0.11979838,0.04245951,0.038762685,-0.03335862,0.0013171842,0.01500546,0.013164001,-0.01660492,-0.028173085,0.01470613,-0.017579107,0.023474174,-0.074846566,0.009576331,-0.0348684,-0.06536665,0.030878663,0.080258325,-0.031554855,-0.048253767,-0.048232846,0.018561503,-0.002124368,-3.627305e-33,0.15008906,-0.10533954,0.081566975,-0.03518315,-0.057113864,0.108257495,0.051547796,-0.09677304,0.07174607,-0.050491545,0.06656429,0.033187058,-0.014343948,-0.09300734,0.03906639,0.00633019,-0.09338849,0.089169905,-0.059820905,0.027250413,0.0092375865,0.089477584,-0.055618703,0.024823649,0.0677056,-0.015649151,0.011901141,-0.0071847425,0.062202636,0.02260706,-0.013773395,0.026520833,-0.0340651,-0.03388592,-0.03158827,0.09405558,-0.054164216,0.017292604,-0.057796724,0.035786964,0.027799327,0.0915896,-0.015860248,-0.0017956864,0.052470066,0.042929403,-0.07360335,0.0035665338,-0.009363072,-0.04017316,0.01193385,-0.026048634,-0.021451458,0.047724333,0.022974882,0.06733367,0.038041297,0.016341155,-0.05614606,0.004184058,-0.032586426,-0.026489992,0.07366461,-0.08971288,0.07236881,-0.016454346,-0.011599949,0.05638469,0.002358266,0.08599149,0.04710224,-0.04800085,-0.005767464,0.035361752,-0.0056507005,-0.008240332,-0.0660734,-0.03413687,-0.017551573,-0.048401818,0.01562872,0.022970056,0.013239439,-0.02252411,0.003927008,-0.055645425,0.086285114,0.094377145,-0.01330445,0.02968613,-0.02861545,-0.04529316,-0.011278273,0.030275578,0.08385968,-5.058355e-08,0.05724321,-0.024230376,-0.024651285,-0.063876584,0.02112765,-0.0085665835,-0.012440864,0.0276271,0.009284397,-0.028849954,-0.027929416,0.09167077,-0.0015708997,-0.021888005,-0.039538268,0.011438436,-0.0272365,0.044562545,0.016958427,0.056351256,-0.16254324,-0.03124017,-0.22310452,0.00477067,0.012608389,-0.06894424,0.04629762,0.0874175,-0.0045808796,-0.04501286,0.009213056,0.033181485,0.016781555,-0.08003111,-0.04839972,-0.030638538,-0.05416277,0.019189268,0.0054464852,0.053231828,0.030802103,-0.0038930904,-0.0073910914,0.0066383947,-0.0410987,-0.043754715,-0.01322172,-0.041670993,-0.036776047,0.09910729,0.05810235,0.024379946,-0.053323206,-0.051488142,-0.05832911,0.0098518655,-0.023312757,-0.07700052,-0.00050383393,-0.08885141,0.03371016,-0.060169026,0.13561064,-0.046856984 +5.3.3.15,"This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.1.111 (1,5-anhydro-D-fructose dehydratase) and EC 4.2.2.13 [exo-(1->4)-alpha-D-glucan lyase]. Ascopyrone P is an anti-oxidant [2].",384,1.0,-0.03745515,-0.0318518,-0.10862791,0.038700983,0.086087435,0.014699699,-0.06333437,0.008661921,-0.01553489,-0.013189807,0.0023414674,0.07245969,-0.076913446,-0.026309209,-0.12693933,0.06440749,0.006137664,-0.039357603,-0.02125992,-0.02924596,0.05604762,-0.049715977,0.0032511377,0.020629125,0.08573673,0.021379216,0.031244291,-0.078143775,-0.07790863,-0.08980693,-0.0064385394,-0.08025817,0.08888598,0.0076935547,0.019338055,0.07043783,-0.040359277,-0.053409286,0.030937232,0.006272239,-0.0076394803,-0.056600835,-0.042296547,0.010600303,-0.03175694,-0.03197826,-0.10694016,0.012764408,0.07002528,0.038328372,0.001556092,-0.0415005,-0.05722358,-0.0044213706,0.004410696,0.028125875,-0.05356384,0.012972693,-0.040708814,0.060227945,0.036188964,0.03247347,-0.04417864,0.008400659,-0.010070174,-0.012188202,-0.019192146,-0.04786478,-0.02269997,-0.0086948695,-0.039648004,-0.055763006,0.023533305,-5.719502e-05,0.029989304,-0.026630742,-0.041693076,-0.049308114,0.0073286984,-0.0062814625,0.09178296,-0.0076841456,0.092718735,0.0077106664,0.040406644,-0.05030955,0.019913342,0.031764954,0.05716491,0.028679641,0.047065023,-0.03417037,-0.036152475,0.037761394,-0.0052980306,0.025775475,0.06174127,-0.027020855,0.034191787,-0.0829054,0.012817404,0.07043828,-0.036833473,-0.032027464,-0.03973946,0.048824675,-0.008824372,0.015972681,0.07278173,0.016522747,0.009708604,-0.026523123,0.009630233,0.0030893153,-0.06534355,0.09119958,-0.0012184881,-0.008308962,-0.08383202,-0.0017530889,0.03075878,0.03959885,0.088071436,0.11034372,0.0019352965,0.039537597,-0.06317421,8.346582e-34,0.03306194,0.036807075,0.008999699,-0.00582925,0.043092415,0.009950638,-0.077762015,0.034454394,-0.00022988571,-0.05564724,-0.067907125,-0.089018546,0.06275457,0.031574357,0.0057714204,-0.028585475,0.01847523,-0.06729214,0.04751883,0.027534883,0.03270748,0.014981326,-0.002025435,0.008042806,-0.014424102,0.047097832,-0.055204555,0.11827231,0.049129393,0.008830555,-0.019802054,-0.076477565,-0.09317273,0.037011966,0.0060057566,0.03259693,-0.09002804,-0.016587133,0.01956327,0.050072726,-0.034494277,0.000386772,-0.019770231,-0.08213805,-0.005001782,-0.04267238,-0.018903997,0.13356113,0.04877731,0.0691956,0.013996608,-0.04746019,-0.00016960072,0.045359794,-0.06432432,0.016794553,-0.058440156,-0.022591682,0.009397831,0.09332051,0.08725965,0.07316135,0.0059607658,0.0013065396,-0.040503126,-0.009022703,-0.03882442,0.012286176,-0.05669542,0.043905914,-0.06640518,-0.057780202,0.09491521,0.016693803,-0.02000869,-0.01444531,-0.00060241536,0.062461555,-0.030784454,0.009847288,-0.024511604,0.014765866,0.035061218,0.012187915,-0.06375118,0.018244479,-0.0050941007,-0.04640308,0.023611816,0.03285857,-0.0072647925,-0.021543792,-0.044471454,-0.0020681554,0.023226585,-2.7271673e-33,0.1312742,-0.13047439,0.08325329,-0.06527109,-0.05982605,0.06720765,0.07461539,-0.09565443,0.044807993,-0.0053195725,0.03946135,0.043549024,-0.03055925,-0.12245734,0.08031702,0.004424777,-0.05779384,0.08533578,-0.088906325,-0.02165391,0.043219022,0.09602392,-0.031879846,0.032301422,0.016099976,-0.02146815,0.030093867,-0.0599393,0.027764967,0.07007173,0.02108207,0.035957076,-0.031462606,-0.040923804,-0.011835884,0.07817009,-0.090271994,0.025839819,-0.037615284,0.04077081,0.027094416,0.13556413,0.008875053,-0.0017093633,0.09822528,0.01909725,-0.11950922,0.009836797,0.019047722,-0.08647988,0.02908205,-0.011591972,-0.014386318,0.03291438,0.034797046,0.06132808,0.02486291,-0.0008080165,-0.027263226,-0.032549966,-0.048311055,-0.048890166,0.06514372,-0.037197758,0.062351003,-0.047303278,0.02619148,0.05515567,0.037786473,0.04907972,0.046567034,-0.025534788,-0.05016708,0.10880506,-0.04175344,-0.03987619,-0.04586224,0.01871883,-0.013114535,-0.0050169253,-0.015252632,-0.011374948,-0.0030232759,-0.017268864,-0.0336193,-0.09046605,0.040722452,0.093594424,-0.0009332968,0.010285118,0.015374858,-0.018107807,-0.036891326,0.025679192,0.09937616,-4.209797e-08,0.034682505,-0.06990142,0.016956609,-0.056834996,0.02555281,0.012379842,0.009360656,0.051704563,0.030290958,-0.041910805,-0.051095404,0.10106902,0.026742173,-0.046298232,-0.04809827,0.027760657,-0.016352028,0.07820467,0.022940852,0.035217267,-0.11301239,-0.03333795,-0.16065075,-0.0032265855,-0.0046981927,-0.07476478,0.07869334,0.086895525,0.014089419,-0.042788494,0.015012631,0.017296787,0.0706991,-0.10197721,-0.013758123,0.011271597,0.03161924,-0.019464001,-0.008990399,0.09288363,-0.03211229,-0.003867605,0.026411885,0.0022565464,-0.031391073,-0.0021027713,0.0004561491,-0.020462308,-0.034054656,0.06661631,0.04387654,0.032926396,-0.061275683,-0.049367793,-0.061392043,0.00083981466,-0.05976074,-0.06576429,0.0061571207,-0.0943727,0.041116532,-0.020224579,0.15698238,-0.0077238865 +6.3.1.12,"This enzyme forms part of the peptidoglycan assembly pathway of Gram-positive bacteria grown in medium containing D-Asp. Normally, the side chains the acylate the 6-amino group of the L-lysine residue contain L-Ala-L-Ala but these amino acids are replaced by D-Asp when D-Asp is included in the medium. Hybrid chains containing L-Ala-D-Asp, L-Ala-L-Ala-D-Asp or D-Asp-L-Ala are not formed [4]. The enzyme belongs in the ATP-grasp protein superfamily [3,4]. The enzyme is highly specific for D-aspartate, as L-aspartate, D-glutamate, D-alanine, D-iso-asparagine and D-malic acid are not substrates [4]. In Enterococcus faecium, the substrate D-aspartate is produced by EC 5.1.1.13, aspartate racemase [4]",384,0.99999994,-0.06854726,-0.12148579,-0.047653157,-0.052479025,0.027957786,0.02515949,-0.07895936,0.03482752,0.08010403,0.016854035,0.05235857,-0.020268789,0.00844345,0.07483348,-0.060085855,-0.074283086,-0.045533694,-0.042313702,-0.033598512,-0.010669043,0.06887422,0.07875806,-0.03217088,-0.05326144,0.05790419,-0.02899586,0.079273045,-0.023262048,0.03824572,-0.11931676,-0.060948458,-0.09772862,0.06602906,-0.0138464505,0.03615565,0.05519072,-0.036370497,-0.018910304,0.13633096,0.01666557,0.046150092,0.0320403,0.034169536,-0.03722256,-0.027267823,-0.0028319196,-0.021124922,0.092433326,0.06772907,-0.009503659,0.027810704,0.0014914491,-0.022281172,0.018952146,-0.06689845,0.016675904,-0.024693869,-0.043549478,-0.0083235195,-0.012107786,0.03811269,0.051158555,0.06995027,0.010878805,0.004886893,-0.08766676,0.007291431,-0.042630404,-0.00030636234,-0.020284113,-0.09121822,-0.102585174,0.06228594,0.1086588,0.09370204,0.03129726,0.010242538,-0.045179825,0.018434675,-0.049745012,0.054172166,0.049339533,0.032090213,0.065788485,-0.004982714,-0.069606,0.037588924,0.056837723,0.09515626,-0.011961423,-0.01041824,-0.088430405,-0.037903093,-0.060133293,-0.007286655,-0.032581016,0.024496468,-0.001074505,0.0030240857,-0.047220692,0.018822405,0.05592418,-0.00029585767,-0.03452838,-0.016421817,0.004256447,-0.07076155,0.0687968,0.033671096,-0.047758304,0.01525672,0.024609817,0.012739758,-0.0229242,-0.034950204,0.018648809,8.7563065e-05,-0.09647251,-0.053053096,-0.007523624,-0.014588963,-0.052716963,0.038365044,0.10480735,0.015418153,0.041631095,-0.091729365,1.968008e-34,-0.0003925085,-0.023483815,-0.006922284,-0.073464096,-0.025811268,-0.022914136,-0.088857315,-0.024869462,-0.06589894,-0.0504829,-0.04842544,-0.085240565,0.049731743,0.021886783,0.008274119,0.022857815,-0.01492598,0.016634159,-0.034165803,-0.0002736152,-0.013251055,0.05528768,0.0037278135,0.023706738,0.112431385,0.015954044,0.013679362,0.03221766,0.055629767,-0.01306858,-0.046156935,-0.09998263,-0.086934105,0.027452072,0.050293494,0.014228538,-0.053197246,-0.051371604,0.049967743,-0.033293407,0.022945203,0.0445721,-0.018281318,0.002531691,-0.046722963,-0.04137901,-0.0048799315,0.07945172,-0.0022038966,0.051844403,0.08730357,-0.036453266,0.10483696,-0.08221375,-0.054808386,0.0012059528,-0.10639686,0.021392718,0.09116825,0.061794497,0.08954808,0.014031824,-0.055400133,0.0743135,-0.008111182,0.012200574,-0.01597455,0.014724884,0.07355082,0.0813937,-0.11351398,-0.06005827,0.07581528,0.05363651,0.040753245,-0.040764265,-0.01788147,0.037367254,0.034148738,-0.0063091475,-0.0080644,0.030959664,0.0025439528,-0.018150989,-0.041303236,-0.026369825,0.017924773,-0.045739833,-0.0071967314,0.04190799,0.008417587,-0.029105846,-0.063639395,0.08935201,0.020669732,-2.1655844e-33,0.09192719,-0.11518437,0.09450046,-0.080429085,-0.11255585,0.01375435,0.06682514,0.013468103,0.033911217,-0.05208814,0.07286271,0.07887277,-0.029322362,-0.015185911,0.013963883,0.01661111,-0.034875218,0.10255722,0.007398913,0.02893179,-0.00016820247,0.029958345,0.01622364,0.014884746,0.0058468776,0.021845378,-0.017103313,0.06325319,-0.02671234,0.04359456,0.04202169,0.071197905,-0.04801134,-0.01961479,-0.12660134,0.010628375,-0.033497043,-0.047535036,-0.021766173,-0.014066902,0.040483154,0.10161181,0.024074556,0.024733117,0.00588282,0.03139113,0.026634887,-0.005018317,-0.002772626,-0.055050693,0.02127284,-0.027641444,0.09474928,0.030440899,-0.016913407,0.057718597,0.036569368,0.04312955,-0.016015569,0.019019557,-0.042178698,-0.048349395,0.01894587,-0.044615928,0.05367409,-0.034417134,-0.03865293,0.03164721,0.012096579,-0.021163857,0.02076805,0.03393883,0.029677648,0.001248851,0.016571129,0.00089909625,-0.046697136,-0.021218233,0.015514695,-0.018594975,-0.0749696,0.0038752058,-0.070446506,0.029611243,-0.020593956,-0.04366656,0.008862494,0.10996195,-0.009220846,0.05376538,-0.014743552,-0.08729677,0.01998225,0.04709716,0.119414486,-4.8623804e-08,0.06370442,0.0022345444,0.030639546,-0.05736339,0.015296328,0.08049158,-0.073330596,-0.050010685,0.03702691,-0.041066967,0.019063573,0.0282457,-0.059774812,-0.035013348,-0.03127367,0.046739906,-0.115457505,0.05889808,-0.0029166657,0.057579234,-0.053978298,-0.022067852,-0.09008484,0.055522963,0.041402973,-0.016569944,0.030949198,0.009249612,-0.053255968,-0.037742585,-0.007759227,0.025982784,-0.041861597,-0.081477,-0.04408144,-0.027964996,-0.050812777,-0.021861391,0.021024808,0.06467624,0.08813002,0.01487161,-0.043282036,-0.023897327,-0.0126119405,0.08071817,-0.06524943,0.04175657,-0.08229766,-0.019754877,0.016156463,-0.014064555,-0.01550214,-0.05238445,-0.061049867,-0.009158744,-0.055681933,-0.091693744,-0.0003941599,-0.0008916433,-0.012354367,0.013937869,0.16888614,-0.00058043195 +6.4.1.7,"A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought [1] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, isocitrate dehydrogenase (NAD+), but this has since been disproved [2]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41 [2].",384,1.0,-0.08664199,-0.022183493,0.027901381,0.036628146,0.047119103,-0.006403773,-0.028790394,0.03508422,-0.035391502,-0.015171729,0.021093136,-0.019160157,-0.059746925,-0.008112527,-0.051048975,0.003341067,-0.016135575,0.04491751,0.01354164,-0.03126301,0.07070219,0.034385543,0.048944037,0.0018758753,0.041873284,-0.012872889,-0.022869112,0.0018267266,-0.0050699078,-0.07005668,0.020033918,-0.028498834,0.031638194,-0.058126535,-0.017712133,0.068077475,-0.02029074,-0.047950678,-0.04675636,0.050334666,-0.0024913254,-0.013982385,-0.022104656,-0.06612073,0.012561908,-0.17287008,0.0523788,-0.05332728,0.019105058,0.05551777,-0.059210528,-0.009751553,-0.043756936,-0.04617171,0.092215754,-0.076849066,-0.031597394,0.0008626233,-0.08342391,-0.08000407,0.07150782,-0.018584339,-0.05766767,-0.026783206,0.06978553,-0.09406246,0.072079636,-0.0759532,0.04335194,-0.012994455,-0.09956749,-0.080183856,-0.0019047316,0.006879461,-0.032796726,-0.00095101213,-0.060364127,-0.058500316,0.07067647,0.029502971,0.086220644,-0.035880774,-0.028554333,0.03826715,-0.01983061,0.0049048266,0.069384016,0.030873142,-0.014300066,0.04715245,0.016076919,0.033329174,0.028677763,0.054996736,-0.025067098,-0.0057405,-0.024194008,0.05114718,0.008959668,-0.0119864,-0.008156003,0.10181796,-0.048224285,-0.02979685,-0.019413974,-0.023437986,-0.030333335,0.09813722,0.07414934,0.060097218,0.03428037,-0.0379652,-0.011399807,0.06178811,-0.029688254,0.13790916,-0.035272855,-0.110823505,0.0008779676,-0.0734064,0.09034835,-0.027525527,0.0011560118,0.029533548,-0.01010452,0.0049886163,-0.088417165,1.2307273e-33,0.04994779,-0.008333545,0.038860895,0.0517529,-0.005879857,0.045682438,-0.1129945,0.0074412287,-0.018974846,-0.04374034,-0.114782274,-0.0069574546,0.038502418,0.074055605,-0.039014015,-0.089023955,-0.04219123,-0.027206874,0.10231344,0.018541671,0.007442646,0.08565361,-0.045499552,0.012223636,0.0234875,0.027457006,-0.017692016,-0.006567821,0.010442455,0.010345304,0.026487276,-0.12885141,-0.07008487,-0.0008068201,0.06821699,-0.04700711,-0.023637677,-0.03580668,0.022114044,0.0865887,-0.070182234,0.020686217,-0.00974863,-0.065010086,0.08772662,-0.059482183,-0.017893542,0.0877164,-0.027988309,0.10978793,0.05227703,-0.014862787,0.046350166,-0.041722126,-0.059970245,0.08519753,-0.055607628,0.03810164,0.05556132,0.11208206,0.009227151,0.025621481,0.036491092,0.038691707,-0.020492766,0.02350825,-0.08137471,-0.039256006,0.01448935,0.076644145,-0.017717794,0.005311247,0.07788484,-0.01840803,0.039252937,-0.018768474,-0.046196252,0.060211048,-0.026879482,0.013157484,-0.05463471,0.0084140925,-0.04115311,-0.029614497,-0.04037387,0.052877657,-0.029487953,0.037451416,0.003913519,0.07930073,0.010154107,-0.04497912,-0.0497348,-0.010364935,0.044193618,-2.967227e-33,0.08461675,-0.0817215,0.047616012,-0.06806078,0.0053597423,0.09393615,0.058877803,-0.034102418,0.0028154228,0.0183241,0.090738475,0.025587864,0.04950078,-0.026442036,0.06223135,-0.0688632,-0.10825621,0.02099966,-0.03388657,0.042688407,0.032812446,0.07740223,0.029589023,0.028037112,0.055779073,-0.0109506035,-0.011780251,0.021403672,0.047599297,0.011775804,-0.045811538,0.021400923,-0.059450228,-0.04223865,-0.009425009,0.08470526,-0.00604654,-0.0015890938,-0.03987427,0.06125674,-0.04528136,0.01158582,-0.02744386,0.036115747,0.09677797,0.01429389,-0.06617314,-0.01856906,0.018799704,-0.047583096,0.024018006,0.045055036,-0.037443135,0.008158113,0.049046867,0.058587775,-0.040571872,0.050930392,0.09404116,0.03496844,0.03932362,-0.018102184,0.07405181,-0.039346103,0.031835683,0.022223787,-0.004875103,0.02190501,0.02349444,0.027475515,0.15437995,-0.0017566077,0.038254827,0.057249002,0.014047084,-0.010374605,-0.08077593,-0.047376413,-0.03422453,-0.0674925,-0.021441631,0.027712645,0.01865237,-0.057790726,0.0044519245,-0.08687024,-0.0031897412,0.083605945,-0.02036813,0.007669173,-0.026184795,-0.03713971,-0.09678787,0.08093118,-0.05288423,-4.7796224e-08,-0.022521177,-0.06524728,0.032981347,-0.035610415,0.046939753,0.05347967,0.014772349,-0.0015065037,0.036928598,-0.008270298,0.056572806,0.08015066,-0.01415653,0.04961823,0.007924796,-0.0034425259,-0.03812774,0.02383167,-0.029982746,-0.02642327,-0.04372999,-0.0049651195,-0.14685236,0.048294652,-0.015236018,-0.055351418,0.014919028,0.06921167,0.012161098,-0.107302554,0.0067422464,0.032554764,0.03954776,-0.047543958,-0.088260256,0.01125057,-0.036755428,0.020377427,-0.08762548,-0.05324484,-0.041960824,-0.11815818,0.050311968,-0.01710773,0.02399792,0.011210198,0.0077582323,-0.009974421,-0.035254236,0.027529748,0.056919206,-0.014980975,-0.030104833,-0.04168544,-0.038911954,0.013452349,-0.008455843,-0.088877715,-0.016400915,-0.04510387,0.05341674,-0.013320085,0.13751347,-0.010379039 +1.4.1.22,The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2].,384,0.99999994,-0.064543635,-0.028827522,-0.0029871156,0.016834576,0.10440188,-0.00781468,0.013306995,0.044623774,0.029426964,-0.026729895,0.028789707,0.020287279,-0.04176491,0.050561134,-0.046985123,0.096178986,-0.04461144,0.036146805,0.016535746,-0.047390558,0.13081613,-0.009510083,0.051078137,-0.011098629,0.026725572,-0.0055316295,0.05173709,0.063966215,0.05614187,-0.051147446,-0.041892536,-0.029153043,0.037538324,-0.011055693,0.0013131663,0.08219058,-0.039035656,-0.10078472,-0.05409344,-0.02599529,0.08344269,0.06343513,-0.031432047,-0.023218537,-0.05666209,-0.030590063,0.0305753,-0.020845491,0.00642841,0.052803367,-0.042212132,-0.021759298,-0.014367871,-0.016558336,0.051517475,0.027889263,-0.12100501,-0.0089112995,0.0030205953,-0.003726968,0.017559905,0.004731115,0.0028387008,0.0012351727,0.050519668,-0.0059287627,0.035607673,-0.022970093,0.014206286,-0.102539584,-0.029630324,-0.03792669,-0.0012899247,0.038462043,-0.032741565,0.0171255,-0.018456798,-0.04584821,0.035321593,0.027113996,-0.014887754,-0.034497384,-0.003693591,0.04606453,0.040368143,0.0027873549,-0.014417058,0.03223464,0.018117692,-0.015469754,0.00086986617,-0.06283667,-0.065958984,0.004391552,-0.030703431,0.042976912,0.019881828,0.012059592,-0.063727416,0.013974548,0.010150466,0.08664765,0.016437685,-0.063661635,-0.041469414,-0.044436764,0.0313644,0.030262936,-0.034834508,-0.0027487085,0.009993262,0.008903625,0.06316453,0.035397794,0.005570826,0.08667217,-0.033371493,-0.025646918,-0.024082292,0.02139271,0.0324107,-0.0060251914,-0.074227,0.08130206,-0.06614317,0.030243712,-0.12731019,-3.675263e-33,0.021001888,0.028534973,0.0101434775,0.019052872,-0.007846292,-0.041258108,-0.06319067,0.019782204,-0.07648826,0.0040370016,-0.034833696,-0.084685,0.103530146,-0.019407678,-0.024988621,-0.08083695,0.03903117,-0.03681046,0.08697621,0.051024016,0.007094157,0.089102186,-0.07834238,0.06402353,-0.009599449,0.05869297,-0.06651713,0.005735696,0.057259303,0.012011709,-0.012701027,-0.054859824,-0.12524572,0.00241149,0.017641451,-0.07255123,-0.0328935,-0.04653745,0.04209848,-0.014625363,-0.045789726,-0.04193537,-0.04883943,0.019885896,0.063180804,-0.054049455,-0.026417438,0.029785747,0.05365071,0.015828159,0.07986154,-0.08869004,0.067729674,-0.002241317,-0.09395767,-0.00096966285,-0.063182265,-0.046228778,0.010844482,0.077718414,0.053456992,-0.03750226,-0.076061055,0.038189955,-0.011971228,0.06471562,-0.09820444,-0.091877386,-0.029464701,0.11111211,-0.057940625,-0.0045462674,-0.021308439,0.017564807,-0.0044046906,-0.022370994,-0.024124308,0.0073931064,0.03102152,0.07015477,-0.02773924,-0.015799096,0.006921415,-0.012433199,-0.10198284,-0.03217706,-0.01986532,0.008177953,0.01823818,0.03656758,0.059372295,-0.07192749,-0.044581152,0.0820964,-0.021124914,3.5132103e-34,0.10054672,-0.08260177,0.08267287,-0.08348918,-0.051948223,0.11317824,0.07947126,-0.027603282,0.056493934,-0.026175238,0.046838075,-0.05356582,-0.01768703,-0.07607089,0.023070743,0.052707866,-0.020636437,0.04987669,-0.020745499,0.0213833,-0.04338221,0.1141194,0.06911751,0.025981033,0.00013471466,0.020978432,0.00022442217,0.035233393,0.003137925,0.105900176,-0.077211834,-0.015298978,-0.021064594,-0.018773466,-0.031324737,0.0518706,0.017919466,0.00396289,-0.055161677,-0.025178159,0.033728216,0.059695143,0.014371579,0.13470936,0.022725588,0.09128947,0.017453052,0.00041259773,-0.07887933,-0.08248027,-0.019163424,-0.0028078498,0.0314705,-0.0088717025,-0.040509652,0.06837295,-0.021670068,-0.019224685,0.0068601966,-0.0073390943,-0.006860466,-0.016570484,0.0071038157,0.026320465,0.021458479,0.089727625,-0.02843585,0.016952155,0.024681496,0.0043936963,0.014717078,0.060260866,-0.025342414,0.043436635,0.014791034,0.041428722,-0.12878923,-0.00018292165,0.0049025808,-0.075046904,-0.072481744,0.08901099,-0.052158415,-0.07658161,-0.02525844,-0.058228724,0.026370892,0.10797424,0.046733785,-0.042644076,-0.035386033,-0.033426028,-0.078071564,0.0668049,0.025503915,-3.1394364e-08,0.0032969925,-0.036529597,0.053650416,-0.06263749,-0.033397987,0.06399167,0.05568409,0.03351258,0.022184646,0.033467427,-0.021398762,0.10640007,-0.008219901,-0.04814164,0.026607001,0.03811519,-0.042272616,0.024784578,-0.01821943,-0.05042054,0.056065075,-0.027560145,-0.07106844,0.13113058,-0.010371337,-0.05721694,-0.01940128,0.064724326,-0.009085712,-0.053107988,0.041414883,-0.01005467,-0.022674404,-0.0036417986,-0.06357422,0.026768906,-0.017086739,-0.073723756,-0.019170398,0.050345886,0.007847344,-0.04316099,0.00216995,-0.021562176,0.02163835,0.059634097,0.0019002891,-0.049355328,0.036332816,0.030340651,0.07272087,-0.01538907,-0.09791317,-0.013922883,-0.16482408,-0.10431327,-0.015918175,-0.09483962,-0.03232134,-0.08004926,0.0351124,-0.0067504183,0.15174718,-0.05491176 +3.2.1.160,"The enzyme from Chrysosporium lucknowense is an endoglucanase, i.e., acquires the specificity of EC 3.2.1.151, xyloglucan-specific endo-beta-1,4-glucanase, when it acts on linear substrates without bulky substituents on the polymeric backbone (e.g. carboxymethylcellulose). However, it switches to an exoglucanase mode of action when bulky side chains are present (as in the case of xyloglucan). The enzyme can also act on barley beta-glucan, but more slowly.",384,1.0,0.04153645,-0.06227977,-0.07394942,0.004647204,0.040623568,0.014172198,-0.015228006,0.0039052411,0.045467377,-0.020798894,0.05344303,0.02355058,-0.045417562,0.054976862,-0.064981654,0.021051519,-0.028513655,0.011858625,-0.029208248,-0.038283914,0.11153997,-0.04941541,-0.02240274,0.024038125,0.014281332,-0.07948087,-0.06538881,-0.10661984,-0.054109816,-0.12583025,-0.016714554,0.016024072,0.013320136,-0.012845912,0.0006664123,0.12175352,-0.04939224,-0.08407281,0.014285229,-0.040746555,0.047618907,-0.0392826,-0.05228634,0.026682606,-0.086348556,-0.013808978,0.008458772,0.015491866,0.025326505,0.0062966133,0.023948057,-0.1066159,0.008469045,-0.017074427,0.042827398,-0.012128251,-0.039105736,-0.010164657,0.022556005,0.058566235,-0.011184864,0.059278917,-0.018147338,0.020326855,-0.029669393,-0.05852337,0.014371317,-0.054809064,0.015805874,-0.01458655,-0.039016966,-0.026685141,-0.040018514,-0.0053621274,0.06115717,0.038615014,-0.001443106,-0.017729662,0.041346315,-0.032491487,0.048702877,0.020488013,0.0629357,0.01058129,-0.036933508,-0.0359716,0.011684692,0.03228974,0.01635966,0.017435007,0.084707625,-0.019040035,-0.01570038,0.046911232,0.017677128,0.011924815,0.087448426,-0.012519685,0.03633061,-0.11525307,0.015800726,-0.0075144405,0.058187317,-0.04906178,-0.0037567979,-0.01653392,-0.04354316,0.056122918,0.05755418,-0.045781843,-0.027158733,-0.021214582,0.05400803,-0.010501395,-0.054845214,0.08628679,0.027937463,-0.07038767,-0.06986072,0.003405015,0.019355776,-0.013029708,0.021146739,0.0065827593,-0.025501426,0.075797334,-0.06105861,1.8069291e-33,-0.022720601,0.022696668,-0.035741292,-0.030668532,0.00879902,-0.104562156,-0.05638449,0.008116979,-0.08582038,0.02034123,-0.04286678,-0.009135111,-0.061500624,0.10194995,0.012322954,0.045461822,-0.016206283,-0.011540665,0.0057252184,0.060474,-0.007621345,0.023459377,-0.07160424,-0.008312762,0.0578176,0.06338459,0.020313226,-0.004313639,0.042934906,-0.015993094,0.101376995,-0.04660957,-0.059189282,0.1342303,0.03650523,0.06503678,0.008765997,-0.060911216,-0.029607894,0.021136211,0.032627437,0.043741886,0.0373846,-0.059194807,0.024677355,-0.05061711,-0.04089949,0.049661584,0.01079289,0.061892204,0.10434831,0.080176495,0.063842714,0.012019491,0.04751018,0.036191113,-0.016623994,-0.0068855565,0.020368198,0.024759334,-0.041169398,0.033604957,-0.03400052,-0.02624796,-0.0173963,0.0011389777,-0.07470149,-0.029606547,-0.051786315,0.061026324,-0.061469596,-0.035973262,0.019189276,0.009890148,0.037966765,0.019462401,-0.076833844,-0.020353803,0.030375602,0.011221147,0.062161397,0.0062151696,0.03447798,-0.03140353,-0.095915236,-0.020949155,-0.035525754,0.04502787,-0.011881655,0.09486913,-0.016500583,-0.01706859,-0.006333871,0.101146884,0.0030259013,-2.8790922e-33,0.109643705,-0.10214383,0.064338125,-0.018484132,-0.020098234,0.07998699,0.04212187,-0.032588314,0.05094633,0.05947825,0.10099046,0.06433384,-0.0006592821,0.012593452,0.027436642,0.06970105,-0.03555274,0.07601071,-0.053202834,-0.022784453,-0.08108309,0.1070108,-0.0008313152,0.0053715897,0.06309017,-0.03668035,0.0042780438,0.04988957,-0.0110904565,-0.04344575,-0.018248709,-0.07654423,0.0069348966,0.0076340926,-0.06455999,0.009370043,-0.058624722,-0.0040479284,0.08510081,0.03431999,0.0010308636,0.019917674,0.01700476,-0.007527205,0.033902217,0.06133728,-0.0758308,0.010393455,0.06466845,0.007065945,0.010042799,0.059086632,0.019443188,0.037230458,0.03980639,0.035277743,0.026268762,0.0074986233,-0.08723777,-0.058024596,-0.041127186,-0.0157943,0.050617594,-0.051136162,0.051330812,0.0024614912,-0.0706962,-0.022253226,0.015797872,-0.027684499,0.103736214,-0.007814911,-0.032194067,0.033601638,-0.007159303,0.030971102,-0.06524391,-0.06389182,-0.005355719,-0.057286993,0.03774408,0.035996974,0.09325394,-0.054222275,0.06067742,-0.06584536,-0.0049846014,0.1005337,0.024717813,0.00012400915,0.009449731,-0.04319096,-0.012678093,-0.0025062468,0.12874024,-4.3545406e-08,-0.060325705,-0.0039530625,-0.029635912,-0.13516088,-0.004043416,-0.0023355347,0.05696864,0.03021683,-0.008104979,-0.026807044,-0.02337392,0.097358495,-0.024942419,0.0840371,0.00034850303,-0.041403443,0.015127221,0.0074613136,0.015385124,-0.013899549,-0.1378397,-0.011066784,-0.12821127,0.03926511,-0.065322205,-0.06865362,0.08386631,0.061582677,0.0060226712,-0.015281661,-0.036618352,0.06934184,-0.07322915,-0.027239127,-0.088805795,0.046141848,-0.014955984,0.0039111963,-0.039785855,0.09159177,0.09500367,-0.07828841,-0.012315141,-0.014363099,-0.06245296,-0.026606215,0.0046446603,-0.025603445,0.00790425,0.07021663,0.124173366,-0.06169186,-0.053421155,-0.08571346,-0.049670964,-0.009210865,0.0071738027,-0.03354772,0.029784309,-0.066475175,-0.019877404,-0.052852433,0.20464727,-0.035165824 +3.4.22.55,"Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) [6]. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6]. Two forms of caspase-2 with antagonistic effects exist: caspase-2L induces programmed cell death and caspase-2S suppresses cell death [2,3,5]. Caspase-2 is activated by caspase-3 (EC 3.4.22.56), or by a caspase-3-like protease. Activation involves cleavage of the N-terminal prodomain, followed by self-proteolysis between the large and small subunits of pro-caspase-2 and further proteolysis into smaller fragments [3]. Proteolysis occurs at Asp residues and the preferred substrate for this enzyme is a pentapeptide rather than a tetrapeptide [5]. Apart from itself, the enzyme can cleave golgin-16, which is present in the Golgi complex and has a cleavage site that is unique for caspase-2 [4,5]. alphaII-Spectrin, a component of the membrane cytoskeleton, is a substrate of the large isoform of pro-caspase-2 (caspase-2L) but not of the short isoform (caspase-2S). Belongs in peptidase family C14.",384,0.99999994,-0.011763999,-0.10249031,-0.024694553,0.002093156,0.06711174,-0.042015996,-0.050786454,0.118959524,0.09860527,0.039358966,0.0032088326,-0.029538391,-0.051872212,0.06408837,0.04979999,0.014818018,-0.014379194,0.051861614,-0.008330286,-0.055888467,0.079967014,-0.026576167,0.0018013995,0.00072663877,0.005343845,-0.008148772,0.012479025,-0.020674238,-0.017773515,-0.037101176,-0.042642467,-0.09375654,-0.060032636,-0.038987286,0.010438875,0.027976612,-0.0437925,-0.015871381,-0.032138877,-0.08362056,0.06310245,-0.005365343,0.013510793,-0.05090619,0.06923505,0.013631849,-0.017492084,0.048092775,0.002748954,0.040106725,-0.0534084,-0.044803318,0.027170895,0.047847502,-0.07405776,-0.013776868,-0.013976165,0.032168977,0.061882384,-0.020620538,-0.040377263,-0.0059123533,0.028437588,0.010228496,0.0053134304,-0.049621705,-0.0020201686,-0.019011714,-0.053740535,0.06742258,-0.014407692,-0.03268791,0.007532543,0.08811245,0.053058874,0.08088932,0.01302679,-0.020507608,0.008725109,-0.09601437,0.13053863,0.012967598,0.10519821,0.10962106,-0.019757913,-0.0018036311,-0.026227994,0.02144293,0.034291912,0.04476925,-0.0015383218,0.025742162,-0.0042520175,0.048331756,-0.044033926,0.06634229,-0.050479937,0.04567033,-0.07533705,-0.006292484,-0.031912427,0.0034917635,-0.04844168,-0.08190447,0.074743345,0.017912539,-0.08001981,0.041798446,0.071002975,0.007738975,0.052959453,-0.06083928,-0.010615362,-0.03886875,0.032333415,0.15680036,-0.003486531,-0.01747555,0.084419124,0.0014826872,0.038780306,-0.070215136,-0.037240446,-0.03001819,-0.06334369,0.0583549,-0.013235472,3.5760445e-33,0.011452232,-0.013396338,0.017290218,0.078863546,0.03292023,-0.09649902,-0.0017685354,-0.049192213,-0.04383824,-0.0023659826,0.02682025,-0.08860801,0.034380034,0.018961385,-0.0018643704,-0.012093733,-0.019829515,-0.016472287,-0.026462361,-0.051804963,0.0054174364,0.02795059,-0.014699297,0.030147078,0.050965987,0.053180326,-0.057040643,0.07172581,-0.023507716,-0.0074399575,0.018020887,-0.044248402,-0.027177347,0.030787282,0.072008856,-0.03613341,-0.01684563,-0.049230695,-0.0027626774,0.08239806,-0.04734446,0.021898098,-0.03940824,-0.057488356,0.08895252,-0.16661625,0.054318827,0.055029653,-0.051677212,0.04998068,0.100706555,-0.013650065,0.029930795,0.06962644,-0.026228199,0.01896331,-0.05826659,0.021794315,0.04388097,-0.039288193,0.047113165,-0.043364983,-0.053733192,0.07198872,-0.04490207,0.043727268,-0.041138258,-0.11572957,-0.021562915,0.029751837,0.008435089,-0.015489237,0.0046686213,-0.010597998,0.006558846,-0.03233456,0.03834639,0.06525807,-0.032803517,0.042820305,-0.026592331,0.008320521,-0.10795897,0.05937771,-0.038180012,0.015258958,0.020316562,-0.0773739,-0.040260203,-0.046506304,0.07827318,-0.0075795287,-0.07943354,0.08909211,0.030275663,-5.008369e-33,0.024104027,-0.028901087,0.04765056,-0.064285286,-0.118459746,0.002889729,0.022915892,-0.074098885,0.061372235,-0.07878462,-0.016962748,-0.0024073739,0.005320424,0.049465574,-0.0045329463,-0.029670697,-0.034393992,0.03758213,0.0015979703,-0.00014723121,0.094606444,0.14084038,0.0010999856,0.14477722,0.06435895,-0.065294005,-0.01494163,0.012891262,0.061836205,0.04270315,0.029737685,0.059788007,0.022378787,0.008385886,-0.0025974645,-0.024927564,0.039371338,-0.04635261,0.029600354,-0.0656266,0.013292341,0.022208074,0.019532628,0.02593657,0.030228458,0.019857436,0.0056326734,0.072299436,-0.035884663,-0.003875594,-0.086212,-0.040077772,-0.05230438,0.05463746,-0.0013210553,0.009460176,0.0024699494,0.0019015016,0.021504132,-0.043185182,-0.05329159,-0.00742997,0.04696496,0.026030166,0.10418999,0.050389763,-0.048311807,0.039829187,-0.002249578,0.006584132,0.04962913,0.014018244,-0.10561198,-0.007041817,-0.05420695,-0.034673695,-0.037229415,-0.0026849047,0.0104582505,-0.06881343,-0.05551731,0.0012469622,0.045175966,-0.032135237,-0.020455284,0.015198184,-0.01722252,0.13415802,-0.040900957,0.03635317,-0.04507413,-0.086437516,0.029878672,0.06601262,-0.07159575,-5.474559e-08,0.05339319,0.04394561,-0.0068312297,-0.07522319,-0.08109109,-0.06219181,-0.0162243,0.034971304,0.021796608,-0.014328833,-0.001374705,0.104379125,-0.0005183119,-0.06164569,0.01626698,0.104684465,0.021218643,-0.014802593,-0.025779717,-0.026280122,-0.013061123,-0.09923169,0.0031604937,-0.028578665,0.020992253,-0.033599272,0.024123583,0.02271045,0.021425322,-0.06182834,-0.0773275,-0.02851872,0.05333464,-0.08248873,0.047203716,0.07962832,-0.04802713,-0.08070172,-0.02119244,0.07290036,0.033336822,-0.02477791,-0.0028318,-0.071219526,-0.0029257222,0.038656957,0.04413194,-0.030065548,-0.030398991,-0.062036093,-0.1061315,-0.087260984,-0.043061115,-0.0139026055,-0.0893282,0.0047974586,-0.0319887,0.031290773,0.094635844,-0.028102497,0.065700024,0.08987376,0.07063118,-0.05993399 +3.4.22.56,"Caspase-3 is an effector/executioner caspase, as are caspase-6 (EC 3.4.22.59) and caspase-7 (EC 3.4.22.60) [5]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [3,5]. Procaspase-3 can be activated by caspase-1 (EC 3.4.22.36), caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) as well as by the serine protease granzyme B [1]. Caspase-3 can activate procaspase-2 (EC 3.4.22.55) [2]. Activation occurs by inter-domain cleavage followed by removal of the N-terminal prodomain [6]. Although Asp-Glu-(Val/Ile)-Asp is thought to be the preferred cleavage sequence, the enzyme can accommodate different residues at P2 and P3 of the substrate [4]. Like caspase-2, a hydrophobic residue at P5 of caspase-3 leads to more efficient hydrolysis, e.g. (Val/Leu)-Asp-Val-Ala-Asp! is a better substrate than Asp-Val-Ala-Asp! . This is not the case for caspase-7 [4]. Belongs in peptidase family C14.",384,1.0,-0.0115654655,-0.12804948,-0.018251324,-0.063747674,0.036531825,-0.023807777,0.017838325,0.08858113,0.064913735,0.04321254,0.0069870003,0.038566593,-0.046628136,0.06524396,0.05149574,0.040534984,-0.041270904,0.08870253,0.008487011,-0.0640696,0.09551516,-0.039622616,-0.01525409,0.0156697,0.02590019,-0.020001357,-0.002305811,-0.008598439,-0.06405789,-0.05683912,-0.07843768,-0.069992475,-0.016444976,-0.031690933,0.04096522,0.064092815,-0.05769609,0.0009875348,-0.031320546,-0.07601954,0.10485485,-0.038714968,-0.009441493,-0.06686533,0.0083835805,0.012480277,-0.018616863,0.05200429,0.004155247,0.049714793,-0.028905652,-0.059603915,0.0045277374,-0.010440771,-0.09682775,-0.013479944,-0.009324445,0.018795975,0.06339228,-0.012013092,-0.13014334,-0.023831628,0.017710032,-0.0053852038,0.020390352,0.003325718,0.057673536,-0.06737277,-0.06813185,0.054188523,-0.0110042365,-0.03920616,-0.02032764,0.07727244,0.0130032115,0.09552341,-0.011346297,-0.01913779,-0.01265042,-0.09574537,0.1152762,0.037125472,0.024560414,0.10475048,0.02941908,0.007843664,-0.008646128,0.0706205,0.009142434,0.011577625,0.039611407,-0.039586227,0.0034994574,0.079321526,-0.0155809475,0.044995416,-0.040790334,-0.00987261,-0.03448584,-0.032960963,-0.037221573,-0.0011055066,0.017599305,-0.091093294,0.06370852,0.060842887,-0.06767488,0.07867326,0.03966386,-0.011414518,-0.005141926,-0.010790804,0.0324111,-0.037426207,0.023780076,0.10642331,0.006100116,-0.02703108,0.05127312,-0.04343932,0.014574929,-0.048902746,0.016535172,0.009581597,-0.038476814,0.015824031,-0.02120979,2.4370257e-33,0.047217216,-0.01643876,0.02847168,0.052700702,0.017725602,-0.011312544,0.00096753286,-0.07680192,-0.03771347,-0.0038523835,-0.052371386,-0.06761158,0.03200409,-0.0059024408,0.011249084,0.03949728,0.008664725,-0.021757547,0.0014942787,-0.020923624,-0.009684546,0.038156595,-0.039590597,0.07105269,-0.017928729,0.053380843,-0.046805993,0.050206207,-0.0026363214,-0.017223997,-0.019494904,-0.05206273,-0.03334159,0.09649827,0.04173539,-0.0013586745,-0.023609333,-0.09581764,-0.010041007,0.084298946,-0.06407499,0.01474708,-0.0067117256,-0.034303784,0.094453424,-0.1235269,-0.0009904985,0.05771483,-0.060591046,0.08156662,0.08635253,-0.021518983,0.08625607,0.05402837,-0.08709278,-0.019152723,-0.06969139,0.0336837,0.052655466,0.025343532,0.08698484,-0.021353915,-0.03877139,0.04729705,-0.027520742,0.07211218,-0.05110419,-0.06272553,-0.030976161,0.05168368,0.03511946,-0.031258404,-0.0010188522,0.03999214,0.029095829,-0.022995286,0.007844633,0.036058627,-0.06010769,0.053230684,-0.026978424,-0.0082173785,-0.091614835,0.07576681,-0.068253525,0.05117817,0.02576019,-0.052523285,-0.03636671,-0.029119141,0.10553018,-0.011230404,-0.0322844,0.12191958,-0.039033223,-3.7339574e-33,0.03615894,-0.05991118,0.05716914,-0.0757952,-0.10800589,0.022563955,0.051681917,-0.06907729,0.04213628,-0.08993659,-0.026118068,-0.053049903,0.048936315,-0.07750736,-0.034987926,0.027859304,-0.021774279,0.023827076,-0.020614875,0.053164493,0.089926966,0.09607838,0.02010032,0.12229784,0.07223309,-0.05792052,-0.013341271,0.0256332,0.066731095,0.018823888,-0.011129725,0.111758456,0.014601824,-0.034888048,-0.004292845,-0.041939497,0.03532772,-0.04062485,0.04821195,-0.06335157,-0.038911376,0.019331688,0.037366077,0.05742992,0.07832316,0.100758456,-0.03395903,0.039456643,0.008200843,0.009786421,-0.070382886,-0.010052296,0.0075326944,0.026734,0.014031452,0.00828272,0.027785664,-0.0031917817,-0.054334793,0.0073189666,-0.028031671,-0.0052404394,0.027554328,0.049024742,0.09867069,0.10763797,-0.029584108,-0.019410359,-0.013198578,-0.009764183,0.025267955,-0.026571438,-0.08402959,-0.02608567,7.13179e-05,-0.034941424,-0.06333243,-0.016281815,-0.004278872,-0.05827081,-0.036175683,0.01861945,0.0037492083,-0.03255838,-0.03436712,0.02313409,0.0044032168,0.090801746,-0.0037361763,0.04217268,-0.018208427,-0.036742125,-0.011789067,0.07616037,-0.04908016,-5.631094e-08,0.11547828,0.032019086,-0.038742445,-0.10770936,-0.06049978,-0.0394916,-0.04617399,0.029871454,0.018510722,-0.07653527,-0.016411088,0.07363614,-0.019594092,-0.007888938,0.036251057,0.037545867,0.001163913,-0.03308422,-0.019369012,-0.043083336,-0.019186895,-0.086405255,-0.014548579,0.033630826,0.030614223,-0.027836725,0.03714058,0.005355821,0.050592862,-0.038659383,-0.06863029,-0.014139731,0.02048754,-0.11612408,0.052348163,0.12127506,-0.042392176,-0.045919687,0.033023674,0.106580585,0.029505068,-0.067504376,0.008889709,-0.048855104,0.025277797,0.012680503,-0.01659603,-0.015755937,0.016267868,-0.034635764,-0.0074814786,-0.05345885,-0.05615602,-0.07116263,-0.09592312,0.015576739,-0.018177127,-0.055966366,0.11741019,-0.070243716,0.05845622,-0.006239692,0.09148908,-0.081449695 +3.4.22.57," This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [3,5,6]. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but, unlike caspase-1, it is very inefficient at generating mature interleukin-1beta (IL-1beta) from pro-IL-1beta [1,4]. Both this enzyme and caspase-5 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17) [3]. The caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO can also inhibit this enzyme, but more slowly [4]. Belongs in peptidase family C14.",384,1.0,-0.08536457,-0.105847485,-0.046091095,0.0037949204,0.036241062,-0.051468737,-0.05455075,0.048454247,0.05920738,0.027632521,0.008908303,0.005619444,-0.01167481,0.06920547,0.04149163,0.01443576,0.012436621,0.012971843,-0.024173312,-0.058920905,0.020812957,-0.0733127,0.036663007,0.0134419175,0.0040653255,-0.01067304,0.0073068477,-0.033553045,-0.044358682,-0.08576304,-0.030505246,-0.093556836,0.0214965,-0.029663099,-0.002765718,0.013738697,-0.14168267,0.004734995,0.046443265,-0.036167026,0.072761714,-0.020510059,0.03467099,-0.11005124,0.06680151,-0.06139029,-0.020204684,0.06816996,0.028506286,0.097861074,-0.013647382,0.019037174,0.02878107,0.051292337,-0.05664866,0.026101466,-0.045897566,0.0031588601,0.053573485,-0.0066178855,-0.06030146,-0.029948454,0.058810882,-0.0010046302,-0.034893617,-0.07981452,0.021697985,-0.017466774,-0.07008116,-0.009064325,-0.0022977793,-0.044014167,-0.035792563,0.1025544,0.072766274,0.111181125,0.024931652,-0.02965854,0.049652096,-0.056239348,0.0919426,0.053280402,0.054567955,0.09174803,0.03177978,0.016130794,0.0072484002,0.04334453,0.0052184593,0.023898235,0.010355359,-0.028342012,-0.008867787,0.021739641,0.019094875,0.02372785,-0.03924732,0.051516924,-0.08420769,-0.021837436,-0.024951376,0.040431917,-0.0096151745,-0.08878081,-0.0073576085,0.0198028,-0.021870945,0.04814035,0.04590438,0.010327331,-0.0036408745,-0.06990831,0.01766874,-0.08000722,0.024529539,0.15661523,-0.010016522,-0.017690605,0.09733663,-0.004486089,0.012935558,-0.073683806,-0.008286918,0.012467198,-0.040559076,0.04789689,-0.0024264546,1.2146964e-33,0.010329249,0.0033367048,-0.046880763,0.060165286,0.06998154,-0.05748011,0.02040395,0.017524224,-0.07780593,-0.017915713,0.0015795749,-0.026287636,0.043527372,-0.0331728,0.011277698,0.027945459,-0.0057316734,-0.026752433,-0.06943277,-0.036569946,0.010376183,0.0025864453,-0.0348641,-0.00759104,0.014582845,0.026298728,-0.025610076,0.08292742,-0.0053062504,-0.005216796,-0.06421052,-0.011305316,-0.063856624,0.011903049,0.02017486,-0.024714682,0.008631046,-0.034410845,-0.042548183,0.06054478,-0.045411,0.036603823,-0.054710425,-0.03756653,0.07497811,-0.1664822,0.020929964,0.039983902,-0.08078533,0.081468895,0.089674346,0.026775971,0.052157935,0.05963194,-0.021856692,0.005767921,-0.062212173,0.03586579,0.06458025,0.010772701,0.06706974,-0.04809173,-0.04758608,0.0877102,-0.009320198,0.05802182,-0.024807533,-0.03436698,-0.080710076,0.059762098,0.034085713,-0.043401286,-0.05765636,-0.016851783,0.022728767,-0.0069858707,0.09183901,0.05864713,-0.057234727,-0.023452071,-0.06326997,-0.0046699005,-0.013067029,0.12492848,-0.064645156,-0.0120397145,0.011728203,-0.06851823,-0.010800625,-0.08164109,0.094988406,-0.023103759,-0.024195416,0.108853474,-0.0034000664,-1.9173808e-33,0.03917624,-0.055157088,0.05915093,-0.150377,-0.1414486,0.041394066,0.080931716,-0.062110104,0.026423708,-0.06149544,-0.030109746,-0.013447501,0.0063878954,-0.044209972,0.0071937474,-0.0103232935,-0.02191043,0.08462642,-0.03448678,0.05779278,0.12137737,0.12590785,-0.017928101,0.14041592,0.030382037,-0.0034462167,0.0063655805,0.012804046,0.042304493,0.072588876,-0.043796387,0.015455445,0.01115935,-0.0346002,-0.040147267,-0.003659156,0.013516427,-0.023186529,0.004864751,-0.0036619399,-0.046538457,0.017544338,-0.012185193,0.025768708,0.0337879,0.05220354,0.025645684,0.02328285,0.032658625,0.011206071,-0.043622237,-0.030348472,0.013226303,0.018811196,0.012754775,0.021393461,0.056292895,-0.014644923,-0.016767154,-0.072227366,-0.046574023,0.048036594,0.046817385,0.005936269,0.08726333,0.03975738,-0.03750505,-0.014852187,-0.024708116,0.036980953,0.031563044,0.017905258,-0.07177968,-0.011702207,0.0034309218,0.027110828,-0.0052379924,-0.021162046,0.013836066,-0.06607171,-0.042930484,-0.0001721339,-0.0049431417,-0.081659615,0.0033113894,0.03610115,0.035518106,0.071758814,-0.014074449,0.12032606,-0.047854904,-0.04708898,-0.015751451,0.086474635,-0.07624377,-5.3023165e-08,0.10020657,0.030075185,-0.028928952,-0.032484867,-0.08705485,0.007647626,-0.06821152,-0.024266548,0.03251982,-0.030557958,-0.02979339,0.114494085,0.0091589345,0.0051916987,0.01443054,0.061138153,0.030200062,0.011321275,-0.010965695,-0.022302005,0.007930736,-0.047160204,0.028983265,-0.052566487,0.03439731,-0.08152921,-0.020368883,0.037496842,0.04585041,-0.05044332,-0.100572765,-0.014602628,0.058599386,-0.082639985,0.073434055,0.052473184,-0.033670343,-0.036820143,-0.051996034,0.05425735,0.07659208,-0.040938567,0.0064460435,-0.073787555,0.021145277,0.03007873,-0.012663934,-0.053263593,-0.012925435,-0.007435829,-0.09009417,-0.066067986,-0.025559198,-0.024976697,-0.06397981,0.018769821,-0.051248044,-0.040465966,0.0753608,-0.058010153,0.019277388,0.078330725,0.09142933,-0.037392046 +3.4.22.58,"This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [3,5,6]. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but is very inefficient at generating mature interleukin-1beta (IL-1beta) from pro-IL-1beta [1,4]. Both this enzyme and caspase-4 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17) [3]. Unlike caspase-4, this enzyme can be induced by lipopolysaccharide [3]. Belongs in peptidase family C14.",384,1.0,-0.045267787,-0.110967375,-0.040792953,-0.030928267,0.04362978,-0.021038124,-0.06454238,0.07146835,0.03603111,0.042211823,-0.014249698,-0.010069809,-0.0019438813,0.06510509,0.059186634,-0.0030648184,-0.009148808,0.0014118857,-0.0059177927,-0.040925387,0.054180793,-0.0738334,0.0456775,0.022025378,-0.030648483,0.014110102,0.05581724,-0.033559132,-0.045290288,-0.03127989,-0.037101682,-0.09654687,0.023209492,-0.055025026,0.039429784,0.0152075,-0.10725896,0.02387499,0.049310826,-0.036988743,0.074051104,-0.018013956,0.026953358,-0.11248941,0.08520736,-0.043998968,0.018255545,0.06964348,0.03708828,0.06494251,0.0044181487,-0.014413117,0.027463162,0.050815713,-0.04402815,0.018112939,-0.039459605,0.011498309,0.058025964,0.026075415,-0.06590448,-0.04035769,0.040239412,0.016214913,-0.027245952,-0.08334866,0.009447305,-0.0062532206,-0.054239295,-0.012329781,-0.014585618,-0.010706436,-0.0650962,0.10769331,0.06182457,0.10156578,0.045504577,-0.029798254,0.01840965,-0.06250333,0.09683914,0.03565095,0.07105408,0.10014751,0.022515561,0.008326806,0.012901747,0.019122612,0.012956726,0.017891383,0.035097234,-0.022711249,0.01065793,0.041073803,-0.020905007,0.055527054,-0.07269485,0.023449307,-0.048262145,-0.012768232,-0.034487702,0.0044769105,-0.014384808,-0.06700216,-0.018061657,0.07947912,-0.028411562,0.046277825,0.025545292,0.033920094,-0.0034464179,-0.056948915,0.013148219,-0.064770676,0.020990552,0.13478923,0.008029672,-0.025049688,0.08009537,-0.023301058,0.00677929,-0.0628999,0.026854876,0.003267552,-0.0515888,0.057873946,-0.013767127,2.0667084e-33,0.0049716095,-0.00072703295,-0.0062140594,0.048843794,0.04820857,-0.03542681,0.02425983,-0.00991109,-0.08470398,-0.012894435,-0.01798314,-0.043144487,0.03749892,-0.021326838,-0.01908085,0.027928373,-0.014707684,-0.01770883,-0.027244287,-0.008447648,-0.018074356,0.012494319,0.003766056,-0.026238909,0.033227935,0.040436585,-0.0136817675,0.05623763,0.0030613777,-0.008923275,-0.08054637,-0.0105392,-0.054480202,-0.015097637,0.01405285,-0.01974655,0.038503062,-0.054732718,-0.046434242,0.06367655,-0.09192607,0.005697348,-0.07523667,-0.07984974,0.081925794,-0.15105739,-0.020452276,0.011173153,-0.06358401,0.0760642,0.08711232,0.015703484,0.05924678,0.054454815,-0.050625812,-0.014083288,-0.008840973,0.018679067,0.073255815,0.0042730914,0.067921795,0.001975594,-0.042791024,0.084640704,0.022159629,0.04674012,-0.04084211,-0.048033718,-0.083766915,0.077702194,0.034710698,-0.03101611,-0.06923148,-0.032476448,0.04804791,-0.048079774,0.05729107,0.093556106,-0.045627784,-0.0050344705,-0.034441542,-0.007148773,-0.013272939,0.10092446,-0.055854823,-0.012210647,-0.014965402,-0.064411245,-0.020444373,-0.069326535,0.0897531,-0.03986492,-0.014445067,0.14769475,-0.04295298,-3.6735558e-33,0.020637972,-0.023314903,0.07077103,-0.15561135,-0.13091181,0.059057113,0.071382724,-0.024492731,0.025581928,-0.049783528,-0.038567454,-0.047076356,0.0056984634,-0.016350925,0.007430539,0.0035358327,-0.052527107,0.050666865,-0.052626833,0.02994599,0.1250744,0.10101685,-0.032600988,0.15566182,0.042647343,-0.030605594,0.0042780316,0.06652649,0.042160034,0.032951724,-0.077633016,0.0026130318,-0.006075111,-0.035594862,-0.03346924,-0.008666886,-0.011882013,-0.019288935,0.026869552,-0.0008248389,-0.075087294,0.03364128,-0.0014478986,0.05196612,0.01465531,0.039464667,0.0058302395,0.04435175,0.041522156,-0.0050923894,-0.06164056,-0.026930263,0.024051879,0.05342489,0.018566247,0.0010194067,0.041264165,0.012880805,-0.0123394495,-0.06363777,-0.058811635,0.0048498213,0.012015503,0.017842792,0.104495846,0.03704331,-0.045787856,-0.04888664,-0.028523004,0.038534597,0.037830457,-0.009019627,-0.070700906,-0.013357026,0.011125772,0.04640407,-0.039255843,-0.043033265,-0.009618266,-0.0012850089,0.0003052962,0.0071287467,0.02097753,-0.09376774,0.007776318,-0.010706976,0.03784056,0.07207863,0.0055306787,0.10102408,-0.015814979,-0.023021948,0.0039410116,0.07147878,-0.05142375,-5.351784e-08,0.088584244,0.02210332,-0.024970619,-0.052273348,-0.10616883,-0.048295606,-0.047264207,-0.012182561,0.023118109,-0.07229784,-0.012296557,0.117665574,0.014014423,0.033989858,0.041038334,0.08177763,-0.009369306,-0.018272294,-0.013236103,-0.007449076,-0.0007072745,-0.06461242,0.0020843346,-0.03442131,0.024633775,-0.11162223,-0.02479248,0.032260474,0.013911078,-0.04011192,-0.08857532,-0.006894973,0.03328345,-0.0818608,0.049379315,0.07184725,-0.040299274,-0.039561242,-0.0451656,0.021309437,0.07300102,-0.06599664,-0.008520685,-0.08015293,0.023388134,0.025424965,-0.034597564,-0.019334115,0.006684909,-0.033251025,-0.12216683,-0.06308567,-0.04226842,-0.04946422,-0.067115374,0.029453345,-0.085911214,-0.017606355,0.08694527,-0.0830203,0.0324172,0.08593283,0.11530815,-0.019138701 +3.4.22.59,"Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-7 (EC 3.4.22.60) [2]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [2]. Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC 3.4.22.61) and leads to the release of cytochrome c from the mitochondria. The release of cytochrome c is an essential component of the intrinsic apoptosis pathway [1]. The enzyme can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragmentation in the final phases of apoptosis [2,4,5,6]. Belongs in peptidase family C14.",384,1.0,-0.042454906,-0.07641998,-0.063313805,-0.030318469,0.03552281,0.03317347,-0.047200847,0.08817357,0.046573184,0.06395381,0.0045752595,0.05009461,-0.0345507,0.022728946,0.0028569074,0.07435576,-0.1198594,0.021072343,-0.010355268,-0.0133453095,-0.0078023155,-0.041185625,-0.004946909,0.024801372,0.011234314,-0.019850858,0.018894209,-0.041603614,-0.054385606,-0.017753644,-0.057224806,-0.06823171,-0.0061062323,0.009698313,0.056469373,0.10819522,0.00030077406,-0.009427463,-0.031489942,-0.08186731,0.062328093,0.0106642665,-0.009334916,-0.03437853,0.064991996,-0.01860428,-0.034860812,0.010742204,0.030764576,0.026409928,0.016111227,-0.060054082,-0.012140678,-0.009707592,-0.060077704,0.02934062,-0.0071235327,-0.055482537,0.07696817,0.025847077,-0.112898566,-0.03423063,0.019092893,0.058210123,0.02652733,-0.04847302,0.044841982,-0.039388463,-0.094513245,0.034428626,-0.061319117,-0.028821416,-0.016401786,0.051681068,-0.02654539,0.057845682,-0.0124052465,-0.088585325,-0.037813142,-0.035102703,0.10663092,0.018115062,0.030827502,0.09835108,0.020903219,0.0055147633,0.050491814,0.014043427,0.020999696,0.056078006,0.023751218,0.022318484,0.015479209,0.026182998,-0.08438226,0.07469245,-0.005025918,-0.012023536,-0.027225105,-0.026397727,0.019352317,0.0026770674,-0.043860156,-0.1236573,0.07086514,0.042291164,-0.06596972,0.11796096,0.062221084,0.03142709,-0.010458076,-0.012366686,-0.03246198,-0.038711384,0.040453304,0.15582019,0.018622667,-0.046435952,0.0769443,0.0056680287,-0.009323483,-0.00086354895,0.0061105066,0.02485771,-0.061658736,-0.0319807,-0.024367986,2.9236644e-33,0.012756815,-0.022460807,0.021743396,0.06390048,-0.008246873,-0.020606106,-0.022769546,-0.10849134,-0.04185207,-0.025568647,-0.031504147,-0.05694605,0.024936045,-0.045515995,0.025466895,0.04687258,-0.01796539,0.04659881,-0.028325066,-0.04589858,0.0014094404,0.01843346,-0.016682362,0.012217657,0.054918207,0.08399085,-0.04296276,0.05797066,-0.039455038,-0.021578437,-0.06827667,-0.016551284,-0.068426244,0.06570061,0.04460889,-0.021263178,-0.088855185,-0.04062893,-0.032031026,0.09741892,-0.039890233,-0.011323971,-0.0732593,-0.019290123,0.106834136,-0.12908372,0.019752808,0.013204272,-0.076448455,0.05009303,0.053405426,-0.042556368,0.07155908,0.06508952,-0.048327617,0.0053911484,-0.027516581,-0.008765736,0.08153905,-0.00040133085,0.1166383,0.012510351,-0.06011731,0.06479511,-0.0230948,0.037750818,-0.045758963,-0.099221416,-0.043011468,0.08077866,0.0028282197,-0.03933455,0.026469288,-0.004988266,0.052046966,-0.0136896,0.0051524024,0.03840923,-0.047831833,0.081211396,0.042706233,-0.0019566044,-0.03839016,0.03165579,0.00066039193,0.041476406,0.0039857947,-0.044133563,-0.02053393,-0.022555647,0.11943628,-0.07856852,-0.06028686,0.07491776,-0.041783325,-4.0045463e-33,0.06177053,-0.046694793,0.06965599,-0.11267922,-0.089499645,0.0034235162,0.027809706,-0.061527207,0.03647633,-0.08548916,-0.030158503,-0.037049904,0.0106089655,-0.0007332004,-0.008056704,-0.0056456504,0.012149947,0.051736165,-0.021181766,0.053673923,0.041626588,0.054740705,-0.007752366,0.13796966,0.047508493,-0.05538943,-0.014123988,-0.03950301,0.10601703,-0.038747635,-0.057253465,0.084152654,0.039659612,0.027349617,-0.003158336,-0.043277375,-0.028649708,-0.019950645,0.07888911,-0.007736769,-0.032486036,0.044015616,-0.012533683,0.018352197,0.04520725,0.035729915,0.007372764,0.052450143,-0.003487532,0.025869465,-0.021272263,-0.054002147,-0.030582432,0.057759527,0.029026372,-0.024493076,0.020081246,-0.016047487,0.01032102,-0.038191725,-0.04278746,0.002282803,0.0040537654,0.083652206,0.07851888,0.11420051,-0.034787063,0.0066216607,-0.082638174,-0.027701404,0.053473946,0.016164701,-0.09273692,-0.038162723,0.0026887716,-0.014283222,-0.0034950525,-0.027819907,0.022385871,-0.01594909,-0.040229432,0.05384732,-0.018960632,0.023783429,-0.014939536,-0.024596026,0.024326777,0.024294,-0.020034762,0.006605759,0.016689466,-0.037675057,0.007985382,0.09208969,-0.04650977,-5.2669165e-08,0.082177706,0.009691116,-0.037714135,-0.110893115,-0.036703892,-0.043768667,0.015963672,0.011380059,0.034222707,-0.051649008,0.015722584,0.11645615,-0.0007707389,-0.016234653,-0.0010748168,0.074359305,-0.03693197,-0.024754444,0.01726167,0.005687908,-0.012060006,-0.08669221,0.0065866024,0.0640051,0.021916632,-0.03602977,0.03729362,0.060818564,0.051978778,-0.075467885,-0.045383025,-0.029328354,0.0006437091,-0.06453313,0.029630946,0.12942192,-0.0051181377,-0.09506647,-0.024308885,0.122034706,0.017021555,-0.06267969,-0.00034826813,-0.063504435,-0.020607453,0.03635765,0.0038167385,-0.0011376909,0.01317083,0.027435534,-0.037929755,-0.075668715,-0.041533012,-0.11560386,-0.06353458,0.025768405,0.0091793435,-0.08841884,0.07616913,-0.06462397,0.09344414,0.013018984,0.13537079,-0.022870043 +3.4.22.60,"Caspase-7 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-6 (EC 3.4.22.59) [1]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [2]. Although a hydrophobic residue at P5 of caspase-2 (EC 3.4.22.55) and caspase-3 leads to more efficient hydrolysis, the amino-acid residue at this location in caspase-7 has no effect [3]. Caspase-7 is activated by the initiator caspases [caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63)]. Removal of the N-terminal prodomain occurs before cleavage in the linker region between the large and small subunits [4]. Belongs in peptidase family C14.",384,1.0,-0.015364637,-0.11277003,0.049446966,-0.029715117,0.065650344,-0.011489238,-0.009300215,0.0889425,0.051471747,0.05936776,0.014935171,0.03690048,-0.08392326,0.07432967,-0.020998232,0.031228986,-0.050566614,0.036345843,0.013548714,-0.058563504,0.07259375,-0.02833759,-0.059520457,0.032236125,0.043352105,0.0013497752,0.04264622,-0.018614829,-0.038294207,-0.06579554,-0.06447783,-0.06878736,-0.009779632,-0.044055667,0.004539007,0.111539364,-0.028356254,-0.027946051,-0.0027268084,-0.053104702,0.11006748,-0.008455728,0.01843643,-0.080502376,0.014379492,-0.021176673,0.006179068,0.029406296,-0.018496715,0.04757565,-0.010973129,-0.03358317,-0.01051205,-0.026214102,-0.12033506,-0.037239894,9.447105e-05,-0.012628496,0.03676038,0.006040983,-0.1202976,-0.017863076,0.031275094,0.014592486,-0.024505995,-0.045321316,0.06786082,-0.05266752,-0.05106658,0.050230134,-0.02067511,-0.018584302,-0.012103567,0.051907662,0.027707525,0.05421657,-0.042131912,-0.03549492,0.004172176,-0.10099673,0.13508303,0.018795164,0.012805318,0.08182235,0.032282237,0.016485743,-0.008708805,0.04051565,0.02271845,0.02800855,0.065872446,-0.009809108,0.020943118,0.062982686,-0.021338582,0.056049004,-0.024829328,0.021448676,-0.062546544,-0.03936954,-0.034377437,0.02254088,-0.006459575,-0.05898708,0.048254568,0.06359792,-0.04953396,0.095985085,0.069099754,-0.03446926,-0.018942952,0.0131209735,0.033640586,-0.031639457,0.008917849,0.08960116,-0.0034777038,-0.05651598,0.059613224,-0.0094291065,-0.008449725,-0.077398956,0.018032424,0.04035379,-0.050145246,-0.017832672,-0.046379298,2.6026207e-33,0.062703505,-0.032208517,0.02176132,0.002252905,0.013641159,-0.033354342,-0.0015200139,-0.06529768,-0.023722524,-0.018998245,-0.045079567,-0.08537995,0.009423308,-0.015421011,0.009384482,0.04192974,0.00770297,0.025264025,-0.05997806,-0.043643244,-0.0044181272,0.010286428,-0.107854195,0.08792608,0.012800997,0.06303252,-0.06579341,0.051194705,0.016283873,-0.020034261,-0.028567202,-0.036082108,-0.059510842,0.110675,0.053966876,-0.021007782,0.004213791,-0.09445864,0.024470799,0.084189765,-0.047438737,0.026916632,0.00957123,-0.03604491,0.094053835,-0.073047586,0.0013198811,0.057383675,-0.07108551,0.07118964,0.11339526,0.01854902,0.09237658,0.058280837,-0.052695274,-0.020761015,-0.059663564,0.01800127,0.060364578,0.0291971,0.07353409,0.0058467225,-0.05135539,0.027616296,-0.049646337,0.07245763,-0.0018827002,-0.07621614,-0.0041301614,0.04226735,-0.0034250852,-0.009163582,0.02691457,0.028016893,0.04953416,-0.05539198,-0.0056140535,0.036219753,-0.04622517,0.05998939,-0.022152197,-0.00086916966,-0.07446812,0.03614701,-0.051604625,0.060448732,0.04791813,-0.0783988,-0.0045462786,-0.028617369,0.1294976,-0.026921907,-0.06757498,0.099078804,-0.0313847,-3.8766573e-33,0.05320813,-0.11031645,0.044891804,-0.0729596,-0.14311448,-0.031888254,0.029353337,-0.034253675,0.056764197,-0.13571401,-0.016697595,-0.020799005,0.043221995,-0.048191566,-0.010107266,0.05175576,-0.013481534,0.06073706,-0.011257683,0.017733952,0.09946613,0.07519118,0.044689063,0.118630484,0.062377848,-0.07371178,-0.023839734,-0.01861818,0.10471283,0.03274647,-0.03898164,0.08693478,-0.003630609,-0.027626133,-0.015278232,-0.054181445,-0.030045727,-0.031667676,0.06544092,-0.05382642,0.001798662,-0.01595248,0.02458816,0.030163873,0.05685391,0.078185774,-0.037360583,0.03289089,0.016972024,0.0028550378,-0.040650364,0.011375855,-0.00888678,0.035160236,0.004438736,0.019178703,0.038664084,-0.0016903416,-0.017902268,-0.007512106,-0.015842268,-0.012351018,-0.0114591,0.03501325,0.05722564,0.11774858,-0.038401935,0.03151445,-0.0021292039,-0.07148501,0.021770619,-0.043683745,-0.05139277,0.01651503,0.016084699,-0.03940899,-0.05536944,-0.029680101,-0.023245094,-0.028105848,-0.051698193,0.058813125,-0.033696562,-0.044505775,-0.008989567,-0.0032191996,0.029800873,0.07302786,-0.03243547,0.039480817,0.016270084,-0.05131572,0.0038592466,0.083117805,-0.032320224,-5.7142998e-08,0.061185364,0.041965403,-0.013520866,-0.09902679,-0.046628915,0.0041306075,-0.041725356,0.032175906,0.0197356,-0.06673756,-0.00597382,0.09118903,-0.05052176,0.027703721,0.030078758,0.06790217,-0.045163725,-0.063841656,-0.01955018,-0.0191319,-0.036082678,-0.07386297,-0.03304655,0.028556557,-0.0035470435,-0.008051023,0.051695097,0.029045735,0.033791516,-0.06550057,-0.066228,-0.0029829282,0.0087513905,-0.077003844,0.058219668,0.14175351,-0.033275615,-0.061337613,0.021449422,0.094620764,0.027103655,-0.10097586,0.026048062,-0.054927483,0.018027589,0.009021186,-0.021468395,0.0075112656,0.009544243,-0.0024064397,0.036157664,-0.065449476,-0.054693785,-0.100570984,-0.04151338,-0.022448685,0.022574024,-0.055670824,0.09646327,-0.067147456,0.067575015,0.0052946988,0.09957681,-0.052770756 +3.4.22.61,"Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) [1]. Caspase-8 is the apical activator of the extrinsic (death receptor) apoptosis pathway, triggered by death receptor ligation [2]. It contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. This enzyme is linked to cell surface death receptors such as Fas [1,5]. When Fas is aggregated by the Fas ligand, procaspase-8 is recruited to the death receptor where it is activated [1]. The enzyme has a preference for Glu at P3 and prefers small residues, such as Gly, Ser and Ala, at the P1' position. It has very broad P4 specificity, tolerating substrates with Asp, Val or Leu in this position [2,3,4]. Endogenous substrates for caspase-8 include procaspase-3, the pro-apoptotic Bcl-2 family member Bid, RIP, PAK2 and the caspase-8 activity modulator FLIPL [4,5]. Belongs in peptidase family C14.",384,1.0,-0.032687772,-0.08994126,-0.06763895,-0.06847154,0.06316647,-0.029259695,-0.027436048,0.16892117,0.089005575,0.048261136,-0.0025963308,-0.00901441,-0.050461996,0.07191459,0.010049654,0.043299433,-0.04460025,0.033665165,-0.052519184,-0.04213124,0.05511937,-0.012389695,-0.0052509727,-0.0114841955,-0.0046741823,-0.001674983,0.024832258,-0.019932806,-0.029368984,-0.05120294,-0.024060082,-0.083844684,-0.004668883,-0.028564105,-0.020971306,0.05780668,0.0014903938,-0.04781718,0.0007944617,-0.048416328,0.04802066,0.006500206,0.018684244,-0.04549148,0.07023737,-0.013411294,-0.021842156,0.045268312,0.028968215,0.035394922,0.0152928615,-0.061036598,-0.014884778,0.03693628,-0.07120774,-0.020351741,-0.025940936,-0.004271343,0.03773706,-0.022327969,-0.07993537,-0.01714508,0.051402517,0.029657211,0.003855151,-0.040953606,0.052146353,-0.04987887,-0.0911223,0.060929168,-0.020537736,-0.05894631,-0.030460782,0.051801007,0.0285877,0.10798237,0.0009261709,-0.029809425,-0.016095381,-0.047388524,0.17131986,0.037985243,0.076490566,0.0841188,0.03384698,0.0018778011,-0.044680823,0.00693657,0.038256936,0.039101414,0.020400923,-0.012263141,-0.055538382,0.047976434,-0.058257233,0.08471651,-0.03122218,0.008345562,-0.07465296,-0.016288577,-0.04478634,-0.027742822,-0.05683446,-0.015096493,0.04067429,-0.0021133672,-0.061049692,0.0912763,0.043073013,-0.018000592,-0.027115135,-0.083987795,0.010659282,-0.04602277,-0.012668268,0.11357337,-0.049880635,-0.030809697,0.07522931,-0.0051889936,0.0017088997,-0.013749858,-0.02853242,0.03000856,-0.02361015,0.04410314,-0.044885922,3.31629e-33,0.040843546,-0.030119093,0.0025075597,-0.004953768,0.030084549,-0.09129915,-0.016769866,-0.012406637,-0.061280686,0.013397941,0.010296903,-0.06987522,0.023018125,-0.020124875,0.011140979,0.0322204,-0.0099014165,-0.0041595576,-0.043462947,-0.10700749,-0.0063627674,0.022311587,-0.019942146,0.032362442,0.033746023,0.07918395,-0.056193978,0.12593329,-0.029547952,-0.019961294,-0.037182696,-0.06540699,-0.053033367,0.0077467305,0.028884223,-0.025098534,-0.0540749,-0.039131165,-0.018547956,0.054590944,-0.0103925895,0.013419461,-0.04303903,-0.011364074,0.08726144,-0.097079076,0.04089018,0.044177,-0.024230272,0.076388165,0.11613996,-0.05275352,0.023573624,0.084214434,-0.047368336,0.050173976,-0.06368078,0.012194309,0.018859202,-0.039689057,0.055418476,0.0011855502,-0.03231969,0.03594452,-0.068300426,0.06089332,-0.044975184,-0.1396523,0.0326742,0.05841569,0.006440908,-0.0028263582,-0.0132627105,0.0073442343,0.027120521,-0.03916782,0.043387122,0.0780466,-0.0049702777,0.05080876,0.016208433,0.005919915,-0.08999292,0.07501949,-0.052647136,0.011614909,0.020866798,-0.08650741,-0.037158675,-0.045006007,0.03926829,-0.046845503,-0.051582783,0.06991427,0.011496518,-4.918594e-33,0.020505797,-0.06126375,0.10726184,-0.050821677,-0.09579855,0.022373248,0.034305643,-0.10495625,0.09411876,-0.02466317,0.019127507,0.0064512044,0.032307815,0.032436043,0.031158779,-0.014877445,-0.058433324,0.036552526,0.016919985,-0.025552377,0.052677386,0.13353182,-0.01245262,0.10826355,0.051289726,-0.09376724,-0.008738534,0.0034982772,0.040747277,0.013007939,0.020791251,0.05883158,0.007892082,0.055538163,-0.03358586,-0.03942748,0.012913332,-0.041065272,0.0022848074,-0.07191163,0.028873146,0.031458955,0.05416661,0.056724783,0.02438517,0.061102275,0.0044179065,0.0910673,-0.013454483,0.029904054,-0.0528433,0.00048788913,-0.042499952,0.039392453,0.01062724,0.016511148,0.02516597,-0.0086797,-0.011706165,-0.07606154,-0.0058562527,-0.026618749,0.03952887,0.059603326,0.091414034,0.080903456,-0.010110132,-0.018721836,-0.02808549,0.023591321,0.11497167,-0.012339324,-0.11491994,0.055217568,-0.010082844,-0.042644504,-0.046387475,-0.016850343,0.0041014515,-0.042812746,-0.07258281,0.010084987,0.030495612,0.02409904,0.0046323417,0.0044957325,0.0028944446,0.118302226,0.03676684,0.050067995,-0.033134263,-0.048354622,0.06290896,0.03172979,-0.08394448,-5.203206e-08,0.05833061,0.015366389,-0.044047672,-0.11106626,-0.09666574,-0.059229385,-0.008831689,0.012025661,0.007752565,0.006850538,0.0019209635,0.126189,-0.0753339,-0.036068555,0.022852233,0.039208062,-0.01148635,-0.00073057576,-0.011239302,-0.029865114,-0.045644566,-0.055908475,0.012963902,-0.036494378,0.06865009,-0.03999038,0.04285099,0.06441586,0.013952216,-0.064234026,-0.031115863,-0.00623253,0.026788538,-0.04218117,-0.008549697,0.058433652,-0.02560012,-0.0257018,-0.06108885,0.09450966,0.026880201,-0.08235837,-0.008627593,-0.0830679,-0.011095013,0.07231242,0.06550257,-0.012486225,0.0061283587,0.0031662025,-0.052144628,-0.08518196,-0.043996777,-0.045124847,-0.0844587,-0.044913236,-0.018789481,-0.009742882,0.101373486,-0.038764227,0.08952262,0.06636179,0.09649183,-0.037486546 +3.4.22.62,"Caspase-9 is an initiator caspase, as are caspase -2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63) [1]. Caspase-9 contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [1]. An alternatively spliced version of caspase-9 also exists, caspase-9S, that inhibits apoptosis, similar to the situation found with caspase-2 [1]. Phosphorylation of caspase-9 from some species by Akt, a serine-threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo [1]. The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage [2,3]. Procaspase-3 is the enzyme's physiological substrate [2]. Belongs in peptidase family C14.",384,1.0,-0.05258337,-0.10385045,-0.031556204,-0.032338988,0.09013654,0.007133149,-0.0264129,0.12496411,0.027027711,0.018825874,-0.016174924,0.0034194607,-0.038588,0.07739588,0.05732182,0.0012939114,-0.03639284,0.05073822,0.009615069,-0.05689556,0.03964972,-0.03655582,0.038256954,0.0122608,0.03693312,-0.012536389,0.0320161,-0.03898803,-0.07553723,-0.031570755,-0.050354633,-0.10052522,-0.038715333,-0.007548677,-0.04872154,0.047712278,-0.053349763,-0.009597578,-0.018217804,-0.060708977,0.073173605,-0.007938209,0.026839914,-0.073375665,0.05988225,0.016260987,-0.019254843,0.013466387,-0.037482277,0.07395426,-0.062796764,-0.03576758,0.014226525,0.0342331,-0.06283567,-0.07746292,0.0046679825,0.012213834,0.05868279,-0.04671378,-0.0349154,-0.003740314,0.047388252,0.016937898,-0.006718225,-0.04132253,0.023126516,-0.028191522,-0.06315033,0.051949497,0.05617606,-0.027187169,-0.02683431,0.049738795,0.031830795,0.12947004,0.022244986,-0.014071794,-0.032278474,-0.02773189,0.17030531,0.038767505,0.064279914,0.09413126,-0.0057268096,-0.008580578,-0.023580799,0.023537261,0.01793986,0.021555593,-0.0031732973,0.0055329506,0.0022014675,0.017847091,-0.05887374,0.055594876,-0.098239265,0.037393764,-0.12863103,-0.0071411203,-0.024248878,0.008074097,-0.063395694,-0.055493675,0.086049944,0.04220312,-0.052070513,0.049449578,0.07080516,-0.029994356,0.021874458,-0.05245629,-0.004262532,-0.05392672,0.013133151,0.12342027,-0.0009880612,-0.04144971,0.05701024,0.031192558,0.014276431,-0.06718722,-0.0031312169,-0.027244888,-0.052030396,0.013881635,-0.034200516,4.128426e-33,0.013604563,-0.024157276,0.038478613,0.030384138,0.07352633,-0.07846861,-0.055229843,-0.004633996,-0.03789639,-0.041340593,-0.014149339,-0.081225164,0.031252712,-0.036568694,-0.0016236324,-0.015612442,-0.031611532,0.008106335,-0.015571765,-0.04592689,-0.02617144,-0.016526146,-0.028482268,0.047871213,0.014883478,0.04661122,-0.06803434,0.101495184,-0.007895979,-0.017495772,-0.024925847,-0.019653201,-0.038682576,0.034777544,0.02894783,-0.030991336,-0.044792008,-0.038470853,-0.018663382,0.08090551,-0.056725133,0.0065867393,-0.047767747,-0.051671337,0.10026992,-0.17491372,0.056894872,0.071520746,-0.05338142,0.050260026,0.07971681,-0.02742783,0.057238594,0.104375534,-0.022834597,0.015087047,-0.017472792,0.040710866,0.015583352,-0.02425769,0.102170095,-0.07046701,-0.028408373,0.06973737,-0.058762938,0.035581663,-0.030041955,-0.10182547,0.006039458,0.04077465,0.04991621,-0.0028242518,-0.02964919,-0.013924342,-0.003611474,-0.01554564,0.074394226,0.09787847,-0.025475428,0.036270805,0.038564052,-0.022885581,-0.08576281,0.09468471,-0.030584447,0.043383338,0.015439177,-0.036482394,-0.060879022,-0.064247765,0.08831781,-0.0028841058,-0.07597347,0.06745209,0.00979778,-5.116273e-33,0.047734972,-0.01845576,0.047783326,-0.08838688,-0.13061504,0.020979457,0.058641396,-0.0517041,0.011903436,-0.074844904,-0.021191426,-0.086216904,0.057123743,-0.040458664,0.011071035,-0.03490732,-0.0086991405,0.062384937,0.011258961,0.032401018,0.07344028,0.118762486,-0.011436756,0.112826824,0.027082596,-0.0808678,-0.02475477,0.046202824,0.053838976,0.031896036,0.010332304,0.026079236,-0.013792388,-0.012941851,-0.039252583,-0.03189568,0.088208295,-0.01564143,0.036126032,-0.061992448,0.035907384,0.021726225,-0.0027278187,0.04215129,0.043458525,0.07924958,0.012611087,0.09361202,-0.040441655,0.0064097,-0.053012803,-0.030618554,-0.02883198,0.026261505,0.0049974676,0.03734063,-0.0049782027,0.022596925,0.012225305,-0.05202409,-0.0672731,0.013261001,0.03030761,0.05377335,0.0900414,0.076404445,-0.039323267,0.050941665,-0.011006443,-0.05109027,0.044034358,0.017902585,-0.10846697,0.014490128,-0.035007212,-0.000980893,0.0074032103,-0.0025903773,0.035660062,-0.05374743,-0.037066333,-0.016006248,0.017644918,-0.04743899,1.7331713e-05,0.028903505,0.013326865,0.07312215,0.0060670804,0.031968094,-0.028515698,-0.045727767,0.018966643,0.06593881,-0.06953919,-5.1513652e-08,0.10365946,0.010459334,-0.03158048,-0.079372056,-0.08412855,-0.09241869,0.005740308,0.040773544,0.013089579,-0.02194119,-0.0007563752,0.09268439,-0.057356566,-0.021547357,0.05395146,0.02802623,0.02271916,0.024154559,-0.026843606,4.2284755e-05,-0.05923711,-0.09002828,0.039546624,-0.0023844847,0.027113372,0.009619419,0.0033262866,-0.009071964,0.069681,-0.063079365,-0.065625146,-0.03256647,0.024416566,-0.099027894,0.04136785,0.060252603,-0.033940505,-0.034003206,-0.01649114,0.07372177,0.0069953483,-0.04709957,-0.026629606,-0.04185775,-0.015045442,0.062015753,0.03449477,-0.0043556443,0.0017966483,-0.04671036,-0.052206054,-0.033833988,-0.03842726,-0.04981401,-0.11485734,-0.045175087,0.017823447,-0.004013659,0.07821427,-0.037338115,0.09631531,0.071862936,0.071937904,-0.048362043 +3.4.22.63,"Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62) [1]. Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-kappaB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation) [2]. Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp! to yield the pro-apoptotic p15 fragment. The p15 fragment is N-myristoylated and enhances the release of cytochrome c from mitochondria (which, in turn, initiatiates the intrinsic apoptosis pathway). Bid can be further cleaved by caspase-10 and granzyme B but not by caspase-3 or caspase-8 at Ile-Glu-Thr-Asp! to yield a p13 fragment that is not N-myristoylated [2]. Belongs in peptidase family C14.",384,1.0,-0.13361232,-0.0823407,-0.029820753,-0.08835658,0.055926695,-0.017095435,-0.042552814,0.14194795,0.069166265,0.020188652,0.00028913323,-0.008712447,-0.04062095,0.080282256,0.049951147,0.032456335,-0.07828787,0.06305811,-0.0846043,-0.04761426,0.042431533,0.011410178,0.022067,0.010878591,0.02086526,-0.0072186603,0.044420313,0.01182205,-0.041867763,-0.04389776,-0.0023177085,-0.08413146,-0.05050325,-0.023450654,0.0052830256,0.04942843,-0.007063519,-0.016124086,-0.02442062,-0.056267638,0.05502491,-0.024650672,0.022653582,-0.041472588,0.06532319,-0.022285981,-0.045671605,0.08543525,0.053350247,0.056819465,-0.023107832,-0.017797,0.018432936,0.08274069,-0.033898212,-0.022649912,-0.051193364,0.014371006,0.045813635,-0.034893185,-0.09573962,-0.005945722,0.046166595,0.023183364,0.016634347,-0.00041901035,0.0147289485,-0.0322262,-0.09835088,0.06180357,-0.0017271454,-0.08876887,-0.063890874,0.075432114,0.00519172,0.14068685,0.023460122,-0.03757808,-0.047006983,-0.04954329,0.1004012,-0.0030398378,0.041779604,0.10706879,-0.0038298173,-0.02799645,-0.003573955,0.024664288,-0.01694412,0.044746824,0.019856373,0.008238441,0.008665324,0.042288065,-0.04011099,0.06917128,-0.033666458,0.0501433,-0.081791185,-0.037764836,-0.09002283,0.0009716619,-0.047510494,-0.07751428,0.07826482,0.0039456934,-0.05141983,0.053437054,0.11245582,-0.013873692,0.02188671,-0.015473365,0.028688835,-0.05270107,0.010860802,0.0666568,-0.09249123,-0.037503764,0.040757775,-0.05758712,-0.03505008,-0.06067847,-0.0676093,-0.0144758485,-0.057365786,0.037662886,0.004097556,2.8459385e-33,0.0551401,-0.044238366,0.014075378,0.055292077,0.0049009384,-0.08311194,-0.008600023,-0.010770557,-0.05755668,-0.04881154,-0.011087855,-0.067886144,0.02437857,-0.030895384,-0.048954256,-0.008885865,0.0076685753,0.011354828,-0.08537387,-0.027702602,0.008028,0.05818808,-0.029106898,0.005388995,0.0117950365,0.06670513,0.0067917453,0.09835107,-0.015308833,-0.0013341617,-0.05241094,-0.04214622,-0.05585548,0.02581345,0.010680651,-0.023499366,-0.013379562,-0.035806768,-0.015895475,0.0637937,-0.040961623,-0.0009783232,-0.07459397,-0.005445331,0.059069037,-0.13814141,0.03618107,0.023815388,-0.030425083,0.050651524,0.08684041,-0.0033139915,0.039930463,0.10425091,-0.028493451,-0.023509659,-0.0654543,-0.00083725835,0.027434645,-0.016175741,0.075108565,-0.0016316655,-0.06361598,0.061210316,-0.027357599,0.069077246,-0.026643815,-0.10619768,0.02244031,0.035384152,0.026513556,0.0012134055,-0.003848954,0.00097375485,0.040086105,-0.009205726,0.08398169,0.07214663,0.029409865,0.08718257,-0.023138454,-0.0151738,-0.07235734,0.08128158,-0.048657507,0.0032983853,0.0062300954,-0.085424446,-0.05817347,-0.06699329,0.039553866,-0.047315314,-0.03829618,0.07953355,-0.0033707896,-3.993272e-33,0.041861013,-0.089568794,0.069116585,-0.05558329,-0.11675427,0.027269756,0.039622694,-0.057041306,0.05786383,-0.047958508,0.033303108,0.0007914944,0.03501632,-0.012208192,0.010226667,-0.019060366,0.0020284697,0.06985022,-0.04565245,0.0127096,0.06646949,0.15139453,-0.01705343,0.10777851,0.033228576,-0.03008585,-0.012868696,0.019812388,0.048056353,0.019810256,0.055408947,0.09328631,-0.0034982315,0.0048162057,-0.053980034,-0.022956373,0.04982256,-0.06626431,0.0017810436,-0.073077105,-0.0027898184,-0.0012974007,-0.024641821,0.062631495,0.05146836,0.06748147,-0.0063767117,0.06469916,-0.0010242815,0.05429644,-0.0037933835,0.02927506,-0.012718796,0.057548925,0.0067798374,0.0138580585,0.00016992657,0.017205715,0.010658222,-0.049725246,-0.03134635,0.031893793,0.08482608,0.03141078,0.077034496,0.10910582,-0.0122559965,-0.00912277,-0.022052651,-0.035195768,0.065762565,0.03256226,-0.06736548,0.0029413176,0.013660422,0.013765144,-0.040825658,0.008811046,0.02874429,-0.014764325,-0.078485996,0.0025356212,-0.0063841115,0.00010213303,-0.007611413,0.011986389,-0.036893226,0.07945724,-0.007906909,0.04232831,-0.07817695,-0.060595274,-0.0071803504,0.11385675,-0.03255998,-4.9426607e-08,0.070335835,0.025583794,-0.028722826,-0.072076224,-0.073470905,-0.026687242,-0.016166916,0.029648196,0.03965396,0.014554186,0.006778276,0.09294939,-0.09264778,-0.03131163,-0.016072903,0.024223285,0.01699047,-0.0220729,-0.009198272,-0.004310469,-0.020056656,-0.06690559,0.061825894,-0.027527085,0.027262218,-0.038185276,0.06283025,0.03887118,0.04342135,-0.08326706,-0.043193385,-0.026730038,-0.015330008,-0.049398273,0.02774717,0.08494846,-0.029071825,-0.024385443,0.008100139,0.14042161,0.0149968285,-0.09768827,-0.002115675,-0.029813513,0.02353196,0.035587873,0.0016682175,0.0350363,-0.049292076,-0.0720815,-0.0572526,-0.06877355,-0.041399017,-0.06749423,-0.11108898,0.041222576,-0.013955904,-0.018693155,0.09819671,-0.006832232,0.092077605,0.015040446,0.06789227,-0.023034923 +3.4.22.64,"This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide [1]. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions [1,2]. Belongs in peptidase family C14.",384,0.99999994,-0.02973559,-0.09290744,-0.03689924,-0.04852364,0.046272524,-0.0080185905,-0.046951424,0.10460726,0.061827224,0.02524926,-0.03414423,-0.03885383,0.03646494,0.045795698,0.024162626,0.01838089,-0.04487692,-0.0036389611,-0.020630356,-0.06955951,0.06165935,-0.062266923,0.032096725,0.028550418,-0.07911384,-0.00015979956,0.047536314,-0.01207644,-0.053332582,-0.017367832,-0.013546463,-0.088538006,0.026138518,-0.019346695,0.006918611,-0.0043901973,-0.060049962,-0.0047486075,0.029121453,-0.017748065,0.04444182,-0.009039018,0.02442309,-0.06413697,0.10245212,-0.039237697,-0.0004681585,0.06388171,0.044166397,0.06274276,0.0071821073,-0.035391204,0.047297694,0.042659134,-0.045649886,-0.001587387,-0.06668609,-0.0051383907,0.06475115,-0.0032180662,-0.09190343,-0.024893383,0.052024316,0.021795293,-0.049124923,-0.051612157,0.009027815,-0.031921923,-0.086081654,-0.004432829,-0.0322345,-0.048332553,-0.019159032,0.09490239,0.043492474,0.099583164,0.045197893,-0.053477496,0.013075984,-0.06548168,0.12142479,0.030000873,0.06956691,0.07851442,0.028780274,0.014654497,0.0087871095,-0.0058114314,0.016776107,0.0060658343,0.043094464,-0.059439294,0.0027455986,0.032203197,-0.03139988,0.09124391,-0.07939102,0.029056385,-0.05809714,-0.0053505534,-0.034057062,-0.013277951,-0.064187154,-0.077053085,-0.0030623612,0.085668825,0.0064724414,0.035434607,0.045098975,-0.0018963573,-0.01022968,-0.06540986,-0.0052785976,-0.04369885,0.024861088,0.11119754,0.036474578,-0.017091729,0.054487936,-0.029704865,0.030532481,-0.05115594,0.013133447,-0.0012170525,-0.06731602,0.03767442,0.0030409705,2.612171e-33,0.015760165,-0.022565361,0.00080981205,0.052558117,0.06867441,-0.028973764,0.008967706,-0.013821213,-0.0897485,-0.013994999,-0.013213459,-0.053033177,0.0013070239,-0.013729101,-0.03469849,0.043571997,-0.023810416,-0.048369296,-0.010008364,-0.022631451,-0.024852037,0.025011383,-0.0069981287,-0.004276278,0.042337738,0.06367956,-0.040343598,0.03953723,0.007899241,0.0011071172,-0.089722306,-0.006274285,-0.06510626,0.0047894316,-0.005873171,-0.0048201224,-0.002982898,-0.017238522,-0.03180587,0.07577452,-0.06312402,-0.007761165,-0.07770013,-0.067532286,0.08575878,-0.13672635,4.4867946e-05,0.0020480417,-0.027818294,0.08919322,0.07638783,-0.025954913,0.08418067,0.053480256,-0.031655304,0.005405019,-0.029485928,0.009483262,0.064878546,0.010833542,0.041898828,-0.021175928,-0.05546824,0.081392564,-0.0078835115,0.048143134,-0.05295956,-0.08404775,-0.039744392,0.093209274,0.044946663,-0.008454055,-0.060811017,0.0071531725,0.045668263,-0.04151813,0.059895292,0.090733,-0.0758923,0.011879963,-0.03094347,-0.020303173,-0.031452797,0.09918979,-0.022774113,0.016380463,0.003069631,-0.042252176,-0.03167902,-0.073825985,0.10863994,-0.038433872,-0.046105858,0.12920238,-0.009526045,-4.5032976e-33,0.02112785,-0.053054232,0.07671564,-0.124104366,-0.12058203,0.061387803,0.06659563,-0.041118994,0.069656685,-0.03504046,-0.012867394,-0.038855236,-0.014097901,-0.019182263,0.0121773,0.02079089,-0.018182881,0.031055715,-0.07551935,0.0071230005,0.07601069,0.091091305,-0.025503196,0.15679744,0.070220806,-0.030525383,-0.018808547,0.027171042,0.076911956,0.017658843,-0.08796386,0.014607953,0.02738386,-0.031666048,-0.010015891,-0.020871436,-0.0018501006,0.01643745,-0.023303237,-0.019195437,-0.057408802,0.052644722,0.0059075104,0.08071159,0.022769637,0.08583319,-0.024630688,0.06532831,0.052380055,0.0009747456,-0.06823162,-0.0469795,0.053630453,0.042706735,0.035577506,-0.019825557,0.034581445,0.015808308,-0.016458813,-0.04614105,-0.05800133,0.011828119,-0.0085001215,0.03155211,0.117724285,0.051381342,-0.05706761,-0.039915025,-0.00473114,0.014190611,0.066670924,-0.0022135612,-0.081967734,-0.008314824,-0.018880932,0.042910054,-0.030172056,-0.05319269,-0.0035801914,0.009221928,0.0073596034,0.0034064024,0.017086606,-0.065880574,-0.029733006,-0.001183347,0.039930277,0.058978636,0.019286226,0.071443655,-0.008957675,0.0036036514,-0.013046212,0.018914033,-0.06746392,-5.906429e-08,0.063329645,0.016578503,-0.044127975,-0.0983087,-0.119089164,-0.038556013,-0.010893089,0.008092008,0.048614558,-0.053380255,-0.0058839265,0.12212213,0.029495995,0.026196623,0.028756557,0.08689504,-0.011979253,-0.025089147,0.0074801333,0.021144405,-0.02753231,-0.059327636,-0.01763644,-0.008653328,0.017424181,-0.106894374,0.014251445,0.035959225,0.019662645,-0.046366494,-0.06971326,-0.02402783,0.035807475,-0.046210457,-0.00046085464,0.058270887,-0.06069911,-0.0612219,-0.05212046,0.051487204,0.060192145,-0.05429377,0.024407178,-0.11444488,0.010591887,0.010121795,0.001450866,-0.010804392,0.026425682,-0.03478385,-0.11301154,-0.058636993,-0.047717065,-0.030866861,-0.087880135,-0.0053931195,-0.066562116,-0.027831482,0.13177842,-0.11957593,0.057002697,0.0827598,0.1127857,0.017453013 +1.1.1.292,"This enzyme is present in some but not all Rhizobium species and belongs in the GFO/IDH/MocA protein family [2]. This enzyme differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro-D-mannitol, can be further metabolized to D-mannose [1]. The enzyme also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. It does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones [1].",384,1.0,-0.023655476,-0.07541049,-0.06518769,-0.03285841,0.01999741,-0.013153904,-0.07202628,0.06778742,0.029522734,0.029402887,0.0045937975,-0.028608553,-0.056749802,0.008938188,-0.016448589,0.020940442,0.008595874,0.021659607,-0.09289328,-0.06771605,0.09701771,-0.063696496,0.019704605,-0.0077941264,0.0024774722,0.023167321,0.027793854,-0.028209731,-0.08958664,-0.15148371,0.01605609,-0.09294006,0.04097874,-0.074067764,0.06290112,0.07314193,-0.01951314,0.036481664,-0.00088297424,-0.036311526,-0.0047176545,0.009540085,0.044186972,0.034069743,-0.057842974,-0.032373074,-0.08368805,0.052619107,0.031642035,0.038801476,-0.07169322,-0.056312434,0.00030979404,0.04371299,0.0036291592,0.0107466765,-0.026407119,-0.011955536,-0.02138912,0.01640854,-0.02438047,-0.015328036,0.039159484,0.008531712,-0.053456478,-0.04595103,-0.042122204,-0.13664448,-0.04078717,-0.017371608,0.004728413,-0.07973297,0.05935611,0.02847258,-0.00674671,0.013405492,-0.04217595,0.016491914,0.075979285,-0.012762602,0.040540066,0.031886373,0.06984635,0.04613688,0.04044644,-0.038499657,-0.0678225,-0.011416312,0.06725833,-0.0057332353,0.07390533,0.029689142,-0.03549266,0.010819124,-0.04141346,0.0074271066,-0.0014988384,0.058609203,-0.04585441,-0.03228225,0.08382565,0.0069636004,0.003570479,-0.108058274,-0.086243816,0.067343146,-0.023990812,0.021062683,0.044990823,-0.038564865,-0.024151985,0.07098713,-0.013812584,-0.009775876,-0.041714594,0.05952012,0.09076684,-0.023127802,-0.032294456,-0.008310149,0.015744664,-0.03262795,0.058440816,0.017831255,0.035091847,0.021128468,-0.084794216,1.3157783e-33,0.053793795,0.025657525,-0.048840858,-0.034913875,0.049517546,0.03365007,-0.051236566,0.06691686,-0.099614315,-0.040273886,-0.15163486,0.0039192443,-0.0037590384,-0.005200398,-0.018292645,0.05528663,-0.061466165,-0.019883152,0.058890067,-0.004817387,0.032799628,0.02366999,-0.10623638,0.04237844,0.03440177,0.117903925,0.0063398653,-0.005672084,-0.020862805,-0.004875834,-0.010563702,-0.040240224,-0.056398176,0.04907744,-0.039758317,0.04917744,-0.06560138,0.031990636,-0.05410847,0.04843821,-0.009228235,-0.009327315,-0.065671034,-0.037759632,0.051392607,-0.06545195,0.00012968341,0.06896019,0.039862048,0.08006247,0.104944296,-0.068220854,0.061296765,0.09002558,-0.05271844,0.02942016,-0.07928275,0.029234882,0.11956498,0.10088727,0.008928028,0.067795984,0.008261029,0.042445317,-0.034343127,-0.017106755,-0.016738854,-0.026119623,-0.0046141148,0.06754528,-0.0026501738,-0.014195118,0.052484583,0.039212182,0.03356377,-0.0964477,0.006099842,0.059117164,0.031770725,0.00063115696,0.055396643,-0.023147946,0.055511184,0.03693143,-0.078054175,0.041248348,-0.038510397,-0.042364813,-0.057860833,0.031347465,0.020182962,-0.073112555,-0.09659653,0.024647754,0.0070176315,-1.5275607e-33,0.09548645,-0.07579877,0.0960626,-0.032285098,-0.023313267,0.032191597,0.119108595,-0.044441484,0.07675918,-0.10454505,0.08293354,-0.021991387,0.04441324,-0.023478681,-0.020815544,0.02494888,-0.024253549,0.078676306,0.0059735477,-0.044165965,0.001770245,0.13595286,-0.024467094,0.011554524,0.045571104,-0.021666696,0.020088285,0.034198012,0.046982322,0.023005204,0.061453458,0.034628276,-0.052744884,-0.04941101,0.034612373,0.07313562,-0.10203003,0.025224265,-0.011534382,0.07374626,-0.056129307,0.0008967286,0.060229845,0.001722092,0.06282443,0.061771337,-0.124461845,-0.025501946,-0.013377732,-0.0021493598,0.041618682,-0.07601824,-0.015811041,0.08287946,0.046770044,0.031138772,-0.0129044335,-0.010930439,-0.07674822,0.008234358,-0.07867578,-0.013428642,0.04535864,-0.017785862,0.072529934,0.08487526,0.007200972,0.038419295,0.023138678,0.057535995,0.027390355,-0.045117363,-0.023091225,0.09650237,0.008221382,-0.010219552,-0.060519673,0.002741975,-0.016918458,-0.0051056263,0.0033163184,0.016183479,0.039371595,-0.062761545,-0.033984423,-0.03932697,-0.0063137067,0.0782067,0.047406852,0.08592678,-0.02356364,0.021335337,-0.07045595,0.007379114,0.103018366,-4.5749818e-08,0.03904209,-0.06752607,-0.01087792,-0.07082107,0.072097585,0.036288798,0.020115044,0.013296712,0.039017685,-0.02478074,0.051615432,0.08917034,0.017433047,0.012522405,-0.030202435,0.02761603,0.02148021,-0.025942313,0.054623798,0.03287513,-0.06980391,0.017584173,-0.05053113,-0.05022412,0.029723411,-0.041191176,0.0334569,-0.013623895,0.004553821,0.0008250151,0.003347284,0.034231223,0.045953065,-0.050351758,-0.031054627,0.03347207,-0.04703013,-3.2296157e-05,-0.011364613,0.00410557,-0.025481675,-0.04093239,0.02976371,0.010727419,-0.02125501,-0.060597856,-0.09416314,-0.026007298,0.023789829,0.05291722,-0.012515482,0.0030641204,-0.01509353,-0.09782258,-0.10835815,-0.039776597,-0.011181339,-0.03906678,-0.02662061,-0.102746435,0.02065587,-0.033506706,0.13410798,-0.008420286 +3.2.1.162,"The enzyme from Pseudoalteromonas sp. is specific for lambda-carrageenan. iota-Carrageenan (see EC 3.2.1.157, iota-carrageenase), kappa-carrageenan (see EC 3.2.1.83, kappa-carrageenase), agarose and porphyran are not substrates.",384,0.99999994,-0.04705474,-0.09090546,-0.0967907,-0.07189719,0.05606941,0.04020862,-0.04140051,0.01203738,0.02991267,-0.018708829,0.07955432,-0.08916804,-0.10707087,0.13007927,-0.060841683,0.035904206,-0.040353235,-0.0022012806,0.048197445,0.085072234,0.1289664,0.06791044,-0.008788254,0.018567102,-0.017481636,-0.048171934,0.011789308,-0.08464426,-0.012380339,-0.06440685,-0.052713007,0.012586982,0.0730907,-0.0008467884,0.10092106,0.0055380287,-0.039473224,-0.028860373,0.08411882,0.049302265,0.08380689,-0.013810681,0.03898379,-0.059789754,0.026823845,-0.039144307,-0.0085126255,0.012984517,0.01893509,0.024861308,-0.0722508,-0.08259935,-0.063840546,-0.01956635,0.03148036,0.024321847,-0.018982079,-0.07871959,-0.020291096,0.017298743,0.08854577,0.009072994,-0.011588,0.0031321538,-0.027391175,-0.0133386785,0.03534863,-0.023860497,-0.009415994,-0.036598586,-0.03216093,-0.084951565,0.0008553457,0.07663914,0.03711948,0.052207347,0.021549564,-0.048101958,-0.023273664,-0.05096854,-0.04194967,0.0017097035,-0.015252004,0.050189406,0.00071409123,0.0067075435,0.0056408774,0.05173268,0.054488856,0.011562563,0.051292103,0.007873604,-0.021504251,-0.042159203,-0.04886542,0.03275652,0.0046841693,0.03579443,0.014823754,-0.027961813,-0.004675866,-0.03257845,-0.05753331,-0.043464016,-0.06932417,0.043839328,0.010831886,0.010695553,0.053384848,-0.00031135388,0.016379569,0.07279201,0.025237534,-0.03887528,-0.044819962,0.0778992,0.025103759,-0.08940898,0.027287949,-0.0048501347,-0.03901109,-0.070625,0.083891384,0.08308962,0.0033565706,0.038987428,-0.08383706,1.7122276e-33,0.03864483,-0.010395843,0.07390415,-0.05279746,0.056835383,-0.0541008,-0.017509624,-0.048866328,-0.012188024,-0.069362976,-0.10327929,0.015988432,-0.033849593,-0.005699745,-0.002386334,0.022748422,0.0018628116,-0.037686743,0.011926808,-0.00026261015,0.063486114,0.055566516,-0.061092895,0.009420858,0.07267586,0.038414713,0.039676525,-0.052959453,0.024601163,-0.0034892717,0.055552013,-0.093069404,-0.040793363,0.03661997,0.07220184,-0.025591526,-0.00392038,-0.05375475,-0.030428713,0.067576386,-0.009144761,0.007559737,0.04759224,0.04991879,0.03841296,-0.057184067,-0.021293027,0.13165095,0.03176801,0.04138453,0.028647963,-0.037750855,0.01467997,0.0018747168,-0.05741436,0.04413452,-0.06711962,0.0043437467,0.045876686,0.010069873,0.014840497,-0.027459783,-0.018137636,-0.025595885,-0.0106811905,0.04980527,-0.03961872,-0.029714622,0.059797462,0.020170594,-0.026005505,0.00661331,0.025569428,0.028479055,0.10244977,-0.05011047,-0.06402213,0.06569286,-0.036672417,-0.0033008808,-0.0127872005,0.028216714,0.022401748,-0.023897573,-0.11910027,0.013922636,0.036444385,0.006277111,0.04407171,0.050119307,0.082271315,-0.016862987,-0.064708374,0.033270255,-0.028555648,-1.278577e-33,0.04919444,-0.16079439,0.029333813,-0.055758122,-0.069595546,0.049661964,0.0032517426,0.035967406,0.034863457,-0.061427087,0.04032696,0.07066746,0.012200904,-0.09570319,-0.029607225,0.004696194,0.019444404,0.020344337,0.0006992945,-0.048201017,-0.071017556,0.051908687,0.0030900626,0.006701374,0.08326611,0.0020391373,-0.023950914,0.15637226,0.008792311,0.014441473,0.016798072,0.06080997,0.0075367917,-0.020023324,-0.09516932,0.0148942815,-0.04574336,0.02786917,-0.035025887,0.030711144,-0.0026316657,-0.0015043154,-0.07856091,0.059747387,-0.05101715,0.06209406,-0.033335373,-0.038301013,0.024738098,-0.048387095,0.026878286,-0.007969488,0.079007186,-0.02245599,0.032872554,0.090552434,0.013593909,0.013844978,0.02895763,-0.011920943,0.064998135,-0.055301815,0.04306564,-0.03335996,0.09907365,0.12431986,-0.028290614,0.08229333,0.004777735,0.017087987,0.038019672,0.030291788,-0.021880837,0.047501404,-0.04014008,-0.009470562,-0.06859472,-0.05826273,0.021393754,-0.044750612,-0.014831486,-0.02187738,-0.015989913,-0.058746926,-0.0083122235,0.014681124,0.12926897,0.09240175,-0.04548558,0.05113713,-0.02381611,-0.022490382,-0.034553777,0.027939217,0.0070284847,-4.365831e-08,0.03816174,-0.021867042,0.027338834,-0.038987253,-0.040702023,0.0008368898,0.037328225,0.026255986,0.04273184,-0.02969523,-0.078435786,0.03155396,0.026008349,-0.0040079383,0.09649114,-0.039386284,0.0052467007,0.0030384897,-0.04053828,-0.015621211,-0.06556501,0.04570209,-0.15374543,-0.019903986,-0.0684389,0.010340902,0.08744657,0.08510299,0.030938292,-0.032896414,-0.067169055,0.006165556,-0.019175049,-0.02984771,-0.06620231,0.06270392,-0.039516393,-0.092348814,0.0034881318,0.029033344,0.01048637,-0.092251346,-0.023822047,-0.016707165,0.0031570762,0.002085235,0.0055433833,0.014306158,0.051869627,0.006345189,0.095640875,-0.014017551,-0.04888725,-0.06691199,-0.13336709,-0.033357132,0.030260844,-0.048716202,-0.078009754,0.0035483546,0.012362779,-0.03843591,0.19313112,0.016141921 +3.4.21.120,"The egg envelope of the South African clawed frog (Xenopus laevis) is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form. This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin. It is thought that the enzymically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions [2]. The enzyme is also found in the Japanese toad (Bufo japonicus) [3]. Belongs in peptidase family S1.",384,0.99999994,-0.075035185,-0.07444834,-0.06844273,-0.07441746,0.027061176,0.007917299,0.018912263,0.02003893,-0.012956276,0.065237544,-0.012827272,0.023839649,-0.027155627,0.035204217,-0.02667661,-0.034863997,-0.019302335,-0.072277874,-0.0006080013,-0.0476163,0.041289322,-0.023253383,0.04675761,0.001106891,0.008953155,-0.057380382,-0.047234923,-0.017809259,-0.029707536,-0.07101714,-0.04012269,-0.070661165,0.029582737,-0.068995886,-0.0035392717,0.022698864,-0.015093235,-0.033178594,0.025118005,-0.030547133,0.13045453,-0.035123307,-0.059236974,0.015962442,0.011439871,-0.008200439,0.04692197,0.028569264,0.06142561,0.09695128,-0.037309222,-0.11257786,-0.03845989,0.04415601,0.011867634,0.044159822,-0.032614905,-0.00909475,0.043121364,-0.005987234,-0.023561517,0.012993384,-0.01654092,-0.018493028,-0.005782337,-0.063292794,0.02102677,0.0167603,-0.05993525,0.00070875126,0.05184609,0.0568565,-0.013041005,0.00020775339,0.020748949,0.090253875,-0.010427391,0.0028905992,-0.052239936,-0.03660725,0.03101522,-0.019467546,0.09930337,0.0826377,-0.016904991,0.014713462,0.074933216,-0.059005987,-0.006040818,-0.033826422,0.02220438,-0.046736572,0.059916094,-0.017412964,-0.031093465,-0.02779611,0.042822268,-0.0997623,-0.01620142,0.023026356,-0.08280011,0.002505126,0.0806456,-0.13578607,-0.054446094,0.054274935,-0.1361261,0.067411736,0.038770784,-0.018853674,0.010803915,-0.032876413,0.097886115,0.058050998,-0.0049617016,-0.038299054,-0.09801697,-0.023051158,0.019438876,-0.006916416,-0.010952616,0.013711495,-0.016116252,-0.002592727,-0.056529555,-0.01936195,-0.099521175,4.825889e-33,0.09843643,-0.026699817,0.020090386,0.026704106,0.033219557,0.09659121,-0.013456321,0.032102864,0.017307352,-0.029674044,-0.039450455,-0.041095365,0.0322492,-0.014669862,-0.038096067,0.029504657,-0.04407089,0.005042847,0.025508102,0.089393616,0.005515874,0.06114989,-0.021120757,-0.06619709,0.06917578,0.05250225,-0.11422184,-0.05516495,0.01753697,0.02374361,0.054297566,-0.06335574,-0.08378493,0.04565907,0.06977449,-0.029128985,0.049467638,-0.10739593,0.0140602095,0.024509333,0.01901012,-0.087065265,-0.07676799,-0.029198153,0.018381434,-0.053187862,0.01231827,0.008490016,0.036269512,0.041501053,0.023920674,-0.018212246,0.11519148,-0.03280235,-0.12243209,0.045983337,-0.056464057,-0.028403038,-0.024651464,0.029837,0.014327068,-0.0014312696,0.010002618,-0.022253085,0.026702339,-0.015616402,-0.08158094,-0.019876182,-0.001442512,0.037698567,-0.008596941,0.02147493,0.06950284,-0.1049276,0.020777928,-0.048050154,-0.03414954,0.07416445,0.07817408,-0.04210885,0.0029433535,0.09506404,-0.112952985,-0.018162103,-0.05982556,0.036395878,0.11529208,0.00197503,-0.016880704,0.058280393,-0.0016314985,-0.050229404,-0.0004352666,-0.029386172,0.013766117,-4.8002366e-33,0.049351744,-0.08798691,0.023483412,0.03355477,-0.011176036,0.047183745,0.10685715,-0.0072680935,-0.011442464,-0.034138188,0.008085848,0.02500959,0.041904557,-0.009740604,0.03841311,-0.02680185,-0.023277724,-0.013299632,-0.03812351,-0.103973985,-0.028804699,0.019842518,0.09234454,0.045159806,0.07672304,0.0045496924,-0.0008039272,0.06401729,0.10968724,0.051977836,-0.056812953,0.08485824,-0.0033287052,0.027973913,-0.05334479,0.014743619,-0.019385215,0.04106924,0.08562534,-0.073237546,0.007997348,0.016869837,-0.016900722,0.022182636,0.06225083,0.111755334,-0.014308545,0.10855385,0.008674139,0.021903096,0.03609308,-0.04805252,-0.051414907,-0.06207194,0.037028473,0.0097759785,0.002658189,-0.024663828,0.042407144,-0.0012198404,-0.020590948,-0.050642014,0.04291767,0.14237867,0.029583743,0.061659325,0.045366004,-0.017961534,0.078621425,-0.023163546,0.058265615,-0.019089969,0.093832314,-0.020498447,0.03680826,0.023243152,-0.03410383,-0.053993132,-0.010609404,-0.076009676,-0.059678454,0.0071629854,0.011509615,-0.046087153,0.013807885,-0.015109088,0.008998164,0.1252494,0.030381473,0.05043271,-0.051793657,0.008722438,0.033673566,0.06429438,0.10857952,-4.5327123e-08,0.09727875,-0.014592417,0.041576657,-0.0023311803,0.023305753,-0.021166885,-0.004552073,-0.088477336,0.007041982,-0.0727925,0.0014584985,-0.018582743,0.040960796,0.009632237,0.018931776,0.050935183,0.074365556,0.015606635,-0.06264997,0.015060194,-0.11794139,0.027817843,-0.12187428,0.055744763,-0.038710844,-0.0145366285,-0.004613375,-0.016165271,-0.05405058,-0.0384476,0.004426712,0.043802246,-0.029652556,-0.07047531,-0.03192762,-0.009587281,0.019311462,0.017914185,0.016665515,-0.050554097,0.00028707014,-0.043457698,0.02494621,-0.0471668,-0.035457104,-0.010264675,0.060953107,-0.0057883835,-0.028054468,0.01359687,-0.067237504,0.043789063,-0.014909326,-0.07627736,-0.09735636,0.005396802,-0.040179726,-0.054951515,0.016606953,0.039826274,-0.026049705,0.009772246,0.15946345,-0.05654284 +3.4.22.54,"This Ca2+-dependent enzyme is found in skeletal muscle and is genetically linked to limb girdle muscular dystrophy type 2A [1,4]. The enzyme is activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site [4]. Substrates include the protein itself [3,4] and connectin/titin [2,5]. Belongs in peptidase family C2.",384,1.0,-0.06796693,-0.06780148,-0.0030212007,-0.0023738355,-0.03714018,0.009091343,-0.007037825,0.059079304,0.06021416,0.05115566,0.066438496,-0.0060827136,0.0005717015,0.11277646,-0.066322155,-0.012687366,-0.09481956,-0.03804929,0.048732057,-0.09164681,0.039114565,0.02299469,-0.03451532,0.021809205,-0.0072329533,-0.08479555,0.011162141,0.010629562,0.0067431564,-0.015284093,-0.057710037,-0.047700126,-0.011112911,0.022697413,0.033953257,0.055240847,-0.0479588,-0.056511775,-0.054569293,-0.00016584381,0.10328077,-0.028775968,0.011767971,-0.003803836,0.06384591,0.04143753,0.008421502,0.027760867,0.0107186055,0.052385412,-0.06392045,-0.03660564,0.048144262,0.014345711,0.04190235,0.027949642,-0.033025373,0.06261498,0.003849336,0.03232575,0.1287312,0.02308959,-0.0046431078,-0.096882954,0.06016501,-0.032193407,-0.012947712,-0.026137011,0.029072413,-0.04211672,-0.009175966,-0.06834834,0.0024446726,0.058263384,0.043520257,-0.012801718,-0.041279074,-0.0049807196,0.036559362,-0.110480666,0.013720803,0.005106898,0.06729745,0.05803077,-0.0025780364,0.12284492,0.08703713,0.008757736,0.019106308,-0.025307141,0.01788415,-0.014731648,-0.03219994,-0.027784819,-0.011587477,-0.00842101,-0.005642721,0.001091004,-0.0063096993,-0.019697128,0.13655332,0.029101174,0.02797193,-0.01656729,-0.050744772,-0.002076425,-0.0075936937,0.07482138,-0.0077361697,-0.022448795,0.05165984,0.042028014,0.024172906,0.034912962,-0.023785517,0.14520489,-0.016122034,-0.017453132,-0.010666214,-0.030607535,0.010823929,-0.038350448,-0.01836723,0.025274388,-0.0953582,-0.025672264,-0.16276297,2.413951e-33,0.012404206,-0.012659184,0.0075059184,0.0046180706,-0.011663521,-0.031374104,-0.08591484,-0.026165802,-0.026024379,-0.07037205,-0.080566026,-0.034447912,0.028821182,0.10108343,-0.024895737,-0.025782315,-0.03690289,-0.008190033,0.067501225,0.004724891,0.07829571,0.10278722,-0.028986415,-0.032656778,0.07723468,0.04129145,-0.015686013,0.006873523,0.054481756,-0.021572782,-0.0402557,-0.09869326,-0.05146043,0.033286195,0.029124048,-0.072312124,0.09320722,-0.022737073,0.007456498,0.107425705,0.09976932,-0.02570286,0.054404043,-0.028286537,0.037952695,-0.07812794,0.0034370113,-0.0044486634,-0.016901217,0.0065268166,0.078221135,-0.021426318,0.06893783,-0.053677417,-0.09418425,0.011150008,-0.099631235,-0.055832464,0.0054245573,0.030270742,0.068494186,-0.03883178,-0.021841517,0.053991128,-0.054654673,-0.042886067,-0.018995702,-0.056261178,-0.0069884025,0.099042326,-0.071308725,-0.031871825,0.06919626,-0.0033359062,0.0058273785,-0.061500933,-0.06806239,0.112540446,-0.025058689,0.019842114,-0.040089108,-0.009282818,0.0032826378,0.07318945,-0.0008798176,-0.015808022,0.05691694,-0.1128017,-0.04110364,0.08688948,-0.01774338,-0.020609496,-0.039695807,0.1033491,-0.0037069991,-3.8228806e-33,0.047412507,-0.013831501,0.1209183,-0.07834708,-0.055781778,0.061600707,0.0063402033,-0.074613616,0.0700692,-0.065504745,0.06112907,0.0074334354,0.039927494,-0.0036670873,0.03033658,0.047030132,-0.102601565,0.03801708,-0.07481263,0.015649237,0.026520541,0.038898516,0.07334023,0.022741795,0.068668686,0.0029015022,0.0256071,0.06464283,0.023240032,0.03466537,-0.063723564,0.00977307,-0.035941985,-0.028400557,-0.06862058,0.04773313,-0.021751933,-0.0043072905,-0.014810195,0.025225798,0.031178018,0.017226335,-0.032718055,0.08190386,-0.03258925,0.013981108,0.008646725,0.041568503,-0.072084405,-0.022389377,0.02023908,-0.037512723,0.038425397,0.0015199707,0.01700047,0.056226496,0.051811293,0.11315798,-0.08454287,0.08943992,-0.01807094,-0.030153481,0.015412878,-0.024686996,0.0823487,0.022028398,-0.08431644,0.007071466,-0.00189196,0.015900735,0.07149738,0.007177713,0.00014412546,0.03736848,-0.07245189,-0.00021902237,-0.07417913,-0.017171761,0.033606265,-0.08271017,-0.06471114,0.029951729,0.013535402,-0.031896207,-0.05445016,0.0042291004,0.02799029,0.12720674,0.021603301,0.020419026,-0.008759683,-0.047463235,-0.04255869,0.049678974,0.0025714354,-4.1531795e-08,0.04109561,-0.029750189,-0.049207263,-0.085594915,-0.07880718,-0.0056234705,0.015985526,0.032725543,-0.008919436,0.00068769214,-0.04838477,-0.018583348,-0.006199498,-0.001953011,-0.002729545,0.08241341,-0.036713168,0.06019122,-0.03525371,-0.031298067,-0.04786434,-0.06305817,-0.058591127,0.03876277,-0.035093553,-0.06060682,-0.018076513,0.08941989,-0.03423324,-0.028929032,0.013345846,0.0016007706,-0.06492851,-0.07558403,-0.024710031,0.06649128,-0.036037028,-0.04862532,-0.07411593,0.019410733,0.035923023,-0.0144627355,-0.010117301,0.0050282385,-0.0074880235,-0.028606337,0.005665222,-0.007534028,0.044647474,0.003984959,-0.008694869,0.032383554,0.008756046,-0.13220778,-0.13706645,0.05205486,-0.040988825,-0.02667184,0.020978218,0.007952384,0.009535674,0.0057246825,0.14337245,-0.06387131 +3.11.1.3,"Highly specific for phosphonopyruvate as substrate [2]. The reaction is not inhibited by phosphate but is inhibited by the phosphonates phosphonoformic acid, hydroxymethylphosphonic acid and 3-phosphonopropanoic acid [2]. The enzyme is activated by the divalent cations Co2+, Mg2+ and Mn2+. This enzyme is a member of the phosphoenolpyruvate mutase/isocitrate lyase superfamily [3].",384,1.0,-0.07448533,-0.01771148,-0.04885002,-0.083148405,0.04324811,0.063037775,-0.016092962,-0.020848248,-0.028101072,0.07467732,-0.010817186,-0.007910495,-0.049939346,0.025912678,-0.012446156,0.03033569,-0.011984471,-0.009773329,0.040137712,-0.038878936,0.13253282,0.058030963,0.025889324,-0.024974432,0.11081749,-0.013333871,0.081382364,-0.027356682,-0.0049659396,0.032626126,-0.08952861,-0.01588426,0.09573866,-0.1217908,-0.003221482,0.13833097,-0.081182614,-0.094623014,-0.0054636877,0.0038546752,0.042578835,0.022910697,-0.0059444755,-0.036264274,-0.096194744,-0.010516712,-0.012257886,0.0014827518,-0.014522216,0.00097181695,-0.050412133,-0.06612038,-0.012512125,0.017307336,-0.05886428,0.024664734,-0.02164526,0.08713574,-0.01695028,-0.022175271,-0.025659379,-0.014649546,0.039814536,0.015792891,0.04795063,0.016371015,0.03475903,-0.064543575,-0.012646221,-0.042123634,-0.0290886,-0.037886344,0.099012665,-0.05651366,-0.020921182,0.05535708,0.055346508,-0.0028411062,-0.02187436,0.0053181034,0.04827257,-0.05707217,0.025936065,-0.008116663,-0.007292152,0.024301024,-0.044733305,-0.008640466,0.041845847,0.026540507,-0.00314778,-0.0063773044,0.019620959,-0.044085346,-0.010378965,0.07503603,0.0026315872,-0.023117563,0.038836397,-0.022833934,0.035073794,0.11267963,-0.062256802,-0.055618558,-0.009035107,0.011094754,-0.06222084,0.028802747,-0.020900978,-0.0041154833,0.04489167,0.066187754,0.026929839,0.004995572,-0.014056881,0.030291516,0.03644507,-0.074943304,-0.06463624,0.051712327,0.07460403,-0.068058744,-0.013308974,-0.007471426,-0.10101463,0.040591553,-0.10141529,5.2688177e-33,0.059455812,-0.011176569,0.016271481,-0.09658397,0.0036381788,-0.021602038,-0.065795004,0.0041287285,-0.048244454,-0.05418584,-0.046237778,-0.046051256,0.08340217,-0.024342082,-0.05184548,0.0016354138,0.008119523,0.05963637,0.09773773,-0.0029532425,0.07922503,0.04008119,0.012013094,0.07766019,-0.0027628373,0.062420473,-0.048164092,-0.027478961,0.014607259,-0.009835264,0.04243369,-0.13562189,-0.049428184,-0.027630774,-0.01737273,-0.051977865,-0.13853946,-0.061042745,0.00011143879,-0.006800223,-0.042285014,-0.0039236057,0.0046662246,0.058643833,0.013379359,-0.0536424,-0.014295845,0.051292073,0.026946757,0.09352537,0.021295406,-0.020086342,0.0024932842,0.006824811,-0.06322924,0.007078678,0.021494808,-0.06803101,0.0053736945,0.02710787,0.03737491,0.020974057,0.049182277,0.010995207,-0.026213545,-0.03785916,-0.06568195,-0.14967993,-0.028930621,0.08021006,-0.027644329,-0.089446075,0.03735841,0.056736898,-0.020697322,-0.07559685,0.014932843,-0.0005067391,-0.04143744,0.019799672,0.06846783,-0.029862382,0.039641287,-0.017441912,-0.054126725,-0.050714955,-0.045303456,-0.056903828,0.021203205,0.006431814,-0.038865805,-0.0062167714,-0.0025401306,0.010435246,0.00082057266,-7.2589054e-33,0.16098431,-0.06536988,0.06853234,-0.13050182,-0.07203138,0.07964011,0.04857711,-0.035295278,-0.008933598,-0.017072834,0.009395928,-0.0050578928,0.03341022,0.0071085123,0.0083393315,0.0386438,0.059183303,0.071373016,0.029076688,0.0012397354,0.040397294,0.088081494,0.03474282,0.10133997,0.043626916,-0.0747104,-0.026244707,0.02355799,-0.02352986,0.091915965,-0.0576157,-0.0043235635,-0.056171186,-0.03604204,0.0025414552,0.040632583,-0.05352433,-0.025397837,0.011893469,0.06267059,0.06022832,0.0724566,0.066716075,0.0027241178,-0.04835489,-0.016538259,-0.03380625,0.025892459,-0.052376274,-0.026410226,-0.007145093,0.048185676,-0.013731101,-0.005379083,0.08904502,0.065804586,-0.058064535,-0.01944276,-0.012834068,-0.031835172,0.013925073,-0.09003115,0.007082802,-0.009766446,0.06731741,0.087249406,0.0676326,-0.020324802,0.017851954,0.029501846,0.033762444,0.02820917,-0.011472679,0.054287545,-0.05685897,-0.022896405,-0.103608325,-0.0303166,0.011123252,-0.055293836,0.079526,0.041792236,0.0117763,-0.074056804,-0.0076428163,-0.06623073,0.019473296,0.07251251,0.009828563,-0.011800381,-0.015837226,-0.059168413,-0.045972962,-0.0006218918,0.10900129,-4.2416666e-08,0.05117274,-0.019932779,0.034270912,-0.047463473,-0.04835421,-0.026619505,0.04069136,-0.049972676,0.030565247,-0.011466147,0.034355205,-0.01001276,0.088593915,-0.013385239,0.07376303,0.013556065,-0.034217816,0.13790505,-0.061495736,-0.029266313,-0.018764103,-0.024147747,-0.11760063,0.02999718,0.03887095,0.0076961084,0.06797602,0.034456246,0.014388726,-0.031809766,-0.0416987,0.003784254,-0.01642125,-0.05136499,-0.044527255,0.03548259,-0.024721403,-0.023001483,-0.05555756,0.033090964,-0.10276616,-0.039828748,0.020931784,0.0613896,-0.03675216,0.048871383,0.042738453,0.043201603,0.0021404463,0.030585986,0.059818856,-0.022815635,-0.04146826,-0.07672742,-0.07204781,-0.009877244,0.0074290233,-0.05166955,-0.06247618,-0.044117887,0.04979953,0.03614021,0.140396,-0.11031762 +4.1.3.40,This enzyme catalyses the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria [1]. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine [3].,384,1.0,-0.04515498,-0.0069089555,-0.103410386,0.003094485,-0.014090385,0.022111628,-0.032313652,-0.012988285,0.0024950497,-0.032349017,0.0128499,-0.024416866,-0.023089575,-0.011774167,-0.057239007,0.031936925,-0.043216128,0.029135792,0.015084018,-0.037960958,0.055083886,-0.015399172,0.00031016368,2.2237182e-05,0.049811944,-0.040124916,0.057926975,-0.030874643,-0.054625433,-0.07316589,0.035918828,-0.08160818,0.096127,-0.10162409,-0.004921095,0.07142555,0.0099093225,-0.014131892,0.08108485,0.009191509,-0.0060248254,-0.061883982,-0.015341161,0.1036833,0.03743734,0.017804187,0.007501035,0.060026217,0.08740646,0.007724883,-0.07660675,0.065473124,0.024727432,0.004294775,0.036278598,0.09722524,-0.03309892,0.027555626,0.0065314504,-0.022173736,0.012058801,0.007710757,0.076001704,-0.03537704,0.0044407607,-0.009467654,-0.017919803,-0.020232096,0.031104695,-0.008056846,-0.01486307,-0.07991404,-0.097753204,-0.0060188617,-0.06046916,0.10977984,-0.030462326,-0.032314144,0.032799844,-0.012898795,0.008435533,-0.04341555,0.06270462,0.058734436,0.04857417,0.0079444535,0.05761948,0.0010104112,0.08549481,0.08204585,-0.0024277032,-0.043412734,-0.01151148,-0.019958641,-0.03159774,0.009258831,0.050475165,0.09375841,0.014299658,-0.025340764,0.04551075,0.031780615,-0.022287149,-0.08900057,-0.019229865,0.042442236,0.046998665,0.09403332,0.018756768,-0.011300686,-0.0126337735,-0.014039834,-0.017185882,-0.06744263,-0.034168106,0.05591641,0.05673601,-0.024074877,-0.08675997,-0.00072847994,-0.027353894,0.08177241,-0.017950507,0.040898647,-0.079552755,-0.0318525,-0.050185863,3.97734e-33,0.048411082,0.094572194,-0.036615316,-0.027160784,-0.011902505,0.00916057,-0.095366284,-0.012039626,-0.08808034,-0.05983587,0.030427812,-0.05125119,0.025391603,0.05778413,-0.008030469,-0.01573353,0.037445962,-0.057425708,0.053506363,-0.006123962,-0.072171174,-0.012340545,-0.05512123,-0.08578693,-0.010482142,0.036371615,-0.019812103,0.040890966,-0.024859447,-0.005289401,-0.057948098,-0.06776887,-0.07701927,0.021522757,0.02627777,-0.030617865,-0.07993837,-0.013306379,-0.019439038,0.03712118,-0.0005282566,0.06896341,-0.0562405,-0.034907047,0.074260585,0.025807533,0.015391384,0.12047349,0.02227316,0.030296793,0.015123825,0.03770512,0.080714494,-0.009689916,-0.058651064,0.012271895,0.02852648,0.016709292,0.031501647,0.03619675,-0.06951445,0.033531938,-0.035388906,0.043241195,-0.03750886,-0.016911369,-0.014682002,-0.009839669,-0.05154466,0.05719083,-0.0556959,-0.052978843,-0.009022803,0.027510988,-0.0072317836,0.01462455,-0.07476238,-0.04524534,0.050751805,-0.087765396,-0.05454046,-0.030662699,-0.024720961,-0.024603043,0.0139827505,0.08341908,-0.038995042,-0.028507654,-0.044976376,0.06192025,0.03154245,-0.050693706,-0.023089461,0.06841629,0.062489975,-4.8820587e-33,0.05935849,-0.076078594,0.023367574,-0.082694925,-0.06508409,0.08715226,-0.010469465,-0.067101344,0.018686999,0.031709343,0.039089777,-0.081642754,-0.002667128,-0.050809897,-0.03486284,-0.04464252,0.06483666,0.11358071,0.01179072,-0.034445785,0.058069345,0.102672584,-0.060901064,0.000506042,0.0301163,0.028193202,-0.007593807,0.11913891,0.057100628,0.054188624,-0.010361009,-0.022379737,-0.008660034,0.0037596358,-0.033922065,0.11702789,-0.017127085,0.04979307,0.104883924,-0.0015931054,0.007204577,0.02165471,-0.06374034,0.021197822,0.013482649,0.10981112,-0.06878695,0.08278061,-0.04188649,-0.0606941,0.05024279,-0.0046916334,-0.040003885,-0.04390542,0.009688454,0.03746598,0.05283105,-0.079954036,0.050398607,-0.07100493,-0.047010224,-0.0013803858,0.09111032,-0.00010640842,-0.030608796,0.07420414,-0.020416712,0.052953932,-0.0069412095,-0.02526085,0.08738566,0.047662273,-0.0017052059,0.0885668,0.009628437,0.0069261086,-0.020015515,-0.10265988,0.014387941,-0.055968788,0.005986671,-0.036948238,0.04102269,-0.025958868,-0.03546628,-0.040069707,0.0329387,0.05167343,-0.01727456,0.10522166,-0.031618107,0.043444812,-0.07637376,0.04331834,0.04970482,-3.3517715e-08,0.06425745,-0.06673449,0.048641235,-0.04474361,0.012961746,0.035122667,-0.00934164,0.040359475,0.053320423,-0.02735123,-0.0565124,0.056788363,0.036322396,0.010769543,0.044639353,0.027663467,0.045694206,-0.009804313,-0.010901637,-0.029556721,-0.04197382,0.04424015,-0.09056189,-0.014177053,0.021377673,-0.11787802,0.06511713,0.013871607,0.004623725,-0.046829186,-0.0080548655,0.004527675,-0.062413014,-0.04621708,-0.043965474,0.011889257,-0.10171306,-0.11096587,0.052910987,-0.07848484,-0.035200108,0.008075833,-0.038580388,0.03732719,-0.04056062,-0.011940941,0.009417898,0.0009294024,-0.039024487,-0.028432742,0.066902004,-0.058224235,0.06154779,-0.078656286,-0.089301564,0.066358946,-0.033541065,-0.060161434,-0.0056275097,-0.112641245,-0.016323857,-0.010790401,0.1936915,-0.099071026 +2.5.1.67,"Requires a divalent metal ion for activity, with Mg2+ being better than Mn2+ [1]. Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. The mechanism of its formation is similar to that of the early steps of {terp/squalphyto::squalene and phytoene biosynthesis}. Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums.",384,1.0,0.01087592,0.006913659,0.034935746,-0.0010202491,0.036325105,0.050623123,0.030484008,0.04955754,-0.0024808645,0.007570366,0.025234152,-0.032960474,0.045021396,-0.045561936,-0.060141418,0.05397445,-0.05847542,-0.008938276,0.04318848,0.06486399,0.071705356,0.007571979,-0.05006196,-0.022254787,0.024649924,0.07987479,-0.0067310464,0.011759877,0.053699955,0.0033085784,-0.04260353,0.12523915,0.0073304414,-0.087247476,-0.0035577712,0.09289954,-0.029221283,0.042150542,-0.0028997117,0.021043988,0.037278906,0.022264594,0.036017623,-0.028688367,-0.059024543,-0.019853523,0.10082416,0.0068060337,-0.06816134,0.0058271037,-0.045147136,-0.0057987906,-0.027405845,0.059233695,0.009879957,-0.06631791,-0.02932421,0.013460597,-0.01563799,-0.012968733,-0.0261058,-0.015991302,0.0076531484,-0.07266305,0.026923712,-0.08531227,-0.0035980605,-0.010003046,0.120056644,-0.057960354,-0.018597107,0.006028307,-0.0077045234,-0.036740914,-0.013216106,0.097160146,0.08432324,-0.050673805,0.019406404,-0.06890422,-0.03971648,-0.000907931,0.07500399,0.0073720207,0.034196373,0.01372782,0.037502337,0.03264657,-0.009176511,0.053197455,0.03788475,0.08315877,-0.023952855,-0.013580314,-0.13570906,0.11868153,0.0018689793,0.012818177,-0.01976759,-0.0009130461,0.04345134,0.016133541,-0.123099945,-0.056888666,0.011969567,-0.03859639,-0.018117143,-0.0026747847,-0.0023765399,-0.038685888,0.0135747455,0.02350536,-0.049486507,0.027691228,-0.03361964,0.017244736,-0.012147357,-0.12752315,0.018442854,0.0038070357,0.07205125,0.022390867,-0.045214407,0.034614906,-0.019885221,0.043055587,-0.05283984,5.2498716e-33,0.06522014,0.12874676,0.069863126,-0.049279626,-0.09786149,-0.07382263,-0.043497153,-0.0044376124,0.015251067,-0.02080898,-0.027505696,-0.05619688,0.0036240865,-0.026767105,-0.028856847,-0.098539025,-0.045104593,0.03515259,0.13291824,-0.029002504,-0.070388675,0.07816042,-0.08589376,-0.028845008,0.026831742,0.059166346,-0.0099845575,-0.017598012,0.06207985,-0.008424908,0.13699655,-0.048172005,-0.009041662,-0.008985854,0.031750534,-0.08856985,-0.033627693,-0.08590253,-0.07148174,-0.049485713,-0.03918234,-0.030189775,-0.048836682,0.07163779,0.025445778,-0.110607974,-0.09042169,0.015863746,0.030464904,-0.015339892,-0.014880733,0.043404624,0.19049495,0.020649089,-0.008357681,0.009838146,-0.033411846,-0.07367033,0.022342026,0.035073303,0.024773745,0.0049944827,-0.03810721,0.059606466,0.066205725,0.0042040623,0.015465507,-0.0142197255,0.015834197,0.0593834,0.021673273,-0.08499629,0.060762357,0.03333225,-0.009662521,0.0458789,0.015426377,0.0020919596,0.013705242,0.0126690585,0.05876145,-0.0338098,0.011924499,-0.07660667,-0.0850848,-0.007222707,-0.013243552,-0.033000033,0.04443404,0.04871942,0.014477711,-0.014366852,0.0019530271,-0.014443106,-0.07456674,-5.494488e-33,0.002164682,0.0010492455,-0.0041954652,-0.034331255,-0.0663292,0.009830451,-0.0072863046,-0.075968325,-0.056364052,-0.0103711095,0.0424218,-0.003234917,0.034615807,-0.05547022,-0.062145803,0.034426887,0.12630254,0.07371179,0.020188902,-0.020294957,-0.056023322,0.09626737,-0.03340816,0.050127495,-0.034796525,-0.0012298023,0.045602825,-0.00848953,-0.010357985,0.05289176,0.05872569,0.01247345,-0.026273856,-0.04699846,-0.017787399,-0.006523464,-0.08285387,-0.057714134,0.074326865,0.075676695,-0.017798014,-0.017241899,0.068006836,0.027423857,0.040250868,-0.038234692,-0.09329784,0.053017113,0.0963535,-0.0647067,-0.044170674,0.06279256,-0.011242504,-0.05723233,0.04817604,-0.04340565,-0.04645127,-0.02717187,0.08937845,-0.031383622,0.04384099,-0.094945095,-0.068722166,-0.03205768,0.0008235575,0.06326516,-0.048196483,-0.032001838,-0.01405759,0.030452305,0.015637185,0.11366817,0.09282922,-0.03183303,-0.056611784,0.045713656,0.09170765,-0.026785864,-0.019571764,-0.036190446,0.07212735,0.09368575,0.044431705,-0.10930654,-0.08208651,-0.07769498,-0.052170336,0.0912412,-0.029815359,-0.05668071,-0.0950444,-0.055043194,-0.009845548,0.07529465,0.049188804,-4.6920515e-08,0.019533057,-0.06189542,0.07331336,-0.08531462,-0.046081018,0.028113388,-0.024967324,-0.0832745,0.021384954,0.0005990271,-0.03012416,0.020581994,0.04698326,0.014548562,0.048976935,-0.047442842,0.04895047,0.011110326,-0.05585411,-0.048774302,-0.052432355,0.00021799897,-0.08932365,0.004516078,0.031706396,0.046583693,0.034065288,-0.00056530564,0.00061948685,-0.0034344331,0.04413166,0.020235624,0.054017287,0.0074790665,-0.04190597,0.07562509,-0.0476541,0.053326916,-0.048496895,0.00019065138,0.0043646176,-0.0029825515,-0.0080812145,0.05058485,-0.024882553,-0.0025096608,-0.011723803,0.044945754,-0.033908647,-0.029087309,0.014712712,-0.019839743,-0.0121704135,-0.06768383,-0.009439434,0.02538174,0.027934741,-0.030560493,-0.03388167,-0.059917517,-0.03299863,0.0066083013,0.09134177,0.03822441 +2.5.1.68,"Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate.",384,0.99999994,-0.08623085,-0.04597641,-0.009155744,-0.034875605,-0.02162616,-0.029622084,-5.6717363e-05,0.07261166,-0.03527741,0.027059864,0.010746288,-0.044308454,0.11488668,0.06170527,-0.03738519,0.009171032,0.042026307,0.03220396,0.04452776,0.0071752155,0.08281492,0.047651146,-0.022781929,-0.112846136,0.041619457,0.044109028,0.050334793,-0.023458084,0.04658714,-0.0721667,-0.0055957995,-0.01640463,0.06958712,-0.113536686,0.06601845,0.091497965,-0.041889332,0.011403182,0.083167054,0.016306255,0.05225307,-0.0072363373,0.078869,-0.048897374,0.027920794,-0.0490744,0.042482547,-0.00075408217,0.0021067616,0.005600916,-0.056567393,0.040611304,-0.05915726,-0.0057184123,0.06817123,0.017504422,-0.0801831,-0.0022275494,-0.012419512,-0.03062143,0.038765382,-0.020432424,-0.030724674,-0.04929841,0.040729754,-0.05036179,-0.01039124,0.0059888954,0.049360227,0.04216449,-0.008115542,-0.019046798,-0.007643927,-0.020693047,-0.043100066,0.017193163,0.04612413,-0.048863813,0.03763769,0.0036859731,-0.043354727,-0.02508614,0.058897298,0.013163818,0.027180452,-0.037791576,0.09003752,0.02703042,0.004661774,0.07702032,0.104587555,-0.009707701,0.007296425,0.0012636819,-0.05825202,0.0008005968,-0.0034606748,-0.018146517,-0.00238552,-0.001299818,-0.0073851864,0.010917394,0.010917656,-0.06315298,0.008058713,0.0019000499,-0.052042987,0.05353691,0.043254714,0.06834863,-0.0018314742,-0.015317143,-0.062343255,0.027287725,0.0025332444,0.091310754,0.074436426,-0.10274847,-0.059956443,-0.03818235,0.05830751,-0.0054462636,-0.031358883,0.023926688,-0.10611865,0.052812893,-0.041088223,2.8101063e-33,0.006715476,-0.014793679,-0.011341343,-0.0060114963,-0.02007248,0.017180117,-0.083155505,-0.04516723,0.00011893302,-0.08273589,-0.056078035,-0.07013826,0.023131566,0.1387394,-0.12184244,0.0049832207,-0.01886738,-0.03130103,0.12180665,0.053676967,-0.0036360628,0.079981364,-0.0119400015,-0.030011632,0.009179108,0.057226755,0.022855671,-0.053597294,0.018823251,-0.004711233,0.070204675,-0.12069241,-0.04369981,-0.02779276,0.066019505,-0.0067608175,-0.08586835,-0.071397446,0.0012183522,-0.02354523,-0.031733453,0.001587519,-0.06411575,0.015432142,0.07188983,-0.06718481,0.011093242,0.028617665,-0.08478384,0.015829185,0.09591862,0.010449419,0.0017429309,-0.012794804,-0.029719653,0.0015436726,-0.035562083,0.002575376,0.06932814,0.05492743,0.042798545,0.027490593,-0.006672482,0.107734576,0.053716894,-0.0012186887,-0.05100514,0.011770944,0.0051666587,0.024498058,0.00043628382,-0.0861737,0.07167692,0.060107358,-0.041123785,-0.0110689495,-0.02985235,0.004231005,0.0030262598,-0.023918724,0.0634803,0.04204167,-0.056501884,-0.07018206,-0.05484862,-0.0038562878,-0.031853594,-0.093944564,-0.019849986,0.018542364,0.022641039,-0.023799274,-0.061751034,0.06665165,-0.023919147,-4.812057e-33,0.11728893,-0.079427585,0.08882476,-0.09392745,-0.10804007,0.020070694,0.09997855,-0.09677318,0.043657,0.053200416,0.008011764,-0.004590315,0.016489636,-0.043323047,-0.023102487,0.008483832,0.036944605,0.0896229,-0.053561926,-0.06406237,-0.019305684,0.13158053,0.02063247,0.029496176,-0.011033241,0.019741556,-0.03359573,0.011163997,0.025783254,0.08634184,-0.010568252,0.020036751,-0.047499392,-0.102213,-0.07168308,0.04539345,-0.042429272,-0.050718024,0.014463757,-0.05889143,0.04154282,0.0640255,0.060157012,0.099497736,-0.0005646331,0.011743557,-0.03774322,-0.0022372731,-0.019550642,-0.076886706,-0.049862966,-0.0143061085,-0.020449257,-0.022812242,0.051526617,0.03651259,0.029856598,0.0037437975,0.07910379,-0.014433292,-0.027258065,-0.0595405,0.044285197,-0.12941274,0.06398097,0.115110055,0.029732302,0.042286105,0.03922705,0.00046620533,0.07112586,0.0746681,0.022501308,-0.011376104,-0.039188612,0.06654736,-0.034747053,-0.007094692,-0.017593138,-0.067338794,-0.015301063,0.009141642,-0.04954726,-0.080699965,0.010939972,-0.10543379,0.020082114,0.11694688,-0.02353409,0.0010976619,-0.007805877,-0.06266503,-0.058910735,0.06539549,0.043864336,-4.0207425e-08,-0.031942375,-0.075420655,0.06646183,-0.09483012,-0.04552195,0.07500064,-0.022566365,-0.07170923,0.059393346,-0.017694082,0.06566819,-0.00030595064,-0.013675482,0.008081162,0.0282382,0.07223483,-0.0437031,-0.036702562,-0.033651758,-0.085578986,-0.05636268,-0.030836688,-0.0776436,0.093171895,0.011763557,-0.0329872,0.009358194,0.083874665,-0.011171804,-0.06459712,0.051148944,0.017499402,-0.019439608,-0.058705118,-0.034257025,0.01732801,0.013249278,-0.048605837,0.018121943,-0.046483327,-0.006687852,-0.0046180924,-0.0042535365,0.030692657,-0.05721426,0.033882525,-0.05776635,0.049891688,-0.086555086,0.05216213,0.013752181,-0.032964937,-0.033987373,-0.026983902,-0.05772937,0.057252966,-0.016419694,-0.061793778,-0.0008879514,0.002213301,0.0017348955,0.0269582,0.07653121,-0.036506288 +2.5.1.69,"Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. When this enzyme is incubated with prenyl diphosphate and 3-methylbut-3-en-1-yl diphosphate, it also forms the regular monoterpene geranyl diphosphate [2]. The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67, chrysanthemyl diphosphate synthase) when prenyl diphosphate is the sole substrate.",384,0.99999994,-0.012183373,-0.04843523,0.03360966,-0.066127986,0.021268733,0.03131288,-0.07946576,0.021617431,0.036025625,0.021807227,0.076617874,-0.032119837,-0.050219648,-0.020892108,-0.032538433,0.024455965,-0.051145483,-0.018417617,0.06024438,0.010043806,0.09620401,0.03338842,-0.062113333,0.013179305,0.06500767,0.0134934,-0.014859072,0.021613587,0.042571273,-0.049689513,-0.040776595,0.026058262,-0.059747346,-0.08189346,-0.0351777,0.08437606,-0.03474586,-0.0004307044,0.092289254,0.039457317,0.11697489,-0.05516642,-0.012322098,-0.067072295,-0.05220721,0.016697397,0.003616379,0.0055987737,0.02969137,-0.008473084,-0.004721667,-0.08713664,-0.051562473,-0.0006859343,0.02342233,-0.054892145,0.022321174,-0.0019557439,-0.0075568645,0.0695227,0.035816897,0.0021628123,-0.026059773,-0.0506963,0.026575234,-0.055850513,-0.0028569242,0.004767307,0.05396155,-0.09005284,-0.13315949,-0.018687278,-0.02133783,0.059447195,-0.043600097,0.114040084,0.008612518,0.05923646,-0.0024944367,-0.06556931,0.009120915,0.07322845,0.014773231,0.09313016,0.019090949,0.024800207,-0.0013506884,0.086973004,0.026250066,-0.044698,0.023865685,0.011018283,-0.037111778,-0.046031635,-0.03780144,0.075147055,0.024032345,0.030835925,-0.02480375,-0.051933322,0.049460027,0.017989723,-0.07828771,-0.05359747,-0.020384068,0.026936086,-0.05476733,-0.029949537,0.059552472,-0.067750126,-0.04002782,-0.0076231654,0.0062711155,-0.021212865,-0.111159265,0.026006006,-0.029209957,-0.06386076,-0.03791422,-0.010645941,0.018775143,0.0124625275,0.085499026,0.04361533,-0.008368529,0.011181759,-0.081526436,5.6725636e-33,0.094215065,0.13013443,0.06013581,-0.04629135,-0.038378816,-0.019158022,-0.048547663,0.089065574,-0.09785365,0.001079029,-0.009697586,-0.06004852,0.030361803,0.043476272,-0.031006094,0.026182838,-0.003767379,0.03724086,0.025502143,-0.050548054,-0.025842631,0.071532436,-0.0776837,-0.0020964807,0.012627627,0.0072470848,-0.05075101,-0.023665145,0.030891987,-0.009735951,0.043207113,-0.112911694,-0.018892534,-0.017032884,0.05447443,-0.059563167,-0.026602598,-0.10906751,-0.06185397,-0.03958673,-0.003509786,0.03041703,0.018417902,0.020772398,0.0067627653,-0.07882614,-0.09210791,0.0014557638,0.037048187,-0.02392954,-0.01486388,0.032297764,0.14953472,0.033066247,-0.05698604,0.04678321,0.024626885,0.00075651903,0.00660989,0.018909274,0.03209313,0.015145238,-0.12720354,0.017016722,-0.010841141,0.08795567,-0.06754247,-0.011439219,0.05535976,0.11680928,0.020945884,0.023615012,-0.06496085,0.07839153,0.036157504,-0.0103278505,-0.034616243,-0.0072484068,-0.00660992,-0.009234693,0.001419329,-0.035353925,0.036452677,-0.076739125,-0.07705799,-0.03450965,0.008444329,-0.036598276,-0.009982359,0.025477475,0.053044345,-0.02439417,-0.070878066,-0.00905231,-0.04356991,-4.8665084e-33,0.080038235,-0.037936483,-0.041887455,-0.06367887,-0.039808348,0.043179575,0.058896393,0.019317454,-0.05102732,-0.029941477,0.087455995,-0.01638552,0.031569514,-0.02062763,0.0188765,0.046230134,0.011261441,0.047944944,0.07161237,-0.008805513,-0.002963068,0.12629642,0.05612745,0.040676214,-0.020604087,-0.028815843,0.019027341,0.046228364,-0.04443572,0.1068479,0.04514943,0.047559872,-0.033552706,-0.070809424,-0.057372652,0.00010007002,-0.08800004,-0.036330383,0.068455726,0.061251417,0.026140936,-0.0011430933,0.056598604,-0.01576519,0.059180006,0.010029904,-0.130763,0.098984346,0.016882334,-0.016646605,-0.014891994,0.017144557,0.039407983,0.04176747,0.041640423,-0.03977014,-0.023375435,0.030799119,0.025920544,-0.06115213,0.02675961,-0.07959237,-0.059356835,-0.0068424633,0.009845656,0.08153821,-0.03258193,-0.025635667,0.009820133,0.031117253,0.02432901,0.045019977,0.04971183,-0.020765075,-0.024109604,0.057531532,-0.003808492,-0.034792565,0.018967189,-0.013333993,-0.007993788,0.11345932,0.037449267,-0.07706624,-0.043768197,-0.034103632,-0.021878194,0.12571904,-0.06309609,0.020408772,-0.04772976,0.014678969,-0.034740455,0.06692037,0.09408249,-5.0233616e-08,0.11555294,-0.025791867,0.09435726,-0.0024057243,-0.081089124,0.013444078,0.002661897,-0.036791585,0.03516787,0.02423141,-0.0055582006,0.040268023,0.016838001,0.010766883,0.058061548,-0.014633385,0.04715038,0.05791497,-0.055848777,-0.05593307,0.0040297154,0.0035102598,-0.024244405,7.4682845e-05,0.038028568,-0.059966266,0.030606866,0.026915407,-0.001979349,-0.053365506,0.027000638,0.024753483,-0.015781509,-0.06428491,-0.06615634,0.1451955,-0.09145678,0.026469905,0.007999844,0.008914284,0.020783959,-0.05959743,-0.08128586,-0.010273685,0.02203474,0.013938801,0.06107789,0.011070726,0.013676962,-0.030649483,-0.018939763,0.0013274112,0.07498763,-0.070714824,-0.072458334,-0.0069636838,-0.027214663,0.0006528957,-0.024786737,-0.074206434,0.02356148,-0.012119982,0.19369487,0.028990636 +3.2.2.25,"The enzyme preferentially hydrolyses 3- and 7-methylpurine nucleosides, such as 3-methylxanthosine, 3-methyladenosine and 7-methylguanosine. Hydrolysis of 7-methylxanthosine to form 7-methylxanthine is the second step in the caffeine-biosynthesis pathway.",384,0.99999994,-0.003354634,-0.051965773,-0.07898462,0.04834946,0.045726325,0.051684294,-0.06200063,0.016857613,0.017786382,-0.017178904,-0.036285583,-0.076542296,-0.028183712,0.037807666,-0.015962232,0.014309939,-0.07209167,-0.000579185,0.05378155,-0.07750226,0.102936886,-0.044790942,0.037634995,0.046543624,0.07081181,0.054782797,0.06492344,-0.032285318,0.07296903,-0.056938406,-0.039792087,0.015484248,0.029317167,-0.03278783,0.059696414,0.13606404,0.017021634,-0.0028844667,0.008986484,0.08141846,0.018311199,-0.010829808,0.05337383,-0.0142313,-0.05841428,-0.055773277,0.02242631,-0.034156054,0.04089335,0.028451249,-0.058971927,-0.07594258,-0.014487575,0.0098011745,0.076169215,-0.0032087308,-0.035261344,-0.065024965,0.020190509,0.11501634,0.043735594,-0.053632546,-0.03718558,0.02639768,0.04377011,-0.05858207,0.0033460471,-0.025736663,0.043841895,-0.043921538,-0.06708858,-0.084465496,-0.00552917,-0.055727884,-0.04300122,0.001947954,0.028905129,-0.0007028161,0.0022083055,-0.06926756,-0.00039473196,-0.021214893,0.07483096,0.045970324,0.04956145,0.003822291,-0.011159605,0.03770353,0.02946618,0.09148104,0.00052428397,0.007169444,0.02664302,-0.008583881,0.021100972,0.013683656,0.013153136,0.010432526,0.012874726,-0.0051907566,0.020909332,0.103753395,-0.07521964,0.007926827,0.06333749,-0.0042054625,-0.057792,0.08717179,0.020377954,-0.001418757,-0.019142775,0.052451447,0.026953397,0.08005281,-0.04172328,0.07747007,0.0316273,-0.035797395,-0.018566849,-0.026542213,-0.0055680517,-0.035664193,0.068191096,-0.010263261,-0.067125015,-0.010625675,-0.052200295,4.4211187e-33,0.039305303,0.012878412,-0.025575176,-0.06346527,0.021394432,0.0107608745,-0.0082592685,0.05601005,-0.01689679,-0.014028147,-0.04936698,-0.07300241,0.028558843,0.030118605,-0.021348476,-0.118892394,-0.015281908,0.031827416,0.026539719,-0.041753925,0.042141262,0.07257047,-0.0346036,0.0089262035,0.0074378834,0.065898515,-0.057806395,0.09957825,0.07015877,-0.029345633,-0.02696869,-0.09097735,-0.0629155,0.03567327,-0.0018235334,0.007668726,-0.0030530533,-0.02341699,0.03012863,0.12989396,-0.040114827,-0.018549435,-0.012385638,-0.07783152,-0.022290101,-0.004466684,-0.052157942,0.026606387,0.022987697,0.059977893,0.005220101,-0.0001082715,0.110601805,-0.022277955,-0.052745014,-0.035260726,-0.042435065,-0.017837781,0.017300133,0.019877274,-0.009139946,-0.027766254,-0.017357672,-0.04551907,0.034175232,0.005015451,-0.06270822,-0.049204774,0.0014146633,0.010146641,-0.050720055,0.03430078,0.024830332,-0.0034785618,0.05661443,-0.03599822,-0.113858,0.008214197,-0.02849429,-0.044947766,-0.0044752415,0.025590526,0.019815616,0.036560267,-0.023683101,0.03970685,0.013224873,-0.08835622,-0.028181903,0.0031954397,-0.0312238,-0.017038811,-0.006281373,0.05295817,0.0008554511,-4.299603e-33,0.10436844,-0.06159915,0.016763868,-0.1065106,-0.066209964,0.042954978,0.027261456,-0.051230412,-0.0768357,-0.058112554,0.061391246,0.020691108,-0.008043791,-0.06310256,-0.081441544,0.016923785,0.021370854,0.075604826,-0.049960613,-0.026759777,-0.02599099,0.0702158,-0.062293995,0.043350283,0.07707402,0.025567098,0.048699893,-0.019195799,0.046542384,0.090761006,-0.071029276,-0.0024356432,-0.045997944,0.011529994,0.02522829,0.07558248,-0.088290356,0.032506425,0.0111903865,0.07765409,0.012767503,0.07577508,-0.011433224,0.021225477,0.06456957,0.044238288,-0.11044951,-0.021839654,-0.057239834,-0.019371921,0.037965205,-0.050118104,-0.01656271,0.083062336,-0.005676989,0.028288739,0.010074155,-0.007577448,0.055392377,-0.065020956,-0.036617715,-0.054009553,-0.043084566,-0.044376362,0.04491677,0.042566106,-0.1340311,0.10996808,0.043073643,-0.029179597,0.0732104,-0.015894283,0.016628576,0.09109863,-0.04863699,-0.054284908,-0.01431422,-0.063972734,-0.044930696,-0.059161093,0.06649379,0.032536812,0.01143011,-0.08223018,-0.051036175,-0.06041863,0.12763843,0.05107052,0.045467466,0.015748462,0.0125088375,-0.018938998,-0.062188514,0.068009675,0.05513927,-3.9731344e-08,-0.014257085,-0.1621998,0.027644984,0.032314625,0.0035038907,0.070985444,-0.003415033,-0.011831544,0.02519984,-0.05162786,-0.030197361,0.010802478,0.03580523,0.04236391,0.006304801,0.019807411,-0.02813715,0.08009992,0.024507554,-0.003044416,-0.11599359,-0.025653997,-0.04991663,0.061976627,0.056891717,-0.06578766,0.026964644,0.06517307,0.05994957,-0.00969937,-0.030298837,0.034750607,-0.0054951846,-0.033968236,-0.062487796,0.052672744,-0.0017905851,-0.04382603,-0.00052341487,-0.0133991195,-0.019333744,-0.07803323,-0.08065588,0.02441504,0.015248945,-0.017280389,-0.010098429,0.058214303,-0.0029615266,0.03274081,0.09606973,0.0027080707,0.068435475,-0.06534671,-0.027508581,-0.038980946,-0.07151127,-0.036585465,-0.053637307,-0.08173478,0.030094808,0.02859097,0.2161194,-0.09681141 +4.2.1.112,"This is a non-redox-active enzyme that contains two molybdopterin guanine dinucleotide (MGD) cofactors, a tungsten centre and a cubane type [4Fe-4S] cluster [2].The tungsten centre binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct hydrophobic pocket [2]. Ethylene cannot act as a substrate [1].",384,1.0,-0.08372003,-0.06491715,-0.06928392,0.02708807,0.12987031,0.0051598917,-0.005979687,0.015823528,-0.056225874,-0.07724772,0.023547335,-0.088109046,-0.06146067,0.012175602,-0.07023357,0.076616935,-0.06364125,-0.028016822,0.051931173,-0.01875462,-0.003434832,0.002544269,0.04721191,-0.05236991,0.010975968,0.07799901,0.07653645,-0.06212253,0.037064012,-0.054461427,0.042427033,-0.007518332,0.01708931,0.0146695785,0.023182,0.08403422,0.043636963,-0.010902785,-0.02952541,0.01403785,0.033398308,0.027200121,0.04893928,-0.036587317,-0.008540915,-0.032822967,-0.06358278,-0.0071453527,-0.04975583,-0.016817153,0.08212272,-0.07074894,-0.040734127,0.016882462,0.016988236,-0.03134944,-0.02588864,-0.047335774,0.030424595,0.05669169,0.18599254,-0.0079643745,0.02957676,0.033177562,0.021516247,-0.047936298,0.0343567,-0.027263215,0.024666192,-0.06476325,-0.023139207,-0.048381537,-0.028948687,0.015873503,-0.0076084253,0.012315758,0.0122914845,-0.066039436,0.13925219,0.015968334,-0.02931174,0.056877673,0.09686832,0.06091296,0.08677804,0.016667781,0.034846127,-0.0378073,0.011628658,-0.008323042,-0.05347606,0.030887242,-0.06568964,-0.034267314,-0.07419102,0.012322343,0.015317757,0.0052547785,-0.02879783,0.041946992,-0.011776871,0.15352403,-0.07168117,-0.07329564,-0.054646786,-0.055316243,0.021203978,0.059180755,0.050423197,0.02658371,-0.054101728,0.020669455,-0.0070483065,-0.00908825,-0.035273753,0.038955893,-0.029995704,-0.040621355,-0.008646817,0.0127724605,9.361585e-05,0.0038869567,-0.050181493,0.033362724,-0.03894336,0.013867465,-0.07543423,1.9608623e-33,0.07184626,-0.03429832,0.0014908585,-0.013293434,0.07572859,-0.029699856,-0.084488414,0.008591116,-0.12325502,-0.008825673,-0.01579799,-0.050641097,0.045096755,0.06434102,-0.004581799,-0.06145227,-0.036327172,-0.019048816,0.058627512,-0.07014126,-0.00029291015,0.058437638,-0.05886638,0.00058104325,0.029945325,-0.01701308,-0.03357674,0.026459146,0.115736365,0.003834506,-0.036487594,-0.07482128,-0.097717464,-0.0023488733,0.0097345365,-0.018521767,-0.029776655,-0.089013085,0.015211646,0.009569126,-0.0424741,0.013412351,0.02322949,-0.043657236,0.025789624,-0.035144124,-0.010868086,0.0483742,0.019736087,0.022312004,0.013879759,-0.03659514,0.07167741,0.014441295,-0.06948006,-0.0006061546,-0.044137705,0.0033794618,0.0032645387,0.011948172,0.030854294,0.014978517,-0.042153805,0.02080149,0.040571574,0.05500503,-0.0036768669,-0.043928634,0.06412928,0.023453493,-0.036024626,-0.0140047325,0.08828722,0.01348826,0.020113485,-0.09417901,0.018935842,-0.037121415,-0.01323425,0.036965337,-0.047034062,-0.0047058854,0.03426163,-0.081936106,-0.039106086,-0.047789834,-0.04694117,-0.043471538,0.025782742,0.045267,0.0555691,-0.033456676,-0.006390396,-0.0027834126,0.006783407,-2.2871684e-33,0.09021327,-0.080864064,0.012834505,-0.08833779,-0.028701482,0.056770995,0.084073536,0.020078478,0.021177009,-0.033786234,0.13433796,0.0017320829,0.052433062,-0.07524403,0.050374903,0.033564296,-0.0012036781,0.06714306,0.06484304,0.003812968,0.035948835,-0.0037344436,0.042943165,0.06200701,0.018449362,0.07304955,-0.0121250395,-0.041007515,0.0130039435,0.041579925,-0.0539743,0.0071942527,-0.031353056,-0.00063636864,-0.05556179,0.038076248,-0.017984834,-0.007802022,-0.082425125,-0.020354517,-0.027980397,0.044246677,-0.021329174,0.14880131,0.044867158,0.06630118,-0.035471994,0.030598942,-0.007943277,-0.077739686,-0.0092545105,-0.012224235,-0.04625604,0.019225167,0.0023167003,0.086040705,-0.014976199,-0.018677684,-0.0195321,0.042952597,0.053458758,-0.050438717,-0.019544931,0.0068951384,0.048710886,0.041253623,-0.021538269,0.12850541,0.009330419,-0.036090843,0.07229742,0.054579362,0.048040017,0.034974463,0.019839842,-0.06555438,0.028860109,-0.045149267,-0.07069791,-0.04840302,0.0695285,0.07184237,-0.064851485,-0.047616016,0.02521639,-0.037127156,0.025784904,0.09830489,-0.010233931,0.025963327,-0.02446292,0.009926196,-0.06532212,0.06439617,0.06118346,-4.7489248e-08,0.013951533,-0.07416592,0.07905042,-0.13768452,-0.02939838,0.038570255,0.055193692,-0.04347971,-0.003918534,-0.07847216,-0.00881051,0.08200823,-0.00425607,-0.047457825,0.061750025,0.005125103,-0.053964265,0.024216892,-0.061426364,-0.014922832,-0.041394062,0.015444846,-0.119655885,0.07497752,-0.076808706,0.017332725,0.08221398,0.085763864,0.0068142624,0.0025266074,-0.017961977,0.04967379,-0.034623995,0.030545034,-0.051893577,0.037963476,-0.05047432,-0.013732782,-0.11230221,-0.007860717,-0.016146254,-0.004646554,-0.009224114,-0.01137301,-0.018596066,0.0346163,-0.048081763,0.015559527,0.013053993,0.0654552,0.04794805,-0.019658284,0.027192302,-0.0022886419,-0.110538565,-0.04077426,-0.057036374,-0.08038226,-0.028243272,-0.05249423,0.020679792,-0.07113807,0.18003745,0.07032605 +4.2.3.27,"Requires Mg2+ or Mn2+ for activity. This enzyme is located in the chloroplast of isoprene-emitting plants, such as poplar and aspen, and may be activitated by light-dependent changes in chloroplast pH and Mg2+ concentration [2,8].",384,0.99999994,-0.052383613,-0.045625605,-0.013254227,0.027217666,0.1112086,-0.0018621045,-0.018500764,-0.002686517,0.014280854,-0.006083818,0.05177378,-9.56303e-05,-0.014171693,-0.004469494,0.0015983544,0.01804329,-0.05029694,0.04975104,0.014772726,-0.031625465,0.14162238,-0.018679952,-0.049908236,-0.04369075,0.037811566,-0.008005785,0.00052633474,-0.034945752,0.061046015,-0.047598988,-0.035093497,0.0033246323,0.11052726,-0.045946177,-0.008704587,0.10242586,-0.018351087,-0.07240862,0.010575724,-0.0019823972,0.003947533,0.008598622,0.044039976,-0.0801,-0.041933127,-0.04400721,0.08722745,-0.090606555,-0.012572243,0.020344932,0.0067749163,-0.06739928,-0.02696668,0.01907778,0.0022259676,0.029978577,-0.04828508,0.01635131,0.012551606,0.0025931166,0.046928808,-0.0033909758,-0.057563163,-0.0035540964,-0.001659407,0.008174133,0.0020040679,-0.027033325,0.04912985,-0.07382434,0.013475213,-0.01800609,-0.06471341,0.02822014,-0.034116004,0.015126678,0.055235926,-0.05533008,0.019434508,0.032179877,0.0024749488,0.03861147,0.029487396,0.07284485,0.051598318,0.0582772,0.016597154,0.061023332,0.029219918,0.017006062,0.06868141,0.050120894,-0.07939858,0.049331687,-0.03160796,0.09606686,-0.025001558,-0.023245746,-0.016291287,-0.028251609,0.024065625,0.028273972,-0.026638053,-0.046053015,-0.006756626,0.027715975,-0.049050074,0.009974929,0.02922844,0.06349742,0.072537854,0.034333285,0.027108183,0.040830065,0.029389039,0.02860962,0.032419086,-0.09503331,-0.033338357,0.0074438616,-0.032004252,0.022096124,-0.028413953,0.08105388,-0.023829574,0.04584464,-0.11825102,1.5056436e-33,-0.004659654,-0.014213377,0.0036015443,0.011541671,-0.076413065,-0.002726868,-0.009565906,-0.02282579,-0.019907229,-0.085171096,-0.10305804,-0.07611028,-0.027083969,0.027952606,-0.0029953015,-0.05502898,0.047416244,-0.021018282,0.054328,0.0001281361,-0.044327036,0.023030547,-0.08000793,0.014502207,0.04079352,0.09169101,0.058868386,-0.080300584,0.059772428,-0.017777447,0.0688543,-0.09919819,-0.03541593,0.058695193,0.10469767,0.002687037,-0.046357967,-0.0077975676,-0.061904583,0.032895286,-0.00703571,0.053245626,-0.029037872,0.037623968,0.07644634,-0.06357534,-0.051941697,0.11362631,0.10003721,0.047748704,0.04410742,0.050119877,-0.0029771903,0.009117911,-0.083459616,0.08468296,-0.0034993843,-0.017566668,0.05910098,0.02898228,-0.032165814,0.04225499,0.041283906,0.054003563,0.09241804,0.058043152,-0.11355017,-0.09448632,-0.020573316,0.06791107,-0.062928736,-0.11561163,0.003363551,0.04274743,0.022480328,-0.054186694,-0.0014293346,0.042470295,0.035543434,0.03242055,-0.0060233064,-0.042923853,0.015549402,-0.063369386,-0.113560215,-0.060191903,0.0010455211,-0.042672917,0.007453837,0.029016774,0.11212511,-0.0037645227,-0.050377686,0.037431717,-0.051662665,-3.4738312e-33,0.06234643,-0.09215832,0.10361745,-0.062887326,-0.09719367,0.07699021,-0.06703468,-0.13302173,0.00477708,0.07674598,0.048032444,0.028423842,-0.026632296,-0.019375032,0.014504941,-0.016191864,0.033764433,0.095007785,-0.028471619,0.0021528509,-0.06818832,0.099644005,0.05825376,0.046174813,0.0018859995,-0.0045433072,0.027342973,0.01808419,0.011697307,-0.015574514,-0.056553423,0.03985145,-0.06892082,-0.011861869,-0.034409538,0.0010222419,-0.048718233,-0.04488529,-0.003888242,0.08619141,-0.029134583,0.0021721371,0.018403927,0.045964006,-0.030216794,0.004113036,-0.024695685,0.026005728,-0.039713394,-0.06441125,-0.002210948,0.011843932,-0.04371484,-0.015029332,0.038326543,-0.0040073805,-0.045527805,0.030068783,0.05747433,-0.07161566,-0.005475913,-0.06779062,0.020047843,-0.037000597,-0.016283818,0.09130463,0.014464325,0.06269867,-0.032141577,0.04004272,0.026031747,0.056732744,0.10342057,-0.014682497,-0.07216248,0.024881417,-0.018819239,-0.031929918,-0.01199447,-0.13084307,-0.013869034,0.061808445,-0.037668668,-0.07116714,-0.017534167,-0.11504142,0.021094795,0.09306403,0.008913126,-0.011973708,-0.05964386,-0.016167985,-0.05132559,-0.0016807874,0.09577533,-3.8785917e-08,-0.09232414,-0.022064392,0.021899417,-0.0828712,-0.045275513,0.045281455,0.01647619,-0.024533855,0.05518163,0.02225561,-0.0229231,0.03224076,0.0021545559,-0.034491494,0.021116098,-0.0009199994,-0.0137725305,0.033663366,-0.02857401,0.031181874,-0.061389502,-0.036022246,-0.13616681,0.053724304,0.05627364,-0.0462461,0.060998872,0.10614217,0.010501114,0.012938529,0.05856387,0.034655433,-0.004161383,-0.048588797,-0.06099666,0.080161884,0.016343588,-0.015851008,-0.085968494,-0.016220616,-0.06160469,-0.0629158,0.042652544,-0.00045193033,-0.09145057,-0.019302482,0.030705003,0.064098485,0.0034495878,0.045684658,0.041531343,-0.08213186,-0.04158296,-0.07228961,-0.0841579,-0.015007561,0.027567951,-0.068052225,-0.053678874,-0.028132632,-0.007980875,0.0128898425,0.095804885,-0.024036191 +2.1.1.158,"The enzyme is specific for xanthosine, as XMP and xanthine cannot act as substrates [2,4]. The enzyme does not have N1- or N3- methylation activity [2]. This is the first methylation step in the production of caffeine. ",384,0.99999994,0.025009833,-0.09037404,-0.08256474,-0.041586667,0.05105426,0.02832817,0.013157378,0.0078044394,-0.02466073,-0.04780084,0.0017146561,-0.09756044,0.01041733,0.036586523,0.011072397,0.030289609,0.011123827,-0.08860878,0.0543946,0.012947697,0.074947745,-0.017579852,0.06662044,-0.025461338,0.006498051,0.07415678,0.020083182,-0.041088797,0.0654709,-0.029536197,-0.0309696,0.030551605,0.05386353,-0.025260324,0.010653732,0.099398464,0.041671865,-0.011967964,0.003163113,0.062006775,0.056205567,-0.025500992,0.014646402,-0.013046361,-0.0014736672,-0.04183934,0.05354122,-0.03797797,-0.016466707,0.030253636,-0.014210787,-0.05082583,0.022687534,0.02513306,0.050194997,-0.0019645086,-0.06647203,-0.0061959983,-0.04511658,0.09293279,0.04325644,0.021025805,-0.014402853,-0.00922251,0.12270191,-0.04491392,-0.039479483,-0.07183703,0.02987587,-0.0439691,-0.050540663,-0.07895509,-0.010990662,-0.039826185,-0.036728308,0.035254527,0.09667999,0.039028436,0.02104193,-0.09413064,-0.04955943,0.0038787632,0.05038878,0.03219967,-0.03438244,-0.010207037,-0.042697288,0.05060776,0.012635905,0.073418394,0.0122493245,0.03986599,-0.03658899,0.011518282,0.017692735,-0.026502606,0.0511142,0.036506608,0.040891204,-0.007342488,0.019172909,0.07609156,-0.05761057,0.03459658,-0.011926384,-0.033276886,-0.033259798,0.07250025,-0.043329403,-0.007444501,-0.0527477,-0.013185085,0.021877028,0.091728255,0.008965103,0.102989405,0.0064389925,-0.0073237796,-0.04720849,-0.014353732,-0.015266779,-0.036169805,0.037187476,0.016710691,-0.033149946,-0.009743066,-0.06307921,3.0233476e-34,0.022936633,0.020013258,0.016045416,-0.08745796,0.03193908,0.050001636,0.030846138,0.10316342,0.000867,0.01951033,0.013057126,-0.07154824,0.02542025,0.037677664,-0.020480094,-0.045435265,-0.020634044,0.0119250575,0.026211835,-0.043811582,0.06614983,0.000136375,-0.058895264,0.006958007,-0.09417032,0.096280195,0.014680958,0.043995343,0.005698408,-0.0320682,-0.052744348,-0.07599976,-0.053531107,0.05846493,-0.028558755,0.033405684,0.03734601,0.011084971,0.0072539947,0.06912274,-0.039777152,0.02153464,0.029716533,-0.06399429,-0.017967772,-0.05122806,-0.12757885,-0.02315812,0.039520774,0.018217675,-0.0015281913,-0.01394629,0.08396376,0.04048907,0.0131258005,-0.012497421,-0.07599566,0.057816993,-0.048367947,-0.018740661,-0.008390766,-0.048170988,-0.04217686,0.017662225,0.005273296,0.0076591405,-0.044548746,-0.08174053,-0.0123174405,0.07067562,-0.0415982,-0.007856572,0.051257733,-0.0042582415,0.101308845,-0.031061685,-0.117594704,0.0371332,0.0064487895,-0.035147313,0.015053254,0.013246218,0.032612998,-0.019158717,-0.12429258,0.009517296,0.07082862,-0.02064636,-0.01953905,0.016775746,-0.018800195,-0.022304468,-0.0022447624,0.04358199,-0.045596566,-9.5411515e-34,0.007225491,0.0039025946,0.04863688,-0.06845893,-0.05347114,0.07845637,0.025590712,-0.07534933,-0.043029115,-0.031969916,0.08181528,0.035709634,-0.0051308325,-0.03520127,-0.043808315,0.073943965,0.008119559,0.05888019,-0.03981669,-0.011657885,-0.015495457,0.052930467,-0.08898763,0.034586743,0.04996514,0.011755688,0.06865623,0.045539748,0.064907484,0.03206922,-0.08260027,0.044425897,-0.013512788,-0.0062715393,0.061439496,0.0042550014,-0.060750056,0.00310231,-0.04558689,0.058423612,0.05010668,0.09584382,0.025855195,0.08290255,0.03124346,0.07154187,-0.0822445,-0.053371813,-0.009810015,0.03337901,0.028027983,-0.047231857,-0.031943254,0.037106313,-0.0011887652,0.09804743,-0.025169138,0.049881518,-0.030043118,-0.018289976,-0.007918262,-0.01988412,-0.02071177,-0.05891465,0.07063038,-0.03181587,-0.08104019,0.087240174,0.07239904,-0.007046148,0.12789147,-0.022874244,0.0011620614,0.059182476,-0.086649835,0.010097912,0.00725709,-0.066234656,-0.034812,-0.099024,0.08665031,0.08282464,0.040402807,-0.061367515,-0.0051819514,0.021320129,0.105810836,0.0972212,0.025093276,-0.021825332,0.0026994294,-0.035742655,-0.080818176,0.033434797,0.1049765,-3.1797796e-08,-0.010648005,-0.117871895,-0.031556763,0.05602578,-0.071525075,0.07535187,0.0075347726,-0.112702735,0.02978368,0.022892352,-0.062485203,-0.021234222,0.017104162,0.057321776,-0.010593777,-0.060233716,0.0066335453,0.05924224,-0.018958392,-0.03125162,-0.103997245,-0.01853808,-0.052528616,-0.057995122,0.04375122,-0.12301952,-0.009295115,0.067788444,0.074225396,-0.032558125,-0.06761846,0.0440735,0.045285966,0.008616315,-0.029185943,0.048253868,-0.0019194242,-0.057152506,-0.009854763,-0.035788927,-0.0076371133,-0.0817821,-0.07031164,-0.0002473897,0.021564513,-0.0069757802,-0.00019782549,-0.03650508,-0.0018764724,0.003399896,0.018797018,0.038922485,0.08136351,-0.15687582,-0.06581101,0.07045966,-0.115184695,0.013886447,-0.033784017,-0.09448407,0.030023267,-0.010359235,0.098722905,-0.121231414 +2.1.1.159,"This is the third enzyme in the caffeine-biosynthesis pathway. This enzyme can also catalyse the conversion of paraxanthine into caffeine, although the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis [2,3]. ",384,1.0000001,-0.047865644,-0.07834747,-0.13410108,0.058628526,0.020817107,0.064549685,-0.04748729,0.021282172,0.016846087,-0.019754594,-0.027788376,-0.073256075,0.03407033,0.009191064,0.022081891,0.047882583,-0.074431606,-0.020587686,0.034137283,-0.09285579,0.08807011,-0.015702704,0.044584446,0.018390743,0.03771669,0.0724466,0.027197419,-0.068418205,0.02125055,0.0018841284,-0.031205643,0.01698946,-0.0258714,-0.024470834,0.023639556,0.083547,-0.047143977,0.0033311367,0.08703317,0.08867892,0.017406257,0.027837249,-0.035706237,-0.024275105,0.042438906,-0.031156307,0.01882592,-0.027868427,0.02206629,-0.0020715008,-0.053205486,0.0067405943,0.013790928,0.033498667,0.07552039,-0.0031389259,-0.023596289,-0.0071032606,0.066066846,0.07133995,0.0072561526,-0.07092111,-0.014776567,0.01647079,0.07565016,-0.018568708,-0.050379474,-0.040982913,0.019030163,-0.05438673,-0.08908415,-0.073894046,0.03200005,-0.072963044,-0.020776886,0.013916715,0.07987635,0.052419253,-0.02481515,-0.037044015,0.04385597,-0.020702625,0.04997604,0.0873847,0.03458121,0.0078034494,0.053976603,-0.034174286,-0.001401271,0.092962265,0.014381407,-0.027238635,0.005387873,0.029092545,-0.039640468,0.033272803,-0.011725203,-0.0006855895,0.034122493,-0.03582189,-0.028399281,0.04162033,-0.013191462,-0.05476559,0.032362998,0.009047977,-0.044424728,0.09087548,0.0593887,0.03699002,-0.03246706,0.0052987766,-0.001596738,0.101227656,-0.02268346,0.15135287,-0.0018612342,-0.05033555,0.0021731933,-0.025399378,0.035014678,-0.021150405,0.0060853153,0.005405515,0.008383657,-0.05206956,-0.08758983,3.1315162e-33,0.0522863,0.037744634,0.010149982,-0.054317735,0.028014276,0.008498825,-0.06584961,0.037703842,-0.04460811,-0.015830562,-0.046672776,-0.09365274,0.02997694,0.041760582,-0.035315834,-0.07982618,-0.034905326,0.010591316,0.028009936,-0.051562034,0.03543814,0.05412181,-0.0580566,0.0033466502,-0.06359896,0.04974782,0.013819767,0.027258137,0.012166695,-0.024472237,-0.029454378,-0.049725343,-0.050359614,0.040169284,-0.011177703,-0.03457555,0.039871708,-0.036468003,-0.028672006,0.15531987,-0.0379901,-0.008683817,-0.011524113,-0.031014068,0.017859424,-0.064973265,-0.017931536,-0.014494573,0.047071572,0.08993229,-0.023242583,-0.012618241,0.18704939,-0.011702589,-0.050405692,-0.046250317,-0.05859988,-0.003239403,0.07708117,-0.022519609,-0.013026381,-0.077295244,-0.040794354,-0.0043742387,0.016979499,0.008996499,-0.054486595,-0.032727323,0.013626509,0.02124566,-0.05800062,0.0688959,-0.0067283,-0.03166421,0.120198525,-0.025992304,-0.11200322,0.033268586,-0.017649865,-0.10006224,-0.047967426,-0.036986113,0.018605828,0.06163064,0.008676479,-0.010282629,-0.008562902,-0.0583876,-0.018185835,-0.0052766427,-0.057755478,-0.006920219,-0.03675235,0.052573755,0.045766704,-2.4889115e-33,0.09983754,-0.056371637,0.054485857,-0.078903586,-0.03715906,0.06936545,0.012862605,-0.09553399,-0.0064005754,0.020319393,0.051779386,0.02395664,0.09130746,-0.0915822,-0.075497225,-0.011173554,-0.003179581,0.03375728,-0.0837899,-0.06219378,0.027772836,0.0072128093,-0.04880555,-0.052087307,0.031171441,0.09551129,0.01166742,0.038754813,0.02581448,0.07851584,-0.08224432,-0.0031234152,-0.018391645,0.026287472,0.047702584,0.06869785,-0.026298303,0.008850267,-0.046379574,0.043549195,-0.018586945,0.06533296,0.030608118,0.01964141,0.058187276,0.034555033,-0.06369521,-0.035667133,-0.011395765,-0.0065475972,0.064760685,0.003488586,-0.029087856,0.038651854,0.021095918,0.032804385,-0.015797192,0.0019055996,0.060751386,-0.042344175,-0.03211384,-0.00049606577,0.02759629,-0.042097844,0.049964473,0.01079402,-0.087395705,0.06908175,0.04927176,0.013836263,0.15602441,0.039380446,-0.01097744,0.09633226,-0.015164911,0.0035913556,0.018298175,-0.09003257,-0.019123282,-0.01913434,0.07076429,0.019311735,0.039991613,-0.045273438,-0.09019653,-0.033715762,0.10564214,0.06211306,0.044965506,-0.022628063,-0.015479048,-0.028112391,-0.016319122,0.09237236,0.08058675,-3.3733162e-08,-0.03491003,-0.048553992,-0.03826263,0.07387006,-0.0012326322,0.057216715,0.016216824,-0.035017934,0.00669395,-0.07028539,-0.04409159,-0.050045554,0.04102153,0.037564818,0.04573683,-0.054931562,0.006338599,0.024299521,0.005853769,0.00023888751,-0.09106741,-0.07175323,-0.06951048,0.025485875,0.08513995,-0.09259759,0.010529921,0.007710663,0.03926811,-0.047977757,-0.04829727,0.02563727,-0.022261053,-0.025477504,-0.105952315,0.019471334,-0.043228928,-0.026250973,-0.011038446,-0.011559061,0.00563007,-0.12998842,-0.09126425,0.010784461,-0.026475886,-0.019553417,0.035430945,-0.02374657,-0.032100618,0.010389103,0.049080566,-0.006825649,0.06888126,-0.042109452,-0.06388888,0.013922564,-0.03969497,-0.015457491,-0.0479877,-0.11890269,0.04082504,0.027717425,0.18005385,-0.042277902 +2.1.1.160,"Paraxanthine is the best substrate for this enzyme but the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis [2,3].",384,0.99999994,-0.036434382,-0.09256949,-0.11587002,0.028227169,0.01076901,0.06298713,-0.07670387,0.05783894,-0.006630082,-0.039170742,-0.020716775,-0.02251531,0.01347376,0.053633858,0.014582168,0.07062349,0.034233518,-0.041044306,0.07270291,-0.07567002,0.06917339,-0.042171545,0.044614818,0.014156893,0.048988193,0.064692326,0.029222732,-0.029950576,0.04092039,-0.021971272,-0.042851318,0.024198368,-0.02208036,-0.042843398,-0.013997236,0.09996008,-0.06145537,-0.012834874,0.07888282,0.049694918,0.033674274,0.024789771,-0.019860245,-0.016990125,0.027382713,-0.04816831,0.05078503,-0.034300115,0.024544,0.03321881,-0.04153688,-0.006879857,0.031016333,0.036520608,0.060446206,-0.0105885565,-0.054367132,0.0057950793,0.070643306,0.07429319,-0.007764491,-0.06052422,-0.007402921,0.0075978334,0.053081047,0.016631028,-0.051297612,-0.027448252,0.029472873,-0.028564999,-0.109892644,-0.068372704,0.033156507,-0.048237465,-0.040366538,0.01609261,0.0950932,-0.0082777655,-0.024463573,-0.012990586,0.030297894,-0.0056680045,0.041605603,0.089032635,0.08086127,0.019679952,0.076439194,-0.029549522,-0.007729521,0.09716466,0.03082676,0.025499783,0.016746197,0.013189454,-0.025789758,0.042381562,-0.015941925,-0.010758221,0.0120549,-0.047271404,0.006885491,0.027723314,-0.031284522,-0.029559221,0.028276313,-0.020489136,-0.017538544,0.057879373,0.059813164,0.018655004,-0.028215623,0.04170403,-0.025728593,0.09621648,-0.014271529,0.11212101,0.03120755,-0.02694647,-0.014347569,-0.032927908,0.022163788,-0.008735318,0.0153253125,0.014506185,0.0089468695,-0.042076223,-0.08290554,1.626208e-33,0.0536255,0.041904606,0.00088864245,-0.044298545,0.024466367,0.012387872,-0.06067874,0.042497873,-0.034388866,-0.029117735,-0.07514058,-0.098301165,0.0050434833,0.049260758,0.005934453,-0.10942209,-0.046675365,0.028865531,0.017470835,-0.072184674,0.034606062,0.023705417,-0.05146523,0.008639921,-0.039370015,0.007597493,0.006947434,0.05673843,-0.029243082,-0.026258253,-0.0529864,-0.090054385,-0.026115045,0.03559026,-0.03752031,-0.039803147,-0.006921007,-0.018237578,-0.015492961,0.1114046,-0.026200926,0.05834606,0.027806226,-0.044746052,0.048648864,-0.08420721,-0.05000747,-0.0007952157,0.033519026,0.06621179,-0.017123386,-0.03670671,0.18097062,-0.034752045,-0.05763368,-0.03562922,-0.07802045,0.025674308,0.056027178,0.021009637,-0.03579317,-0.04976461,-0.049833387,0.005575993,0.010008603,0.031512257,-0.087197386,-0.0672136,-0.025590166,0.0044831424,-0.0026549876,0.054205146,0.042251334,-0.03665956,0.08558005,-0.040645715,-0.08122039,0.074475236,-0.018153807,-0.09046796,-0.021998925,-0.049914267,-0.036682386,0.046105664,-0.011523489,-0.039985314,0.00013023293,-0.03800428,0.002195023,0.015437064,-0.061288636,0.0056249923,-0.0018343726,0.051377267,0.01453989,-1.2321952e-33,0.12157987,-0.069575645,0.116295725,-0.037999157,-0.04182487,0.10910874,0.036118023,-0.09574929,0.009730076,0.036304187,0.027485503,0.047907285,0.05144673,-0.073052,-0.07690977,0.0146885365,-0.024155833,0.025283344,-0.0582943,-0.07217803,-0.004666731,0.06927143,-0.03718766,-0.038189746,0.07054154,0.06705131,-0.007525331,0.04042192,0.01813385,0.05878766,-0.1070666,0.03241884,-0.021103982,-0.0039680614,0.035520125,0.088603675,-0.03543143,0.00855316,-0.05148906,0.0723591,-0.008157248,0.09386845,-0.0074163703,0.049697664,0.0322357,0.014265882,-0.078295134,-0.060377013,-0.009920704,0.01345829,0.034764614,-0.015414755,-0.032566357,0.041204873,0.02045311,0.03986144,-0.032924235,0.016477551,0.026385428,-0.06778051,-0.031714648,0.015880343,-0.0018277614,-0.06759622,0.025825184,0.008575682,-0.07332414,0.098271675,0.016014056,0.0065273573,0.1401934,0.030094117,0.017710198,0.10394682,-0.04145005,0.012366331,0.026622452,-0.06917299,0.008399393,0.0046696602,0.06747349,0.050934948,-0.032107163,-0.032528695,-0.05556691,-0.0076467954,0.112529926,0.027890872,0.054172225,-0.027138563,-0.013501569,-0.054066256,-0.0346536,0.06315763,0.084131666,-3.06001e-08,-0.0038808328,-0.06537849,-0.037009414,0.064532764,-0.025517138,0.059441943,0.023474926,-0.042035434,0.0064494065,-0.06459894,-0.022423528,-0.037717562,0.04949445,0.042875793,0.026619315,-0.0600203,-0.004437396,0.020827375,-0.00821211,0.01164363,-0.0973311,-0.046927195,-0.089670874,0.030038374,0.07562212,-0.120759934,0.05275766,0.01705103,0.03282043,-0.0469538,-0.05898054,0.030773861,-0.05341682,-0.032706384,-0.09262704,0.037247796,-0.04587373,-0.006168381,-0.02772201,0.04828822,-0.0152758565,-0.13649592,-0.07058254,-0.00408859,0.0064195446,-0.031015348,0.038761694,-0.018139742,-0.033550248,0.022146547,0.035428796,-0.017071899,0.051367924,-0.07054227,-0.04284466,0.016204275,-0.05878079,-0.02981555,-0.07222152,-0.1381508,0.051555444,0.039510306,0.15618724,-0.04852786 +1.14.13.103,"A membrane-bound cytochrome P-450 heme-thiolate monooxygenase that is associated with the endoplasmic reticulum [1,2]. This enzyme is specific for sophoraflavanone B as substrate. NADPH cannot be replaced by NADH, FAD or FMN. Along with EC 2.5.1.70 (naringenin 8-dimethylallyltransferase) and EC 2.5.1.71 (leachianone G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway.",384,1.0,-0.0060603116,0.025940722,-0.08483219,-0.022877108,0.030226817,0.119305275,-0.08964489,0.089579076,0.03586173,-0.030354269,-0.04326057,-0.032754034,-0.03066394,0.020748727,-0.043717694,-0.011862869,-0.086815536,-0.011948538,-0.06893221,-0.09176891,0.07869486,0.023145389,0.06607997,-0.04189056,0.034222186,-0.007888963,-0.0040720017,-0.040481754,-0.055387523,-0.08455384,-0.0024881465,0.013752621,-0.024392493,-0.0270615,-0.0023587737,0.13966817,-0.030329911,0.027233873,0.0017813027,-0.009685323,0.0036953345,-0.04943212,-0.08171121,0.032313645,-0.009906408,0.001698095,-0.0010552407,0.03220678,0.002864305,0.037947193,-0.04543671,-0.033959776,0.00048331282,0.03111178,0.08302628,0.061968382,0.041371845,-0.014024973,-0.038115773,0.025730545,-0.012943276,-0.05328029,0.016306635,0.021823995,0.009736673,-0.04400318,0.027441463,-0.08984031,-0.04181655,-0.06933082,-0.068691246,-0.05830652,-0.07952518,-0.0036428557,-0.07184589,0.12939762,-0.09734411,0.050036076,-0.007423931,0.017753454,0.12661532,0.008850394,0.044000007,0.08917784,0.05663252,-0.038202688,-0.018540215,0.015606986,-0.00940328,0.087683514,0.00044339852,-0.024632605,0.030066933,0.021237265,-0.1047829,0.032973886,0.044470694,-0.017319994,-0.011390539,-0.048206665,0.016014867,0.0080824485,0.024098914,-0.036789842,-0.02058992,-0.04818825,-0.03666305,0.08690953,0.052602198,-0.068792164,0.031227734,-0.077670254,0.04030679,-0.03272703,0.006292476,0.10699418,0.0035848692,-0.0017926401,-0.04979074,0.0050400347,-0.04323536,0.04487261,0.021345282,0.08557921,0.0007605557,0.042161904,-0.1451061,5.544692e-33,0.08666089,0.033114307,-0.042748623,0.0044468925,0.012149894,-0.0005438909,-0.017183658,0.06172836,0.025474532,-0.053502504,-0.056155887,-0.045966174,-0.015282947,-0.049092613,0.0071210214,0.00084334624,-0.09242222,-0.018829655,0.015166635,-0.075660765,-0.002233667,-0.005572936,-0.03942043,-0.025182284,0.043790676,0.052158613,-0.065236,0.02538012,0.042441264,0.007595877,0.017559137,-0.10998997,-0.06552671,0.00066067046,0.03190003,-0.078112036,-0.047869075,-0.0295214,-0.09425742,0.04454506,-0.08052709,-0.008695325,-0.011944653,-0.063676536,0.06314553,-0.107176356,-0.06037173,0.09438708,0.031827662,0.060383357,0.0027620357,0.004287816,0.116804756,0.023380099,-0.057201535,0.006323393,0.002856082,0.029699378,-0.0026311302,0.10032337,0.10916176,0.09655946,-0.006211275,0.04951865,0.029144865,0.03231799,-0.04443628,-0.046092097,-0.036364518,0.10498726,0.036471643,-0.021118293,0.098141946,0.028764267,0.016930718,-0.009322934,-0.028708134,0.029161032,0.036931243,-0.038151305,0.043098014,-0.018725734,-0.031849787,-0.04039899,-0.007871642,-0.009445419,0.044757422,-0.075086996,-0.045485437,0.04009534,0.029466037,-0.05615507,0.007999107,0.020833286,-0.0002536144,-5.173172e-33,0.08326577,-0.049117677,0.029520739,-0.106046945,-0.023254821,0.12335274,0.026179086,-0.013841297,-0.036532927,0.0011646494,0.040488377,0.015493057,0.04527471,-0.000563374,0.01892737,-0.08142825,0.020604702,0.005569275,-0.005687493,-0.001341077,0.017301673,0.04408599,-0.050746698,0.06842567,0.05069521,-0.0038089505,0.038093325,0.011406518,-0.029514242,0.05710602,-0.059915714,0.047442798,-0.10434188,-0.029901853,-0.005918351,0.012329598,-0.02823812,0.010045056,-0.0017232882,0.055918947,-0.04882394,-0.010855333,-0.0043770405,0.028039334,0.058920763,0.0374772,-0.13752893,0.007895541,0.078866206,-0.105304815,-0.008447267,0.03350234,-0.0017312753,0.024775257,-0.034150783,0.005390787,0.028508851,0.0022841068,0.03384057,-0.10507052,-0.0145424185,-0.057863474,0.037025813,0.018838279,0.053652763,0.045220044,-0.019317022,0.0101905465,0.0011916799,0.03271405,0.04106739,-0.062177595,0.07302606,0.08303703,-0.029866507,-0.0010910355,0.0058062444,-0.012509877,0.05649224,-0.03255609,0.020112393,0.03714755,-0.005415062,-0.06164057,0.030637654,-0.108595565,0.0059285085,0.06483072,0.0097270245,0.014029387,-0.009066361,0.063352436,-0.082384914,0.028760051,0.036738753,-4.5882864e-08,0.04224946,-0.06358679,0.023616442,-0.0031563472,0.103735566,0.01061981,0.05858996,0.007475192,0.035113968,-0.020054014,-0.02757564,0.09030041,0.019559171,0.039127335,0.049828354,0.011046613,-0.0033787843,0.048788488,0.038887836,-0.030199653,-0.06956424,-0.046711884,-0.07043445,-0.010276599,0.05497784,-0.091979735,0.0036768515,0.002757523,0.06916592,-0.03152556,-0.004822382,-0.00492539,0.008690013,3.6517926e-05,-0.03743669,0.0039360183,-0.056706622,-0.0013843992,-0.09135995,0.037236016,-0.052147325,-0.057190582,0.032060422,0.038172357,0.04263964,-0.0014071533,0.09717307,0.047921717,-0.017169181,0.036031928,0.017214729,-0.01811414,0.013717397,-0.061145842,-0.12119348,-0.0018958452,0.023387631,-0.043384247,-0.044628024,-0.03223213,-0.009792035,0.06275359,0.18845773,-0.06792551 +2.5.1.70,"Requires Mg2+. This membrane-bound protein is located in the plastids [2]. In addition to naringenin, the enzyme can prenylate several other flavanones at the C-8 position, but more slowly. Along with EC 1.14.14.142 (8-dimethylallylnaringenin 2'-hydroxylase) and EC 2.5.1.71 (leachianone-G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway.",384,1.0,-0.035811126,-0.024303176,-0.07927629,0.017429799,0.042054906,0.058809154,-0.065184675,0.07084785,0.021879531,-0.075564265,0.015116195,-0.058567237,-0.018512564,-0.008271885,-0.050815172,-0.031191617,-0.05094174,0.01953134,-0.09547781,-0.044737387,0.14264156,-0.012634621,0.04849872,-0.03060231,0.020392423,-0.0124363415,0.06912167,-0.12514295,-0.020656891,-0.07953673,0.038961742,-0.021485297,-0.00019725869,-0.052151024,0.0047638477,0.08841744,-0.018795442,0.015859848,0.052936792,0.030570976,0.025927695,-0.06793057,0.047281582,-0.04538068,0.045336206,-0.06057856,0.026333861,0.04078184,0.04267214,0.088545844,-0.07397639,-0.039326344,-0.03145559,0.03515682,0.09120698,0.05701984,-0.099795744,-0.027222395,-0.024322,0.06645659,0.061999768,-0.05830981,0.02432724,0.0069000493,-0.016213989,-0.02865662,0.045352206,-0.053897638,0.018836284,-0.03695285,0.022390444,-0.051511597,-0.036327712,0.022882005,-0.028342845,0.093668714,0.02453188,0.054473672,-0.0012501815,0.02104445,0.08746295,-0.003239194,0.09457241,0.09203453,0.02830515,-0.0311366,0.010286207,0.014734829,0.025372121,0.14806387,0.037321392,0.041768923,0.006251157,0.004099477,-0.046842452,0.025587004,0.008671755,-0.008280197,-0.06912761,-0.0032120137,-0.008415779,-0.03978134,0.060687203,0.028259527,-0.054282486,-0.014373487,-0.040428925,0.024446214,0.019799747,0.001790004,0.093079954,-0.029453535,0.03907818,-0.017286954,0.0011234389,0.10971128,-0.043273773,-0.03749635,-0.04585637,0.019461557,-0.033773854,0.030226529,0.03052623,0.060298648,-0.04231096,0.054373626,-0.1530511,4.3224275e-33,0.057094734,0.054193236,-0.019665234,-0.029814549,-0.057826325,-0.067912005,-0.06373828,0.027396515,-0.019835502,-0.08582795,-0.08034847,-0.0391772,-0.041409586,-0.0022685,-0.021353178,-0.07062752,-0.0022693982,-0.03233888,0.0323651,-0.08519049,0.012211608,0.0012968867,-0.019577237,-0.03820599,0.018222347,0.055273227,-0.0256095,-0.04571314,0.051050365,0.00074765435,0.036022868,-0.11870023,-0.029339146,0.04454714,0.063086644,-0.06541407,-0.046373326,-0.07765052,-0.04114923,0.0622092,-0.01935427,-0.005751445,-0.008256301,0.04440565,0.04340766,-0.081762746,-0.09333112,0.075621456,0.06021681,0.07048059,0.04499561,0.052722726,0.07544866,0.10174575,-0.05316377,-0.011968424,-0.047258083,-0.006009943,0.06009169,0.024481932,0.04388665,0.06163634,0.015834661,-0.008131371,0.022374185,0.050524525,-0.0750998,-0.033352222,-0.0031382034,0.016245829,0.014067194,-0.06715928,0.1061282,0.05840098,0.09741701,-0.007387229,-0.029801957,0.047436047,0.020148076,0.0062856446,0.00960665,0.0053257057,-0.013747369,0.0037747936,-0.061117116,-0.0063864705,-0.017324334,-0.043514583,-0.010306373,-0.0063576563,0.027732996,-0.062417857,-0.045500677,0.049422078,-0.025052926,-3.9076837e-33,0.08503964,-0.07985008,0.05739154,-0.039950278,-0.029661633,0.057171114,0.025646793,-0.0910413,-0.03960246,-0.009993632,0.023196865,-0.0045365426,0.02330574,-0.057321392,0.025005044,-0.015012921,0.04987239,0.051973425,-0.0041793194,-0.06322328,0.01007153,0.036935933,-0.06505356,0.075508,0.000961708,-0.010905042,0.03891497,-0.011964657,-0.0050817393,0.09970453,-0.02968127,0.03041154,-0.09349173,-0.022690566,-0.04961387,0.073887,-0.03344967,0.0040004323,-0.039059196,0.041457634,-0.02144291,-0.03495888,-0.012881084,0.051154368,0.038463015,0.075316064,-0.046733513,0.0048445445,-0.021658024,-0.01890915,0.055118613,0.0730935,0.0027337451,-0.013661787,1.1023252e-05,0.021357358,0.036551844,-0.0056603113,0.02816163,-0.061827663,0.0038926401,-0.10162559,0.032043185,-0.054818142,0.04868071,0.091572344,-0.0072562327,0.060232423,-0.024655106,0.01424355,0.0496002,-0.08846399,0.07943656,0.06240237,0.0031632322,0.045438524,-0.00807084,-0.017186116,0.042008173,-0.06249441,-0.007264411,0.013464769,0.0447583,-0.06370245,0.028865715,-0.053638067,0.10237742,-0.018262435,0.036286972,0.070602156,-0.029631535,-0.026050791,-0.09476114,0.05015787,0.041781608,-4.9107967e-08,0.034179915,-0.08941517,0.033994667,-0.029248266,0.08454969,0.046500385,-0.022280836,-0.0042827553,0.007955536,-0.068551354,-0.0716683,0.064599134,-0.0040656826,0.015212607,0.06874239,-0.022043284,0.022049488,0.080107644,-0.030996906,-0.047567412,-0.06755805,-0.026195176,-0.10822852,-0.046799656,0.011416792,-0.0979947,-0.021684308,0.078883,-0.0071892394,0.0002668021,0.03342611,0.0046240743,0.006712956,-0.03000463,-0.08773209,0.006404549,-0.022292217,-0.0008700674,-0.05258798,-0.01073313,-0.081944294,-0.047074724,0.105144076,0.03558553,-0.010151692,-0.008531357,0.031214233,0.059792507,-0.0005268907,0.053635888,0.017306183,-0.017676843,-0.033456787,-0.043079764,-0.09618109,-0.06544217,0.02487211,-0.066584066,-0.03384436,-0.012027464,-0.06706788,0.032084282,0.16957377,-0.05693144 +2.5.1.71,"This membrane-bound enzyme is located in the plastids and requires Mg2+ for activity. The reaction forms the lavandulyl sidechain of sophoraflavanone G by transferring a prenyl group to the 2'' position of another prenyl group attached at position 8 of leachianone G. The enzyme is specific for prenyl diphosphate as the prenyl donor, as it cannot be replaced by isopentenyl diphosphate or geranyl diphosphate. Euchrenone a7 (a 5-deoxy derivative of leachianone G) and kenusanone I (a 7-methoxy derivative of leachianone G) can also act as substrates, but more slowly. Along with EC 1.14.14.142 (8-dimethylallylnaringenin 2'-hydroxylase) and EC 2.5.1.70 (naringenin 8-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway.",384,1.0,-0.07055152,-0.038630143,0.030514976,-0.05541312,0.03076891,0.071006335,-0.05903742,0.06528929,0.012886571,0.00438567,0.051389404,-0.07140218,-0.053067163,0.044511143,-0.045453154,0.0033746664,-0.028069204,0.028013669,-0.058484904,-0.018405335,0.123967975,-0.054537047,-0.022282591,-0.054234885,0.035184916,0.046978835,0.056941103,-0.03418411,-0.023933245,-0.06743111,-0.04139653,-0.062497977,-0.011775761,-0.025207967,-0.045141343,0.1082035,-0.05838527,0.023092046,0.024759902,0.0845805,0.045985617,-0.07032516,-0.042061143,-0.03498384,-0.02705032,-0.055749804,0.030034032,0.021533571,-0.016212497,0.041506965,0.018843718,-0.011023544,0.0071191844,-0.029217478,0.030855704,-0.0024979257,-0.047196195,0.026609287,-0.036772486,0.026533563,0.067523964,-0.05311949,-0.00081357645,-0.039006498,0.0070387674,-0.05416146,0.04634998,-0.058322545,0.010445025,-0.04239745,-0.005784843,-0.021983257,-0.01407028,-0.008699679,0.021958182,0.1017555,-0.0069957925,0.028179957,0.005331859,-0.050197426,0.08810406,0.03942984,0.04153318,0.07592687,0.022031462,0.00028102874,-0.008346314,0.039602093,0.073578335,0.08115483,0.06443998,0.013798593,-0.033919998,0.031090813,-0.03998462,0.04947642,-0.013749066,0.09912185,-0.01739556,-0.009063958,-0.005810029,0.05281402,-0.052023064,-0.022935286,-0.04158633,-0.039883833,-0.02626457,0.060425553,0.0053975736,-0.0011739908,0.035842538,-0.02205645,0.06675809,0.02071046,-0.0442039,0.09952183,-0.017546328,-0.030088475,-0.023342926,-0.0009774046,0.012378683,0.009832682,0.062561244,0.11941688,-0.014027562,0.058041967,-0.11581091,6.744573e-33,0.04462325,0.02828698,0.00833063,-0.02280325,-0.07173576,-0.029833818,-0.07850193,0.054931954,-0.07603057,-0.07204632,-0.076277494,-0.0002697775,-0.009393572,0.00349529,-0.09050316,-0.047894835,-0.006608656,-0.0012407732,0.05927536,-0.02902576,0.057268422,-0.04240469,-0.06261359,-0.022766922,0.0024539637,0.01669186,-0.08683984,-0.016811766,0.07216583,-0.011154869,0.024955008,-0.16166396,-0.019982278,0.013576725,-0.008494084,-0.09253793,-0.093680255,-0.036981177,-0.018608935,0.0017230683,-0.026995447,0.0120114,0.024299622,0.033470664,0.031389296,-0.10497265,-0.06633316,0.08540723,0.023138706,0.008884684,0.035263374,-4.0681818e-05,0.09232878,0.019389195,-0.049796466,0.013128729,-0.01938912,-0.004557361,0.056893703,0.07460505,0.10688943,0.13678445,-0.016854223,0.018444909,0.06123236,0.04418361,-0.055570427,-0.0041798376,-0.034209594,0.05083312,-0.0114997,-0.02133149,0.07064898,0.10278394,0.058354057,-0.020807905,-0.009187403,0.03841409,-0.030881723,-0.02836934,-0.03803451,-0.047904033,0.005011901,-0.039348904,-0.075950906,0.0028181677,-0.0075413417,-0.10617,-0.0017564481,0.020818023,0.035370536,-0.059788465,-0.11428693,-0.011074911,-0.0019615265,-6.750816e-33,0.09768891,-0.08773008,0.049110122,-0.067823134,-0.021446934,0.08543,0.057508096,-0.03950939,0.0027522943,-0.011542375,0.07420166,-0.027856024,0.004474303,-0.014665101,0.020491224,0.03971385,-0.0035135413,0.03859843,0.028263234,-0.04022487,0.0026922917,0.08484609,-0.070875995,0.1147277,0.00716915,-0.055671856,0.06586551,0.006247082,-0.009855009,0.12743773,-0.039172977,0.0054374067,-0.061462246,0.006590343,-0.019502563,0.09628999,-0.063799754,-0.0021275736,0.0071095317,0.04586982,-0.020598143,-0.046941396,-0.008731301,0.029014474,0.02510644,0.07128453,-0.07172456,0.0068507465,0.0033902468,-0.033218984,0.0077295117,0.09273593,0.022343155,-0.005173233,0.01714497,0.08913688,0.056282934,-0.07091055,0.02109257,-0.08815929,0.039942544,-0.10320717,-0.030315598,-0.06797159,0.018387934,0.054026257,-0.016463999,0.035441283,0.0004925591,-0.032385617,0.022960922,-0.089502424,0.03420362,0.029344933,-0.010891012,-0.0068529495,0.0047986726,0.0053631547,0.029056368,-0.02693304,-0.012018137,0.019970104,0.017593177,-0.09019474,0.05775075,-0.022879647,0.08864755,0.06532836,-0.036145274,0.07464371,0.010891165,-0.028097434,-0.05278397,0.06456611,0.058837477,-5.3815643e-08,0.0719679,-0.08066351,0.1006384,-0.03184546,-0.009209433,-0.021886745,0.034252573,-0.0055190385,-0.017465854,-0.03886597,-0.06708001,0.088505745,0.029359825,0.015956718,0.08424426,-0.00092352746,-0.010492946,0.047052566,-0.0413592,-0.041165505,-0.033136692,-0.040527835,-0.09346625,-0.050245013,0.04389547,-0.08654132,0.03252311,0.04149564,-0.039784662,-0.055363767,0.025501415,-0.037937436,-0.033763245,-0.024548238,-0.0181308,0.084336564,-0.08946451,-0.0039025731,-0.0466496,0.0480445,-0.05106786,-0.087158516,0.0146685485,0.042881478,0.06591648,0.026081655,0.0070798923,0.02470004,0.02918633,0.059842337,0.03321602,0.020038992,0.034050338,-0.04720918,-0.097409606,0.013487689,-0.012134204,-0.04855499,-0.011261603,-0.013650451,-0.03386078,0.049006563,0.16899933,-0.0704925 +2.7.4.24,"This enzyme is activated by osmotic shock [4]. Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates [4]. The enzyme specifically phosphorylates the 1-position of the substrates [6].",384,0.99999994,-0.08730274,-0.06539476,0.001447162,-0.020323187,0.09740934,-0.03007755,0.07974607,0.10760546,0.020193,0.042167548,0.056313515,-0.002453261,0.007980259,0.07416803,-0.03529046,0.027762936,-0.006340372,-0.0094805,0.010263519,-0.022748403,0.08420503,0.014573216,-0.04260897,-0.0054773977,0.032025486,-0.02453596,0.104592144,0.07634332,-0.0055728424,-0.06917528,-0.074385874,-0.017058535,0.031340502,-0.05668037,0.03955868,0.115748785,-0.058918897,-0.0729011,-0.009907319,0.0061651263,0.10076969,-0.03734155,-0.030296568,-0.043372396,-0.026746908,-0.022374617,-0.006265633,0.08386236,0.021702347,0.024458114,-0.034851898,-0.034841526,0.016281473,0.034785762,-0.0844467,0.007261032,-0.07773989,0.029832335,-0.059027005,0.030662842,0.053711023,0.027861433,0.044541005,0.037417542,0.06773398,-0.02511882,0.04693921,0.0078056767,-0.047879796,-0.030258866,-0.0029215864,-0.022826448,0.037347063,0.0077367113,0.010398673,-0.031067055,-0.0045550475,-0.019491917,0.03747643,-0.017573597,0.057292044,-0.05492113,0.024094647,0.048645686,-0.0060538324,0.02010299,0.00992908,0.037226334,0.019785227,0.06780639,0.037678417,-0.015743325,-0.057862952,-0.054928593,-0.044353094,0.01892284,-0.0513386,0.016105065,-0.022493387,-0.005211975,-0.008052698,0.024529029,-0.07960317,-0.0095450375,-0.018047167,-0.032505352,-0.027460871,-0.032635182,0.030132325,0.033297636,-0.033807803,-0.017048499,0.05716207,0.008700629,-0.026908604,0.10644958,-0.06913384,-0.008078829,0.02893963,-0.03980057,0.0231315,-0.037003815,-0.03315092,0.08914559,-0.11033933,0.04081632,-0.053527307,3.1040714e-33,0.037928965,0.049872253,0.011225314,-0.043418285,-0.02530598,-0.0654292,-0.017472347,-0.04242995,-0.14060593,-0.0011422645,-0.06486755,-0.06617937,0.09600252,0.02308489,-0.013448765,-0.03518988,0.012627549,0.05000138,0.07246149,-0.000642836,0.029509157,0.045953017,-0.07400546,0.012110175,0.008108102,0.12258751,-0.10908928,-0.0028006588,0.027674694,-0.009003257,0.013717953,-0.043987527,-0.10048856,-0.03326695,0.052102923,-0.071046606,-0.08165973,-0.0497143,-0.005073832,-0.012103233,-0.00014591844,-0.057168614,0.011757325,-0.010052301,0.044681657,-0.0649084,-0.094341576,0.048611116,0.067139044,0.02245039,0.07865426,-0.026738381,0.11583212,-0.08609302,-0.053092543,0.0220497,-0.048820864,-0.00829409,0.06397776,0.04208131,-0.01058346,-0.0061476124,-0.053350784,0.034423072,0.030366072,0.043513253,-0.062341157,-0.07637559,0.019305456,0.124086775,-0.09359297,-0.0039131674,-0.013469641,-0.0035827174,-0.050656606,0.0113728745,-0.00996307,0.014925805,-0.08385894,0.033571213,0.024242098,-0.10833563,0.036438774,0.016258566,-0.057524797,-0.018009398,0.02694366,-0.025854269,0.004843933,0.018522043,0.106084704,-0.06069275,-0.052856073,0.04867378,-0.02682352,-5.163905e-33,0.123033896,-0.03904024,0.058088273,-0.113700934,-0.12740135,0.085426114,0.07431442,0.019252647,0.025134007,0.051809102,0.020266382,-0.009145088,-0.0749162,-0.00040299122,-0.012712305,0.041235276,-0.013834876,0.04837186,0.026339864,-0.013507995,-0.003578627,0.114527985,0.029991193,0.07740209,0.0006840822,-0.012108141,0.056868922,0.044719823,-0.02514293,0.08640536,-0.03288207,-0.03289596,-0.019714868,0.009714436,-0.049007915,0.01653451,-0.078033864,-0.063678205,0.002107559,0.0122790625,-0.012494135,0.09015408,0.012311984,0.08807155,-0.026252866,0.055170707,-0.037787024,0.037750226,-0.07287071,-0.044631183,-0.028078541,0.07528735,0.0014971803,0.0212707,0.07890352,0.00067554985,-0.0040941196,-0.054791026,-0.06703481,-0.045000974,-0.04382934,-0.058401883,0.007283643,-0.0364027,0.050287805,0.049785223,-0.03382439,0.0059785047,-0.027185068,-0.05671659,0.04837734,0.06705711,-0.008670865,-0.044090007,-0.054246955,-0.021765316,-0.042601705,0.02423264,-0.0016073606,-0.022948446,-0.008858098,0.010543357,-0.09177705,-0.05513428,-0.013320209,-0.041190125,0.049498893,0.16360223,0.11220415,0.010579482,-0.020003157,0.034993563,0.013689909,0.015637068,0.054083996,-4.3058364e-08,0.04928292,-0.036790613,0.0638401,-0.042048953,-0.014362973,0.057782013,0.059732847,-0.030374458,0.006300153,-0.013293231,-0.03622764,0.052245203,0.08560912,-0.014577038,0.08588627,0.0056481916,-0.03279838,0.07033802,-0.018522188,-0.05100411,0.0030030508,-0.04994882,-0.04498962,0.03422601,0.07651383,-0.015549489,0.06638195,0.025061013,-0.019776685,-0.028317338,-0.07542654,-0.03332148,-0.015946528,-0.020403825,-0.04329263,0.15250954,-0.04890634,-0.0020094817,-0.059158213,-0.0074563245,-0.078998856,-0.036551166,-0.039581988,-0.023760865,-0.045878317,0.040229373,0.034900874,0.00042971602,0.019880103,-0.013300786,-0.073991224,-0.03857065,-0.030496016,-0.020705769,-0.040148906,0.0047385134,-0.06531919,-0.05609709,-0.01853068,-0.015191024,0.043787155,0.041652557,0.11409683,-0.0852605 +2.8.2.36,"The enzyme from the bacterium Streptomyces toyocaensis catalyses the final step in the biosynthesis of the glycopeptide antibiotic A47934, a naturally occuring antibiotic of the vancomycin group. ",384,1.0,-0.024724834,-0.008452883,-0.1406777,-0.03562407,-0.015539296,0.032661878,-0.07454417,0.062051643,0.0041981004,-0.027003285,0.022954777,0.0359811,-0.0032396128,-0.004987769,-0.04267726,-0.050442416,-0.05243057,-0.006169493,0.03135736,-0.070579186,0.038012378,0.08019377,0.047881614,-0.044038463,0.0563154,0.015025791,0.0010242395,-0.027240552,0.020268803,-0.06926741,0.07550549,-0.0380726,0.061665736,-0.04661622,0.08526953,0.031818286,-0.100451015,-0.05042399,0.15516002,-0.011207174,-0.0043070363,0.003722812,-0.0065030735,0.0076053324,-0.049642257,0.07597066,0.04693308,0.016399508,0.035138883,0.03576597,-0.025565818,-0.03405362,-0.058756806,0.019951932,0.042602077,0.057424445,-0.06705298,-0.0038435287,0.017036092,-0.038554277,0.07182778,0.005378021,0.058508128,-0.009563611,-0.09578351,-0.056392275,0.06320641,-0.083762266,0.051389147,0.018458944,-0.05760249,-0.016239539,0.02559724,0.020902334,0.015420206,0.034031276,-0.052366324,-0.0018226308,-0.0104592955,-0.024406198,0.077903725,0.007432845,0.022461366,0.12105682,0.0045734113,-0.022051688,0.06543418,-0.001368721,0.089916445,0.039560992,0.041232076,-0.05067109,-0.03640174,-0.048693508,-0.049418356,-0.03236282,-0.024433816,-0.038669847,-0.011453398,-0.014633728,-0.04417519,0.02865936,0.03774056,-0.016535003,0.0026843662,0.02575027,-0.028835038,0.056444924,0.02962667,-0.03000232,-0.024385553,0.06478792,0.0009270209,-0.043038297,-0.048825618,0.0067691854,0.12329765,-0.03744931,-0.07231363,-0.027660556,0.067659296,0.006351201,0.012584142,0.045964602,-0.0449472,0.03421037,-0.08813052,2.19475e-33,-0.021214087,0.071986936,0.035767157,-0.062326077,0.040150713,-0.030513423,-0.07765242,-0.007313356,-0.008440262,-0.007936673,-0.11876471,-0.10354641,0.013921652,0.09979886,0.013338572,-0.010157878,-0.0060654925,0.029437475,0.0110119255,-0.046940405,0.011319641,-0.0017488807,-0.0065788156,-0.028442392,0.0457104,0.09862233,0.021466954,0.051019143,0.103809774,-0.03308415,-6.670301e-05,-0.06897919,-0.05537575,-0.0054241647,0.10772589,-0.06884439,-0.071151055,-0.10496996,0.1383343,0.04906473,0.004432004,0.054404948,-0.018897703,-0.049561303,0.03519804,0.021805808,-0.013374421,0.06362447,0.072433576,0.049306717,0.06301118,-0.057881232,0.03871101,-0.01645482,-0.07100066,0.03236321,-0.007580751,0.054946505,-0.0037869136,0.04136626,0.013325593,0.021519035,0.04529626,-0.021786397,0.06145534,0.03543788,-0.043986574,-0.015153472,-0.005986184,-0.021099126,-0.059892785,-0.024993867,0.026854845,-0.0114458725,-0.01130001,-0.0041174903,-0.017785398,-0.0036282938,0.054033518,-0.027569748,-0.07184898,0.06486311,-0.03888325,-0.057522118,-0.017245563,0.044166192,-0.075818755,-0.0848515,0.008325778,0.08598089,-0.023263304,-0.058632746,-0.066450395,0.02294292,-0.03947193,-4.113397e-33,0.059936102,-0.07689137,0.034316253,-0.013482721,-0.03968463,0.030672045,-0.06929392,-0.04362326,-0.03026498,0.007911291,0.00045254815,-0.001283063,0.050480396,-0.07196095,0.015205216,-0.040602595,0.04369879,0.13385636,-0.040251818,0.008398074,0.051261205,0.036741763,0.00049220823,-0.042208113,0.004902515,0.031496555,0.0586976,0.052178692,0.05395492,0.041183393,0.009199008,-0.02437712,-0.052092504,-0.040584166,-0.03206379,0.08084059,-0.009027682,0.017325372,0.059627015,-0.07915937,0.10122715,0.041516233,0.005402859,0.04303827,0.04000273,-0.013842123,-0.039934587,0.06852311,0.03810853,-0.07922029,-0.0006130997,0.038205497,0.019740624,-0.012570071,0.0071060527,0.058015425,0.043050274,-0.054507583,0.037634302,-0.05027507,-0.042668846,-0.044405516,0.052527536,-0.0050488347,0.03700318,0.036135282,-0.01900642,0.055230938,0.108472176,-0.058564708,0.07286152,0.009586443,-0.045118205,0.022681285,-0.01253308,0.035996087,-0.033516746,-0.063006155,0.024672212,0.0034429259,0.028361563,-0.017306821,0.026910126,-0.0027573707,-0.031955786,-0.06919988,0.033443008,0.08988349,0.00467874,0.044720102,-0.010212965,-0.020616012,-0.006567196,0.06109185,0.032139085,-3.122999e-08,0.07373545,-0.020004869,0.062612124,-0.052812334,-8.886579e-05,0.007484064,-0.07060625,-0.009143499,-0.038163535,-0.061706163,-0.009734674,0.0076971324,-0.01459284,-0.07169492,-0.04039687,0.07921392,-0.12310618,0.015655344,-0.046066895,0.035350196,-0.107393116,-0.014268558,-0.08626109,0.048140135,0.033033293,-0.05977302,0.015121591,0.019997098,-0.05237068,-0.0059256833,0.04133591,0.056869075,-0.06020241,-0.01770166,-0.060997114,-0.09362574,-0.07430498,-0.007291194,0.07347095,-0.042164106,0.022542333,0.03689332,-0.033673868,0.055417515,-0.1158868,0.05728827,-0.04011747,-0.0646623,-0.107540876,0.0066840886,0.067641206,0.021193342,-0.015835518,0.012199615,-0.14103504,-0.00064635696,-0.038384464,-0.06931015,-0.064802326,-0.052684747,-0.07291439,0.005799674,0.16180953,0.0017845596 +3.2.1.163,"The enzyme is specific for (1->6)-linked mannobiose and has no activity towards any other linkages, or towards p-nitrophenyl-alpha-D-mannopyranoside or baker's yeast mannan. It is strongly inhibited by Mn2+ but does not require Ca2+ or any other metal cofactor for activity.",384,1.0,0.04981663,-0.056867663,-0.05008817,-0.06540019,0.026277369,0.06784567,-0.033387095,-0.01045286,-0.052144524,0.08034303,0.047549766,-0.050432477,-0.06096989,0.04004986,-0.031075075,0.03844573,-0.039801713,0.024908125,0.04587046,0.02874898,0.06644304,-0.0075578783,0.037650798,-0.039146844,-0.00201775,0.006258108,0.0013178823,-0.046784073,0.0044788485,-0.10295249,-0.06835413,0.025564142,-0.005408929,-0.0333497,0.078663535,0.06106712,0.044006392,0.0053845476,-0.00022294905,-0.05629507,0.057250008,-0.03219056,0.05768265,-0.026078044,-0.019358385,-0.024741624,-0.014856186,-0.043957356,0.003247817,0.05611123,-0.073002174,-0.031869244,0.07418625,0.040618837,-0.010587319,0.044777576,-0.059256695,0.017226355,0.02966083,-0.031732507,0.031684678,-0.038519785,0.10140613,-0.015458956,0.06863628,-0.012344081,-0.08752625,-0.051261295,0.018795682,0.0044850004,0.002181672,-0.097533755,-0.032500166,-0.022977252,0.0030089065,0.012449396,0.04445749,-0.09053368,0.082555324,-0.05427712,-0.011629886,0.0493893,0.12528664,0.020385334,-0.013762408,0.06794533,0.027339423,0.03807591,0.062099706,0.012092388,0.06443017,0.045310974,0.057372384,-0.040927522,-0.004648377,-0.025478711,-0.06369662,0.060727883,-0.030583993,0.007066991,0.0947496,0.065835916,-0.07680628,-0.07502931,-0.017351959,0.027769797,0.017758355,-0.0077094133,-0.0008672491,0.025792357,0.05191258,0.057344448,-0.024388822,-0.027882705,-0.061780293,0.04841532,0.09909078,-0.053243846,-0.017927008,-0.043334633,0.023087718,-0.01626815,0.0148565825,-0.010762488,-0.08511631,0.025787678,-0.10940018,1.7279554e-33,0.044461306,-0.026894292,0.067583956,-0.057292588,0.09117895,0.009408047,-0.046456877,-0.046295043,-0.039007176,-0.06502601,-0.106958024,-0.034970153,-0.018813964,0.06419988,-0.012851723,0.041686848,-0.016690547,-0.01593129,0.054900464,-0.02550877,0.04123796,0.06456799,-0.061500557,0.046045203,0.06738625,0.07818766,0.016557464,0.017536618,0.030467896,-0.023256548,0.0069279387,-0.07476828,-0.069788545,0.0077948896,0.055609625,-0.016188214,-0.031310212,0.013811594,-0.024701057,0.021422023,-0.032600936,0.03635121,-0.018502286,-0.04133177,0.020940708,-0.10839069,-0.008254512,0.04039711,-0.023138903,0.035912413,0.044886768,-0.023348758,-0.02898175,0.039567716,-0.010911089,0.03120413,-0.05762201,0.02860979,0.060447745,0.043348346,0.018605502,-0.05567309,0.027188739,0.02378427,-0.024392715,0.049198393,-0.028919784,-0.05075183,0.009391186,0.015483598,-0.07915787,-0.038066607,0.06393038,0.029488912,0.028291464,-0.08350146,-0.04373848,-0.026816705,0.047299884,0.049212225,0.05156944,-0.045788743,0.020755125,-0.024849584,-0.07562448,-0.03042832,-0.09781578,-0.105155244,-0.03946074,-0.0244258,0.05979889,0.020867888,-0.1284223,0.058939945,-0.04474044,-4.2719132e-33,0.074484296,-0.06824168,0.13132943,-0.08284649,-0.09848152,0.03950572,0.0863772,-0.12226415,0.05498737,-0.053101607,0.105278365,-0.024358688,0.03327852,-0.030766496,0.029830158,0.042934608,0.020631647,0.09684307,-0.012078877,-0.0069598444,-0.006403767,0.101678185,-0.024185946,0.023682646,0.036920447,-0.013584718,-0.02821451,0.061689958,0.03357091,0.018031968,-0.028452914,0.037903056,-0.028581588,-0.10251608,-0.025064023,-0.025557034,-0.06971272,0.026652481,-0.029118074,0.02384559,-0.040009905,-0.0047364756,-0.018901287,0.057556577,-0.026039401,0.008925212,-0.10355526,0.023393828,-0.06310922,0.032329593,0.0049942425,-0.036854494,-0.013171572,-0.030019302,0.07126646,0.046485938,-0.038347885,0.03326527,-0.042193368,0.04933809,0.0012001382,-0.033346515,0.020391965,-0.0049573826,0.062275972,0.12946205,-0.058501437,0.031046137,0.070132226,-0.017659051,0.07687407,0.073489994,0.057117607,0.053138297,-0.044825863,-0.00086253014,-0.050718635,-0.054173168,0.04079601,-0.07164425,-0.047967043,0.044716794,0.0012040982,-0.018346757,0.0022729554,-0.002096134,0.064425215,0.067998566,-0.031861365,0.07704761,-0.04408091,-0.038477708,-0.07642636,0.07140276,-0.03478961,-3.8318362e-08,0.039338887,-0.071267545,0.043078076,-0.11118981,-0.041461363,0.05516543,-0.0015176316,-0.0436486,0.030713426,0.029240344,-0.00825977,0.07103809,-0.004270625,0.01460721,0.0065134284,-0.035339314,0.029196605,0.019152742,-0.079417706,-0.03880257,-0.087829374,0.047987066,-0.10139551,0.052154526,-0.012361128,0.010849958,0.042820897,0.05719731,-0.016542098,-0.044356372,-0.0124447895,0.024454324,0.006021511,-0.06250269,-0.0521652,0.09810194,-0.03534575,-0.068465814,-0.06280038,-0.027260728,-0.024607271,-0.01874872,0.05789253,-0.003843714,-0.045070104,-0.0030056708,-0.050839677,0.0072972635,-0.013280812,0.031212024,0.030253634,0.035766188,-0.066366635,-0.07330432,-0.10997695,0.057675384,0.010819369,-0.047202315,-0.018610291,-0.040876392,0.058982804,-0.13421087,0.104838446,-0.059939962 +1.14.13.102,"This microsomal cytochrome P-450-dependent enzyme is specific for (+)-marmesin, and to a much lesser extent 5-hydroxymarmesin, as substrate. Furanocoumarins protect plants from fungal invasion and herbivore attack. (+)-Columbianetin, the angular furanocoumarin analogue of the linear furanocoumarin (+)-marmesin, is not a substrate for the enzyme but it is a competitive inhibitor.",384,1.0,-0.063063055,-0.016367983,-0.06665853,0.03167913,0.16347145,0.089901574,-0.12339406,0.07211865,0.035832483,0.008036233,0.04631162,0.027268326,-0.12534761,0.006405535,-0.047061067,0.033830766,-0.07549351,0.057507668,-0.002653708,0.063540965,0.0010225659,0.0044058263,-0.018165125,0.07667007,-0.0033117,-0.075359,-0.020251691,0.07883211,0.026387433,0.042997688,-0.0026599364,0.0427877,0.054293986,0.02010922,-0.06337097,-0.025212675,-0.028238965,-0.08798795,0.05584331,-0.08139694,0.04443526,-0.023724606,0.018248,-0.03650824,-0.07861925,-0.12703049,-0.055246197,0.04643518,0.059120577,-0.027131768,-0.06742879,-0.05452701,-0.12716357,0.025735656,-0.02426715,-0.04163306,-0.042577147,-0.06884261,0.03636601,0.041019905,0.028191546,0.016591016,-0.059130087,0.012123065,-0.016080702,-0.025784323,-0.07532751,0.02545432,0.049963366,0.06880958,-0.0034272922,-0.105402656,0.010356184,0.009052384,-0.0060553574,0.10486879,-0.10622737,-0.005481857,-0.0025068454,-0.052431714,0.005400995,0.0410812,0.04764403,0.081864886,0.04822263,-0.0043907436,-0.0066291387,0.025457483,0.04608777,-0.005857576,0.086590886,0.016969714,-0.024489857,-0.020372273,-0.09406553,0.042353265,0.05837598,-0.004415091,-0.070203945,-0.00046564863,0.046783242,-0.015472887,0.005886129,-0.1376939,-0.025245529,0.085246496,-0.04693269,-0.028152784,0.061913818,-0.057901952,-0.038822494,0.026808783,-0.08554613,0.00018438489,-0.019172005,0.014063576,-0.03387963,-0.09549432,0.04895457,0.02947893,-0.016957512,-0.0010108394,0.056010757,0.042532846,0.023329416,-0.015066391,-0.04994666,1.320068e-33,0.036204357,-0.045191318,-0.02801648,-0.0026287711,0.0014807698,-0.045563456,-0.039354745,-0.0259468,-0.035809312,-0.03056439,-0.08148666,-0.021003174,-0.0073314216,0.018991726,-0.028778277,-0.023684068,-0.020226695,-0.06923474,0.0830993,0.07232636,-0.007882114,-0.026429847,-0.037741333,0.007929307,0.010732204,0.10712802,-0.04248709,0.063213766,-0.013949511,0.032648623,0.03318335,-0.019387709,-0.09164486,0.026767718,0.07883983,0.07922591,-0.030717235,-0.051310986,-0.07422291,0.08889214,-0.021103753,-0.024720142,0.0068212915,-0.03922768,0.077450484,-0.008091277,-0.11486955,0.06671495,-0.0028379697,0.010836888,0.00078284135,-0.020811945,0.06090663,0.05952955,-0.0151365865,-0.0014693593,0.03366398,0.01945191,-0.0066739502,0.01975037,0.0010587762,-0.056588158,0.03173636,0.06400911,0.034553647,0.04124655,-0.023808405,-0.03674293,-0.004054733,0.062355675,0.017971713,0.03544431,0.026682258,0.054188155,0.0632827,-0.02267744,0.063839935,0.10846987,-0.00056749483,0.0993457,-0.015537624,-0.032545652,-0.029836936,-0.0027181252,-0.12238676,0.026329009,-0.0051750406,-0.0029361474,-0.01649844,0.01651029,0.03697568,-0.06737892,-0.005698964,0.07048433,-0.019813789,-1.9753861e-33,0.01501961,-0.07747689,0.08635701,-0.055042583,-0.122993395,0.115197726,0.0077947374,-0.047098808,-0.046076186,-0.019692274,0.10954348,-0.0134797795,0.016450176,0.015564861,0.013499023,0.037156384,0.005729106,-0.036743235,0.0128981145,0.028087905,-0.043731835,0.050972294,0.018376378,0.07312822,0.044665508,-0.013991228,0.004424513,0.018245645,-0.008301348,-0.0050928085,0.0030926482,0.024255425,-0.038294386,-0.042501137,-0.030196318,0.020873941,-0.023514878,0.022323651,-0.01990242,0.027444446,0.06387148,0.03875051,0.015116565,0.08742621,0.01522171,0.011885377,-0.04014769,-0.025934748,-0.03910032,0.008701703,0.04321826,0.053047057,0.020308819,0.023860421,0.056291882,0.00297854,0.090469725,-0.02918934,-0.007845055,-0.015755259,-0.07481163,-0.0076765753,-0.0596824,0.0118487775,0.07179525,0.093139686,-0.047978505,0.054529227,0.01366248,0.008798991,0.10368599,0.0056553683,0.064744115,0.06394373,-0.077920824,0.011695843,0.062537715,-0.0330263,-0.055610783,-0.0070668594,0.022397442,-0.07434487,-0.046687875,-0.054942183,-0.0696918,-0.02946485,-0.019933961,0.07554225,0.044193074,0.023064965,-0.01615631,0.06759997,-0.08287706,-0.0263048,0.08762905,-3.4445222e-08,-0.0029712578,-0.07813284,-0.022433724,-0.04305932,0.0060749683,0.0100060385,-0.011048153,-0.02355949,-0.024106039,0.06776144,-0.028660083,0.10025335,0.007001467,0.00032750162,-0.0531476,-0.03487728,0.06292427,0.013408974,0.008540026,0.007221569,-0.091850735,0.035274647,-0.04612053,-0.066023424,-0.014186386,-0.105735496,0.0052628284,0.050905257,0.04422995,0.017594827,0.0065288516,0.026879627,-0.069100976,0.028860146,-0.03005233,0.07441152,-0.0015566451,-0.10200441,-8.308441e-05,0.027232483,-0.03497402,-0.0011880893,-0.03805554,-0.063255705,-0.02045035,-0.0145110665,0.07885389,0.03648064,0.026901057,0.02721622,-0.015271353,0.0107617695,0.029425468,-0.0839304,-0.08950128,-0.019196933,0.09903392,-0.010620065,-0.04190502,-0.030244792,-0.066696666,-0.068054095,0.116147935,0.03597176 +2.6.1.84,"A pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.",384,0.99999994,-0.05694987,-0.11255952,-0.09337437,-0.017599525,0.064345874,0.06845319,-0.04717049,0.06394699,-0.0044194744,0.01867682,0.007605512,0.04755821,-0.03357996,0.104723155,-0.038785867,0.08807899,-0.11770719,-0.06056473,0.06329883,-0.01736499,0.13693556,0.10119238,-0.07467743,-0.06854233,0.060107306,-0.015438808,0.013220396,-0.019310756,0.01890779,-0.009807626,-0.059378102,-0.09881943,0.044154786,-0.10783269,0.08482845,0.093095325,-0.09762408,-0.00064091984,0.11893611,-0.018458549,0.020641785,-0.034946702,-0.08174406,-0.08807895,-0.022566758,0.0152066555,0.08141254,0.0026140106,0.01634753,-0.0016026243,-0.04482354,0.005934349,-0.017306535,0.0129078515,-0.029970782,0.040133867,-0.038498916,-0.011458417,-0.025546039,-0.040115405,-0.06299308,-0.008708636,-0.022200007,-0.023131754,-0.017321378,-0.05736501,0.08329176,-0.017681213,0.08005975,0.009869801,-0.07499602,-0.028392041,0.034443468,0.050486818,-0.009579143,-0.032306056,0.0209072,-0.016658114,-0.023056226,-0.02428652,0.045628186,-0.043119956,0.021950731,0.06159911,0.022863403,-0.08421571,-0.034136087,0.03889432,0.049475323,-0.008063894,0.06608656,-0.013369816,-0.021706123,-0.019071393,0.025129793,-0.012238306,0.010052768,-0.01367076,-0.026899505,-0.040884066,-0.013596028,0.027933823,-0.03356279,-0.045318738,0.020839512,0.018914253,0.03674316,0.06639154,0.017946169,-0.018466836,0.023426957,0.030252136,0.016697843,-0.016252745,-0.026877737,0.055886827,0.0635376,-0.05776682,-0.09739976,0.061976463,-0.015456012,0.01967578,0.12220482,0.0672834,-0.059243016,0.03765614,-0.070820026,4.723378e-33,0.021926349,0.030556593,-0.028255522,-0.039191794,-0.0063211657,0.01720104,-0.09201874,0.030053716,0.06103789,-0.037220765,-0.06366736,-0.072975524,0.062088877,0.031065175,-0.047437347,-0.01101051,-0.041328654,0.011537952,0.05151769,-0.02005976,-0.010714244,0.04464005,0.017281288,0.049744386,0.019862777,0.021369739,0.107069984,0.025677228,-0.06784888,0.002457764,0.022113277,-0.086709276,-0.080589816,-0.021615654,0.03986909,-0.0046477695,0.004708936,-0.047457974,0.055508275,0.074006274,-0.037750013,0.016745036,-0.0006509268,-0.022725312,0.03664346,-0.049771078,-0.050995946,0.118687406,-0.09454848,0.09217847,0.06414626,-0.077985525,0.04003604,-0.018180305,-0.077456094,-0.040632296,-0.035710018,-0.01577506,0.090556785,0.061646298,0.09693965,-0.021765148,0.013099818,0.061528563,-0.040270053,-0.0075389505,-0.03244996,-0.06960063,-0.01851999,0.09032676,-0.07911454,-0.03509976,0.070550844,0.033563536,-0.0049158204,-0.089746356,-0.07939661,0.09870245,0.014986148,0.0031249868,0.0062383893,-0.027608879,0.005440645,-0.007828231,-0.022774542,-0.06198373,0.050945576,-0.06072151,0.009369549,-0.026633317,-0.0044967397,-0.044723187,-0.02567439,0.06228567,0.037259497,-4.493604e-33,0.1315544,-0.09538474,0.06735224,-0.072198436,-0.055244643,0.03051845,0.0760742,0.030120112,0.0342101,-0.013970007,0.030842328,0.035810664,0.0053709857,-0.011408859,0.057819206,-0.021264862,0.009345958,-0.009887173,0.021802155,-0.022071991,0.014952369,0.05392879,-0.070827655,0.034461774,0.04513083,0.02950665,-0.08585694,0.029772261,0.0007317579,0.0709901,-0.022111062,-0.0034391705,-0.019411746,-0.037297145,-0.037801757,0.08393229,0.0016059302,0.01887016,-0.051390134,-0.022210427,0.10371338,0.057878025,0.031440306,0.05354462,-0.024942365,-0.0031394179,-0.028726054,-0.08940299,-0.057331547,-0.12960956,0.04948554,-0.033151932,0.04721468,-0.014803789,0.021301178,-0.009899721,-0.012972276,-0.016168443,-0.053774,0.007951389,0.012747592,-0.089271456,-0.0015596711,-0.0060008094,0.06378406,0.0321722,0.041428104,0.04106421,-0.029449023,0.023279665,0.043023568,-0.010123896,0.04699821,0.07909676,-0.048525147,0.057016563,-0.038956065,-0.060408175,0.020902323,-0.06220267,-0.004497666,-0.068129435,-0.035968985,-0.05300071,-0.033173103,-0.02029277,0.016865,0.10563877,0.032685827,-0.032759845,-0.035996474,-0.045711532,0.02552484,0.032793712,0.08965139,-4.487813e-08,0.03171003,-0.01432751,0.02996819,0.05339235,-0.03917535,0.059372194,-0.01003529,0.01939112,0.010177591,-0.052122522,6.241844e-05,0.059773188,-0.0073224385,0.009558549,0.033158667,0.062334225,-0.10147469,0.060076814,0.004447512,0.0013416518,-0.10640189,0.0058541205,-0.14108142,-0.011335732,0.050897464,-0.033461794,0.049268913,0.043781262,0.0023782318,-0.08543623,-0.004163362,-0.009076227,-0.010733197,0.010924218,-0.074384674,0.021358384,-0.005772354,-0.06546105,0.0032462098,-0.0056080986,-0.015558059,0.0123388525,-0.036238402,-0.018738361,0.015078768,0.057149,0.0043518324,-0.010676669,-0.0305683,-0.027609,0.0809545,-0.0502165,0.028516209,-0.046423145,-0.094231255,0.04243952,-0.07582255,-0.036451,0.031638794,-0.0308132,0.040291727,0.034285516,0.12857307,-0.021873321 +3.4.22.65,"This enzyme, derived from the house dust mite, is a major component of the allergic immune response [2]. The substrate specificity of this enzyme is not altogether clear. It cleaves the low-affinity IgE receptor CD23 at Glu298!Ser299 and Ser155!Ser156 [1]. It also cleaves the pulmonary structural proteins occludin and claudin at Leu!Leu, Asp!Leu and at Gly!Thr bonds [1,2]. It can also cleave the alpha subunit of the interleukin-2 (IL-2) receptor (CD25) [4]. Using a positional scanning combinatorial library, it was found that the major substrate-specificity determinant is for Ala in the P2 position [3]. The enzyme shows only a slight preference for basic amino acids in the P1 and P3 positions and a preference for aliphatic amino acids such as Ile, Pro, Val, Leu and norleucine in the P4 position [3]. Belongs in peptidase family C1A.",384,1.0,-0.05020534,-0.05727969,-0.0027766929,-0.11811178,0.091967255,0.016165823,0.023515228,0.06176472,0.012227296,0.025572453,0.033005666,-0.01702885,0.022991337,0.057509117,0.011329984,0.069960184,0.0056056352,0.033315517,-0.025014782,-0.04618269,0.044841513,0.071388125,0.02261022,-0.053311024,-0.025410805,0.015387818,0.049092676,-0.035429616,0.010919011,-0.08128045,0.05239977,-0.006288737,0.022542072,0.020371107,0.014457049,-0.059400372,-0.09172657,-0.004646902,0.008042332,-0.013872691,0.07514468,0.049745727,-0.041551806,-0.08464463,-0.04498002,-0.08333878,-0.025227193,0.027676482,0.07056154,0.13877843,-0.039609667,-0.024200516,-0.030124936,0.04184693,0.0092612505,0.0014181563,-0.13880569,0.016269948,0.04552127,-0.006814565,-0.026566962,-0.03478426,0.01568467,0.017099202,0.019010771,-0.030494452,0.015786644,-0.033936795,0.00056471996,-0.07209583,-0.03786595,-0.05673471,-0.046359103,0.080273636,0.09050204,0.054385204,0.0065272306,-0.03460126,0.0015265413,-0.04052854,-0.013749533,0.06146463,0.11586391,0.11878046,0.028489359,-0.020760901,-0.008404037,0.06694098,0.031165654,-0.015891137,0.107271954,-0.081910804,-0.049675986,0.041663162,0.054255202,0.051994205,0.033803243,0.038139105,-0.024388915,0.034684323,-0.060291555,0.013986222,-0.017120838,-0.068087414,-0.064561985,0.012537627,-0.013172786,-0.050182566,0.018172933,-0.0034721664,-0.0014377958,-0.019894956,0.011081737,-0.04296698,0.042188182,0.04962002,0.022061948,-0.02321129,0.055113263,-0.04112571,0.042923618,-0.07089819,0.002562101,0.06258741,0.01642487,0.0759341,-0.08675413,4.7321395e-33,-0.0074042226,0.041328724,0.077162005,0.020199707,-0.008379036,-0.081692286,-0.018089235,0.0048264833,-0.047571205,0.021866739,-0.09389285,-0.07424331,-0.01775553,0.04160848,0.030993963,-0.012658909,-0.01294262,-0.048724428,0.0381733,-0.029825792,-0.007958697,0.049449384,-0.023051715,-0.03473239,0.00045513958,0.047601603,0.039675888,0.06205443,0.050739948,0.0077298833,0.0384266,-0.011244681,-0.08824473,0.028732607,-0.004098295,-0.012078288,-0.05851685,0.019707074,-0.00823002,0.04225111,-0.020208728,0.0005431008,-0.026667302,-0.04505312,0.09125068,-0.116529815,-0.041793197,0.0075548766,-0.0013816768,0.07075987,0.07882751,-0.043103036,0.09381124,0.060617913,-0.02868986,0.021845577,-0.025514865,-0.04043838,0.009767269,0.028913617,0.036143467,-0.019610282,0.027901521,0.037917968,-0.013637028,0.049672306,-0.046869423,-0.085613154,0.0068464153,0.07290287,0.041504916,-0.028216861,0.04512684,-0.009595334,0.048193354,-0.039504338,-0.032573316,0.098532096,0.024402939,0.0032409395,0.05268017,0.040978834,0.0142020965,0.078729965,-0.09933674,-0.14809234,-0.032492675,-0.03867493,-0.033493284,-0.0055035497,0.09835096,-0.028981986,-0.07598423,0.08747087,-0.06181785,-5.6279826e-33,0.08379665,-0.09110809,0.12985712,-0.11248248,-0.1443609,0.05824325,0.106142685,-0.02590433,0.06027433,0.019012801,0.08185949,-0.0051144147,0.0124836,-0.000239387,0.030288486,0.063842885,-0.046763066,0.048916407,-0.062616676,-0.003175987,0.002227793,0.019638104,0.03515308,0.047890782,0.0026442374,0.012423965,0.08399045,0.019457981,0.045590274,0.0024185358,-0.07667897,0.040289506,-0.030623684,-0.025416952,0.019161562,-0.04652535,-0.031033054,0.0018033838,-0.07690132,-0.044663277,-0.06902426,0.041985057,0.047938626,0.0402431,0.05591396,0.057483707,0.07726895,-0.037162416,-0.045987763,-0.07526142,0.002513007,0.030723756,0.05319524,0.014543624,0.016045786,0.090253554,0.011703066,-0.06658222,0.018510027,-0.03995018,0.022371892,-0.0066768425,-0.00887008,-0.0053261593,0.0011233458,0.042340416,-0.078503616,-0.04937855,-0.02784037,-0.014244855,-0.048854653,-0.12736921,0.013756328,-0.017478833,-0.012610927,-3.770501e-05,-0.015797757,0.00020225461,0.0066823238,-0.020839559,-0.09504687,-0.022733612,-0.076495625,-0.0812887,-0.013895188,-0.02599847,0.0090649845,0.051978093,0.03792155,0.06342778,-0.06822513,0.03699814,-0.03832057,0.05330729,0.019168954,-5.8087995e-08,0.04713483,-0.09340567,0.0385365,-0.04773234,-0.091837496,0.03166716,-0.021157676,0.007675665,-0.032814965,0.048715282,-0.0024098959,0.047546934,-0.023387387,0.019244343,0.019457797,0.061339837,-0.030176051,-0.032760724,-0.01801546,-0.075101495,0.018072246,0.023041984,-0.036162578,0.026689192,0.009938155,-0.08940014,-0.046666343,0.07006448,0.015094282,-0.0336532,-0.07719439,0.030563768,-0.036846526,-0.11256502,-0.033460926,0.026557805,0.00822106,-0.07479688,0.03889097,-0.018271515,0.04910792,-0.06880604,0.0013452375,-0.055747673,0.08813456,0.0154000195,0.064972155,0.017210959,0.005614187,-0.07028112,-0.04628105,-0.019411273,-0.014499048,-0.043159567,-0.09027229,0.011121848,-0.083164945,-0.10767056,0.10516987,-0.049887374,-0.020582471,-0.02231892,0.019102456,0.0110401595 +2.3.1.182,"One of the enzymes involved in a novel pyruvate pathway for isoleucine biosynthesis that is found in some, mainly archaeal, bacteria [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2]. 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In the absence of PabA and glutamine (but in the presence of Mg2+), PabB can convert ammonia and chorismate into 4-amino-4-deoxychorismate. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate. cf. EC 2.6.1.123, 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming).",384,1.0,-0.03583183,-0.07812981,-0.054082364,-0.082556754,-0.015291115,0.06385433,-0.010103554,0.016647222,-0.011921317,-0.0039829635,0.047158156,-0.08395504,-0.024855236,-0.020130368,-0.020600837,0.043974172,-0.068100676,0.025328547,-0.029107628,-0.06330437,0.049171425,0.080819845,-0.08748012,-0.035353266,0.010708146,0.033614635,0.0163449,-0.073981464,-0.008393852,-0.08331839,0.054646287,-0.07163287,0.026229192,0.0014528884,0.055633027,0.07601114,-0.06650558,-0.04888677,0.102338366,-0.06988319,0.020280734,0.08433352,0.006738664,-0.042881906,-0.037743088,0.027747454,0.056741606,-0.026015406,0.025232218,-0.11560252,-0.020117093,-0.055849668,-0.038855083,0.028037827,0.050709583,0.03837767,-0.08007032,0.01034105,-0.037788082,0.02540991,-0.06810605,0.053312723,0.016527047,-0.063821904,0.06908523,0.015854605,0.03634699,-0.0784941,0.039534274,-0.08851314,-0.061301816,-0.048375968,0.007281544,-0.0017812055,-0.06319436,0.014063433,-0.042568915,0.07382636,0.04835502,0.0028778566,0.01412739,-0.039489705,0.05035928,0.038688958,0.022258732,-0.031737756,-0.027942171,0.050931476,0.07887499,-0.03999147,0.045999877,0.03320992,0.018444408,0.019010888,-0.017465865,0.027719377,0.021427782,0.04097488,0.08811641,-0.038818434,0.048831638,0.07113142,-0.022275994,-0.11653233,0.0026198071,-0.006362043,0.07150024,0.0605441,0.020504568,0.021454506,-0.043463353,0.061383598,0.045749307,-0.007116358,-0.074114546,0.03728407,0.04734545,-0.02132159,-0.02425156,0.028850993,-0.011403156,0.051984284,0.072647266,0.061380006,-0.034757733,0.06488997,-0.118269734,2.7616947e-33,0.05116624,0.02436312,0.050968405,-0.021916274,0.01740688,0.020516926,-0.048945684,-0.015249973,0.018845355,-0.072446615,-0.13219807,-0.071712814,-0.0007879144,0.035604782,0.020476319,0.016056016,-0.114595756,-0.028256971,0.07998557,0.051304583,-0.048877005,0.06837434,-0.09396431,0.10016362,0.015169619,0.06869789,0.039096657,-0.042621948,-0.039215952,0.00019976588,-0.08705543,-0.079888284,-0.12351023,-0.025061006,0.009137334,-0.022107728,-0.041765556,0.007331656,0.008273655,0.03285379,-0.034723587,-0.023725886,-0.03803711,0.0019109291,0.06609701,-0.0071854414,-0.051987935,0.07259803,-0.016578237,0.082573,0.010788999,-0.08180915,0.074158326,0.023636123,-0.08771807,-0.0037772062,0.038031664,0.027334569,0.108036295,0.091275774,0.010326058,0.07298823,-0.044380713,-0.028109767,0.06751438,0.017910847,-0.042866714,-0.06373578,-0.004031143,0.07821333,-0.037386563,-0.12634712,0.00901264,0.042400323,-0.00024860413,-0.10454879,-0.06140738,0.01614375,0.054645088,0.03183539,0.0077439845,0.031179927,0.015669439,-0.049476672,-0.018219631,-0.07575097,0.022209696,-0.0056003425,-0.07573885,0.0187117,0.08659568,-0.03377237,0.0018057986,0.0007632535,0.0134302145,-3.4024423e-33,0.07110339,0.020612355,-0.020301722,0.01690555,-0.048927177,0.0044570505,0.021019666,-0.04604172,0.02953722,0.014606839,0.056430075,-0.021702064,0.07947381,-0.0021126973,-0.035181157,0.016642226,-0.032367047,0.0906874,-0.004154921,0.0030548575,0.037483037,0.062405556,-0.012307281,0.011406612,0.06743153,0.009586887,0.04693767,0.10888771,0.025822,0.031044573,0.0034911975,-0.0069578663,-0.02093717,-0.040835083,-0.104675665,-0.0037700124,0.012943791,0.012425275,0.008744685,-0.002243958,-0.022261966,0.05044755,0.042544354,0.07614801,-0.032896914,0.057617463,-0.03108528,-0.026364177,-0.064721964,-0.021366164,0.06153912,0.009395199,-0.02478649,-0.043266013,-0.020435948,-0.0322945,0.0022653309,0.0014015349,-0.05280111,-0.0043048924,-0.032661516,-0.08292322,0.054229867,0.031067448,0.014498681,0.038745668,0.043965682,0.008662291,-0.0026996147,0.015646635,0.00013571682,0.014450101,0.09212215,0.04868542,0.007742674,0.050579436,-0.053688377,-0.0051870123,0.025877437,-0.13180389,0.022084488,-0.04951161,0.056931403,-0.06986606,-0.0060467976,-0.10949887,0.023209762,0.12187199,0.014356524,0.0413065,-0.046293754,-0.003952916,-0.02870944,0.10398314,0.06695638,-4.549565e-08,0.012249829,-0.062783934,-0.018303588,-0.04002761,0.014106881,0.066115014,-0.008831438,0.00015505224,0.053080503,-0.059578497,-0.0012826311,0.052619588,-0.08167264,0.053076994,0.0044581317,0.032763194,-0.025773289,0.02138907,-0.02448992,0.0066939984,-0.055064842,-0.012246037,-0.13686498,0.045032505,0.052343957,-0.024799462,0.016921796,0.08285322,0.023654012,-0.026106829,0.015460944,0.05156811,0.004482416,-0.108401485,-0.09922898,-0.04951961,-0.006463013,-0.030196497,0.020884499,-0.008775293,-0.008701695,0.021525923,-0.10717038,-0.017310116,0.044014014,-0.0043445188,0.008100945,-0.007229254,0.0007326936,0.038427614,0.09429725,-0.0049428768,0.048835177,-0.049573936,-0.10807514,0.01149447,-0.025121568,-0.034033418,0.01323792,-0.05856428,-0.036046144,0.027759776,0.14486574,0.00015271369 +3.2.1.164,"The enzyme specifically hydrolyses 1,6-beta-D-galactooligosaccharides with a degree of polymerization (DP) higher than 3, and their acidic derivatives with 4-O-methylglucosyluronate or glucosyluronate groups at the non-reducing terminals [2]. 1,3-beta-D- and 1,4-beta-D-galactosyl residues cannot act as substrates. The enzyme can also hydrolyse alpha-L-arabinofuranosidase-treated arabinogalactan protein (AGP) extracted from radish roots [2,3]. AGPs are thought to be involved in many physiological events, such as cell division, cell expansion and cell death [3].",384,0.9999999,-0.049415722,-0.103656046,-0.04799634,-0.0072617377,0.07720372,-0.004130396,-0.044166222,0.07489715,0.0768937,0.038348872,0.047584385,0.105513155,-0.03408866,0.005883148,-0.105732255,0.049433216,-0.014534694,0.031359162,-0.07252597,-0.015726244,0.066225424,-0.03790436,-0.050705507,-0.009702574,0.11783958,-0.04899947,0.004796107,-0.052172363,-0.059686087,-0.014202767,0.037350602,-0.036615554,0.076400004,-0.012973618,0.016116478,0.11173886,0.00010791813,-0.05773935,0.008542387,-0.08078185,0.09790215,-0.021240674,0.07443935,-0.06350368,-0.013866687,-0.041388348,-0.05706485,-0.005410624,0.052880738,-0.027017517,-0.0074528204,-0.07944282,-0.025656052,-0.00607598,-0.017451884,-0.018220833,-0.045284197,-0.06619285,-0.02109534,0.063778915,-0.0021778352,0.041544903,-0.016011741,0.002642014,-0.049474437,-0.058754586,0.06105276,-0.055350333,-0.043726344,0.057167638,-0.031682134,-0.00964035,0.0075398968,-0.018329766,0.05945667,-0.008063589,-0.041448858,-0.017697103,0.0631298,-0.015257976,0.02250442,0.01696247,0.10181582,0.029377576,-0.053064283,-0.043106385,0.07205366,0.076154195,-0.027693124,0.016661508,-0.014414537,-0.013141828,0.007594284,-0.026222045,-0.051618714,0.03264513,-0.0064771087,-0.10135238,0.004726753,-0.005040548,-0.042321045,0.0051437207,0.05823358,-0.06855864,-0.04823754,0.049912296,-0.0775054,0.035775926,0.0138175655,0.018516133,0.0016861188,0.03133378,-0.005228896,0.013967945,-0.05739391,0.06730584,-0.023619821,-0.13617994,-0.018018179,-0.040506743,0.00088717515,-0.023986362,0.09419527,0.033675198,0.039397437,0.063076794,-0.03350196,8.423252e-34,0.05933724,-0.06440151,-0.008516223,-0.047585834,0.02664001,-0.013454685,-0.030731637,0.004095165,0.016661398,0.026177673,-0.050880983,-0.071348414,0.027172195,0.051098272,-0.0317593,0.059907172,0.014482218,-0.052904762,0.027939823,-0.023346355,-0.0091874655,-0.0063389735,-0.0007703688,-0.028297609,0.093683034,-0.0072153015,-0.03367035,0.032697216,0.08447758,0.012482036,0.0071501234,-0.035539363,-0.14083292,0.032137383,0.0023101275,0.11903847,-0.09523149,-0.086325735,0.020306127,0.04847709,0.039006762,0.008785496,0.032485396,-0.013027996,0.072822355,0.058141273,-0.023626937,0.029962704,0.017408997,0.095172375,0.030208975,-0.016625598,0.09422134,0.008520966,-0.0001510565,0.03280635,-0.062189095,0.0041470258,-0.018273365,0.016681263,-0.030939996,-0.0125901345,-0.028710652,0.028042985,0.0004337404,0.082094766,-0.0395395,-0.023649603,-0.022163931,0.011564427,-0.025914127,-0.031875063,0.020586131,0.033181872,-0.032071065,-0.06655095,0.061794847,0.06262957,-0.011284475,0.080544844,0.0040470837,0.01429304,-0.030800661,0.005897654,-0.056658283,0.06223926,0.024203958,-0.024573904,0.030911952,-0.0070969365,0.05159008,-0.030721698,-0.02928323,0.07997688,-0.007526845,-2.5743043e-33,0.08058653,-0.09189131,0.0448518,-0.018566392,-0.0015818777,0.030640041,0.09743726,0.052632634,0.038725194,-0.09043016,0.02536184,0.03854246,-0.027924556,-0.08943522,0.034242764,-0.03669866,-0.017159836,0.08190794,-0.024983453,0.04445547,-0.07434118,0.14944689,0.037290752,0.023952447,0.072884984,-0.079794884,-0.011153351,0.05552971,-0.0372669,0.043424543,0.045142632,0.06465982,-0.084986374,-0.05391909,-0.059673093,0.014142125,-0.07963655,-0.020542838,-0.010534852,0.027045185,0.032179017,0.08969072,0.009869807,0.037421014,0.061953925,0.09554909,-0.07662988,0.027483022,0.020567486,-0.103011906,-0.046036404,-0.047028124,0.04434565,0.078681774,0.054743912,0.051272932,0.08406597,0.04514657,-0.058171496,-0.06465808,-0.05980948,-0.045903064,0.08617191,-0.021658612,0.030062156,0.06160215,-0.0007687009,-0.004970669,-0.005043996,0.029397236,0.027767219,0.013604776,-0.034404423,0.042790163,0.0126437815,0.044741664,-0.12364992,-0.022474375,-0.057629205,-0.048551634,0.07040819,0.08229821,-0.0634409,-0.0271644,-0.020513957,-0.017342504,0.054007474,0.14158528,0.0033724795,-0.020551536,-0.053009886,-0.015093244,-0.06213215,0.07351116,0.05513948,-4.0546215e-08,0.005007796,0.039051767,-0.012157237,-0.116369784,-0.044574685,0.036781963,0.019628352,0.047757093,-0.023153748,-0.017188178,-0.07480971,0.12440722,-0.05179201,0.011828515,-0.02287388,0.00021975438,0.018297791,0.011903945,-0.012942301,-0.0043685576,-0.1033639,0.00020641903,-0.07833677,0.009870976,-0.047764838,-0.024113012,0.04411824,0.03885,-0.012273945,-0.04884978,0.036434304,0.05278359,0.00096446514,-0.0001705396,-0.05237633,0.011071515,-0.06262805,-0.048142105,0.03648243,0.00062554213,0.03251113,-0.002660914,-0.00079925277,-0.04166008,-0.07236799,-0.016942296,0.014518205,0.01354709,-0.06203706,0.07377781,0.04819517,-0.042860582,-0.118127234,-0.0628506,-0.0037517478,-0.07301803,0.006500457,-0.06568759,-0.022897309,-0.017144918,-0.00353047,-0.07669271,0.09919429,-0.0094911875 +3.4.15.6,The enzyme is highly specific for the branched polypeptide cyanophycin and does not hydrolyse poly-L-aspartate or poly-L-arginine [3]. A serine-type exopeptidase that belongs in peptidase family S51.,384,1.0,-0.026580008,-0.0905724,-0.09834703,-0.055993784,0.107525624,0.057925936,0.0062936367,0.07969008,0.040276248,-0.008612901,0.024980282,0.03774108,-0.0436884,0.07611525,-0.054306045,0.030391831,-0.081744716,0.018831465,0.03346247,-0.020812616,0.11050151,-0.0004320414,0.03682055,0.04336923,0.024314873,-0.040912658,-0.040415723,-0.04450604,-0.026668837,-0.051123045,0.035677843,-0.050200175,0.04614934,-0.02263288,0.12708107,0.021166785,-0.05551012,-0.012566206,0.071661465,-0.017390141,0.052032936,0.019220594,-0.045764957,-0.036215406,0.022569934,8.371717e-05,-0.0029509903,0.044312596,-0.011954962,0.026944423,0.019764088,-0.09480907,-0.031651434,-0.052255176,-0.025720347,0.05908938,-0.07437889,-0.02955564,0.033693064,0.063783884,0.05755338,0.03790002,-0.0044400156,-0.05634945,-0.023029912,-0.040579163,0.034910772,-0.063299656,0.085869685,-0.032208186,-0.03327779,-0.041978344,-0.06044381,0.07401427,-0.007603965,0.0067026853,-0.032530695,-0.012628602,-0.08649039,0.009492016,-0.00062163005,-0.019706922,0.019262694,0.055972215,0.08301785,-0.017846344,0.0112569,0.078604214,0.037265036,0.01928819,0.0022996634,-0.06528351,-0.028262528,0.00052031956,-0.003880994,-0.026974838,-0.0077656913,-0.0045552133,-0.025639346,0.037965212,0.009838248,0.013301755,0.009018286,-0.1322788,-0.007914745,0.03349371,0.04064475,0.030247035,0.024756081,-0.08532521,-0.09270077,-0.034611247,0.01819008,-0.032267522,-0.0134174405,0.039037716,0.009316621,-0.061104327,-0.028293196,0.002416238,0.0070748813,0.021648737,0.06569663,0.09280264,-0.015847653,0.09314546,-0.1096084,1.6411189e-33,0.025560975,0.020809468,0.08236537,-0.008358833,0.0076666204,0.052468814,0.020866726,-0.029432977,-0.0044959723,-0.05321348,-0.11832668,-0.07883021,0.038774863,0.027172426,-0.018437574,-0.0011519485,-0.07196107,0.03759717,0.025426634,0.034033626,0.0460714,0.075692855,-0.0518899,-0.02999114,0.023790063,-0.014754773,0.0016481521,0.010698424,0.13705394,0.015733428,-0.047748566,-0.07708227,-0.107825145,0.0051084026,0.070618376,-0.01452822,0.026723957,-0.095014535,0.05625334,0.06871292,-0.086723804,0.022054475,0.052512918,-0.023615556,0.033478536,-0.013427668,-0.023543105,0.058294334,-0.015900312,0.033920765,0.047382027,-0.023458086,0.06210921,0.023746185,-0.046310913,-0.003798981,0.004714259,0.10373298,0.03355477,0.039698508,0.060842164,0.021701321,-0.029209718,-0.058186173,0.010719413,0.06147452,-0.039596077,0.034116514,0.0055459877,0.05712531,-0.070081465,-0.018101415,0.07480251,0.04592478,0.10419975,-0.08103465,-0.0912175,0.07252182,-0.0019594582,0.020580892,-0.030733928,0.02067922,-0.02469255,0.041021917,-0.04451521,-0.0065242313,0.03906987,-0.017764373,-0.051870566,0.0677359,0.038027637,-0.08743844,0.011694657,0.05858062,-0.03119518,-2.1488073e-33,0.029402707,-0.051560644,0.018925264,-0.0807049,-0.048248272,0.051835056,0.028176509,-0.020889413,0.030479899,-0.053931866,0.107453585,-0.03273562,0.028611729,-0.029897999,-0.02020631,-0.030442974,-0.051419724,0.07944564,0.011050002,-0.0019497823,-0.03132512,0.004893684,0.027139967,0.04390539,0.05831345,0.033287328,-0.039855402,0.10861857,0.024113575,-0.014061338,-0.07675302,0.028116416,-0.060465734,-0.06082608,-0.08692917,0.031268515,-0.09035199,-0.03766391,0.006106434,-0.02177356,0.012212276,0.024152875,0.045870677,0.08892693,0.04514822,0.06560327,-0.072405644,-0.005626035,0.04425257,-0.056395132,-0.024109257,-0.030792091,0.014375055,0.024549384,0.05550589,-0.027722722,0.0018418428,0.065086894,-0.090231575,0.017920626,0.0049272296,-0.035106927,-0.0020455397,0.064714745,0.075561136,0.028485762,-0.021071283,0.04659773,0.03559257,0.006862846,0.051813643,-0.030563843,0.0066244514,0.0971962,0.033455074,-0.012282299,-0.053877655,-0.040861517,-0.01584646,-0.116331495,0.016279142,-0.02385797,-0.057164457,-0.018784905,0.013958193,-0.047091737,0.007374584,0.07459698,0.033279344,0.032555085,0.0012025231,-0.0017811434,-0.02632096,0.09183629,0.05493833,-3.501372e-08,0.109770544,-0.007960151,0.004926079,-0.06518552,-0.052218255,-0.009731396,-0.021689277,-0.04566135,-0.025658084,-0.089668125,0.051178508,0.01933547,0.010026093,0.015918372,0.027414877,-0.0064799474,-0.037015144,0.061101582,0.0029865932,0.016322978,-0.13248044,0.036733065,-0.11157136,0.015505246,0.003177638,-0.039194148,0.0535527,0.068209685,0.024214663,-0.015921172,0.038714122,-0.02892955,-0.07038745,0.00084930327,-0.04188271,0.07978567,-0.11465697,0.00028254665,0.00697562,-0.01905868,-0.0055782986,-0.02235303,-0.059810366,-0.01161169,0.04512338,0.0046835635,-0.0026324997,-0.039787516,-0.033268526,0.0067603933,0.0052484586,-0.0006638059,-0.030785687,-0.06548478,-0.121250965,0.047827814,-0.041881677,-0.09630878,-0.029972237,-0.135512,-0.015045979,-0.023446266,0.18999177,0.040906392 +3.4.22.67,"This enzyme is found in ginger (Zingiber officinale) rhizome and is a member of the papain family. GP-II contains two glycosylation sites. The enzyme is inhibited by some divalent metal ions, such as Hg2+, Cu2+, Cd2+ and Zn2+ [2]. Belongs in peptidase family C1.",384,0.99999994,-0.08985861,-0.05071483,-0.13330565,0.028982999,0.10606797,-0.012494642,-0.0076744393,0.04568224,-0.026600122,-0.07889541,-0.020472074,0.022077058,-0.038647305,0.04002809,-0.06400857,-0.023277154,-0.0020931975,0.007128824,-0.027292171,-0.04523628,0.001239841,0.040300682,0.06637308,0.04349374,0.012428838,0.0101899,0.060145,0.020457821,0.032289974,-0.030325234,0.023583325,-0.042039286,0.036774114,-0.00962425,0.008972807,0.036210846,-0.029742835,-0.029868577,0.010177467,-0.04041088,0.086565726,0.013949643,0.05659844,-0.067267805,0.06413033,-0.03332361,-0.042838622,0.028673282,0.013419866,0.01711275,-0.077810995,-0.06400593,-0.0019383539,0.0381356,0.043607526,0.06995075,-0.03216972,-0.0715973,-0.016621174,0.013419751,0.06823207,-0.0330742,-0.07677161,-0.0098728705,-0.10025208,-0.008825184,0.07614955,-0.04307352,-0.016212996,-0.04706424,-0.038756203,-0.032862406,-0.07007773,0.009204996,0.009211672,0.054629385,0.023866706,-0.07701399,-0.008491619,-0.04248675,0.08637745,-0.006129751,0.1389815,0.0996268,-0.028949061,0.03207358,0.066212654,0.039884172,-0.021566102,-0.022356141,0.05511375,0.040305067,0.038215395,0.0024996153,-0.07854386,-0.009287387,-0.04520739,-0.008416926,0.0028938374,0.014346407,0.0602949,-0.003863098,-0.0023445138,-0.081970505,-0.095599234,0.096762024,-0.08506222,0.09256487,0.031686224,0.032784753,0.03546101,0.03512456,0.041458048,-0.044609297,-0.04100086,0.060091477,0.063274466,0.021588469,-0.0638132,0.046765044,0.013250659,-0.0014306372,0.027556995,-0.04499608,-0.030014934,-0.030338436,-0.12009893,3.381582e-33,-0.016393475,0.032595232,0.02367324,-0.05208555,0.012299554,0.049107186,-0.09109049,0.031487197,-0.03313078,-0.08251669,-0.060867906,-0.0062036626,-0.0527096,-0.008475899,-0.044359174,0.028354628,0.014213796,-0.02527606,0.013877682,-0.005176858,0.044361316,0.059846267,-0.053330634,-0.023718836,0.053960565,0.096602395,0.0016291979,-0.06664735,0.030019034,-0.016199537,0.033904925,-0.082508296,-0.104018696,0.103134885,0.056524612,-0.005621666,-0.00053678727,-0.06243435,0.053201456,0.06713648,0.034021985,0.0015580774,0.025353912,0.008366,0.04348696,-0.070500776,-0.03335256,0.068838276,0.04797849,0.075674556,0.015088256,-0.0369707,-0.002082998,0.10150936,-0.10136867,0.008461197,-0.045418695,0.077107236,0.13283488,0.021495095,0.0068083755,0.030789686,-0.014886225,0.023535423,-0.018148936,-0.010667006,-0.09660655,-0.04738739,-0.033116173,0.10880294,-0.03943936,-0.021720126,0.10050986,0.052061386,0.06389842,-0.13177754,-0.008427468,0.034739777,0.07341573,0.051926635,-0.054188997,0.00782734,0.011238201,0.020907342,-0.12789555,-0.076736726,-0.067855634,-0.026439352,-0.07135822,0.038293246,-0.02744302,-0.027016038,-0.101010986,0.023059519,0.0029857927,-5.212605e-33,0.1024647,-0.053452026,0.09814295,-0.010040669,-0.040741947,-0.029921569,0.040483393,-0.045064252,0.051897947,-0.052549377,0.09353472,0.044654153,0.069590434,0.040400032,0.05914848,0.019146597,0.01237066,0.097568005,-0.03753661,-0.009468016,-0.042305354,0.019683817,0.007084584,0.046367344,0.023258667,-0.014119319,0.038932458,0.0083565945,0.026208842,0.08962231,-0.0013443234,0.06515228,-0.09076763,-0.1228759,-0.06338424,0.03631211,-0.028692218,-0.034301285,-0.082675286,0.017153881,0.008979087,0.009031272,0.044174775,0.07684502,0.06004366,0.052520417,-0.03279671,0.06640381,-0.038334087,-0.048547402,-0.0017704312,0.028697336,-0.008231798,0.04625549,0.051552594,-0.019117488,0.019443855,-0.021408098,-0.03715918,0.060726766,0.01406726,-0.011951826,-0.029295431,0.039513975,0.044081327,0.014813407,0.032673478,0.031184364,0.07306826,0.034740906,0.056844864,-0.0054839617,0.044887062,0.015441494,-0.097914256,0.07222424,-0.086999275,-0.010082585,0.02690673,-0.052349333,0.052898232,-0.017420022,0.037842657,-0.027686803,-0.014294735,-0.10455781,0.0023977207,0.08381658,0.0013977762,-0.035208352,-0.029978652,0.0492727,-0.024091685,-0.001381295,-0.01608707,-3.655113e-08,0.0654497,-0.12173017,0.068228,-0.07597715,-0.03231102,-7.835631e-05,-0.0109969955,-0.035666205,-0.024339285,-0.00918998,-0.041458037,0.04143486,-0.012400115,-0.07503474,-0.041800324,0.054946516,-0.02101026,0.04129052,-0.025234604,0.041592903,-0.06634325,-0.0054404424,-0.10075343,-0.04602296,-0.058070183,-0.041732505,0.04279787,0.029543718,-0.016438695,-0.012072776,0.06513613,0.032821815,0.029501373,-0.00803426,-0.022619553,-0.041796304,0.027413841,-0.01707087,-0.012556303,-0.12135959,0.037423626,-0.035237405,0.0033212334,-0.02862079,-0.02963063,-0.0048304503,0.029514868,-0.04597519,0.02571727,-0.023727067,-0.0021113432,0.013065265,-0.047733307,-0.03574441,-0.073621735,-0.0027282194,-0.018583773,-0.038973257,0.0117085,-0.07069417,-0.04225696,-0.012141416,0.08781232,0.005785212 +4.1.99.12,"Requires a divalent cation, preferably Mg2+, for activity [1]. The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5 [1]. The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin [1].",384,1.0,0.02769109,-0.06744634,-0.030700278,-0.014527654,0.0022556682,0.056854114,-0.06163568,0.03520441,0.010942956,0.04101588,-0.03455462,-0.0063613662,-0.0061503034,0.04717075,-0.077217646,0.019290876,-0.048594233,0.06505158,-0.02679824,0.019847436,-0.0013318113,0.035047088,-0.0052259373,0.00068902504,0.07339801,-0.02858341,0.037337724,-0.048325747,-0.0050637927,-0.017420609,-0.008396338,-0.008373386,-0.003598779,-0.042916484,0.0014375686,0.14177848,-0.037768655,-0.057062063,0.029390128,0.035684332,0.012382289,-0.008280494,0.008532938,0.0075266473,0.028892765,-0.010080139,-0.05333511,0.08747831,0.07748269,0.031522445,-0.059286218,0.0061967024,-0.05119417,-0.0076247063,0.059447423,0.014181127,-0.008383324,0.00094837,0.05174703,0.03182051,0.056090876,-0.03084063,-0.019390313,0.014225426,0.07135894,-0.05380958,0.06763362,-0.027315482,0.014975843,-0.010683518,0.0028405827,-0.026982058,-0.014373827,-0.012777357,-0.04636019,0.042005926,-0.012881607,-0.03327009,0.020306304,-0.017829297,0.047665168,0.04018622,0.04316167,0.014045681,-0.0010594084,0.048639424,-0.024837604,-0.019142695,0.03798193,0.073547594,0.009548164,0.027048647,0.021550402,-0.032226842,-0.07581707,0.024531573,0.03937066,0.012302047,0.023613457,0.025757415,0.007182624,0.0732622,-0.025300121,-0.07619129,-0.039627608,0.02256684,-0.06495716,0.038008112,-0.0507855,0.012898083,0.03932384,-0.016275797,-0.075428806,-0.0023572866,-0.020027172,0.09521488,0.049752153,-0.096739605,-0.07181748,-0.039737098,-0.00950332,0.0050949496,0.031601686,0.017681308,-0.1371028,-0.071246386,-0.024848746,2.6664695e-33,0.050486527,0.009273051,0.046924025,0.03373834,0.0025264737,0.019161858,-0.15537487,-0.022321116,-0.014700296,0.0036345473,-0.11477431,-0.07415534,0.077678666,-0.06763989,-0.025082352,-0.101818465,-0.0015905123,0.0009565483,0.0532965,0.0046074083,-0.04091371,0.13789362,-0.014405904,0.08302093,0.047232565,0.08912724,0.046019536,-0.048502613,0.052548602,-0.022449993,-0.0043327925,-0.02192318,-0.05638761,-0.017079674,0.023982478,-0.10935992,-0.070239045,-0.038726065,0.028703988,0.027458392,0.056102905,-0.054636493,-0.075306065,-0.008358195,0.07543155,-0.038291078,0.02444289,0.017308936,-0.035835847,0.013549796,0.09120635,0.029605998,0.05344168,-0.043991692,-0.10770698,-0.01709432,-0.035806715,-0.045186054,0.09488255,0.04654462,0.010954753,0.033166792,-0.0028461288,0.026183339,-0.025315711,-0.032028764,-0.096471794,-0.083806366,-0.009052053,-0.048283223,0.0153849535,-0.08005448,0.10312534,0.0011273985,-0.0014351254,0.033793736,-0.052175514,0.0010752619,-0.033128437,-0.020592524,-0.013168264,0.06396363,0.013896169,0.03408737,-0.00030225774,0.01965462,-0.017740324,-0.14075173,-0.009375573,0.042562366,0.010967275,-0.05994349,-0.03910368,0.027799405,0.074835055,-4.94764e-33,0.11552669,-0.10503473,0.07945256,-0.043767918,-0.0706929,0.030567784,-0.010913488,-0.07695664,0.004431362,0.0211097,0.044974644,-0.0048281695,0.008564637,-0.008935,-0.034205142,0.038490172,0.02411465,0.034172114,-0.09899498,0.028810605,0.07028494,0.015655113,0.017297478,0.05802809,0.03738834,0.07535618,0.06523529,-0.06269536,0.04260818,0.09460011,-0.021234188,-0.024865432,-0.018938644,-0.008644057,-0.0054230355,0.09437575,-0.017014515,0.030887194,-0.0051612626,0.06407734,-0.10101286,0.09204942,0.031499457,0.058242287,0.04892804,0.0025212467,-0.018007332,-0.0016982906,-0.05211561,-0.07039253,0.054726597,0.0061192783,-0.0009293614,-0.010050981,0.00432898,0.020831374,0.049526244,-0.00017796569,0.05562363,-0.017510444,-0.032437555,-0.08794052,0.06279725,-0.03221569,0.08692362,0.07068221,-0.027570726,-0.017330678,0.014252465,-0.076109044,0.0727359,0.034295153,0.045261122,0.01586527,0.022461616,-0.005644055,-0.0148247015,-0.07901998,-0.043944262,-0.02885778,-0.06671883,-0.0011627488,0.02661058,-0.04745971,-0.045090735,-0.20333914,0.05939497,0.09781794,-0.022440827,0.0010397256,-0.013892779,0.029561682,-0.018063175,0.047362357,0.121246934,-4.5688548e-08,-0.023201333,0.041572545,0.014145086,-0.067828014,0.014421943,-0.020138398,-0.022208061,-0.020701535,0.06306392,-0.06720523,-0.029308202,0.03745692,0.005499302,-0.003003187,0.056387473,0.024412388,-0.13167033,-0.04532383,-0.038477436,0.0014987703,-0.024941469,0.0026663956,-0.07393351,0.0007850965,-0.06782139,-0.086562306,-0.036122173,0.027906839,-0.001942322,-0.009460198,0.0668826,0.09261493,-0.00027608097,-0.09135889,-0.07036064,-0.012742923,0.020870365,0.023169098,-0.020757556,-0.011645469,-0.077513844,-0.04879975,0.0013693235,0.07756725,-0.082747445,-0.050839517,-0.049289595,0.07778009,0.0061343415,0.033980723,0.08558991,0.06250159,-0.08395868,-0.07721213,-0.054873448,-0.023005376,-0.024608068,-0.03755416,0.00499373,-0.06412681,-0.06602829,-0.068626605,0.06982444,-0.02668768 +6.1.1.26,"In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNAPyl, with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl---tRNA ligase. The enzyme is specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids [1].",384,0.9999999,-0.034276616,-0.058554407,-0.12636772,-0.088452764,-0.031013953,-0.0029213545,-0.0024771497,0.006254105,0.0067652306,0.035860408,0.055333275,-0.039511915,-0.045286212,0.05864448,-0.057425886,0.02112006,-0.093457535,-0.03537783,0.055884752,0.01735919,-0.022679817,0.111163676,-0.021317592,0.0142332995,-0.0763619,-0.04786505,0.06907206,-0.022780668,-0.0151631255,-0.05105408,-0.044724133,-0.014766666,-0.01969168,-0.031530675,0.06956873,0.09110005,-0.1023061,0.035208594,0.06534618,0.011962932,0.07374051,-0.0051185153,0.0022759703,-0.027961459,-0.08540923,-0.048903923,0.08885266,-0.001782791,0.015434239,-0.024498317,-0.004193288,-0.061737794,-0.030683009,0.008672256,-0.03137959,0.04999894,-0.045817528,-0.002478323,-0.022049315,-0.043733552,0.010557818,0.057240076,-0.0032651625,-0.028031316,0.024665512,-0.038494535,0.06153055,-0.017810864,0.15219744,-0.04708825,-0.046556666,-0.01624488,0.058182545,0.017507182,-0.038314573,-0.025028227,0.027331855,-0.021871446,0.0009724069,-0.0033635418,-0.09205267,-0.025684139,0.019631395,-2.409318e-05,0.1179132,0.04033172,-0.06502508,0.021374188,0.024800057,0.03492206,0.09130367,0.02715628,0.038318053,-0.050092973,-0.042425483,-0.026393306,0.04499344,-0.0047877813,-0.005454546,-0.0061481865,-0.010597025,0.054904167,-0.12332368,-0.029340604,-0.04422635,-0.057593364,0.032290492,-0.02293398,-0.024928082,0.020777473,-0.022843141,0.057983767,0.039104212,0.021202443,-0.024706606,0.036558263,0.08414242,-0.032743827,0.03617704,-0.031288948,-0.010773062,0.00601153,0.051841196,0.04520189,-0.024929112,-0.006758271,-0.026376024,3.8265673e-33,-0.017157141,0.01162924,0.036892127,-0.01455336,0.09600219,0.014938237,-0.08572694,0.017204715,-0.00026933503,-0.09648507,-0.07474986,-0.06304301,0.009100909,0.03623449,-0.01723819,-0.022016978,-0.08836997,0.026490126,0.061326824,-0.044286337,0.0072400467,0.11825015,0.019741913,0.029569102,-0.0111863455,0.059915166,0.011208934,0.046342064,0.09361014,0.016886055,0.020479342,-0.079676524,-0.048274368,0.00055184244,-0.00893265,0.032267664,-0.054075938,-0.027805936,0.018803678,0.08747539,0.024839314,-0.06731438,0.025213568,0.0061170105,-0.04046101,-0.0498907,-0.06136515,0.09060676,-0.07284594,-0.037853297,0.035905577,-0.053327594,-0.012802974,-0.031709448,-0.088381276,-0.027719203,0.0049735284,-0.07413545,0.04967415,0.11547624,0.04823155,0.050522506,-0.024039913,0.027344653,-0.071461864,-0.078171685,-0.017805267,-0.05331539,0.022831252,0.022543237,-0.041789304,-0.0013301747,0.030604191,0.039454445,0.042673815,-0.059198562,-0.068977244,0.055821065,0.00030857572,0.043215103,0.0029746473,-0.035908174,0.012983952,-0.00046966333,0.0017003875,-0.057090316,0.015609446,-0.051796027,0.02227806,0.024215164,-0.054965183,-0.055235084,-0.08434527,0.011683577,0.059009794,-5.542723e-33,0.024279477,-0.07128283,0.077807665,-0.032721747,-0.08045498,0.014477405,0.043514967,-0.09003994,0.0039582327,-0.09196839,0.07557445,0.0041792225,-0.019603217,-0.0033775948,0.06747544,-0.012742349,-0.040393732,0.030782877,-0.012254072,-0.06765387,-0.006660054,0.0031730586,-0.018983802,-0.002793189,0.046993602,-0.027940981,-0.03664388,0.096907906,0.026987948,0.06975121,-0.017039312,0.0068421145,0.002746682,0.02223559,-0.136929,0.028766066,-0.040824857,0.0060978625,0.01921565,0.011425556,0.09740155,0.026341325,0.008100493,0.035889957,-0.05112394,0.04984613,-0.07068359,-0.035344254,-0.011507355,0.0010031176,0.11010467,0.051423453,0.05402339,-0.008023426,0.076060586,0.0412585,-0.01817611,-0.044043288,0.03682108,-0.037141856,-0.021668846,-0.06707172,-0.029336978,0.020860363,0.061490577,-0.026813423,0.012626294,0.09791777,0.056750994,-0.03395025,0.08403181,0.068916366,0.03867983,0.047055777,-0.090619616,-0.022656785,-0.04425796,0.05110248,0.065216005,-0.068854675,-0.02286881,-0.055747297,0.06492242,-0.06645886,0.027098488,-0.046846405,0.077590674,0.090351366,0.024191415,0.02909061,-0.008570117,-0.0024041294,0.014892488,0.044153824,0.09127213,-4.1278078e-08,0.0053900806,-0.0753341,-0.018037014,-0.017850472,-0.016597496,0.042565998,-0.05168765,-0.0051756687,0.014321577,-0.026647544,-0.038797826,0.03433461,0.033065055,0.03940324,-0.03766883,0.13833754,-0.05032776,0.009997421,0.014535923,-0.055627484,-0.1319186,0.07049557,-0.12594344,0.026616404,-0.031922832,0.042978127,-0.015831843,0.0851026,-0.05463748,-0.029200323,0.00431352,-0.013686041,0.0065016276,-0.030980285,-0.022543615,0.03958158,-0.008005724,-0.051930316,-0.03176183,0.03707311,-0.011175445,-0.024952129,-0.044088818,0.009802171,0.013471677,-0.0410261,-0.037445262,0.05886886,-0.017618436,0.07202893,0.10724621,0.09514064,0.06569686,-0.05312016,-0.0914097,0.020315168,-0.044882804,-0.08797934,-0.10647181,0.02859814,0.059415698,-0.013037845,0.14297104,-0.009523711 +6.3.2.29,"Requires Mg2+ for activity. Both this enzyme and EC 6.3.2.30, cyanophycin synthase (L-arginine-adding), are required for the elongation of cyanophycin, which is a protein-like cell inclusion that is unique to cyanobacteria and acts as a temporary nitrogen store [2]. Both enzymes are found in the same protein but have different active sites [2,4]. Both L-Asp and L-Arg must be present before either enzyme will display significant activity [2].",384,0.99999994,-0.11937613,-0.073875956,-0.06219414,0.016281454,0.08889661,0.031560253,-0.009803865,0.0026346892,0.0020040337,-0.021224083,0.0681698,-0.02079964,0.016138654,0.0054766727,-0.033540446,0.060042363,-0.05761084,-9.6008895e-05,-0.009325998,-0.010220648,0.076640435,0.031585615,-0.027666872,-0.0007541267,0.10261446,-0.03908615,-0.008585909,0.062183287,0.007883135,-0.038658854,-0.019657496,0.0044400212,0.048640843,-0.040983133,0.12761417,0.044349514,-0.063936755,-0.048065163,0.023948934,-0.02697891,0.034917284,-0.026679825,0.00757641,-0.033127423,0.017579427,-0.025447479,0.07239289,-0.028109794,0.0044332184,-0.028955776,-0.0020203146,-0.03272571,-0.04913716,0.024058033,-0.029102635,0.0675876,-0.2141489,0.0036921373,0.004498586,0.024607737,0.05079746,0.035241317,-0.021975964,-0.003749078,0.032718677,-0.0666383,0.0097392285,-0.049287423,0.07552238,0.0036940132,-0.042507797,-0.05776013,-0.06514725,0.060617704,-0.038795356,0.010012315,0.012849262,-0.052638255,-0.0051364126,-0.030761248,0.025904007,-0.017553516,0.02765873,0.034457598,0.032055784,-0.06953756,0.04311422,0.070191115,-0.036436446,0.06579964,0.1373945,0.046676427,-0.022709176,-0.020579938,-0.00025559304,0.009508294,0.00890555,0.044439282,0.0032058894,-0.017516997,-0.0015051259,0.07693638,0.0022041993,-0.03482962,0.043070484,-0.013482788,0.013432911,0.019876549,0.021876384,-0.019927219,0.033252556,-0.014042868,-0.008830683,-0.0040693344,0.018024238,0.13371146,-0.00060389447,-0.1116129,-0.07108157,0.0024175844,-0.026372468,-0.033319227,0.019426303,0.07412028,-0.057575617,0.053266615,-0.11151096,1.4687572e-33,0.011056807,0.027640253,0.006322569,-0.023089772,-0.0023811872,0.0012426751,-0.044784404,-0.01538782,-0.044938017,-0.07473165,-0.1271224,-0.021415168,0.037568677,0.03889843,-0.06330993,-0.011917094,-0.015079272,0.030241184,0.059814747,0.026243621,0.00785611,0.013853555,-0.038050257,0.008800257,0.012241062,0.05891311,0.0449813,-0.053612538,0.060325317,-0.02373913,-0.03339765,-0.083165206,-0.041992348,0.03392112,0.10885257,-0.051505916,0.024696844,-0.05927935,0.045057975,0.026203224,-0.0640992,0.04653948,0.0018264756,-0.0073638083,0.07979956,-0.02975735,-0.053894315,0.040002417,0.01916691,0.052382495,0.10629632,-0.026754037,0.05954002,-0.00737988,-0.04293782,0.04201646,-0.057066146,0.060923617,0.059663855,-0.00097451755,0.013129335,-0.0006708902,0.00032672656,0.058696844,0.041113462,0.08759685,-0.09062844,-0.0463805,0.0040818253,0.078564584,-0.060935404,-0.12688747,0.12125678,0.035354123,0.10448092,-0.02764076,-0.11582358,0.04916123,-0.0001158886,0.026707398,-0.009470058,-0.041159943,0.008158703,-0.0038665188,-0.029999714,-0.09421181,-0.018547753,-0.051833328,0.08522806,0.06650186,0.07730352,-0.027241854,-0.06852982,0.07772777,0.0056674504,-2.7480411e-33,0.12105959,-0.041190512,0.023942512,-0.0430157,-0.07003184,0.09948524,0.019147897,-0.11853078,0.080901004,-0.014360954,0.10270511,0.0012947586,-0.0013937724,-0.035313226,-0.0003572728,-0.07928022,-0.031986687,0.09619155,-0.030642278,0.044073265,-0.026457509,0.0057568615,0.0031986474,0.04111265,0.049901508,0.019861357,-0.039814007,0.034559175,0.017300354,0.021421956,-0.04547615,0.025359318,-0.06195944,-0.073115885,-0.0027653459,0.020499863,0.009198851,-0.018512433,-0.035391606,0.0087066665,0.048517257,-0.0003736379,-0.0050627477,0.081048556,0.06769172,-0.00412938,0.03814835,-0.01103492,-0.05210673,-0.098812655,0.029468834,-0.028571306,-0.04447834,-0.01583544,0.014901731,0.05939607,0.030468177,0.04412752,0.039203584,-0.012645379,0.026139963,-0.10934392,0.015355454,-0.096126184,0.009031406,0.052284554,0.019399913,0.10651996,-0.010092209,0.016117126,0.048881967,0.00088237313,0.07355596,0.009772879,-0.028270932,0.042855248,0.020334408,-0.083011,0.029809622,-0.09357881,-0.051981553,0.020474691,-0.041200127,-0.046114158,-0.07260852,-0.02695542,0.03251636,0.096736416,-0.028235927,-0.035036173,-0.015217943,-0.009300057,-0.08492667,0.05584321,-0.008391847,-4.474523e-08,0.05186501,-0.0060710185,0.040682286,-0.05484034,0.023472091,0.04527755,0.010544945,0.00273056,0.059735447,-0.03149769,0.06177677,0.0072157644,0.0037999863,-0.06796119,0.012828048,-0.022180589,-0.05891427,0.023717023,-0.015168173,0.042010248,-0.06281972,-0.0057741865,-0.13868493,0.020662932,0.020557974,-0.091714256,0.01747118,0.099243194,0.0077058156,-0.04631567,0.056467365,-0.01017448,0.020821568,0.065299556,-0.060903717,0.0072370837,-0.053410612,-0.041195303,-0.036261514,-0.06541036,-0.07808658,-0.019795196,-0.01836022,-0.031125605,-0.025223548,0.034005363,0.03273953,-0.035916407,-0.029937796,0.017876321,0.0050549693,-0.07487359,0.003994482,-0.09462736,-0.015960578,0.046605244,-0.008434347,-0.037439965,-0.058175236,-0.07837008,-0.053581376,-0.03209549,0.0845542,-0.022587366 +6.3.2.30,"Requires Mg2+ for activity. Both this enzyme and EC 6.3.2.29, cyanophycin synthase (L-aspartate-adding), are required for the elongation of cyanophycin, which is a protein-like cell inclusion that is unique to cyanobacteria and acts as a temporary nitrogen store [2]. Both enzymes are found in the same protein but have different active sites [2,4]. Both L-Asp and L-Arg must be present before either enzyme will display significant activity [2]. Canavanine and lysine can be incoporated into the polymer instead of arginine [2].",384,1.0,-0.101474404,-0.07094989,-0.092762284,-0.0044579906,0.095910236,0.04487781,-0.023204852,0.023646552,-0.012889807,-0.018364597,0.049157564,0.022276182,0.043288603,0.02431542,-0.04604971,0.06768549,-0.03507843,-0.012370238,-0.0038703943,0.021840498,0.08890287,0.037462607,-0.033754896,-0.0020418533,0.102086835,-0.047976315,-0.0096893255,0.03423509,0.0013617805,-0.06288278,0.003919794,0.014477676,0.0119538745,-0.047097445,0.12114691,0.02903356,-0.09339512,-0.04424712,0.023643719,-0.033770695,0.03348658,-0.020905137,-0.030440811,-0.028458757,0.0067442395,-0.052634526,0.046995677,-0.01235912,0.025530042,-0.0063352,-0.0016726013,-0.022918483,-0.01674897,-0.004989737,-0.04022164,0.05224634,-0.23563735,0.0037844214,0.00470915,0.06326395,0.041501448,0.03275345,0.0040838937,-0.009752607,0.036088422,-0.06645309,0.007755442,-0.007090383,0.09524868,-0.012668514,-0.034623228,-0.06790873,-0.04320467,0.062355332,-0.009496337,-0.006400857,0.025063977,0.0031062053,-0.025398823,-0.020055119,0.044110667,-0.018946039,0.011737981,0.06942889,0.029329764,-0.05598251,0.02602117,0.12339214,-0.024278017,0.049548183,0.11647949,0.052875783,-0.0093310345,-0.032516494,-0.006786805,0.0010805007,0.014394281,0.014694518,0.010338643,-0.021599403,-0.013020107,0.04605594,-0.01088779,-0.04043819,0.011968512,-0.012295677,0.019247357,-0.00997032,0.055434205,-0.01837682,0.0058778897,-0.01798986,0.031929825,-0.0045685126,-0.013324973,0.096657656,0.031096738,-0.09402349,-0.08793445,-0.024276596,-0.017411595,-0.032777365,0.038388066,0.065260775,-0.04659017,0.08107709,-0.08738763,2.8659493e-33,0.024714727,0.03812013,0.0075188996,-0.016180454,0.0023949041,0.022232516,-0.009187571,-0.0054577324,-0.03497609,-0.09465911,-0.11148607,-0.04686147,0.026249306,0.03478836,-0.049523573,-0.02152212,0.0014842174,0.028032552,0.053990155,0.027743202,-0.012470845,0.027988883,-0.06804663,0.028395856,-0.014902873,0.060944222,0.033639554,-0.033746082,0.079664454,-0.033059884,-0.03539072,-0.088879675,-0.04468779,0.06349256,0.0825456,-0.056440998,0.010667182,-0.069836825,0.031116325,0.017165272,-0.05837185,0.058141366,0.014373501,-0.021108402,0.04180952,-0.021316923,-0.067486554,0.04645554,0.0015529403,0.07140131,0.09011297,-0.012023482,0.05642381,-0.03461688,-0.05039749,0.04716032,-0.054045767,0.060076624,0.07580508,-0.020832242,-0.0140756015,0.002241291,0.010882173,0.034328736,0.04129201,0.07341642,-0.09576189,-0.013009835,0.0056970627,0.04744424,-0.071021125,-0.10577483,0.10679006,0.050512966,0.09503029,-0.012382248,-0.13109958,0.0486696,0.017374406,0.0024703715,0.016524574,-0.044130735,0.00079577224,0.009896253,-0.022090258,-0.086818084,0.011526371,-0.06899277,0.074839674,0.064393245,0.052978925,-0.054901846,-0.03671495,0.0604828,0.0069679623,-3.9963263e-33,0.12598898,-0.04743913,0.040610738,-0.041728713,-0.038784113,0.07626028,0.023288589,-0.069351204,0.05776428,-0.032036494,0.098115414,-0.010057626,-0.008728059,-0.040121604,-0.02662496,-0.03880259,-0.008700349,0.12096146,-0.054757297,0.017975068,-0.047457658,-0.0073808827,0.0031464184,0.05307484,0.04409688,0.044722624,-0.00047290762,0.008348638,0.017805925,0.04660273,-0.019012334,0.023676714,-0.0808704,-0.0799181,0.03062071,0.024341997,0.0029025953,-0.06619291,-0.04716144,-0.024878405,0.036191043,0.017285543,-0.013147293,0.061422735,0.052728783,-0.0049057044,0.0049982388,-0.035925835,-0.023368709,-0.086702384,0.034632925,-0.01883603,-0.024358427,0.0010152617,0.012604251,0.043003157,0.085497834,0.0271055,0.02991017,-0.012334934,0.02806193,-0.10511125,-0.017429288,-0.07691061,0.009867961,0.06095446,0.01040822,0.116974026,-0.018832842,-0.019270938,0.06468441,-0.03043035,0.096566014,0.041979533,-0.028864507,0.034156844,0.021058021,-0.11974703,0.0065424955,-0.099816516,-0.052392337,-0.0012009074,-0.059444007,-0.04740678,-0.047198333,-0.02559728,0.04444291,0.08888446,-0.034166373,-0.029490784,-0.019527005,-0.014739894,-0.0790582,0.074206315,0.048052624,-4.922127e-08,0.055031702,-0.039542887,0.01687449,-0.06548888,-0.009260515,0.05827829,-0.0046368456,-0.021092093,0.048375133,-0.03888728,0.06059033,0.018714758,-0.032134973,-0.03413459,0.01704074,-0.008533224,-0.041422,0.033375278,-0.021498114,0.038590733,-0.09543574,0.011886553,-0.13176376,0.011100821,0.009134238,-0.0796929,0.018584864,0.1087054,0.049171425,-0.04625659,0.032395482,-0.0018273493,0.011847517,0.055886284,-0.084356114,-0.00047558924,-0.029458981,-0.030828083,-0.009524552,-0.04813742,-0.077321105,-0.010264555,-0.040085703,-0.013890592,0.0005999131,-0.00028795886,0.025269218,-0.00058501173,-0.06259488,0.022469677,0.012714848,-0.06783984,0.010880631,-0.10483164,-0.0284942,0.027173355,-0.021047214,-0.015418681,-0.03469776,-0.10301406,-0.076231495,-0.033557504,0.15350391,-0.011770985 +1.1.1.293,"This enzyme along with EC 1.1.1.236, tropinone reductase II, represents a branch point in tropane alkaloid metabolism [3]. Tropine (the product of EC 1.1.1.293) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [3]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [2].",384,1.0,-0.005464206,-0.080930255,-0.17578566,-0.033174817,0.0055081537,-0.01154889,-0.015705755,0.06918578,0.039900836,-0.059699792,0.03622058,-0.046572518,0.0035935738,-0.024262086,-0.025670484,-0.022147791,-0.08413025,-0.058386568,0.12283415,-0.06646678,0.04404804,0.031454094,-0.019607771,0.059503462,0.04753509,-0.0072673275,-0.01829218,0.028733471,-0.007948612,-0.007208293,-0.046150554,0.01457575,0.026242802,0.0025718885,0.011537556,0.09188665,-0.13804659,-0.017142106,0.0015476892,0.039858382,0.036619965,0.0037425521,-0.037734672,-0.0012461732,-0.0683286,-0.07169558,-0.026611539,0.10665532,-0.039340556,0.034586187,-0.035993237,-0.0051766937,0.02323353,0.11759074,-0.062439665,0.050615545,-0.046136037,0.073285,0.013289968,0.07186686,0.030850694,0.06380062,0.015362568,-0.07184088,0.037373204,-0.015455907,-0.017926775,-0.06536714,0.08607118,0.015017291,-0.04430417,-0.021696186,0.060065635,0.060243342,0.0020712405,-0.020559186,-0.0454304,-0.017293677,-0.10435191,-0.039518517,0.026190212,0.014578464,-0.0028035808,0.023766862,0.04000275,0.011175494,-0.0026980913,0.10366557,0.017021505,-0.0005052446,0.13229683,0.009574355,0.020717083,-0.06713869,-0.054972086,0.05142573,-0.009565127,0.044121485,0.025576433,-0.09281253,0.031552162,0.004520823,-0.08332062,-0.013932442,0.010871688,0.038765885,0.029471861,0.008640992,-0.038741414,0.009783126,0.043929335,0.006392685,0.04916217,0.016312659,-0.01912161,0.120136686,0.0032553654,-0.02826938,-0.0141432155,0.024818193,-0.034225006,0.03729232,0.033380095,0.040489055,0.037562937,-0.042867675,-0.14046398,3.1064797e-33,0.0023012012,0.051594876,0.0006909848,-0.0488489,-0.009665174,-0.007283732,-0.121010065,-0.019343067,-0.0005612046,-0.011611457,-0.107451215,0.011730225,-0.00075269834,-0.0020316844,0.046487223,-0.028052805,-0.04860014,0.0804814,0.08709658,-0.033033445,0.00041331706,0.075178094,-0.13408095,-0.0015788011,-0.033804998,0.07193752,-0.03222072,0.08307492,0.018820615,0.0076717413,0.0072876983,-0.07377717,-0.045494255,0.023435501,0.033320595,-0.059794124,-0.014960979,-0.00586714,-0.07479363,0.101003274,0.016852599,0.10555744,0.067074016,0.03018817,0.041970678,-0.053447135,-0.016094415,0.07808985,0.08855904,0.037189815,-0.04198053,-0.05998587,0.081090994,0.0021049029,-0.077829525,0.03471261,-0.006230976,-0.033117536,0.043178335,0.1008463,0.027263608,0.041992236,-0.017866462,-0.044742722,-0.058729004,0.020933243,-0.04052035,-0.10102052,-0.033039793,0.06813033,-0.13126324,0.023498278,0.083732225,0.023899911,0.088146366,-0.038155816,-0.026624339,-0.006467823,-0.06606011,-0.03029521,-0.036830205,-0.09345486,0.014661533,0.003625688,-0.016414762,-0.0010250392,0.004352306,-0.039547186,0.0035814948,0.061905544,-0.016675033,-0.038037803,-0.08666145,0.021834007,-0.02717006,-3.0167444e-33,0.0049139797,-0.054320212,0.103797294,-0.06503807,-0.05878932,0.092399776,-0.019663487,-0.089555815,0.02336455,-0.015056228,0.08908254,0.021244247,-0.022175124,-0.025729176,0.03440594,0.03958585,0.020283824,0.044604614,-0.013013165,-0.044262845,-0.07550267,0.042900648,-0.05738303,0.03518149,0.0020712994,-0.016140219,0.06899148,0.07101525,0.049005076,0.08291543,-0.029683335,-0.002025752,-0.08155158,-0.01807699,-0.025526281,0.01905849,-0.08952435,-0.0018321329,0.027788553,0.02333342,0.03909202,0.014478536,0.02682793,0.0270779,0.025820863,-0.005418092,-0.025220454,0.013509189,-0.054167297,-0.07991431,0.053605326,0.040653065,0.036355637,-0.025836408,0.0483623,0.0090582585,-0.04147606,0.046775386,-0.038189396,-0.039100617,0.041279558,-0.030373212,-0.023588005,-0.030728692,0.059224132,-0.026564261,-0.027596196,0.085603245,0.028073266,0.06559613,0.019804316,-0.0027301356,0.0036665334,0.05854051,-0.0504309,-0.021470157,-0.03378278,-0.047250267,0.07403007,-0.0222166,0.015286661,0.04998758,0.013625847,-0.104595974,0.008409912,0.05349517,-0.020055093,0.112988554,0.03776281,0.050447997,0.062985815,-0.024216259,-0.053346828,0.007302476,0.034228027,-4.1860318e-08,0.042629346,-0.027597161,-0.018016027,0.029916186,0.018103177,0.030200511,-0.017678365,-0.03773809,-0.004723532,-0.016606953,-0.07269498,0.012315615,0.010133174,0.030442186,0.019813081,0.06670097,-0.07942071,0.008212355,0.014193114,0.06321758,-0.05563816,-0.0137206,-0.11957818,-0.015415892,0.025415787,-0.011048563,0.035021424,0.05738457,0.025340416,0.024557767,0.01829559,-0.028381774,-0.044773195,-0.0009059987,-0.009635102,-0.011407561,-0.07953243,0.04201477,-0.06982931,0.036012262,0.055681143,-0.051384933,-0.036876258,0.031578474,-0.017779343,0.030029928,0.04383134,0.0050203353,0.06199274,-0.033747017,0.041793056,-0.03380824,0.04045138,-0.059986655,-0.092115745,-0.040505655,-0.05539737,-0.09043104,-0.057957906,-0.04214637,0.0028020279,0.026249353,0.15822734,0.008776663 +2.1.1.161,"This enzyme, from the marine cyanobacterium Synechococcus sp. WH8102, differs from EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase in that it cannot use sarcosine as an alternative substrate [1]. Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular 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+2.1.1.162,"Unlike EC 2.1.1.156 (glycine/sarcosine N-methyltransferase), EC 2.1.1.157 (sarcosine/dimethylglycine N-methyltransferase) and EC 2.1.1.161 (dimethylglycine N-methyltransferase), this enzyme, from the halophilic methanoarchaeon Methanohalophilus portucalensis, can methylate glycine and all of its intermediates to form the compatible solute betaine 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+2.3.1.183,"The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2, glutamine synthetase, a key enzyme of nitrogen metabolism in plants 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+2.3.1.184,"Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates [1]. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA [1]. S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone 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+3.1.1.81,"Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria [5]. N-(3-Oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L-homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates 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+3.5.1.97,"Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine lactone ring of AHL-dependent quorum-sensing signal molecules. It has broad specificity for AHLs with side changes ranging in length from 11 to 14 carbons. Substituents at the 3'-position, as found in N-(3-oxododecanoyl)-L-homoserine lactone, do not affect this activity.",384,1.0,-0.0964549,-0.049312312,-0.041350488,0.041677196,0.009440173,0.08394436,-0.07139603,0.06853612,0.06799486,-0.027622072,0.045279693,-0.026521973,-0.014773983,0.025721788,0.01990896,0.059259478,-0.036079545,0.07919186,-0.055111527,-0.053189896,-0.014012978,0.07190069,-0.045110963,-0.016575336,-0.043119516,-0.059529606,-0.036619976,-0.005045584,-0.01609029,-0.051469628,-0.0028482913,-0.048195444,0.088998936,-0.017519815,0.01613156,0.033086374,0.029709635,-0.15480839,0.11099622,-0.009376984,0.041532014,0.042370994,0.030904561,-0.019866077,-0.010008506,0.0152860265,-0.016147016,0.063111335,0.019784817,-0.035806023,-0.098244555,-0.034829624,-0.00096454495,0.049924944,0.0395914,0.032442816,-0.010034198,-0.035726573,0.023287725,-0.041470475,-0.0066656535,-0.046296295,0.055979315,-0.03303059,-0.06285296,-0.077308804,-0.017781204,-0.081909545,0.0818141,0.016751666,-0.04602808,-0.076779075,-0.015383337,-0.02977973,0.022378473,0.10694783,-0.0668112,-0.096597396,0.020161636,-0.036253933,0.040460657,-0.049528204,0.06326874,0.07437829,0.03279676,-0.066079006,0.09483414,-0.028532738,0.026534248,0.020338787,-0.0053393305,-0.02254146,-0.009346835,0.010029723,-0.14836656,-0.008632764,0.03950981,0.049549207,-0.047754474,-0.01321386,-0.07499311,-0.049717557,-0.031299233,-0.05660885,-0.07069897,0.01547205,0.015103255,0.018167716,0.014786276,0.0644527,-0.010129635,-0.021363884,-0.03500769,-0.0025284325,-0.0069505074,0.08363292,0.07737942,0.017802373,-0.05501809,0.015624731,-0.014140126,-0.050729096,0.031100376,0.001966219,0.0152582815,0.07514055,-0.05522084,9.848687e-34,0.00090822886,0.015648346,-0.0430251,-0.04619506,0.045527883,-0.09947121,-0.11390258,-0.0050699273,0.012418424,-0.038088765,0.03870947,-0.03701567,0.022500977,0.037534095,0.03530448,-0.07302717,-0.043199994,-0.067060076,0.016418016,-0.0025091232,-0.0002792872,0.008180551,0.03899614,0.05464168,0.06646001,-0.03991773,0.06420272,0.033577476,-0.0029359127,-0.011059166,0.049696278,-0.06596738,-0.09119347,-0.024128342,0.08271752,0.06502229,-0.017585143,-0.010726507,-0.06557456,0.026625916,-0.014732759,0.008638098,-0.029585592,-0.03767164,0.081195936,-0.0004135138,-0.08944507,0.06668337,-0.0064017954,-0.030106384,0.036293454,-0.031781435,0.0854727,0.05747575,0.010334557,-0.027305419,0.007048133,-0.009997941,0.02134208,-0.009040009,-0.024303515,-0.10072362,-0.0049676024,0.021112673,0.017472401,0.07460151,-0.04725024,-0.039152153,0.042745244,0.028094403,-0.00426637,-0.037655964,-0.008678295,0.039653633,-0.025717173,-0.019802457,-0.07971423,0.07875162,0.015137056,0.025740499,0.03286344,-0.030361403,0.01963793,0.04446502,-0.071024664,-0.081437826,-0.001253419,0.0085905865,0.013390515,-0.10620871,0.094921,0.017972032,0.040462837,0.04237953,-0.0028850352,-3.040767e-33,0.07003482,-0.08168155,0.022426674,-0.021245576,-0.056499284,0.034916863,0.04887059,0.042668536,0.012390832,-0.08095979,0.06174268,-0.0057332115,0.011986604,-0.016823333,-0.012223146,0.015858728,-0.007161836,-0.015581722,-0.046421286,-0.037835296,-0.010511087,0.023259629,-0.032025732,0.06730752,0.050472125,0.089700274,-0.052098367,0.07474616,0.013165553,0.049244016,-0.032949753,0.039735645,-0.0057895533,-0.103943944,-0.0043812385,0.07462648,-0.009258342,0.055358503,-0.044879913,0.029809607,0.02307263,0.036753096,0.03374144,0.06905031,0.027650598,0.09575314,0.012309229,0.0460683,-0.051591497,-0.04698605,0.033335965,0.022045072,-0.011261805,0.043174837,-0.00058550696,0.07860075,0.023520848,-0.015449784,0.004149097,-0.010657715,-0.0627012,-0.035199556,0.03517511,-0.024804987,-0.019168537,0.0103594,0.03519416,-0.059103295,0.073610745,-0.024283214,0.029443385,0.12085366,0.027115606,0.025967875,-0.052163374,0.0023061407,-0.108765244,-0.09860967,-0.078738876,0.01591099,-0.04700428,-0.075456515,-0.03134897,-0.006914524,0.08803605,-0.07618322,-0.023028882,0.015833441,-0.0017598366,0.04543594,-0.05867622,-0.06587404,-0.006309368,0.06421568,0.05987419,-5.224492e-08,0.030747287,-0.049172703,0.015268638,-0.038546894,0.013784752,-0.018455772,-0.07892058,0.01932399,0.13901444,-0.07290352,-0.026076784,0.13041186,-0.009426637,0.0881556,0.016189655,-0.02129343,-0.0027361028,-0.042913917,-0.02144663,-0.0472063,-0.10697901,-0.061518744,-0.115375064,0.020617034,0.030761084,-0.0559346,0.0015161257,0.03259802,-0.047935385,-0.08154005,0.048512436,0.0708855,0.08783407,0.0009772299,-0.02619526,0.037210405,-0.0013505921,-0.099317156,-0.009669506,0.06819022,0.020696227,0.002093731,-0.11789849,-0.010124339,0.021450588,-0.038717188,0.04202954,0.037271082,-0.051481836,0.05824061,0.064913355,0.016502637,0.007721878,0.0050355424,-0.06845124,0.013077487,0.020006288,-0.018083852,0.005097959,0.07798602,0.009448485,-0.07872588,0.15406813,-0.056499634 +4.2.1.113,"Belongs to the enolase superfamily and requires divalent cations, preferably Mg2+ or Mn2+, for activity. Forms part of the vitamin-K-biosynthesis pathway. ",384,1.0,-0.031966288,-0.051187865,-0.099326596,0.0072661173,0.016512219,-0.023725633,-0.017419929,-0.022654872,-0.03972345,0.027627833,0.052560918,-0.09329398,-0.006546429,0.016129408,-0.00014306944,0.0031112544,-0.043989945,0.058091976,-0.024952106,0.006477478,0.092642166,0.03645413,0.00029878228,0.04229921,0.022538792,0.028591702,0.052460764,-0.019150358,0.013972439,-0.0104015,-0.079770625,0.028349292,0.07870178,-0.06780034,0.06450929,0.084747754,-0.052631825,-0.01320655,0.015486694,-0.11539256,0.025329363,-0.023748636,0.040813737,-0.019047718,0.00016805252,-0.038282868,0.056307685,-0.042490333,0.01932795,0.024030227,-0.03455069,-0.057129323,-0.08005871,0.06511733,0.048062436,0.008446161,-0.09426036,-0.020002723,-0.01730992,0.043084133,0.04113752,-0.07648155,-0.0055959853,0.0171397,0.009188302,-0.021030383,0.04821959,0.0020701995,-0.020894788,-0.066083714,0.065605626,-0.079358995,-0.017669214,0.06081848,-0.05257689,0.12861313,0.08314525,-0.020116407,-0.0022324512,-0.04128743,0.043412544,0.05326703,0.06919476,0.07530906,0.07341082,0.020528054,0.02184289,-0.0018283677,0.023558725,0.07534277,0.002246205,0.0030122085,0.08905149,-0.02592129,-0.012864644,0.045540165,-0.050471965,0.011661798,-0.02017313,0.010571011,-0.044333126,0.08055814,-0.026481435,0.0111628985,-0.013510629,-0.025526417,0.040741377,0.068106264,-0.0337283,0.026171379,0.01820005,-0.04411467,0.0130211795,0.07447288,0.039345197,0.040130984,0.0213813,-0.06106898,-0.0019099291,0.020584622,0.04504726,0.027678832,-0.0056824996,0.03916377,-0.105560884,0.024472842,-0.050152373,7.951091e-34,0.043185987,0.02918815,0.06404035,0.021844493,-0.00019877429,0.00511714,-0.07933603,-0.029984042,-0.0045715137,-0.09332938,-0.13277073,-0.044500995,0.056067154,0.037616145,-0.06814572,-0.009955825,-0.03868564,-0.00059207674,0.07580957,0.04072238,-0.032619763,0.06420717,-0.051457882,-0.038611867,-0.055563107,0.040677074,0.0051419595,-0.03502549,0.022661414,-0.012518455,0.073234,-0.124089286,-0.074042715,0.018341962,0.027019015,-0.056778025,-0.0028240816,-0.01300749,-0.024961235,0.06279411,-0.006598368,0.065877266,-0.08011004,0.03513018,0.02106343,-0.052888315,0.04157192,0.043423556,-0.00018204103,0.007767954,0.039493304,0.06169371,0.035399634,-0.070071094,-0.0546879,-0.0038823881,0.064782836,0.02133714,0.0013670208,0.018220663,-0.046626747,0.0027393552,0.054915007,0.030174509,0.060768817,0.0011245344,-0.14781113,-0.07464783,-0.068316676,-0.054150324,-0.012337782,-0.022112457,0.09628591,-0.0021995849,0.00013945653,-0.04206477,-0.051997498,-0.029123371,-0.07720758,0.0072670896,-0.022790188,-0.019736895,-0.025271147,0.020953475,-0.050545152,-0.03825823,-0.0037468406,-0.054773975,-0.0031596343,-0.015094726,-0.0053572254,0.035680115,-0.06543638,0.04439745,0.039054766,-2.2320112e-33,0.06629048,-0.025483655,0.058327895,-0.061655775,-0.061748575,0.095658354,0.012190522,-0.06185565,0.08775965,0.0765848,0.058798682,0.010842003,0.06632186,-0.10214155,0.00065670506,0.002582159,-0.029698495,0.11581398,-0.005459425,-0.11989598,-0.012274918,0.061284132,-0.011907517,0.036761463,0.060333863,0.11033101,-0.00532225,0.033040866,-0.053768948,0.049926322,-0.013125425,-0.04068407,-0.055026222,-0.029816119,-0.039915748,0.07273276,-0.012508961,-0.08800383,-0.044700913,0.012294451,-0.08618801,0.05559656,0.10970259,0.09618469,-0.015041415,-0.041313335,0.026390549,0.0647464,0.006702617,-0.054138392,0.07438293,0.016623305,-0.09363351,-0.005942583,0.060920697,0.034289055,-0.020273319,0.07534843,-0.0043473216,-0.06449716,0.014597282,-0.044268288,0.02965851,-0.02654871,0.036819518,0.015295883,-0.027390163,0.028053576,0.00526632,0.030988922,0.04273741,0.013203907,0.024392357,-0.022598745,0.012464721,0.027721394,-0.030685758,-0.11372542,-0.017882144,-0.0851418,-0.05702393,-0.013565468,-0.022147816,0.012215735,-0.01922425,-0.10019845,0.032380853,0.0816696,0.016990418,0.005737296,-0.042929683,-0.07704949,-0.0958869,0.08479944,0.06571473,-3.047718e-08,0.063153364,-0.063955404,-0.026164444,-0.0072321296,-0.0027937496,0.021873165,-0.043058585,0.016646435,0.12028559,-0.014749996,0.0643505,0.018304147,0.041128274,0.05646135,0.055287167,-0.030702509,0.02528817,0.05749236,-0.075339824,-0.016195243,-0.008800449,-0.07129646,-0.067875594,-0.033213478,0.00051154505,-0.10387346,-0.05091203,0.045718547,-0.00075496454,-0.027995385,0.046438232,-0.045157332,0.014317732,-0.052313827,-0.02866995,0.09573871,-0.021155618,-0.028494565,-0.024416618,-0.022000995,-0.076424584,-0.100867234,0.029353742,0.06537953,-0.057605296,0.032268286,0.028875692,0.10743338,-0.044151176,-0.0038924543,-0.03042437,-0.060523596,-0.0032192043,-0.07489819,-0.106925234,0.026557123,0.0006428878,0.002144583,0.08654279,-0.04960255,-0.027578905,0.055628672,0.077359326,-0.02995527 +4.2.2.22,"Differs in specificity from EC 4.2.2.9, pectate disaccharide-lyase, as the predominant action is removal of a trisaccharide rather than a disaccharide from the reducing end. Disaccharides and tetrasaccharides may also be removed [2]. ",384,0.99999994,-0.00632454,0.0005927353,0.05916591,-0.022811746,0.07710306,0.015603016,0.0045198775,0.005200813,0.0483561,0.007915265,0.10998485,-0.04871412,-0.071413875,-0.039165024,0.021309072,-0.07286085,0.03564606,-0.04929032,-0.008101427,-0.044171147,0.062213153,-0.03895187,-0.0738903,0.024328958,0.044775244,-0.035845052,-0.0059700054,0.027808668,0.016335038,-0.111700766,0.016028158,0.024699708,0.077848926,-0.062057238,-0.08202918,0.06421173,-0.0016054497,-0.06619217,0.023571184,-0.01566989,0.028825141,-0.000107390966,0.00464804,-0.06136996,-0.01535429,0.030379387,-0.014500639,-0.029831542,-0.049683794,-0.083400495,0.032860905,-0.048938096,-0.055245563,0.084510826,0.03840002,-0.026327005,-0.051683344,-0.001914425,0.022779731,0.057101063,0.024612227,0.082665384,-0.042065877,0.027288573,-0.058470964,-0.02928081,0.0975612,-0.11363062,-0.030926367,0.068315156,-0.060043775,0.021015983,0.04777446,-0.016361339,0.04575177,0.052387558,-0.015740216,-0.09027606,-0.048934013,-0.025271539,0.018602239,0.041818503,0.0147178015,-0.03387788,-0.07337323,-0.093391195,-0.027000135,-0.09070863,0.024121564,-0.057783,0.092541076,0.023563407,0.05796866,0.06430925,-0.047934286,-0.02329127,-0.006157975,0.05585044,0.053490225,0.0040424564,-0.025062667,0.055193987,-0.037704438,-0.109003045,-0.03859146,0.04809344,0.035847083,0.03165935,0.04387262,0.04388772,-0.034982163,-0.031265,-0.040286414,0.022260321,-0.107805215,0.036913224,0.07810616,-0.079560764,0.020697493,0.05444361,0.026896581,-0.046070877,0.10683057,0.033132203,-0.06522351,0.035221595,-0.04053689,5.1984522e-33,-0.0160448,-0.058462128,0.030738518,-0.03329306,0.09692738,-0.0038668828,-0.089942664,-0.0068300893,0.04769316,-0.051639576,-0.08859041,-0.009485915,-0.02714147,0.1251898,-0.021699866,-0.047872633,0.0060967715,-0.039621945,0.023188336,0.017076397,0.03958742,0.08464339,-0.023695972,-0.012213836,0.075466745,0.0343139,0.013814599,-0.010227474,0.021493826,0.013398625,0.01136434,-0.06461031,-0.0702862,0.0005302844,0.01580045,0.05166444,-0.016371218,-0.010440367,0.009128822,-0.06342424,0.04807681,0.07993342,0.010118473,-0.03747544,0.057935577,-0.05865561,0.03410036,0.04535215,-0.0039006593,0.061900467,0.07532073,-0.03162148,0.035805516,0.0027326364,-0.061111223,-0.02821019,-0.018831914,0.01293206,0.0053780535,0.07295394,0.040053636,0.090559304,0.006804048,-0.04743864,0.011858465,0.040139195,-0.082946114,-0.039086275,-0.061755244,-0.057973843,-0.118867084,-0.022335552,0.08210543,0.0050256057,0.04793149,-0.0974269,-0.057812855,0.0009972646,-0.010653185,0.0062385728,-0.017100839,0.005649327,0.03794299,0.02201531,-0.03625129,0.006725924,-0.008828355,0.048319124,0.08283531,0.034468964,0.007728051,0.014099448,-0.042971298,0.07264254,0.036204305,-6.523544e-33,0.032327496,-0.002854357,0.018888917,0.010920487,-0.043185204,0.03295729,0.04553803,0.044659067,0.037658945,-0.05671253,0.060518492,-0.03692105,0.027041245,-0.071344055,0.03222794,0.018531347,-0.10579676,0.017929113,-0.13369161,0.011541781,-0.08080151,0.04312151,0.0631025,-0.03502842,0.08728955,0.003966223,0.048353385,0.05248447,0.0395483,-0.037434954,-0.05917964,-0.05487439,-0.10902552,-0.034932744,-0.11509049,-0.093031555,-0.06340427,0.006955328,0.006244624,0.008103018,0.019730683,0.026163524,-0.007380927,0.0564353,-0.03840821,0.0991184,0.018378677,0.06484549,0.040217638,-0.007567901,0.010742263,-0.02598213,-0.030087821,0.028957985,0.023020782,0.041598387,0.077487394,0.014076234,-0.050352197,-0.039222326,-0.061983623,0.014785135,0.06811138,-0.042632733,0.120007075,-0.011212195,-0.06520404,0.07244207,0.07787242,-0.009922727,0.013896304,-0.00922225,-0.11131626,-0.11163454,0.002662932,0.05384334,-0.10104923,-0.091019124,-0.027334645,-0.016601516,0.027561333,-0.016265778,0.016064072,-0.08294635,0.019230753,-0.045436785,-0.024372408,0.032882188,-0.010347273,0.040933512,0.026808051,-0.022344379,0.049641304,0.11586907,0.05382499,-4.0813834e-08,0.033511948,-0.022539964,-0.04301535,-0.007687262,-0.02025029,-0.054860964,0.011632786,0.1052643,-0.020876603,0.00057702453,0.027895302,0.08412134,-0.04129754,0.04597408,0.053074803,0.0108985165,0.0012475433,0.050399754,-0.011573972,0.027199265,-0.108300075,-0.07961109,-0.10774399,0.040383823,0.0022070582,-0.0036051562,0.07123143,0.04015928,-0.061953805,-0.0052632685,0.056497056,0.070133775,-0.048945367,-0.03361072,0.021708414,0.02273081,-0.06287714,0.027999109,-0.086361825,0.010405974,0.04166211,0.00011631521,-0.07531327,0.02677755,-0.0132359145,-0.0021304053,0.013855306,0.07354356,0.0049620783,0.014834001,0.02693496,-0.028245255,-0.047926635,-0.04114176,-0.05664227,-0.016989034,-0.014528453,-0.032613922,0.03571799,-0.040692512,0.04602511,-0.042471964,0.10253439,0.006699298 +5.1.1.18,"A pyridoxal-phosphate protein that is highly selective for L-serine as substrate. D-Serine is found in type-II astrocytes in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate (NMDA) receptors [1,2]. The reaction can also occur in the reverse direction but does so more slowly at physiological serine concentrations [4].",384,1.0,-0.005525929,-0.09043918,-0.048833363,-0.06128372,0.032427855,0.049799778,0.009640647,0.006741655,0.07692849,0.03907579,-0.020197865,0.10888223,-0.06993717,0.057342004,0.0038477047,0.014763378,-0.014915551,0.013534395,0.04085735,0.02881851,0.01382845,0.056874227,0.05390565,-0.032516718,-0.06783747,0.07081155,0.041705463,-0.006655083,0.00705168,-0.018364592,0.049126964,0.011068,-0.06546155,-0.0060646944,0.02795466,-0.033336904,-0.08364778,0.026893927,-0.028090801,-0.043844342,0.06709081,-0.045265257,-0.015785662,0.0056464896,-0.03617791,-0.037639704,-0.0072340667,-0.04324767,0.04076998,-0.039563067,-0.0024541756,-0.06848542,-0.030081425,0.034746774,-0.03231871,0.028632807,-0.084564865,0.042169116,0.013999522,-0.043520343,-0.0165379,0.07179708,0.03799992,-0.058956932,0.13489154,-0.039538883,0.0075212284,-0.11607226,0.00062239583,-0.06618475,-0.028293552,-0.06429178,0.06085015,0.0009648749,-0.021816503,0.052328613,-0.038710486,0.006076626,0.052165616,-0.04406885,0.039830383,0.04317451,0.0044959234,0.12519501,0.07787871,-0.003933464,-0.026689012,0.12922677,0.06142514,0.00059064967,-0.023704171,-0.074661314,-0.07607032,0.04019007,-0.08317955,-0.02907988,0.009655705,0.06522549,-0.0137474835,-0.00047628462,-0.0027679563,0.10247751,-0.059819497,-0.007205646,-0.067147754,0.024016574,0.008289191,0.01981047,-0.07937643,-0.07614631,-0.07825694,0.018008135,-0.028200552,0.07864071,-0.012633483,-0.0033020542,0.03602627,0.04414254,-0.0026507834,-0.07681726,0.026158016,0.012265916,0.045400027,0.041601725,0.038140062,0.1002208,-0.123777196,-2.5775896e-34,0.08107696,0.0038400688,0.06656566,-0.046176292,-0.030510306,-0.03910605,-0.042543784,-0.0037326417,0.010038242,-0.030404294,-0.07545216,-0.0467732,0.04966526,0.0647443,-0.034052927,-0.041065965,-0.041954592,-0.019066991,0.10511339,-0.122420125,0.03204175,0.088764064,0.03280918,0.04599338,-0.005114368,-0.009468327,-0.067655005,0.06516355,0.079976074,0.0383318,-0.043869816,-0.14498384,-0.04075186,-0.013855799,0.007776085,0.016864562,-0.055160034,-0.040792175,-0.008857591,-0.002335044,0.052549805,-0.045647945,-0.017420033,0.035631537,-0.04951275,-0.032841846,-0.03421436,0.036702387,-0.010860216,-0.010614732,0.022550538,-0.114994675,-0.00057422783,-0.06741818,-0.10273713,-0.0050590388,-0.043284178,-0.011786663,0.024947014,0.09776401,0.0035361773,-0.034461096,0.00048940035,0.05542449,0.08461054,-0.013067242,-0.050157133,-0.044875465,-0.02466878,0.03214731,-0.00024807834,-0.01671796,0.13090858,-0.00540214,0.0051613874,-0.06554202,0.030554507,0.047277752,-0.010476747,-0.009370198,0.014169619,-0.042373884,-0.08780587,0.038227502,0.0073036924,0.011065,0.042150386,-0.12921344,-0.055491406,-0.022294575,-0.011273468,-0.03119962,0.006372897,-0.03870415,0.0077316947,-2.0166776e-33,-0.06389641,-0.056961875,0.10595299,-0.04049891,-0.028056806,0.043957178,0.07957377,-0.042713545,0.025030162,-0.013999547,0.0030672422,-0.027815815,0.0304073,-0.05567788,-0.041495755,-0.026153918,-0.046396255,0.0016356227,0.08141839,-0.043557256,0.011919174,0.06838548,-0.0027080001,0.09938056,0.056116425,0.009094122,0.013740639,0.05728685,-0.07623801,0.090660445,0.037476294,0.10314441,-0.06606408,-0.07032798,-0.038082946,0.061405946,-0.043749314,-0.04219232,-0.0538124,0.0120199695,-0.06175985,0.04730333,0.07039765,0.044611264,0.042475414,0.030137924,0.0077002854,0.022093365,0.020146202,-0.0022363479,-0.008856402,0.014138512,0.0025642095,-0.041309964,0.02355635,0.08543491,0.00058223197,0.017359005,0.024504676,0.016004317,0.020206632,-0.055558015,-0.03533652,0.012612752,0.083305225,-0.023908569,0.058920503,0.05376197,0.07044295,0.022640921,0.059869964,0.034812335,0.033245187,0.10140843,-0.0010178523,-0.06643397,-0.034927446,0.06112684,0.05227519,0.013039816,-0.039578017,0.015395595,-0.028173469,-0.051279504,0.01108233,-0.020285236,-0.017032703,0.12269373,-0.03142268,-0.01091332,-0.030709676,-0.037370823,-0.07570477,0.038555156,-0.0019479496,-3.937314e-08,0.09084746,-0.11079464,0.012275755,-0.030478027,-0.020198932,0.0038091836,0.0067746225,0.039671544,0.003582804,-0.039436493,0.029836267,-0.0230847,0.021199342,-0.026281714,-0.009324254,0.08829325,-0.034544647,0.06893948,-0.032584686,-0.06636601,0.008967633,0.029515818,-0.043320876,-0.0071712034,0.06209,-0.01524576,0.00476692,0.062776566,-0.071776405,-0.06405536,0.04610714,-0.020154351,0.04774205,-0.113007545,-0.008437182,0.0022857673,0.02929176,-0.014271805,0.014253758,0.05062089,-0.039362807,-0.0024537793,-0.0126900505,0.016291609,0.0015456897,0.0705069,0.0007316977,0.07372583,-0.06024106,-0.021562114,-0.0016657694,0.009356642,-0.030077428,-0.08625996,-0.12464686,0.048439644,-0.07557702,-0.044699863,0.034250043,-0.14811485,-0.012630322,0.058444805,0.037044823,-0.017257782 +4.1.2.42,"A pyridoxal-phosphate protein that is activated by divalent metal cations (e.g. Co2+, Ni2+, Mn2+ or Mg2+) [1,2]. The reaction is reversible, which can lead to the interconversion of D-threonine and D-allo-threonine [1]. Several other D-beta-hydroxy-alpha-amino acids, such as D-beta-phenylserine, D-beta-hydroxy-alpha-aminovaleric acid and D-beta-3,4-dihydroxyphenylserine, can also act as substrate [1].",384,1.0,-0.04066124,-0.14594635,-0.008121246,-0.05115785,0.051359933,0.038726266,0.023316834,0.04543211,0.014101601,0.072800726,-0.011349143,0.04404821,-0.050988246,0.08207879,-0.004121567,-0.023181386,-0.022948856,0.04794422,0.017324217,0.025974398,0.020466117,0.02427221,-0.021068688,-0.03321232,0.03274024,0.13288577,0.06511265,0.03449259,0.014734165,-0.011266376,-0.03905854,-0.016834483,-0.012529419,-0.021197246,0.024425128,0.08015754,-0.10050753,0.03210465,0.0072498675,-0.032480076,0.05692041,-0.063636586,0.032642465,-0.02144413,-0.058287892,-0.028892884,0.011428379,0.0639855,0.01058249,-0.0068400023,-0.012184827,-0.03063563,0.010937443,0.007164889,-0.0137100965,0.045852873,0.023267219,0.042768303,-0.01730651,-0.049460582,-0.005011566,-0.027497312,0.03053358,-0.0039664824,0.057090584,-0.0021276863,-0.030314112,-0.016003031,0.046630304,-0.051403936,0.0016456412,-0.0018609002,0.06772336,-0.0007318245,0.024388116,0.06231938,0.013055366,-0.05670853,0.01914401,-0.027231872,0.049343374,0.036174357,0.100999326,0.07230444,0.06720448,0.048029695,-0.03221628,0.022048231,0.032387834,0.0010537647,0.011662981,0.07001447,-0.0057192156,-0.0079621775,-0.06907928,0.022318896,-0.03715917,-0.011829521,-0.016853258,0.009208249,-0.02491865,0.06678054,-0.08828585,-0.04564062,-0.07220911,0.0117767425,-0.035105143,0.022641012,-0.05518686,-0.04025713,-0.03922132,-0.0016697265,0.036976192,0.08381367,-0.053681877,0.012270857,0.08307621,-0.041380573,-0.03162848,-0.10568194,-0.015987879,-0.0315651,0.033397313,0.111848146,-0.05111449,0.007782651,-0.026000768,2.4997497e-33,0.05841856,0.07669628,0.01311036,0.0005308104,0.006098163,-0.03060258,-0.080112636,-0.025176305,0.008447732,-0.048354246,-0.04511923,-0.017015252,0.061253093,0.009334334,-0.035017904,-0.051861364,-0.04655706,0.106739946,0.14920714,-0.064534724,0.019079588,0.0762073,-0.025942298,0.07442884,0.030551396,0.05949645,-0.030491559,0.09981064,0.036736663,-0.035637066,-0.008001261,-0.07674735,-0.023900948,-0.002783233,0.008572368,-0.043151524,-0.1478181,-0.030424537,-0.037491288,0.037270814,-0.026500784,-0.047421962,-0.083594315,0.028058982,0.031680208,-0.11533874,-0.034472223,0.05860485,-0.089722164,0.0003109819,0.07619176,-0.04294458,0.04545947,-0.09886112,-0.14379421,-0.012600763,-0.050674725,-0.07233397,0.07036766,0.09269167,0.0134833455,0.0028886204,-0.018153505,0.04478723,0.039306823,-0.028163407,-0.0043595727,-0.10042032,-0.00905678,0.065515675,0.03578892,-0.02325109,0.068651445,-0.0067997244,-0.0021771165,-0.034819756,-0.07408454,0.019687913,0.042560503,-0.006778114,0.021394305,-0.012917589,-0.034860887,-0.018054094,-0.025402406,-0.019731317,-0.010395088,-0.13890037,0.0028718838,0.022911875,-0.014467623,-0.08818009,-0.051756766,-0.013690235,0.047479436,-3.8238126e-33,0.037441853,-0.06728132,0.020847732,-0.024077753,-0.07517229,0.03615693,0.045180846,2.2543773e-05,0.07055641,-0.047379386,0.06019547,-0.050458092,-0.039130352,-0.055910643,-0.053039078,0.030080406,-0.014376389,0.008267601,0.02550827,-0.014453278,0.033649664,0.036790844,0.034536403,0.09808586,0.07193437,0.021697698,0.039394233,0.050287835,0.050274856,0.13700509,0.0536666,0.047844782,0.03238212,-0.043682616,-0.033793904,0.1064136,-0.05542074,-0.013406171,0.0034671393,0.025257172,0.0021203752,-0.0005951863,0.040420443,0.063472174,0.013842652,0.03909608,-0.03374234,-0.0049358937,-0.05488494,-0.06481881,0.023048619,0.016854491,0.012839022,-0.019050334,0.0324057,0.0894887,0.021958366,0.009388201,0.012447639,-0.03496388,0.04162553,-0.111149006,0.0044528083,-0.0067188046,0.048558153,0.0023652653,-0.015445515,0.046087664,0.061173853,-0.0014905226,0.08996456,0.020376196,0.024824793,0.074291736,-0.052731067,-0.06580906,0.0074485946,0.031930324,0.0104047,0.010329444,-0.05452139,0.017730035,-0.022512872,-0.036090195,0.018402902,-0.04612681,0.055751305,0.1164669,-0.026327645,0.04300196,-0.017214132,-0.016310737,-0.034066807,0.066049844,0.079094954,-5.6902973e-08,0.07862728,-0.0900387,-0.020297958,-0.042624023,-0.034117274,-0.03277801,0.073145635,-0.025071561,-0.00058417325,-0.06254371,-0.008532354,0.041243713,0.00026987313,-0.018468184,0.05744369,0.041566566,-0.08006501,-0.019624311,-0.066532895,-0.044761952,-0.03408698,0.004035511,-0.09948365,-0.026329633,0.0138018215,-0.043804552,0.029818742,-0.009875235,-0.0753931,-0.0101307295,0.06382768,-0.028927833,-0.040030014,-0.08969076,0.041164104,0.08275752,-0.02163035,-0.056755234,0.0049239607,-0.05426616,-0.113353305,0.021631822,-0.015047254,0.07456448,-0.0043188143,0.021491172,-0.071368895,0.0683876,-0.024514252,-0.04306145,0.027862886,-0.0046093552,-0.042459738,-0.15227556,-0.12385145,0.09099093,-0.012156445,-0.029813295,-0.024446687,-0.05378046,0.015350358,-0.026667895,0.106351376,-0.06753349 +1.1.1.294,"This enzyme carries out the first step in the conversion of chlorophyll b to chlorophyll a. It is involved in chlorophyll degradation, which occurs during leaf senescence [3] and it also forms part of the chlorophyll cycle, which interconverts chlorophyll a and b in response to changing light conditions [4,5].",384,0.99999994,-0.05932505,0.006736659,-0.07405819,-0.014837826,0.107810475,0.04043298,-0.024171209,-0.03548587,0.011728536,-0.0042416602,0.042738866,-0.06108395,0.001725347,-0.015588302,-0.00046636962,0.14184153,-0.20035516,0.024504809,-0.102830924,-0.07833661,0.036434025,0.0051226807,-0.08782293,-0.023044629,0.053174753,-0.04752414,-0.048698977,-0.043743707,0.029721962,-0.070157096,-0.038079485,0.06740833,0.011839001,0.0032854693,0.03709821,0.082127325,0.023151565,-0.14084247,0.010960441,0.0018021535,0.015262894,0.024573041,-0.089946866,-0.023681782,-0.0549838,0.040187486,0.007806584,0.009358365,-0.022120904,-0.058410436,0.0017539114,-0.04777707,-0.07667384,-0.010391398,-0.026912939,0.06713536,0.019888127,0.0039327466,0.02263661,0.021462362,0.003938726,0.024256404,-0.028259503,0.021749524,0.036215946,-0.031333476,0.023493305,-0.11451844,0.011761354,-0.06616775,-0.12613669,-0.07714184,-0.026495626,0.005361016,9.8184624e-05,-0.046571963,-0.021836333,-0.0072504412,-0.039550677,-0.028470362,0.014599977,0.031141954,-0.031013647,0.079194374,0.041071262,0.0025681253,-0.04026289,-0.032692663,0.008623422,0.033347826,-0.013495402,-0.014150465,-0.06010526,-0.0045479545,-0.06345859,0.113135085,0.02460781,-0.08272387,0.037253164,-0.02570975,-0.03704304,0.009253184,-0.08395906,-0.09277227,-0.10220562,0.011560537,-0.030471839,0.047352947,0.01698478,0.00317087,0.026590867,0.047917917,0.040126804,0.026548106,0.019249698,0.05791026,0.031084998,-0.004554112,-0.018418314,0.052876167,0.015617269,0.006393989,-0.021861807,0.048830744,-0.05935788,0.069555596,-0.019356763,2.2444854e-33,0.03188311,-0.015166773,-0.03046885,0.02476266,-0.035672057,-0.017848922,-0.04893262,0.012955216,-0.078443736,-0.08529336,-0.018941902,-0.07904061,-0.0244819,-0.061078753,-0.034541365,-0.013687013,0.0014978423,0.04066791,0.015672918,-0.011567984,-0.0074874004,0.07261451,-0.09540849,0.02162834,0.019125083,0.055243507,0.044888657,0.032457735,0.07071232,-0.02839759,0.006396527,0.02066709,-0.101206176,0.013616767,0.044151016,0.01826963,0.037544608,0.015329381,-0.00025823206,0.11511048,-0.030406902,0.036255326,-0.008310211,0.009963157,0.07498096,-0.021107541,-0.034401327,0.06644858,0.081198044,0.053349826,-0.035174873,-0.026192337,0.06811483,-0.0091739455,-0.05880169,0.06512288,0.06295027,-0.06453668,-0.06000251,0.03394689,0.04397329,0.0076564355,-0.05317711,0.025782008,0.0074552544,0.037624534,-0.045925286,-0.0709358,-0.02853913,0.009545845,-0.10288811,-0.042926434,0.01536992,0.052381836,0.09288249,-0.038432203,-0.027799668,0.030798908,0.012816217,-0.033088624,-0.022917178,0.029494956,0.06215907,-0.119380206,-0.041392587,-0.06562267,0.00433132,-0.10416309,-0.020599563,-0.033672392,0.09982788,-0.05965207,0.03800422,0.013488816,0.04997307,-4.1489547e-33,0.0617035,-0.08414927,0.04676738,-0.023420213,-0.01891195,-0.0017525682,-0.053316448,-0.082049094,-0.029017381,0.07651651,0.03311523,0.0425129,-0.0459567,0.019010244,-0.0018740153,-0.03289536,0.109636076,0.07940934,-0.057669878,0.010597053,-0.017570809,0.07221438,0.071222536,-0.03950582,0.019649534,-0.004475943,-0.0197168,0.10694714,0.08828017,-0.019711915,-0.06896681,-0.051402688,0.014437061,0.030540094,-0.014147922,0.007253994,-0.04797208,-0.021436976,0.018050034,0.06578342,-0.002152421,-0.00088709523,0.025861906,-0.026974717,0.023112806,0.03423021,-0.071338445,0.015071728,0.029863391,-0.088081166,0.04288701,0.09497365,-0.015161298,0.026539579,-0.009778214,0.050154854,0.038944658,0.03137902,-0.0122541,-0.049256727,-0.04403019,-0.06467963,0.060280304,0.040031206,0.029343722,0.058211673,0.03133309,0.088452704,0.038928032,0.015954815,0.072486944,0.079358995,0.053044725,0.038370296,-0.048138443,-0.0877483,-0.0074930913,-0.061957654,-0.054519344,-0.067332156,-0.06961847,0.011409109,-0.029714933,-0.028138934,-0.04992699,-0.110697895,0.0090282485,0.0498462,0.019743819,-0.0067276764,0.0015645005,0.019550342,-0.020288505,0.040495627,0.09485613,-3.8065956e-08,-0.03088781,-0.009967124,-0.019968703,-0.036334366,0.02287054,0.042983595,0.0029698026,-0.007623212,0.12046197,-0.015793221,-0.075414084,0.06615026,0.07389384,-7.2696625e-05,0.017084975,0.04983495,-0.012036049,-0.04196615,0.055978548,0.044257592,-0.09302563,-0.04453815,-0.072799675,0.059164714,0.024166003,-0.024534822,0.01415449,0.12076849,0.04693112,-0.0023664993,-0.006234332,0.052625235,0.0047609904,0.005820819,-0.052265212,0.012699015,-0.0077893184,-0.01252447,-0.067596145,0.0936728,0.05001817,-0.0061333175,-0.09595179,0.025553823,0.0123912925,-0.012880882,0.027949108,-0.024656925,0.016591692,0.064048424,0.09867162,-0.032633625,0.002022833,-0.03243157,-0.10823644,-0.043689966,-0.01015393,-0.019005828,-0.020311287,0.032934655,-0.0038092532,0.07178779,0.106579594,0.03693327 +1.3.1.80,"Chlorophyll degradation is a characteristic symptom of leaf senescence and fruit ripening. The reaction catalysed by this enzyme requires reduced ferredoxin, which is generated either by NADPH through the pentose-phosphate pathway or by the action of photosystem I [1,2]. This reaction takes place without release of the substrate from EC 1.14.12.20, pheophorbide a oxygenase [3]. Depending on the plant species used as the source of enzyme, one of two possible C-1 epimers of primary fluorescent chlorophyll catabolite (pFCC), pFCC-1 or pFCC-2, is normally formed, with all genera or species within a family producing the same isomer [3,4]. After modification and export, pFCCs are eventually imported into the vacuole, where the acidic environment causes their non-enzymic conversion into colourless breakdown products called non-fluorescent chlorophyll catabolites (NCCs) [2].",384,0.99999994,-0.00931147,-0.05431604,-0.10295499,-0.01129697,0.18859583,0.047156967,-0.011610311,0.024027413,0.100951776,-0.010703753,0.039336033,-0.06665668,-0.07272003,-0.0069560604,-0.03768533,0.055494867,-0.13274199,-0.01942418,-0.023751331,-0.016331105,0.011892586,-0.031419326,-0.033112533,-0.006211377,-0.02799134,0.018290007,-0.0798572,-0.0023441948,-0.016276293,-0.056617327,-0.043496475,0.066341855,0.016517784,0.022164837,0.07597595,0.100605965,-0.016190743,-0.118018225,0.0043450594,-0.04175079,-0.013908661,-0.0011079861,-0.083146706,-0.013040601,-0.0583986,0.016118033,0.062065758,-0.015829489,-0.044324253,-0.080797285,0.03497181,-0.003466332,-0.037346143,-0.024068458,-0.0094733685,0.006509378,0.008214265,-0.0031350565,0.009278316,-0.019150281,-0.0675598,-0.029116867,-0.0068489974,0.0013572681,0.011260181,-0.0128015615,0.007744978,-0.09993888,0.059530985,-0.06920415,-0.15968664,-0.0126560945,-0.016053844,0.03116409,-0.0013476064,0.085021436,0.008681782,-0.001554147,-0.031096617,-0.022292037,0.035511162,0.05128586,-0.021015009,0.038959682,0.080158256,-0.018364007,0.002885603,-0.048440237,-0.018437043,0.023356736,0.048043035,0.07377563,0.02440266,0.06254101,-0.1092607,0.086432226,0.038003772,-0.054037485,0.024800004,-0.036358193,-0.03358674,0.045181297,-0.031943634,-0.08930314,-0.01935373,0.025699921,-0.054599904,0.06259179,0.022312084,0.016256223,-0.04072059,0.03812722,-0.021996656,-0.008025755,0.04647302,0.06651229,-0.0036721984,-0.033668257,-0.047981232,0.0141765345,-0.042048708,-0.06811601,-0.06803282,0.05560232,-0.07792098,0.011314167,-0.01742935,3.8511814e-33,0.036156856,0.023628527,0.012819352,0.020736016,-0.008632635,-0.014630248,-0.04117451,-0.038201027,0.003705995,-0.10690644,-0.013299393,-0.08212129,-0.04589223,-0.084391944,0.00058367767,-0.038096905,-0.0598392,-0.0070772734,0.032956216,0.05287989,-0.0035463353,0.056280922,-0.021062098,0.021045681,0.04731662,0.040104777,-0.035930965,0.013931458,0.03263393,-0.051299434,0.08044152,0.030799918,-0.060734164,0.002392591,-0.0046309954,-0.06202094,-0.0016821389,0.011915701,-0.004788991,0.08137143,-0.09041392,0.020605661,0.002863226,-0.015842203,0.09341089,-0.077688366,-0.057861283,0.110129595,-0.0018590199,0.026871458,-0.0030486935,-0.0019506483,0.05820903,0.042620525,-0.015703171,0.032670204,0.03316949,-0.12007906,-0.026610814,0.04802084,0.09239035,0.07812827,-0.011402578,0.037956223,0.01354541,0.038430564,-0.039836023,-0.003228188,-0.00155284,0.030223923,-0.04408474,-0.037220735,0.024817182,0.013958304,0.08850707,-0.075175375,0.0010782698,0.022605335,0.009397505,0.01802596,0.048869986,0.03994131,0.03132521,-0.07724177,-0.0919547,-0.03333818,-0.03276211,-0.04428736,-0.044007707,0.020473262,0.03729751,-0.050609697,0.04621446,0.0046229344,-0.046862498,-4.342809e-33,0.10101055,-0.09054644,0.008024198,-0.047179256,-0.04495009,0.039307855,-0.06368594,-0.02603768,-0.014812779,0.00023883715,0.035159938,0.060174763,-0.0027294788,0.037012912,-0.003228647,-0.006103511,0.0005495424,0.113121875,-0.047154494,0.0058390186,0.0051818267,0.07198375,0.013672433,0.030689228,0.029466016,0.03030248,-0.0025896437,0.006850371,0.08768246,-0.049746335,-0.041027896,0.001167728,-0.003267044,0.0439491,0.008326681,-0.05158481,-0.06288201,-0.017446747,0.02877525,0.12889542,-0.014985817,0.032884896,-0.025479816,-0.05258237,-0.03454315,0.0012898345,-0.084564425,0.018168332,0.020900588,-0.016004367,0.00017392234,0.08933364,-0.074165486,0.05806534,0.02907737,0.07117661,0.038406946,0.031445935,0.023992127,-0.02030853,-0.010360508,-0.018403081,0.016089993,0.027648166,0.078716256,0.031037966,0.03629972,0.12503038,0.012362102,0.055674393,0.096960045,0.07016494,0.022835283,-0.008973037,-0.0035008863,-0.029629517,-0.031222345,-0.0062427847,-0.019103162,-0.027135773,-0.013160288,-0.0055418224,0.025353394,-0.06798658,-0.03276812,-0.112921976,-0.005451061,0.009319382,0.05005479,0.01833102,0.045389872,-0.054209597,0.06561112,0.08154344,0.10790468,-4.5778446e-08,-0.05027283,0.0031846866,-0.015356616,-0.03608297,0.03946649,-0.031787824,0.04236882,-0.011450159,0.067997694,-0.051986303,-0.03643627,0.060267687,0.057162747,-0.044411507,0.04204304,0.07758538,0.024943616,-0.025178475,0.05913088,0.07551893,-0.13766333,-0.05970701,-0.12826964,0.0449558,0.019935925,-0.05072455,0.076867424,0.08171334,-0.016205817,0.024526231,0.05331594,0.027710963,0.07361597,-0.0758624,-0.007082381,0.04000682,-0.047253594,-0.08999772,-0.10467298,0.07810277,-0.058201846,-0.0028251512,-0.049100667,-0.030423911,0.04600897,0.03736976,0.048793886,0.0021163449,-0.005260347,0.05202367,0.049501054,0.0012403601,-0.028929865,-0.08851096,-0.10423478,0.020318689,0.03400695,0.036012728,0.013094276,-0.020286525,-0.020076066,-0.012460778,0.13442281,0.002757678 +1.14.12.20,"This enzyme catalyses a key reaction in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The enzyme from Arabidopsis contains a Rieske-type iron-sulfur cluster [2] and requires reduced ferredoxin, which is generated either by NADPH through the pentose-phosphate pathway or by the action of photosystem I [4]. While still attached to this enzyme, the product is rapidly converted into primary fluorescent chlorophyll catabolite by the action of EC 1.3.7.12, red chlorophyll catabolite reductase [2,6]. Pheophorbide b acts as an inhibitor. In 18O2 labelling experiments, only the aldehyde oxygen is labelled, suggesting that the other oxygen atom may originate from H2O [1].",384,1.0,-0.014864611,0.005486237,-0.11504771,0.012601708,0.18723671,0.08022158,-0.016873447,0.0101652,0.08338132,-0.016850885,0.04517852,-0.0015443254,-0.065054104,-0.041644987,-0.018866953,0.123888515,-0.12590349,0.022936184,-0.079076126,-0.058259107,0.063270874,0.0028985834,-0.03270757,-0.009100625,0.019881403,-0.0010429295,-0.029386034,-0.047205113,-0.05545855,-0.09785954,-0.017326232,0.035824344,0.045878395,0.021669978,0.01584451,0.1004321,0.027375158,-0.14716041,-0.0057227337,-0.010774411,-0.027248718,0.003634416,-0.065341905,-0.021317985,-0.099697486,-0.0023423624,0.03205065,-0.00057634426,-0.00486892,-0.03700549,-0.03500004,-0.027702052,0.00295189,-0.0041885884,-0.032965396,-0.0012051676,0.021103788,0.009122446,0.04267208,-0.033042554,-0.028851736,-0.057930227,0.007885059,-0.0015885277,-0.025544694,-0.0003355052,0.0012517504,-0.11196917,0.024468103,-0.09638452,-0.070023015,-0.0024929792,-0.026147489,0.0092844,-0.0014575731,0.06266244,0.015022998,0.027109478,-0.007088279,-0.0106438175,0.022943936,0.04320516,0.024541393,0.088953674,0.08942615,0.001286311,-0.042088103,-0.026510913,-0.019557519,0.013829754,0.020327646,0.036051575,-0.021264354,0.049792346,-0.106962785,0.11124348,0.010021658,-0.054522686,-0.00925416,-0.015872587,-0.033913534,0.08088453,-0.08806554,-0.080303125,-0.01826621,0.015407608,-0.045623936,0.06308669,0.0031433806,0.00034823085,0.013882782,-0.019944973,0.0112963645,0.030804284,0.033696845,0.07788951,0.031090435,-0.03723819,-0.06549493,-0.0015479435,0.017490275,-0.00396836,-0.04857647,0.053660836,-0.051244143,0.026622165,-0.1272223,6.110399e-33,0.08224481,0.033274725,-0.03459588,0.020899087,-0.027551873,-0.055104937,-0.09575217,0.029506275,-0.02118175,-0.10336239,-0.035782084,-0.069340326,0.010498298,-0.11401301,0.022083689,-0.07066368,-0.00650802,0.010942608,0.045084212,0.014731703,-0.017200828,-0.000658474,-0.05328461,0.005535741,-0.016080411,0.052850753,-0.032801747,-0.024066763,0.048710577,-0.0448523,0.076710306,-0.015828976,-0.0668025,0.03380953,-0.0031965778,-0.059141956,-0.03227013,0.007162609,-0.041159887,0.06019194,-0.078215696,0.07517142,-0.018003037,-0.008245849,0.13081276,-0.06269595,-0.063448116,0.09166769,0.067713134,0.08678921,-0.033403814,0.014166198,0.12214912,0.052810837,-0.059339114,0.02095871,0.0053236443,-0.06918441,-0.032729715,0.056064226,0.035572886,0.08448354,0.028020028,0.054625303,0.014996968,0.059175815,-0.013486894,-0.04128795,0.0007137777,0.10976609,-0.017567253,-0.022101028,0.0500374,0.061471526,0.060784824,-0.09032872,0.01377033,-0.020785278,0.016081352,0.01969211,0.047627453,-0.038516242,0.00067542616,-0.037207607,-0.08288566,-0.042087924,-0.02074484,-0.073128045,-0.014514449,0.028436614,0.04529799,-0.03457425,-0.014771691,-0.031144168,-0.030180803,-4.7022724e-33,0.081210315,-0.06553109,0.027051365,-0.053603433,-0.06398346,0.016713835,-0.041094646,-0.021752298,-0.014607961,-0.007595917,0.05141998,0.036437515,0.008082688,0.01609473,0.04786196,0.014034458,0.021656366,0.06663063,0.001616952,0.038986668,-0.019379133,0.102016,0.026493363,0.033658653,0.09161184,-0.009395262,0.026257126,0.05000203,0.087980695,-0.05313574,-0.021124365,0.010886277,-0.0054659913,-0.013487985,-0.008567653,0.03329498,-0.079796016,-0.038198765,0.036151957,0.090936214,-0.00037893487,0.00904458,-0.024271429,-0.010531124,0.02180474,0.009576558,-0.11223616,0.085015215,-0.02569942,-0.028811207,-0.016101386,0.06848755,-0.047206543,0.0368734,0.031100443,0.02428166,0.013009137,0.04919442,-0.049295515,0.016871618,0.009215303,-0.053884104,0.0045305756,0.027921898,0.033572238,0.02495504,0.026462225,0.06742644,0.008016786,0.10822956,0.0976998,0.038148038,0.060611315,0.062307373,-0.010339113,-0.047386486,-0.028563784,-0.012988465,-0.08094871,-0.03378104,-0.038357504,0.061107524,0.029577704,-0.06463767,0.021865396,-0.08811291,-0.031268958,0.04579271,-0.012209435,0.017916692,0.025970886,-0.06794337,0.044033445,0.053821974,0.051155746,-4.5234827e-08,-0.02609851,-0.03285393,0.027807074,-0.056212265,0.054831628,-0.01281078,0.065161735,0.001932216,-0.019092644,-0.022176402,-0.038583983,0.07337583,0.052489344,-0.04024678,0.046498,0.053213153,0.061067924,0.0072417706,0.019965693,0.09535393,-0.05375863,-0.039347254,-0.14910032,0.04549697,0.025133386,-0.04861468,0.05601928,0.03142081,0.040414028,-0.022201456,0.08313488,0.039991308,0.08556816,-0.03670858,-0.03942533,0.019754738,-0.067337856,-0.042215288,-0.08345092,0.034514263,-0.05475865,0.023795288,-0.038312297,0.0022579299,0.020329904,0.0132603925,0.033267908,-0.027606389,0.025865147,0.033946294,0.07595179,-0.031922977,0.02493941,-0.06849557,-0.11347712,-0.00413233,0.034043845,0.015072835,0.03653927,-0.0055942764,0.019348746,-0.022015503,0.12053336,-0.03565607 +3.1.1.82,"This enzyme forms part of the chlorophyll degradation pathway, and is found in higher plants and in algae. In higher plants it participates in de-greening processes such as fruit ripening, leaf senescence, and flowering. The enzyme exists in two forms: type 1 is induced by senescence whereas type 2 is constitutively expressed [1,2]. The enzyme is highly specific for pheophorbide as substrate (with a preference for pheophorbide a over pheophorbide b) as other chlorophyll derivatives such as protochlorophyllide a, pheophytin a and c, chlorophyll a and b, and chlorophyllide a cannot act as substrates [2]. Another enzyme, called pheophorbide demethoxycarbonylase (PDC), produces pyropheophorbide a from pheophorbide a without forming an intermediate although the precise reaction is not yet known [1].",384,0.99999994,-0.0764727,-0.019381879,-0.060068358,-0.052015275,0.09397634,0.0656323,-0.04863626,0.050668158,0.05661053,0.018585294,0.012920837,-0.040958308,-0.09270866,0.062137276,0.03113966,0.12441216,-0.14827806,-0.015596405,-0.015885763,-0.03500882,0.05530708,-0.0009234941,-0.07323929,0.002991205,0.017485484,-0.037729796,-0.013232993,-0.0029313494,-0.0029544279,-0.050876155,0.008006401,0.037332803,-0.051367756,0.020467775,0.052749977,0.08513959,-0.07377295,-0.07910238,0.0065235454,-0.0046383324,0.033107996,0.0147199,-0.100866966,-0.05089413,-0.10840243,0.030152384,-0.006114914,0.02265386,-0.029942334,-0.04738453,-0.006171176,-0.02528477,-0.049078558,0.009722463,-0.026343945,0.0050910865,0.035153084,0.062956735,-0.002403962,-0.0053627384,-0.02312231,0.0030748867,-0.007830367,-0.043926857,-0.026168039,-0.0049484977,0.0138730975,-0.08565529,0.02625104,-0.03801844,-0.095523655,-0.079481594,-0.022576174,0.029081088,0.043283153,-0.0019112778,0.032989413,-0.022716856,-0.051911358,-0.05343764,0.024654252,0.05556536,-0.022394419,0.034574978,0.05591241,0.024431257,-0.034422133,-0.005387407,0.058981955,-0.015230172,0.06490296,0.02778026,-0.044053115,-0.012942102,-0.036309034,0.10840822,-0.00087358995,-0.07995569,-0.0061717657,-0.045618944,-0.032205198,0.010683794,-0.11816973,-0.13469386,-0.0400254,0.07620104,-0.0009213973,3.752558e-05,0.054265417,0.0067949286,-0.045577917,0.040220175,0.03325262,-0.0027352266,-0.014734476,0.087106645,-0.004548044,-0.023340654,0.020469736,-0.041481674,0.018518923,-0.074244425,0.011309612,0.08664462,-0.045772023,0.04385725,-0.07303493,5.447274e-33,0.035115264,0.01139164,-0.024200981,-0.014556922,0.007993025,-0.024393603,-0.022736298,0.042146724,-0.059245095,-0.14194468,-0.019636605,-0.099767305,-0.02726258,-0.022866137,-0.0094974395,-0.020979857,-0.002508207,0.035169747,0.0014794552,0.003239621,0.014036253,0.07194596,-0.05228149,0.051876847,0.060455907,0.040377147,0.0028156764,0.04522374,0.05200674,-0.04663958,0.025444292,-0.06262221,-0.08772731,0.04187378,0.037060704,0.003270069,-0.07189948,0.005341644,-0.022627166,0.07403706,-0.06946753,0.0022794928,-0.0016331272,0.017080937,0.08445847,-0.08352209,-0.040199958,0.035595257,-0.024272911,0.034586813,-0.023214862,0.015459508,0.09794129,0.05661271,-0.0823129,0.012459547,0.010203157,-0.07711492,0.025931258,0.006720493,0.037615992,0.040505406,-0.027824672,-0.009872139,0.041119087,0.017733596,-0.05069102,-0.002284453,-0.016789531,0.089569435,-0.011777078,-0.04243033,0.027654972,0.05014839,0.12617275,-0.07581605,-6.451791e-05,0.022450916,0.040781334,0.01071428,-0.02077907,0.0063630627,0.04552314,-0.06843661,-0.085051626,-0.044494167,-0.017705813,-0.104509704,0.0018187766,0.03461405,-0.027119651,-0.12580717,0.0016759423,0.0316265,-0.024943972,-6.4559604e-33,0.02737245,-0.07782486,0.023115093,-0.054167874,-0.056664106,-0.014198021,-0.018335458,-0.0030698825,-0.06566455,-0.03247082,0.050658934,0.03833625,-0.045203745,0.029204745,0.04584766,-0.002803996,0.023606326,0.12349369,-0.0147925895,0.05277208,0.008655174,0.10365015,-0.003550523,0.03762702,0.061068453,-0.028320298,0.00042157032,0.10466885,0.096001185,-0.024742698,-0.06711488,0.04383256,0.0056081126,0.020392967,-0.0043479875,0.01893719,-0.10359355,-0.05142704,-0.009998851,0.094737135,0.054259025,-0.01648763,0.018959641,0.011654999,0.019844122,0.03886905,-0.11762478,0.06408726,0.05381681,-0.03359061,0.024605576,0.12151057,-0.0026917688,0.030761864,0.06542408,0.023179954,0.055787493,0.0194112,-0.0146727525,-0.040291067,-0.0045109685,-0.053047333,0.033159986,0.0597143,0.040041007,0.056803547,0.021822842,0.09103973,0.010378702,0.05609578,0.040255856,0.06813057,0.054791227,0.026968589,-0.07929273,-0.06571589,-0.026890287,-0.007408355,-0.0140548805,-0.029421719,0.004340196,0.0004284515,0.02552328,-0.08533662,-0.04556172,-0.051654793,0.0034526456,0.05722283,0.0022947278,0.01502521,0.018516952,-0.059577145,-0.00073507184,0.082756326,0.077476986,-4.8418265e-08,0.0162292,-0.023384068,0.031227374,-0.1162885,-0.008959319,-0.05834368,0.025938213,-0.016722878,0.010694853,-0.03812263,-0.06359564,0.058703426,0.05195755,0.011129425,0.04077239,0.041487586,0.0035740077,-0.015888898,0.027149532,0.03343559,-0.0718975,-0.040862557,-0.13239357,0.043781977,0.015664084,-0.0012921519,0.026047233,0.07758604,0.027003642,-0.0088644205,0.037489165,0.049490742,0.036298756,0.0020784207,0.028967565,0.02780375,-0.06370534,-0.044480603,-0.080362804,0.08088266,0.0117961755,0.0089858575,-0.04136368,0.025415495,0.08086435,-0.012011651,0.055404514,-0.041726567,0.021685457,0.045422647,0.049570665,-0.03199395,-0.0022084196,-0.098691665,-0.121015616,-0.039662454,-0.02497698,-0.00020147109,-0.048263688,-0.066657424,0.03427411,0.014585491,0.17505291,0.05013038 +3.4.22.66,"Viruses that are members of the Norovirus genus (Caliciviridae family) are a major cause of epidemic acute viral gastroenteritis [4]. The nonstructural proteins of these viruses are produced by proteolytic cleavage of a large precursor polyprotein, performed by a protease that is incorporated into the polyprotein [6]. Cleavage sites are apparently defined by features based on both sequence and structure since several sites in the polyprotein fulfilling the identified sequence requirements are not cleaved [1]. The presence of acidic (Asp), basic (Arg), aromatic (Tyr) or aliphatic (Leu) amino acids at the P1' position results in only minor differences in cleavage efficiency, suggesting that steric or conformational constraints may play a role in determining specificity [1]. Changes to the amino acid at the P2 position do not alter cleavage efficiency [1,2]. Belongs in peptidase family C37.",384,0.99999994,0.0076911403,-0.11121323,-0.073931485,-0.09399196,0.04307666,0.013472303,-0.01871379,0.036891356,0.1256669,0.0028327792,0.03304592,0.053497583,0.019293724,0.08884938,-0.007927957,-0.058993552,-0.05570159,-0.0537832,0.042031486,-0.009355855,0.033747096,0.042888105,0.01510234,-0.058716964,-0.033960573,0.015550457,0.016466815,0.05738088,0.055338413,-0.03130932,0.049636927,-0.06765768,0.06553551,-0.016632902,0.022755036,0.022369731,-0.052744936,-0.01850389,-0.014204432,0.051761415,0.050792154,0.060882505,-0.036176994,-0.021960324,0.04948295,0.029070795,0.00514227,0.064183794,0.025214897,-0.04706138,-0.030028375,-0.023721837,-0.00023615276,0.030068249,-0.07264052,0.021190219,-0.10267891,-0.022287512,-0.02393641,-0.004261017,-0.03856027,0.053354055,0.058126945,-0.025735391,-0.019635893,-0.04637636,0.0678242,0.0369215,0.04447038,0.08126688,-0.0904526,-0.03379494,-0.11877097,0.08383748,-0.027014725,0.056826912,0.0032152585,-0.02282191,-0.012946549,-0.039563727,-0.017176814,-0.023256239,0.05549896,0.11212904,-0.034532703,-0.0033729665,0.040251758,0.006717053,0.05418021,-0.02443531,0.023101196,-0.04226672,0.081397116,-0.018668301,0.009090803,0.027961146,0.019396832,-0.082583226,0.051386073,-0.01751113,-0.065171525,-0.045430433,0.019442014,-0.046067853,0.012712424,0.021789318,-0.07488824,0.10096082,0.043785453,-0.024930917,0.05240657,0.052432492,0.05693763,-0.11044651,0.042827148,0.06450931,0.0003723941,-0.04778383,-0.022740025,-0.019233374,-0.008145063,-0.05678439,0.03052168,0.07586185,-0.043647952,0.028464448,-0.10539505,5.1516947e-33,0.007670996,-0.014733517,0.029092992,0.00758902,0.0010492544,0.0018643935,0.008440469,0.029923476,-0.002886933,-0.0399719,-0.042764436,-0.104484014,0.07328602,-0.010565387,0.045854434,0.008588816,-0.0014075643,0.04528366,-0.04372734,0.026427018,-0.004096444,0.0443181,0.078958035,-0.057675295,0.056331158,0.00027134785,-0.041768815,-0.013213769,-0.025481356,-0.0743635,-0.008993796,-0.03070459,-0.10360574,0.09258436,0.003537189,-0.012294889,-0.0145413475,-0.08124005,0.014402032,0.064025395,0.038508087,0.01860972,-0.017953841,-0.010873665,0.06844279,-0.03955184,-0.055206154,0.13505489,-0.0143796215,-0.018504508,0.052489642,0.066991374,0.08182636,0.034396615,-0.10394561,0.0049376963,-0.006387671,-0.00013988752,-0.003740257,-0.013657365,0.045447804,-0.0030565022,0.0044350857,0.050460204,-0.045513898,-0.047792487,-0.02238741,0.029683385,0.059750076,0.09445316,-0.033912357,0.039053082,0.017939158,0.0032601387,0.047948796,-0.03795133,-0.11489366,-0.008728445,0.110333726,0.088700585,-0.066125736,0.05020453,0.086593665,0.011884228,-0.12786202,-0.071824975,0.07272235,-0.063846186,-0.028040195,0.073246256,-0.012892005,-0.0039437227,0.027017593,0.07989514,-0.024989134,-6.38487e-33,0.027088879,-0.09512891,-0.012616968,-0.029336747,-0.039997417,0.020417783,0.039112434,-0.032211985,-0.01901584,-0.09583459,0.041758157,0.00018487943,-0.0036649876,-0.08782539,0.036852688,0.016438764,0.010178979,0.11058255,-0.042857084,-0.035767656,-0.03817048,0.00035458602,-0.03081647,-0.057837512,0.021139298,0.008083286,0.03040289,0.03737377,-0.043405466,0.093511276,0.0115104355,0.11402251,-0.03602967,0.01851839,-0.011141116,0.074976444,-0.038743533,-0.050351344,0.07292214,-0.061258446,0.017518317,0.09384932,0.011836138,0.082614265,0.028879367,0.024325347,0.054802097,0.071434036,0.013675439,-0.053897284,0.0014986808,-0.0709367,0.019148296,0.03837868,-0.027020928,0.03260831,-0.0034644757,-0.019832084,0.012140304,-0.0064357542,-0.028226728,-0.072215095,-0.0012120603,0.036098957,-0.010282279,0.00051189016,0.015791276,0.07176036,0.0799918,-0.12364251,-0.011396984,-0.03277759,0.044396978,-0.02530721,-0.047325082,0.016843317,-0.020863775,-0.011864336,0.0009521169,-0.10030832,-0.096837014,-0.008293547,-0.08917485,-0.053376574,0.031596217,-4.2855176e-05,-0.02622772,0.020501496,-0.005270599,0.032385472,-0.022098085,-0.07861397,-0.0009735501,0.05130179,0.022229318,-5.1492158e-08,0.09271376,-0.020319143,0.0028548595,0.0030853497,-0.01081552,0.031544592,-0.06947809,-0.028228128,0.051315557,-0.016054897,0.046812914,-0.012913219,-0.038050104,-0.011982911,6.668703e-05,0.038314782,-0.10839493,0.09925881,-0.09162659,-0.02751685,-0.10490443,0.013899218,-0.12369276,-0.031993266,-0.013417257,-0.03740629,-0.09225337,0.0034609318,0.055777475,-0.08407003,-0.028321683,0.039203253,0.009632428,-0.030316897,0.068476826,-0.0067686406,0.02943156,-0.039015893,0.03012518,0.030125827,0.05346523,-0.07521191,-0.02144431,-0.014435929,0.046801038,0.002986083,-0.08092342,0.023708617,-0.021955937,-0.043529443,0.05559032,0.021768458,0.008529428,-0.06487611,-0.10769955,0.0042532883,-0.045271885,-0.036900762,0.021277959,0.0030743382,-0.04794421,-0.009712049,0.14050518,-0.015483567 +4.3.1.22,Forms part of the L-phenylalanine-catabolism pathway in the anoxygenic phototrophic bacterium Rhodobacter sphaeroides OU5. NADPH is oxidized more slowly than NADH.,384,0.99999994,-0.08090993,-0.041147977,-0.02440462,0.051412825,0.04047703,0.049609784,-0.029968921,0.0012407278,0.008498369,0.047783956,0.061093323,-0.01579533,0.03176438,0.022532554,-0.0014751041,0.061901767,-0.1508272,-0.03204279,-0.014454942,0.042426676,0.035643697,0.03762956,-0.055392284,-0.025140887,0.06402152,-0.010193259,0.052342117,-0.044365965,-0.0896631,-0.033795018,0.03121398,-0.025419114,0.001229798,-0.041099936,0.05297967,0.0744174,0.0051214034,-0.08615001,0.062080197,0.04546825,-0.058955118,-0.028786372,-0.016753042,-0.044860397,-0.087990046,0.013236945,0.015133482,0.0014241841,0.01971101,-0.054610956,-0.06303181,-0.01534931,-0.021107683,0.00270707,0.0048706587,-0.0082163885,-0.013651985,0.023405243,0.011263535,-0.06760651,0.007280992,-0.069688104,-0.03282239,0.0075732153,-0.042388767,-0.064694956,0.06144096,-0.09216006,0.00063752354,-0.050931342,-0.076719984,-0.007695142,0.055661898,-0.030583506,-0.032540206,0.055859983,0.03727781,-0.040455688,0.03098909,-0.0022626438,0.0384501,0.023200568,-0.043393236,0.05070888,0.05834318,-0.047709923,0.02749077,-0.012740571,-0.026930215,-0.01519945,-0.005918528,0.011722457,-0.018050253,-0.027272986,-0.121778116,0.024753695,0.055593815,-0.012473783,0.0084253745,-0.028154068,-0.025373776,0.073319525,-0.008765857,-0.06646017,0.009860165,-0.044840295,-0.041933704,0.11527325,-0.0021903021,-0.0015062495,0.08619791,-0.019433277,0.0045528444,-0.036937155,0.021600654,0.0760752,-0.0154813565,-0.06619502,-0.16323446,-0.015619647,-0.06309714,-0.009379788,-0.0010127745,0.004691016,-0.09467563,-0.048065897,-0.0772496,4.191695e-33,0.1364353,0.034243066,-0.0025086892,0.011426308,0.017400792,0.024146609,-0.107050784,0.033484213,0.009477197,-0.102357306,-0.098310396,-0.053866703,0.018794745,-0.030205676,-0.033387937,0.043322455,-0.09744012,-0.052503206,0.0008258062,0.05253596,-0.0041364986,0.013746258,0.01366069,0.03178289,0.019139262,0.012666878,0.0116237635,-0.06630348,-0.048763342,-0.0038103878,0.08593111,-0.09440028,-0.05828821,-0.004148313,0.049775325,-0.0700817,-0.025125813,0.0085801855,-0.026994834,0.009519443,-0.056426004,0.03766827,-0.025881156,-0.007971451,0.05791149,0.038007278,-0.012581932,0.08510707,-0.012982061,0.11072616,0.03440353,-0.018696252,0.09313476,-0.013386077,-0.06832712,-0.0012573164,-0.022778852,-0.032062616,0.015051635,0.032408014,0.11730167,0.0807521,0.05784467,0.08474026,-0.007104978,0.06792614,-0.00087169016,0.028259981,0.048438374,0.012700004,-0.03683472,0.014735365,0.10433653,0.005842619,0.024737742,-0.028256536,-0.017064422,-0.025447095,0.004519929,0.07373434,-0.006315769,-0.014842825,-0.062370908,-0.060317773,0.006377617,0.0046467935,0.03293619,0.00046095016,-0.048867878,0.013325905,0.11781351,-0.071332924,-0.003074451,-0.099601254,-0.010239467,-4.8923432e-33,0.15326713,-0.06864522,-0.011711665,-0.1301023,0.025925724,0.035022438,0.041025165,0.053739224,-0.032388803,-0.052207615,0.06411957,0.10709603,-0.019716756,0.015781308,0.05111284,-0.048325095,0.019510828,0.043254003,-0.011524106,-4.944292e-05,0.011390025,0.014623243,0.029399624,0.037775308,0.043414146,0.01868753,-0.050804555,0.028118819,0.038722795,0.057920713,-0.029212909,0.067842886,-0.03350554,-0.02242654,-0.008169029,0.06929007,-0.08306925,-0.015982494,0.033302344,0.071789354,0.029757684,-0.059629973,-0.0753145,0.045955904,0.007414,0.001106994,-0.13363485,-0.028992115,-0.014545905,-0.10738818,-0.011899245,0.06030997,-0.031760763,-0.026616206,0.02562066,0.06768437,-0.07058478,0.035170317,0.011578496,0.022485994,-0.041565385,-0.08564479,0.043379225,0.06330133,-0.029615909,0.06889373,0.05398838,0.038342483,0.023712287,-0.03969256,0.045965604,0.022249948,0.04219047,0.05443201,-0.00069100416,-0.06954584,-0.02520213,0.039173484,-0.032301284,0.026317367,0.031898297,-0.04662808,-0.0036256486,-0.03493714,0.04974946,-0.03207557,-0.022823596,-0.058328714,-0.021008577,-0.039672896,0.014291032,0.049873736,0.010927494,0.030719234,0.08205899,-2.8720775e-08,0.023058873,-0.027382506,0.15030089,0.003959157,0.08542272,0.051984537,0.036431517,0.032940935,0.029820262,-0.023682669,0.07480536,0.07481984,0.028433617,-0.025402173,0.030431002,0.06775639,-0.05994528,-0.045057636,-0.01963764,0.046659328,-0.1097424,-0.07061141,-0.104074806,0.05755533,0.03145031,0.008961054,0.024225073,-0.040041383,0.018984897,-0.08384686,0.09149549,-0.012942565,0.020339657,0.009012975,-0.07644508,-0.032073487,-0.010232531,-0.0008785431,-0.07482445,0.037676375,-0.09213749,0.0076210345,-0.06885937,0.034844477,0.024469124,0.07409045,0.008718145,0.021958984,-0.026841348,0.0382312,-0.0034745529,0.009805926,-0.01833408,-0.004582725,-0.13600634,0.013597222,0.03673301,0.0054706982,-0.039671905,0.029897483,-7.215754e-05,0.07619951,0.07142062,0.011921232 +5.1.3.23,"This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens [1]. The enzyme is highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates [1].",384,0.99999994,-0.04668573,-0.06120628,-0.1241393,-0.08744242,-0.011199204,0.038451266,-0.020340739,0.04086713,0.02064164,0.097110875,-0.024577582,-0.07302042,-0.025134059,0.010223756,-0.076455414,0.056165412,-0.014357296,-0.05789948,0.018859012,0.011829597,0.05287969,0.0977406,0.013321626,0.021438936,0.004285313,-0.01896735,0.089277685,-0.0021281238,-0.03155521,-0.07178867,-0.079473004,-0.090049334,0.07484339,-0.07319575,0.09216024,0.06710346,0.04610761,0.04680672,0.035443135,0.0046625445,0.0051489105,0.0031328544,-0.045742147,0.030564014,-0.014536502,-0.014058165,-0.06558056,0.1058573,0.038847715,-0.009326788,0.008370522,-0.069309294,-0.08171727,0.09279476,-0.0023290666,0.036823034,-0.042464674,0.023677092,-0.026710222,0.028403364,-0.063855715,0.004156046,0.076433204,-0.027300578,0.015684092,-0.014759391,0.08491786,-0.04999124,-0.001770551,0.015978457,-0.043974757,-0.062911876,0.0055064145,0.0471044,0.061234243,0.04410163,0.030289147,-0.040963072,0.061756413,-0.08357015,0.034353357,-0.02938238,0.020566119,0.17652342,-0.05819258,-0.07849694,-0.027569521,-0.076952145,0.034675296,0.0067099687,-0.049235277,-0.02117353,-0.009116804,-0.020736236,-0.08115369,0.010323663,-0.0034814377,0.02967727,0.093520604,-0.044113964,-0.025258912,-0.033413813,-0.004186882,-0.0782587,-0.043560997,-0.029331453,-0.00034515237,-0.052640155,0.10209651,0.0038424884,-0.0108177075,0.071084924,0.0008274132,-0.018621262,-0.07628718,0.03781745,0.05458231,-0.088975616,-0.05389586,-0.06932163,-0.011275403,-0.046657,0.07815638,-0.025122525,-0.017468207,-0.04255717,-0.02227073,4.576418e-34,0.036427345,-0.026925754,0.024889233,-0.004530834,0.03951899,-0.04462513,-0.04740578,-0.047956686,-0.02169951,0.013238929,-0.0912291,-0.09309564,0.007379713,0.09191483,-0.00756598,0.09270446,-0.017933836,-0.06230646,-0.02919133,-0.018543351,-0.0073048435,0.111330725,-0.014425788,-0.031990893,0.13732646,0.069353916,0.03531976,0.028872821,0.06557499,-0.03237692,0.079021916,-0.014708454,-0.119558565,-0.051992346,0.050058555,0.0046855332,-0.039165966,-0.00964424,0.002733222,0.06693436,0.013745656,0.003561475,-0.028623013,-0.015562529,0.057735477,-0.022833295,-0.03734567,0.039512828,0.02033783,0.053888295,0.05363972,-0.0466597,0.08885558,0.059520148,-0.0043383907,-0.026260868,-0.0589189,-0.037163164,0.054718606,0.08989209,0.10089268,0.051187634,0.017032523,0.022221025,-0.03589292,-0.04241242,-0.057885613,0.028478391,0.036258373,-0.04569592,0.025880273,-0.05810841,0.018493481,-0.00837877,-0.02745834,-0.09119698,-0.0010923777,0.047115512,0.029855281,-0.044068366,0.022697225,-0.052923374,0.0871484,0.007247965,-0.13217983,0.018080464,0.036126867,-0.027191747,-0.03887142,-0.007205369,-0.017222803,0.018914362,-0.02981031,0.07762958,-0.02312366,-2.7887803e-33,0.07640566,-0.076155655,0.086061984,-0.06152294,-0.0065197656,0.046219192,0.073523104,-0.0120979315,0.032763515,-0.0028232299,0.07660524,0.012486543,-0.00842929,0.029284332,0.034561362,0.029929804,-0.079360105,0.07164161,-0.08467919,-0.033376247,-0.039731346,0.03538093,-0.015758596,0.051928837,0.052674588,-0.013827034,0.023744404,0.10322717,-0.013093238,0.037091482,0.02214093,0.07220175,-0.015512594,0.027991554,0.009738662,0.009891002,0.043107416,0.01181476,-0.09319966,-0.031009112,-0.038644258,0.04961999,-0.022876961,-0.056660138,0.02600849,0.08835372,-0.018922085,-0.0062426133,-0.042676296,0.0061405827,0.06621996,-0.038498726,0.062138528,0.02666657,0.025404286,0.065136164,-0.017792515,-0.0037318217,0.07503185,-0.046348624,-0.022569964,-0.07577967,0.06684941,-0.019465024,0.06360381,0.08907881,0.02017582,-0.011015464,0.05171191,-0.024507755,-0.05383644,0.028136212,-0.040444832,0.025284607,-0.070692204,0.01659038,-0.07919611,-0.03988546,0.031039402,-0.0025804357,0.014646734,-0.020100035,0.013864696,0.010952323,-0.042084157,-0.021851948,0.07849946,0.07365853,-0.021800421,0.071015194,-0.023746133,0.01894021,-0.06651812,0.021354355,0.08116151,-5.1370726e-08,0.0633587,-0.027759945,0.011460522,-0.015214845,-0.021943426,-0.029106183,0.0029249273,-0.013048607,0.053810332,-0.008639292,-0.017957872,0.07508776,0.019015621,-0.015835121,0.0071121263,-0.006345843,-0.05460389,0.0093293665,-0.03712747,0.016117778,-0.09889992,0.000534166,-0.12708291,-0.031295646,0.018724663,-0.09482019,0.037667923,0.01942309,0.037614614,-0.027147569,-0.08632092,0.04447253,-0.011279825,-0.1019341,-0.028994,-0.0086724395,-0.040081076,-0.030597446,-0.033211596,0.06537171,0.06902531,-0.018771054,0.035002727,-0.020229198,0.031175226,-0.044102333,-0.04216998,0.03776836,-0.027627636,0.020413298,0.05668828,-0.013628428,0.0034428542,-0.046583626,-0.11065803,-0.013016281,-0.11931913,-0.03779261,-0.030177351,0.014292794,-0.034813732,-0.022504441,0.11593685,-0.02626605 +1.1.99.32,"The product, L-sorbosone, is an intermediate in bacterial 2-keto-L-gulonic-acid formation. The activity of this membrane-bound enzyme is stimulated by Fe(III) or Co2+ but is inhibited by Cu2+. The enzyme is highly specific for L-sorbose as other sugars, such as glucose, mannitol and sorbitol, are not substrates. Phenazine methosulfate and DCIP can act as artificial acceptors.",384,1.0,0.005702857,-0.08500749,-0.116263226,-0.008898875,0.079424046,0.110605314,-0.03848729,0.02367529,0.03355565,0.0011859408,0.013915765,0.02947789,-0.07861092,-0.0015282423,-0.04658559,-0.0045576314,0.04910421,-0.04887521,0.03065291,0.05431977,0.1392649,0.0062131183,0.027782898,-0.05565812,-0.013583957,0.019347025,0.034271,-0.10822559,-0.018395934,-0.12829003,0.003831354,0.013254742,0.021510113,-0.0071673463,-0.03732534,0.04067135,-0.041686162,-0.024125002,0.06089371,-0.019967837,-0.003965162,-0.11240495,-0.013552453,-0.016645372,0.0024774268,-0.09580761,-0.016771263,0.051854547,-0.0051051173,-0.034338277,-0.031536218,-0.022372415,-0.028398821,0.0341154,-0.07756328,0.053700488,-0.09638802,0.016671855,0.03352459,0.0076916018,0.040335234,0.08586101,-0.0044918223,0.013209609,0.03833959,-0.0980676,0.01781622,-0.06097297,0.07261805,0.025896562,-0.008359175,-0.0649497,0.019824617,-0.004524803,0.070628375,0.049229942,0.039326575,0.03677905,0.07991898,-0.025093213,0.03706834,-0.00036772527,0.032466616,0.056441307,-0.017317483,-0.0603204,-0.06437032,0.10186273,0.07848362,0.0029823007,0.050609965,0.0022531315,-0.022463335,0.047701642,-0.1032235,-0.046337735,0.04369041,0.0012176791,-0.0052322666,-0.011984048,0.01114282,0.055623192,0.005214234,-0.07186082,0.01843704,-0.022405194,0.015394299,0.06898365,0.040513817,-0.03132028,0.020317385,-0.01068894,0.014933931,0.008932345,-0.04682575,0.040281564,0.13294627,-0.10526124,-0.06059287,-0.06783395,0.019554041,0.003688038,0.021258848,0.008200504,-0.03400189,0.053045854,-0.09769912,1.9601835e-33,0.06645319,-0.04814648,0.030861408,-0.04432154,-0.054472167,-0.007951736,-0.073991075,-0.03556987,0.0067429976,-0.026989482,-0.09790364,-0.0672951,0.042538602,0.1328042,4.8159298e-05,0.011862069,-0.030292276,-0.06938601,0.15461972,-0.032858595,-0.052558567,0.058986187,-0.047040135,0.024985908,0.072676055,0.05904741,-0.0059247203,-0.028673325,0.02569146,0.015466815,0.11352601,-0.07260772,-0.030234724,0.036749598,0.06278223,0.04695109,-0.07135304,0.016186697,0.02191827,-0.0056151673,-0.021019062,0.007952659,-0.018068478,0.007791925,0.012443905,-0.036186546,-0.07693946,0.15063691,0.002131035,0.017476998,0.051147193,-0.011169259,-0.033019412,0.08129245,-0.0621388,0.06917635,-0.022443974,0.04887732,0.055479728,-0.010328665,0.0090709245,0.03435574,-0.05371675,0.09177463,-0.0124942595,0.00041219138,-0.06893427,-0.011296087,0.015316085,0.00957749,-0.09974069,-0.03356734,0.09344973,-0.0002253447,-0.019818848,-0.016321482,-0.073632255,-0.028330183,0.04096982,0.056774527,0.057751536,-0.07371432,-0.018129854,-0.030547641,-0.094593264,-0.011002123,-0.08028951,-0.050365794,-0.0050267973,0.004279215,-0.040778223,0.0022513266,-0.038289793,0.050635733,0.01052892,-3.6158713e-33,0.06897185,-0.09654216,0.12553653,-0.005791182,0.029498566,0.007930055,0.0051607518,-0.17080554,0.028533459,0.008008408,-0.0054718466,0.006215972,0.07556277,0.0025204732,0.058180727,0.04564025,-0.08076919,0.030359978,-0.01233572,-0.019956335,-0.059340786,0.08272987,-0.019679999,0.04107744,0.01439773,-0.010109235,-0.0032806797,0.01034345,0.014524271,0.06534915,0.046645,-0.038615666,-0.01712581,-0.10800305,-0.028102659,0.02617833,-0.014706459,0.0066071977,-0.015245594,-0.01848504,-0.023911746,-0.031468097,-0.021963377,0.0056140744,0.10643863,0.024909217,-0.010225893,-0.076351896,-0.018145273,0.012743462,0.0041874577,0.0072295177,-0.031350218,0.0062278057,0.031878635,0.03162683,0.0054442077,-0.07026775,0.006597928,-0.040448066,-0.021970648,-0.06288741,0.02484102,-0.07264415,0.09737879,-0.012070058,0.011725039,0.14432567,0.059050262,-0.07895749,0.08688747,-0.025805341,0.027156938,0.049653955,-0.027297396,-0.07232417,-0.07788714,-0.032177694,-0.005015421,-0.035278134,-0.021624384,-0.0019893688,0.083606,-0.027261788,0.00930345,-0.05855884,0.017888008,0.060483865,-0.0070535024,0.059168275,-0.026916057,-0.044299383,-0.080768846,0.069956966,0.0819402,-4.2905633e-08,0.03285575,-0.026806142,0.01575265,-0.035641912,-0.006064496,0.044080768,0.03198584,0.022400992,-0.02294558,0.0026418103,-0.037292253,0.106322184,-0.016869793,-0.0068794005,0.046883807,-0.011545792,-0.031907897,0.0390168,-0.046874188,-0.04642947,-0.06210928,-0.033231147,-0.0470484,0.024424367,-0.008465464,-0.04755964,-0.012912575,0.02050076,-0.009972424,0.0073597184,-0.035717107,0.08554945,0.049016938,-0.019686004,-0.045883548,0.0050238622,0.022384742,-0.040153954,0.006692044,0.060833193,-0.015605319,0.048239935,0.012053266,0.01053851,-0.024503337,-0.002464158,0.045676567,0.046966955,-0.021048652,0.026022783,-0.009274683,-0.010984243,-0.051608395,-0.0016735706,-0.061450843,0.031278335,-0.07685306,-8.573652e-05,0.016773304,-0.063669294,0.01862628,0.010606799,0.14459997,-0.06076027 +2.7.7.65,"A GGDEF-domain-containing protein that requires Mg2+ or Mn2+ for activity. The enzyme can be activated by BeF3, a phosphoryl mimic, which results in dimerization [3]. Dimerization is required but is not sufficient for diguanylate-cyclase activity [3]. Cyclic di-3',5'-guanylate is an intracellular signalling molecule that controls motility and adhesion in bacterial cells. It was first identified as having a positive allosteric effect on EC 2.4.1.12, cellulose synthase (UDP-forming) [1].",384,1.0,-0.11581565,-0.15433513,-0.027740275,-0.016583212,0.0005748811,0.0052985875,0.013227222,0.039544076,0.043409217,0.015683351,0.1011121,-0.022602597,0.005977107,0.06644499,-0.05369991,-0.04580381,-0.04643381,0.039556194,-0.024434457,-0.07318241,0.065830156,0.06508226,-0.06794106,-0.062755086,0.04232034,-0.021170424,0.010720264,-0.044763073,-0.021623977,-0.03401874,-0.043670256,0.042084444,0.080360174,0.0076408116,0.060523104,0.13237514,-0.047717072,-0.031135613,0.008318871,-0.040846173,0.031148728,-0.02987483,0.08957095,-0.000271929,-0.0032910842,0.03140969,0.07553755,0.019201083,0.024919126,-0.024836352,-0.04640675,-0.07369362,0.032474685,0.027304249,0.051381584,0.027860055,-0.07898154,0.042756397,-0.023290072,-0.004994151,-0.0019496375,0.0091279335,0.018479904,-0.004860702,0.0023710693,-0.026559878,0.043446302,-0.038687956,-0.09323427,0.036977857,-0.0058594393,-0.022688475,-0.050865367,0.008498482,-0.09227304,0.09489064,-0.058170788,-0.012905234,0.015843304,0.036307987,0.07725551,0.07666581,0.17550437,0.044700786,0.033727515,-0.029489553,0.086576164,0.022852656,-0.012630433,-0.028780501,0.07353659,0.025759662,-0.06352424,0.052074168,-0.11756497,0.007555908,-0.04678082,-0.018911712,-0.01260426,-0.032718375,0.041754745,0.041944664,0.039787095,-0.04444782,0.017339475,0.01302322,0.009834711,0.028040467,0.020665625,0.03635123,-0.010449042,0.036652036,-0.00084174017,0.014829165,-0.042015724,0.05192795,0.026647013,-0.048518527,-0.0603113,0.02731704,0.02540101,-0.017282713,-0.04421045,0.019630274,-0.07908086,0.044245683,-0.03490906,2.3127592e-33,0.020090114,0.06357369,0.014321985,0.026934603,0.017078592,0.0061600613,-0.0567332,-0.01467056,-0.05047494,-0.017663967,-0.05181902,-0.032107648,0.028138416,0.087083295,-0.06454767,0.016174396,-0.06177119,-0.04085842,0.09012327,-0.023805311,0.03551981,0.004340609,-0.06156881,-0.031876236,0.040267494,0.026677798,-0.030423589,-0.036309116,0.1345504,-0.017742606,-0.020340146,-0.15397453,-0.050876338,0.0022395444,-0.006184526,-0.0049956157,-0.06037808,-0.060993563,0.0055558467,-0.008885463,0.009487119,-0.012734255,-0.028669005,-0.023770269,0.042145412,0.013844507,-0.012342709,0.025668653,-0.052189305,0.040178407,0.09671351,0.0018271041,0.046174146,-0.047372207,-0.076632835,0.021946426,-0.05105793,0.028636133,-0.017726716,0.047116157,-0.006396609,0.03531299,-0.019794874,-0.009368826,-0.04278768,0.090784825,-0.10836679,-0.09672984,0.05876494,0.11900389,-0.033936724,-0.08061264,0.04901574,0.056591038,-0.005428685,-0.036206394,-0.028565712,-0.018545864,0.06800587,0.024234308,-0.049202494,-0.055097166,0.0026289779,-0.0030789266,-0.07707775,-0.060678706,-0.021041509,0.01627998,-0.047051214,0.016733875,0.10134838,0.015502823,-0.028459173,0.09560234,-0.017082566,-3.0569969e-33,0.09936219,-0.057064526,0.051732987,-0.032939177,-0.043883488,0.030166378,0.02030404,-0.03949408,0.025773048,-0.055122726,0.07366552,0.008530984,0.028361809,0.010697221,-0.060336564,-0.025711792,-0.0031343524,0.03315835,-0.06367333,-0.025341924,0.032956302,0.038268164,0.0045115356,0.05275472,-0.00087919674,0.07167555,-0.030182501,0.0019832994,-0.007844376,0.10845405,-0.026457945,-0.00032161496,-0.09905569,-0.077059224,-0.007987198,0.040270858,0.006084856,0.024530774,-0.0205174,-0.0044443565,-0.0465328,0.04702967,0.054368194,0.1204109,0.032695465,0.104965664,0.009786522,0.07245147,-0.0139794415,-0.028111942,-0.032149307,0.019842423,-0.018814078,0.0029720524,0.0414947,0.049330432,0.068955466,-0.08362647,-0.08014675,-0.034489986,-0.0568777,-0.0691986,0.014313505,-0.066474885,0.038245175,0.09974673,0.03049656,0.11548403,0.050434593,-0.009714901,0.018504212,0.05054265,0.044345398,-0.03854075,-0.08320138,0.044187568,-0.014750063,-0.0003367508,0.018425733,-0.022663126,0.048093338,-0.0066725356,-0.07212031,-0.027673485,-0.029397914,-0.0667594,0.09084925,0.11082207,0.020390768,0.03226968,-0.056992922,-0.02649533,-0.054297354,0.09537833,0.04869919,-4.6546745e-08,-0.014623144,-0.043368462,-0.005315978,-0.1577648,-0.031561457,0.015133931,0.018551627,0.02509234,0.1087664,-0.016628327,0.0094501935,0.05983484,-0.05423691,0.05506165,0.035981905,0.050809253,-0.04920833,0.0037602237,-0.024181545,-0.028735055,-0.000929658,-0.045228492,-0.12142629,0.067913465,0.010833294,-0.06565215,0.0092187645,0.0466734,-0.062946126,-0.02809352,0.024028527,0.049312692,-0.020700421,0.042702924,-0.06655162,0.031319648,-0.026537517,-0.05659642,-0.029307343,0.004557945,-0.016165463,0.03373486,0.002324346,-0.03479512,-0.058016058,-0.0523631,0.059105653,0.020355282,0.014346624,0.0071325344,-0.01181274,-0.005846934,-0.030496262,0.022866195,-0.030486124,-0.0024943217,-0.025100153,-0.015029491,0.0068347896,-0.008487102,-0.08962469,-0.07578296,0.12495473,-0.020912876 +3.1.4.52,"Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65, diguanylate cyclase and an allosteric activator of EC 2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive [1]. It is the balance between these two enzymes that determines the cellular level of c-di-GMP [1].",384,1.0,-0.11603333,-0.046669304,0.008041353,0.012401709,0.02893964,-0.012905581,-0.030584393,0.06738149,0.007073063,0.0067216684,0.04250286,-0.04934284,-0.0028847314,0.013875271,-0.08035833,-0.02289482,-0.020492503,0.069681466,-0.039685473,-0.07042584,0.07028051,0.026054475,-0.035190124,0.016214073,0.060426503,-0.011948503,0.025498208,-0.005704502,-0.011657352,-0.0321296,-0.017984701,0.056793425,0.11648352,-0.0063173976,0.08663899,0.109785154,-0.02593062,-0.06310961,-0.008558878,-0.038569763,0.059805963,-0.01643188,0.04400143,-0.01843592,0.028386626,0.00520576,0.081080385,-0.030673098,-0.062484946,-0.02199473,-0.042390637,-0.0381078,-0.009241139,0.06302717,0.031692598,0.01149494,-0.096144065,0.04732508,0.037615772,-0.028379196,-0.037194237,0.011864145,-0.06793825,-0.02360573,0.014754397,-0.044087514,0.059941873,-0.0750204,-0.049251784,-0.004049846,-0.02373762,-0.02837096,-0.056769755,-0.015408083,-0.058015954,0.04018857,-0.0017397231,-0.090212,0.06811926,-0.0059010456,0.07113663,0.07937512,0.08513879,0.06273139,0.0027434807,0.00861783,0.06419355,0.041806843,-0.025233662,0.005228656,0.052297764,0.0828859,-0.03971349,0.037551057,-0.08701073,0.066622764,0.014503278,0.037893515,0.050818957,-0.004527262,0.04342138,0.07357879,-0.0066180653,-0.08657796,-0.016441913,0.0061066,0.027641581,0.02763665,0.026498951,0.05073176,0.028656358,-0.016207196,-0.030424407,0.023533959,-0.010953018,0.11945801,0.04510315,-0.055269226,-0.039881274,0.017707007,0.031993773,-0.0551213,0.017666653,0.024329923,-0.077043325,0.051164612,-0.05835712,2.5780272e-33,-0.017478865,-0.00891641,0.016004806,0.016141627,-0.008732295,0.040478855,-0.11116597,0.036769148,-0.011260925,-0.041296065,-0.07286866,-0.027863057,0.018429158,0.07431078,-0.069301754,-0.049462307,-0.03556955,-0.045114428,0.10398438,0.009479638,-0.007823866,0.011419688,-0.058730744,-0.013793843,0.058157735,0.032650713,-0.022868672,-0.042235926,0.09131665,-0.016244303,0.028643565,-0.09135422,-0.07979464,-0.007759716,0.036140684,0.004220688,-0.05600774,0.003990896,0.0063881367,0.05960337,-0.044855114,-0.010073591,0.014144657,-0.05045679,0.07798713,-0.025329942,-0.058975924,0.010355949,-0.0151069015,0.056242973,0.1071668,0.043081988,0.043501735,-0.045621276,-0.030967487,0.02806622,-0.046750028,-0.009020594,-0.012183764,0.063129075,0.049064778,0.07144217,-0.062244292,-0.00057858217,-0.025110878,0.0643824,-0.14761777,-0.052666184,0.028261336,0.049300313,-0.04295562,-0.0964,0.099318184,0.03649558,0.011560073,-0.03404884,-0.04836858,0.06484933,0.079156816,0.014002235,-0.047999997,-0.017583184,-0.0131029,-0.0038990725,-0.044009082,-0.056864463,-0.06865693,0.026980363,-0.04354065,0.057714943,0.055258382,-0.05408875,-0.06045482,0.07355685,0.022120338,-3.514561e-33,0.09273211,-0.011456802,-0.017884318,-0.046013266,-0.035531677,0.0006844969,-0.0009636974,-0.0991744,0.03722521,-0.04213138,0.12741217,-0.001148702,0.037848525,0.022841908,-0.0023745692,-0.018777082,-0.047393147,0.110277586,-0.07799048,0.015733788,0.018433653,0.06828976,0.015195723,0.053556208,0.0421808,0.017944086,-0.04408829,0.043891735,0.10660187,0.10738361,-0.05885126,-0.0007583007,-0.07449076,-0.076526515,-0.04601227,0.025988167,-0.03851682,-0.012881584,-0.00091768656,0.013815297,-0.02404601,0.017512538,0.06787845,0.09326125,0.06205092,0.12179512,0.044397082,0.037122164,-0.03154366,-0.0012791216,-0.0067367875,0.042513352,-0.06409664,0.008680977,0.042418174,0.032254353,0.051936258,0.0011918363,-0.071910545,-0.04838506,-0.034511544,-0.037007146,0.025446393,-0.05395969,0.035218325,0.09042296,-0.022331385,0.105246454,0.01900794,0.035464752,0.0758411,0.027534287,0.032894198,-0.08206826,-0.10690334,-0.005533515,-0.0101294555,-0.0016411291,0.033808284,-0.09239372,0.04027882,0.045714844,-0.012035766,-0.047551602,-0.04332144,-0.09199664,0.021866944,0.05239085,-0.0071447203,0.041888267,-0.043457694,-0.05383067,-0.09544293,0.069134496,0.018251596,-5.290692e-08,-0.05131992,-0.07626186,0.0038080546,-0.1319269,0.020759491,0.028131962,0.019125968,0.037196048,0.1069061,-0.016856216,0.04068237,0.062678225,-0.027746603,0.017893527,0.058546606,0.040385287,-0.014518437,0.018428328,-0.027954835,-0.052985616,-0.03755341,-0.061282344,-0.13394794,0.09898542,-0.035257652,-0.11986659,-0.011102178,0.040285096,-0.018648366,-0.021582285,0.04518395,0.06337857,-0.00016288878,-0.033239488,-0.04763372,0.004743917,-0.0350718,-0.0631469,-0.03833992,-0.033393607,-0.019604422,-0.036983497,-0.023986427,-0.021937888,0.008574712,-0.05125026,0.0679188,-0.007027955,-0.0032369962,0.018533858,-0.009019238,-0.044983797,-0.014171397,-0.03991559,-0.0031728277,0.0047581284,-0.0074818223,-0.00078225374,-0.011707477,-0.048846215,-0.053644817,-0.02235287,0.116507925,-0.037629556 +3.4.22.68,"The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation (epsilon-linked peptide bonds) reactions [1,2,3]. Ulp1 has several functions, including an essential role in chromosomal segregation and progression of the cell cycle through the G2/M phase of the cell cycle. Belongs in peptidase family C48.",384,1.0,-0.07453824,-0.07619583,-0.00637902,0.031496324,0.088048436,0.021086294,0.047881294,0.03102791,0.05090115,-0.029164853,0.07653717,-0.029005095,-0.019182878,-0.03971957,-0.04532335,0.009778869,-0.018920053,-0.018361503,-0.0022860111,-0.062478576,0.0758749,-0.0006088093,-0.022178935,0.000791998,0.05358449,0.01068973,0.04808087,0.02676976,0.035378423,-0.1341459,0.02771919,-0.03576852,0.010695052,0.038547605,0.022780295,0.012235451,0.0027869297,-0.041938283,-0.06318414,-0.11356354,0.046709176,-0.043688975,-0.016273916,0.059863724,0.08164879,0.011801761,-0.00791325,0.056831267,0.04505243,-0.0140544,0.048407968,0.025636569,0.09615358,0.004154895,0.0626534,0.06019796,-0.080972746,0.01839146,0.04633186,0.00648466,-0.028561298,0.0058615156,0.06326377,-0.014098196,0.03912585,-0.03648593,0.11686347,-0.032526158,0.0018054168,0.02885297,0.036764074,-0.047508903,-0.030356014,0.08036194,-0.0005109297,0.045698848,-0.07273989,-0.07206408,-0.027709771,0.02454929,-0.04775022,0.017806333,0.17658757,0.011527642,0.0041632606,0.01691339,0.020975316,-0.0027090323,-0.048190966,0.007442027,-0.025393538,-0.042628344,0.064044334,-0.0004089197,-0.06966776,0.027362179,0.028772904,0.02909988,0.03654025,-0.0017244152,-0.009805568,0.086534195,-0.020763753,-0.0591585,-0.0061949906,0.056201827,0.038526118,0.04487361,0.009236984,0.024404839,-0.065464,-0.03154348,-0.005876288,0.0117327375,-0.0073164925,0.009522867,0.060891982,0.012921243,0.03358115,0.041758724,-0.011932363,0.017667562,-0.061736736,0.12771057,-0.040970765,-0.04590698,-0.079464,2.1134169e-33,0.008132408,-0.074301116,-0.028543122,0.04724576,-0.0064151073,-0.010384214,-0.05558502,-0.08296046,-0.066519886,-0.034573004,-0.01308417,-0.008923267,0.00551111,0.0065305997,-0.025493331,-0.041636586,-0.044400435,-0.034577828,0.08871199,-0.040280495,-0.078971274,-0.0240513,-0.01389927,-0.09264822,-0.0054578134,0.041473307,-0.00050581584,-0.000859294,0.052092787,0.033353984,-0.11215667,-0.009241348,-0.119345896,0.03160934,-0.02468915,0.041789785,0.00871324,-0.025745586,-0.03036278,0.02979027,-0.037994917,0.032772314,-0.08135292,-0.11946983,0.091388516,-0.07460605,0.014486217,0.13170783,-0.03624169,0.035533603,0.034408547,-0.020874701,0.10994755,-0.06851715,0.012341957,0.071827605,-0.0071456432,-0.059376363,-0.01813444,0.03277692,0.009525441,-0.012904743,-0.0917241,0.055266842,0.034728784,0.05836123,-0.07985598,-0.025685253,-0.009151638,0.058573265,-0.0772967,-0.031592052,0.07980679,0.040002737,-0.0056856726,-0.048857298,-0.033807784,0.057260808,-0.0472921,0.09300162,-0.055898573,-0.031647068,-0.07680192,-0.01966985,-0.018025128,0.0042449213,0.021922173,-0.03184236,-0.08047115,0.027984355,0.09209822,-0.017173955,0.03894591,0.03415288,-0.021632904,-2.9359375e-33,0.0042022727,-0.018070199,0.07776823,0.007729738,0.010993617,0.046157934,0.07011996,-0.03584507,-0.0019890293,-0.005416129,0.079176456,-0.046673022,-0.041012894,-0.09964148,0.026151406,-0.020319123,0.019120378,0.09545025,0.009098619,0.044507485,0.0088423565,0.06279934,-0.018698838,0.033449072,-0.0041929465,-0.0006600377,0.00093136646,0.11846993,0.03198214,0.0064884196,-0.09393936,0.034587946,-0.008733155,-0.026899634,-0.012216369,-0.026327956,-0.09684379,0.06782385,0.0493197,-0.045616746,-0.0056701754,0.058844525,-0.1046486,0.026538514,0.03657204,0.10919871,0.039375044,0.025601482,0.022421243,-0.16224813,0.045970436,0.0073898747,-0.06596289,0.0029937145,0.024344318,0.018384472,0.069454536,0.026471265,0.038624793,0.052032676,0.008864378,0.030377144,0.06445013,0.062180128,0.043040346,-0.010382822,0.015064146,0.02209836,-0.027686292,0.04514968,0.076892234,-0.0062142243,0.102475435,0.032889638,0.0015288872,-0.024260476,-0.084375545,0.0028093106,-0.00497414,-0.03744897,-0.044165213,0.0022019565,-0.08530322,-0.034450114,0.025353441,-0.037287038,0.014182064,0.07269307,0.031812064,0.06378932,-0.045218572,0.028013444,-0.05918471,0.02007491,-0.035194173,-3.901273e-08,0.08777555,-0.026944809,0.016861223,-0.094867595,-0.010476745,0.056523647,-0.069371626,-0.037372377,-0.0019984746,-0.033242654,0.010096095,0.0824043,0.0053180866,-0.02553195,0.063774504,0.028488139,0.017750097,0.052679442,-0.0038780526,-0.014967787,-0.05079434,0.017238205,-0.050382417,0.0045688674,-0.026732901,-0.031232152,-0.036903553,0.077839814,0.06256317,-0.13206273,-0.0052938177,0.021195836,-0.010216533,-0.02810226,-0.038761772,0.03241039,-0.07445211,-0.019352024,0.015603813,0.0021707448,-0.028627073,0.01793786,-0.016168777,-0.017501371,-0.01696212,0.040003195,0.099761195,-0.03657245,-0.105786465,-0.066551104,0.0073184688,-0.047834124,-0.053807672,-0.06923578,-0.06682795,0.06671664,0.0034786772,-0.11907694,0.018121626,-0.12869851,-0.053330235,0.0013689885,0.03590627,-0.017065907 +3.4.23.52,An aspartic peptidase from Archaea but not bacteria. In peptidase family A24 (type IV prepilin peptidase family).,384,1.0,-0.036508083,-0.05682658,-0.07780033,-0.0089261485,0.01577299,-0.002695439,-0.049866956,0.044448964,0.037446525,0.0041221497,0.022960896,-0.06121511,0.00018889339,0.04720934,-0.08974384,-0.011463548,-0.0025702298,-0.075047664,0.0006417124,-0.018429957,0.0029094703,0.08561196,-0.010299456,0.056755792,-0.06252112,0.009827685,-0.00060547324,-0.09021845,0.020870164,-0.0582017,-0.0046035703,-0.08132814,0.13700837,-0.034484364,0.10201418,0.036475897,0.009197975,0.011657038,0.15547921,-0.026709465,0.05145132,0.03533078,0.076631464,-0.031250376,0.014857473,0.023503663,0.017604137,0.0446369,0.10086151,-0.0864412,-0.04166396,-0.029090066,-0.08463092,0.019616432,0.008881812,0.07857243,-0.0649171,-0.09821549,0.005438574,0.0041965833,0.038747285,0.016296187,0.023233762,-0.014594755,-0.08488085,0.0065924623,0.0064253057,0.01947262,0.035067976,0.016755449,0.02022584,-0.003775761,0.010068296,0.15015626,-0.011063319,0.036980808,0.0562903,-0.047180705,-0.07104977,-0.0411039,-0.027976584,-0.0022826423,0.04430639,0.020279028,-0.0050631315,-0.03714707,0.05245733,0.013347771,0.06446978,-0.0010301078,-0.04206435,-0.050708227,0.14254546,-0.04403386,-0.056179687,-0.031848103,0.034716208,-0.030806622,0.0669407,0.014867184,-0.0014534412,-0.008849345,-0.020114664,-0.0017754973,-0.018304024,-0.010933136,-0.048519876,0.043313455,0.10175907,0.050417818,0.005517808,-0.057261273,0.016283935,-0.0734553,-0.041608956,-0.016057687,0.008210005,-0.02296709,-0.019581966,0.00784801,0.030359656,0.012063321,0.05041549,0.009160283,-0.016163591,0.03451295,-0.09653243,2.828959e-33,-0.018401578,-0.047036275,0.10648904,0.04204094,-0.00044163142,0.018714175,-0.06781452,-0.045608405,0.02908049,-0.11405874,-0.065395296,-0.086029276,-0.056106426,0.03678354,-0.035158105,0.02897574,-0.07508049,-0.011266597,-0.03760557,0.049039453,-0.05559292,0.09730691,-0.011466833,-0.018432785,0.07773969,-0.07361388,0.05738759,-0.06343047,0.05565005,0.006500598,-0.03210708,-0.054254368,-0.11396606,-0.053913746,0.007911211,-0.025797907,-0.024908787,-0.07041259,-0.059268612,0.012261701,-0.088855565,0.08400224,-0.023484636,-0.031056108,0.0699224,-0.043195754,-0.0017511973,0.051811464,-0.017013557,0.05380873,-0.05622914,-0.0049631177,0.075578585,0.0014533008,-0.082495086,-0.029352939,0.007891793,0.08464519,0.09515878,0.05247972,0.1208145,0.04071399,-0.05971372,0.022948325,-0.038611777,0.01922159,0.022654153,0.035442416,0.06491112,0.03243581,-0.042092413,-0.01776631,-0.003276885,0.06453846,0.0042622588,-0.0862925,-0.03944994,0.03325881,-0.017658854,-0.03684154,-0.076659314,-0.030211492,0.05905447,0.04766763,-0.05892027,0.032965135,0.020570876,0.041506216,-0.02584755,-0.0030805462,-0.016302135,-0.053242613,-0.045635954,0.05308523,-0.066387035,-4.2247873e-33,0.06023934,-0.058186762,0.0065506794,-0.026704418,-0.079491675,0.04931298,0.01390309,0.04744602,0.016443787,-0.034817826,0.034176063,0.051378217,0.042458143,-0.08543668,0.04410506,0.012249079,0.032240555,0.0210418,-0.02087256,0.020541111,0.00036663856,-0.0129522225,-0.009287889,-0.02799636,0.018795509,0.029293953,-0.015543779,0.06999105,-0.056124933,-0.028092846,-0.0073845657,0.06975438,-0.015459415,-0.10587684,-0.12131231,-0.0021842273,-0.026517492,-0.08636862,-0.07309384,-0.067581125,0.022736842,0.13143471,0.055034615,0.10223695,-0.014535857,0.009453514,-0.039515764,0.07526919,0.060217075,-0.02155014,-0.022640558,-0.103146225,0.069284625,-0.0125212185,0.033747822,-0.11545192,0.0033811787,0.092905134,-0.019531986,0.023878818,-0.006103585,-0.055548884,0.03952244,0.011655048,0.031584438,0.0068507483,-0.07857359,0.004768684,0.0005279515,-0.00206958,0.032906253,0.014113295,0.00013596828,0.014932608,0.05164048,0.019606235,-0.049370505,-0.06057782,0.0114574805,-0.034881163,-0.07955025,-0.047704265,0.043561686,0.028207272,0.03580565,-0.06994519,0.033175807,0.036576554,-0.018279145,0.11276657,0.007054652,-0.0301384,0.06564811,0.033526957,0.03899532,-2.7361986e-08,0.12072589,0.013004764,0.015944583,-0.02040141,-0.06410763,-0.015842313,-0.09022581,-0.03869927,0.02782978,-0.03501935,0.029303525,0.0018180177,0.013446821,0.028106736,-0.012112766,0.07976098,-0.056913905,0.014443298,-0.010082114,0.04067714,-0.08332812,0.01650862,-0.053312056,0.0138043,0.031159127,-0.0047992566,0.03752245,-0.011991235,-0.0102309035,-0.03982455,0.010039938,0.038920894,-0.00788425,-0.09131407,0.041703414,0.045848895,-0.01105229,-0.023528297,-0.0005245375,-0.0071314317,0.028117565,-0.037813865,-0.049732648,-0.046096966,0.021793136,0.03192722,-0.048849378,0.05546987,-0.061874397,-0.027100047,0.058661427,0.037403546,0.007790949,-0.029745428,-0.087521896,-0.03250074,-0.013044307,-0.079196654,0.0042156684,-0.034629073,0.098001994,-0.023402262,0.1306208,0.08315966 +3.5.1.98,"A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation [4]. May be identical to EC 3.5.1.17, acyl-lysine deacylase. ",384,0.99999994,-0.08676883,-0.055779625,-0.07578008,-0.025653068,0.027946236,0.024238132,-0.046837382,-0.073582664,-0.056719955,-0.012836762,0.05241975,-0.0055513894,-0.032777272,-0.021970078,0.0047153337,0.046810515,-0.15469906,-0.02747437,-0.07862166,-0.08897104,0.037025906,0.061173663,-0.015202068,-0.012455034,0.043666866,-0.069486246,0.055488974,0.03264564,-0.075827666,-0.105901815,-0.0148489205,-0.08887471,0.06736728,-0.029143192,0.065782234,0.005399888,-0.07955629,-0.03318841,0.044655673,-0.000651824,0.055375375,0.0037450476,-0.054048203,0.005189242,-0.0029395523,-0.03327781,-0.06332346,-0.036407497,0.022377549,-0.0032705334,0.0069856504,0.042447485,0.00562992,0.0017402357,-0.032902945,0.014533246,-0.01154713,-0.050291125,0.06054061,-0.051746543,0.02638379,-0.045714673,0.00054592994,-0.03152014,0.028758831,-0.07160545,0.12581871,-0.07401062,0.02185801,0.010162537,-0.08880542,-0.10590763,0.0140944375,0.12942377,0.11103054,-0.06038774,-0.019274825,-0.027356349,-0.010712549,-0.04361288,-0.0019521919,-0.055609427,0.082614645,0.09439606,-0.022063727,-0.03651794,-0.027859244,-0.04596746,0.03416789,0.02084435,0.030332122,-0.060591906,0.050014175,-0.022329763,-0.020864243,0.024689853,0.09688932,0.032822873,-0.013507494,-0.012561129,0.03537127,0.035151064,-0.081871696,-0.051392384,-0.0077107144,0.037541,0.030224055,0.07081996,-0.025638107,-0.00041022315,-0.013937124,-0.045652892,0.001333898,-0.012327787,-0.0387934,0.07936921,0.009970357,-0.03809259,0.04331828,-0.042910274,0.07052985,0.009997768,0.11097556,0.08392432,-0.043171577,0.03791576,-0.15274364,2.1176272e-33,-0.0127337,0.0546479,-0.08435495,-0.010887898,0.047490474,-0.07470572,-0.08758859,0.036314707,0.021459198,-0.0576475,0.001204218,0.02451353,0.04848953,0.0049123825,-0.04607437,-0.0060046776,0.001735342,0.013237692,-0.0027071892,0.02034451,-0.07150439,0.049725723,0.012730881,-0.016216658,0.03353129,-0.0054148347,-0.019405419,0.06103178,0.027087744,0.030385567,-0.0062936633,-0.042913157,0.0179912,0.016286304,0.06633423,0.04221914,0.014968755,-0.012235619,0.05218851,0.030996457,0.0290947,0.048477285,-0.04105906,-0.07820031,0.017971637,-0.040167883,-0.04102286,0.08828662,-0.062418703,0.014364144,0.012699399,-0.044243015,0.14720777,-0.029543221,0.019166974,0.022576798,-0.040341735,-0.010777378,0.08285205,0.03534021,0.01899538,0.04670196,0.020250691,0.08406336,-0.0021933734,-0.010378045,-0.1016756,-0.021849073,-0.039782025,-0.0025247082,0.019627,0.035095796,0.10431964,0.020532481,0.03926193,-0.03896723,-0.10096092,0.08832487,-0.0844472,0.079850554,0.034334585,-0.013243854,-0.042320028,0.00512857,0.008769709,-0.030816907,0.04387121,-0.055053405,-0.010643481,0.013739413,0.011806563,-0.038385283,0.03995456,0.0022573695,0.05834614,-4.6569934e-33,0.11140062,0.017899025,0.042880535,-0.037441842,-0.011053724,0.049570367,0.07584274,0.034732234,0.0023796603,-0.0012656817,0.12503606,-0.01637866,0.0010596672,-0.120056055,0.051072735,-0.0037861369,-0.017028106,0.044914372,-0.07057408,0.0089858,0.0024343382,0.02765954,-0.04033615,0.09751137,-0.0029759626,-0.013863976,-0.112851,0.074645326,0.024426429,0.024523413,-0.08717444,0.03544376,-0.020424947,-0.050251216,-0.023175579,0.027180713,-0.040174473,0.048410136,-0.08408275,0.012128306,0.013029559,0.016338684,-0.02818396,0.042892624,0.04986727,0.097251505,0.033804845,0.09374784,-0.0073548765,-0.056895588,0.02444151,-0.05507792,0.0076153707,0.016110849,0.027320225,0.077215984,0.10030786,0.06667219,-0.018639626,0.026982166,-0.055166725,-0.0016093934,-0.0030367912,0.063000835,0.015666183,-0.026672132,-0.10316207,0.045271363,0.041956298,0.0039835717,0.02586131,-0.017386066,0.027411098,-0.012994512,-0.04395523,0.03360663,-0.041830517,-0.070239,-0.022279814,-0.035757165,-0.012629197,-0.026471103,0.00604748,0.026859056,-0.07150055,-0.04930336,0.009255381,0.012515032,-0.06806264,0.017695662,0.009744827,-0.08189729,-0.101095535,0.04013598,-0.0048403414,-3.96473e-08,0.07735274,-0.06702116,0.04798184,-0.06306424,-0.02228145,0.010175946,-0.026877016,0.09750473,0.10394261,-0.043712594,-0.016740642,0.084157415,0.01990152,-0.022234151,-0.06357048,-0.007876817,0.020770535,0.11268883,-0.010583324,-0.028639685,-0.03395676,-0.017696107,-0.012918436,0.031225389,-0.02875637,-0.046409942,-0.0038729862,0.045822334,1.2086813e-05,-0.112798855,0.016252022,-0.025935758,0.035073694,-0.030577043,-0.018269172,-0.034541212,0.0014105765,-0.10211815,0.0032599296,0.054005727,0.009658552,0.040335763,-0.12793541,0.00860263,0.011268275,-0.046918623,0.005490182,-0.014903969,-0.011776532,-0.043540835,-0.036574244,0.0035136142,0.002226706,-0.095491864,-0.011899054,0.021453047,-0.039595205,-0.0069961646,-0.003621103,0.03459043,0.05410912,0.06794842,0.10120506,-0.06810919 +4.3.1.23,"This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [1]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [3]. The enzyme is far more active with tyrosine than with phenylalanine as substrate, but the substrate specificity can be switched by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides [1,2].",384,0.9999999,-0.012194938,-0.05304684,-0.092592455,-0.117240086,0.113867685,0.049326546,-0.0092910435,0.012154347,0.0352431,0.04091756,0.045066796,-0.058297995,-0.041470114,0.06487477,-0.04606477,0.043946207,-0.09100088,-0.075282075,-0.049414657,-0.095255814,0.049608484,0.02467165,-0.042988386,-0.0043313964,-0.017392125,-0.0097044315,0.058093593,-0.04857252,-0.05319782,-0.02733503,-0.019693194,-0.09845163,0.06303115,-0.0524818,0.0142592285,0.037913244,-0.034956787,-0.10075989,0.04850683,0.060544968,0.006042668,0.02388383,0.003718106,-0.11715353,-0.049032252,0.0113587,0.0419457,-0.043534245,0.065646686,-0.009601714,-0.042684097,-0.06582933,0.046920307,-0.006827126,-0.005810473,0.008853346,-0.10892911,0.020047648,-0.032835618,0.056190845,0.022603935,0.026233295,0.041931596,-0.05550195,-0.038891166,-0.026118372,-0.017520163,-0.11685247,0.017929768,-0.06666534,-0.04244112,-0.11721087,0.001104015,0.030614296,-0.026676212,0.052389916,0.020941028,0.015244981,0.041155484,-0.011341388,-0.024435626,0.02386622,0.056151066,-0.017223587,0.027771031,0.020500258,-0.019238535,0.004520061,0.120309,-0.013237974,0.061257113,-0.012984296,-0.032855865,-0.017045379,0.01245585,0.040846743,0.021595005,0.06907277,0.016402774,-0.007988338,0.020301808,0.048041604,-0.044251654,-0.028014425,-0.070536636,0.011428489,0.06509701,0.120729014,0.002470646,-0.032402407,-0.047072403,0.00019412869,0.043307442,-0.0139145935,-0.017519949,0.06901649,0.029320387,0.0010550662,-0.017815169,0.024968777,0.049523402,0.008084531,0.12001443,0.06471491,0.0033668368,0.07145081,-0.16519429,2.8367384e-33,0.071548335,0.07682499,0.053431187,-0.012618784,-0.029947625,-0.0342285,-0.07392008,0.10226173,0.00049621396,-0.08619456,-0.096220925,-0.015161189,0.036843874,-0.077790916,-0.09077383,0.00052448636,-0.04496411,-0.04240793,0.049885284,0.06709869,0.033884823,0.08267045,-0.030997489,0.015927637,-0.0032614255,0.015097791,0.037276253,-0.07226923,0.01932114,0.015322091,-0.09132472,-0.09609286,-0.08387347,-0.035252772,-0.0034427508,-0.02473621,-0.07350646,-0.0028443614,-0.010159358,0.0388609,0.006568143,-0.0073913317,0.013523493,-0.027781311,0.04456805,0.020432627,-0.018810362,0.026820498,0.019800978,0.017302828,0.037271466,-0.03011834,0.08088197,0.030085882,-0.10859616,0.008754982,-0.0076777637,0.008457827,0.08004291,0.07145846,-0.023105647,0.028968755,-0.023519507,0.065278165,0.03606361,-0.015146729,-0.036211822,-0.0327143,0.027124073,0.08516616,-0.037619155,-0.04649609,0.07317014,0.027498001,0.033821654,-0.1316316,-0.03964583,-0.0074991537,-0.010745798,0.014066422,-0.017983815,0.037177194,0.024828734,-0.006414569,-0.0556061,-0.023127476,0.010539416,-0.041556187,-0.027491925,0.04472444,0.040989067,-0.10988561,0.016438594,0.025276596,-0.013323873,-4.0749125e-33,0.09684357,-0.12551914,0.021137137,-0.092945375,-0.049813263,0.05202848,0.07785649,0.011039975,0.009536577,-0.061579537,0.07779501,0.0060112835,0.03871639,-0.007753618,-0.022027763,0.033598002,-0.0028774808,0.057892334,0.0455519,-0.027023075,0.0011159923,0.0077663218,0.0636601,-0.009048499,0.08017835,0.008395469,-0.0023882426,0.062179036,0.05046369,0.044902824,-0.085361004,0.014823612,0.03124137,-0.043670535,-0.012598538,0.03239505,-0.05672853,-0.06841546,0.04838729,-0.00037405398,0.0046985736,-0.0052303495,0.024542239,0.043221302,-0.033247825,0.097120106,-0.10955233,0.031256497,-0.010237762,-0.04417562,-0.009319232,-0.02719285,-0.040997908,-0.035989005,-0.019489238,0.07401321,0.026488174,0.055393647,-0.06854943,0.10186466,-0.020236224,-0.05186305,0.03822221,0.05042562,0.04463159,0.05549323,-0.0018470382,0.040106498,0.03998954,0.014393102,0.01209182,-0.045244955,0.056719344,0.07932264,0.01229878,-0.047803663,-0.03149223,-0.019979702,-0.0026998848,-0.066215895,0.009306356,-0.06999219,-0.00403459,-0.041849338,-0.0030314461,-0.061332095,0.080416985,0.12014706,-0.0009230981,0.020337788,0.028455442,0.0063826083,-0.038695272,0.08974681,0.035302415,-4.903883e-08,0.039018784,-0.10471639,0.06408497,-0.056201823,-0.02092812,0.08046039,0.019424336,-0.031137468,0.01795951,-0.06319479,0.04481731,0.02948882,-0.052181985,0.024332035,-0.0047853035,0.012739525,-0.11556515,0.035228923,0.012447015,0.016906364,-0.048350684,-0.021500325,-0.12242092,-0.029966656,-0.0052869963,0.0021762801,0.026551304,0.116272844,-0.00383774,-0.050907098,-0.037495572,-0.010878868,0.018327136,0.004881958,-0.0742787,0.019156864,-0.080889024,-0.018808775,-0.062304482,0.010050879,0.01635093,0.0055463808,-0.060567167,-0.02245888,0.039566047,0.025143428,-0.04061555,0.038890105,0.015361849,0.0053514717,-0.001492646,-0.0003963496,0.036278244,0.0011235909,-0.06830318,-0.030194314,-0.0070727165,-0.07500085,0.037539974,-0.0590978,-0.0040866416,0.033647627,0.14168783,0.031133741 +4.3.1.24,"This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase) and EC 4.3.1.23 (tyrosine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [9]. The enzyme from some species is highly specific for phenylalanine [7,8].",384,1.0,-0.019126983,-0.047396563,-0.08530319,-0.110820636,0.12236407,0.047933236,0.0078574,0.005238776,0.039424125,0.033307422,0.05738633,-0.058095787,-0.059241474,0.05893941,-0.058735054,0.048588526,-0.08449648,-0.06479322,-0.056581385,-0.115339234,0.038342986,0.034954917,-0.027407413,-0.0015565981,-0.009749183,-0.0016367259,0.06191993,-0.048883934,-0.024477087,-0.030626204,-0.01890442,-0.09779453,0.053740233,-0.050108768,0.027587133,0.03166387,-0.031413082,-0.120240815,0.030250998,0.06063021,0.018754173,0.021830559,0.00816563,-0.109995656,-0.026509969,0.00068124034,0.031660516,-0.048097964,0.08447829,-0.0007024302,-0.02501989,-0.076353036,0.030587774,-0.0010104955,-0.018636415,0.0022224248,-0.101709895,0.005226714,-0.031899355,0.06697878,0.031743098,0.04857801,0.038005207,-0.0476298,-0.041738685,-0.012053266,-0.020212043,-0.10111497,0.030724052,-0.07114279,-0.050274786,-0.13267905,-0.003776753,0.028043479,-0.02406049,0.05695892,0.009535452,3.6941416e-05,0.037007432,-0.009209698,-0.023844333,0.021251667,0.06226444,-0.008328152,0.035389304,0.02605888,-0.018875867,-0.0018023398,0.11171594,-0.01804852,0.04642908,-0.018445242,-0.026518961,-0.0026667677,0.026481742,0.058418915,0.029420204,0.06280091,0.0050106295,0.0001847285,0.011545876,0.058500014,-0.048608683,-0.026023986,-0.07451776,0.019072711,0.06516125,0.119725704,-0.008370943,-0.04119157,-0.060579788,-0.013755579,0.038196277,-0.031120045,-0.0061526094,0.0748886,0.03294599,0.012512933,0.012019475,0.027799837,0.05668936,0.0100603225,0.115980096,0.060717486,-0.004846263,0.062826656,-0.16450532,1.5813988e-33,0.068389796,0.07769926,0.06228697,-0.0020860294,-0.03202572,-0.042311314,-0.07311523,0.083480045,-0.005011882,-0.08006726,-0.09372829,-0.0082978215,0.032276377,-0.073976554,-0.084146105,-0.0155505845,-0.040629234,-0.039897226,0.04909203,0.04970812,0.02977725,0.08125398,-0.025247762,0.03940827,-0.010650108,0.021651078,0.035403553,-0.055601496,0.038159695,0.017203217,-0.103511974,-0.07918553,-0.09070842,-0.04706495,-0.019939514,0.007907181,-0.07040738,-0.008079046,-0.011386938,0.07443105,0.0069078887,-0.010984985,0.024033256,-0.03287939,0.032037288,0.015959302,-0.034321684,0.027479038,0.026549183,0.010839781,0.027644826,-0.030905692,0.06760401,0.034024075,-0.112471774,0.006526634,-0.01543514,0.014550327,0.061100304,0.06401587,-0.034670074,0.022309596,-0.02697785,0.06638381,0.025171474,-0.019660294,-0.04606706,-0.03219377,0.026561422,0.0806897,-0.052631285,-0.045782503,0.07353993,0.02461358,0.0564708,-0.12990406,-0.043597966,-0.005507615,-0.023194917,0.021976482,-0.01886752,0.035146646,0.02222701,0.0005283853,-0.04832055,-0.012642108,0.00031034584,-0.03981442,-0.009887809,0.037191585,0.021551443,-0.08933164,0.033910096,0.03803103,-0.03524347,-2.9407195e-33,0.0946849,-0.116031185,0.027019449,-0.08340918,-0.05265693,0.03809236,0.07375538,0.010157174,0.015821094,-0.035811085,0.07961657,-0.00030432883,0.059455052,-0.026012884,-0.015949242,0.044295248,-0.0032522562,0.050238453,0.059001524,-0.016152604,0.016560288,-0.0033168984,0.06695583,-0.007356626,0.08085809,0.01463444,0.0065803523,0.0292836,0.045010585,0.034841053,-0.092028625,-0.009900599,0.030819187,-0.04532839,-0.028289797,0.033701915,-0.064343914,-0.05727147,0.030372187,0.005702616,-0.0108019505,0.007456853,0.029528571,0.045924887,-0.026221812,0.100694485,-0.09487176,0.045041207,-0.0010043252,-0.041780625,0.0002704954,-0.027289692,-0.043162677,-0.028859893,-0.016065767,0.07972293,0.046064798,0.062091853,-0.057320975,0.11925496,-0.010532075,-0.050767314,0.04575566,0.0373489,0.052878298,0.045674317,-0.0012947969,0.03375653,0.037054293,0.017695965,0.024080088,-0.041121196,0.04379434,0.075154625,0.020150881,-0.0614723,-0.03310218,-0.0037204053,-3.2921023e-05,-0.07672596,0.009879801,-0.077306286,0.008044097,-0.040630173,-0.0042924355,-0.07573696,0.08067039,0.12488601,0.021002721,0.026096877,0.013761245,0.019766692,-0.039280612,0.08452018,0.025448032,-4.6467342e-08,0.042547453,-0.11529116,0.051743217,-0.059433114,-0.027685253,0.0839379,0.0190234,-0.029792981,0.020840265,-0.068989314,0.052585132,0.026796477,-0.046926215,0.027111292,-0.016868945,0.0057125483,-0.095940195,0.05548181,0.017688224,0.00082824205,-0.05143458,-0.009420016,-0.1031766,-0.04112387,-0.0109142475,0.0011671343,0.03366021,0.11791326,-0.014780047,-0.042131495,-0.052698903,0.006837371,0.014933335,-0.013991618,-0.0843713,0.030757597,-0.07334267,-0.029061625,-0.077366315,0.00446479,0.0034406723,0.013717898,-0.055456728,-0.02792319,0.042466305,0.007416756,-0.023455834,0.033704836,0.009628874,-0.008614601,0.0074910996,-0.016236288,0.033634573,-0.0003526673,-0.060614336,-0.03856716,-0.004735386,-0.0880558,0.048541117,-0.08668828,-0.00869969,0.024329543,0.13955408,0.02678094 +4.3.1.25,"This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase), EC 4.3.1.23 (tyrosine ammonia-lyase) and EC 4.3.1.24 (phenylalanine ammonia-lyase). The enzyme from some monocots, including maize, and from the yeast Rhodosporidium toruloides, deaminate L-phenylalanine and L-tyrosine with similar catalytic efficiency [3]. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [4].",384,0.99999994,-0.013433199,-0.037013453,-0.085529566,-0.10013218,0.15350942,0.049326774,-0.019076806,0.0011348053,0.03675166,0.031006867,0.08272241,-0.05585859,-0.08817795,0.029353451,-0.052111767,0.057818722,-0.056566767,-0.049213417,-0.05101869,-0.12592718,0.044391032,0.027335797,-0.008689926,-0.0037178271,0.010635651,-0.016930653,0.05116123,-0.05805314,-0.045222506,-0.058978807,-0.031736854,-0.083318435,0.061547406,-0.061198045,0.012389683,0.049515016,-0.023248551,-0.11985246,0.038705934,0.049300052,0.014753953,0.0023866752,0.022914553,-0.09449404,-0.049457964,0.012401902,0.024036292,-0.016282314,0.06977128,-0.036060195,-0.014336397,-0.07403189,0.03198025,0.0044113253,-0.033576373,0.0084586255,-0.08425972,0.018060468,-0.033139896,0.07350849,0.026319163,0.046694513,0.0061575635,-0.04549777,-0.039998416,-0.01190145,-0.020274268,-0.08947844,0.02248385,-0.05549065,-0.051670603,-0.13224456,-0.003578125,0.025778119,-0.022827577,0.078465976,0.029830812,-0.00073170505,0.05785589,-0.010138021,-0.007943243,0.05406392,0.072364345,-0.020870846,0.020946058,0.0084070265,-0.02271111,0.021145195,0.12241285,-0.01578833,0.057917,-0.022883406,-0.03760539,0.020708278,0.015106852,0.0612641,0.062257044,0.047992617,0.013253769,-0.018749425,0.028399251,0.06994614,-0.044406723,-0.043092765,-0.058741026,0.047802605,0.0739374,0.112728745,0.027975468,-0.018203963,-0.047079403,0.002251042,0.01914425,-0.023828877,-0.023867637,0.033259317,0.04041152,-0.002798588,-0.010178933,0.03618973,0.06859201,0.015743513,0.09070761,0.037316408,0.0044585913,0.060156725,-0.17564903,1.869145e-33,0.055014282,0.08904736,0.008559575,-0.008748795,-0.009252466,-0.03106804,-0.04968066,0.08792069,-0.03948324,-0.063454054,-0.11267297,-0.023828648,0.021250566,-0.056871288,-0.083204344,-0.014606795,-0.02712745,-0.020143453,0.045604642,0.050469883,-0.002230277,0.07135751,-0.067292474,0.039067842,0.009715578,0.035450205,0.029239321,-0.08024805,0.037703563,0.019996645,-0.061083857,-0.059457064,-0.10564743,-0.028902188,0.00932342,-0.0027892753,-0.058240145,-0.0145587595,-0.021257536,0.058133315,-0.0029736538,0.022966813,0.03102821,-0.033783145,0.03889126,-0.011218122,-0.029751265,0.042454377,0.049628437,0.037760146,0.050207622,-0.03134898,0.058763426,0.018190082,-0.086327896,0.0114748515,-0.026674524,0.045416817,0.07023743,0.054109164,-0.033201996,0.06700419,-0.03857895,0.06910634,0.021633144,-0.021261575,-0.041211285,-0.035139866,0.018480977,0.08991217,-0.05678314,-0.06760789,0.07362834,0.037364997,0.040489424,-0.1283379,-0.032345876,-0.024756726,-0.013784524,0.014382815,0.0029945085,0.009383734,0.034649204,-0.023987118,-0.043448687,-0.0150429495,-0.027181905,-0.021124847,-0.020040812,0.03977114,0.040621508,-0.07406216,0.0154489465,0.036020923,-0.031855825,-2.5988742e-33,0.12225443,-0.09897047,0.029684337,-0.107504785,-0.0599352,0.037244204,0.06354173,-0.027049907,0.008589515,-0.039389297,0.09791307,-0.014959182,0.03849232,-0.026235051,0.0019005141,0.029887069,-0.029602667,0.05316143,0.069729514,0.006282804,-0.0060442802,0.009059887,0.041474942,-0.0013927835,0.091436796,-0.00064838276,0.016319308,0.05625165,0.041778874,-0.004043111,-0.07359454,-0.014655933,0.033709675,-0.051221885,-0.012883598,0.034417145,-0.07110221,-0.04897896,0.043849356,0.0118340105,-0.009941902,0.0042133546,0.015892548,0.03661622,-0.035066888,0.09078386,-0.120095216,0.0327041,0.013451383,-0.0058866837,0.0053009884,-0.04207984,-0.042937815,-0.0074311523,-0.005235948,0.05641834,0.03135281,0.045377888,-0.05683769,0.08756363,-0.015116302,-0.033520795,0.039606463,0.05668283,0.07742989,0.05168114,-0.027902765,0.019311506,0.033653125,0.03527462,0.038213912,-0.02837374,0.037678815,0.054592717,-0.0035139064,-0.038187116,-0.026422877,-0.01752306,-0.018439688,-0.07826259,0.03515916,-0.056610607,0.027167132,-0.032498777,-0.02130321,-0.0819696,0.061860416,0.14723851,0.017892784,0.0395135,0.04768105,-0.0099409865,-0.01975174,0.08090345,0.07003871,-4.9774474e-08,0.03898154,-0.10332529,0.036230877,-0.07822686,-0.019257043,0.065375134,0.031838678,-0.02779607,0.016555184,-0.03328831,0.031258103,0.04489463,-0.052531984,0.023896068,0.014241019,-0.011456407,-0.08613834,0.058879115,0.0077475244,0.038117852,-0.036437213,-0.0009247447,-0.13410462,-0.024390368,0.007394125,-0.01753657,0.04052273,0.113401815,0.012198404,-0.03544187,-0.044589918,0.01524791,0.022975754,-0.017006116,-0.10768492,0.031034403,-0.08195564,-0.049317103,-0.081616685,-0.004890426,0.017680587,-0.0129853925,-0.046223395,-0.04850154,0.010226478,-0.013385528,-0.027661512,0.03822461,0.017613834,0.0071449354,-0.0085667465,-0.022624737,0.015553443,-0.009579904,-0.05399277,-0.029096901,0.01612848,-0.06984575,0.04989718,-0.089299835,0.0016457405,0.023866577,0.15296966,0.012552696 +1.14.13.109,"A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine) [1], and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine) [3]. The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene.",384,1.0,-0.01651027,-0.06185694,-0.054172397,0.011150283,0.025547273,0.009634986,-0.057145216,0.002762609,0.070005774,0.055387612,0.004232003,0.026985478,-0.08469523,-0.03347761,-0.04472612,0.08714638,-0.10443736,-0.015075779,-0.027852345,-0.033739343,0.088321865,0.027217297,0.0021824967,0.05649472,0.027130459,-0.08694687,0.04424892,-0.00074141345,-0.016600361,-0.08631286,0.03468598,-0.014953761,0.06529472,0.0169708,-0.05141297,0.06094636,-0.03397835,-0.08547407,0.08614981,0.030040253,0.07403508,0.02024226,-0.06738768,-0.01539074,-0.06312174,-0.005568223,-0.00404857,0.0056090066,0.01867659,0.042190287,0.011554721,-0.02743625,-0.026849784,-0.0026411498,-0.00092431076,-0.04744729,0.061142754,0.0019700422,0.037786484,0.06260508,0.03513659,0.03430137,-0.021564575,-0.021668581,-0.09058483,-0.03239198,-0.029646052,-0.0038466188,-0.021283096,-0.113330185,-0.016280942,-0.10982663,-0.038936883,-0.032821994,-0.03123859,0.027622135,-0.057965364,0.02034259,-0.028739115,-0.038388003,0.0015491211,-0.005448644,0.0418912,0.12371955,0.02023878,-0.006392175,-0.0085276095,0.034754172,-0.031193119,-0.036816273,0.030093504,-0.016685903,-0.013588381,-0.030790763,-0.025761746,0.09931842,0.0854551,-0.07804335,-0.07812464,-0.016507616,-0.04695705,0.044464882,-0.017177017,-0.10657475,-0.07206838,-0.012259001,0.019309457,0.02778489,0.064605795,-0.041731585,0.029950377,-0.015943851,0.04956224,0.049307223,-0.06395695,0.06246094,-0.007541715,-0.0931204,-0.040854003,-0.045893952,-0.0022577909,0.0059196944,0.12961483,0.057379726,-0.08004941,0.0013965843,-0.0011206885,4.6064696e-33,0.057447627,0.038229905,-0.0882599,0.0048912256,0.012692742,-0.035814755,-0.11043921,0.04477082,-0.030232841,0.0058554686,-0.06984277,-0.077642515,0.03405854,-0.038591802,0.06564072,0.03436087,-0.009861667,-0.010867061,0.084354594,0.030631693,-0.06839675,0.008769935,-0.09294028,0.015983315,0.007311976,0.07958242,-0.0011900823,-0.009327005,0.043297816,-0.032749664,0.028398301,-0.03556201,-0.059751265,-0.054044858,-0.000113753435,-0.017036265,-0.026713353,-0.017720655,-0.0996674,0.025950152,0.02896918,0.036564652,0.03873107,-0.055917915,0.05130711,-0.011911472,-0.03720433,0.013531664,0.03333964,0.063018374,0.041468505,0.014001944,0.11785729,0.0025949283,-0.09754967,0.030065285,-0.039029956,-0.01200558,0.10315702,0.074423894,0.082345136,-0.014482629,-0.03324413,-0.025163112,-0.0589519,0.026838912,-0.089776166,0.025674457,-0.030458523,0.05965065,-0.02673157,-0.06011723,0.03833195,-0.061085608,-0.03693789,0.056558058,0.03260914,0.08207339,0.041331753,0.016338903,-0.021572128,0.019630872,0.03398777,-0.030209476,0.032504633,-0.037183274,-0.012427742,0.021137103,0.01270722,0.022322537,0.02327118,-0.00096433033,-0.048806503,0.008987853,0.036865983,-4.549748e-33,0.07413268,-0.11237031,0.036481056,-0.11951645,0.0027186116,0.054421954,-0.03599231,-0.03774904,-0.004562261,-0.044955555,0.054144617,0.010660709,-0.0065518753,-0.017890532,0.042482268,0.015821699,-0.033672094,0.1007121,-0.052284755,-0.030460743,0.03152969,0.11205859,0.0063994722,-0.049880724,0.023648819,-0.0072563365,0.021561293,0.006473935,0.031391688,0.074365966,0.04765424,0.032685686,-0.06587915,0.01009237,-0.037434414,0.07744244,-0.03221766,0.01441332,-0.035692338,0.02764263,-0.02302848,0.017932126,-0.0023834172,0.025764098,0.11305201,0.02495716,-0.13462521,-0.02331213,-0.0010439086,0.01969369,0.07030207,0.0007897834,0.0018220423,-0.00828155,0.04065192,-0.00041134097,-0.010989691,-0.0070813233,-0.019729048,-0.12581678,-0.045657776,-0.010296721,0.07086063,-0.0059413295,-0.0033793414,0.058153536,-0.07936247,0.07938639,0.016790938,-0.01359809,0.05547395,0.044641305,-0.0024124999,0.07720576,0.0005248468,0.049361113,-0.009932948,-0.08095901,-0.044194326,-0.0023429573,-0.023098268,0.049835976,-0.05315045,-0.028538484,-0.06501307,-0.047818214,0.037621185,0.094292685,0.013619711,-0.03623797,-0.0100641865,0.01923574,0.0070638107,0.07483338,0.032022566,-4.5943747e-08,-0.088937975,0.0069014626,-0.0055583445,0.03416821,0.0076587973,-0.0076014358,-0.013227637,0.0039397236,-0.017096547,-0.076954596,-0.02954797,0.08323632,-0.076102376,0.0599866,0.02804188,0.031499904,-0.0075335177,-0.00080149324,0.0352423,0.08854944,0.00085534836,0.002909837,0.013088595,0.08321587,-0.030677065,-0.160017,0.017870445,-0.016105685,0.046547674,0.005680897,0.06768387,0.10242975,-0.0031935629,0.013831353,0.01363662,-0.028212363,-0.013129295,0.051079653,-0.055457674,0.03951819,0.022357129,-0.12471952,-0.022467492,-0.054882735,-0.02138493,-0.018537164,0.029551426,0.06605374,0.030961452,0.06168028,0.055042118,-0.009919408,0.037762977,0.009441035,-0.06984151,-0.042533886,-0.020610947,-0.046243183,0.064937875,-0.1211476,0.031048512,-0.0030510214,0.21792217,-0.0078510875 +1.14.13.108,A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase [1]. Activity is induced by wounding of the plant tissue [2].,384,0.99999994,-0.053150877,0.014516059,-0.04448928,-0.0037506942,0.05971082,0.048454233,-0.08109688,0.07029867,0.023477454,0.04722852,-0.014862263,0.0030853597,-0.084288694,-0.014970515,-0.044117454,0.07269985,-0.07548498,-0.012317499,-0.024069436,-0.06065328,0.032615718,0.08218344,-0.010164652,0.04954728,-0.0076178424,-0.10215169,0.02549355,0.016771572,-0.021139612,-0.034871895,-0.03218166,-0.0033196553,0.097596556,0.04129591,-0.06875058,0.08872292,-0.024155188,-0.08575396,0.058396555,0.004041003,0.055075943,0.0042182724,-0.119285144,0.008587354,-0.042616032,-0.037479665,0.02548906,-0.021562813,0.031834368,0.0080726305,-0.012540314,-0.030205898,-0.033148453,0.0018310514,-0.025480386,-0.03365073,0.056167673,0.007394437,0.049212385,0.010109567,0.022715328,0.011675402,-0.016523523,0.026304036,-0.036620613,-0.033459213,-0.046564225,-0.0069883596,-0.04199441,-0.10450496,0.009206849,-0.09224491,-0.012542925,-0.054813582,-0.11105359,0.07845793,-0.07706703,0.01604175,0.010600921,0.0034802496,0.005959186,-0.0052820784,0.01793352,0.10754186,0.010369903,0.023751203,-4.1129162e-05,0.07020803,-0.063457526,-0.071233094,0.035794362,-0.005274402,0.0035108922,0.02092504,-0.08624863,0.0750541,0.068202406,-0.098845765,-0.06009987,-0.039456487,-0.016323244,0.074650005,0.0073556653,-0.08688877,-0.047777407,-0.017629797,0.0074829985,0.06710899,0.061963476,-0.029832697,0.0067024175,-0.03369946,0.0061530084,0.033358436,-0.029691327,0.102445856,0.005658058,-0.088493526,-0.05414878,-0.022288145,0.018206917,-0.019905759,0.070876315,0.026970478,-0.04070283,0.015435002,-0.027538978,3.461211e-33,0.10978531,0.04892537,-0.069077075,-0.0048186556,0.031760424,-0.015546477,-0.114360526,0.022912614,-0.0521706,0.037778754,-0.050102156,-0.06942591,0.06762357,-0.042664867,0.00749446,0.028145,-0.054465458,2.0604015e-05,0.08644904,0.036425292,-0.08291269,-0.034006245,-0.093524195,0.046470046,-0.023200793,0.08506088,-0.03692731,-0.0155579345,0.053143043,-0.0240002,0.015413342,-0.055214003,-0.064233,-0.06337625,0.014318431,-0.050727524,-0.023996064,-0.004623901,-0.10671576,0.036283538,-0.034490902,0.026124679,0.05914117,-0.116350904,0.081939206,-0.081058316,-0.094865344,0.0544929,0.010708858,0.0889182,0.047422014,0.004168306,0.12566829,0.040124826,-0.022278601,0.020283727,-0.016806573,0.022810787,0.07183613,0.08789554,0.13999711,-0.03636519,-0.033370882,0.054813646,-0.036247738,0.055859882,-0.11004853,0.007912624,-0.029202176,0.10525262,-0.0070068925,-0.043998092,0.03692784,-0.03544852,-0.04578508,0.031700637,0.0507015,0.09961073,0.016800394,0.051811058,0.01509398,0.02561707,0.010295837,-0.0023533518,0.044593833,-0.0049375957,-0.010354238,0.010259046,0.009263569,0.0067253853,0.055430643,-0.026090138,-0.05290865,-0.014967698,0.0090841185,-3.0193055e-33,0.09185385,-0.04994372,0.016445559,-0.13857038,0.013284396,0.07408603,-0.002148781,-0.035223912,-0.026954731,-0.03341885,0.08541163,0.027018445,0.0031920432,0.012474737,0.016508792,-0.009473722,-0.026794028,0.05967282,-0.044231664,0.026872797,0.018997306,0.062101595,0.010521059,-0.068272874,0.039415214,-0.004445174,-0.033738274,-0.0021239948,0.017563486,0.03322441,0.002217957,0.062664054,-0.11439375,0.01177689,-0.004098866,0.045588057,-0.009255901,0.023876946,0.024163045,0.00017625357,-0.052781407,0.014635494,0.021363534,0.072441585,0.08208115,0.051498957,-0.105294734,-0.028883893,-0.036928914,0.0076320684,-0.016629145,0.012769441,-0.004057372,0.021299835,0.04867174,-0.020686142,0.016772294,0.014753413,-0.03718982,-0.10247045,-0.023589045,-0.018687585,0.057820242,0.03800833,-0.004911182,0.081085265,-0.07204512,0.09171206,0.012320866,0.003319246,0.03677153,0.033581216,0.015761329,0.07011517,-0.037568465,0.04680937,0.025813702,-0.04449436,-0.03019092,0.023952896,0.0016379447,0.067400366,-0.07668292,-0.051619023,-0.07010402,-0.05204152,-0.02560156,0.07633398,0.028435465,-0.05727639,-0.046502694,0.01686136,-0.013498171,0.038429175,0.050861374,-4.161552e-08,-0.09587432,-0.025555253,-0.0021398577,-0.017968085,0.026588745,2.881833e-06,-0.021068899,0.002693304,-0.006224866,-0.040875014,-0.013788561,0.06970153,-0.03613648,0.051906746,-0.0013075524,0.015570632,0.033837922,0.014880491,0.032193698,0.029336467,-0.038210567,0.004965395,0.022395173,0.07725162,0.004525937,-0.14894235,-0.012181745,-0.029934224,0.044577826,0.01053702,0.052281782,0.10698427,0.010909219,0.009804361,0.0159176,-0.022718538,-0.01362259,0.08144861,-0.0723705,-0.0042041554,0.0062182974,-0.08917545,-0.050682083,-0.06694503,-0.0077552553,0.0041809133,0.07484442,0.0664665,0.023790661,0.034986615,0.016496366,-0.0027530647,0.050118007,-0.020943299,-0.061239626,-0.01265244,0.040239997,-0.057238083,0.041635815,-0.0761641,0.00023330696,-0.0071911,0.1844057,-0.050070804 +1.1.1.295,"The rice phytoalexin momilactone A is a diterpenoid secondary metabolite that is involved in the defense mechanism of the plant. Momilactone A is produced in response to attack by a pathogen through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme, which catalyses the last step in the biosynthesis of momilactone A, can use both NAD+ and NADP+ but activity is higher with NAD+ [1].",384,1.0,-0.060482696,-0.06371797,-0.03465385,0.03442192,0.050311204,0.111070886,-0.0735353,0.086060904,0.077869914,0.07119711,0.1469574,-0.025193898,-0.0030264547,0.01923614,-0.041312683,0.08319796,-0.047010902,0.0328928,-0.017568273,-0.020109156,0.04833556,0.08065033,0.03112839,-0.00936255,0.068589725,0.03796839,0.009001,0.025143433,0.029392011,-0.06854029,-0.06551539,-0.022797354,-0.018516934,0.012853241,-0.044262465,0.076366246,-0.04167817,-0.059559967,0.06252488,-2.7136971e-07,-0.008687303,-0.015512463,0.02222134,-0.04907655,-0.07272917,-0.026050212,0.021470966,-0.007121584,0.026726015,-0.038207885,-0.018605528,-0.035660442,-0.012996161,0.01903878,-0.016623836,-0.008933019,0.057577386,0.04122482,-0.008542172,0.019921586,0.0017064967,-0.0057541085,-0.041821703,-0.0011143734,0.03926849,-0.066180065,-0.0053333216,-0.015226453,0.0058317385,-0.05687186,-0.003864629,-0.011395297,0.00436059,0.0586409,0.048396766,0.06592602,-0.065108456,-0.013758649,0.028406056,-0.011858321,0.049000308,0.093942344,0.024886658,0.108279906,0.09161203,0.0171598,-0.045056034,0.026091691,0.091050684,0.009928078,-0.00075309526,0.0023476507,-0.011691421,0.08505834,-0.0794242,0.056690477,0.034067348,-0.046656836,-0.0500354,-0.02924492,0.029039878,0.054024287,-0.17205313,0.018591726,0.045207296,0.0022419528,-0.019102922,0.029863775,-0.0746516,0.03365019,0.041478556,-0.01602457,-0.049034808,-0.055079065,-0.05123161,0.038216047,0.021972734,-0.06292928,-0.08262684,-0.09189447,-0.01595091,-0.023424678,-0.022261543,-0.018955776,-0.025788663,-0.07686461,-0.07118592,3.8846665e-33,0.061232146,0.08926218,-0.060887776,-0.007637453,0.034334123,-0.026148204,-0.030908793,-0.024217814,0.012708027,-0.028614944,-0.13750966,-0.034633957,-0.07402644,-0.033458162,0.02778793,0.07021275,-0.021164268,-0.035408452,0.04539505,0.016905107,-0.013623958,0.06271493,-0.014588695,-0.047119167,0.002768484,-0.039393336,-0.0025993579,-0.008639231,-0.0009035678,-0.020483822,0.020220464,-0.0642824,-0.089409165,-0.055193763,0.009582471,-0.0563197,-0.05835625,-0.07299144,-0.0619101,0.054886296,-0.094395235,0.096742265,-0.04830925,-0.032764476,0.10362936,-0.0486936,-0.029350461,0.076880895,0.039214667,0.012397915,0.07326595,-0.0009789631,0.12212616,0.055673216,-0.032473166,0.06179724,0.009463639,-0.078899354,-0.030532777,0.15182163,-0.013079143,-0.05325366,0.02831867,0.08417382,-0.06942521,0.005530338,-0.11499428,-0.03526894,0.018837066,0.042099588,0.0025971883,-0.07074563,0.018921645,-0.038743448,-0.03615184,-0.022896389,-0.012123254,0.014308161,-0.019346396,-0.027475875,0.040847447,-0.01396717,0.02119234,0.013220799,-0.04440437,0.08171548,-0.03660263,-0.07024679,0.042558607,0.02376861,0.039341357,-0.043812316,0.008843479,-0.040693063,-0.0025024288,-3.8470025e-33,0.05378669,0.055277396,0.06287937,-0.11327184,-0.014552492,-0.006712726,-0.059215523,0.01005484,-0.022514585,0.024876699,0.008790692,0.0066718142,0.019647678,-0.03158433,-0.030052016,0.009909514,0.049344655,0.10190087,-0.00965986,-0.018014543,-0.07698132,0.1211439,-0.0027419499,-0.04012878,0.03973816,-0.049828034,-0.030362057,0.07622956,0.024479846,0.038093653,0.047052354,-0.024870701,-0.02242744,0.012054001,0.015059482,0.09150697,-0.026771994,-0.056745805,0.021463407,0.07882207,0.03811157,-0.034504756,0.017933026,0.058938213,-0.025990758,0.06466671,-0.103202306,0.044349197,0.03799435,-0.046821497,0.023769822,-0.016161129,0.004447773,0.035625022,-0.0030514516,0.005892736,0.03603118,0.034341045,0.023490539,-0.013878081,0.066902705,-0.031902287,-0.016152367,-0.0226388,0.020334383,0.043616395,-0.033163417,0.090728976,0.044424973,0.05149843,0.0452098,0.08465908,0.02228751,0.032261014,-0.011612525,-0.028844839,-0.07134208,-0.038215816,0.003706255,0.046997927,-0.018495267,-0.0003958402,0.014137643,-0.11932222,0.025536481,-0.02751977,0.04804617,0.087847896,-0.0012284179,0.021885442,0.0523673,-0.04233111,-0.03788149,0.058003012,0.031577617,-4.0019717e-08,0.057063837,-0.08869073,0.007649553,-0.06632512,-0.11979184,-0.06795906,0.032786623,-0.015116782,0.049290944,-0.017033573,-0.053168572,0.084411494,0.0038405764,0.024833167,-0.022655299,0.02328947,0.041112985,0.028856542,-0.051801566,-0.10616696,-0.07312498,-0.012473248,-0.034114316,0.045897815,0.0017983,-0.027144972,-0.013618192,0.045210935,0.016140955,0.012342985,0.05835833,-0.0026391896,0.037619952,-0.06630748,-0.061938114,0.06241163,-0.003386666,-0.021314055,-0.008486536,-0.04136988,-0.01929131,-0.06800787,-0.037889775,0.05346353,-0.0094600525,0.05171301,-0.0012340695,0.037367478,0.027061315,0.035078317,0.03219564,-0.071572356,0.03126772,-0.097312674,-0.08860832,0.00044139187,0.015781516,-0.0117597515,-0.024026457,-0.097542726,0.0131562,-0.008109829,0.18938527,-0.0431435 +2.2.1.9,"Requires Mg2+ for maximal activity. This enzyme is involved in the biosynthesis of vitamin K2 (menaquinone). In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. It had previously been thought that the products of the reaction were (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate (SHCHC), pyruvate and CO2 but it is now known that two separate enzymes are involved: this enzyme and EC 4.2.99.20, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. Under basic conditions, the product can spontaneously lose pyruvate to form SHCHC.",384,1.0,-0.049070198,-0.0016350113,-0.09747295,-0.012896084,0.042882476,0.04591486,-0.039938644,0.009971393,0.00043047505,0.049310304,-0.031305574,-0.017122103,0.0007635981,0.039954517,-0.027361274,0.018935392,-0.041737992,0.012324433,0.017408242,0.014407721,0.0901379,0.010170213,-0.0055881524,-0.04962444,0.010938843,-0.017410826,0.041030962,-0.0077370903,-0.037807893,0.006731031,0.0145123415,-0.057935134,0.02491392,-0.0802448,0.055761147,0.14662719,-0.062038004,-0.03959245,-0.037792556,-0.0052398792,0.018578364,0.02125522,-0.038740233,0.027463872,0.01971609,-0.028673112,0.039160613,-0.03093156,0.048729483,0.016145509,-0.056170505,-0.02260459,-0.045812517,0.03132994,0.00832606,0.008460934,-0.14035337,-0.025584878,-0.015869759,-0.014526799,-0.049104493,-0.027247516,0.0036074906,-0.024509653,0.043642364,-0.055525098,-0.013424335,-0.045497626,0.027020209,0.00086819404,-0.047392737,-0.10059715,-0.015417802,0.0071954816,-0.04139179,0.02679281,-0.041110773,-0.07513847,0.012514915,-0.023844542,0.0071283095,-0.04401122,-0.037655238,0.059880037,0.030456966,0.01752408,0.033565324,0.016809678,-0.020486804,0.12462773,0.03922131,-0.0044163903,0.09343095,0.0019006034,0.0042471616,-0.007953541,-0.014588963,0.14839417,0.004637416,-0.043987237,-0.003333433,0.05152395,-0.021399742,-0.087119,-0.026588103,-0.012391274,0.053590894,0.061038226,0.064717285,0.09474572,-0.03372688,0.060500246,-0.030194864,0.0073476746,0.028109225,0.12718596,0.024196833,-0.060152758,-0.10066425,0.018901274,-0.0066360594,-0.029503949,0.08561051,0.022169476,-0.010737477,0.01628659,-0.051307738,3.1962826e-33,-0.029058263,0.02725311,0.07808863,0.04167028,-0.072136566,0.008601077,-0.10761896,0.0029268852,0.056994896,-0.078548335,-0.08593772,-0.02849349,0.010643225,-0.018422468,-0.07465366,-0.080876045,-0.037598435,-0.06333677,0.106715195,-0.014211856,-0.009613204,0.020587623,0.003908386,0.024489412,-0.0060097678,0.0450164,0.038707193,0.027518703,0.0047036815,-0.0045457566,0.03959347,-0.081790015,-0.04538383,-0.0018810926,0.01706659,-0.013211921,-0.07275165,-0.014055192,-0.035358433,0.098549165,-0.09523088,-0.023267986,-0.06610075,0.0075257476,0.074460395,-0.0860582,-0.026405664,0.13266493,0.0033113924,-0.014299179,0.026932143,-0.024352303,0.07378808,0.018521577,-0.035915907,0.036188383,0.022608973,-0.029027976,0.032080337,0.045824792,0.04316155,0.0715328,0.041047554,0.050592203,0.006768135,-0.015745386,-0.10004654,-0.07388788,-0.072460525,0.053466186,0.0075429827,-0.05161777,0.07698171,0.017720193,0.061954837,-0.013978998,-0.06298822,0.06274612,-0.020740205,-0.043852042,0.032588616,-0.05202321,0.044156414,0.014590039,-0.07032052,-0.030697567,-0.021966496,-0.07182357,-0.03374333,0.04230852,0.017271888,-0.05442959,-0.034497924,0.0556504,0.053480107,-4.577644e-33,0.10396632,-0.04122435,0.03395404,-0.08521825,-0.0067501673,0.15475918,0.0781881,-0.034712058,-0.0011147645,-0.029000131,0.06679197,-0.030247401,0.08699898,-0.03536582,0.014656664,-0.05849677,0.018741993,0.0633511,-0.041593388,-0.04170565,0.023374785,0.06156831,-0.010941018,0.045737464,0.022836609,0.06053824,0.031776365,0.06507778,0.035179093,0.105787486,0.051678766,0.039910004,-0.08909914,0.008856579,-0.0054040356,0.045995217,-0.07127977,0.05378937,-0.013400171,0.07551481,-0.03539691,0.028512439,0.041793063,0.023727063,0.06925213,0.028491389,0.00093922165,-0.0089140525,0.0017233624,-0.061411407,0.010180236,0.02808946,-0.14219098,-6.09933e-05,0.096904345,0.10222333,-0.008756733,-0.04877481,0.0809782,-0.08135315,-0.032761257,-0.049141984,0.036015697,-0.04583157,-0.038635142,-0.011860819,0.052653093,0.02653468,0.051511034,0.024601731,0.04844225,-0.036566768,0.010725499,-0.005281812,-0.060574494,0.060563408,-0.018168611,-0.056968044,0.036196016,-0.09807391,-0.058334135,0.011837396,0.022566305,-0.041534554,-0.02098109,-0.13219042,0.025650455,0.03311026,0.0019428221,0.03531774,-0.036441937,-0.037918203,-0.09185805,0.04140341,0.047142457,-5.012719e-08,0.01169799,-0.04728249,0.07155633,0.0010597225,0.0060405093,-0.016069435,-0.06432151,-0.021200664,0.097406894,-0.0016992984,0.033768374,0.03250738,0.03878224,0.0035131504,0.016366316,0.015120002,-0.02394842,0.067952365,-0.0015683292,-0.06017808,-0.07603272,-0.07066435,-0.110671766,0.036547046,-0.0132189775,-0.09185624,0.0034506782,0.059653495,0.013970841,-0.062444318,-0.026600063,0.015727157,0.048041236,-0.045208953,-0.05978542,0.057080474,-0.031030769,0.026404154,0.035341937,-0.019919192,-0.049984176,-0.109002285,0.010584092,0.070057556,0.015828896,0.035663396,0.017345669,0.03136565,-0.05597147,0.035733614,0.037205674,0.0021038728,-0.02246808,-0.05325184,-0.035362523,0.07670803,-0.07217204,-0.08187112,0.013072441,-0.1128126,-0.021381665,0.029089393,0.056730315,-0.043711517 +1.3.7.6,"This enzyme, from a cyanophage infecting oceanic cyanobacteria of the Prochlorococcus genus, uses a four-electron reduction to carry out the reactions catalysed by EC 1.3.7.2 (15,16-dihydrobiliverdin:ferredoxin oxidoreductase) and EC 1.3.7.3 (phycoerythrobilin:ferredoxin oxidoreductase). 15,16-Dihydrobiliverdin is formed as a bound intermediate. Free 15,16-dihydrobiliverdin can also act as a substrate to form phycoerythrobilin.",384,1.0,-0.10058074,0.04314358,-0.06942688,-0.040359724,0.1391596,-0.0046840394,-0.08556199,0.021138052,-0.0014842564,0.024572447,0.048443146,-0.08400097,-0.0669555,0.06562557,-0.093375824,0.029212506,-0.10028283,-0.008417897,-0.014154319,0.04215505,-2.2767383e-05,0.0066996748,-0.02874999,0.022428727,0.0026361374,0.02396204,0.014300728,0.037719402,-0.06359512,-7.408065e-06,0.0008637045,-0.025150903,0.103276305,-0.06924342,0.057227407,0.05195857,-0.00020075537,-0.08906488,0.055932313,0.0379637,0.018380594,0.035997093,-0.0108332215,-0.0008074962,-0.057916578,-0.024321584,0.074164875,0.005939231,0.06879915,-0.029406559,-0.012128685,0.014173296,-0.050387044,0.053939745,-0.0018489711,-0.0192025,-0.05078453,-0.039105132,-0.0043862155,0.01697457,0.01578673,0.0030557073,-0.07072249,0.023625232,-0.038443796,-0.054603644,0.013866016,-0.067078084,-0.052348513,-0.061843153,-0.046363797,-0.039021924,0.04334111,0.038168192,0.019008366,0.079736166,0.072450586,-0.046287056,-0.0024413292,0.00071840093,-0.019367084,-0.031995177,-0.008177255,0.06692991,0.04014898,-0.06952142,-0.0116807055,-0.06181977,-0.005918692,0.013857269,0.046996262,0.014583246,0.004998449,-0.034149382,-0.098382145,0.08826779,-0.010415452,-0.032280874,0.017009584,0.022795588,-0.052691557,0.048553288,0.024426186,-0.12845784,0.027164428,0.04250816,-0.0020361666,0.14270364,0.02210831,0.020291483,0.030499134,-0.053162128,0.01786445,0.03433001,0.0044562663,0.09122915,-0.05812564,-0.03726224,-0.055508394,0.017723775,0.022784889,-0.053630266,0.060746238,0.028721532,-0.047766056,0.029818727,-0.06373773,5.2486455e-33,0.12538935,0.015445269,-0.015129138,-0.02719166,0.05499695,-0.017946066,-0.06962532,0.06503115,-0.004847916,-0.08262145,-0.047080927,-0.05131863,0.07543962,-0.07207341,-0.10103655,-0.06733086,-0.03171178,-0.047918487,0.025240343,0.08011935,0.060140774,0.031332813,0.012593735,0.01735071,0.06899806,0.046970524,-0.049766373,-0.011531916,0.081114054,0.0055368147,0.00032395855,-0.08944614,-0.08925873,0.008743647,0.04423809,-0.014625632,-0.011230695,-0.09123576,0.028295308,0.04547115,-0.0717227,-0.0017966976,-0.012527985,-0.018715413,0.09699738,-0.030297616,-0.0053896047,0.07746137,0.07006278,0.08375111,0.043744106,-0.043341957,0.05801019,-0.055413313,-0.06724941,0.018675495,-0.031344373,0.011701346,0.0766396,0.027692297,0.006446327,0.082701944,0.013867138,-0.009289222,0.043881793,0.013796082,-0.027648034,-0.053730406,-0.0018632261,0.003705998,-0.112279154,0.018804044,0.08892569,-0.0077462066,0.086432904,-0.028807426,-0.04617008,-0.017395131,0.062079377,-0.026687868,-0.029987296,0.01388519,0.007033916,0.007951417,-0.021409824,0.016670661,-0.053967938,-0.009303493,0.03836876,0.0041837874,0.03583004,-0.0782569,-0.021808024,-0.052382674,-0.021085212,-5.4068486e-33,0.09622302,-0.08911911,0.0025903017,-0.02749713,-0.032876167,0.045774095,0.00045216436,-0.015251055,-0.028234037,-0.022113217,0.10476806,-0.032044902,0.024362007,-0.01232642,0.009323832,0.041793052,-0.04165702,0.05526671,-0.03045024,0.02522898,0.033014406,0.011096865,0.025820883,-0.019219138,0.072467856,-0.042915348,-0.0006730885,0.0043316027,0.07578647,0.026978055,-0.10113869,0.03739666,-0.05423112,-0.062598936,-0.049672432,0.10227449,-0.11201474,-0.0021238849,0.043740604,0.05489174,-0.0055746534,-0.055733446,-0.033149704,0.027476769,-0.004284886,0.052462135,-0.053525206,0.049811285,0.06983932,0.026887298,-0.020456433,0.05322668,-0.080191284,0.009793235,-0.011987346,0.07963269,0.081447594,0.04325024,-0.018061835,-0.021694126,-0.033101298,-0.092642285,0.08051556,0.035925906,0.04233958,0.09071103,-0.0043559573,0.085550666,0.055502404,0.0147365965,0.040643305,0.0020987836,0.114258274,-0.032923833,0.026001656,-0.009875637,0.020221593,-0.08931913,-0.055095,0.036480628,0.017599292,0.0018735494,0.014432849,-0.06513784,-0.04302595,-0.07029423,0.066850945,0.011435086,-0.066760466,0.012069985,0.018177575,0.020097537,0.009938981,0.056047108,0.044281248,-4.0943945e-08,0.025725018,0.0004742166,0.050953273,-0.040876973,0.064657845,0.017809654,0.01718917,-0.013792266,0.005826889,-0.03874696,0.055142134,0.066360414,-0.007390483,-0.043474145,0.071251705,0.04528664,-0.030561967,-0.024317829,-0.03867542,0.032934994,-0.028448468,-0.042377733,-0.15219955,0.042376168,-0.01171357,-0.07053448,0.018998679,0.007864178,-0.061174132,-0.056391448,0.0026348599,0.036679212,-0.034897894,-0.032166734,-0.018038224,-0.019398134,-0.08730362,-0.01220885,-0.052262064,0.016692242,-0.026179986,0.014596479,-0.092564985,0.022414126,0.03948347,0.053986814,0.003353854,0.051226564,-0.0038402192,0.069012076,0.02133497,-0.021881558,0.0040057874,-0.05258174,-0.054927833,0.09810764,0.011958642,-0.07322014,-0.11819592,0.015190656,-0.0592805,-0.002407846,0.17601368,-0.038740966 +1.3.99.24,"The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2].",384,1.0,-0.065006085,0.021716962,-0.032956976,-0.056005046,-0.017812325,0.047737602,-0.038494375,0.086412705,0.020240976,0.018422961,0.003548185,-0.046442755,0.04513342,0.027412264,-0.055038735,0.056400042,-0.08124751,-0.015897851,-0.009106468,-0.013474548,-0.094916396,0.06840682,0.015852304,0.025372216,0.028503839,-0.010344637,0.030424673,0.05168454,-0.012890298,-0.024641959,0.09664696,-0.031639706,0.03715208,-0.01650462,0.06709416,-0.05259134,-0.038055673,-0.05265523,0.107533745,0.069203064,0.009112703,0.054714784,-0.048269153,-0.019867806,0.014430377,-0.06227054,-0.0071340413,0.022865266,0.04745905,0.021683922,0.007401133,0.02823265,-0.077167034,0.055398107,-0.007731612,0.009638635,-0.042757425,0.023498394,-0.05396683,0.01346378,0.14567427,-0.008430198,0.09336582,0.04721036,-0.069269255,-0.015972933,0.026057282,-0.06524563,0.015419105,-0.051361833,-0.03660602,-0.10931426,0.00021108458,0.0051789912,-0.0013527469,-0.008710895,0.02498521,-0.027975198,-0.05690215,-0.10307639,0.0684603,-0.06264388,0.055520307,0.020368546,0.009258214,-0.023684792,0.07498535,0.0023036473,0.11267153,0.026849952,0.05669241,0.014314205,-0.032993857,0.0037244214,0.034876596,0.0243623,-0.010072466,0.13204952,-0.032580268,-0.0025517503,0.022456434,0.03169723,-0.06942549,-0.093336545,0.055450592,-0.049826827,0.1021948,0.056242596,-0.054362345,-0.071186095,0.0025871915,-0.086615935,0.060355738,-0.024427313,0.0076498063,0.058976326,0.10907361,0.028314551,0.0018075072,-0.0011492459,0.07724835,-0.002132381,0.05522202,-0.042543225,-0.010976043,0.07316687,-0.060719386,-1.0026169e-33,0.029290505,0.039591257,0.039700016,0.05088915,0.022122,0.0068625477,-0.07682506,0.06168322,-0.09017907,-0.06419651,-0.09306495,-0.009142936,0.06995882,0.029780213,-0.06784891,-0.04497983,-0.0012154509,0.049306918,-0.014675159,-0.07860083,0.04044978,-0.02718019,-0.05331091,-0.017446436,-0.007915573,0.10363575,0.0020976674,0.07061663,0.09645391,-0.030184148,-0.0683803,-0.03380046,-0.107375145,-0.024062196,-0.027091984,-0.005310838,-0.025760144,-0.0012962801,0.06544645,0.030154053,0.009795591,0.026849044,0.009908736,-0.07527326,0.018110458,-0.009330395,-0.087085225,0.078593,0.0824027,-0.0024078293,0.0756342,-0.09516316,0.032431643,0.01990654,-0.013393355,-0.018299915,-0.024989597,0.05763992,0.05881012,0.025389124,0.014588557,0.022398233,-0.07898498,0.007866382,0.06848463,-0.05800659,-0.028785476,0.0227148,-0.072763965,0.002889166,-0.106880926,-0.026848871,0.08017731,0.062203154,0.04348795,-0.061102506,-0.09734498,-0.07711927,0.065533996,0.061847735,-0.06449072,0.011794752,-0.019280808,-0.008923883,0.008063368,-0.06364842,-0.07509842,0.038094964,0.015929533,0.09619367,-0.011346026,-0.0061334483,-0.09360651,0.03709076,0.011482702,-1.8284027e-33,0.04664967,-0.030303044,-0.015818484,-0.024629552,-0.044446707,0.07886509,-0.00742184,0.0008884943,0.070189886,0.050166782,0.15936512,-0.02888408,0.048385933,-0.032201387,0.027308356,-0.05486303,-0.0231953,0.013981746,-0.01301209,-0.022702392,0.023110844,-0.032888662,-0.07367835,0.011080553,-0.023347938,0.029493637,0.08207922,0.011006273,0.057110842,0.06765073,-0.054693885,-0.06832774,-0.0842448,0.060817998,-0.028809577,0.12980673,0.010819904,-0.04337576,-0.024228847,-0.041293375,-0.044023473,-0.017090656,-0.020767508,0.08152918,0.061691348,-0.008182007,-0.00132289,0.014269714,-0.043091394,-0.007528074,0.02263531,-0.00042858085,-0.03125825,-0.001885247,0.0033922282,0.008249255,-0.029212251,-0.026288258,0.027601415,-0.0052838568,0.00051033084,0.011760723,0.02213253,-0.015871216,-0.040627316,0.050180335,-0.07562269,0.09082946,0.03885617,-0.11418161,0.03611226,-0.016612742,-0.06593234,0.02072614,-0.09241987,-0.009472027,0.022122025,-0.072139345,0.04132551,-0.07915804,-0.005792914,-0.03818014,0.038125508,0.036083575,-0.06288454,-0.057293165,0.020228807,0.058875937,-0.025268558,0.001932205,-0.0308575,0.032127522,-0.0024714763,0.0856212,-0.026292644,-3.4642454e-08,0.020156132,-0.050067715,0.11188475,-0.040062048,-0.029898996,-0.012359035,-0.024938475,-0.016514901,0.059141755,-0.08471669,-0.0010738393,0.069188945,-0.018104507,0.04825645,-0.012515157,0.044600148,-0.06025515,0.020661712,8.390812e-05,0.033556644,-0.04268849,-0.02691782,-0.07651562,-0.050751112,0.03215322,-0.054260112,-0.004232135,0.007857225,-0.0620259,-0.03205457,0.040148422,-0.026833523,-0.04479816,0.009777212,-0.044021796,-0.042676717,-0.048054397,-0.07657497,0.019696776,-0.028605517,0.05871143,-0.06289023,-0.11583725,-0.009940645,0.05851344,-0.024176998,-0.053677928,-0.021528032,-0.07232143,-0.05831501,0.018305205,0.010076657,0.0495456,-0.041512493,-0.0131166,0.057965457,-0.009129093,-0.013284423,0.014270319,-0.032187436,-0.06923488,0.014185568,0.12493329,0.006546326 +2.3.1.185,This enzyme exhibits absolute specificity for the 3alpha configuration found in tropine (tropan-3alpha-ol). Pseudotropine (tropan-3beta-ol) is not a substrate [3]. (E)-2-methylcrotonoyl-CoA (tigloyl-CoA) and acetyl-CoA are the best substrates.,384,1.0,-0.051641945,-0.12756662,-0.17167729,-0.055481903,0.009630637,0.0032563366,-0.027946264,0.03432781,0.033849664,-0.022987451,0.058065932,-0.048757434,-0.08346399,0.03833435,0.013477731,-0.011636379,-0.030033307,-0.071000986,0.11499241,-0.006649721,0.07539039,0.0031575582,0.019073816,0.0058219824,0.019000856,0.022939816,0.022533705,0.03159847,0.06104638,-0.037343677,-0.10281622,0.054325234,0.025579713,-0.0026171636,0.06173804,0.08177253,-0.14002842,-0.023838004,0.021046747,0.047462128,0.085815415,-0.03045375,-0.018697415,-0.06335284,-0.033630926,-0.091852635,-0.04501012,0.05334334,0.016985971,0.035059333,-0.038809843,-0.03225678,0.01584451,0.076050356,-0.08132108,0.03805361,-0.034303457,0.05572496,-0.009793525,0.074998915,0.021770738,0.06556654,-0.052299753,-0.020900736,0.073126644,0.023973955,-0.003956816,-0.031970985,0.048554678,0.016007064,-0.07113058,-0.013915194,0.018109493,0.067358725,0.013969249,-0.029140739,0.01906871,-0.02331848,-0.07591948,-0.04254576,-0.0062700235,0.0017151475,0.050946612,0.09098006,0.052721914,0.018757364,-0.05719555,0.0441377,-0.0022273923,0.02399949,0.06980144,0.030602694,-0.05424995,-0.07343201,-0.026293352,0.118694,0.004788373,-0.047962092,0.023249596,-0.0031508482,0.083648145,0.05173155,-0.044290096,-0.014945338,-0.042385764,0.03900562,0.024117395,0.006016713,0.010232099,0.0025135055,-0.027039513,0.017344626,0.075512566,-0.025876774,-0.055282123,0.08647203,-0.04924425,-0.06452639,0.0632618,0.018634198,-0.03704514,-0.010344715,0.020112969,0.06512496,0.043554265,0.048200045,-0.09210068,2.2307298e-33,0.07011907,0.032726806,0.024559127,-0.066243924,-0.025534047,0.016261205,-0.09648387,-0.033761512,-0.042105872,0.011528753,-0.053332172,-0.057831634,0.0087307,0.054057084,0.027409814,-0.03052505,-0.034121122,0.098044366,0.060911465,-0.024432426,0.011287453,0.070684046,-0.086017884,0.0056449836,-0.012732057,0.054650497,-0.03803342,0.089883775,0.0335531,0.014809706,0.057938952,-0.024082584,-0.031354524,-0.0123171555,0.031645615,-0.057003785,-0.053051762,-0.028554494,-0.059829287,0.12980531,0.123879746,0.04069185,0.07788671,0.031180935,0.03291353,-0.07666234,0.003178714,0.045898423,0.013024489,0.057700984,0.062009264,-0.048103634,0.03125257,0.017295955,-0.05365877,0.05204805,-0.040922265,-0.021367911,0.081454456,0.04111758,0.023175994,-0.016978582,-0.023986988,-0.04511367,-0.048297465,0.009974228,-0.07104534,-0.098339364,0.0003177414,0.06192823,-0.08182073,-0.00460477,0.0303716,0.060183913,0.117229156,-0.029105587,-0.032452967,0.05763462,-0.0016779052,-0.05465306,-0.042035516,-0.0009191658,0.015220475,-0.035913706,-0.071408674,-0.030987317,0.060786933,-0.0802128,-0.05237895,0.0136543345,0.0071528214,-0.033587568,-0.031599645,0.022643369,-0.024224184,-2.6499154e-33,0.016387865,-0.07595027,0.05044605,-0.12533092,-0.10142615,0.040774073,-0.00917846,-0.07687405,0.052967757,-0.019203547,0.15183295,0.042284418,0.003876619,-0.056861166,0.044379145,0.055677723,-0.0075882054,-0.0019869474,-0.0037691572,-0.052309882,0.0021099686,0.007913321,0.03915248,0.09519695,0.05074041,-0.02411493,0.00088708324,0.048144817,0.03365608,0.09263619,-0.025742423,-0.020510323,-0.04244094,0.05507946,-0.03171258,0.004751111,-0.07876739,-0.028178884,-0.045391865,0.018059392,0.024444053,0.036266908,0.007088243,0.02670724,-0.037654486,0.044201117,-0.035839193,-0.06457143,-0.023810659,-0.04038336,-0.0077531193,-0.0010994375,0.047120564,-0.015613447,0.06753134,0.041934717,-0.042119335,-0.01855564,-0.054032803,-0.05909089,0.0130557185,0.026491765,-0.014002217,-0.024556827,0.10993328,0.040121503,-0.008473687,0.076517254,0.004185545,0.008782041,0.009207792,0.0358043,0.010809272,0.059459355,-0.050673332,-0.061740596,-0.03438126,0.014009067,0.019978037,-0.028872753,0.0015595594,0.03652244,-0.076924935,-0.10436091,-0.10671465,-0.00024616878,0.02659283,0.09697804,0.06473553,0.044006787,0.03950446,-0.0034813734,-0.016290767,0.014071996,0.04919552,-4.019687e-08,0.034368698,-0.078778446,-0.017144285,0.002267815,-0.0348842,0.026665589,-0.019030457,-0.07740545,-0.02731293,0.0025936263,-0.012349979,0.012282992,0.020907974,-0.029914774,0.043905098,-0.01575785,-0.055595506,0.03506032,-0.017041262,-0.028409638,-0.056118492,0.024462556,-0.09148327,-0.0031541344,0.07969542,0.0019650264,0.0017083497,0.032371208,0.044178568,0.059147652,-0.023336876,-0.0037971535,-0.008024066,-0.022446886,-0.05584079,0.006345953,-0.04505111,-0.01759685,-0.09756764,0.07395221,0.08090056,-0.035054296,-0.05164152,-0.03624349,-0.039582703,0.0054639545,0.07404775,0.01690842,0.050916836,-0.046385873,-0.04233052,-0.020323556,0.0022864423,-0.021830961,-0.057034567,-0.05994053,-0.10760745,-0.052852903,-0.05774244,-0.046285544,-0.027849989,0.053636298,0.13258992,0.0369072 +2.3.1.186,"This enzyme exhibits absolute specificity for the exo/3beta configuration found in pseudotropine as tropine (tropan-3alpha-ol; see EC 2.3.1.185, tropine acyltransferase) and nortropine are not substrates [1]. Acts on a wide range of aliphatic acyl-CoA derivatives, including acetyl-CoA, beta-methylcrotonyl-CoA and tigloyl-CoA [1].",384,0.99999994,-0.064402066,-0.117278405,-0.19914399,-0.001725725,0.026006367,-0.0048868475,-0.023303904,0.046345856,0.071042456,-0.03934352,0.084822856,-0.054838795,-0.108996086,0.029944409,0.009589597,0.0075567835,-0.0297447,-0.06959546,0.076962136,0.0064651812,0.031994715,0.02419741,0.0154949995,-0.010758298,0.03965939,-0.035509802,0.010351864,0.021506764,0.0480467,-0.056470927,-0.07369673,0.04943624,0.028180826,-0.007758949,0.06410824,0.03880774,-0.088414684,-0.046287555,0.02020036,0.019446403,0.082881264,-0.0060818447,-0.05843454,-0.008196707,-0.020149995,-0.11201508,-0.054674257,0.07855911,0.014019177,0.009934382,-0.012074077,-0.033657517,-0.019396175,0.035773758,-0.07935014,0.016530056,-0.050898097,-0.004927115,-0.008596209,0.08282969,0.008477747,0.055986855,-0.022289483,0.014349376,0.013565554,0.031934507,0.0531179,-0.041131854,0.061539516,-0.017668156,-0.10651104,-0.040986445,0.01033242,0.04529347,0.009867035,-0.021579608,-0.0012451807,-0.010243029,-0.06785473,-0.0597933,0.009360416,0.014461073,0.06375201,0.03183159,0.050429665,-0.0033514076,-0.02866864,0.053383954,-0.025681678,0.06158575,0.027677713,0.0038310778,-0.052702002,-0.071991414,-8.2573446e-05,0.11508244,0.039452862,-0.047249623,0.02851664,-0.0059756036,0.05090282,0.06983062,-0.03314903,-0.037886195,-0.0421928,0.02782225,0.058016513,0.016001279,0.015015651,-0.009983834,-0.06296146,-0.024743976,0.08093349,-0.040428557,-0.07253367,0.06528557,-0.06469152,-0.05896597,0.024694698,0.04720054,-0.03737116,-0.010399906,-0.011929231,0.08257023,0.069863945,0.08557785,-0.069376804,3.7545065e-33,0.09139155,0.04184452,0.046902265,-0.04974893,0.032930497,0.015771696,-0.110278666,0.009647639,-0.0565167,0.038420618,-0.020846315,-0.057871535,0.040147953,0.04028394,0.071327314,-0.0068419543,-0.045525834,0.062164113,0.09580994,0.0010564202,0.004678871,0.04995396,-0.07542567,0.004475638,-0.03423164,0.089783445,-0.058814194,0.09961459,0.03540755,-0.004653546,0.038577583,0.0012336745,-0.02706312,-0.012466262,0.049768142,-0.054622777,-0.0655072,-0.014604925,-0.02280075,0.118109606,0.13944934,0.05882584,0.02075423,0.0048429496,0.013307282,-0.08319755,0.0047052125,0.062750876,0.05282048,0.0719379,0.04512904,-0.017901804,0.046613764,0.051331803,-0.028724026,0.050269112,-0.09721508,-0.010136459,0.058230557,-0.013186728,0.02746698,0.01286835,-0.009936174,-0.08092855,-0.08787754,-0.010924916,-0.094519414,-0.052316904,-0.016430147,0.04438707,-0.062214937,-0.0018989244,0.03849825,0.072146334,0.120976485,-0.003846409,-0.06405195,0.03772851,0.032509267,-0.043481536,-0.023272974,0.013312465,0.04438113,-0.04704629,-0.027503818,-0.006652309,0.021802004,-0.054494586,-0.04680451,0.0042364546,0.010183059,-0.009689918,-0.057933107,-0.006007978,0.027544662,-4.7682397e-33,0.051167674,-0.06915381,0.019978847,-0.19158047,-0.056037687,0.026097015,-0.025768397,-0.071579196,0.07202614,-0.006540978,0.12036762,0.062917866,0.05813897,-0.09392963,0.06756618,0.029364837,-0.020652547,0.014163979,0.0035777106,-0.0833398,-0.00278127,-0.016123068,0.015287992,0.05854457,0.059344467,-0.0014587594,-0.034381356,0.06581511,0.018843794,0.08853832,-0.006637466,0.00031227595,-0.060682643,0.019494573,-0.025718607,-0.022974584,-0.10314879,0.00034596788,-0.047516394,0.019203274,0.02439041,0.046135824,0.04322432,0.011954027,0.040893372,0.060504787,-0.015722608,-0.066710845,-0.023898054,-0.07302287,-0.0058478187,0.025987899,-0.012335571,-0.005200087,0.052937716,0.075430155,-0.024438199,-0.02528974,-0.05713589,-0.0672014,0.019014433,0.016698489,-0.011299503,-0.022160692,0.085766174,0.024272557,0.04972689,0.074300274,0.011777169,0.0021355823,0.039894,0.020062497,-0.04434586,0.04766816,-0.039741155,-0.055398166,-0.027352901,-0.03696888,-0.034542963,-0.06136309,-0.009921189,0.014587931,-0.065076634,-0.091837384,-0.1186933,-0.01174528,-0.015709007,0.04883429,0.065878734,0.055315312,0.026057448,-0.0045411964,-0.0037494593,-0.021458726,0.01259332,-4.5146077e-08,0.027148556,-0.047795624,-0.0008910231,0.025389329,-0.046397,0.03245021,-0.01909891,-0.076562084,-0.030246628,-0.0139044095,0.02229629,0.020556273,0.029681496,-0.017323105,0.060130287,-0.023472305,-0.038252786,0.06923536,-0.00955268,-0.03331407,-0.0942473,0.026638621,-0.056884993,0.020009974,0.02293669,-0.014792775,0.019851262,-0.023025535,0.051205367,0.00618511,-0.0027928192,0.012466393,0.022541502,-0.021342156,-0.042541686,-0.00769327,0.00399274,-0.022747334,-0.09997879,0.074172355,0.08321005,-0.048645746,-0.054401394,-0.001628805,-0.01751111,0.007813292,0.0886458,0.0048464797,0.07046886,-0.05376015,0.022092752,-0.010660862,-0.042801388,-0.01632044,-0.04195819,-0.056099977,-0.10004427,-0.03965651,-0.025497092,-0.038891334,-0.043223858,0.029535288,0.13314943,0.017168926 +2.6.1.86,"Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. In Streptomyces globisporus, the sequential action of this enzyme and EC 1.3.8.16, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity [3,4].",384,1.0,-0.08717896,0.0144689735,-0.13605703,-0.02551318,0.06019353,0.014520262,-0.037942264,0.0627137,-0.00043298802,0.033440843,-0.028108163,-0.0066433754,0.05753985,0.051330548,-0.09170462,0.016302116,-0.018528927,-0.0143103525,0.037605792,0.02197254,0.05207901,0.0805187,0.016394885,-1.2170601e-06,0.018443318,0.050256807,0.055556577,0.0036774955,-0.033115752,0.013585918,0.01702634,-0.0462713,0.09093803,-0.06021113,0.049206622,0.046805326,-0.05915914,0.019038703,0.11721551,0.033215057,-0.011694067,0.017418563,-0.05149269,-0.016513273,-0.023868589,-0.03801079,0.048409626,0.044796612,0.026349328,-7.745095e-05,-0.085655324,0.024834774,-0.07108702,0.062633686,-0.025418175,-0.020147745,-0.06445321,0.036115404,-0.043889016,0.0005950713,0.045928948,-0.036266316,0.0065868273,-0.011338669,-0.021259189,-0.026721988,-0.013535368,-0.068962194,0.070363276,-0.013806831,-0.032243595,-0.009589641,-0.015731692,0.03278576,-0.018218663,0.056272224,0.05922896,-0.0022363018,-0.03002137,-0.0733973,0.06629564,-0.0603114,0.08062173,0.070803694,0.054363694,-0.0284303,0.024836043,0.089039765,0.14216015,0.059177805,0.07843709,0.03745193,-0.06390673,0.05805867,-0.016787397,0.023152925,-0.029907653,0.041616797,-0.0109930765,-0.037895914,0.0010692797,0.0103421975,-0.042610493,-0.021276888,-0.013742573,-0.047320627,0.062789515,0.03167295,-0.002096468,-0.03661666,-0.0056568882,-0.036037832,0.043914787,-0.0012086751,0.012548505,0.075269304,0.077947125,-0.061358523,-0.115945145,-0.05580923,0.05045858,-0.000480128,0.035215415,0.017995752,-0.0013601263,0.034800593,-0.15164502,2.1170675e-33,0.021921268,0.06480962,0.0136016235,0.0206129,-0.04565478,0.012279531,-0.09151192,0.024941599,0.005148351,-0.051359568,-0.05209608,-0.099424675,0.030690916,0.041077346,-0.043379117,-0.00829355,-0.008923894,-0.0065185386,0.06831765,-0.032801475,0.016260218,-0.005223965,-0.062487513,-0.023031823,0.020239012,0.13889565,0.016568866,0.019292427,0.06528571,-0.028121367,0.064165995,-0.10504294,-0.14583407,-0.0047868253,0.036669847,-0.0040652053,-0.09445212,-0.043760978,-0.0031571852,0.021510301,-0.09796665,0.036763888,-0.024457403,0.032619588,0.07720023,-0.011386515,-0.05643626,0.1039959,0.051062513,0.060953803,0.059168898,-0.040036798,0.038818587,0.050261382,-0.111700624,-0.0018510164,-0.008156271,0.03835911,0.090358,0.06242712,0.035890963,0.019411894,-0.03351235,0.058951847,0.0075033396,-0.013823211,-0.043317426,-0.03797375,0.0077508194,0.06282762,-0.059205987,-0.042444203,0.05739349,0.067606345,-0.03064015,-0.01691551,-0.034113087,-0.049476735,0.038886417,0.038072057,0.015857494,-0.03840061,-0.036178615,0.0018524165,-0.08397052,0.007077487,-0.020419544,-0.053280246,-0.0013624186,0.010117846,0.042370204,-0.048472974,-0.063271485,0.049100805,0.0135019105,-3.677102e-33,0.103779666,-0.06655321,0.05555724,-0.054420818,-0.07878551,0.08125595,0.012916144,-0.052618913,0.040849928,-0.027644293,0.09201182,-0.048502453,0.019364726,-0.021571897,0.021154447,-0.050050054,0.018689219,0.035536915,0.015216127,-0.028253714,0.03621935,0.10785605,-0.024316574,-0.016961493,0.013986107,0.024253666,0.03369857,0.055015683,0.015902577,0.08687947,0.05469493,0.021317173,-0.08814488,-0.0476947,0.011938653,0.13552313,-0.056795765,-0.0219279,0.01777729,0.004563832,0.04191669,0.015065202,0.04263594,0.05616506,0.03955201,0.050657365,-0.061071385,0.048519216,0.0044599897,-0.07304825,-0.011587373,0.04067793,-0.05174896,-0.05308303,0.0984755,-0.018514264,-0.035885822,-0.040214255,-0.0070884186,-0.053175654,-0.0004425748,-0.045296796,0.009803542,-0.050678033,-0.03357772,0.041016523,0.04565837,0.06426549,0.10534185,0.0015091703,0.04814718,-0.0162298,-0.021558536,0.053822283,-0.13412386,0.024001097,0.017306801,-0.0114747295,0.03240602,-0.033005923,0.016160928,-0.0064291605,0.08200092,-0.024193244,-0.05802402,-0.06775181,-0.008733763,0.07213018,-0.0006020075,0.018500542,-0.015352792,-0.026259994,0.060841583,0.06391394,-0.028567035,-4.660148e-08,0.015991753,-0.08878228,0.08014461,-0.08372633,0.0026083563,-0.020803742,-0.06440813,-0.05059829,0.03230991,-0.077764064,-0.010013819,-0.03862198,0.01541644,0.02378223,-0.011950493,0.014445049,-0.07575798,-0.004623169,-0.024903955,-0.022188505,-0.07218993,-0.058045942,-0.18359928,-0.006096753,0.056248926,-0.062022746,0.006059218,-0.040434167,-0.030660952,-0.012141075,0.03122383,0.0046873824,0.02040718,0.008155612,-0.081675954,-0.012550001,-0.048503567,-0.012705102,0.0069988673,-0.10366233,0.04808759,-0.05002371,-0.0046443953,0.019477952,-0.0027277297,0.014411901,-0.010891275,-0.09204812,-0.04754504,-0.06373616,0.052649647,0.029322663,0.0469484,0.0040608943,-0.06789467,0.059372675,-0.032701157,-0.037162565,-0.042915545,-0.06192882,-0.029135756,-0.0123929065,0.09052526,-0.021453973 +2.7.1.161,"This archaeal enzyme differs from EC 2.7.1.26, riboflavin kinase, in using CTP as the donor nucleotide. UTP, but not ATP or GTP, can also act as a phosphate donor but it is at least an order of magnitude less efficient than CTP.",384,0.99999994,-0.09136662,-0.047550023,-0.015961315,-0.10634408,0.013643682,-0.04361632,-0.0749157,0.025430357,0.042486914,-0.0038742977,-0.015570417,-0.039788187,-0.08499186,0.07174464,-0.042692475,-0.04399085,-0.0100727985,0.017460994,0.08059093,0.0029325713,-0.008032067,0.027932363,-0.019148536,-0.02941763,0.055080663,0.039766315,0.08036495,0.00955156,-0.0073400023,-0.071683876,-0.10036336,-0.05673611,-0.009439875,-0.067146234,0.021048645,0.1766112,-0.08342671,-0.09221624,-0.033923414,-0.018310959,0.09019351,-0.0017009833,0.039811153,0.030891826,-0.008392212,0.024730455,0.03793017,0.051684435,-0.0058170883,-0.07025039,-0.0005669476,-0.0056285034,-0.03307569,-0.05118747,-0.0022132623,0.07438688,-0.04606588,-0.04505181,-0.024324607,-0.03212044,-0.02176553,-0.014416612,0.03179385,-0.0030187038,0.07922367,-0.023551404,0.07967911,-0.06554429,0.02850675,-0.055111248,-0.07110222,-0.009212825,0.05058433,0.086260624,-0.032782085,0.07343696,-0.032268435,0.003306383,0.015210979,-0.023989521,0.04971619,0.007643855,-0.046887316,-0.038865425,0.061975703,-0.033004966,-0.015359797,0.058671843,-0.0038618527,0.043711312,0.061632413,0.046355356,0.10328822,-0.05893734,-0.07679737,0.0038622916,-0.019036666,0.086409405,-0.025563842,-0.056046672,-0.004588512,0.13723445,0.002311152,-0.060253102,0.014872469,-0.023268003,-0.033121563,0.018409671,0.039094254,0.019733375,-0.0070411726,0.049776483,0.015256269,-0.019798921,0.07595531,0.08030036,-0.08454222,-0.1059575,-0.029434947,0.06745289,-0.05848354,-0.14072755,-0.013190506,0.07670233,-0.058826104,0.028447412,-0.088002205,6.5291934e-34,0.013729307,0.007709437,0.047611352,-0.053623024,-0.011740861,-0.005494344,-0.047581002,-0.043498326,-0.050757296,-0.13164665,-0.08761451,-0.055483226,0.0799192,-0.035270385,-0.044639476,-0.000603199,-0.07745666,0.045778807,0.027805708,0.0017464269,0.042073146,0.10748961,-0.0025256055,0.022383636,0.08580719,0.026531821,-0.06727325,-0.035370797,0.029980311,-0.0018503948,-0.014142532,-0.06650872,-0.07556565,0.068977825,-0.0032021042,-0.052946504,-0.023087978,-0.08027679,0.008446788,0.040783465,-0.052696425,0.028592128,0.049721476,0.025517799,0.044985887,-0.049253646,-0.018679507,0.027815545,-0.09726479,0.0009803093,0.05145238,-0.024595639,0.00827978,-0.07726316,0.0012103477,-0.05732092,0.0013544428,0.04161497,0.04303341,0.07785437,0.073300555,0.0789388,-0.008601223,0.0454392,-0.028802538,0.049789626,-0.05257135,-0.103978954,0.05200819,0.1204994,0.04363327,-0.021556083,0.0789757,0.028587969,0.040555745,-0.044440027,-0.006347802,0.018552339,-0.018957043,0.070622705,-0.08441227,-0.052823678,-0.018080626,-0.031907704,-0.037750944,-0.01500389,0.040419333,-0.042731978,0.04156726,0.04085574,0.09639222,-0.00038663324,-0.07364188,-0.010831948,0.04573547,-2.1181953e-33,0.11160849,-0.0845574,0.034559824,-0.016636932,-0.075075604,0.028947974,0.021609033,-0.090952784,0.06082924,-0.031879075,0.096189946,-0.0034247567,0.09237813,-0.052650552,0.03639825,-0.0510523,-0.023369538,0.025494978,-0.030126713,0.023246128,0.038833965,0.05130309,0.008010175,0.043927647,0.019138979,0.0058718068,-0.058580775,0.051287513,0.054271087,-0.038573157,-0.060874958,0.08594808,-0.086132266,-0.025700133,-0.0549011,0.029626893,-0.02299673,0.017804474,-0.0052641076,0.010169033,0.020423437,0.08553367,0.0014565579,0.021250661,-0.054566942,0.054341525,0.06210397,-0.017172059,0.07239432,-0.07931674,0.055241507,0.035819337,-0.0039883126,0.03508614,-0.016002716,0.05641599,-0.02844893,0.047071733,0.007959927,-0.02136051,-0.042887695,-0.07609046,0.048265487,-0.02185404,0.040272858,0.05676676,0.0058251773,0.029279806,-0.0399673,0.0035865447,-0.025164284,-0.023074817,0.04967794,0.036373377,-0.008012755,0.010681172,-0.03311027,0.014763854,0.009572318,-0.12587069,-0.015554918,0.050906617,-0.019572772,-0.022176612,0.013841405,0.024341544,0.03326084,0.019575171,-0.017018847,0.038655475,-0.013620793,-0.007860689,-0.030223317,0.018103406,0.05917193,-3.4322817e-08,0.05357549,0.027378887,0.025369124,-0.029385863,0.06270126,0.014077711,-0.05554368,0.05024405,0.08638868,0.030226298,-0.03709013,0.05977454,0.029877188,-0.02747327,0.031824905,0.06837029,-0.044228617,-0.039733667,0.0006054585,-0.047974218,-0.021909628,-0.008553364,-0.088520184,0.068407156,-0.03064188,0.054760955,-0.0075677456,0.027833315,0.018390734,-0.100372165,0.010966098,-0.018405026,0.010023642,-0.02701414,-0.0030041644,0.033277713,-0.0053861146,-0.026294854,-0.059398375,0.023759622,-0.040682666,-0.085718766,-0.08301881,0.03135785,-0.042820424,0.045171328,0.025694812,-0.025244115,-0.03876266,-0.0132402005,0.058766775,-0.02853838,0.0016014464,-0.1214664,0.013180676,0.008847653,-0.006006626,-0.06695206,0.033239428,-0.006048931,0.05658032,-0.037713435,0.133717,-0.023673078 +2.7.1.162,"This enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway in the probiotic bacterium Bifidobacterium longum. Differs from EC 2.7.1.157, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetylgalactosamine and N-acetylglucosamine at similar rates. Also has some activity with N-acetyl-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.",384,1.0,0.005015411,-0.052043356,-0.030296488,-0.019356811,0.054769676,-0.02152344,-0.022296872,0.054864507,0.010924223,0.01472692,-0.037188686,0.017827883,-0.02585447,0.032828826,-0.048572674,0.032926995,-0.00022818097,0.014922561,0.041167386,0.0120653715,0.13431008,-0.011188338,-0.042830706,0.023120735,0.01730707,-0.025636738,0.10869539,-0.05583913,-0.076563045,-0.06948545,-0.025694557,-0.017653126,0.11769716,-0.027844874,0.026256504,0.13245367,0.0062105465,-0.034421068,0.063989885,-0.05440222,0.05848236,0.014709776,0.014165463,-0.02854218,-0.0077546868,0.0025405977,0.032978754,0.012444041,0.07090057,-0.024654731,-0.036602728,0.00011465817,-0.0023880869,0.047475837,0.08991434,0.038029764,-0.05378262,-0.053951416,0.019620584,0.02732697,0.030248595,-0.013366671,0.047301717,-0.0040977043,0.063318774,-0.07415156,0.05388665,-0.043467693,-0.013358678,0.003027586,-0.102486156,-0.025069159,-0.026341608,-0.019919615,0.041389402,0.042899527,-0.010579453,-0.08185331,0.048487887,-0.06477616,-0.019914849,-0.038786687,-0.0007287431,0.030956792,0.008995629,-0.07531227,0.10780445,0.0038579646,0.04552487,0.042887047,-0.008936015,-0.023843886,0.05192834,-0.046748713,-0.080699004,-0.050881475,-0.015844673,0.014592632,0.007395931,-0.05156466,0.01938599,0.05029338,0.031208925,-0.06628481,-0.07373855,0.044899628,0.015331696,0.09970966,0.110259704,0.062402654,-0.0069116913,0.03900049,0.0011427031,0.024935365,-0.07137503,0.14947881,-0.017211203,-0.10273167,-0.06073261,0.0726511,-0.027618848,-0.033688217,-0.009560525,0.043687902,-0.020996526,0.13983999,0.04483314,2.7459537e-33,-0.017743487,-0.020536207,0.03838522,-0.04790826,0.053042408,-0.0018500884,-0.07055712,-0.0673692,0.029657992,-0.09156399,-0.02697257,-0.040341306,0.030613646,0.025878225,-0.043390583,0.010898831,-0.059290476,0.0011052546,0.06576194,0.03604646,-0.039472926,0.033715565,-0.028489325,0.015516624,0.09211052,0.062043186,0.026741428,0.023246408,0.010877479,0.0010697646,0.01878095,-0.096520774,-0.088772014,0.05541281,0.02623511,-0.035061233,0.013493428,-0.02363211,0.024960754,0.02344879,-0.05644664,0.017005255,0.009280281,0.002118127,0.005876475,-0.08707322,-0.018404666,0.06659861,-0.0059018093,0.115663156,0.06483189,-0.09839617,-0.007165298,-0.0515,-0.03605192,0.029516159,-0.05370779,0.01793002,0.102188334,0.040002614,0.07501981,0.07573034,-0.00019633958,0.053560853,0.071593344,0.05265598,-0.08557443,-0.04086181,0.045113493,0.00738308,-0.09255989,-0.026324121,0.05072895,0.057194352,-0.04493564,-0.05856264,-0.059518114,-0.015249615,0.01526183,0.048252307,-0.0032780936,0.0025190176,0.01258691,-0.03684302,-0.042587195,0.000112896865,-0.033050247,-0.08534982,-0.05612718,0.018029151,0.029458059,-0.0067471066,-0.09046298,0.062316604,0.018790985,-5.0564716e-33,0.12826216,-0.08705347,0.13145755,-0.014074485,-0.05468677,0.034418833,0.02807722,0.021121822,0.02059642,-0.07483401,0.06772274,-0.038283415,0.0077760266,-0.017910514,0.031199163,-0.045169268,-0.020117601,0.06317565,-0.07545319,0.001017527,-0.0036713178,0.10465736,-0.027216982,0.009758118,-0.010131119,0.002282068,-0.05345447,0.052538846,0.020516602,0.038367633,0.01752606,0.06922708,-0.08837069,-0.06768439,-0.014380596,0.01651203,-0.023510404,0.0024568306,-0.020676712,-0.008136823,0.0042642523,0.078607686,-0.007817665,-0.009906491,-0.034795273,0.0268685,-0.04760682,0.0229661,0.01688651,-0.054980427,0.04762468,-0.015557397,-0.041264888,0.008235786,0.010007902,0.03961695,-0.01208613,0.063542895,-0.03713596,-0.04555198,-0.06714066,-0.022671593,0.09907859,-0.040041093,0.056409564,0.033816185,-0.061318398,-0.0022793284,0.02071642,0.011126631,0.05037566,0.077086896,0.0040159714,0.037145644,-0.031528056,0.04555415,-0.11039612,-0.03276702,-0.009966822,-0.05394644,0.010947862,0.020518905,-0.064988494,-0.05985544,-0.03525902,-0.047619447,-0.019168982,0.09428417,-0.00033078933,-0.0073206564,-0.054677125,-0.10845889,-0.089222126,-0.0013504762,-0.012153663,-4.2719325e-08,0.04245523,-0.0013913257,0.040346593,-0.05926933,0.011790759,0.010919183,-0.041092776,0.042160396,0.093096785,-0.05648663,0.021805905,0.114784226,-0.023153743,-0.0038874862,0.007236179,0.01639195,-0.031135764,-0.015863454,-0.003899161,0.029588642,-0.09769543,-0.09287149,-0.15435435,0.05576492,0.043490242,-0.06574341,0.058728274,0.05659171,-0.015649041,-0.084933944,0.02671592,0.021552125,-0.01861014,-0.020984547,-0.027733656,0.0036784916,-0.090286605,-0.0024667084,-0.010170412,0.067968436,0.034353312,0.00077350036,-0.051343877,-0.023580728,-0.059066806,0.031366695,0.010108826,0.031210424,-0.08900848,0.0054899505,-0.0065502967,-0.044529606,-0.07255859,-0.058747984,-0.02586567,0.01688436,0.02672699,-0.077965714,-0.028214676,-0.050934903,0.043680057,-0.04959032,0.119350865,-0.040450774 +3.2.1.165,"Chitosan is a partially or totally N-deacetylated chitin derivative that is found in the cell walls of some phytopathogenic fungi and comprises D-glucosamine residues with a variable content of GlcNAc residues [4]. Acts specifically on chitooligosaccharides and chitosan, having maximal activity on chitotetraose, chitopentaose and their corresponding alcohols [1]. The enzyme can degrade GlcN-GlcNAc but not GlcNAc-GlcNAc [3]. A member of the glycoside hydrolase family 2 (GH-2) [4].",384,0.99999994,-0.026068002,-0.085066326,-0.028590068,-0.056385744,0.062859125,-0.026483936,-0.00038421655,0.020811474,-0.003301963,0.071541786,0.12004321,0.049511373,-0.03425328,0.06999897,-0.17031454,-0.00894872,-0.017675271,-0.055785835,-0.02722091,0.02334253,0.00029998043,0.005158176,0.074132934,0.029218292,0.029016795,0.024520572,-0.009687191,0.022959663,0.012100307,-0.031725906,-0.042700753,0.014041484,-0.028711919,0.015173514,-0.0050901608,0.07270195,0.0030982515,0.026910327,0.078510605,-0.013939498,-0.017367933,-0.025008483,0.001775166,-0.03582249,0.0023006892,-0.0678756,-0.09482458,0.016526373,0.032902278,0.046563797,0.016406883,0.013126333,0.018729595,0.00435114,0.032835342,0.043379307,-0.05290909,-0.048336133,0.019906173,0.11807518,0.009989244,-0.0025089062,-0.045623913,-0.06459526,-0.07708623,-0.03376496,0.012404888,-0.07266199,-0.027351607,0.027163856,-0.008048387,-0.03924678,-0.037698284,-0.0016954708,0.046184525,0.037053067,-0.04661188,-0.04061302,-0.03825936,-0.04683973,-0.006196321,-0.01185863,0.0863918,0.088361,-0.08283135,-0.03360562,-0.01674874,0.040526547,0.08615849,0.0750056,0.017097896,-0.0062375786,0.066985816,-0.001207169,-0.032829948,0.016622752,0.058827467,-0.01872104,0.061471056,-0.021742402,0.017129185,-0.0400649,0.006711652,-0.094617784,-0.015125562,0.053029437,0.050723415,0.029796476,0.088943645,-0.0679071,-0.0024877896,0.09461619,-0.020878918,-0.045331776,-0.11017131,0.067263454,0.033039976,-0.056437995,-0.009589624,-0.045844365,0.032776203,0.015976246,0.0010704042,0.053005166,-0.0451585,-0.021667372,-0.015269877,3.291745e-33,0.035326645,-0.0007283081,0.004554771,-0.036516488,0.009789801,-0.008013876,-0.027916344,-0.06208695,0.020804398,-0.061616194,-0.10691138,-0.012601727,-0.12453237,0.054578688,0.002482161,0.102818176,0.030696392,-0.05246377,0.07124332,0.050548546,0.006787544,0.10517135,-0.076827824,-0.034683466,0.11601734,0.051592696,-0.026665915,0.05634806,0.028670503,-0.0025015466,0.03063436,0.02390003,-0.018111426,0.047716167,0.043442138,0.054185517,-0.039337903,-0.027005361,0.056257855,0.049268004,0.048307993,0.029717147,-0.011487158,-0.031475216,0.028262964,0.025240967,0.050086167,0.040493883,-0.06357221,0.018815136,0.011093733,0.016376149,0.033698894,0.059564535,-0.042267613,0.01666605,0.022682097,-0.03425053,0.10862863,0.069945805,0.0042083412,0.022680257,-0.010042875,-0.0065889694,0.008859497,-0.0018611319,-0.06849185,-0.05404453,-0.054529615,-0.016734613,-0.028837651,-0.024597755,0.039754968,0.0138116935,0.05007664,-0.07533042,-0.030849207,0.03828045,-0.04578225,0.04338894,0.049026392,0.050259296,-0.06756498,-0.03884849,-0.05597832,0.076684274,-0.0066504776,-0.09443571,-0.025051512,0.0031702959,-0.049192026,-0.032778088,-0.009667725,0.022019632,-0.0261011,-4.5666677e-33,0.11801878,-0.10278492,0.09098152,0.02919248,-0.047406957,0.018909222,-0.010830536,0.01550753,-0.012038318,-0.026919246,0.03292402,-0.005586127,-0.0118164355,-0.027118329,-0.025416618,0.05320842,-0.040181674,0.0725784,-0.039376214,0.002376417,-0.095161974,0.095626086,-0.018207638,-0.024203198,0.06271293,-0.01996513,-0.009540065,0.037528522,-0.0075959293,0.01746197,-0.08535532,-0.035656247,-0.018801842,-0.08242346,0.005256102,0.030950952,-0.01879029,-0.052078307,-0.041366756,-0.0020900087,-0.022934377,0.0072143055,0.052014746,0.05355057,0.018500717,0.092515625,-0.066721864,-0.04967618,-0.0920267,-0.01863555,0.026285628,-0.0023746202,0.03363738,0.06121267,0.09814759,0.03997282,0.05730549,0.09248523,0.021101097,-0.027494516,-0.008325626,0.015220056,0.01890103,0.04344777,0.032896455,0.100688115,-0.07885148,0.06956163,0.0286773,-0.016586056,0.013438033,-0.020968748,0.061173316,0.01126253,0.023512427,0.058048826,-0.09926029,-0.050091226,-0.057387188,-0.029127905,0.082214765,-0.025454069,-0.026348004,-0.049755976,-0.036856122,-0.048210923,0.02964986,0.13385573,-0.12235024,0.040400732,0.026666533,-0.045866366,-0.059374306,0.04556085,0.06929059,-4.023252e-08,-0.03509888,-0.039704125,-0.031655896,-0.14149639,0.0010245598,-0.019380046,0.037854042,0.06656431,0.034869898,0.0034936608,-0.0092969965,0.09704918,0.0039060502,-0.015123247,-0.08941885,0.0380107,-0.01777394,0.009603311,-0.0026770956,0.053773474,-0.08297597,0.074216336,-0.1204088,0.006595846,-0.061764378,-0.024623305,-0.008853875,0.061736476,-0.09866953,-0.038402632,0.023880996,0.04325195,-0.006965647,-0.09121775,-0.0018626214,-0.0038231872,-0.068202116,-0.08466443,0.05821565,-0.01272389,-0.020896234,0.02906514,-0.040534187,-0.009514745,-0.04172001,-0.074244425,-0.023899311,0.046929557,0.008338019,0.06026783,0.03163068,0.015864752,-0.06361632,-0.12585035,-0.053442143,-0.034632903,0.042879183,-0.05015091,-0.05335882,-0.06200698,-0.028661491,-0.038500987,0.13329428,-0.00030893978 +4.2.3.28,"This class I diterpene cyclase produces ent-cassa-12,15-diene, a precursor of the rice phytoalexins (-)-phytocassanes A-E. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.",384,1.0,-0.080442764,-0.031166295,-0.038385045,0.042210456,0.058023967,0.03344008,-0.02402957,0.092206374,0.08437635,0.025781848,0.11765006,-0.029766196,0.059930388,0.030756101,-0.11153589,0.010089553,-0.055858333,0.04394958,-0.041735545,-0.023898536,-0.0027035759,0.07374159,-0.027403986,0.032290585,0.00782033,-0.019983208,-0.012959107,0.028716778,-0.030405285,-0.044363562,-0.037126765,-0.02322801,-0.024361355,-0.033294152,-0.012501292,0.073767535,0.007992199,-0.045972478,0.11101493,-0.019375142,0.019560618,-0.007396439,0.04535823,-0.008398497,0.0057285414,-0.036898267,-0.083234616,-0.038824633,0.034508687,-0.091302544,0.014096334,0.019853262,-0.04406877,0.07908499,-0.012137529,-0.03461161,-0.025054706,-0.0076063867,0.011237204,0.101100415,0.022175819,0.012439641,-0.0028170543,0.0058030733,-0.102850355,-0.021619482,-0.06269414,0.0032381532,0.0024848953,-0.063747615,-0.04427223,-0.065725595,-0.115026794,0.05223299,0.0009708845,0.07871323,-0.024959464,0.064010814,-0.07427345,-0.011266703,0.06728108,0.0537711,0.090966836,0.083893664,0.087246805,0.042951968,-0.023401435,0.033267345,0.08179929,0.07430305,0.05143124,0.02971215,-0.032582104,0.056619138,-0.046058204,0.030720582,0.033261932,0.007818492,-0.051761262,0.015678165,0.021075657,-0.08674668,-0.15505832,-0.014179284,-0.014673978,-0.010760821,0.048451457,-0.07845316,-0.049781274,-0.032694604,0.008476256,-0.02990983,-0.0589045,-0.08023882,-0.020511685,0.07141996,0.0019289507,-0.036538426,0.050033942,-0.057786714,0.04649069,-0.04695589,0.010456757,0.024180507,-0.046924528,-0.03500215,-0.05560603,3.709095e-33,0.014217977,0.052123733,0.03312692,0.018774545,0.031112835,-0.078061625,-0.007370295,0.025489276,0.0070403926,-0.10403948,-0.10169639,-0.020496933,-0.047770206,0.0042428323,0.0065755444,0.06293667,-0.027796732,-0.023384882,0.010701621,-0.06879218,-0.042390045,-0.0033079372,-0.023385724,-0.021701768,0.049742367,0.02522758,-0.013544786,-0.029733716,0.061212577,-0.016962687,0.026608972,-0.092665784,0.0011517066,-0.0059640226,-0.009770197,-0.009604568,-0.017825563,-0.00935889,-0.034571327,0.019247986,-0.027338622,0.07472865,-0.035109796,0.009848526,0.094338164,0.057969708,-0.0400039,0.043243777,-0.02599812,-0.041429453,0.03404803,0.02847299,0.022587346,0.020951286,-0.03180845,0.033468716,0.059504423,-0.024710646,-0.0135038,0.09850149,-0.049133077,0.021304509,-0.041056827,0.022297235,-0.04304556,0.03570796,-0.12893277,-0.08083258,-0.025818309,0.05023626,-0.048711535,-0.054429077,0.012065753,-0.07213623,0.07842288,-0.0006558338,-0.070855595,0.00059019454,-0.055725113,0.028467337,0.05256063,-0.054571103,-0.026909111,-0.00074548647,-0.07914631,0.0078002233,-0.050011124,-0.0519184,0.08297386,0.02960661,0.075488746,-0.0027324408,-0.011682311,0.03857972,-0.05325486,-3.9665576e-33,0.038596753,0.015534077,0.06364045,-0.037414823,-0.01651228,0.02662643,-0.100287974,0.016124424,0.079059035,0.026521122,0.0070073204,-0.0015069178,0.016793348,0.04534988,-0.04950918,-0.009929098,0.04172527,0.11025209,-0.015022232,0.011925045,-0.05344583,0.085433535,0.010543543,-0.023326324,0.022872886,0.029013153,0.019835701,0.08492434,0.015995512,0.027856668,0.0063736904,-0.06569633,0.024675032,0.021276783,-0.056564514,0.07671597,0.013544709,-0.084083304,-0.028248765,0.075605094,-0.014655599,-0.03857585,0.018756766,0.060637817,0.011354957,0.023519607,-0.06277644,0.09236974,0.027959123,-0.01872508,0.052789133,0.014291461,-0.03883328,0.06014369,-0.009807078,-0.011392877,0.08407845,0.06930368,0.013481183,0.012091401,0.049056433,-0.031503752,-0.046765946,-0.04518778,0.009636358,0.021271784,-0.026594002,0.09629933,0.037853524,0.02257128,0.020905647,0.047136787,-0.017485434,-0.01653137,-0.05276109,0.017566517,-0.05481428,-0.07296485,-0.012108487,0.07560405,-0.05200795,-0.03037728,0.01727256,-0.09000238,-0.020017855,-0.03566928,0.04573929,0.07799708,-0.004378199,0.05380056,-0.00096640625,-0.004348791,-0.018121555,0.15560362,0.049324885,-4.0214655e-08,0.05879691,-0.11667014,-0.04942236,-0.030123904,-0.10506206,-0.060213543,0.028190637,0.0015904948,0.04496053,-0.018282467,-0.02672563,0.07716744,0.03020238,0.02289089,0.03984965,0.06246606,0.044971094,-0.003191405,0.012164324,-0.00897918,0.03344247,-0.013462186,-0.02042476,-0.0404012,-0.049300674,-0.119922936,0.0065992177,0.076109424,-0.007470727,0.0019769322,0.03511882,0.01540747,0.0076626465,-0.055467337,-0.068119094,0.06273391,-0.11105704,-0.07102062,0.044462845,0.023893131,-0.05346938,-0.05590426,-0.10909594,0.02812155,-0.014256191,-0.0036964812,0.015108136,-0.027751155,0.02733002,-0.008468502,0.0032680337,-0.023239909,0.08111549,-0.05395442,-0.044868838,0.022147896,0.04512778,0.01763787,-0.044173576,-0.115912415,-0.049510393,0.004884726,0.20870623,0.062374014 +4.2.3.29,"ent-Sandaracopimaradiene is a precursor of the rice oryzalexins A-F. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. As a minor product, this enzyme also forms ent-pimara-8(14),15-diene, which is the sole product of EC 4.2.3.30, ent-pimara-8(14),15-diene synthase. ent-Pimara-8(14),15-diene is not a precursor in the biosynthesis of either gibberellins or phytoalexins [2].",384,1.0,-0.105086945,-0.008149471,-0.050542228,4.4164146e-05,0.08359911,0.0773579,-0.070625745,0.05395544,0.06646657,0.006363656,0.119402386,-0.032143354,-0.010590265,0.010886298,-0.06978944,0.052201144,-0.042661313,0.060697403,-0.037270084,-0.044034142,0.018207837,0.00096916757,0.007988436,0.025810773,0.023670705,-0.0353134,0.033192553,-0.031738624,-0.07411908,-0.05099036,0.008641587,-0.05349665,-0.03289915,-0.034881115,-0.022674171,0.03429821,-0.012468402,-0.08747587,0.14963657,-0.0017968046,0.008563579,-0.031358827,-0.04820492,-0.02489118,0.0068857917,-0.08358835,-0.039614785,-0.027790729,0.021344876,-0.022324963,-0.019909775,-0.008639546,-0.020487588,-0.0029143966,0.034262095,-0.07016604,-0.016912127,0.011428562,-0.04080668,0.082674295,0.052248184,-0.005750096,-0.01894538,-0.052440524,-0.13377866,-0.02593408,-0.0040682107,-0.0073965443,0.00844754,-0.01587201,0.0051938584,-0.049337424,-0.084144786,0.075880125,-0.005557898,0.08703697,0.004410006,0.029359164,-0.047888417,-0.0058959085,0.06381458,0.050702646,0.06910406,0.040722642,0.07082286,-0.031126585,-0.017203132,0.14402433,0.059952553,0.064466216,0.040396724,0.014914298,-0.032412432,0.06250442,0.04058417,0.031479117,-0.04458076,0.009121472,-0.06852547,-0.005888805,0.004241538,-0.018745586,-0.11802929,-0.053447273,0.036997974,-0.00036069925,0.07425061,-0.010688718,-0.036490012,-0.02845046,0.0030566417,-0.106155336,0.015036331,-0.02808274,-0.053549055,0.103508085,-0.048412584,-0.029274717,0.008573589,0.0029921134,0.0485248,0.0012420501,0.016977008,0.072799325,-0.057721056,0.015143088,-0.09249104,1.7206558e-33,0.07486648,0.041634485,0.005907341,0.059033714,-0.00013890331,-0.022125462,-0.036173683,-0.009096516,-0.00683721,-0.12322689,-0.14990148,-0.05368805,-0.038701143,0.03288954,0.011137424,0.025749931,-0.03481388,-0.0577094,0.049677923,-0.042239927,-0.092164464,-0.0027796165,-0.09298593,-0.045697153,0.017403949,0.018537778,-0.031521067,-0.04732151,0.030267205,-0.024106706,0.030527288,-0.06468962,-0.040820472,0.006932327,-0.012678656,-0.026946438,0.0071244743,-0.03397973,-0.047659587,0.029445807,0.044433117,0.08448205,-0.022988439,0.017022876,0.077494666,0.035513375,-0.06896667,0.08720355,0.05217516,-0.008748223,0.043475185,0.064610906,0.050742332,0.0413961,-0.007336082,-0.00788301,0.027980126,0.0043796175,0.015263422,0.06791855,-0.0016857623,-0.0095867375,0.073343396,0.0027619523,0.012116313,0.052961208,-0.09905998,-0.039952744,-0.046279423,0.024699364,-0.019852368,-0.05094899,0.049614213,-0.029785072,0.026884533,-0.042535286,-0.024623778,0.01278469,-0.07406324,0.02579926,0.035683148,0.008100753,0.01765824,-0.031230284,-0.10516563,0.020504823,-0.025989816,-0.0009447396,0.06354308,0.013045583,0.039597433,0.012634178,-0.05757731,0.071719825,-0.048183877,-1.9311097e-33,0.0352901,-0.01679752,0.042550612,-0.07030038,-0.07388973,0.055726197,-0.040149353,-0.0042329687,0.08692025,0.06483868,0.052668404,-0.062089156,0.09297603,-0.038994372,0.012934517,0.022746718,-0.025971305,0.07846865,0.0132527305,-0.041571602,-0.1171191,0.09279085,-0.019724866,0.024989873,0.045167856,0.0522165,0.0047530257,0.027099095,-0.04265151,0.019633291,0.03833933,-0.052508738,-0.016370578,0.077870846,-0.01878353,0.082774885,0.07224669,-0.071942024,-0.02962075,0.078744255,-0.02191766,-0.00039555534,0.054740034,0.03297257,-0.0048479075,0.033979286,0.02146894,0.01747556,-0.02442723,-0.037115354,0.049617898,0.026958799,-0.049103685,0.024905981,0.0038033612,0.0036217407,0.026144935,0.050399225,0.010286224,-0.04603075,0.032436635,-0.046813436,0.017436136,-0.038639218,-0.0011346817,0.059218653,-0.060893305,0.09432017,0.06809699,-0.01576774,0.006205964,-0.012259386,-0.040341817,0.043325268,-0.020683907,0.023928603,-0.04535111,-0.07808182,-0.026075603,0.010395874,-0.06077983,-0.079714015,-0.026938826,-0.06390105,-0.030979438,-0.05699241,0.051291697,0.05453005,0.016905688,0.044298586,0.011603072,-0.027375337,-0.05997325,0.16354789,0.020285388,-4.23203e-08,0.09428913,-0.10257258,-0.02494417,0.01771437,-0.097085446,-0.054308668,0.053761557,0.058849983,0.030315917,-0.038454425,-0.040750775,0.027179228,0.006593333,0.045650937,0.047328707,0.010922309,0.016132519,0.08248539,0.021355875,-0.0042177816,-0.037913986,0.019310657,-0.044674486,-0.05283398,-0.06484281,-0.05059836,-0.015650423,0.07502221,0.03506759,-0.035967458,0.025993034,0.002126584,0.01628428,-0.065362684,-0.078692295,0.07464954,-0.032937635,-0.038676318,0.040580727,0.065827236,-0.05186866,-0.0677854,-0.08094175,0.007696209,0.021138724,-0.028372882,0.05009077,-0.005869919,0.0093146125,-0.0061979163,0.0101509765,0.018461844,0.10784306,-0.07085726,-0.058881093,0.026891926,-0.024560625,0.0061876043,0.031294905,-0.0712331,-0.060842372,0.022874001,0.19962357,0.05739529 +4.2.3.30,"Unlike EC 4.2.3.29, ent-sandaracopimaradiene synthase, which can produce both ent-sandaracopimaradiene and ent-pimara-8(14),15-diene, this diterpene cyclase produces only ent-pimara-8(14),15-diene. ent-Pimara-8(14),15-diene is not a precursor in the biosynthesis of either gibberellins or phytoalexins.",384,1.0,-0.11154261,0.0048714955,-0.035443254,-0.04172417,0.026519403,0.031638272,-0.088000305,0.037381493,0.07751581,-0.027239725,0.05486489,-0.04547737,-0.017637126,-0.0074776104,-0.046987217,0.035860647,-0.03716506,0.063461944,0.0060007353,-0.033520464,0.040498536,-0.027183851,0.020128552,0.030058356,0.028935842,-0.029532028,0.03402736,-0.039737735,-0.07416858,-0.06263169,0.011188979,-0.050103735,-0.034659952,-0.074945845,0.047153044,0.006678925,-0.03364468,-0.037855927,0.14066143,0.024395902,0.024074133,0.031605784,-0.05188238,-0.017870981,0.0356744,-0.060876742,-0.046916146,-0.013370374,0.0011810579,-0.013331213,-0.03629346,-0.06387018,-0.041846856,-0.03070661,0.048939917,-0.07070185,-0.060170624,0.011734351,-0.016599875,0.038205054,0.055794917,0.039060388,-0.034757644,-0.070455484,-0.107774384,-0.053465903,0.030390702,0.0076589296,-0.011163051,-0.036772106,-0.03667457,-0.06868068,-0.11453098,0.05749012,-0.030480156,0.07716414,-0.015836528,0.025371155,-0.07524982,-0.0032588951,0.060847804,-0.006243743,0.027163327,0.010570423,0.08362569,0.0019690609,0.014111544,0.12050852,0.04839517,0.089266464,0.033479765,0.015007797,-0.03258904,0.040210284,0.030506104,0.002125498,-0.019934317,0.09263039,-0.059448283,-0.020004528,0.031647865,-0.0047892933,-0.06674829,-0.08359302,0.011906329,-0.0060944697,0.0731776,-0.017090302,-0.029434029,-0.027802564,-0.014096283,-0.113021135,0.019520387,-0.029520025,-0.035401527,0.13547403,-0.054028865,-0.033312175,0.012415011,0.037995867,0.054288395,-0.022754408,0.057311676,0.07747697,-0.03045568,0.037897237,-0.08429101,1.6571851e-33,0.0797338,0.026724275,0.030000405,0.06539801,-0.021972997,0.026149614,-0.049873084,0.010192561,-0.034613993,-0.13409802,-0.12887245,-0.06690513,-0.027872816,0.0007854907,0.007098787,0.012006673,0.018932508,-0.042970166,0.029263664,-0.031624027,-0.06768167,-0.009486464,-0.09253874,-0.021906076,0.029483695,0.0459554,-0.029379917,-0.014826026,0.0590432,-0.020731816,-0.0032679592,-0.07348555,-0.014952571,0.0081613995,0.014499124,-0.03254238,0.015488689,-0.040832087,-0.02737183,0.011580209,0.025297167,0.019254947,0.0042048045,-0.014400972,0.0687163,0.036308687,-0.07402457,0.06439603,0.04207105,-0.01854036,0.02725447,0.08738793,0.020881351,0.028397333,-0.021905672,0.015369739,0.0070781205,-0.004629076,0.03539213,0.053661514,0.0104223145,0.044995263,0.0154602425,-0.051541984,0.02818542,0.082831115,-0.091624424,-0.021202238,-0.053112686,0.06078499,-0.023778327,-0.06458999,0.04778497,-0.0066074063,0.062726006,-0.023963433,-0.052444004,0.036649965,-0.032788496,-0.004752332,0.0055000493,0.028135912,-0.006929794,-0.031586453,-0.050575063,-0.02304184,0.012074658,0.033639535,0.055718057,0.05228293,0.01987148,-0.026102675,-0.0653816,0.07313098,-0.030107252,-2.3933408e-33,0.008925596,-0.008762222,0.016492015,-0.05757319,-0.074608125,0.061989672,-0.037231375,-0.06223014,0.10094541,0.07935718,0.03932843,-0.07994579,0.1055756,-0.039663445,0.0126734115,-0.0016076239,-0.04109935,0.035819765,0.01096899,-0.03869857,-0.05588215,0.04471937,-0.033886712,0.061691996,0.021311078,0.026021749,-0.024437103,0.061797988,0.0031038767,0.016376993,0.027867716,-0.041573822,0.0054083937,0.04751907,-0.06803212,0.08354062,0.06278429,-0.015951853,-0.019091634,0.088237636,-0.030760793,-0.03638846,0.03510181,0.046230618,0.052417967,0.038074076,0.046286322,0.012125773,0.0009334618,-0.021386836,0.10833103,0.057354696,-0.02455172,-0.0010513435,0.042830892,0.0014529423,0.026972305,0.0778062,0.01718759,-0.058957074,0.0045990376,-0.09896256,0.013136185,-0.038988326,0.035686545,0.051532097,-0.08417068,0.09461468,0.039446075,0.0045059235,0.0015956018,-0.020609913,-0.058856625,-0.00013570927,-0.011074707,0.018654477,-0.03760323,-0.09146417,0.020604558,-0.034193825,-0.07689288,-0.051090047,0.038449295,-0.06826165,-0.056004148,-0.042289738,0.07389175,-0.0015863543,0.014627212,0.051717147,0.011831,-0.0021006167,-0.019441413,0.13718358,-0.023751622,-3.6514315e-08,0.10991098,-0.07612206,-0.003922234,0.02575666,-0.056949157,-0.08326565,0.027882714,0.05655688,0.03260675,-0.002612985,-0.04277387,-0.013104187,0.02415308,0.00444843,0.11150724,0.033120833,-0.0025488795,0.0787388,0.025794398,-0.00779391,0.013961561,0.04500373,-0.048419837,-0.05176758,-0.039814647,-0.106710725,0.019219914,0.044067822,0.00508806,-0.0042530014,0.031544756,-0.01889252,0.020268748,-0.06661319,-0.09087475,-0.011082979,-0.062097058,-0.015079326,0.048972946,0.06304477,-0.050308134,-0.08525806,-0.10877479,0.02915451,0.01230825,-0.023564026,0.07356635,-0.08080018,0.005386835,0.008445148,-0.0076806494,0.040302955,0.13283291,-0.074028656,0.0032632945,0.037781484,-0.034851916,0.012232165,0.00846483,-0.065948136,-0.056732718,0.011398086,0.2223999,0.069295816 +4.2.3.31,"This enzyme is involved in the biosynthesis of the diterpenoid viguiepinol and requires Mg2+, Co2+, Zn2+ or Ni2+ for activity.",384,1.0,-0.06647614,0.011330392,-0.08807506,0.021377524,6.531412e-05,-0.029209694,-0.040929977,0.06753379,0.028279658,-0.012487646,0.011698656,-0.04437403,-0.03851969,-0.02452057,-0.05568254,-0.004054964,0.057460874,0.067137696,-0.021426847,-0.011208356,0.11071825,0.044673603,0.014294255,-0.051221874,-0.005070287,0.04305523,0.022540884,0.06595603,0.07464661,-0.022739323,-0.018674705,0.008125052,0.025805779,-0.05041857,0.007890762,0.01494287,-0.03464352,-0.04706628,0.030158702,0.018747233,0.062113963,0.040853366,0.06233592,0.006934939,-0.012092657,-0.052760363,-0.022130305,0.00036527464,0.035213906,-0.0040529077,-0.061899606,-0.046515554,-0.021486007,0.00022344415,0.012448395,0.06465965,-0.10736208,-0.07791748,-0.015519668,0.026578268,0.033816297,0.03183661,-0.0075320518,-0.02478455,-0.015100011,-0.018822819,-0.012232137,-0.016497888,0.020913225,-0.044735216,-0.09709055,-0.06748269,-0.064607464,-0.034272864,-0.09670393,0.047959983,0.02825685,-0.0345206,0.050921336,-0.037365388,0.061421428,0.039495207,0.07959937,0.12572482,0.07928059,0.07491509,0.05174525,0.0025058468,0.052915253,0.10472557,0.04922385,0.038661096,0.0052930634,0.009189777,-0.06346435,0.045283783,0.0044274554,0.008865536,-0.07449947,0.0262444,0.025291871,-0.012745378,0.0026339157,-0.0645991,-0.09515975,0.050623428,0.020451553,-0.009391691,0.027564082,-0.0040427744,-0.007868087,-0.012643954,0.0037994015,-0.0043045883,-0.013378493,0.117289186,-0.025007585,-0.053588342,0.017035484,0.022628235,0.061293975,-0.024317525,-0.003183553,0.0033691607,-0.078964025,0.005942634,0.030492892,2.1246693e-33,-0.019509269,0.042772796,0.024764363,0.058625896,-0.03507423,0.050627172,-0.060282506,0.019462094,-0.06508585,-0.09587559,-0.11063921,-0.09598927,0.014168225,0.0438097,-0.013677271,-0.04188467,0.057542566,0.00041241013,0.111335725,0.011818722,0.082693554,-0.011991032,-0.054738883,-0.019760719,-0.009106902,0.09506756,-0.033816148,-0.07962346,0.06763484,-0.0101255635,0.035115812,-0.046847116,-0.018383183,-0.004348459,0.059329785,0.00078125903,0.004755455,-0.04787631,-0.05736336,0.052870277,-0.025396286,0.031935353,-0.097601466,0.019285457,0.05937494,-0.062517956,-0.025871947,0.064221986,0.05746483,0.05373155,0.021378169,0.034356393,0.023634048,0.026179755,-0.11168912,0.076552704,0.01188395,0.05823765,0.016409723,-0.015190775,-0.042210016,0.03603115,0.016569002,0.03934032,0.049843825,0.07545114,-0.096653625,-0.10866145,-0.010651556,0.13112792,-0.07551279,-0.038101275,0.036597177,-0.011376072,0.08059538,-0.021946076,-0.06338698,-0.016756622,0.040444136,-0.017165413,-0.04656253,-0.021846067,0.02408293,-0.068649225,-0.011980683,-0.06288387,-0.038199488,-0.016979178,-0.0059216865,0.0072409897,0.06835701,-0.050441522,-0.036567707,-0.0099263685,0.023131384,-3.607383e-33,0.011785386,-0.02813422,0.029359728,-0.05988466,-0.05215433,0.08228309,-0.081976555,-0.17375569,0.028187957,-0.0012973137,0.03331476,-0.05775279,0.045914497,-0.022173133,-0.021928407,0.018045098,-0.06774851,0.07076659,0.0020509558,-0.05065571,0.0009350889,0.049383916,0.066767074,0.009071265,0.0015617458,-0.024654558,0.054562464,0.010939371,0.025730351,0.11190221,0.02088175,0.009773104,-0.060817514,-0.044178523,-0.03702761,0.1071047,-0.03316596,0.009309397,-0.000840609,0.041578047,-0.056400828,0.02516378,0.023855492,0.036637243,0.003328832,0.022822948,-0.11117024,0.022011692,0.007761099,-0.074156135,0.08937577,0.055958267,-0.058626384,0.030818544,0.011392246,0.049236316,-0.0003767366,-0.001798648,0.037500076,-0.036620036,-0.042955436,-0.020674352,-0.027174724,-0.06410777,0.048569757,0.017627036,0.01276383,0.08897771,0.06666376,0.005528384,0.08775796,0.09531898,0.07433974,0.03439028,-0.0070932955,0.04539241,-0.0044240346,-0.13015269,-0.02047585,-0.035457406,-0.034949277,-0.014117663,0.01850722,-0.059574146,-0.12434727,-0.0979704,0.04040347,0.08357795,-0.0020656004,0.038808428,-0.03101756,-0.04089289,-0.065948404,0.03232157,-0.01723729,-3.0073227e-08,0.009993973,-0.06280217,0.004365029,-0.013700548,0.021507,0.0318567,-0.0154602155,-0.028331613,0.104618914,0.03313238,-0.017435092,0.01992886,-0.000106597334,0.03546208,0.06879513,0.0683358,0.039859943,0.02648947,-0.015735159,0.00604292,-0.009158047,-0.03488,-0.08893112,0.005025141,0.042674214,-0.14994052,-0.005775197,0.03720137,-0.018517012,0.009106435,0.025551857,0.028543724,0.001808348,-0.04579859,-0.12291767,0.059554666,-0.04834102,-0.04348773,-0.047818404,-0.03047563,0.01473518,-0.082894824,0.025704866,-0.0060448367,-0.067815624,0.0038406109,0.0522057,-0.054566145,0.0024794585,-0.0009415956,-0.03133143,-0.03219944,-0.022915024,0.0025052228,-0.07287016,0.01954425,0.064088896,0.008393481,-0.051057655,-0.109183684,-0.08431097,0.053068005,0.13438362,-0.009014603 +4.2.3.32,"In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides, a structurally unique family of diterpenoids that are highly specific platelet-activating-factor receptor antagonists [1]. Levopimaradiene is widely distributed in higher plants. In some species the enzyme also forms abietadiene, palustradiene, and neoabietadiene [2].",384,1.0,-0.042671565,0.007793226,-0.08875822,0.0013424829,-0.06498553,0.0341467,-0.07136041,0.08985271,0.066263005,0.07506276,-0.012854667,0.015790153,-0.030182268,0.008066582,-0.05729911,0.09251349,-0.08907877,0.026039287,-0.00042161546,-0.004980173,0.00457727,-0.008213819,0.038700137,0.007249574,0.062251393,0.027778095,-0.014859135,-0.0697638,-0.011374596,0.009693602,0.0074941544,0.0593346,0.02238495,-0.07179342,0.0071205636,0.09484864,-0.04513282,-0.08523646,0.007255713,-0.0010479853,0.05706699,-0.009888015,-0.003059424,-0.07392634,-0.02740338,0.0041580815,-0.066755325,0.10096636,0.06352348,-0.022933282,0.015149708,-0.11208365,-0.005957758,-0.0001588082,0.030682217,-0.012012024,-0.009384556,0.0021650004,0.031393334,0.1336495,-0.006762778,0.026372159,-0.07602308,0.05034392,-0.053764533,0.016246475,-0.029299747,0.0214078,-0.029470619,-0.028996527,-0.024941292,-0.06951591,-0.032076567,-0.049453605,-0.021451728,-0.0072718384,-0.023270445,0.06663661,-0.04159317,-0.075807095,0.028760295,0.02471157,0.092544034,0.11143282,0.00094993727,0.040535662,0.0032986375,0.03184399,0.038182084,0.030118259,0.039344143,-0.0036364638,0.0024038171,0.005017094,-0.026007662,0.06372218,0.079908766,-0.019807218,-0.045043044,0.009244195,-0.008811727,-0.01987341,-0.07077962,-0.08672067,-0.06475853,0.06458765,-0.06420232,-0.032656282,0.01414259,-0.051627763,0.005868254,-0.038896736,0.016177917,0.004091785,-0.095892765,-0.00865741,0.047088567,-0.048830386,0.014910934,0.019948479,-0.004239993,-0.016726533,0.008368244,0.0076055424,-0.04352736,0.04620854,-0.013021513,3.117526e-33,0.046115845,0.017955823,0.03770304,-0.024886968,-0.05557897,0.03409755,-0.014477786,-0.02507678,-0.06327182,-0.10085028,-0.059803046,-0.06083705,-0.01277432,0.010335792,0.017300045,0.039797537,-0.020286819,0.013853143,-0.00798483,0.014753544,0.0082747415,0.05792329,-0.08146765,0.06520708,-0.06923511,0.07299804,-0.011748361,-0.05943279,-0.007884007,-0.0026541287,-0.023250207,-0.037976112,-0.026104841,0.03358814,0.009723382,0.01769801,-0.058569208,-0.09506264,-0.06126875,0.017427783,-0.01915782,-0.016563056,-0.05100443,-0.048136026,0.01615,-0.04448489,-0.03359332,0.022816591,0.015894838,0.07270839,-0.007040671,0.073813096,0.060888216,0.078006044,-0.108709596,0.07545032,-0.00090088515,0.0105999885,0.01980991,-0.01083446,-0.051374596,-0.00116029,0.02746857,-0.060092296,-0.0137678515,0.07077916,-0.09426568,-0.04824986,-0.10301834,0.07008761,-0.024329692,-0.042307626,-0.020497099,0.061652593,0.06180476,-0.0034544193,0.034026567,0.08914686,-0.081550114,0.05095956,-0.040466186,-0.036884647,-0.018853981,-0.038027015,-0.052197512,0.0024002371,0.029869104,-0.077392235,-0.017358119,0.020606881,0.0092670405,-0.01296842,-0.054995246,0.057675183,0.011237693,-4.777717e-33,0.023403814,-0.067712374,0.0665972,-0.06958523,-0.032563314,0.1044222,-0.074413516,-0.07934875,-0.019610152,0.022618277,3.9047292e-05,0.09106081,0.03980222,-0.026974618,-0.058050398,0.0014398611,0.071924,0.1100265,-0.06320754,-0.024119513,0.0067121666,0.06791809,0.026732866,0.021566851,0.042684063,-0.04678918,-0.0015006077,-0.013809943,0.023860017,0.056449667,0.019147925,0.050433453,-0.05907173,-0.0053608697,0.029675996,0.11026007,-0.030602088,-0.024097446,-0.0029126753,0.060444452,-0.091143146,0.015598972,0.040835552,0.01765543,0.12297814,0.048413914,-0.08106785,0.024458615,-0.033617083,0.041357413,0.01252152,0.07907407,0.039052807,0.079489574,0.027951047,-0.045603063,0.033363212,0.020621987,0.0560233,-0.047914457,0.00084684097,-0.03728307,0.06936849,0.04627535,0.021022025,-0.011849757,-0.004899856,0.05762619,0.018030666,0.01558776,0.023749499,0.041702796,0.05659369,0.07822597,-0.022696653,0.03161949,0.0105663715,-0.14716545,-0.094335414,-0.08219923,-0.009552194,0.081204996,0.04103752,-0.015202327,-0.0626131,-0.06851604,0.049317993,0.021274166,0.0065270355,0.018895397,-0.039491918,0.0647021,-0.06069358,0.074774384,0.12560906,-4.034164e-08,0.027326653,-0.03750301,-0.044710655,-0.042075194,-0.02282175,-0.059250318,-0.08627067,0.02309224,-0.0259584,-0.04518365,0.0449601,0.048866708,0.034074195,0.0008857545,0.024300285,0.038073014,0.11609429,-0.041162826,-0.033461798,0.09071226,0.0063734036,-0.046707842,-0.0011734735,0.004531302,-0.023185693,-0.14665616,0.012900885,0.03163586,0.043242816,-0.0020755443,0.060796794,0.0737663,-0.004117643,-0.010448654,-0.0335693,0.08290837,-0.059303347,-0.008385956,-0.034107927,0.00037141837,-0.025979875,-0.07409628,-0.022277722,0.007412592,-0.0851551,-0.014039519,0.07595974,-0.006772487,0.004427445,0.043040197,0.0024204664,0.03798936,0.008131273,-0.07118954,-0.04691659,-0.032850448,0.0260805,-0.01134419,0.11064236,-0.13059853,-0.08917972,-0.0295815,0.155981,0.021306872 +4.2.3.33,"This diterpene cyclase produces stemar-13-ene, a putative precursor of the rice phytoalexin oryzalexin S. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation.",384,1.0,-0.095891215,-0.025543137,-0.053555917,0.034716,0.08706427,0.06734236,-0.08599631,0.08120398,0.061603323,0.043806717,0.15614794,-0.050985277,0.0451634,0.038353097,-0.06272882,0.04524615,-0.10278675,0.03915698,-0.0609451,-0.015141493,0.014036821,0.108568154,-0.017769262,0.05787833,-0.00026202467,-0.022481035,0.008017092,0.023683067,0.0053718146,-0.025330251,-0.001136214,0.0060538277,-0.0030385,-0.006627851,-0.024006795,0.055639464,0.0018315312,-0.042071193,0.08532516,-0.039524455,0.016973294,-0.024607072,0.023839178,-0.01444605,-0.005831097,-0.06251264,-0.012869423,-0.058216956,0.063834354,-0.1020194,0.028994052,-0.023372622,-0.016702466,0.0596833,-0.006028244,-0.023966204,-0.028421627,-0.008928775,0.004901885,0.12738764,0.011738674,0.0060362043,-0.019554637,0.0062692757,-0.08134828,-0.025347358,-0.057466324,-0.0067831273,-0.015688835,-0.087331064,0.008863715,-0.08380601,-0.10004488,0.019124309,-0.031009324,0.061924856,-0.002546003,0.069565825,-0.065204985,-0.017647482,0.0791807,0.026611311,0.05556607,0.12798779,0.049109325,-0.0022610005,-0.03507831,0.054489277,0.04572837,0.038737003,0.064897195,0.018019449,0.015058665,0.034358244,-0.02433647,0.070093215,0.034786932,-0.042812843,-0.0011061229,0.023406,0.018773338,-0.030009346,-0.14999582,-0.023482969,0.022920806,-0.015402419,0.03311941,-0.034317765,-0.035581566,-0.0037677116,0.035448585,-0.039583374,-0.0121450825,-0.024069406,-0.027958997,0.04827916,-0.0013627772,-0.023356443,0.05495092,-0.049758703,0.034125537,-0.03965501,0.0037801652,0.06377933,-0.0543154,-0.049341008,-0.054629166,5.1373045e-33,0.061212186,0.041700553,0.018141998,-0.01584476,0.032470647,-0.044625863,-0.015568307,0.00754217,0.00137015,-0.12716533,-0.111503325,-0.022449631,-0.03949396,0.029326906,0.005329544,-0.022103589,-0.05568566,-0.022386383,0.0029654393,-0.01968653,-0.053877108,-0.032366667,-0.064292334,-0.02179043,0.021446574,0.026236964,-0.018052803,-0.054888003,0.027966702,-0.04706512,0.024101479,-0.072440214,-0.03299279,-0.0014248857,-0.01333498,-0.041339815,0.0044377646,-0.040141277,-0.07260404,0.016060026,-0.017713012,0.054110996,-0.05404484,-0.0016254728,0.10053585,0.05799333,-0.10465712,0.07321593,-0.03332866,-0.004066509,0.051797066,0.0372868,0.055187583,0.030711645,-0.013934333,0.022131827,0.048943575,-0.04434393,0.0061181206,0.031335518,-0.045818985,0.015080069,-0.014188547,0.05740929,-0.026446342,0.004938443,-0.08062946,-0.08444629,-0.032934554,0.05845663,-0.0568183,-0.016568312,-0.013829752,-0.05787396,0.010039565,0.006482771,-0.06853752,0.06411398,-0.0032314223,0.026189933,0.035943143,-0.046177834,-0.0067420295,0.002906364,-0.049100716,0.04092224,-0.08239747,-0.06615628,0.03907287,0.014125626,0.056799404,-0.0072818613,-0.03835745,0.05174934,-0.049494535,-4.6203184e-33,0.052589074,-0.021492507,0.06590279,-0.05692732,-0.023545515,0.035184357,-0.08759894,0.05517818,0.065398075,-0.009347967,0.003861811,0.019409722,0.038722143,0.012641197,-0.04157465,0.005938445,0.0514464,0.13818163,-0.0169648,0.003941214,-0.058889568,0.07193375,0.009056025,-0.020243438,0.059937213,0.017807875,0.012230919,0.08387275,-0.03635569,0.049058557,0.031605113,-0.064884946,-0.0063853855,0.01141979,-0.032420248,0.08256291,-0.002455522,-0.09689976,-0.0045447364,0.06686038,-0.02559393,0.003672581,0.030457975,0.040482618,-0.014271531,0.026513398,-0.05419892,0.054721244,0.031210233,-0.03389525,0.02465523,0.033958275,-0.015108871,0.05683753,-0.007800362,-0.025692202,0.07285816,0.015480879,-0.014901937,-0.025108464,0.049254328,-0.027715707,-0.03225091,-0.026816737,-0.026277369,0.045162495,-0.050540086,0.07790574,0.04646086,0.013083894,0.03344758,0.013030737,0.0017105103,0.00017386567,-0.06177127,0.047177255,-0.043338176,-0.10133526,-0.012603026,0.074344486,-0.03915643,-0.014229535,0.0047204928,-0.08232148,-0.037545964,-0.053803567,0.045406155,0.116705306,0.023306152,0.02159246,0.020442521,-0.023232419,-0.032554515,0.17441227,0.08697509,-3.840975e-08,0.043575674,-0.09781816,-0.040817317,-0.047179416,-0.06362464,-0.046525627,0.05790102,-0.004259683,0.027517086,-0.061624967,-0.019064235,0.04970225,-0.045313526,0.038388234,0.049862616,0.05933801,0.08586969,0.037927363,0.011748481,-0.03541491,0.02549613,-0.017118957,-0.007426594,-0.021209989,-0.08236205,-0.081022784,-0.008520925,0.087182276,0.039480537,-0.024291994,0.034264233,0.025827777,0.023562964,-0.044598464,-0.07129917,0.08546428,-0.05356572,-0.09252831,0.054057285,-0.004360324,-0.050922707,-0.05784305,-0.06197834,-0.011184169,-0.02848497,0.008272965,0.046775162,0.041939065,0.034452654,-0.009811233,0.022289526,-0.030629473,0.082994446,-0.06660482,-0.07045921,0.034828324,0.035385415,0.027405724,-0.030583514,-0.10083535,-0.049979143,0.016697973,0.24420145,0.05593885 +4.2.3.34,"This enzyme catalyses the committed step in the biosynthesis of the stemodane family of diterpenoid secondary metabolites, some of which possess mild antiviral activity. The enzyme also produces stemod-12-ene and stemar-13-ene as minor products.",384,0.99999994,-0.07395473,0.03031633,-0.05695649,-0.076705754,0.029486869,0.008537099,-0.10742348,0.13532643,0.03613008,0.09236101,0.018822012,-0.016940152,-0.054711018,-0.032723412,-0.01085785,0.01593597,-0.12487358,0.045345727,-0.031981852,-0.0006041768,0.059385452,0.025767421,0.00087698124,0.01752957,0.016546475,0.029524704,0.081389196,0.026160417,0.0428852,-0.049483426,0.04657796,0.0043362607,0.028227413,-0.045211095,-0.021116626,0.03733497,-0.036729414,-0.021835167,0.032859035,-0.006757379,0.04146759,0.02129482,0.012479949,-0.037766192,0.065652385,-0.08059664,-0.048170898,0.025141934,0.025117457,-0.046576492,0.034393616,-0.050625134,-0.01909953,0.089305505,0.019395426,0.01756766,-0.03794085,-0.044369146,-0.008289874,0.08238514,0.09411306,-0.0031263647,-0.04200363,-0.06995511,-0.12945491,-0.08995339,0.020335576,0.018168828,-0.0077567375,-0.053789288,-0.04055551,-0.08221929,-0.08741083,-0.02590801,-0.079286605,0.019254556,-0.0010760301,0.038189966,0.010795525,-0.029698158,0.020638779,-0.027919479,0.036688816,0.10568286,0.05031281,0.009597986,-0.011736127,0.03096573,0.07051472,0.060268324,-0.002864787,-0.029691469,0.033863813,-0.024609873,-0.0539455,0.072463505,0.007824587,-0.02103639,0.007148746,0.054805066,-0.0036997974,0.015283835,-0.08774244,-0.09006568,-0.08226172,0.0007318663,0.01429923,0.043726906,0.027270315,3.0030784e-05,-0.003344123,-0.0357589,0.047799956,0.06263566,-0.032251053,0.06505604,-0.015584416,-0.08098434,0.013701915,-0.03923106,0.018530857,0.031013079,0.104197614,0.056175303,-0.067888185,-0.05029045,0.00033685248,6.6765503e-34,0.07181994,0.01949789,-0.019591296,0.0088806,0.027900765,0.057140697,-0.067198694,0.06888698,-0.073968224,-0.098690644,-0.09735418,-0.07063667,0.05488791,0.01739267,-0.04750066,-0.08762367,0.008888219,0.048243772,0.011842844,0.012850891,0.030530335,-0.051871266,-0.048229918,-0.020974979,0.01825679,0.020494176,-0.08616097,0.016539177,0.047304954,-0.024199115,-0.011406126,-0.04656488,-0.016609522,-0.0057202103,0.04705203,-0.04574271,-0.014768263,-0.043778047,-0.02982882,0.0199807,0.06663917,0.0031805616,-7.62333e-05,-0.008309085,0.043149367,0.009140637,-0.037604135,0.02737094,0.072741374,-0.0043040514,0.024926824,0.028368192,0.07102655,-0.0057115983,-0.06869568,0.089646146,-0.011598519,0.0130632715,0.05460576,-0.0014000438,-0.05006924,0.049726058,-0.054602355,0.06593597,-0.05541629,-0.013090598,-0.043390945,0.009264887,-0.041952625,0.12742752,-0.027743518,-0.0023713775,-0.016016968,-0.01808262,0.04835274,0.04044507,-0.04452926,0.052589066,-0.0038999876,0.020761304,-0.052022103,-0.023460671,-0.035571877,-0.044359438,0.022242269,-0.009553267,-0.08974002,-0.08683512,0.02781329,0.049070302,0.01001209,-0.074041195,-0.06724581,0.018724876,0.025063267,-1.7911127e-33,0.014522411,-0.053507358,0.015100489,-0.10684934,-0.018222487,0.129985,0.0068382043,-0.0644001,0.03884029,-0.040614743,0.027137518,0.016191844,0.042579155,-0.0062775165,-0.010537953,-0.0029275215,0.054237556,0.09058959,0.015259405,-0.05667263,0.053788062,0.06400188,-0.07381317,0.010051426,0.047515538,-0.020414617,-0.0058437367,0.103067875,-0.0073405476,0.1076267,0.054377943,-0.054656707,-0.019780334,0.03785107,-0.025368381,0.09852307,-0.03126525,-0.06863367,0.032511514,0.026638307,-0.021367408,-0.010058001,0.007870744,0.05890582,0.035684366,-0.010330299,-0.06096759,0.07452546,0.018166136,-0.05647976,0.055295754,0.026962934,0.02088622,0.038038228,0.013697593,-0.034263328,-0.022768265,-0.02992158,-0.01287371,-0.023342421,0.011272815,-0.08375567,0.008429922,-0.05591874,0.007481992,0.04114654,-0.039105058,0.050624035,0.040367693,-0.027122894,0.07698968,0.038150016,-0.012612007,0.02474635,-0.040695228,-0.02695985,-0.025020186,-0.14332695,0.01061371,-0.041592382,-0.059238855,-0.04194573,-0.010140791,-0.110536486,-0.08085663,-0.07208773,0.013829924,0.055977847,0.023161018,0.06787959,-0.027490072,0.020357305,-0.040280044,0.13054366,0.040972866,-3.043583e-08,0.044536285,-0.07058705,-0.007610876,0.004719631,-0.012947203,-0.027771117,-0.011821071,-0.025277304,0.0058684535,-0.056878213,0.007213174,0.025421336,-0.020450003,0.0395321,0.113111876,0.050637368,0.06291394,0.041237075,-0.04280676,-0.0566822,0.037956726,0.0373731,-0.005806724,-0.045467574,-0.05914017,-0.08501122,0.008986294,-0.0040826746,0.04839103,-0.018150004,0.036074217,0.048285894,-0.005138208,0.021466115,-0.067515396,0.07934861,-0.0046265693,-0.028934356,0.023471793,0.0048378212,0.088045634,-0.070779204,-0.095448084,0.021991786,-0.076209106,0.048666116,0.01701602,0.02993204,0.0066768,0.0031810505,0.028033713,0.05825803,0.039382614,0.0062610935,-0.09963352,0.067119464,-0.02159859,-0.025911331,0.0014326384,-0.07219816,-0.008048937,0.024190243,0.25238594,0.02198637 +4.2.3.35,"This enzyme is a class I terpene synthase [1]. 9beta-Pimara-7,15-diene is a precursor of momilactones A and B, rice diterpenoid phytoalexins that are produced in response to attack (by a pathogen, elicitor or UV irradiation) and are involved in the defense mechanism of the plant. Momilactone B can also act as an allochemical, being constitutively produced in the root of the plant and secreted to the rhizosphere where it suppresses the growth of neighbouring plants and soil microorganisms [1].",384,0.99999994,-0.076497175,-0.048572898,-0.110303186,0.039401677,0.053040717,0.09423473,-0.06580351,0.085623376,0.05217942,0.02655679,0.093896076,-0.04499336,-0.0130905,-0.011717871,-0.07644488,0.06700212,-0.06498756,0.009532889,-0.041203186,-0.012398886,0.037807316,0.1166813,-0.00918872,-0.0016336717,0.034175042,0.03230762,0.04025147,0.021087954,0.039115474,-0.06298298,-0.07449399,-0.020032883,0.015211133,0.012724252,-0.025174625,0.08403853,-0.053785376,-0.076887585,0.06548434,0.0037480518,0.049345087,-0.016860332,0.042707,-0.059584524,-0.06281573,-0.026286982,-0.037138358,-0.008338536,0.007549604,-0.057874788,-0.023048721,-0.07530895,-0.037420142,0.060494088,-0.019550474,-0.07628297,0.027177181,0.019075489,-0.039152384,0.03540461,0.025279507,0.05014919,-0.024343366,-0.003447644,-0.008222764,-0.042431906,-0.012010553,0.032117017,0.03093973,-0.067408934,0.005309941,-0.03270867,-0.0631838,0.093961954,0.03455672,0.04629528,-0.03131149,0.022969894,-0.02271981,-0.022694377,0.03130978,0.06432817,0.077506155,0.109395824,0.0599207,0.024992475,-0.02806468,0.047488973,0.12373031,0.019459067,0.028917829,0.043606173,-0.056500155,0.04066695,-0.052581035,0.09292185,0.0123003675,-0.0354484,-0.064484656,-0.027486525,-0.012682999,-0.030491915,-0.18813941,0.010928829,-0.0378637,-0.0037936338,-0.02281551,-0.028056918,-0.001160905,-0.020692224,0.036011655,-0.0038301847,-0.045382187,-0.045011405,-0.07316285,0.003516353,0.041685533,-0.08965801,-0.038526237,-0.03673282,0.0044333404,-0.008917786,0.005454292,0.0010499045,-0.07007875,-0.0574168,-0.06629005,1.6468426e-33,0.057847433,0.060319662,-0.0612647,-0.012344363,0.008387397,-0.038472854,-0.021706726,0.03278147,-0.041123636,-0.037362132,-0.13062295,-0.028260097,-0.037667576,-0.04470946,0.025855307,0.022675777,0.007846458,0.008278546,0.089584626,-0.026868671,-0.008617551,0.065779366,-0.037847556,-0.08356978,0.0048423484,0.031458892,0.055452537,-0.01585104,0.042097084,-0.030491747,-0.007724249,-0.065304,-0.05098034,-0.053217493,0.028021121,-0.046146773,-0.07523288,-0.021698045,-0.07674077,0.040074155,-0.0019111449,0.031183576,-0.04355,-0.0012655806,0.1341281,0.015057493,-0.08256747,0.060101166,0.055515684,0.023356028,0.060546607,0.023335263,0.08658781,0.06927801,-0.06728661,0.035554126,0.024204168,-0.020425443,-0.017614212,0.113221854,0.003828683,-0.008605672,-0.015166606,0.06723871,-0.04943068,0.0006109179,-0.10394958,-0.0017272023,0.013334595,0.09231523,-0.040859614,-0.082582586,0.033032097,-0.029101353,0.0028170145,-0.016215345,-0.032506738,0.03895993,-0.005513171,-0.027661527,0.007393027,-0.04217929,0.029242698,-0.0366018,-0.09995092,0.011348199,-0.030289594,-0.043181017,0.008410368,0.018325249,0.057063337,-0.028428173,-0.011697053,0.0008116488,-0.046544813,-3.3776555e-33,0.04719777,-0.013476735,0.023883997,-0.06963821,-0.014941784,-0.027880609,-0.052964818,0.015252594,0.021893356,0.06470603,0.07444381,-0.020651432,0.05773778,-0.014792614,-0.006163107,0.014916779,0.04273361,0.08273213,-0.021567311,-0.06116721,-0.089555316,0.11385534,-0.014875737,0.009703958,-0.0034670203,-0.030525276,0.026910324,0.12034345,0.008758066,0.07807142,0.08348005,-0.047502965,-0.011601049,0.05909042,-0.09065327,0.09501134,-0.020982418,-0.056451052,0.039605293,0.04628127,0.041924357,-0.054774802,-0.0046356223,0.09445657,-0.00017334556,0.044973727,-0.11627493,0.080364764,0.027344799,-0.06077821,0.039716497,0.013706953,0.014478753,0.009879747,-0.009664839,-0.011026908,0.009997438,-0.006120758,-0.0056130844,-0.032624684,0.062242705,-0.061189275,-0.013289142,-0.015861908,0.0131685855,0.02284694,-0.018591339,0.043958448,0.07225632,0.06131172,0.05484097,0.075364925,-0.010689795,0.031734463,-0.056733422,-0.029247288,0.017504368,-0.044437435,0.016607521,-0.0038357808,-0.044751007,-0.024023548,0.030812403,-0.11242725,0.023609214,-0.09263694,0.076175064,0.06956771,0.061632384,0.0537406,0.012572117,0.0134111885,-0.023719732,0.03547096,0.060652144,-4.3347892e-08,0.062011708,-0.11433772,0.0010349269,-0.0036061055,-0.09176133,-0.096405976,0.04231414,-0.0024699855,0.060970988,0.02127123,-0.06970202,0.045242593,-0.0010956497,0.007374583,0.065988325,0.0037165564,0.0029428788,0.041104406,-0.03117884,-0.054531775,-0.019827753,-0.028046085,-0.013137858,-0.012976116,-0.0041579176,-0.07799036,-0.0098757455,0.04662589,0.012164427,0.003866587,0.0520409,0.04127609,0.024167001,-0.0045953775,-0.07510543,0.08630775,0.0034970418,-0.027582055,0.0053150808,0.009175847,-0.030055478,-0.037479684,-0.08904179,0.028426819,-0.04130187,0.011231669,-0.015180331,0.027083972,0.0790018,0.015880657,0.009429062,-0.021841194,0.03162719,-0.05490078,-0.06666382,-0.007956427,-0.03634995,0.01074294,-0.024780633,-0.068669714,0.009805357,-0.008856407,0.22500518,-0.011482185 +5.5.1.14,"Requires a divalent metal ion, preferably Mg2+, for activity. This class II terpene synthase produces syn-copalyl diphosphate, a precursor of several rice phytoalexins, including oryzalexin S and momilactones A and B. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme is constitutively expressed in the roots of plants where one of its products, momilactone B, acts as an allelochemical (a molecule released into the environment to suppress the growth of neighbouring plants). In other tissues the enzyme is upregulated by conditions that stimulate the biosynthesis of phytoalexins.",384,1.0,-0.053100593,-0.100711316,-0.034067415,0.06641671,0.07511457,0.060390275,-0.06642097,0.0747953,0.046999756,0.033801366,0.14322901,-0.028836252,0.04540569,0.020461844,-0.046559427,0.06175738,-0.060699034,0.046152953,-0.05041282,-0.008158013,0.06409391,0.09812783,-0.02740846,0.012459729,0.004854614,-0.004812628,-0.010996864,0.032823645,0.02453921,-0.041404292,-0.10507528,-0.018562619,-0.050149772,-0.035674453,-0.036235284,0.05412665,-0.045709897,-0.031255443,0.046043128,-0.048681032,0.045186445,-0.06277958,0.011128533,-0.05639427,-0.026589746,-0.06111073,0.029100437,-0.0544214,0.028827868,-0.072751135,-0.019773211,-0.038430568,-0.0038287146,0.06117704,-0.043452043,-0.03071399,0.030012691,0.022067275,-0.015357666,0.06669175,-0.014469152,-0.0041866945,-0.026360214,-0.0168984,0.03334933,0.0013306226,-0.051289197,0.0095019,0.029233143,-0.06449724,-0.023583764,-0.048555553,-0.023883685,0.07234725,0.0226018,0.06284838,-0.01608907,0.080584146,-0.008655681,-0.044205774,0.06045462,0.047699846,0.06802583,0.11126638,0.06793269,-0.013961847,-0.010628032,0.064462,0.05170957,0.03676145,0.08187573,0.03512539,0.0021516762,0.03044517,-0.038710605,0.071438976,0.026586423,-0.032020338,-0.009636382,-0.028218856,-0.006575107,-0.027852109,-0.17212981,0.016955866,0.043148886,0.0007976514,-0.012242165,-0.03968175,-0.017819153,0.008098437,0.06501324,-0.02090484,-0.046084445,-0.01305579,-0.014416359,0.0422788,0.0243786,-0.04571394,-0.015748275,-0.05598136,0.019916285,-0.0026846242,0.00058382674,0.024202986,-0.059720557,-0.041959617,-0.05033052,4.2034885e-33,0.054847926,0.08467795,-0.029421657,0.0010160841,0.010758295,-0.040286917,-0.03329435,0.026356539,0.018644864,-0.034247488,-0.115510374,-0.039859716,-0.04284894,-0.0099764755,0.034501396,0.0013538299,-0.025560876,-0.01753427,0.09704345,0.00068942265,-0.030565366,0.051591523,-0.052362937,-0.03202961,0.03351237,0.032766346,0.012998166,-0.04405208,0.027165445,-0.024736283,0.061318424,-0.111976385,-0.03752952,-0.025025157,0.02784416,-0.05340479,-0.03229988,-0.019223139,-0.06685448,0.020489663,-0.05795507,0.07000405,-0.07733621,-0.025531005,0.13214889,-0.03235661,-0.07864245,0.08036448,-0.01821054,0.013833009,0.059057623,0.02589915,0.062891535,0.046974264,-0.028856477,0.004379204,0.037983265,-0.035338085,-0.019758806,0.10834952,-0.004268942,-0.037411377,0.00087114197,0.043895807,-0.03560576,0.02351225,-0.11916841,-0.060350623,-0.015760174,0.050241716,-0.022548676,-0.067413926,0.013471239,-0.03872496,0.003101447,-0.015733743,-0.060734157,0.05075313,-0.018569624,0.0042212754,0.030406421,-0.03146872,0.013022372,-0.0001496547,-0.088734925,-0.008048069,-0.034224078,-0.041013543,0.014452867,-0.011813491,0.06444646,-0.0019945863,-0.03210822,0.012721524,-0.040654503,-4.4364498e-33,0.10953698,-0.010866295,0.08177758,-0.09101734,-0.06136572,0.0033824667,-0.06641453,0.029768355,0.03502291,0.023980664,0.040542495,0.020108992,0.041850146,-0.021772075,-0.08322832,-0.0017806648,0.01976823,0.1318642,-0.0046209535,-0.05725577,-0.066987224,0.12626186,0.05045996,0.013898141,0.019213386,-0.016502136,-0.014192982,0.08494569,-0.008950506,0.11840263,0.039870083,-0.019583007,-0.031987227,0.0020730293,-0.03881338,0.08004522,-0.015386872,-0.053803273,0.006190162,0.13185383,0.017281152,-0.047221266,0.036658242,0.041638825,-0.018594764,0.03964715,-0.12003401,0.06290961,0.018186375,-0.06177258,0.043435745,-0.006793223,1.6129261e-05,0.044433426,-0.005947029,-0.027861135,0.058174398,-0.02082957,-0.013076312,-0.024840739,0.05445006,-0.044683162,-0.018336486,-0.020890193,-0.045759853,0.05316176,-0.042541698,0.07371796,0.07213275,0.031454746,0.008638783,0.04772441,0.016322538,-0.020333836,-0.05288806,0.053029,-0.006318925,-0.05470412,0.01243113,0.0033985765,-0.03851543,0.025349472,0.010183936,-0.08149966,-0.027575394,-0.049574837,0.063468315,0.14178427,0.03194805,0.0037014254,-0.013681403,-0.027320437,-0.04642538,0.08371635,0.09929084,-4.7071335e-08,0.0123705715,-0.08081551,0.020409288,-0.037651733,-0.08592963,-0.037527386,0.013827933,0.0024835605,0.06353994,0.008208891,-0.08284621,0.06328022,-0.030472126,0.024609763,0.050412573,0.055172227,0.06550111,0.020608572,-0.03179579,-0.08478714,-0.011363432,-0.06268038,-0.05075565,0.023037655,-0.0022684804,-0.08721652,-0.015243365,0.026105618,0.0082794735,0.020128364,0.07136659,0.011369466,-0.0018314223,-0.061239477,-0.075337544,0.07280571,-0.034399424,-0.08232446,0.0036561769,-0.0050676945,-0.06308436,-0.051206067,-0.075187005,0.0022984794,0.024699643,0.0073112105,0.014438508,0.06499423,0.03976564,-0.004903136,0.011873497,-0.0673812,0.034575686,-0.07707203,-0.08855314,0.028715068,0.028502828,0.02248983,-0.020271452,-0.08051772,-0.0002505775,0.026309898,0.22176728,-0.027757281 +1.1.1.296,"This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (-)-isodihydrocarveol.",384,1.0,-0.04337076,-0.02167079,-0.08439728,-0.032202985,0.0386188,0.02125249,-0.13727112,0.02427793,-0.01089316,-0.02228738,-0.0014146408,-0.037463546,-0.06963223,0.055263005,-0.025382677,-0.036122438,-0.0683406,0.051239897,0.012250406,0.0021775905,0.083770305,-0.02390732,-0.10448501,-0.024657242,0.047540158,0.015906375,0.08010403,-0.04058615,-0.026150106,-0.08590006,0.04690028,-0.113287084,0.14064246,-0.06350856,0.064017184,0.07600113,-0.039156094,-0.056196805,0.08075692,-0.019551408,-0.03421474,-0.017153122,0.00940032,-0.006567731,-0.057651203,-0.0069924924,-0.033481527,0.039960667,0.08795438,-0.03799891,-0.005874943,0.0052497564,-0.055737477,0.048102617,0.017667765,0.037293483,-0.010314488,0.0021530406,0.0029642892,0.016999537,0.08061892,-0.0036093278,-0.018976562,0.0036025164,-0.08335212,-0.059745964,0.053940408,-0.06723902,-0.0023579893,0.059213027,-0.06459564,-0.05495277,-0.019804638,-0.0026010731,0.007571708,0.06557965,0.0025218176,-0.04574518,0.08283204,-0.032592017,0.066163085,0.036354877,-0.006941636,0.05544923,0.005974198,-0.0036152303,-0.007431241,-0.07490336,0.033970304,0.038191307,0.016308023,-0.024803635,0.003952088,-0.081438795,-0.015840016,0.019286195,0.021138916,0.05628683,0.0018115147,-0.041600928,0.0448264,0.020445507,-0.035818417,-0.12197935,-0.09473966,0.02304463,-0.06991694,0.08447702,0.0688313,-0.009763767,0.016011275,0.054755382,0.023319826,-0.016141778,-0.04517977,0.047965754,-0.0027744763,-0.05453165,-0.10998122,0.018973159,-0.017814284,-0.04680883,0.064870395,0.0049031978,-0.025795886,-0.033037383,-0.0100513995,4.4720136e-33,0.007173188,0.0048223156,-0.032416154,-0.034111563,0.011836616,0.01619003,-0.10077583,0.084766366,-0.006220003,-0.061254557,-0.023957858,-0.048701752,-0.013190006,0.020350933,-0.097008616,0.059026763,0.0009100866,0.0058040614,-0.016552374,0.006632891,-0.028390488,0.03782563,-0.02791282,-0.013534033,0.049014032,0.06308502,-0.011307765,-0.00530821,0.036029074,-0.014552084,0.0791089,-0.096031964,-0.11393199,0.07323146,0.04306571,0.016026992,-0.019953655,0.00018636152,0.033148926,-0.03576352,0.06200521,0.09552332,-0.036428895,0.005494419,0.08152048,-0.025202602,0.034848616,0.07172134,0.0075997063,0.082348585,0.03202916,0.005274659,0.024775766,-0.04819969,-0.031710997,-0.004736012,-0.009493001,0.059266437,0.049229734,0.018384648,0.045848858,0.15637232,0.037666693,-0.048745826,0.021102572,0.012581592,-0.042575177,-0.06765182,-0.017095223,0.06148557,8.6133456e-05,0.03496361,0.0125534935,0.04998551,0.027747903,-0.05674384,-0.04235856,0.036538582,0.094118364,-0.040997684,-0.05919047,0.036250662,0.012331388,-0.04689239,-0.033444025,-0.015518521,-0.03443355,-0.041360848,-0.04580325,0.06842395,0.033547297,-0.111309856,-0.05027482,0.09379953,0.011141813,-5.9582488e-33,0.06720477,-0.11569768,0.03055123,-0.0949254,-0.030418688,0.051060252,0.024353553,0.04290938,-0.030173022,-0.03822024,0.11524232,0.04177632,0.0407411,0.08272599,0.07683375,-0.03806294,-0.0012264287,0.048146658,-0.076982595,-0.019532438,-0.005815056,0.092073575,0.033730764,0.06900862,0.049275793,-0.023245167,0.009134957,0.060328655,0.039530568,0.0734649,0.07178583,0.029027976,-0.049053896,-0.011578115,-0.06126922,0.061444778,-0.06644318,0.021978868,-0.01150257,-0.0052458765,0.029146781,0.06070373,-0.04636537,-0.03581441,-0.0033914214,0.05953572,-0.05761631,0.013337359,0.006082072,0.0044409824,0.015912877,0.016416334,-0.09451587,0.004200359,0.005899288,0.067119345,-0.047414687,0.000564424,-0.0435874,-0.021895533,-0.14022565,-0.03722521,0.015467174,-0.0061529735,0.05016537,0.08281833,0.034189627,0.08143296,-0.022804268,-0.056777902,0.1268404,0.016643668,-0.014530923,0.043743618,-0.04513473,-0.052115835,-0.008276388,-0.022885824,-0.007415863,-0.036320716,0.03521246,-0.05674925,0.009935339,-0.0058843014,-0.038463876,-0.088291176,-0.0005582565,0.057827245,-0.0006667332,0.11625831,0.032872,-0.021783674,-0.0838389,0.07021546,0.1116105,-4.3901213e-08,0.05222093,-0.03668395,0.07235205,-0.09416814,0.0012727532,-0.0046721324,0.0007139447,0.018601133,0.024277305,-0.02879646,0.0058797416,0.07282496,-0.04676957,0.010612658,0.029507596,0.037777267,-0.063260704,0.031410124,0.015409342,0.036536608,-0.055747554,-0.0589643,-0.06971768,0.014725456,0.033185884,-0.068573385,0.07822389,-0.032437723,-0.01632896,-0.058351036,0.023739344,0.08234803,-0.006426748,0.03875282,-0.061238274,-0.04520874,-0.06884599,0.025137322,-0.066316165,0.035401314,0.005644283,-1.0038015e-05,-0.084532134,-0.024570817,-0.0044396827,0.039566673,0.020952785,0.008588419,-0.020078901,0.0058451914,-0.023947306,-0.009475,0.0073520564,-0.07123924,-0.09062285,-0.032412026,-0.046493094,-0.01844133,-0.025039734,-0.002062351,0.008745327,0.018933741,0.1511978,0.0013254676 +1.1.1.297,"While the enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate.",384,0.99999994,-0.061522257,-0.07517605,-0.057515725,-0.038382422,0.023618758,0.024647856,-0.07408234,0.090307154,-0.0015132657,0.0022894894,0.012480373,-0.05711714,-0.018149678,0.118389815,-0.0145032285,-0.02820263,0.0005508436,0.03142268,-0.017179875,0.01587752,0.09767328,-0.039877903,-0.09491109,-0.011620673,0.037130766,-0.0050017457,0.06930549,-0.023591952,-0.007387015,-0.0876361,0.054116424,-0.071729265,0.10851854,-0.050737925,0.033764135,0.06438182,-0.010262085,-0.069350004,0.09012118,-0.0016077302,-0.008538216,0.00299044,0.07225437,-0.010147034,-0.083183795,-0.008576615,-0.027946291,0.054551635,0.09562626,-0.043101255,0.019149667,0.028913124,-0.06934028,0.033270452,0.012446612,0.033853225,-0.075051814,0.038174238,-0.026491838,0.021684734,0.048474886,-0.015797151,-0.0018248083,-0.0023656073,-0.06968595,-0.09247375,0.056247775,-0.07725551,-0.022250159,0.050630067,-0.062344167,-0.02987287,-0.017607186,0.00026637147,0.015807275,0.05037357,0.030160122,-0.029559288,0.08360737,-0.0648349,0.02618417,0.015675312,0.01573265,0.08057778,0.027823566,-0.0014965099,-0.007556026,-0.073280744,0.075108774,0.027263809,0.07784877,-0.029468972,-0.015140557,-0.07368406,-0.058772434,0.024649296,-0.026767818,0.08245837,-0.008605447,-0.02669364,0.030680057,0.0363809,-0.00064704753,-0.08545795,-0.049375057,-0.038457736,-0.031213135,0.0673327,0.056776676,-0.017995693,0.053046796,0.033593863,0.010312711,0.023515712,-0.032220736,0.007023131,0.030091783,-0.104000755,-0.10768979,-0.034862585,-0.025747925,-0.10003004,0.075335085,-0.045604374,-0.03391976,-0.029707814,-0.0132875,1.5487781e-33,0.0037548859,-0.02169012,-0.0058732764,-0.026872689,0.023193276,0.039546,-0.10285892,0.07300644,-0.0078379,-0.086496085,-0.028366031,-0.026448878,0.062186178,0.030067718,-0.0622983,0.059526294,0.037578933,-0.03286005,0.022862587,0.006107888,-0.0057657887,0.016288009,-0.0113732545,0.008829118,0.07531647,0.015316583,0.014928518,-0.02133402,0.02520881,-0.017848603,0.061393123,-0.09433404,-0.06459652,0.12107137,0.029409835,-0.0019595863,-0.021244653,-0.019828694,0.066692434,-0.09308929,0.044935226,0.12586096,-0.013865957,-0.008246297,0.044370174,-0.030830694,-0.026569325,0.045603618,-0.016977103,0.09898918,0.042058658,0.035577133,0.05672368,-0.059805572,0.0143452445,-0.012904453,0.0046986635,0.07720614,0.080890514,0.052408334,-0.0077298842,0.14350134,0.0020486068,-0.018524121,0.08041894,0.055983208,-0.024890095,-0.068057165,-0.007082186,0.06736813,0.012558876,-0.0014969957,0.030487744,0.022651104,0.022261253,-0.06559498,-0.0058350754,0.04904339,0.086469345,0.023798,-0.0042816172,-0.0051574335,0.019013809,0.017885542,-0.11255381,-0.024099762,-0.0045948834,-0.0250749,-0.027436117,0.05146435,0.07743766,-0.07407789,-0.051962264,0.05788509,0.021516215,-3.283727e-33,0.05488944,-0.062278938,0.004108034,-0.05803777,-0.025827475,0.03607162,0.054076895,-0.019742718,0.0348912,-0.021029465,0.18127756,0.02523488,-0.03840181,0.0900563,0.050752435,-0.029420324,-0.05596166,0.07504117,-0.0488481,0.013256461,-0.017711297,0.1001447,0.030644542,0.05275861,0.064767286,-0.050894313,-0.026114954,0.05885947,-0.008368428,0.056969494,0.048008718,0.041267354,0.008270427,-0.0029587888,-0.06783733,-0.026210783,-0.03512652,-0.004869255,-0.0009979056,0.016511934,0.07459806,0.06520041,0.008175227,0.02821857,-0.040411234,0.046686787,-0.03917103,0.024256183,-0.006025676,-0.047572117,-0.024843398,-0.013320762,-0.100527644,0.0052792435,0.010984915,0.034729254,-0.007855287,-0.0017868285,-0.08011219,-0.04989171,-0.12880579,-0.02745452,-0.02292068,-0.029568145,0.018141963,0.07034277,-0.043705497,0.052913412,-0.0041507413,-0.08529564,0.10243985,-0.016268393,0.05121419,-0.024392568,-0.11813111,-0.072623804,-0.016138738,-0.044872995,-0.0044213063,-0.025601974,-0.026563887,-0.0028018884,-0.044609252,-0.04026764,-0.049327325,-0.08535217,0.0022199284,0.03539099,-0.03285652,0.07341946,0.02423927,-0.031101074,-0.03261721,0.08622516,0.08388879,-4.47304e-08,0.016278213,-0.020492023,0.058030196,-0.085409455,-0.01387381,0.032597486,-0.005055534,0.03837286,0.027544513,0.040457416,0.017008305,0.06514224,-0.07537305,0.0030000142,0.06979073,0.058851678,-0.08518239,-0.01797045,-0.017245471,0.011129231,0.014129687,-0.0788718,-0.0448691,0.009692525,0.018991966,-0.050250106,0.011511656,-0.06020666,-0.045464672,-0.08307348,0.02775291,0.048949648,-0.020428834,0.0051336987,-0.04927329,-0.06503442,-0.044145454,0.026952462,-0.06518036,0.054281756,0.023755638,-0.020015636,-0.09531655,0.016207658,-0.008927078,0.018209564,0.023914043,-0.025107427,-0.016042067,-0.043352045,-0.03477301,-0.025717473,0.0331886,-0.095871344,-0.073879346,0.0076524764,-0.06267305,-0.018408705,-0.06166915,0.03347092,0.038002953,0.035803687,0.12854327,-0.00029292004 +1.3.99.25,"This enzyme participates in the carveol and dihydrocarveol degradation pathway of the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme has not been purified, and requires an unknown cofactor, which is different from NAD+, NADP+ or a flavin.",384,1.0,-0.09264402,-0.017626936,-0.094188355,0.005668365,0.07492804,0.060880814,-0.1322839,0.043124277,0.013776207,-0.008034397,-0.030119292,-0.028560381,-0.056708828,0.04618165,-0.073243484,-0.0089846905,-0.056462977,0.012119247,-0.009678522,-0.014165984,0.055558443,0.011189597,-0.054583568,0.0046699815,0.04750704,0.020383898,0.07310624,-0.047838762,-0.033319093,-0.06543712,0.022589061,-0.068734564,0.072638586,-0.038612586,0.053343043,0.099905774,-0.02971593,-0.06550526,0.07586276,-0.014204051,-0.028690549,0.013730872,-0.0038738616,-0.007395646,-0.033430804,0.000111813664,-0.032801628,0.09332749,0.053052895,-0.027209213,-0.03265939,0.017511714,-0.032704048,0.014149156,0.013558044,0.03598494,-0.022545407,-0.017431729,-0.017170532,-0.0007634399,0.069159344,-0.032178268,-0.04215706,0.012954561,-0.046623398,-0.067845315,0.06369427,-0.04971298,0.0098480135,0.022627957,-0.10411793,-0.040372644,0.013701435,0.020214742,0.0117577175,0.048111755,0.006049844,-0.04087974,0.11321997,-0.02746969,0.09590304,0.04755903,-0.004671249,0.055113826,0.03179372,-0.00028333126,0.027877867,-0.06905437,0.018357186,0.038599472,0.04362636,-0.04221001,-0.007674572,-0.037151065,-0.11684659,0.028741822,0.052861672,0.0024252112,0.004694768,-0.034587357,0.013724325,0.06930183,0.059693463,-0.10285358,-0.09013283,0.020596283,-0.060748834,0.10195534,0.0677926,-0.016178515,0.025529904,0.042172838,0.017459473,-0.018909544,-0.048259955,0.102705866,-0.010551246,-0.0804221,-0.1331456,-0.028147113,-0.018284777,-0.096757375,0.012401268,0.00025523527,-0.035245284,-0.02531126,-0.058647886,1.9767363e-33,0.035678223,-0.046972252,-0.052657858,-0.021492833,0.029558796,0.009080855,-0.07881745,0.08862244,0.008172373,-0.071984455,0.021809427,-0.06613873,0.016314004,-0.0070020617,-0.10269215,0.053245146,-0.037361618,-0.06649297,-0.014563453,0.010073375,0.018960586,0.058635037,-0.018898878,-0.0031020965,0.0463526,0.08525686,-0.02348093,0.005126008,-0.014485329,0.0053657894,0.06845967,-0.10489129,-0.101242244,0.08667928,0.05587937,0.013022508,-0.040455803,-0.07161431,0.037581913,-0.029506564,0.0052874098,0.06690485,-0.044680037,-0.0018643375,0.032526687,-0.08545792,0.021152604,0.064649805,-0.011319895,0.11564296,0.06580683,-0.009038205,0.0736521,-0.031429086,-0.030796178,0.004948221,-0.017416034,-0.001926224,0.032690182,0.010640622,0.038537975,0.11075062,-0.007693146,0.0079427725,0.03456372,0.024408937,-0.054143254,-0.08489698,0.04443891,0.061282665,0.020427318,0.04650001,0.016703375,0.016164012,0.007053412,-0.03562262,-0.008643792,0.044032495,0.0423119,-0.017200124,-0.032457467,-0.0037647367,0.034886014,-0.014520061,-0.020920284,0.0052540144,0.0022398431,-0.046260014,-0.07053931,0.028857782,0.05972141,-0.08352763,-0.008153064,0.06045934,0.034276713,-3.2497056e-33,0.09100593,-0.10830254,0.024209224,-0.07968289,-0.045647357,0.048465673,0.007145561,-0.005071541,-0.014071839,-0.07441961,0.08632547,0.03891822,0.04522317,0.090900056,0.11203258,0.0045900377,-0.015216408,0.024649112,-0.09548376,0.0024122198,-0.011319693,0.10677581,0.04278779,0.029524945,0.042556215,-0.04947075,-0.030619027,0.021336671,0.016509334,0.04055962,0.043259893,0.04212338,-0.04314099,-0.030736195,-0.057558615,0.01310324,-0.042337943,-0.0073443023,-0.018677657,-0.005555138,0.089894,0.054314964,-0.061679106,-0.033091165,0.014454629,0.06963518,-0.09404347,0.02080014,0.05042243,-0.013732954,0.04196572,0.04686574,-0.03925001,0.0449348,0.016638529,0.08325348,-5.399006e-05,0.006781331,-0.048290946,-0.0052831057,-0.13192394,-0.036765043,0.003940037,0.037667926,0.098498,0.04759938,0.017981725,0.09570848,0.02111149,-0.04796866,0.1245108,0.048648022,-0.0040047094,0.042070862,-0.07267429,-0.04941691,-0.05720581,0.00016894637,-0.014030234,0.00537645,0.029706402,-0.023239244,0.019368306,-0.048936516,-0.05110904,-0.07513392,-0.038333382,0.0536321,0.0028524466,0.073586665,0.037994407,-0.02493142,-0.08882974,0.041603323,0.07531537,-3.2545692e-08,0.029618714,-0.021524435,0.041156806,-0.07380832,0.028007107,0.029418366,0.04506169,0.027068984,0.009829616,0.02161884,0.026186746,0.08522888,-0.042961933,0.0028248425,0.0045819287,0.003478773,-0.080582365,0.0149726,-0.0097919125,0.029569833,-0.043368924,-0.0751845,-0.068138056,0.07901735,0.05567869,-0.07774557,0.06490281,-0.039865445,-0.019024698,-0.07285976,-0.0048494986,0.060641866,0.035313573,-0.0012884535,-0.07970178,-0.008905664,-0.005553843,0.007273994,-0.09031359,0.08003599,0.0005302153,0.0444448,-0.0796644,-0.018428495,-0.02411972,0.047089793,0.024190206,-0.04852127,0.0059063393,-0.0034201448,-0.027102193,-0.010629818,-0.004923897,-0.05645599,-0.114229545,-0.02999841,-0.024189945,0.0035127013,-0.011039174,-0.014096445,0.021979958,0.05369721,0.14560986,0.011524238 +1.14.13.105,"A flavoprotein (FAD). This Baeyer-Villiger monooxygenase enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 has wide substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones [2]. Both (1R,4S)- and (1S,4R)-1-hydroxymenth-8-en-2-one are metabolized, with the lactone product spontaneously rearranging to form 3-isopropenyl-6-oxoheptanoate [1]. ",384,0.99999994,-0.04499465,-0.06381447,-0.062144566,0.03776115,0.056172967,0.08470937,-0.11927285,0.03213574,0.009278111,-0.025453236,0.0026207299,-0.045941178,-0.0337615,-0.0024049522,-0.075904645,0.03275768,-0.06166894,0.04518649,-0.012557503,0.050708946,0.009980705,-0.024018593,-0.000860084,0.025589341,0.10688315,0.02387643,0.07235838,-0.056550432,-0.079281494,-0.043038044,0.066593274,-0.080980375,0.088018805,-0.030513445,0.024670934,0.06364316,0.030641198,-0.02995603,0.10187015,-0.010815984,-0.015497813,-0.02603708,0.06892172,-0.033074945,0.0025615902,0.020900605,0.023691451,0.052428976,0.062341396,-0.017514478,0.0026314228,-0.03653992,-0.084826455,0.03840576,0.044772156,-0.018975819,-0.04590944,-0.09401504,-0.007907355,0.070730686,0.042928707,-0.021785907,0.025294304,0.03435516,-0.10989907,-0.11254665,0.01879335,-0.057059757,0.050005235,-0.017025778,-0.06779013,-0.045908365,-0.050852977,-0.01723329,-0.011982518,0.1281783,0.016594637,-0.024242157,0.082651354,-0.027940467,0.0919771,-0.0257859,0.034598947,0.100045666,0.058465194,-0.07161044,0.0063197096,-0.052430104,0.044375133,0.083201244,0.004650867,0.015213075,0.013372273,-0.0428826,-0.062381163,0.03391645,0.04589555,0.037193652,-0.04293308,-0.0076157725,-0.030247673,-0.012372911,0.046059225,-0.0422264,-0.03188367,-0.041600257,-0.04559732,0.05324882,0.04528059,-0.07072437,0.039576903,0.00883687,-0.015528328,-0.022300266,-0.04429743,0.08420038,0.004619241,-0.15015852,-0.089001894,0.052185584,-0.05748495,0.028763376,0.07625513,0.017603934,-0.027657006,-0.058178533,0.0050091185,4.88697e-33,0.043414276,0.025189498,0.013679868,-0.058012567,0.0624983,-0.017579766,-0.06992207,0.05249501,-0.007936307,-0.058749862,-0.008432149,0.009486062,0.059938237,0.007142916,-0.030249745,0.038490996,-0.032803647,-0.017316645,0.046242166,-0.076726414,-0.034963507,-0.033660363,0.0017076738,0.033351976,0.014706841,-0.010283112,-0.041756622,0.0046152244,0.038681414,0.022318373,-0.0029813389,-0.11255949,-0.08049027,0.0392524,-0.0129828835,0.0031013591,-0.077095635,-0.08501385,-0.030213933,0.03874259,-0.032591138,0.05244619,-0.08034647,-0.037853964,0.026970185,-0.013360479,-0.065541424,0.08833437,0.009083988,0.12877579,0.036074664,-0.034996435,0.061867915,0.05841058,-0.046848595,0.03511436,-0.0243177,0.05088179,0.069594644,-0.017434288,-0.012745232,0.07593561,0.030048788,0.009168262,0.033285808,0.029652646,-0.023294954,-0.025703011,-0.03949098,0.07259956,0.05941059,-0.020305358,0.04269502,-0.014831248,0.017026689,-0.016804818,-0.06819594,-0.03923856,0.03439643,0.03660068,0.0023048567,0.01210467,-7.024693e-05,-0.02185567,-0.052620593,0.025376152,-0.041849755,-0.023020629,0.008192553,0.063324146,0.04532914,-0.072107434,-0.022038512,0.011224354,0.0009914602,-5.64856e-33,0.108950354,-0.09677558,-0.0060640974,-0.062846035,0.005638826,0.015214726,0.01750793,-0.005743271,-0.05296589,-0.035119373,0.08411483,-0.04891778,0.007892543,0.053649794,0.025001965,-0.045751195,-0.00932249,0.103247076,0.04253055,0.04058752,0.06522903,0.01422525,-0.009755264,0.08840741,0.037690505,-0.02830442,-0.057381433,0.017169287,0.0033101032,0.08763647,-0.024205938,0.038397755,-0.02592326,-0.02248195,-0.024534533,0.0930035,-0.056182966,0.027573286,0.04692449,0.073845804,0.00019919327,0.037276447,-0.071756825,-0.014049053,0.08087157,0.03448163,-0.07722898,0.046281856,0.066742286,-0.092477195,0.01821365,0.043599848,-0.06163094,0.026839983,-0.031174727,0.09684601,0.009024389,0.032685824,0.043843172,-0.059416577,-0.12506305,-0.09845999,0.01559451,-0.09102551,0.035340514,0.098631956,0.025640283,0.039468016,-0.023301257,-0.053637926,0.077472866,0.020903245,0.02085832,0.025637269,-0.013766451,-0.011097037,0.014732737,-0.06212105,-0.078370705,-0.0024440312,0.08266141,-0.046411477,0.042496454,-0.0020295973,-0.078500226,-0.10719647,0.009381852,0.03584744,-0.025664447,0.017752673,0.009022899,0.016669009,-0.062369075,0.053211335,0.09001191,-4.6011856e-08,0.027632264,-0.03307048,0.06016365,0.016854145,0.069183424,0.042580735,-0.0018739055,-0.034342717,0.022585716,-0.0739697,0.038541537,0.09922138,0.004042769,0.011149299,0.034331128,-0.013470653,-0.08031654,-0.010941068,-0.015666062,0.066368245,-0.04317465,-0.028860189,-0.046626136,-0.054675806,0.00235132,-0.0721872,-0.016758015,-0.005671111,0.0018708506,-0.05652735,0.05731801,0.075685285,-0.021764947,0.035306074,-0.096916005,-0.07219702,-0.03889602,-0.032340348,-0.085054435,0.021038255,-0.058843948,-0.012771441,-0.07530477,-0.0031410782,0.00088878523,0.040921193,0.016667273,0.0061181677,-0.03682242,0.016772317,-0.0056904578,-0.0045534372,0.004174952,0.00030150666,-0.027051121,-0.010994178,-0.018460918,-0.024668792,-0.10739479,-0.05804828,0.010001892,0.00542224,0.17037866,-0.0072202366 +2.7.7.66,"The delta subunit of malonate decarboxylase serves as an an acyl-carrier protein (ACP) and contains the cofactor 2-(5-triphosphoribosyl)-3-dephospho-CoA. Two reactions are involved in the production of the holo-ACP form of this enzyme. The first reaction is catalysed by EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase. The resulting cofactor is then attached to the ACP subunit via a phosphodiester linkage to a serine residue, thus forming the holo form of the enzyme, in a manner analogous to that of EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase. 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The enzyme also acts on ethyl caproate, indicating that it is an esterase with a preference for lactones (internal cyclic esters). The enzyme is not stereoselective.",384,0.99999994,-0.01431347,-0.0839939,-0.047248606,0.00011956368,0.07742439,0.020930002,-0.063560784,0.06863684,0.06118905,-0.04736405,0.02530431,-0.029384537,-0.074221276,-0.005032556,-0.039364807,0.010027994,-0.0893945,0.049019206,-0.012007962,-0.018357046,0.1137735,-0.01714099,-0.05451027,0.018696122,0.048283786,-0.0065011014,0.104193375,0.022935875,-0.034329776,-0.10681853,0.0037698483,-0.069582626,0.06551195,-0.015524705,0.02510014,0.12268523,-0.0107503645,-0.04292898,0.09220387,-0.050136708,-0.0062674056,-0.021619996,0.049691983,0.011386024,-0.08985652,-0.015317485,-0.044655267,0.059067965,0.027028928,-0.054035455,-0.011599762,-0.008445924,-0.006378353,-0.02669688,-0.01209435,0.09642288,-0.03014518,-0.03635303,-0.005658686,0.04458255,0.0969409,0.008134962,-0.05066103,0.0057209563,-0.07859264,-0.049865276,0.11689922,-0.053354762,0.01725097,0.017294392,-0.045067307,-0.077522494,-0.054776095,0.0031583726,0.0068802168,0.050392978,-0.023861501,-0.052442078,0.09353258,0.0024946744,0.0470983,0.02137958,0.001028979,0.055831622,0.03686099,0.010872967,0.05813935,-0.07171306,0.04736437,0.01363775,-0.0037015483,-0.016233638,-0.088771254,-0.019539211,-0.06538648,0.03653715,0.034540202,0.0052142325,0.038308658,0.014171701,8.4406376e-05,0.039702643,-0.008644829,-0.11319016,-0.094930165,0.0155922575,-0.003627393,0.04875564,0.044937085,-0.019984929,0.004774456,-0.02785574,0.03134517,0.033515368,-0.06392362,0.12784909,0.03719611,-0.043662578,-0.0955558,0.0039486517,-0.061901547,-0.04813136,0.03057084,0.015844904,-0.08013136,-0.024316028,-0.06208672,2.1642488e-33,0.019648654,-0.006979343,-0.04595923,-0.055991463,-0.011794386,-0.012623144,-0.13202061,0.08008263,-0.05950187,-0.030523323,0.03459153,-0.05989722,0.0009621208,-0.014523808,-0.031443812,-0.0016924628,0.03200952,0.027586665,-0.027888965,-0.02217951,-0.03291687,0.04473248,-0.024170922,0.032154273,0.020167757,0.0795642,0.005994986,0.007358864,0.07282653,0.030287761,0.054510444,-0.060307864,-0.046902142,0.11257253,0.024831094,0.069905885,-0.034982387,-0.0030873108,0.08144499,0.0019057996,0.039597698,0.024493264,-0.0027966662,-0.0045182253,0.019745726,-0.019089455,-0.008732639,0.07952663,0.027439639,0.048346784,0.04339746,-0.021321185,0.0029903133,0.03528031,-0.042124595,0.0049174083,-0.07542358,0.053938195,0.01924471,-0.0014157658,0.009766225,0.07100405,-0.021741815,-0.045819655,0.04359103,0.027936462,-0.03496456,-0.068070106,0.01262214,0.045615535,-0.06511135,-0.016821196,-0.0093418285,0.070141114,-0.0112287495,-0.0029099348,-0.023165608,0.01277773,0.08881304,0.00040216095,-0.052869346,0.017432945,0.007928944,-0.073950365,-0.07384733,-0.021629386,-0.043737184,-0.04409264,-0.01720077,0.044473235,0.008645422,-0.074773915,-0.025050076,0.09729622,-0.008456733,-4.2423393e-33,0.08241908,-0.103773534,0.033498242,-0.035135612,-0.004257535,0.008636202,0.032883678,-0.0010521029,-0.018113002,-0.09094525,0.054662444,-0.01185292,0.014342039,0.03097636,0.062585175,-0.019453127,0.061605267,0.028156905,-0.033958655,0.02070963,0.023503257,0.10538675,0.016158633,0.07700512,0.07724906,0.009044808,-0.043415736,0.055571586,-0.013306785,0.065907456,0.008792335,0.022278724,0.0031820873,-0.04177852,-0.07749926,0.06450608,-0.050022442,-0.012179862,0.02809088,0.04375594,0.01357772,0.07051874,-0.037259094,-0.05538415,0.02960456,0.055507958,-0.020690437,0.020306055,0.018514564,-0.07451427,0.07141622,0.037586555,0.008495632,0.024064556,-0.022457693,0.12720688,-0.006177277,-0.015268218,-0.030023156,0.022754677,-0.10826769,-0.040629696,0.029297058,-0.021040812,0.029824767,0.024380302,-0.009038674,0.0032110964,0.003366093,-0.038809154,0.12166721,0.04259233,-0.04953645,0.073068626,-0.1060483,-0.06213293,-0.04832079,-0.09895021,-0.07353065,-0.08371219,0.03696676,-0.000493307,-8.3064595e-05,-0.028600104,-0.02116282,-0.090811886,-0.0027831183,0.039456815,-0.025214087,0.063209616,-0.030484488,-0.05230936,-0.086540826,0.08232216,0.118735544,-3.742943e-08,0.03810377,-0.008103823,0.09392349,-0.031348947,0.030802973,0.0019847737,0.05770011,-0.014476236,0.07603041,-0.06527104,-0.02093706,0.12155022,-0.08057069,-0.022387385,-0.009305794,0.028355764,-0.06906278,0.050897557,-0.04071342,0.023224112,-0.016865142,-0.0462442,-0.06115596,-0.028989583,-0.012711487,-0.074059434,0.042634673,0.053676054,-0.033489265,-0.0061313394,0.03505111,0.0796316,0.04738596,0.03588046,-0.05977355,0.03666153,-0.037510946,-0.04967275,-0.08680792,0.016615242,0.061163887,0.024560407,-0.073113725,-0.019927222,-0.046428878,-0.016139714,0.0051875813,-0.007781251,0.0036530616,0.029627787,-0.0007585272,2.080999e-05,-0.040889554,-0.009281291,-0.10523093,-0.008389611,-0.041250087,0.017321037,-0.048538692,-0.007547384,-0.02265593,0.022487758,0.2082874,-0.06263294 +3.1.7.4,"Now recognized as two enzymes EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141 sclareol synthase",384,1.0,-0.0886057,-0.023092812,-0.041364864,-0.02289994,0.03159281,0.056153037,-0.088487215,0.086425096,0.03556514,-0.039821573,0.005062519,-0.061433587,-0.040672168,0.018509872,-0.04366169,-0.01451812,-0.07519073,-0.010451762,0.012715304,-0.0843226,0.097325765,-0.0010123049,-0.01856074,0.033464734,0.044234022,0.0415281,0.016191967,-0.052004896,-0.010972149,-0.06684669,-0.05183368,-0.01513176,0.047629744,-0.05665282,0.09564215,0.047885653,-0.027982563,-0.10996348,0.011813777,0.02555078,0.06998332,-0.0018830397,-0.027616309,-0.083375156,-0.05596639,-0.025371186,0.032302234,0.0054531265,0.04545211,-0.01884814,-0.087216035,-0.08951749,-0.012400402,0.00877313,0.022315184,-0.0012413624,-0.08347809,-0.0012551894,0.012543391,0.07604116,0.00773031,0.001762254,0.0050118794,-0.026182467,0.06461812,-0.0018658129,0.058766905,-0.052589327,0.020408135,0.011326704,-0.11598738,-0.0143923955,0.016900534,0.05262245,0.013119868,0.051295437,-0.0353641,-0.032403238,0.06555323,-0.0666542,0.031136373,-0.03981975,-0.10880799,-0.03696743,0.014052394,-0.0007227384,0.01230519,0.0326887,0.08033081,-0.032273963,0.046581905,-0.021038216,-0.007189339,-0.014002789,-0.022492701,0.07593552,-0.0238577,0.08085907,0.04243424,-0.04278804,0.06481427,0.095156275,-0.024102287,-0.06296604,0.004598057,0.004530343,0.034894686,0.101371676,-0.010592353,0.01294444,0.035429433,-0.04311729,0.09045681,-0.041253675,-0.026721854,0.121841796,-0.08102277,-0.07755939,0.0038940182,0.020840397,0.058116872,-0.0028533728,0.008785355,0.115609184,0.031304754,0.06931361,-0.12328681,1.46684595e-33,0.088786304,0.09676894,0.05233223,0.024835568,-0.047616683,0.0055657066,-0.054567263,0.07255646,-0.10785629,-0.029186027,-0.015045194,-0.042424224,0.061601326,0.027522612,-0.010168481,-0.06040865,0.050751626,-0.015136595,0.05168597,-0.0076025026,-0.012936055,0.04941506,-0.031156408,0.0778852,0.015002052,0.018599095,-0.07717035,0.014827601,0.076280296,-0.012736448,0.034871057,-0.068223745,-0.10023181,0.017920421,0.037918013,-0.066355824,0.018211337,-0.0757342,-0.011396468,0.045544803,0.0469352,0.027575845,0.028306117,-0.029460516,0.07618906,-0.053704698,-0.09687121,0.07484381,0.080403596,-0.011765995,0.031660087,-0.00957037,0.087929316,-0.034512244,-0.016985761,0.03811101,-0.026236074,-0.029111633,0.044175833,0.06598915,0.0030020666,0.08830644,-0.07949938,-0.011127978,0.01890084,0.044766765,-0.044708844,-0.07050849,-0.010407882,0.07759635,-0.018823562,-0.01381895,-0.0044060107,0.08329267,0.043299016,-0.07120562,-0.070293635,-0.0128433155,-0.0071586147,0.059086695,-0.033736575,-2.4241719e-05,-0.041994974,0.039374232,-0.05561251,-0.06821979,0.026746554,-0.004341986,0.040321413,0.06800257,0.015938517,-0.07467927,-0.04428197,0.046687063,-0.06571925,-2.4387372e-33,0.03829134,0.0015858405,0.01168286,-0.07685455,-0.137768,0.06785662,0.032768235,-0.034175724,0.03661267,-0.009378899,0.13448855,-0.029384281,0.10084863,-0.10734248,-0.022971813,0.033706438,-0.059193816,0.010380958,0.03138345,0.04498001,0.029927248,0.085039385,0.07304373,0.08901505,0.06920841,-0.024050862,0.06569241,0.07477056,-0.03443722,0.06382119,-0.0142889535,-0.03239877,-0.059144326,-0.00994121,-0.07604603,0.0043460764,-0.0172501,-0.034478035,0.0369167,-0.015818609,0.0032868686,0.041261416,0.049633913,0.05810012,0.050632693,0.038085174,-0.007538445,0.054214172,-0.05681833,-0.06361236,0.0013015587,0.016301036,-0.051381316,-0.07110732,0.013647494,-0.039080624,-0.045907333,-0.012645358,-0.024187578,-0.08885432,0.010542924,-0.075070255,0.009196954,-0.012561503,0.057372607,0.06733473,-0.07789185,0.03433998,0.010042933,-0.02821591,0.04504837,-0.03674318,0.006575541,0.028705569,0.008199541,-0.010172248,-0.087763965,0.006557584,0.0065703914,-0.05842752,-0.018480103,0.004128533,0.026136024,-0.06899937,-0.038281664,0.004526161,0.055912867,0.09560873,0.058311205,0.07427408,-0.1033735,-0.0197386,-0.040841457,0.08110794,0.07288924,-2.9597366e-08,0.0694308,0.009418317,0.06450558,-0.049795955,0.029460551,0.020727554,-0.008407739,-0.02551793,0.062256053,0.028266938,-0.08592143,0.019636273,0.03167353,-0.009653663,0.03773329,0.005317243,-0.031582206,0.04703517,-0.008739093,-0.0065701734,0.012303423,-0.0053908224,-0.04706787,0.050215553,0.03161266,-0.06744197,0.044634543,0.028706536,-0.0033767095,-0.022433339,-0.0066463067,-0.00573419,0.038671896,-0.0775585,-0.01430036,-0.015072663,-0.047837257,-0.007407031,-0.06298145,0.03600185,-0.020272398,-0.09747989,-0.085927956,-0.01789635,0.0075756474,0.0025221077,0.054192822,-0.021900432,0.055973932,-0.033250358,0.015075342,-0.045987785,0.032392807,-0.064311825,-0.05431645,-0.038490023,-0.037907146,-0.024875192,-0.030207837,-0.07326602,0.036901746,0.020967595,0.106540866,-0.0074188993 +3.5.4.33,The enzyme is involved in editing of tRNA. The active site contains Zn2+ [1]. ,384,0.99999994,-0.075414404,-0.036735166,-0.105816044,0.006178845,0.037913248,-0.04576563,0.0018496502,0.032145225,-0.01705017,0.0035454659,0.039334856,0.011330092,-0.041165616,0.023667976,-0.08333635,0.032324325,-0.089005455,-0.036226485,0.018336494,-0.031727944,0.043325648,0.14376144,0.02263143,0.010049173,0.008843726,-0.023934832,0.053998027,-0.01933749,0.07281837,-0.029636933,-0.061528757,0.029426787,0.077886924,-0.018128404,-0.024038637,0.032501254,-0.13638088,-0.031686638,0.03577593,-0.0025477272,0.10023089,0.0014249588,-0.015692167,-0.043608785,0.005702393,-0.03830359,0.040439934,-0.009581869,-0.032679763,0.0990611,-0.017599788,-0.08594958,-0.046474323,0.07201807,-0.0058393693,0.08185942,-0.0991299,-0.0055099865,-0.019198498,0.0014328215,0.06377499,0.024554186,-0.022051176,-0.037356764,0.13358425,-0.033715557,0.018395586,-0.02508223,0.032303892,-0.0973218,-0.006449156,-0.013258946,-0.027818669,0.010410265,-0.035115443,0.023328291,0.025608951,-0.072482675,0.001715693,-0.0013740315,0.030594202,-0.053230118,0.06335155,0.09075866,0.041666485,0.07246173,-0.014828309,0.05086837,0.0119351605,0.08912382,0.09143554,0.041935198,0.02914685,-0.021304192,-0.084745325,0.07542055,0.028175205,0.063619025,0.037835617,0.021444965,0.015712058,0.047796655,-0.019827975,-0.08802971,-0.08451345,-0.011027919,0.11736566,0.007777375,-0.017452396,0.03986322,-0.016908972,-0.0034389005,0.0735437,-0.02502604,0.008141941,0.054513294,0.0349953,0.0105471555,0.023735052,0.0010667354,-0.01500467,0.027183827,0.01653168,0.02197507,-0.025093865,0.035822384,-0.11613565,-1.5532876e-33,0.025114026,0.050701477,-0.01463256,0.0041554384,0.0553172,0.005735114,-0.057284765,-0.029462345,-0.060028266,-0.023261068,-0.09411052,-0.0631828,0.016155658,-0.019366458,-0.028126976,-0.04934224,-0.008291467,-0.0035769655,0.03663304,0.006955058,0.036608987,0.03536844,-0.064920716,0.031571947,0.024621006,0.063777365,-0.0049638087,0.02124952,0.036698293,-0.045589555,0.0061177923,-0.06766099,-0.10368464,0.0042018746,0.113877974,-0.013723114,0.022032104,-0.02372537,-0.0918309,-0.02644655,0.004098167,-0.007847032,-0.027299488,-0.0020064784,0.009032632,-0.033816405,-0.07594561,0.06937882,0.014790651,0.0108970655,0.025819441,-0.005567861,0.0052198363,-0.021941599,-0.07422986,0.030683985,0.005214434,0.008187863,0.09538506,0.06000451,0.027188396,0.02765561,-0.037232276,0.08335177,-0.021318972,0.047152407,-0.06422615,-0.07936319,0.04987266,0.051821448,-0.09901631,-0.02316689,0.07948503,0.0028068477,0.037109368,-0.0547133,-0.08713562,-0.05151859,-0.00819463,0.03321634,-0.07438916,-0.08200979,0.010981951,0.013053424,-0.024011774,-0.08627088,-0.007996495,-0.050576515,-0.015978655,0.029202057,0.058651377,-0.020233253,-0.09969389,-0.020390168,0.03576414,6.992668e-34,-0.005577886,-0.07162396,0.007817986,-0.04846716,-0.08633276,0.032455117,0.0041573877,-0.10960285,0.053430896,-0.050312106,0.13203527,0.04576613,-0.034232028,-0.038386427,0.027518569,0.0003000058,-0.030594202,0.012538702,0.0020337254,-0.057736464,0.01886967,0.050867923,0.0027988432,0.04208356,0.013437679,-0.009656085,0.071364075,0.108332485,0.06715923,0.06250708,-0.089556575,-0.005075309,-0.003577122,0.030835254,-0.09030312,0.02410977,0.028736113,-0.04060472,0.0006739696,-0.03905662,0.059287254,-0.038762655,-0.024456084,0.10995393,-0.03214253,0.077132255,-0.032360718,-0.007848734,-0.046301458,-0.039971538,0.13640712,0.019779192,-0.022256954,-0.04745452,0.11043909,0.053510867,0.025330212,-0.017691264,0.033547815,-0.020217946,0.011615597,-0.02505115,-0.032278787,-0.0053523504,0.033729978,-0.003791889,0.014200346,0.08494238,0.012270929,-0.035519943,0.06712839,0.056716863,0.037538923,0.01711574,-0.042850498,-0.070885435,-0.025930848,0.013012782,0.050492667,-0.108632766,-0.015736058,-0.006613125,-0.0044438886,-0.028294824,0.025528843,-0.01619018,-0.013100498,0.1390726,-0.009334593,0.03693624,-0.041780405,0.05020387,-0.02634034,-0.006788961,-0.07512855,-2.0703451e-08,-0.03741546,-0.07294343,0.0098831225,-0.05238376,0.035617463,0.03439145,0.008911562,0.037806574,0.01987637,0.0119835995,-0.024226995,0.06270334,-0.031593632,0.02726723,0.04530466,0.03906426,-0.06874266,0.033828773,-0.042999014,-0.04234659,-0.05228994,0.07777932,-0.13758351,0.023850562,0.03242044,-0.056607466,-0.024081638,0.11107574,0.005719393,-0.05592004,0.03319262,-0.030486176,0.12160621,-0.03600781,-0.05831669,0.05658464,0.033853754,-0.10030877,-0.06570157,0.035963107,-0.027269209,-0.034021363,-0.011189801,-0.044100743,-0.09632553,-0.047034856,0.022636995,0.040777307,0.047787074,-0.04083075,0.030828333,0.009472736,0.019609287,-0.036849003,-0.068341546,0.016364247,0.03641275,-0.054708507,-0.021896882,0.019699719,0.059651338,0.028826285,0.10800657,-0.04255941 +4.2.3.36,"Requires Mg2+ for maximal activity but can use Mn2+, Fe2+ or Co2+ to a lesser extent [2]. Following on from EC 5.5.1.15, terpentedienyl-diphosphate synthase, this enzyme completes the transformation of geranylgeranyl diphosphate (GGDP) into terpentetriene, which is a precursor of the diterpenoid antibiotic terpentecin. Farnesyl diphosphate can also act as a substrate.",384,1.0,-0.06601535,-0.028881831,0.009382594,0.00037479293,0.04951986,-0.04903118,-0.03249063,0.07014847,0.01261503,-0.020811966,0.03152262,0.009207761,0.015514239,0.017458644,0.010017635,-0.05046942,0.008330494,0.026239598,0.077653855,0.0043224534,0.029957633,0.035423886,-0.028203458,-0.07227556,0.046804342,0.04322857,0.08478928,-0.029294135,0.056924738,-0.0292289,-0.0761575,0.036998622,0.0067018825,-0.08604103,-0.0274098,0.13070484,-0.06887398,0.00026029476,0.033576623,-0.0040165465,0.042225618,-0.049053695,0.1060916,-0.041332558,-0.02508156,-0.09327138,0.03684928,-0.0330995,-0.011852712,0.012479031,-0.040310893,-0.02924898,-0.036395382,0.0019039302,0.03921271,-0.06918408,-0.04099439,-0.027581315,-0.059946056,0.006807894,-0.010732511,0.023532562,-0.025632195,-0.06309499,0.02933223,0.011909022,0.037031274,-0.023434341,0.06989564,-0.03621976,-0.11106181,-0.0048622666,-0.010740259,-0.011846293,-0.06935649,0.026421564,0.047126226,0.038359553,0.07756174,-0.054455884,0.05514984,0.030339746,0.04379431,0.06506858,0.050312318,0.0071474235,-0.0014020185,0.06629521,0.03057144,0.054146204,0.07923822,0.08485001,-0.054463703,-0.014856221,-0.10574478,0.056529555,-0.09611756,0.0009455541,-0.0700149,-0.024354393,0.033495527,0.05448238,-0.06835445,-0.02935657,-0.014317022,-0.024275953,-0.011989454,0.010697512,-0.017437056,-0.036554903,0.039129596,0.026071578,0.020532727,0.009772264,-0.067725286,0.017978927,0.019650288,-0.116188996,-0.037100744,-0.0018001554,0.034358244,0.024514647,-0.0008286137,0.0792627,-0.046508145,0.011054322,0.007967786,5.537564e-33,0.042095374,0.077531874,0.030962978,-0.011838683,-0.067564696,0.046559513,-0.06750147,0.041390613,-0.023737015,-0.034015536,-0.040609445,-0.06546374,0.026382452,0.071971335,-0.00047338143,-0.07998845,0.0020791073,0.07347149,0.15209667,-0.062493563,-0.0036642381,0.040193226,-0.011540982,-0.037212588,0.044652205,0.14513683,0.008748165,-0.02875121,0.08617721,-0.02746056,0.019970482,-0.1498264,-0.03122907,0.0018743667,0.030475028,-0.05253131,-0.09683594,-0.05749609,-0.011794218,-0.0068809083,-0.017978922,0.02946,-0.042557962,0.029490696,0.075176775,-0.038690634,-0.022099257,0.052906614,-0.02188116,0.04239423,0.058780767,0.0005569495,-0.0076729027,-0.009285925,-0.09696778,0.030031456,-0.00036184452,0.025852866,0.038398545,0.03990201,0.026574556,0.047784396,-0.037807763,0.018231645,0.04487428,0.05880347,-0.08390442,-0.07085011,0.0070032766,0.1338026,0.006806882,-0.06402449,0.08667509,0.08582804,-0.0060834526,0.000272983,-0.05826111,-0.009687466,0.07103102,0.013254072,-0.009527133,-0.020026693,-0.013769092,-0.064579934,-0.09055724,-0.005063044,0.0035295663,-0.04761527,0.03750403,0.03371602,0.0031900445,-0.04141298,-0.065294445,0.02502836,-0.007726608,-5.825443e-33,0.07884421,-0.06203863,0.024372827,-0.11605775,-0.0690314,-0.00020911166,0.012772398,-0.07934595,0.031144641,0.02981497,0.067673296,-0.010240472,0.061566766,-0.058909226,-0.05820931,-0.036997396,-0.037691,0.05099832,-0.016294405,-0.048340473,0.010921513,0.07671349,0.06345974,0.09876547,0.006070305,0.01239807,0.05232635,0.017535036,-0.010404204,0.12560982,-0.0036936207,0.028280953,-0.044715706,-0.038637247,-0.056832723,0.07731812,-0.017328087,0.027758427,0.0058979774,0.013709885,-0.023659715,-0.005222713,0.04511625,0.065685995,0.0052787606,0.031981513,-0.075156234,0.011395039,0.029374199,-0.0907414,0.037279595,0.053019673,-0.026016612,-0.056938604,0.028652605,-0.035024613,-0.0030650566,-0.080245785,0.05675718,-0.10881696,-0.03504355,-0.09252867,0.03099032,-0.106169574,0.05311556,0.08633069,-0.0037899367,0.07217215,0.048663843,0.036073104,0.029712677,0.07374372,0.085432254,-0.025710968,-0.032864954,0.059393737,0.07572855,-0.0430984,0.015254868,-0.06601574,0.035379436,-0.006754748,-0.0463932,-0.04590893,-0.07178178,-0.08113183,0.027522419,0.094593704,0.013994627,0.04069688,-0.0924296,0.0022760343,-0.059066392,0.05810528,0.03136212,-4.4198085e-08,-0.025954349,-0.04635995,0.044695716,-0.0029012314,-0.055500038,0.06754878,-0.017675193,-0.0455472,0.04562399,0.024947993,-0.034468323,0.039849367,0.008224726,0.007930776,0.053044815,0.0004868794,-0.031507526,0.029136494,-0.051839374,-0.08821288,0.005389725,-0.027728647,-0.102120094,0.056744035,0.06905053,-0.07222633,-0.017125793,-0.020354973,-0.009449877,-0.038141605,0.048280887,0.01655953,-0.02403506,0.06310916,-0.0063631255,0.046306968,-0.06854161,0.0010986063,-0.04269982,0.038642038,-0.08107602,-0.007858111,-0.08863115,0.023941476,-0.09378389,-0.018174494,0.030787434,0.021159364,-0.021570716,0.025231363,0.041400585,-0.04827796,0.0033955136,-0.04010383,-0.027733412,0.018510988,-0.012490756,-0.037194464,-0.035660006,-0.07365608,-0.007667495,-0.020830844,0.14634715,0.013256887 +4.2.99.20,"This enzyme is involved in the biosynthesis of vitamin K2 (menaquinone). In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase, were carried out by a single enzyme but this has since been disproved [2].",384,1.0,-0.04090272,0.0036359201,-0.12565495,-0.019069256,-0.0008513283,0.013328089,-0.037386365,-0.0113395965,-0.01914374,0.038290802,0.0071467822,-0.05300579,-0.008796311,0.029457469,-0.06956388,0.008541335,-0.045488276,0.011845666,-0.0042807725,-0.00045743646,0.059491493,0.022927556,-0.04991549,-0.07298188,0.02996143,0.0072741825,0.021218475,-0.016787989,-0.04289667,-0.022044096,0.032874025,-0.0714657,0.042337462,-0.06747982,0.022911938,0.091198884,-0.061220467,-0.054290775,-0.04022243,0.028578304,0.013462135,-0.012255784,-0.07694481,0.020602424,0.045877043,-0.007573087,-0.0025464538,-0.006714841,0.08663561,-0.023837797,-0.060135614,-0.068272725,-0.003514398,-0.0012440627,0.01123068,-0.009081275,-0.13075446,-0.024346244,0.014341717,0.011138987,0.030175673,-0.018451808,0.027620737,0.0117736515,0.026060445,-0.06778606,-0.03209163,-0.04572269,0.015390942,-0.010671695,-0.03099056,-0.11258162,-0.030646157,0.016839884,-0.03328076,0.046569925,-0.056701932,-0.07948719,0.03161327,-0.043857504,0.03753779,-0.06672979,-0.056678206,0.09170455,0.01708983,0.02059454,0.019565316,0.019666657,-0.019176155,0.098328136,0.032416373,-0.031744484,0.10570401,-0.0331211,-0.04122916,0.051305965,-0.012317921,0.15132341,-0.03932953,-0.05219654,0.011832924,0.041425265,-0.018414764,-0.104274765,-0.036722135,-0.031671364,0.052816965,0.07274569,0.03555872,0.03779376,-0.076975755,0.028310979,-0.050775662,-0.024786603,0.053353556,0.12181523,0.07340299,-0.038349323,-0.08684372,0.019324554,-0.013309088,-0.011497942,0.049628943,0.009968358,0.012941268,0.007837984,-0.017585127,8.934433e-34,-0.017095579,0.044339836,0.053323064,0.033947084,-0.02506025,-0.044938814,-0.10462973,-0.00097629044,0.04132421,-0.098917976,-0.07720098,-0.03901872,0.013572084,-0.009584387,-0.065146804,-0.013923026,-0.0047387243,-0.0521416,0.08884845,0.017830085,0.027130878,-0.012991782,-0.0146131655,0.009577769,-0.023013975,0.021354543,0.03329172,0.023353405,0.030387267,0.00065184897,0.0088543445,-0.06883354,-0.076969706,0.024296729,0.0118237045,-0.035757117,-0.03494878,0.022523416,-0.03450143,0.11014869,-0.022272728,-0.0028297666,-0.043297086,0.014953667,0.077684365,-0.0033694857,-0.045233108,0.12920515,0.08312995,-0.023269432,0.017011825,-0.0038490607,0.09218253,-0.008382971,0.0005455068,0.072936185,0.053348348,0.012980053,-0.0022530847,0.025723515,-0.010375906,0.069821864,0.0032679325,0.05372719,-0.03157101,-0.006345954,-0.08301617,-0.035111997,-0.045269318,0.043567237,-0.014404855,0.01879802,0.06889687,0.018977016,0.083035655,-0.0032609524,-0.0997875,0.03352275,0.0067419684,-0.014740266,0.009691716,-0.058543295,0.013310593,0.03424167,-0.028832853,-0.045045484,-0.030069418,-0.043825373,-0.0026787026,0.048456088,0.051370267,-0.079133354,-0.06948242,0.02772216,0.04143815,-3.265742e-33,0.10814185,-0.047855392,0.054102134,-0.062252656,0.010179987,0.15195356,0.008423725,0.029003367,0.025031295,0.045533724,0.08050151,-0.00047756004,0.10854748,-0.03922747,0.0039397967,-0.044438362,0.0018383259,0.067428485,-0.03303696,-0.09028784,0.0032538308,0.018986145,0.04733628,0.004428553,0.026935004,0.06777591,0.016770365,0.045594208,0.026301822,0.091877714,0.023922695,-0.008502687,-0.0654911,-0.011798299,0.024396969,0.03767301,-0.04526812,0.03407351,0.008118871,0.029627208,-0.061705235,0.040252842,0.020679131,0.016028501,0.084628575,0.053212937,0.0074028657,-0.010001618,-0.015749922,-0.120982386,0.048016477,0.06562946,-0.12812933,0.035647094,0.06541247,0.09044466,0.0066060415,0.008005795,0.06603013,-0.060214553,-0.06271126,-0.095898196,0.025977738,-0.043705057,-0.052166548,0.017616365,0.021073485,0.08687046,-0.002565261,-0.016357731,0.05694171,-0.08451892,0.028246632,0.013971995,-0.072395004,-0.0051596244,0.00714726,-0.06301,0.039737917,-0.07542569,-0.023583455,-0.01593512,-0.016568853,-0.018785542,-0.01511423,-0.13104396,0.06577338,0.0472327,-0.035124693,0.031945452,-0.046897307,0.018552179,-0.13915014,0.06365434,0.065806046,-4.572765e-08,0.037082646,-0.05446098,0.06482848,-0.026899299,0.039977543,0.021798456,-0.09541806,0.045736436,0.1307639,-0.00061290216,0.015498209,0.052431695,0.044413358,0.060070492,0.007476123,0.035078403,-0.005108736,0.033008553,0.018451467,-0.051438008,-0.05166103,-0.045776077,-0.10231371,-0.008805736,-0.026394533,-0.084801435,-0.012127448,0.006058805,0.019289073,-0.07641371,-0.055957172,0.027180973,0.014556606,-0.0143622905,-0.0748327,0.043655876,-0.074116305,-0.017944213,0.04610418,0.0022290403,-0.0435543,-0.07449613,-0.019214272,0.07204998,-0.005992643,0.025174899,0.039791614,0.05837598,-0.051012147,-0.029663732,-0.0008065627,-0.020029485,0.0067199063,-0.08534991,-0.06332531,0.06328693,-0.07646969,-0.084519856,0.017277211,-0.08251487,-0.031943683,0.04378483,0.094371274,-0.0030972562 +5.5.1.15,"Requires Mg2+. Contains a DXDD motif, which is a characteristic of diterpene cylases whose reactions are initiated by protonation at the 14,15-double bond of geranylgeranyl diphosphate (GGDP) [2]. The triggering proton is lost at the end of the cyclization reaction [3]. The product of the reaction, terpentedienyl diphosphate, is the substrate for EC 4.2.3.36, terpentetriene synthase and is a precursor of the diterpenoid antibiotic terpentecin.",384,0.99999994,-0.07651421,-0.029387077,0.044999346,-0.022081265,0.012028178,-0.06147458,0.025632227,0.062359795,0.025934596,-0.015487932,0.052569885,0.0011614814,0.07471647,-0.0010523488,-0.013982758,-0.038068697,0.0019781054,0.032802265,0.059240703,-0.02446909,0.020646572,0.043547183,0.019409213,-0.038439326,0.020537147,0.06854241,0.11352857,-0.019122528,0.04918061,0.0020527572,-0.007608499,0.007986144,-0.0032276604,-0.10695024,0.011480463,0.09203359,-0.07156183,0.012125243,0.014773992,-0.0319805,0.080705896,-0.012582383,0.12005865,-0.045891043,-0.008105448,-0.06796508,0.009262506,-0.0404796,-0.003208661,0.012248046,0.022513937,-0.023053564,-0.014975452,-0.0127633745,0.10873771,-0.057116173,-0.031542532,-0.0030493443,-0.072937004,-0.003496845,-0.00943461,0.02715188,-0.041546743,-0.03603319,-0.007922995,0.031476818,0.037606463,-0.026899517,0.06912789,-0.05736529,-0.08492463,-0.01820751,-0.034611985,-0.011966302,-0.047347378,0.058719736,0.031700455,-0.026370259,0.029624164,-0.062493104,0.1097474,0.008646818,0.09187295,0.086020924,0.027280206,-0.0277041,0.043722115,-0.007160795,-0.0011681037,0.08084003,0.10185334,0.09970453,-0.055695537,0.03521802,-0.106784865,0.057080276,-0.05202045,0.017980007,-0.064895526,0.007987113,0.014553973,0.06224204,-0.094890565,-0.017871724,-0.058109596,0.0024296918,-0.03317219,-0.024817597,-0.015559667,-0.044034638,0.06819193,-0.014060455,0.024606666,0.011692215,-0.049565464,0.03728062,0.02012095,-0.07675297,0.018433183,-0.06053244,0.04848007,0.0072774184,0.016346183,0.043859944,-0.02800113,0.01104352,-0.014062397,3.801304e-33,0.02376681,0.06579533,0.030521302,0.023131987,-0.06860103,0.010562423,-0.07796178,0.059392888,-0.05375576,-0.04257963,-0.05306671,-0.08466848,-0.01845476,0.032569412,-0.031639487,-0.09385007,0.019166691,0.086198516,0.099640526,-0.02261139,-0.008344355,0.059014108,-0.009696098,-0.01963509,0.039093792,0.12697437,-0.013154216,-0.039386276,0.12043467,-0.010799575,-0.008698057,-0.12078938,-0.043939903,0.017410165,-0.00950533,-0.04482909,-0.05619087,-0.037910998,-0.018645965,0.0038156107,-0.067876086,0.0023392332,-0.026640007,-0.014193696,0.044325948,-0.028156355,-0.0029389013,-0.0067523615,0.0018776103,0.038625006,0.09293774,-0.014029321,0.021621399,0.04138597,-0.069501296,0.021104123,-0.029210715,0.014539694,0.053667836,0.043426607,0.04915775,0.07430838,-0.054925095,-0.0057119955,0.032718822,0.06910348,-0.09851327,-0.09404715,-0.031465046,0.13690479,0.0058787605,-0.03846064,0.11521182,0.015414311,0.03474979,0.014691036,-0.07717186,0.04745042,0.05346722,0.012446605,-0.02512364,-0.012157321,-0.0063493736,-0.03915052,-0.07745243,-0.0054275813,-0.0041117272,-0.0149921505,0.020333122,0.05730798,-0.017664693,-0.032072626,-0.052404206,0.07663631,-0.005129366,-4.0518614e-33,0.039201993,-0.023522519,0.047474027,-0.06741342,-0.062558606,0.017311307,0.009657999,-0.050412234,0.049456056,-0.014434757,0.08479982,-0.009489551,0.030767825,-0.03126709,-0.036558803,-0.08473989,-0.013955639,0.08124192,-0.066576414,-0.044962578,0.07923908,0.040307112,0.023999114,0.0818891,0.03199642,-0.01432778,0.10123495,0.016512051,0.02983889,0.12588948,-0.0025348365,0.07086554,-0.062414467,0.03683406,-0.093768,0.09843571,-0.025900373,-0.019475313,-0.040129274,0.049976714,-0.032789752,0.012942561,0.040438466,0.090419084,0.07013091,0.047553737,-0.054784328,0.07543451,0.09416064,-0.051442243,0.025369927,0.011684968,-0.0014844512,-0.026440624,0.013475448,0.009683997,0.014875293,-0.021197341,0.06653453,-0.058479775,-0.023956256,-0.07772799,0.030053256,-0.079133816,0.0031161045,0.03616487,-0.011598702,0.06243674,0.06881892,0.02546333,0.058076527,0.08789518,0.010666143,-0.044570122,-0.0012731703,0.09004636,0.0074732443,-0.08065672,0.031054119,-0.04528795,0.013184158,0.0002989102,-0.015038131,0.009236964,-0.07592934,-0.075150535,0.0050592795,0.07637393,0.007945774,-0.030725634,-0.110825785,0.020014537,-0.081708245,0.0795333,-0.023435026,-4.5681215e-08,-0.05092421,-0.07154379,0.0058173304,-0.01489261,-0.002553169,0.04588854,-0.03121871,-0.05206979,0.04032121,-0.03697864,0.0060727242,0.02172907,-0.056872893,0.014815245,0.019967346,0.02294827,-0.037043486,-0.019552598,-0.046131004,-0.06348006,0.01084405,-0.045164693,-0.10647219,0.001407559,-1.9987556e-05,-0.13330206,0.013786478,0.01557067,-0.047520094,-0.05231384,0.07357502,-0.023387605,-0.05297003,0.040600196,0.0011677917,0.044019192,-0.078269966,0.011765748,0.020115945,-0.015350552,-0.082514636,-0.044507824,-0.040382914,0.019717004,-0.10155155,0.022103757,0.029207295,0.038357906,-0.0633003,0.045245077,0.003702762,-0.04690778,-0.008859994,-0.055364735,-0.021278415,-0.0025640943,0.00067273894,-0.022024753,-0.029234108,-0.11083,-0.010529395,-0.032232814,0.13424796,0.030436259 +5.5.1.16,"Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).",384,0.99999994,-0.057195023,-0.06447091,-0.029280461,0.007340632,0.0776188,-0.020334434,-0.020733012,0.11536674,-0.0133825885,0.038818687,0.0013875198,0.008629193,0.115588784,0.054817926,-0.04233087,0.02488926,0.015524568,0.06129624,-0.030534506,-0.021813894,0.07273261,0.041079007,0.0078749955,-0.04111215,0.023314886,0.029504174,0.053581752,-0.009845498,0.003219603,-0.044774838,-0.007954004,0.019089082,0.057394356,-0.116092026,0.076055,0.06366637,-0.03621796,-0.006303277,0.038161434,-0.04764394,0.008937336,-0.06987446,0.039351154,-0.024676856,0.04114306,-0.09422998,0.012619381,0.023181837,0.076248236,0.06068506,-0.08792262,0.0062528285,-0.04464911,0.038662374,0.050905794,-0.015546945,-0.13980553,-0.0074365065,0.028450228,-0.032416936,-0.015739478,-0.0014989917,0.014603106,0.0050348085,0.020272136,-0.014514512,-0.016000025,-0.09382793,0.039792325,-0.0020299307,-0.021111507,-0.060071766,-0.08286411,0.050540928,-0.030433562,0.033122595,0.050323587,-0.09049822,0.021493599,0.092143305,-0.0058435826,0.025860198,0.14235018,0.039505146,0.043192293,0.026765196,0.102387734,0.04650284,0.019141637,0.094791375,0.01756209,0.042636998,0.014589335,0.004448758,-0.043261655,-0.011575647,-0.044510923,0.047423188,-0.029256865,-0.0021869638,-0.00865293,0.0007369729,-0.028883863,-0.035916433,-0.053513113,-0.008069063,-0.015512476,-0.026366038,0.042738225,-0.013078743,0.058948297,-0.011499177,-0.015346871,-0.00909916,0.018657612,0.068404496,0.05878902,-0.11250513,-0.057425275,-0.029364021,0.05129397,-0.053028088,-0.016018653,0.037776366,-0.098928995,0.048155576,-0.06379836,2.8569472e-33,-0.05413054,-0.034621228,0.05886084,-0.012162987,0.012900398,-0.0022776963,-0.0440171,-0.0018203999,-0.02463803,-0.07162676,-0.08778062,-0.06088643,0.021355994,0.059815336,-0.04823549,-0.035591643,0.028457744,-0.016059585,0.08960949,0.04385305,0.011602149,0.043140583,0.012331152,0.010573076,0.032883275,0.09559004,0.03834656,-0.05459699,0.09817378,0.019040594,0.027975796,-0.09918302,-0.04361405,0.022683531,0.020109156,0.010538972,-0.11141941,-0.04154347,0.0035882555,0.04385594,-0.034604486,0.01466854,-0.08283251,0.028664181,0.06437286,-0.04699717,-0.004937956,0.02284478,-0.042114627,0.013858327,0.09758247,0.03703873,-0.00563918,0.007981861,-0.0099744005,0.04239388,-0.028638389,0.04380544,0.06570038,0.0007459921,-0.011618616,0.03322706,-0.0014387263,0.0699645,0.031266976,-0.017908089,-0.07190362,-0.04006717,-0.012679212,0.0072974428,-0.038279247,0.00048540297,-0.030782295,0.019194644,0.02719991,-0.048205443,-0.027626447,0.0004983299,0.0756081,0.012589516,0.0077803903,-0.019795164,0.0075295796,-0.028822262,-0.07120675,-0.030887878,-0.06423295,-0.07879411,-0.048711788,-0.018263368,0.04109765,-0.030602861,-0.103457615,0.1254277,-0.012455899,-5.1259628e-33,0.061048634,-0.07832061,0.072079666,-0.011158951,-0.097325854,0.038986802,0.0155279385,-0.12757774,0.09798426,0.03070801,0.07461898,-0.009250366,-0.0066942093,-0.02708773,-0.008117298,-0.06704884,0.02913277,0.046583693,-0.09024315,-0.044668384,-0.016129766,0.089482896,0.050013512,-0.060505133,0.003436513,0.028865496,0.0344511,-0.02470845,0.017450884,0.104095966,-0.010252373,0.10836539,-0.030414987,-0.09186939,-0.09338787,0.0024744177,-0.014666043,-0.062365163,0.019484026,-0.0022764301,-0.014800057,0.074664466,0.046637557,0.039810345,0.003302756,0.024933219,0.03072171,0.02426828,0.03907706,-0.080838285,0.044515956,-0.007359392,-0.042244587,-0.020267207,0.041442357,0.011704111,-0.016813425,-0.01026363,0.012732823,-0.08809905,-0.041284177,-0.030952081,0.04223487,-0.027781332,0.05530375,0.1384585,0.027823005,0.05375327,0.0486827,-0.047254656,0.0779437,0.03656966,0.029653778,0.036723856,0.029199522,0.028884288,-0.06759427,0.018230079,0.03754128,-0.023172915,-0.079380214,0.017097564,-0.017639184,-0.06779591,0.0021179176,-0.17503403,0.027718944,0.07880517,-0.04292042,0.02883663,-0.0662665,-0.0033427984,-0.08214718,0.067646585,0.045688964,-3.7595292e-08,-0.03793578,-0.047785733,-0.009318546,-0.07257446,-0.010253469,0.047369536,-0.054758042,-0.03984854,0.09193305,-0.00042585077,0.045264356,0.027075987,8.960333e-05,-0.045628153,0.03900941,0.026787205,0.026707752,-0.07394522,-0.01892465,-0.08637694,-0.038954407,-0.04666738,-0.031211125,0.0533536,-0.03275806,-0.080743454,0.013757185,0.040377486,-0.03312932,-0.04119591,-0.052875668,0.031090043,-0.027253991,-0.08453119,-0.08624792,0.009059116,-0.026943725,-0.04193494,0.04929101,-0.032542,0.004101003,-0.029569218,0.06508937,-0.022062225,-0.07770395,0.027527148,0.005021225,0.054233707,-0.07720382,-0.02947882,0.02649116,-0.042334996,-0.048855804,0.0044305036,-0.03410533,0.054168086,0.064164,-0.10102445,-0.022997223,-0.089081086,-0.030445436,0.0074338685,0.098965466,-0.035022452 +3.1.4.53,"Requires Mg2+ or Mn2+ for activity [2]. This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation [3].",384,1.0,-0.039958794,-0.04895506,-0.009094818,-0.013223909,0.09482131,0.0067747985,0.017629175,0.047545895,-0.011446148,0.056096718,-0.011035287,-0.017008988,-0.011456482,0.10179558,0.019688444,0.071562424,-0.05339887,0.045505144,0.061884005,-0.051748965,0.06785887,-0.039952498,-0.020326154,0.012067541,0.03901967,0.016604673,0.01576044,-0.03947159,-0.022887329,-0.0050714645,-0.11850101,0.036055412,0.03634135,-0.058084108,0.053178336,0.1529645,-0.11793768,-0.067152485,-0.060783308,-0.0025627334,0.059924297,0.009356381,0.01226925,-0.050682966,-0.02216378,-0.019566339,0.017736286,0.02512726,0.027934566,0.018381929,-0.02328293,-0.053086963,-0.018550858,0.00059636275,-0.026022725,0.010011425,-0.13517947,-0.0041754525,-0.0023373826,0.023151651,-0.03163297,-0.0011495216,0.0059505347,-0.0067340946,0.105640516,-0.05413561,0.028611358,-0.04244861,0.039795473,-0.010125181,-0.021265691,-0.07994921,0.012710989,-0.033772867,-0.01360748,-0.007928951,0.055516157,-0.02292402,0.08697435,-0.036827497,-0.020296039,0.03897955,0.09496109,0.04300019,0.015443463,-0.008727144,0.026967155,0.043011714,-0.035386592,0.09473377,-0.0037787529,0.035289824,-0.11020026,0.009962785,-0.026072048,0.04309811,-0.05983418,0.0145971365,-0.007978679,-0.0056065326,0.054259688,0.10606515,-0.0018060186,-0.0469437,-0.006637598,-0.04791715,0.05185505,-0.006040975,-0.0013829512,0.058937002,0.035760008,0.047987055,0.00784645,-0.00405706,0.014352094,0.09220155,-0.066215105,-0.09102824,0.029991785,0.09165447,0.044179346,-0.08442604,-0.0017127788,0.053253908,-0.09496768,0.08746476,-0.03985072,1.0580725e-33,-0.0152213415,-0.014304577,-0.005029827,0.035915352,-0.031726424,0.079713725,-0.08278937,-0.067358114,-0.035998244,-0.061953865,-0.07587103,-0.08101819,0.05417839,0.058472987,-0.02058852,-0.07675609,-0.043218516,0.029641746,0.095726304,-0.07073055,-0.0042435196,0.011816909,-0.05962704,0.009691902,0.07406967,0.07877877,-0.058367625,0.018269986,0.07346187,-0.0013169728,0.04754666,-0.07313167,-0.080370784,0.0032055576,0.08239209,0.03596557,-0.023339564,-0.073054925,-0.02600103,0.041774623,-0.023237107,-0.028175816,-0.035771042,-0.003320156,0.04369374,-0.046376493,-0.059477262,-0.003811345,-0.04405537,0.005512005,0.059423737,0.030205827,0.043639522,-0.045817163,-0.05181891,0.022637798,-0.03128414,-0.04363083,0.005860594,0.007596182,0.017880179,0.036590785,-0.01198714,0.034141283,0.066169426,0.02485052,-0.093325265,-0.071615756,0.011296201,0.04744037,0.0031617605,-0.10172118,0.11305338,0.038164604,-0.03169475,-0.025513025,0.04567585,0.07274616,0.0059033292,0.051894568,0.0051135356,-0.07328908,0.043689854,0.01265256,-0.02845412,-0.04097156,0.026625106,-0.085580185,0.034169182,0.016228767,0.100707546,-0.007842672,-0.02584385,0.029425219,-0.06040609,-3.551014e-33,0.03349011,-0.02408172,0.037479013,-0.10338405,-0.0942132,0.06753682,0.02085785,-0.10372714,0.031254783,-0.012672798,0.044756707,-0.023724213,-0.02090478,-0.06791085,0.0082898075,-0.024355324,-0.014566851,0.08660504,-0.05369443,0.047426745,0.016877873,0.10651869,0.020040233,0.09122383,0.061466716,-0.011199399,-0.06270125,0.054002598,0.05145648,0.037724722,-0.02318755,0.031181855,-0.054725055,-0.029320505,0.0398268,0.00087313965,-0.042045973,0.013101677,-0.012870607,0.038229406,0.034337416,0.0664408,0.06631894,0.0124807,0.026993578,0.06471432,0.019629616,0.051795326,-0.04760141,-0.05378771,-0.037197698,-0.02629417,-0.06129415,-0.047504403,0.024949951,-0.0062288633,-0.030183692,0.006982267,0.026470294,-0.05274102,-0.030832054,-0.042134997,0.04211596,-0.046396617,0.051638056,0.057064343,-0.031081436,0.017351484,-0.01896329,0.06353327,-0.009872003,0.007198072,0.036017198,0.00020197776,-0.079506315,-0.0043463013,-0.0006640688,0.021551456,0.04496692,-0.14562698,0.0013389894,0.025166728,-0.011616992,-0.07167615,0.0045012487,-0.07043367,0.047661293,0.1178097,0.033094205,0.039218917,-0.00574113,-0.099340536,-0.09882343,-0.0056927106,0.004564614,-5.095119e-08,0.040663525,-0.025267765,0.02971826,-0.092953496,0.040636983,0.047671705,0.017969599,-0.08361942,0.1180864,0.015722794,-0.00080702204,0.0063622,0.02492611,-0.057474654,0.02439294,0.0059881243,-0.032093592,0.055355795,-0.018034684,-0.032063413,-0.13949767,-0.010463625,-0.10156952,0.09196023,0.042267263,-0.00987316,0.029825523,0.088536054,0.038503096,-0.021421451,0.011371381,0.061787426,0.02001384,-0.009342707,-0.08802664,0.063252844,0.012122122,0.008698636,-0.08699724,0.008408441,-0.07961419,-0.034800053,0.06304893,-0.006997821,-0.091877535,-0.027812209,0.009883359,0.004597671,-0.028529339,-0.045879964,-0.0023622124,-0.055210385,-0.05747015,-0.03440043,-0.0045018806,-0.023351936,-0.03048109,-0.07507133,-0.02124105,-0.081900075,-0.04599874,0.030681312,0.06561777,-0.05771939 +1.2.1.73,"This reaction is part of a bacterial pathway that can utilize the amino group of taurine as a sole source of nitrogen for growth. At physiological concentrations, NAD+ cannot be replaced by NADP+. The enzyme is specific for sulfoacetaldehyde, as formaldehyde, acetaldehyde, betaine aldehyde, propanal, glyceraldehyde, phosphonoacetaldehyde, glyoxylate, glycolaldehyde and 2-oxobutyrate are not substrates.",384,0.99999994,-0.019275462,-0.017961543,-0.015933426,-0.032480776,0.060648058,0.07548301,-0.022800809,0.026481912,0.03670027,0.013005908,-0.021559535,0.033191524,-0.07553412,0.05505787,-0.0492909,0.053511333,-0.01084344,-0.032960895,0.08746911,-0.0018160831,-0.0022128057,-0.0025620137,0.0013128833,-0.03979441,0.09844144,0.015945816,-0.013323839,0.0043846155,-0.01873916,-0.015014141,-0.004719956,-0.0066363076,-0.015681908,-0.10701379,-0.0028625354,0.0038262233,-0.06009317,0.016318563,0.003947777,-0.0024905275,0.050146323,0.03723563,-0.05290786,-0.018807936,0.013833894,-0.05126106,0.031556804,0.06842564,0.03844516,-0.0055344673,-0.04551276,-0.012766294,-0.03775865,0.033691872,0.07317094,0.06006515,-0.06464058,-0.11244816,-0.005333406,-0.087981164,-0.0031312532,-0.036931045,-0.0381746,-0.054807443,0.07243409,-0.03459717,0.040555112,0.0009846379,0.05493978,-0.019027904,-0.09280368,0.02350026,0.04108372,0.031672742,-0.0074439025,0.019241508,-0.11917889,-0.016879456,0.10835755,-0.034230772,0.016695982,0.021620806,-0.027817488,0.06909843,0.10887068,-0.0006694308,0.02992351,0.007538574,-0.01144118,-0.048047155,-0.014956699,0.022327416,-0.05248677,-0.01073098,-0.06964307,-0.01564913,0.029889427,0.025667472,-0.0018615949,-0.021542938,0.0021360584,0.04795742,-0.0075792447,-0.10092574,-0.096798845,0.030951034,-0.037905585,0.119389914,0.024987485,0.023184575,-0.060946215,-0.01716791,-0.006497508,-0.026238848,0.053111464,0.09754185,0.032723077,-0.078614995,-0.12943521,-0.020137927,0.012235904,0.013657254,0.049254626,0.010745096,-0.03659081,0.062386185,-0.051003072,6.978277e-33,0.09876171,0.05487105,-0.0038815038,0.008062771,0.09785315,0.019509165,-0.09731086,-0.036957767,0.026121078,-0.023274569,-0.006932993,-0.11548288,-0.00046439873,-0.009781747,0.058442377,0.031629402,0.00059263094,0.0003524412,0.062752075,-0.0013791565,-0.024251493,0.08677673,-0.038740642,0.017602941,0.05615195,0.02611217,-0.07905765,0.03952944,-0.074406356,0.0035671692,0.0784025,-0.048194077,-0.14563705,-0.01664555,0.06376961,-0.04414021,-0.09182127,-0.06022172,0.008718469,0.07540965,-0.006411615,0.034736414,0.06040884,0.017738406,0.00064636604,-0.03299238,0.012749039,0.04918943,0.031086762,0.0665551,0.047858175,-0.04811861,0.09678091,-0.11991857,-0.042376004,0.079721734,0.023783153,-0.042272374,0.02491106,0.046129726,-0.0037693395,0.025184372,0.0009141199,0.056451153,-0.04686105,-0.020642145,-0.036304187,-0.05271684,0.054799728,0.075043015,-0.011448623,0.010409736,0.04845227,0.05924869,0.006921274,-0.05855916,-0.06064248,0.051380306,0.016785992,-0.0637386,-0.0035243572,-0.04411529,-0.05381164,-0.045367274,0.009424204,0.016876271,-0.007593636,-0.042244006,0.07688517,0.026877899,0.044708166,-0.024227742,-0.07157153,-0.038166143,-0.0045220046,-6.7118604e-33,0.067469195,-0.084997,-0.013207391,-0.11906303,-0.10201611,0.10854135,-0.025915574,-0.017497657,0.05540884,-0.017688546,0.06833635,0.060851965,0.030312533,0.031745534,0.037559085,-0.008877612,0.010962855,0.07699342,0.008593182,-0.09148381,0.03422217,0.042500176,-0.0062199817,0.017258586,0.08669229,-0.01233481,-0.004770177,0.020094369,0.12415174,0.019225474,-0.0010746229,0.019277697,-0.0630959,-0.07778958,0.08366254,-0.01968395,0.019120447,0.032683566,-0.055516083,-0.012146387,0.051857024,0.013868657,0.0006468075,0.058469277,0.01677751,0.0022197277,-0.03957842,-0.07011735,-0.0073793274,-0.06446257,0.094637856,-0.055652115,-0.022337008,-0.0032969208,0.022396656,0.059771415,0.033403195,-0.013310253,0.06645991,-0.03339308,-0.025939327,-0.019840008,-0.028431533,-0.06431448,0.046359595,0.017973855,-0.051256318,0.0032055085,0.014610848,-0.00882714,0.053901102,0.030804724,0.023565091,0.09641881,-0.045759756,-0.009566644,-0.054958902,0.039070632,0.0025127826,0.007526418,0.0070974883,-0.016157947,0.010051858,-0.06745839,-0.033560287,-0.052740715,0.050101135,0.1237266,-0.032459073,0.0138362115,-0.0011337256,0.0023357945,-0.057509493,0.053273506,-0.010107887,-4.463361e-08,0.004536773,-0.015453793,0.00034790236,-0.025518421,-0.055360552,0.051514063,0.08981941,-0.03944555,0.044768315,-0.019388895,-0.050695278,0.15530582,0.06577189,0.013429684,-0.06396335,0.029169796,-0.04696647,-0.05826111,-0.065994576,-0.07136112,-0.057449337,0.06361743,-0.052435357,0.074997924,0.047251184,-0.07245591,0.027657485,0.02077835,-0.016331704,-0.11379758,0.036735192,0.012263147,-0.032276493,-0.0469476,-0.06914759,0.017835079,0.027675021,-0.054983042,0.05443129,0.0060416027,-0.035667896,-0.053540263,-0.04791361,-0.0034668802,0.058280014,0.012491623,-0.0039703897,-0.06410996,-0.09143677,0.012937474,0.05134485,-0.033311617,0.028457336,-0.08961434,-0.09944859,0.014188951,0.015191034,-0.07176495,-0.0019353394,-0.049847383,-0.0059925974,0.0031660653,0.16190837,-0.0032229584 +1.3.1.81,"NADH cannot replace NADPH as reductant. The Delta8,9-double bond of (+)-cis-isopulegone and the Delta1,2-double bond of (+/-)-piperitone are not substrates. The enzyme from peppermint (Mentha x piperita) converts (+)-pulegone into both (-)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyse the reverse reaction. This enzyme is a member of the medium-chain dehydrogenase/reductase superfamily. ",384,1.0,-0.06397589,-0.043318402,-0.103837006,-0.020081809,-0.015987538,0.096944585,-0.11074687,0.08121797,-0.0091277165,-0.06518194,0.027366962,-0.0043846313,-0.05898219,0.009690105,-0.016504135,-0.045947842,-0.037607986,0.029469732,0.039906837,-0.09781066,0.0034625474,-0.011082114,0.02577209,-0.081494264,0.09897421,0.07131479,-0.06441781,-0.038440038,-0.014098231,-0.103967935,-0.046626255,-0.010149493,0.011051623,-0.055651903,-0.021155162,0.044023864,-0.039185163,0.032417454,0.05388027,0.038611528,0.0033824767,0.024387581,-0.0440697,0.023035264,-0.017064052,-0.062166035,-0.02470492,0.03871672,0.044914335,0.032684714,-0.01795147,0.04298632,0.03179631,0.101300396,0.05796439,-0.00059553713,0.055658355,0.04513679,-0.028600518,-0.05790732,0.03947782,-0.050069887,-0.06487436,-0.015407118,-0.0035400856,-0.052723087,-0.006817791,-0.05708959,0.011763397,-0.01590421,-0.0345048,-0.027380731,-0.022509651,0.030591162,-0.02469872,0.077840015,-0.053642772,-0.016989615,-0.03318892,0.07033175,0.049085356,0.053545512,0.0070982915,0.07053088,0.089468576,0.052709475,-0.0439757,0.007521061,-0.02669335,0.016325522,-0.044644862,-0.020745,-0.042169213,0.00486897,-0.16184574,0.0049938518,-0.020094031,0.0452584,-0.07119763,-0.014379922,0.029766575,0.06381651,-0.08961373,-0.08693218,-0.07635851,0.012309008,-0.048382204,0.07188151,-0.02299695,-0.017103182,0.017133985,-0.012383892,-0.0023927279,-0.040654562,-0.04452675,0.09507939,0.018049914,-0.012770654,-0.13891566,-0.061068173,-0.0016906854,0.03910104,0.015781853,-0.015825927,0.015392132,-0.063025385,-0.08749797,2.0007147e-33,0.07164168,0.072098106,-0.00977648,-0.019804731,0.022885565,0.023627793,-0.0434081,0.084874816,0.046671312,-0.063987285,0.02796822,-0.056686178,-0.036556646,-0.06943825,-0.014134747,0.019743744,0.019099137,-0.069457315,-0.003371066,-0.0390754,-0.0027462034,0.0819392,-0.08416573,0.015158349,0.011277131,0.034682374,0.0424137,0.034530707,-0.004883728,0.011002803,0.0018761925,-0.040076394,-0.044141054,0.049218208,0.024343157,-0.013076793,-0.027765622,-0.045402527,-0.001718736,0.059416484,-0.069406174,0.061338786,-0.0419146,-0.013203698,0.058147535,-0.11378088,-0.01532274,0.0375458,0.0659671,0.06390383,-0.011365862,-0.0028419022,0.14617015,0.021077583,-0.019946137,0.062321704,-0.022988247,0.033754263,0.0038679144,0.115328744,0.078070946,-0.0068082567,-0.0054358286,0.042644635,-0.041525528,0.04929117,-0.12110533,-0.06338529,0.035372116,0.11628689,-0.0071927216,0.02387905,0.010916686,0.06650955,0.05121463,-0.080574654,0.00943656,0.053538542,0.11861104,-0.049340624,-0.030496085,0.011744723,-0.04078605,0.017561495,-0.021650206,-0.013857964,0.035643358,-0.029708277,0.014664017,0.05459378,0.054131392,-0.014839945,-0.001208963,-0.0115051,0.047523107,-2.7086242e-33,0.05151113,-0.0021881708,-0.006766864,-0.104141705,-0.015352306,0.091338664,0.052263808,-0.007541099,-0.03331964,-0.046267036,-0.023816139,0.044399336,-0.004968342,0.0143360095,0.0046815,-0.015625626,-0.02135158,0.046027604,-0.03048206,-0.0013842135,-0.021292726,0.15666513,0.012966438,0.033643313,0.02394222,-0.05747261,0.011401735,0.08633787,0.08084503,0.016165081,0.036956467,-0.008967397,-0.08128769,0.0064175623,-0.00730667,0.08736645,-0.039571647,0.04545661,-0.013667434,0.050884508,-0.011083293,-0.05123203,-0.051794857,0.01152912,0.105309606,0.006616746,-0.12097272,0.0061488743,-0.008489474,-0.103313915,0.06395909,0.019843033,-0.028777914,0.0061116265,0.03982757,-0.017334608,-0.036512423,-0.035741534,0.06190186,-0.007743034,-0.028821345,-0.03421226,-0.027856546,0.02471817,0.055102803,-0.04240009,0.057049565,0.013728645,0.04148472,0.007396226,0.09331216,-0.013466215,0.05328307,0.10051063,-0.015391271,-0.11719169,-0.06763986,0.015167256,-0.013014694,-0.0522355,-0.0039101816,0.0026737358,-0.011169888,-0.06460149,0.046690434,0.018257014,0.0589988,0.05584896,-0.03331289,0.03847625,-0.00041863165,0.059180945,-0.068858,0.065738425,0.081120044,-4.0853962e-08,0.09248675,-0.046684615,0.0059061004,0.021277096,-0.030220944,-0.031344257,0.004004439,-0.08080038,0.0009676959,-0.016778162,-0.013391799,0.10289566,0.10215636,0.059651658,-0.0051564365,0.03187123,0.027842905,0.014211316,-0.023515949,0.03807383,-0.08659833,0.02342611,-0.093014054,-0.008412212,-0.028267618,-0.02208252,-0.0069236946,-0.028257558,0.008977584,-0.048375364,0.06698536,0.013108905,0.056515664,-0.012217218,-0.053367883,-0.028893689,-0.026411295,0.057022516,0.023748623,-0.025265137,-0.020067861,-0.097814225,-0.03726301,0.08624372,-0.009887232,-0.03065086,0.038410943,-0.038279988,-0.026841069,0.02436537,0.04654907,0.020056339,0.03057233,-0.13446994,-0.07078062,0.03465126,0.0018994918,0.01594774,-0.041695736,-0.06162299,0.024327682,-0.038493235,0.10489959,-0.010491983 +1.4.3.21,"A group of enzymes that oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, monoamine oxidase, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. In some mammalian tissues the enzyme also functions as a vascular-adhesion protein (VAP-1).",384,1.0,0.001171501,-0.04224003,-0.0068349624,-0.046530817,0.06732513,0.020665871,0.009574137,0.047331877,-0.02740708,0.04495886,0.0036605683,-0.053789087,-0.08592545,0.116539724,-0.058271024,0.01975551,-0.011792488,-0.08987882,0.010265884,0.046064924,-0.04389025,0.057341438,-0.03626892,-0.023433335,0.009946711,0.06310095,0.02045283,0.020551592,0.00062962977,-0.022059526,-0.020876957,-0.07116505,-0.0010949164,0.046899658,0.038237166,0.057711057,-0.033445965,-0.00057345594,-0.05725952,0.062367965,0.054064255,0.026210023,-0.021447625,-0.037906107,0.07041005,-0.05381215,0.022574147,0.05276655,0.04213378,0.064747065,0.041800667,-0.026299963,0.047406375,0.14017671,0.003843176,0.044748966,-0.10443571,-0.042445567,-0.07318725,-0.020004002,0.010216051,0.031081347,0.0042292736,0.015740298,0.07753283,-0.043002166,0.03550519,-0.0070153154,-0.012715742,-0.027136877,-0.035267394,-0.04301862,-0.052652758,0.05691076,-0.029956527,-0.047929,-0.03170357,-0.019279119,0.07062365,-0.026932847,-0.040687755,0.066950925,0.0017290999,0.102781236,0.043529708,0.08037754,0.0019562696,0.018107116,-0.0077020465,-0.09627988,0.015046852,-0.005048266,0.012276763,-0.045037065,-0.03482507,-0.014105322,0.0031582515,-0.013511144,-0.025293326,0.017940637,0.0059713395,0.034784455,-0.034770146,-0.056130037,-0.04546731,0.02532053,-0.032670308,0.06087619,0.016424181,0.01594441,0.0148729775,-0.0028009731,0.064485386,0.015013546,0.031767074,0.061545245,-0.029012712,0.0019353079,0.0156201925,-0.026411604,0.0023157387,0.021031676,0.04163017,0.0035513744,0.03195295,-0.045086678,-0.047213312,1.314503e-33,0.0703341,-0.051424995,-0.027614921,-0.02580636,-0.0111406725,0.04964126,-0.047174312,0.09001843,-0.006976133,-0.05470899,-0.088151105,-0.017573355,0.08851967,0.07924484,-0.016316785,-0.002055225,-0.055312283,-0.025903543,0.106952585,-0.07218831,-0.028827924,0.06657983,-0.030368028,0.0361401,-0.054844577,-0.03625732,-0.08200681,0.028325135,0.027221002,0.013243733,-0.020937972,0.01084486,0.012310414,0.010495096,-0.07152122,0.024198653,-0.0007965872,-0.030224375,-0.044307813,0.030603977,-0.0072519816,0.050548457,-0.05219775,-0.080726616,0.029200634,-0.10924,-0.08545596,0.08194571,-0.03741904,-0.04398746,0.045360815,-0.009075805,0.06063274,-0.06629291,-0.11694794,0.008944835,-0.043313604,-0.028010644,-0.0049901786,0.037970252,0.0071911053,-0.0035051524,-0.08110939,0.030765556,0.0058559524,0.017300133,-0.0149738705,-0.07651962,0.05971728,0.07870749,-0.10445658,0.027926732,-0.0030129645,-0.053362194,-0.0027648723,-0.08447689,-0.055003442,0.06592446,0.022057246,0.07113564,-0.044293817,-0.09569082,0.0057155187,0.004384196,-0.013215471,-0.087839186,0.0815818,-0.08307047,0.0019388442,-0.05350132,0.053342633,0.0035352013,-0.02486929,-0.025677662,0.04350302,-3.901108e-33,0.04270251,-0.08985778,-0.0216164,0.022116309,0.02536241,0.07351499,0.020753467,-0.0016751523,-0.012029231,-0.06580516,0.07215338,0.021740153,0.01406063,-0.013215881,0.044829745,0.027474135,-0.07211338,0.04136105,0.012162383,0.0066066184,-0.0019267662,0.04932363,-0.010805578,0.034224242,0.07260524,-0.013492631,-0.11549457,-0.06349164,-0.0076189386,0.090736896,-0.039755404,0.061295107,-0.09365731,-0.06032002,0.024526507,0.06849693,-0.07410434,-0.0035398842,-0.009219703,0.03727534,0.0059754923,0.043984756,0.034828108,0.027342796,-0.006504009,0.082558304,-0.11983838,0.009987674,-0.1404736,-0.024986507,-0.0045930753,0.08007519,0.018949805,0.02358756,0.063645065,0.07087058,-0.00039930776,-0.050964057,0.044806313,0.020258183,-0.072504036,-0.01291862,-0.058639772,0.0341971,-0.005196535,-0.030455975,-0.042874295,0.055084854,0.040655017,-0.0072318087,0.037490334,-0.0007648834,0.12468146,-0.00041062248,-0.091484286,-0.032890808,-0.040857006,-0.017993283,-0.0032792771,0.019907601,-0.011945874,0.014413147,0.043184943,-0.008101255,-0.101375304,-0.0459598,-0.027585197,0.12315128,0.007981385,0.052669704,0.0015441193,-0.07255188,-0.074645594,0.06828529,0.03410644,-4.5163475e-08,0.037380476,-0.07965965,0.03855072,-0.00090795977,-0.05717098,0.081693895,0.032992195,0.05541049,0.056030624,0.011171065,0.094374746,0.08496134,-0.05199708,0.010253352,0.025474997,0.06808269,-0.003924837,0.030746689,-0.044104334,-0.041939735,-0.027898278,-0.026057275,-0.028908044,-0.0054398943,0.007890452,-0.057974033,-0.09187421,0.023488786,-0.089884296,-0.03241082,-0.0016059537,0.05793106,0.03435623,-0.036485408,-0.058799345,0.09487252,0.055260185,0.01517646,-0.041845925,-0.013408241,0.01980093,-0.057144474,-0.07969954,-0.043693677,0.059203878,-0.06634401,0.10200936,0.0023224184,-0.008207487,-0.08053335,-0.010488366,0.017215028,0.03998102,-0.05663721,-0.0652964,0.016071195,-0.081957236,-0.084263675,-0.037766196,-0.058476046,0.030783134,0.066473834,0.18970639,0.020430366 +1.4.3.22,"A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.",384,1.0,0.020223247,-0.048719678,-0.022791686,-0.065772645,0.094189465,0.028745329,0.006599622,-0.0013127772,-0.019163031,0.01848438,0.021638775,-0.07764837,-0.034892634,0.054299913,-0.037046682,0.022333497,-0.02528171,-0.06933401,-0.042617366,-0.006083603,-0.040621106,0.0034837823,-0.007566017,0.028302372,-0.043447632,0.084866926,0.04866817,0.016419506,-0.0101378895,-0.034882877,-0.030685758,-0.025115056,0.06752621,0.036307417,0.029319523,0.056015786,-0.01805219,-0.0017706985,0.014950899,0.04708661,0.011556242,0.05175162,0.014021156,-0.05124796,0.049827266,-0.102142125,0.018622689,0.032931,-0.0012985135,0.009076874,0.03750665,-0.052385293,0.01802641,0.14559445,0.067309424,0.0376061,-0.09221962,-0.06491895,-0.05605242,0.0010307325,0.041875105,-0.0021223691,-0.01227555,-0.016214048,0.031872153,0.01110258,0.004828565,-0.043637834,0.017981242,-0.049600817,-0.06001222,-0.08650857,-0.021931449,0.050211214,0.016596578,-0.09273899,0.051957857,-0.02052935,0.0354055,-0.039403208,-0.09112829,0.004396514,0.028333407,0.048215136,0.06591849,0.012236669,-0.02649796,-0.015109194,0.017799446,-0.038562886,0.03102334,-0.024155123,0.05242849,-0.07314208,-0.0022902095,-0.0067159063,0.035542853,-0.012923334,0.0028244986,0.01959724,0.054595165,0.010106849,-0.08723717,-0.08682899,-0.06185186,0.021781811,0.0035654514,0.074225485,-0.0034078895,0.0263509,-0.024130007,-0.017654022,0.05884984,0.0012396544,-0.015563863,0.030989157,0.020062156,-0.009617734,0.028079433,-0.031504523,0.025033431,0.028715407,0.101046145,0.03360147,0.046988986,-0.0086608175,-0.06525126,3.120447e-33,0.089060366,-0.013638311,-0.029603438,-0.03954526,-0.03313868,0.063682444,-0.07795278,0.11779577,0.028435376,-0.0922398,-0.09115627,0.020332308,0.07796368,0.050401393,0.029111871,-0.010322922,-0.04273643,-0.046683237,0.10452323,-0.09312415,-0.04660294,0.08479677,-0.02293674,0.020932524,-0.00989824,-0.0070630573,-0.022002729,-0.0024246087,0.03834924,0.013169707,0.009124895,-0.014882366,-0.00077310763,0.03313082,-0.072921686,0.05572014,-0.028070817,0.031155724,-0.036200576,0.063645,-0.06718356,0.039430954,-0.038579132,-0.07571009,0.035202656,-0.093261495,-0.033111703,0.107916065,-0.010536262,-0.031554103,0.010408329,-0.010788179,0.056041755,-0.06236881,-0.100903116,0.0033283362,-0.027514478,-0.022224521,0.06372366,0.022589967,0.033019762,0.020026172,-0.08283152,0.015238535,0.00027650996,0.018573675,-0.009261567,-0.05514957,0.06515564,0.078127645,-0.09486492,-0.0010064997,0.06273115,0.004426197,0.060273934,-0.08187457,-0.08365444,0.037627596,0.037745584,0.08295176,-0.025813429,-0.06971247,0.01912956,0.026376583,-0.029084874,-0.09109847,0.026647827,-0.048705883,0.004902091,0.009594404,-0.02281369,-0.026481777,-0.035883978,0.00087791664,0.053543415,-4.687657e-33,0.056943536,-0.06483977,-0.07495801,0.021595905,0.018640049,0.006974285,0.0015589235,0.010407506,-0.003508043,-0.05799004,0.08419726,-0.047481485,0.022503624,-0.032255556,0.04804492,0.004950233,-0.08684573,0.067522004,-0.0044204583,0.023468241,0.005057675,0.01189604,-0.061765086,-6.346951e-05,0.074780926,0.017327905,-0.09727167,-0.010408823,0.029393565,0.07727045,-0.07278157,0.04886067,-0.0438638,-0.042511072,-0.015929528,0.0822466,-0.0908077,-0.015107077,-0.06569397,0.04232118,0.020751344,0.049107417,0.06736836,0.038846366,-0.021604916,0.080453545,-0.112948135,0.023446677,-0.11045186,-0.015191485,0.010192067,0.04745548,0.0072168023,-0.009653928,0.08040255,0.031624638,-0.034302767,-0.048098307,0.03916308,0.04191078,-0.056606583,-0.06013356,-0.028952325,0.020709004,-0.021044698,-0.037761208,-0.12522976,0.07989228,0.05855107,0.02560835,0.043065634,-0.059707627,0.08595877,-0.037768338,-0.09399911,-0.08253599,-0.06214794,-0.0050508464,0.021418544,0.00578456,0.008119949,-0.051008083,0.0700593,0.036276132,-0.09136947,-0.025298981,-0.015669813,0.1145475,-0.0019842596,0.065357715,0.023517141,-0.056574702,-0.04389395,0.12265004,0.06647093,-4.493521e-08,0.04847184,-0.08410242,0.06787611,0.015216098,-0.002197972,0.06324673,0.026447898,0.04719036,0.014096206,-0.0012197066,0.09242767,0.06636552,-0.047526702,-0.023747938,-0.008168564,0.051712196,0.00046662797,-0.008746919,-0.0049617267,-0.022272453,-0.038935453,-0.016544098,-0.07233498,-0.0014766646,-0.012625616,-0.010629123,-0.024580225,0.024572235,-0.098629355,-0.019279381,-0.011787024,0.045170568,0.04030608,-0.049670596,-0.07345834,0.07475966,0.024004161,0.024560677,-0.021079617,-0.037321273,-0.0053621414,-0.07389524,-0.13950545,-0.00487742,0.06533463,-0.099444896,0.048607346,0.033388637,0.0025832818,-0.06791074,0.0072014574,-0.015122364,0.08265484,-0.029523687,-0.025346762,0.059087224,-0.034464743,-0.0965804,-0.07899386,-0.05041638,0.073655985,0.029390447,0.14703722,0.01819187 +1.14.13.104,"A heme-thiolate protein (P-450). The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan [1]. This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalysed by EC 1.14.13.47, (S)-limonene 3-monooxygenase [1].",384,0.99999994,-0.07834183,-0.0156533,-0.06539993,0.01401013,0.10072266,0.043586332,-0.04532989,0.15053411,0.007044347,-0.060817044,0.044436615,-0.027358191,-0.04841135,-0.015468067,0.011424107,-0.042144626,-0.04638301,0.0312531,0.0015521402,-0.08559458,0.03236933,0.010617619,0.008119943,-0.010250692,-0.01876743,0.04401605,0.04218113,-0.0015576889,-0.0133666415,-0.045797493,0.013518323,0.0025295485,0.017213037,0.005722074,-0.046073616,0.061346076,-0.021553332,-0.11302767,0.07879349,-0.047061875,0.11435701,-0.022367086,-0.04956083,-0.03450669,-0.025368655,-0.06376859,-0.0037842158,0.009288847,0.00038451666,-0.055072486,-0.0052869064,-0.0013120981,-0.020707866,0.054995246,-0.046087984,-0.0036607927,0.05616847,-0.009018196,-0.010274483,0.024106797,-0.04448307,0.06378109,-0.06757526,0.020865003,-0.007900777,-0.09322623,-0.023736298,-0.021096386,0.0043422403,-0.061003257,-0.014324793,-0.07679653,-0.088708036,-0.031417027,-0.06931479,0.076718055,-0.0030740802,0.021234011,-0.057196394,-0.018513173,0.05800935,0.0774543,0.026123583,0.103167936,0.02046016,-0.014150443,-0.057414584,0.039617117,-0.016655922,0.022884686,-0.0031247851,0.049885917,-0.033073008,0.027165148,-0.12646864,0.07065922,0.08307193,-0.022939822,-0.022190342,0.020738978,0.0034009377,0.08948871,-0.05337191,-0.1191555,-0.055772476,-0.005145633,-0.007106494,0.03951371,0.053820346,-0.06281436,0.034851357,-0.052057344,-0.003419436,-0.03091878,0.0017414286,0.10226367,-0.0052150916,-0.02012025,0.0064070537,-0.03497321,-0.03074234,-0.0103733875,0.009794855,-0.018345157,-0.03471929,-0.009387683,-0.0354587,1.631961e-33,0.033501003,-0.02765434,-0.017948493,0.032360755,-0.05008512,0.01997321,-0.064580135,0.061240997,-0.0031674071,-0.029651579,-0.056250762,-0.097328626,-0.040916607,-0.012761021,-0.067240864,-0.06663867,-0.032324325,0.06467747,0.0828909,-0.008440087,-0.054487452,0.012071841,-0.035677385,-0.02108537,0.03267353,0.09320585,0.0355051,-0.053621575,0.057674825,0.0015410205,-0.076924935,-0.003920954,-0.03087097,-0.03788946,-0.002195615,-0.010756229,-0.013154733,-0.026854321,-0.07288218,0.07359744,-0.0023233292,-0.020444825,-0.01444684,-0.089151636,0.01849306,0.01811829,-0.10746489,0.046094086,0.022367928,0.031239524,0.038125698,-0.02738897,0.14295755,0.05893768,-0.044994522,-0.00040061833,-0.013986293,-0.01866047,0.061361115,0.03402736,0.11939905,0.042031914,-0.052918002,0.038024284,0.034812577,0.08937509,-0.098246254,-0.03652766,0.019212669,0.14716405,-0.054422855,0.017859919,0.05479833,-0.018064836,0.12749179,-0.021921962,-0.008420332,0.10342132,0.10521913,0.029361652,0.0043952684,0.025684182,0.008011688,-0.006802987,-0.0036705423,0.00782703,0.0032316581,-0.0042793923,-0.016499283,0.02966768,0.062762864,-0.06397373,0.011537481,0.020117192,-0.05250921,-1.9365039e-33,0.038269397,-0.047985926,-0.021069642,-0.082187325,-0.03153686,0.0629216,-0.03005838,-0.0056891255,-0.052815463,0.015368793,0.07822069,-0.043291632,0.0014849004,-0.052841537,0.0075243604,0.026159732,-0.005442547,0.04560216,-0.054234676,0.05347466,-0.006522661,0.008015392,0.022521513,0.0714407,0.024382114,-0.0036335173,0.026700297,0.0048870523,0.07035992,0.01763536,0.016220234,0.029716067,-0.058272257,0.00045594762,-0.05388909,0.10578444,0.013404465,0.053617377,0.0018108042,0.063111834,-0.057611007,0.008230436,0.01869739,0.08316426,0.04582383,0.018811354,-0.103667736,-0.0475252,-0.014140105,0.015978903,0.055762887,0.017787276,-0.029792046,0.023803672,-0.027466323,-0.017090736,0.02421127,-0.01748352,0.014672024,-0.10872337,-0.062801056,-0.046611536,-0.02993156,0.06083952,0.022462476,0.0039972677,-0.06497422,0.038598083,0.05160499,0.00077419885,0.0754254,0.022759749,0.10151017,0.036756676,0.041237496,0.010557118,0.067714915,-0.04048815,0.03440336,-0.0018010453,-0.022881543,1.3560773e-05,-0.053823274,-0.093801275,-0.06054105,-0.112159625,-0.0019242765,0.0673265,0.0374059,3.88793e-05,-0.023290163,0.06417905,-0.060249943,0.096934214,0.13507545,-4.2089322e-08,-0.029342998,-0.12933125,-0.022830565,0.10175114,-0.027606599,0.064225376,0.017975725,-0.030124769,0.037231755,-0.014983726,0.0024391948,0.05121317,-0.001649626,0.0050713187,0.007571362,0.0254886,0.029141923,0.034802992,0.03463904,0.036261287,-0.04723701,-0.017157445,-0.0022377106,-0.01807739,0.03102036,-0.12877676,-0.054514453,0.0040711868,0.026810223,-0.038386095,0.040049016,0.073741004,-0.04898509,0.029606659,0.054285165,-0.0128289,-0.039918587,-0.01832232,-0.022743579,-0.014716388,-0.043950956,-0.037990544,-0.09949992,-0.012411441,-0.004951519,-0.0019527904,0.006708842,0.08000665,-0.012593977,0.0052773505,0.00023707384,0.00061319716,0.041468844,-0.097003646,-0.08323273,-0.0043422426,0.043304082,0.0060021356,-0.06672809,-0.10994122,0.009203067,0.025871426,0.17615992,0.036955044 +1.14.19.4,"The enzyme, characterized from the protist Euglena gracilis [1] and the microalga Rebecca salina [2], introduces a cis double bond at the 8-position in 20-carbon fatty acids that are incorporated into a glycerolipid and have an existing Delta11 desaturation. The enzyme is a front-end desaturase, introducing the new double bond between the pre-existing double bond and the carboxyl-end of the fatty acid. It contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome. Involved in alternative pathways for the biosynthesis of the polyunsaturated fatty acids arachidonate and icosapentaenoate.",384,1.0,-0.09473334,-0.032568514,-0.112423964,0.0012579182,-0.060642786,0.021115528,-0.06668786,0.045809347,0.0073091015,-0.03860651,0.00936785,-0.060630657,-0.13105142,-0.044796534,0.044187274,-0.03428694,-0.0312048,0.003775563,-0.040417533,-0.018545803,0.1260486,-0.05966261,-0.06559166,-0.0074145524,0.012750451,0.016238555,0.06535131,-0.07681198,-0.023643952,-0.066141345,0.03262008,-0.10178876,0.023288209,-0.0085559515,0.03363315,0.05791432,-0.059587583,-0.044725228,0.036181577,-0.017463632,0.112371854,0.018506423,-0.0108615905,-0.049357794,-0.041958135,-0.09009628,-0.022816913,0.021737687,-0.022426173,-0.051181022,-0.022934541,-0.069416426,-0.0706018,-0.0631522,0.025266703,0.003772298,0.0036787924,-0.023373663,-0.058847453,0.046799626,0.09535831,-0.0061864853,0.02187099,-0.025421087,-0.050932743,-0.10267859,0.017342769,-0.085116476,0.044616185,-0.02765332,-0.06698997,-0.049417727,-0.040157102,0.0456715,-0.02556006,0.07104615,-0.025021497,-0.010588279,0.027491974,-0.0475149,0.053292528,-0.010952002,0.031025002,0.092862494,0.057516307,0.0069189915,0.019735523,0.028057592,0.016443476,0.053732313,0.097767,0.003445339,-0.009252284,0.052821785,-0.091983534,0.014163465,0.041605923,0.000803658,-0.04210398,0.0019906326,0.056511465,0.058935314,-0.019190198,-0.12590566,-0.04859902,-0.0093446225,-0.023946028,0.0405277,0.010010656,-0.0038501509,-0.018873697,0.0033681167,0.024011081,0.047152493,-0.027758377,0.049730983,0.012616455,-0.06582453,0.055548314,-0.031135483,-0.046537027,-0.040518202,0.067363456,-0.0033751365,0.0043803053,0.020737467,-0.07423792,1.4646656e-33,0.04254835,0.00024255161,0.01565099,-0.019644383,0.005893683,-0.04048803,-0.10310384,-0.007070908,-0.067519486,-0.034004003,-0.006101195,-0.0125173265,0.011001597,0.06477884,-0.038302634,0.032243554,0.036587287,0.042882543,0.12238523,-0.0051736855,0.020507198,0.06400566,-0.016615499,-0.07160962,0.022980226,0.080001414,-0.04614886,0.009333008,0.03888766,0.027691074,-0.034569535,-0.14149596,-0.083971605,0.092547774,0.11271698,0.03283168,0.05257383,-0.025468405,-0.021828372,0.057874754,0.06224179,-0.04274051,0.0036512758,-0.049688395,0.060009506,0.0070373164,-0.04886416,0.045770247,0.048005465,0.006350126,0.03066375,0.0106228525,0.0877936,0.056718368,-0.11458511,0.041877672,0.0051127886,-0.010647547,0.00124541,-0.0033737214,0.016883492,0.050060906,-0.059867483,0.01183386,0.07401601,0.038390484,-0.11027633,-0.010010644,-0.0446371,0.09052404,-0.007137069,-0.078995965,0.12732485,0.016117556,-0.009632694,0.019198356,-0.0673413,0.06664766,-0.047491353,0.061528187,0.04094444,0.056743164,-0.0017589503,-0.047037747,-0.07084671,0.052833304,-0.010399396,-0.009587408,0.062319603,0.055101957,-0.0012241054,-0.046180442,-0.028639901,0.023892794,-0.012747823,-2.7827474e-33,0.107296504,-0.09029447,0.02979351,-0.04982541,0.006474051,0.043461964,0.016973687,-0.050808944,0.06686587,-0.029296987,0.087452166,-0.038114585,0.06081036,-0.017520152,-0.019242775,0.0020977124,-0.006599948,0.102480955,-0.026797995,-0.08636525,0.048157655,0.060923308,-0.0018765472,0.10227959,0.037532933,-0.023191908,0.06186269,0.05205399,-0.011322725,-0.0031119043,0.027889786,-0.0145636415,-0.05560675,-0.09418896,-0.10531593,0.0021534748,-0.07345671,0.005553468,-0.0052293832,0.04239193,-0.045964345,0.0033421926,0.03125973,0.051698424,0.13365617,0.033347823,-0.066462114,-0.004510019,-0.0012701683,-0.018114215,0.030966721,-0.021252282,0.010401342,0.05265269,0.052259043,0.055880155,0.030283725,0.047179498,0.02792718,0.001820814,-0.05345864,-0.06765009,-0.010183032,-0.039694183,0.005323426,0.041144695,-0.032019198,-0.03151129,0.010174193,0.028257156,0.06488317,0.071590796,-0.08378524,0.05441727,-0.030706435,0.036429793,-0.024659289,-0.081725046,-0.0019515078,-0.039062873,-0.025375111,-0.017356317,0.009497385,-0.06198325,-0.00013403807,-0.019277912,-0.0148500195,0.085727476,0.0012199699,0.05073232,-0.055267803,-0.031142687,-0.0630767,0.06647716,0.024835808,-4.341884e-08,0.003027043,0.008168987,-0.04038307,0.012349612,-0.07211915,-0.03029075,-0.007637434,-0.071093954,0.08409681,-0.109134175,-0.022812132,0.05863839,0.007833343,0.07722173,-0.011251825,0.050475463,0.042278104,-0.010189525,0.0074899322,-0.032110866,-0.043202005,-0.028587561,-0.056645334,0.012250579,0.017263575,-0.068922736,0.037560396,0.06290427,0.018102903,0.07163516,-0.052088674,0.01659176,0.059745982,0.01088196,0.07725983,0.015208231,-0.006785692,-0.0266071,-0.009374912,0.0641071,0.07689356,-0.048612468,-0.047356743,0.034565814,-0.018221285,0.043836918,0.0019506406,0.04990253,-0.014822965,0.012316729,0.0039042074,0.025885878,-0.031462528,-0.040917136,-0.10547289,0.04343554,-0.050081227,-0.007465527,-0.075738266,0.03139093,0.06067599,0.0029969485,0.15510525,-0.025562253 +2.4.1.245,"Requires Mg2+ for maximal activity [1]. The enzyme-catalysed reaction is reversible [1]. In the reverse direction to that shown above, the enzyme is specific for alpha,alpha-trehalose as substrate, as it cannot use alpha- or beta-paranitrophenyl glucosides, maltose, sucrose, lactose or cellobiose [1]. While the enzymes from the thermophilic bacterium Rubrobacter xylanophilus and the hyperthermophilic archaeon Pyrococcus horikoshii can use ADP-, UDP- and GDP-alpha-D-glucose to the same extent [2,3], that from the hyperthermophilic archaeon Thermococcus litoralis has a marked preference for ADP-alpha-D-glucose [1] and that from the hyperthermophilic archaeon Thermoproteus tenax has a marked preference for UDP-alpha-D-glucose [4]. 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+3.1.26.12,"RNase E is a bacterial ribonuclease that plays a role in the processing of ribosomal RNA (9S to 5S rRNA), the chemical degradation of bulk cellular RNA, the decay of specific regulatory, messenger and structural RNAs and the control of plasmid DNA replication [1]. The enzyme binds to monophosphorylated 5' ends of substrates but exhibits sequential cleavages in the 3' to 5' direction [1]. 2'-O-Methyl nucleotide substitutions at RNase E binding sites do not prevent binding but do prevent cleavage of non-modified target sequences 5' to that locus [1]. In Escherichia coli, the enzyme is found in the RNA degradosome. The C-terminal half of the protein contains binding sites for the three other major degradosomal components, the DEAD-box RNA helicase Rh1B, enolase (EC 4.1.1.11) and polynucleotide phosphorylase (EC 2.7.7.8).",384,1.0,0.017406369,-0.036888387,-0.029586038,-0.046534497,0.036899675,0.0413566,-0.076403245,0.058741055,0.028345196,0.0580516,-0.040045906,0.031345338,-0.022687469,0.090718105,0.007439764,0.013752445,-0.10263063,-0.008719044,-0.06655109,-0.055800237,0.10241371,0.08139371,-0.024963629,-0.03989468,-0.029944746,-0.0069380365,0.08097724,-0.026711475,-0.048299447,-0.10631592,0.0077642794,-0.09989975,0.071763396,0.0096667595,0.006905559,0.06231711,0.05665784,-0.13465397,0.09045832,-0.000531811,-0.0023659398,0.07212328,-0.047257412,-0.01935005,-0.02525661,0.0010443822,0.055513963,0.06496445,0.029705388,-0.009193328,0.044740677,-0.07106881,-0.027139956,-0.046354797,0.041574012,0.07020451,0.06860706,-0.053016163,0.028963726,-0.046229236,0.061619233,-0.07294839,0.028735677,0.02889415,0.0358857,-0.07462637,0.12115154,-0.028624736,-0.033530314,0.029536083,-0.05373116,-0.05852821,-0.0841426,0.10601806,0.017063301,0.03287665,0.04789815,-0.05246082,-0.009442486,0.0035773516,-0.051995665,-0.043085154,0.07291223,0.0049163788,-0.026999455,0.087484404,0.017798953,0.023345424,0.0888941,0.033005185,-0.00068212446,-0.052464593,0.052080676,-0.045497715,0.033068698,0.0067128367,-0.02607149,0.04728798,-0.03925925,-0.08338751,0.02035801,0.08975738,-0.06550724,0.02281536,0.0030249509,0.040194687,0.059650235,0.06106073,-0.06752722,0.021816624,-0.011405849,0.0031366684,0.0171387,-0.034416847,-0.014344104,0.024949247,0.06051744,0.001823166,-0.039816443,0.032397754,0.025243273,-0.029476332,0.010212792,0.05759426,-0.09202269,0.015259422,-0.10241928,3.766662e-33,-0.024772672,-0.045352723,-0.014530399,-0.009010964,0.057160217,0.04387464,-0.062951736,0.03651931,-0.0844514,-0.048349887,-0.053463582,-0.056264248,0.06632872,0.0055101416,-0.02626166,-0.03573753,-0.028608894,0.03957854,-0.11438536,0.029927194,-0.022645963,0.0045691505,0.039653197,8.694166e-05,0.006774792,0.020018013,0.00084882526,0.014040906,0.0731875,-0.052390404,-0.03497842,-0.05810728,-0.09167919,0.05877332,0.05639567,-0.03624991,0.022936746,0.047680773,0.0568859,0.07581976,0.043671567,-0.0022500642,-0.046453845,-0.002414965,0.06961114,-0.10563332,0.03465502,0.034449298,-0.06619288,-0.011012845,0.07161152,-0.031154,0.038956683,-0.08977061,-0.004959545,-0.020409979,-0.01297889,-0.022483792,0.034965087,0.0175434,0.005854973,0.03118044,0.023469264,0.054353885,0.04017065,0.038364924,-0.04520759,-0.13765632,0.028188305,0.07581835,-0.0006212897,-0.0068798293,0.08792121,0.017200582,-0.058699917,-0.026592646,-0.099488884,0.0053296536,0.058416482,0.09295747,-0.0030408262,-0.032963432,-0.045701057,-0.044010464,-0.020700542,-0.04583903,0.014712033,-0.09664501,0.004063308,0.07390386,0.037947368,-0.07745168,-0.042800523,0.006075941,0.055826876,-4.6780465e-33,0.07018811,-0.033511676,0.0462825,-0.021252545,-0.10377471,0.03929369,-0.012681915,-0.04913067,0.049231764,-0.06722993,0.003492654,0.014910229,0.042814728,-0.042867407,0.01759032,-0.0034096045,-0.02290456,0.0342871,-0.016596079,-0.034577705,0.010289032,0.043820493,-0.012161859,0.018008502,0.06291442,-0.023862896,-0.0383624,0.07282485,0.0021872632,-0.071675144,-0.0049180835,-0.030762635,-0.00039261405,0.042213097,-0.036922313,0.048152745,0.010399683,-0.010330172,0.104837306,-0.05077488,-0.0077667465,0.07544416,-0.024561968,0.06101981,-0.013202858,0.07874434,-0.07635171,0.0954884,-0.0021954563,-0.022916641,0.03887248,-0.054389894,-0.020694166,0.049801026,0.03231896,-0.019672347,-0.0054907245,0.044836473,0.015957141,0.019671638,-0.023610912,-0.028767671,0.022611996,0.056072615,0.039770283,-0.020496804,-0.046962686,0.09341893,0.00851038,-0.06150184,0.061052073,-0.0453781,0.021476112,-0.026309976,0.05842774,-0.04314614,-0.096139364,-0.01844652,0.0074654617,-0.0052653397,-0.11686513,0.0010960649,-0.049596846,-0.042030465,0.08566811,-0.030345116,0.031870525,0.08500121,0.0049457927,0.03302745,-0.0016231402,-0.06060826,-0.020059435,0.052147195,0.0606492,-4.8224514e-08,0.063935086,-0.049562555,0.030993687,-0.07077128,0.02027154,-0.034435976,0.04275919,0.015943954,0.09647674,-0.009295109,-0.0093096495,-0.00069265306,-0.02207077,-0.0038798659,0.074146986,0.0023936788,-0.1118673,0.003402619,0.018489677,0.011935641,-0.033260565,0.0048183524,-0.0636382,0.031481024,-0.04954221,-0.005709992,0.041117214,0.028611762,-0.015936812,-0.03684201,0.009331582,0.012644517,0.04636526,-0.046971075,-0.09859013,-0.047262497,0.071049064,0.033827245,-0.053824447,0.11629411,0.016154883,-0.059189316,-0.016178869,-0.038292244,-0.05202071,0.04567114,0.006615968,0.07185493,-0.02976893,-0.09844798,0.059074562,0.043132722,0.019756678,-0.034351178,-0.12634699,-0.03590185,-0.07033185,-0.063751586,0.033219274,0.05258888,0.003691188,-0.025306221,0.13851081,-0.07695914 +3.4.11.24,"Aminopeptidases are associated with many biological functions, including protein maturation, protein degradation, cell-cycle control and hormone-level regulation [3,4]. This enzyme contains two zinc molecules in its active site and is activated by Ca2+ [4]. In the presence of Ca2+, the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe [3]. Peptides with proline in the P1' position are not substrates [3]. Belongs in peptidase family M28. ",384,0.99999994,-0.038361363,-0.094496354,-0.0521739,-0.0619137,0.101467185,0.1078412,0.025147362,0.11240267,0.049964096,0.07189001,0.02273553,0.0011170354,0.009456148,0.07452259,0.0038260214,0.031219967,-0.06605969,-0.042226672,-0.018467078,-0.066835456,0.09964416,0.025227658,-0.015717817,-0.010254602,-0.04411957,-0.051635575,0.014657625,0.0014981473,-0.0022063872,-0.0026401726,-0.025686923,-0.062414095,0.0057017654,-0.005767981,0.049195837,0.010062731,-0.050963894,-0.04915661,-0.020667508,-0.061443236,0.06947192,0.08290798,-0.07322525,-0.08753614,0.031047251,0.010161613,0.036315262,0.008625049,0.026028108,0.01738037,0.013899265,-0.051236745,0.021284563,0.050354905,-0.011464604,0.09426266,-0.05128432,-0.037145466,0.037568893,-0.04276793,-0.04491242,-0.025679477,0.037017215,-0.023919242,0.05823745,-0.0136286905,-0.020853546,0.0053687165,-0.027829673,0.008905837,-0.06622467,-0.052509245,-0.027684618,0.07799972,0.052776147,0.036238257,-0.011056958,-0.04337424,-0.07797608,-0.10397579,0.005404162,-0.010984534,0.05054844,0.08033397,0.07078295,0.040269475,0.02837953,0.025403308,0.012548734,-0.054133583,0.0602109,-0.013338668,0.05233356,0.023348821,-0.104275264,0.005097183,-0.034497585,-0.07284474,-0.02767866,0.010072539,0.028063798,0.05074407,-0.007750862,-0.08101002,-0.034295823,0.12277668,-0.0016077561,0.06641357,-0.023370363,0.02659625,0.037756212,-0.019886203,-0.0118847145,-0.008833007,0.026125511,0.029709175,0.0071861255,0.009640727,0.009188946,-0.050086517,0.0028139215,-0.029400729,0.040644977,0.038177565,-0.081103384,0.07765579,-0.06366434,2.763547e-33,0.037086092,-0.029481547,0.039879758,-0.027349805,0.089175425,0.018625464,-0.03617811,0.018636107,0.07267495,-0.056127623,-0.08832659,-0.11359295,-0.0019689258,-0.02402913,-0.04343853,-0.036836617,-0.01962755,-0.004838356,0.04661081,0.06903215,-0.020214314,0.03885111,0.037998978,-0.030294836,0.13322695,0.012592435,-0.010435535,0.0018775808,-0.028925726,-0.026598094,-0.011143868,-0.065341756,-0.112263836,-0.032512493,0.04794507,-0.009096538,0.07608186,-0.07033982,0.0050109383,0.054643836,-0.028020188,-0.05144996,0.0021338374,-0.0022650266,0.07232034,-0.085373044,-0.048686355,0.0847596,-0.012687147,0.044133358,0.027519114,-0.028596858,0.06934225,-0.04360416,-0.10480457,0.010465232,-0.057411615,-0.047311965,0.053428203,0.03561777,0.04805648,-0.015130265,-0.05573554,0.013054605,0.024192473,0.03261998,-0.068486564,-0.045056943,-0.011448431,0.08732091,-0.062063262,0.003943003,0.12099312,0.031169897,0.0507503,-0.096228756,-0.10779995,0.04787831,0.025004892,0.04015083,0.03172129,0.033064954,-0.047468733,0.019943284,-0.016154269,-0.06407957,0.054503635,-0.10331369,-0.022474965,0.01319582,0.043951757,-0.00029723224,0.012844112,0.061606992,-0.08965572,-2.9243809e-33,0.030931802,-0.03466392,0.054974977,-0.02130491,-0.051089294,-0.0012359159,0.0033243063,-0.013436913,0.041738912,-0.067019366,0.09019497,0.0026765254,-0.0068225013,-0.051100627,0.031303186,0.03800205,-0.07432957,0.0936049,0.05339876,-0.06529378,7.216275e-06,0.02185622,0.06124502,0.01898608,0.085194394,-0.01842491,0.00426803,0.10581824,0.10913615,0.040120143,-0.0023482773,0.12002422,-0.035574477,-0.058297697,-0.080057,0.019850755,-0.0730439,-0.017631296,0.0153329335,0.01873479,-0.005779418,0.06267734,0.017649269,0.049290642,0.0020359422,0.08684308,-0.013932852,0.07155246,-0.007375877,-0.04505911,0.022630876,-0.066704966,-0.013498861,0.010750916,0.065994896,0.033608906,0.022825252,0.024948072,-0.046519004,0.0058750478,0.0060438714,-0.02789553,-0.010419941,0.03268473,0.033816483,0.057631318,-0.010237029,0.04618038,0.04967778,0.032761484,0.056699485,-0.023346208,0.017630717,0.025829969,-0.064871654,0.045238346,-0.07014215,-0.022441477,-0.013585061,0.0046531013,-0.03860761,0.0060351645,-0.051610775,-0.06574654,-0.018212143,-0.007157576,-0.014302509,0.07887582,0.031714417,-0.004540658,-0.06066895,-0.031223733,-0.00830694,0.07248379,-0.026544342,-4.7103242e-08,0.09797316,0.0029917385,0.042254034,-0.091745116,-0.052266624,-0.04134491,0.022219725,-0.0747794,0.0128949685,-0.08302668,-0.025406227,0.030880641,-0.046074856,0.028818393,0.03613812,0.121295005,-0.025710475,0.0685989,-0.03225221,0.0075928224,-0.061677523,0.03947917,-0.11907664,0.038593773,0.016355313,-0.047607854,0.027435409,0.11317121,-0.005820892,-0.0237819,0.0072713504,-0.019388357,0.036032546,-0.065679654,0.056676485,0.046829797,-0.06392336,-0.0294621,-0.007863078,-0.021241307,-0.033300083,-0.0520643,0.015033899,-0.03727918,0.020629203,-0.035638046,0.028547863,0.052475274,-0.03987059,-0.036738154,-0.029400367,-0.024935778,-0.018910788,-0.107767075,-0.11686266,0.036389507,-0.044083145,-0.0829391,0.001223453,-0.090835564,-0.020830344,0.026082234,0.15177335,-0.0042122207 +1.3.1.82,"The reaction occurs in the opposite direction to that shown above. The enzyme participates in the menthol-biosynthesis pathway of Mentha plants. (+)-Pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates. The enzyme has a preference for NADPH as the reductant, with NADH being a poor substitute [2]. The enzyme is highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product. It is a member of the short-chain dehydrogenase/reductase superfamily.",384,1.0,-0.032364644,-0.0071128653,-0.109279975,0.0017035021,-0.00040192858,0.0722735,-0.10233597,-0.012120591,0.035800267,0.007627066,0.053693198,-0.02633381,-0.052248895,-0.02862883,-0.053131092,0.016065659,-0.06751069,-0.018372534,0.06299738,-0.06940485,0.07564136,-0.0022387952,-0.05359404,-0.05287799,0.05695865,-0.032497518,-0.046764005,-0.01611352,-0.021188935,-0.086174026,-0.032715295,-0.037465815,0.041161712,-0.036785096,-0.0066910135,0.108833134,-0.04482054,0.00060938764,0.027055651,0.015637187,0.016982114,-0.03491455,-0.067666925,0.005487271,-0.046914574,-0.0027911118,-0.032456756,0.053731408,0.040476378,0.052178927,0.0021338603,0.004464547,0.024875587,0.03649867,0.073370054,-0.03296085,0.0018687656,0.059390333,-0.039876904,-0.03858481,0.069176234,-0.081200786,-0.06936979,-0.0046706544,0.013288386,-0.08600494,-0.0024443255,-0.052058734,-0.0011983963,-0.037082516,0.0027533008,-0.06204549,-0.03766154,-0.0414347,-0.01845015,0.0597046,-0.12060737,-0.042296357,-0.0063384296,0.009703863,0.103644796,0.04905909,0.03394298,0.07960288,0.04078664,0.03037191,0.008504058,0.00025147016,0.0218246,0.01973777,-0.0075101564,-0.07009696,-0.01716909,0.027047036,-0.0653619,0.055478185,0.023469735,0.021518935,-0.03612379,-0.056989897,0.043575443,0.034836326,-0.035568282,-0.0853503,-0.0655918,0.05191766,-0.07410879,0.087169476,-0.006580385,0.0009383742,-0.0347883,0.016815191,-0.009765748,-0.011201046,-0.032762963,0.085112475,0.027731892,-0.024797766,-0.123643234,-0.058374103,-0.006673121,0.071330406,0.0132338945,0.062112153,0.034928262,-0.008821184,-0.11706954,5.317787e-36,0.045002118,0.09647468,-0.027040582,-0.054569237,0.034789965,-0.0004147365,-0.07111882,0.037489284,-0.009747327,-0.030566521,-0.02019048,-0.059288103,0.0032045636,-0.014153582,-0.036954895,-0.052253734,0.03892794,-0.052293684,0.04213677,-0.0067645856,-0.060122557,0.081780605,-0.10101961,-0.019319708,-0.008679245,0.03161203,0.026212435,0.030966522,0.0011395902,-0.009778835,0.020717243,-0.052481078,-0.045798227,0.019390685,0.103314,-0.0052555646,-0.016197454,0.011567306,-0.025251117,0.055736423,-0.0356537,0.06179201,-0.038217638,-0.04051138,0.09804715,-0.1039219,0.0006168702,0.08743424,0.066200346,0.0611781,-0.026055852,0.013966919,0.11203916,-0.012226695,-0.051897228,0.052579626,0.0357259,0.016140291,-0.013346823,0.120491795,-0.0007483032,0.008012117,-0.016850678,0.043424528,-0.063782975,-0.0049727014,-0.10133314,-0.072405316,0.0012963465,0.10585839,-0.036185604,0.017061252,0.027872657,0.059374053,0.042250335,0.01725501,-0.030164761,0.034484275,0.05664412,-0.02345645,-0.034740858,0.030662967,-0.073137954,-0.00949912,-0.065664545,-0.012629345,-0.022713512,-0.07148362,0.019085264,0.038583484,0.09252754,-0.04298177,0.0020928024,0.047127366,0.08030437,-1.9934053e-33,0.10357088,-0.09145973,0.08014863,-0.108684324,-0.001306679,0.11419713,0.037679248,-0.03261757,0.021255126,0.049259957,0.028169908,0.031421628,-0.032420646,0.0644042,0.023030868,-0.018347511,0.039029025,0.09588607,-0.025925979,-0.029273227,-0.0027596005,0.14550018,0.03127513,-0.012917158,0.017516878,-0.028412998,-0.0030256514,0.053654037,0.0542472,0.07889947,0.010404395,-0.075052634,-0.08195722,-0.0016027039,0.022848956,0.06851347,-0.12786621,0.051315516,0.035280872,0.08856524,-0.02559701,-0.0055127735,-0.02600385,0.021901214,0.13147047,0.0009269328,-0.105971605,0.06422392,-0.012823747,-0.1299888,-0.013644992,0.038577247,-0.016008634,0.016054608,0.07019962,-0.007835783,0.006619595,-0.011067197,0.027327178,0.00045796047,-0.016994186,-0.00058487436,-0.014883551,0.014269869,0.006444664,-0.0032942651,0.026066797,-0.0073387036,0.03884284,0.0122050205,0.073693864,0.0060077216,0.0032122354,0.06610695,-0.012813106,-0.07631551,-0.0991164,-0.039912056,-0.0077792956,-0.060637906,-0.028483741,-0.00074551033,-0.014973289,-0.05437349,-0.027512768,-0.055167,0.04500137,0.07495141,-0.023888802,0.05757341,-0.00923958,0.049121145,-0.060858708,0.0810283,0.0381585,-4.168366e-08,0.027109275,-0.06081338,0.06752328,-0.08906326,0.00860537,-0.021987112,0.015516199,-0.006651556,0.049135946,-0.031529438,-0.04995026,0.104724646,0.061022036,0.029258879,0.05744252,0.031142237,0.042671196,-0.003003269,-0.005162676,-0.02943428,-0.06397907,-0.03801203,-0.12701887,-0.0020724167,-0.036737196,-0.059296813,0.03269452,0.036907416,-0.012652476,-0.042236805,0.08994589,0.053892884,-0.0061571,-0.062421527,-0.044701677,0.049198743,-0.017872464,0.056852385,0.071157336,-0.005338649,-0.0035367836,-0.055190455,0.0063425004,0.066080816,0.0078466255,0.026188957,0.048928235,-0.046651877,-0.03900779,0.01986388,0.0070567657,-0.016787723,0.017590571,-0.06969566,-0.077253416,0.00010820151,-0.027483106,-0.03328326,-0.013667967,-0.05232659,0.00302419,0.015962446,0.12185437,-0.02058408 +1.14.19.5,"The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0) [4], that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0) [5], while that from the moth Spodoptera littoralis accepts both substrates [1]. The enzyme contains three histidine boxes that are conserved in all desaturases [2]. It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase.",384,0.99999994,-0.10819303,-0.041463766,-0.117741644,-0.014676369,0.022895033,0.040774584,-0.08873315,-0.004745339,-0.004193118,-0.0215027,0.06973309,-0.08802375,-0.09494573,0.022985492,0.004652275,0.051736493,-0.046494048,-0.016155086,-0.01905365,-0.032801434,0.13548495,0.031626083,-0.07331937,-0.024121957,-0.049305256,-0.014034852,-0.00067225273,-0.046749897,-0.0167649,-0.072383106,-0.027452426,-0.015445053,0.06564244,-0.035330962,0.04440777,0.0481464,-0.04431323,-0.08448021,0.0955519,-0.005664485,0.08090624,0.016924106,-0.024946585,0.0206539,-0.045881767,-0.0983564,-0.025754368,0.044691823,0.002920282,-0.04719551,-0.03803135,-0.040432483,-0.02955054,0.08844075,-0.061241902,0.015100349,0.0333172,-0.034653835,-0.009415827,0.01727822,0.07595782,0.046794824,-0.013142372,-0.018174885,0.022720829,-0.1110057,-0.021617314,-0.029476887,0.08035995,-0.016316094,-0.03111146,-0.052283466,-0.0067222035,0.058484387,0.033164456,0.009319661,-0.0044619883,-0.023327136,0.009483899,0.015489588,-0.084998496,-0.03025465,0.045058053,0.1416597,0.06958893,-0.05793267,-0.012127357,0.009326052,-0.0062774112,0.042564504,0.05501557,-0.044464014,-0.05059518,-0.016775168,-0.14697006,0.067693666,-0.004579484,0.016782187,-0.053120255,0.0034202433,0.046866816,0.0091332495,-0.11368267,-0.09387429,-0.068017565,-0.009310457,0.020755239,0.04293067,0.00845527,0.009356963,-0.05073782,0.004107736,0.025050923,0.056262597,-0.04253341,0.02425454,-0.03503115,-0.043399546,0.0880447,0.020951312,-0.012707702,0.0035361322,0.043129895,0.061771803,0.036488723,-0.03320104,-0.14339364,2.6874696e-33,0.024902701,0.02531431,0.017043363,-0.016820434,-0.039699905,-0.0949036,-0.04010863,0.021227501,-0.088851094,-0.015714323,-0.024666572,-0.023595072,-0.00248448,0.051399846,-0.032630127,-0.009222596,0.05466082,-0.054628473,0.097512215,0.0324364,0.0029108203,0.0935322,-0.016639005,-0.049536265,0.115450755,0.070357084,-0.06577609,0.011258372,0.014950146,0.037316453,0.037277896,-0.0681069,-0.050072912,0.08324629,0.12362192,0.052819416,0.003488944,-0.042499937,-0.09308797,0.06895592,0.040837213,-0.022991173,-0.00011415237,0.0007582805,0.062261686,-0.056285538,-0.09577811,0.09290321,0.051979013,0.012832866,0.02788947,-0.021666918,0.11042255,0.033410747,-0.072627075,0.052110333,0.0052140085,-0.031413108,0.037806768,-0.018234847,0.021347212,-0.009962864,-0.0129930945,0.0038227604,0.0774956,0.039839428,-0.0879043,-0.034224737,-0.051934622,0.07089041,-0.06388907,-0.021683542,0.036975205,0.052689992,0.05014322,0.019466948,-0.02483962,0.067318335,0.0068247993,0.015170429,0.05937684,-0.041451417,0.008320869,-0.044096105,-0.092217706,-0.045639843,0.02563548,-0.017831882,0.05704104,0.06340518,0.017744105,-0.09001268,0.013202859,-0.012247104,0.0060370252,-3.8566636e-33,0.04695681,-0.09583287,0.041800763,-0.09013271,-0.045032565,0.051854223,-0.016825566,-0.014600384,0.006463455,-0.0055181608,0.07410546,0.01826191,-0.03349807,-0.039483186,-0.04227825,0.09332197,0.0643824,0.06287932,0.024512993,-0.06421442,-0.047691956,0.1298376,0.034611993,0.051420435,-0.009518267,-0.049290124,0.06737572,0.10438552,0.030147795,-0.0079235155,0.009605619,0.0012515392,-0.034175295,-0.07405498,-0.059254248,0.0010316519,-0.12018234,0.0022039476,0.058088787,0.08961947,0.004736468,0.01593306,0.023261387,0.029965715,0.041486565,0.015251387,-0.09724065,-0.01908456,-0.004180764,-0.07012523,0.013871134,-0.012102376,0.0020343673,0.005593172,0.054391176,0.05204329,0.012763439,0.018070785,0.056740124,-0.03456215,0.010863166,-0.03449722,-0.05362535,0.00030925727,0.01085361,0.030908896,-0.0650553,0.024264373,-0.012417546,0.050835103,0.05090094,0.042535845,-0.030956557,0.022006396,-0.1225737,-0.039710164,-0.009503846,-0.023259025,0.028304704,-0.012935369,-0.005509938,-0.00889019,-0.02476957,-0.08526841,0.030131634,-0.01264956,0.023594076,0.088964164,-0.009274211,-0.019381681,-0.0030056734,-0.021271601,-0.03466754,0.022373922,0.041890334,-4.5248914e-08,0.047675367,-0.06204095,-0.0270866,0.006876927,-0.04674136,0.007099257,-0.028985685,-0.12695003,0.028376007,-0.014217556,-0.015030068,0.039597236,0.04805042,-0.024446648,0.040371478,-0.008543005,0.061546233,0.02160444,-0.0002935168,-0.030997152,-0.004005706,0.024800405,-0.113476805,0.020106396,0.051332615,-0.011792115,0.081394404,0.038137957,0.027789362,0.038574215,-0.004353641,0.04814849,0.045244265,0.023514615,-0.011905374,0.008206599,-0.01891994,-0.085370235,-0.0014241699,0.028693683,0.070025355,-0.020812066,-0.037700247,0.010099667,0.032419905,0.015331654,0.08902127,0.054725654,-0.010464138,0.055043526,-0.013152229,0.04714621,-0.04678262,-0.01842909,-0.08845042,-0.0042637093,0.017727312,-0.032669347,-0.069103345,-0.022608513,0.06845764,-0.02141735,0.12866408,-0.03231853 +1.14.19.6,"This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. When acting on 19:1Delta10 fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, towards the methyl-end of the fatty acid. Requires cytochrome b5 as the electron donor [4].",384,1.0,-0.11039407,0.0034813334,-0.13141336,-0.024097186,0.005593749,0.0020795327,-0.06486338,0.031017823,-0.015413486,0.00028097903,0.13301751,-0.1308428,-0.04291768,0.079990685,-0.026758233,0.004836791,-0.0225914,-0.027911177,-0.0078557795,0.0028285333,0.0014763137,0.06658317,0.04249188,-0.018982746,-0.05279097,-0.038816635,0.033799056,-0.008425208,-0.017085714,-0.005095791,0.0006511959,-0.029507948,-0.009594829,-0.044590157,0.045869283,-0.025542906,0.023920821,-0.013369719,0.030597663,-0.017299049,0.052102685,-0.07309143,0.025465114,-0.014617371,0.0013426611,-0.103732534,-0.011157471,0.047518753,0.11438929,-0.029893558,-0.057253834,-0.06153695,-0.085092604,0.0502003,0.0042636218,0.044241875,-0.03236831,-0.041601177,-0.032218575,0.033709448,0.037278708,0.008997951,-0.026152367,0.02806233,0.03781745,-0.07902975,-0.055537708,-0.05878779,-0.017835844,0.02294987,-0.01853189,-0.10249286,-0.05415826,-0.023035135,-0.037097376,0.06541835,0.024774652,-0.058259692,0.034488387,-0.023471259,-0.04363264,-0.017635707,0.10444055,0.06323599,0.01499233,0.010895744,0.015979437,0.053372603,0.015991686,0.063382655,0.065558,0.034265235,0.008762529,0.06548353,-0.13535205,0.035956733,0.020358155,0.043919325,-0.012537972,0.013376976,0.076911695,-0.03747596,-0.02649388,-0.11098266,-0.037548866,-0.020261206,-0.01912838,0.08100826,0.06614086,-0.0073320074,0.022658387,0.003896842,-0.00515043,0.0007596667,0.014121266,0.036530413,-0.0038651596,-0.018995926,-0.004932848,0.0075426786,-0.04469154,0.014190049,0.021409472,-0.03157963,-0.0075209886,-0.0040051653,-0.09428224,2.966156e-33,-0.00702806,0.02982517,0.024038471,0.04435926,0.010731189,-0.018443098,-0.10017811,0.019124089,-0.15740815,-0.056160063,-0.0295883,-0.07489346,0.027896928,0.061337676,-0.078878924,-0.0705799,0.02073254,0.016637437,0.080278076,0.03801501,-0.051346786,0.08145195,0.038756683,-0.094978236,0.07240101,0.050822034,-0.05179636,0.040175524,0.012123894,0.0271702,-0.06274911,-0.013520333,-0.119360104,0.032176714,0.08493048,0.056868464,0.07786111,-0.004975631,-0.106106214,0.011859139,0.03526908,-0.0045347735,-0.051801447,-0.026698057,0.11633777,-0.050447218,-0.05928333,0.088996634,0.03824636,0.021123266,0.0013631198,9.6049946e-05,0.063461274,0.07623084,-0.13699056,0.06625978,-0.016161915,0.0168381,0.026598267,-0.045307342,-0.0025634405,0.06586918,-0.07185787,0.08357119,-0.016877623,-0.027567843,-0.0062757395,-0.0687436,-0.05093473,0.08223205,-0.018130075,0.0081041185,0.09867547,-0.018745152,0.034445293,-0.0014473818,-0.037879102,0.010599973,-0.005067571,0.049466453,-0.010828539,-0.045178946,0.056362014,-0.060082864,-0.10506473,0.062615246,-0.007087413,0.03625428,0.0790388,0.018295506,0.09042604,-0.12018581,0.0026790379,-0.00353489,0.011444507,-4.0495795e-33,0.11212727,-0.07787437,0.032698642,-0.122798875,-0.03933515,0.00552107,-0.0061003724,-0.088403605,-0.0031429434,-0.034603935,0.15573698,-0.036784925,0.040924516,-0.037661448,0.027898347,0.0077430517,-0.02153289,0.041176308,0.07573413,-0.03105363,0.046273075,-0.011121624,-0.024785021,0.064731866,-0.0056432514,0.026979223,0.053565867,0.051317684,-0.023485051,-0.019528897,-0.053460486,-0.045951504,-0.039861877,-0.04047545,0.029926674,0.030167347,-0.049963478,-0.0032180334,0.06058956,0.029128766,-0.028584741,0.03843314,-0.029125918,0.048135545,0.017233813,0.059526403,-0.06790457,-0.028105168,-0.018939994,-0.06492978,0.018765114,-0.013037394,-0.0011231822,-0.0018351927,0.0438699,0.041797813,0.01569784,0.01838983,0.043199327,-0.031636503,-0.03578556,-0.0148988785,-0.04960056,-0.048365258,0.0911173,0.050724674,-0.07568869,-0.029858377,0.015508256,0.01128757,0.026178015,0.039274406,-0.009761068,0.036755033,-0.059477337,-0.023398535,0.044216216,-0.087911956,0.014038897,0.0061682,0.015084621,-0.06096845,0.05610168,0.014298297,-0.019867463,-0.05350892,0.039647724,0.057480562,-0.033596247,0.03758843,-0.008539709,0.05197091,0.001488529,0.05883087,0.035696406,-3.792297e-08,0.007951049,-0.08797948,-0.03645412,-0.06541433,0.021657996,0.017501006,-0.041567087,-0.06761668,0.12314374,-0.017859085,-0.033754874,0.051675666,0.042942427,0.048471157,-0.02157282,-0.0027046895,-0.005121164,-0.03990157,0.00089104817,-0.10184181,-0.08507506,0.037228603,-0.0073015965,0.0021503738,0.008934441,-0.0318675,0.0008827916,0.08883734,-0.010729608,0.024253603,-0.09348359,-0.021657107,-0.032777537,0.054970764,0.035355333,0.027333895,0.0014233796,-0.04453813,-0.0010848627,0.03784787,0.100826465,-0.059719566,-0.046252675,0.0069489456,0.009778082,-0.032639448,-0.0019462575,0.06520163,0.0019504707,-0.042196866,0.00090203976,0.099416874,0.0072036916,-0.02220221,-0.058323864,0.02536664,-0.0035452459,-0.00939168,-0.05649008,0.05944768,0.0649125,0.01920683,0.10126988,-0.048161954 +1.13.12.15,"This enzyme is one of the three enzymes involved in L-dopa (3,4-dihydroxy-L-phenylalanine) catabolism in the non-oxygenic phototrophic bacterium Rubrivivax benzoatilyticus OU5 (and not Rhodobacter sphaeroides OU5 as had been thought [1]), the other two being EC 4.3.1.22 (dihydroxyphenylalanine reductive deaminase) and EC 2.6.1.49 (3,4-dihydroxyphenylalanine transaminase). In addition to L-dopa, the enzyme can also use L-tyrosine, L-phenylalanine, L-tryptophan and glutamate as substrate, but more slowly. The enzyme is inhibited by NADH and 2-oxoglutarate.",384,0.99999994,-0.052982196,-0.09009255,-0.072737485,-0.024712909,0.028589634,0.018551324,-0.09637425,0.053197723,-0.0049444246,0.0023158882,0.031044805,-0.007135288,-0.013033673,0.096353345,-0.02443642,0.10712443,-0.07992282,-0.017262908,0.008539752,0.012028424,0.08483712,0.010844018,-0.058591366,-0.031346697,0.050404206,-0.02645747,0.021769686,-0.037949923,-0.03590697,-0.019163415,-0.01883437,-0.05701995,0.015015794,-0.07157011,-0.0017942134,0.02341596,-0.085160136,-0.09031715,0.092571914,0.059040952,-0.015675161,-0.029087583,-0.04594455,-0.06860731,-0.0019241574,-0.023253676,0.04230956,0.010737453,0.014725129,-0.011719507,-0.057804145,-0.03046005,0.001127865,0.028719572,-0.026534645,-0.06898698,-0.04534981,0.057233755,0.01753235,0.022021305,0.02815527,0.03645178,-0.010766215,-0.02429747,-0.011295055,-0.03799435,-0.009864117,-0.08919317,0.01867317,-0.049102545,-0.072640404,-0.06678845,0.060298383,0.032461382,-0.036087003,0.016103562,0.08041009,0.074088566,0.064101,-0.06932,0.079947986,-0.013421327,-0.056864083,0.11568948,0.023513693,0.012566555,-0.015131298,0.03871476,0.043200634,-0.025930416,0.024367549,0.046511203,-0.096478306,-0.079572745,8.641997e-05,0.007067308,-0.050142445,0.032582335,-0.029637937,-0.008341889,0.005286633,0.026749313,-0.039432455,-0.09768383,-0.11708871,-0.053623326,0.03317243,0.06585084,0.03311421,-0.038213443,0.08199213,0.033667818,0.026867177,-0.027265351,-0.044718396,0.09127828,0.07195415,-0.11892035,-0.09633799,-0.02277858,0.017810738,-0.04466344,0.12896894,0.05792542,-0.015482397,-0.020380408,-0.066166796,5.325289e-33,0.10143289,-0.0022932135,-0.040434465,0.0048091006,0.032007243,0.0376841,-0.07538679,0.07432216,-0.0717843,-0.05685634,-0.079009734,-0.047988318,0.038957123,0.012576369,-0.034607477,0.03541795,0.021900488,-0.03791425,0.020472044,0.038862333,0.07781546,0.026959734,0.0031863332,0.09362139,0.041492805,0.046254303,0.006889844,-0.071450256,0.001358133,-0.022079302,0.03673523,-0.158111,-0.06536807,0.03640833,-0.037971124,-0.031216599,-0.10233376,-0.01517872,-0.0062357234,-0.0056918627,0.022959402,0.0678955,0.010521758,0.01615385,0.0774503,0.022072833,-0.00743715,0.042567704,-0.010390144,0.08781063,0.07447235,-0.038631067,0.056700755,-0.04908247,-0.09460817,-0.01308993,-0.06801575,0.02526909,0.015469407,0.02617523,0.055300992,0.07006897,-0.028138056,0.033190522,-0.015240034,0.011429906,-0.029617412,-0.006075865,0.01228822,-0.017790442,-0.063209064,-0.016070995,0.084242955,-0.021565719,0.012304027,-0.05945757,-0.0085379,0.032634772,0.027300507,-0.013729435,0.017949987,-0.07634851,0.064772464,-0.022926498,-0.01758109,0.019060263,0.017838284,-0.033044662,-0.071444996,0.018821029,0.042395905,-0.07200868,-0.064612485,-0.0060144127,0.017234132,-5.4808868e-33,0.108185075,-0.10156082,0.019720268,-0.10918696,-0.005293091,0.05869818,0.027081102,0.018350312,0.016340634,-0.08514777,0.07340764,-0.020640248,0.02969102,0.012325122,0.055346813,0.009783372,-0.058812685,0.04793879,-0.022185743,-0.019346671,-0.029333819,0.06285665,0.062090103,0.01929995,0.06533499,0.04884269,0.022923205,0.0480572,0.039850667,0.0495917,-0.01902618,0.033865403,-0.009473362,-0.028269436,-0.017058488,0.050345853,-0.06859753,-0.011973194,0.043602373,0.041149933,0.01995966,-0.027584204,-0.025659261,-0.001368933,-0.05121199,0.060539994,-0.12520987,-0.01649581,-0.04458247,-0.070120335,0.03761847,-0.003930353,-0.026983159,0.018472385,0.025025126,0.056454983,0.011975353,0.030135067,-0.013139294,0.02469404,-0.031410392,-0.10709395,0.028158326,0.06600222,0.026776915,0.12627631,0.043377757,0.08323203,-0.0010346932,-0.033134278,0.05462873,-0.01325161,-0.019995974,0.061727956,-0.050949484,-0.0022223562,-0.029460412,-0.02199484,0.027602285,-0.05707659,-0.014019428,-0.082848765,-0.028955612,0.0101016965,0.059567958,-0.04479404,-0.024274882,0.06924334,0.047566414,0.01994327,0.006871361,0.02341269,-0.0065629906,-0.012739102,0.14129046,-4.864728e-08,0.031477995,-0.06899733,0.03772184,-0.0040619783,0.025278755,0.00815208,0.053785082,0.055111818,0.0024275891,-0.0094380155,0.046150576,0.022953685,-0.058051627,-0.052483432,0.095370024,0.014832011,-0.067513876,0.036123097,-0.024987876,0.048111413,-0.06289592,-0.07730548,-0.11265556,0.02517901,0.024878705,-0.08156861,0.0029829035,0.023454899,0.06305505,-0.05542485,0.034611784,0.022450259,0.04879916,-0.021324676,-0.11391914,-0.012372862,-0.062400006,-0.020821603,-0.066694155,0.064274535,-0.010186869,-0.0060973447,-0.048060667,-0.0031792629,-0.003818232,-0.002876724,0.009829419,0.025323771,0.054855134,0.017196238,0.022066846,0.035366565,-0.0040921425,-0.008220914,-0.16025828,0.00074909057,0.01082864,-0.002652587,0.014679596,0.009239163,0.013818412,0.056020547,0.15724637,-0.006124707 +2.1.3.11,"This enzyme is specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3, ornithine carbamoyltransferase) or N-acetyl-L-ornithine (see EC 2.1.3.9, N-acetylornithine carbamoyltransferase) as substrate. However, a single amino-acid substitution (Pro90 -> Glu90) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine.",384,0.99999994,-0.14476791,-0.062122878,-0.06899563,-0.060947634,0.07853458,0.08334359,-0.044843655,0.089592874,-0.019669041,-0.026451407,-0.0047477637,-0.026538888,0.011594704,0.06793903,-0.05548549,0.095230736,-0.1071158,-0.025887452,0.031496607,-0.028250534,0.08591863,0.07273462,-0.024407186,-0.04861455,0.06419285,-0.0868153,-0.0016907515,0.005901161,-0.0023823557,-0.07549034,0.025300387,-0.047297683,-0.01629943,-0.050421882,0.06537153,0.027074851,-0.06851081,-0.0458392,0.07951615,0.026567623,0.004212216,-0.0020324385,-0.14284247,-0.025536591,-0.0063280016,-0.05179511,0.007804103,0.018919557,0.04559885,-0.027973985,-0.015890433,0.00389213,0.006113764,-0.0022765317,-0.01573826,-0.015799034,-0.08005067,-0.10343708,-0.008488663,0.05578238,0.007145171,0.023395712,0.012468579,-0.05605695,-0.008246034,-0.042209916,0.052183885,-0.10283853,0.02668031,0.034061387,-0.046387676,-0.03755875,-0.044802446,0.107134216,0.01987484,-0.004233082,0.0074123787,0.037586357,-0.02138369,-0.020824397,0.026867824,0.026948608,0.023243997,0.0616652,0.04947281,-0.08305118,6.6843815e-05,0.084422745,0.07806437,-0.006863254,0.006936638,-0.024767604,0.035114042,-0.018787213,0.0057960358,-0.007678576,-0.021563016,-0.0018692594,-0.01072266,0.011904249,-0.00653904,0.027152106,-0.014571597,-0.060656913,-0.00535191,-0.006276709,0.085091166,0.08612585,0.033835713,-0.08117954,0.007897732,-0.014045808,0.03379038,-0.042954203,-0.10192229,0.050238498,-0.039420955,-0.061861765,-0.0045430544,0.015227153,-0.0075982884,0.0047469893,0.005418882,0.10343656,-0.016260112,0.15122782,-0.11446819,5.7922187e-33,0.047925923,0.041643377,0.022142516,0.010895749,0.012446208,0.024496518,-0.09916452,0.03439827,0.038529295,-0.11925033,-0.022149054,-0.12719746,0.030748647,0.02779737,-0.03287808,0.0046915254,-0.010182018,-0.035504345,0.0291648,0.026417915,-0.056012917,-0.010996502,-0.07106242,0.03796841,0.041525975,0.060763758,0.07940814,0.014383561,0.014702978,-0.022881221,0.046353377,-0.08153899,-0.05640785,-0.0011614693,0.026121678,-0.038488675,0.06887617,-0.03306044,0.008599328,0.06077103,-0.04152107,0.09435868,0.0032689422,0.004609508,0.07247386,0.004769664,-0.020817852,0.10557268,-0.03704551,0.06342315,0.07511902,-0.0004083434,0.031082945,-0.036255576,-0.057522397,0.044031076,-0.03353531,0.016619269,0.07624592,0.01717774,0.09901755,-0.023492096,0.05125845,0.035061672,0.023121394,0.039633065,-0.061015166,-0.02887776,0.03147158,0.056961294,-0.082410954,0.011214752,0.06624856,0.04983649,0.03396308,-0.030592276,-0.054391284,0.037029903,0.058736566,-0.03777691,0.0028749693,-0.0062356032,0.032166403,-0.02729502,-0.033762176,-0.07382147,0.006191009,-0.068003535,0.01745735,-0.0075628767,0.04667031,-0.027084634,-0.058193278,0.017003542,-0.051214993,-4.9175385e-33,0.062021054,-0.09845443,-0.0018672193,-0.045197394,-0.074720666,0.061106313,0.04145087,-0.041585118,0.03483662,0.039988983,0.069995105,0.0047043874,0.08458092,-0.051796522,0.02780827,-0.039389737,-0.028595291,0.05596772,-0.03633207,0.0510663,-0.03913877,0.08129252,0.020870624,-0.004498364,0.018297948,0.035761185,-0.03710469,0.12315195,0.004190731,0.010652976,0.010581755,0.021816757,-0.037311178,-0.075392716,-0.030609293,0.054099735,0.087864704,-0.0013791022,-0.052403886,-0.029304946,-0.004822494,0.044135574,-0.0075010606,-0.012224814,-0.04348838,0.05257743,0.02333122,-0.08173201,-0.0023516726,-0.10341831,0.008728086,-0.02258211,0.029732974,-0.027654639,-0.04993584,0.020649318,0.0035917507,-0.012851821,0.019620508,-0.022543876,0.022956034,0.009526756,0.044985905,-0.0011648557,0.015756698,0.09452149,-0.05301339,0.04697944,0.02515771,-0.050726917,-0.042486183,-0.04870568,0.05908291,0.061366726,-0.03521357,0.054860655,-0.045297906,-0.11606051,-0.011230635,-0.068259574,-0.04879336,-0.09737214,-0.06678164,-0.034604624,-0.049080458,0.013666799,0.03428447,0.124799326,0.0102371415,0.026898678,-0.027740538,-0.009358934,-0.037082613,0.08948018,0.058207046,-4.6271584e-08,0.08758843,-0.02066961,0.008689256,-0.01207452,0.015957957,-0.00980446,-0.04853516,-0.06818041,0.039243564,-0.021493485,-0.048225775,0.051455997,-0.029049706,0.03296153,0.019172579,0.037290063,0.030570319,0.02966349,-0.0012322159,0.048253052,-0.102758005,0.0436007,-0.059023816,0.03332059,0.03451756,-0.08373312,0.053817037,0.0676721,0.09876127,-0.10342314,-0.054511458,0.08372997,-0.072322994,-0.0073185824,-0.055256527,-0.005453806,-0.060590107,-0.02644413,0.062914796,0.037131283,0.026280211,0.015438749,-0.06942281,-0.0157249,0.0125610875,-0.015089435,0.006590801,-0.047413297,-0.02299867,0.010738165,0.04647838,-0.036513783,0.025757164,-0.013925332,-0.04566502,0.015356835,-0.06122648,-0.03672872,-0.0029417535,0.0071171615,-0.015691372,-0.0017309049,0.17917769,-0.021274349 +2.5.1.72,"An iron-sulfur protein that requires a [4Fe-4S] cluster for activity [1]. Quinolinate synthase catalyses the second step in the de novo biosynthesis of NAD+ from aspartate in some bacteria, with EC 1.4.3.16 (L-aspartate oxidase) catalysing the first step and EC 2.4.2.19 [nicotinate-nucleotide diphosphorylase (carboxylating)] the third step. In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme [5].",384,0.99999994,-0.022100037,-0.03495863,-0.06062567,0.045922887,0.057540372,0.04297228,-0.04853666,0.02325271,0.049387846,-0.051448558,-0.019792,-6.496311e-05,-0.04053967,0.020809459,-0.07821096,-0.0051864777,-0.044930194,0.0154327,0.027139822,-0.04124456,0.012191821,-0.053434893,-0.017859058,-0.09925148,0.015331887,0.08100721,0.079601884,-0.037562657,-0.035889145,-0.05137699,-0.057547443,-0.042417042,0.019344315,-0.059383266,0.009528697,0.09945139,0.056730185,-0.072226025,0.037015334,-0.033359997,0.013944438,0.059702877,-0.029526506,0.009309994,-0.020392392,-0.013573857,0.04301896,0.05363378,0.022602871,-0.04881421,-0.08721896,0.015455149,-0.029293716,0.033057686,-0.010462648,0.0041476623,-0.042852197,-0.03708039,0.015763527,-0.010256046,0.066363044,-0.0653569,0.0275296,-0.03830492,0.023372147,-0.012367131,0.088712126,0.025971746,-0.0019648254,-0.037495293,-0.109791055,0.068177655,-0.009524319,0.020324597,0.031367112,0.07593597,-0.02294996,-0.034611605,0.075630896,0.027307259,-0.016005566,0.0116902245,0.009957067,0.07480795,0.027987244,-0.008838553,-0.014308953,-0.025869003,0.085751705,0.033275537,-0.03325115,-0.033433057,-0.02975892,-0.012760329,-0.094619766,0.024450181,-0.014432526,0.044909857,0.060252327,-0.043005094,0.00046557194,0.08503084,-0.044019133,-0.040582515,0.007363728,-0.0037698988,0.008057332,0.18073013,8.923467e-05,0.06540823,0.0405908,-0.02893543,0.04472679,-0.032683913,-0.05584728,0.07192125,0.026877817,-0.06696218,-0.10768818,-0.005038859,0.04420746,0.06216952,0.0026692348,0.032387543,0.018899145,-0.021002164,-0.18303409,1.9103578e-33,0.09285185,0.07748789,0.09017933,0.0804163,0.028055329,-0.018422667,-0.096311174,0.012422006,-0.050849725,0.033988886,-0.014058487,-0.111236826,0.08293093,-0.075165614,0.0045542,-0.018793143,-0.007244139,-0.01957539,0.014658131,-0.00084068323,-0.003853773,0.049588412,0.019878492,-0.038269617,0.008250304,0.093533024,-0.048867762,0.010144023,0.04679466,0.0046229116,0.033377036,-0.05686019,-0.099817045,-0.046238348,0.14040889,-0.048340116,0.046606064,-0.037680402,-0.080956,-0.003461274,-0.04139834,0.06578031,-0.011580994,-0.11774545,0.061993074,-0.12015594,0.01386216,0.059081174,0.036499467,0.014315378,-0.041913405,-0.02323222,0.1711922,-0.022834148,-0.055673487,0.014813198,-0.011171418,-0.013703126,0.041812707,0.066267215,0.043598216,0.020271638,-0.07459071,0.019614248,-0.014926834,0.037541173,-0.0025300633,-0.026212672,0.03394071,0.15641358,-0.024576887,0.013065405,0.019481996,0.020092474,-0.02690592,-0.057802938,-0.05407989,-0.002471163,0.033213478,0.010952691,0.007891569,-0.017736645,-0.02274723,0.0090562375,-0.00942582,-0.033832476,0.024139453,0.0023812638,0.03831345,0.03490714,0.004193755,-0.019847412,-0.010534083,0.013712666,-0.022850957,-3.2529496e-33,0.084726706,-0.05897492,0.011364215,-0.080086775,-0.09603888,0.06327982,-0.010683034,0.0028858893,0.010077965,0.022770524,0.06750329,-0.011180039,0.05667884,-0.05354921,-0.0048027565,0.05035083,-0.018750083,0.004336705,0.05181185,-0.016861312,-0.007694415,0.0810821,0.048760224,0.045824192,0.057834037,-0.00016212865,0.02393021,0.045484878,0.0027867982,0.08047109,-0.0027237164,-0.03099146,-0.026674777,-0.08056923,-0.058473628,0.018033883,-0.029835094,0.016177695,0.05988724,-0.012081063,-0.0015760201,-0.0042176694,-0.006873556,0.099549815,0.026257701,-0.0107887015,-0.06554766,0.09767517,-0.017279,-0.023975696,0.013591912,-0.061619647,-0.0851197,0.011599858,0.030090386,0.017871505,-0.008835321,0.0641729,0.035566125,0.022588497,-0.06654726,-0.11503287,0.036746074,-0.028674178,0.063949935,0.01963078,-0.075070314,0.040756725,0.07462786,-0.012684532,-0.038319957,0.034289323,-0.0025411781,-0.0031613202,0.03277659,-0.043629527,-0.060022626,-0.013550455,-0.013164736,0.056780994,-0.071346916,-0.0057940767,-0.01204502,-0.067326695,0.039995715,-0.06484818,0.037811756,0.15157844,-0.039287772,0.015312291,-0.027375115,-0.05938466,0.03078899,0.032952867,-0.094895735,-3.9317175e-08,-0.034906108,0.006448352,0.012785256,-0.024253458,-0.059859212,0.041962035,-0.037351318,-0.014077754,0.01218862,0.034718458,0.04272296,0.07159491,-0.0068663424,-0.009332277,0.032530554,0.015253263,-0.07115821,0.029449306,-0.050347716,0.015461371,0.0040734797,-0.0033925583,-0.107480556,0.047922798,0.089878485,-0.098212436,0.017378146,-0.06976998,-0.05877239,-0.06271495,-0.028832147,0.018410882,0.03352886,-0.018091878,-0.12034215,-0.052101713,-0.07291472,0.015919527,-0.0005279066,0.026475167,0.04569852,-0.0005390404,-0.103980996,0.028792245,-0.054482464,0.08570125,-0.009245238,0.038238227,-0.043308258,-0.020953095,0.046426877,-0.0057258643,0.030793773,-0.053673014,-0.055939794,0.034619603,0.026222166,-0.0385981,0.0748825,-0.034991685,0.03562809,-0.028772019,0.06886455,-0.04774934 +3.1.3.78,"Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].",384,1.0,-0.042776573,-0.07134497,-0.020779788,-0.048135117,0.032472584,-0.019566184,0.05177569,0.047838293,0.087588795,0.10448787,-0.045240767,0.08681097,-0.03388361,0.081444666,-0.050654776,0.03144061,-0.08261583,0.019953562,0.0017855009,-0.068989,0.018690273,-0.02674585,-0.025404977,0.02653125,-0.06169835,-0.022861375,0.0777656,-0.008201124,-0.07444308,-0.06063516,-0.070036255,-0.040796842,0.012785124,-0.06567324,-0.020109301,0.12562728,-0.03630787,-0.03764592,-0.007334562,-0.029076738,0.1038429,-0.049526274,-0.06521892,-0.022942213,0.0067011104,0.009656353,-0.030913282,-0.0069271894,0.057018824,0.022917714,-0.036665954,0.030639304,0.016598059,-0.034492504,-0.038117487,0.018206548,-0.05037785,0.11740063,0.02751383,0.036661845,-0.01960426,-0.05617516,-0.0005306834,0.047203198,0.067637004,0.039797228,0.03785869,-0.037897624,-0.02866053,0.045847505,-0.038409237,-0.013537405,0.066169605,0.004609109,0.026578527,0.046535075,0.03161643,-0.048108686,-0.054690514,-0.06130318,0.002893816,0.00078754337,0.014332649,-0.0027469166,0.04837982,0.016191842,-0.05836896,-0.00030618222,0.06505558,0.04530981,0.034132794,0.006608467,0.03183254,0.0329348,0.008714455,0.06062262,-0.011401312,-0.008419552,0.010026683,-0.057462934,-0.037571296,0.06490907,-0.09320739,-0.047189675,0.040256027,0.0764815,-0.02506627,-0.0048762383,0.01942122,0.015480969,0.0034680201,-0.031075325,0.022081204,0.00028519295,0.04758146,0.046819195,-0.030159708,-0.062042627,0.034538645,0.02792739,-0.016649486,-0.03393879,-0.028166717,0.0936516,-0.09920699,0.06492696,-0.006589623,4.7675307e-33,-0.029569201,0.01784725,0.003823977,0.033788327,0.042129688,-0.0036817256,0.008272592,-0.0345181,-0.08964589,-0.06076648,0.013951603,-0.13460691,0.031282935,-0.012998413,-0.07145412,0.014126298,0.009193118,0.052897856,0.06616423,0.016956868,0.007888584,0.03349172,-0.06385594,0.0013685849,0.0444297,0.09195447,-0.061387923,0.021766674,0.03398862,0.00093926245,-0.05783508,-0.042645667,-0.07811035,-0.0063057677,-0.050691422,-0.055811476,-0.03471096,-0.020163462,0.0047931513,0.06023093,-0.047191773,-0.036238715,-0.055784225,0.046519123,0.031982128,-0.12641837,-0.01974147,0.036325037,-0.08391337,0.022836233,0.006370896,-0.03539009,0.08297682,-0.05684142,-0.09316158,-0.091224834,-0.046715204,-0.06616075,0.074394,0.03670197,0.08108459,0.06498657,-0.043583572,0.050413962,0.03646765,0.03831047,-0.0408901,-0.08125026,-0.009534401,0.08363003,-0.010288704,-0.017046185,0.03000916,0.018611979,0.08167853,-0.009362723,0.028735887,0.06884329,-0.02370564,0.046450425,-0.022803983,-0.048372187,-0.0028047173,0.06530267,0.010689858,-0.0023200542,0.04288862,-0.1141642,0.0020789835,-0.030160414,0.0815833,-0.08448493,-0.0552806,0.06455248,-0.04648016,-6.001405e-33,0.059640627,0.020875093,0.066694595,-0.10316636,-0.15825999,0.016907021,0.060143553,-0.04988888,0.083070435,-0.02781352,0.07079195,-0.049855758,0.042642873,-0.059854154,-0.06814529,0.037947837,-0.0038995375,0.032396715,-0.0012603641,-0.01960176,0.011129553,0.079632275,-0.029139627,0.14878492,0.04460646,-0.028786773,-0.02166724,0.003614254,0.028884433,0.058988754,-0.020716654,0.027395207,-0.029395176,-0.0016963029,0.00370102,0.003725659,-0.07728828,-0.012594264,0.04165952,-0.00082204235,0.05015379,0.06841115,0.06632057,-0.026844518,-0.039306797,0.012935644,-0.022035936,0.11678654,-0.07184564,-0.058266297,-0.038907927,0.06441454,-0.01657509,0.045132957,0.0043055047,0.016332835,0.06761543,0.0060315304,0.019654185,-0.043613892,-0.04819216,-0.066568114,0.067200266,0.097526416,0.075684346,0.042231105,-0.021228306,0.028202575,-0.03876029,0.032776866,0.041748416,0.0213032,0.017388273,0.04316349,-0.027264863,0.038029425,-0.014454724,0.0065455106,0.04458158,-0.013180279,-0.018543229,-0.00023166729,-0.011518783,-0.10332855,-0.0071464195,-0.035092477,0.022747375,0.109511904,0.02727487,0.022887925,0.020760406,-0.10450434,-0.065067835,-0.022839198,0.047491744,-5.4088044e-08,0.07315463,-0.012372361,0.015038786,-0.069416456,-0.053880174,-0.061462805,-0.0036172492,0.060859002,0.053957377,-0.01458233,-0.05732472,0.015715241,0.053175133,-0.034848336,0.05635059,0.10595316,-0.017976519,-0.0018776321,0.032616347,-0.050064538,-0.06339948,-0.070652016,-0.10316364,0.037623562,0.074537605,-0.014775636,0.055266257,0.016600614,0.015092896,-0.088392526,-0.024663394,-0.03031366,-0.035136916,0.009555947,0.041923262,0.06270823,-0.05751074,0.007396372,-0.107216805,0.089280926,-0.10363805,-0.048251554,-0.032569006,-0.002304154,-0.01611829,0.044691455,0.03567175,0.002921788,-0.011953733,-0.045065314,0.018467199,-0.0011405095,-0.027939081,-0.08801754,-0.05761687,0.01286816,-0.025530875,-0.008316369,-0.026080463,-0.065850236,0.020684484,0.081754,0.10454951,-0.07058612 +3.2.2.26,"This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes. ",384,1.0,-0.03775058,0.0026494588,-0.16930574,-0.0099860225,-0.015491303,0.00659877,-0.08321525,0.003884529,0.048785046,0.025894264,0.014329214,-0.044512566,-0.105848804,0.008097738,-0.027483204,0.049277604,-0.10308413,0.034731463,0.0564488,-0.03828547,0.09888693,-0.02417292,0.022090446,-0.09220006,0.005633028,-0.0155653,-0.03390932,0.080435805,-0.0038670872,-0.045276493,0.010022403,-0.0093358345,0.05109739,-0.020451989,0.02835831,0.0924466,-0.08043395,-0.061009865,0.07652845,0.009577681,-0.010372192,-0.03495262,-0.027855882,0.0044810185,0.03897306,0.00318822,0.007673668,0.0017643764,0.07551036,0.027751325,-0.04585517,-0.031120406,-0.06707084,0.0067344294,0.06758719,0.0253002,-0.0054421737,-0.017509263,0.039738316,-0.0037243331,0.04889337,0.011645517,-0.04836425,0.0065588746,0.034828477,-0.06268784,-0.0775082,-0.05339017,0.0108176805,0.022478268,0.06414093,-0.03743871,-0.010665131,0.017533984,-0.011553951,0.056918595,-0.03998107,0.010691955,0.020603139,0.01370027,0.040396616,0.058292124,0.013868418,0.12608662,0.046556573,0.010232127,-0.029816795,-0.04078889,-0.0032956745,0.091519505,0.038973432,-0.0067161517,-0.0037271015,-0.03103012,-0.0019133773,-0.0029297317,0.0072845942,0.06306371,-0.0077509456,-0.041037098,0.025026865,-0.023561321,-0.07703682,-0.1004921,-0.0020930246,0.020096378,0.018484103,0.08039297,0.06225314,-0.011670197,-0.11134691,0.033793665,0.039737955,-0.012660597,0.033539288,0.09915056,0.0374152,0.009360659,-0.021355981,0.029640501,-0.011909967,0.016306752,0.020731999,0.06709386,-0.030936636,0.0051673604,-0.08300292,9.698926e-34,0.05024643,0.06274723,0.00013888441,0.02957956,0.021975597,-0.03595614,-0.006019898,-0.10714052,-0.058997612,-0.007238356,-0.10703596,-0.01937102,-0.03297696,0.0043247226,-0.03538193,-0.04217184,0.007641235,-0.031518463,0.069486104,-0.025647037,0.008419524,-0.0076383846,-0.013446692,-0.124740094,0.030322751,0.033441022,-0.010604788,0.025723604,0.014029957,0.0026642475,-0.06840752,-0.05548493,-0.10758938,-0.027415954,0.013220883,-0.0071687712,-0.03188013,-0.08528267,-0.045356497,0.048124596,0.004158784,0.03433714,-0.06853041,-0.023243017,0.080911905,0.029217798,-0.0460878,0.115017414,0.11493948,0.003369747,0.020210018,0.018919634,0.13005565,-0.03187371,-0.08106225,-0.013797552,0.0053369906,0.0029584232,-0.0014618294,0.10860601,-0.0012284286,-2.1449472e-05,0.019293059,0.080865934,0.0011214485,0.02272986,-0.052671805,-0.03752418,0.0584904,0.096165754,-0.07137561,-0.018721646,0.06529567,-0.030375315,0.06507803,-0.025236983,-0.072468504,-0.055833273,-0.015340322,-0.06514512,0.021641245,-0.09135104,-0.06553932,-0.0030419736,0.011929293,0.018538699,-0.03402642,-0.07606782,-0.03581949,0.03001732,0.038272392,-0.102122106,-0.027208768,0.051883318,0.052825242,-2.6672325e-33,0.007388139,-0.08658741,0.005420073,-0.077759534,-0.06840027,0.039698504,-0.0343213,-0.04692429,0.01970218,0.059324533,0.033487976,-0.07825964,0.099629834,-0.04007674,-0.08574304,-0.0005325041,0.0014430886,0.04585633,0.024147367,-0.011577993,-0.0129988,0.06044811,0.036133993,0.007145092,-0.015351132,0.05385492,-0.0019846621,0.05275872,0.028543161,0.07412961,-0.031672735,0.022667125,-0.08026742,-0.051151086,0.042501826,0.004049686,0.0026146646,0.019807385,0.12610786,0.012347414,0.052369583,0.069675595,0.036344834,0.05626796,0.034901742,0.07911492,-0.061618336,0.07522211,-0.03868596,-0.06237381,0.007643635,0.013654164,-0.07164265,0.046999037,0.036411125,0.038024925,0.01692188,-0.070568435,0.01332259,0.022696396,-0.10985861,-0.066520296,0.023709664,-0.036909327,0.031708784,0.09225185,-0.0077803843,0.059507944,0.028478183,0.03250878,0.09378826,-0.0059779603,0.0049239397,0.06657301,-0.038420558,0.014745099,-0.0056202114,-0.068591595,0.023209447,0.029131973,-0.012121823,-0.013727887,0.022250691,-0.031511486,-0.04147237,-0.10935489,0.057387378,0.083297774,-0.082792,0.074327916,0.0058932235,-0.017810607,-0.06311577,0.04871711,-0.003839748,-2.7937311e-08,-1.2068194e-05,-0.06537227,0.051536333,-0.030886572,0.05003026,0.016246337,-0.086497314,0.042527907,0.0632852,-0.033558976,-0.07428618,0.081625916,0.057612285,0.0096094925,0.015167237,0.07001827,0.048022382,-0.025420649,0.0018189658,-0.08650205,-0.050229948,-7.5520766e-05,-0.06699779,0.034611203,0.008968963,-0.06345238,-0.017141046,0.06187982,0.010158868,0.006426089,-0.032489635,0.05370764,-0.015344456,-0.029019997,-0.06341411,0.06098296,-0.027147168,-0.061909024,-0.0016500445,-0.06804964,0.0047323448,-0.04681141,0.009004256,0.01670333,-0.022166329,-0.010952584,0.02260765,0.056361925,-0.026738135,-0.0009274783,0.047596123,-0.044120494,0.03397077,-0.012600566,-0.0929006,0.017366968,-0.06443649,-0.015724756,-0.013914339,-0.05515887,-0.013646271,0.028051388,0.20038453,-0.09568386 +3.6.1.53,"Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen.",384,0.99999994,-0.017992014,-0.039916392,-0.0074941185,-0.0036253515,0.057170443,-0.048320618,-0.033130832,-0.01450695,-0.053627506,0.053677052,-0.025458809,0.061477803,-0.017897189,0.043172527,0.018802475,0.007588014,0.0007881993,-0.00842262,0.07139236,0.064152576,0.099710315,-0.009738693,-0.010314438,-0.036330726,0.08166502,-0.036652774,0.077792026,-0.032017626,-0.05813283,-0.020493438,-0.04613034,-0.03852533,0.074251086,-0.09613513,0.05162741,0.12349653,-0.019470012,0.015518319,-0.032651246,-0.017721793,0.025484113,0.01827721,0.058095336,-0.057789885,-0.009039601,-0.08305222,-0.00991348,-0.017378747,0.0094899675,0.07205047,-0.027451456,-0.007657867,-0.002810955,0.0022970662,-0.0408586,0.023434222,-0.11491464,0.013112729,-0.055892132,-0.0274322,-0.055881307,0.02247639,-0.05845096,-0.004234651,0.074675195,0.0009122781,0.016777316,-0.0500828,0.024407417,-0.011521177,0.008883853,-0.06272407,-0.013328464,0.029726127,-0.05933028,-0.032779854,0.05986619,-0.08490531,0.092035435,-0.043856896,-0.010286467,-0.0069018626,-0.00010451934,0.042893995,0.038982276,0.058463883,0.006169914,0.07737024,-0.026569024,0.019461742,0.011432517,0.045589928,-0.0070082904,0.0044609285,-0.025012767,0.026079115,-0.025200862,0.095767274,-0.022250008,-0.022543993,0.010398615,0.12572867,-0.040529814,-0.065447204,0.043626644,0.034015,0.0005107033,0.075770296,0.02801054,0.035490423,0.055842128,0.06200299,-0.009699739,0.0257822,0.02640862,0.062998235,-0.047161486,-0.14246367,-0.0025212585,-0.015383576,0.03290236,-0.0015753603,0.013228875,0.08518788,0.041061558,0.10388917,-0.014540637,4.705186e-35,0.01765783,-0.05015251,0.057284612,-0.015117437,-0.055799983,0.0641194,-0.05463688,-0.015192096,0.012271419,0.016010018,-0.12649229,-0.10767861,0.053033497,0.064813256,-0.0051366054,-0.08709333,0.013402496,-0.008486963,0.1523969,0.028180093,-0.030947434,0.083133765,-0.060237974,0.054963198,-0.0004522762,0.028072545,0.0036098291,0.013135587,0.08878203,0.023500308,0.0169357,-0.1023283,-0.062099222,0.016896943,-0.0020737993,-0.00024769493,-0.079463616,-0.040271338,0.010211413,0.068937115,0.02196051,-0.034237232,0.010656044,0.004298896,0.020395154,-0.016624449,-0.037555028,0.0146982735,-0.049636528,0.041788705,0.07996534,0.035156857,0.032421067,0.016628493,-0.07214047,0.014875146,-0.054937646,-0.0071844393,0.08098857,0.09462283,-0.016554063,0.02081281,-0.0069620907,0.058372095,-0.009242243,0.023644915,-0.05113323,-0.13844684,-0.03426114,0.051499613,-0.018857295,-0.10719002,0.059601802,0.005302114,-0.009753798,-0.0369478,0.032499507,0.02518549,0.015016321,0.0011669474,-0.018744685,-0.013931252,-0.040213022,0.02233659,0.02304682,0.03094447,-0.004312797,-0.09394616,0.02125235,0.0009771009,0.027347878,0.016844451,-0.09917405,0.010204316,0.0068687443,-1.875492e-33,0.050670147,-0.061249282,0.06882806,-0.0812452,-0.13800775,0.025816731,0.077999234,-0.10248641,0.060778618,-0.08760448,0.06446893,-0.0012532724,-0.04264636,-0.06566783,-0.0022194874,0.0484452,-0.036669075,0.020240674,0.0349457,-0.0010093325,0.014697441,0.12704225,-0.013200853,0.08352341,0.08189638,-0.030359775,-0.007537214,0.03676273,0.102004655,-0.002445078,0.004962581,0.061294813,-0.026627377,-0.038033236,-0.0065056854,0.05529141,-0.09720491,-0.039201245,-0.005303613,0.063409925,-0.06793755,0.0652523,0.02227696,0.029138148,0.04222723,0.013764416,-0.017298052,0.0036440748,-0.03510999,-0.015400349,-0.019747704,-0.05043349,-0.021749698,-0.02629694,0.016211359,-0.01172047,0.013273532,0.044878807,0.055066746,-0.063535884,0.0165768,0.011163886,0.009872754,-0.016860904,0.006796401,0.079844706,0.039601386,-0.015360571,-0.054600287,0.05638004,-0.0037751484,-0.028336039,0.024617972,0.027277093,0.006707877,0.017054604,-0.064418815,0.05800085,0.0127011435,-0.080516934,0.014222714,0.11301159,-0.018254507,-0.016002867,-0.039817907,-0.06743387,-0.027255168,0.0904343,0.024129571,0.051670443,-0.06301652,-0.08462636,-0.06145318,0.021981534,0.051989865,-4.692943e-08,0.028951107,-0.017211076,0.03054877,-0.093720995,-0.027464306,0.023701461,0.03119334,-0.038759127,0.060870524,-0.05557815,0.0053106616,0.06223036,-0.06864619,-0.0276245,-0.0060639367,-5.6447756e-05,-0.038165238,0.03584385,-0.06125014,0.009844317,-0.03395063,0.0049688835,-0.16669808,0.08843575,-0.010818927,0.016106363,-0.005157464,0.015294199,0.06007932,-0.024215624,-0.0070599252,0.043713775,0.030119251,-0.054952092,-0.00990872,0.04036971,-0.038257416,-0.0030420637,-0.06066176,0.0042177658,-0.06459839,-0.102479465,0.0915575,-0.03816079,-0.042149603,-0.064824425,-0.026986348,0.030220978,0.011305022,0.017108414,0.002718148,-0.022163874,-0.07519278,-0.09978182,-0.034328986,0.007734113,-0.084745854,-0.13281877,-0.037366264,-0.06615769,0.020694654,0.053466816,0.089613765,-0.061914768 +4.1.2.43,"Requires Mg2+ or Mn2+ for maximal activity [1]. The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal [7]. This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase [6]. This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily [5].",384,0.99999994,-0.028632062,-0.07476918,-0.033987798,-0.047258433,0.0820421,0.017755115,-0.07960998,0.0017652909,-0.008662933,0.085546,-0.019660458,0.0054954123,-0.0227423,0.06701378,-0.014311424,0.0016773533,-0.06496441,0.021304877,0.0087706,0.035705898,0.14153649,0.050667807,-0.004240808,-0.02909444,0.05537061,-0.015541976,0.03881322,-0.008561632,-0.08352867,-0.012553533,-0.039197255,-0.044565324,0.10362044,-0.080455914,0.09803936,0.15917905,-0.04250645,-0.020971814,0.006602965,0.0066303588,0.01864843,-0.025479583,0.065046385,-0.08284896,-0.02138026,-0.020927226,0.043911435,0.028522693,0.059039265,-0.011662537,-0.05055472,-0.06486511,-0.01761668,-0.07297681,0.057712775,0.014256402,-0.02747344,-0.021464081,-0.0026424825,-0.0872296,-0.031218477,-0.019487262,-0.028640954,0.0029983022,0.053837873,-0.04153114,0.011069625,-0.055800024,0.023530727,-0.027997848,-0.06666608,-0.03356163,-0.032007027,0.04267792,-0.033087905,0.058462944,-0.0023552547,-0.062366117,0.04896432,-0.024805011,-0.0133511,0.014004137,0.052491937,0.003960178,0.017041933,-0.0005820638,0.023591148,0.05969682,0.045716703,0.012836602,0.075634584,0.057901595,0.022014355,-0.07016483,0.011035426,0.009014504,0.013108937,0.14451835,0.037952922,-0.07390091,0.049071558,0.03640908,-0.036454692,-0.0825963,0.019974928,0.03325268,0.014131319,0.10106066,0.06810917,0.0041944454,-0.042293686,-0.017621607,0.015939578,-0.029956494,0.015394661,0.07177527,0.05497672,-0.07752339,-0.0763019,0.0030472602,0.019341849,-0.052007135,0.11717614,0.051869273,-0.026083585,0.014224235,-0.070982896,4.5182414e-33,0.013904022,0.048639644,-0.035962395,-0.021359634,0.008983255,0.033225186,-0.08103295,0.011267885,-0.03453022,-0.007634891,-0.06631054,0.00722821,0.04815816,-0.013222417,-0.05737293,-0.017886741,-0.01200026,0.02700836,0.04128362,0.06353872,0.025818555,0.045156445,-0.017530367,0.07108771,0.02016163,0.05425784,0.046186063,-0.039603315,0.029746937,-0.028498964,0.039938305,-0.0889611,-0.073789485,0.010148609,-0.005746975,-0.045103703,-0.09642455,0.0022601564,-0.016642166,-0.014480668,-0.013163567,-0.021965178,-0.05146841,0.008095823,0.023650343,-0.039304487,-0.022189088,0.08583163,-0.01168784,0.055598248,0.100875884,0.021906022,0.026518209,-0.006943753,-0.077928916,0.052639782,0.015445837,0.0046638725,0.07962879,0.038145598,0.012331162,0.05508921,0.005005595,0.025505915,0.0030274272,-0.020583453,0.007804588,-0.0518205,0.047998767,0.07350672,-0.029366001,-0.08747291,0.049748592,0.043046772,-0.024335282,-0.0154467905,-0.06439557,-0.024406454,-0.024073834,-0.03769717,0.016973147,0.014669176,0.037821457,-0.014094574,-0.0613336,0.0023785925,-0.040541247,-0.031012379,-0.051517595,0.077132985,0.047384217,-0.109694205,-0.06437046,0.061429188,-0.017537856,-4.4125476e-33,0.16201681,-0.10842601,0.03108541,-0.058470737,-0.08511158,0.046425954,0.035076164,-0.044656713,0.058986492,-0.11602154,0.14435013,-0.007975524,0.03588163,-0.0024645412,-0.02534684,0.010518797,0.01686179,0.1209769,-0.02596126,0.014786797,0.060233217,0.04926791,-0.04401261,0.048974443,0.05362445,0.043893278,0.0046807965,0.007817975,0.052749984,0.04633926,-0.01893215,0.058601312,-0.0032404384,-0.05370746,-0.011716005,0.03427325,-0.057059176,-0.017369816,0.030739723,0.038361832,0.023792312,0.07173174,0.019507037,-0.006345917,-0.011972189,0.05032439,-0.072437726,-0.020247469,-0.02187499,0.01856746,0.023555852,-0.03201291,-0.030174218,0.025351366,0.024836678,0.056614406,0.004306398,0.055881806,-0.052672125,-0.019693762,-0.07415856,-0.05078037,0.080002174,-0.02272634,0.033825945,0.12140855,-0.019907353,6.8136986e-05,0.008102778,-0.00012335458,-0.014577484,0.004779246,0.0226936,0.027090631,-0.0058860313,-0.010362998,-0.019896315,0.012839553,0.06457059,-0.021071497,-0.008994372,0.04458543,-0.0049404735,-0.02665501,-0.013055858,-0.12685029,0.06768872,0.10530954,-0.01248241,-0.0011888098,0.010843092,-0.05788562,0.032307696,-0.0071551623,0.07225444,-4.930859e-08,-0.03563089,-0.017929785,0.05572704,-0.096181326,3.9983097e-05,-0.03377661,0.034483917,-0.049605757,0.05070929,-0.054674916,0.065390795,0.037325103,-0.031384066,-0.06656725,0.0066255718,-0.037607748,-0.14051287,0.008215047,-0.026986623,-0.032880817,-0.03469295,-0.0065541007,-0.13741915,0.06372876,0.016425062,-0.040805183,0.02643366,0.031436414,0.035447236,-0.0059735747,-0.043712787,0.044800706,-0.021501241,-0.08254069,-0.09246065,0.024707466,-0.05725192,-0.022167183,-0.02208516,-0.0039646896,0.0012905524,-0.10390407,-0.018125884,-0.029686466,-0.023291105,-0.016859688,-0.028436387,0.04594967,-0.047703907,0.02335786,0.056533024,0.067834646,-0.028291948,-0.09314859,-0.07339941,0.043824486,0.028703224,-0.1032259,-0.05068201,-0.024316313,0.027873917,-0.06492849,0.15883863,-0.0929114 +5.1.99.5,"This enzyme, along with N-carbamoylase (EC 3.5.1.77 and EC 3.5.1.87) and hydantoinase, forms part of the reaction cascade known as the ""hydantoinase process"", which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids [7]. The enzyme from Pseudomonas sp. (HyuE) has a preference for hydantoins with aliphatic substituents, e.g. D- and L-5-[2-(methylsulfanyl)ethyl]hydantoin, whereas that from Arthrobacter aurescens shows highest activity with arylalkyl substituents, especially 5-benzylhydantoin, at the 5-position [2]. In the enzyme from Sinorhizobium meliloti, Cys76 is responsible for recognition and proton retrieval of D-isomers, while Cys181 is responsible for L-isomer recognition and racemization [6].",384,0.99999994,-0.105319664,-0.07324569,-0.082990065,-0.036409594,0.06530572,0.022701066,-0.07644843,0.06639223,-0.023507861,-0.0010759279,0.009045869,-0.026159815,-0.03143878,0.061504982,-0.009913604,0.05392245,-0.0649054,0.02425412,-0.029720576,-0.057244323,0.03277932,0.016640652,-0.05028899,0.014616439,0.024613181,-0.023742817,0.08125049,0.038010437,-0.036311094,-0.04020542,0.016898055,-0.08310664,0.058620136,-0.093101725,0.014578322,0.064128384,-0.100758195,-0.057581905,0.055492524,-0.0013227427,0.04588392,-0.00596239,-0.013483369,-0.052639224,-0.06579528,0.0032262017,-0.004225198,0.016383957,0.047149923,-0.036906693,-0.04237459,-0.06292445,0.009393787,0.02157817,-0.01961356,0.025888711,-0.07399584,0.006741149,0.0055612903,-0.03286096,-0.008489187,0.045192998,0.054443847,-0.033678908,-0.06657427,-0.01909698,0.018127017,-0.057404973,0.038092606,0.009510437,-0.09037797,-0.00909378,-0.00084882294,0.08495719,-0.028115798,-0.019438643,-0.024978494,-0.073978566,0.004536916,-0.11183348,0.052012287,0.028626578,-0.02567886,0.06956533,-0.016871661,0.005328829,0.001753424,0.06244385,0.06071543,-0.027453301,0.06523691,0.022631472,-0.044764686,-0.10877553,-0.05572776,0.03666112,0.0599371,0.079145886,0.061601073,-0.033912674,0.05926298,0.020902917,-0.068076774,-0.1081554,-0.032937348,-0.009393394,0.0021683748,0.04991195,0.05245025,-0.0039695594,-0.04611759,-0.0037590999,0.018984316,-0.0597705,-0.055030994,0.05942927,0.015741074,0.0045577837,-0.044467628,0.02758394,0.005940944,-0.06955049,0.121223025,0.017047673,0.06282957,0.025592249,-0.16370024,1.8688674e-33,0.04188401,0.032963388,0.002959637,-0.0032165588,-0.012817053,-0.06256516,-0.07322373,0.03042362,-0.015947884,-0.04242798,-0.121290386,0.013566928,0.045112796,-0.020581838,-0.019055637,0.04772238,-0.026207635,0.018398292,-0.024252318,0.07948779,0.056815393,0.055120423,-0.094944164,0.059984084,-0.0047772387,0.035880763,0.09302185,0.012229861,0.023805011,-0.012058226,-0.13174786,-0.098704085,-0.07301032,-0.020982891,0.034862395,0.0020280406,-0.043178726,-0.03900634,-0.011730298,-0.009617168,0.040191285,0.012683685,-0.0038313768,-0.007937257,0.065363236,0.053531818,-0.060578752,0.07078949,-0.022033414,0.10638997,0.061977465,-0.081273355,0.10698259,-0.04548204,-0.06310376,-0.012031802,-0.027330372,0.015287561,0.090224944,0.028938763,0.0044647926,0.0075414153,-0.02257896,0.04271866,-0.014677332,0.00972744,-0.048352428,-0.03285792,0.013829162,0.027786162,-0.047901236,-0.034420747,0.033388622,0.069179535,0.064254746,-0.059768397,-0.017518288,-0.032484762,0.09190678,0.019503977,-0.046059903,0.020834219,0.06602542,-0.02997583,-0.0028689695,-0.020037998,-0.04286325,-0.026830526,-0.035763163,0.044931404,0.059908744,-0.15878819,-0.031754978,0.057192523,-0.007651308,-2.4934035e-33,0.082966134,-0.04771301,0.04254059,-0.045101587,0.0081369,0.085163064,0.06620902,0.052504636,0.029694906,-0.085327186,0.12231903,0.007799393,-0.0056895004,0.03643532,0.03034557,0.016420491,0.020315113,0.06666471,-0.014530718,0.009360195,-0.058325123,0.041298814,-0.017851405,0.028454976,0.050345533,0.043718576,0.013322436,0.07043822,0.010216124,0.10656212,-0.02087365,0.009282015,-0.0818339,0.003055135,0.0021581654,0.054457456,-0.027730504,-0.02834676,-0.004007388,0.01813449,-0.026173532,-0.009883765,0.028543793,0.09485441,-0.05231936,0.07312717,-0.07487407,-0.020031257,-0.009701726,-0.05773165,-0.005147514,0.008659647,-8.792594e-06,0.014195252,-0.032834005,0.057769403,0.042027887,0.08637793,-0.019177109,0.055307068,-0.041204948,-0.07896567,0.030206192,0.04508676,-0.046783324,0.09716112,0.03136249,0.038325172,0.028073454,-0.08652564,0.0906504,-0.009897112,0.07815808,0.060389783,-0.025019562,-0.03172948,0.019202739,-0.029835418,0.003098902,0.015584665,6.390072e-05,-0.03321746,-0.058319386,0.008298394,-0.071784206,-0.03112892,0.03157,0.05488842,-0.028627068,-0.0023018396,0.03879986,0.032522187,-0.041603535,0.065281585,0.06073169,-4.9310987e-08,0.045598112,-0.08391215,0.055675223,-0.05828999,0.013061792,0.053340495,-0.062254507,0.04836003,0.040734194,-0.016269876,0.07640765,0.019872863,-0.059295043,0.056721184,0.012315569,-9.761337e-06,-0.03447648,0.08223552,-0.020424074,0.06612199,-0.0644425,0.00725678,-0.11515819,-0.031399403,-0.0064469855,-0.059835408,0.05192908,0.028442502,0.04171694,-0.066737466,-0.026331281,0.007114052,-0.05271411,0.058060933,-0.02390859,0.03395025,-0.06812869,-0.015237817,-0.02154014,0.020152219,0.04674701,-0.0334224,-0.10964225,-0.0007413907,0.037311766,-0.045538496,-0.05778914,0.023791322,0.015051829,-0.02881602,0.009749363,-0.04365532,0.030077076,-0.10816253,-0.04687144,0.019111425,0.0063745226,-0.06735461,-0.053852476,-0.02403133,0.003331919,0.033832133,0.1417024,0.061378047 +5.3.1.27,"This enzyme, along with EC 4.1.2.43, 3-hexulose-6-phosphate synthase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of EC 4.1.2.43 (3-hexulose-6-phosphate synthase) and this enzyme [4].",384,1.0,-0.015830265,-0.027525516,-0.061284106,-0.05454919,0.058734514,0.03943155,-0.06919396,-0.020847391,0.01224028,0.057822146,0.006174827,-0.035820354,-0.054386526,0.027222836,-0.040044412,0.0011201387,-0.11405468,0.016353898,0.024733925,-0.00017156806,0.061715346,0.07373136,0.01618443,-0.0043110102,0.03194155,-0.031997867,0.04546441,-0.005520383,-0.077205025,-0.017968077,-0.008415126,-0.02406762,0.06560967,-0.1130262,0.10581965,0.14679839,-0.05532358,-0.07728323,0.05380725,0.026788991,0.035315253,-0.025871092,0.0210945,-0.06610341,-0.016070198,0.030533517,0.054617498,0.03480139,0.08728077,-0.06334035,-0.043049388,-0.030155305,-0.023564914,-0.08060229,0.041273683,0.019545035,-0.039865,0.002907811,0.0033972184,-0.05056665,0.048512563,-0.016101008,-0.012149138,0.015431659,0.071271114,-0.072038665,0.051536564,-0.04971592,0.017589936,-0.022624256,-0.1322534,-0.0319677,0.005488532,0.02962101,0.0039036083,0.09542703,-0.049552996,-0.07824179,0.035482217,-0.033995043,0.011593329,-0.022232663,0.0036958696,0.036437754,0.0015931956,-0.041532792,0.03164357,-0.0026998378,0.04733219,0.023215892,0.030171718,0.015323436,0.052252024,-0.09360095,-0.030806944,0.045040168,0.028983232,0.17910723,0.07640565,-0.08034804,0.011466215,0.052773666,-0.028838545,-0.068596154,0.016447173,0.0285921,0.0006851594,0.14392412,0.063359916,0.017382901,-0.043248143,-0.040814195,0.024726773,-0.06994271,-0.03195038,0.11940285,0.04953462,-0.053959128,-0.075754955,0.033415,0.04334847,-0.052116014,0.13040604,0.033050995,-0.03555597,-0.01971299,-0.057737436,2.5861429e-33,0.04436454,0.06851356,-0.012901859,-0.02944717,0.030429782,-0.0014975984,-0.12366773,-0.025519362,-0.049176846,-0.039877497,-0.029759733,-0.011705007,0.05022182,-0.0057483995,-0.082690425,-0.029527618,-0.014869319,0.025375608,-0.0006945103,0.044174366,0.02849048,0.023266666,-0.009080147,0.04063094,0.016772794,0.011044161,0.039757404,0.0042768144,0.023919724,-0.022990067,0.050345123,-0.031503268,-0.07243455,-0.017649272,-0.015697164,-0.084774,-0.05893899,-0.038818616,-0.010437494,-0.026259081,-0.008692634,0.02029916,-0.0015869992,-0.037557654,0.029771168,-0.03853246,-0.031906433,0.13143885,0.028851978,0.04794232,0.047573425,-0.022329068,0.055782516,-0.015142193,-0.027331045,0.012501013,0.028565861,-0.029797811,0.06291883,0.03727247,0.026523815,0.06225929,-0.07004742,0.025365079,-0.016751505,-0.021272015,0.038142864,-0.031864114,0.034125127,0.054087915,-0.040418908,-0.063881435,0.0044708126,0.048324116,-0.019631464,-0.0060627507,-0.10158662,-0.026907725,-0.032080352,-0.057876892,0.0048268116,0.033647563,0.058969967,0.010119611,-0.0036975513,-0.04000205,-0.06791154,0.026113404,-0.009573258,0.08438362,0.04290307,-0.09239884,-0.09929871,0.042553637,-0.02168969,-3.703787e-33,0.15167212,-0.08266051,-0.021552742,-0.03571523,-0.06558853,0.05457459,0.017763766,-0.006668728,0.053958036,-0.059857294,0.12288377,-0.05842788,0.037152197,-0.041412435,0.005335964,-0.014241423,0.030303469,0.075850986,-0.02461039,0.021604339,0.067588545,-0.0038739913,-0.04372065,0.022359679,0.018891564,0.0115853725,-0.004110317,0.03891396,0.026358414,0.08886846,-0.057940535,-0.018071331,-0.0031038478,-0.005366458,0.017879061,0.015587663,-0.024136372,-0.0061129397,0.04774441,0.016153606,0.057319943,0.035116497,-0.018349906,-0.021620082,0.023600807,0.04524524,-0.06559794,0.028791884,-0.021841781,-0.013629309,0.059311476,-0.01897278,0.007121049,-0.016767358,0.0134801045,0.066037565,0.02842688,0.016372977,-0.044512797,-0.026134776,-0.075774945,-0.0643532,0.08690012,-0.006682701,-0.003433273,0.13190782,-0.0553506,0.019794274,0.036979236,-0.027404586,0.02968857,-0.006769433,-0.012866473,0.0017866865,-0.029574832,-0.009459575,-0.036240567,-0.005774096,0.094264895,0.0022932624,-0.008747318,0.024160663,0.023730595,-0.033422492,-0.0032634847,-0.06658965,0.07758286,0.07558524,-0.046005536,0.022933807,0.024106434,-0.028814813,0.026973616,0.03582438,0.054052193,-4.524044e-08,-0.011995234,-0.027833292,0.072220676,-0.04455782,0.012273543,-0.011279163,0.049288552,-0.0260901,0.04436855,-0.049776126,0.04086617,0.055004705,0.023521872,-0.052187715,0.012044035,-0.032301396,-0.14514127,0.025818696,-0.05970484,-0.040779296,-0.03901767,0.00210784,-0.1219956,0.043458983,0.038051337,-0.03346596,0.026531493,0.03676554,0.011623414,-0.05314102,-0.014547042,0.030712908,-0.061218273,-0.07576635,-0.12297399,-0.0237377,-0.056525,-0.035499394,-0.025988963,-0.0012088795,0.017903615,-0.072742775,-0.078632206,-0.01762471,0.016236147,0.03602769,-0.04295971,0.03477459,-0.092768006,-0.011388837,0.08908787,0.08017581,0.004949495,-0.059798293,-0.100242265,0.03687451,0.031247916,-0.077695675,-0.04489727,-0.03797222,0.026373627,-0.039230883,0.16831319,-0.05945107 +2.1.3.10,"Derived from the components MadC and MadD of the anaerobic bacterium Malonomonas rubra, this enzyme is a component of EC 7.2.4.4, biotin-dependent malonate decarboxylase. The carboxy group is transferred from malonate to the cofactor of the biotin protein (MadF) with retention of configuration [2]. Similar to EC 4.1.1.87, malonyl-S-ACP decarboxylase, which forms part of the biotin-independent malonate decarboxylase (EC 4.1.1.88), this enzyme also follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetyl-[acyl-carrier protein] [3].",384,0.99999994,-0.09631234,-0.082855865,-0.049105518,0.009233378,0.01639522,0.10152385,-0.091860436,-0.0009982041,0.009769684,-0.054529388,0.02565124,-0.009562538,-0.13148583,0.030879296,-0.09529595,-0.009929986,-0.0689967,-0.028848266,0.007386433,-0.02112221,0.07495349,0.043796215,-0.06837817,-0.01893759,0.06419551,-0.01803512,0.019316142,0.003244889,-0.046649583,-0.09485683,0.014901076,-0.043258276,0.0632651,-0.008047102,-0.008119826,0.11639611,-0.032994673,-0.070791475,0.11449799,-0.012030691,0.03860966,0.0057549747,-0.037886385,0.013546989,-0.021859195,-0.07115149,-0.012816722,-0.017761357,0.08336639,-0.06608528,-0.06504254,0.04182278,-0.024661088,-0.0006018175,0.00459382,-0.025480594,0.091482766,-0.085879765,-0.04935752,0.005102883,0.074490786,0.029842107,0.0067417016,-0.06904753,-0.04578175,-0.0675047,0.038463734,-0.02530524,0.034880582,0.025455719,-0.081787035,-0.08255415,0.024669813,0.06903883,0.054205693,0.017391121,-0.04531572,-0.035366103,0.00040005616,0.015242027,-7.1428185e-05,-0.018951794,0.0285914,0.043153506,0.009057007,-0.11644818,0.055873718,0.010083689,-0.000756302,0.07767323,0.039440453,0.012331709,0.04901668,-0.07271445,0.03305995,-0.008083354,0.024144378,0.014101231,-0.002093909,-0.036967188,-0.009502152,0.021583544,0.003353423,-0.08578035,-0.023788016,-0.013625363,0.02523165,0.07369427,0.0910206,-0.0013025083,-0.042371593,0.04921251,-0.00732537,-0.016716324,-0.026697803,0.12473661,-0.08414302,-0.06497714,0.0060434937,0.025451986,0.038712725,-0.04012179,0.04085715,0.069422096,0.017710412,0.039623085,-0.1374731,2.095101e-34,0.08547296,-0.015918884,-0.052869346,0.012303227,-0.03888036,-0.040085457,-0.120482124,0.026346918,0.034093335,-0.05907343,-0.020634953,-0.065543205,0.04491239,-0.019476658,-0.06270479,-0.054258943,-0.076927304,-0.06279172,0.071872585,0.0061704596,0.014730426,0.10650881,-0.057392087,0.044620838,0.051368594,0.0019105284,-0.020284796,0.02255034,0.0040588174,0.0013504066,-0.02176073,-0.009374355,-0.047788274,0.0025103362,0.06316818,0.024372635,-0.01031832,-0.03664197,0.041144866,0.07407481,0.172819,0.054454166,0.037305314,-0.0589412,0.045180637,-0.005340018,-0.11308869,0.05665188,0.073635235,0.08558037,-0.0062853955,-0.07114633,0.036287315,-0.020511746,-0.0231626,-0.020517033,-0.111939274,0.04017167,0.059911735,0.0025102233,0.07915064,-0.021934621,0.028206216,-0.02531056,0.012473924,0.056009416,-0.04147527,-0.04913101,-0.0029182322,0.038167384,-0.08029855,-0.011158271,0.05925418,0.035144355,-0.014886971,-0.046601508,-0.098761395,0.051513232,0.02326313,0.018310485,-0.04646483,0.018829178,-0.03813237,-0.06913433,-0.027590035,-0.00039802206,0.0007556962,0.037497707,-0.0017949013,-0.02397389,0.040649675,-0.020179307,0.012909226,0.05607519,-0.0295845,-2.4589123e-33,0.12280321,-0.113046676,0.07538191,-0.0083155325,-0.03901205,0.11009977,0.08392757,0.04764399,-0.056662913,0.022762423,0.07062497,0.017275231,0.10215101,-0.050359774,0.058473732,0.031216396,-0.040723354,-0.028895782,-0.010875397,0.028850144,-0.030597443,0.056172304,0.057843976,0.027877517,0.03203873,0.007975939,-0.05061233,0.08583276,0.043036863,0.0042837188,0.05249077,0.04360223,-0.06973614,-0.033538125,-0.10939381,0.016531965,-0.0387354,-0.006829004,-0.04439981,0.029061636,0.07780385,0.0434609,-0.013040097,0.09579604,0.07225414,0.0002677434,0.004342058,-0.015263328,0.04327345,-0.06522498,0.06232262,0.0018385245,-0.027469149,-0.018330924,-0.035230745,0.112098135,0.035205442,0.037223216,0.010409357,0.039494563,-0.054070458,-0.010106309,0.038351472,-0.07163926,0.006853291,0.05786038,-0.017432736,0.051682062,0.034074888,-0.0392159,0.046682052,0.031749606,0.040097285,0.035403118,-0.0004152557,-0.011542704,-0.07000259,-0.0048042433,-0.04826563,-0.03699293,-0.03679924,0.036757875,-0.05811157,-0.034920346,-0.06152105,-0.026492251,0.029197173,0.03103337,-0.031830773,0.0074113747,-0.012196371,-0.06844535,-0.016557697,0.023233598,0.058093093,-4.180036e-08,0.045424186,-0.009518369,0.049408104,-0.0082037775,0.0016243808,0.05669962,-0.012099751,0.0041198446,0.020015644,-0.04599665,-0.012649544,0.056596957,-0.04982763,0.06867132,0.004271285,0.028335482,-0.107415654,0.07790762,0.020328915,0.0034695626,-0.03249289,-0.035787,-0.09442812,0.056596126,-0.049750246,-0.0062404294,0.018631348,0.039483763,-0.006659989,-0.08152642,-0.018770603,0.05009448,0.023295777,-0.0028565095,-0.07724206,-0.055193957,-0.071019515,-0.077464186,0.003290678,0.06914323,0.05913652,-0.010779961,-0.09304494,-0.007446656,0.02114776,-0.017031334,0.030239778,0.010226881,-0.009218535,-0.0032696023,0.08333482,-0.013829714,-0.038251515,-0.025821146,0.025632177,0.015329858,-0.060994025,-0.06445006,0.01866593,0.02311243,-0.042476814,-0.040613405,0.08511496,-0.05055696 +2.3.1.187,This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 7.2.4.4). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].,384,1.0,-0.03182615,-0.022889122,-0.03245099,0.014838271,-0.013976616,0.009497418,-0.09461149,-0.009406602,-0.0033065332,-0.073384605,0.014372997,-0.016773807,-0.1263506,-0.009030176,-0.047115244,-0.010614693,-0.048986066,0.014005089,0.02961858,-0.023976365,0.07383223,0.041422248,-0.06718944,-0.052059844,0.04122432,0.009508631,0.02389368,0.010788835,0.02045639,-0.09744426,0.022538625,-0.03319504,0.07494218,0.053081933,-0.0026486332,0.10972803,-0.05920271,-0.079378456,0.11375224,-0.050604653,0.049389116,-0.023865309,-0.0027540056,0.0446723,-0.08644986,-0.12232899,-0.092563696,-0.020337217,0.049193867,-0.025739463,-0.021088813,0.04337942,-0.03568044,0.024890862,-0.052971955,-0.030041713,0.053355224,0.03227308,-0.08342029,-0.008007291,0.040318318,0.0471366,-0.04476505,-0.053721502,0.0021733795,-0.012882767,0.030273015,0.007032976,0.045470156,0.009691451,-0.01535961,-0.06785203,0.003651902,0.06547579,0.0049791317,0.0046132104,-0.030104073,-0.035936326,0.006205358,0.07348079,0.0253801,0.028976962,0.07796771,0.050277196,-0.018995155,-0.06353528,0.013062591,0.022520022,0.033638645,0.03895781,0.07063307,0.012221962,-0.01532107,-0.020996585,0.03483976,0.058576163,0.026093133,-0.062197547,-0.023281982,-0.036291543,-0.012680172,0.0079871835,-0.022450952,-0.07095599,-0.06451468,0.01863316,-0.013691516,0.034480948,0.009270636,0.00913298,-0.05260543,0.014997164,0.050573297,-0.004720506,-0.0317771,0.13247082,-0.081276506,-0.034403604,0.0040176553,-0.022256447,0.052138083,-0.0054643885,0.0048680035,0.051642086,-0.03458016,0.0034856477,-0.11966243,2.4612398e-33,0.04538323,0.010902263,-0.0547268,0.009619249,-0.00047809316,-0.06650693,-0.07378489,0.071302116,-0.09172064,0.04240279,-0.003647255,-0.06931742,0.017163241,-0.062251247,-0.003680133,-0.110982455,-0.050873693,0.009192326,0.061681174,0.016834946,0.01336255,0.059391603,-0.044538856,0.053880654,-0.027876537,0.047775075,-0.014783863,0.04979895,0.0268419,0.011714249,0.0016879207,-0.038197428,-0.0060182116,-0.020055361,0.053596444,0.03187421,-0.055633374,0.00029313896,0.02278731,0.101299405,0.16111928,0.0061563877,0.020486072,-0.07161768,0.036669932,-0.033556823,-0.06994919,0.06999169,0.024599325,0.03926624,0.017713435,-0.048502646,-0.03871187,0.025413902,-0.02298416,0.05189282,-0.10206761,-0.0002035387,0.044050217,-0.017759651,0.072911,-0.06392754,0.008646174,-0.008743505,-0.0006906743,0.035823256,-0.053796686,-0.041680057,-0.016987769,0.10649355,-0.0558632,-0.01799407,0.06518253,-0.029998263,0.030778661,-0.015665937,-0.03963582,0.06840484,0.08004367,0.029322848,-0.0015859057,0.06281089,-0.031930525,-0.08195739,-0.007500345,-0.015795456,-0.05738445,0.04599523,-0.045961484,0.0032298751,-0.000101994796,-0.014527007,0.014703398,-0.0006208153,0.012653446,-5.160351e-33,0.13909052,-0.18046841,0.05863888,-0.0695874,-0.034175336,0.06835464,0.0867142,-0.036156055,-0.031464525,0.0771459,0.040237542,0.024899622,0.04977439,-0.08187095,0.050211485,0.092264354,0.012572501,0.031612463,0.013985719,-0.023351423,-0.027759993,0.072108045,0.025775127,0.018963227,-0.018058391,-0.04492016,-0.00909192,0.07348358,0.061465826,0.039391786,0.021002581,-0.013520667,0.00049454044,0.0019714083,-0.09503289,0.080198765,-0.06647114,-0.031836458,-0.035668388,0.040433936,0.026782103,0.019882409,-0.03487305,0.039215375,0.07471036,-0.05196168,-0.041814093,-0.02177586,0.059820637,-0.09560291,0.08000848,0.014031549,-0.020769805,-0.03228999,-0.02772435,0.13779695,0.005865323,-0.021796446,0.052263495,0.0008686177,-0.033325806,-0.019763257,0.014129542,-0.02557807,0.026254456,0.057258446,-0.03313561,0.031061603,0.04531551,-0.03689931,0.044059407,0.015331717,0.030376267,0.040667977,0.019800073,-0.07176993,-0.07700766,0.02782566,-0.06376953,-0.06608325,-0.04396292,0.023427082,-0.049332578,-0.06715279,-0.03165519,-0.030675666,0.028163215,0.096258186,-0.047622867,0.061973542,-0.03924741,-0.041252308,0.031884987,0.060493954,0.094771795,-4.182735e-08,-0.007211794,-0.036100965,-0.022613054,-0.018706333,-0.024997057,0.10053996,-0.010559508,-0.053837527,-0.018488424,-0.043501686,-0.06118751,0.016201755,-0.044897866,0.10310747,0.027640752,0.03478748,-0.08607526,0.06769879,-0.014996704,-0.041540004,-0.009566066,0.025283169,-0.024256568,0.027072314,-0.08072689,0.051583353,0.05343985,0.045077335,-0.013727609,-0.015403586,-0.0534533,0.09242851,-0.032727897,-0.04129806,-0.045563508,-0.023480158,-0.020073181,-0.120417714,-0.012448896,0.06471707,0.051197905,-0.030911932,-0.04391697,0.022744218,0.029028611,-0.0029156387,0.06365395,0.027116122,0.0026491825,0.045339726,0.049777422,0.016252646,-0.097408906,-0.0075712684,0.045899697,0.029479953,-0.07724157,-0.07027613,-0.015630694,-0.029009948,0.0066012265,-0.034246802,0.13227883,-0.11872331 +2.3.1.277,"The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone, as well as 2-alkyl-4-hydroxymethylfuran-3-carboxylate (methylenomycin furan) autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.",384,0.99999994,-0.03349367,-0.021067606,-0.16173814,-0.04484142,-0.008715435,0.051528826,-0.06904732,0.025212336,0.05668248,-0.055507682,0.02984946,-0.048151333,0.011178916,0.007343542,-0.07088332,-0.009750037,-0.082521334,0.026634216,0.04211127,-0.103637874,0.09683177,0.046842266,0.018205924,-0.010240311,0.07353066,-0.03425113,-0.0072861025,-0.025091656,-0.015065384,-0.02454146,0.044804838,-0.081496045,-0.02419516,-0.040119335,0.0819702,0.07560749,-0.022037512,-0.083789654,0.10775689,0.005096573,-0.04527982,-0.030788025,-0.028515905,0.018753752,-0.07841714,-0.01457232,0.06970026,0.03476142,0.04588653,-0.14228992,-0.06176406,0.0012710643,-0.06702767,0.019855715,0.03626483,0.09502641,0.009948782,-0.01665707,-0.023281213,-0.04431595,0.009322985,-0.051703736,0.02323479,-0.039804168,-0.03423716,-0.017292617,-0.012589206,-0.071946956,0.02614687,0.012171267,-0.08909162,-0.018463815,-0.013681046,0.04609246,-0.028272754,0.025404377,-0.04509338,-0.0070721363,-0.010834765,-0.02252913,0.034858897,-0.0050860136,0.07760836,0.11007088,0.007882425,-0.06557992,0.03734541,0.05630268,0.12461641,0.13876504,0.030595744,-0.009668798,0.05317526,-0.020902952,-0.05453977,0.012545091,0.009362276,0.0013055234,0.0601171,-0.022030558,-0.017296823,-0.029362978,0.002654585,0.0042309673,0.011403557,-0.0063181343,-0.01936714,0.08108167,0.061002396,-0.019881327,0.022834154,0.006757759,-0.032495566,0.011240266,-0.016449418,0.09417389,0.08584159,-0.06500902,-0.12387619,0.00140439,0.0047337255,0.013429746,0.0021518893,0.029501526,-0.015969856,0.020858226,-0.092132814,3.4003147e-33,0.03261491,0.09657448,-0.004163283,-0.034475546,0.039831217,0.010968171,-0.11386853,-0.018121006,0.014780005,-0.027014753,-0.053127386,-0.114972815,-0.030999787,-0.0022732096,-0.01777002,-0.09343252,-0.059173185,0.07553522,0.04548736,0.00585071,0.00069696107,0.035568077,0.0034119983,-0.041206423,0.02991256,0.072654456,-0.039587528,0.07464231,0.068713166,-0.013177211,0.01919254,-0.11184852,-0.09474742,-0.006714226,0.09674924,-0.04102331,-0.039736003,-0.07896762,0.07074015,0.06350829,-0.0025247373,0.015278675,-0.028816668,-0.030181997,0.025036132,-0.0107602645,-0.0076149986,0.106299676,0.017736519,0.038084473,0.013492374,-0.02651494,0.12241913,-0.032671973,-0.03173019,0.032537855,-0.05287808,-0.03370343,0.050547414,0.011260781,-0.013837334,-0.027440568,0.027639216,0.017254882,0.02783875,-0.020160282,0.014379043,-0.01569175,0.0057003032,0.060852937,-0.06562287,-0.03392131,0.04840221,-0.03033185,0.044040013,0.0025605296,-0.059168976,-0.023695912,0.043026965,-0.0023093983,-0.07564924,0.03223571,-0.015827628,-0.07609197,0.0086362595,0.10004735,-0.06826583,-0.07651904,0.027120342,0.08973635,-0.027477365,-0.083538644,-0.032864336,0.06670167,0.015055925,-4.254923e-33,0.08432338,-0.08013777,0.023513734,-0.07945448,-0.045118507,0.09272231,-0.0113658365,-0.022843026,0.030704333,-0.03830296,0.027339749,0.018892951,-0.064191304,-0.04392495,-0.010101526,-0.014184369,0.04607424,0.10573727,-0.029606864,0.004380057,0.03883861,0.05969109,-0.05999365,0.032903142,0.010211277,0.01641859,0.001460048,0.035990674,0.06187284,0.06403089,0.07466342,-0.04142107,-0.023163224,-0.07452375,0.0014355719,0.08193982,-0.049873173,0.0613457,0.061137166,0.056323435,0.045283012,0.020676766,0.010988505,0.048000228,-0.009797259,0.03920815,-0.07979627,0.024358451,0.0054680933,-0.052777976,0.006465058,-0.02712942,-0.03133219,0.027021674,-0.005009193,0.006714058,0.046533994,-0.0251379,-0.019682398,-0.0137163745,-0.040419202,-0.094402,0.044764567,-0.016784888,0.03184864,0.023606775,-0.049986504,0.010737891,0.09378184,0.018216584,0.04925194,-0.033569418,-0.03927439,0.06605849,-0.03091612,0.030494682,-0.057456184,-0.058821745,0.036026612,-0.024577353,0.00017612496,0.008130578,-0.0030308792,-0.09197251,-0.068366215,-0.07570796,0.06376359,0.087751806,-0.0031209157,0.0513096,-0.0317012,0.0104054175,0.03341215,0.05780829,0.00048701637,-3.8113615e-08,-0.0013834743,-0.018659012,0.080432974,0.02807192,0.004785347,-0.016554194,0.019534716,-0.005724259,0.059867367,-0.051749583,-0.020799391,0.013853008,0.073266745,-0.014158715,-0.021636007,0.021587398,-0.041201245,0.011239817,-0.002486413,-0.02322364,-0.096202776,-0.0146578755,-0.06902185,0.01328735,0.07941359,-0.076381445,0.045634326,0.07477763,0.023798281,0.058311235,0.050279092,0.017325042,-0.0071310485,0.0017173643,-0.05798539,-0.036686916,-0.06837934,-0.042811126,0.06958574,-0.025377378,0.012552869,-0.039438114,-0.028639581,0.015268116,-0.061992597,0.09934029,-0.07270621,0.030610802,-0.07614502,0.0296876,0.094544984,-0.00036403837,0.010243653,0.012320815,-0.055985548,0.031466763,0.03312975,-0.036261007,-0.048683196,-0.029170979,-0.04040738,0.010039065,0.15939769,-0.106857106 +4.1.1.87,"This enzyme comprises the beta and gamma subunits of EC 4.1.1.88, biotin-independent malonate decarboxylase but is not present in EC 7.2.4.4, biotin-dependent malonate decarboxylase. It follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetylated form of the acyl-carrier-protein subunit of malonate decarboxylase [5]. The carboxy group is lost with retention of configuration [3].",384,1.0,-0.020656765,-0.04821252,-0.00018581632,0.015004012,-0.011536005,0.055667996,-0.074416004,-0.0052832942,0.015385643,-0.09132873,0.052704282,-0.01904269,-0.11041977,0.00028552167,-0.088441856,-0.037712477,-0.047740232,-0.02078251,0.0039076107,-0.07668543,0.027141696,0.024086276,-0.05918313,-0.035051942,0.043437086,-0.027120264,0.017960235,-0.01962187,-0.038388055,-0.107102774,-0.0055972002,-0.06686027,0.029853003,0.051177528,0.015587325,0.10859029,-0.024999501,-0.09956547,0.07691661,-0.010843933,0.042321548,-0.02402497,-0.02127946,0.025425503,-0.031922292,-0.084995806,-0.07647174,-0.034840308,0.051027954,-0.04633773,-0.012051814,0.022182263,-0.008867932,0.041384116,-0.063344315,-0.032125138,0.03002531,-0.038449813,-0.07714291,0.00037333695,0.06171827,0.053069323,-0.0042968895,-0.041129485,-0.035147633,-0.025565764,0.057978537,-0.034793433,0.013192007,0.034593113,-0.047309782,-0.10871516,0.012736594,0.056716613,0.046761166,-0.033662368,-0.050488174,-0.05516641,0.034271173,0.061183244,0.04395484,-0.0005214599,0.02372509,0.009542331,-0.0074386196,-0.085839175,0.025546422,0.010044581,-0.025223782,0.033502877,0.05000238,-0.028214218,0.016667007,-0.020599276,0.003547738,0.025498396,0.008268225,-0.01772502,-0.02062936,-0.044363897,-0.018575056,0.04967521,0.010190221,-0.05940889,-0.06857566,-0.035609398,0.0045372723,0.05361931,0.026623115,-0.008601564,-0.032600038,0.0050706984,0.01545089,0.00023593736,0.008951717,0.14717418,-0.12526701,-0.04945396,0.0034822356,0.02607984,0.050475534,-0.020934029,0.019403407,0.07743013,-0.00093388325,0.036131606,-0.13986671,5.49911e-34,0.03217117,-0.0029582842,-0.03188227,0.01031307,-0.012583626,-0.036410656,-0.0893752,0.089112796,-0.039034493,-0.028808856,-0.034625135,-0.07134548,0.0408093,-0.046076186,-0.019706506,-0.08945149,-0.065564595,-0.027865438,0.054293085,-0.020846428,0.017132606,0.10337195,-0.028673228,0.06959392,0.02176027,0.0140616605,-0.060115054,0.02601529,0.050745297,0.013715031,-0.03399158,-0.036895286,-0.022602065,0.0053902697,0.02957796,0.031254742,-0.0025873522,-0.009170303,0.059983764,0.068285674,0.15516604,0.022095833,0.04113623,-0.08130079,0.046085842,-0.031842977,-0.10661248,0.06319687,0.042397477,0.060504906,0.014614631,-0.046401016,-0.007103859,-0.0031413457,-0.008222541,0.044932522,-0.1281514,0.03292886,0.045518897,-0.040204216,0.07156628,-0.0033214798,0.032178804,-0.056564383,0.006000103,0.06430926,-0.060167912,-0.06202293,-0.030369757,0.08316967,-0.08415869,-0.029088464,0.06829696,0.010828987,0.05345884,-0.038737435,-0.059795417,0.0679237,0.056416262,0.037088763,-0.054626677,0.036064267,-0.038184334,-0.05755851,0.017630609,-0.03730012,-0.01021142,0.06879352,0.027447542,0.031180378,0.03956338,0.018459145,0.0067689917,0.053030845,0.00904192,-3.312682e-33,0.12123985,-0.15247795,0.04861131,-0.022947691,-0.014690409,0.08419496,0.07197123,0.04505414,-0.012193425,0.040556762,0.06580962,0.060316328,0.07817534,-0.09232759,0.041072797,0.047078293,-0.057119478,0.017041635,0.018662944,0.029855302,-0.015296296,0.07192588,0.0631747,0.05427191,0.0061026555,-0.025568992,-0.010143083,0.06473217,0.09506358,-0.008432745,0.009765412,0.012129887,-0.030021515,0.029378092,-0.1258714,0.010447864,-0.038114157,0.025236338,-0.044286314,0.06550772,0.033532076,0.048859518,-0.033543065,0.07551056,0.10418337,0.011727027,0.041928608,-0.0040739095,0.042597767,-0.0753755,0.053502787,0.0022196337,-0.036099084,-0.040396217,-0.025248472,0.15567414,0.027823158,0.013877212,0.027926179,0.011043086,-0.051688727,-0.020229379,0.057786595,-0.03522359,0.044587765,0.032738585,-0.031581823,0.035692755,0.042700227,-0.039591562,0.009857013,0.00036539396,0.011119245,0.00398186,0.026498983,-0.046048034,-0.12056673,0.009090306,-0.04232302,-0.085418135,-0.07367111,0.0486132,-0.015861142,-0.037253115,-0.047262892,-0.028762134,0.030089965,0.07295493,-0.017625228,0.022167936,-0.02682939,-0.034790978,-0.00327059,0.020171188,0.066603065,-3.86147e-08,0.038600087,0.009900059,0.049895793,-0.025901996,0.015007839,0.06734425,-0.025327269,-0.00087313354,0.014851123,-0.064742275,-0.06795566,0.03144527,-0.06530356,0.081675276,-0.019688332,0.016935647,-0.070536844,0.09789411,0.014114301,-0.013339789,-0.023386499,0.003743985,-0.02582637,0.04891686,-0.07969753,0.03563895,0.019622749,0.0718898,-0.033395946,-0.10669453,-0.04490878,0.07778464,0.035327896,-0.03313285,-0.07407712,-0.053787295,-0.03624714,-0.0747035,-0.026179725,0.063025534,0.041494098,-0.034021296,-0.03741741,0.0005064128,0.0006064814,-0.020438245,0.09796856,-0.020331498,0.013856732,0.020993896,0.06462308,-0.025840981,-0.06994222,-0.045295194,0.05726916,0.015599275,-0.077977546,-0.09350725,-0.001111629,-0.034578696,-0.031025687,-0.003094451,0.09711117,-0.07429097 +4.1.1.88,"Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. This enzyme is a cytosolic protein that is biotin-independent. The other type is a biotin-dependent, Na+-translocating enzyme that includes both soluble and membrane-bound components (cf. EC 7.2.4.4, biotin-dependent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. In both enzymes, this is achieved by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-ACP. The ACP subunit of both enzymes differs from that found in fatty-acid biosynthesis by having phosphopantethine attached to a serine side-chain as 2-(5-triphosphoribosyl)-3-dephospho-CoA rather than as phosphopantetheine 4'-phosphate. The individual enzymes involved in carrying out the reaction of this enzyme complex are EC 2.3.1.187 (acetyl-S-ACP:malonate ACP transferase), EC 2.3.1.39 ([acyl-carrier-protein] S-malonyltransferase) and EC 4.1.1.87 (malonyl-S-ACP decarboxylase). The carboxy group is lost with retention of configuration [6]. ",384,1.0,-0.048186723,-0.07962341,-0.019189369,0.02827078,-0.03780077,0.046873342,-0.057481013,0.013861172,0.027153214,-0.07850012,0.045120507,-0.01511715,-0.12132071,0.022937572,-0.053078715,-0.023145325,-0.05886691,0.005846606,-0.011261016,-0.034807082,0.11313857,0.02898237,-0.0886348,-0.04233023,0.03573788,-0.031504605,0.031887524,0.010279286,-0.011296088,-0.08040715,0.0045201243,-0.039476756,0.024209931,0.039276812,-0.009528623,0.10726976,-0.05849447,-0.03380371,0.05730763,-0.06664527,0.039438628,-0.0045319116,-0.00976213,0.0550079,-0.04297823,-0.12909913,-0.12721285,-0.012808659,0.028883666,-0.04477567,-0.050049793,0.03792312,-0.06364211,0.0348917,-0.034312434,-0.00797709,-0.018408416,0.029272519,-0.088176586,-0.024598327,0.009481912,0.025247874,-0.014648429,-0.056924455,0.05008408,0.00078175886,0.048470356,-0.016488846,0.03181359,0.021981804,-0.059675053,-0.100508116,0.040550314,0.06634489,0.045944415,0.032222502,-0.03934544,-0.030317247,-0.06373327,0.053715672,0.060398847,0.025829928,0.02683414,0.054925818,0.024074767,-0.10124363,-0.0006977042,0.028998364,0.012713279,0.032393936,0.04309311,-0.014267374,0.013793189,-0.0252002,0.0315433,0.011687567,0.013638349,-0.056105953,-0.024244761,-0.03251758,-0.0024607864,0.016972564,0.013241929,-0.067022204,-0.031617593,-0.0023429885,-0.016921043,0.026067365,0.0047418247,0.03666487,-0.019548343,0.044155814,0.03871073,-0.00034289958,-0.027019285,0.1285151,-0.11552343,-0.05284861,0.06404317,-0.0034160244,0.011771291,-0.040005986,0.050503872,0.041974876,0.0022639262,0.05166418,-0.15016729,3.4696784e-33,0.0146716,-0.025920017,-0.038616434,0.010777192,0.0063992837,-0.03596935,-0.06766848,0.04949752,-0.047921523,-0.010657072,-0.012112329,-0.027393967,0.044098597,-0.042154327,-0.00016859929,-0.07379193,-0.056605745,-0.0012200043,0.09333621,0.003616943,0.020568518,0.13025591,-0.016128365,0.04045081,0.006651486,-0.009873564,-0.037602976,0.013330531,-0.0169093,-0.002248386,0.0005726897,-0.024404282,-0.014649717,0.0064727133,0.075625874,0.043494564,-0.025224231,-0.012862037,0.028906051,0.055183407,0.11250301,-0.010059955,0.024685211,-0.051420216,0.056836654,-0.07929107,-0.15815747,0.060016297,0.011867003,0.040016264,0.04167433,-0.0459305,-0.014811783,0.018635785,-0.060633447,0.032771707,-0.122581385,0.006627842,0.062149264,-0.007854169,0.045597192,-0.043235965,0.00043150075,-0.032003015,-0.014981778,0.05302484,-0.08755859,-0.08402143,-0.029245373,0.099673726,-0.03100767,-0.03216977,0.05838842,0.043777093,0.014119193,-0.027762821,-0.04450138,0.0699448,0.03806886,0.07334954,-0.0134047745,0.05467137,-0.031964928,-0.029129291,-0.029918438,-0.01896938,-0.05468406,0.041459505,0.016147975,-0.010041141,0.021768508,0.0105653275,-0.014087523,0.009507726,0.033256758,-6.511237e-33,0.1074226,-0.1456741,0.032735024,-0.049781203,-0.005905505,0.08384267,0.09222418,-0.021943204,-0.022655495,-0.016391743,0.02936107,0.043250147,0.05695801,-0.07174815,0.003989288,0.06796449,-0.047353335,0.051955454,0.046141833,0.031264905,-0.03776438,0.11714156,0.024970343,0.0817187,0.006937602,-0.033500172,-0.028541686,0.10413332,0.018610893,0.05424939,0.002033959,0.036579035,-0.049319945,-0.04079874,-0.11268513,0.043826237,-0.105254605,-0.030540586,-0.062068082,0.07894992,0.03312268,0.04438404,-0.01703535,0.04103831,0.09271002,-0.0045239455,0.0034751254,-0.04314544,0.06311908,-0.06906646,0.059629656,0.013639843,-0.018217308,0.00758466,0.026424035,0.117705345,0.015786124,0.009947455,0.00826062,0.02557126,-0.061181203,-0.060630865,0.045304228,-0.07067929,0.05351781,0.03652056,0.0029230372,-0.02177803,0.028723255,-0.04426859,0.027204284,0.025933046,0.01827036,0.00069374446,0.00991956,-0.0671165,-0.107107155,0.018962957,-0.0770755,-0.08773998,-0.043443725,0.039692692,-0.026288364,-0.05077211,-0.050444063,-0.021572545,0.005078829,0.089761145,-0.015790155,0.0492746,0.004784491,-0.054553453,-0.007923865,0.02723785,0.070192754,-5.0436324e-08,0.08227465,-0.009704103,-0.0018556856,-0.03073842,-0.03895541,0.036431283,-0.004957624,-0.04190042,0.0008174952,-0.04086294,-0.061010532,0.043206662,-0.07371998,0.11165505,0.018347222,0.04876121,-0.08118218,0.08575923,-0.028936198,-0.049738936,-0.060356162,0.0046120873,-0.070589006,0.07550839,-0.04360552,0.039925728,0.022658832,0.011640776,0.003770593,-0.030350765,-0.036492597,0.06172974,0.03385438,-0.05242446,-0.045736164,-0.021698464,-0.0010975733,-0.07121118,-0.0026395759,0.07485754,0.039695054,-0.010599197,-0.054134864,0.028810356,0.058828596,0.0023235127,0.06796637,-0.0016282267,0.003120049,0.053592335,0.0602634,0.033849537,-0.064624526,-0.049883343,0.021151248,0.048593897,-0.050404463,-0.061723173,0.04366584,-0.0048324484,1.3754891e-06,-0.025401523,0.13263226,-0.09719749 +4.1.1.89,"Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. The enzyme described here is a biotin-dependent, Na+-translocating enzyme that includes both soluble and membrane-bound components [6]. The other type is a biotin-independent cytosolic protein (cf. EC 4.1.1.88, biotin-independent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. Both enzymes achieve this by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-bound form of the enzyme. The ACP subunit of both enzymes differs from that found in fatty-acid biosynthesis by having phosphopantethine attached to a serine side-chain as 2-(5-triphosphoribosyl)-3-dephospho-CoA rather than as phosphopantetheine 4'-phosphate. In the anaerobic bacterium Malonomonas rubra, the components of the multienzyme complex/enzymes involved in carrying out the reactions of this enzyme are as follows: MadA (EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase), MadB (EC 4.3.99.2, carboxybiotin decarboxylase), MadC/MadD (EC 2.1.3.10, malonyl-S-ACP:biotin-protein carboxyltransferase) and MadH (EC 6.2.1.35, ACP-SH:acetate ligase). Two other components that are involved are MadE, the acyl-carrier protein and MadF, the biotin protein. The carboxy group is lost with retention of configuration [5]. 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The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC 4.1.1.3 (oxaloacetate decarboxylase) and EC 4.1.1.41 (methylmalonyl-CoA decarboxylase) [2]. 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The enzyme uses the energy from hydrolysis of ATP to convert the thiol group of the acyl-carrier-protein-bound 2'-(5-phosphoribosyl)-3'-dephospho-CoA cofactor into its acetyl thioester [2].",384,0.99999994,-0.056386832,0.008183053,-0.081438825,0.018034259,0.0033514844,0.008963133,-0.07549544,0.040042024,-0.025295839,-0.023719044,-0.023283118,-0.083536744,-0.14117366,0.027558928,-0.05278534,-0.039790966,-0.041903578,0.0063804346,0.014032419,-0.0318372,0.12091206,0.07328589,-0.06888339,-0.012389214,0.040720664,-0.011758438,0.0522459,0.032904327,-0.031984422,-0.086357884,-0.019937633,-0.047502875,0.098893374,0.0034168775,0.031865884,0.13658985,-0.04241542,-0.08031162,0.12623513,0.0016648992,0.052267097,0.0057073734,0.018207712,0.023576716,-0.061062593,-0.083333194,-0.005861302,0.019727483,0.11982406,-0.024681544,-0.04712649,-0.006497379,-0.04238702,0.028342785,-0.035796262,-0.02381817,0.04131081,-0.019702679,-0.08345057,-0.020137941,0.0840325,0.04142773,-0.018781975,0.005312333,-0.0033486641,-0.06222418,0.04779821,-0.053619973,0.0056120073,-0.039539747,-0.04024538,-0.08842069,0.006188,0.049999136,0.022575652,0.004606136,-0.041865714,-0.03205549,0.0220737,-0.031140659,0.02304961,-0.02702302,0.023255898,0.06403209,-0.006300488,-0.055504866,0.06646753,0.017155172,0.068992615,0.04156906,0.017214717,0.038016323,0.01902101,-0.07923991,-0.014139176,0.043346524,0.022548506,0.0014157989,-0.018558921,-0.011728328,0.03623035,0.061766844,0.005359516,-0.07969957,-0.04010701,-0.0010450094,0.0087159695,0.0863919,0.04301428,0.027831152,-0.024218086,0.04698941,0.029240018,-0.025104687,-0.017652381,0.11377847,-0.029805819,-0.05202282,-0.009218358,0.033125166,0.055615146,-0.052895945,0.03011626,0.060924023,-0.03202723,-0.007544755,-0.12494835,1.7192308e-33,0.057535063,-0.019234713,-0.015643932,-0.04394426,-0.026913527,-0.019059889,-0.1469825,0.027751494,-0.06419126,0.008869504,-0.05379938,-0.032715544,0.08024796,-0.008226941,-0.021970926,-0.07868322,-0.055486683,0.013850891,0.08277685,0.04090905,0.040310383,0.06260803,-0.08291031,0.051487654,-0.008975895,0.06853504,0.032597084,0.045278337,0.020990232,0.009409698,-0.006901218,-0.07836161,-0.036965907,-0.04640778,0.044825405,-0.044990104,-0.073371105,0.022349302,0.02669505,0.07095991,0.12911794,0.038460474,0.062200274,-0.06017153,0.0278364,-0.041585416,-0.04717675,0.069669314,0.04487175,0.068225816,0.008226026,-0.078641705,0.062405262,0.014575829,-0.0147684915,0.01789711,-0.038837783,0.058932204,0.05544197,-0.0136294495,0.106990546,0.001213483,-0.008873967,0.0017457975,0.021228679,0.026422078,-0.0709041,-0.03469984,0.027343819,0.08243092,-0.127471,-0.007789079,0.06919825,0.015248109,-0.0061176987,-0.032936417,-0.050577227,0.023421474,-0.021114955,0.014380711,-0.022634376,-0.005996829,0.03108717,-0.09316975,-0.037089318,0.02260583,-0.015134965,0.028216166,-0.071128264,-0.0066934926,0.050783023,-0.034748808,-0.033409726,0.031965654,-0.011035693,-3.439482e-33,0.12184639,-0.116263025,0.07924491,-0.08627949,-0.033426628,0.037972346,0.03312962,0.0029760725,-0.042148117,0.041903075,0.0935576,0.0022394988,0.07180319,-0.048558466,0.08341662,0.07732412,-0.0100314515,-0.019878013,-0.008436267,-0.015992459,-0.05777301,0.074724294,0.037504744,-0.0013876075,0.0058319597,-0.01839511,-0.025195645,0.058027744,0.023772959,0.041850556,0.02066977,-0.030099431,-0.04990353,-0.0019084201,-0.10660294,0.039205447,-0.057726562,-0.027232967,0.008992774,0.034113366,0.058431435,0.040708933,-0.02410586,0.034129914,0.053284295,0.00126391,-0.052432284,-0.0050295875,0.0042233453,-0.044482972,0.06886752,-0.01305646,-0.018869253,-0.011470943,0.0064786095,0.07202392,-0.02102206,0.012789028,0.011792239,-0.015355172,-0.052976053,-0.07200932,0.051141173,-0.03342323,0.019291975,0.0768539,-0.06384018,0.04122014,0.015321615,-0.019446913,0.0643353,0.039081782,-0.01001309,0.05827314,0.0010396614,-0.038304843,-0.032041296,0.011322466,-0.053126063,-0.04785589,-0.021014994,-0.0009131865,-0.08587953,-0.07599665,-0.023904812,-0.074522816,0.00054876576,0.08611785,-0.023264464,0.03364758,-0.009464607,-0.045849245,-0.010354628,0.027364457,0.070383854,-4.3042355e-08,0.00863013,-0.03949489,0.025307225,-0.004845986,0.01725014,0.09170895,0.014962993,-0.03865038,0.03872762,-0.015295062,0.023036072,0.03279817,-0.016848158,0.06665788,0.051817264,0.071495175,-0.1153424,0.08370702,-0.00089286314,-0.035452314,0.00065989234,-0.0836023,-0.10543182,0.075171486,-0.025157709,0.012660137,0.027082462,0.0034336473,-0.025016189,-0.039291292,-0.043833595,0.074886926,-0.00092048856,-0.01891179,-0.10578545,-0.017188778,-0.097516425,-0.013405356,-0.03803914,0.09691946,0.07856191,-0.01772017,-0.11597156,0.028209189,0.007718551,-0.0073876106,0.04058286,0.07012876,-0.0059075668,-0.026323073,0.05358003,0.017024232,-0.041953787,-0.004789981,-0.016657593,-0.015745305,-0.07370863,-0.05805769,-0.02699314,0.0070121144,0.05356529,-0.03161492,0.15287217,-0.060580887 +1.14.13.106,"This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.",384,1.0,-0.03413857,-0.025273517,-0.068939656,0.026127797,0.074026704,0.04643176,-0.08863379,-0.00892198,0.05192777,-0.043773986,0.028402448,-0.056299496,-0.002897114,0.036771096,-0.07023359,0.023356711,-0.07666787,-0.030019928,0.012764253,-0.023869721,0.004613162,0.03220836,0.078970626,0.018180829,0.041232493,0.03712776,-0.022925096,0.05174016,-0.0047169235,-0.08128356,0.07965689,-0.020082723,0.089094855,-0.033807162,-0.005010268,0.11712918,-0.027615275,-0.10998539,0.073835,0.053162567,-0.03575671,0.011282843,-0.011877224,0.012853326,-0.044333883,-0.020453207,0.059749782,0.053728577,0.07999927,-0.04882125,0.018287586,-0.048906244,-0.10233271,-0.008578754,0.017843451,0.050011043,0.044491943,-0.06890056,-0.05896513,-0.065533094,0.06601786,0.02655741,-0.0005595675,0.032350168,-0.100906365,0.041899763,0.02312051,-0.08609527,0.023530722,-0.022089273,-0.14993975,-0.058268584,-0.025192427,0.055058017,-0.04885006,0.058553956,0.019305637,-0.03364847,-0.026127385,-0.019875575,-0.0013488301,-0.053777516,-0.042501796,0.102450155,0.055539403,-0.021811118,-0.021848017,-0.03331376,0.07642491,0.01924603,0.042342175,0.055353772,-0.009635033,-0.016443828,-0.061366893,0.061765034,-0.052302208,0.03697065,-0.055053852,-0.013716411,-0.045486547,0.032150462,-0.02844783,-0.068771884,-0.003309962,-0.015092939,-0.015428149,0.039986726,0.036278874,-0.084632084,-0.055531584,-0.059017196,-0.005697274,-0.01656388,0.021510063,0.046566863,0.056827046,-0.08405668,-0.017946864,0.01541389,-0.031281665,-0.012321643,0.001226419,-0.0046867155,-0.02458559,-0.010876582,-0.056092124,3.735476e-33,0.03206419,0.059982475,0.02612173,0.04940932,0.022640798,0.050117638,-0.059893202,0.040362768,-0.05566141,-0.069916554,-0.14523971,-0.03324566,0.048815094,0.022238376,0.06340442,-0.017112892,-0.039285533,0.026408369,0.0735989,-0.0337843,0.0136705,-0.032887623,-0.047643296,-0.067940146,0.0140994415,0.056950007,0.031257153,0.0034588315,0.07948334,-0.015231097,-0.0016889214,-0.025613487,-0.10276113,-0.086840995,0.0026244125,0.0020611058,-0.016799925,0.00468058,-0.037774943,0.07590268,-0.034863744,0.029123452,0.019633107,-0.023608766,0.094148226,-0.067302056,-0.08947573,0.11131271,0.12371618,0.019577038,0.067290835,-0.04316443,0.08011911,0.022007577,-0.07969299,0.09106951,0.0079544345,0.027549207,0.046595693,0.008832109,0.056350876,0.047368634,-0.0022419665,0.01258478,0.057725858,0.07117236,0.029566826,-0.025187626,-0.02752079,0.08186372,-0.06376924,-0.009731138,0.042173218,0.052346833,0.0038005966,0.0032940805,-0.096775055,-0.026229555,0.11705848,0.013766186,-0.08139197,-0.03680307,0.05417184,-0.036309265,0.017349994,0.0070442604,-0.014115841,0.03433753,0.08668733,0.13140346,0.062147815,-0.079811975,-0.008379629,-0.023388108,0.032811224,-3.8484774e-33,0.08926901,-0.11871183,-0.029024804,-0.088325284,-0.050075747,0.0361165,-0.04940846,0.0314185,0.010616088,0.039163515,0.072001144,-0.01915221,0.06328936,-0.05078342,0.029402789,-0.05795349,-0.03547002,0.04178959,0.0053157704,0.051558346,0.1041278,0.010828446,0.04840797,0.02436258,-0.006378844,0.0515222,0.07027459,0.005657079,0.026325906,0.026305817,-0.012510736,-0.03710569,-0.02267924,-0.038935065,-0.03808092,0.065879524,-0.08548936,0.0023759713,0.041517116,0.01708348,-0.004100012,0.05800912,-0.034771174,0.015368294,0.02830946,0.07698879,-0.097201325,-0.03775424,0.012089834,-0.092957035,0.018616872,0.039558694,-0.04503221,0.014384093,0.008601085,0.00066660694,-0.025513273,-0.019629385,0.023612898,-0.05806155,-0.013054886,-0.026935136,0.01289747,-0.027390437,0.061444588,0.049709797,-0.010190526,0.07635774,0.018710727,-0.023322646,-0.00076348643,-0.04936045,0.005309817,0.041281145,-0.025285196,0.051177192,-0.034574628,-0.023322107,0.024362786,0.029453678,0.03596532,-0.026895601,-0.030676143,-0.020749653,-0.09155906,-0.14012635,0.0038536678,0.07574651,0.04049434,0.022957705,-0.017656175,0.034931816,0.011180251,0.030132443,0.09764358,-3.8743455e-08,-0.031340342,0.054450274,0.11537697,0.03537304,-0.012282627,0.007531043,-0.022905363,-0.044715397,0.06048571,-0.10959518,0.025748642,0.009827488,0.061491687,-0.0117334835,0.010891822,-0.0045288946,-0.015147725,-0.015902495,0.039444212,0.01072664,-0.08893787,0.01982383,-0.00035284055,-0.032451287,0.08842045,-0.08132165,0.03060149,0.0059314864,0.0015307214,0.016153863,-0.011247646,-0.005473385,-0.030449541,0.060550954,-0.08055344,0.0031153515,-0.052344862,-0.070822276,-0.034023177,0.03168048,-0.013066282,-0.09245443,-0.093971595,-0.03283339,0.025388513,0.03016834,0.028207041,-0.033353955,-0.050954234,-0.027417142,0.054594032,-0.023768399,0.034838427,-0.0014316814,-0.080881104,0.043540467,-0.041968662,-0.064636625,-0.0657376,-0.06688035,-0.02779185,-0.041796878,0.112993315,0.013120823 +1.14.21.7,"This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product [1,3]. The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation [1].",384,0.99999994,-0.061633248,-0.027918776,-0.08712795,0.01312763,0.07619787,0.042083144,-0.014716545,0.08074282,0.02349291,-0.03201142,0.012479133,-0.06965324,-0.03022457,0.059892572,-0.04688626,0.060995195,-0.073865004,0.02524632,0.013626365,-0.06588897,-0.01678164,0.0014366428,-0.008113995,0.0038772416,0.0076239323,0.011301653,0.009421107,0.02333254,-0.029000577,-0.055863384,0.033139203,0.012948087,0.061101973,-0.04431285,0.047790673,0.092010304,-0.0677672,-0.16666314,0.045595266,0.023893444,-0.032615133,-0.0014211268,0.0010283509,0.0371593,-0.06665653,-0.014630497,0.013496962,0.10151116,0.061428066,-0.070395224,-0.044133034,-0.02022684,-0.0766868,-0.01631586,-0.013674607,0.1055054,0.007041282,-0.034579594,-0.015221507,-0.01299911,0.038296495,0.00021563588,0.024359683,0.04696287,-0.06527874,0.03704108,0.010607305,-0.11200915,0.0440722,-0.0026056804,-0.11145625,-0.08006924,0.0029030992,-0.0034559483,-0.03452806,0.06655876,0.005452607,-0.004777727,-0.028696265,-0.048770417,0.059762638,-0.03697987,-0.035623435,0.10354127,0.07455408,-0.05301223,-0.028703842,0.017708488,0.03136499,0.054796744,0.0054987445,0.068989225,-0.024868123,-0.054034635,-0.15877679,0.06413659,0.025557777,0.018929731,0.0041358406,-0.042443488,-0.008126829,-0.009571049,0.060125187,-0.06767571,-0.010167828,-0.06833739,-0.013503486,0.050468136,0.03807192,-0.029300243,-0.018761775,-0.0034908527,-0.006022235,-0.08881667,-0.0020910117,0.08949108,0.069709174,-0.07053351,-0.044316743,0.04727341,0.027368935,-0.019309763,-0.0087366775,-0.0045403903,-0.012428149,-0.066320255,-0.03460857,3.3107795e-33,0.047267806,0.058307763,-0.042300075,0.021639483,0.026755903,0.023008887,-0.037387904,-0.011205435,-0.121250354,-0.05308442,-0.08212612,0.007891889,0.025705606,0.031186312,-0.0005026519,0.052691102,-0.022907814,0.015803043,0.024690567,0.023573102,0.028207636,0.02608616,-0.023029335,0.018100744,0.031214358,0.05380587,-0.0055715577,0.0078992965,0.029516492,-0.008922731,0.026390178,-0.04123605,-0.083980896,-0.007145309,0.0071802954,-0.012147041,-0.09004831,-0.07363834,-0.032845255,0.110879086,-0.09520627,0.052506734,0.056762666,-0.016563455,0.08844244,-0.021142809,-0.070729405,0.07704444,0.040129077,0.061762672,0.02387556,-0.046629,0.07508329,0.024275523,-0.06771143,0.044778246,0.019580552,0.031353645,-0.01755496,0.020765759,0.042988636,0.080063,-0.02000572,0.04807841,0.03284573,0.014818585,0.038624834,0.028723838,0.021784011,0.078987904,-0.05455184,0.0059163584,0.039841544,-0.022761595,0.013036697,0.009921215,-0.057457197,-0.04360845,0.06628399,0.033310946,-0.05716532,-0.013293053,0.0164222,-0.08111204,-0.03719028,0.03376716,-0.018904941,0.06480618,-0.020665415,0.076286815,0.05253722,-0.11246959,0.0045122216,-0.03750888,-0.02273241,-3.4074077e-33,0.08934791,-0.077177085,0.00893769,-0.07263774,-0.0741326,0.0137778,-0.07272892,-0.0035714263,-0.032444328,0.008342979,0.115214236,0.010270193,0.0038462165,-0.025348691,-0.016981592,-0.021742497,0.025724096,0.08296432,-0.035329144,0.016272916,-0.0005365594,0.0235647,0.060428243,0.007906635,-0.059514202,0.042197086,0.051775597,-0.036849406,0.06414562,0.05162696,-0.05888355,0.018555377,-0.03455078,-0.060802996,0.055141497,0.018435843,-0.020109199,0.0020651517,0.05546635,-0.009240553,0.06400729,0.022542017,-0.03401534,0.011219692,0.021126946,0.07819937,-0.09569446,-0.04066407,0.019155227,-0.04460673,-0.012910947,0.01837666,-0.07635003,0.0065722107,-0.0415648,0.0024327931,0.046495073,0.009949488,0.0012388916,-0.0034696013,-0.020396424,-0.045757364,0.048396036,0.017900154,0.058826327,0.13099018,-0.029311312,0.14428906,0.042477235,-0.032179378,0.027724177,-0.007136723,0.025199752,0.119548485,-0.033369858,0.015787132,0.0009294273,0.02183666,0.026475927,0.0284762,0.046865482,-0.044103324,-0.012815626,-0.032762833,0.01674897,-0.17481685,-0.060337868,0.02299642,0.034302663,-0.03545494,0.001506229,0.06205461,-0.003948769,0.0051176827,0.074265756,-4.157734e-08,-0.0067638564,0.006575108,0.062166456,0.007532081,0.08314601,0.03769116,0.013585433,-0.037472032,0.026726674,-0.02269237,-0.06778552,0.06269414,0.016211996,0.012922383,0.02487956,0.0829089,-0.08319496,-0.081530474,0.02626161,-0.000532413,-0.11614275,-0.009004927,-0.087349,0.0448423,0.014330543,-0.009798133,0.016208766,0.023627313,0.051479757,0.046028726,0.014543392,0.027694939,-0.05823248,0.06947201,-0.071098335,-0.052959833,-0.03798701,-0.08342163,-0.058440562,0.03152411,-0.050715163,-0.013098011,-0.09531042,0.0043862457,0.01595196,-0.0021481838,0.015487992,-0.0066141156,-0.0398604,0.013962924,0.05920637,-0.05974736,0.005244257,0.00809388,-0.116918966,-0.048668817,0.09575832,-0.04460317,-0.03944779,-0.06724887,-0.04370888,-0.04525331,0.16699506,0.0024789204 +4.2.3.37,"Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.15.39, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2].",384,1.0,-0.09077975,-0.06175253,-0.030203342,-8.205835e-05,0.0299974,-0.022256795,-0.040351238,0.04379291,0.06675316,-0.05128809,0.0043202424,-0.037641495,0.047569435,-0.00035561895,-0.03282613,-0.02731056,-0.008152374,0.02593702,0.06749354,-0.0071215974,0.07010396,0.0842453,0.027758872,0.0007386128,0.025571203,0.055518363,0.005565315,0.001979171,0.041103296,-0.07331711,0.06216003,0.039933782,0.08338746,-0.121127754,0.041085795,0.14798789,-0.042675603,-0.06843587,0.054858655,0.063436106,-0.0011732158,-0.017107781,0.08380256,0.0052909334,-0.04363045,-0.049327135,0.113026544,0.010351862,0.07370671,0.0045100837,0.0016322039,-0.06642113,-0.098899186,0.029489255,0.03663998,-0.04051301,-0.028923726,-0.013796616,-0.06142038,-0.0679683,0.06550242,0.00069532334,0.0038685384,-0.014075961,-0.024258824,-0.009413459,0.035099525,-0.10342674,0.067513615,-0.019502107,-0.13025187,-0.01368021,-0.043931797,0.038404915,-0.06708391,0.066034414,0.040909156,-0.016618874,0.017459853,-0.037821986,0.033225413,-0.06672439,0.022815872,0.08680529,0.029277535,-0.03419167,0.00551256,-0.0049021654,0.08051603,0.048238173,0.10207975,0.058773465,-0.014676713,-0.022500113,-0.08824151,0.02700387,-0.067466676,0.034774452,-0.04671428,0.012314865,-0.028945837,0.073698886,-0.05198863,-0.018795995,-0.009898831,-0.015593299,-0.09740368,-0.0022040487,0.037351973,-0.017003994,0.0014192993,-0.020465665,0.014194,0.028339488,0.0060354737,0.029656038,0.05322598,-0.11800465,-0.027763547,0.021063223,-0.026351478,-0.014045938,-0.012449156,0.027589267,0.0031353936,-0.0029017716,-0.058112014,2.9029553e-33,-0.009349236,0.04098656,0.057478573,0.018913394,-0.075791106,-8.19833e-05,-0.06218996,0.047947656,-0.025811393,-0.03527849,-0.08680098,-0.06179229,0.059675444,0.056767963,0.027282797,-0.030643927,-0.0032807929,0.032964054,0.122544885,-0.0574773,-0.020228632,0.017408656,-0.037703022,-0.01023729,0.05014389,0.07140856,0.0140479095,-0.011837374,0.08175656,-0.026321173,0.09732039,-0.07035797,-0.08735068,-0.049980335,0.04760531,-0.060288567,-0.026170632,-0.025552744,-0.02980215,0.02623823,-0.05646462,0.032850303,-0.027411139,0.015344642,0.10766068,-0.14928567,-0.029745094,0.07076508,0.07492295,0.063823834,0.07311341,-0.0223526,0.08726214,0.01728042,-0.085905015,0.06211885,-0.036374267,0.023555586,0.08093616,0.032943115,0.0006001819,0.010991399,-0.011246123,0.037194956,0.10147329,0.059902694,-0.012740247,-0.023444297,-0.01911787,0.119184434,-0.016594643,-0.06882074,0.020243833,0.047414403,-0.056710627,0.00015794265,-0.108051986,-0.009509822,0.07774659,0.03317314,0.0031726887,-0.044486027,0.0026346568,-0.059528857,-0.07084973,0.04700292,0.025862245,-0.050469175,0.07394779,0.09867593,0.055194803,-0.093583696,-0.05837457,-0.014467719,0.05032494,-2.972918e-33,0.11671257,-0.068137325,-0.037850413,-0.076768644,-0.057286736,0.0369617,0.02660398,-0.005103179,0.0018644589,0.02632985,0.067941725,0.014612914,0.04004142,-0.062785976,-0.01797726,-0.027678702,-0.026675714,0.03574691,-0.029565932,0.028406266,0.08446446,0.054011427,0.06019553,0.048123483,-0.008749597,0.0007912554,0.036103807,-0.0025203347,-0.04240719,0.09816618,0.004437524,0.0021693832,-0.041133456,-0.043106765,-0.06996257,0.04493726,-0.075365566,0.028558135,0.04701834,0.027667914,0.028559353,0.04965517,0.048182573,0.06245624,0.037919514,0.04808772,-0.10024523,0.008831194,0.042397905,-0.0958909,-0.056795157,0.024830416,-0.030570202,-0.027738914,0.046463218,-0.012365731,-0.07393075,-0.051145107,0.0031457506,-0.063105434,0.007926487,-0.03417171,0.011535247,-0.10608297,0.08436313,0.07742903,-0.010989588,0.03909127,0.034137618,0.012437364,0.026103923,-0.0028352742,0.06574385,-0.0018166247,-0.019859325,0.07048177,0.0038390106,0.013599316,-0.010436808,-0.02887925,0.019857166,0.004261542,-0.008725117,-0.0534943,-0.06329005,-0.12846832,0.0041414993,0.07213431,0.028722545,-0.00025895718,-0.049821064,-0.023991752,0.029086363,0.035152275,0.08658209,-4.2376385e-08,-0.029422604,-0.0055203727,0.10988135,0.01617452,-0.010579904,0.03058108,-0.023461524,-0.038713682,0.036883485,-0.015631676,0.015582035,-0.017774858,0.039553907,-0.004918611,0.057824988,-0.004742202,-0.03680252,-0.002970049,-0.04476436,-0.07663663,-0.039401077,-0.028959587,-0.020650452,0.035205115,0.0738564,-0.05168392,-0.012471954,-0.034040272,-0.0399414,0.0013611915,0.04168428,-0.018619273,0.0018849104,0.024590716,-0.06213448,0.015771203,-0.05607589,0.01279936,-0.016770598,0.016473435,-0.066798605,-0.032703266,-0.07790011,-0.0113026155,-0.03968803,0.0671915,0.004164235,0.032806974,-0.09577905,-0.014258849,0.0769728,-0.049050014,-0.03503423,0.038936283,-0.040291026,0.006759935,-0.047782205,-0.051011413,-0.06089756,-0.06952884,-0.031212542,-0.007817954,0.066223085,-0.047490127 +1.3.1.83,This enzyme also acts on geranylgeranyl-chlorophyll a. The reaction occurs in three steps. Which order the three double bonds are reduced is not known.,384,1.0,-0.048779603,0.031204278,-0.09089643,-0.038718734,0.013854574,0.037442755,-0.080230676,-0.029319718,0.07989568,-0.0002730239,0.09753624,-0.0355878,-0.038361717,0.07096864,-0.0001674581,0.0674137,-0.1650638,0.016098334,-0.054451514,-0.056606527,0.09305325,-0.028528972,0.0024348618,-0.016700733,0.08324806,-0.015095057,0.0734311,-0.0071896138,0.016469479,-0.06763009,-0.0056703542,-0.0042903,0.024699474,-0.0073737437,0.04256153,0.05371134,-0.04416547,-0.08801554,0.008844868,0.055576336,0.033292055,0.009087189,-0.050864715,-0.040676292,-0.06662716,0.023880543,-0.029189363,0.008018195,0.026920758,-0.053202894,-0.03865201,-0.04969944,-0.046800517,-0.021814393,-0.011492123,-0.0030529646,-0.043594494,0.002780451,-0.031619977,0.022896493,0.05856384,0.003297973,-0.064942375,0.019947248,-0.0009634168,-0.03449052,0.06286798,-0.08858245,0.021434013,-0.038475312,-0.07344743,-0.07627186,-0.0073767677,-0.05000633,0.007563025,-0.07115795,-0.03039471,-0.026455173,-0.009101638,-0.03296669,0.0059014284,-0.0341894,-0.01335784,0.04732816,0.048333634,-0.0036794376,-0.053375043,-0.0067792498,0.037343867,0.061334137,0.012075607,-0.009461221,-0.047813863,-0.041594636,-0.07601474,0.13168994,0.027669968,-0.072035715,-0.03241354,0.01078329,0.037906308,-0.0034848733,-0.062346157,-0.08503333,-0.044059217,0.051132936,-0.00087987375,0.07945515,-0.03318877,0.010311438,-0.013794019,0.0007198462,0.07781431,0.029681243,-0.03661374,0.13608989,0.06331542,-0.024742244,-0.057136368,-0.002379342,0.03193115,-0.045637656,0.030081037,0.027728284,-0.09397202,0.0636909,-0.08076587,2.2895833e-33,0.051341593,0.0320007,0.005884197,-0.044734012,-0.0025970808,0.013465759,-0.053159665,0.041692868,-0.08321812,-0.07677519,-0.0073363087,-0.11984847,0.020137018,-0.0070834,-0.11318745,-0.027116088,0.04839414,0.033274226,0.025003703,-0.0063298587,0.029195458,0.09638978,-0.038298644,0.005943827,0.032042712,0.0053554676,0.008033618,0.0032076298,0.072193,0.0024167697,0.04822798,-0.053332623,-0.13093725,0.026589103,0.049622506,0.03289402,-0.027453916,-0.008068608,-0.0051002037,0.043974042,-0.054396026,0.012429493,-0.017937846,-0.007746723,0.06948209,-0.013632192,-0.02631571,0.09209391,0.0909575,0.09278582,0.028705895,-0.012963271,0.060836267,0.005651026,-0.06955507,0.07328743,-0.003202585,-0.017414952,-0.014752712,0.033287894,0.006841358,0.030918155,-0.044258256,-0.015989969,0.05300079,0.03456628,-0.07448347,-0.07923102,-0.023141414,0.059259206,-0.092743605,-0.013485957,0.0790054,0.08962804,0.080633014,-0.026781097,-0.031486332,-0.041021362,0.016188635,0.015507451,-0.07453526,0.0111682145,0.083529636,-0.054506272,-0.05876386,-0.025349583,-0.026563186,-0.078131296,-0.020779891,0.031100597,0.06822906,-0.018156156,0.010472389,0.040638328,0.064332716,-3.827261e-33,0.1204575,-0.08325125,0.041228633,-0.08516139,-0.036204137,0.017785538,-0.047774058,-0.06794804,-0.055163484,0.013699484,0.106224455,-0.013426821,-0.043829124,0.022330439,0.03295144,0.020692928,0.101699874,0.08746405,-0.012620433,0.039599024,-0.018547151,0.06577866,0.045698207,0.02309153,0.023023384,-0.002614693,0.014882281,0.03464365,0.055720925,0.06675669,-0.034772974,-0.04048839,-0.03128675,0.01913356,-0.011319581,0.015556237,-0.030168848,0.005496312,-6.406601e-05,0.021800099,-0.00074228575,-0.0057753692,-0.0065866965,0.06796476,0.050371394,0.057699244,-0.0474405,0.020578552,-0.03311561,-0.09435212,-0.059402674,0.06666366,-0.013348467,0.005663247,0.060348805,0.06494265,0.08035894,-0.05319663,-0.009804158,-0.061732486,-0.049438126,-0.014993784,0.04406306,-0.03568018,0.055883203,0.069926515,-0.0015431005,0.1100228,0.06946202,-0.0817305,0.041331828,0.07457029,0.026286475,-0.0038506046,-0.047257032,-0.063499406,-0.032070618,-0.08434664,-0.014287578,-0.06540872,0.017041568,0.00010592867,-0.041482486,-0.08270275,-0.086648405,-0.10653253,0.040457197,0.09625925,-0.0026252866,0.0052203806,0.007863606,0.10985491,0.030758396,0.08268934,0.09644755,-2.7527927e-08,-0.022489227,-0.06917308,0.03020552,-0.06204303,-0.013078491,0.06587311,-0.04365172,0.013902138,0.051287763,-0.0700978,-0.06354148,0.100789376,0.014913235,0.03531428,0.014464666,-0.020096809,-0.041890834,-0.023419306,-0.027026607,-0.082919575,-0.07146308,-0.027322564,-0.10703793,0.056410685,0.0122501105,-0.03339802,0.024535568,0.09377392,-0.011783234,-0.012986823,-0.0009677871,0.013710591,-0.034107894,0.028695881,-0.03201762,0.008657232,0.0010094766,-0.020898364,-0.00425115,0.029322054,0.0431588,0.004570678,-0.06005812,0.055203196,0.05500524,0.018483607,0.0051450315,-0.04411821,0.0077610356,0.024975723,0.0573317,-0.023600362,0.021493211,0.02642407,-0.0891523,0.0021968635,-0.008876403,-0.060101412,-0.022066224,-0.028250474,0.032171417,-0.00657306,0.10546147,0.055323653 +4.2.3.43,A multifunctional enzyme with EC 2.5.1.29 farnesyltranstransferase activity.,384,1.0,-0.034273755,-0.033581793,-0.060998213,-0.0071136276,0.084439866,0.020562813,-0.11055671,0.004924701,0.0826224,-0.011331553,0.019613061,-0.06571719,-0.058927223,0.021903219,0.003095292,0.027977496,-0.13079381,0.065547355,-0.012766869,-0.023650939,0.029461272,-0.0035547323,0.043689467,0.00048625757,0.018466825,0.020573957,0.02691969,-0.07778409,-0.040412124,-0.10025724,0.048488077,-0.078443095,-0.012973584,-0.039870773,-0.00875941,0.08039385,-0.01563497,-0.106786095,0.004088484,0.032799326,0.039507043,-0.050554667,0.0012886347,-0.030950498,0.008963997,-0.024939012,-0.00047283334,-0.009176032,0.015491931,0.0034292897,-0.011724221,-0.076211296,-0.027117927,-0.059435025,-0.0059368014,0.027806392,-0.04684887,-0.002263358,0.007588918,0.060384627,0.10607744,-0.0023780002,0.046978768,-0.0483356,-0.013877313,-0.040314134,0.0680795,-0.0913272,0.060155265,-0.07663571,-0.16665171,-0.07589666,-0.017059967,0.01925887,0.0517813,-0.0507505,-0.052835397,0.03967881,0.06500649,-0.052047662,0.05002797,-0.079809174,0.0104418695,-0.012357161,0.020712886,0.033083882,-0.025905449,0.0453651,0.05316499,0.06746947,-0.01818076,-0.06635925,0.03190974,-0.009269435,0.015273871,-0.0023641204,0.025646681,0.08400047,-0.021979013,-0.065214306,0.03614389,0.05405919,0.01571547,-0.06568203,-0.016463816,-0.033448435,-0.029497353,0.049529873,-0.022194937,-0.094976105,0.036600422,0.039974995,0.10612226,0.0138770165,-0.037142582,0.08136907,-0.01638465,-0.055593207,0.01427838,0.04691899,-0.021336416,-0.01116076,0.044620946,0.1075111,-0.03728424,-0.0143651,-0.058746167,-5.8841243e-34,-0.001036171,0.07289544,-0.021014936,0.026315777,-0.058711983,-0.0042789923,-0.07676099,0.059647076,-0.057713035,0.02139555,-0.03200535,-0.018143885,0.069382116,-0.008795838,0.09015957,0.0029122836,0.029175892,-0.015999958,0.05588589,-0.11739401,0.016260287,0.040139206,0.0009442942,0.01874926,0.05116391,0.06790108,-0.028424656,0.045203518,0.09773685,-0.012533779,-0.024895169,-0.09029449,0.005320513,0.01759362,0.046844706,-0.008037366,-0.06937808,-0.050929416,0.020100508,0.0038216342,0.001873397,-0.018014846,-0.03633173,-0.022530042,0.030831384,-0.025268553,-0.01389816,0.12885886,0.090941325,0.01689982,-0.04141268,-0.06721817,0.032108564,-0.0004614454,-0.080363356,0.0021255426,-0.033494055,0.0047254413,0.034415595,0.027904678,-0.028803628,0.08024941,-0.0029689698,0.0060220924,-0.00096129975,0.0021812143,-0.040917393,0.010495068,-0.036977716,0.14630812,-0.003938616,0.004441518,0.12185091,-0.05462257,0.06737699,-0.02825583,-0.08264007,-0.042567283,0.052072458,0.054815743,0.022212928,0.0029630307,0.0045563704,0.0073260744,-0.014391803,0.013655863,-0.047915597,-0.016194826,-0.01152914,0.18969269,0.016777774,-0.10251083,-0.019020993,0.037109245,0.013966259,-6.5691616e-34,0.09080747,-0.045994565,-0.030270632,-0.043812905,0.006670738,0.03297632,-0.009920703,0.01811867,-0.0041265977,0.023239756,0.122688346,0.0042063533,0.03997019,-0.10514974,0.05917274,-0.026086131,0.032257076,0.023616185,0.003501391,0.038322423,0.0086459555,-0.002714835,-0.055018894,0.06728929,0.0016917994,0.05202688,0.0024371126,0.04552141,0.017490366,0.035977136,-0.043560732,-0.017559648,-0.039104193,-0.0374216,-0.0346122,-0.010329558,-0.058948223,0.05749595,0.013999839,-0.029365834,-0.045964718,0.008532549,-0.037699766,0.046985365,0.05611389,0.13172744,-0.030842496,-0.025694616,-0.04244808,-0.086824104,-0.00061424234,0.032425568,-0.06164684,-0.012230954,-0.062665984,0.04961612,0.0009237099,0.011838758,0.037191253,-0.07301074,-0.08631464,-0.06633831,0.08158389,-0.04696415,0.036354393,0.027481101,-0.0352386,0.103033684,0.057665173,0.024501046,0.053927537,0.017723367,0.041314438,0.029741436,-0.057310767,-0.004127415,-0.039541736,-0.06144528,0.06100996,-0.03364366,0.03384624,-0.028164446,0.046148956,-0.09328284,0.010424963,-0.08105855,0.012389384,0.12925914,0.031753685,0.062294897,-0.002743587,0.017414631,-0.044487443,-0.0076135113,0.066191174,-2.415008e-08,0.027399153,-0.056113265,0.011141714,-0.030524606,0.028673869,0.06292429,-0.0049973847,0.107112445,-0.046047878,-0.007205465,-0.046137277,0.00087991945,0.029977715,-0.0047730054,0.04775459,0.018860998,-0.05292323,0.046237137,0.01622258,-0.0292177,-0.030983424,-0.001314263,-0.079137675,-0.011490946,0.0051490082,-0.04234668,0.033153195,0.07502805,-0.039731767,-0.09178967,0.06515432,-0.05229771,-0.013721573,0.039103884,-0.098516,-0.009973042,0.047525026,-0.036334995,-0.030062303,0.054076355,-0.005157725,-0.0041285194,-0.115086235,0.10625533,-0.05108532,0.014808619,0.044296548,-0.013190207,-0.016804427,-0.014525679,0.06324506,-0.030269315,-0.020383518,-0.03232089,-0.060233895,-0.0066625075,-0.021207996,-0.08054756,-0.05750585,-0.032544445,0.039739404,0.00402931,0.11148831,-0.060913417 +4.2.3.41,Requires Mg2+ or less efficiently Mn2+. The enzyme is also able to use farnesyl diphosphate and geranyl diphosphate.,384,1.0,-0.05916591,-0.0679337,-0.02445666,-0.006568035,0.0359356,-0.06448423,-0.047880135,0.048300374,-0.036804818,-0.008189493,0.011855598,-0.00040712868,0.0014424414,0.035161562,0.035539627,0.046608042,0.0062277657,0.034763794,0.03694494,-0.0008210049,0.12879808,-0.011402824,-0.0034414567,-0.054754123,0.05842084,0.02063606,0.065975,-0.057966966,0.056413554,-0.01084521,-0.021900116,0.0127046425,0.04124937,-0.08352216,0.011742695,0.1398114,-0.055716008,-0.024634458,-0.030964822,-0.01643814,0.038085457,0.034984436,0.117622815,-0.04236845,-0.017863361,-0.086941324,0.0746298,-0.033749413,0.03220763,0.06293194,-0.08121265,-0.04822383,-0.035350103,-0.03768499,0.0033814334,-0.023475166,-0.13612366,0.007294169,-0.056649294,0.012885836,0.0014670976,-0.010885942,-0.052457497,-0.051345024,0.06984812,-0.02654069,0.022598196,-0.04241346,0.038112894,-0.020795466,-0.013362408,-0.026611852,-0.031020619,0.037096225,-0.0538865,0.0050753034,0.061315805,-0.025588999,0.0832864,0.0014655169,-0.03054085,0.0014454359,0.048512552,0.05756329,0.08739984,0.097912684,0.023863299,0.070953324,0.010070237,0.0533984,0.08513766,0.04648385,-0.050805926,-0.0014384405,-0.0014843734,0.02414567,-0.03716781,0.06184533,-0.04475749,-0.011770438,0.051713355,0.053005714,-0.027710294,-0.007954655,-0.027804269,-0.009101366,0.0019131706,0.04306563,-0.009243203,0.0065904493,0.079344705,0.058625743,0.051101323,0.042003687,-0.008890666,0.06138359,0.0063069975,-0.1313994,-0.031791642,0.041543636,0.0032729714,0.0024156945,-0.03376051,0.06490142,-0.046283763,0.0630377,-0.06941198,3.3809124e-33,-0.0073160557,0.052314382,0.02537202,-0.03776254,-0.085276216,0.05862114,-0.06595841,0.004291442,-0.032711387,-0.02127189,-0.06958048,-0.099396124,0.042611636,0.022907557,-0.017242337,-0.088988446,0.04298471,-0.0051876977,0.13373949,-0.007583382,0.010088862,0.03157028,-0.021869954,0.0062379995,-0.0108204065,0.11709522,0.06557564,-0.023335788,0.08186633,-0.0070808097,0.053788316,-0.15040489,-0.033939898,0.023091841,0.03962615,-0.02479599,-0.05658894,-0.05442872,-0.03336043,-0.011124328,-0.024845866,0.031089146,-0.07935644,0.049549118,0.051080313,-0.10444977,-0.028834587,0.07596857,0.0019312599,0.04933664,0.07455316,0.03677326,0.017227065,0.0075877635,-0.081786446,0.037860144,0.00014644279,0.010296152,0.06606769,0.03177174,-0.043892868,-0.00096296804,0.029831821,0.081806526,0.08209433,0.03088802,-0.07068484,-0.05974529,-0.036594328,0.11464725,0.002640449,-0.09472124,0.045258697,0.012645628,-0.022128467,-0.046616305,-0.024319204,-0.00504623,0.05096668,0.020963171,0.008522385,-0.02587607,-0.0032462282,-0.012272098,-0.089475796,-0.019468244,-0.001129363,-0.058194187,0.0008207112,0.03141039,0.062152717,-0.05800318,-0.054622114,0.03307868,-0.025908945,-4.252645e-33,0.074944876,-0.046791103,0.034107838,-0.06553866,-0.09343446,0.040172722,0.06654511,-0.14400296,0.047265273,-0.012300699,0.027540011,-0.03561925,-0.0044416767,-0.039990302,-0.011586439,0.016128153,-0.012452436,0.048693724,0.026332619,-0.008810082,-0.018808864,0.15675575,0.04641436,0.06549347,0.010516806,0.015547378,-0.01802427,0.033736516,0.001433721,0.04165764,-0.04847019,0.013215817,-0.038042646,-0.11006975,-0.07363935,0.05094023,-0.045220062,-0.003413067,0.019938532,0.028989121,-0.004270666,0.03667768,0.026319228,0.081157684,-0.034102134,0.04111313,-0.034549627,0.00904423,0.016848017,-0.0608449,-0.0013202681,0.0013798063,-0.06295428,-0.046810646,0.009562361,-0.02974596,-0.023313964,-0.018151829,0.0070728124,-0.060883526,-0.05259732,-0.07562945,0.030084137,-0.059933912,0.020412266,0.10109255,0.011626562,0.033964705,-2.2548224e-05,0.044958245,0.033136148,0.07121812,0.113339394,0.05625226,-0.040701672,0.063538104,-0.02683824,0.004355076,0.043060012,-0.12848811,0.013205577,0.050080005,-0.024770074,-0.030538818,0.0059432997,-0.09061255,0.043557666,0.07129381,0.022265764,0.023903433,-0.03674939,-0.07300619,-0.009091284,0.033976413,0.072318114,-3.1945405e-08,-0.030346993,-0.08144642,0.049599018,-0.07392088,-0.041126244,0.082688846,-0.026147852,-0.038107082,0.06105147,-0.013809375,-0.003456712,0.0025712282,-0.046794794,0.016790431,0.07013447,-0.02862759,-0.026016766,0.05488442,-0.06873016,-0.08715005,-0.067979954,-0.027143065,-0.09256121,0.07187786,0.04060338,-0.032720488,-0.012899386,0.063081026,0.005107121,-0.019601211,-0.0149583,-0.004516828,-0.0047539664,-0.036905378,-0.08743555,0.076849416,-0.019965872,0.008260454,-0.042218212,-0.03889735,-0.067067444,-0.030797947,0.0023059414,0.0147946635,-0.06317156,-0.033614825,-0.012771702,0.022759464,-0.0008959319,0.059485823,0.053409383,-0.08030719,-0.027405756,-0.07222774,-0.028300725,-0.009286475,-0.0058208145,-0.083358034,-0.039561328,-0.0666391,0.025485756,0.038037725,0.08398626,-0.07654699 +4.2.3.42,"This is a bifunctional enzyme which also has EC 5.5.1.14 syn-copalyl diphosphate synthase activity. Aphidicolan-16beta-ol is a precursor of aphidicolin, a specific inhibitor of DNA polymerase alpha (EC 2.7.7.7).",384,0.99999994,-0.0817249,0.02444724,-0.08610262,0.0073588667,0.06509679,0.015503891,0.00489066,0.045601662,0.045632698,-0.0026895704,0.06975108,0.03439885,-0.094520606,0.015891958,-0.07826899,0.09509088,-0.049242944,-0.016256265,0.024639282,-0.10103043,0.0528084,0.008114958,0.028192595,0.0115556335,-0.04107943,0.017031804,0.002397259,0.018802853,0.00079934485,-0.097811446,-0.026735183,0.012972003,0.06589317,-0.06469936,0.01907424,0.062026687,-0.059947833,-0.113590114,-0.022689298,0.06511032,0.116293035,0.013712966,-0.062227696,-0.04232066,-0.030968225,-0.0763962,-0.003664625,0.03678009,0.056357425,-0.026503678,0.033064473,-0.041371822,0.008538398,-0.08845573,0.009768574,-0.004682585,-0.049273983,-0.039088,0.014671379,0.043520868,0.054765545,0.027276497,0.016325712,0.014781035,0.04144451,-0.0026858717,0.10000995,-0.09315543,-0.027731549,-0.067116156,-0.09751625,-0.04737808,0.026632188,0.067506835,0.016065078,0.033929966,-0.04211686,-0.0657058,0.051073007,-0.003339816,0.011635505,-0.058756385,-0.07675246,0.035580322,-0.010004223,-0.007652267,0.07918947,0.016313823,0.017800102,-0.005031552,0.00880433,-0.0727047,-0.029248063,-0.027036054,-0.025919916,0.06544636,-0.004141006,0.009758254,-0.03874543,-0.023201425,-0.04482098,0.049507912,-0.008591308,-0.060437944,-0.036951736,-0.040783703,0.08392277,-0.0041189087,0.035960324,0.013641196,-0.053132683,-0.06648867,0.048716765,-0.037116215,-0.06368238,0.0033752278,-0.047289208,-0.047890242,0.04761566,0.09009983,0.11239973,-0.012576908,-0.024913656,0.09180752,0.0038889803,0.033010423,-0.04812387,5.988121e-34,0.09858441,0.06263864,0.003596922,-0.010581452,0.03385056,0.010283162,0.008887806,-0.025210695,-0.073259346,-0.028446315,-0.021917721,-0.05796818,0.073392004,0.0169689,-0.01275714,-0.033417363,0.049826197,-0.0008026417,0.064209156,0.005347472,0.04123311,0.07928269,-0.045781963,0.017574748,0.033181425,0.016539648,-0.12293167,0.00400274,0.094560884,0.0013241377,0.019856635,-0.022238834,-0.12303847,0.042768296,0.0517321,-0.080809094,0.013537907,-0.123418085,0.03589857,-0.0011016165,-0.030744996,-0.032360084,0.01626409,-0.03131851,0.096414685,-0.03366747,-0.09982599,0.05217606,0.08118537,0.029696347,0.030076586,0.0076755504,0.06454674,-0.03041481,-0.031045353,0.020052543,-0.057726342,-0.040092632,0.03245127,0.054758936,0.014820751,0.079930276,-0.104522794,-0.08342539,-0.027671197,0.039750572,0.0060915644,-0.0994573,0.031191634,0.017538676,0.015631571,-0.030022446,-0.009253848,0.08906563,0.034628186,0.0043051746,-0.018023798,0.0012713346,-0.015039137,0.02740205,-0.045426242,-0.009609173,0.03751449,0.025284309,-0.07740286,0.00033902013,-0.031360734,0.058835346,0.039793797,0.02895178,0.00029095565,-0.032106288,-0.026695013,0.021530602,-0.013401459,-2.154642e-33,0.076161124,-0.06290871,0.07025753,-0.102581784,-0.08004916,0.03446331,0.06015463,-0.0011702244,0.07088432,0.040132333,0.0785129,-0.03751817,0.06333327,-0.10287901,-0.012998872,0.10592816,-0.04180086,0.09495354,-0.022106813,0.023749162,-0.051340315,0.068532266,0.07777895,0.07305152,0.063478194,-0.03548015,0.05097366,-0.009639697,-0.037140224,0.008928958,-0.07005179,-0.009370467,-0.009843448,-0.021657405,-0.06652553,-0.020207891,-0.035358228,-0.039501823,-0.02452688,-0.048759446,-0.010493093,0.050801266,0.05741927,-0.014655718,0.051116936,0.08475482,-0.041924637,0.09964912,-0.021687087,-0.04050608,-0.00012531439,0.066717945,-0.009535991,-0.018619398,-0.00018599037,0.0030174467,-0.005488198,-0.048873287,0.052201305,-0.0132972915,0.055262636,-0.07432526,0.006523889,0.038616233,0.06318654,0.08111897,-0.024095863,0.00470279,0.027471539,-0.026031114,0.059007365,-0.0021937496,0.035374112,0.0035931703,-0.011559249,0.04903372,-0.031531624,-0.039315343,0.02899357,-0.07414503,-0.0031632984,-0.00650559,-0.047903944,-0.047249366,-0.054454967,-0.022617746,0.027930532,0.07105971,0.023149706,0.050499864,-0.06805246,-0.04139468,-0.043899674,0.053395055,0.058318317,-3.4500818e-08,0.096440986,-0.037634548,0.039395764,-0.05819615,0.015110635,0.0006975773,0.009503102,-0.043049786,0.12344067,0.023579156,-0.01742464,0.051518355,0.0013006305,0.010690443,0.030656999,0.005151225,-6.118482e-05,0.09317453,0.0086776735,-0.008371748,-0.037084136,0.0045046145,-0.101310365,0.05486966,0.008146857,-0.067972355,0.061745357,0.008122241,-0.009823739,-0.061702907,-0.007253523,0.033761438,0.016303089,-0.015053547,-0.06500321,0.09380653,0.006345616,-0.017434224,-0.06575772,0.06284239,-0.029159257,-0.045519914,0.013981176,-0.073326655,0.013994175,-0.012422498,0.045098014,-0.032123365,-0.0070599033,-0.07756764,0.05045945,-0.02015928,0.025121732,-0.078291796,-0.07114442,-0.08163637,-0.015572767,-0.094976366,-0.02123749,-0.075086266,0.055683702,-0.035312932,0.17971408,0.0047266213 +3.1.7.5,"Involved in the biosynthesis of plaunotol. There are two isoenzymes with different ion requirements. Neither require Mg2+ but in addition PII is inhibited by Zn2+, Mn2+ and Co2+. It is not known which isoenzyme is involved in plaunotol biosynthesis.",384,1.0,-0.026367195,-0.057211813,0.013635709,-0.033388074,0.050915867,0.006131619,-0.079177916,0.016246976,-0.011328368,-0.050472498,0.03540628,-0.035257377,0.13837413,-0.0016863695,0.030405425,0.0057572657,-0.082924396,0.063420266,-0.052012995,-0.016948141,0.15699106,-0.017492516,0.044136234,-0.022366274,-0.033403374,0.025195293,0.028679067,0.0061247456,0.06937806,-0.009305526,0.0005139918,0.049383745,0.0036597513,-0.1294107,0.028348466,0.029112801,-0.037352577,0.060702913,0.021878822,-0.016764367,0.023124412,-0.011154625,0.015559345,-0.0493581,0.017675173,-0.09376526,0.0531177,-0.05810955,-0.076951705,0.041856077,-0.017468857,-0.052147835,-0.12052706,0.04765346,0.06502031,-0.030468911,-0.09554608,0.03842144,0.0022713607,-0.039160684,-0.025717102,0.010479451,-0.060623955,-0.032372225,0.0111859655,0.011933742,-0.01579948,-0.05660444,0.015585015,-0.036377236,0.061007008,-0.043437906,-0.054984882,-0.043390665,-0.0754037,0.0515902,0.06888092,0.012202594,-0.019528167,-0.034401365,0.03134342,0.017564889,0.08717,0.06870193,0.008129203,0.0043316116,0.039358616,-0.0018266393,-0.018718584,0.06879102,0.0717431,-0.01110725,0.07164341,0.015176225,0.07832957,0.05500419,-0.10324529,0.0086356215,-0.010337269,0.018588414,0.019491604,-0.01901779,-0.057559617,-0.04060658,-0.038667794,0.027263848,0.011823003,-0.02248365,-0.01261126,0.06805242,0.047166225,-0.016030638,-0.0065926663,0.058527384,-0.016095063,0.10780983,0.05147056,-0.040524106,0.009475707,-0.07191864,0.032366864,0.010171102,0.0062051476,0.04067962,-0.042294048,-0.028121458,-0.061230853,4.700964e-33,-0.037736934,-0.0043895612,0.017882401,-0.05548472,-0.020127386,0.0033339348,-0.07243145,-0.031594798,0.03742094,-0.050357252,-0.120794185,-0.0015846646,-0.04550863,0.058195125,-0.027791042,-0.08422425,0.03508228,0.0066702333,0.08267661,0.0063813087,-0.0037892573,0.04883254,-0.025223639,0.018425206,0.0273187,0.060508467,0.014618962,-0.06383733,0.007020855,-0.033477236,0.052076366,-0.13072775,-0.008296455,0.0017194187,0.027615841,-0.043586433,-0.040796533,-0.03375892,-0.043005906,0.019387111,-0.024514621,-0.025128148,-0.14737698,0.057918154,0.092713736,-0.06700067,-0.08884077,0.0044526393,0.020059258,0.067437425,-0.018266138,0.061800145,0.03754553,0.046437304,-0.113714755,-0.019280313,-0.013021427,0.020244226,0.0074576074,0.004942786,0.01165484,0.036960363,0.109618,0.026061045,0.06508053,0.08760994,-0.14715035,-0.00879133,0.020875713,0.021342719,-0.06853077,0.0107858945,-0.010980862,-0.009250821,0.09866528,-0.083142035,-0.018053781,0.06646734,0.025237534,0.040601842,0.012265792,-0.015991218,-0.014760832,-0.034025468,-0.13293432,0.007956606,-0.029941007,-0.024104528,1.3924322e-08,0.02098845,0.054648045,0.030384166,0.0057219467,0.11500221,-0.00094664394,-5.7548765e-33,0.009064018,-0.025928427,0.15457396,-0.08259522,-0.042001788,0.05521566,-0.03633338,-0.12182703,0.0052384846,0.035743512,-0.03552223,-0.044615366,-0.009858106,-0.033604506,-0.003171536,0.06817871,-0.0022392496,0.09269706,0.012341098,0.057303406,-0.06865496,0.054973233,0.0010788754,0.025224634,0.03263901,0.051252007,0.03747153,0.018214034,0.07405771,0.0387749,0.014339211,0.016070837,-0.054402612,-0.046722252,-0.05030377,0.0023521204,0.024872344,0.049219355,-0.060700636,-0.0053223604,-0.0050000446,0.025039073,0.010827305,0.060184833,0.05682499,0.012708466,-0.029609552,-0.036774002,-0.03854019,-0.06827873,0.034871064,0.058737084,-0.025426041,0.005159995,0.08498112,-0.016848609,-0.01731123,0.03619202,0.06204225,-0.069005296,-0.014839658,-0.113508016,-0.01229653,-0.008404502,0.06492309,0.04011346,0.035009805,0.07529015,-0.019085051,0.014336293,0.05161703,-0.0010048309,0.007985236,0.008476298,-0.0105082,0.12722676,-0.024489803,-0.1396942,-0.0712591,-0.085447125,-0.009194405,0.016301278,-0.029402735,-0.065126315,-0.08464833,-0.0394016,0.06008487,0.06385126,0.03428211,-5.758264e-06,-0.019139059,-0.02371177,-0.0024997278,0.04075511,0.043676652,-3.5373215e-08,0.038203616,-0.08859538,-0.0038637363,0.04772117,-0.03229208,-0.016492324,-0.0045021405,-0.03108509,0.013484458,-0.0051037194,-0.032525275,-0.06526609,0.022322902,0.006435032,0.08317933,0.021558514,-0.030686397,0.07238024,0.026424525,-0.0064705303,-0.069657415,-0.020717975,-0.06996624,0.06754012,-0.0075475792,-0.113354206,0.03853721,0.04661511,-0.07530192,-0.017214749,0.035783462,0.014388557,-0.00959045,-0.08588905,-0.0113401,0.032497153,0.050853617,-0.037562426,0.0030230498,-0.04664707,-0.041122958,-0.07541993,0.050248716,0.006619975,0.0632647,-0.078198336,0.06825493,-0.063260965,0.04968278,-0.003346422,0.0006141957,0.010981085,-0.0050679184,-0.09111564,-0.0065454417,0.031090045,-0.003191567,-0.009852533,-0.0052128895,-0.039810482,0.014581289,0.012855482,0.08937213,-0.08685166 +1.14.13.110,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.2.1.74,"Abietic acid is the principle component of conifer resin. This enzyme catalyses the last step of the pathway of abietic acid biosynthesis in Abies grandis (grand fir). The activity has been demonstrated in cell-free stem extracts of A. grandis, was present in the cytoplasm, and required NAD+ as cofactor [1]. The enzyme is expressed constitutively at a high level, and is not inducible by wounding of the plant tissue [2].",384,0.99999994,-0.02362254,-0.023034545,-0.04710839,-0.04556147,0.04175709,0.055381432,-0.0027226564,0.046449315,0.031034598,0.04536827,-0.00843663,-0.0030926063,-0.05704567,-0.051607717,-0.03153887,0.052926674,-0.07070029,-0.016976103,-0.0668565,-0.011784469,0.08868097,0.07520321,-0.034030315,0.009392458,0.033578422,-0.09350297,-0.020396728,-0.029966615,0.08169091,-0.012606942,-0.010742194,0.019189514,0.086159766,0.03284085,-0.025626542,0.010839539,0.033737715,-0.08965383,0.07878871,0.07621229,0.10827386,0.04813128,-0.07687126,-0.040250167,-0.012597246,0.013398674,0.028190149,-0.07214976,0.007310206,-0.000503851,-0.027109198,-0.024975043,-0.055228114,-0.020648133,0.004249164,0.0117057,0.016478956,0.0027282424,0.064809114,0.028270416,0.068377025,-0.007428468,-0.009862148,0.023474814,-0.04594682,-0.021559041,-0.019643247,-0.00842273,-0.00290048,-0.07787425,-0.004470594,-0.06808113,-0.039526638,-0.07292442,-0.03364638,0.08485423,-0.0443253,0.012176572,-0.027581422,-0.0016155335,0.01948264,0.017253228,0.017029794,0.073199295,-0.012762926,0.01496069,0.04105389,0.034929786,-0.062470954,-0.06951276,0.05336287,-0.08040941,0.020511853,-0.020636879,-0.090073794,0.082255356,0.08927787,-0.14336269,0.0044115023,-0.017649878,-0.1049141,0.075552285,0.05636568,-0.054832794,-0.13167435,-0.02230965,-0.06639594,0.084796965,0.0891314,0.018382577,-0.021538587,-0.028085176,0.020332102,0.03640471,-0.041499823,0.06256386,0.013265171,-0.109469056,-0.037553377,-0.06120257,0.04970686,-0.02373614,0.097533606,0.0790295,-0.0054418733,0.008028946,0.012773762,2.3574122e-33,0.06893829,0.042403188,-0.044021424,-0.036253195,0.007578505,0.012193563,-0.119881265,0.017135328,-0.037345633,0.00266262,-0.04218872,-0.045318194,0.050083563,0.0029913485,-0.007602511,0.06956446,-0.056081545,-0.09214612,0.06390274,0.033087257,-0.029486943,0.03950427,-0.06568729,0.032935683,-0.033867627,0.0035471662,-0.009982394,-0.004010252,0.0011488065,-0.047319427,0.04333759,-0.085217744,-0.07056899,0.021445327,0.0059894766,-0.03524351,-0.05730567,-0.040760178,-0.040258504,0.02771281,-0.05128102,0.06412533,0.06977907,-0.0370263,0.101564445,-0.024768056,-0.038685422,0.040239282,0.0077035124,0.08149094,0.010239144,0.07000292,0.097616516,0.0018730229,-0.092796266,0.06793529,-0.030806968,-0.013343107,0.023161706,0.04852789,0.086572185,-0.041670065,0.018209321,0.06779541,-0.09679311,0.052647922,-0.118486114,0.008377482,0.069964014,0.0698197,-0.018295787,-0.039761946,0.02345864,-0.06704687,-0.032507878,0.046173245,0.056753922,0.019052029,-0.03677729,0.036673088,-0.035486884,0.032570574,0.0203359,0.016837321,0.019589767,-0.03353178,-0.039735224,0.032669038,0.026498428,0.0056047165,0.020855026,0.0012947021,-0.05955718,0.014547092,0.024911921,-2.3708795e-33,0.091123044,-0.07234255,0.06142532,-0.09237026,0.028943595,0.029495649,0.022660768,-0.015262184,-0.0183144,-0.031727143,0.09649972,0.069014564,-0.0007547512,0.008960327,0.0115401,0.015286121,-0.012139479,0.10480408,-0.04543257,-0.0059491484,0.03006064,0.09284169,0.017095406,-0.064754665,0.03700865,-0.015286453,-0.010270795,-0.0076346393,-0.004168321,0.016822254,0.026168177,0.015379302,-0.0934567,-0.019650722,-0.023864161,0.011747294,0.016571429,0.0020068414,-0.053455006,-0.019727223,-0.004291716,0.003568879,0.0072769974,0.05195211,0.09960897,0.024740933,-0.07907005,0.027352424,0.010128158,0.029340174,0.004083692,-0.006139585,0.0227496,-0.024319533,0.04513009,-0.010867258,0.03540147,0.011935057,-0.08670237,-0.036678445,-0.0064237635,-0.015139382,0.079989016,-0.055824876,0.025456954,0.07096044,0.000104318686,0.08503424,-0.030965222,-0.032177817,0.0884166,0.045299903,0.0019522635,0.09719568,-0.010708868,0.0076855198,-0.08221699,-0.0996215,-0.0732603,-0.003167165,-0.050057936,0.03589217,-0.067972355,-0.013466903,-0.035800457,-0.057274736,0.007668999,0.035017725,0.014346748,-0.076074645,-0.058148142,0.008741987,0.04605057,0.03658357,0.0064440286,-3.730171e-08,-0.06091473,0.02593861,-0.039807968,-0.043889116,-0.008513455,-0.02377619,-0.05858909,-0.0007744706,-0.030673787,-0.046021204,-0.024056848,0.055015035,-0.0769039,0.08373223,0.0099158855,0.023440853,-0.009376523,-0.041997474,0.00027346823,-0.037711777,-0.03757066,-0.024989096,-0.031117784,0.08668009,-0.02869703,-0.15060318,0.012023975,0.029865123,0.051521134,-0.002375455,0.041089907,0.07302805,0.046785474,0.017374557,0.006934211,-0.001997282,0.030659808,0.0642584,-0.05795545,-0.043954015,0.041290365,-0.09803886,0.024385186,-0.039224543,-0.03113601,0.009357914,0.043280803,0.07219096,0.07256019,0.06733582,0.100767896,-0.055947393,0.03301101,0.029936422,-0.061337847,-0.07093072,-0.02511095,-0.06406095,0.11344263,-0.03450106,-0.0031004925,0.021318054,0.17125899,-0.030994685 +1.1.5.3,"This flavin-dependent dehydrogenase is an essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis. In bacteria, the enzyme is localized to the cytoplasmic membrane [6], while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane [2]. In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8, glycerol-3-phosphate dehydrogenase (NAD+), forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD+ by the mitochondrial electron-transport chain [3]. This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix [7,8]. Insect flight muscle uses only CoQ10 as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ9 [4]. The enzyme is activated by calcium [3].",384,1.0,-0.08333669,-0.006344959,-0.06970541,-0.048446193,-0.0043674996,0.020852417,-0.019470152,0.0052128555,0.033470243,0.03443622,0.036858156,-0.008477121,-0.096697465,0.065125205,-0.0034409903,3.6641257e-05,0.012819277,-0.009761581,-0.016931664,-0.057725705,0.06151033,0.021159487,-0.020516658,-0.036820207,0.007132811,-0.017960008,-0.025261281,-0.007927689,-0.020801391,-0.041067623,-0.06336005,-0.027723674,-0.0527345,-0.032237113,-0.032420933,0.11239579,-0.056852583,-0.036161978,0.05253817,-0.0018229896,0.042999394,0.04240587,-0.048467625,0.010677275,-0.025803786,0.012104379,0.029915538,0.075004995,0.044133604,0.015947253,-0.057506412,-0.02384493,0.002371641,0.06934075,0.03287449,0.055061262,-0.02611257,-0.007068482,-0.068884015,-0.07673275,-0.03676371,0.004184764,0.0072239535,0.032034203,-0.037819672,-0.11028968,0.019358508,-0.07930687,0.011665681,-0.03591175,-0.063383214,-0.021482155,-0.009238508,0.0010684656,-0.08137838,0.065345705,-0.037679896,0.0044722995,0.03654128,0.026441768,0.09290434,-0.025314983,-0.00075069495,0.07326044,0.048561025,-0.012604804,0.0045750085,0.010227377,-0.049532473,0.08387172,0.04676899,-0.028865237,-0.014547821,-0.004960881,-0.124296114,0.018215435,0.038107205,0.033492792,-0.0054889456,-0.038299024,0.00061552046,0.07018407,0.06661663,-0.037433233,-0.07566066,0.007607927,0.059966065,0.08861961,0.012771209,0.029369928,-0.034122746,0.036914326,0.06163813,0.03432942,-0.042845145,0.10223456,-0.031388674,-0.04628213,0.0073062717,0.019490946,0.011239253,-0.011518012,0.03173776,0.0023785639,0.054605823,0.03798168,-0.1291827,4.4215213e-33,0.08091588,-0.0055025,-0.028156323,0.00042056874,-0.03945197,-0.036054615,-0.118192755,0.049055267,-0.048891295,-0.050735362,-0.06693441,-0.032979257,0.06899854,0.03334414,-0.012999286,0.035025407,-0.04391259,-0.059453115,0.12508656,0.014840471,0.05497976,-0.016088264,0.0051156622,-0.014388758,0.12224702,0.07294612,-0.08500839,0.023795048,-0.0141525315,0.010201532,0.06377757,-0.17100717,-0.0762927,0.024690578,0.08331708,0.022501031,-0.05695715,-0.075461894,-0.047064938,0.025412684,-0.04342192,-0.013834408,-0.004906739,-0.043453835,0.04327587,-0.09182358,-0.043673605,0.052526124,0.04210507,0.017500633,0.09837752,-0.011157383,0.18761612,-0.03689774,-0.036943685,0.03396262,0.042992532,-0.01782376,-0.043918118,0.036586754,0.0363822,0.0074385116,-0.026523223,0.048340384,0.13736609,0.023826446,-0.09135658,-0.051146474,0.018077273,0.03293439,-0.011735344,-0.06583333,0.08350243,-0.0041883504,-0.0079617165,0.010786142,0.00011927564,0.009397735,0.0052575795,-0.027441466,0.07243701,-0.01597535,0.032944612,-0.0011921811,-0.015668252,0.026726319,0.038744073,-0.049359307,0.061103947,0.013324321,0.008835568,-0.09677155,-0.011126546,-0.023955734,-0.007967495,-4.8427513e-33,0.04576074,-0.03614537,0.06283442,-0.078059144,-0.053023234,0.16843572,0.029474482,-0.061457917,0.008472032,-0.05168434,-0.039098937,0.048390575,0.03763518,-0.010940484,0.0728214,-0.0064061214,-0.076052435,0.017035695,-0.0047201216,-0.051103637,0.049617067,0.11840339,0.036747273,0.028003955,0.004160287,-0.04398353,-0.015491534,0.06935191,0.022495614,0.02772078,-0.017304994,-0.0032764901,0.011726704,-0.045366213,-0.006464606,0.023628963,-0.05788331,0.017042145,0.05302497,0.030289955,0.016914964,0.0066653476,0.015328386,-0.049835235,0.009272189,0.09389562,-0.10357132,-0.040539563,-0.035688866,-0.0044411053,0.01100012,0.047024567,-0.09990295,0.040185586,0.098759264,0.045913793,0.038007934,0.013306047,0.073522225,-0.062365726,-0.05876764,-0.06452362,0.023840528,-0.0008862743,-0.009216137,0.061930887,-0.022730831,0.054124497,-0.023517359,0.0010629491,0.0016270473,0.02381944,0.036909256,0.044373035,-0.033880543,0.03563837,0.018946573,-0.003968207,-0.003249478,0.0013748263,0.016453316,0.009057494,-0.036361806,-0.039589923,0.021113895,-0.011156734,0.0012780388,0.0826472,-0.038141776,-0.022319818,0.022092635,-0.044537455,-0.034088835,0.009239677,0.03425902,-4.982547e-08,0.0027668728,-0.017342946,0.062543266,-0.055777323,-0.0295948,0.06983933,0.11137166,-0.016925134,-0.010251098,-0.009381601,0.06406547,0.03264529,0.04526489,0.025658412,0.016360253,0.021845672,-0.07226155,0.020415427,-0.018569553,-0.028232422,-0.0617187,-0.015151457,-0.10142436,0.09360884,0.050088286,-0.060338356,-0.03777136,-0.029865036,-0.025754321,-0.038365487,-0.06293532,0.06067311,0.074338175,-0.04317181,-0.14758752,-0.053105947,-0.044144128,0.039381843,-0.064837046,0.056829974,0.010237398,-0.023640538,-0.052694526,-0.007664757,0.005485743,0.0020260145,0.048892062,0.04435572,-0.078841835,0.059366293,0.021896912,0.016950857,0.0012200298,-0.052160524,-0.11919301,-0.0067817355,-0.06628564,-0.1007617,-0.024512352,-0.021106422,0.053348374,0.01172427,0.13044374,-0.05538043 +1.3.5.2,"This Class 2 dihydroorotate dehydrogenase enzyme contains FMN [4]. The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane [2,5,6]. The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides [2,4]. The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates [2]. Methyl-, ethyl-, tert-butyl and benzyl (S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not [2]. Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. ",384,0.99999994,-0.06220473,-0.024125455,-0.07171063,-0.12974739,0.04553259,-0.009824751,-0.10017787,0.056400046,-0.025763338,-0.017223919,0.03940155,-0.0485093,-0.101895325,0.023552677,-0.017342627,0.03222946,-0.05059999,-0.056594286,0.020801893,0.0056790938,0.0007188964,-0.014018135,-0.021836575,-0.022251232,-0.022662,-0.020990241,0.038669605,0.09098601,-0.07414514,-0.008767354,-0.015658509,-0.08541432,-0.003816689,-0.01418646,-0.03732613,0.08089154,-0.02340067,-0.012158385,0.037547473,0.071417145,0.0006580409,0.007619155,-0.04459713,0.0055449936,-0.0061972863,-0.0030830193,0.06091254,0.055497456,0.021069916,0.011994442,-0.02501526,0.049084052,0.031577285,0.047017105,0.030702168,-0.0071378737,0.006513368,0.023994653,-0.10045557,0.054414485,-0.028262245,-0.026536519,-0.021382002,-0.031724982,-0.033583723,0.0008591181,0.021321932,-0.06924196,0.005328756,-0.062371567,-0.038842108,-0.09746473,-0.005574754,-0.019994548,-0.08631251,0.08043402,0.017655322,0.01886074,0.035837118,-0.03887902,-0.0069285054,-0.07914776,0.042005878,0.007388957,0.044964682,-0.028693734,-0.07629275,0.018652448,0.039133586,0.08762366,0.051392283,0.03653395,-0.016505554,-0.09531695,-0.024228266,0.10180575,0.022629576,0.08779802,0.041557416,-0.015123066,0.03768268,0.032378517,-0.09571435,-0.08949789,-0.064759314,0.027986158,0.027455198,0.06750428,-0.04613578,-0.020219402,-0.03895607,0.004111816,0.032906406,0.00048620655,-0.029229686,0.064581715,0.04688939,-0.066195525,-0.011538921,0.016356578,-0.029678728,0.015701015,0.12449224,0.064350486,0.04454566,0.0021379371,-0.121022075,1.9553838e-33,0.027128516,0.08143106,-0.018292157,-0.03864276,-0.02551385,0.019830802,-0.09218141,0.08392297,-0.07146768,-0.082315736,-0.060772322,-0.037943993,0.051627386,-0.047508564,-0.036779877,-0.017226122,0.0341235,-0.009590438,0.027247304,-0.046542753,0.032221686,0.012244949,0.034413602,-0.06422159,0.028141141,0.06850731,-0.024024261,0.05153693,0.019559273,-0.00781855,-0.05521749,-0.15635227,-0.01483152,-0.017863715,0.00823246,-0.03077967,-0.14319849,0.017145876,-0.044207055,-0.0035799288,0.01741315,0.040462006,-0.0019882843,-0.0008336122,0.05710012,0.01157195,-0.0106301755,0.047661666,-0.004198241,0.020236949,0.050448164,-0.027102368,0.049027883,-0.07412381,-0.052999724,0.008288591,0.048609264,0.057388943,0.046208303,0.08156287,-0.004667506,0.07583766,-0.035927013,-0.00035636182,0.061549466,-0.046869714,-0.06144643,-0.01673472,-0.0037457515,0.07099496,0.029846907,-0.04262704,0.14949176,-0.023289163,0.08681331,-0.022431511,-0.013772959,0.005124083,0.030141061,-0.08195045,-0.025917683,-0.034844812,0.01101901,-0.009130695,-0.08413095,-0.007035317,0.014654314,-0.014222839,0.013974508,0.05045828,0.053318,-0.06781461,-0.047402825,-0.060853727,0.08478225,-2.8756803e-33,0.04790682,-0.029009452,0.012630483,-0.08453258,-0.0012644253,0.1210956,0.03557247,-0.032201644,0.04044487,-0.03386102,0.09387767,-0.040693887,-0.013668757,-0.040029146,-0.032943796,-0.01751858,-0.017322306,0.07335569,0.048058823,-0.035581432,0.02128391,0.078781866,1.5142003e-05,0.078523554,0.029735515,0.0015091344,-0.011627051,0.027100408,0.0894671,0.031985745,-0.08665016,0.060863655,-0.00049626926,0.04021605,0.057321504,0.03954413,-0.06717955,0.033240706,0.019879552,0.09187852,-0.010099172,0.0141867045,-0.03658212,0.042611293,-0.039705813,0.079576805,-0.12456439,-0.01359006,-0.022497121,-0.013582358,0.040130276,0.0093615055,-0.053686474,0.03247132,0.07510612,0.059351988,0.022186795,-0.048329957,0.01940167,-0.020011306,-0.058275975,-0.1066016,0.015687956,-0.0073307035,-0.0044492693,0.023946278,-0.062241524,0.11144359,0.0056334813,0.0131233875,0.039115734,0.012507506,0.02060622,0.03999869,-0.06444147,0.021606214,0.053592343,0.00034712654,0.020823715,0.028256329,0.018126493,-0.040237352,-0.049681883,0.029196149,-0.020986436,-0.07650951,0.052192383,0.077340245,-0.010990592,-0.029057419,0.036589727,0.03245787,-0.026436558,0.08850354,0.048014544,-4.4965716e-08,0.02890625,-0.10708225,0.062250957,0.005916403,0.017778978,0.039142337,-0.025595028,0.030109597,0.00017809955,-0.0025081232,0.016837182,0.071867,-0.0014200987,-0.025342278,0.053965297,0.011879356,-0.050348777,0.005106954,0.0030072741,0.06919602,-0.021344976,0.021759741,-0.16755977,-0.032008745,0.027096575,-0.053483587,-0.035293825,0.0021939501,0.008872577,-0.02339597,-0.011689801,0.0022190993,-0.0005565619,-0.02287229,-0.06368537,-0.0118353665,-0.051974144,-0.013222362,-0.075280346,0.018595794,0.023752365,-0.06394911,-0.07890714,0.015033198,0.04926648,0.006904119,-0.00074306893,0.060115524,0.0016350576,0.02656011,0.00970707,0.035542056,0.07281941,-0.08129639,-0.08898533,0.035855018,-0.06670995,-0.09269057,-0.050243184,-0.060513724,0.10065555,0.018568158,0.17762235,0.03637312 +3.1.3.79,"This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ for activity. Mannosylfructose is the major endogenous osmolyte produced by several alpha-proteobacteria in response to osmotic stress and is synthesized by the sequential action of EC 2.4.1.246 (mannosylfructose-phosphate synthase) followed by this enzyme. While mannosylfructose 6-phosphate is the physiological substrate, the enzyme can use sucrose 6-phosphate very efficiently. The F in mannosylfructose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.",384,1.0,-0.01846821,-0.06018585,-0.08237563,0.0023038972,0.07519438,0.033255197,-0.08509283,0.06815085,-0.02818996,0.08267337,-0.0043067145,0.020451449,-0.01488855,-0.053926352,-0.063928016,-0.015374528,-0.05626411,0.04180157,-0.029186761,0.016727163,0.11851976,0.0028926115,-0.05344083,-0.06796625,0.043121994,-0.0130862,-0.025418123,-0.009218057,-0.03383027,-0.062059965,-0.025223503,-0.02577993,0.10020006,-0.07173139,0.11587892,0.11043162,0.01914976,-0.11470369,0.0578177,-0.044899505,0.0028613869,-0.06013105,0.03152468,-0.029233055,-0.02013868,-0.0316965,0.016537676,0.0394202,0.057755504,-0.021537825,-0.029006088,-0.013709067,-0.020740032,-0.018454151,-0.017852593,0.052824706,0.0404606,-0.07329579,-0.018466342,0.03229615,0.020460268,0.012618546,0.021931885,0.0009865296,0.06831215,-0.048900377,-0.008101802,-0.10367051,-0.043468606,0.0045277574,-0.08300847,0.00882556,0.030988459,0.047131307,0.0077373898,0.040832758,-0.019522203,-0.03696679,0.044073228,0.02436672,0.04910475,-0.016269987,0.037372857,0.00946645,-0.042493265,-0.07249736,0.06407411,0.015361485,0.08138503,0.10275796,0.0074046063,0.016729504,0.08345293,-0.039148286,-0.04655054,0.045030124,-0.06824557,-0.00074015785,0.0374404,-0.033093307,-0.039171714,0.02201432,0.047114383,-0.056446962,0.020277252,-0.0014067935,-0.09390379,0.046446156,-0.0039591687,0.10181645,0.05467611,0.00046956714,0.0009001617,-0.030761728,-0.02838033,0.010285245,0.019955168,-0.07434885,-0.04617126,-0.026068188,0.05296967,-2.598782e-06,0.030611357,0.00567789,0.002594048,0.0031873346,-0.07816167,4.787262e-33,0.048534755,-0.019235691,0.066578746,-0.048947588,0.048668902,0.01647678,-0.09515863,-0.012104726,-0.04969442,0.03168942,-0.11547812,-0.019619975,0.013423363,-0.00022856003,-0.011685628,0.047698293,-0.043058556,0.03211522,0.009252384,0.06594475,0.026600776,-0.014782767,0.01330982,0.027212024,0.076853506,0.027883252,-0.00016224103,-0.047243234,0.042650316,-0.031221172,0.09618006,-0.11077927,-0.078443415,-0.022580098,0.07438168,-0.08896398,-0.051073294,-0.008958008,-0.03069108,0.034722738,0.045481183,0.08121377,0.038944405,-0.034617305,0.09472182,-0.05704623,-0.0012418301,0.103374735,0.072123855,0.07418996,0.057520427,-0.019253625,0.046607774,0.053790476,0.0146478815,0.0027186004,-0.014777037,0.018850125,0.0796737,0.0478758,-0.02268319,0.003787071,0.04731613,-0.014919797,0.008574416,-0.035687506,-0.033259727,0.04197687,0.019076506,0.07395099,-0.043319073,-0.03660482,0.021420227,0.060501017,-0.04961825,-0.07847526,-0.03700481,0.023322748,-0.03381986,0.0065184208,0.069373034,-0.0102338195,-0.015957152,-0.008882893,-0.08738127,-0.008927675,-0.13607255,-0.055537466,0.0028131038,0.010424846,0.05820399,-0.025184507,-0.14987713,0.024032634,-0.056105617,-4.4616094e-33,0.14054802,-0.03927115,0.063894,-0.022173317,-0.037029646,-0.010009188,0.047571257,-0.011816444,0.05003073,0.0048467284,0.04869611,0.018639838,0.09307724,-0.049050696,-0.006086963,-0.031801093,0.021331454,0.08041181,-0.065236524,-0.016716026,-0.040068027,0.1109558,0.023730733,-0.033253193,0.07764632,-0.030391207,-0.016989818,0.06112409,-0.060820606,0.06215874,0.03909926,0.03792123,-0.003715117,-0.06783694,-0.09590348,-0.02181179,-0.066112414,-0.009888189,0.030237434,0.05375096,-0.006329021,0.08491553,0.06522208,-0.03011332,-0.02426803,0.014320594,-0.04510887,0.0026459163,0.016368452,0.007881246,0.0196072,-0.07882151,-0.03997626,0.009018943,0.058943447,-0.005696631,-0.057435337,-0.0036595352,-0.06827751,0.015701475,0.044933952,-0.026814166,0.113659844,-0.031996332,0.047564257,0.08698641,-0.029176937,0.09822656,-0.038368482,0.04021265,-0.014432249,0.06168843,0.027760267,0.044968333,0.029034978,0.035712007,-0.09387076,9.347547e-05,0.0050409725,-0.007086505,-0.029526325,-0.018259227,-0.035790354,-0.017549612,-0.017728567,-0.040869858,0.037336543,0.08742982,-0.03021292,0.081857584,-0.103095405,-0.019088423,-0.010954581,0.055280466,0.073550664,-3.8629196e-08,-0.014582236,-0.006300283,0.02234865,-0.06584759,0.059196476,0.050863218,0.014069215,-0.037976503,0.03966823,-0.05850482,-0.032282993,0.07318051,0.006262598,-0.036201984,0.023264363,0.015011373,-0.01918218,0.003349498,-0.06107652,0.020742754,-0.045292933,-0.025448086,-0.12253965,0.077272765,0.073810264,-0.0137619255,0.018936187,-0.027126912,-0.025408579,0.03342969,0.008849443,-0.012752993,-0.0071407943,-0.097377494,-0.08311809,0.055726204,-0.037157156,-0.08102268,-0.005737433,-0.016060557,0.01369492,0.007634617,-0.051419422,-0.027456107,-0.067252256,0.041325025,-0.079899825,0.07102376,-0.09330767,-0.013618084,0.013202135,-0.0196118,-0.08196619,-0.016367232,-0.005988551,0.034495648,0.048451707,-0.045181133,-0.00054465554,0.034103803,0.031976417,-0.042326063,0.1706275,-0.037420746 +2.4.1.246,"This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity. GDP-mannose can be replaced by ADP-mannose but with a concomitant decrease in activity. The product of this reaction is dephosphorylated by EC 3.1.3.79 (mannosylfructose-phosphate phosphatase) to form the non-reducing disaccharide mannosylfructose, which is the major endogenous osmolyte produced by several alpha-proteobacteria in response to osmotic stress. The F in the product name is used to indicate that the fructose residue of sucrose carries the substituent.",384,1.0,-0.010160128,-0.055372145,-0.06301594,0.008917626,0.10579571,0.01866556,-0.010402441,0.074988835,-0.011885221,0.09515501,0.019544661,-0.018481122,0.013584024,-0.046523556,-0.07268228,-0.012340885,-0.04255846,0.02102993,-0.038996007,0.03393729,0.13838266,0.013404902,-0.047845762,-0.062140055,0.044091843,-0.030224172,-0.012177633,-0.0213563,-0.07450507,-0.07017165,-0.019390384,-0.01598772,0.13414879,-0.06985277,0.12884866,0.11965483,0.013278502,-0.104176685,0.017936962,-0.051884834,0.017391551,-0.04564675,0.020651456,-0.013800614,-0.028810201,-0.02514349,-0.00717349,0.04303071,0.02795998,-0.0014676829,-0.03071722,-0.011783199,-0.022892633,0.040607452,-0.035410404,0.046188753,0.03067723,-0.05783026,-0.059410326,0.022459555,0.0044434844,0.0035872846,0.017510384,-0.020567512,0.10319637,-0.03114855,0.013754491,-0.10988509,-0.0455099,0.04358015,-0.047940455,-0.0016814341,0.026474461,0.01788412,0.012555544,0.04444775,0.0027941787,-0.038824327,0.051070046,-0.0019269589,0.039832514,0.01573244,0.054486852,0.015432059,-0.026647972,-0.0717094,0.005920388,-0.02123087,0.08573666,0.087089114,-0.040250335,0.011175467,0.08093071,0.015059252,-0.035736706,0.0609843,-0.06299772,0.02191173,0.041704666,-0.0112142535,-0.052999757,0.045593034,0.03013682,-0.06907683,0.008576947,0.010670983,-0.077349685,0.034515508,-0.0049546226,0.11757107,0.064216696,-0.0075230026,-0.0045571825,-0.014679407,-0.04404488,0.008898047,0.025991717,-0.11153994,-0.031750876,-0.04943622,0.06987008,-0.022005577,0.015106817,-0.003980157,-0.010999096,0.012526774,-0.08476808,4.1828912e-33,0.03075565,-0.025681794,0.051125318,-0.03663424,0.06402343,0.003201576,-0.09409968,-0.037619684,-0.0348861,0.01346445,-0.14478149,-0.021431003,0.014396839,0.008904556,-0.052103426,0.028203672,-0.049091134,0.040204316,0.04651872,0.046421368,0.017265901,0.002985763,-0.026263842,0.014023907,0.082032055,0.015323109,-0.02092827,-0.04566927,0.064495906,-0.024743933,0.13003114,-0.10058098,-0.08945091,-0.04824923,0.05027055,-0.078532785,-0.06615001,-0.020486161,-0.042649798,0.022861805,0.03504114,0.08233776,0.024305629,-0.028524827,0.08204603,-0.057002943,-0.0018691013,0.086838506,0.054099668,0.070008464,0.06150021,-0.023289004,0.05098582,0.010775197,-0.016606633,-0.0012762484,-0.044384096,-0.003126615,0.07316215,0.057944458,-0.012987781,0.020140862,0.055307757,0.007796671,0.00095458864,-0.021340102,-0.03535601,0.03157378,0.016734974,0.05864748,-0.05678101,-0.062429357,0.035407193,0.051075693,-0.036517475,-0.07838259,-0.020677289,0.015155716,-0.040342927,0.016457004,0.059434157,-0.036370922,-0.03834433,0.0064073945,-0.08252224,0.008301061,-0.1089099,-0.062448777,0.0056847217,0.00101542,0.05105996,-0.0070365574,-0.16017601,0.05384192,-0.07628533,-4.6069174e-33,0.09799241,-0.046395484,0.049403723,-0.025140058,-0.039397996,-0.0019299459,0.048723422,-0.00030074053,0.064929806,-0.011561341,0.0817072,-0.011232749,0.064971656,-0.060763396,-0.0036966375,-0.015714921,0.026490558,0.06101697,-0.077907234,-0.0008471992,-0.04385133,0.13086356,0.019848978,-0.019078026,0.06518606,-0.030219778,-0.012768607,0.07385218,-0.034128986,0.060378276,0.039864354,0.04504011,-0.0077567054,-0.07084278,-0.08621813,-0.015978659,-0.053896777,-0.04372548,0.025894323,0.049476273,-0.0058448105,0.056760933,0.07369162,-0.029444957,-0.009550402,0.03166715,-0.06306155,0.022828627,0.021093283,0.007080926,0.041219145,-0.075485155,-0.043821312,-0.0034581276,0.06805802,0.027325964,-0.04791913,0.0063764313,-0.06524177,-0.008452514,0.039429095,-0.015084622,0.11200251,-0.01574259,0.05928901,0.08604232,-0.04070054,0.06873594,0.0057718153,0.044591572,-0.01004805,0.078652665,-0.005104281,0.015812105,0.02268172,0.012640707,-0.11024932,0.008553657,-0.0046169832,-0.019000111,-0.021611137,-0.02255137,0.007790447,-0.016593823,-0.017640658,-0.04904003,0.016910307,0.09771441,-0.024518589,0.082591616,-0.112205595,-0.050464086,-0.05423002,0.06878375,0.04832903,-4.155394e-08,-0.0068618953,0.019118661,0.02886334,-0.06641427,0.050078876,0.027508577,0.009896555,-0.04258136,0.04346812,-0.03204476,-0.00823967,0.084800415,-0.0036184592,-0.04011075,0.016121013,-0.00559932,-0.004795607,0.029917857,-0.06200107,-0.0031801036,-0.039196886,-0.005812965,-0.11410911,0.06667124,0.093814515,0.010837316,0.029252173,-0.013846656,-0.024427924,0.0011314433,0.017141173,0.018245399,0.0067494786,-0.09126734,-0.08794128,0.053987626,-0.041367147,-0.08896567,-0.019025,0.000117668234,-0.02782927,0.024301263,-0.01307143,-0.0010215553,-0.06825552,0.022305537,-0.07065474,0.063352875,-0.07638996,-0.028387923,0.025561728,-0.021172708,-0.10448372,-0.004168054,-0.018851375,0.008853654,0.034412224,-0.0524208,0.012384624,0.023372833,0.05638688,-0.045878965,0.13457325,-0.043705355 +1.14.13.107,"A flavoprotein (FAD). Limonene is the most widespread terpene and is formed by more than 300 plants. Rhodococcus erythropolis DCL14, a Gram-positive bacterium, is able to grow on both (S)-limonene and (R)-limonene as the sole source of carbon and energy. NADPH can act instead of NADH, although more slowly. It has not been established if the product formed is optically pure or a mixture of two enantiomers.",384,1.0,-0.068810426,-0.101316445,-0.11660851,0.0026446402,0.05178199,0.068753846,-0.033990785,0.07150281,0.092667796,0.019516485,0.048728216,-0.04933348,-0.08892107,-0.005501772,-0.047667928,-0.0063284165,0.00058348005,-0.00023340121,-0.08085925,0.014418788,0.013855915,0.038696706,-0.008508898,-0.02171665,0.04371456,-0.0064113294,-0.006183307,-0.014947591,0.025653472,-0.04829903,0.008198542,0.046715375,-0.0029250113,0.006367097,-0.0056358175,0.021805534,-0.016032081,-0.006324778,0.095499605,0.03310283,0.02363953,-0.076684065,0.07151186,-0.09582711,0.0031948085,-0.0069951774,-0.053729996,0.088020824,0.055455435,-0.111477196,0.007760721,-0.026275441,-0.08471049,0.051630348,-0.0012468462,-0.042274013,0.05000946,-0.029438205,-0.009655081,-0.0070777726,0.055155773,-0.044427305,-0.0052502546,-0.0071397186,-0.049386058,-0.043143317,-0.04301961,0.0132481605,0.066543125,0.00068330363,0.0050696083,-0.016360572,-0.06774515,0.09075532,-0.026377793,0.09896573,0.0141578335,-0.010211113,0.03968321,-0.019210689,0.08582549,0.06094051,0.0070318105,0.03450315,0.050103314,-0.023980644,-0.004123771,0.026465693,-0.0025168466,0.0917339,-0.0026097426,0.08812949,0.01565438,-0.029108962,-0.13838856,0.07410452,0.13200486,-0.1033197,-0.035501968,-0.019407969,-0.02819758,0.04110559,-0.01631832,-0.08630742,-0.07906501,-0.007523481,-0.064526886,0.018348522,0.03221251,-0.05882864,-0.006118122,-0.027106762,-0.016993968,-0.073024206,-0.05525288,-0.017532468,0.009313766,-0.05314679,-0.053689502,-0.03631046,-0.0857868,0.03230559,0.03250171,0.025591636,0.047194712,-0.051450163,-0.07987678,1.8307256e-33,0.10740552,-0.008731485,-0.007996106,0.01738004,0.041212138,0.04496746,-0.069395676,0.060289167,0.03747274,-0.11456634,-0.07774499,-0.058880128,-0.042109597,-0.016618468,0.032854978,0.044950202,-0.051094808,-0.010888385,0.011156313,-0.10350429,-0.025697403,0.05501456,0.003787323,-0.015851844,0.029091224,-0.02852646,0.008172247,-0.0025742073,0.0068209805,-0.004318273,0.014135297,-0.0679449,-0.007717844,0.029147113,0.0092587955,0.022507336,-0.10620582,-0.053508177,-0.03287138,0.032696176,0.028648568,0.049100313,-0.011577597,-0.025375579,0.016934354,0.00768843,-0.086965024,0.021540282,-0.013599302,0.084570274,0.036461513,-0.013299072,0.09557012,0.083445415,-0.046892144,-0.015122556,-0.032061588,0.028315209,0.051632058,0.029414399,0.039238494,0.1147662,-0.030125408,0.04705048,-0.044157103,0.055674948,-0.12580629,-0.026871042,0.029019218,0.1268855,0.0881216,-0.011739166,0.063863456,-0.048970252,0.111279935,-0.008075285,-0.016615009,-0.00032536202,0.0006616819,0.032446716,-0.0657847,-0.03539836,-0.016020544,-0.04582501,-0.09995123,0.019737424,-0.035875224,-0.021029878,0.006297837,0.031169217,0.030596498,-0.08159845,0.00560101,-0.015185448,0.0021612216,-1.9320824e-33,0.059383426,-0.08380646,0.04944644,0.0041391198,0.032056674,0.042934906,-0.06448012,-0.060053065,-0.0474808,-0.06548973,0.067601554,0.023870125,0.05121151,0.0554713,0.037333097,-0.05391516,0.009130931,0.021727625,0.01822572,0.007741897,-0.0777338,0.009454437,0.025045525,0.09357478,0.085337885,-0.070037276,-0.052607693,-0.0030228447,-0.036381193,0.03904212,0.072666734,0.035325006,-0.07158733,0.015804099,-0.08376884,0.04981228,-0.00019540211,0.0022341737,0.008603045,0.103122294,0.03143246,-0.046535004,-0.04555961,0.05665253,0.028842667,-0.022113584,-0.056042556,0.0037666277,0.08195441,-0.0071924613,0.08436667,0.03769397,-0.020432707,0.050300274,0.046305355,0.036702078,0.025686804,0.07593635,-0.0057895794,-0.021461898,-0.05058673,-0.10824723,-0.025263056,-0.017035201,0.074991144,0.028170504,0.0034055791,0.11098029,0.041538775,-0.042995084,0.13343014,0.06187283,0.036514603,0.04155695,-0.031514406,-0.04211349,0.053636495,-0.062091142,-0.0095504075,-0.006621128,-0.024239276,-0.032049257,0.009644924,-0.0018998004,-0.0820524,-0.07612378,0.028428093,-0.028968286,-0.0305317,0.065743,-0.03143463,0.0754528,-0.011917691,0.040057395,0.114225924,-4.0617316e-08,0.046856575,-0.028541727,0.01736631,0.053225845,0.019932847,-0.012503382,0.065394185,0.012597928,0.008816397,0.017219309,-0.037369702,0.065116465,0.013062216,0.010338491,0.08702309,-0.013765984,-0.048186082,0.0100068515,-0.023330446,-0.029271727,-0.013688478,0.00089118106,-0.097320266,7.6278746e-05,-0.038459465,-0.103432104,0.029313818,-0.034642927,0.030202921,-0.07070495,0.05762475,-0.0014228947,0.0008620176,0.033160914,-0.03205794,0.008196183,-0.056127656,-0.026816439,-0.049455244,0.05068026,-0.049526792,0.02068525,-0.08334304,-0.012887751,-0.0451835,0.012900334,0.028342444,0.0067548337,-0.028295593,-0.0054386253,0.0098760305,0.021696089,0.09043393,-0.028359074,-0.049990617,0.0026187235,-0.02858276,0.037704457,-0.020000668,-0.024159642,0.0026328182,0.018295912,0.15168707,0.052959234 +1.17.7.1,An iron-sulfur protein found in plant chloroplasts and cyanobacteria that contains a [4Fe-4S] cluster [1]. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis. Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC 1.17.7.3). The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin [1].,384,1.0,-0.0906555,-0.028486272,-0.12991084,0.0954925,0.09753557,0.034812097,-0.016755167,0.009678619,0.037290752,-0.092783764,0.042235725,-0.029010702,-0.0636286,0.004610396,-0.03579468,0.03859972,-0.04224489,0.058344863,-0.048271585,-0.041529275,-0.003980022,0.0026709617,-0.03271687,-0.04636642,-0.0037790101,0.024154518,-0.00020916057,0.014980554,-0.034181606,-0.076743655,-0.021241352,-0.012166132,0.08271001,-0.05654816,0.022226846,0.09593015,0.011451581,-0.12802903,0.05829341,-0.04759629,0.011204926,0.027502632,0.01570903,-0.020904185,-0.044104587,-0.045771293,-0.013139398,0.020020632,0.035831124,-0.03488434,-0.07583592,0.008695345,-0.029048108,0.072791375,0.026236331,-0.041476622,-0.0063037705,-0.056613572,0.021309916,-0.0152342245,0.06454851,-0.031920146,-0.0014586039,-0.00040234436,-0.045322087,0.02031248,0.0015016347,-0.02730792,0.05292998,-0.055905093,0.0031880587,0.006883373,-0.045568176,0.0734338,-0.029821692,0.10496573,0.08341002,-0.024019219,0.01773412,-0.00460049,0.042287547,0.010798387,0.041880056,0.10367165,0.028884463,-0.039288398,-0.08433881,-0.021569077,-0.02192634,0.043258153,0.03366043,0.06836658,0.0028267351,-0.03989546,-0.043723304,0.04668951,0.00940293,0.018188547,-0.022116682,0.0033801852,-0.05404125,0.04681976,-0.048490886,-0.08906402,0.0315736,-0.016095223,-0.007551186,0.08304824,0.025234431,0.003823508,0.0071465704,-0.062258754,-0.004792034,-0.033859536,0.010407224,0.03892215,0.04393743,-0.057926342,-0.08621362,0.02966836,0.010114206,0.01852227,0.017252477,0.0398944,-0.029907275,-0.025330476,-0.20377176,3.308111e-33,0.104371585,0.033754583,0.029745486,-0.035476282,0.031756155,-0.044863287,-0.05861517,0.022956906,0.0062072263,-0.03703095,-0.13268508,-0.029922174,0.046219688,-0.08289362,-0.0025776713,-0.07062465,-0.0564561,-0.024970952,0.072658494,0.026756493,0.011610227,0.038598068,-0.042080253,-0.0041559436,0.011842152,0.07010385,-0.010490551,-0.02948499,0.010100688,-0.0056489836,0.008876948,-0.06900447,-0.068241395,-0.003924595,0.13639742,-0.06359578,-0.016332706,-0.01764513,-0.10283919,0.037411593,-0.05900239,0.06407224,-0.04636144,-0.06033789,0.11192309,-0.05314621,-0.0857723,0.096241005,0.0827822,0.06759797,0.042617593,5.171523e-05,0.088633776,-0.031924125,-0.07571729,0.01662273,0.012512536,0.039198503,0.057558607,0.025380336,0.0035275545,0.038632244,-0.004941789,0.007193493,0.021459982,0.06376369,-0.023501994,-0.009390165,0.0033074485,0.09260442,-0.00643365,-0.031792797,0.0008371468,0.024905305,0.06786047,-0.069618985,-0.058053244,-0.03332543,0.054665957,0.03643779,-0.017969437,-0.04407284,-0.03156064,-0.040328078,-0.04942409,0.003369005,-0.046305276,0.012868746,0.028930394,-0.0017155188,0.052631658,-0.00409816,-0.05120881,-0.030595798,-0.036163364,-3.756272e-33,0.043837965,-0.06639292,0.009621687,-0.033539187,-0.06297492,0.052804746,-0.025375644,-0.019201186,0.018841136,0.099992104,0.1278398,-0.022930656,-0.0054353196,-0.029853854,0.024060423,0.08491052,0.004922311,0.02856789,-0.002572216,0.03156901,-0.04552824,0.034366548,0.0074711116,0.051223293,0.034884762,0.017202383,0.012695869,0.0063859774,0.042843495,0.054115023,-0.030762486,0.008657189,-0.038325373,-0.08913361,-0.02417586,0.019018134,-0.061556038,-0.0019664483,0.0292718,0.009877148,-0.0032348533,-0.009471106,0.007957848,0.11987093,0.009698379,0.010526367,-0.089240834,0.047216553,-0.026643472,0.017024918,0.010116963,-0.022174494,-0.077352576,0.071925044,0.0026249054,0.004773217,0.073060244,0.102494694,-0.024779541,0.07130505,0.027064027,-0.15259083,0.04831424,0.007062781,0.09788322,0.09784423,-0.010076894,0.06711939,-0.025210276,0.02019167,0.053040244,-0.027024608,0.06955145,0.004057979,-0.009919998,-0.0026704094,0.010177192,0.041722592,-0.07298762,0.04412022,-0.018564938,0.013600955,-0.010083187,-0.04345224,0.00018186394,-0.104613215,-0.0042874883,0.055028178,-0.016531808,0.049370732,-0.016052715,-0.0011544239,0.013590149,-0.009329474,-0.011621919,-3.7781895e-08,-0.057106506,-0.045732204,0.07571333,-0.0066606025,0.025765529,0.0027360846,-0.015075718,-0.030081833,-0.0060272138,0.030125478,0.041481733,0.09237871,-0.0031724614,-0.05992025,0.03384106,-0.010107484,0.0126854945,0.035445474,-0.0020206245,0.08569208,-0.057078287,0.010523003,-0.14556596,-0.004875116,0.054727267,-0.07271331,0.0070636403,-0.053361673,0.07854905,-0.036314048,0.03785357,0.042450983,0.005312586,-0.069250904,-0.14089562,-0.01235563,-0.04284725,-0.07732198,-0.0843419,0.0119847935,-0.074438915,0.045251764,-0.090890095,-0.0026752213,-0.011108442,0.013095649,0.042450953,0.037628427,-0.030866435,0.039227635,0.024106035,-0.056569126,0.04759106,-0.05570542,-0.053546503,0.04545565,0.08188369,-0.0074460013,0.02460477,0.0180419,-0.0011732944,-0.0534949,0.14710163,0.015482739 +1.17.7.3,A bacterial iron-sulfur protein that contains a [4Fe-4S] cluster. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria [2]. Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).,384,1.0,-0.032433305,-0.0342053,-0.11167251,0.09176665,0.07977589,0.06140578,-0.0491289,0.0135042025,0.041229475,-0.10136892,0.017957112,-0.069317885,-0.036975954,0.016152639,-0.07115196,0.029290665,-0.024390066,0.062707655,0.011122674,0.0022404396,-0.011672393,0.027725717,-0.00292723,-0.043264013,-0.023361135,0.04224865,0.0077310116,0.02814132,-0.007508471,-0.038227227,5.474231e-05,0.005176446,0.097531855,-0.059103798,0.051167186,0.090685084,0.0428635,-0.06788748,0.058928464,-0.028286146,-0.018765215,0.027023703,0.051512755,-0.024014354,-0.012080808,-0.009769891,0.008990948,0.004812754,0.03991959,-0.064428136,-0.09773947,-0.018516118,-0.0696433,0.11244937,0.04165096,-0.032025546,-0.02077081,-0.06990956,0.017627412,-0.012749837,0.09746521,-0.0471471,0.045019846,-0.0011887059,-0.015459964,0.023541797,-0.017779293,0.0013300058,0.054852515,-0.04893865,-0.0051120603,0.0141127845,-0.043928586,0.07717048,-0.039480314,0.09950436,0.057158444,-0.038413275,0.04817801,0.0070163864,-0.03146374,0.0206065,0.015021439,0.072922,0.022263866,-0.049151998,-0.034669053,-0.03870594,-0.018113779,0.0624995,-0.00027233348,0.02542777,0.0047448697,-0.067538545,-0.028255474,0.020816576,0.04033008,0.011900804,0.043973695,0.006983019,-0.05802587,0.050439905,-0.043034125,-0.08785422,-0.00036516823,-0.027854031,-0.025034957,0.10733451,0.033148497,0.025324006,0.018544946,-0.047359057,-0.011069044,-0.058723744,0.018503234,0.03225079,0.073117375,-0.027179942,-0.08197658,0.06888689,-0.005465636,0.031946022,0.032391667,0.046852253,-0.0024019168,-0.038143687,-0.20791177,9.23365e-34,0.115916125,0.052726258,0.04890242,-0.032597627,0.035984702,-0.054062884,-0.057669334,-0.023356682,0.023153137,-0.021234352,-0.13406006,-0.0344046,0.059401415,-0.076237045,0.0051028505,-0.070263915,-0.06579088,-0.02767937,0.09965554,-0.024828266,0.0076218187,0.06782561,0.016998265,-0.033120744,0.028463537,0.05350288,-0.0071770074,-0.030717637,-0.009299612,0.008971355,-0.0042825397,-0.06258853,-0.09655633,-0.034221627,0.12631375,-0.07250021,-0.0129045565,-0.06846864,-0.07399046,0.037633978,-0.051377002,0.025922703,-0.013063846,-0.08141967,0.113006495,-0.06386084,-0.06425488,0.07902285,0.06502095,0.049640793,0.015166719,-0.030037671,0.089765035,-0.021337157,-0.10644915,-0.015832592,-0.006956747,0.02574156,0.032482445,0.049548175,0.008615476,0.04095027,-0.019584179,0.020240435,0.017940518,0.024835046,-0.022899631,-0.002234164,0.027228052,0.10204808,-0.0075188326,-0.036910918,0.022613904,0.001481257,0.041172057,-0.07387542,-0.074531466,-0.043037586,0.077153966,0.007958626,-0.05224654,-0.046253998,-0.05321929,-0.03988471,-0.023295451,0.02750805,-0.036640834,-0.009163136,0.034853257,-0.02108033,0.03137909,-0.029953232,-0.052717384,0.024350854,-0.0729868,-2.1933296e-33,0.04108434,-0.08786446,0.030515047,-0.01184219,-0.06965377,0.04417064,-0.016202416,-0.012198306,0.0054631345,0.06860455,0.10070355,-0.053420704,0.046418052,-0.0426519,0.002210062,0.07161713,0.01367334,0.014519108,0.03948995,0.040904906,-0.022380162,0.023113666,-0.0028992414,0.026603553,0.029739747,0.008822906,-0.01669708,0.008312811,0.040297836,0.087028995,-0.012419928,0.015583481,-0.038987502,-0.12945767,-0.044500522,0.018887563,-0.05287316,-0.0024109748,0.06191145,-0.023664705,0.032331318,0.020314883,0.0034234035,0.13600941,0.023926208,0.012205471,-0.06500586,0.07829915,0.0025056922,0.011302057,0.007083294,-0.0611726,-0.057907876,0.030750971,-0.010801585,0.0064541358,-0.009671349,0.10535931,-0.032297276,0.067793205,9.532921e-05,-0.16506769,0.07508694,0.012219277,0.10049378,0.1035909,-0.028545339,0.030177133,-0.008679874,0.007410774,0.054055747,-0.044748783,0.051852513,0.0015383859,0.002866781,-0.0037214737,0.0009906797,0.0042152037,-0.06834605,0.05943812,-0.006863443,0.004855908,0.002270866,-0.033348903,0.0026346438,-0.095030874,0.020227512,0.082807995,-3.598816e-05,0.034576856,-0.0354533,0.03732492,-0.0073950477,-0.020294242,-0.03873842,-3.514482e-08,-0.027741985,-0.043412585,0.077484,0.008322666,0.027049916,0.0071879462,-0.010888296,-0.042864475,-0.0077036424,0.03627939,0.036334332,0.10402392,-0.023158245,-0.082354784,0.035168726,0.0058712712,-0.032065272,0.020922763,-0.012727119,0.031403754,-0.04704758,-0.0006026906,-0.09360687,0.0042866208,0.055640124,-0.09077027,-0.0037046948,-0.03828245,0.036449894,-0.06252207,0.019530794,0.028661165,-0.012113396,-0.0341388,-0.16013868,0.008628092,-0.0682405,-0.061712354,-0.045656804,0.029087678,-0.0329485,0.042858217,-0.09189748,0.0043394486,-0.030658808,0.045281224,-0.019497558,0.06821219,-0.046164703,0.007709538,0.02718586,-0.022424424,0.040613145,-0.03879562,-0.036210913,0.07930418,0.05276455,-0.009856901,0.045842983,0.005197906,-0.0035994998,-0.042027052,0.12378848,-0.01909368 +2.7.7.67,"This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1]. ",384,1.0,-0.08762343,-0.05611848,-0.1225191,-0.011347098,0.0016938195,-0.0058815144,-0.090621695,-0.020984681,-0.0037652273,0.015645396,-0.011935868,-0.0026809091,-0.030513464,0.032625347,-0.020412128,-0.01107562,-0.017309744,0.025245521,0.022910295,-0.0070646578,0.1124603,0.035243787,-0.03314326,0.052773844,-0.008178572,0.055163093,0.05415987,-0.116721176,-0.018869078,8.569197e-05,0.035037983,-0.08477437,0.13047412,-0.060649123,0.04567092,0.10132214,-0.025975889,0.0023729573,0.015697937,-0.029092263,0.0564197,-0.020056155,0.07721265,-0.089658186,-0.012509579,-0.016860617,0.044909935,-0.011542775,0.05525127,-0.03172678,-0.043486275,-0.08488083,-0.12168335,-0.037536744,0.023652775,0.052910566,-0.099918544,-0.07548882,-0.01757336,-0.03095939,0.05373076,-0.015873438,0.029467609,0.022616306,0.025871608,-0.09523973,0.053116772,-0.06873898,0.03958146,0.01302108,-0.022896282,-0.051837545,-0.058408607,-0.011536372,-0.05676527,0.04343669,0.0046176654,-0.025606494,0.026634125,-0.059895325,0.040682226,-0.06911257,-0.025913838,0.11214194,0.023009794,-0.026591755,0.042350538,0.005055287,0.05065597,0.04742257,0.0706417,-0.025049705,0.06351138,-0.04916375,-0.046278063,0.016135765,0.0068141874,0.011595119,-0.023894494,-0.0280068,0.02682933,0.043421015,-0.00022563658,-0.09042618,-0.07195123,0.0026862433,-0.027797958,0.058432825,0.043163434,0.0593387,0.0061944,0.0080523575,0.03988241,0.041936014,-0.0152168665,0.08651662,-0.022926506,-0.08240717,-0.085346155,0.08646443,-0.033400048,-0.051050004,0.009180881,0.094199754,-0.053894207,0.10440491,-0.077313475,2.2681505e-33,0.05361956,0.07230461,0.025447858,-0.06293826,-0.02025853,-0.012750951,-0.062259503,-0.022020124,-0.07145119,-0.02264242,-0.06384593,-0.03952607,0.06908347,0.029059988,-0.034498464,-0.0015442087,-0.004034445,0.02957606,0.08862572,0.038848452,-0.034956124,0.022653304,0.009227758,-0.036071066,0.089169994,0.0379138,0.02483353,-0.047193788,0.037355047,0.0057120514,0.05059738,-0.15291627,-0.08322156,0.05692059,0.14046663,-0.013973809,-0.024793245,-0.056923293,-0.031189194,0.04033661,-0.057241354,0.0058856606,-0.032127257,0.018496966,0.00018942321,0.011605959,-0.03172348,0.07479999,0.044003952,0.07155269,0.0034891886,0.033989355,0.0692685,0.023657825,-0.10339182,0.00695861,0.0063145463,0.051322117,0.023103695,-0.01146082,-0.01510052,0.07841199,-0.026099866,0.0011291414,0.060675103,0.03048581,-0.06331699,-0.011088923,0.01778907,0.041146718,0.018066412,-0.02517144,0.047994915,0.053792316,0.0005366768,-0.015633008,0.0138396695,0.023285745,0.012657756,0.029871775,-0.06905275,0.008083723,0.031281453,-0.055123307,-0.024158973,0.023553235,-0.033549633,-0.06438313,-0.024197694,0.0700646,0.0007077559,-0.02534117,-0.015366239,0.07096536,-0.062523365,-3.839747e-33,-0.0017311095,-0.12823685,0.008139052,-0.07285949,-0.09192297,0.07984481,-0.027157845,-0.01826699,0.06030181,-0.024274204,0.06808693,-0.0090001635,0.06607005,-0.07305739,0.027047582,-0.029732773,0.013344816,0.057359923,0.016721142,-0.03283735,0.07323471,0.03006516,-0.018271301,0.08066519,0.01949251,0.019933468,0.022821175,0.079283856,0.0065941145,0.066703625,0.046741746,0.046297517,-0.081179924,-0.05088232,-0.113730736,0.07252941,-0.044278145,0.021672837,0.06076059,0.006407219,0.007255024,0.07220504,0.08918962,0.05038407,0.033402286,-0.016145008,-0.024926383,0.08252422,0.016766435,-0.12128519,-0.0135517055,-0.03872272,0.01800136,0.026052285,0.05609402,0.014681709,0.016170897,0.07686184,0.00091126625,-0.091211,-0.051863134,-0.07286698,0.038085356,-0.023959806,0.016169205,0.07091336,0.009673661,-0.05521591,0.011779029,0.007092766,0.030885674,-0.010827336,0.0004454335,0.072929986,0.022612182,0.045317754,-0.022114247,-0.058586754,0.0075526093,-0.06596174,0.041637734,0.06256658,-0.00084496377,-0.1049485,0.027018558,-0.08294861,0.07783448,0.11565204,0.00832175,0.015426029,-0.013567831,-0.037660636,-0.09250261,-0.022612104,0.051891662,-3.6754788e-08,0.027566088,-0.08344607,0.047047734,-0.04664096,-0.0061753686,0.06016209,0.061687928,-0.0051452937,0.04567008,-0.09753022,0.01771036,0.021453975,0.029996175,-0.024090383,0.041230243,0.05556745,-0.0299991,0.029861318,-0.03663626,-0.06578973,-0.02712822,-0.045599893,-0.09191009,0.030540556,0.0032041734,-0.044324026,0.024536539,-0.0005107027,-0.05353712,-0.026915696,-0.0065042605,-0.01812402,-0.03627268,0.015341739,-0.013349536,-0.0067557986,-0.04786303,-0.0104586175,-0.0038466884,0.020516507,-0.050123047,0.01080337,-0.043452837,0.0060320995,-0.058081448,0.022081476,-0.008361219,0.07245203,-0.071535766,0.057596717,0.021624196,-0.02430508,-0.022296906,-0.103573315,-0.07464741,-0.038255066,0.02614447,-0.08235246,-0.069681935,0.0019054937,0.05044263,0.00027580594,0.09321976,-0.023672098 +2.7.8.41,The eukaryotic enzyme is involved in the biosynthesis of the mitochondrial phospholipid cardiolipin. It requires divalent cations for activity.,384,1.0,-0.04149723,0.028162569,-0.10908553,0.040246572,0.02299221,-0.0019867232,-0.049569167,0.013452163,0.039051384,-0.044859562,0.0347286,-0.07982291,-0.13381223,0.06088822,-0.010587805,-0.031573083,-0.111993276,0.019633029,-0.009959711,0.027485486,0.05450363,0.033817507,-0.007407773,0.06281594,-0.037789673,-0.038646203,0.061779402,-0.058360703,-0.017473692,-0.0127470605,-0.06492169,-0.027483739,0.08097163,-0.011227955,-0.00723395,0.10387744,0.024077944,-0.06067783,-0.026729412,-0.03798799,0.08474014,-0.028172068,0.020291485,0.02706778,-0.017693594,0.02548966,0.003096967,-0.00076114957,-0.009609928,0.0010376725,-0.017584719,-0.018799512,-0.060251404,-0.005588672,0.006272407,0.032681696,-0.04418173,-0.06779837,-0.004800143,-0.040271945,-0.010800428,0.024694443,0.013693538,0.053131584,-0.015441349,-0.11550894,0.06187306,-0.046429303,-0.0036110517,-0.03502396,0.067161925,-0.0781396,0.003714456,0.033786334,-0.003279803,0.10150211,-0.023202062,-0.0391695,0.015261195,-0.018751284,0.05662534,-0.042674758,-0.010875489,0.12331866,-0.0013342266,-0.015545773,0.021923497,-0.036964834,-0.012126358,0.040598974,0.07913551,-0.013746439,0.00018066268,0.011615545,-0.13718317,0.008826347,0.057971258,0.02411131,-0.0124509735,-0.027286442,0.036907524,0.0971598,-0.0065870807,-0.028580569,0.0076413355,-0.025165,0.051176235,0.034706026,-0.00078324694,0.018620487,0.080678016,-0.057870638,0.030595073,-0.04961736,0.034746114,0.09243271,0.034959797,-0.074457996,-0.010435742,0.10479548,0.00026739322,0.006821732,0.009788955,0.09050587,-0.07610088,0.040526543,-0.08420611,1.346807e-33,0.04196711,-0.025579236,0.007701509,0.018738104,-0.023344144,-0.030736841,-0.12069138,-0.08565797,-0.039285194,-0.06574626,-0.07738064,-0.007450577,0.03688055,0.028601568,0.0111256745,-0.025667196,-0.021529758,0.015475202,0.13002332,0.04333302,0.013138142,-0.015228681,-0.006556741,-0.02821433,0.045500796,0.07442219,-0.042678867,-0.021459518,0.08142419,0.0132535845,0.054214243,-0.13665184,-0.10072217,0.02921364,-0.010122648,0.011942745,-0.021118844,-0.03840549,-0.009662755,0.017665105,-0.014894378,-0.03810713,-0.023684844,-0.10710128,0.08564335,-0.056412917,-0.008050811,0.03251825,-0.01761048,0.03459909,0.04467619,-0.05385455,0.15485147,0.002063474,-0.034761615,0.022907788,0.0071864333,-0.020174237,0.043160114,0.055607103,0.0040588393,0.048607346,-0.030872667,0.043239843,0.054942477,0.030373804,-0.01302477,-0.07562338,-0.112318754,0.03106929,-0.030997453,-0.05698166,0.067178324,-0.01128215,-0.012323294,0.043542564,-0.006356158,0.03506495,-0.10020567,0.049527522,-0.025617212,0.0012303991,-0.021517467,-0.009836583,-0.0011048935,0.029719623,0.010847857,0.008752803,-0.036014758,0.056949854,0.016425664,0.01219541,-0.047215976,0.010980326,-0.0093539525,-3.2394637e-33,0.07416397,-0.13019723,0.048033804,-0.14979862,-0.05188372,0.09032296,-0.040594887,-0.03323727,0.075190015,-0.03916575,-0.02976577,-0.028289728,0.0076080444,0.004295019,-0.0059980014,0.07273184,-0.05457631,0.09476358,0.050498504,0.009429905,-0.03704877,0.09447283,-0.013521644,0.11187861,0.058487717,-0.010471167,-0.0064662327,0.030509448,-0.018139362,-0.04268697,-0.019067146,-0.08082627,-0.06282633,-0.022279482,-0.07511347,0.05992061,-0.026341818,0.07713769,0.10994204,0.03587068,-0.027332017,0.043509807,0.007162879,-0.0409143,0.015774895,0.019919107,-0.040134918,0.017656995,-0.018529942,-0.05417968,0.0021054298,0.0052690115,-0.00093924603,0.048009478,0.002390332,0.060738545,0.05001704,0.06263114,0.05941333,-0.062475502,-0.06560101,-0.0865279,0.056443464,-0.024417046,0.0061283745,0.07677632,-0.06308546,-0.03973055,-0.020689568,-0.022069758,0.045484703,0.10214509,-0.03739338,0.05182846,0.0032505977,0.03061006,-0.0067203664,-0.09695088,0.027008131,-0.08774019,0.019795349,-0.02928475,0.026897456,-0.091679215,-0.04882236,-0.05128359,0.06965831,0.0399802,-0.012974917,-0.012355174,0.018976457,-0.06313574,-0.031131715,0.027567282,0.024542559,-2.8878503e-08,0.029307175,0.0028006064,0.0036273708,-0.06157766,-0.017420724,0.017787494,0.09393021,-0.014502452,0.025207441,-0.025018474,0.013276417,0.07151907,0.03247513,0.019497946,0.063613325,0.04629827,-0.049161535,-0.013966108,-0.0062796725,0.018529348,0.062076252,-0.003638837,-0.05044066,0.05944917,-0.00835009,-0.049465217,0.04045949,-0.020159898,-0.015879638,-0.04941472,0.0307175,0.013546145,-0.023252847,-0.02091382,-0.0042942525,0.021345511,-0.032982018,-0.10633165,-0.03873948,0.04692738,-0.020673538,-0.047029734,-0.079247214,-0.034629628,-0.04948008,-0.0067977034,0.046457604,0.04886397,0.0077739665,0.016673286,0.055813376,0.016288066,-0.01665638,-0.04458578,-0.11342751,-0.013812917,0.037223946,-0.048288472,-0.018608375,0.010098065,0.067297794,0.0725909,0.19275531,-0.03387867 +4.2.1.114,"This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea. Requires a [4Fe-4S] cluster for activity. In contrast to EC 4.2.1.36, homoaconitate hydratase, this enzyme can catalyse both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate. In addition to cis-homoaconitate, the enzyme can also catalyse the hydration of the physiological substrates dihomoaconitate and trihomoaconitate as well as the non-physiological substrate tetrahomoaconitate. cis-Aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme.",384,0.99999994,-0.047461774,-0.024738591,-0.08746642,-0.009575471,0.065374605,0.016186021,-0.12074458,-0.02918931,0.011469714,-0.045721702,-0.075373776,-0.1485291,-0.008949143,0.004318826,-0.04139976,0.008316047,-0.06503302,0.024711732,0.010549837,-0.04162657,0.08501096,0.005736933,-0.015345275,3.83432e-05,-0.04855368,0.037559193,0.07312518,-0.057101127,-0.01409172,-0.014882301,-0.023605375,-0.068672106,0.06309104,-0.096775316,0.032125004,0.10943883,-0.027303053,-0.111880735,0.038653497,-0.009335411,0.035377316,0.030093405,0.03535504,-0.00769206,0.003969091,-0.007986046,0.00891873,-0.014586686,-0.026735725,-0.05830753,-0.056127727,-0.05526784,-0.05785551,0.050234087,-0.0072532063,0.0767824,-0.04007865,-0.046447173,0.022478543,-0.08280085,0.093095295,-0.004073231,0.019076947,-0.044209447,0.05008673,0.018244097,0.05267864,-0.00844055,0.12075038,-0.015659522,-0.09324688,0.024854334,-0.022366023,-0.023822095,-0.01560847,-0.0071369433,-0.015934879,0.015933637,0.035176158,-0.050275527,0.01538597,0.0012713101,0.016321203,0.011118797,0.039061047,-0.026644168,0.018735345,-0.020706639,0.06220273,-0.018635495,0.041358087,0.048255097,-0.020290596,-0.076392636,-0.13542275,-0.011017499,0.027490389,0.054237682,0.028036578,-0.036277257,0.015244343,0.059870336,-0.072989024,-0.01265586,-0.030312762,0.0033161696,-0.006407205,0.15680243,0.08434675,0.09976901,-0.01628993,-0.044434685,0.07694831,0.08058682,-0.03519783,0.10748625,-0.070913814,-0.06439469,-0.0341182,0.059902105,0.0059705786,-0.021912167,0.08912212,-0.020184426,0.009295436,0.016695889,-0.12785962,4.003438e-33,0.08783243,-0.0064490186,0.0007759703,0.006569286,0.037212342,-0.022970531,-0.097190216,0.031081825,-0.056477275,-0.026348988,-0.04457944,-0.062736705,0.0856896,0.0017506744,-0.05485831,-0.061056286,-0.003053509,-0.015689353,0.008661363,0.0644837,-0.019119015,0.082843065,-0.010938422,0.012162305,-0.008532009,-0.026153632,0.019062096,0.027545437,0.062289067,0.027794095,-0.03746552,-0.09428879,-0.09651459,-0.0030016415,0.09761212,0.039612386,-0.025915025,-0.0008295752,-0.07782691,0.09562838,0.005986177,-0.0010519248,-0.0127570545,-0.05077681,0.09810693,0.011485966,-0.0028296837,0.11837161,0.0037940221,0.016462857,-0.024002105,-0.011170394,0.042083442,0.011019928,-0.09793472,-0.012738837,-0.044945017,-0.030514892,0.049201902,0.021898255,-0.007643176,0.040439084,-0.022073356,0.03554559,-0.035981223,0.057367075,-0.05748032,-0.010884642,0.059443537,0.07013084,-0.017175455,-0.0009602333,0.03499615,0.05385834,0.003917393,-0.029188668,-0.023404451,-0.04174887,0.02898428,-4.9872315e-06,-0.016607644,-0.007615056,0.0635603,-0.0019579849,0.0009877542,-0.045253497,0.0019873162,0.0014625737,0.029860144,0.029037163,0.029594542,-0.04426351,-0.019534891,-0.01449634,0.03553896,-4.247375e-33,0.14810793,-0.088474624,0.0024375056,-0.094126105,-0.057629507,0.085726075,0.026757598,-0.075468615,0.05947888,-0.07433688,0.1473162,0.006817423,0.022230877,-0.044494357,0.036574677,0.008157161,-0.009934247,0.03445925,0.014813583,0.03860298,0.05907563,-0.014545386,-0.04056627,-0.008694445,0.031411573,0.004458471,0.039300144,0.06390147,0.07163295,0.045830645,0.028193874,-0.020753633,-0.07333767,-0.0099929385,-0.06648901,0.053553034,-0.05833136,0.0039954386,0.047332726,0.055627234,0.055539988,0.01872918,0.020779826,0.014155495,0.07026411,0.0049999794,-0.120568864,-0.029134136,-0.01904776,-0.03786424,0.048749007,-0.084556155,-0.05577253,-0.02831793,0.0124381585,0.04523707,-0.0010265829,0.02529301,-0.018714236,0.0026411426,-0.0227292,-0.04291741,0.07294375,-0.016786458,0.017667616,0.02717225,-0.007096089,0.055152506,0.054102518,0.003809181,0.019245273,-0.0024166657,0.026917774,0.05639476,0.03208096,-0.038211994,-0.0885249,-0.053525884,-0.01428611,-0.075302646,-0.039583392,0.022890758,0.045821097,-0.10055833,-0.04414049,-0.07736716,0.051660933,0.060000673,0.012540041,0.02845992,-0.011390043,-0.08552392,-0.018351294,0.050498668,0.103399225,-4.5898602e-08,-0.0033012654,-0.029988684,0.012086712,0.031028654,-0.003456546,0.071261585,0.025015773,-0.073510654,0.05798542,-0.07349701,-0.020391338,-0.0402807,0.040193994,-0.0036050426,0.014876379,0.037595764,-0.015790537,-0.024436515,-0.059088033,-0.038602017,-0.062698714,-0.045685235,-0.056246657,0.009558092,0.033762254,-0.058625657,0.043265138,0.02573458,-0.033103436,-0.09778825,-0.057642046,0.038359813,0.023834703,-0.008079685,-0.013461094,0.006432565,-0.00075227703,-0.006943233,-0.048294187,0.026565546,0.047705773,-0.013961639,-0.10049822,0.008539275,0.10661977,0.026150912,0.0066862507,0.07142094,-0.04862635,0.055209752,0.037645616,0.038796343,0.027389595,0.019244378,-0.033605807,0.023840312,-0.033115365,-0.03802488,-0.082491875,-0.011932563,0.09467564,-0.0014706069,0.13399546,-0.10272096 +4.2.1.115,"Contains NADP+ as a cofactor. This is the first enzyme in the biosynthetic pathway of pseudaminic acid [3], a sialic-acid-like sugar that is unique to bacteria and is used by Helicobacter pylori to modify its flagellin. This enzyme plays a critical role in H. pylori's pathogenesis, being involved in the synthesis of both functional flagella and lipopolysaccharides [1,2]. It is completely inhibited by UDP-alpha-D-galactose. The reaction results in the chirality of the C-5 atom being inverted. It is thought that Lys-133 acts sequentially as a catalytic acid, protonating the C-6 hydroxy group and as a catalytic base, abstracting the C-5 proton, resulting in the elimination of water. This enzyme belongs to the short-chain dehydrogenase/reductase family of enzymes. ",384,0.9999999,-0.04643594,-0.088293694,-0.14782919,-0.01779628,0.04520327,0.06163429,-0.08717401,0.052688114,-0.009525146,0.007912303,0.064205416,0.03620801,-0.1408244,0.06137556,-0.010809181,0.04361834,-0.122711025,-0.04533122,0.010914373,-0.035114575,0.015979832,-0.0065706912,0.024056872,-0.004944118,0.026267739,0.029298062,0.05821595,-0.0036998081,-0.05673679,-0.06598116,0.020789385,0.0023572766,0.014139502,-0.08384234,0.06709885,0.050743796,-0.06409767,-0.07591048,0.11553724,-0.019437896,0.0017469542,-0.042848587,-0.040759303,0.040288474,-0.06097281,-0.019777719,-0.060548257,0.08832565,0.04416162,-0.048753988,-0.006206929,0.02070902,-0.010140888,-0.013117454,-0.077143066,0.012671347,-0.024788992,-0.039927855,0.052042007,-0.034377128,-0.0076415488,0.038398553,0.02509874,0.021399632,-0.0033716466,-0.06023759,-0.00428208,-0.09586939,0.039931238,0.0015901489,-0.07352997,-0.058960322,-0.003461481,0.01600029,-0.03717466,0.059709348,-0.009310297,-0.0392475,0.023857288,-0.021417474,0.052823335,0.0062231314,0.022198342,0.12736599,0.04886051,-0.075936824,0.029773034,0.03179993,0.0045281984,-0.0062993392,0.034997366,-0.06021597,0.021628458,0.00811201,-0.109413914,0.030389586,0.032865196,-0.054347876,0.03877445,-0.015326155,0.0085389465,0.058816,-0.012670915,-0.04709487,-0.04897614,0.07879062,-0.024602417,0.08711883,0.018042339,0.0040800255,0.0146712,0.033878207,0.024389774,-0.0734104,0.0019824856,0.09566566,-0.014545432,-0.015638072,-0.04816011,-0.012692081,0.03636923,-0.07657527,0.040593773,0.0071565607,0.010448162,0.023891758,-0.15885065,1.52442075e-33,0.10577386,0.041066486,0.031746503,-0.06531501,0.023132103,-0.038130697,-0.09620151,-0.03672077,-0.047136284,0.034314808,-0.06110152,-0.11433086,0.039926644,-0.0033909508,-0.0924489,0.07124235,0.00036698143,-0.05684424,-0.0020213877,0.029628042,-0.02345191,0.07980176,0.016903687,-0.07324839,0.08242684,0.08231931,-0.038869586,0.08940451,0.012200365,0.018670946,0.015036236,-0.06549841,-0.080328956,0.060308944,0.07124233,-0.0059450096,-0.05963422,-0.0900934,0.06774928,0.012768655,0.035874326,0.080242574,-0.04570313,-0.06261345,0.050152842,-0.023168882,0.03127354,0.08729941,0.020387568,0.026172318,0.06388168,-0.03743062,0.07045119,0.012732797,0.03130189,-0.01080274,0.044527415,0.0010871683,0.029675644,0.06720695,0.06735052,0.04901853,-0.014829649,0.027035046,0.03232293,0.022544738,-0.02854961,-0.029987408,0.013954914,-0.009457585,-0.092376634,0.0024629098,0.04801076,0.0034179112,-0.020110175,-0.0345644,-0.022424888,0.04570597,0.018971052,0.03845861,0.009587944,-0.010025285,-0.011892191,0.021638459,-0.027707811,0.063718654,-0.092022575,-0.038236607,-0.013704575,0.009853438,0.03070018,-0.06512695,0.055545673,0.046371475,-0.030629909,-3.7073824e-33,0.028754681,-0.091598615,0.04233288,-0.10606651,-0.05425283,0.05692042,0.063041605,-0.05242567,0.0039908313,-0.007196845,0.0812587,0.041254908,0.018525645,-0.05407322,0.041630495,0.06470981,0.0023769976,0.13371085,-0.06094002,-0.020254057,0.021520222,0.13337207,-0.023439271,0.025895571,0.0047467425,-0.0065711094,0.008944062,-0.006481026,0.036381558,0.023604032,0.007840268,0.010231222,-0.063193396,-0.11217486,0.049716573,-0.03217273,-0.08863393,0.0030515094,0.037937667,0.019603064,-0.016249936,0.038110945,0.04836046,-0.012121922,0.056019988,0.0137361055,-0.0589762,-0.0773854,-0.007725862,-0.00629773,-0.019103631,-0.04559372,-0.004761587,0.059848834,0.040292364,0.06523797,0.038726848,0.020935422,-0.0013007789,-0.0049701734,-0.040811114,-0.071747005,0.08485151,0.01794585,0.032218583,0.039644923,-0.060562484,0.032485675,0.073999465,-0.08094755,-0.0063702967,0.04294542,-0.021917766,0.113708325,-0.012380554,-0.0056291115,-0.10191769,-0.039222732,0.012788362,0.020875305,-0.009812176,-0.051102925,-0.08047633,-0.052984323,-0.00064614706,-0.049555384,0.0011313636,0.066862024,0.028734168,0.04435867,0.02606507,0.0006394908,0.01165595,0.015384766,0.079345785,-4.771597e-08,0.015179883,-0.101604916,0.06454739,-0.03554947,-0.012139052,0.044194393,0.027459448,-0.029156039,0.033499856,-0.05025876,0.02493396,0.13264085,0.029722635,-0.04227093,-0.052557915,0.014663942,-0.012106027,-0.014247154,-0.032465342,0.010285035,-0.01529017,-0.032283485,-0.03523662,0.036358397,0.01695542,-0.10318221,0.039839797,0.031966947,-0.01928801,-0.070330426,-0.013737496,0.039998926,0.002161884,-0.056634296,-0.055099957,0.023892604,0.025462693,-0.0566555,0.0071279667,0.047140222,0.012114508,-0.00317909,-0.13123627,0.019010749,0.01657827,0.03431066,-0.057510905,0.008939857,-0.07559021,0.018502198,0.019204464,0.038546104,-0.047960773,-0.0609372,-0.043157186,0.055851992,-0.03312104,0.0070008715,-0.00023651548,-0.05074651,0.03363131,-0.022820376,0.13294905,-0.07144303 +4.2.3.38,"This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding.",384,0.99999994,-0.028796185,-0.006021149,0.0008921324,-0.0019339452,0.04915087,-0.021036435,-0.023051245,0.064926125,0.03855441,0.016318414,0.03240166,-0.0117953075,-0.022601932,-0.0036390033,-0.085409164,-0.03657178,-0.030796342,0.003786149,-0.0059139077,-0.014691633,0.09254163,0.0154936975,-0.022331733,0.0038597425,0.01667521,-0.06532888,0.00076512806,-0.0035416498,0.03887726,-0.024517149,-0.07750976,0.033916935,0.061077915,0.006974309,-0.026048953,0.033922397,0.03638287,-0.060400918,0.027545702,0.053711627,0.1420474,0.0079979375,-0.011381732,-0.08972228,-0.059005063,-0.016088761,0.06755593,-0.084976174,0.03913972,0.0019266189,-0.010346638,-0.055585593,0.0010560419,0.0017997996,0.015724543,-0.05349521,0.033273146,-0.013819465,-0.031163545,0.04129056,-0.0040331953,0.010933964,-0.039433185,-0.047001455,0.0047251782,-0.048084915,0.009472672,0.007965441,-0.03726855,-0.001501804,0.005054207,-0.03467282,-0.073415846,-0.056780085,-0.07979574,0.13911165,0.02220014,0.006234498,0.01200871,-0.026066275,0.069298744,0.045987234,0.045124047,0.02153659,-0.021627428,0.047374394,0.03656501,0.051330216,0.040015113,0.019324958,0.063754275,0.018451266,-0.012992489,-0.0146662565,-0.07986502,0.1260015,0.041942015,-0.07331261,-0.005975544,-0.032962527,0.00060194614,0.0567866,-0.030279629,-0.066039175,-0.06287545,0.038004465,-0.0323576,0.032273717,0.03592141,0.0131251635,0.053375967,0.012980679,0.044571027,0.0396347,-0.10038616,0.05321398,-0.023929805,-0.03921908,-0.052898303,-0.0017624327,0.052990668,0.015794935,-0.027593466,0.04789146,0.029518256,0.011414094,-0.05427938,7.855842e-35,0.07120367,0.07716924,0.0041086557,-0.018149316,-0.029560113,-0.006790996,-0.101321585,0.07151202,-0.060609933,-0.022396043,-0.066532396,-0.08959666,0.052452534,-0.00020236515,-0.034225732,0.04623872,-0.035403695,-0.013399526,0.10124971,-0.05396233,-0.053210653,-0.045303077,-0.052829392,-0.0767926,0.0007643076,0.09197798,-0.026346404,-0.051552854,0.0757292,-0.0344146,0.011779262,-0.09972661,-0.018196953,-0.0076241605,0.043521076,-0.054961286,-0.026977878,-0.07105161,-0.087159105,-0.0012863092,-0.04094792,0.033566996,-0.033301253,-0.01447627,0.06212188,-0.088885896,-0.043333966,0.038731404,0.03793629,0.04144623,0.013669809,-0.011157127,0.119319126,0.0030795296,-0.086258456,0.050970897,-0.06976705,-0.09057265,0.015214667,0.042994034,0.07572452,0.0006752711,-0.038040545,0.013020062,0.019297983,0.082292944,-0.15040015,-0.05341543,0.02253198,0.13541208,0.00090790156,-0.11480856,-0.0075443094,0.01594009,-0.017231347,0.04144052,0.041392934,0.05942727,0.05499627,0.06508242,0.004700143,0.009778297,-0.018392919,-0.0020918224,-0.040076602,-0.022521373,-0.010131128,0.025232306,0.026437555,0.0525913,0.030918809,-0.084145695,-0.068788186,-0.009638925,-0.0373987,-1.1170396e-33,0.09038852,-0.04821568,0.012400102,-0.08777095,-0.031164138,0.023994988,-0.008541126,-0.0022964305,-0.032317217,-0.03139916,0.02053842,0.01246257,0.034786344,-0.013756131,-0.043650135,-0.003086722,-0.043057825,0.098029874,-0.030158069,-0.009297432,-0.018235479,0.10345128,0.08242173,0.075345,0.042262133,-0.054258972,-0.0220757,0.013223778,-0.04574244,0.11020024,0.09222274,-0.040485892,-0.058291085,-0.024419922,-0.026722664,0.061284494,0.014689339,-0.0016662449,0.07747454,0.0315429,-0.061672416,0.004853257,0.09540139,0.10744803,0.122769676,0.01575776,-0.10484074,0.05525523,0.011371848,-0.03441307,-0.014904404,0.05474995,-0.038466536,-0.010460908,0.043455306,-0.06549293,0.06605214,-0.03454583,-0.04858286,-0.09706299,-0.04127582,-0.05876225,-0.02488149,-0.041027177,0.047709964,0.08002922,0.041299477,0.06957588,0.053007092,-0.024828525,0.060887463,0.03163737,0.022814006,-0.013998541,-0.05551039,0.058025308,-0.017510716,-0.07209733,0.0018440376,0.010570393,-0.00015854966,0.014208267,-0.048093453,-0.058596272,-0.047502268,-0.043608893,0.049923096,0.1276741,0.0029123176,-0.023860423,-0.094129555,-0.0213821,0.0046498654,0.096018866,0.053029433,-4.373732e-08,-0.015083302,0.062860675,0.008574165,0.0077480027,-0.06495963,0.002342607,-0.037317846,-0.0025454725,0.03398903,0.011560199,-0.053506862,-0.0043702293,0.006951386,0.059583724,0.07735747,-0.0068840077,0.028251674,0.03252208,-0.05215198,-0.040137686,0.008371752,-0.032302946,-0.104761906,0.0716545,0.008438434,-0.15025903,0.037038144,0.019080412,-0.03835623,-0.027591366,0.07097816,0.030022813,0.0040749386,0.061164603,-0.029570583,0.019894168,-0.025397528,0.03609943,0.0174532,-0.0066329595,-0.029505093,-0.06845157,-0.05788259,-0.031949695,-0.07564656,-0.0018097253,0.05887551,0.014820431,0.021357387,0.049740776,0.096250296,-0.02118002,0.03397721,0.010805032,-0.011923158,-0.08097657,0.0009261017,0.015303542,0.057262223,-0.048767116,-0.0015884923,0.021290142,0.14254226,-0.012244125 +4.2.3.39,"The enzyme is activated by Mg2+ [2]. Similar to many other plant terpenoid synthases, this enzyme produces many products from a single substrate. The predominant product is the cyclic sesquiterpenoid alcohol, 8-epi-cedrol, with minor products including cedrol and the olefins alpha-cedrene, beta-cedrene, (E)-beta-farnesene and (E)-alpha-bisabolene [1].",384,1.0,-0.02310842,-0.061558384,-0.023971079,0.022179648,0.073073745,0.018766131,-0.02048288,0.05316722,0.059784956,-0.031594645,0.061923828,-0.04223117,0.016663736,-0.060768455,-0.022611557,-0.003439477,-0.031274404,0.05001431,0.028226715,-0.062340632,0.09863967,0.004767356,0.025542835,0.027169732,0.028417453,0.03562557,0.04209903,-0.0023178295,0.052440412,-0.07580653,0.0029303157,0.045360558,0.071425214,-0.0328789,-0.015253651,0.012597316,-0.047040366,-0.058293555,-0.00864514,-0.022039685,0.10051652,-0.077026874,0.0191536,-0.098519534,-0.051199112,-0.057643127,-0.017012274,0.038329788,0.030629328,0.016472856,0.022553252,-0.09972444,-0.026164683,0.012962616,0.005887405,-0.034132607,0.0061440985,0.012045531,-0.026870454,0.06756216,0.09074369,0.015601038,-0.050186675,0.004209557,-0.012045872,0.023612656,-0.051539622,-0.060430385,0.0139442105,-0.05458989,-0.06280558,-0.07903506,0.022452265,0.04747822,-0.066047534,0.024212632,0.04054259,-0.048222218,0.047320224,-0.01778571,0.011788644,-0.0010049344,0.04926973,0.052315343,0.07021987,0.05688569,0.03131678,0.07065243,0.06252845,0.09775127,0.10687902,0.06703022,-0.07919536,-0.008756133,-0.05316395,0.08291812,-0.0047141565,-0.0010253459,0.0063478225,-0.020253105,-0.014935074,0.06262749,-0.038656004,-0.08259587,-0.09211804,0.040583678,-0.02048494,-0.0741877,-0.0064698923,-0.02584954,0.017887026,-0.058270425,-0.0010066124,-0.00446151,-0.0612297,0.099005535,-0.010092192,-0.07700507,0.0056161294,-0.048398893,-0.0046800757,0.008936888,0.0076923827,0.10791058,-0.054111473,0.04784638,-0.022694133,2.3645218e-34,0.018524349,0.07549153,-0.05238872,0.03229477,-0.060268767,0.015367258,-0.04181982,0.09976205,-0.06267627,-0.06009738,-0.08468047,-0.035590112,0.00598601,0.018962316,0.04502442,-0.109772496,0.0791985,0.045069307,0.11303882,-0.036538586,-0.012033533,0.04497797,-0.05731865,-0.009706523,0.022368498,0.05442856,0.020069629,-0.0063238065,0.074656956,-0.017373273,0.006127927,-0.0793702,-0.038302913,-0.025425551,0.058730517,-0.0018231068,0.00013342258,0.0046913493,-0.07436602,0.0796264,-0.023961173,0.012934348,0.016805997,0.03124157,0.033719398,-0.08372317,-0.08728826,0.0049436227,0.11549877,-0.01573611,0.039193906,0.01217221,0.043195393,-0.014493051,-0.07854227,0.03805986,-0.059577737,-0.012701311,0.011044957,0.010973307,-0.033124853,0.05596443,-0.06340036,-0.017166585,0.024578651,0.107821144,-0.06037147,-0.08081157,-0.04568009,0.07513376,-0.043716125,-0.039834276,0.09314397,-0.028454604,0.04375021,0.06434159,-0.063643634,0.020282906,0.03528019,0.024784511,-0.05196492,-0.009448785,-0.022747414,-0.043113455,-0.0255649,-0.042964313,-0.07375185,0.009785707,0.0008329424,0.0414496,0.08417837,-0.06954648,-0.012541605,0.05848285,-0.011613002,-1.6124432e-33,0.039599106,-0.089929685,0.058111917,-0.09682803,-0.051460497,0.061153505,-0.027406588,-0.075116016,0.01750277,0.039841987,0.065927565,-0.020628344,0.066775136,-0.07849045,-0.018072106,-0.035844207,0.0010032556,0.12242823,-0.04080767,-0.042628214,0.03583707,0.08527362,0.08761121,0.04545145,0.02087993,-2.6967304e-05,0.05967285,0.056109987,0.018857865,0.08126053,0.049448308,-0.05284221,0.01663369,0.042380236,-0.04683931,0.09752397,-0.02862655,-0.013978785,0.027127491,0.08226329,-0.026033655,-0.008155067,-0.016577313,0.06853234,0.08923827,0.007679737,-0.086982094,0.026646936,-0.011395725,-0.05356201,0.034934398,0.02701343,-0.0664588,-0.03577085,-0.0047142603,0.013765407,-0.02809404,-0.020245126,0.0044117775,-0.047302365,0.011545261,-0.033965748,0.015441049,-0.032880075,0.018278709,0.041162122,-0.05404869,0.032242198,0.0033851883,0.028426476,0.06668228,0.032888103,-0.04259573,0.032687236,-0.03218038,0.0051617096,0.032450162,-0.10617707,-0.01164149,-0.081324905,-0.02533227,0.005257466,0.015911883,-0.04614089,-0.061412964,-0.0611847,0.0209763,0.071025595,0.056048974,0.046111435,-0.065714754,-0.0020211912,-0.07649657,0.089284696,0.079801954,-4.198932e-08,-0.053809207,-0.045915257,0.041580733,-0.027745072,0.031518396,-0.0018366806,-0.0021605026,-0.074418925,0.07806148,-0.06462184,-0.060474325,0.026663855,-0.034953836,0.020554263,0.11011399,0.0013624162,-0.0027179348,0.007869368,-0.0032742727,-0.011990639,0.048973825,-0.0366127,-0.040137183,0.015413953,-0.021277722,-0.12805025,-0.030138193,0.07334155,-0.016339174,0.023689114,0.029270938,-0.0068086465,-0.019225514,0.032565247,-0.0073201596,0.07282223,-0.050021593,-0.018646656,-0.08987041,0.045775466,-0.024278335,-0.09296734,-0.017987462,0.0012171996,-0.058074005,0.010010515,0.046127707,-0.027956871,0.019297149,0.03338797,0.009348908,-0.058352854,-0.024353174,-0.025465222,-0.065750584,-0.057018474,0.0021263736,-0.047109835,-0.020643387,-0.09456471,-0.0058475235,0.015458197,0.2055163,0.0023427026 +4.2.3.40,"This sesquiterpenoid enzyme is constitutively expressed in the root, hydathodes and stigma of the plant Arabidopsis thaliana. If the leaves of the plant are wounded, e.g. by cutting, the enzyme is also induced close to the wound site. The sesquiterpenoids (E)-nerolidol and alpha-bisabolol are also produced by this enzyme as minor products.",384,1.0,0.012058751,-0.012201176,-0.053050604,0.027109206,0.036124647,0.032146644,-0.027881552,0.07978303,0.09817858,-0.015350604,0.105385534,-0.03399687,-0.011676269,-0.05803933,-0.025788499,0.00094008114,-0.051976625,0.039507937,-0.03719357,-0.12391665,0.05413137,0.06356876,-0.03714932,0.037912533,0.07230516,-0.041111946,-0.026143845,0.039775882,0.0515548,-0.07484023,-0.025544683,0.022930976,0.09003702,-0.019391416,0.008470538,0.04397611,-0.06122723,-0.07860586,0.04858258,0.026770884,0.07253845,-0.03305336,-0.030253852,-0.030405266,-0.09869908,-0.053666826,0.019041095,0.022684747,-0.013843194,0.023951754,-0.00056679884,-0.038412858,-0.070792906,0.041860852,-0.039421137,-0.04383238,0.03345624,-0.01202057,-0.012516275,0.048484214,0.061834026,-0.0025957006,0.049292624,0.01141673,-0.04117157,-0.046932045,0.029132795,-0.048783746,0.0254412,-0.05012252,-0.04433361,-0.05358472,-0.014774783,0.014445429,-0.07832544,0.016923111,0.012792847,0.0027378676,0.027562505,0.002880428,0.019108912,0.00611083,0.013858245,0.08834675,-0.0009275446,0.06836562,-0.032075383,-0.0038757313,0.042954177,0.041934375,0.05554583,0.02361793,-0.015340538,-0.06459437,-0.057259705,0.09426212,0.009029374,-0.002156809,-0.06975643,-0.022840021,-0.007476789,0.020393616,-0.11808171,-0.07950752,-0.03714054,0.041328095,-0.075894915,-0.09722842,-0.0036145274,-0.041255876,-0.010904335,-0.034336075,0.010059587,-0.00028060132,-0.009922999,0.06823428,0.02025909,-0.020805933,0.025987102,-0.026504045,-0.0061809504,-0.01080816,0.009130597,0.018365087,0.015032804,-0.006955213,-0.0744807,1.8304372e-33,0.080387935,0.081753135,-0.07039022,-0.0005123744,-0.070563026,-0.036436733,-0.05350277,0.12612525,-0.10171072,-0.05766872,-0.11323508,-0.102730796,0.03507761,0.012389967,0.008335289,-0.010790272,-0.020075249,-0.007169708,0.052010566,-0.010663257,-0.0057569304,-0.01656585,-0.071226336,-0.0026972238,-0.009704003,0.0004618848,-0.014483478,-0.022280158,0.051833447,-0.018146265,0.011898812,-0.062007707,-0.012117899,-0.013812139,0.058435626,-0.028570049,0.016522063,0.017671987,-0.12064763,-0.0063830847,-0.01982448,0.0799617,0.013267376,-0.016460933,0.09116009,-0.013026343,-0.071138725,0.0708402,0.15296601,0.05012372,0.016789284,0.037780274,0.19691037,-0.04868278,-0.021230023,0.074825026,-0.04443577,0.0075130905,-0.01913863,0.08122828,-0.034338105,0.0037058103,-0.06349274,-0.014003865,0.026461381,0.14701536,-0.07067456,-0.083051406,0.013598698,0.016613225,-0.074334554,0.0004863887,0.016280508,0.0114422375,0.012335079,0.021369308,-0.07071004,0.026024844,0.008406144,0.024365155,-0.03223585,-0.039005566,0.009628988,-0.049282636,-0.018098162,-0.05336612,7.052587e-05,0.012801798,0.009798776,0.0052935835,0.047370106,-0.0768052,-0.060193934,0.022497874,0.035865102,-2.3442467e-33,0.007875296,-0.07298818,0.024232034,-0.05462439,-0.009135149,0.0775074,0.0033082739,0.029672546,0.0012819545,0.039828103,0.022215769,0.031578973,-0.0032611138,-0.015221338,0.0011799581,-0.03205655,0.009736761,0.0712092,-0.0039475085,0.012141688,-0.036961023,0.12690899,0.07498428,-0.009265047,0.06914676,-0.001286415,0.057648063,0.017943567,-0.06933634,0.039933424,0.040623974,-0.06310881,-0.04580438,0.0438021,-0.058151003,0.04794519,-0.07867552,-0.024739949,-0.012595064,0.0039346344,-0.0024799616,-0.023132795,0.018561289,0.1238883,0.062967114,-0.00970536,-0.14911433,0.088533476,-0.04135366,-0.00086241524,-0.024660632,0.03069581,-0.018841501,0.065899365,0.06261228,-0.015725175,0.0017920503,-0.016091594,-0.06419135,-0.024586687,-0.019085376,-0.023527842,-0.024617294,0.02390527,0.069376394,-0.00805247,-0.028122306,0.006503008,-0.025255747,0.016945746,0.08659643,0.06615965,-0.032801695,-0.011384009,-0.010637421,-0.05501313,-0.028895006,-0.09819839,-0.09351211,0.008963178,-0.020632233,0.019473255,0.010281913,-0.030491052,-0.021442153,-0.08307385,-0.015926572,0.12845083,0.051109686,0.034200586,-0.056648266,0.0072055594,-0.044046886,0.05539752,0.10069358,-3.959872e-08,-0.024695722,0.0052613355,0.025639826,-0.043542437,0.036257736,0.011937118,-0.0084397355,0.008630301,0.053381104,0.008115339,-0.029853677,0.065293305,-0.0013817503,0.05366474,0.08293193,-0.05525271,0.08384882,0.056182012,-0.010341464,-0.013769558,0.017184027,-0.033387195,-0.05607821,0.037073545,0.0542945,-0.09704043,-0.032146044,-0.0156942,-0.011523446,0.06296273,0.07382811,-0.022091264,0.06474224,-0.008096304,-0.060086004,0.047653116,-0.002746822,-0.007364235,-0.009365823,0.03002391,-0.0129111,-0.05997384,-0.05003802,-0.016490133,-0.0072479895,0.058633298,0.03229723,-0.031937167,0.022652727,0.055679146,0.016886465,-0.088792935,-0.012249162,-0.037493937,-0.06246383,-0.096152805,0.035772245,0.0007354692,0.036284443,-0.031107547,-0.01767551,0.041938283,0.22715826,0.0042333733 +4.2.3.44,"The enzyme only gave isopimara-7,15-diene.",384,0.99999994,-0.05247799,0.05716524,-0.070706874,0.024231005,0.021483582,0.013278145,-0.11351825,0.06869855,0.03177673,-0.058224518,0.06901451,-0.05928899,-0.12834679,0.01654724,-0.06078886,0.0295169,-0.047954116,-0.030517124,-0.016212909,-0.10307856,0.01773267,-0.015819969,-0.010279962,0.0075531756,0.055964693,0.0121389795,0.015720975,0.012306309,0.009179227,-0.070653126,-0.01234525,-0.08225384,-0.0016565006,-0.025154386,0.037843704,0.004451636,-0.01650823,-0.025629476,0.07106686,0.053305667,0.033803057,-0.025373535,-0.094498165,0.0016358302,-0.04242535,-0.13498619,-0.042818375,0.02635072,0.053292096,0.06422872,-0.08334202,-0.06555706,-0.04746391,-0.012658295,-0.002055416,-0.13788295,-0.021248898,0.031845395,-0.077206805,0.005940307,0.017588858,-0.008011618,-0.03190954,-0.0023625214,-0.068884656,-0.06316406,0.027915444,-0.04649428,0.021164393,0.01387981,0.02362029,-0.06500112,0.044081006,0.07496903,-0.017666215,-0.025432827,-0.064243406,-0.05560568,0.011123693,0.021782158,-0.05913312,-0.035978194,0.00012417529,0.05552508,0.031205086,0.026363539,-0.043432765,0.09337893,0.011444311,0.017298646,0.052573208,0.018666279,-0.025026074,-0.014872541,0.023722349,0.033830155,-0.027791517,0.03950618,-0.09087754,-0.003588736,-0.0314313,0.018134104,-0.053210977,-0.030926926,-0.038805593,0.06508958,0.030977385,-0.05827051,0.012777019,-0.021556666,-0.039630126,0.0038962723,0.09870126,0.011646307,-0.03775142,0.07789953,-0.0003143821,-0.031301502,-0.04039157,0.06297444,-0.03870582,-0.038615413,0.1220958,0.09848418,-0.06636212,0.05811526,0.008563106,-2.6233777e-33,0.07431587,-0.013137603,0.057129223,-0.015288305,-0.06106574,0.021238929,-0.014443439,0.044542458,-0.011781813,-0.03812321,-0.11084448,-0.137969,0.03709836,-0.037802402,0.0348713,0.06874136,0.0757598,-0.045771673,0.045164224,-0.019561732,-0.0017432915,0.043637708,-0.07582042,0.02924654,-0.011717745,0.06926365,-0.008998802,0.07861147,0.01593303,0.00337003,-0.0885715,-0.03323526,-0.008065849,0.0144830365,0.024219522,0.050598137,-0.007761181,-0.009508418,-0.031192107,0.03846217,0.06985908,-0.0019994387,0.02290168,-0.05462026,0.087677464,-0.007378423,-0.11786239,0.07371872,0.07202149,0.0063319565,0.02991794,0.057217274,0.054568112,-0.010630883,-0.024670174,0.080160625,-0.006551527,0.06724855,0.031878043,0.040707838,0.026872626,0.01380736,0.067699715,0.04748156,-0.011255281,0.08178123,-0.09243207,-0.050986648,-0.048368044,0.06721618,-0.06944114,-0.0071337475,0.038292073,-0.02246505,0.039220802,-0.051241267,0.02622419,-0.03238536,0.032475736,0.0036182709,-0.024698738,-0.052839078,0.015089785,-0.026029918,-0.070529245,0.00046570948,0.01470427,0.037237693,0.033832014,0.009781279,0.04555671,-0.050969776,-0.12652123,0.013807255,0.008726822,-2.6932366e-34,-0.014408982,-0.07153355,0.031094082,-0.12083045,-0.040846635,0.1294803,-0.006786031,0.0065859854,0.030734057,0.040784556,0.18105504,-0.048104767,-0.010177514,-0.013970034,0.0028358768,0.08713716,-0.058627926,0.0530701,0.0033069323,0.032981433,-0.04966843,0.0851889,-0.05455974,0.08027471,0.03162071,0.028002048,0.025133714,0.038532734,0.025758423,0.021870073,0.07387364,-0.0015364356,-0.058284793,-0.017515093,0.0087781325,0.015853299,0.0005535114,-0.008816359,0.0180516,0.005086368,-0.058231257,-0.045609225,0.004696806,0.085295126,0.03916372,0.025441553,0.013424587,-0.076715745,-0.04069579,-0.10566783,0.05132257,0.052378926,-0.058615003,-0.005063817,0.05774897,0.04782215,-0.032672014,0.031200372,0.057187866,-0.052059025,-0.0039516566,-0.06442758,-0.0358681,-0.038152274,0.033338238,0.03812572,0.0007110944,0.04728192,-0.012122918,-0.020779256,0.098764665,0.049589835,-0.01848991,0.067944095,-0.022956572,-0.0086053405,-0.05869647,-0.047070816,-0.052242648,-0.084154904,-0.05968039,-0.06663054,-0.03527493,-0.10079136,0.017258378,-0.01608454,0.06456865,-0.030024849,0.019431528,0.10755644,-0.0042866617,-0.0021187342,-0.034126855,0.025678769,0.021654645,-1.9256952e-08,0.10645992,-0.04397553,0.060950585,0.016559882,-0.043849632,0.0065327426,-0.006716714,-0.012370508,-0.0015510469,0.08178326,-0.029645259,0.08231223,-0.001722587,0.05633524,0.0016411887,-0.040841565,-0.007727555,0.02625379,0.028959118,-0.026469544,-0.08211715,0.034661837,-0.029356482,-0.0991428,0.008890554,-0.08013753,0.031191207,0.0756879,0.05123732,-0.08816561,0.03259546,-0.041627195,0.045226797,-0.015401129,-0.09580966,0.09074368,0.04151158,0.025570568,-0.036971234,0.0122132655,-0.019868704,-0.08603919,-0.06089057,0.0086642895,0.030879252,0.021564284,0.043336667,-0.03849047,0.0120153455,0.008012286,0.020358408,0.051058877,0.01839513,-0.028064527,0.011916167,0.019847801,-0.04185483,0.0030132856,-0.020974955,-0.048454817,0.06882652,-0.050543603,0.10424161,0.025570216 +1.5.3.14,"As the products of the reaction cannot be converted directly to other polyamines, this class of polyamine oxidases is considered to be involved in the terminal catabolism of polyamines [1]. This enzyme less efficiently catalyses the oxidation of N1-acetylspermine and spermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.15 [N8-acetylspermidine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase). ",384,0.99999994,-0.01881423,-0.07114269,-0.09795537,-0.026357159,0.1330134,0.029222464,-0.008717692,0.007843233,0.0361848,0.006063159,-0.02382284,0.08067622,-0.08189711,0.014448243,-0.055982485,0.050090738,-0.02599822,-0.06482435,-0.012804272,0.019201174,0.071689546,-0.03791226,0.014196807,-0.030910527,0.012841135,-0.026230456,0.03765907,-0.03298969,-0.05129171,-0.02729728,0.07004858,0.02822523,0.04574909,-0.041562386,-0.049665324,0.03699107,-0.0018409548,-0.036705256,0.014472676,0.046939682,0.06309578,0.014812136,0.02868662,-0.05642697,0.05965666,0.00013598657,0.0022740236,-0.013246524,0.016907811,0.045269955,0.027015988,-0.066802144,-0.009410186,0.033615243,0.027153222,0.022918044,-0.025342887,-0.0573984,-0.043252125,0.063229874,-0.026271963,0.047872327,0.012011386,-0.029650448,0.029571706,-0.05628864,0.025945524,-0.05897548,0.051409632,-0.01712431,-0.053581793,-0.011251994,-0.037614357,0.032716043,-0.019941542,-0.006209444,-0.03788999,-0.015472879,0.0145219825,-0.033795092,-0.057913717,-0.06395935,0.023753965,0.06278149,0.060221285,0.030703498,-0.022786595,-0.0154019315,0.02493495,0.05650982,-0.041681953,-0.006935981,0.07644285,0.012112911,-0.051167767,0.0032539382,0.066232525,0.032834582,-0.055865716,-0.03890445,-0.02645823,0.0547089,-0.0024764363,-0.09264536,-0.088573694,-0.026962204,-0.008870802,0.0725662,-0.026018875,-0.018029293,-0.031844992,-0.049681243,0.029514458,-0.013801664,-0.002293114,0.07558516,-0.04961055,-0.056548037,-0.049900327,0.01162526,-0.020030838,0.059449676,0.08518893,0.12357502,-0.0017923597,-0.019411977,-0.06302294,4.5032645e-33,0.06390089,0.024166903,-0.03416892,-0.009086827,0.019815525,0.061953958,0.016612925,0.010611446,0.0938476,-0.054877985,-0.062901065,-0.010086685,0.07835699,-0.04316814,0.031048506,-0.013466263,-0.04245587,-0.06924371,0.10053052,-0.047801677,0.015638333,0.047706608,-0.023685388,0.0486491,-0.007365394,-0.039535154,-0.027847009,0.037594404,0.022279887,0.0027557611,-0.011692747,-0.05246141,-0.06402122,0.010971954,-0.081353806,0.068682425,-0.05235657,-0.07944973,-0.07727287,0.095760666,-0.009023622,0.0019498068,0.009882785,-0.0023194295,-0.022018127,-0.058526322,-0.07588333,0.1222321,0.041761424,0.07835698,0.0004638488,-0.007960551,0.12885113,0.027555276,-0.09636827,0.01395018,-0.07939927,-0.06506758,-0.0111094685,0.040385496,0.05846975,0.017988246,-0.0076564914,0.05753643,-0.06888038,0.026930775,0.009802842,-0.056688763,0.007893081,0.051850166,-0.021580406,0.0026394965,0.10116765,-0.029312871,0.13269818,-0.036688346,-0.092195824,0.03704523,0.011073507,0.029077554,-0.0067801033,0.027491856,-0.059677396,0.010535283,-0.04762243,0.060618915,0.06484717,-0.00026695128,0.030944776,0.07123813,0.0376837,-0.15439549,0.033887263,0.006111874,0.04001812,-3.7388828e-33,0.030942129,-0.08729017,0.0072531747,-0.005151971,0.023194363,0.035301555,0.09882581,-0.037430346,-0.04570081,-0.09169075,0.022034723,-0.061982896,0.03688355,0.013003881,0.0015633029,0.0077133253,-0.07975347,0.06644493,0.044930354,0.003936121,-0.0032308858,0.026549542,0.021701053,0.05695482,0.051586594,-0.028513975,-0.002143829,-0.05160087,0.03592674,0.047732588,-0.049678747,0.04169574,-0.045382746,0.04090524,-0.059945103,0.057031453,-0.08023241,0.00054423395,0.023723533,0.024613949,-0.039735977,0.028018063,-0.01794427,0.048511352,0.0031655077,0.07669957,-0.10536433,0.060286537,0.052873287,-0.020538202,-0.013097709,0.0602657,-0.05211482,0.002154156,0.08451339,0.049135603,0.019148454,0.052670468,-0.005174823,-0.023435991,-0.039357506,-0.028978718,0.0272521,0.036591206,0.07777284,0.039897136,-0.008850883,0.17233121,0.017908724,0.015799526,0.11259165,-0.028568868,0.10622435,0.047769204,0.04588362,-0.11869924,-0.019319547,0.05012324,-0.007974445,-0.03030646,0.022740014,-0.041428696,0.0058426377,0.011780751,-0.07926727,-0.04089403,0.053939987,0.0759939,0.0075942837,0.017169677,0.0013745539,-0.00060111645,-0.016162423,-0.010175758,0.10281699,-4.6838394e-08,0.043610442,-0.069425285,0.030637713,-0.0012985662,0.03324506,0.06933453,-0.029794961,-0.004543035,0.0067071947,-0.08781087,-0.017129194,0.115772724,0.027752241,0.033020224,-0.009186008,-0.04837113,-0.0013330899,0.047786422,0.007059523,-0.015860483,-0.112730384,0.011366675,-0.13417578,0.0065863463,-0.032760575,0.00493126,-0.029930023,-0.025564138,0.002997057,-0.021611191,-0.0064422563,0.030090315,-0.015316346,-0.09567766,-0.06743163,0.05323934,0.050496697,-0.027692528,0.0037694068,0.032876663,-0.08667883,-0.09501558,-0.05020495,0.009267423,0.08971357,-0.074042544,0.03989073,-0.048009545,-0.06301472,-0.029736962,0.015571419,-0.029203424,0.026203042,-0.071291916,-0.02840963,-0.003928127,-0.06712746,-0.10196471,-0.030018281,-0.034516342,0.0005950575,0.051943485,0.14958352,-0.0004644961 +1.5.3.13,"The enzyme also catalyses the reaction: N1,N12-diacetylspermine + O2 + H2O = N1-acetylspermidine + 3-acetamamidopropanal + H2O2 [1]. No or very weak activity with spermine, or spermidine in absence of aldehydes. In presence of aldehydes the enzyme catalyses the reactions: 1. spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2, and with weak efficiency 2. spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [2]. A flavoprotein (FAD). This enzyme, encoded by the PAOX gene, is found in mammalian peroxisomes and oxidizes N1-acetylated polyamines at the exo (three-carbon) side of the secondary amine, forming 3-acetamamidopropanal. Since the products of the reactions are deacetylated polyamines, this process is known as polyamine back-conversion. Differs in specificity from EC 1.5.3.14 [polyamine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.15 [N8-acetylspermidine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase). 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No activity with diaminopropane, putrescine, cadaverine, diaminohexane, norspermidine, spermine and spermidine. Absence of monoamine oxidase (EC 1.4.3.4) activity. Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase). ",384,1.0,0.054516558,-0.09799732,-0.04485099,-0.06567974,0.085512206,0.035528783,-0.0227494,-0.011117125,0.016988697,0.01085473,-0.00044935985,0.0053103287,-0.06346953,0.11149978,0.041004337,0.042703375,0.057964485,-0.11943259,0.0003274553,0.013092826,0.05964898,0.0003551468,0.004723706,-0.026643746,-0.00063515606,0.0016113586,0.015101417,0.051196225,0.009009557,-0.04535369,0.017743578,-0.027468272,0.054324053,-0.031660307,0.023624793,-0.0010524273,-0.027265351,-0.020148901,0.010832198,0.042834528,0.04641248,0.027449235,-0.04763443,-0.0022283194,-0.003786023,-0.020453509,0.027192308,-0.0458055,0.016839353,0.019571,0.057369024,-0.05599819,0.08540878,0.071197554,0.054272857,-0.01506603,-0.09643603,-0.016353996,-0.02755993,0.081753284,-0.020493617,0.06471125,0.029180702,-0.07341583,-0.004049299,0.03278739,0.03993207,-0.039299283,0.060847003,-0.021100493,-0.045941196,-0.051933404,0.0321021,0.06570779,-0.022759493,-0.037631664,-0.018462894,-0.034249566,-0.0075928164,-0.09961981,-0.13697532,-0.041826464,-0.067192905,0.058335125,0.04271034,0.044441752,-0.018186783,0.016573401,0.009644767,0.0070884335,-0.0322019,-0.06066659,0.06954116,0.0027309794,-0.008052028,-0.04274715,-0.0033667742,0.06756393,-0.06323094,-0.019706551,-0.01786019,0.10462522,-0.007584156,-0.053245403,-0.08215667,0.06167327,0.044669956,0.010681838,-0.006703464,0.012595557,-0.036590062,-0.05148999,0.05075785,0.06669494,-0.037288662,-0.0009473419,-0.02268563,-0.04875263,-0.05249129,0.025363404,0.051433716,-0.045377713,0.086210325,0.04737692,-0.023144668,0.051148605,0.0011271184,4.830197e-33,0.046555027,0.014366862,0.03533639,0.044901635,0.039647516,0.10344135,0.01955174,0.050023098,0.13846049,-0.068302885,-0.029781733,0.023511676,0.059443213,0.02137776,-0.02728831,-0.015196719,0.018697608,-0.0849908,0.080756456,0.024742944,0.014633991,0.028990172,-0.034720883,0.019822478,-0.030363798,-0.039671816,-0.0039351815,0.015182545,0.0661709,-0.02638594,-0.03107086,-0.08086772,-0.04251741,-0.019608209,-0.056251924,0.07626664,-0.021284023,-0.0075564166,-0.05149896,0.028725695,-0.034890275,0.025436766,-0.041094225,-0.047778934,-0.036490805,-0.11935483,-0.06833413,0.10096772,0.025764441,0.030031808,-0.02875609,-0.038751263,0.045634773,-0.0637863,-0.04598491,0.0011382954,-0.06827613,-0.021089876,-0.00841235,0.005499099,0.08080406,-0.028158013,-0.02274819,-0.04513448,0.018342774,0.052352764,-0.046450324,-0.03129771,-0.029683216,-0.0043410365,-0.03646319,0.04371026,0.04374119,0.00030441317,0.07438669,-0.042982236,-0.11958024,0.06896615,0.054130506,0.007032308,0.016542442,-0.022680882,-0.0007274138,0.035709135,-0.083198495,0.055217262,0.06325902,0.0070432583,-0.000490667,0.04124072,0.035433285,-0.10053164,-0.032504816,-0.004190037,0.027370878,-4.1553916e-33,-0.0076349457,-0.053033136,0.0015353194,-0.017976522,0.029494694,0.07338992,0.046322368,-0.018897304,-0.039080624,-0.08864677,0.0924046,-0.034890942,0.01971978,-0.021645885,-0.015574671,0.018010749,-0.07050508,0.1049328,0.026292091,0.024251483,-0.032813285,0.025859376,-0.05587001,0.05536731,0.087611146,0.016812311,-0.009639657,-0.05058629,0.031519488,0.06384289,0.023170749,0.09732166,-0.04320031,-0.030196315,0.011486129,0.0378485,-0.09059031,-0.010222943,-0.023773326,-0.04920857,-0.04433058,0.0770358,0.015038491,0.05927378,-0.014250938,0.119159676,-0.12564048,0.06166644,0.023135647,0.063686386,-0.040290914,0.006123344,-0.08442691,-0.023743253,0.076523036,0.05352509,-0.0076668723,0.021297421,0.031191828,-0.04684081,-0.05417065,0.050785262,-0.062330738,0.06646628,0.0356557,-0.024651788,-0.07464727,0.16007017,0.0851583,0.0014681569,0.062798776,-0.05131142,0.109114796,-0.074389756,-0.026198117,-0.06752289,-0.0498515,-0.029054128,-0.00019876739,-0.056591738,-0.0008454018,-0.039966103,-0.05626142,-0.02185075,-0.0596845,0.08605834,0.023494398,0.069282405,-0.030548403,0.03756406,0.008522934,-0.03148301,-0.09992275,0.052687608,0.03656259,-4.7067452e-08,0.107152395,-0.03847609,0.056417186,-0.038875494,-0.023963645,0.020518364,0.0323377,0.030336672,0.030083766,-0.04418931,0.057309974,0.015479189,0.004808954,-0.008186964,-0.007517767,-0.022682486,0.050825603,0.09519965,-0.0069488287,0.034052964,-0.0476854,-0.039079163,-0.08248251,0.01299525,-0.0024139527,-0.018272512,0.023222493,0.010942783,0.016386395,-0.03988212,0.027942693,0.034059413,0.013966338,-0.13152947,-0.004558389,0.08043051,0.023272634,0.060239796,-0.02829645,0.013131218,-0.019478746,-0.113363765,-0.05020548,0.009770621,0.13915262,-0.052963614,0.048911482,-0.019895537,-0.04725285,-0.10026623,-0.02191609,-0.021684911,0.046397153,-0.07026476,-0.06851189,0.046321746,-0.06663224,-0.0314968,0.0053058947,-0.066031754,0.01609703,-0.021197617,0.088080004,0.04023002 +1.5.3.16,"The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency [3]. The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyses the oxidation of spermine at the exo (three-carbon) side of the tertiary amine. No activity with spermidine. Weak activity with N1-acetylspermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming) and EC 1.5.3.17 (non-specific polyamine oxidase). ",384,1.0,-0.07062725,-0.03156714,-0.07211489,-0.01883318,0.14609882,0.033435237,-0.06128505,0.015619369,0.04787101,0.010441526,0.046411827,0.026426984,-0.10578148,0.035325136,0.001689963,0.055325348,-0.016943302,-0.038045023,-0.0027573647,-0.0007587204,0.081052005,0.022925833,0.010614601,-0.035726085,0.025365744,-0.018692272,-0.041453112,0.01029131,-0.037085295,-0.051177286,0.044113263,0.03141403,0.08078098,-0.016777063,-0.02051824,-0.0027045247,-0.014841908,-0.048882615,0.016466912,0.028613634,0.06223279,0.0113473805,-0.020580346,0.008651255,-0.0017246997,-0.020258496,0.041979577,0.014945717,0.05816513,0.048851542,-0.03984361,-0.053350586,0.0001835352,-0.013081506,0.043876942,-0.02287276,-0.04560022,-0.044698875,0.012240043,0.07980494,-0.013230727,0.02250645,0.022914039,-0.040108968,0.06311896,-0.046954013,0.0007730152,-0.046844937,0.06788629,-0.0548252,-0.010215739,-0.04810118,-0.014642321,0.05235342,-0.015662493,0.047989555,-0.036060594,0.023687111,0.006125074,-0.008169461,-0.056527708,-0.07256494,-0.04661563,0.037828103,0.0578105,-0.005368657,-0.047613837,0.0028960502,0.032283597,0.059273995,-0.052927464,0.0073630796,0.048069276,0.0073913513,-0.0099567985,0.033870224,0.041151013,0.0045050965,-0.101167314,-0.0064343275,0.008877329,0.1072113,-0.027415983,-0.08271545,-0.04376088,0.016716413,-0.014570317,0.039736155,-0.040371172,0.007335742,-0.033248242,-0.040695492,0.01698888,0.010299269,-0.007066291,0.030716732,-0.06886115,-0.028622884,-0.036080293,0.0027947554,-0.025690151,0.008748457,0.030352341,0.09171862,0.0057812654,0.03177885,-0.0551841,5.3167444e-33,0.07500146,0.014859895,-0.028014135,0.026760682,0.027836628,0.053391036,0.024475122,0.024861433,0.04239843,-0.096484,-0.06530351,0.0052391244,0.047413025,-0.033769447,0.009291145,-0.051890958,-0.061552692,-0.081108496,0.10565652,0.0035117157,0.032261167,-0.02426786,-0.04713725,0.005224989,-0.006863412,-0.033230912,-0.04256205,-0.009549312,0.04948624,-0.0060871663,0.020958953,-0.0647448,-0.08075889,-0.029616173,-0.019607183,0.036747627,-0.0865444,-0.057199642,-0.09315908,0.08816123,-0.07556595,0.027278628,0.0041035474,-0.018959364,-0.038085748,-0.058449242,-0.09577948,0.14810626,0.042114243,0.054402847,0.00060753536,-0.040812142,0.1206109,0.0041797548,-0.05249498,0.010234327,-0.033808544,-0.017574126,-0.048332687,-0.0073559214,0.03503927,-0.01165752,-0.011284203,0.03191515,-0.009906059,0.052522518,-0.08163453,-0.03072961,0.039464153,0.08518041,0.0069274846,0.032938376,0.07040544,-0.03460498,0.044587832,-0.053661108,-0.10352541,0.07183423,-0.001516191,0.033177316,0.040391248,0.0137876505,-0.057480615,0.024751069,-0.068305045,0.052867975,0.0382822,0.03649502,0.009794207,0.0061180866,0.10005458,-0.13131216,0.03228192,-0.042044375,0.04514177,-3.4934414e-33,0.027365975,-0.07950659,0.047980517,-0.017792387,0.036874723,0.024446435,0.08374778,-0.0034400907,-0.07394198,-0.07126298,0.01633719,-0.04820603,0.068355404,-0.045095515,0.038078226,-0.014665399,-0.033695832,0.08193282,0.061468303,0.018195651,-0.056559328,0.027415596,0.01560711,0.084053494,0.07437337,-0.021603322,-0.009487158,-0.030423483,0.00759608,0.025074154,-0.015721008,0.13179986,-0.056448054,0.011499838,0.0023393398,0.065950684,-0.092893004,0.011390336,0.043799374,0.009400771,-0.03219076,0.08597004,-0.024536619,0.07636123,0.005545957,0.1302627,-0.0923684,0.05061248,0.0027739208,0.019705804,-0.018861223,0.06538395,-0.06516434,0.014225951,0.12501802,0.04757444,0.019897237,0.024658509,0.014337841,-0.0088406755,-0.03852081,-0.028894527,-0.05920976,0.048484605,0.04542736,0.025311144,-0.035482075,0.17363326,0.00976791,0.03181822,0.09696794,-0.023019733,0.109006755,-0.022288905,0.02774175,-0.07669524,-0.018948477,0.066123195,-0.052820783,-0.0014837986,0.036897402,-0.02096624,-0.030792883,0.019580837,-0.06907042,-0.022079224,0.04814744,0.09836716,-0.009566865,0.07050341,-0.022465514,-0.018369429,-0.032663446,0.027687533,0.110552974,-5.1223118e-08,0.001445618,-0.04227483,0.07300011,-0.008904738,0.017777575,0.0587095,0.003842054,0.014396682,0.021476094,-0.05791049,0.001537705,0.06583796,0.026025157,-0.022673361,0.048889104,-0.05339377,0.030494811,0.091060914,-0.0018503438,0.039647855,-0.050116006,-0.004310817,-0.15686864,0.05821166,-0.042496666,0.010809874,0.0143468715,-0.039243605,0.07310864,-0.060421947,-0.0010606978,-0.0015911373,0.021187423,-0.099478826,-0.15172395,0.014798765,0.051645607,-0.030758869,-6.804686e-05,-0.00010664706,-0.046743885,-0.06390533,-0.085461676,-0.01703965,0.07177864,-0.023367232,0.07778587,-0.005420574,-0.08336812,-0.019838598,-0.029464426,-0.013325849,0.020087559,-0.05941592,-0.062282324,-0.04144612,-0.053690627,-0.016269341,-0.022759952,-0.04358761,0.010307763,0.0427533,0.13445795,0.0130324 +1.5.3.17,"A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [3]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [2]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [1]. +The specific polyamine oxidases are classified as EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 1.5.3.16 (spermine oxidase).",384,1.0,-0.008761979,-0.10376745,-0.10179883,-0.022553302,0.149051,0.05419341,-0.0497602,0.018287424,0.05233837,0.0016433877,0.05498915,0.049116965,-0.110211626,0.028991204,-0.05665636,0.04236834,0.019556908,-0.05355955,-0.0397133,-0.0026964636,0.1293768,0.021526298,0.009427806,-0.017557455,0.014716575,-0.043499585,-0.0092380745,-0.025119873,-0.05772499,-0.07422579,0.014712633,0.064366885,0.09643114,-0.0117368745,-0.01798735,0.041906852,0.010875132,-0.07036116,0.061294198,0.043584667,0.025352478,-0.0021345906,-0.0062797316,-0.015450755,-0.014483124,0.00074001297,0.007554191,-0.014668873,0.049462292,0.029160758,0.0009867508,-0.05032564,0.016158905,0.018709274,-7.75379e-05,-0.0036564765,-0.02379562,-0.04141159,0.012186931,0.057525028,-0.05334438,0.017160665,0.038520917,-0.044204973,-0.0010076108,0.0027258128,-0.019309292,-0.022422872,0.04022953,-0.035982147,-0.010928577,0.004422204,0.0022801096,0.069386534,-0.009920106,0.015345012,-0.03973146,-0.020766225,-0.009072052,-0.061882544,-0.058703404,-0.06364299,0.005994181,0.031233666,0.070284136,0.005190945,-0.03695772,0.022640143,0.028108647,0.05278465,-0.007895128,0.012315659,0.06502609,-0.0074933986,-0.016758302,0.03210395,0.07000725,0.0032052668,-0.06644061,-0.05157741,-0.004856845,0.04298865,-0.014027327,-0.06883912,-0.024893025,0.02867305,-0.01004602,0.027205868,-0.010364451,0.0077413735,-0.047124807,-0.046513077,0.008458081,-0.0012417226,-0.003884291,0.010178482,-0.028410207,-0.029678743,-0.069235995,-0.008737253,0.009242473,0.042044643,0.07462147,0.08969027,0.00810379,0.028100478,-0.105028965,6.8598765e-33,0.06663501,0.042733252,-0.045805722,-0.012460668,0.017553098,0.039068807,0.027111204,0.054071058,0.057932004,-0.06891697,-0.08117898,0.033271927,0.06650299,-0.021500744,0.02509655,0.011966595,-0.027812723,-0.08753281,0.09168804,-0.031485084,0.023535732,-0.006297828,-0.06508913,0.015291499,-0.019321537,-0.09582667,-0.00056426134,0.0036056873,0.017167592,-0.026426489,0.006977423,-0.09389376,-0.059246674,0.01860005,0.025495572,0.06324844,-0.073466584,-0.051335774,-0.1227712,0.054154705,-0.053576358,0.0140674645,-0.00445205,-0.031649377,-0.03016349,-0.067812115,-0.077285215,0.1030587,0.056511518,0.07918193,-0.007251782,0.011125853,0.13851252,0.010907294,-0.048667,0.0169043,-0.030484967,0.019868925,-0.027580494,0.030181115,0.021651005,-0.0233109,-0.037850678,0.030975416,-0.05087783,0.06588076,-0.066183515,-0.03466799,0.012942547,0.07917035,-0.016721174,-0.005407138,0.07357338,-0.011718672,0.047852397,-0.0010975157,-0.13538109,0.05193176,-0.008525197,0.047149967,-0.02051905,-0.020060908,-0.04178306,0.024979964,-0.10341611,0.06701364,0.064150386,0.038625717,0.01781248,0.0077904654,0.09435812,-0.12604986,0.044413798,-0.033858042,0.0686603,-4.6960228e-33,0.027149359,-0.048330992,0.044035424,-0.019459393,0.03199757,0.052485403,0.10054807,-0.025929058,-0.09071288,-0.11230564,0.03909376,-0.011006007,0.039088372,-0.027877187,0.02984054,0.024389904,-0.04476248,0.115341276,0.06604656,0.024436995,-0.04888264,0.050856665,0.035128582,0.05269086,0.08338062,-0.024616301,0.006990648,-0.02703584,-0.0110977115,0.039586104,0.0021485728,0.090122916,-0.029318234,0.02445883,-0.021859465,0.028000468,-0.10982621,-0.038542073,0.021719243,0.0102937315,-0.048702795,0.048857287,-0.01637419,0.055900116,0.006800968,0.096095234,-0.11018161,0.062618,0.043328885,0.024615528,-0.042727675,0.030162828,-0.062027212,0.014121769,0.118923016,0.0055378582,0.0002449613,0.04638298,0.0036987744,-0.031551324,-0.014330446,-0.02281343,-0.017215852,0.063799314,0.04395066,0.016068464,-0.022962177,0.10801095,0.0050917896,0.054940283,0.06857893,-0.022634417,0.09258493,0.038765185,-0.0001060648,-0.124121934,0.0043858807,0.041022506,-0.061173964,-0.0031176687,0.029505784,-0.041031733,-0.01874413,0.027148962,-0.09531302,0.01704921,0.043785073,0.05990062,-0.0044090026,0.074326135,-0.015535735,-0.016847027,-0.04581557,0.019756133,0.11108542,-5.0554387e-08,0.023868283,-0.03308764,0.06633615,-0.06166296,0.04871358,0.02590263,-0.0028553868,0.010041284,0.004622905,-0.034704637,-0.012032836,0.069711804,0.025976084,0.015007788,0.040555455,-0.1062897,0.033329397,0.07672721,0.013001822,0.032031965,-0.049591854,-0.006233842,-0.14346156,0.05348443,-0.008630786,-0.0045817997,-0.0023204116,-0.048705615,0.06807032,-0.03284656,0.024662765,0.011852246,0.023652557,-0.14493309,-0.07460636,0.07085865,0.02126891,-0.021642182,0.0049239397,0.055224117,-0.04824619,-0.06952369,-0.06883699,0.013879099,0.100616656,-0.0767366,0.079871096,-0.0318912,-0.029741732,-0.043962866,0.01388757,-0.030802792,0.027704379,-0.065637976,-0.05756309,-0.017416423,-0.048081595,-0.053769145,-0.020035328,-0.04461411,0.024868255,-0.008939766,0.14858836,-0.018549928 +1.1.1.298,"Catalyses the reduction of malonate semialdehyde to 3-hydroxypropanoate, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively [1,2]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 1.2.1.75 [3]. Different from EC 1.1.1.59 [3-hydroxypropionate dehydrogenase (NAD+)] by cofactor preference.",384,1.0,-0.021383576,0.0025435004,-0.040503096,-0.05989787,0.064448714,0.057640836,-0.060795773,-0.027081449,0.011102263,-0.026565347,0.0022135847,-0.09934045,-0.04134649,-0.041673277,-0.027297307,-0.013654118,-0.071814045,-0.048401717,0.04640321,-0.055207316,0.06385992,0.021148808,-0.06814776,-0.015085533,0.03259759,0.0636029,0.0040054037,-0.056534793,-0.04578894,-0.05333658,0.012299745,0.0057780268,0.0078077875,-0.09359978,0.038063228,0.07822134,-0.035908468,-0.07459332,0.06419355,0.013086207,-0.0019126364,0.03187918,-0.059952907,-0.017073523,-0.11212809,-0.0045260666,0.029305708,-0.026632223,0.039144367,-0.0760934,-0.07026098,-0.014505414,-0.0679701,0.009412111,0.027522426,-0.02331207,0.027248919,0.045738626,0.063731864,-0.046235982,0.044331107,-0.03730899,0.021395097,0.020564958,0.025836816,-0.031371593,0.020969655,-0.0719006,0.032099735,-0.032011457,-0.12346791,0.01048191,0.021409383,0.019102732,0.050987035,0.07171148,-0.029853623,-0.08143861,0.03775172,-0.042924624,0.0074243424,0.031289656,0.02601221,0.0729039,0.046157874,-0.1052069,0.050374113,-0.060383365,0.04967077,0.023215493,0.03762332,0.0058064666,0.031675104,0.0024789043,-0.06575979,0.111577,0.015346075,0.04861554,0.031374797,-0.0785809,-0.0029933627,0.03195763,0.0018899434,-0.09291306,-0.041688107,0.017144814,-0.013932782,0.19742392,0.05857521,-0.0014978189,-0.043425433,-0.010609039,0.00041821648,-0.028705698,-0.044762116,0.16684946,0.05466248,-0.08942214,-0.078263246,-0.0487347,0.035873033,-0.027746195,0.0554395,-0.031384546,-0.0573213,0.08240939,-0.11764468,3.801816e-33,0.05895031,0.030671215,-0.042004474,-0.068533376,0.031065913,-0.06962278,-0.14115478,0.03167234,-0.017915348,-0.052962784,0.0003188849,0.0019164929,0.052986592,-0.021070976,-0.05189847,-0.081791855,-0.04488082,-0.014240134,0.008055628,0.06334444,0.0048736385,0.03011234,-0.0030027993,0.016988548,-0.0012465556,-0.012494277,0.060102414,0.03553451,0.015019894,-0.0005563383,0.032567147,-0.119233094,-0.045871105,-0.025463978,0.11269589,-0.030807894,-0.02947016,-0.038203906,-0.044390578,0.006625484,-0.028697722,0.06948769,-0.0068528214,-0.083268926,0.049059667,-0.066495195,-0.015445413,0.08379912,0.027119529,0.09590806,-0.001302772,-0.0038930892,0.07494571,0.020589197,-0.054555133,0.049781553,-0.010810488,-0.009612702,0.041536544,-0.009329476,0.018409556,0.08806699,0.019577488,0.010574652,-0.012250482,0.036689006,-0.008283431,-0.013660814,0.03746284,0.027291035,-0.09200645,-0.020380126,0.034303457,0.030934397,0.046499763,-0.06837635,-0.03385661,-0.029794216,0.025513701,0.027525825,-0.028884348,0.067754656,0.07834891,0.0006146231,-0.02885014,0.007296866,-0.06691369,0.040728614,-0.030485887,0.065877795,0.072661996,-0.06315046,0.017181836,-0.023068763,-0.0447089,-4.7167475e-33,0.10936261,-0.08048281,0.030109355,-0.113393106,-0.017828269,0.087210834,0.0570507,-0.03552969,0.0012406376,-0.0139682945,0.0881108,0.0946554,-0.0002445418,-0.016446413,0.0639889,-0.02253898,0.012696631,0.027408872,-0.033947457,0.0077669765,0.11104423,0.057369664,0.0005413213,0.078677066,0.009757636,0.017941987,0.057460558,0.041530672,0.06561954,0.0324201,-0.02637042,0.036250763,-0.043652713,-0.018133128,-0.0067685987,0.026777098,-0.0925502,-0.011922307,-0.0089077875,0.061640505,0.0023088155,0.0049601845,-0.048458617,0.03762038,0.051342558,0.03571536,-0.08418784,0.054044288,0.017636683,0.030931229,0.0031494307,0.017688375,-0.06367588,-0.00996903,0.017127018,0.031079605,0.03968687,0.03489656,0.013768979,-0.00075860874,-0.08417954,-0.009879783,0.08840454,-0.02806814,0.024192683,0.06629002,-0.038462568,0.02279334,0.032418054,0.012833897,0.039904658,-0.01198438,-0.03316081,-0.024582002,-0.020158114,-0.009306198,-0.06258759,0.018887807,-0.023773618,0.007871506,0.04665368,0.031184824,0.037829164,-0.083457366,-0.019934505,-0.08736067,-0.04360534,0.026813168,-0.07934755,0.038935784,-0.023800703,-0.03352288,-0.0040407083,0.040653713,0.10634646,-4.6779565e-08,-0.032948833,0.018009117,0.10621894,0.042946726,-0.0037442537,0.019783009,-0.0007302834,-0.011623055,0.05690141,-0.034214895,0.038377143,0.00931662,0.07627419,-0.0024998232,-0.043005157,0.007482923,-0.045684025,0.005757595,-0.050792184,0.036961682,-0.07750036,-0.049385305,-0.15977737,0.056019016,0.061181586,-0.068259425,0.08034051,-0.011872131,0.0021437327,-0.062491257,0.01002056,0.059572063,0.0020534187,-0.035375502,-0.056316957,-0.029900437,-0.07773081,-0.022904884,-0.052841514,0.014880919,0.0060072793,0.018666,-0.08088591,0.012120742,0.02197495,0.061246734,0.016829612,0.070949756,-0.06269672,0.017943092,0.07336465,-0.039097194,-0.0004111645,-0.018939804,-0.058352035,0.033392344,0.011082537,-0.08868695,-0.028334025,-0.003215709,0.017956184,-0.014394644,0.12911841,-0.018959971 +1.1.1.299,"This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1]. +Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).",384,1.0,-0.054552685,0.035975065,-0.046995062,-0.028791513,0.061318457,0.060992934,-0.107421145,0.032237478,0.04396887,0.027023515,-0.031526774,-0.06918843,-0.08383857,-0.044473864,-0.0500993,0.025171172,-0.0069583273,-0.023207773,0.057099096,-0.010609474,0.08621118,0.05961488,-0.030916207,-0.0090583665,0.08977165,0.012960854,0.009999804,0.05429354,-0.04196164,-0.055029694,-0.009814838,-0.031080212,0.049835805,-0.020588525,-0.03643421,0.10401078,-0.04672869,-0.0710089,0.032612957,0.031324975,0.00951032,0.042329907,-0.014292985,-0.0667895,-0.020728793,-0.044999707,-0.002826185,0.02284174,0.03267192,-0.06354321,-0.06411384,-0.059206672,-0.019150354,0.042021696,0.060011584,0.029799929,0.0035584886,-0.02259896,-0.02659201,-0.05472168,0.026344933,-0.014619134,0.016373364,0.008289454,0.027530307,-0.049674887,0.04123187,-0.10340341,0.05523946,-0.08988008,-0.14645581,-0.008883334,0.008960742,-0.0018135321,-0.064496845,0.03819081,-0.07718004,-0.05725452,0.07895752,-0.03012812,0.011550204,0.016859604,-0.03590526,-0.039220322,0.030178225,0.031926036,0.037838012,-0.0064773415,0.07693232,-0.01901858,0.020867774,0.008306603,0.003180137,-0.016766757,-0.10899438,0.02206259,0.06953335,0.07792599,-0.017037788,-0.014892958,0.051639423,0.12022009,-0.051799856,-0.10076211,-0.07512747,0.00656497,0.04772992,0.104348846,-0.01293461,0.016824862,0.0067125494,-0.06072846,0.03889747,0.031519227,-0.03722828,0.120854504,0.006019555,-0.0726273,-0.07487855,-0.017198427,0.03502068,-0.062266815,0.09184388,0.025574991,-0.012945952,0.06081468,-0.10094244,3.520371e-33,0.0995306,0.028433193,-0.04911444,-0.035959568,0.059387427,0.009470555,-0.12572101,0.07429112,-0.028193276,-0.04840008,-0.058094352,0.011887867,0.034148972,-0.035203375,0.007945115,0.032942332,-0.016655166,-0.050935622,0.0145945335,0.037721448,-0.035838928,0.03514234,-0.0049999584,0.014805687,0.054453906,0.024476318,-0.016759692,0.02873064,0.0002224917,0.008423745,0.02972914,-0.084680334,-0.14066061,0.035689954,0.051809836,0.00071567565,-0.07130886,-0.056969255,-0.023444295,0.0053676497,-0.007157047,0.050071068,0.032596752,-0.039152585,0.04042389,-0.041790526,0.001555672,0.1305298,0.05207917,0.04230053,0.01963714,0.0011790458,0.10386669,-0.07940317,-0.06631959,0.047673117,-0.011532276,0.0047170892,0.054552577,0.10277385,-0.0041754018,0.019028103,0.0152048245,0.059507098,-0.044871286,0.0006443376,-0.07954199,-0.023486944,0.044463757,0.049535792,0.004175044,0.032151107,0.05303295,0.06351662,-0.0035557293,-0.05062837,0.040269468,-0.02780408,0.014366534,0.010298979,-0.0032270574,0.00040862104,0.00964497,-0.05244047,0.030911086,0.053416193,-0.009711597,0.022383748,0.027699905,0.044131685,0.00150367,-0.041873086,-0.054931805,-0.005092446,0.04385886,-3.50872e-33,0.06763683,-0.058485672,0.00066762435,-0.11179243,-0.040755596,0.096647896,0.007593096,-0.08030948,-0.0017161404,-0.08581204,0.11622467,0.0022739514,0.08861479,-0.08636014,0.06255696,-0.035616707,-0.020204125,0.014133765,-0.029139977,0.011344232,0.035893295,0.08474211,-0.04101475,-0.08628578,0.029904133,-0.024134096,-0.05214852,0.065125756,0.033309646,0.023471106,-0.013388814,0.037910715,-0.05302195,-0.05777452,-0.069794856,0.04033055,-0.044490054,-0.008684118,0.05860882,0.06298334,0.04067723,0.030814227,-0.052277375,0.018219674,0.05610343,0.06725635,-0.11335004,-0.039068975,0.042912606,-0.046001684,0.062491726,-0.019039767,-0.03601103,-0.0128931375,0.046877246,0.06473568,-0.029923102,0.05054412,-0.026424496,-0.04169146,-0.02171987,-0.035811186,0.09959873,-0.00091230945,0.040214546,0.06599461,-0.021971505,0.05756282,-0.0009799032,0.010226616,0.0691573,0.01818722,-0.036262352,0.040395495,0.025653915,-0.042121336,-0.07819436,0.03752151,-0.03998853,-0.041305795,0.05682989,0.022963498,-0.0067352983,-0.106519215,-0.0027307835,-0.011495341,0.026826046,0.07305949,-0.07894074,0.04394788,-0.018088127,0.043429017,-0.06438154,0.060479254,0.019348715,-3.988012e-08,0.02398184,-0.02626965,0.09259036,-0.036903493,0.029271828,0.022499358,0.028305197,-0.002518089,0.05159058,-0.051617414,-0.014729564,0.09881506,0.04167005,0.029720144,0.00058902084,-0.015439788,-0.054110285,0.031215243,-0.047140896,0.008492546,0.010616358,-0.006826794,-0.08113055,0.036720235,0.015949292,-0.04536275,0.0088409595,-0.02946228,-0.024066081,-0.065096095,-0.028051497,0.046239812,0.040734813,-0.06263543,-0.056141216,0.022821084,-0.02778857,-0.0031373862,-0.08337342,0.016340815,0.046438497,-0.09629506,-0.066662304,0.019488119,0.032789756,-0.0052146767,0.009437032,-0.018939395,-0.037995934,0.025868542,0.091047645,0.0003504458,0.07480548,-0.060635455,-0.08358501,0.005440831,0.022509053,-0.05914458,-0.064887196,-0.019142492,0.07174682,-0.08304329,0.14089483,0.00286243 +1.1.1.300,"Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH. ",384,0.99999994,-0.061116405,0.02058639,-0.029309314,0.03490218,0.06499836,0.07231019,-0.06597517,0.024953302,0.022783266,0.029082062,0.01810926,-0.029215282,-0.03008102,0.0009022056,-0.02356147,-0.014244906,-0.026592553,-0.011658174,-0.005700188,-0.045621306,0.0292479,-0.07415697,0.012050079,-0.030556325,0.047758915,-0.028094122,0.027984334,-0.04570557,-0.056848556,-0.049018033,-0.073363006,-0.064971305,-0.045763314,-0.025915109,-0.054215346,0.06038824,-0.048643615,-0.0855672,-0.116945535,0.031998485,-0.03588028,0.0061753416,-0.08818761,0.015776547,0.069107994,-0.076675616,0.04414966,0.07597896,0.02850604,-0.024842981,-0.06684857,0.0034687822,-0.034579944,-0.03751111,0.074434206,0.059069067,-0.03968832,-7.424258e-05,0.015193279,0.051080704,0.042899594,-0.071690544,-0.010432142,-0.021454012,0.022681348,-0.052588657,0.007370243,-0.077688895,-0.038474258,-0.06648132,-0.05082181,-0.050676793,0.0013993094,-0.03430622,-0.048283167,0.02713042,-0.06104769,-0.06875285,0.022822032,0.0016469479,0.07457208,0.028487025,-0.053712968,0.03268991,0.13661163,0.017799882,-0.020525217,-0.018936576,-0.03620053,0.07243785,0.022583086,-0.04448076,-0.0528006,0.10179528,-0.11203514,0.017152697,0.08373576,-0.0048816735,-0.0563664,-0.094837755,0.012730728,0.098812796,0.011584772,-0.020637989,-0.06282681,0.009923694,0.03256407,0.12408426,-0.05967221,0.013335837,0.09263258,0.07229447,0.011895929,-0.005329273,-0.04905788,0.119843885,-0.042637613,-0.11987894,-0.03738008,0.043503262,0.0076155565,0.021825911,0.06535208,0.042165313,0.061197065,-0.0057415445,-0.05084074,1.490725e-33,0.04460896,0.079659134,-0.020628296,0.016061677,0.011879831,-0.009401418,-0.093487635,0.013966194,-0.024621584,-0.062936775,-0.017309485,-0.007933806,0.025672583,-0.008901365,-0.014012733,0.027797515,-0.017080298,-0.03206327,-0.0011323221,-0.029308185,-0.07473969,-0.022500535,-0.01485938,-0.01108324,0.027193889,-0.0033195144,-0.046780307,0.041143134,0.012740207,0.039345656,0.054496713,-0.09773358,-0.043731313,0.009581697,0.050159283,0.050403304,-0.030560996,-0.06796781,-0.060733072,0.073832884,-0.02069828,0.05136987,0.03865409,-0.05297292,0.04963369,-0.042263124,0.0054233894,0.055375103,-0.03391999,0.055248473,0.036929112,0.013561155,0.08214614,-0.04761024,-0.028547721,0.08453088,-0.033515003,-0.005054579,-0.0028941913,0.101893015,0.019269582,0.033674646,-0.0001854844,0.08371691,0.012463644,0.035296436,-0.08887753,-0.06800622,-0.041286457,0.04250772,0.012454004,0.03306096,0.11463287,-0.05095998,0.012049937,0.058385346,0.012271306,0.08570067,0.01699944,-0.028063675,-0.014494732,0.02284973,0.0077685285,-0.030125167,0.028511766,0.061960623,0.038670085,-0.025026424,0.061197273,0.024375351,0.109853655,-0.04430615,-0.009583604,-0.11179492,-0.02024168,-1.8702673e-33,0.04617976,-0.08309636,0.06803861,-0.10360848,0.00087119953,0.08157778,-0.012093983,-0.089925036,0.014406766,-0.0825475,0.028543929,0.055320647,-0.01081469,-0.027022954,0.050532963,-0.04046594,-0.03272147,0.047530003,-0.04641791,-0.043073602,-0.025871836,0.07654277,0.036913145,0.036421485,0.01424992,0.005040747,-0.07245842,-0.00028130968,0.064152256,-0.03873272,0.03414647,0.013801119,-0.073327675,0.023422422,0.03585422,0.058574945,-0.117155716,0.0079557495,0.06459762,0.15507017,-0.024966959,-0.0023034117,-0.060703855,-0.06777333,0.053056214,0.02883906,-0.07961853,-0.060085643,0.06850115,-0.094168864,0.08952737,-0.0018736669,-0.071553715,0.0033232735,0.029298967,0.02801696,0.021715656,0.06914596,0.11161634,-0.014909424,-0.0087765595,-0.065444954,0.03960653,-0.029589357,-0.022057066,-0.014811094,0.0076929056,0.035160538,0.059046198,0.03775444,0.06861092,0.005524779,0.020752953,0.05630383,-0.0531852,-0.03392052,-0.012562668,0.036383048,-0.035375424,-0.004698102,-0.03139879,0.01697617,-0.05379385,0.0033751992,-0.005837746,0.0064144,-0.011179588,0.017741218,0.0010935854,-0.021518305,-0.03578874,-0.02710876,-0.10168832,0.052382898,0.055309493,-3.7878646e-08,0.07042373,0.0051206634,0.03441393,-0.015000424,0.02404155,0.013325267,0.04046634,-0.0060457233,0.039620534,-0.0036888332,0.03775395,0.09956982,0.059654605,0.039253883,-0.0047236346,0.0023048846,0.01944367,-0.022452584,0.0069169174,0.020003308,-0.025835501,0.02052658,-0.08653306,0.054028373,0.00032468187,-0.05942728,0.018082164,0.014016195,0.019715928,-0.06942204,0.08652528,0.018291054,0.07044046,0.027321089,-0.09238397,-0.015968164,-0.0030307628,0.10689243,-0.060445487,0.061738923,-0.06484093,-0.13676785,-0.015290654,0.039997485,-0.06775513,0.006240056,0.054870266,0.0020253153,-0.026270567,0.013193548,-0.056566294,-0.0078037777,-0.028419208,-0.05946629,-0.099323474,0.00682396,0.024560234,-0.018310485,-0.002661386,-0.09158957,0.07214061,0.04734656,0.05528991,0.013808703 +1.1.5.4,"A flavoprotein (FAD). Vitamin K and several other quinones can act as acceptors. Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.1.299 (malate dehydrogenase [NAD(P)+]).",384,0.99999994,-0.07774598,-0.045125164,-0.072407454,-0.06422287,0.08426648,0.043481648,0.022254486,0.039583024,0.06326313,0.013428461,0.07787422,-0.019645957,-0.059094705,-0.012008372,-0.07089508,-0.001434809,-0.014286592,-0.019539628,-0.061466366,-0.00044505775,-0.06686985,0.00090341124,0.008574871,-0.02132995,0.028503036,-0.011314883,0.030235427,0.009768571,-0.022583805,-0.0071585216,0.008993204,0.02974581,0.050890088,0.016450532,-0.123101644,0.062858716,0.011437706,-0.026880572,-0.031019242,0.051998314,0.03563295,-0.023346616,0.017068231,-0.04085656,0.088843666,-0.025838165,-0.034216184,0.0790522,0.0075291526,0.010089954,-0.03740029,-0.030646633,-0.0866786,0.09433262,0.027706772,0.044648066,-0.06679013,-0.039284702,-0.028350845,0.03796821,-0.050245155,-0.084875554,0.036744993,-0.020584704,0.027021803,-0.061095502,0.009248015,-0.029131081,0.032250144,-0.050428957,-0.014851947,-0.05722655,-0.019704178,0.019256763,0.01915174,0.1052965,-0.11759859,-0.025266001,0.053705636,-0.017291626,0.0036043117,-0.024620501,-0.0031892983,0.036792155,0.076307245,-0.05914946,-0.0025908374,0.03995385,-0.02761021,0.08005725,0.03506314,-0.0035654465,0.04254826,-0.013330138,-0.09146712,0.073870175,0.06047816,-0.015135095,-0.058836468,-0.039046876,-0.06264588,0.028841376,0.010367453,0.002296309,-0.09983973,-0.025484858,-0.008513508,0.055115778,-0.037967764,-0.050453246,-0.037577823,-0.07292498,0.021060372,-0.027800575,0.008577716,0.036609456,0.01756689,-0.10646232,0.012992381,-0.024102822,-0.05515652,0.07952146,0.09351721,0.0721537,0.06482556,0.017323142,-0.07623668,1.783917e-33,0.05924787,0.05435213,-0.01095949,-0.007169389,-0.00085870374,0.011935053,-0.119915664,0.072720185,0.012854791,-0.10669751,-0.08332939,0.022420598,0.049553286,-0.023652771,0.022295104,0.07117596,-0.015444097,-0.06480519,0.0532051,-0.069889665,0.041488077,0.03534131,-0.025981767,0.033137828,0.04083308,-0.018652309,-0.058094073,0.08452818,-0.009173342,0.018663727,0.022137731,-0.0491001,0.005112342,0.021652604,-0.051608738,0.057005282,-0.043908317,-0.04622753,-0.080917336,0.054626882,-0.03573372,0.014188595,-0.023222826,0.039912853,0.0151101155,-0.044595465,-0.014494505,0.046634708,-0.0030187685,0.044227954,-0.005702035,-0.023477439,0.097499326,-0.00836723,-0.064292155,0.045068216,-0.02012052,0.039946128,0.0012199393,0.019363577,-0.009208109,0.065692365,-0.022897022,0.07906899,-0.083175436,0.0019378245,-0.08309301,-0.08102712,0.0076479167,0.083978824,0.049257997,0.024467347,0.12380865,-0.015775861,0.029906087,-0.033228263,-0.029270561,-0.06585436,-0.047033314,0.060131636,-0.03726407,-0.0434082,-0.034461927,0.041131835,-0.06673156,0.005423934,0.02045686,-0.037125878,0.11360539,-0.044881202,-0.008168916,-0.023410538,-0.010118788,-0.038374092,0.07072011,-1.4287887e-33,0.0500477,-0.0786551,0.032224685,0.06639049,0.074893676,0.13268337,0.06180829,-0.08789768,0.057052918,-0.07721244,0.070326775,-0.057469204,0.0008746286,-0.054872334,0.034019474,0.0047151432,-0.11424514,0.050051305,0.03739362,0.008616911,-0.051019132,0.006051822,0.040457867,0.04584991,0.06491511,0.01743183,-0.025401425,0.008765678,-0.00825643,0.055991616,-0.032657683,0.025476137,-0.061393674,-0.017788807,-0.016025625,0.047493536,-0.040296115,0.003475757,-0.028297944,0.05625025,-0.015831647,-0.024902895,-0.0026177175,0.053354595,0.034054283,0.045553923,0.029501753,0.026163789,0.063338,-0.09057652,0.05856433,0.067948885,-0.023046328,0.09382664,0.08410373,0.08133385,0.057077583,0.08560588,0.020024894,-0.021093579,-0.008210314,-0.14261559,0.064083576,-0.022077063,0.036889896,0.020111362,0.010483533,0.14146762,0.0045397496,0.008738875,0.09122507,-0.036398057,0.047577158,0.03297767,0.032630008,-0.050592612,-0.0451363,0.035961565,-0.033844333,-0.0008575452,0.0088373255,-0.017090699,-0.06503831,0.0324796,-0.06788216,-0.035056856,-0.008304765,0.038569555,-0.035019144,0.018636314,-0.05103297,0.06654186,-0.0675177,0.039366532,0.07110042,-3.9037495e-08,0.04883132,-0.038448393,-0.010296033,0.008635797,0.088933006,0.0058117523,-0.045823373,0.004398839,0.021424228,0.016155917,0.005859556,0.10696151,-0.010118189,0.007662122,0.041730464,-0.048966624,-0.03510661,0.037387036,-0.01698839,0.02832086,-0.050720345,0.056421053,-0.0781973,-0.06081533,-0.075184494,-0.042363763,-0.035093732,-0.023816867,0.015224039,-0.04686582,0.027676025,0.0033657446,0.037502,-0.05437858,-0.05956338,0.06481704,0.007923929,-0.012588945,-0.062523074,0.07109363,-0.027590964,-0.11260857,-0.11345559,-0.005966918,-0.000679563,-0.0052082236,0.07885232,-0.0175589,-0.06897025,-0.016318334,0.03229243,0.00418103,0.059355475,-0.04591314,-0.03593393,0.01565014,-0.023322884,-0.11709237,-0.0074119684,-0.07170029,0.027870825,-0.03031458,0.110260464,0.036246065 +1.2.1.75,"Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits [3]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298 [3-hydroxypropionate dehydrogenase (NADP+)] [4].",384,1.0,-0.07659642,-0.012091721,-0.043593377,-0.018065024,0.038276933,0.023323076,-0.06370958,-0.03231808,-0.019403422,-0.0173143,-0.009094793,-0.06815614,0.002855946,-0.011587152,-0.04978757,0.024367502,-0.04305954,-0.003338003,0.034648716,-0.029641462,0.11327279,0.039972875,-0.083463416,-0.01723684,0.009191884,0.08473021,0.044777516,-0.067046456,-0.086200215,-0.03312278,0.008019904,0.006492603,0.033994067,-0.10426244,0.058397274,0.13308384,-0.043103952,-0.0623174,0.07779867,-0.04024321,-0.0031228657,0.0043304255,-0.015426755,-0.022514129,-0.07905085,-0.0276657,0.031146655,-0.022412477,0.06279343,-0.082007304,-0.08794735,-0.013671303,-0.0980705,0.017335255,0.033757187,-0.024739623,-0.009932163,0.03079369,0.054354977,-0.087194026,0.020281136,-0.013512854,-0.0006059581,0.026264247,0.031119922,-0.027416583,0.011718139,-0.068429895,0.033668254,-0.024283458,-0.0674027,0.028542858,-0.00028249013,0.009474172,-0.014372455,0.06742356,0.027858563,-0.06851693,0.07466493,-0.029952163,-0.013849111,0.0268903,0.08526369,0.075808965,0.0034391168,-0.087366275,0.10540957,-0.017944992,0.04035223,0.053948645,0.059265964,0.040050123,0.053844735,-0.0069352356,-0.06537285,0.104939684,-0.03177959,0.028521538,0.02337257,-0.058249816,-0.004456421,0.022184419,0.0009631826,-0.10581259,-0.044634357,0.023185963,-0.04085724,0.10739837,0.0907374,0.019979406,-0.0063102534,-0.0031913954,0.0102761,-0.01188641,0.0105251325,0.14296916,0.02496695,-0.06649817,-0.06761221,-0.0016051824,0.02749602,-0.024308879,0.029951332,-0.011778713,-0.047454957,0.05411611,-0.10829121,5.2606862e-33,0.06917044,0.008163117,0.00064152246,-0.024979006,0.005313808,-0.085312046,-0.104491904,0.057398364,-0.04631084,-0.011373601,-0.051939104,-0.04707021,0.00345659,-0.021460302,-0.05417647,-0.076476306,-0.028897552,-0.008769872,0.038601212,0.0801583,-0.03726725,0.06770754,0.038190033,0.0009724681,0.012908569,0.040772345,0.059271995,-0.030678416,0.064083144,0.024614409,0.0468026,-0.15501931,-0.08690026,0.005502577,0.11444805,-0.028147722,-0.020928066,-0.021401701,-0.055813983,0.021094479,-0.046139296,0.03992631,-0.031949162,-0.046325326,0.058859963,-0.052884314,-0.03533231,0.05547656,0.01511219,0.10572317,0.0075429007,-0.023446962,0.04952752,0.028676156,-0.08299513,0.036709774,-0.014434742,0.009917345,0.057512168,-0.0052648773,0.031502847,0.0861107,0.030672858,0.01644328,0.03231548,0.029052678,-0.017691987,-0.06554847,0.03394328,0.017613545,-0.06871296,-0.043370612,0.042303428,0.015229877,0.010750692,-0.058682766,-0.014971638,-0.03631949,0.032568954,0.062116172,-0.050530862,-0.0024425176,0.05083912,-0.033145864,-0.036645528,0.027567875,-0.05462448,0.03821326,-0.046836775,0.07364448,0.07117543,-0.050745342,0.0075144945,-0.01893028,-0.042203374,-6.0717788e-33,0.11788278,-0.08772273,0.043583833,-0.120971926,-0.08882295,0.06924973,0.052533083,-0.04352624,-0.010499428,0.00079212297,0.09122986,0.071810156,0.016147304,-0.04134127,0.02343733,0.009687713,0.05739824,0.06607432,-0.078191094,-0.010414159,0.07089867,0.1015149,0.0030024806,0.03590633,0.0032807454,0.029985465,0.06861343,0.07286293,0.03817648,0.06778879,0.017290868,0.04725337,-0.04218821,-0.043033615,-0.024190098,0.021954542,-0.058114186,-0.049440276,0.02477449,0.07834356,-0.01081656,0.023756495,-0.03373445,0.05168022,0.041134894,-0.010558616,-0.09575997,0.050941,0.031842943,-0.010350613,0.026936382,-0.010420722,-0.07647893,-0.015413144,0.0041315896,0.011255401,0.0052971262,0.034713205,0.020432021,-0.028677382,-0.07012175,-0.0495836,0.08149362,-0.024425428,0.04089369,0.14784423,-0.03156966,-0.009010563,0.02211998,0.009680511,0.028046954,-0.047763918,0.008798231,-0.023645993,-0.010554115,0.011431262,-0.02709829,0.036498353,-0.0011475132,-0.012557534,0.023094408,0.02990702,0.030575754,-0.06534307,0.0050851037,-0.156842,-0.0008888196,0.03290194,-0.035455815,0.010722084,-0.048313066,-0.017313842,0.0007195571,0.028510924,0.09002738,-5.0852645e-08,-0.062104393,-0.03257098,0.073848315,0.018564744,0.02051444,0.03548546,-0.018914465,-0.020668888,0.06430132,-0.03370347,0.065927684,0.008529488,0.040540196,0.015696036,0.0023349815,0.0046332343,-0.043937024,0.01499105,-0.042733137,-0.005475418,-0.048206516,-0.07594612,-0.16216147,0.04821775,0.04351812,-0.08148195,0.06494812,-0.038400535,0.0047742017,-0.050582886,-0.0029780238,0.062282164,-0.015895087,-0.047027655,-0.03840345,-0.024593491,-0.070754334,-0.016746338,-0.025530467,0.011956721,0.00069123774,0.035312384,-0.027978452,0.02265882,0.0060142935,0.014770897,0.035643775,0.08716227,-0.08792161,0.0022661658,0.04469274,0.017129404,-0.039023243,-0.030738583,-0.06760648,0.018808618,0.050742477,-0.09211051,-0.06301501,-0.010667943,-0.020923333,-0.029369991,0.08120781,-0.06549788 +1.2.1.76,"Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation [1], and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].",384,1.0,-0.017048499,0.020058345,-0.06920578,0.019745728,0.07028384,0.05239209,-0.10555981,-0.03942189,0.006162177,-0.0364483,0.00093427906,-0.05603334,0.040254485,-0.005683914,-0.0714397,-0.055452865,-0.012632905,-0.02075974,0.030144617,-0.031951897,0.086504534,0.010242647,-0.030024197,0.040151704,0.09967822,0.043067116,0.00069957844,-0.045449506,-0.0658489,-0.03161143,-0.012453907,-0.03851195,-0.0074898535,-0.06815439,0.09780918,0.060532764,-0.07255135,0.05318754,0.103762224,-0.005779699,-0.0008377219,-0.030035125,-0.047415778,0.0032897193,-0.104263954,0.006683144,-0.0032745423,-0.014674889,0.013045271,-0.03562419,-0.07748353,-0.06211427,-0.023470435,0.03392874,0.035296105,0.0019465075,-0.021517541,-0.013084,0.037375312,-0.012392835,0.034315947,-0.063261144,-0.048033696,0.032911118,0.033360936,-0.059478417,0.04093102,-0.023512147,-0.02143721,0.00028109286,-0.05706676,0.0008568702,0.024590578,0.039264474,0.074244,0.062972754,-0.006074524,-0.08565978,0.044171892,-0.017975084,0.027468987,0.059130486,-0.0035728475,0.035894338,0.025397252,-0.023209888,0.055787742,-0.027536774,0.041430514,0.033432417,0.02078152,0.026901294,0.0197634,-0.06312313,-0.124228984,0.085773714,0.021306602,0.042409018,0.049336083,-0.0534221,0.013074671,0.057311278,0.009655185,-0.14140719,-0.04807273,-0.019610628,-0.009858271,0.12581088,0.022150226,0.009338307,0.004849055,-0.023803005,0.02113725,-0.019909937,0.011591982,0.12873158,0.09960357,-0.0009086395,-0.09988225,-0.058757998,-0.018944507,0.0064635617,0.0737153,0.001830071,-0.010321058,0.07634645,-0.114739835,3.7560696e-33,0.09608798,-0.000904631,-0.016547607,-0.01860382,0.05410999,-0.07139022,-0.12234485,0.075796284,-0.02441299,0.0013492393,0.013125676,-0.068217665,0.03583502,-0.012552549,-0.04137304,-0.0767365,-0.009782597,-0.039653104,-0.014704191,0.014972113,0.018295191,0.025426844,0.03835674,0.0638945,-0.0157603,-0.020868879,0.010142104,0.04659627,-0.02496363,-0.001932897,0.075511195,-0.070671014,-0.10986425,-0.03779258,0.121341914,-0.08491197,-0.040884506,-0.035666756,-0.066308044,0.0762362,-0.061539315,0.08121187,-0.023373924,-0.04865824,0.02929337,-0.06949173,0.003648309,0.14444368,0.046888202,0.06669536,0.029422296,0.002457187,0.08710739,-0.029671604,-0.039259136,0.095528245,0.01140446,-0.030461857,0.06631757,-0.015283354,0.004450565,0.035371028,-0.025918378,-0.0008835916,0.014141826,0.0015751364,-0.07838756,-0.02595103,0.048994787,0.050972838,-0.053651307,-0.013788711,-0.040239673,0.061524045,0.05843895,-0.011028294,-0.058579963,-0.036879405,0.03573275,0.038586363,-0.034080118,-0.01051124,0.036189154,-0.033814274,0.00078496546,-0.031830836,-0.050442718,-0.022307744,-0.014286026,0.017186284,0.01373532,-0.05673294,0.019842917,-0.017375832,0.0018630315,-4.6989347e-33,0.12156675,-0.10937863,0.06772369,-0.094223246,-0.0782947,0.051707994,-0.024081832,-0.025320452,-0.018262949,-0.025120169,0.100733094,0.058000658,0.079548866,0.037647862,0.047417447,-0.021143736,0.01569323,0.020331362,-0.002565279,0.009768842,0.046960115,0.11854443,0.015423418,-0.011027896,0.082530804,-0.03523837,0.025147852,0.099146485,0.033771887,0.08245884,0.004633678,0.0058517638,-0.0341612,-0.052345764,-0.047073815,0.040467434,-0.07087044,-0.008716677,-0.0013532202,0.0720217,-0.01871131,0.0014965101,-0.059470538,0.0454788,0.04147959,-0.0073643127,-0.113929085,0.04360059,0.057278834,0.009660617,0.016921988,-0.024483075,-0.04376392,-0.04799296,0.03184963,-0.024332672,-0.030738708,0.00015834282,-0.01019239,-0.07140891,-0.044978995,-0.027594736,0.050221056,-0.009014038,0.062050864,0.05226966,-0.042022288,0.016982451,0.02779643,-0.062733024,0.035475988,-0.023709683,-0.013922669,0.0029649308,0.0082769245,-0.05028655,-0.032332033,0.028447697,-0.041715354,0.041329622,-0.020236474,0.006506074,-0.018850062,-0.09669593,-0.046734292,-0.068145335,0.0014586753,0.028186193,-0.06967789,0.048327725,-0.073800825,0.019935895,0.022134243,0.09924568,0.038512472,-4.088051e-08,0.0034147939,0.01365368,0.09857225,0.015968284,0.013705046,-0.002806176,-0.0241334,-0.08020321,0.020804388,-0.014621524,-0.011546219,0.08520514,0.09514022,0.010104336,-0.01343008,-0.00756693,-0.047991592,0.052442,-0.04230481,-0.03648229,-0.024412112,-0.06584286,-0.08771292,0.10394303,0.05975664,-0.06537538,0.051004376,-0.022304526,-0.024056379,-0.10905469,0.0028737616,0.028611703,0.089187324,-0.040865317,-0.030686244,0.036954675,-0.09311969,-0.021652471,0.0019149921,0.051905677,0.026034418,-0.011828633,-0.05042939,0.022534076,-0.0715432,0.025705596,0.0125037385,0.06589459,-0.083875574,-0.005377503,0.017612966,-0.022401305,-0.013941405,0.031141013,0.022322439,0.019732296,0.049646854,-0.046652094,-0.036775094,-0.022746079,-0.0072749173,0.017454183,0.12566641,-0.09165544 +1.3.1.84,"Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA [2]. Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16. Contains Zn2+.",384,0.99999994,-0.07017795,-0.049520962,-0.022241699,-0.031384625,0.06705848,0.01598674,-0.09850887,-0.0305428,-0.011399822,-0.0019155146,-0.0033820367,-0.121155396,-0.039656293,0.02964869,-0.0639113,0.037805945,-0.066163816,-0.033997577,0.07795463,-0.019106338,0.07576537,0.041184995,-0.034548804,0.043367293,0.0061396332,0.03678271,-0.018301548,-0.038945425,-0.04847349,-0.020625364,-0.0013830563,0.019372115,-0.014248405,-0.04693932,0.07594236,0.08172795,-9.878831e-05,-0.056513693,0.07351337,0.010538797,0.041950654,-0.006607232,0.009090865,-0.044331487,-0.025037099,0.0023040366,0.06204814,-0.01153294,0.0430345,-0.08825627,-0.08614536,-0.09804535,-0.0749244,0.034301165,0.033485923,0.055584326,0.0027136302,0.026546316,0.074746415,-0.008076591,0.08050057,-0.040014714,-0.015737953,0.031775087,0.017145053,-0.028183028,0.035773583,-0.04817789,-0.008042356,0.013969786,-0.09123678,-0.02561199,-0.015151359,-0.013946697,-0.0018633084,0.06567566,-0.03737096,-0.09571599,0.03285382,-0.06070006,-0.04667278,0.00032834438,0.034384087,0.040282696,0.021988966,-0.026078561,0.026316136,-0.032923225,0.103174515,0.03046432,0.012462131,-0.0075997463,0.07220523,-0.03435378,-0.11615173,0.07120237,0.06506113,0.05457819,0.085620195,-0.02041583,0.043839317,0.03579105,-0.02141688,-0.15046939,-0.042381868,0.031011602,0.030989768,0.15872014,0.059522063,0.034019567,-0.067408875,-0.035530966,0.0745993,-0.03636004,-0.043959413,0.12651363,-0.017139772,-0.028477076,-0.08165448,0.031645264,-0.0113482615,-0.015956972,0.052724604,0.016454363,-0.04081604,0.022594653,-0.12378492,5.9531358e-33,0.10960205,0.03765057,0.022309039,-0.033281334,0.024985982,-0.036550943,-0.13061443,0.015341464,-0.029880643,-0.044366293,-0.046264663,-0.046226144,0.00258996,0.00798762,-0.057672672,-0.07073636,-0.024109676,-0.009004628,0.0034276075,0.051786717,-0.029485893,-0.016255602,-0.02613207,-9.986224e-05,0.026488857,-0.012685497,0.054761324,0.021067627,0.013752542,0.028565003,0.027982853,-0.104213335,-0.105999514,0.011977106,0.11585236,-0.0792761,-0.02181391,-0.014677629,-0.09774936,0.04740426,-0.026545584,0.061543122,0.01057263,-0.07664851,0.051125295,-0.046588007,0.0020644758,0.105501965,0.047100656,0.039123714,-0.0010329759,-0.0040003243,0.058111936,-0.0055692918,-0.09464593,0.013112234,0.0058756187,-0.025617732,0.07056498,-0.019758593,0.031068224,0.053391814,-0.008541001,-0.015397656,-0.046474017,0.10544821,-0.015981933,-0.008694906,0.04427243,0.046266753,-0.059991345,-0.009909836,0.021134768,0.07145578,0.060332805,-0.07084252,-0.07157665,-0.09061659,0.041547433,0.017305588,-0.06585493,-0.033122655,0.053464826,-0.0014520887,-0.03491607,-0.012475367,-0.012880668,0.03475012,-0.00068312814,0.080353074,0.05643932,-0.10761804,0.05104358,0.0037052913,-0.011225323,-5.9395694e-33,0.060596105,-0.07081013,0.027854508,-0.13375755,-0.081957385,0.07588254,0.014486216,-0.020860568,0.057601973,-0.020843437,0.12327105,0.05073799,0.02842645,-0.03623405,0.032521017,0.010608641,0.017782532,0.021219445,0.020894043,0.00073100405,0.124303855,-0.018917998,-0.024902238,0.03102018,0.041682087,0.0501407,0.029670583,0.06647848,0.087080106,0.0789508,-0.019400941,-0.0076464675,-0.045680184,-0.0488775,-0.061251976,0.03959475,-0.057571515,-0.0046066935,-0.010037599,0.01970603,0.023696093,-0.0095973825,-0.039454643,0.08291953,0.016399095,0.02539511,-0.0845161,0.02475916,0.043160994,-0.024212971,0.016407473,-0.0037024827,-0.0041960278,-0.058209717,0.054428842,0.058329366,-0.005764703,0.052207936,-0.056473795,-0.04742366,-0.09631176,-0.020440983,0.06629365,-0.013841904,0.034325104,0.096348315,-0.052793473,-0.020748135,0.00065222866,-0.018224325,0.06704427,-0.037308633,-0.0015272591,-0.002988811,-0.020155435,-0.0330137,-0.038216274,-0.038241997,-0.03326732,-0.010779031,0.010048505,0.0016664063,0.048945352,-0.043595687,-0.017209532,-0.118992984,0.03978786,0.03203826,-0.06320923,0.018263306,-0.018244348,0.026611129,-0.0042642583,0.038768377,0.056967605,-4.4942894e-08,-0.0029614067,-0.04632733,0.09869603,0.010554935,0.0032168103,0.030479249,0.031139862,-0.008990038,0.05891028,-0.0363395,0.044741455,0.06634506,0.122055605,0.019048374,-0.0152323665,0.015670339,-0.034228235,0.007545882,-0.05315242,-0.015995309,-0.019114127,-0.049819462,-0.079657815,0.016329926,0.024862882,-0.062196083,0.015951682,0.06728695,-0.05379276,-0.07849992,0.0075511187,0.023763506,0.0068055317,0.00091282424,-0.051670104,0.013757591,-0.08316425,-0.051732708,-0.055569097,-0.0038492267,0.03191563,0.021075644,-0.053224307,0.03613025,0.027805869,0.018807618,-0.0061822203,0.063926145,-0.030548371,0.0018240657,0.051104788,0.024343597,0.0065735467,-0.049839273,-0.034713257,0.0014609545,0.04747498,-0.053609263,-0.06632147,-0.0010926168,0.021890014,-0.017113725,0.111887515,-0.09168556 +1.13.12.16,"Previously classified as 2-nitropropane dioxygenase (EC 1.13.11.32), but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Neither hydrogen peroxide nor superoxide were detected during enzyme turnover. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. ",384,0.99999994,-0.039951302,-0.053983495,-0.08970628,-0.04261209,0.10208998,0.018699659,-0.10228798,0.011548849,0.012570175,-0.029417591,0.029258536,-0.046178766,-0.11115076,0.06206184,-0.10437831,0.06815361,-0.022090347,-0.02367199,-0.012621729,-0.025469314,0.02430565,0.034175344,-0.0017626197,-0.035977136,-0.026159935,-0.010476139,-0.021659492,-0.047728524,-0.019587947,-0.055629253,0.040130176,-0.035413917,0.0025644656,-0.04803786,0.012313789,0.05553395,-0.025412392,0.0015593545,0.024909386,0.0151789095,0.008318502,0.01012526,-0.04566354,-0.012728636,-0.0079588955,0.021681428,0.050051015,-0.032834746,0.083926775,-0.053707927,-0.08490773,-0.08889116,0.014122202,0.016537001,0.037960887,0.0038826691,-0.033244558,-0.041283507,-0.014280674,0.016303746,0.03356802,-0.028498,0.07767535,-0.010102577,-0.0065187444,-0.008808745,-0.0153709855,-0.065855704,-0.05618836,-0.03617014,-0.05190547,-0.009641365,0.0054340134,-0.049218558,-0.04107694,0.06272438,0.005926267,-0.046775196,0.04431039,-0.048102934,-0.029754847,0.037900474,0.07024086,0.023065316,0.029908981,0.003744543,-0.0011279053,-0.0024928362,0.032299217,0.068706,0.0028673878,0.05258856,0.07670034,-0.02880793,-0.0037788483,0.06935769,0.015920922,0.08201885,-0.03145519,0.010367158,-0.003454413,0.0145141,-0.051078074,-0.041208096,-0.098072425,0.0741331,0.026051348,0.04616305,0.11660386,0.11649724,0.022083517,0.013975089,0.018803392,-0.030725356,-0.029666783,0.04107049,0.0038435038,0.03324814,0.016328081,0.013569912,-0.0001719777,-0.008233765,-0.05818034,-0.00661343,-0.055967227,0.096794926,-0.031691387,4.3175456e-33,0.03974555,0.043848667,-0.063486256,0.0080793165,-0.012221795,-0.071334384,-0.11253384,-0.01826324,0.015306529,-0.034107395,-0.021666456,-0.0077886293,-0.02432028,-0.075909056,-0.033757824,0.016571702,0.061222453,-0.0022997877,0.016878687,0.07460169,0.02809777,0.0030073642,-0.07774985,-0.01217785,0.047232933,0.005679103,0.028108073,-0.011414516,-0.022215668,-0.055453867,0.010645635,-0.10392007,-0.04805245,0.047585174,0.07496716,-0.08102043,0.017244376,-0.004020966,-0.043606993,-0.024471337,0.00027289017,0.07148453,-0.08016508,-0.069661364,0.06217042,-0.040194195,-0.020658536,0.13609499,0.060727105,0.067788415,-0.02579284,0.015973741,0.046219047,-0.009731263,-0.01996107,0.02510067,-0.0036003205,0.044222657,0.18353239,0.03368269,-0.10003835,0.0074347625,0.019251047,0.015855998,0.025039488,0.032183282,-0.08700717,-0.04250592,0.08942544,0.049666964,-0.05284184,0.052265506,0.023548096,0.019979168,0.022320429,-0.09921731,-0.021627003,-0.019404607,0.0421994,0.06355819,0.08192588,0.014299119,0.02089309,-0.0642486,-0.028677035,0.026005842,-0.08060543,-0.00605884,0.0053428817,-0.011775888,0.08333389,-0.09482458,-0.014609577,-0.024668535,0.042126864,-4.3190575e-33,0.044660576,-0.037022747,0.0037069756,-0.060693547,-0.027751189,0.12760177,-0.05250825,-0.016123584,-0.062136415,-0.03315945,0.05422693,-0.020026548,0.0072427266,-0.02970618,0.016260555,0.017696127,0.0024818631,0.10338653,0.048784025,-0.03931391,0.0002575577,0.07851137,-0.041860644,0.021089043,0.06708856,0.048365556,-0.019203976,0.09028574,0.033327654,0.023411725,-0.027841322,0.051449947,-0.065392375,-0.007449352,0.05340099,-0.00076807296,-0.10831238,0.037698418,0.0037778995,0.04422876,0.0317228,0.0391014,-0.009311119,0.10360471,-0.09688057,0.07058833,-0.18421927,0.03616682,0.050880168,-0.081377245,-0.002458022,0.03276535,-0.06556079,-0.0076496676,0.04074706,0.055126358,0.057787728,0.03962596,0.05022853,-0.009773301,-0.051834207,-0.07133072,0.04721498,0.018796543,-0.07090674,0.048074238,-0.055637766,0.056112085,0.047643967,0.018077124,0.0058259345,0.04018352,0.118463874,0.014923425,-0.08652231,0.018658055,0.072988085,-0.066309,-0.027273918,-0.008388146,0.03405313,0.027479442,-0.013039268,-0.09070298,-0.014315396,-0.0364629,0.05399439,0.041913632,-0.027104167,0.027314786,0.06293129,0.042834416,-0.04481736,0.02441955,0.036399584,-4.4587992e-08,0.03377374,-0.0441036,0.13875778,-0.01374327,-0.02574113,-0.0029565068,0.0736805,-0.016245749,0.051547468,-0.00030336576,0.033354454,0.043067466,0.015499249,-0.020793777,0.033584133,0.018179031,0.017981663,0.025989002,-0.011781272,0.08154207,-0.001094249,-0.004594579,-0.09091752,-0.019896504,-0.028106265,-0.088619396,0.07134942,0.04240487,-0.012754749,-0.059755597,-0.09980739,0.056233495,0.025749173,-0.054998867,-0.084705666,-0.020394294,-0.03469753,-0.011039783,-0.119553156,-0.041197352,-0.019582916,-0.031103423,-0.017225247,-0.009827604,-0.06500674,-0.04592441,-0.016578538,0.00440132,0.016573345,-0.01189655,0.06660326,-0.015814437,-0.004130206,-0.050635844,-0.114452645,0.038693685,0.016051443,-0.011533332,-0.08549131,-0.054317873,-0.0035132703,-0.052829076,0.089292824,-0.071553245 +1.13.12.18,"A luciferase from dinoflagellates such as Gonyaulax polyedra, Lingulodinium polyedrum, Noctiluca scintillans, and Pyrocystis lunula. It is a single protein with three luciferase domains. The luciferin is strongly bound by a luciferin binding protein above a pH of 7. 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+1.14.14.7,In Lechevalieria aerocolonigenes the enzyme catalyses the initial step in the biosynthesis of rebeccamycin [2].,384,1.0,-0.029302785,0.023408059,-0.08496566,-0.0362886,0.0340824,0.016524358,-0.07488176,0.054640707,0.062343083,0.0057007265,-0.023964839,-0.05015765,0.07563553,-0.0457538,-0.04807857,0.038615588,-0.056359023,0.048944954,-0.05182859,0.036889568,0.08864945,-0.046632145,-0.0074644173,0.04522706,0.100315474,0.04560254,0.029397957,0.09312414,-0.054879148,-0.042382225,-0.0031771336,-0.06187297,0.035135463,-0.044034146,0.10554349,0.004868277,0.013262348,0.016319873,0.13790278,0.011018183,-0.026049223,-0.058537696,-0.03519594,0.03808326,-0.075204186,-0.018161958,-0.030440802,0.047296483,0.047473587,-0.014327119,-0.0835129,-0.03461807,-0.060046002,0.007946973,0.088870764,-0.016277255,-0.033501986,-0.045284368,0.012536527,-0.025536843,0.052459195,-0.059337966,-0.014312232,0.006003738,-0.030119386,-0.09934886,-0.010669266,-0.012261557,0.116812356,-0.015937282,-0.06573925,-0.059524577,-0.0013865832,0.077823356,0.0448337,0.0037758052,-0.010187058,-0.032169446,-0.05013126,-0.017363261,0.08222164,-0.034529734,0.046856757,0.0726176,0.0044897287,0.030628784,0.06161224,0.0037204304,0.069457926,0.05122852,-0.029670613,-0.0070233843,0.033070423,-0.074341804,-0.05182642,-0.027236136,-0.020374177,0.022429885,0.052855756,0.0035520368,-0.004377584,0.0025065874,0.039315283,-0.05501196,-0.056265652,0.0004108694,0.008409119,0.07693937,0.0039253705,-0.07153176,0.022445561,-0.05642486,-0.03513384,-0.01106272,-0.06540877,0.14249346,0.08272958,-0.10224243,-0.13284218,-0.060928226,0.008941061,-0.036999423,0.0042120814,-0.0009164205,-0.056607418,0.032530356,-0.06450689,6.953034e-36,0.038612586,0.07261797,-0.06282232,-0.0039496957,-0.021847345,-0.004532167,-0.050705485,0.0053216536,5.6551897e-05,-0.034308195,-0.109426424,-0.1177589,-0.056375407,-0.025104022,-0.028608574,-0.0042214417,-0.007180957,-0.022643287,-0.014795418,0.05199257,0.06303456,-0.0013151,-0.03997329,-0.016273532,0.045734756,0.047404006,-0.0067775003,-0.0028904881,0.08437701,-0.0013265909,0.019030308,-0.031098342,-0.07319648,0.021047585,0.07868016,-0.008852606,-0.01182184,-0.028046424,0.06603771,0.051600076,-0.065068856,-0.0043823193,0.021152113,-0.038123816,0.018223401,-0.020989021,-0.04531797,0.06491111,0.10478232,0.013795806,0.041016832,-0.0014235311,0.10946432,0.06868692,-0.06417811,0.015964976,-0.0115300715,-0.029809473,0.0005658623,-0.0019729105,0.012430024,0.016776528,0.026732739,-3.3047693e-06,0.12711094,0.0035675876,-0.049390674,0.035515565,0.017121205,0.08528938,-0.06463878,-0.037133653,0.05709023,0.011548177,0.072759,-0.005329397,-0.02494934,0.0036950486,0.016460743,0.0540109,0.061315484,0.0064932234,-0.040454082,-0.06391745,-0.0754056,-0.022001188,-0.015157352,-0.05627038,-0.051534574,0.078485325,0.011386556,-0.07191792,-0.028171107,0.062182263,-0.03581867,-2.3457353e-33,0.10034709,-0.0791939,0.05970623,-0.01752986,-0.031478696,0.106869444,-0.026928041,-0.028494382,-0.04425196,0.027730357,0.04802797,-0.038825206,-0.021528432,-0.013887712,0.023804087,-0.019631816,0.010152453,0.0773783,-0.029713562,0.0033593075,0.00964975,0.045948654,-0.043658867,-0.02423019,0.06408695,0.02341768,0.116750866,0.045548305,0.055183038,0.054896828,-0.021530325,0.039142273,-0.02975693,-0.015900098,-0.009858119,0.10335213,-0.022274237,0.0411859,0.074785165,-0.02935342,-0.015910948,-0.0047623403,-0.012414806,0.08951735,0.09736095,0.007861211,-0.027837578,0.080588326,0.03852073,-0.06737163,0.02974978,0.030342106,-0.07074537,0.014954237,0.032576516,0.021278141,0.082320295,-0.028335989,0.0023159469,-0.07983857,-0.10178602,-0.06670695,-0.013934481,0.00498184,0.0015934163,0.08921379,-0.063087806,0.0071384683,0.06117417,0.017814526,0.012510083,-0.024861788,-0.014320002,0.0011132667,0.014626864,0.03708065,-0.05055361,-0.06520227,-0.014656286,0.018409545,-0.056107283,0.018714026,0.047417827,-0.0639147,-0.02440677,-0.06846526,0.05484598,0.01464003,-0.034873452,-0.015181899,0.036562666,0.009606824,-0.007758537,0.03643081,0.034154467,-2.6483177e-08,0.09436922,-0.041140996,0.08759345,-0.014063353,0.0071718874,0.032196205,-0.06352362,-0.007728276,0.037881013,0.01749659,-0.06862102,0.080821395,0.008483744,-0.047122,0.02520064,-0.011867438,-0.03825683,0.04693354,-0.025730353,0.018366076,-0.05668403,-0.059979815,-0.112071484,0.008973071,0.005479121,-0.050833825,-0.00044043275,0.0031588604,0.028196517,-0.040712684,0.035234943,0.03577032,-0.06792515,-0.056590807,-0.11799227,-0.037064347,-0.05172463,-0.032929927,-0.008723205,-0.121616326,0.11406232,-0.021759596,-0.10199077,0.02996474,-0.057566416,0.029217985,-0.024864303,-0.02441512,-0.08084929,-0.023110295,0.046621956,-0.0052356753,0.030648556,-0.032676958,-0.11226712,0.032909244,-0.0022668424,-0.03462959,-0.010790663,-0.04290092,-0.07698521,0.012047928,0.13619646,-0.054744437 +2.1.1.163,"The enzyme catalyses the last step in menaquinone biosynthesis. It is able to accept substrates with varying polyprenyl side chain length (the chain length is determined by polyprenyl diphosphate synthase)[1]. The enzyme from Escherichia coli also catalyses the conversion of 2-methoxy-6-octaprenyl-1,4-benzoquinone to 5-methoxy-2-methyl-3-octaprenyl-1,4-benzoquinone during the biosynthesis of ubiquinone [4]. The enzyme probably acts on menaquinol rather than menaquinone.",384,1.0,-0.054640412,0.00091593654,-0.077348456,-0.025314929,-0.059116486,0.056277562,-0.08702308,-0.012436006,0.011774509,-0.017808076,0.0056586093,0.014348801,-0.059151746,0.0058456752,-0.046390466,0.03485293,-0.10554259,0.003570612,0.03140464,-0.007259368,0.088297985,-0.04819083,-0.07514023,-0.08189001,0.032525193,0.002339321,0.021040289,0.030300595,-0.025248865,-0.0022708722,0.053006023,-0.04715967,0.02105466,-0.09151184,0.009148323,0.08869061,-0.011795571,-0.061317198,0.058744416,0.072758794,0.05896125,-0.022446746,-0.013565975,0.07624955,0.08422316,0.02636993,-0.009358435,0.03568596,0.07339412,0.0016376576,-0.06647802,-0.0004505217,-0.00013793327,0.013171831,0.039148074,-0.0072615016,-0.04988561,0.018236855,0.017168384,0.0021698803,0.027041357,-0.015508788,0.022790683,0.019931152,0.024350716,-0.026258659,-0.089640744,-0.047828496,0.029282749,0.01774116,0.0063939504,-0.048783008,-0.107490934,-0.026252592,-0.058448624,0.036580924,-0.06589242,-0.038141903,0.019971188,-0.035963483,-0.0027075897,-0.0069296067,-0.0045769117,0.100468434,0.018311178,0.05275661,0.03969461,-0.032902587,0.049847938,0.10869544,-0.014185847,-0.05969871,-0.0035921044,-0.04491993,-0.033005208,0.012111104,0.02134869,0.10376156,-0.039058845,-0.045517158,0.052507862,6.695861e-06,-0.08174369,-0.13289681,-0.045047544,0.041546676,0.016396401,0.12127144,0.042067625,0.023130137,-0.07967985,0.03881074,-0.036550492,-0.021279259,-0.022909494,0.03507911,0.041286238,-0.03149294,-0.08652304,0.017268267,-0.045645006,0.036701687,0.05730542,0.011056258,-0.0061385506,0.04531419,-0.06045012,3.257458e-33,0.021747317,0.028411511,0.019368375,-0.03870663,-0.017272873,-0.001799505,-0.066864304,-0.0067751547,-0.05292075,-0.022294037,-0.022318458,-0.008195148,-0.041564297,0.017458756,0.02822186,-0.011503504,0.05557736,-0.055019524,0.06657593,-0.0198121,-0.042606156,0.0120151555,-0.038809504,-0.06294075,-0.005589566,0.04339886,-0.027142536,0.019411368,-0.039667167,0.015126942,-0.06411413,-0.032789364,-0.08588114,-0.015114457,0.027188286,-0.037962418,-0.048526052,-0.040964067,-0.011958024,0.053622514,0.030032713,0.010078296,-0.048628233,-0.011213458,0.08618762,0.028519604,-0.031665914,0.117707215,0.05545647,-0.016608804,-0.0042960006,0.065852836,0.13040525,-0.008582915,-0.07455423,0.007893064,0.025552405,0.010847159,0.0040938007,0.048667524,-0.0043011536,0.039267305,0.015847804,0.04574609,-0.0040115425,-0.030955363,0.0038580357,-0.0017437491,-0.032768756,0.06104556,-0.0058018975,-0.02461353,0.0071524153,0.04000447,0.048344735,-0.018577302,-0.07074252,-0.018091092,0.097520754,-0.08022885,-0.004408135,-0.013155021,-0.0010203939,-0.05229808,0.0041324566,0.048526924,0.023553194,-0.08409786,-0.025314232,0.06209368,0.05920091,-0.086435966,-0.02211961,0.031990916,0.05000846,-5.315485e-33,0.043511134,-0.094818145,0.017927088,-0.105187066,-0.042540405,0.039063737,0.009646224,0.023936424,0.002863998,0.041819267,0.060380228,-0.06871991,0.035541665,-0.00017869171,-0.049945343,-0.022249663,0.00432254,0.085506454,0.038721863,-0.06946732,0.07461773,0.05998276,0.02368227,0.013958724,-0.000955377,0.020966848,0.019227555,0.038315915,0.05466348,0.10164508,-0.012241968,-0.025464153,-0.069156475,-0.012033705,-0.0021899412,0.05602485,-0.061764903,0.08377337,0.12773238,0.029516866,0.021341242,0.012012041,-0.042152748,0.00773484,0.07395213,0.07655416,-0.08071124,0.08647503,-0.04521473,-0.082264006,0.04073703,0.024316354,-0.046896283,0.013169263,0.044603832,0.031666234,0.043182764,-0.110497564,0.025443172,-0.023806518,-0.08342833,-0.06234942,0.026275134,-0.0057734232,-0.009635791,0.1068336,0.050629616,0.03553037,-0.026413321,-0.048055045,0.10240403,-0.04956043,0.025814401,0.06931081,-0.037767183,0.037517257,-0.02097436,-0.07668653,0.027617756,-0.04242471,-0.006511874,-0.049439345,0.008705003,-0.0033302414,-0.063355446,-0.09834747,0.08983817,0.064474635,-0.050453756,0.10813144,-0.00997419,0.05290935,-0.05587816,0.03206089,0.04245246,-3.917551e-08,0.047780152,-0.04080896,0.120637305,-0.069136985,0.02390134,0.009002537,-0.0772195,0.002924032,0.11024357,-0.028337616,-0.02497703,0.009231171,0.019469233,0.025438603,0.037195437,-0.0011004641,0.026296446,-0.014687738,0.0058584413,-0.049860403,-0.1004046,0.010159067,-0.08695689,-0.02310196,-0.028823521,-0.098839834,0.041268956,0.06556636,-0.013480981,-0.036192313,-0.002023449,0.053435054,-0.043168023,-0.017674904,-0.09458464,0.028863953,-0.07846156,-0.0677402,0.08549022,-0.06417752,-0.07242486,-0.09678974,-0.0012557862,0.055688255,0.029778263,0.0042386125,0.037583403,0.042232867,-0.05244033,-0.00214138,0.035340935,-0.03004379,0.085456975,-0.120124035,-0.05978833,0.020429349,-0.050475065,-0.041263387,-0.009775493,-0.10517952,-0.016592724,0.027574075,0.13146973,-0.02935014 +2.3.1.188,p-Coumaroyl-CoA and sinapoyl-CoA also act as substrates. The enzyme is widely distributed in roots of higher plants.,384,1.0,-0.06747101,-0.07430447,-0.091214485,-0.03635136,0.09754627,0.10193245,-0.113955684,0.013255868,0.08529893,0.021195574,0.10374761,-0.03907798,-0.07462195,0.03731141,-0.0006027985,-0.027931307,-0.10125901,0.009682257,0.027547056,-0.0750081,0.041579857,0.041957542,-0.026695,-0.01296141,-0.016784763,0.050380968,-0.020112064,-0.034299325,0.060388483,-0.0620242,-0.055542428,0.08650391,0.05823977,0.00014332817,-0.026127515,0.10431734,-0.057412595,-0.096141,0.056010682,0.014300282,0.09049684,-0.06043739,-0.0070380466,-0.05489903,-0.09612739,-0.05025006,0.0018418403,0.0047975644,0.046236333,-0.055974424,-0.016284931,-0.017545342,-0.07887401,-0.018635353,-0.067977145,0.04769393,0.08059806,0.0034615803,-0.011125491,0.03662067,0.043296747,0.04933869,-0.043703757,0.043723498,-0.007874378,0.0033788544,0.004411905,0.014522536,0.012261389,-0.0027147536,-0.06833041,-0.05890441,-0.041893125,0.010137503,-0.05124654,0.01642904,-0.065726236,-0.02261413,-0.010340435,-0.00936837,0.011503711,0.049751647,-0.016708901,0.028738225,0.035943355,-0.0035573856,-0.07213671,0.023020407,0.019912416,-0.023032477,0.041799683,-0.0021366414,-0.03451097,0.07375425,-0.090440385,0.08631178,0.055543017,-0.05732863,-0.031981733,-0.05588841,-0.05958531,0.051699225,-0.017917577,-0.060669955,-0.08202623,-0.0025755374,-0.08792237,-0.011474803,0.046882607,0.024163617,-0.076161854,0.043726183,-0.03060866,-0.026609015,0.0337548,0.080349594,-0.010995577,-0.017816832,-0.037387773,0.033567447,-0.011166837,-0.025455335,0.046559427,0.09687292,0.012965807,-0.010257095,-0.054017942,-9.179255e-34,0.09295978,0.014670144,0.0038350497,-0.010115984,-0.038051803,-0.054794405,-0.030753614,0.037013516,-0.0463011,-0.03372822,-0.023231013,-0.0145647125,0.014582993,0.03356165,0.0121203335,0.0020635147,-0.0377546,-0.00409847,0.042389788,0.05177122,0.016996158,-0.0068613784,-0.06057312,0.050316487,0.008252528,0.04028509,-0.01345448,0.03410021,0.036999352,-0.010429981,0.026570495,-0.053965908,0.017892577,0.011922426,0.06874119,0.0023574128,-0.10662942,-0.030578425,-0.08433582,0.07790215,0.04986901,-0.059791107,0.042906374,-0.023175132,0.05803724,-0.05367688,-0.121000126,0.058368713,-0.008131181,0.06761296,0.079398535,-0.007861294,0.09016602,0.03947564,-0.032058004,0.02545112,-0.026796466,-0.0010419592,-0.024288109,0.006710088,0.024551172,-0.024036549,-0.047558267,0.054983556,0.028117323,0.09689107,-0.04988316,-0.035361037,0.0143223405,0.13808104,-0.015023343,-0.00829172,-0.049957436,0.080163404,0.06364842,-0.025345711,-0.008302015,0.118404314,0.032405183,0.083769195,-0.026590148,-0.048408143,0.003243102,-0.06868035,-0.05790137,-0.022537254,0.019497024,-0.039663535,-0.005967257,-0.011830768,0.07938244,-0.0036434762,0.055472076,0.032256015,0.023798771,-1.1858994e-33,0.07229974,-0.06597993,5.921602e-05,-0.09432319,-0.129022,0.06410165,0.036598824,-0.08570793,-0.03339032,0.03175718,-0.008265628,0.069829114,-0.021056894,-0.022106778,0.01365643,0.003198214,0.059814192,0.057452377,-0.004271512,0.01560596,-0.041637644,0.07273649,0.08537388,-0.0360899,0.07224837,-0.029220315,0.025411747,-0.012491159,-0.043703888,0.045763124,0.019758012,-0.010487957,-0.020709064,-0.02026302,-0.063625805,0.023597203,-0.08190569,-0.02217326,-0.0021757288,0.015125049,-0.029489117,0.046734516,0.058441352,0.004632083,0.0032057448,-0.0091665955,-0.062282614,-0.032675877,-0.04480894,-0.0006732752,-0.029556375,0.08637515,-0.015365509,0.0010580857,-0.011204833,0.03198966,0.0030776332,0.010504289,-0.004201202,-0.089774996,-0.030638678,-0.012417554,-0.057483304,0.008367166,0.053577516,0.07180263,0.048318822,0.049334988,-0.007780089,0.036200806,0.03135665,0.02480543,0.073249176,0.06393403,-0.08535235,-0.022154847,-0.028739078,-0.0034243597,-0.08203134,-0.038134716,-0.029696397,-0.011070967,-0.055998947,-0.087681696,-0.13247181,-0.13268104,-0.004275536,0.035394996,0.119999215,0.03694341,-0.058053635,0.008829678,-0.007301258,0.005465876,0.14502208,-2.7669856e-08,-0.032609474,-0.006444379,0.004652587,-0.027456492,0.07688992,0.03678836,-0.014212681,-0.058840543,0.04727515,0.030537762,-0.056167763,0.059109915,0.036799926,0.026103312,0.046727475,-0.0016220079,-0.008668614,0.027077122,0.011703047,-0.0050638355,-0.046691254,0.0066657336,-0.050651927,0.054047517,-0.0046997583,-0.06324942,0.057681896,0.05695606,-0.0009763201,0.044486176,0.023670087,0.04316786,0.0046396577,-0.0063836356,-0.017463898,0.055066723,0.060258046,-0.06710243,-0.070482835,0.09661668,-0.016643679,-0.045847543,-0.035669997,-0.022176525,0.025762958,0.023517897,-0.014952479,0.026816977,0.08849005,0.039806776,-0.002706459,0.0237093,-0.026989643,-0.0980204,-0.08073222,0.016135506,0.039411593,-0.042904712,0.00925685,-0.053393014,-0.04424815,-0.026842926,0.19339675,0.005129439 +2.4.1.247,"The enzyme from Clostridium phytofermentans is also active towards towards beta-D-galactosyl derivatives of L-mannose, L-lyxose, D-glucose, 2-deoxy-D-glucose, and D-galactose in this order. Differs from 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase (EC 2.4.1.211) in being active towards L-rhamnose and inactive towards N-acetyl hexosamine derivatives.",384,1.0,0.047997944,-0.11402013,-0.05433353,-0.008571188,0.08261405,0.03285544,-0.0158318,-0.0013181237,0.020251608,0.08682167,-0.018781539,0.05857602,-0.012596689,0.09460986,-0.002669011,0.02102862,-0.017106285,-0.012634399,0.0757613,0.07123874,0.107711464,0.0051092748,0.038026888,0.04433742,0.08797905,-0.024873408,0.08132294,-0.08685671,-0.08122423,-0.075838834,0.0048451186,-0.1028273,0.061037492,-0.035949834,0.017621024,0.03331314,-0.025980087,-0.041813303,0.040670037,0.031270914,-0.01832708,-0.03490255,0.013714578,-0.039868932,-0.10499789,-0.020651806,-0.13036141,0.06028798,0.05097797,-0.008555199,-0.0013230529,-0.08191389,-0.021363907,0.012081099,0.030426677,0.07470623,-0.08265792,-0.0074448218,0.050751533,-0.011613522,0.023995273,0.0332543,0.06466623,0.053357724,-0.019434143,-0.10249839,-0.000105780266,-0.060727615,-0.024592862,0.009342376,-0.022114424,-0.057146426,-0.00475039,-0.08338482,0.10888418,0.004311295,0.020983504,-0.047930934,-0.0037038366,-0.08198445,0.02027597,-0.009186134,0.035292618,0.041430354,-0.03223892,-0.00655518,0.018360369,0.010435649,0.110751875,-0.00019090799,0.037535194,-0.03912733,-0.017775273,-0.024236823,-0.013193801,-0.02495703,0.06366039,0.020728482,-0.017278716,-0.02721283,-0.005476748,-0.010015016,-0.0021297943,-0.06525145,-0.051675215,0.04793042,0.020678695,0.046788815,0.00902178,-0.060577214,0.016054088,0.016879834,0.08292651,0.019010251,-0.11267038,-0.010720537,0.009341702,-0.11030226,-0.014854599,-0.056580547,0.050525684,-0.060865216,0.048082102,-0.012423144,0.0039412063,0.1393493,-0.050076187,2.5376403e-33,0.035949063,0.03859138,0.00268493,-0.038020857,0.04555988,0.019618921,-0.06172043,-0.0069750296,0.013892663,-0.027459212,-0.10594547,-0.012833827,0.0379696,0.03420153,-0.022291046,0.07382175,0.0076808366,0.04886899,0.049546547,0.03981219,-0.016552683,0.027691133,-0.046937518,0.046576105,0.06017488,0.030488167,0.01642499,0.06834531,0.012411173,-0.002829343,0.053475175,-0.04365578,-0.024565266,0.014287948,0.00866247,0.06774154,-0.06095312,-0.054540724,0.0030237555,-0.05846821,0.064832166,0.042959083,-0.025739558,-0.0146680465,-0.049551204,0.0062722024,-0.024495829,0.07442606,-0.027312677,0.10030819,0.033265054,-0.0025857517,0.008820758,-0.010144227,0.0020837395,0.06049709,-0.09053244,-0.010270429,0.13098642,0.030775629,0.008508614,0.031170184,-0.013307552,-0.031947676,0.03467524,0.0036541843,-0.012760413,-0.057423003,-0.040221892,0.010183271,-0.04610011,-0.07114504,0.03327104,-0.00032746227,0.062049598,-0.078298,-0.052465077,-0.037480216,0.059655268,0.013985719,0.049953777,0.010331013,-0.0033501722,-0.0146584315,0.0121476585,-0.026933787,-0.09570364,-0.06601211,-0.011856668,0.054929234,-0.060979385,-0.08325283,-0.04931703,0.049901493,0.006038855,-4.1351768e-33,0.06380147,-0.08612969,0.07622272,-0.00788719,-0.015881328,0.05693445,0.030177806,-0.06463207,0.05432671,-0.08677996,0.06830884,0.050481856,-0.07379731,-0.041332964,0.04868931,0.018710334,0.023204098,0.06396107,-0.09308962,0.026189974,-0.04256949,0.09597855,-0.0296954,0.034456115,0.066351525,-0.050940704,0.010051882,0.114293516,0.032518502,0.042524077,0.030785346,0.032320417,-0.034284182,-0.03667536,-0.028802995,0.017590541,-0.047740035,0.011495019,-0.007619301,0.051392354,-0.009902333,0.047263928,0.0043032253,0.0038651074,0.073882245,0.070925,-0.09160119,0.014444646,0.014240943,-0.0132093355,-0.06379779,-0.055141754,-0.0103919,-0.0053465245,0.018341277,0.061095733,-0.05191675,0.06746767,-0.00071580213,-0.08695896,-0.05779138,-0.033295646,0.050597988,-0.011007505,-0.01358142,0.015835874,-0.054060455,0.03172841,0.048423868,-0.053742435,-0.030611655,-0.027281493,0.01916782,0.0761028,-0.049209602,-0.045239978,-0.123791344,-0.073507816,0.010217282,-0.006151414,0.058991745,0.035069875,0.028681356,-0.062410165,-0.0044823717,-0.0017466629,0.021164272,0.08754723,-0.00523405,0.010390374,-0.026654003,-0.06827084,0.0076256366,0.027335528,0.11275031,-4.581774e-08,0.045598842,-0.011083202,0.079351716,-0.062249348,0.007567278,-0.014122768,0.007562941,0.0070092585,0.012114589,-0.0515526,-0.008091512,0.1348389,0.032846767,0.031497177,0.007927377,0.026025757,-0.036788046,0.033885535,-0.048530165,0.06207906,-0.086841725,0.0052144625,-0.078462265,0.055222683,0.043078724,-0.051099446,0.051785853,-0.008666444,-0.021285057,-0.010934163,0.046047788,0.0551551,0.007450769,-0.030709807,-0.05853787,-0.014037684,-0.05327505,0.014299303,0.068728946,0.040818837,0.013772815,-0.027668446,-0.0019897162,0.0033331988,-0.11743389,-0.017741518,-0.05294105,0.0015541615,-0.06652407,-0.031399515,0.010553987,-0.03910579,-0.13333805,-0.0977425,0.0073274486,-0.055683907,-0.023161003,-0.053172197,-0.024558036,-0.0940432,0.03741136,-0.018449282,0.16926838,-0.053709723 +2.4.1.248,"Specific for (1->6)-alpha-D-glucans (dextrans) and, unlike cyclomaltodextrin glucanotransferase (EC 2.4.1.19), without activity towards (1->4)-alpha-D-glucans, such as amylose. It also has no activity on oligosaccharides, such as amylopectin and pullulan, containing (1->6)-alpha-D-glucosidic linkages at branch points. The enzyme from Bacillus circulans T-3040 has been shown to form cycloisomalto-oligosaccharides of three sizes (7, 8 and 9 glucose units). It will also catalyse the disproportionation of two isomalto-oligosaccharides molecules to yield a series of isomalto-oligosachharides and the addition of D-glucose to cycloisomalto-oligosaccharides with ring opening to form isomalto-oligosaccharides.",384,0.99999994,-0.08440515,-0.07838426,-0.07021129,-0.005657722,-0.062374897,-0.0049671736,-0.03540891,0.030995648,0.13312857,-0.020044304,0.02268899,0.03703711,0.025576353,0.014581815,-0.07692125,-0.015946565,-0.04912701,0.05682764,-0.041889884,0.0020662115,0.034656096,0.008841498,0.0049820463,0.05713882,0.04559222,-0.082247086,0.012980355,-0.07745166,-0.07153922,-0.009571156,-0.008918576,-0.09444107,0.024067247,0.0008341021,0.068447135,0.03699832,-0.03463737,0.022498097,0.034853578,-0.03850837,0.013592656,-0.030422945,0.038270626,0.011879336,-0.11204211,-0.07980691,-0.04668175,0.025505805,0.029842598,0.00410096,-0.023419926,-0.068581544,-0.051317394,0.054081354,0.10480736,-0.0011195339,-0.104479015,-0.03998838,0.057922833,0.05411467,0.024467792,0.028924845,-0.015802283,0.034052588,-0.091841176,-0.04683973,0.031224601,-0.04688396,-0.0804956,0.021456212,-0.07727444,0.034140542,0.015596963,-0.0100634275,0.044629816,0.042714205,-0.014352503,-0.005085992,-0.03768314,-0.0016450858,0.07067167,0.041016333,0.10291409,0.092361756,-0.0046135634,-0.035457715,0.053997114,0.07591439,0.025470773,0.08010557,0.057448275,0.06304792,0.00236185,-0.034176826,0.02011894,-0.031230768,-0.009279127,0.031760085,0.10499508,-0.026477735,0.0062775016,0.04087617,0.09299187,-0.05415648,-0.051156946,0.038838457,0.0029449884,0.070153385,0.1034396,0.01840111,0.0034241728,-0.011422904,0.0028854043,-0.043209378,-0.11418764,0.05375226,0.02238289,-0.065006234,-0.00057617,0.020807734,0.016568944,-0.014846372,0.063711025,0.0055689444,-0.014083415,0.12117669,-0.019123696,4.4514487e-33,0.039013147,0.0124474,0.018162787,0.06735493,-0.0068117534,-0.006835841,-0.052226618,-0.012847674,-0.03659782,-0.01363387,-0.11690154,-0.03809164,-0.027316598,0.13137141,0.046211842,0.06632172,0.02387551,-0.092962615,0.03652934,0.021538744,0.05474629,0.04047209,-0.02929893,0.010989734,0.03191819,0.05385996,-0.07292066,0.08197048,-0.000691835,-0.022164848,0.02826821,-0.07052934,-0.071452335,0.015754206,0.0643749,0.093499005,-0.04381873,0.0029245573,0.0099362,0.034053303,0.005509135,0.0033419242,-0.02251691,-0.06367598,0.07206021,0.00895466,0.011671603,-0.018129451,-0.036143247,0.09675228,0.09819868,0.02720291,0.005971807,-0.007039084,-0.007258818,0.029605825,0.005581519,0.0044056326,0.03245919,0.034359474,0.010365543,0.030300766,0.029796,-0.046528235,-0.0044360277,0.034681987,-0.05466255,-0.0065829083,-0.10932862,-0.009148717,-0.03557058,-0.042175587,0.02091382,-0.028921148,0.050205752,-0.011643728,-0.01850694,-0.018587377,0.055347607,-0.03961006,0.03335146,0.0034491038,0.02644477,-0.031720262,-0.038628303,-0.005672541,-0.06462711,0.020364827,-0.064013064,0.06570019,-0.053092077,-0.07436078,-0.13007517,0.10950898,-0.035622187,-5.9806846e-33,0.08800894,-0.09302284,0.093631096,-0.071572565,-0.094400294,0.046765096,0.025441956,-0.0076793768,0.031169718,-0.060482807,0.06527019,0.019880217,-0.023924008,0.018340982,-0.0072051533,-0.029356003,-0.08364452,0.09641235,-0.046533737,0.026779179,-0.07551792,0.102116466,0.0038234019,-0.044377036,0.046849262,0.0012952114,0.07276697,0.07721385,0.0324245,-0.008921148,0.011191593,-0.054944783,0.004835328,-0.024866508,-0.10679394,0.05873825,-0.030404234,-0.082715265,0.017522918,-0.008456415,0.0063353097,0.01239642,-0.004722451,-0.025377726,0.029245269,0.09253359,-0.008566263,-0.024878219,-0.0063434634,0.01837704,0.01918533,0.04403616,-0.026030896,0.06750208,0.02549633,0.066460535,0.03739116,0.029482475,-0.011931064,-0.10274461,-0.056618758,-0.0029943718,0.060536463,-0.01417775,0.08443089,0.036879063,0.011158095,0.06320051,-0.007025676,-0.016307015,-0.019123232,-0.029166354,-0.0438888,-0.03954018,0.03102176,0.002549069,-0.10918318,-0.058069468,-0.007931123,0.012867257,-0.020530224,-0.02680966,0.037511285,-0.03803398,0.05253463,-0.03059637,0.08880794,0.03766321,0.012446142,-0.0006641955,0.020516101,0.016793057,0.08358716,0.033685613,0.04222562,-4.8099423e-08,0.02584957,-0.025538329,-0.084855005,-0.08647094,0.011093675,-0.042156085,-0.02777837,-0.007229016,-0.07295275,-0.002683971,-0.015533732,0.095381506,-0.04957319,0.03700231,-0.026987225,-0.03737838,-0.04054534,-0.05219571,0.026660915,-0.0049111443,-0.12738365,0.019960081,-0.074627414,0.020487502,-0.0021865957,-0.13940161,0.060084164,0.045409784,-0.0327091,-0.0065267733,-0.025342992,0.03497798,-0.05581221,-0.08795231,-0.05439313,0.0040643546,-0.07834492,-0.028840516,0.05970203,0.005649004,0.062110715,-0.07253828,-0.034204334,-0.027250418,-0.064810194,-0.008257329,-0.033398747,0.051323704,-0.018097818,0.079359524,-0.0051285336,-0.020665672,-0.08803847,-0.046238787,0.0103973355,-0.065090895,0.026034046,-0.003117403,0.010480439,-0.04943771,-0.010866452,-0.062147506,0.10667343,-0.039906275 +2.4.1.249,"Ternatins are a group of polyacetylated delphinidin glucosides that confer +blue color to the petals of Clitoria ternatea (butterfly pea). +This enzyme catalyses two reactions in the biosynthesis of ternatin C5: the conversion of delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside to delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside, followed by the conversion of the later to ternatin C5, by transferring two glucosyl groups in a stepwise manner [1].",384,0.99999994,-0.05792547,-0.027453063,-0.032403808,-0.020291653,-0.040098604,0.049043365,0.0057931044,-0.05353031,0.10209972,-0.0053226426,-0.026373684,-0.04618408,-0.09611472,-0.1116609,-0.06809048,0.030641684,-0.017510466,0.0302679,-0.054221317,-0.06336472,0.0069762575,0.01830556,0.026080944,0.027486283,0.011014509,0.010416523,-0.019221835,-0.020957347,-0.010731411,-0.09166192,-0.054318402,0.01443655,-0.06553338,0.017198263,-0.036125477,0.06944606,-0.15101254,0.0018305031,0.026001431,-0.041280948,0.053115815,-0.056999337,-0.07673069,0.031773794,-0.0066396,-0.069649935,-0.080092646,0.065330006,0.026036652,-0.0030246289,-0.014692865,-0.06302914,-0.048256777,0.07393609,0.02703537,0.006771696,0.034924906,-0.030525837,-0.006292265,0.04706076,0.010071486,0.036482003,-0.011179232,0.019331979,2.6953589e-05,-0.020753525,0.0048228507,0.017351406,-0.01656979,-0.09140573,-0.02365283,0.011612238,0.03754871,0.04352752,-0.009099192,0.08409149,0.063491836,0.060768105,-0.063120686,-0.017022915,0.06166994,0.038306348,0.0033698091,0.14682496,0.035122823,-0.022884287,-0.06616558,0.023904035,0.010437695,0.051423028,0.105872706,0.017330296,-0.021287791,0.0024259086,0.038009077,0.04721333,0.008468477,-0.07907448,0.08147624,-0.02219378,-0.06059673,0.00038441407,-0.031148236,-0.088965386,-0.09806054,-0.005104914,0.02918163,0.037760083,0.114726156,-0.05378119,-0.061168928,-0.05813367,0.0035541935,0.012350141,-0.085991785,-0.034951303,-0.018326752,-0.017252108,0.11138192,-0.08099281,0.015431659,0.038947016,0.014750924,0.057860862,-0.07418806,0.0056480267,-0.13381766,3.003841e-33,0.11403014,0.037275594,-0.028053844,0.039384533,-0.018324545,0.006271948,-0.050895788,-0.023289086,-0.09086864,0.025051443,-0.08581897,-0.11760088,-0.03185294,0.014658047,0.0463553,-0.030062621,0.013392822,-0.029015599,0.043046404,-0.029487502,-0.02210348,0.13745749,-0.10050843,0.00832688,0.03299973,0.107023925,-0.0013904285,0.071417235,-0.0252143,-0.03887109,0.0316263,0.0041543683,-0.01530611,0.07426332,0.09000467,0.025000226,-0.009294366,0.028786872,-0.010053639,0.1090175,-0.0023191127,-0.03211177,-0.00087458483,-0.023087252,0.10382284,-0.04548446,-0.073831365,0.021608999,0.022917975,0.0415736,0.013351362,0.031221544,0.106165946,-0.00014185965,-0.0698166,0.037631802,0.036919724,0.018646058,0.06321159,0.037577476,-0.04480245,0.07017511,-0.011592614,-0.08899783,-0.011766994,0.028140582,-0.15075095,-0.0018575985,-0.022887927,0.019521054,0.004930302,0.089433976,0.030074552,-0.020902894,0.12134965,0.057373222,-0.049314365,0.008586396,0.01563242,-0.061034016,0.0022759116,0.020810619,0.0034596352,-0.00061050215,-0.027856467,0.017977318,-0.015027194,-0.0066305543,0.032177664,0.03011853,0.040435653,0.001061455,-0.01378542,-0.028376697,-0.008923311,-4.361364e-33,0.05086802,-0.058277518,0.003514425,-0.035378452,-0.009654246,-0.0037347267,-0.064131476,-0.025422923,-0.017385347,0.038715187,0.062630855,0.061003003,0.003826408,-0.023741573,-0.026519135,-0.024363805,0.04413138,0.08689553,-0.058446802,-0.076077364,-0.0421169,0.07134644,-0.0061103352,-0.009026933,0.0412963,-0.00925763,0.08482473,0.07901538,0.002395495,0.0044959486,0.0064854166,-0.065035656,-0.002157627,0.026762517,0.025246948,0.049017835,-0.033019602,-0.024555808,0.06020645,0.05390963,-0.04779484,-0.021027396,0.005835628,0.00045133696,0.056246422,0.06507639,-0.048618007,-0.023045257,0.00077383796,0.020474723,0.079765946,-0.027200159,0.03224342,-0.046479117,0.057888642,-0.04710324,0.071503334,-0.073408045,0.11270466,-0.030946791,0.02693876,-0.018778868,0.06774318,0.026300455,-0.0120017165,0.027871558,-0.052287363,0.030636746,0.048784357,-0.022715375,0.03792237,0.027376074,-0.0150821125,0.012867914,0.021988658,-0.062655374,-0.011249476,-0.02893615,-0.00031412562,0.004657722,-0.027324857,-0.025031699,-0.0011173136,-0.08842724,-0.05183289,-0.04613498,0.05770934,0.11742487,-0.034649145,-0.0018760901,-0.05936745,0.035951138,-0.0028646807,0.073543325,0.07800562,-4.3719986e-08,0.043342695,-0.03330979,-0.037814956,-0.020227805,0.027083766,-0.0048342985,0.0022650543,-0.031879034,0.03824684,-0.007656436,-0.058327787,0.0916962,-0.021365395,0.026497148,0.012783386,-0.047703825,0.016671559,-0.035927985,0.032901768,-0.034611758,-0.026503168,0.051466487,-0.11072825,0.021703806,0.020826597,-0.13673767,-0.04809046,-0.0022044291,0.026200593,-0.030322753,-0.033401534,0.091687664,0.0061554103,-0.04676817,-0.001780068,0.070245266,-0.07958601,-0.035119586,0.0644965,0.024347706,-0.034904517,0.0069574607,-0.017344069,-0.004836081,-0.07268121,-0.14552286,0.073076196,0.03680379,-0.039809074,-0.008740992,0.024555955,0.034603152,-0.056819636,-0.007918741,-0.016958188,-0.034379352,0.046093006,-0.0038435115,-0.00039986963,-0.03965556,-0.0429183,-0.05963118,0.1364553,-0.04527793 +2.4.2.41,"Involved in plant cell wall synthesis. The enzyme from Arabidopsis thaliana also transfers D-xylose from UDP-D-xylose onto oligogalacturonide acceptors. The enzyme did not show significant activity with UDP-glucose, UDP-galactose, or UDP-N-acetyl-D-glucosamine as sugar donors.",384,0.99999994,-0.05741089,-0.07082454,-0.045525152,-0.023449117,0.026579117,0.015228701,-0.01016042,0.016138498,0.04672801,0.04784344,0.05470674,0.040599544,-0.10557803,-0.022610202,0.011646219,0.026785769,0.0050210864,0.013963457,-0.049334798,-0.008428822,0.11197493,0.028963573,0.025089605,-0.07047042,0.11537117,-0.074843004,-0.0060650576,-0.05175052,-0.0062260437,-0.09151309,-0.07049065,-0.041669797,0.017036038,0.0038260915,0.061453026,0.08281047,0.014481147,-0.07730413,0.02094364,-0.07073522,0.07121772,-0.058026575,-0.012874655,0.041554656,-0.13846275,-0.048788227,-0.04327083,0.025144024,-0.029419214,-0.050565165,0.02447534,-0.032344162,-0.017450394,-0.009391399,0.04438167,0.09889799,0.010144249,0.02857509,-0.014384864,0.019267341,0.054661136,0.09718106,0.03680366,-0.028761214,-0.015084379,-0.07224149,-0.037175428,-0.0018533284,-0.015854912,-0.021915134,0.027538134,-0.028748235,-0.008953598,-0.027191322,0.08452853,-0.0054720556,0.009646538,0.007903796,0.03436821,-0.047109947,0.020746319,0.0028440296,0.010667794,0.062544666,-0.026359575,0.0006149532,-0.01678971,0.094443716,-0.020928675,-0.015221313,0.0075745513,-0.0067655416,-0.04155733,-0.008651876,-0.06665036,-0.011168745,0.04670531,-0.050403938,0.025456116,-0.041581657,-0.01249481,0.032998208,0.003506654,-0.081816904,-0.054564208,0.018376464,-0.03825132,0.0017516013,-0.06359518,-0.0069467244,-0.005512428,-0.047446743,0.06708528,0.11272889,-0.08186414,0.0025632607,-0.030780097,-0.10355402,-0.047691666,-0.09415284,0.0041902787,-0.02259203,0.021021606,0.053473495,-0.055244226,0.061910164,-0.042353988,3.2694502e-33,0.034197006,0.027521215,-0.087786086,-0.064617716,0.003148326,-0.05329135,0.037659876,0.037257787,0.0022485084,0.06989788,-0.14718214,-0.09833482,0.029874189,0.119244084,-0.05950898,-0.0012698825,-0.0022441212,-0.04637736,0.059383675,0.06810795,-0.0028160554,0.044963125,-0.046217475,0.029730784,-0.019372141,0.018360497,-0.056264564,0.029906837,0.07319117,-0.033716917,0.007396685,-0.07936796,0.002566033,0.044321135,0.057833247,0.059526585,0.0004919076,-0.056299064,-0.011631393,-0.018385835,-0.016611185,0.039430648,0.013616464,-0.035796806,0.0262119,0.09284397,-0.093996406,-0.049545486,0.027291149,0.061768685,0.04404732,0.013661128,0.038622037,0.005139917,0.032433588,0.015824307,-0.05275245,0.028030368,0.0025285294,0.04689929,-0.054594986,0.003462151,-0.02712744,0.0225417,-0.015655497,0.09461122,-0.044898245,-0.072310895,-0.042866144,0.00075344974,-0.087058894,-0.081287496,0.0044113747,0.0074709286,0.015379683,-0.014068831,-0.04489115,0.042433005,0.007981557,-0.017516853,0.064798765,-0.0029429356,-0.045217443,-0.05162159,-0.027667483,0.023562817,-0.024856884,-0.025184508,0.01578038,0.07105132,0.007222665,-0.059970245,-0.030104784,0.038411364,0.049820397,-4.4903054e-33,0.053499714,-0.003141541,0.07206309,-0.03396213,-0.0053525753,0.07560504,0.006825617,-0.07571681,0.08093,-0.0119012715,0.035317585,0.06882314,-0.03464361,0.011307706,0.028044416,0.00455154,-0.010791964,0.056736045,-0.07767735,0.0035858045,-0.08905766,0.12020292,-0.00898909,0.019805718,0.07063728,0.017484872,0.002215901,0.05719078,0.026838021,-0.054610584,0.073738165,-0.023502737,-0.044304885,-0.028117284,-0.022417435,0.03922247,-0.0038144002,0.0044349907,-0.051115155,0.025423072,-0.008581158,0.03952854,0.019497149,0.06421563,0.027541986,0.033625655,-0.113417916,-0.023171674,-0.06651123,0.015400768,0.00504854,0.0823679,0.017588014,-0.009981106,0.026578944,0.09823008,0.14494695,0.016148005,0.015263239,-0.015179675,-0.04049598,-0.088051535,0.08196299,-0.04417306,0.047802072,0.0024898015,0.04443213,0.048944976,-0.0066915406,0.049103975,0.037473544,0.04713567,-0.035004493,0.0743463,-0.035026208,-0.003878276,-0.119360775,-0.027509475,-0.023272645,0.0031943792,0.023054473,0.040121343,-0.003226371,-0.027639857,0.04905863,-0.03423784,0.020846594,0.1046495,0.030842606,0.015481036,-0.0043469686,-0.08519707,-0.020755043,0.003624621,0.14942297,-3.8224528e-08,-0.012613629,0.037572276,0.014363934,-0.08621919,-0.053312957,-0.05405644,0.03737832,0.037859824,0.046515707,0.00019607708,-0.060683202,0.16188253,-0.017659234,0.018009834,-0.04613192,-0.028052088,0.028795961,0.03558392,-0.013664332,0.011084398,-0.06445543,-0.012806355,-0.18190768,0.03744452,0.004104731,-0.09579129,0.018531995,0.04052507,0.0523222,0.030987335,0.039607998,0.052434117,0.03913591,-0.034725256,-0.025884895,0.040866632,0.027710697,-0.06700915,0.029154222,0.000630345,0.005592098,-0.0482617,-0.0076982714,-0.016360829,-0.025364328,0.010486797,0.019280046,-0.034538757,-0.04331211,0.05877509,0.009057299,-0.033578847,-0.044414014,-0.14294147,-0.050332222,-0.036425613,-0.04091241,0.014215566,0.030058326,-0.036814924,-0.039844234,0.0026833902,0.15722711,-0.08823554 +2.5.1.73,"In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 (cysteine---tRNA ligase) for the direct Cys-tRNACys formation, Cys-tRNACys is produced by an indirect pathway, in which EC 6.1.1.27 (O-phosphoseryl-tRNA ligase) ligates O-phosphoserine to tRNACys, and EC 2.5.1.73 converts the produced O-phospho-L-seryl-tRNACys to Cys-tRNACys. The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism [1]. Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 (cysteine---tRNA ligase) and the indirect pathway with EC 6.1.1.27 (O-phosphoseryl-tRNA ligase) and EC 2.5.1.73 [2].",384,1.0,-0.051068075,-0.04298414,-0.06911353,-0.040701825,0.017907413,-0.01708512,-0.07650306,-0.01152129,0.053926893,0.03002618,0.042648587,-0.073600486,0.0037998816,-0.015949871,-0.06907781,0.0155586535,-0.1130826,0.03593945,-0.011921079,0.0102726,0.08348124,0.043722536,-0.052183524,0.031460304,-0.02413545,-0.14085673,0.0070315655,0.014321048,-0.015858307,-0.05819948,-0.051627986,-0.026788028,-0.025875494,-0.057558402,0.008753602,0.09918279,-0.03701964,-0.023918819,0.0707451,0.034610935,0.011978305,-0.009707179,-0.0052916715,0.0008479353,-0.08143439,-0.013156695,0.029385185,0.027432276,-0.015860943,-0.061535995,-0.08151211,0.0027324802,-0.010913881,0.10774245,0.022597695,0.09714512,-0.10655862,0.0032892842,0.004665433,-0.007862575,-0.03382675,0.070808485,-0.018701289,-0.047515042,0.008307724,-0.063531354,-0.0017463585,0.025808806,0.07944581,-0.0048667747,0.0025208804,-0.044688787,-0.009897997,0.0011892874,-0.02670519,0.14867876,-0.03386582,-0.028500522,-0.042725313,-0.03703003,-0.007899729,-0.008281722,0.0441587,0.02069358,0.10675008,-0.05478524,-0.033951893,0.067738526,-0.042812675,0.105055876,0.11883542,-0.02432331,0.03321011,-0.060098197,-0.027034864,-0.015544608,0.0828122,0.07264145,0.07648444,-0.044802733,-0.026831612,0.043916263,0.011486177,-0.05870385,-0.045897238,-0.025465356,0.034401774,0.049291767,0.032753948,0.024352983,-0.04571762,-0.05763716,0.04944368,0.010758609,-0.014979837,0.083008386,-0.010026728,-0.06599105,0.08162314,0.036391113,-0.029342685,0.0101705445,0.04040886,0.07743341,-0.010478617,0.03534241,-0.10725631,1.7546217e-33,-0.008900378,0.07010643,0.012702516,0.012921559,0.05378502,-0.03781883,-0.05994633,-0.02297966,-0.038913354,-0.006328318,-0.11806536,-0.024377538,-0.008150914,-0.02874098,-0.010793205,-0.021870105,-0.052477762,-0.044500496,0.0012785005,-0.010784212,0.002135491,0.04747681,-0.028617926,-0.026797082,0.06599245,0.03659207,0.013604775,0.02550762,0.0039300052,0.027464282,-0.020737382,-0.1171835,-0.05110886,0.004393506,0.035797596,0.03034809,-0.05004018,-0.04808521,-0.10001757,0.014927917,0.03590997,-0.033261057,-0.020495703,-0.013839701,0.004570897,0.02076551,-0.08822739,0.043766282,0.024270052,0.023422727,0.0645943,-0.029057447,0.060506616,-0.010306156,-0.06894652,-0.08153648,-0.056500904,-0.06288871,0.06239176,0.09663314,0.0070246696,0.03606252,-0.0237737,0.05352263,-0.0009604723,0.032511093,-0.1268087,-0.03535376,-0.03942282,0.035475407,-0.091210164,-0.052299272,0.075517885,-0.033293933,0.042809695,0.025819458,-0.056061424,-0.030552616,-0.014319724,0.026655635,0.0147764655,-0.021846745,-0.02905539,0.05778756,0.04121981,0.014604187,0.01752904,0.058093425,-0.02328212,0.10015804,0.07289923,-0.08592628,-0.016350871,0.069654524,-0.018269023,-3.282858e-33,0.04000887,-0.023937227,0.098091215,-0.116756506,-0.046593167,0.11802259,-0.012696702,-0.066203214,0.09705707,-0.11026015,0.050950505,-0.0108837,0.01403791,0.020239312,0.0021826068,-0.09370292,0.025339,0.08402682,-0.034032457,-0.008772525,-0.0019810083,-0.0035620383,-0.06583712,0.032569062,0.037556898,-0.004008841,0.04303831,0.10268965,-0.07755139,0.124266624,-0.013082686,0.033587344,0.02176877,0.00906533,-0.05275383,0.026867304,-0.093565345,-0.02844526,0.075308554,0.025488669,-0.0013283871,-0.0019620513,-0.01654402,0.065962,0.032440826,0.06686722,-0.023803681,0.018016465,0.0053962683,0.028191406,0.09415923,-0.011591628,-0.027535718,-0.009711718,0.020419361,0.018507682,-0.0067773545,0.026121268,0.01799338,-0.06438504,-0.046168122,-0.021938981,-0.023837835,-0.02957983,0.09409132,-0.0014329527,-0.036532454,0.06996327,-0.006422313,0.0334883,0.0017276697,0.053451356,0.046792462,0.049388062,0.0334594,-0.0018268472,-0.11275589,-0.011089629,0.015011261,0.006357123,-0.07542521,-0.03100147,0.050328232,-0.05937893,0.011477858,-0.05333388,0.051906735,0.031016896,0.024083143,-0.0068827868,-5.600568e-06,-0.006526131,-0.005762207,0.031763624,0.026362196,-4.7092026e-08,0.068994604,-0.049093623,-0.076894745,-0.029732784,-0.025125569,0.022740815,0.01922618,0.08249015,0.015464936,0.015316224,0.040206697,0.052828494,0.032661907,0.033654016,0.04278727,0.0012010069,-0.017724257,0.062649794,0.008938841,-0.024309348,-0.06485558,0.008505123,-0.07492545,0.07848874,0.05388364,-0.08331262,0.025791781,0.042733308,-0.052566726,-0.056278657,0.07478878,-0.015321958,-0.049325384,0.032156203,-0.1091906,0.059020873,-0.0634916,-0.040118974,-0.05216228,0.030142317,0.032274712,0.0030560922,-0.08747097,0.005431134,0.011655327,-0.03555514,0.015267343,0.08579748,-0.032724094,0.011316699,0.03203129,0.017635722,0.05593268,-0.048168603,-0.023948837,-0.07667073,0.020061921,-0.014595051,-0.05121538,-0.03690989,0.032573353,0.04577606,0.17609394,-0.06149121 +2.5.1.74,"This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein [1], with the C-terminus located in the periplasm [3]. It is highly specific for DHNA but not for a specific length of the prenyl chain [2].",384,1.0,-0.059635848,-0.022037828,-0.08312415,-0.03672202,-0.09474895,0.0419492,-0.059989024,-0.021893164,0.0353565,-0.008066215,0.011772577,-0.035122793,-0.07951623,0.0481782,-0.02843236,0.041082166,-0.06964795,-0.028992988,0.08464479,-0.015623796,0.0919126,0.026645854,-0.0769263,-0.118547596,0.017678315,0.03245431,0.07378429,-0.0010073138,-0.013237694,-0.046858158,-0.010411869,-0.06320497,0.03888832,-0.029908838,0.01950977,0.09989393,-0.050362937,-0.033100713,0.074716434,0.06220987,0.07755759,-0.0066907164,0.016449437,0.023502994,0.0045295386,0.05403488,-0.0034268617,0.05384659,0.061210632,-0.020741746,-0.046349276,-0.05956497,0.018417098,0.040023167,0.1019224,-0.041498978,-0.015378766,0.035580326,0.027668918,0.0019636417,0.009309246,0.029228257,0.037869576,-0.010795009,0.06554035,-0.1031272,0.0017533295,-0.049601942,0.010786348,-0.027447151,-0.0032209705,-0.020432156,-0.003922889,0.008871287,-0.041382045,-0.013896853,-0.015758216,-0.04225253,0.015273456,-0.024984675,0.04075787,0.028666722,-0.024732972,0.15425119,-0.0050373496,0.05504668,-0.0003899628,-0.025444917,0.034230012,0.029607933,-0.0129028885,-0.027652271,-0.06394312,-0.041963648,-0.11450321,0.015119074,-0.00058859977,0.08281821,-0.041336354,-0.012582816,0.048657212,0.0060977973,-0.054462384,-0.13027044,-0.072798796,0.0014874415,0.044608466,0.09381735,0.016264195,0.053390104,-0.034134705,0.067968875,-0.002391168,-0.013196303,-0.042468645,-0.00035657996,0.033237718,0.0066175694,-0.039605968,-0.00982968,-0.07869587,0.011758603,0.060293034,0.071855105,-0.040896427,0.013777995,-0.1136644,-3.0798216e-34,0.027950723,0.0050031566,0.019641839,-0.045493275,-0.022562874,-0.07761808,-0.03281245,-0.022833344,-0.050351854,-0.07403316,-0.031807654,-0.06380387,-0.036671065,-0.010315486,-0.042937655,-0.061913367,0.010948666,-0.046490863,0.08220756,-0.003174343,-0.021473031,0.028230824,0.015650952,-0.06373134,0.060413394,0.009622169,0.058158237,-0.036112316,0.016735261,-0.012898144,-0.02856382,-0.080081455,-0.053752977,-0.03138613,0.037921168,-0.04181231,-0.034424454,-0.018100804,-0.030174978,-0.013018729,-0.0026791587,0.004074069,-0.0344687,-0.053730674,0.058907297,0.006959107,-0.06842988,0.15784384,0.0106430845,0.00054252986,0.035922717,-0.018257383,0.089745335,-0.037194762,-0.11253828,-0.003713839,0.0060820775,-0.028087704,0.05566322,0.086357795,0.008904929,0.037161365,-0.062644,0.004876627,0.0040021385,-0.033894595,-0.020490898,-0.046885062,0.049646243,0.053250916,-0.035095252,-0.03709691,0.068694964,0.062004898,0.0012342859,-0.01355411,-0.09953456,0.041638695,0.1084384,-0.031426996,0.05914455,-0.035209753,0.037088245,-0.027998932,-0.010063851,-0.019688709,0.033723123,-0.036724802,-0.07998531,0.07298258,0.06957187,-0.096349366,-0.0362442,0.03925423,0.038271308,-2.5723038e-33,0.083640814,-0.11378024,-0.00065593317,-0.12271986,-0.05531503,0.024180384,0.048937548,-0.00010187161,-0.034483355,0.031235395,0.08120442,-0.023741497,0.057021685,-0.0036022214,-0.01262236,-0.020166976,-0.026652316,0.017861173,-0.011541303,-0.058940355,0.05639906,0.07373261,-5.492755e-05,0.07927196,-0.028669015,-0.01258658,0.04127873,0.11869599,-0.033068098,0.12498086,0.014743914,-0.005490827,-0.058026884,-0.032727435,-0.02121676,0.035590947,-0.062021345,0.043038573,0.067426145,0.032095335,0.030552471,0.04476415,-0.028485272,0.0012526456,0.027336778,0.091942474,-0.039417144,0.055835165,-0.024972208,-0.07313409,-0.0035680535,0.012881116,-0.009055016,-0.031776264,0.031825192,0.052010328,0.015720034,-0.053064108,0.07646397,-0.047298275,-0.121315405,-0.09157577,0.05789473,-0.0049280054,0.0053761965,0.06266336,0.024349082,-0.00030716468,0.05056125,-0.053085208,0.039704077,0.0034491157,0.024219682,-0.0024813914,-0.084332496,-0.05042606,0.009682202,-0.01851538,0.036567032,-0.017389452,-0.0036267638,0.0007155735,-0.047565304,-0.013944659,0.03192239,-0.07738705,0.14933637,0.08812967,-0.0738382,0.085757054,0.0009519697,0.0703267,-0.09859508,0.0367241,0.033188496,-3.867788e-08,-0.005926368,-0.04093758,0.09171683,-0.0006323903,0.018118693,0.010073845,-0.018603276,0.012319071,0.10370303,-0.003998027,0.0031862722,0.0799513,-0.0059143486,0.0057409615,0.011845587,0.025768196,-0.014316878,0.00949872,0.0007637926,-0.086843185,-0.010347032,-0.015379835,-0.13272734,0.022779098,0.016566698,-0.051107112,0.0140234595,0.0014239036,-0.017705532,-0.017541299,-0.0043626567,0.06166842,-0.012669911,-0.04764837,-0.03148555,0.047855463,-0.023721348,-0.019364754,0.053412657,-0.020686172,-0.028002646,-0.024195295,-0.0033333227,0.011367507,-0.010640654,0.0065873903,-0.015320305,0.061599974,-0.043161437,0.024345247,0.077558435,-0.0062880935,0.0654047,-0.0773759,-0.09496867,0.011539675,-0.07805933,-0.044497617,-0.06272498,-0.02945392,0.03249373,0.011703125,0.17134069,0.010333985 +2.5.1.75,"Formerly known as tRNA isopentenyltransferase, but it is now known that prenyl diphosphate, rather than isopentenyl diphosphate, is the substrate.",384,1.0,-0.05237077,-0.06120595,-0.050859366,-0.017088357,-0.072869256,-0.046574708,0.01656633,0.050050344,0.007699302,-0.017544167,0.11870834,-0.019831754,-0.104942925,0.04449622,-0.052666765,-0.020621823,-0.0029444685,-0.043801375,0.10234776,0.0023860617,0.0340755,0.10605817,-0.06966537,-0.02121816,0.06551867,-0.020000797,0.012042537,-0.039205138,0.09903062,-0.03654943,-0.09210568,0.037007824,0.03734415,-0.06035348,-0.0045308885,0.105251014,-0.105429776,-0.018205447,0.081869125,-0.012674214,0.069801666,-0.043222148,0.02625517,0.013722958,-0.07870586,-0.008737491,0.063557774,0.021075537,-0.027974214,-0.021487974,0.02426515,-0.043010235,-0.026837097,-0.0007640028,0.029946333,-0.03975299,0.0038680101,0.014501235,-0.041948628,0.04266843,-0.012290588,0.007242614,-0.06130385,-0.084825665,0.06979304,0.002164279,0.046032593,-0.011642663,0.09990918,-0.05227315,-0.08332718,-0.015121999,-0.018423269,0.06702096,-0.05695886,0.052552335,0.015305697,0.024762757,-0.013700609,-0.000105258005,0.04304524,0.03547547,-0.01187849,-0.0015077025,0.022602353,0.0098641245,-0.08413412,0.02033957,0.012946007,0.0018293264,-0.0036031648,0.079894386,-0.011056387,-0.009136424,-0.104980804,0.066286154,0.0062075327,0.07033083,-0.003659958,-0.003551025,0.07005331,0.06134167,-0.1156304,-0.013413345,-0.04485531,-0.050168596,-0.012698969,-0.016611572,-0.013403419,-0.0009746193,-0.031307235,0.031354405,0.030792942,-0.017038403,-0.0669155,-0.013184275,0.027141778,-0.024274064,0.075263634,0.019489868,-0.06837814,0.063615814,0.0293487,0.07549418,0.0062886546,0.01569242,-0.023789054,2.3935774e-33,0.038119152,0.051318213,0.043410346,0.013780949,-0.05618531,-0.021774743,-0.061767165,-0.03154537,-0.0603956,-0.05223811,-0.03772194,-0.09984877,-0.055255916,0.018707814,0.0033683842,-0.02267393,-0.06626933,0.031709008,0.12019805,-0.026020538,-0.055416614,0.05713851,-0.035403058,-0.043497976,0.030028062,0.00658588,-0.056339692,-0.0028674945,0.007513244,-0.017695352,0.03525527,-0.06005116,0.009309117,-0.06692416,0.04997479,-0.09345628,0.0020252035,-0.040622517,-0.15754816,0.025366144,0.031320095,0.005879998,0.005298332,-0.0069890404,0.06382465,-0.05593308,-0.049830794,0.011829502,-0.00478274,-0.029472727,0.028561153,-0.040307548,0.087325886,-0.053645518,-0.041686866,0.017466892,0.027518017,-0.019624677,0.052827258,0.08116401,-0.0007936954,0.06389712,-0.07451604,0.05888563,-0.016930858,0.010544706,-0.078015715,-0.037398744,-0.015211602,0.08489435,-0.02313681,-0.028600622,0.03753422,0.035059508,0.034550387,-0.0032218096,-0.08826479,0.0013730484,0.00915972,-0.011160438,-0.009672135,-0.06950622,0.005523577,-0.09917543,-0.08358084,0.015166376,0.061765444,-0.06372592,0.025081404,0.04552317,-0.021460546,0.01362136,-0.096578605,-0.033234153,0.02056455,-4.6448017e-33,0.075194106,-0.07873027,-0.03750787,-0.09709655,-0.055130515,0.015213393,0.059907366,-0.051980216,-0.022916,0.0012829993,0.07777042,-0.009435575,-0.0020546704,-0.00949039,0.021719934,0.051446196,-0.024693709,-0.0013662472,0.019210393,-0.033606306,-0.02306963,0.04634216,0.025171012,0.13472022,-0.0016410336,-0.058420457,0.072049245,0.06654594,-0.03430952,0.113724515,-0.059973594,-0.024809022,0.090391584,0.025661508,-0.098870456,0.058311455,-0.03469652,-0.010038306,-0.010218513,-0.028669728,0.006361971,0.03292387,0.006811012,0.02037041,-0.07067982,0.025932673,-0.05781057,0.0034283875,-0.02741151,-0.0457507,0.09459075,0.05560063,0.031333175,-0.021216834,0.075437635,0.013592239,-0.10818912,-0.003925357,0.022338333,-0.008484367,-0.0045484374,-0.09662715,-0.03367256,-0.092176214,0.140325,0.05554782,-0.031045401,0.062033925,-0.02289364,0.016259903,0.055530895,0.06819299,-0.012164026,-0.018968035,-0.013656634,0.0051332153,-0.030944353,0.018829633,-0.03271148,-0.026869498,-0.024983212,-0.007433091,-0.01825188,-0.036539268,0.038759857,-0.037954256,-0.0032582455,0.089693084,0.025209213,0.10489332,-0.011300859,0.044438627,-0.037854325,0.03508669,0.043573886,-3.2320322e-08,0.03157446,-0.0030630415,0.018297898,-0.006851027,-0.024103623,0.04215769,0.035567243,-0.0034292366,0.027161755,0.030291947,-0.066915385,0.03143066,0.026140423,0.053046722,0.088818245,0.015155041,-0.06701589,0.029808152,-0.04309503,-0.0116355615,-0.0457645,0.028174866,-0.056576654,0.010514618,0.010205831,-0.0578484,0.036472138,0.096756145,0.027824476,-0.059408832,0.03686347,-0.00025659418,-0.008069957,-0.017691221,-0.023332031,0.115856506,0.031069268,-0.062365085,-0.050248567,0.07609051,-0.07918424,-0.05100732,-0.098129645,0.023527572,-0.017804323,0.041018933,-0.011673852,0.13664483,0.019348433,0.018694593,0.04795127,0.030597595,0.017673044,-0.014940798,-0.0021727048,-0.052828386,-0.03822416,0.0016100998,-0.052649576,-0.0017889973,0.069634125,0.022107663,0.20189454,0.01793262 +2.5.1.76,"A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).",384,0.99999994,-0.05690102,-0.07805622,-0.097512,-0.039350912,0.07015839,0.047426548,0.00040252754,0.043994363,0.039983958,0.01717267,0.01252059,0.022752644,-0.10311246,0.031628117,-0.060592197,0.08735832,-0.050902124,-0.030002497,0.05301311,-0.047796723,0.1231941,0.04944382,-0.015666695,-0.02215977,0.011105486,0.0534628,0.0035432035,0.044285763,-0.031581234,-0.06311472,-0.021706406,-0.0015153005,0.01993416,-0.035551224,0.048732013,0.09630843,-0.063574106,-0.024556834,0.006405207,-0.0058555254,0.08337011,-0.020144053,-0.028509917,0.0074129845,-0.049843725,-0.043124866,-0.0011786136,0.06849102,0.04260232,-0.068093784,-0.1107305,-0.05346521,-0.07738979,-0.022994677,0.0075623584,0.033966146,0.005075799,0.009008537,-0.009691026,-0.054013666,-0.007942038,0.032973014,0.0069516203,-0.0060753264,0.09550488,-0.040060278,0.07551818,-0.0814513,0.036677968,-0.03457712,-0.055715643,-0.012988581,0.025363201,0.03499887,-0.01592921,0.038585354,-0.084501,-0.023102544,0.017776905,-0.024723869,0.066667534,0.019517688,-0.023738638,0.039111674,0.05006274,-0.017103562,0.007490121,-0.020631596,0.072814964,-0.05319914,-0.01153557,-0.05225095,-0.036671553,-0.040616963,-0.047533605,0.014259302,0.03027822,0.03682761,-0.01301682,-0.0040154643,0.009453948,0.038583223,-0.05628457,-0.091693394,-0.06690344,0.018094508,-0.007994693,0.03657503,0.0065965843,0.04490669,-0.054185096,-0.031847343,0.027673611,-0.01248184,-0.028418431,0.06969551,0.01629656,-0.057465836,-0.05065372,-0.01550205,0.0003187611,-0.03187048,0.049706236,0.0911212,-0.016953127,0.030336384,-0.15300474,2.0659745e-33,0.09071379,0.12248696,0.088744,-0.0107558705,0.029972779,-0.06425426,-0.068919465,0.020748304,-0.022963457,-0.018433914,-0.06720963,-0.029291978,0.054682843,0.0063739005,-0.04408833,-0.059248056,-0.048499994,0.058016587,0.057479195,-0.0036470417,-0.0153573565,0.06528513,-0.04890587,0.058821272,-0.014908648,0.048214357,-0.03322567,0.038295545,0.02326414,0.0039801574,0.037610274,-0.060836595,-0.058144968,-0.018804044,0.015285355,-0.09683346,-0.09797909,-0.10199472,0.036860622,0.0045079086,0.008818437,-0.023116319,0.043492533,-0.0039338665,0.028598767,-0.08082844,-0.09743547,0.064640544,0.03797123,0.033162486,0.006366792,-0.059494715,0.0702701,-0.017657518,-0.10369654,-0.029863603,-0.052970514,-0.045880526,0.06414775,0.08213864,0.025143256,0.042413943,-0.068107784,-0.03475433,-0.08342489,-0.02409439,-0.031870056,-0.0465382,0.059883915,0.112145506,0.0015660189,-0.021716924,0.029798428,0.029070321,0.020191895,-0.031619877,-0.014916469,0.039934367,0.010761326,0.032734074,0.019072639,-0.021563971,-0.004365329,-0.016456181,-0.08662576,-0.027559016,0.018750137,-0.04440091,-0.019469418,0.08026941,-0.01898803,-0.07958315,-0.048624467,0.01646563,0.05336594,-3.8793635e-33,0.10657169,-0.08711882,0.060725912,-0.11595487,-0.048690666,0.026854211,0.07013775,0.022864817,0.039611734,0.008908001,0.044993635,-0.044932958,0.07025406,-0.077020526,0.017002719,0.007832148,0.0200879,0.039393745,0.059762925,0.020105375,0.014913731,0.07847947,0.029676007,0.027158523,0.072045416,-0.008587314,0.027600907,0.03920574,-0.027439255,0.069623224,-0.011249797,0.007187178,-0.040068123,-0.04215975,-0.11137083,0.024675129,-0.06448226,-0.020158257,-0.022039438,0.036233738,0.030878058,0.05329228,0.08861804,0.023970932,0.04058171,0.033180837,-0.04938667,-0.027640028,-0.016342368,-0.0935143,0.099627435,0.039646637,-0.0041923523,-0.020039352,0.033218753,0.06662961,-0.023277095,-0.0062232628,-0.05461297,-0.019066438,0.004497936,-0.08229428,0.006826439,0.032788593,0.06612966,0.064661905,-0.02453587,0.006879043,0.027386958,0.021479592,0.04808802,0.019139277,0.0074452674,0.08528309,-0.040209003,-0.032426644,-0.09675507,0.058162805,0.008422547,-0.032482244,-0.030699715,-0.020512074,-0.0043827584,-0.042919997,-0.037250284,-0.043195184,0.03343916,0.09404424,0.0076713343,0.06932094,-0.055843554,-0.02856865,-0.07829686,0.058915418,0.05580276,-4.585067e-08,0.03103858,-0.0590334,0.062475987,-0.0155546535,-0.0039267396,-0.0056460807,0.066015825,-0.011148721,0.07147254,-0.02256758,-0.014836957,0.07704358,0.06609203,0.013649788,0.05562557,0.05971824,-0.035536624,0.014585939,-0.011131226,-0.04213886,-0.009269491,0.009603524,-0.10149353,0.04948548,0.040933404,-0.026803732,0.05151715,0.025694748,-0.05448386,-0.017795842,0.01456672,-0.03166195,-0.03371949,-0.09465534,-0.010601392,0.05650095,-0.04221174,-0.08316213,-0.026840381,-5.3000138e-05,-0.023299217,0.045426514,-0.050986007,0.041968815,0.06034234,0.03677403,-0.007229807,0.0016207265,-0.041452054,-0.009947557,0.068967246,0.002796286,-0.034473073,-0.11101044,-0.13279831,-0.036051236,0.0068619633,-0.059872106,0.0046352725,-0.045409217,0.086584695,-0.011122263,0.2108652,0.025392259 +2.7.1.163,"Phosphorylates the antibiotic hygromycin B. Whereas the enzyme from Streptomyces hygroscopicus (EC 2.7.1.119; hygromycin-B 7''-O-kinase) catalyses the formation of 7''-O-phosphohygromycin B, this enzyme, found in Escherichia coli carrying a plasmid conferring resistance to hygromycin-B, forms 4-O-phosphohygromycin B.",384,0.99999994,-0.03580392,0.025676403,-0.12485203,0.0008062029,0.028900223,0.01205269,-0.039027628,0.070431136,0.11417212,-0.0365451,0.0014602507,0.023198647,0.080271594,0.06432219,-0.025533522,-0.012228818,-0.08294973,0.044402175,0.007585761,-0.06518686,0.090744935,0.029555699,0.05599978,0.039191116,0.037790816,-0.0763557,0.02933249,0.11383718,-0.08479516,-0.063588575,0.023797696,-0.01968671,0.018140346,-0.03450916,0.07719173,0.053912282,0.03802537,-0.09569026,0.069016226,-0.010962359,-0.030413453,-0.013411272,-0.01480364,0.057653416,-0.05000876,0.027959408,0.019270137,0.016365033,0.047509644,-0.024486618,-0.07227369,-0.053710748,-0.06200301,0.094469525,0.08050133,0.07912239,-0.082831375,0.003074398,0.058904324,-0.019476544,-0.018285254,-0.07956525,0.09726974,0.07492446,-0.08934489,-0.049704425,0.014176644,-0.08211494,-0.027492205,-0.0047559654,-0.058924466,-0.0055337846,0.043074515,0.046139754,0.05836259,-0.013691886,-0.046027042,-0.020569118,-0.010921037,-0.07401064,0.0780087,-0.027479433,-0.008367425,0.09655049,-0.030131998,-0.04769138,0.01594286,-0.017217238,0.04348316,0.0026132436,0.06907763,-0.040922664,0.003036511,-0.09428545,-0.019561619,-0.03950261,-0.04393419,0.034022883,-0.022617394,-0.055135556,-0.04549513,-0.030741123,0.049820747,0.04437309,0.03470911,0.0013263634,0.060119078,0.048722077,0.027355552,-0.044647764,0.023136228,0.012041132,0.035023082,-0.028215554,-0.04704136,0.059889216,0.08606245,-0.058558557,-0.12482566,-0.060848687,-0.009815323,-0.033816,0.020056762,-0.026416695,-0.03349744,0.01566033,-0.09436586,4.398535e-33,-0.009532593,0.06174374,0.01913979,-0.08512451,0.037506387,-0.08871337,-0.0014893658,-0.04388006,0.006636306,-0.05471433,-0.081643775,-0.027383924,-0.010371775,0.0415357,0.01810204,-0.03478319,0.021247882,0.05995838,-0.04698854,0.059095114,0.068030514,-0.0111347055,-0.007884093,-0.0014211871,0.07942447,0.052021753,-0.029421637,0.002149338,0.07342629,-0.031767704,0.0010282838,-0.022009265,0.013571072,-0.0025072738,0.036032483,-0.10464444,-0.10109689,-0.03438802,0.10378625,-0.02565707,-0.06379436,-0.04416567,-0.06189959,-0.0019503405,0.04011698,0.0019333767,-0.066407904,0.05337251,0.061172232,0.08136843,0.083985195,-0.03276467,0.022690892,0.015122312,-0.0336543,0.017186899,-0.03791324,0.0045186975,0.07274453,0.0024372512,0.03465903,0.03727822,-0.00096881157,0.03699062,0.031400897,0.007885123,-0.06930919,-0.038093407,-0.02898547,0.080261655,-0.023908466,-0.03954501,-0.078897685,-0.0028150955,0.033817735,-0.019898001,-0.03511263,-0.0027678437,0.045951553,0.012862885,0.018032376,0.013655107,0.0255161,-0.0071198293,-0.052125644,0.026448054,-0.0024645668,-0.08861092,-0.009576307,0.045139365,-0.01793708,-0.08691267,-0.0022792364,0.031813115,0.04625988,-6.240687e-33,0.122486725,-0.045112886,0.13517268,-0.047316838,-0.056363553,0.12935036,-0.04145932,-0.022790749,0.02986952,-0.026836466,0.023186706,0.033906445,-0.088031635,-0.05652207,0.032148015,-0.047468316,-0.010391206,0.096516564,-0.049911615,0.011547185,0.002785336,0.04461892,0.003020356,0.00033541932,0.050423738,-0.017634334,0.0006884019,0.049599506,-0.0139208445,0.036817588,0.004399568,-0.039306395,-0.059665393,-0.01113262,-0.008499297,0.038511153,-0.016190307,-0.017718587,0.0062110997,-0.027841985,0.028497063,-0.052249108,0.025336241,-0.024971211,-0.041467734,0.05628253,-0.057172105,0.057746474,0.030667946,-0.0529133,-0.009252873,0.08847859,-0.026335904,-0.009686948,-0.0054087653,0.03540488,0.02592466,0.006465216,-0.0053201965,-0.07989136,-0.07975904,-0.097730264,0.05056879,0.09458408,0.04277947,0.0412031,-0.007939859,-0.021191953,0.115205556,-0.03287731,0.001397828,0.060526736,-0.026074873,0.018944357,0.010483056,0.053076435,-0.06957629,-0.09011513,0.007334697,0.049377296,-0.024657955,0.02518118,-0.010906959,-0.043788318,-0.02723714,-0.051085204,0.050011825,-0.013530405,-0.0023839676,0.009039912,0.05254212,-0.034311246,-0.014169444,0.0023986672,0.04040425,-4.2909498e-08,0.0033047332,-0.008334934,0.07783558,-0.06257728,0.05499272,-0.05351856,-0.024399964,-0.008504466,0.025233356,0.0067967335,0.010166434,0.021236409,0.04520129,-0.035651702,-0.028873485,0.015322336,-0.092958845,-0.0062244106,0.03340196,0.014304545,-0.027541645,-0.066216245,-0.0900379,0.12683041,0.09710584,-0.039299823,0.0013825411,0.002646542,-0.045190718,-0.0017896928,0.07437503,-0.050677642,-0.071000494,-0.005039622,-0.0033907695,-0.046899226,-0.100641795,-0.011096368,0.0036308097,0.012335977,0.04318115,-0.028443536,-0.0013126486,0.033826236,-0.08479663,0.086105816,-0.05298754,-0.03616279,-0.06391424,-0.0069628325,0.07987409,0.009311162,-0.024591623,-0.04082721,-0.14369605,-0.018105963,0.033827685,-0.01945338,-0.013048367,-0.07116008,0.027633442,0.003892811,0.18569721,-0.006332874 +2.7.1.164,"In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase).",384,1.0,-0.027284857,-0.07918792,-0.10403697,-0.038677227,0.038966812,-0.054099668,-0.060653795,0.0029034808,0.05128719,-0.020414323,0.07549912,-0.04477748,-0.027690992,-0.047913216,-0.046463378,0.045837812,-0.064174935,0.020711878,-0.006308763,0.009602263,0.0028392011,0.050329454,-0.058626007,0.03193821,-0.009985848,-0.07396427,0.096064985,-0.08504658,-0.08687762,-0.038167,-0.020882998,-0.12607819,0.082879685,-0.023555249,0.048718646,0.06343784,-0.06996688,-0.058659837,0.042734347,-0.012160288,0.019418243,-0.05137781,-0.0020886122,-0.045887016,-0.10663718,-0.029541522,0.045410838,0.015573955,0.0018605979,0.036009908,0.011911242,-0.014947949,-0.1738822,0.013555916,-0.048058894,0.11912419,-0.07136157,0.030951668,-0.02397637,-0.003277522,0.011906807,0.0423047,0.043760084,-0.024152232,0.08423173,-0.06515436,0.09633089,-0.019384615,0.053974375,-0.011604918,-0.042242866,-0.025281077,0.031807005,0.08371725,-0.03724688,0.074904256,-0.023429481,-0.004282017,0.019624535,-0.0045248545,0.008233753,-0.046294034,-0.0287386,-0.014218276,-0.0035663494,-0.004759566,-0.009868813,0.07889354,0.024091423,0.02867379,0.12172939,0.00863894,0.058843743,-0.06262771,0.008262842,0.06996322,0.06431385,0.07449241,0.01932832,-0.057740387,-0.051768117,0.043975495,-0.006418096,-0.05034049,0.0054370617,-0.063785635,-0.00052594196,0.054044306,0.00096243876,-0.016238319,0.056752007,-0.041322514,0.041319367,0.0006183983,0.019594898,0.096681416,0.05935768,-0.007317064,0.01599519,0.050003193,-0.05834427,0.050950594,0.027991522,0.054831028,-0.028268352,0.06547989,-0.08154158,3.5413553e-33,0.035611756,0.011366284,0.07737222,0.004688192,-0.021929242,-0.009648727,-0.068261795,-0.0035080176,-0.034875963,-0.08195736,-0.09983505,-0.081189275,0.073025376,-0.05295062,0.018213918,-0.04304091,-0.020124866,0.009655614,0.038502276,0.0047974577,-0.024763115,0.028354313,0.07308227,-0.005259269,0.014968621,-0.009803651,0.013960412,-0.011869586,0.028501183,0.02359183,-0.018401235,-0.059520748,-0.10842934,-0.018930705,0.15900238,0.013140458,0.009348671,-0.0038898636,-0.09185471,0.008182191,-0.0098226,-0.001050244,-0.028218672,-0.03280595,-0.017356021,-0.030568358,-0.026390795,0.09822047,-0.0028503234,-0.0072163814,-0.04243176,-0.060984734,0.05349817,0.022678608,-0.01600012,-0.055588048,-0.0038043414,-0.07375063,0.107594416,0.06461987,0.02739803,0.041272454,-0.05736315,0.06891012,0.0066831005,0.004330262,-0.08446975,-0.021963906,-0.01745689,0.004441049,-0.042388134,-0.04778526,0.014381153,0.026782408,-0.0045362944,-0.031078847,-0.105718344,-0.04217165,-0.067589045,0.02300495,0.027846476,-0.028078377,-0.004473435,-0.02764178,0.015727356,-0.020076105,0.002501184,0.025495918,-0.027322141,0.0354483,0.033185277,-0.03099632,-0.029914888,0.03486809,0.018938048,-4.899084e-33,0.07164853,-0.13329975,-0.010257112,-0.053134512,-0.038802832,0.04781408,-0.002140833,-0.05790833,0.020834383,-0.02208968,0.051764432,0.036572807,0.013047254,-0.07099023,0.039261576,-0.10085036,0.032269303,0.046383936,0.050173607,-0.03166059,0.05973951,-0.05718524,-0.00976426,0.029613428,0.050822373,-0.056565125,-0.0013912172,0.12367774,-0.047267683,0.07422339,-0.026803479,0.013177318,0.004284134,0.07453729,-0.12851991,0.030051878,-0.031854026,-0.017253043,0.10690555,0.009236912,-0.007427784,0.03476224,-0.011031905,0.044014383,0.020481667,0.04584156,0.0055680717,0.10007684,-0.018602965,-0.069697686,0.1172219,-0.053198826,0.006727404,-0.016830798,0.040058218,0.04432429,-0.037359856,0.05263264,-0.030686008,-0.031197667,-0.09637664,-0.065813944,0.0048402497,-0.007225742,0.055783056,0.005930855,-0.0067250645,0.06770272,-0.024163485,-0.01300034,0.031689227,-0.002954786,-0.01846907,0.025146693,0.02256753,-0.10399904,-0.034540396,0.024323959,0.057866085,-0.042870827,-0.063470095,-0.031032298,0.1074263,-0.074324936,0.03732753,-0.05473605,0.02007213,0.090928644,-0.013310188,0.07049076,-0.033563867,-0.053335935,-0.0032549866,0.08258213,0.09369113,-4.097732e-08,0.012320436,0.0015437164,0.031298652,0.0030513378,0.1052074,0.05995675,0.045937836,0.0713439,0.058351543,-0.034760803,-0.048794873,0.036145482,0.019575408,0.023948262,0.021369576,0.082766056,-0.0300984,0.09174841,0.0050470456,-0.0089939535,-0.018316168,-0.040736586,-0.077175595,0.047257867,0.026843427,0.0013565163,-0.019311067,0.026207985,0.007371274,-0.0399823,0.02950936,-0.094773024,0.0031803155,-0.06445214,-0.07314101,0.009032941,-0.04956923,-0.049069572,0.013512185,0.046846475,-0.033293813,0.05510317,-0.05529316,-0.015209529,-0.007985396,-0.013431069,0.0062959483,0.0827755,-0.08354515,0.013308973,0.06282572,-0.028974866,0.003300592,-0.03553981,-0.025119347,-0.02041951,-0.0040663397,-0.07678772,-0.05068861,0.039919574,0.04703079,0.037075397,0.11967233,-0.0039420314 +2.9.1.2,"A pyridoxal-phosphate protein [4]. In archaea and eukarya selenocysteine formation is achieved by a two-step process: EC 2.7.1.164 (O-phosphoseryl-tRNASec kinase) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase.",384,1.0,-0.035958465,-0.09169667,-0.09415769,-0.077966556,0.047808804,-0.039557215,-0.036077756,-0.017268766,0.055078518,0.0064940546,0.06900066,-0.022432849,-0.041906968,-0.018958565,-0.05991928,0.05279018,-0.078816086,0.015165076,-0.004978515,0.0052560912,0.04954618,0.057287723,-0.040475164,0.036272973,-0.006869491,-0.035954013,0.089442745,-0.061353166,-0.08417321,-0.049530264,-0.029617444,-0.09697176,0.067673735,-0.06061705,0.05958114,0.085501015,-0.10598891,-0.039877906,0.047890246,-0.03159134,0.038755026,-0.0748407,-0.009205219,-0.024417317,-0.14949061,-0.015062921,0.06238379,0.035532046,0.040812507,0.021308197,-0.028958293,-0.005843128,-0.15964456,-0.0117911175,-0.044711646,0.105647944,-0.03299043,0.02488298,-0.028443528,-0.03314574,0.0064490465,0.021316653,0.052960806,-0.009461756,0.058574043,-0.052127786,0.069062114,-0.024210975,0.035475295,0.004201847,-0.041584786,-0.010219639,0.077983566,0.062060017,-0.041191503,0.10702745,-0.029961066,-0.0015856004,-0.014274461,0.0094106,0.017442718,-0.038707037,-0.012710824,-0.0051286784,0.015311562,-0.019237528,-0.016930236,0.059034523,0.022550778,0.00021113535,0.14081444,0.016444447,0.069157764,-0.043291375,0.010449911,0.0792186,0.060825877,0.053705458,-0.011834195,-0.072282284,-0.058820404,0.024735665,0.0013945283,-0.04783028,-0.015657159,-0.046425685,-0.03288667,0.049344372,-0.0023474267,-0.013675185,0.022450704,-0.022923434,0.036047272,0.016893249,0.022137411,0.078501865,0.061931733,-0.0043372377,-0.007192442,0.061055604,-0.055361688,0.031908046,0.02185295,0.07314538,-0.025864802,0.043646842,-0.08379554,3.843859e-33,0.053864744,0.048077364,0.06766159,0.006784678,-0.0029023876,-0.024824005,-0.067070805,-0.022083465,-0.05458161,-0.05725921,-0.08076241,-0.0789798,0.08360939,-0.054092996,-0.0019730767,-0.037619956,-0.038670868,0.021366172,0.053830743,0.010007904,0.0025008684,0.038610984,0.064480186,0.013504639,-0.0054187207,0.031467278,0.019490467,-0.006836633,0.032258622,0.02282149,0.010586219,-0.08889005,-0.11959993,-0.040519096,0.16303656,-0.023078363,-0.019258237,-0.02318195,-0.11016404,0.003928555,-0.030031886,-0.01626019,-0.03192527,-0.015327752,-0.029920893,-0.059635136,-0.02204962,0.105521806,-0.014962716,0.014461101,-0.021988122,-0.06945842,0.053668693,0.027555026,-0.060777456,-0.06726192,-0.018064734,-0.07190959,0.09570933,0.05082864,0.054930788,0.029845977,-0.054394238,0.04103565,0.00025673676,-0.02773013,-0.04644362,-0.039249897,0.008926616,0.029435234,0.0012993027,-0.043932937,0.024685107,0.051146567,-0.010899002,-0.026452798,-0.090943806,-0.045539536,-0.06942966,0.050454766,0.028781865,-0.055403717,-0.008353041,-0.036560997,0.008585491,-0.022354737,0.0027945102,0.0076472852,-0.025290072,0.0344712,0.03170664,-0.048114765,-0.029168421,0.042663436,-0.0022225373,-5.0805964e-33,0.08744425,-0.1252011,0.04149202,-0.04839883,-0.053447884,0.033867557,0.020357052,-0.029806012,0.020042405,-0.02985369,0.058184654,0.03796696,-0.0031147168,-0.061967887,0.028400928,-0.08298022,0.034042716,0.023752227,0.06000473,-0.012041967,0.056690764,-0.04659218,-0.014765711,0.04951868,0.046214387,-0.029691713,0.0010806128,0.09779958,-0.07772975,0.07020633,-0.011436083,0.049205348,0.01060879,0.05549053,-0.13495235,0.017149616,-0.07732846,-0.014456154,0.102243595,0.022694325,0.017936943,0.044301488,0.022798887,0.0104267625,0.0063740388,0.011530145,-0.008054145,0.0912978,-0.018710032,-0.06279213,0.09738409,-0.0034822768,0.004181042,-0.027863247,0.06779956,0.04404541,-0.043627355,0.05317417,-0.021590713,-0.011777735,-0.06760211,-0.0888676,-0.0014524072,0.020164311,0.06610067,0.045145236,0.014540827,0.059370276,-0.020651024,0.0208055,0.024397442,0.007326501,-0.0044678366,0.057544794,0.0075437096,-0.07891221,-0.038346298,0.03900884,0.052958086,-0.030803597,-0.05298116,-0.038759287,0.07812778,-0.09382635,0.026432324,-0.053098414,0.03810243,0.08096892,-0.017745996,0.054229036,-0.014433626,-0.052746713,0.011692631,0.058162965,0.11489984,-4.2801812e-08,0.025659971,-0.0053475504,0.02473581,-0.013761394,0.08996887,0.034501746,0.056958873,0.041635714,0.06898399,-0.03986101,-0.0260156,0.0064297253,0.032160882,0.037520632,0.034222987,0.097022325,-0.036772333,0.068843134,0.016928641,-0.02584535,-0.011561949,-0.02265354,-0.112796314,0.039300982,0.059073146,0.010985174,-0.0073104557,0.02739022,0.0010312357,-0.0352725,0.050596803,-0.10149313,0.00981049,-0.07567396,-0.06657605,0.028574776,-0.06126882,-0.06855368,-0.013169695,0.037153345,-0.053200554,0.054865506,-0.03288514,-0.035063386,-0.01407266,0.027796388,-0.013617272,0.081382915,-0.08421516,0.0053019524,0.07951993,-0.024750674,-0.010225756,-0.059116695,-0.062806405,0.011762658,0.023294007,-0.063134976,-0.06073814,-0.00795635,0.03336836,0.0087148445,0.09953332,-0.03731257 +3.1.26.13,"Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication. To perform this task the enzyme combines two distinct activities. The polymerase domain (EC 2.7.7.49, RNA-directed DNA polymerase) occupies the N-terminal two-thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third [13,14]. The RNase H domains of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites [15-17]",384,1.0,-0.067641124,-0.032122985,-0.035000023,-0.051025763,-0.025962831,-0.034344528,-0.059935555,0.027190547,0.046372265,-0.003455448,-0.04380262,0.04520666,0.056879833,-0.012139166,-0.05795222,-0.006670405,-0.0833453,0.048130967,0.02886662,-0.0020062765,0.066582255,0.010090898,0.024469877,-0.057969972,-0.04090543,0.0367851,0.026815139,0.065716,0.002374214,-0.006182344,-0.019991267,-0.04102229,0.042504285,-0.025632694,-0.038409222,0.082206845,-0.015672106,-0.034166627,-0.0034998949,0.067264415,0.05707781,0.036567684,0.034374766,0.009677481,-0.0013924553,-0.013374595,-0.004162487,-0.010208674,0.031467415,0.057432678,0.052061457,-0.041122682,-0.01927045,-0.017315967,-0.07681399,0.08847791,0.0025178103,-0.002899915,0.034092914,0.03035266,0.05541935,0.016826555,-0.0009433244,-0.013478114,0.06452675,-0.08422229,0.010074697,0.07387748,-0.0529766,-0.0217756,-0.06623792,-0.04654756,-0.13945113,0.03152537,-0.023066953,0.032483917,0.014440946,-0.09207464,0.029808186,0.0013419702,-0.007964585,-0.04543483,0.07183223,0.029290171,-0.04449269,0.034068312,-0.028126288,0.017169295,0.03712197,0.085866585,-0.027764356,-0.07057414,0.061708007,-0.03787834,-0.03787009,0.063908,0.058356933,0.055461545,-0.01622162,-0.027162632,-0.038658503,2.1223224e-05,0.028173774,-0.06379123,0.04698793,-0.020829035,0.018877607,0.06343905,-0.03976957,-0.0634794,-0.040544447,0.089529194,0.08472784,-0.037257694,0.08147367,0.020198347,-0.010159299,0.011958472,0.0070408233,-0.054607347,-0.045524195,-0.0228948,0.07917927,-0.00047035422,0.03837382,-0.06154413,0.047672123,2.20518e-33,0.044031072,0.017593876,0.063566886,0.002881207,-0.02404476,0.090056226,0.0049112965,0.022900991,-0.09485154,-0.023546498,-0.005717184,-0.08319517,0.051815633,0.04588445,-0.08447286,-0.034842327,0.021140097,0.061735757,-0.07048398,0.014522733,0.057632957,0.05658569,0.021530291,0.013156265,0.06928262,-0.013703951,-0.040162284,-0.007007133,0.033118155,-0.051319797,-0.010999249,0.06332904,-0.02782611,0.03260433,0.0235329,0.018584823,0.010610371,-0.02462638,0.025942128,-0.004852562,0.025867496,-0.0388436,-0.0037850658,-0.053338964,0.06975421,-0.056719128,-0.028542792,0.017647753,-0.040220622,0.029490171,0.097857036,0.058796756,-0.0070123896,-0.072273746,-0.047284134,-0.0006556771,-0.042124424,0.036518466,0.029765762,0.036114465,-0.0076914453,0.033429243,-0.023891306,0.04954379,-0.0054783514,-0.017342266,-0.01319691,-0.15817797,0.045515176,0.17159735,0.02929333,-0.028806837,0.041446634,-0.008682947,0.059572376,0.033582237,-0.14480752,-0.106964916,0.080349706,0.040087175,-0.10854627,0.008840345,-0.02880104,-0.03353062,-0.0077015096,-0.08308052,-0.003162819,-0.10742825,-0.003870964,0.0403899,0.031514842,-0.02424045,-0.02452884,0.041448217,0.06669108,-2.7726885e-33,0.062177997,-0.07219424,0.04799736,0.0043008123,-0.109740235,-0.026674595,0.06985346,-0.038033873,0.012235866,-0.016827269,0.082564056,-0.029445432,-0.0017588398,-0.028899806,0.052376274,0.04373665,0.04175181,0.07650147,-0.009196811,-0.035039444,0.010744574,0.041324418,-0.016625708,0.10178653,0.03452276,-0.06434812,0.019616148,0.05556008,0.043826103,-0.023982625,-0.036845997,0.0010095194,0.076342985,0.059054613,-0.021718731,0.010764988,0.007358475,0.00348773,0.013727311,-0.07737414,0.04276586,-0.012113114,-0.057418447,0.11987128,-0.0063158474,0.0901341,-0.061899714,0.06757812,0.124142125,-0.059758134,-0.018741073,-0.077108294,0.06642165,-0.016992094,0.06194272,-0.045714274,-0.028549237,0.014302484,0.06772182,-0.0017717821,-0.032084085,-0.001700265,0.055094138,0.03010898,0.011639051,0.08017754,0.021816324,0.041029587,-0.015711414,-0.15699638,0.088081695,0.025389904,0.022704313,-0.06862472,0.03273273,-0.11744566,-0.020434361,-0.024811681,-0.04517149,-0.038797908,-0.03799686,-0.03335802,-0.005586689,-0.029600669,-0.012423641,0.012598967,0.0032392493,0.07462524,-0.017852906,0.032293484,-0.026799874,-0.018599238,-0.043219853,-0.049469482,0.043974645,-3.7779582e-08,-0.004909669,-0.0068590958,0.067377344,-0.09318861,-0.042973388,0.06755322,-0.016742906,0.03211059,0.0545087,0.023448057,0.037822824,-0.02044781,-0.044651125,-0.032437634,0.054024264,0.034090016,-0.075132705,0.03391556,-0.016138256,-0.00655146,-0.0062154545,0.061317716,-0.103505775,0.013136593,-0.056643523,0.005307354,-0.0011838562,0.03640232,0.05598965,-0.08488582,0.05738652,0.0021085015,0.06432872,0.008217612,-0.10548643,-0.030232718,0.1068403,-0.035397027,0.032283276,-0.043762535,0.011451966,-0.086161576,0.004861538,-0.035149217,-0.0605558,0.007040588,0.03349906,0.07543647,0.05530291,-0.10591525,0.022142783,-0.0022695388,0.022979964,-0.057060376,-0.013240396,0.04048498,-0.052665133,-0.09271619,-0.0003547857,0.0062450245,-0.006605427,-0.061873272,0.14382051,-0.07672115 +3.2.2.27,Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. EC 3.2.2.27 and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA.,384,1.0,-0.07444053,-0.01718853,0.0035659508,-0.026458051,-0.053168055,-0.045457948,-0.08017824,-0.022874342,-0.012753905,0.0034055691,0.074442156,0.102270216,-0.09338346,-0.007520034,-0.07931889,-0.014812879,-0.101491444,0.06480461,-0.019310053,-0.06201181,0.101903565,0.06055404,-0.009879948,-0.034992263,0.026707476,-0.017891437,0.0137687,-0.032090943,0.004100338,-0.11223113,-0.01458511,-0.058469824,-0.039085563,-0.09309614,0.07738565,0.062763005,0.011850114,-0.025066718,0.015912166,-0.01531343,0.023389652,-0.018303882,-0.005386645,0.015404594,-0.057919074,-0.0003461997,-0.017652629,0.01265485,0.0025604423,0.013060187,0.020893639,0.020377511,0.010135347,-0.007032064,0.05304193,0.04090844,-0.074617326,-0.026471477,0.019645551,0.03128036,0.07755482,0.03054258,0.0041153403,-0.019087031,-0.02082538,-0.025223762,0.12074492,-0.11537398,-0.020606276,-0.016459914,-0.07899367,-0.08289987,0.024916714,0.04257539,-0.016042221,0.04349696,0.00211655,-0.06985549,0.0072852946,0.050317008,0.01111008,-0.08687769,0.06866661,0.037536044,-0.003702443,-0.045504455,0.072406165,0.015137146,0.03618739,0.025088161,-0.020083476,-0.05657596,0.066887654,-0.07344428,-0.02207892,0.02373994,0.011240913,0.046059594,0.0036001008,-0.06866774,-0.00070248195,0.007373323,0.02169566,-0.10021363,-0.020596642,0.047712356,-0.036593974,0.09511073,0.11247353,-0.0062744543,-0.049263716,0.10108566,-0.025941739,0.0164774,-0.12577224,0.0001404038,0.032410305,-0.055739105,-0.048414674,-0.009873778,0.01794975,0.013363656,0.04019628,-0.012254922,-0.035417765,-0.00047002215,0.03593224,1.5753415e-33,-0.009739943,0.057821978,0.019214993,-0.009234265,0.005757515,-0.01443245,-0.024514407,-0.014884093,-0.07147237,-0.06657318,0.026653185,-0.008276742,0.021813152,0.098562695,-0.09250342,0.043367155,-0.002301246,0.013454499,0.003870563,-0.045557432,0.006513901,0.110615544,0.048400234,-0.04089241,0.06710184,0.045305174,-0.010618248,0.0386379,0.07743306,-0.005947399,0.07891472,-0.07439369,-0.021645483,0.076527014,0.07654916,0.0788149,0.018022709,-0.0726194,0.05994274,0.033787534,-0.07331093,0.012107464,0.03392635,-0.07920132,0.025950104,-0.029878989,-0.015758507,-0.01262891,-0.059215207,0.06699314,-0.014293943,-0.028269863,0.016464474,0.023650538,-0.04554522,0.020299949,-0.030496115,-0.0525969,0.008468147,0.084880315,0.004953444,0.07926362,-0.023345832,-0.050158627,0.046279203,0.0070949425,-0.0261443,0.006096197,0.022673504,0.029711258,-0.021102613,-0.039014146,0.059362233,0.032231413,0.029530799,-0.040288232,-0.058805905,-0.006896324,-0.03699149,0.02067363,-0.017964296,-0.030681953,0.007953699,-0.021618847,-0.040689595,0.006848664,-0.07000783,-0.033325795,0.026922558,0.040585473,0.024757963,-0.016128542,-0.056871668,-0.0038178049,0.014772716,-4.6002303e-33,0.17932174,-0.1104159,0.11371472,0.023144232,-0.010727084,-0.05812171,0.059018187,0.018552873,-0.0076418193,-0.021258866,0.027723769,0.0018250218,-0.0009953901,-0.0883237,-0.0081343455,-0.027741399,0.034239035,0.01604036,0.011330385,0.0029997795,0.0051204027,0.061785568,-0.033444114,0.08169102,0.055624466,-0.0104722865,0.01816872,-0.038997736,0.05468067,-0.03865902,-0.05379767,-0.010533635,-0.018356746,-0.045214977,0.040392283,0.08113855,-0.017414445,0.030257741,-0.009954313,-0.096407466,-0.020554256,0.05228238,-0.035848398,0.03874944,0.07676302,0.064833455,-0.0772703,0.03892118,-0.05159119,-0.060701434,0.038518745,0.017065318,-0.0027795082,0.03509241,0.049374428,0.017921528,0.0051133507,-0.011443144,-0.07096483,0.08588277,-0.05676907,-0.02528464,0.048709016,0.0023925907,0.06787441,0.0025378247,-0.07551429,0.043931473,0.012869225,-0.041969135,0.052961275,-0.02273443,-0.009408286,-0.032365605,-0.0069271177,0.01706681,-0.11719413,-0.0518429,0.04097163,-0.05356915,0.10514416,-0.048885856,0.00069284637,0.031598866,0.062095355,-0.044534847,0.05165637,0.11458914,-0.04503974,-0.035834063,-0.07607241,0.0053026346,-0.07044571,0.04042929,0.049039423,-4.2716113e-08,0.046762347,-0.024707068,-0.006868277,-0.08723851,-0.044385426,0.057727844,-0.013298264,0.11959243,0.059182897,0.046452504,-0.005768475,0.053728607,0.0020021803,-0.026054215,-0.013072204,0.024178836,-0.100440025,0.05936841,0.019531362,0.07127862,-0.109639734,0.038077373,-0.16393256,0.048278064,0.018668197,0.001633709,0.06654421,-6.6685156e-05,-0.111902595,0.0029484234,0.017222863,-0.047337502,0.029080885,0.016415762,0.0109035615,-0.036097605,-0.011760206,-0.04583716,0.005072866,-0.027753012,-0.0040980824,0.033035662,-0.015624743,-0.013710432,-0.030075558,-0.026855163,0.0049119685,0.017340472,-0.12029167,-0.0147532215,0.060423814,-0.02774912,-0.033801336,-0.14568152,-0.052928306,-0.017363777,0.03547481,-0.077976085,-0.025828408,0.04953823,0.048625626,0.008767078,0.15230127,0.00025986103 +3.2.2.28,"No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N4-ethenocytosine residue [2], significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing E. coli [3]. Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. Uracil-DNA glycosylase (EC 3.2.2.27) and EC 3.2.2.28 form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA.",384,1.0,-0.059784677,-0.020487487,0.010374204,-0.034814365,-0.03950126,-0.045337576,-0.080612324,0.028666476,-0.0009843823,-0.01776071,0.07227656,0.1179018,-0.07194506,0.016341014,-0.08168057,-0.003190621,-0.08000599,0.11335298,-0.023231806,-0.068997666,0.07959784,0.03344099,0.017337698,-0.02277034,0.024658447,-0.042121246,0.0006164066,-0.016072234,0.00452514,-0.10368182,-0.046035457,-0.047842104,-0.06357841,-0.068762794,0.09000385,0.045886844,0.0137001425,-0.026594527,0.061377335,-0.06568209,0.017304266,0.018414984,-0.024863359,0.036233786,-0.05035524,-0.038755223,-0.013608523,0.010818608,-0.014544019,0.00037360453,0.04305894,0.016500287,0.030569604,-0.022901148,0.092902526,0.027016925,-0.06302172,-0.019357026,0.05533444,0.041488796,0.06461596,0.007308549,0.03634261,-0.034874752,-0.014650004,-0.020809425,0.13650273,-0.11973895,-0.014078455,-0.003795303,-0.050477676,-0.054000605,0.013787928,0.057484623,0.027821708,0.05610059,-0.020092864,-0.015743572,0.01218521,0.07257007,-0.03147677,-0.083526045,0.0821491,0.010601623,-0.0033262125,-0.039312642,0.047049645,0.029496826,0.06737074,0.044572294,-0.0052766423,-0.06745977,0.0687025,-0.063675106,0.022448262,0.02532168,-0.02244775,0.014591723,-0.026470026,-0.07480355,0.015753603,0.026525194,0.0067390585,-0.042263415,-0.021048712,0.045905095,0.015886618,0.06937104,0.060722742,-0.04085844,-0.05611064,0.08558715,0.027510667,0.03549677,-0.15755421,-0.021615945,0.03652981,-0.06374173,-0.07757114,0.012840878,0.03863426,-0.04021511,0.027816828,0.033628266,-0.05128574,-0.0022237443,0.036662903,3.2358928e-33,-0.0018437817,0.06025652,0.028610244,0.01367017,0.031674493,-0.009083391,-0.0026881918,-0.032707818,-0.07378567,-0.06356095,0.013379671,-0.050321754,0.059713673,0.05808619,-0.09707165,0.054099847,-0.016813777,-0.00580878,0.0083809905,-0.031039512,0.043479737,0.05562215,0.043408617,-0.078211375,0.06032358,0.036424544,-0.050487295,0.047850683,0.082383044,-0.0065402756,0.038784087,-0.049722005,-0.041495107,0.10002823,0.0726534,0.06629426,0.023281248,-0.074836865,0.06364062,0.08685457,-0.08193805,0.037702918,0.011138748,-0.083559886,0.042804558,-0.03317851,0.01136755,0.016576035,-0.11389948,0.0768035,-0.024511704,-0.015870336,0.0042162137,-0.022518398,-0.025240757,-0.021127203,-0.008591651,-0.04590394,0.020270605,0.043598313,0.0033499426,0.058024965,-0.029749712,-0.072116524,0.042356923,0.001614399,-0.035879053,-0.008094844,-0.0011226378,0.05428007,-0.008700961,-0.060200553,0.025689393,0.029410107,-0.0018352878,-0.070729695,-0.05600404,0.025938064,0.0004628101,7.001697e-05,-0.0064300615,-0.014008238,0.004728337,-0.010419558,-0.06578974,-0.030311413,-0.060484104,-0.011486511,-0.0030432907,0.043319978,0.09039129,-0.025571255,-0.055041693,-0.004231446,0.034337454,-5.572352e-33,0.16750588,-0.12161352,0.10130652,-0.002938681,-0.04859759,-0.0608382,0.062750205,0.0028222823,0.03863095,-0.047162354,0.030431354,-0.0016223046,-0.028832221,-0.07659328,-0.06439161,-0.0043250658,0.0013093975,0.034613676,-0.011356709,-0.009997623,0.015526859,0.043840293,-0.047114078,0.09101372,0.03031189,0.018818635,-0.0074859387,-0.03200564,0.02743594,-0.053239007,-0.055358786,-0.02321238,-0.0160336,-0.039246,0.08122415,0.0901719,-0.007868645,0.038149223,0.02190239,-0.072736815,-0.015563071,0.08209319,-0.024041003,0.029607013,0.07641836,0.07121344,-0.07031867,0.024222655,-0.042393073,-0.073066615,0.058537114,0.02519516,-0.010217309,0.03920599,0.0628049,0.02860903,0.06324008,-0.032277092,-0.098533325,0.10569557,-0.07294395,-0.016097795,0.016156074,0.01605378,0.040623177,0.009143263,-0.09202425,0.060062185,0.05376938,-0.06451022,0.05144655,-0.034004863,0.0074248705,-0.08975681,0.0011712289,-0.017603688,-0.10606068,-0.03747387,0.030266678,-0.0448659,0.06257147,-0.04292574,-0.03189019,0.019711688,0.06397259,-0.011334447,0.037996348,0.13512161,-0.025949238,-0.035144683,-0.061740864,0.0048112296,-0.03727955,0.018187357,0.053408008,-4.7183132e-08,0.023716487,0.0106968265,-0.021675397,-0.06642027,-0.050561305,0.040040947,-0.011114202,0.10352465,0.048829176,0.04110937,-0.0076611415,0.060017526,0.014817479,-0.015975429,0.004189935,0.02183152,-0.11791811,0.0147808725,0.022683125,0.078077406,-0.10186188,0.017218111,-0.14858684,0.036956925,0.026644643,-0.0058774347,0.089992896,0.014986728,-0.057544466,-0.035244085,-0.01001413,-0.091012634,0.0016909225,0.067506224,0.00025627817,-0.036846377,-0.029192807,-0.027376631,-0.0019987803,0.0036259666,0.014712731,0.022930829,-0.00094202,-0.018158559,-0.009131849,-0.008642042,-0.0014797926,0.0047965487,-0.11397847,-0.027115945,0.06821782,-0.038157146,-0.034381814,-0.09946185,-0.046845634,-0.017407445,0.0628532,-0.01966522,0.014774172,0.037959468,0.041114572,-0.017382242,0.07284621,-0.015420453 +3.2.2.29,"Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].",384,0.99999994,-0.0901876,0.05202958,0.06934544,-0.070936166,0.008474041,-0.01386849,-0.029866436,-0.03315397,-0.035592392,0.0013619576,0.047726955,0.13609226,-0.06304241,0.0010249872,-0.053199373,-0.01532719,-0.028192239,0.030154416,-0.042983238,-0.12272214,-0.01325269,-0.008659182,0.003244963,-0.0574806,0.04981209,-0.0038107126,-0.053167373,-0.003450268,0.046514712,-0.101812154,-0.052082747,-0.03508227,-0.045585964,-0.085258655,-0.05731554,0.058320943,-0.015023084,0.04337542,0.04723997,-0.012029295,0.041353017,-0.063093,-0.055959802,0.006642594,-0.03188919,0.064498395,-0.022508463,0.039520185,-0.022740854,0.056880463,0.033373766,0.057896577,-0.047174405,0.082648985,-0.021166027,0.12942722,-0.055416033,0.03163385,-0.0027978683,0.0053688143,0.012008645,0.0055496534,-0.035047024,0.00832749,0.091231346,-0.05910039,0.12339843,-0.07613476,2.17793e-05,-0.013435054,0.02920109,-0.01625132,-0.01613231,0.036724124,-0.026977329,0.018775543,0.0001957063,-0.092469215,0.028750718,0.07018601,-0.0046665943,-0.025291827,0.078314684,0.048530407,-0.0006487191,-0.01724804,-0.0133733,5.9102415e-05,0.052750707,-0.031122737,0.036082704,0.022689495,0.026602905,-0.054156356,0.024688043,0.034309853,0.052192528,0.03324157,-0.014042713,0.008306439,0.02293877,-0.004517473,-0.06736123,-0.0735764,-0.060631126,0.03545301,-0.018384444,0.07375407,0.033974104,-0.016838709,-0.014625355,0.09538306,0.0052858824,0.045257494,-0.1296727,-0.021711592,0.059959196,0.0033330794,-0.018007258,0.010385791,-0.023048727,0.024559153,0.013929859,0.036571346,-0.016634785,0.011467646,0.05945599,2.1428088e-33,0.018412672,0.06369253,-0.020206735,-0.032038372,-0.013799201,0.03626958,-0.044544753,-0.02786974,-0.060517397,-0.0292805,-0.019771224,-0.05505655,0.014825532,0.08526253,-0.07714691,-0.032133035,-0.0032310062,0.023298152,-0.014946366,-0.10908177,0.032903846,0.17357616,0.018304275,0.010573819,0.060900986,0.013693475,-0.015821278,0.05694465,0.015460424,-0.014187417,0.0041376348,-0.0036547612,-0.06516393,0.055073548,0.06804825,0.061125413,-0.0022356191,-0.09261723,0.062414173,0.06449819,-0.051469646,0.05569646,-0.019020556,-0.066409916,-0.003039196,-0.05841187,-0.026882341,-0.057547666,-0.081245415,0.010582414,0.0096337,0.002543967,0.026485238,-0.012379448,-0.07484065,0.01142193,0.040133078,-0.04040288,0.004973458,0.0771575,0.010754799,0.034693923,0.003706918,-0.021315236,0.025340868,-0.04553149,-0.072152846,0.005127093,0.028785104,0.019016882,0.018962706,-0.030560894,0.09044774,0.029507808,0.05643668,-0.03447945,-0.027438132,0.038301263,-0.0363846,-0.04740854,-0.018453207,0.004863274,-0.033353098,0.00015944419,-0.023036776,-0.04215644,-0.028749526,-0.09447739,0.018839154,-0.0169853,0.061789338,-0.0210737,-0.07488596,-0.042592913,0.0030049721,-3.4477653e-33,0.12700431,-0.09943253,0.14677222,0.045668274,0.0058103907,-0.05226829,0.06072411,0.025004337,0.007214585,0.007964684,0.025570495,0.0030760248,-0.04445347,-0.08551492,-0.031666204,-0.010576989,0.07411106,-0.0070406036,-0.04684289,0.030700242,0.017519189,0.06229202,-0.025085049,0.06435776,0.021876236,-0.016151305,-0.009785271,0.02390716,0.06849609,0.009342713,-0.07692084,0.00013922922,-0.0187026,-0.03276024,0.0646741,0.10035782,-0.022017278,0.07121754,0.00094849657,-0.08874342,0.03312505,-0.0010815996,-0.013895506,0.044094358,0.053465508,0.08339335,-0.074204065,0.013113869,-0.08850633,-0.022697438,0.047602605,0.009472807,-0.010908648,0.0021719974,0.07295017,-0.026150225,0.0067003663,-0.12245344,-0.074985065,0.071148284,-0.01529077,0.000813646,0.0074394983,0.030274011,0.059183918,0.02508134,-0.0248026,0.06468455,0.038417783,-0.019017886,0.013569726,0.019959077,0.0919672,-0.057823773,0.00416894,-0.0058117625,-0.05548146,-0.0010882813,0.012668117,-0.029942308,0.021884436,-0.06266758,0.0022405966,-0.097188056,0.027365796,0.020148534,0.021782748,0.10388453,-0.009099761,-0.0046455567,-0.037628766,-0.017459426,0.025191786,0.04134672,0.032618597,-3.7691024e-08,0.10870246,-0.1033306,0.00069252844,-0.06404624,-0.079052694,0.057689317,-0.016737044,0.119203255,0.061075307,-0.030652126,-0.024456289,0.09542402,-0.00056434935,-0.0140318135,-0.007205191,-0.003903492,-0.09025737,0.0142114675,-0.0029594807,-0.029033849,-0.14022759,0.05192483,-0.083089195,0.039769698,0.014955206,0.08156347,0.057673693,0.01809912,-0.06902652,-0.051016804,-0.0019756237,-0.05236341,-0.001842975,0.062540986,0.04769895,0.0023645954,0.0073978286,0.02236946,0.0052434774,-0.016707115,-0.01693795,0.06532191,-0.06112626,0.018922748,-0.013336315,-0.0941553,0.008923925,0.015296005,-0.06328623,-0.031563193,0.045211896,-0.0019120045,-0.11242666,-0.14169537,-0.048108593,-0.022010177,0.0218145,-0.09377971,-0.024038922,-0.04140098,0.004955325,0.00028996653,0.13323082,-0.05932494 +3.4.17.23,"A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2. 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In peptidase family C30.,384,1.0,-0.041832045,-0.042042583,-0.09155524,-0.058420524,0.094079286,0.05993072,-0.02283461,0.059953555,0.06722161,0.03968846,-0.03115598,0.020120624,0.0033334384,0.107041515,-0.0036966747,-0.03420064,-0.13196175,-0.04374947,0.031454667,-0.061842017,0.019243859,-0.007212908,-0.000992331,0.014196419,-0.044603042,0.10126151,0.024929827,-0.08647877,-0.017395034,-0.015052251,0.025998855,-0.11035668,0.04023655,-0.035571437,0.012665798,0.06025062,-0.021557955,-0.026521055,0.013539682,0.010412575,0.064788476,0.040206272,-0.016500195,-0.11925875,0.050312806,0.017540364,-0.034971733,0.022428315,0.112634435,0.030440804,-0.027331935,-0.092393495,-0.06096224,0.02992559,0.027923211,0.09183815,-0.073547296,-0.05059392,0.05801149,-0.010779881,0.0046482123,0.032770757,-0.019169087,0.019392988,-0.02174575,-0.0834043,0.054521777,0.08704977,0.0119179115,0.052931353,-0.013444147,0.058147967,-0.10332815,0.11563449,-0.03542509,0.058510497,0.05180754,-0.04776372,-0.0056831376,-0.02837751,-0.0370263,-0.002967897,0.088461176,0.07227705,0.023299567,0.049799375,0.07835589,-0.011492984,0.10183198,-0.07539941,0.029393677,-0.02528101,0.01313726,0.020595705,-0.057529073,0.015626527,0.0033343092,0.020746984,0.05815318,-0.014115004,-0.005484389,-0.08583776,0.06980921,-0.05945976,-0.0037113982,0.03491853,-0.049324695,0.103417404,0.036919788,-0.0040518246,-0.02179682,0.04952439,0.012588216,-0.041980557,0.068877704,0.081912875,-0.07231865,-0.10775473,-0.06323381,-0.0012227981,0.016111339,-0.048723742,0.012464553,0.025993865,-0.04401084,0.07243077,-0.053451493,2.3545168e-33,0.0060862773,0.03517646,0.076003,-0.010204958,-0.06398689,0.010389616,-0.016177827,0.03669322,-0.037530612,-0.031347964,-0.070023164,-0.024798466,0.033783384,0.02606988,-0.009841636,-0.0009080151,0.03597569,0.028119182,-0.07453061,0.02109368,0.0039456426,0.10039733,0.050262336,-0.071055815,0.036081202,-0.005404894,0.0373333,-0.06724655,0.04193154,-0.030811995,-0.06846397,0.011734614,-0.048960462,0.034684528,0.017234607,0.0020386446,0.038057,-0.046399448,-0.005716698,0.0868652,0.06914429,-0.010662158,-0.070227295,-0.03983278,0.0623442,-0.065369904,0.00050301093,0.0022576456,-0.009970759,0.052756026,0.036441065,0.07497734,0.040223952,0.05413095,-0.039811622,0.021903051,-0.014818961,-0.044906903,0.05482201,-0.02110336,0.027714044,-0.07070698,-0.045445845,0.06201144,-0.04298502,-0.018060554,0.014363539,0.033116274,0.047282435,0.11590528,-0.018848008,-0.009074875,0.014616959,-0.02642364,0.07183251,-0.075111374,-0.07860922,0.022073796,-0.00058889255,0.07311884,-0.118181534,0.05134523,-0.0062970137,0.014212721,-0.11700785,-0.011643329,0.039061945,-0.018722663,-0.11235347,0.02444414,0.035609603,0.022112738,0.06301767,0.08715071,-0.08137749,-3.0628864e-33,0.013956375,-0.105016395,0.03786003,-0.07915615,-0.061030388,0.087833494,0.08388285,-0.060015067,-0.0018500106,-0.0254911,-0.01421561,-0.019067556,0.02303503,-0.05863734,-0.05287958,0.03736992,-0.04545654,0.076103956,-0.024135597,0.010419057,0.04973671,0.020576017,0.039068587,0.034102365,0.006610305,0.016038163,-0.0032546965,0.04088291,0.03591223,-0.039240025,-0.002082991,0.0021708985,-0.038067847,0.039888527,-0.049007896,0.060537953,-0.007987649,-0.012398683,0.04420959,-0.059436813,-0.02131713,0.08231995,-0.044915162,0.07498091,-0.012537324,0.09580897,0.05632258,0.047358382,-0.037003454,-0.08127583,0.00046246743,-0.10328609,-0.006110273,0.018305685,-0.025415191,-0.038993463,-0.012811817,0.01597132,-0.05006333,-0.005348661,0.003950918,-0.03501749,0.032788966,0.021141656,0.050160047,0.028468685,0.015415627,-0.007541072,0.024310911,-0.006714571,0.017030217,0.0040799896,-0.03248382,0.035136178,0.0057839737,-0.0433084,-0.05172464,-0.05400566,-0.032811783,-0.055553693,-0.005754855,0.00035661098,-0.008822134,-0.11119796,-0.01826121,0.023347698,0.028206376,0.0037234172,0.017173018,0.08259604,-0.0416199,-0.035786703,0.05702977,0.0978427,0.031134922,-2.4270093e-08,0.055581048,-0.06286157,-0.014133638,-0.031250637,-0.07764381,0.019755766,-0.049286764,-0.0010392854,0.037157696,-0.012348923,0.02423729,-0.025351984,0.044694755,0.0104282545,0.008965078,0.036501627,-0.037705407,-0.018410953,-0.028564448,-0.015283686,-0.023440033,0.047665246,-0.05527871,-0.0033280319,-0.05147804,-0.029673789,0.006780896,0.0455415,-0.0180249,-0.01796098,-0.093744844,0.017272083,-0.06087995,-0.0014503937,0.08484583,0.06253878,0.096117534,-0.019302486,-0.00984748,-0.0034624399,0.079104505,-0.04114951,-0.081115246,-0.03396976,-0.02071279,-0.010850903,-0.0883289,-0.09018682,0.041153643,-0.011866379,0.048222493,0.008692412,-0.043185685,-0.10989145,-0.09851996,0.020940637,-0.061752513,-0.099724516,0.017786996,-0.07562283,0.05107058,-0.056873605,0.13976477,0.009853538 +3.4.22.70,In peptidase family C60.,384,1.0,-0.014170749,0.028901746,-0.12933397,-0.01688262,-0.0522501,0.07942785,-0.032643378,0.08072242,0.020335067,0.044748712,0.11446201,-0.052556235,0.006880333,0.0141410455,-0.038834654,-0.030146698,-0.098085426,-0.022937905,-0.045479182,-0.057575677,-0.038645968,0.003074204,0.052817337,0.029854879,-0.06800923,-0.014052891,-0.010604331,0.019813022,0.071556754,-0.05621794,0.0052660317,0.017847423,0.09192907,-0.003748742,0.058407646,0.004991159,0.008374571,-0.016162522,0.14403878,0.009002053,0.037368163,0.014545556,0.004760622,-0.054728568,0.03365358,0.025604853,0.0020528138,0.117742725,0.088339806,-0.025508957,-0.05306735,-0.07573684,-0.029190041,0.03472029,0.004744972,0.058954958,-0.064051725,-0.08760111,0.077662654,0.04492311,0.0047933245,0.029507108,-0.057880472,0.02092701,-0.055523235,-0.05542321,0.03591836,0.003655933,0.033969186,-0.011548871,0.017585637,-0.07031595,-0.0044086347,0.09418523,-0.06456691,0.01895828,0.025171282,-0.087119356,-0.088947654,-0.053749755,-0.06129156,-0.0269274,0.08160937,0.029641561,0.018624505,0.022522857,0.06573063,-0.015985316,-0.033040185,-0.05430755,0.027794655,-0.0596421,0.017162532,-0.019986985,-0.13225587,-0.010071035,0.043916225,0.0034997507,0.009544849,0.0751223,0.025760563,-0.022382881,0.008596818,0.032882214,-0.03626536,0.043216918,-0.095547274,0.06639269,0.022174073,0.008347249,-0.11058835,0.023588683,0.01112505,-0.033104684,0.013849664,-0.0041495543,0.018454555,0.00012098159,0.071355745,0.001112323,0.011356627,0.0038339712,-0.0115880435,0.023603687,-0.042380285,-0.0025276705,-0.03367885,-9.2747325e-35,-0.031885516,-0.040295538,0.080545515,0.02361368,-0.02243572,0.0040130136,-0.04823848,-0.027812323,0.031482548,-0.14313574,-0.07956195,-0.0948183,-0.05986553,-0.020890575,-0.049360145,0.07583799,-0.09549178,0.024611115,-0.0343899,0.055202477,-0.052411593,0.11835485,0.014579803,-0.07813858,0.06266681,0.075846694,0.079057634,-0.04206494,-0.00018339926,0.019286275,0.020977685,0.06545666,-0.061487988,-0.013121753,-0.018718174,0.011510559,0.03759773,-0.06842898,-0.06358498,0.04115292,0.021975268,0.030187035,-0.020729983,0.0040581557,0.063463405,-0.017237201,0.04269773,0.024848135,0.008885699,0.037738122,0.0023177206,0.010047392,0.020890016,0.02927673,-0.025790423,0.03016866,-0.021052504,0.004296212,0.10683577,0.07598427,0.1287547,0.039689686,-0.023470473,0.062298078,0.012247682,0.017585753,-0.11558952,0.010882802,0.0011051327,0.06445792,-0.04627788,-0.041462213,0.045001127,0.023731625,0.011375831,-0.04446999,-0.037596717,0.01403408,-0.089252494,-0.014970519,0.011190222,0.010363983,0.024838278,0.048187077,0.032013744,-0.039915115,-0.020007685,-0.0312852,-0.0793802,0.022430563,0.0074143386,-0.004179914,0.0033164765,0.014631358,-0.07738211,-1.3824944e-33,0.060098253,-0.06133947,0.0089165745,-0.0011088832,-0.024673576,0.025944058,0.07037702,0.013861439,0.031068284,-0.022227677,0.01801841,-0.005584794,0.09493418,-0.058501966,0.013795522,0.05506512,0.044662673,0.08668433,-0.051141046,-0.018799499,-0.07204813,-0.0001931885,-0.05131043,0.046108466,-0.012084989,0.007715276,-0.007631827,0.037386466,-0.04301437,-0.08647051,-0.05430846,-0.05336383,-0.10010695,-0.0012907762,-0.04663874,-0.010756952,-0.053189397,-0.036152106,-0.009071848,-0.006376942,0.0024346379,0.077261075,-0.02519145,0.14958058,0.0037639998,0.020200877,0.033542585,-0.015961401,0.01183422,-0.032366294,0.030296829,-0.07440883,0.047369264,0.014377811,0.053912506,-0.06746117,0.032282285,-0.043580078,-0.025782967,0.05240878,0.022667777,0.018254915,-0.075605854,0.06924562,0.06157647,0.045347027,-0.11875951,0.07766159,0.057749186,0.02453008,0.05611907,-0.04703397,-0.022245148,-0.03821087,-0.028901227,0.12027935,-0.06311246,-0.055714462,0.020412497,-0.010278816,-0.06943839,-0.090910815,-0.038575746,0.041665863,-0.021449089,-0.10070207,0.029072443,-0.06037945,0.07982874,0.054247458,-0.014499632,0.019214436,0.0457612,0.036908183,0.04698078,-1.9540181e-08,0.09020645,-0.04896068,0.038053844,-0.013763972,0.01591666,-0.02937425,0.006865438,-0.009225498,-0.028885342,0.068874285,-0.0026693747,0.05192867,0.028383134,0.045001663,-0.0011161856,0.028709767,0.022472575,0.053433936,-0.021383705,0.02323319,-0.08806115,-0.008467956,0.016134027,-0.004524306,-0.013253651,-0.041514322,0.061336685,0.06451067,-0.0129375355,-0.0066434275,-0.020580621,-0.011991502,-0.06623447,-0.028101342,0.07906691,0.062387776,-0.02126734,-0.00714905,-0.013378596,-0.08336447,0.0700806,-0.059244815,-0.050779976,-0.040160317,0.04134963,0.024134416,-0.04891663,0.050710216,-0.08314832,0.019060422,-0.009406005,0.07250516,-0.01912255,-0.025959933,-0.10743034,-0.021193668,-0.013550455,-0.09041659,-0.01981534,-0.053063117,0.06682408,0.04974426,0.14930646,0.040356174 +3.4.22.71,In peptidase family C60. ,384,1.0,-0.014170749,0.028901746,-0.12933397,-0.01688262,-0.0522501,0.07942785,-0.032643378,0.08072242,0.020335067,0.044748712,0.11446201,-0.052556235,0.006880333,0.0141410455,-0.038834654,-0.030146698,-0.098085426,-0.022937905,-0.045479182,-0.057575677,-0.038645968,0.003074204,0.052817337,0.029854879,-0.06800923,-0.014052891,-0.010604331,0.019813022,0.071556754,-0.05621794,0.0052660317,0.017847423,0.09192907,-0.003748742,0.058407646,0.004991159,0.008374571,-0.016162522,0.14403878,0.009002053,0.037368163,0.014545556,0.004760622,-0.054728568,0.03365358,0.025604853,0.0020528138,0.117742725,0.088339806,-0.025508957,-0.05306735,-0.07573684,-0.029190041,0.03472029,0.004744972,0.058954958,-0.064051725,-0.08760111,0.077662654,0.04492311,0.0047933245,0.029507108,-0.057880472,0.02092701,-0.055523235,-0.05542321,0.03591836,0.003655933,0.033969186,-0.011548871,0.017585637,-0.07031595,-0.0044086347,0.09418523,-0.06456691,0.01895828,0.025171282,-0.087119356,-0.088947654,-0.053749755,-0.06129156,-0.0269274,0.08160937,0.029641561,0.018624505,0.022522857,0.06573063,-0.015985316,-0.033040185,-0.05430755,0.027794655,-0.0596421,0.017162532,-0.019986985,-0.13225587,-0.010071035,0.043916225,0.0034997507,0.009544849,0.0751223,0.025760563,-0.022382881,0.008596818,0.032882214,-0.03626536,0.043216918,-0.095547274,0.06639269,0.022174073,0.008347249,-0.11058835,0.023588683,0.01112505,-0.033104684,0.013849664,-0.0041495543,0.018454555,0.00012098159,0.071355745,0.001112323,0.011356627,0.0038339712,-0.0115880435,0.023603687,-0.042380285,-0.0025276705,-0.03367885,-9.2747325e-35,-0.031885516,-0.040295538,0.080545515,0.02361368,-0.02243572,0.0040130136,-0.04823848,-0.027812323,0.031482548,-0.14313574,-0.07956195,-0.0948183,-0.05986553,-0.020890575,-0.049360145,0.07583799,-0.09549178,0.024611115,-0.0343899,0.055202477,-0.052411593,0.11835485,0.014579803,-0.07813858,0.06266681,0.075846694,0.079057634,-0.04206494,-0.00018339926,0.019286275,0.020977685,0.06545666,-0.061487988,-0.013121753,-0.018718174,0.011510559,0.03759773,-0.06842898,-0.06358498,0.04115292,0.021975268,0.030187035,-0.020729983,0.0040581557,0.063463405,-0.017237201,0.04269773,0.024848135,0.008885699,0.037738122,0.0023177206,0.010047392,0.020890016,0.02927673,-0.025790423,0.03016866,-0.021052504,0.004296212,0.10683577,0.07598427,0.1287547,0.039689686,-0.023470473,0.062298078,0.012247682,0.017585753,-0.11558952,0.010882802,0.0011051327,0.06445792,-0.04627788,-0.041462213,0.045001127,0.023731625,0.011375831,-0.04446999,-0.037596717,0.01403408,-0.089252494,-0.014970519,0.011190222,0.010363983,0.024838278,0.048187077,0.032013744,-0.039915115,-0.020007685,-0.0312852,-0.0793802,0.022430563,0.0074143386,-0.004179914,0.0033164765,0.014631358,-0.07738211,-1.3824944e-33,0.060098253,-0.06133947,0.0089165745,-0.0011088832,-0.024673576,0.025944058,0.07037702,0.013861439,0.031068284,-0.022227677,0.01801841,-0.005584794,0.09493418,-0.058501966,0.013795522,0.05506512,0.044662673,0.08668433,-0.051141046,-0.018799499,-0.07204813,-0.0001931885,-0.05131043,0.046108466,-0.012084989,0.007715276,-0.007631827,0.037386466,-0.04301437,-0.08647051,-0.05430846,-0.05336383,-0.10010695,-0.0012907762,-0.04663874,-0.010756952,-0.053189397,-0.036152106,-0.009071848,-0.006376942,0.0024346379,0.077261075,-0.02519145,0.14958058,0.0037639998,0.020200877,0.033542585,-0.015961401,0.01183422,-0.032366294,0.030296829,-0.07440883,0.047369264,0.014377811,0.053912506,-0.06746117,0.032282285,-0.043580078,-0.025782967,0.05240878,0.022667777,0.018254915,-0.075605854,0.06924562,0.06157647,0.045347027,-0.11875951,0.07766159,0.057749186,0.02453008,0.05611907,-0.04703397,-0.022245148,-0.03821087,-0.028901227,0.12027935,-0.06311246,-0.055714462,0.020412497,-0.010278816,-0.06943839,-0.090910815,-0.038575746,0.041665863,-0.021449089,-0.10070207,0.029072443,-0.06037945,0.07982874,0.054247458,-0.014499632,0.019214436,0.0457612,0.036908183,0.04698078,-1.9540181e-08,0.09020645,-0.04896068,0.038053844,-0.013763972,0.01591666,-0.02937425,0.006865438,-0.009225498,-0.028885342,0.068874285,-0.0026693747,0.05192867,0.028383134,0.045001663,-0.0011161856,0.028709767,0.022472575,0.053433936,-0.021383705,0.02323319,-0.08806115,-0.008467956,0.016134027,-0.004524306,-0.013253651,-0.041514322,0.061336685,0.06451067,-0.0129375355,-0.0066434275,-0.020580621,-0.011991502,-0.06623447,-0.028101342,0.07906691,0.062387776,-0.02126734,-0.00714905,-0.013378596,-0.08336447,0.0700806,-0.059244815,-0.050779976,-0.040160317,0.04134963,0.024134416,-0.04891663,0.050710216,-0.08314832,0.019060422,-0.009406005,0.07250516,-0.01912255,-0.025959933,-0.10743034,-0.021193668,-0.013550455,-0.09041659,-0.01981534,-0.053063117,0.06682408,0.04974426,0.14930646,0.040356174 +3.4.23.50,In peptidase family A2.,384,1.0,-0.007852544,-0.017908309,-0.08127968,-0.049200032,-0.044173382,0.04811992,-0.0010268753,0.035447735,0.06749287,0.030035662,0.13741334,-0.03256781,0.0029068536,-0.012213107,-0.024288362,0.026688578,-0.06580159,-0.016109787,-0.03759917,-0.11203745,0.028967,0.033680886,0.045931213,0.028635858,-0.084412605,-0.0006129739,-0.018275622,-0.0004199279,0.05725953,-0.090241365,-0.015479173,-0.009942297,0.07837751,-0.027068792,0.046371657,-0.024008323,0.036463987,0.011039394,0.14134677,0.041749064,0.06372695,0.0078848945,-0.009229129,-0.08473885,0.014389113,0.026553234,-0.010853585,0.12043927,0.07749769,0.0028623028,-0.067523,-0.09133331,-0.05431585,0.009823546,0.02670986,0.08216582,-0.080503814,-0.029158464,0.052401062,0.055257127,0.027296068,0.0563271,-0.051635392,0.007733217,-0.02069893,-0.012937454,0.05876496,-0.04101921,-0.043910995,0.042671956,0.020496858,-0.050130468,-0.0016125737,0.07618182,-0.063139684,0.008591548,0.0030995284,-0.061774723,-0.09804063,-0.0459826,-0.077196546,-0.008459126,0.07126057,0.04983544,0.020166963,-0.00314662,0.042917192,-0.03785959,-0.057783168,-0.026907135,0.013608724,-0.118032455,0.08759332,0.04159183,-0.08183755,-0.00029838627,0.06016416,-0.06334384,0.001353406,0.046751987,0.011239096,-0.023699997,-0.038726933,0.014069818,-0.08278311,0.037026636,-0.07898429,0.0015914725,0.06148062,0.018694812,-0.054694064,-0.02218562,0.013364945,-0.021883931,-0.026782269,0.0035763236,0.03671299,-0.007509502,0.03549872,-0.006116596,0.036345303,0.017950542,0.029990604,0.05324412,-0.010045271,0.008227839,-0.08933636,-9.905738e-34,-0.009347902,-0.030815026,0.06769294,0.060094994,-0.058302194,0.030616414,-0.06568387,-0.016546998,0.04891351,-0.09620429,-0.07883348,-0.04899519,-0.05033891,-0.00908836,-0.069812305,0.08030424,-0.042404383,0.0016641638,-0.021859357,0.07212882,-0.06485321,0.119173884,-0.02003692,-0.07813293,0.053689927,0.039905664,0.08081308,-0.06856757,0.01792676,0.045083527,-0.009746695,-0.00049426017,-0.08052189,0.0012541134,-0.06157079,0.0027503758,0.04875818,-0.054693725,-0.029051669,0.052184638,-0.032021903,0.038628243,-0.004051259,-0.04602824,0.09851306,-0.043658424,0.028969646,0.0003749977,0.0070788087,0.070217215,-0.001346464,-0.020066835,0.08290629,0.041925073,-0.0748798,-0.006363516,-0.027622135,0.047455706,0.06259203,0.09192215,0.11644515,0.01780191,-0.05448562,0.044881772,-0.06173277,0.03250254,-0.09193123,-0.024132304,0.05629,0.06717397,-0.018893175,-0.03983308,0.08216035,0.048142824,0.029223517,-0.07545544,-0.0062215985,0.064675644,-0.05713042,0.02438694,-0.035654243,0.0019569607,0.044804323,0.018310426,-0.010370811,-0.031808455,0.008737509,-0.01742752,-0.058046293,0.0014514418,0.004848544,0.019669123,0.0033831496,-0.0024543616,-0.031369872,-4.121135e-34,0.0738517,-0.036451146,0.012101246,-0.026001278,-0.050158918,0.005768207,0.05865062,0.042495206,0.047142852,-0.019453902,0.017249849,-0.0015397393,0.061147228,-0.097819105,0.046986762,0.04188178,0.024248827,0.053374674,-0.0417834,-0.03398991,-0.05416866,0.015357538,0.0076244418,0.019260185,0.029637186,-0.0006007549,-0.047130194,0.05551031,-0.05407167,-0.0678359,-0.026847724,-0.018759297,-0.092570506,-0.02843468,-0.03105001,-0.023159284,-0.042863708,-0.015138569,-0.06336385,0.0029290973,-0.02077375,0.10456835,0.06596197,0.15357602,0.014206001,0.055477437,0.024884546,-0.0049053007,0.03282567,-0.039815348,-0.0065289154,-0.05748468,0.054037668,0.017178763,0.07061669,-0.06838575,0.023681043,0.03003904,-0.0765152,0.05390751,0.039066944,0.017817423,-0.029213106,0.0651231,0.058432292,0.0016699864,-0.1276182,0.01461807,0.0988186,0.06352504,0.024980186,-0.039491367,-0.03027051,-0.0021214602,-0.018034983,0.09094326,-0.08443682,-0.091188386,-0.005202661,-0.046310864,-0.108463064,-0.058442302,-0.014057305,-0.0010737035,-0.036479134,-0.10824248,0.027636882,0.043045636,0.0551064,0.06484881,0.037753582,-0.022565397,0.041057006,0.035852443,0.05184263,-1.6660177e-08,0.07722234,-0.049760647,0.021898877,-0.025494713,-0.032859378,-0.03885867,-0.018763505,0.032077983,0.034079727,0.016957369,-0.035909005,0.082148224,0.0057151425,0.06683025,0.0053932345,0.07275534,0.012907949,0.051651716,-0.0142533975,0.017968595,-0.07502279,-0.0036135756,-0.051717956,-0.00528873,-0.036649138,-0.03868364,0.021383025,0.00071028987,0.0003266116,0.002818312,0.031961873,-0.0020139893,-0.022960087,-0.09723109,0.038763896,0.031006163,-0.001412381,0.027048785,0.013341865,-0.04383591,0.07059925,-0.076356634,-0.046934094,-0.0425785,0.053160127,-0.02857419,-0.035525028,0.02649508,-0.05001055,-0.03569678,0.014913251,0.030812819,-0.012673112,-0.04133025,-0.10375096,-0.013935862,-0.019138694,-0.06407496,0.022082472,-0.08662762,0.07756107,0.07159037,0.1437404,0.05463769 +3.4.23.51,The reaction requires nickel to be bound to the precursor of the large subunit of hydrogenase 3. The endopeptidase uses the metal in the large subunit of [NiFe]-hydrogenases as a recognition motif [1]. In peptidase family A31.,384,1.0,-0.03422258,-0.03142035,-0.06211006,-0.0454322,0.11193581,0.041198276,0.0011095149,0.02278209,0.007788802,-0.014731946,0.022684261,-0.09810298,-0.096815936,0.013265997,-0.044195287,-0.049013946,-0.05377865,-0.03922813,0.012709659,-0.077661775,0.035580974,-0.0060541327,0.036675807,-0.05148783,-0.07998994,0.07454771,0.025567625,-0.13192019,0.011333151,-0.06308993,0.018969288,-0.114736825,0.04825721,-0.09729408,0.060557894,0.018769104,-0.031251375,0.00671191,-0.054630715,-0.04111148,0.09068197,-0.020206528,-0.0070906323,-0.00051207317,0.045622986,0.008817005,0.08352127,0.049637597,0.020724123,0.001735581,0.012956712,-0.0858555,0.022478504,-0.0149708865,0.0049255416,0.051144093,-0.014539167,-0.023596928,0.040186655,0.01206553,0.07044698,-0.006017114,-0.011784785,-0.0783953,0.08527365,-0.041718632,0.068824895,-0.101565436,-0.026532901,-0.007147122,0.013521539,-0.03758766,-0.11187944,-0.00054874184,0.010843048,0.078067444,0.03830103,-0.043714426,-3.734402e-06,-0.046805218,-0.0108835315,0.035830725,0.1253009,0.028294265,0.01677476,0.062083434,-0.0048763305,0.023245111,-0.03830855,-0.005301691,0.012953609,-0.0770381,-0.067163885,2.7249196e-05,-0.039792903,0.07359284,-0.045529716,0.04169692,0.0060634455,-0.0064020148,0.060077373,0.030467963,-0.03672071,-0.070106335,-0.038441174,0.085852884,-0.047357246,0.08695246,0.08144186,0.036219563,0.032799903,-0.036351364,0.027007146,0.005737475,0.033304997,-0.014272619,0.0036951657,-0.014119874,-0.031971194,0.038807984,0.053328134,0.025631279,-0.029198833,0.055350415,-0.053494755,0.104483694,-0.096328616,5.5730913e-34,0.020510318,0.016304342,0.00822754,-0.03321949,-0.025675587,0.02943824,-0.06625599,0.019074567,0.00095533044,-0.022293696,-0.013107179,-0.08577212,0.028219517,-0.07969149,-0.09803851,-0.010191476,-0.033148553,0.01925919,0.0037377197,-0.019956116,-0.022957087,0.058544822,-0.05964899,0.008095237,0.052739736,0.08285793,-0.009172332,-0.051338263,0.13387439,-0.026313547,0.03287141,-0.07488257,-0.033696562,0.009020304,0.06190753,-0.03348808,0.14565766,-0.04813553,-0.022474445,-0.04316069,-0.03197728,0.05455942,-0.045933828,0.034762863,0.070061795,-0.08544701,0.028659934,0.070560075,-0.010355304,-0.008895408,-0.00068711204,-0.039598886,0.08408115,-0.035591055,-0.04077866,0.05825585,-0.012119451,0.06293802,0.12817924,-0.028752198,-0.0023308937,0.10290542,-0.0029638808,0.029549314,0.014898057,0.05963324,-0.028699161,-0.011939151,0.015207856,0.0958835,-0.09018318,0.016370066,0.038571436,0.043843593,0.022117045,-0.087077245,-0.063530065,-0.052359935,0.08146869,0.0045791003,0.06934226,0.032014076,0.018737469,-0.014439491,-0.009609771,-0.065426484,-0.08773834,-0.061461437,-0.05027035,0.055080287,0.051728867,0.0010494723,-0.0036155754,0.04273271,-0.075263985,-2.8682184e-34,0.03665714,-0.041113287,-0.022345537,-0.07287132,-0.03656147,0.0302485,-0.027079795,-0.03928849,0.026388885,-0.044283286,0.114262335,-0.08402771,0.046383087,-0.039274186,-0.010016127,0.014844304,-0.0010235702,0.10905856,0.046402264,-0.04722943,-0.013425207,0.014805472,-0.013504237,0.068567604,0.044898756,0.039307028,-0.050894484,0.041412134,0.06874869,-0.00080585445,0.02198684,-0.026503505,-0.01362744,-0.050773565,-0.03149555,0.026743362,-0.035684247,0.010707533,0.05627501,0.010662792,0.010590161,-0.009164294,0.066425286,0.13036004,-0.005989546,0.046460442,-0.09435663,0.06259926,-0.01744723,-0.045393325,0.014279614,-0.038799707,-0.084223464,0.0061915917,0.010184849,-0.008294611,0.08620122,0.026802218,-0.014573017,0.004692048,-0.023656806,-0.01744205,0.096422024,0.042230573,0.063379854,0.0010909501,-0.051045645,0.12354981,0.07727481,-0.012320917,0.030081196,0.041410167,0.07720747,-0.012680758,-0.018647205,0.014656864,0.018608792,-0.04074197,0.070454076,-0.056376785,-0.051493026,0.050824355,0.009229809,-0.039602663,0.05079441,-0.057596274,0.02970174,0.12295626,-0.033617686,0.029751504,-0.02733268,-0.03053074,0.002572206,0.07681359,-0.018211504,-3.0579148e-08,0.03952042,-0.03288242,0.10130658,-0.08018162,-0.016442824,0.06794666,0.058492616,-0.014879717,0.009599096,-0.031515766,0.03590736,-0.0032322186,-0.022249369,-0.012428402,0.04478427,0.03323378,0.03532563,-0.0012057343,-0.017134925,0.0075420723,-0.053677887,0.022160953,-0.067234814,-0.058445223,-0.0062099397,-0.06861649,0.030773707,0.047554426,-0.074998036,-0.04357166,-0.042356223,0.0171997,-0.0692538,0.03452272,-0.018173838,0.051286053,-0.008222689,0.058605913,-0.015588088,-0.06440126,-0.06767882,-0.0031798275,-0.052539304,-0.021695742,-0.045399483,-0.052045714,0.04211675,0.032945182,-0.053403538,-0.009736801,-0.01507474,-0.09128814,0.009094821,-0.052837443,-0.07356309,0.02903636,0.014668017,-0.066877864,-0.026745811,-0.031933807,0.020629786,0.008933263,0.10311291,0.0761379 +3.4.24.87,In peptidase family M12. ,384,1.0,-0.027883988,-0.011179465,-0.08308217,-0.0514427,-0.009959529,0.008662187,-0.028925337,0.049041122,0.020312615,0.015644912,0.1144341,-0.01353051,0.0032888087,0.01562357,-0.03537889,0.022567539,-0.055316377,-0.026574844,0.0036678656,-0.07184884,0.03576695,0.044472124,0.045574125,0.036528,-0.080733456,0.013551603,0.021972235,0.034721717,0.06012172,-0.094390735,0.0015600041,-0.0003257973,0.07764747,-0.04393891,0.07206846,0.001959831,0.027689299,-0.018113952,0.10068269,-0.010322018,0.084431246,0.010209697,0.024156304,-0.08175752,0.033425685,0.012673013,0.01085857,0.09040312,0.05722412,0.019941593,-0.05345231,-0.10039529,-0.04268973,0.050725553,0.033263717,0.042831812,-0.08468615,-0.049544316,0.031719532,0.050315484,0.021040387,0.050137885,-0.07434668,-0.026093746,-0.017743813,-0.02694409,0.07322524,-0.050382428,-0.008119543,0.037230704,0.0395435,-0.061353657,-0.029801084,0.074242525,-0.06852524,0.032606635,0.015209169,-0.058792375,-0.07749735,-0.033999544,-0.068265155,0.0034376397,0.095484264,0.039196674,0.011728754,0.002219923,0.049000345,-0.016075972,-0.03258269,-0.03025059,0.023554906,-0.0839845,0.070459746,0.056550886,-0.079257786,0.0071166027,0.048542682,-0.014252946,0.007830757,0.056062177,0.035175197,0.0022315364,-0.04601351,0.012472745,-0.07941353,0.050891496,-0.08550408,0.036821194,0.062243387,0.008595737,-0.049286086,0.0032900707,0.039931238,-0.022445472,-0.0043190513,-0.013200935,0.030296458,0.00027497017,0.052041855,0.026480375,0.032907795,0.02081846,-0.009227604,0.024087759,-0.038369708,0.04285157,-0.107326396,-3.471451e-35,0.03009367,-0.035525292,0.06978059,0.06346714,-0.057349753,0.014057271,-0.06259813,-0.041473914,0.038535103,-0.12683573,-0.09235949,-0.098330535,-0.042208903,-0.027895927,-0.08430858,0.03821436,-0.044671293,0.016434701,-0.0021025753,0.058289785,-0.09741353,0.13624091,-0.008312909,-0.09395051,0.082650185,0.0997896,0.07991637,-0.06109769,0.036865037,0.04708524,0.0023482696,-0.015975773,-0.11753796,-0.00967126,-0.06334056,0.00927706,0.03129084,-0.09312387,-0.032646682,0.03551758,0.0038147527,0.052130274,-0.018349841,-0.015188607,0.07198962,-0.045340165,0.02292993,0.036676597,0.016900323,0.019515425,-0.009517073,-0.0031938376,0.036549248,0.033192668,-0.06769664,0.021590112,0.00043181432,0.010294405,0.09536353,0.047722716,0.106971115,0.039415214,0.00511106,0.06804274,-0.010787337,0.029486625,-0.11156053,-0.018734843,0.017509898,0.07984258,-0.021910507,-0.031483214,0.065632746,0.05947291,0.04435368,-0.10966936,0.014844136,0.05474059,-0.059202574,0.043473873,-0.012353849,0.0074957134,0.017568735,0.02020151,-0.035340846,-0.046007216,0.02564261,-0.05664244,-0.051624738,0.021837339,-0.017122542,0.0069537163,0.0008613618,0.014576466,-0.07379659,-8.117951e-34,0.06988861,-0.03533726,0.06417912,-0.009025227,-0.05760999,-0.0046626762,0.039955635,0.05799794,0.02121318,-0.004131948,0.037710465,-0.0007421716,0.055322755,-0.07811129,0.05497899,0.0106505025,0.05000928,0.057161134,-0.02927101,-0.04428663,-0.020353748,0.007259148,0.0065924143,0.03199703,0.002902891,-0.0036256837,-0.016606167,0.026711695,-0.042876422,-0.061947953,-0.025029892,0.0043426817,-0.10213794,0.002010541,-0.08081127,-0.010407259,-0.04761631,-0.024672383,-0.051999733,-0.020392483,-0.005700862,0.10547124,0.051148057,0.1568267,-0.029158082,0.03508666,0.06021713,0.0029640659,0.04564317,-0.06256357,-0.021652829,-0.034002066,0.025948605,0.008618792,0.07918672,-0.077829346,0.013427943,0.01835894,-0.031006338,0.07180509,0.045620885,0.01537208,-0.064594865,0.051319536,0.053221628,0.028257504,-0.1377509,0.011100599,0.076473325,0.06809778,0.035685774,-0.047575336,0.026452368,0.007229996,-0.018820085,0.09904407,-0.102965884,-0.074521735,0.009128922,-0.07822537,-0.028535593,-0.07663535,-0.041673645,0.02660591,-0.027675468,-0.13122402,0.042993292,0.042983584,0.0325542,0.034508582,-0.011778882,-0.019309144,0.016852552,0.0380039,0.019828368,-1.8103638e-08,0.074721225,-0.0740788,0.043460086,-0.024166344,-0.05327908,0.0011161251,-0.035974253,0.030000627,0.03842439,0.031052016,0.0046479832,0.045631073,0.007891344,0.040227897,0.0005225367,0.07838831,0.024824908,0.010286261,-0.024341134,0.022172749,-0.084473155,0.013040917,-0.013510076,-0.006148206,-0.022459865,-0.037451737,0.039585054,0.06655383,-0.016035866,-0.03639951,-0.0012299382,-0.006887798,-0.03651026,-0.049891453,0.007580559,0.039572395,-0.034974277,0.031002106,0.043204557,-0.082710706,0.06405937,-0.07353757,-0.04576964,-0.029716456,-0.002087277,0.0022499126,-0.040626522,0.024850618,-0.08717167,-0.042385176,0.00047509323,0.027442891,0.020546654,-0.04801958,-0.12661599,0.005830349,0.0014252564,-0.061798546,0.0061613102,-0.10302622,0.08489457,0.029747248,0.13065842,0.044704277 +3.4.25.2,The HslU subunit of the HslU---HslV complex functions as an ATP dependent 'unfoldase'. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolysed by HslV [5]. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis [7]. In peptidase family T1.,384,1.0,-0.11419844,-0.033445034,-0.0057638367,-0.022934128,0.051365405,0.019294484,-0.08315549,0.009534826,0.06448249,-0.0068097045,0.026176281,0.026567806,-0.016778765,0.05748084,-0.01949016,-0.082258426,-0.13171403,0.027511887,-0.070098415,-0.11685168,0.07273787,0.05274724,-0.046290506,0.023550786,0.011879718,0.053011168,0.04647587,-0.010368955,0.021723071,-0.03396866,-0.019003,-0.076308124,0.080384165,-0.0110652,0.043521933,0.11547769,-0.07373927,-0.018116051,0.008026799,-0.029084064,0.09341722,-0.046860382,-0.022975525,-0.0021468927,-0.013132723,-0.051873434,0.018166022,0.011543685,0.04668493,0.005633565,0.045202278,-0.016480811,0.004958229,-0.03497123,-0.058655243,0.11144173,-0.05526417,0.0016085452,0.043585762,0.0074817045,-0.009915885,0.043884374,-0.03139503,-0.006573953,0.021030292,-0.102321796,0.04823,-0.007567491,0.014946754,-0.0023245485,-0.07488582,-0.0018432426,-0.04045391,0.06588508,0.024435088,-0.015905125,-0.002577436,-0.06343863,-0.010264162,-0.00960886,0.030503575,-0.03196541,0.07707765,0.09484332,0.017606374,0.0002055378,0.00280852,0.0028914344,0.06486294,-0.034679182,-0.014318655,-0.10948664,-0.015640011,0.04374538,-0.03722429,0.036087625,0.038975496,0.0007467255,0.008967727,0.0032775584,0.029394582,0.015947334,0.027348323,-0.030645618,0.034477074,0.062461074,-0.067133844,0.08465976,0.03853986,-0.019649668,0.011592781,-0.026225861,0.060037427,-0.048369702,0.03212905,0.07616145,-0.036149777,-0.0016899265,-0.04586109,-0.04848388,-0.024061665,-0.035000976,0.094857,0.051229056,-0.111253284,-0.057491716,-0.060171377,7.2558022e-34,-0.05195051,-0.06944773,0.024108965,0.045602486,-0.059006084,-0.041485615,-0.056936815,-0.022474384,-0.028034233,-0.00072305364,-0.039451726,0.031262286,-0.030338421,0.0072015068,-0.11202862,-0.04409714,0.013337917,0.060361937,-0.034235295,0.039388623,-0.028322091,0.055843018,0.022144806,-0.10639108,0.056809686,0.017877402,-0.01355314,-0.054828543,0.0607653,0.01660102,-0.048590895,-0.058303405,-0.08587829,0.019260505,-0.0042417445,0.040488128,-0.007265745,-0.0346338,0.008724859,0.011444261,0.0054598427,-0.0022313404,-0.0016170024,-0.040769886,0.035447743,-0.00086159486,0.041129805,0.011134923,-0.12072431,-0.0040944517,0.018556435,-0.046124898,0.091160774,-0.022911688,-0.0996319,-0.0018490274,0.06998081,0.036900308,0.07807883,0.056441043,0.046552446,0.11367963,-0.13160059,0.0770474,0.0034797804,0.03495717,-0.029807342,-0.016411029,-0.0011758836,0.10720729,-0.08710416,0.11213314,0.048152655,-0.015163632,0.043396592,-0.018380342,-0.05110812,0.056461107,-0.025051616,0.120027125,0.0036124901,-0.029661644,0.0043209754,0.00943248,-0.034796923,-0.055281714,0.00875114,-0.09728294,-0.079228334,0.036324736,0.044764876,-0.005899612,0.07022412,0.038264595,0.04715846,-3.5929903e-33,0.06500209,-0.089456216,0.06756355,-0.06715015,-0.10376331,0.037338965,0.038131822,-0.042097222,-0.01624443,-0.032899726,0.008328847,-0.05033911,-0.09735791,-0.057650242,0.024562437,0.02277706,-0.018695604,0.06623182,-0.045278177,0.047858797,-0.037037484,0.060425088,0.059749275,0.080143824,-0.013122721,-0.05317202,0.078804724,0.021699939,0.04612269,0.0361828,-0.041677643,-0.017564889,0.0010566541,-0.011480756,-0.08993579,0.005023998,-0.06718212,0.0076310947,0.033605043,-0.07848051,0.08696555,0.07202889,-0.017046647,0.016313896,0.014273401,0.12432284,-0.016913949,0.08162404,-0.051814236,-0.06310168,0.01853745,-0.012215363,-0.03180305,0.03370486,0.042783286,0.02782458,0.009184628,0.034469064,0.02448869,-0.03422387,-0.05065356,-0.0028660884,-0.026310904,0.042065088,0.015902631,0.009616732,-0.060625713,0.0072068707,0.0052440097,0.0076636006,0.013793403,-0.068119556,0.03363737,-0.014297991,0.06297746,0.03430202,-0.075086564,-0.046688467,0.006971764,-0.0593346,-0.040389042,0.025865221,-0.100062,-0.0944804,0.0872505,-0.058695998,0.032856416,0.053230185,0.045356076,0.04522618,0.073143564,0.011617154,0.02882004,0.051309425,0.0023839136,-3.5600987e-08,0.0060949987,-0.031454403,0.059152868,-0.05536331,-0.025925266,0.038686704,0.0497155,0.025100037,0.10179937,0.045150407,-0.005149664,-0.0075254445,0.0028585545,-0.011960338,-0.019282458,0.09324139,-0.07581346,0.09454352,-0.0020474652,0.018785026,-0.02396501,-0.030644218,-0.043162048,0.054229338,0.014298713,-0.09843675,-0.014915544,0.019309547,0.0068124267,-0.15043016,-0.005285334,0.052246124,-0.084434055,0.030541655,0.021801107,0.048317727,-0.033090107,-0.022899091,-0.034275915,0.04653089,0.02049853,-0.041320894,-0.01835152,-0.03611505,-0.020269,0.059304435,0.0075539225,0.038549986,-0.01218442,-0.022126859,-0.0490136,0.0034853271,-0.042337228,-0.11379419,-0.067357145,0.045783427,0.015052811,-0.06520375,0.013287259,-0.063882984,0.030731054,0.011091369,0.091888435,-0.015087361 +3.5.1.99,"Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.",384,0.99999994,0.0018402765,-0.062324736,-0.06235051,0.066555575,-0.06656617,0.08335302,-0.0037201205,-0.0050654863,0.043928094,-0.028627124,0.007092227,-0.07412277,-0.094554745,0.057958484,0.010049883,0.008335159,0.007823945,-0.0103879105,-0.045580007,-0.053897824,0.044800017,0.019952003,0.011576311,-0.067419045,-0.03304737,0.051984895,0.054559186,-0.08267003,0.031773835,-0.008345023,0.011969617,-0.11808282,0.0007651753,-0.026985398,0.012466355,-0.0055852,-0.10573381,-0.08049788,0.08917262,-0.012425248,0.13497254,0.04145039,0.0067453957,-0.027247027,0.025055634,0.009868101,-0.037664272,-0.03299381,0.059260722,-0.054969735,0.001102516,-0.0778916,0.029697245,0.052432846,-0.019217996,-0.007818704,-0.019260615,0.003927309,-0.05025333,0.018799286,0.004472151,0.052617434,0.023007406,-0.016102245,0.039445188,-0.044503115,-0.024142867,-0.024674684,0.030241864,0.011029056,-0.037496112,-0.05504317,-0.0056927484,-0.037074976,-0.0014010606,-0.0013958575,0.0010595297,-0.008551624,-0.011056652,-0.08583305,0.09730693,0.019552274,-0.0040321364,0.08457525,0.08497019,0.05506111,0.027781505,0.010132839,0.0038355622,0.010064107,0.012811333,-0.06252863,-0.024445346,-0.028462538,-0.10472506,-0.08316559,0.013142729,0.010571215,-0.074830554,-0.0065230783,0.015387343,0.06896146,-0.052049246,-0.04521609,-0.0704101,0.04354088,-0.040659513,0.06193807,-0.011427283,-0.0025967602,0.01322566,-0.006310913,0.08523629,0.0659539,0.06045843,0.027493237,0.047487456,-0.039863314,0.027272815,-0.02909695,-0.069841266,-0.003224139,0.038999397,0.060154565,-0.006916065,-0.013185178,-0.0979716,1.0081657e-33,0.039049912,-0.087798186,-0.039981853,-0.030629253,0.019146916,-0.043214492,-0.05184455,-0.021147372,0.037275717,-0.09458419,-0.08327568,-0.049156472,0.010153227,0.0127870105,-0.011239108,-0.022108186,-0.029738363,0.049161464,0.12015317,-0.066731185,-0.055170875,0.0761203,0.055191334,-0.023626383,0.026076123,-0.004655664,-0.03583692,-0.045021433,0.038543545,-0.006714165,-0.05939049,-0.08936937,-0.10703497,0.06447771,-0.029537676,0.03456535,0.020555843,-0.03085885,-0.023970312,0.03461122,0.043355364,0.00273944,0.004648986,-0.03346403,-0.02399351,0.03032427,-0.029672092,0.1312251,0.05059563,-0.035177894,0.043085933,-0.07056361,0.10668686,0.0040141097,-0.10180309,-0.04678096,-0.028677408,-0.015230115,-0.013669977,0.07100959,0.044968434,-0.020191869,-0.078754835,0.057393014,0.030463915,0.009175071,-0.05969036,-0.06784594,0.05473037,0.08072851,-0.03108497,0.010327085,0.086960986,0.08974461,0.038782615,-0.06016278,-0.06713078,0.051541973,-0.02642719,0.1209906,0.07438888,-0.013709639,0.01890682,0.037134457,-0.007148132,0.0019326105,0.06984014,-0.014754487,-0.0073110755,-0.019765051,-0.019263657,-0.020642906,-0.014789601,0.066028796,0.02193782,-1.6515097e-33,0.058474123,-0.13881026,0.07479635,-0.03736979,-0.057902962,0.05943379,-0.023981877,0.019400703,0.02684462,-0.024884071,0.06764419,-0.011378915,0.104264766,0.021956153,0.04089121,-0.03382155,-0.16271509,0.020312373,0.03155603,-0.07653058,-0.056302022,0.00654349,-0.022323739,0.06670238,0.05744775,0.051809028,-0.04100286,0.06368389,-0.018464759,0.026837915,0.012349238,0.04448007,-0.08292306,-0.083823256,-0.059931237,0.10600413,0.00075846846,-0.041258615,-0.04785479,0.048471343,-0.026616776,0.05082169,0.04991716,0.045023113,0.025024084,0.014889431,-0.07154224,-0.005710112,-0.101642266,-0.03116883,0.046422582,-0.026848419,0.025673995,-0.017120281,0.00010586338,0.09714456,0.0114844,0.013043136,0.0018397907,-0.055901103,-0.038380783,-0.0039359233,0.00539706,-0.058378495,0.007130476,0.020481957,0.0581555,-0.0347365,0.0484707,-0.013116022,0.079564124,0.041181378,-0.0018143229,0.07415903,0.011203208,0.029141484,-0.021911757,0.0053286543,0.04193346,-0.029371813,-0.025407352,0.001032419,-0.019619556,-0.012679462,0.045192137,0.05370582,0.004829819,0.10652143,6.515132e-05,0.026190273,0.012374593,-0.02428285,-0.05266814,0.09593343,-0.016267443,-2.938165e-08,0.056214638,-0.06043529,-0.076513626,-0.024238897,-0.060168825,0.019898545,0.042604916,-0.020050459,-0.034646716,-0.040077932,0.0140725225,0.0014925752,-0.0481435,0.07868935,-0.040235125,0.020441713,-0.024241405,0.04359638,-0.019747494,-0.057180278,-0.026468867,-0.025302514,-0.05276251,-0.014072601,0.055846952,-0.0892125,-0.021897204,0.07781633,-0.038612884,0.021732494,0.028234284,-0.006131309,0.061567448,-0.04226105,0.07146314,0.06190794,0.0725205,-0.08541972,0.010617566,0.039789643,0.04416617,-0.0006723258,-0.0009402589,-0.0353567,0.06483871,0.017464796,-0.011431223,0.060123507,0.023761401,-0.00050868443,-0.028678533,0.05035451,0.022689402,-0.04265756,-0.124822415,-0.09476098,-0.06835045,-0.052788973,0.052082274,0.0011706826,0.050669473,0.075473845,0.16211793,-0.004134016 +3.5.1.100,"In addition (R)-piperidine-3-carboxamide is hydrolysed to (R)-piperidine-3-carboxylic acid and NH3, and (R)-N-tert-butylpiperazine-2-carboxamide is hydrolysed to (R)-piperazine-2-carboxylic acid and tert-butylamine with lower activity. The enzyme does not act on the other amide substrates which are hydrolysed by EC 3.5.1.4 (amidase).",384,1.0,0.05400236,-0.11482052,-0.07314904,-0.02300749,0.06751493,0.06048365,-0.08547411,0.04884342,0.017556246,-0.06248238,-0.04351397,0.008947367,-0.028842753,0.060370494,-0.02058428,-0.015448964,-0.029708715,6.6087596e-05,-0.036979746,-0.055361822,-0.01676782,0.03584303,0.07467574,-0.0043287347,0.031615175,0.070326276,0.060094584,0.0024826373,0.035153434,-0.06714112,0.01507231,-0.0143038025,0.046677295,-0.06045549,0.04020826,0.011704099,-0.04475846,-0.012563478,0.042461444,0.026937502,0.010978919,0.035498254,-0.013076048,-0.018391294,-0.0040911497,-0.08106617,-0.021344373,-0.020916507,0.028122483,-0.026381547,-0.007920794,-0.039241225,0.0140439,0.031492114,-0.08360196,0.005934997,-0.050419256,0.044821266,-0.09023807,0.033645567,-0.0138080865,0.048143163,0.05677093,-0.027369766,0.034563005,0.023304706,-0.050400015,-0.039202563,0.037823573,0.014985132,-0.12979595,-0.08985651,-0.017919471,-0.018503118,-0.00891646,-0.09737459,0.036022373,-0.009703696,0.027520321,-0.004501341,-0.017792605,-0.033931788,-0.060802527,0.012106297,0.013000335,0.046711247,-0.02347328,0.032160066,0.03851286,-0.017670926,0.020852877,-0.033421014,-0.0022287334,-0.011132077,-0.070851386,-0.051266976,-0.0007217766,0.031994116,-0.030986257,0.018319493,0.00977124,0.07779117,-0.12210498,-0.09294257,-0.05719946,0.023721753,0.0302436,0.073662326,0.03146048,-0.006700544,-0.029548183,-0.067528546,0.018885506,0.0148616815,-0.0683608,0.022165323,0.029017596,-0.05591133,-0.037603162,-0.04608014,0.06712718,-0.040480983,0.098896585,0.012229376,0.0061795474,0.0067068515,-0.09973394,2.8222029e-33,0.04194497,-0.012219328,-0.025210945,0.00081955595,-0.006291206,0.08190992,-0.055667266,0.06497252,-0.01825408,-0.0415952,-0.0075244997,-0.0054746186,0.054713164,-0.07248801,0.002525912,-0.042543426,-0.04137488,0.029014181,-0.023699151,-0.0061295005,0.0047866115,0.07983979,-0.058856394,0.07677535,-0.011165787,0.060258236,0.033440214,0.06807028,0.114766754,-0.039052896,0.015552443,-0.042094428,-0.105613604,0.050692905,0.027467418,0.014728273,-0.031364072,0.0015304299,0.0007461253,0.11813518,0.019388463,-0.00025434853,0.00630723,-0.10507414,0.01838992,-0.07797006,0.0056887935,0.122626096,0.037981667,0.010300819,0.02808866,-0.030767344,0.099609844,0.019928113,-0.0397983,0.06041215,-0.09738041,0.050704032,0.075479,0.024574537,-0.042180292,-0.06193423,-0.005354228,-0.025672393,-0.027490022,0.05651252,-0.10300772,0.007530252,0.05963758,0.13804665,-0.02917322,0.04658256,0.027346777,0.13956094,0.1012385,-0.05193084,-0.06317519,0.052447382,0.12008887,0.0146196885,-0.06156183,0.034170087,0.016551675,0.061436158,-0.02504319,-0.036129087,-0.033581853,0.0046801507,-0.0030136534,0.0995466,-0.047772016,-0.07222002,-0.01253451,0.03621675,0.066989645,-3.860668e-33,0.09581776,-0.011465496,-0.08549272,-0.014840043,-0.016350316,-0.010419865,0.028953886,-0.04442982,0.00016321533,-0.046643056,0.028330944,0.019720582,0.054790672,-0.019196121,0.044873837,-0.01713658,0.044485312,-0.020491231,-0.015297066,0.00519565,0.03898695,-0.009803572,-0.037873033,0.03761205,-0.015331884,0.027961418,0.033906396,0.02007191,0.08893352,0.042736813,0.027317397,0.009124267,-0.03627434,-0.10263827,-0.05452011,0.113643095,-0.01957632,-0.033950306,-0.10887267,-0.0009159728,0.020622473,0.020696757,0.005104584,0.07223765,0.04355723,0.037822857,-0.07928984,-0.0071248943,-0.01577583,-0.06806012,-0.002042294,-0.081592605,-0.020257961,-0.017632926,0.012896756,0.06206311,0.018459236,-0.045966186,0.036890112,-0.020388745,0.0006731119,-0.036037996,-0.0070820684,-0.040470425,-0.07290705,-0.09404251,-0.026703462,0.055663094,0.1104917,-0.051769238,0.058604058,-0.044897966,0.10212029,0.085232414,-0.05348949,-0.035900176,0.0010424474,-0.030284606,0.12215272,-0.09894577,0.032603305,-0.023269026,-0.034596033,-0.06384292,-0.025940232,-0.0032438578,0.022091182,0.09287703,-0.05034506,0.030497232,-0.0015882086,0.010327749,-0.03192499,0.09627863,0.012879784,-4.5978357e-08,0.10641936,-0.07491812,-0.0022664212,-0.0014192293,-0.009951318,0.041561462,0.0135142775,0.008087373,-0.028528446,-0.05738998,0.049468767,-0.032136064,-0.055307392,0.0074865636,0.056168966,0.051598832,-0.018456945,0.045858406,-0.06695107,0.03599075,-0.1302247,0.028947169,-0.08274125,-0.026452314,0.0137175685,-0.021112284,0.030544713,0.011405452,-0.027513493,-0.012291451,-0.021048905,0.058291767,0.09141644,0.0019120666,-0.056102645,-0.006575146,0.008675904,0.03867247,-0.06131106,0.021616,0.04670032,-0.057075348,-0.04282854,-0.0023279856,0.047230538,-0.042797733,0.0016209548,0.01736252,-0.025467679,-0.072162285,0.010450661,-0.04668717,0.020325352,-0.027344665,-0.019158805,0.040404018,-0.03160717,-0.09596658,-0.02371801,-0.01847071,-0.059515737,-0.0142209,0.164106,0.0032481365 +3.6.4.12,"DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. Some of them unwind duplex DNA with a 3' to 5' polarity [1,3,5,8], others show 5' to 3' polarity [10,11,12,13] or unwind DNA in both directions [14,15]. Some helicases unwind DNA as well as RNA [9,10]. May be identical with EC 3.6.4.13 (RNA helicase). ",384,1.0,-0.043062255,-0.015353879,-0.02344891,-0.03199129,-0.055432156,0.019219762,-0.05386472,-0.034760043,-0.046902593,0.0086720325,0.041812457,0.09741393,-0.08754501,0.0066401195,0.03367441,0.05026194,-0.08686039,0.057256218,-0.06052216,-0.044357073,0.12354731,0.01226369,-0.0041141626,-0.021871073,0.0021534052,0.11483486,0.018162029,0.0055792765,0.054707713,-0.108155705,0.029108873,-0.04228966,-0.079501614,-0.062594175,0.08390852,-0.006660407,-0.004906243,0.06513632,0.022997404,0.0429453,0.10704955,0.043527417,0.030189903,0.009154368,-0.11278472,-0.03168207,-0.039434675,0.06772848,0.062566616,-0.04304889,0.029348785,-0.042465344,0.017698213,-0.043887973,-0.019536462,0.07644406,-0.018840373,-0.030298745,0.013258732,-0.035140894,0.05021263,-0.022155808,-0.031082174,-0.0068568033,0.10953288,-0.021992633,0.09308377,-0.020295713,-0.0027985352,0.026252942,0.008748628,-0.03335624,-0.0033922975,0.04453686,0.033366993,-0.0028298127,0.017187169,-0.01881271,-0.021144109,0.07534721,-0.081502214,-0.10251329,-0.0140648885,0.051561642,0.006851849,0.043443214,0.050745767,0.038209114,-0.0044978196,0.07840563,-0.082647376,-0.05200663,0.008704961,-0.06326407,0.004774772,0.0073746005,0.009753793,0.08316514,-0.025961969,-0.0773683,0.11839966,0.026133263,-0.035649188,0.046332873,-0.013735377,0.031352717,-0.030268326,0.02849107,0.06357958,0.048586946,-0.033061553,0.029291095,0.008875739,-0.046866167,-0.054581054,0.030790173,-0.070944674,0.04827699,0.03317424,0.08185707,0.024641858,-0.06641232,0.056883227,0.087148465,-0.029011449,-0.057392165,-0.053461205,3.0700296e-34,-0.060325593,0.0164823,0.049743,0.0016693568,-0.020422522,0.029253386,-0.108479954,-0.0077481135,-0.08327578,-0.028077986,-0.0675398,0.09735183,0.06453162,0.020418692,-0.08455905,-0.086961865,0.018301772,0.0422002,-0.04225154,-0.012076737,0.025624042,0.010262883,0.0058526373,0.03800201,0.033595096,-0.060317416,-0.019291969,-0.009192138,0.044533774,0.005206194,-0.005444448,-0.04121383,-0.026463345,0.10443583,0.06049138,0.05779624,0.0003007861,-0.027780838,0.07328217,0.08831282,-0.026865378,-0.03137999,0.06424909,-0.068469614,0.06427155,-0.11497884,0.021216707,-0.017636903,-0.057821438,-0.045738533,0.06249735,-0.006173479,0.016752783,-0.041168552,0.054023303,-0.057935428,0.05327316,0.046601225,0.023041202,0.078553684,-0.008659651,0.076898456,-0.026178883,-0.030874101,0.02921936,0.039072085,-0.019019827,0.0037004456,0.0247305,0.04532175,-0.06750087,0.022029541,0.029909955,-0.007260144,0.005426026,0.050030313,-0.07522727,-0.009134052,0.03584107,0.10748219,-0.012252089,-0.025916126,-0.044091012,-0.0959404,-0.11420897,-0.016322708,-0.03170207,-0.08153969,-0.03316042,0.04862809,0.11973539,-0.00112244,0.010430475,-0.06380746,0.057875607,-3.872261e-33,-0.0074094804,-0.03290735,0.00073444645,0.0062159714,-0.045212496,0.0004791465,0.06631285,0.05617099,-0.03204467,-0.089866534,0.08744522,-0.04614227,-0.035547737,-0.08260132,0.015572191,0.045909826,0.01660376,0.058560725,0.058101423,0.034498315,-0.0027457634,0.07768306,-0.0009286356,0.08937033,0.022393307,-0.043440856,0.0110600935,-0.052402824,0.12296083,-0.015073905,-0.00040109482,-0.013517163,0.024898835,0.034485158,-0.055766955,0.053184424,-0.007217941,0.00538069,0.045405783,-0.04986961,-0.026005615,0.094471514,0.00042278762,0.026561847,0.00956012,0.10030081,-0.07305255,0.09771504,-0.047933266,-0.031515826,0.0030217618,0.004940098,-0.0533032,0.046497185,0.019023625,-0.07267911,-0.005519937,-0.0009775137,0.014855225,0.03658405,-0.012937879,-0.05099301,-0.04319663,-0.05209505,-0.053347133,-0.016174674,-0.0485679,-0.0019734865,-0.0760607,-0.011631777,-0.05558097,-0.020398615,-0.0046247425,-0.052739214,0.038937658,0.03698056,-0.018236924,-0.039867062,-0.042911474,-0.037993718,-0.086942025,0.038099077,-0.060916435,-0.06403108,0.0879201,-0.04972927,0.00657821,0.005100367,0.009099338,0.009017737,0.046781998,-0.00087546284,0.023705678,0.036524843,0.034919433,-3.9911207e-08,0.09156971,-0.078552194,0.11600741,-0.05829448,0.022622028,0.012220487,0.0048993686,0.04461457,0.104552366,-0.03992472,0.010097372,-0.0046732416,-0.0241025,-0.03194915,0.09267463,-0.011104952,-0.03470549,-0.037685577,0.048812177,-0.053066727,-0.056451544,-0.044425584,-0.10098626,0.059289154,-0.09094805,0.05353435,0.052826114,-0.018067062,-0.010340682,-0.051875874,-0.030292079,-0.029320838,-0.010934438,-0.04649806,-0.120495014,-0.0025502048,0.035671853,0.024922414,-0.024613066,0.024131985,0.056964044,-0.025371237,-0.0756672,0.008083964,-0.022897834,-0.013355664,0.031664632,0.029947177,-0.07364117,-0.059730764,-0.041406557,-0.035287905,0.0070461934,-0.09470572,-0.01820982,0.003339419,-0.042287577,-0.029262332,-0.08014531,0.008475911,0.015851516,-0.0028636248,0.074226886,-0.06776556 +3.6.4.13,"RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. Some of them unwind RNA with a 3' to 5' polarity [3], other show 5' to 3' polarity [8]. Some helicases unwind DNA as well as RNA [7,8]. May be identical with EC 3.6.4.12 (DNA helicase).",384,1.0,-0.013320964,-0.033810627,-0.0029029883,-0.021804595,-0.029240824,0.049290985,-0.054016706,-0.056560174,-0.0339055,0.040753968,-0.014476239,0.06522635,-0.087616175,0.011574831,0.03266076,0.061856624,-0.08670221,0.012153605,-0.06212275,-0.04346099,0.112996876,0.06110377,-0.017707106,-0.026405778,0.006553521,0.10288596,0.032947782,-0.0043398966,0.04549766,-0.097328864,-0.0053023645,-0.0488458,-0.0066154283,-0.050573613,0.050696872,0.016546946,-0.02739229,0.024805883,0.035111457,0.08841767,0.08387421,0.04041593,0.021611532,-0.02852979,-0.091246404,-0.017878488,-0.024188649,0.050731234,0.050526183,-0.029752389,0.03128696,-0.060059488,-0.013293468,-0.055562247,-0.01880717,0.08166646,0.021582223,-0.027113738,0.005937217,-0.0684687,0.041141734,-0.04016133,-0.026367662,-0.02062852,0.1061714,-0.029685644,0.08579643,0.0040881727,0.01350337,0.030352762,0.000368195,-0.007140989,-0.039624505,0.08359364,0.017105121,0.004449934,0.03876502,-0.023401784,-0.00173516,0.030933416,-0.074554004,-0.06990193,-0.00783051,0.045170028,0.005038305,0.087820254,0.033571385,0.040187705,-0.0008591733,0.07318087,-0.048778262,-0.053483844,0.025767392,-0.027025973,0.031606477,0.00650845,0.014845102,0.06302805,-0.031541776,-0.09366417,0.12074632,0.07032531,-0.06959617,0.02441727,0.001694776,0.06878125,0.016090112,0.018355818,0.042393472,0.08720662,-0.02862706,0.008280724,0.009062476,-0.07764939,-0.03820794,0.022588082,-0.056447,0.043977153,0.02101957,0.1073894,0.031318672,-0.060883746,0.042117056,0.098045535,-0.04758504,-0.03840208,-0.069757104,2.5810522e-34,-0.04156431,-0.031618007,0.025117166,-0.018359123,0.004209566,0.017174907,-0.10213842,0.0007556998,-0.06876329,-0.07443261,-0.09077725,0.0984212,0.04381622,-0.020967396,-0.06569992,-0.088559546,-0.0016481938,0.0476773,-0.055971112,-0.022328835,0.023951447,0.0159701,-0.0141215315,0.03980703,0.016038347,-0.06386509,-0.012185047,-0.025964255,0.021375801,-0.003382669,-0.028580805,-0.044073172,-0.047408078,0.09247375,0.050860282,0.008601536,-0.008828832,-0.021254245,0.062243916,0.079897776,-0.00065780437,-0.018547771,0.046574604,-0.032921772,0.046907704,-0.09567728,0.0023466935,-0.0072689494,-0.04529151,-0.046078824,0.11429245,-0.013376271,0.026046632,-0.06664456,0.061389085,-0.06369799,0.041524284,0.055172842,0.0357895,0.06212873,-0.020897912,0.07585917,0.015380968,0.019266272,0.015631264,0.044767756,-0.052038163,-0.041048672,0.022498626,0.06232703,-0.06442023,0.030064331,0.06878931,-0.018039543,-0.03715611,0.043268908,-0.07169446,-0.011172992,0.01222327,0.12186429,-0.0030433321,-0.044280127,-0.055898316,-0.093697734,-0.11123435,-0.018560022,0.016539784,-0.106779926,-0.04430064,0.0692624,0.10308331,-0.005907544,-0.013795745,-0.049304634,0.04374418,-3.7486757e-33,-0.023896165,-0.018871166,-0.009710116,0.0010525278,-0.07163416,0.027347201,0.059175268,0.014212765,-0.04647667,-0.07517114,0.05743107,-0.017452428,-0.018219134,-0.08821676,0.013961643,0.024945952,0.0075535784,0.041333705,0.034405477,0.028478244,0.0036732862,0.07420435,-0.011950729,0.07095335,0.02166478,-0.044219125,0.0035891011,-0.023083663,0.09710055,-0.015342965,0.025245478,-0.025383562,0.012952478,0.027826505,-0.071041375,0.034617342,-0.013867762,0.0016727505,0.0520053,-0.03716168,-0.020143598,0.08612581,0.013289122,0.037949007,-0.0077411756,0.09021116,-0.06745561,0.07439705,-0.029186593,-0.03795208,0.018196702,-0.0233098,-0.018465398,0.083876975,0.023988105,-0.07432092,-0.023714915,0.023229584,0.011736217,0.032395706,-0.033792388,-0.047076367,-0.027682288,-0.04683296,-0.03406611,-0.017180784,-0.027449867,0.015553285,-0.0605767,-0.05324906,-0.02206582,-0.041804455,0.017060192,-0.033861894,0.055304267,0.03177775,-0.020827431,-0.033646908,-0.09935792,-0.026431581,-0.112029195,0.05218341,-0.05258794,-0.0617612,0.06878523,-0.062317975,0.03999606,0.029660953,0.006944057,0.048659317,0.05804856,-0.015231718,0.031897407,0.022584619,0.04348104,-3.354324e-08,0.059669744,-0.06330082,0.13865095,-0.042142503,0.04296554,0.020166691,-0.00012900081,0.07019568,0.112386994,-0.011740714,0.026995057,-0.055566207,-0.022524377,-0.023304503,0.11153905,-0.014594831,-0.061453015,-0.0197512,0.05043078,-0.048259653,-0.069821596,-0.022783184,-0.10517509,0.04765372,-0.11656891,0.041143544,0.067557156,-0.029043473,-0.0014014285,-0.067970954,-0.032596257,-0.001268034,0.041379645,-0.08010405,-0.14907193,0.008094317,0.075765304,0.03227531,-0.036374427,0.042307116,0.039418805,-0.0316723,-0.07684374,-0.012123236,-0.05726956,-0.025761986,0.02633502,0.055749547,-0.042118255,-0.06631008,-0.0034009314,0.0002467158,-0.0013871803,-0.07477896,-0.018859787,-0.0037803403,-0.08470438,-0.028791707,-0.05769215,0.02160685,0.0064383945,-0.020183226,0.09372201,-0.051195234 +3.7.1.11,"Highly specific; does not act on cyclohexanone or cyclohexane-1,3-dione as substrate.",384,1.0,-0.024782049,-0.049235985,-0.03810174,-0.028593,0.03955262,-0.008907135,0.035496227,0.001253835,0.02276228,-0.073374316,0.036716864,-0.05100818,-0.07659077,0.124357454,-0.011964883,0.017314686,0.008088398,-0.0010042564,0.07815887,0.017967658,0.06277928,-0.04922984,0.06406731,0.0214411,-0.025472853,-0.028526409,-0.008052462,0.07396416,0.013667569,-0.017643739,-0.035021193,0.04999854,0.04370221,0.005585289,0.051336035,0.04677879,-0.10564498,-0.02182213,0.04374116,0.0023163555,0.037906777,-0.05659014,-0.0040214895,0.020628134,0.015399573,-0.0014208977,-0.018001717,-0.0249267,-0.038965303,-0.04579867,0.04448941,-0.05662649,0.0066120913,0.05248721,0.018515442,-0.014050803,-0.15435773,0.06601032,0.036377765,-0.009423316,0.05083629,0.036728233,-0.04653437,0.07118514,0.014465254,0.02546119,-0.056307323,-0.07532002,-0.04255273,-0.027997918,-0.024082595,-0.10490498,0.002014213,0.006054999,0.07778518,0.09547698,0.015524849,-0.030554203,-0.06373529,-0.044969812,-0.01870496,0.02582587,0.049237255,0.042478766,0.05100596,0.052706074,-0.038964484,-0.025000751,-0.059296787,-0.0024714582,0.0134037165,0.002399915,0.012040275,-0.05152362,0.013275827,0.047354735,0.08123674,0.041245177,0.012141703,0.06132184,-0.018175827,0.07208046,-0.083750494,-0.014431014,-0.07804475,0.048287004,-0.003965826,-0.004515447,-0.085403204,-0.038244706,-0.08345243,-0.048774287,0.04040614,-0.08260686,-0.06536483,0.04422432,0.029231627,0.028993117,0.014537612,0.027745845,-0.048028417,-0.030046964,0.014945479,0.079215005,-0.09654407,0.056607142,-0.0031224273,2.4046915e-33,0.0068728756,-0.026144091,0.030861838,-0.03669818,-0.0035233495,-0.061940707,0.0052242326,-0.056227677,-0.062847815,-0.025042418,-0.03683058,0.0050269733,0.034751814,0.011968287,-0.00272108,0.009940659,-0.06625398,0.01349584,0.03808154,0.002806803,0.01665479,-0.012660266,-0.08876068,-0.022985438,-0.049010854,-0.0033864502,-0.028353542,-0.00019678747,0.03795758,-0.015221376,-0.04955426,-0.025567468,-0.03091211,-0.016919607,0.0022227666,0.032995798,-0.12791689,-0.08675488,-0.007978877,0.047329254,0.0012075708,0.0011236527,0.047866073,0.03230781,0.03300073,-0.02196897,-0.06967241,0.0450588,-0.025967732,0.008478846,0.036948077,-0.01004362,0.007149563,-0.063078105,0.019993251,0.029058352,0.0147413155,0.03194048,0.034420133,0.0025805654,-0.032030787,0.020336868,-0.0805189,-0.022718647,-0.010299677,0.073694244,-0.10666367,-0.0001480693,-0.1213832,0.026929952,-0.012269596,0.020477585,0.07403322,-0.0031891486,0.124028385,0.026263176,-0.03788617,-0.035527498,0.0730377,0.008298943,-0.059896648,-0.054899976,0.004488996,-0.05233098,-0.07016972,-0.029440926,0.027537031,-0.11100938,0.018214129,0.08597167,0.056739934,-0.066050366,-0.020295732,0.012596562,-0.0313376,-3.3842802e-33,0.041201312,-0.014972875,0.01685167,-0.09030532,-0.012759577,0.0057146326,-0.001594097,-0.034408208,0.03948176,-0.010183747,0.10018624,-0.018660909,-0.046591252,-0.0071691233,-0.072184004,0.041110586,0.019069862,0.01411445,-0.0043315142,0.03478,0.0023734432,0.045020178,0.032163396,0.10731763,-0.008897794,0.010333787,0.014884449,0.07376606,0.019898377,0.032867398,-0.088513955,0.03550567,0.018425398,0.07867014,-0.0097822705,0.075411215,0.02143306,-0.029466582,-0.039388567,-0.014425595,-0.018839817,-0.010105092,-0.09055599,0.11196468,0.033491116,0.13043192,0.010433284,0.007684052,0.032878883,-0.05627752,-0.010198649,0.008815173,-0.010981629,0.049135428,0.087629065,0.13837536,0.02825758,-0.021183543,-0.014851978,-0.034237158,0.09561888,-0.022047041,0.032966908,-0.05252929,0.08547067,0.04591318,-0.0797352,0.08614077,-0.02652079,0.022456134,0.07166278,0.0046555195,0.002264535,-0.03723352,-0.074216776,-0.10627419,0.03902019,-0.09431733,-0.06847146,-0.007001534,0.018697793,0.055607602,-0.040429175,-0.013650259,0.07069526,-0.037874926,0.018842675,0.064538695,-0.053272575,0.029434964,0.026137967,0.10251269,-0.0010957336,0.06444118,0.08829563,-2.9436748e-08,0.055572364,0.008906209,0.00010905192,-0.110725924,-0.030588843,0.0061075217,0.083754644,-0.06736937,-0.027417434,-0.075777195,-0.017222714,0.040655527,0.04007651,-0.00983041,0.1492303,-0.026132235,-0.039183117,0.0018645695,-0.029458473,-0.06478104,-0.060779843,0.0063446164,-0.018023228,-0.06334655,-0.085541084,-0.079222545,0.08109337,0.059407964,-0.022175105,-0.035908245,-0.0073456005,0.022361109,-0.019011255,0.047138873,0.06823546,0.059652783,-0.11211647,-0.036395684,-0.03221093,-0.021637762,-0.034164965,0.0034626878,-0.030924404,0.055772595,0.054897983,0.006254188,-0.028244697,0.010316722,0.018253732,0.029502507,0.045834895,-0.037419464,0.029397974,-0.041048884,-0.07473754,-0.038281012,-0.029164838,0.010808395,-0.042047556,-0.09965679,0.0012323706,-0.033487026,0.21059723,-0.0066438415 +4.1.1.90,"The enzyme can use various vitamin-K derivatives, including menaquinol, but does not contain iron. The mechanism appears to involve the generation of a strong base by oxygenation of vitamin K. It catalyses the post-translational carboxylation of glutamate residues of several proteins of the blood-clotting system. 9--12 glutamate residues are converted to 4-carboxyglutamate (Gla) in a specific domain of the target protein. The 4-pro-S hydrogen of the glutamate residue is removed [5] and there is an inversion of stereochemistry at this position [6].",384,1.0,-0.0048154555,-0.011358861,-0.15148845,-0.0024131695,-0.0467188,0.019207003,0.015633391,0.008688369,0.0070387144,0.016909033,-0.00075599743,-0.0042995363,-0.073265284,0.044727635,-0.056913495,-0.07182486,-0.04078252,0.03369312,-0.031716708,0.014408945,0.018865252,0.0016188334,-0.076361716,-0.097080216,0.033932466,0.04026927,0.07030969,-0.033544607,0.017949842,0.0036000214,0.014235332,-0.057070732,0.07998877,-0.055978566,0.00613599,0.02278034,-0.07265509,-0.106263444,-0.044317212,0.026649388,0.030636214,0.015355303,-0.0071976767,-0.060680613,0.03892744,-0.028799029,0.032174483,-0.0081727775,0.026487999,0.048982225,-0.0023023942,-0.06645456,-0.0503906,0.040801805,-0.0147713525,-0.04771462,-0.076335736,-0.031294484,0.04123922,0.064123936,-0.017370354,-0.0037416779,0.014064596,0.0040290896,0.06303274,-0.08488885,0.010458777,-0.025787547,-0.01936728,-0.03784715,0.06542797,-0.06258984,-0.0064239404,-0.027720513,-0.05105009,0.045563262,-0.0031059303,-0.05115931,0.040143173,0.019013556,0.037982922,0.027485156,0.013815993,0.1342174,-0.00507892,0.070475824,-0.051277824,0.052002557,-0.033502933,0.07161558,0.026985552,-0.007645363,0.028999444,-0.02980065,-0.052365985,0.026481513,-0.00083081704,0.04951381,-0.02055064,-0.034795173,-0.0015380736,0.028367355,-0.009659706,-0.07061049,-0.024454337,0.036806963,-0.026345365,0.12795599,0.028207026,0.021001695,-0.026615249,0.056032375,-0.0025016454,-0.033395886,0.0024996754,0.03822194,0.020956356,-0.03604522,-0.09219346,0.0780717,0.003988487,-0.0036391993,0.01580129,-0.013874325,0.0144148385,0.024509896,-0.029796302,9.310047e-34,0.040468257,0.009693783,0.035978366,0.00068794703,0.045693707,-0.03083285,-0.073778495,-0.01756034,0.03290702,-0.010547424,-0.03498452,-0.027533446,0.010611425,0.0030566757,-0.061907355,-0.022402301,-0.030380521,-0.124781355,0.061439667,0.056894377,0.05928969,0.049460918,-0.016009765,0.017230222,-0.038794592,0.13553046,-0.04374164,0.059186805,0.015314449,0.023773825,-0.053214602,-0.051528927,-0.1011661,-0.01038944,0.050728906,-0.037288763,0.010158736,-0.026562126,-0.030498974,0.098132715,0.111835934,-0.04262242,-0.1281151,0.024117041,0.12931,-0.01541855,-0.031689372,0.1352741,-0.025101593,0.024159761,0.024532234,0.026916444,0.048231084,0.0036904153,-0.07302427,0.07019276,-0.035417754,-0.015357087,0.055217415,0.05161648,0.039591867,0.057256278,-0.023993265,0.057026472,0.022634115,0.015132795,-0.07210251,-0.09018312,-0.014018935,0.029155914,-0.00023347735,0.011965139,0.03377885,0.041338056,0.01992031,-0.040166877,-0.048577916,0.05703761,0.06302629,-0.05318627,0.006049177,0.031419612,0.028375058,0.0013804636,-0.058971662,-0.012961922,-0.004480517,-0.071347766,-0.025106125,-0.07853283,0.023008788,-0.07035007,-0.050562814,-0.022069309,-0.0069315517,-3.340162e-33,0.0947481,-0.08500188,-0.010393124,-0.026566116,0.004825503,0.049895607,0.032226123,-0.024702264,-0.0038063377,0.021934213,0.0451408,0.0014705547,0.010543856,0.0045627877,0.012384076,0.033144537,-0.03511939,0.06952281,-0.058860023,-0.07637154,-0.024375098,0.041294158,0.07110696,0.022027243,0.07036878,-0.0061588064,-0.025998557,-0.016556105,0.04408192,0.14527091,0.03901611,-0.04984189,-0.085452095,-0.08834036,-0.043808497,0.023161175,-0.03446018,0.017262185,0.041896332,0.038277,-0.0036972694,0.009489771,0.040017758,-0.001767241,0.03200632,0.08839061,-0.059351888,0.026229486,-0.008820254,-0.075009964,0.057092484,0.0076270374,-0.11431149,0.0057866764,0.021604627,0.027209688,0.11383149,-0.04458628,0.011198471,-0.018808661,-0.084740944,-0.096271835,0.056829438,-0.016592814,0.039019823,0.06844271,0.11903671,0.041371454,0.055935867,-0.048033133,0.08067195,-0.07225669,0.08716214,-0.004744682,-0.04154958,0.032949366,-0.05048662,-0.050842617,0.039830208,-0.11212991,-0.032479893,-0.06440558,-0.013412788,0.030857129,0.034017492,-0.15114355,-0.0068876706,0.081373945,0.00033041142,0.051048275,-0.07318384,-0.033545982,-0.054320555,0.058084466,0.0269825,-4.339361e-08,0.00734281,-0.029304808,-0.03587081,-0.021763107,0.052273583,0.037136808,-0.12649387,-0.0361707,0.14938052,-0.023361735,0.026165286,0.06229069,-0.07161511,0.044540986,-0.0015111924,0.06400887,0.018761791,0.06005688,-0.004125363,-0.066615336,-0.07488089,0.025306765,-0.027807184,-0.012716071,-0.002679662,-0.07562578,-0.026671315,0.06389043,0.0034554282,-0.009516992,-0.04083452,0.08486234,0.008403633,-0.033842906,-0.06856113,-0.011868327,0.0042474098,0.019099085,-0.011009166,0.010964465,0.008142888,-0.089529105,-0.0310528,0.009877311,-0.06497997,-0.0022188555,0.021523178,0.06301116,-0.05549548,0.010206456,0.04821659,0.015965618,-0.043262597,-0.011060515,-0.042816684,0.0034016285,-0.017773775,-0.10116226,0.02130362,-0.0726281,-0.0539346,0.07079051,0.09704549,-0.04401079 +4.1.99.13,"A flavoprotein (FAD). The overall repair reaction consists of two distinct steps, one of which is light-independent and the other one light-dependent. In the initial light-independent step, a 6-iminium ion is thought to be generated via proton transfer induced by two histidines highly conserved among the (6-4) photolyases. This intermediate spontaneously rearranges to form an oxetane intermediate by intramolecular nucleophilic attack. In the subsequent light-driven reaction, one electron is believed to be transferred from the fully reduced FAD cofactor (FADH-) to the oxetane intermediate thus forming a neutral FADH radical and an anionic oxetane radical, which spontaneously fractures. The excess electron is then back-transferred to the flavin radical restoring the fully reduced flavin cofactor and a pair of pyrimidine bases [2].",384,1.0,-0.078921854,-0.06021065,-0.061471183,0.076550856,0.09733944,-0.00997806,-0.057454314,0.07593243,0.030635199,0.00595992,0.08029333,0.05158489,-0.061477583,0.037957948,-0.02642017,0.08454727,-0.14987141,-0.024911093,-0.038327422,0.075295866,-0.04424633,-0.047697056,0.041653186,-0.05710423,-0.019639403,-0.0081589045,0.028079852,-0.053993892,-0.017544191,-0.043445617,0.071278445,0.0058801346,0.010711381,0.0020554,-0.029299341,0.08891399,-0.0082327975,-0.07370031,0.0011526879,-0.006399124,-0.0019555434,0.0068404013,0.008926592,-0.04624124,0.07002536,-0.008569082,0.032130163,0.057238374,-0.015395735,0.07127921,0.02004552,0.0038129326,-0.08947892,0.06169182,0.014075095,0.059279732,-0.08230626,0.010575361,0.028240787,0.027956424,0.072455116,0.056912586,0.014961943,-0.0040261587,0.023367181,-0.07490474,0.015271841,-0.05736635,0.029743215,-0.01880975,-0.0012184038,-0.047365148,0.006713653,0.0024709217,-0.002201543,-0.000260466,-0.087133676,-0.055440746,-0.008159142,0.011754089,0.054505344,-0.04847455,0.04096137,0.08725755,0.11002233,0.03402579,-0.007525974,0.010206455,0.00991513,0.009861452,-0.05277717,0.008193952,0.0012142867,-0.022446902,0.015598584,0.07855441,0.02929996,-0.010533716,-0.076599635,0.0072618667,0.058242798,0.018438285,-0.060816344,-0.037401855,-0.070550196,-0.080865055,-0.01509575,0.09234452,-0.08367058,0.010776582,0.038681243,-0.019387724,0.047321584,-0.10972765,0.008855578,0.089769,-0.062111724,-0.044342794,-0.039485272,0.009537208,-0.0007984928,0.0631321,0.029039491,0.115689345,0.03609386,-0.0521137,-0.0658212,4.0482795e-33,0.08493235,0.057024024,-0.030166954,0.007217434,0.0029938614,-0.04260108,-0.024233583,-0.06442748,-0.081024036,-0.054710686,-0.0025367404,-0.030689416,0.11811084,-0.043283552,-0.0027298483,-0.049303003,-0.021591244,-0.002797087,0.058389526,-0.061905622,-0.013530085,0.066699624,0.022320945,0.05691952,0.022544548,0.033549618,0.004048036,0.036354672,0.0060083587,0.0036222155,-0.0068113757,0.04338527,-0.031596936,0.018579034,0.005516872,0.0159143,-0.13279413,-0.09515169,-0.08224294,0.018251486,-0.06428709,0.060733184,-0.044699315,-0.031874925,0.07695806,-0.038542833,-0.04817896,0.12900138,0.007687707,0.045272518,0.0034083212,-0.06713741,0.06264619,0.008438376,-0.09358954,0.047643997,-0.0034026764,-0.014295339,0.015830113,0.044840693,0.06975699,0.007195871,-0.011513003,0.06573554,-0.10118686,0.055617403,-0.0363698,-0.025484143,-0.01088963,0.06360445,-0.0208639,-0.010778471,0.0137880305,0.009959162,0.09870355,-0.00045776326,-0.041151524,0.017538842,-0.051253427,0.041899048,0.0049992297,-0.037150636,0.011122855,-0.020587206,-0.038479604,0.043581955,-0.03967592,-0.03981451,-0.017342767,0.04880775,0.12975854,-0.078230694,0.0001670368,-0.07962218,0.008322191,-3.831002e-33,0.054297164,-0.10067778,-0.05590641,-0.03773136,-0.010582995,0.006117148,-0.009797735,-0.031876307,-0.004684148,-0.049522612,0.022890843,0.024318352,-0.09807013,-0.034949094,-0.012063957,-0.019320942,0.040904947,0.06074959,0.074180506,0.021218108,0.02244471,-0.040537637,0.020396568,0.04748328,0.055934068,0.07776312,0.042319536,-0.030067774,0.10060919,0.030871343,-0.060819473,-0.029583769,-0.03951266,-0.0019750188,0.033111356,0.07615105,-0.033058055,-0.033115957,-0.013927554,0.057057213,0.024931133,0.0056960233,0.050309125,0.06021168,0.06570115,0.0064660218,-0.06993747,0.06702711,-0.0011143164,-0.092586346,-0.018791238,-0.018119713,-0.009188835,0.019499406,0.091038294,0.05338346,0.0965959,0.010260704,0.0029764737,-0.0281895,-0.04423979,-0.08995382,0.00821431,-0.004191377,0.015431744,0.027268516,0.030987276,0.079271585,-0.03714357,-0.022643186,0.07465017,0.0027609305,0.023866834,-0.034609165,0.028576646,-0.06302429,0.0006031778,0.048106402,0.004383144,-0.015008174,-0.029424775,-0.043718398,0.030437179,-0.013659181,0.0018432806,-0.08983552,0.013839742,0.04315532,0.01772165,-0.034887906,0.0071504056,0.03542167,0.06356152,-0.070814736,0.04730999,-4.8152135e-08,-0.010711719,-0.100105904,-0.017228726,-0.010093176,0.12162405,0.050883796,-0.02774144,0.015377503,-0.0021712135,-0.033499785,0.0006117992,0.09937357,0.08774717,-0.06537668,-0.010236483,-0.006182881,-0.030139744,0.0017497962,-0.06404851,0.008265515,-0.13134758,-0.00794712,-0.0766005,0.0016281132,-0.051747635,0.047615867,-0.011454472,-0.033872124,0.017468812,-0.03430816,0.07291962,0.019554699,0.06706041,-0.026068078,-0.15647241,-0.009025743,0.0582242,-0.03486463,-0.032772683,-0.0022898982,-0.108158186,0.03905474,-0.013401333,0.057007365,0.07296528,-0.005457794,0.021050083,-0.04522843,-0.09544554,0.003833657,0.015284844,-0.005524099,-0.013034795,-0.023595495,-0.07844812,-0.076948956,0.0233491,-0.0588348,0.010489076,-0.030901767,0.012524746,-0.0062863114,0.12580793,0.07540462 +4.1.99.14,"This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme binds a [4Fe-4S] cluster. The cluster is coordinated by 3 cysteines and an exchangeable SAM molecule [3]. The 5'-deoxy-adenosine radical formed after electron transfer from the [4Fe-4S] cluster to the S-adenosyl-L-methionine, initiates the repair by abstracting the C-6 hydrogen of the spore photoproduct lesion. During the second part of the repair process the SAM molecule is regenerated [3].",384,0.99999994,-0.05860046,-0.10699701,-0.054227676,0.10491788,0.06827929,-0.0061353813,-0.030332379,0.00086745975,-0.010857674,0.0027862361,0.08725858,0.08542272,-0.053542737,0.046689373,-0.00478069,0.103221186,-0.11555095,0.026389234,-0.004368503,-0.01464174,-0.02818028,-0.0012994398,-0.05679189,-0.018636933,0.070390135,0.007576491,0.06889514,-0.061737027,-0.07293468,-0.054558773,0.06405267,-0.05305591,0.04869045,-0.0028109087,0.009059674,0.12454827,-0.014608687,-0.042458985,0.03001758,0.017616246,-0.007578577,0.02693242,-0.041109584,-0.05193143,0.0051697656,-0.025667699,-0.0355375,0.038433433,0.055796593,-0.019746248,-0.0344361,-0.03000005,-0.016337529,0.03393258,0.017796367,0.05633393,-0.07344675,0.016861461,0.022091903,0.019951824,0.102340676,-0.05402869,-0.023455285,-0.0140370205,0.052752163,-0.037152376,0.068717405,-0.056637183,0.04019397,-0.025565477,-0.01255975,0.012684514,0.0016006354,-0.00016947798,-0.03821819,0.013966668,-0.04226578,-0.08299868,0.03775943,0.0033866763,0.05621032,0.03834849,0.043814056,0.04504002,0.13610859,0.05292231,0.016619975,-0.047777515,-0.027345276,0.009903479,-0.08135294,0.03829957,-0.06103755,-0.073917076,-0.030862764,0.032397654,-0.024366984,-0.01831139,-0.0480978,0.0061642164,-0.02386789,0.074832164,-0.06261511,-0.10536944,-0.0040509608,-0.031715617,-0.06607757,0.09911075,0.017082773,0.06026388,0.07337035,0.071540855,0.065968424,-0.013076066,-0.020041754,0.076345816,-0.04224449,-0.042450186,-0.06067504,0.013597073,-0.012080139,0.055885118,-0.012961068,0.013056308,-0.008685151,-0.011268629,-0.057204075,5.565238e-34,0.07937004,0.028063003,0.07408635,0.013191168,0.018582145,-0.040446777,-0.08357876,-0.041360777,-0.044986624,-0.045162573,-0.03666726,-0.097681604,0.09199629,-0.04666004,-0.06735532,-0.03820116,-0.023276674,0.027979884,0.034822103,0.0013029211,-0.13333513,0.030658491,-0.10169584,0.02097935,-0.009685189,0.056186415,0.031317964,-0.012321007,0.049058173,0.03467593,-0.06670846,0.08943254,-0.08685308,0.04688684,-0.03862994,-0.05394855,-0.012420291,-0.12744182,-0.01076231,-0.033293936,-0.0033852784,0.042459354,0.022259304,0.021037523,0.021764258,-0.0008119051,0.022476548,0.052227255,0.024142116,0.07600344,0.011249052,-0.037976492,0.09921747,0.010915982,-0.09265064,-0.055438057,-0.025503086,-0.023192398,0.035222217,0.07181971,0.027980374,0.006330101,-0.03292204,0.047006622,-0.018348776,-0.01227177,-0.06526167,-0.013933199,-0.035962045,0.08741624,-0.00057749747,0.030428417,0.071059816,0.03461357,-0.07703233,0.022629188,0.041016933,0.05793839,-0.02498977,0.04349967,-0.047103733,-0.04047792,-0.01128478,-0.050503794,-0.04390389,-0.033019736,0.01718638,-0.022766786,-0.01614017,-0.01819843,0.060571313,-0.041372597,-0.06832494,0.014838494,-0.031119984,-2.3172502e-33,0.06743518,-0.08215342,-0.0006176937,-0.04871994,-0.06285013,0.06077884,-0.05342371,0.041879933,0.032061566,-0.041331086,0.035017956,-0.021377468,-0.014710278,-0.09940439,0.044223502,0.037664093,-0.005540041,0.0020467816,-0.008131321,-0.013214784,0.059343338,0.07833501,0.053418685,0.036989916,0.08313664,-0.008736546,0.04604161,0.032361988,0.0707542,0.06440412,0.082941465,-0.059947938,-0.09125336,0.07583157,0.042431753,0.075920254,0.023449482,-0.018941164,0.0017653453,-0.00103711,-0.017283108,0.014461538,0.004178054,0.1943932,0.086353764,0.049256768,0.019139271,0.028028224,-0.03544221,-0.10937873,-0.00103085,-0.06114136,-0.0010600361,0.014679769,-0.015185024,0.057204228,0.033995703,-0.01140627,-0.11460794,-0.030565998,-0.045715813,-0.06846372,0.046079606,0.03158698,-0.022977851,-0.0002199534,0.04495739,0.028257012,-0.02975978,-0.012055095,0.0026269464,0.026565608,-0.024731992,0.05709909,-0.014590125,-0.011566974,-0.07089313,0.031285282,-0.006569972,0.03062561,-0.03503824,0.005597725,-0.03077574,-0.051408943,0.09474796,-0.018434552,0.026505738,0.100597076,0.007830228,-0.041811142,-0.082560785,0.026834458,-0.002480932,-0.019035429,0.008402949,-4.1168096e-08,0.052564453,-0.08755801,0.022601215,-0.056779884,0.038089585,0.011576743,-0.0015629772,0.08606185,-0.020727638,-0.041841935,-0.062372454,0.09158158,-0.026635792,-0.010067721,-0.019441906,-0.03040049,-0.038094442,0.027305113,-0.028895253,0.005418138,-0.07979124,-0.08227357,-0.051566508,0.024091631,-0.06416177,0.03324062,0.10933588,0.03992074,-0.034132086,-0.037349705,0.106797054,-0.02822545,-0.011404469,0.048086893,-0.12671623,-0.043534175,-0.019997535,0.013280176,-0.02081952,0.076637946,-0.022882182,-0.05575544,-0.033354834,0.05086824,-0.080197036,0.024622072,0.0032120715,-0.016944293,-0.016420623,-0.010747535,0.02032854,0.013698301,-0.07937337,0.0061845058,-0.07935662,-0.032601766,0.02981656,-0.025811506,0.09511208,-0.014339075,-0.03375005,0.034780238,0.059783444,0.03143955 +4.1.99.15,"An iron-sulfur protein (contains one [4Fe-4S]2+ per enzyme monomer). The 5'-deoxy-adenosine radical formed after electron transfer from the [4Fe-4S] cluster to the S-adenosyl-L-methionine, initiates the repair by abstracting the C-6 hydrogen of the spore photoproduct lesion. The C–C bond linking the two pyrimidines undergoes fragmentation to give an allyl-type radical. The thermodynamically problematic last step is the transfer of the hydrogen atom back from the 5'-deoxyadenosine to the thymine monomer radical, which completes the repair process [3]. The enzyme from Bacillus subtilis is specific for the (5S)-configured spore photoproduct [4]. For the enzyme from Clostridium acetobutylicum a (5R)-specificity was demonstrated with spore photoproduct in double-helical DNA (cf. EC 4.1.99.14 [R-specific spore photoproduct lyase]).",384,0.99999994,-0.055122517,-0.06175825,-0.012029172,0.0041533615,0.08893165,-0.011032442,-0.08284007,0.03915748,-0.029133806,-0.0071988697,0.07313274,0.018404935,-0.0057816957,0.054625846,0.012306612,0.04556262,-0.102818884,-0.019056102,-0.002157735,0.0027621249,-0.02257024,-0.013004489,-0.06215405,-0.022077166,0.034871977,0.04317269,0.052983437,-0.070776775,-0.115206145,-0.046819966,0.007487523,-0.09388673,0.0009219205,-0.02928821,0.0732855,0.12372538,-0.025582273,-0.0015297285,0.08412785,-0.019850483,-0.025036752,0.010043753,-0.10686758,-0.016744561,-0.083000794,0.003262485,0.036979303,0.021816028,0.009152355,-0.020151092,-0.021423323,0.016253445,0.0021533796,0.010873995,0.025140958,0.042647686,-0.06302758,0.018713212,0.04134019,0.0033246968,0.02405982,-0.057656202,0.0013612849,-0.009399679,0.055372648,-0.042157874,0.10838556,-0.06571377,0.022269096,-0.03244352,-0.006654939,0.019079683,0.028058466,0.029425547,-0.012478207,0.011889305,-0.010719735,-0.09045678,0.033332173,-0.010388034,-0.0284211,0.027702931,0.03652526,0.025454342,0.12377229,0.013562152,0.041162767,-0.0399425,0.026193963,0.012128983,-0.034145202,0.02256177,-0.022469085,-0.08063621,0.005368561,0.055964213,-0.04498512,0.0243937,-0.01669319,-0.020057017,0.020631468,0.01503603,-0.0849851,-0.071373895,0.025615215,-0.08609803,-0.026935237,0.12073438,0.044606816,0.039941605,0.056852963,0.07841043,0.088535085,-0.05427306,0.01137636,0.037036512,-0.020728689,-0.048536625,-0.047840774,-0.027142974,0.022229072,0.071360335,0.00235174,0.034192823,-0.016339805,-0.013459733,-0.09493112,5.420425e-33,0.05323138,0.04561264,0.08254333,0.036020614,-0.009282049,-0.031722255,-0.090111054,0.01022139,-0.10053371,-0.036152713,-0.04856103,-0.13949858,0.09329921,-0.030490912,-0.09173575,-0.023359954,-0.023971237,0.08529543,0.0023396579,0.03087838,-0.06949481,0.029203603,0.035067156,0.061320845,0.03517574,0.053943172,0.04108165,-0.011852711,0.04418485,0.0017360009,-0.03606628,0.021923767,-0.055380385,0.040111568,0.06393104,-0.06166127,0.0023737387,-0.058978386,-0.071273394,0.0072257235,-0.0090136565,0.098443605,-0.028657535,-0.019804958,0.047303747,-0.014175978,-0.019264797,0.1129919,-0.034258373,0.03195154,0.015489026,-0.027846433,0.11633919,-0.03311493,-0.07577185,0.01263524,0.009269091,-0.037215736,0.060241837,0.06801346,0.047760993,0.11106153,0.0025085069,0.019470189,-0.0012801621,0.0012046635,-0.091098234,0.04738551,0.043356422,0.06428015,-0.025101824,0.051524132,0.0054452536,0.043612435,0.0057165683,0.015207473,-0.053424306,-0.01354127,-0.044037692,0.07184857,-0.035798166,-0.060160514,0.013621833,-0.08019468,-0.09988495,-0.031353205,-0.053574156,-0.038169336,-0.012692305,0.027997423,0.085413314,-0.10094067,-0.045351576,-0.020793866,-0.087749675,-4.8565365e-33,0.074796066,-0.08130706,0.030059585,-0.063335314,-0.06274429,0.03731315,-0.03304215,0.0051993625,-0.00047560135,-0.03882311,0.07715733,0.031173361,-0.041582175,-0.062185362,-0.028859738,0.0936388,0.016829021,0.026127102,0.032527663,0.01401819,0.043894153,0.057660833,0.02197531,0.025239175,0.09029984,0.063245006,0.031153234,0.03787052,0.14018361,-0.008273442,0.023373604,-0.016721133,-0.058489364,0.019917484,0.045087453,0.055417296,-0.02893365,-0.017621964,0.08342068,-0.01588278,-0.02465185,0.028638301,-0.01043396,0.15376505,0.052892495,-0.0069339247,-0.03404457,-0.009955676,-0.0004193812,-0.060602855,-0.023820223,-0.07965809,-0.004047492,-0.00893747,0.03316307,-0.023078982,-0.0053911046,0.021886578,-0.083130606,-0.0412291,-0.041688755,-0.080977485,0.06727243,0.040773973,0.0049106344,0.0047814357,-0.03010512,0.036054846,-0.040682923,-0.06588093,-0.0095525505,0.03622074,0.008446803,-0.020393115,-0.015341183,0.0030183594,-0.0169567,0.067241326,0.03612211,0.09258428,-0.054987855,-0.014904822,-0.036106423,-0.07514752,0.11120907,-0.024071671,0.012375121,0.087897174,-0.0067627933,-0.046899837,-0.08926702,-0.014832826,0.07675827,-0.0058660647,0.04161785,-5.184104e-08,0.0561556,-0.06880992,0.03495493,-0.015059409,0.07059296,0.026373062,-0.024796458,0.00676017,0.02730809,-0.048627343,-0.03764831,0.11777278,0.00068017223,-0.009471316,-0.013525028,-0.027669784,-0.069947235,-0.0020017412,-0.007779997,0.014856749,-0.11148527,-0.064433455,-0.107414804,0.06506562,0.018296089,-0.014845908,0.049663514,-0.030871771,-0.0055001536,-0.052008223,0.03160246,-0.041804187,0.022343699,-0.0034107934,-0.020399733,-0.047924228,-0.089252144,0.05936756,0.0031074833,0.08686487,-0.0052028205,0.0060276403,-0.06274223,0.03827668,-0.020055424,0.009085869,-0.042749755,0.028409814,-0.1041851,-0.014009967,0.06310338,0.04189627,-0.033185672,0.015389719,-0.07755246,0.02440982,0.05724109,-0.07035269,0.062214844,0.024732044,-0.039795112,-0.0016172968,0.072109886,0.025590416 +4.2.1.116,"Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA [2].",384,1.0,-0.0486541,-0.06039643,-0.008043383,-0.01908372,0.06313813,-0.009496447,-0.10365532,-0.016738856,-0.016720451,-0.04497278,-0.014284257,-0.16462688,0.015355195,-0.054631513,-0.047519404,-0.017797703,-0.06589898,-0.024193432,0.055540077,-0.019795721,0.08855449,0.045153048,-0.047013674,0.03970477,0.0038877972,0.07447167,0.0076613515,-0.08375601,-0.02959513,-0.050330475,-0.010379936,-0.020197773,0.045749232,-0.06616356,0.07824189,0.05956248,-0.033421285,-0.0061425557,0.06675439,0.005421315,0.013429397,0.00032120978,0.047185898,-0.024884231,-0.06557013,-0.007417907,0.08285617,-0.054547507,0.045020726,-0.02980611,-0.047002517,-0.089908324,-0.09544021,0.042965274,0.012486264,0.023799403,0.045004968,0.0010383893,0.062534004,0.01478897,0.10836839,-0.011559058,-0.013513401,0.02317437,0.03310081,-0.028997464,0.024956184,-0.027813004,-0.0053203367,0.0120082935,-0.073574536,-0.023430832,-0.0036874136,-0.0113707995,-0.0035832191,0.0735216,0.006172761,-0.10617103,0.08433794,-0.025184033,-0.050280817,-0.004761983,0.021668384,0.017060928,0.01716155,-0.027805924,0.0011780252,-0.050902236,0.10251823,0.045366473,0.013825388,0.02683457,0.044800643,-0.07220527,-0.0484881,0.07980309,0.045069523,0.040283103,0.07679366,-0.027436856,0.023832424,0.0683363,-0.004439533,-0.14088596,-0.043787643,-0.022406695,-0.045736607,0.14809175,0.099886924,0.020957442,-0.019340934,-0.034767885,0.05472892,0.021664564,-0.031530187,0.12557617,0.010146492,-0.04302236,-0.08391898,-0.008183123,-0.022220297,-0.029591678,0.07502252,-0.027345432,-0.021110002,-0.0029284,-0.09979041,5.0542782e-33,0.069727756,-0.003399494,-1.7421198e-05,-0.017124116,0.045141738,-0.06715627,-0.12910259,-0.011596476,-0.014090055,-0.026021736,0.00036967534,-0.03132164,0.034488674,0.010185642,-0.08390807,-0.08252795,-0.023717355,0.0018366015,-0.0072141862,0.020478508,0.0027916522,0.01669464,0.003542822,-0.0042885533,0.020500857,-0.0069611184,0.08073796,0.017043725,0.026550373,0.022940416,-0.0045582694,-0.08464027,-0.10970101,0.0028955222,0.15909508,-0.08515873,0.016745094,-0.058379672,-0.09733043,0.0530059,-0.031755053,0.04336927,-0.0060365926,-0.03709952,0.07841008,-0.0512982,0.0016657906,0.15412843,0.007607375,0.061390646,0.003018553,0.010809134,0.05709818,-0.004555029,-0.08505669,0.018510913,-0.053966418,-0.007581883,0.06928567,-0.016010547,0.030955039,0.06845367,-0.0037838782,0.0042348024,0.007975493,0.066714495,-0.011182846,0.022039589,0.05932564,0.08336318,-0.021407735,-0.035506457,-0.005865809,0.08633333,0.03655925,-0.049931105,-0.049880028,-0.06062468,0.02732643,0.011014936,-0.033991627,0.010392312,0.08790162,-0.054266367,-0.018117694,-0.020646574,-0.015325471,0.025984144,-0.0020936257,0.04405226,0.086389154,-0.075468175,0.021231713,0.04388713,-0.04905069,-5.177235e-33,0.055823237,-0.12323564,0.03816665,-0.10890266,-0.074139364,0.010676598,0.013993873,-0.022466613,0.04075321,-0.0026168018,0.09715055,0.070585,0.019049345,-0.030548787,0.033091493,-0.038923167,0.056677002,0.016267337,0.005119912,0.01997049,0.12557974,-0.022028344,-0.031158743,0.05909945,0.051136702,0.033403482,-0.011695799,0.043580312,0.044144206,0.10652498,0.012787983,0.025606496,0.01215756,-0.04409898,-0.10445823,0.05801378,-0.041375976,-0.009748688,0.010841564,0.0496655,0.0039947135,0.021157779,-0.024666412,0.07088726,0.034652315,0.005306909,-0.07661528,0.065849334,0.04527359,0.0011683946,0.020136395,-0.042460915,-0.00095648505,-0.07451761,0.019843841,0.039139964,-0.012877209,0.033794142,-0.067700915,-0.024755877,-0.059940316,-0.042638365,0.07356708,-0.018351885,0.047441907,0.07900099,-0.006913614,-0.008532733,0.0053087664,-0.0019844794,0.059867803,-0.0035012413,-0.026878798,-0.024844583,0.032358505,-0.036517028,0.002359001,-0.03154965,-0.028876912,-0.0050479327,-0.007266007,0.012376814,0.06691767,-0.0746556,-0.0440513,-0.11718938,0.009391576,0.064024396,-0.06962201,0.04166817,-0.07078016,-0.029204391,-0.012334974,0.056535877,0.08193749,-4.096848e-08,-0.025607036,0.010801242,0.10300626,0.014831308,0.00394878,0.05473295,-0.016741078,-0.043375805,0.079762086,-0.045942474,0.00852677,0.033430018,0.073586166,-0.031873386,-0.031567786,-0.008857443,-0.015609354,0.03589195,-0.044921204,-0.021311361,-0.0094656125,-0.050109584,-0.055937693,0.005921002,0.03390542,-0.04177312,0.046769,0.05791365,-0.063028544,-0.046019927,-0.054406866,0.021837842,-0.013368589,-0.03663552,-0.057225935,-0.021095647,-0.034409594,-0.036727846,-0.028498933,-0.019183451,0.0023861662,0.03825074,-0.06488713,0.016213963,-0.006311445,0.016137851,-0.041917145,0.076796256,-0.0398495,-0.02771761,0.07566779,-0.039395984,0.014882668,-0.0033823953,-0.0054360367,-0.010033603,0.030430978,-0.05223261,-0.09315038,0.03429984,-0.026163582,-0.023296203,0.13056614,-0.07399701 +4.2.1.117,"Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates [1]. An iron-sulfur protein.",384,0.99999994,-0.028188057,-0.045387164,-0.07414204,0.056316826,0.07667749,-0.015759874,-0.05882,0.05015824,0.00041317855,-0.08014052,0.04041902,-0.09750613,-0.035660956,-0.040000744,-0.0004140989,0.025893096,-0.033360116,0.041146994,0.019267209,-0.057881735,0.060157474,-0.00840961,-0.05599973,-0.03746267,-0.0011574324,0.064299546,0.020832377,-0.021850333,-0.027685639,-0.055800643,-0.03360907,-0.051937874,-0.0070755184,-0.048832588,0.050459843,0.06281237,0.01403057,-0.12512124,0.04793,-0.052852355,0.051889013,0.05142916,0.014459297,-0.05466362,-0.076489314,-0.03132467,0.03677024,0.05072335,-0.027740208,-0.025994504,-0.06047429,-0.044911757,-0.0020007626,0.020668399,-0.024920348,-0.026858054,0.021206418,0.0030692874,-0.05889246,-0.065427795,0.05561234,-0.035486765,-0.023345524,-0.047948264,0.046926226,-0.057840027,0.069314145,-0.036270097,0.054700587,-0.017522743,-0.09560798,-0.015665213,-0.033975314,0.06663714,-0.011677638,0.028435336,0.03907721,-0.028304983,0.055233173,-0.04439535,-0.014798295,-0.033435408,0.113369584,0.021795897,0.012288397,-0.006746294,-0.05387416,0.028141737,0.058543883,0.054793376,-0.018075075,0.05383585,0.02820267,-0.034160364,-0.04106299,0.057291687,-0.008965362,0.049303453,0.022859106,-0.02336726,0.010173491,0.11950399,-0.11709533,-0.03896207,0.029388083,0.03409587,-0.019859066,0.105624065,0.05650211,0.08724427,0.011087028,-0.0816803,0.0035585582,-0.026684059,-0.022084078,0.14798982,-0.020972176,-0.035836183,-0.031549443,-0.054578204,-0.026441973,-0.012534745,0.02001672,0.017197838,-0.020389903,-0.014760453,-0.11468388,1.6279996e-33,-0.03001061,0.04647762,0.021809924,0.007453065,0.0006481956,-0.027647618,-0.063366145,0.045175284,0.0015958915,-0.03745262,-0.10642204,-0.10525687,0.0523227,-0.0039733527,-0.041426826,-0.094979875,0.044242837,0.022469183,0.09033251,-0.0032683709,0.012676143,0.086422585,0.013563569,-0.06749804,0.05380691,0.037633523,0.014526131,0.04661174,-0.003381803,-0.013386956,0.035747405,-0.05826653,-0.136126,-0.013291615,0.114530765,0.035602633,-0.011677926,-0.011334823,-0.013373778,0.08776572,0.07401138,0.04025342,0.0040205563,-0.04604073,0.073642276,-0.036823455,-0.05729007,0.057682138,-0.04084012,-0.02583297,-0.0016222784,0.039697524,0.09321785,-0.01834556,-0.103851065,-0.009343698,0.061509334,-0.017911706,0.045704994,0.055768035,-0.013870446,0.08835984,-0.02530079,0.029607816,0.004837134,0.047085896,-0.073840745,0.00028106812,0.04976578,0.08368458,-0.065210104,-0.0145713,0.08071971,-0.044444855,-0.0011094176,-0.0714173,-0.11664467,-0.03206352,0.029378403,0.041215524,-0.002417146,-0.0018674087,-0.00602579,-0.02516665,-0.06630966,-0.010985888,-0.032034107,0.012296297,0.04788707,0.03209602,0.05935417,0.014353963,-0.02215024,0.021394914,-0.0032277624,-3.4398124e-33,0.032874845,-0.031365212,-0.01772179,-0.061004177,-0.07144176,0.024829622,0.02064242,0.03928413,-0.009152136,-0.017023835,0.1392869,-0.010846783,-0.016099706,-0.08456853,0.009845932,0.063005395,-0.025454167,0.07393538,0.036015138,-0.0069105127,-0.021376485,0.051558916,-0.02783776,0.07121848,-0.055909723,-0.0056952504,0.06995972,-0.003511395,0.12761569,0.073830426,0.05241197,0.0053520957,0.023087056,-0.1194488,0.0030808852,0.023867361,-0.08241086,-0.007960141,0.059702065,0.07795862,0.04652109,0.012335751,0.026161768,0.10269118,0.05417695,0.04696779,-0.086947344,-0.023880308,-0.07540324,-0.03796922,0.07947185,-0.0602493,-0.0554579,0.05206421,0.06771188,0.034440383,0.020704165,0.027997706,-0.06666747,-0.0051090145,-0.045566466,-0.03321224,0.024830721,0.015094751,0.07647883,0.020129327,-0.026076045,0.027746854,0.013558351,0.020552378,0.03897494,0.018828623,-0.0017534917,-0.050992627,-0.011092938,-0.038669575,-0.07520487,0.013209862,-0.028685732,4.9590606e-05,-0.021749256,-0.01925697,0.02187031,-0.06493216,0.035800267,-0.10208205,0.018093087,0.08959978,-0.040407497,0.038629487,-0.011037647,-0.09281483,-0.014646464,0.050702058,0.0048481515,-4.70097e-08,-0.036640014,-0.0649327,0.072943464,0.039073322,-0.04909003,0.11585616,-0.03236689,-0.017620718,0.067935765,0.008818231,-0.083828494,0.030323012,0.040841136,-0.029047806,0.011753588,0.0026132858,0.014886722,0.044132266,-0.0042728144,-0.0016859502,-0.11474148,-0.023722528,-0.057586636,-0.05221552,0.05662228,-0.013455882,0.02067365,-0.008246239,0.009339635,-0.048163857,-0.047636174,0.029967397,0.005063742,-0.02261646,-0.011763937,-0.05427717,0.02915822,-0.056895517,-0.02657036,0.050715797,-0.008053077,0.04112595,-0.12458376,0.023801908,0.065740645,0.012518396,0.03294376,0.044113778,-0.09944496,-0.017549055,0.032620937,0.0066711525,0.014710107,-0.04199729,-0.0060153552,0.013591634,-0.064389445,-0.0071981973,-0.04961809,0.061104026,0.10977021,-0.028842539,0.1059764,-0.060295526 +4.2.1.118,"Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+. 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The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units [1]. The enzymes from Aeromonas caviae [4] and Arabidopsis thaliana [5] are monofunctional enzymes. 2-Enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2 [3].",384,0.99999994,-0.031380266,-0.048870936,-0.040576883,0.01248068,0.09667011,-0.010967447,-0.10789507,0.025009904,0.033435315,-0.07298293,-0.008120873,-0.12089331,-0.08892918,0.013779009,-0.049741335,0.048173286,-0.06278488,0.020836782,0.050769977,-0.032874446,0.0927807,-0.006496532,0.0055459654,-0.011311004,0.034823976,0.072728105,0.05496588,0.027102355,-0.0036839277,-0.12979198,-0.017406939,-0.01096922,0.04510473,-0.051063467,-0.016088462,0.07621524,-0.006417494,-0.07282133,0.011947717,-0.032916747,0.02379939,-0.02420934,-0.053966682,-0.010565431,-0.022723638,-0.060615323,0.033463974,0.015718644,0.06332412,-0.007937509,-0.036688805,-0.055143323,-0.04255655,0.021762526,0.021270838,-0.01221856,0.008775253,-0.0006663156,-0.06937361,-0.029057615,0.07790017,-0.027941205,-0.00830012,0.017437644,0.06932194,-0.014893521,-0.018795261,-0.06427696,0.0025692852,-0.102931626,-0.109279536,-0.068471245,0.028433852,0.03662499,-0.0368319,0.05222273,0.0020697,0.011907167,0.052570008,-0.008867594,0.026952386,-0.022624072,0.07468211,0.04199075,0.045485497,-0.025988523,-0.034393985,-0.002023619,0.022616709,0.03217308,0.013436926,0.081938654,0.05050245,-0.00531113,-0.032438114,0.091588795,0.0122313835,0.04054398,-0.008846332,-0.038563527,-0.027077757,0.11377081,-0.0004691833,-0.06725345,0.08552454,0.048403177,-0.0033775808,0.08218723,0.07625801,-0.030388607,0.019669583,-0.011187517,0.044789348,0.079401456,0.013753329,0.0752702,-0.007376319,-0.019200511,-0.02763428,-0.0039856685,0.0041728537,-0.06282473,0.0017549398,-0.08874867,-0.031947423,0.03660738,-0.08300791,5.099456e-33,0.050219703,0.034694664,-0.045537133,0.060397323,0.04172563,-0.016411524,-0.06932549,0.045879543,0.0013098222,0.01876654,-0.06674837,-0.058756035,-0.005169605,0.054711875,0.014787636,-0.067193314,0.04038658,-0.038946424,0.08914625,0.019674838,0.04541266,0.0647228,-0.060692288,-0.04523626,0.0385,0.052574866,0.046566173,0.01998351,0.065905504,0.007297635,0.03102609,-0.11571724,-0.08642332,-0.0077073816,0.021701274,-0.099257566,-0.054145556,-0.016948273,-0.056861624,0.053359177,-0.004563881,0.033686887,0.0022613434,-0.07761149,0.009272194,-0.07741851,-0.022855885,0.11673632,0.044032015,0.052472007,0.012150316,0.03176249,0.033559155,0.024120275,-0.0057809227,0.033415817,-0.031518165,0.028527655,0.0269679,0.033500876,-0.05896518,0.039958164,-0.0051808273,0.020538291,-0.038731664,0.0069780163,-0.08935053,0.0010774592,0.0014972105,0.12822296,-0.006263023,0.0326548,0.035487253,0.06551581,0.023646642,-0.0868973,0.049199503,-0.035756398,0.0597236,0.021193212,-0.021773336,0.005153725,0.06285196,0.0029195794,-0.034910616,-0.014663143,-0.023348086,-0.058686417,0.0055566635,0.05869357,0.010241264,-0.0014342833,-0.05104449,0.013877128,0.03433957,-5.245423e-33,0.10525241,-0.07744959,0.047965214,-0.18044035,-0.06492311,0.087738745,0.01115847,-0.016329018,0.021012198,0.0008469363,0.06913737,0.0458816,0.046951283,-0.08322441,0.010123864,0.05377638,-0.0011532736,-0.0051358417,-0.01611696,-0.027965112,0.040360354,0.115032874,0.019908132,0.039627247,0.035499312,0.010603745,0.044318635,0.01023961,0.022142313,0.074636936,0.015423286,0.025903946,0.0348371,0.04345713,-0.06578685,-0.005579654,-0.0032779744,-0.00010797251,0.01233882,0.08388865,0.0014981828,-0.008445727,-0.0088620335,0.014480444,0.03374399,0.052937392,-0.05229162,-0.045249,-0.03212981,-0.0768668,0.016384035,-0.056375112,-0.08574478,0.06189855,0.016427655,-0.0041235033,0.032561954,-0.03107963,0.004509333,-0.03720435,0.0153928595,-0.040427063,0.034835488,-0.016897755,0.005226225,0.030034693,-0.05649924,0.042749304,-0.04882917,0.040231336,0.044415783,-0.08661999,0.0021270148,0.049099263,-0.007447491,-0.0016918458,-0.06841775,-0.03196376,0.01381461,-0.058335397,0.0016631848,0.025593,-0.009935786,-0.060652323,-0.09067638,-0.118818246,0.056131065,0.124736674,-0.008517717,0.023920698,-0.02653132,0.0030404753,-0.10982124,0.07371838,0.13200049,-4.5768033e-08,-0.044950254,-0.102049135,0.0674533,-0.0028992302,-0.050018936,0.052065153,-0.07893163,0.033516083,0.0688284,-0.010800429,-0.059177835,0.06413462,0.01275092,0.010946775,0.04358582,-0.010939129,0.02976514,0.007392399,-0.038309276,-0.04692813,-0.06112691,0.01299802,-0.06907799,0.016777031,0.00938827,-0.04072933,-0.03673029,-0.027837131,0.0007379143,-0.002003685,-0.051778097,0.04603243,-0.0008752386,-0.079360634,-0.06422289,0.027851384,0.030029427,-0.08265941,-0.049657557,0.021566533,0.06369366,-0.053205974,-0.055707145,0.015540962,0.02266245,0.0051631737,0.015428684,0.035531152,-0.008972219,-0.038853053,0.077511944,-0.033010386,-0.008410173,-0.021635935,-0.11422622,0.04554333,-0.08596559,-0.045782402,-0.009477603,-0.08615448,0.059736777,-0.0130372085,0.15571146,-0.11646875 +4.2.1.120,"Contains FAD and a [4Fe-4S] iron-sulfur cluster. The enzyme has been characterized from several microorganisms, including Clostridium kluyveri, where it participates in succinate fermentation [1,2], Clostridium aminobutyricum, where it participates in 4-aminobutyrate degradation [3,4], and Metallosphaera sedula, where it participates in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [5].",384,1.0,0.011194152,-0.037559275,-0.1018759,-0.00737614,0.08589013,0.0078007146,-0.09523574,-0.0011596576,0.025951369,-0.07474887,-0.015415877,-0.058021523,0.027474988,0.003947072,-0.085257515,-0.009000388,-0.03602301,-0.041744966,0.048824858,-0.023862291,0.072106265,0.031188814,-0.018615583,-0.013570365,-0.017431172,0.06806738,0.03290183,-0.071855366,-0.070838824,-0.021475954,-0.00908147,-0.021636968,0.023433307,-0.041964587,0.06801135,0.097626805,-0.0022151906,0.0071001393,0.09243159,-0.009583147,-0.0012266288,0.028817797,-0.006320268,-0.02452223,-0.059369985,0.017402103,0.008867742,-0.0435227,0.029248683,-0.02362557,-0.045987193,-0.09782909,-0.022318145,0.0781052,0.04784357,0.029154047,-0.033367977,-0.065106876,0.03894594,0.001428084,0.07199257,-0.05149536,0.024725594,0.008907901,0.047210425,0.002532161,0.031885255,-0.034493595,-0.003153394,-0.040637888,-0.026191363,0.0006349127,-0.0008528724,0.02402382,0.02843662,0.080474146,0.010658628,-0.11272507,0.063931,-0.06503297,-0.018476715,0.022743002,0.028888749,0.027069723,0.03878029,-0.042299163,0.063097864,-0.069052994,0.03918867,0.05500296,0.018688615,0.049623735,0.025101751,-0.10131586,-0.04969917,0.07771242,0.02058394,0.01727194,0.059132196,-0.039049685,-0.027425537,0.066185035,-0.008163226,-0.09924819,-0.07217399,-0.078148454,-0.010495594,0.1724155,0.024481546,0.022572398,0.008483477,-0.006333117,0.035022527,-0.018307628,0.044602618,0.07682239,0.101308085,-0.02235737,-0.06741842,-0.021770066,-0.022288818,0.035471752,0.050672367,0.038755104,0.011606718,0.030941755,-0.1459423,2.9240468e-33,0.0937677,-0.005298237,0.018173685,-0.024749909,0.02621753,-0.04221235,-0.12481072,0.017102903,0.014971921,-0.008401678,-0.03707381,-0.08300741,0.035351783,-0.031138953,-0.02828961,-0.06392872,-0.043222502,0.01069351,0.055219322,-0.03194925,0.008507501,0.07121188,0.042697567,0.0071714665,0.016732281,0.02822294,0.034619972,0.03935993,-0.011037972,-0.0070287236,0.050914377,-0.05118096,-0.13260564,-0.061468083,0.12029752,-0.020139413,-0.008497044,-0.01736268,-0.1137561,0.03163908,-0.02606239,0.05407677,-0.01807801,-0.024802933,0.07914282,-0.076130524,-0.033067316,0.1322021,0.013844067,0.043411616,-0.021599157,0.0053836307,0.09074175,-0.002660101,-0.07692755,0.03483678,-0.0066337516,-0.034575716,0.07344147,0.0022245701,0.059701964,0.074994594,-0.033274993,0.043756787,0.042661075,-0.016820753,-0.038275167,0.005078157,0.05073753,0.12657411,-0.027991774,-0.0465546,-0.02885974,0.039140068,0.030785736,-0.07910178,-0.087004974,-0.07514011,0.0017703528,0.028197527,-0.03479445,-0.04972924,0.036120817,-0.03749998,-0.020302542,-0.0016732994,-0.051762648,-0.029527275,0.02545552,-0.009346731,0.008789205,-0.045428973,-0.019552786,0.04373849,-0.04996947,-4.249076e-33,0.09429605,-0.10470523,0.08386878,-0.039413117,-0.07338775,0.059853468,-0.03940091,0.0536033,-0.01572668,-0.00901867,0.11413847,0.034527227,0.03849615,-0.044864815,0.06671068,0.03395001,-0.015012856,0.007403438,0.030228006,0.030762725,0.018391714,0.0823336,0.0035478624,0.006124511,0.08419409,0.022735229,0.025380285,0.061135557,0.04463176,0.06916631,0.015343971,0.045580566,-0.025353761,-0.057097517,-0.10105313,-0.008459653,-0.04642622,-0.024178918,0.03639164,-0.005837127,0.015039126,0.0411329,-0.02762704,0.09555551,0.025303157,-0.00057644775,-0.060290366,0.07755086,0.058123227,0.010364886,-0.001134744,-0.10467755,-0.03750446,-0.0659696,0.048204906,-0.0067260535,-0.041959,0.051461034,-0.06662629,-0.013634037,-0.056468554,-0.09600715,0.079898,0.013058438,0.070689686,0.05139034,-0.020274777,0.022631865,0.001985148,0.0073774657,0.021830061,0.016207315,-0.042461637,-0.013484377,0.008634796,-0.017257636,-0.039617177,0.06672382,-0.02091747,0.07217673,-0.019997995,0.031421334,-0.005782007,-0.052945685,-0.010221217,-0.12444208,0.009107546,0.09818948,-0.030594835,0.04100759,-0.081048794,-0.01675737,-0.019894606,0.00023868585,-0.023781044,-4.243614e-08,0.014084621,0.012389823,0.10172152,-0.002593515,0.028676754,-0.010239242,-0.03749793,-0.045526404,0.027253395,-0.04578115,-0.0066955965,0.08767515,0.021387931,-0.033935882,-0.007107148,0.010076139,-0.07965358,0.052100208,-0.027677255,0.010924294,-0.06604643,-0.055936217,-0.07459081,0.0812524,0.05162972,-0.056129232,0.037996393,-0.006159052,-0.043088723,-0.08593141,-0.009173567,0.017211985,0.05787541,-0.0631119,-0.07359842,0.016975548,-0.08532992,-0.031562697,-0.0075367126,0.0435092,-0.002065672,0.014285715,-0.059397582,-0.0052263504,-0.07023588,0.012335697,-0.03443494,0.06084666,-0.09983778,-0.038165938,0.014513192,-0.030184856,0.015966648,0.007192747,-0.024093864,0.041422643,0.035320666,-0.09405805,-0.012248295,-0.0068789865,-0.0023144786,-0.051122557,0.1087816,-0.054382544 +4.2.3.45,The adjacent gene PaDC2 codes EC 5.5.1.12 copalyl diphosphate synthase.,384,1.0,-0.120530784,-0.10637097,-0.059680853,-0.05185883,0.038537774,-0.0017121834,-0.074479006,0.033889525,0.030290138,0.03638641,0.06348998,-0.01821841,-0.07650361,-0.09553103,-0.059192393,0.014276867,-0.058760665,0.015207345,0.043240726,-0.06294512,0.086441696,0.07762776,0.023088684,0.0066819345,-0.032636117,0.08388067,0.023978496,0.10415912,0.036879834,-0.049442194,-0.016321614,0.047565203,0.007559761,-0.0407386,0.06360762,0.041149795,-0.03710585,-0.10463755,0.01126168,0.04817098,0.07854224,-0.015456583,-0.021981923,0.0042709266,0.0006569569,-0.0076841363,-0.0044266726,-0.037642434,0.03335671,-0.020830503,-0.0022884023,-0.030090624,-0.04184478,-0.043699775,0.01557157,-0.04405205,-0.05617781,-0.024090579,0.032788333,0.0361017,-0.0018238147,0.035697915,0.01219235,-0.07092103,0.065309346,-0.008924467,0.023212131,-0.016547052,0.047658436,-0.041467655,-0.14635472,-0.024546992,0.042853683,0.07744944,0.0052512255,0.09618256,-0.035245314,0.00043400205,0.071750425,-0.08700386,-0.024086207,-0.052897543,-0.036753066,0.021483911,-0.016640654,-0.023319544,0.11068058,0.05102402,0.042421587,-0.006718108,0.054714296,-0.036175348,0.06746588,-0.011112837,-0.07637916,0.04127034,0.015689762,0.054891095,-0.038754873,-0.0575987,-0.0022082124,0.099345826,-0.03781048,-0.06810989,-0.008987432,-0.03164792,0.041057285,0.07790686,0.033147797,-0.014500603,-0.039838016,0.0076305936,-0.0044020247,-0.022871297,-0.0014493181,0.06473789,-0.04600195,-0.0015790605,0.053538177,-0.011695767,0.009910477,-0.062768415,-0.06182287,0.07374754,-0.06398075,0.009998866,-0.111844696,9.240709e-34,0.044124838,0.08240687,0.06589547,0.071494535,-0.07649713,0.0063433107,-0.100711055,-0.003961787,-0.010908939,-0.03026662,0.018351303,-0.13326477,0.048210643,0.042925455,-0.03595417,-0.05332228,-0.05454263,-0.054942194,0.047485735,-0.015719287,-0.020260537,0.064286135,0.0037637884,-0.008205043,0.063565634,0.033684872,-0.12140437,-0.024458583,0.1448047,0.025972797,-0.00037291634,-0.08837575,-0.041328285,-0.021411154,0.053405013,-0.0290016,0.073735885,-0.075077154,-0.0057883463,0.07363824,-0.01195295,-0.0182179,0.025883898,-0.029011339,0.08147099,-0.06873829,-0.030840356,0.071500115,0.02107561,-0.00827761,-0.01953668,-0.03006845,0.08113329,-0.025588091,-0.006302723,-0.032152507,-0.043579973,-0.043555625,0.0026722455,0.14174226,0.03299437,0.055443786,0.0032886094,-0.03619798,-0.004800735,0.009219313,-0.07719679,-0.07076678,0.034097847,0.10717274,0.041728772,-0.024396388,0.0344426,0.039307676,-0.029629406,-0.04247908,0.007942993,-0.00045462477,-0.026086524,0.03210008,-0.026890298,-0.015946548,-0.08356268,0.052683227,-0.03477685,-0.023563564,0.025923638,-0.020721195,-0.052928396,0.06010538,0.06260795,-0.07492096,0.038332887,-0.015386659,-0.027354956,-2.3968075e-33,0.055879578,-0.0061616064,0.003168126,-0.08189448,-0.12011158,-0.0019629996,0.08512124,-0.039042108,0.04772807,0.010785098,0.07339116,0.008435613,0.06806229,-0.0953269,-0.032147463,0.025215264,-0.07079979,0.08583202,0.032173134,0.06587444,0.06821338,0.041592844,0.14406858,0.07596086,0.024437819,0.010676052,0.05058785,0.0882598,-0.035589214,0.013345944,-0.02362684,0.012886126,-0.07350419,-0.027024003,-0.08058027,-0.04543841,-0.0062152618,-0.027590789,-0.035124775,-0.032158583,-0.03905057,0.06995771,-0.04256745,0.06687568,0.009912318,-0.017391324,0.054503456,0.06819549,0.013612327,-0.04412308,0.00670019,0.0095276,-0.038308304,0.040715996,-0.041113604,0.008945719,-0.007612402,0.053992942,0.016453963,-0.016302736,0.0018460805,-0.05420397,0.029020261,-0.045119084,0.08839624,0.030464746,0.026294414,0.095290005,0.043061227,-0.03116558,0.015287739,-0.031143557,0.01728036,-0.022452906,0.009011644,-0.021409014,-0.06738287,-0.00043790796,0.018502055,-0.057031147,-0.03508412,0.007771069,-0.010179652,-0.031459164,-0.020419408,0.041541774,0.049846508,0.10851778,0.030221168,0.016113032,-0.037258115,-0.0218208,-0.009307579,0.114118695,0.036862135,-2.4788875e-08,0.0340134,-0.028516678,0.06381534,-0.045976784,0.060201447,0.042327933,-0.047344107,0.013180945,0.05831703,0.08424247,0.0082580475,0.045363124,0.0033106054,-0.0049425904,0.030799381,0.07104047,-0.067427106,0.08104042,-0.0032440487,-0.035782017,-0.03945774,-0.036051545,-0.015965493,0.048997775,-0.021548312,-0.062444054,0.054639302,0.022520186,-0.0012699713,-0.030062718,0.027272906,-0.06307848,0.02929957,-0.10731381,-0.0038850754,0.019867942,-0.010049658,-0.021416895,-0.058088608,0.03755571,-0.038945854,-0.040337052,-0.057115648,0.0013135228,0.018679127,-0.006817766,0.08356452,0.037690423,0.007343062,-0.04051981,0.025854567,-0.049541034,0.014930124,-0.096043944,-0.057784215,-0.022431782,-0.116956934,-0.008153735,0.021790348,-0.014128949,-0.026013207,0.07695923,0.04245955,-0.03492558 +4.99.1.8,This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme. ,384,1.0,-0.03152801,0.05079549,0.017012613,-0.032873537,0.08123783,-0.02394378,0.00076687575,0.08816141,-0.0027080271,0.054061163,-0.070465356,-0.0137441205,-0.027573917,-0.019310134,-0.06812121,0.05579043,-0.07390638,0.019423183,-0.02404891,-0.038599078,0.04912523,0.083766185,0.010714757,0.01627797,-0.0147664165,0.022298198,0.0769094,0.010356782,0.00037499785,-0.07460999,-0.023920551,-0.05331282,0.009492946,-0.044460375,-0.01500953,0.050636586,-0.004974535,-0.047745623,-0.016778918,-0.023374729,0.079752006,-0.009490001,-0.10611444,-0.051496025,-0.09234067,-0.086210564,-0.0103417095,-0.015961202,0.009295654,0.041822642,0.03714338,-0.066626266,-0.11030846,0.11725657,0.003991547,-0.018309526,-0.010173405,0.023223916,0.049205493,0.0032720414,-0.03853731,0.05960142,0.0003389863,-0.012813688,0.026464272,-0.06003972,0.049319692,-0.0049936417,-0.0987767,-0.06754761,0.021043213,-0.06179307,-0.048081554,-0.0032890528,-0.084648184,0.05354725,0.048702244,-0.036016583,-0.0057765064,0.07579809,0.015600693,0.07459317,0.115913965,0.08276623,0.022935446,0.023644654,-0.09240483,-0.0076899473,0.020223591,-0.043101396,-0.0149372,0.022963027,0.03489014,-0.011476178,-0.01968837,0.05604636,0.047914255,0.10003334,0.05128503,0.0064985263,0.0007404222,-0.008857078,-0.065242656,-0.06561229,-0.07190508,0.025359254,0.0194374,0.036227103,0.09387612,-0.05061462,-0.004648109,0.025107248,0.058714595,0.02604565,-0.048728656,0.05151777,-0.021227593,-0.050871786,-0.06469614,0.015702393,-0.028865963,-0.0077512884,0.02602074,-0.050906308,0.07061502,-0.03747709,-0.04994041,2.5383158e-33,0.010803165,0.03187381,0.09554344,0.0030766795,-0.008191999,0.017882545,-0.064142555,0.07165649,0.035639234,-0.008342618,-0.098662525,-0.07991242,-0.020818582,-0.04076284,-0.0125717735,-0.06034231,0.045939982,-0.0354542,0.024731003,0.016993843,0.015052453,-0.05036945,-0.031452995,-0.04084548,0.025982235,0.0911711,-0.027355522,-0.024095617,0.07360091,0.021821612,-0.04000688,-0.02971756,-0.06521935,-0.029616866,-0.03696473,-0.03968338,-0.050562102,0.0023433312,-0.07155046,0.014971145,0.028197072,0.022065192,-0.043568272,-0.03997449,0.08014174,-0.08746244,-0.04749216,-0.026059972,0.045429982,0.043147344,-0.026246307,-0.015177569,0.13528354,0.017135845,-0.023734199,-0.0033759782,0.0007876295,-0.01906216,0.07626882,0.03768683,0.12407646,0.045999147,-0.051441338,0.04002879,0.05637343,0.042964492,-0.07279372,-0.028459314,-0.00049457327,0.01624023,-0.033250984,0.03852369,-0.08154315,-0.027719991,0.005647066,-0.10852374,-0.029200356,0.037831668,0.07455871,-0.06566347,0.05373488,-0.06641225,0.011675008,-0.04042191,-0.05205914,-0.01861917,0.007443341,-0.016222369,-0.05178784,0.021789879,0.10298434,-0.09094923,-0.09483335,-0.06973984,-0.038718183,-2.3758432e-33,0.09369719,-0.055114355,0.021493461,-0.10189732,0.015918722,0.09767272,-0.040322814,0.06746575,-0.033701528,0.020329252,0.03270041,0.005076962,-0.014239926,-0.018689524,0.002424129,0.02458597,0.013605922,-0.012659198,-0.020781254,-0.057389162,-0.030123895,0.030041693,0.011517333,0.0012549354,-0.026590448,-0.017914813,-0.03382522,0.045509804,0.07703511,0.07270512,-0.037363872,0.06128331,-0.03598973,0.002760857,0.016128078,-0.026676629,0.052697964,0.056604013,0.038510054,-0.030881215,-0.023124076,-0.0020057221,0.055931844,0.11737642,0.090782695,0.14134154,-0.14867447,0.010137615,0.005342675,-0.04291128,0.021527437,0.0417012,-0.04564912,-0.02556943,0.038473893,-0.09263826,-0.058305223,-0.062356967,-0.0015615114,-0.045072217,0.009510861,-0.0070748786,-0.07230896,0.07087645,0.044247665,0.0589099,-0.07293007,0.08195322,-0.017344989,0.00903858,0.033744,-0.02642571,-0.038359236,-0.02560763,0.0137796765,0.014875943,0.016406583,-0.030742383,0.07900484,-0.015537452,0.018387936,-0.014450447,0.014310298,-0.09104145,0.02557529,-0.033005234,-0.003109817,0.077885725,-0.097141564,-0.003314622,-0.070630334,-0.056622643,-0.02322478,0.07662691,0.05466716,-2.5707635e-08,0.02061201,-0.07842362,0.030885302,-0.0010980681,-0.027780423,0.038705535,0.033387974,0.077144176,0.11010841,0.018311772,-0.09277654,0.016703533,0.0705059,0.015919087,0.056768175,0.07714318,0.025003875,0.05730899,0.0010360182,0.023670906,-0.0067820516,0.035727534,-0.022958213,0.075071946,0.046961028,-0.07113094,-0.015563565,0.002910815,-0.0024002267,-0.011510501,-0.051532336,0.081361435,0.021619665,0.017938294,-0.015675178,0.0073150573,-0.0013335577,0.025285346,0.00976192,-0.04173661,0.025798934,0.0002915436,-0.07712263,-0.08718463,0.03297762,-0.00035222742,0.06421232,0.026350679,-0.015085948,-0.07850992,0.04182169,0.011482271,0.009406961,-0.048724454,-0.07441603,-0.069328316,0.03876133,-0.019604202,-0.016268117,-0.07474031,0.08134521,-0.013593626,0.14504467,0.036555696 +6.1.1.27,"In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 (cysteine---tRNA ligase) for the direct Cys-tRNACys formation, Cys-tRNACys is produced by an indirect pathway, in which EC 6.1.1.27 (O-phosphoseryl-tRNA ligase) ligates O-phosphoserine to tRNACys, and EC 2.5.1.73 (O-phospho-L-seryl-tRNA: Cys-tRNA synthase) converts the produced O-phospho-L-seryl-tRNACys to Cys-tRNACys. The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism [1]. Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 (cysteine---tRNA ligase) and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73 (O-phospho-L-seryl-tRNA: Cys-tRNA synthase) [2].",384,1.0,-0.037908368,-0.043784764,-0.07346542,-0.04415002,0.0012352865,-0.025780525,-0.06747794,-0.010347267,0.057289578,0.041260555,0.045195177,-0.07231111,0.0015924545,-0.0032625725,-0.07154443,0.0020901929,-0.10025111,0.028543036,-0.0047680708,0.012700428,0.07949095,0.041781932,-0.058053743,0.031750858,-0.040897124,-0.13936819,0.0006474073,0.007840966,-0.016870666,-0.060819846,-0.065577015,-0.023771936,-0.021620832,-0.06632021,0.014425871,0.06856296,-0.04194593,-0.0293807,0.062486228,0.02223068,0.014380309,-0.008581223,-0.009060212,0.009568896,-0.08749106,-0.027675487,0.040954113,0.01465443,-0.023497269,-0.057258107,-0.07887594,0.0059295255,-0.017058438,0.10025516,0.011862106,0.10390003,-0.1128845,0.011903816,0.007891764,-0.005844016,-0.046843506,0.07093367,-0.020643843,-0.053566694,0.005071064,-0.06519774,0.004386013,0.023530245,0.071836144,-0.0043224487,0.010201398,-0.044549983,-0.0035472135,0.014150605,-0.014864316,0.14687572,-0.023667805,-0.015479549,-0.033715196,-0.027739855,-0.0036286789,-0.0013676847,0.034741733,0.012250015,0.10615237,-0.039550044,-0.044736303,0.07170185,-0.033148926,0.0984102,0.12776905,-0.037853725,0.019334026,-0.055505387,-0.02002619,-0.013182991,0.08118818,0.08834523,0.076392524,-0.050151885,-0.025982445,0.041553125,0.0032600753,-0.06015682,-0.055219825,-0.019655112,0.053729698,0.03151756,0.034119304,0.019952446,-0.055740096,-0.06076347,0.052072927,0.0011781962,-0.035943832,0.07048924,-0.013073411,-0.05429244,0.09275599,0.03508811,-0.028354963,0.02200675,0.037423342,0.07939391,-0.014254036,0.04092996,-0.115080625,2.5231514e-33,-0.010131428,0.07140915,0.021834899,0.023823805,0.056881588,-0.04159982,-0.06394672,-0.02202394,-0.0464808,-0.018782029,-0.12702973,-0.026161872,-0.024841718,-0.046660274,-0.020946274,-0.011384543,-0.057782672,-0.047544558,-0.0011003003,-0.011269716,-0.001239989,0.04598164,-0.025214609,-0.019466368,0.05605599,0.030143503,0.0040162676,0.025200654,0.020636758,0.033712663,-0.017404266,-0.10787043,-0.0489117,-0.009017675,0.024185846,0.024239272,-0.048566833,-0.049731042,-0.09922567,0.019064996,0.024355179,-0.036887348,-0.027949471,-0.0024171208,-0.0019692979,0.016910298,-0.08715991,0.04154736,0.02100934,0.0159301,0.06300708,-0.038059335,0.040715337,-0.010513021,-0.07141488,-0.07307632,-0.05077067,-0.07962183,0.055977292,0.08636986,0.015086741,0.03651376,-0.020068383,0.043349177,-0.011822777,0.039094843,-0.116670735,-0.044189278,-0.037529893,0.02642032,-0.08471145,-0.056069452,0.07585736,-0.03151762,0.054614276,0.0251012,-0.046035744,-0.030363683,-0.015219366,0.025995515,0.01684362,-0.027469024,-0.03226977,0.058776204,0.05969986,-0.015055572,0.0222647,0.06639807,-0.022383504,0.10452514,0.07839131,-0.0798416,-0.00638423,0.065285385,-0.019828824,-4.0762335e-33,0.024786571,-0.025488531,0.09944956,-0.11885897,-0.05286408,0.11404208,-0.011020422,-0.07504417,0.09481965,-0.11410985,0.056477487,-0.012963024,0.009623916,0.012413534,-0.0014608693,-0.097152226,0.0219767,0.07299368,-0.020696232,-0.009421852,0.005031395,-0.0049482984,-0.06275145,0.032169204,0.043824833,-0.021068463,0.04475551,0.11405426,-0.07252193,0.12783247,0.00092985405,0.021756122,0.025726171,0.02290331,-0.05582151,0.0354844,-0.08146784,-0.027424,0.06605638,0.019072903,-0.0029687423,-0.0026797666,0.0026659933,0.05887417,0.021507727,0.07277944,-0.017228477,0.003247588,0.0049184714,0.027057784,0.10373932,0.0047917916,-0.024497626,-0.014720902,0.01995176,0.025390187,-0.015701318,0.035143882,0.019463044,-0.062126882,-0.0453345,-0.030472524,-0.032259718,-0.027055308,0.10177041,0.011087822,-0.031217359,0.068324305,-0.0021669662,0.031830933,0.0045536,0.058474634,0.04187493,0.05880987,0.035257373,-0.00871172,-0.10884148,-0.01578431,0.016836066,-0.008563165,-0.071016654,-0.03034838,0.05377789,-0.058769748,0.018603638,-0.046146862,0.054915834,0.052803315,0.024146648,0.023363907,3.2499327e-05,-0.00149256,-0.010546836,0.02993405,0.03258648,-4.8971106e-08,0.047194123,-0.0513531,-0.08923294,-0.03959708,-0.023533748,0.02930028,0.013303942,0.070954405,0.022192942,0.0072908555,0.044392433,0.047079604,0.028888699,0.03202589,0.048791558,0.011936735,-0.028444009,0.05919345,0.019443553,-0.007933235,-0.06636879,0.021379663,-0.0795194,0.07501091,0.04699628,-0.076014556,0.028638987,0.047199808,-0.056025207,-0.05912366,0.07471079,-0.026996164,-0.033680055,0.040297676,-0.1238609,0.043431062,-0.06594277,-0.03992683,-0.05080098,0.03641787,0.039564807,0.002237043,-0.06975708,0.0034484856,0.011833163,-0.024513794,0.025590392,0.09208081,-0.034326248,0.015951084,0.035393544,0.026016038,0.06447636,-0.051980354,-0.029843371,-0.072651364,0.017026117,0.0032194268,-0.045993086,-0.030779658,0.021403298,0.051751837,0.17064765,-0.057415564 +6.2.1.36,"Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.",384,1.0,-0.036582384,-0.05076446,-0.032757144,-0.013512496,0.03107175,0.027720172,-0.10592919,-0.03586285,-0.051823184,-0.012995386,0.008872142,-0.1439616,-0.050027613,-0.013219364,-0.09252347,0.009552177,-0.02786282,0.0058431756,0.059801634,-0.007669363,0.086583875,0.03346899,-0.086841315,-0.0030746455,0.031852957,0.05487562,-0.007055345,-0.085755035,-0.025968673,-0.06535697,-0.025844196,-0.039752252,0.0077217664,-0.05657697,0.0773856,0.066500425,-0.01960361,-0.034477964,0.0463828,-0.012960029,0.03383763,-0.0075413343,0.03522141,-0.04605973,-0.031597815,-0.0020153301,0.0812187,-0.02754633,0.036853723,-0.06925131,-0.055768143,-0.06584939,-0.07100375,0.001168413,-0.0028879144,0.03652714,0.008453057,0.005671589,0.052476075,-0.0025311455,0.09214799,-0.01259417,-0.015838314,0.016037883,-0.023857478,-0.03625908,0.07646108,-0.033467896,-0.0015918401,0.014283266,-0.06018873,-0.038424935,0.007422017,0.018509423,0.033922937,0.08909528,-0.0036319452,-0.12292034,0.08818446,-0.04413177,-0.03807827,-0.013988299,0.010859541,-0.008409578,0.029484633,-0.037854575,0.009285674,-0.03416543,0.099881634,0.040104546,0.033928134,0.021232108,0.061203815,-0.08453728,-0.048035886,0.05081362,0.036283005,0.089961335,0.08629191,-0.045821533,0.014299703,0.06739707,-0.02759815,-0.15720126,-0.029815368,-0.033777792,-0.033451788,0.1504003,0.12411108,0.053233944,-0.025411513,-0.0431664,0.056621928,-0.0066231065,-0.017895328,0.10677283,-0.012159796,-0.07375197,-0.05779279,0.022566935,-0.023725271,-0.014371078,0.055801455,0.025244975,-0.026477609,-0.013405311,-0.09851536,4.0349986e-33,0.090146326,0.009718846,-0.00093418726,-0.015596728,0.037262954,-0.06287708,-0.12170418,-0.022536362,-0.034005832,-0.046895687,0.0021644537,-0.028145134,0.011876485,0.008149954,-0.039860077,-0.072270036,0.010495624,0.023640266,0.00058071717,0.025604198,-0.039070003,0.016817976,-0.0007815146,-0.0072344188,0.061175726,-0.011558258,0.059790786,0.00804436,0.038828358,0.021232845,-0.0075975317,-0.100228235,-0.09091319,0.0096118115,0.11326696,-0.068728454,0.015199147,-0.049113862,-0.10108262,0.018793952,-0.002373475,0.077502854,-0.009034688,-0.038086973,0.06162384,-0.0505334,0.0035406477,0.15485182,0.0026689975,0.02867666,-0.013289135,-0.0022681092,0.070598595,0.0034655973,-0.06636208,0.025154758,-0.053470187,0.0005767843,0.08694426,-0.03205496,0.00050574733,0.092877135,-0.004088372,0.042333785,-0.03635442,0.082375154,0.0044961935,0.035775013,0.050991505,0.050194178,-0.04764308,-0.03818736,0.015873939,0.07255738,0.00932807,-0.06941753,-0.05790302,-0.07599279,0.030564966,0.0071729287,-0.018737111,-0.001382308,0.040419832,0.0035310665,-0.019652346,0.007792276,-0.045708876,0.07721911,0.024134116,0.06317879,0.10150619,-0.054236084,0.015431883,0.034831688,-0.02121801,-4.8939287e-33,0.064135775,-0.12898134,0.007175325,-0.098573826,-0.08225557,0.0542231,0.048422597,-0.02522459,0.043283787,-0.07194242,0.09777765,0.0025559708,0.047001548,-0.07367822,0.011015037,-0.034189,0.039058007,0.050354782,0.01908478,0.021300953,0.10803733,-0.012561038,-0.053418018,0.058826342,0.038856212,0.025317373,-0.017605228,0.036349017,0.03587826,0.07960986,0.013464424,0.009813556,-0.02099663,-0.09166753,-0.09172066,0.035854273,-0.030957825,-0.0048502106,0.0060470575,0.043158058,0.02823327,0.02907829,-0.036817018,0.095406815,0.03241493,0.01844829,-0.03305035,0.042591818,0.049408082,-0.029234154,0.023912216,-0.08330201,-0.03878505,-0.07855846,0.015234701,0.03306579,0.014238308,0.032883845,-0.069970295,-0.022978788,-0.06944781,-0.064635605,0.0720604,-0.033373363,0.031574383,0.11458436,-0.027172744,-0.009610647,-0.011662607,-0.02302387,0.06848846,-0.03494398,-0.014663387,0.011154426,0.014439563,-0.039334998,0.001433733,-0.023281585,-0.015800571,-0.029228132,-0.020203017,0.02059938,0.058642156,-0.026347429,0.016441263,-0.08268597,0.04400471,0.03893709,-0.07954103,0.04654902,-0.07044756,-0.02493802,-0.014704112,0.04493145,0.02730331,-4.4591957e-08,0.017680535,-0.018949449,0.1180605,-0.025801912,-0.027415982,0.060368665,0.029611912,-0.027653506,0.0712495,-0.07224938,0.015894067,0.04799344,0.072914675,-0.016636895,0.0033743975,-0.0069158743,-0.0006691752,0.027695253,-0.053643968,-0.01897763,-0.027805215,-0.052930634,-0.055437945,-0.007910989,0.025888382,-0.029843856,0.05986038,0.07353625,-0.040586732,-0.060648303,-0.055071935,0.013844478,-0.011015921,-0.008985708,-0.014571577,-0.011260398,0.0011501875,-0.043911897,-0.03672926,-0.008711488,-0.0054208366,0.016589645,-0.08170831,0.036055572,0.03134604,0.038822953,-0.01741241,0.08392486,-0.056951053,-0.0068602283,0.0760694,-0.021014124,0.033808343,-0.054304224,-0.0015155195,-0.0004918531,0.059092674,-0.053559702,-0.06883803,0.031864002,0.03890679,-0.04255881,0.13101088,-0.070554554 +6.3.1.13,"This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes. Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics. The enzyme may represent a novel target for new classes of antituberculars [2].",384,1.0,-0.026408575,-0.014578862,-0.08864295,-0.0375183,0.090780176,-0.028254736,-0.015903769,0.13919058,-0.00403795,0.058023367,0.012184047,-0.073201604,0.039271295,0.034567695,-0.08409566,0.062456507,-0.023533091,0.035337944,-0.022216257,-0.054106686,-0.007925184,0.114473976,0.0005456115,0.013648937,0.015835702,-0.023305867,-0.004491212,0.044276454,-0.06620942,-0.10058898,-0.07167811,-0.06108548,0.06792579,-0.066392586,0.03641997,0.07153827,-0.1175174,-0.059126247,0.0922759,-0.06324672,0.023756806,-0.058649328,-0.0129181035,0.0070822164,-0.008781491,0.00081798143,-0.015019767,0.06993358,0.03852409,0.022728208,-0.088056676,-0.006247522,-0.033875346,0.05636443,0.026889263,0.070714824,0.01238194,-0.038903166,-0.049841292,0.049321275,0.046270873,-0.018292878,0.017215637,0.008652274,-0.058069564,0.0029823778,-0.049292035,0.0023991624,0.07293447,-0.04444452,-0.042501103,-0.08076747,-0.022728154,0.06374836,0.01508303,-0.03542361,0.010515064,-0.009826825,0.013923709,0.02537277,0.0024958702,-0.04916362,0.04543088,0.016403629,0.06843621,-0.0076234504,0.11998821,-0.02934055,0.020857092,0.07163929,0.06269909,-0.028344067,0.008987216,-0.056323204,-0.051382992,-0.014115167,0.07040104,0.020026643,-0.033970445,-0.04482038,0.06565704,-0.046902295,-0.047827918,-0.03905859,-0.080128334,-0.0027244317,0.0046667894,0.005438071,0.041781623,-0.022064574,0.033946563,-0.029934615,-0.029222574,-0.00013156018,-0.03367413,0.06714923,0.12841362,-0.025886873,-0.0752078,0.032325182,0.0047388044,-0.011915793,-0.0040961094,-0.03448449,-0.099605806,-0.024253119,-0.09322735,1.7959708e-33,-0.030443085,-0.010545988,-0.052525226,-0.07627887,0.08786343,-0.03968738,-0.06307363,0.025097162,-0.036763486,-0.056591168,-0.079544134,-0.07746408,-0.019893972,0.046964258,-0.08634597,-0.0014433604,-0.042648286,-0.010747174,0.082592055,0.08386336,0.022726651,-0.013098128,-0.06462375,0.01781847,0.024762845,0.033991173,-0.05657748,0.022459812,0.030084215,0.01360728,-0.0067417794,-0.08228964,-0.082750924,0.004150811,0.039639384,-0.058856383,-0.03693919,-0.06488772,0.013608071,0.031106068,-0.052907612,0.034486894,0.0011158165,-0.023676552,0.06365632,-0.018139506,-0.040554326,0.053400833,0.019290015,0.024781972,0.08610026,-0.07507142,0.06667911,-0.01768657,-0.0025796748,0.002581554,-0.057066724,0.057882942,0.007017063,0.055638354,-0.010905626,0.066896655,-0.03982973,0.089354984,-0.0569145,-0.04381385,-0.027255947,0.0072226706,0.020762779,0.029995482,-0.031480726,0.05050383,-0.0063308133,-0.035479862,0.052349202,-0.040865164,-0.09397679,0.0075060423,0.025365008,0.0008510082,0.06861958,-0.0038834908,0.011120485,-0.035121825,-0.017646281,-0.012645315,0.00027779752,-0.0052367747,0.008683265,0.005515208,0.05878643,-0.044394456,-0.10066459,0.071189396,0.0048229606,-4.149888e-33,0.09925797,-0.107083544,0.13804282,-0.024727901,-0.04670306,0.0786012,-0.015557439,-0.011148739,0.090676434,0.011137738,0.0577118,0.019145668,0.0086432565,-0.026258249,0.02721259,-0.0067206165,-0.040128022,0.013952269,0.008415332,-0.025982808,-0.029410297,0.06479424,0.011328624,-0.01882096,0.020258144,-0.022049692,-0.034231573,0.018587215,0.063992254,0.10262604,0.00069752045,-0.012506811,0.0011701639,-0.077636145,-0.014347101,0.03291302,-0.040750045,-0.025527935,0.06261994,-0.008898241,0.009073328,0.048606373,0.010467562,0.0035251628,-0.055705696,0.06260059,-0.09819357,0.03153088,-0.03886107,-0.11007713,-0.0006727667,0.0021002847,0.038298607,-0.025898742,0.014687714,-0.029086664,0.012130627,-0.02760534,0.04452031,-0.0135579705,-0.047841165,-0.09003532,-0.03456375,0.03221963,0.020534765,0.062070534,-0.018492728,0.07752565,0.08644545,-0.039661128,0.081483476,0.022164427,-0.02911057,0.064858824,-0.0056662713,-0.01916644,0.035118513,0.039854784,0.03752992,0.03082636,0.022516752,0.05411637,0.009800164,-0.13726197,-0.051309645,-0.11562979,0.052391704,0.15128951,-0.04549932,0.085553445,0.021608591,0.09592,-0.09955542,0.009395679,0.08460906,-3.9111292e-08,0.049729858,-0.062001705,0.054959297,-0.036981378,0.017501362,-0.0035367296,0.0052157375,0.015188528,0.08223607,0.019361926,0.024283668,0.096018836,0.050691143,-0.019576203,0.055661224,0.032695368,0.007108084,-0.04697335,0.008393926,0.045089167,-0.05414399,-0.0005903597,-0.06993366,-0.046654962,0.042747296,-0.039030433,0.012251778,-0.03890197,-0.0624648,0.028738681,-0.026208036,0.022856168,-0.03781992,-0.02832028,-0.10906482,0.0292263,-0.078723945,-0.09996398,-0.00039790012,-0.020303598,0.016274303,-0.069927454,-0.033883277,-0.011488259,-0.049313344,-0.007411116,0.010112048,-0.0045988047,-0.0043489505,-0.013849843,0.020351749,-0.01637949,0.045652896,-0.019004475,-0.052989032,0.088252194,0.041118827,0.008483193,-0.069099784,-0.071690895,0.020615596,0.011768652,0.16048788,-0.027559351 +1.1.5.5,"Only described in acetic acid bacteria where it is involved in acetic acid production. Associated with membrane. Electron acceptor is membrane ubiquinone. A model structure suggests that, like all other quinoprotein alcohol dehydrogenases, the catalytic subunit has an 8-bladed β€˜propeller’ structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ; the catalytic subunit also has a heme c in the C-terminal domain. The enzyme has two additional subunits, one of which contains three molecules of heme c. It does not require amines for activation. It has a restricted substrate specificity, oxidizing a few primary alcohols (C2 to C6), but not methanol, secondary alcohols and some aldehydes. It is assayed with phenazine methosulfate or with ferricyanide.",384,0.99999994,-0.06568471,-0.0547406,-0.12790158,-0.04210401,0.034372468,0.019212168,-0.0255747,0.022499252,0.047724713,-0.02874791,0.012522982,-0.051221088,-0.097659804,0.06923131,-0.05070454,0.0035511088,-0.056719773,-0.07433666,0.024364999,-0.04634952,0.007821736,0.0054229894,-0.041452218,-0.09373168,0.033512473,0.024803951,0.062339235,0.06596938,-0.052759614,-0.07056314,0.02957076,-0.05011577,0.07817647,-0.029733395,0.033800244,0.05076442,-0.06084461,-0.051009323,0.075411886,0.002219941,0.031140756,0.020861413,-0.044173546,0.031718004,0.021483764,0.024139944,-0.055581495,0.091372214,0.014642999,0.007219577,-0.013706099,0.01714926,0.06149668,0.07562788,0.04561159,0.018153882,-0.009259236,0.0087105725,0.010798823,0.04106618,0.00889834,0.021478796,0.012562288,0.020082345,-0.022246271,-0.0459842,0.0014629094,-0.04604418,0.06563788,-0.03813854,-0.04001973,-0.08917182,-0.01696648,-0.03354102,-0.0047636847,0.027073726,-0.004376751,-0.016432047,-0.011068239,-0.04001666,-0.002834148,0.0016806022,0.0035610904,0.10350988,0.0966273,0.017472984,0.00045953505,-0.06323725,0.025414778,0.04461876,-0.0037174087,-0.0333354,-0.044368453,-0.10296999,-0.033824127,0.04558776,0.12185064,0.020518443,-0.030603472,0.0048521804,0.016249564,0.042513374,-0.021414457,-0.12969069,-0.07044899,0.015048924,0.06865679,0.11700657,-0.0019154707,-0.019396503,-0.0010507345,-0.004978036,0.06638814,-0.048466142,0.06897607,0.010587005,0.095542416,-0.0981037,-0.013670133,-0.039986707,-0.059810057,-0.020201033,0.06618091,-0.012653301,0.020409862,-0.0158291,-0.10430166,2.8721625e-33,0.03357508,0.04168413,-0.048106857,-0.03232107,-0.021552643,-0.0432012,-0.047983278,0.045891117,-0.054263186,-0.022432623,-0.03002731,-0.07695446,0.02457812,0.011439906,0.010776191,0.03281722,0.00792598,-0.055340026,0.05886758,-0.030871678,-0.024589583,-0.03577367,-0.0632144,-0.022422006,0.07188486,0.008274634,-0.023838654,0.00872451,0.015924267,-0.008239617,0.009936495,-0.02508508,-0.055122446,0.020354431,-0.040453017,0.050849535,-0.099541955,0.042033594,-0.047579996,-0.019744974,0.06894423,0.076056756,-7.4945725e-05,0.003387015,0.023780586,-0.016178519,-0.048860613,0.08906555,0.043639667,-0.01426957,0.03858094,0.007707471,0.13466768,-0.09964132,-0.08052191,0.06437097,0.0009861002,0.011759694,0.03897993,0.022551,0.0680262,0.037794787,-0.13239066,0.052559327,-0.020484146,0.015109583,-0.054051913,-0.07094985,0.06323627,0.06367174,-0.08472211,-0.042561106,0.08576943,0.016298313,-0.014379669,-0.0041247457,-0.055894982,-0.002377189,0.08122031,-0.017655075,0.023639793,-0.024299448,0.06365373,-0.01027125,-0.022402119,-0.05114252,-0.0011597979,-0.059680607,-0.05281946,-0.0012946433,0.08403294,-0.061789393,-0.07725989,0.04422953,0.035174716,-5.011931e-33,0.0925412,-0.09897131,0.06305001,-0.103818595,-0.019417586,0.12154265,-0.0076493146,-0.006753689,0.0107791545,-0.07111682,0.108284555,0.010193426,0.0024233558,0.0019605267,0.06189067,0.0030297951,-0.035172377,0.03858564,0.040399123,0.0033095868,0.032295067,0.059228048,0.018240679,-0.027353227,0.020585515,0.010901152,-0.048919167,-0.020435022,0.053879425,0.035370078,-0.034066003,-0.0027904161,-0.019536536,-0.020459274,-0.04156896,0.031626213,-0.06647382,0.0004997794,-0.00933596,0.04182071,0.04657362,-0.036499728,-0.019878462,0.031569287,0.052563515,0.09388195,-0.045108426,-0.02589418,-0.10374824,-0.034896996,0.0631383,0.01975951,-0.085199066,0.055711966,0.05976234,0.10652002,0.0063755326,-0.0650017,0.0102774585,-0.035809886,-0.06590674,-0.025019094,0.0015701768,0.0011428158,-0.049930613,0.03200739,-0.020323904,0.09833379,0.0050531975,-0.06923194,0.026359936,0.0034789403,-0.016758524,0.033449646,-0.06296856,-0.032618903,-0.08132472,-0.04898707,-0.0049304077,0.031663742,0.0049010874,0.0034843415,-0.044922344,0.04069628,0.027835129,-0.050777886,0.056400277,0.03743248,-0.040534843,0.08473327,0.05344825,0.017834792,-0.063424364,0.058257636,0.025827985,-4.9587634e-08,0.016773151,0.0008684276,0.072065964,-0.05718663,-0.0064813057,0.013596608,0.05272695,0.00891074,0.008168337,0.00610559,-0.01576189,0.052290354,-0.046990514,0.036221452,0.027211295,0.037188824,-0.047696654,0.0026847322,-0.019955384,-0.03415682,-0.062022846,0.016347725,-0.0792524,0.015037378,0.0048142658,-0.072093345,-0.020471158,-0.01464172,-0.033258043,-0.018106356,-0.028231537,0.09380469,-0.003460183,-0.05845918,-0.049260926,-0.0005099547,-0.009110513,-0.102387264,-0.0514601,0.00082560093,0.06309336,-0.049280472,-0.10843791,0.01911525,0.06097443,0.07876699,0.012367449,0.012699404,-0.064250834,-0.007710056,0.08153073,-0.001669445,0.071400605,-0.06093705,-0.11511481,0.04004919,-0.031548284,-0.079460874,0.00037173234,-0.08562812,0.10532801,0.021850951,0.18159851,0.041934982 +1.1.1.301,This enzyme participates in arabinitol catabolism. The enzyme also converts D-arabinitol 5-phosphate to D-ribulose 5-phosphate at a lower rate [1].,384,1.0,-0.030937703,-0.052204344,-0.020481842,-0.04507982,-0.03158798,-0.0031945913,-0.014273248,-0.009500525,0.04714816,0.059456013,-0.02243769,0.044460617,0.0002798932,0.026920078,-0.06987104,0.026503943,-0.015820181,0.096574485,-0.07794037,-0.06989635,0.09257776,0.051351428,0.028881148,-0.0071175206,0.0699335,-0.02588228,0.03483773,-0.0023936767,-0.046158366,-0.07496287,-0.004500101,-0.009779821,0.045421824,-0.019025858,0.0005303353,0.14630984,-0.014707688,-0.019149322,0.042048074,0.01676048,0.07986821,-0.067189276,0.028198048,-0.049593102,-0.039351486,0.004940193,-0.043264117,0.038832646,0.09344047,0.03469462,-0.065841876,-0.07746334,-0.02605808,-0.09358301,-0.004364798,0.008672673,0.017707676,0.0019972858,-0.06551222,-0.04728825,-0.0053427615,-0.0007428995,-0.0039135027,0.053397015,0.051630143,-0.058897264,0.05972174,-0.0817532,-0.019561308,-0.07313684,-0.03690264,-0.056510944,-0.014965375,0.032930315,-0.03506198,-0.059426934,-0.044144608,-0.03812075,0.024391389,-0.0057451357,0.064994656,0.033274565,-0.006232837,0.041812032,-0.012519729,0.039224833,0.024572575,0.0079953885,0.045698855,0.030986095,0.006917321,-0.0057586604,-0.006487081,-0.024184937,-0.053806998,-0.030637668,-0.019782586,0.045061216,-0.05388726,-0.04298624,0.008452771,0.0359364,-0.016406417,-0.07394249,-0.06738694,0.013145561,-0.019447781,0.06337316,-0.023248494,-0.04264108,0.011059392,0.016329655,-0.026550055,0.0509265,0.010500985,0.12901197,0.04252758,-0.110179886,-0.03548703,-0.027104884,-0.03504266,-0.05397695,0.08582136,0.08782964,-0.099213675,0.06587853,-0.07728382,1.0610909e-33,0.012163032,-0.042352468,0.016701572,0.01504242,-0.052153423,0.009784824,-0.10633592,0.010630477,-0.07171393,-0.056763217,-0.121690534,-0.05148955,0.09563775,0.034376096,-0.015485965,-0.014688544,-0.01833938,-0.025875611,0.07775067,0.044514094,0.06342883,0.072540365,-0.02860716,0.06915539,0.025619,0.053221963,0.021241114,-0.01424871,0.024718778,-0.0019747121,-0.017264098,-0.038600545,-0.07412875,0.008794873,-0.03630791,0.0060679135,-0.055108063,0.03687163,0.008071544,0.06766957,0.01417538,-0.043184448,0.002422299,-0.015662689,0.079864666,-0.0029172061,0.026213054,0.07684825,-0.0009258691,0.08304652,0.10795195,0.0062773316,0.09668024,-0.03219917,-0.08207027,0.05274586,-0.009111481,-0.024774857,-0.034343533,0.09489285,0.0020049806,0.02132376,-0.002787971,0.050829574,0.003785033,0.013815799,-0.011118232,-0.114532314,0.021875655,0.082663804,-0.034888137,-0.019907264,0.10910814,0.064994946,0.035917874,-0.0015397693,-0.0063609057,0.0010917786,-0.0021901568,0.01019756,0.021628601,-0.019810487,-0.0173807,-0.029982489,-0.047775153,0.054444894,0.04420367,-0.11162549,-0.042679425,0.0041546263,0.08797509,-0.060692552,-0.08190241,0.02963646,0.07972568,-2.3830635e-33,0.13106927,-0.09762455,0.0077890554,-0.016972482,-0.07715813,0.005816676,0.08527097,-0.0070692827,0.0388491,0.014346891,0.08635682,-0.028328143,0.009920633,-0.02980482,-0.0101390425,0.006196886,-0.03445046,0.011286687,-0.022542734,0.037489455,0.005676676,0.10168079,0.042887975,0.014545947,0.047655642,0.0039789025,-0.014763999,0.06396574,0.021957085,-0.016897446,0.012991916,0.019952878,-0.03778011,-0.003901815,-0.08825409,0.07953851,-0.0966373,-0.008300255,-0.032111462,0.013999718,-0.069312,0.102779984,0.056132123,-0.0025738834,-0.019866403,0.059999917,-0.028013816,0.0071554645,-0.058367662,-0.12708656,0.024752868,0.04635411,0.036397714,0.08171738,0.032075435,0.06327574,0.02658511,0.05339382,-0.069508255,0.0020710141,-0.02636445,-0.0438118,0.09649578,-0.031474635,0.054011084,0.04447139,-0.008766348,0.028238265,-0.01129379,0.020789063,0.09680116,-0.013105129,-0.01824462,0.041081294,0.009739109,-0.021760881,-0.10826383,-0.002601527,-0.06265773,-0.06491999,-0.061347954,-0.004526967,-0.08970204,-0.06662154,-0.0018964212,-0.10640662,0.019336466,0.10356967,0.03410775,0.06321226,-0.04057327,-0.022231933,-0.043608207,-0.017979953,0.05812725,-2.8505932e-08,0.0022544302,-0.046449963,-0.0046763266,-0.05166167,0.0130512025,0.05486144,0.0029424243,0.04603614,0.025459288,-0.044782054,-0.06292538,0.07336736,-0.005223071,0.07468891,0.028716184,0.050120775,-0.043597754,-0.015491277,0.017753666,-0.045075368,-0.05148898,-0.019471087,-0.14963631,0.016312499,-0.032039654,-0.027865632,0.012699619,0.057121973,0.026274474,-0.040427066,0.010216133,0.0178026,0.005611443,-0.113190606,-0.04349211,0.06517007,-0.033599887,0.011073266,0.0115014,0.040291473,0.010632419,-0.0809303,-0.030415721,0.0035893011,-0.042802103,-0.034872502,-0.018981377,-0.0064675747,0.032993753,0.06498721,0.10061065,0.02808384,-0.05969835,-0.057447612,-0.056713358,0.011760178,-0.026187554,-0.10608983,0.042104676,0.01601848,0.00013660936,-0.01133418,0.12110604,-0.07271763 +1.1.5.6,"The enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups. Formate dehydrogenase-N oxidizes formate in the periplasm, transferring electrons via the menaquinone pool in the cytoplasmic membrane to a dissimilatory nitrate reductase (EC 1.7.5.1), which transfers electrons to nitrate in the cytoplasm. The system generates proton motive force under anaerobic conditions [3].",384,1.0,-0.079030104,-0.049334582,-0.12967189,-0.024951616,0.057360448,-0.0019571078,-0.05344399,-0.01216072,-0.005237102,-0.049931873,-3.5896646e-05,-0.049444508,-0.08339195,0.003019277,-0.10264592,0.013563733,-0.049940992,-0.012275921,0.014547281,-0.05325658,0.03471429,-0.023157049,0.023035292,-0.06344602,0.015146648,-0.0011367026,0.014144213,-0.0251364,-0.056199178,-0.110519476,0.032238115,-0.03308277,0.07067742,-0.026463771,0.0465149,0.15549892,-0.010812263,-0.01890297,0.032560192,0.08037806,0.029964723,0.024847984,-0.008632097,-0.0041968105,0.026393661,0.022848645,-0.0039581764,0.0445724,0.0016114349,0.013817776,-0.005249734,-0.07143327,0.0045175934,-0.019739067,0.018343395,-0.013565386,-0.018769143,0.028127199,-0.00968114,0.016037725,0.061735675,0.020852193,0.043483626,-0.0049924934,0.067511395,-0.034324523,0.109502375,-0.04404005,0.007001001,-0.11128411,-0.02545144,0.013361191,-0.04301033,-0.07319699,-0.09411766,0.044751886,-0.008950357,-0.010880327,0.049027026,-0.042651925,0.01446259,0.06144398,0.010533006,0.091854505,0.050683487,0.009064243,-0.022061478,-0.023762234,0.0006433831,0.029273087,-0.005788852,0.037371,-0.039211944,-0.0056688967,-0.10358959,0.05009206,0.012465941,0.05188306,-0.011236687,-0.023146534,0.014653443,0.12629662,-0.0232033,-0.03621327,-0.07153239,-0.0004141389,0.016628299,0.078260146,0.018758057,0.08475735,0.008842677,0.056268357,0.024727656,0.0074561555,0.03647862,0.030186199,-0.027358804,-0.008569708,-0.023823941,0.044818744,-0.008618966,-0.014209617,-0.057223104,0.050736833,-0.01478638,0.012823459,-0.084146746,7.1075854e-33,0.07315467,-0.008708282,0.032327347,-0.010878913,0.019822102,-0.008590163,-0.07301169,0.017089305,-0.034927994,0.0018438094,-0.040209774,-0.06304918,0.10676755,-0.05062118,-0.017556796,-0.046104264,-0.00408109,-0.037664883,0.011406968,0.04723641,0.027829643,0.058179405,-0.06504368,-0.034159023,0.055622652,0.05656031,-0.036458775,-0.023612449,0.0651421,-0.013237061,-0.033108175,-0.1252473,-0.0767785,-0.037776098,0.04286295,-0.052459996,-0.06874434,-0.015452451,-0.0053061927,0.07464623,-0.07559046,0.05348366,-0.0131378565,-0.044951357,0.086322114,0.015718065,-0.007844892,0.0725367,0.03708877,0.03401036,0.021278415,-0.056980316,0.1004717,-0.07291007,-0.02781498,0.008204897,-0.04213506,0.0168264,0.027283382,0.06933655,0.0688651,0.031187376,-0.0398416,-0.023503728,0.05166512,-0.028323084,-0.04634565,-0.056427196,0.06565528,0.06687241,-0.09287825,-0.017356424,0.05865571,-0.0021120978,-0.043418877,-0.016620968,-0.038349647,-0.024323849,0.056326758,-0.036851212,0.022796884,-0.0067648934,0.025080357,-0.087656625,0.007462341,0.024805315,-0.0041198637,-0.05227338,0.014010388,0.017480893,0.07781077,-0.10701173,-0.05263956,-0.07467863,0.055622548,-6.654487e-33,0.12888065,-0.014879728,-0.013324753,-0.10181614,-0.051310435,0.099210456,-0.002886465,-0.0073482413,0.035088103,0.034525875,0.03138414,-0.01634233,-0.0028066898,-0.060245287,0.053438433,0.0016650339,-0.057668474,0.11205336,-0.0057859295,0.009340918,0.017486556,0.09725118,0.039632898,0.043473717,0.102567635,0.012949744,-0.032343596,0.03461876,0.061253335,0.042437673,-0.05027487,-0.03895526,-0.059222065,-0.015050306,0.012281319,0.019299647,-0.09234893,0.05950595,0.028165273,-0.0059251566,-0.034023672,0.07878188,0.061756745,0.11012632,-0.00027523088,0.07218313,-0.13268948,0.015732192,0.009067157,-0.0156493,0.013102799,-0.027739221,-0.08380132,0.018330652,0.03070372,0.027588107,0.03452463,0.013690997,-0.015589704,-0.015500936,-0.04432682,-0.10980706,0.037656233,-0.012282947,0.0048955143,0.021352604,-0.015928455,0.073820144,0.07185849,-0.016084503,-0.011838036,0.015652163,0.056719862,0.043008313,-0.06433225,-0.02120564,-0.024534272,-0.0043192836,-0.00494657,-0.04607056,-0.012183514,0.04481518,-0.053066958,-0.09225495,0.058579355,-0.06372183,0.08883381,0.09888396,-0.006969613,0.029532783,0.017688302,-0.03471095,0.017857278,0.03527933,-0.010344802,-4.8318967e-08,0.058907606,-0.057413906,0.092277616,-0.03616617,0.034078125,0.04264402,0.0036800585,-0.022194013,0.022136852,0.0014712707,0.07027235,0.07312632,0.0069675394,-0.036282357,0.06579488,0.08432052,-0.018230924,0.004621184,-0.03574437,-0.014360187,-0.03663378,-0.027081888,-0.20939068,0.10092743,0.030067122,-0.011045799,0.05502872,0.004568028,0.017603232,-0.015545914,0.0056171673,-0.0031508238,0.067838214,-0.056548323,-0.04761483,0.008383737,-0.013087336,0.00012433104,-0.036339987,-0.025035478,-0.040563975,-0.060172275,-0.022049556,-0.004996434,-0.030548653,-0.00090513955,-0.040250722,0.033367887,-0.039951824,0.08670231,0.023655038,-0.07773858,-0.0017475608,-0.014994801,-0.102414995,0.027027296,-0.043123282,-0.092525385,-0.0006960913,-0.048115227,0.040137835,-0.010168018,0.17132854,-0.0240578 +1.1.5.7,"This enzyme oxidizes a wide variety of cyclic alcohols. Some minor enzyme activity is found with aliphatic secondary alcohols and sugar alcohols, but not primary alcohols. The enzyme is unable to catalyse the reverse reaction of cyclic ketones or aldehydes to cyclic alcohols. This enzyme differs from EC 1.1.5.5, alcohol dehydrogenase (quinone), which shows activity with ethanol [1].",384,1.0,-0.032244325,-0.009769001,-0.017251678,-0.0297804,0.09158444,-0.007284641,-0.10309371,-0.03685199,0.04332598,0.017069306,0.028777601,-0.040698722,-0.0648366,0.01819675,-0.029580595,0.047190215,-0.078818716,-0.026489038,0.054540955,-0.04824163,-0.012829701,-0.042934652,0.017787172,0.007492387,0.038675398,0.045941107,0.019353487,0.06280795,-0.043357283,-0.09850766,0.027089136,0.02210949,0.014937937,0.0034998783,-0.027113143,0.0717809,-0.07381202,-0.002669479,0.051566638,0.034975078,-0.0025613345,-0.008789764,-0.046595823,-0.061302096,-0.014659516,0.0017810562,-0.051280618,0.043036256,-0.02636771,0.010248515,0.017292477,-0.054263476,0.037300743,0.031399112,0.07049762,-0.006852843,-0.028872307,0.029998966,-0.0031965016,0.06956247,0.08839263,0.029483521,-0.04992412,0.03933085,-0.049358066,-0.044769697,0.038538404,-0.067407444,0.016254263,-0.11287263,-0.040242493,-0.14552215,0.015913932,0.02214283,-0.016715711,-0.012347543,-0.030857299,-0.037225425,-0.0014526714,-0.051593084,-0.007436202,-0.009371768,0.04722226,0.055666115,0.069269694,-0.004864899,-0.003182558,-0.02426465,0.0017279243,0.06671355,-0.0053549367,0.009090758,-0.0041054115,-0.11465492,0.0038318513,0.08278206,0.0270933,0.06896878,0.015779061,0.0017573959,0.0338273,0.09633513,-0.047201466,-0.105307855,-0.050714575,0.051912498,0.0429332,0.044516582,0.01129226,-0.012385176,-0.03284107,-0.03441417,0.055333026,-0.054132763,-0.009387609,0.11841261,0.028267555,-0.011036095,-0.027824389,0.009452605,-0.0011167693,-0.028609706,0.098305434,0.084558636,-0.016378129,0.09472675,-0.04506261,8.172328e-34,0.019915355,0.0056960424,-0.042001605,-0.062443484,0.0015286043,-0.018478861,-0.0722861,0.11284392,-0.040603444,-0.108140826,-0.022492208,0.02160102,0.07090933,-0.033997696,-0.008822981,-0.016376354,0.012062688,-0.036824234,0.04537433,-0.022371944,-0.0155814765,-0.04350075,-0.08860387,-0.007588868,-0.0010567602,0.04297552,0.059195124,0.021442361,0.028763741,-0.007453231,-0.02966106,-0.006835347,-0.053957555,0.00038721645,0.005636026,0.062131003,-0.024204805,0.05485138,-0.07540378,0.07167885,-0.007947333,0.013018007,0.04121766,-0.063955784,0.0045710313,-0.025700279,0.0029042521,0.124165215,0.07448452,0.006551949,0.07417731,-0.017219897,0.042190824,-0.029670484,-0.07442694,0.13945642,0.009373003,-0.03528972,0.04652895,0.0064339093,0.03475348,0.011509592,-0.0631282,-0.017869962,-0.010175105,0.03398582,-0.09059205,-0.07310385,-0.0065938453,0.060543586,-0.0910117,0.018274276,0.1095724,-0.025609428,0.018978925,0.051910523,-0.04524578,-0.034070067,0.047213618,0.02150656,-0.010004211,-0.06041628,0.08536035,-0.051540174,0.018030517,-0.072503515,-0.06256669,-0.035369188,0.0033703798,0.059112385,0.016277773,-0.07436842,-0.013858205,0.033720274,0.08923937,-2.1741723e-33,0.06614966,-0.041191436,0.009803026,-0.074386485,1.1736599e-05,0.071995415,-0.003688901,-0.03131958,0.0049571805,-0.017228603,0.061112456,-0.026619945,0.04825242,-0.011404992,0.057033647,0.011131832,-0.05693308,0.081816174,0.010541518,0.012179292,0.029624509,0.08762246,0.0074131875,-0.0189622,0.07634629,0.042283174,-0.034435187,0.06354492,0.099737205,0.029336413,-0.034660134,-0.04775125,0.04874237,0.0064491807,0.044795714,0.10379214,-0.09783573,-0.026358483,-0.028189259,0.053335242,-0.061039496,0.0010641637,-0.0033966284,0.013393516,0.0439604,0.07031253,-0.06464068,0.0039888723,-0.026880015,-0.079120375,0.062460814,0.05677202,-0.08985975,0.024612512,0.02151373,0.09007971,0.006753023,0.02540369,-0.023278806,-0.017985545,-0.05677978,-0.009498529,0.064417824,-0.0010618431,-0.036910094,-0.0026901187,-0.10611076,0.08822505,-0.06529399,-0.0024298925,0.06453047,-0.042161886,-0.035953563,0.026770677,-0.01860573,-0.026797878,-0.015692148,-0.027709417,-0.042016707,-0.026162086,0.045142498,-0.0007828326,-0.02929766,-0.018965984,-0.08443264,-0.057104856,0.020261949,0.042081818,-0.040473644,0.050665148,0.0034964962,0.03359138,-0.0693162,0.08701611,0.05528089,-3.2511103e-08,-0.042259686,-0.06342056,0.10964315,0.04585791,0.051689874,0.0026524817,0.07271841,-0.00995462,-0.010086409,-0.080414735,-0.03782785,0.029671347,0.029144183,0.025498172,0.05145825,-0.005524064,-0.03984856,-0.040417906,-0.013413906,0.0040188255,-0.024266131,-0.024969509,-0.061606444,0.0038887677,-0.091177315,-0.028726384,-0.029849669,0.0446332,-0.035179473,-0.0673334,-0.059153564,0.09657956,-0.039986473,-0.026602445,-0.089965664,0.023637872,-0.034663767,-0.017120998,-0.1153604,0.014819487,0.024962468,-0.11291458,-0.10709798,0.0018067397,0.005270214,-0.019711643,0.059464645,-0.027933195,-0.0056972126,0.0457937,0.07214648,0.0025034868,0.02491482,-0.007691805,-0.018579682,0.018461647,-0.035951048,-0.09782275,-0.033807248,-0.078878775,0.029867455,0.029917374,0.21243402,-0.0010311127 +1.1.99.33,"Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1].",384,0.9999999,-0.0324189,0.030093208,-0.073330924,-0.0037589534,0.047629442,0.0020049263,-0.09526018,0.03636477,-0.0020034262,-0.055857748,-0.01593713,-0.02526544,-0.074647315,-0.0014937214,-0.045289487,0.0038743943,-0.10928017,0.002930987,-0.02067973,-0.11005467,0.061898023,0.05611054,-0.03345333,0.012672094,0.031331476,-0.016694754,0.05475579,0.021565445,-0.05124518,-0.08213115,0.009699314,-0.075323395,0.099905066,-0.019667806,0.03409989,0.083487384,0.04786518,-0.072483785,0.04176183,0.023023972,0.046026655,-0.0015446353,-0.03731371,-0.067791305,-0.06130718,-0.018256005,0.040022727,0.012800105,-0.022113943,-0.0014235395,-0.010831104,-0.06166789,-0.0818448,0.018705899,0.009267822,0.052582357,0.036286656,0.03046361,0.0014998568,0.022611957,-0.033005532,0.017719751,0.015830623,0.014741608,0.012132317,-0.031843293,0.09579946,-0.048811562,-0.026554165,-0.119518556,-0.052657943,-0.033479173,-0.07294862,-0.0046301004,-0.09585205,0.019327601,-0.042020753,-0.038613606,0.053214602,0.042365164,0.06130187,0.02000527,0.097750925,0.076334596,0.05605361,-0.015961774,-0.007153113,-0.040548142,0.018313373,-0.040529158,-0.016857497,0.0020020076,-0.07407592,0.011661007,-0.03486884,0.084218025,0.13128829,0.0853003,0.04907784,-0.0021411218,0.0013525202,0.05517141,-0.03480096,-0.06812571,-0.035497714,-0.024177842,0.039455604,0.11855375,-0.033449877,-0.004491099,0.048632413,-0.03429245,0.022098152,0.015436754,-0.012024449,0.062600784,0.017145326,-0.006321479,-0.046769477,0.012381677,0.04225978,0.016038574,0.015701093,0.006380221,0.0083185155,-0.00011447294,-0.06601399,2.92945e-33,0.03828865,0.009599566,0.0004951805,-0.007800925,-0.029794628,0.01021583,-0.120150685,0.055893254,-0.0029453556,0.013000811,-0.04795117,-0.01746015,0.06942759,-0.04988859,-0.029954642,-0.028239833,0.014601874,0.04118356,-0.025960578,0.065898806,0.017593248,0.06492746,-0.014582085,-0.0029129556,0.020717641,0.058914505,0.019606607,-0.041323077,0.057666395,-0.007908475,-0.04538243,-0.122640446,-0.08753429,-0.05019159,0.011695846,0.00401476,-0.05919215,-0.09031473,-0.01568801,0.012818971,-0.06406962,0.03960907,0.018959308,-0.08418178,0.046997923,0.032149207,0.04571137,0.022715025,0.0073646237,0.04778874,-0.007575677,-0.026497042,0.09184795,-0.06703271,-0.05907839,0.03344936,0.0056486367,0.010445624,0.08724965,0.095083326,0.026131108,0.08118325,-0.040310998,0.017705167,-0.007954386,-0.057441335,-0.047140248,-0.07858567,0.03738315,0.038276415,-0.031501755,-0.018026747,0.06476137,-0.0010450374,0.020699652,-0.07407526,-0.009583053,-0.022053955,0.062063362,-0.030576047,0.010216191,-0.037813872,0.056595463,-0.06345589,0.025583953,-0.037883513,-0.06915719,0.047797646,-0.04335401,0.031854168,0.013147862,-0.0935916,0.01612805,-0.064499974,0.052573487,-3.384668e-33,0.055552345,-0.04630811,-0.0029893795,-0.0902704,-0.037108034,0.1174913,0.017838804,0.013257259,0.03849378,0.0007967623,0.054846603,-0.016053803,-0.010305258,-0.10367335,0.031797227,0.027486471,-0.0922844,0.042529088,0.0060305954,-0.017496414,0.052567396,0.058829296,0.08997657,0.036114898,0.100333154,-0.042931803,-0.007567526,0.040567826,0.08002066,0.05831791,-0.032826737,-0.07492601,0.041950766,0.0148266805,-0.029469546,0.03799605,-0.019992655,-0.03221213,0.044678204,0.02321175,-0.037387762,0.03096546,0.047035307,0.12643732,0.0045906575,0.07558686,-0.13960426,0.037122477,0.03328147,-0.0077106752,-0.03533504,-0.03868499,-0.093153864,-0.045331627,-0.043702677,0.013520902,0.008345406,0.036806602,-0.12200357,0.012945809,-0.029472573,-0.054489758,0.05800146,0.08451243,0.018448897,-0.00012247915,0.0037189457,-0.030591773,0.0075478386,-0.0020152188,0.114395365,-0.014218172,-0.0041460684,0.042097546,0.02925932,-0.09383132,-0.04150942,0.024789037,-0.007987307,-0.0044152793,0.027037399,0.015834998,-0.010309551,-0.058161613,0.052728202,-0.09732357,0.033876717,0.1121465,-0.05245213,0.007916309,0.012082432,0.023000794,-0.004397338,0.08071631,-0.0016142298,-3.7981984e-08,0.028513342,-0.09605795,0.11134442,-0.06805894,-0.01765574,0.011278394,0.06585553,-0.014889731,0.04608153,0.019615792,0.0465458,0.026995087,-0.0279166,-0.03557969,0.04161246,0.06304992,-0.019707734,0.033997633,-0.053213935,0.043141082,-0.005054146,-0.019017246,-0.11644215,0.080752805,0.021339284,-0.0077707646,0.035900827,0.073245294,0.03407739,-0.03464141,0.0071868594,0.044047926,0.040135115,0.0065168287,-0.1123589,-0.04224493,-0.00204425,0.04535171,-0.058937024,0.037789535,-0.034211915,-0.032204065,-0.030330746,-0.02394345,0.008851294,-0.0008116224,-0.0008824755,0.044856012,-0.0056028934,0.05168814,0.04654927,-0.020408379,-0.0238415,-0.03720157,-0.09130303,0.013633071,-0.03606423,-0.06537177,0.02274186,-0.051807445,0.08864154,0.012588139,0.20039473,-0.02886602 +1.2.1.77,This enzyme catalyses a step in the aerobic benzoyl-coenzyme A catabolic pathway in Azoarcus evansii and Burkholderia xenovorans. ,384,1.0,-0.015386842,0.0056405263,-0.05299486,0.020880079,0.09486448,0.036995806,-0.082794555,-0.058636766,0.04113347,-0.052321527,0.022751033,-0.09956377,0.01797124,-0.010903023,-0.06846566,0.06436262,-0.09731525,0.029372964,-0.08514844,-0.014989511,0.054591272,0.049838915,0.021162944,0.10404752,-0.004826277,-0.047230903,0.027407551,-0.048415583,-0.02369662,-0.025006972,-0.034403052,-0.0199965,0.08566416,-0.034260456,-0.0037199473,0.07347495,-0.016221106,-0.1302123,0.05731643,0.041688554,0.009752137,-0.012794249,-0.06639874,-0.021410532,-0.09353266,0.0037283073,0.013492777,-0.034676168,0.047920953,-0.009412042,-0.06386757,-0.046753384,-0.1015228,-0.023294382,-0.033104133,0.065932095,-0.02741891,-0.017446134,-0.07495227,0.028569493,0.10263077,-0.012295145,-0.0059397677,0.03484536,-0.044407967,0.019111037,-0.06929531,0.026144832,0.029874137,-0.09116429,-0.10725283,-0.08720299,-0.04279289,-0.010820184,-0.031431116,-0.005292883,0.021008521,-0.011545139,0.07712757,-0.09115958,-0.012258627,-0.03311954,-0.013639512,0.035925347,0.059422724,-0.001393133,-0.0014603827,0.014668314,0.09881745,0.049696542,0.032272156,0.024336925,0.0036415898,-0.036041934,-0.08299156,0.048258107,0.081771284,-0.051720444,0.011691481,-0.014575896,0.00532802,0.051381584,0.08047803,-0.073607326,-0.100237444,-0.01522158,-0.019024352,0.0803364,0.027742196,-0.029720321,-0.006582235,-0.025168605,0.09760003,0.022307627,0.03992538,0.080426395,0.036992744,-0.07570363,-0.06548258,0.015387849,0.008182491,-0.064216085,-0.010418841,-0.015115742,-0.02553073,0.03464862,-0.075801104,2.7007054e-33,0.04536045,0.07601951,-0.056729738,0.0024338686,0.0016695405,-0.016108593,-0.1130888,0.047675803,-0.045138817,-0.025149923,-0.06811817,-0.087181285,0.058954567,-0.010180797,0.015905807,-0.014889852,-0.031531703,0.042744312,0.03331533,0.06960726,0.03602964,-0.009348175,-0.063227214,-0.05390853,0.012002604,0.027727716,-0.025498457,-0.021811692,-0.018531105,-0.0014953128,0.021437408,-0.11173297,-0.1545131,-0.02650113,0.0018824982,0.028717259,-0.017543845,-0.063553534,0.003401862,0.017664803,0.0013332246,0.009098119,0.03412477,-0.025347993,0.06314967,-0.0045226202,-0.05955895,0.13964991,0.053408913,0.04301865,0.048463736,-0.044841144,0.12254597,0.034047697,-0.03787764,0.062227365,-0.024093432,0.005422405,-0.036786627,0.061028462,0.02143577,0.048530854,-0.03945569,0.081665166,-0.00074032065,-0.0084668035,-0.105388805,0.054559547,0.007829586,0.081194565,-0.03300747,-0.015486319,0.024250224,-0.009410481,0.02928217,-0.07606024,-0.030355157,-0.022552537,0.011548727,0.11809975,-0.023837557,0.002468247,0.021204466,-0.02738041,-0.04943723,0.017704258,0.04435194,0.012236727,0.03810327,0.033460308,0.09051832,-0.0656505,0.02995425,0.0027216978,0.0802332,-2.1179907e-33,0.11583941,-0.11226019,0.075023584,-0.102758996,-0.011542759,0.050650463,0.0032925894,-0.03739919,-0.018452046,-0.053996872,0.0874489,0.04213026,0.017128007,0.010255862,0.053803205,0.0048786416,0.069475606,0.08034696,0.012346076,-0.06612306,-0.007832435,0.003166244,0.012349339,-0.027315974,0.042781144,-0.0027424449,0.010842209,0.0672695,0.03369952,0.02211747,0.029612383,0.0010597146,-0.007530342,0.012617085,0.019716023,0.092094675,-0.06558465,-0.017771052,0.011248673,0.00018158996,-0.033003442,-0.0224903,-0.08430929,0.06471036,0.020810967,0.059767637,-0.0810119,-0.074734345,-0.009253974,-0.028427504,0.09183197,0.0126588335,-0.049865585,0.032850675,0.0056088655,0.051901508,0.008499633,-0.028021017,-0.020522073,-0.05592227,-0.053150464,0.02721745,0.0033116015,0.016276252,0.0051481244,-0.036197897,-0.034735374,0.05432917,0.0066174893,-0.035350326,0.037509482,0.02741727,0.035810962,0.07907706,-0.040000092,0.049831253,0.0156213455,-0.06358209,-0.055972952,-0.029323883,-0.006147642,-0.01765863,0.039114293,-0.068905696,-0.08795546,-0.06921631,-0.045975752,0.08721496,-0.032587744,0.012742274,-0.016718883,-0.022920499,0.039294932,0.045625366,0.12302718,-2.7938155e-08,-0.047972243,-0.020400764,0.03868694,-0.03742592,-0.013267919,0.083400756,0.0030632212,-0.052504383,0.029129213,-0.014380837,0.0005798709,-4.222835e-05,0.051359236,0.094827436,-0.002376232,0.0062614162,0.021572366,0.014216832,0.005611883,0.061342634,-0.09827697,0.011922793,-0.10087563,0.00909379,0.025770659,-0.09573058,0.025329694,0.0722324,0.06629694,-0.05559389,-0.01453571,0.04585476,0.04833362,0.03066521,-0.058815632,0.05279776,0.005447807,-0.0071772933,-0.06604624,0.024474982,0.029914625,-0.05270081,-0.06465358,-0.044462096,0.020177294,-0.034413688,-0.0028185819,0.032260366,0.058912233,0.006669703,0.036661875,-0.018717214,0.07862564,-0.02685367,-0.028646449,-0.00034316373,0.022599457,-0.016683515,0.027014673,0.013726966,0.012247414,0.026687736,0.14728884,-0.09403077 +1.4.3.23,"Contains a noncovalently bound FAD [1,2]. This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. During catalysis, the bound FAD is reoxidized at the expense of molecular oxygen, producing one molecule of hydrogen peroxide. The enzyme shows significant preference for 7-chloro-L-tryptophan over L-tryptophan [1].",384,1.0,-0.05184825,-0.020508807,-0.10689705,-0.035010435,0.047754038,0.036307286,-0.035443712,0.07399156,0.10325364,0.034928117,-0.037077073,-0.037278622,-0.0030518433,0.014933459,-0.09545995,0.09323933,-0.03855312,0.020580694,-0.035990644,0.019419301,0.035702225,0.029858222,0.012416385,-5.182643e-05,0.082077146,0.016607681,0.02711374,0.05421308,-0.040378697,-0.048074525,0.011471832,-0.0031906753,0.033934545,-0.037786804,0.07040089,0.042994633,0.019661684,0.017702395,0.10903545,0.022921497,-0.063462205,-0.02509874,-0.02581859,0.022549842,-0.05859437,-0.002521621,0.03345174,0.03681736,0.029425673,-0.05546992,-0.017919092,-0.04091126,-0.08039073,0.020723293,0.050513305,-0.0026813063,-0.050288405,-0.045557205,0.0027845923,0.005420608,0.039669637,-0.017074807,0.022262523,0.026348053,-0.027224535,-0.115993045,-0.055779815,-0.096138604,0.03199723,-0.02153926,-0.026996657,-0.058752757,0.013737262,0.0065204375,0.03470734,0.010495222,-0.026949935,-0.09351415,-0.034069277,-0.05074778,0.05462545,-0.010952724,0.06783226,0.12742017,0.014039872,-0.007992558,0.07751373,0.018328005,0.054505255,0.02303431,0.0008952017,0.0105170235,-0.014087784,-0.050283734,-0.08956537,0.01796961,0.026182747,0.01986801,-0.01769406,-0.021081353,0.022582049,0.022432879,-0.011949746,-0.077911645,-0.027984524,-0.03751108,0.012952713,0.10325867,0.034688365,-0.07910793,0.0029522644,-0.023592122,-0.014726291,-0.025833813,-0.051865492,0.05647139,0.036746033,-0.1000824,-0.11057438,-0.014840746,-0.040490597,0.013115964,0.01981161,0.049648907,0.0020282357,0.031641982,-0.07979946,4.7706873e-33,0.07864074,0.055887323,-0.08777779,-0.020382347,-0.028657291,-0.017528418,-0.11858627,-0.025882812,0.025837982,-0.015167752,-0.1075449,-0.07220479,-0.024788372,-0.04708398,0.012888259,0.038025927,-0.09531629,-0.04517985,0.012040195,0.01210832,0.014980487,0.018639741,-0.0571526,0.012969327,0.016865883,0.057569638,0.017960284,0.02806905,0.07143267,0.0033157014,-0.0015258569,-0.007619721,-0.09632527,-0.005189357,-0.0086267665,0.022508852,-0.058885247,-0.00050492317,-0.008832528,0.06676509,-0.007887671,0.08459766,0.018707372,0.012878618,0.10033053,-0.048456084,-0.017360484,0.15292722,0.08515029,0.06862681,0.005435366,-0.011799837,0.090358526,0.061043054,-0.09345451,-0.008152856,-0.026355436,-0.0016271339,0.054538075,0.038069956,-0.025560405,0.03150229,-0.0045208777,0.06606499,0.026611686,-0.0025751528,0.008777955,-0.06115052,0.014692672,0.10490831,-0.063070364,-0.03870156,0.0954493,0.008578612,0.025835946,-0.06840671,0.08039811,-0.039430987,0.08315837,0.029490447,0.08640287,-0.040214695,0.0009871974,-0.08130911,-0.027063085,-0.0490229,-0.08887974,-0.09481046,-0.038209442,0.07655563,0.017047709,-0.07954404,-0.04876271,0.012266377,-0.01722262,-5.3153133e-33,0.092773944,-0.12864116,0.08366374,-0.04237016,0.019059032,0.06473744,-0.06263487,-0.0025941646,0.0026933523,-0.027553765,0.06978066,-0.07385461,0.05339163,0.03598493,0.05173944,-0.057075705,-0.03303543,0.10021066,-0.0031576043,0.013411193,-0.04061324,0.043896228,-0.019991638,0.042086232,0.061732087,0.056600075,-0.021400286,0.020242693,0.017201038,0.038509555,0.029698826,-0.01975882,-0.11983362,-0.005262208,-0.024031848,0.05728138,-0.058268826,0.059167817,0.026461555,0.027732512,0.013203875,-0.018061249,-0.0049422667,0.038550187,0.05642748,0.016103575,-0.068889596,0.026908418,0.062386017,-0.12023153,0.012385657,0.004149541,-0.04261727,-0.029975474,0.071229234,0.052567113,0.057281137,0.014507616,0.027159134,-0.037173595,-0.057149176,-0.062225852,0.07072775,-0.004401958,-0.015745036,0.0916066,0.0107100755,0.09144501,0.032241598,0.057840135,0.03971284,-0.0074212,0.007263048,0.04060166,-0.008237657,-0.002347583,-0.01923732,-0.055480868,0.017898941,0.055348184,-0.00027097014,0.05748912,0.024550827,0.0051442324,-0.035162237,-0.043921754,0.031528376,0.057563215,-0.028125482,-0.00979048,0.03750397,0.06359901,0.038236856,0.014089941,0.0747202,-4.27221e-08,0.0661291,-0.051831026,0.07207811,-0.053957272,0.04363562,0.043211423,-0.05248596,-0.02483213,0.03315473,-0.036496583,-0.005470134,0.121478766,-0.016934188,-0.023625739,0.007224985,-0.024266902,-0.041014016,0.011042568,-0.020900875,0.025807597,-0.11105883,-0.0028829803,-0.053898748,-0.009621121,-0.021562207,-0.04604689,0.012188273,-0.0062564104,0.004098127,-0.023591757,0.03122026,0.04258386,-0.05342157,-0.038740747,-0.10331812,-0.009222559,-0.020846527,-0.015888209,-0.08433299,-0.05066038,0.056359917,-0.04486418,-0.07720764,0.02551687,-0.040783223,-0.026331669,0.0028615552,-0.059119776,-0.0755329,-0.036213268,0.058154196,-0.008000632,0.000638921,-0.051369116,-0.118984,0.025140304,-0.05216503,-0.06795069,-0.07149036,-0.08780675,-0.035381082,0.007937272,0.13043825,-0.0140128825 +1.7.5.1,"A membrane-bound enzyme which supports anaerobic respiration on nitrate under anaerobic conditions and in the presence of nitrate. Contains the bicyclic form of the molybdo-bis(molybdopterin guanine dinucleotide) cofactor, iron-sulfur clusters and heme b. Escherichia coli expresses two forms NarA and NarZ, both being comprised of three subunits. ",384,0.99999994,-0.07842306,-0.042084645,-0.10026394,0.014886581,0.0010483599,-0.0059803305,0.0052148295,0.0052652988,0.0028427718,-0.08442982,0.0009606334,-0.06072589,-0.058201034,0.09917394,-0.036742594,-0.00718633,-0.011873537,0.04766563,-0.024726665,-0.028611885,0.020801041,0.04485822,-0.003751301,-0.033174552,0.007224984,-0.017998252,0.0001106174,-0.06557548,-0.009736898,-0.05439303,-0.060334917,0.025253277,0.12558988,-0.05797601,0.11096358,0.096377656,0.015051688,-0.020986367,-0.0052291,0.015663946,-0.025718097,0.08430026,0.027590659,0.015557522,0.044457626,-0.002470658,-0.03516952,0.026403124,-0.007732581,-0.092599206,-0.07125033,-0.07720205,-0.052804448,0.063124985,0.054517042,-0.0185748,-0.044727206,-0.1043725,-0.019804118,-0.012488065,0.107010655,-0.004060926,0.08449702,-0.011750209,0.027607905,-0.040083505,0.08182764,-0.047989577,0.016448848,-0.012127933,-0.09470466,-0.007904485,-0.02530867,-0.025708713,-0.056697324,-0.0046087936,0.061501794,-0.026580328,0.06874814,-0.04127716,0.006412368,0.04707204,-0.018071322,0.030186133,0.031434465,-0.01500355,0.06785604,-0.037776563,0.05024643,0.028725464,-0.024179306,0.007012606,0.043010417,-0.03503301,-0.14612336,-0.056118112,-0.012003833,0.043300245,-0.018370392,0.0055325716,0.053099886,0.08765427,0.062394895,-0.028540894,-0.054153074,-0.025792096,0.041839894,0.044980526,0.0029119374,0.10838521,-0.015246785,0.043290887,0.03517656,-0.045958344,0.033037852,0.021079132,-0.002067136,-0.007690224,0.010202763,0.03169445,-0.00747865,-0.01628339,-0.057133995,-0.022361793,0.01703979,0.0005355355,-0.0744249,3.651174e-33,0.062086906,0.00041140706,-0.0089931125,0.013191194,0.010697979,-0.04601183,-0.09782018,-0.03664719,-0.05074336,0.007971169,-0.030956108,-0.013086554,0.043704126,-0.0029535755,0.008841565,-0.028086167,-0.096667975,-0.006961888,0.061056383,0.030650677,-0.048601855,0.076479144,-0.033441115,-0.0510759,0.07825638,-0.02440573,-0.041757256,-0.067079395,0.019158572,0.0032783449,0.051231477,-0.11103915,-0.129054,0.005584121,0.062785156,-0.061173655,-0.027054302,-0.008159296,-0.04522613,0.01986115,-0.09763966,0.111838244,-0.015504731,-0.019373083,0.08885482,-0.05831651,-0.04448332,0.13025694,0.06737224,0.01112999,-0.00490285,-0.033040397,0.020118076,-0.08701071,-0.018902719,0.016372107,0.00963388,0.030166246,-0.009717431,0.027074996,0.02359953,0.0020494298,-0.06885247,0.015357295,0.049841344,0.008179364,-0.04351243,-0.059262127,0.14705569,0.07292979,-0.11052581,-0.037715383,0.03951146,0.06828125,-0.08631756,-0.11062356,-0.011727604,-0.08344581,-0.010105761,0.021218754,0.016150651,-0.05301827,0.005884916,-0.08706907,-0.036994647,0.010210774,-0.03284985,-0.002308935,0.019323444,-0.018064238,0.01576801,0.0412073,-0.046780195,-0.034628227,0.022905193,-4.269343e-33,0.14045478,-0.10116917,0.0031581705,-0.077940814,-0.05418055,0.035485055,-0.029568302,0.0012155162,-0.025190972,-0.041175794,0.028881092,-0.024791118,0.0816827,-0.0077955187,0.08144992,-0.024653513,-0.013426327,0.049447984,-0.01899851,0.034887463,-0.017424842,0.028031757,-0.04915966,0.030287588,-0.018998265,0.12279656,-0.07612139,0.06813609,0.025218617,0.0071448265,-0.040977176,-0.04282702,-0.07483875,-0.099003606,-0.021598376,0.011811001,0.005562202,0.049865317,-0.06399487,-0.0042201057,0.013890381,0.08758506,0.0366087,0.08785415,-0.017677201,0.059620563,-0.0065736324,0.021090094,-0.017253783,-0.03250137,0.043883257,-0.090831764,-0.06336867,0.05540889,0.020177668,0.04693649,-0.022949494,-0.025785154,-0.022507653,0.04571219,0.01225924,-0.061681375,0.057314266,-0.026700562,0.027273307,0.026867723,-0.01779288,-0.0033591771,0.045250658,-0.014012912,-0.0073937355,0.05313672,0.0016420786,-0.03077874,-0.041711804,0.0232822,-0.056074444,-0.009937026,-0.017430611,0.024851305,-0.0011745999,0.05104902,-0.04634327,0.005654446,0.06082615,-0.02714729,0.0044360664,0.051682223,0.06462527,0.015407105,-0.0077365944,-0.012777134,-0.04601685,0.02645045,-0.017798232,-3.812113e-08,0.08765573,-0.062613785,0.034511037,-0.043626066,-0.004558242,0.05433723,0.014111604,-0.035901334,0.011923445,0.092925765,0.09134553,0.15669315,-0.014068152,0.0037499014,0.053615313,0.094400086,-0.051946834,0.017647859,-0.03608507,-0.012458895,0.011879377,-0.026602184,-0.1191471,0.08273298,0.010385963,-0.024938574,-0.0027008737,0.03711303,-0.019538015,-0.035865657,0.019999674,0.043763194,0.08625175,-0.06055974,-0.048103206,-0.01553392,0.0031374353,-0.04318436,-0.08359953,-0.006255055,0.062518634,0.0064851097,-0.07519615,0.022154663,0.06437594,0.00084423466,-0.00857838,0.028508384,-0.041167963,0.05356291,-0.0103656715,-0.043309443,0.007574391,0.051751684,-0.10358523,0.022607738,0.015554035,-0.050390806,-0.015990378,0.02803355,0.059792414,-0.017154822,0.15449561,-0.037132367 +1.8.1.16,"A dimeric flavoprotein (FAD). The enzyme restores glutathione amide disulfide, which is produced during the reduction of peroxide by EC 1.11.1.17 (glutathione amide-dependent peroxidase), back to glutathione amide (it catalyses the reaction in the opposite direction to that shown). The enzyme belongs to the family of flavoprotein disulfide oxidoreductases, but unlike other members of the family, which are specific for NADPH, it prefers NADH [1].",384,0.99999994,-0.07586544,-0.0048113284,-0.078609295,0.0016700859,0.108334534,0.007635315,-0.062174357,0.09278606,0.063199885,-0.043500192,0.0014209097,0.071983196,-0.074960046,-0.004032067,-0.088683635,0.039445173,-0.01979531,0.013928577,-0.091451116,-0.031092348,-0.010764179,0.00038657247,0.04282873,-0.03477916,0.03675079,0.012049571,0.033064287,-0.014186954,-0.0224941,-0.03804669,0.015311251,0.0018905452,0.045309003,-0.002782498,-0.0316617,0.071107216,0.027641859,-0.0068505853,-0.03850988,-0.002644422,-0.0022535159,-0.0030265064,-0.0132129295,-0.023737717,0.044121586,-0.014787718,-0.026964024,0.07462929,0.02903945,0.044819284,-0.014038521,-0.05244565,-0.0717349,0.043434512,0.04477323,0.03795352,-0.0016062686,-0.028694442,-0.06044432,0.009710631,0.01950642,-0.06780538,0.0030850237,-0.045454916,0.010646811,-0.07131398,0.012174164,-0.069737256,-0.020413112,-0.095103614,-0.037118934,0.007911928,0.009857445,0.012792177,0.0029504735,0.06510442,-0.11752819,-0.032708216,0.058028355,0.017666124,0.095514126,-0.028853454,0.03020015,0.124068655,0.079486966,-0.0013306154,-0.016279617,-0.010865364,0.020043511,0.019396061,-0.07295867,0.028934214,-0.051380374,0.02881952,-0.169081,0.056799848,0.051781207,0.012629407,-0.095248945,-0.0052895523,0.001543442,0.06187968,-0.0062007974,-0.0740979,-0.084383376,-0.039829887,-0.00637594,0.11881228,-0.009074589,-0.05119402,0.005655171,-0.008095481,-0.0027279856,0.00097368844,-0.026092466,0.058832653,0.015463225,-0.03351061,-0.08790143,-0.03226019,-0.022837462,0.1066157,0.06281126,0.07240033,0.027431477,-0.010487657,-0.06557357,4.3789104e-33,0.09633814,0.10415401,-0.03797239,0.012973298,0.006045255,0.009320737,-0.10884069,-0.005409344,0.06405081,-0.03265864,-0.04048173,-0.03488815,-0.0023949633,-0.070373245,0.056739796,-0.01629344,-0.012583714,-0.000873622,0.029493721,-0.08211209,0.07918341,0.08431577,-0.03212407,0.05430983,0.03723795,0.0018283933,-0.047114216,0.0460862,-0.0049186777,0.014157592,-0.0074727433,-0.02844914,-0.057525944,-0.03750949,-0.02208665,0.03696674,-0.10121747,-0.08021643,-0.0591719,0.05123503,-0.055324115,-0.004445344,-0.0011412299,-0.05942197,0.053763106,-0.11588833,-0.034635153,0.11635936,0.032851413,0.07420745,0.019626744,-0.05314593,0.14271988,0.037216138,-0.10555975,0.01286302,-0.040610842,-0.03580157,0.026319109,0.07168487,0.037362933,0.044735942,-0.06127144,0.08421982,-0.09275932,-0.014416066,-0.03349343,-0.043573022,-0.0024551845,0.165958,0.06126171,0.005550429,0.038770117,0.06134225,0.048372503,-0.076392815,0.0014637394,-0.0051119686,0.0315063,-0.019705376,0.0012754508,0.025126519,-0.045091834,-0.046996906,0.0023049677,0.037284736,-0.00515786,-0.03792919,0.026965864,0.01751441,0.04609894,-0.063114606,0.015317881,-0.039332684,0.025894837,-3.616549e-33,0.05339164,-0.07327307,0.0017999012,-0.03795056,0.04420721,0.05714216,0.028324367,-0.006091481,0.044550847,-0.103498034,0.0028727425,-0.047220636,0.0020922867,0.017159041,0.051582117,0.019166874,-0.055255778,0.0013800288,0.025805563,0.011641439,-0.015902108,0.020460013,0.0737128,0.069633745,0.06266007,-0.043802068,0.0119428495,0.018699847,0.05157206,0.06764198,-0.033793837,0.010277805,-0.0688303,-0.004529738,-0.019254481,0.042135715,-0.05884204,-0.01277365,0.008142487,0.04321356,-0.0148501815,-0.011697074,-0.050707784,0.047327798,0.058057345,0.0645897,-0.082298,0.041635245,0.06051938,-0.13495463,0.04525721,0.036454454,0.01953729,0.03819406,0.08473516,0.053380903,0.005221653,0.023985643,-0.0066834628,0.014367777,-0.0010724535,-0.10316481,0.0066726315,0.024778118,0.059359916,0.059952952,0.04397855,0.10647888,-0.030333044,0.035818588,0.0964271,-0.015605746,0.01093708,0.070030026,0.02354841,-0.07062144,-0.04829104,0.07618718,-0.009221116,0.005527616,0.03691179,0.005980786,-0.015359091,-0.042472474,-0.053805802,-0.07179887,0.019946685,0.100641645,-0.021758515,0.028604835,-0.03112924,0.07757557,-0.0129429335,-0.0045986106,0.033371504,-4.253091e-08,0.03249011,-0.04454,0.020857953,-0.0053145657,0.042320453,-0.011755417,0.017071093,0.0012063582,-0.004089828,-0.017159594,-0.030044047,0.15330586,-0.007042438,-0.041178755,0.000818536,-0.016974922,-0.000101205165,0.03527475,-0.011568978,0.005479641,-0.052650522,0.04661788,-0.09639438,-0.0021334637,-0.030961316,-0.012936605,0.008933636,-0.043519247,0.03265921,-0.03185982,0.05973743,-0.0056461333,0.047049843,-0.046820812,-0.12915932,0.039699208,0.017965049,-0.001240588,0.0020342618,-0.00086096727,-0.044432078,-0.019372515,-0.00785162,0.0017079393,-0.005163545,-0.021927444,0.060547434,-0.041641977,-0.056887176,0.00090814894,-0.0006911779,-0.016133374,0.012035166,-0.054385416,-0.10900149,-0.0028236634,-0.028918374,-0.07444872,-0.034885854,-0.11074472,0.00617529,0.030315988,0.13017464,0.034274206 +1.11.1.17,"This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress [1]. The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase).",384,1.0,-0.038574908,-0.039801426,-0.09955758,0.020375505,0.071763225,0.047631778,-0.06020921,0.1260961,-0.014387187,-0.02563414,0.025621764,-0.020887481,-0.03343245,0.00476931,-0.091745764,0.07633971,0.006302744,-0.006968677,-0.0357568,-0.032383222,0.019083846,-0.005772547,-0.041817524,-0.032733645,0.004001205,0.043249447,0.06737026,0.034533374,-0.030162744,-0.066766866,-0.0047033685,-0.0860653,0.052150015,0.010875391,0.0322919,0.11828222,-0.040955678,-0.08353234,0.008144583,-0.028413374,0.0099305995,0.04951474,-0.030003114,-0.030663675,0.038253605,-0.004994893,0.018915761,0.03266322,0.07124322,-0.037192747,0.010687231,-0.09288643,-0.014100484,0.036823392,0.061785523,0.016300421,0.02062982,-0.028539812,-0.056053635,0.067554384,-0.0077411267,-0.016798154,0.018158603,-0.09868998,0.0011166745,-0.038939647,-0.032988943,-0.052047223,-0.055602368,-0.057505786,-0.041544735,-0.025978355,0.071281716,0.013944159,-0.056414947,0.04165694,-0.100984,-0.035768673,0.048432652,-0.018297836,0.065378346,-0.018801266,0.01729581,0.104911886,0.06384393,-0.02018545,0.009147818,-0.033972025,0.06375588,-0.0009063328,-0.02882021,0.029005378,-0.029629622,0.0020736014,-0.10507272,0.046618868,-0.028597144,0.018225368,-0.047608096,-0.012022002,0.019315077,0.06498748,-0.04689459,-0.13358021,-0.092265315,-0.023475619,0.041672837,0.107050195,0.027408434,-0.020108681,-0.0055205044,0.03177613,-0.024368957,-0.0139800515,-0.03135479,0.07906904,0.045909207,-0.043699212,-0.09386108,-0.013385546,0.0037543806,0.041169997,0.044682343,0.012856383,-0.016683174,-0.042779732,-0.038390152,5.745255e-33,0.058909405,0.06760046,0.00761585,0.019487007,-0.011044453,0.013375027,-0.12475985,-0.039585568,0.051606696,-0.081489906,-0.07610121,-0.027615614,-0.05930404,-0.06603433,-0.00728991,0.001848089,-0.03714341,0.021138888,0.024678249,-0.028065084,0.026389277,-0.012859563,-0.057585467,-0.036622077,0.051608562,0.1050684,0.04068052,-0.040550385,0.063618794,-0.011700949,-0.036659762,-0.0020833155,-0.074973375,0.012699808,0.017324915,-0.0034302266,-0.015420622,-0.04748329,-0.021483941,0.02098428,0.00023971667,0.022384338,0.019488003,-0.06747145,0.10574251,-0.11699312,-0.002310693,0.11721745,0.071197025,0.053702276,0.04285486,-0.053790588,0.11103307,0.021170393,-0.11632994,0.004254673,-0.032922164,-0.0383522,0.0640196,0.09200216,0.02774619,0.02628589,-0.04966308,-0.0011051063,0.0146335,0.016909523,-0.09773628,0.00481058,-0.034727797,0.16363026,0.006596399,-0.03838752,0.03277078,0.06769527,-0.0695893,-0.062011074,-0.05228089,0.06576879,0.021064032,-0.010636066,0.0370741,0.052003454,-0.04584226,-0.023397481,-0.004387287,0.05050902,0.02963009,-0.033143934,0.01158233,0.035665955,0.10479058,-0.01842028,-0.041306898,0.0031419313,-0.038960386,-4.5821034e-33,0.08301312,-0.086526655,-0.008341116,-0.051228534,0.07639054,0.013728409,-0.016685875,0.04301527,0.04015378,-0.0061329147,0.05085206,-0.041213043,0.03062537,-0.027394572,0.013711618,0.0026480202,-0.044878054,0.08639914,-0.0338954,-0.052150227,0.013150753,0.0232925,0.0693889,0.01616777,0.04517246,-0.0014494255,0.01385124,0.053841222,0.04979619,0.10876663,-0.0020207297,0.022085505,-0.058475174,-0.014652486,0.012464039,0.047506023,-0.07557465,-0.0058911797,0.029818354,-0.030495116,0.0034346296,0.06610823,0.008143752,0.06915762,0.03664309,0.09092373,-0.08485746,0.014276254,-0.03774595,-0.09470092,0.053159542,-0.06411043,-0.00048298202,-0.03530143,0.040810157,0.012506099,-0.0642487,-0.023541376,-0.062016103,0.033018768,-0.030384738,-0.047499962,-0.0051085325,0.021086259,0.007114645,0.035852097,0.0030421698,0.043870397,-0.018167788,0.09173578,0.078963704,-0.006489026,0.0060707326,0.06101082,0.009685835,-0.0035645256,-0.037379343,0.052763328,0.0149319805,-0.016850816,0.06784941,0.004862585,-0.013128496,-0.065282755,0.0038429056,-0.005748404,-0.024342785,0.18234485,-0.034685347,0.027591474,-0.05228708,0.043790072,-0.033589505,0.02775237,0.017108487,-4.3546397e-08,-0.03932339,-0.043234468,0.053556573,-0.040345367,0.025234593,-0.015217614,0.014946249,-0.006559135,0.031605877,-0.038787887,0.022446152,0.08456574,-0.03202849,-0.045662522,-0.068264365,0.055101942,0.066426285,0.055464145,0.025649998,0.0715603,-0.042263795,0.012466955,-0.10018968,-0.007631345,-0.0025351115,0.0005323594,0.019233616,0.046393447,-0.03388377,0.016316023,0.07147987,-0.00029603497,-0.0035956663,-0.043661498,-0.10968269,0.05885835,-0.002276292,0.03466044,-0.027524438,-0.068224676,0.027514312,0.036562588,-0.02918525,-0.00041101547,-0.03346038,0.011113695,-0.016776485,-0.025501093,-0.023810284,0.024951067,0.02981265,-0.042430937,0.019963872,-0.06652384,-0.15951936,0.00452518,0.01277957,-0.03795593,-0.038099967,-0.08441955,0.0058633685,-0.017110644,0.15851395,0.10657428 +1.13.12.17,"The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P-450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold [1]. Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A [2]. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine [3].",384,0.99999994,-0.073749185,-0.033479996,-0.13063523,-0.027466435,-0.014347377,0.06737932,-0.048164535,0.056904066,0.066083044,-0.019069614,-0.065353796,-0.072545424,-0.036246262,0.019138489,-0.107761145,0.037005097,-0.051124632,0.031567946,0.0013990034,0.0076114754,0.0095226355,-0.0037377973,0.005055688,-0.0027677277,0.0136004295,0.016961833,0.012562594,0.04657615,-0.08942692,-0.08844095,0.10863022,0.025437962,0.014951481,-0.069157206,0.03282003,0.13893035,-0.028800994,-0.05202461,0.033422675,0.0012059563,-0.08740195,0.050588075,-0.008018392,0.078140646,0.03720423,0.0038189306,0.011154505,0.10042376,-0.0011034275,-0.0013230656,0.021004913,-0.026090708,-0.13062598,0.057923295,0.04779567,0.051808614,-0.053075995,0.02369381,0.005550508,-0.045593422,0.013499131,0.013448708,0.019119846,-0.0001271719,-0.046630498,0.010042975,-0.0065259193,-0.056559376,0.06449035,-0.03137423,-0.069399565,-0.017070865,-0.023963017,-0.0010096988,-0.0156753,0.029864825,0.012360524,0.0018361334,0.020986825,-0.030577065,0.07211928,0.053576116,0.023487438,0.08880154,0.05458189,-0.024896374,-0.014632422,-0.0609382,0.08588559,0.0032470473,0.06267473,0.020520983,0.008312983,-0.060740896,-0.07690212,0.038220547,-0.04660686,0.050333798,-0.01659394,0.008948257,-0.011257126,-0.017699173,0.0040883347,-0.09879923,-0.08435454,-0.01796256,-0.00032498103,0.095257185,0.0013785127,-0.06261815,-0.044307746,0.019911937,0.07617351,-0.07702638,0.0034305153,0.1010307,-0.013164086,-0.05953535,-0.03319511,0.03086295,-0.022668922,0.024226371,0.05604419,0.006344617,-0.024657683,0.024043385,-0.09973385,6.042284e-33,0.023503054,0.033297244,-0.010933593,0.03871367,0.023015482,-0.03879261,-0.044361267,0.02438945,-0.074222095,-0.078091756,-0.011291556,-0.050225362,0.034535654,-0.028618068,-0.02358695,0.006905594,-0.05483003,0.040947054,-0.027235951,-0.006118307,-0.025202256,0.13284259,-0.003244438,-0.03705895,-0.009549576,0.015379683,-0.02245377,0.009447465,0.08688112,0.01822847,0.020688735,-0.034909125,-0.12588578,0.022980709,-0.015005116,0.056255713,-0.06563751,-0.06921848,0.014759838,0.067189105,-0.022834308,0.017741447,-0.08220839,-0.00068307156,0.12402269,-0.07908647,-0.060252864,0.13799386,0.034978766,0.010805646,0.06497967,0.014003129,0.10231909,0.027577674,-0.07595643,0.048956487,-0.010333844,0.042488772,0.05431808,0.07732521,0.028511677,0.09324437,-0.043285724,0.0020542145,0.04963917,-0.011325409,-0.03312169,-0.07305277,-0.003982185,0.024393579,0.021781461,-0.01095884,0.053164124,0.023831572,0.050968062,0.00493138,0.030383848,0.03682537,0.025210416,0.002697643,0.0036284027,-0.0055765044,-0.013162227,-0.085042626,-0.013366039,-0.03233562,-0.016972668,-0.09892615,-0.03173689,0.0758401,0.08314917,-0.06714042,-0.07262283,-0.0596229,0.062443506,-4.464224e-33,0.058858085,-0.09415949,0.0033679425,-0.063808024,-0.020573713,0.06822044,-0.005651801,-0.08059743,-0.015805975,-0.0414006,0.038060147,-0.07714249,-0.028775457,-0.0054578763,0.013385819,-0.06312845,0.040286683,0.09877256,-0.016087804,-0.01722738,0.033123367,0.09587276,0.023348767,0.04444847,-0.04542104,0.034986038,0.0111706555,0.09166932,0.0983778,0.042893376,-0.0045048413,-0.037246015,-0.09396814,0.0050929156,-0.028272351,0.048184033,-0.09119284,-0.01693929,-0.006995613,-0.015898142,0.0019531366,0.039293885,-0.056182772,-0.03912993,0.04160176,0.079885155,-0.11523354,0.027963873,0.091956526,-0.08428151,0.03126649,-0.006566614,-0.06731853,-0.0188926,0.0180936,0.036042087,0.04091748,-0.039091177,0.06543499,-0.0073357373,-0.031998433,-0.055978954,0.05624096,-0.025606798,0.09669023,0.08843557,0.075662985,0.043536525,0.05323805,-0.075580254,0.052894082,-0.009482302,0.043388925,0.02516443,-0.036451228,0.04979889,0.020267993,-0.031227637,-0.006613111,-0.056682874,-0.023200696,-0.044557966,0.069810234,-0.010094814,0.020804295,-0.04472871,-0.014180699,0.023199083,0.023792656,0.03353904,0.036750726,0.015162404,0.027392762,0.08612633,0.15482728,-4.676396e-08,0.070950605,-0.049747713,0.06183795,-0.03788548,-0.0014719614,0.03650521,0.014308133,-0.03404067,-0.031875707,-0.054138683,-0.0036494269,0.05766328,0.02043085,-0.005883439,0.020785948,0.03104452,-0.04009906,-0.023204124,-0.017188646,-0.061195347,-0.052588057,0.02998776,-0.014489006,0.05013057,-0.023436962,-0.06127612,0.047631282,0.020465633,0.051454652,-0.03451159,0.028003152,0.007496803,0.008907055,0.0017667592,-0.06146146,-0.061938252,-0.067864396,0.010728559,-0.062221758,0.052875247,-0.014612858,-0.020237856,-0.015827442,0.049347643,0.0059278468,-0.060202982,0.00867365,0.016132457,-0.04830981,-0.015197548,0.032997843,0.029890947,-0.008735616,-0.07121072,-0.12767044,0.03890031,-0.024396783,-0.034542844,-0.040080205,-0.047127973,-0.0317566,0.007069516,0.13815124,-0.00617689 +1.14.12.21,"The enzyme is involved in aerobic benzoate metabolism in Azoarcus evansii. BoxB functions as the oxygenase part of benzoyl-CoA oxygenase in conjunction with BoxA, the reductase component, which upon binding of benzoyl-CoA, transfers two electrons to the ring in the course of dioxygenation. BoxA is a homodimeric 46 kDa iron-sulfur-flavoprotein (FAD), BoxB is a monomeric iron-protein [1].",384,1.0,-0.05367171,0.013934587,-0.09596713,0.040423367,0.07753839,0.028823333,-0.04528765,-0.017909778,0.030099912,-0.051626425,-0.057378132,-0.019334184,-0.0857297,-0.02510409,-0.11771602,-0.0077888663,-0.08572999,0.025623497,-0.095615834,-0.030900098,-0.027720034,0.086432144,0.0140040275,-0.0021771833,-0.04541268,-0.0850717,-0.0011708677,-0.009797945,-0.05939688,-0.07600884,0.10136298,0.014948762,0.07023859,-0.011742942,-0.018943422,0.08492853,0.019597547,-0.12017667,0.014776906,0.0037758446,-0.020351598,0.041948583,-0.006042773,0.03707841,-0.015330664,0.018468238,0.039724104,-0.035452157,0.0080141,0.012482257,-0.010009413,0.013052271,-0.100856625,0.08560855,-0.05288197,0.017715951,0.02594844,-0.03326511,-0.029114597,0.022933535,-0.0089711845,0.05337269,0.025029048,0.016567875,0.029870924,0.011064148,-0.0664845,-0.026600381,-0.06783277,-0.118395396,-0.050261386,-0.05465033,-0.08501169,-0.018955318,-0.024818221,0.0074982163,-0.04460754,-0.027085606,0.09689447,0.018636514,-0.01802745,-0.0333315,0.017901646,0.07123485,0.0012471875,0.008910784,-0.07870741,0.008455631,-0.007894476,0.055297013,0.047277708,0.031280134,0.0032072226,0.017608598,-0.060428012,-0.012522944,0.030532328,0.026973639,-0.05272915,-0.0007484791,-0.015407124,0.005273623,0.022670567,-0.09586857,-0.08551764,-0.066668585,0.012515179,0.1007952,0.018546041,0.023885407,-0.017156567,-0.008204009,0.05475827,-0.003271964,0.055806704,0.081889175,0.022951534,-0.061961524,-0.07601517,-0.036678515,0.028884755,-0.02524636,0.041355018,-0.004220688,-0.036096327,-0.009559863,-0.105453506,3.4380462e-33,0.07921571,-0.033743516,-0.022609599,0.034916937,0.016684433,-0.01009054,-0.09319422,-0.024226865,-0.021316871,0.029933596,-0.12181837,-0.001851616,0.054686263,-0.08013722,-0.014370697,-0.024336124,-0.09173446,-0.0051466003,0.05329494,0.021061081,0.043113768,0.035414267,-0.02972037,0.048612483,0.06372683,0.067624465,-0.019093322,-0.00870463,-0.0314235,0.025836704,0.02077363,-0.0956948,-0.15197814,-0.047796965,0.010732935,-0.009612524,-0.04417601,-0.022647796,-0.096168995,0.07904074,0.07713483,-0.0161894,0.01818645,0.013272178,0.07494081,-0.044685174,-0.06474686,0.1666075,0.024477009,0.037206773,0.01354523,-0.04164852,0.08199448,0.061550926,-0.0032452573,0.056540556,-0.064479195,0.072415434,0.07106627,0.06780015,0.09579972,0.045090985,-0.034212783,0.04916916,-0.016190045,0.02483398,-0.11954446,0.006800624,-0.073377185,0.086956665,0.048896212,-0.033843588,0.039633308,0.025026532,0.025250915,-0.06012525,-0.030626245,-0.016498422,0.00900278,0.009224913,0.00460837,0.007411805,0.0013166214,-0.05224491,-0.07026344,-0.047184598,0.016548174,0.01779806,-0.03831318,-0.024202477,0.11911646,-0.04770314,-0.0052715554,-0.02788929,0.05125586,-3.5192732e-33,0.053800132,-0.07694802,0.0678665,-0.08171413,0.06121295,0.0034687067,0.07625832,-0.049396932,0.05491394,-0.007866318,0.0066226786,-0.0056506703,-0.033965122,-9.7824755e-05,0.057352312,0.020655984,0.0032492578,0.024873417,0.037545364,0.021915298,-0.06685922,0.012933532,0.013177387,0.0013999377,-0.046247907,-0.020758124,-0.022582963,0.07549718,0.016352203,0.020738576,0.050037805,0.059161544,-0.06924241,0.0022593269,-0.10706014,0.082667455,0.010944904,-0.023708213,-0.0055460962,-0.006030156,-0.032261897,-0.029564843,-0.050089113,0.11112217,0.05977429,0.035333645,-0.15284275,-0.010696096,0.018004663,-0.021285405,0.013500219,0.02784156,-0.0127623435,0.032003067,0.026508553,0.098015115,0.030732144,0.03487614,0.018875979,-0.0046463055,0.020358624,-0.042820018,0.07519115,0.038509473,0.027971368,-0.0014498876,0.03760151,0.06277619,0.010322964,0.006170863,0.095646106,0.026775092,0.009630068,0.07532288,-0.050967168,0.020718724,-0.004871309,0.021564689,-0.014369638,0.03552348,-0.049858086,0.0050502755,0.03548184,-0.033337533,-0.0028562672,-0.10905236,0.001131468,0.055837844,-0.011021731,-0.03118122,-0.05459687,-0.047180295,-0.031012783,0.04487661,0.0600165,-3.526064e-08,-0.06764358,-0.08135761,0.011804833,-0.01883527,-0.029445065,0.07809485,0.023243194,0.041349746,-0.006564185,-0.0731291,0.017088197,0.07796073,-0.011662839,0.01437322,0.07812697,0.040164553,-0.0404732,0.0523435,-0.0025834558,0.062799886,0.05886221,0.024044078,0.003520986,0.034252968,-0.05561826,-0.08038688,0.010660567,0.038383953,0.034495447,-0.023972936,0.0021056905,0.08000688,0.08343821,-0.014866565,-0.100194044,-0.0087610325,-0.012633891,0.009041501,-0.101293676,0.040647354,-0.020165402,-0.076158635,-0.06861975,-0.06774756,0.061443783,-0.026608132,-0.009687414,0.04129741,0.019762766,0.012556496,0.07600565,0.03109749,0.02078002,0.041110497,-0.016549053,0.021678515,-0.03060237,-0.0326099,0.08339913,0.015614677,-0.045127906,0.037900165,0.09940075,-0.07480241 +1.14.13.111,"A flavoprotein. Methanesulfonate is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Compared with EC 1.14.14.5, alkanesulfonate monooxygenase, this enzyme has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methanesulfonate to butanesulfonate) and excludes all larger molecules, such as arylsulfonates [1]. The enzyme from the bacterium Methylosulfonomonas methylovora is a multicomponent system comprising a hydroxylase, a reductase (MsmD) and a ferredoxin (MsmC). The hydroxylase has both large (MsmA) and small (MsmB) subunits, with each large subunit containing a Rieske-type [2Fe-2S] cluster. cf. EC 1.14.14.34, methanesulfonate monooxygenase (FMNH2).",384,0.99999994,0.015570667,-0.05350774,-0.14109461,-0.039838605,0.064484216,0.05122412,-0.099369094,0.06388927,0.030204765,-0.09834696,-0.003459216,-0.04326598,-0.033254184,-0.00017304451,-0.09948495,0.06681184,-0.03143507,-0.036408328,0.026325367,0.011942289,0.07920482,-0.0037945088,-0.046996098,-0.018396275,-0.018815886,0.06252057,-0.0010171814,0.00048255443,-0.09982861,-0.03904873,0.06417467,0.01926848,0.078754455,0.00615944,-0.013724408,0.13129255,0.04757978,-0.020235414,0.026617289,-0.013341279,-0.02735101,0.018724207,0.02003362,-0.011369961,-0.0081505105,-0.0429678,-0.0020100211,0.012339423,-0.03174877,-0.06624004,-0.07837268,-0.041526526,-0.07664744,0.117051266,0.059577215,-0.0014584825,-0.0010693534,-0.013961335,-0.043846346,-0.037698228,-0.04169137,-0.05757111,0.07185602,-0.024378011,0.019978436,-0.045663524,0.023831759,-0.06310893,0.06969024,-0.045998003,-0.12265503,0.014308658,0.006971303,0.08621902,-0.031032795,0.13612726,0.03500008,0.028311236,0.08430474,-0.029323418,0.022000302,0.04851581,0.06577933,0.045271177,0.052611608,-0.07045227,-0.031323537,-0.011386907,0.06585644,0.08525971,0.054709475,0.020683154,0.018285394,-0.02776628,-0.04201766,-0.03839836,0.03865635,0.0029434748,0.011796163,-0.05862759,0.009936283,0.032806773,-0.016179217,-0.06024167,-0.05809051,-0.00027044505,-0.0016223524,0.07812463,0.03529128,-0.06724361,-0.019388234,0.034348052,0.024497168,-0.018291278,-0.0130164195,0.005530537,0.05531326,-0.08209072,-0.09391118,0.04302022,-0.051703658,0.03176338,0.055563044,0.010930284,0.011482806,0.028661847,-0.16297132,3.92023e-33,0.079398215,0.04990966,0.0026847976,-0.018220255,-0.0018404276,-0.0081663625,-0.02625957,0.04070693,-0.004524112,-0.019237673,-0.064739496,-0.024582187,0.024874555,-0.011839898,0.028224053,-0.022440663,-0.035951883,0.00018165118,0.036587246,-0.06534434,-0.02336986,0.048217393,-0.015765883,-0.087176286,0.04197442,0.03719789,0.040921442,-0.021966122,-0.02910368,0.013747496,-0.0031765879,-0.11169743,-0.14370632,0.02622491,0.078822784,-0.0084919175,-0.062505335,-0.04155071,-0.025520572,0.007411266,-0.06905783,0.03270445,0.016823696,-0.05604369,0.053789295,-0.051778216,-0.1039008,0.10397068,0.04898456,0.08855475,-0.011264105,-0.027852058,0.12510894,0.009286618,-0.032569524,0.037059996,-0.024393518,-0.0075600957,0.03872864,0.033309396,-0.036606327,0.049497765,-0.053761326,0.014076147,0.0004425349,0.021773435,-0.037747957,-0.019848775,0.011233075,0.119104624,0.057560485,-0.028729368,0.08377896,0.04243735,-0.022597214,-0.046498735,-0.018388208,-0.047354322,0.0126414895,0.06769444,0.01808793,-0.046039455,-0.011154643,-0.06472156,-0.123462625,0.026999246,-0.008841455,-0.04542996,-0.06667212,0.07264342,-0.0114585655,-0.08511594,-0.02227941,0.022525163,0.0009058361,-3.8882664e-33,0.08398346,-0.05734807,0.023755385,-0.118465275,-0.03181574,0.094448954,0.05380186,0.009165067,-0.07715746,-0.059800614,0.038050327,0.031134404,0.023694966,-0.018398702,-0.026550189,0.038343683,0.014971021,0.007761928,0.06764014,0.0071312827,-0.00065460574,0.08606125,-0.032229993,0.097650565,0.026920099,0.013911418,0.018600235,0.04688044,0.04280402,0.022535948,0.009758757,0.016466893,-0.010935896,-0.058321793,0.021730352,0.02442309,-0.07268857,-0.032593437,0.022317214,0.047451705,0.0033148169,0.013123853,-0.030538091,0.036707517,0.024300627,0.08418615,-0.10051537,0.0138627235,0.11852936,-0.012814408,-0.044822082,-0.016554313,-0.04916867,0.076501586,0.033754576,-0.020307858,-0.000777779,0.016787013,-0.024226183,-0.05686467,-0.02755706,-0.089589044,-0.021587782,-0.056205858,0.034663353,0.1185966,0.034193728,-0.0014079243,0.0014759167,0.012433751,0.09389239,-0.039364137,0.07962361,0.010076827,-0.03318629,-0.05664463,-0.022773195,0.011259997,-0.04381073,0.0055872467,0.108467065,-0.0018256252,0.061583124,-0.04808406,-0.011590305,-0.0968125,0.044011485,0.03274666,-0.046179395,0.04026677,0.023849813,0.024963077,-0.061329093,0.011441784,0.040337786,-4.712206e-08,0.035947878,-0.089720845,0.04845586,-0.0045323325,-0.027154978,0.06281814,-0.032889195,-0.008348248,-0.00983351,-0.0015093527,0.027936123,0.06970764,0.00052956026,0.01467145,0.04829815,-0.056925584,-0.06774274,-0.018901551,-0.0071267583,-0.011177511,-0.07414492,-0.012611173,-0.10710989,0.026573522,0.056638803,-0.03609533,-0.02087709,-0.027647357,0.060158003,0.009194963,0.001930157,0.0674788,0.016484788,0.018716631,-0.13153806,0.04020865,-0.048224166,-0.026593713,0.0035046618,0.010646839,0.005574289,0.018621575,-0.03074627,0.034119587,0.04290221,0.006886328,-0.0036128878,0.0634102,-0.01574954,-0.0009745888,0.05976939,-0.026357917,0.023100274,0.0033102864,-0.08240167,0.02547881,0.001600024,-0.04629533,0.012876408,-0.020130336,0.044480458,-0.01663709,0.15292278,-0.023794407 +1.14.13.112,"This enzyme is involved in brassinosteroid biosynthesis. C-23 hydroxylation shortcuts bypass campestanol, 6-deoxocathasterone, and 6-deoxoteasterone and lead directly from (22S,24R)-22-hydroxy-5alpha-ergostan-3-one and 3-epi-6-deoxocathasterone to 3-dehydro-6-deoxoteasterone and 6-deoxotyphasterol [1]. ",384,1.0,-0.13816077,0.033652656,-0.052475814,-0.028134761,0.021143861,0.10330986,-0.10566755,0.08805781,-0.04022236,-0.0028829013,0.039425828,-0.061629847,-0.05536409,-0.12876737,-0.050633285,0.0066832276,-0.08181158,0.046205807,0.013815186,-0.083935775,-0.043634914,-0.0077057006,-0.006667176,0.00399309,0.06888599,0.0758997,-0.0013049212,0.01159623,-0.015010021,-0.04883756,-0.029156646,-0.004471398,0.031758726,0.004708673,-0.049967352,0.05826228,-0.09411301,-0.025326591,0.055656433,0.031456914,0.057406247,-0.0036282663,0.013852579,0.061126,-0.023950376,-0.056818616,-0.11857747,0.06278291,0.034724753,0.0102333175,0.02357571,0.010312425,-0.030599754,0.06880929,0.017678002,-0.03604554,0.01706627,0.029638924,0.0071871076,0.024710778,0.03490333,-0.03721089,-0.031547334,-0.031015467,-0.021021524,-0.018647373,-0.010557345,-0.06791366,0.0050082747,-0.045578245,0.02474798,-0.08353727,-0.101934426,-0.008805601,-0.0722206,0.11361295,-0.0022894004,-0.022573158,-0.017753625,-0.00082320964,0.02629627,0.038428377,0.048160005,0.06066121,0.04394885,0.024013165,-0.027172627,0.03115274,0.0034296971,0.09879935,-0.0020105648,-0.051064402,-0.0886485,-0.037448134,-0.028140798,0.095361106,0.04908393,-0.0004437465,-0.020077145,-0.006026474,0.046540737,0.09145165,-0.03989838,-0.1090087,-0.018387794,0.040473208,0.04940709,-0.021490276,-0.024703728,-0.054661117,0.018849531,0.0077702245,-0.0037553261,0.0026601749,-0.03714402,0.07907651,-0.015733937,-0.05358102,0.0059098112,-0.016819762,0.01606598,-0.02438551,-0.062365957,-0.021743396,-0.04406295,-0.051503193,-0.061068118,4.1122245e-33,0.040479384,-0.0007514644,-0.005261608,-0.00092383235,0.011020053,0.06447036,-0.063586734,-0.02883729,-0.08395043,-0.005723645,-0.06626152,-0.09032697,0.039858874,-0.026771497,-0.031458557,-0.014689732,0.017378831,0.02231264,0.06922707,-0.07087726,-0.0012842346,0.0005306161,-0.14143924,-0.09167943,-0.0052467845,0.07113162,9.0399706e-05,0.01594115,0.040893845,-0.01970416,-0.05202652,-0.021888878,-0.03058005,0.015697002,0.07448982,-0.052659675,-0.051197566,-0.0607246,-0.011649,0.046089742,0.023889828,0.077632725,-0.074875124,0.06318451,0.03444265,-0.020907663,-0.02063179,-0.0054479428,0.1297553,0.06910514,0.051860627,0.016962772,0.08823386,0.028923841,0.04025148,0.07071179,-0.009767433,0.02081682,0.0043619103,0.016303306,0.025397724,0.06534594,-0.0018095906,0.00407419,0.09093307,-0.019423852,-0.09014987,-0.012580608,-0.040655874,0.054488134,-0.051583663,-0.084889285,0.050784692,0.026930466,0.023928506,0.07952396,-8.324676e-05,0.06413074,0.04493315,-0.084277034,0.012962954,-0.016054284,0.026513431,-0.02879343,-0.051745333,0.076182865,-0.1052678,-0.089671984,0.009102617,0.031291567,0.12898532,-0.06842845,-0.14918783,0.035324063,-0.043084204,-4.633303e-33,0.05695528,-0.045407686,0.04782511,-0.12566827,0.013068971,0.023350338,-0.02560414,-0.043683883,0.07636984,0.057925012,0.06631952,0.028801298,0.024561418,-0.043650426,0.050848976,0.013265209,0.039948933,0.08407417,-0.10537519,0.001961457,-0.0031176049,0.07243515,-0.058646202,0.09411439,-0.076137975,0.019617708,-0.012836837,0.047789406,0.071223766,0.026861208,0.016499031,-0.008475294,0.000680167,-0.019480612,0.021953164,0.0731932,0.012108836,0.07613252,0.004133522,0.0038420742,-0.021664627,-0.005228287,0.019657394,0.07517964,0.07385061,0.047966126,-0.058755066,-0.007655887,-0.07763412,0.03237583,0.002791931,0.03824519,-0.014396926,0.048308324,0.013773091,-0.027241642,0.05364273,-0.08138816,0.023013605,-0.022288395,0.057955876,-0.04241286,0.024723334,0.00937186,-0.0032631801,0.07592815,-0.020761948,0.033088468,0.01715265,0.050273582,0.042505298,-0.005889671,-0.003019131,0.015571443,-0.012045608,-0.046157323,0.0006175096,-0.0083154505,-0.0065897545,-0.013712893,0.03696331,-0.0014440175,-0.010785552,-0.06489535,-0.0114759,-0.06967329,-0.006037825,0.09773283,-0.030201089,0.051030774,-0.024659714,0.009338876,-0.09940009,0.07324732,0.06888427,-4.3791637e-08,0.021239048,-0.041771773,0.02972343,-0.012650499,-0.06410554,-0.002837373,0.029690964,0.03525902,0.03407621,-0.044274725,-0.0047707916,0.05461092,0.03456502,-0.033174332,0.08299196,0.00081488397,0.02270936,0.0032463165,-0.008000112,0.002823525,-0.024595749,-0.0028082938,0.007867233,-0.055430453,-0.04525815,-0.029881286,0.10433095,0.11636938,0.01862842,0.018466739,0.042952143,0.033426523,-0.05245217,-0.00067366165,-0.04499831,0.038968865,-0.0073337737,-0.04670741,0.019664615,-0.00989884,-0.058817152,-0.015300112,-0.06499326,0.052619528,-0.03969799,-0.01121505,0.034383766,0.089631625,0.027733875,-0.06675883,-0.024667365,-0.033604242,-0.030871576,-0.06574301,-0.057026412,0.06911215,-0.0012423594,0.018668,-0.027066922,-0.07134241,-0.061256252,-0.019418838,0.18746573,0.019331982 +1.14.15.8,"The enzyme from the bacterium Bacillus megaterium hydroxylates a variety of 3-oxo-Delta4-steroids in position 15beta. Ring A-reduced, aromatic, and 3beta-hydroxy-Delta4-steroids do not serve as substrates [2].",384,1.0000001,0.0028433183,-0.008554547,-0.056674648,-0.09299562,-0.05496891,-0.0039045021,-0.06121788,0.014261655,0.007559035,-0.036692206,0.0018585941,-0.017113352,-0.01119113,0.013457175,0.013087586,0.03630552,-0.010856751,0.046161093,0.031442497,-0.004373658,0.096722744,-0.0027881586,-0.03400625,0.0012925451,-0.0062230458,0.017243521,0.07169576,-0.0023548333,-0.05305234,-0.09263673,0.014222873,0.06661238,0.02454037,-0.09304947,0.0110033555,0.041264374,-0.08012921,-0.039738722,0.077098124,0.07408458,0.108871646,0.046067186,0.059183367,-0.034151405,-0.0535947,-0.020841867,-0.0077098086,0.019815534,0.055194497,-0.075215176,-0.035266396,-0.07424223,-0.0026519927,0.08457262,-0.029969862,-0.060569424,-0.07125363,-0.007441273,-0.036833566,0.06259737,0.032980174,0.04327894,0.020183673,0.0136789605,0.0016495785,-0.019327868,-0.026116941,-0.05332723,-0.07233817,-0.023572654,-0.031865194,-0.020132396,0.014547061,0.060807366,-0.022360153,0.040088747,-0.027471198,-0.02737888,0.07728115,-0.029649539,-0.016173057,-0.048488583,-0.0068550324,0.1432899,0.04478198,0.0025085742,0.027403494,-0.01441982,-0.0084075425,0.059959024,0.030013174,0.032249603,-0.033392895,-0.016960002,-0.104811914,0.034531362,-0.026719414,-0.0061927387,-0.0083388,0.00078893575,0.021012593,0.014413177,-0.048442986,-0.024617447,-0.038535163,-0.008608591,0.050979454,0.10951085,0.049999293,0.017163893,0.029386729,0.03361953,0.008918722,-0.043375522,-0.08767657,0.038716268,0.011706696,-0.04938701,-0.11994652,-0.13280134,-0.0075816205,-0.0144458115,0.013675461,-0.06475178,-0.044897646,0.07182354,-0.055125725,9.396572e-34,0.10837978,-0.04484367,0.040872555,0.005228755,0.0047652866,-0.027662238,-0.039182268,-0.00866781,-0.0021254248,-0.081958994,-0.0868187,-0.014841544,0.039308574,0.06688861,0.043755103,-0.016962007,0.06214128,0.02401411,0.12959468,0.009733045,0.034109794,0.06731348,-0.013857596,0.025154473,-0.0044773114,0.057219923,0.03883596,-0.036814585,-0.024857264,0.023036944,-0.034240115,-0.04332498,-0.04148168,-0.05169208,0.04948633,-0.032056354,-0.023400383,-0.022923682,-0.05311281,0.019772524,0.024614342,0.011699713,-0.029508999,-0.047094256,0.029545253,0.054289103,-0.055120017,0.06602244,0.097410895,0.057589687,0.031174764,0.025709268,0.11305289,0.010775111,-0.016492177,0.07225818,-0.031979438,0.046072014,-0.0039954092,0.0021567843,-0.0067179007,0.10413124,-0.057041626,0.10625671,-0.05003204,0.046971645,-0.010155142,-0.051744606,-0.06414283,0.034728546,-0.030349728,0.045925815,0.07904849,0.0031577053,0.036684755,0.028922355,-0.028559936,-0.014395537,0.005974807,-0.038242735,0.024445599,-0.03946731,0.057603475,-0.030469181,-0.01846529,0.017313628,0.021875069,0.0017537402,0.041316826,0.019275488,0.035962664,-0.090448506,-0.030978987,0.018161263,-0.07591624,-1.5740576e-33,0.06424299,-0.08186683,0.1301093,-0.12158244,-0.038315028,0.025901977,0.067279376,0.014789894,0.0028566236,-0.017332029,0.025329469,0.02579101,-0.018102417,-0.09795292,0.058151443,-0.015224978,-0.02689212,0.06210997,-0.05730427,-0.04881174,0.046883598,0.10998387,0.017677676,0.025862949,-0.0030749594,0.020485813,0.059973378,0.09968563,0.03837059,-0.011390765,0.022907618,0.027001593,0.055871606,-0.018558027,-0.07638143,0.057468098,-0.0046854666,0.0030757275,0.014234852,-0.00329434,-0.050898828,-0.017890185,-0.03241598,0.05945723,0.07904427,0.024677629,-0.09318477,0.025704527,0.03421416,-0.018392805,-0.025570838,-0.04919735,-0.016590683,-0.05757864,0.020147795,-0.024203174,-0.05132588,-0.0058405064,0.0070502427,-0.08702291,-0.028582357,-0.08541593,0.07846479,0.003564889,-0.021133402,0.12887026,0.06230537,-0.054536007,-0.02203988,0.030377002,0.0047087544,0.014216844,-0.03699918,0.08277905,0.0013297118,0.0207192,-0.10578891,-0.027726235,-0.03818361,0.07043861,-0.030979969,0.01803743,-0.0065137157,-0.0966642,0.04392446,-0.03447828,-0.0020543993,0.04060544,0.039734907,0.023174448,-0.02088882,0.018401252,-0.0068971817,0.015919097,0.06560049,-3.543633e-08,0.09512171,-0.0373583,0.038850825,0.031405408,-0.10083482,-0.008594553,-0.013179272,0.037833918,0.1500655,-0.069702104,0.020104673,0.08376128,-0.022105219,-0.021758007,0.06743191,-0.04879481,-0.057953812,-0.07551192,-0.05781452,-0.042420026,-0.090747885,-0.014029263,-0.018419286,0.025692165,0.039730247,-0.08098346,-0.026725104,0.0010318726,-0.023312373,-0.02872887,0.05744831,0.034135286,0.012856162,-0.017297082,-0.056155317,-0.010623652,-0.02489155,0.020580627,0.058625393,0.080254085,-0.008874598,-0.12206332,-0.06789691,0.06306464,0.049198456,-0.008793112,-0.10658908,0.07038707,0.0065522105,-0.040489465,-0.024311801,0.017417695,-0.048507206,-0.04699816,-0.08611332,0.014530448,-0.047736533,-0.025554253,-0.07649715,-0.041759983,0.035276864,-0.018748865,0.16925703,0.0035785437 +1.14.99.39,"The enzyme catalyses the first reaction in the pathway of ammonia oxidation to nitrite. It contains copper [1], iron [5] and possibly zinc [9]. The enzyme requires two electrons, which are derived indirectly from the quinone pool via a membrane-bound donor.",384,1.0,-0.083941855,0.018733663,-0.018364454,-0.039305747,0.058046144,-0.019293731,0.043231178,-0.048486408,-0.0061980677,-0.002671405,-0.061379675,-0.11272779,-0.061936475,0.018505497,-0.10338614,-0.010422356,-0.069770135,-0.08469374,-0.0017272593,-0.028163435,0.018377298,-0.005379333,0.024616374,-0.08996074,0.03980222,0.06428234,0.04980676,-0.01386152,0.008565928,-0.05146664,-0.03534473,-0.059485506,-0.013474766,-0.0026870663,-0.016913014,0.06017192,-0.019856328,0.0443424,-0.009730381,0.024219632,0.0035163467,0.012566724,-0.00906435,-0.051077414,-0.009247226,0.034879804,0.1258018,0.030780207,-0.009658648,0.019000964,-0.034197662,-0.025939675,0.051296186,0.04908351,0.11780019,0.027495515,-0.05482165,-0.005932727,-0.04070346,0.02939482,0.034722574,-0.031710695,-0.07328324,-0.038661662,0.06751569,-0.005214107,0.014677107,-0.043844916,-0.021221492,-0.10672865,-0.0041668057,-0.024517467,-0.07815676,-0.07063072,-0.022388602,0.031898573,0.09439819,-0.033226162,0.06357112,-0.010895259,-0.0042001163,0.11058611,0.12833719,0.05418906,0.04726005,0.06923773,-0.030975401,0.024755642,0.0102819195,-0.03278003,-0.016815646,0.0028784643,-0.005109355,-0.055737842,0.004624304,0.09793918,-0.0625803,0.046294115,0.013115605,0.015965888,0.040666968,0.08764493,-0.042732116,-0.057216782,-0.07149867,0.053371236,0.03405051,0.14689456,0.012227514,0.061570726,0.0143154925,-0.016338646,0.07247589,0.008928586,-0.033925433,0.049002722,-0.00060237944,0.015084333,-0.08978833,0.038571324,-0.01574959,0.03689415,-0.04175275,0.060440227,-0.066913575,0.075586125,-0.04345086,5.5215114e-34,0.046353187,0.04158371,-0.0434346,-0.03163774,-0.018317543,0.0046768975,-0.049785938,0.04275004,-0.025133414,-0.05633725,-0.051196456,-0.06565617,-0.021274116,-0.096263975,-0.07550221,0.027194848,-0.026439749,-0.028696747,0.035494655,0.014939468,0.0033388103,0.033320136,-0.059659082,-0.032046743,-0.017506504,-0.00948399,0.020631522,-0.015719317,0.031712107,-0.06426296,0.018362807,-0.062974036,-0.05680271,-0.0056285793,0.016030412,-0.030274501,0.013041554,0.039869737,-0.029103698,0.058489017,-0.035766136,0.07976772,-0.021192554,-0.011038093,0.008221414,-0.039286,-0.027026497,0.10227232,0.07086332,0.017529307,0.008235477,0.03277756,0.0598024,-0.02572621,-0.08696831,0.014019559,0.058537576,-0.008587719,0.068125516,0.027600853,0.0018650322,0.017185912,-0.008308419,0.0461794,0.025527611,0.0322585,-0.03251249,-0.018639132,0.019085187,0.13286157,-0.14431885,0.049649518,0.07099701,-0.02682501,0.019852202,-0.056535624,-0.04732921,-0.0975966,0.09452831,-0.009672203,0.065323055,-0.043224975,0.03121345,0.008601577,-0.045157034,-0.07888208,-0.03277431,-0.054640844,0.003593142,-0.015711294,0.059633672,-0.067183435,-0.07992342,-0.06405062,0.013275622,-1.1879432e-34,0.09913058,-0.06622826,-0.034571826,-0.09628935,-0.060644202,0.013852187,-0.011606537,-0.06826676,0.008491566,0.008717735,0.10004244,-0.0557594,0.08848996,0.050487027,0.055392068,-0.03821579,-0.016879512,0.08490429,0.069090806,-0.0014137584,0.007410468,0.055676755,-0.04438672,-0.025331434,0.0279709,0.009774401,0.0006845382,0.019567493,0.13077971,0.033223085,-0.026582172,-0.035537567,0.003960674,-0.033544302,0.018628372,0.050148457,0.044147782,-0.00483858,-0.017654292,0.014385831,0.040271215,-0.04108766,0.03492522,0.1133035,-0.034002807,0.055259097,-0.13925062,0.018452099,-0.04725735,-0.027526291,0.047273047,0.06910018,-0.038144264,-0.014746653,0.044743877,0.048122253,0.08349069,-0.023389146,0.0062297597,-0.028343217,-0.053321432,-0.046420403,0.027206508,-0.04004735,-0.0018537429,0.03272699,-0.07365286,0.12630089,0.02492003,0.010902226,-0.02456854,0.045878287,0.114727184,-0.0316096,-0.03479406,-0.018085472,0.07227045,0.00052863394,0.06405884,-0.017447956,0.012289358,0.029423209,0.013904244,-0.04140064,0.012322748,-0.020788524,0.10434496,0.091624804,-0.03237037,0.044333506,-0.030588387,-0.009724379,0.013949043,0.073202685,-0.043721184,-3.4918365e-08,-0.026647098,-0.09888705,0.054040734,0.032887455,-0.013911004,0.09707759,0.076908395,0.0059422874,-0.030697405,-0.01635609,-0.003565248,0.099038124,-0.008571565,-0.03991136,0.07607461,0.03320326,-0.014177825,-0.043687757,-0.04288773,-0.021892982,-0.065811224,0.017019449,-0.06884937,0.011556606,0.0061164987,-0.06324857,0.035054903,-0.0019344463,-0.05797238,-0.0154817905,-0.0730439,0.023087338,0.011864621,-0.03741536,-0.03996337,-0.009440186,7.42938e-05,0.027455678,0.0039991583,-0.12319296,-0.041396078,-0.012841683,-0.05510828,-0.0039242483,-0.0014983697,-0.009558606,-0.029677356,-0.023462474,0.044250496,-4.6490422e-05,0.0487435,-0.037636887,0.094776556,-0.009146497,-0.07292739,0.07298973,-0.030289913,-0.053873062,-0.017486325,0.013716556,0.030250004,0.0322213,0.14324085,-0.020225711 +2.1.1.164,"Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers [1]. The enzyme is a member of the general acid/base-dependent O-methyltransferase family [2].",384,1.0000001,-0.011215306,0.008292945,-0.110023186,-0.04065909,-0.03610352,0.03184681,-0.041185454,0.04271101,0.08796841,0.023935147,-0.028371027,-0.036985274,0.07186471,-0.0316025,-0.06800221,0.097507276,-0.052909173,0.06258349,-0.005546773,-0.0016508505,0.04713676,-0.0076535987,0.02297063,0.028989641,0.10022324,0.040982995,0.013162248,0.065994084,-0.07106059,-0.091724254,0.03202657,-0.045728203,0.034584776,-0.044225246,0.09108747,0.02694807,-0.032504756,0.0061684744,0.12463251,0.022891644,-0.03718409,-0.024033558,-0.022545192,0.028404273,-0.0909298,-0.01675484,-0.023373663,0.024118671,0.05382381,-0.03306634,-0.05372425,-0.059458744,-0.045114465,0.0096327495,0.07980757,-0.06709955,-0.037921425,-0.005317256,0.015305164,0.0010780799,0.089076005,0.0017495768,-0.012278238,0.024862152,-0.07907212,-0.11183542,-0.00038488797,-0.04639381,0.05533874,-0.024642186,-0.087907694,-0.0877359,0.015883394,0.035473473,0.02363722,0.0061870753,-0.01542997,-0.016344734,-0.049149096,-0.026766779,0.049273636,0.008733948,0.06251824,0.078009166,-0.013102056,0.06547708,0.07292759,0.03301181,0.07419899,0.034467395,-0.023311906,-0.0064643263,0.042464778,-0.06363913,-0.06167984,-0.05511881,0.0003209074,0.07079222,0.04178727,0.020492228,0.03069935,0.015953679,5.4116023e-05,-0.043571997,-0.052107003,0.0016677999,0.0031963186,0.06911039,0.041049182,-0.08938365,-0.006260824,-0.029867917,-0.044424348,-0.0062031746,-0.071003646,0.097117774,0.08800092,-0.0758366,-0.121695705,-0.01848631,0.0010247276,-0.021107467,0.029721785,-0.001450512,-0.021905294,0.051451445,-0.053308867,4.428272e-33,0.045124326,0.107841544,-0.048740324,-0.029564291,-0.0044111814,-0.03049889,-0.093274295,0.008091921,0.016336037,-0.052725412,-0.1438438,-0.06207746,-0.04101924,-0.013660546,-0.0021230227,0.020710418,-0.05901745,-0.009904916,0.031966787,0.06429971,0.02887223,-0.014324421,-0.07745161,0.011604757,0.012992499,0.053739626,0.03469641,0.035521094,0.040843893,-0.020417662,0.026254006,-0.02722236,-0.08369478,-0.018378615,0.050833613,-0.018413175,-0.021662902,0.016457908,0.05556278,0.09370751,-0.04540418,0.023747293,0.059221007,0.0115535045,0.015967706,0.016165605,-0.03015065,0.10281706,0.10336154,0.028680462,0.003488387,-0.022410464,0.11280965,0.069776036,-0.0887759,0.04254986,-0.028823836,-0.024144216,0.011978017,0.029339796,-0.0066774935,-0.019695284,0.031100828,-0.019660084,0.05502123,-0.03242583,-0.022751039,-0.017013224,0.013851044,0.0719982,-0.049269915,-0.0059549087,0.11937408,0.032658808,0.039154097,-0.01761841,0.017798522,-0.025517045,0.051160812,0.028527245,0.042927254,-0.014256096,-0.027027564,-0.10360299,-0.022259368,-0.027701767,-0.06536631,-0.07403504,-0.04536226,0.13069445,-0.04046992,-0.06377417,-0.07279754,0.003704304,-0.013885757,-6.076226e-33,0.12299379,-0.06697182,0.03816833,-0.06947875,0.0038923966,0.059272055,-0.0003490734,0.028956255,-0.021881606,0.032094702,0.03270564,-0.009776251,0.06660826,0.020125981,0.022781165,-0.053123046,-0.015739117,0.10567693,-0.042988326,-0.008854695,-0.03016644,0.08734679,-0.08709778,-0.032446936,0.053692013,0.046435934,0.02098745,0.076270565,0.040115204,0.043470353,0.0367594,-1.002746e-06,-0.06273315,-0.06923589,0.003289464,0.12416534,-0.044529106,0.012956627,0.018340802,0.0046000765,-0.0070097293,0.018525215,-0.02431629,0.04607838,0.09450279,0.024542877,-0.054169077,0.09362068,0.03384961,-0.06596753,0.029843904,0.023132645,-0.039717972,-0.008530756,0.03250189,0.0360149,0.07498893,-0.038716912,-0.026844686,-0.023565141,-0.09282127,-0.061171614,0.04978562,-0.019509938,-0.03591312,0.06730735,-0.011351285,0.014424999,0.0527791,0.024996366,0.0049146516,-0.055315237,-0.028790602,0.030155754,-0.010191902,0.0025013096,-0.057731997,-0.07844365,-0.019818313,-0.010371386,-0.021744087,-0.0009186211,0.08016436,-0.051592782,-0.009001089,-0.016235208,0.024427695,0.016629895,-0.024233894,-0.009037156,0.05614075,0.019919368,-0.026715536,0.062612146,0.00085231615,-4.5416684e-08,0.100744374,-0.059288416,0.06571014,-0.04729995,-0.005469884,0.046508797,-0.037200887,-0.031823013,0.028981393,-0.032358434,-0.019799745,0.08219507,-0.015618055,-0.016979702,0.010501073,0.0141154025,-0.02494803,0.052651085,-0.018041542,0.013974099,-0.10461917,-0.055571716,-0.08115581,0.02820356,-0.0018431223,-0.033406872,0.014920868,0.024650296,0.031236354,-0.025165297,0.05762701,0.09153381,-0.06959655,-0.038269684,-0.07951209,-0.067011856,-0.047431204,0.001212206,-0.017859107,-0.060490433,0.06586092,-0.059008744,-0.109815836,0.046836447,-0.054950636,0.0058879163,-0.029742895,-0.040190592,-0.06822171,0.00019181213,0.03719183,0.011051699,-0.029875107,-0.03846636,-0.11706734,-0.0037386536,-0.039058514,-0.034100693,-0.028039768,-0.078481056,-0.06890336,-0.0188939,0.14403577,-0.058914084 +2.1.1.165,This enzyme contributes to the methyl halide emissions from Arabidopsis [6].,384,1.0,-0.013142867,-0.022541635,-0.03614493,-0.008699005,0.09746722,0.045468986,-0.049792957,0.0047345078,0.049546957,-0.00801745,0.05446444,-0.06350348,-0.07714856,-0.028511463,-0.013340357,0.11347082,-0.041343436,0.060714144,-0.08712786,-0.041858897,0.088492595,0.07406226,-0.021776943,-0.01915486,0.012177575,0.01342341,-0.008917866,-0.04548792,0.02659361,-0.047611818,0.015474148,0.10684356,0.07197883,0.023684882,0.07659387,0.059735693,0.07146636,-0.08863114,0.006256605,0.009066981,0.018651094,-0.028787185,-0.008048624,-0.06766359,-0.12800938,-0.0510466,0.012878438,-0.029692588,0.049200803,-0.05860434,0.043473575,-0.03431152,0.013719398,-0.03380313,0.031706057,-0.0021997304,-0.018535068,-0.021971114,-0.015154975,-0.04373879,0.016881889,-0.04977303,0.0051595764,-0.004335504,-0.013420645,-0.0057339217,-0.04566894,-0.035181396,0.0022098133,-0.09941443,-0.049828485,-0.08758321,-0.10588877,0.005996742,0.014456635,0.049376354,-0.017589524,-0.02609208,0.049051248,-0.07744454,0.01198997,0.043208394,0.05582891,0.030438766,0.06928526,0.015107946,0.026604109,0.07827189,-0.010249856,0.03743855,0.032409318,-0.025645422,0.041923866,-0.019534882,-0.043403562,0.079881206,0.018314347,-0.068177395,0.0047906805,-0.0368163,-0.007231463,0.059280064,-0.17330387,-0.07013917,0.0042448076,0.026347639,0.049189873,0.08813809,-0.05012843,-0.0061326195,0.006183391,0.039576616,-0.019728877,-0.010455069,0.023252865,0.02687309,0.099737324,-0.010731552,-0.0698114,-0.03044895,-0.059306,-0.014994021,0.0005992189,0.06418188,-0.06604262,0.015369634,-0.11524321,-3.3835507e-33,0.027179936,0.03771545,-0.029751247,-0.10028332,0.0070970627,-0.038576357,-0.009391127,0.037020195,-0.041044574,-0.0776259,-0.075314105,-0.049947064,0.04399765,-0.02686829,0.013070362,-0.049279567,-0.019703342,0.0064834426,0.018801572,-0.04550261,-0.032341357,-0.038713135,-0.05925605,0.010492712,-0.050128754,0.0048382394,0.06398482,0.0056515485,0.04169522,-0.016261274,-0.05178701,-0.062149394,-0.0340094,0.0064056446,0.06625051,0.054556012,-0.005015268,0.017824419,-0.07639471,0.034482267,-0.031155169,0.037894614,-0.038586017,-0.045211527,0.039502356,-0.0045984527,-0.07770913,0.064126864,0.08018608,0.036567334,-0.013339322,0.032412253,0.079405725,-0.027634837,-0.044046257,0.036655277,0.028284453,-0.04748984,-0.06803675,0.030125143,-0.115644105,0.02140551,-0.018980721,0.08900755,-0.0013970211,0.039620385,-0.07064987,-0.063384876,-0.027466057,0.1675972,-0.06844303,-0.05303388,0.021898992,0.054128,-0.014436323,-0.011769146,-0.06458146,-0.0076901354,-0.0039777146,0.08257804,0.072181076,0.0031923926,0.05299492,-0.079333045,-0.11331874,-0.063942,-0.056045856,-0.048709802,-0.013836027,0.016853377,0.121696405,-0.045826185,0.018519212,0.027652372,-0.021752205,1.1076518e-33,0.07044404,-0.0037688205,0.08108324,-0.10868207,-0.03744027,0.08778725,-0.0033673542,-0.030317271,-0.029290162,-0.0020494515,0.07915163,0.05896489,0.0024549463,-0.033326034,0.009916364,0.01800092,0.062566675,0.086994626,0.028636415,-0.0012350766,-0.03773496,0.0602291,0.057401,0.054611728,0.0021063194,0.017185075,0.05197121,0.10255085,0.07337279,-0.023664359,0.006684996,0.051213685,-0.0573931,0.005782186,0.036560506,0.01658868,-0.03775844,-0.02292735,-0.008258594,0.0056043416,-0.06298218,0.0045857937,-0.0019029562,0.092543274,0.057973918,0.033547923,-0.030538071,0.024895163,-0.014831428,-0.032172803,0.01704427,0.04206336,-0.0066608745,0.11271289,0.0064630546,-0.0029037553,0.08442112,0.023563394,-0.027331414,-0.005991034,-0.02551385,-0.00477829,0.011502347,0.015088201,-0.0071125487,-0.004224051,0.031805474,0.021256676,-0.015511398,0.0006567185,0.06909194,0.022218682,-0.0073420103,0.04257733,-0.07449896,-0.054862384,-0.055611886,-0.047066458,-0.063023046,0.03917582,-0.06576675,0.074773885,-0.061202306,-0.06195237,-0.0033653157,-0.09360922,0.02750169,0.080898784,-0.00324511,0.059539225,-0.0521859,-0.0062237717,-0.08303473,0.09121597,0.072629996,-2.1124228e-08,-0.039428163,-0.12157184,0.019948501,-0.05804797,-0.033346582,0.073608644,-0.011786445,0.0066004544,0.030343102,-0.021615611,-0.0069483244,0.01924412,0.008593671,0.07871202,0.030166455,-0.02109978,0.03141025,-0.03703357,0.049698565,-0.0113573475,-0.03185449,0.004735,-0.05707587,0.015134309,0.0009807603,-0.014217312,0.03365018,0.10448935,0.063818306,-0.0003954151,0.07163405,0.05006676,0.01773233,-0.012843602,-0.121094435,0.059978835,0.018845303,-0.055080775,-0.02353117,0.03897334,-0.005936184,0.026535563,-0.05420312,0.016289435,-0.040157065,-0.001282267,-0.023159886,0.0661066,0.012559358,0.05006069,0.06989204,-0.06911843,0.016628578,-0.06542898,-0.09446089,0.0166351,-0.0104652215,-0.09397547,0.020005133,-0.006005349,0.0655538,-0.023008466,0.123517886,-0.04468686 +2.3.1.189,"This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium [1]. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs) [2]. The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate [3].",384,0.99999994,-0.05432918,-0.038297582,-0.109602086,-0.042260006,0.064344995,0.005797945,-0.03197237,0.09048028,-0.029510144,0.02666949,0.011735836,-0.067636184,-0.0014659544,0.030308215,-0.074550755,0.02876812,-0.0036547605,0.0092509305,0.015504812,-0.069081105,0.031205853,0.12080753,-0.010793215,-0.019299747,0.070576735,-0.04254344,0.0192159,-0.007142592,-0.048074763,-0.14978816,-0.03683626,-0.06454322,0.07072768,-0.029406788,0.0662545,0.10359544,-0.09776359,-0.05437997,0.14677556,-0.04255414,0.050878625,-0.0753979,-0.0043986305,0.01617064,-0.042957734,0.0019170657,-0.025970945,0.0563435,0.0018081251,0.045737695,-0.057926923,-0.054917686,-0.016653948,0.06914282,0.03074739,0.012793272,0.0064428695,-0.044832177,0.018065711,0.07600378,0.060686067,0.0058641834,-0.051238623,-0.024011659,-0.0030041628,-0.009478343,0.02068012,-0.018215755,0.036271065,-0.025012769,-0.044316728,-0.023026064,-0.062813334,0.080894925,-0.02525188,-0.025894566,-0.03884377,-0.02914035,0.02535928,0.026008494,-0.040267404,0.030264255,-0.0059509496,0.00956,0.0181784,-0.027654467,0.058647946,0.033938266,0.036925986,0.05312227,0.05202211,-0.03537202,0.01671113,-0.050577912,-0.0865743,0.036298703,0.093354374,-0.0077926065,0.04073684,-0.036172915,0.056170918,-0.004011845,-0.0070990636,-0.05701486,-0.055095773,0.014953874,-0.0043244045,0.06306791,0.07573156,0.007207125,-0.052095793,0.00938298,-0.013695594,-0.033639252,-0.024527194,0.07210754,0.047169752,-0.0217866,-0.070764296,0.026597092,0.01948824,0.019498842,0.038802844,0.029401908,-0.068817794,-0.0070655467,-0.0685297,4.666188e-33,0.026424471,-0.0070297644,-0.0045316336,0.0014653312,0.06577756,-0.020882752,-0.090333216,-0.00920103,-0.0056815357,-0.061663453,-0.06230698,-0.12655991,-0.04412768,0.017495347,-0.10543412,0.014316084,-0.05288982,-0.031612493,0.07796473,0.11568413,-0.007036278,0.000101652986,-0.066809624,0.037250392,0.0014073077,0.046063717,-0.0164293,0.08025605,0.048274156,0.0001740477,0.03561376,-0.060389057,-0.08178792,-0.0011128839,0.06270859,-0.0565691,-0.014857192,-0.059193086,0.016608251,0.025358496,0.0087309135,0.03751241,0.006088449,-0.028679293,0.0587984,-0.015408322,-0.039704423,0.06534041,-0.021676837,0.027129147,0.09120823,-0.057684403,0.12059983,-0.045153227,-0.0004587255,0.003882702,-0.03350873,0.052640792,0.046812743,0.04677161,0.06413787,0.06311047,-0.000502288,0.08687736,-0.058830395,-0.013338578,-0.06602857,0.01936906,0.056875233,0.039038077,-0.0018381657,0.016679896,0.012965824,-0.022537692,0.07373188,-0.02527162,-0.06149289,-0.020370277,-0.009706122,-0.051397208,0.048460554,0.05386505,-0.014942754,-0.069287606,-0.00040857238,0.0134391,-0.02545869,-0.069978155,-0.022400325,0.019576734,0.015698647,-0.06609592,-0.026964031,0.060433168,-0.0019069685,-4.5310642e-33,0.13891844,-0.13034174,0.14571671,-0.06790487,-0.07387213,0.04142847,0.025800362,-0.011102406,0.039095473,0.05277352,0.067325495,0.015649986,0.0032465674,-0.03204152,0.042784944,0.0069988477,0.04449619,0.039740108,-0.00058799615,-0.016204936,-0.054083306,0.06972741,-0.019225383,-0.059429113,0.018731771,-0.0040218225,-0.06430991,0.10325534,0.08361755,0.07382375,-0.010121394,-0.021964017,-0.04132213,-0.06818338,-0.054786325,0.00992578,-0.04276156,0.036002394,0.039758425,-0.059988994,-0.038592603,0.053908434,-0.005320009,0.011535622,-0.030996302,0.040357847,-0.060761448,-0.015080172,-0.034350753,-0.07940798,0.012789381,-0.019801494,-0.021890894,-0.024098078,0.0106508145,0.04987627,0.040017385,-0.019016126,0.061985437,-0.08997009,-0.05359465,-0.006993076,-0.005476046,-0.026022222,0.06998201,0.080761835,-0.06567238,0.106831536,0.053649627,-0.004373026,0.05618587,0.029748295,0.0059660203,0.059079647,0.016383607,-0.031608745,0.016717432,0.037280627,0.0047684386,-0.00046464993,0.014779512,-0.00914654,-0.030138465,-0.1277753,-0.062494904,-0.09874394,0.069477804,0.14110182,-0.023417817,0.10517633,-0.03228084,0.089011915,-0.046606913,0.026624566,0.05240836,-3.9495696e-08,0.041774735,-0.06534482,0.024762515,-0.06882989,0.06209753,0.026817229,-0.03404649,-0.016654367,0.102340475,-0.0006099125,-0.02387612,0.07328271,0.07174164,-0.0017581221,0.021311434,-0.0065088426,0.007974418,-0.034017965,0.027376939,0.021337438,-0.07154639,0.027868217,-0.028911522,0.029920736,-0.00045307569,-0.048064843,0.019007295,0.021554144,-0.014259263,0.02183872,-0.004915608,0.045640815,-0.030542735,-0.08705827,-0.08089227,0.041550975,-0.07270203,-0.078012146,0.04264613,0.02300879,0.02367311,-0.06916784,-0.035962664,0.022107573,-0.06985616,-0.060630746,-0.02197944,0.005100665,-0.012840484,0.009166972,-0.008943187,-0.019109283,-0.04609806,-0.03787088,-0.011628339,0.019667417,0.056750398,-0.029860962,-0.06484695,-0.050075226,0.038605653,0.014870986,0.15295814,-0.04250099 +2.4.1.250,"The enzyme, which belongs to the GT-B fold superfamily, catalyses the first dedicated reaction in the biosynthesis of mycothiol [1]. The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate [2]. A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate [3].",384,0.99999994,-0.0838697,-0.082169026,-0.07682329,-0.02023815,0.06737522,-0.09516067,-0.03478654,0.07856526,0.040007357,0.036061667,0.04982775,-0.03306678,-0.047578987,0.029153952,-0.052491512,0.10200446,-0.035429705,0.036077,-0.029059215,-0.06675068,0.0732394,0.06569325,-0.0044172746,0.025781473,0.047589257,-0.044292662,0.065685764,0.025203273,-0.0038962434,-0.09919601,-0.12756477,-0.037383053,0.07754572,-0.08063833,0.062502235,0.14856383,-0.06786066,-0.038611356,0.05046538,-0.06419146,0.03303465,-0.03505073,0.045400184,-0.0004818714,-0.03332452,-0.015822489,-0.053333886,0.07083791,0.012844462,0.0035094435,-0.011492593,0.0010490937,0.008214344,0.0050679795,0.0065281847,0.050550207,-0.03239733,0.022047948,-0.05052234,0.09477081,0.039369054,-0.013017069,-0.033632275,-0.018424775,0.00807982,0.008808006,0.017809702,-0.03967498,-0.01921375,-0.021563709,-0.055433042,-0.051701345,-0.03877455,0.05301144,0.04002813,0.04146357,-0.009482268,-0.0034902233,0.03451158,-0.012685492,0.06397171,0.027079895,0.051352262,0.027149374,0.0011113985,-0.0026208598,0.02093653,-0.0016795101,0.042735312,0.06721566,0.038993444,-0.038237482,-0.07289358,0.019851912,-0.078264415,0.014459946,0.09940703,0.033047095,0.026826782,-0.03541967,0.029661767,0.029076086,-0.056745782,-0.037668128,-0.05988895,-0.009596551,-0.029875904,0.021787008,0.037819907,0.02035877,0.036702365,-0.031650644,0.044024162,-0.009656815,-0.05379823,0.10056492,0.0033332324,0.008186392,-0.056741364,0.052613422,-0.014120577,0.015184725,-0.046632115,0.009930392,-0.14834283,0.017738258,-0.06816351,-4.7910105e-34,0.041735128,0.049555518,-0.07802299,0.043456208,0.023773218,-0.05952464,-0.052591782,-0.048910122,-0.15033746,-0.0074201273,-0.05427401,-0.06709685,-0.041078307,-0.014975428,-0.08197302,0.040776584,-0.0049081,-0.026662959,5.2637562e-05,0.04367236,-0.045545507,0.080459386,-0.078517556,0.0035710612,0.011835551,0.074494466,-0.099884026,-0.030482423,0.052795798,-0.0017500167,0.00388456,-0.038590945,-0.1641967,0.053499803,0.029510949,-0.08610496,-0.0027162144,-0.117949404,-0.046461876,0.06618862,-0.022059655,0.05163258,-0.006187722,-0.054815594,0.031639744,-0.031815212,0.051232174,0.055738334,0.0075081857,0.00588844,0.058569957,0.019031987,0.087494515,-0.03597202,-0.056726165,-0.025068432,0.010157287,-0.042023905,0.05344559,0.10657967,-0.013051258,0.05329727,-0.0067173783,0.0998147,-0.047629647,-0.024206484,-0.080414034,-0.045932684,0.01135937,0.07669076,0.01359799,0.018320715,-0.044451702,-0.021637099,0.02231023,-0.024590915,-0.042019162,0.023731636,-0.01654925,-0.0091147255,0.04117089,0.066589125,-0.011956932,-0.04340497,-0.035848614,0.00999391,0.0068612415,-0.027425928,-0.024218911,0.041795142,-0.0374266,-0.0065237954,0.011670779,0.032374874,0.041154314,-2.064012e-33,0.07116969,-0.084577724,0.12757601,-0.07619759,-0.090156,0.04675076,0.038471654,-0.051535618,0.06701615,0.011484236,0.036351845,0.028865056,-0.001804659,0.019533891,0.0053876755,0.013716423,-0.00050979084,0.05439755,-0.02669895,-0.047198664,-0.0019113534,0.08112334,-0.007939577,0.03058334,0.022377832,-0.025128648,0.031870294,0.054389894,0.08336335,0.07920692,-0.008879284,0.00299886,-0.014012089,-0.016134769,0.014218115,0.059429023,-0.06470543,-0.051290147,0.05153976,0.014095775,-0.060376123,0.081213385,0.00752171,0.02297447,-0.02883509,0.016758254,-0.080877624,0.06725089,-0.011982332,-0.10428266,-0.015203795,0.014962738,0.05030828,-0.033168558,0.0073687322,0.029960511,0.01362408,-0.03141323,0.015598272,-0.02651068,-0.021454604,-0.055784896,-0.048567068,-0.0009529933,0.022602545,0.109170794,0.016230395,0.009007087,0.060653273,-0.012036817,0.049754675,0.0013789224,0.018974924,0.059389498,0.015733205,-0.00993799,0.00236261,0.019964153,0.07549038,-0.01168273,-0.012249705,0.040130306,0.03089471,-0.08006783,-0.007601005,-0.14123292,0.07779349,0.16878887,0.018040108,0.06953962,0.039633412,0.07107985,-0.05098729,0.07004479,0.03768281,-4.356114e-08,0.07771014,-0.06564412,0.051714495,-0.019415822,0.01716498,0.025155043,0.01927644,-0.036296885,0.05057591,0.028547307,-0.05880019,0.04413979,0.029190257,-0.008470574,0.06345335,0.001600041,-0.0010835605,0.016131833,-0.020296162,0.036156345,-0.062544346,-0.017373784,-0.064165734,-0.060701102,0.025512382,-0.088215746,-0.017041279,0.020650245,-0.016501807,0.023102392,-0.002706344,-0.0037369176,-0.04992418,-0.04925673,-0.06999817,0.02547832,-0.11566068,-0.081418045,0.012329655,-0.02167925,0.054915976,-0.10772145,0.026865251,0.020827543,-0.08048428,0.003036445,-0.031644486,-0.013394247,0.0037245993,0.07458558,-0.023398729,-0.040519215,0.025762042,-0.02544796,-0.025532966,0.009398133,0.04121502,0.026361084,-0.037744656,-0.082755886,-0.05638965,0.039968602,0.08585221,-0.081743576 +2.4.2.42,"The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains [2,3]. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.",384,0.99999994,-0.038793445,-0.045244664,-0.08695329,-0.04802107,-0.032330237,0.05481477,0.04980542,0.035437472,-0.0026998715,0.121974714,0.09413226,-0.07100138,-0.07688792,0.026717572,-0.016721623,0.03259577,-0.04639798,0.018330596,0.0013083038,-0.12450656,0.026111592,-0.0074446476,-0.0055961013,-0.00017091942,0.025762286,-0.04871788,0.0063673793,-0.02446366,-0.009943117,-0.08083511,-0.041068237,-0.013295773,-0.0007290574,-0.05286584,-0.010296889,0.03286453,0.006909261,-0.055144046,0.026493084,0.028712925,0.060571216,0.009183564,0.0030243527,-0.019021388,-0.033874065,-0.0020300846,-0.040658925,0.101991296,0.050023306,-0.01223646,0.029402645,-0.07919496,-0.037927117,-0.017192228,0.0024955575,-0.0024315857,-0.037735716,0.0074322196,0.033846777,0.07607889,0.010007978,-0.04007846,0.021208385,0.05362028,-0.036828145,-0.08948479,0.038663562,-0.06646316,-0.07069855,0.013700519,-0.044477113,-0.074143015,-0.038616758,0.0100446185,0.035505366,-0.0118462285,-0.03880907,0.04245965,0.0242754,0.039359264,-0.010726458,0.054138415,0.06461735,0.08344304,-0.011167067,-0.017522482,-0.03283303,-0.05970507,-0.055550903,0.074627586,0.06562132,-0.0513725,-0.015500364,0.06794748,-0.024220837,-0.010298956,0.028280808,-0.08749076,0.019738311,-0.064975604,-0.07525915,-0.018196367,0.032448985,-0.025755247,-0.018541696,0.03381923,-0.04424816,0.051977422,0.046369165,0.025170745,-0.058163088,0.0075954297,0.033309728,0.04516718,-0.082000576,0.041951794,0.006094597,-0.11013653,0.06994315,-0.044502556,0.038768142,0.0045339684,-0.016374925,0.056421243,-0.0656829,0.005394031,0.003815764,-1.791394e-33,0.07557071,0.028622236,-0.06441482,0.0046901545,0.023031378,0.04456005,-0.04893354,-0.016163936,-0.08828247,0.016520776,-0.061525457,-0.0495566,0.07875462,0.14368886,0.020268314,0.06354192,0.014639036,-0.049407117,0.059256166,-0.012248883,-0.08445326,-0.0032704324,-0.024043178,0.022651369,0.061442845,0.13904189,-0.04803082,-0.004512308,0.03937472,0.0057468214,-0.00015223118,-0.03970503,-0.022269987,0.0346217,0.067415416,0.014389112,0.07443491,-0.03824373,-0.030177731,-0.0021359092,0.12350117,-0.02538258,-0.041133888,-0.07021195,-0.024695966,-0.087456554,-0.04920089,0.07370736,-0.04707359,0.06117205,0.11611344,0.06962819,0.13235576,0.077029146,-0.054711256,0.061978575,-0.09656413,-0.040839735,-0.0105162915,-0.0071649505,-0.064658634,-0.024184104,0.0479296,0.0547913,0.057860307,0.037325107,-0.022417504,-0.101459175,-0.024783934,0.01067864,-0.0057290774,-0.08322245,0.052201588,-0.027437057,-0.047818147,-0.03847493,-0.06470617,0.07706663,0.03997104,0.021136314,0.08750629,0.056594178,0.05338695,-0.02771014,0.02498167,-0.060053106,-0.049944352,-0.026090555,0.017202022,0.0064962655,-0.044349246,0.0014504842,0.008912577,0.11950369,0.023280764,-1.6225868e-33,0.06857422,-0.05179319,0.04900282,-0.051753897,-0.027932001,0.082541324,0.006140271,0.010663628,0.034542054,-0.016282177,0.07083799,0.042972725,-0.053520087,-0.026198411,0.036774654,0.011777754,-0.029578872,0.029069468,-0.039600685,-0.053929742,-0.014819786,-0.028112102,0.00077345263,0.0014878655,0.015836759,-0.01660388,-0.038634352,0.0021912816,-0.045711566,0.016410407,-0.005542681,-0.06660982,-0.04351298,-0.05540459,0.015192828,0.01823819,-0.008013542,0.020027159,-0.008122102,-0.004554769,0.07337926,0.028197477,0.09781281,-0.028948346,0.0896643,0.06337937,-0.017264344,0.076381035,-0.07386327,0.030643947,-0.006148564,0.07466287,0.07166619,0.059792906,-0.014370813,0.08377279,0.03415379,0.0065074763,-0.0113124205,-0.026942527,-0.022110023,-0.101536304,0.027595328,0.050683018,0.042875715,0.005862174,-0.023360765,-0.053379267,0.013782384,-0.0104797315,0.086339645,-0.0022506996,-0.04504625,-0.024738293,-0.12701139,-0.01530735,-0.03801996,-0.026355805,0.010850595,0.06013921,0.008223429,0.024447143,0.028980501,-0.037368506,0.015318307,-0.005837664,-0.05894391,0.12285632,-0.0032313582,-0.037548307,-0.027612334,-0.09848997,-0.10703222,-0.02435214,0.0720492,-3.7359083e-08,0.04650147,-0.023658425,-0.045840923,-0.07097259,-0.016639676,0.028542476,0.025358379,-0.0021366107,-0.040520977,-0.017484661,0.037959855,0.054037973,-0.05876351,0.10179849,-0.010740158,0.0012547723,0.07266989,0.08391284,-0.007240805,-0.03953413,-0.07639747,0.027272103,0.030135803,-0.008179242,-0.07532068,-0.15697351,0.01663256,0.06968914,-0.04104532,0.014998839,-0.008592382,0.05870056,0.009649292,-0.05369943,-0.035811428,-0.03409766,0.0058735963,-0.042063892,0.014614988,-0.02855685,0.019817758,0.028278979,0.023531513,-0.048403192,-0.053165793,0.02962281,0.10150063,0.047128092,0.009261852,0.06058268,-0.031687442,0.049153592,-0.050011255,-0.114276335,-0.13294989,0.009316741,-0.0049635232,-0.008475226,0.008158151,-0.044680536,-0.009555666,-0.039775547,0.06580455,-0.016611736 +2.7.7.68,"This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor, in all methanogenic archaea. cf. EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase and EC 2.7.7.106, 3-phospho-(R)-glycerate guanylyltransferase.",384,0.99999994,-0.008851799,-0.00048150244,-0.1213849,-0.01726598,0.05095506,0.012453101,-0.112533346,-0.011079109,-0.042018484,0.00081103074,0.0012054499,-0.09067887,-0.04083879,-0.011662851,-0.049208663,0.0042264075,-0.046658106,-0.018346941,-0.018013187,-0.060631678,0.09462186,0.07439975,-0.048826996,-0.014008984,-0.031096721,-0.005792718,0.004248442,-0.052745916,-0.0063651246,-0.056829013,-0.029432938,-0.052216884,0.10755872,-0.02815941,0.051592782,0.14605819,-0.0358005,-0.06758021,0.06768321,0.01300466,0.009988644,0.0408394,0.090031005,0.009290546,-0.031060752,0.04957726,0.04939181,-0.017274024,0.03401555,-0.03566688,-0.05255377,0.022419179,-0.07181609,0.06327149,0.05737579,0.09258492,-0.008934708,-0.110511936,-0.033878475,-0.0357525,0.060789157,-0.019969605,0.046845764,-0.003376212,-0.03031369,0.005549212,0.08380038,-0.07137852,0.050695572,-0.056493327,-0.069033474,-0.01052978,-0.027873851,-0.050127167,-0.043404266,0.025178509,-0.02255558,-0.016737372,0.042699967,0.0016232233,0.057188258,-0.022778634,0.0638746,-0.03216797,0.054842442,-0.052647352,-0.013374009,-0.06363297,0.02645681,0.013743514,-0.0033690913,-0.026971688,0.04488496,-0.01803835,-0.11031687,0.029708067,0.049468692,0.010599132,0.008805467,-0.022416884,-0.024682513,0.053446576,-0.00076146313,-0.040661372,-0.09211877,-0.017155237,0.006741221,0.14045955,0.03876559,0.064168945,0.004425217,0.01488017,0.089288555,0.00033550075,0.008479895,0.0889392,-0.006536966,-0.07637716,-0.02800296,0.060117953,0.036276948,-0.0064739557,0.051890872,0.012113021,-0.0571581,0.028954316,-0.1439836,4.3270707e-33,0.09363121,0.06949615,0.005453671,0.010738355,0.035241384,-0.008593965,-0.108306,0.015367042,-0.052013893,-0.02980679,-0.061572615,-0.052771818,0.0644628,-0.002965841,-0.059799183,-0.009685375,-0.038465243,-0.05879167,0.03123204,0.014993377,-0.027556531,0.043533787,-0.017744666,-0.01340422,0.057239123,0.023283513,9.88133e-05,0.013899666,0.03415874,0.003697431,-0.0043655615,-0.0999627,-0.113733,-0.0036852616,0.05325188,-0.037908897,-0.065236285,-0.057464644,-0.07487359,0.019372825,0.008690064,0.05304979,-0.024113331,-0.043592416,0.08015023,-0.023947144,-0.0034283407,0.13143662,0.082006216,0.12557447,-0.017514458,-0.013756796,0.061424125,0.0054050926,-0.07929496,-0.030633029,-0.041424233,-0.033908594,0.035003424,0.054326765,-0.007777084,0.035945866,-0.0017879343,0.05454568,0.011578651,0.06423187,-0.035411607,-0.016751386,0.0137787955,0.101045094,-0.025417421,-0.019831441,0.034574036,0.02629774,0.009704993,-0.07640907,0.021090375,-0.11342597,0.02981075,0.0024217633,0.012825705,0.005975449,0.0049871444,0.011943293,-0.025449803,-0.009476958,-0.025209043,-0.0106405895,0.04925992,0.05344046,0.04543526,-0.049095128,0.022186564,0.025335157,-0.002808236,-3.6868862e-33,0.100721285,-0.109191515,0.0012479984,-0.09498986,-0.03273324,0.047711708,-0.0015636983,-0.011340338,0.022943016,-0.02976883,0.12334918,0.01583273,0.06731309,-0.03443522,0.04116288,-0.020864824,0.060130466,0.04298231,0.015429757,-0.0013515679,0.077990435,0.04164725,-0.020847011,-0.045398027,0.036377706,0.023117721,-0.021216655,0.061869424,0.0047322325,0.04910092,-0.04952474,0.0035297784,-0.07670647,0.004475394,-0.12404185,0.0038003125,-0.0762421,0.039089676,0.0091271205,-0.02303529,0.038617097,0.1026309,-0.007293709,0.041510664,0.042642843,0.055474814,-0.074954435,0.0057890303,0.044575553,-0.03230142,-0.035212092,-0.04635297,-0.08078798,-0.039370045,-0.014177952,0.0533831,0.0114647625,0.041001968,0.0047962605,-0.009699977,-0.04806251,-0.05791644,0.04882953,-0.01505934,0.11143896,0.066214904,-0.00082705886,0.05971421,0.033785824,0.055664558,0.05400708,0.025255345,0.0141759105,0.081527635,0.03831458,-0.040693168,-0.096433945,-0.01726403,-0.026057698,0.019926667,0.04372105,-0.015750915,0.06642071,-0.050812125,-0.053369485,-0.13468099,0.03494114,0.058722038,0.021692393,0.028247224,-0.065684445,-0.022395346,-0.038250994,0.003151321,0.05398699,-3.7761996e-08,0.021441337,0.013737503,0.018544631,-0.06402366,0.022169314,0.108455814,0.045501754,-0.016572054,0.019392168,-0.03294374,0.024404053,0.057667404,0.059538703,0.003745978,0.014230908,0.057680264,-0.03793954,0.012446041,-0.013265912,0.018496394,-0.043280516,-0.026271135,-0.06799309,0.06255621,-0.03487363,-0.064881556,0.066628456,0.049731366,-0.03944544,-0.08933782,-0.04838623,0.025008498,0.049255803,-0.033111665,-0.14046128,-0.011948151,-0.009239244,-0.004940478,-0.057549495,0.01883773,-0.010876978,-0.0067046885,-0.06680343,0.024030257,0.048445422,0.01314059,0.015093635,-0.011589699,-0.011560632,0.009717342,0.06512512,-0.0095234085,0.03805891,-0.013722035,-0.089224525,-0.06641553,-0.012169573,-0.017822795,-0.04298786,-0.017514786,0.050571732,-0.011576124,0.13721773,-0.082130365 +2.7.8.28,"This enzyme is involved in the biosynthesis of factor 420, a redox-active cofactor, in methanogenic archaea and certain bacteria. The specific reaction catalysed in vivo is determined by the availability of substrate, which in turn is determined by the enzyme present in the organism - EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase, EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase, or EC 2.7.7.106, 3-phospho-D-glycerate guanylyltransferase.",384,0.99999994,0.00032022316,-0.03321346,-0.08416719,-0.027340189,0.06812967,0.041346896,-0.06051025,0.018523442,-0.027410505,-0.025379406,0.046887457,-0.039803546,-0.041779805,0.0020412502,-0.056469165,0.017202144,-0.022047762,0.007255301,-0.04549884,-0.098136276,0.07227576,0.065147914,-0.047365185,-0.058942664,0.03526781,0.004355202,0.029847508,-0.06763486,0.0060537998,-0.06328295,-0.051302604,-0.014603589,0.03643037,-0.04711781,0.029636383,0.15136877,-0.040134016,-0.08297312,0.041715432,0.011924067,0.06841145,-0.00647627,0.07261496,0.05092476,0.015494824,0.056868337,0.03650461,0.038706817,-0.0050316085,-0.03970589,-0.061164524,0.022819132,-0.034568515,0.028739188,0.062142327,0.020124665,0.0072265244,-0.06788067,-0.02035026,-0.03321785,0.019778697,0.0049744053,0.04091543,-0.038681805,-0.040035553,-0.023465179,0.10883381,-0.09945355,-0.019705117,-0.048910454,-0.09425657,-0.03701503,0.006486017,-0.019570373,-0.05928051,0.060154196,-0.020228526,-0.032025155,0.044602923,0.031648733,0.07664401,0.020916525,0.07417724,-0.021190345,0.010864398,-0.06225971,0.052747723,-0.0357367,0.025632625,0.03515232,-0.016809592,-0.038712185,0.016367612,-0.025546322,-0.0944383,0.030091517,0.00439406,-0.021596402,0.0077204774,-0.045529064,0.0074087298,0.054197766,-0.044986304,-0.05133431,-0.098310046,-0.046217233,0.022974188,0.1467285,0.049815264,0.031093488,0.023750724,-0.0133418115,0.05128364,0.02463374,0.035505712,0.0748485,0.035651557,-0.08839739,-0.06215003,-0.009997283,0.029549105,0.009185379,0.09907914,-0.01728748,-0.107244246,0.05920764,-0.10741014,4.5418005e-33,0.10131327,0.032603417,-0.011007235,0.0036601124,0.040415857,0.021681163,-0.12345824,0.021373866,-0.0526388,-0.019764112,-0.082107104,-0.084928066,0.014053309,-0.0016026585,-0.0610364,0.053320333,-0.04645184,-0.06983134,0.04904175,-0.03162266,-0.039196044,0.08269083,-0.05325748,-0.0042353123,0.059976496,0.069869235,-0.0145787075,0.021441048,0.017773299,0.009044414,-0.03906285,-0.07369894,-0.14046736,-0.016596872,0.015490823,-0.049498446,-0.027373014,-0.06652883,0.02953229,-0.0019477304,0.0042598797,0.067010105,0.0072338195,-0.04367359,0.045786053,0.0039679124,0.00084645423,0.11478614,0.060796827,0.10790656,-0.03351609,-0.00085666915,0.11054574,-0.017870698,-0.08427982,-0.043335684,-0.046210665,0.013962591,0.037973545,0.06644019,0.0127201695,0.0620973,0.054048058,0.052756198,-0.010777925,0.07728744,-0.035902448,-0.060105763,-0.0071614375,0.08504104,-0.013658511,-0.009173652,0.06671591,-0.0012879586,-0.01235592,-0.11059686,0.044783145,-0.01859159,0.014219379,-0.024109764,-0.023532309,0.03866783,-0.020639332,-0.017610257,-8.575186e-05,0.015738983,-0.09160171,0.021200506,0.0047111325,0.06632428,0.044451647,-0.02266698,0.03510536,0.016278265,-0.03062799,-4.1721443e-33,0.103359245,-0.10907202,0.026101165,-0.076270565,-0.007507778,0.005844986,-6.385727e-05,-0.0013081966,0.018622989,-0.035597827,0.0777417,0.033570483,0.06301506,0.009526377,0.048785187,-0.026792921,0.016686818,0.05863346,-0.033785492,0.023505097,0.05487705,0.028501632,-0.02866028,0.018758569,0.062499385,0.06030063,-0.02163139,0.012789079,-0.016407814,0.019171879,-0.049518794,0.010373599,-0.10261512,-0.059656605,-0.14247964,0.019880798,-0.029863406,0.030818032,-0.0515932,-0.025518503,0.021722581,0.10452223,0.020749224,0.038047817,0.0170136,0.09581932,-0.008913119,-0.0025803046,0.028944628,-0.045884416,0.019475447,-0.012435632,-0.032504942,0.0008115601,-0.025749428,0.07475741,0.0055726273,0.027639775,-0.021242693,-0.018350821,-0.03300293,-0.083559774,0.049013942,-0.066808544,0.09073309,0.0573874,-0.010863737,0.04957383,0.039160777,0.019376066,0.031850263,0.023631876,-0.018889317,0.08682815,-0.017008469,0.0064131212,-0.03426875,-0.018342378,0.060672354,-0.018180367,0.046808306,-0.0018335768,-0.008536122,-0.06280475,-0.05320574,-0.108694136,0.02274345,0.09317523,0.03586291,0.0368767,-0.08725909,-0.026056461,-0.07139278,0.053331856,0.024674188,-4.406137e-08,0.03600651,-0.041171093,0.009990373,-0.06064416,0.0010266819,0.09734452,0.009043804,0.04429948,0.060896598,-0.054644648,0.026993938,0.07320314,0.0170729,-0.023553893,0.02338543,0.039594036,-0.047874495,0.023172723,-0.023141447,-0.0049859243,-0.020692002,-0.062457073,-0.06308817,0.107654184,0.028760819,-0.09324572,0.078451164,0.081343345,-0.02205615,-0.0770243,-0.045746908,0.0006555466,-0.020125374,-0.006724726,-0.073266,-0.022309631,-0.045805637,-0.02249981,0.00698956,-0.019633463,-0.020452002,-0.030823786,-0.05929248,0.038745064,-0.040171996,0.037936952,0.008537846,-0.055264022,-0.007396223,0.049074367,0.0004815962,-0.009365565,0.05157247,0.024266396,-0.09385536,-0.013188381,0.032290418,-0.0478735,-0.032524522,-0.03595039,0.09133883,0.016411798,0.14534439,-0.049518682 +3.1.3.80,"This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC 5.4.2.11/EC 5.4.2.12 [phosphoglycerate mutases (2,3-diphosphoglycerate-dependent and independent)] and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate [1]. The MIPP1 protein also catalyses the reaction of EC 3.1.3.62 (multiple inositol-polyphosphate phosphatase).",384,0.99999994,-0.05485443,-0.050297815,0.041415896,-0.03556928,0.08146561,-0.048279118,0.03728955,0.09299759,0.043725424,0.057097275,0.019471688,0.023101432,-0.06399753,-0.0025297313,-0.082846925,0.07043897,-0.016978595,-0.027836055,0.0056892773,0.024367373,0.10060769,-0.054064613,-0.025663238,0.025759703,0.03511456,-0.022982039,0.002041318,0.02090443,-0.04938357,-0.06730141,0.009754689,-0.017038338,0.055260923,-0.06272426,0.016139735,0.085283004,0.037068617,-0.07243695,-0.05872597,0.018304797,0.048719622,0.019044489,0.023156507,-0.08184359,-0.0023497029,0.0021927664,-0.031191021,-0.0008355183,0.028172528,-0.0059765186,-0.0436941,-0.086828366,0.013811248,0.030074552,0.037626408,0.004021271,-0.16407813,0.10521499,0.010295033,-0.033917077,-0.054590117,0.009439176,0.07900514,-0.014923272,0.034585856,-0.047736935,-0.00253394,-0.0637848,-0.014822644,0.027130222,-0.062073644,-0.061439488,0.024017392,-0.040497605,0.03816061,0.13481739,0.0016332408,0.026634745,0.05541135,-0.03314512,0.011780537,-0.0017562575,-0.008995637,-0.04493093,-0.0056346864,0.075097606,-0.013418085,0.011628383,0.0033548488,-0.036094747,0.02076537,-0.033648524,0.029282872,0.018420605,0.013905119,0.077281676,-0.022993818,0.029816613,-0.005740211,-0.021438485,-0.008305967,0.1193077,-0.038063787,-0.082107954,-0.049563766,0.0156104695,0.010162474,0.048635133,-0.020370508,-0.08325193,0.0048062894,-0.038551718,0.05443967,0.02232981,-0.060051635,0.09381595,-0.017923774,-0.015295551,-0.06550079,-0.02720211,0.057643183,-0.07838425,-0.053300694,0.047916144,-0.09976563,0.056807138,-0.049250618,3.7539067e-33,0.09000742,0.009057444,0.024446903,-0.0015807479,-0.02580872,-0.030104982,-0.015887024,-0.029832043,-0.10191948,-0.027355412,0.0014734648,-0.060422413,0.074443474,0.025468212,-0.043934193,-0.037991356,0.006309213,0.013521106,0.057645697,-0.05853811,0.010444872,0.015014838,-0.04894664,-0.040077105,0.057278715,0.1140324,-0.046919942,-0.07351544,0.05051717,0.018394273,-0.041659415,-0.01884262,-0.107032984,0.06466833,-0.06648543,-0.045610458,-0.05250516,-0.09515225,0.01295096,0.047384508,-0.0072514582,-0.008764673,-0.020448366,-0.0038385608,0.047344983,-0.03438281,-0.05974147,0.014567555,0.1315108,0.071182325,0.003332494,-0.024521034,0.080655046,0.014448129,-0.017252356,-0.039435733,-0.07123248,-0.06212086,0.059479352,0.051468216,-0.016801443,0.057027485,-0.016949343,-0.020587401,-0.022747016,0.02598107,-0.11682183,-0.026605941,-0.041570373,0.09685161,0.014222965,-0.05300992,0.035242826,0.050796848,-0.015788639,-0.086288184,0.05381581,0.0383587,-0.06469161,0.07394082,0.035209335,0.0017677272,-0.040139273,0.025981668,-0.04027318,0.056524333,0.030036578,-0.083448805,-0.0010202979,0.07480344,0.027110212,-0.0016018739,-0.03560865,0.026494732,-0.09174295,-3.9339843e-33,0.08405803,-0.039872874,0.020246875,-0.057625953,-0.113588616,0.025967645,0.020454772,-0.027482236,0.09211017,-0.009246372,0.0029620768,-0.04825136,0.039323952,-0.09739715,-0.024449619,0.012773784,0.044775706,0.0053372495,0.0080355685,0.0037062007,0.07403944,0.03963714,0.05344205,0.08479876,-0.011654652,0.0064854603,0.05073289,0.010753591,0.0024108274,0.027064955,-0.04983211,0.02884539,-0.055649042,-0.062466215,0.0034777857,-0.009901915,-0.08450213,-0.020755637,0.03057445,0.007998418,-0.0049117454,0.026947536,0.112102136,0.035065364,0.06699481,0.07749934,-0.0059321895,0.06112626,-0.013555369,-0.028539527,-0.00050497503,0.038270973,-0.00875894,0.073360965,0.04265434,0.0598318,0.015839005,0.0421095,-0.069961265,-0.014147025,0.0060708,-0.029884003,0.0047277836,-0.021771627,0.13819233,0.16725771,0.04935462,-0.008559324,-0.017617354,0.020864358,0.08319041,-0.08915419,0.012995553,-0.016580142,0.05313409,0.009292213,-0.13351254,0.040816516,0.028939012,-0.024159757,0.009311672,0.04393388,0.020724742,-0.09264909,0.07085216,-0.05332721,-0.023750607,0.119279906,0.012760638,-0.0050879414,-0.026009487,-0.035280276,0.02462026,0.034695085,0.087147705,-4.6770705e-08,0.061751477,-0.08635303,-0.027665282,-0.036026847,-0.041757844,0.011215506,0.027665919,0.026779106,-0.01952885,-0.00015510856,0.008037903,0.0080511,0.062455337,-0.033950154,0.073594995,0.07256252,-0.107001744,0.00352039,-0.015825406,0.00763476,-0.041040104,-0.035749897,-0.062215235,0.06341288,-0.024211276,0.02473684,0.09626758,0.03776404,-0.05502863,-0.01861874,0.01454182,-0.0008026372,0.000464858,0.021187812,-0.047629405,0.025780782,-0.065212056,0.012114841,-0.06099678,-0.01402205,-0.074307345,-0.0052482025,0.047878154,0.008238907,-0.04738629,0.0103759,-0.018953169,0.0011079523,-0.02364471,-0.0035394775,0.004530713,-0.026994534,0.0010843788,-0.078419045,-0.13169011,-0.073579185,0.041124806,-0.02407721,0.030779717,-0.06512308,0.020275123,0.009385675,0.08979664,0.012418591 +3.5.1.102,"The enzyme catalyses the second step in archaeal riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis. The first step is catalysed by EC 3.5.4.29 (GTP cyclohydrolase IIa). The bacterial enzyme, EC 3.5.4.25 (GTP cyclohydrolase II) catalyses both reactions. ",384,1.0,-0.083652265,-0.03328545,-0.07443983,0.015112863,0.058111522,0.018298829,-0.11610227,0.019925889,0.04085655,-0.033975277,-0.03796591,-0.04757584,-0.029906029,0.012216747,-0.01766888,0.009677649,-0.09696909,0.02779949,-0.01764901,-0.086802416,0.028297802,0.026676727,-0.0028907703,0.03377291,0.047699627,0.009262657,0.041758385,-0.00020578285,-0.021880513,-0.043181233,-0.029316302,-0.084830694,0.06474885,-0.064804286,0.026524544,0.09502371,-0.031806603,-0.07905692,0.030707894,-0.0149821555,0.013834656,0.00814101,-0.0059522353,-0.0001897963,-0.0384778,-0.012562638,-0.014397608,0.07734197,0.062103458,-0.048651617,-0.045237172,0.010450923,-0.026804194,-0.039543316,0.06473913,0.013921933,-0.005368907,-0.07734085,0.028473476,-0.01888398,0.035494346,-0.016258193,-0.038486138,0.0048873657,-0.031935133,-0.06658422,0.0747276,-0.09437644,1.7972785e-05,0.030715728,-0.0549652,-0.09297499,-0.031811394,0.04973999,-0.021563305,0.03192636,0.017265314,-0.035308134,-0.0012315414,-0.066586226,0.057234466,-0.0044781617,0.015325179,0.06715836,-0.021681415,-0.034802265,-0.007905104,0.0018996849,0.041839093,0.05407452,0.07073365,0.01796638,0.060149886,-0.07377921,-0.037681676,0.028435156,0.042507816,0.05157168,0.052892663,0.0049225013,-0.00852122,0.030554399,-0.03403563,-0.07572372,-0.028799925,-0.011698518,-0.024065556,0.124736525,-0.005719799,0.02648171,0.024684906,-0.07612006,0.03610239,0.020792264,-0.03510097,0.12709203,0.057660308,-0.061198488,-0.11635379,0.023038454,0.024330858,-0.03003415,0.1110693,0.10053236,-0.1014028,-0.0035057175,-0.08755103,3.6586046e-33,0.053643044,-0.00855264,-0.023126088,-0.029780997,0.0032557354,0.013218821,-0.12216041,0.059174202,-0.0028504077,0.018434975,-0.064795904,-0.04582981,0.06399801,-0.05043143,-0.078608125,-0.070043094,0.0011405844,0.017952623,-0.031602323,0.04926431,0.010201053,0.059632096,0.008776188,0.060786754,0.056895304,0.07399946,0.026773883,-0.05263469,0.077111624,-0.029897833,-0.012420946,-0.16324341,-0.12932312,0.0048678406,0.047852837,-0.030704638,-0.00831256,-0.022045782,0.030338883,0.06553407,0.026169077,-0.015547422,-0.005075486,-0.059302837,0.055562947,0.03931271,-0.04263928,0.06685428,0.025722917,0.06362681,0.072597556,0.005063594,0.052049186,-0.009153526,-0.043519307,0.035590626,-0.00066997943,0.019935653,0.09021596,0.040497165,-0.012393103,0.048837624,-0.0018687713,-0.04054391,-0.0402239,0.0031060558,-0.013363089,-0.03621117,-0.006276001,0.01486334,-0.01918025,-0.020467626,0.09059276,0.08372213,0.043385554,-0.020795166,-0.0845546,-0.0367867,0.02653354,0.0073332214,-0.086721815,0.047043115,0.029621592,0.026869304,0.011483193,0.018586129,-0.05577557,-0.0533324,-0.06802107,0.03592896,-0.010736672,-0.05205357,0.0002276452,0.047160424,0.06243783,-4.8321858e-33,0.11596814,-0.12984717,0.048738044,-0.10945367,-0.042615034,0.06239695,-0.066334665,-0.05122116,0.014556221,0.0017604857,0.09496243,0.029460754,0.062051967,0.014337912,0.019962002,-0.0352454,0.045524705,0.089892134,-0.090192825,0.0049110316,0.059765868,-0.050161533,0.0003399004,0.067816876,0.039427694,0.04851434,0.09415454,0.035314973,0.034599844,0.09945105,-0.021534864,0.017366713,-0.06368293,0.011080898,-0.024748543,0.1127952,-0.030564582,0.0046952204,-0.044976868,0.00725412,-0.059677217,0.070446454,-0.0115277255,-0.0027203115,0.005155601,0.06948256,0.022478562,0.032157302,-0.006179563,-0.04731185,0.09381343,0.017496161,-0.012146754,0.023388017,-0.051162157,0.029554324,0.073458195,0.011631073,0.063606456,0.021494243,-0.030134568,-0.061974216,0.04627866,-0.012861791,-0.0032081483,0.058029648,-0.035871435,0.046011206,0.0009476827,-0.062147476,-0.0017405319,-0.015968144,0.025660077,0.07517877,0.038243677,0.013342794,0.03398995,-0.07839846,0.026532795,-0.08444195,-0.022839196,-0.009831643,0.013552409,-0.03353062,-0.06260051,-0.11437372,0.06910338,0.07222765,-0.031265132,0.042611375,-0.022246901,0.008558285,-0.015717288,0.06087064,0.09182362,-3.7260527e-08,0.010149684,-0.02085926,0.07321699,-0.042880736,0.042863723,0.03340727,-0.043282297,-0.009779499,0.04383492,-0.091664426,0.006545324,0.0369977,-3.4371915e-05,0.013477969,0.016649513,0.027881844,-0.0573212,-0.018391112,0.0038505143,-0.007747346,0.017330546,-0.000719344,-0.10249688,-0.025933197,-0.031888504,-0.08920741,-0.03319296,0.014757236,0.021371378,-0.021606743,0.009667071,0.073997036,-0.048950806,0.00022052672,-0.0009841084,-0.03484751,-0.02627345,-0.04875374,-0.03384626,-0.025997903,-0.060344823,-0.039927498,-0.08717628,-0.010611633,-0.05521966,0.015332296,-0.038331933,0.025583167,-0.0096707875,0.045164496,0.071525164,-0.015268086,0.066029556,-0.052884057,-0.06943375,-0.031172495,-0.022662297,-0.10244949,-0.06324441,0.016406853,-0.024132464,-0.031036323,0.17941973,-0.03092801 +3.5.1.103,"This enzyme is considered the key enzyme and rate limiting step in the mycothiol biosynthesis pathway [1]. In addition to acetylase activity, the enzyme possesses weak activity of EC 3.5.1.115, mycothiol S-conjugate amidase, and shares sequence similarity with that enzyme [2]. The enzyme requires a divalent transition metal ion for activity, believed to be Zn2+ [3].",384,1.0,-0.0025880265,-0.040382143,-0.10029765,-0.0091963755,0.14665315,-0.07884217,-0.061067536,0.06157004,-0.0018712279,-0.040258374,0.034057103,-0.05765742,0.007968834,0.03096942,-0.09478485,0.022705806,-0.036237206,-0.007005465,-0.011871175,-0.055067796,0.052044623,0.103097804,0.0032359601,-0.00147649,0.007151694,-0.057620417,0.037934087,0.01744821,-0.052547295,-0.08560452,-0.07084982,-0.049163174,0.062630236,-0.02522775,0.053360023,0.09524288,-0.08349377,-0.018486936,0.056465607,-0.013375017,0.067506336,-0.013987201,0.044073265,-0.055657424,0.045192786,-0.034784775,-0.052749474,-0.035537835,0.0073568304,0.02987816,-0.09942925,-0.015116231,0.05951671,0.013405282,0.022399314,0.056497123,-0.05425565,-0.018747276,-0.062844805,0.07342459,0.039177097,-0.05451243,-0.055681486,-0.07710599,0.008142983,-0.023620956,0.007299842,-0.08077163,0.016744265,0.0006980306,-0.06749911,-0.035929196,-0.052071773,0.028958388,-0.0049537066,-0.018366557,0.003835362,-0.04971346,0.06162588,-0.047989234,0.004454945,-0.042455707,0.02928271,-0.04978324,0.025454264,-0.023382694,0.058927603,-0.014716137,0.02022596,0.10820434,0.087424785,-0.038219467,-0.013218733,-0.0114856595,-0.027045237,0.050836246,0.10152326,0.025450828,-0.030500818,-0.014714518,0.07744988,0.02745948,-0.03453517,-0.09256825,-0.048075378,0.02378946,0.07428051,0.07839272,0.009991935,0.06511616,0.020865621,-0.068188965,0.020669032,-0.03570075,0.012273912,0.122200854,0.013070414,-0.02600364,-0.044639282,0.020308958,0.03230902,0.010826788,-0.012858797,-0.022538569,-0.07751989,0.0103657795,-0.030340198,1.9389583e-33,-0.008501104,0.060065124,-0.093095645,-0.02529646,0.008671412,-0.05489948,-0.097409695,0.026135752,-0.060453385,-0.092292525,-0.05113412,-0.065320276,-0.056583732,-0.03786697,-0.08181293,-0.022139706,0.020436132,-0.029683461,0.056245238,0.07697676,0.004812733,0.0077176075,-0.096660234,0.023923658,0.056394383,0.0042831386,-0.023766687,-0.030602096,0.009450658,0.0071482845,0.059440307,-0.0076664467,-0.13161801,0.026761819,0.10977461,-0.02311877,0.041975226,-0.049156636,0.0075548943,-0.011540559,-0.0275594,0.0682329,0.030553278,-0.014977728,0.008379707,-0.02517209,-0.025186302,0.08713419,-0.0023885455,0.016914492,0.07275335,-0.014722034,0.0890919,0.006240936,-0.046121318,-0.016332785,-0.03063302,0.0125104245,0.05716422,0.061133705,-0.027084012,-0.006449007,-0.02529823,0.09967069,-0.05281615,0.031468377,-0.12551612,-0.020836547,0.057645284,0.08107966,-0.011866521,-0.010013539,-0.0045909677,-0.015061531,0.07129051,-0.056002397,-0.068499774,0.022720005,0.0030176959,0.011939232,0.007993056,0.039645206,-0.010664936,-0.015948642,0.007469743,-0.005656377,-0.046839174,0.024891393,0.0010806487,-0.01703843,0.008303057,-0.013386556,0.026267987,0.09876476,0.045620147,-2.5955035e-33,0.092018425,-0.06742829,0.12252555,-0.038673792,-0.054665226,0.07978153,0.00083426194,0.0005639796,0.04949137,-0.0021804057,0.08195804,0.005205421,0.06836531,-0.049751386,-0.016761782,0.009742582,-0.033042446,0.13115098,0.06998486,-0.012256978,-0.029796204,0.096893825,-0.023431994,0.02331444,0.035638537,0.0009907158,-0.012770222,0.06908638,0.07845989,0.053528592,-0.027869789,-0.023210993,-0.019658722,-0.061755694,-0.057362568,0.04814458,-0.025108028,-0.016513618,-0.03471018,0.023058914,-0.0062423768,0.050895095,0.010311196,0.046694845,0.0056270747,0.024776665,-0.066938475,0.059948318,-0.053202342,-0.093233965,0.02950612,-0.016197607,0.008967439,-0.01933104,0.05276453,0.06362625,0.04962709,0.0057998584,0.008512655,-0.029352177,-0.040184528,0.014085573,-0.012976248,0.011609744,0.06727141,0.024967646,-0.015129657,0.07897662,0.044208825,-0.028887993,0.04888249,0.04368909,0.055462353,0.102494895,-0.0066485913,-0.041821565,-2.2610653e-05,0.023777181,0.04067983,-0.028935468,0.06346676,0.030198412,0.041301895,-0.12479323,-0.062627904,-0.09906253,0.082181424,0.12775898,-0.06388001,0.045067858,-0.012731125,0.032857012,-0.08101127,0.01745924,-0.008905585,-3.7471192e-08,0.041688915,-0.061497387,0.055911858,-0.0665801,0.03580959,0.01679901,0.045246042,-0.013319971,0.07230078,0.0025927173,-0.011530987,0.0701011,0.051703226,-0.0052352776,0.023543788,0.0011256377,0.033302262,0.016137648,-0.011679017,0.060676273,-0.04458599,-0.026768433,-0.08687258,-0.023296,0.015005784,-0.05508699,-0.011812927,0.073112875,-0.0476073,-0.030675033,-0.043667845,0.007321628,0.028834807,-0.016474308,-0.1285445,0.030471716,-0.1083464,-0.1386953,-0.0032818567,-0.02070405,0.025731368,-0.08573927,0.031585276,-0.016570421,-0.07623122,-0.060766052,0.013613824,-0.04073993,0.038528953,0.019114517,-0.010667984,-0.058238104,0.045630723,-0.06374677,0.04031141,0.0049881204,0.043387286,-0.008279062,-0.009303165,-0.055936445,0.07202698,0.011058145,0.0780844,-0.034912806 +4.1.2.44,"The enzyme is involved in the aerobic benzoyl-CoA catabolic pathway of the bacterium Azoarcus evansii. The enzyme converts 2,3-epoxy-2,3-dihydrobenzoyl-CoA to its oxepin form prior to the ring-opening and the formation of a dialdehyde intermediate.",384,0.99999994,-0.08301091,0.009130865,-0.0889375,-0.028270153,0.10526969,-0.02858348,-0.07265021,-0.0011600197,0.074201554,-0.035433758,0.003693458,-0.086210735,-0.028333185,0.0061832047,-0.079041764,0.010243882,-0.12389422,-0.008866248,-0.026965844,-0.018544298,-0.015357354,0.07630426,0.006317311,0.042175222,0.02725109,-0.030787775,0.034378808,0.049623944,-0.01121122,-0.042722806,0.061298735,-0.015144471,0.045476146,-0.059306018,0.002191993,0.07225335,0.021820579,-0.083684824,0.0035647277,0.04701428,0.0077068103,0.0037481724,-0.026081994,-0.001132585,-0.09787191,-0.0031908855,0.045842554,-0.0065977788,0.04872976,-0.0062136543,-0.018561875,-0.019062197,-0.08226677,0.038629487,-0.008508271,0.016083326,0.005431082,-0.026832493,-0.08295034,0.017308522,0.029197792,-0.017885216,-0.039225735,0.07138411,-0.0672515,-0.015832514,-0.0013351641,-0.039479006,-0.03580632,-0.11435444,-0.09944983,-0.07140667,-0.025160534,-0.0093398765,-0.015996093,0.031353373,-0.02806844,-0.0180699,0.075060494,-0.035602435,-0.015882635,-0.0071327533,0.013352485,0.08220755,0.0037577655,0.0029782134,0.007363678,-0.019932121,0.049795877,0.0327673,0.044474807,0.0243708,-0.032108653,-0.0009768653,-0.08954564,0.077258095,0.097386956,-0.02218156,0.026855092,0.04201421,-0.019514227,0.083285615,0.019482601,-0.14332534,-0.09692582,-0.00049601,-0.036780912,0.13079536,0.020262005,-0.02532695,0.0061841668,-0.033583798,0.091451325,0.004416205,0.04520063,0.058649942,0.031020798,-0.056587826,-0.05129067,0.057463724,-0.048650008,-0.04054589,0.004422099,0.010464575,-0.044479176,0.019927582,-0.07171,3.5237629e-34,0.08230457,0.03310323,-0.023122545,0.016706219,0.02914837,0.0023566515,-0.13792437,0.014771139,-0.02567583,-0.017131897,-0.067494385,-0.091107056,0.04799539,-0.009393508,0.021339864,-0.019997148,-0.04704267,-0.015587274,0.0114177475,0.040080797,0.033834197,0.0055063856,-0.055656992,0.019410823,0.07320316,0.081326,-0.0077215536,0.023671962,0.02318445,0.020347327,0.01848667,-0.105003245,-0.15316853,-0.033795983,0.010298551,0.0013124443,-0.03475115,-0.0010590302,-0.023754658,0.013980818,0.06899089,0.0019496256,0.008207145,-0.019447517,0.07663275,-0.026491249,-0.019171724,0.17199834,0.035225067,0.020905068,0.060721885,-0.030248638,0.12738356,0.008175636,-0.09269678,0.094555706,-0.007583359,-0.00091853976,0.04162419,-0.024361499,0.03285532,0.0718268,-0.027809547,0.07273963,0.020174583,0.0047683953,-0.051756486,-0.029574184,-0.034213044,0.0681252,-0.049216583,0.001465781,0.017264457,0.023599068,0.022880087,-0.04024106,-0.07791004,-0.018496867,0.10346551,0.025110407,-0.02803656,0.011401839,0.034430295,-0.068610914,-0.02179545,-0.010367733,0.019507444,0.020996435,-0.01555183,0.066289835,0.12378975,-0.067248195,-0.0133151505,-0.031045334,0.048557993,-9.306759e-34,0.122228906,-0.13527,0.07377719,-0.14665976,0.011723514,0.048157923,-0.00055488164,0.022293143,0.010507712,-0.02620637,0.09132024,0.021116242,0.00048551234,-0.0044576675,0.0759808,-0.03330432,0.063468225,0.012933484,0.025367668,-0.003731223,0.04638298,-0.025587684,0.017568814,-0.050350204,-0.0038291032,-0.014871414,-0.012516297,0.051636007,0.032989975,0.040402666,-0.03318589,-0.003452768,-0.021937195,-0.0014149115,-0.027213473,0.07742962,-0.02746405,-0.008922602,-0.009894819,-0.0054044793,-0.026669817,-0.04194861,-0.03531633,0.06377795,0.019543441,0.05949745,-0.11678308,-0.03983591,-0.04011736,-0.06518165,0.0033248586,0.053391755,-0.029185172,0.066773444,0.036315553,0.07841176,-0.0073222537,-0.05421103,0.014905148,-0.05690381,-0.05784796,-0.024081882,-0.0042371307,0.008172787,0.022345105,0.033605702,-0.04357045,0.04682671,0.02016416,-0.03897259,0.06504629,-0.022761483,0.051256154,0.039471526,-0.036502175,0.012870259,0.007954271,-0.026208317,-0.011648694,-0.010749659,-0.03299984,-0.01337518,-0.0055223415,-0.021660915,-0.08686293,-0.11497841,0.024382988,0.08242459,-0.0009107976,0.0020285102,0.004730125,0.03816291,0.027847461,0.07789062,0.097093426,-3.4903486e-08,-0.07359402,-0.06531452,0.08451932,-0.043215945,-0.00011305335,0.0538203,0.04679165,0.021417797,0.03194245,-0.0445241,0.05253018,0.078711025,0.058541927,0.055011556,0.024006756,0.01813245,-0.0008878077,0.01013276,-0.013183475,-0.021131,-0.04376519,-0.006878121,-0.036539786,0.040307023,0.037583854,-0.057172548,-0.025259797,-0.0005642099,-0.021956068,-0.024921093,-0.028271098,0.063487746,0.012814064,-0.026416358,-0.13363205,0.042886306,0.0069781546,-0.036343135,-0.05887877,-0.0053385473,0.07755713,-0.0476393,-0.12362493,-0.04357548,0.07044522,0.0073680906,0.036234856,0.07526327,0.001176945,-0.02858745,0.054704238,0.023990432,0.028481325,-0.021380754,-0.088232085,-0.01380983,-0.00090005324,-0.04022501,0.008088833,0.0064242426,-0.027692163,0.048887305,0.14951849,-0.041370016 +4.3.1.26,"This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. The enzyme also possesses catalase activity.",384,0.99999994,-0.034310497,-0.015845044,-0.13162512,-0.02338985,0.0030866354,0.057066783,-0.0329319,0.055571117,0.082187,0.021243623,-0.039632175,-0.041310713,0.031316508,-0.024192894,-0.0604481,0.090378046,-0.058908317,0.04676287,-0.045717455,-0.009123365,0.03156626,0.01512195,0.027544843,0.026057467,0.07681934,0.05171868,0.047099195,0.06604912,-0.1083904,-0.06414514,0.031204162,-0.062075708,0.026188342,-0.025943264,0.083399236,0.026470566,-0.02222304,-0.023454646,0.10751168,0.008422849,-0.036160816,-0.024213605,-0.036508363,0.0120133525,-0.098194145,-0.0147491265,0.024691546,0.032907333,0.059491355,-0.04477639,-0.057768304,-0.06721293,-0.05265754,0.013731461,0.05047133,-0.032019593,-0.020451173,-0.029425403,0.018000452,-0.0013762375,0.06418947,-0.013138528,-0.009935419,0.015510267,-0.05249042,-0.11879282,-0.013479595,-0.06016794,0.040842943,-0.04174881,-0.07028489,-0.06104706,0.00079727866,0.06580071,-0.00581718,0.004568649,0.008063291,-0.04012955,-0.0196076,-0.027585557,0.027006218,0.026508573,0.06374734,0.15658617,-0.0052867946,0.08755798,0.0492533,0.005602431,0.05235284,-0.008726264,-0.0033359027,0.015945977,-0.0071551856,-0.066406995,-0.06691,-0.016759584,-0.022266885,0.07578445,0.0020423138,0.006176494,0.032040052,0.011316587,-0.035658445,-0.08191894,-0.04719627,-0.017355308,0.0051966985,0.10558889,0.0622319,-0.07417353,0.019566553,-0.044243373,-0.007016437,0.0012443889,-0.048298392,0.105287686,0.10328647,-0.070592366,-0.11587758,0.014700568,0.047723826,0.018062197,0.063126326,-0.013147869,-0.04923572,0.027302222,-0.08193874,4.885471e-33,0.047039438,0.10454088,-0.0118317865,0.007088462,-0.010403926,-0.029573418,-0.13444832,0.017053979,-0.017145962,-0.013946842,-0.1171401,-0.056074332,0.008699221,-0.052888237,-0.02435732,0.00419731,-0.07718987,-0.011326699,0.018298145,0.05041536,0.02418957,0.019658636,-0.019596312,-0.004412861,-0.0027396295,0.032063633,0.024412131,-0.0033722736,0.0866286,-0.002217391,-0.008871365,-0.036245447,-0.09762044,-0.03347874,0.023280784,-0.026446922,-0.051077355,0.017667966,0.0062737004,0.08619271,-0.010331627,0.026698565,0.015911348,-0.0059144213,0.049944755,-0.05007509,-0.026290908,0.12186053,0.10367118,0.058995552,0.008071192,-0.025387185,0.16110732,0.033600174,-0.086835004,0.024460359,-0.0100448,0.0067247665,0.06809074,0.050240234,0.00051284686,0.019435402,0.0072014085,-0.018514011,0.0730811,-0.043514553,-0.0058839195,-0.061156124,0.028297933,0.08117081,-0.04948632,0.014912328,0.106127985,0.03407604,0.031106446,-0.05382874,0.0016936255,7.95191e-05,0.06604664,0.019534871,0.05885419,-0.06112781,0.011624718,-0.08545317,-0.03480183,-0.02839415,-0.067939475,-0.048402067,-0.091447674,0.06553491,0.0025323618,-0.08093826,-0.102131054,-0.028988069,0.012967556,-5.5270433e-33,0.10730982,-0.08689592,0.023538029,-0.056430466,0.005543348,0.038420055,-0.018745892,-0.008147465,-0.02527343,0.026445534,0.10906511,-0.038213372,0.040905148,0.0056632166,0.035071682,-0.06316326,-0.028321931,0.08655976,0.001805374,-0.01939529,-0.031612314,0.086876415,-0.057372265,0.0019897013,0.07641545,0.046882935,-0.010267352,0.0411657,0.04868461,0.051267568,0.04858783,-0.009941014,-0.087137766,-0.063538395,-0.010026394,0.07573499,-0.0636896,0.029856209,0.0674081,0.016576892,-0.022584092,-0.0034859476,0.014523392,0.032227106,0.063596055,0.018758075,-0.087320365,0.0844016,0.012154959,-0.059383143,0.020222845,0.011126322,-0.071418144,-0.021501567,0.049015786,0.034143426,0.040812463,-0.013961776,-0.014885883,-0.005984984,-0.08226299,-0.033631954,0.0735827,0.00012410957,-0.02929919,0.10901115,-0.015050427,0.04295237,0.07621638,0.013080144,0.030187039,-0.0032541049,-0.0036956356,-0.01339131,-0.018418415,-0.0022625064,-0.013760132,-0.024176199,-0.0043972433,0.016744994,-0.02063225,0.0011278476,0.04757361,-0.04753582,0.020118175,-0.050187107,0.014204105,0.06996124,-0.015673593,-0.021835318,0.051064603,-0.0077845114,0.019910889,0.06874639,0.0061320593,-4.259553e-08,0.060864404,-0.066518135,0.030059228,-0.045708247,0.0037890186,0.02132832,-0.017809113,-0.04858541,0.05258771,-0.037057284,-0.0014517917,0.084874704,-0.024191229,-0.0042003985,0.009803149,0.013359925,-0.024013547,0.061829027,-0.008860636,0.005046543,-0.031993434,-0.039840773,-0.08077748,0.023078134,0.027261129,-0.060925595,-0.013571477,0.004642486,0.024435636,-0.026077323,0.05346661,0.05226518,-0.054724563,-0.039533004,-0.06158166,-0.03562029,-0.077851295,0.019464312,-0.03678252,-0.065079235,0.07180755,-0.066566564,-0.10258343,0.030020826,-0.04954683,-4.873515e-05,-0.017447129,-0.017905636,-0.053120892,-0.03621774,0.029819058,0.030694105,0.022848845,-0.03127936,-0.15027474,0.0539653,0.018342467,-0.06176833,-0.019612936,-0.09867214,-0.036949687,-0.026419245,0.145787,-0.015516348 +4.3.3.5,"This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a glycosylase, and acts in the reverse direction to that shown. It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole [1,2].",384,1.0,-0.02011107,0.001144746,-0.14420865,-0.023331111,-0.04510027,0.057893407,-0.041760713,0.03636087,0.082537964,-0.0023419706,-0.024833476,-0.0299963,0.03584411,0.0001281957,-0.08923777,0.035087347,0.022641784,0.03231315,-0.019385194,-0.02020649,0.03347857,0.007819734,0.039417762,0.021407466,0.11502709,-0.0013852165,0.004115338,0.04355595,-0.08034842,-0.07003143,0.041644365,-0.063587576,0.06338897,-0.03679117,0.07425547,0.036296617,-0.028469622,-0.009433799,0.13187999,0.01578211,-0.04796014,-0.024725415,-0.0058028945,0.0014266653,-0.087169535,0.010300978,-0.010180089,0.041483253,0.07930825,-0.017947875,-0.0396536,-0.04109489,-0.03382487,-0.0011758064,0.059626285,-0.021112995,-0.05019133,0.009579956,-0.015916646,0.006540667,0.09590852,-0.0023213036,-0.012184188,0.048801776,-0.100123465,-0.10380469,-0.0055193254,-0.02978155,0.047933254,0.024251578,-0.09172999,-0.06747426,0.009471158,0.010375842,0.036250606,0.03587349,-0.017618729,-0.02191673,-0.019564886,-0.052866016,0.10404495,0.014399026,0.0755382,0.069737904,-0.057192124,0.054693434,0.09232123,0.0147919115,0.09086485,0.012391303,0.018476298,-0.006237672,0.025984528,-0.067239076,-0.061617844,-0.035291318,0.0065234913,0.048811194,0.007653261,-0.002211236,0.04129243,0.008128937,0.050255466,-0.034014672,-0.076721154,0.022574823,-0.033670954,0.06828931,0.057984572,-0.06953099,-0.027942598,0.009178523,-0.019924711,-0.036428444,-0.07081479,0.08069969,0.05518756,-0.059909232,-0.112531595,-0.016322954,0.0155135635,-0.008280504,0.042356502,-0.014172779,-0.008818002,0.04509843,-0.06080547,1.2378616e-33,0.043894082,0.104225256,-0.048197355,-0.054733228,0.031103162,-0.054809347,-0.08366454,-0.0012483464,-0.024687346,-0.034212273,-0.11688923,-0.017073395,-0.0201256,0.031994626,-0.008763466,0.04781964,-0.05621402,-0.0068025617,0.039156467,0.024308424,0.055612363,-0.0006812941,-0.07273215,-0.04112913,0.006500206,0.05089976,0.048469648,0.04816106,0.027757743,-0.013311767,0.005770407,-0.038344443,-0.085160896,-0.00984515,0.0657288,-0.005306469,-0.058675844,-0.022888474,0.074549705,0.06939258,-0.017051624,0.033778016,0.03592109,0.026881132,0.025557894,0.0027069673,-0.026089828,0.120982,0.08624359,0.039349284,0.021854656,-0.060131524,0.11360492,0.07096527,-0.06766685,0.08767112,-0.007272718,-0.01713964,0.020917213,-0.0048852786,-0.023206662,0.018791802,0.01920276,-0.0313887,0.051367328,-0.014365425,-0.060299855,-0.020860558,0.025200265,0.061529957,-0.03408644,-0.0113143055,0.084105544,0.08216407,0.007332292,-0.036815763,0.037290115,-0.043157592,0.019527303,0.021078352,0.00414147,-0.028676083,-0.022662815,-0.07854279,-0.023074437,-0.024850227,-0.10390562,-0.0780239,-0.05445801,0.12385299,-0.023678927,-0.062823884,-0.06768662,0.020998754,-0.020919004,-3.8834557e-33,0.14773649,-0.09850972,0.025032546,-0.04839077,0.014659284,0.051247176,-0.00878251,0.023015168,-0.030644054,0.035675533,0.02965589,-0.005820326,0.069731824,0.017100228,0.003891186,-0.073593356,0.01530266,0.081225246,-0.0435149,-0.008194855,-0.041791763,0.07658307,-0.05137302,-0.024316793,0.023906799,0.005131058,0.055991217,0.059148684,-0.020960083,0.06334396,0.04001346,-0.0034233462,-0.058714822,-0.05230297,-0.020041231,0.08327054,-0.038012385,-0.020601975,0.0066358945,-0.043529015,0.009150298,0.041729793,-0.009711598,0.025352936,0.114057675,0.060542803,-0.05394166,0.04542725,0.016378619,-0.06931522,0.008689131,0.022684086,-0.017427241,0.0047914484,0.035523504,0.039372798,0.08927093,-0.05839446,-0.0017530594,-0.015170425,-0.07537683,-0.046973255,0.04205336,-0.017952811,0.03402175,0.09550178,-8.2099185e-05,0.034793526,0.09303037,-0.00074402074,0.04212128,-0.066885844,-0.024455274,0.04500099,-0.04423648,0.04057911,-0.068877704,-0.047922783,0.00044479093,-0.002971409,0.015761266,0.0033758162,0.067404106,-0.05736953,0.0016208596,-0.034266956,0.023833519,0.07391363,-0.013977065,0.031856682,0.060848147,0.023860099,-0.022426168,0.03380173,0.03201661,-4.4448274e-08,0.089777865,-0.051590573,0.045635745,-0.093556836,-0.019555606,0.054647043,-0.02922612,-0.03894795,0.021855384,-0.07762302,-0.032998122,0.060303777,-0.028643038,0.0023621244,-0.004895045,0.013301585,-0.05966698,0.04718405,-0.03345333,0.012493143,-0.10965997,-0.024984024,-0.090965256,0.034812093,0.0057917894,-0.035444297,0.019050516,0.05060978,0.029442698,-0.021097474,0.006738113,0.070217095,-0.08893074,-0.023264775,-0.09153572,-0.059868675,-0.056894097,-0.00848904,-0.039661996,-0.07382963,0.07233513,-0.036474288,-0.07085608,0.02845597,-0.051267583,0.007975392,-0.00046257523,-0.045788087,-0.071601816,-0.029632473,0.022762695,0.0163691,-0.016677758,-0.060221117,-0.15285519,-0.007382823,-0.06320468,-0.043392185,-0.061182532,-0.0726472,-0.07229391,-0.029458748,0.12939613,-0.013463097 +1.1.1.302,"The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC 1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate [1].",384,1.0,-0.023266928,0.0068978597,-0.09897158,-0.006776414,0.019185236,0.07276283,-0.07523209,0.052266557,0.061293498,0.02574339,-0.031605314,0.050157443,-0.052728556,0.0152925,-0.058377683,-0.04067067,-0.08437667,0.03450103,-0.047454588,-0.07237463,0.015214775,-0.0034705112,-0.005816146,-0.021163957,0.067981735,-0.05646505,0.006210123,-0.023635907,-0.035775017,-0.05404461,-0.023209985,-0.06216974,-0.033587128,-0.09521717,-0.016569754,0.114245914,-0.046127878,-0.078925505,-0.025355743,0.028381037,-0.008683104,-0.007666101,-0.06265878,0.012523708,0.0032433327,-0.0031540408,-0.07391486,0.11501601,0.0524838,0.0002719806,-0.063007094,0.023997001,-0.063738704,-0.048993323,0.09026893,0.007843239,-0.013246147,-0.03206867,0.036781006,-0.050504494,0.019296905,-0.08958656,-0.031087395,-0.014770517,-0.001671524,-0.022621632,0.06395878,-0.10344218,0.0050381613,-0.05265567,-0.03824683,-0.0547908,0.01470582,0.0153612,-0.029495463,0.0097591765,-0.03058376,0.02025874,0.011435876,-0.009712301,0.04446883,-0.0338052,-0.036502678,0.0020619228,-0.0058402335,0.042231582,-0.050553154,-0.020490969,0.05150447,0.041121088,0.03719062,-0.024548871,0.044088423,-0.061966605,-0.10690494,0.018706685,-0.018501211,0.04204715,-0.0027685382,-0.014172968,0.019338902,0.08870841,-0.047251787,-0.1173907,-0.015513571,0.0324953,-0.033689965,0.124324314,-0.07381735,0.005628218,0.016245883,-0.00708671,-0.008931284,0.023796456,-0.0756781,0.10331548,0.032102358,-0.046528444,-0.17090262,-0.0150354905,0.041516133,0.018382488,0.05624021,0.044646762,-0.06544443,-0.069740795,-0.0427793,3.6409762e-33,0.036040086,0.0490281,0.019934973,-0.022164319,0.06408494,0.028731054,-0.11604346,0.029523673,0.04888384,-0.016047556,-0.060466498,-0.035905443,0.04929263,-0.07124996,-0.044373345,-0.052112076,-0.008541601,-0.0069031906,-0.015961738,0.0008716187,0.0244616,0.12015598,0.017518623,0.045310564,0.018029455,0.024113333,-0.027881328,0.008953812,-0.02309046,-0.018674681,-0.009072329,-0.049321864,-0.08165489,0.0024392055,0.055752404,-0.040476743,-0.04691101,-0.064310506,0.026585288,0.069080435,-0.0053340374,0.030997757,-0.061183345,0.023768831,0.075177215,-0.059456505,-0.0014371715,0.03629546,0.031507682,0.07161875,-0.014771142,-0.0035291875,0.10740931,-0.011921765,-0.016069075,-0.017274827,-0.011932098,-0.03520224,0.058438126,0.107104026,0.039075095,0.053166892,-0.0044716573,-0.01932719,-0.09215524,-0.017973993,-0.055583008,-0.08254712,0.018784026,-0.010639034,0.04690152,0.025332842,0.0895584,0.03834842,0.026750961,-0.03486903,-0.027007809,0.019816479,-0.00073313294,-0.057182264,-0.009167736,0.06951123,-0.012725164,0.028054243,0.013072683,0.06795429,-0.00574663,-0.08049384,-0.010923294,0.020653946,0.08277042,-0.034554627,-0.030280568,-0.029354151,0.078340925,-4.503612e-33,0.1327469,-0.124920815,0.04360479,-0.08413974,-0.0070464946,0.028144548,0.074997336,-0.03942356,0.009383669,-0.0033355856,0.07571241,0.035233237,-0.015958756,0.016874425,-0.009510771,0.016992256,0.1255415,0.039198108,-0.035997923,-0.014634307,-0.0886716,0.023252713,0.01599563,0.031863865,0.012187138,0.031382505,0.02950636,-0.018057024,0.06417206,0.01939693,-0.017614903,-0.020037523,-0.06692967,0.002810872,0.04041257,0.12850344,-0.052607797,0.0731416,-0.02307525,0.04225846,-0.032663286,0.028051933,-0.03837465,-0.03707543,0.0659831,-0.0066718115,-0.07308373,0.026852457,-0.04082086,-0.13120621,0.123872936,0.04420719,-0.0045506693,0.075731,0.021298394,-0.021272859,0.058867127,0.007867192,0.023305327,0.044675842,-0.02032868,-0.06533223,0.035622615,-0.001944348,0.05993642,0.035010576,0.005181453,0.04192493,0.060977187,-0.01653745,0.044469357,-0.017433386,0.061976742,0.014833725,-0.029644735,-0.06569405,0.01084445,-0.019594831,-0.011239152,-0.056995526,-0.00893412,-0.010422644,-0.019926658,-0.042582832,-0.019108243,-0.09545146,0.042710897,0.0586657,-0.026071543,0.039318785,-0.016482577,0.0152972415,0.0034258286,0.072869085,0.123752095,-4.2762977e-08,0.030216927,0.0016337438,0.019223053,-0.031358182,0.05843337,0.016818454,0.0056294617,-0.050155375,0.030567495,-0.03132201,-0.020223472,0.08738814,0.09640926,-0.00019928583,0.037070855,0.08907336,-0.11092886,0.03726389,0.041083574,0.039217222,-0.00057003496,0.021738078,-0.1748829,-0.016842708,-0.0016778162,-0.048923973,-0.011456812,-0.035304874,-0.00430753,-0.052504443,0.07144242,-0.0072649056,0.018010596,-0.013431217,0.015191767,0.015509551,0.010584976,0.042769074,0.017131496,-0.015006938,-0.11813772,-0.040920433,-0.0032826476,0.07576219,-0.041951124,-0.024517693,0.024627386,0.0025561412,-0.04617842,0.013584925,0.07424235,0.0417819,0.0076448554,-0.10746194,-0.054155666,-0.04044002,-0.02402463,-0.09394148,-0.003848608,0.030448267,0.041789778,0.012194198,0.11113432,0.021530667 +1.1.1.303,"The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the yeast Saccharomyces cerevisiae [1,2]. Different from EC 1.1.1.304, diacetyl reductase [(S)-acetoin forming].",384,0.99999994,-0.06340968,-0.036768846,-0.13338207,-0.01856037,0.08565011,-0.017090052,-0.0876984,-0.023897909,0.05205597,-0.02215381,-0.039327536,0.016842546,-0.097738415,-0.0296397,-0.115360916,-0.04237855,0.0073032402,0.0065031988,0.01955567,-0.052174374,0.037507508,-0.009714701,-0.038075678,-0.010536892,0.062174153,-0.029223064,0.020939855,0.021465955,-0.075851366,-0.18237756,-0.012231903,-0.044036184,0.0040018777,-0.0148811145,-0.027130436,0.0882337,-0.022634989,0.0012476011,0.022384634,0.0389693,-0.006149442,-0.03518123,-0.10967742,-0.01912341,-0.058168873,-0.016164836,-0.09709079,0.052721977,0.06200121,-0.03255383,0.031613078,0.008019087,-0.01390215,-0.004398028,-0.003679312,0.03523062,-0.03596741,0.016739625,-0.021293646,0.0018378384,0.005151003,-0.035099685,0.00817112,-0.0046523963,-0.029868146,-0.028701039,0.09321709,-0.07507266,0.014359801,-0.05895176,-0.021523638,-0.08842822,-0.05129346,0.0008776057,0.048074283,0.031188264,0.017240608,0.0063774996,0.034600426,-0.046028964,0.0605775,0.020975618,0.061882503,0.010414652,0.08274428,-0.03577936,-0.043207973,-0.027515132,0.0927166,0.03627638,0.011776171,0.02220967,0.023377607,0.01733386,-0.0015663134,0.021830982,0.023903996,0.088439964,0.02449754,-0.06525569,-0.00395776,0.08957375,-0.0014693488,-0.045421146,-0.015660282,0.008834977,0.0043583675,0.0783026,0.035119884,-0.02337088,0.028144522,-0.021915963,0.09760745,0.034193825,-0.007897891,0.005714021,0.0051908647,-0.036545195,-0.12893403,-0.066213556,0.019516202,0.030644348,0.036474224,0.036567673,-0.042515527,-0.014365213,-0.029543806,4.510606e-33,0.015993055,0.040699452,-0.040460043,-0.028211167,0.03557197,0.028852707,-0.06617276,0.060572427,0.01926363,-0.038498875,0.05102656,0.009145987,-0.009069985,0.0022489561,-0.051518507,-0.03935163,0.07957994,-0.013339529,-0.0035911244,-0.021680959,-0.04629981,0.055579506,-0.07931837,-0.03698124,0.062006254,0.058705907,-0.05405794,0.03366196,-0.023721213,-0.023416901,0.010730714,-0.104660526,-0.03348378,0.029034873,0.00013162545,-0.0061591263,0.019083776,0.010663224,-0.023930859,0.07941037,-0.047788482,0.041872073,-0.06531954,-0.06685926,0.019245636,-0.020971876,0.0035680572,0.09788952,0.016344817,0.062328666,-0.04068527,-0.012574112,0.12563159,-0.04907824,-0.010399588,0.045879,-0.051516697,-0.0031706318,0.027132561,0.07268827,0.03722594,0.1076964,-0.010729322,0.03337324,-0.028176138,-0.025075,-0.07183881,-0.022106763,-0.011608809,0.02304341,-0.05127988,0.038393673,0.10176498,-0.0070493715,0.020829922,-0.02579223,-0.067007475,0.030431224,0.039434485,-0.0061830287,-0.031564057,-0.016597506,-0.020033017,-0.026949653,-0.050237384,0.07078898,-0.015009208,-0.09149432,-0.0211675,0.069462225,0.059397098,-0.047866594,0.019140424,0.0023595467,0.14650059,-5.0950587e-33,0.10143722,-0.06409925,-0.0061586346,-0.07985373,-0.044175062,0.14085752,0.08787144,-0.022675423,-0.029086737,-0.026098266,0.014982505,-0.052991282,-0.04620826,-0.04591106,0.023084866,0.030842565,-0.010404445,0.12762484,-0.064149655,0.017197229,-0.037066836,0.1181411,0.0024788226,0.065735556,0.07766399,0.022415895,0.02002374,0.045073587,0.04070144,0.00088692637,0.046269927,0.061389804,-0.016737644,-0.028160531,-0.03593463,0.07873268,-0.115282394,0.01207221,-0.0411194,-0.013687452,0.017667176,0.060776476,-0.0570681,0.0042031882,0.03325498,0.058042724,-0.057631455,0.034451287,0.060900684,-0.11766118,0.030422803,0.02398455,-0.015935468,0.06458546,0.020752793,0.03651777,0.08586086,0.027489325,0.026684305,0.004676441,-0.028512457,-0.04785355,0.054491796,0.0025020326,0.028469974,0.02746516,-0.02954453,0.037258163,0.08610967,0.013167513,0.06767462,-0.015172818,0.002283138,0.060084652,-0.054665003,-0.02770597,-0.051228825,-0.04882337,-0.052284155,-0.058835782,-0.044447433,-0.04905587,-0.025385331,-0.043913458,-0.06520215,-0.08578381,0.0029032892,0.049738944,-0.054350592,0.050650973,0.019397553,-0.06149091,-0.086683236,0.065967485,0.08660958,-4.2822677e-08,0.06607346,-0.056498,0.1002538,-0.051148668,0.036112398,0.02213245,0.10613395,-0.0036491216,-0.010265154,-0.031016007,-0.048377387,0.0714586,0.10942462,0.026902705,0.05331649,0.050631717,0.003204874,-0.0005100804,0.044035304,0.013385899,-0.012415305,-0.061587997,-0.15439324,0.047105093,0.0033786772,-0.049024124,0.033756908,0.06075209,0.04582799,-0.050700247,0.011948222,0.03887929,0.05372302,0.010704759,0.02517583,-0.017330687,-0.018701144,0.01612086,-0.037999626,-0.017195964,-0.07657346,-0.014422219,-0.053911857,0.038966924,-0.0733356,0.0043332423,0.041100807,-0.010137659,-0.0032169765,-0.018434677,0.046009853,-0.016557537,0.03950567,-0.050059013,-0.06783817,0.03901728,-0.05424381,-0.02124514,0.0051469374,0.003683395,0.029390855,-0.03535367,0.12165407,-0.08776984 +1.1.1.304,"The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae [1-3]. Different from EC 1.1.1.303, diacetyl reductase [(R)-acetoin forming].",384,0.99999994,-0.079009905,-0.025088383,-0.15544003,-0.025699867,0.04742408,-0.022079632,-0.105509005,-0.013748039,0.0470391,-0.042819448,-0.051013242,-0.027183345,-0.03922206,-0.004312549,-0.07033432,-0.031269282,-0.0047197603,-0.0031693303,0.007209532,-0.055984844,0.020277733,0.026572559,-0.062712364,-0.039649118,0.037470624,-0.008334641,0.06737353,-0.0024433897,-0.105233684,-0.13888662,0.0098294495,-0.09620316,0.034310732,-0.040592954,0.036432717,0.114562325,-0.06299331,0.00034464264,0.08093893,0.040878,-0.003657789,0.0045032552,-0.06371121,-0.016988188,-0.078658804,-0.023794947,-0.08244266,0.076586656,0.054898553,-0.057356946,0.017127048,-0.007935231,-0.040766727,0.043614753,0.039904416,0.019660352,-0.04895137,-0.028316619,-0.037133068,-0.030755099,0.02613498,-0.051831365,0.048768084,-0.027351173,-0.06774291,-0.024243725,0.08818298,-0.09521589,0.028463412,-0.085311584,-0.06323569,-0.066212945,-0.033751767,0.042547945,0.0003176117,0.019013746,-0.023864053,0.058614418,0.0503122,-0.07572827,0.07127738,-0.005593991,0.023759743,0.0479111,0.085396074,-0.03542555,-0.023941714,-0.04318034,0.077421315,0.04136744,0.039763205,0.0037948263,0.04728185,-0.018234503,-0.027528038,-0.047226757,0.032269035,0.061845284,0.020082908,-0.077859774,-0.036075983,0.065714344,-0.011319763,-0.02968869,-0.06999512,-0.05316771,0.015077999,0.09906327,0.07554967,-0.02781866,-0.0060775834,0.007657042,0.08626338,0.015866973,-0.016272621,0.02543062,0.03540935,-0.07744684,-0.14103076,-0.023248885,0.009480825,-0.040694747,0.06741116,0.019240368,-0.015454108,-0.0065689506,-0.058708787,5.6978735e-33,0.029125676,0.02120178,0.0139342835,-0.044446576,0.031344984,0.012389172,-0.07223991,0.05036173,0.06942766,-0.07187277,0.010251254,-0.034399536,0.019108104,0.008936938,-0.030280093,0.023998503,0.009554332,-0.008199076,-0.0186277,0.016796181,-0.030338127,0.039002124,-0.040481333,-0.010871758,0.0567357,0.073665194,-0.048431758,0.002842826,0.003977759,-0.007022191,0.05390483,-0.12103968,-0.067354396,0.024392098,0.021129576,-0.00042763498,-0.020159125,0.009588484,-0.037082132,0.05990022,-0.06628863,0.039911766,-0.07326768,-0.067494065,0.042084545,-0.025690747,-0.019068493,0.14001839,0.016484398,0.062418208,-0.008735241,0.005932563,0.117371075,-0.060177818,-0.0057027983,0.041378066,-0.014459083,0.015045729,0.049605325,0.059114944,0.08740331,0.12925223,-0.009074814,0.040039577,-0.030510236,-0.018807216,-0.0786725,0.0001865503,0.00838205,0.05231167,-0.03181536,0.024023455,0.06195913,0.022070225,-0.0179903,-0.020319749,-0.05309802,0.013325385,0.06278138,-0.027137367,-0.0042529157,-0.0077239163,0.019839892,-0.05751409,-0.046018366,0.04411561,-0.013481476,-0.08895454,-0.023543946,0.1054709,0.07100651,-0.02846008,-0.06379925,0.016510814,0.107821114,-5.9520583e-33,0.11869643,-0.10362665,-0.020742245,-0.10414559,-0.021709936,0.119304866,0.062437225,0.028102146,0.021806717,-0.032353077,0.04820983,0.020750495,-0.030689765,0.0028710861,0.04533054,0.013335254,-0.0006424249,0.1081985,-0.062663905,-0.01118585,0.019151969,0.048193105,0.011733408,0.010817869,0.03373944,0.053381123,-0.0110213915,0.06931286,0.02799832,0.006507217,0.062383916,0.115357056,-0.023986949,-0.04165593,-0.06815818,0.049453706,-0.088589996,-0.00999956,-0.00672595,-0.054471206,-0.010477677,0.029708661,-0.0339486,0.030874897,0.03720747,0.023184836,-0.038914777,0.006703157,0.03716487,-0.11218328,0.025392195,-0.0019616904,-0.0098759355,0.037191294,-0.011776215,0.06696203,0.061713748,0.01624072,0.024508046,-0.01677547,-0.049494084,-0.0429928,0.071265586,0.024821112,-0.012101502,0.02856379,0.039213315,0.07491261,0.118280225,0.00306524,0.0457761,-0.04009087,-0.010980691,0.039507754,-0.05426317,-0.018812628,-0.050133854,-0.0097568175,-0.034465786,-0.021539219,-0.05794448,-0.04319231,-0.041732322,-0.05388232,-0.03556865,-0.084863074,0.003903101,0.049017623,-0.05837774,0.044996127,-0.020106552,-0.03961791,-0.07866531,0.061580732,0.074525006,-4.6016858e-08,0.049998485,-0.080035694,0.088664696,-0.0033688596,0.050556056,0.024151785,0.050776307,-0.0063122134,0.011445875,-0.067182295,0.018824814,0.06239499,0.067458235,0.009318352,0.037753116,0.053380083,-0.034521785,-0.03444538,0.03916167,0.023871208,-0.032266617,-0.05233782,-0.11950521,0.028869355,0.032854933,-0.06281883,0.03243372,0.043927316,0.014875215,-0.04285794,-0.00023791926,0.06046823,0.07160035,0.00038004108,-0.01811425,-0.01749573,-0.0015309628,0.021366345,-0.02923525,-0.005853436,-0.03922316,0.015921066,-0.07995859,0.028120207,-0.015096399,0.035236128,-0.022405636,0.027314782,-0.042641997,-0.055036448,0.01887477,-0.016824756,0.032126043,-0.016632007,-0.070915714,0.092042245,-0.04345061,-0.0445392,-0.008949251,0.042695142,0.008369713,-0.03253315,0.12777305,-0.03626403 +1.2.1.78,The enzyme is involved in phenanthrene degradation. ,384,1.0000001,-0.035641916,-0.03140529,-0.04558429,0.0016243254,0.07983411,0.028220449,-0.100837015,0.03564702,0.04199039,-0.0025343806,0.00057654636,0.004548716,-0.07482977,0.03133108,-0.049996775,0.024822826,-0.09084775,0.00874903,0.04252845,-0.00527688,0.073622786,0.008813725,0.009959726,-0.0034522451,0.05949997,0.007916796,0.010302905,-0.06435117,0.004665264,-0.007930755,0.019812718,-0.075805806,0.022756074,-0.0052176774,-0.034349293,0.10066252,-0.06225659,-0.084026106,0.025944619,0.026334766,0.015297641,0.034605324,-0.09092038,-0.02224712,-0.008373731,-4.3668508e-05,-0.0674279,0.05539889,-0.019879868,0.0069045075,-0.077237,-0.006685532,-0.023719672,-0.010839262,-0.022776408,0.043490704,-0.040466126,-0.023507029,-0.00667959,0.05926991,0.023502745,0.018882062,-0.02707585,-0.03943965,0.08906875,-0.061973143,0.034314703,-0.018237159,0.062394895,-0.05685183,-0.093411334,-0.04750116,-0.0010789647,0.020948317,0.047624912,0.073351614,-0.004302668,-0.054677386,-0.049858775,-0.01516222,0.05810738,-0.026323901,-0.0006987227,0.036597516,0.07725775,0.05504399,0.01654112,-0.050691612,0.017544748,0.018046238,0.054175436,0.06301674,-0.016187172,0.032658312,-0.032399613,0.012597704,-0.040088627,0.012350941,-0.01725581,-0.004539817,-0.025175402,0.04936741,-0.08477012,-0.06781807,-0.08438997,-0.038387466,0.033831168,0.09295752,-0.022913069,-0.013767504,0.03196263,0.037402686,0.05484426,-0.029661883,0.02376805,0.0984624,0.029438104,-0.04120937,-0.09083238,0.042216398,-0.023147989,-0.051830973,0.0016903317,-0.00027370788,-0.03943115,0.0038952858,-0.038135536,-1.9571516e-33,0.06688175,0.004250201,0.00335768,-0.030645436,-0.018344142,0.0019510739,-0.07023865,0.033114925,0.014594928,-0.1282629,0.026013808,-0.1264273,-0.0047144624,0.008821193,0.014544581,-0.05447281,0.056700442,0.01836228,0.10809708,-0.015584079,-0.0037812681,0.03297071,-0.019947002,0.07691462,0.06925038,0.043117404,0.0038962362,0.04892162,-0.09454907,-0.0155042615,0.060803242,-0.12322289,-0.13248795,0.0007077775,-0.011949183,0.0031399273,-0.0838371,-0.054472197,-0.050469257,0.02838381,-0.042157754,-0.006681901,0.032022264,0.10187847,0.031003168,-0.007921841,-0.018996326,0.13663262,0.011255959,0.026948702,0.041665226,-0.004278809,0.102701806,-0.0050367895,-0.08066684,0.07886903,0.018577153,-0.11661208,0.036997683,0.0022982473,0.04352933,0.09845971,-0.040734522,0.043803226,-0.028877452,0.04561853,-0.055829562,-0.034820158,-0.0013983615,0.09432811,-0.07288912,-0.043702397,0.052778587,0.03223342,0.03531605,0.0043948973,-0.0861919,0.0034623342,-0.005984909,-0.080589846,0.02735341,-0.006647451,0.016303819,0.050122555,-0.057947718,-0.03532046,-0.0067513045,-0.04303268,0.038785778,0.052713156,0.091104954,-0.086894795,-0.066121146,0.019608023,-0.012544234,1.5649336e-33,0.03486543,-0.08203345,-0.020407055,-0.0039183074,-0.028907683,0.023274159,-0.047471397,0.04940729,-0.058953732,-0.060510926,0.046365738,-0.028005168,-0.010923137,-0.038420044,0.04698915,0.0611545,0.034961767,0.0036348577,-0.00138923,-0.0050964556,-0.017680582,0.07493518,0.04272167,-0.00138045,0.087649345,0.03582527,0.025015913,0.043370195,0.10359055,-0.024204599,-0.006749652,0.026778705,-0.04504711,-0.022363517,-0.026205268,0.09141681,0.007633602,-0.033423327,0.0064692567,-0.009756894,0.022665938,-0.0026688487,0.022712436,0.006122094,0.038481176,0.06759587,0.0020757932,-0.043008093,-0.011717164,-0.03134638,0.05123138,0.08122122,0.03308994,0.023206748,0.04607935,0.059631713,0.012718289,-0.038119737,0.0052680466,-0.018592298,0.03607295,-0.096229926,0.026748236,0.05152769,0.04648161,-0.009105393,0.05751686,0.09470504,0.04613141,-0.025363905,0.09255372,0.018937,0.07886455,0.039398722,-0.11202131,-0.01074764,-0.06505765,0.030412069,-0.008516516,0.03165088,-0.036131248,-0.015754519,0.01888904,-0.107084416,0.011730512,-0.079972275,0.044988193,0.081913956,-0.016426453,0.025122523,0.0106505975,-0.100932695,-0.05891719,-0.006140431,0.06385704,-1.7818792e-08,0.089072086,-0.06579349,0.043055892,-0.083044894,0.028788472,-0.04889807,0.05903289,0.017341094,-0.014250861,0.018353121,-0.056130726,0.040541008,0.02002527,0.016364692,0.010747927,0.00095333485,-0.067974225,0.011507794,-0.045840096,0.025813006,-0.11451584,-0.006245852,-0.14031202,0.05437046,0.016826438,-0.033398453,0.048439465,0.035074797,-0.012956728,-0.028077694,0.0434778,0.040076748,0.0990219,-0.04309313,-0.104334295,0.05619763,0.03198939,-0.038672183,-0.041463535,0.044070628,-0.07313176,-0.042986188,-0.03362637,0.042557277,0.07527164,0.015595335,0.052319232,0.015799271,-0.00015893359,-0.047359165,0.029446982,-0.0040635057,-0.03975978,-0.02155739,-0.09942644,-0.0239132,0.025152814,-0.046212193,0.013500535,-0.074239455,0.032351788,-0.0050045582,0.20171602,-0.021324305 +1.4.5.1,"An iron-sulfur flavoprotein (FAD). The enzyme from the bacterium Helicobacter pylori is highly specific for D-proline, while the enzyme from the bacterium Escherichia coli B is most active with D-alanine, D-phenylalanine and D-methionine. This enzyme may be the same as EC 1.4.99.6.",384,1.0,-0.09197626,-0.12097261,-0.12682286,-0.020766357,0.09052001,0.020459076,-0.039829087,0.11491792,0.040653184,-0.012886645,0.017928982,0.022531288,-0.105480455,0.027989643,0.0020216173,0.028432457,-0.04443845,-0.02914073,-0.044525832,-0.034127295,-0.02996143,0.025194958,0.047706272,-0.0605459,-0.00072224514,-0.009727204,0.08586328,0.017097255,-0.046753366,-0.009067405,0.06634318,-0.04010916,0.07854155,-0.036169495,0.041457243,0.0067245164,0.03503431,-0.011044913,-0.02432408,0.01152792,0.024170732,0.024267724,0.034530465,-0.047440812,0.022240423,0.002817544,-0.07998824,0.07884095,0.017765263,-0.008715989,-0.011792026,-0.05174886,-0.0761353,0.014994479,-0.014466429,0.03800434,0.025251254,-0.098914936,-0.012274172,-0.034432862,-0.006806588,0.0036407073,0.066574015,-0.004908398,0.04128818,-0.014276427,-0.029999508,-0.050209623,0.057742078,-0.06680506,-0.06270048,-0.056335665,-0.070517935,0.087829806,0.024466995,0.0007399162,-0.03392203,-0.06715475,0.06493351,-0.06632972,0.042644423,-0.025325334,0.05155555,0.056751233,0.03635963,-0.00263342,0.019217988,-0.046902467,0.0068630795,0.038652554,0.023774985,-0.03218629,-0.014462369,0.013542125,-0.10215791,0.04612237,0.0026030235,0.01762348,-0.06332057,0.004347617,-0.051235016,0.0195711,-0.035697147,-0.026430365,-0.058699965,-0.03509163,0.00047414046,0.12564538,-0.026106179,-0.028334241,0.028307868,-0.044405874,0.025272664,-0.02607853,0.011250492,0.0014162067,-0.006093434,-0.03469398,0.025989942,-0.012578642,-0.021566313,0.061340995,0.09550503,0.11187437,0.044783153,0.03522958,-0.12221599,2.727541e-33,0.09342911,0.007733429,0.033468872,-0.054748654,-0.023701522,-0.013201115,-0.13578664,0.03418132,0.02138501,-0.043172475,-0.11147495,-0.06422486,0.047292273,-0.048907183,0.030129885,-0.004261868,-0.021259265,-0.008119997,0.054671153,-0.038535483,0.053135272,0.06847199,0.04205992,0.023864185,0.07470945,-0.012653136,-0.03783718,0.09879973,0.0028329073,0.02435498,-0.04739466,-0.116476856,-0.030314129,0.04627382,-0.037314553,0.06973188,-0.088195525,-0.06369078,-0.083558075,0.050015982,0.03749259,-0.0040131556,-0.008075826,0.0063018887,0.019070946,-0.056561057,-0.07298482,0.10508949,-0.030233687,0.09116241,0.018344022,0.003812764,0.10500724,0.017866736,-0.0663637,0.0018905097,-0.013910985,0.01923816,0.06672544,0.039446607,0.04220608,0.11455705,-0.019411363,0.09291982,-0.0043893056,0.020500658,0.021354768,-0.039350446,-0.014165638,0.11319562,-0.016774353,0.012981948,0.11285331,-0.010660618,0.015412088,-0.09070943,-0.06606536,-0.01960212,0.008792308,-0.008264547,-0.055352148,-0.0064743874,-0.028862363,-0.00697886,-0.07134575,0.02180548,-0.08330215,-0.04354651,0.010153432,0.003406888,-0.010484525,-0.034910113,-0.015271205,0.06050018,0.044437993,-2.4174058e-33,-0.033876486,-0.05088138,0.057326194,0.031894423,-0.010674936,0.061318684,0.03844089,-0.0037003385,0.043267336,-0.023199204,0.08875641,-0.032143984,-0.018493643,-0.05741855,0.06785464,0.056102414,-0.091083445,0.009836732,0.0525674,0.02746133,-0.028574433,0.0014542709,0.027616682,0.03717422,0.028374298,-0.008501508,0.040223643,-0.00446093,0.008864415,0.007219844,0.030467434,0.09826846,-0.06753239,-0.04634113,-0.102628656,0.038445096,-0.051145848,0.022542989,0.019969068,0.022940097,-0.027041469,0.040727004,0.0060913265,0.07119353,0.008223309,0.08371641,-0.031063825,0.014318307,0.077676535,-0.04873095,-0.03041956,-0.019974977,0.056154236,0.037877817,0.012353292,0.09206035,0.047827523,0.108949326,-0.102552935,0.049179744,7.510458e-05,-0.10934634,0.059880354,0.023306036,0.067842625,0.015770989,0.015292056,0.077221245,0.0075019104,-0.017941313,0.10611952,0.016364343,-0.031852413,0.051381882,-0.022946104,-0.07338363,0.013021286,0.08207223,0.027365547,0.07425086,0.009995281,-0.017968612,-0.023143994,0.046204977,-0.07270667,-0.05198696,-0.01733056,0.06335515,0.022504384,0.066228405,-0.044501714,0.028793385,-0.0026638755,-0.046741985,0.03678153,-3.6341614e-08,0.041284673,-0.06051779,0.024610048,-0.008800247,0.084215485,-0.0005752204,-0.05168565,-0.053743027,-0.004525944,-0.012141327,-0.054161552,0.12805064,-0.07234368,-0.047063176,0.033266988,-0.0011075569,-0.0461093,0.02206778,-0.028383458,0.041873347,-0.022606187,0.02025292,-0.08594039,-0.023804922,-0.045287315,-0.06521144,0.03278306,-0.0026948072,-0.0026570312,0.015604723,-0.047612708,-0.006115795,-0.03637181,-0.04569231,-0.06641656,0.008420091,0.0037988902,-0.0655918,-0.040835347,0.10001583,-0.0051984936,-0.038528055,-0.033247795,-0.0064098467,0.023543388,0.011940883,-0.018453605,0.0070350277,-0.07585434,-0.012573506,-0.017278722,-0.016321467,0.01890985,-0.05857478,-0.07887331,0.08892881,-0.021568734,-0.11935765,-0.047677867,-0.012710509,0.07057615,-0.021573745,0.099425524,0.012330357 +1.5.99.13,A flavoprotein (FAD). The enzyme prefers D-proline and acts on other D-amino acids with lower efficiency. ,384,1.0,-0.09392509,-0.111673385,-0.09744383,-0.009169928,0.08678369,0.00980152,0.003814683,0.09566621,0.063884355,0.0032772354,0.0038509013,0.06161728,-0.0876656,-0.010742591,-0.046374854,0.047297478,-0.037408754,-0.03627928,-0.076531,-0.039961305,-0.00088923896,0.010459066,0.03393978,-0.014779451,0.018066065,-0.024717543,0.05586416,-0.009943559,-0.01827773,-0.030874943,0.05008925,0.003073654,0.06487136,0.0067288904,-0.027734,0.035661805,0.023173358,-0.007089411,-0.03171511,-0.0030701272,0.053289775,0.011987173,0.021865865,-0.034254733,0.048143268,-0.0008900746,-0.07957983,0.074000634,0.023057623,0.0742487,-0.014087998,-0.076201774,-0.12674753,0.04113828,-0.009543585,0.08318932,-0.008772515,-0.041299723,-0.03176641,0.007843878,-0.02369761,-0.015529481,0.06244528,0.001910221,0.077746876,-0.06670345,-0.05159495,0.016827647,0.06867646,-0.04099505,-0.0078110956,-0.03536086,-0.071746096,0.07613715,0.038175784,-0.018400287,-0.0553302,-0.047169175,0.06631869,-0.04091016,0.070382066,0.026213521,0.04286569,0.09962434,0.048340484,0.010162171,0.0042089233,-0.02386001,-0.01216136,0.03589707,0.005388724,0.006348217,-0.035083175,0.034710053,-0.08639236,0.05259224,0.023123918,-0.052444264,-0.105180666,-0.013011854,-0.021138327,-0.0090458505,0.040151626,-0.01979726,-0.08928254,-0.047766406,-0.025562404,0.04620668,-0.046203475,-0.051804215,0.037055895,-0.03952332,0.030593676,-0.0379698,-0.008663525,-0.008811824,-0.020121783,-0.035384923,0.025403127,-0.028489556,-0.053154442,0.09428089,0.075830065,0.0987957,0.0005786304,0.045011844,-0.059620578,-3.5879685e-34,0.059375037,-0.026575848,-0.026861986,-0.018744724,0.005387329,-0.014956937,-0.08381886,0.02594408,0.020185258,-0.02737142,-0.08207899,-0.06378835,0.024721554,-0.033115204,0.08270554,-0.0046522287,-0.0031657068,-0.028984375,0.028105695,-0.06573976,0.02710863,0.08749542,0.013690003,0.053666115,0.057161268,-0.04434259,-0.047372624,0.057785712,0.01836555,0.031823236,-0.04756198,-0.0996674,-0.027396368,0.0120229665,-0.036824934,0.0636068,-0.066588774,-0.11077838,-0.077565745,0.08971432,0.006836735,-0.04633844,-0.02383294,0.019540891,0.036503542,-0.030800665,-0.069565505,0.110693604,-0.043989982,0.08917187,0.05455561,-0.032137338,0.1339681,0.04413709,-0.10587957,0.009321533,-0.052182127,-0.0043856977,0.04342131,0.02875226,-0.01814946,0.03946557,-0.0290426,0.10555706,-0.048349645,-0.0056768395,-0.044371534,-0.043645997,-0.004063091,0.09759052,-0.00038805345,-0.015066569,0.109285675,-0.0011361856,0.040776573,-0.0679253,-0.06529411,-0.025659768,0.011129453,-0.013566148,-0.026765961,0.017287621,-0.059401948,0.027764106,-0.032912623,0.010237861,-0.033031162,-0.053873736,0.018378265,-0.017943867,0.011798804,-0.03534409,-0.02739009,0.041822985,0.046021424,-1.722259e-34,0.019328238,-0.115523666,0.04058586,0.07668546,0.0042196666,0.04315644,0.046136618,-0.061382107,0.063598,-0.03204684,0.025412584,-0.084424905,-0.043617055,-0.015914844,0.04936288,0.06262617,-0.109652705,0.020328008,0.049395513,0.016920732,-0.023803266,-0.014950102,0.051867567,0.08280791,0.023176212,-0.022392455,0.027513068,-0.0150639145,0.011471055,0.038305048,-0.0013115321,0.048739273,-0.064004414,-0.04658555,-0.076181434,0.08126503,-0.013545962,0.0060435934,-0.021184009,0.04117939,-0.046756573,0.048837125,0.06269119,0.04103571,0.03757985,0.069140755,-0.022315865,0.043049328,0.039345127,-0.039156016,0.026855351,0.0020624893,0.037617702,0.09207554,0.0034395899,0.039218027,0.03652166,0.10148077,-0.06288318,0.035458986,0.011395482,-0.14438592,0.009656995,0.019765839,0.06417677,0.045671117,0.038295463,0.07832758,0.01292783,0.002430252,0.13432889,0.0022531427,0.0073412606,0.06459722,-0.004342562,-0.024104647,-0.020110618,0.0718822,0.0032447476,0.040099844,-0.03416683,-0.019577438,-0.007102267,0.028493814,-0.08801608,-0.074469864,-0.0053809765,0.07416307,0.036328442,0.05970071,-0.030888028,0.027240226,-0.04542105,-0.031905252,0.059854083,-2.4551229e-08,0.045725,-0.045015894,0.023357973,-0.021880098,0.09904953,0.009976639,-0.0141778905,-0.020319186,0.007879681,-0.058133733,-0.07164835,0.13552523,-0.07047149,-0.007813151,0.054840557,0.0056807925,-0.00040873548,0.04482142,-0.04317757,-0.022374721,-0.05403483,0.039754458,-0.10978734,-0.0044717374,-0.063957624,-0.05022539,0.02661457,0.032959834,0.037071783,-0.0007628247,0.014592222,0.025634173,0.010640717,-0.08729466,-0.088888146,0.05774687,0.053808868,-0.057530947,-0.034416772,0.076702066,-0.05293066,-0.031291094,0.008365736,-0.05872554,-0.026690455,-0.03655363,0.030032195,-0.0034935863,-0.045259885,0.018232115,-0.022467766,-0.023485359,-0.0077622565,-0.02863321,-0.07990294,-0.00014874754,-0.01976368,-0.09146797,-0.054065492,-0.08326142,0.022877919,0.04868783,0.13566123,0.011499623 +1.14.13.113,"A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase. ",384,0.99999994,-0.024843639,-0.015188529,-0.08118726,-0.009590233,0.066712,0.07546026,-0.05331984,0.025990196,0.06515959,-0.058686882,0.024973474,-0.07078375,-0.06844767,-0.04133305,-0.07643497,0.08022211,-0.091239125,-0.026370801,-0.0056329872,-0.038489852,0.052936595,0.043685358,0.0060816067,-0.017336952,0.031050753,0.019414118,0.06693376,-0.018004121,-0.037201565,-0.08086134,0.05059451,-0.042151626,0.05697728,-0.03682914,0.007155726,0.067865334,-0.031484004,-0.109131575,0.0013653835,0.04020105,0.04240617,-0.030968111,-0.01564332,-0.023182277,0.0025228634,0.04141134,0.0399066,0.056127507,-0.027460163,-0.01803321,-0.033060174,-0.087462,-0.0864425,0.012710073,0.02872221,0.0006362832,-0.061702482,-0.0046724877,-0.0524019,-0.005979138,0.019700238,-0.009761489,0.031006057,0.008903149,-0.020564618,-0.086219646,0.004630376,-0.07715517,0.009731619,-0.10600601,-0.055669703,-0.11009662,0.019291094,0.056789644,-0.015588297,0.042742368,-0.03461172,-0.02580374,0.046819758,-0.034281693,0.055670958,-0.032921944,-0.04784051,0.11061288,0.05850441,-0.03760437,-0.02850285,-0.025909051,0.009524862,0.008029981,0.0061952653,0.0016280112,-0.00019362575,-0.01046241,-0.041807797,0.075816326,0.06093799,0.026022213,0.022208357,-0.042189136,-0.06976431,0.060305987,-0.0006832035,-0.09243611,-0.04641965,0.027467642,-0.0077329925,0.10396837,0.042921405,-0.019775543,-0.055100355,-0.071140535,-0.0037470725,-0.03934635,0.061855633,0.018015843,0.05609718,-0.08418416,-0.03663083,-0.0041772136,0.008814533,0.004358231,0.01743477,0.104634166,-0.052873448,0.031175414,-0.09508409,4.3481247e-34,0.09925944,0.031236067,-0.033628665,-0.057604697,-0.0012912861,0.013479928,-0.031662777,-0.011348573,0.001936894,-0.115400486,-0.089234665,-0.01768165,0.013684826,-0.045017406,-0.014906346,-0.010882299,-0.047127765,0.04567218,0.05865152,-0.0068113594,0.042388875,0.050191637,-0.07466358,0.05748339,0.007853148,-0.00979362,0.037683718,-0.0437135,-0.025110148,-0.010044888,-0.0060774917,-0.009866463,-0.054275297,-0.021570181,-0.011991204,-0.016721046,-0.058408827,-0.022874258,-0.07296205,0.070666425,-0.041241508,0.02107539,0.023051232,-0.062084597,0.08479708,-0.052519143,-0.0970174,0.12087457,0.035837412,0.07542652,0.025241053,-0.0344066,0.1904927,0.01607298,-0.0060804863,0.05472963,0.011279878,0.046095576,0.046880398,0.04110337,-0.04996394,0.1666095,-0.007998231,0.04969537,-0.04061661,0.036778692,-0.048231326,-0.025898691,0.008286895,0.089944184,-0.01266406,0.012445917,0.094961114,-0.024121275,0.036511686,-0.07488586,-0.12169882,0.036572587,-0.009468314,0.025856165,-0.02400261,-0.01352272,0.04545497,0.010228766,-0.013120039,0.03230702,-0.025453707,0.039976463,-0.04114015,0.056649566,0.08448816,-0.02600435,-0.039345864,-0.0035582054,0.058174536,-6.422795e-34,0.09599317,-0.12628768,0.023167329,-0.01278769,0.011185976,0.08992588,-0.0016050902,-0.014586236,0.050518885,0.024462081,0.028392633,-0.03933407,0.019840516,-0.07818739,0.048664704,-0.0028463334,-0.03147536,0.13579465,-0.022999534,0.010861656,0.0013927048,0.024492247,0.029297315,0.079605676,0.03339561,-0.031342175,0.040877037,0.0077468385,0.040531147,-0.017983735,-0.019919664,-0.0021211929,-0.06396658,-0.0418273,-0.005172604,0.048654113,-0.08784706,0.027397623,0.036510084,-0.03321038,0.028673502,-0.011773853,0.00474135,0.05134083,0.048668664,0.08827462,-0.044235557,0.012176003,0.015695142,-0.043773524,0.012978952,0.010198135,-0.0020472805,0.048413977,0.002932578,0.077459656,0.005872392,0.052038703,0.011528929,-0.014452095,-0.026997266,-0.06244627,0.06960153,0.01713594,0.019020388,0.006339345,-0.029264629,0.11929304,0.027287759,0.016529825,0.07408827,-0.027273398,0.01625056,0.051936265,0.037220646,-0.04707146,-0.04633811,-0.018464895,-0.022511449,0.025634602,0.020015726,0.020411171,0.03769927,-0.02841824,-0.014610584,-0.07062221,-0.013804696,0.09288228,0.014415476,0.018426208,-0.002155731,0.03396804,-0.108159535,0.007960339,0.072130695,-3.9085855e-08,0.036134157,-0.05942601,0.048596673,0.009494379,0.06665055,0.017170496,-0.03154996,0.05041676,0.06830934,-0.050752163,0.014456733,0.071454674,0.02492987,-0.0119033735,0.025737768,-0.01270232,0.0112022245,-0.010068899,-0.003032676,0.038441006,-0.074315175,-0.032188457,-0.09192702,0.057329077,0.017710077,-0.042728815,-0.01929471,0.04616012,-0.020799687,-0.051563106,0.045071863,0.02574881,-0.011689802,0.0015566237,-0.08835737,0.039564516,0.0740011,-0.026167292,-0.054405574,0.033988476,-0.055611208,-0.0879049,-0.015793798,-0.0182794,-0.011019827,0.036632158,0.0066036363,-0.027175238,-0.020969111,-0.028119251,0.014550316,-0.036642134,-0.027513573,-0.08794858,-0.063165724,0.0032505526,0.018014183,-0.12004267,0.032044623,-0.060552347,0.029843658,0.054474927,0.2275351,0.035493445 +1.14.99.40,"The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. The other product may be barbituric acid. For a possible mechanism {misc/DMBI}. The stoichiometery of the reaction is not known.",384,0.99999994,-0.04704596,-0.00819661,-0.109389745,-0.0043169954,-0.004991809,-0.020854311,0.0027652793,0.12776412,0.04512091,0.014334047,0.024363609,-0.11067785,-0.01154689,0.08152852,-0.10051397,-0.00022475435,-0.027861906,0.038012154,-0.04586664,0.063504055,-0.042785674,0.062045135,0.088100165,-0.009042445,-0.025695225,0.034125913,0.011648368,0.068734884,0.015580424,-0.08757797,0.11806666,0.03119844,0.030636443,-0.032684173,0.07572211,-0.0019317805,0.044935934,-0.005901065,0.08863355,0.024198703,0.020924393,0.0145584075,0.027669162,-0.021535005,-0.032771036,0.06477806,-0.018579148,0.107758746,0.008338006,-0.0220436,-0.037119564,-0.02425703,-0.021694612,0.005355617,0.05806175,0.021229837,-0.029284257,0.0217528,0.017545532,0.003717991,0.03523782,0.056434296,-0.05539605,0.022393944,-0.0084997155,0.0022852377,0.01029177,-0.09116457,0.0679211,-0.015315112,-0.01941744,-0.08713301,-0.004468515,-0.073415354,-0.005040258,0.00046057443,0.059613977,-0.045171868,0.057878457,-0.0643935,-0.06619756,-0.032582182,0.027427902,-0.0042138556,-0.007266707,0.07470487,0.005229971,0.029572252,0.08358946,-0.038637202,-0.036751375,0.07171619,0.021457829,-0.03475793,-0.07925465,0.027166367,0.043850336,0.101687975,0.023167128,0.049142618,0.07712008,-0.0033411917,-0.048458457,-0.059430365,0.0072709057,-0.049756322,0.005049536,0.086114585,0.02709767,0.009832666,-0.059512418,-0.004244517,-0.03242257,0.027574712,-0.006867877,-0.01224014,0.04882591,0.015435902,-0.0024561964,-0.108697996,0.037403427,-0.05309922,-0.032194417,-2.859541e-05,-0.085257076,-0.0019299964,-0.08875578,2.3462061e-33,0.026152598,0.031582586,0.04958729,0.02699823,-0.049412858,-0.007421243,-0.09633809,-0.03808096,0.012079751,-0.03723403,-0.12707706,-0.095940344,0.023012184,-0.024744993,-0.06338791,-0.05223524,-0.07684717,-0.010059682,0.06735597,0.0006099493,0.020599531,0.10663,0.04624096,-0.03691796,0.06943997,-0.030601855,0.02648555,-0.0059328205,0.07224784,0.0005445645,-0.04608363,-0.041393943,-0.059396658,-0.031175414,-0.012537032,0.042707734,-0.04873814,0.020799043,0.001587745,0.02158413,0.02649368,-0.03024218,-0.07304468,-0.005494901,0.01761075,-0.0051826662,-0.02520247,-0.011469358,0.00041889804,-0.007026625,0.031184586,-0.043175817,0.09193718,0.012863549,-0.042816624,-0.0047514574,-0.00734698,0.03060974,0.115927,0.07559882,-0.04575092,0.08817483,-0.0057636094,0.046650294,0.04885761,-0.01647855,-0.03601745,-0.051865008,-0.0007242001,-0.042454228,-0.024920018,-0.04249992,0.10118893,0.0018595629,-0.0037132183,-0.03640555,-0.07097683,-0.08485593,0.073725164,-0.009746397,0.0025031862,-0.022628542,0.017052302,-0.03758459,-0.071765296,0.047842782,-0.054193694,-0.08398352,-0.1444221,0.039703622,0.04355883,-0.100204304,-0.023444302,-0.0055781757,0.09042175,-3.472007e-33,0.04791196,-0.064585246,-2.5450587e-05,-0.0429664,-0.006343166,-0.0061679496,-0.0012541327,-0.08655241,-0.05419241,-0.0046609924,0.12568872,-0.02448572,0.009249199,0.017771907,-0.070005074,0.044863317,0.06297674,0.043752797,0.024861092,0.011313327,0.073987536,-0.022470396,-0.053217065,0.029033825,-0.021148043,0.085972115,0.10263273,-0.04071939,0.016898284,0.01901899,-0.043876592,0.029004954,-0.056816146,-0.09644759,0.01492175,0.019174878,-0.08803583,-0.0009708204,-0.04230765,-0.034722343,-0.072108835,0.079012245,0.019710219,0.019343907,0.009510448,0.06328552,-0.016368784,-0.04839244,-0.033257786,-0.019256778,-0.0036395688,-0.012776838,-0.007802263,0.030449219,0.03024417,0.03730006,0.07999405,0.050208457,0.034294408,0.021787688,-0.029530186,0.021149078,0.03164974,-0.07830543,0.09356575,0.08110831,-0.016236845,0.06339222,0.06484556,-0.061832298,0.12338296,0.008029381,0.03626909,-0.004554826,-0.095512666,-0.05790632,-0.06442944,0.01696346,0.0347344,0.02517878,0.0431551,-0.045269735,0.07774813,0.048033584,0.0002636812,-0.111749984,0.04806386,0.064660825,-0.034532838,0.016492078,0.04468858,0.05284668,0.023772698,0.03455659,0.136077,-4.1776154e-08,0.020058796,-0.11426024,-0.017363839,-0.08209223,-0.028646482,0.030981481,-0.06948743,-0.031732757,0.08909449,-0.08858965,0.025969435,0.05307298,0.03726275,0.0442084,-0.029674435,0.016757198,-0.07353946,-0.013220763,0.005802772,-0.04905353,-0.03676678,-0.0029540332,-0.012061334,-0.052511927,-0.021970015,-0.06614719,-0.02159187,0.07053633,0.035167653,-0.07455035,-0.012079724,0.0038342562,0.0004890068,-0.06060434,0.06242939,0.029609326,0.005475847,-0.0464044,-0.073363125,0.02085792,-0.0025710592,-0.036096346,-0.020611461,0.044882543,-0.002774394,0.007619064,-0.029250238,0.1052215,-0.03332897,-0.027379904,0.004522312,0.097820014,-0.044418037,-0.044776313,-0.0606636,0.04692612,-0.097451605,0.0049101044,-0.021818062,-0.011638585,-0.010891603,0.027814,0.008839512,0.025825165 +1.20.4.3,Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. The substrate arseno-mycothiol is formed by EC 2.8.4.2 (arsenate:mycothiol transferase). A second mycothiol recycles mycoredoxin and forms mycothione. ,384,1.0,0.09306414,0.020261712,0.0027701505,0.008550769,0.1534787,-0.020247951,0.07894085,0.073416285,0.06823289,0.0142320385,0.040542316,-0.025049565,0.05512896,0.005361857,-0.10481153,-0.05022215,-0.08514225,0.07230744,-0.006605437,-0.027031364,0.0012599295,0.019822361,0.016469259,-0.02849149,-0.047343817,0.048307054,0.036034588,0.0016398763,-0.06210269,-0.09137588,-0.058238085,-0.050495867,0.019959955,-0.046224713,-0.08187979,0.0843766,-0.08820834,0.00397802,-0.010092274,-0.086914,0.009927567,-0.045555506,-0.021877818,-0.033556588,-0.048722614,0.035915613,0.0023266023,-0.042220302,-0.020863948,-0.01830357,-0.03338314,0.055950046,-0.055259533,0.058896467,0.06730464,0.036099304,-0.022918863,0.012405027,-0.05231918,0.10163438,0.06636389,0.039345704,-0.069506206,-0.038481157,0.04023149,-0.049927473,0.06775006,0.037254307,-0.039192714,-0.028259097,0.063258715,-0.03317149,-0.021241754,0.0036174015,0.06118339,0.07827806,0.026123945,-0.0431059,0.041491624,-0.020579822,-0.020697635,0.04411773,0.123635866,0.013940985,-0.00802427,-0.04966308,0.0040148264,-0.07698041,0.015497078,0.067038,0.1276036,0.049484216,0.033398762,0.01147152,0.012452098,0.03311971,0.06546,0.073606126,0.012051919,-0.01726765,-0.006387977,0.013559448,-0.18069431,-0.058943488,-0.0028677608,-0.05773919,0.020462587,0.004154936,-0.017233457,0.03535579,0.039076187,-0.04936704,-0.043720398,0.014473323,0.03847862,0.09058931,0.07012552,-0.010750276,-0.060051955,0.01576145,-0.0075040334,0.057740986,0.016300043,0.011956639,-0.073645286,-0.03277183,-0.07038883,3.8936417e-33,-0.007408869,0.12071672,-0.11146235,-0.013501892,0.031279787,-0.09350837,-0.11877999,0.050423168,0.01735946,-0.059338283,-0.052807525,-0.08693045,-0.061899535,-0.0010254362,-0.053157903,-0.0829794,-0.04423574,-0.009287552,0.07879286,0.008710626,-0.039538696,0.0091459695,-0.013292226,0.002162754,-0.0012370695,0.025688045,-0.01366375,-0.021059047,-0.043640662,0.0010776711,-0.010170752,-0.026844483,-0.11861929,-0.032456025,0.04918897,-0.008726608,-0.029532842,-0.011240847,-0.061002117,0.008707125,-0.019521503,0.026870124,0.017233785,-0.019066408,0.06320584,-0.10997737,-0.074907914,0.055839945,0.052833613,-0.031328235,0.043692935,-0.044716325,0.124392405,-0.07448614,-0.060673457,-0.019388018,-0.038039926,-0.033007536,0.006091283,0.086443834,0.05760579,-0.0018330398,-0.050668202,0.102034755,0.01813095,0.04106064,-0.073367305,-0.05252204,0.015323819,-0.03581759,-0.031480342,3.4947974e-05,0.08008002,0.019073328,0.00810113,-0.008687461,-0.11159541,0.038757227,0.0043328097,-0.027118042,-0.028050024,0.018067274,-0.014745897,-0.014796322,0.030888623,0.0011412037,0.009744796,0.010579726,0.052578732,-0.0065768687,0.016233796,-0.094186775,-0.08082963,0.045003355,-0.001579635,-4.5005157e-33,0.035830908,-0.060076088,0.070027255,-0.049522504,-0.07054494,0.03842714,0.028883133,0.073609956,0.019755801,0.058007374,0.052083556,-0.034472816,0.049355753,-0.04639898,-0.058270562,-0.068768635,0.017270036,-0.0024610928,0.01811745,-0.052544188,-0.060952872,0.06471342,0.0045056264,0.013399461,0.0029508893,-0.013817047,-0.04061337,0.035591643,0.11905215,0.02418177,0.009164109,-0.003167398,-0.00903853,-0.04900172,-0.037482124,0.046512146,0.0042684143,9.52846e-05,-0.037782036,-0.015351708,0.023776123,0.049044434,0.008294895,0.09355935,0.05083926,0.0316965,-0.06494894,0.081895106,0.070763,-0.047515433,0.030338034,-0.036027588,0.028980168,-0.020282404,0.043291926,-0.036247082,0.104240775,-0.021600965,0.034211688,0.023781767,-0.04926836,-0.020591805,-0.012099088,-0.04631791,0.09814751,0.04127304,-0.051929884,0.096020065,0.051693942,-0.039355166,0.053076446,0.011820285,0.02578043,-0.05401753,-0.030668098,-0.031712156,-0.0005742954,0.031921018,0.028739527,0.019140672,0.076470844,0.042384416,0.0005962944,-0.076682575,0.011742934,-0.07035678,0.040521715,0.13850965,-0.102989346,0.036908504,0.0038757052,-0.015893236,-0.044540107,0.026002608,-0.029674936,-3.7725492e-08,0.06211842,0.0073976805,0.055507205,-0.05203197,0.011822027,-0.025886454,-0.00649985,0.004806364,0.08017987,-0.08660107,-0.04853596,0.061421134,0.071107276,0.01686068,0.034923118,0.0068473257,0.018029945,0.029734727,-0.013467474,-0.019191796,-0.06892369,-0.07408919,-0.033532,-0.04371354,0.027163286,-0.040313426,0.027585354,-0.023917316,-0.037013732,-0.03746374,0.0032903727,0.021711536,0.047575127,0.028543608,-0.07318808,0.06002289,0.00013513524,-0.10949431,0.02042463,-0.015329621,-0.027602492,-0.067385204,-0.038746476,0.023689842,0.04119251,-0.0036658258,-0.049623225,0.0007565795,-0.0038225083,-0.052284487,0.012751399,-0.011847808,0.0875486,-0.062361278,-0.04638975,0.0151365595,0.047716774,-0.0023256121,0.09015269,-0.03231188,0.01890428,-0.0005937942,0.104149275,-0.035495378 +1.22.1.1,The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.,384,1.0,-0.04732591,-0.124504685,-0.13080528,0.012236849,0.008630884,0.0054645604,-0.0051550474,0.05032982,0.01258118,-0.04408672,0.016587343,0.008670598,-0.09522941,0.062230792,-0.036362212,0.036162514,-0.056723572,0.008924196,-0.08422513,-0.06399267,0.08566975,-0.027401645,-0.0012054865,-0.017053876,0.019110646,-0.009315655,0.05357547,-0.058445193,-0.018672291,-0.041656848,0.005009969,0.029316802,0.019383648,0.0053720945,-0.0057108635,0.06194932,-0.0837086,-0.09699803,0.01277199,-0.066257864,0.08289319,-0.013513658,-0.04652264,-0.08613505,0.023363357,-0.041206755,-0.06694482,0.037298683,0.09532823,0.045061972,-0.031589888,-0.025344035,-0.05367081,0.067953475,-0.009821925,0.038635995,-0.036835365,-0.008675023,-0.06398179,0.091243885,-0.032137733,0.03916018,0.06395741,-0.018521138,0.10939172,-0.038982835,-0.007991787,0.0065222387,0.029134376,0.023527121,0.016964665,-0.07107389,-0.07247183,0.015850982,0.05114155,0.027518405,-0.015235366,0.05091292,0.0004385727,-0.05707985,0.07334022,-0.0228999,0.11974293,0.1409962,0.0051992596,-0.02410344,-0.049136963,0.0011269319,0.01611871,0.13262266,0.025338942,0.04252839,-0.034700695,0.020072082,-0.0252159,0.06607566,-0.027195862,-0.0014325271,-0.0973068,-0.007613255,-0.015767515,0.026988482,0.024968632,0.003883468,-0.027073793,0.019386591,0.009686305,0.013646773,-0.021015815,-0.06638252,0.009464777,-0.03786092,0.08906541,-0.07780677,-0.014972872,0.07624693,-0.031609956,-0.025619384,0.016482169,0.049422424,-0.01443264,0.077555194,0.0704611,0.09891898,-0.010543783,0.087080136,-0.12387516,7.357271e-34,0.04495285,-0.0009349606,-0.0057260315,0.00795318,-0.040225714,-0.021078039,0.0044400506,0.06608324,-0.013071178,-0.03646838,-0.02440845,-0.048029788,0.074401796,-0.04716762,0.03492394,-0.06538772,0.042968467,-0.010471943,0.04084941,0.0066054803,0.08158944,-0.024063738,-0.042113364,0.005176567,0.07211759,-0.010117646,-0.05010809,0.0015320936,0.04398715,0.027853547,-0.011111267,-0.105932556,-0.07173677,0.012218068,0.061720975,0.021847762,-0.011489848,-0.02497645,-0.0962755,0.11182546,0.036614124,-0.051128913,-0.0560935,-0.058524694,0.036923196,0.02540435,-0.06753672,0.08151361,-0.041128118,0.09625028,0.0632718,-0.024616681,0.10754963,0.022236884,0.007847479,0.03313687,0.017040778,0.017580649,0.065401055,-0.048022673,-0.041809138,0.04743523,-0.07470988,0.053861625,0.02677929,0.040896144,-0.088950306,-0.042148698,-0.006355175,0.071402065,-0.08174438,-0.01486712,0.064418174,0.057123575,0.05522541,0.0041516176,-0.12037989,-0.021471065,0.004199134,0.034011923,0.00084302924,0.003697576,-0.012111436,-0.009609609,-0.03587448,0.00087054475,0.0046822224,-0.07064121,-0.04594386,0.0017002056,0.113994665,0.018141538,-0.027026532,0.009510066,-0.015998978,-1.2329163e-33,0.023980716,-0.121421635,-0.03969027,0.008280182,-0.051245917,0.03418275,-0.013465003,-0.054021336,0.060559556,0.0066247964,0.07592894,-0.035633992,-0.034524582,-0.06039042,-0.02399215,0.057334166,-0.040699586,0.091789715,0.06124271,0.005789404,-0.064595394,0.06847982,0.047441524,0.09446708,0.017594265,-0.0112414155,0.07190003,0.03771111,0.06277522,0.0493776,-0.041184716,0.01919019,-0.017351221,-0.04058105,-0.00943532,0.05458068,-0.029667616,-0.027333423,0.057737973,0.019835498,-0.016191246,0.04829091,0.029010033,0.057255395,0.015952991,0.06993282,-0.052244034,0.058347095,0.047831614,-0.021464992,0.011157962,-0.027436996,-0.017237408,0.08072806,0.0042439336,-0.008673079,0.09026342,0.04169169,0.014088466,-0.0011875733,-0.011343964,-0.089696795,0.03108624,-0.06064201,0.046624456,0.08581329,0.033323526,0.0950128,0.026669089,-0.08343547,0.07504327,-0.06846572,0.012674956,0.03639515,0.0050265864,-0.0022688296,-0.048513755,0.034900825,-0.037540752,-0.057354204,-0.032831863,-0.023858977,-0.026521642,-0.09090983,0.0078110136,-0.07796149,-0.009881943,0.06302169,-0.008938594,0.0014708658,-0.007892221,-0.03722477,-0.07214994,-0.019027399,0.024173047,-2.9867106e-08,0.028925207,-0.048269406,0.028482664,-0.016644694,0.0809407,0.040152375,0.014656962,-0.026948795,-0.03465013,-0.019918144,-0.07074093,0.05983612,-0.07948656,0.045025516,0.06931958,-0.04312898,0.008787301,0.030599816,-0.030981805,-0.07367227,-0.05218534,-0.013722578,-0.10911339,-0.008491703,-0.0063601183,-0.03729538,0.007402415,-0.022302918,0.084800325,-0.054108996,-0.034553587,0.05919369,0.050188825,-0.011846962,-0.13964301,-0.0355544,-0.0060326075,-0.034662947,-0.04417662,0.06877404,-0.040234905,-0.011316543,-0.052749813,-0.044389732,-0.008072343,-0.022882992,0.10132435,0.01337174,-0.041230623,-0.02760628,-0.0063467827,-0.0019604692,-0.016042061,0.036415093,-0.017915437,0.023214879,0.024566982,-0.04422262,-0.032877505,-0.06932111,-0.021431861,0.035635665,0.11717955,-0.030535076 +2.3.1.190,"Requires thiamine diphosphate. It belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.104, pyruvate dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, and EC 1.4.1.27, glycine cleavage system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). ",384,1.0,-0.051674336,-0.0406303,-0.07027964,-0.13543078,0.07897043,-0.045112308,-0.10958946,0.027097711,0.0056175482,0.011770716,0.036217634,-0.04204004,-0.019264825,0.011822511,0.020352632,-0.044964824,-0.06905581,-0.031605132,0.020895282,-0.031175002,0.020225333,0.09645681,-0.008554698,-0.018219145,-0.03286376,0.049119737,0.07307414,0.008565339,-0.058506105,-0.1191863,0.0013100479,-0.09484891,0.04416661,-0.06813839,-0.019930298,0.10270433,-0.040073402,0.0069773667,0.0050275666,0.0549617,0.029759852,0.045628056,-0.0053629726,-0.009338619,-0.015383784,-0.018900394,0.018175041,0.057344213,-0.015043889,-0.00037906112,-0.034973178,-0.014656216,0.0023855509,0.071571894,0.05909914,-0.052420806,-0.08249024,0.07379911,-0.07616736,-0.0059566144,-0.050492123,-7.664798e-05,-0.026768481,-0.042013336,0.06709181,-0.017325422,0.08592813,-0.09067922,-0.036643215,-0.0057261563,-0.102417186,-0.031101083,0.069684,0.014778593,-0.07432037,0.13168149,-0.024745828,0.010181494,0.022211488,-0.06177421,0.020637412,0.0034776027,0.039970662,0.029212149,0.010517829,-0.019941922,-0.045179363,-0.014645702,-0.004255747,0.021566363,0.04023572,-0.019777175,0.043549042,-0.022683928,0.04963823,0.0822835,0.0590389,0.03473242,0.0016250837,-0.054852363,-0.005747251,0.09260157,-0.011616275,0.0025746145,-0.058640942,0.0067194556,-0.034537077,0.09671364,-0.026333874,-0.008715651,-0.003617903,-0.017261362,-0.014809665,0.006123041,0.0014211223,0.07758925,0.071201,-0.015662026,0.014972425,-0.03056455,0.066087626,-0.009031527,0.12920563,0.08518351,-0.036704496,0.04030247,-0.12821165,4.5340907e-33,0.042660337,0.04241264,-0.033209577,0.010414817,-0.04119349,0.028230853,-0.11383496,0.08225499,-0.01392899,-0.012696481,-0.09070665,-0.020957166,0.11303484,-0.006893294,-0.026270252,-0.03940436,0.00076279894,-0.02309319,0.06124889,-0.02336092,0.004193859,0.057639237,-0.01403075,0.032441508,0.005367938,0.041666914,0.023652999,0.044940583,-0.060641244,-0.01549865,0.031423777,-0.13563584,-0.0750307,-0.0031314807,0.009924542,-0.043101475,-0.044616736,-0.018939726,0.02450299,0.00025847825,0.030989999,-0.019487789,0.02724795,-0.01115201,0.0034243823,-0.047925666,0.007450522,0.046120968,-0.002979375,0.032259755,0.043688986,-0.024299413,0.08593708,-0.07261073,-0.081309594,0.0013708868,-0.03092289,0.005851912,0.06667755,0.0986493,-0.03543849,0.040211797,-0.0067001414,0.027584417,-0.0056660534,0.004619421,-0.14766157,-0.054976672,-0.012512701,0.046294317,0.008078406,-0.057816118,0.14569287,-0.015778933,0.0139169935,-0.03323192,-0.013827801,0.05054399,-0.022475904,0.016522856,0.016086427,0.044994097,-0.0042047002,-0.009697739,-0.044190586,-0.02196315,0.0205246,-0.07132084,-0.028156472,0.036278002,0.007079982,-0.041244905,-0.02074435,-0.026617913,0.10512515,-4.757936e-33,0.09640455,-0.051986776,0.06421931,-0.117288835,-0.0043245787,0.054748658,0.057297714,-0.04832156,0.018309176,-0.058792975,0.07218718,0.019293757,-0.0062938696,-0.05540786,0.0086063165,0.0606054,-0.05127421,0.032290306,0.049264893,-0.03403814,0.024952715,0.08733454,0.00127808,-0.004374024,0.06880718,0.05709285,-0.01951081,0.016096609,0.049016602,0.056476567,-0.08708333,0.042785246,-0.01755338,0.052980535,-0.07485001,0.03537268,-0.07568474,-0.053937934,-0.008742017,0.013356398,-0.0025850362,0.05480573,0.019538827,0.037536733,0.076490305,0.072205134,0.012155737,0.028893806,-0.04883339,-0.014494451,0.0060746977,-0.013308283,-0.061152108,0.05388646,0.07723291,0.057962853,0.050878998,0.043434527,0.048928753,-0.038103696,0.011729148,-0.08357394,0.036002733,0.0058973194,0.035786234,-0.07414745,0.016755925,0.03497543,0.08501396,0.061871536,0.0023922715,-0.040164787,0.039907716,-0.020650344,0.011513725,0.05234721,-0.06609374,-0.0005033445,-0.01043615,-0.0701771,-0.01543109,-0.035302557,-0.0315225,-0.03041104,0.042763866,-0.034156162,0.023185914,0.090335265,-0.0064399694,0.012688018,-0.0063225753,-0.03664102,-0.012064875,0.15089859,0.101661384,-4.947919e-08,0.059975076,-0.060507674,0.02047012,-0.018647758,0.045803662,0.036996786,0.019391982,0.10256998,0.060015354,-0.06881346,0.029279042,0.0458646,0.01907282,0.021269657,0.023399975,0.001834768,-0.072275095,0.06943564,-0.03685945,0.013418818,-0.06727756,-0.06031034,-0.11609726,0.00917911,-0.010061548,-0.059899326,-0.044810303,-0.049925167,-0.0036989523,-0.03426781,-0.0039108815,-0.006543218,0.016572654,-0.107888184,-0.035953976,0.014884048,-0.0062202206,-0.010934417,-0.041146625,0.025033642,-0.0227731,-0.0835519,-0.07235134,0.06681654,0.055538457,0.022832414,-0.039190773,0.062563024,-0.07104264,-0.029849859,-0.030647947,-0.0011422243,0.007777165,-0.06718176,-0.081875,-0.014387187,-0.047570664,-0.055185854,0.037130065,-0.04360364,0.012743448,0.07459698,0.11863495,-0.033112247 +2.5.1.77,"Binds a [4Fe-4S] cluster. The cluster is coordinated by 3 cysteines and an exchangeable AdoMet molecule. The first stage of catalysis is reduction of the 2 AdoMet to produce 2 methionine and 2 5'-deoxyadenosin-5-yl radicals that extract a hydrogen from each of the substrates permitting the condensation of the two [1]. The overall reaction catalysed is the transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylaminopyrimidine-2,4(1H,3H)-dione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO). 7,8-Didemethyl-8-hydroxy-5-deazariboflavin is the chromophore of the hydride carrier coenzyme F420 [1].",384,0.99999994,-0.020786561,-0.054921046,-0.08883433,0.051737145,0.0980073,0.037433293,-0.050436534,0.06416686,0.0034317044,-0.025463892,0.004906074,-0.012996209,-0.012073476,0.032102305,-0.030510863,0.07792692,-0.06482097,-0.00046194735,-0.02276955,-0.055723935,-0.011220977,-0.018444251,0.023879046,-0.0066576586,-0.015599576,0.07022613,0.045114845,0.001234126,-0.05355909,-0.052240398,0.03969875,-0.039826863,0.026537402,0.0011369473,0.008611452,0.13738698,-0.007588954,-0.029693525,0.055568956,0.005366125,-0.008802227,-0.005438625,-0.034395337,0.02050851,-0.048925705,-0.04681193,-0.038992926,0.056845024,0.045167137,-0.05097962,-0.043449987,0.09289362,-0.03398467,0.05479784,-0.017457455,0.04156238,0.03660921,0.02275895,0.027046558,-0.0006278129,0.04373096,-0.034207344,-0.00020461704,-0.020417938,-0.07257691,-0.016955523,0.08337781,-0.016587231,0.07483431,-0.012656958,-0.02295805,0.030610625,-0.0025585028,-0.035883438,0.010637193,0.008162008,-0.006730198,-0.060397863,0.07705863,-0.04344712,0.008724876,-0.030986568,0.07636713,0.0975497,0.040595192,0.005239126,-0.052741263,-0.051729023,0.052423634,-0.018799253,-0.055998195,0.02834817,-0.055870283,-0.04647314,-0.098203026,0.033524398,0.07997298,0.0019657137,0.07423892,0.06294248,-0.025964895,0.019731667,-0.1032461,-0.08144243,-0.041570105,-0.030655667,0.040318914,0.07708388,0.024454162,0.01716802,0.011560514,0.004355933,0.023159022,0.023674743,-0.04026633,0.10345326,0.048307836,-0.032771442,-0.05743463,-0.025085147,0.038685266,0.043407917,0.11107936,0.055663027,-0.056815915,-0.004929502,-0.16145307,4.0776573e-33,0.071383156,0.019582057,0.0449629,0.058144175,-0.0033594433,-0.033735495,-0.12972294,0.060064286,0.011233673,-0.01086809,-0.074850775,-0.062137783,0.09219153,-0.049699686,-0.061134342,-0.13250604,-0.027626408,0.024259865,0.03386652,-0.014290517,-0.03875821,0.07839266,-0.042419426,0.056856412,-0.028920308,0.032739274,-0.030397512,0.029574556,0.08669417,0.026027882,-0.11609708,-0.052494075,-0.075080596,-0.032357067,0.0015706354,-0.0077846935,-0.1036221,-0.07499381,0.027344882,-0.0013185472,0.0072595165,-0.015129353,-0.017190175,-0.07837171,0.08773141,0.015196013,-0.005934683,0.031499624,-0.013005972,0.062473826,0.021235514,-0.09666375,0.108756505,-0.011834017,-0.08993634,-0.03792109,-0.008158383,-0.0484528,0.08367792,0.10706078,-0.015818879,0.0010057146,-0.06113863,0.0066651083,-0.0014585705,-0.016458929,-0.0019971007,-0.006499104,-0.023027621,0.059065953,0.023926916,0.08191585,0.12092464,0.07343835,0.036324874,0.024483819,0.009057175,0.025192732,0.03780364,0.004848973,-0.031548917,-0.009861273,-0.0074761254,-0.013209543,-0.036572073,0.005229726,0.026179748,-0.049193032,-0.033164207,0.042576913,-0.023223143,-0.08214853,0.022813583,-0.022302043,0.016853722,-4.9086796e-33,0.055237047,-0.045745272,-0.02280446,-0.085420564,-0.029030042,0.05971773,0.037628613,-0.0067586293,-0.003953236,-0.018097283,0.13013865,-0.025681533,0.028460752,-0.052580964,0.018449659,0.044639725,-0.00051800703,0.039116897,0.015550107,0.012848032,0.050741702,0.020695793,0.003268901,0.06754555,0.071781226,0.027147701,0.068859085,-0.013794517,0.041266244,0.15113239,0.015372964,-0.05496824,-0.038151238,0.057013623,0.025679749,0.08396587,-0.095554315,-0.0122730415,-0.025833223,-0.016018905,-0.036707778,0.0024497793,-0.028279686,0.08254857,0.018837325,0.07627724,-0.010536114,0.03137599,-0.0026207243,-0.030840673,0.008354489,-0.04501629,-0.10711907,-0.011001602,-0.07711008,0.07507852,0.020692352,-0.0051160716,0.013022489,0.0007289791,-0.04047834,-0.08083741,0.024572212,0.027155656,0.020141577,0.024664465,0.004916204,0.027508354,0.020683907,-0.033837143,-0.030334653,-0.01114823,0.07250481,0.0678946,0.0276775,-0.034062028,-0.013906254,-0.060698207,-0.042475045,0.012724806,-0.015686663,-0.00083679555,-0.04288982,-0.07910485,-0.01999073,-0.12767716,0.017348433,0.1027416,0.015979908,0.031215735,-0.033711467,0.060426194,-0.020508407,0.016606677,0.059826575,-5.1805646e-08,0.04496665,-0.037873283,0.0854584,-0.04635883,-0.022799347,0.009764095,-0.027273955,-0.00632301,0.011349921,-0.02809238,0.043707713,0.069252335,-0.042032097,-0.004748309,-0.03959087,0.007240829,-0.06366701,-0.020413458,-0.036991067,-0.009687011,-0.066354044,-0.036361963,-0.09140432,0.00035354312,-0.01846529,-0.11412674,-0.0016703645,-0.034416135,0.014048605,-0.12201255,0.076425076,0.04928652,-0.04987244,0.027493143,-0.07174669,0.023169963,-0.06823985,-0.00063453795,-0.03170446,0.076034985,-0.022061024,-0.028590579,-0.08177717,0.059937827,0.017362788,0.007015949,-0.024334716,0.055101912,-0.0064658048,0.022185473,0.0009412765,-0.0043465765,0.019958211,-0.03972541,-0.09619262,-0.009108512,-0.08848886,0.008832176,0.024750499,-0.059446618,-0.0768033,0.038873564,0.14799652,-0.026504785 +2.5.1.78,Involved in riboflavin biosynthesis.,384,0.99999994,0.017172929,-0.030575434,-0.15535693,0.018633043,0.003057954,0.09059171,-0.096712515,0.057179254,0.055255104,-0.012710508,-0.04172239,-0.0057472354,-0.054047566,0.0103619825,-0.07782236,0.0056522517,-0.076320335,0.041353464,-0.033439744,-0.044404443,-0.012681012,0.06327659,0.021653207,-0.0006414693,0.050034262,-0.033351637,-0.030111982,-0.027691135,0.047623977,0.022448659,-0.024678933,-0.007826298,0.06429399,-0.048935335,0.011982302,0.08206872,0.0011025469,-0.071332134,0.040161982,0.0092599895,0.01600456,-0.00015117618,-0.056013893,0.016028287,0.026598554,0.008794214,-0.0496329,0.09842675,0.018356971,0.047242,-0.07953936,-0.013950425,-0.027760293,-0.09141549,0.10382916,-0.014130014,0.04366031,-0.05839514,0.05621639,0.014230591,-0.011997832,-0.09168855,-0.009002447,0.025986126,0.011098411,-0.061629932,0.06825837,0.02803792,0.01315062,-0.04800863,0.01983301,-0.061193433,-0.046649314,0.04171202,-0.067453586,0.032928787,-0.021549214,-0.013894808,-0.036153477,-0.015531284,0.07740804,0.0063674506,0.0019608333,0.032342408,-0.015155468,0.026961364,-0.0010029844,0.05067365,-0.015783845,0.09109567,0.026508022,-0.020300793,0.05560653,-0.053130507,-0.013848862,0.033957288,0.06732106,-0.011429478,-0.0033669844,-0.033106953,-0.009718071,0.024715204,-0.01726488,-0.040548887,-0.0037426653,0.027843466,-0.04566926,0.063918665,-0.054047763,0.011215789,0.05743741,0.012344625,-0.050783042,-0.022985842,-0.005073282,0.059048727,0.07922762,-0.00084450044,-0.068048425,0.051051103,-0.007613848,0.024125094,0.03852926,0.068442196,-0.07558558,-0.06698898,-0.015426404,-1.5108605e-33,0.094629735,-0.020881867,-0.044922315,0.00304006,0.014124439,0.011854552,-0.118330605,0.008096673,0.055347264,0.032938305,-0.09466489,-0.09752978,0.063489065,-0.09112345,-0.0021033972,-0.04912591,-0.012971473,-0.053568315,0.00489531,0.03207714,-0.03984438,0.08433351,-0.017780816,0.08723276,-0.0073089194,0.05441836,0.018219855,-0.035502814,-0.00027918108,-0.0478857,0.0122439265,-0.055853773,-0.0407713,0.012394114,0.04382916,-0.044186756,-0.025465315,-0.05172554,0.015360556,0.07196973,0.08570729,-0.052903168,-0.045199446,-0.026310055,0.060690094,0.017435864,-0.02382419,0.024350967,-0.012117885,0.01695709,0.058052387,0.019342052,0.071889564,-0.028714215,-0.04182043,-0.0037101503,0.004554768,-0.022449827,0.07878288,0.06036017,-0.025234966,-0.026653783,0.018282343,0.0004117345,-0.056255136,-0.048369855,-0.08546767,-0.09911613,-0.05202175,-0.044617817,0.030294878,-0.09151358,0.0623097,-0.03002947,0.010363628,0.036318965,-0.053639337,0.023998357,-0.011101347,-0.0045238486,-0.026850335,0.10895393,-0.0033903844,0.0012986704,-0.030391779,0.010360436,-0.030111963,-0.09713615,-0.004096302,-0.03068922,-0.0055289282,-0.023983622,-0.033423744,0.0020490887,0.06904899,-1.912839e-33,0.08435304,-0.12466108,0.06494464,-0.05675202,-0.039688237,0.07204685,-0.066039845,-0.047630243,-0.04321309,0.017458277,0.036408737,-0.0044421665,0.014746233,0.0030313302,-0.056301124,0.07016121,0.061533533,0.06327791,-0.09480985,-0.013315547,-0.04608773,0.041971575,0.044696286,0.03368326,0.020988682,0.07627442,0.019910023,-0.061331518,-0.017311405,0.107368514,-0.026409259,-0.029230835,-0.08784247,-0.007098516,0.024949862,0.10361479,0.00094262377,0.06519814,-0.032934446,0.026576918,-0.10208412,0.09328103,0.021765238,0.039874837,0.054927524,-0.0037336454,0.024161573,-0.07010091,-0.029523725,-0.05353773,0.07444347,0.05037885,0.026809119,0.055684466,-0.019253353,0.0091268085,0.06560827,-0.02019715,0.08752959,0.01664756,-0.015282635,-0.06532584,0.021703579,-0.0012080355,0.036242474,0.07049926,-0.031733036,-0.005744808,0.06904724,-0.09685007,0.03451428,0.013812144,0.06525603,0.088806726,0.006449531,0.0047392123,-0.03896748,-0.078516506,-0.06959003,-0.030720513,-0.0791498,0.021764,-0.034560747,-0.006546519,-0.07783081,-0.14672725,0.04733471,0.056898583,-0.029008033,0.01031889,-0.0032762121,0.059221357,-0.029863171,0.05932236,0.095452465,-1.7849402e-08,-0.004889119,0.012753184,0.02458535,-0.04941937,0.048040874,-0.03872265,-0.019756945,-0.022012755,0.04468289,-0.041604176,-0.086782224,0.051834315,-0.029511426,0.01967755,0.067828156,0.06153159,-0.07213897,-0.039891183,0.005775035,0.0140646985,0.046392947,0.002646892,-0.059798833,0.007953724,-0.078448586,-0.091823556,-0.043197438,-0.0033947262,0.10248327,-0.015596179,0.06268439,0.08304512,0.012514395,-0.107487746,-0.07011899,0.013375777,0.09851304,-0.0554891,0.021830304,-0.029714584,-0.106115475,-0.056117594,-0.051234446,0.040129527,-0.03836753,-0.022130143,-0.005239515,0.084769644,0.012386288,-0.0010037438,0.08936744,0.04679484,0.01362322,-0.02389769,-0.057968438,-0.027262608,0.0010311501,-0.056889966,0.047556356,0.0026993724,-0.08343937,-0.0376315,0.12849459,-0.049870413 +2.5.1.79,This plant enzyme is crucial for the proper functioning of xylem vessel elements in the vascular tissues of plants [3]. 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+2.5.1.80,"This enzyme is more flexible towards the aromatic substrate than EC 2.5.1.34 (4-dimethylallyltryptophan synthase), but similar to that enzyme, accepts only prenyl diphosphate as the prenyl donor.",384,1.0,-0.0685713,-0.010944347,-0.02251363,-0.04745716,0.112111464,0.004491241,-0.04403192,0.06319786,0.03899747,-0.019351732,0.015547483,-0.048306502,-0.0860342,0.025833813,0.021960897,0.015583291,0.042403005,-0.03317057,-0.027108504,-0.023132216,0.027607942,-0.03703078,-0.0145765925,-0.020003587,0.052491,-0.010841813,0.041501768,0.025543762,0.027917322,-0.10739366,-0.029081436,-0.01982542,-0.06474922,-0.065418795,-0.014491473,0.0904856,-0.033068877,-0.07846824,-0.007749793,0.06654307,0.07774233,-0.020910041,-0.03972743,-0.0272564,-0.06692934,-0.05337777,0.037116025,0.022861155,-0.0027159501,-0.106577136,-0.036489956,-0.05275743,-0.0013498592,-0.02417245,-0.03064042,0.032965038,-0.108215705,0.035973977,-0.0655838,0.011400415,0.019762311,0.02448598,0.041981183,-0.033522155,0.04571174,-0.045458518,0.09606083,-0.14082585,0.050587192,-0.03699714,-0.08868523,-0.04664295,0.023809345,0.091097265,0.054569554,-0.021777065,-0.042662457,0.002228025,0.07650523,-0.020206245,-0.015211627,-0.03343202,-0.0750368,-0.024318863,0.03209214,0.035291526,0.010740737,0.028925821,0.034626324,-0.0145876855,0.09305939,-0.02398473,-0.016582036,-0.0073317545,-0.06645962,0.041843608,-0.039181653,0.075163424,-0.0022450448,-0.021454936,0.054461457,0.12379967,-0.08041278,-0.06588648,-0.010654589,-0.047729477,0.0763132,0.039097328,0.019437384,-0.0021590388,0.022502925,-0.033692826,0.055538617,-0.016397951,-0.03843661,0.06730678,-0.074137315,-0.061236765,0.013903595,0.021956017,0.042333942,-0.008462249,0.05231823,0.12675999,-0.03060844,0.04415847,-0.14326943,2.2209632e-33,0.034352202,0.0704235,0.08560875,-0.023698175,-0.078105174,0.048019137,-0.09522532,0.026572915,-0.08734486,-0.07178377,-0.07184707,-0.06853274,0.05443536,0.014875357,-0.01627606,-0.06743525,-0.054244824,0.06283775,0.055453118,-0.004968238,0.01833275,0.0112732565,-0.061902314,0.037028875,0.048793036,-0.01464177,-0.03876302,0.03165408,0.072465695,0.027911408,-0.03532816,-0.07717792,-0.060904503,-0.030244753,-0.04258469,-0.038597763,0.009037101,-0.040515862,-0.011330812,-0.013232953,-0.038283546,0.031121608,0.10383831,0.0051477365,0.043546338,-0.03239454,-0.07622224,0.05837017,0.012526764,-0.03569963,-0.010628645,-0.044934005,0.11392715,-0.032287996,-0.011525081,0.018368388,0.011752068,0.026294667,0.030469256,0.06476448,-0.05091933,0.07646814,-0.09295282,-0.021180823,0.013319555,0.040307887,-0.0133600775,-0.025640449,0.011273416,0.12222026,-0.04717521,0.02354779,0.044816375,0.035715908,0.021997774,-0.08072425,-0.020868642,0.005436926,0.07300712,0.042711966,-0.04562419,-0.029159036,0.017109795,-0.03667055,-0.07848476,-0.027968336,0.031558197,-0.024452617,0.06774431,0.0910181,0.05901241,-0.049005363,-0.013755474,-0.005202955,-0.020043375,-3.0852025e-33,0.09708796,-0.067827694,0.0021569633,-0.0061672986,-0.0047309604,0.041814182,0.08548515,-0.0035885635,0.05761186,-0.027054094,0.1121609,-0.05540095,0.060468376,-0.059002604,0.03447873,0.009930047,-0.13354415,0.04596908,0.0790717,0.048120238,-0.0041851085,0.027378174,0.011072208,0.08389787,0.041655622,0.0026491384,-0.04250672,0.06472161,0.014609619,0.029857745,-0.06620783,-0.025576891,-0.06633564,-0.019962916,-0.068895444,0.03343483,-0.05603088,0.026430681,0.022152841,0.010459894,-0.03721597,0.038182523,0.024801752,0.024958024,-0.00868608,0.08951781,0.003202864,0.03688738,0.017032648,-0.06032038,-0.044970155,0.05953178,-0.012188271,0.03831778,0.036261708,0.021658573,-0.020503975,0.03198361,-0.035565153,-0.0028721434,-0.06356681,-0.052448664,0.083273284,-0.051024873,0.048104048,0.034702256,-0.03052946,0.086877935,0.0074774306,0.0076323915,0.048949987,-0.05035914,0.01186133,0.025844032,-0.028816108,-0.034631725,-0.0043858206,0.007129517,0.028572131,-0.035996903,0.020961706,0.015192386,-0.05090129,-0.08025349,-0.017848043,0.0064696004,0.08488315,0.08019134,0.004296656,0.07514108,-0.038061306,0.020691818,-0.022329055,0.05514159,0.06546696,-3.4432748e-08,0.028862944,-0.04910206,0.07575691,-0.032411788,0.0419162,0.02220015,-0.01487112,-0.009257785,0.04213803,0.031714734,-0.07836827,0.045118634,0.033765726,0.024108225,0.014262655,-0.022972153,-0.06014211,0.051388845,-0.00030878463,-0.028000353,-0.03569005,-0.00469877,-0.10681961,-0.049710725,0.035459433,-0.035936553,0.0012319899,0.084906794,-0.0090210885,-0.036954187,-0.05287802,0.019009193,-0.010081248,0.029522281,-0.048914894,0.013633263,-0.110655084,0.00734421,-0.07209309,0.055372905,0.026220873,-0.099652566,-0.057432808,-0.011301512,0.042080116,-0.004105576,0.061992988,-0.044767372,-3.223689e-05,-0.0114694815,0.013816932,-0.053658966,0.05075669,-0.074452944,-0.030295003,0.03423142,-0.10267486,-0.03100442,0.022738563,-0.04455464,0.06508932,0.037176657,0.17878751,0.012470436 +2.7.1.165,"A key enzyme in the nonphosphorylative Entner-Doudoroff pathway in archaea [1,2]. In the bacterium Hyphomicrobium methylovorum GM2 the enzyme is involved in formaldehyde assimilation I (serine pathway) [5]. In Escherichia coli the enzyme is involved in D-glucarate/D-galactarate degradation [6]. The enzyme requires a divalent metal ion [1].",384,1.0,0.03227841,-0.06940194,-0.047008242,-0.013802469,0.09886729,-0.028797867,-0.06382712,0.010126292,0.024395898,-0.02166845,-0.009127777,-0.057247166,-0.004335246,0.05322914,-0.0677799,0.021206839,-0.069145136,0.047863964,0.034609262,0.015233634,0.061528623,0.08389592,-0.018650144,0.011341873,-0.028100021,-0.038442288,0.03242546,-0.03997726,-0.0675277,-0.0046398933,-0.024423828,-0.008855907,0.0711145,-0.021588922,0.075131975,0.10836289,0.020332187,0.0124040255,0.01604437,-0.049497675,0.031565923,0.016249493,0.0055224923,-0.020036487,-0.05966457,-0.027424885,0.028609848,-0.0059352857,-0.02704109,-0.0007681279,-0.09317913,-0.0029580581,-0.052561864,-0.023086034,0.03244076,0.052068513,0.012151,-0.056742042,0.020745263,-0.05453666,0.062197942,0.00748842,0.01389075,-0.046785638,0.061051946,-0.0711428,0.079720564,-0.053674225,0.006583291,-0.042451806,-0.07920554,-0.058672316,-0.032637328,-0.0044261925,-0.042545415,0.046562325,-0.00041218378,-0.05094447,0.10825267,-0.03979661,0.042793527,-0.0072630844,0.04773619,0.008149892,-0.0003134389,-0.030625707,0.028840175,0.022913234,0.05099427,0.015706357,0.0054645003,-0.04519401,-0.035205625,-0.08917737,-0.05752766,-0.005453065,0.014597205,0.041556507,0.04163582,0.017956747,-0.041314393,-0.0013651575,-0.04488945,-0.049922556,-0.09860755,-0.0153956525,0.0200349,0.1321228,-0.0057040225,0.03989718,0.013895428,-0.01298827,0.061600763,0.053974003,-0.026233964,0.07810391,0.07836179,-0.0608903,-0.13645558,0.011516158,-0.010134169,-0.047378134,0.085640766,0.04957417,-0.056630068,0.021812566,-0.064981215,2.5548938e-33,0.1044656,0.014735041,0.03673418,-0.05309957,0.023873918,-0.024490878,-0.080256276,0.0084706815,0.021722542,-0.028169008,-0.037053823,-0.07180869,0.01908363,-0.010985112,-0.080747865,0.003992868,-0.03596176,0.0110729905,0.040852994,0.024146391,-0.0032572516,0.086410865,0.010410024,-0.013628873,0.070879854,0.008958946,0.009143383,-0.014548729,0.071317546,0.017383382,0.053123392,-0.17910902,-0.13101487,0.0034907423,0.104535334,0.005757182,-0.023124082,0.016082106,-0.06498955,-0.052681334,-0.028645115,0.044970356,-0.028669192,-0.0593993,0.042120133,-0.046279646,0.051166743,0.07657496,-9.851488e-06,0.070437305,0.019555347,-0.07410333,0.023375867,-0.05763382,-0.09926638,0.006193907,0.0016009851,-0.013673099,0.05102652,0.07400082,-0.018098086,0.02035541,-0.042209342,0.02640183,0.03134855,-0.009229543,-0.064037524,-0.00939641,0.039906427,0.022065196,-0.022077585,-0.033181787,0.04508452,0.055582147,-0.06976015,-0.044786204,-0.07168001,-0.04765674,0.015136522,-0.05721762,-0.033439726,-0.010504675,0.0062740846,0.021662211,0.00042116185,0.029434217,-0.05409926,-0.007310519,-0.054084152,0.0037035053,0.0607135,-0.026304586,-0.0313535,0.056390677,0.05390682,-4.1018405e-33,0.073626064,-0.08015305,0.06280058,-0.068772525,-0.041098505,0.11052974,-0.0021602868,0.05842414,0.069058366,-0.0695361,0.097395524,0.047265522,0.031602424,-0.066889115,0.036651358,-0.0759813,0.057394333,0.08153763,-0.037065066,-0.039782144,0.052434046,0.0006327877,-0.035235975,-0.0312894,0.023991207,0.07644076,0.017112033,0.1094838,-0.036301125,0.059393402,0.025734248,0.0712185,-0.03012516,-0.047254387,-0.0031836173,0.018587735,-0.05053539,-0.009330997,-0.042001795,0.024164554,-0.03989048,0.05243616,0.015850699,0.041061617,-0.02592942,0.069320045,-0.11179794,0.0141721405,0.099825315,-0.019319668,0.037687033,-0.057406146,-0.040660083,-0.027957425,0.013014402,0.057110533,0.067966044,0.081938,-0.044022005,0.0068194545,-0.03263758,-0.032125507,0.016271144,-0.0032022125,0.044360816,0.031482782,-0.008621815,0.06614208,0.026749356,-0.030652862,0.014471718,0.010110825,-0.0033047856,0.08810185,-0.019480977,-0.06543711,-0.027640961,-0.051814925,0.08299293,-0.007985943,0.013633964,0.035551,0.00837698,-0.02211827,0.044641666,-0.10985516,0.046540655,0.09821117,-0.0047013974,0.031459663,-0.0476022,-0.036935378,-0.053501848,0.0063888356,0.010531191,-4.2283038e-08,-0.0026802889,-0.078754365,0.023349019,-0.062748365,-0.055021577,0.017041342,0.019001985,0.037828688,0.055362705,-0.024687212,0.06679119,0.07067198,-0.0032202874,-0.009920945,0.024636246,0.012563199,-0.02410906,-0.015018678,-0.098776415,-0.058741968,-0.057921134,-0.028249664,-0.124333054,0.038979944,0.05387,-0.07246974,0.02682315,0.044117037,-0.027018592,-0.0373234,-0.006724907,0.019395942,-0.044860065,-0.0061056926,-0.14210005,0.014562426,-0.057185885,-0.016738696,-0.04690378,0.03764673,0.041001007,0.033477623,-0.07538777,-0.013120496,0.030816507,0.06272362,-0.05708846,0.09600178,-0.0616525,0.05082235,0.03623525,0.014748073,-0.0363967,-0.019793345,-0.11281091,-0.011702446,0.008905266,-0.049817603,-0.004157263,-0.04054761,0.08989181,-0.004980201,0.15839294,-0.083544075 +2.8.4.2,"Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione.",384,1.0,0.08914405,0.045341622,0.019761669,0.019986313,0.1468876,-0.022809222,0.096765585,0.09742368,0.07578109,0.01372592,0.023891062,0.006193201,0.05530579,0.016393604,-0.09855483,-0.03944151,-0.0628423,0.10520571,-0.039839197,-0.019823337,-0.005488589,0.0092607625,0.029500924,-0.011169681,-0.06350244,0.05422712,0.043933596,0.02086783,-0.07503946,-0.090256505,-0.031496566,-0.058010057,0.03745584,-0.03793884,-0.10094921,0.07618245,-0.08942839,-0.002944179,-0.011127792,-0.07401124,0.012695178,-0.02298493,-0.047568236,-0.013979115,-0.035581734,0.024751347,-0.034732774,-0.03842608,-0.0061712386,-0.014324134,-0.052127462,0.067422174,-0.044753797,0.055262823,0.08051273,0.009189458,-0.04731376,0.026611691,-0.06414127,0.08359027,0.06534918,0.028824348,-0.071907915,-0.037487652,0.036921013,-0.04719946,0.07072553,0.039960902,-0.048407074,-0.012133015,0.075019754,-0.025245944,0.0034082867,-0.0077985376,0.034688435,0.102665134,0.0345673,-0.055944655,0.029591335,-0.036111582,-0.01575576,0.049352586,0.13832459,0.033358026,0.009139898,-0.044884723,0.00023619633,-0.08812359,0.014919045,0.07167097,0.13990207,0.034594487,0.034546606,0.020253854,0.01241768,0.024722097,0.058686562,0.07460543,-0.027313745,-0.013489464,-0.015504478,0.014755884,-0.20032212,-0.07429698,-0.029565819,-0.059218995,0.011904017,-0.013994189,-0.01900619,0.04057205,0.029711848,-0.058186777,-0.04662915,0.022002827,0.000621259,0.08635685,0.087678425,-0.027023695,-0.03292668,0.00042084075,-0.0063246987,0.045305144,0.033232104,0.0035342907,-0.064444706,-0.021523342,-0.0431914,5.0775365e-33,-0.03859634,0.10829625,-0.1172693,0.008855473,0.03552633,-0.089188546,-0.11443735,0.04272976,-0.0015456215,-0.03750781,-0.04742212,-0.06989491,-0.06690624,-0.010920507,-0.047816385,-0.074149035,-0.042895224,-0.002953243,0.07583083,-0.004600072,-0.027053589,0.02016449,-0.012033512,0.018309925,-0.013757235,0.008038729,-0.0051658843,-0.008444371,-0.052639198,0.00014878072,-0.0048021046,-0.012466109,-0.09839524,-0.04473232,0.026785769,0.027577331,-0.04931368,-0.024507668,-0.06902787,0.013580389,-0.032278463,0.030971123,0.004484629,-0.025094282,0.054970223,-0.10041825,-0.06857928,0.046991397,0.0371527,-0.04321007,0.041805744,-0.01577542,0.12120067,-0.075913906,-0.05655129,-0.017898304,-0.041187085,-0.054085996,0.019001724,0.08604532,0.047399174,-0.032250896,-0.056050222,0.0881168,0.017805368,0.03770843,-0.059468444,-0.048861172,0.007449016,-0.021578468,-0.032957204,-0.015155687,0.092893936,0.005834468,-0.003736292,0.0021754636,-0.0892439,0.028440688,0.008529761,-0.057106975,-0.035630725,0.015548263,0.007854471,0.0013399463,0.038517628,0.007802424,0.009941448,0.021498509,0.070896655,-0.020476393,0.025026135,-0.110938475,-0.098654404,0.030049717,-0.012771992,-5.187187e-33,-0.0016970731,-0.053938016,0.057017043,-0.03103127,-0.061299637,0.06425396,0.015011735,0.06719316,0.018389143,0.047345985,0.075436264,-0.049403228,0.037709504,-0.0433809,-0.057732947,-0.01927105,0.005148088,-0.014984815,0.002308834,-0.036171533,-0.07106542,0.06449738,0.011417626,0.0007877879,-0.009361085,0.010585592,-0.013823197,0.034242675,0.12521316,0.00936365,0.0229199,-0.0045878137,-0.03365088,-0.06469894,-0.040946692,0.048072163,-0.01835711,-0.0029957658,-0.040684782,-0.014566374,0.009553263,0.035004668,0.0019661502,0.084681205,0.06244772,0.02140525,-0.06864497,0.06791714,0.09643423,-0.04816852,0.03393712,-0.037118234,0.03787342,0.00946649,0.034840994,-0.056237683,0.10691361,-0.03272406,0.0041637016,0.03708468,-0.057198334,-0.02407008,0.0053029726,-0.031106623,0.08386579,0.057351805,-0.060735058,0.09053953,0.07339746,-0.04486599,0.038099278,0.009707055,0.03623644,-0.06969282,-0.02432043,-0.024599511,-0.014883533,0.029388588,0.023026945,0.019667424,0.090109624,0.032092925,-0.026646055,-0.06932246,0.0019160578,-0.050511923,0.033158705,0.14269413,-0.10205865,0.042687707,-0.0039354316,-0.019954583,-0.051289678,0.018852487,-0.013556646,-4.0228173e-08,0.05465052,0.013290252,0.052572116,-0.046292715,-0.009267891,-0.035683215,-0.0069944803,0.020068165,0.059822466,-0.06066721,-0.01696202,0.05994846,0.05172437,0.029925006,0.039298527,0.008871597,0.0022261506,0.030204164,-0.004301609,-0.011636134,-0.07146888,-0.052447595,-0.013946064,-0.03937306,0.036096912,-0.030051006,0.028868055,-0.046108324,-0.03846594,-0.015873482,0.011795333,0.004767937,0.059528194,0.02422375,-0.077537015,0.0637823,-0.0017513243,-0.08374261,0.024860054,-0.0015337907,-0.032016855,-0.081686586,-0.036318745,0.05138299,0.025706798,-0.009118816,-0.05622778,0.0029353246,-0.0126133235,-0.050655082,0.009353956,-0.00040499613,0.08006152,-0.06567836,-0.05428827,0.028444562,0.052656967,0.0014239155,0.09091844,-0.027216587,0.0035711525,-0.028424649,0.093945034,-0.019151127 +3.1.1.84,"Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy [2,3].",384,1.0,-0.04250517,-0.045186874,-0.08780497,0.053843554,0.019107439,0.06187764,-0.04180145,0.045813326,-0.045339823,-0.022758741,-0.05411411,-0.07852698,-0.030106569,0.05386786,0.01829993,0.003421141,0.029768553,-0.03335844,0.014625489,0.111309074,0.12188279,0.032044638,0.0043693855,0.010049816,-0.024534741,0.11949452,0.0029384752,-0.012197223,-0.025393099,0.0058267876,-0.06345497,-0.03082709,0.056483418,-0.030915469,0.017525077,0.027569368,-0.044124242,0.053095743,0.11462709,0.048711367,-0.09807957,-0.016435748,0.11040395,0.0019402828,-0.07110209,-0.049404867,-0.019776609,0.072584495,0.079986535,-0.15235232,0.012870742,-0.0057275165,-0.0031545071,0.12815318,0.051183823,0.012828403,-0.061857,-0.011075176,0.025009196,0.04864421,0.02878054,0.06661333,-0.0010039848,0.031973943,0.028405674,-0.030492451,0.0026354548,-0.021861276,0.04968255,0.021771323,-0.05574986,-0.07469339,0.0013526336,-0.03306574,0.0049109533,0.06103849,0.04130324,-0.04721562,-0.009678558,0.021629475,-0.052367613,-0.010797201,-0.017242992,0.051727474,0.007106158,0.009034679,0.030892171,-0.019708313,-0.06258333,0.055393245,-0.014301969,0.026085092,0.01694664,-0.07818284,-0.08331169,-0.065094255,0.008664822,0.045661908,0.017441511,-0.034980197,0.01567065,0.080688395,0.0049338317,-0.05798713,0.007951063,-0.0404863,-0.014484662,0.09689379,0.1271087,0.036120832,0.035100557,0.089496784,-0.055472296,0.00903345,-0.010801784,0.04446069,0.017982226,-0.06830952,-0.10698029,0.045519363,0.00696557,-0.10250322,-0.016697805,-0.064445354,-0.024037743,-0.10946184,-0.048853803,2.6895643e-33,0.015296518,-0.03513214,-0.033270754,-0.033684358,0.067689575,0.040677365,-0.10273119,0.027394246,0.059074122,-0.003291305,-0.009469698,0.014987415,0.0039747404,0.080738865,-0.053626116,0.0037734336,-0.06097357,-0.10976177,0.059835263,-0.03329527,-0.0125637995,-0.043794673,0.015641265,0.013735439,-0.03092673,0.05895118,-0.040713042,0.0066449083,0.019233258,-0.0037641942,0.026986295,0.00040146642,-0.044034302,-0.008239333,-0.056989364,-0.016649922,0.039701074,-0.00287808,-0.015516471,0.0058536623,0.036348123,0.117927246,0.021338655,-0.067626126,-0.005030661,0.0051426445,-0.06687764,0.06953581,-0.004657753,0.06817423,0.008162415,-0.05034853,0.009170021,-0.0037268999,-0.028468486,-0.026865572,-0.012593193,-0.003634015,0.0043873237,0.031930484,0.07492812,0.09656033,0.023175152,0.06546232,0.0139352,-0.017513929,0.028567404,-0.06889262,-0.03535332,0.026847625,-0.05745174,0.0063798507,0.011365156,-0.05000245,0.0015756683,-0.046926398,-0.050829586,0.02771613,0.02093986,0.05259502,0.0056276848,-0.09655083,0.06995185,-0.0017605972,-0.07296584,0.06638745,0.0610223,-0.05874554,0.025079058,0.032668427,-0.049720332,-0.098593295,-0.021006381,-0.021080201,-0.017097592,-4.28522e-33,0.04656371,-0.06641063,0.060828596,-0.047586422,0.04043672,0.029949166,0.015768688,-0.053700726,-0.043323476,-0.025948867,0.08293561,-0.0029154643,0.051904898,0.046851076,0.09827102,0.007255488,-0.064667605,-0.018995928,-0.062453266,0.012867192,-0.041688208,0.012280465,-0.10808216,-0.024044838,0.039674003,-0.0109406235,-0.067945294,0.04119895,-0.017296437,0.017336186,-0.016437579,0.131985,-0.060671236,-0.046281904,-0.07870822,0.07960229,-0.01383455,0.041086838,0.0072964556,-0.025984066,0.09173978,0.034782536,-0.092854634,0.043279745,-0.053678174,-0.03145785,-0.050702546,-0.023740705,0.02563562,0.009856107,0.080418736,0.0230156,-0.059427686,-0.021310745,0.00922568,-0.008763833,-0.042193,-0.024772951,0.010910667,-0.06450535,-0.120466925,0.031119695,-0.08945722,-0.029818334,0.031305008,0.026828928,0.034336403,0.051487733,0.09034251,0.019525398,0.037597034,0.028360274,0.09249802,0.0055975677,-0.10690251,-0.04325753,-0.08370314,-0.027320815,-0.027823595,0.024349915,0.04172329,-0.0057706223,0.01785743,-0.0020777988,0.061131533,0.0074614603,0.041082878,0.03714853,-0.061726443,-0.02313139,0.010853247,-0.03442497,-0.03587666,0.008506088,0.05043879,-3.1780022e-08,0.01737071,-0.058023825,0.061762217,0.06954587,0.05297631,0.12107631,0.045974605,-0.0022026682,0.008743737,0.014913787,0.049971454,0.077748485,0.04875311,0.024676677,-0.00986928,0.016043585,-0.11372588,0.021026472,0.015624653,-0.0023523746,-0.09434664,-0.06396268,-0.0033155612,0.0054809335,0.011588815,-0.08194455,0.06691662,0.0034231814,-0.041072793,0.01324474,-0.03224614,0.036320113,-0.04569276,0.013600564,-0.018314673,-0.075360686,0.009430757,-0.024247944,-0.08097055,0.013643496,0.03622922,-0.0363908,-0.11412372,0.0033306787,-0.018010078,-0.08794461,-0.08384627,0.01808316,0.0402174,-0.036058098,0.06955984,-0.008733999,0.020720776,-0.052650057,0.00593648,0.06812121,-0.038405884,0.010001456,-0.09223432,0.0108321225,0.0007079845,0.003926143,0.098043494,-0.09261037 +4.1.2.45,"This enzyme is involved in naphthalene degradation. The enzyme catalyses a retro-aldol reaction in vitro, and it accepts a broad range of aldehydes and 4-substituted 2-oxobut-3-enoates as substrates [4].",384,1.0,-0.012857945,0.088987574,-0.056324374,0.006190328,0.00048698238,0.051499624,-0.076824866,-0.04594106,0.061235145,-0.031076392,-0.061322358,-0.02506756,-0.051467713,0.01935944,-0.027701188,0.123367935,-0.054826215,0.050102025,-0.02150491,-0.021774279,0.0057867477,0.03795822,0.039354566,0.0140722655,0.06837551,-0.0187764,0.023052277,-0.046398222,-0.049293667,-0.09087929,-0.0007459377,-0.04320817,0.0029780199,-0.07470209,0.008712127,0.09072032,-0.07148204,0.003683177,-0.0042738863,0.050252862,0.06838742,-0.03396689,-0.10967742,-0.025775902,-0.03675477,-0.007958842,-0.05078386,0.033166055,0.0527594,0.050645877,-0.016203197,-0.0600037,-0.020520559,0.06524356,0.0076436982,-0.046093505,-0.020122794,0.07132078,-0.04661599,0.070715345,0.11527877,0.01621618,-0.026164299,-0.003999776,0.0023678725,-0.06725173,0.018265571,-0.085902564,-0.016879551,-0.027128473,-0.050076943,-0.1281727,-0.013576267,0.018065562,0.006819826,-0.036392312,0.00050249655,-0.049939908,0.021599421,0.00016657547,0.10663366,0.009798544,0.016588446,0.0915794,0.07241267,0.024511334,-0.029486282,-0.038542274,-0.0010227966,-0.003585989,-0.011603421,-0.040792644,-0.04725218,0.0011511385,0.021674061,-0.026773676,-0.018520923,0.05832103,0.0055294745,0.014873602,0.0046283826,0.047131304,-0.033213425,-0.12206573,-0.046616223,0.037111834,0.007865149,0.07199791,0.03488982,-0.01735162,-0.03293245,0.0070996885,0.03531013,-0.006044687,0.0055625304,0.1130459,-0.0074017216,-0.048422344,-0.10184967,0.002635055,-0.0075526163,-0.039697845,0.06367993,0.050355263,-0.047580138,0.02410586,-0.08256659,-8.441417e-34,0.1058349,0.03095849,-0.009523917,0.01314298,-0.0013306077,-0.041927543,-0.029176828,0.005011826,-0.0444253,-0.067389145,-0.02827643,-0.055964254,0.04976346,0.048323944,-0.004986953,-0.014507958,-0.07388525,0.028145965,0.07414449,-0.038662523,-0.019175248,0.03850193,-0.08318292,-0.012712717,-0.023239028,0.067064166,0.04311416,0.055279274,-0.070750244,-0.02637995,0.07056943,-0.01134915,-0.16935384,-0.064132094,0.00069800706,-0.022468956,-0.0011042862,0.017008388,-0.026120225,0.05193945,-0.040380545,0.04149237,-0.008767215,-0.09045764,0.018471008,-0.056769658,0.006820222,0.19753389,0.09738775,0.06451934,0.09768256,-0.061995488,0.055497967,0.0074851643,-0.08170514,0.025955487,-0.0039352933,-0.03754153,0.044542484,0.04567574,0.03791746,-0.0029183913,0.019356234,-0.029020576,-0.023018014,-0.020824358,-0.08064452,-0.008957949,-0.036961164,0.062106915,-0.015618005,0.013096452,0.047096387,0.008853555,-0.0137880845,-0.04581473,-0.07059066,0.021621536,0.07087718,0.003139901,0.065611,-0.01288874,0.027880453,0.014269242,-0.041101232,-0.06639501,-0.00017962616,-0.052457396,-0.029594531,0.08958633,-0.023245597,-0.012192098,-0.10135731,0.015637958,0.036239896,-9.919568e-34,0.13153592,-0.07001711,-0.025341617,-0.054617144,-0.032104265,0.00941729,0.036935326,0.04547267,-0.028282464,0.026174732,0.09688631,0.012292484,0.095624946,0.0031187544,0.06358799,-0.05705456,-0.07337776,-0.02479283,-0.030800924,-0.08705562,0.05181021,0.05166449,-0.068081304,0.019758545,-0.0013026677,0.036022983,-0.027938511,0.013902234,0.09638547,0.027070537,-0.009459854,-0.03247673,-0.019107196,0.050040215,0.042105038,0.13053992,-0.039082404,0.01844625,-0.012005131,-0.007905476,0.0026707056,0.02571849,0.02427005,0.036648236,0.08745818,0.008939851,-0.05806448,-0.033829544,0.037623577,-0.07372637,0.068275146,0.034538448,-0.019497082,0.018586563,-0.019578898,0.09124674,0.0049787867,-0.072941266,-0.0071044015,-0.021554016,-0.07338218,0.013889307,0.12957926,-0.05740124,-0.030093849,0.03948138,0.024197485,0.024070142,0.012234479,-0.010339237,0.12540543,-0.039379343,0.0023155238,0.031299468,-0.049879834,-0.07134351,-0.032873627,0.04125503,-0.014251164,-0.02229109,0.006297108,-0.023166798,0.018679056,-0.08378658,-0.025194997,-0.035795312,0.021834454,0.082068406,-0.011190982,0.023219382,0.02344214,-0.029368171,-0.10440029,0.06920213,0.028508553,-3.394393e-08,0.010226945,-0.027350118,0.05066198,0.028369619,-0.065369375,0.0075480025,0.06110114,0.041457128,-0.0020776072,-0.011854671,0.0066798665,0.08687126,-0.0028505737,0.012878936,0.07430381,-0.013215398,-0.03910957,0.017224865,-0.009807345,-0.040769972,-0.066275746,0.006832726,-0.058925014,-0.030485515,0.00036035606,-0.037728306,0.01175097,0.050173853,0.05026088,-0.03271982,0.00405824,0.083739825,-0.013015124,-0.04488544,-0.055954617,0.034266863,-0.07292117,-0.013044818,-0.041534822,0.026927164,-0.064143404,-0.03914334,-0.04063383,0.012705356,0.053510852,-0.010562323,-0.019488484,-0.036206108,-0.08872756,0.035755023,0.0552349,0.0060418285,-0.0066714194,0.00580272,-0.101358734,0.052883748,-0.042870212,-0.070486575,0.04912058,-0.07081066,0.010027147,0.0143786,0.17226912,0.013355975 +5.99.1.4,This enzyme is involved in naphthalene degradation.,384,0.9999999,-0.0030920636,0.059760597,-0.0605759,0.003078272,0.0405522,0.03215553,-0.042184036,0.008149403,0.0480191,-0.051916987,-0.0689963,0.03407447,-0.010056315,0.0650503,-0.030900735,0.07260747,-0.070645094,0.027858676,-0.03131737,-0.04312648,0.031757772,0.081645094,0.023262361,-0.020320952,0.06389715,-0.028297232,0.044291113,-0.085764945,-0.022082772,-0.067044005,0.017127108,-0.027008664,-0.018468317,-0.014971794,0.017801628,0.09364016,-0.07972476,0.012488487,0.010926772,0.018791856,0.05360706,-0.016272973,-0.104127795,-0.085599534,-0.028799614,0.02102551,-0.08336416,0.012194597,0.041036885,0.06069337,-0.079154216,-0.051799078,-0.020810952,0.03739226,0.0049929176,-0.039855566,-0.011136786,0.03939109,-0.08668905,0.04047259,0.07315521,0.008831536,0.013056275,-0.005916079,0.023955598,-0.07259639,0.07497369,-0.043985695,0.024059273,-0.021155965,-0.07354797,-0.11333349,0.008816276,0.03222078,0.018912569,-0.04296298,0.013421521,-0.080150835,0.025803529,-0.037146464,0.108479746,0.004844111,0.004885507,0.08664972,0.05404971,0.059030488,-0.0149777,-0.034539107,-0.0075406497,0.009617321,0.0063855876,0.010511077,-0.044322666,0.0016908342,-0.025359655,-0.04095289,-0.024358094,0.034905866,-0.035392616,-0.006977699,-0.038053915,0.025654493,-0.06331187,-0.12274678,-0.08835832,0.010813123,0.014282474,0.01858061,0.061279077,-0.0137608275,0.032942295,0.055324253,0.06429022,0.015198377,-0.011951704,0.09583451,0.00964958,-0.025863746,-0.11440212,0.0491444,-0.019656168,-0.080424145,0.025899658,0.03486964,-0.051445447,0.021715717,-0.09029735,-2.1799947e-33,0.029522493,0.033856556,-0.0031509514,-0.021947352,-0.0092134755,-0.06315434,-0.027365057,-0.018206913,-0.048716653,-0.07979684,-0.0066310978,-0.08346174,-0.013848842,-0.008316628,0.014679363,-0.006436405,-0.035221014,0.05975898,0.041600794,-0.041120246,-0.023103308,0.031064916,-0.062767684,-0.0353507,0.0078706555,0.060998194,0.03787991,0.082991585,-0.07719725,-0.049281407,0.072135076,-0.025097093,-0.12810265,-0.000465543,0.07478248,0.010929509,-0.017696325,0.018193973,-0.029220417,0.018522663,-0.07414339,0.0054288907,-0.03247373,-0.044517342,0.0026830868,-0.06913435,-0.037379406,0.16909969,0.07139592,0.0383365,0.06299879,-0.082409136,0.11894427,-0.036868315,-0.050604753,0.029214127,0.004710979,-0.08422394,0.060721695,0.06336369,-0.016324218,-0.025148463,-0.042116884,-0.013537545,0.021488242,-0.010004637,-0.09271064,0.007124892,0.006892474,0.074233636,-0.010893483,0.0025644943,0.06895474,-0.009202976,0.015694458,-0.039141566,-0.05917589,0.07066899,0.053408746,0.03283022,0.068048075,-0.05468819,0.018393297,-0.013266841,-0.06967794,-0.0439379,0.014668001,-0.03483213,-0.011187708,0.05987963,0.005699231,-0.06994747,-0.08526317,0.0009808277,0.0073009995,4.1206e-34,0.10804754,-0.046562035,-0.048957348,-0.036953114,-0.0035084856,0.042570986,0.05637598,0.06546791,-0.012668886,-0.0033972175,0.07797063,-0.004592956,0.048892554,-0.017970372,0.0043834588,0.019022306,-0.006388954,-0.010861558,-0.035318173,-0.04523834,-0.013316695,0.08383709,-0.06538716,0.08837218,-0.034874998,0.031772267,-0.062299307,0.07557929,0.06839287,0.010268904,0.048422296,-0.029847635,-0.051548693,0.040297847,0.010044376,0.05764695,0.0029685528,0.0027952131,-0.008911522,-0.05639259,0.008026301,0.018499713,-0.0018252151,0.019119345,0.0852129,0.04467284,-0.049447544,-0.01815138,0.0035133357,-0.058679756,0.049470596,0.058836196,-0.0023236752,0.029047271,-0.030767417,0.08618613,0.027510077,-0.047537383,0.005740444,-0.0129888505,-0.019883344,-0.023414055,0.071470566,0.020782053,-0.034232773,0.0043588164,0.029044997,0.04663872,0.07021789,0.0054690656,0.054878563,0.02513474,0.02849584,0.014829702,-0.111542754,-0.06523497,-0.026603144,0.03770665,0.025573948,-0.02680406,0.023060422,0.0015317594,-0.02868279,-0.1134247,-0.004231157,-0.027616099,-0.008233911,0.08952838,0.042525884,0.01702592,-0.013784555,-0.05465894,-0.14760444,0.026013447,0.009219953,-1.8471395e-08,0.059917603,-0.07114272,0.06622483,-0.036419004,-0.048713565,-0.03526348,0.09190126,0.068722695,0.011614177,0.0033186655,-0.0339372,0.10125471,-0.017507149,-0.020937497,0.035670795,-0.011935936,-0.026459366,0.050321292,-0.0038040753,-0.039678942,-0.07036396,0.013264277,-0.098352745,0.032430995,0.02684998,-0.038632,0.056522116,0.07678275,0.038612347,-0.061689254,-0.04259043,0.06993627,0.03904574,-0.04517693,-0.060000528,0.032305405,-0.0071430528,-0.0044313623,-0.009083557,0.09857147,-0.046178043,0.03509879,-0.052879028,-0.0073437104,0.052696194,-0.003387016,0.02541388,-0.055893324,-0.009880187,0.002924169,0.06129771,0.024472447,-0.059060764,-0.017294617,-0.10673405,0.024954906,-0.034030534,-0.06929474,0.035556387,-0.052417483,0.046450518,-0.013641218,0.24640217,-0.0054942593 +6.3.2.31,"This protein catalyses the successive addition of two glutamate residues to factor F420 (coenzyme F420) by two distinct and independent reactions. In the reaction described here the enzyme attaches a glutamate via its alpha-amine group to F420-0. In the second reaction (EC 6.3.2.34, coenzyme F420-1:gamma-L-glutamate ligase) it catalyses the addition of a second L-glutamate residue to the gamma-carboxyl of the first glutamate.",384,1.0,0.015101519,0.006889997,-0.0037579963,-0.0059797764,0.036808074,0.044144038,-0.01855655,0.065101795,-0.03401804,0.028604848,0.05404631,-0.04582932,0.019151155,0.05723068,-0.014037228,0.00254716,-0.072308555,-0.042961534,-0.10109226,-0.07653995,0.062334802,0.018240523,-0.05099279,-0.065843776,0.016438201,0.0734766,0.045766186,-0.040293597,0.050975733,-0.06338884,0.021919955,-0.02331265,0.06292736,-0.0069198594,0.0021502026,-0.005456039,-0.077240326,-0.11000788,0.06307165,0.0067288517,-0.032262925,0.084477514,0.018001571,-0.054276202,-0.020138076,-0.0016253862,0.06726242,-0.029139781,0.04346156,-0.0095144035,0.055994615,0.015174426,-0.023523778,0.06472048,0.045198172,0.02933512,-0.013248994,-0.058596786,-0.052262966,0.09661074,0.030634409,0.00904183,-0.033805344,-0.04257729,0.06801309,-0.015903348,0.028824257,-0.047874197,0.015280388,-0.021759301,-0.017640911,-0.012861999,0.01846309,-0.027387245,0.027802931,-0.0411883,0.0028702384,-0.046095446,0.02564277,-0.012355241,0.09028753,-0.04136186,0.10207117,0.023061894,0.073821604,-0.027646245,-0.037764806,0.0013874234,0.056128465,0.030286023,-0.00953401,-0.019844923,-0.04038442,0.004240785,-0.10614366,0.040927563,0.004681957,-0.0054632835,0.014804256,0.022916116,-0.027408104,0.03739849,0.00355784,-0.046012603,-0.024445904,0.045650937,0.009043935,0.08852083,0.0044263843,-0.008003374,0.011800718,0.011474778,0.043625053,0.0064368793,-0.0286693,0.045421664,0.014789973,-0.043655775,-0.014302091,0.013838547,0.06605573,0.0024645985,0.009781176,0.031901956,-0.04756074,0.018912092,-0.184532,4.7169334e-33,0.049885076,0.08250874,-0.03550844,0.021824634,0.05433501,-0.038326662,-0.044764396,0.06578014,-0.021137314,0.0029141838,-0.08394752,-0.07626357,0.04572657,-0.038643137,-0.05588923,-0.08131608,-0.027475392,-0.014419937,0.028388958,-0.0023583584,-0.008806079,0.072096415,0.020840485,-0.030149937,0.096926965,0.048372254,0.0059302845,0.046484713,0.05949204,0.021550292,-0.040101584,-0.052268583,-0.13401034,-0.015702026,0.05620221,-0.043524362,-0.037441526,-0.07118466,-0.03977331,0.06192757,0.04800993,0.026032878,-0.10312167,-0.028180512,0.019047556,-0.05544787,-0.022576384,0.10139268,0.05851915,0.1264928,0.024437824,-0.03420191,0.04505226,0.0025111067,-0.06190439,-0.01029469,-0.073366836,-0.0830886,0.060623426,0.038753886,0.013742145,0.036351822,-0.08753146,0.05930947,0.050184663,0.014228433,0.016249312,-0.072490975,0.0067748744,0.05771223,-0.044552594,-0.028682716,0.07414541,-0.032168604,0.04563203,-0.045184392,-0.04038328,-0.058337875,0.074442275,-0.0148634035,-0.016781032,-0.0012692153,-0.015463923,-0.0042690868,-0.03463264,-0.013460523,0.017523682,-0.0661759,0.0420131,0.045355756,0.028971845,-0.06040415,0.06283694,0.034679946,0.03594035,-4.056375e-33,0.04792295,-0.08449119,-0.023740772,-0.07528471,-0.050260328,0.018052286,0.0034578538,-0.077322416,0.013020252,-0.011425715,0.09022683,-0.015794381,0.04731706,-0.028353503,-0.00092013995,-0.0049631493,-0.022393731,0.059880693,-0.016105417,-0.027267778,0.047252003,0.077918045,0.066141665,0.021148607,0.030094936,0.024761194,0.04365562,-0.0014198633,0.049724013,0.09144729,-0.029190376,-0.06279548,0.018490696,-0.052496556,-0.047628522,0.030320723,0.023340767,-0.012746117,0.012146138,-0.027328223,0.010574319,0.10936269,0.024668125,0.013549952,0.009107465,0.04957254,-0.012187926,-0.0137318075,0.023673685,-0.0968001,0.046611365,-0.07524318,-0.099537104,-0.06985805,-0.1017418,0.003498822,0.048639555,-0.042648118,0.033406857,-0.004042711,-0.018357158,-0.0641305,0.041987993,0.0039258962,0.09729303,0.033359703,0.019595973,0.022829155,0.061590154,0.007312072,0.041591052,-0.03843691,0.027648099,0.12423138,0.0370256,0.019158162,-0.07949416,-0.033316188,-0.02625708,-0.020033674,0.026179379,-0.044866055,-0.004595928,-0.026257008,-0.04223966,-0.16388498,-0.051760748,0.14639261,0.06796319,-0.018073719,-0.06595241,0.028629744,0.007821712,0.10276665,0.085551016,-3.9988127e-08,-0.015198122,-0.0370124,-0.07749781,-0.027877774,0.029934961,0.085079074,-0.060634352,-0.04660692,0.06817888,-0.04323944,-0.006906424,0.1133779,-0.049941543,0.056694873,-0.027584663,0.016260812,-0.021695314,0.0076488843,-0.029484328,-0.01969553,-0.053013124,0.001511261,-0.045021508,-0.005591536,-0.017245587,-0.07516539,-0.010627243,0.123940684,-0.03845829,-0.057206906,-0.038422275,0.08101966,-0.019105764,-0.04861502,-0.10040883,0.020326551,0.07194099,-0.0031079508,-0.075334355,0.044124424,0.023295255,-0.05386255,-0.07467212,0.0009667876,0.04226287,0.01921278,0.04433186,-0.019703746,-0.04551958,-0.019577278,0.06616361,-0.019399226,-0.004786831,0.03413182,-0.106027074,-0.048997305,-0.057150044,-0.016191188,0.020575617,-0.0888151,0.024634482,0.0472575,0.13159955,-0.059354663 +6.3.2.32,The enzyme caps the gamma-glutamyl tail of the hydride carrier coenzyme F420 [1].,384,1.0,-0.0034188572,-0.0065488727,-0.05035396,-0.059949644,0.048354886,-0.023819963,-0.027410893,0.06554107,-0.038116843,-0.038398564,0.08076853,-0.045527752,0.06133424,0.05445454,0.0056814295,-0.010934931,-0.04132157,-0.10724006,-0.009753112,-0.070567325,0.03357184,0.037544183,0.0073816185,0.029013982,-0.053470455,-0.005793519,0.03697874,-0.026456852,-0.0035911787,-0.07027703,-0.0352567,-0.03363268,0.030120602,0.0030768563,0.035310254,0.064757414,-0.091978535,-0.05807915,0.08246448,0.029231569,-0.007345084,0.011626471,0.0007733727,0.0057412027,-0.07673763,-0.013375197,0.044295613,-0.01890868,0.035800256,0.018693183,0.05614006,-0.0020758037,-0.0137962885,0.038528834,0.018776855,0.07697807,-0.069388814,-0.060039792,-0.02322719,0.03101788,-0.0342089,0.014526352,0.014950105,-0.06802138,0.023159701,-0.005194693,0.03631185,-0.030408083,0.04144054,-0.020623824,-0.027097031,-0.0045151664,-0.09275322,0.0029873394,-0.014734828,-0.028794006,-0.013327809,-0.025406165,0.070873745,0.019973593,-0.012229075,-0.094028756,0.081616715,0.10760328,0.06567325,-0.023410344,0.0076117762,0.015761083,0.011619779,-0.03926841,-0.024421284,-0.07231048,-0.036861926,0.02421238,-0.18368737,0.08247458,0.049580425,-0.0051191426,0.05008953,0.019591328,-0.031784583,-0.020484755,-0.015610679,-0.021573259,-0.07249377,0.03839055,0.027890032,0.07562151,-0.014550427,-0.0332802,-0.008204139,0.030511001,0.062477365,-0.0036963655,-0.030310636,0.07611128,0.005201311,-0.004498555,-0.03524737,-0.03652222,-0.0055160457,0.04064826,0.0670149,0.049508058,-0.0015046564,0.053652387,-0.1291295,-4.9607983e-34,0.0049508195,0.06803324,0.009010529,-0.012681551,-0.058995802,-0.00897301,-0.07971516,0.06624957,-0.05716854,-0.008931824,-0.09612917,-0.086685784,0.054040916,-0.018488757,-0.04723979,-0.043673024,-0.008626867,-0.010021693,0.002493252,0.027280135,-0.01922368,0.07031042,0.028196556,-0.027389862,0.06695252,0.0088470625,-0.031063067,0.033194922,0.12818621,0.03926041,-0.021055281,-0.07171512,-0.04341492,8.034788e-05,0.03801718,0.023698088,-0.105333544,-0.034327257,-0.054410987,-0.0017037011,0.057770237,0.041884772,-0.05118975,-0.072762564,0.02264826,0.03380078,0.021382444,0.052044336,0.002866813,0.059921045,0.013926178,-0.019761756,0.066866234,-0.042548575,-0.057666104,0.010566335,0.01057794,-0.044254564,-0.004749582,0.05539363,-0.0061445357,0.06813268,-0.0632985,0.04687058,0.039837293,0.080130905,-0.02624526,-6.9787566e-05,-0.034037206,0.11271,-0.015721193,0.0057817386,0.027523562,0.044928946,0.055720545,-0.0202918,-0.012492187,-0.036833417,0.11524942,-0.009724163,0.003305097,-0.012451384,0.04781722,0.025797034,-0.06917301,-0.101584256,0.017301474,-0.03765653,0.044066288,0.07149567,0.046909705,-0.067914285,0.065318145,0.043374546,-0.011700258,7.5106e-36,0.057099964,-0.06506549,-0.015705138,-0.08714034,0.009309783,0.06464975,0.07242809,-0.03903743,-0.014346412,-0.014146155,0.14671491,0.04213551,-0.09115122,0.005571264,0.013601965,0.008179584,-0.0063750036,0.047247987,-0.028571285,-0.03996512,-0.06284673,0.03757921,0.042425327,-0.012109443,0.034052677,0.016344415,0.06609757,0.056333143,0.05409712,0.04086845,-0.07989289,-0.02350271,0.011075318,-0.027847486,-0.020325292,0.050190873,-0.016429123,-0.00522329,0.03176165,-0.04700078,-0.015753126,0.036485795,0.027943758,0.019612702,0.016549299,0.10377883,-0.026482305,-0.019368647,-0.01111588,-0.027356496,0.02270787,-0.04419307,-0.022594698,-0.026983181,-0.04978729,0.034291115,0.035958026,0.015864702,0.023553953,-0.01899501,-0.032159396,-0.03422648,-0.000743789,0.07911014,0.0020800277,-0.018685829,-0.026187006,0.004155257,-0.014677371,-0.019047868,0.03724175,-0.063233756,0.08210544,0.08544692,0.062280692,-0.022704298,-0.09064865,-0.051546287,-0.055371266,-0.040231653,0.021708513,-0.020503353,-0.016181549,0.0082679,-0.012309211,-0.09687852,-0.06608122,0.10458736,0.078674145,0.031801652,-0.04743784,0.052395746,-0.044266254,0.05421833,0.10050988,-2.4387532e-08,0.003834569,-0.01983631,0.02962316,-0.0518335,0.017940871,0.13009255,0.002318971,-0.039755248,0.03522733,0.03293627,0.0005625768,0.11802266,-0.035987277,0.040552188,-0.10205303,0.0059166765,-0.05025528,-0.0147515945,-0.006686194,-0.014748114,-0.1462575,0.010682423,-0.07376131,0.0019985156,-0.050657112,-0.08013499,0.0075394376,0.07661138,-0.026025508,-0.11519854,0.052361198,0.06325728,-0.027843535,-0.041523457,-0.123093754,0.03600475,0.027862895,0.06673654,-0.0067625465,0.124812156,0.033303488,0.017378753,-0.034911692,-0.0038303141,0.09730425,0.042280495,-0.008525181,0.033044416,-0.009094766,0.03157355,0.01639935,-0.049009606,-0.031418942,-0.03254916,-0.06809197,-0.043374717,-0.05880032,-0.0583686,-0.0064446474,-0.09715081,0.0046616904,-0.026049651,0.18631205,-0.046621263 +6.3.2.33,"This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1].",384,1.0,-0.01032565,0.007363749,-0.12202793,-0.06158925,0.03540494,0.024186473,0.00455738,0.03342082,0.032705013,0.031101678,-0.026546584,-0.050095044,-0.09547147,-0.0033916885,-0.100310765,0.01762892,-0.06575518,-0.0010966138,0.04296857,-0.08818453,-0.014120664,0.022245448,0.01926341,0.011215384,0.018384254,0.007011933,0.032051023,-0.008135178,0.022346962,0.054127056,-0.069590956,-0.016722891,-0.045848884,-0.013452218,0.02662217,0.11693548,-0.07745135,0.0043570693,0.017658483,0.017477455,0.043720067,-0.052592363,-0.06884642,-0.011373362,-0.028726926,-0.017929144,-0.011089855,0.036305387,0.018106544,-0.008231651,-0.009294287,-0.09859508,-0.050850198,0.06310486,0.077071235,-0.043867335,-0.05155373,0.008828658,0.053706106,0.04541844,0.03429434,-0.029784821,0.050373383,-0.011985915,0.06996983,-0.07796598,0.012671917,-0.026973115,0.03453001,-0.039792083,-0.047200136,0.0027469697,0.0052744984,0.009655002,-0.081228495,0.016273765,-0.032597,-0.027182512,0.042495467,-0.034864563,0.06563154,0.050906338,0.011860799,0.093121074,0.06714267,-0.07880716,-0.0059189443,0.035261054,0.073482685,0.0368977,0.044919662,0.035571724,0.025727501,-0.07201784,-0.07727872,0.010547085,0.0028895247,-0.031482138,-0.028843611,0.01823184,0.003447825,0.06468184,-0.04691483,-0.029805467,-0.06246367,0.020812515,-0.052492343,0.056863423,0.024216998,0.014524556,-0.020794926,0.017365808,0.07248572,-0.012723881,-0.014808496,0.12111276,-0.0477756,-0.046796158,0.013084046,0.028188659,0.028431604,-0.0185014,0.029534223,0.118906245,-0.05113939,0.045509666,-0.06577529,2.8140123e-33,0.071555816,0.019560665,0.03279899,-0.02758803,0.052342396,-0.028749188,-0.0487148,0.012284418,-0.0066670845,-0.012063777,-0.067881055,-0.12823077,0.03108032,-0.017272208,0.022633381,0.00086412433,-0.052287288,0.00042220493,0.038612776,0.029212564,-0.03872352,0.05734117,-0.04940707,0.01078168,0.048874415,0.13266915,-0.10714383,0.011102311,0.07326447,-0.0038922299,-0.020913757,-0.058638785,-0.12930655,0.042321794,0.03493455,-0.08886539,-0.028925532,-0.041222643,0.01942888,0.051961336,0.0019172332,-0.048777565,0.026239688,-0.02239943,0.08449559,0.0142317545,0.030387932,0.017793674,0.047987796,0.030469116,0.06039838,-0.014057866,0.054072686,-0.02713479,-0.10909912,0.010325306,-0.037233565,0.014597185,0.05039705,0.06505412,0.00071061065,0.00065675646,-0.009210395,0.01826537,-0.053842958,-0.02371332,-0.052802503,-0.100279905,0.038391367,0.08228669,-0.066953816,0.048276313,0.069263995,0.009306481,0.05760721,-0.016480941,0.002148252,0.013783116,-0.043400634,0.003976031,-0.00402612,-0.015342288,0.011682437,-0.01585886,-0.03905902,0.031188626,-0.049168795,-0.065057695,-0.024035987,0.048610236,0.0016737214,-0.04616683,-0.09153943,0.033834048,-0.036310725,-3.0106941e-33,0.07882466,-0.09201136,0.061607562,-0.13021545,-0.079632595,0.09058833,-0.041827448,-0.06623596,-0.016332595,-0.07493809,0.09660605,-0.0173153,0.03901293,-0.012205773,0.011676795,0.010608264,-0.027510423,0.15752481,-0.009274019,-0.06434595,0.07767673,0.046727616,-0.048569925,-0.0009589785,0.08859843,0.008985661,-0.0038852582,0.06807258,0.09583665,0.060684897,-0.027989004,-0.022634577,-0.066508055,0.032001924,-0.036875907,0.015749954,-0.04276308,-0.0014387318,0.021366874,0.0738258,0.032645974,0.060753047,0.05851419,0.041324787,-0.005289006,0.056346126,-0.04085631,0.05844315,0.056312654,-0.05574275,0.096232325,-0.019347845,-0.06776221,0.017050797,0.047050737,0.06330049,0.03791624,-0.0363964,-0.0056829765,-0.022692142,0.013986367,-0.07055586,0.062360622,-0.029680625,0.03278046,0.08688656,-0.020087866,0.085019596,0.045677304,0.011157822,0.057324808,0.015841657,-0.009039086,0.009866115,0.015643457,-0.03494802,0.030853665,0.04566845,0.045313053,-0.035621088,-0.034583364,0.060036592,0.043523192,-0.05486809,-0.023616076,-0.006222963,0.0564602,0.08753369,0.063302055,0.047753565,-0.01002249,0.034089092,-0.07317983,0.032387257,0.0067609427,-3.7352645e-08,0.09125271,-0.15204033,-0.010239854,-0.11391676,0.05551558,0.017816616,0.0011837196,-0.009096629,-0.012191878,-0.06730208,0.015686246,0.0053981445,0.036679156,0.023896936,0.013508162,-0.039824624,-0.06789069,0.02059183,-0.03747761,-0.014171386,-0.075450756,-0.02935445,-0.076515086,0.053332087,-0.008283798,-0.07418895,0.001432831,0.059042305,-0.0050869724,-0.045319352,-0.00031614298,0.05082339,-0.036503058,-0.025519455,-0.057850406,0.057005275,-0.06485405,-0.038309574,-0.07000363,-0.012609585,-0.03856791,-0.07147824,-0.024299923,-0.0017404142,-0.039585315,-0.043429952,0.03256593,0.0060595195,0.0044729733,0.023975454,0.04790377,0.028800298,0.0136342775,-0.045915846,-0.045207556,-0.08389189,-0.031401873,-0.05846725,-0.069310546,-0.094880946,0.048632763,0.0035701704,0.178484,-0.030941555 +6.3.2.34,"This protein catalyses the successive addition of two glutamate residues to factor 420 (coenzyme F420) by two distinct and independent reactions. In the first reaction (EC 6.3.2.31, coenzyme F420-0:L-glutamate ligase) the enzyme attaches a glutamate via its alpha-amine group to F420-0. In the second reaction, which is described here, the enzyme catalyses the addition of a second L-glutamate residue to the gamma-carboxyl of the first glutamate.",384,0.99999994,0.007553671,-0.017068535,0.016180487,-0.029114973,0.039108638,0.045178507,-0.026115147,0.04900711,-0.026257686,0.010067427,0.08316151,-0.04577961,0.018846096,0.067746274,-0.0058305617,0.0015554302,-0.05932269,-0.042872325,-0.10156072,-0.08280283,0.074374035,0.029540827,-0.06900666,-0.07299128,0.052309997,0.077436246,0.06679271,-0.05258552,0.07133967,-0.05108273,-0.0019743242,-0.025761824,0.0363243,-0.008955554,0.006660659,-0.008548428,-0.07993399,-0.10632997,0.05960614,-0.0060497937,-0.012121145,0.101954214,0.0263599,-0.041563462,-0.0038386497,-0.0049612117,0.05757188,-0.022436215,0.02827005,-0.019688878,0.059922833,-0.0024828003,-0.0106620155,0.035851795,0.04566151,0.014976989,-0.0033425153,-0.028828064,-0.04698633,0.07330488,0.022120329,0.020748328,-0.01938077,-0.055834625,0.052901577,-0.019529967,0.04881641,-0.035492737,0.0019816693,-0.03668928,-0.041032895,-0.03326855,0.032042604,-0.0039920467,-0.006471369,-0.020178365,0.0030794006,-0.040969186,0.03170914,0.0015333912,0.08458713,-0.04377021,0.111080654,0.033779982,0.049264845,-0.03879322,-0.013634216,0.025741784,0.0428713,0.019079397,-0.0011214551,-0.026184876,-0.046280526,0.0044020577,-0.11984636,0.048531637,-0.021363124,-0.012076336,0.010486455,0.005980926,0.001377725,0.06117961,-0.003514646,-0.035120297,-0.027091611,0.04116881,0.0107614845,0.10011777,0.008196363,-0.012175248,0.034341678,0.015734406,0.05242441,0.0037898654,-0.022865018,0.046020832,0.012558838,-0.036334496,-0.018435644,0.016206706,0.062047366,0.007887587,0.022652093,0.01694553,-0.062337864,0.022589615,-0.16698709,3.8880945e-33,0.05813771,0.051276978,-0.05407485,0.008562871,0.055062175,-0.024667842,-0.05743784,0.07849518,-0.03553384,-0.00359988,-0.09949649,-0.09791287,0.038202833,-0.03773167,-0.045381416,-0.051324897,-0.0455248,-0.024130106,0.033866152,0.006039424,-0.035232358,0.08772741,0.002050357,-0.02195696,0.10211401,0.06360414,-0.0040975367,0.03847938,0.056469705,0.02343753,-0.043598987,-0.04759303,-0.14474276,-0.005483408,0.033922616,-0.028900905,-0.03046879,-0.06819177,-0.018390842,0.044801712,0.055240896,0.023783823,-0.10652565,-0.02307358,0.030671604,-0.05147689,-0.027768087,0.110879846,0.06110292,0.09453071,0.014969435,-0.019293122,0.04446771,-0.013583842,-0.06776067,0.00015026692,-0.068756305,-0.06732369,0.052514374,0.03158702,0.025235362,0.04067132,-0.07915951,0.06321395,0.037165705,0.029874472,-0.0012944574,-0.08289064,0.013933059,0.0613122,-0.048730053,-0.02524845,0.06769093,-0.026093403,0.02000374,-0.06121902,-0.026523529,-0.02876888,0.08903242,-0.006459497,-0.020163933,0.013590823,-0.012309042,-0.019482188,-0.0264735,-0.003640366,0.0029640375,-0.046350975,0.047935892,0.05546365,0.042437293,-0.053512137,0.06920393,0.030989029,0.008960774,-3.614127e-33,0.051742457,-0.07638544,-0.008724402,-0.07121195,-0.038101338,0.010995904,0.013977432,-0.086154535,0.005824164,-0.021046253,0.08895412,-0.016132746,0.032006633,-0.0077134185,0.016794346,-0.0145084,-0.036197167,0.077111304,-0.010888083,-0.021885589,0.042459138,0.07011319,0.06973135,0.016935805,0.05248929,0.03446021,0.042443134,-0.01676891,0.03099292,0.08269645,-0.020625232,-0.041346155,0.013378612,-0.05812583,-0.05394661,0.03985076,0.018370708,-0.017469803,-0.0010869526,-0.025924375,-0.009989379,0.11035158,0.021142347,0.016115153,-0.0028670945,0.054407835,-0.0027521842,-0.046321552,0.011823479,-0.117358536,0.05257921,-0.06853091,-0.07492378,-0.072765715,-0.10007513,0.0053901062,0.046653558,-0.035818953,0.036782455,-0.005688392,-0.017898329,-0.06184334,0.026557213,0.0012747156,0.097829945,0.04077806,0.012163433,0.01931541,0.054892477,-0.023712479,0.022910627,-0.034948252,0.03611541,0.12501103,0.01660184,0.01825315,-0.059647053,-0.024498709,-0.0056048576,-0.04864374,0.01911212,-0.022647997,-0.025257273,-0.025603198,-0.06417219,-0.16338228,-0.060771815,0.15850571,0.06447765,-0.0017678989,-0.08548209,0.04369216,0.011161384,0.10275887,0.0940855,-4.0577667e-08,-0.008963597,-0.06118791,-0.08360758,-0.013731365,0.031107796,0.08913402,-0.065884925,-0.042210422,0.07405484,-0.04338859,0.00211808,0.095287666,-0.0698965,0.054640077,-0.035972152,0.010231159,-0.044028845,-4.645439e-05,-0.027024835,-0.0012293485,-0.05347516,0.012566418,-0.042321827,0.010016796,0.0019719577,-0.0862631,-0.013481583,0.13161893,-0.04409647,-0.038416307,-0.055533182,0.07381624,-0.023155194,-0.049917117,-0.09533262,0.004679516,0.0641921,0.0034200079,-0.057209373,0.03183968,0.030394847,-0.06484199,-0.07385983,0.003193589,0.04361185,0.0007937501,0.052584328,-0.026835607,-0.038370855,-0.0203042,0.04786297,-0.028798556,0.012804968,0.04378945,-0.091215536,-0.045520972,-0.051647905,-0.037887484,0.016430587,-0.07502094,0.025452984,0.036143,0.14132655,-0.08183384 +1.1.99.34,"The enzyme is very specific for D-glucose 6-phosphate. No activity with NAD+, NADP+, flavin adenine dinucleotide and flavin mononucleotide [1]. 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The reaction is involved in the aerobic catabolism of nicotinic acid. ,384,0.99999994,-0.06104474,-0.028125284,-0.09704572,0.04177828,0.08261085,0.05656753,0.017246997,0.04466489,0.05548775,-0.043133616,-0.019454174,0.026165117,-0.08562867,-0.045760125,-0.07990902,-0.021181274,-0.036879417,0.039845318,-0.085767314,-0.01822771,-0.0073513943,0.0064762007,0.08492086,0.006262398,0.0040092138,0.0039393483,-0.021767547,-0.046748202,-0.02267579,0.025242347,0.079085365,0.07279086,0.051889915,0.022662882,-0.053103674,0.02702249,0.00040749722,-0.017638195,-0.020823505,0.00017881597,0.051931784,0.0066277394,0.0036968964,-0.0025900176,0.084988765,0.033760212,-0.026475368,-0.0023379761,-0.0025030165,0.052916516,-0.0047294116,-0.03521053,-0.07679311,-0.017117433,-0.008223863,0.0025269971,-0.034277353,-0.05359709,-0.025303783,0.026733533,0.01743599,-0.035847627,0.042754773,-0.0010815961,0.052083574,-0.12129101,-0.014772599,-0.018508187,0.08959144,-0.051910724,-0.029189467,-0.01671446,-0.049778216,0.002766934,-0.024845425,0.08866609,-0.077950925,-0.023752488,0.055199318,0.011382137,0.122355565,-0.055039063,0.059707243,0.1257817,0.030370736,-0.012734445,0.0066788546,0.0031721715,0.00022399581,0.073483594,-0.05339936,0.048129465,0.016801642,0.034756273,-0.13045861,0.01336634,0.038682908,-0.02191504,-0.086569175,-0.0036870942,-0.027775122,0.04109198,0.087931454,0.010805393,-0.07406652,-0.07258897,-0.0016069564,0.03226995,0.02926958,-0.05387449,0.022902094,-0.019054338,0.020170268,-0.080078095,0.043682117,0.06312376,-0.001941788,-0.05475276,-0.023062035,-0.027836824,-0.05500261,0.055505194,0.04494125,0.03704883,-0.003972795,-0.06411831,-0.08715598,-3.2688438e-34,0.047167975,-0.009956258,0.009285813,0.014784991,0.03588745,-0.0236875,-0.07444994,-0.04706075,0.07723581,-0.038919333,-0.038323846,-0.033136193,0.04854566,-0.0008721223,0.022918517,-0.0058452548,-0.051295538,-0.07322686,0.09244608,-0.11482859,0.041245233,0.063015245,-0.0075802333,0.06460873,0.015154327,-0.018421497,-0.09658716,-0.0015982054,-0.0062507116,0.024489632,0.0024649168,-0.014609137,-0.07891785,-0.046129905,-0.03563884,0.06407127,-0.04861582,-0.03496354,-0.059943043,0.07599734,0.019117748,-0.03070013,0.005066733,-0.024885887,-0.0029657737,-0.038667623,-0.09435432,0.119066685,0.05174144,0.10049743,0.019117726,-0.08639704,0.15708952,0.049078383,-0.084350355,0.03379568,0.0022734583,0.0021942728,-0.038677678,0.045502275,0.01876763,0.038989782,-0.024386853,0.12688646,-0.08683082,-0.012245689,-0.037551355,-0.07263243,0.04988026,0.09010627,0.013360426,-0.0015434194,0.0921728,-0.024409592,0.07994185,-0.06410045,-0.069851086,0.00013652274,-0.08528891,0.08304533,0.0011977615,-0.037810303,-0.060335316,-0.026577411,-0.06228975,0.046733443,0.026112217,-0.030142961,0.04777823,0.03374086,-0.024968103,-0.031904418,0.03371449,0.048456836,0.05287131,2.0592583e-34,0.06021017,-0.073835075,0.04389989,0.03109095,0.043163832,0.04696816,0.06689063,-0.026654476,-0.051249497,-0.04263098,-0.0013541571,-0.09677669,0.0054449476,0.06314661,0.041919354,0.03365299,-0.05909609,0.014925244,0.047373094,0.06462613,-0.06127776,-0.02402043,0.037209492,0.070763744,0.06916719,0.0035682204,0.038182613,-0.03953836,0.010629168,-0.015559462,-0.0285405,0.02796144,-0.057226937,-0.01366321,-0.032985978,0.034015913,0.005728749,0.005279691,-0.044442147,-0.023675822,-0.0025972577,0.009241521,-0.017813116,0.062244684,0.093774706,0.01381846,-0.018603249,-0.0014053514,0.0039063515,-0.043820065,0.05710719,0.03290792,-0.06087223,0.109795816,0.10441367,0.08583378,0.02196113,0.06121949,-0.035509594,-0.02849543,-0.002312128,-0.09644868,-0.021079443,-0.0321203,0.08719782,0.0792412,0.040350646,0.11903918,0.014373735,-0.028777761,0.10264282,0.022254802,0.058897436,0.08875594,0.03609979,-0.061323803,-0.008181046,0.045845058,-0.021969859,-0.009469514,-0.032640364,0.022247244,-0.006905468,-0.02532237,-0.09067567,-0.08652267,-0.026839383,0.06745749,-0.025459599,0.01636711,0.009717536,-0.007664639,-0.018104874,-0.04317431,0.027899561,-2.4898918e-08,0.03211985,-0.06833575,0.01636536,0.011778016,0.05866799,0.049019363,-0.006609018,-0.029583935,-0.035444733,-0.031090397,0.0075151934,0.10893196,0.028551642,0.0488449,0.024792802,-0.015944157,-0.03530225,0.027803749,-0.00547734,-0.014130855,-0.12335527,0.040626734,-0.05187215,0.006764054,-0.057406574,-0.05352127,-0.06534443,0.008824922,0.042884815,-0.06939747,0.039604425,0.0175799,0.046348896,-0.088528216,-0.10664759,-0.0047407253,0.07609062,-0.09664417,-0.031097522,0.01620364,-0.087191544,-0.022659011,-0.014478711,-0.028240012,0.012716735,-0.03592797,0.01952064,-0.01492802,-0.0387721,-0.028166594,-0.00324555,0.017143596,0.025565159,0.0040425295,-0.095564,-0.019864742,-0.009851416,-0.04162537,-0.018879894,-0.07858051,0.031482905,0.0028924628,0.07998595,-0.0007123768 +3.5.1.104,"Modification of peptidoglycan by N-deacetylation is an important factor in virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis [4-6]. The enzyme from Streptococcus pneumoniae is a metalloenzyme using a His-His-Asp zinc-binding triad with a nearby aspartic acid and histidine acting as the catalytic base and acid, respectively [3]. 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Besides being a nutrient, the heterodisaccharide product 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a unique inducer of chitinase production in Vibrio parahemolyticus [2]. In contrast to EC 3.5.1.41 (chitin deacetylase) this enzyme is specific for the chitin disaccharide [1,3]. It also deacetylates the chitin trisaccharide with lower efficiency [3]. No activity with higher polymers of GlcNAc [1,3]. 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+3.5.1.106,The reaction is involved in the aerobic catabolism of nicotinic acid. 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+3.5.1.107,The reaction is involved in the aerobic catabolism of nicotinic acid. ,384,0.99999994,-0.026235882,0.03580692,-0.045469828,0.043918252,0.013702647,0.101315565,-0.018668698,0.020269495,0.049651667,-0.00355679,-0.019720409,-0.021310432,-0.04749165,-0.042025384,-0.05533688,-0.044544816,-0.012919243,0.10348707,-0.06809506,-0.030411048,0.06160156,0.009899979,0.07647442,0.027019944,-0.0074743684,0.035993993,-0.059717167,-0.011903388,-0.021229606,0.005991574,0.009889495,0.007993336,0.025000414,0.0127605535,-0.038585786,0.013174541,-0.07668301,-0.008847901,0.004818016,-0.0019456366,0.036071762,0.02681554,-0.06445171,-0.01652728,0.037747625,0.030565731,0.023058621,-0.10575911,0.023653565,0.022926588,-0.025413873,-0.013290755,-0.0065146475,-0.06434248,-0.021546656,-0.050178472,-0.052022565,-0.0075111245,-0.027512953,-0.012582395,0.054198176,-0.011091147,-0.015953682,-0.0012394215,0.018513553,-0.13026404,0.054949857,-0.024892872,0.07382536,-0.057899434,-0.07625361,-0.022394514,0.0027432723,-0.042173102,-0.048558228,0.073575824,-0.047197893,-0.03538502,-0.01204017,0.0227259,0.099921174,-0.044560988,-0.038627706,0.12256396,-0.016421642,0.050970193,0.006802869,-0.0054845233,0.023092305,0.048544317,-0.040488586,0.040033143,0.029023523,0.014402493,-0.12593648,-0.06155702,0.004195495,0.064517885,-0.013892529,-0.0014311669,0.0103202555,0.09419443,0.072357155,-0.03970521,-0.041944463,-0.019924646,0.013241978,0.010294535,0.08497674,-0.018988814,0.031361733,-0.009239711,-0.039980862,0.0025105234,0.03827095,0.15425828,0.037299216,-0.055464085,-0.054702785,-0.021155445,-0.0024640472,-0.06730565,0.033100113,-0.022799946,-0.06581474,-0.08000573,-0.038426086,-2.4711037e-33,0.0146362325,-0.0019945204,0.050972868,0.014552997,0.045792893,-0.02943461,-0.09872073,-0.05102938,0.07097649,-0.039665494,-0.025747845,-0.06878079,0.06431309,0.06539869,-0.041055232,-0.024123274,-0.05091448,-0.056072,0.0658644,-0.015070422,0.025435597,0.0464934,-0.025202852,0.05774462,-0.01596296,-0.010291092,-0.07270281,-0.023905553,-0.02791519,-0.027983332,0.03865074,0.010542098,-0.08560436,-0.048999332,0.028960753,0.06285825,0.0076707094,0.06893091,0.028008642,0.05948179,0.019238325,0.007302474,0.030654304,-0.04321616,0.014315013,-0.027207395,-0.07514788,0.11508295,0.13049822,0.07407853,0.031339936,-0.07514404,0.14963333,-0.04229152,-0.023232667,0.05485986,0.044693746,-0.0092652505,-0.05670912,0.10480849,0.024359766,0.006234282,-0.028681846,0.12005027,-0.029455408,0.0021373932,-0.07486619,-0.07311888,0.07313593,0.016353732,-0.069283485,0.0332679,0.056039587,-0.021430016,0.053772513,-0.052928276,-0.10582215,0.049463615,-0.061499953,0.069411114,0.03133341,-0.062464878,-0.071033455,-0.00528328,-0.077532776,0.040326864,0.04434208,-0.016574342,0.06366437,0.053565353,-0.043103807,-0.016830122,-0.0023631994,0.027912796,0.04450337,-1.7403836e-34,0.1007519,-0.021864165,0.018791838,-0.02519434,0.048264243,0.08371381,0.05586976,-0.0102144545,-0.12799889,-0.0050825956,0.006453917,-0.04463132,0.031606592,0.083067015,-0.009905691,0.017243106,-0.027493482,0.021481454,-0.0038198296,0.053540003,-0.029662888,0.042267963,-0.0012307807,0.022351021,0.084702484,0.0015697043,0.014327203,0.016891142,0.023739181,-0.04144527,0.014606897,-0.005872404,-0.039962053,-0.036628503,0.03298724,0.047611043,-0.0021505607,0.008335509,-0.0339231,-0.07487027,0.016531974,-0.031889167,-0.00020378381,0.045169625,0.09865762,-0.016219765,-0.04688366,-0.08140957,-0.0768402,-0.024720764,0.07188965,0.025431044,-0.104075186,0.06772225,0.109669216,0.09597499,-0.038373455,-0.007050417,-0.027236452,-0.058207057,-0.03015158,-0.0139939375,-0.020569047,-0.075432025,0.024063975,0.046697613,-0.008858885,0.06456542,0.07185934,-0.08945442,0.054300003,0.041092444,0.073098175,0.06345363,-0.011275303,-0.069113225,-0.025696166,-0.041029967,-0.029782599,-0.060739625,-0.09715229,0.03937434,-0.003222717,-0.0963219,-0.047728088,-0.027400136,-0.047669463,0.06304927,-0.051824965,-0.026560562,0.052461125,-0.09079598,-0.026878282,0.02493326,-0.00054344634,-2.2143308e-08,0.030998267,-0.056788333,0.046765674,0.047015984,-0.042918086,0.043965966,0.05990987,-0.014491684,-0.01871733,-0.037615877,0.06261617,0.083899826,0.06990007,0.109648466,-0.02330096,0.0381754,-0.076020636,0.0236037,0.0055563343,0.008276882,-0.12737899,-0.011118407,-0.037358616,0.010583047,0.013195218,-0.07598382,-0.08340368,0.043305498,-0.0058491416,-0.09656063,0.040679302,-0.015288448,0.04026641,-0.08586212,-0.035251264,-0.04906671,0.0498808,-0.04727976,0.0017954619,-0.055842012,-0.042500507,-0.020040028,-0.06549368,0.029057609,0.049438316,-0.04473479,-0.014676531,0.0025941427,-0.008544413,-0.01477334,0.006825346,0.04402083,0.029891158,-0.0034907712,-0.0954477,0.0034537506,0.019696407,-0.0064509064,-0.011639262,-0.042259846,0.05754986,-0.021452779,0.06450017,-0.024327137 +1.1.1.305,The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).,384,1.0,-0.060882762,0.0006665369,-0.025646275,-0.035959654,-0.01451782,0.046871923,-0.044108856,0.06029004,0.07456525,-6.345142e-05,0.080605686,-0.06919737,-0.087949105,0.0028564204,0.0036543137,0.07313046,-0.07014587,0.0050752666,-0.019300489,-0.049146146,0.014866521,0.01608202,-0.023113951,-0.003192915,0.03438804,0.0005967269,0.060785268,-0.013003839,-9.362607e-05,-0.08298569,0.05628301,-0.047347963,0.051701345,-0.0587179,0.055086,0.11374095,-0.0073119877,-0.11976943,0.0508085,-0.02889367,0.0660624,0.004578454,0.002773661,-0.06110329,0.019456815,-0.055529505,0.04863191,0.0066302223,0.06011325,-0.009090341,0.04195321,-0.026529878,0.00042514515,-0.004086205,0.024301764,-0.03569636,-0.08413057,0.010232607,-0.02136174,0.008370105,0.045689326,0.014013173,0.006332732,-0.004413239,-0.02657934,-0.029259533,0.09780807,-0.11331401,0.011524785,-0.049752355,-0.080952056,-0.04789422,-0.060336974,-0.011169638,-0.010207523,-0.016693663,-0.043009747,-0.0729424,0.031021114,-0.028530648,0.03900586,-0.049861617,-0.011186807,-0.0071416814,-0.0021621913,-0.022057926,0.04262968,-0.028604075,-0.004908242,0.04018494,0.002744311,-0.021352604,0.007987284,0.011090068,-0.007829528,0.01841261,-0.0037743102,0.10261275,0.084294006,0.0045392103,-0.008399001,0.1206729,-0.074789174,-0.10982021,-0.040683016,-0.008379738,0.023546552,0.061840825,0.024325369,-0.034929927,-0.0047966763,-0.08710688,0.055449743,0.06244102,-0.009794022,0.13927753,0.0016404026,-0.08562607,-0.001059051,0.026860414,0.0778015,-0.049528964,0.08950039,0.073333785,-0.04538511,0.026824167,-0.08803687,-1.45484085e-33,0.09142109,-0.0058409795,0.036984637,0.0075827977,-0.03374812,-0.012338158,-0.08526295,0.06126665,-0.0659157,-0.07380216,-0.079761155,-0.066243656,0.11502949,0.09349834,-0.03976783,-0.06917597,0.045487233,-0.045103177,0.07222467,0.016018618,0.0059425947,0.017926266,-0.00030196164,0.031320564,0.024952974,0.035287187,-0.006387204,0.034082707,0.010638379,0.017084492,-0.050018862,-0.10200358,-0.1444862,0.01217691,0.016583076,-0.030439837,-0.02190483,-0.027443588,0.007789968,-0.010951449,0.005520137,-0.023747114,0.018362166,-0.054063376,0.089475885,0.03441889,-0.015152972,0.11010588,0.06801918,0.052488018,0.039242882,-0.019888008,0.09357089,-0.0526209,0.021922482,0.052736096,-0.055325326,-0.00969612,0.0029379064,0.10600887,0.019585604,0.09540737,-0.051026184,0.033416208,-0.020357467,0.029984945,-0.033804458,-0.06052343,-0.022239896,0.0121834455,-0.031022733,0.026513388,0.097558364,0.008662333,0.06327848,-0.023510655,-0.06286605,0.0093706185,0.03627007,0.06621055,-0.06962138,0.043086678,0.020431528,-0.055582978,-0.048685566,-0.006227209,-0.0076174187,-0.015967702,0.0016453891,0.07051287,-0.01896852,-0.008677907,-0.10755049,0.014057964,0.05732535,-1.0709989e-33,0.034032978,-0.042441666,-0.093187936,-0.08520193,-0.05447905,0.023266174,0.08832036,0.02069812,0.09033281,0.060745835,0.08773692,-0.06526194,0.05303886,-0.11564043,0.05502794,-0.005915746,-0.07936861,0.052959055,-0.010969425,0.02899093,-0.011442412,0.05888597,-0.0036908982,0.020287681,0.06868959,-0.0060807355,0.02408461,0.07592138,0.03666339,0.03403646,-0.04432905,-0.0015470017,-0.072348736,0.012523337,-0.045457583,0.047298018,-0.012083223,-0.007142857,0.011364573,-0.033633795,0.004692022,0.06259689,-0.00078251195,0.06199113,0.055342086,0.084712744,-0.029067745,0.01534115,-0.08172307,-0.08561028,-0.0021800231,0.011820042,-0.01829058,0.046016853,0.01949382,0.0884055,0.011467277,0.01940966,-0.003778557,0.0083214035,-0.015543604,-0.07805577,0.09226705,-0.028399738,-0.00021250299,-0.01375646,-0.053826395,-0.018124942,0.04118019,0.012002639,0.09057631,-0.053843223,-0.04334317,0.009295473,-0.026842108,0.0028325114,-0.11350107,-0.085517734,0.01212776,-0.06021271,-0.012406932,-0.034405194,-0.020377958,-0.062100224,0.022198977,-0.06163697,0.014633501,0.0795047,-0.03902243,0.030116392,-0.036372792,-0.033854835,-0.057919428,0.09328568,-0.019517278,-3.223604e-08,0.01062381,-0.021420622,0.081097715,-0.05977446,0.015008323,0.046228185,0.024835562,0.055147972,-0.023895824,-0.03546832,-0.026989285,0.032368567,-0.0060826624,-0.03184977,0.01339324,0.022953687,-0.0011124916,0.044450812,-0.028082494,-0.066708215,0.029555932,-0.05056101,-0.112500876,0.020442793,-0.02364322,-0.07430465,0.01632937,0.059429847,0.012492845,-0.08135848,0.014170382,0.022756156,0.015002471,-0.072223395,-0.07263558,-0.0012354756,-0.0069313347,-0.030723426,-0.014900439,0.106571436,-0.017419698,-0.07913801,-0.081825085,-0.0054696626,0.015177113,0.026610525,0.014616136,0.0076863035,-0.040974207,0.03208107,0.08379434,-0.06185376,-0.024902299,0.015395716,-0.01853024,0.016091479,-0.03664281,-0.095769204,0.030483358,0.00397013,-0.001717183,0.07373905,0.13203521,-0.02821875 +1.1.1.306,"S-hydroxymethylmycothiol is believed to form spontaneously from formaldehyde and mycothiol. This enzyme oxidizes the product of this spontaneous reaction to S-formylmycothiol, in a reaction that is analogous to EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase.",384,1.0,-0.0063745305,-0.03293833,-0.04702143,-0.0013701427,0.114074074,-0.0005759907,-0.07476317,0.059076056,0.011505388,-0.009480675,0.06888678,-0.058245566,0.02116644,0.017801052,-0.028562611,0.018817965,-0.048289385,-0.019202618,-0.038737904,-0.012678289,0.009727368,0.03987057,-0.06691691,0.06190909,0.08757244,-0.06670401,0.044406317,0.027209744,-0.07160553,-0.080219656,0.035193887,-0.013332358,0.020446414,-0.018372983,0.074165985,0.06728719,-0.046021387,0.01182302,0.05037289,4.4049644e-05,-0.03682473,-0.10473019,0.011821471,-0.042123087,-0.011008728,0.013772385,-0.03880068,0.069829114,-0.04262849,-0.014700902,0.0011219305,-0.031674348,0.008821859,-0.0014672136,0.03136176,-0.01357222,0.04894186,-0.06592804,-0.08276716,0.04182227,0.011085402,-0.043141775,-0.07273733,-0.04987973,0.018174434,-0.013326792,0.038305197,-0.09339791,0.11156452,-0.022869214,-0.060420472,-0.074588515,-0.045445446,0.076965496,-0.04368542,-0.039709933,-0.053032864,-0.050847188,0.109074526,-0.0019421624,0.044625748,-0.0022435493,0.022546964,0.06062798,0.03783162,-0.04600237,-0.023156244,-0.0008968563,0.037741166,0.06223134,-0.04182234,-0.05555097,-0.052887283,-3.18159e-05,-0.05352611,0.070412636,0.050021626,0.05150152,0.049425513,-0.030735428,-0.007865957,-0.016386965,-0.114848085,-0.047000032,-0.008488355,0.00659463,0.021471474,0.06689727,0.03899236,-0.010263791,0.046514492,-0.04323966,-0.0051987516,-0.01789806,-0.03000907,0.08826218,0.08999165,-0.010665345,-0.08907564,-0.024588808,0.034675322,0.07156166,-0.006868992,-0.0329253,-0.0649391,0.00800833,-0.023748713,1.6965306e-33,0.068308026,0.04614025,-0.05611479,0.03266398,0.019456731,-0.03880167,-0.09476768,0.059960578,0.03558761,-0.039160013,-0.09171424,-0.01203338,-0.052033428,-0.03977195,-0.10152281,0.020842839,-0.055045854,-0.035415072,0.040558174,0.038170736,0.009941457,0.024516527,-0.034101527,-0.037627343,0.009930104,0.013141992,-0.029468253,-0.0173334,0.03145863,0.040626127,0.009224552,-0.04947909,-0.09195886,0.027386032,0.030351603,-0.033889912,-0.031013992,-0.0486384,0.06559731,0.017055439,0.016117977,0.05437748,0.020167986,-0.073532656,0.020899577,0.036731694,-0.03963034,0.12078155,0.0132445255,0.04058483,0.029471787,-0.022006428,0.09732224,-0.022474112,-0.053330597,0.015221027,0.026220756,-0.06414642,0.038930476,0.11250185,-0.03542898,0.14187016,-0.04086099,0.019160686,0.014744114,-0.06815096,0.0036542914,-0.014840928,-0.011196572,-0.02625962,-0.00010014644,0.052702572,0.013011246,-0.030924644,-0.0077467873,-0.06334471,-0.04323892,0.046973336,-0.013912717,0.022133242,0.020983892,0.053783465,-0.019558242,-0.028405102,-0.021783892,0.019702831,-0.013243744,-0.015162805,-0.010109202,0.037662547,-0.00462565,-0.07405694,0.048551742,0.008954246,0.04615866,-2.9565791e-33,0.04083086,-0.065888666,0.00542624,-0.03367987,0.006477975,0.09100479,-0.01437352,0.057125315,0.07965101,0.06565574,0.08212783,0.033912003,-0.038570233,-0.046270005,0.031746794,-0.04477897,-0.02716027,0.07654027,0.01028979,-0.033923183,0.012447091,0.09504284,-0.038736135,0.041953735,0.10455445,-0.022938214,0.011876003,0.06959381,0.04811559,0.12716968,-0.0016597656,-0.0022098364,0.0121460995,-0.023239253,0.053444836,0.04193154,-0.11167328,0.05342143,0.0311824,-0.0313236,-0.036069307,0.031641856,0.028005058,0.07306281,0.047925696,0.04556426,-0.14917572,-0.023363043,0.042072847,-0.0548848,0.0053099245,-0.022463767,-0.040297765,-0.03067522,-0.033871558,0.019700473,-0.012936965,-0.011581757,-0.03317426,-0.027686417,-0.043345407,-0.04495717,-0.066785604,0.0011704144,-0.023668889,0.047115795,-0.030570112,0.00041566696,0.093546145,-0.0059463726,0.05408528,0.00022178875,-0.019097539,0.063314356,-0.013473954,-0.029656202,-0.013892963,0.030763002,0.017542282,-0.009923143,0.099187486,0.051091626,0.05245002,-0.09445372,0.0011226343,-0.16455114,0.005975339,0.13156503,-0.041326664,0.053494357,-0.011037554,0.07325588,-0.042065974,0.029375624,0.047250185,-3.6304904e-08,-0.010758838,-0.04593083,0.09472358,-0.0021171586,0.014553618,0.030427352,0.08242307,-0.015479957,0.10566089,-0.07352796,-0.033059508,0.10328341,0.039810825,-0.0028894276,0.0019407786,-0.052251447,0.008910895,0.055458803,-0.03281812,0.0060585216,-0.045873143,-0.012814223,-0.081158794,-0.049417607,-0.02646582,-0.010461911,0.014874374,0.013425828,0.03159192,0.014996985,0.044615403,0.027398856,-0.06493701,0.0091640195,-0.18861307,-0.00043485165,-0.08400101,-0.042568494,0.04021285,-0.0684595,-0.012855785,-0.049668055,-0.051760096,0.008526189,0.0083311675,-0.020190641,-0.014907447,-0.016559636,-0.007302683,0.07624071,0.05117558,-0.02543119,-0.004238072,-0.012310277,-0.05468049,0.0017472355,0.030095058,-0.068005875,-0.03289284,-0.11911677,0.024595015,0.03037552,0.16606693,0.02700102 +1.1.2.6,"A quinoprotein. The enzyme is involved in bacterial polyvinyl alcohol degradation. Some Gram-negative bacteria degrade polyvinyl alcohol by importing it into the periplasmic space, where it is oxidized by polyvinyl alcohol dehydrogenase, an enzyme that is coupled to the respiratory chain via cytochrome c. The enzyme contains a pyrroloquinoline quinone cofactor.",384,1.0,-0.059956294,-0.023005554,0.0020124877,-0.04916561,0.087760076,-0.019375235,0.025855279,0.06800199,0.029138597,0.031872872,0.03578226,0.00741223,-0.05506993,0.09072191,-0.047768112,0.08902907,-0.11461793,0.0018802106,0.012882636,-0.04152931,-0.014679901,-0.023981761,-0.0708729,-0.02106165,0.02715494,0.008112723,0.04169111,0.038403273,-0.054195,0.018208206,-0.013615666,0.053372424,0.025000004,-0.0080786105,0.0257266,0.12363037,-0.013043558,-0.0065795993,0.047866702,0.004003367,0.040197697,0.07821054,-0.03658666,0.019026568,0.03390037,0.082973056,-0.022494186,0.10058807,-0.0066462387,0.031716418,-0.07473652,-0.026326986,-0.022303736,0.0496245,0.03356074,0.04754633,0.03341566,-0.05594322,-0.05427151,0.042851467,0.006065406,0.00933698,-0.0134053435,-0.0035975308,0.02713251,-0.030404069,0.04191052,0.013489652,0.0031884625,0.02189165,-0.055356942,-0.056122094,-0.00012989236,-0.015540912,-0.016188152,-0.025958927,-0.055224415,-0.04440124,0.0116741145,-0.03322155,0.040955897,0.033487853,-0.0008581858,0.07557742,0.059915468,-0.042705446,0.06275154,-0.08333458,-0.0070762974,0.040614873,-0.044234402,-0.062434375,-0.018286966,-0.15418345,-0.038689528,0.060491662,-0.0070785703,-0.029629141,0.036196787,0.021711634,-0.037450366,-0.0045389803,0.0067039086,-0.13528386,-0.08838001,0.024549184,-0.009551605,0.044456795,0.084203385,0.05187469,-0.07844675,0.016470315,0.042584043,-0.044426825,0.006682736,0.08224213,0.10420532,-0.002314356,-0.031526916,-0.01903741,-0.052738085,-0.010981793,0.044441547,0.022970881,-0.020157114,0.0017249566,-0.043469205,3.6361622e-33,-0.011931133,-0.055646233,-0.025250917,0.042383187,-0.006228066,-0.051529124,-0.030499741,0.027353343,-0.07027032,-0.08007018,-0.020767594,-0.06460973,0.0022328198,0.015895797,0.0009843142,0.017345523,-0.03643255,0.025640449,0.037900344,-0.06287055,-0.0070087956,0.055429615,-0.053444814,-0.020641174,0.036840126,0.06720276,0.04359768,0.04730978,-0.021831296,-0.02979795,0.002100331,-0.008542554,-0.05409075,0.0072727823,0.049156852,0.0059284647,-0.048035327,-0.031162204,-0.08168819,0.06434314,-0.030963372,0.05219542,0.02458415,-0.053104915,0.018919004,-0.056728773,0.034919698,0.08443753,-0.010644954,0.011295837,0.05247837,-0.021965414,0.03537592,-0.07968715,-0.14121349,0.034361087,0.029349372,-0.048653122,0.0016840952,-0.03351175,0.04719274,0.05135164,-0.09338225,-0.045915827,0.062067218,0.025153823,-0.022458134,-0.10058733,0.0882619,0.055902783,-0.07565616,0.01312526,-0.0057868967,-0.00937984,-0.04528101,0.016360056,-0.092781074,-0.022013336,0.035123397,-0.017512115,-0.05027798,-0.05763666,0.051734403,-0.04180996,-0.019585514,-0.08739772,0.0333883,-0.07862756,-0.006227204,-0.05856237,0.044880327,-0.07527784,-0.03933914,0.06518608,0.074073285,-4.745622e-33,0.043159626,-0.12072471,0.016897254,-0.0029488755,-0.03287556,0.07340092,0.0020706863,0.000907836,0.0049635433,-0.02260853,0.0008278486,-0.07809528,0.043279704,-0.00055672583,0.039295215,-0.0074514365,-0.008306216,0.03368018,-0.03406286,-0.0066741602,0.0077983993,0.077321775,0.0854604,0.0038831134,0.0020522561,0.052851334,-0.029186979,0.07622351,0.054985832,0.030729337,-0.042240433,-0.008226579,0.0015418996,-0.0024916122,-0.017183589,0.039914116,-0.046815444,0.023980102,-0.021092203,-0.055816256,0.05427282,0.049501784,0.045861892,0.038755048,-0.033035103,0.02381464,-0.089011274,0.02476157,0.0024496778,-0.02537769,0.03854754,0.027670242,-0.062055238,0.03821624,0.010040869,0.083769016,-0.010232044,-0.036335308,-0.017484495,-0.0034943281,-0.09605425,-0.102240145,0.055759765,0.0657679,0.007297191,0.065953314,-0.024827372,0.106843084,0.008114834,-0.057166584,0.10880153,0.10638188,-0.012724515,0.037253704,-0.055619348,-0.073135905,-0.050846662,-0.004163713,0.012239514,0.012131674,0.03173106,-0.054134846,-0.09311227,-0.007902766,-0.045610193,-0.10452799,0.015596138,0.10059502,0.018924933,-0.013870685,0.03724165,0.03182801,-0.111808784,0.03840774,0.037996102,-3.6045265e-08,-0.024669781,0.0033881508,0.05269651,0.034538724,0.010562803,-0.053986225,0.04818513,0.059880797,0.043161247,0.014624336,0.012765485,0.07177189,-0.052404657,-0.053650007,0.054950308,0.024088964,-0.077851765,-0.0051877936,-0.028356291,-0.016572384,-0.039763853,-0.019971194,-0.07709818,0.041599013,0.0021644707,-0.048816368,0.047285248,0.045747954,-0.06583192,-0.016131293,-0.044688307,0.083128296,-0.04522099,-0.007505444,-0.05690085,0.052876573,0.004356601,-0.0155093605,-0.043852687,0.02855329,-0.005514681,0.020082809,-0.14667246,-0.012249173,0.052855033,0.0014661197,0.029576674,-0.012689944,-0.02598897,0.04739878,0.09817761,0.051199824,0.045494255,0.0021071213,-0.12571387,0.008284954,-0.012142341,-0.06265975,-0.06346808,-0.00815775,0.068621024,-0.022959147,0.24467196,0.04521765 +1.1.2.7,"A periplasmic quinoprotein alcohol dehydrogenase that only occurs in methylotrophic bacteria. It uses the novel specific cytochrome cL as acceptor. Acts on a wide range of primary alcohols, including ethanol, duodecanol, chloroethanol, cinnamyl alcohol, and also formaldehyde. Activity is stimulated by ammonia or methylamine. It is usually assayed with phenazine methosulfate. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ. It differs from EC 1.1.2.8, alcohol dehydrogenase (cytochrome c), in having a high affinity for methanol and in having a second essential small subunit (no known function). ",384,1.0,-0.07288595,-0.033587825,-0.04487284,-0.10288578,0.038349997,0.017854348,-0.031037945,0.06961106,0.07732102,0.034239817,0.011986457,-0.047374334,-0.06333091,0.06978816,-0.053586923,0.070754915,-0.026345178,-0.07435095,0.0645719,-0.023653163,0.023067595,-0.0047427285,-0.034292344,-0.031767618,-0.0135510685,0.058827672,0.022084165,0.119385414,-0.02926631,-0.039809257,0.009500835,0.030390784,0.07231693,-0.009616293,0.04791864,0.08780051,-0.06305535,-0.04630826,0.019300256,-0.014729586,0.050696503,0.07061862,-0.027982278,0.017957428,0.019069973,-0.0074927104,-0.035619225,0.09519449,-0.04161264,-0.026512582,-0.0047700787,-0.05905385,0.06707593,0.060009267,0.08328763,0.035096303,-0.07197268,0.0021990226,-0.030409977,0.0489281,-0.0125712305,0.037766203,-0.006175795,0.0039593223,0.043265723,-0.059455764,0.043422032,-0.022866754,0.0676283,-0.06553907,-0.06159168,-0.06482406,0.028724294,-0.030139333,-0.051214222,0.027358074,-0.018286817,-0.025904413,-0.03475839,-0.07743899,-0.012841652,0.016378477,0.015968215,0.084031455,0.10356693,-0.020247202,-0.018479472,-0.037966773,-0.025756171,0.015166931,-0.015843853,-0.022959527,-0.05359981,-0.10583893,-0.008520935,0.12547985,0.033442337,-0.011306827,0.030621408,-0.02536334,0.060529977,0.104564,-0.039934125,-0.07176446,-0.066013806,0.013168639,0.024292642,0.1019156,-0.018535879,0.0044658277,-0.0122213885,0.018180039,0.0699995,-0.021558154,0.048132073,0.04029551,0.07419962,-0.024957262,0.02340621,-0.046294674,-0.047835786,-0.04545556,0.02882462,0.015427122,0.037990615,0.026108745,-0.10574554,2.881522e-33,0.038444508,0.016393397,-0.032339588,0.025257282,-0.0063811084,-0.031198505,-0.022571145,0.08014827,-0.049817644,-0.024721654,0.003059212,-0.026514795,0.05066633,-0.013949716,-0.032854814,0.020408198,-0.03148788,-0.021023449,0.039798617,-0.006870308,0.020673873,0.0027619444,-0.082974516,-0.008098305,0.044039264,0.080541454,0.0002552899,0.003744788,0.031587653,0.00036435708,-0.024049371,-0.023921268,-0.055967398,0.0053215954,0.0013560489,0.032544047,-0.07446143,0.033896282,-0.08403019,0.032108266,5.2027048e-05,0.0028239237,0.038027346,-0.060515914,0.029484082,-0.06818132,-0.061329823,0.061899368,0.017882625,-0.007017139,0.06931793,-0.022048455,0.08817581,-0.092566304,-0.10908105,0.053080108,0.030028913,-0.022768969,0.011311557,0.056934442,0.015763165,0.048074797,-0.13805138,0.007969609,0.054610305,0.020673994,-0.10543107,-0.1277445,0.033025607,0.13592711,-0.054775897,0.012218883,0.079926655,-0.019121354,-0.013757335,0.010270569,-0.07540125,0.039031483,0.06437649,0.06322816,0.027030744,-0.045183007,0.06613954,-0.02751941,-0.032805495,-0.09872796,0.05260477,-0.07837705,-0.022993047,-9.806167e-05,0.03765199,-0.10613101,-0.024727488,0.038579267,0.003096337,-4.2334896e-33,0.08094075,-0.060283452,0.055450074,-0.05218531,0.001114573,0.10799696,-0.02439528,-0.028612617,0.0047975783,-0.08889332,0.07482652,-0.0067427903,-0.017154412,0.0039215013,0.026250731,0.059648246,-0.05719085,0.08653787,-0.020884098,0.04555095,-0.012157718,0.08767725,0.07559419,0.033453874,0.058085144,-0.0142491115,0.04104486,-0.0023401845,0.026362324,0.056562815,-0.06591614,-0.00946874,-0.019602342,-0.056269564,-0.038034003,0.038790587,-0.13031462,-0.035929658,-0.008590002,0.02743392,0.015315541,0.011148756,-0.011966487,0.013665002,-0.0007705855,0.08650147,-0.10812024,-0.012423018,-0.022923656,0.00077441696,0.06659015,0.007901506,-0.03451624,0.08475506,0.042781696,0.08690903,-0.030274818,0.009171592,0.020553792,-0.014130316,-0.07743078,-0.04270445,-0.03768351,0.023920465,-0.027727026,0.009992803,-0.058337893,0.1113641,-0.005476087,-0.039375823,-0.005198598,0.024838958,0.0038367335,0.016482882,-0.09065391,-0.04216899,-0.06714998,-0.046955395,0.013505706,0.048822712,0.037197106,-0.0032775335,-0.052427333,-0.014629001,-0.00431099,-0.049772415,0.0382681,0.069417365,-0.038636483,-0.0072322367,0.04206836,0.0374336,-0.07570865,0.044051666,0.04251747,-4.7353172e-08,-0.010186015,-0.0358073,0.045779362,0.008134445,0.021162173,-0.015683236,0.04190865,0.0062448056,0.01409186,0.039530236,0.024045205,0.05861791,-0.036476564,0.0016369023,0.013784024,0.06048252,-0.04940281,-0.0514865,-0.019616617,-0.011457668,-0.07105979,0.0042695575,-0.0852314,0.012199933,-0.006129952,-0.048495803,-0.0034820251,-0.033718064,0.0005622768,0.0022807918,-0.034001634,0.04825582,-0.013355541,-0.016759546,-0.062257655,0.0142157525,-0.025916524,-0.043486875,-0.087194934,0.030226821,0.06582549,-0.078393385,-0.110487685,0.022569904,0.024117528,-0.00023713238,-0.024846798,0.018750018,-0.046133474,0.01997622,0.081401974,0.015706005,0.060471166,-0.069375746,-0.10773736,0.025339304,0.004698634,-0.09243113,-0.019098446,-0.06331863,0.11614585,0.006014719,0.18882905,0.035164636 +1.1.2.8,"A periplasmic PQQ-containing quinoprotein. Occurs in Pseudomonas and Rhodopseudomonas. The enzyme from Pseudomonas aeruginosa uses a specific inducible cytochrome c550 as electron acceptor. Acts on a wide range of primary and secondary alcohols, but not methanol. It has a homodimeric structure [contrasting with the heterotetrameric structure of EC 1.1.2.7, methanol dehydrogenase (cytochrome c)]. It is routinely assayed with phenazine methosulfate as electron acceptor. Activity is stimulated by ammonia or amines. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ.",384,1.0,-0.095241144,-0.0147132715,-0.07441971,-0.069362506,-0.0009428962,0.038365055,-0.04404883,0.06906806,0.06304825,0.056240186,0.006166917,-0.019727524,-0.046629943,0.092216134,-0.06084933,0.09254382,-0.050044473,-0.0640221,0.06730652,0.017400848,0.014658891,0.023105446,-0.04927373,-0.04737337,0.00693168,0.07028802,0.03961642,0.10789093,-0.020410644,-0.023487208,-0.023899503,-0.0012373092,0.09214204,-0.020103097,0.06599795,0.10344672,-0.07059963,-0.029988708,0.044635944,-0.017833527,0.064360335,0.026340213,-0.016570244,-0.014887309,0.065821424,-0.028347712,-0.026067834,0.1077124,-0.0015130262,-0.072712414,-0.025259625,-0.064997114,0.04944663,0.08548457,0.04426021,0.061849188,-0.06472518,-0.029280322,-0.027501378,0.023480644,-0.025408735,0.018391062,-0.004290758,0.015366391,0.036569253,-0.05060312,0.052919187,-0.023254838,0.090720035,-0.06722718,-0.055151403,-0.04335015,0.06229026,-0.048765607,-0.03939966,0.0020385033,-0.010992765,-0.027717307,-0.008276951,-0.07499566,-0.0008072919,-0.040548567,-0.0064500826,0.08137982,0.10163873,-0.027841195,-0.038247775,-0.017468806,-0.0009313832,-0.034008723,-0.01392923,-0.045278575,-0.078206345,-0.08998178,-0.033546057,0.08592102,0.034236647,0.0050062975,0.034477636,-0.027483055,0.07449039,0.0709662,-0.032303765,-0.06921511,-0.043078743,0.01239631,0.04115049,0.09824765,0.0074716364,-0.0092163,-0.020452859,-0.018380905,0.055230882,-0.029679134,0.025827043,0.03703224,0.076009594,-0.036915656,-0.005789858,-0.053505413,-0.045905847,-0.036744457,0.028457373,-0.0241071,0.044424064,0.01946479,-0.09791102,3.693783e-33,0.061546333,0.022079134,-0.007208958,0.0055695837,0.019713191,0.0044350815,-0.025179263,0.04730161,-0.034693185,-0.045374263,-0.017342584,-0.015007427,0.049522243,-0.0062859603,-0.059100527,0.043458138,-0.043531187,-0.028572012,0.044879247,0.0058209137,0.04319797,-0.025127186,-0.10360356,0.0016927796,0.044827107,0.078086056,0.0028146536,0.012837373,-0.0070082285,0.0032940432,-0.014540131,0.014336006,-0.073387876,-0.008618647,0.019408666,0.022980036,-0.09607548,0.025958328,-0.06585022,0.026372185,-0.0053674853,-0.0011521366,0.009174215,-0.04940441,0.021934869,-0.022084618,-0.0692724,0.062449757,0.010843545,0.008998288,0.08545622,-0.06455061,0.06367469,-0.057394996,-0.08729963,0.009467355,0.018111987,-0.016055843,0.04545416,0.05727483,0.028639287,0.036267396,-0.13672209,0.0297897,0.014389271,0.015134315,-0.07547751,-0.07928177,0.031002803,0.14673172,-0.047430236,-0.00363862,0.04662919,0.031467315,-0.021007244,-0.024309497,-0.044347554,0.05917714,0.06552622,0.051998526,0.05857861,-0.07053779,0.04764948,-0.003009336,-0.053485494,-0.07568172,0.0705015,-0.09068018,-0.0319284,-0.0038205767,0.056496166,-0.117239654,-0.03272362,0.059828322,0.0058535268,-4.993576e-33,0.093381085,-0.048372764,0.03293794,-0.054124545,-0.019099478,0.076523155,-0.0100956615,-0.005751095,0.0634746,-0.085204974,0.0801871,-0.006257186,0.015376028,0.036468316,0.034095168,0.059401985,-0.031160204,0.04172437,-0.026904615,0.031199964,-0.0057453313,0.044690225,0.016768945,0.0201215,0.07158331,0.008676569,0.026424076,-0.010716967,0.020614548,0.06619925,-0.07390886,-0.020278046,-0.052094743,-0.07580934,-0.031281564,0.042626474,-0.08931027,-0.010565747,0.019417435,-0.004146387,0.050778218,0.017477764,-0.025258057,0.064661264,-0.005876383,0.08340935,-0.09312166,-0.02476881,-0.034778323,-0.06466139,0.046157036,0.0077088024,-0.007672644,0.08786725,0.031003473,0.07316014,-0.036261864,0.008235193,0.025726387,-0.033016235,-0.09032263,-0.09599716,-0.044847142,-0.024184234,-0.009253191,0.015644012,-0.0025180944,0.09506229,0.024483144,-0.07405932,-0.01631715,0.019995054,0.023658061,0.010428907,-0.118101954,-0.0029179025,-0.08036352,-0.060724787,0.025168166,0.038096458,0.06065638,-0.04119601,-0.033472978,-0.020994883,-0.022924924,-0.056322053,0.06373422,0.08445094,-0.049590744,-0.009019763,0.04503166,0.04463736,-0.03493376,0.053799793,0.03190657,-4.680844e-08,-0.006453788,-0.022582594,0.0361333,-0.001889572,0.050124023,0.009541763,0.025558233,0.00092158833,0.03752173,0.03243387,0.009927319,0.052742444,-0.025685474,-0.0031437103,0.017268006,0.062568404,-0.08121932,-0.048719283,-0.029902328,0.0077063194,-0.084755555,-0.0281888,-0.102924965,0.0051556346,0.0018639977,-0.030882683,0.035088714,-0.041046195,-0.024208937,-0.022472098,-0.060914196,0.023523882,0.012810634,0.026893519,-0.08053799,0.018015195,0.0058887196,-0.07110099,-0.074397996,-0.0307389,0.086959586,-0.09763657,-0.09159078,0.028152553,0.0046327184,-0.0045906417,-0.031660434,0.013407383,-0.047425598,0.0130273355,0.09277224,-0.015486641,0.07681244,-0.06856631,-0.11658379,0.017312083,0.0039586234,-0.053918786,-0.028215904,-0.06138388,0.10348309,-0.008133446,0.17118566,0.057624858 +1.1.98.1,"A soluble, periplasmic PQQ-containing quinohemoprotein. Also contains a single heme c. Occurs in Comamonas and Pseudomonas. Does not require an amine activator. Oxidizes a wide range of primary and secondary alcohols, and also aldehydes and large substrates such as sterols; methanol is not a substrate. Usually assayed with phenazine methosulphate or ferricyanide. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed β€˜propeller’ structure, a calcium ion bound to the PQQ in the active site and an unusual disulphide ring structure in close proximity to the PQQ.",384,0.99999994,-0.05251936,-0.017845698,-0.039552737,-0.053928442,0.007816026,0.009424094,-0.010398308,0.085720204,0.048500463,0.038824756,0.053482357,-0.04130616,-0.07241488,0.0965497,-0.056859273,0.06302927,-0.060039558,-0.04169633,0.038980603,0.017211393,0.016017165,0.068272114,-0.04341256,-0.006637234,0.00691723,0.042460743,0.04452526,0.09303121,0.0070157005,-0.026725,-0.015017041,0.052971423,0.09740683,-0.00017103701,0.078790635,0.09371956,-0.052240096,-0.027170142,0.033745795,-0.025521029,0.09360001,0.032542363,0.007316777,0.0087877195,0.07038778,-0.002634498,-0.035715997,0.10205125,-0.03265307,-0.00942522,-0.0589667,-0.07660711,0.035637777,0.096933305,0.06258615,0.056497492,-0.02895766,0.011189272,-0.027741471,0.057157956,0.012473495,0.054831896,-0.00134025,-0.027271548,0.021564519,-0.05860313,0.0770568,-0.009885278,0.0670937,-0.050193388,-0.033365577,-0.03183575,-0.00881152,-0.026066236,-0.044244584,0.026066037,-0.021427387,-0.05757459,-0.016868414,-0.052088052,0.017130753,-0.0014406745,0.033580046,0.08265474,0.11085713,0.010908785,-0.05564166,-0.03694111,-0.025438758,-0.0594186,-0.017565744,-0.011980571,-0.027144963,-0.101219326,-0.01119454,0.09106491,0.034167804,-0.03449446,0.010971822,-0.006470736,0.04260798,0.025850696,-0.0344073,-0.039803907,-0.079458944,0.035219397,0.017673206,0.058428522,-0.0055316095,-0.0071390523,-0.0017989605,0.0048935274,0.09267406,-0.043744106,0.051543552,0.028151192,0.045288734,-0.0068907035,-0.0068585277,-0.06316418,-0.024054118,-0.033879686,0.044165496,-0.017047383,0.015610405,0.0013338341,-0.07369925,4.1515055e-33,0.09604102,0.025853714,0.0036733893,0.030244296,-0.006396712,-0.026680488,-0.0091197835,0.041246206,-0.053211514,-0.042003848,-0.007811114,-0.043178096,0.03028451,-0.010252226,-0.018784478,0.002540723,-0.053379208,-0.0092685595,0.05861621,-0.010336004,0.009589364,-0.005395839,-0.13311659,0.00354439,0.052962296,0.05009514,-0.0062855515,-0.010596495,0.022971798,-0.005896323,-0.014671539,0.0074085025,-0.10149097,-0.006043294,-0.009426855,0.032972954,-0.10683477,0.0143203875,-0.13483171,0.03594452,-0.0074413586,0.034383345,0.012927639,-0.05998116,0.02609187,-0.04749004,-0.05808073,0.056789305,0.031529654,0.018342834,0.0356369,-0.024601776,0.072050326,-0.047261506,-0.08456979,-0.0015839764,0.017377697,-0.02564006,0.06418103,0.03380248,0.04382502,0.018903978,-0.15551737,0.023396501,0.0011850753,0.02335916,-0.105657786,-0.097589426,0.048625354,0.13160479,-0.0062507065,0.0024601393,0.044274844,-0.009757158,-0.034187585,-0.033541985,-0.06042206,0.058146175,0.036586225,0.020560866,0.06363366,-0.06704941,0.049467817,-0.0004367052,-0.025237095,-0.073742025,0.079748765,-0.050145544,-0.040817425,-0.02952266,0.029145297,-0.08429648,-0.034986317,0.009341881,0.029919598,-3.879893e-33,0.092839986,-0.051473826,0.0027285295,-0.017100526,-0.020518677,0.06235048,-0.010595359,-0.018186754,0.008521436,-0.1353181,0.051480033,-0.008085762,-0.011584612,-0.010856394,0.039593156,0.06664461,-0.034343384,0.05231434,0.01747452,0.023996808,0.0069971518,0.042709824,0.048659716,0.013501479,0.08707241,0.008605632,0.015457551,-0.023511665,0.0077440534,0.08260208,-0.086765,-0.04415322,-0.06024548,-0.06582123,-0.070539355,0.023738956,-0.10336885,0.009727024,0.003894936,0.020651752,-0.008400452,0.0021029417,0.0314492,0.08899051,0.0026348399,0.07625821,-0.06766301,-0.023399858,-0.011005068,-0.01866116,0.054365482,0.020350805,-0.05060607,0.056128126,0.033168137,0.077417724,-0.02224404,0.032478277,0.013291119,-0.041927245,-0.077578,-0.051244676,-0.05213832,-0.043499365,0.015948003,0.067149505,-0.009794701,0.1344679,0.020309068,-0.101637796,0.019778095,0.016294241,0.052574903,0.0080648605,-0.09570145,-0.02956854,-0.08115415,-0.0037998357,0.025507096,0.06048587,0.054404587,-0.037144337,-0.03367575,-0.008386861,-0.028223593,-0.087351106,0.049663413,0.06826076,-0.027803043,0.024888113,0.010013188,0.039678946,0.0018146494,0.043317325,0.05415262,-4.510637e-08,0.013957609,-0.04966374,-0.01275307,-0.026907163,0.020484494,0.012387001,0.04421085,0.024276651,0.04918865,0.047331166,0.031302676,0.037417583,-0.05577545,0.02312081,0.041931935,0.03612953,-0.0958033,-0.020848125,-0.07512685,-0.014578616,-0.07895373,0.027245946,-0.09067264,0.005884446,-0.050452266,-0.004958143,0.014899833,-0.058666993,0.0032505793,0.008672912,-0.05127088,0.061155982,0.019630909,-0.03452481,-0.075676054,0.02308407,-0.02197289,-0.029197589,-0.06485973,-0.0129930945,0.020739269,-0.111192055,-0.09685226,0.021244187,0.054487783,-0.0145624755,-0.02132796,0.01662469,-0.041637763,-0.004799583,0.07310575,-0.005892176,0.056825515,-0.029368108,-0.14805466,0.02976689,0.036196366,-0.047799908,-0.045349784,-0.08922742,0.07389863,-0.0005198444,0.21373354,0.07232501 +1.1.99.35,"Soluble periplasmic enzyme containing a tightly-bound PQQ cofactor that is bound to a calcium ion. As the electron acceptor is not known, the enzyme has been assayed with Wurster's Blue or phenazine methosulfate. It has negligible sequence or structure similarity to other quinoproteins. It catalyses an exceptionally high rate of oxidation of a wide range of aldose sugars, including D-glucose, galactose, arabinose and xylose, and also the disaccharides lactose, cellobiose and maltose. It has been described only in Acinetobacter calcoaceticus.",384,1.0,-0.13814618,-0.05902765,-0.06625948,0.018515315,-0.07501603,0.038838055,-0.022540629,0.06644505,0.06915548,0.058481026,-0.008470189,-0.0138831325,0.0055593182,0.03206758,-0.111115895,0.054719497,-0.051269997,-0.043621577,0.024626985,-0.030228248,0.07043707,0.008479272,-0.025551742,-0.07239204,0.06553609,0.04167998,-0.001723613,0.0068203458,-0.021258833,-0.059120495,-0.03159685,-0.0822079,0.060937785,0.014646605,0.080521286,0.12813306,-0.02921389,-0.10537254,0.039799992,-0.033657108,0.036210075,0.061669108,-0.022175804,0.04425454,-0.005549893,-0.014709291,0.030124335,0.058628608,-0.0065668537,-0.02542064,-0.050409313,-0.035499956,-0.021424836,0.032132536,0.024922578,0.028664622,-0.036055665,-0.058036603,0.04137155,0.014664142,0.02899139,0.035723843,0.007519757,0.00509962,-0.005550522,-0.05943184,0.054508682,-0.063786566,0.0014300764,-0.06097538,-0.06820471,-0.05534574,-0.026765062,-0.011849176,0.009123702,0.008707675,-0.010074102,-0.069631524,-0.03169934,-0.0035781555,-0.018855713,-0.053352755,-0.015300513,0.086934805,0.033856343,-0.067190625,0.031361133,0.012652956,0.030126018,-0.04437908,-0.024425998,0.013550316,0.01778946,-0.048349455,-0.046507847,0.04160883,0.057751365,-0.012585301,0.01006455,-0.06717056,0.033237647,0.07877954,0.013393081,-0.042598993,-0.006702668,-0.0014048958,0.01451306,0.12594773,0.030002289,0.016772015,-0.005796162,0.0766708,0.021308087,-0.033832375,0.02208629,0.06876396,0.069768086,-0.059484627,-0.0012253745,-0.035564136,-0.052279998,-0.059995845,0.003161517,0.0027571325,0.044144336,0.018205177,-0.06720588,4.401213e-33,0.054154493,0.044339113,0.013867,-0.040634383,0.038278542,0.008225938,-0.04252073,0.0923092,0.013077974,-0.009927401,-0.04869676,-0.046103686,0.025759777,0.026454164,-0.043440398,0.024037125,-0.058766343,-0.078004286,0.06889039,0.032044638,-0.016187899,-0.017628824,-0.030437794,0.04290577,0.056390338,0.048184864,0.012656704,0.046938475,-0.0067157927,-0.02611243,0.049832795,-0.046748657,-0.09545316,-0.066532925,0.0105270175,0.006145755,-0.07020035,0.07452742,-0.0670251,0.07720313,-0.010824258,0.017758375,0.040583592,-0.040017556,0.06860992,-0.018026583,-0.07487318,0.08918926,0.030600214,0.052640654,0.05560991,0.0025466385,0.05288766,0.011331832,-0.06964909,0.054554,0.007128096,0.01219486,0.03218168,0.06872964,0.09775228,0.0657125,-0.049768098,0.036452863,-0.031233793,0.011114646,-0.05515102,0.011886215,0.018646777,0.10866298,-0.09993841,-0.0009952992,0.024159271,0.0058179395,0.018244455,-0.04556702,-0.03454332,0.011568027,0.037854843,-0.041038733,0.04371891,-0.0629573,0.092739746,0.012566995,-0.097126536,-0.06896052,0.007244423,-0.015398721,-0.031959932,0.012116044,0.040654067,-0.029563665,-0.06913296,0.016128821,-0.037762146,-5.336145e-33,0.12413472,-0.11044663,0.07332389,-0.049586333,0.0006530451,-0.022226285,0.002889741,0.06014273,0.057847843,-0.097170256,0.085623905,0.04743049,0.03890445,-0.040469095,0.027077485,0.09671171,-0.04500463,0.07462641,-0.028278716,0.049848117,-0.04397995,0.099838845,0.021086482,-0.0357125,0.032135773,-0.018379418,0.0408629,0.00095635,-0.0037358413,0.033099134,0.008979616,-0.027648875,0.0024808415,-0.13971417,-0.110014215,-0.023583103,-0.09208307,-0.015137464,0.028920256,0.04809876,0.08297351,-0.01042126,-0.054654393,0.08401871,0.03508294,0.042078838,-0.079468876,-0.058521368,-0.010558444,0.020316647,0.04715356,-0.01133862,0.022292063,0.047098704,0.065375336,0.06250156,-0.0242464,-0.011046276,0.035443462,-0.012474277,-0.0781073,-0.02658736,0.07781398,-0.057822086,0.07763132,0.037879776,-0.04795737,0.06823111,0.031357862,-0.027988922,0.056157842,-0.022449253,-0.067643076,-0.039794445,-0.06280949,0.042374406,-0.08037614,0.0019602117,-0.03174652,0.006986866,0.0031519458,0.012093621,-0.017651768,-0.055585448,-0.054641914,-0.030658446,0.048398018,0.046163,-0.037368935,0.017664395,-0.043116286,-0.0049821213,0.02888593,0.019380884,0.06171124,-4.5341427e-08,-0.014488985,-0.001984866,-0.01254639,0.0019550377,0.0236864,0.061274637,-0.0025304363,-0.017819919,0.03413293,0.037217967,0.0034559024,0.11543301,-0.056333344,0.04966424,-0.02102605,0.047150597,-0.09520736,-0.03821251,-0.017286954,0.067146465,-0.14817818,0.029956019,-0.06969142,0.014784979,-0.009892555,-0.010443762,0.017835738,-0.0666665,-0.017399546,0.017076107,-0.037168443,0.078406245,0.02710751,-0.08802866,-0.05687934,-0.015240157,0.0011509516,-0.086205974,-0.027024262,-0.023365937,0.059431244,-0.042089228,-0.06650586,0.01947424,-0.00753117,-0.010418022,-0.027199756,0.012623993,-0.02049441,0.036333915,0.081144854,-0.0031559898,-0.07499156,-0.08968268,-0.08938195,0.031584185,-0.002942455,-0.04180433,-0.05441516,-0.04521664,0.07381898,-0.068715654,0.1942601,-0.00036168404 +1.2.5.1,"Flavoprotein (FAD) [1]. This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone [2,3]. Does not accept menaquinone. Activity is greatly enhanced by lipids [4,5,6]. Requires thiamine diphosphate [7]. The enzyme can also form acetoin [8].",384,0.99999994,-0.10434117,-0.054324344,-0.15656644,0.00042280517,0.028090915,0.019913163,-0.021443166,0.034398347,0.015909988,-0.03909137,-0.0067418357,0.0346932,-0.0670763,0.04172114,-0.05238143,-0.006329804,-0.03264166,-0.03320151,0.026347796,-0.028332835,0.044736598,0.03625974,0.0028238888,-0.10327279,-0.0064152875,-0.04142997,0.013562113,-0.010899921,-0.04292535,-0.028528225,0.06875392,0.016983991,0.07889755,-0.034007102,-0.025117,0.04345456,0.017141035,-0.006319733,0.028889094,-0.00743375,0.024687357,-0.001025094,0.06047875,0.013442443,0.091796145,0.0058890055,-0.023253925,0.06765569,0.07420499,0.03558647,-0.051380984,-0.041463878,-0.04864793,0.08515863,-0.02677404,0.03461023,-0.015457463,-0.08809694,0.0022878787,-0.00034401854,0.018380953,-0.027020141,0.11274332,0.015595396,0.00056894106,-0.09111718,-0.049561363,-0.046917316,0.029235372,-0.0070873722,0.03322955,-0.042248283,-0.08261195,0.031970378,-0.0053086374,0.07166641,-0.06707581,-0.049363546,0.056157973,-0.00935066,0.09311845,-0.035815064,0.05374124,0.1634302,0.029847823,-0.032079156,-0.020986756,-0.045709934,-0.046849545,0.076229356,0.022650527,0.008946648,-0.031171998,-0.017584572,-0.10338195,-0.0017324171,0.05052195,0.007395661,-0.094287254,-0.02941356,-0.012625057,-0.032694634,0.0035202105,-0.062023703,-0.057719447,-0.016014686,0.012371804,0.03226166,-0.0033316857,-0.052991763,-0.040889174,-0.0051934305,-0.012698402,-0.11084701,0.023526866,0.011898458,0.027655696,-0.041601095,-0.059243977,0.02361353,-0.08716989,0.06947976,0.07330457,0.05167462,0.059265647,0.009877232,-0.12195946,2.5012799e-33,0.051409397,-0.00020420415,-0.012182264,-0.047032516,-0.008191409,-0.029441468,-0.014716337,-0.022941755,0.019354586,-0.06086688,-0.04779695,-0.03298245,-0.0009805099,-0.01624635,0.024462827,-0.0027762156,-0.017402716,-0.055164758,0.067135535,-0.0946222,0.018205795,0.01929998,-0.014840435,-0.01556682,0.06598897,-0.00096675137,-0.041451477,0.03039391,0.035748348,0.038613833,-0.0390634,-0.045099236,-0.08674972,-0.0142922085,0.04019774,0.049415667,-0.07699916,-0.044058286,-0.122765005,0.060148533,0.061251644,-0.008296409,-0.031512875,0.018267246,0.050165236,-0.024331147,-0.10196855,0.16233772,0.05455993,0.038823277,0.033069246,-0.035661235,0.14087196,0.03215986,-0.061863273,0.040224195,-0.0051330826,0.012137962,0.03031952,-0.0069156224,0.019423552,0.022162395,-0.045591764,0.083756454,-0.061318535,0.016175104,0.010503953,-0.078305684,0.001116477,0.09229726,0.036766496,-0.030615725,0.08891905,0.048059817,0.039582625,-0.02394258,-0.029832598,0.0046498803,0.03508049,-0.03919446,0.026874015,-0.04950413,-0.017294593,-0.0145736,-0.000595207,0.0122826975,-0.0024052425,-0.049754538,-0.0028032847,0.008401434,0.04141804,-0.05168634,-0.004912955,0.050580136,0.019563336,-2.919266e-33,0.035594553,-0.12305075,0.08769483,-0.026698133,-0.016849766,0.098040365,0.013404941,-0.012353593,0.018557131,-0.010976742,0.00965471,-0.06989235,-0.005190322,3.620461e-05,0.041812163,0.026760435,-0.055376317,0.01618869,0.03293524,-0.010833989,-0.06266434,-0.02722049,0.07716368,0.081446715,0.014553807,-0.0010629419,-0.011619849,-0.01938406,0.02524896,0.03496376,-0.05006245,0.041804958,-0.11141528,-0.031117126,-0.063887306,0.031449858,-0.038601525,0.0069875983,0.031225104,0.009648587,0.02844383,0.011516023,-0.017179955,0.047783438,0.08326929,0.095085405,-0.029794171,0.042599145,-0.011573838,-0.06200935,0.013733244,0.0005659397,-0.04160184,0.08619838,0.09011765,0.10845429,0.082444996,0.03549195,0.041040547,-0.030068854,-0.021869943,-0.10912842,-0.012530772,-0.0008607454,0.06312705,0.12616773,0.07623179,0.11493214,-0.03609469,-0.006612693,0.086787514,-0.04142575,0.043127604,0.07756831,0.02280895,0.039796647,0.018516174,0.039129328,0.012284323,-0.0039435835,0.016834492,-0.012731776,-0.038772743,0.009360776,-0.02897222,-0.10866077,0.05303701,0.037270088,-0.022590974,0.06147657,-0.042714126,0.06406671,-0.074295595,-0.07113564,0.055670366,-4.1590514e-08,0.06905474,-0.03828146,0.074704885,-0.044990838,0.06016092,0.0036597433,-0.037225943,-0.0059356503,0.050741855,-0.02007191,-0.064706035,0.10122542,0.015876086,-0.013407012,0.033220194,0.0014788335,0.0009529225,0.026320836,0.00033964514,-0.041234635,-0.071775496,0.04473356,-0.084760465,0.0026592147,-0.034940667,-0.035242412,-0.0007421115,-0.0037767023,0.019510783,-0.037598833,-0.019086698,0.050491843,-0.010685728,-0.06583097,-0.113487646,0.008444299,0.004909987,-0.08219338,-0.023625549,0.020431992,-0.07280061,-0.02814825,-0.008718976,-0.051474072,0.009445774,-0.004605718,0.05409834,0.068283685,-0.08556968,-0.024584202,-0.032982063,-0.028914265,0.03630768,-0.0428227,-0.09734918,0.024089493,-0.020372804,-0.07726955,-0.022207722,-0.06555635,-0.040338535,0.0336033,0.112778954,0.045742333 +1.3.5.3,"Contains FMN. The enzyme participates in heme b biosynthesis. In the bacterium Escherichia coli it interacts with either ubiquinone or menaquinone, depending on whether the organism grows aerobically or anaerobically.",384,0.99999994,-0.026896484,-0.015353419,-0.11649887,0.01835492,0.0054499214,0.066190824,0.0010249778,0.05634933,0.019128324,-0.05882548,-0.021980096,-0.071082026,-0.066163346,0.0827156,-0.030869178,0.03527534,-0.06305821,-0.008448595,-0.05232116,-0.0468341,0.03287069,0.08536515,-0.008589304,-0.0024014332,-0.08217185,-0.04341033,0.07384382,-0.00019615787,-0.007048162,-0.06624992,0.048543274,-0.0155684035,0.11924061,-0.029485889,0.05938074,0.053577136,0.06639272,-0.1115607,0.052282996,-0.013992907,-0.0014562925,-0.03938325,-0.0066155004,0.017431255,0.053164102,0.030773079,0.040589046,0.011189928,0.021077914,0.03388012,-0.04576025,-0.0010015481,-0.035736684,0.10454442,0.07501565,0.03556602,-0.007448653,-0.012293658,-0.015866484,0.018865297,-0.019716695,0.06439282,0.037695393,0.0014060974,0.04931651,-0.02590504,-0.014224791,-0.032575756,-0.03932421,-0.058416396,0.033428695,-0.09304769,-0.08891944,-0.019452933,-0.05577153,0.061641946,-0.011345675,0.018501997,-0.00681624,-0.028723387,0.028559584,-0.026868233,0.0529279,0.15132852,0.0017932513,-0.018408913,-0.0077154436,-0.019116184,-0.021319797,0.10485751,-0.0061536045,-0.039047383,-0.013653821,-0.14098068,-0.013322814,0.0075530107,0.011360867,0.058384422,0.030085089,0.0119084455,-0.047423083,0.030915687,-0.056826994,-0.0030643994,-0.0734104,0.0011836373,0.06005042,0.059406545,0.124509156,-0.021699952,0.0022983348,0.03931007,0.025861613,-0.017692775,-0.042769175,-0.00603242,0.0662201,-0.0732396,-0.036190234,0.031118935,-0.03365091,-0.0015515378,0.018211775,0.08001359,-0.0021150324,-0.013893467,-0.1693018,2.8139954e-33,0.0291402,-0.008765605,0.03602346,-0.03263248,-0.03617048,-0.033417996,-0.031857196,-0.03190371,-0.0010151106,-0.056216244,-0.0817338,-0.024084255,0.05612863,0.008973266,-0.010885224,-0.025142329,-0.031338308,-0.057595603,0.01862034,0.028003689,0.05302202,-0.016605344,-0.018561896,-0.051765256,-0.001012043,0.023239117,-0.020938931,0.019214455,0.008644672,-0.0019057741,-0.045634612,-0.08026837,-0.05659426,-0.0035063184,0.07347432,-0.039195213,-0.05588787,0.033517994,-0.07388241,0.06501998,0.028939277,0.03412087,-0.09963634,-0.009633208,0.108123206,-0.03232683,-0.057524823,0.08436195,0.054973565,0.05907934,0.054218285,0.0013040698,0.094472595,-0.09260493,0.03057593,0.023840742,0.03231067,0.023690144,-0.0031166745,0.07754798,0.01608311,0.034267597,-0.07293561,0.031069737,0.06673964,0.05101428,0.028885258,-0.010940605,0.028153427,0.022541426,-0.05564492,-0.01652094,0.07078553,-0.0027884734,-0.045387156,-0.010892222,-0.10656208,0.0061739925,0.060645085,-0.067764215,0.039483048,-0.10391029,0.011697102,-0.04863752,-0.06553154,-0.005207925,0.0001414376,-0.06514593,-0.056528848,-0.020361722,0.11151061,-0.111431144,-0.034666393,0.007835317,0.07080274,-4.150299e-33,0.051671594,-0.050239466,-0.0016314213,-0.10302954,-0.05746888,0.08043098,-0.019423693,-0.04006486,0.0079860715,0.054261222,0.059716463,-0.024600467,-0.024638478,-0.033883132,-0.038496446,0.00882456,0.031067936,0.057034247,0.015548942,-0.0050387066,-0.034250353,0.04465521,0.04628862,-0.005112239,0.035310607,0.060698256,-0.01818579,0.11406968,0.07320887,0.044011917,-0.007614399,0.003460119,-0.07684538,-0.10858476,0.0065349727,0.027078696,-0.02915956,0.011572405,0.06776784,-0.064450756,0.046930246,0.048335362,0.031849887,0.0889821,0.002845872,0.14331292,-0.1388287,0.025225345,-0.025214672,-0.03167185,0.011651696,3.1378746e-05,-0.06375905,-0.01565132,-0.022091463,-0.013146031,0.032525897,0.0043253503,-0.065255865,-0.02422023,-0.027672853,-0.03433737,0.045611028,0.023128804,-0.055954814,0.03440765,-0.012868701,0.07312661,0.06311159,-0.01567315,0.08327607,0.018173816,0.06729385,0.026310109,-0.047056038,0.034129057,-0.017303979,-0.05934037,0.04173872,0.016263831,-0.040638566,0.03479972,-0.0793905,-0.069792494,-0.034383476,-0.039083313,-0.008710512,0.076700404,0.027560443,0.0001312702,0.004626354,0.04958926,-0.02749044,-0.03377487,-0.00016953943,-3.4673274e-08,0.019024251,-0.11146618,0.0409279,-0.029271817,0.046394207,0.012766912,-0.014806078,0.03676223,0.0498548,0.042105343,-0.044174768,0.03350651,-0.030147325,-0.060951017,0.043210074,0.018561665,0.04023098,-0.009988622,-0.0112193255,-0.036962874,-0.019793503,0.026627958,-0.041530866,0.043809608,0.005431952,-0.13341041,-0.0029934782,-0.015086151,0.030102618,0.010407069,0.021118132,0.053969722,-0.035232406,-0.030358398,-0.10838571,-0.034726348,0.01343241,-0.06255349,-0.030176116,-0.032648433,-0.005095678,-0.009880812,-0.076122664,-0.03284818,0.016427236,0.014640268,0.009224991,0.05390641,-0.036749233,-0.059449498,0.048813734,-0.06655475,-0.00756277,0.024275424,-0.12762912,0.026143342,0.007378944,-0.04666157,0.04928193,-0.06021554,-0.0030162411,0.03761133,0.18076473,-0.017050419 +1.8.7.2,"The enzyme contains a [4Fe-4S] cluster and internal disulfide. It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC 3.1.3.11 (fructose-bisphosphatase), EC 3.1.3.37 (sedoheptulose-bisphosphatase) and EC 2.7.1.19 (phosphoribulokinase) as well as other chloroplast enzymes by disulfide reduction.",384,1.0,-0.08111283,0.013660567,-0.117116146,0.03852883,0.1155384,0.004672874,-0.056850176,0.06214748,0.030713001,-0.013326582,-0.010627371,-0.025232675,-0.051591847,0.016593482,0.0016962916,-0.017466424,-0.06298555,0.04777017,-0.006743396,-0.054966237,0.01890449,-0.05226816,0.010357286,0.011524049,0.052542258,0.03254731,0.050210264,-0.042974595,-0.023240391,-0.086861394,-0.046393175,-0.016086187,0.0738679,-0.0025811214,-0.040158823,0.13568139,-0.0016340213,-0.10984325,-0.015537341,-0.06528649,-0.010287791,0.02632385,-0.043153893,-0.01681699,-0.079345554,0.012821483,0.0054719597,0.07158916,0.010994476,0.004032602,-0.05467387,-0.023140792,0.049435668,0.058280453,-0.002143916,0.0071360697,-0.017428549,-0.004518531,-0.009004102,0.041379903,0.0427836,-0.06175472,-0.029565817,0.042369552,0.009033764,-0.033011116,0.026841251,0.012246881,-0.013881449,-0.042519137,-0.014790557,0.002160903,-0.0028737325,-0.012779159,0.057391234,0.011960642,0.04651439,-0.017377451,0.047308657,-0.010242633,0.010383575,0.03334966,0.05924704,0.113191284,0.02050346,0.006480467,0.0011489873,-0.037398875,-0.02780287,0.028570816,0.06495963,0.04217025,-0.017111287,0.0014179278,-0.074558295,0.07753064,-0.004773195,0.02023063,0.017217828,-0.043875884,0.01228582,0.0716835,-0.044258814,-0.082096756,0.00010321779,0.014101712,-0.042012,0.1032894,0.0077932016,-0.0031681536,0.08851469,0.0069619776,0.064108156,0.039989736,-0.03686595,0.07955492,0.040197883,-0.055488963,-0.050181564,0.008711404,0.008898511,0.0072832555,0.02647114,0.040875144,-0.077473864,0.02696509,-0.1267519,4.5023696e-33,0.06959653,0.018106295,-0.054394457,-0.023408234,0.030302227,0.01863889,-0.086836584,-0.007608941,-0.063007966,-0.044026066,-0.062317166,-0.06661339,-0.008969765,-0.068315975,0.027068658,-0.114471234,-0.041685276,0.024328839,0.050897002,0.022230497,0.041851457,0.07558227,-0.063234664,-0.0033591404,0.071164064,0.08892423,0.009821112,0.0351245,0.022451099,0.00032287388,0.049537335,-0.030432804,-0.073389396,-0.017765164,0.08004458,-0.0007865768,-0.033167835,-0.01777635,-0.07721929,0.04388043,-0.05800822,0.038586352,-0.04964407,-0.08306858,0.07174415,-0.10659448,-0.005407836,0.05717667,0.11955613,0.106534146,-0.00675855,-0.013679829,0.1275713,-0.068119496,-0.060384512,0.013437271,-0.00056293514,-0.03675639,0.05566337,0.03146374,0.009193146,0.049519524,-0.033809558,-0.0013443964,0.008236283,0.0036443307,-0.041505944,-0.03284388,-0.0022506635,0.09846177,-0.059431795,-0.020693468,0.018834496,-0.0026907788,0.07652162,-0.076542035,-0.059384506,0.0027089268,0.022035738,-0.03119258,0.07575922,-0.0063394853,0.07708097,-0.037493225,-0.040190756,0.026632335,-0.0009834771,-0.045575738,0.0067376345,0.028661523,0.050252322,-0.06073308,-0.050197966,0.0014295722,-0.02148095,-4.015181e-33,0.093825035,-0.07529429,0.110177204,-0.051834624,-0.08011374,0.06828235,-0.008656103,-0.013800969,0.03661447,0.004017837,0.123395294,-0.018881708,0.003741043,-0.042388275,0.053125557,0.033302266,0.014785329,0.011105167,-0.02080573,-0.025087647,-0.0069831493,0.062826835,0.038718425,0.039320536,0.08021862,-0.013266316,0.0031844948,0.04982724,0.12077961,-0.02373205,-0.058649667,-0.020892544,-0.011584947,0.0048997537,-0.025833193,0.010332212,-0.09289081,0.05061851,0.014530758,0.025125163,-0.012043454,-0.01617026,0.04256126,0.033724762,-0.013735433,0.024078965,-0.11347339,0.050476145,0.0051429463,-0.002502595,-0.01355349,-0.019209929,-0.08979882,0.11277248,0.039821833,-0.0144055765,0.014347603,0.046374854,-0.037339177,-0.012120136,-0.032477986,-0.12833288,0.04948119,0.017827641,0.08473309,0.013627234,-0.08620147,0.043598928,0.03351041,0.038100034,0.035151437,-0.013657122,0.039460547,-0.072980516,0.0030704322,-0.010473226,-0.042643074,-0.015939035,-0.012950734,-0.0032757348,0.007880326,0.035014518,-0.010523544,-0.049659163,-0.016365964,-0.08036505,0.044417188,0.11151812,-0.009110602,0.05697367,-0.027034465,-0.020545905,0.00440206,-0.009785558,0.090642594,-4.4034255e-08,-0.031371314,-0.058542095,-0.0049664825,-0.07795661,0.0040223384,-0.033723984,0.026482057,0.004013166,-0.016226506,0.011761619,-0.022659993,0.13101177,0.023606833,-0.07402865,0.05415365,0.007955904,-0.037988093,0.006900398,0.01638719,0.037178613,-0.039136373,-0.08601877,-0.13843127,0.07054089,0.020673908,0.0128278695,0.032595318,-0.024461146,0.043296356,-0.023000201,0.0038937612,0.0093099745,0.02635273,-0.036219954,-0.07492954,0.004708557,-0.11210095,-0.008906557,-0.087254085,0.033152886,0.03379178,-0.049621303,-0.005318287,0.053704973,-0.062023673,0.02322815,0.06451214,0.052467115,-0.034773882,0.043719143,0.030094327,-0.03692172,0.009439122,-0.076717876,-0.13340634,0.025095528,0.030382922,-0.033197977,-0.0280971,-0.040078647,0.035312235,0.004857884,0.19400932,-0.004202155 +1.11.1.18,"Bromoperoxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate. They catalyse the bromination of a range of organic molecules such as sesquiterpenes, forming stable C-Br bonds. Bromoperoxidases also oxidize iodides.",384,0.99999994,0.002239679,0.0043234373,-0.089106664,-0.009402877,0.032794096,0.08033325,-0.042887777,-0.06374709,0.034191165,-0.007157039,0.031901956,-0.09832839,-0.027412951,-0.05006847,0.0014781088,0.03377714,-0.026483454,0.03142713,-0.07413588,0.07856015,-0.002385732,0.015308791,-0.0894121,0.04619443,0.070936166,0.09714298,0.008828362,-0.028502714,-0.039002795,-0.08669924,-0.024070188,-0.012512504,0.06559892,-0.013260381,0.06962773,0.028989716,-0.04790879,-0.067232326,0.057299886,0.018183729,-0.068865485,-0.010563715,0.07455501,-0.020230865,-0.07176147,-0.02011152,0.035842665,-0.03346554,-0.03273356,-0.02803892,-0.000787015,-0.022017859,-0.05467954,0.017373286,0.016785188,0.05368448,-0.021351028,-0.014459343,-0.014799996,-0.013578455,0.069979556,-0.031734087,-0.016393984,-0.027491827,-0.08664363,-0.03534761,-0.004038758,-0.018888917,-0.035712384,-0.059563186,-0.0209198,-0.064274244,-0.05675142,0.05553102,0.01498827,0.045832288,0.036374304,-0.122336216,0.018587343,0.012913697,-0.020385055,0.044912197,0.0032615873,0.075986914,0.0750529,0.022262849,0.041783437,-0.04731705,0.026306847,0.025948599,0.041707326,0.06490968,0.0029437623,-0.07948453,-0.07121729,0.045808606,0.082797624,0.056333177,0.010935376,-0.03585771,0.022213016,0.038725406,-0.059734304,-0.139616,-0.05266502,0.022903955,0.018025374,0.0424765,0.020511247,-0.02053694,0.017329954,-0.036495097,-0.0028246064,-0.009182097,-0.019575002,0.13805689,0.07910772,-0.07479417,-0.095141925,-0.038253818,-0.022147633,-0.0677114,0.060837723,-0.0074236346,-0.06966299,-0.03867248,-0.045445435,4.991005e-33,0.066814765,-0.039292824,-0.036622472,0.062374085,0.05257085,-0.03789887,-0.11767542,-0.050076716,0.019836992,-0.101336956,-0.12092129,0.06043968,-0.020330252,-0.021335095,0.008454184,0.031746034,-0.059043963,-0.028726466,0.00954626,0.0041907723,0.016617399,0.018432371,-0.020818787,-0.0095722405,-0.015131528,-0.031497546,0.06598918,-0.07877279,0.039181553,0.0021374398,0.030863585,-0.022676919,-0.010122386,-0.033661056,0.007028514,0.043514024,-0.09470978,0.012410714,-0.10260158,0.015556491,0.022123847,0.055175666,-0.12471256,-0.012776627,0.023830207,-0.08892414,-0.042611673,0.013905862,0.04206578,0.0687234,0.017185684,-0.018201206,0.0037709314,0.024964025,-0.016653426,0.059225604,0.023601128,0.027473195,0.0423274,0.04459348,-0.040099155,0.0050163013,0.008698762,0.007225466,0.089203455,0.069495775,-0.034199648,0.008245872,-0.0044175517,-0.038885243,-0.027969377,-0.058402855,0.09772583,-0.025574395,0.025380326,-0.057678126,-0.04537542,0.0042654774,-6.22757e-05,0.012135839,0.10782392,0.006233134,0.08052314,-0.06613488,-0.05507792,-0.02636533,-0.0061727846,0.013844732,0.030664112,0.023498489,0.05905842,-0.10222398,0.021883031,-0.09681561,-0.005161249,-5.7609494e-33,0.10292749,-0.14671826,-0.027781902,-0.02983288,0.01022382,-0.001564023,-0.041148264,-0.035194095,0.029862037,-0.0479335,0.072412126,0.039652422,0.058726218,0.03991927,0.057895485,-0.084655836,0.08607924,0.064315274,-0.0072800065,-0.0027933344,-0.060232796,-0.022848448,0.032142006,0.101759434,0.04252557,0.005233783,-0.10749161,0.004896161,0.071307756,0.025499394,0.011340797,0.04137485,0.03138132,0.007553582,-0.04345121,0.04171461,-0.026200052,0.034120847,0.006428139,0.10561921,3.0763767e-05,-0.03816928,0.017029164,-0.014493818,-0.008194576,-0.015661255,-0.1153227,0.008711067,-0.01495019,-0.06302181,0.073036596,0.030837823,-0.049057268,-0.03166931,0.104450315,0.062210556,-0.031280365,0.041784752,0.029627502,0.01220788,-0.093484454,0.023469362,0.008881293,0.01669082,0.012114034,0.09033236,-0.073247634,-0.027151212,-0.0034813124,0.03569301,0.03674532,0.07509919,0.044776697,0.018173492,0.047322787,-0.098644584,-0.030158097,-0.0013139831,-0.0066477996,0.01771211,0.007800388,-0.008676252,0.027801935,-0.055583782,-0.0833813,-0.08447563,-0.042059053,0.07401864,-0.0023446467,-0.02095602,0.01422,-0.037820574,0.015899565,0.10403103,0.14391339,-3.4984893e-08,0.0108878985,-0.0058242558,0.053302497,0.027588248,-0.006393905,0.060917255,0.08319159,-0.00694869,0.08923347,-0.07146199,0.060829878,0.052653767,0.03228875,-0.057829544,0.029337104,0.05168077,-0.0035773374,-0.03843003,-0.0007995358,0.06351976,0.005750747,-0.018702881,-0.012659617,0.027551372,0.019367779,-0.00683072,0.0048725577,0.007415442,-0.038669135,-0.0037877436,0.064282104,0.0061476706,0.024570992,-0.017445274,-0.05207982,-0.0239037,0.049183775,-0.024725396,-0.04774439,0.019541115,-0.029552903,-0.06491186,-0.10001619,-0.036334,-0.030167008,0.090018936,-0.008169344,0.017800067,0.0020331296,-0.020573797,-0.015448085,-0.033552684,0.021073604,-0.040237334,-0.08992317,0.062012743,0.06446389,0.012384087,-0.010011077,-0.055081412,-0.050605558,0.05205411,0.15703346,0.034144465 +1.14.11.29,"Contains iron, and requires ascorbate. Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.",384,1.0,-0.031043265,-0.016367093,-0.045249622,0.066301174,0.12755886,0.017601749,0.039775766,0.022207871,-0.025046568,-0.015786791,0.005822039,0.021810044,-0.05631273,-0.030476399,-0.013337101,0.06557701,-0.07943423,0.0008339368,-0.04422529,-0.03462734,0.053699967,0.0137661155,0.04983603,0.022528542,-0.030162938,-0.043572575,0.010519012,0.035522066,-0.01540189,-0.06774799,-0.00026560735,0.0011350746,0.05710331,-0.06935801,0.0072808624,0.09000385,-0.0065517775,-0.09847683,-0.05849406,0.056511506,0.028601654,-0.049401823,-0.046364132,0.07954935,0.005027312,-0.01800464,0.04070189,-0.02517163,0.039453406,0.09276297,-0.07230034,0.002528042,-0.033050325,0.025797235,-0.077235274,0.021310965,-2.446755e-05,-0.056236766,-0.007630127,0.030770438,-0.09352655,-0.010109366,-0.04177629,-0.019775292,0.06414192,-0.023986038,-0.013477035,-0.027142964,-0.07343174,-0.049664207,-0.003511357,-0.066282526,-0.033818502,0.05509296,-0.05275531,0.03872437,0.006160743,-0.07824246,0.08956198,0.009907637,0.027134025,0.012017596,0.06278509,0.10115572,0.063873015,0.033713583,-0.021036323,-0.098868564,-0.101685144,0.051633988,-0.040436156,-0.022304578,-0.0014382614,0.01437216,-0.0082067875,0.03227272,0.058214445,0.01067817,-0.0013493763,0.0053900103,-0.08163028,-0.020247761,-0.013701773,-0.036550857,-0.012845164,0.014658029,-0.021819921,0.11166147,0.07962653,0.07042781,0.0015696314,-0.06950117,0.056446135,0.008981949,0.075367056,0.08115132,-0.0035934718,-0.034624297,-0.048346195,-0.10463532,0.03151756,-0.006663147,0.03397491,-0.028875923,-0.05305657,-0.024701398,-0.013042341,1.878026e-33,0.11682863,0.038096912,-0.010916994,0.04010915,-0.09524243,0.001373424,-0.10039306,-0.0404925,0.015363519,-0.010896952,-0.051620066,-0.022693675,0.016799647,-0.015724402,-0.069988616,-0.14636691,0.01110965,-0.027370479,0.06666924,0.02029324,-0.0039492766,0.046779092,0.017380865,-0.015682526,-0.03774925,-0.037913844,-0.032786608,0.013272254,-0.010879069,0.016630476,0.01199352,-0.12483155,-0.04799612,-0.0009369838,-0.0028519912,-0.032310247,0.002331385,-0.07094657,-0.0479341,0.04896033,-0.01610756,0.048526734,-0.019253403,-0.076909885,0.08995715,-0.089159444,-0.018450877,0.100794725,0.0091455905,0.044853512,0.012506759,0.03599849,0.07783801,-0.0036245724,-0.051323865,0.00614435,-0.046685517,-0.06496019,-0.00096162787,0.096974894,0.00028755833,0.03099895,-0.009102572,0.097418025,0.037428454,0.0026101058,-0.021165397,-0.010115517,-0.024579499,0.035714503,-0.015377964,0.033641256,0.07466165,-0.029357726,-0.09208437,-0.010727213,-0.05434632,0.10707346,0.057715476,-0.023592452,0.042817283,0.0287016,-0.011854327,0.116518326,-0.00010284836,0.033217568,0.046400942,-0.012707163,-0.014118776,-0.06651937,0.081224956,-0.07926432,-0.015145534,-0.12921926,0.061355468,-2.4300776e-33,0.08389966,-0.10018492,0.013619865,-0.079364434,-0.0034011127,0.105889976,0.059081573,-0.024437524,-0.0028153977,0.012877737,0.053318307,0.016038919,-0.035008468,-0.1337619,0.046476167,-0.06563147,-0.056056976,0.06602613,0.008848138,-0.004173186,0.05112259,0.009119329,-0.00778041,0.06614615,0.046066552,-0.023647174,-0.05084269,0.012841304,0.055147246,0.057019748,0.0119947465,0.057913948,-0.018206555,-0.02889398,0.04176367,0.028499074,-0.06647782,0.085745215,-0.057697073,-0.08620937,-0.00016464588,-0.055467,0.022879373,0.039994434,0.07897124,0.11808908,-0.0805052,0.018677387,0.008813853,0.072257854,0.012124607,-0.013304942,-0.04174102,0.015469918,-0.008897345,-0.002583204,-0.020453881,-0.0012333586,0.01817828,0.0251841,0.024506865,0.04450309,0.023821944,0.01647192,0.024954183,-0.0014995277,-0.009776569,-0.011820208,0.06480245,0.023284694,0.07250323,0.05027439,0.04358227,-0.011539082,0.016984906,0.045392685,-0.023151234,0.0063021444,-0.048470523,0.08525662,-0.02663771,0.024256593,-0.028506605,0.0006095862,0.013502455,0.004686878,-0.028126484,0.028306276,0.005922643,0.0061741904,-0.029879656,-0.055381984,-0.09760557,-0.000111436326,0.021567931,-3.548715e-08,-0.066480435,-0.02051796,0.068766505,-0.07720106,-0.0370985,0.055438697,0.0767375,-0.015532103,0.046119,-0.021739198,0.03396886,0.11570256,0.029660558,-0.05430795,0.05814581,-0.0069917077,0.07000069,0.0941579,-0.03966226,0.00259012,-0.042885803,-0.048975293,-0.033025477,0.059317846,-0.02864036,-0.12907688,0.0020324923,0.035659403,0.025499033,-0.033010006,0.05305893,-0.0096897865,0.018356066,-0.06985007,-0.035118468,0.0117864115,0.048861,-0.0017726066,-0.035986613,0.008358659,-0.07125903,-0.023116257,-0.03856573,-0.027207768,0.04509929,0.015219189,-0.020283386,-0.02148921,-0.0107596945,-0.011652552,-0.052165914,-0.026569128,-0.03442388,-0.041980475,-0.11173096,0.086008616,0.00020451115,-0.016087444,0.023315907,-0.0657675,0.043038927,0.020288145,0.19227609,-0.04932365 +1.14.11.30,"Contains iron, and requires ascorbate. Catalyses hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia. ",384,1.0,-0.06391077,-0.022095349,-0.06821373,0.100036785,0.0984692,0.008596046,-0.018836072,0.00520076,-0.017365342,-0.051278427,-0.006110347,0.0010713883,-0.03810731,-0.039130446,-0.038279805,0.045636762,-0.05832085,0.03161088,-0.03639106,-0.06787012,0.013496609,0.0072962157,0.0981717,0.0036824485,0.006496397,-0.021948954,0.010562103,-0.012750529,-0.03241258,-0.06852546,-0.0067708706,-0.008332175,0.065873496,-0.064991504,0.008713816,0.10185497,-0.020378344,-0.124807715,-0.0070862547,0.04072098,0.013023449,-0.053365957,-0.034495987,0.072828084,-0.03671508,-0.028784562,0.025108818,-0.041282143,0.05767694,0.058069885,-0.074472,0.02539611,-0.07198381,-0.010658984,-0.086234204,0.021698913,0.0038698055,-0.046150815,0.033218298,0.019919379,-0.081421815,-0.016935654,-0.043503843,0.025279744,0.060776193,-0.041118108,0.0117665725,-0.036450904,-0.08003435,-0.057586852,-0.012750734,-0.060531527,-0.038405273,0.022926906,-0.055220537,0.022508493,0.020833507,-0.060633108,0.086829275,0.05658763,0.048182394,-0.012867501,0.04948142,0.10663631,0.043582134,-0.004279602,-0.052213695,-0.07243424,-0.06180042,0.08180532,-0.054432973,-0.027918685,-0.0074274647,-0.0063783024,-0.0038143802,0.015601831,0.11736075,0.023985786,-0.03278372,-0.010145893,-0.08904551,0.0021439283,-0.049114022,-0.0010662919,0.04075324,0.0014016483,-0.027271809,0.08779855,0.10439193,0.0636256,-0.038790356,-0.076343045,0.034655232,-0.035272412,0.031121865,0.11792215,0.024170471,-0.048363745,-0.04116124,-0.08925532,0.025636382,-0.017693203,0.0028643836,-0.04962044,-0.03199829,-0.053141665,-0.03355458,2.4495278e-33,0.12760748,0.07761103,0.0011997593,0.03991844,-0.076889634,0.029729927,-0.0737499,-0.032777034,0.0044209603,-0.027535385,-0.060874213,-0.036545813,0.0032289734,-0.015333459,-0.07058304,-0.14143686,0.009606881,-0.0092655,0.05748709,-0.023409236,0.012308459,0.016284695,0.01582001,-0.008940306,-0.013879828,-0.06503414,-0.03898751,0.019609405,0.008724772,0.013486366,-0.0028177188,-0.07781829,-0.055492304,-0.0662371,0.021109022,-0.054094207,0.013493315,-0.06584395,-0.047873102,0.035173465,-0.037722733,0.034158666,-0.037993077,-0.08655877,0.059046105,-0.096323155,-0.035342574,0.09422059,0.02475649,0.07443397,0.009583749,0.03589042,0.081594266,0.023274831,-0.038785674,-0.005656077,-0.04942861,-0.07537182,-0.016222823,0.10836596,0.0364403,0.022848219,0.041557685,0.09339883,0.062361665,-0.010571176,-0.03604425,0.0072213523,-0.0011901426,0.11468765,-0.031546794,0.005763591,0.048405934,-0.020458266,-0.057134986,-0.0097470675,-0.067068666,0.0968047,0.039716,-0.04560892,0.06282501,0.00971581,0.016232917,0.11654667,0.04195591,0.020734195,0.013078649,0.014039333,-0.010954676,-0.06540239,0.036818337,-0.09869663,0.009723786,-0.08973165,0.0756816,-2.5137662e-33,0.0729932,-0.0762131,-0.0046501164,-0.084077545,-0.017706871,0.07166981,0.10030275,-0.009759254,-0.024490668,0.027556598,0.058250044,0.07249577,0.011315775,-0.14696312,0.038575795,-0.04915548,-0.031277362,0.09876708,-0.004008689,0.022587389,0.051523823,0.003242797,-0.06477401,0.072856784,0.036791727,-0.021968212,-0.08909941,0.0053493665,0.035119034,0.029461788,0.0065443455,0.060027596,-0.005308851,-0.0040080287,0.0506328,0.03481833,-0.04182043,0.06922748,-0.060154654,-0.04011838,0.01681368,-0.05386642,0.007985375,0.07671352,0.078750305,0.100411445,-0.066833414,-0.0047198464,-0.003013135,0.041554093,0.0046245917,-0.021855118,-0.04041179,0.044080224,0.023116643,-0.003980589,0.0068567516,-0.012773662,0.01784507,-0.010166122,0.036171213,0.10157425,0.07771452,-0.034862313,0.019129492,-0.013140743,-0.022182053,0.01206277,0.04751293,0.015843831,0.050851002,0.011990628,0.071180716,0.011240816,0.02722786,0.005513114,0.0030563117,0.03631203,-0.014692922,0.10775054,-0.011254355,0.0336999,0.0068286923,-0.012468971,0.012514316,-0.0135531975,0.00072263187,0.030732265,0.034299545,0.015255929,-0.032659173,-0.048317153,-0.07601278,0.04501239,0.03190059,-3.630747e-08,-0.06123296,-0.027978538,0.046716325,-0.04865045,-0.032880798,0.06399726,0.059970297,-0.0294319,-0.015411954,-0.022600185,0.056260142,0.058122434,0.041087136,-0.050773118,0.063096285,-0.026776142,0.050159868,0.099846065,-0.017541911,0.037211597,-0.037512116,-0.016228186,-0.00030625463,0.05351957,0.02458115,-0.121494785,-0.027976489,0.033279724,0.030090751,-0.042861238,0.06338255,0.008762908,0.024679312,-0.043381218,-0.05711416,-0.024154307,0.08108183,-0.01305435,-0.052876413,0.013211697,-0.059337206,-0.02643497,-0.043636214,-0.01818217,0.009563451,0.07655938,-0.001001769,-0.020597989,-0.009609246,0.015605226,-0.028704863,-0.010124186,-0.040026423,-0.030767001,-0.08440744,0.053133167,-0.03858603,-0.021895848,0.010970364,-0.09594807,0.028632281,0.016852861,0.16314387,-0.06521571 +1.14.11.31,"Requires Fe2+. Catalyses a step in morphine biosynthesis. The product neopinione spontaneously rearranges to the more stable codeinone. The enzyme also catalyses the 6-O-demethylation of oripavine to morphinone, with lower efficiency. ",384,0.99999994,-0.025106184,-0.050348047,-0.025078498,0.052491456,-0.011086525,-0.022812042,-0.07707587,0.023221754,0.032765754,-0.02628666,-0.010587128,0.045088798,-0.07302001,0.033322144,0.0095767025,0.097643696,-0.08223637,0.031767625,0.023961231,0.06423372,0.14439978,-0.04018963,0.061198253,-0.0054540234,-0.035339154,0.07289582,0.055623487,0.041964915,0.04584795,-0.051049124,0.06225624,-0.039429326,0.036772463,-0.02469701,-0.008477346,0.025641857,-0.0040231496,0.01494213,0.03317628,0.034311783,-0.048207916,-0.0465473,-0.055993784,0.002080629,0.031173283,-0.13879141,0.018143099,-0.054195818,-0.011348781,-0.018249413,0.032507345,-0.043891538,-0.05945522,0.03520557,0.051114798,-0.041145597,-0.003761906,-0.022120358,-0.015164869,0.010420955,0.029629532,0.061983857,-0.023252312,0.033444494,-0.009034503,0.014531934,0.024136243,-0.030782491,-0.04612454,0.026250662,-0.003750684,-0.045919027,0.011821475,0.025159389,-0.008302352,-0.007484333,0.054163504,-0.029284963,0.018453611,-0.05011042,0.03856954,-0.011405748,-0.0015561787,0.16466743,0.040865585,0.044766925,0.0050517903,0.01793489,-0.012957849,0.043649577,0.019473502,0.058317818,-0.049476102,-0.03923941,0.02300694,-0.037944008,0.007965405,0.011046052,-0.025412736,0.024353398,-0.033421356,0.08667197,-0.10096934,-0.08294648,0.012318488,0.024891742,0.019398693,0.043316443,-0.026228288,0.04359474,0.039322548,-0.026661003,0.07828543,0.06480738,-0.05461472,0.108334735,-0.0032515104,0.036301605,0.00064500363,-0.011376829,0.016659819,-0.002478515,-0.074053265,0.10214107,-0.06596489,0.029215017,-0.039491598,4.1705228e-33,0.05138556,0.038294032,-0.011221749,-0.0044010393,-0.07571937,0.040143847,-0.019698631,-0.04090339,-0.03218903,-0.021464767,-0.03279584,-0.11452399,0.047527242,0.07528984,-0.008864393,-0.10812464,0.019078327,0.005301063,0.011614233,-0.054005276,-0.04715402,-0.002176245,-0.04965725,-0.025090983,-0.011507639,0.099906914,-0.04593298,-0.008159571,0.03588734,-0.031883076,0.036280084,-0.019652542,-0.016800994,-0.01571211,0.04437748,0.00401523,0.020993441,-0.045569684,-0.0796968,0.010406106,0.012600582,0.06261579,-0.03042583,-0.030135397,0.08431078,-0.034301177,-0.061069403,0.1240389,0.035640776,0.111965865,0.018089294,-0.00811827,-0.006359974,0.009533115,-0.08501799,-0.03551074,-0.06618061,-0.06273838,0.08774111,0.048930917,0.026892163,-0.027626716,0.075278334,-0.02853236,0.027933694,0.02672939,-0.0349326,-0.04973177,-0.047418322,0.1696114,-0.06622774,0.03743154,0.008981903,0.035638817,0.007462413,0.03494101,-0.0731614,-0.037055768,0.03152312,-0.03924384,-0.038200732,-0.08499964,0.008569658,-0.012419471,-0.01346457,0.017140158,-0.049040932,-0.0636506,-0.028517798,0.114923514,-0.049800362,-0.08053199,-0.09088292,-0.043025155,0.0387319,-4.521625e-33,0.020971585,-0.08071266,-0.0071754195,-0.05382679,-0.058423802,0.017425261,-0.07306697,-0.10044384,-6.075643e-05,0.054087672,-0.020403892,0.002546078,0.099579,-0.061407134,0.070817634,0.018578796,-0.051472027,0.07058523,0.0860301,0.019461509,0.014522883,0.10898936,-0.09671984,0.113024786,0.054711763,0.06681824,-0.043531794,0.04342137,0.07441074,0.013786538,0.015425653,-0.013640769,-0.048903227,-0.059811797,0.0152131915,0.15621404,0.02234747,0.0045791734,0.025573686,0.03765701,-0.107024714,0.011779807,0.02647217,0.059950538,0.024128279,-0.032679748,-0.017111385,0.0353283,0.064305924,-0.049940087,0.02824165,-0.020934701,-0.01913518,-0.00084264297,0.014321264,0.0130762635,-0.018034765,-0.1102115,-0.021376403,-0.067822725,-0.0075380392,-0.020634938,0.05616664,-0.05001915,-0.02858844,0.032816656,-0.0033850328,0.029792331,-0.024386955,-0.025366709,-0.012449575,-0.0007960291,0.055099968,0.019574217,-0.032447163,-0.036771104,-0.039601203,-0.108761124,-0.028561726,-0.0093797175,-0.027605472,0.034486644,0.023915846,-0.028978063,-0.107412964,-0.022012003,0.06737977,0.08270702,-0.06875033,-0.0256822,0.024060134,0.0018312371,0.0024451767,0.04428373,0.028688991,-3.7201158e-08,-0.007291557,-0.089057565,0.078913264,0.024668239,-0.008902742,0.04633182,0.031820726,-0.033336956,-0.055757716,-0.041417316,0.023333732,0.06099853,-0.0009809502,0.015186087,0.047321275,0.034467034,-0.06328032,0.06494763,-0.053726494,-0.017536638,-0.0897159,-0.024986358,-0.08519861,-0.016896501,-0.006816568,-0.053971816,0.035109304,0.053611167,0.032093767,0.04015851,0.09965004,0.007838574,0.009734968,-0.015729332,-0.059941486,0.00941227,-0.009671824,-0.04260103,0.010684969,-0.0252494,0.023781328,0.00041179045,-0.035031084,0.015511647,0.0035685576,-0.018017376,0.0021224811,-0.028902028,-0.0654044,0.025860347,0.04528556,-0.048488434,-0.0010426574,-0.039462164,-0.036583606,-0.0011546472,-0.049877077,-0.020003874,0.042150453,-0.00665137,-0.030390646,0.013259029,0.2441206,-0.067664444 +1.14.11.32,"Requires Fe2+. Catalyses a step in morphine biosynthesis. The enzyme also catalyses the 3-O-demethylation of thebaine to oripavine, with lower efficiency. ",384,1.0,-0.0225578,-0.033601888,-0.02057228,0.060725637,0.025826614,-0.01881851,-0.09569177,-0.0017928533,0.048386257,-0.012457278,-0.033985008,0.004231318,-0.05598536,0.05944303,0.04543484,0.057484798,-0.06475533,0.02524303,0.018546598,0.029544936,0.14550602,-0.009553031,0.078324735,-0.025819993,-0.042484198,0.05529613,0.062081542,0.0039948765,0.04628776,-0.03656415,0.05430829,-0.076005235,0.050867323,-0.07142619,-0.012694019,0.036180627,-0.031188337,0.007337365,0.02325743,0.017726235,-0.04352894,-0.064854935,-0.08425926,0.01574642,-0.0071774316,-0.15587416,0.017696872,-0.079914376,-0.0041522547,0.0011322419,0.035129,-0.018920483,-0.06734136,0.043660317,0.05060442,-0.04228692,-0.0330898,0.02896442,-0.03849325,-0.014624396,-0.0042745234,0.04233498,-0.04230904,0.045507375,-0.0065192687,0.015691927,0.035176236,-0.04391947,-0.049089767,0.039503615,-0.026508935,-0.05768838,0.027922252,-0.010892944,0.010491544,-0.030579891,0.06258011,0.0073135956,0.008862783,-0.025460683,0.03339924,0.009267723,-0.009369146,0.16277812,0.03899926,0.039242227,-0.022096539,-0.0067122164,-0.018500281,0.031484377,0.019530699,0.057049457,-0.0648515,-0.015422604,0.049707837,0.010115899,0.025849339,0.022269689,-0.018743465,0.017888535,-0.035202686,0.12505962,-0.11159889,-0.048424155,-7.530642e-05,0.022873783,-0.02342999,0.03374045,-0.03943436,0.06317218,0.061052024,-0.029918674,0.0834347,0.06690105,-0.04270114,0.08432725,-0.018512027,-0.004112592,-0.0020095403,-0.0459779,0.02037227,-0.020790696,-0.067065135,0.12940885,-0.041604456,0.032760154,-0.027071742,1.6871622e-33,0.050936405,0.0543339,-0.01931772,-0.040011805,-0.05659053,0.022227377,-0.02107612,-0.0015922872,-0.020727726,-0.00097589835,-0.043787114,-0.10651895,0.049552787,0.04584302,-0.016279366,-0.12415438,0.013067443,-0.0055073993,0.03742688,-0.032707375,-0.016893491,0.0042779907,-0.031688765,0.017591963,-0.03552555,0.078709014,-0.015198626,-0.025908098,0.04007138,-0.040970813,0.050618276,-0.05731807,-0.01976844,-0.006932745,0.0249487,0.0044374145,0.019674689,-0.038343973,-0.07020103,0.00451439,-0.0024887703,0.05316664,-0.009334458,-0.037804767,0.055789985,-0.012301263,-0.05405611,0.093789645,0.039298516,0.1251588,0.047466636,-0.019627914,-0.0032453353,0.009354573,-0.10197584,-0.020943515,-0.052514885,-0.0670754,0.076555334,0.026898013,0.011816495,-0.025446583,0.11346881,0.0008599045,0.029363832,0.0010917891,-0.03145807,-0.031151533,-0.010718059,0.13914452,-0.07886011,0.04840276,0.015353613,-0.0011935838,0.030482024,0.042588525,-0.057503477,-0.035449874,0.056516346,-0.016544826,-0.02761606,-0.08912558,0.015785294,-0.0064768316,0.015825177,-0.02043528,-0.0633511,-0.05554332,-0.012713142,0.08155959,-0.05138394,-0.042245153,-0.09989036,-0.02801788,0.059357774,-2.8167201e-33,0.05469034,-0.08679187,0.011969796,-0.07415381,-0.06261433,0.039460532,-0.08575386,-0.117806144,0.025816383,0.0678633,-0.017764412,-0.0009993876,0.098570734,-0.07417629,0.031128928,0.027719038,-0.05691261,0.048680093,0.04466242,0.037850607,-0.0039375434,0.104579754,-0.065438144,0.13983232,0.07370828,0.0610132,-0.010492623,0.02002858,0.047426358,0.036256734,0.017527666,-0.0040150564,-0.034873784,-0.06654937,-0.012285937,0.14556767,0.013112949,0.024883043,-0.010690644,0.02033416,-0.06732784,0.010283147,0.025339836,0.044480924,-0.008027648,-0.026887571,-0.029669017,0.044105306,0.050080806,-0.031305365,0.03734113,-0.017445805,-0.033713557,-0.006279484,0.04637649,0.01385719,-0.0050833505,-0.1206063,0.011224449,-0.0826222,-0.020165844,0.016238451,0.03931895,-0.029589165,-0.028721318,0.021950724,-0.025504304,0.024689218,-0.000104339066,0.010093029,-0.0069007273,0.0020598657,0.064210355,0.012957796,0.007369844,-0.039629128,-0.035128485,-0.102258496,-0.027552655,-0.006468583,0.0040020347,0.048404787,0.0328635,-0.065708436,-0.12227089,-0.041051425,0.065308444,0.10580559,-0.047079697,-0.016695375,0.015333253,0.020795643,-0.0053084115,0.05404016,0.03759705,-3.2958763e-08,-0.032386545,-0.05611486,0.06173495,0.021478321,-0.037685856,0.03988429,0.045280736,-0.023248725,-0.057455212,-0.03145552,0.015401581,0.034719862,0.0014280095,0.008479412,0.06797118,0.03177586,-0.023579178,0.06969839,-0.06511578,-0.049955025,-0.10490103,-0.029148092,-0.09828385,-0.01476514,0.052016117,-0.027356591,-0.0077946982,0.016363157,0.051144525,0.030634938,0.08140077,0.00795626,-0.014122855,-0.02135761,-0.057053898,0.010347491,0.034835763,-0.045878712,-0.00036901573,-0.0300693,-0.020763887,0.007943506,-0.028073715,0.009672428,-0.021581579,0.004162801,-0.018283637,0.0073882714,-0.047603104,0.024309155,0.038190644,-0.07707471,0.014472356,-0.07560665,-0.057103924,0.008663087,-0.0480132,-0.019030346,0.030121675,-0.02703271,-0.0058508026,0.010325764,0.25853646,-0.06847348 +1.14.13.115,This P-450 monooxygenase enzyme is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.,384,1.0,-0.09584917,-0.046544027,-0.08684868,0.034104303,0.07414493,0.058369607,-0.11708867,-0.0033159007,0.038421232,0.023933178,-0.008312381,0.007578578,-0.11705118,0.000995732,-0.034610916,0.060290303,-0.09537877,0.006464324,-0.016945269,0.03605527,-0.026367394,-0.032030664,0.034597274,0.067040205,0.016815295,0.037035383,0.05500469,0.060672402,0.0019648953,0.03217986,0.021949526,-0.017136399,-0.0243107,0.012053081,-0.026055016,0.022098744,-0.06655137,-0.06914548,0.02830513,-0.05862957,0.030429885,-0.019319281,-0.04164011,-0.06303306,-0.032738704,-0.054463163,-0.04585924,0.01832007,0.06224352,-0.028279873,-0.012893533,0.0075846305,-0.073453836,-0.04978871,-0.018763354,-0.050406978,-0.0072675054,-0.042988546,0.0067976033,0.021638406,-0.00994124,0.023917276,-0.05584786,0.07580066,0.021833815,-0.039060168,0.004830333,-0.020777049,0.01270576,0.019833539,-0.07322822,-0.09114973,0.021378275,-0.10265268,-0.053970087,0.09663262,0.037325934,-0.051859587,0.04919522,-0.02526253,0.053661786,0.05516118,0.06846435,0.09135148,0.009122979,-0.015331982,0.040690895,-0.012001082,-0.020486476,0.004816776,0.0035430877,-0.0025424275,0.0119220195,-0.036607552,-0.025213439,0.09765051,0.05112251,0.03704511,-0.015544302,-0.009487547,-0.01650229,0.037074856,0.043194633,-0.08386301,-0.04528554,0.057369467,-0.030184466,0.096501306,0.0750365,-0.036446795,-0.033564996,-0.014980937,-0.10905739,0.013756079,0.045439713,0.10723922,-0.014646937,-0.1149356,-0.05258782,0.0696371,-0.003959367,-0.051844437,0.021958295,0.029807234,-0.060364258,-0.018096516,-0.011199479,-8.872431e-34,0.062256858,0.0042666267,-0.03566921,-0.03454796,-0.009785151,-0.0010200572,-0.053447053,-0.02140494,-0.057266116,0.0091533745,-0.01670764,-0.062583916,0.06774541,0.008095047,-0.086842194,-0.05021069,-0.033222284,0.011489102,-0.005122195,0.044635013,-0.013129768,0.006411248,-0.02224151,-0.007258497,-0.04242111,0.14061907,-0.09610904,0.06831477,0.036496207,1.49262605e-05,0.066715166,-0.027238322,-0.08838304,0.027784383,0.07140855,0.039890654,-0.04176297,-0.033221275,-0.039923485,0.09715524,0.0024789139,-0.0693612,-0.066724375,-0.053704716,0.07408835,-0.025419649,-0.09990694,0.028002126,-0.04299653,0.03803324,0.026860207,-0.008624186,0.083445065,0.018039884,0.04165982,-0.038672097,0.012497668,-0.022816438,0.06413009,0.02480103,0.015817627,-0.045295294,-0.024394816,0.07848304,0.043979608,0.009578018,-0.009542406,0.012462116,0.025323445,0.10024412,0.020706326,0.020747127,0.041201387,0.047099285,0.066683464,0.031386647,0.05620371,0.11496172,0.007197568,0.038948677,-0.01679936,-0.0033230674,0.0566786,0.0071370034,-0.026158722,0.016709069,-0.07473692,-0.06119674,-0.056784015,0.04759661,0.049163558,-0.06356074,-0.017376427,0.012320349,-0.059474852,-1.836974e-33,0.07772751,-0.036555104,-0.015124425,-0.15241249,-0.13240725,0.15052083,0.040231682,-0.052952792,-0.080250986,0.018399008,0.119856425,-0.027807988,-0.0009862273,-0.024406394,0.0014564343,0.0122894645,0.019892113,0.01564875,-0.01995856,0.068087704,0.072383575,0.025202809,0.014485709,0.05273572,0.0405041,-0.0042707217,0.0037449987,-0.05558694,0.0028230655,0.025721129,-0.057662293,0.013501668,-0.014936319,-0.0035973475,0.052818224,0.043123033,-0.026281312,0.032668866,-0.0437688,-0.017122252,0.016830334,0.023905214,-0.02049101,0.061318915,0.034803044,0.019466216,-0.12838966,-0.038062237,-0.030385487,-0.05652324,-0.0052950038,0.043312345,0.03616582,0.030551478,-0.0054391143,0.03692962,0.093332395,-0.08824802,0.076465845,-0.008520797,-0.078902885,-0.027539475,0.00377116,0.035168793,0.05423132,0.04478743,0.008281705,0.034624454,0.006163351,-0.046572126,0.032386426,-0.01692863,0.09126431,0.02178918,-0.07372079,-0.0030528232,0.064312875,-0.040661618,0.03332626,-0.024203803,0.08627143,-0.034406357,-0.03427283,-0.06408115,-0.030219302,-0.115649514,0.016001135,0.06871463,-0.018190827,-0.050329916,0.019900693,0.053264376,-0.052709103,0.00013066386,0.13388926,-2.7450588e-08,-0.007891823,-0.041084964,0.08312739,-0.0036413244,0.07038598,0.115836695,-0.02013161,-0.011819854,-0.03013197,0.009361592,0.052461654,0.051035903,0.009704106,-0.011988722,-0.016262757,-0.035961527,-0.018595727,-0.0038430113,0.02322606,-0.029736826,-0.11879784,-0.005392899,-0.009099707,-0.06867067,0.036341902,-0.12190098,-0.0097302655,0.06254974,0.0011750602,0.012442734,-0.06875401,0.03294274,-0.039586954,0.012986047,-0.018159764,0.03030229,-0.0029841,-0.053846046,-0.111288145,-0.0070494073,-0.0750651,0.041974094,-0.0018262736,-0.070273116,0.005112729,0.049751494,0.020679245,0.0005530118,-0.021469386,0.034928504,0.005933798,-0.001162584,0.0013365978,-0.048807237,-0.10967291,0.01523407,0.046671927,-0.066676065,-0.0807136,-0.046689034,-0.013697209,0.026100015,0.07188395,0.03203686 +1.17.2.1,"This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases, but differs from most other members of this family. While most members contain an FAD cofactor, the large subunit of this enzyme contains three c-type cytochromes, enabling it to interact with the electron transfer chain, probably by delivering the electrons to a cytochrome oxidase. The small subunit contains a typical molybdopterin cytosine dinucleotide(MCD) cofactor and two [2Fe-2S] clusters [1].",384,1.0,-0.04989738,-0.09648575,-0.10653721,-0.045292396,0.10369923,-0.0066077765,-0.080056295,0.065333866,-0.042694405,-0.067523584,0.09398894,-0.08730838,-0.053668514,0.020712165,-0.05338517,0.043240078,-0.05015536,-0.066803694,0.061655562,0.0015889544,0.01854032,0.05067157,0.012635434,-0.02463296,0.005049312,0.11652773,0.047934912,-0.052081272,-0.020247567,0.015173738,-0.022983257,-0.01570404,0.039229605,-0.0140959425,0.048688777,0.0954236,0.05949656,0.007836925,0.07044827,0.0005586233,0.035378207,0.0519745,0.03237408,-0.037422076,0.011097986,-0.030363575,-0.030562298,0.020602988,0.040130243,0.0029841182,0.007427764,-0.058038097,0.009093893,0.065170325,0.04090174,0.061946273,-0.031006247,-0.048713036,-0.011933053,0.03750218,0.039722618,0.027719228,0.055382654,0.039492857,0.10790656,-0.055217948,-0.014821595,-0.06551516,0.028275393,-0.086100705,-0.041317914,-0.0124716945,0.0077455034,-0.0144076925,-0.03490552,-0.010261119,-0.0268165,-0.06737533,0.062905975,-0.07507421,-0.017898116,0.012493955,0.09876968,0.08428606,0.018047534,-0.09366791,0.032255363,0.0070477426,-0.03386042,0.06394874,0.009842755,0.042803533,-0.0085306475,-0.053827763,-0.048488047,0.021252615,0.08328629,0.08538834,-0.0042013857,-0.045641225,0.013078778,0.088571526,0.037047267,-0.068502404,-0.051911682,-0.054745775,-0.004390459,0.086120546,0.038034823,-0.0019642692,-0.028061952,0.02713554,-0.004611192,-0.03485535,-0.015941776,0.04302104,0.060762327,-0.00017861825,-0.020024285,-0.0068204426,0.039875235,-0.09304019,-0.009036143,0.070824236,0.026961597,-0.020075021,-0.1620296,3.059573e-33,0.048188988,0.045230195,-0.019522203,-0.03947229,-0.0032032416,-0.00051889184,-0.062000204,0.0297369,-0.032003514,-0.010853452,-0.03869775,-0.036126785,0.04060363,0.025587574,-0.028464785,-0.07186188,-0.10788785,-0.019516576,0.088335514,-0.036155313,0.068118416,0.095111966,-0.031080665,0.007291017,0.047451794,0.027525121,-0.011747933,0.042864636,-0.008454797,0.009569306,0.012402998,-0.060283665,-0.12091533,-0.0016589811,-0.00058148376,-0.039093003,-0.02732927,-0.12903681,-0.021651685,0.032432146,-0.024557116,-0.030136403,0.037436478,-0.08265665,0.050802168,-0.064422764,-0.09081923,0.0005273524,0.007466076,0.05670208,0.029690892,-0.08598701,0.03439698,0.03213124,-0.024866661,-0.04184094,-0.062339198,0.010997416,0.033341993,0.06251876,0.04238389,0.02045361,-0.038220853,0.0849999,0.015976818,-0.023299707,-0.038607836,-0.06126825,0.020904886,0.11474649,-0.079270735,-0.031669423,0.057324156,-0.046310812,-0.010541186,-0.07597543,-0.027368685,0.012511089,0.00591487,0.010159292,0.009534279,-0.05937242,0.021211045,-0.06421715,-0.024108402,0.034907516,-0.06763954,-0.059601944,-0.045438655,0.034043666,0.024562625,-0.07686569,-0.03603867,0.012720549,0.007143427,-4.386811e-33,0.06392094,-0.037399635,0.12445304,-0.08756855,-0.08996939,0.07121888,0.042843815,0.009959208,0.03780932,-0.023987107,0.05028682,0.050477076,0.014418779,-0.07270312,0.027416926,0.08366258,0.03511161,0.040529538,0.026296185,-0.028923443,0.05157618,0.03678902,0.023172254,0.050231684,0.06113006,0.043360453,-0.0283537,0.006602324,0.060506336,0.05482503,-0.06377373,0.061084002,-0.017482975,0.010448064,-0.0037484344,-0.017923808,-0.064366065,0.029746505,0.012785153,-0.0022028675,0.0024502815,0.05165334,-0.004431806,0.12603588,0.00067540165,0.073376216,-0.035968956,-0.03250161,0.0385644,-0.019846555,-0.041221764,-0.034387812,-0.04483108,0.033126384,0.011983768,0.07021141,0.003573366,0.061811622,0.0066924267,0.010824923,-0.017182063,-0.09426647,0.019064398,-0.039188202,0.055298142,-0.0066057183,0.00084347394,0.09376037,0.011071162,0.038098454,0.031238917,0.005007437,-0.007842158,0.023457501,-0.097325556,-0.00579627,-0.005440965,0.005335717,0.020963306,0.017637646,0.07652827,0.03257265,0.028804673,-0.025227606,0.028560167,-0.061093748,0.052341416,0.14383464,-0.014434772,-0.02918646,-0.012343259,0.046187323,0.053980827,-0.029718192,0.057360493,-4.152084e-08,0.0066284128,-0.111338705,0.065145575,-0.06670214,0.053361814,0.06673365,-0.049333338,-0.01330917,-0.015206235,-0.025081608,0.02645102,0.04235671,-0.046602927,-0.046382364,0.044533093,-0.0015804488,-0.073368356,0.006834974,-0.021694213,-0.0060316278,-0.07573004,-0.079152346,-0.123414956,0.07565737,-0.074774,-0.046671752,0.081645064,0.043298203,0.0019374677,0.0032423052,-0.08798981,-0.004522242,-0.0043038256,0.012098463,-0.07962411,-0.0014435615,-0.051802613,-0.07249574,-0.067870736,-0.054907892,0.008751674,-0.063423686,-0.04643978,0.023057431,0.028189251,0.03292082,0.0069984864,-0.00049147126,-0.028481795,0.00064108445,0.055905983,-0.044429436,0.036531027,-0.034260582,-0.10193122,0.025168698,-0.062097494,-0.06445551,-0.016276889,-0.040644377,0.019918786,0.014825112,0.14679973,-0.015461826 +2.1.1.166,The enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA [3].,384,1.0,-0.026724406,-0.030838026,-0.115698874,-0.02298878,0.05244968,0.00392511,-0.095052525,-0.10168712,0.0040392755,-0.006172182,-0.010340127,-0.03012543,-0.04587123,-0.025830757,0.020798132,0.07526064,-0.16163395,-0.011922666,-0.020569403,-0.0116591435,0.04943965,0.055237316,0.031465437,0.012569675,0.01614264,0.08312102,0.06671431,-0.017744988,0.044336375,-0.062189102,0.031595495,-0.033433847,0.03611825,-0.10429076,0.01875841,0.018568708,-0.062174905,-0.058123693,0.006376121,0.03489997,0.019608457,0.02683641,-0.005430493,-0.0073757684,-0.0074113393,-0.010621956,0.0036914588,-0.008566102,-0.0012163,0.047009256,-0.040268313,-0.09048242,-0.029191477,0.0145179005,0.08791849,0.030476708,0.017278273,-0.0022247224,-0.053346783,-0.0613406,0.09086051,-0.05242289,-0.014934559,-0.027221778,0.019565819,-0.03935122,0.005012713,-0.060087837,0.02017155,-0.018865915,-0.076653615,-0.010008735,-0.01043644,0.021274596,0.043262277,0.02928772,0.09411329,-0.045277644,0.014073605,-0.050996527,-0.006688297,-0.018546002,0.019119607,0.019903382,0.004851235,0.008391939,0.022237169,0.0738961,0.09454858,-0.0014665829,-0.031383034,0.008862448,0.0004997935,-0.030595576,-0.05778861,0.041646298,0.07987768,0.059040572,-0.00052402774,0.02131095,0.04662295,0.07959195,-0.106031336,-0.047691148,-0.042158034,0.025716983,0.0152401365,0.052327644,-0.022209281,0.013476147,0.11131079,0.025956653,0.05594168,-0.009166655,-0.019404287,0.07522184,-0.026408687,-0.026151212,-0.00528056,0.01422903,-0.03458107,0.024695877,-0.0017679189,0.02012288,-0.065848544,-0.03151925,-0.15237173,-3.0767804e-33,0.009231281,0.03857636,-0.021255016,-0.011339296,0.022697164,0.012575737,-0.063497655,-0.036228463,-0.016311755,-0.047920477,-0.057185613,-0.108835764,0.083767936,-0.031509552,-0.020461632,-0.018843086,0.016333537,-0.006827239,-0.016687274,-0.024262289,0.035877883,0.0840157,-0.06861384,-0.023264283,0.013203368,-0.0019293338,0.055644996,-0.026019178,0.08529163,-0.009504968,-0.012979916,-0.08512496,-0.13662703,0.044044837,0.088057674,-0.041054554,-0.03167578,0.017178977,-0.009801249,0.123386696,0.06005732,0.052346528,-0.017848335,0.0058294274,0.026556738,-0.039521385,0.02595787,0.13015144,-0.0031386411,0.036419477,0.0074268333,-0.003266791,0.019253295,0.0023673577,-0.10401377,-0.05948539,-0.03612669,0.0037482344,0.016557416,0.019301329,0.015481897,-0.020128792,0.05162101,0.06575563,-0.044712264,0.03304542,-0.027373534,-0.035757642,0.04439524,0.095752865,-0.05750023,0.00367697,0.13138364,-0.030367306,0.020158578,-0.05231778,-0.028645124,-0.03175394,0.08746736,0.03562385,-0.008871659,-0.023122678,-0.036185216,-0.03267514,-0.07928627,-0.0118518295,0.005091326,-0.060857587,-0.020566216,0.13865356,0.030434318,-0.0739565,0.008373941,-0.0038160665,0.044381637,1.011066e-33,0.08160029,-0.07253914,0.08817826,-0.08788452,-0.058763087,-0.006181121,-0.003693626,-0.03901064,-0.085192226,-0.11529015,0.13378744,0.06648374,0.02926673,0.016552433,0.081607066,-0.034343038,-0.004225852,0.108667225,0.019518934,-0.022813562,0.06330795,0.031023223,-0.08592508,0.06112829,0.0024148587,0.04714075,-0.008535385,0.0071311183,0.13867651,0.03267481,-0.04042386,0.017459426,-0.026228754,-0.001896761,-0.008010568,0.11407036,0.022191659,-0.039385106,-0.027123064,0.06952273,-0.065713614,0.0001695253,-0.022165714,0.09999187,-0.01041116,0.04748363,-0.057917558,0.03405016,-0.03296843,-0.05624299,0.05055676,-0.060277563,-0.07583582,-0.0056835003,0.04965323,0.043929517,-0.023495106,0.022138597,0.035463486,-0.050901663,-0.0029658875,-0.015018426,-0.00023690826,0.040146366,0.0069185356,0.053169005,-0.0015796324,0.02294157,0.052035924,0.032360215,-0.051350717,-0.007713131,-0.018515728,-0.019842636,-0.011844856,-0.02535799,-0.027860746,-0.03717007,-0.029109785,-0.05736883,-0.020636257,-0.017310139,0.061029434,-0.013259667,-0.031948168,-0.090820245,0.07197359,0.0868138,-0.06514813,0.027485823,-0.021245452,-0.022483125,-0.046986435,0.09129864,0.053818107,-2.7031161e-08,0.0070077684,-0.083831325,-0.005069527,0.05914446,-0.036222234,0.11506546,-0.03375285,0.03194383,0.051281102,0.045134634,0.029233763,-0.033740245,0.021639353,0.030262599,0.029793141,-0.011962108,-0.043650046,0.0397885,-0.019259049,-0.060676787,-0.108965345,0.035359062,-0.08690536,-0.01207969,-0.016403215,0.030258095,-0.029794732,0.088546775,0.008715372,-0.102041736,0.039061885,-0.033445872,0.026051171,-0.0033555853,-0.05089122,-0.004272468,0.03102957,-0.03559209,0.028191667,0.007362994,0.056067932,-0.01185789,-0.073431954,0.06434766,-0.040162377,-0.03706959,-0.023985744,0.07102958,-0.06236782,-0.006539303,0.03900771,-0.025655925,0.029801564,-0.035002638,-0.03837649,-0.009815898,-0.087464854,-0.026336055,-0.040291462,0.026081715,0.0483356,-0.004454589,0.10005021,-0.098450445 +2.1.2.13,The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305 [UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)].,384,1.0,-0.037998915,-0.02581658,-0.0052546086,-0.036033984,-0.0042519774,0.016054632,-0.048008095,0.04418014,0.026330614,-0.008645188,0.018936934,-0.078002885,-0.08728016,-0.013873237,-0.028482966,0.035541277,-0.01736528,-0.02910171,-0.030255226,-0.06065089,0.020477872,0.019851778,-0.04153238,-0.016583052,0.027254714,0.05884457,0.08390129,-0.012540879,-0.030973803,-0.13032454,0.0629261,-0.054110203,0.08965896,-0.0009983599,-0.010278666,0.14533252,-0.08647278,-0.13809477,0.026140125,0.018211022,0.06728769,-0.028044766,-0.021167517,-0.07019138,0.032072246,-0.038699675,-0.0033331553,0.02957378,0.0062165093,-0.0016078089,0.097105935,0.006070499,0.002200193,-0.009102175,0.007882515,-0.024088508,-0.07951471,0.030127043,-0.04836595,0.02255237,0.03762396,0.024515746,0.032215517,0.0022503156,0.042220555,-0.055228647,0.069818325,-0.14047208,0.0096301455,-0.012860421,-0.060228705,-0.06621572,-0.022115363,-0.024827491,-0.024865065,0.0018059419,-0.042073045,-0.074883826,0.101057574,-0.06150716,0.05128666,-0.018487262,-0.02515039,0.002600219,0.011119186,0.0466184,0.030262599,-0.028905714,-0.012348053,0.02117072,0.010560672,-0.06578259,-0.03677946,-0.005529281,-0.05522477,0.029310523,-0.012376823,0.089219905,0.055026032,-0.048260633,-0.02731113,0.12553482,-0.046700124,-0.06302216,-0.047166467,-0.0039169346,0.0220867,0.06592483,-0.014156109,-0.00856383,-0.060779788,-0.102710225,0.0385765,0.044257343,-0.000545751,0.09583021,0.03865831,-0.07221004,0.007889113,0.00986948,0.0541899,-0.0662788,0.030870343,0.08299969,-0.058113806,0.03824841,-0.09103099,1.0314582e-33,0.051534057,-0.05842963,-0.00028282034,-0.046695646,0.025362622,-0.008087501,-0.07357543,0.045242745,-0.05574991,-0.030529981,-0.06515549,0.067762464,0.13223688,0.08108285,-0.08040147,-0.050238457,0.007557454,-0.02295148,0.047234714,-0.031040683,0.0041508065,0.028642463,-0.059977636,0.072193384,-0.014263274,0.022576777,-0.054893527,0.024297826,0.034561798,-0.008481974,-0.05696366,-0.06846703,-0.13682716,0.00086266134,0.00022459839,-0.010455426,-0.0089942,-0.009808852,-0.009324793,0.01982323,-0.023699963,-0.007915652,0.0021672084,-0.10027559,0.013491288,0.028671222,-0.025165413,0.086150706,0.06697071,0.015299961,0.06351846,-0.038667165,0.090143785,-0.11960756,0.035133775,0.05003155,-0.045116454,0.01732334,0.050443135,0.11566782,0.005234804,0.094349675,-0.06795439,0.011789833,0.0028255505,0.01801809,-0.06373438,-0.03813208,0.044047017,-0.017405791,-0.07326706,0.033647876,0.10746944,-0.034034424,0.018030684,0.028422834,-0.07274417,0.013991756,-0.03134343,0.06689631,-0.059081182,0.0071131955,0.036847718,-0.02310115,-0.0022668329,0.020067321,-0.03916041,-0.0056035193,0.00864413,0.085133746,-0.038746584,-0.0099117765,-0.06173932,0.016805906,0.074102454,-3.743519e-33,0.074089155,-0.057810597,-0.05237025,-0.014999961,-0.013862058,0.09488475,0.034407664,-0.026002677,0.079834364,0.051692355,0.063488506,-0.02161834,0.039125383,-0.05597014,0.056095984,-0.01133156,-0.11023037,0.10236378,-0.03668686,0.06136357,-0.04210625,0.090645835,-0.0023354667,0.050700862,0.07578784,0.0028858616,0.015826093,0.018244207,0.054112412,0.01270254,-0.053463798,0.0062600817,-0.06280069,0.009492911,0.0060518044,0.032433387,0.019039914,0.008086277,0.050269682,-0.056783963,0.013531247,0.03596406,-0.0064194594,0.062163472,0.09291805,0.05534907,-0.044391572,0.036701873,-0.080892965,-0.039604347,0.003610853,0.03312195,-0.05778322,0.017598355,0.028961914,0.11226832,0.056719407,-0.013382245,0.03629775,0.013384685,-0.05959525,-0.07754396,0.081564434,-0.033855747,-0.007318889,-0.011842861,-0.03361907,0.028374517,0.024231477,-0.01050144,0.10651658,-0.0059756506,0.007015046,0.008823861,-0.015112027,-0.038758308,-0.09013469,-0.06836774,0.028468734,-0.033435114,0.007129178,-0.017443292,-0.0210467,-0.05589175,0.014437157,-0.03380546,0.022439612,0.10329969,-0.027542397,0.01113704,-0.034792375,-0.04849454,-0.07481391,0.075235285,-0.01080324,-3.6425593e-08,0.046951186,0.013028729,0.053418495,-0.033564094,0.063812785,0.047296576,0.05001872,0.011301558,0.0069438857,-0.02598406,0.019686561,0.04419688,-0.011142298,0.006214618,0.046045262,0.005729172,-0.03142576,0.033194233,0.012990897,-0.012205711,0.004228055,-0.08114845,-0.08761877,0.011691333,-0.0052171056,-0.10699205,0.057505894,0.06399598,0.028496068,-0.061321642,-0.04185082,0.04669747,0.042879704,-0.01930928,-0.008510204,-0.027127411,-0.018617759,0.021861555,-0.055487677,0.08488875,-0.019035606,-0.100226514,-0.026350865,-0.017193375,-0.0057092872,0.07650701,0.024162738,-0.016492471,-0.036182612,-0.0039282944,-0.01675308,-0.037824206,-0.013786867,0.009813763,-0.03261441,0.022082238,-0.04683272,-0.14353748,0.015154682,-0.037789103,-0.005455387,0.08244929,0.12084084,-0.033906583 +2.3.1.191,"The enzyme catalyses a step of lipid A biosynthesis. LpxD from Escherichia coli prefers (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] [3], but it does not have an absolute specificity for 14-carbon hydroxy fatty acids, as it can transfer other fatty acids, including odd-chain fatty acids, if they are available to the organism [5].",384,1.0,-0.08407003,-0.065621935,-0.07369753,-0.032162815,0.003690101,0.07068733,-0.08686685,0.020880772,0.035147388,-0.037677184,0.0058332686,-0.060773842,-0.10219771,-0.00046315347,0.06611333,-0.026169341,-0.05768929,0.04887788,-0.0029088086,-0.039263155,0.08281627,0.011492887,0.013306125,0.0060872617,-0.020890083,0.0025935615,0.077151634,-0.07858064,0.026231244,-0.014338496,0.04803414,-0.045934808,0.018453704,-0.059849095,0.08952412,0.0330224,0.039082613,-0.06319041,0.08841525,0.03882804,0.037687168,-0.055999413,0.0009320827,-0.027355595,-0.023300968,-0.082200415,-0.054992277,0.049554616,0.026251934,-0.050402135,-0.047883056,-0.06592138,-0.012382285,-0.004629097,-0.01773108,-0.0116429785,0.008888053,-0.024970219,0.0076538934,-0.002901082,0.014421094,-0.00041391872,0.06625257,0.057530098,-0.03225608,-0.09675196,-0.051715873,-0.08911693,0.0072095627,-0.030294407,-0.07195596,-0.06318121,-0.06618067,0.0155911455,0.02325601,0.014558994,-0.010981872,-0.09866458,0.0055665933,-0.04822661,0.032581266,-0.00043585102,0.019540215,0.115754545,0.027655838,-0.060300525,0.025800355,0.030115964,0.0048990697,0.090678275,-0.011458357,-0.0043337727,0.034784358,0.02534098,-0.0799212,0.04981402,0.058212496,-0.022026166,0.04201587,-0.050397698,-0.027392771,0.06195845,-0.024150131,-0.034415547,-0.07051322,0.00474398,-0.0042090327,0.061494384,-0.045440562,-0.0841922,-0.01651543,0.030297749,0.05115491,0.010373305,-0.047637146,0.046395585,0.026360398,-0.122816734,-0.005442734,-0.047813855,-0.06394371,-0.14556201,0.042895507,0.06972479,-0.029443273,0.062262736,-0.061699845,1.2199917e-33,-0.008441194,-0.042247795,-0.053271145,-0.04301531,0.014701559,-0.032899786,-0.057012293,-0.050999064,-0.07930117,0.019666357,-0.034637604,-0.1066039,0.01596576,0.08691575,0.03067639,-0.010008075,-0.03165848,0.08232496,0.091767214,-0.009930738,0.0039001082,0.050969,0.064695515,-0.019347275,0.06917883,0.058388896,-0.031785667,-0.0065198266,0.05223861,-0.014305577,-0.02267144,-0.054592766,-0.035419755,0.0409053,0.034862578,0.028753104,-0.005671127,-0.05386105,-0.037686348,0.035090193,0.011455241,0.029629,-0.0018959349,-0.0669844,-0.0026370147,0.054595694,-0.05738101,-0.0076692086,0.03634623,0.019307723,0.08930239,0.06499451,0.06665976,-0.007711956,0.025121491,-0.038200893,-0.053067822,0.08564858,0.03648399,0.045344997,0.0020610264,0.08404824,-0.035727814,0.0064877844,0.027372958,0.017418899,-0.000958211,-0.04726576,-0.02307013,0.090430036,-0.00018571259,0.02062959,0.062395517,-0.010866481,0.111081734,-0.0155588975,-0.014035068,0.0061348784,0.05644245,0.0056824097,0.028323997,0.043577056,-0.010092405,-0.03043348,-0.041593242,-0.017020077,-0.09728594,-0.034456383,-0.0031367133,0.053513803,-0.007285312,-0.07702147,-0.0320023,0.112196885,-0.040584963,-3.1722967e-33,0.008213962,-0.09328656,0.04602264,-0.13855812,-0.07347545,0.034865316,0.03912222,-0.0112310015,0.13050708,-0.001398048,0.06900461,0.00029704106,-0.008592821,0.011532053,0.029227074,0.042444732,-0.038556647,-0.03754205,-0.048637778,-0.044896364,0.026152762,0.02901162,-0.05156749,0.15528066,0.01874823,0.07234742,-0.047024295,0.095515005,0.019132378,0.005721633,0.032277916,0.006027253,-0.018114207,-0.011410895,-0.0812235,0.0687398,-0.068756305,0.07160353,0.036993504,0.05458948,-0.030264972,-0.010959632,0.03276975,0.008580391,0.0033360498,-0.013165397,-0.042050906,-0.042584326,0.01717043,-0.040835116,-0.005001138,0.009302633,0.0900617,0.03976132,0.04872572,0.061112966,0.026284572,0.05273847,0.0540424,-0.11740125,-0.049255416,-0.009878854,0.0419847,0.019931568,0.025210915,0.063721575,-0.043341868,-0.08891273,-0.005245135,0.0035773888,0.06518869,0.065147705,-0.04698594,0.09215455,0.030602505,-0.03144425,-0.027153786,-0.08166342,-0.044754554,0.048343256,0.027425513,0.021561483,0.020932151,-0.075303674,-0.017735118,-0.025438217,0.020770088,0.011698085,0.018019151,0.04807521,0.0070800413,-0.0045020483,-0.035242006,-0.0001628817,0.083576046,-3.9370526e-08,-0.034797892,-0.054353446,0.050314233,-0.05911209,-0.048325427,0.00055501255,0.0071033104,0.0055784495,0.06156654,-0.063930914,0.010798813,0.09009131,0.059893616,0.046133332,0.021865318,-0.04724205,-0.068502456,-0.05415561,0.008909802,-0.06755638,-0.06641918,0.029235652,-0.037773103,0.01275158,0.0063988,-0.0913413,0.020553537,0.00012642486,-0.013434858,0.010607921,0.0102989655,0.03989307,-0.0016622932,0.03218429,0.047096565,0.020546615,-0.023135453,-0.06888342,-0.021246353,0.048829474,0.02685132,-0.008677908,-0.09207585,-0.016102089,0.002208444,0.034872267,-0.09325803,0.016967738,-0.0006257515,0.030988242,0.07080576,-0.038649585,-0.039369546,-0.022030862,-0.04679836,-0.047912195,-0.09767709,-0.019344768,-0.01011906,-0.036707934,0.04860164,0.013741055,0.2397749,-0.011418825 +2.3.1.304,"This is the key enzyme in the biosynthesis of polyhydroxyalkanoates (PHA), linear polyesters produced by bacteria as a means of carbon and energy storage [6]. The enzyme catalyses the stereoselective, covalent linkage of (3R)-3-hydroxyacyl-CoA thioesters in a transesterification reaction with concomitant release of coenzyme A. The growing polymer is attached to a conserved active site L-cysteine residue. Three types of PHA synthases have been proposed based on their substrate specificity and enzyme structure. Type I and type III synthases preferentially polymerize short chain hydroxyalkanoate monomers containing 3-5 carbon atoms [1,2]. The difference between these two types is that type I synthases are composed of only a single subunit (PhaC), whereas type III synthases are composed of two different subunits, PhaC and PhaE [3,5]. Type II synthases are also composed of a single subunit (PhaC), but preferentially polymerize monomers containing more than 5 carbon atoms [4].",384,1.0,-0.07397373,-0.082539216,-0.05495859,-0.040736362,0.066278644,0.055537447,-0.102222435,0.01895865,0.012784147,0.010093143,-0.032722916,-0.07913698,-0.07799562,0.030572657,-0.00754537,0.015115249,-0.08449205,0.009223612,0.0033828851,-0.0044750622,0.11554078,-0.012956707,-0.022121662,0.08288246,0.0033312244,-0.06908776,0.07388197,-0.07087176,-0.017602755,-0.027276546,-0.05850519,-0.013195985,0.0071067633,-0.04205639,0.07470593,0.11711459,-0.08532873,-0.08240688,0.08505472,0.042761855,0.083605185,-0.006197673,0.0083157355,-0.056974586,-0.014045106,-0.042889718,-0.006171852,-0.038231343,0.005919813,-0.04977545,-0.06516641,-0.04692848,-0.051884346,0.010653557,-0.0442993,-0.008429784,0.03523577,0.050950598,0.021436797,0.076429605,-0.0010564784,0.023928873,0.014198839,-0.043727443,0.004115945,-0.02155872,0.027192289,-0.020558408,0.041754413,-0.03322476,-0.15768753,0.0006847591,-0.04159294,0.053828023,0.0013345269,-0.012603016,0.024736615,0.025722401,-0.040005267,0.0071535166,-0.024594715,-0.02630174,-0.03210435,0.05991955,0.009842658,-0.021891506,-0.02788696,0.04754977,0.06302762,0.039746348,0.027445743,0.051937267,0.017746918,-0.044680614,-0.0082709165,0.05706637,0.024236012,0.027195688,0.13451864,-0.06664651,0.075968,0.010184214,0.026633421,-0.07589855,-0.021908034,-0.013995797,-0.019120341,0.06753225,0.014411489,0.06121216,-0.057245158,0.016760493,0.052338615,-0.053451993,-0.08735769,0.12500405,-0.016749956,-0.07263633,-0.014989375,0.05228079,0.064793184,-0.054726597,0.1331958,0.044400413,-0.04469883,-0.032121018,-0.11074674,5.3418662e-33,0.06301409,0.043998808,0.04942256,-0.010079918,0.010220979,-0.019505762,-0.066110656,-0.014635286,-0.07606693,-0.05272522,-0.0037897069,-0.013434635,-0.0108326785,0.023533994,0.0060726316,-0.05458108,0.030213881,0.005185626,-0.0318831,0.02315303,-0.0032720328,0.0136724925,-0.014640455,0.061858803,0.062301885,-0.016052678,0.026477128,0.01126102,0.012889504,-0.039150033,0.0019501587,-0.13210574,-0.04990389,0.0006578196,0.0002442397,-0.05741608,-0.048659433,-0.04816128,0.024218967,0.020992462,0.06600437,0.018650986,0.058007587,-0.027343782,0.05604381,0.024909806,-0.019309968,0.076088145,-0.030904105,0.044970118,0.02659873,0.020090835,0.024002613,-0.00043877176,-0.051525544,-0.010095228,-0.037019387,-0.016601091,0.032776482,0.0004998439,-0.033586174,0.079415455,-0.016050203,0.015157679,-0.10847249,0.010781077,-0.046435695,0.035050318,0.0034255155,0.057679065,-0.03749708,-0.06381608,0.014112569,0.054091636,0.047713242,-0.061943285,-0.14252973,-0.0032014714,0.04868045,0.0156093845,0.005342114,0.05502781,0.021185657,0.008753547,-0.06925133,-0.07163541,-0.0095005855,0.002328727,0.010005475,0.06875814,0.03548718,-0.11433888,0.0480453,0.05278899,-0.023191558,-6.9433895e-33,0.05660836,-0.052045565,0.035117727,-0.10955719,-0.03231175,-0.041787915,0.03726809,-0.025639238,0.031118946,-0.068965405,0.06421846,-0.010479457,0.011246734,-0.0024264841,-0.050084308,0.026345601,-0.008224298,0.083987765,0.0093439715,-0.024817698,0.075329386,-0.050451122,0.026168952,0.05455348,0.03873027,0.022678997,-0.013917626,0.091504365,0.029157106,0.07589991,-0.037976146,-0.016347798,-0.030995578,0.04458539,-0.022262862,-0.016816657,-0.04272687,0.022649746,0.056810267,0.05596819,-0.016433297,-0.036457032,0.037308786,-0.0012421274,-0.012299986,0.074228786,-0.053156994,-0.04968753,0.04740511,-0.026395755,-0.02538553,0.037349723,-0.020360919,-0.0001801794,0.0041212705,0.018657641,0.0114540355,0.026118886,0.002097695,-0.06723253,-0.027282445,-0.09989614,0.074847326,-0.01241386,-0.022114892,0.054021023,-0.0038983943,0.027161332,0.00026120007,-0.01261673,0.093500525,0.059540786,0.02256705,0.025036603,-0.04685778,-0.06458537,-0.02988354,-0.0017260667,-0.038162157,-0.021271553,0.06004785,-0.0036215994,0.00017757916,-0.060857527,-0.04828785,-0.06056587,0.10417425,0.032602508,-0.051764593,0.029211994,0.0011111102,-0.013330932,-0.031865653,0.106914595,0.0960461,-5.03167e-08,-0.027405608,-0.09044683,-0.0070516705,-0.06487306,-0.041382734,0.031510286,-0.0055819736,-0.04402678,0.028095225,-0.065395385,-0.07056799,-0.0071608536,0.024048576,0.073985316,0.05743849,-0.04017806,-0.0662454,0.040411424,0.00092994544,0.00341922,-0.020784907,-0.003338363,-0.1204728,0.016779434,-0.009617293,-0.029652646,0.0011000654,0.038420107,-0.025137808,0.013535437,-0.03848549,0.10226282,-0.0037940643,0.036001682,-0.046439968,0.003171993,0.0035540273,-0.06831685,-0.09253726,0.047118608,0.044386413,-0.021065231,-0.11610914,-0.0024806024,0.12632915,-0.046058297,0.004923,0.051803716,0.029116377,0.039779272,0.0973796,-0.013504477,0.0167109,-0.04173152,-0.0063559883,0.034434743,-0.0428222,-0.033717442,-0.06949284,-0.043927737,0.037767958,-0.07144577,0.23197205,-0.057411194 +2.3.2.16,"The enzyme from Staphylococcus aureus catalyses the transfer of glycine from a charged tRNA to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphosphoundecaprenyl-GlcNAc (lipid II), attaching it to the N6 of the L-Lys at position 3 of the pentapeptide. This is the first step in the synthesis of the pentaglycine interpeptide bridge that is used in S. aureus for the crosslinking of different glycan strands to each other. Four additional Gly residues are subsequently attached by EC 2.3.2.17 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase) and EC 2.3.2.18 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase).",384,1.0,-0.05486859,-0.07542436,-0.09625723,-0.07834737,0.00097607216,-0.013724757,-0.059714414,0.03084395,0.021505699,0.008073274,0.0328943,0.02879248,0.00950996,0.050499074,-0.08525025,-0.01825218,-0.07699435,-0.032082703,-0.010535504,0.07126792,0.054214798,0.059926372,-0.053735927,-0.050209913,0.0041047186,0.03179785,0.0057461406,-0.03177004,0.02116248,-0.10012272,-0.035814103,-0.077366106,-0.029212272,-0.077373795,0.013910378,0.013334671,-0.04451728,0.03449452,0.09249699,0.0041546877,0.014549147,0.020026948,0.027819673,-0.05427322,0.0041966895,-0.007899622,0.012757824,0.03153648,0.011968258,0.044873293,0.049474664,-0.015634693,-0.041097827,0.0859968,-0.048693072,0.010029995,-0.15194426,0.011140721,0.025190685,0.02512531,0.014964845,0.015381072,0.051627386,-0.048426993,-0.048669882,-0.13435104,0.07009353,-0.019675486,0.0062004025,0.025059205,-0.0533815,-0.02721745,-0.006919176,-0.0023555572,0.041682005,0.06769795,-0.0250354,0.053704914,0.012182418,-0.000887213,-0.00542691,-0.040990118,-0.008863268,0.17188294,0.0063536097,0.039193377,-0.03399288,0.038299512,0.038543437,0.01877812,0.084898524,-0.047531698,0.011097566,-0.036292206,-0.0021084172,0.005187521,-0.030514326,0.032315753,-0.012137215,0.008167144,-0.04742757,0.035306476,-0.029781586,-0.0317178,0.0282509,-0.010552264,-0.0025725127,0.025004614,0.016385475,-0.06954755,0.01615518,0.053573176,0.06726944,-0.02924064,-0.0438594,0.07731947,-0.009212015,-0.047039818,0.051108103,-0.057334486,0.0072993212,0.02469763,0.04280152,0.017437868,-0.0680837,0.07180913,-0.015364385,4.27467e-33,0.01791878,0.025769576,0.05778969,-0.034759738,0.008173633,-0.029473707,-0.101908185,-0.0105008045,-0.030889787,-0.028408993,-0.074828096,-0.0011355542,0.038464576,0.0026073225,0.0009504037,0.051873762,0.053179275,0.0025252015,0.026347825,-0.06783249,0.0758268,0.020037537,0.014589714,0.025566058,0.08889683,0.07137757,0.06613552,-0.027986512,0.0827369,-0.0052548363,-0.05814703,-0.051324107,-0.044103153,-0.00983633,0.028820725,-0.01489864,-0.045808896,-0.08752855,0.119800106,0.027437245,0.07471589,-0.0015915754,0.03397981,0.012772788,0.05170667,0.06351014,-0.058347795,0.063393116,-0.030886162,0.055574425,0.05369952,-0.069143854,0.044600412,0.03142738,-0.069662385,0.006835413,-0.045196753,-0.04897613,0.020223735,0.117944404,-0.026500763,0.058065027,-0.037342902,-0.019030651,0.022796977,0.045548223,-0.06425667,0.027246457,-0.014784049,-0.018392425,-0.055104848,-0.055570293,0.089133516,0.045158442,0.009156998,-0.014071495,-0.0060423426,0.030573908,0.045046505,-0.0051364186,-0.06678389,0.05450219,-0.06627168,-0.046450656,-0.03675846,-0.016663752,0.010086741,-0.17108917,0.013351047,0.08078671,0.010056436,-0.010064915,-0.04830413,0.049189694,-0.08195985,-5.3809018e-33,0.08251008,-0.15590973,0.06293074,-0.03603229,-0.04877252,0.023340672,0.036756057,-0.06331571,0.07823245,-0.038538463,-0.00067875825,0.0674145,-0.0038901032,-0.0075521455,0.019525468,0.00026320608,0.03411143,0.04953364,-0.012447569,-0.077128984,-0.011517745,0.03785711,0.024649734,0.032786604,0.044918515,0.0076940497,0.06791903,0.050198313,0.03131508,0.09843678,0.006422888,-0.027921041,-0.045247372,0.030009782,-0.066694066,0.08512725,0.03817863,-0.019222306,0.027513333,-0.0708392,0.054775737,-0.0025844818,-0.033291068,0.0056440826,0.05822496,0.082192525,-0.10891668,0.051704023,-0.047889058,-0.05391976,0.045143966,-0.0049002,0.0022536376,0.04868811,-0.002709143,0.02704759,0.057847217,-0.010957103,-0.0077883797,-0.013057963,0.013870276,-0.05270918,-0.038113676,-0.06956689,0.041290183,0.008945671,0.037816014,-0.0061702128,0.044114683,-0.02794955,-0.044899493,-0.022751167,0.0377434,-0.015091048,0.036682885,0.06844723,-0.048478343,-0.0941576,0.031957317,-0.11166471,-0.025977926,-0.003951676,0.04016425,-0.030519973,0.041829158,-0.024388652,0.047389675,0.1755923,0.011436665,0.07191246,-0.048113193,0.015971374,-0.0057379254,0.07286434,0.06355488,-5.1131355e-08,0.096526965,-0.0020041822,0.013303198,-0.040785916,-0.020216426,0.06873568,-0.065882534,0.008966313,0.010112327,-0.028469397,-0.051223468,0.04015169,0.010746589,-0.05692589,-0.08293573,0.0820426,-0.07291959,-0.03611143,-0.014348675,-0.023202341,-0.11465515,0.033394195,-0.10015407,-0.00046064935,-0.018161982,-0.081888124,0.02154794,0.013493167,-0.06158385,-0.035829436,0.025061963,-0.015872803,-0.04468955,-0.012855284,-0.032780077,-0.03969718,-0.0068582217,-0.06689981,0.06263946,0.04928498,0.04414284,0.033357043,-0.08996272,-0.01523888,0.0047418894,-0.0060014394,-0.020126894,0.02495397,-0.08436708,0.045117196,0.020069277,0.058806643,0.0365881,-0.040849347,-0.12687014,-0.050680067,-0.09111557,-0.060850624,-0.013765845,0.012847511,-0.018541267,0.0035820538,0.13219011,0.042075958 +2.3.2.17,"This enzyme catalyses the successive transfer of two Gly moieties from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc, attaching them to a Gly residue previously attached by EC 2.3.2.16 (lipid II:glycine glycyltransferase) to the N6 of the L-Lys at position 3 of the pentapeptide. This is the second step in the synthesis of the pentaglycine interpeptide bridge that is used by Staphylococcus aureus for the crosslinking of different glycan strands to each other. The next step is catalysed by EC 2.3.2.18 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase). This enzyme is essential for methicillin resistance [1].",384,1.0,-0.08830604,-0.07027753,-0.07026777,-0.074579045,0.011335039,-0.02924295,-0.05204949,0.021791333,0.045270294,0.031768285,0.027490687,0.020891488,-0.022118224,0.028206594,-0.07255971,0.026265534,-0.09197146,-0.038721222,-0.042702653,0.063945174,0.072757006,0.060167816,-0.031754058,-0.07145029,0.003525926,0.026262721,0.025442773,-0.047232956,0.054679904,-0.09441035,-0.016962571,-0.08372295,-0.04510099,-0.09659259,0.005894516,0.04889011,-0.06808699,0.014031377,0.1009597,0.03430276,0.027174387,-4.499852e-05,-0.006834127,-0.09187149,-0.025367087,-0.037216526,0.034324173,0.06905232,0.011063919,0.045083612,0.05112808,-0.04120017,-0.059008256,0.05158335,-0.03155328,0.008966891,-0.1645075,-0.0040699025,0.02921151,0.028708799,0.019325316,0.042911083,0.058834374,-0.035452656,-0.051062327,-0.13560985,0.07968358,-0.020229459,0.02481215,0.004122091,-0.0675343,-0.012698742,-0.034996893,-0.006840406,0.029837858,0.067476705,-0.0040149204,0.029472865,0.021144249,-0.013034396,0.020158174,-0.05809956,0.016938845,0.12680702,0.0010065627,0.023919567,-0.045193102,0.060315643,0.066293724,-0.0009460266,0.08828109,-0.023144215,0.019780211,-0.0068237255,-0.017533382,0.026867013,-0.00868563,0.060627908,-0.01760973,0.0308674,-0.03038511,0.054200977,-0.042409223,-0.07843164,-0.016994955,-0.00021800664,0.0057691815,0.011721671,0.0072982954,-0.078512065,0.0068624616,0.049235333,0.08111266,-0.023212267,-0.0527967,0.07421117,-0.02660804,-0.031071298,0.0644892,-0.029945938,0.020424828,0.011807642,0.04177782,0.03571107,-0.063659005,0.1077276,-0.021726722,4.2068195e-33,0.030036481,0.039645698,0.06433204,-0.0026425363,0.0025799482,-0.02465625,-0.1067246,-0.009998732,-0.08079243,-0.033400707,-0.080448724,-0.02930316,0.046452075,0.00977351,-0.0025928859,0.054077696,0.052780822,-0.003264285,0.03052545,-0.029281586,0.05839162,0.046786524,0.018693736,0.020016845,0.09064077,0.092214346,0.048058983,-0.0053399727,0.09087231,-0.0014509942,-0.034024935,-0.060613986,-0.0569443,0.00073139713,0.04316728,0.00013877686,-0.058462027,-0.07102131,0.06451,0.03121687,0.042119686,-0.020316157,-0.014653469,-0.0133250095,0.03821979,0.069322675,-0.027862687,0.036105856,-0.013535777,0.04592639,0.067134604,-0.05753429,0.03775095,0.007710648,-0.07973693,-0.023757175,-0.050704744,-0.057253115,0.04766064,0.1177027,-0.0031547635,0.06196966,-0.028175784,-0.00084892433,-0.0012017395,0.018556448,-0.1140396,0.011487686,-0.010363804,0.0011317128,-0.057679705,-0.05704137,0.08193485,0.03900753,0.0408793,-0.053135194,-0.01782662,0.006604926,0.036655873,0.0020088134,-0.039649658,0.04711919,-0.03640499,-0.065181896,-0.032323286,-0.0110412305,-0.016768036,-0.13158095,0.009888176,0.08700458,-0.01350153,-0.00424502,-0.06069575,0.008573618,-0.05469088,-5.382735e-33,0.072819315,-0.14825433,0.04298277,-0.025372317,-0.05644525,0.032363445,0.0691168,-0.072009176,0.07824714,-0.041082934,0.010932491,0.060426068,-0.0018083908,-0.0063322894,0.046822116,-0.010380076,0.028009232,0.025347278,-0.032984182,-0.062711,0.030219385,0.024269573,0.013787417,0.026086785,0.026280634,-0.0086110765,0.061103266,0.027779924,0.03403413,0.08388696,-0.027771687,-0.008805278,-0.041030217,0.042459477,-0.07980291,0.05723778,0.027947035,-0.022913387,0.017000997,-0.042473882,0.011474779,-0.0066938745,0.0028408899,0.030815916,0.042505283,0.08382426,-0.10584606,0.007939161,-0.070019655,-0.043131355,0.047926944,0.008710183,-0.0011271231,0.06091737,0.026871279,0.03776744,0.033389606,-0.005074265,0.026837321,-0.0057084966,0.0053285095,-0.08166229,-0.028571708,-0.06967038,0.069049105,0.05051581,0.052258033,0.028788168,0.016874276,-0.039058458,-0.01031227,-0.040497206,-0.0016249407,-0.037574563,0.03568365,0.050627146,-0.043326635,-0.090443976,0.008297475,-0.10912732,-0.023008572,-0.049964655,0.052989583,-0.042368375,0.04911139,-0.056904025,0.06723385,0.17918785,0.011392201,0.07097092,-0.048226874,0.006765868,0.011643799,0.069642805,0.09408439,-5.1430106e-08,0.023819873,-0.045655895,-0.025972843,-0.034415513,-0.015278149,0.054536242,-0.057028033,0.017438924,-0.0023169753,-0.033496026,-0.013330114,0.047558434,0.02825977,-0.03271368,-0.033947032,0.11860323,-0.08506837,-0.023925943,-0.006738235,-0.01093826,-0.094810255,0.0564949,-0.1254897,0.028594567,-0.022778584,-0.08376221,0.032009453,0.01847281,-0.036515035,-0.04271949,0.00075520406,-0.009396163,-0.018336454,-0.018631293,-0.040680896,-0.030453634,-0.015438408,-0.052857127,0.04001289,0.03971377,0.056235947,0.031041916,-0.0731986,-0.007448259,0.0015186644,-0.00850608,-0.046654414,0.056913342,-0.073270045,0.07614079,0.033523846,0.04612784,0.03149223,-0.021592142,-0.12266346,-0.0538496,-0.091078825,-0.044754054,-0.030581312,-0.008326715,0.0084426245,0.021456484,0.12251125,0.0022098355 +2.3.2.18,"This Staphylococcus aureus enzyme catalyses the successive transfer of two Gly moieties from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphosphoundecaprenyl-GlcNAc, attaching them to the three Gly molecules that were previously attached to the N6 of the L-Lys at position 3 of the pentapeptide by EC 2.3.2.16 (lipid II:glycine glycyltransferase) and EC 2.3.2.17 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase). This is the last step in the synthesis of the pentaglycine interpeptide bridge that is used in this organism for the crosslinking of different glycan strands to each other.",384,1.0,-0.070486024,-0.08695847,-0.10113207,-0.06884154,-0.0048585148,-0.0043033664,-0.068889655,0.0014165036,0.042407796,0.039899886,0.043567512,0.0018137714,-0.03169107,0.034912664,-0.04900468,0.01737856,-0.11312342,-0.034040887,-0.048305918,0.04497138,0.055488367,0.09580336,-0.049957477,-0.066897914,0.0066480422,0.010190936,0.005170535,-0.03642868,0.05101252,-0.10648732,-0.045268714,-0.049430694,-0.01665391,-0.08465368,0.028738296,0.052183807,-0.07525842,-0.0013925617,0.10111721,-0.0011660514,0.019463426,-0.0034660085,-0.00070452155,-0.061175894,-0.036657766,0.0199465,0.009096323,0.0791032,0.030588608,0.026117021,0.032576602,-0.019800525,-0.06487181,0.076406054,-0.06302112,0.025275487,-0.15114518,-0.0072485963,0.036049154,0.019348906,0.0038574396,0.036551785,0.06196755,-0.037726905,-0.033093322,-0.1237601,0.10688995,-0.045840748,0.012725865,0.024304414,-0.07088551,-0.025260348,-0.03198002,-0.014736001,0.03089412,0.053287257,-0.028239941,0.025840063,0.006763898,-0.010700731,0.039592523,-0.027888687,-0.0171804,0.15585437,-0.017034875,-0.0046820124,-0.055724945,0.04956329,0.051921707,0.012715052,0.05091953,-0.045732237,0.004663309,-0.015339138,-0.02147021,0.004155765,0.0068238582,0.0071108146,0.00384521,0.024486817,-0.049407292,0.0455218,-0.017225271,-0.039031085,0.030431341,0.00065541395,0.0025611469,0.03274243,-0.005783511,-0.06705278,0.018447498,0.06910236,0.07574479,-0.00783838,-0.031346615,0.07132089,-0.028066,-0.047853142,0.06033588,-0.015444377,0.032045983,0.020765072,0.044103142,0.028875053,-0.07275265,0.092731304,-0.024500096,4.346912e-33,0.02924516,0.021894999,0.0720048,-0.02614414,0.041547693,-0.024594229,-0.08243468,-0.0031673624,-0.024283983,-0.030266969,-0.086419664,-0.035765283,0.07710149,-0.0035158708,-0.023434673,0.047587857,0.016210483,0.029033363,0.03532568,-0.032759264,0.056065384,0.03674432,0.011046273,0.012806236,0.08226344,0.071326464,0.060568735,0.005383057,0.056507386,-0.008578583,-0.04913591,-0.0589383,-0.054577913,-0.008587916,0.05068734,-0.009500768,-0.032986846,-0.10121153,0.09440078,0.002526136,0.0223075,0.0035601514,-0.009686151,0.010344355,0.031204635,0.029088942,-0.07277846,0.052233107,-0.015875593,0.08778981,0.07117213,-0.06615473,0.0422966,0.0098284045,-0.0776488,-0.023154842,-0.05205253,-0.046597768,0.020504976,0.102541566,-0.025235431,0.059400663,-0.042973336,-0.006412436,0.03772895,0.047001872,-0.09300222,-0.019994289,-0.018396582,-0.02754402,-0.045684602,-0.08280042,0.08076065,0.042881414,0.0178028,-0.035010003,-0.006416663,0.023067566,0.034817655,-0.006706836,-0.055301234,0.07995448,-0.052236218,-0.07043481,-0.054270975,-0.031755704,0.021761548,-0.15878776,-0.007370383,0.072692975,0.007110456,-0.0071243034,-0.050156295,0.041586217,-0.043531675,-5.4579808e-33,0.08023135,-0.13263467,0.044151835,-0.043535914,-0.036129873,0.04092672,0.06264979,-0.0541269,0.04584521,-0.03791548,0.033704333,0.08359814,-0.02812068,-0.015957855,0.04734643,-0.021991508,0.049120508,0.03429363,-0.011553198,-0.020595925,0.02659781,0.053974643,0.02454455,0.022992667,0.043260127,-0.020097265,0.043921415,0.059707258,0.021567602,0.08044443,0.018463867,-0.015065961,-0.06962135,0.036039542,-0.048912697,0.05710908,0.036667623,0.011478542,0.015777528,-0.05275401,0.04920461,0.0025355113,0.00055409066,0.017897828,0.06272849,0.07826625,-0.07968607,0.011005615,-0.06664027,-0.041664045,0.039006554,0.014628174,-0.009013863,0.044603102,0.004507177,0.07181408,0.04872025,-0.015980955,0.0090497285,-0.034771457,0.0015725073,-0.07747557,-0.026086478,-0.04502699,0.081394814,0.020803055,0.051191885,0.017805023,0.054763086,-0.016798183,-0.05414151,-0.0006017327,0.04845083,-0.017093334,0.016773721,0.03713654,-0.059895016,-0.1143898,0.035031017,-0.12546524,-0.0186871,-0.011303593,0.038197324,-0.049428016,0.013905212,-0.059603672,0.0525555,0.16126141,0.020012865,0.085853994,-0.048758246,-0.02000208,-0.027749484,0.03996555,0.09012311,-5.0649938e-08,0.07188679,-0.017390821,-0.0008074058,-0.015329327,-0.01107034,0.042667806,-0.046320383,0.02340822,0.016261097,-0.04345001,-0.021455592,0.08005164,0.030796401,-0.04513023,-0.06556134,0.10930085,-0.08720389,-0.01919838,-0.015675068,-0.032049786,-0.09826689,0.026487488,-0.09748982,0.018964186,-0.002214488,-0.086747,0.0419826,0.023059519,-0.035367686,-0.054506846,0.012144403,-0.026346818,-0.014401039,-0.018777017,-0.028419523,-0.03583874,-0.01728396,-0.06538263,0.044903502,0.043874763,0.01205598,0.055809904,-0.09192722,-0.0033179373,0.019935388,0.0044539133,-0.046427157,0.0452055,-0.08539938,0.047751185,0.015679635,0.039673317,0.025634753,-0.028060583,-0.1283439,-0.030776424,-0.08159298,-0.033093598,-0.035810232,0.023277976,-0.022005556,0.06743734,0.13427253,0.014174883 +2.4.99.12,"The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyse the transfer of a single 3-deoxy-D-manno-oct-2-ulosonate residue from CMP-3-deoxy-D-manno-oct-2-ulosonate to lipid IVA [2-4]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [5]. ",384,1.0,-0.037582297,-0.058021076,-0.104467176,-0.105445005,0.014679695,0.06193811,-0.0625632,-0.018192863,0.05659424,0.052082587,0.03236747,-0.079004906,0.020000067,-0.0053271824,-0.036820296,0.06200586,-0.04360907,-0.0034517397,-0.026622234,0.006533311,0.1384045,0.016859718,-0.0031528969,-0.0012446879,-0.024698518,0.06943169,0.064556696,-0.06831121,-0.07346572,-0.1344339,-0.092248306,-0.041325502,0.023645513,-0.070525154,0.07474271,0.07748327,-0.046894614,0.016641023,0.12390269,-0.036270376,0.049645606,-0.02947518,-0.0071343076,-0.04749883,-0.042580508,-0.027561553,0.024252025,0.07888975,0.07400951,-0.03383743,0.030745532,-0.03498424,-0.037247248,0.0507416,-0.064661734,0.010519309,-0.017134786,-0.06969358,0.0028081331,0.06430306,-0.044130523,0.022212295,0.14555989,0.013693846,0.0027100667,-0.15519601,0.046541166,-0.031056788,-0.025388278,-0.036487598,-0.041007407,-0.01681692,-0.03553379,0.027488064,0.11293825,0.08255173,0.055332918,-0.031153498,0.017489973,-0.008206869,-0.01931857,-0.04448717,0.088659644,0.047753323,-0.0060324925,-0.03470438,0.0029328745,-0.014484394,0.03995771,0.0541981,0.029784763,-0.056890495,0.044485983,-0.009112515,-0.009985337,-0.009674251,0.012480705,0.018513545,0.11366404,-0.031207072,-0.028920406,0.009032919,0.0016189067,-0.032744247,0.06481206,-0.049671058,0.020798137,-0.0016252721,0.014451685,-0.07619362,-0.031897157,0.009980055,0.0662084,0.020540813,-0.027588036,0.049627263,0.007365896,-0.07986857,-0.008345602,-0.018317033,-0.012371597,-0.029831259,0.012379398,0.07155408,-0.028018316,0.071540356,-0.07319449,2.7019144e-33,-0.014612413,0.037097063,0.05689732,0.052817374,-0.008501646,-0.0035889999,-0.069634736,0.0029415225,-0.047185123,0.023996674,-0.13640682,-0.00042047127,0.086945325,0.046437215,-0.024655256,0.0535443,-0.00995563,-0.020180812,0.02424288,0.0064162835,0.044137426,0.012019048,-0.012158607,-0.030866815,0.09022345,0.12324971,0.029399704,0.017964942,0.059089415,-0.02032833,0.028054357,-0.04846027,-0.08098721,-0.04382044,0.020146966,0.024375532,-0.050904494,-0.006265862,-0.05597699,0.01019856,-0.05431652,-0.0010920914,-0.12511627,-0.027347181,0.029289348,-0.06492941,-0.07147074,0.032236103,0.02713802,0.061662607,0.064894624,-0.014168299,0.110459186,-0.040982798,-0.038638197,-0.0590256,-0.0064245258,-0.006146046,0.107295975,0.05213539,0.019343097,0.067745194,-0.07947266,-0.021032648,0.018684993,0.00798973,-0.014471978,0.029962467,-0.0048396173,0.0062109428,-0.04572417,-0.011517505,0.04498398,-0.023820866,0.04214569,-0.04875701,-0.08033719,-0.018825017,0.07994847,0.022087129,0.06150921,0.026968813,0.0736568,-0.038872667,-0.040939014,-0.01676548,-0.09451459,-0.021133943,-0.0020825558,0.05790001,0.023214865,0.027316408,-0.021778518,0.044008978,0.016421529,-4.80242e-33,0.070530385,-0.092055865,0.035243213,-0.098977774,-0.02593855,0.11217726,0.097186126,0.0066658263,0.0754669,-0.022261621,0.023396797,-0.0031107862,0.0406321,-0.060660426,0.042859435,0.023296576,-0.049288787,0.043104548,-0.052838862,0.0035643824,-0.035404764,0.061514173,-0.018728161,0.034892228,0.016037451,-0.01809368,0.0048539666,0.030259399,-0.011080156,0.033078924,0.008605727,-0.024472354,-0.00074502337,0.047367785,-0.018729508,-0.019779395,-0.029478163,0.053531095,0.0009626414,0.027644249,-0.078591876,0.0018241857,0.019845149,0.0033774136,0.019888341,0.13325939,-0.045155734,0.028281866,0.017488228,0.020915423,0.01620538,-0.060214635,-0.03377474,-0.0065717963,0.03342837,-0.0142891565,-0.022662723,-0.02292309,0.050252058,-0.04796859,-0.06073336,-0.05630398,0.018522814,-0.0036722939,0.01549322,0.07334926,-0.03956743,0.020385524,-0.03534724,-0.047381848,0.034837335,0.03854523,-0.05427331,-0.04276831,0.054696415,-0.0055920756,-0.087177575,-0.027395206,0.037183423,-0.0024180238,-0.00055863673,-0.033805534,0.053458717,0.029999623,-0.007866981,-0.03215953,0.08845911,0.040785477,-0.01090928,0.009135147,-0.03239118,0.0041708583,-0.002567458,-0.0046319007,0.095391326,-5.2611245e-08,0.08296423,-0.05111486,0.0056557036,-0.060506053,0.019953283,0.055145856,-0.09289779,0.029143782,0.077846326,-0.032448694,-0.023795726,0.08565651,0.05718725,-0.016213922,-0.010619455,-0.008914925,-0.009897775,0.023455916,0.036661834,-0.0030444511,-0.08241042,0.024663296,-0.09728124,-0.007539676,0.07468187,-0.047196813,0.039282333,-0.0740375,-0.014755306,-0.08584037,-0.031023035,0.017313557,-0.050509732,-0.038026318,-0.019041764,-0.04978757,0.008808654,-0.04707372,0.011950489,0.040658742,0.08939341,-0.014335643,-0.049972966,-0.10008861,-0.00641634,0.0637845,-0.019999301,-0.008934996,-0.05248658,0.012579527,0.009188732,-0.02356518,0.027212795,-0.027871894,-0.10662235,-0.051405437,-0.025292352,-0.15775727,-0.011535276,-0.03294997,0.07279399,-0.017724117,0.15973462,-0.019296482 +2.7.7.79,"In eukarya an additional guanosine residue is added post-transcriptionally to the 5'-end of tRNAHis molecules. The addition occurs opposite a universally conserved adenosine73 and is thus the result of a non-templated 3'-5' addition reaction. The additional guanosine residue is an important determinant for aminoacylation by EC 6.1.1.21, histidine---tRNA ligase.The enzyme requires a divalent cation for activity [2]. ATP activation is not required when the substrate contains a 5'-triphosphate (ppp-tRNAHis) [3].",384,0.99999994,-0.045438927,-0.039076086,-0.09309525,-0.08334997,0.008270135,-0.002068028,0.037920382,0.0043529845,0.030592935,0.07905073,0.120056055,-0.07244954,-0.12056936,0.027991144,0.002293956,-0.008568468,-0.121898174,0.015114651,-0.0069443285,-0.13987972,0.031061325,0.06559518,-0.02566732,0.019650422,0.023271216,-0.015840031,0.06811566,-0.022393417,0.036738228,-0.037297804,-0.13427922,-0.06637848,0.012751733,-0.016868154,-0.025150765,0.08282399,-0.11213844,-0.0041803387,0.055079777,0.014925249,0.07922869,-0.021696473,-0.004922434,0.030268319,-0.068980694,-0.037641983,0.030347519,0.026554734,0.04054816,0.016301155,0.032161493,-0.03752378,-0.0433553,-0.026036581,0.03474817,-0.014345342,-0.08276145,-0.004778941,-0.0032044363,-0.016624743,0.07086585,-0.0065213074,-0.006491962,-0.048033454,0.037995398,-0.0708504,0.040433988,-0.045167092,0.009096592,0.051620536,-0.04043874,-0.03973488,-0.02452078,0.06711625,-0.068363085,0.08015666,-0.03216738,-0.008011556,-0.0380311,0.06491027,-0.013541051,-0.016557166,0.09630863,0.021256244,0.04663976,-0.009978549,-0.045297526,0.028774466,0.030993553,0.055022925,0.123875335,-0.01028018,0.016258327,-0.048479144,-0.05751685,0.06157856,0.009368076,-0.0022314559,-0.020598143,-0.021929888,-0.0009889309,0.06135127,-0.057725463,0.013071743,-0.006262383,0.012909594,0.024885407,0.037272196,-0.047785603,0.038288355,-0.021127578,0.023663485,0.029925622,-0.0498213,0.009428482,0.10835972,-9.888136e-05,-0.03405367,0.051332254,0.0013062509,-0.0016405476,0.032547377,0.0023009777,0.11133979,-0.07456708,-0.014007099,-0.061548177,1.9747111e-33,0.044490017,0.024101276,0.033388343,0.024546234,0.025797557,0.0058291825,-0.08962404,-0.04783606,-0.06583868,-0.05779219,-0.11912484,-0.03017764,0.02920469,-0.02389429,-0.027074663,0.025016345,-0.033318914,0.044874653,0.083666146,0.004963872,0.011665901,0.031498075,0.00991871,0.006363227,0.063205995,0.060398895,-0.014656267,0.010863837,0.03401171,0.0017911099,-0.052801087,-0.03201456,-0.086851396,0.0007479433,0.04224441,-0.046461847,-0.027621113,-0.0066209496,-0.007960863,0.065598994,0.014272861,0.023487197,-0.028883196,-0.0035950486,0.019141264,-0.03766202,0.024906825,0.039123837,-0.0004826047,0.018110232,0.00040622507,-0.028108764,0.05523538,-0.006945838,-0.036335282,-0.003846068,0.010443869,-0.038063075,0.057341594,0.06021329,0.03415327,0.011343842,0.012980625,0.026128968,-0.01115798,0.06355808,-0.12206351,-0.062691994,0.04097212,0.03830179,-0.03476585,-0.032836393,0.09850914,0.030602558,0.06354252,-0.04663882,-0.07692784,-0.03541088,-0.06650595,0.08087098,-0.01963866,-0.040300287,-0.0024348346,-0.007085095,0.009918201,-0.009238065,-0.039228845,-0.051617842,0.0203783,0.040637903,0.059823915,0.014646223,-0.099376604,0.024337817,0.02292661,-2.4867994e-33,0.07439054,-0.10139105,-0.01618924,-0.036146242,-0.09573906,0.06602727,0.014981642,-0.103551134,-0.007937356,-0.07455207,0.11151966,-0.0033333334,-0.08843897,0.013328508,-0.02566126,-0.060215835,-0.0443822,0.1058095,0.004277367,-0.060425803,0.058178276,-0.010659159,0.021690225,0.008479439,0.0626183,-0.03469761,-0.04404322,0.035371393,-0.011503007,0.0436251,-0.05783242,-0.019610083,-0.010621748,0.0772875,-0.016364435,-0.015177943,-0.014653027,0.07689535,0.020952793,0.032852326,0.05260769,-0.0005409806,0.067529656,0.09122437,0.011643171,0.0575289,-0.0007808081,0.041864235,-0.062044654,-0.11321222,0.077736184,-0.014913518,-0.028709773,0.014199387,0.06462784,0.04916446,0.017960496,-0.0088685695,0.099768735,0.0041424865,-0.0018002684,-0.080757864,-0.026501572,-0.10021428,0.09404066,0.030866409,-0.028585674,0.10287907,0.03764874,-0.0274326,-0.031321727,-0.030082937,0.02032947,-0.00084233406,-0.0062766457,-0.029490111,-0.008405016,-0.013104366,0.045412984,-0.03784555,-0.082821056,-0.014709385,-0.035923243,-0.06275226,0.04331863,-0.025284268,0.078895554,0.115891896,-0.015309817,0.08973146,-0.012158742,0.052112397,-0.032594103,0.08644416,0.02471601,-4.278714e-08,0.0030846384,-0.03109317,-0.06418237,-0.030814368,0.051261365,0.100437015,-0.038914666,0.05489803,0.07251128,-0.033777222,0.007200893,0.017522395,0.05309567,0.09278402,0.048732173,0.05760259,-0.05559094,0.008498933,0.011171631,-0.06641994,-0.09530749,0.0180434,-0.14277919,-0.0064648003,-0.016618183,0.013477036,0.011899074,0.15587631,-0.025662865,-0.051106766,0.028533107,-0.045084752,-0.0367627,0.040185098,-0.006631552,0.061514765,-0.020157348,-0.04760413,-0.029917585,0.0049725417,-0.06454438,-0.009406717,-0.059985273,0.028443724,0.009484311,0.043472987,0.006327987,0.07373796,-0.06327522,0.028125502,0.07221986,0.0016402454,0.07279582,-0.005926994,-0.044314917,-0.032365225,-0.005722358,-0.07796928,-0.06945451,0.019859856,0.04744901,-0.06676703,0.07035052,-0.05008869 +2.4.99.13,The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.12 [lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [2]. 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+2.5.1.154,"The corrinoid adenosylation pathway comprises three steps: (i) reduction of Co(III) within the corrinoid to Co(II) by a one-electron transfer. This can occur non-enzymically in the presence of dihydroflavin nucleotides or reduced flavoproteins [1]. (ii) Co(II) is bound by corrinoid adenosyltransferase, resulting in displacement of the lower axial ligand by an aromatic residue. The reduction potential of the 4-coordinate Co(II) intermediate is raised by ~250 mV compared with the free compound, bringing it to within physiological range. This is followed by a second single-electron transfer from either free dihydroflavins or the reduced flavin cofactor of flavoproteins, resulting in reduction to Co(I) [4]. (iii) the Co(I) conducts a nucleophilic attack on the adenosyl moiety of ATP, resulting in transfer of the deoxyadenosyl group and oxidation of the cobalt atom to Co(III) state. Three types of corrinoid adenosyltransferases, not related by sequence, have been described. In the anaerobic bacterium Salmonella enterica they are encoded by the cobA gene (a housekeeping enzyme involved in both the de novo biosynthesis and the salvage of adenosylcobalamin), the pduO gene (involved in (S)-propane-1,2-diol utilization), and the eutT gene (involved in ethanolamine utilization). The first two types, which produce triphosphate, are classified as EC 2.5.1.17, corrinoid adenosyltransferase, while the EutT type hydrolyses triphosphate to diphosphate and phosphate during catalysis and is thus classified separately.",384,1.0,0.008366156,0.0020990027,-0.08623766,-0.0043570003,0.040812064,-0.022396967,-0.051209074,-0.01889721,0.08533876,0.04114783,-0.00040524817,-0.018493058,-0.09663247,0.0050384984,-0.028254757,0.019803936,-0.06252926,0.0035718677,-0.005966349,-0.0027480584,-0.0021823456,-0.047960907,-0.040186305,0.017563537,-0.028287603,0.036355138,0.042489592,0.016334815,-0.022861514,-0.03384022,0.03718987,-0.0132118985,-0.04178768,-0.02364615,-0.012160867,0.08109934,-0.012550385,-0.055087276,0.05491345,0.05275189,0.043050427,0.0443879,0.040259387,0.055019908,-0.008055254,-0.029419482,-0.042642117,0.04742858,0.026839191,-0.02551978,0.0029835203,-0.0040232786,-0.0950091,-0.017192388,0.026489193,0.05318178,-0.114999026,-0.012378118,0.036508407,0.031458754,0.03654025,-0.086056724,0.055787947,0.037738647,0.04678174,-0.012969463,0.042186208,-0.12171517,0.0037190772,-0.033840176,-0.03049273,-0.0092544295,-0.009324573,-0.082160525,-0.005848055,0.08792131,-0.04010397,-0.015134576,-0.007671446,-0.055430334,0.08647884,0.07990122,0.117519334,-0.026057275,0.00998833,-0.011541078,-0.044754732,-0.04099034,-0.029876176,0.09382177,0.014663678,-0.021970512,0.042336177,0.0029419947,-0.006051128,0.016506232,0.1636971,0.049776684,-0.003699012,-0.020602355,0.015159065,0.02392813,-0.05085113,0.0012765931,-0.039772023,0.0041724076,0.058984555,0.059494697,-0.027089814,0.08781261,-0.07839334,0.08118498,0.006480006,-0.057006504,0.0024924811,0.16306075,-0.0014954074,-0.027522314,0.0053079803,0.0343766,0.01044839,-0.054098684,0.021046288,-0.010407821,-0.016659342,0.05554269,-0.036404133,5.715452e-33,0.05550144,0.079056874,0.018337319,0.0032871605,0.003120795,-0.060040608,-0.06267532,-0.016010586,-0.028243318,-0.039141525,-0.068593524,0.056307863,0.08768749,-0.092294075,-0.060941417,-0.02721105,-0.05271857,-0.007573041,0.061884455,-0.0040308638,0.034504503,0.022340663,-0.008323897,0.09802689,-0.004838764,0.027238948,-0.078448966,0.048063703,0.01033102,0.0017449933,-0.022346752,-0.06327268,-0.0932137,-0.039378766,0.018026462,-0.08577032,-0.116259456,-0.046178367,-0.012046656,0.06492055,-0.04275183,-0.02598632,-0.03229428,-0.011746687,0.035811808,-0.10100066,0.026198216,0.036526784,-0.027210835,0.075085625,-0.019712664,0.011373115,0.055519965,-0.002838373,-0.093451105,-0.06284868,0.022613889,-0.101308905,-0.0031536508,-0.011105341,0.03565221,0.02505312,0.0003979379,-0.024801236,-0.026401186,-0.0048715984,-0.07802495,-0.073041804,0.056562766,0.03225433,0.035895027,-0.0136156855,0.038771864,0.038603097,0.06922748,0.04425184,0.010219192,0.020030623,-0.03518219,-0.015465522,-0.012763286,0.080054,0.10304094,-0.04539798,0.027724765,-0.005617464,-0.06660163,-0.076429136,0.01973799,-0.020721195,0.003938213,-0.027271684,-0.009748617,-0.09717819,0.0500081,-6.706548e-33,0.10224527,-0.08112997,-0.009786224,-0.082722895,-0.06931807,0.102595836,0.00475636,-0.09329803,0.08577211,-0.058195807,0.06578131,0.047936786,-0.0066292435,-0.07647702,0.060120054,-0.0550723,-0.06554617,0.082955,0.004031023,-0.036597937,0.07173282,0.014138362,0.009541149,-0.00011664592,0.012810477,-0.021767087,-0.04302637,-0.07390238,0.048230615,0.09485693,-0.056389473,0.008009267,-0.04964559,0.07495613,0.05291539,-0.002683716,-0.028915567,0.046986595,-0.08301955,0.02875249,0.0025880842,0.023043396,0.057186548,0.014066966,0.051717058,0.061301474,-0.10257461,0.011672516,-0.0009426972,0.04254686,-0.0070937467,0.061263453,-0.124210365,0.052397437,0.08452603,0.09744357,0.07700734,0.006729225,0.037667025,-0.03190756,-0.0729344,-0.08893217,-0.015271358,-0.060641557,0.08493397,0.023552362,-0.012916852,0.03942498,0.058058336,0.009962273,-0.010607924,0.058908124,0.011232357,-0.025563776,-0.0011646332,-0.01335591,0.03902205,-0.0501171,-0.06464973,-0.030235806,-0.025016978,0.0004361503,0.050395165,-0.0740654,0.005405204,0.015404626,0.04314631,0.0061383243,-0.1009483,0.014850933,0.030752312,-0.05411905,0.010855044,-0.023924453,-0.015999753,-4.8877098e-08,-0.021278657,0.03837684,0.0019640783,-0.024435336,0.07158901,0.10975845,-0.0999421,-0.025309084,0.031707793,-0.058365304,0.009078298,0.06286673,0.085462205,0.028646613,0.024940228,0.017220953,-0.08107916,-0.020053346,-0.008916009,-0.046018843,-0.09733193,-0.044440467,-0.0836291,0.053584266,0.07212412,-0.006739358,0.06861278,0.01708367,-0.009498711,0.007575235,0.006747079,-0.014173711,0.0003172536,-0.028874034,-0.021532515,-0.042564787,0.02462956,0.07719212,-0.08521321,0.047168538,-0.031310424,-0.07371831,-0.041690324,0.06367277,0.074282765,0.080245525,0.016403763,0.05509325,-0.045035675,0.045284294,0.0050006253,-0.040644474,-0.035566244,0.01839079,-0.060439277,-0.021546025,0.0009941912,-0.04528862,0.009734631,-0.08055038,0.0028217325,-3.3048746e-05,0.08022386,-0.04094525 +2.7.7.78,"The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.",384,0.99999994,-0.0057655624,-0.015077435,-0.046233412,-0.006107391,0.013373042,0.0148763545,0.04401954,0.050290845,-0.037185006,0.025173556,0.006772766,0.105809614,-0.080413036,0.008989849,-0.070446484,-0.05857068,0.048354346,0.011918848,-0.049231615,0.017252915,0.1055727,-0.053552322,0.04715962,-8.835197e-05,0.05982846,-0.07028449,0.0011321103,-0.06519345,0.008787122,-0.067637056,-0.032996073,-0.049774513,0.04599058,-0.016903825,0.039734818,0.08118753,0.026273951,0.010320793,-0.0026037116,-0.07622541,0.018568587,-0.07763498,-0.043494247,-0.049839713,-0.042379573,0.011915908,-0.11560136,0.046815835,-0.011401571,0.050602287,-0.016725352,-0.05098382,-0.010318685,-0.000497375,0.041252833,0.023342663,-0.055634588,0.005189491,-0.01947203,-0.0024979068,-0.008424408,0.023618758,-0.0036328093,-0.0135308625,0.05703748,-0.10099381,0.07123238,-0.06469212,-0.0009465815,0.029672615,0.015356324,-0.09603103,-0.057162415,-0.06692331,0.01119355,0.034835644,-0.03000155,-0.05943417,0.07183281,-0.02772426,0.10538346,0.011595185,0.08800783,0.04733508,-0.033664234,-0.0055547706,0.031757332,-0.005909471,0.07784851,-0.032695767,0.0018949208,-0.00662943,0.014089161,0.0010515398,-0.03191388,-0.0150867775,-0.0071043177,0.012310291,0.030322967,0.015649693,0.057514656,0.05958711,0.009537226,-0.07101805,-0.09042193,0.030176941,-0.020419635,0.01663427,0.07309742,0.041214388,-0.006169043,0.1037798,0.053160824,0.06543095,-0.12193653,0.04466686,0.06555323,-0.062445935,-0.02186801,-0.00020505142,0.026995186,-0.004188722,0.09450628,0.035201028,0.0021435448,0.05534816,0.005270113,-1.1167542e-33,0.05170458,-0.043563604,-0.019810392,-0.023277875,0.017547192,0.056000207,-0.08817001,-0.032053206,0.012907329,0.021511452,-0.08869632,-0.06175293,-0.014590779,0.101376444,-0.0058604623,0.044060256,0.048067138,-0.0030702618,0.07345222,0.014050699,-0.0076761832,0.018604988,0.011903809,0.019568114,0.08167682,0.08889462,-0.09998261,0.07872493,0.07034294,0.031179385,0.09615051,-0.060595185,-0.06758883,-0.004940172,0.017137107,0.077590235,-0.060233813,-0.026344998,0.029193277,0.02681072,0.0027933023,0.012971042,0.02379944,-0.06620519,-0.025117258,0.016554914,0.055118468,0.04800891,0.0196647,0.03925097,-0.0015600376,-0.058939308,-0.027471665,-0.053076737,-0.022680406,0.075631715,-0.038300898,-0.08568111,0.05954092,0.07402961,-0.016189646,0.06024324,-0.034232154,0.033470128,-0.007822873,-0.022520257,-0.021612238,-0.00024213719,-0.050520174,-0.010889861,-0.09757838,-0.07988785,0.06316718,-0.011656814,-0.03886366,-0.06790734,0.04427302,0.0017353429,0.024199532,-0.056880094,0.033612233,-0.02330152,-0.02594879,-0.051789332,-0.072378024,0.01584328,-0.07837519,-0.0761016,-0.08581857,0.018744946,-0.030975338,0.016135415,-0.08345791,0.015863413,-0.034544274,-3.2563346e-33,0.07444183,-0.068024546,0.078794785,-0.05062741,-0.016762326,0.03561889,0.09369834,-0.10092995,0.034869943,-0.0319159,0.0054745562,-0.004866074,-0.011596092,-0.06366654,-0.007874398,0.052328024,-0.053925697,0.034940183,-0.10558231,-0.019172514,-0.040329743,0.102258004,0.034131385,0.05952975,0.035504058,-0.019252654,-0.016206045,0.030602904,0.049049903,0.001674565,0.03381578,0.00062908715,-0.04475673,-0.048302114,-0.03838394,-0.023047417,-0.034769993,0.023200557,-0.023313535,-0.058967352,-0.00655773,0.101349644,-0.037809137,-0.014179381,0.06747812,0.037756395,-0.06763179,-0.007012871,0.017109377,-0.029064866,0.027133923,-0.025471572,-0.021656327,0.019681124,0.006468646,0.07421454,0.0501211,-0.005497347,-0.07373009,0.019453468,-0.008039736,-0.024864918,0.05364609,-0.022247154,0.049671035,0.026037725,-0.009980686,0.031990487,0.11631588,0.017219337,0.03148911,-0.01727041,-0.030858248,-0.0014535821,-0.07333423,0.0011587577,-0.13409778,-0.049717925,0.0060925526,-0.05467174,0.017490098,0.03266219,-0.022192352,-0.040232155,0.014145001,-0.09194967,0.017111171,0.090392165,0.020664737,0.04356939,-0.12162294,-0.028875977,-0.020464044,0.046947706,0.056937013,-3.8244764e-08,0.08689883,-0.02321085,0.04714368,-0.020938024,-0.030909676,-0.04852627,-0.03456077,0.046167348,0.011610212,-0.022330232,-0.06682532,0.1512123,-0.071468584,-0.0155471,-0.020070352,-0.038966846,-0.071080655,0.0779775,-0.07086209,0.02666216,-0.08808825,0.020311724,-0.119323134,0.015016478,0.012332966,-0.07264176,0.073467,0.058572423,-0.07032273,0.022382293,-0.0005776134,0.025136495,0.05276027,-0.013860028,-0.06961481,-0.0012332628,-0.015670883,-0.019715428,-0.017527832,-0.0037530027,0.04278937,-0.021488033,0.05505341,0.018293226,-0.07363678,-0.019289998,-0.004165052,-0.009983518,-0.0065023242,0.11917699,0.012332814,0.051127274,-0.13554874,-0.023707833,-0.00619542,-0.036019973,-0.06492971,-0.054421082,-0.0059343744,-0.06455839,0.05837713,-0.016462153,0.14180002,-0.07714694 +2.4.99.14,The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes. 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+2.4.99.15,"The enzyme from Chlamydia psittaci transfers four Kdo residues to lipid A, forming a branched tetrasaccharide with the structure alpha-Kdo-(2,8)-[alpha-Kdo-(2,4)]-alpha-Kdo-(2,4)-alpha-Kdo (cf. EC 2.4.99.12 [lipid IVA 3-deoxy-D-manno-octulosonic acid transferase], EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase], and EC 2.4.99.14 [(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase]). 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+2.6.1.87,A pyridoxal 5'-phosphate enzyme.,384,1.0,-0.024376601,-0.08863048,-0.044111863,-0.053744897,0.028976228,-0.0255879,-0.03217151,-0.01701738,0.04872256,0.06807762,0.019534785,0.022200221,-0.102220505,0.08489369,-0.05379088,0.028953232,-0.074615024,0.0037539403,-0.0008179866,-0.07167688,0.084969856,0.015088342,0.013158346,0.027362937,0.005137274,0.06877674,0.05469736,0.035695024,-0.054798793,-0.06989291,-0.039161038,-0.014713177,-0.039460562,-0.10436785,0.02043322,0.089089476,-0.11029026,0.019260988,0.020687534,0.016282523,0.07414077,-0.08827551,-0.04104885,-0.0011729703,-0.09170401,-0.036378667,0.036437344,0.037279442,0.08510163,-0.015442928,-0.10219071,-0.035400234,-0.030128896,-0.08676717,-0.032329626,0.000994015,0.008929242,0.008426043,-0.02677478,-0.008450519,0.02069274,0.005727731,-0.010425993,0.022472845,-0.0069141896,-0.015646897,0.01919737,-0.075125545,-0.040324923,-0.0039844974,-0.08167265,-0.042505387,0.11115561,-0.034603182,-0.04184011,0.01952571,-0.007589896,-0.038378958,0.015666502,0.055683333,0.019385327,-0.013395795,0.013168021,0.048487324,0.054111674,0.07103269,0.035331015,0.02283578,0.004478671,-0.051385302,0.017140422,0.017074978,-0.024185713,-1.5630325e-05,-0.03980238,0.026653295,-0.03349968,0.012436865,-0.029321915,-0.054062095,0.029041234,0.0051403465,-0.017754905,-0.06844119,-0.049623944,0.013943716,-0.01191356,0.043089762,0.021693673,-0.007443862,-0.08452079,0.07360881,-0.025108647,0.030375838,0.019283317,0.053741664,0.0073536416,-0.03517853,-0.061739996,0.07300815,0.02833946,-0.041748844,-0.005106049,0.09894696,-0.08030762,-0.00667232,-0.06958128,-1.3223534e-33,0.05135789,0.09043385,0.04399726,0.009637854,-0.013935884,0.020230846,-0.071488485,-0.032794394,-0.113472,0.023826037,-0.009107332,-0.017589008,0.052454136,-0.02135114,-0.03268081,-0.035755448,-0.058158893,0.06878389,0.071051866,-0.023435842,0.07180854,0.08906534,-0.06963005,0.10478328,-0.0052495496,0.11064969,-0.029892042,0.0007580459,0.039390624,-0.019076066,0.004108195,-0.0852406,-0.061804876,-0.047434356,0.049484704,-0.07646069,-0.05774183,-0.012476759,-0.01058115,0.0134217525,-0.0069785244,-0.03522218,0.02777959,0.07386197,0.031299718,-0.10789865,-0.067499585,0.09708314,0.0044828374,0.045290474,0.031433616,-0.04182779,0.11310181,0.009385611,-0.09428313,-0.002501832,-0.037677493,-0.015366965,0.027847264,0.03139828,0.045528833,0.033966925,-0.06532455,-0.00050801586,-0.007047257,-0.013781518,0.059431043,-0.05093036,0.081665754,0.09140598,0.019837653,0.034602113,0.06110104,0.062177837,0.014744653,0.005389765,-0.0032971967,-0.0032665995,-0.011702157,0.054194346,-0.009902383,-0.08777781,-0.0022946387,-0.027946478,-0.049527362,-0.0035647398,-0.01375583,-0.040403783,0.029919991,0.024878174,0.052104242,-0.16081838,-0.05266967,0.0008201146,-0.022338877,3.0034645e-34,0.12276201,-0.08015871,0.09565337,-0.011080033,-0.06422533,0.0017654147,0.070968755,0.015714932,0.0153753115,0.019146308,0.034204595,0.017222967,0.04815711,-0.0058275354,0.0044911494,0.066947326,0.018598935,-0.0070332056,0.08152645,0.010710161,0.024762794,0.052171946,0.005262131,0.062321857,0.0908062,0.07714759,0.035150062,-0.0076900623,-0.04050927,-0.0044013816,-0.013583452,-0.007252974,0.0029851529,-0.047932994,-0.036320888,0.0057075014,-0.08043872,0.01979819,-0.021234108,0.021523954,-0.022291716,0.060466167,0.05228915,0.014652937,-0.05859067,0.025656497,-0.024708454,0.032248635,0.014711188,-0.060069334,-0.009603226,0.07551516,-0.050152484,-0.02641991,0.043226156,0.005615636,0.0014640646,-0.001497748,-0.016644485,0.0019861595,-0.003830944,-0.06372656,0.07513915,0.054873884,0.008974702,0.116247214,0.05200143,0.01590974,0.0049110726,0.03723374,0.02461822,0.034436647,0.05695441,0.09446491,-0.0519144,0.0010892372,0.0016188875,0.05730977,0.02583313,0.013828258,0.01609027,-0.021169402,-0.033270054,-0.13237968,0.0056117596,-0.100858204,0.08333845,0.112095594,0.045661364,0.030972224,0.022139015,-0.003251736,-0.018567683,0.004325473,0.08637934,-1.904004e-08,0.068661585,-0.048761584,0.037640728,-0.086729065,0.030115385,0.014027869,0.037398003,-0.037368678,0.09995159,-0.009828755,-0.015133356,-0.005386837,0.053093348,0.02034916,0.02360698,0.026822926,-0.027255964,-0.017572556,0.022934461,-0.060935013,-0.08729273,0.028803857,-0.12788701,-0.025926946,0.082052276,-0.014498811,-0.032158844,0.017898014,-0.022729935,0.0054988195,0.021326028,0.014115404,0.002875108,-0.084012635,-0.031089976,0.10079931,-0.04707081,-0.0122229215,-0.111087374,0.028300377,-0.059747,-0.06671505,0.018088948,-0.016922789,-0.022670256,0.021729793,-0.052948028,-0.03862538,0.006584859,-0.016479053,0.03249872,0.0033864172,-0.058332063,-0.078102924,-0.12383725,0.052634623,0.05421937,-0.068516254,-0.06625066,-0.09548189,-0.012567784,-0.03067304,0.13488537,-0.05521984 +2.7.1.166,The enzyme phosphorylates the 4-OH position of Kdo in (Kdo)-lipid IVA. ,384,0.99999994,-0.025875552,-0.014011981,-0.007845856,-0.046356253,-0.051619146,0.04656584,-0.04504219,-0.023763286,0.048151933,0.06841095,0.023897,-0.06905475,-0.088901184,0.056754094,0.010484982,0.046826374,-0.048947085,0.05691556,-0.032064423,0.0138218,0.08559061,0.0028117516,0.0116254,0.03393922,-0.02848181,0.06708831,0.09697414,-0.03175528,-0.034463968,-0.06826375,-0.08936589,-0.06807414,0.09129616,-0.039606087,-0.018439101,0.01648991,-0.025121288,-0.056745056,0.034576327,0.046003435,0.05989024,0.0033648121,-0.013783572,-0.016477112,0.025221488,0.002637487,-0.0039703464,-0.007116165,0.10425313,-0.0032626349,0.0035752296,-0.10714819,-0.03794326,0.116540544,-0.058284327,0.11680837,-0.12089476,0.036390524,0.012079831,0.10430482,0.032821707,-0.0013427137,0.098664366,0.085215114,0.053712077,-0.07558958,0.06614978,0.011713905,-0.058615375,-0.052720707,0.012156519,-0.0042867446,0.018993914,-0.022988161,0.061204694,1.0181761e-05,0.006317431,-0.016015477,0.031063695,-0.07711153,0.076923475,-0.014662383,-0.034573447,0.05306704,-0.027604066,-0.009392469,0.014531692,-0.06811623,0.020110857,0.049410485,0.04642626,-0.0532001,-0.039678074,-0.029428618,0.017855754,0.014011267,0.0552379,0.032844577,-0.017268902,-0.020558367,0.03427064,0.018433101,-0.0071223457,0.013755586,-0.0028147842,-0.012581742,0.012774491,-0.049618434,-0.09010431,0.05958908,0.018900838,0.0033751787,0.07887551,0.040128816,0.02462327,0.018469742,-0.027367458,-0.045633964,-0.04502406,-0.020967877,-0.026966967,-0.103934236,-0.018261625,0.067290306,-0.078662425,0.08173749,-0.00941264,-2.3955638e-33,0.064054094,-0.010197954,0.040829998,-0.0545473,-0.023376938,-0.10299217,-0.081209265,-0.018775126,-0.12262445,-0.039052397,-0.027250394,-0.04524647,0.050739802,0.001337254,-0.0038863167,0.0019082337,0.01481808,0.103061356,0.11178847,0.037716854,0.03554181,-0.051217187,-0.057700433,0.029633615,-0.0039557414,0.08200757,-0.060778394,-0.08629635,-0.06646801,0.003212748,-0.042670954,-0.058589395,-0.025730424,0.010986479,-0.002762775,-0.016499653,-0.036220588,-0.059387866,-0.008546527,-0.00754817,-0.037706785,-0.03218968,-0.039186355,-0.03517637,-0.04036097,-0.012628551,-0.10718924,-0.005665465,0.085448846,0.032823153,-0.017806113,-0.038695626,0.096935295,0.076127075,0.0044769337,0.009924079,-0.03222209,-0.05110001,0.010340993,-0.03243202,-0.028981373,0.06295094,-0.08105913,0.09186345,-0.003501386,-0.0023800773,-0.11816774,-0.08006393,0.025331628,0.057053484,-0.019551596,0.024823127,0.02041357,-0.0062277084,5.8652047e-05,-0.019428093,-0.027915148,0.017266413,-0.053849407,0.07853171,0.049580812,0.0008006111,0.0052140653,0.0028494664,0.018981172,0.0012702522,0.035686135,0.0036834811,0.020752583,0.0067094713,0.0078038815,-0.04206184,-0.022492971,-0.01241569,-0.013128774,-7.920585e-34,0.0764474,-0.079478644,0.074791685,-0.050342597,-0.022970024,0.12230585,0.061753448,0.04783682,0.040095866,-0.02631267,0.0646301,0.00174473,-0.03784025,-0.014958055,0.07404476,0.058544748,-0.10100009,-0.0099838665,0.023205882,-0.046765935,0.016397437,-0.015772324,0.014935139,0.07006344,0.069069885,-0.053059924,-0.015351261,0.09146838,-0.09066486,0.049778815,0.01644327,-0.075882204,-0.07632748,0.062771164,0.0041130967,0.02739604,-0.06256649,-0.0051544267,0.024365896,0.05766243,-0.0077135004,0.063865475,0.038475785,-0.023543628,-0.05003362,0.021800317,-0.01089387,0.08092318,0.025045695,-0.08550239,-0.012729191,0.033518154,-0.03458706,0.035331108,-0.011597505,0.08347812,0.031001009,0.049717054,-0.03326106,-0.0790951,-0.09118176,-0.14466795,0.0387968,0.006881654,-0.041860923,0.049403068,0.020774603,0.017716583,-0.04297464,-0.046217076,0.013882663,0.012934944,0.04136358,0.04233325,0.0019305995,-0.09069585,-0.07425087,-0.0533846,-0.026593829,-0.03465742,0.031298906,0.020636387,-0.011665997,-0.120469324,0.047266334,0.039074816,0.011964035,0.07768073,0.011329217,0.03423477,-0.009583965,-0.02168801,-0.14550106,-0.019268507,0.050001882,-2.4837128e-08,0.08709549,-0.069723345,0.0630529,-0.04885777,0.008170744,0.03156875,0.02179268,0.010007359,0.04990346,-0.07276948,0.07024955,0.082978345,0.03372541,0.023494951,0.049256764,0.009680155,-0.07845066,0.030900696,-0.027567035,-0.03473999,-0.012002819,-0.010787241,-0.05607328,-0.0024807358,0.030393789,0.03698741,-0.0053757555,0.05366784,-0.039538484,-0.012587678,0.09094201,-0.023063939,0.020545058,0.0098866215,-0.019787833,0.0050490564,0.0050863544,0.012630929,-0.10730076,0.06899501,-0.04025877,-0.101106405,-0.042364195,-0.0029661234,-0.039919473,0.06762089,-0.009643791,0.04067978,0.046034344,0.012256507,-0.088320725,0.010990793,-0.049327042,-0.012621091,-0.026202507,-0.020934815,-0.017853763,-0.045587603,-0.04739725,-0.01294902,0.037871044,0.03779084,0.13459836,-0.048505962 +2.7.1.167,"The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.7.70). The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. The enzyme selectively produces D-glycero-beta-D-manno-heptose 1,7-bisphosphate [5].",384,1.0,-0.031576324,-0.020813365,-0.06783162,-0.055128187,-0.037618227,0.023194797,-0.004290033,0.038624294,0.009394545,0.09359459,0.027189657,-0.011840284,-0.053989932,0.041200474,-0.012755049,-0.005756432,-0.016414497,-0.009023561,0.0150393555,-0.021134272,0.08006853,0.03950282,-0.07093176,-0.02175386,0.0785352,-0.023304526,0.032450218,-0.017193163,-0.028336264,-0.053269427,-0.025153913,-0.11024221,0.10508621,-0.047789454,0.115449466,0.12586975,0.006263034,-0.0115522975,0.08528349,-0.04866285,0.057134103,-0.013167514,0.0031602923,-0.035566352,-0.021658571,0.031112334,-0.011213336,0.06659506,0.059538122,-0.0035047273,-0.016029406,-0.013506496,-0.038846787,-0.044527978,0.0019857767,0.03849695,-0.032864872,0.03677679,0.013446418,-0.030324118,-0.020679414,-0.028499963,0.12906994,0.023054995,-0.015260015,-0.1277587,0.08373612,-0.035320114,0.0018759186,0.010094946,-0.04703432,-0.041516162,0.04782383,-0.005840488,0.015666502,-0.011956833,-0.017010048,-0.0440454,0.060289875,-0.10462587,0.07592572,-0.02126661,0.022856751,0.094809674,-0.046960764,-0.034141436,0.009987755,-0.0138051165,0.05038836,0.011964743,-0.012404424,-0.055716485,0.022229858,-0.079155184,-0.034346297,-0.01851394,0.0057602003,0.040850412,0.010994647,-0.07521223,0.003560892,0.0680727,-0.004110826,-0.0777249,-0.0036376365,0.027431319,-0.08645742,0.0758677,0.052072454,0.013374017,5.8686974e-06,0.087815516,0.090138346,-0.029451538,-0.07400394,0.048857998,-0.010176676,-0.06958513,-0.05397943,0.02345023,-0.030326553,-0.044589408,0.05790463,0.081916854,-0.037626952,0.058458105,-0.019758325,6.3022004e-34,0.054298583,0.004926138,0.04916116,-0.03806764,0.005543291,-0.094829895,-0.0835017,-0.04340928,-0.08836775,0.0068612723,-0.06071448,-0.100147106,0.024042841,0.069054686,-0.009197576,0.08004464,-0.03846453,0.014747987,0.011385677,0.022500427,-0.037606508,0.052565254,0.0058187577,-0.02701896,0.076440506,0.07201927,-0.013771665,0.028631128,-0.0019346293,-0.01342324,-0.012085906,-0.07168992,-0.06367188,0.00188662,0.1247614,-0.04128088,-0.06733675,-0.03430131,0.03940881,0.044918805,-0.007169183,0.028072443,-0.021730343,-0.057638925,0.041527,0.04731688,0.02836045,0.039741915,0.053318042,0.07522057,0.06646711,-0.036683906,0.08225154,0.011243075,-0.06883562,0.023282621,-0.020499824,-0.036952954,0.08366135,0.045196835,-0.03222296,0.037954666,-0.0826384,-0.045432977,0.013917548,-0.019150062,-0.03378568,-0.057225745,0.0149804605,-0.0012070364,-0.0070598423,-0.040135015,0.05135681,0.0182875,-0.0097097745,0.015228601,-0.009940662,0.03880964,-0.012610657,-0.005548186,0.046977803,0.057558216,0.00025819414,-0.10869846,-0.024885463,0.027662205,-0.036841907,-0.13022524,-0.03898996,0.05913757,-0.035100486,-0.030129816,-0.06292332,0.06029292,-0.04665842,-3.367558e-33,0.07139307,-0.077317685,0.08320719,-0.050710913,-0.08312368,0.07482552,0.030199172,-0.008047794,0.05369914,-0.009406449,0.026850991,0.015652472,0.05161706,-0.018219499,-0.011779524,0.02144301,-0.003717053,0.10033278,-0.0545062,-0.017176218,0.041523743,0.06229559,-0.0001203884,0.06625045,0.041417502,-0.022451937,-0.056478705,0.111672305,0.029920945,0.043209177,0.039723106,0.021532794,-0.070573956,-0.041138362,-0.054955285,-0.021925796,-0.12007272,0.056629118,-0.0038926855,-0.0031951852,-0.01931948,0.072319165,0.041701075,-0.058708075,-0.0012841481,0.075404294,-0.015211177,0.007670967,-0.065236695,-0.019729853,-0.014801389,-0.024613414,0.0043320507,0.036016323,0.015429746,0.09039937,-0.00048953696,0.115460075,-0.008311499,-0.015894027,-0.03744346,-0.089430064,0.09498894,-0.010500602,0.04283606,0.13408685,0.021100566,-0.028917886,0.008295596,-0.0141213965,-0.00545824,0.01439622,0.04760668,-0.0048933406,0.0054769106,0.043051377,-0.11675235,-0.083524294,0.022846308,-0.022796055,-0.03956364,0.040206138,-0.04287974,-0.005369302,-0.015325251,0.009364884,0.0024799576,0.09799076,-0.00081891095,0.055241287,-0.051912528,-0.026157668,-0.0504178,-0.0051840954,0.032654516,-4.9463026e-08,0.04668479,-0.05932032,0.0665155,-0.1202099,0.010513668,0.014927373,0.011996854,-0.01022701,0.04841158,-0.040223524,0.0021872725,0.036602758,-0.015622373,-0.076796964,-0.053553116,0.01422107,-0.054123424,0.041021965,-0.037211187,-0.02894461,-0.049784455,-0.035096597,-0.10372539,0.09124442,0.04590086,-0.080119275,0.08172879,0.011484106,-0.014530773,-0.001847107,-0.019395068,0.036529202,-0.045634583,-0.042877592,-0.012229334,-0.0073181046,-0.080206335,0.016722681,-0.0073172683,0.043009326,0.050582018,-0.018089505,0.021605354,0.013355539,-0.04536244,0.07560758,-0.017827693,0.043812115,-0.07414483,0.014404543,0.05193457,0.004851433,-0.08160164,-0.08238445,-0.11910828,-0.012479695,-0.023465121,-0.09237688,-0.004741252,-0.00034472297,0.0011243906,-0.033074237,0.1405089,-0.040396508 +2.7.1.168,"The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in Gram-positive bacteria. The enzyme is specific for the alpha-anomer.",384,0.99999994,-0.05946766,-0.045095548,-0.10781051,-0.031796463,0.011071949,0.06481693,-0.032336436,0.05515078,-0.0012827949,0.04506096,0.02149793,0.022337468,-0.07621934,0.041863978,-0.056694034,-0.009847043,-0.042774495,0.006078813,-0.029700883,-0.09781521,0.052294586,0.031443916,-0.035107337,-0.030511457,0.032877203,-0.070636235,-0.008765067,-0.066299275,0.017731376,-0.04660022,0.007490092,-0.0935163,0.13559039,0.0018999155,0.058938146,0.09650614,0.014689008,-0.04428814,0.04394575,-0.009472089,0.044472944,-0.04098224,-0.045681436,-0.030214934,-0.06980924,0.06995798,-0.005881391,0.07405049,0.00212383,0.011305778,-0.008598702,-0.019603185,-0.07455595,-0.06350841,-0.03903783,0.08213244,0.0022675318,-0.040045504,-0.030300884,-0.02888725,-0.014656197,-0.029756451,0.066877805,0.044507302,0.042850126,-0.12179518,0.10000248,-0.033808593,-0.060541622,-0.006208767,0.005472405,-0.099977694,-0.027325615,0.020559495,-0.016653841,0.015300495,-0.016897133,-0.029502705,0.08156379,-0.06500088,0.09003272,0.00019852743,0.07175835,0.11026703,-0.041630313,-0.012071424,0.015640998,-0.025997052,0.055957578,0.069214,-0.0015525871,-0.103031,0.009637522,-0.06845831,-0.018689271,-0.017162314,0.029723678,-0.0033106697,0.028557451,-0.06450549,0.0026964846,0.05623561,0.01869137,-0.050482653,-0.0816401,0.026433771,-0.08138467,0.043072853,0.07514018,0.042983305,0.02837301,0.06660706,0.09464034,-0.02715538,-0.04941168,0.015853325,0.010353033,-0.02512772,-0.004106287,-0.015281935,0.016574197,-0.020795826,0.012530399,0.0982979,-0.01460078,0.052425083,-0.044466544,-2.9728781e-33,0.0557022,0.065535404,0.0050411127,-0.013992966,-0.051813018,-0.016089734,-0.09350323,-0.020532638,-0.06682513,-0.0038420167,-0.10061459,-0.1074962,-0.001234954,0.09019104,0.0032498823,0.02688009,0.02230865,-0.0020667147,-0.026699467,0.013655116,-0.030697318,0.012772166,0.0029442275,-0.019310366,0.111691594,0.06498179,-0.033884842,0.009236244,0.0002343732,-0.015084899,0.022544289,-0.07287649,-0.080284,0.039742142,0.10929046,-0.031136498,-0.016887182,-0.039497215,0.03422202,0.038573913,-0.005671136,0.044271067,0.0010670614,-0.022651017,0.025789214,0.029601049,-0.008663291,0.05711998,0.05024783,0.050715197,0.023339944,-0.032939307,0.04555418,-0.0502775,-0.028732127,0.071863055,-0.06340449,-0.0389911,0.032178443,0.060144324,0.0026989153,0.06905083,-0.052801583,0.020379592,0.02385608,0.0041112294,0.014450874,-0.02497375,0.0016332276,0.03507198,-0.053070236,-0.020898145,0.11585741,0.03555463,-0.0169914,-0.033621255,-0.013712674,-0.009981954,0.011472308,-0.045838267,-0.04436544,0.020318376,-0.025290182,-0.03772824,-0.07675032,-0.0043114647,-0.02307126,-0.07291183,-0.038750738,0.01875374,0.03898949,-0.0431146,-0.06452076,0.07137339,-0.038218543,-1.1497153e-33,0.066167235,-0.14072633,0.05494361,-0.045454465,-0.07519484,0.042926565,0.04524947,-0.0138171045,0.0474762,0.035111718,0.01786426,0.00038843104,0.0027214836,-0.07452234,0.017929576,0.027897568,-0.025473835,0.106525026,-0.061955784,-0.008359406,-0.0014824361,0.033881627,0.033464327,0.012196187,0.037651256,-0.016173452,-0.059548218,0.102903895,0.01922451,0.04710692,0.042899147,0.011785122,-0.03285773,-0.07847459,-0.053007923,0.026851121,-0.014556877,0.035679705,0.0032793519,-0.05400493,0.050118376,0.113241784,0.03251135,0.030973883,0.06259947,0.06393381,-0.067755856,0.04527647,0.030588599,-0.07536975,-0.031383913,-0.03057138,0.024349842,0.040884256,-0.0056812386,0.072806135,0.0223598,-0.016866261,-0.06979319,-0.04017264,-0.051748145,-0.0745833,0.07940375,0.004120015,0.020732027,0.041717544,0.020671416,-0.017614737,0.097859435,-0.015513101,0.005502703,-0.034226444,0.006085003,0.037673846,-0.018941728,-0.0116776675,-0.11268667,-0.07569344,0.046469722,-0.02211118,-0.049217284,0.06785949,-0.021896858,-0.00399965,0.035259485,-0.05136253,0.0561598,0.1326253,0.03379644,0.026909137,-0.050028373,-0.01793376,-0.030424593,0.05048613,0.028453473,-3.664528e-08,0.093504176,-0.083355926,0.07890473,-0.11228135,0.034183457,0.004922783,0.009486903,0.0035762717,0.04806733,-0.033106387,-0.068584286,0.07280968,-0.032689646,-0.06669336,0.034305822,0.051644444,-0.071730904,0.059231568,-0.06104797,-0.013491411,-0.07569005,-0.02225378,-0.12342617,0.050029464,0.006525149,-0.05570823,0.030919634,0.03407579,-0.04880987,0.020839728,-0.016537068,0.02942348,-0.045855664,-0.031703494,-0.07033552,0.008679773,-0.0056908354,-0.0563673,0.0644341,-0.025523795,0.013326365,0.015482386,0.005287966,0.042179044,0.007995352,0.04362112,-0.04686789,-0.031321913,-0.045184936,0.04211075,0.0056589856,-0.0048559043,-0.055073176,-0.04354633,-0.09255141,-0.060344625,-0.023519812,-0.07891161,0.010778446,-0.035767447,0.016755188,0.014629185,0.18214744,-0.085363336 +2.7.7.70,"The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.1.167). The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.",384,1.0,-0.04983745,-0.021218788,-0.064344466,-0.056105983,-0.062357802,0.031268273,-0.016259188,0.06205385,0.007180383,0.073397875,0.037443474,-0.0227823,-0.06601357,0.049736604,-0.009353195,-0.0013175581,-0.045109253,0.012730359,0.014056119,-0.024518762,0.06821505,0.056261297,-0.07819184,-0.026790667,0.06227178,-0.014364644,0.017998088,-0.005575934,-0.016954884,-0.055082355,-0.01395598,-0.100819826,0.10220305,-0.041945886,0.12717147,0.1332346,0.016141368,-0.03115425,0.09106589,-0.040217746,0.058409855,-0.0146944225,-0.014564825,-0.021162972,-0.00414652,0.039473847,-0.0050735534,0.057512343,0.06752079,0.0035841544,-0.01194965,-0.0068680523,-0.03248508,-0.036322348,-0.011867798,0.05302371,-0.033300627,0.011616495,0.029634167,-0.037602857,-0.020907948,-0.016365442,0.14642012,0.028746964,-0.010860886,-0.14243023,0.09009814,-0.036374483,-0.0059285825,0.025836978,-0.052872926,-0.04471636,0.025287298,-0.0058342884,0.016464211,-0.023521546,-0.028572828,-0.066557124,0.04935199,-0.101586595,0.080667384,-0.0081915185,0.0077476352,0.11121801,-0.037726745,-0.055916175,0.0127807455,-0.03748618,0.027723955,0.010976363,-0.028438719,-0.05988713,0.01313772,-0.069152094,-0.035758927,-0.021974532,0.017928254,0.059579086,0.0032065562,-0.076644056,-0.019307783,0.062240142,-0.0048179063,-0.0765123,-0.0005545966,-0.0094311135,-0.08063457,0.09282545,0.07712432,0.009180963,0.0006056318,0.077103615,0.09518596,-0.047024336,-0.058450844,0.043395396,-0.013758471,-0.07223603,-0.05554303,0.015040069,-0.04490407,-0.050634235,0.054685693,0.060601786,-0.025962543,0.020017818,0.004285498,8.92405e-34,0.06379903,-0.0088096615,0.047385253,-0.033741336,0.0018952452,-0.10882337,-0.09531566,-0.05663747,-0.07311952,-0.0056871334,-0.059510507,-0.10884205,0.01564072,0.073208235,-0.039780773,0.079385854,-0.040709056,0.013200402,-0.0020254822,0.03396745,-0.042849,0.053917117,0.020530097,-0.017044,0.06996423,0.05316915,0.0038320795,-0.0058951457,-0.013563731,-0.00038319174,-0.022823326,-0.07164375,-0.07504679,-0.003961822,0.11926765,-0.032083094,-0.06726206,-0.036416885,0.014472942,0.019285837,-0.02174606,0.04899355,-0.018556587,-0.06799067,0.04336153,0.05233263,0.038118787,0.038969036,0.04171175,0.07659597,0.06542812,-0.030352494,0.06504119,0.015465234,-0.04930118,0.02464917,-0.02466744,-0.016890427,0.068617515,0.052665234,-0.025758391,0.048265997,-0.09012236,-0.029620156,0.0072021484,-0.017894795,-0.030481901,-0.052619636,0.029737653,0.0021292884,-0.005087884,-0.035628665,0.05043379,0.025369532,-0.028585035,0.025757309,-0.018744273,0.020233355,-0.011906784,0.0039192564,0.040760834,0.035563152,0.024727117,-0.11692635,-0.009954656,0.021665348,-0.046714973,-0.10312419,-0.027144594,0.05796675,-0.011130537,-0.015881633,-0.051468898,0.041763783,-0.04386818,-3.8774993e-33,0.05454938,-0.07651753,0.065759495,-0.045122545,-0.089170605,0.08413519,0.008911818,0.030138034,0.036615197,0.008842873,0.050849307,0.03387207,0.03451583,-0.033224512,0.0022513065,0.015597591,-0.0074776104,0.090803355,-0.06004036,-0.003396254,0.01716693,0.044950336,3.220706e-05,0.062133685,0.03155466,-0.006472761,-0.07427096,0.1071206,0.033225663,0.028796477,0.058480486,0.012595344,-0.08205209,-0.024539404,-0.03871227,-0.034678943,-0.09823933,0.061566632,-0.0184163,-0.022583526,-0.003807531,0.05168534,0.042146247,-0.061022345,0.0027154884,0.08594459,-0.021102656,0.0048286957,-0.059976663,-0.0056776134,-0.019355264,-0.013645883,0.0128996745,0.029585697,0.008915717,0.09817778,-0.0037632724,0.120346375,-0.005642827,-0.015148019,-0.037078634,-0.067937374,0.09594042,0.00048527826,0.043640357,0.12050806,0.014136477,-0.03511584,0.0038363459,-0.016958456,0.007627461,0.025442054,0.046671055,-0.0043871203,0.0051484834,0.03201296,-0.11824163,-0.095220506,0.026392674,-0.007713665,-0.038259905,0.040382333,-0.044677258,-0.0059441742,-0.010777495,0.005707214,-0.008916079,0.09566391,-0.016255908,0.03977758,-0.04466532,-0.022172516,-0.06986426,-0.0045663947,0.017976841,-4.9897572e-08,0.04566025,-0.0615358,0.077052504,-0.12413666,0.010689363,0.01768267,0.00051946077,0.018368775,0.05585805,-0.003932388,0.008477462,0.036958206,-0.024707846,-0.0773109,-0.06504449,0.01348484,-0.040364627,0.03136564,-0.037093405,-0.048007287,-0.059970785,-0.027186444,-0.09026806,0.104536034,0.034677193,-0.071693,0.09648014,0.009064511,-0.013852913,-0.031812422,-0.003469943,0.039605815,-0.0383391,-0.013312011,-0.023416625,-0.017607283,-0.06021071,0.0077620586,0.0041571236,0.06569875,0.05678762,-0.0041024154,0.011277854,0.0028007345,-0.02438941,0.10061435,-0.012640105,0.043482628,-0.09223927,-0.0023161343,0.052720163,3.302855e-05,-0.08996677,-0.061351694,-0.119982824,0.0050676907,-0.014583981,-0.11223457,0.024628628,-0.00048008614,-0.006323261,-0.030201592,0.13823119,-0.032820474 +2.7.7.71,"The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. ",384,1.0,-0.04341548,-0.03508561,-0.10583233,-0.021727221,0.005980179,0.08133001,-0.03028608,0.061659515,-0.020762619,0.026573436,0.0057700872,0.013124623,-0.048740506,0.024330191,-0.04545579,-0.059577763,0.0048386115,0.022908567,-0.03964749,-0.04883156,0.09678471,0.03421698,-0.044043444,-0.04438501,0.057451516,-0.049118403,-0.014762137,-0.06377979,0.019624662,-0.044466488,-0.021016115,-0.08629018,0.10974824,-0.023283135,0.08691306,0.0752317,0.03945646,-0.024537174,0.055788152,-0.039392255,0.013517063,-0.02983164,-0.050913196,-0.049146518,-0.05720895,0.0614955,0.02352997,0.076416925,0.006752191,-0.010422076,-0.006254891,-0.025055947,-0.072168835,-0.027561933,0.0007953399,0.07456714,-0.016936533,-0.03529988,-0.024248855,-0.051723674,-0.0142246075,-0.032279696,0.0961785,0.03385306,0.0522463,-0.12959121,0.07677166,-0.018307872,-0.023637434,0.0053595277,0.008100608,-0.07050814,-0.023350354,0.040249623,-0.015099426,0.018184936,-0.007664628,-0.04236705,0.08704591,-0.0726869,0.08220371,-0.00033114094,0.048479713,0.08421784,-0.06255324,-0.020596473,0.014900336,-0.015349323,0.04558209,0.043744683,0.004841941,-0.100308746,0.0046699266,-0.08838166,-0.011352901,-0.025799595,0.02478193,-0.001464744,0.032212462,-0.07800285,0.0054532215,0.05014705,0.037397105,-0.0630208,-0.048719276,0.02126966,-0.07417565,0.07648782,0.04713047,0.014790579,0.028479278,0.081531845,0.069510765,-0.021799713,-0.061727546,-0.003018671,0.034886964,-0.050724268,-0.05606758,-0.011548829,0.0085698,-0.0027383494,0.02332477,0.083129786,-0.021106027,0.044738676,0.0049911784,-2.8331899e-33,0.057403278,0.038374905,-0.0035426288,-0.023221605,-0.028995177,-0.04100407,-0.07832282,-0.039765373,-0.07435697,0.03848744,-0.11193503,-0.10314772,-0.011494354,0.112195306,-0.016798276,0.06495577,0.020780679,-0.017904934,0.0062534763,-0.0040200176,-0.021903792,0.013098129,0.044912368,-0.041719984,0.10241921,0.07190173,-0.012609857,0.021342836,0.021125378,-0.00302424,0.037909824,-0.08197969,-0.047247797,0.013772453,0.10845866,-0.013772978,-0.023624482,-0.046599712,0.04715224,0.042198826,0.02314612,0.04804876,-0.021990549,-0.028421005,0.0049502077,0.052044973,-0.01407071,0.06180887,0.044787172,0.05886901,0.03236911,-0.04779134,0.051642943,-0.05483571,-0.04505328,0.05771347,-0.033845086,-0.036730483,0.027225066,0.052635364,-0.019949581,0.06857929,-0.06818975,0.028898124,0.053345196,0.0019157244,-0.0077119297,0.016805135,0.001129322,0.00515852,-0.06262955,-0.057798557,0.0832833,0.03219015,-0.022425603,-0.06246224,-0.001878204,-0.023996186,0.018398525,-0.005663558,-0.019704292,0.039845325,-0.073623955,-0.07122087,-0.040933046,0.005245824,-0.06651491,-0.09870066,-0.06558272,0.047561336,0.007884113,-0.0350599,-0.032969367,0.07673501,-0.061968315,-1.9556439e-33,0.06699723,-0.14400028,0.07223144,-0.019208865,-0.060637683,0.04506432,0.013662665,-0.022850977,0.016187072,0.039653685,0.019971741,-0.0029692247,0.003796419,-0.044491008,-0.006432584,0.021949073,-0.045130666,0.07245297,-0.04682451,-0.021529652,-0.007679142,0.0049937842,0.026310097,0.018889755,0.055488154,-0.02073073,-0.073741704,0.11290317,0.022860581,0.04938401,0.05791196,0.00077171694,-0.050830923,-0.054041743,-0.06920761,0.018750649,-0.034155983,0.041393943,0.030296491,-0.07206105,0.026403388,0.10094576,0.027800303,0.005532628,0.06749952,0.035519626,-0.06834674,0.015120737,0.029925225,-0.063679054,-0.026991975,-0.026207296,-0.013315565,0.032645836,0.023727525,0.07208585,0.004324468,0.018260952,-0.036558643,-0.05498414,-0.05954099,-0.09069133,0.07788912,-0.013278827,0.045732927,0.08950671,0.015128119,-0.021275638,0.09458395,-0.021259936,0.021092307,-0.04355257,0.0068615503,-0.0020666814,-0.028311871,0.00998578,-0.13739738,-0.038942706,0.045192443,-0.015059129,-0.018913945,0.039070677,-0.035003956,-0.00091647194,0.038126923,-0.06866556,0.054538824,0.14950414,0.021541404,0.044871997,-0.07482389,-0.033326015,-0.022120558,0.03311039,0.024401264,-3.6150656e-08,0.0782118,-0.07746924,0.09608517,-0.10150225,0.02886822,0.026767047,-0.003974558,0.0069271154,0.053773366,-0.039699942,-0.046538588,0.052851103,-0.03684608,-0.0945811,0.034011748,0.04450438,-0.11541486,0.061534796,-0.05242061,-0.016181888,-0.07714314,-0.0224069,-0.1137659,0.08459743,0.029008735,-0.06234031,0.044350013,0.03839713,-0.055374168,0.017373923,-0.011148628,0.02685232,-0.069089144,-0.002403075,-0.058094557,-0.03082035,-0.04493373,-0.01971387,0.065221414,-0.029243229,0.025430059,0.04151429,0.009068622,0.028367303,-0.0011062393,0.053680263,-0.03495343,0.025968362,-0.06924706,0.039498247,-0.007908511,-0.01671876,-0.069090985,-0.030965254,-0.092354454,-0.013702049,-0.010792595,-0.09371051,-0.017988183,0.0009485047,-0.008056006,0.012622979,0.16250126,-0.06970866 +3.1.3.81,"The bifunctional enzyme catalyses the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. phosphatidate phosphatase (EC 3.1.3.4)). It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signalling role in stress response [6]. The phosphatase activity of the bifunctional enzyme is Mg2+-independent and N-ethylmaleimide-insensitive and is distinct from the Mg2+-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4 (phosphatidate phosphatase) [5].The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase [4]. ",384,1.0,-0.05026962,0.0060768137,-0.021392837,0.026732393,0.081756376,-0.020979475,0.01931127,0.017866071,0.010938932,-0.004863235,-0.05537089,0.02530603,0.051798612,-4.5811735e-06,0.021615783,0.014624614,-0.006728374,0.04767506,-0.046452325,-0.0002120048,0.110419445,-0.02588223,-0.03895275,0.031088699,-0.027911143,-0.063173726,0.07176243,0.017789401,-0.06281458,-0.0031597218,-0.110077985,-0.0194661,0.050023798,-0.035459124,0.024780445,0.08641411,0.01704715,0.028774602,-0.045659877,-0.028989693,0.027817002,0.06668934,-0.02295236,-0.006606004,-0.017440978,0.022562707,0.04096615,0.016629169,-0.007314098,-0.043670926,-0.053065818,-0.01825939,0.030017981,-0.0331311,-0.020801539,0.060885478,-0.123326205,0.02364982,-0.029570572,-0.05380212,-0.09360383,-0.091744766,0.013568323,-0.0015594517,0.07053817,-0.029761987,0.044043865,-0.027809978,-0.03273761,-0.028367262,-0.056828298,-0.01594561,0.005021657,-0.012149339,-0.028814994,0.10003593,0.09826351,-0.052678324,0.018706359,-0.047600992,0.07236188,-0.03200534,0.023924677,0.023736851,0.020663666,-0.0021095076,-0.016746964,0.056793462,-0.0045024115,0.08597725,0.07113565,-0.02788157,0.027496047,0.06431579,-0.01221859,0.05142733,-0.06443335,0.06436203,0.047686562,-0.023868348,0.04425418,0.08206914,0.0037037684,-0.00812395,0.05629563,0.06302901,0.033338197,0.015064704,-0.016624946,0.1104278,0.03380582,-0.03729001,0.058892414,0.0018802836,-0.033637285,0.034844104,-0.051188692,-0.012115616,-0.05564958,-0.05193701,0.032201186,-0.036398754,-0.03372699,-0.035846867,-0.025437534,0.09696833,-0.01562825,7.84425e-33,0.006392466,0.024323875,-0.00051507883,-0.03278453,0.021881564,0.010288857,-0.010787269,0.07446074,-0.03185476,-0.07062196,-0.029290982,-0.068840176,0.011232739,-0.04878435,-0.117494985,-0.032699067,0.041880533,0.061719388,0.103045315,0.032588247,0.00534753,-0.08084825,-0.046213746,-0.034658,-0.008572375,0.061063692,-0.053803228,-0.018205922,-0.027021958,-0.0351601,0.027159907,-0.123708904,-0.023401773,-0.058165636,0.13554844,-0.05973585,-0.012944323,0.0142613435,-0.027171824,-0.051441386,-0.08969932,-0.055656426,-0.06799207,0.060996216,-0.026973277,-0.082084194,-0.113182664,0.053835016,0.039005473,0.023131885,0.04016872,0.0075475513,0.08071971,-0.04328955,-0.054465994,-0.008988471,-0.0383997,-0.06448651,0.025960788,0.029288381,0.0011348926,0.05816901,-0.045214087,0.05802983,0.06833651,0.019380314,-0.15233573,-0.060069147,-0.040509477,0.104961686,0.022041535,-0.06707504,0.04522894,0.03351843,-0.03729139,-0.026825845,-0.001570694,0.01183507,-0.03317427,0.01941572,0.049032502,-0.06321744,-0.027594743,0.04681972,-0.07292334,0.0075510447,-0.0026752248,-0.05185428,0.012254516,-0.029478699,0.006455962,-0.023332532,0.005483523,0.06166292,0.005264072,-8.03655e-33,0.099775895,0.010967998,0.053709302,-0.10135104,0.01452544,0.031149587,0.046560176,-0.031318296,0.06005587,-0.069296844,0.029294878,-0.044330176,0.015537559,0.030443328,-0.03977678,0.02082819,-0.07213169,0.10467367,-0.007860028,-0.033932623,-0.013254154,0.09874837,-0.014196049,0.13565472,0.07163727,-0.011226074,-0.031191295,0.05476073,0.0038263623,0.14275311,-0.00036252916,0.109475985,-0.0389183,-0.04063079,-0.006351244,0.06647411,-0.02742484,-0.030489262,-0.006178267,0.054187637,-0.0233408,0.06408311,0.03422323,-0.026295584,0.06901212,0.09280733,-0.026644457,0.048026968,-0.044286504,0.021161022,-0.024514476,0.055264175,-0.038689747,0.09166146,0.11779316,0.06462335,-0.019320728,0.053668533,0.033133026,-0.095219664,-0.07155037,-0.10235904,-0.027923768,-0.0094808005,0.022163942,-0.00068430236,0.019557472,-0.022660945,0.04021992,0.051586207,-0.027793208,0.10342113,-0.008060337,-0.00826872,-0.08280613,0.060317066,-0.038081698,-0.028087512,-0.018573392,0.009288965,0.019051798,0.04134193,0.005972524,-0.0018101911,-0.08178167,-0.012611353,-0.028682254,0.054902725,-0.06433137,-0.036700297,-0.075858705,-0.12697288,-0.08003778,0.033409473,-0.07829431,-5.015299e-08,0.037030216,-0.02592664,-0.016970567,-0.0757292,-0.016864482,-0.037348643,0.062039934,-0.046746045,0.053464588,-0.041600592,0.04616239,0.01794061,0.050807323,-0.024394069,0.06937114,0.016674835,-0.01080308,0.027533907,0.004384371,0.013752049,0.06876865,-0.037802234,-0.08942983,0.08718772,0.07561133,-0.052144572,0.02926348,0.042349957,0.02006408,0.006407718,0.019819489,-0.0132228965,0.053097934,-0.027660085,0.008398162,-0.0031830154,-0.05974154,0.007259491,-0.074503094,0.065248825,-0.07305435,-0.01424736,-0.0022189533,0.00755022,-0.027945641,-0.054614607,0.016833564,0.065563604,-0.028505398,-0.030473541,-0.029935177,-0.013920515,-0.033445485,-0.023811413,-0.04065807,-0.017041933,-0.03989045,-0.024297426,-0.048194714,-0.03021532,0.01171059,0.060659077,0.08741594,-0.10938995 +3.1.3.82,"The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. In vitro the catalytic efficiency with the beta-anomer is 100-200-fold higher than with the alpha-anomer [3].",384,0.99999994,-0.060892172,-0.0718393,-0.10617769,-0.011388172,-0.03798258,0.03444542,-0.037724398,0.044311162,-0.010635016,0.07089566,0.032958087,0.016634045,-0.0744564,0.03914666,-0.034877565,0.014650632,-0.013159987,-0.043463238,0.007931835,-0.031776562,0.023492882,-0.016466713,-0.068706445,-0.05532111,0.0686284,-0.040255267,-0.034931302,-0.06620308,-0.032517042,-0.032742683,0.027093597,-0.09471954,0.10833981,-0.08562534,0.07131236,0.07809768,-0.019127194,-0.019675462,0.08358168,-0.016397292,0.03662424,-0.026884606,-0.02716576,-0.03437702,-0.008919879,0.026330473,-0.040987127,0.043717537,0.0998991,-0.037911795,-0.036546983,0.019263424,-0.062546,-0.090637706,-0.07272912,0.058385238,0.015771993,-0.021673113,-0.030885171,-0.018154142,0.0001546271,0.0042094616,0.0740117,0.044878297,-0.032734793,-0.1189449,0.10360848,-0.0797323,-0.023197573,0.04987242,-0.034258857,-0.078975,-0.008430297,-0.032937303,0.028385602,0.015189695,-0.0055122795,-0.034485206,0.044854283,-0.052972652,0.09165281,-0.0077270526,0.0141986655,0.13213968,-0.041552227,-0.03480406,0.036417164,-0.041392144,0.07137856,0.072751045,-0.017617013,-0.046799336,0.008893259,-0.04782994,-0.059684657,-0.013770845,0.020954326,0.03210295,0.024003623,-0.06534358,-0.02859651,0.030652951,-0.011440203,-0.116232134,-0.052149612,0.029223766,-0.06020425,0.036743946,0.117456146,0.034837745,0.03209482,0.052243043,0.0900375,-0.04612812,-0.050992437,0.029618876,-0.016802631,-0.055101324,-0.009590273,0.012324,-0.0033599364,-0.07015353,0.0120471185,0.06074174,-0.01949678,0.04954301,-0.061052762,-1.8348249e-33,0.038144145,0.062084083,0.05947679,-0.060033508,-0.010349351,-0.057463434,-0.11861214,-0.05797655,-0.06758054,-0.0055159507,-0.033524755,-0.15030544,-0.014387234,0.094461344,0.005687538,0.033155747,0.006669709,0.016606132,-0.012551676,0.014242274,-0.058443643,0.031100381,-0.017755574,-0.00997807,0.13916585,0.052523423,-0.007992256,-0.0016720534,-0.029753176,-0.007024415,0.008466457,-0.04136984,-0.097691536,0.04166547,0.13518956,-0.028220246,-0.03813317,-0.040790044,0.043876547,0.03539059,0.007126252,0.08185327,0.030597012,-0.018747833,0.02607736,0.09625905,-0.011105768,0.048080377,0.07233881,0.026354322,0.047992606,-0.017420193,0.06440632,0.05595733,-0.020135233,0.072729856,-0.059348404,-0.0136625515,0.0668011,0.053148773,-0.02550681,0.048915062,-0.064497955,-0.024244783,-0.023063606,0.011860109,-0.0027442384,-0.034533378,0.03354073,0.013458457,-0.040825732,-0.010777607,0.07495515,0.041874822,-0.0074771605,0.009780505,0.016407382,0.004200018,0.03202838,-0.06754292,0.008616178,0.048314534,0.00047593116,-0.048176028,0.0063463813,0.026232341,-0.04200721,-0.032606646,0.03163246,0.040701237,0.018848013,-0.03785807,-0.056661744,0.053541064,-0.09897424,-2.133796e-33,0.062070385,-0.13706058,0.05066262,-0.0610228,-0.07434976,0.048595916,0.022212833,-0.0126399705,0.05316096,0.006570342,0.018375052,0.028506074,0.053502586,-0.010596895,0.01771536,0.031021124,0.023154955,0.092311755,-0.077368945,-0.04754999,0.047341827,0.029824182,0.03524342,0.034936864,0.025716964,-0.055107545,-0.08665624,0.11247271,0.0416763,0.031818062,0.029380241,0.022952624,-0.042528044,-0.094221026,-0.03966581,0.023333663,-0.06376401,0.040755462,0.028888337,0.030762913,0.010550555,0.066067435,0.04589356,-0.027009768,0.034304444,0.037165407,-0.05882986,0.005537371,-0.015855882,-0.041939616,-0.023756146,-0.05307231,0.06039696,0.03625375,-0.017288253,0.076205224,0.046369337,0.015535935,-0.00042148956,-0.05522019,-0.032360498,-0.053110313,0.10115382,0.012193977,0.005511205,0.10671344,0.071684614,-0.052665234,-0.010399049,-0.040312752,-0.036992677,0.0012682963,0.0043378533,0.073305555,0.01770945,0.016363874,-0.098154545,-0.11037641,0.017688636,-0.012505638,-0.034348268,0.06163497,-0.010934962,-0.025027111,-0.01798238,-0.026138574,0.027373374,0.098719716,0.009881053,0.037069112,-0.0010460744,0.012719033,-0.00072898716,-0.00042495734,0.07345046,-4.098737e-08,0.06138528,-0.03606008,0.07825347,-0.1104425,-0.018707529,-0.008757038,0.012981466,-0.03915317,0.05700497,-0.04835277,-0.014870362,0.07474568,-0.025136733,-0.030554526,-0.037855286,0.032838583,-0.043941427,-0.0016903926,-0.037872683,-0.023639204,-0.070806324,0.0012785338,-0.1054546,0.049661968,-0.011194518,-0.057350468,0.057800204,-0.013993131,-0.03800457,0.0039070197,-0.048221864,0.09308362,-0.06652202,-0.039632283,-0.051208887,-0.026012247,-0.041160703,-0.05679243,0.03281198,0.015403294,0.041706257,-0.008879016,0.023563566,0.016490325,-0.013884166,0.040451866,-0.04488876,-0.010933652,-0.05722323,0.02716528,0.052368715,0.024723846,-0.071455285,-0.069137774,-0.07896307,-0.037552804,-0.06363985,-0.025050582,0.0028172082,-0.013538364,0.0071153496,-0.012577703,0.14721036,-0.06863461 +3.1.3.83,"The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. The in vitro catalytic efficiency of the enzyme from Bacteroides thetaiotaomicron is 6-fold higher with the alpha-anomer than with the beta-anomer [1].",384,0.99999994,-0.06442035,-0.06933432,-0.101378225,-0.013705002,0.0038530633,0.0689925,-0.05816615,0.053059004,0.0037702888,0.030913139,0.018951023,0.059598792,-0.0005603469,0.033938777,-0.03678838,-0.0029705758,-0.03470335,0.003361412,-0.004469154,-0.09422715,0.029128851,-0.016237712,-0.04110863,-0.02577086,0.07226072,-0.07669959,-0.028467365,-0.08220288,-0.009454212,-0.028919026,-0.016325826,-0.06674976,0.10943852,-0.06597481,0.040681854,0.06570242,-0.0018717537,-0.03842433,0.041951917,0.0033982256,0.028570367,-0.0028082475,-0.0313202,-0.094436176,-0.09088918,0.01951583,0.031640097,0.051464763,0.082555205,-0.017240388,-0.03965774,0.015808778,-0.07272372,-0.049384754,-0.030089112,0.054510463,-0.04671306,-0.07045826,-0.015761541,-0.009821833,-0.006982688,0.009823032,0.062290497,0.0026773415,0.012010429,-0.115538195,0.041556314,-0.06818031,-0.013446165,-0.005262217,0.010288266,-0.090342104,-0.038383957,0.018295383,-0.011763825,0.00057773106,-0.015653718,-0.040288713,0.032551568,-0.0039394847,0.0339974,-0.030005684,0.04708568,0.07655984,-0.047611166,-0.01500725,0.031871073,0.0060712625,0.09147817,0.060775053,0.0281561,-0.052497603,0.012292225,-0.104601644,-0.011997114,0.0018805313,0.013437041,0.03671302,0.0012015165,-0.061937217,-0.023396965,0.019916978,0.007027921,-0.08433834,-0.07146915,0.022314742,0.0004253465,0.080243185,0.10271382,0.004546108,0.058112774,0.05952362,0.076976955,-0.00813101,-0.097282834,0.02137147,-0.0020488761,-0.054091852,-0.063404284,0.034675043,0.042494286,-0.029197771,0.023353996,0.079669654,0.0019637563,0.045167528,-0.049006317,-3.2256745e-34,0.0452672,0.09954766,0.04480317,-0.02448485,-0.04037767,-0.010794954,-0.09847466,-0.00732386,-0.05452905,-0.004746583,-0.113507554,-0.08276065,-0.0040254015,0.09512207,0.026391666,0.038798187,0.063809544,-0.008413389,0.051655903,0.009951102,-0.023847936,-0.0025889312,0.006861878,-0.037423465,0.13098295,0.0512983,-0.003926195,0.021400545,-0.025882587,0.0067056934,0.060318492,-0.07882813,-0.08640192,0.028478457,0.080602065,-0.039070196,-0.058335487,-0.028276127,-0.003975186,0.077356435,0.008568264,0.060503464,0.024142854,0.016597927,-0.0024763895,0.04448908,0.023259062,0.030327387,0.07122319,0.09029137,-0.004920759,0.009615519,0.057248566,-0.04432238,-0.05013372,0.05069976,0.0109078875,-0.009772438,0.040082756,0.11945722,-0.016554274,0.056046467,-0.04392856,-0.0014047471,0.036215294,-0.009123194,0.02226054,0.014309341,-0.0010376938,0.003944362,-0.05423216,-0.012151747,0.09271361,0.037635826,-0.015569109,-0.02603506,0.032303017,-0.05547249,0.060882226,-0.06925909,-0.04817061,0.04803729,-0.040053006,-0.011120809,-0.032745622,0.014357327,-0.07239115,-0.04306239,0.013742072,0.037148826,0.030818269,-0.04078631,-0.05438584,0.05260987,-0.083038166,-2.6698162e-33,0.064512074,-0.15298045,0.041923217,-0.06021506,-0.07383916,0.011549937,0.01984516,0.020768207,0.0059394003,0.042494837,0.0436189,-0.014250405,0.0041108793,-0.0663064,-0.0053435196,0.019773433,0.04112379,0.08819892,-0.05865709,-0.030138856,0.0017204877,0.036719177,0.037855204,-0.02170603,-0.0019829737,-0.0047536306,-0.016255923,0.07702874,0.072968766,0.058989126,0.028272018,0.022306923,-0.051615212,-0.105000645,-0.036685538,0.07395564,-0.0067987125,0.01716916,0.04839655,-0.029352548,0.055825353,0.11694038,0.02335183,-0.0017009121,0.071119025,0.0107809035,-0.056385636,0.018417861,0.041710958,-0.060045827,-0.03308855,-0.061776236,0.034979187,0.002051995,-0.00044301842,0.02408741,0.032679837,0.013067104,-0.018489398,-0.0779433,-0.020741114,-0.062227134,0.071250446,0.015854636,-0.00673796,0.08749193,0.029971417,-0.008079866,0.058017906,-0.0009826649,-0.04206307,-0.080665454,-0.0019036458,0.04256941,-0.046277188,0.02329979,-0.041818757,-0.106467456,0.029897707,-0.033695333,-0.023146188,0.060715113,-0.055239398,-0.082865305,0.05906474,-0.010821325,0.047510155,0.13299605,0.028785752,0.050469503,-0.032405205,-0.043251783,0.0030410767,0.04486395,0.017560702,-4.1984208e-08,0.059596185,-0.083465345,0.082708694,-0.07781748,0.013718743,0.03713486,-0.017212352,-0.012925998,0.062482815,-0.046075914,-0.055955824,0.042766776,-0.029339265,-0.06934947,0.034718953,0.09077393,-0.08829001,0.029289635,-0.036788188,-0.014491202,-0.06513502,-0.0016328901,-0.13688318,0.043797564,-0.0030659093,-0.0606884,0.01397894,0.049865145,-0.07809701,0.0043799896,-0.023834975,0.041780163,-0.10326531,-0.0014913152,-0.041778184,-0.11225278,-0.050724227,-0.02074837,0.0643171,-0.03549779,0.04143939,0.019922113,-0.02488986,0.046581414,0.028407812,0.023936646,-0.05109455,-0.03516826,-0.030994356,0.038308386,0.053474244,-0.043838646,-0.022606203,-0.04518465,-0.05858559,-0.038589895,-0.0089102825,-0.0908913,-0.028487096,-0.03929006,0.0022001162,0.0016159045,0.14941217,-0.095664136 +3.5.1.108,A zinc protein. The enzyme catalyses a committed step in the biosynthesis of lipid A. ,384,1.0,-0.13611622,0.03747317,-0.08186175,0.03581214,9.93401e-05,0.039669707,-0.03407958,-0.007038171,0.010250949,-0.010562433,-0.009024926,-0.025962831,-0.0029151961,-0.043343365,0.004873114,0.007261897,-0.0680551,0.029846499,-0.06494582,-0.03113635,0.092546545,0.08200881,0.022928912,-0.00949357,0.02314212,-0.0016726156,0.041453235,-0.04650641,0.019130081,0.0060075643,-0.032799806,-0.036720205,0.056889687,-0.04760189,0.03953783,0.050427716,0.012849938,0.017480433,0.014280951,-0.020655444,0.09074393,0.05496722,-0.013353646,-0.034916118,0.008197375,0.027722374,0.019043274,0.04175931,-0.021715004,0.026351094,-0.1074407,-0.08392014,-0.053098384,-0.0051277406,-0.044361968,0.086175375,-0.055284932,-0.0042098057,-0.011877512,-0.019300275,0.016447162,-0.0998921,0.036071174,0.03477915,0.071437396,-0.09219079,-0.020644214,-0.0492805,0.0063046194,-0.074582554,-0.04952722,-0.051653188,-0.07117457,0.003693784,-0.041796185,0.023057327,0.037641708,-0.08509096,0.026830848,-0.033597082,0.0548165,-0.05022239,0.016239226,0.1408731,0.09055973,-0.0011309125,-0.018123342,0.02345689,0.0066866926,0.0976489,-0.0019334529,-0.017781325,0.064004935,0.07794048,-0.08785948,0.056464802,0.053440355,-0.032190647,0.026461909,0.014008062,0.038421232,0.041150205,0.033304248,-0.073034085,0.005948699,0.035070963,0.027890949,0.055068485,-0.107406996,0.05099908,0.04325149,-0.04189086,0.066202424,-0.0018135698,0.003897252,0.04545941,-0.013187633,-0.019972127,-0.061819702,-0.018438322,-0.031626362,0.0019196378,-0.002954573,0.068049565,-0.05377264,0.087946475,-0.09794403,-2.3035649e-33,0.0037017593,-0.0119239185,-0.0255041,0.011911875,-0.050284375,0.040637664,-0.030799298,0.031628676,-0.0123326015,0.023844123,-0.049391147,-0.15713334,0.05531434,0.010982221,-0.038996384,-0.056658715,0.050236955,0.058900725,0.06586184,0.04408999,-0.009959132,0.04436802,-0.030993825,-0.054009203,0.053813428,0.0020247037,-0.05909798,-0.08764702,-0.024286661,-0.03592805,0.0070912563,-0.06506564,-0.063892126,-0.026867941,0.18455097,-0.046003684,0.05507267,-0.030904736,-0.04634606,-0.06802816,-0.047445368,-0.017970745,-0.096825324,0.0139446845,-0.0035315799,-0.00029219865,-0.111939125,0.033524662,0.09415493,-0.04729943,0.04812815,0.058028504,0.120855965,0.013959496,-0.10371926,-0.020056289,-0.03717972,0.041264523,0.010301754,0.061098605,-0.033222266,0.101012446,-0.11145753,0.08812406,-0.0015691717,-0.018799786,-0.11259935,-0.036423467,-0.033156212,0.0826949,0.032288313,-0.0473425,0.05959192,0.00020528532,0.052488953,-0.040769875,-0.014904532,0.01814052,0.062145095,0.0042326804,-0.028176637,0.0017028801,-0.058128934,-0.030341797,-0.06665777,0.024133228,-0.053385813,-0.08418573,0.0432316,0.021654977,0.014028106,-0.006283611,-0.030864628,0.06259526,-0.012042824,-6.580051e-34,-0.0029940754,-0.008072933,0.0076468335,-0.05198975,-0.0118074855,0.014711246,0.0043541,-0.08997958,0.06493031,-0.03278045,0.008619456,-0.025992677,0.033694085,-0.0177853,0.015193112,0.054484732,-0.04735505,0.024274055,0.07254893,-0.026984181,-0.020966267,0.019456273,0.022722762,0.06872302,0.0045577106,0.032827787,-0.035211593,0.071355455,0.05081095,0.084669426,-0.010402907,0.006004533,-0.046190277,-0.03651543,-0.06433195,0.05768377,-0.017121473,-0.019680068,0.0215598,0.015837763,-0.029847361,-0.0055712606,0.0033302587,0.09005419,0.09765645,0.020638833,-0.048808165,0.055067968,-0.068422474,-0.03530505,0.0190474,0.062965415,0.031220824,0.052486524,0.044803344,0.078594156,0.055550802,0.009326254,0.0467538,-0.08017439,-0.0064423387,-0.070849925,0.004270073,0.044132955,0.023795806,0.06077969,0.025379261,0.041384134,0.022488052,-0.015216725,0.08102379,0.12573247,0.012131103,0.009751184,0.048595883,-0.0012327374,-0.022635622,-0.11327668,-0.06243959,-0.011058729,-0.0062754373,0.08136,0.058784448,-0.06709657,-0.025505649,-0.041332696,0.0406567,0.032707166,-0.049205706,0.040039282,-0.031184226,-0.089039646,-0.09123848,0.042918134,-0.033237223,-2.1734207e-08,0.005924302,-0.0297908,0.029209541,-0.090433374,-0.025384417,0.01676468,0.0485041,-0.060390018,0.0327386,-0.047626566,0.03344194,0.09022326,0.028897325,0.0447315,0.009127859,-0.008282921,-0.052618016,-0.010042982,-0.0404025,0.006318546,-0.00043557267,0.054689284,-0.11984135,0.036121782,0.0005988414,-0.090563394,-0.035391986,0.04451156,-0.0011661835,-0.02282853,0.0037576498,-0.010406138,0.04664484,-0.020927759,0.016605679,-0.01683604,0.022029573,-0.0900304,-0.016466403,0.022378415,-0.03650104,-0.016533624,-0.022350667,-0.008805902,-0.024928031,-0.06785808,-0.04508482,0.021677202,0.0056459387,0.062267363,-0.008026425,-0.02067675,-0.03989345,-0.055938747,0.019217545,-0.06890823,-0.028072927,-0.02614254,-0.047826562,0.015834548,0.0001274689,0.039538085,0.16792142,-0.058564715 +3.6.1.54,The enzyme catalyses a step in the biosynthesis of lipid A. 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+5.3.1.28,"In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein. ",384,1.0,-0.06232687,-0.047778167,-0.07562604,-0.034512963,-0.034820933,0.05081348,-0.036714315,0.077299416,-0.011010588,0.04746226,0.04906143,-0.0037221108,-0.051256366,0.038755745,-0.023961801,-0.047289565,0.021667685,0.032896567,-0.027844094,0.0013240038,0.08756044,0.019664293,-0.08312774,-0.078015015,0.058889333,-0.04778687,-0.0074446574,-0.043055814,0.024013655,-0.02367325,-0.012329176,-0.072677806,0.10689521,-0.059094302,0.07932113,0.082386434,0.017520167,-0.0013830541,0.10410933,-0.03837124,0.0013068267,-0.010300526,-0.040871404,-0.05035738,-0.014782876,0.03161154,0.008284596,0.0728238,0.03955208,-0.05551484,-0.01694973,0.007106329,-0.068291284,-0.022446198,-0.05146913,0.056560837,0.0067893923,-0.034075446,-0.037964977,-0.045006778,-0.011427264,-0.009168977,0.07364339,0.030639287,0.030732943,-0.12874956,0.09554947,-0.026915807,-0.0054278634,0.046251144,-0.010862953,-0.06506619,0.0070705926,0.01652149,-0.015541023,0.038951993,-0.023661241,-0.035130776,0.06732442,-0.08683415,0.117379226,0.005172229,0.0054959045,0.12171687,-0.051020503,-0.06623095,0.025380565,-0.017632615,0.053111255,0.049928345,-0.0066728913,-0.081797205,0.010060972,-0.08421542,-0.051200774,-0.031689927,0.0035980272,0.021913571,0.03879158,-0.07964231,-0.002364638,0.02886805,0.01640022,-0.08324342,-0.045504786,0.005865109,-0.082478404,0.05568792,0.07246085,-0.0009831229,0.0083078,0.07813023,0.060096566,-0.06870426,-0.08079771,0.0016510091,0.043257564,-0.05135861,-0.042698078,-0.026597133,-0.025363375,-0.030114213,0.028273944,0.058663562,-0.01421734,0.059764475,-0.008807246,-1.4566447e-33,0.039010707,-0.009952785,0.033366304,-0.07079829,-0.013815784,-0.052156933,-0.10743994,-0.0767628,-0.07286468,0.018684987,-0.039756045,-0.122603,-0.0041730036,0.08342442,-0.020523738,0.07524632,-0.013105026,-0.004071846,-0.011394354,0.018432133,-0.0498354,0.029500457,0.02361089,-0.025371892,0.11383904,0.05544499,0.005740204,-0.0075225863,-0.04282948,-0.004476494,0.015245426,-0.04986168,-0.07079005,0.038003586,0.12752008,-0.012380385,-0.041960903,-0.061567895,0.048638716,-0.007924959,0.0070537413,0.07910404,-0.00465034,-0.023937732,0.012785207,0.08090389,0.006280644,0.04890257,0.06488404,0.0520528,0.06966257,-0.03259577,0.03840633,-0.009335179,-0.021426123,0.07212214,-0.037429173,0.0027527264,0.048219357,0.05316657,-0.028256975,0.039109383,-0.08959829,-0.021151934,0.024003664,0.008115016,-0.018862648,-0.029576909,0.03363277,-0.006480483,-0.058053803,-0.044760402,0.038479574,0.07004297,-0.01996273,-0.00074954686,-0.0032250662,-0.011098718,0.017564287,-0.036767557,0.0032938134,0.04772107,-0.02107098,-0.10364919,-0.013072103,0.018173628,-0.0698885,-0.078329444,-0.025143666,0.03138253,0.0007985437,-0.017085815,-0.05227447,0.11353956,-0.05842698,-3.3156398e-33,0.032670006,-0.12314487,0.039053336,-0.046195265,-0.07209933,0.061406292,0.00906286,-0.004767855,0.025596093,0.0379912,0.012635752,0.01408679,0.008717524,0.029809466,-0.008349614,0.018771524,-0.024455192,0.0778196,-0.06327385,-0.034411848,0.012753734,0.046032522,0.040554486,0.032325074,0.061046094,-0.034116186,-0.09354943,0.15274759,-0.012893648,0.037304137,0.07861539,0.032926932,-0.055810828,-0.03763139,-0.06697564,-0.02693637,-0.040541712,0.04406129,0.040393263,-0.008144631,0.01897953,0.099315785,0.064934835,-0.020734033,0.010383637,0.015945401,-0.050674733,-0.00034094494,-0.004218328,-0.051935308,-0.054766726,-0.038306285,0.035996716,0.04660422,0.0095507605,0.071834296,0.014310807,0.026403287,-0.0048953085,-0.046667483,-0.058558356,-0.08433235,0.08451247,-0.035955854,0.036732834,0.098729804,0.06777463,-0.034988075,0.047655314,-0.05082324,-0.0005035142,0.016765863,0.00681228,0.0077233925,-0.00389847,0.00978653,-0.110314585,-0.0673398,0.034211826,-0.0455072,-0.013962718,0.05040298,-0.04842078,-0.012149666,-0.008969935,-0.026693182,0.016884478,0.13097188,0.02013844,0.040554214,-0.05363767,0.006356203,-0.0065014367,0.0094787935,0.05838201,-3.9557694e-08,0.06296528,-0.044192106,0.08709173,-0.0917602,-0.0086224275,0.0005682225,-0.026363656,-0.007429027,0.07082562,-0.02940574,-0.013208132,0.06423684,-0.057672884,-0.06776106,-0.038480382,0.04486135,-0.102120616,0.029577889,-0.044374436,-0.027604397,-0.041615695,-0.034566443,-0.11402619,0.12486938,0.033814337,-0.07743457,0.08258911,-0.013008162,-0.0474367,0.0011813459,-0.029771147,0.063627824,-0.06916261,-0.010107542,-0.05463401,-0.01682776,-0.06509212,-0.034399062,0.03347274,0.0028893985,0.052144587,0.033418637,-0.010634263,0.006288686,0.0017470259,0.068874285,-0.02940662,0.036666136,-0.07879289,0.03239232,0.016461393,-0.00049204536,-0.05947515,-0.0375046,-0.103974864,-0.02067599,-0.034320343,-0.051023494,0.0038456682,0.035563767,-0.015880486,0.00091838936,0.14283408,-0.061195903 +2.1.1.168,The enzyme catalyses the methylation of uridine2791 of mitochondrial 21S rRNA.,384,1.0,0.0026283516,0.01764419,-0.07968709,0.017399492,-0.03469956,0.049297582,-0.086486086,-0.048398342,0.005378311,0.008518337,0.06558544,-0.010963696,0.053507213,0.0098796785,-0.012544495,-0.010436317,-0.13143574,0.003386705,0.030402314,-0.02096472,0.07478533,0.07352984,-0.0024853158,-0.040129956,0.03129031,0.027909493,0.05225825,-0.035268024,0.017153554,-0.060375392,0.043838363,-0.009724172,-0.06019296,-0.004774392,0.02274015,0.057058137,-0.0537085,-0.018038169,-0.009072445,-0.010791206,0.0057822615,0.001176097,0.037120387,-0.013382502,-0.061923575,-0.0362277,0.061461046,-0.0036003343,-0.020032411,-0.004937895,-0.025083406,-0.049389534,0.009631672,0.03818365,0.09996294,0.04253705,-0.03159419,-0.07621852,-0.04064439,0.0028601266,0.050741807,-0.041043736,-0.052852433,-0.11426834,-0.056094095,-0.061403777,0.018447263,-0.03920427,0.02102875,-0.11318343,-0.04140405,-0.04502338,-0.053431123,0.026841588,-0.04192891,0.03404984,-0.005804288,-0.057300765,0.031882033,-0.013823437,0.0066904305,-0.05643904,0.043855987,0.012373343,0.11673086,0.0021702049,0.0756648,0.04246384,0.061428152,0.011260158,0.040090136,0.03242885,-0.023263233,0.020750055,-0.12108962,0.014251646,0.041992135,0.07351124,-0.015929012,0.0057086954,0.07230138,0.10407487,-0.07151517,-0.038306892,-0.012757611,0.014550442,0.049720254,0.14613734,-0.043469027,-0.022255572,0.05406769,0.056103833,0.04062185,0.070297785,-0.011730501,0.09728029,0.044349164,-0.02039162,-0.047222298,-0.0018606762,-0.043256886,0.026881555,0.02307473,-0.025327489,-0.025904637,-0.05637782,-0.0904118,1.5750936e-34,0.0043131635,0.06394363,-0.030298842,0.018637886,0.029224934,0.057623327,-0.0021338696,0.01073234,0.05453804,-0.12142853,-0.06976076,-0.06994564,-0.009944588,-0.04493833,-0.07715045,0.0021173086,-0.03223723,0.003451221,0.047326673,-0.0689395,-0.0041968394,0.045531172,-0.021152051,-0.12090312,-0.02311874,-0.008790355,0.042439137,-0.020448653,0.07899147,-0.014393293,-0.0005860843,-0.097276956,-0.09194804,0.05074706,0.015230124,0.017152358,-0.04587733,0.0033272307,-0.05243376,0.074761115,0.004420294,0.007446689,0.023387156,-0.048480224,0.007305839,-0.0085206125,0.038533237,0.09803416,-0.051146064,0.11782827,0.02342026,0.010618559,0.053492587,0.013462374,-0.10195686,-0.0006496534,-0.015463224,-0.03333404,-0.023918718,0.0131197525,0.048328348,-0.02468776,0.0539828,0.04477607,0.09152067,-0.04395269,-0.0005791781,-0.038361993,0.022358391,0.09303944,-0.02930594,-0.009085785,0.13737944,-0.089283705,-0.009321639,-0.021516416,-0.09845705,-0.027979296,0.059348043,0.012056689,-0.009991168,0.049669195,0.009991373,0.0064910674,-0.034899414,-0.0021414002,-0.018382696,-0.018838432,-0.029599274,0.014462677,0.03868806,-0.05741189,-0.058926057,0.003059812,0.021200603,-1.4208371e-34,0.094199486,-0.062677525,0.11297397,-0.07082263,0.02270266,-0.029120352,0.03750027,-0.006455808,-0.07133122,-0.09314684,0.0970408,0.0031024476,0.04238138,-0.04054683,0.024662958,-0.07726986,0.042206984,0.07176001,0.039944116,0.011847337,-0.04732019,0.06932366,-0.08407762,0.12108651,0.01537782,0.01820671,0.06273864,-0.025821084,0.13501441,0.015487298,0.05463834,0.03038923,0.0039058668,-0.052780908,-0.004796899,0.11407382,0.015837213,-0.009068777,0.024467506,0.016492762,-0.005897088,-0.054236908,-0.06946092,0.01472895,0.008133253,-0.006295134,-0.05256465,-0.012131689,-0.0041576843,-0.075669676,0.05938033,-0.00041655172,-0.0044922824,-0.0052986806,0.03839841,0.009215525,-0.04035865,0.005316842,0.07271612,-0.028203612,-0.02185717,0.021994058,-0.05469583,-0.010848475,-0.039321564,0.023324175,-0.0795629,-0.015536061,0.041720074,0.014311457,0.0093069235,-0.0146678705,-0.017897762,0.030929038,0.012103901,-0.11051455,0.0074085784,0.0005898053,-0.01150466,-0.08848071,0.018987369,-0.039325256,0.00942782,-0.058572467,0.00071465777,-0.09271897,0.06697623,0.0669676,-0.044398077,0.0063603744,-0.01026467,-0.030351821,-0.093474716,0.08544453,-0.009403602,-2.0490244e-08,0.008144697,-0.10577242,0.018284176,-0.0058893673,-0.04278806,0.12470561,2.9428322e-05,0.076950505,0.025993826,0.025336118,0.06870135,-0.027619353,0.02301949,0.06290951,-0.0048960084,0.062415987,-0.053725496,0.018424172,0.00033200608,-0.015223751,-0.033067405,0.012739934,-0.040302087,0.021484962,0.050812956,0.011772128,-0.027828421,0.095691346,-0.019745022,-0.08028584,0.09001634,-0.037212398,0.058910478,0.0135409525,-0.01969207,0.07616616,0.09068571,-0.03130654,0.031556427,-0.030450463,0.011059833,-0.017425152,-0.09072214,0.026064394,0.006985899,-0.04126174,-0.043401916,0.0758225,-0.019965952,0.028671533,0.012427385,0.007557136,0.04728326,-0.0867023,-0.033716787,0.030003477,-0.025563492,-0.06863986,-0.026827348,0.03102513,0.14330909,0.019558033,0.083460085,-0.04960377 +2.1.1.169,"The enzyme from Triticum aestivum catalyses the sequential O-methylation of tricetin via 3'-O-methyltricetin, 3',5'-O-methyltricetin to 3',4',5'-O-trimethyltricetin [2]. ",384,0.99999994,-0.026283842,-0.03518105,-0.08654704,-0.02668059,-0.020368412,0.07679229,-0.019074354,0.0068382425,0.026645023,-0.002831975,0.06274517,-0.064328864,-0.0810649,-0.060854096,-0.022738464,0.06025558,-0.07111777,0.021698011,0.013674644,-0.056982815,0.074152455,0.008349582,0.03593223,-0.053472675,-0.031406198,0.07088618,0.054333054,-0.018237902,0.049883552,-0.10790154,0.06776977,0.029387819,-0.036320712,-0.017827345,0.012484844,0.016332584,-0.04209877,-0.13021567,0.050731044,0.0755442,0.09788865,0.004279125,-0.06447363,-0.03919914,-0.022879899,-0.06838659,0.011069312,-0.014094479,-0.0077949585,0.026704218,0.011730259,-0.06318766,-0.07608382,0.00043205905,-0.014094713,0.039644487,0.0049227625,-0.010685433,-0.021478284,0.06617903,0.07700561,0.03466799,-0.044217117,0.0037371288,0.0016564701,0.0029909874,0.07718316,-0.06468719,-0.016170433,-0.013538377,-0.011171707,-0.041211177,-0.07917834,0.052319713,-0.05748485,0.013664332,0.06908141,-0.0071341996,-0.00914537,-0.07987272,0.0021660621,-0.014199218,0.07104573,0.06765926,-0.010319855,-0.013947895,-0.09363241,0.039747737,0.07350638,0.065303065,0.054852095,-0.015042033,0.029659957,-0.063718595,0.013838968,0.036814965,0.018410683,-0.011253292,-0.00749321,-0.020323878,-0.011676439,0.04871854,-0.08209752,-0.06182577,0.005284517,0.05207707,0.03009754,0.01946021,0.099437475,-0.0025054056,-0.06044686,-0.0061002728,0.07811971,-0.009650921,-0.1181665,0.083483644,-0.011650758,-0.046846434,0.04320108,0.010459699,0.026264599,-0.04333671,0.018499432,0.0720598,-0.05819502,-0.033225354,-0.07524987,1.3379049e-33,0.077713825,0.038657133,0.022792583,-0.034247633,-0.01666856,0.054346673,0.04175348,-0.00030509694,-0.011445607,-0.108119726,-0.08295188,-0.09652458,0.010856108,0.045094933,-0.029856643,-0.058571626,0.016994832,-0.013295282,-0.017697724,-0.049822636,-0.015597654,0.025808124,-0.06766612,0.016182248,0.007499821,0.07204301,0.020845026,0.041554533,0.08451734,-0.017540798,-0.010697447,-0.070967376,0.001467002,0.0304082,0.11721285,0.06878821,0.016841007,0.024243303,0.031470716,0.122547895,0.0102072265,-0.04819274,0.01718686,-0.005823484,-0.015005447,-0.028288247,-0.11265994,0.05305589,0.05538958,0.023501957,0.03004486,0.015908888,0.02786035,0.057257786,-0.12586226,0.0051752217,-0.054227468,-0.032356005,0.019496135,-0.032613736,0.021441909,-0.005798471,0.015578516,0.015653351,-0.025986305,0.027511634,-0.048567098,-0.098384686,0.043784592,0.06384674,-0.08155836,0.009937398,0.06483131,-0.013188468,0.10095331,0.010347273,-0.09097484,-0.006503117,0.022491142,-0.016635858,0.040055126,0.01836144,0.09766175,-0.049227133,-0.012116166,-0.006502136,-0.017095642,0.037549462,-0.019408064,0.029487725,0.041309666,-0.021071166,0.01707393,-0.025515335,-0.044907607,-1.1309282e-33,-0.016127085,-0.014743863,-0.015698958,-0.046772357,-0.014398718,0.04587003,0.0009649997,-0.032524906,-0.11256637,-0.047318164,0.095809065,0.015256912,0.06598191,-0.053597376,0.07167331,0.046400834,0.050785165,0.07079493,-0.003456395,-0.034843985,0.07220512,-0.059352126,-0.0425436,0.053630687,0.028642053,0.027912632,0.020282732,-0.019782681,0.076984085,0.059254143,-0.04870283,-0.05949866,-0.006150019,-0.028941153,0.02072457,0.10817831,0.038839582,0.045647144,-0.118949965,-0.010627137,-0.06408775,-0.08327506,-0.0056592477,0.06977216,-0.002950987,0.03413352,-0.09524402,-0.033909243,-0.080795884,0.031812746,0.07883767,0.007249503,-0.0010643837,0.049358517,0.03321454,0.025670586,0.033465594,-0.053040225,0.0029607601,-0.049739163,0.001067839,-0.02372372,0.07733267,-0.038722303,0.05869683,0.10802657,0.035818927,0.07768067,-0.03270661,-0.05739357,0.004576703,0.04161841,0.0020136547,0.037664954,-0.024043705,-0.08851186,-0.011500608,-0.021412289,-0.03086794,-0.050062705,-0.01834037,-0.020506984,-0.021321459,-0.07847169,-0.078329764,-0.022330105,0.08384356,0.11350854,-0.03199266,0.026073668,-0.051063474,-0.015205136,-0.049820375,0.031287756,0.05934731,-3.756312e-08,-0.01409875,-0.14101344,0.008555312,0.02844094,0.04516088,0.08010811,0.012122238,-0.015657863,0.011063877,-0.08213989,0.029903762,0.027794575,-0.00020359762,0.06519436,0.057502896,-0.01181109,-0.0010035618,0.047475122,0.031736664,-0.032664627,-0.050820753,0.06360061,-0.04996904,-0.007816954,0.06179225,-0.0013701199,-0.03619278,0.1170206,0.046286464,0.024049133,0.013170611,0.028387925,-0.013495751,-0.009815515,-0.106675886,-0.017920984,0.0052120183,-0.0041061426,-0.011574435,-0.016111227,-0.02701082,0.08979038,0.015157321,0.06328666,0.0450105,-0.08348651,0.06716626,0.009799484,0.058667522,-0.036847442,-0.0049033705,0.005220322,-0.0029742618,-0.05767958,-0.09228136,-0.1042201,-0.0013715953,-0.07805693,-0.06842852,-0.014412708,0.011254727,-0.029299062,0.1278061,0.036986243 +2.1.1.170,The enzyme specifically methylates guanine527 at N7 in 16S rRNA.,384,0.99999994,-0.05078364,-0.053034488,-0.12553915,-0.026772872,0.0040790862,0.017324943,-0.053747363,0.0064146454,-0.053688336,-0.040166833,0.026779594,-0.035287295,-0.053156655,0.07579492,-0.06066469,0.05493951,-0.049075488,-0.025765456,0.048367444,-0.0035574944,0.013979156,0.05298974,-0.02824038,-0.0073209163,0.016074076,0.03257707,0.053191967,-0.028686687,-0.00410768,-0.05285979,0.014749697,0.04863722,0.03226725,0.036454875,0.03816484,0.0800997,-0.0704719,-0.021326914,0.011779011,0.024033394,0.05867556,0.067794904,0.0455103,-0.0153826075,-0.00090193126,0.017432807,0.019401114,-0.025223905,0.020507568,-0.017587813,-0.035744384,-0.091670945,-0.012700761,0.04496319,0.08157536,-0.013439928,-0.08486808,-0.09448102,-0.06519491,0.038661856,0.07758773,-0.08439026,0.020881046,-0.056889053,0.013692284,-0.00021687594,0.07540298,-0.020213582,-0.0054748943,-0.06495252,-0.009568351,-0.018218795,-0.047149003,0.035541892,-0.07017969,0.05726358,0.04835526,-0.059979588,0.046292115,-0.039255098,-0.03203426,0.020855153,0.047862276,-0.020022137,0.12814613,0.03776621,0.032574706,0.07696514,0.040995207,0.054477103,0.08714727,0.037060488,-0.015018622,-0.035751905,-0.08063411,0.0052978024,0.012180022,-0.006996608,0.010046674,-0.031226425,0.04310805,0.09266447,-0.05949209,-0.017889533,-0.07518814,0.017377881,0.054209843,0.06482347,-0.04440349,0.013463525,-0.0105953105,0.11032574,0.04435001,0.015346387,-0.008857379,0.04312072,0.029042566,0.008232174,-0.030916877,0.03774177,-0.06950055,0.026089469,0.02069663,-0.0045863544,-0.051004276,0.014941491,-0.10846176,2.0268358e-33,0.036749143,-0.0015820136,-0.00572768,-0.014220824,0.049961213,0.055859763,-0.070001386,0.022010181,0.006452297,-0.07713507,-0.10290446,-0.10016757,0.03694131,-0.022019008,-0.08455788,0.069431104,-0.005378828,-0.035838127,-0.0121221,-0.10943056,-0.0055390378,0.023438467,-0.04157477,0.00092678505,-0.008328891,0.05438834,0.023396375,-0.013792203,0.09199121,-0.040654335,-0.07605196,-0.10080867,-0.05926093,0.04576075,0.07250798,0.04840717,0.0023356136,0.0028278623,0.008082634,0.0853842,0.038202636,0.03196262,-0.011638659,0.0063478476,-0.02586249,0.00225902,-0.051070016,0.07837379,0.0411104,0.034898877,0.037010264,0.0034232312,-0.0037909122,-0.018872796,-0.068132535,-0.017407008,-0.046897322,-0.0411823,0.011358209,-0.017666975,0.014168979,-0.051780898,0.018200884,-0.00983482,0.008781906,0.020830426,-0.1019626,-0.08733837,0.018950477,0.06951427,0.019954605,-0.06987345,0.14996722,-0.02430488,0.045017835,-0.03372919,-0.08397258,-0.06888484,0.051204488,0.083452284,-0.034523465,0.03563947,-0.006499419,-0.008337231,-0.09485972,-0.03204809,0.048341766,-0.06671886,0.055304658,0.045045312,0.034990095,-0.04223572,-0.014368629,-0.03713108,0.0025658703,-1.6445803e-33,0.07118539,-0.07185632,0.06729915,-0.022124568,-0.024525834,-9.072379e-05,0.01659367,-0.039261747,-0.03604405,-0.10070037,0.15404963,-0.011579395,0.061867084,0.02224618,0.045449466,0.025073405,-0.0065576904,0.108013205,0.0027347684,-0.028447839,-0.0245138,0.011757466,-0.050439138,0.059546184,0.05213312,0.038838036,0.017226992,-0.009356009,0.08374927,0.019544862,-0.06418924,-0.0068780584,-0.052756816,0.0053009433,-0.006537386,0.05384514,0.0062993397,0.0036399139,-0.057899874,-0.00011089956,-0.02714092,0.024606474,-0.016741412,0.12823121,-0.019585645,0.029951945,0.017362334,-0.020105869,-0.01755748,-0.025639571,0.040185377,-0.0016504757,-0.006352543,0.03706354,0.060610685,0.004387544,-0.034715075,-0.02140407,0.017494718,-0.039383188,0.006263381,-0.09465148,-0.07430541,-0.040942084,-0.0026496127,0.07172985,-0.008014437,0.04751775,0.022393303,-0.04590429,-0.01270515,0.0015324121,0.03260844,0.021986026,-0.05252253,-0.12106111,-0.030232802,-0.011567696,-0.0044312566,-0.12253156,0.008551775,-0.0021931685,-0.055460006,-0.04182022,-0.020419352,-0.03782975,0.10814807,0.08255181,0.014476989,0.0139601175,-0.055464517,-0.021255413,-0.09293346,0.07538658,0.05035973,-2.276728e-08,0.03738973,-0.09735821,0.007979416,-0.049698357,0.045746174,0.10567893,-0.037647538,0.046758235,0.06034996,0.01858733,0.044941515,0.027639186,0.0040478585,0.062032446,0.017022409,0.023794942,-0.026131256,0.004956244,0.018544639,-0.016023936,-0.057433415,0.06503851,-0.08875826,0.005208449,-0.044543184,0.00844848,-0.0053226803,0.14606793,-0.00890035,-0.09884755,0.062019184,-0.0069292537,0.115657076,-0.034486204,-0.04383912,0.055107296,0.079288945,0.0019744148,0.025650311,-0.0036895166,-0.008961099,-0.025771856,-0.06627574,0.03052908,-0.08363362,-0.0770712,-0.052734844,0.021147674,0.020110635,0.08688253,0.092465505,0.017658453,0.06655114,-0.0041069095,-0.027486581,-0.008400488,-0.011506241,-0.047427576,-0.07081531,-0.0020277766,0.04002999,-0.096145496,0.08260557,-0.064201616 +2.1.1.171,The enzyme efficiently methylates guanine966 of the assembled 30S subunits in vitro. Protein-free 16S rRNA is not a substrate for RsmD [1]. The enzyme specifically methylates guanine966 at N2 in 16S rRNA. ,384,1.0,-0.036945198,-0.07104308,-0.12202883,-0.06556303,0.043326728,0.028041545,-0.06918842,0.043085463,-0.03980809,0.0057254964,0.030586919,-0.0026187839,-0.046662502,0.10668313,0.017055215,0.054456502,-0.08851686,0.015300336,0.035790585,-0.009213673,0.012733657,0.010756815,-0.050322905,-0.025603991,0.041726336,0.028759388,0.07944667,-0.06542174,0.031030755,-0.008030429,0.057197534,0.012502892,0.01765666,0.0055299853,-0.008107091,0.08378341,-0.069164045,-0.043391738,-0.020824011,-0.0037875809,0.06148688,0.06739304,-0.036688093,-0.06333856,-0.004928938,-0.016803594,0.035717197,0.0072230888,0.014827385,-0.043910682,-0.024488892,-0.08481176,-0.040185187,0.050579235,0.05865792,-0.026006982,-0.09853265,-0.06703495,-0.077770464,-0.0032791062,0.058042683,-0.056264482,-0.013101831,-0.07197028,0.039971624,-0.0041283504,0.030759165,0.005118048,0.024388228,-0.022586739,-0.020254945,-0.02547016,-0.029665835,0.06653262,-0.077298895,0.06300316,0.072870314,-0.0464112,0.03938195,-0.04135584,-0.020667503,-0.0072037946,0.03685242,0.015816709,0.06904943,0.07482576,0.09615565,0.049547344,0.04280717,0.06607989,0.09137095,0.020712748,-0.015983185,-0.05835492,-0.06885669,-0.007574189,0.008881793,-0.0076143993,0.0015723486,-0.042824116,0.061730724,0.11834349,-0.056832734,-0.036317706,-0.074505456,0.010290653,0.033033606,0.029405711,-0.07087479,0.0344522,0.04327927,0.13456005,0.037955146,0.0014082148,-0.033496372,0.02808338,0.0039048917,-0.051565092,-0.071043506,0.052275103,-0.053520773,0.026352791,0.011942586,0.018103482,-0.027980838,-0.0053008213,-0.10580477,3.9037514e-33,-0.0022660145,0.05366786,-0.017163021,-0.053686347,0.046428256,0.04440933,-0.056791395,0.039475728,-0.014385101,-0.04364628,-0.08995857,-0.09788847,0.038898118,-0.027233785,-0.046569653,-0.0077605364,0.0027557542,0.019291727,0.022182401,-0.09077709,-0.06269348,0.051165152,-0.039690927,-0.024347793,-0.028145656,-0.014629064,0.015284193,-0.023519674,0.07257944,-0.027529301,-0.086934395,-0.056763005,-0.11077811,0.05461877,0.055622492,0.024613451,0.025180286,-0.02174374,0.016411979,0.03379816,0.1072695,0.0036380864,-0.00053485436,0.033154722,-0.021736873,-0.045121804,-0.058146,0.02813374,0.04942751,0.02259857,0.013175074,0.03209504,0.00943087,-0.0263133,-0.07557759,-0.03209379,-0.06012385,-0.052125778,0.03545551,0.014037331,-0.0061650663,-0.039299197,-0.009659409,0.03501309,-0.006203636,-0.015918674,-0.08484579,-0.10115169,0.021921756,0.0888777,-0.013066419,-0.058252092,0.1295568,-0.020900644,0.017788555,-0.03684741,-0.024630614,-0.0029083798,0.061259396,0.083269954,-0.032396566,0.06412079,-0.055436544,-0.017812679,-0.03510578,-0.06159243,0.044304203,-0.0659631,0.029177457,0.03672777,0.06493346,-0.08056876,-0.014364668,0.00022412252,-0.030616177,-3.8896436e-33,0.07294547,-0.08145697,0.06082543,-0.07311127,-0.028902976,0.012457996,0.043003652,-0.030293543,-0.023187041,-0.09006437,0.12644473,-0.013253741,0.040928222,-0.030270044,0.064413406,-0.0008081966,0.00044333684,0.11593442,-0.010230216,-0.023252478,-0.006903442,0.0496921,-0.0065471227,0.09001931,0.025287827,0.040417604,0.03282649,0.03346527,0.05592174,0.05417883,-0.01337982,-0.0034525492,-0.07239927,0.007851538,-0.03409676,0.048540223,0.01615362,0.024246447,0.021320662,0.002790162,0.0133570805,0.0749369,-0.057086542,0.1326353,-0.019290445,0.022342796,-0.009590384,-0.0010281696,-0.024519121,-0.06752548,0.04453737,-0.027304566,-0.008393769,0.0032659732,0.06493211,-0.026578315,-0.060230594,-0.011316679,0.039040565,-0.04324283,-2.6446167e-05,-0.06744526,-0.0768789,-0.037989378,0.013331527,0.064679615,0.05445662,0.011556492,0.02394966,-0.0400725,0.02111951,0.04239273,0.04652307,0.015191071,-0.015073082,-0.06391146,-0.054010034,0.002117417,0.00023853022,-0.13487054,0.0488035,0.029876782,-0.05942158,-0.055083036,-0.012854776,-0.024003938,0.08642157,0.10445759,0.015307527,0.0060346276,-0.022937177,-0.031900093,-0.020225948,0.14100116,0.12167677,-3.317341e-08,0.045001123,-0.11396039,0.0014653193,-0.027051866,-0.03170408,0.08669342,-0.061088145,0.010118533,0.032852676,0.013820005,0.059484523,-0.010279643,-0.057684537,0.068950765,0.025965879,-0.008518555,-0.061664995,0.059169088,-0.019549202,-0.05255786,-0.052486025,0.09907566,-0.05717265,0.023406576,-0.011113973,0.037475593,-0.030763408,0.085129224,-0.014638362,-0.09083942,0.07724649,-0.0013454357,0.050496235,0.033772275,-0.03759559,0.016585054,0.060233496,0.025049247,0.035677895,-0.003133785,-0.00054848247,-0.039034147,-0.06274548,0.015191918,-0.0622079,-0.03394696,-0.08492563,0.05624398,-0.022709293,0.053577136,0.083753884,0.027238976,0.03480968,-0.044322778,-0.05338979,-0.025304582,-0.061169267,-0.056966662,-0.049772784,-0.013376048,0.04243445,-0.023922635,0.07508905,-0.093211606 +2.1.1.172,The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA [1]. The enzyme specifically methylates guanine1207 at N2 in 16S rRNA. ,384,1.0000001,-0.030403284,-0.06661549,-0.09583825,-0.029390603,0.035449572,0.045337036,-0.039739713,-0.013696696,-0.023350645,0.017679984,0.025145927,-0.010529778,-0.06678054,0.021728504,-0.025478154,0.079304576,-0.10473944,-0.0405785,0.021180814,-0.02073766,0.028139664,0.028216684,-0.036830924,-0.01599834,0.003281847,0.019301178,0.05865127,-0.059807863,0.013699264,-0.054232247,0.014165351,-0.0096374545,0.046892103,0.053723186,-0.013115571,0.0835855,-0.07029631,-0.07496591,-0.015926294,0.059690546,0.038913682,0.03795403,-0.025746137,-0.048955206,-0.0052789506,0.024898726,0.041298233,0.01274145,0.005888614,-0.012343758,-0.0052423677,-0.064178735,-0.008303402,0.011916584,0.06700423,0.036773775,-0.056772366,-0.03764292,-0.024066972,-0.016896866,0.093247406,-0.07873672,0.0031864776,-0.039901957,0.033074394,-0.039158445,0.029242618,0.02425188,0.028478568,-0.04809939,-0.012912153,-0.009690514,-0.05374193,0.0420054,-0.07938474,0.02504311,0.06842888,-0.034778338,0.08897624,-0.016978683,-0.040156137,-0.05433098,0.06885651,-0.014758625,0.048403364,0.053816933,0.052459225,0.07999353,0.053490162,0.063744955,0.05640669,0.017656315,0.00743915,-0.029564405,-0.04177273,0.0293262,0.030974228,0.016358549,-0.029233413,-0.040978197,0.044365272,0.10100331,-0.041535646,-0.046203796,-0.08345384,0.017252019,0.08385759,0.011222895,-0.061075613,0.074014306,-0.007898773,0.070002735,0.051451575,0.015427374,0.001777601,0.045706313,0.029938161,-0.045228854,-0.047830738,0.032698236,-0.016498812,0.003716664,0.014134018,0.02942614,-0.093061276,0.018307682,-0.09813777,4.6458586e-33,0.028020352,0.01251084,-0.06524003,0.009314659,0.079240136,0.027948877,-0.041103296,0.04325818,-0.06382325,-0.05756458,-0.102938905,-0.09947413,0.03656056,0.0033591972,-0.09944887,-0.01226074,0.013755526,-0.014662347,0.0033947295,-0.10024457,-0.0243747,0.05199979,-0.05190402,-0.0009355846,-0.020028064,-0.012470501,0.008113542,-0.025543656,0.04641482,-0.04410014,-0.069955654,-0.06478809,-0.088937946,0.040274106,0.09295549,-0.019388404,-0.000961533,0.03301062,0.016046168,0.04515755,0.053966824,0.013817267,-0.0010802926,0.0050568525,0.015429308,-0.043520804,-0.04079927,0.04887871,0.04449416,0.030943783,0.07568742,-0.005730705,-0.027584001,-0.02074697,-0.06526022,-0.0044028084,-0.05018168,-0.0548664,0.010710137,0.020753883,-0.012355384,-0.024203844,0.041604936,0.0275233,0.020927696,0.0344027,-0.12181088,-0.090171725,0.0063444627,0.117890425,-0.0061586993,-0.03913241,0.11604032,-0.042924426,-0.0073189843,-0.036401965,-0.064037345,-0.07269053,0.0077044475,0.12299096,-0.029148478,-0.0011850178,-0.044928126,-0.0002880748,-0.052013885,-0.068994924,0.014249413,-0.10368977,0.03898971,0.06013476,0.03775749,-0.079843126,-0.033888094,-0.020267183,0.06845593,-4.919986e-33,0.070220426,-0.042072546,0.071604386,-0.034029152,-0.07137822,0.023991281,0.03442177,-0.0073032444,-0.022758478,-0.058788165,0.10117014,0.012733492,0.06758999,0.010675969,0.031031065,0.008003473,-0.017009988,0.1317216,-0.030113416,-0.031765793,0.019466344,0.03360071,-0.06792385,0.04525986,0.025229584,0.03856436,-0.004653137,0.029770544,0.022690032,0.038471837,-0.05267904,-0.04850403,-0.037842393,0.024941918,0.009703809,0.022062067,0.017948922,0.020305095,-0.009431557,-0.019097708,0.0012375984,0.04589913,-0.047322847,0.14832167,0.017327229,0.023930876,-0.0013998228,-0.025275577,-0.044466257,-0.050891295,0.038250532,-0.03452227,0.017428603,0.075361505,0.06595738,-0.044599842,-0.07504492,-0.0065972693,-0.022646194,-0.0288181,-0.021793386,-0.08412537,-0.061624832,-0.03291247,0.0593458,0.045001127,-0.021349607,0.06888035,0.02837276,-0.06008173,0.04813259,-0.004378646,0.0010645067,-0.012148807,-0.008498585,-0.09239146,-0.06778626,-0.017790742,-0.0027178545,-0.12852906,-0.012147626,0.016610747,-0.047151644,-0.062125534,0.023804478,-0.039639737,0.11053419,0.09721914,0.006653675,0.08586152,-0.021474546,0.00027981805,-0.01954497,0.09455794,0.06502596,-3.4564984e-08,-0.02534016,-0.052473478,0.009786654,-0.009021834,0.02693078,0.116306774,-0.066515714,0.04429027,0.040719233,-0.0037042696,0.057106003,-0.0029519072,-0.053502504,0.058384284,0.08044419,0.02635544,-0.060037624,0.022988984,-0.015027118,-0.0045909854,-0.046127286,0.11508284,-0.1025287,0.02817045,-0.08575497,0.0071308888,0.0067108716,0.10131782,-0.047814846,-0.09642767,0.04321297,0.027497219,0.049122985,-0.0557634,-0.074745834,0.048625506,0.09881647,-0.0065348307,0.036890034,-0.023654552,-0.0049867304,0.002109767,-0.06515966,-0.020616833,-0.09146677,-0.05251085,-0.06798195,-0.00533192,-0.0009912484,0.06606956,0.08806618,0.04433166,0.057825536,0.009847868,-0.028737362,-0.028641403,-0.058991652,-0.05244827,-0.056507006,0.03657305,0.02876706,-0.049269572,0.13069135,-0.09060743 +2.1.1.173,"The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate [1]. The enzyme specifically methylates guanine2445 at N2 in 23S rRNA.",384,0.99999994,-0.013830694,-0.080165245,-0.091377094,-0.067452826,0.011160594,-0.0061765416,-0.049302757,0.015236008,-0.041293744,-0.034645017,0.040777463,-0.044894073,-0.023374172,0.05399914,-0.0143404985,-0.009569265,-0.11592614,-0.045335278,0.040545266,-0.01296822,0.047045887,0.038866166,-0.054457843,-0.019367816,-0.010867753,0.038887665,0.01913703,-0.060079876,0.044017952,-0.034919497,0.0111998925,0.027414033,-0.015175389,0.028344698,-0.031585254,0.055813618,-0.10844154,-0.0038370637,0.030895852,0.0025295939,0.061521646,0.045603573,-0.012264596,-0.009699386,-0.0150838625,-0.036652528,0.037312996,-0.045588523,-0.06343779,0.028527943,-0.035289183,-0.09785558,0.029412627,0.0056953738,0.06610452,0.011587184,-0.034294646,-0.016560433,-0.050458953,-0.01986825,0.115535066,-0.040586878,-0.014673934,-0.11148901,0.0018535578,-0.013142446,0.03741913,-0.05414414,0.019791545,-0.05945058,-0.034846734,-0.028893247,-0.054775536,0.042582422,-0.077430286,0.068259425,0.09664409,-0.04467186,-0.005280884,-0.004554318,-0.01647188,0.0012959457,0.05649168,0.0022394336,0.07153153,0.0112584345,0.068451166,0.08255049,0.07380782,0.02619547,0.02298398,0.04167332,-0.059369203,-0.01681714,-0.078836024,-0.019819148,0.004884239,0.019083044,0.004521238,-0.017199583,0.06876761,0.079422325,-0.046198074,-0.016368225,-0.116442285,0.019052861,0.0243788,0.025111524,-0.056777064,0.009150173,0.022845794,0.10577502,0.018930053,-0.0014975166,0.02592387,0.075119205,-0.0141459275,-0.018704053,-0.0092528835,0.026180763,-0.05524151,0.03882013,0.018417664,-0.016966801,-0.05396622,0.00037227455,-0.13485867,3.0519825e-33,-0.0350241,0.01764863,-0.047262255,0.01691652,0.056398004,0.082640804,-0.0399804,0.052460797,0.0039001522,-0.072779395,-0.084032536,-0.110172436,0.030186139,0.0036785072,-0.05672386,0.025716556,-0.007171417,-0.019960355,0.0055948677,-0.07867569,-0.027557109,0.019213103,-0.098525465,-0.07946619,-0.01204314,-0.029930247,0.041570265,-0.023278825,0.09198744,-0.020545695,-0.06779621,-0.100727245,-0.054162007,0.05019239,0.095777065,0.024109064,0.0020363997,0.0456223,0.005889176,0.04465662,0.1091389,0.04195346,0.04470381,-0.01142567,0.022639217,-0.014743787,-0.0033797917,0.09567544,0.014271576,0.04355664,0.0018389667,0.0067294063,0.017471004,-0.012848511,-0.059885304,0.028612694,-0.039737623,-0.02918438,-0.030407595,0.010088311,0.01156549,-0.045269933,0.040237747,0.048004244,0.012361858,0.047806002,-0.08300306,-0.07574797,0.071048066,0.095122986,-0.040956803,-0.034996137,0.13428237,-0.061565455,0.016066045,-0.068633184,-0.057378963,-0.0013214067,0.07529737,0.056021675,-0.03514426,0.04043378,-0.025079528,-0.056678854,-0.057367656,-0.029847115,0.03049464,-0.04235566,0.021280793,0.07864275,0.03946974,-0.09475921,-0.02626223,-0.02142898,-0.00414724,-3.878086e-33,0.055523258,-0.039884448,0.05468567,-0.098373786,-0.024235928,0.00959471,0.030444743,-0.02446322,-0.053656686,-0.09158037,0.12469617,0.029700177,0.028061364,-0.0060142963,0.02308187,-0.0051856716,0.00085870386,0.100840844,0.03618742,-0.020004159,-0.0171175,0.01755736,-0.007919189,0.08259138,0.043422215,0.058598395,0.05877758,0.023383133,0.11258417,0.022765262,-0.058800515,0.026086701,-0.019657409,-0.015327493,-0.00090347015,0.06950455,0.03553872,-0.01607582,-0.015424782,-0.024849677,-0.016191686,0.044132415,-0.03930801,0.15292558,-0.045637038,0.050208125,0.009621481,-0.05201147,-0.048592467,-0.07223694,0.009950505,-0.04604655,-0.021289598,0.010997363,0.028503496,0.004600562,-0.02907923,0.022576971,0.030630024,-0.039372362,0.0092596905,-0.04602948,-0.060188383,-0.030260112,0.0036170408,0.029330414,-0.024114283,0.03769004,0.064976655,-0.011817573,-0.02950069,0.014195197,0.010154059,-0.01952322,-0.05794363,-0.08515349,-0.045435123,0.0038199234,0.009307778,-0.15032414,0.052468706,0.007598715,-0.04514232,-0.055705104,0.01363785,-0.069426805,0.058954537,0.120652206,-0.005037456,0.04946841,-0.030390656,-0.0022999446,-0.044984475,0.08738657,0.09228797,-3.0818654e-08,0.029664991,-0.082192816,-0.040443264,-0.017950494,-0.068106726,0.10712276,-0.054569695,0.03232764,0.024378313,0.045101773,-0.036240548,-0.0022213003,-0.03643643,0.1056581,0.0027679696,0.02014325,-0.081193306,0.04245934,-0.00010297297,-0.023081038,-0.07775013,0.06729216,-0.07387917,0.0351583,-0.021550797,0.03677628,-0.034008704,0.091458075,0.0054797824,-0.06129617,0.04791977,0.023903275,0.06714079,0.0058035073,0.0045943465,0.045832466,0.06002645,-0.012840739,0.01617039,-0.054824974,0.007514571,-0.05048181,-0.07506647,0.02382722,-0.008029956,-0.068998925,-0.08367759,0.09800782,0.0064704833,0.010271795,0.043215882,0.03648032,0.034870952,-0.0070210104,-0.020606566,-0.016147997,-0.036844943,-0.07302982,-0.056995604,0.04569438,0.03734098,-0.004278737,0.112906344,-0.107125096 +2.1.1.174,"The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate [1]. The enzyme specifically methylates guanine1835 at N2 in 23S rRNA. ",384,1.0,-0.010226008,-0.07513046,-0.09614747,-0.07032512,0.010622996,-0.006436027,-0.05411853,0.010626222,-0.043929406,-0.03597968,0.041314814,-0.051129628,-0.027004922,0.056908052,-0.011829157,-0.0047363597,-0.11212607,-0.04760138,0.044740427,-0.00813954,0.048457675,0.037776005,-0.057218812,-0.016903767,-0.013507464,0.03658302,0.019977711,-0.05350232,0.039411843,-0.030299207,0.006110839,0.029563736,-0.008212649,0.02389824,-0.025317712,0.060248155,-0.10765723,-0.0038118914,0.029493732,0.0062741796,0.063194625,0.04736199,-0.012129375,-0.016251277,-0.020552902,-0.03977596,0.04088319,-0.04144006,-0.057200104,0.020353626,-0.039921954,-0.09844657,0.031272464,0.009036816,0.06344227,0.010444357,-0.034743782,-0.02294437,-0.050481997,-0.026738703,0.109763294,-0.03952096,-0.014902236,-0.109470755,0.003470573,-0.0152739305,0.04019427,-0.06179252,0.014429654,-0.05872119,-0.03728695,-0.032167763,-0.062283605,0.04551275,-0.07187304,0.067118846,0.09917376,-0.039723374,-0.00023396632,-0.012365927,-0.018435763,0.0014503875,0.05903522,0.002077915,0.063460395,0.015501631,0.064875595,0.08564112,0.07192447,0.030942973,0.0251636,0.039634045,-0.05471409,-0.018916762,-0.07569341,-0.01575854,0.004615789,0.019557273,0.00672012,-0.01971334,0.06650261,0.07640566,-0.051001284,-0.015134056,-0.11505552,0.018381463,0.019158194,0.02658617,-0.05587268,0.01129246,0.02485612,0.107409574,0.022339331,-0.0046736314,0.017379533,0.073027186,-0.008954528,-0.014519984,-0.008611737,0.032032017,-0.04914764,0.038257807,0.024222406,-0.01058826,-0.048896708,-0.004860764,-0.13592559,3.0770253e-33,-0.030306306,0.017590987,-0.04594839,0.00717215,0.056254607,0.07326442,-0.044035643,0.04824497,0.0054208823,-0.08112826,-0.08802774,-0.10399136,0.03276539,0.0026185624,-0.04712764,0.025755852,-0.013046981,-0.013419527,0.0018212717,-0.079124935,-0.03370224,0.021659214,-0.09181347,-0.074715674,-0.014016376,-0.02599496,0.037360467,-0.020317242,0.085471354,-0.024588417,-0.066560835,-0.102837205,-0.062272824,0.047694847,0.09699061,0.03154926,0.0059203743,0.04313615,0.0022069248,0.05422945,0.10556382,0.04480648,0.045354676,-0.0073725646,0.020567896,-0.012798047,-0.014197702,0.091738395,0.020966182,0.03928389,0.0038396046,0.0045973537,0.014009499,-0.015461342,-0.066868074,0.02727893,-0.035138108,-0.02735931,-0.022928586,0.006947293,0.0060514,-0.044674616,0.04145336,0.049877282,0.0054774554,0.04460486,-0.08211414,-0.077782534,0.077667646,0.09218431,-0.044493172,-0.041309137,0.13625924,-0.05577359,0.021518592,-0.06654014,-0.05109665,-0.0013979467,0.076685116,0.056372494,-0.036683213,0.03917526,-0.023723882,-0.054422855,-0.056261934,-0.029663542,0.031834316,-0.045958452,0.020776693,0.075941905,0.041926388,-0.08820544,-0.023048533,-0.026245655,-0.0024610397,-4.021241e-33,0.05826802,-0.044643782,0.058338217,-0.09911968,-0.02966452,0.015891522,0.025160803,-0.022491368,-0.05663105,-0.10334662,0.123570584,0.02884138,0.031680062,-0.0022667581,0.024606407,-0.000111961825,0.0065588267,0.10518235,0.03398805,-0.019771118,-0.013496634,0.014837718,-0.0065099588,0.08045755,0.038329303,0.049108915,0.056801636,0.027292076,0.11629769,0.017505404,-0.05859883,0.026074704,-0.02738317,-0.014074556,-0.0008193865,0.0752091,0.029008782,-0.0134957535,-0.013479814,-0.016462583,-0.008702358,0.040473204,-0.04274838,0.15118805,-0.043287843,0.05027133,0.004607227,-0.04985328,-0.05036425,-0.06748465,0.0088035315,-0.044128224,-0.016440958,0.007481303,0.029741451,0.0076224566,-0.024332747,0.024175562,0.033546735,-0.04329771,0.006434236,-0.038501095,-0.061546188,-0.031041864,0.0034192167,0.034474514,-0.019846825,0.031126471,0.062860794,-0.0147865005,-0.022668669,0.016640618,0.014524151,-0.021741036,-0.05125499,-0.08484878,-0.050786648,0.0047671185,0.00978058,-0.15048702,0.057025805,0.016355047,-0.043246053,-0.055313233,0.015269515,-0.066273645,0.05999776,0.12373524,-0.0071314643,0.048108827,-0.02536056,-0.006876904,-0.044314124,0.08768853,0.09243323,-3.1378196e-08,0.032688316,-0.08279064,-0.04070867,-0.026980054,-0.06462771,0.109578215,-0.052912626,0.025995577,0.025780868,0.04159442,-0.03364162,-0.0014785881,-0.035579115,0.106664285,0.003911606,0.024716977,-0.077879675,0.041499354,-0.0008036035,-0.023243096,-0.08508507,0.07322269,-0.07667267,0.036343332,-0.02111887,0.039282843,-0.037503082,0.08831429,0.0031298874,-0.060094178,0.04926692,0.027324827,0.07094744,0.0069025857,0.004296527,0.041837323,0.058143236,-0.011669374,0.019103974,-0.05362948,0.010750795,-0.051604394,-0.07172057,0.021731626,-0.0086617535,-0.06624683,-0.089607514,0.10743436,0.0010648259,0.005690015,0.048323203,0.038571592,0.032975294,-0.013831261,-0.026451966,-0.018916165,-0.03943052,-0.078611575,-0.06240758,0.043077223,0.038622327,-0.00485699,0.11562832,-0.10776176 +2.4.2.43,"Integral membrane protein present in the inner membrane of certain Gram negative endobacteria. In strains that do not produce 3-deoxy-D-manno-octulosonic acid (Kdo), the enzyme adds a single arabinose unit to the 1-phosphate moiety of the tetra-acylated lipid A precursor, lipid IVA. In the presence of a Kdo disaccharide, the enzyme primarily adds an arabinose unit to the 4-phosphate of lipid A molecules. The Salmonella typhimurium enzyme can add arabinose units to both positions.",384,0.99999994,-0.011393712,-0.06980533,-0.056479815,-0.10091695,-0.07954639,0.021351794,0.018613867,0.030552188,0.042499088,0.01640863,0.081476785,-0.06852685,-0.07641996,0.038100526,0.009551922,-0.04163523,0.009091563,0.028273907,-0.07290816,-0.06374029,0.078601904,0.0059119537,-0.020820418,-0.079412185,-0.023009645,0.04671304,0.054229155,-0.01077841,-0.030578122,-0.052359164,-0.05405049,-0.07120263,0.097029924,-0.10707693,0.079546705,0.041482147,0.03510236,-0.013466051,0.116059,0.012371519,0.06257651,-0.012128209,-0.020616814,-0.0010902443,-0.02514091,-0.011127386,-0.049665313,0.061223883,0.11986716,-0.035348233,-0.036730856,-0.040183127,-0.023774799,0.022376446,-0.025059998,0.0010331343,-0.016102415,-0.0011074423,-0.04109498,-0.009504182,0.018377088,-0.015713718,0.11596567,0.0122821955,0.02472261,-0.124977626,0.049136292,-0.026601324,0.017572572,-0.022237636,0.00081962795,0.03552912,-0.0033750213,0.01909921,-0.028363952,0.040889096,0.019752346,-0.06309751,0.02347017,0.0048377262,0.0878816,-0.025554312,-0.011615497,0.07879796,-0.020644028,-0.08230005,0.013043698,-0.023504714,0.044658102,0.12197919,0.040152043,-0.02348736,0.03717585,-0.05500574,-0.015345351,-0.042656187,-0.012487537,-0.011339409,-0.03552102,-0.032520592,-0.049377263,-0.0392694,0.022200493,-0.06361017,0.035681546,0.002281706,-0.06305464,0.034765195,-0.008471709,-0.041888658,-0.0022287765,0.012246132,0.07802342,-0.03158713,-0.023241302,0.021278938,0.04842941,-0.05170269,-0.0013544011,-0.024625463,0.011579743,-0.08294502,0.008402548,0.04492967,-0.026541019,0.09257644,-0.033713203,1.7465137e-33,-0.0044683064,-0.042425435,-0.0016422794,-0.023885874,-0.012670865,-0.03980021,-0.08191664,-0.012557414,-0.09685041,0.0030737356,-0.08348169,-0.055459335,0.02998787,0.06259748,0.0146225775,0.08952276,-0.050216664,0.06856048,0.038807336,0.025785906,0.014768426,0.026318511,0.06319571,-0.060516283,0.09218762,0.05990198,-0.02314729,-0.10878747,0.00034731656,0.009488718,0.02562993,-0.058390666,-0.09751309,0.031810086,0.064782836,-0.008928366,-0.06411003,-0.009283594,-0.042815235,-0.04656102,-0.06494399,0.029991774,-0.025581364,-0.032227788,0.015394388,-0.05324292,-0.027782995,0.046461076,0.069362156,-0.02024205,0.05666994,0.021855738,0.029756285,-0.028691556,0.010120731,-0.03280642,0.021315098,0.059778847,0.023586182,0.012486985,0.019524412,0.07885095,-0.081719995,0.043487612,0.015341946,-0.003892926,-0.050299246,-0.05396378,0.0828714,0.0006326406,-0.026918551,-0.023300778,0.03416255,0.05031982,-0.037814613,-0.041824162,-0.029095879,-0.038790047,0.04898946,-0.015697934,0.07464822,0.0034820682,0.028354788,-0.07332926,-0.11051798,0.09107953,-0.019025788,-0.0031579982,-0.00013962098,-0.020047823,0.025154876,-0.019281548,-0.118216604,0.056508135,-0.008911058,-3.7755876e-33,0.03239388,-0.06460672,0.00526166,-0.10973056,-0.05435719,0.08608694,0.06963149,0.07930851,0.0707419,0.02277417,0.09874667,-0.020105906,0.013637555,0.00034750454,0.02133616,0.015456435,-0.045706976,0.0032402335,-0.034644388,-0.113221236,-0.043400858,0.024694722,0.056932483,0.070436954,0.013112636,-0.0033260584,-0.08231492,0.10925616,-0.060472615,0.035364337,0.03959197,0.0042346916,-0.028145608,0.028816627,0.002862322,-0.005512747,-0.0395922,0.006900498,0.08452658,0.055906437,-0.024105746,0.06124328,0.10274191,-0.022624347,-0.05716412,0.08493997,-0.019232046,0.010231608,0.004005341,-0.07026335,-0.0053636455,-0.038262904,0.011498304,0.018628227,0.050235745,0.07325214,-0.007664727,0.021444635,-0.024178633,-0.051138934,-0.040349778,-0.11065129,0.11356617,-0.046701618,-0.003971019,0.083400406,0.007793036,-0.01418704,0.0115748225,-0.066301346,0.024702141,0.08626566,-0.02826504,-0.004741099,0.009695825,-0.030814366,-0.12160212,-0.064785734,0.020525562,-0.035632186,-0.016177397,0.006326131,-0.05101834,0.016040498,0.10484545,-0.008786023,0.028198138,0.08795019,-0.0064768204,0.09774012,-0.019442515,-0.0031967747,-0.09592759,0.07219503,0.08546852,-3.9432827e-08,0.08793341,-0.0700262,0.024136005,-0.06438481,-0.029951924,0.027087087,-0.0029499636,0.016515054,0.056062832,-0.038522433,0.013721291,0.08275421,-0.01281564,0.0683007,-0.060303695,0.031654283,-0.08444539,-0.022799136,-0.009654651,-0.10866883,-0.0001689918,-0.027769117,-0.079810016,0.016525585,0.039084315,0.008850538,-0.006162967,-0.0147253275,0.00022872779,-0.015911268,-0.0053962856,-0.015402185,-0.045365196,0.019790115,-0.013868401,0.03755612,-0.07918921,-0.01393813,-0.07037695,0.037151303,0.07199804,-0.020709656,-0.09577972,0.0038716428,0.053798553,0.023556286,-0.0362987,0.059425995,-0.078723215,0.049932238,0.0754012,0.013719031,0.016330656,0.036629602,-0.07702522,-0.023138884,-0.05190297,-0.029929174,-0.0345603,0.07287927,0.012109247,0.019576004,0.1295718,-0.047011696 +2.7.8.29,This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.,384,0.99999994,-0.014109476,-0.02526092,-0.0924902,-0.0054943264,0.07068998,0.07553396,0.011242482,0.038505286,0.032895636,0.06864476,0.00250156,0.035760142,-0.1005872,0.049672473,0.04631005,0.061839376,-0.11138833,-0.022862947,0.0102553675,-0.022856366,0.06966492,-0.017049035,-0.039381105,0.026577616,-0.025718883,0.0449632,0.0075806817,-0.07263837,-0.018190527,-0.033866927,0.03508875,-0.050189454,-0.005435929,-0.03169312,-0.02355943,0.035201166,-0.049429506,-0.055522587,-0.009574288,0.005290878,0.052423038,0.029276233,-0.03715615,-0.067436,-0.052715197,0.018730132,-0.039956883,-0.003026908,0.052562516,-0.06987923,-0.010184277,-0.07718761,-0.060761683,0.020928858,-0.086054854,0.1001375,-0.103301354,-0.022917226,0.031342674,0.019360468,-0.061500408,0.089145035,0.027797004,0.034179755,0.09578377,-0.10341456,-0.00799329,-0.062236935,0.010927047,-0.005910969,-0.023239672,-0.066542156,-0.017532669,-0.032408174,0.010432557,-0.011603776,0.01643625,0.0307817,0.03195609,0.03776821,-0.013530752,-0.0048213815,-0.02233456,0.09864303,0.082400024,0.019529434,-0.051371027,0.019458562,0.05400556,0.03566044,-0.029338397,-0.05345846,0.018602487,0.0224636,-0.015036512,0.016434148,0.030121932,0.046920694,0.026970148,0.031926394,0.016614065,0.06869617,-0.086323075,-0.13501637,-0.042217884,-0.014807643,0.04987622,0.049119383,0.018297914,-0.016642343,-0.0073031234,-0.036256332,0.03127881,0.06460778,-0.029465128,0.0691379,-0.03338307,-0.040571373,-0.04348968,-0.03966262,0.050469805,0.008930693,-0.0029749954,0.04282725,-0.07951809,0.0846538,-0.119659215,-1.2284547e-34,0.022710875,0.041157953,0.04361735,-0.06499404,-0.04662749,0.0004719621,-0.01686235,-0.006222132,0.020440333,-0.08443515,-0.08758998,-0.009075831,0.04643334,0.05802032,-0.08045846,-0.07654657,-0.01794997,0.02980083,0.114538305,-0.01116964,-0.0025230956,0.008833334,0.0011962341,0.06645181,-0.0193617,0.071553946,-0.09177883,0.027835345,0.022748837,0.0380581,0.0046005305,-0.042282443,-0.12839626,0.017043523,-0.043760072,-0.013901677,-0.044753674,-0.12182196,0.019759487,0.03711051,-0.0047299447,-0.012731284,-0.06730472,0.04283517,0.009106689,-0.009770164,-0.08604597,0.0753818,0.036946997,0.029104926,-0.048733316,-0.038097683,0.07261844,-0.045181934,-0.05530314,0.017517049,-0.022255529,-0.031577185,0.00602451,0.03807143,0.005039845,0.08592943,0.006894481,-0.009600055,0.0765202,0.008724359,0.015080224,-0.041099373,-0.070853226,0.035173964,-0.02757518,0.002781858,0.043881837,-0.0002548807,0.03204753,-0.074976094,0.015228718,0.05091359,-0.01972544,0.007673656,0.060038615,0.025442373,0.0124760335,0.014095432,0.042874448,-0.05114935,0.044934135,-0.051409476,-0.04935775,0.05475783,0.0076807532,-0.09762427,0.016748918,0.058625113,0.011124923,-2.6941563e-33,0.0026828728,-0.09506326,0.004559826,-0.08191826,-0.081290446,0.049746018,0.073592186,-0.04333255,0.05492819,0.05360333,-0.007177749,-0.053505618,0.061115228,-0.027871279,0.0066596777,-0.038632102,0.010433046,0.057470262,0.036533076,-0.053843863,0.001164895,0.13487735,0.0022177729,0.08880132,0.11570528,-0.037393577,-0.036777083,0.04457089,-0.018785901,0.037173167,0.020083105,0.018988905,-0.0289483,-0.06416747,-0.024264287,0.089410685,-0.027874505,-0.021635884,0.06354818,0.045246344,-0.032747258,-0.0012545177,0.14343266,0.053733647,0.034222644,0.057409372,-0.087183714,-0.004450339,-0.051774222,0.0040877396,-0.021612681,0.060518067,-0.018758457,-0.0706961,0.0076211267,0.06105659,-0.008464681,0.023360105,-0.04534389,-0.10661371,-0.0015355058,-0.094035044,-0.03457394,0.06488589,0.005774739,-0.011339411,0.03359037,-0.05015158,0.058981773,0.006306344,0.09837944,0.03239114,0.021333242,0.006087491,0.012451405,-0.0020174521,-0.07196346,-0.014831441,0.011985105,-0.037775036,-0.02557152,0.029850699,0.07645983,-0.1002542,0.026704375,-0.058197096,-0.018650528,0.16124561,-0.036213316,-0.01095108,0.015979191,-0.09170042,-0.07584839,0.036104873,0.07042209,-2.730041e-08,0.07781133,-0.10749024,0.054686997,0.004401933,-0.033228397,0.05269424,0.00088558707,-0.01431724,-0.013830306,-0.03544498,-0.00039266222,0.060682174,0.05631035,0.011556596,0.037378706,0.048126776,-0.023273315,0.049942717,-0.011922516,-0.022130731,-0.021764982,-0.028792,-0.03634043,0.056232013,0.03183397,-0.06673695,0.042903144,0.076201715,-0.100062214,-0.054897532,-0.0057960553,0.023958076,-0.040400766,-0.03213376,-9.074714e-05,0.009970778,0.02400795,-0.018192165,0.014074877,-0.0016042327,-0.04547554,0.03155309,-0.029892676,0.021193078,-0.008800217,0.057276804,0.07217487,0.0074548908,-0.012393491,-0.056909297,0.026053343,-0.028416982,-0.066306286,-0.03831602,-0.07945538,0.012150139,-0.07018507,-0.05656466,0.0122633455,-0.07048696,0.006832322,0.07530424,0.14154749,-0.07868435 +3.1.7.6,The enzyme is involved in the biosynthesis of acyclic sesquiterpenoids 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+4.2.3.48,"The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [2]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.",384,1.0,-0.03318684,-0.047435503,-0.024273187,0.03385479,0.074799255,0.06929617,-0.008184371,0.043481503,0.10016694,-0.029160231,0.071804844,-0.095464885,-0.02671845,-0.020345956,-0.0009113375,-0.017474333,-0.039045922,-0.0067200246,-0.041159023,-0.038142018,0.04378831,0.0339125,-0.029874636,0.028007727,-0.03326837,0.023967959,0.011672602,0.007320115,0.024424227,-0.057126407,0.055753168,-0.010116306,0.026609492,-0.02254844,0.0030882286,-0.02726701,-0.0144144315,-0.0713594,0.06585831,0.07847341,0.012193026,-0.025593655,0.031004615,-0.049525656,-0.18403271,-0.086895846,-0.033410683,0.02044812,0.05952089,-0.07305199,-0.023832064,-0.012457303,-0.08272419,0.010872879,0.015944673,-0.07437239,0.092339404,0.04797261,-0.029714849,0.02341502,0.12929541,0.030250393,0.017630855,0.06262142,-0.123801276,-0.051426444,-0.0030042036,0.05646033,0.01656011,-0.0112879565,-0.051366523,-0.079402715,0.003669153,0.02573005,0.0053847698,0.021022229,0.005370529,-0.047190502,0.059834197,-0.09147168,0.0017322995,0.040058278,0.037186544,0.09876209,0.06378616,0.04265107,-0.018618973,0.016141046,0.09462096,0.049591172,0.060245812,-0.008155397,-0.042575363,-0.0004616105,-0.046646934,0.16151592,0.04215425,-0.07015813,-0.07003613,-0.034488186,0.012147263,0.048548046,-0.14523178,-0.061588425,-0.011759546,0.1031377,-0.020316668,-0.0616241,0.025861159,-0.011774947,-0.028682796,-0.03972112,0.04591425,0.018901229,-0.11579317,0.0589975,0.021440648,-0.049846258,-0.00978527,-0.085940175,0.023745129,-0.047552105,0.00067978207,-0.033824563,0.0013540256,-0.03317664,-0.021893911,1.012306e-33,0.002958056,0.03241253,-0.087467596,-0.02330312,-0.019122597,-0.09622065,-0.04565833,0.084748454,-0.09170481,-0.031262215,-0.08817325,-0.101695,-0.014004362,0.030360559,0.005773069,0.04274322,-0.00020437253,0.016236315,0.007664121,-0.07832225,-0.013539464,-0.03950036,-0.036038317,0.019515775,0.010099654,0.08114679,-0.006785471,-0.0044319546,0.04437804,-0.026298981,0.009718757,-0.0685036,0.006252727,0.017193615,0.09005016,-0.014372778,-0.049961437,-0.03666682,-0.04913706,0.055117134,-0.029460067,0.05828092,0.031418506,-0.0020017624,0.02404783,0.008750945,-0.08692748,0.059810955,0.10434786,0.058132384,0.030859733,-0.034358542,0.13929293,0.033113964,-0.042592116,0.10696399,-0.067569286,0.023668887,0.014919592,-0.061095353,-0.021958409,-0.009386374,-0.018778892,-0.04257822,0.049038887,0.06394021,-0.04029228,-0.048139334,0.048394557,0.032076504,-0.0603462,0.0026446073,-0.026279585,-0.03324725,0.10567964,-0.016543817,0.013421641,-0.029953642,0.043297336,0.035079163,-0.031101868,-0.07089055,0.05422484,0.0042077545,-0.06768159,-0.032220658,-0.018251546,0.028606897,0.0032446268,0.04959051,0.073850304,-0.09036415,-0.027153106,0.013694019,-0.051419362,-1.7381234e-33,0.013137422,-0.0043348004,0.061466478,-0.06743664,-0.059656344,0.05934079,-0.050981034,-0.028613934,-0.026362918,0.004529931,0.011902464,0.050999347,0.04507082,-0.071865365,0.0150953075,0.034246475,0.04505309,0.03779266,-0.0077712624,-0.06846832,0.01136892,0.02654573,-0.032201864,0.058539134,0.0070731146,-0.03255813,0.0527008,-0.027167715,-0.01310408,0.037827276,0.123450644,-0.04548587,-0.019829968,0.023801446,-0.016793966,0.065372154,-0.027056813,-0.025190488,-0.049990308,0.04957232,0.010745442,0.005267443,0.010952278,0.051157486,0.025863327,0.02715936,-0.08475424,0.040618893,0.009401738,0.022374455,0.03483195,0.028264279,0.015827093,0.008091188,0.06417426,-0.031373214,0.03917936,0.0015575836,0.013452261,-0.04533313,-0.032163437,0.012821785,-0.03725615,0.061113954,0.022355856,0.06578067,-0.096430704,0.08065067,0.035549466,-0.020565936,0.09794627,0.073803045,-0.01546116,0.010456975,-0.06941991,-0.09422452,0.021658234,-0.1140243,-0.053383652,0.027085096,0.041035343,0.029230177,0.0326421,-0.09999271,-0.07054954,-0.026294766,-0.0058792527,0.12673803,0.04582873,0.016363911,-0.05800466,0.028164297,-0.010111687,0.03888508,0.103317425,-3.8102325e-08,-0.022090781,-0.0144846635,0.05549264,-0.02630746,-0.03151625,-0.005349568,0.013409935,0.0030485578,0.0054226085,-0.01217517,0.057656776,0.008006412,0.053583086,0.062097255,0.05525294,-0.019902691,0.049144775,-0.01664378,-0.04529574,-0.026460389,0.024766577,-0.005306896,-0.08380731,-0.04772055,0.064131,-0.050915185,-0.035697695,0.010522308,-0.029617539,-0.008884849,0.046600193,0.02122999,-0.023351535,0.042261656,-0.043486733,0.08662003,-0.028740874,-0.048526056,0.012652168,0.02077111,-0.022073623,0.03222003,-0.045620013,-0.016110767,0.0028037806,0.032831702,0.01542691,-0.011616979,0.052613962,0.026774963,0.011502279,-0.024601925,0.0060918718,-0.037878294,-0.06595851,-0.10878068,-0.026644584,0.06685088,0.0116467625,-0.06904924,-0.026588263,-0.01890492,0.16356073,0.036608674 +4.2.3.49,"The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [1]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.",384,1.0,-0.034535293,-0.047362298,-0.024275685,0.033084612,0.074037656,0.06829985,-0.005932966,0.042288218,0.09956057,-0.028832138,0.070889905,-0.09677743,-0.027218116,-0.019268319,-0.001819747,-0.018752905,-0.039044578,-0.008410044,-0.041554913,-0.03716246,0.042271074,0.03393866,-0.031165851,0.02850109,-0.03191873,0.023693956,0.014408409,0.0069216937,0.022329867,-0.057118382,0.055412624,-0.010478516,0.027493626,-0.021681743,0.0035694006,-0.025604108,-0.013680478,-0.072114535,0.065430015,0.07982715,0.012060689,-0.024213849,0.030025838,-0.050145008,-0.1844522,-0.08781343,-0.03509474,0.021759307,0.059422925,-0.072676286,-0.022331348,-0.012821392,-0.08264234,0.01012134,0.015651405,-0.07459159,0.09258661,0.048884016,-0.030939743,0.022376832,0.12933792,0.029852947,0.018169496,0.06285426,-0.124362096,-0.051339712,-0.0020815535,0.05468814,0.015857652,-0.011893624,-0.05208914,-0.08001476,0.002633552,0.02403713,0.0061820806,0.021330377,0.0058991495,-0.047363803,0.060687616,-0.09105019,0.0017712145,0.040686086,0.037578896,0.09762499,0.06365025,0.04244934,-0.01814085,0.017106513,0.095472775,0.049549237,0.059461668,-0.008802497,-0.04123721,-0.00044547065,-0.04650839,0.16173208,0.041003663,-0.069447234,-0.06994898,-0.035498787,0.01271084,0.048429668,-0.14524737,-0.0597553,-0.012548995,0.10424219,-0.018763395,-0.060303204,0.025894927,-0.010789101,-0.029126946,-0.039980415,0.047374196,0.018605731,-0.117193386,0.058103077,0.020641984,-0.05097072,-0.01117084,-0.08540344,0.0232714,-0.047036882,0.0012687242,-0.03254903,0.0005986871,-0.0325666,-0.021857686,1.0909511e-33,0.0028316726,0.03279558,-0.08816916,-0.024833737,-0.019138219,-0.09737041,-0.046160087,0.08455998,-0.091811545,-0.030988416,-0.08850544,-0.10012651,-0.014459137,0.02828119,0.004220705,0.043573026,-0.0007181153,0.016071541,0.006436099,-0.07818299,-0.015719518,-0.03870969,-0.036942966,0.02038255,0.010000704,0.08127749,-0.007936812,-0.00484987,0.04516513,-0.026889993,0.007938548,-0.06924927,0.0065429634,0.016795298,0.09045308,-0.012548497,-0.04879022,-0.036417432,-0.047782432,0.055793162,-0.029878106,0.057413276,0.03198619,-0.0032744405,0.022770144,0.009961806,-0.08762737,0.059713054,0.103240766,0.05870124,0.029955678,-0.033810344,0.13898727,0.033225376,-0.044567555,0.107611254,-0.06701155,0.024041152,0.015347304,-0.061504245,-0.02198031,-0.009581937,-0.018177345,-0.04286596,0.047647655,0.06233257,-0.038735095,-0.04785902,0.04978837,0.032487515,-0.06107615,0.002199508,-0.026377413,-0.032956902,0.10637477,-0.015406755,0.014035712,-0.03091994,0.042828042,0.034789987,-0.030700902,-0.07116674,0.054393195,0.0031482927,-0.06754693,-0.031993132,-0.017283382,0.02675248,0.0034709158,0.049016412,0.07548638,-0.08894403,-0.026988303,0.013186414,-0.05292179,-1.8051701e-33,0.013105284,-0.0048171342,0.060442377,-0.06871385,-0.060442105,0.059232138,-0.050638672,-0.028771972,-0.027276607,0.0030352129,0.012407647,0.049549293,0.04332001,-0.072430685,0.014836552,0.035174396,0.04690222,0.036805693,-0.007292243,-0.06689869,0.010487124,0.024249932,-0.033068776,0.059296187,0.006547314,-0.03127504,0.053974994,-0.026680727,-0.010925858,0.03865987,0.12417805,-0.045367643,-0.018585544,0.023277007,-0.016622044,0.065902025,-0.025866577,-0.0258653,-0.048879407,0.048675586,0.010869524,0.004651838,0.01058264,0.051108744,0.025506727,0.027309418,-0.084771655,0.04181815,0.008769556,0.022300165,0.03528501,0.030583773,0.016912032,0.007951197,0.063239686,-0.030397706,0.040039524,0.001107979,0.01292736,-0.04611601,-0.03241689,0.012879278,-0.036154237,0.061138406,0.022597376,0.06593252,-0.09650603,0.080900654,0.03559826,-0.02125585,0.09948778,0.07448192,-0.014739688,0.010829804,-0.06949141,-0.09460981,0.022104418,-0.114421695,-0.05286037,0.027020205,0.041069705,0.030149344,0.032220837,-0.099983044,-0.069090374,-0.026259022,-0.005148377,0.1281222,0.046157755,0.016476458,-0.057297107,0.028048871,-0.00960604,0.03831912,0.10364839,-3.804479e-08,-0.021276046,-0.014578576,0.054975946,-0.027469225,-0.031691253,-0.0049840696,0.014448178,0.0017929076,0.005279528,-0.012707936,0.0583898,0.008448803,0.052885246,0.06304434,0.05419097,-0.018118938,0.045554157,-0.017265478,-0.044550028,-0.025312074,0.024122793,-0.0036345213,-0.08563844,-0.049032103,0.06341007,-0.049874246,-0.03590567,0.012862253,-0.030201413,-0.00944989,0.046087213,0.02229091,-0.023808211,0.042749878,-0.04262584,0.08660035,-0.0285993,-0.046640333,0.012615287,0.019371672,-0.02285932,0.03372994,-0.045047026,-0.016843548,0.0018140002,0.03179316,0.0150892995,-0.010420408,0.054451443,0.026082609,0.011344845,-0.022527043,0.0055923285,-0.03791975,-0.065055996,-0.10986707,-0.027352761,0.06767191,0.01124181,-0.067786284,-0.026221877,-0.020007355,0.16219628,0.036088128 +6.3.1.14,"This amidase catalyses the last step in the conversion of an L-histidine residue in the translation elongation factor EF2 to diphthamide. This factor is found in all archaea and eukaryota, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36, NAD+---diphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98, diphthine synthase.",384,1.0,-0.015052961,-0.03379004,-0.07834863,-0.03709086,0.1019442,0.045722526,-0.077850886,0.09568681,0.013425853,-0.014932905,0.050894085,-0.073528536,-0.038361378,0.01681799,-0.07857169,0.031199068,-0.09865953,-0.052430745,0.022120127,-0.031646803,0.027594052,0.10530446,-0.02572006,-0.023887148,0.019140301,0.0028199921,0.017891616,-0.02176856,0.0053326194,-0.07533519,-0.006792607,-0.034822237,0.016628359,-0.089677565,0.10438145,0.037911966,-0.030301008,-0.03651225,0.06711159,0.05990185,0.052220564,-0.004310575,0.0010303811,-0.07987538,0.030803282,0.034056738,0.011108322,0.061152767,0.083918616,0.005585605,-0.0557746,-0.04134231,0.016256327,-0.019798532,0.03651016,-0.063002005,-0.038364965,-0.030195981,-0.024624394,0.029679518,-0.008232665,0.0016991715,0.030929446,-0.029112415,0.058438774,-0.051313598,0.07554999,-0.08968079,-0.011948359,-0.00028428374,-0.14568554,-0.049156725,-0.0056996285,0.055059712,0.06462146,-0.0026231592,-0.046426795,-0.024905475,0.03568797,0.025281603,0.02682412,-0.032746643,-0.03353588,-0.011004299,-0.027751192,-0.031302277,0.029615914,-0.017475106,0.08654394,0.016277978,0.025285404,-0.09746182,-0.047636073,-0.011174591,-0.08219894,0.022217683,0.013097958,0.07162854,-0.0016806005,-0.037226226,-0.03287862,0.041854613,-0.0864819,-0.065379396,-0.044491637,-0.032130267,0.04944072,0.12434625,0.013723476,-0.01844383,0.037164178,-0.023799084,0.017572828,-0.09354575,-0.011883752,0.044894904,0.046692718,-0.11540517,-0.0563334,-0.053636562,0.030367622,0.019572873,0.045927167,0.14098898,-0.019021714,0.0072919508,-0.1321716,1.53659455e-33,0.105561,0.11273883,0.035660613,0.006450416,-0.050351825,-0.010450043,-0.118208,-0.008493365,0.036777057,-0.086201824,-0.055435542,-0.07200128,0.08928678,0.0033545534,-0.036541287,-0.05784401,0.03146431,-0.027044587,0.03510806,-0.026267707,-0.0006294204,0.019980853,0.025547348,0.0053243027,-0.0037103887,0.05064362,0.003219101,0.0037464073,0.03061231,0.008225797,-0.043862265,-0.062658794,-0.14024597,0.011199279,0.062659904,-0.065856166,0.003236246,-0.08809509,0.04030673,0.02758149,0.0392089,0.07974732,0.03343585,-0.07361605,0.03498549,-0.0728916,0.0028519947,0.048993595,0.049289726,0.011255641,0.043896798,-0.051342852,0.14040238,-0.04168083,-0.057736002,0.0006891684,-0.011437798,-0.05667986,0.05315003,0.095045105,-0.02275448,0.036314745,-0.047677957,0.04892863,-0.04824674,0.02123422,-0.025533203,-0.019614987,0.0438109,0.047317203,-0.028691992,-0.04194742,0.090743266,0.052499443,0.016732082,-0.0790374,-0.11360891,0.03087392,0.029010052,0.0085996045,0.010457614,-0.020601962,-0.045790266,0.011238512,0.02345514,-0.01936869,-0.008760551,-0.030964918,0.050849125,0.08593689,-0.030433293,-0.030794067,0.016580086,0.006663418,0.065673396,-3.715401e-33,0.09111711,-0.11715927,-0.009281494,-0.09538017,-0.026334094,0.0020970593,0.04254965,0.07409607,0.055494208,-0.018936379,0.0607416,-0.006839112,0.059811786,-0.07089066,-0.038482975,-0.032716464,0.02561925,0.07779032,0.0018360076,-0.040607277,0.045095485,-0.029679468,0.0398584,0.016582588,0.027176939,0.04067147,-0.037517514,0.075524434,0.020281151,0.011139878,-0.06289115,0.006906966,-0.040776823,-0.015136275,-0.012740499,0.020449648,-0.016954012,-0.0034193674,0.031386428,-0.045572396,0.040315937,0.043980766,0.013910252,0.021909205,0.051105846,0.09680455,-0.03440274,0.037997916,-0.006209981,-0.09846803,0.0023703848,0.037405223,0.033721797,0.015483236,-0.022786079,0.00466734,0.018208649,0.0030009956,0.05424911,0.013610382,0.0032142007,-0.082840174,-0.03683343,-0.051761772,0.03982741,0.047494944,-0.018916195,0.03643759,0.0203489,-0.031338006,0.07606839,-0.030257871,0.04732976,0.0062433546,-0.061978556,-0.030209761,-0.034418795,-0.061280284,0.08844011,-0.0493071,0.017157366,-0.08312624,-0.00036429707,-0.03439499,0.007004277,-0.044866357,0.025532423,0.06545645,-0.0690994,-0.0405035,-0.022989599,-0.028698744,-0.027449995,0.0744386,0.08076816,-4.290959e-08,0.028297387,-0.022639334,0.004700323,-0.05317257,-0.0011843313,0.06310377,-0.003928345,0.0033671996,0.0536319,-0.049970284,0.041106988,0.07398105,0.0030890862,-0.018181413,0.021862427,0.018068662,-0.054358218,0.05838272,-0.01125377,0.05182756,-0.020973131,-0.025282944,-0.049312945,-0.033108532,-0.02774223,-0.0420385,0.050179932,0.0374901,0.031493954,-0.12733969,-0.021175195,0.024444899,0.01580161,0.0036785419,-0.10936482,0.03802954,-0.041213218,-0.01794586,0.03158044,0.035042074,0.00558158,0.009017385,-0.10954673,-0.025410326,0.0075930874,0.068998694,0.0061104544,0.055273414,-0.063126765,-0.06926968,0.031091055,-0.01113064,0.06946437,-0.022720026,-0.079640515,-0.02400084,-0.058703344,-0.060351633,0.022193596,-0.029590359,0.06192672,0.035810467,0.14679605,0.061319385 +2.7.7.69,"This plant enzyme catalyses the conversion of GDP-beta-L-galactose and GDP-alpha-D-glucose to beta-L-galactose 1-phosphate and alpha-D-glucose 1-phosphate, respectively. The enzyme can use inorganic phosphate as the co-substrate, but several hexose 1-phosphates, including alpha-D-mannose 1-phosphate, alpha-D-glucose 1-phosphate, and alpha-D-galactose 1-phosphate, are better guanylyl acceptors. The enzyme's activity on GDP-beta-L-galactose is crucial for the biosynthesis of L-ascorbate.",384,0.99999994,-0.04684964,-0.04984772,-0.08497207,0.03866482,0.0423143,0.080585286,-0.034102157,0.001979734,0.0027051377,0.024626294,0.04052314,0.073557064,-0.08841782,-0.07680428,-0.080699936,-0.025160503,0.021702943,-0.0009192292,0.013828908,-0.00983276,0.14770527,-0.023524301,-0.012964973,-0.04748619,0.12950619,-0.08174503,-0.028821293,-0.10015557,-0.02359742,-0.12913662,-0.007007474,-0.07257518,0.08432023,0.011757618,-0.0015054081,0.07115124,-0.004307849,-0.06363018,0.051278215,0.011313983,0.030197201,-0.04350243,0.002274254,-0.028541084,-0.09387788,-0.03418308,-0.03865295,0.02335487,0.021241711,-0.038180657,-0.041107554,0.014366912,-0.031393617,-0.06845554,-0.034709565,0.08111786,-0.01638015,0.052716434,-0.026243646,0.07136047,0.035060003,0.03642753,0.01514626,-0.009107618,-0.0150796315,-0.08100544,-0.02490723,-0.022496104,-0.012774123,-0.0012315088,-0.009923145,-0.053366553,-0.013393954,-0.0046646846,-0.01546284,0.056043357,-0.06753968,0.013962852,0.059031602,0.011285056,0.06270276,0.03370379,0.004917598,-0.009620988,0.014057212,0.021656055,-0.027786544,0.12368511,0.0609247,0.027377686,0.04787001,-0.010821115,0.004697343,0.023771198,-0.031727612,0.030430572,0.08587947,-0.06612284,0.021845762,-0.09756107,0.028023094,0.06805547,0.060677934,-0.066784814,-0.06569699,0.060829513,-0.07019315,0.007808962,0.069982275,-0.020099679,-0.025590304,0.013109553,0.01226427,0.00029489282,-0.07682321,0.078823075,0.020027943,-0.06889711,-0.06318313,-0.02529203,0.05093,-0.02594744,0.010434647,0.08055701,-0.030160682,0.063816175,-0.023381859,-1.279365e-33,0.05340494,0.0785648,-0.07717488,-0.031278484,-0.04647902,0.03681037,-0.08091347,0.012947157,-0.040990103,0.009717863,-0.076350614,-0.0742258,0.004171055,0.048652373,-0.036620628,0.020322526,-0.0023729717,-0.0327571,0.09414762,0.011356924,0.014797676,0.01324348,-0.11880383,0.0299141,0.012312572,-0.006798623,0.025509391,0.049133662,0.05134081,-0.01868407,0.061662152,-0.07829923,-0.056491945,-0.01917112,0.048443876,-0.04911207,-0.05502263,-0.027703106,0.032639045,0.0020712356,-0.001646858,0.07072833,-0.006547791,0.00035021687,-0.01014254,0.039651155,0.007871729,0.017836953,0.07441037,0.032887984,0.00015193938,-0.0021525708,0.04353935,0.08033725,-0.007875212,0.054781035,-0.04441741,-0.013806525,0.034075197,0.020043636,0.052264277,-0.014064094,-0.019834267,-0.004434142,-0.002467433,0.048338696,-0.044110868,0.005512279,-0.014771685,0.07141697,-0.062092856,-0.12598382,0.037711464,-0.0143126,-0.001399544,-0.0058226516,-0.01174532,0.05273979,-0.011952048,0.012890552,-0.022960976,0.046296325,-0.03250854,-0.044166114,-0.006433397,0.03248536,-0.020339318,-0.06035646,0.01823691,0.026491582,0.04725842,-0.017785987,-0.0025367213,0.020055057,0.008523661,-4.740041e-34,0.08729322,-0.10419559,0.12901533,-0.016504206,-0.041216444,0.012779793,0.08656676,-0.10413795,0.04483949,-0.016534677,-0.0034680031,0.024702635,0.0016267607,-0.05007922,0.026904825,0.014222948,0.013880881,0.12518178,-0.05604854,0.04075898,-0.017683284,0.13337715,0.025823753,0.042982887,0.03935432,-0.019721014,-0.00013797512,-0.0015965091,0.014052912,0.031534135,0.115304716,-0.027075298,-0.040693182,-0.06784026,-0.08803143,0.0077109383,-0.084080264,0.028145557,-0.022293745,0.014309927,0.016390866,0.049137607,0.031001288,-0.01434163,0.07330801,0.018168835,-0.047270846,0.0010146976,0.008734895,-0.025194319,0.0058196923,0.025794119,-0.04641638,0.003501044,0.0364184,0.019257149,0.056703415,-0.014919224,-0.04757592,-0.039904922,-0.03526157,-0.06971519,0.038994018,-0.05476552,0.039987803,0.06165709,0.065132275,0.067781314,0.020197924,0.03376883,0.0474027,0.0035088672,0.039654803,0.114373714,0.011576309,0.013341949,-0.0946189,-0.02989075,-0.050408587,-0.06125938,-0.0025242702,0.044469047,-0.06675647,-0.09076115,-0.02541047,-0.049452927,0.029792123,0.09924709,0.03606722,0.07320209,-0.12769647,-0.054776866,-0.009739187,0.039413907,0.124081306,-3.9071615e-08,0.0023262128,-0.007944312,0.038497806,-0.085757956,-0.040451135,0.0038691997,0.0050607715,-0.015528283,0.055253975,-0.0589654,-0.049436167,0.126093,-0.005939976,0.039691847,-0.001999906,-0.023252213,-0.038890727,0.09132911,0.007899465,0.050332863,-0.023033716,0.010367555,-0.14710037,0.005470363,0.019611254,-0.06753882,0.023503136,0.056305096,0.03170908,-0.019102294,0.05092816,0.055938665,0.07025199,-0.038536068,-0.06980704,0.014439638,-0.03457084,0.013705203,0.04557681,-0.009045924,0.020440275,-0.07108996,0.031873107,0.030223759,-0.10232007,-0.002508995,0.02117397,-0.009901838,-0.0095589515,0.08799851,0.00022251892,-0.027768347,-0.091835365,-0.0913087,-0.013500018,-0.03822044,-0.031420384,-0.02157803,0.0062672882,-0.077186294,-0.013977592,-0.04171688,0.11886476,-0.07505264 +1.1.1.307,"Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH [cf. EC 1.1.1.431, D-xylose reductase (NADPH)]. However, a few D-xylose reductases, such as those from Neurospora crassa [5], Yamadazyma tenuis [2,3], Scheffersomyces stipitis [1], and the thermophilic fungus Chaetomium thermophilum [4,7], have dual cosubstrate specificity, though they still prefer NADPH to NADH. Very rarely the enzyme prefers NADH [cf. EC 1.1.1.430, D-xylose reductase (NADH)].",384,0.99999994,-0.006642707,-0.044488363,-0.0765854,-0.039598692,0.03998334,0.03548524,-0.041523617,0.018242525,0.026765391,0.022569183,0.00082313427,-0.013932533,-0.04625496,0.04065473,-0.040188614,-0.0059773754,0.011099214,0.0049369847,0.009386164,0.0068243393,0.11590458,-0.01410922,0.040317405,-0.005127418,0.05800844,-0.05119624,0.012858617,-0.07690617,-0.101051696,-0.060024757,-0.095430106,-0.047064736,0.009263609,-0.03474037,0.03914361,0.07339467,-0.061171204,-0.015258224,0.0167061,0.025828272,-0.015941674,-0.009169705,-0.030396942,-0.002984427,-0.14705296,-0.028677696,-0.02132668,0.03527241,-0.007372927,-0.030627426,-0.0014849568,-0.030793177,0.014740864,0.059416853,0.09881091,0.06284946,-0.028749058,0.008482682,-0.03502662,-0.04142699,0.027852261,0.001535986,-0.013791641,-0.0030390706,0.017285228,-0.06587586,0.040683094,-0.034625422,-0.042699665,0.01525513,-0.097923994,-0.004156283,0.0043830774,-0.031512816,0.045244876,0.05823867,0.052760273,-0.048981484,0.028283862,-0.0064030127,0.040659484,0.07978487,0.04245248,0.014193869,0.08840554,-0.0055666147,-0.017901257,0.0068745683,0.0003138008,0.0016960195,0.04338046,-0.0008832015,0.025702998,0.0031407876,-0.10678857,0.04321375,0.099387966,0.04462674,0.06148859,-0.10611065,0.0060106167,0.06554797,0.041265864,-0.07238275,-0.04155749,-0.021352997,0.00025350266,0.13081338,-0.012222676,0.009110632,-0.0045791245,-0.01924358,0.052288387,0.00718808,-0.05214558,0.06306296,0.024595724,0.0014524218,-0.10318958,-0.03642645,-0.027172381,0.008594907,0.017685203,0.03382386,-0.010990359,0.039532702,-0.10634334,4.0862498e-33,0.07100026,0.078402415,-0.073749006,-0.046997942,0.004937937,-0.017271426,-0.056118615,0.08404668,-0.041095834,0.012208398,0.039768804,-0.075757414,0.009527398,-0.01642767,-0.024671907,0.012944247,0.024275796,-0.037939765,0.020592194,0.033538014,0.029238164,0.09945168,-0.030525502,0.0119373575,0.010269452,0.01431375,-0.022359675,0.030298816,-0.03193869,0.0016838096,-0.020989297,-0.105048046,-0.06792965,0.09855171,0.08920914,0.02555882,-0.07183,-0.038610157,-0.022068612,0.001089791,-0.064650305,0.059116285,-0.020044357,-0.068258695,0.07929606,-0.066146314,-0.047862932,0.06574711,0.031688757,0.063318215,0.020707944,0.038625978,0.13906421,0.05856895,-0.049949307,0.019278597,-0.006272029,0.0030294375,0.017132875,0.022625236,-0.012860232,0.044820767,-0.062391337,0.005162723,0.00075603294,0.041762665,-0.06465097,-0.11387881,-0.0437371,0.057172857,-0.07278175,-0.033405524,-0.005129626,0.02416223,0.05711228,-0.060122605,0.0179471,-0.020972293,0.03041736,-0.0032270087,0.022994997,0.00044810591,-0.036051393,-0.060598005,-0.032647375,-0.013558929,0.004413332,-0.03709137,-0.026073761,0.029909855,0.01420415,-0.073501796,-0.0064502396,0.013678308,0.03823588,-3.6262774e-33,0.08280703,-0.07011875,0.0523615,-0.0677496,-0.06749075,0.10446406,0.07446178,-0.100620046,-0.021264084,-0.122230366,0.045735028,0.026442107,-0.033775207,0.006782895,0.0024264113,0.07003032,0.01833584,0.055318814,0.009862415,-0.041339573,-0.002881731,0.16903222,-0.028841347,-0.007210574,0.061984334,-0.013104699,-0.0019984748,0.117428795,0.04428067,-0.012444532,0.0021796655,0.028833935,-0.009806225,-0.049892213,-0.092140265,-0.0016070601,-0.1546022,0.036961343,0.015880214,0.102763735,0.029310625,-0.014308291,0.0023294946,0.05539692,0.08448106,0.042458836,-0.15964918,0.025086949,0.07540884,0.029995067,0.026100237,-0.00052648614,-0.048102975,0.0020811334,0.017146615,0.034714356,0.014282685,-0.00013719746,0.04121397,0.0017611777,-0.03171128,0.007842468,0.042131376,0.07305179,0.0692953,0.0109475795,-0.012600123,0.016900511,0.047960367,0.016317273,0.06649124,0.018023567,-0.011031058,0.013423069,-0.0028009305,-0.07938611,-0.09412429,0.0582576,0.0005673564,0.05191222,0.01443861,0.07991972,0.06455466,-0.022199634,0.053391054,-0.021936676,0.002450029,0.03628381,-0.054321613,-0.005851239,0.0024499593,-0.05045088,0.034686156,0.03719292,0.096891545,-4.3328004e-08,0.058742505,-0.007716138,0.035628013,-0.073259465,0.031932108,-0.020244278,0.015894946,-0.034381896,0.036129992,0.0070852065,-0.026448265,0.0981923,0.0780433,0.057055816,0.033618186,-0.005126215,-0.0020247975,-0.015003926,-0.049563024,-0.012402394,-0.049741942,-0.06199055,-0.1703381,0.09870563,0.0034259472,-0.04483628,0.04985932,-0.03062236,0.0025447905,-0.031393804,-0.05250023,0.03551961,0.07339455,0.0028903026,-0.03956072,0.05950718,-0.06790389,-0.018606266,-0.017258978,0.027949074,-0.0006875724,-0.07477277,0.0034910107,0.05497502,-0.030654056,-0.06581779,0.01228026,-0.0049236934,0.026850577,0.025570335,0.038775843,-0.013112519,-0.04064888,-0.09198711,-0.07519068,-0.007230116,0.024864698,0.01738472,-0.025410205,-0.045197926,0.050730485,-0.050743777,0.11081107,-0.085363865 +1.1.99.36,"Contains Zn2+. Nicotinoprotein alcohol dehydrogenases are unique medium-chain dehydrogenases/reductases (MDR) alcohol dehydrogenases that have a tightly bound NAD+/NADH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. +The enzyme from the Gram-positive bacterium Amycolatopsis methanolica can accept many primary alcohols as substrates, including benzylalcohol [1].",384,1.0,-0.098163724,-0.046323363,-0.084562846,-0.07139733,-0.00178529,0.037063558,-0.09568472,-0.0011743052,0.013637615,-0.06563012,-0.03466478,-0.019561771,-0.12556927,0.053058416,-0.0482594,0.04931428,-0.039811186,0.00050927396,0.07148583,0.015136932,-0.0048154416,0.05815364,0.018857464,-0.07046276,0.015347376,-0.015391345,0.006429377,0.01605487,-0.0069017196,-0.06240836,0.059380524,-0.012778351,-0.0061395313,-0.008405843,0.020275315,-0.01603228,-0.048421897,-0.03632065,0.0028084104,0.011028683,0.07194645,0.049526136,-0.07204528,0.01433282,-0.06464587,-0.033959,0.0056142597,0.039027024,0.03168101,-0.04461616,-0.06818702,-0.04664224,0.044909894,0.061325148,0.090236306,0.067378424,-0.0017048143,-0.020109717,-0.009541607,0.031996578,0.041130092,-0.011964307,0.047891114,-0.043151826,0.05451872,-0.043258227,0.017316647,-0.048700564,0.009109893,-0.009135377,-0.10463751,-0.02106473,0.030274814,-0.032277066,-0.0823545,0.030575423,-0.06475336,0.01360542,0.03129335,-0.018514033,0.012046839,0.023718216,0.032585848,0.10384765,0.09287406,-0.05394712,-0.00864705,0.03187886,0.055126958,0.06894933,-0.04297657,0.041337326,-0.013628522,-0.015719268,-0.09854513,0.012821632,0.09181131,0.02285629,0.014897394,-0.025593257,0.04505359,0.08034531,0.05041013,-0.11287917,-0.11366444,0.06599633,0.036247794,0.08074664,0.005834193,0.059330095,0.038144372,-0.0039953617,0.016577262,0.0003222231,-0.041422088,0.049321823,0.004838221,-0.07622769,-0.03647391,-0.048078366,-0.055133775,-0.008913603,0.08619034,-0.020224867,-6.1252016e-05,0.08441289,-0.120694876,3.1538385e-33,0.018456077,0.04990701,-0.047850292,0.026850188,0.067723386,-0.040726267,-0.0705839,0.048391916,-0.03272261,-0.047463175,-0.030541612,-0.08805047,0.021054368,0.014260957,-0.014195085,0.0040806043,0.030189052,-0.03438242,0.029307036,0.052047327,0.047047585,0.002549136,-0.076654196,-0.011646321,0.012317256,0.0076421085,-0.03807532,0.033421885,0.021974452,-0.012623761,0.014276928,-0.10474336,-0.051051844,-0.0022096382,0.09893261,0.06303131,-0.013676149,-0.0030112078,-0.047763713,-0.00045711777,0.036625978,0.04722485,0.054952696,-0.009809963,-0.021105545,0.0032360663,-0.06105514,0.044615544,0.010393101,0.03265709,0.037721977,-0.06289527,0.0661595,-0.0934916,-0.06842824,0.06341432,-0.055204753,0.024265261,0.030407622,0.04141009,-0.06829058,-0.016836146,-0.058588445,0.0060350345,0.008344144,0.0018571205,-0.038388446,-0.0919804,0.014831536,-0.009182965,-0.028526956,-0.005864805,0.115343,0.029665923,0.0076491055,-0.02808401,-0.026032358,-0.019874847,0.11035766,0.042747308,0.027385604,0.00823086,-0.038253225,-0.08406383,0.010431548,-0.06900249,0.013723288,-0.06556567,-0.032499857,0.015422968,0.019006867,-0.1064923,0.031876773,-0.009991927,0.025165277,-5.4084506e-33,0.09170955,-0.071998246,0.08548992,-0.13428336,-0.035168182,0.13871086,0.029355476,-0.0024106156,0.018657355,-0.04891826,0.08622732,0.033824693,0.05763642,0.02457785,0.0053424295,0.006746766,-0.052454658,0.09432172,0.027302468,-0.054052163,0.0389985,0.0817732,-0.013459854,0.034560602,-0.018872643,0.0018967148,0.010551338,0.038823098,0.011419831,0.040746912,-0.006346893,0.043284364,-0.07136001,-0.074319795,0.0007491327,0.034077954,-0.08785457,-0.036926255,-0.024225151,0.022181433,0.034809668,0.013595204,-0.02437206,0.029935382,0.017461684,-0.008806989,-0.09527188,-0.03564913,-0.008117003,0.01471007,0.07498468,0.008965673,-0.07826924,0.06412592,0.05676146,0.07367555,0.036083013,0.0015865148,0.022837397,-0.015833037,-0.082985155,-0.048204165,-0.0019067988,0.030753,-0.0099593885,-0.0056519834,-0.029575842,0.113056354,0.011387507,-0.06572842,0.020341251,0.07619724,0.037288625,0.10667228,-0.07337577,-0.052112624,-0.089658886,-0.04173936,-0.029321192,-0.016210971,0.03283522,0.002918636,-0.02905802,-0.049840007,0.04404468,-0.060898524,0.09954514,0.024927022,-0.034030996,-0.018322991,0.03105291,-0.03226567,-0.074056804,0.06401406,-0.068869546,-4.63472e-08,-0.0034789816,-0.034571946,0.04210803,-0.050282564,0.0056483406,-0.014277666,-0.021551866,-0.043847844,0.04608517,-0.027680574,0.051364534,0.100680806,-0.02323624,0.061823998,0.018277423,0.014175841,-0.05092083,-0.014691086,-0.03458734,0.006300232,-0.045442127,0.05444567,-0.08279955,0.05741953,0.012401395,-0.03965087,0.004893825,0.0033876973,0.040809266,-0.07972973,-0.029204875,0.07679017,0.03950628,-0.028470373,-0.079944216,-0.087011695,0.012522247,-0.0732473,-0.045737315,0.021611871,0.054667864,-0.064997636,-0.022943636,-0.030798072,0.010739686,0.0007604814,-0.030474499,0.03724206,-0.0467926,0.08199086,0.05164454,0.044265576,0.02745078,-0.06714155,-0.10089614,-0.021962872,-0.031033536,0.027208287,-0.021263229,-0.05941385,0.064166136,-0.004763562,0.19092909,0.0249811 +1.1.99.37,"Contains Zn2+ and Mg2+. Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis [1-3]. These enzymes are decameric, and possess a 5-fold symmetry [4]. Some of the enzymes can also dismutate formaldehyde to methanol and formate [5].",384,1.0,-0.10828963,-0.029502347,-0.06542992,-0.053588398,-0.013581761,0.019630559,-0.09904031,0.036656003,-0.015346905,-0.011180726,-0.050894413,-0.022920974,-0.0614388,0.06617881,-0.051397573,0.046308875,-0.019598069,-0.016492764,0.015012803,0.040030133,0.059617933,0.0860308,-0.030274285,-0.07448055,-0.020184949,-0.0071797823,0.044467162,-0.0244127,-0.0262465,-0.04548172,-0.0030247257,-0.0034039498,0.044172022,-0.02897767,0.08170945,0.032689877,-0.024289114,-0.025849976,0.029430242,0.0068595926,0.040715177,0.033404376,-0.035517156,-0.0042764074,-0.021464225,-0.05931524,-0.004773865,0.011748198,0.048226103,-0.08237385,-0.04255093,-0.026748398,0.008906746,0.09055989,0.06383557,0.04421586,-0.02345485,-0.05866573,-0.026809448,-0.014933683,0.027216531,-0.033100005,0.0442104,-0.08406707,0.045902606,-0.017093612,0.040878274,-0.09011444,0.052662183,-0.011505125,-0.09097372,0.015059455,0.023556804,-0.03743565,-0.0773466,0.051815454,-0.018126624,-0.0059784567,0.061992917,-0.028591579,0.057638682,0.07398549,0.060331546,0.039632123,0.10890418,0.010222873,-0.002968841,0.0354198,0.04333531,0.0383912,0.008911764,0.029446667,0.01057594,0.011277159,-0.13709074,-0.01968126,0.047266234,0.04238338,0.033509422,-0.006452751,0.035536855,0.06814376,0.0043657254,-0.082530275,-0.106512,0.06463829,0.062096555,0.069780044,0.025267377,0.066789106,0.020528952,0.022232579,-0.016533405,0.031731237,-0.034895875,0.04748097,-0.007166479,-0.072091885,-0.062163122,-0.028153036,-0.025774736,-0.07575761,0.05875281,-0.051504005,0.006074294,0.07715024,-0.11129589,5.9720296e-33,0.0323415,0.054798707,-0.03656057,-0.027946558,0.053164087,0.029387252,-0.08126088,0.06291682,0.009142886,-0.026032528,-0.014738302,-0.08006386,0.04942372,-0.00067712314,-0.06422881,0.03407059,-0.019798413,-0.014589608,0.018775547,0.03894418,0.035515983,0.040931556,-0.057269033,-0.01875325,-0.002251263,-0.012388433,-0.082890704,-0.0067206896,0.057590485,-0.009355651,0.060653534,-0.1742994,-0.0602347,0.0126570165,0.09179637,0.051722974,-0.042938277,0.009346728,-0.032024793,-0.017561339,-0.03134427,0.044280894,-0.015373789,-0.017923545,-0.008644752,-0.015187908,-0.03736676,0.04434455,-0.0009196606,0.03487357,0.050423447,-0.008099579,0.041589607,-0.09200541,-0.05550655,-0.0049901917,-0.01553835,-0.034114916,0.06043174,0.032027178,-0.019729925,-0.0010763096,-0.020068655,0.008021963,0.022514435,0.0081711365,-0.044648167,-0.074252,0.04810714,0.046226196,-0.022372508,-0.03724851,0.055693135,0.040252656,0.011638358,-0.078596614,0.0004253685,0.005820667,0.084601335,0.02698847,0.06434378,0.04382612,-0.007388115,-0.09151059,-0.008241871,-0.021743516,0.012251214,-0.06724386,-0.03777848,0.019724626,0.069165826,-0.10418376,-0.010130224,0.0022277585,-0.015554939,-6.3001156e-33,0.084735654,-0.040586293,0.04783256,-0.10786589,-0.04341845,0.10201587,0.033136904,0.010152993,0.020240678,-0.09526034,0.16483508,0.051694576,0.06000761,0.078718916,0.06587284,0.03153045,-0.056002133,0.087106414,0.030189293,-0.058942296,0.041510344,0.039289188,-0.042139854,0.022024054,0.009443558,0.015770858,-0.00945155,0.018172637,0.04346682,0.051777605,-0.0033091193,0.060955726,-0.11558008,-0.06974648,-0.013110308,0.016383313,-0.08940421,-0.019156292,0.009582473,0.018204108,0.050847657,0.03325166,-0.0054622353,0.041887295,-0.012726819,0.022408824,-0.097499974,0.014914905,0.042819034,0.026702609,0.041130375,0.021593593,-0.07149773,0.037343815,0.044933293,0.106113665,0.026990002,0.021192495,-0.0048558027,0.0043827347,-0.08513936,-0.07920914,-0.0043188594,0.035457253,0.030433586,0.055867035,0.06194771,0.06649923,0.06551899,-0.041686896,0.013702142,0.1014617,0.0076615443,0.010566094,-0.08672014,-0.05169718,-0.06422251,-0.024322221,-0.01622142,-0.0065490147,0.074860156,-0.014864703,0.009946163,-0.050800383,-0.0010121585,-0.041057475,0.08177985,0.045157198,-0.033753328,0.0019447318,0.015885144,-0.03585793,-0.08747265,0.04959322,0.002395588,-5.246286e-08,0.019640772,-0.10227832,0.051170852,-0.10967302,0.0098595405,0.012660091,0.0035154477,-0.06811265,0.04198802,-0.0014581262,0.075989954,0.10067314,-0.09749807,0.042199865,-0.008902741,-0.0057647903,-0.06995159,0.005286313,-0.041136235,0.00027235987,-0.055995792,0.01653653,-0.087895334,0.06184582,0.025846548,-0.034407053,0.042323563,0.00815694,0.024517974,-0.06387321,-0.015946122,0.06489006,0.06364105,-0.06264198,-0.088645965,-0.09503395,-0.014414492,-0.038087357,-0.05467947,0.0125166,0.057613757,0.008082523,-0.010642652,-0.013745693,0.013728481,-0.046029024,-0.0077582602,0.011874153,-0.056491755,0.038468108,-0.0069031226,-0.00938363,0.005271003,-0.07585515,-0.13319485,0.0048928396,-0.03767393,0.011711931,-0.05180053,-0.009332867,0.010815992,-0.027563082,0.16315722,-0.018609583 +1.14.14.8,"This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase.",384,1.0,-0.06350072,0.010452797,-0.111293904,-0.0020988744,0.07528158,0.0060860957,-0.037449725,0.045937724,0.046003934,-0.009688686,-0.037216682,-0.04906859,-0.02633363,0.056700036,-0.11672057,0.017234022,-0.10758961,-0.036824364,0.04503538,-0.024879444,0.003055648,0.093853995,-0.016262313,-0.008643903,-0.0152978,-0.03843619,0.040675472,-0.03817279,-0.06434515,0.03230321,0.012849454,-0.03078842,0.031144204,-0.0058763875,0.042434685,0.17362693,0.0021223936,0.021197181,0.040221874,0.015971165,-0.014929664,-0.020058792,-0.004748864,-0.012206888,-0.005659811,0.0579322,-0.0040384517,0.043870285,0.024111988,-0.035185587,-0.056281567,-0.05894028,-0.04060785,0.057919614,0.114928044,0.054335434,-0.01062746,-0.07692957,-0.016965909,0.044043887,0.038008887,-0.011634682,-0.035120655,-0.009265472,0.11575725,-0.055847634,0.013015014,-0.069558404,-0.025051491,-0.037870657,-0.04172516,-0.004212383,-0.037857108,-0.025409041,-0.01983534,-0.0045013665,-0.056735896,-0.03588751,0.07560664,-0.032372575,0.06227191,0.045827728,0.08188911,0.08183956,0.00094143185,-0.035899978,-0.0027506165,0.0042268443,0.017575826,0.029379463,0.028526787,0.0055017252,0.0064601465,-0.058727283,-0.03028801,0.000512939,0.025959421,-0.032032836,0.033808883,-0.019965233,-0.026852911,-0.019168649,-0.004137698,-0.082582824,-0.07825305,-0.016105935,0.015272545,0.121033266,0.10322417,-0.0047524096,-0.035765972,0.02378482,0.030667163,-0.0016551955,-0.02092314,0.051133897,0.0071936264,-0.08948042,-0.082370356,0.026888087,-0.04595285,0.045899265,0.03218663,0.112213604,-0.02167556,0.020590968,-0.08741015,3.3680437e-33,0.093896694,-0.0083354125,-0.028708797,-0.012929669,0.008715436,0.03039304,-0.06609889,-0.043819748,-0.00019634354,-0.059131626,-0.06895456,-0.104969844,0.015829531,0.02564995,-0.007464988,0.02277107,-0.10867317,-0.011660081,0.030715672,-0.0034730928,0.009685561,0.050252333,0.010439382,0.008394644,0.03083272,0.07326536,-0.024544835,0.04053604,0.009041736,-0.0145381335,0.01903646,-0.06409312,-0.16830033,0.012461914,0.044531792,0.0029594942,-0.05638021,-0.022586027,-0.06834624,0.06955189,0.024995333,0.04199942,-0.018539716,0.00085954583,0.11187568,-0.013237599,-0.0032317492,0.16416314,0.0423139,0.09034317,0.04695161,-0.020996336,0.010557639,-0.053229406,-0.1002245,0.0062174406,-0.01438845,-0.02202475,0.04313737,0.011524216,0.018814102,0.037277225,-0.016904302,0.060269415,0.005166601,0.020430956,-0.008456267,-0.08827197,0.014339584,0.08332628,-0.043525897,0.014845955,0.090191536,0.015266577,-0.027322588,-0.06077224,-0.021103896,-0.020915283,-0.010511667,-0.014306596,0.025781292,-0.07141055,0.02804057,-0.077123664,-0.02685813,-0.024191566,0.005381588,-0.12999895,-0.051808096,0.015571771,0.028430777,-0.09311648,-0.10951597,0.058053795,0.03940146,-4.079788e-33,0.072423145,-0.1253251,0.06687655,-0.08202057,-0.064434774,0.04995581,-0.017155353,0.0025239827,0.017946178,-0.036843054,0.06567454,-0.0139694875,0.08269531,0.00067982986,0.035874225,-0.022023616,-0.024157275,0.078582585,-0.009965367,-0.0071054874,-0.0050289775,0.05808471,-0.0056686318,-0.029870497,0.012045813,0.055193733,-0.08913708,0.08326163,0.041237466,0.027949652,0.007242146,0.03249061,-0.12017401,-0.055679485,-0.024835944,0.06823934,-0.0830775,0.011690467,0.04486221,-0.019885119,0.0516362,0.048431966,0.03317041,0.03433465,-0.0055933776,0.10621433,-0.07676648,0.0207848,0.0274034,-0.08928475,0.010888304,-0.014751576,-0.024607394,0.029348383,0.023703186,0.054701243,-0.0029526865,0.056463625,-0.048203137,-0.058393262,-0.04681357,-0.06909153,0.090231255,0.027501348,0.059224926,0.04946248,0.020571206,0.058749277,0.055882648,0.07977418,0.09831738,0.004158923,0.033564296,0.020590942,-0.049799122,-0.0095922295,-0.07620822,0.009726191,0.0033203328,0.03751771,0.040777374,0.050847262,0.014948488,-0.013261948,0.00400225,-0.092808284,0.028674455,0.09504185,-0.003867752,0.011007695,-0.011206558,0.0136921685,-0.032336693,0.01341624,0.046553925,-3.6807528e-08,0.049789958,-0.05735939,0.020453786,-0.07171312,0.0357896,0.022781046,0.016726242,0.06502085,0.0004750231,-0.04271197,-0.009323166,0.078999236,-0.031862732,-0.033635575,0.033729967,-0.026171368,-0.049466304,-0.0026093055,-0.02682773,-0.04302607,-0.10928276,-0.046167646,-0.016608609,0.052147135,-0.029737562,-0.029167082,0.07769369,0.016332902,0.028645383,-0.045868523,-0.031252448,0.04146061,-0.0066355406,-0.035328854,-0.117848486,0.089043744,-0.04361157,0.026136111,-0.034004875,0.014097476,0.00071245845,-0.0063806484,-0.02860594,0.008472679,-0.05015827,-0.030983254,-0.010226057,-0.007537045,-0.0035383527,0.0051512006,0.02578313,0.0026411084,-0.04472156,0.021525543,-0.12281846,0.004955272,-0.038610682,-0.06389793,-0.016063336,-0.02832182,-0.021073217,0.0082599735,0.15428782,0.0022269608 +2.1.1.175,"The enzymes from Oryza sativa (ROMT-15 and ROMT-17) catalyses the stepwise methylation of tricetin to its 3'-mono- and 3',5'-dimethyl ethers. In contrast with the wheat enzyme (EC 2.1.1.169, tricetin 3',4',5'-O-trimethyltransferase), tricetin dimethyl ether is not converted to its 3',4',5'-trimethylated ether derivative [1]. The enzymes from Hordeum vulgare (HvOMT1) and from Zea mays (ZmOMT1) form the 3',5'-dimethyl derivative as the major product [2].",384,0.99999994,-0.10980323,0.019584555,-0.04017988,-0.048979662,0.056982804,0.03765022,-0.06997478,0.049898032,0.003322195,0.014758117,0.081090055,-0.072313026,-0.005016346,-0.031563863,-0.023711475,-0.006870896,-0.034716997,0.04716153,-0.045449574,-0.08539212,0.051029895,0.048079576,0.047737747,-0.028273733,0.012870848,0.009662315,0.0020611214,0.02449326,0.02459859,-0.08947246,-0.0028999175,0.1244524,-0.08128444,-0.086896986,0.0011352374,0.006839617,0.012611925,-0.12363308,0.06003573,-0.018356156,0.11505592,-0.009675467,-0.052884355,-0.07415903,-0.028730383,-0.059169155,0.021569986,-0.004910278,-0.003775203,0.007656921,0.000507864,-0.020722318,-0.007258889,0.051157836,-0.004721067,-0.025022652,-0.000286862,0.04602615,-0.053037494,0.08867388,-0.001976832,0.021189274,-0.07397241,-0.030787125,-0.044702876,-0.0009954836,0.040509075,-0.06786509,-0.004980459,-0.058807842,-0.072940074,-0.078501575,-0.06523151,0.04843476,-0.030606272,0.02134535,0.06902579,-0.0074123577,-0.009390269,-0.082476586,-0.05760736,0.036604334,0.11466866,0.031297192,-0.037682213,-0.028944876,-0.05187806,0.098089084,0.118451625,0.025464132,0.048750557,-0.013313755,-0.022997761,0.014519576,0.0033768266,0.080550425,-0.035965603,-0.028031468,0.015752163,-0.03332754,0.048519216,0.0217007,-0.060028404,-0.049188387,0.008336644,0.090726264,0.04408385,0.044685323,0.06161827,0.025207387,-0.04810836,-0.022083329,0.0672433,0.024481261,-0.11097534,0.051373072,0.018516298,-0.074006066,0.016837917,-0.067792036,0.066194095,-0.030818393,0.06584098,0.07684091,-0.010756342,0.024827067,-0.0960966,1.9953794e-33,-0.013587566,0.071674675,-0.005098883,-0.01607376,-0.02554267,0.040758077,0.007383382,0.030670676,-0.014359728,-0.06530948,-0.105442524,-0.042529028,0.0049296315,0.0050111017,-0.056838304,-0.04147223,0.013162133,-0.028794006,-0.017764065,0.0046521816,-0.054331567,0.06280271,-0.09717256,0.02580554,0.03412637,0.023572532,0.060235433,-0.0077831927,0.020397693,-0.01831,-0.033861876,-0.08241769,-0.0031048069,-0.001166784,0.08489222,0.09739487,0.0009951396,-0.0046674255,0.0002603842,0.114764415,0.0013784027,0.0054354547,0.016420485,-0.043943055,-0.010662154,0.027282178,-0.06355956,0.07833044,0.03486863,-0.021060128,0.009612208,0.03916376,0.040942673,0.035151187,-0.07752901,0.07566664,-0.03567192,0.012127592,0.024296816,-0.02123438,-0.035465304,0.03482115,0.01484159,0.05488461,-0.017468914,0.0032183,-0.06452097,-0.049925543,-0.016182091,0.11761237,-0.049108937,0.025611158,0.06193916,0.037039213,0.1281747,-0.0534192,-0.007886403,-0.007840123,0.052139647,-0.0026050664,0.05182118,-0.013118526,0.028505614,-0.08569478,-0.09865133,-0.038519852,-0.06235961,0.013990589,0.009723216,-0.031200035,0.08800434,-0.010189534,0.034668364,0.024927804,-0.06763846,-2.757869e-33,0.03471218,0.04021821,0.012675339,-0.06021355,-0.002609759,-0.004437593,0.052955788,0.010816755,-0.026373053,-0.05412574,0.11635569,-0.021210827,-0.0014956326,-0.09315071,0.010175846,0.046783853,0.011153299,0.08240596,0.0064445958,0.00068343745,-0.007281286,0.015316494,-0.06996729,0.081477836,-0.0033291273,0.022691453,0.0007800452,0.019230353,0.016225796,0.034884334,-0.0059243473,-0.090331055,-0.029461954,-0.043598235,0.04809006,0.07544923,0.033087913,0.039939895,-0.06096502,-0.017595919,-0.08636924,-0.022347227,0.061523892,-0.0038893032,-0.0071160165,0.04847446,-0.07284607,-0.044577993,-0.04359859,0.02238212,0.044345345,0.051910635,0.032524843,0.023357145,-0.0016810021,0.024727028,0.06483229,-0.018303385,-0.033363923,-0.033219572,0.02293173,0.0011967464,0.06974696,9.731929e-05,0.026295261,0.054734472,-0.044466525,0.009237251,-0.031135209,0.014650814,0.0033299613,-0.025359642,0.023397245,-3.923037e-05,-0.07078722,-0.024401711,-0.0090137515,-0.09074656,-0.056291692,-0.0863012,0.03459894,-0.031114032,0.00010763701,-0.065330535,-0.10096065,-0.04903964,0.050573353,0.16026701,0.04314493,0.017193997,-0.02436674,-0.061275136,-0.06205442,0.050359953,0.08487667,-4.6444e-08,-0.019513573,-0.15614429,-0.07100325,0.05141977,-0.053479657,0.072193794,-0.024077943,-0.014851581,0.0806637,-0.01912924,-0.017433697,0.08154271,-0.08853643,0.059576936,0.017251128,-0.0066566174,-0.060570396,0.028553197,0.01949084,0.0038836037,-0.021611014,0.037612274,-0.08229852,-0.030303024,0.022746436,-0.023597911,-0.017395657,0.10309288,0.08014976,-0.033464435,-0.025602104,0.04667013,0.008893669,-0.0017248589,-0.062502235,0.016808799,0.013103926,0.0077590626,-0.005415985,0.037259083,0.0071364306,0.0035613708,-0.0067888172,0.007222325,0.03889509,-0.117751464,0.034130882,0.0052759163,0.07204429,-0.026673142,0.040487826,0.040009275,0.03336045,-0.085187994,-0.016461492,-0.0207739,-0.050952032,-0.023885084,-0.017239098,-0.035661742,-0.015951587,-0.051962856,0.17907748,0.0370461 +2.1.1.176,The enzyme specifically methylates cytosine967 at C5 in 16S rRNA. ,384,1.0,-0.028534861,0.01737295,-0.076110944,-0.06984129,0.015572233,0.04752516,-0.09696365,0.01456771,-0.054145355,-0.009026944,0.0017610207,-0.038683746,-0.049328424,0.061753552,-0.06847988,0.05200876,-0.06238374,-0.02410101,-0.030463628,-0.007999617,0.022977527,0.05338706,-0.05073003,0.004361709,0.0069009583,0.01064433,0.041797705,-0.0010905863,-0.02424507,0.015041743,-0.02678077,0.06580739,0.020032661,0.004914296,0.025570083,0.07571281,-0.055417005,-0.053126477,0.02227862,-0.006708911,0.10627052,0.0903714,0.029914489,0.015687238,-0.017476823,-0.005014513,0.083934866,-0.023815883,0.042877443,-0.05749581,-0.04119299,-0.08480992,-0.01568106,0.048772186,0.007983269,-0.009325834,-0.07702939,-0.05024872,-0.008825663,-0.02929605,0.024783766,-0.060548823,-0.007243366,-0.019791426,0.029113134,-0.009092686,0.031760316,-0.02141546,-0.046291035,-0.042855825,-0.03757299,-0.017640257,-0.04431746,0.040160436,-0.039670333,0.021695156,0.08960869,-0.09795909,0.030795865,-0.035497263,-0.025522945,-0.005975591,0.030239824,0.013176077,0.027993407,0.036430117,0.05263849,0.056158364,0.037373472,0.020296361,0.04557534,0.017235346,-0.04641948,-0.060093258,-0.09305726,-0.011172838,0.05411629,0.010400789,0.07270675,-0.049684342,0.0982387,0.11667344,-0.06288804,-0.022277871,-0.03287218,0.023427373,0.0060282606,0.10611904,-0.05897247,-0.023921758,0.013988323,0.09607117,0.00044346816,-0.017488146,0.021672225,0.0009153299,0.01074201,0.0036648624,-0.017855227,0.015376464,-0.035078786,0.014483426,0.05651691,-0.0060541923,-0.039694436,-0.016426379,-0.16168919,1.5637434e-33,-0.030460987,0.016797457,0.033153538,0.009904957,0.04151593,0.012605748,-0.02319493,0.020733716,-0.031065805,-0.07357155,-0.12607259,-0.090490945,0.05413262,-0.05759708,-0.05615608,0.043688167,-0.03216313,-0.015548793,-0.033368472,-0.07146025,-0.024898382,0.060651947,-0.029523872,-0.051801823,0.0059950496,0.05510449,0.016723152,0.005246581,0.10442097,-0.047109198,-0.065825105,-0.023120752,-0.06400955,0.011191005,0.1242055,0.12457158,0.029883085,0.0041689477,0.036615487,0.04337377,0.053105947,-0.012361788,0.007748741,-0.017873898,0.022985592,-0.033099826,-0.12131625,0.029113071,0.01871198,0.028512973,0.050412394,0.0025657252,0.06681463,-0.030249745,-0.08496484,-0.024213735,-0.0276233,-0.008001874,-0.020279635,0.04969852,-0.008633392,-0.023961594,-0.05167852,0.0643844,-0.009380308,0.0059242696,-0.077137634,-0.08973798,0.019829243,0.08781107,0.0023467331,-0.0320186,0.15987097,-0.030924287,0.049354725,0.014131636,-0.04198783,-0.032731686,0.03775162,0.09180734,0.0050954428,-0.010606524,-0.018251587,-0.006612743,-0.047281887,-0.01853583,0.055258553,-0.04322745,0.032808866,0.07853793,0.07975841,-0.10483414,-0.02275574,-0.023279538,-0.05823622,-3.4088392e-33,0.09225823,-0.06604248,0.068276346,-0.022378717,-0.016148677,-0.00881312,0.029395895,-0.046581037,-0.05743264,-0.13027439,0.14308944,-0.021456772,0.035660617,0.0369658,0.018863814,0.03121114,0.006141301,0.124418736,-0.002343348,0.036846105,-0.02091302,0.019398201,-0.049745064,0.091556914,0.061269723,-0.03790133,0.022334924,0.037614323,0.07675233,-0.033859342,-0.053942867,-0.014028458,-0.02855869,-0.020084161,-0.0140307,0.06212408,-0.018900597,-0.02577199,0.021735664,0.056525666,0.004993509,0.043853793,-0.05212905,0.12921079,-0.043725695,0.04325819,-0.032664705,0.041102592,-0.00988057,0.023977127,0.041690554,-0.055624202,-0.006537628,0.031134518,0.08565568,0.03647658,0.0012246268,0.030899191,0.04388506,-0.040098812,-0.019599712,-0.059180778,-0.05967147,0.015912134,0.028292121,0.04936523,-0.032277327,0.0018409187,-0.046643507,-0.043462534,0.017856233,0.022863977,0.013564998,-0.008275312,-0.061633017,-0.10677404,-0.043655932,-0.01222982,0.0009661791,-0.055517253,0.026183557,0.0037038878,0.041225772,-0.02974349,-0.025992617,-0.056500282,0.09695327,0.107370935,-0.0036701146,0.00484512,-0.022644276,0.000149895,-0.037954014,0.030407978,0.051359598,-2.3889914e-08,0.05065385,-0.09662361,-0.0018386124,-0.09586361,-0.010156769,0.08826081,-0.014498708,0.008432874,0.05027856,0.031845402,0.0578084,-0.0013736965,-0.022005131,0.008030379,-0.02494436,0.0053197583,-0.07938254,-0.012368413,0.047581047,-0.0049085896,-0.12371152,0.07150352,-0.059842825,0.022953507,0.007428185,-0.004864555,-0.017118178,0.14754586,-0.0010690984,-0.105654895,0.06289098,-0.019202802,0.074279934,-0.03343698,-0.07167686,0.027646169,0.061410714,0.018575562,0.009729663,0.0022218213,0.016110763,-0.05591608,-0.08191196,0.0077999732,-0.06954799,-0.05618132,-0.061579525,0.053622503,0.020137148,-0.004037633,0.039480407,0.03310953,0.031598654,-0.06942132,0.0015680373,-0.04009158,-0.027251229,-0.02047199,-0.090730175,0.019830208,0.030445566,0.0006675606,0.09153481,-0.10303002 +2.1.1.177,YbeA does not methylate uridine at position 1915 [1].,384,1.0,0.012439368,-0.03214948,-0.08749517,-0.070663996,-0.025398944,-0.017555479,-0.09198838,0.061449923,0.0013861142,-0.06353197,0.03998974,0.026713824,-0.061177496,-0.0012418639,0.03200589,0.08306656,0.042438768,0.020646993,0.050759673,-0.0036249263,0.09057122,0.06373236,0.07981813,-0.021347305,-0.04518814,0.03905795,0.017704753,0.02194337,-0.02637779,-0.09454974,0.015618334,0.08393124,-0.11277465,-0.03790709,0.047426447,-0.0228654,-0.006061521,-0.008521923,0.05197241,0.009490273,0.022748178,-0.047302663,-0.012771058,-0.016334642,-0.05308275,-0.028729869,-0.03738298,-0.0011720823,-0.042454816,-0.04787262,-0.04624609,-0.062645994,-0.0030377086,0.060961958,0.015183237,-0.0152133675,-0.030072229,-0.031791437,0.022107657,0.020672912,-0.015915815,0.03749696,0.026467377,-0.01842192,0.02967412,-0.053688128,0.008426623,-0.06764677,-0.021958614,-0.03561546,-0.018236889,-0.029184321,0.0015651793,0.07266737,-0.044122506,0.055153098,0.0032510343,0.1066437,0.040005863,-0.036350526,-0.061027866,-0.02474984,0.11652935,0.05898384,0.045885738,-0.038614463,-0.08349332,0.022178402,-0.016475836,0.038933262,0.08920668,0.07865859,0.028143125,0.005360302,0.034349423,-0.009397903,0.043654446,0.03315732,-0.023328794,-0.023084907,-0.0005858506,0.027874716,-0.11702012,0.016026972,-0.019558463,0.009795588,0.08978667,0.04800932,0.0003869643,-0.018564226,-0.07926458,0.0012817594,0.054436803,0.057114672,-0.10830832,-0.06419803,0.08211662,0.07597196,-0.06900021,-0.12947005,0.0054882974,0.008912343,0.021017794,-0.03706648,-0.09917405,-0.02839575,-0.02531756,-2.4204882e-34,0.1336609,0.01105223,0.012638813,-0.07267855,-0.011362191,0.0525957,-0.012609826,0.0020595691,0.072446845,-0.109178066,-0.10414655,-0.08016755,-0.03875492,-0.01957854,-0.06432158,0.015728112,-0.022334918,0.0031659594,0.060401075,-0.09020128,0.04252382,0.05749581,-0.012909761,-0.008695605,-0.100979604,0.061401114,0.055648267,-0.0810734,-0.08351399,0.013187558,-0.0051660854,-0.027373698,-0.038182434,0.015638035,0.053867258,0.043854855,0.0006703996,0.014257462,-0.03935433,0.0088666,0.012921442,0.055863973,0.03429926,-0.06676459,0.051665574,-0.03372173,-0.032326635,0.0711003,0.0035449278,0.12545955,-0.08952337,0.022949867,-0.033085313,-0.012603299,-0.060986213,-0.010030748,0.035952426,0.060113706,-0.057855934,-0.017269468,-0.05020744,0.07209672,0.018267376,-0.040584847,-0.06421781,0.020116847,-0.03837922,-0.08245634,-0.042077444,0.0100041665,0.013968077,0.018423114,0.079252765,-0.0009007039,0.064767495,-0.10651308,-0.026167938,-0.014493154,0.06926046,-0.041396998,0.0529377,0.012646281,-0.015919555,0.03334637,0.031112501,-0.030777289,0.011037957,0.058695335,-0.05897263,0.022408877,0.061455555,-0.061131876,-0.025609406,-0.0033323723,0.027858092,-8.893635e-34,0.010589417,-0.023695769,0.098327026,0.012748863,0.05240158,-0.03525295,0.026233383,-0.0061393953,-0.015085094,-0.09290613,0.12866898,0.0091248015,6.2970714e-05,-0.016283574,-0.004076598,0.03348512,-0.036649093,0.014182727,-0.07965199,-0.016001595,0.00045038247,0.015442665,-0.0047465987,0.09206124,0.030414902,0.013799875,0.05507728,0.00947248,0.030008756,-0.040726334,0.0659145,0.03330682,-0.11303134,-0.088221796,0.015896313,0.03646566,-0.06259325,-0.029761171,-0.053781994,-0.03204683,0.033150554,-0.019458504,-0.06813673,0.030510256,-0.0030288468,0.01152096,-0.029128283,-0.050196886,0.053891204,0.009837649,0.030288627,0.0019990236,0.01315514,0.023283154,0.060776934,0.014932198,0.0040237643,0.008740319,-0.13162366,0.033308763,0.023072055,0.10121621,0.006556364,-0.054509718,0.039045405,0.027629102,0.045999736,0.089923665,0.100409284,-0.033694424,0.15680286,-0.005599599,0.0152129475,-0.030073443,0.013953799,-0.09723937,-0.080920435,-0.05891378,-0.07702206,-0.017786585,0.007911835,0.061877985,0.0030152053,-0.075568356,0.045669686,0.016107509,0.045325983,0.054486245,-0.07027957,0.049822573,0.065261655,-0.014889061,-0.06561018,0.13819447,0.06450289,-1.9233882e-08,0.0141828125,-0.031178843,0.045193966,0.025100086,-0.0019991347,0.04153019,0.012513918,0.009040112,0.0010799902,0.01477398,0.061064605,0.045957267,-0.0035024863,0.07204121,0.03889299,-0.06847759,-0.013879063,0.030619454,-0.0007902435,-0.07888298,-0.039809894,-0.015219712,-0.0252862,-0.014161425,0.0350745,-0.0002037393,-0.038611308,-0.008446182,0.06726151,-0.07952614,0.08996698,0.052854676,0.03652439,-0.028936867,-0.062904514,0.0033670843,0.08212153,0.046791967,-0.020285042,-0.048373085,-0.033454154,0.006100007,-0.043253396,0.07050666,0.044015132,-0.0336436,-0.027277293,0.05156339,-0.061972216,-0.03712955,0.016575513,0.037259877,0.017951239,-0.038670514,-0.07589505,0.03772966,-0.03822826,0.009701109,-0.010828536,-0.039522287,0.07858109,-0.096476726,0.036357768,0.0038656783 +2.1.1.178,The enzyme specifically methylates cytosine1407 at C5 in 16S rRNA. 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+2.1.1.179,"The enzyme from the antibiotic-producing bacterium Micromonospora zionensis specifically methylates guanine1405 at N7 in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins [2]. 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+2.1.1.180,The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position adenine1408 [4]. 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+2.1.1.181,"The recombinant YbiN protein is able to methylate partially deproteinized 50 S ribosomal subunit, but neither the completely assembled 50 S subunits nor completely deproteinized 23 S rRNA [1]. 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Strains lacking the methylase are resistant to kasugamycin 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+2.1.1.183,DIM1 is involved in pre-rRNA processing [1]. 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+2.1.1.184,ErmC is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalysing the methylation of 23S rRNA at adenine2085.,384,1.0,-0.03573646,-0.015555635,-0.09167947,-0.0076693576,0.038306903,0.01842015,-0.015458463,0.08688242,0.054617066,0.0024269898,0.033850588,-0.050479468,0.02756985,0.007398567,0.019269101,0.00044445752,-0.05187328,0.06237704,0.025881568,-0.0083273435,0.005415721,0.072996974,0.043292776,0.08728193,-0.055081595,0.022293909,0.055186134,0.00014924312,-0.047044177,-0.06311449,0.05220957,-0.064848006,0.057586845,-0.0040566837,0.021640617,0.050691634,-0.060064398,-0.02195306,0.06958129,-0.01630974,-0.0016050285,0.011720161,0.0959969,-0.00019791297,0.031918988,-0.041563567,-0.022370102,-0.01694075,0.013742661,-0.0053744265,0.05710719,-0.04865179,-0.07790081,0.0091984235,0.08025896,0.027114933,-0.09335629,-0.06809899,0.032071143,-0.03364272,0.074807905,-0.031759437,0.025142219,-0.06704123,-0.08510251,0.0121187605,0.115381464,-0.03724532,0.08010662,0.03649213,-0.08082071,-0.060232487,-0.018683556,0.10768955,0.05064103,-0.0081234835,-0.011505234,0.028726695,-0.02148593,-0.046403944,0.028372455,0.027142245,0.043219414,0.054296717,-0.0006769708,0.0117209,0.031231927,0.06716275,0.059753597,0.010126597,0.03495682,-0.008468867,0.011079999,-0.03420179,-0.05388264,-0.07835298,-0.044426482,-0.017932525,0.04659034,-0.004211918,0.04124883,0.09836293,-0.020651106,-0.017850105,-0.016815946,-0.039077986,0.058690555,-0.0022102573,-0.012972928,-0.060543783,0.022714052,0.030986782,0.02904536,-0.007316152,-0.03235706,0.015470482,0.062422246,-0.074206196,-0.077517085,0.08470879,-0.013896258,-0.021050235,0.019424234,0.01966521,-0.00072926114,-0.09247902,-0.09381357,4.560076e-33,-0.005987371,0.009712869,0.01671857,0.009420243,0.017899098,0.072871536,-0.033339713,-0.08545135,-0.043965377,-0.08714261,-0.12665021,-0.071018405,0.03702804,0.055310097,-0.011589328,0.032823686,-0.034385655,0.046278592,0.011518208,-0.09157799,-0.027167436,0.025510326,-0.025903994,-0.110038295,0.014989654,0.07036675,-0.022273667,0.024404764,0.12632646,-0.010950287,-0.03696166,-0.080691874,-0.06541818,0.042945698,0.057489432,0.0036725148,-0.034564577,-0.0053589186,0.111542195,0.035047453,-0.074930936,0.07373981,-0.03653364,-0.010544641,0.026880862,-0.016210828,-0.0003038917,0.068962224,0.04935822,0.04477434,0.05989637,-0.120430104,-0.00653945,-0.008682598,-0.046828356,-0.02926151,-0.02436067,0.023366129,0.01114739,0.089289956,0.11719288,-0.020174341,-0.017409422,-0.035019062,0.015387155,0.032907747,-0.010309649,-0.033236604,0.016543513,0.0064215655,0.03790283,-0.09441984,0.13337882,-0.003707242,-0.026980795,0.015072595,-0.12223012,0.017081063,0.054651335,0.062401745,-0.105509765,0.0056322217,-0.081563786,-0.00094429735,-0.035006717,0.04266008,0.026654445,-0.036270943,-0.015116168,0.0658636,0.035411593,-0.15240164,-0.045120582,-0.0042714444,0.021564446,-4.377049e-33,0.020681646,-0.022048948,-0.027248852,-0.030698167,0.02496827,-0.04388467,0.047979802,0.0024552504,-0.025852365,-0.011954118,0.12445839,-0.016123703,-0.015272949,0.011491691,0.025022842,-0.058796395,0.010110108,0.0049923817,-0.025582794,-0.007684024,0.022610344,-0.045090027,0.0089223245,0.042954326,-0.039458286,0.11635801,0.0025277538,0.04263119,0.035558213,0.008409246,-0.10975919,-0.010786143,-0.1102671,-0.060994674,-0.019724555,0.09226575,-0.014551732,0.026933052,-0.065260254,-0.12708436,0.0074326475,0.034115378,-0.056958616,0.02271202,0.023387523,0.11662172,0.019416409,0.02449807,0.044155102,-0.07923232,-0.0076922313,0.043252625,0.054325283,0.048691478,-0.068447284,-0.012027657,0.014927292,0.0003123265,-0.046767257,0.03365527,-0.08640427,-0.0362202,0.019709887,0.008442906,0.0020025407,0.062746756,-0.013497132,0.04386489,0.09408485,-0.029125042,0.08385119,0.01262541,0.02417579,-0.020184005,-0.041034654,-0.0473455,-0.03357599,-0.09363607,0.010717744,-0.026513638,0.029473033,-0.04155889,-0.03472232,0.040439464,-0.079072215,-0.06675155,0.050030697,0.008619618,-0.007908253,0.014946267,0.025147228,-0.024585282,-0.023277655,0.09170697,-0.011893862,-3.1437196e-08,0.0036150934,-0.06621944,0.019574817,-0.03815077,0.009345507,0.04844051,-0.11512936,0.030823888,-0.010660204,0.031304143,0.06413258,-0.009405961,-0.03258983,0.010820353,-0.0046977033,0.050541762,-0.011389859,0.05504833,-0.005881962,-0.1366586,-0.093867734,0.026450384,-0.017139226,-0.015262474,0.053677764,0.010177154,0.00011026735,0.050597243,0.023007438,-0.07328418,0.10712949,-0.013030635,-0.010516638,0.10022386,-0.032826457,-0.009525976,0.017591016,0.006359263,0.031831812,-0.02979602,-0.033627555,0.003460149,-0.07714426,0.044335432,-0.012431721,0.06198353,-0.019433726,0.028529758,-0.014833651,-0.047381118,0.04688431,-0.049672358,0.01320249,-0.002713354,-0.12375266,-0.022918995,-0.041173123,-0.028265882,0.036605466,0.048146673,-0.0016639418,-0.041531265,0.11652189,0.012457261 +2.1.1.185,"The enzyme catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA.",384,1.0,-0.09297937,-0.024829917,-0.1306517,-0.0675248,0.02930601,0.04918217,-0.058935516,-0.02014088,-0.017347574,0.011614182,0.031661246,-0.050487787,0.015921459,-0.0018582833,0.020763755,0.0112110535,-0.13795048,0.016636021,-0.0029375071,-0.063327126,0.057171095,0.057475645,-0.02606011,-0.0062147714,-0.010559581,0.058867,0.036548384,-0.07171332,0.0019213634,-0.03194646,0.04062524,-0.034359097,-0.031953745,-0.017519679,0.01719347,0.05736354,-0.101913266,-0.007537147,0.113148324,-0.007488117,0.015281553,0.006512241,0.022495568,0.024258303,0.027209481,-0.0019670746,0.075143375,0.012159165,-0.062642604,-0.006863776,-0.037872873,-0.039618626,-0.030232972,0.0003224863,0.054867428,0.032931786,0.010284355,-0.015485607,-0.012414954,-0.007666164,0.08782679,-0.06805998,-0.026436236,-0.07628782,-0.057509754,-0.028514491,0.054684076,-0.0227994,0.048258428,-0.03202207,-0.024475046,-0.017131485,-0.076075405,0.030429477,-0.03264052,0.050148215,0.050964482,-0.017080987,-0.001729307,0.016644206,0.05010957,0.022265194,0.091885716,-0.009334184,0.08452657,-0.01481287,0.0162127,0.03900079,0.07524823,0.02121499,0.0030509257,-0.034221243,0.0033624533,-0.007586893,-0.10795347,0.020615289,-0.012047937,-0.043004006,0.006275295,0.003253031,0.03543917,0.06460573,-0.057820514,-0.024890287,-0.030124752,0.05194964,0.060460214,0.10931795,-0.058745664,0.021144327,0.02431958,0.08811588,0.023130873,0.020669777,0.012984428,0.09485581,-0.025590584,-0.0104388315,0.023951706,0.008480748,-0.055728808,0.057605132,-0.027473526,0.005798599,-0.10865404,-0.0009845314,-0.122439325,2.2213085e-33,-0.017921828,0.0426849,-0.03870266,0.021444798,0.05144298,0.10421738,-0.058441464,-0.002063384,-0.00044190823,-0.04093939,-0.057582483,-0.10073907,-0.0031489674,-3.20844e-05,-0.06380682,0.064362004,-0.06181002,-0.01909406,-0.003829207,-0.077939056,-0.040843066,0.060828462,-0.06708771,-0.082578436,0.0046194885,0.019386612,0.007631014,-0.028238999,0.087524645,-0.019939998,-0.07591547,-0.036651958,-0.05240539,0.037085347,0.09861175,-0.012226241,0.0335164,0.013900359,0.037049666,0.043638296,-0.007654018,0.041385435,-0.032871373,-0.012674262,0.009865623,0.0033624999,0.034109883,0.118917294,-0.008193375,0.016803855,0.0028848734,-0.012205063,0.05570506,0.043403532,-0.062303178,-0.056435365,-0.01706082,-0.048774157,-0.020221557,-0.007390687,0.06242336,-0.035299294,0.11412757,-0.005678324,0.03416222,0.0021766168,-0.06443784,-0.06253723,0.06406595,0.13981248,-0.013939951,-0.009843956,0.11193804,-0.057626035,0.041539468,-0.061319422,-0.030567067,-0.006078511,0.062492423,0.074047215,-0.012455234,0.049275342,-0.012549369,-0.04041999,-0.033511415,-0.004846657,-0.008168439,-0.048793554,0.021227283,0.080124356,0.025788791,-0.04599616,-0.018129816,0.052084554,0.008729712,-1.6395347e-33,0.08964993,-0.044490416,0.047350936,-0.07616662,-0.085192434,-0.009231123,0.006471728,-0.08071815,-0.047836233,-0.07737813,0.09044527,-0.002461706,0.0040790318,-0.0016839827,0.07928659,-0.074538946,0.047845207,0.0637596,-0.04834616,-0.027372885,0.023548625,0.050027557,-0.06149396,0.06391355,0.001920506,0.03415576,-0.013435796,0.04756571,0.11968345,0.01097563,-0.09188069,-0.01835809,-0.06686844,-0.016934581,-0.03493144,0.069269165,0.012398945,0.048915192,-0.055561885,-0.0061482606,0.015346948,0.011391813,-0.032905754,0.14345138,-0.013578278,0.1082712,0.0003175129,0.018432576,-0.053760786,-0.056276683,0.0337864,-0.05618924,-0.030457934,0.008735085,0.052818924,-0.014977177,-0.025639225,-0.011466573,0.020654738,-0.033075534,-0.012676664,-0.02590525,-0.08838388,-0.040936474,0.022412553,0.065456904,0.017646505,0.065171264,0.093592264,0.045394197,0.0044754655,0.006553759,0.017815912,0.01784937,-0.022406569,-0.041783318,-0.052239507,-0.07256403,-0.03955773,-0.11625317,0.04051817,-0.019311614,-0.021561254,-0.058405288,-0.019325534,-0.07834291,0.03998763,0.12648374,0.03423101,0.053378884,-0.050524738,0.03904199,-0.041328274,0.06933624,0.050710786,-2.6246546e-08,-0.008095421,-0.025037525,-0.041519385,0.053277504,-0.069639675,0.12717001,-0.05472943,0.058449525,0.054575864,0.02090511,0.007138288,-0.014945603,0.0017414772,0.075216725,-0.02135015,0.04647873,-0.03760238,0.04757799,0.040615406,-0.025527978,-0.10637227,0.05444846,-0.083503485,0.02630924,-0.04400506,-0.028581098,0.010417618,0.0846897,0.027250292,-0.06741816,0.058050573,-0.024518106,0.03732284,0.03640495,0.003639578,0.017346019,0.05531701,-0.032531735,0.043481372,-0.07486009,0.010261368,0.01300695,-0.09818223,0.046327543,-0.06320087,-0.04478512,-0.021237493,0.042548396,0.015181531,0.06258305,-0.003836088,0.034910336,0.038160536,-0.01042708,-0.079482585,-0.03430614,-0.04697253,-0.033623755,-0.056036964,0.03614158,0.039251976,-0.046502326,0.07747562,-0.09764051 +2.5.1.81,"The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate [1]. The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. The enzyme is involved in the biosynthesis of C25-C25 membrane lipids [2]. ",384,1.0,-0.0363917,0.022625001,-0.061304852,-0.014043675,-0.024308441,0.0332648,-0.057569142,-0.021648072,0.0045623137,-0.041585244,-0.06747438,-0.051316082,-0.027512876,0.0025018211,-0.040231086,0.104410045,-0.030886775,-0.0022640813,-0.0062935166,-0.02445159,0.07074151,-0.039127424,-0.010395589,-0.0611808,-0.003474937,-0.074739195,0.027649855,0.012624908,0.026301332,-0.0407296,-0.0015967652,0.022717042,-0.0447438,-0.07055375,0.075669974,0.094566636,-0.031963564,-0.014264658,0.059299298,0.0032958072,0.08210102,0.032943215,-0.028648278,0.017622849,-0.04577409,-0.059006196,-0.013417367,0.04624314,0.027227787,-0.0866016,-0.100073695,-0.061906468,0.011990562,-0.029866515,0.021444535,0.042641666,-0.00020933292,-0.03389466,-0.011700075,-0.004479362,0.0077404818,0.009605298,-0.011448906,-0.047965623,-0.022941304,-0.10442311,-0.0031166421,-0.022921933,0.1417004,-0.052464347,-0.068287425,-0.00883655,-0.015860258,-0.044931855,-0.06381121,-0.044851165,-0.006621674,-0.030111639,0.034935158,-0.06491079,-0.0045022625,0.0055695144,0.031628888,0.034837466,0.11126332,0.017396154,0.009559402,0.030829983,0.017353129,0.002883916,-0.0063122488,-0.07775234,-0.03717145,-0.027196368,-0.07051183,-0.02305097,0.071944766,-0.023571879,-0.037999716,0.0029731703,0.028116621,-0.042656478,-0.00031175202,-0.058708034,-0.048184518,-0.03417981,0.09731142,0.013751971,0.013377973,0.012818604,-0.059219625,0.017461155,0.06982688,0.03221742,-0.056236744,0.033448253,-0.00464589,-0.07840882,0.06883571,-0.031168591,-0.016407952,-0.039558485,0.044793032,0.01131979,-0.0019080642,-0.028339993,-0.09894346,5.6688836e-33,0.03979562,0.0057674255,-0.015161283,-0.003396684,-0.0029681765,0.01362514,-0.04864799,-0.038643323,0.00019555406,-0.023316868,-0.109784536,-0.1296927,0.0071492223,0.05001277,-0.008034523,-0.045773353,-0.01495195,-0.027739847,0.093989566,-0.022608781,-0.015913213,0.02495231,-0.08895438,-0.017571779,0.058443334,0.0010150454,-0.016433874,0.018613959,0.03602356,0.025732761,0.04261114,-0.05477246,-0.10072741,0.029568374,0.014935884,0.06977796,-0.06685724,-0.04732574,-0.026077412,0.044699427,0.010886326,-0.0076361788,-0.014475133,-0.06522058,0.019322649,0.044049133,-0.11596143,0.09503123,0.08865769,-0.057784807,0.019070582,0.009912617,0.09216996,0.00097541657,-0.103328824,-0.014282573,0.00364121,-0.05543713,0.05956467,0.062336195,-0.016684089,0.009812223,-0.056704685,0.03860422,0.041646436,0.033851303,-0.02868205,-0.014640096,0.030697742,0.07579986,-0.05466407,-0.01447796,0.024549296,0.09093893,0.033987872,-0.010753823,-0.0052562044,0.0045251246,0.109070845,0.0019713708,0.09157737,-0.036474604,0.0026401808,-0.052871637,-0.026895631,0.0041684355,-0.040850654,-0.02137747,0.025570873,0.096803404,0.05219895,-0.121224366,0.017663749,0.09683051,-0.03765684,-7.0266784e-33,-0.013060375,-0.01949089,0.1043209,-0.11165441,-0.022224365,0.11830114,0.0065523894,-0.05239383,0.008960858,0.021990988,0.054245476,-0.0051310332,0.05290114,0.042845257,0.038378872,0.07572017,-0.032895964,0.07145879,0.056310304,-0.04287916,-0.025581533,0.009301443,-0.03530591,-0.0021194962,0.0063446835,-0.009917799,0.03562208,0.03274765,0.015063065,0.03263579,-0.010639473,0.008220339,-0.08054667,0.00035377382,-0.021616543,0.021541638,-0.10482541,-0.008294422,0.028856304,0.003299428,-0.021252705,0.03588766,0.022596687,0.05673695,0.06140737,0.03283706,-0.08256799,-0.08475792,-0.01627198,-0.107565574,0.00714092,-0.0032428263,0.008482442,-0.025975132,0.0036639415,0.08054204,0.047707707,-0.01408999,0.06984765,-0.10400723,-0.06422749,-0.033176806,0.05451503,-0.0094462875,0.028818412,0.08237825,-0.0050666425,0.061410047,-0.01235371,-0.006572796,0.051898737,0.09109672,0.015314884,0.09043614,-0.09212052,0.031103833,-0.07838356,-0.0060840407,0.03079925,0.0020334548,0.061305944,0.009542193,0.0052629593,-0.052653454,-0.04659934,-0.04997313,0.11968908,0.05898033,0.044650257,0.031235708,0.03638662,0.02555045,-0.070427105,0.038017265,0.09817492,-4.2407255e-08,0.01391546,-0.09586863,0.035387874,-0.037291314,-0.091056846,0.018467389,0.07731994,0.014419818,0.016256081,-0.0062312405,-0.03622735,0.08555816,0.018004384,0.050874252,-0.028679213,0.055164535,-0.052005038,0.0014686052,0.036648016,0.03600379,-0.033721317,0.011638292,-0.048202667,0.0692148,-0.018143672,-0.08216541,0.035059474,0.07459212,0.007367117,-0.0968438,-0.025710318,0.044748105,-0.002444303,-0.0047602905,-0.1246102,0.061982207,-0.02741203,-0.063337095,-0.040362578,0.046541333,0.1040765,-0.06530653,0.039768875,-0.0066432757,0.05302107,-0.06174119,-0.040903818,-1.5013514e-06,-0.035899103,-0.036521215,0.057816826,0.02998489,0.05772914,-0.036576826,-0.061074395,-0.024765009,-0.14099005,-0.002572062,-0.009230383,-0.012800789,0.012579451,0.07244861,0.14622152,-0.027263824 +2.5.1.82,The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate. Requires Mg2+ [1]. ,384,0.99999994,-0.04929735,-0.073008776,-0.0040706736,-0.034084085,0.022754064,-0.03866328,-0.060890745,0.026998363,-0.006697577,-0.050505005,0.022042535,0.015935423,-0.0008456502,0.05745676,0.04726828,0.008450484,0.034461122,0.02683889,0.044270918,0.006842,0.071487375,-0.03693108,0.025200717,-0.027666362,0.06906379,-0.02287943,0.12081253,0.0046340507,0.05347237,-0.025751742,-0.0730148,0.018644305,0.013255014,-0.053116925,0.044905607,0.14694263,-0.02369623,-0.022280158,-0.0109948525,0.008978187,0.047013495,-0.0050683436,0.079467565,-0.020292291,-0.043044813,-0.08154484,0.010421767,-0.033032175,-0.017281054,0.03394328,-0.074505925,-0.019258032,-0.02011026,-0.07799833,0.019494854,-0.028875541,-0.12414865,-0.020518282,-0.041480284,0.023555152,0.00042231183,0.006017516,-0.07156753,-0.07967221,0.042120937,-0.02491753,0.08853461,-0.025482494,0.05664266,-0.03943575,-0.08703596,0.0043004993,-0.024847038,0.013216843,-0.07824943,0.046073258,0.02732559,-0.007869709,0.049962282,-0.07765022,0.006137363,-0.021657612,0.013259467,0.0284253,0.055120695,0.028721843,-0.026320182,0.08819871,0.070103996,0.05245008,0.09725168,0.037916247,-0.045000963,-0.020969177,-0.030238947,0.04297899,-0.06481607,0.0037456471,-0.07219277,0.0062112007,0.09370834,0.05642428,-0.0041651153,0.0039984444,-0.0049744076,0.03062993,-0.027732542,0.027438844,-0.0012145059,-0.014689628,0.051548373,0.04760371,0.07421443,0.027326854,-0.06109753,0.038746838,-0.0055482145,-0.10002862,-0.058486957,0.034070946,-0.034754705,0.0065789036,0.002495245,0.077940375,0.013206359,-0.0041208486,-0.08406381,6.0126687e-33,0.017894952,0.027069371,0.05382428,-0.051160473,-0.0998152,0.05725704,-0.0770791,0.040722758,-0.08474581,-0.0042509693,-0.03521087,-0.059520815,0.04255974,0.0102303745,-0.013165797,-0.013375652,0.022554189,0.03153198,0.114237964,-0.030067263,-0.0039987387,0.048979938,-0.019096024,-0.013341171,0.008651947,0.061979596,-0.028409112,-0.027468717,0.06228712,0.01815606,0.075854495,-0.16539077,-0.041049402,0.007988207,0.011114534,-0.05634935,-0.057175726,-0.06593392,-0.04581816,-0.016821317,-0.046971824,0.016576188,-0.053815603,0.01956668,0.041084617,-0.10774358,0.003790748,0.08326246,0.00836012,0.030824073,0.07100887,-0.00334378,0.005182431,0.013512009,-0.08488482,0.054724596,-0.021143219,0.020188749,0.07397907,0.0024815246,0.0085785445,0.014542307,-0.021304535,-0.011040567,0.072627634,0.029235236,-0.06405999,-0.049571544,-0.0117850555,0.17550346,0.011164428,-0.06500088,0.0031198927,0.113266006,-0.026234142,-0.029141461,-0.03368495,0.011627349,0.08734263,-0.020465264,0.02168369,-0.05921937,-0.009155703,-0.01731256,-0.099986106,0.006552642,-0.00027434202,-0.07222318,-0.004000997,0.07986779,0.06358456,-0.057721943,-0.021802818,0.053196233,-0.0073472103,-6.042253e-33,0.08596437,-0.04337851,0.009284355,-0.08453127,-0.07587054,0.009909048,0.10135134,-0.09263507,-0.008702585,0.00015127147,0.07788431,-0.0220771,0.003850785,-0.059648365,0.012269961,0.028641552,-0.013709205,0.07046192,0.041937586,-0.01105114,-0.04512182,0.10811985,0.076783806,0.0880791,0.004074022,0.015818497,0.02658767,0.020304406,-0.0179048,0.10607539,-0.003929886,0.0774799,-0.049709134,-0.09610987,-0.06820913,0.03649295,-0.06559585,0.01522699,0.029986592,0.023012102,-0.0292632,0.06695875,0.025272224,0.06314741,-0.0054620677,0.05699992,0.013008589,-0.029769255,0.025346853,-0.11482443,-0.029166548,0.06048911,-0.014033446,-0.014107107,0.021106957,0.015298786,-0.025287952,-0.051085558,-0.0024427644,-0.061988562,-0.055564508,-0.06072519,0.0208614,-0.11129597,0.072306015,0.10748231,0.016666614,0.08538268,0.051583786,0.03564414,0.026630912,0.03524723,0.07241792,0.0249139,-0.041475803,0.111904696,-0.009746789,-0.024313254,0.048867546,-0.08896134,0.02728341,0.063507386,-0.0510385,-0.014029087,-0.052933592,-0.096310064,0.02922031,0.09276262,0.065860994,0.00276781,-0.03564837,-0.015377627,0.00073905615,-2.9544559e-05,0.090195276,-3.457323e-08,-0.03437537,-0.060041476,0.060824826,-0.022705223,-0.04122399,0.082588956,-0.017100621,-0.02256771,-0.003896108,0.035453696,-0.026809676,-0.0037350666,-0.04219875,0.0025916712,0.053648345,-0.032028027,-0.041901898,0.035646807,-0.0681893,-0.07439627,-0.036611572,-0.010185592,-0.07984396,0.049189933,0.013396537,-0.058505077,0.0009323186,0.04978476,0.019169237,-0.046850823,0.015133208,-0.0013431604,-0.018895125,0.0096867,-0.07245586,0.039268345,-0.043784942,0.031156113,-0.07514431,-0.014702643,-0.027588619,-0.053939898,-0.031238548,0.022918174,-0.051326696,0.00653282,0.072650276,0.0045548193,-0.013107325,0.029981688,0.08070101,-0.04281468,-0.032152716,-0.022365348,-0.017538523,-0.03413623,-0.05354742,-0.06495024,-0.028117845,-0.08799637,0.026252225,0.038663648,0.045323707,-0.06694525 +2.5.1.83,The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate [1]. ,384,1.0,-0.029012272,-0.06683733,-0.027649278,-0.05454536,0.033922818,0.025330007,-0.08952218,0.04040024,0.043665837,-0.05817955,0.030255158,0.007948865,-0.053114925,0.07962151,0.028145386,0.017262291,0.0021960917,-0.010374196,0.043059137,-0.014815882,0.037130177,-0.04751972,0.015889924,-0.033608496,0.095564626,-0.041889835,0.11055548,0.0011831659,0.039678082,-0.056565624,-0.101547256,0.006088943,0.016256323,-0.029128227,0.025780082,0.14465435,-0.007231142,-0.04645168,0.020205125,0.03793391,0.042396065,-0.01006577,0.014618668,-0.01662034,-0.06890893,-0.032662824,-0.015624917,-0.0069145462,-0.028924448,0.004156747,-0.07503645,-0.039760455,-0.0041930582,-0.0739875,0.007036562,-0.015980892,-0.09183649,-0.018202353,-0.042509083,0.046525043,0.0061025447,-0.005140718,-0.0359132,-0.06753747,0.037688997,-0.050477948,0.090780295,-0.006294545,0.04489273,-0.055513024,-0.11235452,0.008669134,-0.01981869,0.02027419,-0.049748395,0.044761196,-1.1823285e-05,0.021629876,0.041031092,-0.11568984,0.008066772,-0.010481415,-0.016229302,0.026025862,0.053953014,0.037005693,-0.058494247,0.068294376,0.07573482,0.006578427,0.058289018,-0.0089346925,-0.06461566,-0.05241831,-0.027829885,0.0453652,-0.028967017,-0.01919139,-0.08633796,-0.024557129,0.12033102,0.04672966,0.0054356894,-0.027100977,0.017504074,0.027197365,-0.027414858,0.04634082,-0.0019062434,-0.036805734,0.022145787,0.04719404,0.09685329,-0.013005179,-0.09629126,0.020190177,0.012583314,-0.06808248,-0.06807346,0.03971758,-0.05843253,-0.00785269,0.0207178,0.10161647,0.022465747,-0.0145840645,-0.100131154,5.014575e-33,0.07254304,0.026531288,0.021596186,-0.060720988,-0.07652394,0.030150563,-0.06931012,0.062434718,-0.11751736,-0.0060407463,-0.0055043767,-0.057714943,0.07522468,0.0052149775,-0.011160671,0.024042731,0.010910548,0.01803137,0.078258194,-0.048866164,0.013110091,0.02377093,-0.035718527,0.005787082,0.011766761,0.009043213,-0.047898985,0.016541487,0.039992977,-0.00075037545,0.055801317,-0.14481463,-0.06761359,-0.007684488,0.024948634,-0.0369577,-0.057328496,-0.06423263,-0.04118391,-0.0067538666,-0.0034939707,0.01516297,-0.027628774,-0.028347153,0.05607314,-0.09136643,-0.01802425,0.099335454,0.02463389,4.651894e-05,0.06498839,-0.033842824,0.041690722,0.0013896598,-0.07464571,0.054218747,-0.0019983,-0.0059897155,0.037187636,0.017506415,0.0056336494,0.0031146482,-0.057289284,-0.008580756,0.027396902,0.021755328,-0.05075094,-0.034021553,-0.0071122786,0.1813182,-0.007879283,-0.03809686,-0.01226469,0.10804649,-0.029402323,-0.03761729,-0.05418501,0.0061852015,0.10295562,-0.026282512,0.03795915,-0.08167062,-0.012839165,-0.016564678,-0.09933046,-0.010437651,0.00042076563,-0.077499226,0.0024212864,0.10348905,0.071338974,-0.06748497,-0.017926915,0.042644,-0.001137322,-5.608059e-33,0.09155094,-0.06216888,-0.010336555,-0.086480916,-0.044942405,0.014084004,0.088437036,-0.05641939,-0.020949747,-0.016460698,0.075377345,-0.022138184,0.018321954,-0.046311498,0.007543764,0.082314745,-0.014531447,0.0723378,0.08390975,0.008825772,-0.06425124,0.08422121,0.09085772,0.092828155,-0.0010775322,0.014304444,0.015870016,0.03229682,-0.03749596,0.08821672,-0.009030858,0.023194572,-0.054041646,-0.09017391,-0.0496201,0.023232296,-0.09087241,0.012067104,0.06398268,-0.0091181975,-0.026843453,0.05537519,0.00045123446,0.05469278,0.0024896532,0.060838807,-0.0014262088,-0.06086561,-0.02861766,-0.0957897,-0.00910636,0.08257807,0.015780117,0.016385358,-0.008123925,0.03235914,-0.0098990705,-0.03717095,-0.012083377,-0.043938413,-0.063133694,-0.06748984,0.0070869643,-0.07478316,0.07783253,0.09405163,-0.024653114,0.10965616,0.0560371,-0.00851669,0.01942756,0.031696152,0.056136403,0.033514883,-0.056633282,0.07816463,-0.015177544,-0.029171476,0.0494847,-0.044137668,-0.00014936416,0.05154632,-0.055095416,-0.03387601,-0.05343271,-0.038083035,0.05605506,0.09714882,0.05310079,0.020411132,-0.002395829,0.013248354,0.020808388,-0.015457073,0.12313954,-3.3084632e-08,0.006333462,-0.04928192,0.06411206,-0.013385944,-0.04449374,0.047310017,0.041708168,0.024616139,-0.04072396,0.052687436,-0.052993663,0.046842393,-0.022032687,0.013693176,0.09113534,-0.025489422,-0.048949145,0.038408335,-0.057121713,-0.050079595,-0.032794964,0.02575416,-0.072147995,0.049923893,0.00950843,-0.04818902,0.020252122,0.04696282,0.034046628,-0.05379338,0.024104834,0.0149331605,-0.017280659,0.008225196,-0.0704091,0.05090257,-0.03312058,0.019098222,-0.07496053,0.043625344,-0.0014681768,-0.0358293,-0.09098621,0.024973718,-0.037561588,0.012636241,0.08297209,0.007756668,0.0034041656,0.005049111,0.09114397,-0.025112098,-0.013464165,-0.026941555,-0.046169963,-0.025234288,-0.08745957,-0.053780116,-0.00797455,-0.055484105,0.029513214,0.042335156,0.10234468,-0.05928908 +2.5.1.84,"(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3]. 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The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains [2]. 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+2.5.1.86,"The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan [2]. 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The yeast Saccharomyces cerevisiae has two different enzymes that catalyse this reaction. Rer2p synthesizes a well-defined family of polyprenols of 13--18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits. Largest Srt1p products reach C(290) [2]. The enzyme from Arabidopsis thaliana catalyses the formation of polyprenyl diphosphates with predominant carbon number C(120) [4].",384,1.0,-0.027038205,-0.039738014,-0.006883187,-0.0106382705,0.06024849,0.042044926,-0.09839962,0.06985378,0.07883498,-0.033494506,0.028134381,0.06348016,-0.07969189,-0.02452634,-0.046319105,0.012632607,0.018290987,0.058385324,0.027811607,-0.029117504,0.081666745,-0.074173115,-0.037640125,-0.009034407,0.054746598,-0.030331273,-0.021604137,-0.034212627,0.028702665,-0.027350925,-0.038851622,-0.037946343,-0.00839557,-0.057534568,-0.0052411514,0.123393506,-0.011538626,-0.04760753,0.020450037,0.016966883,0.04754615,-0.06346385,-0.030044863,-0.012983883,-0.073764704,0.011282755,-0.019920649,0.070131026,-7.1237904e-05,-0.054481838,-0.04420407,-0.045444384,0.034585074,-0.049947366,0.061232734,0.06988339,-0.03791283,0.032852463,0.04781261,0.004275428,-0.0050162454,-0.016224684,-0.036938548,-0.016120458,-0.033592444,0.019514943,0.01857077,0.0061919647,0.041428465,0.031421535,-0.0859389,0.060980175,-0.045013126,0.04025192,0.007147728,0.02142706,0.01883653,-0.0034497492,0.030848244,-0.03977543,0.055028483,0.01673649,0.03754766,0.013283245,0.0094726,0.026595427,0.062283825,0.06786854,0.076289915,0.004527193,-0.06266539,-0.017453067,0.028940847,-0.016703302,-0.033541378,0.090794586,-0.0066649937,0.025318699,-0.0100716995,-0.05239874,0.034031965,0.028545795,0.03957286,-0.1064653,-0.0491146,-0.0054001766,-0.06979032,0.0648272,0.04570156,0.0710487,0.020458909,0.055513185,0.029931355,-0.04210672,-0.01937627,0.007429022,0.010645948,-0.019232394,-0.053254887,-0.08923191,-0.009015772,0.017270366,-0.023714216,0.035167065,-0.0306729,-0.031790365,-0.09309173,4.157312e-33,0.05124187,0.06077713,0.013615232,0.023386871,-0.015676435,-0.030882787,-0.0032652514,0.035892602,-0.10568988,-0.017575298,-0.041145276,-0.112548195,-0.03251307,0.058678567,0.045587886,-0.044215385,0.06702041,0.0007060563,0.12070699,-0.06522574,-0.05122357,0.038761254,-0.027970698,-0.03696739,0.030334491,0.0026928068,-0.027845563,-0.00675387,-0.015259485,-0.048185974,0.043919828,-0.05314805,-0.07882465,0.069585234,0.050980862,-0.04999113,-0.016925864,-0.062239483,-0.0058325413,0.05134854,0.00467607,0.09019524,-0.0067475843,-0.06868103,0.0911902,-0.025705831,-0.0064426614,0.078813426,0.10357779,0.08408306,0.037867274,0.05156713,0.014359919,0.020254383,-0.14424425,0.004791146,0.0023948974,-0.018928036,-0.012998885,0.062546976,-0.0703698,0.08500957,0.010993912,-0.008150847,0.022896586,0.05571222,-0.0702864,-0.052254606,0.034862477,0.06524048,-0.022575095,-0.02482016,0.04501703,-0.0049909735,-0.006201037,-0.031157209,-0.039660253,0.034292236,0.07395952,0.0448504,-0.05477451,-0.03213587,0.007468327,-0.049233936,-0.0848014,-0.032929797,0.001156567,-0.10593408,0.0110221645,0.04720957,0.037513167,-0.12747654,-0.001273795,0.079515025,-0.060236514,-5.794417e-33,0.099754885,-0.08693613,0.111183465,-0.04091685,-0.07614554,0.0069228616,-0.0068347,-0.06899702,-0.07417149,-0.04424383,0.05350751,-0.044056736,0.09025888,0.011060121,-0.01752339,-0.023397224,0.0036561994,0.100169905,-0.022544188,-0.01577819,0.01191211,0.074792,0.010451644,0.1241175,0.056337025,0.028085984,0.08905821,0.09160858,-0.036551535,0.008443637,-0.009794677,0.037134,-0.04162129,-0.0136125805,0.01254371,-0.007635165,-0.1441354,0.06813084,0.062461108,0.03103931,-0.034234133,0.056618795,-0.028798664,-0.006291044,0.005305245,0.031240107,-0.043302428,-0.022007441,0.05447442,-0.10314343,-0.03601199,0.016936775,-0.02342524,0.033687875,0.024044583,-0.009448602,-0.0511093,0.04892211,0.031080652,-0.10494319,-0.018233733,-0.080925144,0.043472998,0.012505955,0.08194782,0.06368348,-0.043082666,-0.059655286,-0.023235332,-0.027096601,0.03251347,0.02953098,0.03679547,0.024986474,-0.053914923,-0.047015913,-0.04477327,-0.043389842,-0.076161854,-0.01536611,-0.0010364724,-0.019779598,-0.022079844,-0.06504301,-0.0036547096,-0.03986452,0.087898605,0.107232876,0.0054077213,0.04589039,-0.008138721,0.09285416,-0.026238538,0.06467582,0.17514145,-4.433838e-08,-0.010554103,0.01384098,0.03986159,-0.042303495,-0.04897599,0.016636338,0.015801655,-0.012119398,-0.026710784,0.06432891,-0.12486093,0.054375798,0.007959694,-0.016378745,0.021011332,-0.01435126,-0.10201425,-0.025000762,-0.012364731,-0.020798035,-0.054754905,-0.034930862,-0.06958155,0.03652379,0.020867314,-0.13169837,0.027156252,0.037428077,0.03556539,-0.0026960305,0.014324145,-0.0039016204,0.01398935,-0.004197669,0.02781745,0.057169173,-0.021593692,-0.024193196,0.0007353176,0.018613111,-0.009193612,-0.060574967,0.0076943436,0.048639257,-0.052273437,-0.039339367,0.01757549,0.0025237028,-0.020722104,0.001073977,0.077014,-0.013226339,-0.0376742,-0.09245193,-0.017064564,0.008471137,-0.088745736,0.057954717,-0.038609564,0.007571853,0.008258263,-0.060100954,0.1196935,-0.06431473 +2.5.1.88,"Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1]. 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Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate [1].",384,0.99999994,-0.09504643,-0.01907917,-0.10544993,-0.06180676,-0.039010134,-0.015720053,-0.06454652,0.042551856,0.05190524,-0.0462451,0.07284718,-0.0549214,-0.08200928,-0.003034884,-0.032326818,-0.044319175,-0.015396116,-0.026466718,-0.0012267142,-0.06449718,0.08617799,0.02928754,-0.004992196,-0.010912924,-0.02183471,-0.0022586137,0.077334054,-0.05299639,0.045260847,-0.110242486,-0.022592263,-0.013995865,0.033847194,-0.07620525,0.06620375,0.1006308,-0.00040569672,-0.023869116,0.07900638,0.07842415,0.057930548,-0.04069661,0.009742054,-0.019503292,-0.016227163,-0.04063736,-0.03408604,0.07060096,0.040567093,0.0043461327,-0.0103518665,-0.04633756,0.026294762,-0.061685406,0.017077683,0.020465981,-0.04790859,-0.07814354,-0.013977688,0.0038717831,0.097501285,0.028372688,0.017683413,-0.0012883075,-0.06881002,-0.09672287,0.10365652,-0.07183908,0.038779777,-0.034865275,-0.115110934,-0.024351398,-0.079905145,0.024282172,-0.06723691,0.02240293,0.028079433,-0.018475505,0.029468149,-0.05981278,0.06104477,-0.04583738,0.0031869158,0.051505953,0.016680466,-0.07227447,-0.024271123,0.050245594,0.02706983,0.008057969,0.034715824,-0.022342531,0.05907156,-0.030060686,-0.06858235,0.061219126,0.0071652564,0.014595175,-0.044425134,-0.028821092,0.027479822,0.04609409,-0.0074359216,-0.05869648,-0.035805587,-0.021247381,-0.00642671,0.051214565,0.07891991,-0.010294119,-0.037075598,0.024697786,0.03923632,-0.02189673,-0.0864957,0.07438832,0.007279325,-0.078846805,-0.0129229445,0.015512486,-0.011510494,-0.08310562,-0.0062378775,0.061336875,-0.019990755,0.010232604,-0.10396621,4.199697e-33,0.094451964,0.058815826,-0.03605921,-0.043461222,-0.040805332,0.011904479,-0.07011902,-0.03820046,-0.11573195,-0.038924407,-0.05288089,-0.111052245,0.03699534,0.099645354,0.01725731,0.050227117,-0.011180979,0.035549592,0.091077246,0.0058207256,0.024545724,0.088918366,-0.019691668,-0.045197397,0.108227074,0.05670308,-0.030041967,-0.013773975,0.04463402,0.0033202642,0.07361136,-0.15220913,-0.04716945,0.04468326,0.12200666,-0.051533002,-0.019379932,-0.053340506,-0.040489603,0.03838464,-0.0035965613,0.022452412,0.005906566,-0.016759438,0.034516804,-0.028817983,-0.015606197,0.07240953,0.07198275,0.019233653,0.03404841,0.04105459,0.073609,0.029963462,-0.053666834,0.009315389,-0.03641503,0.008768103,0.018059433,-0.0020316818,0.011628323,0.10551505,-0.061469737,0.0069310036,0.021140106,0.030354025,-0.062363867,-0.038381156,0.035205547,0.103814885,0.0003711888,-0.029979154,0.0077614756,0.09995681,-0.00552875,-0.032811664,-0.03592723,0.0012165343,0.07046077,-0.0026613178,0.009462276,-0.042954806,0.05086619,-0.05050086,-0.06324087,0.008155371,-0.041276928,-0.036982838,0.031024778,0.07431297,0.04152959,-0.03426269,-0.0613573,0.05584826,-0.04233095,-5.3244946e-33,0.06386367,-0.07735319,-0.030101709,-0.086515,-0.059648182,0.06804733,0.0006438316,-0.0013660773,0.0074186367,-0.0011154459,0.058969077,0.026826752,0.06278351,-0.02529693,0.026190607,0.060405534,0.009127563,0.021649621,-0.013836492,-0.05958051,0.04621863,0.00065963244,0.051224977,0.024606457,0.0024981825,0.0051001734,-0.0028173293,0.05013505,-0.08066183,0.03833638,-0.034671817,0.0014665507,-0.04646473,-0.08367727,-0.054490216,0.014079291,-0.08504755,0.028302254,0.029986287,-0.02728103,-0.0495892,0.05326474,0.05088568,0.055518568,0.03276301,0.036161225,-0.011952151,-0.02669641,-0.016640497,-0.047908843,-0.022337379,0.047446925,0.07429056,0.08361705,0.041479763,-0.0014536815,0.0051676407,0.04447433,0.012698613,-0.028699553,-0.041323423,-0.11973407,0.028674843,-0.06536551,0.09866174,0.1440958,-0.02237867,0.069594786,0.009013039,0.009849658,0.065029226,0.021956997,-0.0013868023,0.03544344,-0.043908905,0.037466913,-0.037453014,-0.098245524,0.018245747,-0.022417873,0.04054657,-0.026324721,0.012412027,-0.08727451,-0.014421281,-0.079619825,0.09319656,0.12040739,-0.00718358,0.023236454,-0.008702264,-0.04304518,-0.071514085,-0.0057016085,0.07715058,-4.127819e-08,-0.0048054974,-0.039505515,0.016054204,-0.06750573,0.0023509131,0.027654735,0.037486933,0.0054362635,-0.007674348,-0.024504295,-0.03737529,0.07199294,0.015090398,0.019763047,0.11520456,0.07100169,-0.01950992,0.04976216,-0.0038962343,-0.042859294,-0.023739567,0.0055251163,-0.07130493,0.036612555,-0.0071071847,-0.034989625,0.08260794,0.017466998,0.030133566,-0.043287437,-0.0261286,0.045020524,-0.027185155,0.0039274143,-0.044215307,0.05556488,-0.06525038,-0.016554423,-0.025832316,0.055301208,-0.012784713,0.027806945,-0.10382802,0.032488775,0.0010398073,-0.013377499,-0.00018229126,0.025519015,-0.051092822,-0.02712102,0.047562137,-0.06754188,0.033189535,-0.03108642,-0.061758954,-0.06813619,-0.069890365,-0.057295293,-0.0032071352,0.026405174,0.021436712,0.026496064,0.14817566,-0.019618787 +2.7.8.30,The enzyme shows no activity with UDP-4-amino-4-deoxy-beta-L-arabinose.,384,1.0,-0.0025172587,-0.06027553,-0.037952464,-0.041016556,0.022313248,0.028418578,-0.07686257,-0.012067218,0.008191889,0.0046456023,0.07685267,-0.036792822,-0.02868575,0.049185313,-0.054032058,0.06568835,0.018813083,-0.062484343,0.013230796,-0.051949363,0.00041062234,-0.0030937763,-0.0033817645,-0.014782505,0.10419239,0.016826628,0.06896883,-0.056475908,-0.048195787,-0.06619291,-0.0051576025,-0.042628225,0.015595642,-0.030962743,0.09414477,0.11266897,0.0025782147,-0.0522146,0.05087876,0.00089364755,0.09867356,-0.009568298,-0.01859422,0.0061628297,-0.011496128,-0.018921876,0.008219306,-0.03250562,0.07330337,0.015347172,-0.026972622,-0.07235905,0.00856624,-0.010588573,-0.05410404,-0.049565993,-0.056190867,0.040917598,-0.061599284,0.04327925,0.012305152,0.01752605,0.027363552,0.006579352,0.014671839,0.051955204,0.054237846,-0.062373064,-0.0256754,0.004327417,0.002596786,-0.039982814,-0.056677885,0.05118234,-0.047459297,-0.029911876,-0.028357806,-0.08082367,0.025704794,-0.0048481943,-0.016631149,-0.037621584,0.022346478,0.039436277,0.019023543,0.021235395,0.009507051,-0.009129312,-0.011478202,0.0261838,0.0009630833,0.052653726,-0.08745643,-0.021231368,-0.0005501771,-0.009718442,-0.035575375,0.042856194,-0.08294796,-0.008129978,-0.03975982,0.05941359,-0.05855055,-0.07793126,-0.03417766,0.05012963,0.010439631,-0.018364774,-0.051363043,-0.03210677,-0.005239843,0.0054586264,0.10233255,0.05302678,-0.052956518,0.039525114,0.0060936026,-0.1087405,-0.08784027,0.03162058,0.031174105,-0.03490703,0.13866182,0.041669477,-0.07998878,0.087766126,-0.07280249,-2.6626214e-33,0.047368243,-0.029496973,0.058417875,-0.009656154,0.028533584,0.0271888,-0.023323359,0.05435645,-0.019955572,-0.009362252,-0.061194886,-0.04917151,0.08387558,0.025222108,0.018281257,0.04251043,0.10837707,-0.052158117,0.0544745,0.01869582,0.013432009,0.0064528543,-0.038987298,0.019247934,0.009668801,0.05130517,0.012014481,0.010519607,0.063040294,0.012290913,-0.114407316,-0.043701835,-0.09802037,-0.03123183,0.0058106007,-0.01375103,-0.06233523,-0.028030919,-0.036826458,0.0041565644,-0.02094524,-0.03636457,0.0082709985,-0.07872513,0.06389076,0.011606997,-0.015582839,0.027536618,-0.009836163,0.06893915,0.064431235,0.0056586466,0.05067736,-0.06031432,-0.007065754,0.027676517,-0.044534408,0.009028796,-0.057864565,0.04177834,0.034911882,0.06704203,-0.060205594,-0.023682527,-0.012597792,0.053981066,-0.06863477,-0.078009084,-0.02205466,0.018243369,0.030650688,-0.012383024,0.083948776,0.061986376,0.03903844,-0.05360505,-0.036985558,0.009278986,0.05535371,0.011482312,0.03190137,-0.036826517,0.055622175,-0.005360443,-0.03743855,0.009207026,0.051830087,0.069087856,-0.00557386,0.00992603,0.076753646,-0.015033576,-0.10032705,0.02197025,0.024171535,2.8692688e-34,0.059716042,-0.032939784,-0.031087566,-0.07681085,-0.05516665,0.06527808,0.1040151,0.040564444,0.13121966,-0.010134653,0.1777777,-0.062644064,-0.043960627,-0.09027758,0.073746495,0.054060303,-0.102025904,0.011411204,-0.061796736,0.0148588335,-0.022523936,0.13158531,0.0076483204,0.055266697,0.050526496,-0.021449996,0.036444426,0.13541803,0.021565726,0.040985633,0.040782377,0.05750708,-0.07283224,-0.05539198,-0.048340004,0.069883004,-0.032843646,-0.012908296,0.007414521,-0.031131107,0.009322132,0.088931195,-0.035642788,0.07439447,0.011065098,0.086192995,-0.05936214,-0.008088831,-0.016894681,-0.083619304,0.042424187,-0.004615853,0.0030343528,-0.008397907,0.045957852,0.06920074,0.018523442,0.0066096247,-0.027869359,-0.021450339,-0.018731149,-0.06629661,0.035581484,-0.009572014,0.009525289,0.04581955,-0.0033114988,0.023441738,0.064228825,-0.021366945,0.07071608,0.0028000146,-0.030073976,0.028291184,0.011812408,0.11275197,-0.14285387,-0.0427261,-0.0032076929,-0.09286645,-0.04483538,0.018679725,-0.07788,-0.062670015,0.0737042,-0.058811665,-0.006379144,0.06918196,0.016579036,0.0573772,-0.010038071,-0.04233703,-0.06953237,0.08660105,0.049346726,-2.4607413e-08,0.0756782,0.0076059783,0.07896194,-0.08695046,-0.031683657,0.044351522,0.054154888,-0.0038990278,0.016852176,-0.019355038,-0.047771268,0.04328237,-0.113278836,0.051400173,0.00067198253,0.0046743588,-0.028855842,0.025796326,-0.016865855,-0.04440734,-0.0724064,0.02133962,-0.14574689,0.03705984,-0.021429028,-0.06446762,0.06200422,0.0098099625,0.031493824,-0.05123293,0.008345927,0.007769207,0.013903124,-0.07170638,-0.10830501,0.018237656,-0.02249366,0.032524846,-0.03676989,0.07469431,-0.025413493,-0.07135193,-0.056038238,-0.03626359,-0.015589341,0.0069877338,0.036381755,-0.034482986,-0.016878793,0.02384291,0.094399884,0.013881189,-0.07426118,-0.0028749502,-0.023834273,0.0055903047,-0.011616577,-0.06208019,-0.017936647,-0.04246747,-0.007337715,-0.07095476,0.08901327,-0.026087455 +6.3.2.35,"The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.",384,1.0,-0.011367648,-0.037178356,-0.10275117,-0.04986544,0.026480408,0.011271797,-0.040535834,0.06605155,0.06522976,0.005722214,0.016085366,0.05264084,0.022154232,0.07725929,-0.033281483,-0.037510477,-0.056014232,0.019260397,-0.0127766635,-0.006258303,0.019451324,0.034824014,0.019561332,0.0007867289,0.004526201,0.021982986,0.033368252,0.035390176,0.018626643,-0.06822704,0.0160996,-0.08161594,-0.024793603,-0.034283068,0.072365336,-0.0015904264,-0.022295183,0.036430478,0.0402838,0.039325885,0.03726439,0.016196907,-0.011932165,-0.038668513,0.004749132,-0.031066304,-0.053890716,0.045835607,0.060359817,0.033928256,-0.028611928,-0.08954777,0.00466617,0.0048114685,0.055729162,0.04080705,-0.10381232,-0.024734959,0.024426278,-0.019218488,0.056012128,0.062430926,0.06974464,0.0013156253,-0.06138718,-0.089205734,-0.0051254723,-0.06341554,0.0673057,0.035033606,-0.075075425,-0.059232626,-0.013122779,0.027646232,0.07023243,0.0092652,-0.015689436,-0.05246904,0.03738728,-0.068849824,0.048797667,0.014622764,0.005921466,0.10576154,0.001897624,-0.022034932,0.061132256,-0.023106052,0.07023402,-0.0031399454,0.08043906,-0.082194634,0.011752136,-0.06975543,-0.0740666,-0.06877112,-0.0153365,-0.023880273,-0.060618494,-0.01823859,-0.03021328,0.018146541,-0.098126285,-0.06274093,-0.04737622,0.0017741383,-0.01643499,0.042442005,0.039678052,-0.031757977,0.01781107,0.027215647,0.031899896,0.006202233,-0.062024377,0.08604892,0.009271622,-0.06337578,0.029473195,-0.029658167,0.04944393,0.0430339,0.049824785,0.095214956,0.04848028,0.091192,-0.054365844,1.7058493e-33,0.0617633,0.027871968,0.028505156,-0.015941167,-0.020139469,-0.02998789,-0.079023056,0.025375035,-0.025077567,-0.064708374,-0.099382155,-0.05300465,0.01764458,0.08573997,-0.014685129,0.049035516,0.012475187,0.033440437,0.0237201,0.038403783,0.023449033,0.052975994,-0.0018469158,0.008509739,0.084047474,0.043159615,0.008214171,0.050733604,0.13796741,0.00096680835,-0.06609292,-0.062132042,-0.03389458,0.0068286066,0.026596127,0.014979405,-0.048664737,-0.034476064,0.061302014,0.08300594,0.028402627,0.0014194933,-0.0061173323,-0.05346007,0.028071702,0.0003759061,-0.016400563,0.10585157,0.026750717,0.039905794,0.084650144,-0.04439741,0.043176156,-0.007914225,-0.084932126,0.029818548,-0.041484717,-0.018336443,0.060019888,0.05916226,0.023538677,0.027508592,0.011739382,-0.005115151,0.033175264,0.0344019,0.008533513,-0.029876126,-0.03182724,0.00534444,-0.11077534,-0.0011588093,0.09261652,0.043161876,0.014759287,-0.061851054,-0.04395314,0.030581104,0.06744978,-0.035479568,-0.060221534,0.027966863,-0.020075927,-0.037647944,-0.024286522,-0.032189284,-0.023948317,-0.074094065,-0.030746348,0.053410944,-0.048972283,-0.048039258,-0.074778214,0.06284986,0.006110011,-3.2443133e-33,0.026572207,-0.12428718,0.06778133,-0.0003904385,-0.09518708,0.087660305,-0.03384879,-0.013473692,0.06542287,-0.03953176,0.07689719,-0.045176625,0.02448932,-0.06442691,-0.020561798,-0.029476836,-0.078524746,0.071644455,-0.03792314,-0.018393246,-0.042170778,-0.02770056,0.018144619,-0.0034146423,0.035750207,0.020931209,0.008677288,0.039565846,0.04008731,0.00028369203,0.002710944,0.026618185,-0.08471164,-0.03426539,-0.11907111,0.1421554,-0.04255675,-0.0468294,-0.008813142,0.005311946,-0.0021537442,0.012386401,-0.013355501,0.05511613,0.015384499,0.059760265,0.0015950922,-0.02375276,0.05407372,-0.030768566,0.031104747,-0.04674681,0.042694222,0.05656607,0.010550378,0.07675398,0.066096045,0.030734556,-0.007741557,0.021385435,-0.023163456,-0.065719955,-0.012392121,-0.015124484,0.050967544,0.019647833,-0.011590646,0.098602206,0.12508655,-0.048446048,0.08406752,0.020397717,0.0577796,0.019211082,0.007463323,0.041724056,-0.040911756,-0.07483673,0.032617323,-0.061987296,-0.03778206,-0.012928444,-0.039122798,-0.019933002,-0.033064906,-0.0230365,0.039348323,0.12196765,-0.015961815,0.08178969,-0.032023605,-0.008147456,-0.007617517,0.055313546,0.0850734,-4.351199e-08,0.09841418,-0.07327458,-0.020315653,-0.028150728,-0.0031323333,0.010736877,-0.049531773,-0.011694238,-0.05920773,-0.03146391,-0.008218135,0.008584683,-0.045476034,-0.04085497,-0.037394714,0.10473669,-0.08674586,0.027072113,-0.025428472,0.03798412,-0.12570846,0.010048064,-0.113683045,-0.0023347754,-0.0020041398,-0.05590688,0.049037132,0.04460384,-0.07811713,-0.010247219,-0.0028090926,6.5346256e-05,-0.11340571,-0.039623756,-0.08159513,-0.03148021,-0.08132617,-0.0076194424,0.028327804,-0.00068972824,0.02550292,-0.022490542,-0.11171657,-0.014181368,-0.012249909,0.026279561,-0.030595273,-0.019466545,-0.100760184,0.005942804,0.0033730736,0.0342923,0.05404113,-0.05684601,-0.11588773,0.042930927,-0.033726104,-0.09320625,-0.00517984,-0.041314915,-0.05672259,-0.012013397,0.1834012,0.045075778 +1.2.1.79,"This enzyme participates in the degradation of glutamate and 4-aminobutyrate. +It is similar to EC 1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. The enzyme from Escherichia coli is 20-fold more active with NADP+ than NAD+ [2].",384,0.99999994,-0.025598437,0.006938686,-0.029008549,-0.032801386,0.06610487,0.06839601,-0.07495482,0.052607745,0.021239659,-0.006249417,0.0016510121,0.009178313,-0.05014946,0.032073777,-0.0240949,-0.004387167,-0.011955093,-0.031446837,0.00349044,-0.07077099,0.03940911,0.019349134,-0.025599757,-0.032015745,0.09311688,0.07147642,0.033849817,0.004797648,-0.035618994,-0.05524434,0.00463622,-0.046805646,0.018892463,-0.047307495,0.007499088,0.07155708,-0.09569039,-0.04682613,0.051402193,-0.014859235,0.0057516843,0.048372515,-0.08013077,-0.04616201,-0.026609734,-0.06523406,-0.0037770083,0.04349718,0.015673012,-0.036296114,0.010640435,0.00084965775,0.037624557,-0.0018152725,0.059600048,-0.017843395,-0.027745185,-0.049192045,-0.049153466,-0.04296202,-0.0033797733,-0.049381293,0.0080148615,0.004169844,0.06957108,-0.046587795,0.12065686,-0.06860835,-0.000764178,-0.031819317,-0.17003857,-0.023950476,0.030612595,0.06996336,0.013541959,-0.008610269,-0.047279015,-0.0595597,0.083592236,-0.031558786,0.0851599,-0.0008211195,-0.034056496,0.027572352,0.06418399,-0.0006982936,0.079300694,-0.008824505,0.0019088805,0.03208859,0.0077200616,-0.019827561,-0.013640152,0.026581168,-0.12872095,0.031606853,-0.027737431,0.050148826,-0.02733705,-0.06258691,0.01281064,0.13850145,-0.013161432,-0.049435664,-0.0053063785,0.019223403,0.010259975,0.124098726,-0.039068002,0.008026849,0.02260383,-0.048587613,0.004048665,-0.03117187,-0.018381657,0.1233541,0.034763366,-0.010783372,-0.07705946,-0.033584688,0.04577556,-0.039486233,0.05484355,0.021730203,-0.042813912,0.054110784,-0.12407287,2.2578131e-33,0.045281574,-0.033538535,-0.041024882,-0.031347755,0.07653025,0.0074999826,-0.10515288,0.11022307,-0.037022542,-0.045177907,-0.035247196,-0.07170974,0.06171601,-0.018015273,0.0019886922,0.006265737,-0.05248831,-0.04917564,0.010416794,0.011724539,0.0007304148,0.058102623,0.0075718085,0.034202214,0.040738977,0.016815571,-0.04215308,0.08943441,-0.030183734,-0.001608226,0.041655783,-0.08013751,-0.18845685,-0.013985381,0.06606836,-0.04451539,-0.015188911,-0.045573395,0.015930463,0.05036919,-0.07682381,0.07444242,0.017051663,-0.027722767,0.04062897,-0.08872153,0.013119704,0.092770696,0.048098247,0.06595866,0.056045912,-0.06880867,0.10206341,-0.094243385,-0.028814381,0.06599708,0.0054608723,-0.0066088336,0.011117103,0.089880675,0.034420762,0.048789207,-0.06045588,0.0121559845,-0.0070390394,0.027734468,-0.064320534,-0.0851744,0.057866037,0.042770084,-0.040185995,0.030015789,0.076651394,0.024069095,0.0022855198,-0.05204565,-0.015820771,0.03266593,0.025330907,0.041656774,-0.04332462,-0.022598425,0.003343043,-0.036496915,-0.004622542,0.021533985,-0.0027269686,-0.051209144,0.028869385,0.067719184,0.04021333,-0.04442174,-0.033050824,-0.025388408,0.052544363,-3.5181462e-33,0.07565049,-0.036272816,-0.0035353221,-0.05043849,-0.068323225,0.0859393,0.023195997,-0.010172012,-0.04033966,-0.05203483,0.084340334,0.054846678,0.061491974,-0.021002347,0.08595461,-0.03226848,-0.07887812,0.038124282,-0.048515204,-0.0076256115,0.032447293,0.11486849,0.045826968,-0.026186414,0.06629331,-0.037556343,-0.009049378,0.06273924,0.03691185,-0.010069849,-0.012311864,0.022110352,-0.06873003,-0.00074410805,-0.040247116,0.013649429,-0.024653045,-0.010429563,0.00058331504,0.027531078,0.0052466746,0.07911258,-0.019516664,0.042533092,0.049772188,0.056766707,-0.07676207,0.011583824,0.018131755,-0.07861625,0.035552338,0.028535761,-0.06488159,0.026376797,0.03878838,-0.010546875,-0.008868223,0.018155094,0.027132913,0.021137858,-0.030088102,-0.06029345,0.06314104,0.036211014,0.062074125,-0.014578579,-0.023160474,0.010916697,0.028904788,-0.0017929515,0.06625688,-0.03269893,-0.025599351,0.014132493,-0.03100768,-0.024728002,-0.1006042,0.05086294,-0.009564826,-0.0100703705,0.025186887,-0.0104927635,-0.05747424,-0.073346145,-0.031012578,-0.07727943,-0.005041305,0.107138775,-0.0202656,0.05878032,-0.02638725,0.026367491,-0.07258834,0.036688652,-0.008876155,-3.7674514e-08,0.026718559,-0.029910091,0.025203584,-0.052447576,0.068797484,0.026530432,-0.01817424,-0.033950742,0.057430785,-0.0011354132,-0.00093884143,0.1365492,-0.015003544,0.032500852,0.0026518195,-0.006256425,-0.031695154,0.035361495,-0.0098428605,0.010178582,-0.0684851,-0.01099003,-0.13146774,0.041703578,0.046249326,-0.040044658,0.031718124,-0.0011556994,0.030142931,-0.10819303,-0.01708508,0.030539412,0.10542522,-0.03985932,-0.053119645,0.01893926,-0.060326893,0.0094602695,-0.058594503,0.106185906,0.017421002,-0.085934944,-0.057802435,0.00029142122,0.003429968,0.056130104,0.06972987,-0.023183668,-0.117077425,-0.037329745,0.04781407,-0.06900752,0.040926255,-0.033568546,-0.08578128,0.02742242,-0.04497938,-0.08875564,0.026788317,-0.022053381,0.0327264,0.0011389134,0.11982488,0.009425615 +1.14.99.41,Contains an Fe2+-4His arrangement. The enzyme is involved in retinal biosynthesis in bacteria [2]. ,384,1.0,0.0066203806,-0.041227482,-0.08048565,0.070896834,0.0887019,0.01109682,0.008125253,0.027969724,0.0013191041,-0.02379934,0.020459281,-0.078302346,-0.047273215,0.0553138,-0.06315184,-0.018135192,-0.09445528,-0.03296609,0.011603942,-0.02516492,0.11369933,-0.009796489,0.013804733,-0.06702524,-0.05356499,0.081460945,0.10145052,-0.05130654,0.014888735,-0.113605276,-0.032028057,-0.02523465,0.059986934,-0.076681495,0.02875442,0.06765006,-0.0016498428,-0.06898989,0.061943132,0.01685539,-0.0062826676,-0.0060461923,-0.007858213,0.009563371,0.03826037,-5.9221475e-05,0.09100758,-0.0071792323,0.026060974,-0.015211062,-0.119721435,-0.019783942,-0.0805815,0.05420947,0.08086389,0.04542524,-0.0618979,-0.025671229,0.0030113563,0.023054833,0.09892743,-0.062660545,0.020555234,0.00014951883,-0.021192234,-0.008039543,0.02648052,-0.07793642,0.03127344,-0.07676317,-0.020432942,0.0029073055,0.029803392,-0.017784389,-0.07154677,0.033509392,0.08309796,-0.05543026,0.09745708,-0.012177236,0.030309238,-0.003134075,0.023110718,0.09217186,0.060043238,0.0409249,-0.0053351084,-0.038609575,-0.027973289,0.052797545,-0.014762479,-0.034458652,-0.0591423,-0.05860001,-0.051231313,0.041823566,0.026030095,0.022689981,0.016295934,-0.02520644,-0.030661786,0.037945557,0.018541671,-0.064508736,-0.03686443,-0.039881732,0.00905187,0.13563564,0.0010345788,0.03253699,0.03794886,0.06457938,-0.0011082643,0.02423971,-0.007951027,0.044694256,0.027280029,-0.057113547,0.013737741,0.02113207,0.057933196,0.028946528,0.06127944,0.043884926,-0.029997721,-0.0053163557,-0.12775633,4.771968e-34,0.03292942,0.052957486,0.0040431893,-0.04313015,0.038082216,-0.026191723,-0.06379496,-0.0011465894,-0.07805177,0.0026626054,-0.092550285,-0.11716423,0.02508066,0.056005042,0.020606255,-0.06504374,-0.035321873,-0.009910085,0.030917645,-0.050910518,-0.05395709,0.123792656,-0.022778373,-0.03398468,0.021789452,0.046416618,-0.024574619,-0.02153925,0.041297782,0.0056333323,0.0730569,-0.013476665,-0.10017367,-0.0043882616,0.11805991,-0.013783295,-0.002411199,-0.049960867,-0.025903238,0.0039162035,0.011898781,0.083622456,0.013020664,-0.050867002,0.061907638,-0.055288818,-0.07063025,0.13250975,0.04880508,0.07478974,0.010483481,0.0030548112,0.07899405,-0.067827895,-0.076647066,0.015846096,-0.030717295,0.070521854,0.04170872,0.04055207,0.031688496,0.04708309,-0.00337424,0.08341961,0.04696093,-0.0062797354,-0.034089558,-0.0056308596,-0.014760012,0.06010082,-0.03501721,0.039893482,0.043528803,-0.0573525,0.012592837,-0.046406,-0.07401609,0.0032137665,0.040093865,0.026340613,-0.042490277,-0.0244876,0.09079186,-0.031076021,-0.05192431,0.042511173,0.006712745,-0.016893495,-0.0072641573,0.004587637,0.06698147,-0.032078873,-0.083316915,-0.0274613,-0.0066728387,-1.8432178e-33,0.018354598,-0.08856173,0.07391667,-0.07026994,-0.11749377,0.03189116,-0.0026452623,-0.019552555,0.017038103,0.00045614183,0.08134597,0.017741272,-0.014676557,-0.08671099,-0.008166032,0.0002015002,-0.0391648,0.06495315,0.035640527,-0.027035238,-0.029844327,0.059210338,0.013732128,-0.03959026,0.07271079,0.057566386,0.0105404565,0.047770917,-0.019914156,0.024746027,0.018610192,-0.020854974,-0.057766147,-0.06773765,-0.05079339,-0.018040452,-0.025836086,-0.036860984,0.033911977,0.02826555,0.027929435,0.0104850335,0.058441024,0.11529022,0.042477068,0.018774388,-0.023393579,0.08331361,0.00710572,-0.016987676,-0.04743714,-0.06461082,-0.097733445,-0.017471004,-0.020198075,-0.0048088185,0.032368757,0.041709,0.0065745604,-0.0057441085,-0.0036135695,-0.12710881,0.08064346,-0.02720802,0.090597466,0.05359054,-0.036021415,0.069089435,0.06923662,-0.04453903,0.15210117,0.0075702025,-0.041982513,0.028057238,-0.03401396,-0.026549635,-0.045222465,0.0010212103,-0.022560725,0.041660774,0.039346565,-0.0028578728,-0.045028303,0.012851084,-0.021989975,-0.074103706,0.06597102,0.09857158,-0.0033031066,-0.038875926,-0.06928887,-0.0012969516,-0.048778944,0.013930494,0.0046711834,-2.5603722e-08,0.027901744,-0.0775722,0.029309832,-0.08409036,0.01186945,0.025704306,-0.016215054,0.028399851,-0.004522432,-0.012777198,-0.03251183,0.089841984,-0.012102066,-0.018265981,0.0662289,0.025407314,-0.021949772,0.027744474,-0.03165628,-0.025301771,-0.0770488,-0.04509736,-0.10486341,0.05090891,-0.017290106,-0.03856304,-0.009671833,-0.012864837,0.01668656,-0.040754907,0.03918032,0.038101792,0.036186628,-0.040973075,-0.1267303,-0.03263416,-0.062223047,-0.0344392,-0.040718336,0.017329631,-0.004947929,-0.031722993,0.0054789926,0.022523727,-0.04627665,0.00018730629,0.019916033,0.005665154,-0.04715485,-0.007986246,-0.014716309,-0.010958481,0.011174141,-0.041712794,-0.16657318,-0.011723435,0.03495566,-0.046881434,0.043559514,-0.0507775,0.036700614,0.050956897,0.15465645,-0.007522013 +2.1.1.187,The enzyme specifically methylates guanine745 at N1 in 23S rRNA.,384,0.99999994,-0.05567326,-0.07467982,-0.09685498,-0.013850709,0.025413444,0.024340663,-0.035732888,0.0049531367,-0.06074702,-0.046369135,0.034332562,-0.04259906,-0.058253326,0.045173205,-0.058960736,0.013333987,-0.079515584,-0.042170316,0.055889077,-0.031200403,0.03019599,0.07729359,-0.0152057,-0.014570523,0.011428157,0.020973118,0.024887355,-0.027469473,0.019273415,-0.07279189,0.005552465,0.006819745,0.011733658,0.07033134,0.0032460366,0.069940306,-0.08728376,-0.003356857,-0.00658502,0.02942025,0.07466185,0.05269161,0.02534717,-0.015768772,-0.006583181,-0.004864996,0.03284107,-0.022598553,-0.012757383,0.017419338,-0.037306033,-0.10052525,0.0072583994,0.023926094,0.096684076,-0.019225242,-0.05489467,-0.06224127,-0.064276375,0.012401339,0.089070946,-0.052488733,-0.000434581,-0.112192854,0.01830765,0.004589407,0.05995332,-0.043549318,0.004068648,-0.044975407,-0.014139214,-0.012975916,-0.055916272,0.030871166,-0.1015439,0.07723473,0.052593224,-0.061848067,0.021812646,-0.010977623,-0.018061249,0.040792923,0.029478641,-0.009665032,0.10579686,0.033074602,0.030992746,0.102041416,0.05410191,0.011937579,0.05937524,0.05531859,-0.010880659,-0.00416675,-0.08373968,0.0028671143,0.0042915773,-0.006449455,-0.008850562,-0.0106775295,0.019990787,0.09079535,-0.03590668,0.008449334,-0.08079944,0.03494503,0.0420485,0.03391084,-0.053004872,-0.0070491745,-0.009191233,0.0991925,0.016261932,0.020804398,-0.003196155,0.050864644,0.01753962,0.014225731,-0.011379108,0.030520517,-0.06304031,0.02946695,0.019003537,-0.010568534,-0.08984644,0.012279561,-0.112238504,2.3169747e-33,0.015139201,-0.016279254,-0.029674541,0.0049390066,0.06444718,0.070329525,-0.08310739,0.035934415,0.025230357,-0.058333486,-0.078411244,-0.10184581,0.04023113,-0.030301511,-0.09265936,0.06560688,-0.019567337,-0.021296397,-0.0033671025,-0.11883264,-0.009907804,0.008823177,-0.07891188,-0.033752818,-0.023279378,-0.002151329,0.026095787,-0.011745067,0.11471389,-0.047438808,-0.083839476,-0.11639406,-0.050010294,0.046140853,0.07948074,0.05705931,0.010838564,0.029091053,0.022903016,0.094560795,0.041113697,0.028912302,0.009575746,-0.0042870482,-0.010415539,-0.012822219,-0.04749239,0.08161571,0.024913695,0.032816548,0.028125968,-0.012115757,-0.005819142,-3.352296e-05,-0.06797711,-0.014820874,-0.022265919,-0.028680243,-0.024012502,-0.0068056295,0.03331275,-0.06964534,0.04187457,-0.0024110065,0.005542715,0.03718762,-0.11241812,-0.0825279,0.050827175,0.066319235,-0.01249058,-0.057827365,0.16018036,-0.042574294,0.04223584,-0.027233867,-0.07136662,-0.026690923,0.058905642,0.07726914,-0.0643891,0.03457558,-0.00851129,-0.006698501,-0.08875676,-0.010739184,0.03594685,-0.06627335,0.046323065,0.039397717,0.06002154,-0.032329265,-0.017239928,-0.04370855,0.0004819269,-1.5422818e-33,0.052189864,-0.06270193,0.07473714,-0.038630076,-0.025586408,0.004712505,0.014139826,-0.03631273,-0.07473162,-0.08820036,0.14819686,-0.0010711811,0.06334363,0.005708977,0.057089485,0.021139672,0.0071618566,0.08996924,0.0048356866,-0.0061029796,-0.019165948,0.010784128,-0.044896625,0.05676517,0.042092055,0.062291007,0.04147727,0.0049157976,0.091389015,0.009404468,-0.08652908,0.015371025,-0.055298924,-0.014443807,0.017877031,0.06573379,0.02468544,-0.012915016,-0.04682606,-0.007694351,-0.038595792,0.032599617,-0.008409881,0.14072193,-0.022397352,0.058579464,0.0108523145,-0.03745645,-0.029407345,-0.049661465,0.02898392,0.0012416687,-0.022475982,0.025978118,0.044547036,0.0095428005,-0.024628395,0.0032493053,0.0037397735,-0.00047410108,0.014031051,-0.056874085,-0.07273118,-0.019468395,0.0012151798,0.040081713,0.0018942842,0.0518968,0.07099153,-0.036559388,-0.011376139,0.019269863,0.052546583,0.0101244785,-0.055210996,-0.108159624,-0.012154043,0.0027083843,0.015698321,-0.13447851,0.034298785,0.007845793,-0.07055531,-0.044673666,-0.005745333,-0.046195995,0.09640001,0.114899725,0.031051243,0.03207924,-0.058192924,-0.008753717,-0.10359912,0.077319324,0.05790377,-2.2247418e-08,0.027734382,-0.10488413,-0.0034674443,-0.028751764,0.008396052,0.10770504,-0.05118519,0.046600495,0.047889825,0.018854018,0.00921066,0.032141976,-0.008890307,0.07240065,0.004045887,0.038614165,-0.03790817,0.020018838,0.025784915,-0.008552017,-0.07936332,0.06160967,-0.076947816,-0.0038234752,-0.037942186,0.006960197,-0.017437883,0.14779161,0.015515179,-0.08031946,0.04650531,0.0030060902,0.10828279,-0.025350776,-0.009261176,0.051257245,0.08035129,0.00068248116,0.013084364,-0.02142958,0.0046392395,-0.0037287958,-0.059359357,0.02193602,-0.0683742,-0.060827617,-0.045124967,0.053349033,0.017425613,0.046109,0.07156463,0.025740588,0.05414919,-0.00365755,-0.046788238,-0.02318996,-0.013082132,-0.051901065,-0.074926116,0.03235874,0.016053585,-0.06931149,0.09427492,-0.061385844 +2.1.1.188,The enzyme specifically methylates guanine748 at N1 in 23S rRNA. The methyltransferase RlmAII confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae [1]. ,384,0.99999994,-0.0092124,-0.019082172,-0.15949985,-0.016173502,-0.011154838,0.042940706,-0.07546817,0.06607106,0.016977794,-0.037972454,0.0018732294,-0.043465775,-0.0065440955,0.081391536,-0.087082446,-0.039693933,-0.10808948,-0.03963025,0.052448723,-0.03638673,0.041425947,0.077447996,0.014988173,0.04027098,0.011349665,-0.006627207,-0.03600276,-0.033044443,-0.001034411,-0.072106,-0.0052766697,-0.0008208593,0.03808421,0.012415212,0.06385976,0.078171656,0.0009475048,0.011553881,0.068381935,0.015545438,-0.019563787,0.015894799,0.04717214,0.03909406,-0.03778307,-0.0015362978,0.045877583,0.0034552738,0.049204573,-0.009189425,-0.06640047,-0.08443066,-0.0008164575,0.06948716,0.12541991,0.008982418,-0.039324723,-0.04702178,-0.010528889,-0.0034401377,0.08878682,-0.056399036,0.033934064,-0.077525355,-0.07705939,-0.015260818,0.055509165,-0.050041422,0.029924612,-0.022723686,-0.056520082,-0.022970902,-0.043790627,0.046328098,-0.062149953,0.05293118,0.026992705,-0.04028649,-0.020416468,-0.036534224,0.03183603,-0.0031998167,0.012587454,0.022984587,0.055932324,-0.044487394,0.014847379,0.073345795,0.10741875,0.055464778,0.08335489,0.039545495,0.015811214,-0.06507157,-0.059838388,-0.0015583694,-0.06978055,-0.0006540944,0.029837115,-0.0054935035,0.0016834765,0.07296135,-0.012670578,0.0336297,-0.032453995,0.024313174,0.0106756,0.03257447,-0.0038185026,-0.043806817,0.034200296,0.076189585,0.054142285,0.016071562,-0.033684295,-0.013211279,0.09075763,-0.013459579,-0.04981367,-0.006367501,-0.035464756,0.05195657,0.047924407,-0.007135484,0.0037305693,-0.015655374,-0.10901018,6.467417e-33,0.03806558,0.012649869,-0.03442184,-0.013517193,0.05024632,0.004873212,-0.05596617,0.012255822,0.018460628,-0.06093897,-0.12540504,-0.1452259,0.0030444895,0.018342568,-0.045218486,0.08242651,0.014872242,-0.025596544,-0.05225212,-0.065369554,0.0029907268,0.0066359327,-0.08280193,-0.05250211,0.0033214705,0.07524016,0.010721973,0.014959354,0.114202455,-0.06933857,0.014385263,-0.09922393,-0.058964543,0.090816006,0.10665544,-0.009603942,-0.021492263,0.014653201,0.047159355,0.09559411,-0.008363245,0.061297256,0.011967879,-0.010721534,0.032373287,-0.015010722,-0.001828762,0.075302884,0.055681996,0.054197047,0.058862586,-0.040498808,-0.020469148,0.008420296,-0.04704766,-0.023365732,-0.0218003,0.033674795,0.0636461,0.032574054,0.006215559,-0.07433067,0.032254938,-0.009112074,0.0082089985,-0.009838782,-0.07768958,-0.047677167,0.017203238,0.058537763,-0.0172776,-0.0601641,0.060578953,-0.003445587,0.043486163,-0.009004376,-0.06862819,-0.051849,0.0859913,0.04363567,-0.10236008,0.0145666655,-0.013217847,-0.033800334,-0.09359216,0.046636403,0.029703163,-0.11185483,0.05964922,0.034022465,-0.023673382,-0.080524795,-0.06692021,-0.018998485,0.04163485,-5.1712568e-33,0.09627356,-0.046842586,0.055752344,-0.076510906,-0.09213073,0.027208528,-0.06242743,-0.012346337,-0.054219052,-0.10324523,0.14064223,-0.0033772301,0.013305412,0.0171441,0.016877398,-0.022566881,0.05763205,0.072449654,-0.014683088,-0.0144164795,-0.04808071,0.02231292,-0.046663247,0.038124442,0.06698977,0.032687858,0.029446818,0.034420565,0.08067201,0.027404899,-0.06820379,-0.029071651,-0.044137385,-0.037399925,-0.015791038,0.09858117,-0.028786847,0.0027081096,0.0070583257,0.008631201,0.05367438,0.041165363,-0.015982348,0.08676646,-0.031858385,0.069037914,-0.06751103,-0.008648527,0.032966524,-0.05532243,0.030253604,0.027779633,0.039985023,-0.0024743306,0.029165901,-0.027395463,0.0004324227,-0.0002100144,0.0033304282,-0.027962333,0.007487964,-0.06797514,-0.031663507,-0.016019851,0.043548748,0.07854026,-0.034260035,0.10179177,0.083673134,-0.039455414,0.021342242,0.002263712,0.045184642,0.024071794,-0.046912134,-0.0991933,-0.06982288,-0.026863419,0.019188715,-0.06709112,0.050687738,0.010718631,-0.02996631,-0.06427563,-0.014662627,-0.030305775,0.07228289,0.05166129,-0.008534349,0.027412118,-0.01621631,0.008613622,-0.053654533,0.07214473,0.047522005,-3.5125872e-08,0.050620295,-0.05946437,0.0025807938,-0.04128034,0.016896324,0.05829331,-0.078915805,0.0002848594,-0.018242124,0.038547743,-0.022864198,0.011575832,-0.0011875526,0.03804581,-0.020925948,0.056490082,-0.06713502,-0.006814219,0.0005198551,-0.012194654,-0.07200631,0.046441887,-0.08045746,0.025727501,-0.005964684,-0.001703841,0.02197495,0.09512221,0.005712042,-0.05464195,0.079900436,0.021787116,0.03713281,0.0037752932,-0.043780394,0.029650126,0.0010021419,-0.016616074,0.036520988,-0.01883238,-0.00083174405,0.011260379,-0.049749285,0.021132588,-0.094604105,-0.04096222,-0.054941524,0.030859858,-0.029638363,0.012913975,0.15432885,0.030687064,0.06662242,0.029642683,-0.07018816,-0.020250367,-0.008685332,-0.004414916,-0.072603606,0.0132803535,0.0258949,-0.13048671,0.14982024,-0.08022127 +2.1.1.189,The enzyme specifically methylates uracil747 at C5 in 23S rRNA.,384,1.0,-0.029198553,-0.010899716,-0.08304443,-0.00685106,-0.018334312,0.02829221,-0.10270917,0.0030298734,-0.0339904,0.017730897,-0.026331685,-0.051108632,-0.0548285,0.057246286,-0.054237086,0.014573176,-0.1243651,-0.014104603,0.011146731,-0.043408524,0.057252854,0.06391718,-0.039766226,-0.018184977,-0.00462936,0.016619235,0.05950923,-0.0013928466,-0.017419193,-0.06338563,-0.03440762,0.008377344,-0.0062921685,-0.044613335,0.026522428,0.07361977,-0.10973899,-0.044076838,0.043508396,-0.012370199,0.068343595,0.02774872,0.020551013,0.027501969,-0.046258945,-0.023470905,0.035487507,-0.022456722,0.015582484,0.008717047,-0.05434844,-0.07591725,-0.0095618935,0.02407172,0.06383451,-0.039636534,-0.065989695,-0.07134247,-0.0060014324,-0.072204694,0.036683947,-0.051767085,-0.0023054993,-0.08366874,-0.01200919,-0.002832862,0.022553505,-0.04494136,0.009920485,-0.085810125,-0.06955005,-0.045079004,-0.0012263841,0.09487133,-0.011143929,0.022348471,0.07403193,-0.10064062,0.03696567,-0.055554632,-0.0021169565,-0.004447168,0.0024233565,0.018123314,0.07627276,0.023714788,0.06454934,0.05357677,0.049464237,0.005829794,0.07145941,0.03881756,-0.03993627,-0.0587758,-0.06952246,-0.019616837,0.01167383,0.01001279,-0.022792436,-0.02167062,0.070224226,0.092049725,-0.07395607,-0.041220564,-0.046498828,0.021380404,-0.0023621377,0.11727174,-0.024701195,-0.029868456,0.017041693,0.086869195,0.013865234,0.0075002387,-0.023785617,0.04814341,0.00922521,-0.044270832,-0.039920177,-0.014216098,-0.06001155,0.003002722,0.058857862,-0.0021132997,-0.09161568,-0.030541992,-0.09788935,5.343486e-34,-0.01136061,-0.0029850763,-0.012221421,-0.0023177415,0.039382663,0.02948967,-0.018787682,0.005324708,0.028141214,-0.123210706,-0.08883168,-0.10048643,0.02825362,-0.063333526,-0.09242754,0.05269108,-0.014927267,0.014956492,-0.04652268,-0.08422425,0.0021849028,0.10680754,-0.034127057,-0.060032185,0.033594884,0.03137801,0.016071334,-0.006349501,0.08809747,-0.02529352,-0.02372307,-0.03436818,-0.06803494,0.046308435,0.13332331,0.08258602,0.009230498,0.012951684,0.008689261,0.087892205,0.039342247,0.023419918,0.024701213,0.0051955846,0.024702556,-0.04485701,-0.07239338,0.07184045,-0.03671989,0.0761653,0.0140209235,0.01749002,0.046203803,-0.030583005,-0.08219594,-0.031014632,-0.036637794,-0.038460333,0.0022587513,0.032882378,0.016163116,0.011029034,-0.0001686362,0.05521275,0.017904464,0.0038346231,-0.06497722,-0.07747021,0.032415155,0.08332519,0.010249355,-0.025096418,0.15300766,-0.06686572,0.030847888,-0.020027818,-0.08098001,-0.010128034,0.046240985,0.027227737,-0.014547577,-0.018262858,0.021584153,0.007059982,-0.052524984,0.006073924,0.030578624,-0.05941736,0.0040944507,0.045524847,0.098406866,-0.044358313,-0.04946831,-0.022089733,-0.014727521,-1.538476e-33,0.114724934,-0.099512,0.12256017,-0.018437285,-0.013327,0.0018247575,0.054950103,-0.03677372,-0.09621314,-0.07980981,0.17510714,0.025277888,0.04218927,-0.0020256161,0.03871015,0.03522737,0.051100224,0.05615171,-0.00022086583,0.026057463,-0.030023511,0.00805363,-0.06334848,0.11433101,0.03227103,0.03197478,0.049082473,-0.04396111,0.12709649,-0.037796084,-0.024274634,0.018702647,-0.034788974,-0.04894622,0.00079674926,0.10015197,0.0072436165,0.0035154133,-0.029024074,0.028371146,-0.018403502,0.0009269582,-0.05938348,0.08881203,-0.035728954,0.008165095,-0.034284625,0.0043763556,-0.018206853,-0.028209198,0.07426927,-0.037199773,0.021049503,0.008721028,0.043839023,-0.002207447,-0.008634498,0.05246137,-0.002256664,0.0066298875,-0.012153312,-0.022522962,-0.026119696,-0.0027479567,0.036006168,0.009851635,-0.053499922,-0.0073897536,0.033957385,-0.04915137,0.018028483,-0.010168581,0.037454095,-0.031564165,-0.029211424,-0.10999937,0.018730333,-0.026072035,0.025729362,-0.0691744,0.0120611945,0.0028694232,0.013245278,-0.008990554,-0.027658802,-0.049003463,0.071788184,0.08231404,0.00062785496,0.04521469,-0.038531996,0.010542282,-0.104333825,0.053554475,0.086047396,-2.2510525e-08,0.031852994,-0.0831827,-0.006793331,-0.038368482,-0.013878096,0.10863219,-0.04674874,0.032312762,0.06441393,0.07707441,0.031768266,0.013343386,0.024773285,0.033312984,-0.0124329645,0.02496571,-0.06609736,0.02707979,0.0441521,-0.00053472497,-0.115989074,0.034103278,-0.07182727,0.010096312,0.033132467,-0.037406698,-0.003255171,0.11218576,-0.03829496,-0.07526902,0.057079334,-0.028821694,0.07813521,-0.012669359,-0.0113547575,0.086006746,0.07287581,-0.005954249,-0.0040652463,0.021446949,0.013539711,-0.020392926,-0.06282327,0.03183623,-0.054464146,-0.07512495,-0.04877265,0.06341817,-0.000963317,0.0106628,0.065794945,0.03184574,0.03906321,-0.08476585,-0.005936198,0.010504718,-0.025252292,-0.05830764,-0.03213645,0.056903172,0.116765164,-0.024133729,0.084877566,-0.05241947 +2.1.1.190,The enzyme specifically methylates uracil1939 at C5 in 23S rRNA [1]. The enzyme contains an [4Fe-4S] cluster coordinated by four conserved cysteine residues [2]. ,384,1.0,0.016383942,0.0024434112,-0.084296614,-0.02003419,0.026318153,0.072410315,-0.11471112,-0.025245314,-0.007330194,-0.058840018,0.011746374,-0.060724664,0.01339776,0.05355827,-0.08141127,0.022054251,-0.14404398,0.00077373564,-0.0008074216,-0.038966265,0.018090293,0.039566893,0.0056676543,-0.029127235,-0.052589282,0.012425719,0.09331021,-0.04796844,-0.020666536,-0.05702879,-0.004670115,-0.025699008,-0.030639917,-0.020884823,0.02187109,0.08375431,-0.06695672,-0.02324057,0.043632373,-0.014794388,0.030908337,0.015619689,0.026588013,0.013153965,-0.03530685,-0.0031946301,0.039441478,-0.030080032,0.0032915743,0.01171936,-0.021780621,-0.047167834,0.043134037,0.046402298,0.039694797,-0.022358151,-0.031170629,-0.036796626,-0.006844072,-0.0061641308,0.10786927,-0.04088412,-0.04701341,-0.10349644,-0.02279719,0.04375877,0.021905515,-0.050129686,-0.0077127097,-0.10404835,-0.051244915,-0.028641604,-0.02729507,0.03668221,-0.046676245,0.06006689,0.07915171,-0.079181716,0.04762794,-0.053320587,0.020091016,-0.032597937,0.0421341,-0.011280312,0.07332749,0.009403393,0.038983304,0.00071949523,0.06080801,0.012746109,0.027966294,0.07339408,-0.049984887,-0.055288102,-0.05577878,-0.0016419529,0.008772127,0.052340515,0.03831227,-0.0026543485,0.08029872,0.10448783,-0.08064536,-0.039335385,-0.043930408,0.02784017,0.026809867,0.14041013,-0.029295906,-0.016649961,0.037088953,0.091767505,0.01706992,0.011750026,-0.039573647,0.04141939,0.013740259,-0.04775592,-0.06728376,-0.00785655,-0.04084749,0.020818189,0.048002448,0.016675334,-0.06951183,-0.030834185,-0.15044802,1.1303533e-33,0.017874306,0.04787464,-0.009969569,0.0023398888,0.059428915,0.016170492,-0.005117184,0.01988207,-0.031455576,-0.109487966,-0.072644554,-0.09031487,0.04724135,-0.084410824,-0.10574591,-0.027729701,-0.018289855,-0.0016817366,0.018506113,-0.09781267,0.0028306108,0.10840517,-0.029049259,-0.06048471,0.0062826034,0.008492849,0.023279527,-0.032436922,0.10342615,0.0014408894,-0.04911358,-0.022403175,-0.116324365,-0.030584276,0.14051881,0.030965062,0.02787312,-6.073196e-05,-0.0150305955,0.027203526,0.007912881,0.0050429055,0.0319626,-0.038207468,0.033135418,-0.07099722,-0.03448186,0.07650916,-0.045739755,0.08413571,-0.006253582,-0.015158914,0.054363195,0.0062595895,-0.08905048,-0.07797441,-0.0392961,-0.044510253,-0.00037408186,0.05669788,0.047121666,0.04500429,-0.027185416,0.04824893,0.061285056,-0.013182027,-0.0013996203,-0.04832101,0.03672625,0.12720367,0.01113367,-0.019604897,0.13379064,-0.06252287,-0.0016904359,-0.037190437,-0.076755315,-0.009564695,0.056726355,0.0180895,-0.041851167,-0.008533426,0.029203884,-0.032194808,-0.021365512,-0.015879257,0.032561563,-0.049108878,-0.028986866,0.03269362,0.08065708,-0.020437095,-0.03138161,0.020927072,-0.037388384,-2.0632683e-33,0.11548264,-0.05315315,0.10116273,-0.06761392,-0.038652744,-0.004507874,0.06503722,-0.025911437,-0.06376345,-0.058172435,0.1911063,0.0008180746,0.04810182,-0.034487046,0.045423258,0.021144116,0.025999064,0.04695703,0.017497277,0.05263153,-0.0010103806,-5.086804e-05,-0.023389397,0.098954536,0.05026307,0.03522522,0.07348992,-0.017927103,0.09903964,-0.005455295,-0.01352273,0.006763065,-0.0044672973,-0.0590584,-0.000367397,0.082673654,0.009127792,-0.03177472,0.02651246,0.008968995,-0.032903075,0.019010287,-0.099321365,0.13536958,-0.019884467,0.025954597,-0.08051272,0.055236153,-0.024491012,-0.06602738,0.04099023,-0.05188949,0.004717298,0.012408162,0.018758541,-0.012832506,-0.0030615253,0.0507754,-0.03656231,0.015637316,-0.018663377,-0.035600025,0.000310047,-0.0043859472,0.07844323,-0.0114241615,-0.051789023,0.004120779,0.030295165,0.019273577,-0.0053211,-0.023285016,0.013780244,0.00078791985,-0.03358693,-0.049856346,0.041192066,0.007385028,-0.0012830173,-0.036623955,0.044940203,0.021356009,0.026378976,-0.06417684,-0.010486049,-0.08541964,0.08219522,0.12196039,-0.0012682203,0.029015958,-0.045004908,0.026713578,-0.02959225,0.058379784,0.071936116,-3.1499837e-08,0.038924497,-0.06509512,-0.03207105,-0.052635614,-0.043807097,0.08342646,-0.049581442,0.020206753,0.01793454,0.06546205,0.029042974,-0.0024601026,-0.013578837,0.025352212,0.020767795,-0.009926917,-0.09603208,0.05334304,0.027220609,0.016894057,-0.10168117,0.03291239,-0.11609351,-0.0143856285,0.04599806,-0.033659447,0.004078587,0.031036558,-0.072118334,-0.032369852,0.056474444,-0.03480462,0.029360335,-0.019063475,-0.016405888,0.095023386,-0.0006170093,-0.014842362,-0.017617807,0.012952795,0.012346074,-0.012650319,-0.072863966,0.025318692,-0.05791626,-0.044567857,-0.06311312,0.08666676,0.002614357,0.043797575,0.00818766,0.019251686,0.032914605,-0.07783963,-0.038024146,0.024514526,-0.037497837,-0.06264943,-0.009727618,0.00604471,0.09634894,0.00059725746,0.038918097,-0.046119586 +2.1.1.191,The enzyme specifically methylates cytosine1962 at C5 in 23S rRNA. ,384,1.0,-0.045165647,0.005664853,-0.065963924,-0.05657726,0.01105307,0.056962226,-0.10182602,-0.013684742,-0.031800624,-0.02290474,0.015161453,-0.04611013,-0.02580339,0.0019140776,-0.04894675,0.023849137,-0.10138135,-0.047014546,-0.007501452,-0.028288526,0.019312512,0.07511899,-0.037671417,0.007107043,-0.024325976,0.006686672,0.029226521,-0.0012047815,-0.008802593,0.017893188,0.0110678,0.05755569,-0.0035699804,0.018795148,0.01742938,0.06459611,-0.070209265,-0.02895623,0.049316373,-0.036613323,0.087487966,0.07101355,0.036581796,0.031592123,-0.0012204559,-0.03889041,0.05834645,-0.022190183,0.01774939,-0.010579491,-0.027487678,-0.09765158,0.023847366,0.01788444,0.021856928,0.024749115,-0.061269578,-0.023233663,0.0058899214,-0.026787957,0.055955056,-0.05121701,-0.035770547,-0.06273046,0.034480583,-0.030636244,0.048803966,-0.036902994,-0.027711365,-0.044438202,-0.06944945,-0.032389104,-0.025529515,0.030330068,-0.055054087,0.023403326,0.08600282,-0.10444969,0.009545974,-0.031282064,-0.024123002,-0.015213552,0.036656763,0.02307775,0.023307808,0.0032741125,0.075131655,0.07286812,0.05021987,0.017387096,0.015868733,0.03805767,-0.04925915,-0.04218308,-0.10915757,0.0015321133,0.057541747,0.03247793,0.08344932,-0.028119193,0.0976531,0.13069881,-0.04002434,-0.03602143,-0.029053178,0.03459259,-0.011671704,0.10056909,-0.034629326,-0.019754216,0.020660017,0.09675636,-0.02010391,-0.010880991,0.035305068,0.05472676,-0.017805316,0.020959802,0.017633792,-0.011562225,-0.036776055,0.010333613,0.025770865,-0.016439272,-0.07275763,-0.013083613,-0.17416264,1.3419065e-33,-0.040655907,-0.0042667016,0.0189859,0.053048212,0.030665824,0.050678425,-0.007896202,0.00671722,-0.02509195,-0.070984416,-0.09620579,-0.1038673,0.060881056,-0.054440416,-0.04075689,0.044841975,-0.049635857,-0.030006774,-0.033419646,-0.0640321,-0.011079507,0.05315069,-0.053665273,-0.10556974,0.01446073,0.00407021,0.03896272,-0.015112082,0.11853353,-0.036232896,-0.04919729,-0.043602068,-0.042550273,0.030442014,0.14359526,0.09301548,0.025018947,0.032137927,0.036390595,0.044166077,0.05940798,0.0016569506,0.0186614,-0.02164997,0.032622803,-0.039249055,-0.06814481,0.060271785,-0.004519304,0.038185216,0.030922944,-0.012076084,0.059370834,-0.02083356,-0.06593747,-0.018754665,-0.026017584,0.007041524,-0.026600165,0.054678936,0.008183894,-0.029262723,-0.0048596147,0.08840786,0.014613828,0.0044616726,-0.07964852,-0.076609515,0.032583192,0.112286225,-0.023497317,-0.026489152,0.16578405,-0.051900864,0.03766323,-0.0035564383,-0.05482844,-0.028481932,0.033326034,0.085711494,-0.026862515,-0.0029902935,0.00076199515,-0.02614893,-0.026497973,-0.005928664,-0.0007106842,-0.037704308,0.02800832,0.08405134,0.09816223,-0.12741438,-0.039890464,-0.016134713,-0.04880612,-2.9309986e-33,0.08634646,-0.03838516,0.07617991,-0.059110966,-0.012014515,-0.020824686,0.045525704,-0.039552674,-0.07363874,-0.1308749,0.1431583,0.006053431,0.018349092,0.048168976,0.027442614,0.013436776,0.017267093,0.09810699,0.005414643,0.04710819,-0.018384805,0.0024000686,-0.05185197,0.08508597,0.034295026,0.011952297,0.030826261,0.017030843,0.081054874,-0.040593773,-0.06902639,0.009220641,-0.011840546,-0.058649547,0.01348905,0.06813626,-0.006960882,-0.073810875,-0.008655697,0.04272051,-0.027900157,0.049750607,-0.05701551,0.14926863,-0.04047016,0.03332512,-0.031986933,0.006056436,-0.022789638,-0.00042684135,0.008981529,-0.07307671,-0.0032071206,0.038788702,0.06923919,0.0078027877,-0.0075487243,0.05136648,0.049279094,-0.023859123,0.0027298739,-0.037640955,-0.06357561,0.014802027,0.022239795,0.020112332,-0.02624541,0.019858455,0.00027003256,-0.0070080385,0.023831392,0.020832155,-0.0022719759,-0.021885335,-0.07120807,-0.09602808,-0.005338824,0.005446255,0.012290606,-0.06984903,0.059052978,0.020834161,0.014629788,-0.02543914,-0.025165642,-0.07907022,0.06947295,0.10147301,-0.02903716,0.0021283787,-0.030545786,-0.0033614975,-0.04425147,0.039892502,0.06534162,-2.3708873e-08,0.044257056,-0.09355574,-0.02532988,-0.06688716,-0.016839476,0.106996395,-0.031628214,0.0302857,0.038409162,0.046411455,0.0019316019,-0.0044669895,-0.0012690993,0.008466654,-0.051716756,0.017293219,-0.08485093,0.012099513,0.030726256,-0.0080293,-0.111123115,0.077596955,-0.07011213,0.02786375,0.0035286355,-0.00913166,-0.009498488,0.14696898,0.0044557108,-0.08331936,0.03174002,-0.053158585,0.06255601,-0.019230772,-0.038792334,0.0544164,0.056962296,-0.025231315,-0.0120245945,-0.03536781,0.032115933,-0.040968645,-0.08246787,0.009610235,-0.03847,-0.074381016,-0.052839972,0.072791204,0.0046026534,-0.01610038,-0.013721118,0.017716717,0.03632664,-0.058474585,-0.014204117,-0.013526792,-0.037666984,-0.032233447,-0.085237175,0.043620445,0.036501568,0.014613805,0.086539984,-0.09881198 +2.1.1.192,"Contains an [4Fe-4S] cluster [2]. This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the appended methyl group. RlmN first transfers an CH2 group to a conserved cysteine (Cys355 in Escherichia coli) [6], the generated radical from a second S-adenosyl-L-methionine then attacks the methyl group, exctracting a hydrogen. The formed radical forms a covalent intermediate with the adenine group of the tRNA [9]. RlmN is an endogenous enzyme used by the cell to refine functions of the ribosome in protein synthesis [2]. The enzyme methylates adenosine by a radical mechanism with CH2 from the S-adenosyl-L-methionine and retention of the hydrogen at C-2 of adenosine2503 of 23S rRNA. It will also methylate 8-methyladenosine2503 of 23S rRNA. cf. EC 2.1.1.224 [23S rRNA (adenine2503-C8)-methyltransferase].",384,1.0,-0.0118443705,-0.08725676,-0.15237255,0.043804035,0.091365375,0.061487503,-0.086272255,0.044403713,0.044054918,0.006255056,0.04717225,0.05229127,-0.041678622,0.08605874,-0.01902763,0.07751287,-0.10679237,-0.010903571,-0.014371112,-0.009176404,0.025268696,0.08989519,-0.02515247,0.037999548,-0.00023394675,-0.0139294965,0.11176613,-0.029658206,-0.043316454,-0.019858943,0.08697717,-0.011364108,0.05786684,0.024556672,-0.023998909,0.10627737,-0.017154053,-0.0001707123,0.089346655,-0.0061905966,-0.024560994,-0.003880128,0.07089727,-0.032520004,0.0062299483,-0.07105774,0.009628345,0.05195734,0.031486616,-0.015560885,-0.0012219518,-0.05188337,-0.019142112,0.02588032,0.07991485,0.05235018,-0.09072685,-0.07654994,0.039701305,-0.040441226,0.10393632,-0.032445002,-0.084045604,-0.06311151,-0.038398337,-0.048388798,0.055574514,-0.0501327,0.07484221,-0.025607234,-0.0019826456,-0.03192463,-0.028925324,-0.0017643273,-0.00089467416,0.019388398,0.03015011,-0.021991108,-0.00016816668,-0.031009866,0.06589785,0.020625535,0.060601458,0.013554232,0.08676821,0.04355561,0.010742301,0.05740237,0.038462356,0.00652869,0.009775272,0.032725208,0.03874724,-0.070992246,-0.020439228,-0.008326255,0.015381196,0.0016557309,-0.02898469,0.01491914,-0.01789652,0.08172575,-0.058912266,-0.047496807,-0.056635994,-0.0030775152,0.0030612105,0.11928978,-0.025011193,0.019145096,0.012396499,0.07819015,-0.011835879,-0.028420283,0.015190393,0.06655621,0.029266775,-0.07259122,-0.012745485,0.026127223,-0.011453981,0.024399318,0.02702601,0.054264367,0.005847793,-0.013848435,-0.15841976,4.7951677e-33,0.075661846,0.03332125,-0.0085355025,0.015771756,0.028643753,-0.024385666,-0.06752478,-0.008953432,0.051300682,-0.022212368,-0.0920345,-0.05260556,0.10284741,-0.039225813,-0.05439162,-0.020355886,-0.052771654,-0.032287773,-0.0018040406,-0.01316076,-0.10113693,0.009785013,-0.053888112,0.00049188954,-0.034195274,0.0127524445,0.047748227,-0.021372166,0.07920527,-0.0027136044,-0.06430062,0.007990291,-0.10734124,0.083765574,0.06977534,0.027583236,-0.048612803,-0.026545174,0.04483974,0.09406994,0.010735336,-0.00095484586,-0.016947407,-0.02347004,0.06390341,-0.046677027,-0.03015417,0.063427836,-0.0056839096,0.094055906,0.08489903,-0.0086219795,0.090411566,0.00051396916,-0.09406687,-0.0735359,-0.006124343,-0.0012860802,0.027889566,0.041914843,-4.632652e-06,-0.03612454,-0.050762407,0.051119365,-0.023562774,-0.0018638555,-0.07046474,-0.13011472,0.033208173,0.040340956,0.0072006388,-0.0045011872,0.13635589,0.017021125,0.00013694861,-0.012065834,-0.010805149,0.08840669,0.048631154,0.07440668,-0.029187925,-0.005336402,-0.026065,-0.026403561,-0.030789243,-0.011802412,0.015892036,-0.10283844,-0.04083646,-0.02619861,0.0007395554,-0.11346438,-0.029737143,0.02827309,0.043427315,-4.3457876e-33,0.06735619,-0.054673836,-0.009505747,-0.06278536,-0.030931916,0.03388378,-0.00833534,-0.05114637,-0.020615643,-0.16087049,0.10208166,-0.019408394,0.033042304,0.02998415,0.09760295,-0.032088365,0.0035168598,-0.002213859,-0.0035531842,-0.006519491,0.02734333,0.033035196,-0.012500387,0.046008732,0.06266714,-0.007995087,0.011226744,0.06801549,0.092317,0.044427026,-0.023285266,-0.023860814,-0.045410853,-0.0007144044,-0.024842437,0.13731106,-0.018668318,-0.009711013,-0.015886145,-0.015299234,0.03303256,0.017738884,-0.042349562,0.12920883,0.0010333783,0.06484543,-0.0061973627,0.0066060605,-0.029874165,-0.12810238,0.062646165,-0.029510887,0.014109854,0.0020873891,0.018624805,0.061007958,0.025356455,0.03918247,0.021448225,-0.05113592,-0.054595727,-0.03753181,-0.00397363,-0.010785609,0.0069161863,-0.037746098,-0.017471263,-0.018477004,0.0041883546,0.024785243,-0.004760012,0.004491303,0.047096673,0.065511174,-0.035188563,-0.088650346,-0.066807605,-0.04589622,-0.018943142,-0.010851714,0.006421262,-0.06027625,0.004222317,-0.044349607,0.03117441,-0.04963695,0.060461883,0.08969004,-0.009513316,-0.005221877,-0.004591459,0.011592507,-0.02368699,0.07302509,0.04549411,-5.2368446e-08,0.056350514,-0.0946803,-0.0031390812,-0.0997968,0.05730088,0.10151633,0.03781566,0.016767956,-0.032189786,-0.017024105,-0.034410648,0.0675589,-0.053081926,0.024180835,-0.020594437,0.041963793,-0.061319925,-0.004192529,0.00045085448,-0.041796006,-0.0709353,-0.0073578474,-0.07121012,-0.0066456194,-0.020643586,-0.008025286,0.04043441,0.06974668,-0.011484657,-0.0546968,0.07446901,-0.0059928135,0.03995447,0.030554764,-0.14394958,0.020379988,0.027921202,0.008235105,-0.013027345,0.022754472,-0.0075314124,0.002233593,-0.08653637,0.040176783,-0.048514128,-0.05479442,-0.03626299,0.05848375,-0.023165585,-0.039970867,0.027310463,-0.012305127,-0.01302484,-0.04605139,-0.081629395,-0.038592473,-0.054229796,-0.058670633,0.046860453,0.006346467,-0.035567276,0.030177288,0.0855421,-0.01694611 +2.1.1.193,The enzyme specifically methylates uracil1498 at N3 in 16S rRNA.,384,0.99999994,-0.033681866,-0.00025304197,-0.120196395,-0.063209146,-0.022773724,0.012459969,-0.10418769,0.0101784235,-0.017133696,-0.036720198,-0.0024014069,-0.025186501,-0.045598138,0.0876171,-0.04351312,0.035666633,-0.084261306,0.0013483397,0.01944716,-0.026232008,0.10276912,0.06844151,-0.034152754,-0.01432188,-0.0029683902,0.021327091,0.07899409,-0.054716635,0.0057651885,-0.048520423,0.02221102,-0.004981984,0.013670437,-0.07372083,0.07826653,0.04033566,-0.08615004,-0.05056412,-8.284598e-05,0.016000012,0.07063911,0.05871084,0.019059667,-0.009245092,-0.03505945,0.010314086,0.043781165,-0.019737415,0.047187008,-0.028235402,-0.027750056,-0.06666543,0.0040601417,0.05260124,0.07726573,0.0063528297,-0.10113961,-0.05514922,-0.036970522,-0.027489284,0.030572684,-0.057175305,0.0034931363,-0.074704096,0.038595635,0.03578962,0.009385272,-0.051940337,-0.03128822,-0.05246035,-0.052200835,-0.034937546,-0.06135052,0.07264016,-0.028802102,0.027172314,0.093693696,-0.05023905,0.046377014,-0.05401976,-0.011137893,-0.039114233,0.015057582,0.00925879,0.046488166,0.029321948,0.025324188,0.02997303,0.03709763,0.041501734,0.030888813,-0.0011524758,-0.01212328,-0.016414203,-0.038641095,-0.0015186956,0.024509976,0.008825122,0.001730726,-0.02784401,0.076145895,0.1076879,-0.085893214,-0.031949375,-0.07010388,0.03571578,0.029668285,0.09499749,-0.032179654,0.021671895,0.041838717,0.0834976,0.044966508,0.009094784,-0.05150826,0.02680177,0.018524999,-0.06691471,-0.057648376,-0.0011494843,-0.046491873,-0.0127032325,0.0472292,-8.938801e-05,-0.04461306,0.007570924,-0.08889481,1.2514643e-33,-0.003019469,0.026990106,-0.042350497,-0.057592787,0.05828077,-0.0018661022,-0.004895462,-0.009199456,0.0042402297,-0.1257144,-0.090435624,-0.09568288,0.0055662603,-0.054296605,-0.1250577,0.040303808,0.0057339296,0.040199455,-0.032999318,-0.05609032,0.00021347794,0.08910704,0.0006836048,-0.030205285,0.0052306973,0.024402678,0.009448447,-0.01255145,0.08022662,-0.035143573,0.042040754,-0.05837088,-0.1138662,0.03932247,0.094065934,0.06773304,0.042775597,-0.045530085,0.013099801,0.06670628,0.037780777,0.046352092,0.034361586,0.01240045,0.013616326,-0.040931087,-0.06784246,0.05002792,-0.01608545,0.0778478,0.023695566,0.056586668,0.045068007,-0.04653815,-0.08372801,-0.059891578,-0.039529648,-0.051149804,0.016729,0.023171432,-0.014025668,0.0054355282,-0.013867592,0.034224242,-0.006505241,0.008132448,-0.058695417,-0.066916734,0.039395563,0.06273996,0.009528488,-0.020960221,0.1317858,-0.027525656,0.029177748,-0.044320833,-0.07932939,-0.026361877,0.05226242,0.065533236,0.0114007,0.017746666,0.02115655,-0.0073695565,-0.08514859,-0.050551087,0.06771105,-0.062395234,-0.0016600817,0.03500413,0.0830061,-0.034823567,-0.020831587,-0.005084698,-0.0033522055,-2.0228517e-33,0.117757425,-0.10607431,0.1237473,-0.035264987,-0.010175313,-0.0056951684,0.040524773,-0.014906416,-0.024064904,-0.06872813,0.1623084,0.0044547236,0.071935125,-0.052298818,0.037116967,0.018279947,0.035019487,0.07655544,-0.00892868,-0.027873676,-0.021172246,0.05157787,-0.05276616,0.11954595,-0.0022390783,-0.016402656,0.045919918,-0.011460046,0.0685875,-0.03141422,0.014605166,0.0064138826,-0.018170225,-0.019334689,-0.015642133,0.09493984,0.02510369,-0.00068284385,-0.02385699,0.0031044928,0.03842614,0.021214526,-0.044386562,0.09870139,-0.061597742,0.04088437,-0.069788136,0.008913303,-0.006061096,-0.012357477,0.06747676,-0.021655522,0.046086174,0.04633985,0.08284749,0.007635916,-0.024239298,0.06526411,-0.014428856,-0.013217866,-0.016057925,-0.046586443,-0.021364368,-0.014357102,0.017051553,0.012105021,-0.09418627,-0.03682419,0.018819064,0.005934269,-0.008888626,0.0007792833,0.026647838,-0.016302431,-0.032747973,-0.10624814,-0.03849575,-0.04859761,0.00912394,-0.10581063,-0.007836406,0.00010065961,0.036586817,-0.018973665,-0.005522783,-0.053140823,0.0930271,0.10729489,-0.032920755,0.022330109,-0.034272525,-0.041514423,-0.111058205,0.057264443,0.084123604,-2.3922189e-08,0.032065984,-0.069763586,-0.0019518515,-0.04439334,-0.025592636,0.09361873,-0.022455838,0.0526535,0.05838833,0.054009706,0.06892259,-0.0052211625,-0.015338774,0.0067771063,0.048375417,0.014394305,-0.021141822,0.03594509,0.02749979,-0.016093163,-0.09355413,0.09335456,-0.06407247,-0.009192047,0.036049575,0.007838126,-0.017244488,0.08966121,-0.041291967,-0.07506386,0.07827857,-0.023334324,0.08502176,-0.045126002,-0.05554948,0.049123388,0.05589388,0.023655113,0.02268763,0.010292579,0.007388122,-0.02291926,-0.061631095,0.021236083,-0.072237745,-0.048278857,-0.06284584,0.033064485,-0.053232837,0.0007533643,0.093119495,-0.016197588,0.042112205,-0.10120973,-0.0271174,0.0025361911,-0.050505385,-0.06743383,-0.046737246,0.059829507,0.11517221,-0.024102187,0.082863726,-0.046090685 +2.1.1.194,Contains an [4Fe-S] cluster [1]. Cfr is an plasmid-acquired methyltransferase that protects cells from the action of antibiotics [1]. Cfr methylates position 2 of A2503 after the primary methylation at position 8 is complete [2]. cf. 23S rRNA (adenine2503-C2)-methyltransferase (EC 2.1.1.192).,384,0.99999994,-0.057044998,-0.032299656,-0.093103155,-0.032613367,0.07122969,0.04456696,-0.10190841,0.06566201,0.07061322,-0.066142656,0.03974621,-0.05842701,0.012972503,0.0719062,-0.08512958,0.008034229,-0.09825658,-0.035654515,-0.01996341,-0.047981557,-0.10949139,0.14003175,0.016622206,0.041031763,-0.045630876,0.071037225,-0.024547718,0.0071945437,0.05752254,0.016430281,0.05008924,0.055127013,0.06941223,0.010067434,0.024624694,0.03831895,0.015356859,0.0022244703,0.07969017,0.026380233,-0.011151546,-0.028613709,0.04853417,0.017652297,-0.036769714,0.0018011509,0.007974487,0.04135396,0.007988345,0.00055381673,0.037479118,-0.012405426,-0.07427997,0.060190905,0.10863155,0.03984091,-0.056234576,-0.1283416,0.006881877,-0.009988501,0.0631304,-0.050663427,0.01683469,0.012704854,0.013943387,0.01801792,0.06968115,-0.04478845,0.0007904316,-0.055447605,-0.048798107,-0.08017486,0.013717607,0.07201197,-0.010395209,0.03962142,0.011061328,-0.05837247,0.05817168,0.00646837,0.056387495,0.0050438927,0.051748984,0.043354638,-0.032753304,-0.054054853,0.040204264,-0.05479607,0.057638634,0.043628126,-0.050996374,-0.015848769,-0.019208724,-0.03973936,-0.12119035,-0.009465722,-0.018563105,0.038277984,0.068421416,-0.0146353785,-0.0007628907,0.022524623,-0.044267915,-0.033625804,-0.13703188,-0.015037422,0.05584706,0.068145126,0.0060631684,0.030629985,0.05970023,0.12492798,-0.032354545,-0.036410566,-0.023868574,0.0525157,0.034767743,-0.030544158,0.07700216,0.05699599,-0.060646016,-0.06452936,0.010004792,-0.031741884,0.02464084,-0.086609215,-0.16803421,1.5319324e-33,-0.021546237,-0.011492878,0.047193415,0.006150132,0.045541253,0.009013771,-0.023457183,-0.019675862,-0.014287789,-0.024014927,-0.049044795,-0.06543831,0.020226287,0.019185176,-0.0052784234,-0.086821645,-0.055004966,-0.05107133,-0.07464322,-0.067574,0.012354283,0.053958897,0.013645551,-0.06345044,0.080803394,-0.037329994,-0.005056817,-0.00087436347,0.16886775,-0.029385332,-0.024035187,-0.033532187,-0.082946025,0.005815795,0.017915027,0.033615105,-0.010768158,-0.042422675,0.02063481,0.077310055,-0.0016905798,0.008087626,-0.05325746,-0.002016443,0.08421852,-0.036195986,-0.076331824,0.045792732,-0.028038463,0.019695595,0.0685849,-0.027854556,-0.046793967,-0.048903782,-0.03241262,0.0057894266,-0.10136763,-0.019570136,-0.06969336,0.06299068,0.021814944,-0.010964856,-0.059466433,0.0017113795,0.046528894,-0.025575679,-0.020191189,-0.052733004,0.020730635,0.065204695,0.0026617462,0.019499833,0.104366794,0.013890031,0.05354742,-0.031480107,-0.047305364,0.059929345,-0.0098903375,-0.023142671,-0.062587254,0.03294094,-0.020640489,0.063406505,-0.10231544,0.0024485285,0.013166486,-0.054486044,0.0042805155,-0.035347387,0.0508871,-0.069491014,0.01899874,0.005206613,-0.053405765,-3.3194337e-33,0.05130406,-0.07394895,0.062110037,-0.082795955,-0.02774419,0.026481573,0.018287256,0.04460131,0.014286683,-0.07799762,0.103329465,0.07117692,0.032371018,-0.050407168,-0.017474039,0.038158648,-0.025024235,-0.01161563,-0.08738668,0.023301184,0.060439028,-0.0063367803,0.059882164,0.06924961,-0.012687457,0.042843446,-0.028023336,0.033175483,0.06550612,0.06832461,-0.032062203,-0.009663804,-0.017430667,0.007829714,-0.027937803,-0.010734068,-0.014813383,-0.035990752,-0.0321815,-0.019372417,-0.032039504,0.09659125,-0.07681131,0.14337072,-0.0076386463,0.0674794,0.03545505,-0.012151018,0.052516337,-0.07146477,-0.040255222,-0.0392232,-0.0077932063,0.043150783,0.04099907,0.0358452,0.043004423,-0.053432107,0.033234872,-0.0043240506,0.0035079143,-0.045014158,-0.013722681,0.028117696,0.077450335,-0.018517712,-0.04053566,-0.025675382,0.021763563,0.08201182,0.060156267,0.0016333698,-0.03201285,0.043458052,-0.01380659,-0.0015936429,-0.012519186,-0.06282249,-0.084523216,0.053008184,-0.013829954,-0.024659446,-0.051693242,-0.027894882,0.03774493,-0.06592665,0.092982434,-0.002411391,0.0063974974,0.011911211,-0.007029735,0.0034347742,0.021766197,0.0013193099,-0.028419789,-4.146438e-08,0.00428018,-0.11158269,-0.062458,-0.04186,-0.028660482,0.09745974,-0.04914006,-0.051812164,0.03586982,0.012388825,0.025177445,0.013809411,-0.04782872,-0.015793355,0.0661953,0.012272803,-0.015187397,0.024432322,0.0006407451,-0.07895687,-0.093325265,0.02009702,-0.020015609,0.019272355,-0.0023135913,-0.00047206183,0.047636345,0.06045583,0.014584259,-0.0587865,-0.007096573,0.04050306,0.066256545,-0.00714717,-0.03793319,0.07525226,0.040349565,-0.023848059,-0.006103068,0.075463,0.030790765,-0.0037628,-0.09434078,0.022398172,0.050350457,0.0038714316,-0.03183091,0.044021383,-0.045329425,-0.080633685,0.09406118,-0.013782113,-0.00016201648,0.047346443,-0.07250798,0.0036942565,-0.16385241,0.02812781,0.011488991,-0.053276394,-0.042166185,0.034478854,0.072150685,-0.0102569 +2.5.1.90,"This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate, the isoprenoid side chain of ubiquinone-8 and menaquinone-8. The enzyme adds five isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry",384,1.0,-0.069226325,0.011800423,-0.037648134,0.010353892,-0.025145672,0.04007531,-0.057812557,0.05572382,0.0378419,-0.041066255,0.027954374,-0.021672431,-0.07114425,-0.00509124,-0.043296993,0.040058475,-0.07841967,-0.0031880476,0.045866083,-0.039921947,0.071982905,-0.03504559,-0.05481267,-0.045622073,0.03264134,0.03577005,0.09075984,0.0010840984,0.02604851,-0.05601672,0.010168112,-0.05129869,0.020622693,-0.09205723,0.036551286,0.1004583,-0.004210213,-0.039849002,-0.0031003975,0.051356312,0.04427987,-0.088337384,0.004999653,0.035671655,0.0127635775,-0.017464355,-0.0062666344,0.12294869,0.069972284,0.03381826,-0.018092899,-0.044606574,-0.041331302,0.033638787,0.03664532,-0.010062331,-0.05749017,0.010663537,0.0017585511,0.017722927,0.023437038,0.04104529,0.010782911,-0.017537607,0.08970829,-0.03888785,-0.016964683,-0.012045021,0.053736396,0.034336116,-0.034574263,-0.016999597,-0.091064565,-0.0019911036,-0.030688081,0.022977572,-0.067064725,-0.02156779,0.03453264,-0.06233291,0.07077902,-0.011084041,0.029897569,0.045099672,0.0022361644,0.011606305,0.008647802,0.015032161,0.059838966,0.043811068,-0.016324423,-0.028923629,-0.01594355,-0.052823458,-0.06730432,0.028601615,0.0030880652,0.09039447,-0.026256831,-0.017014068,0.06923462,-0.0033956887,-0.10815407,-0.12209588,-0.03368405,0.031487495,-0.0018143537,0.028164137,0.03212663,-0.018306078,-0.05987103,0.025953587,0.008597662,-0.05736146,-0.054418422,0.04292663,-0.0044746837,-0.0183352,-0.07409843,0.013714803,-0.080618165,0.07318499,0.025953686,0.07951477,-0.01667596,-0.004113043,-0.10877372,4.0762294e-33,0.06257724,0.061692055,0.03147271,-0.022956176,-0.07011473,-0.04932342,-0.06319264,0.03661609,-0.1209793,0.027690131,-0.025174,-0.029767742,0.029876927,-0.0052230004,0.0223968,-0.058325626,0.060645413,0.018207632,0.08935197,-0.07619164,-0.07592146,0.042352367,-0.03648488,-0.052591916,0.026395785,0.06308855,-0.018729975,0.03185692,0.035855465,-0.025415422,0.015836783,-0.035622247,-0.116883166,-0.017081786,0.053486254,-0.085557394,-0.073721334,-0.030785471,-0.035043694,0.014319859,0.034792103,-9.187426e-05,-0.07881987,-0.021903343,0.08339024,-0.028143434,-0.051546697,0.08718212,0.11888786,-0.022873426,0.04048598,0.029303063,0.049072716,-0.017701542,-0.08718011,0.0297841,0.0027728647,0.01924504,0.046241604,0.0087364055,0.007945985,0.043423925,-0.03434413,-0.013023974,-0.028980937,-0.013641324,-0.04292061,-0.044439957,0.014467183,0.08693243,-0.039364424,-0.034890797,0.04175338,0.05148203,0.03914328,-0.018295052,-0.08961126,-0.019536762,0.07118387,-0.024173085,-0.020800542,-0.019463837,0.013214936,-0.07392327,-0.05338733,0.03935139,0.025597567,-0.040892556,-0.034010947,0.1002328,0.02994628,-0.08666941,-0.06022465,0.018265313,0.06558489,-6.187178e-33,0.057622753,-0.091685124,-0.03129834,-0.15098844,-0.036906578,0.0012865451,0.043939393,-0.025614602,-0.012622601,0.04488408,0.095677204,-0.011485068,0.034046944,-0.011250469,-0.021339377,-0.00062212255,0.027962146,0.09272275,0.07440906,-0.05307151,0.018045051,0.08644867,0.036603812,0.061043907,-0.026414866,-0.021166194,0.08524403,0.06340971,0.054050546,0.14128622,0.026137007,-0.023617582,-0.043351546,0.03192861,-0.02954903,0.042288672,-0.045904495,0.052277002,0.07007219,-0.018732281,-0.021180274,-0.039330695,-0.029336998,0.026580432,0.0697089,0.08943451,-0.06348886,0.033274997,-0.12928554,-0.08962113,0.065434426,0.031089209,-0.058389988,0.0018782952,0.013989652,0.03341224,-0.06890495,-0.062605016,0.081975505,-0.042665727,-0.03156326,-0.06668336,0.031355586,-0.081167825,0.031535495,0.10744646,0.013361629,-0.002684636,-0.0407834,-0.04410841,0.089748956,-0.022607831,-0.0063178935,0.050602846,-0.00046928506,0.01974852,0.032996677,-0.02325563,0.017769126,-0.065198526,-0.059689097,-0.055729784,0.017876826,-0.014157653,-0.052367162,-0.046446063,0.09244408,0.08263763,-0.0050192624,0.14713259,0.008418288,0.023485929,-0.033800405,0.02546968,0.08136219,-3.3534988e-08,0.02666523,-0.06790287,0.11037231,-0.05099469,-0.019748947,0.001179457,0.0016144083,0.025977086,0.030410452,-0.009856954,-0.031471312,0.009486419,0.047461398,0.029006595,0.08811565,-0.005546008,0.010405697,0.06022998,-0.02420677,-0.048167616,-0.056062426,0.029855113,-0.022402178,-0.04120747,0.007856108,-0.042841714,0.06882214,0.027407946,-0.03937775,-0.031371962,0.071234025,0.05521772,-0.053035323,-0.05278941,-0.03744387,0.07443629,-0.014485165,-0.01988524,0.012333585,-0.025351156,-0.06654263,-0.037972614,-0.07068855,0.045196764,0.016665049,0.0070852255,0.027365454,0.043396994,-0.041022226,0.009323743,0.018548945,-0.04849637,0.014302988,-0.07656215,-0.021987796,-0.055751946,-0.05925059,-0.057193596,-0.04465674,-0.066382125,0.024790674,0.017073995,0.12602633,-0.0727322 +2.5.1.91,"This enzyme catalyses the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10. The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.",384,1.0,-0.07227801,0.005959265,-0.03872012,-0.023157552,-0.01664436,0.033014238,-0.030654876,0.055051763,0.012353424,-0.036670357,0.044252567,-0.02173697,-0.07055356,0.0074674925,-0.038894907,0.0046250937,-0.07306848,0.003201839,0.06565478,-0.055427745,0.061652485,-0.013882378,-0.06007125,-0.045289136,0.046528395,0.013477268,0.075059414,-0.0008311288,0.035245765,-0.060110863,0.023313351,-0.07719966,0.021594983,-0.04536284,0.012988753,0.062004004,-0.02377511,-0.028226247,0.008205891,0.05689265,0.054410536,-0.08111352,0.018222637,0.02737433,0.009497102,-0.022781493,-0.04745133,0.12619366,0.060922034,0.04260347,-0.013650162,-0.010660407,-0.039611567,0.03677849,0.024927668,-0.012896839,-0.055865623,0.014877635,-0.030331422,-0.011064708,0.03205944,0.035916824,-0.023313634,-0.042680006,0.08052823,-0.00045907233,-0.034863494,-0.015647812,0.07213124,0.023680018,-0.02140841,-0.052412383,-0.08105148,-0.042536303,-0.08065267,0.04354962,-0.07027009,9.561058e-06,-0.007125674,-0.05839952,0.08023089,0.008039637,0.052296408,0.022431493,-0.01804416,0.01938332,0.02607592,0.024299422,0.04293804,0.05048927,0.0003804981,-0.044229697,-0.0042889183,-0.028892059,-0.07444161,0.052435473,0.014801576,0.113098934,-0.028639428,-0.019925868,0.061564837,0.05105029,-0.079603665,-0.16368882,-0.03902389,0.041250046,0.020920282,0.016171062,0.044046137,-0.027155582,-0.06057943,0.036978252,-0.011816646,-0.033620663,-0.038291708,0.038201466,0.015392455,-0.012991366,-0.085728794,-0.0033678878,-0.053342044,0.051971585,0.016403975,0.07293113,-0.028398998,0.003457086,-0.10170013,3.8617223e-33,0.048552535,0.035701063,0.023038289,0.0025155847,-0.0618352,-0.020356674,-0.08449529,0.06829151,-0.12933457,-0.005645469,-0.020076618,-0.050689895,0.022065427,0.0152756,-0.007245778,-0.06924625,0.047868244,0.015417072,0.09662006,-0.074840546,-0.068451606,0.05397697,-0.052127026,-0.056619707,0.013544763,0.056748677,-0.06829921,0.06323101,0.036802504,-0.014902051,0.022294473,-0.0422433,-0.09976571,0.014189806,0.05908001,-0.055153318,-0.06569369,-0.028723404,-0.01165724,-0.006807716,0.02363967,-0.01878112,-0.085827604,-0.016985834,0.08852378,-0.053553294,-0.008013522,0.09119302,0.07283152,-0.04409843,0.008734951,0.043652024,0.033241097,-0.027813066,-0.0561775,0.03145707,0.02742552,0.019427482,0.03894095,0.018183628,0.03483023,0.0400256,-0.06893117,0.01260533,-0.013245608,0.009406977,-0.018778322,-0.023208827,0.023410223,0.11794805,-0.046419475,-0.044027627,0.036109503,0.048774272,0.039427888,0.002154348,-0.036779173,-0.038797114,0.058273975,-0.046241473,-0.039303355,0.005497107,-0.018543828,-0.06042217,-0.038490396,0.04049728,0.0050965725,-0.053144794,-0.034318093,0.108136505,0.027929852,-0.067210704,-0.049295433,0.01920043,0.06855762,-5.4210883e-33,0.073128305,-0.12388063,-0.06184681,-0.13463865,-0.07425539,0.03272593,0.07508191,-0.02679247,0.00034168,0.045148265,0.101942696,-0.027910871,0.0145221185,-0.034230653,-0.02946339,0.02329053,0.04501955,0.08383653,0.057256218,-0.052152686,0.035672206,0.12434168,0.040527273,0.02802599,-0.039326545,0.026568493,0.10092746,0.067444734,0.036327202,0.14172405,-0.011464823,-0.032975446,-0.04199831,0.0033629937,-0.061112113,0.04463603,-0.048021384,0.038727168,0.058195252,-0.04159998,-0.033032335,-0.014700514,-0.03146674,0.004480232,0.09359569,0.06763781,-0.08627124,0.007192723,-0.11414815,-0.11325332,0.07609853,0.036841016,-0.037450064,0.026787573,-0.004080225,0.042207297,-0.06321643,-0.04206693,0.080764025,-0.04372138,-0.054435384,-0.06710087,0.017908866,-0.085108116,0.04243,0.061015002,0.020647427,0.014372646,-0.017979925,-0.048066523,0.07546502,-0.02149387,0.0149118025,0.046608288,-0.03476834,0.013968441,0.029812405,-0.020496493,0.0082787955,-0.0760597,-0.03833916,-0.04234012,-0.025035836,-0.0212002,-0.02899106,-0.038619656,0.057879806,0.104338646,-0.012473696,0.14490604,0.016728284,0.03229983,-0.028497381,0.029548224,0.09659513,-3.2939013e-08,0.02837777,-0.051224254,0.1128237,-0.040765125,-0.002884053,0.027000828,-0.003071375,0.017169274,0.010288454,-0.0055832644,-0.014922,0.009810438,0.02949371,0.054811742,0.08005044,-0.0040389886,-0.006972309,0.05144114,-0.02379755,-0.062310867,-0.061228953,0.04684897,-0.046488646,-0.04377291,0.0003648537,-0.023761205,0.08808527,0.027462997,-0.0441701,-0.019406313,0.06062295,0.021101931,-0.041502982,-0.046558842,-0.023343666,0.08654985,-0.0007979272,-0.036972824,0.042956218,-0.03296278,-0.06452401,-0.011495677,-0.060574707,0.063018605,-0.013366948,0.0046807807,0.03375266,0.072375104,-0.05738654,0.022491314,0.03368793,-0.03367789,0.006826555,-0.07026286,-0.035796426,-0.02470767,-0.04091878,-0.06054508,-0.044612084,-0.039467566,0.015911635,0.036656823,0.113151096,-0.060528744 +2.5.1.92,"This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase]. ",384,0.9999999,-0.08151698,0.0065523754,-0.042229094,0.012077232,0.01630726,0.010793622,-0.052184068,0.031357713,0.017653584,-0.030550115,0.046907775,-0.038408972,-0.017282197,-0.025477964,-0.061211526,0.012633284,-0.028917827,0.02547867,0.005644316,-0.041371256,0.04593723,0.10497534,-0.01358679,-0.023906836,0.049375035,-0.047942404,0.014556336,0.014167135,0.03984305,-0.09507484,-0.077488996,0.0073621063,0.0060929866,-0.014375519,0.056564588,0.015702218,0.03644064,-0.07810792,0.016567424,0.04445329,0.098986745,-0.018370045,0.01276007,-0.06420553,-0.008964991,-0.015690101,-0.04146343,0.0032151488,0.0023072492,-0.031055981,-0.048144836,-0.07727984,-0.030475866,-0.06176557,0.03671459,-0.017605836,0.01717526,0.0035514564,-0.02372705,0.058872,0.069325276,0.00082666625,0.007104978,-0.029809974,0.026995314,-0.06439344,0.014696115,-0.049934883,0.055316627,-0.10860203,-0.17049262,-0.0835752,-0.041562747,0.026329689,-0.07806211,0.053515732,-0.008395814,-0.011435056,0.033897836,-0.062080752,0.054758206,-0.04979121,-0.025199566,0.025425632,0.023564959,0.020097475,-0.050542668,0.036110617,0.07422445,0.056424458,0.030805465,-0.0425642,-0.048481803,-0.049764283,-0.07473374,0.059050344,0.03726947,0.01708954,-0.01651674,-0.021861399,0.06562144,0.025466029,-0.015678454,-0.060768306,0.030321848,0.015606274,-0.048292696,-0.037057117,0.0008145005,-0.029082647,-0.015047761,0.049763616,0.01517087,-0.031153796,-0.022918835,0.0509933,-0.002523874,-0.005754892,0.027079571,0.026114557,-0.0037210654,0.06108809,0.011819293,0.06824096,0.0030321057,0.070860766,-0.1356168,4.2603122e-33,0.01761235,0.11089392,0.018316975,0.022740254,-0.059320934,0.01125978,-0.035488583,0.10729145,-0.07861198,-0.023514109,-0.082922645,-0.09109931,0.12167592,0.014678876,-0.0045075906,-0.030300442,-0.007427449,-0.026288405,0.08240418,-0.028175214,-0.005254523,0.030853955,-0.061299287,-0.004618922,0.0118045835,-0.011301171,-0.038294762,-0.017357916,0.03596376,-0.02861063,0.070489965,-0.06974303,-0.037236206,-0.014095582,0.12329919,-0.085984215,0.028297596,-0.0411558,-0.057056297,0.0052286894,-0.023983479,0.015759397,-0.047325198,0.009443573,0.028375397,-0.0651834,-0.045321323,0.089309074,0.1049412,-0.016159557,-0.0011319123,-0.030093284,0.12346787,-0.008366316,-0.038462162,0.054471448,-0.018362015,-0.036566537,0.050273873,0.040601727,0.012935035,0.019129127,-0.11205936,0.009844158,-0.0061748736,0.05206893,-0.070713505,-0.036863852,0.013725113,0.12824237,0.018436864,-0.035479236,0.047885735,-0.024247117,0.031577166,-0.049868252,-0.07823437,0.014297415,0.02232315,0.043847483,-0.0015347633,0.0026750478,0.02303288,-0.05955993,-0.07607108,-0.04639293,-0.01824292,-0.007402369,0.035749067,0.059339866,0.107363835,-0.109738044,-0.06588756,-0.049553744,0.01539586,-4.0536045e-33,0.055874772,0.018937796,-0.028414706,-0.06347557,0.040365424,-0.072144315,0.040044814,-0.047546797,0.015603079,-0.011101047,0.06998972,0.004242792,0.112338364,-0.06855454,0.026100846,0.06171641,-0.03723512,0.09706129,0.06667074,0.011748452,-0.05216579,0.008661172,0.025625378,0.04966041,0.023516145,-0.023491299,0.0033992657,0.016457208,-0.060658507,0.07178876,-0.032049518,-0.022709401,-0.022943305,0.027476415,-0.033619292,0.04139917,-0.06623239,0.008783796,0.04742954,0.007822088,-0.066483945,0.06218798,-0.012160131,0.12564294,0.081426,0.05418794,-0.06524063,0.025627978,-0.071203776,-0.041291315,0.0058080675,0.044899248,-0.014064926,0.035454087,-0.0098320125,-0.032119762,-0.020228596,0.011982157,-0.03532504,0.012238652,0.047402617,-0.06326689,-0.0346409,-0.02314397,0.07864149,0.06734269,-0.025740746,0.07551559,-0.019082228,-0.0060073244,0.048891433,0.031438686,0.0069139376,-0.011692057,-0.056619007,-0.027079724,-0.026456738,0.010469608,-0.0308036,-0.0030567625,0.014309552,-0.03201839,0.024795176,-0.017112117,-0.038557272,-0.07250316,0.014123882,0.13744931,0.010399908,0.04350984,-0.05190412,0.00081810454,-0.028690355,0.101309575,0.12424561,-4.10306e-08,0.055221472,-0.11400203,0.028895592,-0.029885951,0.06604486,0.029431082,-0.03297498,0.01260152,0.063119926,0.033618324,-0.07923317,0.05546386,-0.0048396774,0.016846748,0.08241112,0.0008441795,0.008552841,0.0891776,-0.021180298,0.052908845,0.01464877,0.048343055,-0.12217389,-0.002065209,0.049264625,-0.057871684,-0.035166252,0.0029788895,0.07614787,-0.06832032,0.0365754,-0.020145338,0.0052843564,-0.06962471,-0.0985273,0.08033198,0.002399334,-0.05015734,-0.0065287566,0.055968147,-0.012097779,-0.040536225,-0.05487067,0.0046482235,-0.04061007,0.028543992,0.004865065,-0.036543783,0.008914114,-0.015640507,0.026007645,-0.03422164,0.026639378,-0.0331682,-0.018001646,-0.034385215,-0.0210718,-0.0034365875,0.0031890648,0.02168729,-0.027620545,0.11266937,0.2098862,-0.006483835 +4.2.3.50,"The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-alpha-santalene (EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (see EC 4.2.3.53) as well as (-)-endo-alpha-bergamotene (see EC 4.2.3.54). Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation [1]. ",384,1.0,0.016727379,-0.06684629,-0.10330057,0.04223935,0.0036045555,0.09387627,-0.029655455,0.053080454,0.0692672,-0.014928234,-0.0024836753,-0.033395417,-0.07347552,-0.028388178,0.013105284,0.01654712,-0.043536637,0.05130936,-0.014609379,0.06747305,0.032854583,-0.09655334,-0.021988915,-0.0075407433,0.05091542,0.015643816,-0.013304938,-0.015974171,-0.011673746,-0.11975907,0.030295689,0.016716111,0.049484164,-0.06698361,0.019838484,0.024165016,-0.028329141,-0.06619005,-0.005945173,0.018176798,0.08570212,0.03551933,-0.01971885,-0.06297462,-0.0206194,-0.052140538,-0.031865604,0.06797785,-0.0068877763,-0.031605322,0.032960624,-0.11777628,-0.08759086,0.012448975,-0.01696095,-0.013569199,-0.019166782,0.018305534,-0.015580517,0.09161904,0.06879376,0.008793454,-0.030502615,-0.0013106073,-0.04049563,0.007471114,0.00019405494,-0.0685125,0.03614041,-0.014556981,-0.13242297,-0.057656,-0.03804861,0.036141045,-0.002509417,0.005145928,0.039727807,0.012077101,0.025268735,-0.03818496,0.0014847819,-0.012672462,-0.012954943,0.00618614,0.03766468,0.100264706,-0.0119609935,-0.0044761505,0.074060395,0.06319749,0.08800334,-0.0027960683,-0.031340443,-0.077837646,-0.0007998385,0.022991523,0.03530732,0.054609124,0.051602803,-0.029909553,0.07744308,0.046981145,-0.042308558,-0.11828981,0.0334968,0.07546804,-0.03217019,0.017377293,-0.037110977,-0.02989287,-0.01957262,-0.035419617,0.08631957,0.002724101,-0.04729697,0.09449555,0.0044139144,-0.030090824,0.03304273,0.03890366,-0.007997723,0.046545897,0.007855672,0.07769349,-0.0096706925,0.059118282,-0.038396712,2.846422e-33,0.021712054,0.082585625,0.046148427,0.053118117,-0.01825045,-0.0010187522,-0.097195715,0.061774153,-0.07927743,-0.001141054,-0.056899615,0.004456527,0.049269035,-0.017810171,0.057580207,0.00039279053,-0.008312482,0.029393068,0.07123754,-0.038099688,-0.031005854,0.021482525,-0.060676053,0.0066117602,0.027790114,0.025625458,0.0020743485,0.016062643,0.010682103,-0.061228987,0.009729687,-0.013934212,-0.048654277,0.055933356,0.02620427,0.0015980249,-0.037872683,-0.029116139,-0.07414971,-0.021103937,0.12720867,0.03659855,-0.093552046,0.082279764,0.046427224,-0.101699896,-0.02162456,0.03784029,0.15612732,0.013126702,0.0044781175,-0.004026207,0.041642763,0.044312883,-0.11133052,0.04433869,-0.03359415,0.049735464,0.070970654,0.057626944,0.009717023,0.059448995,0.025703395,-0.0389595,0.030893164,0.05334049,-0.05424246,0.010345887,-0.06848323,0.019237455,-0.029023716,-0.052231085,0.12419991,0.019741604,0.081183,0.02644172,-0.06542637,-0.03177505,0.043684106,-0.028722823,0.013702627,0.041848876,0.031318467,-0.025310187,-0.08140037,-0.03592845,0.029519029,-0.015485394,-0.02034793,0.09530806,0.08756259,-0.07248573,-0.10995459,0.056363948,-0.019735204,-3.1043245e-33,0.07412988,-0.09295801,-0.0062332796,-0.08170561,-0.017888095,0.0033250563,0.079601735,-0.10558872,0.021775378,-0.020545734,0.09453295,-0.031121725,0.109579146,-0.0365074,3.8631915e-05,-0.04510966,0.05054212,0.05813962,0.024415012,-0.008784078,0.009006298,0.04400993,0.029318467,0.058505464,0.027805923,0.0024695399,0.068863295,-0.0027114602,0.037272155,0.056936163,0.09654904,-0.045523982,-0.0041032066,-0.03642117,-0.08884472,0.049670395,-0.08342616,0.04932243,0.040464107,0.042203154,-0.076878496,-0.05133197,-0.057171762,0.034283515,0.15849276,0.010373987,-0.074968725,0.016954558,-0.019797439,0.009185613,0.028314529,-0.03454698,-0.085258886,0.07840417,-0.018786168,-0.0025887734,-0.011044034,-0.06714078,-0.011786326,-0.047582727,-0.038700394,-0.008693004,0.028743593,-0.10376235,0.014808054,0.0075350646,-0.021280069,0.01190457,0.029994275,-0.027045716,0.070603594,0.04865765,-0.008282668,0.024996305,-0.020888623,0.0072769,0.037099045,-0.085249215,-0.0044284756,-0.07053479,-0.14270915,0.04466486,0.035065506,0.02944351,-0.049832158,-0.06971654,0.031803057,0.0777943,0.015102202,0.090523355,0.016365739,-0.027352937,-0.020906469,0.07208133,0.094313,-5.0568886e-08,0.06543228,-0.04498972,0.012723344,0.009028623,0.002875761,-0.018175153,0.0040447516,-0.04244684,-0.044909697,-0.044561904,-0.028398406,0.057454206,0.03635426,0.015237902,0.058112025,0.031434104,-0.010536333,-0.020343982,-0.01496895,-0.04112245,-0.011147238,-0.03468667,-0.04395897,-0.03460843,0.053871863,-0.08390864,-0.0338841,0.039632607,-0.039278332,-0.008782745,0.07085507,-0.022578642,-0.021896766,-0.0009214706,0.013224794,0.05239401,-0.013249194,-0.020801898,-0.03641057,0.06916425,-0.004229471,-0.13397163,-0.047374953,0.035442874,-0.023535106,0.010951288,-0.00577043,0.013416348,0.01060714,0.01936472,0.070705995,-0.064484924,-0.052787602,-0.06304613,-0.050822023,0.003011861,-0.0372815,-0.024229515,0.019514963,0.01044156,-0.0572601,-0.039044395,0.10664928,-0.035547808 +4.2.3.51,The enzyme from Solanum lycopersicum has very poor affinity with geranyl diphosphate as substrate. Catalyses the formation of the acyclic myrcene and ocimene as major products in addition to beta-phellandrene [1]. ,384,0.99999994,-0.033503454,-0.045704704,-0.100358985,0.021205002,0.08809846,0.0008912153,-0.019512882,0.06506743,0.019026484,-0.04508117,0.061425395,-0.044823207,0.0197615,0.022588022,-0.028768225,0.049469102,-0.071817696,0.04243125,-0.019012854,-0.06093119,0.007896131,0.044885416,-0.010569994,-0.009352265,0.054784164,-0.05894564,-0.004305039,-0.027886076,-0.04640304,-0.058927648,-0.0068917205,0.049630545,-0.0030279127,-0.01131908,-0.022428516,0.02241038,-0.07777953,-0.050911352,0.0720209,0.00898706,0.08243,-0.03847573,0.003338224,0.009157175,-0.033843808,-0.011164457,-0.01563112,0.018914305,0.022148242,0.05004939,-0.09095905,-0.0006181516,-0.0014365315,-0.030409273,-0.06354856,0.02020997,-0.04597787,0.014402462,0.05452473,0.08272273,0.041240484,0.0005647687,-0.02908697,-0.0019984185,-0.057768106,-0.052658077,-0.033278584,-0.034006674,0.043143198,-0.02842647,0.004971277,-0.12109365,-0.059570737,0.045782153,0.045333028,0.05145424,0.003499321,0.015997285,-0.018046334,-0.004846922,0.043809235,0.02663294,-0.015149443,0.02247514,0.047582727,-0.009087896,0.050456174,0.043813538,0.101933174,0.062403817,0.055924647,-0.03427944,-0.06969381,-0.05421937,-0.020285647,0.056287907,0.08741402,-0.0555675,-0.08771681,-0.0031576608,-0.0045772423,-0.024109123,-0.032483477,-0.014127073,-0.061950628,0.010734152,0.04206921,0.014543629,-0.034857582,0.062010296,0.0635273,0.014009145,-0.020148203,-0.105170466,-0.009376829,0.12558782,0.0015623805,-0.017427294,-0.090683535,-0.03118788,-0.010329334,-0.004833136,-0.013266351,0.049869623,-0.07605,-0.0031625447,-0.066430405,4.9120603e-33,0.020857578,0.082748525,-0.026465317,-0.0619943,0.0073806685,-0.077565,-0.0834509,0.10705812,-0.03921778,-0.08535649,-0.053331543,-0.044144243,-0.020915598,0.048316773,-0.070217185,0.0022478784,0.061714645,-0.032540236,0.078625865,-0.0019755168,-0.03929248,-0.036381185,-0.050967813,0.053723235,0.0053851106,0.017589668,-0.03178006,-0.009683245,0.07497139,-0.03965996,0.06582607,-0.09593906,-0.02277428,0.0031916942,0.045981165,0.008455897,-0.10772981,-0.08657066,0.021409253,-0.012916748,-0.038498666,0.05615455,0.043931894,0.045539573,0.06801293,-0.003522002,-0.060195968,0.062119536,-0.044498727,0.040432137,0.0455897,0.037278313,0.09180884,0.038901344,-0.04899985,0.036096744,-0.07894986,-0.013144643,0.019724088,0.021940148,-0.023845125,0.017128838,-0.007209573,0.032660358,-0.050605074,0.06718125,-0.07064354,-0.02119622,0.022832261,0.040963855,-0.033185918,-0.06490139,-0.0029882572,0.010621129,0.07737583,0.01278691,-0.0065748557,-0.026844973,-0.018462256,-0.021521417,0.019967204,0.015180899,0.033933517,0.009819355,-0.0004930078,-0.045085452,-0.066231556,-0.0014648107,0.07117105,-0.019442355,0.019739147,-0.0020090563,0.0019242918,0.059648927,-0.014125221,-4.936673e-33,0.07934978,-0.11603624,0.09818807,-0.051476523,-0.027330117,-0.01970515,-0.05934031,-0.08420704,-0.033185106,0.011834884,-0.0130941,-0.0048000743,0.01924021,-0.080912106,-0.053416457,0.037552975,0.055314753,0.17358789,0.046722967,0.044919267,-0.07029246,0.12835902,0.028839644,-0.0831329,0.015706707,-0.025347423,0.045537733,0.0231009,0.037577007,0.09147526,-0.016216751,0.0008476059,-0.033216797,-0.095793284,0.012958496,0.07331206,-0.02830148,-0.050444875,0.038633715,0.08760285,-0.031935334,0.046230897,-0.009370574,0.02730367,0.064430386,0.017338045,-0.051405825,0.045445595,-0.060360294,-0.09138553,0.020536806,0.026940135,0.015882766,-0.042849094,0.03385241,0.041691482,0.08486732,-0.0033929066,0.036280796,-0.08682152,0.006367918,-0.08654732,-0.057426877,-0.010890233,0.048330907,0.07271148,0.029471623,0.09325247,-0.0066202786,-0.013456487,0.04805677,-0.006479104,0.04566651,0.075450316,-0.010594478,0.04133417,0.03559452,-0.038168184,0.0062668156,-0.021677576,-0.026454758,-0.019177021,-0.005260447,-0.10562073,-0.022668824,-0.04068986,0.055928573,0.080498725,-0.05130565,0.07084587,0.0016744622,0.046760663,0.0065853517,0.09936673,0.16635256,-3.7698918e-08,0.08756712,-0.021699628,0.033810448,-0.021729747,0.020627193,0.008057321,0.010101798,-0.027040105,0.013083253,0.018574322,-0.101775855,0.024798663,0.0130093135,-0.03605773,0.10072623,-0.004358349,0.014297571,0.034160085,-0.05917245,0.02589076,0.035040855,0.045519553,-0.07451336,0.023624346,-0.03278815,-0.06756551,0.04310488,0.0054794974,-0.06083275,-0.0016925706,0.034190226,0.03270522,0.02258415,-0.06654892,-0.065524966,-0.0157198,-0.02932322,-0.09522312,0.03650802,-0.041520867,-0.05091243,-0.0116558755,-0.04403854,0.029059121,-0.07592578,0.013396346,0.065890975,-0.00011226879,0.025485491,0.038602676,0.061872147,-0.046557482,0.04869601,-0.09916572,-0.019786827,-0.011666977,0.00797729,0.026834114,-0.032293238,-0.11962841,-0.047366865,0.035945464,0.13497154,-0.09494975 +4.2.3.52,"Requires Mn2+. Mg2+ is not effective [1]. Some (-)-alpha-phellandrene is also formed [3]. The reaction involves a 1,3-hydride shift [4]. ",384,0.99999994,-0.04056143,-0.047926288,-0.011507698,-0.004458928,0.065631285,-0.025194738,-0.015032172,-0.020864842,-0.047384176,0.02672025,0.079908095,-0.038587883,0.029122088,0.032998603,0.036136005,0.04339048,-0.07879179,0.016961165,0.011536816,0.054165553,0.032393724,-0.031164998,0.036569856,-0.0026146711,0.023302693,0.10065691,0.10352396,-0.01210031,-0.0020669221,0.0029168283,0.015763674,0.07665254,0.04542641,-0.09192322,0.011097419,0.08178175,-0.09899203,0.0016264284,-0.008489135,0.016024401,-0.015805107,0.0005423022,0.17513818,-0.08378873,-0.04806537,-0.044922616,0.04450115,-0.018103257,0.049034417,0.069766104,0.0028078973,0.022620203,-0.009704171,-0.0017453368,-0.039901353,0.016969431,-0.16908394,0.05888001,0.03903023,-0.047986746,0.0029009616,0.018691294,-0.057297725,-0.036922984,0.00023497012,0.035166577,-0.027054168,-0.10060793,0.00983866,0.039632827,0.06281454,-0.016989227,-0.02797015,-0.0539392,-0.0027688195,0.04941255,0.121744834,-0.061227243,0.06052327,0.012920147,-0.025628878,0.021941222,0.086977065,0.045088608,0.02764849,0.06527777,0.0051513803,0.0129062915,-0.003130011,0.0433152,0.06185265,0.059372295,-0.004079213,0.03383658,-0.01578753,0.046416048,-0.044113852,0.049957838,0.013884465,0.034202747,-0.009650064,0.07613902,-0.1459415,-0.0314284,-0.03184608,0.017193932,0.03992665,0.022355897,-0.0741569,0.11129576,0.08938074,-0.0125549985,0.003888804,0.0067135626,-0.00193873,0.065320075,0.028203174,-0.060576968,-0.11230534,-0.073244564,0.058568906,-0.0052074958,-0.029406305,0.04824665,-0.080930196,0.011343517,-0.053176984,8.021337e-34,0.024529202,0.03180015,0.0163993,-0.017351428,-0.025243647,0.011589052,-0.064660646,-0.05002941,0.005813383,-0.07780399,-0.060278073,-0.043503113,0.007713435,0.010568315,-0.0723838,-0.10406143,0.07505646,-0.045816492,0.09411875,0.04405128,0.043874815,0.07592066,-0.013357566,-0.0016741788,-0.029013388,0.052272473,0.03461833,-0.030193776,0.09181696,0.0073782364,0.036152683,-0.10516483,-0.069218986,-0.02056259,-0.030319482,0.015607893,-0.14101803,-0.030044757,-0.016878158,-0.025036504,-0.11061546,0.03873488,-0.11094527,0.06401077,0.07591068,-0.059909858,0.035903934,0.03826322,-0.027974669,0.054055065,0.0032214173,0.057175983,0.019579772,0.010083271,-0.09792051,-0.025842676,0.012637003,0.036151584,0.043139488,0.061629638,-0.0058937436,0.048717417,0.070301406,0.07796985,0.027217222,0.050017808,-0.040302627,-0.08340199,-0.048918344,-0.007437127,0.0307476,-0.11597734,0.0688409,-0.0028728615,0.011206524,-0.019604908,-0.011279288,-0.020612817,0.02956822,-0.040758226,-0.008207067,0.010822094,0.053927273,0.03595338,-0.042202916,-0.031627946,-0.06529712,-0.038632955,-0.004241542,0.057113636,0.044622567,-0.023725072,-0.022523483,0.06683736,-0.015745722,-1.7848912e-33,0.00014100755,-0.009370991,0.0047939047,-0.08243403,-0.1449829,0.056666408,0.042961963,-0.087036885,0.008638522,0.015223755,0.09813702,-0.014998896,-0.10928349,-0.06885133,-0.021882853,-0.0397972,0.10054658,0.060344715,0.012506935,0.031307075,0.027488902,0.1007837,-0.03945829,0.058472127,0.025392303,0.01756275,0.06878401,0.01434854,0.034039587,0.046998188,-0.03363915,0.019999817,-0.024056397,-0.06742275,-0.009970033,0.056579832,-0.029036675,-0.027578283,-0.008334618,0.012619525,-0.02109742,-0.024296094,0.04484755,0.091537595,0.024348095,-0.014064683,-0.042471554,0.061839983,-0.023843016,-0.008516623,-0.059029136,-0.004853591,-0.034003694,-0.052491777,0.048081018,0.01267249,-0.000118712196,-0.003116661,0.060365975,-0.05544791,-0.035619963,-0.072227046,0.040389664,-0.09091024,0.04115424,0.04395355,-0.010028221,0.020335903,0.06955347,0.02118922,0.052401766,0.07007746,0.09766595,0.015030633,0.02625836,-0.025289696,0.021896845,-0.06105744,0.06511589,-0.04127286,-0.0037808432,-0.0051716403,0.028270392,-0.013285441,0.035219565,-0.09462353,0.07220984,0.08827286,-0.06034029,0.03613873,0.033832088,-0.06921515,0.027597276,0.044064663,0.05664586,-3.624338e-08,-0.018576935,-0.07235771,0.015167414,-0.07708412,-0.011462047,0.057987697,-0.011747513,-0.0684067,0.041435625,-0.062455397,-0.011427338,0.0016678397,0.03775386,-0.013313067,0.01423057,-0.032234587,-0.028945673,0.010201151,-0.07261222,-0.05541645,-0.064154774,-0.046628334,-0.095402524,0.008315031,-0.008897507,-0.031686913,0.007023941,-0.001713803,-0.09472302,-0.016225269,0.0039821533,-0.02243094,-0.015456979,-0.02192686,0.010254733,0.061675977,0.0034383575,0.016162058,0.00991281,-0.07794764,-0.12219707,0.004879691,0.04202162,0.03306687,-0.02768679,-0.0040534697,-0.039529685,0.02298856,-0.023756726,0.0036325506,0.040296324,-0.07387029,-0.008869956,-0.074900806,-0.010483672,-0.02065304,-0.007320682,-0.044359364,-0.016664153,-0.054739393,0.025634253,-0.01702441,-0.00082536385,-0.032878682 +4.2.3.53,"The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-alpha-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (-)-endo-alpha-bergamotene (see EC 4.2.3.54), as well as (+)-endo-beta-bergamotene. Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation [1].",384,1.0,0.005904799,-0.062271673,-0.10302487,0.041542243,0.0121181635,0.08520053,-0.031389616,0.052168887,0.06386594,-0.00945536,0.0035229197,-0.03677493,-0.07865641,-0.038692616,0.008811762,0.021791523,-0.041954137,0.05040524,-0.020629367,0.067929,0.040227085,-0.086303495,-0.029021217,-0.011955805,0.058064543,0.015710441,-0.012847118,-0.014737356,-0.0027880429,-0.10892858,0.03020326,0.022179564,0.045491572,-0.060315527,0.027490856,0.034765594,-0.029928666,-0.06936581,-0.0021576171,0.0301261,0.08379513,0.04305226,-0.0045409505,-0.07225395,-0.021386942,-0.04971162,-0.04053878,0.07355489,-0.00077337935,-0.029483479,0.02901397,-0.124216944,-0.09527394,0.0080757,-0.016401157,-0.02639495,-0.015282797,0.011262173,-0.019218843,0.09423092,0.06351502,-0.0004777751,-0.03495836,-0.003404402,-0.030581277,0.0058185123,0.0070634517,-0.07903906,0.027158277,-0.012771204,-0.12853806,-0.05129461,-0.053422734,0.0383777,0.003919688,0.01164503,0.04092157,0.0038346266,0.026632793,-0.038760696,0.00012412854,-4.261842e-05,-0.0064184726,0.003111976,0.03581925,0.0958934,-0.021137964,0.0027838605,0.088495374,0.068680555,0.090043895,0.00047833545,-0.035988037,-0.08193971,-0.00041252995,0.01617998,0.044033125,0.059787903,0.052065235,-0.025639288,0.06717719,0.043555357,-0.04296136,-0.11957606,0.019326542,0.07509895,-0.027877685,0.015426227,-0.038498797,-0.022742935,-0.022205994,-0.029052328,0.08266758,0.004606126,-0.04929561,0.09275196,0.0040245405,-0.040251803,0.03338213,0.03881678,-0.008128345,0.042112395,0.008996515,0.082652085,-0.016341785,0.05431603,-0.029965866,3.3669754e-33,0.01904013,0.07526996,0.048358355,0.048788376,-0.020753529,0.009054112,-0.09435502,0.051227238,-0.07867251,0.00448158,-0.0579937,-0.0037383463,0.047222156,-0.021547075,0.052063085,-0.0077017373,0.0017760755,0.03554097,0.06586632,-0.037968133,-0.023090161,0.017466787,-0.06303234,0.0022775852,0.027737375,0.025417319,0.0055065094,0.017394397,0.004546745,-0.060679752,0.002862645,-0.014263199,-0.04762711,0.05402734,0.01565886,0.0051941094,-0.040009663,-0.02725273,-0.06699174,-0.021363515,0.13061486,0.03228513,-0.09508244,0.08076561,0.05732579,-0.09469246,-0.024786307,0.030080523,0.14905171,0.0027341454,0.002313869,0.010921756,0.044206318,0.042280633,-0.10715689,0.04429498,-0.03151517,0.046166573,0.072606236,0.056672443,0.008381586,0.061220635,0.028956544,-0.029242642,0.03293367,0.047466006,-0.049582906,-0.0031131944,-0.057486825,0.019097118,-0.02363185,-0.06552627,0.12537973,0.02750587,0.07200955,0.029300598,-0.059459846,-0.02939199,0.047150504,-0.03635077,0.014838447,0.045662526,0.026712617,-0.026758794,-0.091757886,-0.040674813,0.03774913,-0.023324477,-0.03257401,0.08103169,0.09190895,-0.07866568,-0.110813275,0.05284757,-0.016845247,-3.4608225e-33,0.07685455,-0.095108606,-0.0060337954,-0.08943378,-0.026986651,0.006278642,0.07838852,-0.11035389,0.022290917,-0.015870528,0.10123852,-0.032496456,0.09986542,-0.039416883,-0.0073368517,-0.049772307,0.052272122,0.06947239,0.017370142,-0.004358253,0.009664578,0.0441253,0.036654647,0.05696725,0.01505722,-0.00030239474,0.0597113,0.00865587,0.04250347,0.064550646,0.086634375,-0.039704945,-0.009907732,-0.04155533,-0.08594364,0.05274387,-0.07570486,0.045615017,0.05081772,0.0475055,-0.07197716,-0.046908356,-0.06714275,0.03396882,0.15587431,0.01399114,-0.06602248,-0.0049104416,-0.018005392,-0.0037499506,0.024159405,-0.026507275,-0.07647455,0.07734514,-0.020525847,0.002081742,-0.010454746,-0.06749924,-0.009739259,-0.05755797,-0.041183084,0.001510305,0.036039133,-0.10634851,0.02239538,0.014359838,-0.022306794,0.003668887,0.03769001,-0.02561977,0.059716865,0.053762328,-0.0035280671,0.030069953,-0.017401228,0.0038053833,0.03768961,-0.08396129,-0.013238752,-0.07575893,-0.1488873,0.03992878,0.028323619,0.02729797,-0.04484315,-0.07976925,0.042645343,0.08244759,0.010198963,0.093678795,0.0046162102,-0.029830912,-0.013024745,0.08265511,0.102959,-5.0184973e-08,0.061510913,-0.04200081,0.022460705,0.009669707,0.0013449978,-0.0072669177,0.003589267,-0.040722296,-0.03754154,-0.04563157,-0.038509287,0.0576533,0.031159025,0.016140066,0.062508084,0.029004857,-0.022172634,-0.031536136,-0.01383635,-0.04780002,-0.007747432,-0.027005773,-0.03870545,-0.039781194,0.049765363,-0.08682365,-0.032856297,0.040642466,-0.045252986,-0.005562787,0.061990034,-0.021261927,-0.016405113,0.0006662069,0.010956788,0.06022831,-0.003894371,-0.021263322,-0.029005757,0.07355237,-0.012848767,-0.13109845,-0.06641971,0.032847546,-0.01771013,0.013122332,-0.011895887,0.017785074,0.014137622,0.017404513,0.07281206,-0.0587746,-0.05593867,-0.0658102,-0.035038766,0.0031732416,-0.041392647,-0.015868558,0.021156823,0.013546994,-0.052718062,-0.029934576,0.10086583,-0.036430687 +4.2.3.54,"The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-alpha-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (EC 4.2.3.53) as well as (-)-endo-alpha-bergamotene. Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation [1].",384,1.0,0.0070105046,-0.07055622,-0.095474236,0.03796013,0.014388479,0.08694565,-0.027080031,0.05020187,0.06832908,-0.0074304086,0.0019249745,-0.039049607,-0.0779179,-0.043222092,0.013792892,0.022515796,-0.04153862,0.049734615,-0.018505499,0.07370325,0.042014126,-0.09219013,-0.030468907,-0.01736871,0.059003647,0.016617076,-0.012559117,-0.019373875,-0.005247354,-0.10796833,0.026222682,0.025001505,0.048322886,-0.06284578,0.026760016,0.031867847,-0.026930403,-0.06836062,0.00012870491,0.02329507,0.077708334,0.040793028,0.00076786295,-0.07312568,-0.02425748,-0.048754666,-0.035304863,0.072672516,0.00011151393,-0.027501453,0.027542483,-0.122341536,-0.09399112,0.010009216,-0.016249945,-0.020786837,-0.018870478,0.011545037,-0.018484347,0.09698771,0.061628025,-0.0039348933,-0.035549443,-0.0013845962,-0.027636843,0.0071780486,0.006405155,-0.07636066,0.03356054,-0.013652852,-0.12957498,-0.042220585,-0.045692038,0.032709405,0.0050601964,0.013011266,0.04282177,0.0026857397,0.030909471,-0.049616303,-0.001470638,-0.0025612323,-0.0051750857,0.002629913,0.035864275,0.09392215,-0.020258436,0.004141788,0.08469832,0.06681936,0.08701422,-0.0010990526,-0.03590361,-0.08096635,-0.0017170815,0.018161418,0.037962403,0.06336832,0.05714623,-0.023257552,0.07148342,0.046201643,-0.040768165,-0.11732434,0.024849733,0.06998399,-0.032289658,0.02181427,-0.04329674,-0.027982576,-0.022092909,-0.02453906,0.088098116,0.010684634,-0.053125117,0.092213616,0.0062388186,-0.044260528,0.031988442,0.036932357,-0.012381436,0.04903725,0.011416573,0.0797574,-0.017779522,0.051109556,-0.026632119,3.258741e-33,0.01640174,0.07272952,0.056198474,0.05093965,-0.019725274,0.006912108,-0.09732764,0.049427062,-0.07598019,0.009659202,-0.058431786,-0.003656387,0.05207222,-0.020326532,0.05451867,-0.007791387,0.002301716,0.034570888,0.06817583,-0.040307213,-0.02665902,0.02101593,-0.062201716,0.00039544422,0.029888544,0.031758387,0.003787639,0.021840703,0.0050033685,-0.06052941,0.004409053,-0.016302753,-0.046324577,0.054480173,0.015311613,0.0051954896,-0.04305806,-0.025125396,-0.06865748,-0.022977535,0.13338308,0.029606892,-0.10348879,0.08153419,0.05323111,-0.0966421,-0.026624698,0.03028071,0.14520758,0.0018827657,0.004116661,0.009175461,0.046327136,0.04641584,-0.10781628,0.038129505,-0.03175272,0.042219,0.0720195,0.05506086,0.011570132,0.0620088,0.032748066,-0.026649483,0.031414974,0.043612663,-0.05329886,-0.0027025014,-0.057080746,0.026346,-0.021334125,-0.06534546,0.12203505,0.029489607,0.07161363,0.031315465,-0.06300914,-0.030704122,0.04335221,-0.026015135,0.014790201,0.041361623,0.028015757,-0.02746274,-0.101560734,-0.037240077,0.032067493,-0.029035617,-0.025313219,0.08646071,0.08857405,-0.07813712,-0.11553366,0.046742577,-0.017096562,-3.4873828e-33,0.07403366,-0.090788804,-0.003127178,-0.08854542,-0.027265538,0.008370077,0.08287138,-0.108716525,0.018190876,-0.017416831,0.09597093,-0.025504852,0.10152859,-0.04467578,-0.00825013,-0.048261687,0.050219487,0.07159295,0.024954433,-0.00018630795,0.0067070327,0.043643553,0.035441887,0.06033292,0.014147569,0.006412248,0.0637709,-0.0008498817,0.042485196,0.06271881,0.08459874,-0.041024663,-0.0074236114,-0.03953745,-0.07962448,0.049621407,-0.079134084,0.03965561,0.045860026,0.0433894,-0.07943083,-0.041619305,-0.0632804,0.032539494,0.15469961,0.008917767,-0.06425577,-0.005588333,-0.026871283,-0.0021861705,0.026128631,-0.028774884,-0.08030188,0.07367628,-0.017963223,0.00067983725,-0.016061947,-0.0716629,-0.008739449,-0.052454203,-0.043225847,-0.0039928975,0.028988678,-0.10679825,0.027204422,0.014856852,-0.02184728,0.005739861,0.034164984,-0.022922922,0.060799673,0.059705,-0.0054897247,0.028638344,-0.013700625,0.0055562505,0.038747482,-0.08353626,-0.011949275,-0.07677151,-0.14593591,0.03702741,0.029152308,0.027349833,-0.046386737,-0.07955701,0.040118255,0.07973241,0.0074074585,0.09392146,0.0027086805,-0.036863662,-0.0224201,0.08186542,0.104890354,-5.0349193e-08,0.061935075,-0.040542115,0.022403292,0.011378917,-0.0057624984,-0.008788919,0.0034783545,-0.03346343,-0.045331713,-0.044599853,-0.039970145,0.05424904,0.033127535,0.0120569,0.0625181,0.027419373,-0.022991527,-0.02973878,-0.01826746,-0.047583498,-0.0065929205,-0.023548508,-0.036273915,-0.038259868,0.04950155,-0.08675361,-0.034669705,0.040640652,-0.04639855,-0.005730733,0.06761755,-0.023478376,-0.019380596,-0.0013021185,0.016978612,0.057895776,-0.010963677,-0.026422434,-0.029559067,0.076329105,-0.015895754,-0.12451989,-0.06477951,0.034583714,-0.02135331,0.010527895,-0.012381484,0.021584643,0.013365863,0.023180494,0.069713496,-0.05256527,-0.056138773,-0.067206234,-0.040096685,0.0070557557,-0.038359385,-0.020264665,0.019549573,0.017741654,-0.05074094,-0.03164134,0.10095803,-0.04172355 +6.1.2.1,"The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.",384,1.0,-0.0137462765,-0.055959772,-0.088520594,-0.060124546,0.027029911,0.0022888207,-0.05186804,0.10016459,0.054584514,0.0092175165,0.022219403,0.022960333,0.00365642,0.08597786,-0.03963866,-0.037454925,-0.045058753,0.0026262535,0.021082468,0.007380363,0.022490239,0.04383648,-0.022617139,0.014424444,0.032645002,0.040270217,0.06135775,0.03237985,0.01565972,-0.06456399,0.021088148,-0.09572044,-0.01218188,-0.033423286,0.061223343,0.0211965,-0.029989721,0.014257683,0.06679161,0.038318373,0.042422783,0.030365232,-0.00577518,-0.030059973,0.033787664,-0.015237827,-0.048299436,0.10462289,0.039376408,0.024631944,-0.016949065,-0.06323213,0.03062105,0.020206043,0.041863944,0.035500314,-0.08751946,-0.0309203,-0.0080699865,-0.010844028,0.06310931,0.05097796,0.08132386,0.008238889,-0.06666619,-0.068164006,0.015265432,-0.044927437,0.07019361,0.059001002,-0.104773365,-0.04899825,-0.00022037407,0.003227892,0.069608204,0.010629316,-0.0082859965,-0.051922444,0.03411168,-0.069353335,0.052980915,-0.01938754,-0.0034808351,0.10660228,0.0013438857,-0.04215109,0.0777228,-0.04888798,0.06533334,-0.00691847,0.036522128,-0.07038447,0.010527158,-0.073007725,-0.10416098,-0.0549669,-0.03936765,-0.015011744,-0.06479012,-0.035116836,-0.055311464,0.011504104,-0.08134961,-0.048266247,-0.058066238,-0.0038021186,-0.01455962,0.0097218575,0.067568526,-0.018089226,0.013646465,0.042519692,0.025162209,0.025255103,-0.04174334,0.072603725,0.016858276,-0.07836717,0.04214851,-0.021053607,0.031784635,0.022831565,0.04547087,0.078599095,0.03862138,0.07612259,-0.039536376,1.6689882e-33,0.0591483,0.011687534,0.032232996,-0.024525665,0.007883848,-0.024009796,-0.082478285,0.02945989,-0.0374608,-0.05952588,-0.07856136,-0.061143022,0.050438732,0.09364105,-0.020833414,0.07248859,-0.003581078,0.0438281,0.026046125,0.05481398,0.0057108747,0.06745497,-0.014662267,0.0018778439,0.10303744,0.067188166,0.0072275116,0.04658287,0.1299442,-0.00024233869,-0.053592023,-0.07378975,-0.058300395,0.03259513,0.037243858,0.011290637,-0.038697533,-0.052558333,0.07428729,0.059041258,0.040598996,-0.0030693978,-0.0019879094,-0.055534687,0.029424883,0.022334537,-0.011216161,0.074075684,0.0046195667,0.035336044,0.101739086,-0.031833395,0.048345245,-0.037464846,-0.08190874,-1.7082035e-05,-0.068124965,0.017288283,0.07039279,0.060832083,0.015158287,0.031295836,-7.74659e-05,-0.024507862,0.026967762,0.031123776,0.0019361533,-0.04622973,-0.0044389335,0.00057134364,-0.11265152,-0.025731014,0.07891842,0.039800555,0.007196904,-0.037344642,-0.03787033,0.041822236,0.05748992,0.00013600706,-0.083992936,0.019045208,-0.01630246,-0.060931467,-0.027733821,-0.027182294,-0.0326888,-0.070030145,0.022969518,0.05350364,-0.065370865,-0.021962522,-0.07626163,0.056705598,0.010983231,-2.9880703e-33,0.031227387,-0.1256686,0.036298413,0.022415023,-0.09961757,0.06503342,-0.03552824,0.008036944,0.09704636,-0.0678706,0.07892541,-0.04003588,0.01101153,-0.049164202,-0.01187834,-0.0017811272,-0.05939664,0.074327104,-0.03191071,-0.040845316,-0.010943488,0.00049842516,0.025443306,0.0041618543,0.035493515,0.03340984,0.027430154,0.02582143,0.041231737,-0.023427036,0.006793561,0.028035212,-0.073799945,-0.033410177,-0.14705996,0.11042026,-0.068379864,-0.04907966,-0.008603594,0.0035070227,0.0113616595,0.021747708,-0.010199232,0.06049222,-0.0056130136,0.045106776,0.012798936,-0.011201447,0.051567536,-0.0041046487,0.040346276,-0.059465706,0.03524995,0.061360847,0.012832837,0.066677205,0.07558265,0.034949478,0.018081227,0.0169804,-0.0338467,-0.0498629,-0.012190424,-0.020478949,0.047463015,0.015918119,-0.0032326193,0.07243905,0.12363164,-0.06253001,0.08088334,0.045393396,0.05615801,0.030210817,-0.0020128516,0.06542117,-0.043806773,-0.09362066,0.0232252,-0.08425863,-0.051069915,-0.02679482,-0.041115366,0.0037795717,-0.030937094,-0.020882832,0.0043982896,0.11678217,-0.010056614,0.078221954,-0.038075358,-0.025148194,-0.011819812,0.060731057,0.10022139,-4.349154e-08,0.09336045,-0.06433016,-0.02289341,-0.025051622,-0.014900186,0.0032044072,-0.040545348,-0.027096173,-0.0487888,-0.046098247,0.024123797,0.02408755,-0.050563607,-0.02056933,-0.028203748,0.0919961,-0.056809496,0.0019516055,-0.033583447,0.044182047,-0.12719554,-0.017878147,-0.11591943,0.0050478033,0.016203377,-0.056000903,0.037596665,0.02345437,-0.06018684,-0.019850867,0.003582648,0.022631926,-0.07838353,-0.034801424,-0.051943477,-0.044550005,-0.10276169,-0.0124868145,0.026442815,0.0075026182,0.016697997,-0.019451223,-0.09407084,-0.023524284,-0.058200285,0.02248124,-0.03682713,-0.021153608,-0.100807816,-0.00091335387,0.004626703,0.012588803,0.051654525,-0.032635625,-0.09748796,0.021387069,-0.027830048,-0.10825511,0.005676284,-0.039243102,-0.047994807,-0.019375348,0.18686822,0.027987614 +2.5.1.95,"Involved in the biosynthesis of the polysaccharide xanthan. 30-40% of the terminal mannose residues of xanthan have a 4,6-O-(1-carboxyethan-1,1-diyl) ketal group. It also acts on the 6-O-acetyl derivative of the inner mannose unit.",384,1.0,0.0791707,-0.015648978,-0.03320365,-0.083355136,-0.0050714053,0.034293253,0.050873715,-0.005858203,0.04491261,0.061316278,0.07693334,-0.05400045,-0.088068955,-0.085578196,-0.057742547,0.03199823,-0.011605463,0.021937026,-0.0756615,0.04325747,0.098897554,-0.024147166,0.05642177,0.020231597,0.058973063,-0.022304557,0.0013043982,-0.045553476,0.046119347,-0.11431853,-0.0363325,0.019493228,0.036351882,-0.06010405,0.07816882,0.05400226,0.08554568,-0.05829917,0.13162924,-0.027959635,0.06355563,-0.036664147,-0.005302816,-0.032479107,-0.024403945,-0.045740683,-0.054894067,0.034668572,-0.024243055,-0.016331838,0.033674195,-0.028124869,-0.019888848,0.013375553,0.06619515,-0.044808805,-0.023436468,-0.026480183,-0.01133562,0.018120354,0.039930385,0.100650154,0.052137014,-0.020820921,-0.032169,-0.14190635,0.050263986,-0.11437462,0.013951013,0.03109778,-0.04797431,-0.029916905,0.00721813,-0.079181306,-0.016449606,-0.009800993,0.023102503,-0.08025649,0.014548744,-0.015162134,0.020218618,0.07686065,0.10638549,0.036662605,-0.0250919,-0.05305517,-0.032819398,0.029592797,0.023232784,0.0241421,0.045897856,0.029228974,0.028878607,-0.048842993,-0.0006624475,-0.070607275,0.088272244,-0.014455448,0.07470621,0.00040429868,0.01864386,0.02233657,-0.0008651594,-0.07321645,-0.058788285,-0.015655601,-0.018148087,0.02047923,-0.013127872,0.034905966,-0.067633316,-0.05370073,-0.009882151,0.028405556,-0.13269846,0.061771125,-0.008415415,-0.06967253,0.0026163983,-0.08427612,0.035707396,-0.016172426,0.008101245,0.108211525,-0.051763847,-0.020243341,-0.057723653,-1.2075489e-33,0.05412533,0.026348682,0.058568496,-0.076441236,0.07998618,-0.037274517,0.011462513,-0.018109009,-0.04199091,0.025687682,-0.10235026,-0.11889125,-0.007968826,0.003537922,-0.043146808,0.0511042,-0.14052556,-0.043008517,0.0010224654,0.001134488,-0.055871654,0.05056194,-0.055981193,0.040918544,0.042717606,0.016994106,-0.013457416,0.00314548,-0.01926673,0.013982193,0.054508254,0.0065399054,-0.07711048,0.037026353,0.011700975,-0.0035948986,-0.028100045,-0.020842906,0.02593529,0.07791361,0.01763583,0.044916946,0.005972012,-0.07330912,0.010614951,0.020377986,0.012597602,0.04326958,0.06319018,0.03925464,0.011181764,0.00054692564,-0.0055067693,0.07336161,-0.031002177,0.02127163,-0.09575589,-0.0013402507,-0.0063382722,0.06837398,0.0023257681,-0.011153202,0.044337664,-0.042186752,-0.0056366436,0.031172642,-0.038617328,-0.008825406,-0.0002551757,0.017983407,-0.11797194,-0.08616679,0.07133255,-0.027370442,0.028917838,-0.0021952512,-0.07130918,0.035308853,-0.03259388,0.0011184904,0.11647137,0.014265888,0.004824236,-0.1049272,-0.09204283,-0.0037072937,-0.01184787,-0.024815222,-0.05007739,0.07781997,0.01736443,-0.08570791,-0.0487947,0.07417355,-0.023209212,-1.7123827e-33,0.0540504,-0.035343956,0.061078493,-0.0046885116,-0.062045317,0.005980113,0.032401424,-0.082340464,0.0047368547,0.0025571536,0.070556246,0.05299768,0.026989013,0.06399621,0.010130913,0.04586387,-0.0006776589,0.15489689,-0.03353732,0.00052623224,-0.018571947,0.04637871,-0.021195354,-0.036470912,0.06491603,0.002833426,-0.023689045,-0.015010937,0.04098074,-0.0074678953,0.01709424,-0.04494281,-0.035775255,-0.04139886,-0.06341112,-0.09292022,-0.0827052,0.04076646,0.009479084,0.10074636,-0.043406483,-0.006064648,0.0825606,0.022031222,0.06436808,0.0435545,-0.025008041,-0.0615157,0.0077402703,-0.014868888,0.03591967,-0.023627846,0.016419245,0.04339041,0.007250722,0.13146256,0.025447344,0.046135932,0.007238071,-0.027276868,-0.025905047,0.0217748,0.112703994,-0.07378489,0.041241273,-0.007674811,0.0020312548,-0.0018399386,0.11605837,-0.0272924,0.049169373,0.008957066,-0.0060662786,0.06427124,-0.037184972,-0.017314492,-0.10277531,-0.10241864,-0.037939057,-0.013476252,0.0042102444,0.004059536,0.04006436,-0.017499417,-0.030813742,0.003524233,0.08132834,0.13388813,-0.009261082,-0.006758843,0.008125592,0.026034009,-0.033169676,0.058576558,0.06363273,-3.632538e-08,0.03190774,-0.10690678,-0.037381906,-0.038642228,-0.028403817,0.018616106,0.015111849,0.016849808,0.0056038876,-0.021170346,0.024440786,0.08013914,0.02249679,0.006782415,-0.015060879,-0.045322496,-0.015355223,0.009367583,-0.034818407,-0.05724624,-0.10425551,0.009171289,-0.01240231,-0.018251097,-0.010521302,-0.0489245,0.030820195,0.042452198,-0.037901152,0.03108209,0.0008983515,0.057613168,-0.01087613,-0.048673086,-0.012950832,0.09825689,-0.073180355,-0.063305765,0.05578186,-0.034181975,0.03685787,-0.088164255,0.02440287,0.007651341,0.057168655,0.023001496,-0.0033468816,0.018803153,-0.04829961,0.0447613,0.025789691,0.014675247,-0.10730899,-0.014649229,-0.029133141,0.020895356,-0.08713047,-0.0069854795,0.035082106,-0.026088253,0.029057024,-0.0064709997,0.10488819,-0.08764725 +2.7.7.77,Catalyses the guanylation of the molybdenum cofactor. This modification occurs only in prokaryotes.,384,1.0,-0.03884397,-0.07092801,-0.12963687,-0.03915949,0.05476536,-0.018825037,-0.011970837,-0.049069222,0.016467843,-0.038690146,0.101983845,-0.010719683,-0.021236183,-0.019275466,-0.045658708,0.013733877,-0.03548779,0.043395083,0.016453104,-0.020903727,0.052185908,0.05444251,0.008374954,-0.06467831,0.00540804,0.01837223,-0.021941632,-0.015202877,0.08162847,-0.12949754,-0.02618502,0.0711181,0.009852659,-0.023955818,0.07415845,0.053185634,-0.013529685,-0.019215055,0.09756005,0.0051570735,0.03126906,0.060360778,0.07475031,-0.021601085,-0.051091854,0.03265678,0.051885113,-0.025424393,-0.027499234,-0.020320622,-0.015461956,-0.04709669,-0.09818918,0.018994786,0.014900574,0.051583942,-0.032732118,0.014265957,0.07098715,-0.026814366,-0.014834404,0.056014247,0.056369256,0.027067497,0.014385271,-0.073664255,0.006115579,-0.039105434,-0.012348553,0.017767467,0.023892803,-0.0075926483,-0.0038379496,0.01995538,-0.068572275,0.09790327,-0.008720654,-0.016272673,0.05869632,0.049272887,-0.023360513,0.08659662,0.09085729,-0.011481592,0.032975323,-0.044141226,0.029198946,-0.031889867,0.0036054153,-0.015820546,0.06916482,-0.021170333,0.003045692,0.002677728,-0.14379588,0.0046846643,0.07648203,-0.013558147,0.00092918327,-0.0334902,0.0061819064,-0.0015452481,0.006503299,-0.015422648,-0.03903096,-0.009571312,-0.009753323,0.102441974,0.013018474,0.06782503,-0.03725288,0.06523487,0.06588465,-0.07538485,-0.022828577,0.011302782,0.02990029,0.036180943,-0.037682354,-0.024120327,-0.0066665155,0.008493466,-0.042949382,-0.0090640085,-0.1393603,0.037721667,-0.07566303,2.414469e-33,0.13292702,-0.009257054,0.02813312,-0.0095778955,0.044467326,-0.018677453,-0.057310335,-0.0664703,-0.014702483,-0.063026495,-0.019839043,-0.045121223,0.03660461,-0.009427281,-0.047779895,-0.025829569,-0.07328556,-0.057644043,0.042554434,0.020199394,0.014391816,0.06864717,-0.012688333,-0.0089848675,0.004610607,0.029184693,0.06578688,-0.026104094,0.0068427473,0.021698792,-0.008199655,-0.08317593,-0.09363522,0.039818328,0.036446594,-0.033014398,0.008311723,-0.060809124,0.01328529,-0.015382989,-0.057155833,0.006379831,-0.07117423,-0.062008522,0.03823909,0.006143994,0.040873323,0.111813866,0.009578313,-0.0024689978,-0.004779396,-0.04856812,0.026012463,0.03450547,-0.08112557,0.006668412,0.01817218,-0.03915222,0.010680939,0.06097176,-0.0015246576,0.03264556,0.04181471,0.04222659,0.005547287,0.06660845,-0.12010583,-0.06981492,0.06223489,0.05244984,-0.11195263,-0.003739209,0.035556406,0.020014348,-0.044673745,-0.07040536,0.033139862,-0.07054514,0.0049973214,0.04592281,-0.01563507,0.031173436,0.027490396,-0.039876264,-0.011767144,-0.0178571,-0.10798303,-0.0012013806,-0.066234246,0.047793552,0.0800108,0.0015110808,-0.021960698,0.047411624,-0.061996184,-2.235053e-33,0.113814786,-0.10094209,0.08866523,-0.055359054,-0.11200193,0.012065965,0.004087078,-0.077190585,0.02147658,-0.017453808,-0.05478323,0.02809254,0.025493883,-0.031181006,-0.014334082,-0.032548454,0.028276248,0.08518577,0.0017115823,-0.043918736,0.016102992,0.03738995,-0.025516892,-0.08891531,0.037434045,0.047153566,-0.052484773,0.012897492,0.02530985,0.018055102,-0.013258084,-0.032524295,-0.12197881,-0.04500176,-0.0787355,-0.00633723,-0.015437924,0.024023276,0.0011256541,-0.040822867,-0.014094673,0.05195611,0.04629519,0.090786934,0.07630333,0.029148038,-0.078338474,-0.028230898,0.047483973,-0.0037542696,-0.0075876014,-0.02060374,-0.03371349,0.0053326692,-0.002792626,0.01634,0.05393618,-0.032448985,0.028560553,0.018752486,-0.030995179,-0.02844476,-0.0050652944,-0.035361435,0.057062745,0.14524242,0.032623854,0.07251333,0.103241615,-0.03627423,0.058438104,0.092388846,-0.03131012,0.010352733,0.045990784,0.025778957,-0.05312996,-0.03204123,-0.00985355,-0.010679278,-0.01931892,0.017987335,-0.022561146,-0.058578,0.03180929,-0.034695674,0.025184013,0.108151905,0.04494493,0.02189671,-0.0656139,-0.035308946,0.021916125,0.03281938,0.059572272,-2.3837352e-08,-0.089275435,-0.03187663,0.009753365,-0.04026042,0.027858552,0.13950017,0.020213474,-0.004251347,0.10084123,-0.089894444,0.039864153,0.077140756,0.054377783,0.0026311236,0.036377195,0.09389529,-0.05541549,-0.07556112,-0.0049300343,-0.011869922,-0.02765524,-0.049137123,-0.07006626,0.19193244,-0.031530738,-0.03888675,0.056857705,0.08896598,-0.09009169,0.01584835,-0.04544968,0.0021605785,-0.008338108,-0.038029913,-0.018591842,0.008500048,0.013030173,-0.029556097,0.006897685,0.027226983,-0.005019343,0.015903503,-0.038874555,0.015971186,-0.010760079,0.029689146,-0.046639528,0.022283442,-0.02354972,0.03194022,0.08384284,-0.01834298,-0.019462673,0.0030601986,-0.12609707,-0.012965622,0.027658854,-0.041890543,-0.036156576,0.035393212,-0.0042835684,0.0057445965,0.14816616,-0.04959998 +2.7.8.33,"This enzyme catalyses the synthesis of N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. The enzyme also initiates the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide in certain Escherichia coli strains, including K-12 [2] and of teichoic acid in certain Gram-positive bacteria [4].",384,0.99999994,-0.075960614,-0.04691229,-0.12877613,-0.032573346,-0.067793824,0.026343651,-0.050169315,-0.0030743573,0.07641952,-0.0020960052,0.020819236,-0.03716079,-0.071463175,0.010255559,-0.059139058,-0.020636823,0.0040245093,0.020296501,-0.033662584,-0.020154038,0.039132435,-0.018262079,-0.045474805,-0.07095648,-0.009042624,0.051486902,0.103389,-0.014421315,0.024850298,-0.052615747,-0.021911204,-0.074256584,0.10714243,-0.11186907,0.09082925,0.028361972,0.0017173408,-0.014778414,0.061602082,0.0012588107,-0.02296445,-0.010098206,0.009741172,0.0114972675,0.035705805,-0.059856422,-0.007425248,0.09173984,0.07299045,-0.035006784,-0.009970426,-0.056855753,-0.04260811,0.08254398,0.012213018,0.056805298,-0.08596351,-0.045276977,-0.013024379,0.026619075,0.0058343047,-0.0037264365,0.082053356,0.022635242,-0.07306889,-0.08479869,0.035231367,-0.03366863,0.0037079784,-0.009698046,-0.079507366,-0.029446865,0.028328018,0.04173534,-0.016054861,0.005063779,0.03613974,-0.03704913,0.061472885,-0.0106801065,0.07694825,-0.051806074,-0.07715529,0.13977006,-0.0015999513,-0.03438315,-0.032822452,0.0008890838,0.09281618,0.058030054,-0.0012472556,-0.089277804,0.027703097,-0.109145455,-0.06334582,-0.011734108,0.010535715,-0.015227532,0.019326426,-0.038160317,-0.048774976,0.014913326,-0.000108676526,-0.08891985,-0.075066164,-0.009043585,-0.019378573,0.06965112,0.0008350389,0.010619385,-0.006774284,-0.049170114,0.009109931,-0.050406855,-0.04793951,0.03816489,0.012542768,-0.10848629,-0.01803705,0.00974043,-0.033593222,-0.074163675,0.03457,0.1102115,-0.032246824,0.044640355,0.0018206597,2.6863626e-33,0.053829752,0.012979791,-0.022289557,-0.017064821,0.029585967,-0.06799039,-0.047029246,-0.084744625,-0.041579377,0.012544292,-0.068121254,-0.13209938,0.056495246,0.040595777,0.0452804,0.08316453,-0.0050898856,-0.0072135455,0.042238504,0.045514233,0.030810954,0.07770365,0.017758593,-0.012031811,0.06706612,0.114447705,-0.04594161,0.007477867,0.036674622,0.0059774974,0.034886327,-0.014751578,-0.08257324,0.031610638,0.105814986,-0.0015255511,-0.059276637,-0.0067464025,0.044810697,0.02115831,-0.0047963443,0.036230203,-0.050634902,-0.02062125,0.050810937,-0.0040531624,-0.016061997,0.034683138,0.10913904,0.012540638,0.06648443,0.010752109,0.08585881,0.0171187,-0.047062572,0.024061227,-0.031585068,-0.015541878,0.05527367,0.035269313,-0.07632408,0.051159043,-0.06794775,0.03891745,-0.03438286,-0.012859417,-0.033013448,-0.023735931,0.020566719,0.069981635,0.003972962,-0.02119712,-0.027104972,0.023024008,0.036616217,-0.026605807,-0.023368422,0.024188254,0.086363286,0.0011742177,0.07675956,0.023541696,0.013783722,-0.06283085,-0.022732083,0.058499124,-0.08044187,-0.008145459,0.025152387,0.086725235,-0.015020743,-0.044678178,-0.0918982,0.089347035,-0.00025517054,-5.730465e-33,0.057269536,-0.14791372,0.021564838,-0.08984848,-0.057317533,0.09293045,-0.055364136,0.018481389,0.074129164,0.06364309,0.047731888,0.02132608,0.028064204,0.047593087,0.0008039124,0.011570031,-0.022120954,0.06706454,-0.03901372,-0.0892635,0.025039371,-0.013186357,0.016546967,0.00061228784,0.059561122,0.014301845,-0.031345982,0.10350965,-0.017973013,0.075135335,-0.020855112,-0.058244195,-0.042631112,-0.017126534,-0.0339282,0.040864423,-0.007653374,0.037399873,0.0002231969,0.024203077,-0.031152949,0.037164073,0.060702734,0.01812194,-0.04097817,0.011454502,-0.019755889,0.04011014,-0.0003684072,-0.07560363,0.034921985,-0.01016783,0.016360467,0.055108417,0.018403042,0.051680982,0.006009612,0.044197436,0.011273912,-0.057058793,-0.043326326,-0.15394211,0.034931805,-0.032308735,0.089006275,0.08428767,0.0039361594,0.025704917,-0.0015348059,-0.050118744,-0.01323482,0.0063447007,-0.008778498,0.017541775,0.04785468,-0.03499734,-0.06444309,-0.053039346,0.035247486,-0.0064746807,-0.023819739,-0.048687167,-0.012302281,-0.0013090109,-0.005695496,-0.06397721,0.06267721,0.09282079,-0.0008360462,0.08070956,-0.019983431,0.019826274,-0.061906654,0.016420335,0.06768671,-4.1866066e-08,-0.00615051,-0.09214953,-0.008604059,-0.07165265,-0.008589073,0.031509317,-0.05036911,-0.03521662,0.07595842,-0.06293527,0.051821962,0.14697814,0.027180513,0.042089354,-0.04666561,0.018755993,-0.05878157,-0.03608609,0.007283536,0.012037634,-0.0012270093,-0.008499102,-0.05134053,-0.035248674,0.01858057,-0.07895489,-0.0051033744,-0.021108074,-0.0845268,-0.029151183,-0.05636538,0.019754576,-0.05653765,-0.08419943,-0.03422113,0.04632136,-0.026631674,-0.09134997,-0.011447539,-0.0030987028,0.037651934,0.038183637,-0.058974363,0.016926572,-0.03786303,0.0007533685,-0.039821688,0.02697405,-0.071062334,-0.008337269,-0.032002702,-0.036107495,-0.018275796,-0.044454575,-0.063347615,-0.06330407,-0.00049996056,-0.07370755,0.029497229,0.034716915,0.040301125,0.0488306,0.17126924,-0.021450328 +1.1.5.8,"The enzyme is membrane-bound. Does not use NAD(P)+ as acceptor. Contains pyrroloquinoline-quinone. cf. EC 1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+], and EC 1.1.1.25, shikimate dehydrogenase (NADP+).",384,1.0,-0.057658542,-0.0019074609,-0.03861994,-0.106195666,0.03933261,0.047472946,-0.02621954,0.046752423,0.048541337,0.01519888,0.021528594,-0.0061925002,-0.07174829,0.062034357,-0.042179782,0.012338176,-0.04559424,-0.05195934,0.03619928,-0.035395455,-0.011939729,-0.05327981,-0.011662385,-0.047168776,0.0338944,0.038720272,0.039363917,0.03293792,-0.030997835,-0.039485224,-0.078988075,0.0062379222,-0.011898646,-0.02312537,-0.04686754,0.12062495,-0.12887293,0.02110178,-0.022615336,0.025452312,0.0482968,-0.0008188121,-0.03961008,0.00926025,0.0012769278,-0.019859854,0.0007102601,0.057304427,0.029427629,-0.01971982,-0.065434,0.020612746,0.021853186,0.002023265,0.03653152,-0.034708016,0.07505307,-0.021996226,-0.10473031,-0.035644755,-0.036383882,-0.06541083,-0.0396547,0.0029166173,0.00051069143,-0.03311984,0.06625246,0.0049590254,0.0019964715,-0.027623234,-0.09514931,-0.010323041,0.007622228,-0.000412015,0.017959217,0.06387055,-0.049874283,-0.03023482,0.04414373,-0.045776438,0.024483897,-0.022751154,-0.047418762,0.058468662,0.093016416,0.019092835,-0.00012297934,-0.013884268,0.016208868,0.043997277,0.062138844,-0.028965754,-0.07515797,0.01077858,-0.083354,0.028219908,0.00440064,0.03709377,-0.030270088,-0.08904741,0.047978755,0.055520635,-0.08167222,-0.08050319,-0.08487828,0.03423443,0.0145059535,0.08134036,-0.051964864,-0.0037679186,-0.040244546,-0.029545492,0.060162865,-0.022456529,0.0026636967,0.07387137,0.063515306,-0.03221278,-0.01698979,-0.02249189,-0.04223731,0.05310954,0.076024726,0.04724782,0.0038938147,-0.0162778,-0.066074036,1.9342185e-33,0.04437658,0.039729387,-0.0140159875,0.0010303031,-0.04972003,0.061144516,-0.081638925,0.050318457,-0.14097303,-0.082316466,-0.05815741,-0.079675205,-0.0017696201,-0.014310955,-0.005608106,0.075725935,0.0048112124,-0.058071803,0.02246652,-0.015411826,0.041606706,0.04498347,-0.02960124,0.009688418,0.013143396,0.018537477,-0.010209167,0.062182672,-0.008131386,-0.03923682,0.074127786,-0.10707294,-0.07090401,0.05417462,0.013277656,0.016012108,-0.023185153,0.004938416,-0.070830226,0.03415572,-0.06100106,0.048789725,0.035472147,-0.012819186,0.020842021,-0.11542,-0.017827127,0.07856362,0.043808,0.05195409,0.032807216,0.03174941,0.0698067,-0.07959861,-0.109785445,0.007007255,0.019551553,0.040381715,0.007952577,0.070465274,0.071242325,0.05008582,-0.02569055,-0.0014888935,0.029523699,0.020451022,-0.052192613,-0.0496174,0.037008364,0.07603026,-0.021832557,-0.018612973,0.0640655,0.076821916,0.06532209,-0.04816487,-0.0047400207,-0.017936166,0.00814299,0.03598489,0.0066705514,-0.05708231,0.053820107,0.038332704,-0.06924449,-0.014507303,0.04017173,-0.046909172,0.0070088976,0.016646514,0.014480989,-0.026925674,-0.05310784,-0.004691306,0.07128168,-2.9226955e-33,0.046581436,-0.009877196,0.05697127,-0.044162586,-0.026595507,0.13709183,0.040238105,-0.07638548,0.060842454,-0.060466763,0.10467484,-0.04087862,0.027685763,-0.018877529,0.033265762,-0.029548893,-0.11881954,0.054632638,0.0044264025,0.015712066,-0.04022184,0.07929165,0.019947518,0.057739794,0.02204371,0.0037380517,-0.03908231,0.050944567,0.030221121,0.0317038,-0.010534464,0.01481204,-0.07413061,0.0075237984,-0.049195163,-0.015584123,-0.06387092,-0.014040902,-0.01026767,0.10839335,0.023989458,-0.0059578833,-0.013073159,0.02795888,0.0005572504,0.034871407,-0.071076795,0.014743581,0.049668077,-0.04768004,0.033604052,0.09483687,-0.016362213,0.053,0.15660205,0.040643133,-0.0032332013,-0.008223846,0.08490844,-0.046291795,-0.047384974,-0.058204796,0.00962106,-0.034613285,0.0052219494,0.020143181,0.009279501,0.046930954,0.043688506,-0.030623294,0.061494693,0.072474144,0.0069966274,0.040855337,-0.03669637,0.04294244,-0.020900983,0.046839118,0.02086078,0.0032582232,0.044930395,0.009741527,-0.06495229,-0.06291152,0.01216375,-0.034063317,0.014323076,0.009569151,-0.041015085,0.009767331,0.0634693,0.06306915,-0.029554075,0.020784084,0.034450755,-4.2281954e-08,0.054114833,-0.06240795,-0.008168733,-0.076013684,0.009001629,0.033040166,0.07595118,-0.047804866,-0.0293566,0.06748726,0.008971338,0.059935052,-0.017672265,0.014904804,0.057591904,0.0050547156,-0.015112844,0.04033298,-0.023746885,-0.003234008,-0.061261103,-0.0005554433,-0.18515216,-0.030563101,0.034271218,-0.03622764,-0.013795584,-0.072410986,-0.0059356084,-0.055820037,0.021166693,-0.020077784,0.032354794,-0.06733741,-0.0140636405,0.11290614,-0.034981284,-0.0048660496,-0.06345289,0.0597642,0.038144913,-0.084968284,-0.031930055,-0.012875337,0.03158786,0.0351307,0.047636878,-0.039698433,-0.06446455,0.037075948,0.082879424,-0.008724279,0.11044503,-0.11375456,-0.107048444,0.09594466,-0.0009927541,-0.11196816,-3.6128447e-05,-0.10798536,0.026248656,-0.053436875,0.14839403,0.01939451 +1.3.5.4,"The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, succinate dehydrogenase (quinone), to which it is closely related.",384,1.0,-0.059740618,0.041783992,-0.10555606,-0.03225786,0.089017905,-0.05711083,-0.05969141,0.048234016,0.034759123,0.036127467,0.015897451,-0.0922478,-0.041997712,0.04355445,-0.058136094,0.01929869,-0.0606006,-0.03550423,-0.011352024,-0.04188785,0.054369174,0.015903767,-0.08525972,-0.039071787,0.0024098328,-0.0070028678,0.0012484806,0.027558323,-0.107067056,-0.031468038,0.031798527,-0.024532149,0.059424564,-0.045447867,-0.037165165,0.18207219,-0.050915655,-0.034469925,0.0741109,0.068585224,-0.011998394,0.023577303,0.006489671,-0.00018836946,0.020082496,0.017296722,-0.018056586,0.014614686,0.03987282,-0.0033284635,-0.06816479,-0.049519956,-0.029979745,0.052643612,0.027149484,0.05375935,-0.040706966,-0.0154431695,-0.09730811,0.01920956,0.026193993,-0.01023407,-0.0006726302,-0.03598504,-0.053654086,-0.0164598,0.030839605,-0.051324587,0.041953217,0.018777994,-0.04147068,-0.07177796,-0.012286666,-0.035101507,-0.005242531,0.022006629,-0.018857205,-0.045570157,0.050373595,-0.04076481,0.00046718368,-0.019183027,-0.035221357,0.01902513,0.04147359,0.018222257,0.050591126,-0.07280972,0.007911191,0.064873725,0.035685178,-0.005677754,0.00050137413,-0.10991861,-0.04439293,0.06976462,-0.012762954,0.08292953,-0.00083537406,-0.033121746,0.033460416,0.026571821,-0.032545,-0.12847844,-0.05031649,0.037827693,0.095671035,0.100991786,0.013464394,-0.0010997178,-0.061395884,0.011880423,0.07265236,-0.003918792,0.0091136545,0.13820343,0.03810854,-0.055173434,-0.06356871,0.017306387,0.010484981,-0.03489098,0.06674892,0.009582474,0.0151226735,0.028774472,-0.054280832,1.4062539e-33,0.014494461,0.0041430844,-0.007212941,-0.024310337,-0.017445637,-0.022709055,-0.11001082,0.03994717,-0.02508641,-0.042328198,-0.06949082,0.0056581707,0.018763108,0.007086188,-0.06424812,0.0028193034,-0.022011457,-0.055030007,0.050953534,0.0055565434,0.022114463,-0.0031929777,-0.024549823,-0.08379149,0.040187914,0.052835874,0.034325212,0.0066605983,0.0034757808,-0.012260925,0.047786728,-0.07528855,-0.046154637,0.011872154,-0.005598466,0.06692949,-0.07596679,0.012105265,-0.07427828,0.06769261,-0.0028961494,0.09707541,0.011292301,0.011141749,0.060098402,-0.03353692,0.0052704937,0.099943824,0.06677822,0.032822646,0.05189141,-0.034234636,0.0816218,-0.08165873,-0.025478225,0.044835143,0.02684345,0.054301914,0.024642786,0.06664994,-0.0027745052,0.055345133,-0.04574361,0.05541617,0.05452129,0.025743557,-0.05354913,-0.06715191,0.0653119,0.08242134,-0.053927258,-0.005394734,0.051462125,-0.028022569,0.04984743,-0.008180168,-0.085238226,-0.05717085,-0.024098523,-0.032857586,0.018583845,-0.085661374,0.052084878,-0.031406324,-0.04185525,-0.060102247,-0.015690371,0.012576635,0.041425366,0.00435395,0.03677173,-0.07228213,-0.06209835,-0.024253296,0.078183606,-1.4269258e-33,0.08517809,-0.0960978,0.0060773427,-0.033226673,-0.037716243,0.16327484,0.051794007,-0.03106976,-0.030153897,0.003461357,0.07062153,-0.03352139,0.071976215,-0.015744107,0.08111935,-0.0232168,-0.03349866,-0.032326914,0.036436033,-0.029110966,-0.035132803,0.09364805,0.065610185,0.024339808,0.04183927,0.048316445,-0.042584214,0.06636103,0.014969675,0.029024355,-0.05334767,-0.0022842363,-0.004836906,-0.010122518,0.022019252,0.0363657,-0.056788515,0.057010036,0.024759632,0.0052283835,-0.015782937,0.013006674,0.027620748,0.0122481305,-0.029645704,0.10306327,-0.12514111,0.017870018,-0.018347139,-0.045569587,0.012021454,-0.0058156988,-0.10034046,-0.01338879,0.086104594,0.0665846,-0.05810018,-0.011648359,0.036125477,-0.03198916,-0.079143405,-0.07656886,0.013524364,-0.043353897,-0.0057315305,0.052945428,-0.03339619,0.08039504,0.028790146,0.0034686995,0.066096455,0.03252676,0.02242361,0.017351277,-0.07682865,-0.03857731,-0.0037756963,-0.0034008482,0.005702335,0.002215758,0.046874028,-0.008926102,-0.04663549,-0.07801873,-0.028300293,-0.09651548,0.008438764,0.08758283,-0.024864746,0.03644982,-0.018790605,0.041378304,-0.06349211,0.024910897,0.067462645,-3.7764597e-08,0.022594316,-0.06419592,0.08636097,0.030788971,0.02864917,0.013389699,-0.015888358,0.019131944,0.03223186,0.053250216,-0.01007693,0.06576558,0.047634788,0.012805353,0.067822896,0.03249636,-0.005994892,0.018730396,-0.016078925,0.009523386,-0.0452972,-0.021714706,-0.18842852,0.037423696,0.04605782,-0.056840356,0.07533398,-0.017810805,-0.050312,-0.029011734,-0.059606135,0.059188116,0.003618336,0.027446631,-0.08267597,0.057205368,-0.03908896,0.0110960025,-0.07505165,-0.024193121,-0.0045329602,-0.052566927,-0.09991267,-0.009036039,0.03693894,-0.01797397,0.058738086,0.010348835,0.020744838,0.0028666577,0.02141701,-0.04621579,0.069445014,-0.005721887,-0.08822324,0.054984655,-0.02585178,-0.08703871,-0.024777353,-0.027499331,0.060323086,-0.004313226,0.17437938,-0.025345698 +1.3.8.10,"Contains FAD. The enzyme, characterized from the strict anaerobic bacterium Syntrophus aciditrophicus, is involved in production of cyclohexane-1-carboxylate, a byproduct produced by that organism during fermentation of benzoate and crotonate to acetate.",384,0.99999994,-0.03730253,-0.054096866,-0.06904614,-0.0061811716,0.08200535,0.05440981,-0.031953286,0.031140793,0.008585831,-0.038059276,-0.015970822,-0.110013306,-0.03076951,0.01590419,-0.10425032,-0.010208713,-0.028802305,-0.08333829,-0.0076846695,-0.06702172,0.041764762,0.04050247,0.0167966,0.018875116,0.008579125,-0.053835686,-0.018899582,-0.023304978,-0.032676548,0.02731147,-0.020275328,0.05158643,0.049475335,-0.0014251312,0.07376571,0.08417751,-0.004379647,-0.029107215,0.092676595,0.050420757,-0.015311557,0.007531692,0.008799565,0.006839585,0.03600254,0.05160674,0.031518478,-0.00061854604,-0.01682896,-0.07335779,-0.028236615,-0.001537594,-4.2867585e-05,-0.010548696,0.004763884,0.037708182,-0.0056542447,-0.052090615,-0.03813524,0.018134518,0.032344103,0.06417006,-0.009780183,-0.01852261,0.028057693,-0.076199606,-0.013755927,-0.014536603,0.023616372,-0.0015159182,-0.06951823,-0.08290702,-0.020179966,-0.011335438,0.017887628,-0.021056304,-0.04631826,-0.09552831,0.0062913513,-0.06530592,0.0599408,-0.011664548,0.04383817,0.019374654,0.04586144,-0.022558972,0.06670016,0.031142173,-0.0023141294,0.041448314,0.0037923797,-0.0476847,0.004178189,-0.09391847,-0.061357107,0.032142796,0.046194095,-0.012876085,0.041440234,-0.021227393,-0.0059741354,0.07657245,0.07578304,-0.088939585,-0.06245622,-0.026029272,-0.001180973,0.16263679,0.025149118,0.020004323,-0.018321032,0.010720634,0.00586558,-0.045954358,-0.012834121,0.047232594,0.0013856759,-0.08401907,-0.039812554,0.005033161,0.00959819,-0.04558658,0.015304909,0.11617925,0.009760901,0.029441793,-0.12545605,5.1391184e-33,0.08444805,-0.03564815,-0.053734414,-0.06198835,-0.01706983,-0.0072308625,-0.10053335,-0.012404428,0.02865885,-0.006091601,-0.03064919,-0.06695645,0.016889874,0.010038603,-0.031626575,0.021645585,-0.14983872,-0.004437198,0.027849816,-0.017280823,-0.030097665,0.082538545,-0.015248278,0.032823417,0.032461774,-0.009014445,-0.03315473,0.021025067,0.041435458,-0.010558897,0.016780246,-0.062201235,-0.09856903,0.014896384,0.018715246,0.012290755,-0.08371163,-0.07166962,-0.04743057,0.07232046,0.06501513,0.036060236,0.058031913,-0.0517741,0.048905477,-0.020620331,-0.07254497,0.11549254,0.027095892,0.05429763,0.042382568,-0.0098970095,0.081575125,-0.028130723,-0.033922564,0.042335883,-0.0453211,0.04641969,0.067929484,0.04968595,-0.012715222,0.033705696,-0.058479887,0.085157685,-0.038566936,0.010687471,-0.056413982,-0.032832146,0.008525631,0.098007955,-0.065150365,-0.074395545,0.012874692,0.075851455,0.08411585,-0.06352664,-0.02748536,-0.038853902,-0.0016461952,-0.019408908,-0.023709549,-0.067545705,-0.006434786,-0.045957994,-0.05728683,-0.0009744523,-0.06286264,-0.008179633,0.014199152,0.04075524,-0.0055639558,-0.08942302,-0.010928447,0.09350646,0.0148408385,-5.9786488e-33,0.085308835,-0.06347184,0.09159763,-0.08862475,-0.0085262675,0.100803114,0.004506995,-0.04189968,-0.0042815534,-0.03648136,0.055276893,-0.004044666,0.0035075552,0.007922326,-0.011564705,-0.024709826,0.03397597,0.06822,0.003046597,0.07684378,-0.048908744,0.044259988,0.05502428,0.016377388,0.050431762,0.04715768,-0.048337832,0.0874709,0.025394147,0.016556375,0.036166914,0.037853368,-0.034812056,-0.07539142,-0.12260306,0.03368249,-0.027527615,-0.001520678,-0.02882256,0.054093845,0.0095511945,0.018371148,-0.052337904,0.11427105,0.045213684,0.025987724,-0.11252635,-0.032067336,0.05794357,-0.04736344,0.009681725,-0.0123853125,0.030282136,-0.07486241,0.05334772,0.081025615,0.02054723,0.02427752,-0.008608521,-0.015060835,-0.020679371,-0.023535673,0.04022394,-0.041305594,0.08732356,0.0029676869,-0.014983606,0.108741865,0.042734835,0.045795318,0.09429278,0.08953211,-0.020410022,0.066917844,-0.03698661,-0.0036521878,-0.055859905,-0.022572927,0.055748887,-0.010239383,0.027189279,0.030275831,-0.011996915,0.033817988,-0.08235701,-0.09080133,-0.0044774455,0.06549768,0.0014851756,0.016190032,0.0029404818,0.0017652519,0.008650557,0.034145515,0.0692389,-4.114556e-08,0.07857083,-0.08087185,0.035683136,-0.06366442,0.008030218,0.025828326,0.029949712,-0.024461018,-0.018548286,-0.07189365,-0.047622133,0.07153485,-0.012680588,0.011586893,0.038820878,-0.015688987,-0.08045105,0.05638401,-0.062868744,0.05111073,-0.053031627,0.012967901,-0.08596592,0.074473344,-0.036306415,-0.057085376,0.07762414,0.04482546,-0.030439662,-0.008427636,-0.008076235,0.03148513,-0.0028133886,-0.015432987,-0.08223998,0.013935881,-0.013612319,-0.07412953,-0.09451758,-0.032750405,0.0134279225,-0.0019027226,-0.076272406,-0.052370153,0.039619025,-0.020109395,-0.021181073,-0.026169604,-0.04081556,-0.026743837,0.060972538,-0.027709208,0.018130422,0.005024195,-0.052757874,0.0016822414,-0.020108625,-0.07956818,-0.001904942,-0.057876788,0.024806924,0.069493,0.2358496,-0.032877292 +1.14.12.22,"This enzyme catalyses the first reaction in the pathway of carbazole degradation. The enzyme attacks at the 1 and 9a positions of carbazole, resulting in the formation of a highly unstable hemiaminal intermediate that undergoes a spontaneous cleavage and rearomatization, resulting in 2'-aminobiphenyl-2,3-diol. In most bacteria the enzyme is a complex composed of a terminal oxygenase, a ferredoxin, and a ferredoxin reductase. The terminal oxygenase component contains a nonheme iron centre and a Rieske [2Fe-2S] iron-sulfur cluster.",384,1.0,-0.03591811,-0.026911892,-0.082812555,0.05034128,0.07688185,-0.018037874,-0.045424838,0.06673854,0.05295938,-0.039530337,-0.038897242,-0.046371303,-0.011489442,0.020525463,-0.046505384,0.017458579,-0.070425905,0.035550985,-0.01782824,0.001916299,0.004297574,0.044940613,0.0024284949,-0.04742079,-0.04005467,0.03740631,0.10790579,0.062017865,-0.07034305,-0.1198203,0.039573085,-0.053021386,0.041080724,-0.029767515,0.04111262,0.049941786,0.011856917,-0.077388495,0.0033133542,-0.024644516,-0.021283135,0.035683148,-0.027379049,-0.056587785,-0.022571921,-0.06636001,0.03424405,0.04300495,0.06516777,-0.067335956,-0.08272056,-0.021969035,-0.008382804,0.08030585,0.0022826707,-0.00011197691,-0.0035179409,-0.020416316,-0.016257808,-0.016138151,0.06366522,0.0011865342,-0.025341298,-0.01975862,-0.027528232,-0.01296957,0.027189802,-0.08851065,-0.039847504,-0.0030092825,-0.09106055,-0.03739334,-0.019251855,-0.06796354,-0.015556713,0.004407191,0.035742793,-0.0066061625,0.060687207,-0.06003771,0.024577683,-0.055553615,0.11342872,0.07369861,0.023656236,-0.004489466,0.023753852,-0.0643691,0.05613276,0.045573138,-0.0126483105,0.08358152,0.070534945,-0.017501941,-0.04154985,0.020792091,0.02692924,0.08876676,0.065272085,0.0040629534,0.009313342,0.058833912,-0.00276992,-0.09556721,-0.04284253,0.0643757,-0.007942009,0.13183835,0.069867685,-0.0318253,0.017772952,0.0076111644,0.043818973,-0.0016755911,-0.039670054,0.0765711,0.11024044,0.0040909606,-0.050967183,0.06771589,0.053195465,-0.024757102,0.057385862,-0.05505459,-0.05434283,0.010958313,-0.1348632,1.2769551e-33,0.022876848,0.028209668,-0.045416582,0.0056377007,0.0036332996,-0.0063425046,-0.14023596,0.013080215,-0.044277746,-0.017559102,-0.076987654,-0.047077898,0.031186467,-0.058349587,-0.023813592,-0.05385088,-0.028087527,0.0056977617,0.010098336,-0.006726434,0.028149113,0.036906667,-0.038363323,-0.019692425,0.035931505,0.08032083,0.042127036,0.02662487,-0.018921044,0.011791092,0.032669548,-0.08761128,-0.14811568,-0.03019402,0.055007197,-0.028803304,-0.022274954,0.011262376,-0.018748522,-0.026616907,-0.0051626572,0.012447732,-0.038279627,-0.040565822,0.08218529,-0.0886155,-0.012540339,0.14094016,0.042328335,0.090402395,0.0072728004,-0.073061846,0.089643784,0.018133406,-0.074564874,0.03559039,-0.008730437,0.016535752,0.08903008,0.032452393,0.058745377,0.07831284,-0.029831033,0.06701212,-0.0002361992,0.0031348115,-0.031798374,-0.02158663,0.061355866,0.104972765,-0.04862718,0.044047706,0.102728866,0.0075578047,0.016327666,-0.05237233,-0.04658406,-0.019696675,0.12462628,-0.0027772768,0.015311569,-0.062144812,-0.0018909634,-0.042301863,-0.02840088,0.0038602073,-0.08149495,-0.04887608,-0.12295644,0.080881186,0.064445935,-0.055386636,-0.08461534,-0.038520474,0.042966187,-1.9350037e-33,0.09365105,-0.041083563,0.019052245,-0.052658785,-0.042058006,-0.020994648,-0.011194627,0.023338675,-0.017867161,-0.025297701,0.050385308,0.0005999161,0.04482479,-0.033831734,0.033663224,-1.3273149e-05,0.049999755,-0.0043508536,-0.010277265,-0.092673175,0.012579979,0.036217354,0.0025268097,-0.014152192,-0.0060696253,0.013139361,-0.03748674,0.04041118,0.064910054,0.09635534,0.010218372,0.025922844,-0.005961174,-0.05379818,-0.053657953,0.030876566,-0.061586913,-0.051807784,0.057162855,-0.029615296,-0.020429706,-0.03863893,-0.015797019,0.07243276,0.043972053,0.07130556,-0.05136654,7.7731536e-05,-0.02436522,-0.040923953,0.019982751,-0.019281879,-0.02436384,0.011691956,0.0066049187,0.043994386,0.05293841,-0.00641536,-0.07057323,0.09692483,0.014091963,-0.012764413,0.09337162,0.069537744,0.038364552,0.035280216,-0.036108132,0.093744606,0.0791884,0.010690817,0.08360259,0.03081352,0.020735126,0.038208336,-0.05935819,0.044892028,-0.028074505,0.030860798,-0.005720692,-0.0064567537,0.0073176753,-0.051126942,0.00960777,-0.035271376,-0.033587974,-0.14389217,0.012330411,0.06803562,-0.0052227983,0.02159468,-0.0028606025,-0.0042108884,0.0033903238,0.056742076,0.011797399,-3.9101806e-08,-0.016621506,-0.099472135,0.05026548,-0.06501632,0.04903884,0.07481582,-0.038894422,0.023013176,0.031300765,-0.02980025,0.015585557,0.08871076,-0.017177723,0.018859923,0.026014045,0.101655155,0.018070681,-0.034314096,-0.0159466,-0.0061031827,-0.058285024,-0.012626752,-0.08500869,0.048283212,0.04139588,-0.09814711,-0.04479382,0.00052068505,-0.017711295,-0.060158215,-0.017802684,0.043805663,0.015859734,-0.025692634,-0.09897585,-0.0044248383,-0.07773265,-0.051625818,-0.05490219,-0.035340995,0.058021188,0.043616414,-0.08367655,0.0011468417,-0.03085204,0.0324697,-0.0014991132,0.036176037,-0.062315155,-0.09485091,0.024402373,0.019585762,-0.044171162,-0.00521709,-0.113374375,0.083455,0.008988995,-0.010120863,0.028868122,-0.019225007,-0.013259201,0.047260344,0.07651499,-0.012675613 +1.14.13.116,Contains cytochrome P-450. ,384,1.0,-0.055932116,0.024883406,-0.008565166,-0.02722488,0.05770662,0.035673026,0.024076004,0.076335505,-0.04533384,-0.003002489,0.015065236,0.007563828,-0.010217683,0.053714376,-0.032102473,0.0010269557,0.001967849,-0.054535087,0.0149671985,-0.0396849,-0.033292066,0.016267363,0.10847654,0.035633985,-0.04999696,0.080403544,0.0016151846,0.11189983,-0.013521491,-0.009740185,-0.05501612,0.06717906,-0.0075847832,-0.012047724,0.019804116,0.039753634,-0.096727744,0.0074073896,0.04161328,-0.00069116766,0.07011131,-0.050765503,-0.03710304,0.07548843,0.037345856,-0.063518204,-0.068920776,-0.015601883,0.037112072,-0.015301353,-0.0140497675,-0.023399841,-0.040709175,0.01991637,0.025585264,-0.03135711,0.01148009,-0.053096417,-0.030436521,0.0061685047,-0.05481633,0.022788387,-0.033002447,0.048600975,0.043896217,0.032714874,0.01564276,-0.054336153,0.0034814852,-0.046527512,-0.023186356,-0.06626383,-0.017250441,0.081726536,-0.106590375,0.077580154,0.041613303,-0.04197263,-0.023098707,0.00077231106,0.0015224245,-0.014739616,-0.007138816,0.11530934,0.08370472,-0.0071985233,-0.022686359,0.04628615,-0.12629403,-0.03328749,-0.029776387,-0.017978014,-0.02863992,0.009801478,-0.101141594,0.053780884,-0.027174205,0.033491813,-0.044332266,-0.0082037775,0.015005343,0.040062558,0.016334774,-0.107335635,-0.09364745,-0.011843243,0.01977414,0.057841334,0.050055124,-0.07107295,-0.074839644,-0.031051656,-0.022699496,0.0045159804,0.0041594026,0.009005931,0.057410374,0.031617675,0.031967875,0.017950466,-0.017635189,-0.03378886,0.03804459,-0.011708209,-0.05662513,-0.011524696,-0.04194415,-9.4098897e-35,0.07074095,-0.0016911218,0.021316871,0.05777738,-0.017470282,0.07956946,-0.04166475,-0.0023852002,-0.034091342,-0.033766035,-0.1032415,-0.048365396,-0.036588978,0.016509824,-0.029099133,0.04213978,-0.043680973,0.021829292,0.047993716,-0.048577305,-0.058655232,-0.008220116,-0.026430015,-0.032245427,0.007373451,0.092831716,-0.046963975,-0.02214226,0.016176028,0.0086047705,-0.030456532,-0.029254377,-0.05521961,-0.008976156,-0.029728098,0.076075844,-0.024817366,-0.024742624,-0.029364541,0.057918973,-0.015739724,-0.03428388,0.039099846,-0.023068339,0.061323892,-0.027610276,-0.16001631,0.02994073,-0.049839173,0.028346844,0.047794517,-0.012647674,0.027231334,0.045356978,-0.08987157,0.01747279,0.024134243,0.052211355,-0.0062742964,0.08274584,0.10842332,0.111301444,-0.032882735,0.06804722,0.081767075,0.05771204,-0.04992446,-0.044661466,-0.045983512,0.12506826,-0.03297045,-0.013610225,0.13276432,0.004947793,0.042766724,-0.0015812707,0.004598912,0.103376836,0.043739747,0.045695685,-0.03567702,-0.08828246,0.03603641,0.026560565,-0.02315645,0.01727904,0.03955807,-0.045949038,0.033642426,-0.011099954,0.059691407,-0.104145646,-0.041909635,-0.024744159,-0.08916907,-4.53575e-34,0.04124578,-0.07934192,0.06557214,-0.05704715,-0.07452647,0.050437976,0.04233594,-0.0662159,-0.015376672,0.028852236,0.13828892,-0.062827274,-0.006850326,-0.060329057,-0.0028344719,0.011471834,-0.008634118,0.06731231,0.014951209,0.03793801,-0.0070894784,0.018366784,0.045341447,0.042002726,0.027659224,0.038471784,0.039291404,-0.029049164,0.042837583,-0.048716042,-0.07854788,0.04985568,-0.11719463,-0.03448499,-0.036360387,-0.008893388,-0.02395257,-0.03750991,-0.025415298,0.016806984,-0.033241834,0.082870886,0.02462085,0.10556257,0.03383684,0.09287806,-0.021126244,-0.02697141,0.019430606,-0.013899895,0.051459216,0.005229781,-0.03240258,0.042445462,0.0041644163,0.027715145,-0.021772271,-0.035924062,-0.004854904,-0.057512134,-0.012488358,0.017167073,-0.06377411,0.069749996,0.053955175,0.0795924,0.02248193,0.045497056,0.0043549524,-0.016166694,0.044067543,-0.0040845773,0.06897195,0.065544195,-0.044768192,0.050790355,-0.020574274,-0.001325859,0.077979594,0.0014471296,0.011629447,-0.03843111,-0.116177544,0.013389044,-0.012705645,-0.08795847,-0.076234184,0.037477806,0.043815225,-0.05775857,-0.01924181,0.08468131,-0.07916254,0.012395,0.048795175,-1.6664215e-08,0.09433976,-0.028969841,0.039427377,-0.022731086,0.060222346,0.026500093,0.03927802,0.017336132,0.06407579,-0.00988437,0.023066495,0.02887113,-0.031665564,-0.0048237923,0.004138846,0.016045304,0.021834023,0.034675576,0.028203879,0.043868788,-0.11066031,-0.010273288,0.019263444,0.013002481,0.019229444,-0.06827275,0.01895725,0.028154295,0.09418464,0.010352418,-0.019562004,-0.020523025,-0.05177401,-0.033909872,0.029480815,0.0064369966,0.014862173,-0.04824735,-0.062343925,0.048341267,-0.051050406,-0.12450354,-0.032508112,-0.015578074,0.026091427,-0.07441585,0.024423499,0.018879093,-0.04014425,-0.05073827,-0.021088397,0.030037167,0.026245536,-0.08758375,-0.1674396,0.022137567,0.08247257,-0.09870968,-0.012158609,-0.10260233,-2.5007388e-05,-0.031849135,0.1625376,0.036745492 +1.14.13.117,"A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-isoleucine, the first committed steps in the biosynthesis of the cyanogenic glucoside lotaustralin in the plant Lotus japonicus. The product of the two hydroxylations, N,N-dihydroxy-L-isoleucine, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The product, (E)-2-methylbutanal oxime, undergoes a spontaneous isomerization to the (Z) form. The enzyme can also accept L-valine as substrate, with a lower activity. It is different from EC 1.14.13.118 (valine N-monooxygenase), which prefers L-valine.",384,0.99999994,-0.09033727,0.0014636819,-0.013276426,0.00475532,0.09462523,0.0415264,-0.05232168,0.08133924,0.0012465072,-0.10375576,0.036996823,-0.04554003,-0.063243166,0.007490037,-0.062567376,0.042596187,-0.05817386,0.016850285,-0.033709563,-0.055049136,0.042289853,0.05751529,-0.043419797,-0.009245375,0.04072826,-0.015481862,0.016911246,0.000113146685,4.3665274e-05,-0.085060365,0.0032566928,-0.015562337,0.06216912,-0.015909396,0.03016153,0.0580775,-0.029550452,-0.10437974,0.04377612,0.026482306,0.068794884,-0.042780805,-0.07807535,-0.0064947256,-0.02846797,-0.007596825,0.0017988413,0.011523076,-0.030207582,0.0062395995,-0.01521357,-0.06399011,-0.02360522,0.059528653,-0.097938,-0.048874043,0.02845098,0.12868686,-0.04517244,0.017506283,-0.0063134665,0.07517254,-0.06515666,-0.029506957,0.017286757,-0.04540567,-0.015421125,-0.06428414,0.030932195,-0.057433918,-0.025461897,-0.044081878,-0.030834269,0.0045117647,-0.10750645,0.05712229,-0.03395311,0.019564537,-0.010691067,0.015910286,0.035319693,0.057844877,0.008743986,0.05296254,0.045368955,-0.0054451544,-0.0726381,0.07422281,0.0055108867,0.0010185052,0.04756854,0.006626688,-0.058348626,0.07215445,-0.054383293,0.09524401,0.10157761,0.026192794,0.026832554,0.019355956,-0.034427598,0.05192653,-0.06916375,-0.09622804,-0.0318875,0.03897398,-0.02112997,0.008062439,0.04632372,-0.011329658,-0.07268659,-0.031895757,0.076198205,0.035157375,-0.0510842,0.07737094,-0.020212132,-0.021209694,-0.058368057,-0.099831,0.0651894,-0.063749254,0.076080985,0.04614036,-0.05046361,0.05542125,-0.101808764,4.140567e-33,0.08644831,-0.04147927,0.02873228,0.033455987,-0.028630696,-0.029772926,-0.08981101,0.09210858,-0.011616293,-0.03166009,-0.08656871,-0.05418701,0.032909248,-0.030640904,-0.029087834,-0.04409922,-0.05420423,0.0007179272,0.0859221,0.026977113,0.019914873,0.0046005566,-0.064809605,0.009168697,-0.061683897,0.051561777,0.05290466,-0.036424153,0.022180613,0.0075315665,-0.039802793,-0.15485944,-0.001695578,-0.0027651761,0.0066034715,0.0026401365,-0.03041414,-0.014720851,-0.034131657,0.022548629,0.0013089054,0.035305034,0.034385946,-0.040301684,0.06587818,-0.028218891,-0.06224445,0.052491926,-0.014386756,0.028929196,0.02585949,-0.018898992,0.08770707,-0.011858529,-0.00054619106,0.038760085,-0.015043877,0.04496654,0.041475117,0.09380803,0.06534347,0.09196007,0.01301451,0.014295316,-0.023399109,0.04440132,-0.1431287,-0.06709873,-0.0043615685,0.0720199,-0.030821184,-0.030671278,0.10022273,-0.010453325,0.048924584,-0.0862795,0.010118351,0.07478784,0.051650286,-0.027991468,0.0039403676,0.057576958,-0.03734721,-0.024498086,-0.009586949,-0.015473611,-0.010763045,0.02331889,-0.04629548,0.0746211,0.05718993,-0.04367856,0.025566932,-0.00097084825,0.038193032,-2.9079583e-33,0.07021035,-0.045540255,-0.014083123,-0.0597146,0.0068678493,0.03579707,0.0013847649,0.013107092,0.037799485,0.021890013,0.044423386,0.027438533,-0.0016382204,-0.0006574548,0.016717888,-0.0046742414,0.014064723,0.083579384,-0.042438157,0.013192165,-0.0007593454,0.065894395,-0.024043867,0.006394824,0.040869247,0.007460007,0.0107494965,0.07761503,0.058455262,0.07793039,-0.011828422,0.031861532,-0.059144333,-0.031578418,-0.03489846,0.04284661,-0.040748667,-0.00068587554,0.020621687,0.05106606,-0.04265824,-0.009058848,-0.015595101,0.033523414,0.07174578,0.057037946,-0.1189223,-0.07631543,0.027205812,-0.020827675,0.030055,0.022089206,-0.07160754,0.046905566,0.013688848,0.045961447,-0.016684834,0.046361674,0.02067095,-0.057257988,0.0033336952,-0.02725459,0.018260192,0.008053699,0.009972973,0.058404826,-0.0059940326,0.07960367,0.056069337,-0.00035536572,0.09921105,0.019712968,0.014185929,0.06367624,0.010300149,-0.063525036,-0.029404847,-0.06596824,-0.031679653,-0.044405505,-0.04108213,0.012888096,-0.04293889,-0.12767904,-0.033814933,-0.09024567,-0.027312782,0.09646076,-0.0046858746,0.005410399,-0.006324927,-0.044709407,-0.069954716,0.10229356,0.12569237,-5.009455e-08,-0.046883304,-0.12980835,0.012728867,0.0035201737,-0.013544889,0.007653417,0.047976926,0.034922004,0.06688211,-0.043589905,0.050373804,0.051920496,-0.055688217,0.032431934,0.0011436816,0.014009786,0.01949776,0.043237235,-0.022963021,0.053641953,0.0056121177,0.022116728,-0.050027084,0.010929375,0.010009679,-0.097736195,0.013438951,0.05971415,0.048176255,-0.046189204,0.019386135,0.08230116,0.060211316,-0.043728605,-0.062077865,0.027660038,-0.04021764,0.00066206505,-0.03781308,-0.009414588,-0.0383087,-0.055834804,-0.086677715,0.0021672456,0.059902623,-0.015019892,0.087270945,0.017735593,0.011147416,0.035071325,0.07800529,-0.0413645,0.03392787,-0.08464109,-0.07152471,0.031280644,-0.0057251384,-0.031713214,0.02239513,-0.058249857,-0.0058947415,0.014821186,0.22958116,-0.010208481 +1.14.13.118,"A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-valine, the first committed steps in the biosynthesis of the cyanogenic glucoside linamarin in Manihot esculenta (cassava). The product of the two hydroxylations, N,N-dihydroxy-L-valine, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The product, (E)-2-methylpropanal oxime, undergoes a spontaneous isomerization to the (Z) form. The enzyme can also accept L-isoleucine as substrate, with a lower activity. It is different from EC 1.14.13.117 (isoleucine N-monooxygenase), which prefers L-isoleucine.",384,1.0,-0.076556996,-0.027269656,-0.051587492,-0.015003874,0.120501906,0.015245543,-0.045753323,0.100289986,-0.027825207,-0.07056396,-0.003987092,-0.037428714,-0.0643848,-0.00016592788,-0.07819484,0.0032313655,-0.053936318,0.013562057,-0.028364552,-0.048232287,0.04227148,0.04120719,-0.0509284,0.012743494,0.039000865,0.008617619,0.083705805,0.019872414,-0.023381328,-0.10006977,0.028150782,-0.033375286,0.026771102,-0.034061376,0.022041561,0.08079816,-0.012133667,-0.07785252,-0.0030623341,0.014450758,0.06556562,-0.05935104,-0.06793893,-0.017602079,0.012902866,-0.07050034,0.005317077,0.019057773,-0.06370035,0.003551942,-0.01960459,-0.03625966,-0.06391685,0.067258775,-0.075284556,-0.05954715,0.0014696559,0.041587465,-0.021711342,0.0152671365,0.00058236904,0.06436338,-0.07043451,-0.03520982,0.040565055,-0.076252885,0.052330077,-0.08121332,0.007196579,-0.07801684,-0.017174168,-0.046916123,-0.035294414,0.035196893,-0.103769735,0.06155553,-0.0022098187,0.0011590314,-0.006011063,0.036822475,0.021481857,0.06363175,0.040459946,0.058753334,0.034355603,0.0016910152,-0.09580237,0.08417611,0.036338694,-0.006977711,0.01291537,0.033736035,-0.05186152,0.07231036,-0.03137347,0.08091283,0.09774234,0.0413242,0.020975454,0.034279685,-0.039053056,0.026074918,-0.10724925,-0.05488387,0.00045126365,0.04340137,0.020034151,0.058904774,0.034203604,0.011544192,-0.043110512,-0.0068500135,0.039639864,0.011985384,-0.053115707,0.13219102,-0.025873492,-0.01749747,-0.022344125,-0.09283975,0.036683045,-0.0047451016,0.08032641,0.05538013,-0.05843147,0.03393615,-0.076569304,4.064601e-33,0.07150062,-0.022566507,0.051745456,0.03620641,-0.018722882,-0.0030982033,-0.10959762,0.089506894,-0.0062934947,-0.05697938,-0.06987379,-0.03492366,0.07546965,-0.0020403205,-0.041694365,-0.05195006,-0.015831184,0.03569798,0.025631646,0.0071565905,0.0022673814,0.005020456,-0.06325581,0.04637449,-0.0504492,0.05335371,0.023866903,-0.028234836,0.027085045,0.024994846,-0.068712205,-0.13582957,-0.001985072,0.0017018445,0.036481485,0.0016424378,-0.047347408,0.00078356464,-0.0045945197,0.047864918,0.009237681,0.017483212,0.0129585145,-0.05858579,0.053663604,-0.083537444,-0.031553205,0.05035535,-0.04150847,0.020773573,0.033015717,-0.009407356,0.07041017,0.01958448,-0.032474924,0.0386212,-0.033854015,0.021015665,0.06772419,0.09354689,0.09215529,0.101242945,-0.005932484,0.009823736,-0.026684387,0.037154883,-0.11680798,-0.053635877,0.020973891,0.07232434,-0.060619306,0.0036603927,0.093986936,-0.0052381703,0.06871766,-0.08465181,0.022111371,0.09052708,0.040204953,-0.028597998,0.012619462,0.038737763,-0.029728463,-0.0176392,-0.033264242,-0.0068221414,-0.010529278,0.010475982,-0.059147384,0.07566786,0.031970017,-0.046053246,-0.004948216,-0.019576397,0.040747017,-3.3517734e-33,0.10517527,-0.07325014,-0.044027466,-0.041119285,-0.0053755133,0.0032067134,0.037637204,-0.025209935,0.0069858944,-0.030924829,0.08735628,-0.020295233,-0.010080362,-0.027487328,0.0024625505,0.021417262,0.002653232,0.068220414,0.00063360535,0.012520761,-0.0010260532,0.077226505,-0.04419546,0.0032515225,0.043983437,-0.034558963,0.013485013,0.035805743,0.047636077,0.09023551,-0.03411709,0.015794808,-0.06967199,-0.028417308,-0.038790494,0.07960576,-0.045631602,-0.016839664,0.015535264,0.06384475,-0.046634413,0.018767668,-0.009917958,0.050656993,0.06717231,0.08056974,-0.082528986,-0.06450876,0.032372564,-0.021068325,0.07408449,0.0042910185,-0.064062044,0.047778364,0.0014289583,0.031148272,0.02535307,0.05090895,0.0020962248,-0.031926796,0.0085398415,-0.016515166,0.018060507,-0.022209449,0.036086578,0.042417325,-0.022597045,0.07401553,0.05694855,-0.02890458,0.12511444,-0.004489358,0.016757956,0.04595764,0.003208199,-0.0665827,-0.02247515,-0.058006395,-0.030086886,-0.08818173,-0.019989489,-0.018281074,-0.010707941,-0.11749025,-0.038065977,-0.05778913,-0.014292405,0.088938795,-0.02980041,0.018642927,-0.014088685,-0.06767405,-0.06921754,0.122472465,0.12204161,-5.33059e-08,-0.03292781,-0.10150707,-0.030648686,0.031997167,-0.014002521,0.057158656,0.076028444,-0.00076796877,0.097141504,-0.052352738,0.013693811,0.06638058,-0.023774415,0.019816887,0.018424844,0.039056282,-8.165412e-06,0.039802138,-0.020383177,0.05601279,0.01995321,0.025915215,-0.048032764,-0.012252042,-0.025733469,-0.07387858,0.0044061183,0.039858557,0.088422015,-0.06985152,0.012955569,0.06633141,0.048876535,-0.047367573,-0.030577986,0.028269086,-0.040330976,-0.0005430666,-0.014868025,0.0026120176,-0.040992424,-0.03642542,-0.09591986,-0.021379245,0.04254286,0.017238667,0.04763149,0.035413776,-0.025898345,0.022250645,0.07624312,-0.006941592,0.015001521,-0.07012794,-0.060122114,0.030215247,-0.01170763,-0.087499924,0.01706461,-0.08321993,0.009504026,0.00071811007,0.2120093,-0.028588267 +1.17.5.2,"This enzyme, characterized from the soil bacterium Pseudomonas sp. CBB1, catalyses the incorporation of an oxygen atom originating from a water molecule into position C-8 of caffeine. It can also use theobromine as substrate. The enzyme utilizes short-tail ubiquinones as the preferred electron acceptor. ",384,0.99999994,-0.05475959,0.008964449,-0.09221526,0.038968094,0.06819839,0.07756612,-0.013464268,0.039598644,-0.021616543,-0.05968687,-0.03716863,-0.12344808,0.010745516,0.026264016,-0.05247018,0.049939085,-0.028658347,-0.04339829,0.053065073,-0.00016640296,-0.012952346,0.06930708,-0.021795848,0.005160632,0.031048294,0.040206455,0.06397804,-0.051320847,-0.0073149987,-0.057395227,0.049722765,-0.032473553,0.108411126,-0.056936342,0.022035725,0.08603325,-0.04529558,-0.026611362,0.05413814,0.02835938,-0.00040375488,0.004064813,0.05005565,0.029379956,-0.0071725524,-0.0065992204,0.07513879,0.023140501,0.05645582,-0.076927714,-0.019073034,-0.024202196,-0.021955635,0.12072804,0.04220353,0.034523007,-0.037383616,-0.017778052,0.027012508,0.0027377228,0.026143381,0.011177911,0.026563834,0.020995935,0.090822786,0.00035560402,-0.07115762,-0.08050455,0.04557738,-0.046101626,-0.079783075,-0.04027002,-0.026734216,-0.016882408,-0.014082756,0.00043505256,-0.022581417,0.03306971,0.096818194,-0.046573997,-0.04881163,-0.035090968,0.040926322,0.10631326,0.03193558,0.01893319,0.04154337,-0.028495243,0.048142064,-0.013549222,0.030930713,-0.010566117,-0.033557717,0.013997182,-0.09796033,0.00061971834,0.08529679,0.057341315,0.017677087,0.01951138,0.034540717,0.07517428,-0.059570894,-0.103677675,-0.03480067,0.013493934,0.00069546665,0.071588755,0.12671977,0.020629894,0.008244789,-0.01654478,-0.06501451,-0.0072079888,-0.00065642584,0.020621145,0.05458045,-0.036745958,-0.07079262,-0.014310703,-0.0068079056,-0.000520648,0.019040952,0.033893526,-0.03403646,-0.046876453,-0.118769765,2.052682e-33,0.040633876,0.0018600295,-0.03938826,-0.03754268,-0.019183574,-0.038930878,-0.0810734,0.0048874635,-0.058404353,-0.05404161,-0.04418317,0.012204302,0.019308675,0.043748144,-0.005068198,-0.089420974,-0.10293925,-0.031491976,0.07515845,0.020807931,0.010125801,0.021715002,-0.065083265,0.03200698,0.044531107,0.02721715,0.06460337,0.036402266,-0.0010430766,0.0012392208,0.0029257552,0.000902845,-0.16153698,0.01907976,-0.025593486,-0.031805497,-0.0074627176,0.008954413,-0.010851107,0.0625242,0.0018442092,0.026502213,-0.018318038,-0.025695449,0.097146764,-0.07233736,-0.033931572,0.123358175,0.03365982,0.07463346,-0.0031990728,-0.021935243,0.09698424,0.033459302,-0.061814696,0.0025551636,-0.00156692,0.03757331,0.043707334,0.0221716,0.011733477,0.06558444,-0.069233924,0.05577583,-0.07368213,-0.01754872,-0.026074829,0.0027181346,0.03848279,0.019220388,-0.063795954,0.028649084,0.07697571,0.0064625475,-0.017736576,-0.06340527,-0.08471639,-0.024375165,0.034659468,0.00013045961,0.009459952,-0.116161905,0.02624955,-0.049220163,-0.06689538,-0.01802579,-0.007128769,-0.066934474,-0.10873929,0.007855233,0.029411934,-0.05244194,-0.019713057,0.008523589,-0.010368351,-2.1404112e-33,0.12576328,-0.09713969,0.03358425,-0.051866222,0.006018008,-0.002244408,0.02509836,-0.057050094,0.0116423825,-0.03746296,0.08393881,0.032047365,0.0670595,0.0025228295,0.02189948,0.016766692,-0.024539731,0.03413292,-0.028404677,-0.01741047,0.02777699,0.007427212,-0.102995455,-0.022342497,0.011518316,0.08372773,-0.012332995,0.07473331,0.06803611,0.06963665,-0.06534985,0.068273544,-0.018744579,-0.030754134,-0.033012673,0.07838255,-0.032353885,-0.0014223475,0.026301654,0.007098317,0.012083529,0.033860628,-0.05464468,0.034933202,0.007508856,0.11052975,-0.07362233,0.029809756,0.006464671,-0.008219205,0.050079826,0.020531284,-0.06277644,0.01866194,-0.017591916,0.033056386,-0.00020029278,-0.027963364,-0.03563087,-0.012628174,0.013529436,0.007436812,0.060418632,0.0071405764,-0.031362403,0.054015514,-0.016317682,0.10166248,-0.002815941,0.023068398,0.12280171,0.042856295,0.0840799,0.0734795,-0.039059564,0.04337874,0.040587462,-0.011902006,-0.04093487,0.0014584176,0.06466097,0.019802587,0.04893901,-0.052539628,0.033745963,-0.062232327,0.018080976,0.04164055,0.008838473,0.090939455,-0.05257785,0.017770113,-0.0133478185,0.06562026,0.09243974,-3.4008977e-08,-0.060171675,-0.100295775,0.049643643,-0.025203058,0.03560231,0.0655973,0.012159052,-0.06619658,0.022645693,-0.12510063,-0.03196133,0.06378456,-0.06047673,0.041514467,0.053705376,-0.004442232,-0.013158608,-0.01597253,-0.02893288,-0.014498005,-0.08997869,-0.04894019,-0.048713144,-0.023122206,0.01410104,-0.075972654,-0.020097682,0.03822324,0.002274425,-0.013278239,-0.05676035,0.068938576,-0.05526077,-0.030449457,-0.061385304,0.042874593,-0.02015252,-0.062221814,-0.040691476,0.011564849,0.015626363,-0.05700141,-0.11221082,-0.046998214,0.027217276,-0.033725858,-0.043984927,0.02360843,0.0029161368,-0.018497545,0.08415604,-0.038287356,0.011328755,-0.041661467,-0.06645238,0.09557119,-0.07590215,-0.022430727,-0.032744393,-0.078563094,-0.062013682,0.01745934,0.17694913,-0.056461927 +2.1.1.195,"This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis. See EC 2.1.1.152, precorrin-6A synthase (deacetylating), for the C1-methyltransferase that participates in the aerobic cobalamin biosynthesis pathway.",384,0.99999994,-0.055692855,0.0463683,-0.14061269,0.029426245,0.04971101,0.067952774,-0.109094396,-0.021816684,0.02998112,-0.0018207729,-0.047116064,-0.06452266,-0.043297723,-0.043305166,-0.044700835,0.050903853,-0.07218706,-0.026435478,-0.0701651,-0.043655824,-0.02625147,0.016385822,-0.015974365,0.063340895,0.033063002,-0.05615656,0.02649591,0.02709875,-0.0008317227,0.019748196,-0.0442247,-0.00070696394,0.06554364,-0.00096468895,0.0046218666,0.11175123,0.020676319,-0.020515585,0.06497256,0.007774726,0.009616859,0.036567185,-0.016995618,0.015795976,-0.024134457,-0.018861113,0.019349601,0.050328523,-0.006607035,-0.037756566,-0.015896264,-0.029039675,-0.073834315,-0.04270593,0.03766322,0.019056376,-0.056481566,-0.073400386,0.074791536,0.0074196598,0.021691104,-0.06618735,-0.028426543,0.032885905,0.021177785,-0.019686261,0.083674416,-0.047312163,0.043826375,-0.05576769,-0.053583562,-0.10110874,-0.021193584,0.01243522,-0.040583044,0.073368974,0.017993674,-0.04562032,0.029983371,-0.04475955,-0.0086201755,0.056583714,0.0081450725,-0.0013976658,0.04199857,-0.0002989872,-0.013872534,0.015021428,0.056646045,0.06974489,-0.017409254,0.002948233,0.053315725,-0.024742432,-0.14598125,-0.005100948,0.06671983,0.060635705,0.044366468,-0.024178715,0.0500409,0.1000883,-0.04894264,0.010576631,0.038150728,-0.050839357,0.046434816,0.17087382,0.0039267517,0.0505095,0.005271842,0.07297525,-0.014581282,0.016376358,0.004813343,0.14039569,0.035585176,-0.040818818,-0.079633325,0.05122481,0.0093333535,-0.026874173,0.005767766,0.011026067,-0.058812603,-0.08780278,-0.0010817498,2.3332426e-33,0.06252731,0.023988005,0.023112375,0.0008787445,-0.013187987,0.021932036,-0.115800254,0.047439173,0.029215587,-0.033127446,0.010986505,-0.065650694,0.03976316,0.025104996,-0.093798645,-0.061179347,-0.032393333,-0.07212519,0.0135259135,0.021867093,-0.059359226,0.03634492,-0.023630016,-0.01305295,-0.0135382945,0.0670344,-0.02289575,0.052276906,0.057385527,0.0010171657,-0.009999394,-0.043188944,-0.07966096,-0.0679577,0.030539427,-0.006325694,-0.023333328,0.058931936,0.041109975,0.11077787,0.017638968,0.026569989,-0.08815503,-0.05403884,0.039459474,-0.04829164,-0.038797393,0.088294044,0.017375533,0.033317175,-0.017315358,0.0031204773,0.1003892,0.0002602264,-0.031971835,0.0024908728,0.02944767,-0.047870345,-0.027762458,0.06764453,0.0779043,0.00850989,-0.01702185,0.0748671,-0.039482284,-0.072978035,-0.06352543,-0.043724205,0.026270604,0.00018728482,-0.037192676,-0.03589913,0.046810932,0.04401068,0.007217899,0.0003163494,-0.0613434,-0.031206531,-0.013970426,-0.031076647,-0.032818012,0.035033785,0.010024429,-0.037966624,-0.061047405,0.05583292,-0.018276041,-0.061125647,-0.01975413,-0.034209307,-0.0033090205,-0.026191706,-0.044479948,-0.006122901,0.024939165,-3.8214778e-33,0.12728551,-0.08340382,0.06741294,-0.14431664,-0.032082222,0.06448193,0.059301022,-0.10838067,-0.021233937,-0.007466153,0.089804515,0.001341619,0.026098544,0.0036728943,0.017098457,-0.018759394,-0.0121913655,0.091219746,-0.019268118,0.04604545,0.010287616,-0.02440336,-0.04138706,0.01265662,0.0044538146,0.06615706,-0.027633945,0.023482772,0.08146939,0.087643564,-0.06479528,0.027747449,0.00029104858,-0.032708805,0.0011340083,0.08734445,-0.03654041,0.03183891,-0.034572046,0.0021449449,0.0013766818,0.03580938,-0.07378156,0.027870456,0.03479713,0.071713224,-0.04129997,0.054447528,-0.04574181,-0.0011989243,0.06325577,0.031203452,-0.04958557,0.058486037,0.07144804,0.015990468,0.04205155,-0.049821805,0.03921683,-0.09813354,-0.0849683,0.02058843,-0.00054090354,-0.071283445,0.067111135,0.015219589,0.02957031,0.09460916,0.035599235,0.027275497,0.070671685,0.06093274,0.009949615,-0.02571806,-0.11281339,-0.014170156,-0.013213379,-0.0711428,-0.049716156,-0.051438116,-0.04632293,0.0076136594,0.055295896,-0.0394333,-0.085434936,-0.04496997,0.07606929,0.03420799,-0.056175176,0.05858327,-0.048137795,-0.029163364,-0.04729529,0.0044317036,0.016560528,-3.3734448e-08,0.0060270806,-0.10849122,0.060149033,0.014333168,-0.005764234,0.09795883,-0.030134821,-0.030414572,0.08348764,0.0063191936,0.009253287,0.07110926,0.060006004,-0.0050279214,-0.11017541,0.009707579,-0.064667925,0.016649516,0.03712426,0.010311418,-0.097103685,0.024500597,-0.024289425,-0.054777853,0.06779063,-0.115369104,-0.059934024,0.0992438,0.036099035,-0.01319618,0.013876292,0.025836345,0.06864424,-0.05753038,0.01919763,0.025034446,-0.009691186,-0.028872505,-0.051755987,-0.027136432,-0.03062696,-0.03395123,-0.101255134,0.008912226,0.023029972,-0.008028836,-0.015535715,0.08041527,-0.040784016,-0.011802639,0.032055855,-0.025106004,0.00163153,-0.030402374,-0.031202514,0.037302576,-0.04988728,-0.062302552,-0.031145103,0.0029622484,-0.015321086,0.036184717,0.08166743,-0.119160466 +2.1.1.196,"This enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-6B. The equivalent activity in the aerobic adenosylcobalamin biosynthesis pathway is catalysed by the bifunctional enzyme EC 2.1.1.132, precorrin-6B C5,15-methyltransferase (decarboxylating).",384,1.0,-0.041769724,0.06578037,-0.10867452,0.0004345919,0.050025553,0.046177108,-0.12766007,-0.04576904,0.040364362,0.001582937,-0.05106631,-0.04046064,-0.084873274,-0.041382816,-0.03229151,0.05032339,-0.06480657,-0.020630378,-0.045596175,-0.010909791,-0.007464884,-0.0009520197,-0.04138215,0.037929133,0.044252083,-0.038846277,0.049191937,0.006696261,-0.027996918,0.0012549963,-0.023361262,-0.0072741667,0.06116142,0.0026759242,-0.0049916315,0.14673737,-0.0043310183,-0.047267046,0.08546784,-0.009896096,-0.031232273,0.049253307,-0.022161419,0.006350039,-0.00054945314,-0.02940708,0.022048669,0.048719633,-0.0014775712,-0.025812758,0.016064117,0.005109623,-0.052102067,-0.03871124,0.043527417,0.038241047,-0.08934638,-0.07468812,0.049445488,0.00527331,0.038159497,-0.086256124,-0.032027394,0.02705226,-0.005603249,-0.02806595,0.054769143,-0.03533361,0.040754672,-0.054934785,-0.056908123,-0.07972345,-0.00863484,-0.01195106,-0.048513558,0.05090658,0.02030526,-0.04679223,0.056079086,-0.014756793,-0.03315609,0.04667733,0.00929636,0.009773273,0.06663515,-0.025138853,-0.019833818,0.010075551,0.03403573,0.095661335,-0.008230836,-0.0026901786,0.07934052,-0.012280866,-0.12154615,-0.02296895,0.058766615,0.038193952,0.015880318,-0.030565508,0.06684974,0.10007799,-0.022376273,-0.033577297,0.046526756,-0.05600097,0.036200885,0.14649452,0.028693773,0.0557628,-0.0025692962,0.08322588,-0.008006302,0.022460496,0.020679077,0.14727649,0.0071276827,-0.06748444,-0.069213465,0.04867697,0.010408417,-0.043935716,0.0069845715,0.020958172,-0.049419146,-0.08575628,-0.015095728,3.4116424e-33,0.060757402,-0.026458569,0.030593816,-0.016377332,0.009301947,0.026070321,-0.109551825,0.0552344,0.002888743,-0.007532008,-0.014542543,-0.06165471,0.04489039,0.027163722,-0.099256776,-0.081673555,-0.058872916,-0.08107329,0.0438898,0.019864377,-0.06666606,0.026986113,-0.036105506,0.011087501,-0.00920421,0.055653714,-0.02133192,0.078185916,0.0499457,0.006590857,-0.0021800064,-0.07398305,-0.07372543,-0.051583957,0.015757168,-0.012798619,-0.010049153,0.034705218,0.030305404,0.077929825,0.059737805,0.021342989,-0.06967946,-0.071547076,0.048683237,-0.034916077,-0.020405363,0.09565967,0.014289841,0.035713766,-0.019044023,0.020289369,0.098869435,-0.011973599,-0.024126811,0.034631837,-0.001932711,-0.023626776,0.011668632,0.086503685,0.06394955,-0.005311476,-0.015669618,0.064945795,-0.04669038,-0.04014087,-0.06806711,-0.06320385,0.014398924,0.036371443,-0.017576983,-0.011337916,0.052410886,0.04630417,0.02616384,0.0066606603,-0.075658076,-0.010289331,0.018797934,-0.00443771,-0.029535078,0.06939828,-0.01753095,-0.053991534,-0.06763827,0.040298484,-0.03079179,-0.057744063,0.0009858764,0.00810869,-0.027578607,-0.03238696,-0.055048376,0.021132652,0.04685362,-5.4807373e-33,0.14200193,-0.12044621,0.072932586,-0.13430747,-0.016344862,0.07391035,0.08537938,-0.102005064,-0.009358216,-0.004640209,0.09174588,0.0045823487,0.015796417,0.013428238,0.055955883,0.0055519766,-0.014657695,0.116069086,-0.0077729197,0.03480595,-0.0023007565,0.019202262,-0.03502812,0.016575214,-0.019960236,0.04882304,-0.013645,0.017132344,0.07097383,0.08444738,-0.03388983,0.037429616,-0.008675327,-0.014127663,-0.02681499,0.08018128,-0.04126504,0.009275509,-0.037664417,-0.005553377,0.027013976,0.019595327,-0.08299272,0.03567099,0.038116105,0.04872421,-0.045373805,0.04448728,-0.037096478,-0.029660601,0.058031287,0.0164773,-0.055270668,0.066090114,0.08256223,0.034988802,0.018271819,-0.05773703,0.06744442,-0.0889708,-0.09467634,-0.0073950933,0.01420922,-0.10298844,0.04786126,-0.0073225265,-0.005533206,0.06316437,0.039920613,0.017539136,0.05269333,0.06141287,-0.015645461,-0.008513366,-0.09434916,-0.0055341627,-0.004626204,-0.06241838,-0.03328415,-0.056781873,-0.07096684,-0.0042437008,0.037901867,-0.034306023,-0.098317206,-0.04643702,0.063927285,0.022007488,-0.06397918,0.07393595,-0.04763484,-0.0439146,-0.046758294,0.0048723947,0.017270625,-3.7382115e-08,-0.010279186,-0.10677138,0.06925024,-0.006412365,-0.016971271,0.11688841,-0.005578243,-0.011409727,0.048350044,-0.025677389,0.04982975,0.08132375,0.016325511,-0.016525097,-0.09684354,-0.0027391845,-0.06973918,0.01189078,0.041072786,0.014529746,-0.06671743,0.020798668,-0.010669863,-0.03705875,0.051068097,-0.09322509,-0.055555403,0.08304531,0.020810762,-0.012128289,-0.00043603126,0.030676518,0.052078504,-0.06601623,0.0018633781,-0.011891468,-0.00826953,-0.03165756,-0.04628958,-0.003444271,-0.014537818,-0.08045239,-0.100405425,0.012996831,-0.0032392717,-0.0042092125,-0.011736282,0.06447776,-0.04554143,-0.019704197,0.04953459,-0.026796255,0.011028238,0.0016374629,-0.010086534,0.039658807,-0.0719804,-0.11049629,-0.039070856,0.008059381,0.013744995,0.03722191,0.078133635,-0.12626037 +2.1.1.197,"Involved in an early step of biotin biosynthesis in Gram-negative bacteria. This enzyme catalyses the transfer of a methyl group to the omega-carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester. The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl-[acyl-carrier-protein] methyl ester [5]. While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein] [6]",384,1.0,-0.10766124,-0.021251664,-0.031503025,0.023138672,-0.00018361228,0.06839378,-0.0918507,0.043410603,0.063685216,-0.09230655,0.05800327,-0.032193266,-0.07072543,-0.0049560643,-0.028548867,-0.024567354,-0.07888399,0.053452607,-0.0032869766,-0.04277198,0.078934856,0.0058608255,-0.061972864,-0.035132427,-0.0080471635,-0.04500924,0.021036774,0.0109266145,0.05776428,-0.06149062,-0.0005586949,-0.033649374,0.02542125,-0.024123095,0.03103857,0.098305635,0.040616654,-0.06724584,0.11140828,0.0014632512,0.085389495,-0.043723196,-0.056341298,-0.01611051,-0.018688133,-0.10993345,-0.035958115,-0.03028559,0.04156019,-0.08036698,-0.0909233,0.020467367,-0.041099858,-0.020572366,0.004227605,-0.02536066,0.04288912,-0.0818858,-0.046335526,-0.022353997,0.06089635,-0.007255268,-0.03261518,-0.028460557,-0.10006654,-0.11182539,-0.0100897895,-0.02269381,0.042742908,-0.0087769525,-0.07624992,-0.093888015,-0.007473483,0.044005964,-0.04518914,0.064055696,-0.06347848,-0.03368037,-0.035824023,0.020415097,0.03284861,-0.036390256,-0.011671677,0.082926504,0.0072856937,-0.10268318,0.037091285,0.04972455,0.0024887242,0.13931935,-0.0024875996,0.012199433,0.06968313,-0.04241716,-0.03850518,0.03670482,-0.017960757,-0.048558302,0.011726597,-0.028326102,-0.0033339236,0.02170881,-0.047585323,-0.06862035,-0.056054406,-0.033323947,-0.029142663,0.098932564,0.05987226,-0.020052755,-0.023073291,0.049858544,-0.0048051714,-0.047743358,-0.10847964,0.095914476,-0.027228767,-0.06770592,-0.024390271,-0.02330901,-0.048601903,-0.015530736,0.039272297,0.035674192,0.026514452,-0.02359937,-0.103682004,5.4297256e-36,0.068277024,-0.012444669,-0.011879693,-0.03479639,-0.025399916,-0.01830241,-0.10592407,0.0027061787,0.025221406,-0.0235341,-0.017937249,-0.09725163,-0.01995736,0.03411048,0.00984791,-0.014117879,0.0044094566,-0.03453682,0.056208182,0.03708955,0.016857633,0.04683399,-0.008362669,-0.046501916,0.043505207,0.034045566,-0.012925277,-0.011702744,0.015765758,0.0036890523,-0.038074248,-0.0640529,-0.034808237,0.03683354,0.15147501,0.013561266,0.023567434,0.008122053,0.038406525,0.094739035,0.07878144,0.009792042,0.0056278445,-0.05853501,0.056033242,0.083736144,-0.037999265,0.08495961,0.06574583,0.10105051,0.03576863,-0.041611176,-0.0065589724,0.03862906,-0.05838439,0.033282977,-0.08148773,0.007924015,-0.042712886,-0.00019983141,0.057776056,0.0016454274,-0.003515868,-0.0061999992,0.028979832,-0.028426155,-0.04084034,-0.02758244,-0.03296234,0.10144264,-0.025030855,0.024146963,0.068141915,0.01937845,0.064446166,-0.018921234,-0.10737332,0.038948786,0.019076807,0.037254754,0.008614265,0.043462105,0.021578161,-0.056050874,-0.08921499,0.04364336,-0.03335398,0.046513796,0.059780993,-0.008967945,0.047742847,-0.08230663,-0.03553488,0.101065084,-0.08596372,-4.0160405e-33,0.09623561,-0.111365296,0.09560551,-0.10011543,-0.04170827,0.034980107,0.03986389,0.057091583,-0.023689449,0.043104623,0.056032166,0.04500613,0.04515329,0.027826926,-0.006474383,0.041086406,-0.041584153,0.015042157,-0.017170247,-0.0021713858,-0.046724137,0.035291843,-0.011308408,0.12337538,0.04059928,0.04093593,-0.010953522,0.10389637,-0.016194325,0.005193147,0.039598864,0.027887693,-0.016258076,-0.059714742,-0.012198799,0.05724499,-0.06443563,0.038545065,0.011104949,0.026790537,0.013493268,-0.014882757,0.0052751303,0.012068174,0.07057291,-0.060101107,-0.04023097,-0.06037809,0.040999737,-0.047239214,0.037415504,0.02740164,0.05394108,-0.0059485384,-0.02803282,0.060095068,0.012769914,0.03611818,0.05035916,0.008621106,-0.019785713,-0.08514952,0.023843622,-0.020604385,-0.03706259,0.086434074,0.018312518,-0.014926886,0.021939564,-0.026096636,0.0352431,0.052351385,0.019043624,0.06705194,0.009581213,-0.03546951,-0.028612383,-0.06285701,-0.05262057,0.009249275,-0.029103387,0.007982472,-0.0699568,-0.12949231,-0.09440411,0.009846893,0.02531918,0.043539226,-0.04892721,0.02506008,-0.032150466,0.0130475825,-0.021760412,0.049432416,0.013588266,-4.5790777e-08,0.008300017,-0.09440407,0.03609262,0.0058263284,-0.04026081,0.04323172,-0.051268402,-0.056032997,0.04417774,-0.029011188,-0.024874687,0.050787225,-0.074411884,0.08208668,-0.025953498,0.023401495,-0.071187705,0.022509344,0.039501183,-0.04890597,-0.08835461,0.018383633,-0.07238397,0.02891529,0.029917073,-0.03888658,-0.0031281912,0.049246613,0.055359036,-0.018780833,0.029720115,0.08135288,0.00343256,0.031290196,-0.049767964,-0.009942537,-0.053196248,-0.075949706,0.010599549,0.08035203,0.08677783,0.024652557,-0.08434934,-0.0010671508,0.049062494,0.005519397,-0.0038672367,0.05803604,-0.0066704885,0.016281197,0.07462471,0.024136873,-0.059730314,-0.030714164,-0.036565952,-0.032893907,-0.053855855,-0.07170632,-0.04825115,0.00562906,-0.009051898,-0.06555898,0.1424916,-0.017948817 +2.1.1.198,RsmI catalyses the 2'-O-methylation of cytidine1402 and RsmH (EC 2.1.1.199) catalyses the N4-methylation of cytidine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons. ,384,1.0,-0.03612368,0.039666556,-0.11401499,-0.054193452,0.015704079,0.056852255,-0.055162914,0.026039068,-0.015514111,-0.027869003,0.05844826,-0.029688274,-0.017321851,0.09977764,0.0026345258,-0.0012201335,-0.073032945,0.047435384,-0.004551693,-0.023288593,0.034567446,0.022278676,-0.051129423,-0.021397684,-0.0009962093,0.06738116,0.031197878,-0.0005931125,0.04785837,-0.02105636,0.04974685,0.0015590139,0.058272928,-0.06552911,0.06106438,0.030778334,0.020145286,-0.08736758,0.032389585,0.009087968,0.0021150385,0.071036555,0.013486667,0.008161077,0.05003426,-0.0063933255,0.08772595,-0.010123988,0.007327031,-0.09173105,0.0029199882,-0.005236885,-0.016371489,0.04140745,0.09329001,0.027442465,-0.09328521,-0.04534333,-0.019881196,-0.02948241,0.010839787,-0.04277839,-0.05202809,-0.026652582,-0.03652255,0.009843302,0.064450756,-0.029117651,0.008615212,-0.015843935,-0.030310841,-0.072685055,-0.10378614,0.0635553,-0.026607307,0.023543883,0.06393649,-0.06708207,0.028045041,-0.01501564,0.013107743,-0.061090168,0.0056772204,-0.030674955,0.018570539,0.05972127,0.05463888,-0.0093485415,0.036164556,0.055352364,0.0615433,-0.019764317,0.031310223,-0.02772933,-0.065679915,0.0060282983,-0.0040902006,0.034456786,0.047953654,-0.0025116722,0.060479,0.14435582,-0.12528001,-0.05901914,-0.015357758,0.019395398,0.053206343,0.057823375,-0.040821508,0.006286201,0.025874868,0.034644045,-0.0142532345,0.02964502,-0.044882227,0.06735155,0.022631368,-0.008225301,-0.053177405,-0.027306687,-0.052470576,-0.023493541,-0.019166036,0.05851748,-0.016818307,-0.0298279,-0.1394639,2.7611066e-33,0.03516955,0.08697026,0.006922659,-0.016761824,0.0254097,-0.0059570167,-0.021650678,-0.014529015,0.03576518,-0.083840676,-0.057231393,-0.05379877,0.050589785,0.040931072,-0.10669827,-0.106412075,0.012309035,-0.0045129424,0.017889801,0.016309587,-0.029236825,0.08383682,0.06330888,-0.08113833,0.0026103414,0.047800373,0.015284986,-0.061598077,0.077451356,-0.0016787777,-0.0750248,-0.062327765,-0.11708584,0.03999364,0.0030433144,-0.038381148,-0.00012163812,-0.07046295,0.0762148,0.046044197,0.0045556095,0.04568993,-0.03196081,-0.008016649,-0.0055364203,0.00046902546,-0.031162608,0.060779713,-0.02022877,0.051994298,0.0008216782,0.018776186,-0.004613369,-0.028638633,-0.026813488,-0.027050335,-0.017779868,-0.05377235,0.0050110808,0.024292435,0.011983408,-0.03305992,-0.023143481,0.022662941,0.07393156,0.02925886,-0.061438363,-0.09826367,0.0013409521,0.075999446,-0.017032957,-0.007791331,0.12312999,0.008556385,0.064703114,-0.02422862,-0.03507654,0.006962502,0.100269556,0.06697413,-0.07307368,0.11778056,-0.024164071,-0.015782477,-0.020125339,-0.03818488,0.08481356,-0.048095174,-0.005151689,0.09748623,-0.0072784545,-0.05007375,0.0118869515,0.0036668552,0.0386671,-3.935232e-33,0.071030475,-0.05215669,-0.008855399,-0.055888526,-0.08868177,-0.047824424,0.049096603,-0.040336207,0.028908236,-0.04308665,0.09093993,-0.011400262,0.055597138,0.0004835788,0.040503513,-0.07552982,0.045070957,0.07669972,-0.005071797,-0.029477961,0.009125843,0.012655787,-0.025302762,0.099179484,0.07964534,-0.012930106,0.026117507,0.030343525,0.008444059,0.009566134,0.025250956,-0.019222643,-0.028515235,-0.01332791,-0.043859996,0.1454141,0.026080823,0.065980725,0.014365256,0.0318622,-0.0039503085,0.06447867,-0.021788856,0.083707884,-0.030124888,0.04363123,-0.03859063,0.043751016,-0.03286123,-0.06361288,0.064108595,-0.025508558,-0.039084163,-0.012831971,0.045541808,0.0021916165,-0.04916217,-0.012423602,0.015401347,-0.08694037,-0.0050836583,-0.07926828,-0.058492187,-0.034278966,-0.021968827,0.010418019,-5.4806205e-05,-0.09629431,0.015250825,-0.019482568,0.028510293,-0.048108898,0.03102244,0.0020948686,-0.04193979,-0.04628787,-0.1008501,-0.10252697,-0.0195696,-0.09832571,-0.03490626,-0.022695633,-0.011460771,-0.00028381209,-0.029612917,-0.061906084,0.08148677,0.08187563,-0.012346468,-0.03400736,-0.01624968,0.00034260476,0.015268335,0.12543108,0.027500398,-3.3825e-08,0.017660014,-0.1090517,0.0010348737,0.014473443,-0.048752904,0.097823925,-0.068072475,-0.02319044,0.055717237,-0.062841006,0.07840371,-0.00056968216,-0.027992483,-0.011800811,0.012065098,0.07495801,-0.057433892,0.016770408,0.005485104,-0.02339944,-0.06596345,0.09269449,-0.09641637,-0.024125207,-0.018167743,0.01187519,0.021590125,0.06980735,0.017269839,-0.1260509,0.14088784,-0.03672624,0.04287714,0.022327024,-0.016184641,-0.043599784,0.062933356,-0.0010177201,0.091745116,-0.021074425,0.008964663,-0.031729072,-0.12854053,0.06646079,-0.051517546,-0.011820765,-0.055110216,0.028356215,-0.07872296,-0.0029553457,0.08701007,-0.03339148,0.043848995,-0.05507505,-0.006491364,0.011801374,-0.08999589,-0.015494105,0.016424732,0.03137711,0.040216286,0.038296252,0.05000566,-0.044326454 +2.1.1.199,RsmH catalyses the N4-methylation of cytosine1402 and RsmI (EC 2.1.1.198) catalyses the 2'-O-methylation of cytosine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons. ,384,1.0,-0.01541548,0.029025361,-0.087557375,-0.02323322,0.016550485,0.058333535,-0.04672743,0.00023559338,-0.009924067,0.0027538373,0.044565763,-0.0009811715,-0.023971878,0.08784483,0.00097293325,0.033915468,-0.051810075,0.043767534,0.004571682,-0.029886717,0.06289081,0.0122732725,-0.031489495,-0.021078046,0.0015994112,0.07484863,0.04672699,0.017765757,0.05243063,-0.042621963,0.04776835,0.023197211,0.0364988,-0.03485761,0.031227412,0.05112176,0.042009726,-0.09448997,0.010545974,-0.017049426,0.029316178,0.053911183,0.032382537,-0.007675646,0.043372065,-0.0078249015,0.07485317,-0.025012678,0.020152887,-0.103388116,-0.00935959,-0.026893638,-0.019949129,0.05402211,0.08202256,0.030722858,-0.081252754,-0.042570822,-0.013392591,-0.0292423,0.011341793,-0.057183795,-0.07358996,-0.022268375,-0.008952097,0.0072898814,0.08086999,-0.022429291,-0.020713236,0.014418713,-0.011728368,-0.04646857,-0.09329613,0.044246774,-0.03753328,0.038323104,0.06882284,-0.08123212,0.030570965,-0.03376846,0.043092676,-0.024060555,0.034552615,-0.023769453,-0.0052397344,0.07290439,0.06256197,-0.0030157939,0.032579746,0.064149305,0.0391011,-0.032434102,0.033920474,0.004444796,-0.09002965,0.0071783313,0.00849474,0.03409669,0.057743896,-0.02513871,0.061898604,0.16448118,-0.10151744,-0.08220325,-0.0029890353,0.047001343,0.025909392,0.07462061,-0.009613338,0.016018834,0.03586375,0.054583523,-0.0072063776,0.06542791,-0.06701229,0.04012704,0.017748319,-0.017258456,-0.059985306,-0.025459109,-0.06997033,0.0046903896,-0.023190849,0.041991085,-0.034518477,-0.043955535,-0.15447508,3.6045216e-33,0.047518637,0.06788559,0.009825528,-0.011266437,0.034627944,-0.012896536,-0.005198078,-0.028013522,0.012988174,-0.06967155,-0.059800312,-0.04980831,0.05521311,0.04675836,-0.078567944,-0.089467674,-0.0041796546,-0.018713262,0.017463561,0.025007606,-0.06261124,0.056056328,0.009306888,-0.07911667,-0.007981478,0.062440183,0.025124386,-0.04649218,0.07717567,-0.00794632,-0.052799903,-0.033158258,-0.10887446,0.049414843,0.02055484,-0.02992499,0.016705343,-0.050793827,0.07443993,0.02620117,0.018800346,0.025636224,-0.03380455,-0.000436212,-0.026673244,-0.021086678,-0.045042884,0.05824647,0.0007119311,0.07587361,0.0011889136,0.031046651,0.0021267626,-0.031219264,-0.028988935,-0.038726278,-0.028043298,-0.047461852,0.011779259,0.014129645,0.006679429,-0.05263894,-0.028325839,0.04099954,0.06530928,0.026046889,-0.05833299,-0.10433808,-0.012571333,0.07931113,-0.00018322202,-0.015757209,0.12663612,0.005260504,0.05761548,-0.0386845,-0.0134275155,-0.025899014,0.10202104,0.07867758,-0.05821195,0.112248786,-0.04420621,-0.03255219,-0.01891993,-0.02132632,0.07994341,-0.044165753,-0.0063482528,0.10937855,-0.0031198985,-0.061858248,0.0025494914,0.0042548915,0.011710222,-4.51927e-33,0.07459002,-0.029329207,-0.020953475,-0.02869096,-0.0964163,-0.060208336,0.067186184,-0.012728392,0.0048221373,-0.062628545,0.11748283,-0.012226775,0.068691574,-0.0012291163,0.06905331,-0.087561525,0.013095856,0.061888367,0.0047771875,-0.0070939683,0.0077747526,0.03995828,-0.060982514,0.13412015,0.081009135,-0.016460374,0.00908682,0.03492407,0.0071818535,0.035103112,0.04662531,-0.025437081,-0.046875082,0.008915962,-0.06379271,0.14287855,0.02502393,0.06174508,0.017768675,0.041306876,-0.023922946,0.07128791,-0.027381923,0.081341565,-0.021083172,0.06492621,-0.056493074,0.048196252,-0.029066132,-0.07021041,0.04773726,-0.015950665,-0.032753196,-0.009607707,0.033393756,-0.010050031,-0.070356034,-0.022998495,0.026287213,-0.10203388,-0.012738757,-0.08724191,-0.03540287,-0.03253983,-0.035705574,0.028558621,0.0021434647,-0.08827009,0.0060827583,-0.031285916,0.033367667,-0.021051206,0.023876546,0.009999416,-0.022869214,-0.06451225,-0.110796876,-0.08217192,-0.038402323,-0.097706296,-0.0027004646,0.0127301905,-0.010204613,-0.025812654,-0.03231896,-0.06226564,0.09535522,0.089878686,-0.030708525,-0.017306203,-0.0055218297,0.0078418115,-0.011559666,0.118259534,0.037840813,-3.530063e-08,0.0061888094,-0.109097734,0.003864984,-0.011289339,-0.033207268,0.08900838,-0.060229234,-0.0048489394,0.074104905,-0.056065574,0.06477607,-0.014418948,-0.044213995,0.014936207,0.009094658,0.05555396,-0.027856134,0.021850588,0.0015734729,-0.025763333,-0.08211962,0.08004507,-0.08155372,-0.0020905745,0.00043048052,0.020628482,0.011446198,0.060304128,-0.0028533055,-0.12383467,0.11416389,-0.025945675,0.04244988,0.011445773,-0.031162255,-0.041905355,0.06437728,0.010432827,0.081992686,-0.02284919,0.022497972,-0.04871294,-0.0998534,0.054675613,-0.08212344,-0.0375262,-0.044785433,0.0056493036,-0.07119074,-0.016592309,0.08383853,-0.044023115,0.027338255,-0.07699644,-0.030404706,0.003376496,-0.08303044,-0.0010252944,0.00692191,0.0098498445,0.039580185,0.044901885,0.019740218,-0.0708626 +2.3.1.192,"Not identical with EC 2.3.1.13 (glycine N-acyltransferase). +This enzyme was purified from bovine liver mitochondria. L-asparagine, L-glutamine and L-arginine are alternative substrates to glycine, but have higher Km values. ",384,1.0,-0.054566607,-0.046349898,-0.1332819,-0.020857623,0.01887299,0.048086632,-0.121680826,0.05502316,0.027667405,-0.07332621,0.11951104,0.006361166,-0.02275841,0.00091250957,-0.073152855,-0.021742428,0.0048918137,-0.064968266,-0.052793857,-0.091095306,-0.025779799,0.042720888,-0.01792651,-0.046521477,0.07482685,-0.0939623,0.0016918689,-0.045577493,0.020993697,-0.06919031,-0.014295461,-0.090037555,-0.004210137,-0.05277977,0.06702834,0.016832178,-0.030103832,-0.04372083,0.047003,0.006919998,0.018754354,0.012707995,-0.023384297,-0.023317304,-0.023643536,-0.04274744,0.03786956,-0.011029242,0.033389118,0.04310511,0.041055042,-0.0025489382,-0.015181943,-0.005349934,0.00996503,-0.0019672215,-0.17128393,-0.04673678,-0.02595599,0.037424695,-0.03614938,0.05678386,0.008343684,-0.022020023,0.008973255,-0.053442765,0.10915182,-0.114648834,0.01838552,-0.04791722,-0.016067056,-0.1190083,-0.0021885464,0.018571567,-0.024659302,0.019143328,-0.07266352,0.01890543,0.05523159,-0.0009905067,-0.0046362225,-0.06482246,0.006428484,0.04962778,-0.036558487,-0.047013003,-0.023065526,0.07944318,-0.057121966,0.02181472,0.06964196,-0.056491714,0.03568309,0.00749338,-0.0344659,0.038916763,0.04375166,0.07893491,-0.02803229,-0.010992588,-0.013159529,0.13965866,-0.022651413,-0.04076443,-0.03518115,0.020220742,0.015351923,0.059337813,0.036671262,-0.008944185,0.010048942,-0.00265245,0.0030417535,-0.009382249,-0.022221643,0.13555814,0.0025253242,-0.05230847,0.006951386,0.021514433,0.053626906,0.027695194,0.065314285,0.10829994,0.052248213,0.10940289,0.0019324035,2.5085791e-33,0.08847253,0.020652633,0.041355096,-0.037495658,-0.028664704,0.0101445215,-0.14503703,0.0456853,0.05451745,-0.093479335,-0.056833874,-0.022357143,0.022387289,0.002687547,0.0061790594,-0.0057978146,-0.006273783,-0.067311905,0.08055394,0.005562195,0.026416337,-0.009619096,0.051097732,-0.014037615,0.05406401,0.002238301,0.032347597,0.04872274,0.038830042,0.025432378,-0.031494875,-0.1759139,-0.034992836,0.01371144,-0.02592589,0.004014577,-0.039577316,-0.07735934,0.0579129,0.073144235,0.044059962,0.008198618,0.060315445,-0.062187742,0.054955337,0.02124647,-0.06568647,0.016231738,-0.046181045,0.04591981,0.028553983,-0.035893004,0.09290051,-0.019172717,0.011655928,0.022326354,-0.021700468,0.03156703,0.016224489,0.09239714,0.04169194,0.06943664,0.026927115,0.035427555,0.015496867,0.033088136,-0.112247735,-0.007122836,-0.065269694,0.051028118,-0.05448535,-0.046878316,0.11560877,-0.005112686,0.04698309,-0.055749014,-0.046550523,0.066217005,-0.0319793,-0.047381755,-0.053593464,0.060652267,-0.00018536058,0.002251533,-0.01981922,-0.03988486,0.00037321355,-0.04690947,0.070131905,-0.019322524,-0.004237027,0.026569923,-0.07495022,-0.011223768,-0.005208605,-3.0548742e-33,0.05299405,-0.07384007,0.029537786,-0.050100155,-0.04293605,0.026219653,0.032090925,0.032028567,0.060720004,0.006097721,0.029355928,0.033600453,-0.012368998,-0.10468058,0.081102446,-0.0034547618,0.006662724,0.052922234,0.0123711135,-0.030175263,-0.03087924,-0.00032408387,-0.025998175,0.017282262,0.02426231,0.008796576,-0.032560993,0.04543441,0.05052478,0.013075696,-0.03053675,0.039476182,-0.0058598826,-0.048553877,-0.037590165,0.010550382,0.015765062,-0.001882803,-0.04863971,-0.026130289,0.045806855,0.08464909,-0.025742834,0.043566246,0.054039195,0.110915616,-0.050658774,-0.06924853,0.0051929923,-0.105368204,0.013796705,-0.0072498177,0.02504837,0.025745198,0.028729914,0.065119125,0.051996887,0.047476947,0.041447368,0.0060321577,0.0037457752,-0.03375782,0.0020698893,-0.024205705,0.031703442,0.014389853,-0.038510736,0.03760051,-0.027890464,0.08952908,0.018829664,-0.061205022,-0.012421441,0.07266144,-0.0015915893,0.013893696,-0.014702014,-0.025783304,0.006614669,-0.08181967,-0.007897647,-0.029130012,-0.034680925,0.022581952,0.01902359,-0.027958322,0.0027220738,0.14238049,0.021199325,0.031990986,-0.021388015,-0.052061327,-0.115374,0.053133346,0.016073281,-3.407429e-08,0.06744488,-0.058899835,0.032315593,-0.008479783,-0.0057569477,0.08654551,-0.025771104,0.037274893,0.0044289413,-0.034508895,-0.038111635,0.022267316,-0.04140864,-0.0384555,-0.042718627,0.094500445,-0.04724291,0.026543416,0.018847298,0.071713336,-0.064987056,0.055913102,-0.059466805,0.0038510861,-0.017894391,-0.013682753,-0.023925092,0.07656115,-0.028110996,-0.082254894,0.01594779,0.022051169,0.04238879,-0.050751787,-0.088089675,-0.05553308,0.025299847,-0.04416054,0.024856424,0.056917444,-0.05314201,-0.0038686404,-0.052048653,-0.014809598,0.050814737,-0.04412044,0.060384773,-0.005370095,-0.03151328,0.029385222,-0.019844435,-0.052484844,0.014438191,-0.10615569,-0.043198243,-0.060401544,-0.1033118,-0.111155525,0.017150382,-0.048067957,0.038217183,0.011107195,0.15838031,0.04911667 +2.5.1.93,The enzyme is involved in shikonin biosynthesis. It has a strict substrate specificity for geranyl diphosphate and an absolute requirement for Mg2+ [2]. ,384,1.0,-0.0537576,-0.038278658,-0.06483425,-0.032486416,0.05849531,-0.06781139,-0.057148267,0.010161403,0.008690997,-0.052457113,0.06852192,-0.015852751,0.025067305,0.033091467,-0.0036721285,-0.021550134,-0.034946933,0.07451607,-0.021263815,-0.035795767,0.11890715,-0.035430003,0.024259407,0.01082594,0.005017155,-0.02927168,0.095747165,0.025628205,0.0321182,0.0073769656,-0.017918153,0.05576663,0.001990924,-0.0729508,-0.010665153,0.18235669,-0.03913889,-0.016629182,-0.033835646,-0.011751442,0.03873358,-0.027648138,0.08625679,-0.09802725,-0.014000047,-0.05351662,-0.006215701,-0.06949379,0.05273368,-0.033039413,-0.1293476,-0.019309528,0.02923558,-0.06029826,0.072007,-0.08556892,-0.06372104,-0.061753854,-0.06361304,-0.00641132,-0.011926035,0.0063400976,-0.08060875,-0.044208456,-0.010814201,-0.038587153,-0.003729012,-0.05017147,0.029201457,-0.0025001762,-0.039726447,-0.053502705,0.008033633,-0.029209575,-0.029532682,0.043738328,0.007855701,-0.012611592,0.021705221,-0.050436273,0.05600913,-0.008050279,0.09493894,0.057586625,0.013325264,0.017557437,0.06305863,0.057584472,-0.0110941455,0.112993345,0.10850154,0.01937522,0.0036250292,-0.018491883,-0.014507305,0.07728729,0.0043411413,0.026162108,0.00471125,0.0042526964,0.04541407,0.06282168,-0.014523192,-0.024240801,-0.03950023,-0.01931519,-0.03230658,0.0897885,0.04617616,-0.022792753,0.05889674,-0.032846436,0.014270558,-0.0041497145,-0.049675483,0.10682164,0.0038168125,-0.034801003,-0.03870611,0.06918076,0.016239123,0.08587399,0.001818563,0.11092732,0.013690482,0.0074158977,-0.091038905,3.0791202e-34,0.062748864,0.061801426,0.029348662,-0.038078655,-0.117036305,-0.026129942,-0.10864753,-0.06829471,-0.017173236,-0.033303656,-0.06347262,-0.05158603,-0.042208456,-0.009332176,-0.0038758891,-0.06666793,-0.0016166863,-0.0438787,0.11975678,0.0701292,-0.010989378,0.046679247,-0.07428751,-0.042627487,0.017284567,0.08444557,-0.0037185496,-0.06546036,0.0029682154,0.022610078,0.02401916,-0.073697954,-0.06660165,0.06362099,0.027712625,-0.053397067,-0.00813446,-0.056191426,-0.009035709,0.009170861,0.030100148,0.0061795013,0.017709648,0.020218655,0.026204508,-0.060531393,-0.022643115,0.051441997,0.0582945,0.08888741,0.06678928,0.031010399,0.10338524,-0.025247797,-0.10990685,-0.06770148,0.005689155,-0.03189791,0.04946777,0.05362754,-0.014661582,-0.011768211,0.0051734746,0.029774608,0.04231899,-0.020952266,-0.04297647,-0.048559323,-0.022804892,0.13226119,-0.018897876,-0.059465565,0.044237163,0.08285472,0.013497674,-0.008304632,0.014379063,-0.016331239,0.03827371,0.056842666,-0.010686179,0.030714521,-0.06427765,-0.032588832,-0.101291716,0.0224485,-0.036918208,-0.04586388,-0.045960594,0.00674297,-0.023011193,0.011646635,-0.04556072,0.04682758,0.0027186926,-2.5652764e-33,0.051423352,-0.045493517,0.005385284,-0.04034983,-0.12140574,0.024902433,0.042831667,-0.033164565,0.053099595,0.03552619,0.0850359,-0.07543374,0.047403786,-0.032625955,-0.046344835,0.04703638,-0.059572306,0.11518506,0.0030948096,-0.017224945,-0.06493388,0.10461622,0.046803396,0.06978481,0.069805436,0.036663342,-0.007927435,0.023542756,-0.0057838387,0.101827145,0.0052911155,-0.012973745,-0.09062691,-0.020701572,-0.047919724,0.042055413,-0.014864374,0.007652125,0.016755506,0.037252404,0.00633117,0.044202182,0.09771564,0.084471375,0.0249233,0.029159,0.009112425,0.082862385,0.06994013,-0.13033207,-0.06605149,0.0723312,0.05038448,0.017950365,-0.004906039,0.025983084,0.015512215,-0.0159477,-0.0024980672,-0.030518847,-0.036043316,-0.04748774,-0.017780725,-0.017461892,-0.005497804,0.104310304,0.0022554577,-0.025903324,0.04498461,-0.035782497,0.047053486,-0.007786304,0.05993004,0.04054189,-0.030161228,0.03810369,-0.015840832,-0.024389684,0.005610465,-0.062749825,0.065379374,0.06884481,-0.0497223,-0.07248098,-0.036823127,-0.103936724,0.043155126,0.04326485,-0.00023111598,-0.060365975,0.00016115735,0.0027929782,-0.05093564,0.025527846,-0.0036849633,-2.822263e-08,0.0016086934,-0.09751417,0.021987999,-0.08660393,0.015231865,0.06821035,-0.04477146,-0.07262753,0.01760663,0.03583466,-0.017021075,0.039657257,-0.07816212,-0.008125685,0.026174854,0.041976154,0.015749017,0.058165107,-0.0044495156,-0.04153134,-0.011996477,-0.089088,-0.10790803,0.0178853,-0.026686868,-0.04020729,-0.024523504,0.083611086,0.009244871,-0.058742892,0.017448064,-0.01170522,-0.05477273,0.0023710742,-0.022865586,0.039503977,-0.08407559,-0.0442065,0.008828895,-0.034616854,-0.03196698,-0.05710556,0.0015705399,-0.004546082,-0.05925481,-0.006115856,0.019192867,0.00034789983,0.010197729,0.051270146,0.05246696,-0.01630535,0.041203324,-0.038271785,-0.04522098,0.014860095,0.04903987,-0.061059475,0.018168176,-0.09333495,0.030086305,0.06335537,0.08696087,-0.041442145 +2.8.2.35,"The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) [1].",384,1.0,-0.036401212,-0.09078255,-0.035655033,-0.071014434,-0.02624903,0.020906538,0.02638267,0.052000597,0.017867114,0.02074216,0.039513666,-0.0027026662,-0.059556507,0.03663533,-0.118936226,0.032281112,-0.026210321,0.0073552695,-0.015216989,0.030891346,0.08071461,-0.060763158,-0.061447937,-0.022776732,0.0033897765,0.05881705,0.03472541,0.011774453,-0.03428512,-0.10784634,-0.0408285,-0.030330665,-0.0049457685,-0.0366905,-0.060506474,0.027788132,-0.007512226,-0.01418753,0.06737893,-0.026355783,0.01895884,0.018344576,-0.019242365,-0.04819276,-0.0057370346,-0.079017244,-0.046737246,0.075857475,0.07376344,-0.036094587,0.052832443,-0.041903265,-0.05821739,0.092009366,0.01236292,-0.003943846,-0.04585743,-0.026487987,0.04791976,0.037685048,0.062074408,0.090637386,-0.002737718,-0.07237703,0.0079891635,-0.090753496,0.08147428,-0.059760388,-0.058378164,0.056687813,-0.079497606,0.03807919,-0.025011547,0.011168194,0.018264677,0.054690074,-0.010306708,-0.049105033,-0.014661097,-0.048846286,0.025058275,0.08935216,0.0590645,0.069032885,-0.021867843,-0.019838843,0.009201127,-0.02136376,0.0608681,-0.028263865,0.047360834,-0.0137792155,-0.057649557,-0.035177663,-0.030000148,0.0152042685,-0.029621992,0.12150359,0.07513748,0.015704386,0.024085982,-0.0596343,-0.09263844,-0.09396553,-0.071813196,0.06229149,0.0196367,0.033683393,0.009475351,0.04177372,-0.04588428,-0.02239823,0.0021028826,0.045815215,-0.14870438,0.11375304,-0.0024530739,-0.06018494,-0.1187728,-0.035775367,-0.008594289,-0.025886973,0.066446595,0.0058703194,0.023780607,0.03689887,-0.04362607,3.531599e-33,0.12857626,0.05761631,0.10638749,-0.015233465,-0.015060418,-0.03982911,-0.04581003,-0.00097067066,0.032214843,-0.03324031,-0.11388854,0.01545686,-0.007987704,0.009467075,-0.09871546,0.08052339,0.040478,-0.013679767,0.018641522,-0.022054087,-0.01537631,0.060125627,-0.03776979,-0.082871,0.019692656,0.034750536,-0.0017438077,0.027268333,0.07433582,0.013576238,0.0049655708,-0.07348771,-0.007479055,0.02074392,0.052466687,0.040196415,0.0031609838,-0.046693824,0.05429832,-0.0709384,0.07559789,-0.0019949244,0.04257533,-0.0017799744,-0.0077918475,0.00960111,-0.052067786,-0.016233457,-0.0011289848,0.0790645,0.005338159,-0.05282958,0.010851553,0.011849264,-0.04452307,-0.009730506,-0.079760246,-0.069845825,0.05847998,0.076120175,0.012797185,0.043049626,-0.019881556,-0.055611104,0.028750118,0.022686685,-0.072154336,0.061535183,-0.011512225,-0.015848262,-0.0606527,-0.091100454,0.0044476734,0.08024473,0.0112455925,-0.0027035382,0.064519994,0.06361825,0.0082277525,-0.0018863494,-0.06897958,0.029664818,-0.07756005,-0.04508623,-0.080340646,0.043334067,0.0007755048,-0.04813484,-0.01988813,-0.0025486539,0.016021198,-0.019842077,-0.07286515,-0.00031509355,-0.014074307,-7.0321966e-33,0.060037863,-0.06633147,0.030438017,-0.03337079,-0.043116655,0.015467889,0.078335024,0.023029406,0.04326136,0.015187868,0.038012065,0.030061452,-0.01157357,-0.048506767,0.038694758,0.024080964,0.031038247,-0.018627804,-0.060745154,-0.029176911,-0.009068204,0.10471464,-0.022809485,0.014921364,-0.028579546,-0.045708597,0.06814969,-0.013774418,-0.007828362,0.09778899,0.026932228,-0.059542086,-0.06526695,-0.046902943,-0.048999343,-0.045160227,-0.030409854,-0.031237295,-0.012129098,0.061147057,-0.024022602,-0.04524026,0.036443032,0.13133854,0.08549729,0.05039429,-0.06896235,0.044318333,0.050078284,-0.02040241,0.06147178,-0.02064957,0.040358707,-0.013860529,0.045695476,0.05754535,0.05958587,0.04757483,-0.01912013,0.038552806,-0.01999487,-0.010196674,-0.005884166,-0.12320743,-0.008451299,0.037284747,-0.03344742,-0.07379576,0.02716006,-0.060804464,-0.027818741,-0.02994664,-0.025492797,-0.015490409,-0.045086514,-0.060595077,-0.09292377,-0.03481012,-0.04739838,0.019231165,-0.022595562,0.057560883,0.018849049,-0.09132884,0.01375312,0.009708375,0.06503533,0.07708316,-0.031126596,-0.04958739,-0.023437174,-0.007003519,-0.012638931,0.022583857,-0.02137582,-5.0463626e-08,0.047819853,0.01584764,0.08072135,-0.011348733,-0.1347153,0.045276925,-0.008826607,0.049177594,0.032540992,-0.00511536,-0.0075556017,0.18005012,0.026341798,0.032691434,0.024695268,0.020394763,0.0081306845,0.0037918568,-0.048296172,-0.05284781,-0.05949269,-0.014433004,-0.088114545,-0.02080546,0.022899544,-0.07547814,0.117785364,-0.01932646,-0.100819804,-0.06402722,0.11056676,0.050694596,-0.03681722,-0.057037186,0.056599464,0.044218503,-0.022080414,0.005039527,0.06202314,0.010124466,0.028002976,0.025836345,-0.052631952,0.007634518,-0.025710454,-0.0024042283,0.00030884566,0.06952168,-0.062474567,0.04931569,0.032934472,-0.03879187,-0.05540085,-0.10454053,-0.0081894435,-0.059550073,0.009576215,-0.043655135,0.025860013,0.019937815,0.022001194,-0.06379492,0.07388056,0.047400106 +3.1.2.28,"This enzyme participates in the synthesis of menaquinones [4], phylloquinone [3], as well as several plant pigments [1,2]. The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 does not accept benzoyl-CoA or phenylacetyl-CoA as substrates [3].",384,1.0,-0.11321074,-0.024707068,-0.102850206,-0.0021805363,-0.020259729,0.10515309,-0.07508928,-0.021520197,0.009923365,0.019645525,-0.0011107271,-0.06119319,-0.069250554,0.007718151,-0.07892268,0.08933382,-0.09111542,0.036656532,0.04237417,0.063290186,0.01239669,-0.0116599435,-0.059770778,-0.022759955,0.042563926,-0.010443288,-0.012318701,0.06533851,-0.041025057,0.038927376,0.01847343,-0.032306526,0.054506022,-0.023962777,0.06960905,0.040368833,-0.028236058,-0.13141358,0.05216249,0.08451508,0.051576845,-0.020177854,-0.06023429,0.04878819,0.01438739,0.054248884,0.054159597,-0.0027016741,0.058965787,-0.074102804,-0.03189458,-0.026128909,-0.047247205,0.012831861,-0.034193154,0.047078587,-0.060933247,0.016988955,0.044116817,0.049506262,0.030000305,-0.016443735,0.017825356,0.021194013,0.053916626,-0.023127383,-0.12941203,-0.019222314,0.06873124,-0.0067192754,-0.01255688,-0.07253291,-0.044589248,0.0020391073,-0.07089171,0.07904606,0.0038129939,-0.017590033,-0.03385859,-0.094216235,-0.0018722662,-0.03433144,-0.06998192,0.114377975,0.02913839,-0.011983695,-0.0040111174,0.038192976,0.0051837084,0.040213052,0.080149725,0.0150741385,-0.0102836145,-0.13126162,-0.0609588,0.05513677,0.06546493,0.03146916,-0.010479648,-0.02654559,0.023576524,0.0058053853,0.00732484,-0.1525661,-0.03157855,0.03728582,-0.017056068,0.08890015,0.043468293,-0.0014068856,-0.09911601,0.034663077,-0.0989504,-0.04006832,0.012613992,0.018661173,0.044185426,-0.010787357,-0.08103035,0.087298326,-0.010139899,-0.050015576,0.06276622,0.025057003,0.019612793,0.018660778,-0.07798641,7.1301956e-34,0.047861457,0.01881847,0.017892351,-0.048021797,0.026264874,-0.011565026,-0.044517342,-0.058183294,-0.054283388,-0.09735954,-0.051527668,-0.024345117,-0.0293621,0.03101485,-0.039139092,0.04504458,0.021273175,-0.030774279,0.051727355,0.023797179,0.016975919,0.029416278,-0.005102373,-0.008631138,-0.017651135,0.014136105,-0.04971641,0.012215677,0.05667048,-0.015176627,-0.011883163,-0.01124767,-0.061828107,-0.007825761,0.043846037,-0.03260559,-0.06544419,-0.085087925,-0.0019252,0.062448084,0.00055854744,-0.016212316,-0.012105719,0.024795813,0.066693604,0.06956252,-0.020114282,0.08983066,0.054565314,-0.033089742,0.0057914695,0.0054485057,0.05847891,0.045057837,-0.012543667,-0.0014385207,-0.0055965483,0.044028115,0.019451218,-0.00599626,0.0389101,0.04172577,-0.0063092327,0.053256623,0.032896228,-0.012841705,-0.06581521,0.06301923,-0.02927628,0.009514269,-0.017842479,-0.03188127,0.015752632,0.08417997,0.043525085,-0.018802084,-0.047050674,-0.025789117,0.018081823,-0.023361314,0.0043679704,-0.08014114,-0.009702057,-0.050926555,-0.0060878345,0.022025406,-0.0065736035,-0.04031718,-0.038944986,-0.01199743,0.07529115,-0.06971374,-0.017320663,0.007295847,-0.039316364,-2.9061589e-33,0.070107564,-0.08743447,0.003806784,-0.057867482,-0.033442143,0.05327311,-0.0342964,-0.03256619,-0.03250609,0.034659784,0.08903314,-0.06394971,0.03765995,-0.037213977,-0.07857843,-0.05334874,0.042159088,0.14772639,0.018598942,-0.06544987,-0.039866444,0.018496467,0.052719936,-0.023767097,0.0039076763,-0.0058097877,-0.05078537,0.038511004,0.012500128,0.075169936,-0.022669632,0.038796812,-0.0508917,-0.027847694,0.06561086,0.013019899,-0.04750994,-0.02265548,0.07864202,0.08940138,0.06158053,-0.05110209,-0.036533494,0.018168934,0.064093694,0.005281014,-0.056955792,0.094879486,-0.04192878,-0.04155236,0.059000492,0.00787362,-0.04307813,0.018440435,0.09969501,0.06745257,0.07240704,-0.04964848,0.07482757,-0.010397598,-0.060586043,-0.06402312,-0.023781123,-0.01999571,0.041761633,0.15062726,0.039470907,0.14393318,0.0327055,-0.03602004,0.088544905,-0.03557964,0.0852784,0.06096611,-0.05883448,0.018405808,-0.002725196,-0.043620765,-0.014536056,-0.042598687,-0.00045659993,-0.057103075,0.02533494,0.0011145789,-0.040565763,-0.033202503,0.05726242,0.04753774,-0.068570666,0.013006084,0.015330042,0.027117254,0.0030152448,0.12151672,0.047550905,-3.5205794e-08,0.06811525,-0.020322554,0.06486376,-0.09776892,0.07710733,-0.012330626,-0.04835978,-0.03445756,0.049679965,-0.0063505694,0.0011811445,-0.024015894,0.033534624,-0.006258196,0.069110766,-0.010495156,0.04400432,-0.010307413,0.0054702302,0.0052835196,-0.07777151,-0.019671017,-0.10682311,0.018897878,-0.027173793,-0.08455022,0.013611294,0.10101672,-0.027348,0.005302874,0.034095895,-0.005308978,-0.062822424,0.012749713,-0.02735367,0.048651915,-0.104517154,-0.09850068,0.019778688,-0.0071840193,-0.06358671,-0.014479736,-0.04664572,0.023393665,0.008665643,-0.022510838,0.029365089,0.0526596,-0.055962104,0.00577847,0.0066036796,0.011170812,0.031604134,-0.0776994,-0.055365827,-0.0017949609,0.02679931,0.009754376,-0.08484537,-0.07705222,-0.052883655,0.00777685,0.12861381,-0.0115317525 +3.2.1.166,"Heparanase cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group [2]. Heparanase-1 cuts macromolecular heparin into fragments of 5000--20000 Da [5]. The enzyme cleaves the heparan sulfate glycosaminoglycans from proteoglycan core proteins and degrades them to small oligosaccharides. Inside cells, the enzyme is important for the normal catabolism of heparan sulfate proteoglycans, generating glycosaminoglycan fragments that are then transported to lysosomes and completely degraded. When secreted, heparanase degrades basement membrane heparan sulfate glycosaminoglycans at sites of injury or inflammation, allowing extravasion of immune cells into nonvascular spaces and releasing factors that regulate cell proliferation and angiogenesis [1].",384,1.0,-0.037032373,-0.060307164,-0.084479086,-0.029121438,0.019029908,0.0054889475,-0.040250912,0.064393945,0.0039763534,0.015865523,-0.0186008,0.112844005,0.011705347,0.046834994,-0.08066553,-0.023984348,-0.05863959,-0.061446752,-0.06024794,-0.065501295,0.114896305,0.025183529,-0.08970168,-0.059332654,0.03696274,-0.014262194,0.059581984,-0.04274969,-0.020304007,-0.051882382,-0.050807122,-0.108295456,-0.04200575,-0.0051632295,0.03584208,0.09120334,0.006461707,0.007103033,-0.0327723,-0.055769913,0.031300887,0.020933175,-0.0417798,-0.07217048,0.0149757415,-0.06980153,-0.009600501,0.02512523,0.04791369,0.03256617,-0.052883685,-0.05697508,-0.026798401,0.051971816,0.016768996,0.008307673,-0.13163778,-0.00059508946,0.040376183,-0.011663952,-0.0644668,-0.025288036,0.03501362,-0.03817875,0.052556828,-0.09839954,0.101978905,-0.026052646,-0.073435254,0.08136299,-0.019705145,0.07699622,0.024173547,0.08994797,0.056237236,0.016485766,-0.050289232,0.014463607,0.034355592,-0.02339597,0.08327629,0.08331358,0.053783797,0.14259408,-0.07725249,0.0022347956,0.0021705716,0.013905614,0.06946278,0.018722301,0.0040098885,-0.022696333,-0.017298542,-0.011556569,-0.0019026244,-0.017205287,-0.015135739,0.04831411,-0.050314274,-0.045517065,-0.016011506,0.026553443,0.0008279231,-0.052615196,-0.029403374,0.059510227,-0.0114555,0.1213142,0.085304685,0.063962,0.048335616,0.06624416,-0.0076590106,-0.10702652,-0.07239072,0.067185014,0.016046016,-0.03758975,-0.041214004,-0.037788127,-0.0539918,0.07043136,0.029173741,0.09017115,0.021525595,0.022523021,-0.024966193,4.66039e-33,0.09552723,-0.001709733,0.060946677,-0.002376135,-0.032429416,-0.0023955407,-0.01931379,0.028760614,0.012683649,-0.0489817,-0.11521801,-0.032012988,-0.004104662,0.042308155,-0.018255118,0.057657506,-0.014792922,-0.03749586,-0.030877508,-0.024057439,-0.002759029,0.042566575,-0.02250584,-0.023456126,0.06243517,0.005545919,-0.006468737,0.022325682,-0.008881279,-0.00087999867,0.008199016,-0.03089886,-0.0069569973,0.02476031,0.07664422,0.02595193,-0.05436855,-0.013476005,0.054624848,0.02783781,0.056618094,0.032301053,0.02178121,-0.046791073,-0.0055761,-0.11980822,0.022937682,0.0620662,-0.03815641,0.011359994,0.07950196,-0.0017038872,0.07854252,-0.039486133,-0.094089255,0.019456076,0.024282211,-0.08850864,0.052450385,0.054907925,0.04981699,-0.027135437,-0.002007261,0.042068496,0.027492722,0.012315537,-0.07913757,0.005456128,-0.0042692497,-0.009460002,-0.08906173,-0.06575345,0.01620301,0.0073785987,-0.034050938,-0.024619514,0.037107408,0.09413913,-0.0066240616,0.0061743637,0.014702665,-0.08976452,-0.037256483,0.016281597,-0.05803977,0.07992704,0.046726942,-0.13818589,-0.03341711,0.027477272,-0.028518764,-0.042099573,-0.06449931,0.0027087505,-0.034650534,-7.41011e-33,0.0640748,-0.060184434,0.050981473,0.025068244,-0.06597739,0.06571677,-0.002423649,0.06366402,0.018170737,-0.05237627,-0.023824297,0.06543358,0.06344819,-0.042649712,0.0029531491,0.03201267,-0.038441807,0.04560002,-0.039766606,-0.010619109,-0.029228844,0.11835077,0.029651532,0.01894213,0.07015026,-0.031339746,-0.020082474,0.00663805,0.010995689,0.09906793,0.03595731,-0.0063426695,-0.056220453,-0.07372014,-0.054456145,-0.026636897,-0.031191751,-0.123079725,0.06884512,-0.034775868,0.012098069,-0.02416541,0.0515261,0.026719118,0.009904039,0.09628037,-0.01950447,0.04471179,-0.052622274,-0.0014918054,-0.02620887,0.031091113,-0.021621607,0.10168646,0.039173823,0.034195304,0.02873103,0.036826123,-0.003402808,-0.008653911,-0.046476774,-0.0033032626,-0.01870893,-0.054176234,0.019324476,-0.000702576,-0.0059012817,-0.04680777,-0.022276245,-0.034865927,-0.05188222,-0.07559781,0.02908494,-0.03358842,-0.0335358,0.030885536,-0.0646873,0.017322605,-0.031244626,0.027065882,0.011437763,0.0012538587,0.042614587,-0.11126529,0.08784573,0.017231546,0.044231284,0.14996116,-0.015461229,0.06738723,-0.03035804,-0.05038128,-0.028699996,-0.009400428,-0.062299494,-4.841196e-08,0.040411793,0.021523753,-0.008654313,-0.04722863,-0.08579552,0.0066071874,-0.0068410854,0.057566524,0.0020856466,0.035756502,0.02068048,0.02104781,-0.06276707,-0.07452562,-0.069076754,0.036334675,-0.04570458,-0.005101583,-0.030184314,-0.036710374,-0.13682672,-0.060347028,-0.062175084,0.088683136,0.07619136,-0.04987316,0.023713328,0.017781911,-0.011716896,-0.021650454,-0.017452696,0.025790941,0.027716735,-0.08617301,-0.06910838,0.043675713,0.0013460951,0.030996336,0.10819571,-0.0016050866,0.032988787,0.045086976,-0.017681075,0.0036597978,-0.05192267,0.040214762,0.050939444,0.026950134,-0.089411944,0.047013868,-0.055268735,-0.008448437,-0.024590384,-0.09787431,-0.06450602,-0.050994337,-0.04882088,-0.06972432,0.066287845,-0.012674982,-0.02513368,0.021393491,0.083624795,0.008116374 +3.7.1.12,This enzyme hydrolyses the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde. This is a key reaction in the contraction of the porphyrin-type tetrapyrrole ring and its conversion to a corrin ring in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway.,384,0.99999994,-0.0494417,0.013590681,-0.14006472,0.04467987,0.036959764,0.035535384,-0.06037181,-0.007650624,0.0888645,-0.030343309,0.005954293,-0.031923372,-0.05059938,-0.03746025,-0.06802324,0.010585275,-0.08133596,-0.0048794746,-0.043649837,-0.083694845,-0.021772861,0.03635547,-0.014223121,0.02187753,0.033431314,-0.042788137,0.019976038,0.034654185,-0.036083695,0.0010236363,0.003228705,0.032177724,-0.034968074,-0.022061383,-0.0077302638,0.12922937,-0.024052357,-0.005211739,0.08701007,0.017980402,0.016441362,0.022739904,-0.0022096506,-0.0016574096,-0.00079418166,-0.021781439,-0.034950685,0.042182006,-0.013360661,0.009365664,-0.006470076,-0.02537858,-0.052205637,-0.06379813,0.016789109,0.0461597,-0.018749231,-0.09605995,0.04258185,-0.0042990404,0.098608196,-0.07943429,-0.046707913,0.04391994,-0.026950167,-0.059836995,0.109492235,-0.0732149,0.060510326,-0.033260416,-0.022112224,-0.04454283,0.0023560936,-0.034025423,-0.064342886,0.07235784,0.014593047,-0.08034267,0.061230328,0.028546935,0.0038324075,0.02356968,0.03778936,0.05455188,0.044504922,-0.054130044,0.013054411,-0.048814975,0.0055410564,0.07681121,-0.049327657,0.0365414,0.016802993,0.00027129805,-0.1556544,-0.02310193,0.11441953,0.041859202,-0.041279774,-0.005362128,0.014727929,0.04093118,-0.028101241,-0.06353734,0.042774312,-0.06290498,0.048030484,0.13515899,0.07835306,0.038065836,-0.037290882,0.0812216,-0.0057713664,0.0005441533,0.02192775,0.1648733,-0.0017205301,-0.032108266,-0.044377245,0.06572463,-0.0056950646,-0.027587503,-0.06265471,-0.005867904,-0.073808834,-0.034246877,0.009258044,1.6384997e-33,0.10565849,0.04701542,0.015980456,0.032514032,0.02555213,-0.028548174,-0.12323381,-0.04207385,-0.0068100784,-0.034351785,0.0021268898,-0.046488915,0.002957499,-0.0020391312,-0.05266831,-0.05452551,-0.091164134,-0.05512123,0.013770158,0.029253934,-0.05910341,0.12971923,-0.048691075,0.07403472,0.03619422,0.0847416,-0.06455603,0.061264347,0.048372567,0.025991246,0.032232504,-0.0023462933,-0.122193694,-0.030309966,0.07371206,-0.03889812,-0.02339805,0.045273993,0.02412837,0.03726539,0.07112217,-0.010664476,-0.058105845,-0.027513666,0.05170934,-0.05859661,0.00045457607,0.12108903,0.026205188,0.06632672,0.0028977748,0.006263518,0.063489586,0.053352185,-0.061385944,0.021118931,-0.012096459,-0.027795484,0.022870224,0.035885822,0.08712944,0.0045054425,0.009715999,0.088015385,-0.03518544,-0.016692828,-6.417171e-05,-0.08648146,0.05889086,-0.029452952,-0.0026574908,0.018761687,-0.001518082,0.0883778,0.01571055,0.02181409,-0.02212797,-0.07679333,0.0051347907,-0.059310544,-0.057723746,0.036741942,0.029593607,-0.060985822,-0.028998569,0.030404272,-0.026726117,-0.019012418,0.025835747,-0.0072382186,-0.00424864,-0.0305588,-0.030113429,-0.02391356,0.010843748,-3.1769597e-33,0.10624642,-0.13906334,0.05809073,-0.09181825,-0.04118596,0.06602499,0.037654806,-0.07626016,0.011078723,0.002567819,0.09700841,-0.015438659,-0.009192383,0.011109203,-0.017424045,-0.0396288,0.009814136,0.07158015,-0.00021539973,-0.01630897,0.021364085,0.014868346,-0.016570734,-0.0018082778,-0.00045674542,0.071433626,-0.051709086,-0.07595402,0.020883514,0.069061756,-0.04730091,-0.0018427194,-0.0024704223,0.046240516,-0.0024800976,0.07611434,-0.015890503,0.018459255,-0.03897247,-0.009085958,-0.025069347,-0.01020608,-0.02762762,0.05780631,0.045048006,0.045527026,-0.048341267,-0.006185062,-0.078815766,0.011978076,0.1035132,0.029999953,-0.045991935,0.004765395,0.033976644,0.060100578,0.04020835,-0.068826504,0.025748823,-0.049664848,-0.07462129,-0.014767435,0.012931743,-0.09778534,0.060756728,0.06288972,0.021202829,0.08628501,0.06584861,-0.023706581,0.07788728,0.10107854,0.007898665,0.0018247574,-0.039746083,-0.04137026,-0.015795317,-0.021335324,-0.024425237,-0.07300022,-0.036912236,0.0113457935,0.07585792,-0.024393218,-0.04939433,-0.06831398,0.052489445,0.042224385,-0.036555547,0.0600234,-0.041368924,-0.017638156,-0.056439545,-0.008730772,0.057482485,-3.8053035e-08,-0.0072579347,-0.043175295,0.040336452,-0.034994006,0.03254597,0.06021919,0.013724524,-0.03454225,0.098038696,-0.03744737,-0.004608776,0.12692057,0.034041386,0.0021667054,-0.091660015,-0.0047656046,-0.061352443,-0.002175514,0.011736911,-0.05819937,-0.10887385,0.031892892,-0.020471482,-0.023074571,0.042485524,-0.07692709,0.00059897616,0.11033859,-0.025826707,-0.012382328,0.0026189499,0.009244581,-0.020624565,-0.038371287,-0.01994606,0.040390223,-0.017388443,-0.028497193,-0.025524069,0.007998077,-0.06988128,-0.052683424,-0.09180042,0.018601343,0.0074813166,-0.02565433,-0.012587272,0.05554276,-0.04055027,-0.008569587,0.017581828,-0.0031895586,-0.023917306,-0.016033921,-0.079231605,0.02844652,0.010432476,-0.058606204,-0.058436655,-0.0064084013,-0.04568655,0.038331788,0.09072679,-0.10133583 +3.7.1.13,This enzyme catalyses the third step in the aerobic degradation pathway of carbazole. The effect of the presence of an amino group or hydroxyl group at the 2-position of the substrate is small. The enzyme has no cofactor requirement [2].,384,0.99999994,-0.023975004,0.021072878,-0.102547556,-0.020954713,0.04163355,0.042026043,-0.04296024,0.017627832,0.005466869,-0.013278561,-0.018774124,-0.032906443,-0.013174378,0.021109698,-0.015081234,0.033041954,-0.076939926,0.03865808,-0.027099844,-0.045544673,0.05780981,0.007166485,0.03778886,0.016906612,0.02009605,0.04175502,0.007880794,0.003677194,-0.03273137,-0.073843695,0.032020587,0.019704593,0.060389493,-0.03602388,0.06798565,0.06409273,-0.043262195,-0.06588318,0.022538459,0.011399476,-0.0034137152,0.052909333,-0.004602705,-0.05896347,-0.010396996,0.0036683073,0.040853407,0.007427668,0.021878328,-0.099791415,-0.064456835,-0.03221409,-0.0044559645,-0.004743691,-0.066073984,0.032273337,-0.02197899,-0.035185497,-0.068423115,0.02968967,0.057800107,-0.022164157,-0.025151111,0.0015608113,0.029783247,-0.05818995,-0.029094936,-0.046124425,-0.02218984,0.053313438,-0.11022273,-0.10620086,-0.020907382,-0.04613922,-0.050331414,-0.0018320761,0.010850517,-0.024914544,0.053951655,-0.06380977,0.011240537,-0.057037476,0.033162985,0.035659134,0.026680818,-0.016149217,0.056742206,-0.05089407,0.07000914,0.083539926,0.024140697,0.06455252,0.06161577,-0.013311538,-0.06384497,0.007718442,0.07485984,0.05222082,0.05723779,-0.028304642,0.061854307,0.04716234,0.0490515,-0.05529329,-0.056880128,0.06108733,0.06811376,0.14020424,0.100905836,-0.0032461404,-0.08292535,0.025781024,0.04327986,-0.0108495755,-0.01312794,0.115176775,0.0668058,-0.009089797,-0.051582143,0.031997308,-0.0016381004,-0.09320914,0.045182068,-0.06077856,-0.039869066,0.06861179,-0.07890906,2.4448308e-34,-0.002431353,0.02842467,-0.030146312,-0.08138669,0.02294437,-0.013761253,-0.09150154,-0.024211729,-0.00060750527,-0.071501896,-0.04034183,-0.03072865,0.02473665,0.010615416,-0.04608211,-0.022054613,-0.08820211,-0.0054391874,0.032283537,0.031882226,0.04320594,0.012350052,-0.08062085,-0.012332102,0.022547254,0.045713276,0.03974493,0.033567756,-0.09913379,0.017479599,-0.022983177,-0.054161496,-0.18203747,-0.03550619,0.06073464,0.00068618107,-0.002497715,-0.0063679568,0.010008068,0.035507232,-0.005283936,-0.03478639,-0.027081488,-0.025126057,0.009983475,-0.032752942,-0.0010456014,0.16186486,0.021267507,0.058069535,0.0542923,-0.07696528,0.1100022,-0.016752208,-0.04138187,0.09157649,-0.016183365,0.0023060986,0.041264288,-0.021404972,0.021140449,0.03452207,-0.05354666,0.07317318,-0.010284527,-0.01090048,-0.05504405,-0.015969785,0.056334317,0.08000147,-0.063306525,0.010054005,0.028384289,0.04755434,0.06312177,-0.041198067,-0.03199928,-0.035837352,0.06016635,-0.0021341247,-0.015184351,-0.032085083,0.01578996,-0.07888869,-0.0032246755,0.013648756,0.007088668,-0.041086953,-0.08593614,0.048095185,0.052830603,-0.058591228,-0.004746033,0.05088698,0.028653532,-1.2297807e-33,0.14086244,-0.03797949,0.03339307,-0.07097167,-0.0067576864,0.00013637228,0.052374877,-0.06400501,0.008907743,-0.044834953,0.0038298669,0.010173359,0.061062228,-0.0029731006,0.075287074,0.0030668457,0.0015795123,-0.026497114,-0.06849531,-0.079859175,0.0017658296,0.022552805,-0.008442732,-0.005144017,-0.03125826,0.017411843,-0.04278225,0.08721826,0.07930216,0.032759678,0.009704634,0.029482355,-0.013604911,-0.018266652,0.004883624,0.05887193,-0.050448693,-0.0022531173,0.01974524,-0.05686108,0.014727473,0.018984325,-0.032011755,0.008577173,0.076101564,0.058726322,-0.070425145,-0.007881865,-0.023270998,-0.045472637,0.051038787,0.0037331353,-0.037686788,0.030015659,0.05919434,0.09707937,0.057766523,-0.042073973,-0.0548558,0.03725969,-0.04654177,0.03985045,0.10715941,0.01627051,0.03418691,0.006184382,-0.014936842,0.13339347,0.058625653,0.024213145,0.060417395,0.04223533,0.0144462595,0.08539633,-0.06405631,0.060409345,-0.07798095,0.019267844,-0.03790527,-0.0349615,0.032423493,-0.012545743,0.016163161,-0.08215284,-0.08101217,-0.085505724,-0.052658007,0.062012672,0.032464255,0.051827375,0.038426552,-0.05029074,0.0036175456,0.08387322,0.022327088,-3.2334857e-08,-0.0026554228,-0.03691845,0.10278844,-0.05794149,0.02047531,0.11280484,-0.017449684,-0.010016033,0.13730966,-0.08186426,0.0059159403,0.022535134,0.01956572,0.10509703,-0.03754191,0.019784663,-0.030910902,-0.04891001,-0.013722708,-0.028259864,-0.10177873,-0.05759662,-0.096285775,0.07457235,0.060717072,-0.07206724,-0.0093726,0.06708448,-0.015553454,-0.060779825,-0.027590549,0.07545482,0.016111754,0.003515265,-0.063355476,0.03522203,-0.0125565445,-0.071270175,-0.065237984,0.021386476,0.027596112,-0.012926108,-0.09149705,-0.03319285,0.026767913,-0.0074601574,-0.015980488,-0.015356901,-0.062242255,-0.04542027,0.02342279,0.0118053425,-0.08714702,0.023177685,-0.049450036,0.009434661,-0.040232837,0.009714337,-0.02224187,-0.07650092,0.010639437,0.04395552,0.11682766,-0.027574055 +1.1.1.308,"The enzyme is involved in degradation of (R)-2,3-dihydroxypropanesulfonate. ",384,0.99999994,-0.022127556,-0.07326343,-0.059934746,-0.036401622,0.080809385,-0.019857293,-0.049312934,0.058043677,-0.014171245,-0.0026359712,-0.052495353,0.061570067,-0.036418002,0.031719383,-0.046138175,0.03535959,-0.060191236,-0.02873194,-0.033689145,-0.017525364,0.044841904,0.0061721276,-0.0006097526,0.0019119089,0.07647663,0.10372478,0.06978903,-0.015143005,-0.049013752,-0.012054164,0.07751352,-0.02078059,0.0059093162,-0.03869609,0.002848619,0.082463674,-0.04149247,-0.060745146,0.03076762,-0.04646723,0.0015742512,0.09015764,-0.05486668,0.009598809,-0.03683416,-0.061265953,-0.047833942,0.015793229,0.030112587,-0.064074755,-0.06871864,-0.009933439,0.010221838,0.027662992,0.03674024,-0.007513775,0.01443036,0.0085154325,-0.07786872,0.00953509,-0.017036274,-0.035220493,0.016655372,-0.035993535,-0.013930672,-0.059757147,0.054671083,-0.0052373772,0.05195584,0.049500994,-0.16944908,-0.03265077,-0.04569848,-0.020358684,0.04625588,0.039753858,-0.0007096938,-0.099433176,0.047951654,-0.06343542,0.052211214,-0.037006177,0.03236117,0.07623563,0.021268284,-0.027917251,0.052787274,-0.06876591,0.045109767,0.022915637,0.036681805,0.055166002,0.00244582,0.0019454529,-0.12438171,0.065585114,-0.039304625,0.061709296,-0.024865048,0.02211571,0.009178586,0.012484814,-0.05956285,-0.13354377,-0.098349005,0.020418977,-0.012267956,0.11332463,0.011585971,0.012007195,0.015162083,0.002186279,0.0016401348,0.05142701,-0.09043846,0.12469771,0.04596997,-0.059067585,-0.097181976,-0.038147748,-0.025329025,-0.009144659,0.03492127,-0.04775008,-0.07340916,0.011786862,-0.05283641,-2.092541e-33,0.015625497,0.024606781,-0.025122661,-0.017970107,-0.023988562,-0.013367444,-0.08372398,0.0684849,0.0029959055,-0.08510039,-0.009100632,-0.086635575,0.008062212,-0.08531016,-0.017182263,-0.004181635,0.04314498,0.055027857,0.025658546,0.014604153,0.01794118,0.051607925,-0.029545614,-0.028871005,0.023813352,0.03933572,0.03862055,0.038107812,0.012024147,-0.02156728,0.076526366,-0.06582876,-0.1465193,0.026672829,0.050859217,-0.018989729,-0.04147528,-0.018195823,0.009161222,0.021927174,-0.00573324,0.014679691,0.036943592,0.02172321,0.025731608,-0.07551918,0.0047632293,0.13845375,-0.004927005,0.098923035,0.009326051,-0.052418604,0.15187308,0.004164149,-0.037272364,0.060824394,0.0016044407,-0.05236363,0.114841215,-0.025895186,-0.017733654,0.058785845,-0.058532916,-0.0036562125,0.0139582995,0.001065476,-0.046449736,-0.01350018,-0.0027720295,0.08377279,-0.0038634255,-0.07056259,0.014429872,0.045128986,0.013021937,-0.01155346,-0.054005187,0.0007357809,0.07003075,0.031357057,-0.04352559,0.017243922,0.018478388,-0.005855388,-0.07707322,0.005836295,0.007407204,-0.06451317,-0.03567912,0.056845613,0.03644584,-0.09586309,-0.057219256,0.018579278,0.031976823,-4.6973884e-34,0.07407598,0.0006841988,0.030283961,-0.060990833,-0.049303185,-0.005604702,0.036917385,0.040304758,0.009191967,-0.03429388,0.049252827,-0.031375956,0.010016519,-0.030845234,0.03351443,0.052685335,0.009256693,0.008593517,-0.025862053,0.00042001397,0.054297395,0.11380748,-0.021519281,0.10872528,-0.04539196,-0.042612504,0.098540686,0.010860541,0.12295499,0.019953959,0.038597822,0.004527715,0.009460081,-0.002659637,-0.030204272,0.07830298,-0.021714661,-0.038503677,-0.056968004,0.039312717,0.01677896,0.041507233,0.03226079,0.083232895,0.022795795,0.011340264,-0.11391479,0.055603553,0.016642708,-0.046831712,0.018389814,-0.0073193535,-0.003171741,0.02113661,0.019608524,0.026938306,-0.024912672,0.018348949,-0.066173986,-0.011688657,-0.024764659,-0.04271285,0.010674409,0.020742856,-0.015078524,0.037609983,-0.019844696,0.016027562,0.042066198,-0.042665068,0.10810647,0.021085037,-0.012189583,-0.020722419,-0.073357455,-0.04198569,-0.09159543,0.009695671,-0.005463438,0.004468123,0.0877045,0.0091755735,0.019590296,-0.07020865,-0.04024911,-0.15324515,-0.02666334,0.086893305,-0.033151727,0.025363559,0.029067997,-0.041660424,-0.10400288,0.07626054,0.044971038,-2.67236e-08,0.015655924,-0.049362622,0.07903481,-0.04473597,-0.019222787,0.006091291,0.07981459,0.027193105,0.046702445,0.037963405,-0.042725727,0.052481253,-0.027133321,-0.0009347643,-0.018636858,0.022442004,-0.051254593,0.0345922,-0.032591425,0.0072452277,-0.069313884,-0.054630764,-0.07184664,0.016067693,0.051655874,-0.03712354,0.02266951,-0.031332336,-0.047808576,-0.032208752,0.0107996175,0.052540157,0.050075345,-0.004825988,-0.060419958,0.0047204862,-0.0017699279,-0.023715753,-0.044419773,0.06905807,-0.016431369,0.073765606,-0.074041545,0.030125286,0.012668768,-0.011183414,-0.01424787,0.0770539,-0.014173374,-0.028021134,0.09549155,0.03057483,-0.07529308,-0.073567055,-0.10333103,-0.0053800545,-0.026409201,0.0033262288,-0.056803938,-0.034018926,0.08712689,-0.014153501,0.1719772,-0.037040222 +1.1.1.309,"The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate. The preferred cofactor is NADH, lower activity with NADPH [1]. ",384,1.0,-0.00068821054,0.030641671,-0.093518086,-0.020605663,-0.025488438,0.1205855,-0.07272172,0.06219634,0.070402145,0.015633581,0.0010709517,-0.0065542916,0.022728762,0.024306884,-0.026842548,-0.012663246,-0.053764556,-0.004153872,0.052294265,-0.038593024,0.079595946,0.07255667,0.03638139,-0.03932834,0.10707017,0.050195307,-0.027346727,0.015752863,-0.01452963,-0.023991285,0.036860887,-0.0030797939,-0.0111615695,-0.12545276,0.08352835,0.067997016,-0.05299729,-0.026170388,0.07697846,0.035388313,0.003351543,0.03847996,-0.044181764,0.016841508,-0.09958163,0.028941814,-0.013722954,0.09554587,0.014099566,0.007928242,0.00801208,-0.045830473,-0.027683135,0.05627842,0.0035980751,0.08825703,-0.044426594,0.012572979,0.0031896199,-0.04709228,0.02964606,-0.041632906,0.018714173,0.029101273,-0.039124116,-0.016605517,0.033435218,-0.07930922,0.043636054,-0.029943965,-0.11682721,-0.00063151785,0.042226996,0.004228399,0.026264265,0.04814226,-0.037770666,-0.023349192,0.009501003,-0.039299123,0.07808501,-0.02414346,-0.032410644,0.085713476,0.04156598,-0.01633521,-0.0035956253,-0.043716077,0.04262027,0.01553324,0.048203915,-0.06642644,0.018728334,-0.060602874,-0.06836918,0.043525375,-0.057197984,0.031803954,0.023525223,0.007575315,-0.022545861,0.016169325,0.013076718,-0.07985557,-0.016977884,0.03151093,-0.050057728,0.047060493,0.024438735,-0.048433587,-0.0054686307,-0.0020027398,0.0188077,-0.044377465,-0.014786777,0.09883054,0.076739915,-0.07153652,-0.11938444,-0.061123498,0.052987717,-0.05384731,0.015286509,-0.0046084756,-0.05352247,0.027268404,-0.089319974,5.2495363e-33,0.050022274,0.103779525,0.035221238,-0.082142316,0.056438632,-0.009532786,-0.08701244,0.036710575,-0.035316534,-0.057110492,-0.023986144,-0.07362562,0.03836006,-0.015947247,0.028741442,0.0039759306,-0.011859168,0.04750885,0.034115337,-0.053915475,0.06113971,0.024323199,0.014351387,0.06222986,0.033083513,0.050291482,-0.03537366,-0.0035844138,0.038141053,-0.025426367,0.026163673,-0.051900797,-0.044400804,-0.010044019,0.07834458,-0.04368786,-0.11225235,-0.110929154,0.055444513,-0.022431793,-0.07465092,-0.00329484,-0.036859013,-0.039971795,0.032214403,-0.085532255,-0.0574552,0.023139734,0.044381615,0.08540522,0.018022737,0.022923874,0.10614041,0.041779,-0.10288854,0.017324954,0.031388015,-0.025078125,0.041384347,0.004950268,-0.03167091,0.010959599,0.002614933,-0.019855646,0.014458716,-0.036440242,-0.034232374,-0.03863705,-0.050755236,0.049192388,-0.035044335,-0.010554162,-0.04772912,0.025998445,-0.001263604,-0.028060673,-0.028599735,-0.019471716,0.034510043,0.0048825415,-0.019441556,0.04263837,-0.02435491,-0.04879114,0.037291422,-0.01388778,-0.028215202,-0.112138264,0.037035733,0.0543379,-0.04194376,-0.037027624,-0.026603956,0.007895307,0.005627144,-6.52587e-33,0.10029526,-0.023572043,0.03168806,-0.08509621,-0.010674711,0.079967625,0.038900666,0.02743144,0.02607608,-0.03546206,0.037886947,0.035361473,-0.0009669112,-0.033477526,0.04369576,-0.035483032,0.074848875,0.13125353,0.023534523,0.018853435,0.10495981,0.11103221,0.026119813,0.016393472,0.06932102,-0.06520739,0.015886981,0.05595971,0.042235527,0.10002667,0.01032927,-0.017737716,-0.029688597,-0.06919452,0.014632509,0.08204305,-0.07617471,0.042223006,0.060531672,0.030454153,0.07507561,-0.0074527804,0.020878743,-0.03030185,0.055733014,0.027294423,-0.14937913,0.08480479,-0.009960847,-0.06173196,0.021697616,0.07234725,-0.041001547,0.01609758,0.030479968,0.023851348,0.0042915554,-0.037581086,-0.0029822963,-0.05315209,-0.08584097,-0.016288009,-0.0043449407,-0.018909937,0.034582525,0.021778444,0.008455673,0.029546125,0.05324894,-0.04729381,0.009953724,0.0343514,-0.023565795,0.05307427,-0.01446719,-0.029599559,-0.08992509,-0.016478201,0.026315544,0.0063988185,0.04238071,0.02399078,0.06924661,-0.09019413,-0.011164522,-0.04353972,-0.015623291,0.03716507,-0.01937531,0.051046096,-0.04326118,-0.009468149,0.025054786,0.054263584,0.026136234,-3.6267053e-08,0.035653986,0.031857155,0.12184025,-0.050023012,0.0004245548,-0.084775,0.01952083,-0.052907903,-0.009685369,-0.04352777,0.045422245,-0.0010625875,0.06653319,-0.010799118,-0.017077683,0.019569144,-0.11671253,0.013294796,-0.053137906,-0.047458578,-0.03551127,-0.010378861,-0.06725607,0.09482105,0.05416544,-0.014093713,0.047799826,-0.057754338,-0.03057012,0.0077611334,0.06935722,0.017110826,-0.062313426,-0.006120984,-0.08530072,-0.015435758,-0.091965206,-0.023288721,-0.0076881885,0.012581272,-0.035244327,-0.01219883,-0.05106824,0.064430416,-0.03767523,0.026461875,-0.0068641854,-0.033640012,-0.07849291,-0.013123208,0.038475625,-0.002885924,-0.045327436,-0.055063378,-0.11858534,-0.028260455,0.06093675,-0.045381792,-0.10412599,-0.10193183,0.00058627385,-0.01882162,0.2006021,-0.04438516 +1.2.1.80,"Catalyses the reaction in the opposite direction. This enzyme, purified from the cyanobacterium Synechococcus elongatus PCC 7942, catalyses the NAD(P)H-dependent reduction of an activated fatty acid (acyl-[acp]) to the corresponding aldehyde. Together with EC 4.1.99.5, octadecanal decarbonylase, it is involved in alkane biosynthesis. The natural substrates of the enzyme are C16 and C18 activated fatty acids. Requires Mg2+.",384,0.99999994,-0.07663616,0.015123536,-0.085744485,0.0079619875,0.0143820075,0.069328524,-0.10642104,-0.0016221916,0.030275483,0.042275988,0.023646995,-0.05440936,-0.118907765,-0.01813821,-0.0515852,0.057240583,-0.026617797,0.017134085,0.027899517,-0.02059837,0.048846383,-0.007107425,-0.029655708,-0.012920858,0.028024407,0.025324605,0.022303037,-0.0077445903,-0.0052070734,-0.019992396,-0.006834079,-0.04845301,0.05326954,-0.08629784,0.041297033,0.027832633,-0.063355714,-0.06841948,0.055526618,0.03738744,0.040457405,-0.04914857,-0.090289615,0.009192139,0.008111922,-0.03577387,0.028020708,0.08840172,0.008498392,-0.08953162,0.010971831,0.030996744,-0.074784644,-0.018003557,0.016857328,-0.038361304,-0.021561578,-0.050161846,0.03580253,-0.013642847,0.05309541,-0.019932073,-0.06197504,0.049082365,0.003942957,-0.094704635,0.033644006,-0.04373442,0.07118274,0.00905254,-0.092103235,-0.06167212,0.008802344,-0.0459829,-0.00068173994,0.054247953,-0.013264898,-0.07375306,0.039765812,-0.0068154912,0.06808582,0.015086902,-0.00466823,0.061255068,0.07686223,-0.05533608,0.007018248,0.022594785,0.013436128,0.046970185,0.04652408,-0.012038982,0.025732292,-0.0026190234,-0.14551568,0.04569884,0.09743603,0.019256407,0.008970325,-0.001254169,0.007417926,0.08862312,-0.013036118,-0.12501736,-0.03898459,0.056611277,-0.04383411,0.1278171,0.049408402,0.029337242,-0.06571022,-0.03157129,-0.074930154,0.010042072,-0.019741852,0.07071233,0.027082048,-0.042482797,-0.04553963,-0.031438936,-0.033512525,-0.06347888,0.026966244,0.008661185,-0.02026178,0.009620301,-0.1283083,2.74194e-33,0.060192782,-0.022753984,-0.037293624,-0.10522355,0.09233029,-0.031049639,-0.06467439,0.03607065,-0.023209352,0.017476562,0.008565192,-0.063587144,0.03925211,0.036378235,-0.04991505,0.0019161663,-0.06597311,-0.014767653,0.02711084,0.010097855,-0.020980291,0.0628405,-0.0028700202,-8.609086e-06,0.038377963,0.0027913416,-0.059421286,0.0054553356,0.0038492193,-0.0020413639,0.0029275974,-0.0757374,-0.10955311,-0.02670623,0.09872198,-0.04070799,-0.015095329,-0.07994886,-0.027072493,0.048419848,-0.048545256,0.005238078,0.026565943,-0.04081078,0.024586737,0.027191438,-0.034890093,0.064685464,0.060608093,0.0307014,0.09099502,-0.022194464,0.056117747,0.009669875,-0.04809381,0.02279335,-0.07573273,0.02323214,0.028577335,0.01158601,0.058515415,0.029879868,-0.009045152,0.0353286,-0.0382405,-0.022467783,-0.089551695,-0.0467703,0.027703319,0.014087366,-0.014314363,0.027844708,0.078741305,-0.002636998,0.055531476,-0.015603673,-0.034479134,0.014205186,0.015558776,-0.0020697175,0.015489866,-0.008982186,0.01665545,-0.04785444,0.0007356107,0.03030471,-0.09094387,0.00030894706,0.023152536,0.027850706,-0.038294755,-0.030231403,-0.01164683,0.022914208,0.027269496,-3.846233e-33,0.10824767,-0.07653891,0.019489087,-0.09917116,-0.063015856,0.056712694,0.020338641,-0.06891702,0.021454904,-0.042889483,0.07727262,0.0233294,0.08312388,0.015078967,0.016904285,0.0032889338,0.01676697,0.10203017,-0.063486956,-0.06142635,0.023238618,0.034944687,0.018684356,0.026275618,0.054147884,-0.04642005,0.008332609,0.047302738,0.10345027,0.038855232,-0.022097195,0.03969401,-0.042419653,-0.030795623,-0.049865328,0.026985569,-0.057457905,0.032528486,0.009743926,0.12999281,0.07784331,-0.01974945,-0.05719703,0.05457613,0.068807304,-0.0014850498,-0.05525545,0.01361579,0.05328865,-0.092381306,0.09900104,0.020797078,-0.011502085,0.04974764,0.07092044,0.09788772,0.06382721,-0.059268303,0.06650587,-0.012249565,-0.024836881,-0.048617747,0.045417294,-0.042713746,0.07815349,0.09453406,0.027297292,0.07432631,-0.015286708,-0.037587754,0.11705786,0.07465187,-0.05105245,0.04148213,0.007264667,-0.059484243,-0.0007931552,-0.058985576,-0.04454425,-0.020112446,0.040638085,-0.051155522,0.041926812,-0.06566473,-0.08301157,-0.030591045,0.026512114,0.03946338,-0.066694684,0.05899794,0.028922157,0.022799687,0.007631267,0.107509956,0.026927834,-4.0123307e-08,-0.017214831,-0.02237333,0.050318163,-0.04813386,-0.023139896,0.114493,0.06459144,-0.027177894,0.019214144,-0.09520095,-0.007120423,0.049211174,0.05614929,0.09495585,0.046169482,-0.0017312317,-0.062008586,0.005660881,-0.007426854,-0.045810394,-0.05512514,-0.033478614,-0.08097037,0.08142761,-0.008842143,-0.08464141,0.03848067,0.07125072,0.0047664316,-0.051824737,-0.032781355,0.04817162,-0.009717833,0.0012662578,0.025598027,-0.0031306788,-0.024287732,-0.08802994,-0.06969566,0.028080454,-0.033559974,-0.019610608,-0.040856678,0.005952837,0.015197847,-0.01222287,0.013406591,0.06564122,-0.069474205,0.02983942,0.09084246,0.019809663,-0.006939385,-0.038519833,-0.043714207,-0.026381418,-0.039963678,-0.059655,-0.08088378,-0.040583592,0.06850171,0.015663546,0.14269215,-0.031650826 +1.3.1.85,"The reaction is catalysed in the reverse direction. This enzyme, isolated from the bacterium Rhodobacter sphaeroides, catalyses (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the presence of CO2. When CO2 is absent, the enzyme catalyses the reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity (relative to (E)-but-2-enoyl-CoA carboxylation).",384,1.0,-0.10815036,0.03747947,-0.06668336,0.02242495,0.09225141,0.055804417,-0.13005723,0.007441667,0.006732812,0.05574423,0.010102668,-0.07785545,-0.049093056,0.013615128,-0.031845167,0.017590856,-0.025696563,0.008756374,0.045526173,0.003529945,0.019009067,-0.014503204,-0.0742118,0.029268911,0.106570356,0.09581255,0.04391336,-0.017236507,-0.03690665,-0.085959956,-0.0087282695,-0.05287304,0.02209605,-0.035104595,0.0013945528,0.044083893,-0.00013407481,-0.048914213,0.06325985,0.024251828,-0.053490516,-0.011815213,-0.051469576,-0.06931028,-0.06666757,-0.046819236,-0.005803281,0.03387255,0.029617103,-0.058079623,-0.021324802,0.022747237,-0.09034523,0.009730895,0.0473193,-0.008038859,0.00081268995,-0.008955147,-0.026649231,-0.006241615,0.113986984,-0.074154586,-0.03648408,0.055786964,-0.006710868,-0.103975214,0.055937152,-0.060404014,0.030014785,-0.045839492,-0.041738473,-0.01698337,-0.0061747395,-0.021500334,0.009928917,0.038171496,0.0276113,-0.03346297,0.06164562,0.04771357,0.003615892,0.026326498,-0.024594452,0.04548097,0.041562073,-0.0027849493,-0.005018484,0.00782085,0.0628693,0.039746415,0.004114072,0.03770674,0.01834393,-0.024562798,-0.13030566,0.06963677,0.031235456,0.057796545,-0.00037665805,-0.0027212421,0.00041216973,0.10988693,-0.015225057,-0.16235855,-0.037219435,-0.01708643,-0.005388111,0.104344726,0.048701055,-0.018515524,-0.0101780025,-0.03501286,0.024811633,0.027350273,-0.014801859,0.12469164,0.07078994,-0.033259716,-0.13705976,0.02722078,0.01805229,-0.035311468,0.009062732,0.011646029,-0.01927983,0.008385087,-0.06826631,6.78065e-34,0.083966956,0.034266762,0.006182103,0.004407054,0.0050299354,0.020981124,-0.10229425,0.06832076,-0.0445505,-0.053958025,-0.0031854534,-0.0035903673,0.043178935,0.032551758,-0.01006723,-0.049413506,-0.031484824,-0.019609358,0.029425478,0.036494024,-0.00047707444,0.035371497,-0.024846515,0.021281688,0.004707855,0.022575462,-0.014726104,-0.009883758,0.0092762,0.0185686,0.071026705,-0.10625718,-0.08652453,0.0081597725,0.065441735,-0.081117176,-0.07220072,-0.013277041,-0.004320896,0.08591413,0.01622454,0.062703274,-0.08126038,-0.04750823,0.026527492,-0.05723802,0.0397211,0.07178718,0.058206704,0.027946379,0.05400983,-0.022440955,0.09283605,-0.04228104,-0.02057221,0.055896115,-0.0021659876,-0.008679586,0.04472675,0.017461589,0.05315459,0.08099866,0.02518861,0.028195955,0.0035124081,-0.016965147,-0.07238438,-0.03775683,0.0011133958,0.02650926,-0.027017,0.02713658,0.08115756,0.020464966,0.0072653485,-0.046826847,-0.0043289126,-0.011703744,0.079630755,-0.0049185543,-0.05278849,-0.0009824159,0.036598798,-0.04658696,0.02453557,0.004579867,-0.046018183,-0.051748354,-0.06090542,0.06868527,0.059674215,-0.07312328,-0.04350748,-0.06879483,0.0660257,-2.0761447e-33,0.12592772,-0.09858595,-0.032098357,-0.16686487,-0.07522019,0.07093508,0.038003117,-0.05494249,0.022401692,-0.0028049105,0.06965988,0.010386707,0.08835424,0.05404034,0.08151779,-0.002293799,0.05482173,0.028731778,-0.02794063,-0.05463063,0.022694353,0.038530655,0.051097106,-0.028114723,0.044861626,-0.020038012,-0.054035623,0.013502086,0.016156685,0.04899768,-0.003971745,-0.03513051,-0.05330288,-0.009266694,-0.027493639,0.06311721,-0.08517085,-0.015813842,0.012236855,0.011087947,-0.028119564,-0.007083478,-0.044314414,0.024182096,0.039559133,-0.055885654,-0.10283423,-0.007463979,-0.010528655,-0.07298237,0.023779422,0.048519753,-0.07146251,-0.019509146,0.0059959707,0.05346305,-0.009747867,-0.0083317505,0.003386198,-0.025295563,-0.036457337,-0.058695834,-0.016491426,-0.028079951,0.03969302,0.12340269,-0.0065164217,0.029251253,0.024182506,-0.0889799,0.10073208,-0.0019461464,-0.0018760753,0.006547269,-0.018930318,-0.054192606,-0.034549512,-0.05873315,-0.049873862,-0.05152517,-0.033991445,-0.07013032,0.0030204074,-0.053003278,-0.07774862,-0.10025486,-0.023522617,0.017304912,-0.037317507,0.05804278,-0.037479542,0.048973847,0.029768221,0.1073289,0.12626189,-3.990436e-08,-0.032934505,-0.0758869,0.11161092,0.014610931,0.03173135,0.10310181,0.023930335,-0.060308088,0.05900217,-0.0423755,0.015410109,0.07196125,0.08219024,0.03270842,0.08976765,0.062073346,0.002400435,-0.010606247,-0.026927663,-0.03461092,-0.051134866,-0.044174574,-0.0513592,0.059414715,0.0065897363,-0.022757573,0.022585599,-0.016234837,-0.012528882,-0.045345258,-0.0037122644,-0.030371418,0.031683017,0.046607014,-0.012196876,-0.022174181,-0.009040616,0.02282128,-0.07134745,0.06321184,0.0021320449,0.00061059074,-0.07133924,0.043796107,0.01291106,0.061931103,0.022844529,0.018282872,-0.050130896,-0.008272606,0.029667608,-0.01132273,-0.019909577,0.0025783642,-0.077640206,0.0562378,-0.012578945,-0.029925877,-0.07207675,0.015269052,-0.004275409,0.09247436,0.12974982,0.0027502212 +1.3.1.86,"Catalyses the reaction in the reverse direction. This enzyme from Streptomyces collinus is specific for (E)-but-2-enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis.",384,0.99999994,-0.097479336,-0.013561831,-0.113165565,0.009561515,0.023826636,0.040365975,-0.15088804,-0.012901596,0.014764475,-0.011588704,0.04698482,-0.10674544,-0.053442556,0.011409472,-0.02537177,-0.028904779,-0.0127514675,0.020434434,0.05567432,-0.049587153,0.06496899,0.03270059,-0.01475829,0.009201421,0.049422156,0.014766849,0.016078549,-0.010791106,-0.014185569,-0.14206174,0.047544636,-0.0860992,0.055237774,-0.07786161,0.02655279,0.057218023,-0.0113862045,-0.06314711,0.052547704,0.016610129,-0.01637324,-0.055510573,-0.020693552,0.023157075,-0.05267995,-0.085864834,-0.016601825,0.068610325,0.058320276,-0.07717875,0.01263307,-0.028750736,-0.12824285,-0.016863108,0.05015271,0.06743277,-0.012938678,0.012054653,-0.045470633,-0.013692463,0.12867817,-0.046990015,-0.020810267,0.016802156,-0.04045921,-0.07324269,0.0106674805,-0.06545909,0.046680957,0.008156862,-0.06571511,-0.068295665,-0.03254604,0.028031815,0.028520532,0.0788846,-0.010667933,0.017005166,-0.0023466132,0.00033551612,0.024189068,0.0035575263,-0.01539833,0.08784807,0.056582633,-0.0046298807,-0.0094561335,-0.013288036,0.07144283,0.055388536,0.06825384,-0.019180916,0.047901683,-0.009551451,-0.040974047,0.0656122,-0.032080717,0.023323469,0.009209638,-0.021427047,-0.029838435,0.06169231,-0.010064507,-0.060201928,-0.0006948149,-0.032142058,-0.047708597,0.085094154,0.05529878,-0.049203143,-0.0070301658,-0.049383655,0.054487217,0.0212503,0.00794369,0.027417477,0.049245805,-0.0684639,-0.019676832,0.020695752,-0.0087264525,0.0033130997,-0.0002606938,0.06280964,0.012298045,0.014161819,-0.054390527,-5.960191e-35,0.068877175,0.035754893,0.055785038,-0.032004457,0.018351248,-0.03564689,-0.11389689,0.010045056,-0.04347548,-0.01718429,-0.001603928,-0.056159537,0.042062003,0.092922725,0.004533383,-0.10822649,0.020921545,0.057652738,0.061089147,-0.025360512,-0.058018293,0.045178846,-0.017078504,-0.09076107,0.028870858,0.02767221,-0.06274471,0.02935115,0.08594984,0.0059684636,0.009246741,-0.08577657,-0.08230927,-0.0015460922,0.043147773,-0.04410311,-0.017482178,-0.043314297,0.030188113,0.077173784,0.005132999,0.07530172,-0.0405213,-0.03334692,0.020405822,-0.02182469,0.018299978,0.06923209,0.07490617,0.015273586,0.07064128,-0.025939936,0.09841072,-0.0047931722,-0.04490742,0.06869527,-0.009420593,0.056175675,0.021940913,-0.010984781,-0.0035415683,0.09050542,0.0017119175,0.012194218,0.0073982626,-0.029263029,-0.05917726,-0.028796263,-0.019826608,0.05556616,-0.023505175,-0.016271442,0.047374792,-0.023544315,0.025069641,0.0022606594,-0.08167704,0.03636626,0.06168936,-0.01028387,-0.034553472,0.03788639,-0.02993772,-0.06341351,-0.027344964,0.062434375,-0.051206935,-0.07614708,0.018182527,0.11881445,-0.036548685,-0.047552712,-0.0154762035,0.03899523,0.08877503,-1.4759401e-33,0.11754268,-0.1262664,0.013598949,-0.12148777,-0.070293866,0.039315414,0.019728875,-0.072291486,0.030435378,0.029290773,0.08155485,-0.024245754,0.028654119,-0.028911438,0.050740685,0.027759353,0.005869029,0.07471577,0.0070853727,-0.021384116,0.05037746,0.011203277,-0.024221072,0.038128637,0.06574098,0.043805417,0.016815817,0.03306682,-0.023414208,0.01980088,2.746221e-05,-0.07566164,-0.040873934,-0.00857375,-0.07396061,0.0876909,-0.10513602,0.044880554,0.051622562,-0.007372702,0.0076575833,0.054977063,0.05579473,0.024562148,0.042367898,-0.0856569,-0.03370659,0.036961947,0.004414624,-0.09708218,-0.021335026,0.028913552,-0.051624134,0.03201932,-0.006490114,0.06504438,0.045985483,-0.0014868221,-0.0064356234,-0.07664371,-0.0521315,-0.04091362,0.015075319,-0.09434234,0.064727955,0.062274937,-0.0534605,-0.03338936,0.051372338,-0.037843086,0.070450544,-0.0022336477,-0.023175685,0.02186596,-0.004057444,-0.042300157,-0.029596634,-0.07431215,-0.035061885,-0.009266646,-0.054818936,-0.0420921,-0.00072726817,-0.048681192,-0.065627776,-0.099537194,0.019686276,0.020285409,-0.00059366,0.078154415,-0.01699756,-0.009949672,0.042666532,0.10041693,0.09645988,-3.1959477e-08,-0.009575706,-0.09658779,0.081196405,0.037515856,-0.016372506,0.0032575934,0.006815581,-0.09189895,0.03493098,-0.062260315,-0.017062878,0.06263066,0.07240832,0.039458547,0.039978307,0.022616036,-0.0053935302,-0.041387394,0.006350716,-0.06310721,-0.095200166,-0.034352988,-0.045300003,0.023145482,0.017695222,-0.03245851,0.034413245,0.047440007,0.048551884,0.06550861,0.029195294,-0.031590134,-0.01576768,0.030757157,0.06754668,-0.035918713,-0.024081837,-0.032622874,-0.026776358,0.06101084,0.045367744,0.0032492823,-0.04199491,0.026323963,-0.036922257,0.048991144,-0.007143562,0.06367787,-0.08716876,-0.012907142,0.039751764,-0.012195018,-0.01052794,0.03174714,-0.038976658,-0.0018615172,-0.003854417,-0.029567204,-0.07181355,0.055238627,0.018682063,0.048290342,0.19896103,-0.062097076 +1.11.1.19,"Heme proteins with proximal histidine secreted by basidiomycetous fungi and eubacteria. They are similar to EC 1.11.1.16 versatile peroxidase (oxidation of Reactive Black 5, phenols, veratryl alcohol), but differ from the latter in their ability to efficiently oxidize a number of recalcitrant anthraquinone dyes, and inability to oxidize Mn(II). The model substrate Reactive Blue 5 is converted with high efficiency via a so far unique mechanism that combines oxidative and hydrolytic steps and leads to the formation of phthalic acid. Bacterial TfuDyP catalyses sulfoxidation.",384,1.0,-0.044864435,-0.038676225,-0.07883911,0.0065702912,0.12096323,0.049935333,0.0015516526,0.10984666,0.019775156,0.014063003,0.02294983,-0.0006148368,-0.028068122,0.07350484,-0.046181522,0.12587768,-0.07089049,0.019658059,-0.10022388,-0.061332602,0.017741647,0.019697884,-0.03741829,0.008575154,0.019095596,0.03264257,0.067377426,-0.027875565,-0.112722225,-0.024817944,0.01757775,-0.049921386,0.052736502,-0.09376214,0.044301413,0.015522669,-0.05345253,-0.05963435,0.0023616804,-0.0303424,-0.008412161,-0.0028332197,-0.0834162,-0.07029722,-0.029904133,0.011085707,0.08740391,0.01385794,0.031024808,0.008748298,-0.041067373,0.048965715,-0.043934938,-0.0025365022,-0.034240406,-0.03136869,-0.014577615,0.0021163994,-0.007009096,-0.008081331,-0.057629637,-0.028496506,0.045429233,-0.015088012,-0.030976975,-0.027990714,0.00090959127,-0.056455825,-0.035856534,-0.006511006,-0.04525685,-0.07079678,-0.012252136,0.046667095,0.037409738,0.07228026,0.039413612,-0.049379002,0.034636598,0.0050347312,-0.03409523,-0.0055272384,0.0496227,0.13502745,0.044637598,0.024695171,-0.010971052,-0.0041458746,0.008063513,0.018246893,0.01038392,0.058579892,0.0030162954,-0.01887774,-0.060283944,0.04728511,0.020685414,0.06313312,-0.024806837,-0.062029727,-0.041973766,0.03544935,-0.099826016,-0.10295699,0.0027190747,-0.043050766,0.043360297,0.12017878,0.06614037,-0.042634342,0.08717209,-0.0060942355,0.047501132,-0.05950149,0.01835374,0.12722841,0.01723081,-0.067941904,-0.059453063,-0.024823982,-0.0008110927,-0.01702822,-0.006807847,0.018184703,-0.054186776,-0.021972781,-0.027638786,3.2066707e-33,0.098308705,0.0766244,-0.001750769,0.01824226,-0.045909025,-0.023732672,-0.11324933,-0.004177783,0.0499797,-0.05315915,-0.06360328,-0.051388238,0.013140159,0.001563928,-0.0563963,-0.028074224,-0.019657502,-0.042204097,0.063091904,0.031362876,-0.009603264,0.068477586,-0.016588181,-0.056002107,0.009638409,0.07525371,0.04611513,0.011979531,0.02968564,0.0015871476,-0.010900118,-0.0069138967,-0.09962159,-0.056780424,0.0031142898,0.031003902,-0.07798732,0.030654965,-0.061626825,0.04349781,0.022685753,0.102539055,-0.048372723,0.023347884,0.064485945,-0.027461866,-0.061068475,0.07291784,0.05124329,0.058616325,-0.03486944,0.005259303,0.14581987,-0.013123367,-0.008400465,0.008606508,0.027805636,-0.02635056,0.07356047,0.081445076,0.027568452,0.035538353,-0.04637132,0.025249848,0.02109537,0.0058355723,-0.031186251,-0.016421463,0.034329668,-0.02712942,-0.027548999,0.058230992,0.045418013,-0.012056506,-0.03088319,-0.07540515,-0.025460573,0.06030672,0.05752072,0.002754525,-0.009742629,-0.06731488,-0.0036606558,0.020410938,-0.06375041,-0.0108997915,-0.02993656,0.049748644,-0.017271638,-0.05191474,0.068104185,-0.13310018,-0.012416665,-0.031953424,-0.03649767,-4.1927907e-33,0.089396656,-0.06980393,0.010212285,-0.04716451,0.0017782872,-0.022020679,0.019521153,0.06579306,-0.012204584,-0.0044616493,0.06577011,0.05510343,0.031017043,0.019726958,-0.024527164,0.026985858,0.050951842,0.09251286,-0.032800052,-0.03034071,-0.06393012,0.07554004,0.020072196,0.0743962,0.06493133,0.034719553,-0.02458589,-0.051491596,0.041438714,0.038305104,0.024901064,0.058217958,-0.0046452982,-0.081128664,0.07057233,0.03384645,-0.08020843,0.016143847,0.05094646,0.008101522,0.026568763,-0.062160168,-0.0359873,0.017897226,0.0004448046,0.075794145,-0.17387652,0.055373877,0.0024661252,-0.025372034,0.003459036,0.009086463,-0.050338786,-0.09107956,0.04203803,-0.016759563,0.026472349,0.004341489,-0.03254064,0.005696718,-0.07496718,0.026710315,0.09742768,0.014024726,-0.055619746,0.113970995,-0.07242201,-0.0033956622,0.052377827,-0.09466342,0.016708612,-0.039929986,0.057772428,0.0033251357,-0.01848953,-0.07657582,-0.004234306,0.06635227,0.029053062,0.101236574,0.0077880193,-0.023353782,0.02822563,-0.076512754,-0.014289563,-0.043347392,-0.016738568,0.048420943,-0.055937722,-0.03917163,0.0006221039,0.0024291652,0.0016810652,0.10081139,0.05097148,-4.0700925e-08,-0.0145212365,-0.045312196,0.11309441,0.0063655963,-0.0617252,0.071676865,0.0061131893,-0.017074795,0.077257715,0.012214567,0.014170678,0.06614824,-0.025905756,-0.01513835,-0.045604773,0.043059736,-0.013483866,-0.080881245,0.0016526863,0.0031331053,-0.08731087,0.015117269,-0.050606273,-0.013755495,0.04889074,-0.078629315,0.008092751,-0.0955385,0.05114642,-0.055277884,0.030871611,0.036752146,-0.015220241,0.032092553,-0.037409917,-0.009467492,-0.03699602,-0.026179392,-0.012794327,0.04972951,-0.05571494,-0.020118633,-0.09781727,-0.031860825,0.031667292,-0.01917807,0.017694134,0.08540581,-0.091448344,-0.02579765,-0.00040600906,-0.024277445,-0.009252355,-0.063208744,-0.07145936,0.0051422636,0.036504123,0.004658092,-0.01216201,-0.05829642,0.045546852,-0.04426557,0.16325767,0.024566244 +1.11.2.1,"A heme-thiolate protein (P-450). Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. They catalyse the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. Reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. They have little or no activity toward chloride. Mechanistically, the catalytic cycle of unspecific (mono)-peroxygenases combines elements of the ""shunt"" pathway of cytochrome P-450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle.",384,1.0,-0.08825368,-0.041687448,-0.06264154,-0.01762226,0.09664511,0.027742723,-0.030551381,0.060880486,0.05398063,0.0096685635,-0.03963025,0.009883953,-0.06135559,0.06964131,-0.02225718,0.07214962,-0.0508674,0.047715962,-0.011285131,-0.06539905,0.06278968,0.0021119379,-0.003465776,0.006498723,-0.02228287,0.044617403,0.047996145,0.036589727,-0.054785047,-0.02404915,-0.012592355,-0.023067884,0.014354018,-0.030630535,0.01084223,0.11368425,-0.09765286,0.016605435,-0.061583236,-0.05739523,0.046378694,-0.04185901,-0.13596296,-0.0027809623,0.012904713,-0.05312512,0.0097651,-0.012967289,-0.029044388,-0.058982044,-0.0018253878,-0.017391643,-0.072677426,0.0011242622,-0.039601296,-0.04990195,-0.026302796,0.023714688,0.021154704,-0.08975559,-0.039766602,0.02643162,-0.02786355,0.0187291,-0.027539184,-0.05840266,0.06685133,-0.05954717,-0.010630836,-0.049991272,-0.050716165,-0.047549717,-0.026665652,-0.028983196,-0.021658383,0.07505819,-0.004128281,-0.02447622,0.018961512,-0.045521513,0.026723078,0.057173055,0.024209317,0.09059055,0.09567806,0.024452176,-0.016865626,0.069953695,-0.019149048,-0.053744063,-0.04999439,0.020200204,-0.00054925,-0.025281968,-0.03054625,0.06513427,0.06162547,0.054546554,0.033055365,-0.024851484,0.024796601,0.094305076,-0.055946767,-0.117533505,-0.014209605,0.03594883,0.038349345,0.10036526,0.10617695,-0.014329421,-0.07383094,0.0117973965,0.048323162,-0.037370518,-0.0037694115,0.10937734,0.018219188,-0.02368802,-0.00740589,0.015240286,-0.05473189,-0.039451864,0.022018079,0.046014693,-0.039775938,0.046853393,-0.10777192,8.478944e-33,0.041228827,0.047802087,0.02274405,0.053366512,-0.030914785,-0.0148064885,-0.078180395,0.01315326,-0.0121413935,0.009068457,-0.019701155,-0.020281646,0.03506116,-0.011794749,-0.012449107,-0.08730345,0.0082046585,0.025871493,0.041286,9.492071e-05,-0.04420841,0.009516119,-0.024185183,0.043708887,0.030073157,0.062288202,-0.003535465,-0.030401325,-0.026107155,0.009884691,-0.020210259,-0.038874213,-0.036250368,-0.038501043,-0.034393024,-0.008901486,-0.09363804,0.046708696,0.003121095,0.007279643,-0.054577395,-0.020540163,-0.041957576,-0.06416376,0.053480636,-0.08943987,-0.07840356,0.13327636,0.026265912,0.071935885,0.060198776,-0.041812316,0.0729892,-0.010722697,-0.09936357,0.02634918,0.0020109396,-0.024907144,0.052858263,0.076610334,0.11537679,0.06486581,-0.08274987,0.016978938,0.012854636,0.028726298,-0.049266815,0.035295088,-0.0011240642,0.11491224,-0.040813215,0.074168175,0.05157636,0.005668015,0.035594907,-0.02832107,0.056279395,0.038406197,0.08676868,0.058548454,0.091289245,0.015879782,0.021660434,-0.024129396,-0.044947993,-0.03876797,-0.040332183,-0.017778417,-0.056357697,0.058666132,0.05501534,-0.13970733,0.01440819,-0.03176733,0.00018040642,-8.335414e-33,0.115060225,-0.05646805,0.0076595303,-0.12664124,-0.02288006,0.044439584,0.016798025,-0.050499965,-0.017382953,-0.050921395,0.060815573,-0.01588483,0.046739433,-0.019110072,-0.026508423,-0.0402617,-0.026126154,0.081760675,0.011272179,0.052995622,0.02991488,0.073458865,-0.02477643,0.030853698,0.06485699,0.034360718,-0.030061135,0.026889475,0.07182122,0.057381693,-0.041043747,0.079603925,-0.06455015,-0.052372932,-0.0016625194,0.01657205,-0.046131272,0.04966795,0.0075698583,0.016202433,-0.041076854,-0.0015272944,0.022657286,0.056261424,0.0348261,0.09059677,-0.10632466,-0.08123106,0.01948051,-0.065740556,0.026673477,0.03485836,-0.07815111,0.030229814,0.03160862,0.045363378,-0.014506009,-0.027434345,0.0017697321,-0.093838274,-0.05380198,0.010795988,0.009055418,0.07112707,-0.011152033,0.047105484,-0.050951757,0.00527961,0.024203975,-0.048667774,0.022786336,-0.016302075,0.03833598,0.00017798683,-0.010500578,-7.699773e-05,0.03256816,-0.018851774,0.030092819,0.032635294,0.032607414,0.0214306,-0.053791616,-0.09109267,-0.06599851,-0.10863156,-0.03222303,0.05182432,-0.008741163,-0.053785052,-0.025714463,0.049730178,0.011788085,0.09759029,0.081159644,-5.9995756e-08,-0.04190499,-0.07961494,0.11577185,0.013741498,-0.037583474,0.034953896,0.05241827,-0.016930733,0.03352004,-0.04039186,0.027819578,0.023541152,0.014088661,-0.06205288,0.018301707,0.030212106,-0.0038018713,0.016887419,0.021976572,-0.045404047,-0.10011415,0.0015667818,-0.044555612,0.05443546,0.04252984,-0.1297698,-0.0047776825,-0.061680455,0.043713223,-0.02569252,-0.036221564,-0.0068597924,-0.030276094,-0.029313764,0.03679814,0.01223507,-0.024271956,-0.0327226,-0.031921845,-0.010718603,0.029126646,-0.024800738,-0.03224226,-0.0056913113,0.071443066,0.03653587,0.018008815,0.022264076,-0.03664098,-0.006305136,0.05877212,-0.00011455246,-0.022883063,-0.09463973,-0.13469271,0.0805,0.07570881,-0.061929844,0.019966073,-0.08682226,0.008943101,0.0016769223,0.1605103,-0.022579834 +2.4.1.251,The enzyme is involved in the biosynthesis of the exopolysaccharide xanthan. ,384,0.99999994,-0.022082174,-0.047181576,-0.12391093,-0.03018494,0.04211895,-0.0068084104,0.02114599,0.04399305,0.012011249,0.0070613916,0.097717576,-0.047569826,-0.034958847,-0.021613248,-0.04211665,0.087237716,-0.041945696,-0.058245067,-0.017408507,0.015110741,0.08878743,0.015287443,-0.029234668,0.011342433,0.014664654,0.0016521711,0.022670789,-0.045827888,-0.010226671,-0.025988288,-0.022030737,-0.012142337,0.081201255,-0.06277834,0.06901046,0.088664435,-0.017534155,-0.02871555,0.090408735,-0.050033037,0.028806224,-0.04615685,0.0046057436,-0.040917315,-0.017316109,0.0020731168,0.020402899,0.055059507,0.0024777683,0.00013415517,-0.0014785775,-0.03606134,-0.07281699,-0.008740393,0.094844066,-0.011858713,-0.046183288,-0.014473955,-0.08370806,0.06362048,0.04673807,0.093254685,-0.011481827,0.012797929,-0.010018873,-0.08366659,0.031171907,-0.08931841,0.005854867,-0.03147207,-0.05044686,-0.051982388,0.011820723,0.0010499281,-0.04314827,0.00039931198,0.059121042,-0.021465715,-0.0035706416,-0.017570628,0.05264683,0.038674697,0.028417816,0.09717262,0.054732732,-0.0050244736,-0.02132065,0.00074576697,0.031821623,0.07428621,0.055989414,-0.051901694,-0.010859189,0.0076298327,-0.02386065,0.009320989,0.018070474,-0.065331705,0.020469923,-0.005342659,-0.013376099,0.017000392,0.01388577,-0.08136159,-0.09004212,-0.044122946,0.04136948,0.04428132,-0.015203691,0.008360727,-0.0352836,-0.07947146,0.051056944,0.024060786,-0.08584091,0.10553525,0.029367397,-0.041325163,-0.07251346,-0.05582934,0.00048123876,0.05333231,0.054862324,0.11750729,-0.049266167,0.0054828133,-0.06927821,-1.36009095e-33,0.030129917,0.027666504,0.02005502,-0.09985684,0.07062559,0.030017281,0.013643066,0.012469152,-0.027147863,0.012273749,-0.047080226,-0.14339897,0.03025317,-0.021143751,-0.02631289,0.039608672,-0.118215114,-0.0040872036,0.039590422,0.0766814,0.02035295,0.023423405,-0.046254586,0.010890211,-0.027039658,0.076659195,-0.027785394,-0.00214138,0.03549954,0.00047838676,-0.015866961,-0.0037058396,-0.15783285,0.041323222,0.038950026,0.011152774,-0.0066640233,-0.049766403,0.03556753,0.059519418,-9.763321e-05,0.035899434,0.009828125,-0.02412916,0.029522829,0.012192295,-0.05940952,0.064771876,0.09963897,0.009130128,0.045515556,-0.027412737,0.060012836,0.076970495,-0.036240026,0.016810866,-0.067986,0.01948871,-0.0035624315,0.020930093,-0.055852294,0.040930454,0.014921053,0.0084878635,-0.02429985,0.0021489335,-0.055858694,-0.06369097,-0.025502518,0.09837364,-0.063741244,-0.09352019,0.04754401,-0.030380255,0.029013831,-0.048378237,-0.08179199,0.00028515043,0.0011674389,0.02337002,0.06176879,0.017525109,0.011182088,-0.03721273,-0.070876986,0.025576934,-0.02171726,0.014238092,-0.02108009,0.041894473,0.041065842,-0.08597558,-0.03672128,0.07745016,-0.0063818335,-1.5244248e-33,0.06075208,-0.06528115,0.07918725,-0.071115054,0.00837325,0.00947267,-0.01899076,-0.02458614,-0.013158564,0.0033781324,0.034850247,-0.0019414184,0.028214833,0.059331518,0.019402044,0.049412616,-0.020829257,0.12702885,-0.02390398,-0.07092928,-0.007104213,0.075543344,-0.0034786223,-0.02382571,0.10972775,-0.0029973753,-0.011895978,0.05602015,0.029660465,0.007643757,-0.09760737,-0.047085498,-0.09546728,-0.059671164,-0.028731516,0.039222553,-0.070607334,0.022421397,0.019816965,0.045865808,-0.005759606,0.060896248,0.07428268,0.08738482,0.033679683,0.08775921,-0.086043425,-0.02533399,0.012288954,-0.021756396,0.05191668,0.009158504,0.008539544,0.029216481,0.0019861395,0.075989865,0.003963718,0.085652955,-0.058428444,-0.022366043,-0.042732857,-0.06753586,0.03784525,-0.036358498,0.04627021,-0.0039099036,0.048214316,0.03269962,0.063776284,-0.052316926,0.09038701,-0.012781453,-0.027080357,0.090526685,-0.023491904,-0.014294309,-0.10098392,-0.08948646,0.0046649715,-0.028078418,0.06782685,0.013336421,0.06735204,0.0077900686,-0.06369958,-0.06332227,0.052468956,0.11805719,-0.006579935,0.014996661,-0.0082573,0.011415773,-0.029752357,0.04637786,0.09216966,-2.4212092e-08,-0.032690763,-0.12896398,-0.0061652963,-0.07416163,-0.036150355,0.020426093,-0.012658722,0.0006011232,0.058797427,-0.045045912,0.0062717525,0.06305943,0.017771404,0.07601051,-0.00044226766,-0.04565925,0.016585905,-0.0020978604,-0.047782827,-0.026551688,-0.096974805,-0.034540206,-0.09217017,-0.031365387,-0.026949381,-0.097653694,0.019904692,0.022343023,-0.04245298,0.0001600493,-0.06979218,0.010853221,0.0074632308,-0.03885338,-0.08636488,0.10519431,-0.06542758,-0.08108166,0.016996259,-0.044881057,-0.015252131,-0.068422355,0.009741773,0.028784383,0.011096731,-0.026609965,0.04363448,-0.008151919,-0.003758147,-0.0033255352,0.046701852,-0.004982053,-0.008447866,-0.08191268,-0.07794334,0.051327083,-0.0638339,0.003224707,0.029069232,-0.018864673,-0.022926174,0.051339794,0.19316676,-0.06940502 +2.4.1.252,In the bacterium Gluconacetobacter xylinus (previously known as Acetobacter xylinum) the enzyme is involved in the biosynthesis of the exopolysaccharide acetan [1]. In Xanthomonas campestris the enzyme is involved in the biosynthesis of the exopolysaccharide xanthan [5]. ,384,1.0,-0.066306315,-0.04894301,-0.13297656,-0.025818411,0.015682852,0.025286708,0.022260098,0.031992104,0.0059365565,-0.020744717,0.08752255,-0.07342053,-0.04111559,-0.0026940214,-0.050726566,0.026699299,-0.022523653,-0.024559716,-0.008106368,-0.0026842307,0.067657694,0.042250983,-0.028230932,-0.054147013,0.04978875,-0.011307948,-0.020016288,-0.07171914,-0.011470377,-0.059562474,-0.031557057,-0.027028173,0.07503783,-0.0342321,0.10888992,0.060850225,0.0014303171,-0.04914285,0.14156236,0.00299095,0.038506407,0.0025785319,0.03700751,-0.023360828,-0.060715396,0.02127236,0.018498452,0.05472071,-0.006376278,-0.02564396,-0.013301653,-0.040315133,-0.05683422,-0.00079387805,0.08695926,-0.019787185,-0.007444594,-0.09071099,-0.037589893,0.027138619,0.05530268,0.091807894,0.028098831,0.008768692,-0.075578846,-0.111668505,0.028110433,-0.091378644,-0.015736215,-0.030433452,-0.031997357,-0.054304216,-0.0111258635,0.026172778,-0.018147932,0.011359688,0.017470626,-0.052439775,0.019475777,-0.018320676,0.025301635,0.024246082,0.030400228,0.07240746,0.008766351,-0.10033156,0.02852186,0.043301094,0.03590273,0.040867854,0.06235995,-0.06576383,-0.017133046,-0.08367167,-0.05765141,-0.019754821,0.06794113,-0.056114648,0.04432909,-0.02504984,-0.01795239,0.005779313,0.04533712,-0.046585705,-0.061013263,-0.057100635,0.023442887,0.13026886,0.009291966,-0.026624423,-0.07438609,-0.061401393,-0.005709434,-0.01966255,-0.09021155,0.0384383,0.080381535,-0.045360744,-0.111774735,0.0028672582,0.03750104,-0.011252025,0.057067536,0.114176124,-0.0045788228,0.043415613,-0.0651927,4.5287665e-33,0.0056485147,0.020034118,-0.008053888,-0.11141627,0.09400993,-0.023098907,-0.019823192,0.009154111,0.0075121378,0.011909151,-0.052544456,-0.114111766,-0.021561105,0.026072659,-0.054604035,0.07013146,-0.12889928,-0.038364496,0.049611256,0.06609185,0.025018547,0.044914756,-0.0126587115,0.03879449,0.014867445,0.064078845,0.022545328,0.007989111,0.016385488,-0.0057816403,0.020328823,-0.0624573,-0.11170184,0.03682274,0.05917564,0.048894536,0.021743385,-0.07573582,0.032133643,0.048321933,0.019820997,0.06090615,0.0124928355,-0.040706303,0.036868237,0.008350201,-0.057959784,0.020760529,0.07947581,0.01766348,0.02085168,-0.03616853,0.1031127,0.078721166,5.850111e-05,0.049758907,-0.07069591,0.066520095,-0.0010345485,0.038812168,-0.009385652,0.014952656,-0.009274516,0.015899641,-0.03539558,0.020401085,0.0092520565,-0.060868353,-0.005434696,0.049025767,-0.09132857,-0.107711084,0.043574713,0.024076907,0.027342888,-0.035864208,-0.063520886,0.008563267,0.020960033,-0.040029086,0.035096593,0.03185742,0.04396032,-0.02306767,-0.10221087,-0.01429263,-0.034767993,0.023470178,0.010409282,0.039253023,0.019895133,-0.03335996,-0.021810992,0.058068845,-0.008673714,-6.202564e-33,0.029068302,-0.077771135,0.09347387,-0.059259377,-0.018504135,0.051562183,-0.014048719,-0.016166724,-0.03560736,0.015568464,0.053513583,0.050478082,0.007740543,0.00901185,0.0057562576,-7.936383e-05,0.04962222,0.092258155,-0.047546107,-0.03548117,-0.04221355,0.03535204,0.020045826,-0.08997179,0.08437651,0.019746928,-0.033154085,0.07418178,0.0142894015,-0.016378907,-0.07852429,0.020031117,-0.037722554,-0.06412953,-0.059153423,0.0050020157,-0.028200436,0.062494997,-0.044173416,0.037289016,0.06298878,0.042510223,0.04651361,0.11056303,0.05788028,0.06569476,-0.059306048,-0.040416993,0.0124066835,-0.007936707,0.013514272,-0.013090198,-0.030744504,-0.01121074,-0.00399657,0.074221775,0.0195964,0.05405841,-0.02107222,0.005839403,-0.03980842,-0.063156106,0.058260012,-0.004648733,0.078499585,0.023115585,0.020150825,0.06218517,0.035971627,-0.041702207,0.06389785,-0.026988737,-0.04111279,0.071926884,-0.022896381,0.010512423,-0.07696482,-0.11510833,-0.00864991,-0.07631955,0.07646518,-0.03331496,0.0015374953,0.011082391,-0.050723404,-0.033697076,0.047964223,0.14018802,-0.015999373,0.007047821,-0.054841366,-0.003983652,-0.028313953,0.007258133,0.053288504,-3.8347668e-08,-0.03616178,-0.041455068,0.034313828,-0.06148105,-0.028195221,-0.00940977,-0.021302795,-0.009271675,0.10133459,-0.049618643,-0.009183091,0.096156165,0.030781813,0.038591146,-0.025199229,-0.0047294246,-0.045883216,-0.014084104,-0.008877622,0.028368559,-0.09519958,0.010789138,-0.09387272,-0.007689084,-0.045692,-0.11936735,0.032904007,0.075899534,-0.011607634,-0.011549551,-0.06591504,0.066100925,-0.026310405,-0.024889592,-0.06624513,0.05796006,-0.09915668,-0.1126532,0.064229496,-0.06094866,-0.023679947,-0.020095166,-0.0604103,0.016291091,0.0008224477,0.017981099,0.02547988,0.0014991526,-0.019204082,-0.015296866,0.039929852,-0.0071523665,-0.0123387445,-0.09816063,-0.061126694,0.044536028,-0.013648883,-0.028999874,0.041526586,0.009278985,-0.021097185,0.0034516475,0.1744854,-0.027390448 +2.4.1.253,"The enzyme is specific for UDP-D-glucuronate as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe). ",384,1.0,-0.08084059,-0.047882486,-0.028486378,0.0005965836,0.06127736,0.026298787,-0.007337839,0.056117952,-0.0032921932,-0.033844244,-0.028413275,0.023518069,-0.10160742,0.012464094,-0.07722102,0.018853918,-0.010752506,0.026213763,-0.06460887,-0.016779916,0.08085288,-0.026067898,0.07006819,-0.011993313,0.095638104,-0.020626025,0.074485205,-0.021537326,0.015221513,-0.017761972,-0.039011788,-0.0473034,0.043050576,-0.014849533,-0.045555927,0.08784641,0.005486687,-0.02257672,-0.051570546,0.012368986,0.059656445,0.006251982,-0.0065518753,0.01789349,-0.046934474,-0.067993335,-0.08366261,0.06748805,0.0025489782,0.08006747,0.0137033025,-0.08504246,-0.07924186,0.056309026,0.065533064,0.0034591479,-0.017535476,0.020089682,-0.009046629,0.014089929,0.0543517,-0.014748979,0.047970288,0.000526313,0.01503228,-0.04516284,0.039554667,-0.01658892,-0.006873637,-0.046044394,0.0066376682,-0.031018797,-0.025864433,0.024542853,0.038087443,0.052018262,-0.050548602,0.006858435,0.063616686,-0.03596083,0.052352622,0.011895162,0.038743857,0.11436908,0.037679147,0.0076332237,-0.037780914,0.052000284,0.022975342,-0.013992684,0.01652536,0.012421213,-0.08812137,-0.032459408,-0.08968826,0.018522045,0.012646622,0.06062134,-0.01267316,-0.024206063,-0.007780995,0.018954234,0.014444186,-0.12212181,-0.08174013,-0.0089599695,-0.076994956,-0.01825144,0.024631498,-0.03514031,-0.022568425,0.012293332,0.08218345,0.015322306,-0.065933816,0.0587863,-0.047004737,-0.043126028,-0.0868894,-0.008017284,-0.035009865,-0.011462668,0.067067675,0.0424642,-0.03958396,0.007144587,-0.05896806,-2.3628075e-34,0.100757286,-0.021980653,-0.010189054,-0.042655077,0.03100069,-0.008834521,-0.03976194,0.038343932,-0.066347204,-0.0002785805,-0.11127184,-0.070804104,0.035869896,0.025987023,-0.001110839,0.037641805,0.05800477,-0.063560486,0.038409084,0.004225541,0.07331296,0.06484911,-0.076418474,0.10111424,0.021881487,0.08000049,-0.059444133,0.09004968,0.08334706,-0.0072766654,-0.06150596,-0.13915263,-0.06678018,-0.02078703,-0.031063158,-0.0024304483,-0.084073566,-0.078847244,-0.037861172,-0.019904625,0.0391611,-0.044165958,-0.0069754017,0.0008495194,0.0121875275,0.013794495,-0.05163808,0.024704685,0.037951156,0.091077074,0.04711606,-0.043041036,0.022318123,0.08870093,-0.061513264,0.031838786,-0.040178377,0.011811233,0.03934956,0.034498964,0.004844056,0.005492628,0.016552541,0.0135093015,-0.03256302,0.007720985,-0.014104908,-0.023739662,-0.016799498,0.039458714,0.009463819,-0.019147687,-0.020889666,0.08600962,0.004483796,-0.03976513,0.018132586,-0.030236555,0.049563717,0.013010477,-0.023656428,-0.015441144,0.009652963,0.013467604,-0.13282672,-0.028538954,-0.01557308,-0.028587699,-0.035712972,-0.001606755,-0.045119207,-0.027247263,-0.045676976,-0.014855091,-0.0048675723,-1.31847065e-33,0.052604146,-0.09621607,0.076541,-0.03132516,0.0061804797,0.045280375,0.07497132,-0.08053706,0.0635437,-0.05060014,0.084003106,-0.08691513,0.0034139701,-0.016527517,-0.0018828274,0.079803176,-0.09755632,0.07012354,-0.02157621,0.015838029,-0.025267877,0.049012627,-0.012114642,0.042233136,0.058260515,-0.014429677,0.052654237,-0.020380734,-0.002452581,0.13336429,0.0043576634,0.0070075775,-0.08605375,-0.002955043,-0.029552864,0.049385093,0.026393421,-0.014895469,-0.024149792,0.07441734,-0.042661093,0.05239687,0.049433153,0.06340054,0.018394802,0.08210066,-0.069655746,0.063209064,-0.014677912,-0.014340745,0.06754876,0.039859742,0.0404859,0.07025898,0.037433036,0.066957764,0.0789037,-0.029515384,-0.08392366,-0.044965163,-0.040871028,-0.11785929,0.013224209,0.034710586,0.015609935,0.11439745,0.02287069,0.0569922,-0.027710259,-0.057829723,0.038375065,-0.07605723,-0.002126929,0.1160173,-0.027768997,-0.072419465,-0.037266076,0.06273923,0.015955405,-0.008440781,0.005907028,0.014346861,-0.015902353,0.0047843647,-0.022586234,-0.06352389,0.05329764,0.07521993,0.061632033,0.059777725,-0.085116476,0.037454236,-0.069850296,0.018026602,0.13169166,-3.836115e-08,0.03006742,-0.1025178,0.02496863,-0.047991972,0.02693366,-0.05818306,-0.042267036,-0.003581869,-0.038050823,0.02914768,-0.024349134,0.12460936,-0.06949343,-0.02551453,0.0051497556,-0.025475148,0.031566057,0.06793681,-0.039221887,-0.01647476,-0.036070187,0.015622116,-0.07942397,-0.022316992,-0.009949674,-0.039608356,0.02971054,0.038289957,0.040810876,-0.023985788,0.041285936,0.020960592,-0.012022473,-0.051953603,-0.08694788,0.09498768,0.00093574583,-0.03552785,-0.0065756654,0.09213026,-0.0457903,-0.043633126,0.011524045,-0.01917572,-0.038161576,-0.040028628,-0.0010097781,0.03478215,0.013512562,0.06967364,0.0092435125,-0.022416929,-0.030916655,-0.104484215,-0.070926756,0.014219965,-0.019414088,-0.02226905,-0.008621653,-0.07886507,-0.05477243,0.0110421805,0.1929387,-0.047845718 +2.5.1.94,"This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride.",384,1.0,0.002913978,-0.006741439,-0.12794739,-0.022334086,0.11190646,-0.009897807,-0.0135966325,0.038160276,0.06423643,0.0490085,0.05621263,-0.073542245,-0.026006907,-0.017414082,-0.038809855,0.04370861,-0.06728002,-0.020540524,0.00966369,-0.034190834,0.064416714,0.050874393,0.01991881,0.048283305,-0.015027804,-0.005702933,0.04974131,0.023588054,-0.056011066,-0.11612266,0.043885425,-0.00352919,0.06383212,-0.08715988,0.108771,0.053121213,-0.05974301,-0.049469028,0.0046845227,0.03583756,0.007825192,-0.03479822,0.019808315,-0.02749002,0.0095046945,-0.05511195,0.053953994,0.053145654,0.10579904,-0.027179712,-0.090444684,-0.09318151,-0.06948512,-0.03994173,-0.02164748,0.014987821,-0.08270321,-0.07954864,-0.0028156473,0.00247843,0.041328445,0.016898738,0.01596665,-0.0062547945,0.021869885,-0.03388113,0.0046266825,-0.08994123,0.000212481,-0.0233522,-0.07863152,-0.059349522,0.04614647,0.05258483,0.03392899,0.065305084,0.013097187,-0.012361812,0.010828251,-0.025798362,0.05451375,-0.0020322136,0.09712108,0.038397614,0.077585615,-0.004354824,0.10922194,-0.0017897498,0.10729109,-0.010295484,-0.022719255,-0.029357094,0.056885697,-0.015961573,-0.10370543,0.01900761,-0.097897835,0.040328942,-0.010062312,0.030438947,0.024757124,0.00895865,0.013822621,-0.084401965,-0.010203388,0.04123475,-0.017560918,0.12049908,-0.013081477,-0.0061677312,-0.060415525,0.0360791,-0.0338104,0.02320911,0.018633384,0.07614168,-0.019936536,-0.08865387,-0.016179292,0.009980652,0.040511925,-0.03499671,0.019157946,0.06027721,-0.023598053,0.09240586,-0.1360791,4.5344467e-33,0.05188336,0.04396879,0.042171583,-0.047350194,-0.04236393,-0.059528437,-0.059342217,-0.0472024,-0.09764406,-0.06395597,-0.07494215,-0.030316517,0.06074532,0.015108506,0.014671842,-0.08173061,0.023887722,-0.011832726,0.027583398,-0.027211027,0.0003236958,0.02031971,-0.03208756,-0.028487071,0.038765397,0.035561405,-0.017774416,0.0030165678,0.07804875,0.008909499,0.0143502345,-0.052988824,-0.09156292,0.06588624,0.04182502,-0.059493884,-0.013366418,-0.057049192,-0.048072007,0.058769275,-0.056902274,0.07823597,0.02157621,-0.032279227,0.07671417,-0.08373588,-0.0035248965,0.10725546,0.13328819,0.08163653,-0.012733339,0.009150499,0.10232822,0.011190856,-0.043950643,-0.00094004977,0.00075249845,0.016764184,0.037787877,0.027342431,-0.07533446,0.05364211,-0.05911524,-0.0014269918,-0.011236783,0.06378282,-0.0037905772,-0.061537158,0.018130243,0.052918375,-0.05005642,0.02838401,0.07990848,0.028027616,0.0022049241,-0.07625902,-0.030486315,-0.02714032,-0.020806694,0.022501528,0.00036728356,-0.047295492,-0.00071862905,0.05015155,-0.089742936,-0.005749776,-0.048676793,0.025420057,-0.0049562235,0.069780596,0.05560066,-0.03361347,-0.042167295,0.033623155,0.0005178861,-3.187016e-33,0.07301848,-0.051267304,0.027548673,-0.044994973,-0.063357115,0.06307418,-0.009058174,-0.021836456,0.020812852,-0.031872675,0.032570165,-0.05351331,0.102892876,-0.111821175,-0.031084146,-0.03473511,0.0330638,0.021007951,-0.02162075,0.016170446,0.009631757,0.05576076,0.059563108,-0.02035464,-0.026866844,0.030012278,0.06359821,0.07536036,-0.014893671,-0.00060832064,-0.07278739,0.05781713,-0.069840126,-0.043366205,-0.10126861,-0.006373875,-0.05081688,0.019196663,0.0029241175,0.010106219,-0.051196095,0.06989935,0.059208166,0.005903839,-0.0010413774,0.14007093,0.0031185609,0.042661972,0.008708823,-0.06928537,-0.030800046,0.030972593,0.040690616,-0.021309616,0.009924744,0.013883929,-0.0205673,-0.024282306,-0.0226762,0.014701171,0.032721918,-0.042725027,0.041136757,-0.043347675,0.11347803,0.00824826,-0.062870555,0.04662112,0.02077698,0.09588102,0.073451884,0.012478499,-0.022728875,0.041554153,-0.020771753,0.031995542,-0.07552866,-0.059854455,0.023476196,0.0011240148,0.035336908,-0.019530226,0.02916255,-0.056732308,-0.011887779,-0.01863447,0.025790598,0.030398756,0.03547156,0.06986063,0.013447799,-0.037605453,-0.010022239,0.04602863,0.058140185,-3.2145604e-08,0.035378568,-0.10270967,-0.013901229,-0.03388079,0.016308878,0.056655932,-0.002988066,-0.00807319,0.04074597,-0.03186414,-0.050394513,0.089395925,0.06321433,-0.0046306155,-0.004555145,0.05309551,0.08603246,0.05611542,-0.0076709543,-0.018389227,-0.044117905,-0.021187808,-0.10222302,0.026967995,0.011100555,-0.03008268,0.05518533,0.027718868,-0.01975066,-0.007073421,-0.110047,-0.010855806,-0.0037076194,-0.05005922,-0.019836323,0.03206168,-0.03817226,-0.009219575,-0.058660697,0.035193518,0.08866065,-0.00825074,-0.046119533,0.009375477,0.007152718,0.07598889,0.033841714,-0.0309758,-0.017210716,-0.11138531,0.06576833,-0.034699157,-0.032484353,-0.06970223,-0.11507783,0.061968137,0.001260599,-0.09379286,-0.034467407,-0.030133678,0.007855099,-0.021274209,0.11782109,-0.008777139 +2.7.1.169,"The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine.",384,0.99999994,0.020076709,-0.023434708,-0.05634006,-0.02130056,0.056480635,0.1042411,-0.014839847,0.025615359,0.06547204,0.048617467,-0.0091563165,0.0016772775,-0.0048262244,0.03799197,-0.044594415,0.007822867,-0.094864696,0.018970622,-0.02906688,-0.041917663,0.05075472,0.05173613,-0.081908986,0.018733734,0.03941555,-0.011829092,0.023227755,-0.07596073,-0.008674339,0.0010134449,-0.012806649,-0.029660966,0.02260556,-0.018917762,0.018800136,0.07630259,0.023207653,-0.09021556,0.088987395,-0.02153763,0.10006019,0.07362004,0.05695948,0.030200457,-0.05374471,0.09020526,-0.022065777,0.037011787,0.07014721,-0.030657806,-0.07505862,-0.015978338,-0.07104797,0.048907515,-0.0040697395,0.1484708,-0.07654314,-0.063522086,-0.018237889,-0.03110544,-0.016023813,-0.027456272,0.009725556,0.05066702,0.008484611,-0.012088964,0.06077637,-0.025094813,0.05224848,0.007851327,-0.06798359,-0.022422636,0.023196768,0.036753636,0.045299396,0.034713957,-0.02545345,-0.02986349,-0.055120803,-0.030829955,0.033826966,0.0015515918,0.01614262,-0.016134197,-0.008008267,-0.052613147,0.022361653,-0.049933013,0.053969346,0.03800288,0.05257308,-0.049326476,0.07856554,-0.069499634,-0.084715724,0.012457999,0.048683237,-0.06378601,0.057805575,-0.01874937,0.0034204244,0.06122744,-0.011035524,-0.03271752,-0.04193475,-0.014918731,-0.020632748,0.11482327,-0.018293535,0.05866421,0.06272414,-0.0129081905,0.11331393,-0.0026351656,-0.05656066,0.096290946,-0.016816879,-0.07362947,-0.070103474,0.004430931,-0.026443632,-0.019481253,0.0592271,0.026655091,-0.08278318,0.023038484,-0.14921576,2.3284466e-33,0.07094416,0.045967586,0.10346334,0.0053992495,-0.008280692,-0.021935765,-0.100764185,-0.03906642,0.031039745,-0.06259669,-0.060205653,-0.111950375,0.026616866,-0.014683809,-0.004319294,0.0039798287,-0.0012795378,0.05517185,0.03727023,0.07408018,-0.06961233,0.048575647,-0.008994888,-0.009362681,0.06198147,-0.0055454145,0.012243495,-0.019946482,0.03097016,0.007152694,0.01320238,-0.016460516,-0.072470464,0.046231963,0.037018053,-0.03840902,-0.067832686,-0.05758805,-0.023071079,0.038158752,-0.0076283603,0.0059679355,-0.07282534,-0.0070403162,0.0835355,-0.104363635,-0.028049283,0.068181485,0.0114255855,0.066351295,-0.036870856,-0.003151006,0.103773445,0.048471417,-0.04807173,-0.036272436,-0.04081424,-0.057308055,0.07703524,-0.007167264,0.0376866,0.03959239,-0.054715823,0.012385443,0.012293809,0.0015381663,-0.060640696,-0.070375875,-0.059647538,0.070493035,-0.013443072,-0.07300178,-0.006715166,0.07452403,0.031224694,-0.060740676,-0.044376504,-0.07616788,-0.022847136,-0.010809928,0.030918846,0.048520442,0.042848393,0.029001012,-0.0076586413,-0.041699503,0.054823052,0.042795006,0.034995943,-0.014472683,0.111438446,-0.037292857,0.0024265903,0.053375594,-0.041403044,-2.8788483e-33,0.07899539,-0.0978294,-0.018379549,-0.013285375,-0.040804077,0.007180422,-0.0049461145,-0.026649408,0.012424085,-0.044199828,0.10445587,0.028876083,-0.013859146,-0.08896962,0.02802418,-0.080006294,0.08007311,0.03446794,0.005822205,0.04079346,0.03570041,-0.004684447,0.04747251,-0.047445532,0.047334865,-0.044090215,0.021122348,0.105491795,-0.020387737,0.08579047,0.008599045,0.029854411,-0.04165564,-0.03928861,-0.10809151,0.0067883036,-0.032045867,-0.0074315695,-0.006189398,0.030590283,0.028924754,0.05846265,0.032860503,-0.012661316,0.03250256,-0.019471781,-0.08266061,0.028207956,0.061687097,-0.0583111,-0.009521939,-0.0461213,0.024576144,-0.037434172,0.016029736,-0.008021706,-0.017519193,0.06723747,0.039211776,-0.059722114,-0.07112848,-0.09112908,0.060575314,-0.034009837,0.057459623,0.04808048,-0.042998794,0.0838117,-0.00072087836,-0.0022212784,-0.025493681,0.069191925,0.05751027,0.068118304,0.040229786,-0.06403157,-0.07072875,-0.073823735,-0.0015326535,-0.042949934,-0.11634249,0.007213153,0.042230226,-0.07623401,-0.05245746,-0.051261935,0.041802894,0.06056272,-0.08311488,0.048434757,-0.02647596,-0.08922927,0.011240135,0.033087526,0.04297708,-4.1160753e-08,0.036099806,-0.020587672,0.030031297,-0.040018134,-0.019824816,0.03828251,0.06904158,-0.006545568,0.02563678,-0.036617424,-0.05149764,0.039055645,0.05902203,0.010213202,0.021482565,0.07617949,-0.054701418,0.007843664,-0.054172006,-0.035509255,-0.053045377,-0.025440866,-0.063304074,0.036652345,0.07087864,0.008186567,0.090357155,0.07281596,-0.07336896,-0.070301704,-0.017384613,-0.006717472,0.02156477,-0.039303623,-0.0949747,-0.018414162,-0.0036267466,0.018924458,-0.009118049,-3.618389e-05,-0.004874312,0.058674578,-0.10343244,0.058359712,0.064734444,0.0150070395,0.02981043,0.07069084,-0.07555878,-0.059537534,0.06940316,-0.011790008,-0.0144309485,-0.060140226,-0.05328234,-0.062678345,0.015198345,-0.050475825,-0.035027392,0.01595592,0.011779718,0.007739721,0.119944,-0.070145436 +2.7.4.25,"The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP), using ATP as the preferred phosphoryl donor. Unlike EC 2.7.4.14, a eukaryotic enzyme that phosphorylates UMP and CMP with similar efficiency, the prokaryotic enzyme phosphorylates UMP with very low rates, and this function is catalysed in prokaryotes by EC 2.7.4.22, UMP kinase. The enzyme phosphorylates dCMP nearly as well as it does CMP [1].",384,0.99999994,-0.11791053,0.039903983,-0.06654053,-0.042000253,0.054739043,0.021772955,-0.015944656,0.062752955,0.012186585,0.054035697,0.031225083,-0.06546466,-0.024089102,0.042809334,-0.0042428067,0.019349826,-0.011303739,0.08827289,0.011902245,-0.007906752,0.020270737,-0.030645022,-0.04916329,-0.018764349,0.011991396,0.0024492182,0.042407215,0.0009844365,-0.040100724,-0.04578669,-0.06444884,-0.09230528,0.07046443,-0.026919702,0.052845128,0.095600806,-0.059999626,-0.08500161,0.001237281,-0.023587786,0.09507845,0.08364143,0.048011772,0.054405257,0.009762589,0.044323772,0.07786459,0.041262876,-0.003513026,-0.058971535,0.025996922,0.038978755,-0.0065474506,0.020902703,-0.108812384,0.057867743,-0.13527694,0.011531404,0.012994457,-0.0048149303,-0.07740232,0.0028888423,0.02428012,0.039516207,0.12058549,-0.103012316,0.013593839,-0.010934687,0.058980554,-0.0068559092,-0.04808546,-0.038604934,0.038863443,0.069672115,-0.005003322,0.07256847,0.013864035,0.017886896,0.0790703,-0.0064537292,0.0322295,0.011301007,-0.032299425,-0.054213822,0.0387207,-0.022042943,-0.015071912,0.0438482,0.008853216,-0.021133946,0.04337714,0.02240725,-0.04749228,-0.031230098,-0.11554626,-0.0026034184,0.04048764,0.081848994,-0.04084665,-0.024018288,0.048199687,0.12288204,-0.0031853474,-0.029549018,0.06029359,-0.067022845,0.04979682,0.02832206,-0.008442019,0.016775014,-0.0018331481,0.038131077,-0.0075311693,-0.01591937,0.10674351,0.041004952,-0.026495816,-0.049378447,-0.029494235,-0.011258499,-0.076269634,-0.10914887,-0.040594842,0.027335906,-0.093148634,0.07326648,-0.058512423,4.2928712e-33,-0.028007258,0.0037371318,0.047592603,-0.082214564,0.007611558,-0.04283692,-0.0046559297,-0.034684524,0.002627325,-0.1186802,-0.025255522,-0.042200428,0.04663317,0.013206839,-0.12028692,-0.08274143,-0.044543505,0.035908658,0.11694434,-0.043340944,0.040021233,0.06473502,0.013845395,-0.011339136,0.072006404,0.022428196,-0.03840172,-0.003992831,0.03358443,0.02823893,-0.06585328,-0.009834873,-0.081355266,0.03343868,-0.043158438,-0.028566753,-0.07286835,-0.073134124,0.026997961,-0.021723993,-0.09162561,-0.023468742,-0.018113505,0.003618536,-0.019713627,-0.035852578,-0.0951632,0.029755643,-0.026139002,-0.031979173,0.056663584,-0.08041882,0.054060195,-0.014085917,-0.015460572,-0.043498855,-0.063380145,-0.0053035314,0.026234044,0.054463282,0.037888695,0.055992655,-0.10462376,0.048694905,0.024312189,0.011360336,-0.10637673,-0.03466602,0.06952808,0.12386099,-0.00023332943,0.028424142,0.07597176,-0.0076172836,-0.0052029006,0.021079145,0.0054034186,0.07129819,-0.059607007,0.123370536,-0.014389776,-0.02429923,-0.024838446,-0.004488457,0.05004491,-0.08307931,0.031035567,-0.013221909,0.005223648,-0.005047885,0.1001728,-0.023388797,0.029631644,0.08374112,-0.044325456,-5.8947214e-33,0.09579951,-0.036673974,0.063154966,-0.026362063,-0.04832901,0.036358353,-0.015680166,-0.067960724,0.03908635,-0.05494445,-0.024882345,-0.068261504,0.018402077,-0.0017093914,0.046521526,-0.036669955,-0.03088484,0.12651056,0.0047836914,0.04936187,-0.013470691,0.052905656,0.032133263,0.04946646,0.030704316,-0.055840515,-0.06541646,0.032144394,0.0093581285,-0.0032504709,-0.0069784345,0.11347203,-0.10714709,-0.07552959,-0.008449532,-0.021595338,-0.02833371,0.03284775,0.022460952,0.043699328,0.054500725,0.045254078,-0.027158715,0.021294165,0.015985003,0.10250014,0.033440955,0.010846107,-0.014464991,0.0083139455,0.0066445703,-0.057563517,-0.047304675,0.0418337,0.013195775,0.07945741,-0.014819923,0.0765194,0.034400463,-0.041769627,-0.059810303,-0.092039846,-0.043889653,-0.021021796,0.033273533,0.0768309,0.02988822,0.009308889,-0.06784041,0.069131285,0.022590647,0.063252226,0.007864255,-0.00583019,-0.054214794,0.06444754,-0.020883478,-0.041645236,-0.008482647,-0.07056171,-0.03374296,0.015501223,-0.0018774173,-0.0558836,-0.02317315,0.04050814,-0.005346812,0.0028463006,-0.01081813,0.0023550736,-0.049232114,-0.07838411,-0.0026632382,0.051342525,0.021993797,-4.0798014e-08,0.045793682,0.009565612,-0.00022851094,-0.05573996,-0.02588312,0.09972982,-0.040038712,0.03166374,0.09581767,0.010939132,0.055787537,0.05373323,0.055311617,-0.05897169,-0.012522439,0.027553612,-0.026870955,0.016595157,0.035011116,-0.03163294,-0.029827178,-0.02291764,-0.031437103,0.14446929,0.016023729,0.0070768716,0.03994693,0.08441726,-0.035238363,-0.060803365,0.018391723,-0.022323884,-0.010321814,0.020110203,0.0087065045,-0.010681578,-0.0045772856,-0.079237714,-0.017477065,0.039540157,-0.023020264,-0.05646577,-0.042952977,0.026275575,-0.022607645,0.018903809,0.054805193,0.017155977,-0.06979792,-0.08365565,-0.038409892,-0.038202684,-0.063484825,-0.1156222,-0.008783021,-0.0061714444,-0.03783727,-0.039247155,-0.03581824,-0.0075059435,0.022293132,0.012994125,0.10537551,-0.032106604 +2.7.8.31,The enzyme is involved in biosynthesis of xanthan. ,384,1.0,-0.017245648,-0.0042713457,-0.118936695,-0.033871517,0.04564281,0.022028778,-0.0055472613,0.028955474,0.009721534,-0.012884625,0.051618088,-0.057829,-0.07039786,-0.024517355,-0.020725211,0.098637015,-0.033209957,-0.00013383763,-0.021967158,-0.030243281,0.076726936,0.04258778,-0.043650266,0.00639674,0.02523893,0.0009288301,0.04594369,-0.07085192,0.035029978,-0.005420214,-0.014664493,-0.0142653175,0.07942523,-0.04518747,0.046955522,0.1003674,0.0044104285,-0.07564133,0.07372928,-0.029193621,0.06941768,-0.051771067,-0.008077017,-0.059185147,-0.037266172,-0.011396597,0.012276175,0.021605404,-0.014675597,-0.02075311,-0.042390518,-0.03614502,-0.056830473,-0.0031142868,0.06685801,-0.023387209,-0.03398852,-0.03777167,-0.107429236,0.048727643,0.058417454,0.087680146,0.018629933,0.009972287,0.0079658,-0.09449435,-0.015924217,-0.067661986,0.03474761,-0.054940797,-0.03858975,-0.047308158,-0.00357414,-0.022588007,-0.06699363,-0.029344933,0.055976022,-0.017228542,-0.028605843,-0.017313136,0.02880529,0.049794152,0.10077834,0.06418616,0.03475951,0.010359563,-0.022391902,0.06445094,-0.0055304784,0.06261296,0.0828906,0.011173336,-0.012658462,0.023524744,-0.0054545836,-0.0033796362,0.12415901,-0.07775282,0.03173632,-0.018271256,0.0066776723,0.05858488,-0.005491052,-0.0600262,-0.05666681,-0.033268973,0.0028667317,0.028596696,-0.04357277,0.009523439,-0.024030857,-0.060695007,0.031525318,0.0560619,-0.059895117,0.11353409,-0.006207179,0.009229242,-0.05777972,0.005271867,0.0019400876,0.015546762,-0.0061565205,0.129578,-0.04204595,-0.01959322,-0.09458135,-2.6542128e-33,0.06572533,0.07415584,-0.029956354,-0.1095026,-0.018110842,0.030667016,0.037239365,0.04419707,-0.009617748,0.0072893375,-0.047037218,-0.15349169,0.02315221,-0.035781752,-0.033015173,-0.0074247704,-0.0912304,-0.018482935,0.041366767,0.054990653,-0.0114967255,-0.03578435,-0.10952178,0.020394528,-0.043893047,0.0506493,0.020121172,-0.0066898908,0.019365693,-0.014537125,-0.042379525,-0.020606957,-0.08078007,0.051073868,0.011316247,0.011038273,-0.033834457,-0.05726852,-0.013939639,0.04928699,-0.00013741884,0.0055707335,0.011921296,-0.0541747,0.05019152,0.030492397,-0.07587507,0.041923046,0.098483846,-0.032457873,-0.007825009,0.0064766766,0.058592204,0.04071158,-0.02596282,-0.019422771,-0.0789699,0.024950871,-0.03134839,0.020340346,-0.043756932,-0.031258054,-0.014127919,0.055283036,-0.017618397,0.032529965,-0.06438197,-0.07785646,-0.019723877,0.13366303,-0.101716995,-0.092241295,0.08319265,-0.036492947,0.04484427,-0.045801267,-0.041310992,0.0072913542,0.0063049044,0.032932565,0.08461829,0.016801132,0.020871807,-0.060526382,-0.0844429,-0.01925368,-0.030048057,-0.007050862,-0.005874801,0.028672189,0.035978038,-0.087217234,-0.05358559,0.073616885,-0.010219373,4.499613e-35,0.048070382,-0.05593573,0.044390634,-0.016951505,-0.042594526,0.040813316,-0.017919192,-0.036967468,-0.0032348183,0.0104905795,0.026315698,-0.0025402375,0.023102127,-0.0038445666,0.012181317,0.093482755,0.037591074,0.114302,-0.026258973,-0.03826583,-0.021236828,0.089658886,-0.010377486,-0.07361808,0.07897524,0.010607239,-0.010561221,0.017178372,0.052668825,0.036128234,-0.013001144,-0.047088154,-0.08042191,-0.028920894,-0.025558434,0.016374733,-0.0641445,0.032526206,0.03369071,0.083242185,0.009963086,0.031714037,0.08722346,0.09963578,0.05730666,0.074466385,-0.053546533,-0.0052279225,0.03644207,-0.04111667,0.008549146,0.017931255,-0.006644213,0.009699526,0.012092811,0.072986074,0.012911399,0.05637817,-0.043929946,-0.031321134,-0.03847256,-0.06500499,0.07656377,-0.053813163,-0.007129897,0.00920244,0.032029886,0.041208707,0.09586014,0.0075733033,0.09275094,0.02227589,-0.016176814,0.08824524,-0.08950537,-0.009387932,-0.07426516,-0.100266986,-0.04135911,-0.040768106,0.06262568,0.045845944,0.07430197,-0.06363574,-0.045598358,-0.017977169,0.094476454,0.15437163,-0.008985122,-0.014425775,0.03202271,-0.0007553893,-0.048859965,0.039855715,0.09667974,-1.8642654e-08,-0.0054241354,-0.13395436,-0.0037979803,-0.04117497,-0.014811626,0.06408153,0.033930756,0.01625824,0.057162434,-0.012278556,-0.051463284,0.023978611,-0.001083593,0.06271042,0.015313312,-0.04062105,0.024589851,-0.0021319576,-0.026345067,-0.039582204,-0.051336054,-0.03384719,-0.06839643,-0.034632895,-0.026623132,-0.08539861,0.011607778,0.054320563,0.008015871,-0.016050782,-0.060565263,0.02206987,0.0391404,-0.010064556,-0.06479509,0.097871006,-0.024951492,-0.09020928,0.035969622,-0.07519157,0.015555964,-0.053100318,-0.018029453,0.03807826,0.053511277,-0.023276871,0.0488141,-0.03796359,0.007946804,-0.023099221,0.026738247,-0.0037400709,0.019485412,-0.08243846,-0.02041851,0.077531226,-0.05532839,-0.02662625,0.010212667,-0.031823054,-0.00051743217,0.011230077,0.16910551,-0.08561522 +3.2.1.167,The enzyme also hydrolyses wogonin 7-O-beta-D-glucuronide and oroxylin 7-O-beta-D-glucuronide with lower efficiency [4]. Neglegible activity with p-nitrophenyl-beta-D-glucuronide [2].,384,0.99999994,-0.075346835,-0.03709775,-0.055310328,0.0501815,0.07303326,-0.036978174,-0.017264606,0.039587427,0.06765412,-0.054825682,-0.08869307,0.08999199,-0.04321615,0.08344266,-0.030433604,0.014156089,0.016250465,0.026249152,-0.003991809,-0.1093359,0.011683646,-0.020506874,0.085711665,0.021784155,0.038169727,0.01021348,0.016051494,0.034851827,0.039389852,-0.04833553,-0.01713943,-0.032209497,0.045170322,-0.04456825,-0.008812921,0.09600273,-0.036201123,-0.041515406,-0.084829964,-0.0025798413,0.07525234,-0.014517433,0.034265477,-0.010466216,-0.059518043,-0.054820664,-0.053989876,0.0044703083,0.015659885,0.107336864,0.0052224733,-0.1407534,-0.03531848,0.061085124,0.011170372,-0.0003092523,-0.07801112,-0.044757105,0.032464698,0.07280977,0.020128243,0.057146847,0.038260456,-0.0017348009,-0.06783102,-0.039450094,-0.040274236,-0.0043220147,-0.037254214,-0.039024673,0.04095868,0.0011827268,-0.035951808,-0.007570474,-0.03144904,-0.05364719,-0.028482938,-0.0681347,0.063673995,-0.049034234,0.04955251,0.028598886,0.038379826,0.110039525,0.039430965,0.05639434,-0.09538677,0.03421103,0.03927293,-0.040542442,0.058295406,-0.0580561,-0.013591069,0.006531609,0.028259164,-0.03242328,-0.0053264783,-0.017903332,-0.08547126,0.01529363,-0.04181809,0.03450886,-0.0017466797,-0.08757086,-0.07033133,0.02479398,0.026598457,0.093199864,0.06645322,-0.04456226,-0.02237505,0.0018710572,0.07863446,0.027759464,-0.07993636,0.03142392,8.381861e-05,0.0015079731,-0.101808704,0.022589713,-0.012422037,-0.07675977,0.07297824,0.04001226,-0.035037395,0.019137118,0.003876672,3.08983e-33,0.090216324,-0.054789443,0.017018117,0.0057052914,-0.017510673,0.020840567,-0.043759316,-0.023033444,0.021741964,-0.00900766,-0.10660352,-0.026818786,-0.005136339,0.02604403,0.03476839,0.0096168965,0.06246695,1.6516486e-05,0.055135455,0.03142777,0.10817793,0.04814503,-0.088441424,0.06797676,0.038731996,0.042554166,-0.06383774,0.042260837,0.06615346,-0.016857946,-0.0022602687,-0.11236163,-0.036246803,0.043460846,0.013946797,0.021271354,-0.099441074,-0.02707949,-0.010387516,-0.0074971444,-0.033436913,-0.025904998,0.0086620785,-0.09913652,0.027973434,0.011200511,0.019964475,0.08666194,0.018452823,0.084392674,0.095613725,-0.00640254,0.01763525,0.038938254,-0.11801365,0.027839515,-0.0069950353,-0.009283216,0.09166032,0.06705162,0.010735936,-0.017836327,-0.0073408196,-0.009776742,0.005759075,0.04923465,-0.02147295,-0.034939397,-0.08145842,0.06376261,-0.020828491,0.02904589,-0.045764655,-0.012456465,0.044193007,-0.0820134,0.05764907,-0.03631812,0.035924524,-0.01393425,0.03905471,0.008516778,-0.015696557,0.028345736,-0.036042072,0.045264184,-0.05324939,-0.04148734,0.020836039,0.081747584,-0.0056138462,-0.04617996,-0.04913055,0.035969764,0.0016460335,-2.6663599e-33,0.017606596,-0.11245586,0.014211288,-0.075851835,-0.028021764,0.069215514,0.04125656,-0.055819537,-0.02083332,-0.062401805,0.08439665,0.023738781,-0.09847179,-0.02964472,0.0042696474,-0.009509361,-0.028290765,0.08464528,0.011343537,-0.0011821471,-0.037137724,0.0050717643,0.026331274,-0.03595579,0.0471634,0.03427521,-0.0030269264,-0.0043139197,0.09649609,0.10891155,-0.04800734,0.02092813,-0.050751075,0.007036206,-0.014908841,0.028855786,-0.015369941,-0.00083287497,-0.009254137,-0.03964699,0.019442718,0.06370101,0.054120935,0.06468119,0.05736263,0.12404247,-0.08464785,-0.007888918,-0.034659274,0.025315614,0.018368699,-0.0107619725,-0.007262485,0.047984768,0.046418946,0.054292884,0.023307482,-0.024829507,0.005154056,-0.05258193,-0.056592256,-0.06723499,-0.02970157,0.07629504,-0.0039448296,0.08954894,0.039152604,0.10446619,0.034869697,-0.0044865804,-0.001322889,-0.035176642,0.028778799,0.058558527,-0.009228193,-0.020129845,0.023702063,-0.032732192,-0.008311065,-0.027889345,-0.056696527,0.04596578,-0.043906543,-0.14236993,-0.020969722,-0.0269662,0.02214923,0.12180153,0.09891424,0.08707014,-0.014071838,0.0019721591,-0.053974386,0.008998207,0.060473476,-4.1124725e-08,-0.042130873,-0.1135643,0.060877446,-0.051699094,-0.00919647,-0.047844503,0.05708874,0.036486324,0.00032082334,0.00074755563,0.039638042,0.08278416,-0.045719072,-0.08700682,-0.04794922,0.06407148,0.0057289843,-0.008128793,0.023441745,-0.0019555117,-0.014922074,0.00077183155,-0.027035788,0.07343552,-0.061703473,-0.09045636,-0.006662439,0.059620634,-0.006516444,-0.025067573,0.016985504,0.059131935,-0.011521578,-0.07583513,-0.03797803,0.005255755,-0.047690716,0.03615269,-0.009654817,0.02186572,-0.03512576,-0.02070915,0.033560585,-0.009125595,0.008647081,-0.021062631,-0.007895328,-0.039509367,0.047378022,0.03374827,0.04046433,-0.01856554,-0.0066546225,-0.078789696,-0.12072114,0.0138973165,0.034564506,-0.09813392,-0.036110498,-0.11766535,-0.002704855,-0.058221504,0.15673634,0.009630801 +3.2.1.168,The enzyme exhibits high specificity towards 7-O-linked flavonoid beta-rutinosides. ,384,1.0,-0.021203473,-0.12570706,-0.09667534,0.12802427,0.054958377,0.08172044,-0.03275263,0.03363085,0.035157535,-0.030705879,-0.05444754,0.05211521,-0.10159291,-0.0022312521,-0.05991674,0.005193712,-0.0248095,0.03790332,-0.03342383,0.036659457,0.008857533,-0.08474063,0.06642892,0.016076213,0.0300406,0.037657637,0.062415827,-0.04522746,-0.002662793,-0.12733795,0.03971033,-0.038213864,0.0874777,-0.0052479077,-0.06749592,0.016851269,-0.012913913,-0.08312573,-0.08894077,0.087439984,0.056474462,0.010791369,-0.032932207,-0.012192031,0.07379463,-0.08146489,-0.035078466,0.03860072,0.11529,-0.024768239,-0.0488235,-0.080268376,-0.07952498,0.03327446,0.015829891,0.021064796,-0.035281025,-0.0776081,-0.014612771,0.1257687,0.07632533,-0.027925171,0.05203875,-0.059760027,-0.057607688,-0.023221431,-0.038783997,0.011929815,-0.04946184,0.021146119,0.029704187,-0.028851265,-0.0660633,0.038336292,0.005139836,0.028735038,-0.0380427,0.02875992,-0.047251828,-0.060654577,0.06549515,-0.047676325,0.03932655,0.043654483,0.042598177,0.018786369,0.0026315907,0.035019632,0.028970867,0.05944016,0.03158122,0.042258028,0.044649813,-0.014910519,-0.012979056,-0.017299034,0.04936752,0.012644282,-0.029345134,-0.033409953,-0.06793073,-0.020259505,-0.0011696857,-0.015718881,-0.038409576,0.010564727,-0.031862408,-0.0046220063,0.010639402,-0.077612706,0.037885755,0.025699902,0.040673736,-0.042698562,-0.08226317,-0.011600833,-0.027614392,-0.031579662,-0.035231218,0.041325007,-0.03734277,0.06511822,0.053176373,0.055616822,-0.036669303,-0.040183604,-0.060706116,-2.1286664e-34,0.041484382,0.041722413,-0.072131984,0.0008509386,-0.014150051,-0.008456267,-0.070027374,0.021118836,-0.03385393,-0.017934278,-0.016034687,-0.015805328,0.01353413,-0.0052470043,0.08817801,0.090998344,0.056782663,-0.055670224,0.027686885,-0.08020078,0.006553694,-0.04554716,-0.12489544,0.032902718,0.0029750767,0.031266116,1.3285439e-05,0.050053928,0.02840385,-0.027479984,-0.015300998,-0.083178625,0.0006065822,0.047018528,0.021867633,0.022501744,-0.053116273,-0.06960634,-0.0808714,0.032000102,0.0016904213,-0.050293896,-0.0694136,0.039097708,0.026333857,-0.0105322655,-0.008187675,0.06111312,0.0790363,0.09012443,0.0132208625,0.012263792,0.07502651,0.15585135,-0.0538947,0.066226065,-0.085517,-0.007688862,0.05823401,0.068681166,0.024188293,-0.025161002,-0.0020394723,-0.016293094,-0.010385685,0.06821995,-0.0372308,-0.013156494,-0.034743886,0.0128720775,0.029217118,-0.041038718,0.109868854,0.02528012,0.029945508,0.012066332,-0.039663333,-0.020876,0.05052556,0.006424282,-0.037395015,0.015801974,0.030920269,0.0683921,-0.040502645,0.054584276,0.009078732,-0.03388282,0.010445615,0.026982898,0.08337916,-0.08257326,-0.06548174,0.044453256,0.02187492,2.1580527e-34,0.06663758,-0.13267301,0.024495356,-0.024486024,-0.030661454,0.034803003,0.014257307,-0.11076102,-0.030175237,0.02148049,0.0763824,-0.04889025,-0.019099439,-0.031651318,-0.023939762,0.014809822,0.011432402,0.09649202,-0.038383286,-0.03414364,-0.053379707,0.035602994,0.023064988,0.076216996,0.011612799,0.002811244,0.08210955,-0.039269943,-0.0028474415,0.07717846,0.004029978,0.022810418,-0.05554982,-0.021185484,0.005953421,0.06734718,-0.027791642,-0.0036669783,0.031061925,0.023639861,-0.06989659,-0.012072673,-0.025297564,-0.045728378,0.12128828,0.06635274,-0.019350413,0.045499362,-0.00427195,-0.029095918,0.059102666,0.019514263,-0.021042343,0.023852754,-0.033804253,-0.026083466,0.0030852624,0.041140556,0.07153589,-0.011482244,0.06496931,-0.1138335,0.068136185,0.027938787,-0.020838348,0.067639716,0.045536824,0.077495575,0.025189137,-0.039649975,-0.023513472,-0.07688665,0.041578695,0.15352707,-0.023427738,-0.0025520956,-0.019862734,-0.023985991,-0.017581386,0.010013506,-0.006540278,-0.025880566,-0.037690714,-0.049321312,-0.014114736,-0.04549711,-0.019308476,0.0394664,0.064399965,0.036139727,0.00577395,-0.016353121,-0.09463964,0.01344691,0.06784299,-2.219706e-08,0.0548692,-0.08010121,0.062318455,-0.0158919,0.10342972,-0.036441624,-0.04097513,-0.024250153,-0.021183014,0.022890046,-0.098370634,0.031653244,-0.049421012,0.022797132,0.015386731,0.02731068,0.030062221,0.03193498,0.042740546,0.023890821,-0.03249885,0.05058752,-0.036511973,-0.038686637,0.0075527714,-0.120112956,0.0024015624,0.09968489,0.060792223,-0.040934213,0.13176225,0.0091555705,0.021016667,-0.0060967435,-0.07977613,0.00819842,0.052108582,0.022631558,-0.03517673,0.01345592,-0.08211564,-0.046892066,0.0062118564,0.0073667713,-0.053674836,0.047411785,-0.02891339,0.009767305,0.05381158,-0.016798219,0.06743587,-0.0007133909,-0.0008435475,-0.037658863,-0.1063879,-0.0095832525,0.012718643,-0.048554678,0.02245246,-0.07084713,-0.026969928,-0.050042782,0.11718511,-0.0280547 +3.5.2.19,"The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2]. 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+3.5.99.8,The enzyme catalyses the initial step in biodegradation of 5-nitroanthranilic acid by Bradyrhizobium sp. strain JS329. 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+4.1.2.46,"The enzyme contains Zn2+ [1]. The enzyme catalyses the stereoselective synthesis of aliphatic (R)-cyanohydrins [1]. No activity towards mandelonitrile and 4-hydroxymandelonitrile [5]. Natural substrates for the (R)-oxynitrilase from Linum usitatissimum are acetone and butan-2-one, which are the building blocks of the cyanogen glycosides in Linum, linamarin and lotaustralin, or linustatin and neolinustatin, respectively [4]. 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In nature the liberation of cyanide serves as a defense mechanism against herbivores and microbial attack in plants. In vitro the enzymes from Manihot esculenta and Hevea brasiliensis accept a broad range of aliphatic and aromatic carbonyl compounds as substrates and catalyse the formation of (S)-hydroxynitriles [1,10].",384,1.0,-0.050276812,-0.04016966,-0.005005696,-0.0017763169,0.073109604,0.07867421,-0.023692194,-0.0005414804,-0.0025986691,0.03387191,0.035768967,-0.09204469,-0.059160136,-0.0017109356,-0.046465073,0.07337384,-0.07917525,0.025070189,0.029600233,0.03843146,0.019841608,-0.029574692,-0.02117486,0.024725644,0.020114968,0.0040168567,-0.026405204,-0.06498494,-0.06689289,-0.06671076,0.028523521,-0.019166555,0.046422325,-0.05165586,-0.0030970995,0.06910751,-0.015587445,-0.11352956,0.08590423,0.027353924,-0.03643728,-0.04185809,-0.015111533,-0.09091023,-0.029084798,-0.014457092,-0.013826702,0.03496129,0.017607499,-0.062726796,-0.03181976,-0.072759554,-0.045270488,-0.0042459057,-0.010575441,-0.04496756,0.031903133,0.033118453,0.04522634,0.08411497,0.0421167,0.029705767,-0.04086252,-0.013830508,0.00040878376,-0.10887064,-0.024917142,-0.00067666033,0.043567777,-0.011043582,-0.021106012,-0.08411943,-0.024481341,0.076674744,-0.04871976,0.040295504,-0.021661118,-0.019344447,-0.021446213,0.047855478,0.013812703,0.06932865,0.01818805,0.08120803,0.06738363,-0.014730382,-0.048671827,0.047921546,0.107256256,0.09553919,0.053505503,0.026687965,-0.0013693579,0.030889334,0.0004018024,0.027955059,0.14190328,0.00932183,-0.016259044,-0.038417164,0.004517277,-0.061927933,-0.05491725,-0.050740883,-0.037296508,0.026814232,0.041848764,-0.029900437,0.06933941,-0.009464587,-0.03045582,-0.037177674,-0.06892162,-0.06092976,-0.13000332,0.08745775,0.030135976,-0.020977816,-0.011612322,-0.05072255,-0.019328365,0.015390401,0.016291209,0.017736915,-0.02705094,0.03469817,-0.06337267,3.659382e-33,0.068785444,0.0112230815,-0.06531352,0.025632352,-0.023508387,-0.016764324,-0.04407439,0.060812797,0.07149664,-0.12382477,-0.09710412,-0.04278777,0.025281776,-0.013945379,-0.012369649,0.019404748,-0.02559658,-0.058272097,0.088826336,-0.0062170536,-0.010062934,-0.11258105,-0.10652679,-0.008522335,-0.08469783,-0.023410827,0.027145086,-0.031914353,-0.011920455,0.009364933,-0.030941134,-0.14641221,0.001962034,0.018706318,0.0594079,0.031871147,-0.026849778,-0.05760425,-0.012520355,0.041827857,-0.032243952,0.0006934813,0.020189157,-0.05319059,-0.0037751892,0.039196216,-0.09134901,0.039446373,0.02421774,0.044676617,0.052440476,-0.040401414,0.05029683,0.043003723,-0.07630543,0.119893424,-0.0136319,-0.07365089,-0.0006828014,0.058608197,0.017696038,0.030411117,0.06880714,-0.040121365,0.018971257,0.018835915,-0.024377035,-0.0015216719,0.040389273,0.0099516595,-0.12522006,-0.04500412,0.13263454,-0.02744653,0.077799134,-0.0044513335,-0.020883376,0.0733176,0.077127755,0.10390386,0.057492368,-0.0022557764,0.080572814,0.0021720924,0.012875747,0.014843037,-0.0035786263,-0.032791138,0.019506613,0.052148327,-0.026592424,-0.13585167,0.011409736,-0.026261324,0.02877207,-4.8850775e-33,0.07668738,-0.037482344,0.023451746,-0.03941029,-0.068478994,0.029503541,-0.04590313,-0.019964475,-0.03237754,0.027709546,0.01526856,0.017106408,0.061689384,-0.037678644,0.023357235,-0.060384873,0.016312756,0.029644486,-0.032804344,-0.013446896,-0.026818434,-0.019917814,0.014304313,-0.02616587,0.08157407,-0.061218567,0.03716279,-0.008785611,0.067694955,0.029260373,0.0076405792,-0.025912743,-0.035274394,0.00056804105,0.09446644,0.0606247,-0.07423769,0.002927473,0.06468607,0.03835032,0.03035794,-0.061308928,0.019264312,0.07215124,0.0044013825,0.040315095,-0.08843843,0.0454963,0.027500367,-0.016628435,0.061143532,0.04077918,-0.052666858,-0.00017642403,-0.00018680232,-0.017265044,0.047650553,-0.0008631197,0.02023426,-0.023181057,-0.033329763,0.0110461945,-0.043058895,-0.013800747,-0.038054973,0.047010254,-0.039175026,0.07219008,0.061724152,-0.057689063,0.081594355,-0.014544722,0.093086526,0.03515529,-0.07972018,-0.046579488,0.01030636,-0.07408185,-0.030229459,-0.045976624,0.14066932,0.0024777635,0.025552986,-0.100489005,0.028517434,-0.021982761,0.020197779,0.07107291,-0.07019849,-0.001297933,0.025807168,-0.004069462,0.00035705007,0.10185873,0.10853619,-4.2815937e-08,-0.022261929,-0.0447181,0.008829625,0.037088368,-0.029473005,0.034786522,-0.013108871,0.015691634,0.04296554,-0.05410355,-0.0041085663,0.031222941,-0.0017523587,0.084258854,0.02082112,-0.033499394,1.3083705e-05,0.033607524,-0.023247352,0.10355687,-0.082351185,-0.0016298791,-0.07850572,0.009746114,-0.041828018,-0.05769185,0.025045816,0.022947017,0.061559778,-0.052897986,0.034835543,0.050465196,-0.054674488,0.080660544,-0.048193198,0.021852532,-0.06720501,-0.08013385,0.003240574,-0.019225055,-0.0521352,-0.0034609784,-0.039712876,0.0005913606,-0.042741533,-0.026893128,-0.05335468,0.10683524,-0.02058347,0.055174645,0.06413648,-0.04399242,0.053501148,-0.049740296,-0.009203284,0.0021627615,0.05054949,-0.04387605,-0.054002687,-0.049414296,-0.021813178,-0.009046249,0.16905616,0.024595635 +4.1.3.41,"A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans IFO 13301, is strictly D-specific as to the alpha-position of the substrate, but accepts both the threo and erythro forms at the beta-position. The erythro form is a far better substrate (about 100-fold). The enzyme can also accept D-allothreonine, D-threonine, erythro-3-phenyl-D-serine and threo-3-phenyl-D-serine. Different from EC 4.1.3.14, erythro-3-hydroxy-L-aspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+.",384,1.0,-0.086650044,-0.116587505,-0.11984606,-0.082707986,0.008569319,0.0061472207,-0.047011364,0.03406559,0.0054822527,0.046889134,0.0023344196,-0.004378353,-0.05666973,0.09344129,-0.02668617,-0.028824946,-0.025325675,-0.015858019,0.04382336,-0.036880735,0.09883378,0.030712202,-0.055689037,0.007987138,0.068745784,0.014472291,0.055457283,0.026477957,-0.04781334,-0.0526114,-0.09963979,-0.10813632,0.04558177,-0.059061952,0.10764705,0.101210184,-0.0988864,-0.0490412,0.046585154,-0.03827556,0.044644844,-0.017542088,-0.00602117,0.036585033,-0.012388417,0.026315503,0.03495998,0.09219034,0.07776376,-0.042240728,-0.034752183,-0.014725468,-0.061332267,0.025183402,-0.017846778,0.011072607,-0.035371624,0.0016876104,0.0237474,-0.04633871,0.013439284,-0.0327532,0.031748038,-0.009697215,0.021557046,-0.010473091,0.033850055,-0.09515418,-0.018128488,-0.009589889,-0.028865123,-0.040723722,0.024849819,0.052986033,0.033178333,0.051489048,0.015494366,0.0019586307,-0.0320979,-0.026531756,0.07553214,0.03544282,0.029287871,0.07148988,-0.009028665,0.002292754,-0.015610837,-0.016428767,0.013124403,-0.015606241,0.07495015,-0.042975925,-0.045413613,-0.009941672,-0.02568647,0.027957529,-0.029083176,0.053556822,0.03464295,-0.033822086,-0.022979187,0.027193243,-0.01949613,-0.0460008,-0.0014819744,0.004787937,0.009564595,0.07296304,0.06379723,0.017220397,-0.0361018,0.025973065,0.015618198,0.06372847,-0.009219265,0.034721967,0.072006576,-0.073114686,-0.086296804,-0.053286307,0.034888893,-0.032486368,0.077457726,0.06219092,-0.005279309,0.006118509,-0.11048231,3.4536145e-33,0.087721236,0.026877325,0.034943476,-0.035555754,0.0041845753,0.01745997,-0.07494252,0.032094907,-0.019773655,-0.05609338,-0.10752464,-0.09657875,0.060782496,0.085052565,-0.07318981,0.006010072,-0.036054518,0.07457546,0.034326572,0.030629165,0.02873411,0.05815284,-0.03053227,0.035074964,0.001406746,0.05284443,-0.031284537,0.061058395,0.0039739446,-0.04156606,0.011902564,-0.15476924,-0.06533955,0.0118603315,0.045333315,-0.050586056,-0.05566462,0.0073469323,-0.018069623,0.017354349,-0.031522587,0.08586764,-0.047600463,0.008090273,0.044819828,-0.12424243,-0.006841993,0.073089,-0.00842631,0.08649052,0.016330637,-0.009752862,0.11507285,-0.07309896,-0.07634311,-0.06824567,-0.0128082,0.046777096,0.09149407,0.022256596,0.108159654,0.046849415,0.00865949,-0.0008960004,0.023510937,0.03816025,-0.082336865,-0.037142176,0.036827426,0.07667113,-0.025373224,0.00545193,0.023152208,0.021900965,-0.020729225,-0.077682786,-0.047755923,0.040245328,0.015422397,-0.032834366,0.0003524559,0.0075964113,0.014076182,0.060026802,-0.06521428,0.023460865,0.032125257,-0.03134429,-0.022286879,0.04018146,-0.0024113066,-0.03885854,-0.07299621,0.035652682,0.029565776,-3.346573e-33,0.13815083,-0.073396645,0.06396276,-0.049454097,-0.062104184,0.07096976,0.0582042,0.022303568,0.052599806,-0.011674128,0.12809914,0.010461919,0.016393092,-0.038732518,-0.0077011287,0.0071890173,-0.068657435,0.026345825,-0.040563725,-0.04092806,-0.015855195,0.064129815,-0.01775998,-0.011679698,0.03134862,0.026942963,-0.03185389,0.06299394,-0.050733004,0.03699814,-0.015618534,0.04428776,-0.06365522,-0.0577352,-0.061206184,0.07664237,-0.10353731,-0.009159891,0.01123632,0.02123513,0.081459284,0.074605696,0.034279086,0.038468592,0.038923983,0.04514273,-0.014066464,-0.0013397355,0.02120478,0.014256218,0.027885687,-0.0066070147,-0.0132961385,0.03156791,0.054595068,0.04764137,0.024905605,0.07945835,-0.062097307,-0.007288876,-0.07824511,-0.06833066,0.05271525,-0.015577493,0.046121646,0.038891155,0.016374921,0.06737428,0.03427362,0.03347238,0.09224511,0.0044216267,-0.006209583,0.015745906,-0.06965416,-0.029038206,-0.044520263,0.032937143,0.011731411,0.010433155,-0.023876136,-0.013018655,-0.06613368,0.0008617907,0.038381107,-0.0035827581,0.064078644,0.048033234,-0.054292925,0.019714827,0.02508214,-0.08062786,-0.02488531,0.048295006,0.070723094,-5.4436004e-08,0.09042275,-0.01602892,-0.02625269,-0.029875683,0.011361303,0.0033437982,0.038869604,-0.027475292,0.022503767,-0.01344722,0.047954574,-0.035205822,-0.02917498,-0.030007754,0.07519787,0.006145052,-0.08454,0.042014524,-0.027972434,0.028690519,-0.030739645,-0.055653837,-0.1683067,-0.003689212,0.11016921,-0.062647186,0.011624748,-0.027729677,-0.033809632,-0.03816336,0.0416691,-0.016363733,-0.011528326,-0.07376256,-0.015778143,0.019767942,-0.11368958,0.0556987,-0.037960455,0.031531736,-0.044185173,-0.04207364,-0.02254096,0.0027797837,-0.006124596,0.07456822,-0.030607946,0.0040534814,-0.084746994,-0.0058942223,0.05077077,-0.056477405,0.033580195,-0.10134794,-0.12630348,0.08297038,0.0035719532,-0.04987828,-0.00030217128,-0.010589173,0.06215806,0.009471279,0.09834627,-0.001985912 +4.2.1.121,"A heme-thiolate protein (P-450) [2]. It catalyses the selective removal of pro-R hydrogen at C-8 in the biosynthesis of colneleic acid [4]. It forms also (8E)-9-[(1E,3Z,6Z)-nona-1,3,6-trien-1-yloxy]non-8-enoic acid (i.e. colnelenate) from (9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate. The corresponding 13-hydroperoxides are poor substrates [1,3]. The divinyl ethers colneleate and colnelenate have antimicrobial activity. ",384,1.0,-0.0550074,-0.017837727,-0.03868931,-0.021059433,0.17764807,0.046673127,-0.06298979,0.15171532,0.037305385,-0.026113994,-0.04560299,0.032087922,-0.069986805,0.010850786,-0.05321924,-0.00086157484,-0.050578013,0.027988007,-0.016765669,-0.019408664,-5.528632e-07,-0.0018652787,0.021059986,-0.0036681818,0.040035304,0.0830885,0.08734322,0.026589582,-0.052733418,-0.053428024,0.050529268,0.010353575,0.10177644,-0.034080587,0.009259925,0.07344447,-0.051326886,-0.0629012,0.121180385,0.034296267,0.007978624,-0.030755248,-0.08735229,-0.052733857,0.016476313,-0.052776974,0.055165607,-0.003875349,-0.023288384,0.026895422,0.005773256,0.0745941,-0.054630537,0.076410465,-0.058193255,0.016237361,-0.022487393,0.024992745,0.011511552,-0.014094238,0.03957726,-0.016048012,0.025623592,0.009654121,-0.07271285,-0.09646417,0.04190509,0.04627458,0.038454406,-0.0071950317,-0.04337946,0.009065541,0.043810897,0.031052675,0.015981626,0.096381,0.0006611138,-0.053389017,0.022286756,0.011622031,0.040313162,0.0379337,0.03556875,0.15608983,0.06089201,-0.030518552,4.2109183e-05,-0.00959969,0.0004355712,-0.00334357,-0.0026970592,0.07532898,0.0038595044,-0.034689177,-0.07693779,0.06367324,0.08709283,-0.021209748,-0.008500573,0.03130543,-0.034616962,0.004159422,-0.068149745,-0.093144685,-0.03469944,-0.03229727,-0.020996569,0.10041534,0.046435982,0.009923125,0.03260618,-0.041703183,-0.07045124,0.014607936,-0.023721762,0.0999606,0.04488759,-0.08541612,-0.0111655565,-0.05231735,-0.04082404,-0.05354845,0.09084976,0.029810108,-0.09443402,-0.031603016,0.0010989909,3.665869e-33,0.0021991723,0.03779912,-0.04967676,-0.03051441,0.042567935,-0.047560964,-0.121676534,0.10657947,0.02343815,-0.002330184,-0.030477224,-0.013293414,0.06982951,-0.09402487,-0.009529711,-0.011611905,-0.019765785,0.022951981,0.0052294917,-0.035299495,0.01482137,0.00843622,0.004732121,0.04570724,0.03963031,0.001176598,-0.0036733567,-0.037324592,0.10012092,-0.020164086,-0.020126585,-0.0259447,0.047920562,0.026920516,0.034729347,0.017116241,-0.09537658,-0.029570833,-0.03469637,0.02145078,0.024205761,0.035615366,0.010680497,-0.07552869,0.070332505,-0.04635054,-0.04127155,0.024218285,0.016977279,-0.012964005,0.039934,0.02286351,0.10071605,-0.025527019,-0.013870464,-0.041577656,-0.0152982855,0.05914128,0.085005574,0.041126296,0.027739812,0.035403118,-0.028388878,0.023290463,0.013998507,-0.0013043622,-0.09645415,0.0534776,0.008382457,0.05481269,-0.0203928,0.0508778,0.05831368,0.015650155,0.014532945,0.013658258,-0.0104477415,0.07241976,0.041674398,0.021814106,0.051555756,0.03516462,0.0006369661,-0.01885796,-0.0522506,-0.011309166,-0.011893998,0.030702768,0.010806269,0.025386773,0.08332988,-0.09488308,-0.0355443,0.004736491,-0.049776115,-2.8716258e-33,0.05701916,-0.068377614,0.002753321,-0.05723458,-0.0058135865,0.08563788,0.02478708,-0.038551237,0.011901314,-0.04000805,0.0898369,-0.04717752,0.036167517,-0.031651348,-0.0025076794,0.012943006,-0.013288997,-0.0017709569,-0.07172361,0.022242786,0.03409281,0.038265456,0.046891507,0.052598275,-0.0105843805,-0.005340245,0.062047824,-0.021540994,0.048991762,0.08235462,0.04881915,-0.0024327054,-0.0039646416,-0.03171297,-0.025407735,0.07088586,-0.04394152,-0.008048829,-0.027767427,0.024560293,0.04027161,-0.116928674,-0.047766212,0.025768861,0.008680856,0.082354605,-0.07932816,0.014684155,0.035797466,-0.0013315489,0.016959982,-0.03130066,-0.09452346,-0.01725886,0.016635684,0.0138046425,-0.04003697,-0.050225046,0.02627976,-0.06367229,-0.006671463,0.0021065273,-0.006848702,0.044246394,0.017875707,0.015022848,-0.11527456,0.13716038,-0.013007048,-0.0208177,0.1068424,0.013877305,0.019011097,-0.03820169,0.0098211905,-0.017107865,0.06440676,-0.057151202,-0.022450248,-0.0032924728,-0.03687618,-0.030503988,-0.01602419,-0.107239805,-0.033491224,-0.04955521,0.013934875,0.1141908,-0.052761476,0.0432401,0.035804775,-0.021620067,-0.023428258,0.062657475,0.084759444,-5.676551e-08,-0.017298618,-0.07604476,0.039576795,-0.013943823,-0.03271835,-0.0072574806,0.056892704,0.041887715,0.06880795,-0.04038417,-0.041464467,0.061947,-0.032516435,-0.076984376,0.02314873,-0.0025362466,-0.07628503,0.02772747,-0.013520149,-0.025761874,-0.033150647,-0.03284515,-0.039860692,-0.042931505,0.0026394401,-0.06783969,-0.012163159,-0.06636598,-0.106382005,-0.046306085,-0.0029793754,0.045675382,0.030208595,0.010918519,0.03619164,-0.00045842436,0.038135227,-0.017967101,-0.10084025,0.0004482282,0.02430831,0.011211174,-0.15149485,0.0041748504,-0.024376914,0.0010232176,0.013780009,0.11867504,-0.01880117,-0.027337935,0.040431608,0.008085857,-0.051192164,-0.064945266,-0.071549356,-0.009861639,0.02009248,-0.065839715,-0.08510369,-0.054306906,-0.02088755,-0.030298341,0.21947917,-0.011805891 +4.3.1.27,"A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Delftia sp. HT23, also has activity against L-threo-3-hydroxyaspartate, L-erythro-3-hydroxyaspartate, and D-serine. Different from EC 4.3.1.20, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.16, threo-3-hydroxy-L-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Co2+ or Ni2+.",384,0.99999994,-0.046057943,-0.097025596,-0.054557428,-0.092323154,0.10976849,0.024781305,0.024124676,0.025561135,0.056743294,0.032991596,0.00069426035,-0.04214527,-0.067142785,0.007857819,0.029847242,0.033053268,-0.029689554,-0.0044111013,-0.007822617,-0.026532585,0.11295806,0.06928856,-0.030033123,0.016217478,0.02036768,0.046701424,0.0568898,0.012179509,-0.02696951,-0.071368605,-0.07147289,-0.0061819763,0.05018963,-0.09936616,0.04777855,0.09938106,-0.09360646,-0.08658504,0.02791368,-0.009529331,0.058017634,-0.01678121,0.015743963,-0.0032322698,-0.13023137,-0.016358554,0.06993752,0.06121416,0.04436306,-0.027185151,-0.03825194,-0.0037070285,0.013263825,0.029056884,-0.040722944,-0.045460753,0.0011265508,-0.028805973,-0.077059045,-0.0370627,-0.009801493,0.03276324,0.08235804,-0.014992919,0.10297712,-0.069920115,0.008743971,-0.08438696,0.018646792,-0.056071673,-0.06160592,-0.03301122,0.05139929,0.02839619,-0.029833475,0.11103845,0.009809404,-0.0029887133,-0.02986659,-0.01268702,0.015273086,0.056657586,0.08753854,0.06251912,0.032993946,0.0014113965,-0.0782196,0.019034741,0.035681397,-0.011100859,0.028851025,0.012927163,-0.0009006091,0.031039288,-0.006992473,0.037323404,0.016121905,-0.019143285,0.008838841,0.0006480497,-0.052555367,0.08229733,-0.06418084,-0.046976503,-0.09551022,0.00432851,-0.012107398,0.084048904,0.07128031,0.025146633,-0.011791453,-0.067923754,0.022676172,0.07808831,-0.048594154,0.029024335,0.09221663,-0.06401454,-0.046772506,0.020894853,0.01359912,-0.055609662,0.024329403,0.054192726,-0.04074594,0.03401297,-0.11260068,2.814979e-33,0.055266693,0.03171979,-0.02205099,-0.017588811,0.05190373,0.050384853,-0.08063487,0.007873479,-0.020628005,0.0025075139,-0.11395062,-0.036140546,0.069419764,-0.032878254,-0.09447853,-0.013912211,-0.06497313,0.05868713,0.046423193,-0.007887488,0.054533575,0.052838385,-0.031591598,0.037050184,-0.0395903,0.07086857,0.035686523,0.011454038,0.052482348,-0.01354028,0.01244728,-0.13035469,-0.09785305,-0.039696135,0.06277631,-0.02837655,-0.10662798,0.0077574323,-0.07227555,0.017027508,-0.013120152,0.023222776,-0.035252567,-0.03552433,-0.0064544408,-0.11681752,-0.013550743,0.057697054,0.0030671814,0.03117996,0.021218551,-0.026070407,0.03806535,-0.07542247,-0.09474109,-0.03596244,0.014616293,0.06340493,0.07799493,0.04253232,-0.015152656,0.074511275,-0.011565514,0.010579809,-0.0039409124,-0.018760813,-0.009372417,-0.030344855,0.07822612,0.08959307,-0.010799905,0.009581903,0.044707183,0.03813991,-0.00089516165,-0.0715351,-0.085192755,0.035632312,0.045640364,0.038935,0.03594831,-0.07907839,0.028089868,0.023624167,-0.06772546,-0.007396416,-0.06559413,0.01953959,0.007952438,0.0052321833,0.06542395,-0.06191816,-0.058146887,0.0052894624,-0.006826945,-3.4354234e-33,0.08471717,-0.04340907,0.07410834,-0.08819744,-0.049316138,0.022612536,-0.03912448,0.042108323,0.010187321,-2.0095902e-05,0.13594268,0.00829429,-0.008525774,-0.036604498,0.021401241,-0.014291291,0.014105215,-0.0002472375,-0.040658936,-0.01100291,0.008784172,0.022822762,-0.04366326,0.012360639,0.008532176,0.01980746,0.0055494993,0.0009703199,-0.031421464,0.044911325,0.017148344,-0.017745303,-0.031777106,-0.07078022,-0.057474636,-0.04084463,-0.094050184,-0.024661053,0.034181155,-0.047359012,0.0778828,0.028562518,0.089556254,0.05043559,-0.0047806683,0.06606213,-0.09263622,-0.008740841,0.06540248,0.046343155,0.016150244,-0.017699314,-0.006890389,-0.063826926,0.025566047,0.007754706,0.035235878,0.008609862,-0.05183913,0.02438901,-0.03916259,-0.04837604,0.014652277,0.046188317,0.04046219,0.031125266,-0.02326886,0.058390904,0.111734875,0.025463406,0.058125757,0.05718161,0.05260993,0.052973244,-0.04817802,-0.036776632,-0.026769683,0.025745688,0.061235256,-0.011067579,0.028378755,-0.07727818,-0.05026734,-0.08935204,0.073785536,-0.024728535,0.004296003,0.0687824,-0.040299788,0.018619318,0.010691298,-0.07059424,-0.03304661,0.017554233,0.09049512,-5.102936e-08,0.051518653,-0.0726594,0.013395369,-0.01739043,-0.022801545,0.015004282,0.045548905,0.06859116,0.07331957,-0.015782002,0.051338103,-0.0028629357,-0.025165644,-0.02005175,0.10285077,-0.009725961,0.017742716,0.070561305,-0.016305467,-0.028220484,-0.037668627,-0.0017614135,-0.07078399,0.03138923,0.102982864,-0.026039429,-0.0055396017,-0.009070476,-0.013006626,-0.022760144,-0.026640227,-0.009050332,0.00769812,0.010620742,-0.050781842,0.046330933,-0.07312698,-0.017273767,-0.054584835,0.033151213,-0.012527597,0.09581644,-0.067186,-0.049176652,0.006890486,0.018601852,-0.058179628,0.054587044,-0.09768902,-0.086530134,0.043996107,-0.031482004,0.012293857,-0.0050301105,-0.1255439,0.084741876,0.013551553,-0.086134985,-0.023497496,-0.026614856,0.065421686,-0.018274268,0.14690687,-0.025629163 +6.3.2.36,"The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 [pantoate---beta-alanine ligase] and EC 2.7.1.33 [pantothenate kinase], respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine. The two archaeal enzymes that catalyse this conversion are EC 2.7.1.169, pantoate kinase, and this enzyme.",384,1.0,0.011341468,-0.011908654,-0.07034321,-0.036790337,0.0844553,0.086015396,-0.047511343,0.029549347,0.07530403,0.02574739,-0.03917763,-0.010078984,-0.027010994,0.029187268,-0.038580038,0.020184621,-0.10405815,0.033769235,-0.014935332,-0.04678845,0.045147434,0.039878014,-0.07125274,0.027849147,0.03468286,-0.0122198695,0.040801827,-0.08309565,-0.055001557,-0.02054322,-0.016556745,-0.057703137,0.02781012,-0.013147164,0.0023329407,0.074965335,-0.004538975,-0.0907614,0.05740817,-0.052481953,0.11541392,0.045168985,0.06510141,0.0042425613,-0.039205868,0.087577105,-0.018811556,-0.0056852684,0.046154432,-0.035190053,-0.075964436,-0.044026546,-0.06271306,0.040095005,0.028906327,0.14442852,-0.08148172,-0.065221235,-0.0077652126,-0.019540431,-0.0046869735,-0.041556176,-0.016483607,0.045667388,-0.005636448,-0.016073981,0.07650894,-0.031977553,0.058076248,0.014395748,-0.09464444,-0.021288255,0.033262625,0.05593778,0.037679978,0.061201867,-0.017863661,0.003551937,-0.030545574,-0.056085166,0.017939974,0.01779073,0.0010511639,-0.0127399145,0.0097629875,-0.03812985,0.017366793,-0.0036883554,0.056463674,0.028267806,0.07364319,-0.016578281,0.08753728,-0.06662368,-0.07917996,0.019268876,0.044854224,-0.041230254,0.04583984,-0.016093453,0.02248415,0.064289175,-0.0034520174,-0.052642953,-0.04126,-0.0021792804,-0.021086568,0.12312328,-0.0049248217,0.07410829,0.054998346,-0.020991465,0.12795195,-0.006315318,-0.046844266,0.12327928,-0.003732622,-0.08450896,-0.032797936,0.037003405,-0.025615579,-0.035360176,0.07634976,0.019276457,-0.068665005,0.0308525,-0.14445645,2.7948006e-33,0.060420834,0.04917306,0.088385776,0.007439582,-0.015265642,-0.027252479,-0.080173224,-0.02156781,0.02365773,-0.071589775,-0.06499402,-0.08596299,0.0382981,-0.022262275,-0.0071589993,0.0022213159,0.012020736,0.02555959,0.03071407,0.06264541,-0.06962895,0.06091994,-0.020540439,0.008771278,0.07619419,-0.019463757,0.03413495,-0.03517118,-0.0059388704,0.017971737,0.012582589,-0.02754686,-0.066691734,0.060289044,0.039846458,-0.038254496,-0.05683954,-0.04892748,-0.02278261,0.07099138,-0.011038235,0.011541015,-0.071050294,0.0153974565,0.07463435,-0.10007506,-0.027540509,0.11202766,0.0124564245,0.06144714,-0.031887587,-0.012184663,0.089416854,0.05491693,-0.051686063,-0.0077400403,-0.051310252,-0.043691326,0.09651891,-0.010230936,0.031430252,0.05499106,-0.051982384,0.022412999,0.023581283,0.029727159,-0.074584045,-0.07268112,-0.063403234,0.07250892,-0.0029369385,-0.06512708,0.0010067067,0.08202261,0.026326312,-0.07698694,-0.03641709,-0.054576665,-0.03646338,0.0027537157,0.046829227,0.055251542,0.043090552,0.026515303,-0.024717879,-0.037353855,0.04207955,0.038335096,0.005032469,0.01128234,0.105641775,-0.0468709,0.015602622,0.055978596,-0.031525068,-2.5518083e-33,0.086486876,-0.10425902,-0.009401992,-0.021273697,-0.047291268,0.03277894,0.0098688,-0.075032026,0.012566105,-0.065086246,0.09646981,0.03044896,0.03863723,-0.08464331,0.01596253,-0.09891375,0.039092578,0.040885482,0.0036789153,0.037979674,0.036634974,-0.0046246992,0.015695494,-0.024547186,0.04781482,-0.014517585,0.007084802,0.12445857,-0.017979493,0.072558306,0.0043154913,0.05197267,-0.032659274,-0.030796275,-0.10388484,0.0069321045,-0.045433056,-0.026028922,-0.013178118,0.018724028,0.0029008854,0.060781717,0.023800308,-0.021926817,0.03824332,-0.009577228,-0.0697142,0.03169831,0.061327986,-0.0690818,-0.026949773,-0.023267053,-0.002673844,-0.02302338,0.013454759,0.012201256,-0.0012589635,0.044184055,0.050362494,-0.04409442,-0.06492417,-0.08905298,0.08367605,-0.023634601,0.070118666,0.03767346,-0.050410945,0.10203964,-0.026838398,0.019102354,-0.033657715,0.04304123,0.06004653,0.05313469,0.030619299,-0.030818898,-0.06177061,-0.05889106,-0.013190811,-0.05405223,-0.09028836,0.004560077,0.043672074,-0.07466939,-0.07667397,-0.031011311,0.047551837,0.046994157,-0.07310199,0.029924693,-0.03342018,-0.09122666,-0.010771796,0.048513725,0.047060855,-4.331767e-08,0.056795273,-0.032936677,0.027109938,-0.035897188,-0.021200402,0.04618382,0.0652751,0.016973922,0.032519694,-0.05433269,-0.067239694,0.044536505,0.0638547,0.011246798,0.0051768455,0.08220248,-0.03604674,0.006357132,-0.05236865,-0.0224712,-0.03986262,-0.055146556,-0.06257281,0.031163469,0.068035014,-0.020756703,0.05997478,0.10601538,-0.04862517,-0.07599666,-0.06314071,-0.023977388,0.04705339,-0.02362064,-0.07174131,0.006768983,-0.029673534,0.009816327,-0.012795354,-0.0015527529,0.024613256,0.013604747,-0.09479112,0.04840384,0.048907053,-0.0020258143,0.06038796,0.04497968,-0.06075755,-0.062191375,0.05650689,-0.00038139476,-0.0068921116,-0.05796314,-0.054771725,-0.03899346,0.014024931,-0.05778499,-0.016542971,-0.0024068488,0.021347899,-0.023407724,0.11089391,-0.053148653 +1.1.1.310,"This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 1.1.1.338, (2R)-3-sulfolactate dehydrogenase (NADP+), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24, (2R)-sulfolactate sulfo-lyase. +The enzyme is specific for NAD+. 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+1.1.1.311,The enzyme is involved in degradation of ethylbenzene. ,384,0.99999994,-0.043861218,0.0090457965,-0.003935259,-0.016591484,0.10585135,0.0060275095,-0.028735464,0.1187544,0.009369628,-0.015759666,-0.032700393,-0.026713833,-0.055190556,0.016044112,-0.080798164,0.08466242,-0.051156547,0.026082193,-0.056560464,-0.038775086,0.036967695,-0.019925708,-0.0046349126,-0.017888838,0.034289617,-0.026539546,0.061466776,-0.021699348,0.012424207,-0.06720203,0.060332887,-0.0055080405,-0.0050109327,0.03270949,0.017009286,0.051207025,0.019901428,-0.10909039,-0.0070555327,-0.03087648,0.03361826,0.02005541,-0.13259988,-0.06871529,-0.0018393297,-0.031997744,-0.027947528,-0.029324953,-0.02579779,-0.05182098,0.023924692,-0.0656259,-0.0050687115,-0.015407452,0.007383204,-0.057021998,0.040154617,0.0061331335,-0.110675626,0.0797813,0.08642732,-0.0307456,-0.062249746,0.03663856,-0.004853105,-0.02704489,0.11894584,-0.0091363285,0.0104906745,0.033143833,-0.07901783,-0.12141297,-0.032730725,0.038386222,0.004429032,-0.058503248,0.062081706,-0.06876516,-0.012927705,-0.053174607,-0.010267386,0.03149378,0.05950564,-0.0075174775,0.06886964,0.048194595,-0.017197758,-0.02009068,0.06505054,0.07160695,-0.02398971,0.028058847,-0.011813056,0.0023067691,0.008869761,0.07445723,0.03519558,0.0015890542,0.033488702,-0.00039487344,-0.012764634,0.1063572,-0.09043873,-0.11239587,-0.03838012,0.022491291,0.071068116,0.05614563,-0.016471801,0.011785417,-0.01581164,-0.03248017,0.015752953,0.04507425,-0.051315717,0.05125339,0.06408246,0.00051995437,-0.049663242,0.011656347,-0.040198445,0.0055896128,0.003076575,0.026394647,-0.051828004,0.027077623,-0.003116127,-3.1218577e-33,-0.01058475,-0.015145413,-0.07574031,-0.04781489,0.04623396,0.011912257,-0.022483457,0.08849968,-0.0591349,-0.048272222,-0.037746146,-0.08962445,-0.020988256,-0.056973115,0.031973887,0.032072794,0.018695073,0.08242128,0.01740014,-0.03845342,-0.014169834,-0.039571527,-0.05569541,-0.0051140427,0.0038234217,0.056359235,0.04680353,0.07310225,-0.0174478,-0.05459219,-0.032170136,-0.052518602,-0.1179914,0.0088616125,0.04470803,0.062629655,0.019287515,0.06405108,0.04136688,0.07574404,0.04322614,0.0020192238,-0.004374012,-0.0204281,0.037910726,-0.013246929,-0.087943226,0.060278144,0.023951879,-0.011052194,-0.008787102,-0.04469361,0.10182692,0.01736242,-0.02560688,0.057200313,-0.0070807277,-0.041145436,0.010808434,-0.05206064,-0.024557915,0.011435308,-0.066371076,0.027175816,0.06052775,-0.010741201,-0.0830255,0.019055068,-0.052745577,0.014460352,-0.09582761,-0.0423312,0.045494143,0.0011018831,0.07696704,-0.068798624,-0.10326786,-0.020757927,0.02659487,0.034821555,-0.011405075,-0.004531342,-0.023451205,-0.07355949,-0.047095537,-0.029292738,-0.0022422688,0.0037189643,0.025928758,0.028351326,0.12438573,-0.12594864,-0.0155744925,0.026629385,-0.013002887,1.2637796e-33,0.075390205,0.008791774,0.014035487,-0.01873593,-0.0066660587,0.016474314,-0.023961905,0.051962398,-0.03240633,-0.01849534,0.04514507,-0.056625426,0.01282822,-0.0013012337,-0.017640684,0.06691969,-0.019733887,0.035427894,-0.016371619,-0.06992095,-0.063678525,0.06673153,0.027066786,0.052876607,-0.009656523,0.04600035,-0.0013940005,0.05081836,0.04613223,0.015771382,-0.025849061,-0.051625542,-0.038287345,0.051346887,-0.014865909,0.10937607,-0.02013799,-0.023433998,0.025315193,0.03446942,-0.0081424555,0.055520676,-0.017943386,0.015500871,0.06867916,0.09856507,-0.09425327,-0.012089586,-0.025350345,-0.08694371,0.08931862,0.044962686,-0.010138319,0.037459265,-0.033487957,0.038141012,0.023144642,0.002344711,-0.027730748,0.0045980765,0.034187447,-0.0071152532,0.010756993,0.08094495,0.0050279917,0.021366801,-0.045470487,0.14222719,0.005085853,-0.009997991,0.11715235,0.04862019,-0.016010525,0.03859532,-0.06566589,-0.04561918,-0.013248002,-0.06428432,-0.06553273,-0.10146018,0.026728017,0.0014070402,-0.015415925,-0.05329394,-0.09675124,-0.04662347,-0.012171936,0.07907266,-0.0049494742,-0.012648436,-0.0063639027,-0.018273799,-0.09682714,0.110789746,0.094005935,-1.9593585e-08,0.042380482,-0.05359293,0.0378347,-0.032485228,-4.5775218e-05,-0.035616845,0.06354096,0.08061411,0.068827435,0.0041213525,-0.12425155,0.054647185,-0.015230016,0.06807148,0.040232476,0.010101585,-0.031948656,0.03135521,0.022044675,-0.019865926,-0.053881887,0.015785549,-0.08323397,0.04559447,0.008798458,-0.014060333,0.041244745,0.12315776,0.03967946,-0.021854023,-0.02636257,0.088969946,0.047218267,0.057940084,-0.041671593,0.02255046,-0.0015524974,-0.042799033,-0.042702597,0.03529104,-0.016308002,0.012227462,-0.08185837,-0.028967593,0.047218315,-0.009993052,0.07493785,0.0034915258,0.034956284,-0.04685285,0.065616794,-0.009527234,-0.03736239,-0.0490037,-0.12519008,-0.022413578,-0.05490692,-0.0028722337,-0.0068852524,-0.08736241,0.014267072,-0.041869715,0.19263788,-0.049432147 +1.1.98.2,"The enzyme is very specific for D-glucose 6-phosphate. No activity with NAD+, NADP+, FAD and FMN [1].",384,1.0,-0.061972275,-0.072112896,-0.0884643,-0.04963709,0.01753227,0.030198034,-0.07026592,0.033855647,0.003648924,0.04119767,-0.056249674,0.07312065,-0.12525788,0.08460046,-0.035466086,0.023703093,-0.031523913,-0.025461461,0.020579642,0.018556844,0.04721363,0.009127675,0.08024265,-0.062262233,0.09706635,-0.029460542,0.056012914,0.023796363,0.004359555,-0.021419596,-0.055094875,0.04308048,-0.004163111,0.0053564636,-0.0005149144,0.10974856,0.0008741251,0.023923913,-0.03815087,-0.019229474,0.033908263,-0.023617089,-0.010382498,-0.04698201,-0.017168758,-0.06620431,-0.064888656,0.04457268,0.030319298,0.04036047,-0.03413759,-0.06256369,-0.014854521,0.018787092,0.06477104,0.010998563,-0.032378186,-0.003250923,-0.057800263,-0.009660329,-0.025160244,-0.029132811,-0.002908723,0.022747556,0.11102118,-0.03314302,-0.012043659,-0.029195452,-0.056686208,-0.04269615,-0.08416298,-0.048742373,0.021131411,-0.050978426,-0.009452453,0.0131310895,-0.094257444,-0.056277424,0.06550953,-0.041507535,0.055576112,0.032315414,0.03350455,0.08787489,0.029523341,0.00749625,0.0033995397,0.052850995,0.00937291,0.027523475,0.006815903,0.0027492829,-0.074019276,-0.030137353,-0.13833715,0.010044904,-0.009855532,0.008832983,-0.016721796,-0.006242027,0.057857934,0.09865507,-0.028742211,-0.02748844,-0.057725813,0.025953693,-0.0338131,0.10791248,-0.048636783,-0.034582295,-0.026128422,0.054896235,0.06203016,-0.00456896,-0.10462081,0.05049486,-0.0391154,-0.0964107,-0.054149896,0.00992623,-0.029733472,0.0058024027,0.047784265,0.08771982,0.004160103,0.04526799,-0.08572126,-1.3941591e-33,0.068725936,-0.01860794,-0.007648782,-0.035616934,0.008873503,0.037410714,-0.02413097,0.02774348,-0.015626404,-0.019947873,-0.04838425,-0.03382216,0.06773043,-0.038796835,0.03261709,0.030709472,0.031071464,-0.05999718,0.0652542,-0.027362715,0.15313657,0.03817955,-0.0033409125,0.043078866,0.0286484,0.066061914,-0.05436529,0.13331892,-0.0061062058,-0.006648231,-0.0052752676,-0.10465729,-0.040920757,0.00702825,0.0543479,0.018898688,-0.10927307,-0.016003642,-0.030673906,0.034488704,0.008637305,0.016176026,-0.017966554,-0.036691096,0.0040070657,-0.064980514,0.031842668,0.0663725,0.015882907,0.12374668,0.063265525,-0.062004615,0.05314675,-0.060676314,-0.034488752,0.04982666,-0.05345746,0.016918665,0.02730179,0.046186224,0.001623852,-0.028825589,-0.031787664,0.06580346,-0.025335612,0.0053750225,-0.07501261,-0.05498901,0.002709887,0.11670764,-0.00030831507,0.02806239,0.086172394,0.034235895,0.041109715,-0.028195092,0.03810834,-0.015791392,0.00016164265,-0.008131776,0.0815362,-0.046830103,-0.038134336,-0.060260817,-0.06829542,0.016728539,-0.029924229,-0.069361314,-0.05667225,0.019510591,0.06815247,-0.058660798,-0.07485262,-0.02016163,0.064766884,-8.950018e-34,0.04134989,-0.028226184,0.105846375,-0.099216245,-0.035863757,0.10635361,0.060541406,-0.09239747,0.05283951,-0.04843985,0.05188449,0.033390317,-0.024587363,-0.045257103,-0.025505539,0.038487263,-0.10325946,0.0071915165,0.026842274,0.045210924,-0.079208784,0.15135355,-0.016665293,0.033652786,0.05811845,-0.012765738,0.011069178,0.05035403,0.038747326,0.031731304,0.03696083,0.021990295,-0.06502925,-0.032109946,-0.0026042317,0.014459674,-0.04807038,-0.01896435,-0.042103864,0.019512799,0.023076728,0.060580812,0.0014540938,0.0319399,0.01683858,0.029076682,-0.096769825,-0.02070231,-0.0027473418,-0.055415954,0.018881539,-0.008079858,-0.022529943,-0.0074628606,0.10278351,0.037568334,0.053804565,0.009507529,-0.009496285,-0.005661434,-0.0009294435,-0.050528828,0.009622713,-0.038469695,0.05731728,0.04981633,0.021284152,0.067811355,0.033269558,0.037186388,0.07948038,0.02920774,0.010301808,-0.004118267,-0.032287404,-0.0031071508,-0.06515687,0.058941666,0.0038095985,0.005254576,0.015198606,0.04572805,-0.092281014,-0.03973903,-0.034280717,0.00078084774,0.040388487,0.057967227,-0.00912655,0.040721353,-0.0074950266,0.071491085,0.005219282,-0.03180256,0.035987046,-2.6738697e-08,0.08426224,-0.07327258,0.0253477,-0.07109252,0.035336137,-0.012181213,0.030488515,-0.0013031913,-0.025510265,0.034501556,-0.048056774,0.12080972,-0.0031023403,-0.028613484,0.04670154,-0.09100291,-0.03253039,0.027891539,-0.0859396,-0.0214195,-0.06891035,0.043898746,-0.122678675,0.042319108,0.035906505,-0.045776516,0.03759578,-0.03342562,0.03422186,-0.025172073,0.005890531,0.017529214,0.024491942,-0.06588553,-0.10652413,0.054354586,0.028980447,-0.021655837,-0.105762735,0.063396476,0.018430118,-0.09495863,0.009774312,0.0031357834,-0.085732326,0.0528514,0.01707278,-0.04268664,-0.045948733,0.011377755,0.026259132,0.00097483734,-0.08994311,-0.08543159,-0.07349496,0.031169204,-0.0034861031,-0.058417782,-0.009139919,-0.071878836,0.02952174,-0.016261522,0.08983332,-0.035506185 +1.3.7.7,"Occurs in photosynthetic bacteria, cyanobacteria, green algae and gymnosperms. The enzyme catalyses trans-reduction of the D-ring of protochlorophyllide; the product has the (7S,8S)-configuration. Unlike EC 1.3.1.33 (protochlorophyllide reductase), light is not required. The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of nitrogenase (EC 1.18.6.1), which catalyses an ATP-driven reduction.",384,0.99999994,-0.06925925,0.053970408,-0.054659255,-0.00039310832,0.08959743,0.0019676918,-0.0016359682,0.012378262,0.057482265,-0.015444113,0.0045589074,-0.053370968,-0.025512079,0.014492495,-0.018263862,0.05534501,-0.086461015,0.04010095,-0.018825276,-0.048949383,0.025768755,-0.011550073,-0.035490002,-0.03891811,-0.021450754,0.011487604,0.010726567,-0.0140153915,-0.042391635,-0.09636659,-0.014239683,-0.029050255,0.039022855,-0.047503825,0.0761482,0.07910714,0.023073895,-0.101692416,0.029318519,0.039785437,0.011617385,0.014193523,0.02250328,-0.043249294,-0.03886402,0.05534021,0.028929517,0.036209576,0.013995999,-0.106025584,-0.01753914,-0.057184566,-0.057608303,0.091617785,0.041545983,0.025971727,-0.012518391,-0.0347775,0.018438125,0.025359703,0.10079073,-0.01106634,-0.022970578,0.00861585,0.047535304,0.004458025,0.022630947,-0.08282321,0.05283025,-0.06300213,-0.03219186,-0.023708511,-0.0028888031,0.04694758,-0.015941257,0.036533047,0.07237009,-0.024839258,0.029352535,-0.0069993883,0.039141685,0.038255684,-0.00070636376,0.03773019,0.07944195,-0.017775755,-0.01833857,-0.04540559,0.007018427,-0.00964177,-0.047819223,-0.010670437,-0.023796007,-0.029896157,-0.121355556,0.08630957,-0.0042422353,-0.050181426,0.038863618,0.00021771352,0.0347748,0.056171224,-0.019459695,-0.07802527,-0.020910766,0.024804354,-0.0068956735,0.15073678,-0.0321248,0.016534789,0.039327912,0.036822516,0.028712772,0.026270175,-0.046136413,0.039069854,0.05117077,-0.03992405,-0.08998898,0.03857647,-0.001070451,-0.02064437,0.0007384362,0.044831008,-0.069994465,0.043865003,-0.17140882,1.0513663e-33,0.074403666,0.0043495093,0.055456392,-0.050337084,0.07973976,-0.06171452,-0.07511314,-0.03849599,-0.047561087,-0.088937454,-0.042464893,-0.07597732,0.07713466,-0.071084745,-0.042524703,-0.08598962,0.010876625,0.03602764,0.0009102126,0.050085213,-0.006733932,0.07797943,-0.06294979,0.054004055,0.039179124,0.10719387,-0.03313848,-0.050695237,0.09851714,-0.012793152,-0.013227684,-0.06757229,-0.090912595,0.054456092,0.083013825,-0.03742574,0.008621769,-0.03919072,-0.008201565,0.01418525,-0.10320608,0.055143725,-0.056549694,-0.02433956,0.084629335,-0.024124173,-0.013630406,0.046387997,0.0642735,0.06548424,0.036236987,-0.049946416,0.08425306,-0.042355932,-0.04547805,0.019583749,0.0025022775,0.010440143,0.030055342,0.029559948,0.020060169,0.051150627,-0.008586638,0.021394825,0.03548043,-0.009611315,-0.045686573,-0.013111488,-0.013462695,0.026216628,-0.10761022,0.008488952,0.07332205,0.0075343316,0.1149114,-0.06771004,-0.002182874,-0.058295794,-0.004473831,0.049074598,0.012997761,0.010077208,0.030128198,-0.11893858,-0.06975468,0.011479631,-0.019062707,-0.031072289,-0.006961268,-0.006588805,0.10267878,-0.024104841,-0.07007506,-0.012062556,-0.0555285,-1.0862053e-33,0.09393134,-0.082381085,0.036176275,-0.05809815,-0.037856158,0.023502845,-0.031926367,-0.044233818,-0.013941205,0.010876435,0.12898247,-0.014221381,-0.0604838,-0.017044732,-0.004152714,-0.038780402,0.026987346,0.089130044,0.003590862,0.009445652,-0.023409713,0.061473712,0.04131408,0.018174008,0.014678341,0.004006502,-0.047865257,0.06334027,0.093531094,-0.010746315,-0.029741947,-0.030294592,-0.044813134,0.005680198,0.0074655437,0.033755552,-0.05025664,0.0019657123,0.032138973,0.049360234,0.023060538,-0.04872807,-0.015021652,0.058458954,0.00898288,0.037816674,-0.08558275,0.051252015,0.0141125275,-0.018420413,0.014640267,0.0037857143,-0.07566696,0.0129935965,0.025120743,0.023928894,0.13266753,0.06954165,-0.012804244,0.07346051,0.027749939,-0.11363531,0.06960528,0.04385963,0.0786647,0.09964602,-0.02182013,0.13744518,0.0025315573,0.021440499,0.03548425,0.06638584,0.031530865,-0.005533943,0.012944299,-0.04240185,0.00020694043,-0.011634996,-0.046752267,-0.016409347,-0.03037382,0.006354503,-0.0032600246,-0.07778709,-0.00673441,-0.054608814,0.00837905,0.04093431,-0.043600474,-0.019707242,0.0012174239,-0.0024965513,0.025250254,0.045230262,0.037684318,-4.1237904e-08,0.023957085,-0.048230223,0.022371499,-0.050356645,0.04614532,0.04297259,-0.000701388,-0.0022154364,0.076908454,-0.05170582,0.01851292,0.053445626,0.061081655,-0.049533043,0.05274763,0.0042414265,-0.022190377,-0.04437043,-0.011537501,0.06462611,-0.06054603,-0.061104465,-0.15854476,0.034721527,-0.00044437833,-0.04078831,0.085624054,0.06412489,0.011910242,-0.0819283,0.026108652,0.019859707,-0.012930069,0.008334609,-0.070208184,-0.010757238,-0.06120156,-0.0010095095,-0.0663766,0.04858819,-0.026636362,-0.008920125,-0.059296977,0.037663843,0.00020021241,0.051094588,0.00033493608,0.027968938,-0.02930785,0.07478819,0.010177053,-0.011188147,0.016187571,-0.06015873,-0.15219305,0.017004875,0.019731993,-0.039306983,-0.039921932,-0.0040057683,0.013511767,-0.07285273,0.15009366,0.040349036 +1.5.3.18,The enzyme is involved in pipecolic acid biosynthesis. A flavoprotein (FAD). 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+1.6.5.8,"An iron-sulfur flavoprotein, containing two covalently bound molecules of FMN, one noncovalently bound FAD, one riboflavin, and one [2Fe-2S] cluster.",384,1.0,-0.03176028,-0.061815143,-0.14066793,0.111762516,0.07521011,0.03372819,0.009866394,0.06536478,0.024572685,-0.113237396,-0.004414715,0.020042194,-0.08014244,0.010003927,-0.09372741,0.0031193923,-0.033034403,-0.008293188,-0.039319165,0.032185897,-0.05567468,-0.0043880413,0.05776936,-0.047469035,-0.07309507,0.03366343,0.026411586,-0.016894013,-0.0038979908,-0.021469098,0.05763633,0.047944557,0.040799182,0.0315018,-0.04636379,0.04641818,0.07091367,-0.049381558,-0.035918184,-0.039755937,0.023750558,-0.011413228,0.012031225,-0.027336847,0.074013226,-0.024807354,-0.040922552,0.08693084,-0.019238314,0.06255046,-0.052140366,-0.036206722,-0.09059608,0.08858173,0.06247657,0.033599213,-0.020639189,-0.08754607,-0.031336434,0.054612983,0.023167474,-0.031018099,0.025772348,-0.021115033,0.060978916,-0.015054605,0.012365244,-0.034913093,0.046532366,0.0096184295,0.017042734,0.056253735,-0.11714727,0.026727812,0.015760459,0.10673589,-0.016278718,-0.008472286,0.09411168,-0.0575627,0.0038633132,-0.022747083,0.08042532,0.10545004,0.023470946,-0.057634756,-0.042834807,-0.006457145,-0.011188127,0.073231235,-0.034958746,0.058993567,0.06382199,-0.0061414447,-0.06224162,0.040639527,0.041538853,0.051512245,-0.07984328,0.06578048,-0.048563853,0.0038504219,0.000296038,-0.038481865,-0.05284591,-0.059362646,-0.029965684,0.041111857,0.014049257,-0.014647399,0.0245968,-0.034658466,0.013098223,-0.11466247,0.017066753,0.021820774,0.014768021,0.009140671,0.027240708,0.029033959,-0.010115579,0.11849736,-0.0060060886,0.07624068,0.03486097,-0.05040864,-0.14399219,1.9032497e-33,0.06935518,0.032507975,0.053780645,0.03169151,-0.033199612,-0.035699908,-0.07869493,-0.012697408,-0.0017895494,0.041711982,-0.110744946,0.01994612,0.054945573,-0.08815957,0.054046735,-0.07534357,-0.016554844,-0.052549582,0.104867324,-0.075767614,0.029585054,0.09382798,0.031723134,0.00568678,0.014911242,-0.011239872,-0.04014862,-0.016436106,-0.0034838305,0.019909654,-0.0021397222,-0.050485387,-0.049076024,0.005996855,0.022717316,-0.03919088,-0.065872476,-0.08833924,-0.10265835,0.032262444,0.02371885,-0.025354758,-0.023253022,-0.022748621,0.0463699,-0.05791373,-0.07490986,0.054389752,-0.022700034,0.048454523,0.00068849995,-0.021196801,0.049332976,0.08837629,-0.08575753,-0.006246864,0.008393223,0.033107743,0.052442323,0.025342718,-0.010528012,0.0051301084,0.025961632,0.026465254,-0.039651718,0.014816506,-0.035523783,-0.019767398,0.04318362,0.047956273,0.070495784,0.020258445,0.096384384,-0.008432964,0.011857156,-0.018798009,-0.027621083,-0.0565974,-0.007754677,0.054702815,-0.05307206,-0.06615845,-0.03649037,-0.013273895,-0.09385139,0.021406524,-0.020923393,-0.055871803,-0.021100163,-0.06577262,-0.03339054,0.0084483875,0.0014454387,-0.06476021,0.02623675,-2.4608827e-33,-0.019963967,-0.103591666,-0.03998452,0.023227513,-0.015907561,0.009184667,-0.017441215,-0.057425674,-0.035380255,0.030938111,0.09170183,-0.08658911,0.016077219,-0.06321641,0.020961376,0.07737045,-0.008789445,0.047240335,0.10939745,0.040643588,-0.079956196,-0.016673377,0.041797128,0.1284304,0.01848468,0.020657968,0.07747584,-0.06148048,0.009875554,0.111734085,-0.03400049,0.0018863906,-0.040804207,-0.0747951,-0.009708699,-0.011839929,0.03749269,-0.029830331,0.007874009,-0.011233536,-0.02368926,0.017746994,0.033270754,0.11170428,0.0682247,0.07164014,-0.002055321,0.048447154,0.04264048,-0.016874785,0.01499127,-0.012155832,-0.034546994,0.089871526,0.0039276495,0.029142069,0.037395343,0.07280636,0.021926498,0.06471055,-0.0063511045,-0.1059836,0.019808877,-0.025339117,0.07426553,0.035067666,0.023712635,0.070192724,-0.008340235,-0.03163161,0.06539681,-0.018070817,0.06570774,0.020190723,0.030762978,0.001779349,0.057622455,0.08225559,-0.05280388,0.033886224,0.032186102,-0.029093368,-0.006563812,0.0006761831,0.014066657,-0.13778104,0.0349344,0.08083258,-0.027033981,0.028980957,-0.014235064,0.07650991,-0.024657132,-0.06778629,-0.015445295,-2.995172e-08,0.010745352,-0.061591413,-0.009747081,-0.018373275,0.085493855,0.0021982046,-0.025067609,-0.04579764,-0.08794209,0.03645855,-0.0054739285,0.10410902,-0.062938705,-0.030606631,0.036075164,-0.026622236,-0.03730283,0.04447974,-0.03626045,-0.0170541,-0.014497228,0.038085766,-0.042955037,-0.06723034,-0.058381293,-0.060318746,-0.037121214,-0.10479589,0.08029084,-0.04122297,0.02236781,0.07990853,0.010567261,-0.054408554,-0.13675854,-0.0005717636,0.018756233,-0.022272239,-0.06610877,0.049761944,-0.09629823,0.016347956,-0.021742469,-0.008143787,-0.00863121,-0.033163432,0.037370663,0.040470984,-0.041243937,-0.004472403,0.0156076,0.04799016,0.013441601,-0.006197677,-0.03935988,0.0138493525,0.016311333,-0.041968487,0.034022465,-0.03834114,-0.031957455,-0.04834223,0.04763986,0.014490113 +1.11.1.20,"The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.",384,1.0,-0.040989634,0.020890804,-0.045709454,-0.044793535,0.114589185,-0.014459681,-0.087448925,0.12568808,0.016707389,0.013839546,-0.012312437,-0.027641792,-0.11454987,0.034994226,-0.00016778971,0.072086476,0.04674817,0.05526124,0.022686303,-0.09916627,0.035616238,-0.03811571,0.016446361,0.008476452,0.025949413,0.0055803317,0.049843907,0.06031113,0.025559023,-0.050434325,-0.009961462,-0.11383054,-0.018839767,0.019634688,-0.041498177,0.1074268,-0.07263886,-0.008832673,-0.049207516,-0.0649341,0.01170457,0.0017744697,-0.09376474,-0.05267216,-0.029853284,-0.0096232155,-0.005099137,0.043257203,-0.0006170636,0.028283458,-0.039339162,-0.012736777,0.00026696574,0.06002624,-0.007622425,-0.018782407,-0.018980892,0.0071430556,-0.041490164,0.03593367,-0.0010367772,-0.018712852,-0.041497525,-0.0088943895,0.044173002,-0.016695125,-0.019948123,0.038988728,-0.06791594,0.003756733,-0.027729731,-0.017826373,0.04827662,0.00553307,0.0622982,0.009901109,-0.050374035,-0.08868321,0.03991044,-0.062078733,0.09287829,0.074989714,0.052537993,0.17312293,0.072619215,0.0155678205,-0.0054395515,-0.033912275,-0.037789755,-0.010392054,0.027049923,0.054952383,-0.018739546,0.014497894,-0.034877177,0.03452512,0.0057937237,0.045542054,0.014119059,-0.005259135,-0.04893743,0.031995106,-0.115980774,-0.16244999,-0.08406222,0.015276601,-0.013097059,0.07174091,0.08264731,-0.0037345195,0.016811097,0.012082595,-0.008182584,0.028544862,-0.037410405,0.04694857,0.048770007,-0.013369437,-0.028302733,-0.03948298,0.024753258,0.032928977,0.061491527,0.052300293,-0.049074277,0.0038608592,-0.056169353,8.26442e-33,0.02031788,0.03211074,-0.06999484,-0.012345934,-0.008804346,0.014685019,-0.07691693,-0.008710358,-0.041122146,0.009305115,-0.075972475,-0.08514585,-0.060233504,0.00796186,0.06623306,-0.13066763,0.05114839,0.06425422,0.028583784,-0.03182431,0.009972907,0.07217354,-0.06563165,-0.0051374366,0.06103281,0.05419776,0.040416136,0.048792653,0.009566751,-0.018893054,-0.0075935028,-0.0987508,-0.04898691,0.016728437,0.025391495,0.025603652,-0.09951888,-0.016450124,-0.031116003,-0.017108902,-0.008576579,0.0310148,-0.024829406,-0.044889897,0.06565768,-0.108630925,0.032254573,0.061370187,0.056775723,0.0060827797,0.060284995,-0.016784241,0.07377039,-0.08348411,-0.0591134,0.021381196,-0.0057357047,0.014675665,0.08065011,0.060567945,-0.066594124,0.029317223,-0.038720347,0.039717544,0.0022584887,-0.012480471,-0.038625527,-0.040577836,-0.07065139,0.07963158,-0.023180947,0.05443702,0.12313462,0.0130108595,0.003340379,-0.04597839,-0.0069395117,-0.011189498,0.04077802,-0.06864565,0.0028013329,-0.005745685,-0.014991634,0.011730755,-0.03625448,-0.0006372801,-0.035210382,-0.04072747,0.03208057,0.07957797,0.0140304705,-0.11671228,-0.06412361,0.00020309673,0.023657093,-7.634951e-33,0.05138591,-0.05786858,0.07159259,-0.07466376,-0.039859924,0.0831072,0.034084182,-0.017093834,0.017910846,0.00018501356,0.1071765,-0.046220277,0.040345464,-0.03625504,-0.019357087,0.043034576,-0.02809885,0.000107518725,0.011076334,-0.096941784,0.054538086,0.092355266,0.016309885,0.047414135,0.04645682,0.04098974,0.017476648,0.12685476,0.083162904,0.05501703,-0.023184504,0.020066328,-0.035104003,-0.007972094,-0.02516178,0.089621,-0.042744644,-0.0024420863,-0.06511715,0.019759485,-0.025739465,0.010119496,0.04484227,0.04466249,0.012643918,0.09085347,-0.06249387,-0.021227743,0.040532324,-0.06082142,0.009420069,0.0107010435,-0.053015266,0.041755293,0.039292537,0.015682314,-0.003726835,-0.08192891,-0.02268362,-0.040031698,-0.010143392,-0.07559109,0.03016101,0.036148805,0.012513216,-0.03154697,-0.05006055,0.042542536,0.03326451,0.04263674,0.093348294,-0.01499053,0.020898588,-0.052803576,-0.01458336,-0.014700169,-0.019145314,0.033326894,0.013286649,0.034233537,0.06726797,0.017365135,-0.029040234,-0.019651923,-0.008269012,0.00019145536,0.0022179664,0.10382813,-0.0583573,0.044981834,0.0039493055,0.04452993,-0.015930902,0.007509893,0.04162699,-4.4230507e-08,0.006097308,-0.09735725,0.10724417,-0.09068603,-0.04999728,-0.074515715,0.0077057392,0.072352454,-0.017274937,-0.025175992,-0.083261885,0.08262888,-0.021701185,-0.07902848,0.02745677,-0.007544652,0.02615384,0.020983847,-0.019002039,-0.060346063,-0.050352953,-0.019797243,-0.115498014,0.0075724954,-0.033370323,-0.0025028687,0.04140353,-0.055846207,0.004657652,0.009250465,-0.021148555,0.048933957,0.0044974647,-0.041029062,-0.011089662,0.076321274,-0.03324887,0.016323222,-0.059239954,0.006883505,0.006686866,-0.05915071,-0.016996535,0.0520985,-0.0013512041,0.0010208556,0.063381,0.009243474,-0.014593338,-0.021837631,0.011700937,-0.05147411,-0.01945815,-0.07833423,-0.10102423,0.039195582,-0.023222543,-0.018443994,-0.033368524,-0.079241015,0.048412334,0.029230744,0.21552919,-0.0010217429 +1.11.2.2,"Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.",384,1.0,-0.008510701,-0.034025084,-0.10727865,-0.02361068,0.114744596,0.025257966,0.041220896,0.10653957,0.033811774,0.026425479,-0.04152685,-0.022210691,0.012552539,0.08003857,-0.009525949,0.061437294,0.0021648572,0.036487523,-0.06478782,0.03756939,0.06928724,0.0026488851,-0.031292435,0.024967378,-0.05940866,0.04981692,0.042627048,0.034826677,-0.03125136,0.020721072,0.027265074,0.04609866,0.17138165,-0.055131257,0.10677403,0.067287765,-0.027639663,-0.06831108,-0.0076024365,0.021352561,-0.00533668,0.0051692263,-0.033728298,-0.03081877,-0.026690383,-0.0051170997,0.08340344,-0.020166928,0.003302625,-0.00034642813,0.019205917,-0.0011069081,-0.0756572,0.028833726,-0.039196,-0.010580604,-0.08233789,0.0116232075,0.0044962093,-0.060864143,-0.061075516,-0.020040262,0.048121985,0.018073084,-0.011944777,-0.037371263,0.033133328,-0.043516804,0.024638617,-0.07903082,0.012231503,-0.034495533,-0.010965546,0.004250014,-0.022211915,0.040940493,0.06633233,-0.07971946,0.017788878,-0.05015792,-0.0056020953,0.00084258226,0.04675606,0.09368433,0.064877346,0.020324418,0.014715509,-0.0055315373,-0.030914627,-0.043121528,0.023946287,0.049083915,-0.018136105,-0.06836917,-0.026262263,0.030958707,-0.028170934,0.038470194,0.0011459027,-0.051406108,-0.0070872754,0.055234637,-0.10994258,-0.021425959,0.027131539,0.0071629845,0.06742468,0.09852109,0.021866387,0.036522366,0.008231266,0.013678725,0.0033561732,-0.04670025,-0.0069893,0.088729724,0.08519295,0.0021495584,-0.057948302,0.059013188,-0.047389366,-0.034002826,0.001057329,-0.011194538,-0.026895221,0.029670672,-0.05143393,5.9430247e-33,0.0017298488,0.008759756,0.05966937,-0.038439926,-0.04224281,0.0013611077,-0.06143866,-0.087625735,0.06622777,-0.10174516,-0.018975995,-0.031070909,0.032884415,0.047397055,-0.014707248,-0.037218172,-0.040798377,-0.04249795,0.08546897,0.0037992133,-0.000507244,0.03925839,0.0051167933,0.054440163,0.0066098208,0.030927256,0.020065872,-0.058344632,0.04656506,-0.0025300626,0.0033581064,-0.0095552085,-0.036210872,-0.005971803,-0.068549424,0.114530206,-0.14158434,0.08027163,-0.04716701,0.035094067,-0.06798506,0.011320063,-0.05000715,-0.0180698,0.074607365,-0.16201207,-0.11190361,0.0696648,0.049995292,0.058925375,-0.026968282,0.0033032894,0.00095207157,-0.06391216,-0.04928594,-0.020378198,0.031143982,-0.001277313,0.027802559,0.077136524,0.056167677,0.09924294,-0.09280881,0.033383727,0.08754729,0.013232713,-0.045501415,-0.042548675,-0.011111839,-0.0037825583,-0.038621064,-0.0069527845,0.06986954,0.061055467,-0.026520813,0.010121867,-0.022691078,-0.0010352047,0.06540112,0.003967842,0.057406664,0.02444224,0.082139686,-0.003918801,-0.12874344,-0.062955365,-0.011915995,-0.040017802,-0.021203138,-0.02860041,0.089414336,-0.13576101,-0.030792937,-0.05805926,-0.082454756,-6.5014396e-33,0.057995044,-0.051092193,0.03174276,-0.023511961,0.015952462,0.06207594,-0.06467118,-0.03593134,0.00088931667,-0.0043204455,0.046369117,-0.011561733,-0.0963065,-0.0670645,0.013189919,0.03436772,0.029116662,0.09600774,0.0015190961,-0.023517124,-0.0016369482,0.065450065,0.030372798,0.08092033,0.050215714,-0.035951972,-0.019927047,-0.04540741,0.10144257,0.026017824,0.02161359,0.06056579,-0.056008223,-0.029797517,0.03449559,0.01097945,-0.111778475,0.012357168,0.040208876,0.017703323,-0.018390043,-0.05878515,0.099031895,-0.0015289839,-0.018987602,0.075648434,-0.09662626,-0.008337895,0.035293177,-0.07434537,-0.03622299,0.002700271,-0.041645538,-0.050585926,0.097404726,0.012360211,-0.042522088,0.017887484,-0.005822517,-0.04655984,-0.016576808,0.05799926,-0.0052580703,0.012232387,-0.035268683,0.076820545,-0.019288706,0.0024267687,0.054880537,-0.033511393,0.041966833,0.037733763,0.02469863,-0.0668167,-0.059224032,-0.028942972,-0.021571038,0.020603772,0.021504233,0.021037446,-0.0029110203,0.0265732,-0.040392578,-0.029700771,-0.008595849,-0.07154911,-0.0134417135,0.027161155,-0.015686056,-0.016192475,-0.0065460172,-0.021963524,-0.018782709,0.043239307,0.071414076,-4.714436e-08,0.0007803511,-0.12197941,0.029158903,-0.014424363,-0.057027087,0.04704483,0.0463247,-0.026293768,0.042024165,-0.00013068836,0.05380797,-0.011832446,0.017729815,-0.085392155,-0.008576746,0.050429307,0.0040584607,-0.009448341,0.0028857484,-0.023637641,-0.08646382,-0.021550056,-0.07156777,-0.0043058037,0.008103427,-0.057955235,0.03728788,-0.040720142,-0.0035401904,-0.007789847,0.079484954,0.03346481,-0.056255475,-0.03810537,-0.005666948,-0.036611315,0.035904653,-0.009190379,-0.054780394,0.045531876,0.018701306,-0.029141974,-0.073943436,0.033204854,0.096834056,0.027819531,0.005638364,0.016046975,-0.075650886,-0.065485,0.022194002,-0.018841015,-0.037514348,-0.04097151,-0.1260058,0.13237387,0.034787923,-0.07159286,0.039546423,-0.07660742,0.021718234,-0.018112464,0.15827833,0.068209745 +1.11.2.3,"A heme protein with calcium binding motif (caleosin-type). Enzymes of this type include membrane-bound proteins found in seeds of different plants. They catalyse the direct transfer of one oxygen atom from an organic hydroperoxide, which is reduced into its corresponding alcohol to a substrate which will be oxidized. Reactions catalysed include hydroxylation, epoxidation and sulfoxidation. Preferred substrate and co-substrate are unsaturated fatty acids and fatty acid hydroperoxides, respectively. Plant seed peroxygenase is involved in the synthesis of cutin.",384,0.9999999,-0.085032344,0.025360662,-0.036918234,0.056611724,0.07036649,0.06971043,-0.020493833,0.07220923,0.0762319,-0.0024072856,0.047259983,-0.050644632,-0.14227936,0.019785495,-0.020659165,0.052533865,-0.10294347,0.050771207,-0.04249116,-0.096333414,0.04876664,0.057368267,-0.063433446,0.03230815,0.03900505,-0.053025745,0.002237182,-0.010233185,0.016100042,-0.03943007,0.012948163,0.0007622365,0.09810976,-0.009725368,-0.0012945924,0.08416998,0.015642688,-0.14746006,-0.0110997,-0.02506233,0.10977768,-0.008313149,-0.04860015,0.0029316586,-0.07637803,0.010596874,0.06304483,0.020359091,-0.034852605,-0.013126859,-0.041636426,-0.07477679,-0.09869271,0.008257209,-0.012960595,-0.019030647,0.020794421,0.08963565,0.062125098,0.0014675567,0.031839237,0.012472345,-0.040836878,0.010895082,0.0070467335,-0.082497925,-0.04156913,0.018735427,0.0010815638,-0.09009049,0.013953277,-0.07903757,-0.022843583,0.028765514,-0.060193833,0.066299655,-0.05027654,-0.022849306,0.022373898,-0.04449272,-0.0120621305,0.015669039,0.023609595,0.13652946,0.025041306,0.078605875,-0.027736487,0.027606694,-0.009675739,-0.013330339,0.017434496,0.027625157,0.014645458,0.01024056,-0.03154676,0.07863061,0.103264794,-0.051536266,-0.021457328,0.014919077,0.0075376765,0.106768414,-0.039160874,-0.07443326,0.02003092,0.040687483,-0.07763148,-0.016315565,0.032056257,0.018035378,-0.009447732,0.0056033456,0.026762638,0.0005098854,-0.019008324,0.07504963,0.017988482,-0.053143684,-0.00994964,0.027902596,-0.055550247,-0.04954197,0.011119415,0.040386382,-0.03437188,-0.025845107,-0.081405886,3.7295064e-33,0.04150533,0.017990947,-0.05098082,-0.017318262,0.003628804,-0.04696149,-0.05179331,0.0011468058,0.01577106,0.016377773,-0.09457324,-0.060003996,0.035503983,0.025026528,0.015280964,-0.079861365,-0.02156025,0.033947684,0.033902388,0.08663544,-0.029669262,0.030303966,-0.08432642,0.0038289307,0.019632248,0.046450526,0.006376305,-0.1092735,0.03040575,-0.03663612,0.011855411,-0.07036772,-0.040071003,-0.014964008,0.018285722,-0.02185411,0.002095256,0.006574471,-0.06933163,0.06756154,0.008405269,0.04766616,0.014474668,-0.04370632,0.07140329,-0.11792014,-0.04795319,0.027867831,0.05242825,0.08866844,0.025066128,-0.017050091,0.11030051,-0.043953612,-0.022622574,-0.022180114,-0.017128617,0.04285791,0.07891608,0.028777214,0.062128823,0.012085515,-0.059882093,0.023837812,0.017328173,0.024213599,-0.10411654,-0.047257256,0.016410945,0.05632957,-0.042335615,-0.0049137883,0.02369902,-0.03589917,0.006454703,-0.049058545,-0.049246483,0.08891381,0.043278925,0.019160196,0.054347597,-0.024406232,0.00845318,-0.07176545,-0.055555455,-0.0017148522,-0.04468676,0.030410726,-0.015392224,-0.0055057025,0.080282636,-0.080077976,-0.015822388,-0.038324326,0.017568031,-3.0487974e-33,0.07209904,-0.023228569,0.025642436,-0.09645446,0.03046694,0.03134275,-0.05181309,-0.01639346,0.0119948,-0.029409088,0.05320222,0.0118993,0.030707192,0.004676728,-0.04541182,0.040232033,-0.026735036,0.047606148,-0.02170079,-0.0030233103,-0.09546105,0.06473045,-0.016085535,0.099990495,0.05856023,-0.019845387,-0.029545255,0.014593889,0.029040398,0.028651368,-0.04687972,-0.046182714,-0.06442941,0.032128315,-0.015808929,0.049145892,-0.04853658,0.08698612,0.031688686,0.008170349,0.009801383,-0.05062523,0.017301952,0.0967712,0.039067034,0.049213797,-0.09975339,0.05532312,-0.040376868,0.06471264,0.027488755,0.028990425,-0.06383748,0.01593639,0.008814644,0.00926057,0.031210283,0.030412855,-0.10154441,0.004695822,-0.047959533,-0.058841087,0.07113844,0.041377872,0.012603086,0.03953485,-0.11765843,0.073120154,-0.010642659,-0.0089739645,0.110950574,0.04115802,0.08035263,0.015726883,0.03150637,-0.07732126,0.031660568,-0.0152685335,-0.013500966,0.01700591,-0.041746568,0.067828864,-0.004977795,-0.06895147,0.002815812,-0.0038897372,-0.023751799,0.05026821,0.008264062,-0.02336946,-0.029803867,-0.019564806,-0.014123225,0.08348154,0.096381284,-4.039422e-08,-0.04025256,-0.10946273,0.02516048,-0.02089131,-0.010484505,0.020538045,0.044599947,0.021781089,0.012128706,0.0070777796,-0.02398663,0.08210119,-0.06323323,0.020500325,0.015831638,-0.0018434081,0.057514805,0.07832242,-0.011841916,-0.015709652,0.0015261634,0.009471201,-0.015744027,0.07971054,0.02863327,-0.09410024,-0.022387039,0.0018563251,0.059587084,0.033631355,0.06299663,0.070127174,0.01894174,-0.04204061,-0.030110199,0.0048899297,0.020599559,0.0034761997,-0.069290206,0.009351293,0.013434906,-0.034478806,-0.058584336,-0.07334525,0.00999877,0.029283667,0.051245432,0.020849612,0.026864959,0.041959688,0.057764515,-0.015200198,0.030646177,-0.11090785,-0.1265471,-0.015375884,0.043951582,-0.016701149,0.044770543,-0.07643433,-0.04269082,-0.02474323,0.23719622,-0.021300124 +1.11.2.4,"A cytosolic heme-thiolate protein with sequence homology to P-450 monooxygenases. Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function. Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis). Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalysed by the common P-450s. A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated. Oxidizes the peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction.",384,1.0,-0.07870985,-0.06968123,-0.0446724,-0.03045809,0.0463779,0.022135498,-0.08676686,0.08653524,0.01636432,-0.047155894,-0.02536697,-0.041700907,-0.01608872,0.043572493,-0.040924136,0.03534289,-0.020358998,-0.01268501,0.030725071,-0.07363753,0.03269503,0.024595505,-0.039380778,0.0103314025,-0.02988661,-0.014134781,0.06415296,-0.0025645462,-0.06534072,-0.017748863,-0.020737067,-0.05004245,0.054996293,-0.05088922,0.006225877,0.13780305,-0.10225069,-0.06580848,0.01196216,-0.05908512,0.048189245,-0.06993193,-0.084816344,0.0054794797,0.010082642,-0.06662785,0.039127946,-0.010774987,-0.08794963,-0.07071258,-0.058133226,-0.029735077,-0.05136485,-0.008142478,0.008110167,-0.052616294,0.008878687,0.017842775,-0.061088223,-0.04816282,-0.010097289,-0.02679122,-0.0081029,-0.012107898,-0.01976925,-0.028173715,0.038794734,-0.03305875,-0.026636172,-0.067358464,-0.08865134,-0.020603785,-0.014652453,-0.019884935,-0.03905019,0.06685571,0.019077249,-0.047129817,0.0039803083,-0.046950106,-0.009780588,0.012481147,-0.04738958,0.09504829,0.06383088,-0.034967735,-0.04081918,0.036707647,-0.04449463,0.012442647,-0.001649821,0.048187044,-0.014808081,0.020542746,-0.102399044,0.04034299,0.048166957,0.023735298,0.05855611,-0.04624964,-0.002580418,0.11031615,-0.04255526,-0.05764856,-0.022295328,0.02746683,-0.023698302,0.11437199,0.049032073,0.008919617,-0.005343687,0.04702186,0.040217478,0.014353015,0.012184321,0.06976513,0.013647995,-0.065582104,-0.030869048,0.022802114,-0.05083462,-0.06480765,0.020836787,0.015150954,-0.054845545,-0.0010754043,-0.03917668,6.337223e-33,0.060663342,-0.004649845,-0.025880434,0.06628897,0.025808983,-0.016774168,-0.07307072,0.02010259,0.01710561,-0.010893932,-0.025792817,-0.06462976,0.00051255355,0.046404794,-0.025095515,-0.07196741,-0.052642122,0.06145245,0.04031701,0.026063072,-0.053816404,0.008700542,-0.026396288,-0.022924285,0.047869343,0.079509154,-0.017628701,-0.01851665,-0.03587223,-0.0014354725,-0.013516941,-0.054703195,-0.060751367,-0.06551575,0.05484533,0.025577985,-0.03995007,0.051482063,-0.038862184,0.020921689,-0.018330365,0.020310456,0.026219185,-0.09171997,0.079037435,-0.045943618,-0.054353464,0.12684515,0.0037272898,0.057739187,0.04324828,-0.047124393,0.11947874,-0.0155968275,-0.048152264,0.0008379058,-0.006432692,0.037914343,0.047405895,0.06555404,0.083581425,0.10447909,-0.092110924,0.07322218,0.0016621216,0.031693436,-0.07305686,-0.008147489,0.017027592,0.13984731,0.056298833,0.02431848,0.06113071,0.013315675,-0.015453967,-0.04906669,-0.039051168,0.059107706,0.05588773,0.010861173,0.059914522,0.017856833,-0.047896728,-0.059618253,-0.010358117,0.036644787,0.009366948,0.014119154,-0.0115606515,0.019094385,0.05347991,-0.107609235,0.030784937,-0.035480484,-0.057659283,-6.900044e-33,0.086972825,-0.07186998,0.014922948,-0.14029786,-0.0070498595,0.009328313,0.032102223,0.027250731,0.006635442,-0.033999417,0.050931737,0.0087568825,-0.008289414,0.0002070772,-0.03060685,-0.019632386,-0.035356257,0.0134536745,-0.03691094,-0.007417635,0.040606987,0.060728136,-0.04054019,0.084451504,0.021998601,0.062933885,-0.079103604,0.07719702,0.031971145,0.018857373,-0.03743779,0.025916863,-0.02589889,-0.06591301,0.010000367,0.0416308,-0.08754589,0.07942763,0.053200033,0.039346237,0.033029635,0.056597747,-0.0073132385,0.05825489,0.02364621,0.10051659,-0.17571098,-0.07680413,0.060009986,-0.06309214,0.024400488,0.011416544,-0.018530484,-0.005170598,0.007172986,0.021089563,-0.028432025,-0.0006696838,0.028240051,-0.12921205,-0.09141944,-0.047498085,0.049010303,0.046083234,-0.035382345,0.04663531,-0.03173595,-0.00701658,0.016648348,0.017863743,0.004735591,0.0025412873,-0.007148102,-0.016782098,-0.026427986,-0.034798436,-0.032513414,0.026126474,0.050467603,0.04589124,0.027579052,0.0022106885,-0.043273617,-0.071811296,-0.044598307,-0.087849155,-0.0040968913,0.03570194,0.01308681,-0.022097606,0.020644696,0.05486573,-0.02783013,0.025476327,0.07438506,-5.2293217e-08,0.04078293,-0.09219493,0.07921644,0.05372988,-0.050287306,0.011536645,0.053662326,-0.015605845,0.09865491,-0.029932424,0.026509209,0.06896031,-0.0009580124,-0.005624859,0.023379583,0.03469111,-0.052300375,-0.006923508,-0.0073746485,-0.052170247,-0.076687776,0.01866904,-0.04039597,0.06151988,0.09915291,-0.058678336,-0.010641822,-0.04730908,0.057715088,-0.02521288,0.019631445,0.06290622,-0.008326072,0.022242218,0.04504855,0.018777648,-0.01766375,-0.008915981,-0.07784973,0.04736447,-0.008354064,-0.043381628,-0.09708724,-0.013814101,0.05433808,0.015448527,-0.031415332,0.07241086,-0.015567458,0.015767882,0.033797156,0.011619336,-0.017905787,-0.070480466,-0.12018725,0.04123936,0.043711383,-0.0131322,-0.033427082,-0.06488991,0.11011809,0.05214166,0.21456361,-0.051478658 +1.14.13.119,A heme-thiolate protein (P-450). Kinetic studies suggest that 1beta-hydroxyepiaristolochene is mainly formed first followed by hydroxylation at C-3. However the reverse order via 3alpha-hydroxyepiaristolochene does occur.,384,1.0,-0.04542875,-0.057952933,0.016437223,-0.052596424,-0.029492239,0.025767535,-0.00017079136,0.05439741,0.0252757,0.023844149,-0.0064697787,-0.014768293,-0.060531,0.032712862,-0.021345247,0.025049321,-0.054143194,0.0076370127,0.00016326697,-0.04043829,0.008885852,-0.007255249,0.0077561843,0.046523564,0.022151863,0.018544078,0.0853346,0.047623873,-0.011935659,-0.08884468,-0.038339354,-0.014664979,-0.0026812917,-0.015401583,0.013876859,0.08999308,-0.1301935,-0.09804679,0.03553407,-0.018386884,0.11387406,-0.08482206,-0.057922225,0.006483235,-0.013264815,0.005281376,-0.021158855,0.11820491,0.021780675,0.01550357,2.0617848e-05,-0.096394055,-0.08048956,0.097613126,-0.06486956,-0.021614905,0.029261377,0.099893056,0.023801357,0.01750129,-0.030157331,0.06593923,-0.0010106323,-0.024613691,0.051043082,-0.081726216,0.02433655,-0.060487594,-0.020428108,0.014429627,0.001127688,-0.019816011,0.03362701,0.05736536,-0.047385283,0.037641495,-0.029556386,-0.024080893,-0.014455018,-0.04701513,0.0034161243,0.045300797,0.019813418,0.13680336,0.019588668,-0.009242222,-0.07550178,0.029375264,-0.05020666,-0.060366396,0.0023336608,0.039745633,-0.029840574,0.0059445556,-0.06533494,0.06431929,0.0907299,0.009475599,0.0586456,-0.03916065,0.03218982,0.030200582,-0.015486143,-0.041345157,-0.0254291,0.019637078,-0.048637476,0.05732629,0.04818712,-0.0033534032,-0.01160346,-0.025382807,0.07317695,-0.064106405,-0.07147317,0.11121188,-0.04374527,-0.0039035464,0.03224713,-0.091286495,-0.061740853,-0.048298117,0.0375609,0.0018768524,-0.12074262,0.018907318,-0.02357586,5.4973345e-33,0.06745259,-0.0075214817,0.006475255,0.06298853,-0.036579125,0.0060337973,-0.055035517,0.03026428,-0.04792935,-0.048911396,-0.046278212,-0.10432164,0.035305534,0.008347096,-0.09748921,-0.080182165,-0.037873827,0.04377604,-0.032588236,0.0054072095,-0.054274376,0.04831852,-0.014619574,-0.030309897,-0.034429353,0.029775126,0.023626946,-0.031281628,0.07323131,-0.006717146,-0.00758139,-0.033646304,-0.06897583,-0.028272646,-0.0037044038,0.017859505,0.031795733,-0.017732263,-0.049199194,0.045062274,0.033013456,0.00509361,0.005255062,-0.13878334,0.09246611,-0.015986647,-0.07818119,0.012311088,0.042377345,0.002637032,0.0577922,-0.0026001257,0.10747135,0.057134207,-0.08513258,-0.044381805,0.0061122403,0.016421674,0.057522926,0.04316834,0.11283271,0.076367915,0.0023355,0.061614566,-0.052554548,0.056091994,-0.05471955,-0.0018676642,-0.018063786,0.079056606,-0.02497396,0.028950995,0.059337784,-0.026420426,0.08541258,-0.015870767,-0.033975203,0.07379879,0.0100059835,-0.006428568,-0.013054098,-0.022239968,0.0019084391,0.02255154,-0.05705155,0.012615457,0.055733208,-0.0015004922,-0.0061258883,0.052658048,0.07159784,-0.096560225,0.013669927,0.011220866,0.0013008838,-5.5713815e-33,0.058720272,-0.10248875,0.021225607,-0.084692195,-0.039117064,0.0075174198,-0.009330909,0.0067946785,-0.03791025,0.023703754,0.19339877,0.0033627192,-0.0704521,-0.059821866,0.0041758907,-0.022712689,-0.035995554,0.007747742,-0.031220965,0.036809284,0.02068984,-0.037827134,-0.009208568,0.07902226,0.047093775,0.013082628,0.019925127,0.014935655,0.079438545,0.048618708,-0.04930631,0.03738879,-0.06631286,0.018407673,-0.062237363,0.012991353,-0.050703984,0.023320531,0.021282598,0.020023456,-0.040589932,0.032513473,0.02613851,0.09772821,0.06978328,0.09316856,-0.05765199,-0.027313147,0.03977706,-0.016492736,0.019751199,-0.026956704,-0.011234765,0.018053254,-0.0030550007,0.035930354,-0.049335573,0.034343403,-0.025606995,-0.098479405,-0.053898565,-0.0012658518,0.0564856,-0.026286874,0.03004488,0.08944062,-0.09480571,0.046656158,0.09080647,-0.018185727,0.01306502,0.056069985,0.014989227,0.023786651,0.036420517,-0.041129414,0.04609376,-0.0065198625,0.033926114,-0.026985802,-0.0042383773,0.060388528,-0.044439778,-0.06456052,0.015877845,-0.04783374,-0.034223635,0.07233193,-0.023751823,0.009651536,-0.009962626,0.053389665,-0.06581126,0.042068098,0.08945619,-4.1458964e-08,-0.007482421,-0.12056898,0.020138815,0.002921433,-0.013729572,0.015168274,0.03814422,0.03896305,0.09417298,-0.06337964,-0.057325985,0.044773236,-0.00079737295,-0.0535755,-0.015845807,-0.023837255,-0.031558543,0.022513134,-0.020856038,-0.036815874,-0.064888045,-0.012135656,0.012174308,0.03472917,0.004543181,-0.028494943,-0.03540933,-0.07528282,0.02881784,-0.032954384,0.0058241044,0.08569906,-0.03272506,0.013704293,0.061705172,0.05926599,-0.07794011,0.031474702,-0.03433357,-0.040593054,0.007849171,-0.06514231,-0.038907498,-0.04598911,0.062920466,-0.03848682,-0.016479282,0.046685763,-0.019398712,-0.04446468,-0.009757935,-0.008231291,-0.0016515062,-0.08266545,-0.12703437,0.014489537,-0.024332449,-0.052127916,-0.05202537,-0.10247151,0.03564418,-0.013531802,0.21456333,-0.0069764256 +1.14.13.120,"A heme-thiolate protein (P-450). The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien-12-oate to give 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which probably spontaneously cyclises to form the lactone ring.",384,1.0,-0.05530123,-0.00059323816,-0.05704574,-0.05000902,0.039282326,0.071347125,-0.019661574,0.110163115,0.041968137,-0.034385975,0.020029608,-0.018474549,-0.08900807,-0.03144811,-0.033265293,0.033815283,-0.111537404,0.055506017,-0.041323308,-0.021214288,0.040551864,0.038854063,0.03341466,0.07526464,0.03055692,-0.042622983,0.08725953,0.053283494,-0.0008400142,-0.054452337,-0.0047487025,-0.05272758,-0.029979045,0.06591748,0.003098295,0.0669886,0.008913484,-0.04562341,0.050690316,-0.01361921,0.0679067,-0.041265085,0.01463419,-0.0010305255,0.0025498874,0.014340643,-0.022813933,0.06601149,-0.014141417,0.0037068839,-0.013168682,-0.099753544,-0.04451477,0.010751006,-0.023004798,0.0485044,-0.04747264,-0.07003386,0.09687789,0.034707855,0.023197513,0.03087273,-0.011479623,0.04643262,-0.02941656,-0.059200168,0.05923646,-0.005867865,0.004041679,-0.021745939,0.03234982,-0.07660811,-0.008520867,0.016428951,-0.05462372,0.10664845,-0.04752401,-0.033543408,-0.0067360955,0.012419272,0.00011304171,0.02976309,0.021164741,0.1662612,0.04579227,-0.04854963,0.03129139,0.0328703,-0.01910126,-0.0074063027,-0.01727455,0.033536784,-0.07129937,-0.032267436,-0.13654338,0.047055706,0.10635068,-0.020502822,0.025982684,0.0023036252,0.010897636,-0.0050029205,0.026923588,-0.055400066,-0.056802765,0.03535399,0.014685612,0.04133811,0.09440615,-0.021354284,-0.0961155,-0.02632709,-0.0048745973,-0.014361782,-0.054228205,0.1386634,-0.0035824478,-0.0049058613,0.02421516,-0.019024061,-0.02779991,0.026273843,0.0015263425,0.05441207,-0.06569492,0.01849111,-0.08940944,1.2524369e-34,0.089084126,0.009364474,0.09555135,0.034272112,-0.0005836297,-0.03307585,-0.09857371,0.00039918057,-0.059537254,-0.028308395,-0.009771194,-0.07980743,0.021849431,-0.026677247,-0.008141159,-0.014299297,-0.033858154,-0.013906201,-0.014659213,-0.054917302,-0.115468904,0.051628716,0.014310658,0.05086673,0.035363626,0.0702117,0.02811884,0.004825158,0.0674368,0.025203222,-0.025963414,-0.06004364,-0.04826126,0.023687925,0.016423747,0.045936994,-0.03305027,-0.02165358,-0.0035789036,0.01886886,0.050274204,-0.06272818,-0.022385407,-0.079184175,0.04280025,-0.06998797,-0.060564686,0.056058932,-0.0012653312,0.011036809,0.055188846,-0.05001598,0.011132748,0.11652811,-0.09688731,0.0076224306,-0.051065143,0.03947617,0.0593896,0.012073852,0.1348847,0.00055879226,-0.0011423544,0.057956442,0.02303272,0.04795821,-0.067073956,-0.05418174,-0.030563226,0.05361282,-0.047844864,-0.008182276,0.014146867,0.03455602,0.039138265,0.023514727,-0.032291528,-0.0148407575,0.0028069748,0.06388936,0.026313841,-0.04868238,-0.0343653,-0.0027758677,-0.04254413,-0.015218971,-0.016784934,-0.017946936,-0.010298525,0.037972394,0.09686177,-0.084480174,-0.01295537,-0.003117108,-0.046938334,-1.0554896e-33,0.046860654,-0.085262366,0.0346611,-0.008714876,-0.0066512167,0.009538174,0.03378275,-0.047359727,-0.05726766,-0.044366647,0.10847469,-0.08405372,0.009441554,-0.07043421,0.0012799625,-0.0008131955,0.012067916,0.08387955,0.08636052,0.055832744,0.036916878,0.016187156,-0.039920606,-0.012585862,0.021978088,0.064743415,-0.027330635,0.011903204,0.06359037,0.05233969,-0.06269114,0.050230928,-0.0067593316,-0.056676164,-0.059344735,0.064368024,-0.019749066,-0.009520577,0.060942985,0.012277544,-0.07867514,-0.017673107,0.030480374,0.0535351,0.0823162,0.1003657,0.05641752,0.026606943,0.00052401173,0.0074757244,0.08392089,-0.02090868,-0.001880701,0.02053521,-0.0050913575,0.026463222,0.00096437556,-0.009090469,0.012428815,-0.04754699,-0.021442888,0.022680862,-0.026876053,-0.027738888,0.015809251,0.096278906,-0.049893454,0.02559142,-0.010223535,-0.00819684,0.08421891,0.08103605,-0.01010386,0.026180064,-0.040347386,-0.01416622,-0.029372992,-0.07792777,-0.05456684,-0.058732793,-0.03441218,0.029812803,-0.012277235,0.004411715,0.016158486,-0.045737673,0.036950555,0.088287026,0.01775253,0.046523195,-0.038510673,0.024932742,-0.087985605,0.11974267,0.0945964,-4.6422958e-08,0.02378505,-0.114831336,-0.02781433,-0.061980516,0.017663127,0.005952638,0.06233117,0.0147663625,0.042876013,-0.09260882,-0.026056409,0.106891915,-0.009134097,-0.056981344,-0.014339999,-0.03969093,-0.024338435,0.042091683,-0.04238666,-0.051226903,-0.011267033,-0.009997492,0.009773452,0.008093691,-0.04982035,-0.092010126,0.004746341,0.08000041,0.006799166,-0.08789109,0.026523793,0.081098594,-0.015720733,-0.046578016,-0.010380153,0.08483903,-0.08889677,-0.05657264,0.0044510853,-0.061068796,-0.008131129,-0.029959513,-0.10136969,-0.039214488,0.0048455475,-0.020100717,0.0038176037,0.0286946,-0.024859602,-0.0068437676,0.0043640407,0.02319564,0.001224282,-0.03697893,-0.099205226,0.0042914776,0.03644345,-0.04828231,-0.0405672,-0.106178895,-0.039262954,-0.042616695,0.20746645,-0.042500187 +1.14.13.121,"A heme-thiolate protein (P-450). The enzyme from the plant Hyoscymus muticus also hydroxylates valencene at C-2 to give the alpha-hydroxy compound, nootkatol, and this is converted into nootkatone. 5-Epiaristolochene and epieremophilene are hydroxylated at C-2 to give a 2beta-hydroxy derivative which is not further oxidized.",384,1.0,-0.02910891,0.04136664,-0.034223504,-0.019410409,0.05979494,0.0730996,-0.015898492,0.0782881,0.024762288,0.016878348,0.042046785,-0.032450054,-0.11767857,0.02608511,-0.065886594,0.047300313,-0.06389911,0.039437667,0.040412158,-0.043866582,0.025605485,0.0680703,0.009296412,0.06676457,0.014517356,-0.0030526945,0.02076985,0.04205178,-0.007166898,-0.11910371,-0.059469167,0.0069479253,0.07856798,-0.011464479,0.0063854107,0.11838186,-0.029142113,-0.12562692,-0.020657782,-0.01026304,0.11454289,-0.035345696,-0.08172417,0.056134358,-0.06594517,0.0084667085,-0.011144574,0.026854543,0.011015773,0.02334805,-0.004533028,-0.10126807,-0.062592536,0.010865068,-0.069194674,0.02872343,0.010853297,0.08829446,0.034902748,-0.026645951,0.016135368,0.04270441,-0.018784342,0.016813241,0.022698678,-0.059995253,-0.0033750937,-0.02250728,0.00029424074,-0.032879233,0.0270757,-0.044141613,0.011712126,0.012424289,-0.071940355,0.023108719,-0.07369157,-0.009287959,0.04016986,-0.0014091209,0.008048425,0.046396885,-0.016305637,0.09050533,0.03077418,0.020933028,-0.0713618,0.036370683,0.00015589625,-0.08722329,0.014777533,-0.011721505,-0.046124212,-0.010420007,-0.08420731,0.055427562,0.04792505,-0.01803499,0.014532684,-0.0064964737,0.024358613,0.041000385,-0.025062278,-0.08947386,-0.05335072,0.028394442,-0.05996332,-0.009079092,0.09258765,0.0037303343,-0.06756954,-0.0014887897,0.054766696,-0.04124356,-0.06767179,0.07311017,-0.020021282,-0.008918146,0.0048346734,-0.035217106,-0.03223381,-0.0471276,0.009418933,0.025538951,-0.11368935,0.023508945,-0.06550148,4.627077e-33,0.08283696,-0.0037870992,-0.0139606735,0.049403165,0.0031226298,-0.029766837,-0.043464582,0.008482024,-0.020913433,-0.069113985,-0.09839525,-0.051747307,0.035193916,-0.0020720242,-0.012675408,-0.09456669,-0.04561682,0.06277151,0.097505294,0.05842531,-0.057885624,0.07876581,-0.055947166,0.030841967,0.022800453,0.010405732,0.052688237,-0.020697482,0.06126068,0.0014819026,-0.019328086,-0.05256988,-0.01384315,-0.05185059,0.037691366,-0.0032161535,-0.01558725,0.00253354,-0.025151292,-0.0034623432,0.009620313,0.011636271,0.008681853,-0.056278847,0.049967162,-0.035186324,-0.05798309,0.017513234,0.0046376814,0.013442533,0.05842558,-0.033503763,0.047513418,0.08327845,-0.067122705,-0.0088740345,0.0017291867,0.038810097,0.037529204,0.035664648,0.11960693,0.09003578,0.011585335,-0.02466528,-0.019438157,0.029634846,-0.10873639,-0.025037266,0.009772025,0.07525646,-0.029570138,-0.0150606,0.03279222,0.0068757385,0.013359682,-0.03166959,-0.052915394,0.0581503,0.059075903,-0.011460506,0.021035094,-0.050656166,-0.006203182,-0.006275299,-0.0067581413,-0.023707697,0.036381327,0.029530633,-0.009272228,0.011208787,0.09297518,-0.08440967,0.010927641,-0.006789875,0.0017569608,-4.2512076e-33,0.07598976,-0.11078409,0.04033969,-0.040340964,-0.051921062,0.05397307,0.01998006,-0.04967475,-0.018460317,0.032771885,0.13912411,-0.00131302,-0.015750544,-0.03781484,0.061866757,0.012929442,-0.02655925,0.049463592,-0.048621945,0.036986932,-0.028568527,0.025985776,-0.07561352,0.046969194,0.014968414,0.056089535,-0.032665346,0.010187676,0.05972582,0.04217787,-0.066301435,-0.008891922,-0.0794933,-0.0086766705,-0.031077404,0.00027720837,0.002777805,0.033256996,-0.01138824,-0.013581776,-0.006262354,0.058341984,0.061941855,0.0927881,0.041567206,0.058379773,-0.085963026,-0.03844819,-0.013688776,0.0044507906,0.035748273,0.014226557,-0.036985833,0.03906255,-0.045965753,-0.035673402,-0.058544703,0.0010919828,-0.043003865,-0.091874495,-0.021306807,-0.081533074,-0.030795565,0.056838013,0.0186309,0.071790494,-0.08778495,0.037067614,0.027342815,-0.009665865,-0.0036317213,0.039992478,0.08889301,0.057420783,0.020520087,-0.030773034,0.013389026,-0.04990273,0.011781875,-0.04920913,-0.04446125,0.016088586,-0.051906765,-0.062728144,0.04470932,-0.08114162,0.016732367,0.07193826,0.035777077,0.03621402,-0.0041326573,0.047899373,-0.07240634,0.08239299,0.1422001,-4.7349936e-08,-0.037673596,-0.1392247,0.0141611975,-0.017724294,-0.026925307,-0.047331933,0.023639945,0.0034202742,0.10533709,-0.02740761,-0.026753452,0.0949066,-0.031574495,-0.015989996,0.032558087,0.01779824,0.04787049,0.08789262,0.01370974,-0.0029112927,-0.08819646,0.024313524,-0.01704706,0.041610137,0.018064355,-0.07220341,0.039005354,-0.027980745,0.044575345,-0.04490055,0.04951457,0.07920504,-0.046302684,0.0047556967,0.0039295848,0.07869371,0.0011668107,0.013435212,-0.04138987,0.028484663,-0.036802467,-0.058189087,-0.08739518,-0.014348995,0.03704884,-0.04372786,0.047920782,0.0542011,-0.008615582,-0.014788585,0.033419274,0.014344849,-0.008122161,-0.12709706,-0.12261821,-0.039645337,0.010461814,-0.025793064,-0.046258707,-0.09235125,0.01233261,-0.021100884,0.24372393,-0.04023708 +1.14.21.8,"A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that does not incorporate oxygen into the product. Catalyses a step in the biosynthesis of (-)-maackiain, the main pterocarpan phytoalexin in chickpea (Cicer arietinum).",384,1.0,-0.048839,0.014743973,-0.09817356,0.017967083,0.051308174,0.052906748,-0.039358165,0.022281768,0.028805617,0.00440235,0.008958103,-0.018595176,-0.06437494,0.014470264,-0.0886328,0.032550093,-0.07458971,0.028127512,0.0044956394,-0.060835443,0.0140480185,0.06602242,0.02016622,0.056904946,-0.05126647,-0.013132581,0.0340724,0.048436277,-0.04691833,-0.025173597,-0.07445324,-0.04566653,0.061779123,-0.04847644,-0.03393718,0.13049299,-0.07835246,-0.033372875,0.06666327,-0.040747922,0.07654439,-0.1141047,-0.056136988,0.004319167,-0.021187844,-0.059637427,0.014829848,-0.0022611925,0.014875166,-0.072436035,-0.06646521,-0.030641697,-0.116699964,0.029451948,-0.013894396,-0.027518922,0.025277592,0.025715424,0.031025767,-0.05654936,0.016117943,0.045734383,-0.043444704,0.01661768,0.010492441,-0.093781136,0.004629115,-0.026634082,-0.052779473,-0.031324867,-0.011028246,-0.04808241,-0.044704784,0.02522535,-0.014928412,0.06293021,-0.058781195,-0.012736984,0.006076857,0.047527593,0.042907476,0.036910683,-0.038960814,0.0770229,0.06925568,0.040964697,-0.058036834,0.021258373,0.029155476,-0.053786192,0.06257286,0.07045965,-0.017936846,0.033698186,-0.068511754,0.028996259,0.019569615,0.019719647,0.012644886,0.010549641,0.026340105,0.047047686,-0.11068133,-0.07014349,-0.019684767,0.018040402,-0.0020433418,0.017046956,0.101521686,-0.009888861,-0.06683887,-0.08400082,-0.014517112,-0.021576809,-0.0029271601,0.12565285,-0.030877126,0.012042217,0.04202527,-0.039136436,0.009045109,-0.029104589,0.039734986,0.047912456,-0.07887139,0.010331074,-0.11527746,3.828745e-33,0.06019402,0.020649144,0.025228575,0.03919882,0.061230045,-0.05586035,-0.09330987,-0.05052559,0.015341184,-0.017189829,-0.113943845,-0.064275995,-0.022343079,-0.028093243,0.063321665,-0.061446186,-0.05742863,0.013005521,0.058874786,0.049002357,-0.038781445,0.012996962,-0.043290902,0.07641337,0.052121826,0.09557228,0.026191333,-0.043234475,-0.005596259,0.013037697,-0.01867041,-0.037147585,-0.044890326,-0.0861276,-0.052555215,-0.034680158,-0.04133857,-0.046918403,-0.058341112,0.042440176,-0.09618679,-0.02855444,0.015963227,-0.018336913,0.027607312,-0.018662129,-0.061118692,0.1074338,0.026566133,0.06338963,0.045461323,-0.03255403,0.11863565,0.02593868,-0.07693766,0.0030511413,-0.01590369,0.016173558,0.087987155,0.075888254,0.07718762,0.017446611,0.0002422781,0.020436153,-0.02428926,0.044333734,-0.082512714,-0.0101920385,0.057199728,0.10590973,-0.02913193,0.042991165,0.0059893853,-0.028233843,0.036494136,-0.021726288,-0.0024077073,0.06124808,0.018816322,-0.030885693,0.02997047,0.006794954,0.017988725,0.0025290854,-0.0022995323,0.04049026,-0.020544423,0.0031706844,-0.022604896,0.014080285,0.0708053,0.005159919,0.007898069,-0.04582166,-0.011358176,-2.224336e-33,0.112901784,-0.06702618,-0.024188643,-0.08164787,-0.059078027,-0.027361041,-0.06778533,-0.05760642,-0.016358899,-0.033268362,0.006851458,-0.06730453,0.04558939,-0.0011752606,0.008131128,0.049591538,-0.0029431994,0.035354096,0.011278836,-0.0021357285,-0.037536547,0.039874874,-0.036510076,0.014176299,0.045529906,0.022650372,-0.028333478,0.038705286,0.08073878,-0.0029127211,-0.046021592,-0.0033752322,-0.050097544,0.034669418,-0.09258659,0.1112119,0.032762762,0.062443465,0.048539307,0.10475673,0.048074853,0.028960915,0.030886974,0.05653266,-0.02352425,0.06757268,-0.058018323,0.0006936742,-0.019884551,-0.077328555,0.08930527,0.059604503,-0.0021205056,0.00301591,0.054252606,0.04651949,0.03757028,0.0010832311,-0.005292392,-0.06428119,-0.0154078575,-0.009484813,0.0053112907,0.0307938,0.035202593,0.079696566,-0.02953872,0.04421071,0.05048697,0.000113236616,0.07754052,-0.0009433392,-0.0012961886,0.028020963,-0.008491834,0.0056963814,0.005457579,-0.003964872,0.071501374,0.051675048,-0.0045262026,-0.00030264608,0.011543303,-0.10997166,-0.057318646,-0.05785188,0.0007864408,0.1296069,0.01766524,0.025282139,-0.0124470405,0.050630495,0.017718311,0.06177295,0.07482792,-3.479919e-08,0.020019172,-0.101737805,0.011840999,-0.025908595,0.029092858,0.02095142,0.049175017,-0.0050155455,0.08133286,-0.035243757,-0.02863211,-0.008778949,0.030391768,-0.009715789,0.0061546545,0.06685659,0.024835663,0.05715602,-0.0004244863,-0.0055319923,-0.10685482,0.068157256,-0.102769986,0.0076170485,-0.0140117835,-0.08518899,0.0032020842,0.02999939,0.007042031,0.0020089897,-0.028658222,0.084092,-0.028369315,-0.074313276,-0.03888189,0.03858119,-0.047756623,-0.038134255,-0.007003703,-0.037732612,-0.05547272,-0.048088513,-0.06006512,-0.03864608,0.0039911615,-0.0007813681,0.021690158,0.0003090373,-0.019595016,-0.022547312,0.052408982,0.056427605,0.060222235,-0.06017178,-0.095001414,0.019112019,0.07735099,-0.0062385607,-0.02141241,-0.0977936,0.017614026,0.0300856,0.25683665,-0.015860107 +2.1.1.200,In Escherichia coli YfhQ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine32 in tRNA. No methylation of cytosine34 in tRNALeu(CAA). In vitro the enzyme 2-O-methylates cytidine32 of tRNASer1 and uridine32 of tRNAGln2.,384,1.0,0.0038196684,-0.03808338,-0.15579669,-0.08576269,-0.038593065,-0.022944355,-0.045655873,0.04610205,0.024680803,-0.012043909,0.07637706,-0.046020117,-0.056893084,0.04980149,-0.015722277,0.04575162,-0.13271059,0.016197847,0.017700646,-0.07280165,0.0448951,0.06267054,0.0033180674,-0.0009024004,-0.070144735,-0.032856315,0.0030027549,-0.03572587,0.025129996,-0.025859622,-0.08142755,0.035961546,-0.009672837,-0.04916614,0.08764637,0.026881855,-0.03565577,-0.005831488,0.08030816,0.026253557,0.0288366,0.016117403,-0.01679181,0.0070411684,-0.020265877,-0.061394837,0.053460706,0.03446199,-0.010967621,0.035612356,-0.01821272,-0.010629322,-0.0070317117,0.055882063,0.04465348,0.03201112,-0.038044106,-0.036174905,-0.009956173,0.034264755,0.03872021,0.03893397,0.01291424,-0.055667322,0.1002129,-0.0622594,0.055442985,-0.045361158,0.0131142195,-0.05198058,-0.037907664,-0.042682867,-0.044569436,0.08130232,-0.03646874,0.03295275,0.015654728,0.0358338,-0.02694536,0.022221195,0.01926365,-0.0760572,0.068084225,0.020624178,0.04539702,-0.008569104,-0.080713585,0.08429901,0.03435984,0.102967605,0.028128034,0.04007366,0.041811045,-0.05944828,0.009498796,0.02950138,0.043788753,0.028076515,0.083931245,-0.04770787,-0.011758952,-0.014789553,-0.04715107,0.040898576,-0.033912096,0.013581162,0.068320334,0.036116533,-0.06422223,-0.020077014,0.0074546332,0.037828118,0.060281474,-0.024679318,-0.028934237,0.07002076,0.03345004,0.025343137,0.01153531,-0.08886907,-0.04466502,0.014473309,0.018526949,0.035437714,-0.015774863,-0.013000267,-0.089830995,4.928074e-33,0.058407873,0.077324085,0.037615474,-0.012668519,0.049123,0.0113457525,0.028820539,0.01768869,-0.007373393,-0.0965052,-0.09231748,-0.10387618,0.043006543,-0.051861376,-0.035114292,-0.025277367,-0.038790952,-0.044401605,0.033272594,-0.057164084,0.04876222,0.037752822,0.030748596,-0.03723376,-0.0070358254,0.003826419,0.026669737,-0.03479489,0.041266304,0.0009862017,-0.03893954,-0.0864787,-0.058228187,-0.027059408,0.14374706,-0.018601522,-0.023564445,0.040451054,-0.053835224,0.076845646,-0.018904611,-0.001856984,0.04671037,-0.041194737,-0.05078268,-0.026695713,-0.041755106,-0.005482972,-0.017082406,0.054800082,-0.000345455,-0.0137965735,-0.049111955,-0.04654967,-0.030431103,-0.031711068,0.044019673,-0.05364836,-0.027050747,0.048358474,-0.025963198,-0.006180156,-0.026126884,0.050277244,-0.06014142,-0.036912415,-0.0602802,-0.09940837,-0.029456727,0.0983824,-0.016853677,-0.05192848,0.12203894,-0.031611606,0.09190099,-0.05234119,-0.12537272,-0.003939113,0.02739513,-0.031663034,0.0051825405,0.02484166,-0.004617694,-0.012903223,-0.011600741,-0.029147398,0.055255678,-0.005423529,0.014083448,0.08243115,-0.047190536,-0.06754587,-0.012404797,-0.0052704075,0.055333734,-5.858175e-33,0.01702328,-0.041618314,0.06487364,-0.10013084,-0.08656214,0.002252587,-0.020021463,-0.02176392,0.0048820684,-0.06637355,0.09196142,0.048335113,-0.024999917,0.015531056,0.022451794,-0.05943922,0.01348542,0.04762688,-0.058171373,-0.045938183,0.060961165,-0.05366279,-0.02421965,0.08004259,0.04313932,-0.017054198,0.04956826,0.10673271,0.025695741,0.021124173,-0.065416604,-0.003821358,-0.009816637,-0.004045202,0.0073703397,0.039700106,0.020828871,-0.011112839,0.0011109731,0.021014737,-0.04383074,-0.028956175,-0.06845984,0.12482219,-0.038928203,0.094011545,-0.033213492,-0.0246827,-0.02416733,-0.029074393,0.11147377,-0.003607737,0.035860028,0.006814512,0.04958088,0.036535107,-0.02059628,0.039741606,-0.0211438,-0.012766726,0.021823553,-0.0189133,-0.068746395,-0.05009595,0.06363953,-0.006404729,-0.027902856,0.07244644,0.030384172,0.015499388,0.0067475582,0.00064698426,-0.029779753,0.037612014,-0.048068035,-0.13277592,-0.11808635,-0.054539796,0.03703014,0.0005911255,-0.0030390567,0.003107632,0.020771647,-0.032839764,0.053682175,-0.046304196,0.062888905,0.13349117,-0.050765738,0.033431567,0.025532853,0.0030999144,-0.033879384,0.07371456,0.0094854785,-3.780556e-08,-0.030910047,-0.100169115,-0.08129326,-0.0072613107,-0.053071335,0.055608403,-0.06717671,0.07488154,0.065427445,0.0050073387,0.02058958,0.056913987,-0.005012514,0.091646954,0.008183402,0.065443754,-0.085215755,-0.024973257,0.024355857,-0.03214049,-0.020494545,0.05639663,-0.13767046,0.014765714,-0.0034014056,0.010291601,-0.02922341,0.09851033,-0.002151585,-0.058813997,0.084260605,-0.03483883,0.03399504,0.022643927,-0.078366406,-0.013229127,0.055352483,-0.06936852,-0.0047421386,-0.012684986,0.033202883,0.08317727,-0.11696623,0.04104261,0.0046752742,-0.023289887,-0.06301006,0.08207689,-0.02582371,-0.026149966,0.036463037,-0.01828313,0.04893724,-0.0043677054,-0.0415806,-0.036770377,-0.02211625,-0.048331793,-0.05324926,0.023125187,0.07232678,0.015899915,0.17867988,-0.045394477 +2.1.1.201,"This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant [3]. The bifunctional enzyme from Escherichia coli also catalyses the methylation of demethylmenaquinol-8 (this activity is classified as EC 2.1.1.163) [1]. ",384,1.0,-0.048845056,0.0044961977,-0.10113726,-0.025684582,-0.02128737,0.04730049,-0.046870936,0.037395734,0.031309422,-0.058569383,0.006880875,-0.051093586,-0.047367353,0.0146846725,-0.031914912,0.03713802,-0.066399805,-0.014901904,-0.05943673,-0.051357634,0.09242332,0.06063475,-0.010353966,-0.026035905,0.03012349,-0.05323836,0.06979052,0.015983492,-0.0057312753,-0.05144345,0.0628409,0.010286428,0.06590736,-0.085162684,-0.024072714,0.097520195,0.0010795479,-0.068803295,0.0047333334,0.04376389,0.027841661,-0.034809537,-0.055195786,0.13911627,0.0062877415,0.025219578,-0.039806787,0.060809232,0.07278932,0.011875178,-0.035000417,0.02096033,-0.0025483088,0.08195141,0.041098423,0.027838316,-0.060539875,0.011830146,-0.008087217,-0.04011307,-0.029122718,0.020213138,0.062459406,-0.028314115,0.0056167054,0.034358643,0.015337997,-0.096447915,0.012136849,0.020560335,-0.027003892,-0.06982521,-0.06669696,0.040215995,-0.086114176,0.096406676,-0.0068119806,-0.04598005,0.03575059,-0.03787455,0.008468534,0.0078333225,0.08480904,0.0070873066,0.0631127,0.013497861,0.034812544,-0.022044335,0.040451758,0.04814501,0.035235543,-0.04327474,-0.029052502,0.0016381589,-0.0082510365,0.008343736,0.07462193,0.09414457,0.019467209,-0.037571304,0.050247874,0.04013194,-0.03632405,-0.031220423,-0.026635887,0.025599329,0.11161727,0.082318716,0.011155258,-0.0059492174,-0.02924985,-0.029685631,-0.013054456,-0.02386087,0.021902382,0.004982011,0.102575295,-0.014710678,-0.049885828,-0.048917994,-0.010729497,0.0404109,0.059237454,-0.010963006,-0.06989656,-0.014324698,-0.14373569,3.340535e-33,0.08506715,0.022846723,-0.008498108,0.019279322,-0.028541517,-0.004958395,-0.09063309,0.040613584,-0.05845136,-0.044752106,-0.022307763,0.0032314158,0.016207404,0.034834772,-0.016610438,0.0140966205,-0.002911268,-0.087747216,0.08440891,-0.054016527,-0.07016639,0.020545334,-0.047355596,-0.057466768,-0.018562494,0.023067208,-0.04284679,0.05218911,-0.053694203,0.007821469,-0.06901564,-0.061013993,-0.111914776,-0.017592756,0.009046582,0.033602785,-0.06829197,0.034496754,-0.041987304,0.044559434,0.00037020887,0.021467196,-0.027950883,-0.036695756,0.09606615,-0.024051692,-0.0512425,0.057799637,-0.018461531,-0.012772244,0.010377549,0.067100786,0.0869713,-0.050329868,-0.09196363,0.0020820412,0.059951473,0.04752696,-0.03322052,0.043491926,-0.061308283,0.049003195,0.0067461524,0.05742955,-0.0377681,-0.018017504,-0.017142344,-0.033653047,-0.03778581,0.078083046,-0.006211859,-0.062418044,0.04249863,0.011057941,0.03059694,-0.008085014,-0.031225545,-0.002170903,0.049956158,-0.0009150242,-0.05711961,-0.049012497,-0.03288407,-0.05857139,-0.041887373,0.014770979,0.015197783,-0.015604289,-0.08601888,0.021545412,0.091452636,-0.037573174,2.2084869e-06,0.032385513,0.04809178,-5.4322915e-33,0.06254439,-0.06242419,0.050366122,-0.07315978,-0.0403382,0.11169366,0.09071934,-0.018475067,-0.0386441,-0.039228175,0.11176037,-0.033865467,0.03177407,-0.0048244796,0.011240757,0.015864799,-0.029161658,0.0887022,0.027394563,-0.025998648,0.097350195,0.09468861,-0.055214826,0.023410972,0.038683284,0.025039133,-0.01964139,0.0360493,0.06202505,0.0133270435,0.00086616393,-0.030449552,-0.041972492,-0.0117356805,-0.04434788,0.01968767,-0.048935223,0.055250958,0.024146955,-0.004361132,0.020017961,0.0030311064,-0.058274355,0.036015812,0.04010692,0.11772909,-0.037186097,-0.013949506,-0.044438817,-0.012280211,0.056579527,0.015150167,-0.10652243,0.041336495,0.004876367,0.079951525,0.014765609,-0.028429423,0.039908808,-0.0049196705,-0.0175887,-0.028498888,0.025068343,0.00055248226,-0.04622614,0.07648783,0.032047827,0.021729672,0.021136774,-0.046775635,0.062135134,-0.024156127,0.0031155774,0.010550475,-0.06695309,-0.024029052,-0.054665986,-0.06226847,-0.000637493,-0.020343313,-0.023667032,-0.054033395,0.028613191,-0.013353348,-0.066431105,-0.095332526,0.10010575,0.06592237,-0.00091804133,0.07375627,-0.04645546,0.038839534,-0.1261724,0.015924368,0.043619443,-4.559766e-08,0.04361312,-0.0843898,0.041729745,-0.08034041,0.034702618,0.015567296,-0.06155445,0.0497143,0.04837415,0.07449506,-0.026570346,0.015482157,0.010481315,0.07795079,0.07300872,-0.009129357,0.019031348,0.0024172692,0.024319503,-0.07897785,-0.057737093,0.05736669,-0.05282133,-0.006357297,0.0213432,-0.10314315,0.02246221,0.08624068,-0.0019492358,-0.08176511,-0.031549826,0.07586243,-0.038461007,-0.03033183,-0.072349854,0.03520389,-0.048460234,-0.093944915,-0.0018547727,-0.023473017,-0.057637677,-0.080282144,-0.031644236,0.057492923,0.039834283,-0.020949729,0.061672177,0.035207596,-0.01004764,-0.050797593,0.041990984,-0.047585614,0.039921932,-0.06875351,-0.09251894,0.069502555,-0.08861164,-0.07638334,-0.0005343572,-0.119006425,0.007630373,-0.009659352,0.13430914,-0.12702297 +2.1.1.202,"The enzyme from Saccharomyces cerevisiae is responsible for complete 5-methylcytosine methylations of yeast tRNA. The incidence of modification depends on the cytosine position in tRNA. At positions 34 and 40, 5-methylcytosine is found only in two yeast tRNAs (tRNALeu(CUA) and tRNAPhe(GAA), respectively), whereas most other elongator yeast tRNAs bear either 5-methylcytosine48 or 5-methylcytosine49, but never both in the same tRNA molecule [1]. The formation of 5-methylcytosine34 and 5-methylcytosine40 is a strictly intron-dependent process, whereas the formation of 5-methylcytosine48 and 5-methylcytosine49 is an intron-independent process [2,3]. 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The intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors [1]. ,384,1.0,-0.058437902,-0.028324582,-0.062008828,-0.08012121,-0.05453632,-0.033984207,-0.014402282,0.030180203,-0.008408806,0.07352154,0.07409325,-0.03982917,-0.089050405,0.01783895,-0.09027536,0.022862237,-0.059722923,-0.03650887,0.022380782,-0.004505321,0.004999312,0.08802217,-0.02490561,-0.0021095208,-0.02444668,-0.040990386,0.019345792,-0.0015903194,0.061665107,0.01570213,-0.07723737,0.060253736,0.09154981,-0.024101319,-0.048388198,0.062099893,-0.09836474,0.008833345,0.076776825,0.0434196,0.041947126,-0.0026929618,-0.037434112,0.016750008,-0.024981305,-0.048083548,0.03316821,-0.019573456,0.004963652,0.037764177,0.041509293,-0.02703372,-0.011196722,0.032893047,-0.04884126,0.030495651,-0.09821243,-0.006579981,0.076676145,0.0046065655,0.016437583,0.008838151,-0.028491635,-0.0025621979,0.13506868,-0.0071713952,0.07422415,-0.03965699,0.0022298116,-0.005111671,0.002048225,-0.04039501,0.015276152,0.032310866,-0.029312978,0.06620271,0.06267897,-0.06263977,-0.045004535,-0.031352762,-0.006925659,0.05573027,0.055420425,-0.005797666,0.008191352,0.07174155,-0.022023713,0.10528238,0.0036020665,0.047953565,0.032318205,0.033054043,-0.011871685,-0.026089445,-0.071419485,0.049983922,0.04807136,0.025599329,0.05864882,-0.05276641,0.02740397,0.050656926,-0.06288781,0.0035610648,0.009600814,-0.007577465,0.021492662,-0.0044388263,-0.039491232,0.013747747,0.015835704,0.04555833,-0.012337715,-0.041491423,0.0112940185,0.017783953,0.022503687,0.003120671,0.060401987,-0.071781516,-0.056517377,0.027439749,0.025974134,-0.02370133,-0.018684253,-0.06583514,-0.10378957,3.0646857e-34,-0.011129008,-0.005349279,0.073015966,0.056291874,0.02999103,0.04390228,-0.015858218,-0.011938572,-0.02745263,-0.06272683,-0.0573184,-0.07473618,0.011368582,-0.01421214,-0.03345311,0.031706367,-0.037236862,-0.062077034,-0.037763774,-0.07276125,0.004517331,-0.0013912363,-0.050074406,-0.06708488,-0.011819152,0.05329713,-0.029457461,0.033257753,0.07106995,-0.024348779,-0.072422825,-0.016862594,-0.020518301,-0.0117013715,0.14040895,0.070312835,0.076369405,0.065857925,-0.037634887,0.08567509,0.05479141,-0.007832615,0.041705694,-0.04998519,-0.032195874,-0.05542263,-0.11383775,-0.0012081431,-0.013111155,0.04407309,0.015634855,0.01847742,-0.015616674,-0.03250114,-0.08260038,0.019234763,-0.0042719245,-0.04290286,-0.012168758,0.06131521,-0.015723843,-0.030554287,-0.033372458,0.11215222,-0.074148595,-0.053864855,-0.07437069,-0.08801874,-0.013810308,0.05579534,-0.036320027,-0.052303527,0.1065267,-0.01596855,0.09292036,0.017367823,-0.03174749,0.01907379,-0.017691104,0.05095262,-0.015720831,-0.0434012,-0.022555936,-0.032083657,-0.023940884,0.017331032,0.058862727,-0.03703424,0.031225342,0.04250874,0.032482747,-0.10140655,-0.018257968,0.020687947,-0.044385448,-3.162736e-33,0.085276105,-0.072977886,0.11919768,-0.10180453,-0.06331342,0.05492066,0.05464903,-0.08667609,-0.10505579,-0.07968036,0.15341188,0.056067403,-0.017858343,0.044094298,0.027496051,0.062068906,-8.008327e-05,0.06343754,-0.009912794,-0.008882838,0.029945761,-0.013420037,-0.10222466,0.08969911,0.054456197,-0.022590749,0.027433494,0.059334,0.023395393,0.02261794,-0.11612749,0.008246277,0.022404304,0.022721382,-0.017617835,0.029988473,-0.04434398,-0.008132892,0.008545078,0.032188963,-0.037275106,0.01338556,-0.073579215,0.07141055,-0.06806153,0.05742895,-0.008217882,-0.023132069,-0.032103907,0.03595584,0.11820613,0.032248106,0.030650994,-0.02009344,0.08896896,0.040207352,0.019450586,-0.018526241,0.041393373,0.009515417,0.0037151314,-0.026921032,-0.023637943,-0.060889427,0.07207262,0.015225199,-0.055029944,0.102058746,-0.032950576,-0.087215364,0.0001891724,-0.015108487,-0.034588028,-0.050021462,-0.08019924,-0.12745479,-0.013052666,-0.04406466,0.03212106,-0.04857765,-0.050919276,-0.02497249,-0.0009399729,0.0031910068,-0.023746755,-0.03115805,0.05680421,0.070449255,-0.0185391,0.06316183,-0.04360742,0.051328633,-0.044591587,0.018525949,0.034151677,-3.6565876e-08,-0.023591433,-0.07834096,-0.049260028,-0.017919337,-0.018736495,0.07548341,-0.047989484,0.007454944,0.076216884,0.015844174,-0.058445722,0.041466057,-0.023273163,0.11188946,-0.031459495,0.050645433,-0.09406855,0.0029260546,0.02072828,-0.045245472,-0.113952786,0.07661141,-0.08366297,-0.023990996,0.00075038936,-0.0070119905,-0.0013381279,0.12939604,-0.026402397,-0.025209814,0.012812441,0.021757003,-0.003799294,-0.0042398158,-0.03399062,0.04972646,0.031812903,-0.046488624,-0.09408806,0.03390613,0.019210821,0.0046004,-0.086940035,0.014501982,-0.036544386,-0.0566705,-0.018327154,0.098726645,0.034672506,-0.040180903,0.023722624,0.05026677,0.040629297,-0.06194518,-0.010774553,0.012470525,-0.021188019,-0.004592796,-0.07538742,0.026464097,0.02061081,0.007947117,0.12555441,-0.05136527 +2.1.1.204,"The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3]. 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+2.1.1.205,"The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe, tRNATrp and, possibly, tRNALeu.",384,0.99999994,0.022585113,-0.07057818,-0.102122135,-0.0653498,-9.9694036e-05,-0.04505599,-0.027566183,0.0139434915,0.016520644,0.044516113,0.054988954,-0.023466408,-0.10138755,-0.059560426,-0.0829582,0.07819876,-0.12302509,-0.033457622,0.09775433,-0.02681199,0.06802408,0.015423497,0.04396664,-0.028234078,0.01592712,0.036266807,0.010270649,-0.020455102,0.044777658,-0.11340688,-0.03500206,-0.0081483545,0.050255228,-0.032266166,0.029376598,0.022313792,-0.009183244,0.018759426,0.055096548,0.037203316,0.056851275,-0.029754546,-0.04002769,0.037230954,-0.0940366,0.00052435667,0.048465252,0.039417055,-0.04559554,0.05961127,-0.025623526,-0.013834428,-0.0067667626,0.01839766,-0.06324772,0.08180208,-0.015302315,-0.020538567,0.01944557,0.0307085,0.034708373,0.0030079572,-0.0008971687,-0.016686283,0.08001325,-0.107341446,0.086576544,-0.037069675,-0.0076252962,0.007968716,-0.0006565203,7.804515e-05,-0.08328487,0.02829154,0.012100702,0.03900574,0.026569761,-0.06463567,0.04825886,0.010700682,-0.015843064,0.0143738575,0.06674812,0.02076976,0.030495826,-0.0077950642,0.01164552,0.09516555,0.07119875,0.07749241,-0.004494091,0.013260462,0.03018554,-0.0092631625,-0.0218794,0.07525438,0.04311041,0.08561874,0.09260904,-0.05199976,-0.0073219677,0.03275683,-0.046131007,-0.045126572,0.029780012,0.01115291,-0.011640473,0.041798253,-0.0043316144,0.032702204,0.014928242,0.0023511434,0.05452258,-0.03637027,-0.033591427,0.024551243,0.023373285,0.0101700835,-0.024420593,-0.03431698,-0.06390008,0.030238396,-0.028533379,0.022760404,-0.08599473,0.010151804,-0.07376479,5.1734925e-34,0.04000704,0.0384504,-0.023768725,0.020594005,0.0475933,0.032851126,-0.037755806,0.06281021,-0.0778517,0.0052826745,-0.069462985,-0.09340908,0.028386567,0.007323029,0.018175695,-0.060165383,0.06702418,-0.0140066,-0.022860872,-0.0996906,-0.036792822,0.04016909,-0.04144961,-0.030431801,0.06024618,0.038335916,-0.026091026,0.052582715,0.051466484,-0.034452453,0.010930891,-0.08729975,-0.068680234,-0.02540962,0.15652779,-0.03703612,-0.01886194,0.010755324,-0.04247102,0.08132314,-0.0261162,0.022115096,0.0033269294,-0.036413606,-0.0064369454,0.03323791,-0.011410848,0.01141873,0.04140504,0.055477872,-0.010222735,-0.007915315,0.039354116,0.007345084,-0.018085156,-0.02245593,-0.042993635,-0.05638161,0.0043398277,0.03826487,-0.056659322,0.034074746,0.013719369,0.05264465,-0.03250016,-0.074372865,-0.048452225,-0.07083851,-0.010111416,0.07443572,-0.047567792,-0.048128534,0.059694003,-0.08786831,0.010983243,-0.017110424,-0.099614024,-0.08975917,-0.023739327,0.032254174,0.017279254,-0.03559424,-0.0029984636,-0.063937426,-0.045445163,0.022037685,-0.028312908,-0.044060636,-0.023111677,0.048788212,-0.04369499,-0.08404448,-0.01334034,-0.013185444,0.061147805,-3.4672543e-33,0.06796034,-0.043221258,0.10246144,-0.10287523,-0.11590781,0.062768586,-0.0078057675,-0.07508783,-0.077964015,-0.03298112,0.048107527,0.013063471,0.008569197,-0.009185079,0.036076244,-0.053927213,0.011509482,0.12499604,-0.019289892,-0.01766645,0.04747947,0.04754493,-0.06155306,0.10812699,0.079572454,-0.028673371,0.072347336,0.079294235,0.046808645,0.036821697,-0.07352922,-0.017293552,0.065526836,0.073071055,-0.009827613,0.06368725,-0.022761753,0.017593736,0.037916664,0.02375171,-0.025090162,0.0063639847,-0.04392601,0.046445724,-0.04291218,0.03843057,-0.027860336,0.037311744,-0.0012528634,-0.07809709,0.100192346,0.016432822,-0.016501151,-0.012218794,0.07400695,0.017853836,-0.113864504,-0.009486223,0.030768326,-0.07232087,-0.008137517,-0.025006024,0.014970404,-0.043876182,0.07612434,0.021476172,-0.055949956,0.03455386,-0.039290164,-0.02550444,-0.026524264,0.04980433,-0.01850466,0.042816564,-0.0042358288,-0.05261857,-0.059802342,-0.069801085,-0.017868085,-0.055533193,-0.024935026,-0.031568483,0.07765169,-0.038782377,0.0047578956,-0.048623122,0.05557145,0.10104404,-0.042087447,0.1193706,0.008022771,0.040655624,0.002893169,0.057987247,0.032603174,-3.345938e-08,0.03091858,-0.055385068,0.029743837,-0.05710081,-0.002805648,0.089923725,-0.003111051,0.041769765,0.04639278,0.045416936,-0.057980567,0.058720157,0.03052654,0.08575366,0.092905454,0.027295606,-0.09983918,-0.03166277,-0.005276181,-0.017652344,-0.0801577,0.029460825,-0.10112732,0.072223514,-0.040443562,0.0020949694,-0.0017895151,0.08905821,-0.008694036,-0.019910086,0.036168803,0.019379843,0.017891075,-0.043660227,-0.031292327,0.040000126,-0.030309774,-0.08633091,-0.06365972,0.018855024,0.014282042,0.014535606,-0.029843373,0.03170743,-0.08937569,-0.042550996,-0.032672632,0.077084735,-0.0396601,-0.009258242,0.04487145,0.017049644,0.009616119,-0.010068345,-0.05916275,-0.044392947,-0.067880124,-0.05593862,-0.103834346,0.02792684,0.031412177,-0.01869832,0.16333655,-0.11657929 +2.1.1.206,The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts. ,384,1.0,0.0019019352,-0.021870043,-0.051819097,-0.048812892,0.022928827,0.032242034,-0.10475108,-0.010198092,0.031299356,0.030332202,-0.010438486,-0.039643377,0.0022340962,0.009175083,-0.038884927,0.015822574,-0.12433993,-0.019187244,0.050136834,-0.0005530269,0.0602112,0.119764075,-0.03655592,0.015229128,0.015291236,0.00830746,0.024483,-0.035562593,-0.035520144,0.017493729,-0.013382528,-0.05448215,0.113466285,-0.0072971587,0.058303036,0.0892279,-0.040241715,0.004477928,0.09408664,0.02762508,0.035733942,0.05213577,0.041478913,0.008248644,-0.00934385,-0.010460382,0.05029451,0.000775794,-0.005535824,-0.026470983,-0.008185065,-0.028610222,-0.056116454,-0.034483317,0.04118318,0.13560538,-0.023479128,-0.02149807,-0.005593001,-0.03880105,0.038011998,-0.047297686,-0.004217096,-0.029014053,0.06825906,-0.092014916,0.06525204,-0.011279804,0.06425054,-0.034262873,-0.040791713,-0.033211328,-0.050703295,0.044658773,-0.039482325,-0.01847152,0.031055367,-0.044019163,0.025041848,-0.05018169,-0.0111206705,-0.077177085,-0.00077216263,-0.048856314,0.029024137,0.01178127,-0.035320148,0.028709397,0.089360625,0.017890917,0.017560285,-0.015077897,0.023269957,-0.10524508,-0.0114322975,-0.012036167,0.030818127,0.067021094,0.005856375,-0.009508448,0.050375067,0.056953505,-0.10478062,-0.024047853,-0.025634402,-0.008051969,0.042420916,0.06707,-0.08244175,0.03013665,0.062419645,0.023529548,0.068387404,-0.006850017,0.030989248,0.095755346,0.043823633,-0.05417868,-0.036974028,-0.028331263,-0.05907362,-0.045501288,0.08027455,0.050397206,-0.034329016,0.025846267,-0.07782648,1.16836555e-35,0.049140938,0.021083111,0.0354725,-0.021644065,0.0517457,0.001518843,-0.057985917,0.02671052,-0.005572991,-0.041780174,-0.14189914,-0.075618125,0.048001822,-0.09771576,-0.06523151,0.0004774862,-0.04400203,0.013462866,-0.009455888,-0.02583888,-0.04238531,0.008153649,0.052397814,-0.029512802,0.022471298,-0.041335944,0.05006294,-0.07808184,0.07007763,-0.00988946,-0.06645683,-0.03678305,-0.07100339,0.006072813,0.098371744,0.0023987365,-0.10011595,0.003273737,0.003310422,0.07144421,-0.003746887,0.028662654,0.046118755,-0.06955811,-0.008155893,0.051200505,-0.049249664,0.05056596,-0.040365193,0.04598123,0.053825352,-0.047075737,0.01211387,0.005171935,-0.098779686,-0.003269251,0.00073532824,-0.070260905,0.03649872,0.07958991,0.0012928667,-0.0032197007,0.023899944,0.052983236,-0.027700093,0.015445127,-0.08414204,-0.034817394,0.037823923,0.13671002,0.019863106,-0.03728646,0.10216721,0.007934265,0.02058243,0.00089243054,-0.08424921,-0.022366373,-0.011065106,0.030161573,0.021547938,-0.015146762,-0.017776843,0.0030092737,0.011500514,0.0037449584,0.02399259,-0.04070074,0.02311165,0.092321776,0.019152356,-0.06525337,-0.011046328,-0.017954838,0.021266181,-7.842817e-34,0.043394018,-0.099029966,0.043395605,-0.10053502,-0.040250912,0.027751433,-0.031105224,-0.100350276,0.0060727447,-0.074478425,0.10478565,0.034611665,0.010267803,-0.011295539,0.044332884,-0.06495293,0.06966614,0.08503768,0.026407838,0.019737728,0.0896135,-0.06688669,-0.052018344,0.04585338,0.07587043,-0.033849273,0.035698332,0.085173026,0.06141484,0.0071787057,-0.03599766,0.047054306,-0.0046444074,-0.019986602,-0.012896356,0.07590156,-0.04320333,0.011685285,0.003603101,0.014097007,-0.00950773,0.08135618,-0.032254703,0.08719157,0.02377888,0.027336633,-0.0466224,-0.0035207162,-0.042047173,-0.07340679,0.08369977,-0.112763666,0.04648197,-0.02538446,0.043041762,0.05343308,-0.051111236,0.06671298,0.008446759,-0.01900669,-0.030909222,-0.0542955,-0.079224266,-0.038080923,0.025780767,-0.025034247,0.0005293373,0.016058365,-0.03975563,-0.0056271795,-0.017449617,-0.04284926,0.025691262,0.0763443,-0.014888843,-0.05525571,-0.08165295,-0.015891919,0.036446497,-0.07255256,-0.060218066,-0.0036586316,0.03711065,0.008033958,0.009248707,-0.060258746,0.07222201,0.10566628,-0.041381612,0.02950362,-0.071837164,-0.006172461,0.018529521,0.003221801,0.015271737,-2.680589e-08,0.031629097,-0.09136715,-0.0014360601,0.0014673682,-0.0136328265,0.12463806,-0.009958899,0.034078144,0.06380705,-0.086473495,0.016012982,0.033773966,0.030414343,0.025239497,-0.0068788324,0.12163117,-0.105030455,-0.023015771,-0.015747745,-0.0058738017,-0.061454397,0.07074655,-0.123236015,0.023437636,-0.034434527,0.0029351835,-0.01856112,0.13190675,-6.7262576e-05,-0.07395527,0.110686,-0.037693817,0.034907777,-0.0020124342,-0.059393447,-0.025033187,0.007101886,-0.04211197,0.033943716,-0.008424582,-0.0035651485,0.03581352,-0.04841948,0.032507457,-0.03867578,-0.0037227813,-0.029144915,0.075978465,-0.04609644,0.035392206,0.05216135,0.027754126,0.048685476,-0.044643294,0.014025028,-0.07723626,-0.012406305,-0.07893637,-0.0563489,0.021707714,0.07275745,-0.028980967,0.13251014,-0.0604161 +2.3.1.193,"The enzyme acetylates the wobble base cytidine34 of the CAU anticodon of elongation-specific tRNAMet. Escherichia coli TmcA strictly discriminates elongator tRNAMet from tRNAIle, which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem. The enzyme can use GTP in place of ATP for formation of N4-acetylcytidine [1]. ",384,0.99999994,-0.07881797,-0.048698723,-0.079297416,-0.098253585,-0.04063611,-0.05129614,-0.02100562,0.057015225,0.047158476,-0.012973115,0.12937085,-0.042095043,-0.029745989,0.039916947,-0.09151449,0.0020549006,-0.026999129,0.09546196,0.096363604,-0.10265905,0.029427908,0.040134996,-0.0016322191,0.037962858,-0.008027718,0.02078772,-0.047877375,0.040080365,-0.025632197,-0.041330874,-0.068800196,0.0062897983,0.11487715,-0.0453017,0.111434035,-0.0034704867,-0.08793877,-0.0046620406,0.12385236,0.021397052,0.026845884,0.051356692,0.055730842,-0.018835394,0.029988525,-0.043051533,-0.029779682,0.028881965,-0.049970448,0.035053115,0.005919331,-0.024868652,-0.020715212,0.044572487,-0.020390905,0.078400135,-0.067932576,-0.0005137518,0.05707325,0.061458424,0.11719587,0.0026286163,0.030330932,-0.0028290928,0.026412638,-0.042324685,0.061306138,-0.024439406,0.06329362,-0.0005719163,0.011155198,0.013312598,0.0016415006,0.066073366,-0.005958338,0.024322942,-0.0003968248,-0.023571245,-0.004968701,0.061781127,-0.017594418,-1.9489826e-05,0.026980493,0.019787284,0.07172415,0.011599206,0.047146853,0.025801526,0.037148733,0.04513361,0.016140293,-0.027881388,-0.022607902,-0.05823901,-0.004606058,-0.01405829,0.03603242,0.0075052762,-0.073981844,-0.044324104,0.00045221316,0.041689113,0.04097709,-0.010122537,0.019117037,-0.008250745,0.026379338,0.033811912,0.0105180945,-0.0388696,-0.029761212,0.02516248,0.034800004,-0.0007130099,-0.041298535,0.04543864,-0.035092514,-0.014208933,-0.013396153,-0.0037005919,0.014578237,-0.114946544,-0.050121017,0.011602664,0.025248427,0.009526258,-0.100343876,5.0069642e-33,0.053893637,0.00022224375,0.015870744,-0.002149447,0.05286074,-0.023695052,-0.06308805,7.5888325e-05,-0.083650835,-0.08629564,-0.05051496,-0.09220097,0.083120845,-0.0057268115,-0.031119702,-0.046563454,-0.09045861,0.026649967,0.041117772,-0.006239664,0.025037654,0.07419716,-0.012961274,-0.030095704,0.0056486214,0.03318833,-0.10503177,-0.029901017,0.060249332,0.046442807,-0.054944456,-0.02956192,-0.08077669,0.006770166,0.123449415,-0.04840434,0.002962328,-0.06711031,-0.016181989,0.051070377,0.013230687,0.05509435,0.03103869,-0.05025229,0.0075763464,-0.042464208,-0.008497469,0.04157932,0.023148652,0.04412245,0.096040085,-0.0326918,-0.018290332,-0.009332271,-0.070289634,0.028574105,-0.025733553,-0.009253186,-0.019023431,0.05957314,0.015475338,-0.0050167954,-0.040507857,0.023619642,-0.04503078,0.003335637,-0.082264565,-0.10298153,0.017594274,0.074894704,0.009263464,-0.088698484,0.0647532,0.049793493,0.07120636,-0.04578553,-0.044808656,0.036939513,-0.0027044164,-0.017540164,0.007924398,-0.013310747,0.00024582958,-0.023581676,-0.07435897,-0.041795153,0.030200534,-0.03385067,0.0510881,0.076760486,0.021807045,-0.06529693,-0.046987437,0.078472674,0.009188525,-5.0026777e-33,0.08246849,-0.10636269,0.06853763,-0.058611766,-0.15105025,0.046697047,-0.04012103,-0.06290606,-0.010639385,-0.099323854,0.12755518,-0.012425573,-0.107128784,-0.0085307835,0.021911915,-0.008738028,0.044181973,0.009492264,-0.071505845,-0.040605944,0.04153899,-0.07942964,-0.017171856,-0.013034435,0.088418685,0.054063234,0.03840619,0.031127032,0.021137882,0.04216536,-0.114742436,-0.012521773,-0.020962559,0.045758817,-0.059254494,0.08692103,-0.023090368,0.005839858,0.05993849,-0.010949444,0.03904144,-0.009373638,0.0145387845,0.051896032,0.00014266517,0.05382871,0.04108786,0.051200572,-0.014524753,-0.006465701,0.07675069,0.010315141,-0.02739035,-0.0044383546,0.06112712,0.058220558,-0.010292979,-0.008344378,-0.1175247,-0.0111838505,-0.022423076,-0.04650231,-0.029101979,-0.011821424,0.105117396,0.03958409,-0.04466689,0.066527866,-0.002318119,-0.0738542,-0.008982585,0.009722074,0.0065951045,-0.025860313,-0.009019261,-0.07268865,-0.039403457,-0.09349981,0.0052953293,-0.09020175,-0.093206495,0.00061269145,-0.0070874547,-0.014501701,-0.043413326,-0.02961492,0.0110043865,0.096801825,0.04097807,0.060420644,0.037420124,0.030818436,0.042255882,0.0110666845,0.0974687,-3.858909e-08,0.026903415,-0.05713462,-0.012418732,-0.03167112,-0.0027295973,0.08643483,-0.009349457,0.050271895,0.08519971,-0.005371487,0.037350427,0.08067301,-0.024774753,0.015229763,0.0021853873,0.04067659,-0.115753464,0.0064548193,-0.029877136,0.001598954,-0.14821991,0.008971989,-0.10124427,-0.02422514,-0.06603924,-0.057793755,0.0053674197,0.08492445,-0.029645922,-0.037332907,0.026672745,-0.014002268,-0.027463462,-0.0116736945,-0.022497905,-0.01344589,-0.0022582759,-0.0454372,-0.03487051,0.047318514,0.003316584,0.024910765,-0.12800719,0.014365766,0.028046472,0.03532159,-0.02435276,0.038087152,-0.01502616,0.0434594,0.0004430774,0.023731662,0.04059753,-0.016511558,-0.04458672,0.011646282,0.028880801,-0.035792332,-0.016148293,0.051061943,-0.037412222,-0.035912495,0.16573685,0.018418932 +2.3.1.194,"The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway. +Unlike the homologous EC 2.3.1.180 (beta-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.",384,1.0,-0.050822575,-0.031192448,-0.090923876,0.007264855,-0.024269832,0.018571453,-0.06886025,0.033434857,0.07882807,-0.07371018,0.028911056,-0.12316354,-0.022161582,0.029323146,-0.091669835,0.013353472,0.03605028,-0.010985838,0.07879226,-0.044921786,0.046953123,0.12819728,-0.041691363,-0.043053925,0.034463644,0.00023713359,-0.048629418,0.04414214,-0.01079561,-0.14068326,0.036291752,-0.018513652,0.06041671,-0.038661998,0.10317229,0.11231984,-0.051391125,-0.077155605,0.088652976,-0.0071885334,0.025473883,-0.07362237,0.03140587,0.053632822,-0.09211604,-0.049392667,-0.011611771,0.023043098,0.056278713,-0.056040227,-0.06307632,-0.05973748,-0.05643793,0.048542555,0.006384497,0.023628403,-0.0054899086,0.06791103,-0.007644035,-0.03607793,0.07164638,0.039096203,0.02648368,-0.02753651,-0.06985574,-0.018645434,0.009838807,-0.07099601,0.026942136,-0.02587466,-0.055167902,-0.08278897,-0.012267453,0.08217504,0.04577463,0.06910346,-0.045723993,-0.056632996,0.021707851,0.0053709853,0.009456932,-0.008799874,-0.054711062,-0.00882563,0.01353715,-0.013192452,0.06583477,-0.0060504572,0.04463557,0.019464273,0.0569221,-0.08312845,-0.052099828,-0.051348235,-0.051597167,0.046487655,0.008146636,0.0005489343,-0.006718441,-0.004649473,-0.04257552,0.032524437,-0.031499695,-0.023197688,-0.05888974,0.02850741,-0.042621236,0.049547777,0.046361286,0.0041842717,-0.025570901,-0.012457177,-0.0035716412,-0.059732158,0.064641744,0.109493956,0.010611015,-0.05988748,-0.013732557,0.011787286,-0.041185886,-0.05427061,0.023762234,0.016093425,-0.0010442121,0.0076350924,-0.059550975,-1.4027012e-34,0.040166214,0.04022471,0.031733736,-0.02102355,0.015312511,-0.09115282,-0.09648307,0.0042007426,0.008656983,-0.11232864,-0.03064399,-0.10941699,-0.004843208,0.03130426,0.016109968,0.012473604,-0.034877624,-0.019805387,0.06557314,0.03883993,0.022853037,-0.03634877,-0.004060214,0.0076546865,0.016304912,0.033513464,0.025663264,0.05630637,0.10639123,0.016241634,0.02513643,-0.014835135,-0.05027907,-0.019696975,0.02329029,0.01676574,-0.05181433,-0.03109808,0.046276588,0.07412562,0.07236653,0.057989337,0.033694368,-0.029169403,0.0972261,-0.08056374,-0.014242339,0.09103388,0.038809385,0.031077027,0.039792158,-0.059036694,0.07345641,-0.016704855,-0.057209883,0.07286479,-0.0337004,0.023564806,0.052509487,0.016307482,-0.022567518,0.060781512,0.026968952,0.05799609,0.018735299,0.015740134,-0.030115334,0.0024437844,0.004590761,0.080430284,-0.020099489,-0.07721639,0.006380184,0.03230015,-0.0453822,-0.048921477,-0.1065543,0.051788837,0.07980027,0.014738373,0.024560126,0.017798131,-0.0599516,-0.0883001,0.013522015,0.044899415,-0.043343313,-0.05824151,0.09428309,0.069843516,0.027236858,-0.04703376,-0.01387425,0.038365845,-0.0841844,-1.1534391e-33,0.12693927,-0.05575856,0.04956444,-0.016587302,-0.062711194,0.05998159,0.05045141,0.00627177,0.006671578,0.032476235,0.06761582,0.057958387,0.029054865,-0.08078996,-0.0015677842,-0.051916175,-0.02328235,0.027584648,-0.016290886,0.039141517,-0.015806437,0.031212743,-0.01781962,0.02836479,0.016780514,-0.02735321,-0.04601764,0.048514485,0.020383248,0.025302416,0.04968506,0.007971078,-0.007256452,-0.09415801,-0.08849545,0.041048363,-0.06482642,-0.0075237304,0.04638451,0.023589255,0.054068554,0.0675198,-0.03589594,0.025041066,-0.0084167095,0.053860374,-0.035241596,-0.0026485547,0.06339196,-0.13955261,-0.0047295387,0.022579363,-0.04427195,-0.03531996,0.0016285015,0.08598892,-0.020696806,0.026970655,0.016876394,-0.045132577,-0.08326162,0.008471954,0.026142325,-0.08068678,0.1111005,0.0922614,-0.02256644,0.029376274,-0.0046188156,0.028251432,0.008137398,-0.048415065,0.057606407,0.016997768,0.0049210745,-0.068002544,-0.06986961,0.04017607,-0.014349169,-0.04872681,0.018922443,-0.030926595,-0.039398596,-0.091720656,-0.020118926,-0.06168681,0.00036764302,0.02322016,-0.0090157995,0.09314917,-0.042418774,0.038988642,-0.01214852,0.015399087,0.108372,-3.9934985e-08,0.07726358,0.002339062,0.09884686,0.022500096,0.06376886,-0.03654562,0.025146637,-0.038309425,0.06378741,0.0738972,-0.13050184,-0.0007465071,0.034899443,-0.015153325,-0.030721461,0.075308345,-0.02461092,0.017828869,-0.024081757,-0.036318958,-0.06681634,0.009439255,-0.032952867,0.016832106,0.080660746,-0.048966434,0.069148965,0.04385056,-0.046619326,0.054821145,-0.022997381,0.03297553,-0.04004181,-0.032978155,-0.05222087,-0.013935898,-0.063720845,-0.043097686,0.009446319,0.055827104,0.040251546,0.06095515,-0.06290115,0.0031213663,-0.028611543,0.055597335,-0.055674776,0.02368997,-0.09395956,-0.0011674323,0.0405019,-0.015985744,-0.03459078,-0.011581907,-0.035063688,0.061487556,-0.0036530944,-0.061495755,-0.0012232664,-0.03982765,0.034952056,-0.03148484,0.1569438,-0.07595568 +2.3.1.195,"The enzyme is resonsible for the production of (3Z)-hex-3-en-1-yl acetate, the major volatile compound released upon mechanical wounding of the leaves of Arabidopsis thaliana [1].",384,0.99999994,-0.084861,-0.056567416,-0.09068033,0.03419238,0.056955636,0.06089103,-0.009755979,-0.01715249,0.019332208,0.01624543,0.043121234,-0.012415535,-0.08151271,-0.055326253,0.033076063,-0.029304959,-0.040962577,0.044712972,-0.08604759,-0.09023974,0.076042645,0.065923356,0.0019285023,-0.021551406,0.09146365,-0.011964132,-0.036275297,0.011135685,0.038158067,-0.11851346,-0.013566748,0.05251698,0.04765922,-0.08858989,0.048874848,0.04332235,-0.013163809,-0.14978327,0.020300187,-0.0006879569,0.06843358,0.03522184,-0.06570368,-0.037667077,-0.08183492,0.0021921392,-0.043792468,0.00537431,0.06900405,-0.059686214,-0.02560734,-0.004338781,0.01460963,-0.035085093,-0.035711747,-0.022985559,0.029375155,0.0007525114,-0.0154130515,0.03292326,0.07996866,-0.021685516,0.00051889475,-0.006165485,0.05688383,-0.03895777,-0.0008959002,-0.08065086,0.025061546,-0.010496099,-0.040930554,-0.059410974,-0.071328126,0.023829183,-0.01602557,0.07218736,0.001128449,-0.05442032,0.019567396,0.022124382,0.06910908,-0.0083122775,0.0219106,0.13721418,0.0037006408,0.048741415,-0.08987279,0.021981178,0.05437267,0.07098018,-0.011696631,0.053449944,0.021372542,-0.008522485,-0.0437343,0.0823592,0.06873951,-0.010290547,-0.03942716,0.008269089,0.08574936,0.06665653,-0.015966445,-0.07339343,-0.060218595,0.0741813,-0.033223286,0.016931666,-0.053082902,0.058310304,-0.039336108,-0.013324716,-0.012943005,-0.08074336,-0.11898503,0.069625214,-0.036145426,-0.04047118,-0.005233909,0.001884544,0.0011379701,0.045324318,0.029422183,0.04311707,-0.0048292778,-0.07904167,-0.061295915,-8.0632135e-34,-0.05926541,0.10481132,-0.08981384,-0.0044631744,-0.06560156,-0.042901687,-0.025120834,0.02361516,-0.037282,-0.049482368,-0.0732299,-0.024405878,0.0075780805,-0.030969052,-0.025586752,-0.005090305,0.016255446,-0.046466228,0.060678996,0.021323599,0.021750927,-0.03099283,-0.109909154,0.043523114,-0.053202115,-0.032895606,0.022055218,-0.02844002,-0.02063102,-0.029296733,0.038242567,-0.0015472304,-0.015032748,-0.0067824763,0.06805629,-0.05192287,-0.039775528,-0.018900868,-0.06117459,0.025494147,0.04967918,0.09372904,0.0103279045,0.024920749,0.0037676394,0.03196034,-0.07695482,0.09277885,0.08334791,-0.039403167,0.07625376,0.051757537,0.15451267,-0.051714744,-0.011409306,0.09374402,0.0398733,0.056318548,0.07313167,0.036013175,-0.058818255,0.067957945,-0.013635034,0.1280401,-0.056675687,0.04379215,-0.11547819,-0.057793375,-0.020528466,0.10449641,-0.080775924,-0.046175156,0.05140833,-0.015059735,0.04955802,-0.031841863,-0.066586,-0.0011590275,0.023413392,0.0060666013,0.008318446,-0.039248273,-0.031537604,0.01447165,-0.07960104,-0.08789116,0.0129052885,0.01247314,0.03121365,0.11427588,0.14818496,-0.081737824,0.01805767,0.00346594,0.007947844,-1.6862274e-33,0.021458633,-0.010113724,0.0371253,-0.07389577,-0.05989666,0.084304616,-0.012200191,-0.0046158778,0.008299929,0.0010063817,0.07511631,0.04431238,0.022460409,-0.04705307,0.03910334,3.516079e-05,0.036466192,0.048311617,-0.016962616,0.009880328,-0.025041224,0.015694046,0.063137814,0.05369631,-0.0143812755,0.0015561932,0.047416344,0.043471225,-0.0042557544,0.02705349,0.041417778,-0.041359592,-0.008558978,0.016007604,-0.040671866,0.010981597,-0.02424412,-0.0051458925,-0.017430265,-0.028641118,-0.008949428,0.01160529,-0.010900627,0.082915895,0.045930862,0.061579406,-0.057208035,0.012995638,0.014535766,-0.008292778,0.058505,0.012312552,-0.067679204,0.024746599,0.08002673,0.02228318,0.058033433,-0.09142525,0.00084746076,0.008615033,-0.023240743,-0.017247414,0.04993018,0.005732379,0.043591995,0.0043438287,-0.014594396,0.04336296,0.012212765,0.040470798,0.059815414,0.096367575,0.01229078,-0.0049831755,-0.009800097,-0.016992973,-0.08658838,-0.025967218,-0.09787039,-0.049403396,-0.010544568,0.048071325,-0.039057735,-0.022990832,0.0008285749,-0.09862584,-0.016386205,0.13294569,0.0026625716,0.014724154,-0.02123597,-0.025028788,-0.062359013,0.044262294,0.070678025,-3.7191636e-08,-0.0370622,-0.04727373,0.06785292,-0.05454832,-0.0082972795,0.050002567,0.0036082389,-0.04414449,0.14446712,0.018985838,0.005847171,0.03573643,0.062401596,0.012652028,0.023313485,-0.049695853,-0.006243472,0.032823738,-0.015230301,-0.07141456,-0.028073108,0.01999977,-0.037672795,-0.017778687,0.04890513,-0.04669126,-0.031548094,0.03497486,0.054013144,0.012924244,0.009232741,-0.003576617,0.047264744,-0.039214216,-0.12677388,-0.03413709,0.036343582,-0.04169244,-0.03255986,-0.032483112,-0.04984495,0.0438996,-0.07908121,0.019750252,-0.07571755,-0.03874214,-0.0019810996,0.030809084,0.015159946,-0.027412698,-0.04060025,-0.0095339,-0.041278847,-0.047741957,-0.03713367,-0.05648063,-0.04998144,-0.014422959,1.8912497e-05,-0.06715142,0.020135256,-0.05054328,0.12592211,-0.00954487 +2.4.1.254,The enzyme is highly specific for cyanidin 3-O-glucosides and UDP-alpha-D-glucuronate. Involved in the production of glucuronosylated anthocyanins that are the origin of the red coloration of flowers of Bellis perennis [1]. 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+2.4.1.255,"Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins. ",384,0.9999999,-0.017950827,-0.06361558,-0.07663743,-0.062132735,0.040517624,0.03487252,0.018604275,0.0418841,0.08772655,0.023454418,-0.012025961,0.019441677,-0.011686672,0.0029262276,-0.04359614,-0.015125153,-0.020289112,0.04899528,0.01718525,-0.059235785,0.09167726,0.021676995,-0.032856505,-0.0070962217,-0.008722107,-0.01702658,-0.04521549,-0.021467054,-0.001123354,-0.10594329,-0.086314075,-0.07193862,-0.0054012127,0.02860666,0.01699981,0.08018652,-0.03600497,-0.035340935,0.0009646644,-0.0431517,0.04434375,-0.008311657,-0.06943027,-0.045057464,-0.02190632,0.022564128,0.045767408,-0.016896177,-0.019472672,0.03686178,-0.009682387,-0.04916162,-0.07521078,0.051175494,0.041595466,0.023595573,-0.083438545,-0.0120985005,0.081272736,0.056588415,-0.054867834,0.07473826,0.0058142166,-0.049947895,0.083076075,-0.07317251,0.08988786,-0.018644977,-0.037933443,-0.0010807754,0.016706746,0.00819822,0.038658578,0.066706784,0.020914078,0.029990396,-0.1224182,0.058673717,0.019155392,0.03246137,0.086614735,-0.0069338195,0.013676027,0.09717324,-0.024562467,-0.025476187,-0.011950888,-0.0073646884,0.14297087,0.014979232,0.04256931,-0.078750744,0.034294613,0.0042543975,-0.049416162,-0.067975715,0.02354656,0.046355102,0.014293211,-0.0016293391,0.05204711,0.057610724,0.026843533,-0.039663896,0.0015575665,0.046181224,0.057042632,0.07369178,-0.018536972,-0.0015687125,-0.0062426627,0.025832264,0.029147953,-0.013543466,-0.104539536,0.08494253,-0.007198726,-0.08282899,-0.08165061,-0.042239554,-0.0071294494,0.05078602,0.073658586,0.07800904,-0.034421716,0.03527994,-0.05242625,3.1756678e-33,0.0410819,0.05855222,0.09350504,-0.021997135,0.0068531022,-0.05707558,-0.051052716,-0.0037615323,0.07137512,-0.12517455,-0.045774728,-0.004333621,0.043419253,0.030484786,-0.013929244,-0.027367465,0.0011079347,0.012967687,0.08577305,0.03312306,0.00027719722,0.026821708,0.021491772,0.009934251,-0.005477044,0.041234046,-0.07135032,-0.006381236,0.046811692,-0.0013292646,-0.023449756,-0.08523059,-0.033097498,0.029392093,0.058207836,-0.037831955,-0.027813623,-0.087078735,0.05858526,0.001203178,0.02684507,-0.012549453,-0.085998885,-0.0124359755,0.014973704,-0.044672545,-0.047722116,0.049632642,-0.085326865,0.008088973,0.007120053,-0.08110435,-0.00406513,-0.007144263,-0.08269275,0.035628706,-0.041678425,-0.0718935,0.037528608,0.08444086,0.055468522,0.0001663142,0.03144972,-0.02027203,0.042152364,0.018692534,-0.16975605,7.297498e-05,-0.008297032,0.06264392,-0.02710514,-0.085273616,0.080162756,0.05655247,0.039370093,-0.07757577,-0.10023168,0.041387804,-0.026393594,0.02365045,0.08852767,-0.021547476,-0.054413885,0.04280241,-0.07787393,-0.002651537,0.10133641,-0.031208629,-0.056756265,0.05418296,0.05456825,-0.1004556,0.0029506166,0.041178185,-0.0109279575,-3.9451772e-33,0.079706706,-0.0761991,0.0864289,-0.017771985,-0.050213348,0.01669398,0.046520244,-0.029465273,-0.017626297,0.002578243,0.043883055,-0.06886627,0.023860468,-0.025578182,-0.033378344,-0.114689864,-0.03339374,0.05005093,0.009337881,0.0041027893,-0.056194585,0.014652554,0.00013761633,0.046863195,0.041153383,0.0067264982,-0.03408838,0.07750179,0.0063632634,0.071548164,-0.029726233,0.041304816,-0.031491425,0.01413056,0.0009887776,0.039214052,0.060366385,0.03569778,-0.010933124,-0.013587122,-0.024168005,0.03857169,0.024092685,0.008697466,0.08204706,0.14536227,-0.023751343,0.00022494045,-0.04360305,-0.068028115,0.09360724,0.0123990625,-0.05565383,-0.032684825,-0.0156248715,0.034681227,0.050733246,-0.0013652651,0.017245015,-0.0862837,-0.03345771,-0.07177175,-0.025488243,-0.026794683,0.09629812,0.002149382,0.00592171,0.059730828,0.036670487,-0.01577685,-0.025511034,-0.023448061,0.08980085,0.008296389,0.033273097,-0.014456413,-0.04729634,-0.034418225,-0.024455318,-0.10705492,-0.087375514,-0.049470324,0.024863048,-0.081641264,-0.010323274,0.028525084,0.072803356,0.08530449,-0.04968819,0.05630067,-0.096370004,-0.017915456,-0.07541458,0.079898745,0.025909113,-4.280227e-08,0.035807006,-0.015210701,-0.026730457,0.03829695,0.0032649713,0.029914549,-0.05618228,0.03622703,0.045174688,-0.015952133,-0.0335296,0.06522679,0.061475262,-0.014089392,-0.031926885,0.04371826,-0.017470438,0.039043587,0.0031936206,-0.012594507,-0.0718456,0.030810487,-0.07602774,0.03415685,0.031567875,-0.064232275,0.07821967,0.06470699,-0.029096043,-0.103714146,0.014686519,-0.014915988,0.01351365,-0.04715824,0.022434823,-0.006698747,-0.022194939,-0.05499953,0.039589696,0.049001545,-0.0027427475,0.08736275,-0.103625104,0.018484663,0.046458606,0.025769925,0.05892982,-0.0008979318,-0.087731294,0.023141721,0.057626616,0.008427665,-0.010071253,-0.08876137,-0.04979021,-0.052657165,-0.06823588,-0.041150246,0.030792702,0.009684541,-0.00569966,-0.032014683,0.11840624,-0.047844373 +2.7.7.73,"Binds Zn2+. The enzyme catalyses the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine. +The enzyme shows significant structural similarity to ubiquitin-activating enzyme [3,4]. In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide [2].",384,1.0,-0.09231948,0.0071673,-0.0946394,0.025020653,-0.02048804,0.004586392,-0.013143284,0.019686753,0.02009831,-0.07489546,0.029936165,-0.03452048,0.03380092,0.0779689,-0.05865638,0.02026741,-0.058246218,-0.014448101,0.010442669,-0.06547079,0.05539828,0.13364507,-0.04137908,-0.038971737,-0.018875886,-0.01742431,0.07765741,-0.009632769,0.009698555,-0.06347418,-0.05876779,-0.052900515,0.00719035,-0.06339019,0.02947819,0.060488462,0.014113586,-0.017212883,0.030785404,-0.054943237,0.09234011,0.049564324,-0.019842137,0.02802755,-0.025758186,0.008247214,0.04276161,0.03768572,-0.003037608,0.046795376,-0.08409337,0.0075586997,0.041241173,0.057870213,0.065795735,0.03308844,-0.08809401,-0.026022485,0.03502467,-0.019654425,0.043749522,-0.01746059,0.024633937,-0.03232609,0.087159,-0.06444331,0.016178297,-0.06377757,-0.022647534,-0.060104396,-0.07380184,-0.0012885542,0.015103543,0.009619643,-0.016770322,0.037849065,-0.02237076,-0.058738098,-0.0044115796,-0.03839072,0.03919398,-0.012806633,0.10521681,0.13058133,0.05245833,-0.032733675,0.028359976,-0.0035233812,-0.02752423,0.05510793,0.044483162,-0.0081146145,0.02998725,0.0028567554,-0.09531164,0.0050810976,0.0125674,0.046858557,-0.020974152,0.023364231,0.060893588,0.04282614,-0.04338673,-0.06414527,0.011537024,0.023038441,0.06742721,0.08780024,0.020728333,0.069652185,-0.029688219,-0.0021456461,-0.0027587973,-0.06149038,-0.04639353,0.081174135,-0.021255005,-0.008925455,-0.08176445,-0.07259238,-0.04661745,0.048677657,-0.014814704,0.065973856,-0.011356818,-0.04727042,-0.18748528,2.9727521e-33,0.08041444,0.060599092,0.017866895,-0.0040803305,-0.0040929904,-0.0130150905,-0.069901936,0.069890805,-0.027587043,-0.042850934,-0.07721066,-0.107092865,0.01674726,0.0009812368,-0.034276057,-0.07960443,-0.019656243,-0.015185632,0.065837964,0.032147825,-0.00052050775,-0.02053908,-0.05626204,-0.03752999,0.026455238,0.047135282,0.02612681,0.036751557,0.020940121,-0.005152131,0.055889916,-0.08827612,-0.12632093,-0.016626362,0.12317317,-0.0580874,-0.031568553,0.038578387,-0.05246785,-0.0097093815,0.008537425,0.02756787,-0.068106286,-0.047799975,0.06261653,-0.04296573,-0.055082943,0.112967975,0.0016909112,0.0022019737,0.041164536,-0.045226984,0.07786085,-0.05038475,-0.08487512,0.021401826,0.003586172,0.024458464,0.016182793,0.009187178,0.03401647,-0.02618129,-0.082570344,0.07890554,-0.06726539,0.08694745,-0.07244255,-0.04338305,0.031665444,0.07748367,-0.04388295,0.001983715,0.09138956,0.02954197,-0.03252906,-0.008894668,-0.08394234,0.005477806,0.08618226,0.018406976,-0.01212747,-0.045766264,-0.027141973,-0.03541549,-0.038888723,-0.086211555,-0.030385856,-0.04547754,-0.012224529,0.06032895,0.02126141,-0.09352673,-0.039053775,0.059341043,0.060785964,-4.5056206e-33,0.11831088,-0.025457405,0.09719505,-0.10931375,-0.015555424,-0.0068456237,0.0036583566,0.00045090503,-0.02427377,-0.039270174,0.0972044,0.041288298,0.068775505,0.024621408,0.020021709,0.053948738,0.00872498,0.04187673,0.05066167,-0.042856526,0.016129175,0.005388506,-0.017722338,-0.04786257,-0.024734786,0.03864379,0.05178912,0.073480606,0.082987756,0.05020383,-0.06693744,0.0026188444,-0.06317551,-0.066456184,-0.111345895,0.06562085,-0.025529087,-0.020824792,0.036004696,-0.051937707,-0.0059585413,-0.039402667,-0.048822086,0.0987006,0.05567279,0.10774639,0.019129232,-0.044014283,-0.027219396,-0.07174287,0.049891654,0.016415825,-0.031788375,0.005050643,0.007830588,0.08731188,0.038715467,0.019832648,0.054156788,-0.06099222,-0.015287376,-0.028157257,0.053329665,0.0041782726,-0.0696283,0.0019187395,-0.0002723472,0.025013123,0.055662133,-0.053373367,0.044883084,0.008676161,0.02931813,-0.02225129,-0.081719354,0.0050614728,-0.028791815,-0.027169945,-0.0074948347,0.01732113,-0.021918625,-0.024964724,-0.0364274,-0.022735013,0.013798424,-0.011294331,0.088368274,0.104295686,-0.047163464,0.0029366962,-0.06191658,0.034494475,-0.0089177815,0.010883309,-0.04451516,-4.206259e-08,-0.019687848,-0.12181805,0.0036016363,-0.040372543,0.00097187,0.078272134,-0.045346588,0.04623985,-0.0017970542,-0.021216234,-0.0028132014,0.08344223,-0.041154202,0.035638064,0.062414177,0.012071249,-0.022924434,-0.04305265,0.016316127,-0.012869816,-0.0650856,0.028970754,-0.06874123,0.06043327,-0.0025422869,-0.06183539,-0.01854407,-0.035468005,-0.01667497,-0.06201802,0.04868972,0.03737408,0.010193162,-0.073535554,-0.06672495,0.00989656,-0.018686494,-0.09060008,0.010012285,-0.020605747,0.058869794,0.05262268,-0.042599592,0.026647914,0.03141249,0.026627319,0.020414552,0.105154924,-0.07033055,-0.001511876,0.004596682,-0.057598118,-0.02380463,-0.0829017,0.00034289522,0.034578558,0.018885281,-0.0573587,0.0020965056,0.05234848,0.041768122,-0.01745797,0.108488545,-0.041898195 +2.7.8.32,Mn2+ required for activity. The enzyme is specific for mannose as an acceptor but is flexible as to the structural context of the mannosyl disaccharide. ,384,1.0,0.0325351,-0.062080227,0.004550736,-0.009644211,0.057846334,0.031199561,0.008357812,0.03467318,-0.054221883,0.09337941,0.05711139,-0.029631168,0.0043342523,0.03667815,-0.01204857,0.04204321,-0.025035176,-0.02798118,-0.014085579,0.026962863,0.11543988,-0.020538831,0.007023412,-0.06455661,0.06453068,-0.018122535,0.013392318,-0.0845199,-0.02033764,-0.08520813,-0.036773972,-0.013451264,0.067970164,-0.044994272,0.048924163,0.089110635,0.0583688,-5.7128647e-05,-0.011992316,-0.06823286,-0.0071844957,-0.055560563,0.069950126,-0.037358396,-0.05821184,-0.045285515,0.022939073,-0.037717365,-0.0123890685,0.07091231,-0.053266827,-0.011777588,0.007795457,0.022541856,0.0046428596,0.05672895,-0.08168452,0.021726828,-0.037706293,-0.034595072,0.014733938,-0.050202288,0.024405213,0.0013989192,0.06160734,-0.051606566,-0.0033356538,-0.079987414,0.015663529,0.01676983,0.025273068,-0.051159196,-0.048616037,-0.05729247,0.058603417,-0.037542876,0.038183365,-0.039681528,0.07556904,0.002389907,-0.031791016,0.041055363,0.11362703,0.026936984,0.013763916,0.060059812,-0.0028795744,0.004014172,0.043453623,0.012510408,0.012916109,0.020793404,-0.010497064,0.020684164,0.018670632,-0.024911204,-0.0388588,0.058393788,0.051914897,0.009936643,0.04103173,0.04215394,-0.060722366,-0.08457901,-0.0021487528,-0.0009940745,0.024333,-0.0006847261,0.027612915,0.026904043,0.07204077,0.058905598,0.0101264,0.057543837,-0.038932193,0.052372698,0.0700399,-0.12131238,0.002132158,-0.047807302,0.016937824,0.021739112,0.0011331512,0.0074665253,-0.07150083,0.031192074,-0.057437185,-2.6574913e-33,0.002261752,-0.011847779,0.052249618,0.0011084952,0.045438405,0.0018790112,-0.036541995,-0.043353055,-0.009536161,-0.041248467,-0.13989171,-0.07920447,-0.0063953623,0.13779695,-0.058886643,-0.009353061,0.014724599,-0.015705021,0.091371946,-0.010146494,-0.012080958,0.057984166,-0.038957126,0.00960293,0.034513913,0.0627973,0.058472786,0.012323307,0.043748755,-0.018531192,0.10504462,-0.11508763,-0.06407085,-0.01251692,0.050416023,0.03185033,-0.048069045,0.01930115,-0.009283868,-0.03486655,-0.012885952,0.064242534,-0.07070774,-0.012133577,0.03484338,-0.05971945,0.008963662,0.0163338,-0.036100894,0.037606012,0.04918049,-0.0060490705,0.027933681,0.0043238597,-0.016361695,0.05619879,-0.0036764091,0.015919993,0.055598952,0.07294925,-0.03390884,-0.017981656,0.0268835,0.030015007,0.050464187,0.039198563,-0.052189767,-0.03567,-0.0029512933,0.027810523,-0.06178045,-0.1226697,0.051504854,0.022367576,0.0052900612,-0.07101531,-0.049186535,-0.022229524,0.040146243,0.040714107,0.040280554,-0.02781609,-0.023750776,-0.014069067,-0.14408931,-0.026343046,-0.017272117,-0.16738579,0.00021923686,0.05279793,0.023893883,0.036270157,-0.12409607,0.059907626,0.024573995,-1.0928808e-33,0.09360468,-0.047625896,0.08122732,-0.05323729,-0.07461626,0.026278725,0.047892716,-0.12215729,0.09843402,-0.014327877,0.09552406,-0.016580764,-0.01628278,-0.014412089,-0.018085008,0.022919117,-0.015612456,0.086840734,0.0063731046,0.07215077,-0.04363844,0.153766,0.0037566246,0.0027605656,0.063433774,-0.008471941,-0.032225467,0.061067186,0.023544341,-0.02286427,-0.046150647,-0.024934918,-0.017719395,-0.108039714,-0.035532,-0.011220606,-0.121661074,0.0059528043,-0.00889771,0.020774605,-0.04894306,0.042346332,-0.0015198665,0.047807097,-0.03618181,-0.0056959246,-0.052731056,0.016774094,-0.08419307,-0.010798056,-0.0045622704,-0.04462985,0.0063881474,-0.023419686,0.09400895,0.07319586,-0.017038979,-0.008172167,0.019063056,-0.016645906,-0.052657682,-0.017554099,0.03350482,-0.015601934,0.019898603,0.072983116,-0.056132123,-0.0032006782,0.027055735,-0.0057525956,-0.0053449664,0.025926482,0.068132825,0.04091381,-0.009781274,-0.06849183,-0.12822857,-0.031679783,-0.0030748532,-0.08823384,-0.07887243,0.042387225,-0.013834611,-0.0951355,0.022648957,-0.032499943,0.045418177,0.089718066,-0.00082122383,0.0678758,-0.021154093,-0.0686955,-0.05664044,0.06223752,0.027364966,-2.8009344e-08,-0.00067116844,-0.05846453,0.034150116,-0.11341408,-0.06862602,0.018206876,0.0329427,-0.041269187,0.00937069,0.016653774,0.041246653,0.08281072,0.0068766815,-0.024070261,0.012972709,-0.0052445224,0.026325626,0.021204473,-0.07408117,0.008528066,-0.06917572,0.028877903,-0.10727486,0.08338782,0.045251925,0.026821297,0.013830872,0.05404874,-0.04171627,-0.015613766,0.03551191,0.08591222,0.036194842,-0.07073026,-0.09930466,0.08562891,-0.013473824,-0.052908584,-0.022337735,-0.021765126,-0.026753584,-1.14487e-05,0.04700769,-0.030763863,-0.06901238,-0.0009861356,-0.053234976,0.0569262,-0.027109072,0.027142184,-0.004223678,-0.034372028,-0.076964326,-0.058933377,-0.04666992,0.06553006,-0.011714752,-0.033218686,-0.017346982,-0.056230154,0.06040283,-0.021156447,0.080223195,-0.13509864 +3.1.7.7,Isolated from the plants Valeriana officinalis (valerian) and Persicaria hydropiper (water pepper). The enzyme does not act on farnesol or drimenol diphosphate. Using 18-oxygen labelled water 18-oxygen was incorporated suggesting involvement of a stabilised carbocation or an equivalent species.,384,1.0,-0.049024425,0.022166336,-0.116792105,-0.02243711,0.08156719,0.03231186,-0.101604395,0.057963405,0.070852526,-0.12684332,0.067291304,-0.076692484,-0.07217963,-0.0034775347,-0.07377008,0.08784383,-0.041928682,0.06009055,0.011918745,0.017119773,0.007153897,0.07492982,0.019815864,-0.034736678,0.01757586,0.08851839,0.02838786,0.06176432,0.028526494,-0.102729544,0.02256868,0.0670797,0.0972413,-0.09641706,-0.01159286,0.098741576,-0.039759587,-0.038476173,0.048534177,0.04849659,0.020395612,-0.032732993,-0.00014197834,-0.06613705,-0.025919428,-0.046274785,0.001910066,0.051124837,0.009543813,-0.02667595,-0.023193136,-0.055292714,-0.05708885,0.028460998,-0.0599869,-0.05679931,0.009393088,0.041028783,0.0034793771,0.030647743,0.06495671,0.054713957,-0.0113483025,-0.0084129935,-0.0901577,-0.019397028,-0.033323843,-0.03665341,0.09132819,-0.116423674,0.0069775786,-0.061690032,0.0483102,-0.036388773,-0.105253525,0.055804636,0.038875807,0.06913076,0.09850515,-0.056963038,-0.053166438,-0.010112564,-0.025511963,0.034008447,0.016001852,0.06430304,-0.040022157,0.032127786,0.025245106,0.017793695,-0.003180189,0.035442244,-0.039004132,-0.012145563,-0.0407911,0.026929231,0.06320569,-0.017824937,-0.023297267,-0.0034590673,0.017121295,0.064049646,-0.09682064,-0.08613847,-0.01874725,0.017947594,-0.028121052,-0.040259477,0.0782931,-0.088967614,-0.012023335,-0.0018202603,0.015232325,-0.015551841,-0.0052355863,0.025444392,-0.0029499517,-0.0477016,-0.045014065,-0.008004255,-0.08920125,-0.05066415,-0.021470753,-0.02490724,0.030523943,-0.018165328,-0.08580259,4.4866456e-33,0.03529214,-0.0090656895,-0.005109712,0.0024764598,-0.019546004,-0.06269089,-0.034374926,0.045652036,-0.033147875,-0.026227755,-0.08557361,0.025025047,-0.03788541,-0.04273382,0.009963022,-0.026509754,0.069147885,-0.0463282,0.06990152,-0.05410787,0.03618609,0.045144632,-0.07699237,-0.02679099,0.00667501,0.0653877,0.07256787,-0.056906715,0.059819505,-0.026502145,0.02700368,-0.110608965,-0.004652434,0.005655539,0.05692943,0.055886786,-0.07313747,-0.015293272,-0.07058343,0.025340015,-0.04627294,0.08024678,-0.024105169,0.020192912,0.06645328,-0.057490863,-0.060755413,0.057175342,0.100457646,0.04682592,0.017982312,0.010267488,0.09155382,0.049568802,-0.088538714,-0.0055585224,-0.05518022,0.066388585,0.0079697985,0.015252978,-0.004843193,0.099899895,-0.01319993,0.004289824,0.03767013,0.052150693,-0.13618237,-0.041553397,0.058517918,0.062317185,-0.04510336,0.020763582,0.041866448,-0.05313983,0.027360832,-0.02654359,-0.009816088,0.0005664007,0.049797166,0.0074990992,0.05754475,-0.0055142376,0.06445642,-0.012885372,-0.063824765,0.024898084,-0.038842365,0.031974804,-0.0032064721,0.15230855,0.027136842,-0.056083836,-0.027638588,-0.038624626,0.038376857,-3.775653e-33,0.07335457,-0.07308903,-0.0069331788,-0.041904382,0.036016293,0.08090114,-0.066162504,0.0038710337,-0.049158942,-0.032091007,0.0074869115,0.012727944,0.09060532,-0.027264673,-0.008863653,0.07085418,0.03265682,0.11252787,-0.024336277,0.010010595,-0.09719461,0.074936196,0.002497362,0.009838007,-0.034005135,0.020870453,0.07722367,-0.055443443,-0.03819071,0.015558659,0.10968346,0.007280182,-0.011070411,-0.05716319,0.0406191,0.008733498,-0.0730547,-0.019667549,0.02549369,0.05309981,-0.062561415,0.0029523855,-0.01855414,0.096283585,0.027318602,0.02110246,-0.059307914,-0.039354507,-0.06386429,0.050993606,0.0473024,-0.005759106,-0.030107489,0.027818594,0.032351892,-0.05116896,0.013013421,0.004108154,-0.031689588,-0.045973793,0.0005511388,-0.09069309,-0.024968699,0.023591343,0.031225193,0.083428994,-0.01660276,0.10308145,0.0014041818,-0.0024759558,0.07146201,-0.0034313027,0.04006863,0.08174978,-0.006737674,0.030679794,0.049755413,-0.071485445,0.02035462,-0.038797278,-0.03342611,0.011385537,0.016980434,-0.068994276,-0.030368462,-0.081498556,0.041766055,0.0078871725,-0.00044310515,0.060332682,0.05992429,0.014884212,-0.054101333,-0.017577607,0.16885205,-3.7620264e-08,-0.024176752,-0.073173195,0.025651854,0.055601683,-0.040678695,-0.012797048,0.048822027,0.012245179,0.0012744145,0.014943636,0.010679508,0.0297425,-0.0047271694,-0.07163118,0.063800216,-0.025946476,0.08795596,0.06163321,-0.036295786,0.01976531,-0.060502436,0.016566832,-0.040079724,-0.026594676,0.013455703,-0.08740929,0.030655647,-0.056519695,0.034068063,-0.033981007,0.0963036,0.057309702,0.0029688645,-0.051644854,-0.009944722,0.031013079,0.019483479,-0.033242848,-0.048271507,0.035729494,-0.012387314,-0.023368793,-0.05484599,-0.0018428776,-0.022058992,-0.010335395,0.000555764,0.00030809653,-0.015217842,0.01885292,0.02983532,-0.006760904,0.06643787,-0.08779227,-0.058357257,-0.0014552398,0.028250953,-0.014719728,-0.05433821,-0.042330384,-0.048446313,0.013272635,0.113682285,0.0039732098 +3.2.1.169,"Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins.",384,0.9999999,-0.017950827,-0.06361558,-0.07663743,-0.062132735,0.040517624,0.03487252,0.018604275,0.0418841,0.08772655,0.023454418,-0.012025961,0.019441677,-0.011686672,0.0029262276,-0.04359614,-0.015125153,-0.020289112,0.04899528,0.01718525,-0.059235785,0.09167726,0.021676995,-0.032856505,-0.0070962217,-0.008722107,-0.01702658,-0.04521549,-0.021467054,-0.001123354,-0.10594329,-0.086314075,-0.07193862,-0.0054012127,0.02860666,0.01699981,0.08018652,-0.03600497,-0.035340935,0.0009646644,-0.0431517,0.04434375,-0.008311657,-0.06943027,-0.045057464,-0.02190632,0.022564128,0.045767408,-0.016896177,-0.019472672,0.03686178,-0.009682387,-0.04916162,-0.07521078,0.051175494,0.041595466,0.023595573,-0.083438545,-0.0120985005,0.081272736,0.056588415,-0.054867834,0.07473826,0.0058142166,-0.049947895,0.083076075,-0.07317251,0.08988786,-0.018644977,-0.037933443,-0.0010807754,0.016706746,0.00819822,0.038658578,0.066706784,0.020914078,0.029990396,-0.1224182,0.058673717,0.019155392,0.03246137,0.086614735,-0.0069338195,0.013676027,0.09717324,-0.024562467,-0.025476187,-0.011950888,-0.0073646884,0.14297087,0.014979232,0.04256931,-0.078750744,0.034294613,0.0042543975,-0.049416162,-0.067975715,0.02354656,0.046355102,0.014293211,-0.0016293391,0.05204711,0.057610724,0.026843533,-0.039663896,0.0015575665,0.046181224,0.057042632,0.07369178,-0.018536972,-0.0015687125,-0.0062426627,0.025832264,0.029147953,-0.013543466,-0.104539536,0.08494253,-0.007198726,-0.08282899,-0.08165061,-0.042239554,-0.0071294494,0.05078602,0.073658586,0.07800904,-0.034421716,0.03527994,-0.05242625,3.1756678e-33,0.0410819,0.05855222,0.09350504,-0.021997135,0.0068531022,-0.05707558,-0.051052716,-0.0037615323,0.07137512,-0.12517455,-0.045774728,-0.004333621,0.043419253,0.030484786,-0.013929244,-0.027367465,0.0011079347,0.012967687,0.08577305,0.03312306,0.00027719722,0.026821708,0.021491772,0.009934251,-0.005477044,0.041234046,-0.07135032,-0.006381236,0.046811692,-0.0013292646,-0.023449756,-0.08523059,-0.033097498,0.029392093,0.058207836,-0.037831955,-0.027813623,-0.087078735,0.05858526,0.001203178,0.02684507,-0.012549453,-0.085998885,-0.0124359755,0.014973704,-0.044672545,-0.047722116,0.049632642,-0.085326865,0.008088973,0.007120053,-0.08110435,-0.00406513,-0.007144263,-0.08269275,0.035628706,-0.041678425,-0.0718935,0.037528608,0.08444086,0.055468522,0.0001663142,0.03144972,-0.02027203,0.042152364,0.018692534,-0.16975605,7.297498e-05,-0.008297032,0.06264392,-0.02710514,-0.085273616,0.080162756,0.05655247,0.039370093,-0.07757577,-0.10023168,0.041387804,-0.026393594,0.02365045,0.08852767,-0.021547476,-0.054413885,0.04280241,-0.07787393,-0.002651537,0.10133641,-0.031208629,-0.056756265,0.05418296,0.05456825,-0.1004556,0.0029506166,0.041178185,-0.0109279575,-3.9451772e-33,0.079706706,-0.0761991,0.0864289,-0.017771985,-0.050213348,0.01669398,0.046520244,-0.029465273,-0.017626297,0.002578243,0.043883055,-0.06886627,0.023860468,-0.025578182,-0.033378344,-0.114689864,-0.03339374,0.05005093,0.009337881,0.0041027893,-0.056194585,0.014652554,0.00013761633,0.046863195,0.041153383,0.0067264982,-0.03408838,0.07750179,0.0063632634,0.071548164,-0.029726233,0.041304816,-0.031491425,0.01413056,0.0009887776,0.039214052,0.060366385,0.03569778,-0.010933124,-0.013587122,-0.024168005,0.03857169,0.024092685,0.008697466,0.08204706,0.14536227,-0.023751343,0.00022494045,-0.04360305,-0.068028115,0.09360724,0.0123990625,-0.05565383,-0.032684825,-0.0156248715,0.034681227,0.050733246,-0.0013652651,0.017245015,-0.0862837,-0.03345771,-0.07177175,-0.025488243,-0.026794683,0.09629812,0.002149382,0.00592171,0.059730828,0.036670487,-0.01577685,-0.025511034,-0.023448061,0.08980085,0.008296389,0.033273097,-0.014456413,-0.04729634,-0.034418225,-0.024455318,-0.10705492,-0.087375514,-0.049470324,0.024863048,-0.081641264,-0.010323274,0.028525084,0.072803356,0.08530449,-0.04968819,0.05630067,-0.096370004,-0.017915456,-0.07541458,0.079898745,0.025909113,-4.280227e-08,0.035807006,-0.015210701,-0.026730457,0.03829695,0.0032649713,0.029914549,-0.05618228,0.03622703,0.045174688,-0.015952133,-0.0335296,0.06522679,0.061475262,-0.014089392,-0.031926885,0.04371826,-0.017470438,0.039043587,0.0031936206,-0.012594507,-0.0718456,0.030810487,-0.07602774,0.03415685,0.031567875,-0.064232275,0.07821967,0.06470699,-0.029096043,-0.103714146,0.014686519,-0.014915988,0.01351365,-0.04715824,0.022434823,-0.006698747,-0.022194939,-0.05499953,0.039589696,0.049001545,-0.0027427475,0.08736275,-0.103625104,0.018484663,0.046458606,0.025769925,0.05892982,-0.0008979318,-0.087731294,0.023141721,0.057626616,0.008427665,-0.010071253,-0.08876137,-0.04979021,-0.052657165,-0.06823588,-0.041150246,0.030792702,0.009684541,-0.00569966,-0.032014683,0.11840624,-0.047844373 +4.2.3.55,"The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene. The second step is the isomerization to (S)-beta-macrocarpene (cf. EC 5.5.1.17, (S)-beta-macrocarpene synthase). The enzyme requires Mg2+ or Mn2+ for activity.",384,0.99999994,0.0020374027,-0.018757068,0.0012028228,0.067665495,0.010624373,0.025289724,-0.04825808,0.023526117,0.0396839,0.024602512,-0.014748767,0.017938945,0.019473847,-0.07542521,-0.027677754,-0.006034424,-0.035913482,0.06742779,0.023200234,0.068303,0.051624764,-0.035390213,0.031645793,-0.011530612,0.08159878,0.04263112,0.08399895,-0.052400287,0.0028376544,-0.038419403,-0.0018226551,-0.0016489715,0.04381475,-0.10119012,-0.0019821296,0.024523359,-0.013548436,-0.002791169,0.032092836,0.0048346976,0.04420851,-0.021153461,0.06550781,-0.056245476,0.03567454,0.002553599,0.0038211194,0.010998447,0.027501076,-0.03287906,-0.02029375,-0.16455992,-0.07647349,-0.013483801,-0.002550184,0.0061441273,-0.07507965,0.015882913,0.051468052,0.08895287,0.07233633,0.024269879,-0.025750447,-0.0030505618,0.009613844,-0.057205476,-0.03148846,-0.07337171,0.04342959,-0.0365168,-0.13354032,-0.04514374,-0.07794633,-0.005607579,-0.04956596,-0.020236626,-0.009272798,0.07248169,0.036043793,-0.061123107,0.07005753,-0.09483985,0.035795875,-0.007448445,0.04417167,0.069858484,0.027472522,0.048463188,0.049117867,0.04968617,0.06455503,0.07474789,-0.049295735,-0.040789012,-0.0499232,-0.0063298577,0.0023806514,0.09090858,0.022771765,0.030329,0.06131632,0.057169326,-0.02139739,-0.095205456,0.017550498,0.020014152,-0.051279236,-0.021019166,-0.01102259,-0.07226473,-0.010426561,-0.0043943357,0.06538426,-0.004890708,-0.016501704,0.057497654,-0.016239872,-0.063293286,0.022496257,0.023638356,0.011728359,0.010568424,-0.008294539,0.079720974,-0.052478496,0.009328862,-0.029984625,7.016048e-34,-0.0027960888,0.13618168,0.049730346,0.05101578,-0.092153214,-0.007378617,-0.016138202,-0.00417204,-0.04177958,-0.0015117306,-0.007875634,-0.036912907,0.008967899,0.058821183,0.0595189,-0.017328804,0.0420446,0.031159073,0.13713823,-0.10147182,-0.039656665,0.0030748802,-0.031936377,-0.024952928,0.06175208,0.044380587,0.018711371,0.007947459,0.077310644,-0.02121997,-0.004486851,-0.07480797,-0.027267518,-0.014330817,0.019779317,-0.056364655,0.0029292372,-0.049399115,-0.077531315,-0.023602912,0.02391181,-0.05683991,-0.09962206,0.024287561,0.042402234,0.0075005544,-0.03495819,-0.0010458925,0.09351832,0.02657054,0.027109474,-0.016106019,0.029995594,0.068663,-0.11287225,0.051201526,-0.045519803,-0.01491568,0.022910811,0.039819084,0.0037368177,0.043250628,-0.027874105,0.0071847313,-0.009281917,0.06462389,-0.09753206,-0.025517741,-0.06356141,0.067169614,-0.0050771073,-0.030670673,0.102405585,0.0012834766,0.008539111,0.03822834,-0.06678363,-0.029291254,0.04630245,-0.054118525,-0.010099334,0.026378665,-0.05838467,-0.034721166,-0.029144144,-0.012052906,-0.008975729,-0.041938122,-0.006778398,0.11457122,0.026691124,-0.089651905,-0.07574107,0.079744846,0.007918416,-1.814063e-33,0.06376809,-0.021706158,-0.025672866,-0.06773409,-0.035393223,0.0031821853,0.012014573,-0.1443941,-0.01433785,-0.049327385,-0.019499127,-0.040597074,0.08134178,-0.05240318,-0.04216464,-0.07329869,0.0556776,0.032378964,0.0058410554,-0.022549052,0.023178613,0.0073798345,0.07962442,0.09622515,-0.034788623,0.014250708,0.072039545,0.058753278,0.10072641,0.14069624,0.025202695,-0.016187133,0.028503876,-0.0055137,-0.12077691,0.10342048,-0.044751495,0.049977202,0.07140573,0.05287464,-0.045755345,-0.051970858,-0.088895835,0.013853325,0.13403349,0.037667606,-0.014382238,0.01812941,0.00936711,-0.1095934,0.0765653,0.026498422,-0.018415567,0.00015312417,0.009261765,-0.0060029477,-0.058524493,-0.04800782,0.06057204,-0.091479644,-0.026029512,-0.062593654,0.0314496,-0.11998526,0.046220023,0.07389054,-0.019170485,0.063852474,0.0035167132,0.021595294,0.036733236,0.03576369,0.0073427525,0.059160016,0.022874326,0.04749599,0.07528648,-0.08401128,-0.011339263,-0.05846113,-0.074931145,0.021585798,0.003465371,-0.04868405,-0.07177519,-0.08482297,0.019548094,0.061268847,0.05950549,-0.0075376914,-0.03793641,0.025152883,0.0023370497,0.06947565,0.039254814,-3.817428e-08,0.08101063,-0.057568476,0.047932915,0.00155714,-0.014421705,0.036319084,0.046350826,-0.009038556,-0.017159693,-0.03293421,-0.09173996,0.042045467,0.034103725,0.054855302,0.0606043,0.014378699,-0.055818323,0.024114732,0.00013680695,-0.0570218,0.01330174,-0.0019488819,-0.01952448,-0.00839298,0.017313618,-0.12918499,0.010409116,0.028602744,-0.0632867,0.01759114,0.07953887,0.013228775,-0.043879777,0.051534627,-0.03525075,0.029372025,-0.020334125,0.013335497,-0.0014042807,0.03217467,-0.04476089,-0.024879184,-0.077299915,0.037276957,-0.08126161,-0.0090205455,0.030992944,0.002255441,0.0057781073,-0.016056368,0.024963722,-0.022051651,-0.08530928,-0.08445782,-0.027176749,0.010415926,-0.031499833,0.0020663608,-0.037589926,-0.064248964,-0.032095216,-0.021430371,0.09609412,-0.021402912 +4.2.3.57,"Widely distributed in higher plants, cf. EC 4.2.3.89 (+)-beta-caryophyllene synthase.",384,1.0,-0.042716052,-0.088209584,-0.09775316,0.022845972,0.044380758,0.10747761,-0.071561225,0.014787486,0.039279032,-0.009481673,0.011747942,-0.0164455,-0.060985427,-0.056463193,-0.042783733,-0.025962666,-0.099597044,0.011858135,-0.067871936,-0.021879315,-0.06206986,0.026046744,0.008782392,0.060264315,0.023347005,-0.06782848,-0.068364866,-0.064149775,-0.017658243,-0.076115064,0.00095613976,0.0936124,0.074443884,-0.044676583,0.075735256,-0.01792746,-0.011615966,-0.11870434,0.014936517,0.04006882,0.07085266,0.00199456,-0.0018358238,-0.0031515218,-0.039141465,0.013884302,0.010293664,0.030366529,0.03866836,-0.08870095,-0.046635102,-0.026197655,-0.024739636,-0.027775774,-0.011865293,-0.00042760043,0.090767704,0.027949909,0.010824884,0.05486525,0.060640827,0.041202307,-0.027482802,-0.051434007,-0.03261141,0.0052662566,-0.047472302,0.000629405,0.07829803,-0.037511498,-0.072609134,-0.044351228,-0.045116074,0.081093304,0.029551744,0.02331153,-0.015291248,-0.04605128,0.06321813,0.020663464,0.002913501,0.030447584,-0.040100727,-0.060648084,0.018734641,0.031682555,-0.010130724,0.05995174,0.017506275,0.057238527,0.027186727,0.015979799,-0.03862063,-0.012069568,-0.09962567,0.110629655,0.043793432,-0.092525624,0.053809997,-0.049346626,-0.007675165,-0.028687118,-0.043110654,-0.083130665,-0.056660816,0.020265127,0.050355136,0.0013439308,0.012276643,0.004477712,-0.0336235,0.009315485,-0.04948713,-0.052613515,-0.012534199,0.046103153,0.067468785,-0.044502098,-0.06494266,0.0024188291,-0.021823548,-0.050158966,0.0302847,0.077479064,-0.0943922,0.0664212,-0.13784738,-3.7738783e-33,0.084077574,0.06895731,0.052612323,0.038815632,-0.026515068,-0.0060602296,-0.09932469,-0.025426975,-0.0925949,-0.05026903,-0.05500395,-0.06694565,-0.006017954,0.012841127,0.009467812,-0.045837134,-0.028227169,0.05327063,-0.006525584,-0.046382137,-0.012429837,-0.0076550664,-0.09224435,0.030696472,0.050489604,-0.011075295,0.03325643,-0.043354597,0.09737854,-0.031636257,0.021716308,-0.021706345,-0.031316217,-0.03000143,0.014240623,-0.05715998,-0.06398187,-0.064191505,0.006618782,0.11960046,0.095404014,0.060413506,0.08240804,-0.0009184139,0.09487664,0.056516547,-0.04443772,0.039986584,0.07048774,0.014188911,0.006831158,0.023252102,0.05298642,-0.002603813,-0.0044958955,0.04979187,-0.027445382,-0.021823745,0.065561615,0.029514171,-0.038951494,0.085176885,-0.04911665,-0.08403256,0.017500311,0.071639545,-0.07902467,0.012608111,0.023257047,0.051706806,0.0064995787,-0.09883227,0.013613621,0.0011828877,0.09283321,0.039044283,-0.06987157,0.09355292,0.027659545,0.004153196,-0.033733137,0.072594516,-0.025180917,-0.046969824,0.03346445,-0.02487333,-0.0380104,0.052526213,-0.023898352,0.09047145,0.13808616,0.009031905,0.015343996,0.004127317,-0.037386533,2.355307e-33,0.04156161,-0.017184703,-0.039612584,-0.06789036,-0.030131863,-0.051672406,-0.078430794,-0.1038652,0.07522097,-0.018472962,0.014533386,-0.0002021758,0.120539814,-0.03959995,-0.048316963,-0.07590244,0.06889226,0.06285205,0.012044154,-0.008635241,-0.03432359,-0.03351257,0.09739479,0.04659664,0.0041561397,-0.05705866,-0.016032528,0.08940412,0.11646001,-0.016429821,0.051195204,-0.012180997,-0.041782394,0.050149433,-0.054135412,-0.0387,-0.04439519,0.02367339,0.024510236,0.012869116,-0.0062636854,-0.011186355,-0.012072768,0.014874312,0.059131775,0.03676617,0.016437022,-0.019327156,0.019117903,0.06678282,0.019503124,-0.053444218,-0.028188135,0.035745956,0.00051874924,-0.0002576612,-0.005903328,0.07895965,0.00965243,-0.0653332,0.031731702,-0.02989761,0.043868404,0.0070407228,-0.005420522,0.12824027,0.045324884,0.08359731,-0.03276299,-0.019387258,0.08273282,0.036757965,0.012403663,0.07094985,-0.09284045,-0.022545954,-0.029858915,-0.091538526,-0.015640879,0.01198576,-0.048010822,0.05972211,-0.041837744,-0.060242414,-0.029342685,-0.012965812,0.02689763,0.027953386,0.06685572,0.039045326,-0.011945234,0.018189464,-0.020167397,-0.0018668977,0.066062875,-2.7010989e-08,0.0094862105,0.01694772,-0.0055084336,-0.025989592,-0.016122904,-0.039509512,0.05055404,0.011021995,0.057793263,-0.012302865,-0.028077517,0.00808023,0.06713744,-0.040511563,0.12310302,-0.042666525,-0.034796007,-0.007796733,0.0073271873,-0.00222411,-0.004478803,0.05869966,-0.036759466,0.013084949,-0.07443728,-0.05379143,0.04711064,0.014914604,0.034596376,-0.0330106,0.11529088,0.04507054,0.005983975,0.0046741483,-0.04327729,-0.032771457,-0.0057159527,0.04998926,0.012606926,0.022322036,-0.012176546,-0.10099548,-0.030693281,0.0150006395,-0.004926143,0.006642455,0.023550278,0.0015593241,0.058235683,-0.010671372,0.093418464,0.0021335068,0.050397016,-0.040715184,-0.04553846,0.029871777,-0.06176921,-0.018028578,-0.0044821403,-0.04860727,-0.08308548,-0.08610664,0.13205744,0.050867956 +4.2.3.58,"As well as 61% longifolene the enzyme gives 15% of alpha-longipinene, 6% longicyclene and traces of other sesquiterpenoids.",384,1.0,0.053598817,-0.06746409,-0.09026835,0.0023831658,0.03034502,0.008386334,-0.070454225,0.11913085,0.0064623407,-0.039282154,0.053303495,0.003973594,-0.047382876,0.015484339,-0.016041825,-0.015703741,-0.053403225,0.007837476,-0.06939628,0.004032207,0.028326975,-0.05901348,0.020965673,0.028426941,0.08188894,0.014835287,-0.0036899613,-0.013510041,0.024264624,-0.07117674,-0.0050760694,0.014011333,0.11831414,-0.09650675,0.025955189,0.026032338,-0.105034314,-0.072757296,0.045077067,0.016969776,0.066952735,-0.027671082,-0.003951404,0.030309208,-0.099847324,-0.035174493,-0.023789037,0.056121483,0.042888198,0.14972918,-0.019618144,-0.06945369,-0.074923486,0.050255485,-0.007056886,-0.04968374,-0.041000247,-0.0027314627,-0.03646795,0.08382034,0.029539483,0.0013083665,0.009250861,-0.006508216,0.005146736,-0.037098452,-0.011016386,-0.051051904,-0.012443564,-0.010832551,-0.047611,-0.022844242,-0.054336388,0.022770617,-0.046766195,0.03170492,-0.02838099,-0.022266533,0.021103319,-0.09233487,0.060900033,-0.028561462,0.06331519,0.13517307,0.095316894,0.052973483,0.0102804955,-0.02308578,-0.032291036,0.06952745,0.11269695,0.0045295567,-0.028838864,-0.10317941,-0.0021060233,0.03925711,-0.017687771,0.031256203,-0.101316445,-0.033971347,0.038088746,0.045311067,-0.073137,-0.0651718,-0.10109738,0.04834496,-0.032546498,-0.03818866,0.026990779,0.017840488,0.03235996,0.010447054,0.051187847,0.033302654,0.0223129,0.057872977,0.033714958,-0.013418658,0.015082421,-0.0106238155,-0.011991349,-0.033256836,0.072371244,0.045570277,0.0031778829,0.07661428,0.02445399,4.4435806e-33,-0.010810575,0.058348555,-0.021228792,0.027370255,-0.055777982,0.034810238,-0.051321816,0.13797757,-0.058845457,-0.051774222,-0.11076675,-0.020451946,0.039633542,0.03306444,0.017267812,-0.028742975,0.01684209,0.039947286,0.035291016,-0.056440726,0.027085248,-0.04199296,0.0010866689,0.02717401,0.07799291,-0.062805995,-0.04265212,0.10661324,-0.0047924025,-0.027928019,0.0007882352,-0.017983595,-0.02362006,-0.01491092,0.021963337,-0.032676753,0.0047483533,-0.019410644,-0.07502315,0.086442046,-0.005912766,0.023532327,0.052535385,-0.029833514,0.0077574155,-0.065658055,-0.06424984,0.036359306,0.07591716,0.06504271,0.007035421,-0.0035183206,0.047450867,-0.025520055,-0.043158103,0.023316022,-0.04167824,0.0120442435,0.02131259,0.083149865,0.0027162912,0.087037645,0.013951242,-0.020937467,-0.026497366,0.134957,-0.11673309,-0.048033755,-0.034693647,0.08443247,0.014375764,-0.021115236,0.051886585,0.019466074,0.03250698,0.00094801263,-0.08022594,0.07093994,0.039453954,-0.023087608,-0.040214024,-0.08936785,0.0013365584,-0.017221443,-0.056897987,-0.05186317,0.006990921,-0.07147669,0.012323932,0.02329119,0.09785244,-0.11371705,-0.07201774,-0.021126606,-0.05220664,-4.043266e-33,0.010891979,-0.10709312,0.02880225,-0.023042062,-0.024585776,0.10125695,-0.011608206,0.023439076,-0.008752933,0.030116724,0.09364558,0.036169223,-0.036056373,-0.079675496,0.037318375,0.023643468,0.030371072,0.05209302,0.012066526,-0.011662664,0.024227066,0.023981852,0.018427221,0.09663278,0.030557608,0.02299351,0.019937644,-0.08163282,0.008710171,0.075394966,-0.04534911,-0.029052636,-0.06483804,-0.012663426,-0.09245716,0.014743027,-0.04032413,0.0073452564,0.004762794,-0.0028869053,-0.034918953,-0.025186647,-0.0066061993,0.057715386,0.08804381,-0.037268236,-0.10762414,0.04139476,0.024379743,-0.028232284,0.07258928,-0.0052794,0.011819628,0.07330795,-0.0015859787,-0.011502123,-0.04879437,-0.022083743,-0.043984205,-0.03372496,-0.03724061,0.008549079,-0.02829006,-0.045790203,0.08801613,-0.018251399,-0.026889661,0.06495007,0.055621635,0.003211265,0.033082277,0.015168648,0.016706241,0.042224675,-0.015883125,0.008090892,0.063544855,-0.09215275,0.05157417,-0.0048255823,-0.09845169,-0.010626689,-0.04153337,-0.060321018,-0.081919804,-0.04345398,0.048862875,0.06932342,0.0539418,0.0635093,-0.0046488144,0.018892854,-0.038512535,0.020508142,0.11237848,-3.004002e-08,0.090821564,-0.037001222,0.051509235,0.0069011347,0.041058563,0.020775974,-0.0056948517,0.04024755,0.018789155,0.037388884,-0.048365775,0.1216672,-0.019358102,-0.0069273277,-0.0072984747,-0.075334266,0.003311675,0.013935821,-0.045970354,0.014928735,-0.021798203,0.0040828167,-0.07388287,0.0005691431,0.007765715,-0.08646045,-0.05075573,0.025709344,-0.030094985,0.010263099,0.051818307,-0.03325721,-0.027712952,-0.05304751,-0.035510805,0.029463656,0.027222296,-0.053156428,-0.02746015,0.10714054,-0.028781088,-0.09401358,-0.04760732,0.0051247897,-0.0069907177,-0.010125571,0.00081263477,-0.027625175,0.009698026,0.028262513,0.04579945,-0.04050564,-0.054640353,-0.023918018,-0.05641204,-0.018250948,-0.03004051,-0.030418145,-0.031071745,-0.055656187,-0.0069981203,0.006680252,0.20280752,-0.0050448915 +5.4.99.19,"The enzyme is specific for uridine516 in 16S rRNA. In vitro, the enzyme does not modify free 16S rRNA. The preferred substrate is a 5'-terminal fragment of 16S rRNA complexed with 30S ribosomal proteins [1].",384,1.0,0.039310355,0.0118144145,-0.10340837,-0.11566378,-0.013239695,-0.00785407,-0.10417878,-0.004139615,-0.016722377,-0.0037681563,0.036982924,0.014736387,0.02049475,0.15362328,-0.046935514,0.015503193,-0.0544063,0.06407299,0.0083548,-0.007618683,0.044968255,0.052174073,-0.015047595,-0.018194608,0.0086518,-0.014518014,0.06958277,-0.0058430913,-0.05898575,-0.073857695,0.031285595,0.05090507,0.018836187,-0.056892637,0.037098873,0.0024292804,-0.13010456,-0.013505135,0.047290947,0.026036559,0.028221536,-0.0034300128,0.028975528,-0.0036949771,-0.008478535,-0.01234602,0.006314216,0.097297266,0.07527883,0.004381965,-0.06399236,0.0136216385,-0.018338807,0.047115393,0.05977539,0.0019468187,-0.08176061,-0.077331625,-0.06935487,-0.043646973,0.038430654,-0.07924637,0.017414704,-0.073164426,-0.03140909,-0.01507878,0.005058459,-0.045250565,0.012520933,-0.082258426,-0.013936236,-0.04355485,-0.019536732,0.0061737113,0.0029475512,0.010375292,0.015027386,0.03023521,0.018496389,-0.017236756,-0.027136827,-0.088644944,0.041342113,-0.00259903,0.07778218,0.053297088,0.09753879,-0.006453218,-0.0012324285,0.006951849,0.06853289,0.011404304,-0.0012589152,-0.028219515,-0.06604889,-0.059254814,0.013273779,0.039472844,-0.045115832,-0.064997345,0.056359667,0.018308487,-0.042864922,-0.030388381,-0.057669923,-0.025757799,0.06504535,0.114659674,-0.054628436,-0.026925473,0.037872642,0.03737876,0.026992315,0.027445825,0.0294729,0.032485276,0.0057040807,-0.0568873,-0.074261986,0.034644358,-0.053612426,0.02753487,0.034902234,0.0047608563,-0.06079406,0.026177255,-0.08645414,2.6581309e-33,0.038706493,0.10419243,-0.073297136,-0.014909335,0.023861669,0.07478287,-0.019771017,0.014837251,-0.04123178,-0.13616493,-0.16260679,-0.06066839,0.013649225,-0.046408504,-0.06775449,0.001741548,-0.0064809946,0.004897364,0.015681662,-0.016568732,0.0023974578,0.095681526,-0.040543653,-0.008489149,0.032881897,0.037034005,-0.0033398648,-0.0794663,0.036479905,-0.0011442337,-0.016228942,0.021031922,-0.14309765,0.03329172,0.03844294,0.038239505,0.012107941,-0.032768283,-0.046863467,0.0067957374,-0.045244277,0.03626393,0.004342512,-0.006353761,0.035189968,-0.070856735,-0.0219007,0.09745079,-0.024382362,0.077569745,-0.0015809311,0.059223294,0.08146348,-0.03840106,-0.09616902,-0.048542406,-0.036999594,-0.0074684373,0.06633972,-0.0072100936,-0.0072803465,0.024104394,-0.0045171576,0.09197027,-0.021885365,0.016592372,0.0027116707,-0.08258629,0.029565178,0.12831128,0.01564652,-0.026816785,0.08697792,0.03084084,0.020602312,-0.037022978,-0.04938151,-0.013077602,0.08277357,0.060809202,0.01705683,0.0016280893,-0.008292278,-0.007575765,-0.017617835,-0.014796183,0.038743407,-0.026360355,0.0090492265,0.03776335,0.105029196,-0.06724178,-0.032633692,0.006282328,0.107908584,-3.284079e-33,0.142363,-0.13161062,0.08796645,-0.005711929,-0.028256359,-1.9768284e-05,0.03575501,-0.04512242,0.017347043,-0.071851864,0.11624943,-0.010296386,0.012769657,-0.054488372,-0.0024464226,-0.04599041,-0.0063135633,0.090284474,-0.0015109145,0.007291517,-0.036204852,0.044034813,-0.035725977,0.01473696,0.02040508,0.00059752696,0.047799297,-0.020804767,0.051403716,-0.032514986,-0.027266439,0.042146813,-0.035880085,-0.020344496,-0.029416312,0.1209143,-0.01617428,0.0058848704,0.0021369944,-0.009392739,-0.003198823,-0.0064453348,-0.07049422,0.09785804,-0.030327,0.012987423,-0.015524505,0.042557765,-0.0057436638,-0.067474626,0.043802403,-0.019945847,0.056658056,0.014559218,0.08125116,-0.0156086655,-0.015901826,0.04122169,-0.013518037,-0.002782533,-0.037361596,0.0018157985,-0.04965466,-0.013723702,0.03206178,0.025936862,-0.042028576,-0.0239511,0.012028602,-0.0129204,0.0367413,-0.051321205,0.040570773,0.05679013,0.008247546,-0.055282496,-0.062013973,0.010804347,0.012027483,-0.061468363,-0.028949285,-0.017610276,0.0019433594,-0.009917745,0.012179752,-0.0906977,0.08607852,0.065157585,-0.034527518,0.05349472,0.035054,-0.031177232,-0.054377835,0.024790263,0.064633295,-3.4082973e-08,0.09454303,-0.027770646,-0.004418909,-0.070193954,0.008246259,0.05296144,-0.011116589,0.06426701,0.053279217,0.05200182,0.096950404,0.002278563,-0.023159511,0.037817523,0.08232661,-0.0047812792,-0.026396455,-0.009870233,-0.008005111,-0.0011101897,-0.062182162,0.025654001,-0.08873534,0.0319776,-0.008948832,-0.0043914616,0.015165359,0.0031857425,-0.048859805,-0.121031456,0.07422793,-0.045482684,0.030626064,-0.011774424,-0.07767495,0.081039086,0.039537538,0.041743077,0.06867878,0.009241567,-0.013047474,-0.10625631,-0.07446557,-0.021215204,-0.060980927,-0.050212402,-0.061860085,-0.060257632,-0.08098818,0.002243658,0.027331578,0.06534345,0.07587141,-0.06962993,-0.02537498,0.07967058,0.017004676,-0.099968016,-0.012925872,0.0064192014,0.07075001,0.0145804295,0.067498915,-0.098037854 +5.4.99.20,The enzyme modifies uridine2457 in a stem of 23S RNA in Escherichia 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+5.4.99.21,"The enzyme is not completely specific for uridine2604 and can, to a small extent, also react with uridine2605 [1]. 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+5.4.99.22,Pseudouridine synthase RluB converts uridine2605 of 23S rRNA to pseudouridine. ,384,1.0,-0.037297644,-0.01874082,-0.1317786,-0.019122366,0.039513208,0.035160713,-0.09765155,0.041701898,-0.023365919,-0.007137235,-0.007576385,-0.021867298,0.010242773,0.080578074,-0.058610395,-0.06518761,-0.09766777,0.05471993,0.043434266,-0.06437263,0.035543997,0.109013245,-0.049436077,-0.0023163036,0.0063453377,0.040845748,0.043331955,-0.054322246,-0.039485637,0.0053519807,-0.00067332527,-0.0579981,-0.0010396614,-0.06987089,0.030099638,-6.4584114e-05,-0.11381678,0.03733473,0.10969718,0.03305569,0.035028197,-0.0061739604,0.023259897,0.02121927,0.050384007,-0.013115859,-0.046906892,0.05686162,-0.008717824,0.04734422,-0.1118238,0.0068081617,-0.054253887,0.036918472,0.07502339,0.021277724,-0.087714925,-0.037627663,-0.05509341,-0.0066779233,0.03513393,-0.06640805,0.031063508,-0.11959079,-0.011429101,0.01633815,0.0027793653,0.00035988772,0.0905796,-0.04455799,-0.06227134,0.033612754,-0.008091905,0.04855618,0.007549626,-0.02442986,0.031390313,0.018060923,0.0044455444,0.038282186,-0.0028202687,-0.08790932,-0.0146186855,0.008830794,0.043968,-0.02636852,0.106681675,0.018981766,0.04690323,-0.017013518,0.04080151,-0.032855824,-0.08765921,-0.03286024,-0.11008149,-0.010232391,-0.07408554,0.029230487,0.01888908,-0.070385344,0.024249451,0.02457243,-0.07779287,-0.08194563,-0.06264807,-0.018973252,0.038478736,0.0834538,-0.024602959,0.007893386,0.05803246,0.048774637,-0.0068914597,-0.01009148,0.01845711,0.07517731,-0.05535628,-0.04845398,-0.051022638,0.0257108,-0.042968646,0.025417194,-0.012032441,0.0327224,-0.06343922,-0.03296737,-0.09554086,5.126335e-33,-0.035561617,0.10659964,-0.012972706,0.04989568,-0.023128351,0.10110584,-0.045822352,0.009180759,0.08605002,-0.09629157,-0.039095722,-0.025765445,0.016706899,-0.049214274,-0.0728037,-0.016775182,-0.017250288,-0.0023778202,0.005729208,-0.036353458,0.034808666,0.16618204,-0.065820254,-0.0126704015,0.0045314357,0.0050270837,0.017654916,-0.08263135,0.07919768,-0.016392108,-0.046746545,-0.026450278,-0.06782579,0.01937744,0.03869217,-0.026440239,-0.010058871,-0.06914038,-0.0035931545,0.05672127,-0.016056644,0.036352232,-0.015662378,0.034014236,0.080066286,-0.033830132,0.0020693073,0.12272611,-0.042299822,0.09190018,-0.060365606,0.023798903,0.07939912,0.02157029,-0.09076759,-0.06432319,-0.03468189,0.0030146565,-0.0034045242,0.036868114,0.066167876,-0.0016525867,0.04187156,-0.0020171346,-0.0054875575,0.03718427,0.032417115,-0.102482624,0.08952373,0.05788606,-0.0035695815,0.009372798,0.07242807,0.0175473,0.01187869,-0.014972222,-0.047742087,0.08037509,0.056245137,-0.038138498,-0.066923,0.054986052,-0.004014774,0.03571508,0.0021344004,-0.027210869,-0.001797863,0.008538517,0.040252686,0.032684267,0.109551236,-0.09557987,-0.05366379,0.05746362,0.017443387,-3.2745504e-33,0.11946082,-0.06379894,0.023842406,0.01711869,0.004551528,-0.056570504,0.0030646988,0.0022960845,0.030784324,-0.035323065,0.08204408,-0.009930845,0.051952783,-0.026975647,-0.05296658,-0.06396531,0.096398704,0.018132383,-0.024361128,0.008923235,-0.00060114055,0.045675837,-0.00062782597,0.11734127,0.032749057,0.099054724,0.061390918,0.04920392,0.0589464,-0.006589489,0.023287991,0.0119486265,-0.060292304,-0.069199525,-0.035777908,0.11878249,0.053185143,0.07516312,-0.039696176,-0.01755482,0.04288604,-0.009357751,-0.06762241,0.08421141,-0.057067666,0.015915222,0.026941756,0.001126281,-0.025556976,-0.086417004,0.01967614,-0.042191494,0.0017259778,-0.02843753,0.011286626,-0.032815434,-0.06460094,0.025230547,0.011234572,0.006350724,0.006062046,-0.034725178,-0.0055549336,-0.040794168,-0.054400396,0.026227236,0.0051596235,0.04795174,0.056936514,0.019310903,0.014635116,0.008748705,0.07766913,0.059196547,-0.019816509,-0.08109081,0.002089029,-0.05598746,0.055172373,-0.031077763,-0.039761625,-0.07094033,0.031314608,-0.013589868,-0.0006938944,-0.04269306,0.05218305,0.06861056,-0.01842403,0.046172086,0.006741553,-0.017681995,-0.024145596,0.021933133,0.042944845,-2.2445297e-08,0.07059516,-0.051825516,0.042168442,0.03435468,-0.020490736,0.06178633,-0.007863984,0.044754066,-0.009388564,0.048745945,-0.040485255,-0.054374263,0.03594848,0.0007127644,0.012259546,0.069597974,-0.04384773,0.054577686,0.009817779,-0.062044274,-0.05152656,-0.031781815,-0.08662217,0.020227868,0.023678573,0.0053713983,-0.0024247016,-0.014702952,0.026676476,-0.118961155,0.048808515,-0.08949432,0.0773257,0.03930166,-0.050153617,0.079594076,0.098263696,0.024782717,0.031041991,-0.022766424,-0.049608413,-0.05719988,-0.094860435,0.0467544,-0.034827225,-0.072959214,-0.016274106,0.004631928,0.00904495,-0.07754624,0.030222522,0.005901582,0.05129304,-0.054702885,0.0013293483,0.011484573,-0.047136433,-0.04206123,-0.01776267,0.092761405,-0.009686975,0.0224604,0.09553143,-0.011782405 +5.4.99.23,"Pseudouridine synthase RluD converts uridines at positions 1911, 1915, and 1917 of 23S rRNA to pseudouridines. These nucleotides are located in the functionally important helix-loop 69 of 23S rRNA [1]. 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+5.4.99.24,"The enzyme converts uridines at position 955, 2504 and 2580 of 23S rRNA to pseudouridines.",384,1.0,-0.008415256,-0.01992728,-0.1520607,-0.060527638,-0.010083659,0.009994034,-0.09249829,0.061965294,-0.0065459716,-0.0012807796,0.0057479516,-0.02885647,-0.019399978,0.0748653,-0.07091642,-0.022380223,-0.08946099,0.04479789,0.024169287,-0.021242633,0.0788378,0.087566875,-0.023332518,-0.0002775666,-0.017159095,0.02894778,0.04739446,-0.041628446,-0.028634243,-0.054661438,0.0039541423,-0.058202498,0.012079233,-0.05413024,0.05912879,0.015589462,-0.11748645,0.010314281,0.075772226,0.04352422,0.06767739,0.0003992248,0.018314699,-0.026267467,0.00024711908,-0.00845562,-0.028942874,0.062248416,0.04370218,0.035016693,-0.100059606,0.02268616,-0.034976747,0.045408145,0.027181793,0.029670894,-0.07699004,-0.06345406,-0.06518014,0.0005507095,0.045541048,-0.029500969,0.007354477,-0.08788522,-0.019209132,0.0051429174,-0.011347689,-0.053525086,0.051728535,-0.09695323,-0.076536015,-0.0008671529,0.00902846,0.03299179,0.00015494345,-0.050413158,-0.0025539456,0.0015550466,0.01327641,-0.008443117,-0.0026745677,-0.10941675,-0.009380884,0.04011601,0.039300628,0.0075852307,0.057499822,0.056564257,0.065526135,0.0056937966,0.06442495,-0.019100685,-0.030431546,-0.03317897,-0.08580613,0.005780933,-0.031402,0.04013748,0.031573698,-0.05419261,0.0639354,0.009123133,-0.08204759,-0.09095643,-0.052361283,-0.03452017,0.048536576,0.123733416,-0.005247316,-0.018563675,0.015695775,0.041276336,0.04602242,0.028571183,-0.024762547,0.076418236,-0.012188146,-0.039044134,-0.031153541,0.0037575846,-0.025868632,0.038843494,0.026844025,0.058313884,-0.04258991,0.03221453,-0.076908,1.642691e-33,0.014742319,0.11134433,0.015731236,-0.0005728348,-0.04322674,0.08549568,-0.044399146,-0.013841921,0.059567377,-0.118203685,-0.097488075,-0.011611621,0.010618583,-0.009243017,-0.04960612,-0.053582475,0.0053108293,0.028657885,0.033733465,-0.008628668,0.078404024,0.17697735,-0.060467646,0.0041878726,0.014149242,0.051464643,-0.014363899,-0.039364103,0.041171763,-0.004670353,-0.041231494,-0.022978898,-0.09692886,-0.010037906,0.06247897,0.055187218,-0.010323547,-0.054597832,-0.028543077,0.07427201,-0.023510925,0.02567037,0.030027086,0.03627324,0.049769245,-0.04288232,-0.014333631,0.10278124,-0.01781291,0.12938465,-0.055284515,-0.016537173,0.054090835,0.036856484,-0.102580294,-0.07889473,-0.031268336,-0.013048519,0.03548966,0.025996262,0.04798324,0.02307636,0.01017053,-0.023147745,0.0065661725,-0.015987318,-0.007678941,-0.0877558,0.07252161,0.113885544,-0.03318894,-0.00020149465,0.072954744,0.012565956,0.044081457,-0.014742699,-0.066555925,0.036219515,0.039888166,-0.030308908,-0.040637076,0.03769779,0.007552239,0.02849696,0.007855114,-0.036525805,0.0013092111,-0.0044426536,-0.0044737547,-0.022929605,0.11599068,-0.09472527,-0.05797538,0.011185798,0.012264883,-1.00380495e-33,0.13485716,-0.08292914,0.05669429,0.05831077,-0.008102175,-0.016324218,0.01740398,0.006542639,0.020690078,-0.05051267,0.073664844,0.0050834073,0.078038625,-0.06706803,-0.05923066,-0.03500712,0.08034767,0.011980572,-0.013537063,-0.01758129,-0.044498622,0.06966708,0.009021681,0.08349296,0.066800445,0.06811892,0.090092435,-0.009432466,0.10407683,-0.028287197,-0.0028439658,0.022000626,-0.0671171,-0.05437374,-0.031747386,0.1147869,-0.018013472,0.0858664,-0.00012747232,0.0028408838,0.009434621,-0.02258219,-0.0744011,0.06724559,-0.051216215,0.06292523,-0.0030665558,0.010607354,-0.01676393,-0.08261554,0.033317838,-0.0048023188,0.025991466,0.0040179645,0.0442341,-0.043971486,-0.07758398,0.019761683,-0.035727706,0.0027828075,-0.017929658,-0.0065287347,-0.0027974073,-0.062378477,-0.049492158,0.03392559,-0.042830188,0.03725439,0.018442638,-0.017822396,0.033077747,-0.03370585,0.08598922,0.04974997,-0.023614757,-0.099916756,-0.02394317,-0.051044133,0.07844183,-0.052390765,-0.035422023,-0.043983813,0.05272052,-0.03958265,0.019731732,-0.009175397,0.07785493,0.054608185,-0.023356242,0.03366793,0.022457708,-0.006327469,-0.0018656297,0.01331325,0.058212426,-2.4807322e-08,0.08376025,-0.0501181,0.028953468,0.010538219,-0.027389692,0.08575022,-0.030656166,0.06414661,0.007586022,-0.013719713,0.0048609506,-0.0060444507,0.022074815,0.023958202,0.052042272,0.081441306,-0.028905785,0.018201793,0.024115158,-0.025929091,-0.10112477,-0.027643802,-0.1404398,-0.0058499924,0.023910007,0.006625229,-0.005432902,-0.012045939,0.013280555,-0.0599029,0.048623454,-0.09951332,0.04397461,-0.0069489176,-0.029161965,0.10431336,0.027144985,0.018473953,0.04059864,-0.025690734,-0.016237486,-0.08841979,-0.075554095,0.029016407,-0.053909,-0.07160402,-0.024977928,0.015883464,-0.029768527,-0.061177835,0.051782146,0.0047110184,0.027257614,-0.06602201,-0.0043163593,0.020153068,-0.01852893,-0.10780329,-0.050318476,0.054891337,0.028765665,0.05494303,0.082615614,0.017042654 +5.4.99.25,"Pseudouridine synthase TruB from Escherichia coli specifically modifies uridine55 in tRNA molecules [1]. The bifunctional archaeal enzyme also catalyses the pseudouridylation of uridine54 [6]. It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in Escherichia coli tRNAs by thymine.",384,0.99999994,-0.028107278,-0.06659296,-0.09808158,-0.064762704,0.0002014842,0.0011591278,-0.075153686,0.012911863,-0.001857689,0.035484422,0.005725296,0.03476554,-0.03208784,0.05183385,-0.06325949,-0.0044209557,-0.10669536,0.05501224,0.05303533,-0.049482927,0.08136611,0.05792471,-0.047153335,-0.021378767,0.006007753,0.012821234,0.069438115,-0.046766963,-0.040316924,-0.07501218,-0.10554102,-0.03516958,0.006453965,-0.08633928,0.046858788,0.03941071,-0.1338242,0.036431417,0.117575675,-0.002162268,0.03607499,-0.057833858,0.011121642,-0.04716226,-0.01929327,-0.012243276,0.006001515,0.08390384,-0.024368988,-0.00016077992,-0.095739156,0.03492004,0.01168813,0.05692386,-0.04390883,0.040489327,-0.08451392,-0.06612414,0.019111075,0.0021119402,0.048600726,-0.001793456,0.08459825,-0.07798504,0.07564104,-0.054005705,-0.02103908,-0.03153388,0.05959912,-0.06899954,-0.03597292,0.02485493,0.05654626,0.08176084,0.034132347,-0.04200643,-0.03148016,0.0076099476,0.011926,0.01737276,0.0008424032,-0.120212734,0.014510097,0.06445511,0.05265463,-0.011803508,0.005862907,0.060152482,0.033426482,0.0044885753,0.051174235,0.0033154418,-0.01592398,-0.055650882,-0.059793945,0.03278346,-0.03860703,0.065108456,0.006002447,-0.0705597,-0.0020070563,0.0018103564,-0.101422496,-0.05320331,0.013357379,-0.057663713,0.06276767,0.10174695,-0.01937945,-0.029175596,-0.012244541,0.008121752,0.07984389,-0.020362196,-0.014203713,0.035769083,0.0030669821,-0.06902462,-0.0407706,-0.039558064,-0.029329466,0.026773157,0.017440772,0.061867837,-0.037269372,0.04156505,-0.059149727,5.8666543e-33,0.062551446,0.07427449,0.005954487,-0.042936534,-0.009983923,0.013402399,-0.039456945,-0.0145081505,-0.015658492,-0.13668941,-0.101140365,-0.053824354,0.03866024,-0.062618464,-0.04740546,-0.009009066,-0.03302215,0.05152474,0.06396817,-0.057986286,0.07443805,0.12805565,-0.04548774,0.012005971,0.049274612,0.051561065,0.0024719741,-0.03435748,0.017078554,0.01489462,-0.0043512266,0.010077613,-0.09560724,-0.008534562,0.12746726,-0.05101242,-0.05775055,0.00036646458,-0.120494455,0.10857782,-0.0112620825,0.053654414,-0.038835377,0.04702792,0.02756968,-0.017844966,0.0058296616,0.081001595,-0.056749385,0.062289633,-0.03340195,0.0027164065,0.06781229,-0.029980432,-0.04310684,-0.070683934,-0.003499172,-0.06159743,0.07826051,0.0520229,-0.009273123,0.042803936,-0.01999221,0.047982518,-0.044397853,-0.014938559,0.0036797412,-0.053727727,0.051471114,0.10256612,-0.057516403,-0.0059930864,0.031201785,0.02862461,0.008712086,-0.035201248,-0.08433295,0.0056398693,0.019975234,-0.06952272,0.034981757,-0.06823439,0.0033651076,0.061965685,0.03431874,-0.006791099,-0.047847692,-0.042605445,0.0014344788,0.011280902,0.07331878,-0.06686507,-0.10524168,0.056041535,0.037754077,-5.5930943e-33,0.1307874,-0.10579855,0.08227293,0.016183903,-0.059986528,0.022528602,-0.012134057,-0.03769134,0.027177325,-0.038280845,0.07968226,0.015940586,0.032195136,-0.045884594,-0.017691402,-0.031922113,0.09106638,-0.006066653,-0.0043488573,-0.027031397,-0.014724582,0.0099386005,-0.05780172,0.07839808,0.035935566,0.06082385,0.014283356,0.04203282,0.06760361,0.018571625,0.0029453833,0.03201257,-0.017278844,-0.018938076,-0.011704362,0.08254158,-0.020386865,0.06484146,0.05642647,-0.046572734,0.041939873,-0.03996049,-0.039489716,0.059186593,-0.018281423,0.006036572,-0.030955307,-0.0142704155,-0.035302274,-0.09062075,0.048325464,-0.026657166,0.05686336,-0.05635629,0.05079136,0.0067779245,-0.059296973,0.032825544,-0.04530961,0.02857707,0.015944874,-0.040466607,0.04625402,-0.06333623,0.021705948,-0.010243795,-0.042678658,0.09980876,0.007997615,-0.03541136,-0.021227997,-0.017257405,0.028359523,0.049207684,-0.004636053,-0.05002521,0.024112532,-0.019172886,0.07269412,0.064724125,-0.041516177,0.0260509,0.03399646,-0.083107375,0.0186189,0.022082835,0.06704702,0.12565082,-0.01735851,0.05848234,0.009300298,-0.0069751497,-0.03179211,0.00019318823,0.01872466,-3.6629828e-08,0.03155982,-0.03472561,0.0446704,0.006746465,-0.017271105,0.05666385,-0.015122748,0.06527699,0.028669572,-0.02000427,-0.024068486,0.027592802,0.08515932,0.018816123,0.043966666,0.037441835,-0.07108894,-0.014282672,-0.013700983,-0.035578944,-0.04531199,-0.046230808,-0.14430186,0.018340131,0.06846136,-0.03256003,0.00573077,-0.06116869,-0.02709935,-0.03972395,-0.02971643,-0.08983213,0.047862977,0.026503064,-0.01548519,0.077983394,0.002804023,-0.07634529,-0.029473256,-0.042021383,0.021761676,-0.013928826,-0.08769818,0.019920148,0.0040451013,-0.00046304986,-0.0037083167,-0.0038623533,-0.061246406,-0.019689914,0.06463788,0.013696864,0.04744694,-0.017198816,-0.011187241,0.048623994,0.021972194,-0.116961405,-0.03761946,0.011496907,0.06821826,0.03141317,0.12929581,-0.0018697657 +5.4.99.26,TruC specifically modifies uridines at positions 65 in tRNA. ,384,1.0,0.023771176,-0.017366827,-0.08987389,-0.036918387,-0.11316812,-0.03136356,-0.045416307,0.056190956,-0.014665249,0.011004349,0.030859327,0.012030492,-0.04110669,0.04648815,-0.070054896,-0.010337637,-0.07523818,0.051261984,0.013626341,-0.06557261,0.008897924,0.07198607,0.016914997,0.027897358,-0.029441107,-0.032624934,-0.01697879,0.0042145704,0.01875237,-0.120290145,-0.091712035,0.030956956,-0.050088465,-0.05250513,-0.030322278,0.0017156799,-0.18245956,0.046540543,0.0715265,0.026764838,0.06998464,-0.07113332,0.020158507,-0.0024594523,-0.057210006,-0.0036807358,0.0033441777,0.07300417,-0.014032567,0.07209303,-0.024906656,0.03254243,0.02798138,0.14918484,-0.012940672,0.04919503,-0.12966055,-0.06508301,0.006456212,-0.034172077,0.004619817,0.033165593,0.0059031416,-0.104652554,-0.00690636,-0.05932292,-0.010082718,-0.015978798,0.020505376,-0.048330553,0.021163817,0.0068806447,-0.036609627,0.07964978,0.015398131,0.050603893,-0.021644222,-0.0043901447,-0.027930237,0.013429375,0.02000675,-0.06835815,0.019330543,0.038689498,0.08704697,-0.024713205,0.017397162,0.009926777,-0.07512644,0.06440992,0.12148156,0.030319875,-0.019424817,-0.016521962,-0.039848417,0.019609079,-0.020502713,0.046649683,-0.03928084,-0.061430532,-0.007926404,-0.010742057,-0.04868717,0.004891244,-0.041117985,-0.06368829,0.053068865,0.06349549,-0.0070267036,-0.021224502,0.0010786445,0.012189811,0.08985548,0.044966005,-0.015663179,0.01688542,-0.03661246,0.046993602,0.05021414,-0.026096515,-0.02473129,0.058791813,0.0057356367,-0.0120226685,-0.008895104,0.022537014,-0.004878943,-1.7864732e-34,0.07376552,0.017698979,-0.031488646,0.05706396,0.010260786,0.0052927597,-0.058414035,-0.03007078,0.015741158,-0.07316769,-0.16183996,-0.048859213,-0.019054499,-0.07816917,-0.023262555,-0.013285548,-0.047571927,0.035046685,0.0044052135,-0.069238015,0.048748273,0.13233614,-0.044618424,0.013222975,0.030557899,0.03990985,-0.021171238,0.008821832,-0.08209965,0.019042164,0.043039247,0.03700231,-0.035885062,0.0032053685,0.06873928,0.020073397,0.0016520746,-0.011922853,-0.12927534,0.08298148,-0.0060083373,0.0449921,0.03602967,0.010356009,-0.001618865,-0.023759013,0.007843331,0.013288973,-0.08464773,0.08174446,0.012911472,0.020262836,0.03452797,0.007909648,-0.011576606,-0.033420116,-0.029326307,-0.050260674,0.04947358,0.08697517,-0.006801767,0.08774911,-0.018406106,0.0614554,-0.06842738,0.0013232345,-0.059075695,-0.079176515,-0.014691697,0.084024705,-0.026041845,-0.033030376,0.058394313,-0.02944878,-0.0033254907,-0.03812276,-0.042450868,-0.016032724,0.0027364488,-0.06322431,0.007009883,-0.04783578,0.0077984123,0.07674187,0.065574504,-0.035438593,-0.0043137628,-0.036182385,-0.017079633,-0.015162374,0.054572947,0.009539715,-0.059188116,-0.013974164,0.084537774,-3.5526128e-34,0.08361334,-0.101616845,0.11362992,0.0672821,-0.0038270613,0.045288127,0.019799843,-0.043933928,0.01184594,-0.04094062,0.107531905,0.047793966,-0.0643025,-0.038527265,0.049233038,-0.07290605,0.027421242,-0.04667799,-0.024095936,-0.020805754,-0.030936165,0.0023979815,-0.055567693,0.0666985,0.028598513,-0.0022235594,0.029876966,-0.025561769,0.065365985,0.0071167964,-0.013374673,0.011603612,-0.01203557,0.03766116,-0.053537246,0.07161403,-0.035212725,0.07152108,0.052259713,-0.019337302,0.043919116,-0.074783154,-0.0026979805,0.057404146,0.005905972,-0.0031660583,0.02600817,-0.048249815,-0.062803954,-0.034222554,0.0860248,-0.0049187024,0.04672138,-0.034777682,0.072981246,-0.02430929,-0.059686407,-0.06085359,0.0028989962,0.01649376,0.051148824,0.04812829,-0.048519958,-0.07026291,0.0118917795,-0.0025186941,-0.023790242,0.044951312,-0.012242978,-0.005625054,-0.008149823,-0.07778862,0.040678415,0.020508602,0.019644184,-0.11745687,-0.03886682,0.00024645418,0.06458404,-0.02228376,-0.10296615,-0.004814449,-0.024539191,-0.06542871,0.07334841,0.023207836,0.024347886,0.07647332,0.002727154,0.10387134,0.011636696,0.00034335747,0.014746541,-0.020664698,0.023108156,-1.7344867e-08,-0.0018105251,0.009274323,-0.05155269,0.02428999,0.015423009,0.07676948,-0.0045439545,0.12288713,0.04246241,0.01642991,0.06286286,0.05415264,0.091584794,0.061849054,0.093300864,0.06633999,-0.0827137,-0.02683622,-0.010389602,-0.014016993,-0.10470907,0.016191985,-0.08583258,0.021356056,0.0031903936,-0.012859605,0.023270441,0.045313884,-0.053919885,-0.052657124,0.06901096,-0.08357442,0.041344546,0.015425326,-0.021686343,0.12620814,0.044221107,-0.05940115,-0.019032976,0.012940265,-0.038622595,-0.035313968,-0.050454516,0.025381321,-0.07328117,-0.04711918,0.0050911345,0.044584673,-0.111872405,-9.740247e-05,0.024486521,0.062687084,0.077092595,-0.013440011,0.01935361,0.08772392,0.04512781,-0.100783676,-0.028724777,0.023181712,0.0669955,-0.017601753,0.047122713,0.016355336 +5.4.99.27,"Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA [2,3]. The Pus7 protein from Saccharomyces cerevisiae is a multisite-multisubstrate pseudouridine synthase that is able to modify uridine13 in several yeast tRNAs, uridine35 in the pre-tRNATyr, uridine35 in U2 small nuclear RNA, and uridine50 in 5S rRNA [5].",384,1.0,-0.067655355,-0.08977605,-0.150376,-0.0558467,0.012437284,0.01789661,-0.08050333,-0.0026081474,-0.014372895,0.023136418,0.0272833,-0.022189206,-0.080728576,0.069726154,-0.10604116,-0.0223198,-0.118584104,0.0480288,0.11760913,-0.06660092,0.051670067,0.113500915,-0.013966267,0.013966727,0.0102084465,-0.006364348,0.06835925,-0.04385789,-0.012664259,-0.106604494,-0.097753346,-0.066039726,0.053227533,-0.025321772,0.070429005,0.039466742,-0.059709553,0.012961385,0.10323779,0.021169687,0.03248364,-0.037414946,-0.017947996,-0.047691494,-0.05203256,-0.010276506,0.01836568,0.04075931,0.021130612,0.016466226,-0.056643132,0.013198218,0.021765515,0.058949247,0.020363085,0.0064922483,-0.06866743,-0.056473337,-0.004729708,0.005137661,0.007423065,-0.034852438,0.06240119,-0.09245293,0.052707143,-0.050298195,-0.024113951,0.029534325,0.017346706,-0.05713389,-0.014530525,0.02063484,-0.01151459,0.07415087,0.02371917,0.04237311,-0.02162763,-0.011583837,-0.04163007,0.016318062,-0.0020040267,-0.09522632,0.031143084,0.030471362,0.065044545,-0.032608677,0.027026627,0.06042505,0.015322642,0.0020642108,0.093868814,0.03759326,0.032016568,-0.016933536,-0.043176595,0.074673496,-0.044907596,0.03540403,0.017724723,-0.08853042,0.007270183,0.047387175,-0.038352296,-0.05326623,0.071190596,-0.03210406,0.080111146,0.09489263,-0.012213909,-0.00950245,-0.017799238,0.030018322,0.053765688,-0.0038040094,-0.012639391,0.011706346,0.03319848,-0.045795687,-0.025226895,-0.031466402,-0.021355735,0.060102157,-0.018584052,0.083496064,-0.057417806,-0.04548344,-0.06435754,5.6822005e-33,0.06157092,0.096968204,-0.0024807411,-0.011667746,-0.04758393,0.025620613,-0.052273534,-0.010555557,0.01244059,-0.14042242,-0.06713456,-0.044146776,0.0028692964,-0.044162128,-0.06299515,-0.04875032,0.026464898,0.010542021,0.089179456,-0.08065542,0.06613953,0.11946366,-0.051984977,-0.019768119,0.0634105,0.04671466,0.04019007,-0.008752313,0.059464987,-0.03039595,-0.047313586,0.018797962,-0.068582185,0.022393199,0.10466299,-0.04215848,0.0064001526,-0.01218401,-0.06750949,0.10826158,-0.02134609,-0.005123462,-0.01906105,-0.021283861,0.048756436,-0.00836421,-0.02545911,0.0694526,-0.09328968,0.054957256,-0.011595301,-0.005276612,0.04605693,-0.008616872,-0.029073121,-0.03610492,0.0074501922,-0.07129919,0.07514745,0.006510357,0.004079463,0.002207512,-0.019172458,0.04142129,-0.047122493,-0.025303375,-0.026600767,-0.06653516,0.035617176,0.0898117,-0.08840337,-0.005010057,0.02730061,-0.00047820908,0.009218373,-0.035906322,-0.14976202,0.0028314698,-0.0036012118,0.010307587,-0.041029062,-0.05510031,-0.018012457,0.055312846,-0.020150779,-0.03435913,-0.022821242,-0.018144036,-0.034104858,-0.053937808,0.067565136,-0.021146871,-0.06134749,0.07120452,0.052415375,-5.1697955e-33,0.12788181,-0.08116517,0.11935116,0.011855846,-0.09121107,0.016994147,0.0009260752,-0.024407063,-0.0011973752,-0.024557006,0.0446483,-0.034218647,0.045055065,-0.09562112,-0.033599664,0.024706466,0.06371588,-0.012851007,-0.03212079,-0.034806274,0.006986352,0.029005773,-0.06139263,0.10141446,0.01553783,0.042219546,0.078254886,0.026810903,0.03642272,0.0012721174,2.9235394e-05,-0.015653778,-0.004124204,-0.008242795,-0.039580014,0.06571999,-0.014914423,0.047710523,0.018700218,-0.054986037,0.053493492,-0.034495432,-0.07136452,0.044867083,0.00056257186,0.040205855,0.038583558,-0.012168891,-0.028928772,-0.09784366,0.077013336,-0.019319668,0.06604333,-0.045448825,0.06626995,-0.059144843,-0.041044828,0.012566181,0.024524951,0.015721316,0.028630506,-0.029444288,0.001550749,-0.042477265,-0.0019947244,-0.028421916,-0.08480953,0.038538594,0.023487953,-0.029234556,0.011175014,-0.019735822,0.03756428,0.03561254,-0.001935746,-0.080185704,-0.025879895,-0.037485745,0.061091322,0.018077338,-0.06139963,-0.025694616,0.018630803,-0.035545234,0.034258015,0.044005204,0.08612567,0.07758424,-0.024044115,0.07744088,0.00023385446,0.05251082,-0.0006216063,0.027504362,-0.02549189,-3.6538562e-08,0.05777923,-0.04230288,0.046318077,-0.01520886,0.0037703617,0.04690849,-0.019451704,0.10154511,0.032845628,0.021005971,-0.037393745,-0.025074882,0.07556092,0.031309307,0.07254049,0.07356242,-0.062253434,-0.01533234,0.04316327,-0.024800418,-0.024757594,0.0026139535,-0.15056182,0.04585646,0.03445178,-0.0045423573,0.02415481,-0.01090913,-0.006760328,-0.07849908,0.027885744,-0.0704304,0.063749455,-0.0031890473,-0.029787565,0.101996504,0.07474672,-0.07535091,0.017236106,-0.006247683,-0.009983082,0.04472056,-0.07729006,-0.022912852,-0.074703254,-0.016525898,0.010666283,0.031863227,-0.017182697,-0.016931087,0.08057815,0.034304008,0.055964068,-0.041326717,0.011834537,0.04622481,-0.00032824298,-0.09441976,-0.034385514,0.059279583,0.0558216,-0.023579612,0.09440278,0.03586526 +5.4.99.28,The dual-specificity enzyme from Escherichia coli also catalyses the formation of pseudouridine746 in 23S rRNA [5]. cf. EC 5.4.99.29 (23S rRNA pseudouridine746 synthase). ,384,1.0,-0.0744915,-0.057044923,-0.099383794,0.004252046,0.051586162,0.076581836,-0.08904557,0.033272035,-0.06271498,0.026294982,-0.024437794,-0.049044255,-0.030465174,0.12429541,-0.00236317,-0.039242923,-0.1375637,0.037043884,0.029220887,-0.06353867,0.043446127,0.075605415,-0.024583463,0.028261777,0.033303585,0.0576976,0.09573606,-0.011991095,-0.02073741,-0.02952974,-0.04275643,-0.074555576,0.0578613,-0.033152934,0.071958914,-0.0005897532,-0.057803575,-0.00738063,0.11471175,0.03622825,0.013931307,0.063301064,0.0049538515,-0.046635717,0.0015454458,-0.019948488,0.017812435,0.025401229,0.023604251,-0.00023596254,-0.06629258,-0.03930857,-0.051906057,5.4286007e-05,0.07094209,0.033532776,-0.047151532,-0.10085228,-0.033056755,-0.003915424,0.058166597,-0.07113307,0.029859327,-0.06255381,0.03471975,-0.050459344,0.019184154,-0.018876534,0.040271185,-0.0590087,-0.029743027,0.004777623,0.043869074,0.082470775,0.07585989,-0.03151211,0.0003162478,-0.030048136,-0.044851243,-0.0037297923,-0.009102343,-0.11362645,-0.023778178,0.04224098,0.039943013,-0.005494328,0.049639553,0.052792676,0.08645383,-0.0021566218,0.038798206,-0.017994553,-0.0020066092,-0.06870442,-0.045875452,0.010062827,-0.056098912,0.054059304,0.05624449,-0.070558116,0.016239215,0.022475444,-0.06420228,-0.021810206,0.04207062,-0.033881232,0.014819609,0.094520755,-0.03520083,-0.027264785,0.08801942,0.044717036,0.06137827,-0.022811767,-0.060537364,0.059075393,-0.0045209043,-0.06645088,-0.045745693,0.012193728,-0.04259258,-0.026286298,0.058370665,0.10890408,-0.02305909,-0.021439867,-0.12818383,3.8383307e-33,0.01586575,0.033718463,0.026133321,-0.027524186,-0.021940362,0.026158726,-0.060987383,0.001611215,0.008084891,-0.05893431,-0.0200725,-0.028512087,0.08806123,-0.03695372,-0.06787478,0.00463061,0.002681046,-0.017279962,0.019433094,-0.007110356,0.048241712,0.12163649,-0.027790118,-0.0084681325,0.020000631,0.014123278,0.037809554,-0.049437188,0.11838007,-0.0044727493,-0.09365643,-0.059029166,-0.08796399,0.0743153,0.12400757,-0.009968609,-0.07147814,-0.026280235,-0.013602587,0.16686797,0.013982246,0.023711702,0.007111206,-0.02667148,0.033692144,-0.0225894,-0.025215758,0.12165627,-0.035676774,0.06217139,-0.009125122,-0.0027097948,0.0421877,-0.0061339024,-0.056277916,-0.027725555,-0.025039796,-0.009888498,0.06112774,0.009868323,0.01400583,-0.00844959,-0.03602642,-0.0020614425,-0.021042831,0.02139739,0.008964823,-0.077326745,0.06279119,0.110619664,-0.047615163,0.0039742454,0.07929604,-0.022147212,0.040187642,-0.04262722,-0.06254073,0.046831552,0.036773164,-0.012569684,-0.085577786,0.04500552,-0.028502528,0.051910207,-0.05669308,0.00027881112,-0.0005344897,-0.04515361,-0.019813934,0.070724435,0.0658956,-0.059955515,-0.052045442,0.025510838,-0.0017844137,-3.2877016e-33,0.07674894,-0.1157204,-0.008876898,-0.054822575,-0.08540336,-0.025564332,-0.03337477,-0.050191876,-0.00747529,-0.08822987,0.089587666,0.0018412485,0.05348443,-0.007453789,-0.06321535,0.011018868,0.057458017,0.077405915,-0.011221331,-0.0040906207,0.022156235,0.03359425,-0.019533549,0.09314487,0.13047938,0.030094707,-0.026878275,0.08411944,0.094905935,0.03852674,-0.031860437,0.012726164,-0.021256864,-0.037013646,-0.06854539,0.080953546,-0.0385728,0.041045748,0.061967574,0.012145396,-0.022867134,0.047089435,-0.0542423,0.07204724,-0.020456607,0.0490854,0.025317604,0.034873344,0.015608316,-0.09348987,-0.0018317938,-0.06119773,0.006542474,-0.057045523,0.01337446,-0.0070216414,-0.042276323,0.041891426,0.046583433,-9.02942e-05,0.062286805,-0.099583685,0.019120308,-0.035434477,0.021804178,0.041712105,-0.038705856,0.004745557,0.032017846,-0.046492424,0.03293289,0.0071263155,-0.0019161621,0.045257825,-0.029190563,-0.04996918,-0.028804502,-0.049413238,0.04540263,0.046773497,-0.029329522,0.00036306196,-0.008189516,-0.028831823,-0.004636461,0.002423259,0.06393668,0.09378708,-0.027097158,-0.012616082,0.0022195152,-0.020146688,-0.013006432,0.021011416,0.01201532,-3.4355136e-08,0.06910499,-0.10782808,0.019044088,-0.015702052,0.018214058,0.038839016,-0.045455217,-0.034556553,0.03029519,-0.024128146,-0.031075343,0.0070510223,0.025193384,0.009992675,0.025257323,0.04708264,-0.08681929,0.0028266006,-0.029855182,-0.027838308,-0.035751496,-0.027362853,-0.1277664,-0.013668308,-0.0013636606,0.009313481,0.025784725,0.002891181,0.00027301896,-0.09376348,-0.014260363,-0.09739212,0.05719609,-0.0020827763,-0.035827834,0.019717254,0.073340766,0.013042817,0.042306248,-0.028139621,0.019786289,-0.025119288,-0.10662183,0.05535978,-0.03105333,-0.008604443,-0.025355058,0.025343293,-0.0006177873,-0.0028717117,0.0988365,0.0055989395,0.100615285,-0.00246536,-0.01531658,0.012355859,-0.021485347,-0.05286573,-0.047767155,0.047176722,0.036540546,0.02722301,0.16328043,-0.002756176 +5.4.99.29,RluA is the sole protein responsible for the in vivo formation of 23S RNA pseudouridine746 [2]. The dual-specificity enzyme also catalyses the formation of uridine32 in tRNA [3]. cf. EC 5.4.99.28 (tRNA pseudouridine32 synthase). ,384,1.0,-0.03935222,-0.08614906,-0.13927631,-0.024804175,0.012518439,0.0646759,-0.066348225,0.048973337,-0.037870258,0.026708124,-0.009818742,0.0063010235,-0.053052273,0.06612255,-0.045378134,0.011204218,-0.13673264,0.0038190763,-0.027007988,-0.0995773,0.064684264,0.073519245,-0.004979565,0.0057446896,0.019623045,-0.0020736158,0.08440208,-0.07813839,-0.00022382948,-0.046308625,-0.05644328,-0.07485157,0.034537863,-0.05602664,0.047367737,0.016386792,-0.12358445,-0.028383853,0.10553514,0.055092875,0.026886996,-0.011927558,-0.0007606323,-0.06504312,-0.046121813,-0.04563445,-0.024877947,0.08442965,0.037100524,0.116208196,-0.010754432,-4.3965752e-05,-0.040659953,0.08220903,0.043545045,0.048212122,-0.070208356,-0.052714884,-0.037720352,-0.0029716194,0.0540207,-0.042754978,0.019512454,-0.096700355,0.059990704,-0.095393665,5.201749e-05,0.0070094895,0.09520512,-0.016259823,0.034566104,0.015407419,-0.040987104,0.09649451,0.058834296,-0.04076929,0.016727602,0.0030799508,-0.018594712,0.036147088,0.013031389,-0.04254518,0.043261867,0.038930625,0.10485935,0.01177839,-0.00271544,0.059227247,0.007081044,-0.012211551,0.03981988,-4.1852232e-05,-0.0036713576,-0.015302272,0.005954554,0.034431994,-0.032256547,-0.010218381,0.0061589424,-0.089117266,0.019799612,-0.025667004,-0.03652124,-0.0282156,-0.008980967,-0.026395783,0.025197785,0.07112916,-0.051270835,0.011518159,0.04840428,0.0046848585,0.06767824,-0.008049927,-0.016368652,0.05244748,-0.025735864,-0.03316174,-0.028114006,-0.01914122,-0.04459108,0.016961802,-1.3546471e-05,0.042336304,-0.01886944,-0.045585867,-0.10400539,2.3587009e-33,0.09089294,0.040216286,-0.07469715,0.019436877,-0.04095072,0.045402575,-0.05070492,0.04341495,-0.006539018,-0.06763778,-0.060418967,-0.04476738,0.031797286,-0.067470305,-0.110692,-0.011588273,-1.6098911e-05,0.0208925,0.021843746,-0.066525996,0.027819416,0.13095948,-0.009414008,-0.024897305,0.008313365,-0.01722277,0.035543494,-0.063616,0.060609266,-0.010637653,-0.058766577,-0.03565848,-0.07761896,0.010288194,0.10663866,-0.058267824,-0.042565465,-0.035152275,-0.052650593,0.1514288,0.02946177,0.025798908,-0.0035923447,-0.05214181,0.047253914,-0.01315867,-0.034523033,0.057487205,-0.061103657,0.08512671,0.026754698,0.016821442,0.02743859,0.01793049,-0.06599545,-0.08191693,-0.049388316,-0.04692537,0.06877157,0.037484773,-0.008822297,0.021039955,-0.0041335216,0.044287015,-0.029767074,0.0062409043,-0.027365832,-0.10709202,0.028896794,0.109196715,-0.04344626,-0.035230316,0.08056968,-0.02546874,0.021223154,-0.07378321,-0.05111041,0.054945365,0.028022,0.038055483,-0.031605054,0.013595689,-0.023844864,0.057925835,-0.090712085,-0.07312783,0.013393794,-0.090680555,-0.016768921,0.0061737928,0.07336447,-0.03353062,-0.08550665,0.054676823,0.03872544,-2.1217803e-33,0.088252805,-0.09847806,0.04875863,-0.036801476,-0.04567026,-0.03868211,0.019374127,-0.07465025,0.020111535,0.00053346565,0.0881879,0.016837986,0.0111899115,-0.010791903,0.029983293,-0.029148579,0.036123045,0.034130204,-0.0012797192,-0.025340501,0.0019900643,0.03452983,0.018728754,0.11001021,0.03356755,-0.026512317,-0.004488472,0.054190543,0.050373226,0.012561467,0.011849326,0.011012639,-0.024892073,0.021191949,-0.052078314,0.05879071,0.017730072,0.032625142,0.062249657,-0.025226709,0.054953247,-0.0036879801,-0.0624655,0.09565867,0.001237313,-0.027079018,0.0102162445,0.01578259,-0.046889678,-0.10143475,0.07152959,-0.07036767,0.043516383,-0.03758667,0.059622526,0.01323103,-0.078475334,0.01728327,0.040364698,0.04072451,0.01794788,-0.034042314,0.012339886,-0.03504447,0.0024515383,0.028919676,-0.013971026,0.06268193,0.023911957,0.03705629,0.06434403,-0.011093935,0.030796718,0.046274994,-0.021743434,-0.10597199,-0.03764359,-0.026510878,0.035353146,0.013855775,-0.06785247,0.0018579123,0.039364293,-0.042891715,0.06983414,0.033598255,0.037188884,0.12883444,-0.008223869,0.087650545,0.030140074,-0.022614667,-0.00949535,0.08351957,0.035247933,-3.6949725e-08,0.039216466,-0.02163237,0.007100261,0.012197448,-0.011570825,0.018213773,0.015115618,0.050125968,0.004519294,0.01643489,-0.0068966104,-0.033469643,0.011795888,-0.014219293,0.073772065,0.09611198,-0.1328598,0.018191513,-0.023337707,-0.014380874,0.013016713,0.016337277,-0.10206195,0.023347737,-0.054376505,0.016476447,0.06345092,0.014362363,-0.023126705,-0.07970294,0.034269802,-0.047687903,0.0770697,-0.0050596176,-0.09315282,0.029738698,0.14306109,0.025659526,-0.02903859,-0.005116643,-0.022913149,0.04799972,-0.06474404,-0.011874753,-0.040382367,-0.044998135,-0.040155213,0.02228156,0.007794683,-0.03147679,0.021204572,0.017805757,0.052926727,0.012792523,-0.0024386311,0.009526464,-0.091308236,-0.05093632,-0.017469168,0.039753687,0.0032458776,0.038347416,0.14702834,-0.010079602 +5.4.99.30,The reaction is reversible and at thermodynamic equilibrium the pyranose form is favored over the furanose form (90:10) [1]. ,384,0.99999994,-0.020128585,-0.0038051065,-0.048926864,0.02989825,-0.015483671,0.040468857,-0.0069423723,0.0005482412,-0.015009435,0.07789036,0.00445285,0.026705917,-0.1503218,0.029556025,0.004892228,0.040587805,-0.083645694,-0.05577668,0.038242124,0.07190659,0.061602328,-0.095570765,-0.02125809,0.06646483,-0.007504445,-0.004295128,0.056403324,0.12457072,0.027915334,-0.033019405,-0.05250652,-0.042627882,-0.032710236,0.0009953585,-0.08705047,-0.032637432,-0.050428703,-0.06959611,-0.03312237,-0.010519723,0.018120177,0.014734128,-0.01192054,0.0025251808,-0.021684691,-0.022937544,0.013186198,0.025107574,0.03899802,0.0029502893,-0.021595825,-0.015668247,-0.08196038,0.049008433,-0.013803392,0.06593505,-0.029008063,-0.024228428,0.013684916,-0.057657704,0.026416512,0.043888625,-0.1185153,0.036422152,0.006942425,-0.028186435,0.00044801718,-0.0066367495,0.007899768,-0.035406806,0.025182484,-0.08144595,-0.1389099,-0.10886173,0.07180439,0.041993316,0.0038957428,-0.0044629686,-0.07815039,0.08059686,0.049614042,0.0186616,0.0046677664,-0.04213171,-0.05119159,-0.0037269292,-0.0052097086,0.03455018,0.08970257,-0.059844486,-0.00408945,0.032452933,-0.026497502,-0.04485648,0.014889194,0.07102509,0.097565696,0.070786886,0.080609135,-0.013335082,-0.033203147,-0.074754186,-0.038462378,0.0023360706,-0.077787705,0.078721255,0.04692082,0.040057927,0.011823446,0.010735388,-0.07646954,0.00596382,0.016718598,0.06637877,-0.033993572,0.03276349,-0.01914725,-0.045326002,-0.086781785,-0.022003371,0.09139405,0.049397215,0.014026949,0.026392527,-0.08034749,-0.014471146,-0.033598986,1.1383112e-34,0.036348604,0.018079557,0.045160826,-0.07887854,0.08314794,-0.01756894,-0.05898237,-0.032183375,-0.023140166,-0.01221657,-0.065486565,-0.03611746,-0.014003054,0.002748863,-0.13519455,-0.004998432,0.036280703,0.077034555,0.012490955,0.033210073,0.017000237,0.14058235,-0.032022722,-0.06674951,-0.043390658,0.06987036,-0.045578204,0.08068902,-0.011797183,-0.008928157,0.0996327,-0.0627374,-0.11715038,-0.033559818,0.061446693,-0.0027367226,-0.101082854,-0.023311263,0.024534121,0.027681218,0.025344167,-0.032979198,-0.048596192,0.056331277,0.019831738,-0.05924551,0.010339189,0.022106599,0.014519076,-0.014082318,0.00092438975,0.025976693,-0.04596604,0.05018959,0.014385544,-0.012768976,0.0211343,-0.039891843,-0.005643699,-0.024993187,0.080678485,-0.0013857224,0.03149257,-0.07195091,-0.025606243,0.062382046,-0.03025053,0.01779631,0.03073919,-0.033551604,-0.042485315,0.06255449,0.0007470623,0.0032056188,0.07672178,-0.0064602997,0.0031096435,-0.019240705,0.03514824,0.011473517,-0.13410224,-0.024566028,-0.0479093,0.04946735,-0.048180036,-0.0738057,-0.037972566,0.0038983282,0.018957008,0.10053201,-0.041520715,-0.022107476,-0.0005731709,0.029353837,0.043372788,-2.5338543e-33,0.05173706,-0.07826203,-0.06228647,-0.024961224,-0.047226325,0.050128944,0.045463424,-0.015256346,-0.03363679,-0.019269599,0.056409497,-0.031136382,-0.07493775,-0.049929775,0.02346406,0.06376407,0.030478006,0.077357784,0.008860683,-0.02647297,-0.05482091,0.077746876,-0.0074201063,0.049132917,-0.020003367,-0.07037281,0.061321296,0.0136070885,0.12938051,0.062950134,0.039438087,-0.054227106,-0.024021586,0.015059021,-0.009383899,0.059926216,-0.022552267,0.051340546,0.038656183,0.050883707,0.10011951,0.017337583,0.04185872,0.07450547,0.064565815,0.078517504,-0.06428237,-0.017790068,0.003131135,-0.029906757,0.11500391,0.025284575,0.030099977,0.037291717,0.06236942,0.0675928,0.031570245,0.001790582,0.053604234,-0.049183436,-0.0627091,-0.07746452,-0.00960228,-0.07280936,0.06510586,0.023931604,-0.11372539,0.05320794,0.060872886,-0.016345112,0.13965878,0.01038685,-0.024953391,0.013739135,0.027155092,-0.012300533,-0.012247962,-0.031641647,0.024669698,-0.018252494,0.018596502,0.050924405,0.029077187,-0.07813041,-0.05583691,-0.103832014,0.044169806,0.022975048,-0.04936073,0.007952761,0.032089803,-0.042529464,0.047903687,0.06312301,0.12194696,-3.0477022e-08,0.01415145,-0.013404994,0.06742586,0.024725625,-0.050440095,0.05125086,0.023504512,-0.00088403455,-0.008828987,0.010129391,0.011206625,0.073267646,0.07608296,0.0013193155,0.010032256,0.04088099,-0.04648209,0.015325993,-0.0112505825,-0.01324238,-0.035720095,-0.00015039739,-0.14202662,-0.05891434,-0.028334381,-0.030241853,-0.03848372,0.040394034,-0.095971845,0.007937358,0.04968201,-0.011964028,-0.049320452,0.020982532,-0.026218489,-0.0115005765,-0.01971934,-0.021167377,0.05289758,-0.06441991,-0.00402336,-0.024957055,0.027964506,0.009801314,-0.047261104,0.017050387,-0.010731968,0.0053021214,-0.05128732,0.05402136,0.10543269,-0.025866147,-0.012635869,-0.08553708,-0.08666532,-0.037940167,-0.005637627,0.035319135,-0.052946504,-0.07136397,0.034547046,0.017443495,0.092678554,-0.0061340383 +5.5.1.17,"The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene (cf. EC 4.2.3.55, (S)-beta-bisabolene synthase). The second step is the isomerization to (S)-beta-macrocarpene.",384,1.0,-0.0044694277,-0.0037613746,-0.013200107,0.054370124,0.0012202855,0.042282213,-0.046991713,0.02307959,0.067694016,0.012416693,-0.013820396,0.01276442,0.007185365,-0.0850457,-0.04403825,-0.020374177,-0.0465436,0.06850998,0.020302897,0.055015016,0.0064051417,-0.033832073,0.049605634,0.011495038,0.0803891,0.037555378,0.065231375,-0.04869472,0.0030042278,-0.046044793,0.0017017446,-0.00055529317,0.03573452,-0.0960344,-0.00378561,0.003235513,-0.010570622,-0.0038762742,0.050190125,0.010455144,0.055695247,-0.027345505,0.034027416,-0.045849588,0.034683373,0.025946165,-0.008330414,0.026007183,0.018659355,-0.065645605,-0.0056236703,-0.14761768,-0.081207566,-0.009013705,-0.0056987903,0.0050644497,-0.060478237,0.018462691,0.06190346,0.1092817,0.07406771,0.023954447,-0.002748353,-0.00057606946,0.0019511937,-0.05432235,-0.026441634,-0.06263921,0.038074337,-0.03172411,-0.14024533,-0.03800377,-0.07282562,-0.00030047516,-0.022916678,-0.013554768,-0.023466615,0.0821178,0.019551385,-0.08001463,0.07541156,-0.10818887,0.008345529,-0.017900836,0.0327509,0.0580114,0.008642554,0.036176763,0.04449754,0.02692409,0.060171194,0.060098227,-0.045041118,-0.04511684,-0.049423546,-0.0062143565,0.014913041,0.09068364,0.0442253,0.019543085,0.058877636,0.049457636,-0.017831033,-0.09638919,0.018775605,0.021414794,-0.050740577,-0.018075818,-0.020831615,-0.078883424,-0.032563884,-0.019834602,0.0754068,-0.0148739675,-0.04156345,0.05180171,-0.024581097,-0.045814052,0.02685817,0.023978466,-0.0066446164,0.0075002834,-0.010513104,0.08435592,-0.035001293,0.0037182483,-0.026261488,1.8223297e-34,0.013763607,0.15186788,0.05671941,0.06157196,-0.08760838,-0.016904637,-0.01414039,-0.01858719,-0.067414306,-0.0069146403,0.011588942,-0.037982784,0.003021456,0.049591348,0.050351586,-0.0039188494,0.036789324,0.035048477,0.10631486,-0.12692319,-0.042862672,-0.0024791854,-0.03929419,-0.020046137,0.065919526,0.023418425,0.012264442,0.01700382,0.06852069,-0.030671425,-0.021344302,-0.03698174,-0.03000023,-0.014292767,0.014686074,-0.06761769,0.0056996387,-0.060697038,-0.07371786,-0.012350884,0.044184335,-0.05015424,-0.07237251,-0.0069014602,0.0497038,0.035446946,-0.02568931,0.0043692277,0.107380055,0.016736345,0.01882975,-0.016844051,0.04060341,0.06095981,-0.097864464,0.024363104,-0.04326652,-0.032272317,0.028501058,0.0388885,0.00013944901,0.052135173,-0.055450916,-0.009265547,-0.020897109,0.067987345,-0.09677942,-0.0037820525,-0.06995215,0.050325457,-0.004012725,-0.026616052,0.100550435,0.0016264056,0.020621302,0.048374735,-0.08312672,-0.029719014,0.047571585,-0.062408313,-0.010104279,0.04445871,-0.06352095,-0.023610156,-0.011983278,-0.023246188,-0.011189922,-0.033078197,-0.0062285303,0.13582437,0.017443078,-0.087056234,-0.07058174,0.08019358,0.0014252355,-1.2920347e-33,0.057245065,-0.0117562385,-0.04653654,-0.062965766,-0.012827119,-0.005028703,0.0035089713,-0.11974497,-0.0081727775,-0.057567306,-0.014735607,-0.044337533,0.09489414,-0.058694445,-0.046764128,-0.06769045,0.06994825,0.024275266,0.002999248,-0.02293627,0.0360704,-0.0107318405,0.07774976,0.098318525,-0.04612927,0.0027391517,0.07008807,0.07139669,0.09979687,0.13970158,0.02415884,-0.028098326,0.018274438,0.00306343,-0.12011233,0.08098628,-0.030214416,0.06370703,0.069751054,0.037405387,-0.047217026,-0.058454238,-0.10166802,0.0062148347,0.15834415,0.04805016,0.0066117826,0.017281717,-0.008324227,-0.07955139,0.080932654,0.022253511,-0.012219179,-0.0053661405,0.008099426,0.0034236962,-0.05373487,-0.049584348,0.05193711,-0.09802088,-0.020442378,-0.058657352,0.026141671,-0.11542589,0.03481084,0.07441798,-0.026338756,0.079720765,0.013261568,0.0005103606,0.044459663,0.024938086,-0.009622017,0.045666907,0.027263401,0.039440304,0.069116384,-0.0922106,-0.019244635,-0.038077492,-0.09617226,0.01320643,0.015747502,-0.044720773,-0.06456366,-0.0519353,0.022115497,0.033414196,0.05906678,-0.005792892,-0.03189511,0.036423337,0.018243924,0.08205392,0.045195613,-3.441706e-08,0.096974924,-0.03314338,0.049740233,0.011294646,-0.008839945,0.027109357,0.05805583,0.010390804,-0.038352076,-0.044095553,-0.09332307,0.035576142,0.050304335,0.052513327,0.072467916,0.021430677,-0.06686274,0.011206681,0.003472074,-0.05362671,0.0278393,0.004671741,0.0074776607,-0.014329721,0.008964582,-0.12564427,0.018630842,0.004145082,-0.05506687,0.015215846,0.09508762,0.015298159,-0.0401544,0.059805244,-0.012458728,0.0020448894,-0.017258069,0.017772257,0.012733721,0.04389647,-0.029779404,-0.011061314,-0.10181368,0.04885715,-0.059844885,-0.00071289745,0.02266913,0.005156092,0.0026950336,-0.02198409,0.037006844,-0.013838702,-0.07119807,-0.079787716,-0.025769189,0.0028766042,-0.035018835,0.021073546,-0.024132594,-0.06282808,-0.031778835,-0.034029268,0.1078908,-0.0022751244 +1.7.2.4,"The reaction is observed only in the direction of nitrous oxide reduction. Contains the mixed-valent dinuclear CuA species at the electron entry site of the enzyme, and the tetranuclear Cu-Z centre in the active site. +In Paracoccus pantotrophus, the electron donor is cytochrome c552.",384,1.0,-0.08050282,0.021113766,-0.10879808,-0.0110179745,0.072827905,-0.0016120574,-0.05335707,0.02392258,0.017093783,-0.010635999,0.005637413,-0.08471081,-0.012180424,0.009101584,-0.080334105,-0.017685028,-0.016177831,-0.051421132,0.022083636,-0.020998945,-0.014535299,0.016485965,-0.0075612683,-0.059888948,-0.021841155,0.040879235,0.0003835767,-0.05956303,-0.023528464,-0.05531535,-0.032582704,0.03568536,-0.01923089,-0.052619018,0.080855355,-0.04617926,-0.039556865,0.025808984,0.066692,-0.0025395015,0.067386724,0.029139796,0.024523912,-0.030620782,0.0042763664,0.030439097,0.032253053,0.053807367,0.055814933,-0.05281849,0.011125431,-0.02480566,-0.029333478,0.06233708,0.016429536,0.046594884,-0.04877683,-0.11850426,0.045598343,-0.00046427158,0.081949756,0.0016924002,-0.06218535,0.04032235,0.04899713,-0.08454592,0.08466119,-0.031982508,0.015350576,-0.04753027,-0.024046868,-0.038193148,0.084666215,-0.034948442,0.005793858,0.0709895,0.102659985,-0.032395594,0.061344896,-0.021913607,-0.0120205255,0.0042116493,-0.045863654,0.092100106,0.04675208,0.005733408,-0.031150911,-0.04060081,0.002403533,0.02144906,0.035644453,0.002614633,0.02013986,-0.08771296,-0.14421111,0.0075704046,-0.0024134535,0.06145723,0.036092564,0.010906634,0.046615716,0.04794435,-0.0005258039,-0.12519887,-0.09234886,0.04953096,0.036563076,0.08136915,0.07765413,0.09453395,-0.00064027106,0.044065934,-0.014340442,-0.045632735,-0.020744886,0.04022188,0.018027484,-0.07953499,-0.0777176,-0.04355335,-0.009636859,-0.07971558,-0.03390733,-0.0131992055,-0.024488267,0.033584908,-0.023434797,2.5825097e-33,0.037743937,0.01792219,0.011719588,-0.069976546,0.060391914,0.013337962,-0.063420504,-0.0022035455,-0.021648528,-0.0025355835,-0.09845954,-0.07079925,0.019853372,-0.010386807,-0.09181683,0.029003298,-0.0086246645,0.015262105,-0.038377047,-0.028092647,0.0071728933,0.098115616,-0.04443063,0.022943234,0.078586884,0.03342055,-0.09157965,-0.06598849,-0.008047386,-0.010695452,0.07090877,-0.035513364,-0.06949411,0.018077014,0.11302899,-0.013286362,0.029794302,0.0018129705,0.0075541227,0.0917188,-0.024772836,0.05413809,-0.03620394,0.04694651,0.0049860743,-0.085467346,-0.04520116,0.06255254,0.07489704,0.034103803,0.015454163,-0.114217944,0.04715035,-0.049677663,-0.007825866,0.06082327,0.011500065,0.0041623884,0.13123284,-0.019410232,0.03868332,0.08287523,-0.06678839,-0.03478116,0.03982565,0.02414402,-0.04749401,-0.033081546,0.024858853,0.028106429,-0.11999532,0.050012525,0.0011913358,0.023894722,0.06920717,-0.076553896,-0.07080528,-0.017918931,0.09178364,-0.024009177,0.069857426,-0.009069962,0.060704198,-0.03868688,-0.03766718,-0.021497892,-0.07435716,0.021466248,0.009981076,0.007124538,0.04497849,-0.031505607,-0.051856425,-0.06522684,0.008276928,-3.3702797e-33,0.037673417,-0.07573526,0.004630108,-0.058044586,-0.067511424,0.04033035,-0.0398072,-0.042933654,0.034846,-0.0067606685,0.14093715,-0.0072253603,0.0785026,0.0017876722,-0.0040749433,-0.04208293,-0.027655827,0.11894348,-0.022451852,-0.063430265,-0.073757395,-0.02882341,0.021790665,-0.0855063,-0.031248823,0.016905902,-0.026245391,0.039121576,0.11849549,0.03255489,-0.0146661755,0.042168707,-0.078368746,-0.005073234,0.009394202,0.022285353,-0.04538753,0.050883994,0.016456272,0.03132812,0.012242853,0.03414914,0.041488055,0.10795358,0.00796462,0.023583096,-0.09816118,0.00010875809,0.031604562,0.021792898,0.090325125,0.03749926,-0.016397651,0.013334012,0.07205521,0.07464401,0.03293604,-0.071879424,0.04348487,-0.06075667,-0.057333957,-0.065346554,0.00011746029,-0.010811414,0.07009331,0.046998538,-0.02782843,0.2154994,0.025311522,-0.063191995,-0.003281528,0.04778215,0.0077675167,-0.060436375,-0.05787747,-0.041762736,0.0020169637,-0.018050032,0.06254344,0.009286924,0.008248025,0.0029219761,0.041503172,-0.10957115,-0.026819952,0.031213127,-0.018958794,0.055669382,-0.001763253,-0.021141274,-0.045530986,0.020977154,0.04536366,0.039626334,0.028401453,-3.767745e-08,0.023415996,-0.028409889,0.046425607,0.029561369,0.016673991,0.03438246,-0.02939971,-0.036208473,0.056335878,-0.0038291183,0.022855558,0.10778985,-0.011283457,-0.06441825,0.064066,0.05197714,-0.045093756,-0.07726725,-0.01226766,0.054667518,0.0013034515,-0.01917531,-0.0872244,0.038191102,0.046579763,-0.04720011,0.06964222,0.032561995,-0.057226446,-0.053285535,-0.06718309,0.02961923,-0.051508427,-0.025986945,0.006251461,-0.03448462,-0.02015685,-0.01038369,0.0019566445,-0.011623596,-0.012972139,-0.008360188,-0.08532269,0.010705376,-0.048883207,0.011729762,0.066420235,0.00089743786,-0.07044031,-0.017566275,-0.049187213,-0.023706166,0.03313951,-0.0325248,-0.08788251,0.00033804338,0.028611911,-0.019151263,-0.01979442,-0.02581949,0.03118345,-0.003727436,0.04779354,0.0711382 +1.8.5.3,"The enzyme participates in bacterial electron transfer pathways in which dimethylsulfoxide (DMSO) is the terminal electron acceptor. It is composed of three subunits - DmsA contains a bis(guanylyl molybdopterin) cofactor and a [4Fe-4S] cluster, DmsB is an iron-sulfur protein, and DmsC is a transmembrane protein that anchors the enzyme and accepts electrons from the quinol pool. The electrons are passed through DmsB to DmsA and on to DMSO. The enzyme can also reduce pyridine-N-oxide and trimethylamine N-oxide to the corresponding amines with lower activity.",384,1.0,-0.019984346,-0.065878645,-0.09978484,-0.013776232,0.05470727,-0.02904081,-0.026904019,0.05534784,0.007554814,0.00047299065,-0.014105227,-0.0032905368,-0.02939555,0.06186303,-0.024645096,0.08775797,-0.041770574,-0.005124464,0.025188487,-0.017702455,0.02269457,-0.012135312,-0.041631784,-0.078479245,-0.027331773,0.064086825,0.08451492,0.0507366,-0.04961518,-0.0683922,0.016021298,0.026249541,0.014147408,-0.03512454,-0.006579762,0.102420785,0.0038374264,-0.021713873,0.021828465,-0.07419163,0.050303463,0.084805876,0.027684292,-0.024284836,-0.038222346,0.052795615,0.026261834,0.06292161,-0.028844152,-0.054974213,0.0045584175,-0.042970728,-0.051378537,0.11909209,0.0033301846,0.05582997,0.01066343,0.005434212,-0.023507409,-0.028748488,-0.019088812,-0.020530514,0.026262265,0.024789304,0.05394639,-0.041941974,0.07431862,-0.008090073,0.007168549,-0.08877801,-0.059427243,-0.050158426,0.010829453,-0.03406664,-0.037022065,-0.046088897,0.012295577,-0.04343947,0.12697467,-0.02999968,-0.015541267,-0.0078004887,0.04129251,0.10704461,0.052344732,0.040875897,-0.018810416,-0.08058485,0.005456002,-0.0035522685,0.020013029,-0.068725385,-0.051758386,-0.034073334,-0.1013738,-0.008260505,0.008627602,0.09981174,0.0006103684,-0.0011680156,0.018438114,0.05375875,-0.08054538,-0.073813945,-0.075668566,0.02134016,0.0867132,0.13394138,0.037007567,0.04552438,0.0032796864,0.0432504,0.08966753,0.076966204,-0.03572519,-0.017506225,0.10122769,-0.11072317,-0.045500927,-0.025973566,-0.019085964,-0.00085537997,0.063014016,0.016776258,0.0006064828,0.034167975,-0.07780934,2.420157e-33,0.05700533,0.023657333,0.01967257,-0.050452255,0.03733017,-0.00067377504,-0.027713906,0.035367433,-0.037189882,-0.02907467,-0.13889083,-0.09798495,0.074651025,0.018252349,-0.06831741,-0.038872194,-0.042241585,0.033037946,0.058867138,0.014393989,0.048690777,0.03390423,-0.016862411,0.0034382655,0.08503513,0.07937742,-0.01850334,0.07165112,0.044423256,-0.014024351,0.0049246675,-0.07231487,-0.054770187,-0.0059209634,0.061478663,0.03570036,-0.078361675,0.011797629,-0.0053087063,-0.018098727,-0.040753447,-0.00255746,-0.022769183,-0.013381298,-0.0469677,-0.03670308,-0.04474324,0.021601945,0.024168793,0.045801707,0.041026883,-0.08819284,0.052482273,-0.105291,-0.06467377,0.022061232,-0.026160065,-0.047343355,0.034766674,0.033846673,-0.025749626,0.060076073,-0.08100557,0.004136581,0.10105451,0.01351894,-0.020692065,-0.045939498,0.038923707,0.023046989,-0.070241384,-0.011621398,0.064636566,0.057150703,-0.06264141,-0.026214821,-0.02006894,-0.05960545,0.080121525,-0.015770407,0.061672363,-0.06792857,0.018874837,-0.096435994,-0.00177392,-0.041272093,-0.019664967,-0.12619993,-0.04079383,0.00039735256,0.030922985,-0.08388075,-0.046958335,0.038865697,-0.006580166,-4.2813903e-33,0.066433676,-0.03272264,0.052058678,-0.023573548,-0.038309373,0.06466055,0.008199573,0.05390914,0.069281064,-0.04152986,0.064253524,0.023752332,0.019380054,-0.014047289,0.020812443,0.037748083,-0.027520606,-0.0062466566,0.018826418,-0.069131516,0.04731847,0.086362414,0.013393782,0.06312324,-0.029350672,0.020313222,-0.023930397,0.0027065154,0.10094447,0.060520913,0.017869495,-0.021813706,-0.036257602,-0.024281386,-0.018858334,0.032175343,-0.08788705,0.07731118,0.013510082,-0.030297048,0.00424476,-0.022033108,0.022625951,0.09293525,-0.009536514,0.04065394,-0.09989958,0.032760598,-0.0006064992,-0.009915379,0.00014279436,-0.0069751623,0.0013868468,0.04763051,0.06947361,0.06029897,0.03888901,0.017164864,-0.015741302,-0.0014077808,-0.06919536,-0.12093455,0.019494582,-0.038357735,0.002689323,0.07241615,-0.06671111,0.06147262,0.011953457,-0.028712867,0.038804088,0.05212112,-0.03042832,-0.03599298,-0.09059729,-0.101009026,-0.10149849,-0.010187906,-0.011865913,0.043148734,-0.010702189,0.021019123,-0.0051470497,-0.033277616,0.012368817,-0.088933945,0.056133986,0.101449996,-0.015778713,-0.010273638,-0.037705094,-0.00067905884,0.025555603,-0.040656228,0.006382098,-4.30337e-08,-0.03897649,-0.06224058,0.037189774,-0.014459475,-0.0462213,0.016024366,-0.004556695,0.034908053,0.048090093,0.012616007,0.10234245,0.15202262,-0.094604395,-0.0034250529,0.056909874,0.025467051,-0.053927362,-0.0059169466,-0.01704635,-0.038314402,-0.02141603,-0.043935508,-0.11235864,0.034615234,0.11128732,-0.05979202,0.044303354,0.052067142,-0.06658769,0.004704379,-0.043479994,0.0221348,-0.04076633,0.01632866,-0.037088696,0.00021255268,0.0027443406,-0.026709963,-0.028390978,-0.0027730004,0.04419627,-0.028441695,-0.06321571,0.060080215,-0.020391272,0.045615762,-0.01183339,0.029831037,-0.04760952,0.015451235,0.062658854,-0.0197768,0.035771765,-0.06053154,-0.14495681,0.0603389,-0.034438033,-0.055120107,0.015757514,0.001774411,0.055357378,-0.017430158,0.10569608,-0.013840792 +1.14.13.122,"Chlorophyll b is required for the assembly of stable light-harvesting complexes (LHCs) in the chloroplast of green algae, cyanobacteria and plants [2,3]. Contains a mononuclear iron centre [3]. The enzyme catalyses two successive hydroxylations at the 7-methyl group of chlorophyllide a. The second step yields the aldehyde hydrate, which loses H2O spontaneously to form chlorophyllide b [2]. Chlorophyll a and protochlorophyllide a are not substrates [2].",384,1.0,-0.10205551,0.030867234,-0.072664164,0.039912578,0.0660542,0.044605758,0.012583325,-0.042084716,0.018898945,-0.0121759875,0.014331447,-0.11357442,-0.015817111,0.022931922,0.020023499,0.124918,-0.105646625,0.011949012,-0.07771009,0.025334187,0.0273501,-0.029413413,-0.06689405,0.013654569,-0.048590347,0.006970791,-0.0630194,0.010852972,0.0146988155,-0.08206543,-0.0515057,0.04387929,0.00695369,-0.044862017,0.09905068,0.06002545,-0.0011420989,-0.15017872,0.014512741,-0.004333679,-0.030035766,-0.009470641,0.0025721397,0.004885655,-0.09296743,0.016484875,0.08564176,0.016000357,-0.050383072,-0.06281134,0.017253183,-0.025673602,-0.030458836,0.008649007,-0.013968098,0.07774428,-0.027055418,0.009080854,0.049163084,-0.036155824,0.05758233,-0.019345727,-0.03596061,0.007621388,-0.022730054,-0.00788731,-0.04988452,-0.06318028,0.021358466,-0.04765709,-0.08081634,-0.0769801,-0.03421562,0.04552094,0.04347946,-0.003255625,0.07740043,-0.056917347,-0.046400372,0.0313577,-0.0022598205,0.03451725,-0.019857945,0.08884508,0.036131736,-0.02155115,-0.006740463,0.022060202,0.0031556154,-0.009465074,-0.036282104,0.019085405,-0.015668888,-0.030539721,-0.086162575,0.14451264,0.037272844,-0.079727195,0.04308096,-0.04634248,0.0023935002,0.024437163,-0.010954473,-0.05756338,0.026303388,-0.019061973,-0.05006831,0.105982974,0.015457217,-0.03100216,0.034233354,0.020948034,0.025954736,0.0045451783,-0.021897752,0.09755775,0.041292258,-0.023672417,-0.033087224,0.008583826,0.014259329,-0.019380167,0.014154985,0.012820951,-0.03657473,0.026574694,-0.07997082,4.9595616e-33,0.06296021,-0.052855123,-0.035491392,-0.011227993,0.020125609,-0.10626218,-0.01617964,-0.039464474,-0.060667798,-0.077605784,-0.02753009,-0.059539862,-0.002540306,-0.024817826,-0.049940646,-0.00588811,0.021431971,0.017520573,-0.06173866,0.06856451,0.023120584,0.079407886,-0.016427036,0.03176274,0.025134495,0.08675582,0.04457325,-0.03046688,0.117361605,-0.017884025,0.045806784,-0.0009877897,-0.046286948,0.026776394,0.07542191,0.052664846,-0.054249126,-0.0114710815,-0.009072965,0.061226774,-0.047229923,0.08880161,-0.023850024,0.0075377836,0.08586217,-0.033911902,-0.053235922,0.023613848,0.016990868,0.048447818,-0.019614412,-0.022054357,-0.018605249,0.008333709,-0.06576381,0.02524192,0.034191247,0.002600438,-0.01593672,0.040875223,-0.030546274,0.048348088,-0.024852527,0.03278042,0.04113977,0.0062948363,-0.012601607,0.031589933,-0.014404424,0.010094742,-0.051864848,-0.05199315,0.0641485,-0.012768495,0.14413764,-0.047401495,0.0032845514,-0.05835332,0.0072185625,0.064710304,0.056871094,0.009237989,0.1419448,-0.12365933,-0.111173876,-0.069596015,-0.01822835,-0.02743696,0.013277256,-0.019683171,0.011857718,0.01704632,0.049011033,-0.07055308,-0.08634533,-6.0975015e-33,0.08606894,-0.11892191,0.04521724,-0.05364507,-0.04570419,0.007911359,-0.08521754,-0.15994988,-0.048522443,0.07848945,0.11561059,0.05656852,-0.106541574,0.026590114,0.020228898,-0.05802909,0.098798275,0.10173363,-0.022736065,0.027322695,-0.029337224,0.026608994,0.048279084,0.01770684,0.03298785,-0.048204497,-0.010500332,0.001262078,0.08973632,-0.006859332,-0.072961055,-0.022621732,-0.017653564,0.0076042223,0.0533325,-0.011908558,-0.088601865,-0.028329523,0.017069295,0.09695949,0.03018113,-0.08124628,-0.029324856,0.0006455255,0.016293963,-0.021402115,-0.11522827,0.02755809,0.0077448483,-0.007627285,0.010684671,0.014447082,-0.047809605,-0.017347638,0.009775317,0.065341726,0.092070565,0.027941408,0.032127194,-0.011805506,0.002125949,-0.063250534,0.03777436,0.014554335,0.023470942,0.12525745,0.022757353,0.098026544,0.00036231233,0.016480543,0.042907875,0.054618075,0.08311596,-0.010314319,-0.02871238,-0.050688628,-0.008368645,-0.023375759,-0.05836108,-0.038496576,-0.001389999,0.009270217,0.06126068,-0.050022278,0.020344358,-0.11950532,-0.009730035,0.023981959,-0.06617827,-0.02254339,0.014163739,-0.01838241,0.07975745,0.090773836,0.08039021,-4.4352063e-08,-0.032200016,-0.012970576,-0.06639316,-0.027473997,-0.013599858,0.037530474,-0.051656548,-0.032928757,0.05763135,0.028494,-0.024468996,0.028514612,0.07351441,0.010205968,0.009036556,0.025063865,0.016482612,-0.06989677,0.030269615,0.03569206,-0.08943033,-0.04516913,-0.09808906,0.014824181,-0.019569673,0.0041123745,0.04555716,0.038749818,0.045186177,-0.025076399,0.04825748,0.04420578,-0.03559544,0.02814479,0.015441926,0.013646184,-0.035880532,-0.039740216,-0.042695362,0.063621536,0.014262743,0.027067853,-0.05407194,0.04060649,0.040711123,0.011607365,-0.009963677,0.021109005,-0.021425966,0.059821192,0.042691175,-0.021655008,0.00959731,-0.051466763,-0.06592726,0.026743878,0.02379113,-0.064192764,-0.06091833,0.0054551195,0.040488675,0.0052133854,0.094444595,0.012349031 +2.4.1.256,"This eukaryotic enzyme performs the final step in the synthesis of the lipid-linked oligosaccharide, attaching D-glucose in an alpha-1,2-linkage to the outermost D-glucose in the long branch. The lipid-linked oligosaccharide is involved in N-linked protein glycosylation of selected asparagine residues of nascent polypeptide chains in eukaryotic cells.",384,0.99999994,-0.039280538,-0.023478642,-0.11513693,0.04831045,-0.005166579,-0.01395008,-0.025060575,0.029211212,0.054155614,-0.0008840593,-0.011492715,0.035965662,-0.113731936,-0.009219981,-0.057281025,-0.049610086,0.0037448686,0.012681678,-0.017533923,-0.038680434,0.08033516,0.026440801,0.061884575,-0.0385166,0.07307444,-0.0989557,0.048177943,-0.09290038,0.01323558,-0.08925785,-0.016085649,-0.12014783,0.015367643,0.01998231,0.038700342,0.06685749,0.029634649,-0.033192735,-0.007482544,-0.06479067,0.09348502,0.022197315,0.028722387,0.012912681,-0.037664823,0.0003286842,-0.048161652,0.06512534,0.0744485,0.040611714,-0.031297147,-0.06350281,-0.06481916,-0.015917694,0.02899456,0.0999155,-0.08087393,-0.013269876,0.053566236,0.029942263,0.022637365,0.035625935,0.06043499,0.0018455617,-0.014203176,-0.1574102,0.0792927,-0.021051923,-0.097882405,0.048139576,-0.022407627,-0.018279437,-0.025492629,0.020854171,0.045016434,0.033669107,-0.085573405,-0.024476446,2.7023698e-05,-0.046086542,0.09078119,-0.0016184415,0.09997864,0.07027276,-0.07201796,-0.046993542,0.044399615,0.021348063,0.059535224,0.0124458065,-0.0139983175,-0.008867683,0.02048319,0.0002461705,-0.03408419,-0.04510757,0.08549642,0.01418224,0.023273814,-0.02852164,-0.009635176,0.020208143,0.07160546,-0.0494358,-0.03486899,0.028390793,-0.018969985,0.031323213,-0.00080117426,0.0133192865,-0.0044990615,-0.020301336,0.06333391,-0.05377084,-0.095518954,-0.011045638,-0.041709565,-0.06600211,0.006658263,-0.02428221,0.027837466,-0.0015823777,0.031359117,0.045614373,-0.04249196,0.091443606,-0.009091882,1.35351645e-33,0.08324168,-0.0023383836,0.014819869,-0.0034299276,-0.01836466,0.006733251,-0.0042363144,-0.0806844,-0.03147223,0.009745339,-0.076913886,-0.097870104,0.01958342,0.117002584,0.029705217,-0.0043151653,0.045415413,0.010399457,0.037386023,0.0066013266,-0.0039339205,0.08423858,0.005525509,-0.031049304,0.073183715,0.0027247916,-0.04664998,0.048796244,0.0723468,0.0053164526,0.04676809,-0.05560397,-0.12023339,0.030012434,0.10455147,0.004511584,-0.011528932,-0.05173024,0.033866614,0.0049736747,0.0035350698,0.011431174,0.028425973,-0.101876594,-0.041688446,0.043140292,-0.041294184,0.019754615,-0.024982845,0.08653723,-0.004568492,-0.02886949,0.043488756,0.05738904,-0.018823354,0.029752785,-0.07765861,-0.047279783,-0.0054629743,0.06935247,-0.019204378,-0.027068794,-0.050264183,-0.012924877,0.02069083,0.03229566,-0.083187334,-0.00476532,-0.019598458,-0.038188796,-0.07128379,-0.08125249,0.06442213,0.017444745,-0.03314492,-0.03404772,-0.05991354,0.028627079,0.01110321,-0.044110358,-0.00075153477,0.055584237,-0.050218843,-0.06500098,0.0024970407,0.051239796,-0.067559704,-0.043317307,-0.048701286,0.046635807,-0.044184603,-0.034433555,-0.037578706,0.07016552,0.01405855,-5.1154285e-33,0.06353509,-0.07042944,0.12480574,-0.025564918,-0.07531958,0.038373876,0.028651511,-0.062530726,0.023762167,0.0068182475,0.037008613,0.050523773,0.010086732,0.0034537911,0.018737784,0.008188423,-0.0730351,0.1362277,-0.03418709,-0.039160144,-0.017780142,0.010355573,0.0067069684,0.034102388,0.052480813,-0.01834683,0.0012963427,0.030620307,0.00083950494,0.032775965,0.01992177,0.009417148,-0.058174808,-0.019552113,-0.063682266,0.023128925,-0.00952527,-0.060473874,-0.009390373,-0.046590377,0.03454656,0.06406803,0.04408063,-0.021393867,0.08405878,-0.0027681142,-0.07639431,0.07427694,-0.06156874,-0.06824139,-0.06615534,0.009850879,0.04341943,0.03166738,-0.0037210356,0.07842347,0.0941575,0.060203675,0.015441177,-0.060833003,-0.005549278,-0.056802914,0.11015258,-0.033137098,0.06343852,-0.0006826311,0.017927168,-0.0195851,0.021762278,0.028983824,-0.05290385,-0.008111111,-0.011275503,0.02626163,0.0033973511,-0.037229873,-0.074393675,-0.046789158,0.022182727,-0.031036701,0.034615446,-0.0039074696,0.006218762,-0.07866075,0.06668978,-0.075231865,0.11107842,0.104638085,0.002888153,0.061461944,-0.013180888,-0.06871287,0.009937992,0.0641089,0.059645742,-3.861747e-08,0.050264645,0.002705059,-0.030231826,-0.08740025,-0.06135792,0.013192605,-0.036040004,0.013548867,-0.017226996,-0.021721434,-0.0066577015,0.13707308,0.0038684597,0.027003609,-0.050264176,0.07008337,-0.083323024,0.008413114,0.021196699,0.066905156,-0.08311291,-0.0057688286,-0.11971076,0.06536847,-0.005936868,-0.083363906,0.058462344,0.07520699,-0.0038074674,-0.020146025,-0.0041910023,0.06359818,-0.020978017,-0.06348599,-0.01616538,-0.025914928,-0.030301543,-0.019811938,0.026202291,0.005479511,0.04663268,0.008083183,0.03187304,-0.02008335,-0.0050621997,0.07423437,-0.009916925,0.010930237,-0.15286985,0.059330158,-0.048376545,-0.0085524125,-0.044856656,-0.09187095,-0.055885423,-0.039846204,-0.10142768,0.00094076357,-0.025391653,0.016756404,-0.020860316,0.016026348,0.10040027,-0.047319334 +2.4.1.257,"The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha1,3-mannosylation (cf. EC 2.4.1.132) of beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol, followed by an alpha1,6-mannosylation, to form the first branched pentasaccharide intermediate of the dolichol pathway [1,2]. 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Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate. The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalysed by ALG3. 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Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate. ALG9 mannosyltransferase catalyses the addition of two different alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to Man6GlcNAc2-PP-Dol (EC 2.4.1.259) and the addition of alpha-1,2-mannose to Man8GlcNAc2-PP-Dol (EC 2.4.1.261). 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Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate. 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Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate. ALG9 mannosyltransferase catalyses the addition of two different alpha-1,2-mannose residues: the addition of alpha-1,2-mannose to Man6GlcNAc2-PP-Dol (EC 2.4.1.259) and the addition of alpha-1,2-mannose to Man8GlcNAc2-PP-Dol (EC 2.4.1.261). ",384,1.0,-0.027331347,-0.06642532,-0.055278454,-0.02029702,-0.014995997,0.017716618,-0.00052309624,0.020235104,0.0074233455,0.07604577,0.0188877,0.034579873,-0.07085182,0.01697854,-0.054848235,-0.045494206,-0.02236153,0.016763665,-0.015462738,-0.019966798,0.09675674,0.015106032,0.034718502,-0.031230202,0.042058613,-0.06974623,-0.037571143,-0.012342568,0.022360912,-0.098041065,0.0130502945,-0.045649044,-0.030613638,-0.030060703,0.045484703,0.035258334,0.04114153,-0.005132761,-0.00023907158,-0.049181275,0.030891199,-0.060643334,0.008658395,0.003960587,-0.048707776,0.02538441,-0.017529896,0.07743343,-0.007719405,0.10850838,0.0012490255,-0.016367983,-0.03046257,-0.014891991,0.036010843,0.07765057,-0.04255892,0.044221606,0.048575412,0.062425222,-0.061345227,-0.00087051943,0.051129553,-0.027457094,0.006301803,-0.07423489,0.08386763,-0.07558909,-0.024274018,0.017189113,-0.009464253,-0.06413693,-0.036582857,-0.08316052,-0.0082751205,0.0756613,-0.048277494,-0.005141144,-0.015305132,-0.0053754053,0.11172546,0.06133865,0.07247398,0.03704588,-0.04466249,-0.026058936,-0.03694328,0.057386793,0.0316618,0.0022630803,0.0037540616,-0.034580458,0.06890615,-0.030553946,0.017689409,0.03585347,0.0015039931,0.043886013,0.005227057,-0.010253432,0.030100446,0.0023500596,0.05762526,-0.09189323,-0.01604459,0.060532056,-0.013364421,0.039366547,-0.021350108,0.019007398,0.01596242,0.06795704,0.03644829,-0.048236102,-0.08713645,-0.016683307,-0.04763665,-0.07983146,-0.017022,-0.06265269,0.0054314747,0.008845806,0.032765497,0.049706697,0.00077117846,0.021674037,0.0022568882,6.280284e-33,0.03560238,0.023917684,0.047973715,0.073974706,0.020372668,0.0029875457,-0.034538742,-0.02768832,-0.07949577,0.0014301834,-0.06387555,-0.026389424,-0.037789475,0.09796324,-0.06052482,0.06221769,0.029978521,-0.009371444,-0.009428536,-0.027199876,-0.030322393,0.05282839,0.023293514,-0.03275958,0.15758526,0.1255518,-0.06597373,-0.013384318,0.040843535,-0.0455796,0.043767616,-0.046551134,-0.054998145,0.0064583807,0.04913195,0.027174626,-0.059885934,-0.039469622,0.028496012,0.0458826,0.008996692,0.05296773,-0.074867494,-0.05447951,0.046568155,0.014073032,0.037707713,0.019636419,-0.0053451913,0.03806851,0.029883303,-0.049700294,0.020346915,0.041224256,-0.0914184,-0.002595197,-0.057603415,-0.04650011,0.0001001747,0.10219776,-0.00018967995,0.026044253,0.0075451853,-0.049095746,0.012344639,-0.033203986,-0.06286724,0.02922307,-0.012272447,-0.02057769,0.015767237,-0.069817275,0.12733984,0.045684014,0.035504058,-0.029713333,0.0060640154,0.045743152,-0.0136751635,-0.018673578,0.078572415,0.03005436,0.0069828886,-0.014476321,-0.063716024,0.014241919,-0.05274192,-0.10652033,-0.06795922,0.053405974,-0.02839117,-0.026939658,-0.072794326,0.079848915,-0.0573615,-8.122035e-33,0.12296495,-0.071668915,0.082830966,-0.05657016,-0.066414915,0.003923239,0.07699708,-0.08257321,0.03486607,-0.009584484,0.05927699,-0.04342867,0.07702068,-0.06578743,0.028500186,-0.09197868,-0.020401938,0.11109227,0.014369575,0.019576835,0.011256432,0.049120124,-0.008718407,-0.019954944,0.046302285,-0.043466024,0.045328174,0.04700225,0.026714213,0.0713393,-0.045435157,0.02220585,-0.07398928,-0.04615242,-0.00030229223,-0.03533402,-0.085983455,0.090563364,-0.028764715,-0.018556934,-0.0049744393,0.076026715,0.04623588,-0.100907356,0.07715129,0.06443342,-0.08128881,0.013743847,-0.07091405,-0.046569496,0.0079874005,-0.015045576,-0.09411258,0.020301223,0.040042315,0.09137718,0.05830315,-0.006526869,0.03695062,-0.05483551,-0.0899953,-0.007927988,0.08536162,-0.012098177,0.007696722,0.093219094,0.013132985,-0.031243986,0.04033068,-0.015858117,-0.015950657,-0.030765159,0.005793194,0.016034609,0.025657848,0.03306193,-0.13002856,-0.059124183,0.018873705,-0.089421935,-0.008561269,-0.057296984,0.024071494,-0.014932626,0.07310033,-0.044876907,0.097656675,0.12981908,-0.020178812,0.069952026,-0.038699124,-0.022291418,-0.047748245,0.030480158,0.0215335,-5.7044872e-08,0.049976084,-0.006889186,0.047837533,-0.102347754,-0.006127517,0.010154914,0.057201173,0.04979703,0.0051444066,-0.004612411,0.010867098,0.054625552,-0.0052340585,-0.006324201,-0.023586739,0.073187724,-0.1195103,-0.02957046,-0.022267576,-0.023399577,-0.1266685,0.0062717074,-0.030882822,0.05582546,0.022706013,0.0035611219,0.040828943,0.075478986,-0.0036572851,-0.0045531397,0.08529142,0.0033462895,-0.059416085,-0.09086627,0.01655808,-0.06136658,-0.0046562073,0.013306804,0.03974183,-0.010283634,-0.060868505,-0.023864249,0.041588232,0.00074977515,0.0009491785,0.011521491,-0.037742656,0.041158907,-0.05514726,0.09655764,0.050423373,0.0045691133,-0.09781361,-0.11704001,-0.086083315,-0.10654034,-0.0073170275,0.0013093022,-0.0049366537,-0.044414595,0.024157366,-0.048507728,0.07703118,-0.07721463 +3.1.2.29,"Fluoroacetate is extremely toxic. It reacts with CoA to form fluoroacetyl-CoA, which substitutes for acetyl CoA and reacts with EC 2.3.3.1 (citrate synthase) to produce fluorocitrate, a metabolite of which binds very tightly to EC 4.2.1.3 (aconitase) and halts the TCA cycle. This enzyme hydrolyses fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance on the organisms that produce it. It has been described in the poisonous plant Dichapetalum cymosum and the bacterium Streptomyces cattleya, both of which are fluoroacetate producers.",384,1.0,-0.024921736,-0.049086347,-0.080673546,-0.0126662515,0.034655146,0.016186537,-0.045325898,0.13914984,0.019405384,0.012864227,-0.02556541,-0.10920842,0.034960963,0.0072130715,-0.0997825,-0.03864096,-0.022116637,-0.02918033,-0.022600062,0.0049133874,0.038756087,0.04289881,-0.02589945,0.05273532,-0.0017482156,0.008651798,-0.051502284,-0.0027875516,-0.008283696,-0.0942593,-0.031349715,0.0071309856,0.008989206,-0.046784595,0.004407376,-0.018887455,0.029088393,-0.083777115,0.080219,0.027074004,-0.050088592,0.04809965,0.007460547,-0.013223098,0.019667234,-0.04110248,0.0013656375,-0.037454013,0.069686346,-0.00078484556,-0.052770082,0.015109268,-0.013192032,0.0711735,0.023778584,-0.032514844,0.038968973,0.009763429,-0.032567736,0.049902633,0.04882474,-0.010679808,0.025334515,-0.0033025406,0.023962723,-0.022742167,-0.049175,0.017229486,0.04336705,-0.0061351643,-0.073994644,-0.04782976,0.049993888,0.004465447,-0.0021233663,0.15865172,-0.019952098,0.010946027,0.0055766217,0.018695673,0.039399523,0.018288516,0.10459282,0.02628072,0.08420982,-0.017080521,-0.03467257,0.01587589,0.021505745,0.08379541,0.05366069,0.097229764,0.057085674,-0.012082095,-0.07595103,0.08733344,-0.01783067,-0.030802635,0.0028990048,0.00077949907,0.0062876623,0.042034145,-0.00939899,-0.024668049,-0.011888172,-0.015756076,-0.09840242,0.049091615,0.012446013,-0.0378963,-0.037358083,0.005485622,-0.035250075,-0.02242979,-0.023683067,0.071298845,-0.015376426,-0.10029606,-0.037073076,-0.031289555,0.06372401,-0.09908335,-0.0130496165,0.058202885,0.06953097,-0.0041094036,-0.05584194,3.5390726e-33,0.037161466,0.034665532,0.046408843,0.014848617,0.035765193,-0.03495517,-0.033518106,-0.0041363854,-0.05686781,-0.074342415,0.030672338,-0.044790108,0.018871907,-0.025013834,0.003156926,-0.03132151,-0.015268321,-0.060056243,0.03823047,-0.052395068,0.122643374,-0.014215065,-0.0040088585,-0.039623797,0.016898997,0.043613255,-0.09419406,0.06345395,0.021387035,0.023451397,-0.020964334,-0.09542056,-0.045132075,0.005984807,0.037324883,-0.11607044,-0.12385487,-0.043925744,-0.04963291,0.07840967,0.040508334,0.020317638,0.036805265,0.024904527,0.12266668,-0.0012094696,-0.03977948,0.042290375,0.027335212,0.010798064,0.0122082755,-0.018386185,0.0819863,0.008789224,-0.018751185,0.031083267,0.040434822,-0.07906214,0.045679085,0.06468197,0.0018644365,0.096509084,-0.07704403,0.03644012,-0.06532097,0.007278896,-0.050986215,-0.02579615,0.027702963,0.08302052,-0.0086097615,-0.06405251,-0.04060919,0.02981859,0.036576036,-0.07913159,-0.0702499,0.034035612,-0.025936725,-0.013783678,0.052346352,-0.064695366,-0.038376763,0.021724198,-0.09629948,0.0018553984,-0.008984811,-0.031802855,0.016300427,0.07109887,0.089513905,-0.04038383,0.03239189,0.012828197,0.018056404,-3.1183566e-33,0.05700429,-0.048514143,0.06537014,-0.049410846,-0.06107801,0.018178338,-0.034778878,0.011852298,0.12193313,-0.027267216,0.03218897,0.011874271,-0.0056684692,-0.006519756,-0.05318558,-0.010098391,0.123892814,0.03998382,-0.040595986,-0.058176167,-0.004137932,0.0031183471,-0.003015198,0.025990222,0.01443986,0.047454707,0.027298955,-0.048338335,0.0549175,0.0051800157,-0.0031270245,0.092172034,-0.025159067,-0.0145428525,-0.07094602,-0.06322097,-0.040984765,-0.016901452,0.0026377894,-0.009281706,0.056844544,0.107503705,0.09937676,0.046419233,0.036731094,0.08848014,-0.10208622,-0.0020236797,0.01290696,0.020799957,0.021104662,0.055019565,-0.015579751,0.057612475,0.046534967,9.812279e-05,-0.017877148,-0.05314183,0.02544777,0.013914285,0.003290339,-0.07076633,-0.08196656,-0.05243993,0.11879498,0.009434961,-0.065794066,0.11652393,0.07662768,-1.7125487e-05,0.11023218,0.02582062,-0.036029454,-0.020698462,-0.05597624,0.010023548,-0.07849702,-0.007968618,0.041030712,0.0029745698,0.00077086414,0.007638217,0.0014748604,-0.038117085,-0.06010837,-0.08491293,-0.019626435,0.10484506,0.006439365,-0.017607138,-0.04118722,-0.08550346,0.008468306,0.0558977,0.10391493,-4.077698e-08,-0.0047696065,-0.09938056,-0.0480402,-0.019344969,0.0063983216,0.022602681,0.008717503,-0.035227213,0.041500848,0.0046321065,-0.026356982,0.06181312,0.060178846,0.0077103092,-0.07582676,0.056186583,0.06004937,-0.00638895,0.0115046995,0.045891754,-0.061867744,-0.015228283,-0.08622021,0.027345264,-0.013996207,-0.049131874,0.058938067,0.030128585,0.022188304,0.022846494,-0.06860654,-0.010051812,-0.009908378,0.013193638,-0.10714463,-0.0386435,-0.014754826,-0.043794572,-0.07630522,0.0018717595,0.038163744,-0.003089986,-0.06828166,-0.007410526,-0.009384476,0.0046933256,0.053184148,-0.007780826,-0.006443236,-0.093433246,0.06522479,0.0049498733,0.013471766,-0.026332226,-0.09177272,-0.012265022,0.038408816,-0.014220899,-0.035612445,-0.042796545,0.015052792,-0.09646376,0.2143924,0.050448425 +4.1.99.16,"Requires Mg2+. Geosmin is the cause of the characteristic smell of moist soil. It is a bifunctional enzyme. The N-terminal part of the enzyme is EC 4.2.3.22, germacradienol synthase, and forms germacradienol from FPP. The C-terminal part of the enzyme catalyses the conversion of germacradienol to geosmin via (1S,4aS,8aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene.",384,1.0,-0.006263169,-0.02149233,0.093864664,-0.004017077,0.14178807,-0.08404163,0.057366025,0.003703021,0.02492945,-0.02426763,-0.015217388,-0.011358836,-0.04961022,0.077756055,-0.03482355,0.024204012,-0.019993573,0.06025437,-0.03627263,-0.0012057439,0.045643613,0.08075833,0.08340656,-0.008478813,-0.055089515,-0.025689848,0.032699235,-0.01529946,0.016513484,-0.015159835,0.047672782,0.036484588,-0.027329156,-0.045018826,-0.013403879,0.124222,-0.022934964,-0.06385645,-0.00046366296,0.04698383,0.013487027,-0.05546804,0.10529245,-0.08151001,-0.045686543,-0.090226606,0.04320017,-0.02067804,0.08108483,0.015426952,-0.010864424,-0.044439893,-0.041322846,-0.035211366,-0.0019680653,-0.05575554,0.0051173414,-0.04972788,-0.113971435,-0.03484784,-0.018049195,-0.039903164,-0.06864467,-0.09202933,0.031364284,0.028490838,0.009777598,-0.057720948,0.0456096,-0.012539475,-0.0059799976,0.0037463808,-0.046331663,-0.004854985,-0.04194934,0.14657061,-0.014344264,-0.018553967,0.045596287,-0.0879923,0.08246694,0.05165032,0.021369683,0.10630352,0.05586517,0.008218112,-0.03586086,0.018125176,0.0256996,0.022520004,0.085783646,-0.015949488,-0.06669957,0.039701767,-0.08848335,0.014780196,0.012165113,0.02458156,-0.033873305,0.0076445374,-0.042503353,-0.017898243,-0.045571055,-0.014077678,-0.016453097,0.04241129,-0.04733931,0.030167496,-0.00995266,-0.012508279,-0.07259601,-0.0023744737,0.05717702,0.027134892,-0.047014054,0.014903237,0.028134547,-0.021714928,-0.07455632,0.026404394,-0.0134382835,-0.014709087,0.025576148,0.041216787,0.010170772,-0.024729677,-0.04502064,2.5842865e-33,0.0316276,0.057674337,0.09718113,-0.00024481295,-0.062764555,0.068677865,-0.11791297,0.020985795,-0.006747402,0.00959488,-0.09563737,-0.0126684625,-0.03824276,-0.0007501469,-0.0032192958,-0.03805081,-0.010858524,-0.02574807,0.06605229,-0.051383864,0.0011289743,0.06840416,-0.06269429,-0.023235235,-0.06466148,0.055308387,0.013226606,0.04286207,-0.05538256,0.0072600725,0.12022962,-0.07875914,-0.045104463,0.086935356,0.023981405,-0.026800541,0.023750182,-0.009033595,0.022222424,-0.049577374,-0.0604463,0.006806287,0.033697095,-0.021095727,0.056987084,0.006510759,-0.05413108,0.042210426,0.12482529,0.048541192,0.04429781,0.022346772,0.001558502,0.119064085,-0.069794245,0.022481864,0.033956505,-0.08266244,0.08360215,0.0117014935,0.016135879,0.08093924,0.055986658,0.013969045,0.04759765,-0.073792346,-0.03236193,-0.05843899,-0.015257722,0.12384653,0.04657021,0.01500425,0.05385084,0.12995674,-0.012535081,-0.04897207,-0.015527381,0.027438944,0.026800636,0.023763446,-0.054240264,-0.06410276,-0.046516135,0.013963402,-0.08095514,0.06247402,-0.031151736,0.04942526,0.007934757,0.021197455,-0.023226766,-0.08879859,-0.03406725,-0.07010119,-0.046501707,-3.5928342e-33,0.039467197,-0.019876832,0.02707922,-0.013953908,-0.062034845,-0.05481041,-0.01068576,0.028701581,-0.0034723154,0.08070209,0.07477051,0.051745534,0.13373774,0.014700068,0.03183263,0.010209759,-0.028884374,0.0043836934,-0.0101235965,-0.044934213,-0.0498683,0.0290839,-0.023868991,0.052773155,-0.04101295,0.025056463,0.038448956,0.016356518,-0.031324863,0.0972713,-0.06177804,0.13354748,-0.05025315,-0.049998563,-0.0069263508,-0.07798575,-0.06207596,-0.056982707,-0.019956805,-0.008343266,-0.013248823,-0.0067938752,0.1184933,0.023584664,0.041688755,0.06474167,-0.03294976,-0.01126332,0.054918963,-0.0100724995,0.02247219,0.0904994,-0.018891994,-0.0112951035,0.023537919,0.05937038,-0.011640056,-0.042719748,-0.018674934,0.060623687,0.074899375,0.03305027,0.013469477,-0.09039163,-0.019414935,0.03726019,0.013833015,0.092139035,0.08728273,0.069899544,0.011395114,-0.014494394,0.057724334,0.04317381,-0.03391697,0.03596506,-0.07621564,0.04770564,0.020972528,-0.08058213,0.027786395,-0.010334716,0.012614002,-0.04504081,0.014081457,-0.0847562,-0.038335346,0.06396057,0.047362123,-0.001621461,-0.03826176,0.016236622,-0.050234113,0.006437129,-0.01103599,-5.0336826e-08,-0.13330427,-0.079587616,0.05402158,-0.013957176,-0.03609879,0.001552602,0.038104553,-0.006060145,0.023270803,-0.03259006,-0.042971414,0.1206714,-0.09214415,-0.00095571997,-0.01203079,0.0070484257,-0.066488884,-0.02956951,-0.059880663,-0.082297854,-0.006268517,0.034904342,-0.12178173,-0.013568516,0.014463643,-0.05532943,0.013051545,0.055220768,0.033424478,-0.034933805,0.08383159,-0.033783868,-0.030415326,-0.025135228,-0.0988051,0.07531323,-0.010446471,-0.040729474,-0.017371146,-0.0924844,-0.0662794,-0.0271872,0.011027557,-0.023743415,-0.060525756,-0.037924673,0.031960335,0.026376026,-0.017605048,0.039625414,0.030986546,-0.00175487,-0.04098086,0.008043505,-0.011142189,-0.03401866,-0.017312866,-0.013546613,0.03713587,-0.03448247,-0.028316116,-0.05427261,0.023485126,-0.02056411 +4.2.3.61,Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.,384,1.0,-0.043689635,0.022204727,-0.041613217,0.025760524,0.016154462,0.0010722866,0.016632807,0.061826732,0.01144027,0.0016545628,0.070577554,0.028724676,0.0036025627,0.09394777,-0.08180638,-0.055789676,-0.05431156,-0.007323283,-0.020165991,-0.038672816,0.058345113,-0.0074884305,-0.0076057226,0.025261542,0.10778948,-0.05330067,0.0056486777,-0.05359946,0.03745745,0.0021671643,-0.0350106,0.007783034,0.020891478,0.021920383,0.004205315,0.112656325,-0.073180914,-0.024063343,-0.014854811,0.004721204,0.044931196,-0.022222972,-0.023780296,0.044594135,-0.041069902,-0.013537466,0.036529735,-0.004001154,-0.03874374,-0.008483739,-0.050230164,-0.057164818,-0.070875496,0.019653734,0.0045768837,0.024224076,-0.07804683,-0.0027521055,-0.024161972,-0.021995569,-0.03201817,0.010634161,-0.035770252,-0.021041766,0.089149304,-0.040306624,0.046965845,-0.023559973,-0.041775275,0.051515758,-0.011367183,-0.035372064,-0.0075969943,0.017122839,0.052896265,-0.0015331701,-0.04291993,0.02877991,-0.05467497,0.051337395,0.07485877,-0.0071190074,-0.040394288,0.06846793,0.022406064,0.019540606,0.03668964,-0.016440963,0.0063072606,-0.004547151,0.013003814,0.028578196,-0.09885578,-0.0057241484,0.018405672,-0.05239302,0.060744144,-0.06810147,-0.0044249967,0.0006032247,0.048494067,0.04099244,-0.019390242,0.025905842,-0.006182962,-0.028656598,0.0022041507,0.053342797,-0.041709002,0.06363722,0.051801573,0.02165192,0.101867795,0.008810968,-0.0061184075,0.15230994,0.0145019805,0.0019213121,-0.01487776,-0.0037601367,0.012950758,0.027826177,0.009668095,0.08673713,-0.066032894,0.062237248,-0.03215042,-2.7229261e-34,0.029477848,-0.036475107,0.041125588,0.06625492,-0.09641575,0.02744642,-0.053398483,-0.020556295,-0.050980967,-0.02091596,-0.07793135,-0.045934133,-0.00055911235,0.04968201,-0.03060046,0.02792433,0.047611114,-0.0053779124,0.0031562096,-0.001935931,-0.0035021387,-0.006822868,-0.0613685,0.019023512,0.009801111,0.02156808,-0.02204787,-0.02538485,0.0486248,-0.00035795692,-0.029370617,-0.025868915,-0.08827666,0.060357906,0.03291217,0.047620736,-0.01908058,-0.0040849955,0.040933367,0.0032613063,-0.07168261,0.017539952,0.012099452,-0.06417894,0.07936983,-0.06954231,-0.09431436,0.10878481,-0.022778878,0.04146491,0.06181368,-0.033921152,-0.043577522,-0.00439974,-0.079098746,0.069350295,0.012971522,0.024974545,-0.03445078,0.029185908,0.026736058,0.054122485,-0.03980176,-0.021312242,-0.015377758,0.091745645,-0.16109526,-0.07175728,-0.034677725,0.08669343,-0.070837714,-0.026379693,0.038995393,0.10155631,0.050128445,0.024731424,-0.06482558,-0.038780723,0.057551857,0.01736857,-0.027554018,-0.011408003,-0.025919704,-0.029090025,-0.08744305,-0.022014657,0.0043169395,-0.08683079,0.0007504093,0.0489909,-0.007240686,-0.029397203,0.0056629255,-0.0035308888,3.2324565e-06,-2.2359208e-33,0.07132818,-0.095985554,-0.06898777,-0.025435716,-2.0549021e-05,0.054261576,-0.035671078,-0.13809665,-0.052748054,-0.026478339,0.06075745,0.014991214,-0.06933507,-0.030976083,-0.006717503,-0.06991149,-0.02052752,0.09306384,0.06639445,0.09369845,-0.07776653,0.0048839315,0.00858587,-0.0013179948,0.052957516,0.019578237,-0.084908895,0.11270119,0.022055361,0.03267076,-0.05994346,-0.022777444,-0.048246246,-0.03856263,-0.020717569,0.06946244,-0.02774621,-0.0565063,0.024089495,0.05882057,-0.029601866,-0.05198813,0.058477547,0.046215195,0.10001609,0.06118402,0.030273693,-0.021244831,0.04164731,-0.035722267,0.051852025,0.007074894,0.036147602,0.019757245,0.009691841,0.09867083,0.07876443,0.011218245,0.03599214,-0.07889428,-0.004466507,-0.022926036,-0.021826088,-0.104464225,-0.02165696,-0.01301402,-0.009541728,0.13554133,-0.018068038,-0.058997877,0.09377397,0.05797684,0.057903204,-0.03186458,-0.050913855,-0.0067711454,-0.067887045,-0.04818615,-0.024069887,-0.12854575,-0.052729122,0.1031612,-0.04153831,-0.07650395,0.030872656,-0.099600576,0.06253255,-0.012354681,-0.017532635,0.012765442,-0.00905736,0.02248547,-0.0032923252,0.05458436,0.06716111,-2.8151963e-08,0.049182642,-0.018411472,-0.072295815,-0.045038655,0.023017434,0.0020086379,0.018023307,-0.019465877,0.015303386,-0.036491033,-0.07935381,0.090175115,0.017639898,0.012751619,0.043224078,0.037557308,-0.06165112,-0.058876403,-0.0688607,-0.07280195,-0.0872178,-0.009718688,-0.13541535,-0.03958746,-0.041016914,-0.111172065,0.07289166,0.020427436,0.014306147,0.007569643,0.020351775,0.046517536,0.05763266,0.07255611,-0.07989074,0.0297836,-0.0022232316,0.04674585,0.00800047,-0.05569324,-0.03512529,-0.024288872,-0.07835939,-0.0081935115,0.014537036,0.017647773,0.04819865,0.0022629604,-0.041458726,0.10488413,0.060957965,0.021558696,0.04460959,-0.0050972663,0.027019272,-0.02502844,0.016065497,-0.039206147,0.021807436,-0.056533366,-0.0929475,0.016448537,0.18275236,0.03936063 +4.2.3.62,Isolated from the liverwort Heteroscyphus planus. cf EC 4.2.3.92 (+)-gamma-cadinene synthase.,384,1.0,-0.025346326,0.0011897548,-0.12554207,-0.024508765,-0.047755565,0.03563567,-0.05048991,0.033530954,0.012791556,-0.0050319587,0.038111772,-0.055640213,-0.038601007,-0.027544243,-0.04461315,-0.004940419,-0.067851424,-0.058890942,0.020164574,-0.067441285,-0.026598863,0.03889756,-0.032992087,-0.05112102,0.00046689488,-0.04136768,0.06280263,-0.0013783211,0.018620793,-0.082461536,-0.035599377,-0.024792997,-0.03261489,-0.04674141,0.021378705,-0.00037630336,-0.008439186,-0.0133992545,0.05970471,0.058148943,-0.0044602375,0.045254365,-0.020419056,-0.032982018,-0.090862535,-0.010937532,-0.09865156,-0.008385654,-0.007070599,-0.03037314,-0.05024818,-0.077354886,0.0058472203,0.08486779,0.09190807,-0.08420219,0.019781427,-0.035858616,0.050782222,0.0025167572,-0.0026896663,0.03842216,0.06805292,-0.08940188,-0.09320019,0.039634533,-0.020827353,0.035478644,0.011467528,-0.023172919,-0.018305494,-0.03556765,-0.06934617,0.014211773,-0.059754033,0.10950952,-0.038253274,0.01669773,0.10867464,-0.0014106473,-0.06666539,0.0052491305,0.021394143,0.07056488,-0.011267036,0.0021270146,-0.0065903612,0.09870463,0.045699887,-0.026452387,-0.009032291,-0.0045186593,0.023560464,-0.057737853,-0.076961,0.04318704,0.034030963,-0.011243432,0.050496742,-0.031465694,0.022655634,-0.0023774644,-0.010537876,-0.06431233,-0.11352805,0.040457774,-0.005530084,0.12006875,0.07472015,-0.07801351,-0.02403625,0.022854434,-0.037311666,0.013300594,-0.09522902,0.0949139,0.024190268,-0.003906629,-0.011900276,0.028510187,0.0060507557,0.1091221,0.059415642,0.048990995,0.040754244,-0.019798784,-0.055838816,-1.875511e-33,0.06361039,0.082116544,-0.02247019,-0.02763819,0.06280005,-0.011471837,-0.072126836,0.012061278,-0.06365065,0.0070906268,-0.06716799,-0.03983684,-0.056832578,0.016624494,0.014204698,0.0009617077,0.019398509,0.043846708,-0.020907812,-0.0046563796,0.048669282,0.02018875,0.009808197,-0.0060493513,0.022324115,0.045536637,-0.021416832,0.0012079203,0.07516667,-0.009512547,-0.013350225,-0.061771154,-0.020391284,0.040231872,0.008756908,0.0242909,-0.032394197,-0.06057063,-0.033392176,0.0660742,0.10041885,0.007589672,0.0387167,-0.04811979,0.06615969,-0.008423606,-0.067518264,0.026431113,0.08340851,-0.02417138,-0.08164987,0.026082,0.09364552,-0.00012772532,-0.008668355,-0.024976825,0.025742745,-0.0052419584,0.11320307,0.035672758,0.07129826,0.0980056,-0.034749944,0.026888149,0.025243208,-0.01599003,-0.10823946,0.006039651,-0.1080169,0.010688955,-0.014868542,-0.08959295,0.03704841,-0.04142482,0.06000458,-0.032859795,-0.06484926,-0.062551364,-0.03202488,0.014200255,-0.02675515,-0.0054608015,-0.036163926,-0.060598362,0.005251219,-0.033966377,-0.026218038,0.03282808,0.008142724,0.09425629,0.028618805,0.016463963,-0.12900099,0.028325018,0.011374825,7.374125e-34,-0.00865146,-0.019547848,0.060990922,-0.06661772,-0.029614635,0.0821843,-0.038962774,0.0043865475,0.05942294,0.0039939587,0.0742808,0.039756384,0.004784786,-0.092227906,-0.040299207,-0.028521642,0.08969566,0.07342523,0.014942351,-0.040189695,-0.040022947,-0.00227112,-0.041625172,-0.0037637064,0.038857106,0.037005235,0.07400901,0.059261207,0.005501055,0.06821586,-0.011882808,0.009132719,-0.039476663,-0.04348981,0.031003466,0.007069637,-0.009756163,0.018601334,0.05983374,0.026336472,-0.052073024,0.022797743,-0.0034228864,0.09827559,0.07794687,0.10492375,-0.047840994,0.036306154,-0.00136298,0.061395798,0.04976921,0.038189337,0.007278198,-0.02214185,0.014474805,-0.071940415,-0.0009350899,0.04218903,0.062776044,-0.056390956,-0.016646253,-0.020646773,-0.023599867,0.0136335,0.020374542,0.13565388,-0.040202364,0.02897732,0.06291579,-0.043881048,0.028203294,-0.05297935,-0.008904384,0.062092934,0.025501484,-6.2199083e-06,-0.0073010256,-0.06853562,0.061690837,-0.05773071,0.06116996,-0.06365856,0.08296504,-0.064587235,0.04496384,-0.01819272,-0.016077723,0.10640143,0.03419398,0.03832997,-0.061380215,0.050946984,-0.09043428,5.2167063e-05,0.059395097,-2.8744926e-08,0.008944542,-0.033088863,-0.036376774,-0.00856835,-0.012455281,-0.058250066,0.012531936,-0.021721829,0.10526629,0.021932907,-0.026116928,0.030282943,-0.012562601,-0.034501523,0.038848367,0.023045285,0.031433895,0.04948438,0.039150987,0.06065328,-0.038833104,-0.039420962,-0.003706979,-0.037512254,-0.054971766,-0.102689505,0.072503865,0.001610117,0.03979679,-0.011396408,0.0067443447,0.11112189,-0.031887066,-0.00079222466,-0.050750796,-0.0053541022,-0.07252497,0.041918207,0.07392894,-0.015125118,0.0047739777,-0.020490821,-0.09751541,-0.044138096,-0.033458695,0.0033966794,0.014989953,0.002891556,-0.017941492,-0.035328943,-0.015207099,0.0077731274,0.13151439,-0.07564421,-0.08151196,-0.014678929,0.029950742,-0.069725566,-0.065637834,-0.108265996,-0.024794633,-0.06043343,0.20035942,0.01225984 +4.2.3.63,Requires Mg2+.,384,0.99999994,-0.07665402,-0.038054194,0.039842892,0.031238493,0.0070963134,-0.10816706,0.031396363,-0.012718671,-0.08823646,0.016668653,-0.011627114,0.009235351,0.020469403,0.027300078,0.07519512,-0.028448183,0.0715019,0.07045796,0.018434891,0.026004534,0.08494145,-0.065659486,0.068798766,-0.03082152,-0.0004967447,0.054926157,0.012391702,0.00039817864,0.076728836,-0.019847216,0.02548439,0.035734635,0.0310051,-0.078315675,-0.01352614,0.04934156,-0.005067076,0.024699766,-0.06924375,-0.064533435,-0.021464918,-0.017321508,0.08574613,-0.005009904,0.060631067,-0.10964332,0.060357597,-0.058503002,0.06537732,0.04956052,-0.03117558,-0.017741079,-0.072908066,0.03095435,0.03766954,-0.009370341,-0.10099469,-0.0024208706,0.007920707,0.019226445,-0.067429334,-0.032751814,-0.06933643,0.03259375,0.080561645,0.05864514,0.053334035,-0.07781461,0.004700559,0.051632058,-0.0173287,-0.0061611678,-0.03207924,-0.009767143,-0.07479019,0.03434011,0.055214845,-0.089964695,0.08863219,0.02448356,-0.050569862,-0.022054214,0.047127828,0.05811863,0.063060425,0.002712195,0.039657038,0.014420478,-0.03706183,0.06097452,0.07090591,0.04541628,0.04891299,0.08253563,0.013052929,0.019792661,-0.08355962,0.0032978384,-0.08573205,0.09359032,-0.045618173,0.039037816,-0.02772882,0.04871542,-0.020781428,-0.029908024,0.013491341,-0.02651298,-0.035007663,0.045513503,0.081580594,-0.018673517,0.005018927,0.0146132475,0.020897195,0.039241415,-0.02197236,-0.03945081,0.009004924,0.011963388,0.019130673,-0.014107881,-0.037270237,-0.016893052,-0.037506446,-0.039712057,0.0353421,-2.1798329e-33,-0.027601603,0.0140434615,0.04576148,0.05390711,-0.06005449,0.062485173,-0.058686648,-0.032427352,-0.014660152,-0.037069272,-0.08543498,-0.026043922,-0.08139896,0.04526424,0.07113395,-0.09182484,0.06882343,0.03848701,0.115479074,0.0052238083,-0.010956969,0.034465734,-0.014119359,-0.0423224,0.02411397,0.17470993,0.07107211,-0.07827463,0.0875872,0.04722923,0.037748225,-0.09870932,-0.03667781,0.032060154,-0.018318966,0.052560978,-0.07661886,-0.049213335,-0.00026230342,0.0028008446,-0.07865894,0.054327648,-0.10117837,0.022383008,0.02302489,-0.09911324,0.08207951,0.0053274455,-0.0322798,0.06118504,0.024755096,0.033496063,-0.06286064,0.083363324,-0.043899707,0.04736418,0.028306028,0.04031699,0.11027968,0.046138123,-0.0016569493,-0.00411104,0.10042004,0.060446855,0.069308616,0.026695251,-0.092058934,-0.023190055,-0.0498307,0.023541313,-0.0029367907,-0.05611692,0.092524484,0.035232756,0.01779589,-0.008103461,0.018579708,-0.016150275,0.0069402065,0.0055573876,-0.11640325,-0.041648567,-0.005572167,0.03088874,-0.035401717,-0.027392223,-0.028179616,-0.04700245,0.0059568747,-0.029995872,0.007707415,-0.039337717,-0.02237023,0.027051602,-0.05359215,2.7866728e-33,-0.02090313,-0.017748967,0.004132615,0.01955926,-0.049979042,0.01646382,0.008031828,-0.14540395,0.007715244,0.08280203,0.036767755,0.04653576,0.011842138,-0.052759882,0.057296634,-0.050051037,0.012251545,0.0067296005,0.013324272,-0.04128831,0.05649828,0.10716567,0.04169956,0.046919834,0.023433384,0.065133154,0.0025441311,-0.0044658342,0.024757596,0.03297009,0.05001582,0.08478838,-0.07848676,-0.046241123,-0.0632675,-0.0045885984,0.06861389,0.020029508,-0.076970086,0.03877496,0.033422783,0.062037226,0.04214931,0.11188784,-0.0038113294,0.013874944,0.111694604,0.011864568,0.078343265,-0.007844934,-0.023419036,-0.03684182,-0.0602447,-0.06219275,0.005339782,-0.07462539,-0.03457196,-0.027687255,-0.0014186071,-0.042227298,0.049035273,-0.052302457,0.023130903,-0.108851425,0.001723338,0.02487514,0.033778027,0.036095917,0.00808369,0.0757637,0.03264802,0.05369952,0.10054176,-0.039906617,-0.016114393,0.10003962,-0.03639271,-0.0053914115,0.084508836,-0.15106791,-0.016808104,0.006093106,0.0022322417,-0.033104945,0.02303368,-0.14249355,0.00066597154,0.032624956,-0.0062381355,0.016638314,-0.05376237,-0.008983198,0.020185422,0.04328513,-0.053632196,-1.5045867e-08,-0.058269307,-0.01017092,0.0484067,-0.024861336,0.009951786,0.07073473,-0.047450934,-0.012480189,0.053076956,0.031953312,0.063880056,-0.04596793,0.0048889574,0.020569067,-0.0023120856,0.017521104,0.0055658123,0.0070514716,-0.08998936,-0.090588704,-0.066635765,-0.069542155,-0.02578599,0.026131134,-0.01574182,-0.030586915,-0.0010515756,0.053638335,0.029773692,0.048620746,0.0016094678,-0.02033458,0.005388878,-0.01641896,-0.024181817,0.018007878,-0.0045449366,0.040687155,-0.0051154187,-0.107266635,-0.059173495,-0.002009884,0.08951511,-0.00956784,-0.06212722,0.0075910967,-0.027065925,-0.04456427,-0.064876266,0.007935584,0.060038697,-0.0269716,-0.021648392,-0.006265519,-0.0036868185,0.030736357,0.049995434,-0.013521261,0.009007248,-0.07116385,0.0399236,-0.060815267,-0.035566926,-0.033335425 +4.2.3.64,Requires Mg2+. In the bacteria Streptomyces and the liverwort Heteroscyphus the (+)-isomer is formed in contrast to higher plants where the (-)-isomer is formed.,384,1.0,-0.05324563,-0.056834046,-0.049462244,0.015577367,-0.007929627,-0.007929343,-0.052352414,-0.006439142,0.015802791,-0.015512828,0.11920146,-0.06663688,-0.0027084267,-0.023539681,-0.012038944,-0.07044908,-0.041359987,0.071882606,0.0018671923,-0.05261297,0.0729644,0.040017072,-0.03673344,-0.070424095,0.06695879,-0.015856987,-0.049011655,0.037793607,0.11650456,-0.06855073,0.041927706,-0.0012915607,0.1125846,-0.13256381,0.03366389,0.0595951,-0.008236703,-0.033383433,0.051628344,-0.0005619236,-0.019960266,-0.009430728,0.05816577,0.014766106,-0.08163492,-0.04544151,0.04925179,0.0009313341,0.025383953,-0.056193784,-0.020438345,-0.044789974,-0.11991279,0.056773707,0.039350335,-0.03637285,-0.02992105,0.02907664,-0.008469915,-0.11000358,-0.0029210756,-0.0023142106,0.0010309023,-0.05733772,-0.028219143,0.015424912,-0.007708526,-0.036193077,0.036737807,0.04102189,-0.02038062,-0.050870813,-0.06344713,0.026243627,-0.09836162,0.09720027,-0.029523456,-0.049633473,-0.00070062396,0.06619135,-0.012322881,-0.011224512,0.052713756,0.06282767,0.0011553691,-0.022876963,-0.022653133,0.036118016,-0.04722073,0.060974475,0.08312717,0.034652997,0.04267077,0.0017032815,-0.01636564,0.028895034,-0.035998087,0.032844402,0.02010946,-0.022615178,-0.034758393,0.029349513,-0.08581333,-0.0030640834,-0.030058773,0.0038831595,-0.053204156,0.036654305,0.037598,0.015810983,0.015038588,-0.0011694011,-0.022508362,-0.015255817,-0.025780184,0.035740606,0.077320665,-0.079646744,-0.044359844,-0.005046258,-0.020759491,0.04379242,-0.004371216,0.027162477,0.0130835865,-0.015790649,-0.05177286,2.2268944e-34,0.013208712,0.059769735,0.046607472,-0.021406682,-0.0040557124,0.014647733,-0.09802883,-0.036696024,0.028130928,-0.046304543,-0.122422814,-0.0881127,-0.035359725,0.014570324,0.008969402,-0.011894503,-0.029343111,0.020317039,0.07283303,0.005285629,-0.024502425,0.030022802,-0.033420827,-0.01744343,0.040054172,0.10011324,0.06065344,-0.07148371,0.038278017,-0.016485,0.04381578,-0.101158924,-0.045579072,0.07046986,0.065422505,0.044990372,-0.03038516,-0.01913955,-0.021818914,-0.0021181898,-0.049886327,0.056514025,-0.03508359,0.00951937,0.13902244,-0.059820384,-0.039348483,0.04589915,0.035530616,0.11134022,-0.009957059,0.023860194,0.04480443,0.045839615,-0.03349415,0.015722888,0.034434713,0.069382355,0.030942822,0.014147888,0.02078321,0.0771858,0.070449516,0.08422563,0.091788016,0.07006793,-0.10846639,-0.017510986,-0.02545082,0.08801414,-0.051571134,-0.11564079,0.014613953,0.05202434,0.029284596,-0.032401122,-0.08150344,-0.01898925,0.014366255,0.00075214665,-0.07957639,-0.0036708333,-0.056127068,-0.11744146,-0.09585501,0.014745439,-0.07677445,-0.0026088562,0.049512275,0.07085658,0.08588792,-0.012551597,-0.10246334,0.0676834,0.017151752,-1.9860973e-33,0.059829634,-0.031301048,0.036250416,-0.01897875,-0.107405074,0.047556974,-0.027083565,-0.11680222,0.013678997,0.032890283,0.07051682,0.042526923,-0.090535276,-0.023642978,-0.043541256,-0.13116412,0.071896344,0.10141284,-0.028897613,-0.0010077048,-0.033076007,0.08907807,-0.009357957,0.0385708,0.050192054,0.021897985,0.020321406,0.05417832,0.0222549,0.06505665,0.059643067,0.04806659,-0.0435716,-0.07366832,-0.02096542,0.044082325,-0.06249354,0.05423818,0.039415427,0.028773323,-0.0031103566,0.011431511,0.069998056,0.11095985,0.05314534,0.0055528632,-0.034773603,0.026892046,0.054344475,-0.050751925,-0.0035486366,0.019938732,-0.04600832,0.005545904,0.053010877,0.008497258,-0.050393537,0.034591883,-0.0017116077,-0.0270518,-0.0062012123,-0.036136515,0.028898869,-0.07378068,0.010597236,0.034995995,0.025223382,0.04687291,0.06079026,0.004700248,0.018325077,0.01601698,0.028327195,0.050346598,-0.033166934,0.021565467,-0.0076563926,-0.025467787,-0.006029704,-0.07855411,-0.046104345,0.001946549,-0.006925777,-0.017229097,-0.00050737686,-0.13010201,-0.048092376,0.0781972,0.013996942,0.04290952,-0.05815256,0.006920789,-0.02847277,-0.017020201,0.0130765755,-3.4088078e-08,-0.0361434,-0.020982375,0.025312698,-0.032866918,-0.0088013075,0.01989018,-0.07195903,-0.06348085,0.057454094,0.016943268,0.0325061,0.03206402,-0.026790608,-0.03722181,0.043046653,-0.009317277,-0.015760902,0.007549211,-0.018678758,-0.019125782,-0.11549779,-0.07024638,-0.10826297,0.004683797,0.03797697,-0.050013185,0.056557864,0.062723696,0.036724027,0.061655466,0.12720565,0.038218528,-0.021594565,0.022717709,-0.06497714,0.022163372,-0.05080001,0.034521427,0.037641276,-0.06862692,-0.029736124,-0.030066648,-0.05211661,-0.0075784237,-0.047517274,0.057756767,-0.021694079,0.015681187,-0.09964793,0.002207854,0.05531308,-0.062096868,0.056404926,-0.013498058,-0.033654124,0.022937726,0.0794746,-0.0024625256,-0.040167585,-0.01829229,0.022386543,-0.049163792,0.10238407,-0.014784449 +4.2.3.66,Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.,384,1.0,-0.043689635,0.022204727,-0.041613217,0.025760524,0.016154462,0.0010722866,0.016632807,0.061826732,0.01144027,0.0016545628,0.070577554,0.028724676,0.0036025627,0.09394777,-0.08180638,-0.055789676,-0.05431156,-0.007323283,-0.020165991,-0.038672816,0.058345113,-0.0074884305,-0.0076057226,0.025261542,0.10778948,-0.05330067,0.0056486777,-0.05359946,0.03745745,0.0021671643,-0.0350106,0.007783034,0.020891478,0.021920383,0.004205315,0.112656325,-0.073180914,-0.024063343,-0.014854811,0.004721204,0.044931196,-0.022222972,-0.023780296,0.044594135,-0.041069902,-0.013537466,0.036529735,-0.004001154,-0.03874374,-0.008483739,-0.050230164,-0.057164818,-0.070875496,0.019653734,0.0045768837,0.024224076,-0.07804683,-0.0027521055,-0.024161972,-0.021995569,-0.03201817,0.010634161,-0.035770252,-0.021041766,0.089149304,-0.040306624,0.046965845,-0.023559973,-0.041775275,0.051515758,-0.011367183,-0.035372064,-0.0075969943,0.017122839,0.052896265,-0.0015331701,-0.04291993,0.02877991,-0.05467497,0.051337395,0.07485877,-0.0071190074,-0.040394288,0.06846793,0.022406064,0.019540606,0.03668964,-0.016440963,0.0063072606,-0.004547151,0.013003814,0.028578196,-0.09885578,-0.0057241484,0.018405672,-0.05239302,0.060744144,-0.06810147,-0.0044249967,0.0006032247,0.048494067,0.04099244,-0.019390242,0.025905842,-0.006182962,-0.028656598,0.0022041507,0.053342797,-0.041709002,0.06363722,0.051801573,0.02165192,0.101867795,0.008810968,-0.0061184075,0.15230994,0.0145019805,0.0019213121,-0.01487776,-0.0037601367,0.012950758,0.027826177,0.009668095,0.08673713,-0.066032894,0.062237248,-0.03215042,-2.7229261e-34,0.029477848,-0.036475107,0.041125588,0.06625492,-0.09641575,0.02744642,-0.053398483,-0.020556295,-0.050980967,-0.02091596,-0.07793135,-0.045934133,-0.00055911235,0.04968201,-0.03060046,0.02792433,0.047611114,-0.0053779124,0.0031562096,-0.001935931,-0.0035021387,-0.006822868,-0.0613685,0.019023512,0.009801111,0.02156808,-0.02204787,-0.02538485,0.0486248,-0.00035795692,-0.029370617,-0.025868915,-0.08827666,0.060357906,0.03291217,0.047620736,-0.01908058,-0.0040849955,0.040933367,0.0032613063,-0.07168261,0.017539952,0.012099452,-0.06417894,0.07936983,-0.06954231,-0.09431436,0.10878481,-0.022778878,0.04146491,0.06181368,-0.033921152,-0.043577522,-0.00439974,-0.079098746,0.069350295,0.012971522,0.024974545,-0.03445078,0.029185908,0.026736058,0.054122485,-0.03980176,-0.021312242,-0.015377758,0.091745645,-0.16109526,-0.07175728,-0.034677725,0.08669343,-0.070837714,-0.026379693,0.038995393,0.10155631,0.050128445,0.024731424,-0.06482558,-0.038780723,0.057551857,0.01736857,-0.027554018,-0.011408003,-0.025919704,-0.029090025,-0.08744305,-0.022014657,0.0043169395,-0.08683079,0.0007504093,0.0489909,-0.007240686,-0.029397203,0.0056629255,-0.0035308888,3.2324565e-06,-2.2359208e-33,0.07132818,-0.095985554,-0.06898777,-0.025435716,-2.0549021e-05,0.054261576,-0.035671078,-0.13809665,-0.052748054,-0.026478339,0.06075745,0.014991214,-0.06933507,-0.030976083,-0.006717503,-0.06991149,-0.02052752,0.09306384,0.06639445,0.09369845,-0.07776653,0.0048839315,0.00858587,-0.0013179948,0.052957516,0.019578237,-0.084908895,0.11270119,0.022055361,0.03267076,-0.05994346,-0.022777444,-0.048246246,-0.03856263,-0.020717569,0.06946244,-0.02774621,-0.0565063,0.024089495,0.05882057,-0.029601866,-0.05198813,0.058477547,0.046215195,0.10001609,0.06118402,0.030273693,-0.021244831,0.04164731,-0.035722267,0.051852025,0.007074894,0.036147602,0.019757245,0.009691841,0.09867083,0.07876443,0.011218245,0.03599214,-0.07889428,-0.004466507,-0.022926036,-0.021826088,-0.104464225,-0.02165696,-0.01301402,-0.009541728,0.13554133,-0.018068038,-0.058997877,0.09377397,0.05797684,0.057903204,-0.03186458,-0.050913855,-0.0067711454,-0.067887045,-0.04818615,-0.024069887,-0.12854575,-0.052729122,0.1031612,-0.04153831,-0.07650395,0.030872656,-0.099600576,0.06253255,-0.012354681,-0.017532635,0.012765442,-0.00905736,0.02248547,-0.0032923252,0.05458436,0.06716111,-2.8151963e-08,0.049182642,-0.018411472,-0.072295815,-0.045038655,0.023017434,0.0020086379,0.018023307,-0.019465877,0.015303386,-0.036491033,-0.07935381,0.090175115,0.017639898,0.012751619,0.043224078,0.037557308,-0.06165112,-0.058876403,-0.0688607,-0.07280195,-0.0872178,-0.009718688,-0.13541535,-0.03958746,-0.041016914,-0.111172065,0.07289166,0.020427436,0.014306147,0.007569643,0.020351775,0.046517536,0.05763266,0.07255611,-0.07989074,0.0297836,-0.0022232316,0.04674585,0.00800047,-0.05569324,-0.03512529,-0.024288872,-0.07835939,-0.0081935115,0.014537036,0.017647773,0.04819865,0.0022629604,-0.041458726,0.10488413,0.060957965,0.021558696,0.04460959,-0.0050972663,0.027019272,-0.02502844,0.016065497,-0.039206147,0.021807436,-0.056533366,-0.0929475,0.016448537,0.18275236,0.03936063 +4.2.3.67,"The recombinant enzyme from black peppermint (Mentha x piperita) gave a mixture of cis-muurola-3,5-diene (45%) and cis-muurola-4(14),5-diene (43%).",384,1.0,-0.05582228,-0.1121368,-0.12707755,0.035353757,0.072470196,0.063318275,-0.0065014428,0.08313174,0.026472783,-0.0966566,0.06935462,-0.049562942,0.0003812907,-0.033749774,-0.06465498,-0.009564908,-0.035716377,0.04271859,-0.033825666,-0.05927142,0.036731306,-0.041152865,0.070949785,-0.013790131,-0.0013300305,0.09434108,-0.0036206634,-0.027827507,0.047971684,-0.082876086,0.033755634,0.056145255,0.004080802,-0.10211693,-0.013438804,-0.028227244,-0.013054051,-0.092146285,0.11102584,0.009788985,0.047272902,0.054500062,-0.004221983,0.06251899,-0.012767918,-0.07179547,0.016218733,-0.01312482,0.012125659,-0.009181929,0.008975558,-0.032179017,-0.032014612,0.108955935,0.028026123,-0.027324816,-0.03938012,-0.0076354686,-0.015704248,0.077354245,0.014628186,0.04730165,0.009418598,-0.013207023,-0.020076597,0.0006532551,-0.10647115,-0.065774605,0.02497975,-0.02452172,-0.0056681363,-0.031388562,-0.040002204,0.034400888,-0.041175924,0.091560274,0.06412313,-0.055246647,-0.09095237,0.039467975,-0.020832548,0.08921205,0.019777933,0.118646994,0.045884717,0.038683724,-0.022535698,0.077553056,0.0015708882,0.026820483,0.011910952,0.019792289,-0.05526331,-0.06687156,-0.06309283,0.06597861,-0.027866546,-0.04138465,-0.020003991,0.013095853,-0.04130998,-0.012448722,-0.12085582,-0.15998816,-0.13415103,0.0036538835,-0.019573325,0.0430517,-0.019428167,-0.0045724693,-0.001979618,-0.0506118,-0.050812807,-0.01698136,-0.028283628,0.028932668,0.07050034,-0.013762237,-0.007844935,-0.013337625,-0.028366623,0.005267866,0.004255601,-0.0008866892,-0.01631282,0.003262051,-0.041665096,4.2974953e-34,-0.013259307,-0.04076706,-0.02789871,0.061820894,0.022695256,0.018002747,0.0012289069,0.06416106,-0.009548691,-0.04469261,-0.081457876,-0.073038176,-0.06865497,-0.048685577,-0.070354156,-0.0286954,0.021716647,-0.059498858,0.03314289,-0.0483023,0.011259789,0.09221776,-0.043978468,0.0140838185,-0.0018754578,0.06333357,0.0561833,0.010358561,0.12496302,-0.02227711,-0.074736334,-0.012967575,-0.033336014,0.013538353,0.029840656,0.086056605,-0.030159958,-0.011909996,-0.011580484,0.14035966,0.028410891,-0.0046989718,-0.019268584,-0.033776145,0.060945734,-0.01474833,-0.07811224,0.023092154,0.09928379,0.015370368,-0.007517206,0.0076714824,0.08335024,0.059392806,-0.05050184,0.029862914,-0.023009332,0.07929252,0.052083123,0.03786418,-0.06904053,-0.020624388,-0.0365929,-0.009035443,0.078871,0.0843151,-0.111967616,-0.027997814,0.012020014,0.08989105,-0.061705757,-0.034957364,-0.012008979,-0.029437449,0.08061799,-0.002356271,-0.091997154,0.07534908,0.10566773,0.037471473,-0.013343201,0.012784774,-0.0021756717,-0.002590218,-0.07366145,-0.011643545,-0.013158838,0.07522445,0.009553969,0.028005334,0.055461537,-0.07779357,0.00724291,0.038450554,-0.0586541,-1.0768968e-33,-0.050678514,-0.052169494,0.05528732,0.0079731895,-0.032323718,0.054645542,-0.05337245,-0.05563362,-0.008998618,0.07329944,0.07654065,-0.041155845,-0.014430402,-0.008521735,-0.04891754,0.013611329,0.015679553,0.1447752,-0.015139251,0.034829997,-0.03138073,0.09508897,0.0030878312,0.0039463,0.0028803553,0.05358403,0.104313694,0.07013006,0.10386382,0.031448785,0.039558984,-0.07152911,-0.048174623,-0.028362263,-0.019892372,-0.006733529,0.0086456295,0.048436675,0.010532866,0.028401269,-0.024701132,0.0081252605,0.04604011,0.12933046,0.04281896,0.052813612,-0.08773222,0.008313177,0.020273943,0.022110615,-0.004930976,-0.057814848,-0.060430538,-0.029523525,0.00284215,-0.057455186,-0.009418851,-0.030482046,0.037194278,-0.01257943,-0.04110819,-0.053541437,-0.037651964,0.019986678,0.037582833,0.036730368,0.03522798,-0.024253033,0.022712797,0.0115840435,0.08225881,-0.0028302963,0.038800158,0.0498027,0.01259955,-0.03261971,-0.023106415,-0.002572961,0.06628025,-0.035111647,-0.035598747,-0.05870015,-0.044468507,-0.061815932,8.1029706e-05,0.007352265,0.0327388,0.11423689,0.092542276,0.05441674,-0.021029837,0.073166505,-0.04369471,-0.0004805117,0.14195655,-3.737505e-08,0.020933332,-0.11109788,-0.055956468,0.044808432,-0.0055192993,-0.015787479,-0.06526536,-0.041670114,0.0934166,-0.0070016687,-0.0054711928,0.0319039,-0.019210849,-0.0022198085,-0.024699992,0.007684507,0.04638419,-0.013373306,0.045735534,0.024421724,-0.030622732,-0.056739025,0.011986206,-0.050514504,0.0044164406,-0.08485515,-0.035647128,0.05142554,-0.01177959,0.013099935,0.021856474,0.025851754,0.0031690444,-0.03301373,-0.029703634,0.007228178,0.016654463,-0.023134472,0.017702857,-0.050239395,0.018723505,-0.056989085,-0.042274136,0.012459544,-0.04406706,-0.040400833,-0.009057176,0.030242015,-0.0076237433,0.008547249,0.029352965,-0.016086735,0.022257598,-0.05405003,-0.10146805,-0.0074179475,0.029571384,-0.019738317,-0.056988448,-0.09289672,-0.032833003,0.0017174137,0.09024198,0.0027425871 +4.2.3.68,"The recombinant enzyme from ginger (Zingiber zerumbet) gives 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol (cf. EC 4.2.3.84, 10-epi-gamma-eudesmol synthase), 10% alpha-eudesmol (cf. EC 4.2.3.85, alpha-eudesmol synthase), and 5.6% aristolene.",384,0.99999994,-0.06962922,-0.040807735,-0.09122297,0.01824552,0.043561514,0.025085302,0.060978025,0.079251245,0.030200342,-0.022888787,-0.01941408,-0.025518538,-0.037393678,-0.0140371965,-0.10438529,0.001264206,-0.02068617,-0.0048965374,-0.03916543,-0.02963999,-0.031370383,-0.038689338,0.070134394,0.037853777,0.068464614,-0.0030758185,0.039321627,-0.06243332,-0.05404729,-0.090825066,0.012598554,-0.08511523,0.07278876,-0.07192562,-0.08377204,-0.021406665,-0.010356584,-0.14316423,0.038079847,0.030461442,0.04861154,0.036927085,-0.06618838,0.0045197853,0.006329844,0.029645683,-0.020356407,0.048797294,-0.00031190616,0.044607922,-0.06047062,-0.065409884,-0.02731185,0.04502842,-0.0035440032,0.05334788,-0.06444466,-0.05046708,-0.020067608,0.07016689,0.03791202,0.02857677,-0.08119599,-0.02124638,-0.100495435,0.019605046,0.012494508,-0.09348721,-0.06698756,-0.011734317,-0.09750292,-0.059433766,-0.045436755,0.042554095,0.011544724,0.049257867,0.049840666,-0.03370499,0.0032447746,-0.008867504,-0.014966413,0.03400899,0.027009983,0.045690645,0.074563876,0.03949976,0.04601891,0.08357712,0.09526394,0.06750333,0.06245459,0.034980323,-0.01964581,0.028640399,-0.03819191,0.06965482,-0.02496171,-0.008612965,0.06628614,-0.029475085,0.017541299,0.033298068,0.026965821,-0.06262741,-0.12742698,0.035157006,0.024086928,0.072028674,-0.014616155,0.040371444,0.034607798,-0.053494073,0.06715623,-0.058213938,-0.05773039,0.07802672,-0.0063649253,-0.047048423,-0.016956085,0.020898826,0.04425269,-0.003999433,0.04659424,0.07352759,0.018500073,0.034981325,-0.1183273,3.8540922e-33,0.0032323948,0.083098635,0.001172849,0.07334218,-0.019069558,0.12510313,-0.13831697,0.06843919,0.007754472,-0.093580544,-0.12257593,-0.046347305,-0.021726072,0.0030862004,-0.0018755986,0.038164515,0.026101816,0.01877613,-0.008386827,-0.009173762,0.012083308,0.04050402,-0.07864187,-0.022034558,0.015618461,0.023639113,-0.012042114,-0.023490433,0.007221532,-0.022640025,0.055312734,-0.059432507,-0.014111819,0.0457668,0.018726993,0.039236467,-0.024368713,-0.018162116,0.008757863,0.10277385,0.053522676,0.04624353,0.017478622,0.048982233,0.019731605,-0.055596985,-0.04400409,0.029817881,0.07733243,0.012867911,0.00017761167,0.012965975,0.063515484,0.12101032,-0.04110174,0.09920564,-0.09470855,0.05158192,0.105497666,0.044915188,-0.0746273,0.122156225,0.06666874,-0.016002383,0.051398724,0.032159764,-0.009307542,-0.03309436,-0.111046836,0.08086708,-0.0374613,-0.025048228,0.101773135,0.031241015,0.007889902,-0.06936064,-0.011659393,-0.018852675,0.045799114,-0.007648299,-0.06388166,0.0091636535,-0.00624996,0.0032472431,-0.024104739,-0.058153294,-0.031807333,0.0654884,-0.021239212,0.04413194,0.13040483,-0.07082031,-0.078169346,0.0023067053,-0.055152215,-2.3930703e-33,-0.0037998834,-0.10634571,0.019537631,-0.036590207,-0.013341486,-0.005710177,0.025975827,-0.040328924,0.04049048,-0.0025321972,0.07151295,0.0346327,0.03059812,0.0058124657,-0.03269689,0.0041627754,0.01884524,0.105033144,-0.0023989663,0.0064428244,-0.054424576,0.043701965,0.05241807,0.039293658,0.024106918,-0.010160096,0.05566236,0.058743175,0.06833296,-0.037136007,0.011951785,-0.024381133,-0.019333497,-0.13808487,-0.053866632,0.025461689,-0.0053516882,-0.008289887,-0.013646777,-0.008193184,0.029421108,-0.02749315,-0.017751772,-0.004740778,0.10235519,0.08789082,-0.02750213,0.029371323,0.019209791,0.02054183,0.08194837,0.0066150483,-0.019841487,0.029056748,0.015955582,-0.043279123,0.011284686,-0.008793523,-0.0035573381,0.047156677,-0.010370879,-0.0015616287,0.079186626,-0.019815592,0.027095059,0.00819094,0.036645107,0.13697915,-0.0006512308,0.03676376,0.07600943,-0.020711627,-0.03337809,0.06093072,-0.0105718095,-0.012889763,-0.0193136,-0.019583212,0.040936448,-0.04161066,0.001533271,-0.042922236,-0.0021294667,-0.027400479,-0.037337348,-0.035823863,0.02122031,0.048169836,0.030782046,0.0026575841,-0.051910296,0.0037164872,-0.0058999346,0.036070373,0.06810443,-4.3400725e-08,0.082391344,-0.079041585,0.021527719,-0.040218826,0.0042280043,0.030356899,0.024563022,-0.014323437,-0.05816022,-0.02390922,-0.0071038264,0.09920929,-0.047681462,0.018903255,-0.014972499,-0.0033963856,0.007069845,0.0780352,0.0042830855,0.038048476,0.007917989,0.068756066,-0.057447005,-0.06289926,-0.01979589,-0.08074082,0.074775815,0.033598665,-0.028912276,-0.08384772,0.028524656,0.010974366,0.054034565,-0.055764887,-0.08885117,0.007688724,-0.031903405,0.020280892,-0.0022330126,-0.018592725,-0.03825342,-0.09806038,0.00961699,-0.044955842,-0.09849103,-0.012469077,-0.0005685087,-0.060055666,0.0769376,-0.040191103,-0.0048451573,-0.0058983983,-0.014228948,-0.10220425,-0.08244629,-0.014722663,0.012567627,-0.04668079,0.011515736,-0.07799856,-0.0037747812,-0.04247953,0.07335534,0.02417945 +4.2.3.69,"The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% alpha-barbatene, 17.8% thujopsene (cf. EC 4.2.3.79, thujopsene synthase) and 9.9% beta-chamigrene (cf. EC 4.2.3.78, beta-chamigrene synthase) [1] plus traces of other sesquiterpenoids [2]. ",384,0.99999994,-0.027676772,-0.09324399,-0.09978963,0.016841142,0.010478332,0.03724863,-0.022915555,0.098881535,0.08341604,0.032998305,0.02366502,-0.05821467,-0.038844213,-0.11052514,-0.044259883,0.026788097,0.007913455,0.04856423,-0.0058529694,-0.08438605,-0.023408525,0.0038704867,0.0011360574,0.03189118,0.105234906,-0.03879207,-0.018534478,-0.05217556,-0.005229615,-0.09882085,-0.06923068,-0.008630615,0.070682816,-0.035607174,-0.046693165,0.05589921,-0.009570587,-0.11163223,0.10271063,0.018034382,0.09698257,0.021878647,-0.02760656,-0.022416012,-0.039013598,0.0049840165,-0.02678063,0.07629184,0.03939747,0.040608305,0.00071256526,-0.044390865,-0.033453807,0.02479751,-0.03321313,-0.06642597,0.049403053,-0.021215804,0.012507417,0.1368492,0.029054742,0.013115542,0.013972954,-0.047383126,-0.0125132175,-0.043327,-0.057402276,0.033259764,0.06055136,-0.05254291,-0.04739211,-0.0036712887,-0.037687343,-0.007933268,-0.04609839,0.053605996,0.028571796,0.072455175,-0.0014828967,-0.042560305,0.07314031,0.0038449632,0.05664494,0.055547636,0.029190544,0.026999593,-0.021799259,0.068342894,0.06869406,0.08109977,0.043120533,0.067421004,-0.021693835,-0.08713312,-0.046092745,0.09058618,0.02025438,-0.037014645,-0.022374643,-0.028924081,-0.0061235535,0.049687028,-0.029254116,-0.12969072,-0.06452705,0.055011444,-0.00062806776,-0.029179404,0.027145805,-0.004126798,0.009497066,-0.001921135,0.008009075,0.015495057,-0.0044399733,0.037286665,0.024669202,-0.034623463,-0.0013906086,-0.026665652,-0.0369411,0.02356053,0.03696079,0.027059775,-0.07393012,-0.029230246,-0.07630954,3.533881e-33,0.048138928,0.12265558,-0.050849237,0.013251108,-0.007270298,-0.015923366,-0.07899808,0.11999739,-0.06746937,-0.073933356,-0.10435767,-0.115409695,0.007489622,0.0070952117,0.050967816,-0.040999677,0.0061477134,-0.011861091,0.070635915,-0.067270294,-0.07277359,-0.016270496,-0.081683815,0.030152477,0.011617015,-0.026172455,0.05050676,0.031177206,-0.0029900891,-0.056772817,-0.019513398,-0.007621492,0.03905779,-0.045673523,0.020947766,-0.036100652,-0.041198984,0.0016638974,-0.09360926,0.06658026,0.024979638,0.07205549,-0.009091775,-0.033344395,0.013406917,-0.05324757,0.005124112,-0.03110805,0.13923226,0.014886535,-0.041656118,0.066688836,0.14792821,-0.020635052,-0.03735138,0.015699217,-0.03210605,-0.0033154911,0.05750252,0.052144725,-0.004240498,0.07338348,-0.05288102,-0.0317257,-0.08351538,0.11390284,-0.09397557,-0.025770694,-0.02745546,0.06701386,-0.015681623,-0.0633006,-8.880039e-05,-0.06672321,0.06886356,0.012241713,-0.08804248,0.001986286,0.037573677,-0.04215293,-0.021902481,-0.00939918,-0.032704912,0.0062260977,-0.019997494,-0.06815044,0.03016619,0.03929007,0.0077003706,0.032831583,0.103115484,-0.09047539,-0.0073395497,0.021134987,0.035011858,-2.5630457e-33,-0.0044343164,-0.06097993,0.01912723,-0.051823594,-0.028450184,0.06251636,-0.023565091,-0.061647717,-0.038117994,0.03960545,0.04018021,-0.0052909628,0.038993027,-0.06679692,0.009240168,-0.009864331,0.04009259,0.06710507,1.7833429e-05,-0.043719236,0.032956667,0.04433875,0.11923999,0.035474174,0.0046463907,0.015014506,0.053929225,0.08272018,0.046242036,0.00073364296,0.026674753,-0.046720296,-0.00036555616,0.0012274653,-0.098948754,0.0016373061,-0.026443193,0.0075476132,0.044919018,0.046323225,0.0320292,0.004736706,-0.025276205,0.09881683,0.07716571,0.025929581,-0.06457135,-0.002692955,0.02339756,-0.02791798,0.07828642,0.024125343,-0.047129676,0.044789366,-0.004769923,-0.0041346466,-0.016633296,0.067657925,0.00044545537,-0.047616556,-0.03195021,-0.06868993,-0.012919926,-0.02091922,0.07654617,0.043098573,0.004803531,0.09636716,0.020530367,0.034338508,0.087036766,0.05052816,0.0010305061,0.050476037,0.0074412874,-0.039083138,0.03925345,-0.09625266,-0.042379964,-0.029033218,-0.013340311,0.030126942,-0.025997754,-0.042482063,-0.04839351,-0.066678606,0.045157477,0.08540448,0.012343038,0.08880214,-0.011130565,-0.00048086455,-0.060896795,0.07258002,0.13319382,-4.7354842e-08,0.007035157,-0.05356726,0.0017837923,0.011494279,-0.016596822,0.028380897,0.0011559017,0.016011799,-0.0187228,-0.01102362,-0.03637997,0.052084878,-0.020742586,0.05101717,0.06210799,-0.047575254,0.046794705,0.071329184,0.008051756,0.020014396,0.033341102,0.03544717,-0.06287878,-0.011587035,-0.037889604,-0.086571135,-0.03982478,-0.021067105,0.01237243,-0.024432361,0.059217658,0.011680622,0.012906247,-0.087440886,-0.05829267,-0.0042112647,-0.022640267,-0.046462726,-0.002726628,-0.0033727214,0.0067767366,-0.032993924,-0.07410463,0.03427062,-0.052252598,-0.018510472,0.04204179,-0.00087986584,0.051875986,0.025054246,0.0399774,-0.026934037,0.02566357,-0.09783663,-0.055925075,-0.031894367,-0.050174735,-0.039419614,-0.023042925,-0.051853433,0.057057258,-0.030462291,0.18365975,-0.03163875 +4.2.3.72,Initial cyclization probably gives biyclogermacrene in an enzyme bound form which is not released to the medium. The enzyme from Solidago canadensis also forms a small amount of (+)-gamma-gurjunene [1].,384,0.99999994,-0.08729619,-0.04428183,-0.05389603,-0.02465482,-0.031462405,-0.016551618,0.05450216,0.07148588,0.015192528,-0.00959688,0.085216545,0.012291582,0.010116872,0.08240684,-0.03868043,-0.0017752793,-0.025726924,-0.028983189,0.040803608,-0.01744284,0.05252872,-0.031541258,-0.031680416,0.018084988,0.068578064,-0.07466491,-0.0009567331,-0.03507523,0.038228557,-0.045326144,-0.016516086,0.05386413,-0.04721713,0.0025235342,0.03572878,0.050622504,-0.07292598,0.011212759,0.04375844,-0.01818727,0.047750577,0.028760754,0.008262386,0.0106745185,-0.041134536,-0.06719911,0.019324169,0.009408615,-0.021604246,-0.057095405,-0.024436975,-0.038409334,-0.05669488,0.034020104,0.030874118,-0.00887021,-0.12294452,-0.009994485,0.018642548,-0.023306338,-0.018412806,0.038747374,0.023429234,-0.051133074,0.019611584,-0.052374676,-0.006078267,-0.029196652,-0.00033560622,0.021348298,0.03744235,-0.015343415,-0.069660306,0.0026396473,0.00823406,0.019426288,-0.01498773,0.029919324,-0.033305675,0.009783686,-0.021327004,0.0027334252,0.0010678322,0.08094558,0.039089423,0.029577797,0.047309805,0.024213111,-0.00053382653,0.0020357845,0.092716195,0.06375895,-0.0380998,-0.04812155,-0.048604097,-0.009767142,0.037344724,-0.015531655,0.062514015,-0.01345415,0.13046864,-0.028540786,0.052755833,-0.042575452,-0.056116223,0.028510422,0.05468201,0.011516051,0.050432604,0.057392977,-0.0064941566,0.05082619,0.06838206,-0.0014961202,-0.11428851,0.17094433,-0.00046538727,-0.011256558,-0.046249285,0.0024085501,-0.021321844,0.039121874,-0.052564465,0.09502899,-0.04183686,0.13164663,-0.07385898,3.4253692e-33,0.024825891,0.03246676,0.08957191,0.043763325,-0.040866192,-0.021127036,-0.02891812,-0.034381337,-0.10841649,-0.0535433,-0.11510143,-0.013133128,0.0077944207,0.015833847,-0.016244223,-0.009106941,-0.06281274,0.0061356896,0.027512882,-0.0026343772,-0.03935889,0.014542937,-0.08492538,0.04420146,-0.016474536,0.030117687,-0.0076423343,0.024837699,0.008056069,-0.008087099,0.003778564,-0.03170626,-0.11909623,0.031990997,0.05159499,-0.015910616,-0.0058140983,-0.014941708,-0.008626031,0.031462967,0.018791297,0.026505759,-0.027955413,-0.006514219,0.08379621,-0.06050316,-0.052975077,0.11059895,0.013763446,0.06001345,0.013649616,0.01572566,0.015374878,0.017554116,-0.052980904,0.13137503,0.051042207,-0.008838135,-0.015235947,0.0043303794,0.0066090603,0.049576223,-0.019892208,-0.052794687,-0.04398602,0.06619782,-0.063539945,-0.014030959,-0.066926606,0.024824968,-0.06717206,-0.025902264,0.032776393,0.025119808,0.10642822,-0.0024360043,-0.06663175,-0.038647365,0.06522713,-0.010228191,-0.061016332,-0.0047130412,-0.03868615,-0.044629928,-0.11626657,-0.020852372,0.015548517,-0.044828184,-0.019044578,0.12990426,0.064960346,-0.06460213,-0.04613145,0.032351885,-0.07584166,-4.114201e-33,-0.010862112,-0.10474161,0.016849302,-0.06482138,-0.0050528436,0.014565942,-0.035822943,-0.08907825,-0.010353282,-0.06109044,0.061106015,0.054479916,0.010550649,-0.026030554,0.010351789,-0.029220307,-0.018688148,0.1786171,-0.020802777,0.032256626,-0.07411753,-3.3727934e-05,0.018755205,-0.027138818,-0.057473596,0.083021894,-0.010738658,0.08233267,0.07231314,0.0381402,-0.01880237,0.00053238333,-0.08550607,-0.042526416,-0.029974116,-0.010879916,-0.036936276,-0.04284029,0.031400494,0.040027443,-0.083767325,0.024694229,0.043182865,0.086636886,0.103083506,0.05870581,0.061598193,-0.058780983,-0.026855737,0.011931944,0.050854314,0.01847277,0.022798965,0.0351877,0.003475272,0.059467148,0.027575085,0.0456176,0.0029409265,-0.07457159,0.0012239835,-0.020305702,-0.0010879288,-0.069369934,0.031596582,0.025747744,-0.0049048704,0.11576117,-0.030059718,-0.054298334,0.056053665,0.009513635,0.0053562364,-0.013720459,0.019436015,0.053347822,-0.05287307,-0.07331716,-0.027656877,-0.12503812,-0.0385948,0.046667,-0.035359554,-0.10912992,0.048280656,-0.105825536,0.033314712,0.038741656,0.043964535,0.03234737,-0.046390086,0.0051249587,-0.014815816,0.06952306,0.09341605,-3.971258e-08,0.0068643326,0.0074530044,-0.0905947,-0.021961732,-0.030177351,-0.02093191,0.012096726,0.01540385,0.022594003,0.024368452,-0.029479535,0.093984164,-0.001567524,-0.008653707,0.059402384,0.022099027,-0.0056901206,-0.044710822,-0.0414967,-0.059466578,-0.10341461,-0.009894063,-0.09312642,-0.017448457,-0.07832299,-0.06674377,0.08982347,0.05549044,-0.0010718766,0.006206061,-0.0047533982,0.0725424,0.000121794474,0.033776943,-0.04573226,-0.006482877,-0.058805645,0.04993001,0.11168979,-0.017619614,-0.008736172,-0.042217344,-0.088811696,0.013504037,0.023492644,0.042247627,-0.018640198,0.063013636,0.009475063,0.07529186,0.0060357135,-0.041371305,-0.0019354607,-0.089135066,-0.051315743,-0.007379467,0.021817707,0.03827032,0.0340362,-0.067914166,-0.11095504,-0.008318996,0.13877684,-0.016776418 +4.2.3.73,The recombinant enzyme from Vitis vinifera gave 49.5% (+)-valencene and 35.5% (-)-7-epi-alpha-selinene. Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.,384,0.99999994,-0.023246486,0.029273774,-0.124251395,-0.017504377,-0.005044659,0.036676392,-0.018788828,0.11840181,0.02972199,-0.019251827,0.038175013,-0.005454723,-0.038906366,0.032920532,-0.09015245,-0.031308718,-0.0060408805,0.040718906,-0.04138117,-0.0220684,0.030995348,-0.009078859,-0.007111926,0.027133187,0.10812836,-0.029487247,-0.0069525,0.010495899,0.022342443,-0.03245043,-0.045435864,0.038526256,0.040522926,-0.068688005,-0.003658295,0.019863945,-0.017292537,-0.06905002,0.031739473,0.04239816,0.016759388,0.023389492,-0.083437756,0.05717543,-0.0076092477,-0.039619323,0.019650292,0.04422647,0.05212568,0.06731113,-0.019001108,-0.035380952,-0.095091105,0.02585288,-0.031674366,-0.014840881,-0.04355664,-0.018666716,0.019605419,0.013557831,0.055766154,0.027297843,0.01110939,-0.0074885106,-0.0056751873,-0.07987275,-0.0008362901,-0.021881696,-0.04601212,-0.023418382,-0.029308746,-0.025158215,-0.013409189,-0.020753462,-0.014381137,0.06600697,-0.008339386,0.043739602,0.025703281,0.016089937,-0.0007999362,0.014143966,-0.018471472,0.08197741,0.0315927,0.057095475,0.054991245,0.035499632,0.04780336,0.054007404,0.01678161,0.01070745,-0.014205783,-0.088819325,0.05101813,0.023806863,-0.008841276,-0.07799779,0.017410845,-0.0009632013,-0.03180925,0.029858608,-0.05487193,-0.044432223,-0.10909389,0.06242582,-0.04497883,0.11663702,-0.005760651,0.012400784,-0.019173067,0.03559829,0.082971275,-0.023875445,-0.0006356314,0.18038028,0.038357534,-0.018096773,0.025102828,-0.028314352,0.019938534,0.011630971,0.07844603,0.09883106,-0.03947966,-0.0028715606,-0.01234085,2.5429883e-33,0.0025236274,0.02505706,0.028697979,0.05941113,-0.05571058,0.03610544,-0.09520097,0.04462697,-0.09111524,-0.0674743,-0.1677337,-0.06975113,0.10229372,0.032474592,-0.019914666,0.003274313,0.054145217,-0.04738081,-0.064199015,-0.029746909,0.020021839,0.011335766,0.007045339,0.034597535,-0.016347794,-0.027242826,0.018540367,0.006853146,0.002890881,-0.038507294,-0.026665809,-0.055909734,-0.029348368,-0.028973475,0.033042468,0.033929214,-0.017084127,-0.026392188,0.011932408,0.08409593,-0.022145241,0.081207715,0.035065465,-0.06302704,0.04390691,-0.09219213,-0.07693733,0.047632374,-0.009474245,0.040882733,-0.015114183,0.059497945,-0.0050782505,0.02068141,-0.114832215,0.06902127,0.04164554,0.046264723,-0.0043498166,0.020711955,0.033818502,0.07861553,0.02421881,-0.049605593,-0.0356672,0.08638776,-0.116787344,-0.038050342,-0.06701614,0.118813835,-0.0717054,-0.003909464,0.004049666,-0.054594778,0.04397797,-0.03215214,-0.08912475,-0.07069376,0.032637153,-0.0012210589,-0.11991128,-0.002800764,-0.007412678,-0.055242095,-0.038710013,-0.10454803,-0.03978312,-0.03747885,-0.0034322902,0.08498585,0.056161124,-0.05470753,0.0008972946,-0.005082931,0.041349262,-2.8480272e-33,0.007939024,-0.07419324,0.010856533,-0.039705355,-0.045345288,0.05846948,-0.025083933,-0.09400226,-0.06648991,-0.032537743,0.06290173,0.024520611,-0.0074723996,0.0022894044,-0.037103366,0.02226959,0.02171595,0.0879239,0.043797586,-0.010314262,-0.024073327,0.015932066,0.046210486,0.022578042,0.0767874,-0.018404797,-0.011539108,0.07400507,0.010847465,0.00043140652,-0.018002186,-0.049181517,-0.07197063,-0.0015911484,0.011442874,0.057227734,0.0115782125,-0.013019393,0.064554155,0.03972913,0.023238542,-0.03088489,-0.010506377,0.08469085,0.034685627,0.056311153,-0.049135648,0.058100715,0.07404408,-0.017659698,0.09858659,0.017462034,0.045264274,0.071849994,0.030188143,0.0689116,0.052088518,0.013224265,0.033784624,-0.00038219136,0.042174403,-0.040753163,-0.02578965,-0.10416212,0.023038313,-0.00014334799,0.009260826,0.12043098,0.015706044,-0.086607225,0.1120582,0.04937714,0.010985201,0.0705005,5.1401606e-05,-0.082994886,0.010031554,-0.069309115,0.019996027,-0.08225038,-0.057402823,0.01585405,-0.046693463,-0.07617017,0.0070874947,-0.02554114,0.0313594,0.03407674,0.051613394,0.03425212,-0.028318826,0.0085614985,-0.03837649,0.008375225,0.097272664,-4.1385825e-08,0.04613704,-0.07234553,-0.04601671,-0.060828585,-0.018879846,0.01227218,-0.0040112613,0.029494442,0.007696388,-0.05551467,-0.0060151336,0.073928,-0.03897254,0.014071649,0.042778987,0.038728476,-0.013325773,0.033686295,-0.02467312,-0.01885877,0.0015154219,0.003475511,-0.117296346,-0.038453817,-0.033983354,-0.1277391,0.01776012,0.024412114,-0.0066632144,-0.04754093,0.036163922,0.020412974,0.013595472,-0.038511578,-0.09673608,0.06115961,-0.0039289882,0.06473848,-0.011464641,-0.021564065,0.013431431,-0.06389166,-0.051629145,-0.036889415,-0.023495708,-0.005390374,0.078969434,0.014276217,0.002657006,-0.0006189327,0.070020095,0.045304313,0.07615804,-0.011622596,-0.09045946,-0.019729624,0.003822013,-0.08688775,0.036344327,-0.085554235,-0.049989734,-0.06146375,0.18684712,-0.032535087 +6.4.1.8,"The enzyme is involved in anaerobic degradation of ethylbenzene. No activity with acetone, butanone, 4-hydroxy-acetophenone or 4-amino-acetophenone. ",384,0.99999994,-0.029018631,0.028488096,-0.016893536,-0.016234735,0.106707014,0.05345133,-0.04360076,0.042713832,-0.043475393,-0.0029218036,-0.03469836,-0.050865095,-0.056256585,0.05294682,-0.08577345,0.118425295,-0.018886315,-0.000101450154,-0.033853807,-0.022305734,0.024568178,-0.048214506,0.025485402,-0.0040557496,0.06644537,-0.018645952,-0.0033994548,-0.0103011485,-0.024861518,-0.07279681,0.019685049,0.005234276,0.061747618,0.045452703,0.04452154,0.07715353,-0.00030023238,-0.048843108,0.013110555,0.0037252465,0.031062007,0.041848995,-0.08550872,-0.0460389,0.03520773,-0.035174824,-0.050282016,-0.04834907,-0.0061759795,-0.048449494,0.044944454,-0.016466036,-0.008763996,-0.038340457,-0.009805216,-0.06440062,0.020671548,-0.045348257,-0.093576916,0.07077767,0.0952104,-0.04479617,-0.06070652,2.281091e-06,-0.021803442,-0.05516645,0.085305475,-0.026919473,0.03368254,0.044527054,-0.03250114,-0.11916915,-0.04340172,0.01839595,0.011421583,-0.042556137,0.06557843,-0.058073938,-0.010787224,-0.106891684,-0.010882472,-0.0020158002,0.040774588,-0.017677011,0.10440708,0.06495421,-0.037309647,-0.031169964,0.07060324,0.07751999,-0.043840963,0.042319734,-0.0075411755,-0.04837204,-0.004351335,0.036000688,0.04735749,0.013928336,0.0013417256,0.039622456,0.044714354,0.13471234,-0.09872587,-0.11878341,0.031903002,0.009740025,0.12584485,0.019941308,0.011509313,0.009419234,-0.020039758,-0.028678892,0.02598322,0.04579137,-0.03524955,0.06582648,0.043553803,0.0027820717,-0.040629506,0.06390677,-0.045462687,-0.02291188,0.005385666,0.043764237,-0.023044305,-0.002116635,0.012213488,1.1864878e-33,0.0022154644,0.0034605414,-0.05284607,-0.024659194,0.048983518,0.008195575,-0.03899417,0.054842435,0.032293357,-0.0754268,-0.021155873,-0.03384662,0.018573793,-0.0044196355,0.013478593,-0.008251632,-0.0029944745,0.017298548,0.020524388,-0.033883385,-0.039024446,-0.04014856,-0.08534849,0.02427617,0.02869492,-0.016777175,-0.0048955814,0.057392,-0.005429528,-0.024630263,-0.029668767,-0.017577793,-0.10130569,-0.0006272491,-0.004003781,0.08110134,-0.010508467,0.05657631,0.010830574,0.08237711,0.008515972,0.053887352,-0.034792103,-0.020947335,-0.038715098,-0.016280163,-0.04512251,0.110294946,0.05827007,0.0040490464,-0.0009814136,-0.0586463,0.12328161,-0.045437798,-0.0018553836,0.093928814,0.01503319,-0.009252958,0.048180774,-0.021387598,0.027934179,-0.015522887,-0.060547538,0.037928037,0.031220729,-0.0020143124,-0.07288654,0.019159451,-0.018179333,-0.025477204,-0.0943124,-0.056225657,0.088203266,0.032520223,0.01907705,-0.023613302,-0.108993135,-0.04215172,-0.006894196,-0.011915406,0.036202557,-0.060413644,-0.00962976,-0.10299442,-0.052136224,0.03737397,0.057323914,0.0101953,0.06481784,0.020275718,0.0853657,-0.06412006,-0.022172244,0.018152433,0.025336761,-1.797398e-33,0.06854834,0.021812657,0.0005695698,-0.051307667,-0.023710337,0.056370847,0.009827967,0.00089028483,-0.025329031,0.006053094,0.082856275,-0.0917261,0.021700183,-0.027025744,0.036009118,0.053280286,-0.04782447,0.02562122,-0.019956825,0.014931112,-0.10777443,0.056349106,-0.020162255,0.05666466,0.0084969895,0.05534671,-0.05995792,0.04403266,0.07234491,0.015409537,-0.04047831,-0.04197065,0.0073485025,0.01244315,0.0063897925,0.10898556,-0.011560033,0.008889035,-0.07026112,0.030407876,0.022311179,0.04684265,-0.03895529,0.047403708,0.070025355,0.073910564,-0.0995013,-0.011916481,-0.08597397,-0.082041316,0.104689196,-0.010673153,-0.053958952,0.030935315,0.030886186,0.07026798,-0.0050234315,-0.035127927,-0.0697245,-0.014134286,-0.012410004,0.010505601,0.0047108694,0.041257385,0.030311527,0.037005182,-0.07404519,0.12135116,-0.029610777,0.015615172,0.055754706,0.058957558,0.012807036,0.048154008,-0.07977568,-0.040455356,-0.022359258,-0.08425413,-0.10723006,-0.1147605,0.0008726717,-0.004149393,-0.03607783,-0.03630649,-0.116304465,-0.032364443,-0.01949865,0.060952026,-0.02906773,0.0052668867,0.042368766,-0.008640494,-0.074717835,0.09656663,0.036663264,-2.927274e-08,0.06324312,-0.023415126,0.11548795,-0.016892891,-0.024566034,-0.075171255,0.10065769,0.033993393,0.091108754,-0.013577666,-0.11516489,0.063372314,0.030369978,0.007027141,0.018293107,0.0059583276,-0.0037032978,0.048507847,0.009421067,-0.013520754,-0.07916431,0.011466732,-0.079571836,0.03680217,-0.0037337379,0.008136003,0.045555737,0.12980945,0.027609607,-0.04346835,-0.01533988,0.046265405,0.043475296,0.02150086,-0.029806735,0.026266264,0.040882144,-0.09054089,-0.031538565,0.01330675,-0.028326256,-0.009410676,-0.093825586,-0.018214047,0.07291354,-0.014097277,0.05756128,-0.016795183,0.023811337,-0.04633598,0.035467394,-0.0012621019,-0.032371998,-0.0142508475,-0.07246841,0.018623268,-0.048017178,0.015483644,-0.027282417,-0.0629257,0.019387806,-0.044055622,0.15948911,-0.059619397 +1.1.1.312,"The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].",384,1.0,-0.0020358365,-0.03449717,-0.07314472,-0.026964612,0.0057966853,0.0073293983,-0.058046453,0.020106219,0.03245263,-0.021686347,-0.047549974,0.056720655,-0.068135045,0.036560263,-0.027059255,0.0820151,0.0027512829,-0.040726718,0.031357534,-0.008679709,0.025933193,-0.023473335,0.025649521,0.032030497,0.023801366,-0.004172163,0.06355484,0.07420934,-0.024984289,-0.052824706,-0.023320554,0.00706787,-0.024382375,-0.04709047,-0.032234844,0.012469518,-0.044117063,-0.07733703,0.03047657,-0.021627963,0.059038635,-0.026826482,-0.090122804,0.0397343,-0.02296882,-0.07771416,0.059976704,0.03819502,0.022341924,0.034683134,-0.039621577,-0.039327223,-0.018181667,0.043002892,-0.015912438,-0.030531958,-0.04850363,0.036917537,-0.033847123,-0.017182963,0.04298552,0.018009504,-0.004759373,0.012969199,-0.030800873,-0.049712118,-0.01833833,-0.03239279,-0.019367393,-0.062246125,-0.1269532,-0.08898341,-0.014444021,0.029577997,0.00934398,-0.029055022,-0.016709013,-0.06553189,0.062816694,0.030344283,0.021933818,0.06630865,0.04240286,0.07580857,0.031469185,0.053772483,0.018505113,0.07150511,-0.018328097,-0.09792817,0.024833543,0.010272692,-0.049324553,-0.008370906,-0.076336436,0.0389556,-0.024901954,0.07993535,0.024646971,0.00760591,0.054599974,0.038541738,-0.04148586,-0.08656657,-0.068203434,0.03669976,-0.015782157,0.10949872,0.0021087057,-0.0006740315,-0.056641147,-0.016782025,0.018997498,0.00092948537,-0.06490052,0.1551926,-0.03386977,-0.037885636,-0.06386212,-0.020094695,0.03628694,-0.015341577,0.10357907,0.035136927,-0.02908671,0.0513603,-0.08467434,6.780902e-34,0.02897488,-0.029851027,0.045423597,0.0059405006,0.0930447,0.02648016,-0.09607747,0.017388253,-0.09416544,0.0040130345,-0.017994877,-0.09769766,0.036758143,0.008242326,-0.009753308,-0.028595721,-0.00624843,-0.02503001,0.051658668,0.040291566,0.041368928,0.10170824,-0.053271413,0.08115303,-0.009485484,0.10714365,-0.042603657,0.09965332,0.0643991,0.005067186,0.03821141,-0.08824856,-0.11262303,-0.0674597,0.03768038,0.00015956555,-0.08496733,-0.005751462,-0.022921737,0.04472004,0.02157088,0.010658319,0.054344777,-0.05322436,0.06530181,-0.09059425,-0.015394462,0.07666081,0.034597125,0.01000662,0.02823119,-0.055313326,0.08585416,0.0027379885,-0.04450793,0.090504296,-0.075060025,0.015874524,0.08305422,0.0033411938,0.026856264,-0.014609335,-0.08391981,0.04331042,-0.028248178,0.036092244,-0.08535805,-0.015111914,-0.007818544,0.08618051,0.02216357,0.028390305,-0.03940145,0.027412353,0.08247451,-0.047477875,-0.05341229,-0.008414317,0.06666661,0.0030202817,-0.03475618,-0.0066922354,0.025941242,-0.026753198,-0.048309755,-0.029940095,-0.029899279,0.028807813,-0.01090066,0.09604086,0.018403308,-0.0603405,-0.088381,-0.007889911,0.046647437,-2.532935e-33,0.08051814,-0.084108956,0.045035493,-0.08912036,0.01869286,0.05079577,0.05946679,-0.091091745,-0.027374294,-0.0014906315,0.10561469,0.026981674,-0.049779497,0.012700305,0.06732526,0.037586853,-0.037726566,0.003131433,-0.010365529,-0.0033542162,0.04649676,0.06892845,0.00083379983,-0.023835124,0.014011145,-0.05143845,0.07961924,0.03476825,0.122899525,0.07267678,-0.049297635,-0.03509185,-0.042380266,-0.030407913,0.0076774415,0.04188082,-0.07680657,0.0062096715,-0.052105684,0.048339467,0.013197979,0.0046540787,-0.034235228,0.071149506,0.07142769,0.0799628,-0.13544007,0.038653333,0.011450771,-0.0917544,0.025712559,0.029041292,0.0013506123,0.032337826,0.06437896,0.026935937,-0.014682751,-0.017992523,0.054991994,-0.010638402,-0.057702795,-0.04867122,-0.03195733,-0.03962048,0.08264988,0.023141354,-0.04932763,0.0074715586,0.035967257,-0.04853826,0.10713193,-0.0076151355,-0.04876251,0.0053750104,-0.043300077,-0.019245196,-0.06948571,-0.004345786,0.0011121293,0.005602058,-0.0015060348,-0.049503423,0.006977479,-0.066772945,-0.0043066996,-0.0487835,0.020077294,0.081322215,-0.027148865,0.05985615,0.014857005,0.018939355,-0.041961774,0.0066086925,0.027565658,-4.9577146e-08,-0.044164717,-0.10183578,0.054490026,-0.070493326,-0.027467547,0.015537995,0.020446407,-0.034916468,0.031545587,-0.0047414373,-0.008144703,0.06251613,0.0314594,0.031734053,0.024933135,-0.008235754,0.035615403,0.036546987,-0.009338348,0.0038554354,-0.06318097,0.035213083,-0.12225438,0.029563567,-0.0064209537,-0.06168943,-0.040627405,-0.023313805,0.01463169,-0.00812321,0.02250768,0.07102276,0.078283384,-0.037726082,-0.117018305,-0.00071941287,-0.07377289,0.023332901,-0.048735894,-0.012916159,0.086256586,-0.14057225,-0.006074421,-0.032119196,0.015356897,0.032293998,0.023564138,-0.038065977,-0.04164365,0.005327814,0.081176825,-0.0035937137,0.008832459,-0.009087287,-0.04868606,-0.019060869,0.012633878,-0.0783912,0.0012622741,-0.07261303,0.024325198,0.0041281967,0.19037017,-0.025657238 +1.1.1.313,"Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyse this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells. cf. EC 1.1.1.433, sulfoacetaldehyde reductase (NADH).",384,1.0,-0.0035955955,-0.046116665,-0.03978865,-0.014220127,0.056260172,0.06517082,-0.032546863,0.07560662,0.044460278,-0.004833068,-0.055319764,0.015008204,-0.030937036,0.010666669,-0.020682907,0.05940127,-0.059928976,0.0057210852,0.05081618,-0.055046305,-0.00885425,-0.029531347,-0.016764287,-0.03093035,0.055653844,0.031297024,0.0010209961,-0.048135716,-0.04355871,-0.049781002,0.0010093187,-0.028675102,0.012271682,-0.055196587,0.056892645,0.01634292,-0.025087107,-0.027975777,0.023585299,-0.008189959,0.043342926,0.07821059,-0.06385587,-0.018784042,-0.02122258,-0.022420557,0.012952938,0.054763094,0.0291486,-0.011691736,-0.03623316,0.04864147,-0.06278641,0.05422251,0.07514383,0.08834517,-0.034078848,-0.13020673,0.018156573,-0.030401727,0.040367197,-0.04909217,-0.048557475,-0.03585047,0.082022496,-0.04688467,0.04530782,0.005049607,0.05243345,-0.008761017,-0.062102757,-0.005640195,-0.009464636,-0.0036936235,0.018852727,0.012878908,-0.05551656,-0.04526596,0.047827374,-0.06035627,0.0074501703,-0.02755878,0.0584314,0.020973079,0.12537317,-0.017942835,-0.0036105167,-0.054943576,0.07983872,0.021034703,-0.011092295,0.060058378,-0.029320953,-0.048410486,-0.036576632,0.045189124,0.064004645,0.065615125,0.02521579,-0.008850367,-0.017247476,0.03501908,-0.035781696,-0.09641017,-0.028755121,-0.0008320501,-0.058916062,0.14752182,0.010983244,0.0036721064,-0.006845315,-0.030240888,0.012267814,0.021818439,0.028503912,0.12734258,0.047680214,-0.08485396,-0.14129236,-0.02883401,-0.012999974,-0.033703346,0.042395607,0.00043337143,-0.041312788,0.03328526,-0.04084308,2.6742506e-33,0.053244542,0.05176528,-0.054371793,-0.026681215,0.026296245,0.0016016057,-0.09989789,-0.011820778,-0.02045074,-0.00352309,0.017359072,-0.08648993,-0.015676104,-0.018067727,0.04745081,-0.040783502,-0.0037785668,0.012435015,0.03619684,-0.025776489,-0.047297478,0.08672467,-0.043552123,-0.011086501,0.0396376,0.0062016756,-0.07189033,0.038413644,-0.058821708,0.016474485,0.058455285,-0.03318573,-0.11922094,0.010430631,0.012247898,-0.012462622,-0.14149357,-0.069025,-0.00063640124,0.053047057,-0.016406586,-0.003613679,0.027961029,0.007708511,-0.026175646,-0.033300716,0.042873826,0.02726464,0.023830358,0.08859955,0.0015080529,-0.019620307,0.12387442,-0.09786147,-0.03341868,-0.0026913844,0.06290559,-0.08203274,0.009437476,0.075865656,-0.0031823847,0.06808146,-0.035395194,0.036571,-0.021762837,-0.0488499,0.006494948,-0.051028293,0.038977697,0.04313795,-0.036657665,-0.007061847,0.030624546,0.02452463,0.0438493,-0.047492024,-0.03232251,0.06866281,0.024014933,-0.123529516,-0.018396443,-0.000643409,-0.029239742,0.014632032,-0.023356307,0.03221316,-0.03607998,-0.09710652,0.027171617,0.054870624,0.07183448,-0.030121882,-0.055907678,0.051593475,0.009539207,-2.4370893e-33,0.025207063,-0.05813393,-0.047296863,-0.12084718,-0.123401344,0.100744225,0.032488104,0.04929142,0.04926683,-0.0473767,0.08404514,0.036552705,-0.03768592,0.026388064,0.032465234,-0.0029463787,0.12344315,0.043892585,-0.047171935,-0.10760478,0.044556838,0.08048418,-0.027610017,0.09601941,0.026069533,0.06136117,0.011332623,-0.010732812,0.1222139,0.01708599,0.007036609,0.054622106,-0.009837335,-0.023459973,0.012703967,-0.017005607,0.037282713,0.021095917,0.00070282473,-0.012149148,0.054407217,0.078228004,0.005114008,0.07689047,0.0374797,0.027801294,-0.02140077,0.016797258,0.01303401,-0.049666636,0.059304357,-0.05749316,0.014756594,-0.023347432,-0.02390487,0.050310466,0.056464244,-0.06230189,-0.0016422227,-0.0076110275,-0.042784303,-0.008786244,0.0449259,-0.050807353,0.06100535,-0.012319753,-0.035772752,0.023271281,0.013034894,0.013624474,0.087762296,0.04316183,-0.040788516,0.049562898,-0.06820909,-0.039130587,-0.03718022,0.023129487,0.0056047016,-0.016739486,0.037789762,0.026151434,0.034089893,-0.052962158,-0.03581862,-0.08960236,0.020470202,0.08009161,-0.018870095,0.0131596755,-0.018229332,-0.049349654,-0.05025989,0.090065844,0.07429104,-3.8434738e-08,-0.0056271553,-0.03963999,0.01284426,-0.027781183,-0.00848751,0.06479445,0.07591743,0.0011550086,0.09296448,-0.069298774,-0.09074133,0.13324589,0.06164857,-0.019289786,-0.04225272,0.06647323,-0.08035679,-0.07494036,-0.059485726,-0.02840106,-0.009813722,-0.008967379,-0.060554434,0.07917777,0.054469943,-0.04754106,0.051940374,0.034211762,-0.029104501,-0.035712097,0.021945197,-0.023608195,-0.057088684,0.040172864,-0.03925289,-0.011299826,0.049694765,-0.08029331,0.025835212,0.021974292,-0.023956675,0.051256657,-0.10335252,0.043768328,0.0133486455,0.025125418,-0.03403105,-0.0635622,-0.046243228,-0.016097218,0.023296667,-0.036760993,-0.00275186,-0.07174219,-0.11895037,-0.030129634,-0.014257642,-0.037773628,-0.017868832,-0.03155059,0.067316525,0.023929039,0.17947158,-0.010188501 +1.1.1.314,"In Lactuca sativa EC 1.1.1.314 is a mutifunctional enzyme with EC 1.14.13.123, germacrene A hydroxylase [2].",384,1.0,0.03773392,-0.083498314,-0.05535344,0.0228005,0.011242155,0.03192858,-0.0050591603,0.1097728,0.004546041,-0.04252032,0.015684832,-0.031979695,-0.031490974,0.026094215,-0.063652694,-0.07886319,-0.06906265,-0.048760556,0.006169499,0.003267795,0.06514006,-0.008009029,-0.014810571,0.1051916,0.07171428,-0.032563005,0.03641257,-0.019177299,-0.018678501,-0.058696058,0.023456367,-0.065637946,0.044682074,0.0123750325,0.010798935,-0.0061110286,-0.018132357,-0.17078145,0.016596004,0.013312989,0.050352287,-0.030861238,0.015423463,-0.024349736,-0.016368145,-0.065094925,-0.008155063,0.022363665,-0.023221808,-0.014949569,-0.047689345,-0.041861314,-0.039250582,-0.0040247524,0.052119475,-0.0041756965,-0.027331926,-0.0696621,0.015320661,0.0880067,0.042111967,0.05298867,0.029742517,-0.004497801,0.006874064,-0.01664978,0.0910053,-0.15634157,0.008765631,0.0077854306,-0.110110566,-0.08547792,0.03092722,-0.0065496396,0.032530304,-0.018077977,-0.0067865313,-0.018184243,0.07798331,-0.0034207301,-0.013321924,-0.04564114,-0.09810989,0.08759943,0.020477662,-0.05321769,0.0493505,0.023795864,0.08984261,-0.029588854,0.020744305,-0.013787712,-0.07534187,0.0061761923,-0.034752507,0.05812877,0.014250694,0.029897766,0.0075139413,-0.056149837,-0.0044655367,0.09405103,-0.032788325,-0.06764905,-0.08937077,0.04221769,0.096284956,0.048863254,-0.004878756,-0.04084805,-0.0640153,-0.064242885,0.029078187,0.016114967,-0.09417744,0.08765169,0.058394417,-0.098905355,0.019134346,-0.035727628,0.025925376,-0.0080327885,0.074076,0.06732927,-0.019334404,0.01599422,-0.02063932,5.211809e-34,0.05776159,0.0064435485,0.045322213,-0.03585759,-0.00077795767,0.060692526,-0.09081379,0.07999776,-0.08072563,-0.031899553,-0.03782974,-0.033586454,-0.0062779663,0.075542994,-0.03736579,0.013255618,0.011604513,-0.030849531,-0.0030805343,0.00558022,-0.027695304,0.048328772,-0.048391882,0.09174711,0.023049656,0.011662456,-0.05203667,0.032931555,-0.0220095,0.03505211,0.016554873,-0.07932636,-0.118146144,0.06975355,-0.024330668,0.0026815769,0.0025210006,0.009976909,0.053175207,0.06999002,-0.015087844,0.0989086,0.092499204,-0.051982712,0.047123358,0.0070827217,-0.033443116,0.12710373,0.11928232,0.017666627,-0.026673278,-0.03706314,0.026856579,-0.032413084,0.026598893,0.054821867,-0.053191893,0.12775727,0.078230806,0.03349384,0.021518106,0.027027423,-0.028854538,-0.0037601504,-0.026559956,0.071899995,-0.06627936,-0.037911225,0.057293143,0.044025224,-0.09104388,0.009561479,0.021801013,0.0034021053,0.034161106,-0.03510191,-0.061612926,-0.014515363,-6.188394e-05,0.07190082,-0.05997849,-0.021124579,-0.003658823,0.029648429,-0.03185134,-0.004716655,-0.06426779,0.040080573,0.0027352055,0.053789586,0.015237735,-0.019120354,-0.02112215,-0.03481577,0.00811766,-1.7373513e-33,0.044243325,-0.06425581,-0.0061454577,0.008265971,-0.02266082,0.0033806628,0.04132888,-0.019351395,0.08680035,0.0073786564,0.12666425,-0.068137,0.046342254,-0.14288525,-0.006449756,0.058850825,-0.033586465,0.042175155,-0.0052796174,0.06563554,0.00035768867,0.07948176,-0.005139652,-0.001887482,0.077067874,0.02102835,0.005451141,0.076829724,0.0076296916,-0.00749441,-0.088921696,0.027389528,-0.06824556,-0.04733584,-0.09274459,-0.019854615,0.042547632,0.02002575,0.00068981684,-0.009672227,0.026858114,0.06255848,0.021174356,0.05967201,0.085774325,0.08275533,-0.004854698,-0.025497776,0.0026116592,0.0053506955,-0.04311209,-0.047250886,0.018239146,0.028524794,0.008331852,0.040532332,-0.009875145,0.041408382,0.028075272,-0.06254829,0.013893664,0.07438988,0.011157053,-0.03802038,-0.013913916,-0.024661422,-0.11416884,0.0028522266,0.017001588,0.0011808748,0.06115891,-0.043734565,-0.012008414,-0.00028782946,-0.060302835,0.014733179,-0.091834836,-0.06891083,-0.014009177,-0.060853526,0.09675318,0.059213124,-0.014593534,-0.06744587,0.05164681,-0.011378124,0.012070289,0.093192525,-0.02038955,0.028410349,-0.08766633,-0.014026731,-0.12788033,0.022440681,0.08948049,-3.473776e-08,0.01293525,-0.021657439,-0.070683524,-0.04378203,0.06945319,0.012384605,-0.03890794,0.039436806,0.025582988,0.0063970815,-0.008665814,0.085971005,0.01951157,0.019304702,-0.022178076,-0.018692374,-0.0407276,-0.00722298,-0.023150386,0.056013137,0.020498602,-0.049538862,-0.09861164,0.019793555,-0.014293565,-0.06685724,-0.023058577,0.0671962,-0.018674582,-0.08847311,0.026156945,0.04406381,0.07045356,-0.02763637,-0.042571872,0.068122484,-0.041954074,0.00069815526,-0.021640118,-0.0031516913,0.032684285,-0.08678187,-0.041171703,-0.050611783,-0.004362187,-0.008595921,0.007616642,0.015871959,0.0107366,0.000956558,0.038984384,-0.050831515,-0.030285789,-0.020248402,-0.000120679426,-0.026670536,0.010031806,-0.07361262,-0.011831495,-0.06843366,0.05493798,0.028960416,0.15656126,-0.06764236 +1.2.7.10,Contains thiamine diphosphate and [4Fe-4S] clusters. Acceptors include ferredoxin and the nickel-dependent carbon monoxide dehydrogenase (EC 1.2.7.4),384,1.0,-0.028877772,0.01719583,-0.0898371,0.014574394,0.11823839,0.03118957,-0.01587971,-0.020958494,-0.045383073,-0.07649972,0.015387217,-0.10830999,-0.014694173,0.020812599,-0.04088672,-0.022756288,-0.00145412,-0.038086843,0.031225253,-0.027212152,-0.07581547,0.03792918,0.017922971,-0.039295804,-0.07018333,0.09760444,0.04241078,-0.06423335,-0.026470244,-0.1149237,-0.103407614,0.04782096,0.093322545,-0.05298765,0.0014914803,0.080601186,0.018801605,0.027659342,0.025627447,0.01024452,0.010734235,-0.023907367,0.089301065,-0.039344907,-0.06202237,-0.040336967,0.029682022,0.017550033,0.007347602,-0.010555581,-0.019705078,0.00345608,0.015344641,0.101662375,0.056313254,-0.04838632,-0.029446352,-0.027468871,-0.04971536,0.028252825,0.051054012,-0.06921776,-0.019376194,-0.009913325,0.0655949,0.01880535,0.046516985,-0.05705342,-0.022993557,-0.084101684,0.00534257,0.018600604,0.043575566,-0.03182896,-0.03999559,0.15379097,0.06860825,-0.057441983,0.105186306,-0.02868693,-0.024291368,0.010298643,0.06704951,0.054465372,0.053233813,0.017401574,-0.06795886,-0.015360848,-0.054933604,0.0020294262,0.0097646555,0.028156184,-0.06454218,-0.042602006,-0.037441507,0.06081083,0.016846988,0.010195093,0.026278002,-0.010853047,0.03583305,0.07030975,-0.060976308,-0.06961108,-0.05954829,0.037902888,0.006825324,0.06247586,0.049587447,0.045991305,-0.0019992676,-0.03067854,0.04895466,0.044781893,-0.03401366,-0.026694357,0.082166664,-0.0440753,-0.017538575,-0.018637214,0.019274738,0.05026728,0.06332711,0.031615473,0.007514819,-0.01043856,-0.14824133,2.5497598e-33,0.0714772,0.042968944,0.053436775,-0.032160103,-0.00050921855,-0.02497952,-0.08577242,0.02414006,-0.021061832,-0.03319014,-0.09561342,0.0036491968,0.12679532,-0.052718632,-0.026976649,-0.118703686,-0.02546419,0.0012679754,0.08226332,-0.07440768,-0.017759677,0.10890653,-0.10800272,0.077902116,-0.039498903,0.07120527,-0.01247644,-0.0013467665,0.031057645,-0.0039181705,0.08228344,-0.023764309,-0.07093249,-0.049514484,0.031531844,-0.021483673,-0.008024499,0.013754211,-0.071450494,-0.042884823,0.0035602383,0.03318,-0.023247898,-0.059624802,0.0338008,-0.11827721,-0.059779506,0.031251546,0.04358969,0.059749197,-0.01672778,-0.040009778,0.026770454,-0.07047767,-0.06607261,0.020914564,0.019528825,0.057247575,0.082915865,0.06569127,0.0030293763,0.0461689,-0.071274474,-0.009680687,0.012501947,0.010715045,-0.030866552,-0.073942706,-0.012580949,0.060060654,0.031646255,0.04820983,0.12096417,0.028856806,0.005669869,-0.035351623,-0.03733575,-0.021156479,0.024386462,-0.013279277,0.028180603,-0.033701945,0.0015733337,-0.011794515,-0.04211183,-0.05009728,0.017107347,-0.06897407,0.037584364,0.021177901,-0.0023227008,-0.008693607,-0.057002794,-0.068745196,-0.012661096,-2.865867e-33,0.12681754,-0.022975218,0.046716448,-0.064416625,-0.040473603,0.040338863,0.04821018,-0.02687121,0.0727824,-0.027124962,0.14187801,0.00074806804,0.07764359,-0.06357018,-0.010516963,0.08542648,-0.042529475,0.063292064,0.06959516,0.012383354,-0.015630316,0.009841219,0.014597006,0.07114128,0.06214871,0.039063178,-0.013339736,-0.008184062,0.060604386,0.06328422,-0.042082623,-0.011129837,-0.0575072,-0.004119003,-0.03692276,-0.03247375,-0.06703938,-0.015374843,0.020037953,0.007166292,-0.03027215,0.02616204,0.0027917435,0.14265268,0.06886627,0.016814997,-0.014365626,0.055299085,-0.030786948,0.025699547,0.007058349,0.0046653403,-0.09427431,-0.00072348706,0.07440759,0.041686516,0.06696204,0.019322347,-0.016131697,0.012273925,-0.007454412,-0.11278539,0.07805007,0.034495756,0.028587671,0.010420606,-0.04816515,0.05791324,0.063904814,0.029016856,0.036573898,-0.016074814,0.108670294,-0.04026433,0.007923294,-0.009486202,0.020544644,0.011666661,-0.047864616,-0.005978674,-0.009425731,0.038827367,-0.01719731,-0.036540736,-0.0028877214,-0.03803452,0.05356245,0.049955845,0.01244035,0.011453803,-0.074493095,0.014554173,0.012030744,0.0474676,0.02882053,-3.3510645e-08,0.0043330905,-0.06486044,0.02841685,-0.050128378,0.0060651717,0.06817272,0.06603734,-0.0040640747,0.015005613,0.0053185443,0.08216383,0.069719784,-0.042603392,-0.051157154,0.100332856,-0.050743207,-0.058484245,0.0093873,-0.038914226,0.03195161,-0.049931716,-0.0071154158,-0.044882007,-0.04014304,-0.0117791975,-0.024041843,-0.02341512,-0.10059771,-0.035384104,-0.061115544,-0.018197352,0.056740995,0.0051965807,-0.11531792,-0.032918338,0.023558686,-0.0025829403,0.012454125,-0.06755611,0.04310349,-0.004568157,-0.04796609,-0.10133758,-0.023859594,-0.032269906,0.008764974,-0.023425788,0.07348021,-0.027030278,-0.037991084,-0.060677387,-0.010946243,0.011542826,-0.014189186,-0.0657018,0.066277824,-0.050234947,-0.024933185,0.057264112,-0.043757297,0.011962164,0.02763093,0.11894864,-0.012102232 +1.3.1.87,This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.,384,1.0,-0.018342104,-0.03352068,-0.04864893,-0.021556024,0.11685329,0.023219759,-0.038011927,0.0134012,0.025456961,0.027020792,0.02556965,0.042396702,-0.040808517,0.02490984,-0.055254363,0.063384995,-0.15008424,0.05656426,-0.030035216,-0.0427135,0.04389956,0.004187928,0.012475078,0.011786063,0.048778776,-0.022848308,0.08383179,-0.041562095,-0.0007842541,-0.020728908,0.07775615,0.00985383,0.033446122,-0.029947912,0.017007342,0.0323275,-0.039869905,-0.06537323,0.005221779,0.015205277,0.034442704,-0.025192734,-0.0427471,-0.0837316,-0.025346251,-0.026380282,-0.047860347,0.020425705,0.05459037,-0.05523884,-0.0330417,-0.037031025,-0.0032177079,-0.011970795,-0.040240876,0.04522522,-0.023144998,-0.0068777977,-0.023972467,0.08043664,0.011144991,-0.0025964018,-0.044584155,-0.026564082,-0.044220388,-0.032947626,-0.0054454785,-0.007195035,0.058849465,0.046909846,-0.09599726,-0.089840144,-0.014706827,-0.00022233148,0.020642955,0.004892946,0.011908371,-0.050234053,0.0073405565,-0.081865765,0.052105043,0.007377607,0.06865779,0.011584641,0.056643806,0.0022908763,0.041734975,-0.028516542,0.11118532,0.03363802,0.028353123,0.028251192,0.0423706,0.0306062,-0.047460202,0.053669836,0.015661208,0.019121919,-0.016468477,0.030872062,0.015945904,0.017104698,-0.0185597,-0.1534803,-0.0635305,0.057457224,0.028004792,0.09401426,0.05617961,-0.0011294853,0.034129046,-0.005824425,0.038983185,-0.016726522,-0.010250864,0.06333291,-0.0035942807,-0.030819729,-0.06825683,0.002580577,-0.06119957,-0.010733376,0.02439724,0.044989843,-0.09689511,0.032041583,-0.03632148,-7.049792e-35,0.031189762,0.02251841,-0.046780832,-0.0015726258,0.0076590125,-0.029005123,-0.08606178,0.025474118,-0.035864808,-0.11389985,-0.05629085,-0.099556185,-0.026489032,-0.06280069,0.01925224,-0.063882254,0.028165678,0.06694962,0.10717414,0.010834594,-0.018546142,-0.024443537,-0.075182505,-0.0034504377,0.058163498,0.060506225,0.00017356154,0.05983247,-0.04632057,-0.02415517,0.018471867,-0.081661135,-0.15696387,0.03672778,-0.021660885,-0.008522115,-0.034304127,-0.053376555,-0.005931453,0.059029903,-0.04163204,-0.03084047,0.00760111,0.020749643,0.02071449,-0.017913284,0.04013713,0.09741448,0.023089297,0.10223592,-0.0055632717,0.005125607,0.08642845,0.054456625,-0.10703088,0.056476824,0.004517779,-0.079380825,0.07056706,-0.011174985,0.014810317,0.08449465,-0.04210436,0.029006192,0.008665441,0.05326088,-0.031026836,-0.033318263,-0.022566942,0.0621033,-0.054001007,-0.02493616,0.07666386,0.01513431,0.1212283,-0.030899648,-0.08218959,-0.0081843855,0.0067181555,0.016933965,-0.04600107,-0.021725347,-0.0155763505,0.029170586,-0.03580949,0.055615563,-0.025480863,-0.08012718,-0.008471869,0.018209415,0.067679435,-0.1442076,-0.01686768,0.048211303,0.008090011,-3.6980556e-34,0.08835742,-0.045628577,-0.01252027,-0.062237233,-0.0353695,-0.009068136,-0.0027631547,0.0094910115,-0.05403516,-0.037125003,0.042199563,-0.074016936,0.022932198,-0.03795179,0.02371399,0.05454332,0.06076629,0.049637776,-0.0063646813,-0.022150788,0.027732609,0.07651596,-0.015048057,0.06284138,-0.025486562,-0.0057904897,0.06507904,0.018426005,0.07606061,0.06103274,-0.02309719,0.011228011,-0.06057524,0.0074655074,0.010292277,0.07946448,-0.056713313,-0.06765034,0.0020202955,-0.011536833,0.011544339,0.033610526,-0.006779448,0.02077365,0.049642134,0.063477695,-0.059551056,0.083844535,-0.0062030144,-0.10635375,0.035611723,0.121335246,0.0023825797,-0.025610369,-0.011905488,0.053587902,0.03751945,0.0023095822,-0.080911,-0.019932352,-0.034206048,-0.07082571,0.059396382,0.06866086,0.041022714,0.05142456,-0.019416116,0.13994202,0.031359468,-0.04798306,0.08236733,0.021465352,0.05659619,0.07834312,-0.04805998,-0.029517526,-0.0010774845,-0.047487292,0.009357927,0.007345583,0.058068916,-0.09345303,0.03663284,-0.11545336,-0.060415745,-0.08029371,-0.027595794,0.022943579,-0.0032183172,0.06087071,0.043957133,-0.047872588,-0.06340337,0.062956296,0.04421927,-2.1346686e-08,0.029611818,-0.04828057,0.052844252,-0.07904801,0.037800413,0.0042803776,0.016824896,0.05657214,0.038550515,-0.025227701,-0.08749723,0.04390545,-0.005097256,0.051674865,0.0011706582,0.07253884,-0.048272077,0.01637802,-0.021593237,-0.014612238,-0.1012953,-0.012708737,-0.10832485,0.065735415,0.015273395,-0.048142478,0.08200317,0.08328695,0.012338402,-0.028717428,-0.0087713385,0.029346997,-0.028485704,0.039937224,0.019424794,0.06217021,-0.009183034,-0.051880024,-0.024514508,0.048176024,-0.04697239,0.008882877,-0.04226961,-0.00090381823,0.0032111472,0.053038873,0.034260426,0.021770556,0.012737379,-0.026149461,0.068175875,0.016404498,-0.04864021,-0.029920716,-0.09435337,-0.038773976,-0.00015536042,-0.04041094,-0.002224244,-0.06128648,-0.026166098,0.040275056,0.19414438,-0.06190327 +1.3.5.5,This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. The enzyme from Synechococcus can also use NAD+ and NADP+ as electron acceptor under anaerobic conditions. The enzyme from Gentiana lutea shows no activity with NAD+ or NADP+ [1]. ,384,0.99999994,-0.11459461,0.0136947045,-0.08193354,-0.019902386,0.06009478,0.062085666,-0.106159955,0.04697968,0.02811268,0.03455568,0.032071944,-0.033388875,-0.09179993,0.020019213,-0.035724014,0.082960695,-0.052756246,0.029594505,0.032808244,-0.025179103,0.0645038,0.001558445,-0.010387304,-0.051075496,0.06908657,0.017497275,0.0015799326,0.015588533,-0.04247432,0.0337002,-0.05318282,0.022223115,0.018428892,-0.06639674,0.0046913354,0.08503704,-0.08371081,-0.047758434,0.020109847,0.034821164,0.031869777,0.0012109951,-0.0758239,-0.011422262,0.04481924,-0.017983252,0.009850547,0.06753925,0.01789415,-0.056274,-0.0355025,0.033348743,0.026437968,-0.06278747,-0.0008878835,-0.024160609,0.0003855427,-0.04442601,0.03705105,-0.035010055,0.048297323,-0.041071683,-0.02332025,-0.02556163,0.06947996,-0.09475948,-0.0008014339,-0.026301982,-0.0033618645,-0.06613335,-0.115057245,-0.050402332,0.010420135,-0.011542675,-0.024536138,0.08053558,0.005078473,-0.023989845,0.0014508327,-0.033678457,0.046171784,0.02134374,-0.05264725,0.04865256,0.087714866,0.050270997,0.010060098,0.05663665,-0.025917739,0.035044413,-0.028320188,-0.027633393,-0.007038063,-0.012377066,-0.113871366,0.046286635,0.06332207,-0.059099153,-0.011931593,-0.056110438,0.01649787,0.10656469,0.036222976,-0.08522853,-0.042685766,0.019962436,0.008322151,0.1170185,-0.025309436,-0.00045142075,0.009989669,0.013061461,-0.021423813,-0.06110067,-0.037333682,0.089992434,-0.03984481,-0.047545347,-0.109933905,0.032893654,0.004061717,-0.055878736,-0.014706681,0.035977654,0.03110945,0.03955426,-0.077272765,4.7621366e-33,0.094089836,0.00592432,-0.06687698,-0.04449148,0.06360708,-0.003121896,-0.05691987,-0.012973371,-0.04253657,-0.08611097,-0.073361255,-0.08313447,0.092523165,-0.018634094,-0.072360635,0.06830292,-0.031128792,-0.07357432,0.045992363,0.032985784,0.033022564,0.045856506,-0.011564455,0.030010605,0.046630908,-0.004873108,-0.05102722,0.01721166,0.02577489,-0.01899293,0.044330522,-0.082844496,-0.10826204,-0.007982174,0.14251463,-0.011735623,-0.03171462,-0.10288874,-0.038033534,0.041389376,-0.08397335,0.1073241,0.03701838,0.033073187,0.0022660804,-0.009173898,0.013177011,0.026145779,0.081843115,0.08689919,0.07376066,-0.02801655,0.088945664,-0.04305219,-0.0054702666,0.065443166,-0.027914466,0.017002573,-0.0063732974,0.04797869,0.013128317,0.04470766,-0.05232318,0.041159317,-0.050014604,0.0389723,-0.09700474,-0.037116624,0.081750534,0.028701594,-0.034675322,-0.038886297,0.014182479,0.08912134,0.03397744,-0.009019924,0.03449268,-0.0100114485,0.015792215,-0.05310383,0.019596023,-0.046273857,0.009113365,-0.05457524,-0.01818325,0.052364465,-0.054711904,-0.041335296,0.008723876,-0.028364547,0.077384286,-0.041430287,-0.011053836,-0.03979694,0.010556548,-5.4323117e-33,0.060391963,-0.03734309,0.041575093,-0.06605271,-0.013477839,0.101221554,-0.07238556,-0.1495002,-0.03649005,-0.026230792,0.05535731,0.03631273,0.06627019,0.0148828495,0.0063154297,0.013226518,0.021109028,0.0964999,-0.053287517,-0.0045533893,-0.011514092,0.076086156,0.07429306,-0.072218865,0.043819968,-0.044506602,-0.076063715,0.054555796,0.02452548,-0.048086096,0.008503448,0.024272837,-0.07819788,-0.04588983,0.052735206,0.034556914,-0.039360553,-0.0072338376,0.025865648,0.0593556,0.012177436,-0.028909665,-0.0054866117,0.066284396,0.023273978,0.014881282,-0.10684933,0.010023314,-0.030424487,-0.013626856,0.07981149,0.03505539,-0.023503708,0.007304968,0.09869552,0.020081658,0.116370715,0.046619922,0.017931225,0.024459777,0.013878404,-0.07684568,0.044546686,-0.0054822066,0.09419353,0.07373314,0.017072802,0.096858785,0.03417486,-0.020515136,0.11172498,0.04429679,0.01117363,0.035953786,-0.04988949,-0.00208983,-0.06323313,-0.033213172,-0.023209654,-0.033935934,0.029915709,0.025325915,0.02707291,-0.037884258,-0.082096346,-0.0053463397,0.035887603,0.032501295,-0.056117237,0.0056209355,0.022845829,0.0075390637,0.0013770183,0.049737956,0.047807995,-3.2472297e-08,0.0038944108,0.009907833,0.028828973,-0.08326554,0.0018200945,-0.019400556,0.026682729,-0.0357264,0.048431292,0.016529469,-0.0014654322,0.07260576,0.030106733,-0.005774379,0.06881987,-0.037855696,0.026156904,0.0072747506,-0.053323895,0.03821934,-0.06263426,-0.0037499913,-0.15935645,0.07189483,0.047921468,-0.10211515,0.016887445,0.0022375411,0.04674933,-0.05946314,0.022904783,-0.020172637,0.030605499,-0.039085392,-0.08898345,0.024233254,-0.04202348,-0.040623266,-0.063375466,0.017234333,0.012191973,-0.06265947,-0.018771328,0.016240006,-0.051170003,0.018392423,0.060552668,-0.03281904,-0.047472503,0.014057065,0.028323933,-0.0445609,0.01819898,-0.06947363,-0.0844636,-0.0016778504,0.036561336,-0.02641557,0.02792802,-0.05616792,-0.011025572,0.009248724,0.12360892,-0.012978229 +1.3.7.8,"An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate.",384,1.0,-0.06230975,-0.026659109,-0.016696837,0.065815166,0.07001995,0.01787118,0.006411475,-0.037976533,-0.0127454065,-0.035393905,0.00056323124,-0.0029106815,-0.056920577,0.012962557,-0.0034175306,0.04246418,0.0009347363,0.022045804,0.014462821,-0.015657946,0.062788464,-0.0030299663,-0.03180249,-0.069480665,0.010408935,0.05733828,0.05598679,-0.022933487,-0.016037771,0.010101286,-0.039553143,-0.07353057,0.022710571,-0.082773775,-0.0015666981,0.108059876,-0.03882783,-0.07700108,-0.048288357,-0.07732417,0.027233407,0.0058420957,-0.03593009,-0.07011757,-0.049298257,-0.08445284,0.0893404,-0.011865885,-0.016194452,-0.008341594,-0.073691964,-0.00013956166,-0.046477225,0.028352343,-0.0008728277,-0.035096806,-0.10841114,-0.011438727,-0.07167639,-0.054268204,-0.045835063,-0.042344555,-0.06293604,-0.04243161,0.08929713,-0.054630507,0.032828655,-0.021013103,0.028396372,-0.0057572145,-0.021996042,-0.03229612,-0.099990934,0.03207151,-0.06017017,-0.009750819,0.00034402084,-0.07912651,0.14382766,0.0037895974,-0.027840761,0.017774664,-0.006270426,0.103952646,0.110063724,-0.012590012,-0.023081819,0.024886478,-0.0087037925,0.0604824,-0.005447236,-0.0066092378,0.024351731,0.017409826,0.0052412665,0.03128774,0.02671552,0.044418737,-0.029772118,0.03830537,-0.023190165,0.1279222,-0.05341429,-0.06589005,0.0070662186,0.013112938,-0.0035404442,0.14098735,0.010216816,0.06607116,0.03745719,-0.06322231,0.03920958,-0.013113885,0.029774109,0.07017411,0.048642267,-0.10460381,-0.07896149,-0.01547351,0.01583105,0.030767325,0.021840567,0.08048005,-0.017981758,0.038656022,-0.14099301,5.927826e-33,0.04143245,0.040197458,0.06506399,0.019238027,-0.06543714,0.020427983,-0.078313485,0.010886606,0.07887583,0.0016744072,-0.07218731,-0.052776724,0.05584216,0.012413277,-0.022736717,-0.09618459,0.02633865,0.06444519,0.16604598,0.032034617,-0.039580815,0.07813931,-0.00085148646,-0.048381753,-0.023323892,0.048866987,-0.04897881,-0.018905506,-0.06258179,0.008589711,0.053944822,-0.12345713,-0.09562407,0.009713257,0.054669373,-0.06295354,-0.06026765,-0.050007984,-0.020036412,-0.03031984,-0.032030717,0.0023175948,-0.078616746,0.0010055541,0.056042127,-0.056020327,-0.021834692,0.06328986,-0.013145118,0.061762664,0.02958287,0.00045865015,0.08162538,-0.017848112,-0.10420496,-0.007085153,0.01730378,0.013180524,0.012838168,0.080975436,0.032135095,0.045605764,-0.0075041014,0.06283707,0.020182071,-0.042284977,-0.045789782,-0.015991984,0.0024063764,0.079836436,-0.038501658,-0.0010858625,0.06604991,0.03287823,0.0023237725,-0.057844818,-0.024119917,-0.020049457,0.052681096,0.072278336,-0.03597579,-0.07525657,-0.015187401,0.030390518,-0.081029125,0.023262355,0.0074730767,-0.024323111,0.038666707,-0.015129942,0.034789078,-0.03379194,-0.072455846,0.061064385,0.038018864,-7.772687e-33,0.06159967,-0.043885153,-0.0031143213,-0.11958673,-0.08944954,0.019404994,0.059877805,-0.06706994,0.01203682,0.015927639,0.08452834,-0.06548737,0.05241126,-0.04543301,0.019534267,0.049459513,-0.02344608,0.009205453,0.052047275,0.03681072,-0.0054932614,0.13141723,0.009093291,0.082723774,0.014858461,0.0107091,-0.03048364,-0.017065886,0.06888029,0.08603663,0.013952178,0.022054138,0.009274161,-0.123241924,-0.03000828,0.03779797,-0.021798395,0.035548095,0.020140648,0.012064899,0.039543603,-0.021558555,0.04295109,0.11927544,0.03713284,0.0016599552,-0.025528071,0.016267342,-0.045340523,-0.04219153,0.07349612,-0.018461479,-0.039313592,-0.0028691047,0.02429751,0.020030117,-0.026058402,0.009549722,-0.0012578286,0.045458917,-0.070817724,-0.039821245,0.057014156,-0.02054563,0.017968988,0.04658985,-0.03965451,0.0074062184,-0.012327294,0.028643984,0.039142597,0.013055816,0.08241105,-0.019554012,0.069525,0.0028481653,-0.025930969,0.04021388,0.010300645,-0.05068251,-0.037688475,0.073716015,-0.027617073,-0.07411446,-0.0039027461,-0.07851032,-0.025381511,0.01873465,-0.03952957,0.015226616,-0.01869888,-0.03477518,-0.036626603,0.06976229,-0.083376,-4.5142446e-08,-0.06655792,-0.049273126,0.07259648,-0.020992234,0.0021993658,0.05711754,0.043229293,-0.08640649,0.032056555,0.000825655,0.03083467,0.09100324,-0.025175696,-0.026802521,0.03727181,-0.012647114,-0.045720354,0.06860206,-0.04886087,-0.08553973,-0.04183391,-0.03562787,-0.063980065,0.059858825,0.056132074,-0.06818797,-0.005286176,-0.0594152,0.0501951,-0.029265255,0.036265854,0.03329519,-0.0004942374,-0.012744885,-0.03428342,0.02248476,-0.01657334,-0.052737355,-0.059272215,-0.03135867,-0.07350083,0.043543052,-0.050629288,-0.015311413,0.074761085,0.053238858,-0.0527951,-0.0016069778,-0.07220661,0.024568774,0.08374726,-0.05649051,0.029416485,-0.081762806,-0.0747198,0.033663005,0.046738792,-0.06580809,0.0021016847,-0.015749274,0.07786093,0.004413654,0.092494845,-0.047502942 +1.3.7.9,A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3].,384,1.0,-0.06907112,-0.023145871,-0.12657845,0.07482583,0.10755122,0.042158246,-0.031624015,-0.02992938,0.033203676,-0.10076052,0.005307705,-0.08132206,-0.05056391,0.043426752,-0.056366142,0.015048012,-0.076353565,0.051674634,-0.04610038,0.027773201,-0.015193117,0.017076543,0.06714073,-0.035013665,-0.022755431,0.06332553,0.018104738,0.007242063,-0.045353867,-0.05199831,0.026976315,0.06269474,0.10395057,-0.04496208,0.020652536,0.12108872,0.058719486,-0.07284266,0.059703782,-0.0077745942,-0.017800253,0.040002495,0.06497306,-0.05912605,-0.032403074,-0.031086935,0.03956162,0.001344222,0.06745792,-0.028710729,-0.018262137,-0.012867507,-0.059418175,0.09676068,0.03130689,0.039594214,0.0040151994,-0.060381737,-0.02043021,-0.057849463,0.018116111,-0.027221933,0.0577145,0.021590404,-0.040724438,-0.030504832,0.018714417,-0.055548307,0.016620805,-0.04971099,-0.057072133,0.0048461403,0.039297197,0.00248031,-0.04206613,0.132539,0.08083786,-0.024758276,0.08603601,-0.04254145,-0.046625346,-0.041764736,0.019476626,0.057264473,0.038904272,-0.060692433,-0.067688115,-0.040051516,-0.0064017135,0.07715982,-0.0053675426,0.061433617,0.04015165,-0.038941078,-0.08650022,0.0121005075,0.079630956,0.010412332,-0.0019408691,0.02986698,-0.034197524,0.07901045,0.01630324,-0.077478126,0.0013048087,-0.06511091,0.005508334,0.14096247,0.041014344,-0.0023390993,0.05276205,0.0070140064,0.097576715,-0.037314914,0.020169467,0.05074196,0.02880318,-0.034906045,-0.08801169,0.018787337,-0.00920084,-0.027454816,-0.012247829,0.019567335,-0.02967625,-0.050250784,-0.11021228,1.2173591e-33,0.15336554,0.017652404,0.045663424,0.028510517,0.018483307,-0.042201377,-0.11331087,-0.0188246,0.047904104,-0.07921546,-0.06752469,-0.040650077,0.10827741,-0.074381545,-0.014640739,-0.0659485,-0.10349426,-0.066079274,0.09590782,0.005479215,0.023366094,0.033947416,0.036292233,-0.024409203,0.045581974,0.07985806,0.00027851897,-0.026479715,-0.02932176,0.029066611,0.046681676,-0.07182556,-0.1100536,-0.00463579,0.028536186,-0.007303733,-0.036626957,-0.057095442,-0.053264983,0.02513635,-0.05705691,0.022723725,-0.009484558,-0.05815248,0.054359585,-0.008803252,-0.03229969,0.10016882,0.05483258,0.08366135,0.0003355423,-0.08009572,0.07853339,-0.005582501,-0.07576397,0.04463441,0.01510253,0.028895756,0.00690385,0.056256086,0.03888451,0.06367863,0.0054481025,0.054116517,0.0073727528,0.026569998,5.4171967e-05,0.0011610201,0.030212425,0.07134756,-0.03343089,0.03140763,0.066086106,0.037417307,0.008180798,-0.012666191,-0.024064535,-0.10784567,0.02102418,0.005084276,-0.0032141444,-0.060313065,-0.013490267,-0.06996314,-0.049845338,0.015691128,-0.046736106,-0.0035542916,0.0035799479,-0.027680121,0.045554847,-0.049039878,-0.03777978,-0.034225855,-0.08391912,-1.6192683e-33,0.07593646,-0.06657753,0.017957706,-0.038159117,-0.07759849,0.02403704,-0.049793337,-0.014889084,-0.010494281,0.05180087,0.07277585,-0.0027306953,0.052195348,-0.075740695,0.053766843,0.033738866,-0.0028911717,-0.032929804,0.046054825,0.034631435,0.016126297,-0.011615222,-0.018031046,-0.009050386,0.045984533,0.049588483,-0.0539221,-0.014991827,0.0659604,0.03491059,0.012420815,0.001129993,-0.063220546,-0.11067177,0.006671354,0.010683831,-0.026216025,0.009893929,0.034670103,-0.041199222,0.025295142,-0.0068961177,-0.009907281,0.09094589,0.049297504,0.03828926,-0.08722759,-0.00018167218,0.004659289,0.026219044,-0.035483822,-0.014930716,-0.060023423,-0.007467975,-0.019724192,0.050992932,-0.0036713092,0.045006145,-0.0061964137,0.011354249,-0.042455703,-0.104545094,0.06771285,0.04553643,-0.013088258,0.08692113,-0.007829571,0.061701357,0.031403515,0.0013228715,0.013211673,-0.017029025,0.045629468,0.069824636,-0.008454787,-0.013182628,-0.0036498504,-0.0015489627,-0.0050558057,0.051770743,-0.023691181,0.015710842,0.010445677,-0.067136176,0.045625374,-0.10527946,0.011586765,0.08800464,0.02809275,-0.0064781657,-0.025374418,-0.022245936,0.0059594726,-0.04923696,-0.026202017,-3.133544e-08,-0.0523862,-0.056455627,0.050823133,0.0081728045,0.040697,0.07061488,-0.012574526,-0.016306683,0.021736568,-0.004480815,0.060495418,0.10534764,0.011468093,-0.054098807,-0.0016978876,0.08589964,-0.08697725,-0.0522401,-0.029730389,-0.014841867,-0.04926734,-0.040082775,-0.11596683,0.12259476,0.06570559,-0.05505872,-0.025150286,0.006420184,-0.013784955,-0.072116226,-0.020760652,0.034583762,-0.013268809,0.003353368,-0.09880977,-0.027235914,-0.034320466,-0.058587674,-0.0309236,0.041109987,-0.039759647,0.020903436,-0.061809774,0.009547141,0.03767901,0.0678545,-0.03206247,0.06595854,-0.012000275,-0.015967347,0.04031702,-0.049091995,0.0072841304,-0.0059516286,-0.13599904,0.08299587,0.012675742,-0.017840475,0.06359027,0.03049333,-0.017164806,-0.018341182,0.0763942,-0.059434664 +1.3.8.1,"Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme catalyses the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms. The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. The highest activity was reported with either butanoyl-CoA [2] or pentanoyl-CoA [4]. The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA [6]. cf. EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.",384,1.0,-0.05181725,-0.083428666,-0.05252567,0.013957317,0.10234684,0.024609506,-0.14706017,0.044441517,-0.022720149,-0.010136937,0.019963484,-0.024287988,-0.094431385,0.044055544,0.011788926,0.006185926,0.013637163,-0.05258895,0.027411455,-0.07488468,-0.00034420445,-0.031530704,-0.027421098,0.0018636159,0.07929426,-0.02869565,0.063324876,-0.054340534,-0.031831,-0.08922669,0.02438805,-0.08557813,0.079691224,-0.05102051,-0.013356701,-0.00091759197,-0.0041944194,-0.06894895,0.037737116,0.04083815,0.028402202,-0.02519114,-0.016420363,-0.011329944,-0.0075711505,-0.118084274,-0.031863324,0.02216526,0.034361325,0.023512436,-0.032754846,-0.0075278278,-0.010716048,0.027105056,-0.028794479,-0.007415896,-0.030467696,-0.03980532,-0.036515046,0.021471934,-0.017140163,-0.039918948,-0.024055663,0.018828718,0.0065567754,-0.025408108,-0.017465346,-0.031357083,-0.0032037832,-0.014992451,-0.04961919,-0.04996179,0.0032152324,-0.025230506,-0.016987206,-0.01657499,0.0016343589,-0.06077994,0.06784527,-0.036857817,-0.020780148,0.032075915,0.0087139495,0.045479342,0.03513828,0.0140763465,-0.03124532,-0.03689056,-0.0672534,0.050680365,0.069641344,-0.005074901,-0.019991755,-0.045455508,-0.008741034,0.08111794,0.05967704,0.0074604345,-0.014371404,-0.039148558,0.0019619977,0.07563132,-0.07887493,-0.087569684,-0.013951779,0.056448303,-0.05605965,0.11352218,0.032071985,0.026059005,-0.011473323,-0.029694747,0.0078913625,0.035286818,-0.0003490672,0.07125798,0.017517433,-0.08004745,-0.07060853,0.057301488,-0.021931846,0.016788933,0.11134341,0.073072314,0.026892703,0.028505925,0.013949313,3.328888e-33,0.039650615,0.019058853,-0.05224772,-0.036883734,0.009330527,-0.010477026,-0.093990184,0.11011384,-0.011760371,0.016598312,-0.007083525,-0.0081905015,0.032270897,0.011811568,0.057114843,-0.053287305,0.06109079,-0.0068475287,0.10920206,-0.0064951577,-0.018043408,-0.009271962,0.025892423,0.02454521,0.029222107,0.014165901,-0.02551579,0.08181664,-0.012782536,0.016538402,-0.031660754,-0.0666552,-0.0038562592,0.024246858,0.023582146,-0.032726705,-0.06613867,-0.028404197,-0.06755153,0.094081864,0.07411865,0.016218446,-0.009366205,-0.072811455,0.020466667,-0.055952895,-0.022294685,0.083029024,0.012002718,0.055277772,0.09046441,0.018350068,0.11822165,-0.07204956,-0.03247427,0.03486425,-0.053680602,-0.019423772,0.0785967,0.017967684,-0.018314036,0.08187646,-0.04664958,0.08424865,-0.043524094,-0.021480728,-0.14099064,-0.031416487,-0.04774836,0.099151276,0.017845549,-0.0032374866,0.079457425,-0.016704299,0.058045648,0.010322282,-0.038581867,0.035691395,0.05140723,-0.045023266,-0.014373426,0.022800269,0.036972303,-0.018624833,-0.0101547185,0.022762982,-0.034919593,-0.051782977,0.048789594,0.04794563,0.016401472,-0.06631706,0.0030772649,-0.037465498,0.10191189,-2.8204777e-33,0.11842093,-0.106524386,0.022967031,-0.108968906,-0.033259906,0.039483886,0.02658126,0.004747269,0.09964078,-0.03362503,0.07024296,0.0127624385,-0.026201293,-0.07527605,0.0943172,0.09493124,-0.001409455,0.09047507,0.0026032992,-0.06380386,0.0018800872,0.009008542,0.012277023,0.07473227,0.045650896,0.028386688,-0.027193712,-0.019385455,0.07639556,0.026860984,-0.004501117,0.011399923,0.00089675566,0.012892533,-0.019204825,0.021668866,-0.0697448,0.06633633,0.005483353,0.047010113,0.0069311713,-0.0033204174,-0.03626091,0.0070457384,0.051746525,-0.008766369,-0.118398875,-0.0933836,-0.0063374094,-0.11621721,0.02595991,-0.028892301,-0.013735655,0.020294743,0.048499603,0.079546586,-0.0016586235,0.04787284,0.09501387,-0.09434327,0.008477515,0.02137676,-0.01462531,-0.022338105,0.061903566,-0.032172322,-0.05305921,-0.005054919,-0.038179755,0.022967625,0.045135852,0.031896293,-0.008907354,0.0537204,-0.02285864,0.0067419447,0.019196788,-0.038384125,-0.028996855,-0.0021762364,-0.039392725,-0.04410232,-0.037365917,-0.022586064,-0.07777265,-0.023402339,-0.01446446,0.1026703,0.027606554,0.074151255,-0.006011608,0.02261019,0.010135789,0.024300477,0.0960239,-5.239045e-08,0.014962398,-0.090777814,0.036772043,0.01932482,0.00323456,0.09315391,0.053995434,-0.06611482,0.047656473,-0.04944422,-0.043341465,0.1170954,0.026345018,0.015259526,-0.014063294,-0.05094397,-0.013039681,-0.02829866,0.0110603385,0.012969179,-0.09820803,0.010736995,-0.015656581,0.0015729255,-0.040981002,-0.09850537,0.02517053,0.04017455,-0.005954825,0.031806577,-0.06611613,0.03140418,0.007154634,0.00019117855,0.025023952,-0.01649962,0.11428386,-0.025897307,-0.09793171,0.117541015,0.024858871,-0.022907792,-0.057880104,-0.009749831,0.029765835,-0.058008373,0.0214893,0.048257574,0.007972582,-0.01976888,-0.026295118,0.025829474,-0.09138657,-0.037124153,-0.019860834,0.0014653446,-0.014022915,-0.118399315,-0.08235625,-0.081936546,0.09914639,0.02143688,0.1728698,-0.03964485 +1.3.98.1,"Binds FMN. The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.",384,0.99999994,-0.0895791,0.0024903533,-0.10065659,-0.11111854,0.012866011,-0.024237005,-0.06316068,0.06487875,0.020404791,-0.014764327,0.030741597,0.0131330425,-0.176711,-0.011117841,-0.033946097,0.04392019,-0.071501434,-0.02015917,-0.019081578,-0.039518636,0.024078269,0.014866618,-0.026705483,-0.053018488,-0.0694032,0.024664998,0.025025245,0.09180395,-0.010046264,-0.05057861,-0.034824047,-0.04300104,0.031174816,-0.0035117697,-0.05443158,0.113589376,-0.0054615224,-0.040119156,0.02263097,0.05940506,-0.0075504775,-0.0016368997,-0.06099867,0.035962857,-0.020338781,-0.030591179,0.03949943,0.07556393,-0.016072398,0.021273999,-0.02867437,0.0508072,-0.033354685,0.011118292,0.040079933,0.03124623,0.01649657,0.016676405,-0.10866893,0.020451387,-0.021526903,0.0016190062,-0.0627625,-0.0011866324,0.0060318448,-0.039782066,0.098682575,-0.076569654,0.011149685,-0.02328431,-0.06376692,-0.06420616,0.025915803,-0.020208087,-0.03781599,0.08433976,-0.024363328,-0.012607201,0.008581101,-0.0014905612,0.007254178,-0.049040258,0.031123744,0.033963732,0.077352025,-0.0015699143,-0.092105575,-0.009415203,0.013866622,0.07784756,-0.02315145,0.011950614,-0.008277421,-0.026099026,-0.074263304,0.11295319,0.028857792,0.07974118,0.029843265,-0.042554513,0.0100738,0.06185293,-0.10612439,-0.043675162,-0.05857268,-0.011360318,0.029900324,0.024179347,-0.07139499,-0.02451015,-0.0025847415,0.0037899958,0.079649694,0.0016390836,-0.037761617,0.06898872,0.0024825593,-0.021356141,-0.00247442,0.018975144,-0.039221026,-0.015646748,0.014114917,0.081771515,-0.020847183,-0.025769228,-0.13915595,4.2821316e-33,0.063063726,0.0683278,-0.00782375,0.025747022,-0.017570753,0.030272534,-0.04451487,-0.00798332,-0.09237237,-0.01621863,-0.049784556,-0.046588983,0.07575769,-0.025864925,-0.044503283,-0.04557824,-0.027722139,0.003697295,-0.004006621,-0.0114617,0.052106235,0.043194756,0.026624035,-0.036411956,0.041623786,0.086749256,-0.067906685,0.06330834,0.06227221,-0.008927408,0.009384169,-0.14400227,-0.015434043,-0.002576844,0.027803486,-0.047986194,-0.08168734,-0.013811586,-0.036312267,-0.03001492,-0.033546317,0.06083307,-0.038621496,0.009262226,0.052368682,-0.0014345335,-0.023124857,0.08890197,0.016703488,0.01259221,0.037147403,-0.041647155,0.07944372,-0.07791117,-0.014079154,-0.020319972,-0.025481606,0.017010152,0.024540732,0.15539514,0.0001506711,0.07777908,-0.03992917,0.047134764,0.09388937,0.023023924,-0.04694349,-0.088250674,0.065425985,0.062617525,0.0177385,-0.021709407,0.094637446,0.005489026,0.041258723,0.0040766695,0.0006451206,0.035053156,-0.032354668,-0.02254368,0.051962055,-0.006914432,-0.024275517,-0.016038384,-0.072433,-0.03882586,-0.00804473,-0.008541578,0.059877843,0.041580804,0.04963142,-0.09570029,-0.0042019435,-0.09526071,0.07639743,-4.5714766e-33,0.037478365,-0.038760938,-0.00012708332,-0.07117224,-0.020482894,0.15193266,0.0069379713,-0.075675234,0.038653158,-0.008426549,0.038853448,0.007703892,0.007843387,-0.03649273,-0.07363281,-0.0038854957,-0.041843545,0.0078656245,-0.019092677,-0.001790081,0.014848353,0.08711701,0.049326565,0.10636544,0.018656993,-0.020678675,-0.008678538,0.060365874,0.019884095,-0.016187696,-0.065456934,0.023789523,-0.046533536,-0.004497156,0.05761114,0.03285686,-0.053232193,0.025105093,0.017894233,0.044796966,0.007294412,0.011734873,-0.0015550394,0.06415973,-0.012938266,0.08182995,-0.10383644,-0.013253935,0.014580293,-0.020773344,0.02069326,0.039704368,-0.061931714,0.031989045,0.13473973,0.023857445,0.012429681,-0.038811263,0.010951148,0.016815959,-0.020760842,-0.13451396,0.031234233,-0.0034475767,-0.01076144,0.016047109,-0.030989647,0.13573937,0.0052790204,0.06217468,0.0629937,0.047863003,0.06641075,0.008621883,-0.045883533,-0.013109128,0.0009942265,0.0016799613,-0.011245633,0.06489137,0.017342867,-0.009409397,-0.03558714,-0.02803409,0.04409586,-0.007841458,0.0792094,0.054130502,-0.010542976,-0.058565706,0.07248065,0.0040668054,-0.025436295,0.056071054,0.015718682,-4.216461e-08,0.03537309,-0.07405687,0.10596412,-0.03397671,-0.004888249,0.053252224,0.036023483,0.036953628,-0.016197879,0.030048512,-0.021231705,0.098458305,0.06515255,-0.028016543,0.04999355,0.03828804,-0.03830885,0.0056275977,-0.01252154,-0.016827786,-0.031098962,0.023976777,-0.12705256,0.043769404,0.05266273,-0.0703619,-0.009778721,-0.08694483,0.035440087,0.0014815326,0.031602126,-0.022654174,0.04226347,-0.03767753,-0.076503806,-0.067542784,-0.01886621,0.044024132,-0.08988455,0.008626948,-0.010843374,-0.06895637,-0.051380634,0.030045219,-0.009964859,0.05805549,-0.008133692,-0.012371475,-0.034276377,0.028205466,0.055911228,0.030802561,0.044564616,-0.082567975,-0.11862958,0.0060875835,-0.044645365,-0.029724937,-0.03823292,-0.02321614,-0.0034158544,0.02812893,0.17250842,0.013617346 +1.4.98.1,"Contains tryptophan tryptophylquinone (TTQ) cofactor. The enzyme oxidizes aliphatic monoamines and diamines, histamine and ethanolamine, but not secondary and tertiary amines, quaternary ammonium salts or aromatic amines.",384,1.0,0.032536633,-0.051993113,-0.062966816,-0.059872616,0.019683711,0.07015441,0.020582397,0.012224071,0.0009359601,0.025936604,0.033667594,-0.057152335,-0.0454143,0.13301657,-0.02170104,0.04089318,-0.0039979694,-0.06520879,0.06692855,-0.06669363,-0.004971739,0.10938061,0.05323437,0.00055548904,-0.033598084,0.09852639,-0.021035295,-0.0030055067,0.08374445,-0.036348138,-0.10143315,0.035326675,-0.029406035,-0.05154894,0.07903114,0.03359493,-0.034251858,-0.022765912,0.020773618,0.033748113,0.0147108715,0.029339174,-0.007485271,-0.021013629,0.041370537,-0.03394325,0.015325198,0.039241083,0.022892034,-0.01830328,0.007889396,-0.029776191,0.051538743,0.043264527,0.03348879,0.040661596,-0.051184326,0.0060847946,-0.0377552,0.08112585,-0.0043981657,0.09748107,-0.0020803327,-0.04340409,0.110606864,0.04594446,-0.030955449,-0.052569795,0.010909622,-0.04652107,-0.08253111,-0.10003437,-0.039261647,0.07474121,-0.053473007,0.028545875,0.030999487,-0.09049151,0.01270589,0.005707871,-0.045061216,-0.03188471,0.026316922,0.11289779,0.06857055,0.043039158,-0.08255228,0.02742617,0.018356415,-0.010965856,0.0280072,-0.026801497,-0.017201133,-0.07402374,0.03325724,-0.0017257637,-0.0058280574,-0.0128391655,-0.0027591886,-0.005689375,0.042277567,-0.023967477,-0.113320775,-0.07024684,-0.08989077,0.020035125,0.05265069,0.01193434,0.06699572,0.020090785,-0.04814803,0.060758475,0.06690112,-0.009374574,-0.026238974,0.006039357,0.052360088,-0.009498618,-0.015670849,-0.046123326,-7.899032e-05,-0.0014460876,0.0026848656,0.09274334,0.037612576,-0.022729825,-0.04237031,4.7917077e-33,0.11591602,0.05322868,0.06327057,-0.03659133,0.0013678682,0.07614414,0.0056717996,0.020634348,0.013118378,-0.018322693,-0.091571845,0.007177784,-0.016901068,0.0010328853,0.048699096,-0.011471519,-0.12000631,-0.0015377502,0.03927415,-0.048575446,-0.042738814,0.061671186,-0.026596226,0.028218683,-0.01053282,0.030051388,-0.041506894,-0.0073732655,0.005642587,-0.009320138,-0.06100601,-0.00024154405,-0.116963096,0.048547853,-0.04006664,0.007586035,-0.06636409,0.03448853,-0.117326014,0.050753515,-0.02542685,0.081089035,-0.018421026,-0.017649364,-0.023180561,-0.1377117,-0.020148639,0.025547806,0.025805147,0.010876051,0.0346669,-0.0048544346,-0.04493427,-0.034219388,-0.071948,-0.019091133,0.039704382,0.0033720026,0.055482257,0.09372651,-0.06757825,-0.056767184,-0.053377207,-0.0057579693,-0.0008770531,-0.011658757,-0.025792697,-0.090011515,0.025431123,0.053416103,-0.035549343,0.012325804,0.06771899,-0.008432424,0.031402394,-0.042797785,-0.032335866,0.06566905,0.027278839,-0.031405903,0.06951049,-0.1428923,0.02401963,0.027427025,-0.050185803,-0.013962233,0.075528555,-0.045113493,-0.01622324,0.019062787,0.004455735,-0.03835238,-0.014661237,-0.01662151,0.013973922,-5.579863e-33,0.04045599,-0.06742545,0.007107273,-0.06963081,-0.020675892,-0.04351784,0.0349564,-0.061037518,0.06383905,-0.069624715,0.11012401,-0.0467829,0.046298627,0.0049959538,0.0024382188,-0.026025256,-0.0033874493,0.12153757,0.011761735,-0.048811764,0.0051604104,0.05366591,-0.027903408,0.012809382,0.085517235,0.035379097,-0.022482134,0.018450584,0.052035473,0.038927585,0.0005243724,-0.021065515,-0.063163385,-0.025388917,0.028268047,0.030422743,-0.022330036,0.033601582,-0.05804263,0.007756404,0.04444324,0.022977436,0.014883181,0.06493219,-0.043299973,0.06780852,-0.12287499,-0.045162175,0.015379011,-0.013968685,0.06712034,-0.00994093,0.011267025,0.0068877386,0.036543366,0.031664845,-0.03917925,-0.03170344,-0.017752407,-0.023442136,-0.019464994,0.06596911,-0.031042889,-0.056714155,0.03200521,-0.037709523,0.001914977,0.059332244,0.066490866,-0.024392724,0.02995445,-0.02733434,0.13557994,0.06052179,-0.066919796,-0.07048242,-0.044959866,-0.018882671,0.06889764,-0.022325266,0.047131825,-0.02751225,0.0045422716,0.029802525,-0.034428492,0.02293622,-0.008585277,0.11812012,0.030268691,0.08477325,-0.014605906,0.019679561,-0.009000541,0.08215794,0.06489576,-3.820419e-08,0.024291763,-0.0979223,-0.034071177,-0.018449463,-0.059500817,0.05225695,0.033569273,0.0014998554,0.033966944,-0.047612652,0.07349949,0.046589755,-0.022286419,-0.013872266,-0.028475536,-0.018788187,-0.045584373,-0.009511113,-0.015484323,-0.07144675,-0.12866123,0.0050524287,-0.028229482,-0.035760254,-0.028782148,0.006150089,-0.010641209,0.073211834,0.032361627,-0.002618125,-0.040840026,0.02330423,-0.008437514,-0.09913983,-0.09759377,0.04152431,0.0380488,-0.011264018,-0.044969622,-0.04996388,-0.010526067,-0.04848279,-0.09476391,0.014412443,0.04576926,-0.05900971,0.028733123,-0.0028792059,0.048953317,-0.0743956,0.020556157,0.0042034728,0.009993344,-0.023961063,-0.097710796,0.005803545,-0.015254842,-0.06263518,-0.02823488,-0.12147244,0.05734374,0.032122057,0.22738898,0.0047186906 +1.6.5.9,"A flavoprotein (FAD or FMN). Occurs in mitochondria of yeast and plants, and in aerobic bacteria. Has low activity with NADPH. Unlike EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating), this enzyme does not pump proteons of sodium ions across the membrane. It is also not sensitive to rotenone.",384,1.0,-0.05642913,-0.04958767,-0.13668346,0.017148541,0.096376054,0.01841696,0.008804868,0.08642772,0.05924256,-0.061330907,0.025601385,0.03453426,-0.09466636,0.012860454,-0.11385262,-0.008393537,-0.04533963,0.0016132426,-0.059844635,0.0036539696,0.008606968,0.045103397,0.06741699,-0.048186757,-0.013101679,-0.078674,-0.002016022,-0.020474218,-0.028864788,-0.04064797,0.064910285,0.08378636,0.023690438,0.015733441,-0.028479418,0.05821545,0.049064193,-0.040960163,-0.014681278,0.03244022,0.034313165,-0.044911526,0.038316675,-0.0135190915,0.074823074,0.015895186,-0.028709168,0.050357085,0.04486876,0.034590844,-0.015720569,-0.02020152,-0.02808227,0.09050716,0.030948924,0.0536412,-0.00066839426,-0.06726733,-0.040385693,0.038690887,0.00918631,-0.0012070596,0.03172329,-0.011744569,0.07562846,-0.0606953,-0.0387765,-0.033841465,0.034323942,-0.013157771,0.026311437,-0.040496137,-0.06787425,0.034205776,-0.003872634,0.09986249,-0.05973332,-0.018100537,0.03616223,-0.0047611827,0.07487612,0.0028419436,0.0702703,0.053348023,0.07393771,-0.060418494,-0.009659941,0.0010042512,-0.048256148,0.116312005,-0.037011556,0.05272614,0.008175543,0.0053038034,-0.13027544,0.062120665,0.074093394,-0.0039048973,-0.08472622,0.019941488,-0.019683942,0.030595578,0.048307136,-0.01773486,-0.08360706,-0.032172494,-0.006705639,0.048745755,-0.012993328,-0.04856442,0.018876465,0.019013273,-0.0008456448,-0.102181345,-0.030690411,0.023234803,-0.014583534,-0.07168035,-0.060034677,0.028849361,-0.083524965,0.0712309,-0.020096222,0.099094935,0.0634512,-0.014073147,-0.16931279,2.28079e-33,0.07823716,0.0117754005,-0.007908397,-0.019600578,-0.029858455,-0.011528271,-0.06964525,-0.009857523,0.04472035,-0.082702294,-0.031236209,0.024557658,0.004382165,-0.053984985,0.027335392,-0.020940566,-0.043671604,-0.06606314,0.06866547,-0.081829496,0.061816867,0.0063877166,-0.019674357,-0.02200893,0.03127389,-0.025960483,-0.0789607,-0.0047760233,0.006681896,0.028868448,-0.0069100433,-0.08938449,-0.029737264,0.046175115,-0.011372942,0.043239452,-0.078986086,-0.06400234,-0.10941819,0.07596716,-0.021538416,-0.0044419435,-0.042449113,0.016319195,0.07172907,-0.05349486,-0.050338674,0.084499724,0.007925315,0.10406697,0.03867583,-0.026915945,0.104176536,0.028445857,-0.021720402,0.015044306,-0.003579688,-0.007997746,-0.017556157,0.016750535,0.014444453,0.054052353,-0.063932456,0.10566313,-0.020553658,0.014748818,-0.04651943,-0.056075845,0.02124759,0.07100686,0.02411403,-0.045264527,0.10367951,0.013781179,0.029041441,-0.008071955,-0.026968941,-0.024976239,-0.03448821,-0.013023214,-0.0027887805,-0.08089867,-0.05719927,-0.010796793,-0.074211024,0.06567525,-0.00075210497,-0.021039562,-0.028150083,-0.012984409,0.08603574,-0.029334165,0.0013273444,-0.025934946,0.045345977,-1.7542997e-33,0.008921486,-0.07421028,-0.0018794107,0.012573689,0.01803224,0.059918266,0.021542117,-0.031392697,-0.0138424495,-0.05801579,0.006223104,-0.08687703,-0.028673561,-0.02981052,0.045935474,-0.0028526394,-0.026810538,0.050510805,0.066621594,0.058209747,-0.07941564,0.08089696,0.030462585,0.11506837,0.024307253,-0.0020287319,0.009326286,0.00384915,0.011213452,0.02558879,-0.021515256,0.056746557,-0.065147005,-0.0439522,0.008057308,0.021580841,-0.048068825,-0.020328134,-0.0115983775,0.016412651,-0.001555328,0.021484489,-0.010777371,0.024097318,0.02320138,0.083228946,-0.084068276,0.0255395,0.09182834,-0.025837999,0.036948204,0.017929533,-0.032431476,0.05785277,0.0323613,0.033205472,0.040611073,0.07552449,0.018189354,0.04039414,0.026609378,-0.07973751,-0.01013939,-0.060971253,0.07283044,0.045250814,0.03161739,0.13115682,-0.014662396,0.051025257,0.12696178,0.014721217,0.05139044,0.0676804,-0.036607977,-0.012881312,0.0050361757,0.06803889,-0.016990721,-0.0093579795,0.00472065,0.0056778304,-0.009615059,-0.012057828,-0.04517228,-0.08205498,-0.034155715,0.03801005,0.0016035249,0.036881972,0.032706153,0.051696535,-0.05964469,-0.05828887,0.012912555,-3.678374e-08,0.05959434,-0.058744516,0.022701874,-0.017865054,0.0992023,-0.014459418,0.04509304,-0.00204646,0.011856191,-0.009964165,-0.065300286,0.10550807,0.020619651,-0.047894195,0.08770403,-0.032006737,0.017978178,0.05195553,-0.039317418,-0.018771037,-0.06932793,0.042507425,-0.114134945,0.0119550545,-0.054162372,-0.045133274,0.04159346,0.002585323,0.08940761,-0.082850344,0.030262437,0.028724944,0.053775676,-0.043043666,-0.14576939,0.04214475,0.036070816,-0.061415102,-0.0888238,0.018654054,-0.10850081,-0.032137208,-0.0020889225,-0.029597089,-0.05031807,-0.032373052,0.0685892,0.012204671,-0.012406511,-0.02092505,0.0054706475,-0.017232534,0.0085227825,-0.012448928,-0.10323868,0.013394955,0.0074569387,-0.05556079,-0.008991823,-0.08929753,0.0038089328,0.014315075,0.10355596,0.032364577 +1.7.1.14,"A heme-thiolate protein (P-450). The enzyme from Fusarium oxysporum utilizes only NADH, but the isozyme from Trichosporon cutaneum utilizes both NADH and NADPH. The electron transfer from NAD(P)H to heme occurs directly, not requiring flavin or other redox cofactors.",384,1.0,-0.038782977,-0.006480607,-0.09143112,-0.018197283,0.08667472,0.013172756,-0.029872108,0.0721063,0.033158302,-0.023334704,0.067359604,-0.051125534,-0.11412935,0.074960165,-0.028804854,-0.021182932,-0.044306777,0.018950066,0.016298514,-0.08342772,0.026377412,0.045317255,0.039473347,-0.004797443,-0.0046021324,0.007517132,0.050976694,0.07874991,-0.002990367,-0.0886736,-0.026006136,0.00499264,-0.02325804,-0.030231562,-0.002168264,0.102051,-0.052786622,-0.03677428,0.03922416,-0.026369391,0.06862711,-0.07524503,-0.030234585,3.7155787e-05,-0.043661624,-0.017199906,0.011512481,0.09742364,0.013756794,0.018109882,-0.006314383,-0.010426139,-0.047415778,0.0651878,-0.026913613,0.023734277,0.09539981,0.015377371,-0.032398928,-0.037792936,-0.042015105,0.0018711739,-0.07214541,0.0077276677,0.012069332,-0.0640213,0.04425495,-0.02634869,-0.037033595,-0.064218186,-0.042927537,0.003618345,-0.029657006,0.005091015,-0.050248824,0.097207,-0.064218156,-0.019939845,0.027680716,0.026189025,0.07326697,0.043608196,0.029181398,0.07939006,0.051434007,0.0020214005,-0.09111602,0.044346564,-0.063969955,-0.052593216,0.023485316,0.02835649,0.0031305016,0.030228091,-0.12551574,0.06260957,0.054989353,0.037430994,-0.025773397,-0.021042412,0.0063913474,0.050345413,-0.0051817796,-0.060480975,-0.05937702,-0.007156998,-0.018898396,0.06399497,0.086259656,-0.029271867,-0.04410176,-0.010186347,0.06797843,-0.09204497,-0.030175248,0.07064487,-0.022185357,-0.01702504,-0.05899341,-0.04021151,-0.036014397,0.015773471,0.020888926,0.0072328444,-0.017939718,-0.0342239,-0.120352216,5.8864658e-33,0.11460492,0.07616059,-0.015119555,0.019283744,-0.031053917,-0.037012473,-0.06869022,0.002912502,-0.04335048,-0.008428784,-0.07401348,-0.0781584,0.03334806,-0.069390915,-0.0029161938,-0.007772729,-0.04801536,-0.01287227,-0.012405283,0.055271525,0.006095055,0.06954104,-0.016701087,0.04485283,0.08212774,0.036406577,-0.028745681,0.023197718,-0.0030231755,0.0051420075,-0.011026529,-0.05239592,-0.06739727,-0.042895563,0.055488147,-0.019109229,-0.0529392,-0.050977655,-0.076097935,-0.028868547,-0.019687431,0.036907423,0.0002477672,-0.07092354,0.050920457,-0.11968466,-0.051775366,0.06858022,0.032143507,0.10330712,0.08016613,-0.03012979,0.13265277,0.019929487,-0.045385856,-0.012903316,0.02655134,0.039568815,0.058611516,0.07543382,0.11076323,0.052368805,-0.049704596,0.070080645,-0.040124018,0.04273245,-0.07917442,-0.040246256,0.050121766,0.09912939,-0.0145996455,0.028863633,-0.015796242,-0.02008946,0.041309517,-0.064585224,-0.011596013,-0.014198389,0.06107478,-0.027230548,0.05784559,-0.051172,-0.025266472,-0.060032565,-0.069487825,0.030191248,0.025651079,0.043537915,-0.03430765,-0.042196758,0.11280758,-0.08210516,0.019568687,-0.056894187,0.04042649,-4.8316234e-33,0.07021101,-0.007103994,0.011770049,-0.11188786,-0.0162428,0.09157789,0.0417795,-0.04798325,-0.013995575,-0.027433174,0.06020915,0.022364335,-0.029484306,-0.03793432,0.029606408,0.045630477,-0.030334676,-0.032864667,0.031244002,0.007499936,-0.023858452,0.075385764,0.01349739,0.0006876983,0.019145928,0.010613597,-0.037135687,-0.0008448578,0.065670766,0.0478191,-0.07954959,0.0328108,-0.04011202,-0.008521748,-0.030207092,-0.0043273773,0.025411848,0.054824177,-0.008792807,0.0055119256,-0.029511014,0.034185454,0.04111453,0.08551284,0.04128819,0.09622979,-0.16698875,-0.048893437,0.006134386,0.008611236,0.015271613,0.058164414,-0.06714887,0.02380242,-0.006335927,-0.034196433,-0.026845992,0.015301423,-0.045212634,-0.054173134,-0.07332143,-0.081840776,-0.028769137,0.057041466,0.06902288,0.06192018,-0.041002978,0.071013,0.049563084,-0.035629485,0.042977966,0.07246488,0.07412976,0.025886796,0.008937284,-0.039446175,0.0075959223,0.07569454,-0.012653069,0.04888336,-0.003951975,-0.0015028311,-0.036106467,-0.08328302,0.005955334,-0.06981413,-0.028658224,0.016250333,-0.015733382,-0.016888868,-0.0075263274,0.04250699,0.031217944,0.025859632,0.028125254,-3.7250885e-08,0.0045254948,-0.07547214,0.027352612,-0.031746704,0.015481573,0.031045737,0.067326926,-0.0060864184,0.041126885,0.024200397,-0.0083647575,0.10809212,0.014273699,0.031795483,0.032803092,-0.009511745,-0.016856872,0.04697757,-0.019383047,-0.018959008,-0.020471409,0.036657978,-0.070330665,0.08303646,0.054042555,-0.01070571,-0.03039412,-0.07918715,0.02516246,-0.0053043906,0.006840123,0.036048148,-0.003713136,-0.044234194,-0.054807585,0.042133775,-0.009047271,0.027955238,-0.06234492,0.04883414,0.017386006,-0.068132296,-0.08117112,-0.006174469,0.036180668,0.0005966957,0.04266554,-0.020602763,0.00864422,-0.039730962,0.050302878,-0.010748788,-0.004604224,-0.07870325,-0.14751208,0.007419412,0.05682521,-0.0062940097,-0.0025174636,-0.14063175,0.07502672,-0.01544516,0.19533813,0.013216765 +1.7.2.5,"The enzyme from Pseudomonas aeruginosa contains a dinuclear centre comprising a non-heme iron centre and heme b3, plus heme c, heme b and calcium; the acceptor is cytochrome c551",384,0.99999994,-0.08265996,-0.035360355,-0.106560476,0.032395422,0.049968436,0.020779131,-0.050813593,0.06920967,0.009001778,-0.020306049,0.063655496,-0.106279045,-0.030815698,0.08676867,-0.065804526,-0.004480836,-0.06340259,0.0036735353,-0.012081826,0.02301029,-0.05133179,0.10332013,-0.045619648,0.033939846,0.0019719126,0.020954655,0.056793205,0.035135932,-0.026368087,-0.009789066,-0.060571793,-0.0779183,0.17942512,-0.035036325,0.08539972,-0.006086204,-0.030282423,-0.013644567,0.118509024,0.015335629,0.023094943,-0.009736774,-0.0048928326,-0.071366794,-0.029303879,0.0183005,0.020885028,0.015381664,0.08260546,-0.028011467,-0.045264672,-0.025341341,-0.0235027,0.09768125,-0.019744983,0.04082913,0.023783216,-0.11872786,-0.016763167,-0.050748177,0.010398751,-0.06222998,-0.052284114,0.009082909,0.005927664,-0.04261735,0.059915267,-0.004985751,0.045655087,-0.049069952,-0.036243305,-0.03411801,0.04363969,0.016707603,0.025950728,-0.033057105,0.032410137,-0.011360765,0.058233418,0.012858299,-0.01240469,-0.023317121,0.034874093,0.123256534,0.02577758,-0.018369276,-0.024936968,0.047209833,0.0058169398,0.013018086,-0.0027082972,-0.03284207,-0.06708505,-0.14939745,-0.03957721,0.027770128,0.049135458,0.07724069,0.037600387,-0.023931254,-0.01365385,0.023069168,0.015254498,-0.1324448,-0.019994106,0.0070327525,0.025834784,0.07725371,0.09483178,-0.031067705,-0.0021152112,-0.01845704,0.01981592,-0.051378876,0.003909557,0.032535043,0.075604826,-0.044317227,-0.0056901276,0.09341496,0.03169198,-0.058090523,0.040609587,-0.012303863,-0.0014154932,-0.031180851,-0.109698676,3.944348e-33,-0.042020753,0.06558224,-0.02222653,-0.055400006,-0.012003463,0.017086409,-0.090785936,0.014473345,-0.03005199,-0.021499978,-0.06554132,-0.035260014,0.00801254,0.019679345,-0.0055306805,-0.023170456,-0.032213006,-0.0109334905,-0.0068289028,-0.043499872,0.08833494,0.031756148,-0.015856598,-0.016321918,0.052894976,0.036039956,0.021187723,0.00785737,-0.026350237,0.0099127935,0.04010226,0.00032505952,-0.071559325,-0.058899004,0.105829306,-0.010608227,0.00032261014,0.0024339296,0.007454033,0.05731197,0.021543432,0.04495659,-0.03940844,0.0137203345,0.08303806,-0.027710164,-0.12464266,0.105897665,0.06303603,0.107044004,0.058481943,-0.06371172,-0.002411191,-0.016689109,-0.025482964,-0.0057962365,-0.010390579,0.02225569,0.02200496,0.035467744,0.07133301,0.045856576,-0.039483305,0.015681397,0.01783657,-0.02446009,-0.044753637,-0.060774993,0.029849686,0.05229766,-0.10892695,0.0034990811,0.030297311,0.09687443,-0.042890195,-0.08203193,-0.07582166,-0.014357294,0.033046078,-0.037511155,-0.045650855,-0.024909442,0.009757659,0.019834127,-0.10579209,0.0015026843,0.050702475,-0.03354461,-0.040180486,-0.06199795,0.032637786,-0.12853256,-0.048046306,0.018662276,-0.008113969,-4.839838e-33,0.09554309,-0.08420338,0.054752715,-0.059633296,-0.07693979,0.054272074,0.006707741,0.001140614,0.08117558,0.037363417,0.15577744,0.05451052,0.023946332,0.0118453,0.055266738,0.111652225,0.04436324,0.017149506,-0.041180093,-0.023962466,0.029001715,-0.05243954,-0.024816273,-0.00171011,0.03548508,0.07172344,-0.091339484,0.06663117,0.087598704,0.10710979,-0.08904663,0.050328113,-0.017692078,-0.0632087,-0.05189007,0.007889453,-0.006311852,-0.0065715406,-0.0009158342,0.010013905,0.0751237,0.020943642,-0.0019003433,0.13570848,-0.022458134,0.01516542,-0.037686035,0.0010790984,0.025098257,-0.08459846,0.015689451,-0.023563005,-0.018045548,0.04876308,0.014183317,0.04090471,-0.0031148025,-0.020144667,-0.079963475,-0.03959347,0.027079798,-0.0783758,-0.0043640337,0.0044022184,0.03811254,0.034777295,0.004055386,0.053155515,-0.0087889545,-0.019160021,0.01985507,-0.011883055,0.053809043,-0.03504607,-0.035558943,0.018372225,-0.01694428,-0.0017475369,-0.0034368683,0.011456819,0.009179708,-0.01339291,-0.048438653,-0.0453109,0.046259943,-0.03433377,0.019469442,0.06982795,-0.040279824,-0.035154298,-0.031783868,0.017152395,0.0950667,-0.002870315,0.017750809,-3.7637882e-08,0.0283297,-0.07509908,0.030262003,-0.015028389,-0.0037007837,0.038006213,-0.07450636,-0.0461823,-0.010579515,0.04282034,-0.02573427,0.081542715,-0.0703435,-0.02610281,0.05297788,0.06571488,-0.085428156,0.030900031,-0.0048756143,-0.06859004,-0.06754275,0.005230808,-0.07580097,-0.04356692,0.0014771619,0.00064760324,0.011882716,0.028172769,-0.008518075,0.014805758,-0.011799763,-0.002115634,0.010507768,-0.013760947,-0.04522858,0.0071520275,-0.046773646,-0.050833467,-0.08021974,-0.019977286,0.09265853,-0.06230566,-0.1294397,-6.118407e-05,-0.0007474355,0.0082764095,0.018621515,0.036197167,-0.016246643,-0.092577696,0.08117504,-0.040172093,0.03527197,-0.010205519,-0.10402648,0.055140514,0.009449722,-0.059938766,-0.019844105,-0.029681236,-0.0041947295,0.01845584,0.08639795,0.028533276 +1.7.5.2,Contains copper.,384,1.0,-0.028342815,-0.01007315,0.03386799,0.05119997,0.07688927,-0.054589987,0.072899535,-0.00573365,-0.036603812,-0.0651722,0.01006279,-0.0695092,0.0154880565,-0.025170932,-0.055813253,-0.10843538,0.05979265,-0.014604046,-0.04317516,-0.0019154713,-0.008088838,0.04180415,0.08444386,-0.003450686,-0.045035917,0.1364347,-0.016889876,-0.01232536,0.02364901,-0.05726697,-0.0038555327,0.04807803,-0.04100731,0.016716544,0.027921975,-0.02494299,-0.047765817,0.027471635,-0.0053193583,-0.015035485,0.017899474,-0.040704165,0.12944399,0.048077155,0.072758816,-0.039124575,0.050279632,0.0015513492,0.020027978,-0.007516332,0.013548931,-0.02426347,-0.03287879,0.062463988,0.069093,-0.021611318,0.010875639,-0.020214602,-0.017964484,0.002388709,0.019354507,-0.0049732276,-0.085990034,0.046191923,0.06617588,0.0051831696,-0.02357735,0.015210409,0.013315382,-0.013645314,0.041908585,0.048542187,-0.053718843,0.046260472,-0.02347001,0.118639365,0.20318638,-0.10646587,0.05343265,0.025361849,-0.08162243,0.08368275,0.03694763,0.024675654,0.096452974,0.04604352,0.027105529,-0.039326403,-0.19545077,-0.08246974,0.07433434,0.039929423,-0.034269597,-0.020216549,-0.016108073,0.044188052,-0.02359133,-0.00020452886,-0.050524574,0.04333483,0.019789854,0.065508656,-0.0061680702,-0.07719271,-0.094662815,0.015859155,-0.02650612,0.08699712,0.018842867,0.044370428,-0.01588487,-0.026515253,-0.05598691,0.036847807,0.025961882,-0.044730335,0.047681186,0.007997966,-0.09188607,0.024135152,-0.0150522385,-0.024068594,0.0020835022,0.0025336,-0.030470202,-0.076859005,0.028830506,-4.9828857e-33,-0.06097614,-0.045127492,0.06455878,-0.046204187,0.05645315,0.049128667,-0.02939756,0.016011553,0.018991165,0.017227015,-0.05771189,0.0061344234,-0.06191999,0.032375015,-0.023977008,-0.018177774,-0.026944254,-0.0049388134,0.083308175,-0.08297123,-0.04537151,0.056591976,0.025392039,0.0077438266,-0.0030225704,-0.09521982,-0.0042801336,-0.060511395,-0.010669318,-0.024594054,0.034695704,0.0121536,0.05366634,0.050014585,0.0056684,0.06710682,0.004260026,-0.007823178,0.020793881,0.062927425,0.0055263415,0.011592218,0.056609496,0.061421268,0.0126995845,-0.07271746,-0.074713446,0.052221358,-0.051391006,-0.018666953,0.0528036,0.014837169,0.012101733,0.0073815575,-0.022094982,0.002845664,0.02752782,0.037800275,0.049756628,0.02972116,-0.029535223,0.07808912,-0.0417003,0.050463974,-0.039340522,0.04777312,-0.025419686,0.030885337,-0.008221485,-0.004669988,-0.061924376,-0.00547782,0.07194317,0.0034261725,0.020954002,-0.008097885,-0.0524752,-0.011083585,0.102244705,0.039843544,-0.08867762,-0.076601826,0.025255501,0.017887503,-0.037830938,-0.012904672,-0.023969427,-0.0067997077,0.10745064,-0.056281477,0.033894222,-0.060422517,-0.06647386,-0.09553613,-0.018216508,3.5000014e-33,-0.0023577157,-0.0037937385,-0.016826516,0.03642605,0.010671641,-0.075069636,0.019409548,-0.02808436,0.093796365,-0.0555229,0.123620056,-0.014671868,-0.016922537,-0.06279126,0.043564346,0.07387098,-0.033564467,0.18259732,0.008926363,-1.6477508e-05,-0.08042132,0.014866501,-0.01874176,0.008557059,-0.013729052,0.011934004,-0.044261683,-0.053790446,0.042231128,0.004325523,0.015931316,0.0017440227,-0.09301453,0.009942147,-0.15028486,-0.057595782,0.06960273,-0.035497226,-0.043475136,0.03735964,0.04676077,0.0016208213,0.041234083,0.15205488,0.0012163358,0.0074055516,0.016883254,-0.03640005,-0.04173364,0.07182405,0.08908662,-0.0042179013,-0.010264841,0.032918375,0.04247881,0.05291778,-0.022067718,-0.014161533,-0.07155096,0.0054675005,0.036248334,0.036424525,-0.050491072,-0.026917156,0.04496967,-0.019691925,-0.013678008,0.101593584,0.032621752,-0.053953778,0.10728297,0.057635218,0.014368082,-0.112786606,-0.03782247,0.0008397397,0.0005324302,0.027939536,0.053032126,0.028090907,-0.035779424,-0.0073699085,-0.024357084,-0.012884867,0.0039186864,0.013428111,0.007971285,0.007214599,-0.0049414756,-0.009300511,-0.07936344,-0.062009048,0.021632552,0.054372497,0.018970754,-1.1884849e-08,-0.0008321638,0.010171238,0.00015764705,-0.045751143,0.022814019,0.08175832,0.13110085,0.035883017,-0.022336828,0.03675733,-0.018798817,0.025347691,-0.058810804,-0.035892002,0.0016287275,0.023418108,-0.008563521,-0.010019138,-0.034791216,-0.00888493,-0.04238938,0.010328407,0.028095031,0.015274959,-0.0668236,0.0026497564,0.027776472,0.035719976,-0.052286122,0.061663818,-0.007492723,-0.05267497,-0.043754924,-0.027573852,0.022239968,-0.029680012,0.0777168,-0.008117063,0.0055958917,-0.023222532,-0.09917804,-0.05627287,-0.03558246,-0.030117745,0.029601788,-0.07110733,-0.074933134,0.0520597,0.013905821,-0.053709906,0.0061197146,-0.0031811781,0.018607441,-0.04861438,0.002673942,0.008296569,0.023147076,-0.03545125,-0.051116,-0.0233102,0.025097087,-0.06749712,0.18282132,0.046118375 +1.8.1.17,A molybdoprotein.,384,1.0,-0.06795891,-0.051050715,-0.019057672,0.044272188,-0.033386532,-0.042053353,0.07470007,0.06436317,0.011820321,-0.09433792,0.014841155,0.025495434,0.040172234,0.049295817,-0.08847643,0.068639845,-0.00801913,0.023353152,0.0041052937,0.07937946,-0.039030418,0.07685675,0.03585003,-0.010382031,-0.041513443,0.023883611,-0.030241068,-0.029123386,0.0022328924,-0.08169118,0.042665645,0.04248166,0.0025172867,-0.026778806,0.07112569,0.046550076,0.0050762095,0.029474948,0.01848392,0.059414875,0.01762486,-0.0066930335,0.02003669,-0.024805296,-0.018162135,0.014740977,0.05865787,0.043279238,0.033118524,0.08251361,-0.08934847,-0.14480932,-0.07474392,0.06775675,-0.022519989,-0.016007885,-0.07655727,0.057681836,0.01018291,0.01713736,-0.008993773,0.04941753,0.078707926,0.077776715,0.061552756,-0.080438055,0.032757543,-0.0548698,-0.02094294,0.066382475,0.034252074,-0.011767397,0.044701956,0.061630394,-0.06439368,0.0019758143,0.015796652,-0.040091615,0.15729588,-0.011975125,-0.0074430536,0.02890534,0.019339671,0.04011684,0.020330131,-0.006063504,0.028886763,-0.0049521797,-0.07365756,-0.031534284,-0.012910723,-0.06205139,-0.033720315,-0.012237756,-0.07577406,-0.040826317,0.043677304,-0.06322,-0.06744852,0.078937374,-0.04130564,-0.03214647,0.029476268,-0.06068609,-0.050760966,-0.05124476,-0.055168983,-0.036271796,0.017716214,0.07957754,-0.022806596,0.04719726,0.043725777,-0.03192733,0.03603124,-0.018830366,0.018615898,0.042027406,0.04726328,-0.024877356,-0.009966039,0.031821933,0.002508394,0.037773963,-0.06722225,0.076759994,-0.039701927,-2.643452e-33,0.11337477,-0.033667278,0.06242231,0.05737901,0.001807107,0.0077924356,-0.034526426,-0.039194223,-0.06397631,-0.09414348,-0.043655794,-0.03332225,0.024889989,0.07805882,0.04803982,-0.041637935,-0.07500175,-0.049129803,0.05569346,-0.06410469,-0.057308596,0.1043447,-0.030800143,0.07007939,-0.0030803462,-0.013098602,0.008045305,-0.014720466,0.02594325,0.043961752,0.015103776,-0.021615079,-0.060662158,-0.045679968,-0.004674042,-0.020817932,-0.043450303,-0.09071103,0.0148519,0.0021357927,-0.07328164,-0.038703624,-0.057787262,-0.057579223,0.037653476,0.018869916,-0.016334983,0.06834672,0.00018444822,-0.029398866,0.043622572,-0.06807415,-0.0056690243,-0.029094888,-0.12440965,0.05096781,-0.097281374,0.0041178926,-0.028941715,0.056051124,0.020763218,0.07849765,0.0040940293,0.03628676,-0.08005934,-0.057161033,-0.08676286,-0.04884637,0.046623893,0.010687662,-0.02518146,0.00728868,0.114376515,0.035246067,-0.034045212,-0.04597642,0.08640964,-0.063003704,-0.011238245,0.06307535,-0.029933482,-0.014420416,0.015187643,-0.04944344,-0.00069359335,-0.02785217,-0.037331946,-0.08425451,-0.025487006,0.060369678,-0.012160568,-0.014395013,-0.06165436,-0.008136449,-0.11329068,-2.363114e-34,0.07502399,-0.12250633,0.1383093,0.039620712,-0.016723277,0.019759327,-0.023120645,0.008866934,-0.022092761,0.008543426,0.0003691474,-0.04298349,0.051028285,-0.09318412,0.048270363,0.007394089,-0.019605571,0.01915066,0.030218795,0.007764399,0.0019451595,0.008549216,-0.018999867,-0.00026617205,-0.035355147,0.046117578,-0.03876494,0.0023417699,0.011873674,0.06582755,-0.0043823654,-0.00090603257,-0.14710104,-0.10763239,-0.042070236,0.062842,-0.004215525,-0.04076416,-0.006980841,-0.07031991,-0.00812976,0.0031558007,0.047591265,0.12326461,0.08351932,0.040960964,-0.010532052,-0.014990546,0.029615028,-0.007859416,-0.062153433,-0.005728969,-0.010260938,0.010342677,-0.03302128,0.001341689,-0.048913293,-0.057557926,0.01813652,0.02797244,0.0143492045,-0.022724519,-0.016114224,0.0666486,0.027599348,0.10887575,-0.017657219,0.028178576,0.076041885,-0.03002551,0.04549224,0.019736217,-0.000727643,0.045513265,0.04487961,-0.0058322386,-0.12272104,-0.017359976,-0.045811117,0.021776697,-0.043467212,0.009799824,-0.012564255,-0.013509061,0.073926255,-0.051603623,0.011359572,0.08472074,0.029634811,0.018587735,-0.06552438,0.005348266,-0.10338387,0.023143971,0.100776374,-1.9004013e-08,0.016450722,-0.0967033,0.031378403,-0.115559764,-0.014093448,0.08850245,0.0037599287,-0.024001922,0.02588224,-0.030484248,0.042713955,0.07336885,0.00040634398,-0.023039514,0.021264363,0.07632707,-0.04685348,-0.02718001,-0.011425887,-0.0254998,-0.008798341,-0.01658251,-0.0038803213,0.114505254,-0.03512402,-0.0017676152,-0.027935915,0.0726031,-0.108697616,0.058988076,0.019564528,0.06384071,-0.039534837,-0.037468668,-0.029826576,-0.0005900016,0.019985855,-0.0136116585,-0.020982567,0.05961954,-0.012681027,0.010525174,0.031051273,0.03258693,0.0548073,-0.032074373,-0.0303674,0.047534868,0.0074094036,-0.009330029,0.023100594,0.037101213,-0.03992006,0.047643293,-0.127151,-0.017325576,-0.015360584,-0.063588865,-0.07500665,-0.013110663,-0.03344831,-0.00020754371,0.15007296,0.019741865 +1.8.2.3,The enzyme from Allochromatium vinosum contains covalently bound FAD and covalently-bound c-type hemes.,384,1.0,-0.09564267,-0.010164813,-0.092645384,-0.027987547,0.047766767,0.06670883,-0.12105314,0.16508846,-0.013961317,-0.0059056133,0.021115668,-0.024627091,-0.115461424,0.008697984,-0.04914459,0.010818676,-0.05048006,0.012988038,-0.022456989,-0.01303091,0.012381465,0.01902166,0.019574685,0.02481065,0.03208732,0.021652933,0.051487606,-0.0291467,-0.017216181,-0.064986415,-0.0724936,0.02991106,0.08224903,0.011033585,0.09611281,-0.0065260273,0.015079169,-0.07357418,-0.016788047,-0.022955844,0.080983944,0.02712301,-0.051862597,0.049161132,-0.018399807,-0.0030421373,0.088310555,0.023339009,0.005780085,0.056080274,0.03953382,-0.07017005,-0.07327198,0.0010965493,-0.046040405,0.045950856,-0.016128212,0.010070109,0.026299851,0.023086164,-0.06775181,0.01668534,0.0023270536,0.06730137,0.010202795,-0.0069404133,0.06075785,-0.014306816,-0.042924613,-0.03756549,0.05364748,-0.06870904,-0.050489742,0.027570711,0.0013300966,0.094409265,-0.036159053,-0.04412093,0.07068145,-0.023574105,-0.109092385,0.02466544,0.066088155,0.0775439,-0.0043952637,0.07508641,0.020990971,-0.0034511166,0.03446936,0.030415203,-0.004136085,-0.025690373,-0.061374873,-0.0871106,-0.06975039,0.07222342,0.11754305,0.068589635,0.018352393,-0.071573414,0.061627414,0.041597266,0.013723233,-0.04214496,-0.017383432,0.016885728,0.009639956,0.047647398,0.025611032,-0.03673928,0.0063895253,0.002992908,0.046421703,-0.10618107,-0.09365481,0.006014932,0.039571088,-0.032057915,-0.0024312895,0.009739814,-0.05483533,0.021541987,0.047966257,0.06621283,0.017370535,-0.038498998,-0.03976206,4.401389e-34,0.024601568,-0.0101746,0.0023005991,-0.026307499,-0.12103947,-0.0166604,-0.11389186,0.028183248,-0.12423445,0.06472285,-0.02510606,0.008889496,0.032002177,-0.023048667,-0.007932569,0.072522916,0.011882921,-0.07372299,0.03727992,-0.02797169,-0.0002997485,0.03899809,-0.013441769,0.021626815,-0.013620917,0.02700988,0.025784913,0.026427777,0.05790976,0.025965812,-0.03380382,-0.09438609,-0.011239446,-0.011163186,-0.014367371,0.049718652,-0.1049635,-0.008846399,-0.06669187,0.01594306,0.031417135,0.044955228,0.0038370101,-0.029973738,0.048557457,-0.1639976,-0.074234545,0.009195722,-0.041104313,0.06810698,-0.041094135,-0.005938897,0.15109298,0.0097421855,-0.049039543,0.006223829,0.026975947,0.028781278,0.012493573,0.0019800887,0.054239355,0.059423484,-0.051655225,0.044225812,0.008443221,0.032074656,-0.09553799,-1.9267796e-05,-0.019373517,0.07795486,-0.016802916,-0.030613776,0.010813282,-0.019011414,-0.0006655694,-0.039698903,-0.0018937746,-0.039387267,6.156398e-05,0.003390626,-0.030389635,-0.015512969,-0.01276111,-0.042032707,-0.019836271,-0.022402942,-0.0044221818,-0.016138457,-0.043778364,0.040081717,0.0885101,-0.057619825,-0.019867728,-0.0038552333,0.03637862,-1.4490409e-33,0.060360238,-0.033526316,0.043535817,-0.060007427,-0.02729838,0.03872457,0.0038993552,0.011288018,0.004748486,9.9830104e-05,0.11080946,0.014234437,-0.08877472,-0.038380455,0.0002539255,0.07462691,0.019101135,0.045424346,0.01023974,0.008529131,-0.06549107,0.035603706,0.07646346,0.067637876,0.0731065,-0.021032194,-0.072294205,-0.015332162,-0.0040361374,0.076657,-0.0403619,0.0031196198,-0.060050987,0.019903664,-0.034750696,-0.03052506,0.043458004,0.10806975,0.05195836,0.019181937,-0.01569756,-0.043389544,-0.0029387346,0.087499924,0.053841863,0.06859933,-0.114438206,0.06166598,-0.010213172,0.04202114,0.014239979,0.022376928,0.024806986,0.032278698,0.05844956,-0.0041463636,0.035181597,-0.004181029,-0.06820953,-0.08262324,-0.016241562,-0.049171247,0.0021745611,0.02134501,0.057843063,0.07426137,-0.070389144,0.026039725,-0.044704605,-0.024804484,0.0497454,0.06811719,-0.04337095,0.012597003,0.04042519,-0.041109055,0.07540388,-0.019023947,0.022122482,-0.029530253,0.030601189,0.05181009,-0.004087589,-0.009106852,0.039481897,-0.013924525,-0.028277794,0.07872887,0.0032111367,0.020958705,-0.021768762,0.032896377,0.0004981497,-0.008871411,0.057602957,-2.6215545e-08,-0.020370485,-0.0708194,-0.020579675,-0.06655562,0.030351749,0.0029803605,-0.07975243,-0.011023068,0.07552628,0.04833074,0.0067620156,0.123712204,-0.032095183,-0.03166798,0.08862107,0.021387646,-0.025700333,-0.028810656,-0.01945711,0.021960886,-0.012966026,0.03372642,-0.052058052,-0.0056630704,0.014675296,-0.059499666,-0.043630857,-0.06654379,-0.06341497,0.059435528,0.07652415,-0.0094789015,-0.07486189,-0.044501655,-0.008994782,0.018333329,0.027607929,-0.0053444547,-0.052230228,0.016945831,-0.0052989903,-0.025780795,-0.048310336,-0.015303046,-0.021194141,-0.02203261,0.09312157,0.07244414,-0.012584226,0.0150055075,-0.01581516,-0.048602898,0.012516791,-0.10323528,-0.15239568,-0.03280233,0.112592384,-0.102882184,0.0020740237,-0.106766425,0.055512946,-0.050209787,0.15720874,0.004648431 +1.8.2.4,"The enzyme from the bacterium Rhodovulum sulfidophilum binds molybdopterin guanine dinucleotide, heme b and [4Fe-4S] clusters.",384,1.0,-0.043159194,-0.11269464,-0.14445417,0.028868126,0.038701575,0.053235468,-0.0278924,0.03506523,0.04037893,-0.07025389,0.040695153,-0.028190795,-0.06491897,0.07135005,-0.085475564,0.042899318,-0.09461603,0.02577882,0.02248131,-0.029113911,-0.024183065,0.02407076,0.0002702198,-0.028374203,-0.02163908,0.08768231,0.05039125,-0.089338236,-0.033050813,-0.032350626,0.008262881,-0.05184042,0.07270295,-0.004159315,0.04546836,0.11894878,0.06505323,-0.026477458,0.057243586,0.04177237,0.0006152488,0.03975626,0.03592327,-0.011808896,0.01478798,0.030479105,-0.022977514,0.054934416,-0.0029723262,-6.0950344e-05,0.012682184,-0.027906824,-0.053492565,0.08086984,0.023840629,0.04857771,-0.059024636,-0.0044121356,0.085841954,0.017295165,0.03977621,0.010059375,0.1144456,-0.0052780192,0.046963844,-0.06593612,0.11095003,-0.026055062,0.003823727,-0.01318173,-0.037633155,0.067312695,-0.028525641,-0.014032169,-0.027606687,0.11286664,0.011424004,-0.02576563,0.07343014,-0.04339943,0.00688919,0.048303477,0.00337267,0.09186178,0.03463457,-0.03868327,0.024878552,-0.039125223,-0.005723275,-0.0039689434,0.04608612,-0.024452161,-0.06469545,-0.07920363,-0.07495876,-0.04030643,0.0058799465,0.01639437,-0.009972202,0.008986578,-0.04838354,0.03312668,-0.05024643,-0.07725717,-0.08343609,-0.049239486,0.010305727,0.042872466,0.070076056,0.05691089,0.026157007,0.11740912,0.052448023,-0.0037688543,-0.008262321,0.021438897,0.003316658,0.013798982,-0.09354643,0.027438883,-0.053737924,0.01351795,-0.038837574,0.003600124,-0.03097738,-0.016486166,-0.094670795,5.6370413e-33,0.108123496,0.003573972,0.044833384,-0.03228082,0.02703554,0.0002849568,-0.07585551,0.053201318,-0.09337111,-0.0074037146,-0.004517597,-0.0757439,0.0737468,-0.010345011,-0.026715735,0.037580926,-0.03194693,-0.056376044,0.008776694,-0.07606374,-0.03731661,0.03375559,-0.022052972,-0.0056094415,0.031424124,0.0318268,-0.024920395,-0.00037054505,0.08696763,0.009705475,-0.014408108,-0.062282663,-0.100485936,-0.04648651,0.06751144,-0.062666535,0.0065735164,-0.10557331,-0.02067163,-0.008080721,-0.0614511,0.03298958,-0.029466804,-0.075454615,0.08638845,-0.0009016491,-0.024805078,0.025131118,0.048396785,0.04094952,-0.0009788042,-0.11090009,0.0878479,-0.022554252,-0.026297428,-0.053895995,-0.060875352,-0.050574146,-0.006831681,0.022360865,0.06539021,0.010989541,-0.013433093,-0.062839486,0.03809602,0.015621003,-0.001129998,-0.013269655,0.05453196,0.01225015,0.028724505,-0.061616983,0.02851014,-0.008292763,-0.10402607,-0.04192717,0.008461105,-0.034432005,0.035507202,0.005101267,-0.05129519,-0.015829435,0.035930507,-0.086038366,-0.005731391,-0.013497563,0.013609482,-0.04502463,-0.038042262,0.010930185,0.0382179,-0.00970993,-0.04653838,-0.023217795,-0.014602202,-5.5087717e-33,0.12211291,-0.051232044,0.03428124,-0.06752856,-0.08745506,0.015431984,0.009490306,0.0031941393,0.016205922,-0.049196392,0.09197412,-0.015881408,0.037758287,-0.06439809,0.064947814,0.026555961,-0.0073797037,0.055321194,0.026617005,0.023149615,0.017714847,-0.013233946,0.045440532,0.029598162,0.08216927,0.017858662,-0.011949505,0.04911795,-0.0066185314,0.044039097,-0.032928254,-0.01599235,-0.13405032,-0.04093685,-0.022658378,-0.011903076,0.0005233989,0.008675864,0.012178574,-0.09583571,0.011015173,0.046888523,0.0034572305,0.12968281,0.036479555,0.055815507,0.010581431,0.049072575,0.0047711236,-0.018271461,-0.006849569,-0.04361142,-0.013965882,0.014176262,0.00068602624,0.05294541,-0.049125507,-0.039515417,-0.036606018,0.0053217374,-0.03355293,-0.11103739,0.01288649,0.003123441,0.0050815684,0.09226249,0.014382981,0.08235239,0.10414107,-0.075631805,0.00043520515,0.012270695,0.08105288,0.03457866,-0.04387753,-0.040945146,-0.055326305,-0.0008061872,0.00423111,-0.010136366,0.04396671,0.055849012,-0.051003523,-0.093564436,0.10425059,-0.0008465305,0.043930985,0.1253098,0.016724769,0.040505692,-0.07783575,0.022256417,0.02428981,-0.011836255,-0.0029836087,-3.3350695e-08,0.06851033,-0.0700571,0.07100397,-0.073003754,0.038564466,0.0574073,-0.010719657,0.060180847,-0.065534644,0.060129378,0.042579856,0.018325672,-0.04475027,-0.0545307,0.084434696,0.08442899,-0.11398226,-0.027636826,-0.02306343,0.0067191864,-0.018511582,-0.021671979,-0.100833744,0.15325513,0.0025612456,-0.030760316,0.05299802,-0.009268197,-0.07424655,-0.014825639,0.053083815,-0.018783383,-0.0023285933,0.028410733,-0.035955925,-0.011780264,-0.041995298,0.01144309,-0.04242544,-0.00039937653,-0.014130707,0.04860291,-0.03689234,0.005380522,-0.022697313,0.019384895,-0.033932745,0.08259799,-0.056216955,0.060765825,0.02036398,-0.04741812,0.0071517406,0.021529658,-0.130314,-0.03949117,-0.020125821,-0.04830867,-0.006935219,0.028250732,-0.031509496,-0.03426535,0.113482155,-0.023901153 +1.8.3.6,A flavoprotein (FAD). In contrast to mammalian EC 1.8.3.5 (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine. ,384,0.99999994,-0.016776873,-0.043783985,-0.051899806,0.022000056,0.1624557,0.108484395,-0.10358866,0.0385702,0.08956602,-0.008230102,0.0667301,0.019454816,-0.0627634,-0.00080332434,-0.0315228,0.03209531,-0.034139022,0.039758373,-0.08257417,0.00023695371,-0.041287016,0.0085925525,-0.0034605039,0.038949907,0.019946497,-0.101212084,0.029323354,-0.04583422,-0.097999685,0.011620169,0.0061094,-0.009112229,0.08070011,0.04173216,-0.038353436,0.043747522,0.041672546,-0.07162105,0.04410599,0.04547064,-0.03737381,-0.04430327,0.06206973,0.011322685,-0.008785384,0.019196628,-0.03464743,0.0072092484,-0.004498418,0.030166477,0.013230227,-0.054728106,-0.041920368,-0.021476315,-0.01667624,0.042036135,-0.032567687,-0.042576056,0.015793592,0.051016603,0.039946858,-0.0369256,0.019828683,-0.021002484,-0.0023593958,-0.06453224,0.0014230593,-0.059606414,0.051455483,-0.08282401,0.022279918,-0.022254411,-0.07254869,0.08299193,-0.044858247,0.040385034,-0.096628144,0.016147504,-0.0014157007,-0.03505138,0.09410559,-0.03614772,0.053536274,0.05233804,0.07587724,-0.030270914,-0.06367868,0.10130729,-0.0012108535,0.052556697,0.011183568,-0.0075704195,-0.007214144,0.009694597,-0.059082743,0.025536139,0.08682382,-0.040938497,-0.0800068,-0.056279942,0.028881315,0.0038225472,0.0133687,0.001764271,-0.0032048842,-0.03627084,-0.051156025,0.026325557,-0.0888186,-0.08596879,0.055263348,0.0027097398,0.040227957,-0.0563892,-0.01494139,-0.040943585,0.008302677,-0.023573367,-0.07603586,0.034607623,-0.049161103,0.087842144,0.0231999,0.103758216,0.053164247,-0.0428275,-0.054275904,3.1662517e-33,0.06758102,0.008348105,-0.025851583,0.038581643,-0.013401421,-0.0072449595,-0.006377586,0.069490105,0.022108562,-0.01767451,-0.062416993,0.027095018,0.0052886535,-0.081290424,-0.0015824537,0.045441672,-0.06442105,-0.12517868,0.10759986,-0.09036993,0.0022569413,-0.00087503775,0.02985629,0.010155717,0.039124176,-0.034763034,-0.0007906928,-0.06098598,0.019182308,0.031930048,-0.08022822,-0.080216356,-0.02130445,-0.033861168,-0.009180302,0.006017981,-0.104786284,-0.09532822,-0.05557205,0.030576205,0.0014722849,-0.0009473945,-0.01591254,-0.032296572,-0.005749278,0.03364595,-0.07592483,0.090038694,-0.017509189,0.066622,0.057767484,-0.055070877,0.020525372,0.06970516,-0.103975296,-0.018928178,-0.025355577,0.00010026468,-0.05572149,0.08544341,0.009866197,0.074454024,-0.0069733965,0.022008624,-0.056140613,-0.003486459,-0.051528156,-0.099597506,-0.026985902,0.09753473,0.06932285,-0.079377174,0.14234307,0.016728748,0.02508404,-0.03413791,-0.051096663,0.0382542,0.03267292,0.036663022,-0.02417019,-0.022912562,-0.024938216,0.03814762,-0.019561091,0.005492051,0.025928987,0.024887616,-0.018486366,0.015298203,0.05058778,-0.07373217,0.06082919,0.026880413,0.054184955,-2.8459717e-33,0.013897001,-0.09584893,0.010471656,-0.03280865,0.05077266,0.042476628,-0.0004755551,-0.044430356,-0.020388069,-0.042309888,0.057728216,-0.03353599,-0.053797778,0.00550156,0.04529684,-0.026435472,-0.011241963,0.018197002,0.028725307,0.0298443,-0.08331905,-0.06623733,0.06970291,0.09106149,0.11929022,-0.008936834,0.017462637,-0.0056467503,-0.04526189,0.0596157,-0.005781265,0.039408386,-0.018798407,-0.03271754,-0.042665593,0.033209085,-0.055824533,0.032669146,0.020757092,0.042141356,-0.038971253,0.011067291,-0.035822134,0.06666064,0.01929752,0.08614555,-0.04989689,0.029075986,0.056309346,-0.07387177,-0.025833461,0.026629774,-0.018067235,0.02405093,-0.00071881345,0.048419088,0.028075017,0.009166809,0.012642744,-0.030475736,-0.046324383,-0.070991985,-0.026663478,-0.0067993365,0.066127636,0.06746418,0.021394195,0.07646768,0.022700882,0.025779271,0.10559814,-0.016784694,0.06744821,0.09107001,0.00029325119,-0.027156599,0.010347364,0.042499382,0.0031428733,0.032734282,0.0027911738,-0.0037005353,-0.00466695,0.037424337,-0.030923221,-0.12806879,0.04726242,0.056458883,-0.008359026,0.009043383,-0.0002446545,0.06745328,0.026265737,-0.05061754,0.10074311,-3.2128586e-08,0.008133775,-0.052587893,-0.021865686,-0.06640647,0.057747375,0.031671092,0.03381881,0.115678996,-0.012652995,-0.013207718,-0.017126506,0.07263511,0.0115692215,0.025873605,0.06806855,-0.048521668,0.03565798,0.064559914,0.009326521,0.05456643,-0.036849562,0.040692583,-0.110887274,-0.056797612,-0.0991282,-0.0062486334,0.0038006005,0.0034587148,0.036667235,-0.03229611,0.090349056,-0.03802604,-0.0127178505,0.019374315,-0.112308726,0.026513953,0.03135338,-0.050818898,-0.041056346,0.022754489,-0.118325844,0.038396135,-0.08678196,0.02343459,-0.019109374,-0.08869847,0.07366166,0.037424088,-0.0061099376,0.025769867,0.025775509,-0.04354375,-0.01277956,-0.04378335,-0.021885492,-0.055825274,0.01583419,-0.07593932,-0.05188091,-0.07874802,-0.009830221,0.015654845,0.12182795,0.01657011 +1.8.5.4,"Contains FAD. Ubiquinone, plastoquinone or menaquinone can act as acceptor in different species. In some organisms the enzyme catalyses the formation of sulfur globules. It repeats the catalytic cycle without releasing the product, producing a polysulfide of up to 10 sulfur atoms. The reaction stops when the maximum length of the polysulfide that can be accommodated in the sulfide oxidation pocket is achieved. The enzyme also plays an important role in anoxygenic bacterial photosynthesis. cf. EC 1.8.5.8, sulfide quinone oxidoreductase.",384,1.0,-0.07147564,-0.029724682,-0.07911198,-0.026493298,0.0051620007,0.008214238,-0.012169736,0.025725245,0.001894516,-0.033707533,0.023510769,0.03737531,0.0019865946,0.012223313,-0.0380967,0.1244223,-0.10519964,0.009972216,-0.00038915811,-0.040277526,0.08886382,-0.05672892,-0.05972118,-0.05070427,-0.014758527,0.04393458,-0.015441978,-0.0029459002,-0.088656634,-0.05065803,0.038384054,-0.05627456,0.0044522574,-0.035293214,0.00057258393,0.108802855,-0.041469507,-0.04460672,-0.018452745,0.008503739,-0.0020101485,-0.030459508,-0.028732698,0.02682758,0.029388038,0.00074182486,0.014854637,0.051358663,0.048974,-0.06308968,-0.050214197,-0.0532005,-0.052298095,0.09520789,0.06859682,-0.030063327,-0.054391894,0.038860127,0.015674217,-0.07142426,-0.008521426,-0.020626405,-0.007050405,-0.025961403,0.048446104,0.005735427,-0.041643437,-0.05736775,-0.025624735,0.009291618,0.0082733175,-0.034165476,-0.06505659,0.0120360525,-0.044979494,0.067157365,-0.0602075,-0.043238807,0.05798982,0.028336551,-0.018919561,0.0047522793,0.032999996,0.10832485,0.047057945,-0.031700745,0.03984792,-0.003866469,-0.00017399802,0.035323016,-0.016101984,-0.02659714,0.00021434642,-0.04125246,-0.051032826,0.053974573,0.018013883,0.094087735,0.002630199,-0.055901315,0.033075333,-0.007341111,-0.0999054,-0.12878671,-0.04695686,0.01795804,0.0042813458,0.122091144,0.016233891,-0.0054695467,-0.06370049,0.028884325,-0.041978598,-0.012483841,-0.021593073,0.05385244,0.114917316,-0.022191834,-0.15768003,-0.0029146213,-0.05461371,0.056454606,0.038479455,0.0017695249,-0.012165059,-0.04749497,-0.11286521,3.133535e-33,0.062011365,0.041000023,0.056177385,-0.023961607,-0.04971011,-0.002927685,-0.10062371,0.029922988,-0.014817712,-0.03497401,-0.08253777,-0.04617585,-0.013160538,0.04096981,0.028071865,0.002113574,0.020178447,-0.003816175,0.06151197,-0.02601494,-0.04152264,-0.02712026,-0.025048722,-0.04348679,-0.025850542,0.06527721,0.029545136,-0.01274728,-0.017876348,0.008385164,0.050181244,-0.10043238,-0.037794426,0.056401197,0.032196306,-0.0138777625,-0.0953143,0.013009319,-0.029827768,0.012108794,-0.0110188145,0.03162751,-0.01563249,-0.0066501754,0.12068504,-0.036413398,-0.03006907,0.09775194,0.04774897,0.04963805,0.015751513,0.037070666,0.07272716,0.0061226143,-0.052285783,0.03321704,0.042158555,-0.0027201718,0.012655904,0.012181578,0.039969523,0.09893786,-0.01544247,0.008876245,-0.065829,0.057765655,-0.026991218,0.026718901,-0.046392415,0.11425183,-0.020042479,-0.05837597,-0.01569985,0.007886456,0.0243287,-0.030010372,-0.00036835944,-0.022739468,0.06605077,-0.017152507,-0.027143707,-0.07476173,-0.007802192,-0.04970111,-0.11822057,-0.002234819,-0.0011933575,-0.04864089,-0.031450864,0.05449027,0.06200538,-0.08845495,-0.041245267,-0.013555187,0.032165878,-3.3979905e-33,0.10057759,-0.08457089,0.06055966,-0.120456874,0.028714664,0.066315144,-0.01513025,-0.0026191687,0.027050044,0.02198748,0.046802882,0.007929874,0.04640691,-0.009264425,-0.025351893,0.007131011,0.05208746,0.048520368,-0.0070553394,-0.071540765,0.025107125,0.09707904,0.06708113,0.009533791,-0.0067991037,0.030439213,-0.0015564198,0.038414374,0.1467549,0.040345673,-0.0034133361,-0.009482478,-0.05160176,-0.053777628,0.0183588,0.018294115,-0.05566085,0.05672159,0.07234689,0.047659867,0.03689653,-0.05647686,0.0002760693,0.09285986,0.049743615,0.0638355,-0.08314401,0.05055635,0.01422758,-0.055260587,0.054627813,0.047492735,-0.044569675,0.040522564,0.101374544,0.05585054,-0.013339291,-0.049694367,-0.0042045694,-0.030882264,-0.051199514,-0.109050885,0.021355506,-0.00482069,-0.0367989,0.08156092,-0.00828951,0.047780335,-0.02283542,0.032001507,0.09437287,-0.054521676,-0.042079214,0.013283112,-0.032341436,-0.0038780235,-0.06249267,-0.001980979,0.034628928,0.030629504,-0.02382148,0.021704141,-0.0022386522,-0.01401118,0.025373835,-0.12470396,0.0055523748,0.06796036,-0.026182614,0.042856626,-0.023629267,0.073793076,-0.012400385,0.041527174,0.03188493,-4.072838e-08,-0.027057955,-0.050568298,0.13656797,0.011645345,0.01651128,0.017712772,-0.024162924,0.040720966,0.05453539,0.01667947,0.02380105,0.06761484,0.032903813,-0.051003996,0.06817022,0.013926341,0.057984065,-0.05044682,-0.007826742,-0.04120507,-0.08682994,-0.022131417,-0.10142982,0.0098169185,-0.02219726,-0.057040703,0.076140806,-0.025665844,-0.07645061,0.0052749305,0.06704714,0.04773154,-0.03404446,-0.054911096,-0.076228425,0.04418754,-0.0059284572,-0.03128321,0.04139115,-0.059861295,-0.052766517,0.00647126,-0.029500563,0.07761108,0.04498205,0.013290367,0.031719197,0.007004952,-0.09232464,0.052090187,0.056066144,-0.04151616,0.03729394,-0.09739023,-0.095904596,0.04574889,0.040185142,-0.06508436,0.021275423,-0.036756672,0.015538869,-0.015677737,0.15491861,0.038143262 +1.10.3.9,"Contains chlorophyll a, beta-carotene, pheophytin, plastoquinone, a Mn4Ca cluster, heme and non-heme iron. Four successive photoreactions, resulting in a storage of four positive charges, are required to oxidize two water molecules to one oxygen molecule.",384,0.99999994,-0.052636765,0.0021282653,-0.063640445,0.06852716,0.11264266,0.0026181976,0.06577026,-0.0021968852,0.00741963,0.005718738,0.07698454,-0.08197109,0.0023688606,0.07766757,-0.07178807,0.068789825,-0.14488336,0.014504523,-0.04416194,0.014215016,0.013522833,-0.041845616,0.038805846,-0.041610982,0.023890117,0.054992523,0.006252503,0.013975061,-0.009548064,-0.08311199,0.020735227,-0.0017559476,0.09438015,-0.06174204,0.09801465,0.08253849,0.019822393,-0.11653466,-0.06731293,0.07290722,-0.035721224,-0.0012196576,-0.002552137,-0.0051750583,-0.039616607,-0.0048156376,0.059080034,-0.022959782,-0.030788925,-0.00035392406,-0.012453075,-0.050967358,-0.12608923,0.072035685,-0.03350828,-0.012518259,-0.039721135,0.019499024,0.029337598,-0.03767606,0.052404363,-0.020063639,-0.04379985,-0.010856527,0.0012054363,0.022617832,0.0066015194,-0.027952947,0.010984114,-0.05474655,-0.028519772,0.017271362,-0.044149548,-0.031356327,-0.106031835,0.011737802,0.09481395,-0.056904137,0.037977047,-0.011116317,0.0041679777,-0.019640315,0.020923942,0.11905643,0.0908064,0.0902337,-0.05393664,-0.063311,-0.04707259,-0.048606236,-0.06416368,0.07374026,-0.03018987,-0.0438726,-0.04578251,0.076155946,0.029989561,-0.02950812,0.040917747,0.03191483,0.03138715,0.05017048,-0.060575288,-0.09357119,0.019395687,-0.05812449,0.020494116,0.09984533,0.020729873,-0.031504698,0.007869775,0.048216384,-0.0035301822,-0.004905325,0.015734296,0.049445905,0.022657158,-0.012642008,-0.067631274,0.03843329,0.00045273136,0.0003811753,-0.030834354,-0.028503869,-0.04202093,-0.04585919,-0.023425959,5.3226505e-33,0.10315702,0.0027771138,0.086945035,0.007878255,-0.052954752,-0.027600272,-0.061369274,-0.02010204,-0.02766671,-0.051303122,-0.077636436,-0.012819951,0.050142277,0.03713916,0.027446568,-0.094352864,-0.003855564,0.011402053,0.046410374,0.013085714,-0.016572153,0.08462468,-0.0032666745,0.0022125565,0.023556968,0.04830852,0.055310708,-0.02612272,0.046326693,-0.023748081,0.059300788,0.05844339,-0.07416834,0.03863885,0.035148446,0.019314224,-0.05953197,-0.0145674255,-0.036491446,0.03191771,-0.04940369,0.097842835,-0.038349707,-0.0053003826,0.07000053,-0.05906835,-0.06741373,0.010569853,0.013400557,0.050266877,-0.045953784,0.026796294,0.009715208,0.04996911,-0.05234721,0.0012500987,-0.02983148,-0.022962894,0.0315311,0.026001405,0.00486879,0.050428923,-0.037906412,0.0064883907,0.031473763,0.07773147,-0.06819429,-0.0075955945,-0.01083815,-0.026689442,-0.049448304,-0.0049522235,0.020238137,-0.037477635,0.05072754,0.0014684792,0.0017485262,-0.009208056,-0.035014745,-0.023082115,-0.0060036336,-0.07811422,0.050733432,-0.041324098,-0.109805405,-0.034876134,0.051556624,-0.02768588,-0.008449322,-0.023433652,0.030775404,-0.05263314,-0.0013609569,-0.18353069,-0.027135255,-4.7332092e-33,0.10777168,-0.047707215,-0.03428633,-0.086592324,-0.008978203,0.025400726,-0.07593795,-0.079935126,-0.017021865,0.030596156,0.06226907,0.021371292,-0.02321705,-0.048373323,-0.031085955,0.012374912,0.04788368,0.051016912,0.089801475,0.03051241,-0.0063439743,0.040107932,0.09425001,0.071803115,0.075096585,0.06083787,-0.017362183,-0.08833582,0.0792848,-0.013955335,-0.047731675,-0.03112009,0.040139176,0.018027646,-0.012449114,-0.051444188,-0.007726896,0.052203503,0.004662796,0.0695302,0.0375762,-0.083995745,0.0507999,0.097645305,-0.012823387,0.021349333,-0.1274958,0.0025497607,-0.044632267,0.020738596,-0.055675026,-0.0044985353,-0.11744658,0.028125972,0.0847363,0.008248423,0.027440015,0.00083977135,0.014922857,-0.014204341,0.034581013,-0.07068373,0.02703754,-0.007947648,0.045673713,0.041999895,0.013037476,0.06414948,0.0066602896,-0.0222681,0.028196095,0.009240813,0.12902096,-0.027343702,0.00059133384,-0.06256378,-0.041018713,-0.0065674614,-0.026189405,-0.0065017357,7.804372e-05,0.0053560697,0.00028974222,-0.04099896,0.018402219,-0.060850754,0.028634196,0.003866688,0.015246989,-0.0025554344,0.007627949,0.030987164,0.068722025,0.09920728,0.08341041,-4.0343632e-08,-0.016109504,-0.027793972,0.05098914,-0.03812511,-0.03578768,0.013842782,0.0730373,0.0824612,0.0038928068,-0.032774467,0.064464875,0.085395016,0.0621363,-0.10886174,0.05154575,0.008455082,0.013709144,-0.022743637,-0.03251281,0.019988498,-0.09141417,-0.020016767,-0.07515671,0.071385354,-0.008704862,-0.015281486,0.08227336,-0.05066137,0.03126191,-0.054660834,0.056202684,0.040912908,0.084411696,-0.07426417,-0.09495457,0.013217926,-0.022352958,-0.011646653,-0.09013362,0.011859427,-0.106037445,0.009477083,-0.07207998,0.027016254,0.061622776,-0.00043664777,0.03675506,0.014762153,-0.02875952,0.03932125,-0.05251684,0.01200622,-0.0017356443,-0.0146992225,-0.12739512,0.07531886,0.012434106,-0.008128446,-0.0016669297,-0.04774764,0.030816343,-0.031045398,0.09827359,0.024716673 +1.10.3.10,"Contains a dinuclear centre comprising two hemes, or heme and copper. This terminal oxidase enzyme generates proton motive force by two mechanisms: (1) transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water, and (2) active pumping of protons across the membrane. The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) depends on the enzyme; for example, for the bo3 oxidase it is 2, while for the bd-II oxidase it is 1. cf. EC 1.10.3.14, ubiquinol oxidase (electrogenic, non H+-transporting).",384,1.0,-0.067311145,-0.021427598,-0.10529447,0.061333645,0.121110156,0.012189838,0.00050194294,0.032096464,0.01181941,-0.06973108,0.0029127037,-0.0567645,-0.020459848,-0.01615999,-0.031378098,0.016033292,-0.027232423,-0.0317156,-0.0876003,-0.06650063,0.06281696,-0.028055301,0.10219169,-0.021874797,-0.06855153,-0.040483125,0.06783564,0.028668016,0.0019762577,-0.073944464,0.08453237,-0.062559396,0.016058968,-0.06257114,-0.0064860852,0.025962796,-0.0025957439,-0.043491483,0.003020925,0.01813454,0.046717755,-0.039596923,-0.0036497738,0.039840825,0.014211738,0.015959425,0.02325978,-0.016007358,0.0036693085,0.008871793,0.012703852,-0.06196749,-0.033092313,-0.0062421546,-0.000481031,0.041509394,-0.013533934,0.055314966,0.026819797,-0.035409614,0.03698963,0.045294426,0.021759244,0.000724129,0.015580495,-0.056320567,0.025567666,-0.04341337,-0.0059360787,-0.060009856,-0.0045446143,-0.10198287,-0.099927194,-0.06212163,-0.025464928,0.020176828,-0.0007217231,-0.03104272,0.017415723,-0.025399415,-0.00662889,-0.011913055,0.013327441,0.104375534,0.014996737,0.011178281,0.04402237,-0.109502956,-0.01769044,0.02514762,-0.008941796,-0.015410398,-0.06788996,0.013828006,-0.10921813,0.027355483,0.06506514,0.06309626,-0.030900393,0.0025489922,-0.011534329,0.14746626,-0.03743031,-0.056602154,-0.031503633,-0.005139611,-0.009164179,0.085977726,0.104621924,0.041479144,0.059418913,-0.0037395353,0.010547623,0.0062867072,0.027786162,0.08158632,-0.013229524,0.013932098,0.009150081,0.005534902,0.045005657,-0.0060465843,0.017845543,0.014521389,-0.03295668,-0.10120742,-0.10007714,2.7384337e-33,0.05815205,-0.05648078,-0.0052846186,-0.033272885,-0.049127392,-0.054072034,-0.08767913,0.03409698,-0.02990426,0.053797018,-0.09153641,-0.05043526,0.07457662,0.023799986,0.014581223,-0.081067406,-0.06267887,-0.035150908,-0.006487979,0.072966516,0.03957678,0.00949603,-0.017699044,-0.021897763,0.10513351,-0.049602885,-0.0326434,0.019788079,0.049990274,-0.0043607187,0.03656386,-0.056486208,-0.050843287,-0.009030492,-0.073432826,0.006094064,-0.049827576,0.0019943854,0.021193115,0.022412883,0.012198003,0.025108052,0.02194257,-0.04333113,0.10517081,-0.056578223,-0.031902872,0.049258284,0.034092847,0.051445507,0.00052199996,-0.046265166,0.1642365,0.02600675,0.024392111,-0.04123531,-0.041076683,0.06123357,0.06960266,0.08917352,0.040683504,0.090848394,-0.05374749,0.035546113,0.03466948,0.063047364,-0.033825375,-0.023992546,-0.00079351605,0.06534266,-0.08317956,0.018726198,0.014882951,-0.06829309,0.0033870763,-0.04010044,-0.06261905,-0.014590746,0.08128178,0.017382609,-0.031554215,0.025493009,0.05654432,0.001972892,-0.0184622,-0.0040802555,-0.017233027,-0.014874641,-0.039720386,0.013683376,0.0570708,-0.0706389,0.009852543,-0.090011954,0.04103675,-3.719067e-33,0.06008249,0.01290057,-0.037527155,-0.08519194,0.037907146,0.025265422,-0.0111422,-0.035808776,0.0071873665,-0.038477276,0.044113822,0.021673067,0.0040132124,-0.015698282,0.018866904,-0.032981526,-0.093442306,0.081279315,0.027584545,-0.002163869,0.052228153,0.108387165,0.030381715,-0.009779609,0.08673872,-0.022711532,-0.06035778,-0.023962505,0.057385575,0.08564251,-0.06328831,0.052597065,-0.027653607,0.041711226,-0.09244376,0.04655428,-0.101694904,0.039299782,0.07014857,0.07825011,-0.045768645,0.00997775,0.04473413,0.04041601,0.0044195545,0.12380765,-0.1490717,0.027982896,0.0005114389,-0.015467342,0.050515983,0.022703651,-0.07992474,-0.019638475,0.03962625,-0.0113266455,-0.0105749415,-0.0023043405,-0.019678708,-0.08021999,-0.030797614,0.008735578,0.046817772,1.2014604e-05,-0.047892127,0.062667586,0.02145862,0.10851987,0.014951108,-0.050987955,0.027883863,0.053699534,0.038936876,0.0075438437,-0.019585777,-0.06020629,-0.021586582,-0.0012218346,-0.011300974,0.008822743,-0.024447188,0.060686827,0.0075291796,-0.08865413,0.010602571,-0.041596092,-0.05035489,0.05550659,0.017965276,0.01651558,-0.004688749,-0.025490306,0.041354217,0.07368949,0.03129079,-4.8781235e-08,0.024216779,-0.06656379,0.045158993,-0.033444826,0.046382073,0.031030297,-0.002781142,0.010858993,0.031817008,-0.037019465,-0.015124589,0.11257025,-0.03447867,-0.0032577547,0.072305046,0.060694877,0.022492861,0.03773408,-0.020249104,-0.08662536,-0.025782516,-0.015238302,-0.16612652,0.032612633,0.07011103,-0.03989864,0.021479864,-0.025676744,-0.035352398,-0.03190101,0.05835588,0.011758875,-0.023560029,0.0010586609,-0.023475014,0.03681605,-0.064481266,0.014362186,-0.04612609,0.010987216,-0.05038323,-0.068289116,-0.04510905,-0.011298783,0.023519704,0.024040839,-0.0066941767,0.054424517,-0.04298427,-0.03735686,0.015241759,-0.09923478,0.04218008,-0.076202884,-0.08423044,0.111925475,-0.04054474,-0.089272656,-0.006249927,-0.07851766,0.06523393,0.053144995,0.15939951,-0.0051979832 +1.10.3.11,"The enzyme, described from the mitochondria of plants and some fungi and protists, is an alternative terminal oxidase that is not sensitive to cyanide inhibition and does not generate a proton motive force. Unlike the electrogenic terminal oxidases that contain hemes (cf. EC 7.1.1.3 and EC 7.1.1.7), this enzyme contains a dinuclear non-heme iron complex. The function of this oxidase is believed to be dissipating excess reducing power, minimizing oxidative stress, and optimizing photosynthesis in response to changing conditions.",384,1.0,-0.059581023,0.015212585,-0.100478314,0.095234215,0.16584325,-0.0028996626,-0.04759923,0.047260348,0.030018017,0.0046736323,0.050589185,-0.036150567,-0.035441924,-0.016806396,-0.06297689,0.026384104,-0.041746713,0.04291166,-0.05693713,-0.047673278,0.010473583,0.01956597,0.0016294977,-0.022703452,-0.019568503,-0.063249595,0.0093247965,0.004710101,-0.06372563,-0.085398525,-0.02239162,-0.0335254,0.040349852,0.0172924,0.010617971,0.07558667,0.0062565915,-0.117810175,-0.024381472,-0.015757529,0.013952948,-0.003722358,-0.037174474,-0.035640083,-0.03369736,-0.010765411,0.044629365,-0.07440929,0.007385255,-0.0006565744,3.0214636e-05,-0.04089073,-0.03859675,-0.018251287,-0.0034105228,0.042500332,0.04093919,-0.011015507,-0.01626807,-0.004141445,0.0454434,-0.02378628,-0.03388234,-0.002305381,0.0068441783,-0.07006898,0.04511994,-0.047273397,-0.06232045,-0.08762461,-0.028318675,-0.084692806,-0.050677087,0.016137816,-0.039900117,0.02891476,-0.006860231,-0.07952758,0.012607546,0.038426075,0.0147586465,0.038418323,0.009746944,0.111020215,0.055466734,0.014044997,0.041573245,-0.037314985,0.018982762,0.04016927,0.0021296828,0.04013103,-0.037825625,0.017899506,-0.10955054,0.065800786,0.07818695,0.051072948,-0.05353002,-0.014630676,0.0055427267,0.10320683,-0.025547018,-0.09872316,-0.034359496,-0.011169452,-0.0043586297,0.040750943,0.058333483,0.026211765,0.05774709,0.01241754,-0.009256586,-0.013261307,-0.014021161,0.10354834,0.03213709,-0.026789531,-0.017809466,0.060637176,0.060013954,0.018145382,0.022737259,0.033099443,-0.024550112,-0.040852632,-0.08773901,2.0175076e-33,0.032600157,-0.00037022936,-0.0011245757,-0.037896607,0.021485096,-0.026833521,-0.101760365,-2.5999983e-05,-0.015730267,0.015297373,-0.11294015,-0.016719587,0.05506432,-0.061611243,0.015380087,-0.042130716,-0.038620614,-0.037788086,0.037939712,0.07662448,0.042364728,-0.030623205,-0.034262393,-0.0074631716,0.033680428,0.034082398,0.04371167,-0.008738474,0.06413739,-0.0143386545,0.0035914155,-0.09952559,-0.029594582,0.0061298274,0.05119306,-0.0443563,-0.023113435,-0.017579691,-0.029824462,0.044313945,-0.0404098,0.039881498,0.013286435,-0.03274754,0.09561258,-0.07639532,-0.027198741,0.04458221,-0.007687694,0.095265634,0.031046415,-0.02587889,0.12154771,0.029267687,-0.010669082,-0.0042275265,-0.052645024,0.012418429,0.033547014,0.036576796,0.029375846,0.0053924555,-0.040684998,0.059069548,0.062345397,0.081218526,-0.1077966,-0.044799272,-0.006062831,0.08932634,-0.0839343,-0.028472839,0.04015225,-0.034305833,0.06791511,-0.053696133,-0.07596088,0.07447761,0.024633702,0.011120571,0.02121809,0.021976149,0.005583315,-0.010025364,-0.026373817,-0.037592847,-0.013117861,0.060430847,-0.046300486,-0.02905231,0.124468744,-0.036333244,-0.025165567,-0.043866448,0.0044098017,-2.201106e-33,0.07052757,-0.057109214,-0.023177404,-0.10905014,-0.0008242743,0.06334958,-0.058544487,-0.06958572,-0.038470488,-0.042327475,0.0750658,-0.0022292242,-0.013192308,-0.05336426,0.02718885,-0.007312226,-0.022419417,0.05535726,-0.04753594,0.017034825,-0.017304728,0.12318119,0.024299018,-0.013286451,0.05323616,-0.035715796,-0.055167347,0.022281582,0.031464208,0.045149427,-0.027835438,0.029853612,-0.021825066,-0.01164842,0.016641576,0.029990116,-0.08208037,-0.002052643,0.07096899,0.08865142,-0.02010063,-0.017591115,0.05391979,0.046566814,0.03250547,0.08587838,-0.17159915,0.015807075,0.029358631,-0.033182837,0.033987805,0.01928888,-0.06604963,-0.010644161,0.08332768,-0.03308262,-0.020683162,0.029345816,0.021533886,-0.0030362105,-0.011910815,-0.050638992,0.054051332,0.04163892,-0.019395245,0.07185473,-0.05126269,0.08431149,0.031512722,0.038644806,0.084087305,0.044518176,0.048158426,0.024854664,-0.021439824,-0.063323654,0.03726567,0.043651227,-0.037470452,0.011525718,-0.021224117,0.014239363,-0.014009568,-0.109816976,-0.0034954578,-0.09460355,-0.05739195,0.070185184,-0.010127105,0.0024369266,-0.016927712,-0.042010058,-0.0037232228,0.04680145,0.041213848,-4.602155e-08,-0.037032682,-0.10121198,0.031860627,-0.069850765,0.0059232875,0.01872617,0.04364148,-0.038069274,0.08011139,0.0018473772,0.09543396,0.121407144,0.031457048,-0.0045211576,0.0706345,0.04775142,0.07853657,0.06421449,0.018622195,0.06772684,-0.028800584,-0.014326832,-0.1946375,0.028293082,0.0411694,-0.0580179,0.047026217,-0.018393246,-0.00490595,-0.054098126,0.036554225,0.039858878,0.0336307,0.0017186454,-0.10681586,0.047477387,-0.0015531059,0.0024243991,-0.06397893,0.019020239,-0.014300894,-0.03593367,-0.11287,-0.010161348,-0.020975387,0.01940594,0.06562273,0.021776427,0.0043400093,0.028383164,0.016193528,-0.010229471,0.004100805,-0.053250223,-0.103819445,0.04552419,0.07189044,-0.060627896,-0.0526098,-0.032454737,0.06905526,0.0019184995,0.15162046,0.008291341 +1.10.3.12,"Cytochrome aa3-600, one of the principal respiratory oxidases from Bacillus subtilis, is a member of the heme-copper superfamily of oxygen reductases, and is a close homologue of the cytochrome bo3 ubiquinol oxidase from Escherichia coli, but uses menaquinol instead of ubiquinol as a substrate.The enzyme also pumps protons across the membrane bilayer, generating a proton motive force.",384,1.0,-0.124455884,-0.024519974,-0.12508681,0.003930614,0.0013990733,0.0044229575,-0.021120004,0.022569466,0.009669056,-0.057879876,0.012168611,-0.042629655,0.028529951,0.025233228,-0.028986532,0.040033054,-0.061574556,-0.017906077,-0.04424927,-0.020109069,0.035140216,0.08210439,0.048593737,-0.010604252,-0.01949834,-0.038030174,0.051469173,-0.0051430883,-0.072150305,-0.029201277,0.023919007,-0.043115534,0.0698301,-0.064206816,0.06634996,0.055441737,-0.034113176,-0.015781775,0.016713332,-0.012120142,0.006103167,0.051745255,-0.002271776,0.10091677,-0.011113673,0.016344432,0.005942628,0.016661556,0.09358399,-0.019447032,0.0044961236,-0.038671955,-0.03590066,0.058973607,0.04707661,0.025851216,-0.07448205,-0.055034135,0.025934683,-0.041458063,-0.017372139,0.028737642,0.042094246,0.02033043,0.023125453,-0.010191402,-0.047169697,-0.0652068,-0.022527255,-0.03265409,-0.062153533,-0.090107694,-0.07829227,-0.006269814,-0.068516225,0.08703589,0.036039818,-0.064395584,0.021387959,-0.048908114,-0.002309907,-0.07612029,-0.0005756811,0.18598366,0.08030834,0.0001652528,0.026390674,-0.094375506,-0.063249886,0.0126775745,-0.029844856,-0.011861482,0.0016498445,-0.0486199,-0.06864941,-0.03963758,0.04412448,0.12765208,-0.027979257,-0.0020311542,0.044754073,0.12701122,0.0076177665,-0.07155397,-0.051198367,-0.050243344,0.016882814,0.109243825,0.08921263,-0.0018804793,0.0018845212,-0.02745665,-0.029570382,-0.08503518,0.026781479,0.033618737,0.021247935,-0.031257663,-0.10055002,0.023657057,-0.037326165,0.015520158,-0.010765331,-0.038993664,0.005278161,-0.09571641,-0.12240724,4.9065454e-33,0.025914328,0.016429992,0.024831057,0.02484883,-0.010354428,-0.044250097,-0.08087075,-0.02073795,-0.008738819,-0.015326676,-0.08185359,-0.0076958584,0.011587102,0.011351602,-0.0017820016,0.021359196,-0.058154978,-0.038148046,0.035616297,0.011091188,0.015208476,-0.029117564,0.008823768,-0.06883365,0.020757254,0.025902824,-0.013390782,-0.020638926,0.006972839,0.015796922,0.045370065,-0.047591846,-0.11465653,-0.034516033,-0.033359796,-0.0325262,-0.037687305,0.00065187336,-0.06966786,0.089842044,-0.056785714,0.035324797,-0.021123454,-0.03342828,0.1280092,-0.04603279,-0.06555592,0.1420387,0.015869899,0.07822387,0.039276544,-0.04727452,0.12912169,-0.013597302,-0.005897928,-0.0064387433,0.013136122,0.072413005,0.0048105763,0.044201892,0.08076597,0.090037234,-0.06633562,0.12072959,-0.020142026,0.06650549,-0.028883088,-0.027194194,-0.014328003,0.10282051,-0.03017147,0.032722615,0.01678781,-0.02636298,-0.04024468,0.028305264,-0.06352726,0.0021281403,0.05185704,0.025667617,0.015044518,-0.05897466,0.03069435,-0.023580732,-0.046381008,-0.035669927,0.013208531,0.0027122633,-0.06379534,0.051501665,0.08883472,-0.093544126,-0.016283682,-0.025708266,0.0071525713,-4.935378e-33,0.09445873,-0.052234072,0.014590795,-0.16589186,-0.012217175,0.026922017,0.018311275,0.008147895,0.0024061669,-0.006107896,0.048828132,0.023428096,0.026567912,0.0022277453,0.039631423,-0.046009842,-0.04355798,0.03766704,0.018452497,-0.00092737493,0.023601947,0.05699514,0.01593083,-0.035950176,0.02007501,0.025156546,-0.036878996,0.033342384,0.083658926,-0.029092444,-0.07399382,0.056642726,0.007952705,0.0040654154,-0.062371504,0.08013075,-0.016940787,0.028843576,0.055389,-0.0016016647,-0.012049867,0.064624146,-0.01601253,0.045481436,0.03346345,0.14896846,-0.09113926,-0.010172906,-0.034094617,-0.029056218,0.05025105,-0.027470607,-0.039492495,-0.008171082,0.061037757,0.0669777,-0.048588324,-0.029262157,-0.017388396,-0.046028044,-0.032676984,-0.0020964732,0.017154321,0.038519174,-0.080696926,0.092000514,0.04220272,0.048498534,0.0121416785,-0.044187944,0.03821549,-0.009823317,0.015827168,0.021812389,-0.018497149,-0.012219213,-0.0067811185,0.04537603,0.03998372,0.031773355,-0.056180283,0.004393992,-0.03564878,0.01217809,0.056068867,-0.04703575,-0.06467953,0.10411738,0.013894306,-0.04628365,-0.020726355,0.019973092,0.027276376,0.06025735,0.014137631,-3.9484284e-08,0.058596008,-0.03405556,0.11135263,-0.020789005,0.060702946,0.047855485,0.018404424,0.007474705,0.023706745,-0.011401975,0.056322385,0.07130882,0.00045357173,-0.037206136,0.076279655,0.060928266,0.0061736484,-0.054306805,0.03253454,-0.06173567,-0.0589967,0.013704172,-0.083685115,0.07393442,0.021164296,-0.08357284,-0.0071188947,-0.019499663,-0.0640539,-0.014078193,0.004618987,0.04584201,-0.039892886,-0.052473594,-0.063619815,-0.038652565,-0.028818779,-0.02536959,0.003460874,0.015903845,-0.03465151,-0.042265587,-0.065311976,0.0041927546,0.039656255,0.019673282,0.0060623963,0.052261684,-0.024997959,-0.04795955,-0.02774318,-0.06145611,0.037022468,-0.05503575,-0.099091366,0.08248049,0.028088065,-0.086267434,-0.026359988,-0.05024114,0.049981203,0.0028181104,0.12793443,0.0003311198 +1.11.1.21,"Differs from EC 1.11.1.7, peroxidase in having a relatively high catalase (EC 1.11.1.6) activity with H2O2 as donor, releasing O2; both activities use the same heme active site. In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.",384,1.0,0.0012097796,-0.029887764,-0.06554143,-0.016834259,0.02870855,-0.018092236,0.011681172,0.13226634,0.02816482,-0.023713557,0.016484205,0.0322043,0.018417621,0.020924859,-0.016429845,0.08252486,0.021236856,-0.00814347,-0.039605808,0.007989889,0.0031343175,0.057951275,0.040744685,-0.050175566,-0.014581473,0.0048405123,-0.012164937,0.04430946,0.024336597,-0.10084633,0.027640361,-0.04392907,0.036119424,-0.05733613,0.020158287,0.014541716,-0.032256912,-0.13772607,-0.01222233,0.033398587,0.053532816,-0.084512874,-0.055895835,-0.0064353365,-0.0103392955,-0.008574043,0.05415845,0.019644575,0.001227622,-0.026344191,0.015338689,-0.08003055,-0.0625655,0.00873312,-0.03578602,0.025921304,-0.034457497,0.039927717,0.029775105,-0.025286881,-0.035793804,0.02478442,0.06544392,0.064570166,0.03845045,-0.025806982,0.035397734,-0.0889833,-0.014571089,-0.08189819,0.014854038,-0.07298981,-0.036659375,0.020487716,-0.013813433,0.01005626,-0.015585464,-0.026899261,-0.023965383,0.042017587,-0.047264174,-0.035477307,-0.009533988,0.05505976,0.011947959,0.04487301,0.033764604,-0.025485605,-0.05132302,0.03661461,0.022014393,-0.0018080865,0.047465377,-0.0178192,-0.057837915,-0.019413376,0.101105504,0.08903385,-0.01666738,-0.041585255,0.005182519,0.07332159,-0.117016986,0.0039603855,-0.016355453,-0.0174231,0.02852944,-0.01310098,0.1098756,-0.049770024,0.0017710989,-0.041061915,0.010986929,0.015422861,0.0042481674,0.064113684,0.08911677,-0.013990129,0.018267194,0.002271852,-0.03038114,-0.11332594,0.04096049,-0.018169181,-0.04550224,6.0376766e-05,-0.07844404,2.7368368e-33,0.036379285,-0.048548173,0.022728844,0.0021090186,0.042892132,0.034433153,-0.16931687,-0.03405292,0.034140367,-0.059987616,-0.16682786,-0.0038018054,0.007066866,0.03384736,-0.05842473,-0.009878582,-0.038417827,0.0040738406,0.059489906,0.04645268,0.09616832,-0.0025550867,0.012052341,0.06068813,0.050329957,0.069515154,-0.00537337,-0.033589996,-0.010306652,-0.011485038,-0.0050854986,-0.04739641,-0.092163764,-0.068216704,-0.07947271,-0.012933506,-0.021884864,0.017353427,-0.011241448,0.006576515,-0.012254466,0.04592595,0.01867111,-0.059995767,0.13384025,-0.07495308,-0.059382126,0.08533371,0.015287385,0.032603655,0.014336084,-0.05528539,0.03791332,-0.040504575,0.012265735,-0.04002996,-0.0016276197,0.090008385,0.08542893,0.12734215,0.06656327,0.103832185,-0.012507655,0.0811933,0.015956167,0.07092996,-0.04088213,0.01200454,0.051927898,0.022452816,-0.03263353,0.036640886,0.06723307,-0.031071087,0.060404044,-0.0633659,-0.06608969,-0.016493985,0.105368175,-0.023621203,0.043639418,-0.008981291,0.03824715,-0.025493497,-0.03973297,-0.008156246,-0.04439906,-0.012421419,-0.05982295,0.07847454,0.08382782,-0.018399006,-0.085323885,-0.05196466,0.024119403,-3.1267948e-33,0.055986185,-0.09109237,0.009141789,-0.09448861,0.06188281,0.02799436,-0.00014571357,-0.0056174407,0.06638292,0.02345551,0.0843252,0.023518452,0.008156499,-0.022329316,0.004274538,-0.037457388,-0.07030022,-0.0020403434,-0.045763034,0.019902494,-0.062448055,0.034360357,0.031030245,0.03939557,0.03153063,-0.005853705,-0.08073491,-0.021280635,0.08407774,-0.0017326076,-0.010102286,0.1035936,-0.048586607,-0.03558268,-0.082998514,-0.019314377,-0.07227966,0.017796071,0.06659932,-0.055922043,0.0062360554,0.029808348,-0.011734486,0.018500892,-0.00932541,0.094663985,-0.12600246,-0.034817904,-0.0277784,-0.024856484,-0.010941985,0.0076851123,-0.006337377,0.01536874,0.07591174,-0.012303284,-0.019381069,0.0008398873,-0.019286478,-0.007057167,-0.019422248,0.018451983,0.017962193,0.013029752,-0.008665895,0.056516543,-0.014176023,0.07843847,0.021777304,-0.0100456895,0.073091656,-0.04386919,-0.032189857,-0.038213793,0.015055304,-0.022730125,-0.003092783,0.027611686,0.05562776,-0.018846864,-0.11862513,0.045738965,-0.052456267,-0.08065595,0.0044598584,-0.008178875,-0.0329259,0.09242243,-0.020979743,0.04422553,-0.0054001356,0.028022734,-0.091502234,0.015052433,0.056614075,-3.7069785e-08,-0.047827173,-0.04654696,0.08935238,0.038975988,0.032195464,-0.024858624,-0.022244303,0.0887106,0.083310604,-0.022750307,0.052395865,0.088164076,0.031334423,-0.07767277,0.05610399,0.08480752,0.044391405,-0.053672343,0.007797006,-0.010334078,-0.07168927,-0.014817038,-0.0318153,0.026411436,0.011303687,-0.07128737,0.006993661,0.040656622,-0.021738932,-0.05288703,0.038190313,-0.0046596355,0.0014967718,-0.088476285,-0.07687218,0.014245695,0.06970657,-0.018184524,0.03287201,-0.0075502936,-0.0065011224,-0.11960437,-0.013406606,-0.0196923,-0.020502701,0.075040035,0.010180212,0.012494751,-0.03606567,-0.11112748,0.024890801,-0.08131154,0.010547664,-0.051443756,-0.06922946,0.09443643,0.0010833563,-0.026920471,0.037534967,-0.050568208,0.08186048,-0.016781513,0.16152692,-0.001065987 +1.12.1.4,The enzyme from Thermotoga maritima contains a [FeFe] cluster (H-cluster) and iron-sulfur clusters. It works in the direction evolving hydrogen as a means of eliminating excess reducing equivalents. ,384,1.0,0.0065517253,0.031369,-0.11990155,0.09659182,0.12205875,0.074239664,-0.06091108,-0.019920653,-0.019072875,-0.12493424,0.012115707,-0.031126494,-0.032560155,-0.05878949,-0.033369694,-0.016069146,-0.065603994,0.013902119,0.028121138,-0.06478481,0.0046644076,-0.028492121,0.042875882,0.023865914,-0.08037323,0.0968794,0.016008275,0.011653291,-0.049662642,-0.079502195,-0.0033509908,0.037733875,0.08984096,-0.02792705,-0.0026413733,0.113861576,-0.021533731,-0.023694906,-0.0031704397,-0.01877358,-0.013411949,-0.014368497,-0.024671573,0.0087580485,-0.023433264,-0.068729624,-0.023112375,-0.025359267,-0.004657184,-0.03245295,-0.051372256,-0.039358497,-0.03953891,0.10321888,0.030955702,-0.003756214,0.046824828,-0.02790798,0.0023601835,-0.046936724,0.07493675,-0.028985046,-0.008120679,-0.007839365,0.037340306,-0.03797446,0.06600175,-0.051591,0.03120577,-0.07061682,-0.019321023,0.047185376,-0.029693622,-0.007946008,-0.023568677,0.11094065,0.051223453,-0.032128878,0.10446095,0.055568513,-0.053002946,-0.006759481,0.058644027,0.059985455,0.012797838,-0.00090776413,-0.021785967,-0.092337474,0.013247027,0.009395893,-0.010641665,0.034145903,-0.0763899,0.0015724484,-0.03182988,0.007147372,0.020187791,0.03517597,0.10014038,-0.016181145,-0.022186367,0.02622715,-0.054392703,-0.12251169,-0.058044203,0.03152816,-0.02909547,0.10438105,0.1012171,0.019817054,0.019752279,-0.010347458,0.0033993612,0.0137940785,-0.052511174,0.04887401,0.12782782,-0.0153356,-0.03209624,0.04274379,0.036971394,0.02589525,0.03944663,0.07302471,-0.0027185648,-0.016742645,-0.23104495,-1.6131223e-33,0.042657755,0.0032331005,0.05508275,-0.03960488,-0.019005604,-0.056634713,-0.108447194,-0.021276383,-0.0030183725,-0.022604294,-0.07255757,0.024062082,0.03304743,-0.065819845,-0.032222036,-0.10839229,0.0124231335,0.010605657,-0.028530875,-0.038922843,-0.01903693,0.06293031,-0.021372309,-0.052449163,-0.023610212,0.10914422,-0.010436639,-0.04115398,0.028142301,0.007432545,0.015287625,-0.063831225,-0.13489866,0.054593757,0.06619657,0.03530708,0.017730454,-0.041145604,-0.058270507,-0.0363935,-0.019079188,0.029425066,0.047480155,-0.078975014,0.11179355,-0.054294888,-0.031561658,0.025275972,0.034339555,0.047611658,-0.04809795,-0.047195483,0.08291451,0.004357234,-0.086292304,0.023757214,0.0062105716,0.048146933,0.030312577,0.08887872,-0.0152381435,0.01458524,0.00897005,0.06552397,0.039620962,-0.0025648875,-0.0060837804,0.073090345,0.036058024,0.15144946,-0.056807324,0.08359945,0.05587568,0.036807515,-0.015448284,-0.05200676,-0.039912675,-0.045957845,-0.02267911,0.026818719,-0.03435625,-0.075617895,0.021821806,-0.04195237,-0.048538286,0.00864652,-0.045599338,0.008627628,-0.014583138,-0.00073714263,-0.00077941694,0.015055582,0.043389786,0.00897341,-0.024471126,-2.8382805e-34,0.0277146,-0.05041186,0.03430327,-0.07160046,-0.040250704,0.07702387,-0.0013659245,-0.023018457,-0.058691807,0.027231585,0.07224962,-0.04958098,0.017578179,-0.14548519,-0.010353974,0.05721291,0.058684316,0.04308987,0.052052155,0.0406273,-0.052894168,0.067555524,0.0011587387,0.008279214,0.029173298,-0.024836713,0.010138012,-0.0021691264,0.038004678,0.058377933,0.013387472,-0.044699587,-0.02132477,-0.07766459,-0.007999254,-0.028047632,-0.03858607,0.012779761,0.09871164,-0.0028334365,0.012870703,-0.051298585,-0.0008993444,0.100736156,0.030484298,0.055961523,-0.050863184,0.03001635,0.006661029,0.062633894,0.015017899,-0.09071427,-0.06722599,0.008209918,-0.02578577,9.894384e-05,0.020308407,0.055655215,-0.08302239,0.06476523,0.023557816,-0.07867212,0.032056615,0.027730487,-0.015823107,0.04136143,0.0036423549,-0.0013300198,0.038556505,0.07852109,0.042374924,0.08318905,0.033773012,0.05363263,0.018220222,-0.042953826,0.023741966,-0.020115491,-0.02476624,-0.0077329953,0.028145086,0.039671015,-0.022256155,-0.08399193,0.097112715,-0.07203873,-0.03071987,0.06775329,-0.040469903,0.03955929,-0.03935283,-0.0046637733,-0.009222034,0.0013035679,-0.06956723,-2.6993817e-08,0.029574528,-0.09609916,0.027686957,-0.03030272,0.013557055,0.022808831,-0.011010691,0.010780724,-0.018498864,0.0017033082,0.010310923,0.09333446,0.018604543,-0.032756906,0.028950483,-0.05497479,0.025119895,0.06420832,-0.023249239,0.025214987,-0.0580685,-0.04052016,-0.077497736,0.03696594,0.05099946,-0.06611111,0.031115538,-0.019003203,0.01014167,-0.1096547,-0.034708958,0.015587902,-0.017886061,0.027920239,-0.063486956,0.052969653,-0.032134287,-0.025978697,-0.060604636,0.03648861,0.06106676,0.010226082,-0.026644133,-0.014217658,-0.043723986,0.006294941,-0.017933812,0.022966467,0.023567805,0.041056268,0.052318353,0.011679826,0.008275526,-0.041442066,-0.08642308,0.06191853,0.03663553,-0.037085507,0.062044833,-0.041506935,0.06458911,-0.058388162,0.08827401,-0.031012163 +1.13.11.57,"Contains non-heme Fe2+. The enzyme is a ring-cleavage dioxygenase that acts specifically on 3,4,5-trihydroxybenzoate to produce the keto-tautomer of 4-oxalomesaconate [1,2].",384,1.0,-0.0063096695,0.021877808,-0.10237854,0.020385176,0.04404297,-0.048428316,-0.024605416,-0.010226113,-0.0022163163,-0.062269565,-0.053691063,-0.08186347,-0.09243776,-0.027408844,-0.0573856,0.042311966,-0.00080286973,0.0048123663,0.0037267227,-0.0399048,0.0053332443,0.019625233,0.06397591,0.006399591,-0.021551512,0.06165399,0.09363175,0.0014230532,-0.08043954,-0.12588425,-0.013464269,-0.02148274,0.015054921,-0.0420448,0.0059249178,0.09325511,-0.023789419,-0.0716404,0.035483222,0.014908851,-0.007899484,-0.07176361,-0.06449284,-0.004674712,-0.025180068,-0.058200423,0.024330106,-0.0067734146,0.021074636,0.00813059,-0.0674012,-0.06003156,-0.018866302,0.07710649,0.029262763,-0.0051270784,0.0067059803,0.06456281,-0.04790139,0.03395161,0.0014621264,-0.042897496,-0.0339871,0.060400423,-0.04028986,0.0024750035,0.056605853,-0.08609117,-0.030091122,-0.079025775,-0.040385034,-0.044806477,0.011762887,-0.017580396,-0.056078847,0.044402264,0.06887468,-0.009451666,0.08081094,-0.0024666253,0.018767549,0.017205466,0.06563229,0.09199345,0.0008195035,0.061270438,-0.03676058,-0.053540852,-0.0033051025,0.06015007,0.01253398,0.05931127,-0.040486142,0.0067360937,-0.023224201,0.054284126,0.061257854,0.055863142,0.013534461,0.004448447,0.017789846,0.03895587,-0.021441083,-0.055227347,-0.056092743,0.013023824,0.0042953216,0.035303507,0.00702846,-0.013232727,-0.018519748,-0.012588702,0.08442983,0.0087278625,-0.031095108,0.03005488,0.061607137,-0.04907198,0.011084864,0.017646426,0.052017264,-0.015318171,0.026218697,0.00050133886,-0.07371267,0.0029449668,-0.11680679,1.4000278e-33,0.046958487,0.07539313,0.06686943,0.0147008635,-0.03483325,0.013580655,-0.08909374,-0.038727157,-0.027731055,-0.02721324,-0.12855546,-0.07744792,0.06955073,-0.06110709,-0.005854128,-0.047782633,-0.06846463,-0.0003427927,0.056068245,0.04416723,-0.016886702,0.050402824,-0.0742055,0.0048748082,-0.046034895,0.08330906,0.0118840765,-0.031184942,-0.012751002,0.020777695,-0.03703275,-0.057773676,-0.045882765,-0.014864966,0.045551647,-0.008406694,-0.024924356,0.006117257,-0.066667214,0.072332114,-0.0020415327,0.020559119,0.0060250913,-0.05599935,0.03733667,-0.1174422,-0.026142573,0.12775633,0.049526118,0.12922703,0.015291266,-0.03824611,0.1274469,-0.010033258,-0.07304476,0.06271515,-0.06043705,0.028598664,0.12316423,0.031244876,-0.019237287,0.04167226,-0.010399637,0.009247435,-0.0054902206,-0.04289109,-0.076227896,-0.02491383,-0.0010384982,0.06173486,-0.016073337,0.05148517,0.115045264,0.03316889,0.08782725,-0.079219356,-0.038999803,0.0087909335,0.103416,0.021820987,0.07897699,-0.040867105,0.069982946,-0.058763694,-0.011855516,0.039223675,-0.053492453,-0.017218245,-0.020093013,0.09179163,0.03490218,-0.09726653,-0.092882544,-0.036337905,0.050755125,-2.0442052e-33,0.15731351,-0.04535507,0.010216903,-0.06977392,-0.032534745,0.06311628,-0.00727405,-0.043733537,-0.007123827,0.033519067,0.119879045,-0.002403023,0.063582055,-0.061741006,0.043330383,0.02808443,-0.060791373,0.006217759,0.020366445,-0.01407861,0.045554142,-0.0076780473,-0.10356852,0.024983866,0.030876527,0.01040261,-0.06390699,0.036737017,0.08157906,0.039348356,-0.018643593,-0.02851383,-0.0042987084,-0.030336054,0.022227405,0.020784587,-0.012878473,0.027297245,0.047142413,0.03355096,-0.06981658,0.009840214,0.021949314,0.08319409,0.046259902,0.050966553,-0.083250746,0.014565893,-0.009807045,-0.034806646,-0.025722248,0.024756072,-0.11088065,0.029088708,0.065858506,-0.012441705,-0.02516573,0.024075884,-0.03684808,0.027790729,-0.04639989,-0.038632352,0.12884092,0.02948981,0.083983816,0.048751365,-0.043319326,0.079741046,0.0029998405,0.053230383,0.04518671,-0.021253685,-0.012947094,-0.036435176,-0.0073367613,-0.04298943,-0.011036287,0.019696888,-0.03359825,0.01661791,0.06725774,-0.024276229,0.009983567,-0.08854567,-0.020218417,-0.08933695,0.05289542,0.07304064,-0.06850802,-0.0015675883,0.009345039,0.009359641,-0.07002848,0.0610337,0.042461127,-3.7039417e-08,-0.012610669,-0.09446428,0.000121271994,-0.032995343,0.036086794,0.070980825,0.03889832,-0.008173857,0.037980773,-0.03806032,0.033510193,0.056479096,0.017798623,0.016899945,0.045702983,-0.0023422102,-0.014754011,0.07278754,-0.012682217,-0.00020635786,-0.018966623,-0.025215039,-0.08873368,-0.013477368,0.06453218,-0.047791917,-0.018052958,-0.020270644,0.063111216,-0.046190657,-0.051808547,0.054883897,0.0027957426,-0.08882716,-0.122682676,0.028751602,-0.041734915,0.022246057,-0.06437337,0.009567009,-0.013280182,-0.020593852,-0.036606133,-0.019523881,0.0056913514,0.03291427,0.011123471,0.017707925,-0.038644392,-0.0561479,0.003881065,0.004965575,0.039790485,-0.03389235,-0.09150519,0.059362635,0.043991163,-0.0073908498,0.023550764,-0.09396962,-0.0113800345,0.010340902,0.1634559,-0.0057530706 +1.13.11.58,"Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids.",384,1.0,-0.07094151,-0.07404962,-0.106222875,0.040537857,0.13262005,0.12804365,-0.09519223,-0.028542213,0.00971475,-0.067906044,0.039019737,-0.018183015,-0.08327494,-0.085108384,0.025856094,-0.016104985,-0.03261866,0.01903116,-0.038716678,-0.036425687,0.081889115,-0.011893815,0.050621547,-0.019030767,0.033061795,-0.0019618727,0.030374536,-0.08077956,-0.031365372,-0.10157492,-0.012149326,0.009309161,0.07134992,0.0067197406,-0.027637258,0.045250114,0.026283387,-0.092351824,0.015203074,0.011466828,0.02221929,-0.03690005,-0.008001601,-0.04940944,-0.04533877,-0.038478073,-0.020123318,-0.036849003,-0.0145068485,0.006918906,-0.019770483,-0.080464035,-0.018575583,-0.034468494,0.017937928,0.017676057,0.0406525,0.0051760906,-0.024694169,0.05006729,0.079774946,-0.024284279,0.024833564,0.0906142,-0.058889527,-0.056789692,0.0456,-0.034081593,0.03345576,-0.12302916,-0.046480548,-0.02703065,-0.04651643,0.015711717,-0.09176422,0.089489885,-0.04042816,-0.017328396,0.056939565,-0.01988679,0.0048304084,-0.016159417,-0.06436748,0.09127208,0.016282482,-0.009035967,-0.0038635132,0.0078879995,-0.0033739773,0.07340406,0.04690082,0.05934489,0.032724727,0.08020412,-0.040341027,0.06271772,0.11890247,-0.061324682,-0.05329707,-0.034380946,-0.017078815,0.095475025,-0.0022400813,-0.026863229,-0.021647425,0.007838648,-0.109617576,-0.044726253,-0.0392483,0.04670021,-0.019072168,-0.026759073,0.0424871,0.0777086,0.001407788,-0.0046353056,0.077074245,-0.09369065,-0.06586938,0.028564548,0.00453594,-0.088272035,-0.002991292,0.030067146,-0.0716268,-0.0052030124,-0.068703994,3.764175e-33,0.09729649,-0.02825836,-0.05879084,-0.012851636,-0.03566943,-0.018934242,-0.09077754,0.046765324,-0.04712961,0.023732902,-0.051340196,-0.009639934,0.044315487,0.007630973,-0.047518365,-0.01951533,0.0116091315,0.043634407,0.11144143,-0.0026759233,-0.043664046,0.05908781,-0.029243352,-0.025483483,1.2134652e-05,0.021998266,0.001329497,-0.072664246,-0.0025954482,-0.023469139,0.029800722,-0.09978519,-0.041716013,0.046190195,0.061472513,-0.02720664,-0.0008765465,-0.048555624,-0.02994515,0.025831444,0.023718804,0.04548047,0.05061415,-0.07168991,0.06714192,-0.016223218,-0.057740543,0.10910657,0.08965788,0.047850322,0.022842994,0.04684578,0.10019404,0.043240283,0.036818434,0.019189656,-0.02033852,0.02438646,-0.023853159,0.025146268,-0.008894485,0.03389275,-0.021349957,-0.0033338696,0.027921915,-0.030340988,-0.14107636,-0.013061649,-0.03786806,0.10337058,0.083342396,-0.0009676665,0.03869028,0.045920186,0.01395192,-0.012508897,-0.060055092,0.06858673,0.013780742,0.016750868,0.1056439,0.026499463,0.0029261785,-0.016975394,-0.09765496,0.039571248,-0.06941448,0.04068722,0.009588406,0.014158118,0.062235244,-0.031648334,-0.025689146,-0.014058694,-0.001028079,-3.542019e-33,0.073642574,-0.042475097,-0.00033572,-0.07401961,0.004196525,0.06337972,-0.0069674747,-0.06032508,0.031646017,0.0077033187,0.043902613,0.0030021246,0.08870922,-0.08979335,0.028110059,0.022505598,0.0077591646,0.06427963,-0.041814122,-0.0075455583,0.020273281,-0.022040356,-0.046228785,0.023007916,0.066413775,0.009458835,-0.05837307,0.06245454,-0.07281098,0.057504445,0.09326952,-0.026743533,-0.059690822,-0.066988,-0.0073888446,-0.0034637398,-0.051013328,0.061233398,0.001986776,0.008174444,-0.07776488,0.023688732,0.065972224,-0.028134683,0.06699424,-0.016739104,-0.09072521,-0.05474131,0.03867309,0.01699488,-0.038717296,-0.0002218689,-0.0036741116,0.08216343,0.052563347,0.051556215,-0.012554258,0.05442142,-0.018975224,-0.08862741,0.04360853,-0.043370437,0.022399528,-0.018635903,-0.060616437,0.057298448,-0.055331018,-0.010831525,-0.061659582,0.036502074,0.023576057,0.008486731,0.01986106,0.029530527,-0.04315283,-0.040251747,0.057437267,-0.03837507,-0.059732225,0.0068617044,0.037244998,0.058666043,-0.0047522266,-0.08768708,-0.040820647,-0.012833471,0.040226214,0.024119433,0.05707853,0.041636806,-0.04946155,-0.0211153,-0.07589681,-0.024276549,0.08665609,-4.0243044e-08,-0.071289144,-0.051317114,0.066329494,-0.028810922,-0.04076478,-0.016510757,0.038069937,-0.041072626,0.030298753,-0.113378026,0.018867496,0.109269604,0.05571779,0.037646,0.10312426,-0.038862217,0.04750805,0.025280029,-0.022990132,-0.020309383,-0.025470655,-0.006086746,-0.02876087,0.0030840163,0.02166444,-0.037925735,0.0033512027,-0.008477524,0.08954073,0.05515753,-0.0063618305,0.040760014,0.09733792,-0.108305916,-0.04360396,0.04147459,0.06580409,-0.022572022,-0.05102428,0.08223799,-0.007690955,-0.026667267,-0.07375455,0.0031927552,0.045768455,-0.0053291237,-0.0007670221,0.03972702,0.005917239,0.068948895,0.02984664,-0.02280185,-0.021710962,-0.015834758,-0.025109293,-0.015002767,-0.0031822615,-0.009398747,0.00843629,0.030133478,-0.04333871,-0.034315236,0.17656918,0.003006251 +1.14.11.33,"Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N1-methyladenine, N3-methylcytosine, N1-methylguanine, and N3-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.",384,1.0,-0.02201934,-0.010963962,-0.04690044,0.0576491,0.010371997,0.021691104,-0.013643742,0.029615588,-0.060079627,-0.041439343,-0.0128037045,0.12321462,-0.026258353,-0.020327283,-0.040349644,0.082046606,-0.03180781,0.04404517,0.016658965,-0.039644465,0.013218535,0.06395151,0.07877017,-0.06702875,0.0035554795,0.026336946,0.035007656,0.016162317,0.010622826,-0.09754097,0.021544304,-0.04024514,0.040793233,-0.0077657457,0.029641483,-0.0134128,0.021502761,-0.02243962,-0.0024645496,0.025920333,0.042602584,-0.005603576,-0.019824594,0.045963213,-0.055850957,-0.07180076,0.032795735,-0.041569985,-0.016762003,0.060262762,0.025800342,-0.017638868,0.032409273,0.04823985,-0.02391594,0.08680723,-0.032513283,-0.053302333,-0.03233244,0.08395046,0.05587589,-0.024534069,-0.037426326,-0.07369216,0.08606453,-0.03394751,0.123509265,-0.02718164,-0.033991314,-0.039117698,0.045288395,-0.044698346,-0.045754205,0.0025448012,-0.064150386,0.025661342,0.049612008,-0.11514994,0.05582695,0.00037195557,-0.06330291,-0.019426124,0.04363166,0.08522678,0.02804969,0.07585229,-0.019917797,0.040301207,-0.015998185,0.13970661,-0.030259542,-0.007481253,-0.022649646,-0.034600295,-0.10688493,0.018122822,0.08183626,0.05947455,0.041933414,-0.0030381996,-0.015038701,0.052341375,-0.077410966,-0.059663832,0.00047103333,0.034116052,-0.016941402,0.014242146,0.019128518,0.004728882,-0.04215933,0.025740217,-0.04431626,0.0426518,-0.043035086,0.015602859,0.052837126,-0.0073855557,-0.07405939,-0.054801103,0.07252645,-0.01654235,0.0216244,0.016491173,-0.049200706,-0.01863771,-0.020112563,1.9851491e-33,0.014593418,0.05481497,-0.010429163,0.035945926,0.00797075,0.085405305,-0.063968234,0.06605245,-0.053518247,-0.018122785,-0.031487864,-0.0508437,0.10010786,0.016673122,-0.04614484,-0.07503789,-0.02682178,-0.01372802,-0.0072678975,-0.068296924,0.043416493,0.04019875,-0.02647861,0.006196578,-0.059037093,-0.033009607,-0.017303769,0.050057832,0.08119612,-0.038478326,-0.017803567,-0.05655675,-0.058261827,-0.014394713,0.05969943,0.08879019,0.013853674,0.0020528196,-0.00846742,0.09883177,-0.009179756,0.015047058,-0.018703332,-0.052529197,-0.0155216,-0.042645693,-0.0663323,0.006062278,-0.038478073,0.02075294,0.056951687,-0.00091337634,0.07416025,-0.013411699,-0.025440305,0.011146634,-0.071411766,-0.056520857,0.02028653,0.05483916,0.026984373,-0.09189506,0.017485945,-0.011128916,0.049275346,-0.031187981,-0.029398603,-0.024239847,0.016225364,0.010533594,-0.012625523,0.0059380773,0.105839215,-0.0138208205,-0.062742546,0.035814416,-0.094314866,0.06602407,0.005431758,0.05623019,-0.024425235,-0.042951483,-0.0013738364,-0.03793065,0.012137166,0.052939344,-0.007950665,-0.06149697,0.024368994,-0.004695748,0.06275964,-0.07097853,-0.025797646,-0.119447656,0.043498985,-2.592853e-33,0.053056985,-0.07755057,0.03559678,-0.01442736,-0.04768387,-0.029746735,0.08505992,-0.0013321259,-0.08789855,-0.07249209,0.023805803,-0.0041219518,-0.008499249,-0.09668246,0.0017294667,-0.015289774,-0.0032193724,0.09211327,0.021553628,0.0016463825,-0.020678908,0.13627364,-0.08515526,0.092693694,0.053254627,0.0023125806,-0.081186496,-0.017689697,0.09745879,0.09273654,0.03135963,0.026084024,0.0010906621,-0.023390418,0.06327439,0.09046789,0.017371992,0.005156974,-0.00795947,-0.020688087,-0.016019514,0.03821178,-0.039802574,0.1580615,0.062327906,0.06841246,-0.14770123,0.07868498,0.02040765,0.013377709,0.07879226,-0.014871204,-0.0696493,0.007971602,0.11722087,-0.026771015,0.023589477,-0.08937914,-0.0028524536,0.041904848,-0.05407927,-0.006317916,-0.009848388,-0.038907673,0.02334837,0.028613506,-0.013521924,0.056868065,0.015375817,-0.07136276,0.0281031,0.06485573,0.04992884,-0.029800395,-0.01750614,-0.0456549,-0.034295216,0.012407951,-0.09550056,-0.00508097,-0.012256118,-0.06337616,-0.038003214,-0.024073735,0.002926515,0.0164411,0.040108208,0.08350539,-0.059408344,-0.0842396,-0.07214856,-0.07695177,-0.034326587,0.030738546,-0.006075698,-3.629835e-08,-0.00828526,-0.054552484,0.030993735,-0.092356585,-0.01748542,0.04255897,0.011102726,0.03784372,0.09767397,-0.04432731,-0.027728012,0.09494512,-0.0049182237,0.015044657,0.009571213,-0.01158234,-0.020416608,0.063093774,-0.030156758,0.011181387,-0.08171835,0.062092412,-0.108255364,0.016645804,-0.030050073,0.01465108,0.052437693,0.028234731,0.06367249,-0.11478395,0.045022804,0.0029048156,0.07022874,-0.0070245964,-0.030342653,-0.048843987,0.119125865,-0.020513352,0.021002833,0.04027015,0.011797616,-0.0033922326,-0.047341935,0.019904653,-0.06139792,-0.04532947,-0.016200352,0.054143045,-0.057779748,-0.02555977,0.03720986,0.0043466943,-0.033718564,-0.050502803,-0.061856255,0.01980283,0.022628557,-0.0022829839,-0.019807324,-0.014901323,0.012003511,-0.032264456,0.16908482,-0.07065104 +1.14.13.123,"A heme-thiolate protein (P-450). This is probably part of the biosynthesis of many sesquiterpenoid lactones. In Lactuca sativa EC 1.14.13.123 is a mutifunctional enzyme with EC 1.1.1.314, germacrene A alcohol dehydrogenase [2].",384,1.0,0.009919399,-0.023567326,-0.040168036,-0.007377339,0.064019054,0.06480031,-0.009749418,0.14629284,0.03483441,-0.044609193,0.005365263,-0.031078026,-0.11092638,0.0012638837,-0.03012183,-0.030087234,-0.07495322,0.009183746,-0.001305778,-0.07279399,0.042310886,0.07424041,0.011398535,0.062347196,0.051026102,0.012912311,0.055822458,0.049925927,0.003331131,-0.06997643,-0.02881824,-0.07489937,0.030240104,-0.015542318,0.014735313,0.06781532,-0.027395448,-0.09669814,0.06036096,-0.039110273,0.14993672,-0.078299165,-0.03916848,0.031062458,-0.034665413,0.0035300185,-0.016566273,0.07260827,-0.03774936,0.021629011,-0.009280773,-0.06429343,-0.037824124,0.008038132,0.004222881,-0.027252527,0.06935118,-0.027231004,0.03382448,-0.006618422,0.009815394,0.06931436,0.010532015,0.013765209,-0.010048887,-0.03834724,0.078790255,-0.073756315,-0.006808488,-0.056663513,-0.048693016,-0.102756895,-0.022895548,0.037459735,-0.052222207,0.0733976,-0.016808832,-0.034175843,0.004655068,-0.006755986,0.060199484,0.004035044,-0.025163693,0.1349274,0.025647352,-0.07449415,0.015780868,-0.008546324,0.01094065,-0.04034898,-0.034533422,-0.0027362888,-0.055591766,-0.03234388,-0.07250651,0.08835539,0.020663502,0.0075549036,-0.02081688,-0.025729211,0.0031163471,0.07951623,-0.01030672,-0.08142721,-0.10933506,0.023576848,-0.015755225,-0.001206176,0.068380035,-0.06407653,-0.05489657,-0.06318603,0.036440007,-0.008794357,-0.03618305,0.11596101,0.022469094,-0.04598569,0.038548034,-0.021419317,-0.03880175,0.0029951143,0.061234035,0.06135214,-0.043237194,-0.053251367,-0.060468186,2.7450596e-33,0.08606101,0.021743964,0.04263488,0.0045744404,0.020322945,-0.026594825,-0.092304245,0.0674725,-0.09203506,-0.0059465882,-0.05572205,-0.1302991,0.03305498,0.0017681406,-0.00084365543,-0.02572451,-0.028050436,0.016496046,0.028309962,-0.011263584,-0.10944154,0.047980495,-0.04088164,0.07723534,0.05313234,0.059135973,-0.004038834,0.0060767443,0.039139833,0.019392768,-0.0106179165,-0.031400498,-0.071125895,-0.013325433,0.007216884,-0.020009542,-0.0006452561,0.01095733,-0.07513279,0.045584608,0.004767595,0.02010202,0.035640396,-0.05998988,0.014118855,-0.05416257,-0.08059859,0.0384041,0.064574495,0.03676358,0.028905991,-0.051434588,0.07929185,0.012787778,-0.06982682,0.008915281,-0.060425922,0.08475315,0.051368292,0.050661128,0.13916239,0.030663688,-0.042656187,-0.008974831,0.0148053495,0.07743289,-0.053842675,-0.05280104,0.034618694,0.03818706,-0.06756331,-0.02001616,0.04556643,-0.045142546,0.01882284,0.013426244,-0.065719165,0.044946965,0.0075282427,0.03429445,-0.027528388,-0.04691088,-0.02791891,-0.04624584,-0.0255968,-0.04184313,-0.008330439,-0.0016085358,0.0016798857,-0.0018390905,0.042184345,-0.054664556,-0.03071463,-0.019801717,-0.010396017,-3.384041e-33,0.052551564,-0.09793071,0.027950708,-0.02295463,-0.029823963,0.016879728,0.023959635,0.004583388,-0.022203887,0.028505126,0.14404936,-0.105087176,0.03512808,-0.08622922,0.0004443961,0.05929198,-0.03279217,0.04150876,0.0323406,0.07900895,0.06173568,0.07637386,0.03409325,0.044397116,0.049579825,0.060909007,-0.023471965,-0.0040045455,0.023128143,0.04129958,-0.05872051,0.049497664,-0.06406089,-0.04470471,-0.13392256,0.020965569,0.0052672904,0.035268296,0.0061736833,0.017703865,-0.01513004,0.08553629,0.04793981,0.06353072,0.0707117,0.06297528,-0.05026186,-0.023074685,0.0036422869,-0.03959168,0.035269722,0.019662231,0.0040721092,0.051430967,-0.016228896,0.03797414,-0.019139847,0.046569757,-0.00418222,-0.07441881,-0.035147995,0.0329073,0.011498628,-0.0015111527,0.041941132,0.02030211,-0.11644673,0.0066789463,0.034074195,-0.031760342,0.05605294,0.041488953,0.018676758,0.081037626,-0.027567377,-0.01497345,-0.023252524,-0.05008549,-0.0017873504,-0.014858859,-0.0005694967,2.916802e-05,-0.059216246,-0.024438715,-0.018783726,-0.06475806,-0.01324595,0.12481175,0.036383793,0.008424304,-0.05944127,0.02849295,-0.09439675,0.12432234,0.07218237,-4.171798e-08,0.007014109,-0.08029466,-0.04215012,0.020210188,0.033524957,-0.009418427,0.014277986,0.006050913,0.06865974,-0.028804155,-0.019273093,0.06819296,-0.006079846,-0.014775109,0.03428039,0.015387567,-0.030101705,0.018581172,0.0060938704,0.014636719,0.01991655,-0.028832685,-0.03008101,0.027966201,0.042028494,-0.08396027,-0.049214553,0.00090579415,0.008878519,-0.065997146,0.019823145,0.06727169,-0.023572396,-0.0409157,0.01433997,0.0942409,-0.06993022,-0.060563907,-0.03047774,0.01771667,0.0021043422,-0.092770204,-0.07211392,-0.043975815,0.016328704,0.02945508,0.030271087,0.042899832,-0.04230401,-0.02301578,-0.0031381464,-0.006826841,-0.015293497,-0.0136006875,-0.082873754,-0.013939284,0.04190366,-0.059570484,-0.030763172,-0.0978199,0.051319826,-0.013975274,0.23016702,-0.04814693 +1.14.13.124,"A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-phenylalanine, the first committed steps in the biosynthesis of benzylglucosinolate. The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is extremely labile and dehydrates spontaneously.The dehydrated product is then subject to a decarboxylation that produces the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The product, (E)-phenylacetaldoxime, undergoes a spontaneous isomerization to the (Z) form.",384,1.0,-0.074542634,-0.007324445,-0.022412235,-0.011948298,0.08758383,0.003314166,-0.047497354,0.07044018,-0.0032711814,-0.04461249,0.044188734,-0.02008929,-0.06353319,0.0382155,-0.07772098,0.04760793,-0.09057308,0.048711617,-0.038360715,-0.045249075,0.043765523,0.02800999,-0.044405352,0.027186783,0.084924445,-0.04514347,0.101499364,-0.027034435,-0.00043791087,-0.03361193,0.03759781,-0.08003397,0.025894009,-0.024381967,0.07004058,0.10102966,-0.04813692,-0.07747795,0.059422757,0.0054465216,0.016176237,-0.10524055,-0.06785017,-0.017987115,0.0031471578,0.030136103,-0.014357604,0.06478152,-0.05534722,0.010582015,-0.023201039,-0.015680423,-0.045006298,0.052247662,-0.086135715,-0.021154387,-0.04269365,0.05538446,-0.04121542,0.017571328,0.0002680721,0.06418474,-0.07454276,-0.009166749,0.04575977,-0.055302773,0.032960102,-0.059557814,0.0418215,-0.04447726,-0.002557999,-0.027708866,0.031032473,-0.039796006,-0.04792417,-0.002965809,-0.058147244,0.035039213,0.020269668,0.007160555,0.08433347,0.03461771,0.035669494,0.059761357,0.068596326,-0.019872582,-0.09520733,0.050717544,0.030933911,-0.04510738,-0.0051719057,0.02275894,-0.058629915,0.07238021,-0.041720662,0.050488032,0.08249426,0.030469716,0.021046016,0.030516408,-0.030553745,0.046882655,-0.025974292,-0.107875325,-0.03397754,0.019499717,-0.015402168,0.037949905,0.016904904,0.050417785,-0.0077303248,-0.042969335,0.05448996,-0.0061601195,-0.0031837416,0.14122245,-0.074611604,-0.009686403,-0.01826573,-0.095878914,0.0014902602,-0.010486315,0.074600995,0.04697313,-0.07592831,0.05530679,-0.060868863,3.873977e-33,0.09600492,-0.05115231,0.011330794,0.05680999,-0.007480928,0.017621936,-0.115706705,0.06225531,0.015975246,-0.038750112,-0.06762696,-0.09262424,0.01073258,-0.018756436,-0.059272934,-0.051631123,-0.03290412,0.030878635,0.05998835,0.043457147,0.013214235,0.0015899118,-0.052868772,0.030997165,-0.017707597,0.030583873,-0.0343105,-0.0018613567,0.025733283,0.013297081,-0.04694826,-0.16549663,-0.056667566,-0.027939003,-0.023864502,0.01466519,-0.11572292,-0.020247737,-0.024408855,0.03920304,-0.0180211,0.0003303294,0.004736233,-0.07163782,0.029458882,0.027983328,-0.0086317845,0.02969357,-0.045080427,-0.023380542,0.030070065,-0.0042646276,0.052495558,-0.018480828,-0.04818669,-0.023587642,0.00410066,-0.011100513,0.034485623,0.05761975,0.08311014,0.08899416,0.029477352,0.0044064373,-0.0080299005,-0.0014946541,-0.07743659,0.009347365,0.015446846,0.051628124,-0.056270607,-0.01994486,0.10079265,-0.014197052,0.030849705,-0.11463078,0.024859944,0.04263239,0.055065777,-0.03103853,0.04555407,-0.016230924,-0.043738946,-0.022682536,-0.016026128,0.0014110478,-0.020538935,-0.044587027,-0.040065426,0.063686535,-0.011494703,-0.10347081,0.02496394,0.019624358,0.06018536,-4.261021e-33,0.08542283,-0.07267908,0.0007852859,-0.0347542,0.00930365,0.015985755,0.03547668,0.0063367244,0.03321182,0.00050200446,0.063349344,-0.01366823,-0.024601867,0.025191724,0.03223819,0.05971797,0.012608624,0.07342884,0.039035656,0.014861055,-0.0005133342,0.07984228,-0.028497752,0.005482055,0.06649526,0.027770508,-0.01212934,0.036275383,0.09102232,0.11510305,-0.055568777,0.038199276,-0.07512042,-0.0070137735,-0.04710047,0.09251384,-0.043130096,0.0006442349,0.029895004,0.037213523,-0.023155406,-0.01721596,-0.008295619,0.05892984,0.06641761,0.050246596,-0.07811519,-0.08373819,-0.010539204,-0.07855421,0.04208286,0.08224033,-0.07065462,0.017353578,-0.020837244,0.104149885,0.0030476341,0.047457434,-0.0067810644,-0.06502669,-0.07446928,-0.10247897,0.00060682744,-0.017584607,-0.016713187,0.037378095,-0.044057973,0.08777385,0.10926608,-0.035098862,0.047907665,0.027087513,0.0037731132,0.06802802,-0.03679383,-0.06577701,-0.00015423064,-0.056606732,-0.0038883393,-0.07751124,-0.037047084,-0.05148268,0.018518835,-0.074574664,-0.0048632794,-0.08143048,0.016589014,0.06763644,-0.016167197,0.024189238,0.03300813,0.00044657112,-0.05026584,0.109031454,0.08658717,-4.564638e-08,-0.009284779,-0.12679876,0.0075754384,-0.0038954392,0.020384107,0.014436804,0.044377282,0.023951339,-0.0010373462,-0.10327858,-0.01707067,0.072408624,-0.073880434,0.060210615,0.022567252,0.029905222,-0.06762971,0.033413377,-0.037642717,0.01957629,-0.02069744,0.015791303,-0.0350621,0.024415642,-0.039300982,-0.043322124,0.059830625,0.024731904,0.014098745,-0.039819963,0.027122645,0.06983076,0.0034001148,-0.0017965257,0.004858686,0.02026333,-0.026387243,-0.026449129,-0.059577677,-0.03197384,-0.043334916,-0.029357318,-0.05774056,0.040647507,0.09050453,-0.0034150737,0.05451437,0.014175896,-0.0011105301,0.043368895,0.06443667,-0.004270345,0.008786033,-0.07105239,-0.029669896,0.02228015,-0.04546708,-0.0026695642,-0.020745613,-0.06700773,0.0054532345,0.0652322,0.2177827,-0.0665362 +1.14.13.125,"A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-tryptophan, the first steps in the biosynthesis of both auxin and the indole alkaloid phytoalexin camalexin. The product of the two hydroxylations, N,N-dihydroxy-L-tryptophan, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme.",384,1.0,-0.024554303,-0.014612188,-0.027478823,0.0009925329,0.09252517,0.041607063,-0.0023126795,0.09877217,0.039650176,-0.04003389,0.020706763,-0.03993402,-0.073303245,0.061280463,-0.06763251,0.050303426,-0.046069268,0.0048353365,-0.0047970205,-0.056345843,0.041438267,0.09828759,-0.03443659,-0.001088798,0.018182587,-0.035399232,0.07168036,0.023918664,-0.007749885,-0.02194319,-0.016883895,-0.048466858,-0.015850019,-0.0031942232,0.015342881,0.11039946,-0.03555966,-0.057661496,0.0756277,0.0005391546,0.0056164353,-0.04833389,-0.092845924,0.013559007,-0.017631607,0.010935959,0.023563776,0.06156499,-0.023171319,-0.07447977,-0.034384158,-0.0394267,-0.05039056,0.042877324,-0.013623903,-0.046501935,-0.00734191,0.048942685,-0.020454131,0.037957978,-0.0033790562,0.0746456,-0.023718556,-0.013049459,0.094570756,-0.05875616,0.00039167528,-0.02569773,0.017145632,-0.028424468,-0.01638044,-0.04001138,-0.03684324,0.0359783,-0.028383128,0.033152897,-0.06996101,0.008441512,-0.025996894,-0.046776645,0.053876795,0.04268716,0.026090724,0.14309101,0.013618386,-0.038288787,-0.05246334,0.1076279,0.028077127,-0.062355258,0.0312266,0.019573512,-0.05194085,0.04814483,-0.033126075,0.07216626,0.048229896,-0.025401123,0.012377738,-0.006276511,-0.006134138,-0.018525928,-0.09744047,-0.08120389,0.012332785,-0.009118087,-0.0010765804,0.013076738,0.08661342,-0.021819944,-0.0446486,-0.06342367,0.06427371,0.024725912,-0.035856746,0.10405047,-0.07493645,-0.009166774,-0.032499775,-0.086621426,0.03621831,0.023821251,0.030295283,0.050932795,-0.06217338,0.027315836,-0.073107824,4.0575538e-33,0.09099583,-0.02825354,0.022840926,0.06199291,0.00088306365,-0.029195175,-0.0895589,0.017254354,0.004008261,0.013686981,-0.069747575,-0.11239431,0.008814214,-0.029842978,0.0031364446,-0.031960513,-0.14547588,0.013625938,0.029078167,0.054955374,-0.05474675,-0.028744968,-0.05994971,0.031632606,-0.03960798,0.05886808,0.03953892,-0.0177367,0.06852729,-0.007765206,-0.049872644,-0.0803898,-0.07415307,-0.03524284,-0.030110314,-0.025777312,-0.02646061,-0.0021501244,-0.08997476,0.023005482,0.010037801,0.08967246,-0.018581554,-0.052604135,0.08704757,-0.015812103,-0.06916511,0.08076051,0.0071029663,0.011479207,0.03485687,-0.019068887,0.05380912,-0.028301146,-0.056375246,-0.039218463,0.008060445,0.031818815,0.066119365,0.08301753,0.039243784,0.009842169,0.0020023377,-0.00011681498,-0.0363348,0.0579102,-0.047211554,-0.06137145,0.0213097,0.06118952,-0.06381645,0.023167798,0.083986625,-0.046728477,-0.020906344,-0.08339363,0.031087002,0.04185982,0.033663657,-0.015642855,0.060222037,-0.008079722,-0.002194891,-0.01002225,-0.019073699,-0.012297783,-0.01923638,-0.036788896,-0.06001987,0.06471821,0.025385194,-0.02071196,-0.02229296,0.0048329043,0.010517819,-3.4830136e-33,0.0681236,-0.08896728,-0.0052129724,-0.06187265,-0.011015545,0.040925004,-0.00085728907,0.02301624,0.06637297,0.0013549422,0.08224812,-0.041683774,0.03906814,0.02494747,0.029059632,0.011374262,-0.034644894,0.09849739,0.015452793,0.028941233,-0.004221793,0.06457588,-0.015849803,-0.015318206,0.069143295,0.055061955,-0.03757239,0.091463394,0.049071256,0.034023445,0.07073206,-0.021196472,-0.116476685,-0.006163782,-0.040665764,0.09579531,-0.0067842025,0.033266988,0.024042169,0.07657854,-0.0015224848,0.022677053,0.048287924,0.032356948,0.016847603,0.07661425,-0.077477105,-0.042630695,0.023925677,-0.079602644,0.070512675,0.0068367627,-0.081503086,0.021301514,-0.017255165,0.06095895,0.0022810353,0.040432636,0.004839629,-0.07024902,-0.05869527,-0.02698448,0.047468413,-0.0049743545,-0.04850834,0.038714927,-0.060996544,0.055443447,0.09747009,-0.0058400086,0.11077066,0.018101173,0.0033359907,0.03483656,-0.03810883,-0.036246054,-0.0028718594,-0.04652727,0.021094425,-0.0010654358,-0.012041434,0.04634497,0.0046312674,-0.050102655,0.0017614478,-0.07353553,-0.0054888213,0.13801257,0.03624916,0.024441054,0.0016265727,-0.043102648,-0.00025948015,0.09096629,0.0976418,-4.16367e-08,-0.025449056,-0.1285205,-0.0049445075,0.025410289,0.00181324,0.031354953,0.0712627,0.055168968,0.04933296,-0.10545666,0.020709107,0.022820333,-0.07327646,0.017346058,0.016567579,0.014778622,-0.017561609,0.073557146,-0.015599078,-0.015127456,-0.03099016,-0.0073687886,-0.027256764,0.007307032,-0.03860283,-0.040449567,0.02101936,-0.0312689,0.043463312,-0.07111845,-0.010087139,0.08164253,0.00038330554,-0.033107124,-0.031344935,0.052595142,-0.081855215,0.03459211,-0.021228483,-0.046194807,-0.013765437,-0.10131157,-0.098342985,-0.00745315,0.04707449,-0.03729816,0.027833456,-0.006205775,0.020138409,0.00089416147,0.08338204,-0.014920819,0.041094594,-0.05403543,-0.09448723,0.017195914,-0.034966867,-0.035610832,-0.057360813,-0.13329883,0.014343699,0.04036607,0.2364568,-0.004817687 +1.14.13.126,"A heme-thiolate enzyme (P-450). The second donor, NADPH, donates electrons through EC 1.18.1.2, ferredoxin--NADP+ reductase and a [2Fe-2S] ferredoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not.",384,1.0,-0.028473256,-0.043622553,-0.051766038,-0.03056606,0.054141752,-0.0040685,-0.028530274,0.07182623,0.015528852,0.0054562287,-0.030308211,-0.009048599,-0.043705914,0.030653851,-0.023918178,-0.034857977,-0.077168055,-0.007184496,-0.023286924,-0.018710872,0.010424377,-0.014480854,0.026250523,-0.008377329,0.033701025,0.0132812075,0.06950282,0.0014598493,-0.06318508,-0.013916916,-0.05709362,-0.05071259,0.0058228546,0.0047003953,-0.039894287,0.12191568,-0.09168383,-0.035061117,-0.08206289,-0.027448943,0.058594443,-0.10338705,-0.06512194,0.035934072,-0.028530443,-0.07692985,-0.005513878,0.030118726,0.028472243,0.095327444,-0.07120426,-0.015840232,-0.034446277,0.0590628,-0.021577632,-0.02275393,0.07049294,0.041991085,0.013236009,-0.012700046,0.019674718,-0.0350148,-0.027380455,-0.019190682,0.08680604,-0.05235763,0.040160682,-0.047164317,-0.060989864,-0.09880614,0.017893905,-0.030989898,0.06565841,0.0051219426,-0.03279013,0.017777452,-0.035814185,-0.0052604387,0.046043422,-0.025967695,0.048285518,-0.010248424,-0.06447989,0.13537346,0.08055565,0.073120594,-0.049447138,0.072505064,-0.01592211,0.035576932,-0.044748675,0.06079135,-0.049927346,-0.017825153,-0.1213757,0.024621872,-0.00859057,0.010063137,0.0025936672,-0.029686334,-0.019157294,0.10825449,-0.002266942,-0.08043102,-0.028575212,0.025241565,-0.05947575,0.06639824,-0.019731816,0.004672688,0.035304815,0.0012418198,0.016201729,0.05152009,-0.006621409,0.18114908,-0.015315143,-0.011615711,-0.057571173,-0.037146017,0.022077067,-0.00081917376,0.09193295,-0.017502854,-0.02721439,-0.037714038,-0.04513259,3.5462038e-33,0.05579428,0.026506132,-0.04539958,0.06693391,0.0069021676,0.06093914,-0.0871013,0.06618737,-0.021666463,-0.026260966,-0.012846989,-0.06474591,0.08448433,-0.020194847,-0.029819932,-0.06188745,-0.007652706,-0.03643728,0.052266978,0.0008781262,0.09022061,0.021666871,-0.025802637,0.083505616,-0.02915174,0.044927046,-0.07183281,0.14040829,0.041429628,0.0076374165,0.002489994,-0.131067,-0.03203271,-0.054295886,0.045394633,0.0017237857,-0.027712958,-0.012566676,-0.049613193,0.107525535,-0.01360716,-5.3179072e-05,0.03720806,-0.06365064,0.05722872,-0.07611888,-0.056439016,0.04599111,0.024996378,0.07415989,0.013764896,-0.05372946,0.11521922,-0.0416939,-0.05993365,0.009878313,-0.03970091,0.021991601,-0.015272249,0.06784171,0.092976086,0.03019206,0.019477546,0.038112774,-0.03888267,0.017794741,-0.060380466,-0.028141515,-0.02076623,0.08664268,-0.031252705,0.054968778,0.06609873,-0.059360042,0.03850175,-0.03821982,-0.007273139,0.0297505,0.07067259,-0.052698918,0.012075803,0.0051494613,-0.01799182,0.04713477,-0.024535395,0.048423048,-0.050108258,-0.03505101,-0.047392115,-0.027396895,0.041107114,-0.10760819,-0.013173623,-0.08514337,0.01821519,-4.1261788e-33,0.035912942,-0.019797992,0.08897537,-0.053349704,0.017674722,0.06553061,0.08484411,-0.02916573,-0.021026619,-0.026670597,0.103459746,-0.006795407,-0.009912516,-0.046901323,0.01972732,0.09409969,-0.042389456,-0.04834175,0.028426556,-0.021813959,0.007990025,0.088892944,0.06753122,0.042484574,0.048606202,-0.024871308,-0.018277733,-0.039716505,0.12609981,0.06607644,-0.008863596,-0.004749163,-0.07239598,-0.0147178965,-0.013207575,0.086745694,-0.01884317,0.018077713,0.02905217,0.054966766,-0.045877557,-0.016034093,0.016840793,0.05512916,-0.0015646876,0.05653286,-0.05709308,-0.017116645,-0.02427541,0.0013064214,0.027383745,0.019873876,-0.099054284,0.046132896,0.020651395,0.03708109,0.07254428,0.07155203,-0.001278923,-0.06569592,-0.05167366,-0.070453435,0.037465353,0.034767114,0.02068619,0.0021353632,-0.04510616,0.099620335,0.033195812,-0.00031747427,0.09005764,-0.01875381,0.003042711,0.01821154,-0.027509063,-0.045551036,0.026488338,0.0053840945,0.019585403,-0.0567387,-0.011032446,0.048480563,-0.053121876,-0.04564294,-0.008509673,-0.08117949,0.0024133455,0.047926888,-0.011348269,0.033416968,-0.0668521,0.034105077,-0.04728018,0.019547138,0.09081983,-4.7193495e-08,0.0065576704,-0.06512001,-0.03483921,-0.02614591,0.055650294,-0.03222621,-0.0055239405,0.020647783,0.047498204,-0.0014252469,-0.05272032,0.12592828,-0.01751644,0.020310977,-0.0044831764,-0.010409425,-0.018882088,0.060195506,-0.045859005,-0.025808237,-0.005716239,-0.0100535415,-0.10476633,-0.0033183661,-0.0055023883,-0.05771371,-0.09826576,-0.036524225,-0.005600414,-0.042042363,-0.0053151282,0.004012784,-0.030057538,-0.08536938,0.014211049,0.045430727,-0.04206124,0.02377466,-0.05042504,0.04971078,-0.03292639,-0.10605665,-0.057204146,0.047975373,0.033507146,0.020730825,-0.017594077,-0.0010535767,0.0034260715,0.020819532,0.025731344,-0.01592112,0.009895505,-0.100747734,-0.11607245,0.06544608,0.012440232,-0.04445003,0.02426905,-0.07844041,0.020766664,0.049123675,0.14511362,-0.07956473 +1.14.13.127,A flavoprotein (FAD). This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds.,384,1.0,-0.07120543,-0.06889978,-0.100346535,0.0032002002,0.11880147,0.008240267,-0.008733399,0.07566804,0.05500796,-0.030495472,-0.0061490363,0.07189347,-0.0904046,0.000598296,-0.07085969,0.019665062,-0.08162537,0.025226204,-0.054272775,-0.024928523,0.014516739,0.024373626,0.035962377,-0.016194545,0.009557382,-0.026424387,0.022833789,-0.058610693,-0.035823032,0.01483309,0.12030958,0.055711463,0.068276,-0.012814818,-0.02039742,0.054155167,0.07523441,-0.032259524,0.020695075,0.004242965,0.019133579,-0.006956523,0.01492102,-0.03128338,0.09735154,0.010416298,-0.050358318,0.08052688,0.018139327,0.017881036,-0.025344713,-0.026776435,-0.10315208,0.05392226,0.0030782924,0.056730364,-0.000462933,-0.10082792,-0.00831671,0.030551426,0.0009783919,-0.03465076,0.042389203,0.013040841,0.02775909,-0.078446895,-0.029274857,-0.03244262,0.07232021,-0.014882622,-0.027420389,-0.028448844,-0.06931269,0.0525881,0.030923866,0.06664472,-0.0733493,-0.014604667,0.06865778,-0.024487702,0.10168796,-0.03429018,0.09687477,0.064900324,0.049245525,-0.051352844,0.01702793,-0.025849368,0.0040765894,0.08014935,-0.013436221,0.016210226,0.029566225,0.017255455,-0.07862876,0.05871596,0.029110646,-0.08996971,-0.059215005,0.005624755,-0.049274907,-0.016498918,0.033593025,-0.030993242,-0.07568087,-0.06762054,-0.040283665,0.098497376,-0.04135558,-0.05414526,0.02049758,-0.038608883,0.022155337,-0.103882,0.020085448,0.031672847,-0.00920794,-0.05808168,-0.017110653,-0.0016407405,-0.056851763,0.08050095,0.02083263,0.09752596,0.014408126,0.009417734,-0.101398975,1.5785714e-33,0.053574923,0.0010991055,-0.04631167,-0.01377998,0.0045481035,-0.022096824,-0.0577216,-0.021738395,0.019499745,-0.06756503,-0.019321768,-0.034526713,-0.0036626626,-0.066781245,0.076744534,0.022151591,-0.030241294,0.001186836,0.088936076,-0.08915612,0.05501949,0.022673942,0.0045899334,0.038053323,0.050097786,0.0032320656,-0.07468178,0.033738382,-0.017772349,0.030975133,-0.013842484,-0.058229018,-0.082606204,0.010541233,-0.021422394,0.025765125,-0.07395494,-0.10147346,-0.08607919,0.08231143,-0.00400742,-0.021894336,-0.021682547,0.00870556,0.034371853,-0.030187508,-0.055706885,0.10423787,0.0039811847,0.1162035,0.02310956,-0.03929596,0.103604466,0.06844273,-0.085889235,0.035667002,-0.020587519,-0.039075118,0.013555761,-0.028081063,0.019831013,0.060327176,-0.04524502,0.10344318,-0.07267714,-0.0043250076,0.021094203,-0.05584287,0.0070884386,0.13291489,0.011106179,-0.020860353,0.060834777,0.014272443,0.05695595,-0.039443,-0.049702615,-0.045354035,-0.013343387,0.039518364,-0.031956002,-0.013350303,-0.039743785,-0.0057342323,-0.033643585,0.035445407,-0.03143817,-0.047142062,0.029296966,-0.019833328,0.056271713,-0.08430633,0.010963711,0.05478366,0.018088581,-1.1988919e-33,0.0452378,-0.09621345,0.03074467,0.02799474,-0.020617409,0.018040968,0.00057091546,-0.037623875,0.007216752,-0.06003382,-0.017477471,-0.08196713,-0.015995756,0.012005206,0.03639679,0.01653919,-0.020582095,0.0014388098,0.030213548,0.045428943,-0.03128636,-0.030283224,0.06435755,0.06714093,0.023208749,-0.016405832,0.02283588,-0.02954899,0.02257805,0.034394916,-0.027200403,0.03418382,-0.07026203,-0.024340175,-0.06589097,0.059313327,5.611715e-05,0.0058995197,0.031986732,0.01227357,0.0230407,0.035008434,-0.023169624,0.020054378,0.036404323,0.065167606,-0.017424988,0.07762853,0.08674435,-0.10358162,0.0081084985,0.048435107,0.010456208,0.030578466,0.014668163,0.024333505,0.06844975,0.06590748,-0.046863195,0.01680338,0.012356485,-0.1355357,0.022680467,0.025927907,0.09863489,0.0932858,0.055384975,0.149639,-0.013111162,-0.012983809,0.12451863,0.010238338,0.030632677,0.07857522,0.029566048,-0.03370926,-0.0335803,0.05257928,0.018627523,0.06776621,0.030963583,-0.032876603,-0.0054261815,0.00038411512,-0.08212439,-0.13964231,-0.011224953,0.07847675,0.0018248621,0.050152615,-0.028107079,0.021112755,-0.014956875,-0.043874733,0.037730705,-2.7440116e-08,0.016835436,-0.043215115,-0.0028797358,-0.032569025,0.1082537,0.029274844,-0.06322655,-0.00832138,0.027290907,-0.044378243,-0.069392055,0.11280452,-0.0247217,-0.0029471337,0.040193122,-0.0184881,-0.018537665,0.008531184,-0.02000828,-0.02001042,-0.09281322,0.040700343,-0.08603653,0.00782066,-0.021631626,-0.042907514,0.022513077,0.008152095,0.06245898,-0.0063681444,-0.017067403,0.03774718,0.012939373,-0.013454773,-0.09230099,0.020793486,0.023567926,-0.08319125,-0.034701355,0.06798914,-0.0647825,0.02343552,-0.029937731,-0.051512476,-0.014426712,0.023618188,0.042766355,0.0020181641,-0.08167112,-0.033275638,0.020835578,-0.036751438,-0.0013008973,0.0057121366,-0.09511767,-0.032166805,-0.00702063,-0.07944446,-0.022837067,-0.070002005,-0.008757891,0.053681925,0.14084241,-0.0059665577 +1.14.13.128,A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida prefers NADH over NADPH. The enzyme is specific for 7-methylxanthine [2]. Forms part of the caffeine degradation pathway. ,384,1.0,-0.0355149,-0.009623125,-0.08940973,0.088868335,0.08202451,0.06761235,-0.055734526,0.05518712,0.040306717,-0.043854088,-0.03760708,-0.04782429,-0.04652395,0.05669945,-0.043573458,0.013858794,-0.021630393,-0.028374283,0.024170889,-0.020754946,0.051037155,0.06770055,0.045048814,0.013110612,0.016350914,0.042120896,0.044013135,-0.01378401,0.008005022,-0.01854587,-0.08486572,-0.040663835,0.04789352,-0.083753355,0.017273577,0.049090706,0.032932505,-0.00086283125,0.01386258,0.023349838,0.0029295033,0.0017880459,-0.035685442,-0.019236427,-0.03363398,-0.036418892,0.07108587,-0.01597108,0.008225065,0.003436383,-0.083477244,-0.0456986,-0.003997846,0.044238105,0.050056603,-0.01038598,0.049381364,-0.036689978,0.007946128,0.024914714,0.031966534,-0.07921147,-0.05200792,0.051413655,0.010994605,-0.032398574,0.05358248,-0.032263294,-0.02897098,-0.099353485,-0.061163124,-0.036490023,-0.014766758,-0.004881661,-0.034417953,0.03644239,0.03322933,-0.027048718,0.06803691,-0.010145903,0.0020893365,-0.01332815,-0.023736665,0.10129149,0.03372888,0.009593128,0.034017205,-0.01613453,0.0031278306,0.014195939,-0.06729178,0.027759818,-0.03395256,-0.04175143,-0.053877447,0.023269847,0.05085562,0.09356721,0.030719219,-0.0021870367,-0.01763248,0.085956,-0.042218097,-0.04901904,-0.0393588,-0.030872656,-0.028917685,0.103755645,0.09862621,0.024217991,0.024217982,-0.00066284975,-0.000740237,0.02772966,-0.0014018266,0.048599932,0.047749594,-0.03164611,-0.082423456,-0.013217316,-0.023768201,-0.031163797,0.031847633,0.021499166,0.006583369,-0.02249783,-0.1502493,1.0409113e-33,0.101580925,0.0332953,0.027613714,-0.049702704,0.037526958,0.024458267,-0.1066561,0.0497533,0.034528453,0.014087849,-0.020449648,-0.09703663,0.016803421,-0.020050101,0.036817692,-0.08509866,-0.04705519,-0.027669087,0.00065277534,-0.027397009,0.09059135,0.103916556,-0.018579384,0.03556523,0.03551929,0.03666381,0.033821974,0.014027267,-0.0046416437,-0.0015677982,0.02979634,-0.095157556,-0.13339598,-0.0563135,0.03555124,-0.061097723,-0.04229983,0.008281726,-0.00940441,0.08162077,0.018721258,0.070964664,-0.027425274,-0.057846457,0.08380561,-0.14255874,-0.028485462,0.1291363,-0.009376589,0.11288589,-0.04605994,-0.05187722,0.13730057,0.035838287,-0.081518605,-0.020186018,-0.031498734,0.03436526,0.03726931,0.041881233,0.07566675,0.03399881,-0.022184988,0.030357888,-0.0077204565,0.00028151207,-0.08680164,-0.039447308,0.03706018,0.019253004,-0.015561486,0.07678162,0.0028431388,0.0061401054,-0.0018216724,-0.11392866,-0.1292032,0.03995,0.060581908,-0.056293245,0.020278284,-0.06840076,-0.009060191,-0.00063697435,-0.07604113,0.03249266,9.768006e-05,0.0035091364,-0.08394905,-0.013344092,0.049505953,-0.041887723,0.012998769,-0.0117399795,0.00091254665,-6.5810033e-34,0.068021655,-0.07957828,0.10066207,-0.11297302,-0.0008280546,0.055004388,-0.0036230804,0.0078737475,-0.022141261,-0.06702882,0.08422492,0.032571886,0.063118584,-0.042595834,0.0048157917,0.017281901,-0.034843914,0.028496647,-0.00016555404,-0.030391583,0.006133219,0.04665299,-0.062287413,-0.00010916027,0.10544026,0.031850975,-0.046359368,0.06647965,0.04072615,0.08367773,-0.009150683,0.06616471,-0.062275242,-0.024954768,0.036491487,0.016449707,-0.030326111,0.02585092,0.02542583,0.06483515,0.015643895,0.014731154,0.019641863,0.09921371,0.045684297,0.072575614,-0.1956422,-0.018619888,0.04171594,-0.026572382,0.035731602,-0.041315723,-0.09279436,0.02887286,0.031585697,0.0018168626,-0.039850887,0.04738158,-0.06015837,-0.036466848,-0.008814045,-0.045594033,0.029759496,0.047134764,0.03449541,0.027859079,-0.05091707,0.089471534,0.015602719,-0.045479458,0.091216385,0.0065401495,-0.034161888,0.0035420335,-0.05458223,-0.02778679,0.012660162,0.025342662,-0.0089402385,0.03602206,-0.0014276003,0.0006897236,-0.043528594,-0.051969677,0.016027581,-0.025936875,0.043075237,0.014373361,-0.024364194,-0.0016152904,-0.053876232,1.9909909e-05,-0.029804723,0.046026137,0.013396282,-2.9475505e-08,0.02363667,-0.11036962,0.07277192,0.050260473,-0.005948685,0.009397779,0.03078926,-0.050130602,0.050382964,-0.028410327,-0.0049255383,0.059349965,0.033563964,-0.008782305,0.049542613,-0.04307954,-0.03352622,0.057942122,-0.020391572,-0.0053505106,-0.06112944,-0.053914677,-0.04703359,0.05133693,0.040608726,-0.10353508,0.022001607,-0.00893385,0.061741576,-0.06949515,-0.026119197,0.035244703,0.036068037,-0.023624882,-0.11059075,0.029288614,0.007748738,0.025179993,-0.076554514,0.030800596,0.007091282,-0.109957255,-0.08878736,-0.012100727,0.045573205,0.002663405,0.054857157,0.0038515266,-0.025811518,-0.026532523,0.055115987,0.051231135,0.059927233,-0.016160564,-0.07625956,0.053464107,-0.0099260155,-0.017938219,-0.024049548,-0.028737454,0.049490944,0.0035312204,0.14890319,-0.0192103 +1.14.13.129,Requires ferredoxin and Fe(II). Also acts on other carotenoids with a beta-end group. In some species canthaxanthin is the preferred substrate.,384,1.0,-0.02390839,-0.04259344,-0.09648121,0.031834874,0.07087275,0.021929335,-0.024214108,-0.015644573,0.005949353,-0.07339121,0.046926692,-0.061718285,-0.0419533,0.050759252,-0.013365131,-0.008499358,0.0027533069,-0.023496436,0.047196463,0.024645912,0.06932714,-0.014011627,0.017546155,-0.044008136,-0.038894717,-0.049180437,-0.051000204,-0.023616413,0.031727005,-0.08267485,-0.08647468,0.07168682,0.050995853,-0.052165393,-0.049798623,0.082959004,-0.061680283,-0.017496666,-0.025097676,0.0016245526,0.0020737678,-0.050394613,0.005174773,-0.008722694,-0.02335484,-0.08856756,-0.011043072,0.003947017,0.04241659,0.048034105,-0.06371004,0.017660795,0.010433335,0.008221188,0.016619874,-0.0019132395,-0.04776285,-0.004309054,0.026781315,0.009803488,0.063714065,-0.0219485,0.008520267,-0.034817897,0.045398034,-0.00716566,-0.038662985,-0.014453923,-0.034943882,-0.056844834,0.05882568,-0.011128313,-0.0161791,-0.055015594,-0.0064114598,0.048562273,0.0059727808,-0.03376613,0.012459471,0.0044217207,-0.011111662,0.049439102,0.015396186,0.06285185,0.059645254,0.05034381,-0.058287002,0.021468159,-0.12272538,0.07018201,0.033850484,0.022677451,-0.026077084,0.055417746,0.02344947,0.005389951,0.094838336,-0.08366849,-0.0029305124,-0.044273276,-0.03590918,0.011185609,-0.04814162,-0.033454597,-0.047064323,-0.008951425,-0.04415105,0.027010366,0.021367524,-0.017066734,-0.006434459,0.007467312,0.070915416,0.005309068,-0.021301052,-0.0042211716,0.002805596,-0.057976708,-0.06177063,0.06011873,0.00752706,0.041200206,-0.023370758,0.06715708,0.024656247,0.032380447,-0.05888718,8.540667e-34,0.08648859,0.0759835,-0.01103444,0.018681666,-0.015301722,0.011367517,-0.06488505,-0.06287008,-0.00506052,-0.09035698,-0.09310269,-0.05948616,0.01700691,-0.047037918,-0.010374887,-0.06815661,-0.023217352,-0.03842024,0.04890686,-0.017155096,-0.011776635,0.07412963,-0.06343928,-0.019545631,-0.014292685,0.064727664,-0.028644385,0.008241417,0.0028251356,0.0044683754,0.09663746,-0.08327488,-0.0682186,0.045218818,0.10573097,-0.0043906104,-0.008192727,-0.05159448,-0.14683726,-0.0002718623,0.009372752,0.11096577,-0.031517927,-0.026160983,0.07680385,-0.098239765,0.016659863,0.11784691,0.0450867,0.118992895,0.023638483,0.008960682,0.061034493,-0.056957204,-0.036466755,0.04322309,-0.01742815,-0.028451987,-0.04170766,0.05444335,-0.04234527,0.011777387,-0.013166384,0.013825378,-0.017704275,0.065138474,-0.10001548,-0.01891365,-0.044727575,-0.02051511,-0.037933815,0.013143741,0.06063906,0.057424698,0.018432753,-0.0156607,-0.044846646,-0.012599828,0.08643895,-0.052424163,0.035536148,-0.016018152,-0.017046843,-0.056600645,-0.030456422,0.02514147,-0.016595941,-0.04092146,0.06987303,0.053856857,-0.00078397035,-0.03784627,-0.023611343,-0.051719256,0.05533313,-2.4082494e-33,0.081527166,-0.114085004,0.058316533,-0.016383378,0.016609536,0.057951428,-0.06194331,-0.13213694,0.025848055,0.015494967,0.0040488094,0.028895194,0.043531965,-0.054348167,-0.00078392116,0.052329566,0.010520591,0.09050809,-0.00024418088,-0.061032258,-0.11000113,0.06760403,0.0013389282,0.05927385,0.044945244,0.04998182,-0.06829821,0.009722182,0.07029124,0.011141721,0.03662432,-0.06039007,-0.06908256,-0.07159127,0.04580255,0.054789133,-0.0876127,0.00909165,0.025443546,0.056894418,-0.0591336,-0.0063961227,0.03928765,0.09163429,0.005066636,0.03427942,-0.021175116,-0.017562415,0.010785145,0.024821185,0.024628596,-0.06453915,-0.050315212,0.018168407,0.039258327,0.021786034,0.12730293,0.07880523,-0.02260736,-0.04139008,0.053878676,-0.027525386,0.0018294279,-0.045904744,0.0154999215,0.002870781,-0.008637581,0.10488298,0.08337294,0.04254444,0.035722572,0.008658448,0.094270736,-0.0071982327,-0.009411964,-0.0046804193,-0.039474655,-0.025939247,0.016416784,-0.04021853,-0.034094542,0.07156718,-0.016741147,0.014210174,0.01995004,-0.03516624,0.066431604,0.0018583698,-0.0048036748,0.0043597193,-0.022806132,-0.019961797,-0.030400332,0.03649536,0.084177226,-2.9952094e-08,0.030981934,-0.0014488306,-0.0006162271,-0.08974513,-0.019890565,-0.039518643,0.008774728,-0.06913304,0.044988237,-0.05392427,0.045102645,0.082830384,0.07333874,-0.015704403,0.095947035,-0.088279866,0.08224548,-0.0038166123,-0.048866875,0.03265736,-0.18565626,-0.04285085,-0.13985348,0.00810042,-0.018426573,-0.09060241,0.06123868,0.004394748,0.06133548,0.033543218,0.041312173,0.018151756,-0.058014937,-0.057757705,-0.08698254,0.08009338,0.003031814,0.013471268,0.0138220405,0.003886905,-0.023532202,-0.009910574,-0.019966058,0.009713587,-0.047015674,-0.00038165768,-0.0119652115,0.01894728,-0.04405655,0.06677309,-0.050009,-0.09314809,0.026583297,-0.043883506,-0.064920925,0.07080306,0.07959403,0.038861107,0.07528116,-0.035979025,-0.05867863,0.07207487,0.15360431,-0.026494062 +1.14.13.130,A flavoprotein (FAD). The enzyme initiates the degradation of pyrrole-2-carboxylate. ,384,1.0,-0.02798497,-0.057365414,-0.05451144,0.013802025,0.12723935,0.03038462,-0.030939067,0.061642386,0.029619314,-0.04625004,-0.046526287,0.080830865,-0.11411652,-0.013835485,-0.08044066,0.030211763,-0.08544993,-0.0010176199,-0.023462145,-0.025585568,-0.023356883,-0.050010998,0.043285552,-0.003839075,0.0061794915,-0.018831186,0.017333778,-0.025828358,-0.05884801,-0.012794402,0.071324036,0.05566762,0.008998004,0.012000865,-0.020202894,0.05867131,0.003945416,-0.026259974,-0.04250352,-0.030673623,0.047608964,-0.019093903,0.0076115103,-0.013157375,0.061299898,0.02865975,0.017076762,0.039077908,-0.0006901913,0.040521417,-0.02403555,-0.014311775,-0.08432763,-0.0050569167,-0.014663497,0.047046766,0.021422222,-0.017853595,-0.05487826,0.018704295,-0.007858853,-0.019203387,0.028549742,-0.023964947,0.03469687,-0.05885938,-0.0099963285,-0.015642144,0.05910503,0.012355594,-0.039068602,-0.022598153,-0.03126565,0.034863878,0.035754412,0.022668978,-0.09419541,-0.046077576,0.07200176,0.0073871273,0.09712703,-0.038023356,0.09858043,0.052738573,0.03282062,-0.036964953,-0.014833688,-0.0034555288,-0.039286975,0.0673203,0.013875404,0.046910416,0.018548716,0.070065625,-0.052931607,0.07087438,0.037594877,-0.035195928,-0.091284126,-0.052446876,-0.03743942,-0.022445936,-0.016798204,-0.03347724,-0.04708355,-0.05610854,-0.03138343,0.031664595,0.0043219524,-0.034142055,-0.008797501,0.007091593,0.036509924,-0.05994724,-0.012743055,0.07254936,-0.010410618,-0.008527368,-0.027637007,0.029058421,-0.013471128,0.10940809,0.059283614,0.109567344,0.015976716,-0.026306262,-0.063099295,-8.06908e-34,0.02989447,0.011934197,-0.006024505,0.07681439,0.0055485214,-0.025793321,-0.05949232,-0.014659651,0.02323099,-0.03777308,-0.009584866,-0.07007636,-0.0052418374,-0.066362284,0.041498695,0.0070724823,-0.061449494,-0.018336412,0.067752354,-0.124787204,0.05942534,0.08091321,-0.00033614915,0.10410453,0.036445152,0.019411013,-0.04428171,0.05077987,0.028319407,0.020233339,-0.0056046066,-0.08198584,-0.119850546,-0.0047778403,-0.017147508,0.012043998,-0.09027032,-0.10573367,-0.08872777,0.082602836,0.0033323015,-0.07429946,0.0009238262,-0.031374034,0.016090337,-0.076147094,-0.053816877,0.13512103,-0.016167909,0.07613222,0.045876395,-0.057600945,0.08600365,0.1250528,-0.093716875,0.035375744,-0.03993876,-0.060942184,0.029980969,-0.01371282,0.049067717,0.048699882,-0.011246665,0.032821316,-0.070957616,-0.0055018645,-0.018374685,-0.05517619,-0.009369167,0.13328478,0.07410087,-0.02954849,0.07029259,0.029380856,0.08529465,-0.028734634,-0.06491128,-0.0010516298,-0.024843348,0.03911205,-0.03441427,-0.0028424123,-0.017926265,0.0005585662,-0.03764986,-0.010386079,-0.0102490615,-0.029819783,0.023248235,0.034391135,-0.0058090286,-0.08955698,-0.015110055,0.03536568,0.021971837,8.386013e-34,0.029879287,-0.07746647,0.047009964,0.07595945,-0.0018075258,-0.02271688,0.04425958,-0.047035053,0.05214558,-0.054010913,-0.0027748311,-0.08644849,-0.016771061,0.017625676,0.058253687,0.01885708,-0.069241576,0.0038034748,0.047869198,0.038034942,-0.064969406,-0.023748295,0.03661223,0.118051976,0.015011123,-0.023289075,0.03353972,-0.0637543,0.070415065,0.03924883,0.002076225,0.04669151,-0.054578774,-0.0073009604,-0.07781555,0.033579927,-0.0148827005,-0.00031063604,-0.024405183,0.03966581,-3.153645e-05,0.026573682,-0.009248893,-0.006062724,0.04852633,0.049444504,-0.017973667,0.06906863,0.085379556,-0.051485736,0.027485967,0.056962833,-0.004822176,0.035905577,0.04744379,0.060795076,0.059701048,0.04220145,0.013178621,0.029306838,0.016661016,-0.10552087,0.0048522362,0.023414535,0.064314514,0.071670696,0.05137365,0.14614375,0.016063156,0.016810834,0.15944706,0.021036034,0.056578785,0.11395477,0.0052543655,-0.011942642,0.005307816,0.10026416,0.045548655,-0.03210236,0.03307286,-0.034955792,0.027011774,-0.020058945,-0.08515597,-0.14394917,0.010574117,0.08084849,0.023805821,0.020437606,-0.02024259,-0.028954856,-0.014413613,-0.021799952,0.028175741,-2.3921835e-08,0.025397345,-0.049907897,0.01920182,-0.044863027,0.051490646,0.016671179,-0.00068490504,0.017321793,-0.015276822,-0.04627376,-0.061033364,0.060176022,-0.020791158,-0.021422768,0.027031858,0.0063590254,-0.013311084,0.035542086,-0.019429604,-0.010968622,-0.091996565,0.03583159,-0.13087335,0.01519569,-0.06169625,0.0120502515,0.006882006,0.0010755731,0.046943877,-0.008255871,0.020971525,0.016872646,0.078600764,-0.035561793,-0.108954184,0.025420513,-0.0022241336,-0.061217386,-0.042855084,0.0788369,-0.084282964,-0.016123341,0.030507594,-0.08260178,-0.017329365,-0.018114127,0.024996666,-0.013107181,-0.050959215,0.0068969447,0.048225153,0.0073041962,-0.04503964,-0.0052538826,-0.07540107,-0.017529804,0.003734195,-0.06753684,0.007178423,-0.15343158,-0.03375405,0.041128974,0.11547672,-0.0035841 +1.14.18.3,"Contains copper. It is membrane-bound, in contrast to the soluble methane monooxygenase (EC 1.14.13.25).",384,0.99999994,-0.05273197,-0.0120110465,-0.0530034,0.0027233083,0.098967835,-0.007922492,-0.0019701042,0.074912585,-0.0059647164,-0.1062764,-0.02433652,-0.11949496,-0.03540997,-0.028600976,-0.026855992,-0.09509943,0.028612062,-0.10727822,-0.049488593,-0.012785,0.032045234,0.05202392,0.03047692,-0.06069483,-0.047372624,0.081292264,-0.025833407,-0.073193334,0.03140813,-0.029546563,-0.054142542,-0.022267682,0.026582547,0.030311007,0.029253801,0.038535245,-0.040529598,0.005138731,0.038280033,0.0100392485,0.008598987,0.006823215,0.10110487,-0.0011268521,0.008375256,-0.028286532,0.06221883,0.0022311837,-0.043961912,-0.044326186,0.034906387,-0.0063809757,-0.063648306,0.10998624,0.07581215,0.01121284,-0.01884543,-0.067149326,-0.08441177,-0.031234395,0.03252071,-0.0153939305,0.019871775,0.06529811,0.00066844263,-0.014096395,0.07222814,-0.03846915,0.04137579,-0.043512687,-0.048546035,0.010202167,-0.056523036,-0.01587761,-0.034218863,0.13021438,0.17679587,-0.07536952,0.07938481,-0.04111714,0.0038438288,0.085599095,0.014386019,0.027984004,0.025807293,0.03206761,0.026802562,-0.053459592,-0.07575108,-0.034966163,0.027121833,-0.0076914956,-0.015642168,0.005524311,-0.06904102,0.020572774,0.05861161,0.033177175,-0.04358635,-0.05209385,0.009895639,0.08609912,-0.010786278,-0.05464416,-0.08249311,0.019839292,0.006241954,0.09127761,-0.034418717,0.009345236,0.04743843,-0.010940465,0.019656207,0.040561125,0.09886794,-0.030639758,0.040421057,-0.040759336,-0.032203205,0.078535855,-0.069391444,-0.018556688,-0.020113995,0.026269296,-0.008480258,-0.03701292,-0.02175881,-3.3361937e-33,-0.011270993,-0.06309535,0.055785205,-0.0876794,0.033306517,0.061202865,-0.035935994,-0.014919056,-0.063462704,0.061070323,-0.023196144,-0.006182477,-0.0211973,0.046110835,-0.066958435,0.035768636,-0.07475185,-0.019393954,0.03657495,-0.060869694,-0.047467146,0.05281598,-0.010107358,-0.02099898,0.025795493,-0.100777954,-0.037408456,-0.04651978,0.035740238,-0.035090946,-0.031129293,-0.02549714,-0.012454542,0.06141372,0.014556586,0.016944319,0.024432657,0.006974934,-0.050833225,0.069785535,0.0022429405,0.034643676,0.042610984,0.0007993433,0.028042726,-0.12996411,-0.13161658,0.11871736,0.001956794,-0.020297807,0.015124481,0.00891637,0.05429244,-0.057729598,-0.0016089716,-0.041912332,-0.0014710494,0.058875524,0.035249177,0.06665333,-0.010591019,0.019798193,-0.06286858,0.06692061,0.062884666,0.0809613,-0.055332717,-0.040916823,0.017434426,0.058765743,-0.07164172,0.0027967305,0.0745816,0.03471185,0.050809205,-0.0441809,-0.015363222,-0.026295112,0.09136418,0.11501375,-0.04560402,-0.046072908,0.057979267,-0.02319384,-0.08753375,-0.042504005,-0.0398878,-0.03276481,0.052602526,-0.005294992,5.4220935e-05,-0.038626075,-0.08782213,-0.069054835,0.0031544662,3.1439448e-34,0.06710681,-0.010048858,-0.0077089956,-0.047038663,0.024377324,0.01646529,0.0020555842,0.0026561082,0.06123673,-0.047256503,0.14165281,0.014986412,-0.0099119395,-0.029270768,0.058881667,0.029110366,-0.0921714,0.10328378,0.024273034,0.04417192,-0.05305961,-0.016431412,-0.037980128,0.09293445,-0.000525342,-0.017535957,-0.08193333,-0.03717347,0.014955258,-0.015333597,-0.04081842,0.025603203,-0.093397334,0.018623382,-0.112394735,-0.039726492,0.0037791058,-0.0352913,-0.009965733,0.08280704,0.0090123955,0.023113342,0.022897385,0.05137805,0.0050946306,0.07355705,-0.03839571,-0.059925705,-0.039926883,0.041120004,0.04988878,-3.9928786e-05,0.020222535,0.06350044,0.05995752,0.083165035,-0.0063616335,0.015000594,0.04884888,-0.043381363,0.01443427,0.0067428974,-0.040368024,-0.027825462,0.010717703,-0.008671149,-0.0585072,0.070777334,0.041602205,-0.0139228655,0.07029407,0.030075947,0.068073794,-0.05960022,-0.05155825,-0.01447047,-0.005898161,-0.03670891,0.038648512,0.053513795,0.040440325,0.08168816,-0.013703048,-0.029197346,0.029861761,0.024038808,0.043332558,0.03879425,0.024281066,0.017422896,-0.031637765,-0.07669613,-0.074863926,0.028570484,0.07184874,-2.8339747e-08,0.0271047,-0.023610987,0.0013849107,-0.037702512,0.0014133116,0.14581765,0.11958429,0.019575445,-0.018592196,0.05386529,0.017314076,0.052812297,-0.026400862,-0.059349835,0.00181598,0.032708455,-0.05367058,-0.04381245,0.015779315,-0.053387586,-0.034305822,-0.042132508,-0.020216987,-0.01807249,-0.013208747,-0.028666776,0.00028796648,0.010940506,-0.08993579,0.008825271,-0.027753875,-0.036607485,-0.0024354106,-0.0458237,0.008356665,-0.004512144,0.048372388,-0.04721808,-0.08348464,0.05066262,-0.025740255,-0.024325356,-0.007326687,-0.062111054,0.063278295,-0.009180544,-0.019236,0.09663743,0.0019233256,-0.036895137,0.0065827626,-0.05204931,0.0057522566,-0.06229816,-0.040085945,0.026830804,-0.046681195,-0.018173674,-0.07037676,-0.012016065,-0.017369177,0.044858225,0.19367923,-0.024610749 +1.14.19.7,"Contains one non-heme iron centre per monomer [1,5]. FMN is required to mediate the transfer of reducing equivalents from NADH to the active site iron [1]. This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species.",384,1.0,0.008505401,-0.029097885,-0.14620426,0.023501607,0.038672347,-0.015946914,-0.012045103,0.107134335,0.04849106,-0.041909333,-0.012788826,0.01293722,0.03447644,0.07417995,-0.063762136,-0.02726225,-0.07466101,-0.025025524,-0.013866124,0.019875463,0.02394544,0.070784934,0.054542158,-0.030784149,-0.048003763,-0.062274415,-0.030400766,0.027743418,-0.037470546,-0.03994657,0.08537017,0.03946465,0.05674916,-0.02457001,0.04942192,0.044986248,0.0025076224,-0.051328253,0.09287818,0.05186284,-0.046532415,-0.05152006,0.002524237,-0.040739313,-0.033253714,0.024957748,0.05563782,0.012568607,0.06655117,0.054722454,-0.04524628,-0.03451296,-0.06642969,0.100524575,0.09624979,0.0807267,0.007904186,-0.08017845,-0.043566704,0.0003476787,0.038512412,-0.012097744,-0.062487964,0.021310763,0.003425969,-0.03328207,0.030993816,-0.073215544,0.001486809,-0.006145747,-0.03355982,0.0023020539,-0.026528839,-0.055100698,0.01951008,0.04257896,0.017184002,-0.014874962,0.0030177303,0.002897141,0.0067284578,0.01762734,0.078195296,0.09731625,0.031989526,0.0058741136,-0.017347245,-0.021161182,-0.0027680714,0.11172045,0.03331632,0.012022507,-0.012317476,-0.0687834,-0.061330598,-0.0050878325,-0.01060591,0.0722152,0.022942513,0.047766645,-0.03870092,-0.0036825058,0.008483523,-0.014906805,-0.03905465,-0.006096897,0.036260877,0.11381094,0.024639012,-0.036016233,0.022161512,0.007926191,0.02133231,-0.06819555,-0.035743333,0.070121855,0.09036352,-0.0684782,-0.052798647,0.024525872,-0.00039631233,0.07447663,0.002832092,0.0427861,0.0037611006,0.0166676,-0.10464233,1.8631306e-33,-0.0052548638,0.11900785,0.05618222,-0.06393289,0.012637768,0.0053465995,-0.10153446,-0.060407203,0.02581249,0.0004652139,-0.08985284,-0.055854518,0.0013509041,-0.00903306,-0.051652085,-0.11289944,0.03451862,0.01907811,-0.004178413,0.0030495904,0.12267935,0.014432972,0.027459217,-0.019956011,0.051233172,0.07003379,-0.0438361,0.0720923,0.044595182,-0.014991569,-0.02874565,-0.03574281,-0.058944125,-0.043198016,0.08527481,-0.054893672,-0.023382476,-0.03043049,0.010521977,0.036450434,0.0074716485,0.04692217,-0.05688949,-0.01356658,0.11101208,-0.05921319,-0.11447491,0.07456744,0.031774595,0.089973144,0.04104231,-0.019800555,0.05151686,-0.022603314,-0.038360786,-0.009265226,-0.010006088,0.019217888,0.052092742,0.055860564,0.024243442,-0.01517604,-0.022738412,0.034190804,0.07767858,0.03593271,0.0019937954,-0.004937017,0.03705336,0.06695587,-0.053843394,0.034596294,0.054288443,0.010847807,0.015628217,-0.025115278,-0.084108464,-0.04484157,0.05704844,-0.003531927,0.0066757714,-0.0013533043,-0.08849799,-0.034453552,-0.047430366,0.031225296,0.0062492746,-0.07286221,0.0021967336,-0.007663924,0.007369667,-0.11214464,-0.04965641,-0.061860763,0.0090066,-2.7550856e-33,0.05761,-0.034831703,0.030416649,-0.052403074,-0.080353744,0.08411031,-0.020592995,-0.021519162,0.0034756956,0.041965816,0.088042416,-0.024094922,-0.053265113,-0.094448715,-0.05248045,0.009716397,-0.0073345504,0.05763611,0.02846532,0.022726288,-0.021458494,0.06338237,0.008236325,0.029747952,0.041270588,0.004452666,-0.06612831,0.07004255,0.05539321,0.0975432,-0.03170295,-0.06482576,-0.037356243,-0.08791812,0.005738918,0.047954727,-0.027217047,0.08068736,0.05740232,-0.0074839406,0.06415026,-0.045647077,0.051521268,0.10521939,-0.037154675,0.0549624,-0.18768786,0.017096836,0.047153305,-0.041598916,-0.04060508,0.02903044,-0.05141416,-0.002826151,-0.0046347403,-0.02145359,0.046056096,0.027964782,-0.041974038,-0.031445015,-0.03405934,-0.062104143,0.011507753,-0.027668001,0.08479373,0.029959941,-0.03110951,0.09413319,0.055597648,0.006144119,0.026860507,0.04615323,0.05183587,-0.024678681,0.041999895,0.011972066,-0.0047944477,-0.0059118797,-0.028797027,0.104027785,0.015028666,-0.009415737,-0.04866079,-0.06191895,0.0066501605,-0.06371784,0.06480602,-0.0014487023,-0.027706005,-0.05736225,-0.0079856645,0.0064749094,0.024885172,-0.05978527,-0.05014682,-3.6122593e-08,-0.0059061474,-0.06302893,0.017747937,-0.054814,0.003946565,-0.023304412,-0.041642625,-0.07262217,-0.0421717,0.022948077,-0.0147694945,0.13314398,0.0017645229,-0.042337433,0.01687665,-0.03904628,-0.039840817,0.0321256,-0.017246049,-0.051004704,-0.08495457,0.03719915,-0.07671695,-0.0067858067,0.048365884,-0.07078216,-0.00801103,-0.043344773,-3.178111e-05,0.022930145,0.069859706,0.01687661,-0.031806618,0.007479765,-0.13402988,-0.050014846,-0.08474389,0.017359896,-0.052034684,0.026845416,0.015227034,-0.032960504,-0.049060628,0.019523568,-0.09300675,0.026325097,0.0053049903,0.038505476,-0.04774226,-0.032769177,0.08351809,0.031884797,-0.0072264876,0.00036134478,-0.1295525,0.053852264,0.031078065,-0.0105314,-0.013600886,-0.038450114,-0.033356767,-0.053269427,0.14727163,-0.055166606 +1.14.99.42,"The enzyme, characterized from the plant Crocus sativus, acts twice on zeaxanthin, cleaving 3-hydroxycyclocitral off each 3-hydroxy end group. It is part of the zeaxanthin degradation pathway in that organism, leading to the different compounds that impart the color, flavor and aroma of the saffron spice.",384,0.99999994,-0.04327334,-0.05869977,-0.108800374,0.032727733,0.12974314,0.07601544,-0.061424702,0.011254523,-0.011106094,-0.08722049,0.026930042,-0.035086162,0.08381804,-0.05114044,-0.0734245,0.02581506,-0.053411618,0.020275423,-0.029887635,-0.09022628,0.08535727,-0.0096535375,0.012752045,0.027206939,0.07152561,-0.0325219,-0.025924897,0.014639337,0.01808293,-0.0025437307,0.04053062,0.080644004,-0.0029980934,-0.012956298,0.025326129,0.056550644,-0.074933425,-0.066800006,0.075294256,0.046253745,0.06807957,0.020063367,-0.020799093,-0.07263455,-0.008658259,-0.043347616,-0.08226139,-0.019266393,0.010339279,0.040697105,-0.029239884,-0.0473175,-0.10167449,0.06762141,-0.044846024,0.007950487,-0.09448632,-0.0138364155,0.036098167,0.07081687,0.025455633,-0.025529433,0.02809969,0.020674478,0.009962346,-0.06896769,-0.0828586,-0.07723041,0.022222446,-0.013317394,-0.01844579,-0.037365735,0.024817916,-0.007512226,0.015224862,0.017138746,-0.01608508,-0.03435349,-0.02398972,-0.065165,0.023525767,0.027765691,0.045746915,0.085998416,0.06409281,0.033185415,0.039421286,-0.034734305,0.00344436,0.014764266,0.06642116,-0.017088264,-0.0050418167,-0.07241363,-0.022058032,0.06439217,0.024991963,-0.048776235,-0.018939685,0.0069748173,-0.026469605,-0.022647271,-0.032338135,-0.08126,-0.04234374,0.020712966,-0.01654504,0.030553585,-0.054866143,0.010699452,-0.045865297,0.0060821017,-0.007870175,-0.07636145,-0.03567778,0.10911179,0.07173995,-0.001566682,-0.11288191,0.012383724,0.030013343,-0.087573,0.012239939,-0.011740617,0.0339099,-0.002206365,-0.05036628,2.6879418e-33,-0.04410242,0.014491945,-0.030316314,-0.068086416,-0.0037539785,-0.017151762,-0.0888402,0.0819639,-0.07933506,-0.044651743,-0.061644044,0.04787241,-0.023581397,0.046155043,-0.05611885,-0.049238287,0.016937308,-0.046084043,0.018207077,-0.051961094,0.013314293,0.06285615,-0.021391015,0.0034339072,-0.08391836,-0.053925183,0.0050962484,0.06418168,-0.025075879,-0.003188351,0.078080505,-0.023975767,-0.08020354,0.049174964,0.008993487,0.071505494,-0.03726992,-0.08640854,-0.05238409,0.04239777,-0.007822644,0.08208982,0.021046745,-0.034359314,-0.019506566,-0.0114885755,-0.0011174183,0.05259106,0.12232929,0.017687356,-0.013484275,0.021545578,0.11768069,0.0064489637,-0.07797438,0.05435026,0.041399393,-0.057520032,-0.00017413298,0.036250327,-0.035835948,-0.043731563,-0.04403394,0.01711931,-0.006256809,0.03829339,-0.1283743,-0.056496255,0.0338452,0.0132969925,-0.055002797,-0.0032125297,-0.035266124,0.025978401,0.02151416,-0.027312139,-0.014416101,0.022230277,0.03311701,-0.01706497,-0.02082994,-0.012026312,0.041257225,0.032943103,-0.065601304,-0.06848276,-0.103554934,-0.006973241,0.07398518,0.008260517,0.056853488,-0.07326554,-0.009459723,0.045352552,-0.026223257,-3.0622761e-33,-0.028146857,-0.04153142,0.061768923,0.038148496,-0.027347447,0.103896864,0.022562474,-0.016091423,-0.02733407,0.04180055,0.10434596,0.048913598,0.0067526246,-0.08353929,0.044444624,0.062040307,0.10791593,0.09008277,0.008249248,-0.02162247,-0.048229244,0.10642876,0.005491979,-0.07005313,-0.027462116,0.06900166,0.063618734,-0.008930823,0.030101972,0.07868653,-0.02282008,-0.07369337,-0.09106042,0.04626446,0.024490876,0.0049169604,-0.012202244,0.022222169,-0.067110784,0.03890811,0.0548903,0.023533707,0.02111102,0.07894136,0.11115105,0.018440384,-0.053997733,0.09847342,0.0010160138,-0.015773332,0.032158032,-0.023449916,0.008774538,0.01858186,0.057142753,0.048219074,-0.00656827,-0.020966394,-0.062570184,-0.026492573,0.025912946,0.013944471,-0.076080926,-0.004606009,0.031627934,0.00432918,-0.017291045,0.024421409,-0.00879913,-0.033144,0.060601078,0.028185638,-0.005262914,0.01341981,-0.037359837,-0.040447056,-0.07083715,-0.04316842,-0.055880778,0.036886998,0.051502407,0.006880396,0.029474035,-0.037617728,-0.0640981,0.017061893,-0.04151701,0.11999283,0.12633774,-0.07220366,0.023780866,0.03853986,-0.05434567,0.060735386,0.08828818,-3.825929e-08,-0.038953036,-0.058324978,0.09133176,-0.01576321,0.015923219,-0.06296579,0.018848222,-0.02245107,0.06608714,-0.008944091,-0.07328477,0.107845664,0.011259114,-0.033028167,-0.011014081,0.0504451,0.017190423,0.060198024,0.019296372,0.09356558,-0.07415047,-0.04932827,-0.030830791,0.0028945145,-0.0010333244,-0.07944996,-0.0008169219,0.11253104,0.019835573,0.007498412,0.07126207,-0.025600517,0.016818056,-0.02063333,-0.09288449,0.018191624,-0.041339893,-0.02597209,0.018882869,0.033301722,0.059270676,0.0012765824,0.00082594366,0.0013829826,-0.024301633,0.02653749,-0.0016140307,-0.021635452,0.016924758,0.052920267,-0.01601438,-0.07482312,-0.022973478,-0.013918093,-0.0063802125,-0.14705187,0.021906925,-0.051114395,0.0164604,-0.06324244,-0.007655416,0.074078426,0.14168973,0.020880463 +1.14.99.43,A heme-thiolate protein (P-450).,384,1.0,-0.04221235,-0.009648528,-0.02017015,-0.00931061,0.049380444,0.028281422,0.05082566,0.14506581,-0.008442203,-0.0073699877,-0.033683497,-0.002747442,-0.10278858,0.021604793,-0.017335286,-0.032472603,-0.02056054,0.00022760473,-0.015948651,-0.10800422,-0.025060132,0.08815963,0.006413548,0.027355991,-0.045173433,0.007270301,0.07252466,0.057117477,-0.05330815,-0.061448153,-0.057344925,-0.05724848,0.018921748,-0.006857029,-0.0031842932,0.08840422,-0.0854333,-0.078127295,-0.0044417516,-0.08637306,0.1555069,-0.06545876,-0.083621874,0.005624206,-0.022200247,0.024814066,-0.026565667,0.09515464,0.027438747,0.05874837,-0.0037979702,-0.061781865,-0.04374357,0.06549257,-0.075458676,-0.008766182,-0.00028054934,0.060313947,0.023840137,-0.050121732,-0.050617512,0.052132256,-0.00804881,0.00071042136,0.026664583,-0.065538384,0.018666003,-0.002360214,-0.03303768,-0.016347144,0.02496965,0.00019709255,-0.020747708,0.083712116,-0.039207116,0.058749124,-0.033110235,-0.032901723,0.019486116,0.043539017,0.03288101,0.08326413,0.010980658,0.12573285,0.014322802,-0.0013771073,-0.04264829,0.0644641,-0.08331019,-0.08766872,0.007898977,0.026064927,-0.031199204,-0.0061640693,-0.08990097,0.059606615,0.014524434,-0.015040049,-0.007652888,-0.011238132,0.025008326,0.026234604,0.019135987,-0.08928119,-0.05857144,0.016341835,-0.026795687,0.0403539,0.096842356,-0.05533724,-0.003418714,-0.022388553,0.054909524,-0.056431692,0.003014255,0.074786305,-0.060456518,0.021530084,-0.001904319,-0.059161186,-0.045742348,-0.011181956,0.034301665,0.011839282,-0.08047748,-0.045,-0.07254012,-2.9011687e-33,0.063963324,-0.027773501,0.04188613,0.043995306,-0.014474557,-0.035767384,-0.079433635,0.048410207,-0.015930457,0.020445008,-0.03724342,-0.1373785,0.028635459,-0.04921327,-0.009827529,-0.08998615,-0.062630095,0.059913445,0.014023042,0.014981314,-0.0857457,0.060199924,0.019215401,0.045136318,0.044165615,0.056131,-0.013493619,-0.05069744,0.038260862,-0.0030557772,-0.038683932,0.005991535,-0.0015870526,-0.07829867,-0.005421769,-0.0162751,-0.0011071806,0.0032146566,-0.043319117,0.029215747,0.070932984,-0.0048818695,0.021437747,-0.04571358,0.06874848,-0.05734012,-0.07363238,0.0142707415,-0.026412172,0.019334642,0.059225455,-0.06748924,0.12578627,0.0409374,-0.071483746,-0.01311389,-0.009784689,0.061642643,0.022910662,0.045613896,0.14500454,0.05281952,-0.047341656,0.047523607,-0.029708162,0.06007201,-0.084510975,-0.027366078,0.03088916,0.093701735,0.008384913,0.014038933,0.066877626,-0.07039494,0.016461588,-0.023371123,-0.018623244,0.085822254,0.03712672,0.01657677,0.030846354,-0.03596439,-0.06002075,0.031995885,-0.034858465,-0.018043533,0.065693155,0.038554598,0.035675257,-0.007308921,0.09198755,-0.078670226,-0.028421057,-0.0042433664,-0.04158034,2.3907873e-33,0.09171293,-0.08408139,0.035043634,0.0057563065,-0.008840143,0.056321014,0.03266054,-0.016622847,-0.07005278,0.00021091118,0.16136502,-0.03584653,-0.019767739,-0.02722011,0.02781738,0.06861505,-0.061115406,-0.028284293,-0.0133021055,0.053081166,-0.030351482,-0.024467915,0.03476198,0.023846004,0.034980673,0.046600603,-0.009897105,-0.022000184,0.066779755,0.019258816,-0.028094884,0.023276312,-0.08685656,-0.05301216,-0.069006264,0.0032044365,0.061897878,-0.013146382,0.011687507,-0.017025886,-0.02379772,0.06409712,0.05674334,0.072550625,0.033551183,0.11180539,-0.023604453,-0.06598146,-0.037461895,-0.014870921,0.02652465,-0.012727512,-0.03726898,0.029868832,-0.059864625,-0.031067729,-0.033392753,0.04961544,-0.061697435,-0.07667477,-0.046043087,-0.0009920463,0.03185487,0.07085238,0.007401088,0.06537194,-0.06397477,0.029094659,0.029552551,-0.010131797,0.0087106535,0.0019754502,0.079371616,0.044309884,0.05070652,-0.005340709,0.03843763,0.008248569,0.06742529,0.028758788,-0.074692674,0.019253552,-0.11023804,-0.04982176,0.02702372,-0.021198053,-0.040231217,0.09081726,0.032232016,0.045944702,-0.06535328,0.030491825,-0.03797275,0.06847845,0.0770187,-2.1406224e-08,0.0047777737,-0.11102419,-0.043668676,-0.014567831,0.009202394,0.03573378,0.037278786,0.024634257,0.032754526,0.006918173,0.00732004,0.021158783,-0.028567655,-0.025272809,0.012125739,0.0031360595,-0.007301259,0.02946143,0.03074888,-0.034440737,-0.033398546,0.030336311,0.02779702,0.0141215045,0.02496579,-0.052454956,-0.04278036,-0.04764432,0.016025875,-0.0268586,0.0055533955,0.08351395,-0.043546412,-0.03571274,0.114147194,0.06269374,-0.03799958,0.0231264,-0.049985632,0.004726395,-0.011317468,-0.04008734,-0.072842285,-0.05897413,0.026654657,-0.022551144,0.05824101,0.08143541,-0.0631007,-0.05374147,-0.014524924,0.004303397,-0.015387938,-0.06658767,-0.12861969,0.00996711,0.035502452,-0.06977798,-0.03284972,-0.075329885,0.006401907,-0.024028866,0.1630482,0.00017107672 +1.14.99.44,"Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group.",384,0.99999994,-0.04308102,-0.0829131,-0.071622096,0.027036315,0.008470586,0.065507926,-0.062318675,0.037676483,0.00850289,-0.03284952,0.054168068,-0.076206364,-0.049389523,0.013214432,-0.01270393,0.09158339,-0.113211684,0.0033010845,-0.046780907,-0.060533572,0.0121433325,-0.040709566,-0.007867579,0.00820176,0.06755438,0.00014233252,-0.017116902,-0.076388955,0.0035155187,-0.020994391,0.0029210201,-0.012220053,-0.00917425,-0.04101101,0.06300221,0.08278416,-0.113392964,-0.053669684,0.032198925,0.064872995,0.01443085,-0.05285241,-0.036171604,0.027537784,-0.01722406,-0.00043347184,-0.018444989,0.03703597,-0.07877299,-0.009565667,-0.004219962,-0.05388691,-0.060536973,0.007291189,-0.018346276,-0.0003338199,-0.08688951,0.0412774,0.06375363,0.03025485,0.10354243,0.03701984,0.0046391664,-0.009145049,0.06162545,-0.06419521,0.0072033885,-0.055248864,0.06470363,-0.07137554,-0.024654537,-0.08363274,0.019730432,-0.023994816,-0.008231726,-0.011934102,-0.04264995,-0.027465383,-0.03895651,-9.9250436e-05,0.052477013,0.058444522,-0.0066849138,0.1261052,0.107288174,0.024337692,-0.025987748,0.023416087,-0.016844323,0.06146235,-0.031502746,-0.022209464,-0.13046584,-0.033770382,-0.066485375,-0.008439166,0.08067259,-0.06679831,-0.027718555,0.00046245373,-0.008328333,0.084149785,-0.0016028882,0.025687806,0.015603213,-0.00760023,0.04481432,-0.0025517195,-0.020512518,-0.0027093897,-0.027171884,0.068833224,-0.026444137,-0.045072377,-0.05025199,0.108593054,0.032416258,-0.04948916,-0.02831079,-0.009820048,0.009531146,-0.011722262,-0.010843454,-0.01645166,-0.056093145,0.053559132,-0.119027846,4.5384033e-33,0.04041972,0.03205956,-0.01162341,0.029099295,0.038741518,-0.035902966,-0.04743833,0.020812752,0.035954718,-0.08466258,-0.060587004,-0.013436617,0.0812758,0.0072631496,-0.021635598,-0.0075310576,-0.047818158,-0.023206932,0.049467668,-0.076295346,-0.015813265,0.012863818,-0.066825025,0.039458532,-0.015921494,-0.0013832822,-0.061183102,0.051395334,0.017699488,-0.008872434,-0.0048001423,-0.015943438,-0.060360268,-0.046821784,0.11660289,-0.001776552,-0.016057864,-0.1082135,-0.022878133,0.048523452,-0.027660305,0.06579364,-0.0076798163,-0.034631915,-0.031144911,-0.0013437654,-0.012160901,0.0794832,0.04928079,0.01347057,0.084013216,0.003682954,0.023716258,-0.02180717,-0.033555623,0.0519756,-0.017925717,-0.049730286,-0.004025741,0.043579243,0.03112898,0.038925577,-0.0063995896,-0.026362656,0.053034004,0.045880925,-0.09682488,0.01576206,-0.008375203,-0.020736914,-0.060244754,-0.037348766,0.03976752,-0.031845566,0.041438565,0.06294598,0.008396323,-0.06361789,-0.024652857,-0.07966509,0.073785596,-0.043875404,0.08075321,-0.09484111,-0.022887556,-0.025035111,-0.019550715,-0.07132969,0.013085608,0.023584004,-0.009414615,-0.08158708,0.015471694,-0.039922677,-0.013000777,-5.0861403e-33,-0.024895318,-0.060432177,0.026919194,-0.056255944,0.017299408,0.038819816,-0.02688481,-0.09384006,0.007969116,0.028687455,0.056561872,0.062130246,0.01079592,-0.019258618,0.014055877,0.033243563,-0.01847041,0.14642863,0.026511809,0.06488215,0.030588735,0.10959783,-0.061572343,0.017795287,0.010129642,0.076965556,-0.028907182,-0.020581208,0.079979435,-0.023299892,0.008757276,-0.040279653,-0.0514474,-0.01769821,0.04468565,0.09476925,-0.08471689,-0.014717426,0.024934608,0.02698954,0.019186264,-0.038931005,0.022151642,0.10351706,0.048481185,0.0280267,-0.09718612,-0.016581895,-0.05783039,-0.011225765,0.11748034,-0.01297831,-0.022494683,0.03556456,0.048544616,0.08440598,0.10266326,-0.07080117,0.0059540947,-0.03527329,-0.01719371,0.008835479,-0.030893615,-0.06920263,0.0066471524,-0.033155613,-0.02752449,0.10915671,0.0666083,-0.008858076,0.11633544,0.04467318,0.036227107,-0.03699387,-0.06494067,-0.053657997,-0.0402616,-0.023285346,0.0184593,-0.020331763,0.03189688,0.06116577,0.06535787,-0.05519438,-0.04494538,-0.0033178453,-0.02325598,0.0496501,0.005644061,0.05733578,0.0005433117,0.023495292,-0.012079107,0.16439968,0.119989395,-3.663709e-08,0.031570427,0.02018127,0.05227958,0.02530953,0.017559292,-0.09542668,0.013737598,0.033523306,0.017835371,0.018338248,-0.01831426,-0.0046218345,0.04559861,-0.050808106,0.029262545,0.0131076,0.019668628,0.04926735,-0.049509443,0.025599424,-0.049578656,0.01526233,-0.02364393,0.029393928,0.036305945,-0.09646038,0.039003897,0.10216616,-0.033547137,-0.0025753113,0.06690594,0.04565358,0.014370879,0.0019362641,-0.093846135,0.035311863,0.030475866,-0.038189873,-0.07864085,0.0015105958,-0.037810456,-0.076183334,-0.0567126,0.056060538,-0.05788688,0.0093577625,-0.05820645,-0.029693678,0.008826332,0.078906536,-0.02075305,0.0005837872,-0.022260455,0.05388332,-0.07675958,-0.020594092,-0.023080941,0.029355459,-0.031070972,-0.09177655,-0.051425587,0.11750844,0.16886045,-0.006924107 +1.14.99.45,A cytochrome P-450 heme-thiolate enzyme. Also acts on zeinoxanthin to give lutein. ,384,1.0,-0.06286565,0.0219655,-0.026638996,0.025938291,0.06618368,0.0021277952,0.034496948,0.13776945,0.022609962,0.011269381,0.029673526,-0.0018760653,0.0054865256,0.030763263,-0.015494684,0.06435103,-0.013959449,-0.016975116,-0.030763587,-0.081039116,0.021517858,-0.0066430587,0.030312225,-0.0056789303,-0.048256043,-0.034000598,0.05878032,0.06586993,-0.05649953,-0.016532874,-0.038898427,0.047662895,0.010461348,0.0022869734,-0.028102608,0.09747148,-0.091400765,-0.04960343,-0.0049440158,-0.03849801,0.064327754,-0.019733397,-0.08652638,0.0153968455,-0.025674496,-0.039174803,-0.044400875,0.048931032,-0.033767145,0.023609491,-0.03409724,-0.039500155,-0.022559656,0.06664017,-0.06105492,0.029961886,-0.037002925,-0.012390804,0.015878802,0.011960477,-0.037819766,0.05368113,-0.044198494,-0.028818848,0.021376396,-0.06861482,0.005113807,-0.04303036,-0.0702337,-0.05155296,-0.02294361,-0.037365805,-0.026708875,-0.01040616,-0.062897526,0.026502445,-0.039225046,0.0079603465,8.834328e-05,0.0180835,0.036641892,0.032322016,0.04156188,0.084799975,0.08989031,0.043039575,0.026890276,0.06583094,-0.082743116,-0.016458634,-0.022427162,-0.02895527,-0.063094795,-0.019399807,-0.09545551,0.031619523,0.025429334,-0.010908967,-0.011613067,-0.01788325,0.06835763,-0.003780626,0.004052188,-0.05898643,-0.088917725,-0.013179438,0.04832607,0.046439044,0.013589058,-0.08624594,-0.02916588,-0.055291433,0.037253298,-0.054841768,-0.053350348,0.10556514,0.0010617318,0.009380821,-0.024400689,0.06905467,0.021216892,0.008320116,0.039245572,0.020030688,-0.016436609,-0.0018051486,-0.10189807,1.9557311e-33,0.08192942,0.01406219,-0.014372155,0.07092531,-0.005029271,0.052912258,-0.033584166,0.059287637,-0.07755554,-0.032690436,-0.0882886,-0.06353821,0.07235063,-0.03499123,-0.023558874,-0.013479837,-0.061459266,-0.023697533,0.06136665,-0.052591417,-0.008197781,-0.013545619,-0.03787587,-0.010686349,-0.0060902596,0.09048804,-0.066378035,-0.046922553,0.018820306,0.031283706,-0.014609779,-0.06471239,-0.025879703,-0.0024449273,-0.010024803,0.06619303,-0.035880204,-0.058338106,-0.04638184,-0.014420265,-0.03664319,-0.031952392,0.020512993,-0.035961032,0.027784592,0.016907241,-0.1217329,-0.003427244,0.058340866,0.073692515,0.08614776,-0.12488268,0.108599946,-0.005452863,-0.1297131,0.07642506,-0.02200317,0.009785886,-0.012471753,0.07901475,0.11764505,0.06743516,-0.08430913,0.08945568,0.018442208,0.06483993,-0.06313926,-0.079969324,-0.039010335,0.12867863,-0.08161232,-0.03437451,0.11867466,0.0065418794,0.01805886,-0.0031322776,0.029817697,0.042486504,0.031300902,0.033308603,0.030290393,-0.06271908,-0.016577512,-0.0045871036,0.010374398,-0.047631722,-0.033331394,-0.021425815,0.026411148,0.043228123,0.10007255,-0.11028306,-0.036644243,0.022099767,-0.03333886,-2.2298557e-33,0.10214446,-0.016434094,0.044523016,-0.013526912,0.00086479215,0.09443513,0.038733494,-0.072683066,-0.021742765,0.009189923,0.09259413,-0.03139067,-0.03484279,0.014651506,-0.017989457,0.0011131574,0.0015585561,-0.03849679,0.03281511,0.059638098,-0.07639434,0.0034754744,0.030683491,-0.05642321,0.026330778,0.034912433,0.037399292,0.0037151838,0.057058476,-0.010750181,-0.1318375,-0.012578118,-0.06237145,-0.090596445,-0.0029603895,0.0690762,0.039680026,0.00042793137,0.0025645227,0.049628492,-0.06782123,0.0029116496,0.07296904,0.08459914,0.03421204,0.09976418,-0.044520058,-0.042374104,-0.042180315,-0.04674619,0.058872193,0.018469043,-0.085718766,0.057206433,-0.0078096497,0.03473375,-0.006826061,0.0020193942,-0.057501145,-0.03376705,-0.0244277,0.0066091833,-0.018462026,0.07443667,0.003557677,0.074083544,-0.00014643963,0.036692422,0.015157852,0.003730678,0.053165313,0.021148043,0.029973142,0.057377487,-0.013739248,0.018395154,-0.059769984,-0.03337269,0.036600858,-0.0011048468,0.046785224,0.007067537,-0.06509984,-0.03786749,-0.008163238,-0.10336011,-0.04515756,0.09932387,0.05254837,-0.095152,-0.012893307,0.074321516,-0.018732442,0.04110667,0.046856493,-2.692991e-08,-0.038461987,-0.09547602,-0.020508537,-0.04136734,0.054423694,-0.038263936,0.09038718,0.017218053,0.050265454,-0.023984797,-0.027647544,0.087335825,-0.02077535,-0.009006054,0.059217438,0.03845399,0.005193705,-0.024346314,0.033281263,0.004674433,-0.09151025,5.9185444e-05,0.0020581156,0.027920205,0.028496046,-0.09796525,-0.009807199,0.02211561,0.038981933,-0.00085157127,0.028042326,0.05523978,-0.013255831,-0.038846705,-0.02248073,0.026859354,-0.08394874,-0.033623338,-0.026778713,0.019798895,0.050027408,0.023539757,-0.043761138,-0.028543005,0.024261162,-0.010055172,0.057782445,-0.0028420526,0.020702593,-0.03875109,-0.033299636,0.012653399,-0.012744027,-0.018122952,-0.08784342,-0.040040966,0.08994503,-0.08169919,-0.0076068332,-0.10716599,0.008333657,0.061377373,0.19641693,0.018378096 +1.16.5.1,"A diheme cytochrome that transfers electrons across a single membrane, such as the outer membrane of the enterocyte, or the tonoplast membrane of the plant cell vacuole. Acts on hexacyanoferrate(III) and other ferric chelates.",384,1.0,-0.057501033,0.0035481078,-0.07279837,0.009726491,-0.020743476,0.016288852,0.075225584,0.07541249,0.032750163,0.021640649,0.03099417,-0.10542839,-0.077132635,0.007904233,-0.025136797,0.0036848488,-0.01178304,0.04821947,-0.06199499,0.022058861,-0.0022348969,-0.02672603,-0.0117278015,-0.04136778,0.007512814,0.03424901,-0.10626716,0.04020765,-0.030434743,-0.08373547,-0.019664204,0.10274902,0.045161404,0.05709033,-0.038932268,0.08538227,-0.002481996,-0.059469618,0.0030908377,0.015558569,0.029819626,0.041761845,-0.07049755,0.028261185,-0.06369819,-0.02327499,0.032709245,0.024618708,0.007803272,-0.079517975,0.028587235,-0.0051618232,-0.05231121,0.10096251,-0.07401364,0.05693631,0.06344755,-0.0013192924,-0.0010228901,-0.019617429,0.028503906,0.05103608,-0.015111178,0.0537123,0.04948824,-0.09483398,-0.032035235,0.020284675,0.060933877,-0.06280948,0.010120654,-0.05726192,-0.029560829,-0.054829348,-0.0009728371,0.05478699,-0.027636627,0.0029202776,0.054911625,-0.076569565,0.011100148,0.029146412,-0.04838217,0.03091453,0.038605742,0.037134673,-0.030994512,-0.01834418,-0.047996733,-0.010927136,-0.035144046,-0.01028592,0.006871386,-0.004871403,-0.14488356,-0.015010011,0.082642816,-0.0040466487,0.05654702,0.03089048,0.087302685,0.0648117,0.017830193,-0.018901696,-0.024924994,-0.041759197,-0.012425658,0.02125876,-0.03446522,-0.060474362,-0.043990996,-0.056345224,-0.008674423,0.022348728,0.0135949245,0.053291544,0.055512846,-0.023802638,0.03309104,0.037845965,-0.051962096,-0.03546912,-0.07765836,0.0021704491,-0.0053642597,-0.00076614396,-0.04297742,1.3450968e-33,0.040641177,0.002697832,-0.008134931,0.012342131,-0.057309896,0.019908983,-0.0419162,-0.03839688,-0.02968299,0.011269072,-0.12170178,0.043293107,0.01167268,0.04928671,-0.008571562,-0.016389744,-0.13588452,0.0017497985,0.10182633,-0.0012666871,0.025411796,0.037668664,-0.09308244,-0.07301147,0.06237604,0.01474265,-0.094061255,-0.015590566,0.019807514,-0.0011800656,0.052385833,0.00034166712,-0.0372706,0.030143753,-0.007600049,-0.021327013,-0.059973598,-0.056516398,-0.013866902,-0.015792975,-0.07907274,0.014243356,0.014755035,-0.020527136,0.033006195,-0.014836672,-0.10880304,0.045064963,0.06920677,0.0006020924,0.032266445,-0.11302211,0.0700862,-0.07027257,-0.028128646,0.066307686,0.02292212,0.031905666,0.011139697,0.085376106,0.019792082,0.09063737,-0.11540905,0.093556434,0.12642664,0.009864011,-0.07573294,0.0072028395,-0.006862548,0.068848416,-0.14595585,-0.0063649216,0.0680119,-0.0038939563,0.054934535,0.012696833,-0.045204766,-0.043383196,0.0021729541,0.04104914,0.036154855,-0.07796753,0.016690599,-0.08915742,-0.0384787,0.008778411,-0.006781103,-0.062758714,-0.052507266,0.012236343,0.05222687,-0.0058248574,-0.013816437,-0.06717074,0.049367182,-3.9564385e-33,0.015076813,-0.0068952357,0.027494643,0.022497574,0.034584966,0.09072589,-0.053887423,-0.0033953164,0.025689458,0.06669309,0.012321276,0.054529615,0.09789186,-0.027405476,-0.057567343,-0.04547372,-0.0004886162,0.0021304395,-0.016572922,0.061471224,-0.071431436,-0.03315026,-0.017677577,-0.008089221,-0.0081557715,-0.050037462,0.003591769,-0.0688908,0.030203542,0.018157734,-0.027720427,0.022851933,-0.007470476,-0.022934735,0.020589178,-0.049008556,0.031972524,-0.01448158,0.020208761,0.018234253,-0.11081964,-0.003529714,0.09574617,0.024641132,0.022264285,0.065265544,-0.13271789,0.046495162,-0.042215843,0.088483535,-0.027960546,0.04346145,-0.1006705,0.059355997,0.06590727,0.07279135,0.06509949,-0.035112575,0.027509531,-0.001164199,-0.026826572,-0.0901118,-0.0074996613,-0.031197194,0.009968756,0.059299726,-0.025988517,0.023778312,0.030202882,0.02807312,0.11753116,0.012684717,0.00806215,-0.0807209,-0.076344065,-0.054341078,-0.0050672875,-0.060632795,-0.042805113,0.060404234,0.046151236,0.020548137,0.022141665,-0.05464856,0.098528735,-0.10589578,-0.048303183,0.08599267,0.008420628,-0.013581297,0.051469643,-0.03409174,0.004783615,-0.014646094,0.041219372,-3.611383e-08,0.029683731,-0.014087524,0.030180043,-0.043221846,0.024631308,-0.030704685,0.018843422,-0.041641746,0.057484403,0.031277336,0.033614982,0.12648045,-0.0075114137,-0.03381354,0.11660039,0.08165838,0.051855274,-0.038714882,0.014460974,0.03192121,-0.03683206,-0.039447878,-0.07761236,0.036676668,0.09634628,-0.05790829,0.018953077,-0.013396131,0.030153038,0.017621625,0.07518887,0.044716634,0.0047475747,-0.026676267,-0.049555752,0.050133187,-0.0022564845,-0.06253729,-0.049511354,-0.025667595,0.06274595,-0.012359182,-0.06186534,0.014910812,0.01730601,0.039685298,0.03303475,0.045620874,0.0050166277,0.03407637,-0.04413839,-0.007541254,0.0428595,-0.110155985,-0.07933562,0.06164373,0.0144088,-0.021804186,-0.020103514,-0.05721187,0.01443094,0.037880994,0.15156694,-0.02355748 +1.16.98.1,"Contains c-type heme, The enzyme in Acidithiobacillus ferrooxidans is a component of an electron transfer chain from Fe(II), comprising this enzyme, the copper protein rusticyanin, cytochrome c4, and cytochrome c oxidase (EC 1.9.3.1)",384,1.0,-0.05611496,0.0061481977,-0.048380915,0.05058255,0.082935415,0.03230522,-0.03850133,0.067594856,-0.0031423522,-0.13245621,0.0009776087,-0.10182398,0.0334165,-0.009387272,-0.071411334,-0.036833912,-0.061933264,0.029596634,-0.02634559,-0.046799626,-0.036488216,0.045203317,0.00062740734,-0.030802611,-0.048750173,-0.010360996,0.092701264,-0.040327135,-0.07446334,-0.064341344,0.011163436,-0.041894495,0.041619044,0.01140252,0.013609532,0.09360744,-0.025683157,-0.09092225,0.080833614,-0.01185651,0.018968998,0.056155432,0.01917947,-0.017598901,-0.047086723,-0.040288486,0.08732591,-0.045600213,0.018852789,0.021612668,-0.015017435,-0.038499862,-0.06917962,0.08523173,0.046278957,-0.017106198,0.032755606,-0.059311796,0.01942601,-0.004536005,0.039708823,0.007918115,0.02023594,0.02594948,0.006634632,-0.03243383,0.07344159,-0.037069626,-0.04768287,-0.1068878,-0.06916074,-0.006424112,-0.04447814,-0.029629331,-0.025850162,0.045885544,0.00858798,-0.04603571,0.047169544,-0.028821291,-0.05492599,-0.0406984,0.0020684002,0.14058837,0.031124147,-0.0024035594,-0.007576422,-0.0055264626,-0.08429994,0.04778027,0.037761834,0.026653351,-0.014510057,-0.07082144,-0.06306528,-0.034004156,0.05885655,0.08092229,0.011913664,0.015928496,-0.0056522926,0.094414495,0.025325455,-0.10696796,-0.07457734,-0.0022153512,-0.0016821155,0.09570102,0.08023189,-0.014623617,0.0043127886,0.016507,0.005316246,-0.028828071,-0.01339695,0.037220433,0.032934215,-0.02892332,-0.028703542,0.052902665,0.033557016,0.012525673,0.042003077,-0.012521544,0.0031854128,-0.066260085,-0.08944397,2.2305503e-33,0.023789214,0.027045641,0.022871094,-0.03008672,0.006895488,0.0023999875,-0.06845988,0.021533113,0.011331641,-0.024213515,-0.13945359,-0.061909404,0.023248501,-0.03679278,-0.023447303,0.021373995,-0.056592494,-0.04827687,0.03997538,0.023263765,0.069070615,0.008618476,0.014494094,-0.0037499063,0.050027918,0.021558689,-0.011208039,0.017374184,-0.01430982,-0.004219743,0.038995825,-0.0460098,-0.055869397,-0.0052863103,0.078398794,-0.0148267215,0.0077565406,0.015487639,-0.014492002,0.0073776264,-0.01982744,0.013572418,-0.0023441312,-0.062703595,0.056545533,-0.082418226,-0.08238359,0.12130416,0.0073283636,0.12210683,0.03639277,-0.07245873,0.105996385,-0.036301102,-0.006478352,-0.014475023,-0.048659068,0.047447883,0.030041112,0.07862945,0.16006027,0.08664714,-0.051075116,0.027120756,0.027143834,0.06552474,-0.04643318,0.0073010786,0.023638451,0.004760615,-0.05624748,0.034756787,0.03802178,0.03269911,0.015280049,-0.051938344,-0.14348431,-0.06844151,0.089365415,0.004701869,-0.020520933,-0.044690713,0.04856423,-0.07875157,-0.04434905,-0.0017579284,-0.04518387,0.0058233025,-0.037383325,0.025765233,0.05379463,-0.084820606,-0.07935467,-0.022752773,0.011914441,-2.8730423e-33,0.08044929,-0.035988223,0.04836746,-0.117779195,-0.008853499,0.0155041125,0.049066782,-0.00886491,0.030042587,0.028271243,0.11197197,0.012763231,0.0016562229,-0.04713639,0.0454135,0.047656357,-0.05432103,0.055777133,0.05153736,0.015852427,-0.03132515,-0.0028199488,-0.0027888683,-0.00010559761,0.06529309,0.014349349,-0.072867565,0.06068287,0.09891333,0.05423892,-0.025805434,0.045238048,0.008971795,-0.019676073,-0.073786095,0.015979009,0.0076995324,-0.007370832,0.094743006,0.027296955,0.024674663,-0.024223208,0.0124369925,0.117174536,0.03203542,0.06828534,-0.12037896,0.017306225,-0.012553582,0.016684571,0.00594971,0.041956022,-0.03508186,-0.014233081,0.011953766,0.085753314,0.017529149,0.040833104,-0.023023618,-0.06309832,-0.074878074,-0.032364987,0.0060054595,0.076425344,0.024117975,0.048332196,-0.039853975,0.08477288,0.04957817,-0.038887795,0.059830967,0.016457465,0.017672155,-0.06528323,-0.027672382,-0.06823387,0.005470636,0.04528955,0.030755062,0.03608063,0.0119671,0.052863944,0.0032036472,-0.06130129,0.029369906,-0.0576697,-0.014921008,0.045034654,0.0030922166,-0.10814025,-0.06728473,0.011378491,-0.009079375,0.015229278,0.0142683545,-3.4574512e-08,-0.001348431,-0.107074216,0.020677935,-0.041802935,0.03944687,0.02278379,0.00013763449,-0.014883182,-0.028663559,-0.0150976665,0.020940756,0.14672714,-0.049733724,-0.055710394,0.008128864,0.018772887,-0.026365342,0.029151905,0.018887885,0.005926868,-0.04654832,-0.0077700773,-0.09172243,0.069925115,0.027642732,-0.07488378,-0.007038261,-0.03769749,-0.01776324,-0.00043599948,0.00434488,0.018142855,-0.0072902897,-0.05636555,-0.06587364,-0.008899071,-0.019146398,-0.005352225,-0.018278258,-0.0037204728,-0.0034108718,-0.02220712,-0.1046147,-0.060456987,0.049742088,0.011106123,-0.013016105,0.08094519,0.013269453,-0.009137002,0.02395159,-0.032651056,0.002526951,-0.028446162,-0.064514965,0.07814688,0.071174,-0.07151076,-0.013254324,-0.03426405,0.03893036,0.021076068,0.20867573,-0.03888526 +2.1.1.207,"The enzyme from Escherichia coli catalyses the 2'-O-methylation of cytidine or 5-carboxymethylaminomethyluridine at the wobble position at nucleotide 34 in tRNALeuCmAA and tRNALeucmnm5UmAA. The enzyme is selective for the two tRNALeu isoacceptors and only methylates these when they present the correct anticodon loop sequence and modification pattern. Specifically, YibK requires a pyrimidine nucleoside at position 34, it has a clear preference for an adenosine at position 35, and it fails to methylate without prior addition of the N6-(isopentenyl)-2-methylthioadenosine modification at position 37. ",384,1.0,-0.036162075,-0.035588104,-0.09732249,-0.08339023,-0.030009877,-0.020572867,-0.062922,0.06725864,0.0568131,0.021966863,0.058624364,0.015567055,-0.09393541,0.031251203,-0.017357627,0.08319948,-0.083140835,0.014652462,0.08250001,-0.058873534,0.006553611,0.0033853368,0.016062073,-0.023814049,-0.055285443,0.051551893,0.02644375,0.03574233,0.003269403,-0.0409137,-0.07002344,-0.04746676,0.058843352,-0.06920821,0.10170231,0.084472135,-0.080797724,-0.048314724,0.096619494,0.0018588471,0.017371908,0.0060585192,-0.02331055,0.012307116,-0.06772808,-0.029486872,0.00053857215,0.04533706,-0.03527649,0.028541382,-0.021519784,-0.04211651,-0.045346,0.0343232,-0.0044478476,0.050608683,-0.07562632,0.0037345798,0.006788272,0.08205368,0.077065624,0.048080802,0.014815061,-0.035244264,0.034272484,-0.05883577,0.048001632,-0.01337614,0.03462523,0.00280929,-0.044290055,-0.015494231,-0.026822919,0.049605835,-0.01923867,-0.034898937,-0.0024728056,-0.0026445112,0.045996267,-0.0021700019,-0.05677875,-0.020771842,0.051826127,-0.000719097,0.047863487,0.014178117,-0.1010309,0.05783051,0.068937115,0.06893085,0.101454414,0.0035102707,-0.009819406,-0.047570594,0.018835444,0.017484346,-0.014759537,0.06188192,-0.044487454,0.007004423,0.02481446,0.0063754646,-0.1229806,0.006055221,0.018306635,-0.02197083,0.018693965,-0.047111914,-0.0385957,0.0068489173,-0.0614442,0.08034901,0.0304365,-0.026707623,-0.055434104,0.071585685,0.018125646,0.010086001,0.012777066,-0.041080188,0.01911783,-0.065106355,0.04507898,0.06972708,-0.03452145,0.006313344,-0.103518635,6.854649e-33,0.04246201,0.038040992,0.049843762,-0.0151099125,0.0022693397,-0.02497909,0.02669035,0.025708491,-0.053859282,-0.034160785,-0.07273216,-0.15348297,0.05229467,-0.008667321,-0.0015900265,-0.03469683,-0.07393379,0.051280092,-0.019288357,-0.017688889,0.05449892,0.03899818,0.030958219,0.033898648,-0.039514787,0.08566481,-0.08342317,0.023185309,0.10111394,0.019278163,-0.044074446,-0.046915483,-0.08603386,0.0026020603,0.097608306,-0.0013616561,-0.08372719,-0.0024546145,-0.009096861,0.08913256,-0.017818969,0.001878436,-0.012786987,-0.0018444303,0.006781764,0.02148027,-0.041774366,0.0643585,0.008907554,0.041743435,-0.0024178233,-0.014708094,-0.021524917,-0.02683388,-0.03816305,0.009523581,0.021082694,-0.0433727,-0.027132958,0.05634154,0.0033726655,-0.028079933,0.020230815,-0.01932134,-0.046188638,0.025015779,-0.08441958,-0.07927133,0.0015565199,0.13071603,0.011977202,-0.016107965,0.05066629,0.001426077,0.051232155,-0.0327548,-0.06142745,-0.014898229,0.01549635,-0.017238168,0.021546395,0.05299203,0.014484689,-0.06405303,-0.061353482,-0.05418662,0.0052407687,-0.031109609,0.047151014,0.08658847,0.015353931,-0.076832786,-0.048350662,0.015534119,-0.013251531,-7.341358e-33,0.08371432,-0.08979865,0.08891332,-0.08506045,-0.11202121,0.05557629,0.011977247,-0.08082131,-0.017140832,-0.07152759,0.10518302,0.046996627,-0.07743928,0.07663163,-0.026632357,0.021017281,-0.02130407,0.0593945,0.0055177924,-0.008610349,0.021456748,-0.008028187,-0.011918625,0.08591319,0.02446391,2.8463091e-05,0.02101494,0.003379517,0.08314146,-0.01824687,-0.07296936,-0.04077296,-0.04157613,-0.024781302,0.018568326,0.11575167,-0.057380974,-0.0020943775,-0.052282643,0.02984309,0.013925186,0.007138757,-0.045683134,0.060765117,-0.059367772,0.03825951,-0.09268527,-0.02772122,0.003036025,-0.06713298,0.089474164,0.012723812,0.012694608,0.035813708,0.028804712,0.044747457,-0.048521284,-0.0015005247,-0.013643677,-0.029719183,-0.026942383,-0.057157494,-0.010702644,-0.05926422,0.09667036,-0.0064796354,0.0054555708,0.09935432,-0.0010039142,-0.052265335,-0.025382841,0.0087578045,0.017730735,0.0079556815,-0.039185807,-0.09071052,-0.031225951,-0.086608574,-0.0015720252,-0.06686955,-0.04187268,-0.0028760075,-0.040534735,-0.025132155,-0.032742474,0.025627121,0.07298783,0.0959241,-0.005539292,0.0531493,0.03098644,0.010174075,0.025438387,0.10755801,0.055497196,-5.1971853e-08,0.00809662,-0.13052839,-0.04997015,-0.04487271,-0.018780064,0.06673736,-0.076198064,0.009122899,0.031772267,-0.012086501,0.03984779,0.12870309,0.0370166,0.07506549,-0.017909538,-0.0035841423,-0.09297838,-0.01874943,0.031817406,-0.011996172,-0.08321893,0.07020548,-0.09209786,-0.09386193,0.051999025,-0.041329987,-0.004432019,0.1391113,-0.024415124,0.0059884684,0.03086049,0.0021232916,0.02536744,0.02612539,0.0010478869,0.042431086,-0.025916493,-0.038175244,-0.06497327,-0.0152573595,0.033730857,0.028179552,-0.077191785,0.06365813,0.03459272,-0.023282496,-0.023565881,0.03255732,-0.007855953,0.051419165,0.008284534,0.058083925,0.02726088,-0.016996542,-0.016766448,-0.009300377,-0.0628703,-0.043187223,-0.06511813,0.022906275,0.042134155,-0.06559622,0.17141826,-0.008591229 +2.3.1.196,The enzyme is involved in volatile benzenoid and benzoic acid biosynthesis. The enzyme from Petunia hybrida also catalyses the formation of 2-phenylethyl benzoate from benzoyl-CoA and 2-phenylethanol. The apparent catalytic efficiency of the enzyme from Petunia hybrida with benzoyl-CoA is almost 6-fold higher than with acetyl-CoA [1]. ,384,0.99999994,-0.063037306,0.00975845,-0.09051416,-0.027582968,0.02644271,0.055936802,-0.14534372,0.02167654,0.087187245,-0.08483485,0.043444585,-0.017009517,-0.06317098,-0.0075731417,-0.040700506,-0.0095097665,-0.025354628,0.05603868,-0.09082492,-0.067200124,-0.04734672,-0.08203448,0.029633138,-0.00037556738,0.0128311645,-0.04402556,0.033439737,-0.039752442,0.026520122,-0.041560866,0.04993478,-0.042127296,-0.035690002,-0.054681916,0.026175523,0.010404258,0.008516351,-0.052016586,0.06347907,0.052499443,0.0024035915,-0.057598006,-0.10227302,-0.076650605,-0.09674151,-0.052533835,-0.031206664,-0.04243758,0.051439058,-0.059572536,-0.051860854,0.055629987,-0.056478634,-0.039090566,-0.08714918,-0.0073584467,-0.042153146,-0.03317921,-0.012684535,0.058798302,0.036626745,0.015876861,-0.011351499,0.053994264,-0.0066859857,-0.0659352,0.0022525443,-0.020038001,0.06754696,-0.07244723,-0.031192767,-0.06375504,-0.025105156,-0.026619282,0.0050238194,-0.008909822,-0.034934167,0.03304009,0.051338404,-0.05048436,0.026377186,-0.011695759,-0.06662539,0.05908834,0.077961825,0.030945351,-0.047107663,0.023609368,0.10244609,0.038042672,0.016289212,0.09177336,-9.991017e-05,-0.016616264,0.0037447237,0.057850607,0.04632211,0.02071737,0.021263398,0.028275026,0.010748028,0.09843384,-0.00094633864,-0.1026646,-0.07513663,-0.050967377,-0.010063274,0.06163612,0.052167438,0.020333696,-0.0083550345,0.014629544,0.017872326,-0.025931938,-0.028575849,0.09133247,-0.007630148,-0.10929329,0.007169021,0.050579436,0.01044529,-0.08861014,0.022504637,0.06207755,0.08385871,0.0145747755,-0.07699593,3.240083e-33,0.09801659,0.05291146,0.007129859,-0.040144674,0.0018135837,0.0045688725,-0.10727875,0.0468668,-0.081956156,-0.01656654,-0.0742423,0.016026866,-0.005563907,-0.031343203,0.059169047,-0.023845067,0.014565941,0.012500836,0.04255237,-0.043932363,0.0423595,0.022495268,-0.019047951,0.06907978,0.021727057,0.011316437,-0.07076222,0.054718178,-0.04736944,0.030228505,-0.029512398,-0.10985635,-0.069630645,0.0038598073,-0.025468871,-0.0028085224,-0.120895,-0.060036276,0.011677856,0.069649704,0.095033206,0.015205084,0.09524859,0.008398763,-0.04679152,-0.003698901,-0.09294092,0.09255171,0.07816765,0.031938918,0.053899243,-0.0010544942,0.0689826,0.021217823,-0.066293,0.050740477,-0.009984688,-0.055333633,0.024433363,0.014228661,-0.058126885,0.09129394,-0.022809355,0.0414916,-0.02130307,-0.071540445,-0.08371058,0.06798139,-0.022025343,0.08360291,-0.02016779,-0.04943765,0.01022895,0.024731217,0.067243695,-0.08442879,0.031233339,-0.003534959,0.0986734,0.02983298,-0.009749124,0.0922375,0.0054389643,-0.025109006,-0.036663968,0.003931005,0.0012091806,0.006083118,-0.048893154,0.040504057,0.073211655,-0.043774515,0.06993427,-0.01797951,0.03811999,-5.4797954e-33,0.06296982,-0.049980752,0.0727058,-0.116469204,-0.029571734,0.010333442,-0.0064431266,-0.00018109416,-0.052460633,0.051403176,0.04034111,-0.02515123,0.066214964,0.038023427,-0.019638624,0.04106258,0.077025436,-0.006437282,0.059088547,-0.041200127,-0.030488236,0.02308538,0.05217219,-0.018597303,-0.0023037384,-0.02401918,0.013790295,-0.007319948,0.0007379393,0.02294075,0.035641134,0.021361379,-0.06802167,0.050764494,-0.0010102824,0.067801684,-0.05048973,-0.04365357,-0.012295579,0.016304946,-0.07951166,-0.055789303,-0.044193797,0.015900481,0.036147494,0.030833844,-0.011582508,-0.079370275,-0.054287635,-0.07604431,0.087318696,0.072872266,0.011449375,0.026643272,0.006576716,0.088732965,0.0631251,-0.056398366,-0.04351068,-0.06630332,0.051864266,-0.04880444,-0.03229708,0.06536248,-0.0102454405,0.03965918,-0.028785063,0.019623265,0.0038844652,-0.009355226,0.06206574,0.06252967,0.03214764,0.08815058,-0.07079616,0.0068312827,0.01928987,-0.043661583,-0.031933352,-0.07174886,-0.06087763,-0.02434853,-0.0043873927,-0.11476813,-0.11923782,-0.075776115,-0.024830809,0.071801744,0.019438215,0.040722262,0.01950123,-0.0042434293,0.035346154,0.06797862,0.05487041,-3.42401e-08,-0.056265995,-0.08210706,0.015657088,-0.03579245,0.018117676,0.0071139154,-0.022864064,-0.07599453,0.02285122,-0.03807059,-0.03655919,-0.003250611,0.014086453,0.020657104,0.039399542,0.07116237,0.017077234,0.0051151286,0.0022931725,0.030504605,-0.010147331,0.095946886,-0.07419991,-0.01802364,0.019394752,0.025991278,0.059300885,0.06371316,-0.06694997,-0.017782789,-0.0073958416,0.0066454494,-0.029698735,-0.009974679,-0.04428503,-0.0023624513,0.08142728,-0.031405233,-0.07333083,-0.033704776,0.07536566,-0.043518208,-0.12769492,0.03688638,0.06752122,-0.000784071,-0.027952245,0.011733515,0.03542646,0.018377494,0.027722504,0.031266388,0.016985547,-0.04720923,-0.034555145,-0.035371713,-0.021960026,-0.030605309,0.0013788901,-0.06764184,0.07308812,0.047476176,0.1351123,0.006410623 +2.4.1.262,"Requires a divalent ion, Mg2+ better than Mn2+, better than Ca2+. Also acts on soysapogenol A and E.",384,1.0,-0.064540036,-0.103455536,0.023025801,0.020120095,0.027927266,-0.004407575,-0.039498236,0.09311616,0.031327926,0.049864735,0.08148222,-0.041136187,0.03673898,0.030892443,0.020811947,-0.05359022,0.0223947,0.04454732,0.0037335444,-0.021643184,0.11546343,-0.032090694,0.011152011,-0.039543286,0.03203428,0.037908755,-0.0020360094,-0.01743307,0.06929637,-0.039068814,-0.009142647,0.050599795,0.08035212,-0.11669127,-0.019042954,0.12191802,-0.06878903,-0.041550122,-0.040186305,-0.09318721,0.034604616,-0.006939652,0.13907006,-0.05066102,0.028477456,-0.10103136,0.053735107,-0.08691113,0.040666714,-0.003959181,-0.053224534,-0.031391483,-0.027572162,0.010562663,-0.014368056,0.0047542485,-0.08266178,0.04859133,-0.0062642917,-0.00030313118,-0.054851186,-0.037150357,0.0034729927,-0.025510373,0.058308203,0.016416468,0.004985999,-0.029604124,-0.015372229,0.048998874,-0.008305607,-0.02202134,0.014586427,0.056525867,0.019189173,0.035780624,0.03510481,-0.057590883,0.07944738,0.012175919,-0.021075016,-0.031626254,0.011745718,0.0504928,0.047150202,0.07267411,0.04494051,-0.032292206,0.014275458,0.04361918,0.043624055,0.106393285,0.06020949,0.04291186,0.008229859,0.044247523,-0.051023357,0.02535592,-0.03497645,-0.014038063,0.046174135,0.07340048,-0.14006694,-0.027844751,-0.026806662,0.0011131088,0.018949589,-0.0026015788,-0.03568612,0.0821206,0.087515056,0.021124132,-0.011402234,0.007453943,-0.053521592,0.08199325,0.067609884,-0.07616673,-0.015779214,-0.050703757,0.021519031,-0.0373559,-0.047932714,0.011014979,-0.051412407,-0.0254004,0.025511473,3.2765887e-33,0.008406515,0.018876744,-0.011803554,-0.018149069,0.013014403,0.04672979,-0.09723192,-0.055349372,0.022244662,-0.11850109,-0.08250141,-0.061716795,-0.021438537,0.09683242,-0.00992184,-0.04721628,-0.03748861,-0.035168365,0.10737928,-0.0077622263,0.044347137,-0.021124562,0.020847484,0.01014479,0.0056790137,0.060476866,0.08153955,-0.018975155,-0.022557806,-0.008817534,0.0213599,-0.07766168,-0.06362057,0.07127981,0.03944873,0.058553915,-0.04081022,0.024950331,-0.02456863,0.02503407,-0.040848304,0.08706926,-0.027311228,0.07665839,0.069190495,-0.104327366,-0.024650645,0.019552028,0.030335933,0.09491516,0.025125911,0.027619546,-0.011336749,0.008278643,-0.034976922,0.023907311,0.019356562,0.019816535,-0.05945,0.03408708,-0.04268084,0.04383677,0.07004655,0.03435883,0.020760493,0.04053654,-0.10215578,-0.07611561,-0.008867616,-0.0063725514,0.028225925,-0.09650071,0.09864754,0.034862667,-0.015400104,-0.00789155,-0.074783474,0.028806826,0.021635031,0.017764417,-0.009517146,-0.0450923,0.01985534,0.033466548,-0.10132508,0.0010717108,-0.02600928,-0.028806735,0.02260879,0.015897257,0.08782277,-0.02552451,0.026749752,0.016804684,-0.027027471,-4.1450517e-33,0.0036083884,0.024137154,0.058269694,0.03005996,-0.085849956,-0.021709567,0.011795963,-0.12591791,0.078601725,-0.009405086,0.04776161,0.01349096,-0.021374717,-0.033045154,-0.030071732,0.03219252,0.028544802,0.06504063,-0.017728591,-0.013450673,-0.011765666,0.14118905,0.03860403,0.11458248,0.07786446,0.040795017,0.015179318,-0.017544266,-0.03370371,0.008752804,-0.023792494,-0.020069283,-0.065160386,-0.048282757,-0.038062472,-0.002979194,0.004832203,-0.05734257,-0.044969548,0.04538085,0.0012680548,0.019553892,0.011373839,0.022601787,-0.04399577,-0.018130252,-0.0075628418,0.045686346,-0.006454113,0.0036094761,-0.0035815367,-0.012899118,-0.058896672,-0.048432715,0.023060052,-0.032150496,0.052338988,0.030528842,-0.0011192854,0.004220541,0.02765629,-0.039776582,0.008719043,-0.12071481,0.037123684,0.044103213,-0.012520324,0.033157468,0.07289652,-0.015486656,0.069372654,0.04707279,0.08354285,-0.039799377,-0.036483347,-0.024235582,-0.01812721,-0.046357576,0.039977618,-0.1083389,-0.009754799,0.056309223,-0.0013402523,-0.0551049,0.010689539,-0.028626028,-0.042412885,0.044879623,0.0011005873,0.08610603,-0.025250053,-0.04952933,-0.023318164,0.044907447,0.0747104,-3.253202e-08,-0.005797207,-0.038563475,-0.06502654,-0.07407739,-0.028669298,0.03211482,-0.062530115,-0.056491986,0.08575552,-0.012838267,-0.0017090582,0.063541606,-0.026706263,0.07978942,0.021395195,-0.043136835,-0.00477138,0.08033973,-0.1003814,-0.063458644,-0.115606815,-0.038307473,-0.17724928,0.026744278,0.027681608,-0.037611943,-0.010939299,0.06217261,0.04453249,-0.015125617,-0.0108569795,-0.007205172,-0.027978757,-0.085659154,-0.01928139,0.07176026,0.018871676,-0.036098268,-0.04595186,-0.0331175,-0.06871253,-0.01908056,0.010871294,0.046295904,-0.0546102,-0.016109446,-0.021240322,0.040743906,-0.034527507,0.050191604,0.05845635,-0.114549406,-0.010588041,-0.1198776,-0.09789523,-0.020482857,0.0064317067,-0.017371189,0.032494213,-0.08181147,0.055303626,-0.027368153,0.054542214,-0.05533714 +2.4.1.263,"The enzyme acts better on (S)-2-trans-abscisate than the natural (S)-2-cis isomer, abscisate, or its enantiomer, the (R)-2-cis isomer.",384,1.0,-0.03083331,-0.11866951,-0.068874985,-0.003530957,0.07066588,-0.018761966,-0.09550704,0.11869485,0.015938459,-0.022862017,0.076202296,-0.03042776,-0.033943493,0.020048415,0.022631265,0.011622963,0.018107025,0.022518264,0.002448881,-0.07649997,0.052944075,-0.04833909,0.00113402,0.060121838,0.041621797,-0.012403361,-0.024752282,0.033426784,0.056785952,-0.07690896,-0.035207797,-0.06379657,0.018214678,-0.061988804,0.011097116,-0.010536121,-0.035803396,0.033893663,0.062332626,-0.04065469,0.049404632,-0.026584964,-0.0022740692,-0.008895178,-0.044876453,-0.060862295,-0.030456085,-0.01692134,0.009305872,-0.002431362,-0.029253524,-0.034895077,-0.05267722,0.039961044,-0.059068415,0.07210979,-0.08412315,0.0069660204,-0.07901811,-0.0055219745,0.07898728,-0.041382454,-0.0034385337,0.020428209,0.036364347,-0.026502142,0.047085937,-0.03418097,-0.0018420964,0.010700259,-0.02669083,-0.048039548,-0.13298279,0.048048094,0.037057105,-0.05616771,-0.033858955,-0.0071901525,-0.01797293,0.0026536232,0.075300895,-0.005480805,0.021689719,0.002832795,0.0406556,-0.002317446,0.045085736,-0.0023941777,0.0018586526,0.056810137,0.12687881,0.042992324,0.03900588,-0.043231424,-0.014051819,0.032129258,-0.053221703,0.09616512,0.009021163,-0.041089483,0.021173399,0.046771828,-0.12597328,-0.098535515,-0.02950292,0.010535254,-0.05312214,-0.004044036,0.0159025,0.017649803,0.014029737,-0.017817305,0.08803363,0.02988732,-0.034014974,0.09204304,0.054211766,0.017373953,0.060372546,-0.009809815,-0.024139887,0.022763044,0.0231713,0.0590263,-0.012684156,0.058769047,-0.061404917,-2.7026004e-33,-0.0038562373,0.047849715,0.0028195784,-0.01411573,-0.018542191,0.027069675,-0.093623616,0.0514557,-0.08046621,0.018655542,-0.078233086,-0.07337176,0.02736148,0.0039206366,0.02985783,-0.004404458,0.051588226,0.013955943,-0.029604558,-0.018598618,0.040101565,0.07592263,-0.07134418,0.027433105,-0.013775635,0.040732726,0.0086137485,0.052804656,-0.03220296,-0.027369427,0.03299128,-0.053257186,-0.0554403,0.073251165,0.08715152,-0.008405263,0.06341483,-0.0048197065,-0.025099274,-0.014225775,0.00741969,0.054177817,0.0044227755,-0.031043014,0.15182987,-0.057788316,-0.050594673,0.060118206,0.082118265,0.05936017,0.025400734,0.007432543,0.052863162,-0.01734088,0.0013302522,0.025249211,0.011002515,0.06834398,0.018056365,0.00072766026,-0.08887,0.03900034,0.038598698,-0.01740394,0.03435248,0.06570518,-0.10755909,-0.08093984,-0.036588684,0.10659939,-0.089997806,-0.0060223113,0.023649046,0.028746596,0.0980213,-0.06530264,-0.115603864,-0.007823801,0.02256336,0.010934083,-0.13400169,0.07053588,0.010076575,-0.006471579,-0.034556787,-0.10496841,-0.035815194,0.024257783,0.052639283,0.066795304,0.09299438,-0.0029548255,-0.10177237,0.10911485,0.034250878,4.4565787e-34,0.042458955,-0.10946192,0.0355877,0.015478293,-0.085519396,0.07848042,-0.006704993,-0.049786165,0.09112584,-0.00033768086,0.1438601,0.025127176,-0.03532346,0.012365178,0.05909877,-0.05392492,-0.0126536265,0.053472884,-0.025400767,-0.005343221,-0.020623285,0.11386571,0.014863533,0.063177,0.0030454542,0.032962296,0.012963429,0.13059847,0.057376202,0.028888946,0.011333429,-0.036962908,-0.039157923,-0.019400097,-0.065881774,0.06804747,-0.04938582,0.026576152,-0.06553208,0.04343576,-0.058227994,0.055607107,-0.03639929,0.057014808,0.018838424,-0.023510303,-0.031243563,-0.034774385,-0.034567527,-0.08530353,0.0075589,-0.056580715,-7.0987116e-06,0.021448476,0.024652421,-0.042808384,-0.09182314,-0.0026194935,-0.06074715,0.008239552,-0.006145507,-0.016009327,-0.034463834,-0.048463397,-0.011625208,0.02382891,-0.031493545,0.027494965,0.04156337,-0.06690119,0.046498436,-0.0072397566,0.0030398527,0.02387436,-0.022240184,-0.022874985,-0.006069923,-0.0797647,-0.00883201,-0.070483744,-0.1099559,-0.0035889545,-0.030467384,-0.05421911,-0.071491085,-0.016503153,-0.036189776,0.042500433,0.02209287,0.019661808,-0.019842613,-0.002934691,-0.022399997,0.02499553,0.11317447,-3.5169656e-08,0.061571352,-0.054439772,0.025713893,-0.02945042,0.0020746444,0.021008031,-0.054627284,-0.05261044,-0.025497356,-0.034080435,-0.08524033,0.043078,-0.0035004953,0.02718209,0.08878401,0.011036556,0.042657353,0.066461705,-0.01688884,0.024532156,-0.08883277,-0.03438498,-0.09170244,-0.055124577,-0.001507751,-0.021460885,0.034722973,0.05262324,0.0053502326,0.047297247,0.07412963,-0.0236008,0.08355891,0.070468985,-0.063428976,0.0061149676,-0.017918319,-0.019736003,-0.034698714,0.017264197,0.06409434,-0.049217302,-0.10421443,0.028889274,-0.036625706,-0.03784874,0.054043267,-0.0058951173,-0.0138397105,-0.011724026,0.029449452,-0.07212863,-0.040426914,-0.04324303,0.008536557,-0.008927208,-0.005006292,-0.0099841505,-0.034056753,-0.0021315922,0.041254688,0.014589503,0.13335605,-0.04478604 +2.7.1.170,"This enzyme, along with EC 4.2.1.126, N-acetylmuramic acid 6-phosphate etherase, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling. The product N-acetylmuramate 6-phosphate is produced as a 7:1 mixture of the alpha- and beta-anomers. 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+3.1.1.86,The degradation of rhamnogalacturonan by rhamnogalacturonases depends on the removal of the acetyl esters from the substrate [1]. ,384,1.0,-0.015716339,-0.111102395,-0.026049035,0.00471506,0.05434288,0.044663314,-0.04736749,-0.011585614,0.03530004,-0.039773084,0.012016654,0.08658301,-0.0398584,0.006592211,-0.066569045,0.093430385,-0.028902516,0.006860515,-0.029710213,-0.002221849,0.093675666,-0.035955857,-0.04381714,0.007691677,0.06925511,-0.00080309133,0.01894291,-0.021222975,-0.069481716,-0.040756356,0.06562147,-0.032587208,0.034453414,-0.047885474,0.030043028,0.09716339,-0.096692935,-0.10285342,0.114557125,0.008719082,0.07382961,0.0027719806,-0.027431738,-0.031446245,0.029075181,-0.024839193,-0.106828354,-0.00040457363,-0.0017436093,-0.042935234,-0.026876159,-0.044655234,-0.015188286,-0.0007922592,0.03889885,-0.055522688,-0.08183093,0.00035152395,-0.062738724,0.11721567,0.03986971,0.09625636,-0.015462407,-0.0450778,-0.08617557,-0.02750302,0.013484225,-0.035719186,0.04945669,0.089424126,-0.055046964,-0.03430371,-0.04846441,-0.09241002,0.0051041283,-0.085043505,0.0017916535,-0.08593649,-0.023221428,-0.00031318088,0.01816703,0.0013503338,-0.008600189,-0.02097357,0.012750912,0.011578858,0.012121737,-0.024299897,0.013079795,0.057027947,0.03131187,-0.010403802,-0.008376501,-0.042123243,0.003710478,-0.061695848,0.011568105,-0.0017415055,-0.0010571289,-0.016379222,-0.07046838,0.00019958615,-0.029161002,-0.13980734,-0.06689473,0.05107333,0.0035335016,0.042526886,0.049026188,0.02640838,0.00771039,-0.003582884,-0.022133097,0.03337973,-0.05202269,0.08224153,-0.0037039944,-0.046596907,-0.12665482,0.040923852,-0.055618815,-0.007184468,0.05481899,-0.00018255167,-0.028618287,0.013759688,-0.0318808,1.2132564e-33,-0.03990542,-0.03632785,-0.050276656,-0.06494799,0.016569052,0.0026281849,-0.051679462,0.017797722,0.13010699,-0.045511387,-0.020450275,-0.052371822,-0.10380036,0.011344323,-0.024128858,0.02698059,0.040290855,-0.032090597,0.043854535,-0.036772184,-0.099777915,0.050308444,-0.079224855,0.010998492,-0.05532498,0.0061147376,-0.029974043,0.026863746,0.018708842,-0.012440293,0.06289046,0.0038487022,-0.1315311,0.050091337,0.03158774,0.055244632,-0.0063014436,-0.026362438,0.004296723,0.008246596,0.002957354,0.039339527,-0.014556565,-0.032799907,-0.0058615305,-0.022062412,-0.024990005,0.10508501,0.11253808,-0.009893693,-0.0070105046,0.0139629785,0.11829207,-0.021440396,-0.035744905,0.0053428854,-0.026199963,-0.0049151983,0.05998482,0.01630092,-0.052310556,0.0033243513,0.019637942,-0.033926122,-0.00084618735,0.056393046,0.025943317,-0.038979985,-0.011518202,-0.014808518,-0.0067152493,-0.01425532,0.022956362,0.020749146,0.062038574,-0.052027557,-0.018927151,0.04033544,0.046348393,0.039872177,0.03433095,0.021998355,-0.015742596,-0.014962865,0.016763374,0.025063964,0.013970983,-0.024914727,0.12727568,0.11657916,0.010199452,-0.08500499,-0.04096808,0.07998388,0.049552377,-2.8073145e-33,0.0478181,-0.06846784,0.030381868,0.02231728,-0.075268544,0.042743348,0.004033885,0.098554984,-0.022662975,-0.0061540855,0.031309076,0.0024381292,-0.030560609,0.017161906,0.057453547,-0.011324753,-0.022872623,0.1015687,-0.0069975993,-0.01715272,-0.045190822,0.08473221,0.0017337577,0.060976204,0.04082891,0.046575587,-0.07250562,0.07540307,0.04187976,0.0051976936,0.004566727,-0.0417352,-0.05725881,-0.07059747,-0.02772312,0.06308054,0.0025856644,0.06377742,-0.06437667,0.06516158,0.06838086,0.046299543,0.038402636,0.02951096,0.0636855,0.015777726,-0.051782943,-0.034264963,-0.030450601,-0.05378434,0.008783374,0.051096875,-0.042566106,-0.043393943,0.027129715,0.08515216,0.021282382,0.03393459,-0.008646289,-0.05000912,-0.10888089,-0.053440314,0.00981843,0.0030722024,0.028021604,0.04536913,0.05692406,0.09807664,0.09867765,-0.023462119,0.07752146,0.06550407,0.072392434,0.011275989,-0.019279823,-0.04440555,-0.096904114,-0.06255553,-0.003040213,-0.067924306,0.110185035,-0.010068887,-0.043377113,-0.10180392,-0.08443415,-0.003576227,0.06776839,0.024890207,-0.040344033,-0.006189114,0.079677545,-0.039425116,-0.08539566,0.026812864,0.029673891,-2.567608e-08,0.017626703,0.03305325,0.10684743,-0.029147612,0.080213316,-0.0029676843,0.051430684,0.06649799,0.048278756,0.008488662,-0.04071419,0.052129183,-0.03555912,-0.010179831,-0.03709149,-0.053339507,-0.057141144,0.034345463,0.036622334,0.056375485,-0.05721924,0.004407352,-0.061220635,0.0012745595,-0.00624997,-0.09198817,0.056963608,0.07890518,-0.055983182,0.050782677,0.061289072,0.06795217,0.040330227,0.065283045,-0.077479884,-0.052559763,-0.031589106,-0.040039137,-0.03786035,0.0072939834,-0.09628294,0.013628182,-0.026058156,-0.0005257668,-0.017278412,-0.054342773,0.061136317,-0.042756554,-0.000537027,-0.0193087,0.05269073,-0.027231425,-0.012183416,-0.08779897,-0.049855795,-0.06714857,0.02697675,0.022141289,-0.050256703,-0.05619759,-0.009747401,-0.013778404,0.13148531,-0.0119088385 +3.1.3.84,"The enzyme is highly specific for ADP-D-ribose 1''-phosphate. Involved together with EC 3.1.4.37, 2',3'-cyclic-nucleotide 3'-phosphodiesterase, in the breakdown of adenosine diphosphate ribose 1'',2''-cyclic phosphate (Appr>p), a by-product of tRNA splicing.",384,1.0,-0.028325818,-0.053219732,-0.0052128253,-0.10931451,-0.0014066407,-0.063570365,0.015007651,0.02082874,0.02526481,0.06377936,0.048275054,0.04141556,-0.07567118,0.08194806,-0.020166557,0.05097199,-0.09057304,-0.018848032,0.09713539,-0.008629644,0.07469881,0.09037171,-0.035533197,0.0060500624,0.055656876,-0.0027677107,0.07843857,-0.019947242,-0.018853255,-0.025815947,-0.038986295,-0.0688221,0.05197913,-0.019058969,0.04699496,0.12720299,-0.07272051,-0.018659152,0.0043132026,0.08351146,0.08763464,0.010670093,-0.012200628,-0.04238354,-0.06084411,-0.038136456,-0.07738519,0.11418428,0.021809457,0.04658019,-0.0035321345,-0.009413346,-0.023133568,-0.100182004,0.004531282,0.035928883,-0.024763586,0.011847056,-0.037867885,0.029461976,0.02905251,0.012987766,-0.014659835,0.0021490033,0.15218793,-0.06268593,0.111749105,-0.01613469,0.020605234,-0.017548267,-0.032198872,-0.06319318,-0.029348234,0.02270639,-0.010986284,0.011011945,-0.04235686,-0.041416075,0.019628616,-0.0766172,0.06646068,-0.017491087,-0.016675588,0.028859535,0.027528636,0.0072371713,-0.027390517,0.0242525,0.012446756,0.010460938,0.0040867985,-0.04724199,0.008925043,-0.0166167,-0.009949459,0.05541819,-0.017897265,0.052694943,-0.029981773,-0.043623973,-0.0053528086,0.11273948,-0.04420398,-0.069062255,-0.009026082,0.013027116,-0.04138912,0.007762159,-0.0076330667,0.05770503,-0.0048497184,0.044146903,0.059687413,-0.07672932,0.012101801,0.07208985,-0.07642962,-0.07084971,0.08526773,0.04167315,-0.016701326,-0.029530162,-0.021906063,0.1135509,0.017586946,0.08232033,-0.078682914,-4.895056e-34,0.068921894,0.018233502,0.070914924,0.022943674,-0.018466173,0.026953058,-0.09568639,-0.015146323,-0.0838052,-0.0047267396,-0.115444496,-0.13330333,0.09000971,-0.031186523,-0.01494644,-0.03738773,-0.0514671,0.03486741,0.040448315,0.014502076,-0.011519365,0.035347927,-0.055124342,0.08094905,0.021996554,-0.0059906784,-0.07121003,0.040417273,0.086068556,-0.01947128,0.049467403,-0.05991986,-0.1383766,0.0017767544,0.0014001896,-0.07790445,-0.072822675,-0.038508944,-0.017642839,0.08231558,0.0020293384,-0.031335775,0.028632116,0.019666618,0.010969304,-0.03292207,-0.021652378,0.030226896,0.0028662176,0.05284466,0.06591554,-0.03704262,0.087159336,-0.044671692,-0.048985697,-0.027424661,-0.03648705,-0.06227464,0.06751955,0.048533708,0.026437541,0.0417702,-0.045190576,0.037743542,-0.06542397,-0.011281526,-0.011120226,-0.110161185,0.02167725,0.046466246,-0.054799367,-0.035755053,0.09148996,-0.033471808,-0.02767857,-0.0072559314,-0.009225482,-0.017415613,-0.06578173,0.027961884,-0.05103159,-0.050186682,0.05810747,-0.0057377433,-0.014143008,-0.029551929,0.02988731,-0.09686127,-0.019725664,0.026216557,0.065798685,-0.024150219,-0.12652434,0.0126603255,0.032874443,-1.5278863e-33,0.05567999,-0.04921063,0.076130636,-0.09165322,-0.08839174,0.011721726,0.04195826,-0.020797336,0.0336035,-0.07508326,0.06857105,0.0070380806,0.015200867,-0.05150486,0.006506004,0.053059738,-0.022303168,0.03250717,0.006231061,0.051450577,0.06082619,0.06951987,0.02268134,0.08659889,0.035313677,-0.052043762,0.014980551,0.027244603,0.056667794,0.008190825,0.0071014226,0.04967396,-0.022222003,0.05396123,-0.07963028,0.009186455,-0.07366467,0.018687246,0.036193132,0.021808604,-0.05475183,0.097700045,0.01725805,0.038558874,0.025405169,0.07978113,0.04588998,-0.013075719,-0.06614692,-0.0669895,0.004697828,0.023524154,0.07178065,0.039988354,0.020429302,0.0192717,-0.02214043,0.07207372,-0.03576929,0.0026102636,-0.009062403,-0.020743296,0.02280374,-0.020807303,0.06523376,0.027411684,0.008014839,0.006732522,-0.014252499,-0.017388675,-0.026659004,0.026629515,-0.034110215,0.025649156,-0.0077982424,-0.023654869,-0.11523007,0.018962964,0.020601619,-0.053087443,-0.027406381,0.0317535,-0.024807464,-0.004107469,0.003710822,-0.028824138,0.0069604754,0.09207605,0.0024501083,0.04820451,-0.040597618,0.003723169,-0.021194566,0.009076159,0.023528416,-3.9712326e-08,0.061994363,7.4574775e-05,0.0067088217,-0.115887344,0.08970974,0.015419505,0.02092216,0.029183824,0.06778514,-0.010565734,-0.050560802,0.037098415,-0.056519106,-0.0023543986,0.10598031,-0.0032811882,-0.09671762,0.03415689,-0.04923468,-0.034644537,-0.033706915,0.026380919,-0.15715757,0.055286836,-0.015467202,0.03600392,0.06886771,0.03911786,0.06391482,-0.008847951,0.01178766,-0.01406718,0.0050373087,-0.08427509,-0.08261831,0.060052853,-0.007487749,0.008041523,-0.028065953,0.06888197,-0.031571582,-0.09630177,-0.01885993,-0.008205986,-0.053563878,0.022954037,-0.0063593006,0.008686708,0.0041020084,-0.029021287,0.0668157,0.022810705,-0.06827118,-0.07886545,-0.07002697,-0.031463448,-0.06353873,-0.08348586,-0.003306962,-0.03468114,0.0022560381,0.028389545,0.10386403,-0.028950667 +3.2.1.170,The enzyme occurs in thermophilic bacteria and has been characterized in Thermus thermophilus and Rubrobacter radiotolerans. It also has been identified in the moss Selaginella moellendorffii.,384,1.0,-0.0909347,-0.06658201,-0.18880825,0.051722728,-0.0120365145,0.045622334,-0.029452192,0.017661197,-0.0043461523,-0.012825985,-0.0074349167,-0.08502119,-0.002261175,0.0895969,-0.04468747,0.005624847,-0.042484008,-0.0261983,0.039091956,-0.049086183,0.06365945,0.0748972,0.020122558,0.006382749,0.0194912,-0.037918713,0.033266302,0.035941467,-0.050260298,0.016570853,-0.023106132,0.039072126,0.12930405,-0.031123755,0.12531926,0.0571298,-0.04529957,-0.07356879,0.06523053,0.013964097,0.009944913,-0.012198808,-0.014081399,0.034399945,-0.14170751,0.037123684,0.08736362,0.011805074,0.06373096,-0.045811355,-0.037041776,-0.049598314,-0.06268715,0.06178983,0.003252056,-0.0192538,0.042137887,-0.064373136,-0.05246131,-0.0104990145,0.05983626,0.0334407,-0.004065744,0.068862,0.004266453,-0.0080626225,0.016762974,-0.04500363,-0.037311967,-0.057802904,-0.061498363,-0.06029764,-0.036626726,0.04898557,-0.035938818,-0.014698181,0.034444526,-0.0442378,0.03336755,0.009329096,-0.026453087,-0.060060106,0.00824798,0.06871505,-0.033278465,0.040514264,0.08580854,0.031615753,0.07240671,0.033813454,-0.04291137,0.014240186,-0.06307829,-0.09605245,-0.026508719,0.0032941822,0.027736165,0.018065281,0.084863216,-0.091872886,-0.03002353,-0.02687625,-0.028399132,-0.09139645,-0.026869578,-0.036165964,-0.03278582,0.041566856,0.031755652,-0.030936705,0.014777591,0.048286423,0.03282449,-0.031268213,0.043461658,0.029699573,0.058847494,-0.0281516,-0.08004754,0.080919035,-0.02529729,-0.009624568,0.038776133,0.08421646,-0.066007346,0.059279453,-0.11382146,3.4803644e-33,0.028179873,0.031261608,-0.004707798,-0.056025762,7.951542e-05,-0.0016411078,-0.097570695,-0.024046209,-0.07115061,-0.0035454663,-0.014303072,-0.025842482,0.051209867,0.0042029982,-0.002471321,0.03751809,-0.043416623,0.022955442,-0.019745674,0.0131713,0.00425318,0.12972932,0.027677283,0.020111915,0.016007125,0.10801035,0.035595816,-0.012387643,0.064205706,-0.011437374,0.06153064,-0.13976671,-0.1632545,0.033879142,0.12198568,-0.02612544,-0.012360611,0.010337576,-0.03890716,0.0264761,0.06373767,0.023304274,0.049255326,0.03489708,0.07462038,-0.0381299,-0.030430881,0.0884061,0.093274996,0.037266582,-0.031486243,-0.015656369,0.092115924,-0.06937426,-0.040731676,0.027484234,0.022690171,0.05513971,-0.005706906,0.017996512,-2.0551966e-05,0.013950928,-0.038207524,-0.029578159,0.06497789,0.027169561,-0.045254413,-0.05959122,0.020895047,0.06100755,-0.105577275,0.019907951,-0.020004345,0.046196252,0.050812516,-0.055550892,-0.046034284,-0.038076177,-0.052866213,-0.006040539,-0.065225065,-0.052588917,0.06395878,-0.061781723,-0.06473891,-0.038972635,-0.021847581,0.026830982,-0.055610318,0.05893585,0.058665317,-0.03633852,-0.033358987,0.062434748,-0.0026762218,-5.7443885e-33,0.050181553,-0.12511623,0.018024176,-0.06670124,-0.08700243,0.030747516,-0.031071352,0.010037099,-0.05915212,-0.0066579417,0.071361594,0.016942495,0.03203165,-0.05404281,-0.0061570364,0.019484624,0.063512035,0.050136767,0.02188651,-0.04279265,-0.04700573,0.0466926,-0.007580261,-0.0782564,-0.04202256,-0.0035752286,0.030874,0.0516092,0.011283218,0.029788077,0.019116884,0.016471561,-0.04812263,-0.054655362,-0.060912166,0.016369624,0.0006992587,-0.010770726,0.060458537,-0.012754727,0.03672147,-0.018973256,-0.027957726,0.069275334,0.022100367,-0.028189683,-0.113607556,0.048037205,-0.0094486,0.06508541,-0.00332405,-0.05313459,-0.011402983,-0.025275081,-0.01099361,-0.0025940975,-0.04510475,0.014955319,0.007189444,-0.03643132,0.018820876,-0.06186812,0.073690735,0.11293133,0.011712785,0.097947165,-0.06792119,0.0070299217,0.04899814,0.023445895,0.07616474,-0.017480753,-0.07673424,-0.045083154,-0.003863018,0.011559026,0.0169812,0.035943672,0.032561433,-0.0021008055,-0.0043182014,0.07577586,-0.01556564,-0.0076195975,0.033951107,-0.08787397,0.061201718,0.0450163,-0.011771664,-0.031871397,0.025804408,0.00047582958,-0.029953828,-0.0058820904,0.044375133,-3.4050228e-08,0.019452982,-0.008652778,0.07715533,-0.01704684,0.053097278,0.020179993,0.0026631826,-0.033277728,0.024851786,0.008881777,-0.020428983,0.08412149,0.04081038,0.013058193,0.08391569,-0.006079934,-0.08707293,-0.006659951,-0.0020518836,0.018488364,-0.017200911,-0.06865145,-0.08589496,0.059708484,-0.071972996,0.0013245607,0.010504599,-0.027533125,0.040348593,-0.004925831,-0.052604232,0.028764915,-0.03214028,-0.06445543,-0.08527503,0.0027457178,-0.052248597,-0.022878254,-0.030462798,0.017676061,0.10213439,-0.02506929,-0.0015303602,0.020430796,-0.048455656,0.009201521,-0.001636435,0.034117043,0.03614022,0.019870244,0.055460278,0.018388012,-0.046029124,-0.03902704,-0.16540869,-0.019503603,0.029769415,-0.087951764,-0.030252483,0.0022551522,-0.073820874,-0.025840722,0.10463972,-0.010390352 +4.2.1.122,"Most mesophilic bacteria have a multimeric tryptophan synthase complex (EC 4.2.1.20) that forms L-tryptophan from L-serine and 1-C-(indol-3-yl)glycerol 3-phosphate via an indole intermediate. This intermediate, which is formed by the alpha subunits, is transferred in an internal tunnel to the beta units, which convert it to tryptophan. In thermophilic organisms the high temperature enhances diffusion and causes the loss of indole. This enzyme, which does not combine with the alpha unit to form a complex, salvages the lost indole back to L-tryptophan. It has a much lower Km for indole than the beta subunit of EC 4.2.1.20.",384,1.0,0.013273122,-0.10202681,-0.012211274,0.036849026,0.03356343,0.045294542,0.0019715917,0.007407993,0.09557963,0.051767334,0.017583448,-0.06502051,-0.057372246,0.14612396,-0.012158644,-0.044041824,-0.013530781,0.008027306,-0.05702691,-0.043431856,0.022587672,0.059235837,-0.040741462,-0.029421404,-0.02121062,-0.005110585,0.0076656695,-0.090765566,-0.047475703,0.00049238413,-0.051068567,-0.053588096,0.08741227,-0.0058747404,0.06439689,0.07015375,-0.048979625,-0.06441214,0.09024576,-0.006658445,-0.03358975,-0.0018725686,0.0060818167,0.011912128,-0.013972102,0.051348533,0.046471015,-0.0148896165,0.08349847,-0.08187357,-0.035380688,-0.034580186,-0.01104025,0.055444285,-0.011526376,0.04533994,-0.027997987,0.06642923,-0.047938306,0.06073845,-0.012908709,0.08527974,0.027864523,-0.0200181,0.0075404933,-0.071027815,0.0604633,-0.038049165,-0.009723145,0.04599966,-0.036335614,-0.0001644776,-0.0419098,-0.004249312,0.03887527,0.0036062503,0.013148399,-0.051055606,-9.0826514e-05,-0.036734805,0.024404384,-0.014695831,-0.02243514,0.067235954,-0.05396459,-0.05708922,0.07812481,0.008701384,0.040956136,-0.02227863,0.025346402,-0.030103302,-0.0852425,-0.04354511,0.051605463,-0.0062703537,-0.0048963875,0.005624044,0.03393452,-0.08939901,-0.009645063,0.012003094,-0.08015156,-0.08290202,-0.009765527,-0.026145937,0.068568006,0.042725954,0.07552958,0.060635895,0.001549092,-0.008205206,0.09156669,0.038894847,-0.0026402683,-0.018712183,-0.038791146,0.005086268,-0.08553942,0.04280795,-0.031954616,-0.002372716,0.05064303,0.070281684,-0.105967574,0.062307343,-0.021843994,5.510956e-34,0.11042084,0.058562767,0.0033715153,0.008954639,-0.0022705658,-0.03669916,-0.07466461,-0.054763857,-0.0036575398,-0.021374868,-0.01420941,-0.08555916,0.0067742853,0.00867401,0.004530078,0.053209934,-0.16798444,0.01249256,0.022429138,0.03666115,-0.057809982,0.044614617,0.024080835,-0.024809893,0.015167177,0.0522163,0.038894482,-0.0125711365,0.030040173,0.001396601,0.0066903993,-0.08079235,-0.1588953,0.052919816,0.035435792,0.027074741,-0.040456716,-0.02789629,-0.009576936,-0.0015744573,-0.014676366,0.11106614,0.044305436,0.030820128,0.086780116,0.03833851,-0.039739024,0.12952867,0.019281872,-0.00071325304,-0.01151326,-0.038821824,0.025596457,-0.071261115,-0.027398877,-0.053193558,0.01676393,0.024931896,0.015167816,0.017094875,-0.0467164,0.064528376,-0.04294675,0.020241262,0.002021087,0.04250583,-0.092069,-0.060243957,0.014896569,0.03722457,-0.019381708,-0.039370827,0.05729164,0.010364452,-0.02266702,-0.040779933,-0.007024581,-0.02213108,0.020574283,-0.041768212,-0.0109792,-0.016126333,0.032126777,-0.07591479,0.0130297,-0.07062787,0.0056698946,-0.023411144,0.0018803716,0.029993441,0.07954271,-0.062304497,-0.05252629,0.12646544,-0.04918344,-1.3955584e-33,0.051192366,-0.12350272,-0.0027008427,-0.04984211,-0.08424646,0.017654685,0.011755223,0.012515206,0.04686917,-0.0077666333,0.06848526,-0.027520591,0.070757076,-0.017348759,0.027228417,-0.10878676,0.008494828,0.098807625,-0.0019759068,-0.050043657,0.012810574,0.016757855,-0.0065089,0.026368933,0.02991296,0.037195437,-0.09738961,0.102457926,-0.03662749,-0.0026245632,0.095792174,-0.065170825,-0.13640837,-0.027344193,0.020249521,0.046813074,-0.038517203,-0.001299957,0.036949422,0.00042851167,0.0008575379,0.04448884,0.06422827,-0.02227697,0.057350922,0.10439567,-0.03498704,-0.013064181,0.071535684,-0.02605778,-0.0026101354,-0.129459,-0.055722136,-0.05832844,0.024274644,0.029007671,-0.028644884,0.06489687,-0.02974185,-0.091437556,-0.050231036,-0.06621556,0.13344027,0.01879659,-0.06531139,0.062803075,0.050123036,0.04788192,0.102074556,-0.011371551,0.025460698,-0.02944646,0.07780695,-0.008301745,-0.01981826,-0.043006934,-0.055054326,-0.03155403,0.06378769,-0.012339053,0.010253557,0.10556719,-0.05584357,-0.039541002,0.09832281,-0.05939736,0.024198657,0.11863725,0.017652724,0.016376637,-0.014818479,0.0036627273,0.022420209,0.013258112,0.07152741,-4.3939995e-08,0.08562355,-0.032275207,0.0447266,0.0058417986,0.026753709,-0.0073685944,-0.016282616,0.061555058,0.07341001,-0.034729753,-0.012793345,0.07352919,0.01194487,0.008002525,0.013778901,-0.030860595,-0.05373875,-0.01597751,0.007491929,-0.08633044,-0.07435309,-0.07138,-0.033237137,0.049022183,0.008394441,-0.0145886475,0.04318199,-0.007214909,-0.061422504,-0.055321418,-0.033477377,0.045472823,-0.01783566,0.0141576035,-0.07204363,0.03185079,-0.02029497,0.12148122,-0.018641077,0.023911078,0.032040704,-0.061584517,-0.060949296,0.0260299,0.051149517,-0.03482234,-0.014701489,0.030650275,-0.026526812,-0.03524588,0.0658893,-0.008082836,-0.019296221,0.023188468,-0.10414029,-0.04065667,-0.056037545,-0.010687277,0.009793196,-0.0045727976,0.008092662,0.00937519,0.042399824,0.01658229 +4.2.1.123,The reaction occurs in the reverse direction.,384,1.0,-0.06124239,-0.009074832,-0.009588639,0.049501892,-0.008377073,0.0018755858,-0.019813286,0.015272959,0.0658959,0.08554592,0.074549094,0.020646635,-0.0092534,-0.009077209,-0.07307729,0.022695607,-0.025622724,0.027359664,0.01675889,0.018139893,-0.016321773,-0.036707543,-0.0053735366,0.021075834,-0.04282217,0.07697762,0.020473575,-0.0014042504,0.0019725233,-0.0593573,0.00812855,0.037264753,-0.038850456,-0.008933064,-0.1013134,0.00485833,-0.09395424,0.00069175096,0.034618653,0.05359633,0.005265703,-0.032589816,-0.0076001678,-0.069450065,0.02300235,0.009064262,-0.049552564,0.029309068,0.0816356,0.006490676,0.016176915,0.0038280752,-0.11302361,0.045143947,-0.0111015085,0.03865975,0.007077246,0.016260788,0.0018933606,0.018652825,0.04467043,-0.05036729,-0.108953014,0.007573521,0.1118531,-0.07461257,0.0011025342,-0.03206907,0.037642136,-0.0055849454,0.046905536,-0.020604763,-0.014133851,-0.095418565,0.024244798,-0.03065856,0.04089398,0.028988741,0.012551745,0.06416417,0.028197022,-0.029585268,0.024442125,0.033828445,0.02078937,-0.014660357,-0.035469934,-0.013956681,0.06358451,0.05565526,-0.07862847,-0.011511215,0.02509474,-0.015533513,-0.022631936,0.008605653,0.028409367,0.035291325,0.07602059,-0.002236588,0.00041889623,0.02853116,-0.09056182,-0.06860239,-0.0004225455,0.004144156,-0.029925475,0.06658509,-0.0051507913,0.03708592,-0.019430464,-0.012871941,0.0879955,0.035394967,-0.026143553,0.023792917,-0.0016280328,-0.015524606,-0.08689618,-0.081855245,0.01577205,-0.023588741,-0.061541922,0.0005672221,-0.021986002,-0.011525533,-0.024618683,-6.648881e-33,0.017790701,-0.010833535,0.06053331,-0.032414947,-0.014260935,-0.024987949,-0.044973306,-0.028258521,-0.023191657,0.0061152936,0.016817888,-0.009029195,0.0097417,0.0676626,-0.13638996,-0.049467694,-0.019150507,0.063832134,-0.06860726,-0.078662835,-0.025852185,0.08886818,-0.06697789,-0.030942192,-0.022890627,0.060448583,-0.050492596,-0.050065048,-0.043740727,-0.0220091,0.049882606,0.016096508,-0.086206585,0.01692739,0.056503475,0.05619458,-0.023593897,-0.027040377,0.019214476,0.027370235,-0.05526398,0.022621455,-0.10448952,0.011276798,0.0727226,-0.036982827,0.005084578,0.03991681,0.059739064,0.0019727102,0.05107746,-0.03464254,0.07038275,0.01992059,0.039455403,0.0756328,0.042925835,0.0044337474,-0.017128797,0.06444332,0.019010719,0.093041316,-0.038392615,0.026686363,-0.047215864,0.02047019,-0.041452065,-0.030939607,0.017704675,-0.008169685,-0.03698007,0.023195928,0.039581202,0.0012198869,-0.017155824,0.018224265,-0.049920976,0.03395749,0.06706526,-0.031547084,-0.05643878,-0.022350114,-0.003973737,-0.017650062,-0.05076261,0.0025559,-0.01374242,-0.09804145,0.005661727,0.047145046,0.0772662,-0.034215514,0.06754259,0.044440363,0.051042747,3.7932997e-33,0.0064166854,-0.06059205,-0.10062998,-0.017153833,-0.0436218,0.030310173,0.04971009,-0.04028669,0.032626256,0.041894812,0.049292665,-0.010546607,-0.059113033,0.051940054,0.018198583,0.046342712,0.08153009,0.10289907,-0.0012273412,-0.058257494,-0.057868496,0.064892955,0.07273815,0.023689575,0.063386485,-0.0002074312,0.12926173,0.025210137,0.019099006,0.020923562,0.0028501847,-0.05198562,0.010924387,0.035759173,-0.016968384,0.061644822,-0.063952394,-0.049937874,0.021441206,-0.08499003,0.017581452,-0.009340214,0.099059165,0.0916811,-0.02187401,-0.0271902,-0.03984772,0.019914858,0.01700698,-0.0638477,0.028469222,0.023500519,-0.013002308,-0.014609013,0.032538746,0.061564606,0.053565957,-0.019806817,0.06620334,0.0057317847,0.0014830476,-0.022864748,0.09672319,-0.12100303,-0.0063245553,0.07447717,-0.06569424,0.041486036,0.10866545,-0.059599183,0.17156634,0.14771672,0.002327124,-0.07771774,0.030036906,-0.08212625,-0.03882555,-0.029265305,-0.040084936,-0.03151416,-0.10939806,0.041326534,0.053382494,-0.017808475,-0.0912786,-0.14084247,-0.047570072,0.042048544,-0.037749954,0.031410843,0.000656546,-0.01689245,0.059852384,0.0063594407,0.13047186,-1.952278e-08,-0.043653883,-0.059696786,0.09776431,0.03667593,-0.021240564,0.11164268,0.07227898,-0.0041131554,-0.054392204,-0.121366985,-0.035403717,0.12732075,0.10411645,0.044064756,0.029094927,0.040618863,-0.050625265,-0.069245644,-0.054589454,-0.034987595,-0.054728657,-0.045293204,0.0121272635,0.057923216,-0.00046560366,0.006643224,-0.007123614,0.059545085,-0.06238645,-0.052610293,0.004240365,-0.024140667,-0.08759634,-0.02688263,0.02260654,0.04627531,0.013163201,-0.010123053,0.05203414,-0.0800069,-0.0971793,0.009906912,-0.06442625,0.06212002,-0.06657575,0.042306874,0.022055803,-0.018403864,-0.043446645,-0.005611935,0.06074111,-0.07040704,0.04488094,-0.004936968,0.0074303453,0.032121636,-0.036049917,-0.031165894,-0.012897979,0.041225214,0.01725512,0.07315602,0.115761235,-0.017769357 +4.2.1.124,The reaction occurs in the reverse direction.,384,1.0,-0.06124239,-0.009074832,-0.009588639,0.049501892,-0.008377073,0.0018755858,-0.019813286,0.015272959,0.0658959,0.08554592,0.074549094,0.020646635,-0.0092534,-0.009077209,-0.07307729,0.022695607,-0.025622724,0.027359664,0.01675889,0.018139893,-0.016321773,-0.036707543,-0.0053735366,0.021075834,-0.04282217,0.07697762,0.020473575,-0.0014042504,0.0019725233,-0.0593573,0.00812855,0.037264753,-0.038850456,-0.008933064,-0.1013134,0.00485833,-0.09395424,0.00069175096,0.034618653,0.05359633,0.005265703,-0.032589816,-0.0076001678,-0.069450065,0.02300235,0.009064262,-0.049552564,0.029309068,0.0816356,0.006490676,0.016176915,0.0038280752,-0.11302361,0.045143947,-0.0111015085,0.03865975,0.007077246,0.016260788,0.0018933606,0.018652825,0.04467043,-0.05036729,-0.108953014,0.007573521,0.1118531,-0.07461257,0.0011025342,-0.03206907,0.037642136,-0.0055849454,0.046905536,-0.020604763,-0.014133851,-0.095418565,0.024244798,-0.03065856,0.04089398,0.028988741,0.012551745,0.06416417,0.028197022,-0.029585268,0.024442125,0.033828445,0.02078937,-0.014660357,-0.035469934,-0.013956681,0.06358451,0.05565526,-0.07862847,-0.011511215,0.02509474,-0.015533513,-0.022631936,0.008605653,0.028409367,0.035291325,0.07602059,-0.002236588,0.00041889623,0.02853116,-0.09056182,-0.06860239,-0.0004225455,0.004144156,-0.029925475,0.06658509,-0.0051507913,0.03708592,-0.019430464,-0.012871941,0.0879955,0.035394967,-0.026143553,0.023792917,-0.0016280328,-0.015524606,-0.08689618,-0.081855245,0.01577205,-0.023588741,-0.061541922,0.0005672221,-0.021986002,-0.011525533,-0.024618683,-6.648881e-33,0.017790701,-0.010833535,0.06053331,-0.032414947,-0.014260935,-0.024987949,-0.044973306,-0.028258521,-0.023191657,0.0061152936,0.016817888,-0.009029195,0.0097417,0.0676626,-0.13638996,-0.049467694,-0.019150507,0.063832134,-0.06860726,-0.078662835,-0.025852185,0.08886818,-0.06697789,-0.030942192,-0.022890627,0.060448583,-0.050492596,-0.050065048,-0.043740727,-0.0220091,0.049882606,0.016096508,-0.086206585,0.01692739,0.056503475,0.05619458,-0.023593897,-0.027040377,0.019214476,0.027370235,-0.05526398,0.022621455,-0.10448952,0.011276798,0.0727226,-0.036982827,0.005084578,0.03991681,0.059739064,0.0019727102,0.05107746,-0.03464254,0.07038275,0.01992059,0.039455403,0.0756328,0.042925835,0.0044337474,-0.017128797,0.06444332,0.019010719,0.093041316,-0.038392615,0.026686363,-0.047215864,0.02047019,-0.041452065,-0.030939607,0.017704675,-0.008169685,-0.03698007,0.023195928,0.039581202,0.0012198869,-0.017155824,0.018224265,-0.049920976,0.03395749,0.06706526,-0.031547084,-0.05643878,-0.022350114,-0.003973737,-0.017650062,-0.05076261,0.0025559,-0.01374242,-0.09804145,0.005661727,0.047145046,0.0772662,-0.034215514,0.06754259,0.044440363,0.051042747,3.7932997e-33,0.0064166854,-0.06059205,-0.10062998,-0.017153833,-0.0436218,0.030310173,0.04971009,-0.04028669,0.032626256,0.041894812,0.049292665,-0.010546607,-0.059113033,0.051940054,0.018198583,0.046342712,0.08153009,0.10289907,-0.0012273412,-0.058257494,-0.057868496,0.064892955,0.07273815,0.023689575,0.063386485,-0.0002074312,0.12926173,0.025210137,0.019099006,0.020923562,0.0028501847,-0.05198562,0.010924387,0.035759173,-0.016968384,0.061644822,-0.063952394,-0.049937874,0.021441206,-0.08499003,0.017581452,-0.009340214,0.099059165,0.0916811,-0.02187401,-0.0271902,-0.03984772,0.019914858,0.01700698,-0.0638477,0.028469222,0.023500519,-0.013002308,-0.014609013,0.032538746,0.061564606,0.053565957,-0.019806817,0.06620334,0.0057317847,0.0014830476,-0.022864748,0.09672319,-0.12100303,-0.0063245553,0.07447717,-0.06569424,0.041486036,0.10866545,-0.059599183,0.17156634,0.14771672,0.002327124,-0.07771774,0.030036906,-0.08212625,-0.03882555,-0.029265305,-0.040084936,-0.03151416,-0.10939806,0.041326534,0.053382494,-0.017808475,-0.0912786,-0.14084247,-0.047570072,0.042048544,-0.037749954,0.031410843,0.000656546,-0.01689245,0.059852384,0.0063594407,0.13047186,-1.952278e-08,-0.043653883,-0.059696786,0.09776431,0.03667593,-0.021240564,0.11164268,0.07227898,-0.0041131554,-0.054392204,-0.121366985,-0.035403717,0.12732075,0.10411645,0.044064756,0.029094927,0.040618863,-0.050625265,-0.069245644,-0.054589454,-0.034987595,-0.054728657,-0.045293204,0.0121272635,0.057923216,-0.00046560366,0.006643224,-0.007123614,0.059545085,-0.06238645,-0.052610293,0.004240365,-0.024140667,-0.08759634,-0.02688263,0.02260654,0.04627531,0.013163201,-0.010123053,0.05203414,-0.0800069,-0.0971793,0.009906912,-0.06442625,0.06212002,-0.06657575,0.042306874,0.022055803,-0.018403864,-0.043446645,-0.005611935,0.06074111,-0.07040704,0.04488094,-0.004936968,0.0074303453,0.032121636,-0.036049917,-0.031165894,-0.012897979,0.041225214,0.01725512,0.07315602,0.115761235,-0.017769357 +4.2.1.125,The reaction occurs in the reverse direction.,384,1.0,-0.06124239,-0.009074832,-0.009588639,0.049501892,-0.008377073,0.0018755858,-0.019813286,0.015272959,0.0658959,0.08554592,0.074549094,0.020646635,-0.0092534,-0.009077209,-0.07307729,0.022695607,-0.025622724,0.027359664,0.01675889,0.018139893,-0.016321773,-0.036707543,-0.0053735366,0.021075834,-0.04282217,0.07697762,0.020473575,-0.0014042504,0.0019725233,-0.0593573,0.00812855,0.037264753,-0.038850456,-0.008933064,-0.1013134,0.00485833,-0.09395424,0.00069175096,0.034618653,0.05359633,0.005265703,-0.032589816,-0.0076001678,-0.069450065,0.02300235,0.009064262,-0.049552564,0.029309068,0.0816356,0.006490676,0.016176915,0.0038280752,-0.11302361,0.045143947,-0.0111015085,0.03865975,0.007077246,0.016260788,0.0018933606,0.018652825,0.04467043,-0.05036729,-0.108953014,0.007573521,0.1118531,-0.07461257,0.0011025342,-0.03206907,0.037642136,-0.0055849454,0.046905536,-0.020604763,-0.014133851,-0.095418565,0.024244798,-0.03065856,0.04089398,0.028988741,0.012551745,0.06416417,0.028197022,-0.029585268,0.024442125,0.033828445,0.02078937,-0.014660357,-0.035469934,-0.013956681,0.06358451,0.05565526,-0.07862847,-0.011511215,0.02509474,-0.015533513,-0.022631936,0.008605653,0.028409367,0.035291325,0.07602059,-0.002236588,0.00041889623,0.02853116,-0.09056182,-0.06860239,-0.0004225455,0.004144156,-0.029925475,0.06658509,-0.0051507913,0.03708592,-0.019430464,-0.012871941,0.0879955,0.035394967,-0.026143553,0.023792917,-0.0016280328,-0.015524606,-0.08689618,-0.081855245,0.01577205,-0.023588741,-0.061541922,0.0005672221,-0.021986002,-0.011525533,-0.024618683,-6.648881e-33,0.017790701,-0.010833535,0.06053331,-0.032414947,-0.014260935,-0.024987949,-0.044973306,-0.028258521,-0.023191657,0.0061152936,0.016817888,-0.009029195,0.0097417,0.0676626,-0.13638996,-0.049467694,-0.019150507,0.063832134,-0.06860726,-0.078662835,-0.025852185,0.08886818,-0.06697789,-0.030942192,-0.022890627,0.060448583,-0.050492596,-0.050065048,-0.043740727,-0.0220091,0.049882606,0.016096508,-0.086206585,0.01692739,0.056503475,0.05619458,-0.023593897,-0.027040377,0.019214476,0.027370235,-0.05526398,0.022621455,-0.10448952,0.011276798,0.0727226,-0.036982827,0.005084578,0.03991681,0.059739064,0.0019727102,0.05107746,-0.03464254,0.07038275,0.01992059,0.039455403,0.0756328,0.042925835,0.0044337474,-0.017128797,0.06444332,0.019010719,0.093041316,-0.038392615,0.026686363,-0.047215864,0.02047019,-0.041452065,-0.030939607,0.017704675,-0.008169685,-0.03698007,0.023195928,0.039581202,0.0012198869,-0.017155824,0.018224265,-0.049920976,0.03395749,0.06706526,-0.031547084,-0.05643878,-0.022350114,-0.003973737,-0.017650062,-0.05076261,0.0025559,-0.01374242,-0.09804145,0.005661727,0.047145046,0.0772662,-0.034215514,0.06754259,0.044440363,0.051042747,3.7932997e-33,0.0064166854,-0.06059205,-0.10062998,-0.017153833,-0.0436218,0.030310173,0.04971009,-0.04028669,0.032626256,0.041894812,0.049292665,-0.010546607,-0.059113033,0.051940054,0.018198583,0.046342712,0.08153009,0.10289907,-0.0012273412,-0.058257494,-0.057868496,0.064892955,0.07273815,0.023689575,0.063386485,-0.0002074312,0.12926173,0.025210137,0.019099006,0.020923562,0.0028501847,-0.05198562,0.010924387,0.035759173,-0.016968384,0.061644822,-0.063952394,-0.049937874,0.021441206,-0.08499003,0.017581452,-0.009340214,0.099059165,0.0916811,-0.02187401,-0.0271902,-0.03984772,0.019914858,0.01700698,-0.0638477,0.028469222,0.023500519,-0.013002308,-0.014609013,0.032538746,0.061564606,0.053565957,-0.019806817,0.06620334,0.0057317847,0.0014830476,-0.022864748,0.09672319,-0.12100303,-0.0063245553,0.07447717,-0.06569424,0.041486036,0.10866545,-0.059599183,0.17156634,0.14771672,0.002327124,-0.07771774,0.030036906,-0.08212625,-0.03882555,-0.029265305,-0.040084936,-0.03151416,-0.10939806,0.041326534,0.053382494,-0.017808475,-0.0912786,-0.14084247,-0.047570072,0.042048544,-0.037749954,0.031410843,0.000656546,-0.01689245,0.059852384,0.0063594407,0.13047186,-1.952278e-08,-0.043653883,-0.059696786,0.09776431,0.03667593,-0.021240564,0.11164268,0.07227898,-0.0041131554,-0.054392204,-0.121366985,-0.035403717,0.12732075,0.10411645,0.044064756,0.029094927,0.040618863,-0.050625265,-0.069245644,-0.054589454,-0.034987595,-0.054728657,-0.045293204,0.0121272635,0.057923216,-0.00046560366,0.006643224,-0.007123614,0.059545085,-0.06238645,-0.052610293,0.004240365,-0.024140667,-0.08759634,-0.02688263,0.02260654,0.04627531,0.013163201,-0.010123053,0.05203414,-0.0800069,-0.0971793,0.009906912,-0.06442625,0.06212002,-0.06657575,0.042306874,0.022055803,-0.018403864,-0.043446645,-0.005611935,0.06074111,-0.07040704,0.04488094,-0.004936968,0.0074303453,0.032121636,-0.036049917,-0.031165894,-0.012897979,0.041225214,0.01725512,0.07315602,0.115761235,-0.017769357 +4.2.1.126,"This enzyme, along with EC 2.7.1.170, anhydro-N-acetylmuramic acid kinase, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling.",384,1.0,-0.10812828,-0.040965416,-0.13850321,-0.046493217,0.030462809,0.04199432,-0.032277204,0.07487892,0.02764563,-0.001521153,0.040714115,-0.066483766,-0.08034297,0.052497786,-0.0706501,0.035948087,0.006432884,-0.068142496,0.041956246,-0.063106395,0.012553591,-0.012693858,-0.011443922,-0.048221663,-0.016047731,-0.008548415,0.07171094,0.08459136,-0.03895732,-0.07418214,0.008334078,-0.068337895,0.10125911,-0.02129277,0.07424319,0.07425605,-0.06253688,-0.11551644,0.044000875,0.03974599,0.086481124,-0.026724568,-0.05518534,-0.030686999,0.033726886,-0.011245913,0.04723895,0.05284674,0.094003744,-0.035991248,-0.053322047,-0.035138838,0.010788226,0.007721953,-0.035006892,0.058515415,-0.024377597,-0.02837257,-0.0042551653,0.02954799,0.06242287,-0.023145767,-0.003843374,-0.000374832,-0.07648692,-0.07613486,0.053208355,-0.061755225,-0.038006403,0.0032820362,-0.09502967,-0.035324544,0.07003376,0.07573475,0.012872119,0.036136955,-0.03701509,-0.081266865,0.025519324,-0.08028318,0.01696714,-0.04066442,-0.0648211,0.023746634,0.0011513964,-0.018810663,0.04572729,-0.00021350225,0.034169137,0.024561794,0.06257799,-0.05891811,0.048669156,-0.06292103,-0.08261234,0.05110085,-0.019626532,0.0147261815,0.027980134,0.00010044744,-0.05013034,0.053015932,0.048906412,-0.087417506,-0.04893744,0.032383528,-0.025235284,0.11249836,0.08064209,0.010861154,-0.04655543,-0.012588952,0.027703473,0.039621036,0.012674882,0.098305196,-0.024454419,-0.09720923,-0.02872601,0.011048454,0.044375863,-0.092457294,0.0105290655,0.06313208,-0.050758176,0.089361034,-0.060776774,1.1109606e-33,0.08195025,0.0072327666,0.03545366,-0.025395893,-0.03066619,-0.0021902772,-0.06772582,-0.030767402,0.023153901,-0.16538388,-0.071360976,-0.09824945,0.028332757,0.04012096,-0.023646211,0.02004227,0.012126665,-0.012685903,0.0574396,0.067704126,0.027832579,-0.016441502,-0.029575296,-0.014117107,0.069131985,0.045346197,0.011473145,-0.027496101,0.0074825264,0.0001258899,-0.012765827,-0.019394783,-0.054561224,0.050940823,0.09231945,-0.022353347,-0.023281896,-0.00051098294,0.036814015,0.026785586,-0.0014269281,0.081797324,0.048031624,0.04496163,0.063002124,-0.042716928,-0.02621991,0.12658344,0.048853666,0.050407846,0.06566328,-0.04379894,0.08327752,-0.05060174,-0.017621271,0.03451145,-0.061009403,0.0060084467,0.07912172,-0.028144093,0.021065507,0.043937996,-0.060531713,0.07635595,-0.032751955,0.027811531,-0.07882908,-0.022318851,0.015671398,0.008187068,-0.05462954,0.027572516,0.052635636,0.039171662,-0.06690216,-0.023018757,-0.056047928,0.01824952,0.001687744,-0.033529535,-0.0650284,0.03250408,-0.015189452,-0.011613243,-0.083795615,0.00837349,0.026453035,-0.043589097,-0.020659134,-0.012377792,0.095738545,-0.034531374,-0.05457183,0.02572175,-0.011839793,-2.7802008e-33,0.107780784,-0.06524276,0.022701442,-0.05180621,-0.03713742,0.11410494,0.05293331,-0.015044621,-0.019878127,-0.013725773,0.03214725,0.008050118,0.07560645,-0.08661723,0.09432493,-0.005457982,-0.03445307,0.074610986,-0.054232143,-0.042533793,0.02715342,0.026376741,0.07852352,-0.0070472164,0.04169521,0.0057295724,-0.072207496,0.062289912,-0.011404185,0.04923605,-0.056202285,0.021718336,-0.03817114,-0.06545481,0.014673831,0.026795834,0.008927529,-0.020709101,0.025356388,-0.03199119,0.022170035,0.07355548,-0.03204599,0.07887861,-0.015257082,0.11941578,0.024827989,-0.021054843,0.012651533,-0.1158845,0.0030664667,-0.0334984,-0.033430368,-0.020481884,-0.009574439,0.10804725,-0.01728675,0.05457039,-0.0033826777,-0.06444519,-0.04230047,-0.05857152,0.047374662,-0.014533148,0.029420221,0.026635073,0.010914994,0.030485177,0.034998223,-0.014684027,0.056298375,0.044373546,-0.017282236,0.04336259,-0.02248737,-0.013386658,-0.09207485,-0.03914931,-0.030971082,0.042359624,-0.053623453,0.0052710287,-0.062335268,-0.033772353,0.009564793,-0.06552294,0.0769799,0.013706003,-0.030057753,0.031955503,-0.0050989334,-0.03246965,-0.10053321,0.06279301,0.008530357,-3.7721467e-08,0.09185219,-0.08187317,0.06974759,-0.04312877,0.07527362,-0.014475576,-0.00837213,0.02580482,0.1007281,-0.027971048,-0.013740648,0.07599055,0.027076075,0.029685698,-0.029167442,0.05378344,-0.008795981,0.014063429,-0.03871973,0.009544869,-0.03615994,-0.059519064,-0.103928685,0.047542103,0.049251854,-0.06925853,-0.05267701,0.03436725,-0.030398637,-0.062259935,-0.03796271,-0.0028647655,-0.0005747328,-0.042657558,-0.00592188,0.06848344,0.015929878,-0.0069104107,0.0022301015,0.003580969,0.036672827,-0.039107315,-0.049457796,0.026227329,0.0327117,0.015503135,-0.023272157,0.0048819827,-0.06855978,-0.02198602,0.023323597,-0.041247305,-0.007560124,-0.056672983,-0.10327381,-0.0070902756,-0.019174729,-0.08014949,-0.0027009293,-0.038288575,0.041008066,0.054926027,0.12982146,0.00843324 +4.2.3.74,"Requires Mg2+. Presilphiperfolan-8beta-ol is the precursor of botrydial, a phytotoxic sesquiterpene metabolite secreted by the fungus Botryotinia fuckeliana (Botrytis cinerea), the causal agent of gray mold disease in plants.",384,0.99999994,-0.05317133,0.01920469,-0.006811939,0.030436194,0.011593022,0.024533177,-0.01762197,0.08789321,0.014241399,0.082276054,0.09701494,-0.040083777,-0.01284378,-0.00777867,-0.030563632,-0.00812507,-0.023198789,0.03035616,-0.05449405,-0.017590716,0.12028837,0.08575392,-0.018523915,-0.018734846,-0.01853122,-0.008041753,0.0020189849,-0.0016960793,0.03499743,-0.063520856,-0.006112522,0.020434404,0.078820154,-0.034243558,0.008510423,0.05515046,-0.003844775,-0.0125365835,0.038681235,0.0031194736,-0.01578367,-0.06242151,-0.0053467765,0.044152122,-0.08598415,-0.03670265,0.0103805335,0.026906976,0.042491086,-0.0018869863,-0.06435912,-0.011921026,0.021045478,-0.062386982,0.007665229,-0.025084432,0.056931473,-0.050249863,0.010062788,0.024957411,0.010924625,-0.000856939,0.021422405,0.0021595033,-0.013978115,0.075413756,-0.023748608,-0.074546084,0.0005525321,-0.008550748,0.037435383,-0.036754876,-0.043072596,-0.033029012,0.018582558,0.12169881,-0.021627486,-0.08096429,0.041508097,-0.012647934,0.050471745,0.11569047,0.10828138,0.05354711,0.015981523,0.04977732,0.012029871,0.03981906,-0.01722594,0.080178,0.050545316,0.016232893,0.0060173674,0.091009974,-0.06603588,0.08052545,-0.05202441,-0.037458047,-0.028260456,0.0154870525,-0.040947616,-0.07031668,-0.119468205,-0.01172268,-0.021153266,0.004100226,0.06972837,-0.0643227,0.01313315,0.049008828,-0.009549551,-0.004520874,0.009942076,0.017769152,-0.039680593,-0.013573552,0.07501486,-0.0023984823,0.044644225,-0.034320682,0.05576334,0.0048870696,-0.054755937,-0.03445362,-0.03712347,-0.0773705,-0.029875195,5.2937506e-33,0.06252186,-0.014543434,-0.0056957216,0.08113618,0.02071206,0.0184591,-0.024669245,-0.02956075,0.012568995,-0.11334548,-0.09889401,-0.08330542,-0.13608587,0.05114527,-0.09777355,0.016334882,-0.01368874,0.016470252,0.07571093,-0.030540075,0.034490123,0.040326912,0.0012030969,-0.055566963,-0.0043192254,0.11169544,-0.019582942,-0.07220364,0.06843358,-0.007313211,0.042918656,-0.07849375,-0.028760346,0.015638508,-0.021914678,-0.00021593957,-0.004625631,-0.032535724,-0.10911252,-0.025723133,-0.07862884,0.086733356,-0.0014766202,-0.050960787,0.06652109,-0.047001176,-0.11093337,0.07128799,0.016172167,0.017985474,0.03910366,0.045796316,0.041341364,0.113566376,0.011647557,-0.03830916,-0.04192354,-0.01301181,0.049512018,-0.03223894,0.06323958,0.07191735,0.032070678,0.0066281557,0.084994994,-0.0080384975,-0.058158718,-0.070328616,-0.021680966,-0.0037114788,0.0016014656,-0.034714468,-0.070900664,0.052169226,-0.03767989,-0.0048197336,-0.0042042243,-0.020918218,-0.036334887,0.02844227,-0.033369407,-0.042078435,0.010291478,-0.06449696,-0.09586124,0.023392683,-0.034585737,-0.018844495,0.0059978776,-0.0393256,0.00042366996,-0.047931552,-0.12230855,0.056418493,-0.048448835,-5.333153e-33,0.026361413,-0.00896899,0.14152788,0.028706573,-0.04905273,0.015383316,-0.015922343,-0.052728247,0.029470673,0.035389636,0.014259225,-0.0043837307,0.084824495,-0.07251112,0.03405737,-0.026183892,0.06184728,0.07429484,-0.032101113,0.00015643952,-0.083347924,0.12373712,-0.056788165,0.011601386,0.0733553,0.001762384,-0.0129876565,0.045522194,-0.09630648,0.05390361,0.07713298,0.07844431,0.0046506566,-0.012071405,-0.0034098853,0.004500057,-0.0030218388,-0.04622612,0.005916848,-0.0016945475,0.008890772,-0.030566208,0.026490767,0.024079466,0.019368552,0.04844706,-0.058783427,0.06915091,0.093049176,0.027441924,0.021254852,0.027915558,-0.049428824,0.0028810552,0.06393175,-0.013083116,0.005064907,-0.029015131,0.062192548,0.034424156,0.041734755,-0.020630259,-0.017967496,-0.073686056,0.021717336,0.06257612,0.001336196,0.07176964,0.11965986,-0.014406117,0.1167801,0.08412125,-0.00053790497,0.030172443,-0.022012757,0.02449192,-0.0043995194,-0.04664084,-0.008011212,0.016335798,-0.055152826,-0.023024125,0.051176954,0.023464285,-0.02031872,-0.08092314,0.10236513,0.014146533,-0.0124640195,0.0016020254,-0.07233304,0.005629061,-0.04151526,0.07273054,0.049054854,-3.6983945e-08,0.005525776,-0.004906805,0.0409733,-0.10366007,-0.07936422,-0.06494462,-0.010058822,-0.0028319808,0.05377249,0.0030152267,0.018448757,0.019652901,-0.0045095286,-0.038479377,0.029471943,-0.059719093,0.011984375,0.082230896,-0.028745271,-0.05534315,-0.017445734,-0.05535446,-0.0699093,-0.059144687,-0.02213607,-0.12902686,0.020915186,-0.03252923,0.051122673,-0.014596579,0.045633875,0.03851546,0.08950692,-0.022149192,-0.10173505,0.07501689,-0.07874711,-0.033644132,-0.00029197676,-0.057214934,-0.024788799,-0.049009483,0.049110085,-0.076781705,-0.09392885,-0.036107387,-0.0007812168,0.05537367,-0.04454492,-0.012403488,-0.0018249315,0.07210771,0.013759759,0.043431487,-0.06422827,-0.06576912,0.044030037,0.037274707,-0.0034143694,-0.11492175,-0.009437993,-0.03333922,0.11622493,-0.027789934 +5.3.3.16,"This enzyme has been characterized from the bacterium Pseudomonas putida KT2440 and is involved in the degradation pathway of syringate and gallate. It catalyses the interconversion of two of the tautomers of 4-oxalomesaconate, a reaction that can also occur spontaneously.",384,0.99999994,0.0056963074,-0.031658463,-0.09929592,0.0062212325,-0.0032642311,-0.006146266,-0.02335775,0.053384617,0.011626577,-0.054640673,0.019480105,-0.03579038,-0.03648073,0.07667095,-0.07726154,0.1002199,-0.12894312,-0.014382553,-0.00045024528,-0.014970015,0.03017899,0.04157231,-0.010474135,0.0009307016,0.06655698,0.031220144,0.060813844,-0.03347404,-0.034987602,-0.039136466,-0.027049301,-0.113983795,-0.018150058,-0.04310524,0.03818998,0.043511786,-0.04731601,-0.02126094,0.10714726,-0.022621496,0.015546339,-0.038784746,-0.058563333,-0.0447961,-0.01903784,0.025076445,0.017488496,0.017236168,-0.008294442,-0.038976867,-0.05838502,-0.059986938,-0.035796817,0.025499517,0.03374361,0.035914935,-0.030805126,0.009016269,-0.026351294,0.0176941,0.04291419,-0.021807553,-0.0056955917,0.03372319,-0.010289472,-0.0049889362,0.09427746,-0.0030868168,0.0163959,-0.06730255,-0.06293642,-0.055277947,0.00049577665,0.05035804,0.02700096,0.025298988,0.017209217,-0.04654989,-0.0052176937,-0.027609495,0.022621082,-0.0046935314,-0.0017211395,0.06303694,-0.0064223413,-0.04425378,0.051320296,-0.03508888,0.10266572,0.025329709,-0.00039575456,0.022461308,-0.045385715,-0.021867678,-0.04337802,0.040524367,0.028792929,0.045115393,0.023571447,0.019175136,0.023518302,0.06375234,0.0031247002,-0.1264168,-0.0024546417,0.018952021,0.019198518,0.0020428502,0.054297794,0.01836857,-0.009346637,-0.0029726205,0.05921866,-0.027839039,-0.027585823,0.09914603,-0.00015572816,-0.026706867,-0.091897614,-0.035394948,-0.0004306946,-0.05421547,-0.024429234,0.03794332,-0.02020355,-0.03266146,-0.12854128,1.5331069e-33,0.06868133,0.040928304,0.038426187,-0.010746676,0.030165523,-0.008824168,-0.09986709,-0.004169361,0.01599475,-0.032035075,-0.08210313,-0.16654803,0.0029820392,-0.051430766,-0.0048294016,-0.012866427,-0.01930979,0.028647434,0.058865212,0.051679708,-0.025733575,0.063686274,-0.08374646,-0.0104644075,0.018008875,0.08727672,0.07623973,-0.034674447,-0.01115244,-0.009416689,0.06690104,-0.055590633,-0.13974133,-0.0054823305,0.052312106,-0.049361117,-0.07096688,-0.022303425,0.02535389,0.079253174,0.081584685,0.026510129,0.01670505,0.042081244,0.10976116,-0.07851911,-0.023430824,0.18786146,0.021784673,0.10871273,-0.033795588,-0.06933775,0.09323875,0.04176944,-0.027162572,0.019404726,-0.043143075,-0.024755327,0.054488663,-0.010244517,0.0100973705,0.01922324,-0.049636923,0.011032764,-0.0031029235,-0.009277563,-0.05876401,-0.03756878,-0.002346769,0.012315937,-0.08297933,0.008500543,-0.03436081,-0.005661611,-0.0037742674,-0.112070814,-0.034444198,0.068043284,0.05477838,-0.026008591,0.013848485,-0.022137823,0.024994804,-0.057979703,-0.01646323,-0.0033474388,-0.014092095,-0.027876075,-0.035864912,0.11791885,0.05437177,-0.06479753,-0.07919809,0.058437932,0.031107225,-1.689502e-33,0.09780351,-0.06982921,0.054009102,-0.007669377,-0.017512925,-0.013100427,-0.06879971,0.09953811,-0.033152185,-0.021572074,0.06921264,0.013860976,0.09346434,-0.06135414,0.03120639,0.03263198,0.014715163,0.03543459,-0.021452323,-0.016895637,0.007584747,0.08242416,-0.06907839,-0.019809686,0.058013692,0.05209481,-0.017024469,0.043525647,0.035517007,0.08701769,0.028617552,-0.004269197,-0.007008225,-0.020762574,-0.026735451,0.014565267,0.067846484,-0.01720949,0.038633257,0.017436255,0.0071226098,0.08168636,-0.008977464,0.04028012,-0.034836467,0.0693478,-0.07870527,-0.012039173,0.031745113,-0.09946567,0.030543681,-0.01250921,-0.032558285,-0.019610146,0.039663285,0.035322983,-0.03478352,0.013326537,-0.08598745,-0.075311765,-0.052499406,-0.092068724,0.12906528,-0.014784508,0.06537004,0.045923617,-0.020901788,0.048758354,-0.0008600524,-0.014221141,0.038102932,-0.010626737,-0.08801495,-0.008004089,-0.031830866,-0.015120764,-0.050784495,-0.033905793,0.0025624873,-0.020694967,-0.0077303345,-0.027262393,0.02355019,-0.077090405,-0.0017770886,-0.10192672,0.05502596,0.13841042,-0.05419145,0.026397394,0.021569079,0.023363432,-0.0050509567,0.1197771,0.041801415,-3.3893976e-08,0.0043794834,-0.06254997,-0.02629633,0.03207583,0.017519485,0.028727986,-0.012689885,0.02867047,0.03988179,-0.064061,-0.015610046,0.08672733,-0.0019481457,-0.014242354,0.07959868,-0.04968621,-0.08704083,0.015035025,-0.09043719,0.023597961,-0.013794716,-0.05358841,-0.08983594,0.05606579,0.050791707,0.002057522,0.08855687,0.06460046,-0.009967366,-0.061777372,-0.023737028,0.017696004,0.008138819,-0.044337608,-0.101755165,0.038129956,0.010719066,-0.019236593,0.00817707,0.02532965,0.030954916,-0.06707202,-0.1026492,0.03478339,0.026890233,-0.008358219,-0.016720457,0.02255983,-0.032103036,-0.020146197,0.03463017,0.026491364,0.036248423,-0.034199074,-0.07743023,0.030918472,0.042262975,0.047960956,-0.018734118,0.030430842,0.008270764,0.0010916393,0.16468123,-0.0036142867 +5.4.99.32,"(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.",384,0.99999994,-0.058894258,0.07394177,-0.13389924,-0.07000852,0.050981548,-0.026647633,-0.029228417,0.03559785,0.011592869,0.046534427,0.026573911,0.00077440904,-0.05287013,0.062451866,-0.024962097,-0.040965285,-0.0488192,-0.024664849,0.023645155,-0.00382387,-0.032296058,0.08789083,0.030829959,-0.013844291,0.02929689,0.024389626,0.018097173,0.051459495,-0.00021296367,-0.021360371,0.07994135,0.025085106,0.101838775,-0.088144675,-0.0047971713,-0.013870594,-0.091654785,-0.035215024,0.04439051,0.05864638,0.020309763,0.009697431,-0.012363607,0.0198089,0.034730144,-0.034172513,-0.10764428,0.043073926,0.098274015,0.019218154,-0.042834677,-0.07667256,0.0062296423,0.08977095,0.015708568,-0.04535655,-0.10113865,-0.042941686,-0.0009179821,-0.046729762,0.036597718,-0.039018925,-0.00746946,0.0135575775,-0.0045460705,0.01272759,0.042249855,-0.04252231,-0.008142291,0.0015783249,0.0234089,0.031429455,0.028974963,0.084053636,-0.044534232,0.06993577,0.073563725,-0.060489334,-0.020375054,-0.067420155,0.07662807,0.023339165,-0.009822587,0.15250692,-0.016348118,-0.029359354,0.011248405,-0.013250903,0.008589849,0.06808701,-0.0016197003,0.013605539,-0.07136782,0.0015044848,-0.031373266,0.021142228,-0.0021403653,-0.061573286,0.018223183,0.02769697,-0.000621295,0.048444077,0.024229199,-0.027113438,-0.07049593,0.07275239,0.00010089109,0.03276181,-0.023110658,0.065433666,0.056950435,-0.055479646,0.011351189,-0.09999522,-0.04270838,0.09573074,-0.03423324,-0.04826345,0.034442518,-0.024983637,0.00040918466,0.00043528105,0.030562924,-0.000471355,-0.025261804,0.009166265,-0.027462779,-3.0582263e-33,0.04840193,0.01751331,-0.049225118,0.04527808,0.012415109,0.05690557,-0.0059136907,-0.022015816,-0.07772665,-0.09708385,-0.14166999,-0.047649615,0.057144247,0.010187192,0.011596019,-0.005410501,0.010694156,-0.0035270578,0.03442947,-0.015302193,0.037956532,0.10753486,-0.045506965,-0.06840023,0.017624624,0.0075244103,-0.03531472,0.041473527,0.040483244,-0.00618586,-0.008026137,0.032564472,0.0025758785,0.037492383,0.03343279,-0.006370818,-0.058913037,-0.0841639,0.04621078,0.013659241,0.10701695,0.02008041,-0.004045576,0.050417047,0.046531532,0.006185475,-0.05989656,0.016733525,0.07977903,0.006720444,0.03592336,0.027443133,-0.039897583,-0.026048731,-0.024594873,0.05229188,-0.09440311,0.016854376,0.093067266,0.014053795,-0.0050159474,0.061568312,-0.052435655,0.13474077,-0.03713633,-0.00919113,-0.019883089,-0.07855263,-0.009903938,-0.020208927,-0.030441267,0.011009707,0.07325071,0.025164697,0.014047602,0.054692592,0.039459527,-0.03579956,0.018830057,-0.025773402,-0.02917971,-0.004084269,-0.0807995,-0.0056615137,-0.086506836,0.08629679,-0.019006861,-0.050590962,-0.024577608,0.048539482,-0.037456322,-0.07672156,-0.07642609,-0.009605952,-0.017512964,-5.956142e-34,0.10240409,-0.057647277,0.058365162,-0.04885547,-0.03441345,0.039287075,-0.0058269342,-0.03563471,6.0013514e-05,0.003854582,0.1130679,-0.07662965,0.005552019,-0.05365356,0.09190467,5.2447205e-05,-0.0636553,0.032638896,-0.082734354,0.005822817,-0.0016438023,0.048855297,-0.040338885,0.09355902,0.016081762,0.02926461,0.051959995,-0.02434411,-0.01979826,0.116780825,-0.00881597,-0.04590206,-0.031106703,0.053519584,0.0041282927,0.13740867,-0.020110877,-0.10254768,0.026132006,-0.079004556,-0.051612318,-0.0006878748,0.042393737,0.0007478748,0.03251191,0.054216776,-0.025613671,0.08995498,0.049621474,-0.05612135,-0.010725121,0.013334353,-0.053846195,-0.012043211,0.0045411,0.019779816,-0.030379582,-0.003511484,0.02892481,-0.0586649,0.10884802,-0.095887594,0.026178641,-0.058121487,0.0044519366,0.02636132,0.027979482,-0.066706106,0.062102016,0.016471328,-0.0528302,-0.02325346,-0.05646104,0.027635915,-0.014785863,-0.043382574,-0.018729089,-0.010279059,-0.008376893,-0.00037608788,-0.022821862,-0.006840768,0.0327543,0.01911457,-0.019335927,-0.05966451,-0.026799195,0.057917662,0.033401445,0.11138399,-0.029386658,0.021870315,-0.07982953,-0.039823454,-0.02412405,-2.7883962e-08,0.11714891,-0.051585697,0.007784432,-0.0054357867,-0.08370109,-0.05800255,-0.027204413,-0.075956725,0.0916558,0.014349752,0.031054387,0.1024724,-0.013624716,-0.062565304,0.0054181316,-0.025909819,-0.095226265,0.013174426,-0.016788282,-0.08531299,-0.06632138,0.015302668,-0.026386889,-0.06208526,-0.0028703192,-0.058305167,0.01429442,0.05528199,-0.0060416646,-0.08216947,0.042009957,-0.012172349,0.0820318,-0.030762112,0.027111545,0.07542624,0.04377246,-0.039049763,0.051025163,0.018635511,0.026105814,-0.042551182,-0.0367749,0.012272318,-0.07028791,-0.029235655,-0.017885553,0.08615698,-0.110610865,-0.09348412,-0.079973675,0.03487538,0.012212684,0.0109923305,-0.016850455,-0.0054541402,-0.09245046,-0.09056824,-0.033132453,-0.00752101,0.018854434,-0.06511739,0.12661794,0.027294917 +5.4.99.34,"The enzyme produces germanicol, beta-amyrin and lupeol in the ratio 63:33:4.",384,1.0,-0.04390815,-0.12218608,-0.068549246,0.02565468,0.053942505,0.030886931,-0.080478676,0.0384531,0.05313897,-0.060207542,0.04146975,-0.06839876,-0.12693885,-0.007454847,-0.06245196,0.03412224,-0.0681774,-0.03163276,-0.05646685,-0.015690435,0.0380413,-0.038881954,0.04466349,0.017398011,0.0788174,-0.016284795,0.044483323,-0.020652778,0.0018749724,-0.031278662,0.050229844,-0.011659018,0.064471416,-0.036253452,0.019012244,-0.015429163,-0.031738754,-0.16043341,0.049457304,-0.010292392,-0.016230352,-0.032582425,-0.039411332,-0.017217368,-0.030429114,0.02149393,-0.05455277,0.055369906,0.027995074,-0.00056960946,-0.016930688,-0.06714199,-0.025570292,0.061852463,-0.0046398346,-0.017998928,-0.082586855,-0.053255472,0.016870428,0.08544948,-0.038296394,0.08282225,-0.040211592,-0.027304566,-0.053944845,-0.05060881,-0.0039970353,-0.052320424,-0.013840352,0.005526019,-0.055718083,-0.064250775,0.024815738,0.04832671,0.038147245,-0.014409665,0.013734577,-0.048599456,0.06701056,-0.06295539,-0.014519278,0.010364638,0.037938166,0.06820247,0.057610873,-0.013135522,0.06505215,0.026497819,0.066130355,0.067329355,0.021791179,-0.03710262,-0.08754289,-0.014862335,0.032286752,0.07344887,0.044422176,0.026050154,0.03850021,-0.034602,-0.02436127,0.011334572,0.031874157,-0.11860347,-0.059691533,0.06261417,0.037082713,0.081260055,0.03622778,-0.046043534,0.04049769,-0.019414227,0.044142075,0.0035938672,0.033188004,-0.0060465173,0.024769966,-0.064669505,-0.03392802,0.015431781,0.04763968,0.04798323,0.115993336,0.0941815,-0.0476895,0.044824593,-0.055065997,-1.187022e-33,0.050710693,-0.009368569,-0.059189,0.021980302,-0.019255886,-0.024233079,-0.10373396,0.032487135,-0.06261027,-0.052222867,-0.12933218,-0.046117295,-0.0064800223,0.020699421,0.056759924,0.00642803,0.06697069,0.0021556038,0.07174198,0.015910463,-0.0056012557,0.036445234,-0.027410457,-0.0060596853,0.04395263,0.030474193,-0.048078608,0.04703418,0.023417942,-0.0037552372,0.0006227884,-0.068566665,-0.005356561,0.041453738,-0.019510554,0.122796685,-0.03326911,-0.023788614,-0.035536695,0.04823868,0.10799124,0.03860083,-0.0066227783,0.008232668,0.077706054,0.04730765,-0.026211848,-0.00080271385,0.04291387,0.019695722,0.0187191,-0.02586568,0.09382065,-0.0076638437,-0.0052059707,0.092229374,-0.007476125,0.054109853,0.08094618,0.051502,-0.09247373,0.11980212,0.0117208315,0.00023460554,0.027091028,0.0053256745,-0.044269007,-0.028145028,-0.10859792,0.044378117,-0.06674572,-0.03920325,0.070906386,-0.016068421,0.05235052,-0.009070819,-0.030170541,0.008381868,0.034707494,-0.0336939,-0.03660977,0.026871983,-0.03053053,-0.004707818,-0.00794824,-0.021864263,-0.06074516,0.0029987614,0.0041351626,0.055769302,0.07420858,-0.118619785,-0.031380918,0.009390545,-0.05275733,7.764232e-35,0.04108342,-0.11036946,-0.027563715,-0.008422039,-0.073952585,0.12221279,0.03909847,-0.03410443,-0.017782986,0.025461273,0.051615916,-0.047491122,-0.020671068,-0.03922701,-0.032068476,0.0004665412,-0.0067596054,0.07919459,0.03427211,0.026929624,-0.008068677,0.09262952,0.058609944,0.03133676,-0.00043864522,0.02298094,0.05328104,0.05858558,0.0316497,-0.035675902,-0.052360497,-0.1036571,0.031506184,-0.13297342,-0.01955394,0.036886223,-0.04864176,-0.024234446,0.054398492,-0.009086696,-0.0009588601,-0.013585682,-0.025178883,0.04400036,0.06420265,0.03245141,0.025140848,-0.05282794,-0.055009056,-0.029251982,0.07734688,-0.017764196,-0.039279338,-0.0138099305,-0.03813477,-0.011426155,0.029670179,-0.0053355563,0.013338458,0.0014345549,-0.070046775,0.008498289,0.0453692,0.04272885,0.05858209,0.06233075,-0.023323707,0.11116724,0.036156844,-0.038025104,0.052264147,0.005325082,0.016715879,0.08590802,0.04044881,-0.078222804,-0.02787751,-0.03841223,0.054019816,-0.039382894,-0.00919686,0.010498624,-0.0073742196,-0.04756175,-0.059401125,-0.085909955,0.06924149,0.0955845,0.06430613,0.023266533,0.017395006,0.017218692,-0.059252907,0.02490087,0.1296119,-2.2255824e-08,3.2849866e-06,-0.03000662,0.040764634,-0.03195902,0.03427438,-0.022838634,0.040558044,0.0077924104,-0.054041833,-0.007367013,-0.043140993,0.1583149,-0.05092644,0.006652473,0.01926972,-0.04823752,-0.06669362,-0.0023492093,-0.005876468,-0.047329243,0.026289795,0.062011357,-0.018067833,-0.004222459,-0.0022057588,-0.11224166,-0.043541133,0.04355099,-0.041646212,-0.073337145,0.0043710726,0.05464866,-0.025329331,-0.020957757,-0.039463487,-0.00011425064,-0.08961826,-0.026627032,-0.008834087,0.082766786,-0.006517463,-0.10409437,-0.0073121754,-0.06410718,-0.04090082,0.039546102,-0.00453219,-0.0062302286,0.09117814,-0.021439375,0.028590549,-0.020486476,0.008044596,-0.052504655,-0.06431912,-0.06083532,-0.00056663214,-0.06873312,0.022274042,-0.09599368,0.036436394,0.015420802,0.11635334,0.034300756 +5.4.99.35,"The enzyme gives taraxerol, beta-amyrin and lupeol in the ratio 70:17:13.",384,1.0,-0.06544875,-0.112742394,-0.049329054,0.025643935,0.05084735,0.0040646247,-0.052552007,0.036103126,0.020034768,-0.03422021,0.006426538,-0.011349055,-0.09041574,0.07834574,-0.04983867,0.06723894,-0.0479032,0.021643277,-0.035148874,-0.023571488,0.049841113,-0.05998772,0.04104221,0.04484232,0.034670364,0.00670782,0.009456402,0.02162875,-0.02606183,-0.030933743,0.027354946,0.04538147,0.024656162,-0.07439863,-0.044886705,-0.020391699,-0.068547964,-0.122385316,0.008978057,-0.010486727,0.04574291,-0.019924168,-0.06529002,-0.011259525,-0.0964595,-0.06947456,-0.06743651,0.044496857,0.10339119,0.0054608276,-0.05457796,-0.094834,-0.09023206,0.032701723,0.023657959,0.004931549,-0.06330297,-0.05827885,0.033841874,0.030246273,-0.0022583846,0.029881455,-0.03954878,-0.020640882,-0.031084811,-0.0088167675,0.0005452589,-0.06781581,0.012876531,-0.008175718,-0.09599824,-0.027766285,0.004978811,0.03665678,-0.006578582,0.017897269,0.04687171,-0.044922706,0.03920196,-0.064025566,-0.023746407,-0.023867171,0.039048757,0.08829108,0.09859425,0.014526878,0.05985414,0.049328104,0.031471625,0.07571722,0.080916986,0.023916649,-0.08198566,-0.06754555,0.05120101,0.016846104,-0.03285672,-0.016210524,-0.02447997,-0.022400547,-0.015184102,0.05048424,0.014742556,-0.1142598,-0.07166482,0.022226868,0.058959413,-0.006596241,0.021596264,-0.041299734,-0.016405791,0.032485567,0.08102486,0.021810854,-0.03654461,0.04096739,0.006418917,-0.07396291,-0.008604344,0.058481112,0.04078267,0.005913812,0.10953742,0.11313073,0.004591294,-0.004805011,-0.065656684,2.173408e-34,0.05688821,0.0409941,-0.038819075,0.058499247,0.007838196,0.0258071,-0.07052262,0.055064835,-0.08205621,-0.06647224,-0.17050014,-0.07711855,0.025085127,0.04321808,0.04946729,-0.01726944,0.047146466,0.0051874756,0.059697576,0.0015762305,0.028579772,0.0532151,-0.05835924,-0.010711559,0.057011347,0.047535,-0.09568676,0.08799351,0.012301492,0.0012419064,0.013628986,-0.065807395,-0.025426714,0.091678806,-0.021020412,0.10854892,-0.04218619,-0.07378509,0.016230224,0.0354919,0.07093222,0.06887892,0.0142614115,0.061350804,0.010081951,0.0059839287,-0.053536456,0.004093608,0.059318885,0.015029494,0.04085328,-0.0058845626,0.01955328,-0.03887493,-0.07051507,0.049958374,-0.028666303,0.01453258,0.042609464,0.05990163,0.012385646,0.057828702,0.03226974,-0.010623112,0.054558504,0.055129543,-0.043667346,-0.056476936,-0.0469841,0.042640515,-0.03537808,-0.022865348,0.12310736,0.00413134,0.03208562,0.028299108,0.024368566,-0.0474576,-0.0046932753,0.008255307,-0.03957198,-0.029589657,-0.001552229,0.01657156,-0.03760278,-0.035694204,-0.0103051895,-0.016333645,-0.031088421,0.044922438,0.030270284,-0.13633525,-0.03580996,-0.009159693,-0.040223334,-1.2254625e-33,0.011729396,-0.050886165,-0.014363971,-0.0066374363,-0.07488661,0.11253054,0.06749725,-0.0479176,0.055796504,0.025188353,0.10229691,-0.029408332,-0.0013871078,-0.064543724,-0.052195534,0.05481254,-0.018672397,0.0019280735,0.008017857,0.012889599,-0.060467567,0.10610636,0.07041464,0.01906196,0.043433428,0.008354984,0.05610935,-0.000118320044,0.033293385,-0.019852536,-0.039680354,-0.060040623,-0.011909151,-0.096982874,-0.052675508,0.038560037,-0.03008465,-0.067654446,-0.0054794196,-0.0103043625,0.027804077,-0.035267644,-0.010040201,0.02032635,0.023775049,0.007980739,0.010952256,-0.03927983,-0.03804269,-0.04709417,0.055523697,0.014750513,-0.012070362,0.04059598,0.0049781576,0.031216336,0.056248475,-0.0063703526,0.0075532584,-0.0150292115,-0.008148872,0.036711924,-0.018332342,0.04829855,0.039715514,0.09957934,-0.0023229024,0.042336736,0.020145128,-0.034515113,0.061836623,0.00913854,0.03163412,0.12072063,0.015044708,-0.008624105,-0.007325467,-0.020482011,0.04681224,-0.051954236,-0.039673556,-0.0058859023,-0.08049638,-0.056910418,-0.075101696,-0.08795903,0.047392577,0.102202594,0.048004735,0.013612068,-0.003355575,-0.017181573,-0.041272115,-0.025052676,0.09513508,-2.3623045e-08,0.039898533,-0.07965436,0.0064161406,-0.04373491,0.030959709,0.011059224,0.043202687,-0.012219836,-0.0606966,0.05134816,-0.025228372,0.09929234,-0.011018097,0.01466568,0.019780353,-0.012855195,-0.021353615,-0.013164634,-0.013611301,-0.08792176,-0.05857329,0.09946372,-0.068041265,-0.04763399,0.04424524,-0.099696286,-0.03795015,0.09066386,-0.038096726,-0.011765671,0.033115055,0.00033469353,0.0059183193,-0.077416115,-0.025857905,0.08210511,-0.05981937,0.019302707,0.055269998,0.09005007,-0.014452367,-0.101067774,0.011504979,-0.021307409,-0.028371558,0.0410495,0.03953927,0.0030115054,0.08216901,-0.039084226,0.07458046,0.047194596,-0.011763497,-0.103102386,-0.084345736,-0.018715193,-0.005485111,-0.11657761,0.059423387,-0.083120786,-0.011238223,-0.058476802,0.08306861,0.00262321 +6.3.2.37,"Involved in the synthesis of cell-wall peptidoglycan. The D-lysine is attached to the peptide chain at the N6 position. The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase.",384,1.0,-0.044691574,-0.014061058,-0.09611043,-0.026111059,0.016701957,0.060281634,-0.104773074,0.04872294,0.04105011,0.036604002,0.0006238632,0.016790887,0.037798848,0.0011906156,-0.03134523,0.0050884197,-0.09191193,-0.039429817,-0.027105568,-0.026934737,0.029092116,0.04168963,-0.03695247,-0.028636377,0.04152852,-0.017279321,0.03614118,0.017399196,0.003025757,-0.07106425,0.0090395,-0.06843723,0.0071417,-0.021268725,0.04069225,0.015327987,-0.03549616,0.0073110512,0.08972531,0.03700592,0.033750758,0.017143335,-0.020113658,-0.05079715,0.054050684,-0.022073342,-0.087374374,0.032735925,0.03750194,-0.037771575,0.011981148,-0.044877023,-0.018827612,0.025468701,-0.0063044853,0.018385107,-0.08492451,0.049993016,0.09573872,0.013532581,0.04256704,0.092429906,0.040131144,-0.022199279,-0.009115941,-0.1796364,-0.0055238716,-0.025121802,0.072867334,-0.0028828247,0.004134363,-0.08004179,0.010299164,0.00055623305,0.08951003,-0.00023928366,-0.0028344232,-0.025146605,0.028369617,-0.030379128,0.01527503,-0.05431343,0.0488016,0.09363645,-0.040677812,-0.021647349,0.031514335,0.0099176075,0.02638752,-0.020461095,0.086594656,-0.08957236,-0.034494407,0.015134591,-0.07180227,-0.03453224,-0.0010340975,-0.00049464084,0.054915193,-0.0030314804,-0.0038307435,0.016655883,-0.06300958,-0.069724604,-0.013882898,0.033032212,0.022794645,0.08132471,0.033812337,-0.06838295,0.013339688,-0.039046906,0.020917984,0.02693818,-0.025436712,0.05800414,-0.032066736,-0.0733754,0.029104173,-0.059996802,0.07681629,0.047797453,0.010621129,0.11607948,-0.06480174,0.07510811,-0.05924783,-3.2083516e-34,0.0701367,-0.004910535,-0.006452803,0.008231349,-0.026468044,-0.022049807,-0.031039057,-0.04108292,0.0018856294,-0.0613113,-0.05303694,-0.02778315,0.0058262977,0.08909817,-0.07038158,0.023612866,0.010607331,-0.03715246,0.0058335853,0.059340212,0.0040530846,0.041725956,0.010302615,-0.0058477954,0.08327619,0.09695887,0.029754689,0.007482715,0.081834465,0.009922993,-0.096735224,-0.092799306,-0.0699905,0.043302577,0.01921545,0.044942405,-0.0075868843,-0.04178012,0.036502436,0.034863535,0.04997751,0.019405209,-0.039971642,-0.009237725,0.037249785,0.06971562,-0.08109998,0.06802431,-0.03763768,0.02049301,0.05387066,-0.038539097,0.08292132,-0.004820909,-0.061808087,0.0057130307,-0.049492028,-0.041732326,0.06536839,0.08450718,0.05051032,0.052099917,-0.009721929,0.054275542,0.028722601,-0.0055168835,-0.0079976125,0.00010956872,-0.03623877,-0.019742811,-0.13470832,-0.0065062908,0.13722208,0.010833634,0.00088972243,-0.05145469,-0.046438187,0.0154316295,-0.05081277,0.009237567,-0.019327397,0.05134771,-0.014388015,-0.008340764,0.01771983,-0.030052556,-0.023580972,-0.08053959,-0.038410876,0.12240733,-0.016460177,-0.04961258,0.004153729,0.11306229,-0.013423271,-1.241009e-33,0.070978984,-0.086979866,0.057247896,-0.05815301,-0.106182925,0.07637649,-0.0008288062,-0.025364866,0.0364125,-0.020125935,0.012535185,-0.018020958,-0.012869339,-0.061567776,0.027536083,0.0046856846,-0.0061482573,0.08361178,-0.055223174,0.009543972,-0.074793525,0.019226179,-0.043054894,0.044010293,0.030861795,0.016651327,0.006961579,0.013174635,0.058180828,-0.010244668,0.0013793742,-0.022990786,-0.04750681,-0.045341197,-0.06610846,0.107774995,0.006736113,-0.014188114,0.012812936,-0.040865213,0.02972065,0.04187176,-0.02357526,0.07688108,0.051208667,0.103604764,0.01419316,-0.019677605,-0.019497864,-0.0011954184,0.05075518,-0.078744195,0.02918927,0.019966617,-0.0034081212,0.018108292,0.03337874,0.05810483,0.019695746,0.03749204,0.034493778,-0.07829516,-0.023566568,-0.044326376,0.012785939,0.08925406,-0.014426166,0.04990146,0.07803227,-0.009240527,0.09203162,0.025711495,0.015017833,0.061121836,-0.000675661,0.03813148,-0.080573596,-0.10126761,0.021864064,-0.02468817,-0.045583576,0.019713826,-0.007282699,-0.047757383,0.06386251,-0.041300632,0.03765421,0.140701,-0.015912138,0.01592327,0.020882644,-0.083947435,0.003966633,0.031225096,0.055785593,-4.046342e-08,0.12221818,-0.10545284,-0.014176616,-0.07326433,-0.04732869,-0.0019468336,-0.028494496,0.011093496,-0.0018951715,-0.03695357,0.0031353922,0.04085666,-0.008260068,-0.045563865,-0.05092978,0.10137303,-0.011320452,0.0725694,-0.0014646853,0.026700968,-0.09073238,-0.0028557072,-0.09588545,0.029494068,0.014050619,-0.09591715,0.01760729,0.042026266,-0.014728134,-0.050906133,0.016734498,0.0015222403,-0.0971286,-0.05829254,-0.018942576,-0.005521679,-0.0010319061,-0.10066324,0.06870539,-0.022705091,0.055766582,0.0023506328,-0.049633738,-0.0162216,-0.022020113,-0.03800561,-0.022882033,-0.04889411,-0.05448654,0.007855139,-0.0033210518,-0.0067646233,0.020166079,-0.10034433,-0.13379528,0.014106676,-0.04011249,-0.083196476,0.031038646,-0.07347067,-0.047421914,0.025889412,0.1704491,0.01738064 +4.2.3.75,In Solidago canadensis the biosynthesis results in the pro-R hydrogen at C-1 of the farnesy diphosphate ending up at C-11 of the (-)-germacrene D [1]. With Streptomyces coelicolor the pro-S hydrogen at C-1 ends up at C-11 of the (-)-germacrene D [2].,384,1.0,-0.058211494,0.017163284,-0.15310259,-0.061362565,0.023834022,0.06499336,-0.033858955,0.08735113,0.036321755,-0.026009224,0.0023775562,-0.06080479,-0.05283858,0.023567006,-0.0554765,-0.09590055,-0.010752216,-0.034723263,0.067014344,0.008812001,0.07780706,0.026861956,0.068189286,0.01361692,0.092555664,-0.013591018,0.04627428,0.030216431,-0.02228068,-0.081503846,0.03463245,-0.03246375,0.061117154,-0.06903713,0.122166745,0.035098445,-0.04055274,-0.03788774,0.13370301,0.041452836,0.0024796347,0.0019040981,0.010241317,0.068453506,-0.10029146,-0.02643572,0.009279022,0.072217226,-0.013966221,-0.06294613,0.0103954915,-0.039797712,-0.06686501,0.03462549,0.045020364,0.027389461,-0.022567997,-0.028203089,0.0057018404,-0.07092398,0.024226945,-0.056495834,0.040900026,-0.053355746,-0.04949227,-0.0522747,-0.011334144,-0.027682219,0.047419585,-0.023386125,-0.05601567,0.018422384,-0.03674776,0.00893365,-0.0015757032,0.050421946,-0.006628735,0.003613548,-0.06452588,-0.038689572,0.050647102,0.04415079,-0.027173417,0.06435107,0.019340312,-0.02696433,-0.010574435,0.037900954,0.056876924,0.018677734,0.038829617,-0.06391337,0.035221763,-0.07322545,-0.13551034,0.031057013,0.019055609,-0.040373098,0.045083027,-0.049077053,0.018306952,-0.0027034648,0.018439962,-0.06008696,0.021524433,0.03485991,-0.07704485,0.10813486,0.08469524,-0.023871116,0.012519531,-0.03733273,0.016207831,0.0128046945,-0.07889978,0.01008408,0.008591621,-0.04238244,-0.0326756,-0.04209817,-0.03899368,-0.008207253,-0.043293897,0.034257658,0.0024380607,0.06598754,-0.12164518,3.839864e-33,0.09847337,0.00939769,0.05737989,0.003639344,-0.04350111,-0.0065947887,-0.10612263,-0.002060274,-0.004850785,-0.039989118,-0.14420882,-0.13181193,0.018843584,-0.06240989,-0.041449476,0.013436756,-0.033074763,0.01422181,0.010115972,-0.007264465,-0.07823853,0.08587779,-0.049512967,0.0049731308,0.057946958,0.039808534,-0.014328252,0.0076481877,0.07180705,-0.028553804,0.036637563,-0.034407254,-0.06072,0.09307519,0.07881944,-0.050004095,0.021525998,-0.050568637,0.034798197,-0.018884359,0.013514393,0.0780711,-0.009622782,0.011913349,0.117688216,-0.044196036,0.02217649,0.09398026,0.06513862,0.08736951,-0.005662305,0.018828738,0.0939244,0.035988327,-0.08966246,0.010530465,-0.011878843,0.06097723,0.090182416,0.05865081,-0.008723134,0.09393394,0.016929334,-0.029386513,0.0117456205,0.039567485,-0.13444212,0.003854939,0.008120696,0.109396145,-0.043774564,-0.046286438,0.049424034,0.007502341,-0.027274566,0.039902773,-0.042824734,-0.066291116,0.029283345,0.023915006,-0.012908377,0.0403471,-0.080002666,-0.062865436,-0.054390233,0.03320595,-0.06797482,-0.13778466,-0.006091146,0.11679315,0.006262193,-0.050771873,-0.049143933,0.025496075,-0.033876665,-4.686744e-33,0.05080313,-0.08323518,-0.028424837,-0.04485731,-0.045959737,0.049174864,-0.060971398,-0.03427159,-0.07201095,-0.05993136,0.038810503,0.0148698175,-0.0032139611,-0.03297066,-0.011618145,0.00079312705,0.0036816606,0.15391749,-0.02232064,0.04857813,-0.018550172,0.012607227,-0.0039715255,-0.017908588,0.014390204,0.040899374,0.038065627,0.055835824,0.016046925,0.040361255,0.08606861,-0.017339507,-0.07421008,-0.038046822,-0.06336329,0.014827133,-0.030502051,0.04188057,0.06748217,0.028471101,-0.0037604964,-0.032986294,0.06354185,0.09723407,0.08643677,-0.012551689,-0.04087021,-0.017492445,0.028805368,-0.016498229,-0.06629102,-0.048352674,-0.006809172,-0.005283067,0.010076892,-0.02633133,0.07386324,0.039585426,-0.010692396,-0.06434718,-0.026636017,0.015718974,0.04888638,0.013262579,0.039370142,0.028861504,-0.010781351,0.03747751,0.07509328,0.014592665,0.050986055,0.027433593,-0.018973539,-0.029467292,-0.035585474,0.034785405,-0.0360418,-0.05697664,0.020641603,0.016627437,-0.038285166,0.005668292,-0.0061547863,-0.05801237,-0.017967379,-0.02572648,0.04184432,0.038046665,-0.0040681963,0.106480725,-0.024251707,0.052979495,-0.013546541,0.024950387,0.06619394,-4.1076145e-08,0.0644159,-0.014816468,0.040229686,0.010226108,0.038099613,-0.022195578,-0.01976609,-0.05082085,0.025903689,-0.008435395,-0.04635242,0.0053078784,0.034043435,-0.06898878,0.09367763,0.0044860714,-0.027445138,0.015328033,-0.05827245,0.013593762,-0.087373115,-0.013502498,-0.07144445,0.021836558,-0.046170328,-0.088936955,0.0517918,0.007942381,0.0030533494,-0.009288408,0.051135417,0.0075284643,-0.029641647,-0.003550297,0.026523095,-0.05955567,-0.03308224,0.042938598,0.037541877,0.014259925,0.012854923,-0.028185545,-0.089010835,0.052652486,-0.06887921,0.043851055,0.007180275,0.06303636,-0.117736466,0.008260213,0.029982306,-0.0026895348,-0.075819574,-0.0143074915,-0.061099507,0.029942509,0.00021856488,0.014329462,-0.07073157,0.020293174,-0.022356814,0.02243681,0.08812182,-0.016110439 +4.2.3.76,Initial cyclization gives germacrene C in an enzyme bound form which is not released to the medium.,384,1.0,-0.024589857,0.008626829,-0.044618484,0.028976297,0.031822227,-0.0065180217,-0.015491844,0.089031406,0.011191251,-0.007125607,0.046793617,0.011496199,-0.004859693,0.09785933,-0.08595853,-0.055938542,-0.032942224,-0.01118334,-0.014933621,-0.0009440983,0.035022397,-0.010304628,-0.003627494,0.04018684,0.07306001,-0.061201476,0.000915643,-0.039982416,0.011387318,-0.0033372904,-0.05187807,0.008749337,0.013561677,0.03917483,0.025395293,0.10549915,-0.082681134,-0.006179039,0.018844243,0.009332509,0.02349183,-0.0037743438,-0.042140983,0.07536498,-0.0040481333,0.008526782,0.040263798,0.00699106,-0.07045185,-0.010501949,-0.04851184,-0.05016782,-0.05671493,0.02089294,0.006092069,0.02595358,-0.08099163,-0.003154916,0.014768772,-0.0044860947,-0.04158085,0.020218592,-0.04500067,-0.027740283,0.08861615,-0.039494734,0.06262971,-0.039781034,-0.03304698,0.032648418,-0.011715947,-0.03426256,-0.025054475,0.019013504,0.041554783,0.014239279,-0.040895436,0.025398849,-0.05506923,0.055969387,0.04000403,-0.0003981492,-0.03807678,0.06273258,0.010305638,0.02187203,0.03766723,-0.017586105,-0.0035016297,-0.007941523,0.03893933,0.039879054,-0.07849376,-0.031175148,-0.0017146438,-0.06902664,0.08704558,-0.06793718,0.008299831,-0.01841491,0.04617866,0.047768895,0.001246113,0.031390414,-0.0036012563,-0.040945895,0.024480654,0.043197017,-0.048874296,0.055104025,0.038579907,0.033449862,0.07370434,-0.00472752,-0.015605994,0.15658943,0.018495534,0.022687027,-0.027754206,0.018691288,-0.00556859,0.009168813,-0.010761063,0.070816785,-0.081008725,0.038912363,-0.009080148,6.926386e-34,0.020857148,-0.06398606,0.042991158,0.078108385,-0.08277789,0.017248362,-0.032442972,-0.026288208,-0.02187322,-0.04304565,-0.05368876,-0.05701439,0.017570237,0.034911204,-0.053578023,0.04203221,0.024838198,0.004301913,-0.011860105,-0.01559673,0.012593984,0.009061184,-0.051630434,-0.033637483,0.008714384,0.0211606,-0.03383987,0.011553575,0.052049216,-0.006409502,-0.0427277,-0.014483937,-0.02937879,0.04559888,0.0476062,0.058985446,-0.011126935,-0.031249257,0.04551873,0.01185332,-0.04427021,0.014930903,0.028786728,-0.06700935,0.07146237,-0.058988117,-0.103613526,0.11348712,-0.059246756,0.023177188,0.08467862,-0.018980905,-0.035474602,-0.0032052782,-0.034328833,0.04847398,0.0038705817,-0.025576808,-0.028416622,0.016627505,0.028153876,0.06123119,-0.048900444,-0.007995042,0.013307865,0.07957961,-0.17404082,-0.035153206,-0.052122436,0.09610199,-0.06949255,-0.041984998,0.04671142,0.081623614,0.026461076,0.056898613,-0.08808415,-0.03212172,0.080664545,-0.019208632,-0.020390447,-0.034502644,-0.039171066,-0.027857697,-0.053320378,-0.04789675,0.013589514,-0.07987516,-0.05397344,0.06770857,0.012507463,-0.039904468,-0.0043775085,0.0069769304,-0.010221076,-2.899784e-33,0.072230466,-0.09632375,-0.052053206,-0.023508385,0.0040200683,0.051962573,-0.04616237,-0.14298667,-0.037760545,-0.04492939,0.068705626,0.0026399912,-0.06366079,0.0010551495,-0.01684421,-0.051181037,-0.019786963,0.10549093,0.038368158,0.115129575,-0.077130415,-0.0449898,-0.015043258,-0.0050738244,0.03041387,0.0124665825,-0.080711424,0.122938745,0.024463955,0.05068265,-0.07416849,-0.019785687,-0.061236918,-0.053983822,-0.0014553014,0.060532313,-0.050703462,-0.058835875,0.03908418,0.030026449,-0.05269016,-0.04544944,0.013733006,0.03077244,0.08143283,0.06284907,0.06254336,-0.03044655,0.05635113,-0.009952366,0.059043765,-0.016648334,0.046642356,0.032472517,-0.0021048414,0.10401568,0.10186298,0.007874645,0.035131898,-0.06929983,0.00759472,0.016133655,-0.03934436,-0.08819889,0.0023629987,-0.008902832,-0.015163857,0.1814428,-0.008606094,-0.053859547,0.06529945,0.033012077,0.07407157,-0.0703968,-0.06779666,0.035187155,-0.053934034,-0.04369082,-0.013173638,-0.10764628,-0.017906012,0.112841696,-0.029783625,-0.06466655,0.042365495,-0.08243746,0.06852064,-0.0625956,-0.004887645,0.018547159,-0.0051301997,0.0074274084,0.041370027,0.07029777,0.087835446,-2.6073693e-08,0.046563677,0.017745297,-0.0276338,-0.019684484,0.020904023,-0.013310999,0.0064376546,-0.042363297,-0.0033277126,0.0011813442,-0.07827863,0.1005346,-0.0023981954,-0.0028086272,0.06220075,0.026290344,-0.096760415,-0.05723033,-0.04506772,-0.042087294,-0.10174445,-0.021791475,-0.10200943,-0.03657187,-0.027209705,-0.12683098,0.07592557,0.043971326,0.00043035045,0.014335555,0.039708074,0.019510724,0.0720321,0.067542486,-0.07052943,0.023844253,-0.030695919,0.017670877,0.0076147285,-0.060384784,-0.018486205,-0.009511604,-0.0932452,-0.006484137,0.0066244793,0.005717582,0.019098349,0.034829352,-0.026063481,0.10462421,0.045823004,0.032402705,0.0109186405,-0.01428026,0.06983471,-0.007029027,-0.002600666,-0.0057815732,0.008231442,-0.06495212,-0.10437785,0.025652455,0.17064516,0.020945353 +4.2.3.77,"Requires Mg2+, Mn2+, Ni2+ or Co2+. The formation of (+)-germacrene D involves a 1,2-hydride shift whereas for (-)-germacrene D there is a 1,3-hydride shift (see EC 4.2.3.75).",384,0.99999994,-0.072275616,-0.043060604,-0.002187576,-0.01651426,0.046425242,-0.0760515,0.020952458,0.0009307276,0.03104713,0.021785429,0.04184311,-0.0121251475,0.051194407,-0.002150501,0.032577295,-0.059233602,-0.047583573,0.034600604,0.0280595,0.024574354,0.08857661,0.004656235,0.0055556926,0.00045482416,0.12574217,0.049882498,0.07229967,-0.0039340616,0.041214462,0.021970272,-0.008761717,0.0274175,0.02260899,-0.054669585,-0.034868516,0.04528322,-0.026054151,0.06017259,-0.029415878,0.07297616,-0.029154165,-0.0055076345,0.12523016,-0.019919954,-0.050128974,-0.048823606,-0.03643449,-0.00891275,0.0069298977,0.009019788,0.004728143,0.019344248,-0.105030924,0.02393268,0.029541632,0.02405807,-0.102121636,0.029071553,0.036379892,-0.041818045,-0.0072781206,0.0012851777,0.01574256,-0.066545054,0.07068221,0.0011143824,0.011188812,-0.10444165,0.028869728,0.0040619164,0.0074901627,-0.018689442,-0.03999603,-0.038953368,-0.016502889,-0.0067374054,0.040296678,-0.009650725,0.049287792,-0.037962314,0.019716073,0.10158524,0.069998525,0.0704953,0.03673337,0.06338136,-0.009082316,0.05208791,-0.026013255,0.0100130495,0.070160784,0.028944695,-0.03918146,0.0009991847,-0.06952009,0.021225922,-0.03519445,0.039678592,0.036921795,0.004637814,0.01862407,0.03144015,-0.13144092,0.0032771335,-0.027821371,0.0061260373,0.024222411,0.02391146,-0.05407425,0.05568787,0.052037027,0.031853635,0.054908127,0.032012325,-0.065927096,0.05240689,-0.0041047535,-0.019095073,-0.04318823,-0.029475253,0.008451436,0.022877052,-0.0015474145,0.07039395,-0.012305856,0.068508916,-0.017749807,2.4263992e-33,0.034044687,-0.02094416,0.050825216,0.08646639,-0.11142264,0.07866925,-0.1194245,-0.0008299159,-0.006977162,-0.053366367,-0.0933349,-0.05299625,0.010731923,0.06498178,-0.06413735,-0.009379927,0.05165846,-0.04539449,0.05157082,-0.01804,0.0014763217,0.072682545,-0.0013375294,0.046248928,-0.01705849,0.09870867,0.050442744,-0.012826098,0.054996878,-0.006906681,-0.029385397,-0.08581889,-0.0031238245,0.025930533,-0.004886729,0.07070246,-0.04792302,-0.034516837,0.006826631,-0.042321034,-0.08735969,0.06415757,-0.08246125,-0.0068178703,0.027905246,0.0241119,0.020240203,0.09946126,-0.00025328455,0.084745675,0.017679669,0.046077173,-0.07147002,-0.0049409647,-0.096065655,0.027700957,0.0028352656,0.044928987,0.09230574,0.030802183,-0.04338584,0.030832684,0.053963527,0.026926666,0.042513482,0.069199584,-0.10482985,-0.06818043,-0.025595684,0.059718747,0.0066036903,-0.07686935,0.024182057,0.10408406,-0.00393923,-0.030175941,-0.02728215,-0.09810633,0.06264706,-0.009505678,-0.06272479,0.055850293,-0.014795321,-0.043308396,-0.082432926,-0.06982478,-0.06246784,-0.08820407,0.0069701937,0.039641436,-0.05671077,-0.006706122,0.009386165,0.010801342,0.03242661,-4.1266163e-33,-0.047120675,0.011429637,-0.018024817,-0.05324295,-0.04564413,0.07495997,0.059037436,-0.18475533,0.048664138,-0.023384178,0.10639864,-0.027697107,-0.11141016,-0.013900077,-0.031953033,-0.046395075,-0.03387814,0.008402672,0.032723688,0.015888121,-0.040823456,0.0894733,-0.06644729,0.010814935,0.033403974,0.057775367,-0.0069339504,0.047155883,0.03406664,0.052877326,0.0040003583,0.07313676,-0.02885876,0.048707154,-0.059447892,0.09646,-0.067343704,0.023836017,-0.0583563,-0.00077191717,-0.11198397,-0.048439115,0.12046451,0.059842136,0.05048292,0.012726103,0.018550169,0.004444005,0.033027843,-0.031439073,-0.018585606,-0.026815686,-0.055829886,-0.04458986,0.008415273,0.016965538,0.0205717,0.02716145,0.060155377,-0.030059377,-0.01934081,-0.009461345,0.081283025,-0.13302298,-0.05007849,-0.008145611,0.06479214,-0.004073405,0.07127769,-0.06604732,0.071989484,0.04116821,0.12751687,-0.039617293,-0.060183775,-0.06053185,0.030534914,0.019694403,0.024449032,-0.0787541,-0.017456237,0.05521806,-0.0033797363,0.04376003,-0.119443595,0.0010427214,0.01431652,0.042101115,-0.0011790353,0.065013774,-0.038666636,0.036387794,0.010995766,0.027802002,0.080811545,-4.4557712e-08,-0.03540979,-0.039109755,0.008490807,-0.053529464,0.02027302,0.028762134,-0.02347311,-0.009507415,0.017003762,-0.059029616,-0.006874658,0.021698704,-0.020953678,-0.052170254,0.030473035,-0.044958998,-0.037968885,-0.0069280383,-0.08530103,-0.016869614,-0.07519628,-0.071932875,-0.1368579,-0.03299572,-0.051116183,-0.09659639,0.030162737,0.0016821349,0.0031935629,-0.023302948,0.049174353,0.0006255456,0.0052143116,0.016261883,-0.011383317,0.007463155,-0.014078591,0.042448852,0.042380657,-0.059630137,-0.06596741,-0.037312593,0.0061676195,-0.005274194,-0.07877602,-0.028949125,-0.027226832,-0.00077007886,-0.09137026,0.084634185,0.021091854,-0.07006584,0.0076123998,-0.054519217,0.012348765,0.030627262,-0.01759495,-0.07956226,-1.4614523e-05,-0.084311984,-0.01341771,-0.060221273,0.028835006,0.0130585665 +1.3.5.6,This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. ,384,0.99999994,-0.09671909,0.03165451,-0.12274247,0.0022994694,0.029040823,0.056510504,-0.067944355,0.054261137,0.0036788904,-0.008998925,0.029531877,-0.08641709,-0.06983524,-0.014009288,-0.039779294,0.086929634,-0.08029375,0.037326545,-0.019360993,-0.031529218,0.08211532,0.04024864,-0.058114618,0.030300975,0.05245317,-0.0027513155,-0.009512363,-0.032570414,-0.0388214,0.026717586,-0.08018118,-0.04143926,0.10293515,-0.059209153,0.07977176,0.06351152,-0.035637107,-0.06299601,0.0012569715,0.025545478,0.049394898,-0.011492922,-0.023043359,0.009534229,0.0154330535,0.03429641,-0.0021152378,0.0799164,0.03282052,-0.034801923,-0.07517315,-0.009952015,-0.037340213,-0.058626644,0.0005319293,0.04236748,-0.025349502,-0.019093702,0.031476606,0.029039718,0.10619016,-0.013485235,-0.00026716763,0.021782564,0.06624603,-0.05782442,-0.043079637,-0.05494371,0.022846967,-0.12420386,-0.025073249,-0.092860445,-0.017404426,-0.02029396,-0.028233912,-0.0086190235,0.007997535,-0.008193705,-0.022498235,-0.0047203163,0.08337985,0.009733193,0.0014005284,0.023198433,0.030069344,-0.015889367,-0.012542498,0.074227266,-0.0115303695,0.05548166,0.016947418,-0.025192939,-0.011301101,-0.012189086,-0.08230721,0.039278526,0.087319165,-0.091254726,0.036783725,-0.06203114,-0.003518327,0.08280535,0.025091957,-0.083263144,-0.02423693,-0.0023641994,0.0062781563,0.07812432,0.002430974,0.014635849,0.010573823,0.05588885,-0.013550989,-0.033981632,-0.024223013,0.084543064,-0.042098496,-0.041693576,-0.053443413,0.10388942,0.0009429348,-0.022881886,-0.0051325657,0.06374365,0.013657218,0.051411215,-0.10291974,5.7138457e-34,0.066156,0.03852376,-0.02394834,-0.02408527,0.04917457,-0.04937867,-0.03296589,-0.072950915,-0.04277645,-0.090336084,-0.11944426,-0.08457934,0.06947945,-0.014121357,-0.054941352,0.040802892,-0.079859786,-0.0042444984,0.056567818,0.038199622,0.015999107,0.035014648,-0.072856866,0.03489483,-0.009888651,0.043642838,-0.028998813,0.007104694,0.042308524,-0.016500233,0.007470032,-0.059982378,-0.066382036,-0.058212023,0.17192306,-0.04067379,-0.012736944,-0.080086015,-0.061060894,0.08674436,-0.05759623,0.0344442,0.017421247,0.024175702,0.0005226522,-0.0336331,-0.013623923,0.016276442,0.08723309,0.088884436,0.049284425,-0.028264955,0.08174072,0.00062320457,-0.025841014,0.047234062,-0.018452821,0.00042279958,-0.0062450655,-0.00577734,-0.0313151,0.054623216,-0.025972383,0.010391848,-0.001203863,0.018185785,-0.06640753,-0.038154487,0.034734413,0.05576115,-0.05238399,-0.07845744,0.015474198,0.028311512,0.061446033,-0.0026976212,0.014474779,-0.005594648,-0.0083799865,-0.014917196,-0.01578569,-0.005375485,0.06274572,-0.08112097,0.007913229,0.008803331,-0.05299488,-0.061928216,0.0015477194,0.005889545,0.03193145,-0.04945782,-0.03344867,-0.03028735,0.0032860427,-2.3127943e-33,0.08102142,-0.11145753,0.047064,-0.0068764333,-0.007246654,0.0337112,-0.12190203,-0.08651622,0.022480944,0.034824245,0.027196122,0.029536108,0.07572256,0.030668646,0.016640218,0.05220403,0.050638974,0.08904716,-0.05860041,0.007190237,-0.028752416,0.038091004,0.027051073,-0.0062063253,0.027058009,-0.013677667,-0.07067051,0.030962475,0.05314763,-0.015035649,0.014032115,-0.017522,-0.089609705,-0.021397278,0.017048473,0.062387295,-0.07154718,-0.007804042,0.04534933,0.08709745,-0.022286337,-0.004594394,0.0164303,0.045862764,-0.01572009,0.0050342525,-0.05942199,0.0272279,-0.04865701,-0.012912762,0.041489746,0.014296691,0.0060945237,0.055373315,0.040901795,0.007060991,0.13000429,0.07647408,-0.04322295,0.015431405,0.02986672,-0.13488208,0.03150523,-0.074977726,0.0663219,0.08132639,0.023941485,0.095619306,0.040141962,0.009113819,0.0815505,0.045021676,0.06153701,0.05657385,-0.067934036,-0.026649259,-0.033255115,-0.062469613,-0.03126306,-0.036542755,0.053124223,0.018876893,0.054099586,-0.03668501,-0.09743076,-0.042380597,0.05932301,0.09502335,-0.025457138,0.014549985,-0.046417795,-0.013319131,-0.02177286,0.064523876,0.06478709,-2.1801856e-08,0.02263198,-0.011706962,0.02542813,-0.08195144,0.018753733,-0.0017087428,-0.012683644,-0.008612511,0.034357157,-0.031520084,0.003239146,0.021532668,0.040805243,-0.019850027,0.06262118,-0.02231501,0.057813905,0.01939176,-0.008399589,0.10365626,-0.074919365,-0.0003346038,-0.15206595,-0.011566663,0.02911927,-0.0953958,0.06920113,0.060714077,0.00795542,-0.028161002,0.02328497,-0.021864874,-0.006661944,-0.016763706,-0.11821069,0.07095836,0.0016814303,-0.04764462,-0.053388532,-0.01938114,-0.011173674,-0.02703088,-0.0412104,0.027005276,-0.09419433,-0.0030784544,0.019272562,0.021013826,-0.012121894,0.023409344,-0.04088508,-0.038403075,-0.00583541,-0.05420896,-0.047926802,0.012492927,0.052469812,-0.020564165,-0.001850457,-0.028539421,-0.04724342,0.06856322,0.17128244,-0.03189816 +1.3.99.26,This enzyme is involved in carotenoid biosynthesis. ,384,1.0,-0.058950808,0.022433562,-0.14108646,-0.0015015483,0.032562125,0.018715559,-0.0573474,0.057939827,0.014374397,-0.03699428,0.013488928,-0.06144799,-0.05809636,-0.011090988,-0.02921022,0.055392765,-0.06757533,0.0013949461,-0.0130167175,-0.08058563,0.079249665,0.012087104,-0.03611879,-0.0013567401,0.056821305,-0.0031084642,0.05628978,-0.07451318,-0.028053226,0.0113063445,-0.06659708,-0.059282284,0.08826799,-0.0637566,0.04112429,0.08596524,-0.054034825,-0.047737516,-0.030018732,0.018168049,0.033892106,-0.03360021,-0.03161744,-0.008814818,0.022582168,0.010706968,-0.04233165,0.09505792,0.022479208,0.015539736,-0.09348418,-0.040729914,-0.036467887,-0.08035342,0.011932263,0.049637303,-0.025258314,-0.031377174,0.010576719,0.027496794,0.096907236,-0.01659067,0.0071383016,0.013206141,0.09366651,-0.05696197,0.015102122,-0.06659422,-0.0056087193,-0.13233657,-0.013059981,-0.073856734,-0.0017775997,-0.03620211,-0.007789358,-0.03940508,-0.03249904,-0.009834772,0.007345413,-0.012078333,0.10677655,0.01751038,-0.0012641888,0.058586568,0.046502903,0.02244197,0.009320992,0.060511664,-0.00079931977,0.051207867,-0.020053433,-0.07077393,-0.037090894,0.0337643,-0.067889735,0.011076283,0.06385017,-0.082885325,0.0017465437,-0.06809268,-0.0015260702,0.090324454,0.00808285,-0.059794758,-0.05216336,-0.006528177,0.0033661409,0.099082395,-0.009537739,0.010075872,0.032488007,0.06719375,0.032250464,-0.016709149,-0.04903836,0.094841555,-0.053103276,-0.049414616,-0.0583673,0.09297251,0.026333172,0.03954374,-0.014749148,0.076645814,0.0010097012,0.0210335,-0.08750834,-4.7413133e-34,0.04389803,0.052954756,-0.022386843,-0.00671878,0.032277185,-0.0153311575,-0.051970642,-0.06369155,-0.054951884,-0.060204104,-0.09751941,-0.102995984,0.07191987,-0.0023504533,-0.021412581,-0.0059284233,-0.042901788,0.0037940165,0.043907102,0.021554941,-0.006119895,0.043426275,-0.08194052,0.037617836,-0.010516617,0.06477085,-0.05360116,0.032948956,0.037251387,0.0020288974,0.020714493,-0.04329595,-0.08092246,-0.048166703,0.14414133,-0.028382163,-0.022953235,-0.083591245,-0.07374715,0.0812473,-0.016030867,0.03187113,-0.00048627506,0.014428811,-0.0035287375,-0.08279701,0.01071293,0.05092105,0.09389412,0.095806174,0.040364407,-0.0070592533,0.1021704,-0.016414575,-0.031187212,0.058376268,-0.023275053,-0.022484364,-0.01300957,-0.01456343,-0.019642323,0.05339481,-0.03232094,0.02166926,-0.02396342,0.018180566,-0.052375104,-0.0636422,0.03216495,0.06455606,-0.028080603,-0.03657408,0.031150965,0.045324545,0.027548391,-0.008744368,0.011233707,0.008246269,-0.006263435,-0.04396488,-0.01659328,0.02874837,0.058524106,-0.07494963,-0.0021540802,0.0337524,-0.0373237,-0.061669443,-0.012326054,0.03483709,-0.007126451,-0.063059166,-0.055479724,-0.03307103,0.03865046,-1.0222997e-33,0.08694784,-0.12316461,0.047894474,-0.028680772,-0.0070073744,0.0351521,-0.076312646,-0.088054225,0.028350532,0.040711373,0.009775792,0.028157327,0.06031316,-0.01619751,0.048354182,0.08876256,0.027687352,0.07457939,-0.037587404,-0.006024009,-0.017617872,0.06889603,0.0265499,0.03546965,0.030665256,0.02258994,-0.058549415,0.032977797,0.067802124,0.0060732714,0.019736314,-0.062542245,-0.08825369,-0.006603842,0.013753257,0.08544567,-0.052385096,0.022874339,0.028333984,0.063566506,-0.07095213,0.021731257,0.031124594,0.047575362,-0.0079226345,0.027967634,-0.03642105,0.03260445,-0.031716906,-0.06054835,0.034802668,0.012959705,0.011801802,0.052033823,0.04977027,0.0014294392,0.11118793,0.062668085,-0.043387737,-0.013632104,0.02043009,-0.09012921,0.039067723,-0.08108584,0.0729789,0.042892877,0.0055447617,0.0699962,0.07169384,-0.006692846,0.09590562,0.04747136,0.039695717,0.057395443,-0.045355022,-0.051248252,-0.08181338,-0.028457059,0.008847438,-0.05701517,0.032528218,0.024041291,0.04730829,-0.041998614,-0.092125006,-0.048423424,0.050922144,0.10533231,0.010131547,0.032216854,-0.048639607,-0.018394427,-0.046859883,0.04419182,0.070754595,-1.898587e-08,0.051864695,-0.041024923,0.0057550804,-0.089197524,0.013208404,-0.017113386,-0.024154844,-0.008044712,0.031905934,-0.025057519,-0.02994226,0.031432103,0.043215115,0.01106458,0.030318424,-0.023829903,0.060200796,0.03362944,-0.025602274,0.08144803,-0.07624027,-0.0011395433,-0.13061067,-0.01866079,0.048747193,-0.09435719,0.06310035,0.04354176,0.010662798,-0.0136933755,-0.00097340444,-0.0033797706,0.0014698751,-0.054569826,-0.125961,0.07923457,0.022513725,-0.010780962,-0.03982063,0.005643332,0.0075657293,-0.05023046,-0.01233866,0.035137244,-0.08249993,-0.002738326,0.018931583,-0.013284471,-0.0153589295,0.030393556,-0.048591986,-0.030180894,-0.01928048,-0.014656351,-0.07403258,0.00089109805,0.033866305,-0.040415704,0.047755454,-0.038550574,-0.025893461,0.09012792,0.20533904,-0.039782263 +1.3.99.27,"The enzymes from Rubrivivax gelatinosus and Rhodobacter sphaeroides prefer the acyclic carotenoids (e.g. 1-hydroxy-1,2-dihydroneurosporene, 1-hydroxy-1,2-dihydrolycopene) as substrates. The conversion rate for the 3,4-desaturation of the monocyclic 1'-hydroxy-1',2'-dihydro-gamma-carotene is lower [2,3]. The enzyme from the marine bacterium strain P99-3 shows high activity with the monocyclic carotenoid 1'-hydroxy-1',2'-dihydro-gamma-carotene [1]. The enzyme from Rhodobacter sphaeroides utilizes molecular oxygen as the electron acceptor in vitro [3]. However, oxygen is unlikely to be the natural electron acceptor under anaerobic conditions.",384,0.99999994,-0.11398324,-0.046876658,-0.09233686,-0.025660776,0.021520052,0.004948452,-0.06553991,0.048889596,-0.03767253,0.0113296,-0.01541157,-0.06768709,0.024003867,0.08268516,0.0059535555,0.05608269,-0.031757433,-0.01629641,0.031039111,0.056857742,0.09579935,-0.015145346,-0.07170801,-0.0014378449,0.05424779,-0.03383639,0.024650302,-0.043641157,-0.11118536,-0.009914059,-0.0300929,-0.0076697725,0.05163427,-0.06060934,0.05768131,0.08624043,-0.05682399,-0.062710695,0.04174648,0.081373364,0.014869762,0.03351556,-0.0038147941,-0.0032000002,-0.055923093,-0.023024937,0.046221036,0.038058724,0.039627995,-0.036609713,-0.06734638,-0.01833014,-0.053204883,-0.01585517,-0.0067142867,-0.019092312,-0.079724975,-0.007799125,0.006924192,-0.030298462,0.053979367,-0.030670213,0.036463987,0.01075189,-0.021400413,-0.07559462,0.02243797,-0.10308247,-0.023751013,-0.028763961,-0.054320138,-0.019261329,-0.00016357716,-0.033655114,-0.049231783,0.04439678,0.04812469,0.00054494827,-0.003401647,-0.07120423,0.0068982616,-0.024645858,-0.025870612,0.07600337,0.04792291,0.0039377436,0.038415175,0.07363515,-0.010871788,0.11615512,0.02263922,0.043377373,0.036637705,-0.052804817,-0.039747756,0.02625845,0.037173856,0.016515465,0.04816851,-0.04875794,0.006213785,0.096603595,0.012260629,-0.08617464,-0.014394345,-0.021691253,0.0063462174,0.115894206,0.005001859,0.03408888,0.029931637,0.049634404,-0.0016664474,-0.051308002,-0.040821332,0.12845777,0.02061998,-0.06890681,-0.12763771,0.037523646,-0.040124666,-0.04017114,0.05987206,0.013834482,0.026679697,0.082107306,-0.077139474,3.937828e-33,0.026472505,0.0122685,-0.021468459,-0.034171775,-0.054374058,0.03673796,-0.114412375,0.042287253,-0.026507303,-0.0708344,-0.12470485,0.0077889906,0.09878876,0.022719417,-0.077841245,-0.0016545287,-0.01793997,-0.00046832144,0.019740868,0.053994834,0.034550384,-0.0111199105,-0.04957291,0.04318446,0.03754022,0.010571616,0.0027864822,-0.037593618,0.03342736,-0.032131877,0.049192037,-0.13566552,-0.05641449,0.0023921437,0.09366141,-0.0014885485,-0.071410365,-0.020640558,-0.034348324,-0.0027138419,-0.01902124,0.02264285,-0.008307695,-0.017952358,0.033603925,0.008065834,-0.027901389,0.027770245,-0.0007103146,0.06337491,0.027487867,0.024073519,0.1094263,-0.00905439,-0.04139538,0.0050695916,0.043038625,0.038874757,0.007574759,-0.009948307,0.03206513,0.13651744,-0.0301417,0.0039462694,-0.025402054,0.04883522,-0.032984775,-0.021194652,0.015475028,0.0024151371,-0.065895185,-0.050773885,0.045886103,0.008203825,0.046222217,0.0013280525,0.0067909025,-0.0071909497,0.03226394,-0.042692646,0.0014691598,-0.02300571,0.09249538,-0.07760817,-0.030705782,-0.00352581,0.0020167166,-0.041182663,0.02711969,0.046136145,0.11494854,-0.10882886,-0.04176408,-0.07582549,0.0018096523,-3.7674014e-33,0.09131109,-0.094757006,0.022475908,-0.05334171,0.020638198,0.09263435,-0.03963491,-0.06411267,-0.0054672346,-0.10920904,0.064140655,0.057760444,0.0006930892,-0.03749532,0.04861112,-0.024002599,0.002601191,0.086866856,-0.0007815186,-0.020691775,-0.038772885,0.108574465,0.039118886,0.009010242,0.040204637,0.01920291,-0.022762677,0.036335837,0.10190782,0.021877535,-0.031504147,0.06163284,-0.029126748,0.02694347,-0.023303583,0.043325804,-0.114143744,0.022363983,0.05454124,0.08351179,-0.025769996,-0.013108634,-0.028308772,0.04584222,0.009825155,0.08846968,-0.08254635,0.008004842,-0.03067788,0.03174571,0.01239099,0.00907731,0.009675424,0.0115269,0.088890485,0.020067723,0.011924226,0.036134742,0.014077969,-0.035481654,-0.024016509,-0.10286779,0.03433812,0.019372862,-0.014321657,0.091090865,0.015735418,0.1228516,-0.026715487,-0.04228808,0.05844494,0.021317849,0.011530855,0.015856752,0.005554126,0.019613683,-0.038363937,-0.019409155,-0.022350492,-0.025834002,0.018870322,0.057633583,-0.0050618914,-0.011400752,0.010817423,-0.013588878,0.022743633,-0.016552981,-0.016667925,-0.004350783,-0.011212306,-0.024545902,-0.023154866,0.026470998,0.12742326,-5.0382717e-08,0.027951166,0.045966726,0.100059085,-0.018371794,0.04790273,-0.03666828,-0.01141004,0.008982212,0.042409074,-0.0070009613,0.038670037,0.017079156,0.046268683,-0.037006587,0.08542732,-0.0049911053,-0.04327152,-0.013125475,-0.017021867,0.100486465,-0.09029236,-0.041167323,-0.1852593,0.05108284,0.016059957,-0.051321052,0.025154732,-0.04117856,0.03556117,-0.035903063,0.031812422,0.016121702,-0.023352308,-0.016957816,-0.11832921,-0.040170085,-0.040526453,0.016293904,-0.040230162,0.05451287,-0.005571183,-0.07913419,-0.0914768,0.019712279,-0.054495264,0.021197487,-0.029752383,0.028694447,-0.021394093,0.0049497774,0.022841292,-0.0007400153,-0.04534511,-0.09324308,-0.115694,0.061613526,-0.00027920035,-0.020107722,-0.075904876,0.0016554935,-0.029243937,0.031790514,0.15020669,-0.01107699 +1.3.99.28,"This enzyme is involved in carotenoid biosynthesis and catalyses up to three desaturation steps (cf. EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)], EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)], EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]). The enzyme is activated by FAD. NAD+, NADP+ or ATP show no activating effect [1]. ",384,0.99999994,-0.07968158,0.000748467,-0.07085962,-0.026886204,0.0344091,0.037193924,-0.07642085,0.07364999,0.03532721,-0.017100682,-0.032324858,-0.0183565,-0.04975571,0.02291789,0.027559008,0.02688659,-0.063387334,0.016442768,-0.03135304,-0.055777945,0.13346392,-0.041416816,-0.029201215,-0.015970476,0.11058513,0.00069076946,0.054216962,-0.054118097,-0.004868726,-0.04209633,-0.060326263,-0.04371569,0.00039000472,0.001711468,-0.0077273496,0.05678227,-0.04450188,-0.024065487,-0.029634152,0.03617495,0.057412278,-0.010174134,-0.09281037,0.015077162,-0.0008414342,-0.019826675,-0.07549664,0.1493713,0.011091212,-0.01962659,-0.062432773,0.007593082,0.0067969193,-0.052428216,-0.022415563,-0.002512781,0.0024647012,0.02432256,0.02626771,-0.050210316,0.08121989,-0.072102964,0.013683072,-0.034136247,0.057797693,-0.03152948,-0.026370475,-0.1042166,0.071561195,-0.086462885,-0.06919623,-0.024122048,-0.025048567,0.02001191,0.018585382,0.016370518,-0.07383271,0.011959127,-0.037471887,-0.018557984,0.0998862,0.034445345,0.019598497,0.050798677,0.06741986,0.04043416,-0.027841514,0.035045017,0.007821469,0.027971644,0.00025817583,-0.04882575,-0.08380126,0.09001353,-0.11273132,0.059012946,0.018300949,-0.06898832,-0.041525852,-0.03910961,0.011349778,0.09628326,-0.027049523,-0.023268819,-0.018465407,-0.010587368,0.02114484,0.05691368,-0.10432203,-0.021371989,0.010259768,0.010736632,0.06390955,-0.021197617,-0.052606788,0.14898403,-0.031120691,-0.043440327,-0.04859654,-0.05417423,0.07020428,0.004105703,0.020308083,0.07475229,-0.032613635,0.033213772,-0.10787685,4.0663134e-33,0.015055872,0.01548195,-0.0130661465,0.026901355,-0.002527201,-0.023672353,-0.06710675,0.0409525,-0.0003403195,-0.07362896,-0.05163013,-0.06168894,0.06942059,0.0119672455,-0.07092876,-0.03738352,0.02697012,-0.031183215,0.056201294,0.016105808,0.043153033,0.063721135,-0.05866913,0.06109885,-0.018713765,0.042626318,-0.10551632,0.094724484,0.0059671826,0.0036711767,0.042529304,-0.16028954,-0.082578726,-0.03443776,0.07090213,-0.004899662,-0.10091489,-0.07157202,-0.016195595,0.041621592,-0.07500159,0.01945114,0.0050565773,-0.0116294,-0.022683905,-0.028398091,0.0057932665,0.073027946,0.032245465,0.07837005,0.05278116,-0.005299165,0.08354828,-0.073480345,-0.05336633,0.045140333,0.007771583,-0.069293216,-0.019120716,0.023202704,0.056769438,0.022060372,-0.060131118,0.037567813,-0.019122144,0.043949153,-0.08127837,-0.0072477986,0.03250878,0.067517534,-0.04556712,-0.004202612,0.057613183,-0.020830426,0.028401388,-0.006109481,0.03046073,-0.011059008,-0.0013219053,0.012944839,0.021545326,0.015270125,-0.009976809,-0.05080959,-0.0022888386,0.028387435,-0.049349688,-0.088164695,0.006314269,0.05241147,-0.012732034,-0.021307947,-0.021481682,-0.0016506541,0.08066363,-4.9543773e-33,0.08687424,-0.034472793,0.0506337,-0.028022274,0.026103556,0.053601235,-0.053727336,-0.05859492,0.033445403,-0.024682377,0.06955007,-0.012630803,-0.017464483,-0.013873569,0.02514746,0.0753557,0.016032659,0.09054327,-0.019186929,0.026405869,-0.04183563,0.14525959,-0.0065805796,0.009802894,0.027249593,-0.047867056,-0.0016138322,0.033626758,0.081267886,0.016353376,0.025187066,0.0063075544,-0.061530285,0.051659405,-0.020779883,0.036911048,-0.051409133,-0.004180693,0.046569057,0.036889624,-0.004423971,0.026557494,-0.034884747,0.04249065,0.08187673,0.06318043,-0.025459526,0.033454992,-0.026249822,-0.03835198,0.077831954,0.03164068,0.019411946,0.07204914,0.073202305,0.07596443,0.13515097,0.048423976,0.010466071,0.033510726,0.0023618676,-0.10772083,-0.004683406,-0.04171856,0.027667763,-0.03278375,-0.017713623,0.14638235,0.038461924,-0.0017628153,0.09975891,0.056738812,-0.015957503,0.0044430224,-0.084888615,-0.033817355,-0.08664339,-0.0063449885,-0.06272401,-0.039638773,-0.039000418,0.01138435,-0.020466805,-0.087713405,-0.032085534,0.0102910325,-0.014473002,0.068494566,-0.029305303,0.055230398,-0.040895957,-0.0373185,-0.023642527,0.07795006,0.07257091,-4.4397485e-08,0.0032759102,0.024972346,0.023167819,-0.06639421,0.029690376,-0.026956877,0.02016177,-0.015859969,0.0019431055,-0.03692595,-0.03662688,0.04644292,0.013843319,0.0009790191,0.049947806,-0.0014556593,0.0072594592,0.06281189,-0.00062206626,0.046420127,0.0048182094,-0.033187553,-0.14412843,0.017721804,0.03876322,-0.07169236,0.047681544,0.014612972,0.04986595,-0.03638814,0.053955667,0.0009887799,0.03334077,-0.0320607,-0.10251625,0.043594353,-0.055677377,-0.02600585,-0.04949372,0.048768997,-0.009431502,-0.040990338,-0.007359763,0.04113576,-0.07695152,0.038317896,0.05888962,-0.0344131,-0.055286843,-0.011069983,-0.0073846118,-0.04225729,0.020411858,-0.05083555,-0.07417884,0.05210277,-0.02004218,-0.014017635,-0.010651253,-0.059563365,0.001097478,0.07005116,0.13738903,-0.040421292 +1.3.99.29,"The enzyme is involved in carotenoid biosynthesis and catalyses up to two desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)] and EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]).",384,1.0,-0.07497555,-0.034450896,-0.07421396,0.009627387,0.021046186,0.030153569,-0.066169485,0.06480916,0.027529519,-0.046722047,0.0033565322,-0.05816219,-0.052811284,0.007655744,0.0040738024,0.03529897,-0.10898535,0.00313366,-0.06074941,-0.061671164,0.12275221,-0.030616483,-0.053079758,0.0038857674,0.10570833,-0.017228004,0.03840822,-0.06732465,0.009137158,-0.04769584,0.012096269,-0.068978995,0.0034410956,-0.0021280814,0.02904007,0.033973947,-0.06349127,-0.07329533,-0.010402247,0.043321576,0.0776479,0.0054453174,-0.07006878,0.021286774,-0.0018548467,0.026041847,-0.09187581,0.11995853,0.0036175528,-0.028275037,-0.06818059,-0.022779576,-0.020571198,-0.04507975,-0.019274823,0.04761758,-0.023452558,0.03836687,0.013935208,0.039364677,0.11289362,0.0032385876,0.017637806,-0.056629937,0.0632396,-0.024306128,-0.040162724,-0.1174873,0.08532302,-0.079074174,-0.045368314,-0.0548877,-0.0020176368,0.0056153038,0.027813775,-0.006830363,-0.05487662,0.04258847,-0.054914404,-0.05340896,0.11277449,0.042065922,0.0134956315,0.06539738,0.053302493,0.034136966,-0.014134626,0.031812552,0.027852308,0.030953938,0.014337537,-0.071666315,-0.08587629,0.06310508,-0.03884251,0.040446203,0.021532325,-0.0008084503,-0.018297615,-0.044203877,-0.022994587,0.06265617,-0.025158258,-0.0035834515,-0.035329312,-0.021196103,0.05761928,0.01903163,-0.033603527,-0.015229401,0.0233089,0.0508643,0.06858871,0.0047010877,-0.038987834,0.13484965,-0.037298582,-0.01398871,0.0057088984,0.008232469,0.05112508,0.0053275307,0.025418568,0.061263088,-0.031951517,0.053232457,-0.112901226,5.1807996e-33,0.0035644677,0.036431074,0.0008332969,0.012979575,-0.025734212,-0.048635796,-0.07891897,0.03917311,-0.019880164,-0.07576244,-0.090620756,-0.06852537,0.0429112,0.06168646,-0.098385334,-0.053449333,0.026569474,0.0044527836,0.025615122,0.014894754,-0.00714541,0.05418679,-0.08952526,0.0791169,-0.022093527,0.029381286,-0.09832414,0.058924686,0.048923437,-0.0045231883,0.011537834,-0.13823602,-0.083540656,-0.010188144,0.056305908,-0.021937186,-0.062495906,-0.08338645,-0.030618723,0.05779204,-0.028887132,0.03319313,0.008322654,0.0040416075,-0.03966207,0.013780296,0.004417531,0.047879014,0.08103119,0.05544676,0.025063852,0.028151285,0.076685004,-0.054182954,-0.041576013,0.004512099,0.008837226,-0.046903476,0.024174953,0.0023244563,0.020246139,0.045115214,-0.06526422,-0.028557977,0.022158928,0.050120983,-0.07376942,1.3645405e-05,0.010709714,0.016351938,-0.0733748,-0.027583554,0.038925402,-0.0075946758,0.019890381,-0.003921089,0.014402965,-0.025089724,-0.013816067,-0.021943787,-0.013866805,0.07095721,0.012611842,-0.073643476,-0.0075655575,0.014240795,-0.028306454,-0.071533695,0.033015206,0.051721033,-0.055412292,-0.03735317,-0.047662955,-0.027181325,0.07327131,-4.7367177e-33,0.031971343,-0.054699235,2.827e-05,0.024016196,0.014064753,0.00730847,-0.06947702,-0.041990567,0.062753834,0.02769238,0.06927925,-0.0137514565,0.020874761,-0.049243085,0.031728275,0.07761567,0.008595609,0.10812795,0.018393548,0.011626378,-0.01913761,0.101527415,-0.03698814,-0.0043540383,0.06669641,0.010057832,0.020753965,0.044292275,0.07021324,-0.016690155,0.008531062,-0.031256296,-0.040328704,0.06161349,-0.060274567,0.0490666,-0.076342575,-0.04311485,0.042863123,0.029757438,-0.044187654,0.02168469,0.018972306,0.06677404,0.059903197,0.052326895,-0.029755073,0.06093394,-0.011119687,-0.02278137,0.08304982,0.021311766,0.01649501,0.060816836,0.011917796,0.07454389,0.13664098,0.08345124,-0.040028796,0.006851057,-0.0031279847,-0.07129588,0.00026275968,-0.065140344,0.009162518,0.0019403073,-0.026988933,0.15026146,0.060767844,-0.025908293,0.06810002,0.04123312,0.010362299,0.009356993,-0.08633369,-0.04121979,-0.08343407,-0.009119285,-0.013630952,-0.06531776,-0.024554666,0.006610291,0.006839761,-0.061433457,-0.016383335,0.018984474,0.010413769,0.08212835,-0.02046142,0.07050747,-0.026074858,-0.07228397,-0.03712048,0.10037678,0.106767714,-4.4867694e-08,0.034290135,-0.01986517,-0.0012506465,-0.045116827,0.060696755,-0.06285425,0.017283075,-0.0035867672,0.0053745476,0.007851124,-0.026497776,-0.021214584,-0.03148357,-0.015095965,0.03784323,0.015420382,0.02490663,0.074381545,-0.0060783452,0.10925226,0.03236807,-0.023506567,-0.15632966,-0.009580077,0.043549884,-0.07971456,0.051000167,0.044194806,0.006552302,-0.0023174887,0.05169375,0.010882523,0.030356474,-0.03628109,-0.07822969,0.024649618,-0.060734294,-0.034594297,-0.029575296,0.031512618,0.0005464736,-0.037328497,-0.001525225,0.039116565,-0.09204688,0.014934078,0.015712239,-0.012672812,-0.020228675,0.017667664,-0.01650534,-0.050615847,0.010147017,-0.0035353072,-0.093644395,0.024068907,-0.016914126,-0.0048689228,-0.017345352,-0.045302033,-0.042832833,0.10786823,0.20837504,-0.032350168 +1.3.99.30,"This enzyme is involved in carotenoid biosynthesis and catalyses up to five desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] and EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]).",384,0.9999999,-0.08783833,-0.028290248,-0.07280116,0.01365346,0.03584893,0.02580826,-0.06875713,0.06171698,-0.00090653956,-0.061549257,-0.016763344,-0.062367357,-0.04873744,-0.011280661,-0.002296995,0.03079909,-0.10420352,5.2545904e-05,-0.056376286,-0.05072804,0.12752494,-0.04874099,-0.054670736,0.007861551,0.09284263,-0.010963589,0.06222415,-0.07495482,0.016192831,-0.05989973,0.0059553497,-0.06470792,0.018988999,0.0053806216,0.023611702,0.03492817,-0.06720679,-0.087652,-0.0051264944,0.047346532,0.075306796,-0.005527517,-0.07700461,0.006005678,0.017541679,0.0060655726,-0.09382296,0.12273117,0.0062011126,-0.045120735,-0.056461852,-0.0084316125,-0.03306041,-0.020736746,-0.035540763,0.040303715,-0.014898504,0.009001232,0.013580778,0.03448245,0.1270942,-0.0015307929,0.016486026,-0.06101582,0.049803894,-0.013903292,-0.027135005,-0.10853401,0.083893314,-0.06684515,-0.042048354,-0.045507383,-0.02097051,0.025451992,0.013695956,0.018150622,-0.046688907,0.017044924,-0.066509575,-0.047221743,0.11033402,0.05482943,0.030089593,0.06362993,0.06439363,0.03778812,-0.024703998,0.038278062,0.051243927,0.037331488,-0.0021406503,-0.06505191,-0.07832318,0.05394812,-0.059616122,0.050006215,-0.0004099329,-0.008591055,-0.0029252393,-0.033198692,-0.021440055,0.075161725,-0.033776928,-0.030358214,-0.036395922,-0.0030722972,0.066961244,0.05469403,-0.03550593,-0.0074492837,0.013435094,0.0076536317,0.07379101,0.005630338,-0.026320655,0.14365406,-0.019394375,-0.010901634,0.0056743925,0.01913263,0.08611797,0.012523643,0.0036816283,0.055742778,-0.046166852,0.042426385,-0.13304271,4.3826893e-33,0.0011996535,0.035703026,0.0076126945,0.021532234,-0.03056545,-0.028286766,-0.07306181,0.025480755,-0.021295816,-0.07575238,-0.093854316,-0.05757025,0.046049338,0.05101694,-0.10977667,-0.06341245,0.03490653,0.0063537387,0.035638034,0.02204827,0.012938298,0.04400005,-0.101450816,0.053059757,-0.011195846,0.04070707,-0.09946358,0.07321776,0.031494364,-0.0049780477,0.0034108341,-0.13774826,-0.071091376,-0.012009242,0.06633222,-0.023421591,-0.048263535,-0.081124194,-0.0132783605,0.049001094,-0.034509722,0.021784816,-0.0022280244,0.0054421844,-0.031765044,0.0265366,0.0051845377,0.06307523,0.059756026,0.029049132,0.021349264,0.033057213,0.06192128,-0.055110592,-0.053370338,0.016769895,0.011432171,-0.04261998,0.029558206,0.0197124,0.032586314,0.034067232,-0.08417426,-0.011638818,0.026968291,0.03548956,-0.07210507,0.024021681,0.01341595,0.027999744,-0.097051926,-0.019121626,0.047717977,-0.021177985,0.029271312,-0.018341796,0.025825646,-0.02581497,-0.010744311,-0.009197425,-0.027595788,0.054489918,0.0016402692,-0.06767536,0.008209899,0.008778877,-0.035205875,-0.06991027,0.011965172,0.044123195,-0.04963976,-0.036116045,-0.03841404,-0.020992292,0.04349101,-4.3499e-33,0.04249956,-0.060677644,0.00216176,0.009576292,0.0048950138,0.030024296,-0.061881464,-0.037258334,0.05702961,0.025429752,0.078006744,-0.027743664,0.03339291,-0.067465685,0.020560633,0.07734152,0.022141358,0.10226473,0.017722065,0.008975466,-0.030634854,0.11801351,-0.02842019,-0.0029072573,0.056295145,0.003961874,0.013923509,0.057309523,0.07671642,0.017188398,-0.0032438997,-0.029891932,-0.02194429,0.032727405,-0.06457675,0.05403323,-0.05551222,-0.04248796,0.060537312,0.024668736,-0.049509503,0.015053481,0.02159641,0.06645171,0.072920494,0.0628391,-0.016789448,0.047908917,-0.017483104,-0.0068568797,0.087161034,0.010655724,-0.0062038666,0.07857048,-0.0016773766,0.0627673,0.119192146,0.05336664,-0.03749103,0.01707937,0.005554611,-0.07240825,-0.0005726621,-0.05096195,0.015169553,-0.01907697,-0.013227971,0.15665314,0.047104735,-0.022487216,0.06820355,0.043362398,-0.010869092,0.016224146,-0.09375239,-0.067207746,-0.09089229,-0.026308017,-0.018446354,-0.06655816,-0.04003007,-0.007638207,-0.00077624735,-0.075650424,0.0060899113,0.0025493612,-0.004084833,0.08854578,-0.005716683,0.0763164,-0.046428163,-0.07969145,-0.030869326,0.10264586,0.080808766,-4.2945647e-08,0.03926511,-0.01868103,0.006275059,-0.04028566,0.06993061,-0.053814434,0.0057498217,-0.007879161,0.013650512,-0.005112812,-0.016955804,-0.00800726,-0.026064819,-0.008668423,0.03555092,0.012466326,0.033264786,0.09895209,0.0025874232,0.09078499,0.041610986,-0.023839178,-0.14166212,-0.020039754,0.048303153,-0.0854148,0.0585328,0.046056535,0.014393006,-0.023121184,0.03617174,0.018646987,0.032184757,-0.033118874,-0.07084402,0.04717798,-0.045809012,-0.03667898,-0.02324001,0.027158843,-0.0055305846,-0.023472885,-0.015994126,0.033100165,-0.07861226,0.0011215657,0.025306176,-0.026706602,-0.008628766,-0.0036626833,-0.0046471152,-0.053208772,0.0050385366,-0.008002806,-0.06820123,0.047909252,-0.03415511,0.0015689251,0.0011096438,-0.048185784,-0.025683425,0.11582606,0.20068838,-0.037614863 +1.3.99.31,"Requires FAD. The enzyme is involved in carotenoid biosynthesis and catalyses up to four desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] and EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)]).",384,1.0,-0.08433541,-0.05577374,-0.069543615,-0.0045275283,0.02272244,0.016097188,-0.07860012,0.076623976,0.024446769,-0.048383474,-0.020310726,-0.07327263,-0.07832325,0.01933298,-0.0071292794,0.0066107176,-0.09774036,0.008226737,-0.053635325,-0.056961995,0.11186379,-0.06713973,-0.025079884,-0.015547446,0.08267465,-0.029141879,0.03473338,-0.085860394,0.021609146,-0.044564046,0.012641077,-0.0461423,0.015578166,-0.0047693173,0.021449544,0.038606875,-0.03484178,-0.06547936,-0.025179882,0.045739587,0.07025376,-0.0017416428,-0.044199474,0.016733421,0.026759569,0.015501359,-0.062830955,0.099584945,0.013448751,-0.018183958,-0.049149003,-0.0054857316,-0.030233363,-0.032326274,-0.035683434,0.039816823,-0.0047566798,0.007478718,0.02181742,0.050612316,0.0783777,-0.023465319,0.008283928,-0.08002335,0.051132195,0.0067849653,-0.070844725,-0.11682552,0.07672977,-0.037928905,-0.014689636,-0.03800442,-0.024172219,0.016187591,0.013657763,0.02513065,-0.050128203,0.006877277,-0.048671156,-0.047407817,0.08376282,0.061508358,0.039700672,0.085724935,0.09690819,0.047349155,-0.012879736,0.027167935,-0.004348112,0.050723556,0.0076721055,-0.05541384,-0.09289096,0.045412734,-0.05612579,0.056281943,0.0135709755,-0.030332798,-0.014987637,-0.041269388,-0.029889407,0.06045582,-0.018329494,0.006653214,-0.06301033,-0.028191764,0.04380475,0.044621937,-0.040001538,0.000785649,0.022463795,0.03076101,0.06715483,-0.02198688,-0.037551917,0.09690164,-0.045426644,-0.06453021,0.025800556,0.013552999,0.035508767,0.029832076,0.03154686,0.08914327,-0.0054073175,0.02402186,-0.10939236,5.3440754e-33,0.0117911715,0.06479501,-0.008840051,0.017249024,-0.0471986,-0.0282102,-0.07921407,0.031607535,0.011456356,-0.084453695,-0.076308414,-0.0894715,0.02414414,0.03251432,-0.09231035,-0.04739943,0.056655884,-0.037192263,0.046340812,-0.026980266,0.03343191,0.048654422,-0.07020452,0.06985464,-0.02730502,0.026595596,-0.111458704,0.091825426,0.06082723,0.0040247077,0.015673336,-0.14969373,-0.052939057,-0.00025941533,0.024872536,0.021772534,-0.070775524,-0.07583057,-0.04554168,0.05372898,0.0014994008,0.0507809,0.026873555,0.013416465,0.01412368,0.009206194,0.031827826,0.07309645,0.047026012,0.06439017,0.01622815,0.039347578,0.07208364,-0.019376656,-0.051259317,-0.009072275,-0.011601198,-0.06391186,0.04108938,0.0133975595,0.029552441,0.06260155,-0.080541305,0.02217894,0.01100103,0.06517807,-0.06472842,0.0144387195,-0.0042877435,0.039830286,-0.062072232,-0.04023988,0.028279848,-0.005820574,0.044516377,-0.03473791,0.044626098,-0.031557567,-0.0002902561,-0.022445392,-0.017005928,0.047717094,0.008197038,-0.052772563,0.0010498379,0.007768684,-0.03028475,-0.043261204,0.029669434,0.036910895,-0.04433531,-0.070630305,-0.03162313,-0.0006490512,0.060033333,-4.532811e-33,0.035988167,-0.058336496,0.037085243,0.021320106,0.021152206,0.043065142,-0.06010484,-0.075874515,0.08397857,0.007660347,0.06508804,-0.044307046,0.027731854,-0.041607514,0.0199652,0.07554455,-0.01689359,0.08418124,0.03064267,0.026346806,-0.059869856,0.12766923,-0.031081056,0.04492401,0.07865738,0.01299247,0.008190832,0.03964529,0.060774002,5.977665e-05,-0.0031077762,-0.019984866,-0.0725094,0.032688547,-0.08771959,0.034771472,-0.070474155,-0.026573027,0.022713589,0.057957865,-0.032570317,0.01668858,-0.0040948982,0.08411852,0.05200879,0.0632707,-0.015470206,0.04618708,0.008361465,-0.016634513,0.070182756,-0.00916152,-0.0029043672,0.039163746,0.033102404,0.056264598,0.15537478,0.077416904,-0.03992082,-0.00085029,0.012715319,-0.0903677,0.01820931,-0.07577521,0.020799212,-0.013401373,-0.014360277,0.20065245,0.0335695,0.010022633,0.048206452,0.09173291,0.015340471,0.01824972,-0.071858756,-0.023937622,-0.07893898,0.025083821,0.01283402,-0.065211155,-0.047141902,0.01516572,-0.016802276,-0.04425031,-0.014869989,0.01391143,0.033219714,0.05749188,-0.029187204,0.06767036,-0.041748255,-0.056578483,0.019882636,0.09762123,0.09156171,-4.7188745e-08,0.031483855,0.0070452476,0.009279896,-0.06453329,0.062848605,-0.051421374,0.0067802817,-0.032477364,-0.007902185,-0.019168047,-0.05908447,0.006250544,-0.0070524476,-0.0026447258,0.028104214,-0.022575324,0.02673133,0.087272316,-0.01854282,0.07783771,-0.0059093246,-0.008430241,-0.16961639,-0.017810019,0.039725423,-0.08714827,0.070611276,0.0090491725,-0.0021846935,0.0034814186,0.051737,0.0051736836,0.012531781,-0.03433635,-0.0850784,0.046555556,-0.0104174195,-0.035077877,-0.047982384,0.009018061,-0.0032643527,-0.003876644,-0.0034291868,0.012829111,-0.09493789,-0.0005309349,0.014140956,-0.026942264,-0.03895497,0.015504256,0.00063382933,-0.061989423,0.008775938,-0.016602555,-0.066136844,0.021639032,-0.0245648,-0.024417475,-0.032968707,-0.0636621,-0.0062027136,0.098715,0.18407674,-0.02737618 +1.5.1.36,"The enzyme from Escherichia coli W catalyses the reduction of free flavins by NADH. The enzyme has similar affinity to FAD, FMN and riboflavin. Activity with NADPH is more than 2 orders of magnitude lower than activity with NADH.",384,1.0,-0.047396492,-0.035952553,-0.08729777,0.06433992,0.07093374,0.077828705,-0.049890626,0.048625257,0.08606859,0.010203375,-0.018814456,0.01907539,-0.08481431,0.08695961,-0.02199655,-0.01578072,-0.07690426,0.03768204,-0.03819293,-0.03633566,0.028240262,-6.471985e-05,0.059114236,-0.007283111,0.016883848,-0.008788509,0.030210225,-0.05053673,0.027767833,-0.023494044,0.027038047,0.018782092,0.056802988,-0.0428817,0.03002862,0.07767807,0.050036307,-0.06487469,0.0012782404,-0.019665057,-0.029087057,0.013049101,0.01627804,-0.029257903,0.010374501,-0.0051493286,0.008269736,0.110399015,0.033416804,0.01461082,-0.043360326,-0.024932716,-0.09550292,0.031265944,0.07814032,0.005716471,-0.015578914,-0.08554966,-0.061264113,-0.042871997,0.019015249,-0.011754364,-0.031544585,0.025019156,0.056946933,-0.07594572,0.033406686,0.011357711,0.020073269,-0.019376125,-0.06412029,-0.004792542,0.006630831,-0.0061374404,0.0054245866,0.03152085,-0.032162223,-0.02780506,0.043305527,0.025001628,0.08420379,-0.029200984,-0.007451261,0.1201285,0.024969533,-0.01641467,-0.043584652,0.0014770807,0.04542707,0.04405608,-0.0073043415,-0.03353333,0.0008924925,-0.06706461,-0.11756129,0.027131632,0.049083423,0.001920908,-0.041182265,0.014452487,-0.022781331,0.072703525,0.047747105,-0.045174412,-0.04858717,0.021897579,0.014136443,0.14162056,-0.037592046,-0.021445578,0.027162846,0.023591144,0.042750493,-0.013916146,-0.099959865,0.114616275,-0.008965047,-0.078803204,-0.13542347,0.016825018,-0.03519419,-0.017145693,0.07670625,0.08461443,-0.0055405777,0.016991096,-0.13487566,3.8798025e-33,0.09134186,0.011777874,0.008587662,-0.08657571,0.06329703,-0.041364335,-0.05366481,0.034901205,0.0083912825,0.0006689789,-0.04296103,-0.038231,0.094296634,-0.043803114,0.058012847,-0.0597385,-0.0051813712,-0.07717532,0.00216791,-0.012126056,0.050574508,0.031008994,0.031117067,0.06322909,0.03620182,-0.0027932664,-0.08291012,0.031513605,-0.04310092,0.0012012543,0.040726326,-0.07504852,-0.08880914,0.030809678,0.06723671,-0.0072114365,-0.11027381,-0.064120024,-0.018824616,0.05778543,-0.02878884,0.0061064158,-0.021120815,-0.021710798,0.06463292,-0.12345661,-0.03241006,0.06197871,0.023439564,0.120161496,0.11954953,-0.017132832,0.05308038,-0.03194769,-0.034117777,0.044721957,-0.006027766,-0.013524092,-0.013730203,0.06804119,0.006303921,-0.018943673,-0.049052462,0.069027625,-0.053211678,-0.023973294,0.0008453934,-0.090265535,-0.0021229098,0.11778649,-0.019491665,0.013580682,0.03637439,0.0274398,0.051048614,-0.011034331,0.017088756,-0.02542338,0.006773348,-0.01451614,0.026298905,0.0028563072,-0.015155301,-0.030649867,-0.041287962,0.046740677,-0.0044994983,-0.06647723,0.007516726,-0.007856526,0.048645712,-0.07795287,-0.038522266,-0.07235747,0.057008594,-3.9955406e-33,0.025134388,-0.08398608,0.005907814,-0.106953464,-0.08284797,0.097407855,-0.017165411,-0.06728309,0.030958703,-0.08149845,0.0010539589,0.033065822,0.011816874,0.00869922,0.037764046,0.017021012,-0.01729245,-0.016605938,0.0010973277,0.018205391,-0.0074547646,0.08518222,0.051815726,-0.034531612,0.033847976,-0.031204026,-0.03175424,0.056438114,0.054256648,0.11793331,-0.056942925,-0.032744393,-0.07133215,-0.04465444,0.005085366,0.031004662,-0.017742328,0.07248955,-0.026575778,-0.00469101,-2.5956732e-08,0.018720573,-0.054444782,0.027127888,0.012224753,0.08738521,-0.13664813,-0.046519306,0.038551077,-0.04368954,0.041461784,0.019699879,0.003860986,0.010347363,0.05771897,-0.009726345,0.046588037,-0.029001854,0.027310263,0.005610342,-0.01448643,-0.10453001,-0.015226234,-0.0056214584,0.11177179,0.037273087,0.043274645,0.06303504,0.024708714,-0.06423969,0.06315387,0.032443546,0.038726952,0.06642754,0.022688113,-0.012711342,-0.06449556,-0.0029765365,-0.041311596,-0.031968866,0.03288643,0.049314238,-0.024565842,-0.12467781,-0.032772064,-0.008890374,0.015026317,0.05163772,-0.0071050962,0.06057477,0.023281379,0.051657066,0.07353612,-0.033791583,0.017929267,-3.197235e-08,0.009834573,-0.06597041,-0.006310216,-0.014720779,0.021534618,0.0894446,-0.019466767,-0.022642087,-0.019278236,-0.016762469,-0.04301546,0.13221832,0.039631616,0.046818744,0.031578295,-0.05227947,-0.05571913,-0.018753283,-0.07598519,-0.050046302,-0.031491924,0.07805973,-0.09273333,0.041968226,-0.0013541967,-0.03859796,0.015228636,-0.042272028,-0.018661482,-0.045516875,0.0055899057,0.015880464,0.054521214,-0.027105935,-0.13016865,-0.019756228,0.022584021,-0.017047698,-0.06835232,0.07456595,-0.028616609,0.031124353,-0.04905602,0.0022978473,-0.009498542,0.0056687533,0.031654555,-0.00736458,-0.0018340794,0.023104407,0.10119894,-0.014023957,-0.015865818,-0.055036724,-0.13648207,-0.011554465,0.010023625,-0.05349668,-0.011811728,-0.0615935,0.014566771,-0.013768434,0.121890314,-0.016778726 +1.16.1.9,"Contains FAD. The enzyme, which is widespread among bacteria, catalyses the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron. The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine [3]. cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].",384,1.0,-0.018565675,-0.060208574,-0.14357737,0.061833795,0.097672515,0.014369226,-0.059347518,0.047580484,0.035457768,-0.06450203,-0.063736916,-0.01115834,-0.06509849,0.010522542,-0.03403103,-0.08275833,0.028199267,0.017456079,0.011243979,0.00931526,-0.024953539,-0.033688817,0.037719645,-0.034846492,-0.0788499,0.024648886,0.054278634,0.033430085,-0.10783083,-0.09547658,-0.002781295,-0.008397247,0.05229924,-0.09064553,0.041561294,0.07254429,-0.02813302,-0.078898184,0.06148558,-0.014784048,-0.048503134,-0.012130255,0.022129757,-0.034779757,-0.028156038,-0.04328674,0.039427858,0.002060288,0.04613319,0.0056552505,-0.08419371,0.02171238,-0.07342559,0.07827092,0.025438257,-0.020664431,0.0035037221,-0.10224313,-0.024058418,-0.0066044866,0.009520094,-0.04822613,0.007143824,-0.026720988,-0.019843532,-0.03209684,0.04677848,-0.087582335,-0.03425199,-0.04348252,-0.08431331,0.016947689,-0.0024437974,0.004540082,0.009706789,0.056260314,0.069146745,-0.019327218,0.04569442,0.0033202665,-0.004725779,-0.018959654,-0.0042734747,0.071332484,-0.0025501014,-0.00014263098,0.0014125333,-0.026451075,0.047004584,0.08145058,0.053514045,0.06954157,0.04492099,-0.067747004,-0.059014346,-0.03866953,0.0024830096,0.053011686,0.020903884,-0.039998837,-0.05418886,0.07953351,0.01123205,-0.054967657,-0.0023579905,-0.013774655,0.014768181,0.23128928,0.028272452,0.021416685,0.016745118,0.030365894,-0.014164725,-0.00472805,-0.009985758,0.045121867,0.09261531,-0.048719283,-0.10327347,0.05498651,0.06258311,-0.022201186,0.03570269,0.0022453293,-0.020376673,-0.022845933,-0.12707411,2.9563141e-33,0.050497625,0.07212112,0.005291943,-0.030241108,-0.029609306,0.022780756,-0.1315539,-0.025471622,0.0026101726,0.037268367,-0.0642009,-0.03727984,0.045422774,-0.04302341,-0.025492731,-0.07851356,-0.021369705,-0.055787534,4.078898e-05,0.019175772,0.10599109,0.079736926,0.05361277,-0.013453154,0.05862242,0.04342326,-0.06584431,0.05481241,-0.023653414,-0.01209842,0.06462316,-0.109506994,-0.093298435,-0.03930202,0.13330743,-0.019393047,-0.00080272515,0.0041089673,-0.03503957,0.017389894,-0.025134057,0.06169056,-0.0064951684,-0.01126924,0.07361361,-0.0801931,-0.06475122,0.11562694,0.043394182,0.03327334,0.0069205533,-0.011875194,0.059005193,-0.007823437,-0.050205536,-0.004073357,0.013363624,0.017325733,0.040532235,0.11575289,0.03198521,0.06621127,-0.0010393144,0.045270417,-0.0067895628,-0.044624902,0.025574261,0.020429783,0.04132571,0.08091019,-0.036594447,0.03204818,0.09617389,0.008017962,0.0014541124,-0.076373614,-0.04245627,-0.06204222,0.103277944,-0.01672536,0.012819982,0.0221922,0.0011911299,-0.015468057,-0.022597535,0.069536604,-0.10870311,-0.022011876,-0.020558149,-0.019308886,0.0367958,-0.047722664,-0.027611924,-0.078172036,0.008318971,-4.8073186e-33,0.08466305,-0.10305463,0.024220675,-0.05567783,-0.056801543,0.045120753,0.035023116,-0.012937819,-0.009075199,-0.008185428,0.047087528,0.02576075,0.031718574,-0.089564145,0.036554918,-0.002367304,-0.008010531,-0.005242312,0.020247635,-0.04393438,-0.019917581,0.03181502,0.048288755,-0.043781795,0.04489477,0.0069415634,-0.04930825,0.045215953,0.012682704,0.04982483,-0.01070104,0.005901966,-0.022112222,-0.076336004,-0.040801942,0.0039569163,-0.067422085,0.01958575,0.052169524,0.007295423,0.04144119,-0.044609055,-0.032725304,0.055095464,-0.021610295,0.046398133,-0.12055715,0.041943308,0.10021087,0.08347194,-0.013595055,-0.051343307,-0.060395088,-0.009722667,0.0575984,0.00780917,0.05285518,-0.0160721,-0.021162624,0.08047563,-0.010357185,-0.026374932,0.06531042,0.04284044,0.072987035,0.050077308,0.023057373,0.07879324,0.09613576,-0.0058135916,0.040057354,0.010787913,0.003374184,-0.00043094103,0.0076043354,0.0037717863,-0.033697672,0.04178898,-0.030722285,0.08130661,0.03926641,-0.0075721964,-0.050952826,-0.04890054,0.02985868,-0.096553475,0.040179532,-0.0028151176,-0.02788773,-0.018900814,0.00191713,-0.055588346,0.044191208,-0.009705807,-0.03297148,-4.2828503e-08,-0.008497849,-0.038045596,0.014787089,-0.056484062,0.06330714,0.0308781,-0.062061008,-0.057784006,0.003951569,-0.012428387,0.012873324,0.109530725,0.014084334,0.00067015033,0.05504604,0.0037849222,-0.03598359,0.012472463,-0.006144442,0.0023555246,-0.028001834,-0.022937743,-0.1016719,-0.01144627,0.038806647,-0.0751703,-0.051472,-0.066164784,-0.032256685,-0.0025025257,-0.04303948,-0.027946014,0.029812543,-0.014233791,-0.023698887,0.004952718,-0.08074224,-0.02249731,-0.05240805,0.051140208,0.011655728,0.014177282,-0.11262367,0.015294287,-0.027315645,0.054713484,-0.062024858,0.058827594,-0.054076403,0.0034777352,0.028599028,-0.010664107,0.030917207,-0.040134966,-0.09155695,0.15261589,0.026946405,-0.055792753,0.010737494,-0.02208184,0.007583909,-0.02933403,0.08926431,-0.025095938 +1.97.1.12,"Contains chlorophyll, phylloquinones, carotenoids and [4Fe-4S] clusters. +Cytochrome c6 can act as an alternative electron donor, and flavodoxin as an alternative acceptor in some species.",384,0.99999994,-0.05452288,0.00039620913,-0.079798125,0.047183055,0.06697436,0.11992155,-0.029525453,0.0067175026,-0.009104165,-0.06500736,0.032298822,-0.11858579,-0.056043968,0.0016594098,-0.007564475,0.07319665,-0.06829159,0.03965958,-0.04836699,0.04787977,-0.10904404,-0.060958065,0.06313536,-0.0054856963,0.016416347,0.014300698,-0.019165888,-0.027643548,-0.007514806,-0.05981283,-0.045868367,0.09748977,0.04216251,0.0016131001,-0.022973573,0.07547633,-0.0001313863,-0.05281298,0.012983708,0.0009669966,-0.04470093,0.042617593,0.02034854,0.023816101,-0.00078523316,-0.060604587,-0.0066608433,-0.00404908,0.056694485,-0.043000806,0.025306918,0.010114037,-0.09830924,0.0673015,0.013541552,0.026074318,-0.0567982,-0.054200407,0.067228146,0.044598915,0.08810051,-0.012294514,0.043452874,0.041239437,-0.019917054,-0.0003110846,-0.044417426,0.023521151,0.048687138,-0.12760372,-0.0074927504,-0.059779502,0.018965455,-0.0035562653,-0.020746574,0.09160001,0.011194643,-0.014152108,0.017257921,-0.0012093558,-0.052216586,-0.061351012,0.004401208,0.13860133,0.1124936,-0.025231253,-0.08666638,0.0018747924,-0.089999594,0.043837868,0.0018310443,0.042368785,-0.02156526,-0.06380132,-0.06550682,0.020198518,0.062443566,-0.037827525,0.074513726,-0.004366161,0.05634542,0.08919671,-0.009931512,-0.11536957,-0.009734782,-0.019320985,-0.037390072,0.06504657,0.050832856,-0.053160645,-0.026929919,-0.020862196,-0.028004128,-0.061851785,0.0065420787,0.015403156,0.038638566,-0.062386345,-0.046639733,0.044402182,-0.060000665,0.06934883,0.045310747,0.0027943365,0.030170128,-0.029661097,-0.11982464,4.1195736e-33,0.055272866,0.042408332,0.04342991,-0.0036319743,0.008117117,-0.0019142294,-0.020365305,-0.006496673,-0.059121136,-0.10775175,-0.13540025,0.021121275,0.06921103,-0.024545088,0.03829612,-0.00262455,-0.040937476,-0.06489437,0.09104636,-0.08066647,-0.00013356969,0.03565975,-0.026083285,-0.0070726783,0.01376468,0.074860305,-0.042029414,0.03410814,0.006281308,0.0033728806,0.0025359988,0.018020539,-0.058296725,0.0011560748,0.020749947,0.03538489,-0.08117211,-0.072727814,-0.06907048,0.04463791,-0.052439462,0.011283589,-0.010949454,-0.02040024,0.08434111,-0.052503254,-0.08700051,-0.052309837,0.0074883876,0.057222422,0.0031686444,-0.08041201,0.03918921,0.031841982,-0.08244398,0.033398625,0.025483951,0.01960569,-0.033311322,0.06961242,0.028455961,0.08227598,-0.050577357,0.024154989,0.05448676,0.037945233,0.016912734,-0.019706527,-0.13871004,0.05402475,-0.014271824,-0.038370352,0.027188452,0.016150149,0.08337857,0.00020158061,-0.03824859,-0.031165555,0.018507445,-0.028416831,0.019941071,-0.05011721,0.07216228,-0.044932034,-0.03153192,-0.016366752,-0.009189118,-0.08463487,0.05661478,0.008248997,0.018052904,-0.079595625,-0.034124717,-0.083186716,-0.043982,-5.030514e-33,0.08174659,-0.064045504,0.051210046,-0.034112617,-0.0024770235,0.052652925,-0.00093263277,-0.12758273,0.04563056,0.025360255,0.086964495,-0.039431866,0.07559022,-0.032840244,-0.025750352,0.004893812,-0.004802474,0.07409812,0.07214738,0.012168373,-0.026106637,-0.005438515,-0.00912994,0.027651094,0.06209098,0.030121244,-0.032912303,-0.08173664,0.13323532,-0.033484835,-0.031460267,-0.031732533,-0.06527508,-0.05590774,0.068257,0.019701304,-0.047632545,0.01732757,0.030078854,0.060915936,-0.022381268,-0.020968221,0.04802109,0.08250123,0.047438107,0.020332696,-0.05660398,0.059142053,-0.010376973,0.040955618,0.07504528,-0.02049805,-0.050447185,0.048537247,0.059591122,0.05014998,0.057819746,-0.027238263,0.023591798,-0.02930559,-0.0254249,-0.12521191,0.02018608,0.0027446826,0.03142897,0.046162415,-0.006885701,0.10864118,-0.01740791,-0.043209627,0.09083238,-0.021623582,0.022589123,0.024780544,-0.027754204,0.003034713,-0.0019032878,-0.01743252,0.037499566,0.013568614,0.04588486,0.030159377,0.052504737,0.01654979,0.025684873,-0.046239838,-0.00085614383,0.002857946,0.0068618576,-0.009217121,-0.027189037,0.057708416,0.051010095,-0.01004357,0.04714666,-3.5779e-08,0.029025236,-0.006775843,0.007822773,-0.031140983,0.0566134,-0.020846609,-0.061992265,-0.016118856,-0.03032805,0.011204703,0.02554084,0.096652135,0.04623471,-0.08603434,0.0043951757,-0.033679444,0.015890352,-0.041805517,0.0063837627,0.062056344,-0.10143835,0.008783866,-0.09129881,0.0034279379,0.040191393,-0.079718955,0.03837676,0.009841524,0.038287096,-0.011835652,0.031863302,-0.0089336615,-0.014782468,-0.025174718,-0.039703898,-0.00890109,0.022277726,-0.11461979,-0.08301864,0.039029494,-0.029749623,-0.056741178,-0.08674218,0.009796918,-0.046683606,-0.023868961,0.05018939,0.01501262,-0.015004487,0.043891646,-0.025356645,-0.045725573,0.032411277,-0.052306008,-0.078915045,0.050156485,0.039948497,-0.0018499509,0.04181409,-0.083031915,-0.02512621,0.0058727083,0.16235253,0.041186847 +2.1.1.209,"Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine2535-N1)-methyltransferase and EC 2.1.1.208 [23S rRNA (uridine2479-2-O)-methyltransferase], whose actions confer avilamycin resistance to the RNA. 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In Rubrivivax gelatinosus the enzyme also catalyses the methylation of demethylspirilloxanthin to spirilloxanthin and the methylation of 3,4-didehydrorhodopin to anhydrorhodovibrin [2]. ",384,1.0,-0.023817213,-0.058872323,-0.15406421,0.0031966204,0.010965956,0.03507809,-0.07739341,0.016827816,-0.009493926,-0.035242222,0.0018056174,0.013660292,0.005482278,-0.0020648867,-0.04461769,0.07371701,-0.08713669,0.05379204,0.018840848,0.03366633,0.1041127,-0.011658312,-0.050839107,0.021916687,0.019294782,-0.023006504,0.045703363,-0.06616383,-0.06617807,0.00915983,0.05354984,0.052222572,-0.023429742,-0.113351844,0.052438017,0.10729579,-0.023802644,-0.011196671,0.12857302,0.07924396,0.017366726,0.008615839,-0.027469467,-0.06714311,-0.07614185,-0.001456621,-0.01937904,0.056992557,0.021785676,-0.029622424,-0.067947984,-0.02881084,-0.04335622,-0.039080918,0.03655029,-0.049496844,-0.06900487,0.017156634,0.019176535,0.00017540208,0.07118489,-0.06663442,-0.0105392495,0.01445126,-0.026408382,-0.09899588,0.046043187,-0.08667665,-0.0033511906,0.01509767,-0.04333082,-0.00040224247,0.019496294,-0.0038020692,-0.027663682,0.06483909,0.012083602,0.0067014047,0.04107522,-0.055378143,-0.015161481,0.0115185,0.02194867,0.059036534,-0.0001020175,0.08793547,0.0893806,0.03664448,-0.005471788,0.10530254,0.061034586,0.078944705,0.041779295,-0.064375356,-0.09029883,0.0373759,-0.011063507,0.017474988,-0.008424822,-0.0321849,0.009957801,-0.06085552,-0.05794636,-0.08942059,0.01311512,-0.030784516,-0.08505685,0.023134207,0.0099478,0.04314466,0.0115028415,0.040726665,0.008571571,0.0012088831,-0.026311634,0.14068238,0.033493336,-0.040441055,-0.089821644,-0.05620615,-0.014572992,-0.032953802,0.04627776,0.038374297,-0.035800595,-0.065455996,-0.10894816,9.48502e-33,0.030456979,0.02480102,-0.012308259,0.0077717165,-0.037804227,0.02907795,-0.093764246,0.038953792,-0.013021538,-0.07707227,-0.1116484,-0.06040033,0.05537005,-0.0077349395,-0.08502494,-0.060501594,-0.0053048218,0.008318614,-0.00340293,0.030210951,-0.020917408,-0.031258754,-0.05737182,0.009715774,-0.030953296,0.02948487,0.013701994,-0.10804247,0.042934593,-0.01716645,0.07674623,-0.10418118,-0.06752659,0.04358561,0.025109667,-0.043048915,0.014186447,-0.08262258,-0.032933574,-0.0064830086,-0.02152163,-0.01925318,-0.012781523,0.0062852018,0.011645233,0.05537098,-0.017028641,0.03104524,0.03928721,0.045461066,-0.023691103,0.017865734,0.18685171,0.0031639654,-0.072412945,-0.022763163,-0.009122993,-0.0029459866,0.017827624,0.014568802,-0.013297466,0.01290975,0.013203842,-0.033222817,-0.022062331,0.01969485,-0.021458272,-0.032789,-0.00776416,-0.047987003,-0.0009423955,-0.013061071,0.056305647,0.000594244,-0.011128717,-0.02119369,-0.011167092,-0.022666978,-0.026666006,-0.00011920811,-0.07688103,0.028814746,0.0354825,-0.054352418,-0.012374013,0.009274547,0.011957876,-0.021839269,0.023163127,0.029837767,0.05893064,-0.115305476,-0.0824091,-0.016683854,0.003041666,-8.621285e-33,0.06862133,-0.096086815,-0.011388397,-0.088320136,-0.01526395,0.031450443,0.058256097,0.009913895,-0.05644384,-0.11513025,0.018428782,0.012701593,-0.035162065,0.0047353883,0.021077402,0.02456033,0.08644209,-0.01149442,0.03520193,-0.06370494,-0.10153152,0.05661377,-0.0044753863,0.050898857,0.0065272343,0.035038274,0.0437758,0.011981184,0.011427201,0.042964183,0.0014102232,-0.002882135,-0.06773926,0.07310283,-0.0074757123,0.060556043,-0.008490709,0.0013421235,0.016775064,0.04685976,-0.035619687,-0.006647557,-0.05469948,0.08956144,0.07022051,-0.008174444,-0.089258984,0.11142188,-0.036475517,-0.010142933,0.021393532,0.0637478,0.06862776,0.034633756,0.04003258,0.002954733,0.015581715,0.029074462,0.043625094,-0.02058933,-0.05693175,-0.04364409,-0.023871955,0.06011827,0.013746156,0.17010236,-0.0028102128,0.03909551,-0.021704113,-0.012708468,0.10363342,0.011658716,-0.01974041,0.050769128,-0.0027571544,-0.05595881,-0.011695459,-0.06954614,-0.049519345,0.005427141,0.021530302,0.034465816,0.03480808,0.017929155,-0.021320384,-0.010083963,0.067698605,0.021227932,-0.028081348,-0.06494302,0.041504115,0.01247265,-0.041301444,0.05641146,0.11371729,-4.554389e-08,0.03469365,-0.02269351,0.06937739,-0.049146276,0.062557295,-0.0018733427,0.038657382,0.017403645,0.028230485,-0.007368961,-0.046407845,-0.02017706,0.026430404,0.030013286,0.12075647,0.026940942,-0.035429727,0.054708526,-0.017974822,0.0014322924,-0.061046597,-0.0009344373,-0.15979744,0.017817955,0.004065037,-0.010094455,0.026177833,-0.03067668,0.063794255,0.028987583,0.0572425,0.005650852,-0.0023520822,-0.0011998015,-0.0513949,0.03984499,-0.05013309,0.035607234,0.011606425,0.018015804,-0.014103712,-0.03200632,0.033329666,0.0064065424,-0.05271456,-0.027573353,-0.059771504,0.01732791,0.104238614,0.048186604,-0.021072226,0.0512115,-0.014846618,-0.056784723,-0.101346545,-0.08115888,-0.044024877,-0.044256642,-0.03630936,0.050039243,-0.052484423,0.08808911,0.17798324,-0.023751171 +2.4.1.264,The enzyme is involved in the biosynthesis of the exopolysaccharides xanthan (in the bacterium Xanthomonas campestris) and acetan (in the bacterium Gluconacetobacter xylinus).,384,1.0,-0.044587113,-0.03907423,-0.13178447,-0.027555889,0.049139544,0.025351126,0.020029627,0.029769044,0.012645964,-0.0024158994,0.097582005,-0.08364372,-0.02592152,-0.018532315,-0.04927889,0.056265652,-0.038945395,-0.023666244,-0.008214165,-0.0034179252,0.07742899,0.041298263,-0.036138453,-0.025295757,0.035215095,0.01053223,0.0009145621,-0.07186752,-0.01906928,-0.03851396,-0.048017908,-0.03234692,0.09911863,-0.03983981,0.07125778,0.08113096,-0.0034309654,-0.038960785,0.12569839,-0.008441373,0.018990237,-0.009713471,0.022609875,-0.029284274,-0.03210231,0.008149557,0.018017989,0.051299755,-0.002386856,-0.012906517,-0.002307214,-0.017489502,-0.05144018,0.0010844294,0.088969804,-0.03721498,-0.018546818,-0.062173795,-0.064574204,0.05214016,0.080358,0.09853972,0.0031048425,-0.0011793271,-0.05396174,-0.11559581,0.035186943,-0.06432774,0.0037823142,-0.03617354,-0.044557717,-0.048611704,-0.009091949,-0.00022577336,-0.032207333,0.009674387,0.026722357,-0.037732206,0.008105562,-0.027774815,0.04708969,0.028074717,0.043561693,0.08059392,0.03162173,-0.051870517,0.0075768484,0.036056668,0.042542376,0.0658125,0.06112612,-0.08051439,-0.020868,-0.040431947,-0.032232046,-0.030422872,0.051784042,-0.055715814,0.03452487,-0.008025419,-0.0133892605,0.009439127,0.01372041,-0.061076578,-0.084065005,-0.05303644,0.03440486,0.09282569,-0.0009717764,-0.001433276,-0.06254056,-0.07458355,0.006498046,-0.003346643,-0.09362488,0.084026635,0.05232312,-0.05277704,-0.11365463,-0.004570861,0.01317594,0.020191096,0.044667024,0.122765936,-0.008353506,0.028084967,-0.069992326,1.6178211e-33,0.0070608747,0.04530074,0.0072757644,-0.113345474,0.087786905,-0.021521622,-0.0091935275,0.00958698,0.0011860357,0.022594886,-0.0492282,-0.12151511,0.0009814439,0.008478052,-0.036171693,0.06388866,-0.119692385,-0.04567595,0.045992937,0.059075482,0.0032748857,0.028564246,-0.03587561,0.031731732,-0.0082933735,0.06415411,0.019216962,0.008185414,0.026615577,-0.0058319806,-0.0023724455,-0.045810692,-0.13035676,0.052371405,0.06380142,0.034795407,0.0038197772,-0.077355504,0.020631596,0.05169244,0.01670365,0.060314238,0.021006584,-0.020767316,0.011620663,0.00478233,-0.060593892,0.05339526,0.10265953,0.031493053,0.015041612,-0.031343754,0.07465084,0.07671827,-0.026776409,0.038340352,-0.09494241,0.033918247,-0.016593229,0.028721882,-0.034387615,0.009657921,0.008861425,0.009330024,-0.030452676,0.033044253,-0.02718859,-0.055205416,-0.0068213004,0.066966094,-0.102361545,-0.11550119,0.055680484,0.011194286,0.018985113,-0.02618221,-0.070277154,0.006086072,0.010892618,-0.012156135,0.051652562,0.0048847855,0.03782104,-0.041307315,-0.11501255,-0.008001654,-0.025074737,0.005219069,0.022076165,0.038087245,0.033609148,-0.05322279,-0.02563337,0.062874205,-0.0077243145,-3.8835655e-33,0.04121343,-0.06452629,0.07670986,-0.06748025,-0.025898037,0.05103871,-0.023862122,-0.042277902,-0.022251362,-0.0014894413,0.03268373,0.048933372,0.034901205,0.019890541,0.0060815453,0.013181757,0.044014957,0.11500105,-0.023026334,-0.04173707,-0.024740292,0.038704846,-0.0010729993,-0.0784229,0.09195695,0.021674022,-0.019659173,0.06423762,0.03282126,-0.00010118698,-0.049022783,-0.022521738,-0.056084804,-0.05423933,-0.046028055,0.011675295,-0.036674213,0.057529327,-0.022248197,0.05340882,0.027977465,0.042945374,0.06680349,0.096509136,0.04768902,0.09265789,-0.07950989,-0.03904183,-0.00041352998,-0.042036675,0.0353453,0.00087739143,-0.021026969,0.005803001,-0.00091829186,0.07019491,-0.0057679657,0.06836028,-0.04284295,0.0011731907,-0.030007597,-0.0631596,0.04498107,-0.018364405,0.058360565,-0.002281561,0.035029445,0.03605408,0.052376445,-0.029470501,0.06393189,-0.022335162,-0.0370642,0.0758161,-0.044447277,-0.0107911425,-0.08637296,-0.11859947,-0.014977375,-0.06487837,0.095562406,-0.02378925,0.032074034,0.020038407,-0.063518405,-0.03251087,0.059572894,0.15571003,-0.011064833,0.0061637824,-0.040188465,0.010877825,-0.023016619,0.027918996,0.08700864,-3.340203e-08,-0.03332565,-0.083520435,0.0074831345,-0.06419845,-0.052734513,0.0040573007,-0.0018513364,0.0010571436,0.08778715,-0.05070414,-0.009534922,0.08547552,0.028086118,0.026548076,-0.0005838227,-0.028569771,-0.0009346566,0.0066740443,-0.02768204,0.021720888,-0.10766983,-0.007817644,-0.10154302,-0.047715798,-0.04712148,-0.10456223,0.052932005,0.061532445,-0.017725272,0.008221478,-0.06681278,0.048827715,-0.016432907,-0.038570896,-0.070474766,0.08886414,-0.087735996,-0.10894228,0.056735016,-0.044976626,-0.007957718,-0.030420657,-0.04739784,0.029003086,0.004069821,0.006307397,0.0430375,-0.00031801526,-0.015614343,-0.0072853323,0.048251435,0.007262452,-0.011692743,-0.079645954,-0.06788253,0.054102313,-0.04107848,-0.019602844,0.034882285,-0.007204288,-0.026774557,0.020882813,0.17769252,-0.050223593 +2.4.1.265,"The successive addition of three glucose residues by EC 2.4.1.267 (dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase), EC 2.4.1.265 and EC 2.4.1.256 (dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly. 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+2.4.1.266,"The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate via the two-step pathway in which glucosyl-3-phosphoglycerate synthase catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by EC 3.1.3.85 glucosyl-3-phosphoglycerate phosphatase. The activity is dependent on divalent cations (Mn2+, Co2+, or Mg2+). The enzyme from Persephonella marina shows moderate flexibility on the sugar donor concerning the nucleotide moiety (UDP-glucose, ADP-glucose, GDP-glucose) but is strictly specific for glucose. The enzyme is also strictly specific for 3-phospho-D-glycerate as acceptor [1]. The enzyme from Methanococcoides burtonii is strictly specific for GDP-glucose and 3-phospho-D-glycerate [2]. This enzyme catalyses the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria [4,5]. 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+2.4.1.267,"The successive addition of three glucose residues by EC 2.4.1.267, EC 2.4.1.265 (Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase) and EC 2.4.1.256 (Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly. 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The first one is a single-step pathway in which glucosylglycerate synthase catalyses the synthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate in one-step from ADP-glucose and D-glycerate. The second system is a two-step pathway in which EC 2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of NDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by EC 3.1.3.85 (glucosyl-3-phosphoglycerate phosphatase). ",384,1.0,-0.059190977,-0.05719661,-0.11490208,-0.034426473,-0.07049424,0.007636898,-0.037096668,0.009658181,0.08727284,-0.018593978,0.051928584,-0.040416338,-0.056279268,-0.044388756,-0.06586394,0.043031134,-0.06035468,0.045777097,-0.040092204,0.058675297,0.111779265,0.016531264,-0.032685142,-0.016460564,0.049069162,0.013099761,-0.0034206945,-0.022251518,-0.038037475,-0.074937575,-0.018558957,-0.030849589,0.097211026,-0.07950252,0.07672579,0.011729226,-0.011068997,-0.0778528,-0.036901176,0.009132728,0.01261982,-0.022985369,-0.028390387,0.050481282,-0.02863531,-0.07685603,0.018550424,0.019494012,-0.0055107796,-0.10161444,-0.055862438,-0.1197931,-0.095788874,-0.0075696567,-0.006624837,0.048532616,-0.05673737,0.11956424,-0.017866902,0.001381589,0.029171785,0.06713452,-0.01571091,0.00134721,0.01178135,-0.05226147,0.08283802,-0.06499133,-0.053999104,-0.043371487,-0.09454177,-0.069446675,0.057195295,0.0041634664,0.018324101,0.1053802,0.05468113,0.014434591,0.0043526464,-0.044780638,0.07264232,-0.0022545073,0.004196845,0.009037846,0.01501472,0.044551823,-0.0083027845,0.014362487,0.008978122,-0.037612986,0.00852403,-0.08560905,-0.057763804,-0.05659408,-0.008845302,0.08315554,-0.015641496,-0.014476471,0.10363261,-0.05743806,-0.012303058,0.09248394,0.035764914,-0.059379987,-0.009972846,0.09064629,-0.021005988,0.069699615,0.020431554,-0.031926155,-0.056676917,0.052939698,0.019551793,0.042926174,-0.083954155,0.07436294,0.039529417,-0.05060341,0.0022295157,0.011563455,-0.024091339,-0.10737547,0.032410253,0.028327897,-0.04005795,0.07846133,-0.037660446,4.964803e-33,0.062185988,0.06438275,0.021177184,-0.020878425,0.046870157,-0.035932105,-0.084446184,-0.04446548,-0.045526013,0.031197263,-0.050830394,-0.0786347,-0.009190214,0.05037627,0.029237578,-0.003312425,0.033124603,-0.05735611,0.0557169,-0.061032657,0.04560238,0.11040714,-0.058485832,-0.059206147,0.042568117,0.11500415,0.03246561,-0.03235433,0.029707266,-0.022306658,-0.0074075814,-0.06925368,-0.052583955,0.043102056,-0.022601359,-7.2463685e-05,0.01250579,-0.022452604,0.05476723,0.04755712,0.010343999,0.004802724,0.014026867,-0.0063266642,0.07693981,-0.0492342,-0.06892079,0.09028055,0.06486803,0.052689735,0.005617513,-0.029207245,0.048881825,0.09826744,-0.056645453,8.006092e-05,-0.03641042,-0.031844005,0.055286776,0.08069285,-0.0064385086,0.061335903,-0.01689994,-0.009608738,0.029045185,0.04185423,-0.095861144,-0.0050773784,0.038306106,0.04186896,-0.03781548,-0.0809738,0.086641036,0.010958905,-0.008262085,-0.060632523,0.021409485,0.009362411,0.017112063,-0.031315796,-0.017327301,0.058964316,0.00837256,0.03296564,-0.04113187,0.036326583,-0.047690902,-0.057943877,-0.022237318,0.10102346,-0.0014914812,0.036265466,-0.036381986,0.024211196,-0.0012952614,-6.0158436e-33,0.08228589,-0.043083962,0.032979265,-0.076970756,0.014168974,-0.012541,-0.021273496,-0.019726101,0.041162927,-0.056204833,-0.03486304,0.021023715,0.048329253,-0.09619108,-0.033591814,0.046456985,0.022047063,0.058676984,-0.054512586,0.013324321,-0.024808602,0.081248105,0.013340541,0.10867393,0.05667233,-0.048769157,0.09609287,0.0350348,-0.017536474,0.049413715,0.07066103,-0.044086006,-0.0073767435,-0.003890548,-0.064573735,-0.0015108588,-0.06921735,0.028467432,-0.008880353,0.021381114,0.0054729995,0.028270217,0.017526625,-0.030271187,0.02993998,0.104631364,-0.036717102,-0.0037511613,-0.016516658,-0.06623259,0.035564855,-0.004262623,0.006713378,0.048056133,0.06360867,0.056147996,0.09159681,-0.024895577,0.009661794,-0.03484995,-0.046152674,-0.047238894,0.03774889,-0.06888209,0.09279168,0.044448752,0.019741584,0.012592688,0.005525323,0.04284549,0.003300184,0.026152378,-0.07146488,0.05233858,-0.016611783,0.015575366,-0.14147435,-0.1312917,0.036854938,-0.05635869,-0.029475162,-0.006530871,-0.013485285,-0.08258607,-0.04529597,-0.051029637,0.034497533,0.11406026,0.024311734,-0.007646875,0.010770536,0.0015101245,-0.015268502,0.019568492,0.12958401,-5.000732e-08,0.0763395,-0.08012538,0.004891684,0.01502041,-0.025844133,0.0047599473,0.02284677,0.05694313,0.07099567,-0.027384577,-0.043642394,0.056620404,0.018436223,-0.035930287,-0.03720261,0.064365685,0.0228898,0.0072443094,-0.03152214,-0.025024984,-0.08483206,0.028608933,-0.08492124,-0.0061127907,-0.010766228,-0.095312655,0.033226486,0.060657084,0.011860868,0.0045790784,0.010643791,0.031179264,-0.027988434,-0.030672964,-0.06577228,-0.007301783,0.008122463,-0.0659275,-0.010377951,-0.014576915,0.058949593,-0.08194844,0.02437109,0.040792067,-0.045205444,-0.005777278,0.0070868162,-0.010581485,0.009327059,-0.013999018,0.09340633,-0.024657233,0.0016324322,-0.12146109,-0.07889791,0.025087457,-0.03386238,0.022846136,0.023458058,0.023159657,-0.000945243,0.012929213,0.12825896,-0.03882511 +2.4.1.269,"Rhodothermus marinus can also form mannosylglycerate via a two-step pathway catalysed by EC 2.4.1.217 (mannosyl-3-phosphoglycerate synthase) and EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase) [1]. Depending on experimental conditions mannosylglycerate synthase is more or less specific for the GDP-mannose and D-glycerate [1,2].",384,1.0000001,0.04763077,-0.017688027,-0.06593973,-0.014441515,-0.018155769,0.012995018,-0.047449194,-0.0024514098,-0.013240624,0.087447695,0.008152516,-0.05396447,0.0018054127,-0.041256905,-0.013029254,-0.081373185,-0.0587605,0.02605309,-0.0016498214,0.026489573,0.14048053,-0.024978554,0.026624318,0.014807445,0.0577686,-0.06274911,0.057410676,-0.10717355,-0.08001588,-0.08691412,-0.0026073908,-0.09719535,-0.013418671,-0.07302776,0.08528335,0.04078668,0.052256197,-0.003909326,-0.0032167814,-0.002598779,0.03227857,-0.108993165,0.04019796,-0.052915502,-0.044847894,-0.024066973,-0.06708849,0.075485736,0.02951562,-0.010888704,-0.1010478,-0.07396647,-0.026433103,0.026944552,-0.015428497,0.08413891,-0.05257722,0.06263049,0.01717725,-0.024215013,0.014130367,-0.042523324,0.092895254,-0.0032064985,0.06265245,-0.059327845,0.011109893,-0.09454206,-0.031374265,0.035813592,-0.03846264,-0.058781985,-0.002760305,-0.0332766,0.036242865,0.06512418,0.0075233765,-0.008283663,0.07769847,-0.015772117,0.03260595,0.054043807,0.028952504,-0.009142158,-0.034426536,0.060811523,-0.0077779596,-0.023691632,-0.013376685,-0.0101969885,0.03655402,-0.025585629,0.05786304,-0.041154202,-0.016251855,0.07614098,-0.0077646365,0.070847094,0.08276921,-0.061655693,-0.011243392,0.04622252,-0.026117222,-0.06630414,-0.023469357,0.053301923,-0.053971067,0.022711577,0.0011948468,-0.004865068,0.023532161,0.013913571,-0.00522389,0.012989218,-0.041916367,0.10883537,0.0053332546,-0.11992723,-0.072519846,-0.011369775,-0.031336207,-0.058964368,0.013636241,-0.006168451,0.0019027005,0.020203691,-0.084892355,3.880778e-33,0.05469421,0.03573373,0.048577685,-0.045173433,0.025839424,0.022867626,-0.053613294,-0.0002760855,-0.079341136,-0.034579903,-0.078865014,-0.073338196,-0.0015386039,0.10250456,-0.05618492,0.054262456,-0.013830283,0.039689235,-0.011748944,-0.077232294,0.004376313,0.04251563,-0.0041270466,-0.012620808,0.08529161,0.09351472,-0.05639259,-0.06268848,0.039987486,-0.0039317077,0.04908791,-0.048744418,-0.049980648,0.046246327,-0.049275305,-0.032324124,-0.04820995,-0.051951885,0.006746818,0.03548643,0.055236723,0.009151204,-0.0074002566,-0.07969977,0.0076967417,-0.031291123,-0.03189698,0.0366112,0.06604373,0.05677535,0.042536426,0.045003306,0.106185175,0.01650779,-0.013860881,-0.001293542,-0.051824782,-0.073631,0.08979626,0.029954894,0.0041868044,0.08856209,0.0076680337,-0.01007001,-0.032013357,0.064587705,-0.039100554,-0.007005879,-0.024478655,0.031518992,0.01352088,-0.07992246,0.064979464,-0.017754009,0.059637442,-0.0706864,-0.0052942205,-0.017244833,-0.040388774,0.018107196,0.059388094,0.021955349,-0.028831672,0.055584025,0.008907209,-0.011778909,-0.06161682,-0.07381585,0.032055967,0.07508929,-0.022002919,-0.05986703,-0.12493971,0.0025608735,-0.08364507,-4.8141027e-33,0.11078741,-0.032703515,0.016092604,-0.03737849,-0.00914778,-0.04772322,0.04240463,-0.0075569088,0.08946777,-0.07865206,0.051939372,-0.0121340705,0.0448706,-0.049667794,0.026478818,-0.005424417,0.046070427,0.022023043,0.01634556,-0.011767263,-0.019917455,0.03085305,0.015158021,0.058329742,0.084693134,-0.06348914,-0.00935981,0.09923996,-0.01884951,0.03574678,-0.036774628,0.04802652,-0.025148831,-0.0010405644,-0.02401258,-0.024262115,-0.1170379,0.035405613,0.02868731,0.010001762,-0.01681545,0.004204575,0.06513492,-0.012938906,0.087886974,0.034024864,-0.009376444,0.06930674,-0.045688026,0.014575906,0.057029754,0.007844453,0.00035814894,0.07755234,0.0709893,0.085450135,-0.03586927,0.036839586,-0.012715416,-0.035240807,-0.100467265,-0.065431625,0.047689743,0.0003912888,0.09678656,0.08669063,-0.07991687,-0.008808528,-0.034827128,0.050406273,0.095160045,-0.010308839,0.025544265,0.03744331,0.0022735281,-0.019982476,-0.122337885,-0.03815359,0.00058953644,-0.021179024,0.0032405886,0.030559232,0.077874176,-0.06405351,0.034080274,0.015943564,-0.025810476,0.049468856,-0.02127786,0.06379162,-0.060260635,-0.055628803,-0.04016678,0.033610504,0.07478167,-4.3268464e-08,0.10994981,0.019713785,0.10176842,-0.039619822,0.06059636,0.027907085,0.057676945,0.003949219,0.007834098,0.0029620405,-0.040030356,0.025481453,0.08375462,-0.046669636,-0.0049688444,0.0153184,-0.036749605,0.068842866,-0.062905066,-0.022467164,-0.06636659,0.00581765,-0.07416877,0.0652092,0.034978233,0.034880407,0.07642561,-0.07673946,-0.030059628,-0.020725602,0.027181976,0.034921274,0.045511026,0.014827819,-0.06749208,-0.07651303,-0.054198064,0.011698266,-0.06186247,-0.066883676,-0.038890213,-0.023597306,0.061750457,-0.031910434,-0.018640889,0.002272164,-0.05117789,-0.03684452,0.04571483,-0.011500765,-0.015169121,0.0035672598,-0.051987473,-0.09777385,-0.05229212,-0.041416567,-0.022321243,-0.004317715,0.000499833,-0.00802237,0.07045341,0.009217085,0.17958115,-0.022941 +2.4.1.270,The enzyme is involved in synthesis of 2-[2-O-(alpha-D-mannopranosyl)-alpha-D-glucopyranosyl]-D-glycerate. Petrotoga miotherma and Petrotoga mobilis accumulate this compound in response to water stress imposed by salt.,384,0.99999994,-0.009199567,-0.0265285,-0.04542766,0.0048167743,0.02383783,-0.043374408,-0.02638128,0.07345127,0.014108323,0.014965299,-0.014739849,0.015181741,-0.059337683,0.018824419,-0.07494523,0.050705984,-0.02791219,0.04848808,-0.040351443,-0.009504375,0.069110386,-0.022659473,-0.017691895,-0.0005856377,0.006822772,0.092213705,0.026894422,-0.0059384434,-0.008133595,-0.06687089,0.0065031573,-0.08733357,0.067945324,-0.059346896,0.063442655,0.011991311,-0.013587151,-0.02564987,-0.070245765,0.011070775,-0.021279443,-0.04199032,0.005989632,-0.012226845,-0.07000052,-0.0066373716,-0.02275165,0.017053073,0.030528987,0.07736353,-0.025742175,-0.10850807,-0.086121425,-0.004504893,-0.04810418,-0.024021562,-0.08262304,0.03849089,-0.03204987,-0.0011934667,0.034851637,0.10128421,-0.0014608772,0.026717236,0.051962186,-0.09356299,-0.015260931,-0.037650432,-0.02307848,-0.037975933,0.031108918,-0.045396466,0.027886506,-0.04025312,-0.07104844,-0.012884658,-0.012277295,-0.018127846,0.11028935,-0.007988362,0.10906735,-0.008242081,0.07251822,0.050023645,-0.007952227,0.0529989,-0.027306698,0.02047782,0.11753208,-0.005482219,0.022529496,-0.024739351,-0.06457926,0.01678175,-0.006237507,0.06190929,-0.023931978,0.040966842,-0.032492593,0.005655753,-0.028337156,0.02146059,-0.010726863,-0.059107102,0.01548836,-0.0704461,0.024110623,0.044753604,0.004723837,-0.02639413,-0.016058374,0.046260238,0.018431485,0.03928015,-0.032935258,0.06698542,0.01702297,-0.024199992,-0.044269536,0.0025569566,0.06692924,-0.044692975,-0.030162485,0.05198889,-0.0054709716,0.030734926,-0.0576628,3.9603016e-35,0.10771476,-0.034059014,0.052807037,0.042819574,-0.042580694,-0.05658118,-0.038473547,-0.054936104,-0.104235336,0.022814391,-0.084600285,-0.033387057,0.009111653,0.06990358,-0.0030276978,-0.0062419865,0.07240093,0.0040016514,0.11627248,-0.03228803,0.05628824,0.086850576,-0.009799974,0.026387276,0.033423934,0.10295223,-0.007409815,-0.052006043,0.05117275,-0.00786563,-0.017348705,-0.11112137,-0.042463083,0.05597538,-0.002155265,-0.019112064,-0.055573158,-0.07705966,0.010005081,0.04118945,0.0057071904,-0.06563717,-0.016855389,-0.013207,0.08473142,-0.006506147,-0.077209204,0.03185086,0.0042985347,0.08643676,0.08337178,-0.019480282,-0.007754563,0.1391005,-0.09542279,0.049827483,-0.04898588,-0.04828677,0.052743524,0.07953599,-0.04492085,0.048780818,0.0017028626,-0.03131365,0.051231753,-0.04568277,-0.03561822,0.0107494565,-0.026695434,0.09228967,-0.027023276,-0.092319325,0.050361987,0.10027748,0.007938131,-0.083373845,0.055040464,0.008456428,-0.058893636,-0.028980238,0.00543626,0.0186551,-0.031234652,0.091878146,-0.11256554,0.07803766,-0.032650117,-0.047767136,-0.028852565,0.09679687,-0.018184332,0.00075327634,-0.087623954,-0.008609267,-0.007872966,-2.1673526e-33,0.08017085,-0.14751108,-0.0005931504,-0.025768252,-0.03744386,0.035196807,-0.0077954624,-0.042219255,0.028881626,0.03293346,-0.01731759,0.001714139,-0.023983747,-0.04273446,-0.025485791,-0.039735995,-0.019924331,0.042859137,0.005689053,-0.0012877677,-0.022980472,0.06354223,0.078641996,0.041095123,0.051859472,-0.037383348,0.016493157,0.0010464814,0.0007616706,0.0924326,0.03139896,0.041695822,0.052186493,-0.052520804,-0.0022220311,0.06064139,-0.03988475,-0.05791243,-0.038565468,-0.0054930337,-0.0787248,-0.0027469746,0.07361142,-0.015589805,0.075450175,0.077252805,0.025231631,-0.04029046,-0.02641481,-0.058930192,-0.010622663,-0.07924373,-0.054508794,0.05981585,0.072927885,0.02028986,-0.022788612,-0.046012394,0.002809519,0.029929705,0.07323236,-0.03707636,0.0028952167,-0.06129449,0.08272221,0.072962634,0.06628461,0.004292843,0.0013302944,0.14671521,0.05091395,-0.06259449,0.023985779,0.08818393,0.057361837,-0.030543951,-0.07655037,0.014017859,0.020815775,-0.097398125,-0.0543184,0.056611083,0.011245985,-0.029920842,-0.0073148017,-0.07149361,0.043213487,0.17539613,-0.012862649,0.01960994,-0.006552454,-0.053115975,-0.03354383,0.044474535,0.03490157,-4.07872e-08,0.026243549,-0.10453775,0.011286256,-0.08720284,-0.018788438,0.042013258,0.06392796,0.025900543,-0.0049171154,-0.009761457,-0.04064424,0.03642089,0.06746546,-0.031403102,-0.040961415,0.078317784,0.08652501,0.018029934,-0.035781868,-0.01989692,-0.06523747,0.010422379,-0.0629771,-0.02901282,-0.004916705,-0.023581952,0.04557063,0.055874575,-0.017015785,0.013161778,0.0035696593,0.02993513,0.005390525,-0.09375985,-0.022283174,0.036082402,-0.01133772,-0.048164777,0.0017866091,-0.060965125,-0.07580762,0.040341485,0.066307865,-0.016454434,0.004365908,0.020190429,-0.048962407,-0.042429093,-0.009711965,-0.009510322,0.010832589,0.033887364,-0.054881852,-0.0488587,-0.1248937,-0.011175102,-0.009791883,-0.059137154,0.007174197,-0.12704293,0.020906478,-0.015998995,0.049273796,0.0040757074 +2.4.2.44,"No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1]. ",384,1.0,-0.019438062,-0.054478213,-0.0690458,0.0075410237,0.045355994,0.05898411,-0.023095798,0.067609504,-0.024804655,0.029200884,0.027536636,0.05491838,-0.02293268,0.09967257,-0.027350146,0.054383874,-0.036907505,0.045918364,0.017983072,0.033454172,0.06934572,0.024598988,-0.093052626,0.074725635,0.066681564,0.06699099,0.04395235,0.050742336,-0.06171192,-0.008048407,-0.10569234,-0.022821827,0.091442615,-0.08930691,0.054551672,0.062249288,-0.057787932,0.017443903,0.13423775,0.027056416,0.007018778,-0.04942465,-0.056882408,-0.03835395,-0.04959278,-0.04484217,-0.024774909,0.030303322,0.05475735,-0.0024666258,-0.005746436,-0.01840158,0.037613455,0.06816626,-0.10429977,-0.01043138,-0.01034447,-0.029982284,-0.06379469,-0.039519012,-0.0063200807,-0.008902443,-0.015957423,0.07206509,0.009571439,0.05877952,0.050733425,-0.024904061,0.03582313,0.02387352,-0.011906919,-0.02980886,0.07879241,0.06430182,0.023052491,-0.0781438,0.05737611,-0.03577409,0.049062334,-0.052088752,0.033540335,-0.032271963,0.026907751,0.038334444,0.008752932,0.0014282565,-0.08504917,-0.004565549,0.048941422,0.0026479168,0.06975695,0.008276362,-0.030588977,-0.124875404,0.014352756,-0.026712826,-0.09460943,0.04287434,-0.03568457,-0.034028824,0.011477531,0.061834235,-0.11818674,-0.0746305,0.084345944,0.08027483,0.08619415,-0.02726344,0.017892538,-0.008321871,-0.029334469,-0.055665214,0.01986535,-0.0024363808,-0.02680344,0.069458365,0.09146577,-0.048792213,-0.11386291,-0.05711782,0.024454782,-0.08791962,0.04625744,0.008812903,-0.052641805,-0.007030908,-0.07727413,3.086937e-33,0.04867849,-0.0061600897,-0.015267643,-0.03720032,0.078520074,0.030813644,-0.007878663,-0.01856292,0.056163494,-0.029521897,-0.124172956,-0.025121367,0.0020946239,-0.025698537,-0.0051547075,4.952927e-06,0.005226844,0.025536748,0.09673486,-0.005032825,0.05156216,0.050845098,-0.0719344,-0.02169366,-0.0065544536,0.09689399,0.015679015,0.0489733,-0.0103923,0.013795071,0.00803785,-0.010351375,-0.069347486,-0.00989465,0.053588662,-0.011613767,-0.033025842,0.05416554,0.07631456,0.06756908,0.026159406,0.09234741,-0.048771624,-0.0045693293,0.030208493,-0.045058,-0.07623878,0.0915614,0.023433127,0.04130512,0.036833864,-0.11858053,0.05539602,-0.068830736,-0.012356062,-0.06748422,0.00034173444,-0.01413384,0.042426754,0.08550882,0.07779304,0.01758091,0.0011746829,-0.025635438,-0.011389068,0.015731797,-0.074889265,-0.04361467,-0.023707429,-0.009549169,-0.03683441,0.01949123,-0.0006565883,0.044702593,0.00448561,-0.040344205,-0.028417863,0.012511614,-0.007754381,0.016715739,0.061951764,-0.099306665,0.028967576,0.011712966,0.0006263868,0.037123583,0.032516226,-0.08570214,-0.056529943,0.0023978455,0.071398795,-0.09117107,-0.06144348,0.03418054,0.03899049,-3.804351e-33,0.051391825,-0.046190023,0.057624117,-0.077663876,-0.08118372,0.081207,-0.0024161525,0.059550323,0.024901634,-0.014624561,0.09667315,0.036240827,-0.052892607,-0.008349941,0.023029616,0.058544446,0.017705953,-0.021955198,-0.082565024,-0.02329012,-0.004582157,0.017614475,-0.02364218,0.06891116,0.09570412,0.025443738,-0.049020503,0.044425897,0.088907674,0.047855057,-0.030185945,-0.014560985,-0.03525067,-0.050940767,-0.010355977,0.055429157,-0.026085125,0.04202253,-0.03538485,-0.03800127,0.058235794,0.011410175,-0.013301812,0.081232615,-0.051844206,0.046856154,-0.10829733,-0.07648045,-0.016435057,-0.12762757,0.012576158,-0.026639666,-0.009557574,0.08790372,0.014000477,0.02949042,-0.0038823597,0.037820306,-0.08777058,-0.044012297,-0.009760478,-0.0392807,-0.075578645,-0.076898344,0.067603335,0.034773275,-0.058859203,0.082718164,0.030663911,-0.05534494,-0.021619579,-0.02123365,-0.004480373,-0.019063937,-0.086654134,0.0069359993,-0.031577915,-0.11383215,0.013552424,-0.008320616,-0.014793641,-0.042627063,-0.052590366,-0.105866835,-0.05291159,-0.056427803,0.056381688,0.096590064,-0.056093566,0.049178064,0.026576035,-0.0191744,0.019728547,0.03566931,0.0040387106,-4.2382723e-08,0.019788746,-0.031410594,0.05660152,-0.0017992444,-0.058682915,0.0461223,-0.015429626,0.03413591,0.03320764,-0.028224656,-0.029905578,0.061101478,0.03465207,0.014408918,0.046416655,-0.01595647,-0.079022154,0.03762354,0.012570155,-0.034029555,-0.051123817,-0.03842521,-0.09458264,-0.002568077,0.0313408,0.0005673024,0.08722873,-0.006524672,-0.0075092344,0.0051519764,-0.02641189,-0.01940773,-0.031588793,0.048535172,-0.0051542814,-0.0058808755,-0.0541995,-0.022228954,-0.086632155,-0.024184486,0.00861865,0.012193127,-0.12573797,0.06547194,0.052023027,-0.005354713,0.053420726,0.044800702,0.016279262,-0.05150473,0.052813716,-0.030507986,-0.025730493,-0.03752815,-0.06077225,0.010006984,0.012535072,-0.020954525,-0.06963069,0.013337146,0.025305556,-0.008087388,0.13179344,-0.0022408871 +2.7.1.171,"Non-enzymic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from non-enzymically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. cf. EC 2.7.1.172, protein-ribulosamine 3-kinase.",384,1.0,0.009262135,-0.04491695,-0.090492934,-0.0021435267,0.057066098,-0.01136008,0.0011778146,0.023979716,0.032484874,0.03384585,-0.04104667,0.13106921,-0.044071935,0.014224033,-0.01747666,-0.06272184,-0.05926641,0.013838053,-0.06612002,0.02695565,0.08558577,0.06906907,0.009518428,-0.013601226,0.11425668,-0.07680104,0.07521387,-0.014257613,0.0020116153,-0.026757834,-0.04784827,-0.0071059633,0.008225667,-0.003126586,0.022144914,0.14781986,-0.044494208,-0.062057346,-0.052649796,-0.05827886,0.04314992,0.028511701,0.054063708,0.019894948,0.013928086,-0.0036449435,-0.058717996,0.050530687,0.08265197,0.045756128,0.00264861,-0.048609726,0.029250018,0.005011416,0.009036201,0.05292782,-0.15291563,0.031398986,-0.046713587,0.03551169,-0.03910922,0.041220732,-0.00666557,-0.0069286614,0.0982429,-0.08377217,0.010862544,-0.012554882,0.011826426,0.05953283,-0.043296278,-0.015728114,0.0057214643,0.037253413,0.042526376,0.0007089759,-0.060564764,0.026657127,-0.020526284,-0.061269425,0.05990381,-0.04934347,0.11319627,0.080875,-0.04500537,-0.037099592,-0.0024344116,0.024389943,-0.02272455,0.009015239,0.0034124255,0.024554735,-0.031786848,0.0037465217,-0.062487982,0.0035317484,0.03599237,-0.051910378,-0.03879873,0.0002965875,0.046105873,0.032478265,0.032682236,-0.008808596,0.0191228,0.07023116,-0.0615627,0.06167025,-0.05365651,-0.011793197,0.022538504,0.085238904,0.056077775,-0.0068468875,-0.050534647,0.0666505,-0.031293407,-0.10748217,-0.018613072,-0.040697113,-0.016621165,0.039747883,0.06884404,0.00200802,-0.09567075,0.11412906,0.015281775,1.4777785e-33,0.06021853,-0.06360334,0.02175381,0.006744505,0.024029093,0.015561221,-0.0674988,0.008485868,0.045124985,-0.031909347,-0.06343834,-0.073595345,0.111069955,-0.035165586,0.008655877,-0.0120088635,-0.0033483475,-0.025756193,0.09258147,0.024652993,0.04845929,0.045458738,0.031668223,0.005098186,-0.010109875,0.04834438,0.010257305,0.015058911,0.03172743,0.021486692,0.008842583,-0.011689269,-0.00034579163,-0.016644068,0.043237146,0.0002838126,-0.07423882,-0.008745755,0.089418285,0.04060099,0.061752293,-0.028398491,-0.0344391,-0.05663804,0.016058207,0.026640095,0.03795032,0.058411013,-0.068060026,0.07361434,0.089315005,-0.051654,0.030411927,0.017945208,-0.05693778,-0.017064033,-0.0604597,-0.067934215,0.010772626,0.031883467,-0.035903394,0.052578866,-0.003251653,0.047831684,-0.046054736,-0.03296644,-0.11167613,-0.054249994,-0.052569646,0.0057490463,-0.051753927,-0.07521642,0.07487914,-0.0016140821,-0.0142432,-0.015755842,-0.053250857,0.009910621,-0.064655095,0.0347517,0.064704254,0.043297447,-0.02935548,-0.020353554,-0.023761917,0.02206285,-0.02091719,-0.15580924,-0.029113224,-0.027914071,-0.017594714,-0.006251861,-0.05812188,0.044527974,0.02764202,-4.6309562e-33,0.11718078,-0.081447005,0.104878224,-0.06613928,0.007895642,-0.045205247,0.025113767,-0.053170323,0.08897901,-0.08047335,-0.0055159526,0.00028929973,-0.014398134,-0.035111684,0.007880754,-0.020614339,-0.09696402,0.06863828,-0.05588586,0.016431222,-0.0050045885,0.04594248,-0.04950783,0.0045845807,0.06793915,0.011394539,-0.07072275,0.03343088,-0.023017673,0.017349167,0.032530114,-0.0058134585,-0.021769455,-0.053496253,-0.015957888,0.0043328335,-0.10639082,-0.03957939,-0.0112942755,-0.04213788,0.020746123,0.08941745,0.035499975,-0.022438193,0.11541561,0.02596939,-0.055730708,-0.009643838,-0.0529181,-0.021938585,-0.009776181,-0.037358537,-0.034586653,0.10220796,0.016338542,0.030614534,0.050030567,0.029745556,0.043372273,0.037679896,-0.05335812,-0.072795324,0.02864596,-0.01754261,0.07909785,-0.041142665,0.047704905,0.052961636,0.05769564,0.06231414,0.017730944,0.016365584,-0.033062972,0.028730353,-0.0135895545,-0.0013965389,-0.10052904,-0.0039418247,-0.07323135,-0.08839809,-0.049965385,0.021472968,-0.030837487,-0.044560947,0.033649217,-0.11573015,0.01711843,0.040103033,0.0064986465,-0.001419729,-0.01582904,-0.07705122,0.006150974,0.02051394,0.0644823,-4.4315584e-08,0.077444494,0.010497446,-0.10316242,-0.03273979,-0.031889357,0.026239501,0.0051275482,0.13508488,0.011400035,-0.04713646,0.033369277,0.082820065,-0.013025765,-0.08662677,-0.04524568,0.02648975,-0.07843713,0.0851493,-0.031121835,0.00365007,-0.04012868,-0.042904656,-0.07852229,0.09729458,-0.02694725,-0.01989984,0.017182058,0.0036603492,0.015329004,-0.026556551,0.02687112,0.046460032,0.12087383,0.026484251,-0.060383428,0.032311462,-0.0003745574,0.04069757,-0.03000499,0.0036545962,-0.047399543,0.0058747823,-0.04008084,0.008692844,-0.061731137,-0.08330941,0.08322057,0.021947639,-0.0033271012,0.02286811,-0.004998478,0.045614656,-0.059853856,-0.083751105,-0.042185098,-0.014923367,-0.14167653,-0.029428631,-0.009127627,-0.047255304,-0.04782349,-0.009271133,0.078602254,-0.01844401 +2.7.1.172,"This enzyme plays a role in freeing proteins from ribulosamines or psicosamines, which might arise from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by EC 2.7.1.171 (protein-fructosamine 3-kinase), which has, in addition, the unique capacity to phosphorylate fructosamines [1]. The plant enzyme also phosphorylates [protein]-N6-D-erythrulosyl-L-lysine [2]. No activity with [protein]-N6-D-fructosyl-L-lysine [1,2].",384,1.0,-0.030563273,-0.06085981,-0.10385146,0.01477903,0.12892203,0.12774767,-0.05526329,0.0048239073,0.098535255,0.07999951,-0.016243331,0.07730599,-0.042886663,-0.00351417,-0.021113412,0.03906553,-0.102158636,-0.014422515,-0.06209544,-0.030722462,0.06954478,0.047359638,0.025759246,0.0054297186,0.069871955,-0.092687115,-0.008630521,-0.045248546,-0.025038876,-0.049130403,0.0015610608,0.022279184,0.031119965,0.022782778,0.008126976,0.13895279,-0.009475256,-0.1231432,0.01880717,-0.014506821,-0.008258887,0.013701685,0.0212441,-0.01788457,-0.04952036,0.062165465,-0.007295764,0.0738564,0.083598614,-0.024930397,0.021237925,-0.04875363,0.056726664,-0.006558334,-0.022861999,0.07632609,-0.08401732,0.045973122,-0.022497397,0.13190316,-0.023305895,0.00653109,-0.0111186635,-0.012007684,0.08033077,-0.050825614,-0.0964383,-0.029724715,0.025917942,-0.008965063,-0.03892051,-0.069019936,0.044504415,0.027317178,0.05593009,0.016603457,-0.054401007,0.055001892,-0.0084489435,-0.03464141,0.023191156,-0.017530756,0.02992233,0.048617866,-0.0484782,-0.0006117738,-0.02562629,0.073223054,0.06575707,-0.025197318,0.04760314,-0.05288996,-0.033794638,0.015897593,-0.054162126,0.024636662,0.048327684,-0.034811873,-0.08122556,-0.046661578,0.050381858,0.034602627,0.022710407,-0.043919783,-0.02235224,0.04304593,-0.025519775,0.03272114,-0.043527655,-0.05828645,0.012529331,0.020120967,0.023137096,0.068418175,-0.059229694,0.0537854,0.0126885995,-0.13689187,-0.07123982,-0.054876365,0.026540468,0.028805539,0.064800516,0.05277876,-0.1087227,0.0397489,-0.10614049,8.494953e-34,0.023863582,0.012422882,-0.021330353,-0.05181675,0.03554666,0.00627225,0.0058123395,-0.0046755606,0.055590935,-0.0320642,-0.09547998,-0.045110364,0.09833734,-0.0096166525,-0.019313037,-0.00377349,-0.012283088,-0.014945064,0.098181285,0.011295538,0.053243946,0.026570225,-0.036908798,0.04384092,-0.0010037371,0.05822459,0.006895554,-0.03234493,0.04675099,-0.01735012,0.034096457,-0.025759181,-0.037787452,0.042500377,0.024861166,0.005310912,-0.09171517,-0.007343172,0.01784748,0.020544115,0.017785659,0.05137621,-0.0044136317,-0.005807341,-0.02306577,-0.0015278633,-0.052980103,0.041640155,-0.042501736,0.07143112,0.107005954,-0.011777415,0.060306996,-0.007179368,-0.05091808,-0.01829949,-0.015018758,-0.04874284,0.022695217,0.03273685,-0.024125343,0.00036217624,-0.029953029,-0.0049056937,-0.0016665237,-0.008806279,-0.080322996,-0.071584485,-0.03665775,0.09900657,-0.0701313,-0.08879833,0.061842695,0.02341879,0.027450183,-0.042114757,-0.07630306,0.0070543066,-0.06893537,0.07047108,0.08599936,-0.0076340353,-0.023015298,0.014963,-0.010535046,-0.038585097,-0.023745822,-0.10412891,-0.00924519,0.004736475,0.036150213,-0.04368125,-0.009322092,0.07758155,0.014488183,-3.2403512e-33,0.12567526,-0.086449295,0.071518466,-0.034341417,0.0173721,-0.012034386,-0.0016946639,-0.0389706,0.025988128,-0.074178025,0.046717193,-0.0007692887,-0.02291614,0.048796516,0.030044008,-0.009855493,-0.062356938,0.082051374,-0.03313839,0.07205601,-0.079336695,0.03484021,0.0014573693,0.012718629,0.050906792,-0.023474699,-0.02805832,0.006494638,-0.0059221685,0.0101889055,0.00374026,-0.030882047,-0.039099053,-0.06170503,0.002112906,-0.004761451,-0.0566432,-0.06823943,0.019207796,-0.010872241,0.051907137,0.09904532,0.058084577,-0.02238689,0.04411981,0.027894264,-0.093926035,-0.0028970009,-0.120998465,0.011628421,-0.012363449,-0.0004939266,-0.004413623,0.037265174,0.053054698,0.0037948317,0.025747381,0.07011999,-0.027124582,0.016091583,-0.035543658,-0.06578984,-0.06445376,0.045769837,0.094287075,0.012777036,-0.0031275982,0.079417296,0.031617746,0.07386894,0.06687841,0.0035484957,0.06465532,0.08183515,-0.048403643,-0.026726691,-0.09722401,-0.04803766,-0.034364812,-0.030789873,-0.029106213,0.016705295,-0.03116194,-0.054552615,0.038753986,-0.07504971,0.045439493,0.07853063,0.013828242,0.008418521,0.020589886,-0.10651792,-0.0024476126,0.04190627,0.16485131,-4.2150752e-08,-0.002688907,-0.033409026,-0.07270334,-0.060379073,-0.01218983,-0.02600369,0.009529087,0.10455056,-0.02955749,-0.0010551303,0.021529615,0.059545193,-0.02568999,-0.033520192,-0.012753822,-0.015640447,-0.012516987,0.09749495,-0.003681929,0.024714233,-0.007956915,-0.026514629,-0.10544652,0.06443939,0.0019431754,-0.06344573,-0.014841092,0.017266888,0.016329162,-0.025185317,0.06091778,0.0114820935,0.0657936,-0.071405105,-0.08048134,0.021163369,-0.02394234,-0.049300905,0.0024211542,0.02177663,-0.012105081,0.044966564,-0.03812594,-0.0071614906,-0.024918437,-0.062249687,0.06183019,-0.039067574,0.0014287533,0.021773096,0.02404638,0.014076836,0.00017936295,-0.11343429,-0.069530554,-0.01965917,-0.08443738,-0.013425381,0.019047005,-0.059050303,-0.016659914,0.005406715,0.13740696,-0.04262798 +2.7.7.74,"In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.",384,1.0,-0.101787284,-0.05454238,-0.032511014,-0.033452794,0.046243623,-0.074428156,0.027007123,0.026354527,0.0592604,0.07202443,-0.016399236,-0.05575779,0.00082227617,0.033752628,-0.07111101,0.055709332,-0.03169868,0.03824637,-0.010017899,-0.048772544,0.09509405,0.03340556,-0.114288844,0.01428438,0.026312806,-0.0043561044,0.047054507,0.008692448,-0.0887937,-0.06894623,-0.06971296,-0.005889893,0.03811381,-0.07801925,0.08705229,0.20680366,-0.07021132,-0.11391942,0.0912414,-0.021075848,0.07645787,-0.012901803,0.048058372,-0.043222982,-0.0033387693,-0.010333708,-0.002517091,0.027394572,0.03861401,-0.05288382,-0.09271803,0.050856244,-0.012798566,0.020700201,-0.022720635,0.044914357,-0.031260643,0.066254824,-0.03885927,0.0107882,0.023368431,-0.039805606,0.029960535,0.053272642,-0.02436605,-0.07084135,0.033508454,-0.006699863,-0.017731743,-0.058937628,-0.111590534,0.007499644,0.028462218,0.05201221,0.056675736,-0.018394962,-0.0009363716,-0.0047298414,0.01150003,0.026059264,0.062777184,-0.032167304,-0.028041935,-0.07905605,0.04293642,-0.017371537,0.0094494345,0.036725987,0.067879185,0.08145191,0.005184144,-0.008538814,0.04542225,-0.061092325,0.012556263,0.0020753131,0.0790348,0.022413673,0.0371665,-0.0915525,0.0017231934,0.0673706,-0.05941053,-0.013670395,0.044468172,-0.02901428,0.004132156,0.04306416,0.043699704,0.02931176,-0.047495168,-0.012419991,0.118212916,-0.021958653,-0.002273921,0.08476201,-0.009763643,-0.031300515,0.03472282,0.016723508,-0.035749212,-0.07871487,-0.036911927,0.09662452,-0.080529936,0.11313233,-0.016826503,3.75868e-33,0.032112833,0.054138113,-0.0028283098,0.048450217,-0.018388838,-0.09472798,-0.044273846,-0.04950762,-0.10210443,-0.052880123,-0.02219985,-0.026604341,0.031676482,-0.021552635,-0.06685564,0.0401298,-0.042509343,0.009080072,0.087172754,0.021949101,-0.06405611,0.064289525,-0.0893136,0.023903888,0.015854944,0.08234607,-0.09688174,0.0073357997,0.030207356,-0.02194361,0.025544351,-0.080377966,-0.16690964,0.034082443,0.05210479,-0.091546305,-0.010865075,-0.05535822,0.00148226,0.039143886,-0.07640419,-0.0071906606,0.042113114,-0.040349506,0.022667652,-0.017145006,-0.058688506,0.039690595,0.04163268,0.02661994,0.062349934,-0.016917672,0.09306395,-0.06727769,-0.07778414,-0.06063403,0.02870347,-0.03244687,0.04719571,0.1075881,-0.049644634,0.028685719,-0.021251546,0.009225905,0.019077482,-0.051290445,-0.0454799,-0.019148272,0.054063126,0.10449782,-0.04285713,-0.027947064,-0.003457793,-0.010890677,0.075752236,-0.014630792,-0.003577683,-0.00480849,-0.033182256,0.051903624,0.03281885,-0.035439864,0.007059201,-0.015184966,-0.054833196,-0.019047992,-0.00446084,-0.056222647,0.022274714,0.05300089,0.03081677,-0.023626048,-0.05388048,0.06752136,0.01236284,-6.519217e-33,0.120370276,-0.085554264,0.06587805,-0.058971196,-0.11955782,0.017681697,-0.0058193635,-0.00072942115,0.07541861,0.01975798,0.05157176,-0.050422903,0.03862283,-0.04550142,-0.03353664,-0.021305425,0.05484869,0.07239839,-0.03799768,0.04046903,-0.016259253,0.077984944,0.018365763,0.073740475,-0.033920687,0.032379974,-0.034299396,-0.0073791454,0.02858849,0.057523295,-0.021366172,-0.024066977,-0.075135626,-0.056355715,-0.04938392,0.00878466,-0.081780896,-0.017698746,0.035193898,0.01948324,0.03284634,0.046901267,0.027565697,0.04497987,-0.024089506,0.020305844,-0.02681947,0.05132065,-0.056326486,0.0035773017,-0.03714976,0.07646845,-0.019497393,-0.028126724,0.029165514,-0.011314959,0.026769781,0.022101507,0.0362171,-0.0889147,-0.021913376,-0.06825463,-0.030683208,0.0016219962,0.009719549,0.12025068,-0.061822694,0.039682597,0.027069697,-0.0018016758,0.043258578,-0.04302285,0.01196963,-0.04632381,0.0068555446,-0.014068745,-0.07170291,-0.011751165,0.06458904,0.013604098,-0.022930425,0.028035583,-0.009016444,-0.09693835,-0.036127917,-0.10642466,0.03059055,0.04642635,-0.019813491,-0.0042372085,0.0051845894,-0.008854183,-0.057754844,0.010168949,-0.0018012709,-4.6940823e-08,0.050883826,-0.03132638,0.026117573,-0.035543323,-0.020390304,0.042231373,-0.01666135,0.027273022,0.072233215,0.064553216,-0.067434505,0.06969252,0.07853567,-0.059190314,0.058874615,0.06920289,-0.06587219,-0.024361184,0.04107843,-2.0602958e-05,-0.016930752,-0.037360094,-0.08548163,0.020881834,0.06084072,-0.013789264,0.04053355,0.06514245,0.047701538,-0.00046022268,-0.045284342,0.0022903823,-0.012507122,-0.0054387506,-0.013620295,-0.02847611,-0.02833279,-0.014092658,-0.036312595,-0.024637025,-0.037395705,-0.054864015,-0.059090793,0.009388523,-0.08402055,0.088061534,0.03874285,0.062080786,0.034199316,-0.018261004,0.009567539,-0.060638778,-0.012891615,-0.053745013,-0.059247036,-0.0029598125,0.030243563,-0.0019994916,-0.020282367,0.016024798,-0.005836355,0.070838764,0.075470276,-0.100825734 +2.7.7.75,"Catalyses the activation of molybdopterin for molybdenum insertion. In eukaryotes, this reaction is catalysed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). The reaction requires a divalent cation such as Mg2+ or Mn2+. ",384,1.0,-0.02453381,-0.11706078,-0.06719473,0.04431122,0.05016553,-0.02129549,-0.024173368,-0.016587066,0.001215614,-0.051650476,0.04561793,-0.029554682,0.011909046,0.012246369,-0.02730424,0.03537385,-0.04188962,0.045736432,-0.006131302,0.030212339,0.018328018,-0.016982509,0.025855,-0.049486138,0.023326265,0.03529368,-0.014288327,-0.073641755,0.04985473,-0.019502698,0.00022887814,-0.011886533,-0.019237515,-0.03139739,0.06518985,0.065535076,-0.013755552,-0.03556364,0.027856523,-0.043444455,0.026749277,0.0037739628,0.08410184,-0.07877483,0.011347184,0.006954624,0.037623793,-0.025348607,-0.017072607,0.04446454,0.051584765,-0.050318792,-0.061798073,0.057867542,-0.011841865,0.030069422,-0.080721065,0.070394844,0.12803255,0.025629004,-0.024137272,0.06569231,0.09557837,0.031418614,0.080286205,-0.13496655,0.028059795,-0.023420248,-0.03389368,-0.018119613,-0.009128755,-0.016507115,-0.01736568,-0.0036238574,0.009632719,0.036170263,0.015877781,-0.0155163715,0.02084878,0.018492911,0.028723363,0.05265098,0.06203367,0.05228118,0.027897116,-0.036704328,-0.033623744,0.010496599,0.020524515,0.025196893,0.069779746,-0.022076318,-0.00065125804,0.009906883,-0.06065825,-0.02915602,0.06718573,0.0018825604,-0.015764251,0.026517913,-0.049790934,0.04922479,-0.06903293,-0.04525312,-0.023226622,0.0034236829,-0.044045698,0.038384337,0.010101429,0.044949345,0.039194826,0.035673305,0.06832318,-0.031206405,0.029016634,0.007151779,0.00870262,0.003271705,0.008415448,-0.050949343,0.011401259,0.004973023,-0.04417736,0.04833495,-0.11996516,0.046810556,-0.033990394,4.461028e-33,0.0883991,0.031244736,0.040011287,-0.006600921,0.019856758,-0.015350429,-0.02639011,-0.053404633,-0.05359753,-0.061752763,-0.06528344,-0.07850852,0.055543646,0.032766473,-0.04307519,-0.040553514,-0.036710467,-0.058853313,0.05957738,0.03310235,-0.017805496,0.04535129,0.009559195,0.022962986,0.056859236,0.063555785,-0.0055896007,-0.04465497,0.04585133,0.018870413,-0.037689026,-0.12092721,-0.11925441,-0.010041666,0.025342986,-0.038514145,0.0029866723,-0.126189,0.030453155,-0.02052211,-0.10924269,-0.06205068,-0.13582112,-0.03643919,0.052479327,0.022238689,0.04304153,0.096979566,-0.0032028984,-0.035295703,0.021982335,-0.07261435,0.014923891,-0.05166837,-0.09285247,-0.00044018353,-0.042937785,-0.071130276,0.036150075,0.09824043,-0.019703748,0.0021376435,0.054946892,0.07049396,-0.001701306,-0.012514773,-0.07192078,-0.0788714,0.060159132,0.011868719,-0.08559899,0.0043034484,0.06313204,-0.008204569,-0.010155822,-0.039296526,0.017440613,-0.070122704,0.024365595,0.03782428,-0.017193291,0.016229589,0.0185813,-0.06610645,0.052308388,0.025832798,-0.1150008,-0.09341975,-0.05754424,0.054110266,0.044714756,-0.0002722744,-0.04044299,0.014637086,-0.02695341,-5.601409e-33,0.099459134,-0.09195757,0.07315071,-0.10552941,-0.14484236,0.014164229,-0.023608338,-0.09085146,0.033133544,-0.045680918,-0.020957137,-0.008845117,0.02494259,-0.04853347,-0.031187147,-0.048107486,-0.01888409,0.1309587,-0.0028754098,-0.036742166,0.08094816,0.0090588,-0.044160873,0.028249966,0.05210345,0.03532915,-0.032383315,0.08590853,0.0488641,0.052784305,0.031778824,-0.009765968,-0.10018922,-0.017963644,-0.021219164,0.07066214,-0.03665054,0.014373006,0.020612158,-0.013702888,-0.028936818,0.021707332,-0.017195592,0.0875125,0.0109045,0.044946875,-0.08220814,0.056493994,0.0876627,-0.037853014,-0.021997975,-0.030286819,-0.02820364,0.007088191,-0.0025725728,0.03300885,0.03931089,-0.027106205,0.07316534,-0.034803603,-0.014630069,-0.026219655,0.07199425,-0.0010830433,0.03504541,0.10262747,0.02328382,0.030036066,0.09456954,-0.036007557,0.08481359,0.04316023,0.0063938643,0.010404345,0.034838013,0.011295729,-0.007307724,-0.045619752,0.013999643,-0.02491018,-0.0015451033,0.04198628,0.037061136,-0.07664383,0.03971749,-0.01687866,0.046644375,0.13612258,-0.004865622,0.0037630368,-0.06325911,-0.016978757,-0.010672492,-0.055866335,0.04647552,-4.1178335e-08,-0.015508165,-0.09668018,-0.0038756232,-0.07528785,-0.010539862,0.12224025,-0.0013089987,-0.022275306,-0.03603583,-0.063112244,0.03422383,0.023483092,0.06161874,-0.08046431,0.041168965,0.08153854,0.009671949,0.004047338,-0.033028804,-0.0082904715,0.0010097445,-0.017048962,-0.06030055,0.13918288,-0.05604913,-0.055502262,0.019899828,0.122238755,-0.04239282,-0.008499534,0.022442205,-0.048075326,-0.0060304473,-0.010756236,-0.015764665,0.04060225,0.01969777,-0.05884432,-0.00095510046,-0.08579212,-0.07746071,0.021059418,0.022346437,-0.010489496,-0.0605503,0.016089367,-0.027654232,0.07478717,-0.039700788,0.08187944,0.06588965,-0.056930687,-0.022078121,-0.010201859,-0.08551746,-0.007209437,-0.034296963,-0.06489876,-0.007557036,0.0038925277,-0.019477118,0.03582809,0.13893369,-0.07792376 +2.7.7.76,Catalyses the cytidylation of the molybdenum cofactor. This modification occurs only in prokaryotes. Divalent cations such as Mg2+ or Mn2+ are required for activity. ATP or GTP cannot replace CTP.,384,0.99999994,-0.05230212,-0.03645312,-0.07748571,-0.044963654,0.019439159,-0.028372686,-0.005697026,-0.02931628,-0.026059171,-0.031842306,0.054433543,0.019104833,-0.0071708634,0.022415848,-0.030731527,-0.029458554,-0.015308786,0.049630765,0.053612832,0.014895651,0.036211442,0.05653675,-0.009727743,-0.047733948,0.010348803,0.051359385,-0.008677263,-0.017497523,0.053976752,-0.064030714,-0.059236314,0.09812881,-0.016227651,-0.07584936,0.090277515,0.081981964,-0.033540703,-0.029546304,0.063645,-0.047912367,0.04283869,0.05880712,0.07146452,-0.01552231,-0.01144179,-0.0070477747,0.05985965,-0.036615264,-0.050819334,-0.04149243,0.024780665,-0.020278241,-0.057122998,0.04011346,-0.013836247,0.047828455,-0.07168484,0.022363137,0.036878567,-0.042711753,-0.043838583,0.042639405,0.036880273,0.033353858,0.05104005,-0.053488486,-0.0031812435,-0.05910066,0.001732998,0.01144487,-0.015904576,-0.00214101,-0.012861793,0.017287917,-0.06511819,0.0735709,0.01761404,-0.03590276,0.066287845,0.04565753,0.0023468803,0.051305573,0.09194507,0.030469202,0.09904571,-0.04108515,0.0036476492,-0.00044808222,0.017097732,0.022716517,0.053152848,0.054562066,0.027289325,0.03585043,-0.1375106,-0.01754025,0.06275071,0.0050941375,-0.002896135,-0.0013365686,0.017883277,0.06618522,0.010089602,-0.0062177237,-0.034139156,-0.0136185745,-0.021860033,0.07650466,0.019759294,0.050597902,0.0059322733,0.06004977,0.051421233,-0.08034614,0.051930822,0.015302994,-0.021004416,-0.008560491,-0.00402063,-0.068933055,-0.022983322,-0.07521474,-0.085766524,-0.0035020583,-0.11994373,0.05393734,-0.080828875,5.9583928e-33,0.08348313,0.026610538,0.026245754,0.0058397255,0.019467955,-0.014223256,-0.032637883,-0.10612076,-0.008154913,-0.11187055,-0.0334463,-0.01788905,0.015182139,-0.0155783305,-0.03520504,-0.029730173,-0.08902752,-0.017430563,0.0810518,0.0064094192,0.006638239,0.10680187,-0.013062227,0.015593516,0.0688956,0.06525665,-0.011063701,-0.06945048,0.018596787,0.030059753,-0.0031543253,-0.095264986,-0.10714739,0.07592476,0.0041705817,-0.029838394,-0.052620914,-0.07697475,0.025024835,-0.00076146214,-0.08896254,-0.0093416395,-0.06573278,-0.04195014,0.02412402,-0.010444982,0.037226785,0.08741131,-0.051684055,-0.018370943,0.054419298,-0.014604277,-0.006767977,-0.004727889,-0.104169086,0.017380178,0.01840753,-0.03736467,0.018083349,0.10015091,0.025903257,0.020704644,0.04609861,0.05778718,0.021702256,0.05295025,-0.1048899,-0.122,0.063054204,0.07599638,-0.101111256,-0.010510579,0.066354915,0.02468266,0.024348084,-0.047931913,0.079595394,-0.03590362,-0.008837182,0.07323054,-0.008688644,-0.0068425555,0.017752519,-0.04207279,0.008505045,-0.0295251,-0.045898754,-0.024708476,-0.019502293,0.05094055,0.08905618,0.002352331,-0.018849373,0.043714177,-0.054547086,-6.315109e-33,0.09582009,-0.10314201,0.070762485,-0.06191341,-0.14754888,0.012145097,-0.0050352304,-0.15064363,0.06703068,-0.056855325,-0.029769968,0.014494379,0.029094055,-0.02546063,-0.04525646,-0.04590051,0.023784537,0.099858165,-0.043440174,-0.020152843,0.03796484,0.055600278,-0.04367838,-0.014668971,0.044266623,0.032384858,-0.053274237,-0.00315677,0.067848854,0.0041141557,-0.0032554907,0.024302406,-0.10759387,-0.045269668,-0.039299782,0.043364037,-0.0032681148,0.014735101,-0.012989961,0.00045245487,0.012620486,0.040313162,0.0455257,0.071981035,0.032334134,0.01680968,-0.06304927,-0.006395567,0.045529682,0.0114123225,0.020544102,-0.0034981144,-0.042872384,0.0027204065,0.026238624,0.038713414,0.049300857,-0.039521582,0.017000156,-0.017007101,-0.031366967,-0.01011121,0.011261056,-0.010945576,0.038404167,0.09547623,0.016854338,0.01287958,0.045526117,-0.008550649,0.014841021,0.111839324,0.0020208044,-0.024084946,0.04110251,0.052616265,-0.051581293,0.0030132725,0.0016450408,-0.055978056,-0.014256081,0.05455491,0.014628725,-0.06901103,0.0047680656,-0.01662608,-0.0062582307,0.12910396,0.06416915,-0.022880603,-0.036663402,-0.051652856,0.004406535,0.021777572,0.0139143085,-3.525446e-08,-0.072535776,-0.029504094,-0.024220841,-0.08043653,0.012382846,0.12717608,-0.007841792,-0.038809437,0.11404933,-0.08168487,0.05533505,0.07064929,0.060239956,-0.061483745,0.008190745,0.065685295,-0.06981311,-0.067861594,-0.02957753,-0.025330652,-0.04540648,-0.042337775,-0.093326345,0.1847328,-0.012260441,-0.031707864,0.023821099,0.06641804,-0.053125776,-0.0140265385,-0.015144755,-0.021458222,-0.020720769,-0.021273062,0.0039461832,-0.020389859,0.038103543,-0.0428475,-0.037459686,0.0047135926,-0.051765494,-0.027430763,-0.033686083,0.017957998,-0.04497261,0.025887024,-0.037776947,0.0035837786,-0.04847137,0.01432944,0.051505666,-0.024779327,-0.04585061,-0.041084737,-0.09143287,0.0068748407,0.030781904,-0.02243598,-0.062269688,-0.0194347,-0.05191095,0.021431912,0.15573232,-0.07916556 +2.7.8.34,"In many organisms this activity is catalysed by a bifunctional enzyme. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3-phosphate, a widespread organic solute in microorganisms adapted to hot environments.",384,1.0,-0.058797684,-0.04419855,-0.056430712,-0.008259483,0.085695885,-0.047111206,0.023139583,0.03109979,0.078655116,0.050643634,-0.007751537,-0.05889956,-0.10715197,0.072130375,-0.06350489,0.05680973,-0.025731366,0.038951896,0.009807761,0.0010431447,0.095107354,0.0069406116,-0.07236575,0.036787093,0.026844252,-0.0076332986,0.06267031,0.01932076,-0.07897684,-0.074976444,-0.035968505,-0.039874732,0.0909903,-0.07118383,0.0730149,0.13920261,-0.047827106,-0.078743964,0.04288439,0.008150269,0.07131837,-0.011951088,0.051268384,-0.0020530873,-0.06106066,-0.024892336,-0.051765185,0.039339848,0.049453463,-0.030322675,-0.05782085,0.030240607,-0.007725432,0.033823267,0.009328264,0.03915914,-0.01622259,0.08469596,-0.03563335,0.0056660175,0.027095094,-0.020049827,0.04395941,0.053635478,-0.065773085,-0.074189045,0.04247299,0.016818577,-0.045221068,-0.058242224,-0.05771282,-0.04732951,0.089492634,0.06755716,0.08688146,0.00036111055,0.0005335886,0.0073355087,-0.0006657894,-0.006022846,0.058176637,0.00850572,-0.030104259,-0.059695657,0.0380847,0.015209995,-0.0055974266,0.031816382,0.028413277,0.07911349,-0.000457221,-0.033660606,0.010050397,-0.13959251,0.032295726,0.010398684,0.082277894,0.04179606,0.06918203,-0.07197024,0.005856258,0.10111039,-0.0716073,-0.0954468,0.02353688,0.011132268,-0.005413399,0.027181169,0.103758916,0.04144974,-0.06237323,-0.014760627,0.1468291,-0.01954289,-0.025724115,0.083258934,0.01232205,-0.033960816,0.010615103,-0.00057452463,-0.02667159,-0.068288684,0.019189639,0.08084088,-0.06612165,0.124962114,0.017023325,3.9040067e-33,0.012712297,0.020965012,-0.051613793,0.057155993,-0.01570208,-0.13273178,-0.038873013,-0.043924384,-0.13208526,-0.057936635,-0.028119933,-0.036076646,0.045167778,-0.0027432365,-0.04962797,0.06517838,-0.028996175,-0.008464323,0.0852413,0.013224132,-0.031030446,-0.0037527513,-0.08400206,0.05104233,0.02480599,0.08049226,-0.05474548,0.019079069,0.066552356,-0.040099896,0.011711009,-0.052330494,-0.11367896,0.012996513,0.038833715,-0.08354919,-0.009262933,-0.044864632,-0.001351521,0.027845738,-0.05636347,0.0065427595,0.04338981,-0.04424089,0.04178245,-0.00256542,-0.07206874,0.035563312,0.038572583,0.045670707,0.058198653,-0.06139153,0.069707334,-0.048180595,-0.09193562,-0.0278262,0.0018170038,-0.029326444,0.03163813,0.06993215,-0.06554339,0.059393063,-0.03350394,-0.019677576,-0.008725338,-0.04304419,-0.034849543,-0.026854176,0.042584058,0.050579462,-0.03314706,-0.029196229,-0.036009625,-0.011034058,0.043221798,-0.03037078,0.003662076,-0.009652269,-0.030433906,0.029793521,0.0065042265,-0.016788425,-0.0019610508,0.0059509557,-0.051513296,-0.03758667,-0.049076997,-0.095212296,-0.008192097,0.02084185,0.011565192,-0.044209316,-0.088066034,0.06313442,0.034802254,-6.318348e-33,0.11542709,-0.13879943,0.12712067,-0.08267854,-0.0956927,0.054853525,0.003404611,-0.015437918,0.06344374,-0.042816337,0.031377975,-0.07221058,0.033490434,-0.03803069,-0.007833351,0.0042073936,-0.035141,0.077358,-0.02526133,0.04459341,0.015808199,0.0904396,0.025624717,0.083394244,0.016342118,0.0088042,-0.00940294,-0.00681677,0.065545075,0.065298095,0.037790526,-0.0016614255,-0.0877195,-0.055997398,-0.03882443,0.016651636,-0.07920946,-0.042148143,-0.03277088,-0.0022028044,0.020925093,0.06525984,0.010158322,-0.007312191,-0.007106155,0.044273272,-0.033969052,0.032319807,-0.022284934,-0.008114152,-0.03632693,0.048605572,-0.06081325,0.05562481,0.0600971,-0.003957536,0.025889039,0.008449932,0.030901713,-0.082041815,-0.049906176,-0.030719453,-0.00011150245,0.016311279,-0.0048832837,0.060520783,-0.0531655,0.09118738,0.01542234,-0.01817731,0.07529021,-0.053630233,-0.0016840392,0.032329373,0.0021251529,-0.051970012,-0.067784,-0.011427347,0.046033945,0.03440809,-0.03594088,0.048655454,-0.027019184,-0.011571764,-0.013188546,-0.087254435,0.07066798,0.060162164,-0.06203311,0.033425994,0.0021321638,0.020346219,-0.071068965,0.040898815,-0.014064057,-5.9077042e-08,0.056486957,-0.009061303,0.036173806,-0.055160485,-0.027785517,0.029911704,-0.009242275,0.038409453,0.009290307,0.04621262,-0.057943605,0.07351004,0.068926044,-0.048205033,0.066845044,0.06260469,-0.073225416,-0.012044654,0.019547727,-0.008008349,-0.028989423,-0.04991473,-0.084177755,0.028352689,0.008749058,-0.022868445,0.02656575,0.08582646,0.044378005,0.0016077191,-0.05997205,0.020728419,-0.03112426,0.0017203501,0.01859529,-0.006449853,-0.04900499,-0.022266522,-0.04505251,0.0040719686,-0.0102698775,-0.08672871,-0.06651405,-0.002861913,-0.04627094,0.057799116,0.025016326,0.06353697,0.021476518,0.029090174,0.037452005,-0.06610827,-0.005220658,-0.049746566,-0.095396444,-0.011312718,-0.0011063275,0.0030573322,0.02183961,-0.03388443,0.02839163,0.031000761,0.110508665,-0.052379873 +2.10.1.1,"Catalyses the insertion of molybdenum into the ene-dithiol group of molybdopterin. In eukaryotes this reaction is catalysed by the N-terminal domain of a fusion protein whose C-terminal domain catalyses EC 2.7.7.75, molybdopterin adenylyltransferase. Requires divalent cations such as Mg2+ or Zn2+ for activity.",384,0.99999994,-0.06486588,-0.095152326,-0.038283367,0.017440377,0.045230735,-0.052101366,-0.031763002,-0.005425034,0.010126391,-0.02423131,0.030393688,-0.06122345,-0.004283443,0.022020072,-0.019662036,0.045127314,-0.06844741,0.032560993,-0.020200757,0.018247308,0.02971884,0.009832611,0.019656526,-0.0043075327,0.0152803175,0.02184512,-0.0015372935,-0.03217144,0.038137823,-0.054389752,0.052065074,-0.026927914,-0.04891277,-0.012747254,0.076554,0.08273219,-0.019567309,-0.020841446,0.048998144,-0.066619724,0.047687616,0.03450552,0.035326764,-0.08020128,-0.020797122,-0.008980998,0.0004917616,-0.0047315876,0.03113042,-0.0014039818,0.08233199,-0.06526396,-0.049547054,0.031188693,0.029395724,0.020600721,-0.108552225,0.05205243,0.11308554,0.025379801,0.021145813,0.05412596,0.07362288,0.027714316,0.08745844,-0.15202308,0.047144752,-0.0013774775,-0.052225754,-0.017678265,-0.03529004,-0.035526093,-0.002352442,-0.0015188088,0.011936769,0.03913681,-0.016185926,-0.028230531,-0.018683217,-0.012341219,0.07622587,0.07470428,0.06672559,0.063531786,0.06575415,-0.040685333,-0.032632012,0.00558116,0.027272027,0.027228385,0.034872893,-0.020373823,0.041531127,0.005128832,-0.039423876,0.007820548,0.06515967,0.031640276,-0.022578824,0.058052056,-0.034098092,0.07403634,-0.06488337,-0.086113535,-0.04459442,-0.022007374,0.013536096,0.06955263,0.01971957,0.024648756,0.009995318,0.009386176,0.09847781,-0.04843407,-0.004870261,-0.0054982286,-0.013901407,0.0065801153,0.017474689,-0.049031556,-0.012542219,-0.0055108536,0.0037502064,0.06142148,-0.088699654,0.081196174,-0.03486105,6.363454e-33,0.09629865,0.024418825,0.06303348,0.006909463,0.017685317,0.005444568,-0.041503705,0.014259224,-0.08251396,-0.067191035,-0.06613966,-0.0773557,0.06897604,0.012656968,-0.019673776,-0.037400953,-0.056546044,-0.006062816,0.025746295,0.037083782,-0.04043993,-0.0011779222,-0.018777648,0.02220006,0.04504463,0.051419742,-0.038852308,-0.020915251,0.08520103,0.0031835164,-0.03170576,-0.09055881,-0.12698226,0.004632129,0.030557353,-0.048739195,0.0005780147,-0.07325086,0.029057238,-0.003955073,-0.07923366,-0.0337779,-0.09146087,-0.07207224,0.018889403,0.039667487,0.049521588,0.07004531,-0.0019372428,-0.025565235,0.050716005,-0.06460107,0.018473696,-0.087222025,-0.065926164,-0.0045420774,-0.016074046,-0.039995946,0.05666344,0.10726408,-0.0030047684,0.028514275,0.013912236,0.0014611365,-0.026120896,-0.016643591,-0.093352735,-0.09040474,0.057660356,0.029813988,-0.09932624,0.02638709,0.0875219,0.0012668389,0.018218143,-0.050639294,-0.009680071,-0.06503317,0.01771565,0.041082017,-0.032894474,0.02394705,-0.007876975,-0.0881996,0.07555004,0.012833963,-0.1235103,-0.093606114,-0.048964195,0.054680433,-0.009706017,-0.040158223,-0.052991897,-0.0105532035,-0.019051133,-6.979008e-33,0.08192561,-0.050577533,0.023904392,-0.10755549,-0.10494735,0.025654431,-0.047094945,-0.045448296,0.06042361,-0.03440445,0.04133931,-0.002533496,0.09457084,-0.048480947,0.022784214,-0.039455276,-0.030957324,0.12701844,0.016665196,-0.043939043,0.069362625,0.0030580438,-0.041153137,0.041577663,0.056135107,0.060523972,-0.031410504,0.08176094,0.08781766,0.0484944,0.0011848706,-0.02624654,-0.100524135,0.018659549,-0.06408411,0.066014946,-0.053561617,-0.015549328,0.007883311,0.0012076809,-0.027150322,0.05432045,0.00014961847,0.09954929,0.009536305,0.053175505,-0.047587797,0.054717887,0.07451773,-0.02912973,0.033241753,-0.032806266,-0.018247757,-0.002511592,0.0012287069,0.03636984,0.031488393,0.005476168,0.024147063,-0.039233435,-0.004716411,-0.024896001,0.057696715,0.0075953673,-0.024574662,0.09121536,-0.021698002,0.06269839,0.07443907,-0.048315402,0.043903433,0.0049821213,-0.034263592,0.0043022963,0.032853156,0.041565187,-0.003832815,-0.063064486,0.009089126,-0.020514326,-0.016313234,0.041652113,0.02143028,-0.10213738,0.050020713,-0.01686384,0.048685875,0.11361849,-0.015334659,0.010680144,-0.05558573,-0.037447255,0.011636991,0.034029927,0.04055565,-4.1644245e-08,0.0005621475,-0.13704765,0.0037106066,-0.08400577,-0.027542083,0.089273,0.026346024,-0.02386384,-0.009299325,-0.081143275,0.06122522,0.015940588,0.013439104,-0.01911336,0.046660304,0.098902434,0.013182421,0.028648281,-0.035651173,-0.02695563,-0.015754383,-0.009935194,-0.06741321,0.12827365,-0.050378855,-0.04587507,0.0044298265,0.08782088,-0.072893,0.0035462854,0.027993482,-0.043365147,-0.03662907,0.00288096,-0.0146538215,0.004304673,-0.025632765,-0.040291037,-0.02529676,-0.051828098,-0.05008173,0.019137999,-0.008574321,-0.012087699,-0.059461825,0.032080013,-0.0016303032,0.103944376,-0.040362414,0.07196484,0.06733591,-0.07485794,-0.011164726,-0.037097722,-0.11300984,-0.011174534,-0.051062517,-0.076196864,-0.02000891,-0.050991382,-0.027068995,0.032630723,0.18120213,-0.046785515 +3.1.1.87,The enzyme is involved in degradation of fumonisin B1 [1]. 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+3.1.1.88,"The enzyme is involved in degradation of pyrethroid pesticides. The enzymes from Sphingobium sp., Klebsiella sp. and Aspergillus niger hydrolyse cis-permethrin at approximately equal rate to trans-permethrin [1-3]. The enzyme from mouse hydrolyses trans-permethrin at a rate about 22-fold higher than cis-permethrin [4]. 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+3.1.3.85,"The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. In vivo the enzyme catalyses the dephosphorylation of 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate with lower efficiency [1,2]. Divalent metal ions (Mg2+, Mn2+ or Co2+) stimulate activity [1,2].",384,1.0,0.036265396,-0.04718922,-0.07542448,0.02832739,0.04368297,-0.05029537,-0.0069680284,0.0040957765,0.035674352,0.06968774,-0.020916907,0.04288972,-0.04364882,-0.007239911,-0.030492177,-0.01751057,0.0120327575,0.026932867,-0.06829302,0.029593144,0.1772713,-0.060119107,-0.00086935976,-0.014646579,0.06194024,-0.0121478485,0.051173218,-0.06405273,-0.05451878,-0.05014077,-0.042809725,-0.10990727,0.06409372,-0.015543136,0.05182968,0.045940366,0.013038829,0.012277221,-0.057839796,-0.017054448,0.022403954,0.0067199934,0.029624317,0.0013650961,-0.054235797,-0.05060336,-0.039854966,0.022852095,0.008865742,0.052818883,-0.042798243,-0.057090554,-0.06255824,0.030290708,-0.0372547,0.058238506,-0.06634434,0.06889198,-0.005728467,-0.023492303,-0.027704941,0.00022863591,0.051412158,0.023857988,0.058277555,-0.070920475,0.033679422,-0.09094712,-0.062335014,-0.023862284,-0.027381977,-0.060722403,-0.016441552,-0.044224832,0.059048407,0.065960124,0.06831265,-0.020387283,0.04993559,-0.04330269,0.12513939,0.047088746,0.07549736,0.019280972,-0.040997457,0.06555502,-0.013515483,0.031020623,0.055025678,0.0049501583,0.029714698,-0.04301452,-0.0067896694,-0.0067550344,0.009384394,0.04267381,0.024240006,0.07101516,0.04126739,-0.00014659505,-0.01954088,0.11330894,0.0021325382,-0.04285274,-0.027195822,0.04979307,-0.017982624,0.055023428,0.015259437,0.03206394,0.038412802,0.04547291,0.02635023,0.095559865,-0.075843066,0.081023686,0.015975794,-0.078796454,-0.03457858,0.019939924,0.062332604,-0.026313182,0.019313408,0.022927683,-0.03387443,0.07720856,-0.01693812,3.6945387e-33,0.022755029,0.050256763,0.055316117,-0.028955225,-0.0035168903,-0.044646174,-0.06779347,-0.041053124,-0.041639816,0.06601047,-0.084002405,-0.060619242,0.05642337,0.07855072,-0.00710565,0.0193645,0.036011077,0.011793799,0.10988969,0.0018235497,0.04088493,0.05984796,-0.03194202,0.0041995216,0.06759366,0.12064129,-0.06952902,0.031241013,0.06284719,-0.008535686,0.05006828,-0.06637703,-0.023642052,0.038293723,-0.003153201,-0.073904544,-0.0715691,-0.06065109,0.042354316,0.0069133625,-0.022909412,-0.021670844,-0.061475858,0.015560601,0.0023426285,-0.0457372,-0.028046632,0.041836057,0.02217908,0.083850294,0.020515243,-0.0032105453,0.0653929,0.072513744,-0.06667879,-0.007928043,-0.07501395,-0.090252176,0.11423483,0.067942165,-0.024300274,0.060126342,0.03488792,0.04285376,0.017929351,-0.023662807,-0.06644023,-0.036709096,-0.041637734,0.061858222,-0.032852553,-0.0851093,0.041951187,0.0041716816,-0.013020599,-0.080015264,0.08313327,-0.035126198,-0.014491506,-0.03687138,0.007822152,0.014343495,-0.034664325,0.032458775,-0.05886393,0.03408057,-0.080955006,-0.09720921,-0.030316213,0.052415147,-0.052772097,0.01870372,-0.10937366,0.029490776,-0.01826026,-5.1540487e-33,0.12471825,-0.07798173,0.07048996,-0.08544665,-0.07384613,0.011616759,-0.0077487454,-0.09229455,0.0595772,-0.049543496,0.022878597,0.015074433,-0.008735931,-0.057607282,0.01684714,-0.019000022,-0.00069971744,0.07240154,-0.002114234,0.021831684,0.062019274,0.07188197,-0.026697215,0.0060109794,0.08387635,-0.04433502,0.04953973,0.042290833,0.014005824,0.06807978,0.025965817,0.042922836,0.013269137,-0.03869158,-0.030457927,0.082184225,-0.047671687,-0.03136142,-0.019586721,0.044588532,-0.061097637,0.06315833,0.05461003,-0.029503034,0.07930343,0.06830763,-0.07450788,0.05541028,-0.00156623,-0.025615899,0.02700056,0.0062765945,-0.06998637,0.056392714,0.059298683,0.059174713,0.018820306,-0.009408495,-0.009884806,-0.057097234,-0.03898197,-0.050313834,0.021828612,-0.052362133,0.065208636,0.027827956,0.0063178013,0.003926107,-0.00516746,0.113167785,-0.01810697,-0.014158716,-0.027577834,0.03937477,-0.012116632,-0.0023860324,-0.09525075,-0.04603621,0.006907434,-0.035113152,-0.02455202,0.051961713,0.069077626,-0.03858396,-0.0070641884,-0.078811765,-2.0199484e-06,0.1702874,-0.032433383,0.02459966,-0.080191016,-0.112624004,-0.031108422,0.008372206,0.03999926,-5.3201855e-08,0.03860369,-0.054081976,0.030662356,-0.07170597,-0.020393312,0.045537956,0.017392384,-0.0019694583,0.020282298,-0.04793258,-0.0064515397,0.058796223,0.022642283,-0.050340828,-0.00680382,0.051387083,-0.04299872,0.02905466,-0.03694743,-0.00018702532,-0.07643151,-0.029153993,-0.13249259,0.01209936,0.017936023,-0.0656481,0.04985018,0.040818706,-0.09732247,0.022573913,0.0008987322,0.012796918,0.045470245,-0.058256302,-0.056281533,-0.052041136,-0.06028138,-0.0155871,-0.0053016413,-0.05114005,-0.05359516,-0.04526776,0.06659598,0.020107986,-0.055577006,0.0012653838,-0.019404415,-0.005112406,0.0015690515,-0.0048903646,0.015417165,-0.043805256,-0.09500639,-0.09545081,-0.048672184,-0.033113647,-0.036543462,-0.04410365,0.002652084,-0.032822978,0.046799652,0.008217461,0.083106235,-0.0878001 +3.2.1.171,The enzyme is part of the degradation system for rhamnogalacturonan I in Aspergillus aculeatus. ,384,0.99999994,-0.017202135,-0.0023571618,-0.102026895,-0.008414828,0.11070567,0.0069691334,-0.050435945,0.04904379,-0.00073009863,-0.050864812,0.030610804,0.034409862,-0.03452473,0.06460246,-0.1299553,0.077796295,0.014537805,0.048931148,-0.02825726,-0.0361092,0.064162076,0.05343105,-0.021093607,0.009068532,0.031773146,-0.005696548,0.01629498,-0.030301306,-0.061874766,-0.067513674,0.0034125287,-0.03350748,0.048056398,-0.04346163,0.024821904,0.12984733,-0.05635829,-0.07269549,0.125984,0.038461316,-0.008290599,0.009415473,0.022667268,-0.027212398,-0.042802908,-0.015906284,-0.12668172,0.047128517,0.04228295,-0.026354397,-0.059253804,-0.041323382,0.03082992,0.021746011,0.06082279,0.012424604,-0.10024422,-0.060577184,-0.12226133,0.03694674,0.07241745,0.027192133,-0.041333523,-0.027426058,-0.044880245,0.010189788,0.021013558,-0.05293724,0.0038724483,0.042000614,-0.030801773,-0.0551291,-0.014937074,-0.05994336,0.034916874,-0.033927653,0.008621747,-0.056658838,0.01982468,-0.013438323,0.043718938,0.044385117,0.048303433,-0.032953944,0.023604155,-0.025411109,0.031522706,0.036538094,-0.026646502,0.01639409,0.041425977,0.018494956,0.007692664,-0.019167483,-0.039946564,-0.0021367378,0.025761675,0.03477432,0.019581793,-0.032410122,-0.05510077,-0.020958826,0.03886855,-0.08847689,-0.046804562,0.006791106,-0.032277495,0.08546078,0.071834356,-0.019147487,-0.00179274,-0.0074067763,-0.034273673,-0.013674949,0.012851938,0.039973702,-0.011319845,0.018920353,-0.09304183,0.023720335,0.0048426385,0.021121576,-0.016793257,-0.02867059,0.0111749265,0.012696057,-0.05893399,1.00169935e-33,-0.022280138,-0.049022067,-0.09542715,-0.06340312,0.042409148,-0.033562616,-0.018363593,0.005333864,0.06320061,-0.0678571,-0.035810534,-0.060236957,-0.1064432,0.027653143,-0.017631015,0.030187925,0.03425598,-0.053676274,0.0012563565,0.01256761,0.009205662,0.030519744,-0.06451131,-0.007882408,-0.00201743,0.040642593,0.025344754,0.013683902,-0.024511648,-0.02470928,0.077516444,-0.01808744,-0.1671394,0.040384766,0.068949245,0.035974987,0.019349502,-0.013313765,-0.04817226,0.0038858918,-0.030207086,0.022315852,-0.026314398,-0.03905338,0.031552657,-0.04943254,-0.037706986,0.12724897,0.113199815,0.05800219,0.04973253,0.013747243,0.11364787,-0.008963795,-0.010879272,-0.010428985,-0.0209513,0.047835227,0.030061582,-0.013692338,-0.061412983,-0.03226312,-0.00629531,0.0096359365,0.018492172,0.019495403,-0.032486413,-0.058390833,0.049517013,0.0032898067,-0.039019614,0.005352446,-0.02422449,0.027829671,0.024452701,-0.075144984,-0.022546746,0.02985933,0.0014190965,0.014851795,-0.025542054,0.02321763,0.029308585,-0.037022226,-0.038353402,0.015272554,0.047380257,-0.0012424464,0.0809841,0.02227754,0.00953876,-0.07047983,-0.055588923,0.0645794,0.08666484,-2.5887233e-33,0.11457554,-0.10035484,0.02635113,0.03935529,-0.09439905,0.07515387,0.0061046467,0.12296877,-0.027850196,-0.02206105,0.03386459,0.040104806,-0.01415796,0.04790931,0.08273557,0.04450068,-0.037713163,0.0598183,0.02602783,-0.0420092,-0.10835711,0.1328905,-0.009589015,0.023906864,0.027739367,0.026031917,-0.03938171,0.04828333,0.014161006,-0.0067129936,-0.014110413,-0.0017459595,-0.050117545,-0.01846967,-0.06838324,0.095545344,-0.002919446,0.017663626,-0.04597713,0.08072775,0.053408146,0.02962363,-0.018497406,0.041564498,0.018132383,0.038794085,-0.07054042,0.014407632,-0.022422472,-0.09239745,0.015003927,0.031694643,0.018627299,-0.03578487,0.021684472,0.04111467,0.022174593,0.01440086,0.010549019,-0.042130727,-0.0927225,-0.07033799,0.012334957,0.045278847,0.06390655,0.03284514,0.00207229,0.027256696,0.104920216,-0.0076313545,0.05568912,0.075683445,0.042132262,0.032759532,0.011750692,-0.07804071,-0.07503032,0.009064581,-0.006414774,-0.020632807,0.08035057,-0.053219274,-0.0008726323,-0.064856626,-0.06174994,-0.07810084,0.08809991,0.071527,-0.076054,-0.025830017,0.043999124,-0.018880798,-0.13418195,0.030196669,0.08821997,-2.4787411e-08,0.07607232,0.043823928,0.052224185,-0.08113516,0.07555911,-0.002833078,0.06436868,0.04877064,0.05552172,0.04149387,-0.08300511,0.054531813,-0.028290335,0.009377452,-0.017458998,-0.042422723,-0.063926466,0.0441521,0.02325436,0.084371716,-0.057932064,-0.04478838,-0.09814454,0.029015465,0.0011678295,-0.036237594,0.08932,0.052208934,-0.02262661,0.042610366,-0.0079419995,0.06610094,0.049633373,0.019572003,-0.087045245,-0.013310441,-0.016371274,-0.066449955,-0.014007937,0.010456461,-0.048206285,-0.00052253646,-0.0410986,-0.0314723,-0.043078624,-0.081466906,0.011507132,-0.023117092,-0.007136018,-0.022663852,0.033713326,-0.045856256,-0.027372153,-0.054492723,-0.06709413,-0.04121781,0.067700185,-0.0071923127,-0.09522523,-0.08039305,-0.01976971,0.006020699,0.15697289,-0.055801738 +3.2.1.172,The enzyme is part of the degradation system for rhamnogalacturonan I in Bacillus subtilis strain 168. 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+3.2.1.173,The enzyme is part of the degradation system for rhamnogalacturonan I in Aspergillus aculeatus. ,384,0.99999994,-0.017202135,-0.0023571618,-0.102026895,-0.008414828,0.11070567,0.0069691334,-0.050435945,0.04904379,-0.00073009863,-0.050864812,0.030610804,0.034409862,-0.03452473,0.06460246,-0.1299553,0.077796295,0.014537805,0.048931148,-0.02825726,-0.0361092,0.064162076,0.05343105,-0.021093607,0.009068532,0.031773146,-0.005696548,0.01629498,-0.030301306,-0.061874766,-0.067513674,0.0034125287,-0.03350748,0.048056398,-0.04346163,0.024821904,0.12984733,-0.05635829,-0.07269549,0.125984,0.038461316,-0.008290599,0.009415473,0.022667268,-0.027212398,-0.042802908,-0.015906284,-0.12668172,0.047128517,0.04228295,-0.026354397,-0.059253804,-0.041323382,0.03082992,0.021746011,0.06082279,0.012424604,-0.10024422,-0.060577184,-0.12226133,0.03694674,0.07241745,0.027192133,-0.041333523,-0.027426058,-0.044880245,0.010189788,0.021013558,-0.05293724,0.0038724483,0.042000614,-0.030801773,-0.0551291,-0.014937074,-0.05994336,0.034916874,-0.033927653,0.008621747,-0.056658838,0.01982468,-0.013438323,0.043718938,0.044385117,0.048303433,-0.032953944,0.023604155,-0.025411109,0.031522706,0.036538094,-0.026646502,0.01639409,0.041425977,0.018494956,0.007692664,-0.019167483,-0.039946564,-0.0021367378,0.025761675,0.03477432,0.019581793,-0.032410122,-0.05510077,-0.020958826,0.03886855,-0.08847689,-0.046804562,0.006791106,-0.032277495,0.08546078,0.071834356,-0.019147487,-0.00179274,-0.0074067763,-0.034273673,-0.013674949,0.012851938,0.039973702,-0.011319845,0.018920353,-0.09304183,0.023720335,0.0048426385,0.021121576,-0.016793257,-0.02867059,0.0111749265,0.012696057,-0.05893399,1.00169935e-33,-0.022280138,-0.049022067,-0.09542715,-0.06340312,0.042409148,-0.033562616,-0.018363593,0.005333864,0.06320061,-0.0678571,-0.035810534,-0.060236957,-0.1064432,0.027653143,-0.017631015,0.030187925,0.03425598,-0.053676274,0.0012563565,0.01256761,0.009205662,0.030519744,-0.06451131,-0.007882408,-0.00201743,0.040642593,0.025344754,0.013683902,-0.024511648,-0.02470928,0.077516444,-0.01808744,-0.1671394,0.040384766,0.068949245,0.035974987,0.019349502,-0.013313765,-0.04817226,0.0038858918,-0.030207086,0.022315852,-0.026314398,-0.03905338,0.031552657,-0.04943254,-0.037706986,0.12724897,0.113199815,0.05800219,0.04973253,0.013747243,0.11364787,-0.008963795,-0.010879272,-0.010428985,-0.0209513,0.047835227,0.030061582,-0.013692338,-0.061412983,-0.03226312,-0.00629531,0.0096359365,0.018492172,0.019495403,-0.032486413,-0.058390833,0.049517013,0.0032898067,-0.039019614,0.005352446,-0.02422449,0.027829671,0.024452701,-0.075144984,-0.022546746,0.02985933,0.0014190965,0.014851795,-0.025542054,0.02321763,0.029308585,-0.037022226,-0.038353402,0.015272554,0.047380257,-0.0012424464,0.0809841,0.02227754,0.00953876,-0.07047983,-0.055588923,0.0645794,0.08666484,-2.5887233e-33,0.11457554,-0.10035484,0.02635113,0.03935529,-0.09439905,0.07515387,0.0061046467,0.12296877,-0.027850196,-0.02206105,0.03386459,0.040104806,-0.01415796,0.04790931,0.08273557,0.04450068,-0.037713163,0.0598183,0.02602783,-0.0420092,-0.10835711,0.1328905,-0.009589015,0.023906864,0.027739367,0.026031917,-0.03938171,0.04828333,0.014161006,-0.0067129936,-0.014110413,-0.0017459595,-0.050117545,-0.01846967,-0.06838324,0.095545344,-0.002919446,0.017663626,-0.04597713,0.08072775,0.053408146,0.02962363,-0.018497406,0.041564498,0.018132383,0.038794085,-0.07054042,0.014407632,-0.022422472,-0.09239745,0.015003927,0.031694643,0.018627299,-0.03578487,0.021684472,0.04111467,0.022174593,0.01440086,0.010549019,-0.042130727,-0.0927225,-0.07033799,0.012334957,0.045278847,0.06390655,0.03284514,0.00207229,0.027256696,0.104920216,-0.0076313545,0.05568912,0.075683445,0.042132262,0.032759532,0.011750692,-0.07804071,-0.07503032,0.009064581,-0.006414774,-0.020632807,0.08035057,-0.053219274,-0.0008726323,-0.064856626,-0.06174994,-0.07810084,0.08809991,0.071527,-0.076054,-0.025830017,0.043999124,-0.018880798,-0.13418195,0.030196669,0.08821997,-2.4787411e-08,0.07607232,0.043823928,0.052224185,-0.08113516,0.07555911,-0.002833078,0.06436868,0.04877064,0.05552172,0.04149387,-0.08300511,0.054531813,-0.028290335,0.009377452,-0.017458998,-0.042422723,-0.063926466,0.0441521,0.02325436,0.084371716,-0.057932064,-0.04478838,-0.09814454,0.029015465,0.0011678295,-0.036237594,0.08932,0.052208934,-0.02262661,0.042610366,-0.0079419995,0.06610094,0.049633373,0.019572003,-0.087045245,-0.013310441,-0.016371274,-0.066449955,-0.014007937,0.010456461,-0.048206285,-0.00052253646,-0.0410986,-0.0314723,-0.043078624,-0.081466906,0.011507132,-0.023117092,-0.007136018,-0.022663852,0.033713326,-0.045856256,-0.027372153,-0.054492723,-0.06709413,-0.04121781,0.067700185,-0.0071923127,-0.09522523,-0.08039305,-0.01976971,0.006020699,0.15697289,-0.055801738 +3.2.1.174,The enzyme is part of the degradation system for rhamnogalacturonan I in Aspergillus aculeatus.,384,0.99999994,-0.017202135,-0.0023571618,-0.102026895,-0.008414828,0.11070567,0.0069691334,-0.050435945,0.04904379,-0.00073009863,-0.050864812,0.030610804,0.034409862,-0.03452473,0.06460246,-0.1299553,0.077796295,0.014537805,0.048931148,-0.02825726,-0.0361092,0.064162076,0.05343105,-0.021093607,0.009068532,0.031773146,-0.005696548,0.01629498,-0.030301306,-0.061874766,-0.067513674,0.0034125287,-0.03350748,0.048056398,-0.04346163,0.024821904,0.12984733,-0.05635829,-0.07269549,0.125984,0.038461316,-0.008290599,0.009415473,0.022667268,-0.027212398,-0.042802908,-0.015906284,-0.12668172,0.047128517,0.04228295,-0.026354397,-0.059253804,-0.041323382,0.03082992,0.021746011,0.06082279,0.012424604,-0.10024422,-0.060577184,-0.12226133,0.03694674,0.07241745,0.027192133,-0.041333523,-0.027426058,-0.044880245,0.010189788,0.021013558,-0.05293724,0.0038724483,0.042000614,-0.030801773,-0.0551291,-0.014937074,-0.05994336,0.034916874,-0.033927653,0.008621747,-0.056658838,0.01982468,-0.013438323,0.043718938,0.044385117,0.048303433,-0.032953944,0.023604155,-0.025411109,0.031522706,0.036538094,-0.026646502,0.01639409,0.041425977,0.018494956,0.007692664,-0.019167483,-0.039946564,-0.0021367378,0.025761675,0.03477432,0.019581793,-0.032410122,-0.05510077,-0.020958826,0.03886855,-0.08847689,-0.046804562,0.006791106,-0.032277495,0.08546078,0.071834356,-0.019147487,-0.00179274,-0.0074067763,-0.034273673,-0.013674949,0.012851938,0.039973702,-0.011319845,0.018920353,-0.09304183,0.023720335,0.0048426385,0.021121576,-0.016793257,-0.02867059,0.0111749265,0.012696057,-0.05893399,1.00169935e-33,-0.022280138,-0.049022067,-0.09542715,-0.06340312,0.042409148,-0.033562616,-0.018363593,0.005333864,0.06320061,-0.0678571,-0.035810534,-0.060236957,-0.1064432,0.027653143,-0.017631015,0.030187925,0.03425598,-0.053676274,0.0012563565,0.01256761,0.009205662,0.030519744,-0.06451131,-0.007882408,-0.00201743,0.040642593,0.025344754,0.013683902,-0.024511648,-0.02470928,0.077516444,-0.01808744,-0.1671394,0.040384766,0.068949245,0.035974987,0.019349502,-0.013313765,-0.04817226,0.0038858918,-0.030207086,0.022315852,-0.026314398,-0.03905338,0.031552657,-0.04943254,-0.037706986,0.12724897,0.113199815,0.05800219,0.04973253,0.013747243,0.11364787,-0.008963795,-0.010879272,-0.010428985,-0.0209513,0.047835227,0.030061582,-0.013692338,-0.061412983,-0.03226312,-0.00629531,0.0096359365,0.018492172,0.019495403,-0.032486413,-0.058390833,0.049517013,0.0032898067,-0.039019614,0.005352446,-0.02422449,0.027829671,0.024452701,-0.075144984,-0.022546746,0.02985933,0.0014190965,0.014851795,-0.025542054,0.02321763,0.029308585,-0.037022226,-0.038353402,0.015272554,0.047380257,-0.0012424464,0.0809841,0.02227754,0.00953876,-0.07047983,-0.055588923,0.0645794,0.08666484,-2.5887233e-33,0.11457554,-0.10035484,0.02635113,0.03935529,-0.09439905,0.07515387,0.0061046467,0.12296877,-0.027850196,-0.02206105,0.03386459,0.040104806,-0.01415796,0.04790931,0.08273557,0.04450068,-0.037713163,0.0598183,0.02602783,-0.0420092,-0.10835711,0.1328905,-0.009589015,0.023906864,0.027739367,0.026031917,-0.03938171,0.04828333,0.014161006,-0.0067129936,-0.014110413,-0.0017459595,-0.050117545,-0.01846967,-0.06838324,0.095545344,-0.002919446,0.017663626,-0.04597713,0.08072775,0.053408146,0.02962363,-0.018497406,0.041564498,0.018132383,0.038794085,-0.07054042,0.014407632,-0.022422472,-0.09239745,0.015003927,0.031694643,0.018627299,-0.03578487,0.021684472,0.04111467,0.022174593,0.01440086,0.010549019,-0.042130727,-0.0927225,-0.07033799,0.012334957,0.045278847,0.06390655,0.03284514,0.00207229,0.027256696,0.104920216,-0.0076313545,0.05568912,0.075683445,0.042132262,0.032759532,0.011750692,-0.07804071,-0.07503032,0.009064581,-0.006414774,-0.020632807,0.08035057,-0.053219274,-0.0008726323,-0.064856626,-0.06174994,-0.07810084,0.08809991,0.071527,-0.076054,-0.025830017,0.043999124,-0.018880798,-0.13418195,0.030196669,0.08821997,-2.4787411e-08,0.07607232,0.043823928,0.052224185,-0.08113516,0.07555911,-0.002833078,0.06436868,0.04877064,0.05552172,0.04149387,-0.08300511,0.054531813,-0.028290335,0.009377452,-0.017458998,-0.042422723,-0.063926466,0.0441521,0.02325436,0.084371716,-0.057932064,-0.04478838,-0.09814454,0.029015465,0.0011678295,-0.036237594,0.08932,0.052208934,-0.02262661,0.042610366,-0.0079419995,0.06610094,0.049633373,0.019572003,-0.087045245,-0.013310441,-0.016371274,-0.066449955,-0.014007937,0.010456461,-0.048206285,-0.00052253646,-0.0410986,-0.0314723,-0.043078624,-0.081466906,0.011507132,-0.023117092,-0.007136018,-0.022663852,0.033713326,-0.045856256,-0.027372153,-0.054492723,-0.06709413,-0.04121781,0.067700185,-0.0071923127,-0.09522523,-0.08039305,-0.01976971,0.006020699,0.15697289,-0.055801738 +3.2.1.175,"The enzyme hydrolzes the biologically inactive beta-D-glucopyranosyl ester of abscisic acid to produce active abscisate. Abscisate is a phytohormone critical for plant growth, development and adaption to various stress conditions. The enzyme does not hydrolyse beta-D-glucopyranosyl zeatin [1]. ",384,1.0,-0.07499615,-0.09906997,-0.087815985,0.019405764,0.060295835,0.010689351,-0.03724306,0.037184533,0.015028675,-0.005313488,0.10447754,0.038031954,-0.05385849,-0.022687897,-0.11866633,0.04201052,0.023660472,0.01580431,-0.077608734,-0.070438184,0.015988147,0.022314416,-0.0077512725,0.031004803,0.07476664,-0.057207834,-0.06353631,0.024792278,0.0676797,-0.086501725,-0.05535669,-0.011786572,0.10370823,0.002751783,0.037437703,0.034036588,-0.019203866,-0.031266507,0.06410015,0.01405802,0.055406008,-0.028934224,-0.046433624,-0.038549125,-0.08358878,0.015507304,-0.032898486,-0.009057661,0.04021504,-0.05806832,-0.0035061855,-0.08324752,0.0008960434,0.0020669727,-0.09394384,-0.0023849572,-0.057012092,0.038431585,0.05677796,0.08473842,0.030302294,0.010808134,0.023869153,-0.0030114178,-0.0061075105,-0.02380303,-0.075733155,-0.015702303,-0.019165155,0.006280525,0.057725295,-0.08802336,-0.03256033,-0.011909452,-0.027671233,-0.026057035,-0.022348093,-0.017445035,0.042605355,0.02769406,0.0561182,-0.03237772,0.03533481,0.022259744,0.020935336,-0.024921587,0.03887912,0.08103289,0.010795331,0.037724197,0.023346508,-0.035671502,-0.06502477,-0.0016374467,-0.04721362,0.05352185,0.05107349,-0.09893016,-0.076375864,-0.026676146,-0.05477452,0.058140855,0.008153731,-0.04265939,-0.026712168,-0.00924572,-0.03151785,0.012010705,0.02974889,0.018530246,-0.098620854,0.022152653,0.018838778,0.06204117,-0.07435944,0.031542074,0.03628815,-0.060778607,-0.020897182,-0.042987708,0.051794615,0.004333626,0.06137686,0.0818661,-0.0023910743,0.02906352,-0.030443195,3.746232e-33,0.013606051,0.018898189,-0.080078185,-0.027327543,-0.036176074,-0.027424062,-0.10843507,0.019840851,-0.02869471,-0.059562266,-0.022899106,-0.060410276,0.015578135,0.09443124,0.00093657593,0.022453627,0.085622124,-0.0406262,0.050229736,0.01735346,-0.0026365276,-0.0034240857,-0.12817988,0.007061309,0.018599726,0.003740677,-0.035208438,0.074560896,0.026589252,-0.0076678474,0.033982646,-0.051107656,-0.02821426,0.056732204,-0.015629916,0.046777,-0.010132658,-0.077062555,0.013350973,0.014773648,-0.014251927,0.034166418,-0.015552267,-0.0714982,0.08876854,0.018574001,-0.007738514,0.05060651,0.034023266,0.059927046,0.052279305,0.06996075,0.057257853,0.0057521416,-0.001067162,0.05434857,-0.07080906,-0.017352069,0.03290999,0.027324261,-0.060444538,-0.0058394354,-0.053709686,0.053486183,-0.028282687,0.006337852,-0.12926044,-0.029255882,0.014101323,0.05225851,-0.0773787,-0.070960715,0.047640193,0.0256308,-0.037469238,-0.062423162,0.030078288,-0.026500085,-0.013143423,0.062006313,0.029991847,0.0079343505,0.027279414,0.008434813,-0.04941613,0.012477488,-0.005970581,-0.0022218628,0.010130073,0.0020181956,0.0072706556,-0.0462332,-0.0672716,0.09766445,0.0109324,-3.895007e-33,0.11941866,-0.067906745,0.05831221,-0.027811354,-0.021706307,0.060247544,-0.024753174,-0.052406717,0.015721086,-0.050825436,0.008129775,0.022160573,-0.07243831,-0.02404163,0.006719904,0.0056019,-0.045321092,0.02246729,-0.0276097,0.03677814,-0.047213912,0.13438077,0.068936996,-0.02284258,0.020881658,-0.011467803,-0.0040724482,0.09177011,-0.03973334,0.073772416,0.0029160765,-0.0006593113,-0.009127491,-0.035817664,0.013416199,0.04984086,-0.029051784,0.0030134548,-0.05083762,0.013621437,-0.010703001,0.080315515,-0.094902046,0.004546266,0.070974275,0.11238284,0.024076816,0.004124299,-0.02074351,-0.03573353,0.042334165,0.030350152,0.004072366,0.10789352,0.07427486,-0.050770096,-0.012200789,0.019407146,-0.08345864,-0.018037422,0.016729297,-0.044384435,0.024869142,-0.059019256,0.032385334,0.049712826,0.010097174,0.13375352,-0.038007148,0.09721087,0.0962035,0.04043443,0.022936959,0.07042881,-0.0018788227,0.042134292,-0.053156223,-0.10586687,-0.0948497,-0.073473975,-0.035521455,0.06343452,-0.059928507,-0.041804675,-0.053704668,-0.04617778,-0.047560893,0.11986183,0.010552758,0.02692398,-0.029999077,-0.051559605,0.0010601144,0.060589463,0.12795395,-3.6900584e-08,-0.0012123878,0.00072101987,0.012718991,-0.084252305,0.05474434,-0.018830681,0.00038156033,-0.04746949,-0.0031950646,-0.01841968,-0.14154014,0.044200025,-0.009275822,0.03885357,-0.04047771,0.031116426,0.031547308,0.055747233,0.013939433,0.08310112,-0.06402847,0.048145536,-0.07464839,-0.0017755833,-0.044440113,-0.09132599,0.054281544,0.03567394,-0.023999292,0.054927956,0.037246544,0.094583325,0.12970144,-0.0413113,-0.03707661,0.059477568,0.0034872503,-0.0239663,-0.094857804,0.0024806715,0.05074013,-0.027006319,0.033544675,-0.036149316,-0.05863161,-0.02599624,-0.0055265212,-0.012214271,0.06261207,0.01160899,0.10662889,-0.05062973,-0.002620114,-0.033388022,-0.029339688,-0.013695894,-0.031804238,-0.047436457,-0.0062201964,-0.028723335,-0.0077533573,-0.013657882,0.15067208,-0.044657923 +3.4.11.25,Sphingosinicella xenopeptidilytica strain 3-2W4 is able to utilize the beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu as sole carbon and energy sources [2]. ,384,1.0,-0.03643646,-0.07914007,-0.09189827,-0.02069672,0.06954326,0.045947496,0.018642249,0.026700245,-0.0041478756,-0.025000338,0.06871067,-0.05874217,-0.1311522,0.09271395,0.08668815,0.10263689,-0.013138248,0.034567125,0.0666242,0.016373577,0.016102813,-0.01590499,-0.028080683,0.04994771,-0.010999496,0.011594405,-0.047341138,0.004398618,-0.013374403,0.041773897,-0.039547615,0.0110697355,-0.021700313,-0.04917826,0.07723108,0.062287062,-0.05743286,-0.081734896,0.08473916,0.032784622,-0.016284967,0.017626397,0.060552113,-0.0015627416,-0.07189376,0.007285189,-0.01806381,0.08237455,0.03355024,-0.061141267,-0.048398864,-0.07987916,0.050278377,-0.006802151,-0.04494556,0.043533724,-0.10784084,0.0039626993,-0.01670759,-0.002097949,0.02846981,-0.008575582,0.037403677,-0.003978231,-0.012161663,-0.055871565,-0.026566353,-0.057761457,0.0053973673,0.027127257,-0.01899196,-0.048328422,0.0018247259,0.024769364,0.019062001,0.04041203,0.069315955,0.018092193,0.09638146,-0.042139404,-0.009585742,0.04816231,0.037627157,0.060230535,-0.0148931695,0.022286814,0.015091636,0.060385723,-0.015907265,0.06244217,0.0308393,-0.013512755,0.043591376,-0.0041505597,-0.044141583,0.032327536,0.058456205,-0.011089048,-0.018037498,0.01425583,-0.02264195,0.033973936,-0.0061478834,-0.044914775,0.030752625,-0.016467044,0.001372375,0.12001591,0.023436897,0.07073953,0.04433849,0.01790465,0.022319311,-0.047946997,-0.035433553,-0.010346574,0.005289516,-0.009578282,-0.08086512,0.0058831773,0.005082585,-0.12621005,-0.040049292,0.011322838,-0.061589725,-0.009473484,-0.047254927,8.9921975e-34,0.05667888,0.0151823,0.07968662,0.0008171481,-0.023170216,-0.07015015,-0.05179205,-0.055424392,-0.036848836,0.012400225,-0.11338109,-0.04662346,-0.010587058,0.09562467,-0.044609,-0.02436361,-0.056620125,0.034634475,0.112499155,0.0834799,-0.015909135,-0.0047108075,0.052688397,-0.06397236,0.13564752,-0.0059712245,-0.054715876,-0.019008683,0.000913593,-0.017505988,0.04964323,-0.0063267797,-0.11457306,0.039283562,0.013314737,-0.049859997,0.0017184422,-0.09843422,-0.033200175,0.004371839,0.049082596,0.09795901,0.032953814,-0.05546783,0.05672399,0.06455629,0.024115646,0.0033800167,-0.0035405639,0.008768949,0.028316071,0.0030920594,0.0819956,0.08117608,0.035979446,-0.020008951,0.015090737,-0.015201003,0.025569407,-0.013348477,-0.058773145,0.038320415,0.023677766,-0.03909091,0.049019363,0.021811882,-0.07303587,-0.04994379,-0.05007533,-0.061351947,-0.028173152,-0.047504187,0.038541082,-0.08120621,-0.02875518,-0.045422558,-0.044761542,-0.029964102,0.0054960386,0.008236176,-0.021600625,-0.03694342,0.022965156,-0.012709511,-0.09696337,0.04271882,0.05876701,0.020568768,0.10005392,-0.05001482,0.028338132,-0.03155027,-0.034429226,-0.001154344,-0.018138284,-9.986537e-34,-0.008680778,-0.06833953,-0.03622455,-0.064777605,-0.035063386,0.005430854,-0.057184923,-0.06571601,0.0030307455,0.028160619,0.061565544,0.036999937,-0.096072644,-0.053191427,-0.0061989874,0.04796989,-0.0384583,-0.015515037,0.005857788,-0.012044467,-0.008308523,0.063724115,0.0037853539,0.060311172,0.0034882904,0.0059932237,0.038015608,0.037332933,0.063356996,-0.015649492,-0.03947262,0.040716212,-0.013306868,-0.027056491,0.03322191,-0.07536596,-0.03333478,0.12601002,0.04452222,-0.0037524675,0.044247873,0.05916503,-0.02436581,0.13077569,0.09967038,0.115573995,-0.017064422,-0.011121546,-0.050593983,0.03308238,0.008113181,-0.11106683,-0.017087108,-0.03146408,0.03791566,-0.037765857,-0.0733132,0.058910433,-0.027705446,-0.05519853,-0.05100048,-0.029292895,0.01331281,0.019453483,0.048784655,0.070680484,-0.10536926,0.05629665,-0.0024332309,0.00024757872,-0.113477886,-0.027506344,-0.015312261,0.06984572,0.016810616,-0.03317833,-0.10171609,-0.094724104,0.02075317,0.054981887,-0.036215637,0.019921646,0.001922942,0.023055952,0.11659675,-0.02134997,0.032406844,0.04627487,-0.036679693,0.00741768,0.05076435,0.025390064,0.072122924,0.057383314,0.05436796,-3.558785e-08,0.08752135,0.016289214,0.066887625,-0.072172135,-0.06717909,-0.019620907,0.045713395,-0.010048552,0.116112046,-0.029938921,-0.08269389,0.035661705,0.08848151,0.037400503,0.061437838,0.059185755,-0.021063633,-0.054524485,-0.05232905,-0.10960289,-0.046400204,-0.04486893,-0.012204303,0.067394316,0.0298138,-0.085372835,0.07170216,0.0054198056,-0.004089625,0.05738316,-0.09246546,0.046952434,0.0019868605,0.014823171,0.036205735,0.0012719786,-0.0924081,-0.036258407,0.05054536,0.026586495,-0.05085446,-0.056589723,-0.058550637,-0.040902495,-0.048329793,-0.007973442,-2.3776924e-05,0.03882596,0.0448357,0.016438607,0.043135125,0.0010701242,-0.032280467,-0.055625483,-0.09845865,0.060701422,-0.054223493,0.05248261,0.024363602,-0.05928091,0.01729034,-0.02523486,0.06879364,-0.058553122 +3.5.4.31,The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 3.5.4.28) and has some activity against adenosine. Adenosine 5'-phosphate and S-adenosyl-L-methionine (SAM) are not substrates.,384,0.99999994,-0.04092109,-0.01157205,-0.07888115,-0.0029548965,-0.015860945,0.1048746,-0.043443985,-0.036634684,0.038586017,0.044378337,0.032024298,0.016158562,-0.06232579,0.04383191,0.008167322,0.06355245,-0.051083095,0.043912128,0.030704495,-0.069271706,0.04676981,0.030082455,-0.051102847,0.07540868,0.07016022,0.009494751,0.007108923,0.06448181,-0.08321621,-0.039686795,-0.053930152,-0.07504587,0.058952093,-0.0076603997,0.024702275,0.09076338,-0.10117396,-0.018573957,0.03192276,0.01669151,0.07294065,-0.007703834,-0.026044294,0.055174254,-0.04350786,-0.062454954,-0.08937928,0.04530757,0.034353275,-0.0053085396,0.032288384,-0.041011907,-0.010097149,0.00030423477,0.024402764,-0.011521519,-0.018795345,0.011676505,-0.05974405,-0.030579114,0.07404982,-0.011680494,-0.020016488,-0.00035119543,0.07364059,-0.09297798,0.03457154,-0.063179776,0.015462758,-0.008978968,-0.015155757,-0.07853056,0.029277755,0.066068515,0.011086554,-0.026422674,-0.037130505,-0.041308522,0.006953139,-0.008145998,0.10070252,-0.0048215026,0.066394195,0.038770147,0.026514947,-0.008114458,-0.015647002,-0.0071354923,0.0463537,-0.02116049,0.01596977,-0.015663462,-0.03185453,-0.026977824,0.016972093,-0.07475678,-0.03309693,0.020230109,-0.03242994,-0.035399858,0.019387573,0.07125362,-0.12411329,-0.11633396,-0.004231341,0.067248024,-0.012932007,-0.047587004,-0.019507566,0.015435092,0.0075697093,-0.015852502,-0.014489369,0.0010346363,-0.014539236,0.08355385,0.009522975,-0.052373335,-0.033351485,-0.027738055,-0.06174868,-0.013463209,0.050419785,0.1278923,-0.056085683,0.036984485,-0.052560337,1.6018449e-33,0.031030355,-0.036855757,0.01455617,0.010715111,0.03172937,-0.01738153,0.004332489,-0.00891719,0.009882148,-0.051137898,-0.06520069,0.03925711,0.048731964,-0.04807674,0.021713931,0.042327166,-0.018750148,0.00928778,0.04912059,0.05280068,-0.021764753,0.008270151,-0.05062454,-0.011730651,0.027829675,0.077525325,-0.054642692,-0.003186479,0.10799631,-0.0061916355,-0.030121258,-0.015916483,-0.15335038,0.06765454,0.014966798,-0.015575162,-0.09937303,-0.009168035,0.0017191493,0.072210476,-0.01661702,-0.012295952,0.08022583,-0.02457935,-0.03668522,-0.019353187,-0.0474833,0.0585375,0.00070434826,0.07152046,0.018030878,-0.048572894,0.045222696,-0.03589983,-0.0693973,-0.017514937,0.0015419275,0.001940007,-0.028670682,0.07181778,-0.015940435,-0.03590889,-0.012528974,-0.0476662,-0.059766516,-0.02643219,-0.097351454,-0.04866349,-0.006783054,0.08096093,-0.010246041,0.052284315,0.059571497,0.025814015,-0.028810255,0.0055726767,-0.03162794,0.04137486,-0.08071356,0.08567422,0.0037486965,-0.055234984,0.050715547,-0.014125999,-0.02191274,-0.08045994,0.018625697,0.008410907,-0.026401903,0.06380768,0.016939085,0.0071543413,-0.022012595,0.06122457,0.06569958,-3.5647616e-33,0.07749053,-0.08309829,0.042388964,-0.08222812,-0.070406035,0.059514593,-0.0058509866,-0.03667901,0.0060221883,0.033034783,0.06704603,-0.002633748,0.010203857,-0.07621712,0.042658463,0.0053448984,-0.03453917,0.06648442,-0.04844437,-0.0062219054,-0.047901005,0.13342758,-0.0115026245,0.021057814,0.001152147,-0.06322057,-0.013398116,-0.006993371,0.048626006,0.03376486,-0.007712574,0.008806384,-0.08697119,-0.013701759,-0.03143418,0.06702716,0.013185209,-0.0017093292,-0.020834776,0.03549478,0.061421458,0.11497912,0.021597918,0.12223521,0.038508143,0.08465745,-0.033778064,0.06532934,-0.02740879,-0.014607394,0.050576944,-0.08637284,-0.012938625,0.04712389,-0.004721938,0.060237404,-0.00574449,-0.00084278756,-0.0262183,-0.0005178543,0.015770467,-0.08190515,-0.055160258,-0.045444153,-0.040143605,0.039888863,-0.038021337,0.039344914,0.0828867,0.05747735,0.047709018,-0.0042675114,-0.029084207,0.04698623,-0.06939877,-0.004005071,-0.02490954,-0.032259326,0.08159161,-0.058485847,-0.019070946,0.064362995,-0.018919412,-0.07244497,0.086604975,0.033207815,0.028085845,0.074119024,-0.08740114,0.0384007,0.021595033,-0.044011984,-0.02163457,0.094971895,-0.062012263,-3.7033217e-08,0.1158934,-0.10507443,0.03395398,-0.11273603,-0.011187716,0.0056676376,0.040009923,0.06279607,0.048644446,-0.034803763,-0.028084876,0.07293128,0.027888797,0.04565732,0.054151773,-0.018000763,0.061837465,0.08349773,-0.014988268,-0.081370495,-0.06752838,-0.0366942,-0.12605985,0.036446992,-0.06142438,0.070438564,0.076913774,0.08690331,0.0172749,-0.011409249,0.0535012,-0.031182947,-0.06749027,-0.045777112,-0.0121976845,-0.006196188,0.030695252,-0.058353387,-0.04368986,0.02099143,0.041039396,-0.054069586,-0.031114148,0.03894523,-0.0027736854,-0.03026312,0.049853638,-0.05187913,0.016767552,0.0631773,0.041780055,-0.04219693,-0.052729253,-0.035813056,-0.12621006,-0.053886935,0.04289536,-0.085749604,-0.0034317523,-0.0584819,0.0021500865,-0.0043982123,0.17488615,-0.0052232943 +4.1.1.91,"In the reverse direction the enzyme catalyses the regioselective carboxylation of phenol into stoichiometric amounts of salicylate. The enzyme also catalyses the reversible decarboxylation of 2,4-dihydroxybenzoate, 2,6-dihydroxybenzoate, 2,3-dihydroxybenzoate and 4-aminosalicylate [1]. 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+4.2.1.127,"In absence of oxygen the bifunctional linalool dehydratase-isomerase can catalyse in vitro two reactions, the hydration of myrcene to (3S)-linalool and the isomerization of (3S)-linalool to geraniol, the latter activity being classified as EC 5.4.4.4, geraniol isomerase.",384,1.0,-0.043907616,-0.060537465,-0.07431213,0.019686192,0.023662996,-0.06470369,-0.0059886593,-0.032762874,0.047017362,-0.061563764,-0.012298739,-0.0142792445,-0.008503371,0.015198996,-0.05908576,-0.014071066,-0.06154129,0.06819936,-0.08688614,-0.031469207,0.062262196,-0.060255677,-0.0052003562,0.053662315,0.070681244,-0.043732926,0.06440681,-0.04061658,-0.04778016,-0.079733014,-0.011009368,-0.076567516,0.045337196,-0.10367491,-0.007759185,0.031411,-0.08168646,-0.061820436,-0.052296016,0.060989067,0.06302645,-0.09923927,-0.07979609,-0.014917544,-0.02534361,-0.027884841,-0.036717333,-0.06485445,-0.028993338,0.021309994,-0.08216833,-0.030421486,-0.064151116,-0.038182393,-0.048791647,-0.05201386,0.0735154,0.06884793,-0.04787996,0.0528389,0.048508123,-0.0080341725,-0.013019979,0.011640098,-0.020738967,0.013403738,-0.0036724354,0.017925287,0.008243876,-0.035202984,-0.028953016,-0.086615935,-0.07064942,0.0047848085,-0.083665766,-0.01533056,0.008548243,0.017915513,0.005059765,0.06043001,0.017333597,0.0035391042,-0.012261328,0.013230446,0.03872068,0.09496387,-0.0695233,-0.030765638,0.037004974,0.04485677,0.031204984,-0.0005746919,-0.0422156,-0.022177126,0.019704018,0.08634651,0.09882872,0.053266026,0.006570005,-0.05046011,-0.0010878732,0.025833355,-0.097053364,-0.0094371345,-0.0063563758,0.08876466,0.02492601,0.044609062,-0.012722493,0.024907857,-0.009008418,-0.06312179,0.061264772,0.03901993,-0.032045342,0.122552805,0.08818862,0.0044212025,-0.031280506,-0.016106466,0.020016596,0.027833708,0.05586561,-0.000732827,-0.033455715,0.013847751,0.0011027771,4.5342784e-33,-0.030530324,0.0002101856,-0.04204623,0.10001311,-0.11251008,-0.02413321,-0.0778155,0.025234893,-0.083539195,-0.05807537,-0.019717496,-0.011121033,0.023800006,-0.0016267382,-0.0746691,0.039990973,0.08217867,0.027237678,0.039649613,-0.018552173,0.04103579,0.015469578,-0.08887564,0.0028853589,-0.060410593,0.07390097,-0.023593957,-0.067139134,0.024121985,-0.04113439,0.04203037,-0.059183832,-0.00292701,0.07764906,-0.02690276,0.0013200007,-0.07680045,-0.021692019,-0.011140603,0.0361063,-0.050180946,0.03988182,0.034415036,-0.042935695,0.07406615,0.033387046,-0.028695242,0.09573772,0.004193277,-0.00716637,0.013514277,0.05685569,0.0073661925,0.020301592,-0.045974147,0.03231967,0.0031990279,-0.016763864,0.07102423,0.042826913,-0.01739517,0.11935185,0.019125756,0.00681905,0.0015035432,0.03065934,-0.085408315,0.037904676,0.05649394,0.04000998,-0.024909379,0.0385929,0.021979643,0.06974074,0.08485254,0.0025717474,-0.024949068,-0.08655521,-0.032210976,-0.034704126,0.020291712,-0.0077406983,0.026701855,0.08119197,0.010083288,-0.042912442,-0.068141684,0.02668059,-0.012632067,0.057361145,-0.0015644744,-0.01867098,-0.044843264,0.0044615753,0.020914078,-5.2068078e-33,0.17085382,-0.14298598,0.08655189,-0.08262842,-0.008463614,0.050138608,-0.025355496,-0.06555073,0.01696698,0.088205956,0.027015613,0.014534096,0.019071197,-0.05698756,-0.057107236,0.022508625,0.04065004,0.0475907,0.0143805565,-0.032248907,-0.00039354293,0.11933867,-0.0003039472,0.0016933986,0.02868052,-0.04420736,0.08439651,-0.027964413,0.08618985,0.09308805,0.00951156,-0.059984818,0.030278776,-0.03497786,0.032911897,0.048415113,0.0020052302,0.02448224,0.004032811,-0.027883887,-0.08768854,-0.0013660311,0.036780026,-0.008289851,0.05925445,0.02841178,-0.06050841,-0.019437457,-0.02042186,-0.036920622,0.05122384,0.005814389,-0.05377054,0.027864607,0.03851678,9.5291085e-05,0.07614167,-0.031705614,0.0005101703,-0.062494762,-0.0083606625,0.04011488,0.06735051,-0.020229064,-0.037627067,0.09622111,0.02760834,0.11458757,-0.031211361,-0.07928562,0.10637691,-0.05073969,0.009208021,0.07492976,0.03212417,-0.07686406,0.0011992487,0.006270429,0.024056489,-0.08949128,-0.020382525,-0.0359268,0.027122572,-0.12260638,0.0032861251,-0.110781215,-0.0019315807,0.09613897,-0.007885578,0.015967827,0.013014144,0.023785878,-0.07712733,0.028615752,0.15366921,-4.119753e-08,-0.025532085,0.013456293,0.03206177,0.015431249,-0.036545925,0.0457434,-0.035312492,0.02130259,0.025919862,0.025105141,-0.03187701,0.020984327,0.03686566,-0.028865412,0.061267763,-0.0013015255,0.034817044,-0.030898593,-0.0012343171,-0.026460411,0.0120432805,0.022927167,-0.07960832,-0.06422431,-0.017782087,-0.09217863,0.0024746903,0.020664604,0.06130519,-0.1161278,0.02779614,0.064252466,0.034682333,0.033508476,-0.006526977,-0.012478633,-0.049262036,-0.011042253,-0.014075649,-0.010185835,-0.08089064,-0.09076156,0.016413491,0.011719215,-0.0013799773,0.022043305,0.04459101,-0.09799482,0.018835088,0.024417523,0.08965596,-0.0057196957,0.065125324,-0.0078100087,-0.01422207,0.06292927,0.009346251,-0.0165085,8.374304e-05,-0.051848758,0.06723709,-0.034315605,0.12352465,-0.06501148 +4.2.1.128,"The reaction occurs in the reverse direction. The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol. See EC 5.4.99.41 (lupeol synthase).",384,0.99999994,-0.10631228,-0.11728838,-0.030419435,0.010114375,0.06744735,0.0065807938,-0.012411967,-0.010419882,0.09417165,0.05725492,0.06025958,-0.006090264,-0.10742532,-0.08889998,-0.04647523,0.06600599,-0.085379325,0.0609616,-0.07701544,-0.048501197,0.058759853,-0.046085622,0.021859536,0.01851192,0.03453218,-0.0067035,0.02752437,0.035693843,-0.0031177094,-0.08674193,0.061123814,0.07518193,0.008033003,-0.032588728,-0.07446832,0.065732695,-0.0403482,-0.13596658,0.053225894,-0.011353183,0.04593857,-0.0024397543,-0.07081393,-0.030133715,-0.06733546,-0.053547006,-0.11031386,0.06685754,0.07825695,-0.050848406,0.027472626,-0.02650547,-0.036181238,-0.026883367,0.0004728218,0.013764783,0.030868381,0.0043833656,0.06439187,0.05511175,-0.012492341,0.060885042,-0.08833253,-0.041969445,-0.028647278,-0.017382232,-0.031370513,-0.04104746,0.03321343,0.010062576,-0.08101071,-0.060570884,-0.012564032,-0.0077795596,0.0027327477,0.031156441,0.02997859,0.032842796,-0.017762171,-0.021495055,0.022197327,-0.041283097,0.08438991,0.017751126,0.054187182,-0.029850094,-0.012722611,0.036782075,0.10512383,0.06486141,-0.028662242,-0.008707098,-0.031294744,-0.011151093,0.052691396,0.12105332,0.0013378601,-0.030733325,0.05484173,0.0047214106,0.022690944,0.0013064588,-0.018672656,-0.1289602,-0.042063475,0.041936178,0.014333935,0.029131114,-0.03060208,-0.042921517,0.014301404,-0.01858042,0.08587819,0.046159066,-0.051172677,-0.017975725,0.0030699966,-0.06492789,-0.050708815,-0.06627592,0.015956692,0.0012825744,0.017418392,0.0148105165,-0.07420469,-0.018948678,-0.0859083,3.490679e-33,0.08178042,0.045180537,-0.08586681,0.022680596,0.040288016,-0.014208839,-0.04013251,0.077192485,-0.099597186,-0.063620105,-0.07446076,-0.04026565,-0.0068531972,-0.0058557466,-0.019696556,-0.023109844,0.034165006,0.011535342,0.049114127,0.006109629,-0.011373784,0.005210957,-0.07920671,-0.04950169,-0.00092004944,0.039033152,-0.077488236,-0.014440479,0.04326044,-0.02526296,0.018777037,-0.04437188,-0.001064668,0.09554135,0.021473859,0.052648768,-0.031380363,-0.06661784,-0.0019442278,0.024688726,0.05886755,0.054949056,-0.024847727,0.061059885,0.040484123,0.09177758,-0.0184423,-0.030707024,0.07359732,0.09720833,0.013380925,-0.005771203,0.106852435,-0.039330192,-0.03558258,0.060297538,-0.016493484,0.0053438884,0.06655312,0.07609587,-0.07670266,0.11244979,-0.016987648,-0.006914919,0.013269221,0.040681306,-0.049323317,-0.047213178,-0.019164238,0.006445194,-0.07838503,-0.032276258,0.03761006,-0.024393255,0.040679272,0.0047099325,-0.03235274,-0.010639198,-0.024031112,-0.023220109,0.009304728,0.043064196,-0.018452087,-0.007110108,-0.021879647,0.008527546,-0.061741292,-0.0317498,-0.014548064,0.05689243,0.08817047,-0.086652644,-0.0052116085,0.020993695,0.061695263,-3.660979e-33,0.03186326,-0.04746135,0.0086370725,-0.025758011,-0.078679815,0.060119953,0.06136155,-0.077942826,0.049332626,0.050757788,0.06699706,-0.045095686,0.022448905,-0.019966515,-0.07250156,0.039132476,0.07649025,0.07984692,0.0041740206,0.0024975727,-0.035860293,0.10295071,0.09950176,0.002717638,0.019221555,0.0050341026,0.1042533,0.07153311,0.019229759,-0.041471094,0.017718054,-0.060163867,0.053103782,-0.06727874,-0.060972042,0.0040294584,-0.061037127,-0.04179278,0.018207023,-0.025921807,-0.007556122,-0.0057877386,0.027129661,0.049060617,0.02933591,0.016608829,-0.04619329,0.0073052114,-0.023292173,-0.033335503,0.027838962,0.027323203,-0.04504845,0.0506047,0.0016450455,-0.038699284,0.0890239,0.0123879695,-0.02497469,0.0084170895,-0.03239094,-0.014253811,0.04591175,0.019726781,0.08474934,0.12566577,0.025182497,0.06509318,0.032681134,-0.0058260234,0.14197187,0.05054249,0.013928877,0.06272273,0.06473832,-0.0012673878,-0.050150722,-0.034347814,-0.03789109,-0.0351128,0.028445689,0.0029080133,-0.022657739,-0.06313176,-0.09099774,-0.123550996,0.026082097,0.10291548,-0.015806064,0.01669728,0.04032932,-0.008425868,0.009096837,0.034741167,0.15887803,-3.7514226e-08,-0.062334977,-0.04029494,0.016960077,-0.041231953,0.020361615,0.0453082,0.08028937,0.02831092,-0.01725446,-0.025461365,-0.0799566,0.09944893,0.023694653,0.010296499,0.05510066,-0.0013163714,-0.056392405,0.0013191592,0.0071992325,-0.03901239,0.008575329,0.053712737,-0.053554267,-0.00073231803,0.011661515,-0.08819255,0.0041981027,-0.021643732,0.009066742,-0.04664407,0.009372085,0.028904699,-0.050675727,-0.060186055,-0.053196833,0.006384137,-0.0690143,-0.039818235,0.044582076,-0.029884394,-0.016457561,0.017230647,-0.0067107826,-0.018256232,-0.0581127,0.02760045,0.0197589,-0.0070219226,0.06721033,-0.0025867496,0.08904444,-0.0051103276,0.026559548,-0.1052186,-0.09224161,-0.07981279,-0.019692617,-0.06306293,0.04057592,-0.022496175,-0.025900101,-0.021267466,0.08361761,0.006228096 +4.2.1.129,The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1. ,384,1.0,-0.0763448,-0.010352485,-0.042186946,-0.01329355,0.052324712,-0.0040451596,-0.020174935,0.07773129,0.010667728,0.011317954,0.017717583,-0.050288856,-0.033723645,0.042485707,-0.10690556,0.042572234,-0.08166668,0.048147038,-0.07189549,-0.02458694,0.0903807,-0.01570535,0.014495298,0.071345486,0.037469767,-0.030661426,-0.010793911,0.0071421484,-0.018093333,-0.020136612,0.03714593,0.028034745,0.032827407,-0.07689587,-0.014783494,0.01750689,-0.07197509,-0.0035335228,-0.02176243,-0.016184514,0.03930596,-0.011606359,-0.0605846,0.013530393,-0.007837796,-0.0044104564,0.04469636,0.064534,0.014970664,-0.022377811,-0.059858833,-0.04807782,-0.0836703,0.007553788,-0.012635779,0.032409213,-0.07450282,0.0180125,0.041237645,-0.007167731,0.03665465,0.03134485,-0.035666198,-0.03639916,-0.035836797,-0.033795174,-0.008051829,-0.028022798,0.027584115,-0.013734978,-0.03977256,-0.046327114,-0.037545983,0.008504653,0.046752322,0.050809044,0.011568248,-0.05174479,-0.015296959,0.01303822,-0.0050563547,-0.0064446223,0.010675821,0.036651224,0.040275402,0.077590264,0.0632441,0.071597904,0.057386715,-0.0069167474,0.04721967,0.024675125,-0.07564656,-0.07425693,-0.016193025,0.046390478,0.0058208997,-0.031504598,0.049165875,0.006790333,0.053558327,-0.10527316,0.022504225,-0.15152909,-0.09019137,0.07784862,0.093558736,0.04623965,0.05539844,0.020006444,-0.06910069,-0.005658306,0.0022909122,0.014193679,-0.049346693,0.13427435,0.01245142,-0.036117386,-0.005780528,0.021587826,-0.013402596,0.0419133,0.057862107,0.086736344,-0.05220549,0.024838595,-0.034781653,1.7719587e-34,-0.0065729613,0.04586569,0.06421278,0.013906376,-0.027297396,0.028657552,-0.03973052,-0.041719493,-0.038107492,-0.06927326,-0.10191434,-0.04590967,0.0054744086,-0.03504866,-0.054551963,-0.0627294,0.005196619,0.027512815,0.04505918,0.0012999416,-0.07355711,0.024822906,-0.12546425,0.02060528,0.00209358,-0.008163321,0.01221871,-0.012879427,0.07007421,-0.039996985,-0.025116408,-0.017845087,-0.031195,-0.049234923,0.025376277,0.0644468,-0.009105179,-0.023295084,0.040948868,0.0802071,0.008700024,0.004105726,0.054041322,0.029772025,0.03622068,-0.02478087,-0.05511644,0.04647039,0.071413666,-0.008508333,0.034232855,0.0056538996,0.037095524,-0.014384739,-0.049417432,0.03752831,-0.0014199977,0.043750767,0.07377494,0.03609268,-0.0145030245,0.07015862,-0.042868644,-0.032405466,0.0053845984,0.08560479,-0.09001855,-0.00208775,-0.06783388,0.047863282,-0.07631176,0.0059060077,0.07913958,-0.013072296,0.06207088,0.05090875,-0.025038421,0.008012507,0.08213947,-0.012736712,-0.08166368,-0.02960032,-0.07838401,-0.007877952,-0.08400612,-0.0554089,-0.019669233,-0.05660868,0.040481586,0.1040508,0.120620534,-0.15138356,-0.016758645,0.034834098,-0.07385284,-1.2659176e-34,0.03306083,-0.014605082,0.06537264,0.030517573,0.040035896,0.08148286,0.0027660513,-0.11570109,-0.037176836,-0.018616918,0.08420503,-0.062267117,0.060001243,-0.011013566,-0.034561336,0.03881106,0.09055449,0.03782756,0.01373649,0.030870857,-0.024425939,0.0028006923,-0.039702013,4.2326006e-05,0.009192058,0.028197942,0.03706198,0.093397975,0.12674984,0.01943255,-0.026671546,-0.06558089,-0.06294709,-0.010396635,0.038967527,0.040444836,-0.021324007,-0.00292614,0.022641601,-0.0073602227,-0.051810127,-0.06269599,-0.02436684,0.092454635,0.060952634,0.087594025,0.048127618,-0.021527516,-0.007984134,-0.06117627,0.09428588,0.093323015,-0.041681517,0.045103136,0.0076719564,0.042083483,0.027259843,0.040131073,-0.025581498,-0.03309241,-0.04445539,-0.06915936,-0.022280792,-0.0582697,0.019192657,0.022228198,-0.04622721,0.10376823,-0.021768946,-0.003461495,0.08306134,0.021378554,0.07152337,-0.0014601685,-0.043838773,-0.034124162,0.0612098,-0.084669515,0.023039617,-0.06431838,0.018490903,0.030072393,-0.027103372,-0.07858193,0.015928864,-0.07707366,0.095328934,0.06820954,0.050328583,0.032953296,-0.025501998,-0.0021490762,-0.09677632,0.09896239,0.13776785,-2.7972904e-08,0.01796637,-0.0692021,0.022961216,0.00029859348,0.005977547,0.040376257,0.08394655,0.0026057474,-0.014651551,-0.013254975,-0.030439017,0.04104019,0.0069277775,-0.030392185,0.08865774,0.0140958335,-0.0496451,0.014842827,0.042201605,-0.04417897,-0.043387014,-0.0076326015,-0.13574365,-0.080209665,-0.10197071,-0.095371336,0.041595336,0.06318741,-0.07630631,-0.057665832,0.017069908,0.01399591,-0.021471925,0.011215341,-0.007087953,0.017307272,-0.08131232,0.060900744,0.008040806,0.036104623,-0.017769648,-0.016573584,-0.050927732,-0.012837751,0.0035031235,-0.03838742,0.021315461,-0.039050203,0.064130805,-0.009522931,0.033266585,0.034534886,0.028093593,-0.034055147,0.016154876,-0.00034252703,-0.00045513661,-0.026340703,-0.06172019,-0.06273475,-0.06549295,-0.04088789,0.14508642,0.011275251 +4.2.2.23,The enzyme is part of the degradation system for rhamnogalacturonan I in Bacillus subtilis strain 168 and Aspergillus aculeatus. ,384,0.99999994,-0.029798422,-0.02028858,-0.06947516,-0.027231973,0.08289735,-0.008059043,-0.051695988,0.052032348,-0.004354014,-0.063204445,0.014811833,0.01546214,-0.005993962,0.07779942,-0.12758626,0.085399054,-5.6286623e-05,0.039886262,-0.028896462,-0.010309881,0.09728681,0.0639833,-0.036903158,0.014788754,0.031186618,-0.028727515,0.02585477,-0.051593408,-0.06059009,-0.04161711,0.021569617,-0.027251037,0.0736251,-0.048227064,0.03820769,0.12790453,-0.054163273,-0.06234823,0.16594508,0.031494744,-0.023504257,0.025481552,0.032390043,-0.03023312,-0.017308565,0.0084400335,-0.11684419,0.036573924,0.04351843,-0.031622622,-0.059651077,-0.015028205,0.0420703,0.034500964,0.073391065,-0.017181385,-0.10645663,-0.057518136,-0.089573935,0.047693163,0.08079001,0.024344454,-0.010115904,-0.04797428,-0.051827226,0.019170912,0.003393665,-0.048033167,0.00044971157,0.04678358,-0.055249665,-0.036087096,-0.03064721,-0.048488535,0.03717586,-0.042605367,0.004647565,-0.050302908,0.0028724456,-0.036332022,0.03559022,0.040530235,0.045358967,-0.0050018085,0.023090543,-0.030997446,0.04628128,0.017192407,-0.024227254,0.053245615,0.024822015,3.9551065e-05,0.017616956,-0.024563238,-0.02353055,-0.035112746,-0.011413653,0.03703331,0.031185295,-0.028608596,-0.069289215,-0.004299144,0.037351534,-0.06579391,-0.068446554,-0.019123986,-0.004295165,0.06547713,0.095301785,0.0005929275,0.019626293,0.005575874,-0.03475382,-0.051139906,0.0085274605,0.042118795,-0.00022814191,0.02173428,-0.112119146,-0.006910379,0.008390853,0.0123457145,-0.015727747,-0.027510459,-0.0003213517,0.0033752248,-0.05606647,3.542785e-33,-0.02845588,-0.065387964,-0.086109966,-0.053543277,0.036463954,-0.04703394,-0.036583807,-0.011511814,0.057601426,-0.095147766,-0.05599823,-0.08676694,-0.10324708,0.036873773,-0.024285512,0.037211295,0.04092007,-0.047554966,-0.00046910314,0.00010996038,0.009972288,0.022625193,-0.049855366,-0.03049537,0.006897822,0.034799963,0.049576364,0.010001637,-0.00651173,-0.030030418,0.091649674,-0.02196204,-0.15936287,0.021851705,0.051826604,0.022448778,-0.0021200345,0.007234752,-0.05228323,0.012030806,-0.040014144,0.058653217,-0.03173813,-0.03698733,0.04384462,-0.029241763,-0.014879092,0.13127843,0.1115247,0.06494756,0.025778502,0.02439037,0.103810474,-0.034053646,0.0037389616,-0.020296304,0.009437031,0.06110749,0.024920091,-0.012542624,-0.03721272,-0.02331836,-0.00088524196,0.033092715,-0.0020634506,0.039404497,-0.023786904,-0.040568408,0.050044928,-0.0114589855,-0.06432954,0.027648984,-0.023626463,0.020474926,-0.0067688487,-0.05754961,-0.008576765,0.014481455,-0.0018477577,0.014783563,-0.0421581,0.02154196,0.03572931,-0.048625283,-0.018207835,0.012621232,0.03346475,-0.019101257,0.10527828,0.029467806,-0.0056162034,-0.11328057,-0.063356586,0.07634028,0.07295278,-3.9797485e-33,0.123832494,-0.09269299,0.029078327,0.010789129,-0.10402706,0.051338222,0.013702793,0.12659955,-0.029216977,-0.0040922617,0.013951659,0.03910159,-0.017570632,0.06632593,0.072528295,0.056321643,-0.020221217,0.06494444,0.012527772,-0.03971131,-0.08457582,0.15798613,-0.016223168,-0.010296964,0.02762058,0.053759377,-0.025960665,0.100557975,0.02387179,-0.040799953,-0.0034753194,-0.0016159676,-0.041634288,-0.041131075,-0.072919466,0.11273631,0.0013005328,0.0276147,-0.02954244,0.04963017,0.047863465,0.053675808,-0.02356151,0.023667872,0.026152547,0.027720999,-0.061957512,0.0013596966,-0.022350656,-0.084111445,-0.0033820888,0.0153722735,0.039739534,-0.055057414,0.02469591,0.023831949,-0.0037108106,0.061141986,-0.0041644345,-0.0797129,-0.089887366,-0.07677752,0.035713587,0.03446705,0.04650709,0.05350083,0.017628338,0.029780064,0.1030439,-0.025475953,0.032148637,0.06950785,0.04567738,0.028262807,0.0029604095,-0.064906284,-0.09701371,0.005498823,0.005896087,-0.002014447,0.08156986,-0.05826186,-0.023385597,-0.048355196,-0.03251173,-0.038932107,0.079334274,0.078578226,-0.06813478,-0.03487589,0.042417135,-0.025860539,-0.10599908,0.011897441,0.07872482,-2.8690001e-08,0.08445603,0.01777523,0.0425716,-0.05963792,0.08870516,-0.008828192,0.027835988,0.040779766,0.031794254,0.02904988,-0.064609036,0.040563256,-0.040007733,-0.013887334,-0.0040450296,-0.04801477,-0.081588306,0.018257095,0.02301603,0.08280887,-0.051640086,-0.035646163,-0.09367396,0.059313603,-0.0057490994,-0.055268254,0.081686236,0.03316669,-0.037776705,0.015906885,0.007719656,0.08373524,0.0419174,0.02533725,-0.08894051,-0.015975125,-0.051750883,-0.02153517,0.008412872,0.03975214,-0.024345607,-0.007006577,-0.04252958,-0.0149133615,-0.035404246,-0.059739374,-0.035129167,-0.009757711,-0.015669396,-0.030474013,0.04041882,-0.04942288,-0.020728003,-0.019174768,-0.05817194,-0.00052280334,0.04935286,0.00042979518,-0.07895534,-0.05353525,-0.01036155,-0.014416988,0.1404843,-0.07971537 +4.2.2.24,The enzyme is part of the degradation system for rhamnogalacturonan I in Bacillus subtilis strain 168.,384,0.99999994,-0.037404045,-0.041194838,-0.044994794,-0.049520604,0.057583254,-0.0035250573,-0.056905247,0.054284386,-0.003460664,-0.05634898,0.009081654,0.009739098,0.021527844,0.061883334,-0.103800975,0.08607191,-0.03946511,0.03385931,-0.018138567,0.012921089,0.11800533,0.062441893,-0.050689317,0.005918928,0.032779276,-0.029968126,0.047539815,-0.058476187,-0.053723037,-0.016346857,0.049015384,-0.019144448,0.07660892,-0.061640415,0.03758085,0.12886469,-0.046748787,-0.0797571,0.16421328,0.017710691,-0.014519959,0.056789212,0.037292458,-0.029725475,0.015158261,0.03007217,-0.09673769,0.030069565,0.03217532,-0.04652268,-0.05726085,-0.022847213,0.036040805,0.044477023,0.07348275,-0.06580694,-0.10416073,-0.03648396,-0.06126036,0.06556705,0.08403539,0.039162163,0.02325454,-0.06069332,-0.030889584,-0.011672307,-0.0035851682,-0.03921356,0.020311624,0.04678423,-0.072469175,-0.013784565,-0.030546207,-0.040406544,0.012587447,-0.053786777,0.006753712,-0.042414755,-0.014336649,-0.035642814,0.016204653,0.02614879,0.047821794,0.028615613,0.025922064,-0.025849694,0.045332175,0.0056568817,-0.022127392,0.05913269,0.02296388,-0.017431993,0.012340307,-0.037002973,-0.021124676,-0.056542397,-0.052418105,0.01662519,0.036702983,-0.028184298,-0.08908661,0.0061608804,0.022629784,-0.074089624,-0.10203649,-0.010566855,0.0035379983,0.068705186,0.07887053,0.012640743,0.030172566,0.02811921,-0.026173145,-0.049613696,-0.011767309,0.06098527,0.004888492,-0.008592226,-0.12802237,-0.0147754885,-0.011137034,-0.011427505,-0.0013200553,-0.024110734,-0.025988774,-0.00878917,-0.056217562,1.9979306e-33,-0.01919391,-0.08053359,-0.05927197,-0.05837504,0.024766872,-0.043395285,-0.050566204,-0.016872784,0.04469299,-0.10449827,-0.06847194,-0.11007711,-0.0767996,0.028282963,-0.025420548,0.053584456,0.031529963,-0.039394144,0.004219551,-0.008461267,0.0014516714,0.0074114427,-0.027690759,-0.063615024,0.008004503,0.029685766,0.057042267,0.004524788,0.005849869,-0.031320084,0.097669624,-0.04564306,-0.1427559,0.024693882,0.0332072,0.016154725,-0.022326985,0.0125213545,-0.04765383,0.03718377,-0.036374755,0.07169594,-0.017041042,-0.01787004,0.057354894,-0.012649542,7.286413e-05,0.12689158,0.09976408,0.06584452,0.0025969816,0.023394605,0.101021186,-0.055732086,-0.005152646,-0.025986776,0.034414895,0.04494239,0.019534927,-0.011732746,-0.015895719,-0.0057228603,-0.0035839712,0.026925806,0.008333656,0.048152473,-0.018728217,-0.03501217,0.055468407,-0.0059596132,-0.07215326,0.015708957,-0.0075664306,0.012302916,-0.01886292,-0.048700478,-0.005765106,0.009212751,-0.008624811,0.03504058,-0.029764125,0.0033081493,0.016585099,-0.047575437,0.009131533,0.01667677,0.008786193,-0.036424268,0.10167318,0.0506367,0.023794906,-0.13169938,-0.077235505,0.08081262,0.037741154,-2.1633359e-33,0.112536155,-0.07684729,0.03552706,-0.007816923,-0.0862767,0.036916018,0.002004265,0.12237913,-0.022778776,0.007156389,0.014062891,0.025601022,-0.027422253,0.070998505,0.066549756,0.060907476,-0.01107596,0.060291123,-0.0017299915,-0.035713512,-0.066752285,0.16362745,-0.013248216,-0.038597472,0.024434984,0.060242996,-0.021895723,0.12756096,0.03742418,-0.044364773,-0.0051287753,-0.016873872,-0.06627605,-0.050784368,-0.049638737,0.092606604,-0.012013342,0.009604386,0.00064809015,0.031807236,0.045842994,0.07847071,-0.022818137,0.01745911,0.031345498,0.030716999,-0.061117206,-0.011661409,-0.014967451,-0.07006706,-0.0031920162,0.01396681,0.057459284,-0.04170411,0.042201344,0.01570185,-0.030630393,0.10155038,-0.04029005,-0.07315747,-0.07542961,-0.08901851,0.059976395,0.01895008,0.024246447,0.074758396,0.046231806,0.05905457,0.08780918,-0.033688635,0.03169187,0.059701025,0.06759154,0.039905965,-0.018833555,-0.042803727,-0.11590676,-0.013415834,0.0074270098,0.0009994911,0.08740373,-0.044034723,-0.04441444,-0.055176057,0.0040175808,-0.0043829656,0.054340478,0.07556198,-0.021282801,-0.04720645,0.046966065,-0.046778403,-0.08154291,0.0055042184,0.06717615,-2.4580709e-08,0.06626869,-0.028313333,0.03451922,-0.033631776,0.09276284,-0.011886751,-0.0029540053,0.049076896,0.006119851,0.031498414,-0.033398237,0.04762032,-0.050597645,-0.030806705,0.002406339,-0.047392663,-0.07123608,0.0074637863,0.017701054,0.066422224,-0.05347908,-0.030079665,-0.087513685,0.068720944,0.008606768,-0.07572558,0.06851022,0.012689833,-0.044773873,-0.022531755,0.03048279,0.07878617,0.037035126,0.040654268,-0.1075024,-0.0067368797,-0.07078917,0.02406806,0.018761614,0.046522647,-0.0015042026,0.009390706,-0.050414342,0.0055533946,-0.017314583,-0.018193813,-0.04418797,0.0071466323,-0.03677069,-0.038658705,0.041377954,-0.038799122,-0.0067924326,-0.00677779,-0.07484966,0.01665248,0.035740767,-0.0011746907,-0.056468256,-0.0424506,0.0031635258,-0.017433083,0.14313146,-0.0773104 +5.2.1.13,Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis. ,384,1.0,-0.059286866,-0.03361789,-0.10286204,-0.030644009,0.08663974,-0.011719315,-0.095000245,0.05373583,0.014503437,-0.056420144,0.020123724,-0.0971072,-0.09658604,0.009003617,-0.0048929104,0.024711208,-0.038953565,-0.04849911,0.0018103946,-0.06315913,0.09465934,-0.014214506,-0.0070643285,-0.024475852,0.022528812,-0.01890107,0.030304886,-0.052849535,-0.00061328034,0.012243106,-0.030048322,-0.029503541,0.06124708,-0.03539179,0.011369852,0.097207,-0.037385695,-0.017268186,-0.009226536,0.017537128,0.05231118,-0.07257502,0.025765799,-0.033699423,0.052886207,0.02908565,-0.006300566,0.07508735,-0.021321345,0.04924637,-0.076443985,-0.021955086,-0.04129479,-0.08240958,0.023418004,0.029486047,-0.052461132,0.006951278,0.0029909648,0.05480525,0.023204865,-0.02737293,-0.02477949,-0.012291115,0.08889624,-0.03421408,-2.0338053e-05,-0.07408509,0.024791261,-0.031547748,0.005508034,-0.014043964,0.015595577,-0.055469465,0.0022903304,0.0026747352,-0.073795564,-0.041516658,0.03620833,0.0021916132,0.04112831,0.024808485,0.03317998,0.091512315,0.03422416,0.021335075,-0.012885424,0.0053383377,-0.06598694,0.03575633,0.02609888,-0.06217782,-0.058809783,0.048330106,-0.033350244,0.06329211,0.11491115,-0.09109006,-0.029814264,-0.049179167,-0.06508124,0.06975709,-0.0045980574,-0.024144987,-0.08371936,-0.05688328,-0.028584488,0.07544804,-0.042652547,0.004405222,0.044850938,0.043208595,0.062511034,-0.040985633,-0.008465126,0.040336203,-0.08546623,-0.10152102,-0.03411889,0.07092024,-0.04961875,0.08104345,0.001413818,0.10125079,0.0040079034,-0.031558093,-0.05789828,-1.8177857e-34,0.032301463,0.07428678,-0.00434458,0.004826894,-0.0013756347,-0.03249006,-0.09587872,-0.03799771,-0.031016147,-0.052310064,-0.022670738,-0.124358885,0.049257156,-0.036408912,-0.016152507,-0.008026893,0.009666646,-0.043643706,0.06574016,-0.036234085,0.029632462,0.03569951,-0.019076016,0.027106898,-0.038884886,0.06853052,0.007234976,0.021803956,0.060793746,0.039490566,0.03034337,-0.05821309,-0.04657925,-0.030916113,0.06273709,-0.0036731998,-0.07221517,-0.06364664,-0.09904486,0.041415915,0.02192784,0.08698866,0.008713749,-0.021221414,0.055046834,-0.08696336,0.04418225,0.11158103,0.051476393,0.10886894,0.029539347,-0.010860541,0.0944988,0.021109696,-0.044708095,-0.007276935,-0.026645605,-0.053384345,-0.013002527,0.00030550847,0.01081852,0.05218681,-0.042650726,0.03193001,-0.069367774,0.025931936,-0.058381747,-0.057608303,0.0048866817,0.09895894,-0.0001338975,-0.037499405,0.058267847,0.024242688,0.03870342,-0.021308417,0.016903386,0.024121147,0.02315926,-0.0015675152,-0.025266426,0.011032284,0.03660424,-0.0528068,0.0036508278,-0.02111942,-0.021197781,-0.044204194,0.0061054872,0.05217711,0.012910503,-0.097323395,-0.028428176,0.0051036864,0.07477655,-1.146007e-33,0.07207358,-0.094438374,0.048481222,-0.033817273,0.034068577,0.03591039,-0.034429744,-0.13769281,0.07411936,0.031490576,0.039644584,0.035499506,0.034409188,-0.016751371,0.07607445,0.037593797,-0.049570758,0.06953773,0.017113777,0.0237415,-0.012975271,0.08975845,0.0055085127,0.07206395,0.05100032,0.036180437,-0.06140783,0.054036573,0.065012604,0.017535321,-0.017254205,-0.02981934,-0.11803795,-0.0115201585,-0.05457653,0.026518803,-0.065581135,0.041163728,-0.02893539,0.07828996,-0.010835287,0.049656004,-0.00065226975,0.06296595,-0.0056665945,0.0522825,0.0025268877,0.03208467,0.016995298,-0.09356424,0.011708837,-0.0068350714,-0.056055464,-0.0019347685,0.05556987,0.05985311,0.078324825,0.08281206,-0.028909361,-0.03854647,-0.016725065,-0.11767214,0.008879437,-0.04212259,0.0436541,0.0072034677,0.025740992,0.11743241,0.058657154,0.038694873,0.06843012,0.091503814,0.056099787,0.023293875,-0.011308519,-0.04034382,-0.09889284,0.015412424,0.030998802,-0.05889859,0.032423653,0.052579563,0.012102311,-0.0015108036,-0.020337747,-0.05434515,0.07751081,0.073710896,-0.033451863,0.018203244,-0.03792323,-0.0093460595,-0.0040481156,0.027182397,0.09035354,-2.3179036e-08,0.005805093,-0.01663526,0.03040665,-0.08436061,-0.0018414378,-0.007439127,-0.030942775,0.0063786292,0.0149458535,-0.033396125,-0.04605473,0.06251035,0.048987754,0.022152146,0.034100186,-0.06508515,0.032730762,0.014283751,-0.05244612,0.011280954,-0.13110097,-0.016696582,-0.13125843,-0.022020439,0.018240204,-0.06632392,0.035566155,0.004256252,-0.03231278,0.004218054,0.05425579,-0.01775442,0.020317314,-0.035910744,-0.14026247,0.07312405,0.029142812,-0.012843746,-0.05244334,-0.01136056,0.012468541,-0.023265645,-0.021552764,0.01570668,-0.057284907,0.003125863,0.043716975,0.00023372524,-0.038460128,0.020434093,-0.028639628,-0.04494629,-0.0076733585,-0.04664347,-0.06526963,-0.01710883,0.0011950557,-0.06523657,0.029601384,-0.059380595,0.08563575,0.09719467,0.17920022,-0.039476905 +5.3.3.17,"The enzyme is involved in phenazine biosynthesis. The product probably spontaneously dimerises to 1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate",384,1.0,-0.080177106,0.007884769,-0.09926716,-0.020791287,0.029837122,0.04597877,-0.017400326,0.12104928,0.018233713,0.069202535,-0.018147275,-0.0032059706,-0.047502503,0.013010417,-0.06930949,0.020550417,-0.12989224,-0.042324968,-0.09392259,0.011294692,0.07272473,0.023909077,0.03861178,-0.012369998,0.026910098,0.046987183,0.11934994,0.016068324,0.061145026,-0.053905915,0.04783097,0.05018108,0.059852093,0.0132397795,-0.010462079,0.05359646,-0.024146909,-0.035953216,0.07106865,0.038033858,0.04610573,0.001347384,-0.08468122,-0.052479926,-0.037134547,-0.0548124,-0.017750466,0.09896818,-0.0011408747,0.052118905,-0.009106831,0.025619537,0.0025630842,0.01531023,-0.0019701377,-0.05809043,-0.040455345,0.0023190305,-0.04150213,0.0460571,0.082345225,0.00537762,-0.064234644,-0.028839795,0.039394267,-0.03279679,-0.023197694,-0.027153896,0.024577541,-0.081642605,-0.061739266,-0.043958046,0.03821329,0.034777716,0.028778095,0.013511667,0.047612812,-0.0057376227,0.004252289,-0.0029440145,0.019856362,-0.04105481,-0.0048630196,0.035991028,0.05902639,0.04133661,0.005771804,0.04528775,0.13100575,-0.024147976,-0.028083397,-0.042374294,-0.058227472,-0.025614312,-0.13067399,0.0567045,-0.024281774,0.0075758277,0.019989667,0.026246576,0.049580555,0.005058106,-0.047519077,-0.03827512,-0.07368597,-0.0768027,0.08295195,0.05308193,-0.02018106,-0.0074429945,-0.050212152,-0.018009685,0.04435876,0.046029933,-0.0504155,0.07336229,-0.045620833,-0.07110544,-0.06424967,-0.020726025,-0.0001506514,0.013119101,0.03813589,0.034261778,-0.08471854,0.018330645,-0.10839749,1.2105687e-33,0.009378857,0.07701135,0.036883555,0.027826566,-0.03146506,0.020133551,-0.08648613,0.015500348,-0.0355164,-0.04008202,-0.056354113,-0.05798065,0.03548037,-0.017112631,-0.026219945,-0.04441708,-0.009442418,-0.000400049,0.07973671,-0.0359571,-0.0054009655,0.051354107,-0.07059663,0.052652206,0.07075036,0.06964695,-0.011345915,0.056490075,0.03951638,-0.013857253,0.012771861,-0.031077538,-0.057035424,-0.08373061,0.04034293,-0.0065663587,-0.08917364,-0.0047905757,-0.04122413,0.019790867,0.06379226,-0.050659973,-0.029782608,0.054898463,-0.0043777796,-0.0051922346,-0.016045503,0.04659608,0.078782156,-0.03746564,-5.003191e-07,0.047418434,0.12831998,0.0034077526,-0.103392415,0.04828376,-0.030048765,-0.05365784,0.092509426,0.026849018,0.03872144,0.0303925,-0.04753575,0.087596744,0.002352386,-0.051497318,-0.030528445,0.0139778955,0.027154377,0.118999496,-0.053429242,-0.03405471,0.013741541,-0.0045740353,0.052765116,-0.012260453,0.036486674,-0.04193346,-0.025382468,-0.0016696661,0.047446862,-0.012859237,-0.024059575,-0.01997147,-0.10827198,-0.023847464,-0.036945283,-0.07469011,-0.07213238,-0.01153456,0.13534796,-0.09491233,-0.028694047,-0.031125117,0.052847907,-3.073197e-33,0.032017104,-0.053403217,0.035105087,-0.034150194,0.08647966,0.08457839,0.034615338,-0.041575234,-0.012259147,0.004438855,0.03241317,-0.030854123,0.00019430561,-0.03158385,0.046666574,0.06943364,0.08178015,0.005866145,0.10739723,0.013652643,0.0048059537,0.036657937,-0.03183568,0.0006792413,-0.048007093,0.04718683,0.072036535,0.051011313,0.046193007,0.053809345,0.020878145,-0.026766313,-0.042560555,-0.02447859,-0.026628017,0.050682202,-0.033456158,-0.046189204,-0.042579874,-0.04368981,-0.04517783,-0.020946493,-0.0047074463,0.017248996,0.059671365,0.012486293,-0.03911254,0.011110741,-0.0376182,-0.0025879429,0.07920484,0.09790884,-0.055016108,-0.032223716,0.07959225,-0.0137271425,-0.010913987,-0.060567744,0.0605322,0.0018781408,-0.022269385,-0.06925459,-0.0040205843,-0.005477599,-0.015666464,-0.008035544,0.02673832,0.09900463,0.023860488,-0.029545622,0.09035571,0.049742863,-0.0029550146,0.027317405,-0.120297186,0.020865515,-0.045250755,-0.034549266,0.01583974,-0.012239394,-0.034236822,-0.09675394,0.03228545,-0.03269474,-0.060174245,-0.07412526,0.075770885,0.0811328,0.012425487,0.07426702,0.015033561,-0.026650677,-0.0014112623,0.05591811,-0.0048841657,-3.5707195e-08,0.06638947,-0.16365801,0.011744185,-0.056133963,0.012601612,-0.017935205,0.021687401,-0.012108862,0.020178888,-0.04094474,-0.0043740724,-0.01763535,-0.021746362,0.06871413,0.07984643,-0.004108623,-0.10781004,0.059481245,-0.04145007,0.010059119,-0.06253787,0.042212375,-0.08799469,-0.02487348,0.018587368,-0.015665567,-0.046941835,0.02080471,0.00042985083,-0.02517751,0.0554528,0.06820248,0.0007450471,-0.0833007,-0.12263715,0.044760987,0.024378732,-0.046364635,-0.07177694,-0.0004458622,0.06801293,-0.027085867,-0.015045284,0.034084365,-0.059254967,0.028131384,0.028817257,-0.054058705,0.03406331,-0.07452832,-0.017377757,0.06655608,-0.009145175,-0.035862975,-0.07020195,-0.012429034,-0.07566607,-0.072888054,-0.023413943,-0.05839104,-0.025631968,0.05877393,0.11756904,0.03004132 +5.4.4.4,"In absence of oxygen the bifunctional linalool dehydratase-isomerase can catalyse in vitro two reactions, the isomerization of (3S)-linalool to geraniol and the hydration of myrcene to (3S)-linalool, the latter activity being classified as EC 4.2.1.127, linalool dehydratase. 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Achilleol is an isomer of camelliol C with a 4-methylenecyclohexanol ring system. This enzyme probably evolved from EC 5.4.99.39, beta-amyrin synthase. 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+5.4.99.39,"Some organism possess a monofunctional beta-amyrin synthase [3,4,6-11], other have a multifunctional enzyme that also catalyses the synthesis of alpha-amyrin (EC 5.4.99.40) [5] or lupeol (EC 5.4.99.41) [6].",384,0.99999994,-0.059207946,-0.16510063,-0.05855504,0.013661981,0.041525643,0.0029911487,-0.006599374,-0.018931828,0.10510437,0.009091306,-0.030369412,-0.008388057,-0.1395427,-0.008590828,-0.032546706,0.071069695,-0.16525346,0.03538565,-0.050839555,0.035656136,0.019178879,-0.04537136,0.0069204476,0.07077047,-0.028899113,-0.021018172,0.03237806,0.0013653103,-0.024071962,-0.033742715,0.0760876,-0.0055168294,0.02812179,0.041455057,-0.03257239,0.032648575,-0.08967013,-0.159842,0.05594996,0.0049738744,0.029263366,-0.008048586,-0.037225477,-0.08329003,-0.02854308,-0.04457433,-0.07651984,-0.020574471,0.030515578,-0.06543895,-0.015494242,-0.09720923,-0.0732953,-0.023606185,0.026107145,0.026095662,-0.055883076,-0.06741509,0.020346886,0.06921029,-0.029240083,0.076413065,-0.0006800664,-0.012244006,-0.0139360195,0.022415858,-0.033064883,-0.076004274,-0.042885613,0.00042453888,-0.085912414,-0.06085116,0.012058895,0.00940307,-0.00014573892,0.004571401,0.052231707,0.013467755,0.0034863492,-0.018461768,-0.0009928718,-0.005739228,0.022379875,0.012074419,0.051385477,-0.036904808,0.03450219,0.035404284,0.0022733845,0.0722993,0.021560716,0.020685451,-0.015484171,-0.07085823,0.030203722,0.035597395,0.0019789368,-0.03405575,0.06924828,-0.022592576,-0.019717477,0.056960672,0.048869915,-0.07381381,0.022721058,0.010394428,0.041355297,0.079509154,0.02922333,-0.04636374,-0.010450116,-0.03384499,0.061480545,0.057260755,0.01305526,-0.020895028,-0.051647525,-0.053634495,0.009407037,0.035853233,0.03012266,-0.020238256,0.10155177,0.062620476,-0.047431394,0.0304966,-0.099375114,-3.9032295e-34,0.11248652,0.011008339,0.008555402,0.015016981,0.041366454,0.03979656,-0.035663083,0.020019453,-0.058439877,-0.039589647,-0.06443776,-0.023706565,0.0015365594,0.07190292,0.103085294,0.012309307,0.022417523,-0.0005369079,0.07034773,0.032238517,-0.010675329,-0.009424028,-0.024923105,-0.031146403,0.07290376,0.028823644,-0.09009269,0.04097144,0.057524398,-0.0051464126,-0.01364113,-0.033883646,-0.074144915,0.1034351,0.03226865,0.08270325,-0.025278494,-0.014201255,0.0012324919,0.022362648,0.09181832,-0.025532003,-0.017358392,0.025239335,0.091541134,0.043349955,-0.067616284,0.009134873,0.032916497,-0.0053134137,-0.01577471,-0.02127956,0.08804527,-0.09095932,0.0036203691,0.036537033,-0.04938632,0.026061837,0.07468705,0.079515375,-0.06812747,0.08090045,-0.051101986,-0.007524186,0.014826205,0.0634091,0.013393237,-0.077206366,-0.032086518,-0.0053673647,0.029582957,-0.059861284,0.069190316,-0.017716998,0.03285505,-0.006872165,-0.03461597,-0.06798619,-0.022717083,-0.006309566,-0.019324884,0.058773976,-0.016625898,0.024565088,-0.029309127,0.007081805,-0.025201533,-0.006827246,-0.016244028,0.050597645,0.018979607,-0.086980395,-0.055997264,0.0029842483,-0.02166276,-1.7344827e-33,0.06128806,-0.17257,-0.063615166,-0.05358855,-0.06305994,0.0777096,0.052550122,-0.121777974,0.0038459804,0.02877264,0.07313032,-0.023819325,0.022555409,-0.078714564,-0.044271808,-0.019011656,0.014497753,0.035879873,0.057863932,-0.014659716,0.006583419,0.077759504,0.076296605,0.034075614,0.03982154,0.017393375,0.020426087,0.059783652,0.006660504,-0.03458257,-0.065127425,-0.023173248,0.06392136,-0.08016345,-0.032848004,0.028120937,0.0040872805,-0.030876586,-0.010564967,-0.008467126,0.010899518,-0.008298114,0.038915846,0.067923084,0.093156815,0.030981062,-0.016162712,-0.008525305,-0.021070894,0.011487058,0.031009309,-0.07314487,-0.02495101,-0.011185588,-0.026682327,-0.015981624,0.0597605,0.012470562,0.023799783,-0.03815714,-0.05197278,0.0027630045,0.06447507,0.038527504,0.024444476,0.06642914,0.00684768,0.02549085,0.053066626,-0.06538656,0.08238001,-0.007957299,0.015912833,0.059764054,0.02233812,0.036470126,-0.085588925,-0.04997433,0.048890036,-0.02104949,0.0019080709,0.010593978,-0.046577718,0.007678457,-0.11715309,-0.113016136,0.080850564,0.08430165,-0.02726704,-0.01836472,0.026017698,0.036888234,-0.038165398,-0.007983801,0.033962257,-3.7843563e-08,0.08040693,-0.0016736977,0.046592385,-0.07435349,0.075433224,0.009141817,0.083993144,0.0029483975,0.0044778595,0.018256566,-0.090074085,0.06343873,0.03200098,0.008514774,0.035754,-0.039034132,-0.034312256,-0.007494829,-0.018932693,-0.04927756,-0.000113860064,0.091794126,-0.052561168,-0.0323265,-0.014556566,-0.1371239,-0.04630673,-0.023189126,-0.06630026,0.028822517,0.0051221317,0.065602034,0.020194612,-0.053816214,0.035992153,0.0050894953,0.007428302,-0.08705922,-0.0112702,0.043525726,-0.047390644,-0.05584831,-0.01953353,-0.05849381,-0.026477579,0.01698998,0.036387507,-0.02360839,0.08976041,0.01190847,0.060964614,-0.0052049807,-0.023777997,-0.06260394,-0.077823445,-0.064758256,0.009431802,-0.09902352,0.032654587,0.0051647993,0.024390945,0.025306389,0.16261475,0.0146488175 +5.4.99.40,"A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39, beta-amyrin synthase).",384,1.0,-0.08595404,-0.104675874,-0.10788091,0.04143055,0.018475473,0.0035062323,0.017772779,-0.053631406,0.078582846,-0.03611797,0.018241882,0.003426682,-0.121821,-0.009633698,-0.07070727,0.06675402,-0.14659001,-0.0059169163,-0.04929762,0.00095825497,-0.049205817,0.0012327218,0.012210375,0.10119409,0.031870343,0.0030982175,0.0035244557,-0.030822616,-0.0146368,-0.010175897,0.059160408,-0.031463202,0.026221944,0.04455856,-0.05610252,0.04607348,-0.085471824,-0.10906491,-0.002464168,-0.026879111,0.018582506,-0.048029073,-0.03608131,-0.03943675,-0.028298164,-0.051767576,-0.07326469,0.01803712,0.05609922,0.0029321548,-0.024429034,-0.12170079,-0.07655863,-0.01687829,0.032208502,0.054488797,-0.060942497,-0.06298178,-0.05413644,0.0900566,-0.028149853,0.056226734,-0.023171393,0.03669217,0.021725597,0.009466955,-0.02007743,-0.051905587,-0.012170372,-0.043409154,-0.06856419,-0.10063146,0.010685478,-0.0025992156,0.0016052645,-0.039373174,0.015661152,-0.011707064,0.09604972,0.0091555705,0.01702017,-0.011452746,-0.00012787512,0.050576482,0.035087213,-0.011008754,0.0408843,0.019175617,0.01786256,0.059508324,0.040561333,-0.00038503853,-0.005202054,-0.03825877,0.014928884,0.018564625,-0.037675858,-0.025479138,0.052583203,0.001407771,-0.030726416,0.08309525,0.05912005,-0.08861596,-0.007377579,0.0020127422,0.01537616,0.041872118,0.05255903,0.0024056563,-0.01323863,-0.035169687,0.02337789,0.026199806,0.013328975,0.075472146,-0.045747105,0.0025660913,0.021819955,0.030068422,-0.008870527,0.0067773107,0.057408445,0.07106776,-0.054519415,0.03063503,-0.075197875,-2.0327223e-33,0.08756151,0.051285643,0.020348456,0.02509397,-0.014477579,0.04323002,-0.10080765,-0.022083275,-0.025149489,-0.042679824,-0.025952114,-0.07242396,-0.035367645,0.0893953,0.12258004,-0.035802282,0.0071851383,-0.0039987955,0.101025246,0.033150632,-0.037747383,0.083530106,-0.04780918,-0.025240699,0.04789503,0.012664353,-0.05782444,0.09024891,0.03586272,-0.012051299,0.060965892,0.024833882,-0.08086057,0.031664602,0.033598945,0.044034116,-0.047222946,-0.018531173,-0.009476538,0.08384511,0.04725683,-0.02983651,-0.009560518,-0.0032758627,0.08284297,-0.025764193,-0.037417028,0.050241698,0.01881688,-0.013974495,-0.021901386,-0.0014138817,0.10372686,-0.07590735,-0.00083496666,0.020655159,-0.02218426,0.014164855,0.041013546,0.058654614,-0.052637033,0.05739114,-0.03044265,0.008004856,-0.03618516,0.024735397,-0.0038725745,-0.06403213,-0.025116583,-0.015626498,0.037331697,-0.025791137,0.1006043,-0.03658119,0.010338263,-0.026041083,-0.049377866,-0.038748764,-0.01187441,-0.058504585,-0.10302202,0.0024242976,0.006706797,0.030176379,-0.0034622133,0.034166213,-0.00781493,0.023089884,-0.0090013,0.007932807,0.0012277314,-0.025456095,-0.060714345,0.011919613,0.01730761,-9.126314e-34,0.048070915,-0.18139772,-0.05878439,-0.048484266,-0.035143137,0.041665673,0.0349777,-0.10010671,0.024331946,0.06843013,0.031031651,-0.0114384275,0.031624984,-0.095953695,-0.025502361,-0.012566282,-0.0062290123,0.021058453,0.032987922,0.01994561,0.03251323,0.08084267,0.091306604,0.021738352,0.04055283,0.0031420805,0.0690434,0.040994033,0.011841132,-0.0025762508,-0.059280843,-0.06852175,0.050664596,-0.09675149,-0.036647942,0.06655373,0.03582971,-0.053532954,-0.045572784,-0.025477355,-0.0023880634,0.03304405,0.027735032,0.08658686,0.07065514,0.043885395,-0.0027051864,0.016083939,-0.06749861,-0.02537335,0.016227318,-0.014142841,-0.011335054,0.005679619,-0.051592056,-0.0031175527,0.0016893642,0.020662384,0.0038537348,-0.041020967,-0.025041796,-0.025902662,0.05843465,0.020387271,0.010322036,0.033376303,0.018555608,0.050839137,0.023761766,-0.0224755,0.07536334,0.021151561,0.032212764,0.08632349,0.011530188,-0.010477949,-0.053384732,-0.07630453,0.076808035,-0.046435338,-0.04719591,-0.016348636,-0.060854167,0.05084453,-0.07801926,-0.10234318,0.09053039,0.10614971,-0.015553059,-0.009754808,0.025575483,0.071726955,-0.09918092,0.021544874,0.022753721,-2.4389454e-08,0.10338478,-0.069219306,0.022421654,-0.098227054,0.086325474,-0.016741134,0.061700594,-0.029206662,0.006211629,0.0028549375,-0.068854846,0.1278143,-0.0028417748,-0.023012092,0.019938692,-0.06122077,-0.029380724,0.0520247,-0.037105076,-0.082184784,0.0039568217,0.069884315,-0.018445048,-0.03561805,-0.0011610164,-0.12971307,0.004913131,0.03906374,-0.074744485,0.01286448,-0.000713544,0.051509406,0.009605052,-0.104783274,0.010643655,0.09564039,0.03981,-0.06435106,0.023398066,0.029392209,-0.09328697,-0.09350533,0.031725675,-0.029012479,-0.007660138,0.0028078018,0.044703502,-0.027344653,0.10595922,0.021553157,0.049466107,-0.0014974108,0.010207073,-0.055919364,-0.059551578,-0.018202126,-0.030993283,-0.08313636,0.03861878,-0.004218671,0.05718009,0.019000722,0.13989931,-0.010203632 +5.4.99.41,"Also forms some beta-amyrin. The recombinant enzyme from Arabidopsis thaliana [3] gives a 1:1 mixture of lupeol and lupan-3beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol. See EC 4.2.1.128 (lupan-3beta,20-diol synthase).",384,1.0,-0.092405714,-0.14148615,-0.049093127,0.00809636,0.07098031,-0.011685721,0.0092803165,-0.036061767,0.09193753,0.01832753,0.057430416,0.015571053,-0.1373688,-0.05991578,-0.029870896,0.06699479,-0.09033694,0.0644816,-0.06257073,-0.036786977,0.034837373,-0.014539483,0.021068346,0.04916914,0.056782648,-0.030692086,0.038913496,0.022756107,0.0002772505,-0.063734785,0.054267365,0.053440306,0.027242735,-0.0047458536,-0.05226815,0.068506524,-0.030147482,-0.14011368,0.042461082,-0.031885482,0.049502272,0.0021534562,-0.044829063,-0.00283265,-0.04879386,-0.08003013,-0.100303374,0.054454073,0.06622988,-0.071656525,0.021954626,-0.04318377,-0.01582654,-0.006531155,0.015716266,-0.009055665,0.01127873,-0.014648759,0.04237018,0.08185188,-0.035875592,0.0742418,-0.060433276,-0.035074506,-0.06934241,0.025370331,-0.060944486,-0.03719847,0.031307675,-0.0014855011,-0.08549499,-0.04501656,0.00876564,0.008217221,-0.010676414,0.040748794,0.041792583,0.016463764,0.012488878,-0.024336675,0.009886175,-0.007965119,0.09829049,0.039214026,0.04603904,-0.023383325,0.011399475,0.04700966,0.05385749,0.04260906,0.00096973643,0.019975768,-0.03396778,-0.024882512,0.04734697,0.11440599,-0.006005494,-0.061815225,0.035193786,0.0011342579,0.0029137346,0.014379329,-0.003729475,-0.13269518,-0.041978613,0.06331153,0.044936053,0.022954298,-0.020056287,-0.020229176,-0.0004798964,-0.008259361,0.05189178,0.037435524,-0.046658646,-0.027964924,-0.012062315,-0.0713509,-0.015930485,-0.021717144,0.009399568,0.0015487415,0.042399824,0.023307618,-0.063666664,-0.015387371,-0.09693325,3.437607e-33,0.07604917,0.045254644,-0.07372123,0.04673746,0.04577408,0.004316498,-0.050979137,0.07167928,-0.066590674,-0.076659516,-0.1024927,-0.04785524,-0.02479362,0.004467136,0.05148739,-0.020812945,0.017765125,0.0058994405,0.10921285,0.04340812,-0.04532888,0.004788493,-0.068625785,-0.061038014,0.026343146,0.01927762,-0.079405606,0.022602458,0.07094731,-0.016863484,0.033030067,-0.06066431,-0.0017155629,0.11096703,0.013524721,0.072235964,-0.058191482,-0.041910797,-0.0067804954,0.037048697,0.106152944,0.039034624,-0.0021857445,0.055683795,0.02081207,0.068162195,-0.0030394264,-0.0389032,0.02925424,0.074786164,-0.007180936,0.018575296,0.09268624,-0.07131387,-0.04938038,0.037371125,-0.020485574,0.0124833705,0.078491546,0.08124093,-0.11641412,0.09368009,-0.020755697,-0.005962314,0.007552923,0.03709884,-0.047075503,-0.041079387,-0.0499119,-0.007057999,-0.044300385,-0.043920856,0.04483158,-0.040173084,0.044712827,-0.0075224647,0.0015798878,-0.02028788,-0.01999147,-0.034304697,-0.006741872,0.00695383,-0.0029341665,-0.0033054827,-0.023254594,0.023476688,-0.040186353,0.0011049183,-0.01522945,0.025096487,0.06167042,-0.082022525,-0.036922086,-0.011003213,0.038828332,-3.4969293e-33,0.012905928,-0.07999841,0.011055646,-0.043175187,-0.05743499,0.056636475,0.079182476,-0.08942764,0.039488815,0.044236105,0.07089653,-0.037708484,0.013517545,-0.056305993,-0.06427418,0.033320505,0.029106632,0.06171522,0.020989913,0.011722831,-0.014652119,0.12475105,0.10598169,0.0021417248,0.019297803,0.020085394,0.0863985,0.08485148,0.022630623,-0.053375628,-0.0064430255,-0.042646896,0.05818161,-0.09252639,-0.08435698,-0.013798786,-0.032271788,-0.06320695,-0.0014009661,-0.012679998,-0.0113283545,0.02095228,0.018348413,0.056547504,0.04145768,0.0378257,-0.010819235,0.0069782077,-0.028850606,0.0056616412,0.029903254,-0.016640386,-0.058811534,0.068003505,-0.008135688,-0.0429074,0.06358147,0.040512927,-0.033130094,-0.0007595427,-0.029186064,-0.02617611,0.020267876,0.046814255,0.0970106,0.058984354,0.039719466,0.06729498,-0.0028552557,0.010323091,0.11824084,0.002862229,0.024129849,0.097891964,0.035918187,0.00039183325,-0.036854558,-0.03854178,-0.0056344843,-0.029611407,0.03718944,0.005432554,-0.076319546,-0.045402296,-0.058508027,-0.12313599,0.044118214,0.09842391,-0.024994517,0.032899275,0.019932294,0.024280686,-0.020715704,0.047673024,0.1199761,-3.767194e-08,-0.0016233693,-0.04263941,0.011866359,-0.08225282,0.020714479,-0.006020521,0.08193795,0.036795743,-0.007839862,-0.0030389198,-0.07283353,0.09440532,-0.014418064,-0.0015764191,0.03687842,-0.021021944,-0.039983954,0.024192888,-0.0069383136,-0.054729994,0.019460106,0.09013597,-0.052950244,-0.0103240535,0.0094040735,-0.10430267,0.001358425,-0.038056623,0.0028782128,-0.032405224,0.011389877,0.0538555,-0.009014358,-0.09805811,-0.04319633,0.028798763,-0.06316974,-0.05131031,0.012793324,0.016807368,-0.02041269,-0.019400379,0.0038623742,-0.043125454,-0.037157603,-0.0064536836,-0.00016396979,0.01971053,0.104008935,-0.0042507653,0.09253924,0.011937319,-0.0026231343,-0.13403843,-0.09791601,-0.079679914,-0.02236059,-0.063822776,0.05842744,-0.035222217,-0.025555365,-0.026654419,0.10667486,0.008643456 +6.2.1.37,"The enzyme works equally well with 4-hydroxybenzoate but shows low activity towards benzoate, 4-aminobenzoate, 3-aminobenzoate, 3-fluorobenzoate, 4-fluorobenzoate, 3-chlorobenzoate, and 4-chlorobenzoate. There is no activity with 3,4-dihydroxybenzoate, 2,3-dihydroxybenzoate, and 2-hydroxybenzoate as substrates. ",384,0.99999994,0.057939015,-0.107947305,-0.035941955,-0.09026206,0.045275267,0.04605403,-0.004421675,0.033148646,7.765032e-05,-0.048760314,-0.014048815,-0.037934676,-0.01230094,0.16378678,-0.05349152,0.107714556,0.033913832,0.035847794,0.010168474,-0.01623806,-0.028088743,-0.09125499,0.08619215,0.011686807,-0.0051010903,-0.042471386,0.04317646,-0.033935998,0.012497304,-0.08086381,0.009300204,0.003516399,0.021607678,-0.039314903,0.056713548,0.09326501,-0.0303998,-0.08173251,-0.020055676,0.0746612,0.024768677,-0.0040480117,-0.034313805,-0.021972422,-0.0389225,-0.052493624,0.059564497,-0.027354324,0.039599657,-0.015645945,-0.071896195,-0.046791457,0.04076805,0.0310077,-0.10024693,-0.0112937875,-0.009815359,0.051102582,-0.07098743,0.056162626,0.029842613,0.027543452,-0.009609051,-0.004507189,-0.03535914,0.039637078,-0.028762573,0.011649628,-0.03746111,-0.018105447,-0.082964875,-0.05956563,0.0044696066,-0.04189043,-0.02728024,-0.039503455,0.0036352226,-0.005383237,0.018858815,-0.081164725,-0.023923792,-0.09256401,-0.0028437143,0.09110539,0.035680294,0.06070162,-0.051947225,-0.018638331,0.092398904,0.045963205,0.035886794,0.10690542,-0.033219177,-0.018676678,-0.041307632,0.06451017,0.0134823695,0.04365288,0.01902322,0.030651873,0.08182485,0.026019191,-0.037453227,-0.074972466,0.009821268,0.069817245,0.026822615,0.073843576,-0.041463155,-0.019112106,-0.04982165,0.023343775,0.06743899,0.039897963,-0.048707306,0.034778632,0.060941193,-0.058610715,-0.04632545,0.06282958,0.028810143,-0.033471324,0.1292416,-0.04112865,0.026776174,0.13375153,-0.08748055,5.1525925e-33,0.06415306,0.016878963,0.0146733895,-0.0054238294,-0.021383688,0.06121948,-0.06490767,0.034135822,-0.09954408,-0.057922795,-0.03959536,0.05663145,0.040393047,-0.035671607,0.020967206,-0.031656407,0.04778736,0.032505486,0.04142067,-0.0038417578,0.06782959,-0.028773895,-0.07288853,0.03601574,0.01197602,0.04691164,-0.0007044425,0.03495156,-0.02217193,-0.0021394512,-0.0877734,-0.011667362,-0.07463005,-0.063504025,0.026506951,0.038930707,-0.07701346,-0.009817807,-0.021290487,0.0105356565,-0.014068478,0.011913881,0.03284846,-0.09010043,0.04715864,-0.030814728,-0.006456185,0.12081856,0.036546998,0.07424283,0.05926765,-0.055152193,0.026012529,-0.03717037,-0.013160774,0.056174263,-0.05071747,0.037360657,0.08312333,-0.009035135,-0.043176036,0.026911335,-0.111141585,-0.015818655,-0.007309396,-0.034938674,0.021776676,-0.021853969,-0.07517298,0.045468666,-0.016517079,0.0025797114,0.04076562,0.09120059,0.092899196,-0.117886685,-0.031561125,-0.08192206,0.11947549,-0.021906856,0.04096689,-0.047703814,0.0688441,-0.013934936,-0.099744536,0.0047052177,-0.010354182,0.023910936,-0.037507378,0.04773792,0.056491762,-0.09497579,-0.005296139,-0.019730069,0.0022783591,-4.6851256e-33,0.031888187,-0.00091612776,0.041890062,-0.034506466,-0.011628705,-0.01133271,0.06585003,-0.046458304,0.080335476,0.04441291,0.08147011,-0.054003477,-0.04753432,-0.047936544,0.019420791,0.06199007,0.011494611,-0.022397678,0.04209452,-0.008542414,-0.03883157,0.04733129,0.000689927,0.051905073,0.005684129,0.020172283,0.05060019,0.046445917,0.039417904,0.047426622,-0.05879318,0.025032235,0.021065164,-0.024121761,-0.023160353,0.052346814,-0.10730954,0.020460578,-0.01367258,-0.01440527,-0.03201513,-0.0033937092,-0.02984592,0.046926048,-0.04244882,0.09352674,-0.11976732,0.0018476017,0.008674116,-0.042437095,-0.026197404,-0.02886294,-0.03796628,0.039731972,0.024641272,0.024159642,0.025272507,-0.054109097,-0.061602317,-0.0063262056,-0.02764189,-0.0015118084,0.009497046,0.020901436,0.057155963,0.029589288,-0.061855797,0.0896805,0.025782585,0.0014601494,0.058061387,-0.0128510175,0.08014361,0.04537464,-0.06648288,0.062806524,-0.032620985,-0.028978217,-0.06260383,-0.05298938,0.07080288,0.052267905,0.009988391,-0.09996097,-0.085472845,-0.045777857,-0.022382718,0.041549332,-0.015387999,0.05689255,0.01759797,0.057201542,0.01772826,0.040169016,0.057329502,-4.6421974e-08,-0.008529566,0.0013318959,0.09436792,-0.089167014,-0.053852074,-0.012748168,0.0029793875,0.021741508,0.053346053,-0.014901314,-0.07086167,0.013522048,0.000981426,0.059699558,0.05459994,-0.010091911,-0.013699636,0.012329795,-0.063880466,0.012743645,-0.057779215,0.06756165,-0.10572891,-0.009543015,0.0038043512,0.0067167343,-0.0017390008,0.049317677,0.024116794,-0.056452688,-0.029619675,0.058564644,0.021630716,0.0084838625,-0.07479303,0.03245608,-0.029008623,-0.02164548,-0.12605153,0.032798972,0.047861118,-0.08609932,-0.08600608,-0.014750038,0.0637664,-0.035726972,-0.022710243,-0.035262793,0.06368175,-0.03946784,0.054445818,-0.009596058,-0.027710965,-0.041936938,-0.013156458,0.025366034,-0.0076322667,-0.0658171,-0.034572117,-0.133894,-0.0026588102,-0.04764581,0.101534314,0.0017530438 +6.3.4.19,The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34. This modification determines both codon and amino acid specificities of tRNAIle. ,384,0.99999994,-0.102033,-0.05573767,-0.069970846,-0.082655594,-0.01950101,-0.0439996,-0.0010277303,0.07983064,0.014159889,0.036420394,0.080440655,-0.057815935,-0.0036025003,0.027843174,-0.07558536,0.005098909,-0.07964364,0.042730357,0.011861396,-0.03977445,-0.004248432,0.061800666,-0.021175051,0.042981286,-0.050315905,0.040446367,-0.04082774,0.029605234,-0.025712641,-0.05667879,0.00032258092,0.05184986,0.15536334,-0.0633505,0.08569965,0.0019993326,-0.015094093,-0.059495986,0.111602284,0.044309303,-0.005406863,0.092204355,0.05576836,-0.03039174,-0.0007713926,0.0046167276,0.008375101,0.043390326,-0.010224887,0.09670984,-0.018701786,-0.021679185,-0.02873229,0.04081784,-0.0008635654,0.11072624,-0.033220176,0.044444833,0.002762247,0.010524949,0.05503021,0.027973976,0.03696064,0.022419272,0.043375228,-0.07566469,-0.016903104,-0.029193658,0.031421103,-0.017886193,0.031708743,-0.005441741,-0.009268005,0.04620058,-0.0180625,0.026823783,0.015644738,-0.070047736,-0.012402978,0.027805733,-0.05068162,-0.019417632,0.046972822,0.038515564,0.04160207,-0.031705827,0.056945916,-0.026455853,-0.028583487,0.07746313,0.07952687,-0.0072997003,-0.009883105,-0.04174406,0.020533029,0.0016221202,0.042055286,-0.016141886,-0.029509915,-0.017751763,-0.020908577,-0.010019018,0.009191519,-0.051500596,0.06359269,-0.027140314,-0.0030245387,0.015798902,-0.03393586,0.010664719,0.022145614,0.039097823,0.009505534,-0.03343073,-0.05886868,0.029908989,0.024310015,-0.026011262,-0.04299647,-0.06383462,0.0049653626,-0.029507672,-0.019358668,-0.016979566,-0.00068241643,-0.03735821,-0.06153301,1.5908404e-33,0.013057762,-0.038886674,-0.033729877,-0.07393882,0.013628955,-0.047621325,-0.07113167,0.049382053,-0.026023623,-0.08810872,-0.07291245,-0.045277093,0.074313745,0.03709919,0.015542991,-0.028448503,-0.045652214,-0.004375925,0.008987326,0.02511102,0.05047429,0.060525276,0.008306466,-0.048134733,-0.000684068,0.08949349,-0.09236542,-0.059084054,0.013843753,0.020928523,0.0073008873,-0.017259294,-0.0747089,-0.0179343,0.08920623,-0.012907871,-0.00917305,-0.044043504,-0.05207061,0.040536363,0.015033715,-0.0038851814,-0.010310227,-0.046018332,0.035901252,-0.045588706,-0.048321005,0.02905366,0.0029411232,0.075758874,0.057477843,-0.017297108,0.018633964,0.028554482,-0.040741242,-0.014894997,0.0063444534,-0.055533715,0.00019015603,0.035719387,-0.0003504929,0.014651775,0.0057699266,0.005259834,-0.054170795,-0.026277175,-0.040116183,-0.08606027,0.0109103555,0.0774857,-0.027674096,-0.05792655,0.06362357,0.012350058,-0.015180003,-0.009358112,-0.039634034,0.0054749395,-0.0071083,-0.010789978,0.06233624,0.011149146,0.026402025,-0.028397938,-0.08969541,-0.020833991,0.046808403,-0.00828124,-0.011204061,0.10475922,0.019800277,-0.09805303,-0.049092855,0.021176105,-5.661539e-05,-3.3672032e-33,0.07170613,-0.103737585,0.004513053,-0.0570034,-0.14592028,0.07426877,-0.049551923,-0.07527172,-0.038730808,-0.094823495,0.06488354,-0.013168193,-0.102988504,0.023574537,0.024312353,0.016453372,-0.02443631,0.06516211,-0.052605953,-0.058268927,0.03983873,-0.037109848,0.01844688,0.03247251,0.10018031,-0.014064526,0.042808183,-0.009418547,0.024332795,0.05619965,-0.11925372,-0.039075162,-0.014530855,0.033252653,0.005895975,0.112531714,-0.053506248,6.27424e-05,0.04339325,0.0028355415,0.03719899,-0.02679428,0.045123078,0.086631484,0.01124746,0.052354477,-0.02061095,0.035402283,-0.06518278,0.06383161,0.11473802,0.012382511,0.06077385,-0.018579772,0.08650209,0.026049858,-0.064911634,-0.020600038,-0.10247684,-0.025690492,-0.037987363,-0.06645746,-0.06568044,-0.040733982,0.06606614,0.050087754,-0.06702383,0.06259487,0.008504225,-0.064017475,0.008884891,-0.025814913,0.09302257,-0.022831772,-0.011127759,-0.07308015,-0.05467495,-0.030421592,0.03648169,-0.01745559,-0.098869234,0.005875689,0.04000937,-0.012348929,-0.017304342,0.028650736,-0.05893796,0.062202137,0.012555813,0.035428416,0.017245917,0.017828733,0.04481197,-0.02356247,0.09727938,-3.030258e-08,0.040760227,-0.07232561,-0.015213865,0.031086572,0.03725333,0.099896826,-0.0076908846,0.01528502,0.045321908,0.0106390035,0.07078226,0.09598381,-0.04547781,0.014133791,-0.007495545,0.10690405,-0.16468203,-0.055397633,-0.012416591,-0.0075738686,-0.13186716,0.03896637,-0.12878713,-0.00041603734,-0.03015749,-0.030912654,-0.0037501403,0.044311535,-0.06795949,0.025319524,0.080743514,-0.04117294,-0.06633442,-0.054422207,0.014545792,0.01112047,0.037441567,-0.05258465,-0.023044767,0.032251697,-0.01888973,0.06306203,-0.12953581,0.00581508,-0.006826604,0.04491106,0.013633926,0.08239014,-0.0233145,0.0038915172,-0.015220943,0.05882694,0.037922245,0.019733595,-0.10437892,0.07754581,0.035343867,-0.07851522,0.0010878262,0.092371605,-0.0204044,-0.010046462,0.16362831,0.03285568 +1.3.1.89,A flavoenzyme. The enzyme specifically modifies uracil47 in tRNA. ,384,1.0,-0.082598895,-0.05132154,-0.08203339,0.007095957,-0.0081208125,-0.022117235,0.000510602,0.020426605,-0.005332731,-0.005639596,-0.010014742,0.019622823,-0.06285472,0.021856735,-0.08958407,0.015287131,-0.087945476,0.030946286,-0.011626431,-0.03581037,0.059947994,0.06131445,0.011244521,-0.0024748745,-0.0022891695,-0.009223823,0.06544262,-0.04666439,0.009400292,-0.10192925,-0.018858872,0.0019490564,0.0038334155,-0.06517749,-0.011181504,0.03577423,-0.16468027,-0.06997628,0.051098876,-0.012991477,0.059632905,-0.01122667,0.017530113,-0.0018413021,0.007719772,-0.0390608,-0.021149475,0.06590856,0.0074931625,0.1010264,-0.041471362,-0.012364074,-0.053433385,0.012414147,0.0064379377,0.004305416,-0.0947556,-0.011643495,0.0056099906,-0.024259511,0.043292876,-0.0040853727,0.028944217,-0.060325827,0.06456021,-0.04025812,-0.02829222,0.015532279,0.053540565,-0.052847352,-0.022339594,-0.020240087,-0.0090532955,0.10930926,0.0035534531,0.021327183,0.010116009,-0.04996395,0.021991571,0.053603552,0.01686635,-0.070593424,0.008839744,0.11466454,0.09078759,0.006710727,0.0050125574,0.01621606,0.0031650465,0.08271531,0.055336464,0.052914727,-0.024896897,-0.021380307,-0.050069902,0.021230925,-0.00971474,0.048100736,-0.068209335,-0.02248623,0.0023820747,0.0061761388,-0.012475342,-0.079669036,-0.07287224,-0.034364764,0.026494721,0.032696653,0.011072142,-0.010228517,0.008484337,0.023986526,0.05454479,-0.045532662,-0.036036287,0.053030387,-0.0062872684,-0.029865984,0.0051423986,-0.012196727,-0.039832618,0.05821302,0.048211787,0.04014982,-0.0639398,0.0075359554,-0.054148503,3.4976407e-34,0.003597301,0.023211945,-0.039167173,0.0334888,0.08896469,-0.026500579,-0.01304997,-0.018766603,-0.070806585,-0.08253882,-0.14009273,-0.049006738,0.0006413482,-0.07976943,-0.017664822,-0.0078019076,-0.041053936,0.003841047,0.032067813,-0.057682157,0.03999085,0.11477764,-0.019027121,0.040903796,0.044163726,0.006092833,-0.027238496,0.03089081,0.01091349,0.014356279,0.029062238,0.012504188,-0.06238671,0.009914904,0.084644794,0.018119581,-0.041146204,-0.074994445,-0.1398294,0.036794253,-0.028674679,-0.0018068627,-0.010239079,0.026423333,-0.008711614,-0.08134298,-0.047176104,0.08796627,-0.031519324,0.0637356,-0.007933342,-0.02334869,0.081604,0.015910497,-0.05413761,-0.032009196,-0.055002525,-0.036201745,0.05808402,0.06743833,0.031692766,0.0800685,-0.010030101,0.10634181,-0.016449036,0.0067328806,-0.011630951,-0.052834302,0.027939985,0.069253504,0.004039304,-0.043183643,0.099980555,-0.029722817,0.03666105,-0.04648444,-0.08865753,-0.0289645,-0.009181664,-0.007641775,-0.0007319206,-0.09292297,0.056762036,0.046114385,-0.03497115,0.021225238,-0.0033781899,-0.017254941,0.026825946,0.055959422,0.10372102,-0.038355004,-0.059614994,-0.0105076665,0.039264385,-2.3647296e-34,0.10346358,-0.117644,0.09286031,0.032716945,-0.034144685,0.0025805861,0.07720507,-0.09877033,-0.008888788,-0.030815406,0.13726625,-0.048730247,-0.04434097,-0.06769927,0.0044298125,0.010015138,0.069095515,-0.02084341,-0.014920357,-0.017483598,-0.059185818,0.039251257,-0.019598955,0.08587578,-0.01944596,0.015948988,0.08556743,-0.03924994,0.0356221,0.008932785,-0.048443444,0.026619168,-0.020944169,-0.01084064,-0.040967576,0.09284004,0.03769994,0.012752177,0.0022597902,-0.02300972,0.014846596,-0.015143877,-0.009618764,0.09659637,0.014428059,0.03496439,-0.06187149,-0.043822993,-0.076328315,-0.06879207,0.14465114,0.033597928,0.041350942,0.04918212,0.07379352,0.0032242495,-0.005497208,-0.0070351176,-0.0092017315,0.045200173,0.01903027,-0.06929935,-0.020203285,0.00026602508,0.10009121,-0.0009795735,-0.07393294,0.09708144,0.04485098,-0.028769262,0.047241062,-0.025266707,0.04976738,0.033111457,0.013728535,-0.047617298,0.004947784,0.028661616,0.0547911,-0.07114151,-0.008868107,-0.01582253,-0.018415643,-0.0062102214,-0.010813069,-0.052702542,-0.009989756,0.106248565,0.01640196,0.099521205,-0.042551886,0.018370705,-0.09208401,0.0022944598,0.054399505,-2.1492502e-08,-0.02164191,-0.051032297,-0.034575824,0.01696131,0.032323033,0.08622887,-0.012652637,0.09030552,0.031525195,0.029355993,-0.04364615,0.07508188,0.04981818,0.030514615,0.03982018,0.010206122,-0.08326821,0.040380437,0.0034973035,-0.012345412,-0.10378087,0.06952647,-0.15523048,0.032855358,0.0090835225,-0.049357165,-0.0061125946,0.063687265,0.0038258703,-0.021302903,-0.0024636367,-0.060879026,0.012947209,-0.021333085,-0.10041664,0.103066415,0.040093288,-0.0657075,-0.03058496,0.054921992,-0.061467174,0.011451999,-0.045523856,-0.015685925,-0.07222343,-0.03563903,0.0075206407,0.04368419,-0.061751742,0.025490243,0.07034927,0.031679433,0.050377022,-0.033187736,-0.034271527,0.0032429264,0.046864934,-0.093772426,-0.038345702,-0.00023700878,0.07512353,-0.0050655524,0.13093837,-0.017835375 +1.3.1.90,A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA. ,384,1.0,-0.07956021,-0.052138794,-0.067175426,0.017869726,-0.004067784,0.010102498,0.0065337825,0.025103401,-0.000877791,0.0047684168,-0.012202718,0.026310332,-0.058040623,0.020217,-0.09274487,0.03709407,-0.10485189,0.02564144,-0.030632826,-0.06745048,0.112037405,0.050061315,-0.006081208,-0.008566041,-0.035600066,-0.036027294,0.04272261,-0.06126274,0.018210849,-0.08326592,0.0026392287,0.015829153,-0.020631148,-0.079338275,-0.029474763,0.03825974,-0.1599379,-0.064929135,0.05435033,-0.009695013,0.05912086,-0.029060068,0.017863264,-0.008714089,0.008159295,-0.0139568765,0.0046237838,0.075134285,-0.0092705805,0.07827222,-0.047402095,-0.029331123,-0.07717298,0.010086599,0.010993657,0.06497972,-0.08359438,-0.004583947,0.0012727962,-0.03502872,0.032276727,-0.020758592,0.044899736,-0.041296933,0.058739062,-0.0142580485,-0.034898724,0.030584779,0.043445267,-0.049025804,-0.011107484,-0.030257497,-0.011425446,0.11335847,0.0021889254,0.027376952,0.010187549,-0.017887736,0.013941813,0.049824044,0.03234773,-0.098209225,0.0353133,0.07117152,0.07593892,-0.0029605492,-0.018194566,-0.0091124885,-0.0012834694,0.08041669,0.053049583,0.058225114,-0.0025551596,-0.009908153,-0.05936276,0.018189775,-0.0055129817,0.027008815,-0.05803555,-0.028939737,-0.016164642,-0.0046152626,0.0023530598,-0.0637383,-0.080991425,-0.048869044,0.049795814,-0.005235575,0.019540004,0.0033966443,0.022863803,0.03276996,0.051286045,-0.030601878,-0.033167966,0.044150937,0.004916832,-0.017932132,0.018185465,-0.023482572,-0.0558707,0.06553423,0.03774904,0.045424134,-0.0923294,0.00642504,-0.07939633,2.3551551e-33,-0.017900836,0.027159669,-0.038199976,0.045817655,0.08240234,-0.02811261,-0.01026099,-0.020835863,-0.049228173,-0.06572275,-0.118613675,-0.024585266,0.0029531748,-0.047501985,0.0074467235,-0.018360099,-0.060589198,0.03637275,0.033123843,-0.0600039,0.03726597,0.096902475,-0.004635355,0.051622663,0.041562933,-0.0142602185,0.0025161207,-0.0019452877,0.0031047503,0.007940873,0.038263932,0.022603989,-0.07138661,-0.0052863043,0.09726852,-6.5167544e-05,-0.024313927,-0.07105655,-0.13426073,0.037556615,-0.035935335,-0.021343926,0.002556083,0.02534703,-0.013365159,-0.099824496,-0.053967416,0.07286418,-0.038154673,0.0676173,-0.0010099864,-0.031735744,0.053432334,0.0408692,-0.06619815,-0.023737688,-0.039884616,-0.058393657,0.050596587,0.085513756,0.026745787,0.091781,-0.025785917,0.06180299,-0.034971036,0.034734435,-0.004564197,-0.06403276,0.049120624,0.06431023,0.02983569,-0.039921194,0.0983428,-0.0036284025,0.03350694,-0.03540314,-0.09208893,-0.062429305,-0.04212368,0.021873882,-0.021579413,-0.06539822,0.08147615,0.06299232,-0.029949836,-0.010270007,0.010213929,-0.00437225,0.028219352,0.037703,0.0818499,-0.026502972,-0.0269561,0.012576193,0.0502713,-2.5694532e-33,0.10308061,-0.13452359,0.08962395,0.0177604,-0.0027693452,0.0034916834,0.0709813,-0.10589248,0.03339316,-0.0025010123,0.1337346,-0.019631911,-0.027088532,-0.07371805,-0.014243512,-0.0045804456,0.055423863,-0.01078939,-0.0070376485,-0.028202783,-0.043455515,0.065420896,0.017132787,0.07064483,-0.015818393,1.0810456e-05,0.08447963,-0.0005695338,0.048602004,0.025475822,-0.040749338,0.010091262,-0.011118344,-0.012695404,-0.04705899,0.08683661,0.024796372,-0.005047701,-0.001512282,-0.029938178,0.028317332,-0.007039021,-0.012291283,0.10101321,-0.009323045,0.04195771,-0.07779476,-0.029510682,-0.08300364,-0.05449122,0.14012077,0.031565327,0.04842329,0.047198016,0.02724337,0.009933082,-0.02496464,0.01038832,-0.021613166,0.035681006,0.0122088725,-0.07045536,-0.0013825976,-0.007418133,0.075073056,0.011632852,-0.06331111,0.08425617,0.020018386,-0.0093954345,0.06982026,-0.0011053414,0.019929048,0.053719744,0.011531663,-0.05934833,-0.03951168,0.025808405,0.04681045,-0.08301333,-0.036350872,-0.011710714,5.0980503e-05,-0.018311102,0.020586096,-0.07335031,-0.023233073,0.113171175,0.025387244,0.10025829,-0.042589393,-0.001148726,-0.0963468,-0.030709654,0.06230036,-2.5949875e-08,-0.050298233,-0.034704234,-0.04304825,-0.0008205354,0.040700357,0.058741402,-0.02618509,0.07752244,0.057305828,0.013070668,-0.049293563,0.072638385,0.025660424,0.05264566,0.03324001,0.04578999,-0.09985906,0.05224422,0.016831601,-0.015765041,-0.103298664,0.09009304,-0.15199402,0.02847443,-0.0039202548,-0.052064694,0.008379692,0.05014418,-0.022307672,-0.014243683,0.018468821,-0.053342562,0.00029421295,-0.02149665,-0.10515969,0.115083575,0.04047687,-0.07297342,-0.05215958,0.047636803,-0.067925364,0.006220064,-0.043616597,-0.002337769,-0.055699795,-0.07052961,0.007037096,0.036787763,-0.05549105,-0.015102885,0.06773907,0.03523801,0.016073786,-0.0460169,-0.04453994,-0.0022925008,0.017213939,-0.105910964,-0.032695394,0.033703383,0.07305825,0.013598328,0.12262528,-0.030027127 +1.3.1.91,A flavoenzyme [3]. The enzyme specifically modifies uracil20 in tRNA. ,384,1.0,-0.070265576,-0.057904914,-0.07562853,0.012174662,2.3816929e-05,-0.011040721,0.011583846,0.014484348,-0.003531872,-0.0058849757,-0.0021196178,0.020010892,-0.04828597,0.028938817,-0.10108065,0.013761063,-0.098486036,0.022622947,-0.014921223,-0.060220942,0.09586725,0.04706035,-0.002005713,-0.011337346,-0.02924948,-0.036495797,0.0591204,-0.07402107,0.014220366,-0.06940069,-0.013236225,0.0063790507,-0.020152673,-0.07969577,-0.021386333,0.030139964,-0.17118567,-0.065641835,0.04799789,0.0053091524,0.0640826,-0.02511194,0.022393929,-0.020862484,0.022478633,-0.010746033,0.0044102944,0.06616976,0.0035151166,0.07533417,-0.039523393,-0.0069739805,-0.048540905,0.003130395,-0.0015122679,0.049806014,-0.099840395,-0.0072289747,-0.0103248255,-0.029139884,0.047252048,-0.017036129,0.03826399,-0.062199384,0.050159976,-0.008377439,-0.039150808,0.030359872,0.05450018,-0.01963271,-0.018711593,-0.03025378,-0.021336136,0.101950824,-0.015993336,0.03209254,0.027259829,-0.03142179,0.014816762,0.05870832,0.038383815,-0.09866046,0.048202027,0.079964526,0.05311126,0.007306603,-0.006894114,0.00049342937,-0.0069225575,0.08792989,0.05001177,0.058101162,-0.025463484,-0.007361347,-0.051351618,0.03394451,0.0017206355,0.03207897,-0.06359751,-0.03170642,-0.018299852,0.01611247,0.004192528,-0.07567027,-0.06463919,-0.02900052,0.055174313,0.0002863246,0.016167583,0.008211805,0.012066739,0.02798657,0.050888352,-0.041829877,-0.023624433,0.05144137,-0.0032250937,-0.03610218,0.025894323,-0.011216916,-0.04835251,0.06914885,0.02786858,0.041262798,-0.0850417,-0.002022108,-0.055587925,-5.746728e-34,-0.027769582,0.029320339,-0.04805074,0.040984433,0.09046159,-0.036889423,-0.009087771,-0.025071785,-0.063506894,-0.0767724,-0.11687571,-0.04193237,0.0074457806,-0.056973413,-0.0016274425,-0.010697687,-0.05664383,0.021127218,0.031717267,-0.07429272,0.043092627,0.09788984,-0.010164805,0.03673418,0.036752153,0.0059633185,-0.014921249,0.013604366,0.03175969,0.009160736,0.052480675,0.015560526,-0.076735675,0.0011284143,0.095090486,0.009907033,-0.025093043,-0.0636849,-0.13994354,0.029739358,-0.034971844,-0.028604964,0.012098477,0.024627127,-0.015865598,-0.08924958,-0.034372766,0.07282197,-0.042682514,0.07096797,-0.00043174007,-0.025636714,0.062333614,0.04773346,-0.0670412,-0.036182687,-0.0440863,-0.051693816,0.05644254,0.07157212,0.0032100982,0.085976616,-0.028732449,0.062938854,-0.034139723,0.04057353,-0.006140648,-0.046089318,0.060313575,0.059108127,0.021549128,-0.036111582,0.08413162,-0.018682187,0.04835481,-0.018007841,-0.08724988,-0.06724739,-0.04276063,0.010491375,-0.014486291,-0.07039975,0.08332621,0.07114926,-0.013557184,-0.0038193269,0.019425213,0.0007197936,0.03381208,0.05702439,0.0936859,-0.029415103,-0.03925976,0.014702105,0.02230145,7.1688665e-35,0.11274642,-0.1302459,0.08319462,0.017187038,-0.023930872,0.010187366,0.054498017,-0.100972444,0.012659018,-0.009829667,0.14155298,-0.008523395,-0.03475622,-0.06340757,-0.009624369,0.00085249374,0.057119418,-0.016782673,-0.012352406,-0.03447509,-0.034527954,0.052793942,0.0016357908,0.089306705,-0.022783248,0.005539562,0.10192433,-0.02571019,0.044853337,0.03273411,-0.038430355,0.011585374,-0.0056039286,-0.009619377,-0.033462606,0.086880855,0.026891757,0.00058213586,0.009021519,-0.02205697,0.019605668,-0.017368603,-0.017095683,0.08054899,-0.008594225,0.04360087,-0.068127744,-0.025982719,-0.07803162,-0.051072422,0.14151756,0.033296194,0.048768297,0.0448023,0.056105502,0.011089741,-0.018673597,0.01844119,-0.018172631,0.041797712,0.0031589675,-0.0684246,0.0015402614,-0.015573406,0.09180378,0.012237789,-0.07079706,0.10706396,0.01980984,-0.013825766,0.039064445,-0.009318451,0.0226998,0.037614323,0.011299798,-0.060841054,-0.017744865,0.04718657,0.055237345,-0.078563444,-0.004390561,-0.016206313,-1.556429e-05,-0.02561496,0.019172454,-0.08257416,-0.013458116,0.13261773,0.02429992,0.092005044,-0.034830417,0.013531624,-0.09139921,-0.030141227,0.06884449,-2.2845809e-08,-0.055989686,-0.016635505,-0.037858896,-0.007167476,0.041280396,0.08108199,-0.02491827,0.06363879,0.042716492,0.03315486,-0.048551098,0.054203976,0.024699744,0.05421774,0.040315285,0.018531123,-0.10114951,0.042119615,0.027244054,-0.022972114,-0.12345625,0.09507219,-0.17644295,0.005192524,0.013935459,-0.04627376,0.014735937,0.03618292,-0.03026974,-0.0069969087,0.020623611,-0.051180787,-0.0025966116,-0.011567547,-0.107156605,0.107445106,0.031492822,-0.071538605,-0.055031583,0.055076893,-0.066484354,0.01190599,-0.030853318,-0.013103204,-0.066983655,-0.05247319,0.01783029,0.049501315,-0.059354007,-0.025254125,0.05970844,0.033885922,0.013661145,-0.040266976,-0.034391865,-0.006367314,0.022173535,-0.10985242,-0.03420797,0.02980708,0.053326298,0.012060363,0.112306654,-0.010795159 +1.3.8.2,"The enzyme catalyses four successive dehydrogenations, resulting in production of 4,4'-diapolycopene. While the enzyme from Staphylococcus aureus was only shown to produce 4,4'-diaponeurosporene in vivo [4], it is able to catalyse the last reaction in vitro [5].",384,1.0,0.038160983,-0.039752744,-0.052113373,-0.06862502,-0.051151436,-0.024935437,-0.06425929,0.038271613,-0.0042636143,0.00296702,-0.04038581,-0.052275844,-0.01683755,0.04659664,-0.050538793,0.061500546,-0.13558483,0.021424487,-0.012514505,-0.0060732276,0.065668985,-0.07429412,-0.034768686,-0.037356786,0.05829027,0.061808284,0.048243575,-0.05507705,0.0138391545,-0.06495307,0.024016961,-0.05594846,-0.013801377,-0.035153907,0.038221113,0.0066472315,-0.038283873,-0.008998266,0.060177296,0.072650865,0.07875834,0.04533955,-0.027653337,0.04065184,-0.02043926,0.021309208,0.004260978,0.036312662,0.044473227,-0.055731427,-0.0100018885,0.003914846,-0.03201607,0.04671333,-0.043112952,-0.030458353,-0.07878943,0.012784263,0.02003697,0.009557858,0.105154335,-0.03541591,0.0039881505,-0.072982304,0.03250948,-0.05277381,-0.017587656,-0.11530697,0.043813948,0.03619299,-0.039723936,-0.012100841,0.03204266,0.028771061,0.039000742,0.016242433,-0.008283805,-0.025586927,0.026409155,-0.017159544,0.08373061,0.021191403,0.02764831,0.06786226,0.054705102,0.08566214,0.013384929,-0.040003452,0.04836228,0.049140546,-0.0043608793,-0.018641597,-0.055462044,-0.043189075,-0.09509407,0.027399013,-0.02788576,0.016010722,0.08063869,0.004053857,-0.014152239,0.015809286,-0.041722383,0.010598626,-0.034037568,-0.024630444,0.03059606,0.029886521,-0.031265385,0.027241843,0.03574399,0.055320583,0.050327014,0.00019252379,-0.054812938,0.114833266,0.00958372,-0.07380022,-0.057547808,-0.07862314,-0.0067167752,-0.0031902306,0.06603449,0.029246658,-0.040377945,0.015191765,-0.054128677,3.6581145e-33,-0.016787434,0.061325468,0.052395515,-0.0379644,0.00551402,-0.007905585,-0.083457194,0.07883525,0.03496877,-0.0812477,-0.09449142,-0.07978756,0.06463153,0.029298896,-0.022581799,-0.030058332,0.09851232,0.044546098,-0.002732852,-0.040250573,0.01193217,0.020359263,-0.026254766,0.063624844,-0.0003499136,0.065369055,0.022820508,0.051362827,0.07651443,-0.030704316,-0.031429842,-0.06440435,-0.0054678502,-0.0024936646,0.048019238,-0.031721234,-0.08324343,-0.022267843,0.07005666,0.050148167,-0.050845437,-0.020528788,0.014899773,-0.02133118,0.016290562,-0.022565832,-0.048886675,0.09797131,0.021055244,-0.02558916,0.043836337,0.026278913,0.05457804,-0.053770795,-0.016186558,0.011967685,-0.04479966,-0.07523229,0.099271566,0.037018556,0.014427651,0.058588192,-0.06461883,0.024907207,0.02800557,0.013761684,0.02587938,0.026597736,-0.0034760854,0.06774779,-0.04145123,-0.027220478,-0.011844117,-0.048911843,0.024750125,0.032878865,0.009515552,-0.01223939,0.03602091,-0.050282724,-0.034059286,0.041962843,0.045413185,-0.05699327,-0.015942246,-0.0001963818,-0.022605242,-0.055204187,0.012321115,0.120836586,-0.040094838,-0.08126158,-0.049169004,-0.022604493,-0.0059788427,-4.0078895e-33,0.06728951,-0.10078217,-0.042028606,-0.073662646,-0.041857827,0.07761618,-0.0077564623,-0.0004207005,-0.0059255124,0.0035347382,0.044419203,0.005956059,0.06292735,-0.020824062,-0.024406534,0.051981755,-0.045199707,0.06238034,0.0002818689,-0.0047044633,0.0052392613,0.13855124,-0.031539496,0.0640239,0.02820594,-0.013008618,0.080949746,0.02743718,0.021802567,0.07495295,0.0068699247,-0.072709,0.0031463346,0.05356261,-0.037205808,0.09481934,0.04483757,-0.027924009,0.04645879,0.00899834,-0.043413773,-0.029193902,0.01928657,0.031721912,0.04954066,0.00047680142,-0.08427645,0.04753025,0.01956261,-0.06570037,0.072764784,0.042146493,-0.024499882,-0.038580894,-0.052806508,0.02098542,0.044030327,-0.05706448,0.02848086,-0.04311401,-0.06931766,-0.1399243,0.08539935,-0.04490151,0.016375493,0.051788695,-0.067940526,0.07196504,-0.013384168,-0.06029996,0.029014815,0.02542879,-0.058916677,0.0494357,-0.07100687,-0.0075358194,-0.010379947,-0.066975206,0.036480118,-0.009096425,-0.079853274,0.021268038,0.022719303,-0.080304794,-0.038842287,-0.10036955,0.06808629,0.10871787,-0.0455476,0.086910665,0.033263538,-0.0050979625,-0.00013196668,0.09328246,0.081492946,-3.8223956e-08,0.0682254,0.015768934,0.06695733,0.007078516,-0.045365524,-0.008311608,-0.03412131,0.007976931,0.039780334,-0.08047776,-0.05207926,0.012235931,-0.018718721,-0.0023937759,0.042931505,-0.012344053,-0.0868702,-0.014655904,-0.04087265,-0.07176556,0.0015137135,0.032696005,-0.113011315,0.009358046,0.025299316,-0.0127875,0.037249174,0.019438855,-0.06638721,-0.010818989,0.059169594,0.025169378,-0.009568942,-0.05536151,-0.060355473,-0.04836126,0.010080389,-0.02604345,0.026599728,0.005258582,0.024676193,-0.0002705334,-0.050777476,0.059374128,-0.10838569,0.058677528,-0.07399844,-0.05223976,-0.020880096,0.09138897,0.10112218,0.013218774,0.029903324,-0.0023714888,-0.11753139,0.017246952,-0.068633065,-0.087725274,-0.10037604,-0.026189877,-0.017369408,0.037629668,0.22324371,-0.006201481 +1.5.1.37,"The enzyme from Burkholderia phenoliruptrix can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. Unlike EC 1.5.1.36, flavin reductase (NADH), the enzyme can not reduce riboflavin. The enzyme does not use NADPH as acceptor.",384,1.0,-0.013424491,-0.03173565,-0.12961619,-0.029055612,0.04947372,0.044244073,-0.12531021,0.07022882,0.02263447,-0.078537606,-0.014139936,0.034913607,-0.10118745,0.042442042,-0.030040028,0.039548445,-0.05033496,0.057449497,-0.014469713,0.03377178,-0.00016758895,0.009744811,0.08076687,0.054910358,-0.01320152,-0.0476019,-0.0037782842,-0.028409742,0.01314885,-0.06513795,0.004576238,0.013537289,0.060859885,-0.059945438,-0.030104265,0.09850959,-0.006271493,-0.029552436,-0.008020059,0.048123825,0.034351833,-0.024483241,0.016565995,-0.057315808,0.011162339,-0.0049620555,-0.05335706,0.10721041,0.056059744,0.03834791,-0.08066255,-0.023334324,-0.018981684,0.004096008,0.025924921,0.019555902,-0.03817136,-0.08815541,-0.0101879025,-0.012925894,0.034310784,-0.029526241,-0.044610627,0.0058480124,0.087269336,-0.01999704,-0.00978684,-0.07674076,0.014319856,-0.017727045,0.037812017,-0.006950754,-0.008695119,0.03334336,0.01648536,0.06605208,-0.030306708,0.009927152,0.050178904,0.04163755,0.06333071,-0.008666382,-0.029414382,0.042087205,0.011196039,0.00996837,-0.044861037,0.015424357,-0.06808443,0.032352176,0.08850166,0.029028384,0.06429631,-0.0536208,-0.13095047,0.037996855,0.02618218,0.026986303,-0.030698441,0.01004101,-0.022278111,0.042680245,0.015421049,-0.05523122,-0.103697225,-0.035033308,0.014989152,0.029984565,-0.0027777874,-0.055299707,0.015361199,-0.012292731,0.014321553,-0.04760826,-0.06006439,0.086600766,0.0002548294,-0.097101904,-0.077057585,0.014890726,-0.034391675,0.0033767975,0.052527096,0.07055419,0.067932054,2.4455612e-05,-0.11930709,5.6988146e-33,0.091870286,0.01242255,0.0028901026,-0.081540965,0.039331123,0.053500976,-0.08469854,0.0065943347,0.037793964,-0.075020626,-0.045313276,-0.007846561,0.037025794,-0.08604828,0.024836015,-0.075372316,-0.0049504563,-0.037195094,-0.0015704724,-0.012113893,0.10722526,0.02862083,-0.040859606,0.066419855,0.038363434,0.0093920175,-0.030853536,0.028917693,-0.0005263445,0.017370485,0.038382955,-0.080011964,-0.08505654,0.01893073,-0.03742653,-0.02533136,-0.11577078,-0.091517374,-0.056639336,0.024795933,-0.03281964,0.021996543,-0.050950475,0.05815337,0.07121827,-0.09980523,-0.0062766597,0.04800918,-0.004746454,0.10192488,0.059557956,0.003573224,0.034238078,-0.005408431,0.012999936,-0.009094656,0.002947118,-0.0042442735,0.0020387338,0.050463807,0.022602996,0.02694315,-0.0117477225,0.054903343,-0.064575605,-0.015665391,0.00942074,-0.0820705,0.014669366,0.010143854,0.07314166,-0.01807647,0.03659644,0.052772984,0.0029861354,-0.059018295,0.04741239,-0.011508684,-0.030439826,-0.04563182,-0.03734769,0.02597592,-0.0012128622,0.020562775,-0.03643467,0.058209736,0.0064073433,-0.06866174,0.057329264,-0.059444524,0.05242563,-0.09131964,-0.002977082,-0.055392105,0.044477414,-3.632086e-33,0.045336604,-0.12124484,0.045235608,-0.029385047,-0.055229113,0.05178839,0.044079334,-0.050875977,0.048595224,-0.05500451,0.07522945,-0.0034430884,0.01343342,-0.017264383,0.040585473,0.06777823,0.0025910572,-0.020451663,-0.021469824,0.0058056153,-0.0784021,0.10089253,0.05737033,0.046855185,0.034287315,0.027155468,-0.01371327,0.02724577,0.07831629,0.04167286,-0.035086688,0.01810157,-0.108768284,0.0008814022,0.018878212,0.012797142,-0.05334778,0.061642595,-0.019909773,0.051969845,-0.016397452,0.03275624,-0.05774547,-0.008889475,0.011175633,0.042387165,-0.05320869,-0.0526431,0.10043028,-0.049361836,0.03443257,0.0421526,0.018998051,0.06799473,0.033303633,-0.001974559,0.09718348,0.008283057,-0.024914496,0.00043533195,-0.007051974,-0.11380272,0.0134460535,0.0011306449,0.08245915,0.031291187,0.017846148,0.119074315,0.0401873,-0.055598594,0.033447612,-0.01854975,0.115255155,0.13743174,0.003651773,0.037998144,-0.04595971,-0.0047905114,-0.027771557,-0.011561695,0.006730801,0.022612125,-0.02636115,-0.048687305,-0.008507146,-0.020695098,0.010633098,0.007856109,-0.042856134,0.055138648,0.024977878,0.031491388,0.0719351,0.018504318,0.08426885,-3.3280173e-08,0.062361278,-0.048646532,0.0048804344,-0.039544404,0.042602826,-0.07204378,-0.065877646,-0.06717502,-0.051023986,-0.029090658,-0.096860886,0.09627962,0.008653079,-0.0003918812,0.07267475,-0.013584933,0.01521643,0.016908742,-0.055267278,0.0013268046,-0.06256608,0.04375087,-0.10036194,0.028535455,-0.050439805,0.029920131,0.028621819,-0.0007841521,0.08437352,-0.04135428,0.071741425,0.058554072,0.076909415,0.003180784,-0.11308354,0.01317543,0.03212999,0.032385774,-0.135589,0.09108968,-0.029820893,-0.102267265,-0.022462562,0.0043213456,-0.050227445,-0.067722276,0.043281056,-0.033778023,0.039769504,0.0142599875,0.036504824,-0.0008838424,0.046703707,-0.041396324,-0.058120627,-0.01928676,-0.0074818064,-0.024968198,-0.02355476,-0.042696666,0.025055882,-0.01363661,0.15523215,0.028611366 +1.5.1.38,"The enzymes from bioluminescent bacteria contain FMN [4], while the enzyme from Escherichia coli does not [8]. The enzyme often forms a two-component system with monooxygenases such as luciferase. Unlike EC 1.5.1.39, this enzyme does not use NADH as acceptor [1,2]. While FMN is the preferred substrate, the enzyme can also use FAD and riboflavin with lower activity [3,6,8]. ",384,1.0,-0.006614027,-0.11674463,-0.0982272,-0.020274239,0.066484235,0.0008794558,-0.08265303,0.103211515,0.051473804,-0.046988938,-0.019868165,-0.03809655,-0.08272262,0.14090003,-0.020746883,-0.03708673,-0.05190149,-0.017392011,0.017185183,-0.011145265,0.01474307,0.009366819,-0.0067480677,-0.04301352,-0.04510115,-0.05653395,0.009028185,-0.015173853,-0.017325744,-0.05847317,0.04948076,0.007346307,0.020908881,-0.030996958,0.008037474,0.016784757,0.034683935,-0.054714352,0.037746612,0.005416971,-0.038101654,-0.0019311125,0.006612961,-0.08015635,-0.006146855,-0.06291979,0.026662324,-0.02367798,0.0794455,-0.03193352,-0.061642893,-0.033772495,-0.008090865,0.09505672,0.06406074,0.020938823,-0.030373808,-0.09296622,-0.049523056,0.022517651,-0.003438702,0.038659535,0.0088113295,0.00010506674,0.07223456,-0.038016494,-0.03131653,-0.10320354,-0.057175245,-0.024499062,-0.0578161,-0.0279981,0.010770741,-0.0278398,-0.033875536,0.06458545,-0.018875694,0.0040738075,0.007995502,0.031168398,0.020847341,-0.0064858077,-0.0030742013,0.042199086,0.0018402666,-0.019868523,-0.00068177446,0.057141293,-0.021949224,0.092176415,0.02817619,0.037629712,0.008779894,-0.09817396,-0.028591892,0.010193871,0.011671546,0.055409078,0.04434332,-0.018228004,-0.0657787,0.033667263,-0.015873764,-0.02413431,-0.05637681,0.0070996494,0.03974265,0.14423756,0.036119483,-0.01077253,0.007638235,0.04502245,0.013244703,-0.043894224,-0.04361077,0.045639545,0.01172323,-0.081975654,-0.059611455,0.057389405,-0.021369344,-0.0065538744,0.10640232,0.13407904,0.0510497,0.006783792,-0.13299957,2.654766e-33,0.024307644,0.006378432,-0.013815352,-0.11534812,0.016191624,-0.02217487,-0.04321471,-0.0009687816,-0.014216777,-0.079097025,-0.094016805,0.02241305,0.04139691,-0.01571431,-0.0055319523,-0.03479762,-0.011126619,-0.058751352,-0.00851058,-0.005942114,0.094613194,-0.0010245352,0.044797864,0.06814462,0.05362653,-0.007898859,-0.043803748,0.08709589,-0.01077581,0.0036056517,-0.008616157,-0.090146765,-0.019294787,0.03476472,0.086780235,0.03687946,-0.045522258,0.032932516,-0.034455955,0.013746792,0.049534477,0.053564534,-0.0050043454,-0.010343723,0.082636,-0.046832785,-0.07429176,0.12763497,0.048847347,0.09506565,0.03560409,-0.018022528,0.024666905,-0.092972286,0.048880816,0.019803952,0.018321712,0.020778324,0.029847713,0.0039988006,-0.020757796,0.02537936,-0.059942476,0.019160291,0.00389282,0.062775575,0.009826355,-0.025489546,0.02163678,0.08024047,-0.051538628,0.044090573,0.065363824,0.084518984,0.041003898,-0.07316703,-0.018574929,-0.034614347,0.06073223,0.005465259,0.016879894,-0.023701578,-0.04980881,-0.028839845,-0.050623767,0.051748373,0.0024003393,0.0154188275,-0.023605177,0.020020342,0.07536205,-0.08376658,-0.018382644,0.01863335,-0.0058317045,-3.172908e-33,0.036540817,-0.073633164,0.039897818,-0.063654415,-0.05611074,0.13983989,0.025179405,-0.05124477,0.027366599,0.0005546993,0.04918949,0.040495142,-0.010798259,-0.05074797,-0.022584714,-0.022197008,-0.02432702,0.019421425,0.031877253,0.022641785,-0.062062364,0.08022095,-0.015017086,-5.461531e-05,0.028115572,0.02488515,-0.05189457,0.11876322,0.01021235,0.013846623,-0.055275988,0.04936252,-0.045668535,-0.09007758,0.025247648,0.039086804,-0.040069718,-0.03624591,0.0031657624,-0.015072164,-0.009956414,0.04740342,-0.011580795,0.049001653,-0.05830453,0.12669648,-0.084655665,-0.023997562,0.05104102,-0.062182184,-0.029285656,-0.014541597,-0.027948482,-0.0013814102,0.007888727,0.026143363,0.05280957,0.06196807,0.01952769,-0.012718237,0.04348725,-0.09539582,0.058042318,-0.04349494,0.012531983,0.016539967,0.025733516,0.099573985,-0.009831951,0.017015694,0.04985894,-0.040835313,0.07604222,0.045289025,0.0029117863,0.013159201,-0.039466728,0.00018162058,0.00048287888,0.018514378,0.040914886,0.085568644,-0.093649395,-0.07535014,0.024045771,0.02506531,0.04616105,0.034630116,-0.026694447,-0.01241535,0.043865256,0.06450139,0.00421491,-0.079295516,0.060522005,-4.33549e-08,0.040234383,-0.095077485,0.07771796,-0.07621778,0.04989067,0.0399934,0.014150694,-0.0067496803,-0.003935737,0.017160585,-0.019248484,0.11200422,-0.054405343,-0.037127744,0.03064506,-0.025543438,-0.056204498,0.009285878,-0.019615257,0.00949076,-0.0865441,0.04058049,-0.090507485,-0.039560176,-0.010780248,-0.045176335,0.0052207345,-0.009874265,-0.0067993584,-0.020906648,-0.017335875,0.045315843,0.042906977,0.0015229179,-0.18008292,-0.03573753,0.0045033796,0.014904784,-0.13066494,0.019444903,0.05879051,-0.078177944,-0.059084807,-0.04186471,-0.03499228,0.025844323,0.024221044,0.043018054,-0.022997059,0.0043045124,0.06640469,-0.038263254,-0.023566099,-0.039807662,-0.11804843,-0.018909965,-0.002637146,-0.09195495,-0.037420563,-0.03225876,0.029211013,-0.017684942,0.17459702,-0.0005690552 +1.5.1.39,"Contains FMN. The enzyme can utilize NADH and NADPH with similar reaction rates. Different from EC 1.5.1.42, FMN reductase (NADH) and EC 1.5.1.38, FMN reductase (NADPH). The luminescent bacterium Vibrio harveyi possesses all three enzymes [1]. Also reduces riboflavin and FAD, but more slowly. 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+1.5.1.40,The enzyme has an absolute requirement for both the 5-deazaflavin structure and the presence of an 8-hydroxy group in the substrate [1]. 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+1.5.1.41,"Catalyses the reduction of soluble flavins by reduced pyridine nucleotides. Highest activity with riboflavin. When NADH is used as acceptor, the enzyme can also utilize FMN and FAD as substrates, with lower activity than riboflavin. When NADPH is used as acceptor, the enzyme has a very low activity with FMN and no activity with FAD [1].",384,1.0,-0.014754259,-0.059909936,-0.10055394,0.0030800814,0.082570545,0.03967254,-0.027043596,0.0676975,0.04416021,-0.0018762709,-0.021028366,0.107149005,-0.1327317,0.119510695,-0.012420306,0.013385405,-0.07483401,0.03029677,0.008616308,-0.0081325695,-0.025117436,-0.027082235,0.058759026,-0.013670232,-0.027190875,-0.017206283,0.009483726,-0.042940773,0.043529138,-0.039507303,0.055674184,0.029474104,0.07711689,-0.03220231,-0.054632578,0.07517368,0.005906684,-0.024723941,-0.01972122,-0.011050476,-0.016852858,-0.04207577,0.04167602,-0.056684487,-0.0070165037,-0.019807903,0.014590435,0.10128821,-0.008911121,0.04918978,-0.034098778,0.032419384,-0.07029704,0.0024977517,0.028443426,0.013371622,-0.035223573,-0.090796754,-0.028151136,-0.032647967,-0.005973111,0.009511542,-0.07218447,0.0013528792,0.071410954,-0.059732895,0.051967543,-0.05690665,0.006849356,0.010606208,0.011654889,-0.002656799,-0.03051262,-0.044074055,0.014228871,0.04470099,-0.04949086,-0.027693521,0.042818055,0.033593114,0.05376605,-0.022692846,0.010005419,0.072189435,0.0326536,-0.0053891283,-0.120662995,0.02438713,0.005230857,0.06795728,0.054219175,0.058836494,0.03605936,-0.034397777,-0.09373752,0.062825575,0.054831762,0.038659174,-0.026820485,0.03020284,-0.012278113,0.04100161,-0.054507006,-0.059541695,-0.070290245,0.0174054,0.030694596,0.059279807,-0.035705864,-0.025735857,-0.011454486,0.009960013,0.010877538,-0.03859581,-0.101213805,0.103173524,0.022070086,-0.066866614,-0.08299338,0.02821766,-0.06768768,0.032152295,0.09435956,0.11487895,0.0041183704,-0.003759601,-0.090949155,4.859347e-33,0.044673715,0.017175788,-0.015155154,-0.060406454,0.01076493,0.00743774,-0.06212477,0.03442758,0.011990381,-0.035789303,-0.056366883,-0.02149396,0.078036405,-0.029525172,0.033776358,-0.09195373,0.01472122,-0.040136546,0.0180557,-0.06605566,0.09955183,0.03372453,0.023549493,0.09008485,0.06704834,0.05132888,-0.04115957,0.07190964,-0.010059335,-0.012285399,0.085813835,-0.10282138,-0.06140392,0.04503574,0.018455975,0.009777846,-0.14268275,-0.04075792,-0.035968233,0.068024695,0.0025758133,-0.011593821,-0.067868024,0.020018464,0.057642803,-0.074994214,-0.01891723,0.079655305,-0.00912164,0.07739779,0.11409478,-0.0075633815,-0.009604155,-0.031099398,-0.015216933,0.018451698,-0.00109777,-0.043036513,-0.0022498488,0.055556003,0.030417792,-0.031693276,-0.014266228,0.0282005,-0.06445534,-0.029161362,0.02276248,-0.10498681,0.023623323,0.05003223,0.0141827855,0.0015463042,0.07463292,0.020491334,0.07248964,-0.009087972,0.020413006,-0.019992819,0.024549643,-0.021498645,-0.027318688,0.01763402,-0.003966424,0.015666636,-0.06538046,0.014091889,-0.029473413,-0.089082316,0.022199027,-0.012091492,-0.0038299316,-0.10726344,-0.030501528,-0.050863784,0.09252731,-4.6267987e-33,0.02450136,-0.07503186,0.023017071,-0.044212505,-0.08820025,0.061314557,0.0399084,-0.12137703,0.060119946,-0.05567437,0.010251446,-0.0046465867,0.010985765,-0.0093397945,0.03231542,0.029033743,0.0039130254,0.008521699,-0.0022069416,0.038166523,-0.06578703,0.09831525,0.03899558,0.033087276,0.027157076,-0.004092319,-0.021253338,-0.020834083,0.08670782,0.09714586,-0.052704632,0.020856496,-0.037495676,-0.03858359,0.010398974,0.046903607,-0.05035481,0.053280063,-0.054000657,0.025888378,0.018924754,0.05776551,-0.033975806,0.02387539,-0.0038775452,0.0715274,-0.09114866,-0.06075396,0.02264607,-0.073241495,0.0708526,0.018637046,-0.0034996024,0.030650718,0.09302916,0.027797429,0.061079185,-0.03590908,0.015026985,-0.015714828,-0.0024020877,-0.09888336,0.008875488,-0.029141372,0.085137054,0.032149773,0.011592014,0.10989471,-0.0018475862,-0.056625303,0.050075684,0.006308348,0.09926356,0.10331738,-0.0032768091,0.026000077,0.0059449766,0.0033400508,-0.023151461,-0.022125188,-0.01354719,0.030885883,-0.03138952,-0.10788181,-0.045491077,-0.038636714,0.026689066,0.013108506,0.016007634,0.060202923,0.027311414,0.042398535,0.077685274,-0.008514783,0.05946166,-3.5876017e-08,-0.009417732,-0.050273493,-0.018700108,-0.05185878,0.012474839,0.061379123,-0.005274955,-0.024312397,-0.020218391,-0.051858988,-0.06276355,0.07317915,0.04112213,-0.022916725,0.104209125,-0.036640715,-0.061532147,-0.011695488,-0.07433772,-0.043064423,-0.07239047,0.101786464,-0.10789309,-0.01360078,-0.023494774,-0.010409963,0.005730035,-0.042067174,0.020013366,-0.018508272,0.026433704,0.034889415,0.05745709,-0.022549827,-0.0910989,0.0024067753,0.089712426,-0.032523468,-0.086274356,0.0765142,-0.061961528,-0.031475727,-0.05426598,-0.020215167,-0.057323605,-0.01842949,0.00013241754,0.024058167,-0.037250154,0.06081776,0.06527662,0.017199881,-0.025266487,-0.053663015,-0.092367366,-0.035642337,-0.033851437,-0.055458445,-0.057216555,-0.09845133,0.010960234,-0.011618362,0.095468946,0.01581346 +1.5.1.42,"The enzyme often forms a two-component system with monooxygenases. Unlike EC 1.5.1.38, FMN reductase (NADPH), and EC 1.5.1.39, FMN reductase [NAD(P)H], this enzyme has a strong preference for NADH over NADPH, although some activity with the latter is observed [1,2]. +While FMN is the preferred substrate, FAD can also be used with much lower activity [1,3]. ",384,1.0,-0.063421816,-0.051661618,-0.08281014,-0.001777787,0.05741383,0.015055115,-0.055066913,0.10503953,0.036569282,-0.029673781,-0.025928648,0.009318236,-0.078145854,0.062145013,-0.006773991,-0.02358357,-0.036573675,-0.06437888,0.024599072,-0.0010106211,-0.0052988552,-0.036026124,0.018798381,-0.03889758,0.0058968905,-0.023549283,-0.005099602,-0.0014931215,-0.048443347,-0.08791837,0.059693865,0.008557683,0.020698192,-0.011357157,-0.07351365,0.089054585,-0.004098127,-0.018726494,-0.053091798,0.011718927,-0.024524445,-0.007898432,-0.008174129,-0.08384294,-0.025864791,-0.038073365,0.00043683668,0.023923574,0.049452204,0.032082427,0.0040589115,-0.034788318,-0.013279891,0.06587804,0.092718534,0.041697793,-0.03896084,-0.02764406,-0.09632852,0.0034574314,-0.034563426,0.006718662,-0.04202646,-0.006484675,0.094450876,-0.015300135,-0.012606846,-0.10488019,-0.040673837,-0.03155275,-0.06582746,-0.04457125,0.008414255,-0.09891886,-0.019503674,0.015645517,-0.05149736,-0.04321773,0.056645993,0.031160874,0.024573263,0.06617382,0.018136919,0.05061972,0.06099422,-0.0095332,-0.0153134335,-0.011373234,-0.044226866,0.035074092,0.03249581,0.03997802,0.025297927,0.014905867,-0.057314634,0.077155255,0.036281746,0.099473536,0.012538148,-0.017443439,0.014464666,0.07951465,-0.008122755,-0.018694391,-0.07751267,-0.03427043,-0.025950775,0.12912743,0.026110815,-0.044238977,0.011827146,-0.0104594985,0.013423754,-0.03259954,-0.06726143,0.070648275,-0.03412178,-0.084174186,-0.063254565,0.025057696,-0.031692304,0.008528831,0.053304374,0.09374137,0.07613444,-0.003325481,-0.12911195,1.3122123e-33,0.053261746,0.014681019,-0.03977093,-0.055509605,0.0052507063,0.04685714,-0.06393393,0.055769213,0.0030651668,-0.043208074,-0.013653736,0.017043145,0.02261658,-0.007274326,-0.016317226,-0.0638146,-0.008747474,-0.040182527,0.012585408,-0.031046266,0.09217142,0.021913305,0.0014985761,0.030876668,0.029977724,-0.013827486,-0.06073112,0.073111095,-0.038691234,0.019248465,-0.0037680077,-0.10480252,-0.064043686,0.039528403,0.007235759,-0.01376438,-0.100383,0.013436766,-0.07646088,0.034840204,0.0001156043,0.03883961,-0.0017120565,-0.06697537,0.10134367,-0.10667907,-0.08695494,0.13328229,0.03931731,0.10921715,0.04434071,-0.025490763,0.106192224,-0.03282707,0.0036097,0.055168957,-0.03960203,0.017891772,0.021008197,0.064198256,-6.94017e-05,0.028430674,-0.0454156,0.08370721,-0.023860319,0.07728931,-0.03153946,-0.065819785,-0.004971451,0.12773363,0.022241278,0.05288929,0.06742225,0.034426756,0.033167083,-0.03616056,0.046157982,-0.008725581,0.023545254,0.021045815,0.00095810654,0.008151428,-0.0756345,-0.035754107,-0.051606078,0.010094916,0.0027676965,-0.07486178,-0.0011633504,0.05736239,0.077914864,-0.08402985,-0.053822182,-0.06717673,0.05089956,-2.0513941e-33,0.04519238,-0.060292568,0.0201328,-0.11127059,-0.005129667,0.12550825,0.083235666,-0.056194488,0.01980656,-0.0021704584,0.0565931,0.03175512,-0.020244217,-0.022938238,0.0263601,-0.008565304,-0.032031987,0.0063951146,0.07911146,0.05274282,-0.05052106,0.12711534,0.006350161,0.040747717,0.06425239,-0.040539004,-0.08378587,0.068103656,0.061102785,0.02735367,-0.08046347,0.03278573,-0.043161664,-0.007308734,0.027290184,0.057638027,-0.09406479,0.0063642724,0.003308137,0.04242842,-0.0012104121,0.018383417,0.0016630936,0.047592048,0.05064254,0.068299,-0.17728834,-0.0014671534,0.05716752,-0.08208036,-0.025972659,0.009138475,-0.015133424,0.005095769,0.018596787,0.017120674,0.010775617,0.057204735,0.057407003,-0.016168782,0.025142094,-0.09456953,0.0037854968,0.0033377586,0.015800016,-0.025759926,-0.01739848,0.017211897,0.004277662,0.0690932,0.0631847,-0.017267182,0.08027682,0.061085027,-0.018960867,-0.04741797,-0.037054602,0.06891695,-0.019957924,0.016058771,0.0322722,0.057597175,-0.058098678,-0.07408222,-0.03411175,-0.017932214,0.03676139,0.029158905,-0.025679462,-0.015534569,-0.0003575226,0.05471543,-0.04776248,-0.0060814037,0.038505938,-4.3217725e-08,0.048589427,-0.10867457,0.081039384,-0.052230492,0.04917415,0.03811564,0.017519055,-0.024089614,-0.034530167,-0.0023673046,0.006231588,0.1249935,0.028158229,-0.036642276,0.032996133,-0.031166166,-0.025461895,0.025851868,-0.037013438,-0.017324017,-0.05501749,0.048777413,-0.09613587,0.01715064,-0.031867582,-0.038764726,0.019828452,-0.02614565,0.0019991803,-0.043688513,2.3522365e-05,0.04287118,0.06425037,0.0018549269,-0.1273238,-0.0069647995,0.001133492,0.031241776,-0.12506722,0.042092685,0.01434635,-0.09101742,-0.040740438,-0.012416624,-4.3545653e-05,0.022383213,0.060282353,-0.02716336,-0.0147165805,-0.0024863163,0.031512152,-0.026050279,-0.020420818,-0.050649915,-0.056093775,0.028243981,-0.0044602146,-0.07379967,-0.038072094,-0.0504836,0.036830477,0.070404805,0.12258498,-0.0011027295 +1.7.6.1,Contains ferriheme b. The enzyme is one of the nitrophorins from the salivary gland of the blood-feeding insect Rhodnius prolixus. Nitric oxide produced induces vasodilation after injection. Nitrophorins 2 and 4 can also catalyse this reaction.,384,0.99999994,-0.008885858,0.002599489,-0.11464922,0.009478418,0.08412077,0.06862117,0.004839871,-0.0070960023,-0.005800435,-0.03545509,-0.0038200698,-0.11696972,-0.091157936,0.02058461,-0.047289204,0.030397004,0.037068263,-0.018952467,0.02571955,-0.05222499,0.039651047,0.044199802,-0.0017197495,-0.09267236,-0.013126444,0.05810091,0.009088639,-0.057541016,0.02693574,-0.09980286,-0.0017998951,-0.02924679,0.019774752,-0.07989477,0.042878397,0.017563602,-0.05520937,-0.011390891,-0.004565924,0.04011668,0.018169839,-0.051969524,-0.034489166,-0.029286735,-0.04231879,0.0137141505,-0.002037046,0.07840461,0.0682621,-0.022550587,-0.07708953,-0.08659559,0.0062895077,0.06642875,0.033314273,-0.03160282,-0.020167861,-0.07160754,-0.03704494,0.0019155411,0.060320016,0.02523001,0.030616542,-0.0026513024,0.035037935,-0.042619262,0.018244907,-0.06569059,-0.043464985,-0.10296524,-0.012192763,-0.04132671,-0.0040195496,-0.039364982,-0.027035262,0.06337012,0.033846293,-0.06479036,0.07158655,-0.01735159,-0.004073881,0.060057502,0.055100698,0.08256401,0.028258529,0.059762828,-0.008187931,0.01493708,-0.04033409,0.024279386,0.0032030628,-0.022163192,-0.020761417,0.0067730956,-0.035803057,0.04375927,-0.07826254,-0.0043336325,0.0723285,0.031943876,-0.07417245,0.0097165685,-0.06339178,-0.027333125,-0.1205222,0.042864546,-0.0019605665,0.071535684,0.059398577,0.049626578,-0.013207138,0.0052974676,-0.0053686835,0.030111691,-0.0052832053,-0.0008307974,-0.013831336,-0.04582807,-0.10066463,0.060344264,0.09808893,-0.031598885,-0.0542614,-0.008511257,-0.015935367,0.026925398,-0.089437455,4.6662615e-33,0.076510295,0.03699447,-0.009129824,-0.024455437,-0.0022636803,0.04016366,-0.079234876,0.050328013,0.033131838,-0.018833313,-0.03933782,-0.07610297,0.008956856,-0.0087358,-0.025904108,-0.0005334958,-0.0029860514,-0.013469146,0.09903517,0.00065828033,0.06226811,0.0699106,-0.09716422,-0.03629298,-0.026120856,0.08561885,-0.09796247,0.012110084,0.047739234,-0.008880171,0.06855723,-0.094480164,-0.018713402,0.004108866,0.063234664,-0.041872866,-0.009185237,-0.03849085,-0.12355561,-0.011681514,-0.009062837,0.06376701,-0.0835175,-0.037970595,0.06614096,-0.12297305,-0.17999819,0.06411247,0.13769151,0.01962484,0.06534235,0.004024243,0.10388476,-0.01661607,-0.041562695,0.029900938,-0.026173782,0.0046163364,-0.0018397726,-0.0029163659,-0.037012883,0.012968023,0.044117674,-0.051295944,0.060595233,0.0029592807,-0.016450997,-0.060511217,0.0066475323,-0.021701513,-0.10595977,0.055392575,0.03388091,-0.022930201,-0.033401787,-0.08469558,0.010152969,0.009771844,0.027581152,-0.025176562,0.035979535,0.0037368964,0.09196839,-0.02233689,0.0069032162,-0.005143489,-0.07483984,-0.057542045,0.05547322,-0.030767355,0.035362545,-0.048377316,-0.08943501,-0.036079865,0.031768084,-5.3633087e-33,0.035597105,-0.060950704,-0.015876507,-0.07747553,-0.0008308566,0.110833675,0.0045385994,-0.031831328,-0.05473371,0.036860343,0.01650422,0.02458303,0.07214273,-0.026523745,0.0022662024,0.002062418,0.056184072,0.05948895,0.046809193,-0.040906824,-0.0588022,0.12641007,0.07878696,-0.07025816,0.09359258,0.033883538,-0.0031744211,0.02583503,0.018824387,0.060133148,0.05836908,0.02087241,-0.07150152,-0.09066282,0.040990025,-0.015090565,-0.02326434,-0.033260904,0.044784416,0.026357558,-0.011552939,0.0018087542,0.08111779,0.050956354,0.015648521,0.058108736,-0.07589576,0.00040156388,0.01813972,-0.017687077,0.02487567,0.035899755,-0.10033393,0.070295036,0.04384754,0.038559273,0.0625779,0.035548758,0.06465053,-0.031094221,-0.06303739,-0.019091656,0.038602464,0.026354184,0.04245924,0.04818438,-0.02929437,0.12384501,0.11763298,-0.0072890967,0.051417146,0.069547966,0.052856367,0.032008536,-0.0520315,-0.0039513726,0.0138965715,-0.042564377,0.00807568,0.0042576594,-0.025841989,0.032310937,-0.03676627,-0.0037972992,-0.0016158841,-0.06422027,0.01329564,0.0687442,0.016970588,-0.047723718,-0.03607829,0.014770878,-0.008172608,0.00027030866,0.024664368,-3.7207457e-08,0.021043375,-0.103093006,0.020517295,-0.019472005,0.019728124,-0.03752204,-0.037460815,-0.065887764,0.012035494,0.017051004,0.056247305,0.072861284,0.056599364,-0.07262581,0.09230216,-0.015020768,0.027411666,-0.007582647,-0.04404716,-0.027177706,-0.0525815,0.044370536,-0.07833428,0.004526639,0.0152002415,-0.090084106,0.015313297,-0.07456001,0.0076383986,0.012130698,-0.017600967,0.08083536,-0.022789013,-0.09218026,-0.035717484,0.018479973,0.0072612567,-0.0051997015,-0.02576432,-0.039710276,0.024559475,-0.021343725,-0.002010177,-0.02182574,-0.016005225,0.022592226,0.0085983835,-0.018563924,-0.036345948,-0.02000791,-0.07204213,0.00823281,-0.021033682,0.0049970024,-0.12657206,0.0057382216,0.03694354,-0.039303143,0.054094277,-0.048923854,0.0052145007,0.051481985,0.16052127,0.023821896 +2.1.1.211,The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA). ,384,0.99999994,-0.015188347,-0.081388086,-0.12753369,-0.056505032,-0.046627298,-0.014284817,-0.05546502,0.05298948,0.031265248,-0.012240237,0.04418704,-0.03123032,-0.06459496,0.0070733833,-0.039995983,0.051410194,-0.089061774,-0.04839885,0.036289703,-0.023378856,-0.027569294,0.0837627,-0.011633954,-0.025727343,-0.041095156,0.02449341,0.028675895,-0.053180084,0.053950872,-0.08954396,-0.026496371,8.338328e-05,-0.025299445,-0.00249506,-0.02140016,0.03478583,-0.16051883,0.0012120524,0.05959367,0.009263515,0.034061268,-0.0072985864,0.04283329,-0.02173407,-0.06540966,-0.013109968,0.07985577,0.043982398,-0.07412165,0.041827552,-0.009227743,-0.0125587275,0.035114367,-0.0016617115,0.01559092,0.040381435,-0.048211314,0.012928963,-0.0063340412,-0.03304817,0.06291162,0.009034756,0.054393172,-0.06631729,0.018023849,-0.026070196,0.07224428,-0.015571722,0.024462447,-0.009303026,-0.049921185,0.029654391,-0.03625144,0.013463579,-0.00019555213,0.061564658,0.04189512,-0.06261202,0.02891885,-0.0019142319,0.013081677,-0.040425166,0.06701911,0.007609903,0.070475645,-0.042250596,0.020882646,0.007965375,0.028782414,0.035168476,0.05321859,0.14670429,0.024165248,-0.016493157,-0.072357446,0.04783194,0.07481148,0.05495736,-0.04546442,-0.060398515,-0.01425394,0.057171058,-0.023161506,-0.0021650637,-0.019255903,-0.053802162,0.074297085,0.08108209,-0.040281866,0.040674668,0.05168082,0.097262904,0.022577984,0.02729658,-0.010955193,0.008294187,0.010666515,0.017408267,0.05006216,-0.092222415,-0.080727175,0.004078832,0.008236247,-0.108169235,-0.021225013,-0.019829024,-0.026831495,-3.455752e-33,0.02182663,0.021880329,-0.038015347,-0.03193195,0.05649192,-0.06499504,-0.06729589,-0.039265778,-0.009765769,-0.03234076,-0.09284626,-0.09474067,0.005349728,-0.041268583,-0.007499082,0.012941003,-0.059048466,-0.011564854,-0.018864568,-0.09690334,0.01238615,0.102373526,-0.016454749,-0.016114952,0.035730448,-0.024472937,0.044393532,0.03010996,-0.04917727,-0.0477823,0.06716126,0.048325796,-0.06839162,-0.07361569,0.15034887,-0.03457169,-0.086260065,0.0659654,-0.07417935,0.015724579,0.012932037,0.014885224,0.022919217,0.03186813,0.006624307,-0.04336796,-0.05404945,0.04422986,-0.054925352,0.047403876,0.0006966554,-0.018817663,-0.02737531,0.06849994,-0.006327391,-0.04496149,-0.008908607,-0.09186249,0.002171496,0.05663646,0.0013161136,-0.006836679,0.0058396943,0.04630957,-0.011306901,-0.030888677,-0.057468105,-0.061708387,0.0095628,0.06013075,0.036878075,-0.08609509,0.1366645,-0.07677128,-0.00791519,-0.019822212,-0.10511599,-0.04435686,0.01334025,0.005723245,0.05456437,-0.05288285,0.05005396,-0.026326094,-0.061475527,-0.0022658627,-0.027164675,-0.01539454,0.047313187,0.059698645,0.03574486,0.008192497,-0.037037425,-0.057800196,0.059491638,1.3529214e-33,0.076273926,-0.039204482,0.094086796,0.020276817,-0.05225337,0.036906786,0.018427227,-0.07184609,-0.047754142,-0.11490312,0.15989468,0.149404,-0.06776237,-0.0037441927,0.0836194,-0.049864035,0.032435905,0.035570912,-0.04136382,-0.013342656,0.027870907,0.009201218,-0.07367065,0.08108027,0.008210888,-0.0062196194,0.0048135724,-0.008692024,0.07775374,0.06584909,0.009957918,0.04861344,0.005015848,0.011227175,0.017536722,-0.0034487236,-0.027879238,-0.043257855,-0.012615891,0.02108419,0.033151302,-0.034072038,-0.016884513,0.073963635,0.00039605252,0.05320423,-0.0333258,-0.03624606,-0.1233018,-0.0014556817,0.088925324,-0.034602866,0.0635447,-0.03555528,0.091295935,0.041333664,-0.044730704,-0.035970856,-0.017339727,0.037022594,-0.012751745,-0.023353703,-0.013196432,-0.05614524,-0.023569152,-0.05266546,-0.00571285,0.04218109,0.097260125,0.0031221805,-0.019922681,-0.009285297,0.024010278,0.06425945,-0.038824815,-0.064667016,-0.023436291,-0.018136963,0.03630914,-0.039881885,-0.03437589,0.032801617,0.06791581,-0.06611088,0.030958354,-0.026661307,0.0024952185,0.05985233,0.026636628,0.037702587,0.026667781,0.007458506,0.01846226,0.050446235,0.021382218,-2.5292684e-08,-0.028754765,-0.05362315,0.010019008,0.024742397,-0.035799317,0.07508884,-0.0073001552,0.048128057,0.0744213,0.06974306,0.010533896,0.009313063,-0.019571593,0.065847695,0.023084158,0.037696093,-0.09331659,-0.027258655,0.006254735,-0.027393667,-0.14599535,-0.000351405,-0.08033827,0.008973206,0.043007184,0.021617426,-0.009415849,0.103607774,-0.048185408,0.0072492324,0.12653151,-0.012843708,0.09943815,0.05616071,0.0068667373,0.046323,0.055984247,-0.064521715,-0.019045588,-0.0068781767,0.014698069,0.045269005,-0.07812923,0.016431617,-0.06604873,0.020308936,-0.043102697,0.09515566,-0.099536344,0.020170068,0.018029993,0.028887095,0.006474679,-0.004885265,-0.04356124,-0.014227559,-0.037071362,-0.008003016,-0.014054624,0.012802521,0.112480305,-0.0147944195,-0.0038665305,-0.08298749 +2.1.1.212,"Specifically methylates 2,4',7-trihydroxyisoflavanone on the 4'-position. No activity with isoflavones [2]. The enzyme is involved in formononetin biosynthesis in legumes [1]. The protein from pea (Pisum sativum) also methylates (+)-6a-hydroxymaackiain at the 3-position (cf. EC 2.1.1.270, (+)-6a-hydroxymaackiain 3-O-methyltransferase) [4].",384,0.99999994,-2.2884025e-05,-0.061719667,-0.117669396,-0.06857427,-0.027936004,0.10684706,-0.1207997,0.006590739,0.008171177,-0.022405464,0.0646352,-0.009664505,-0.038889106,-0.09371688,-0.032138273,-0.005099416,-0.06844801,0.03436997,-0.018438147,-0.03665504,0.092954144,-0.013622516,-0.006275069,-0.04384851,-0.022337696,0.023891408,-0.020608546,-0.036912788,0.042684034,-0.07038411,-0.022396326,0.025730891,0.011739174,-0.0052928776,0.045294452,0.07976773,0.024386007,-0.050330665,0.050780926,0.026068369,0.085633256,-0.0846817,0.029545063,-0.08905388,0.03165877,-0.030361863,0.0023678376,-0.03057901,0.04531402,-0.011458552,-0.039411783,-0.05578246,0.028768376,0.10752786,0.04320445,-0.037863404,0.028153902,0.0030543883,-0.03460035,0.047925353,0.019485712,-0.029365122,-0.01303518,-0.027348578,-0.028397134,-0.01858866,-0.051209502,-0.028997561,0.009229537,-0.03363142,0.021270609,-0.022952883,-0.07014978,0.06377046,-0.04079685,0.09154804,-0.03204115,-0.011631136,-0.018711368,-0.070644304,0.016818132,5.007551e-05,0.05628146,0.0795659,-0.024053708,-0.0050043324,-0.06649134,0.027112324,0.053419344,0.06938396,0.057653632,0.0734426,0.05040307,-0.022308886,0.016463336,0.06912044,0.009775464,-0.033828124,0.0055118473,-0.0123333875,0.034182806,-0.004157985,-0.13647918,-0.05836866,0.017899796,0.035227064,-0.05439713,0.006366876,0.026280716,0.020226568,-0.022549607,-0.036725584,-0.019485611,-0.012466723,-0.07035166,0.014852927,0.07846525,-0.049743112,-0.044465616,-0.07601406,-0.040210154,0.009846007,0.08624143,0.072114706,-0.037894197,-0.07233988,-0.13418509,2.7736498e-33,0.088849515,0.017540542,-0.00037229055,-0.03033814,0.020041084,0.0023729426,-0.017149612,0.027201913,0.039804123,-0.07982165,-0.1376606,-0.017355954,-0.022346966,-0.011000679,-0.00058583065,-0.020243369,-0.01666585,-0.024480905,0.02058432,-0.041064136,0.0327288,-0.005844572,-0.029799582,0.0042926203,-0.023069253,0.04049104,0.012707132,-0.0498794,0.008808784,-0.027259354,-0.06977872,-0.079699844,-0.033564474,-0.035682045,0.06363371,0.02095861,-0.051681854,-0.017276289,-0.095645025,0.13232839,0.034536783,-0.050597195,0.018995913,-0.057098527,0.051095247,0.024969118,-0.023595497,0.058843587,0.08699991,0.057483096,0.03612051,0.010699421,0.0713967,-0.005122811,-0.063603304,0.0058184727,-0.0021982417,0.00012195149,0.02941999,0.0562958,-0.04545781,-0.0038954546,0.04406553,0.010481929,-0.08731618,-0.0055024764,-0.105991215,-0.042081982,-0.0022826032,0.050592072,0.013779825,-0.06995893,0.07358645,0.02587232,0.11575651,-0.022373278,-0.06831537,-0.02626411,-0.0009227593,0.03403864,0.059225697,0.006680032,0.020898132,0.003140313,-0.09677388,-0.016868403,0.016643304,-0.046749074,0.01037585,-0.005885623,0.049816757,-0.028017195,-0.04797327,0.05650736,-0.023601962,-3.683187e-33,0.0004869419,-0.078220405,0.027985906,-0.08312435,-0.0028679706,0.024911013,0.011941154,0.0058657434,-0.037369862,0.03340787,0.09478194,-0.034370236,0.025311733,-0.015034594,-0.021934224,0.0431454,-0.023234138,0.067052074,0.01594965,0.052075393,-0.049724728,0.010650448,-0.010062003,0.14186202,0.076772675,0.021980088,0.087951176,0.02811506,0.0035798256,0.029702216,-0.0015604959,-0.0013673587,-0.05671642,0.025982384,0.01414153,0.06911849,-0.03370301,0.02727853,0.025963562,0.006400407,-0.07253346,-0.0013702344,0.03188106,0.027485488,0.06351963,0.023176635,-0.046909515,0.0051696124,-0.08613313,0.013773278,0.06717288,0.017969312,0.012915517,0.12537608,0.07683893,0.013432109,-0.025317581,0.09341678,0.043802164,0.0026963945,-0.002948181,-0.09557496,0.0038976006,-0.004094508,0.06931232,0.11285905,0.013087769,-0.0022617343,-0.03141832,0.025357105,0.05979857,-0.023661256,0.06580459,0.06944366,-0.0032553629,-0.045403723,0.009393881,-0.05165856,-0.11253338,-0.02293264,-0.051996186,-0.040735118,-0.013038034,-0.12142323,-0.061194222,-0.03451216,0.08409705,0.098775156,-0.032971315,0.08896547,-0.018175984,0.09072474,-0.06680871,0.035812113,0.056913015,-4.5060695e-08,0.0016816526,-0.08334235,0.046330422,-0.019410826,-0.00225283,0.0050296653,0.015005384,0.0068739746,0.03163451,-0.059998337,-0.029361494,0.009130925,0.01425385,-0.004742715,0.0587531,-0.008271724,-0.008409619,0.07659564,0.0060249353,0.034269057,-0.041080855,0.053084716,-0.07893131,-0.029405048,-0.03580389,-0.04353186,0.017216671,0.062446304,0.08104487,0.00015708308,0.07396004,0.063559406,0.022620294,-0.0873277,-0.12630808,0.074627966,0.039314836,-0.042654134,-0.010487746,0.033528812,-0.06895348,-0.007541387,-0.049235716,-0.0071514803,0.033646557,-0.059652973,-0.031394817,0.09164961,0.043594997,0.006650274,0.025367774,0.010530519,-0.0010002183,-0.09339508,-0.021780742,-0.049091347,-0.0336564,-0.056812238,-0.004620091,-0.0013058692,-0.03926413,-0.048229985,0.18051791,0.016471941 +2.1.1.214,"In contrast to the archaeal enzyme tRNA (guanine10-N2)-dimethyltransferase (EC 2.1.1.213), tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA. ",384,1.0,-0.04152001,-0.04267019,-0.12900883,-0.07726058,0.00852095,-0.013245157,-0.024402237,-0.0014606293,-3.6628717e-06,-0.053620495,0.053250458,-0.02762604,-0.088842094,0.007822663,-0.036989518,0.013431388,-0.091061965,0.018970331,0.03711904,-0.010428586,0.041827243,0.094826005,-0.010726173,-0.0031063634,-0.0013361827,-0.022708315,0.013624863,-0.069837175,0.069165945,-0.0425436,-0.04310381,0.006735219,-0.03021701,0.01690789,0.012986338,0.057820357,-0.048915006,0.030448973,0.02732403,-0.00979376,0.038370866,0.014014537,0.018630436,-0.013771936,-0.057358515,-0.00047628797,0.07258723,-0.025782341,-0.05188177,-0.011426533,-0.014619149,-0.035734724,0.002727997,0.011855387,0.029148081,0.061987095,-0.022812445,-0.06553349,0.015990663,-0.006497927,0.060158953,0.004323387,-0.008800855,-0.05050084,0.0354258,-0.037056815,0.092932895,-0.028840704,0.0137193715,-0.024387844,-0.029271584,-0.04488685,-0.07550288,0.039554264,-0.07450591,0.09757512,0.043957353,-0.004287281,-0.01908355,-0.0050657084,0.014873578,0.03650308,0.031832263,-0.073965155,0.05359313,-0.032004256,-0.026030349,0.12950306,0.04850959,0.08263493,0.04324848,0.10053993,0.084249035,-0.030954482,-0.084078774,0.07064151,0.0136095565,0.078460425,0.021925962,-0.029110124,0.011856687,0.0955556,-0.08345301,-0.027059307,-0.00015766552,0.023153687,0.07057779,0.030698264,0.005395526,0.012279981,-0.0005894065,0.05795753,0.05457926,0.04897262,-0.018674534,-0.00080140174,0.021957273,-0.009308822,0.0038935272,-0.013102429,-0.08628336,0.010658106,0.038069963,-0.0032450838,-0.050922427,0.009102329,-0.05830517,4.39221e-33,0.00728197,0.02610237,-0.03533964,-0.040361296,0.09444919,0.030682804,-0.07071368,0.029428372,-0.00478221,-0.037413973,-0.10275999,-0.07124782,-0.027240895,0.028353654,0.0029481782,0.03781481,-0.014661369,0.007713931,0.033551794,-0.062045306,-0.03681533,0.022812234,-0.03592567,-0.027542887,0.022312108,-0.00096448115,0.03739811,0.03314098,0.005422736,-0.055975944,-0.012966173,-0.12834422,0.013781714,0.02056009,0.115441464,-0.014814496,0.04339114,0.035384968,-0.019506631,0.07702306,-0.016070731,0.026442325,0.0051831314,0.022449575,-0.035143793,0.01110921,0.00863701,0.011037906,-0.008192857,0.0017568456,-0.036525708,0.0046704477,0.0013003346,-0.022472326,-0.036651228,-0.011865761,0.017515188,-0.017208522,0.0068804948,0.009995694,-0.030839294,-0.023283089,0.020890724,0.019727672,-0.0016461512,0.01077821,-0.05694847,-0.043814693,0.05298912,0.040218677,-0.014279832,-0.053057056,0.09616113,-0.022329027,0.09192617,-0.056172717,-0.087046556,-0.12088362,0.009663399,0.030970532,-0.019021835,0.043221276,0.033559427,-0.039817158,-0.024348537,0.0021184492,0.0017390402,-0.058550227,0.043376278,0.03815998,-0.034290183,-0.032376654,-0.02557366,-0.037807755,0.04574568,-4.2157654e-33,0.034124684,-0.04839114,0.029324211,-0.078287266,-0.08959203,0.06492196,0.011380812,-0.07940453,-0.07842483,-0.10026121,0.12283343,0.014600928,0.016000813,-0.026660677,0.08431492,-0.051880118,0.03830861,0.0374489,-0.025484167,-0.056956876,0.05656923,0.01528694,-0.13785625,0.08600858,-0.00057675934,0.009939672,0.03450908,0.1040943,0.06731237,0.046460994,-0.04768062,0.018712113,-0.01708978,0.04313317,-0.022558983,0.016915696,0.032247942,0.015954707,-0.08093579,0.023315063,0.016535161,0.023885008,-0.052377917,0.045814313,-0.07115446,0.07604935,-0.03388657,-0.041844793,-0.04711821,-0.06389245,0.1327472,0.038649634,0.01912467,0.01470915,0.09319515,0.004374885,0.008575068,-0.016199607,0.0068647503,-0.02586033,-0.023651484,-0.052017607,-0.035720374,-0.06898745,0.030077782,0.06172435,-0.015743265,0.08867334,-0.007934687,0.022252591,-0.011932545,0.0067713326,0.0063827336,0.031963382,-0.07894315,-0.05685409,-0.039550703,-0.051402237,0.019668221,-0.10571018,0.05658241,-0.04336871,0.0022094985,-0.06715586,0.0026452038,-0.04484425,0.04700472,0.11599935,-0.029429046,0.08369789,-0.015865345,0.009257429,-0.06103262,0.015255976,0.030317044,-3.6209272e-08,-0.04292216,-0.04915116,0.011160007,-0.01046822,-0.023366624,0.09052603,-0.037203003,0.06255723,0.05671608,0.014973632,-0.029128512,-0.019454163,-0.03313769,0.118739784,0.0053178356,0.05974627,-0.032260604,0.013663021,0.042052522,-0.01649662,-0.122563824,0.1120563,-0.14210945,-0.014790164,-0.030751342,0.0074810204,-0.0065169483,0.13523939,0.05428934,-0.06211113,0.052901585,-0.012305474,0.02243058,-0.002346537,-0.020730326,0.007366224,0.05576948,-0.102501765,-0.0044939136,-0.016298138,0.03136671,0.048853982,-0.07981438,0.0434426,-0.053535666,-0.05151763,0.006470829,0.08048505,-0.029222962,0.05911367,0.12761231,0.022724982,0.013303626,-0.04970396,-0.02972048,-0.07445301,-0.032690607,-0.05875997,-0.10595771,0.06604625,0.06466019,-0.046258792,0.13263087,-0.112213254 +2.1.1.215,"The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216, tRNA (guanine26-N2)-dimethyltransferase). However, it catalyses the double methylation of guanines at both positions 26 and 27 of tRNA.",384,1.0,-0.0771794,-0.07147455,-0.13128953,0.009662692,-0.01802164,-0.03837303,-0.012796914,0.0036204897,0.042831205,-0.05357552,0.061705656,-0.07187359,-0.053990904,-0.027886976,-0.11039985,0.039906062,-0.0966565,-0.016480783,0.04853395,-0.042796265,0.0468032,0.032169845,0.00080795254,0.01716591,-0.0020798251,-0.0010847275,0.014919681,-0.026340118,0.03632561,-0.12628746,-0.03438695,0.027454361,0.053146526,0.022551842,-0.01385478,0.12042964,-0.04846269,-0.0052057626,0.017472599,-0.057478137,0.056026604,0.022511782,0.046425983,-0.031033643,-0.10166078,0.0041657393,0.04763669,-0.0048439326,-0.001514755,0.04258199,-0.039314613,-0.03546728,-0.031175632,0.032913007,0.013651512,0.027217992,-0.046493445,-0.09226659,-0.040843133,0.0030482078,0.051889285,0.016930915,-0.009644062,0.015147848,0.00388338,-0.010692832,0.10621206,-0.091333434,-0.015416216,-0.08650206,-0.07009669,-0.046274878,-0.03297687,0.053042468,-0.06866788,0.15455039,0.0069934092,-0.011663492,-0.010004534,-0.0036668195,-0.017793506,0.013117268,0.07781085,-0.016817136,0.046818014,-0.039081886,-0.021165853,0.030553801,0.078959964,0.07082358,0.07625292,0.101711474,0.070286915,-0.024031669,-0.10043677,0.06433627,0.050667092,0.07240327,0.025996262,-0.025607195,-0.028853092,0.10749136,-0.04275507,-0.004587501,0.008532302,-0.005176796,0.0024864536,0.016219324,0.089220144,0.0061856513,-0.033492554,0.034833524,0.071063824,0.0050593223,0.004375916,0.08123756,-0.011782932,0.0022424085,-0.012391362,0.04313687,-0.079581015,0.023871198,-0.0182784,0.044848498,0.012303855,-0.022505771,-0.15822844,3.8069384e-33,0.051556896,0.04861141,0.0040430254,0.034314495,0.06505792,0.006311027,-0.03534834,0.03672765,-0.059397697,-0.018709775,-0.12981373,-0.060681455,-0.006852063,0.015938718,-0.039051153,-0.04038664,-0.026031757,-0.079079844,0.04214768,-0.024058063,-0.03679532,0.002612,-0.019921837,-0.01837306,0.06991608,-0.003258731,0.07603376,0.04482786,0.039511904,-0.010695413,-0.03353204,-0.119445086,-0.108967066,-0.010510471,0.07120409,-0.021234473,0.02643187,0.04007581,-0.086972244,0.07967331,-0.032404315,0.024443077,-0.0040561655,-0.046395816,-0.021325137,-0.048197784,-0.028921371,0.038079534,0.05509498,-0.0038284666,0.0037725982,-0.022332078,0.04358218,-0.03236591,-0.06115846,0.0018826362,-0.01600314,-0.006477512,-0.0020101585,0.06780745,0.025301537,-0.010492037,-0.007646113,-0.0028445534,-0.007794274,0.07224758,-0.04710198,-0.03981697,0.016159533,0.05680256,-0.034817286,-0.050051082,0.12913474,-0.044365533,0.011499376,-0.066727154,-0.09992563,-0.10670244,0.029863462,0.010117367,-0.046040095,0.029753985,0.06740578,0.011963302,-0.077452816,-0.008404086,0.0458572,-0.0036195554,0.030856958,0.016715735,0.03030596,0.016373875,-0.028306061,-0.06885899,0.03347353,-3.109531e-33,0.059161812,-0.085783064,-0.010881889,-0.07850023,-0.026805976,0.07223636,0.05565033,0.0059482506,-0.028848188,-0.05941027,0.12089221,0.0541045,0.033666477,-0.06814197,0.06973221,0.011413674,0.090874076,0.0696113,-0.008199634,-0.04516253,-0.03445405,0.026926268,-0.05381565,-0.010154676,-0.017189162,0.04095767,0.0057695596,0.092982136,0.0155175375,0.053172514,-0.059125748,0.025512144,0.012967907,0.040003516,-0.04906054,0.015997605,-0.018265398,-0.022644376,0.00096957065,0.026008029,-0.0020152284,-0.02744762,-0.014685535,0.061679278,0.011265277,0.0842097,-0.05223804,-0.031166114,-0.044606447,-0.08588352,0.099486426,0.05361013,-0.0012574437,0.057053097,0.059127826,-0.013823667,-0.008640019,-0.040200986,0.0019369968,-0.0152770495,-0.007674685,-0.0145483725,-0.014606243,-0.059707817,0.054218814,0.072917566,-0.057114247,0.046403628,-0.019066846,0.007864108,0.06289581,-0.0174884,-0.03648036,0.023144573,0.01817538,-0.057889152,-0.0013505721,-0.02480249,0.0026450176,-0.08341132,0.039622918,0.0011480037,-0.008665661,-0.042148706,-0.010321959,-0.02778899,0.073731534,0.09457717,0.013291506,0.06434041,-0.026272172,0.008203632,-0.04785064,0.025474744,0.11800056,-3.9036017e-08,-0.060116984,-0.07961193,-0.023266558,0.006755685,0.025646018,0.09984622,-0.038479626,0.046429694,0.042131662,-0.05757971,0.022738606,0.00723746,0.023875887,0.116180845,0.04257396,0.026325857,-0.045039743,0.045767404,0.017126083,0.04077845,-0.08105882,0.070528686,-0.12328167,-0.018711234,0.034604117,-0.015322329,-0.04916391,0.011232712,0.0049842084,0.014164872,-0.037602033,0.006234564,0.019241886,-0.055772997,-0.021646207,0.025528824,0.003413181,-0.07973754,0.005190226,0.02540478,0.025311384,0.0055712853,-0.082637794,0.015288239,-0.017696543,0.020036785,-0.0063413004,0.025468256,0.00863605,0.07259023,0.05839971,0.03928797,0.03271106,-0.025036026,-0.06431763,-0.10114905,-0.021118652,-0.052590217,-0.05995441,-0.03338267,0.07029696,-0.017694684,0.12292481,-0.10286176 +2.1.1.216,"The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions. In contrast to EC 2.1.1.215, tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase, this enzyme does not catalyse the methylation of guanine27 in tRNA.",384,1.0,-0.057261486,-0.04356196,-0.086790666,-0.017192177,0.02383647,-0.040422242,-0.015929872,0.00025989834,-0.016517732,-0.04289327,0.07494019,-0.06364129,-0.07213733,-0.043116465,-0.013266308,-9.98855e-05,-0.1250628,-0.030855406,0.029565636,-0.03417168,0.031952437,0.039706532,-0.043329548,-0.0058960137,-0.009687108,0.06309802,0.030864937,-0.023806404,0.07346354,-0.086493306,0.0063125514,-0.00842928,-0.0068199527,0.048667375,-0.03169094,0.0966042,-0.08615533,-0.035408128,-0.013563636,-0.0043543377,0.022054525,0.027606068,0.009003655,-0.06336241,0.0186901,-0.05000326,0.029857362,-0.009224772,-0.10234592,0.010072404,0.01023025,-0.08461671,0.008009903,0.014387122,0.03522794,0.05324979,-0.04141791,-0.019221405,-0.007013323,0.047173478,0.09494399,0.008869459,-0.044238936,-0.07826217,0.05780961,-0.07663601,0.095829934,-0.07490998,0.023310538,-0.03978829,-0.056722496,-0.0500347,-0.05224036,0.054054916,-0.05363356,0.05896523,-0.008432231,-0.017576324,0.026617894,0.009201847,0.018575005,-0.019434521,-0.005020394,-0.034266684,0.07139599,0.0037151182,-0.027671872,0.056182418,0.07587748,0.04305509,0.08267878,0.07516999,0.03217386,-0.0057156784,-0.066617034,0.06612692,0.015934644,0.08915449,0.043977853,0.023367882,0.01099763,0.09468474,-0.117079645,-0.03013098,-0.02912395,0.007855477,0.070918776,0.03427533,-0.034096975,0.03269124,-0.006712671,0.059404794,0.069704324,0.042682067,-0.0037890368,0.10087023,0.035447113,0.00056790415,0.06826253,0.018548286,-0.03873958,0.044054143,0.024036117,0.021835705,-0.049967702,-0.0069989483,-0.10088837,4.114468e-33,0.012002926,0.012482723,-0.01012224,-0.0333718,0.06420702,0.05588805,-0.08837587,0.03720632,-0.011406643,-0.037874848,-0.07477653,-0.06137494,0.029109605,-0.028491182,-0.023690157,-0.013827333,0.003705848,-0.01341442,0.039381675,-0.09809609,0.014371527,0.011081361,-0.05983485,-0.004230629,-0.0040543457,-0.0125117125,0.04689079,0.032664847,0.034927092,-0.02063025,-0.04924422,-0.10800813,-0.0043246085,0.024169382,0.073948294,-0.03685266,-0.009936904,0.047122452,-0.023101943,0.059828475,0.024188945,0.026431521,0.027412884,0.0108949905,-0.054948788,-0.016025286,0.004218958,0.07403388,0.05489703,0.0020792643,0.015172822,-0.044902753,0.0027380607,-0.01956821,-0.033417735,0.02359192,0.005241795,-0.030264655,0.020567961,0.03924204,-0.004758048,-0.0020561991,0.023281762,-0.0074610175,0.0007233557,0.009206476,-0.10055376,-0.013129542,-0.0006718332,0.054103795,-0.05864773,-0.026110137,0.1518056,-0.05108666,0.056455933,-0.07273604,-0.12576926,-0.06787667,2.5468877e-05,0.03558248,-0.059916396,0.068936095,0.048447203,-0.04319771,-0.0811454,-0.02884675,-0.0029352407,-0.055147916,0.019863212,0.075333804,0.010201212,-0.020662025,-0.06653541,-0.018294213,0.07836722,-3.810452e-33,0.024816517,-0.010720601,0.042521782,-0.06945883,-0.036807448,-0.0073060635,0.029777706,-0.058665246,-0.029338304,-0.09383802,0.12278359,0.015007244,0.019769607,0.010697793,0.08040953,-0.036025226,0.01878083,0.059075408,-0.0031687773,-0.034083605,0.029939793,-0.01955051,-0.09046782,0.04744207,0.009549894,0.021918474,0.046284456,0.05960643,0.10016822,0.054742996,-0.07708535,-0.032791622,-0.012969553,0.0577111,-0.028342623,0.028337404,-0.0067882272,0.0077863657,-0.031957988,-0.011427367,-0.018153178,-0.016317125,-0.02381006,0.10327825,0.008744666,0.0874154,0.04308007,-0.049776744,-0.07222569,-0.098501466,0.07495292,0.027775578,-0.028009301,0.035933577,0.05061657,0.02524461,-0.013569861,-0.037964035,0.0028806392,-0.0047414177,0.035436306,-0.059098806,-0.044730205,-0.05556103,0.019782994,0.0006020219,-0.048725497,0.10868213,0.048476372,0.014557874,-0.0006226036,0.01061918,-0.018119778,-0.01653346,-0.07320671,-0.06544919,-0.03854976,-0.013204636,-0.006521966,-0.13377915,0.053728342,0.00442611,-0.048280172,-0.072939746,-0.006596673,-0.024531793,0.04107871,0.10977026,-0.021425018,0.07505491,-0.058899842,0.018883586,-0.0468107,0.06296364,0.04503968,-3.5296946e-08,-0.055553876,-0.1057563,-0.024830345,0.03215005,0.02981513,0.13877375,-0.059247617,0.04887458,0.05724945,0.0011872934,-0.045532532,-4.9853854e-05,-0.01086611,0.077460036,-0.0012888713,0.0680042,-0.052416082,0.041455194,0.027168468,-0.017180258,-0.06719091,0.057919607,-0.12845655,-0.018053355,-0.047473453,-0.0020675187,-0.028371964,0.16734657,-0.00906911,-0.061530203,0.03592956,-0.001822751,0.054950826,0.01507359,-0.0149719,0.013874213,0.031177912,-0.076780885,-0.023254411,-0.017024364,0.05019752,0.038617253,-0.10227178,0.034853045,-0.01831759,-0.030608855,0.0014679907,0.057803217,0.013993623,0.084726654,0.092955954,-0.0144686485,0.040306114,-0.012684936,-0.006187535,-0.05869961,-0.042180315,-0.04232029,-0.06711792,0.058173247,0.058117107,-0.04330736,0.12852943,-0.041881792 +2.1.1.217,The enzyme specifically methylates adenine22 in tRNA. ,384,1.0,0.019691061,-0.034013692,-0.09106033,-0.054696254,-0.02910426,-0.021117931,-0.024424147,-0.018528316,0.0074805385,0.0068507944,0.06162778,-0.04143791,-0.06552485,-0.023042422,-0.012677214,0.079662554,-0.10270757,-0.074780196,0.042047326,-0.0794193,0.023111407,0.11184821,-0.035911135,0.030426167,-0.03663017,0.01859303,0.05457969,-0.030374028,0.01736838,-0.018224679,-0.06274162,-0.00019598064,0.0070227114,0.010393564,0.0049984218,0.121203005,-0.14039816,-0.0018982884,0.06238282,0.012543177,0.070389114,-0.0076872124,-0.028643407,0.01252511,-0.07156143,-0.080403775,0.05406446,0.015182704,-0.013152123,0.06342953,0.026246306,-0.08325128,-0.009379392,0.01642141,0.037091415,0.050818793,-0.064412564,0.015924957,-0.013986949,0.011743567,0.035907336,-0.027956406,-0.032931957,-0.04950551,0.10196138,-0.04683428,0.060780082,-0.03160012,0.026520263,-0.07129895,-0.031406626,-0.052378025,-0.024444988,0.08439503,-0.049128626,0.0009878338,0.049328204,-0.053722702,0.024371548,0.018230528,-0.008091841,-0.006338898,0.047175713,0.009435367,0.09133824,0.008352203,-0.003139899,0.04465263,0.03451108,0.03366462,0.02584346,-3.549635e-05,-0.025128342,-0.022425374,-0.053998742,0.011429681,0.048687555,-0.016281916,0.034249328,-0.025950145,0.016563596,0.07100097,-0.08128523,-0.007962117,-0.06167304,-0.004290183,0.013342767,0.031181632,-0.071205914,0.04690818,-0.0005796725,0.09661484,0.05340093,-0.0006419869,0.06936759,0.08405117,0.01516281,-0.00082831713,0.052028906,-0.006266464,-0.10671819,0.033553466,0.050930396,0.045294672,-0.03900666,0.00921594,-0.12877102,-1.6536906e-33,0.035618816,0.0010815185,0.026204472,-0.031633854,0.06305862,0.008570323,-0.016460247,0.050450586,-0.012837667,-0.028442798,-0.103351705,-0.114339314,0.041696776,-0.07507457,0.020693626,-0.00068792346,-0.07192089,0.012994584,0.009830198,-0.06589314,-0.058110952,0.041896127,-0.025935259,-0.01937597,-0.014066358,-0.002736608,0.02708777,0.01565654,0.09802268,-0.021712665,-0.03145122,-0.06218958,-0.06600375,-2.7531914e-05,0.043805603,-0.013093877,-0.049935173,0.027456505,-0.040016726,0.08913001,0.03460445,0.009004973,0.057340514,-0.02556331,-0.01122588,-0.022843309,-0.018546922,0.056657106,-0.002116095,0.05944925,0.03926004,-0.020766549,0.0307273,-0.046487678,-0.06827057,0.021943334,-0.0077005345,-0.030006917,0.003640532,0.06779035,0.0020943307,-0.005449724,0.03089965,0.049321555,-0.05056732,-0.022135308,-0.09200615,-0.0965711,0.003463146,0.1080775,-0.036867686,0.010960197,0.14488612,-0.06593516,0.018130777,-0.009714811,-0.07968478,-0.007606352,-0.023492623,0.023363536,-0.0016594693,-0.010040796,0.050042853,-0.009654766,-0.06059736,-0.041348137,0.042663798,-0.05322117,0.005468964,0.055489797,0.03466557,-0.020485058,-0.099253125,-0.03358035,0.0137826605,1.6344123e-35,0.06581902,-0.06827948,0.09202355,-0.09437893,-0.0029679455,0.03380532,0.014628667,-0.047187544,-0.03199753,-0.06405798,0.13668387,0.07344748,-0.014641867,-0.021322254,0.06717441,-0.018854586,-0.013843592,0.03417098,-0.018870654,-0.028660847,0.031141208,0.02455286,-0.008003534,0.07785633,0.010561942,-0.042540077,0.0469113,0.09594728,0.08682081,0.03259735,-0.032677207,0.01740301,-0.01931795,0.060791783,-0.017396733,0.04649937,-0.021181341,-0.039113495,-0.020509906,0.017473208,-0.0018017255,0.018465087,-0.02369024,0.12806782,-0.06746901,0.08631779,0.0118591245,-0.024899581,-0.055941153,-0.047355633,0.08401424,-0.025205445,0.04703314,0.011851813,0.07054498,0.050582364,-0.050332814,-0.0026893797,0.007143459,-0.010296526,0.013318907,-0.04143368,-0.050166614,-0.032679796,0.0075489194,-0.04087649,-0.04233677,0.004546948,0.020674225,0.062227286,-0.0045990925,0.020995518,-0.026491033,0.021322949,-0.05913837,-0.050582286,-0.012411315,-0.027090354,0.008865359,-0.092283,-0.02707046,0.03999925,0.0059566875,-0.061784953,0.033227593,-0.013015965,0.022174202,0.12652244,-0.00719184,0.09707871,-0.037226982,0.021997277,-0.06228332,0.01937983,0.013735415,-1.7234974e-08,0.0028113418,-0.10129048,-0.020883255,-0.031878777,-0.014096951,0.13357174,-0.031351067,0.051130425,0.04069778,0.011952037,-0.045754384,0.01380213,-0.022664176,0.094102986,-0.010674327,0.01683826,-0.07506406,0.01066253,0.00053631805,-0.09926303,-0.14274187,0.059377708,-0.09402808,0.034285687,0.01857944,0.044539247,-0.015842127,0.15794718,0.0014567641,-0.00996637,0.032051016,-0.0078119845,0.052954808,-0.04461879,-0.03232837,0.062407378,0.039270353,-0.024397433,-0.051527347,0.028385516,0.045552943,-0.015999429,-0.0728269,0.017628592,-0.024211537,0.007928405,-0.025775732,0.08966305,0.022041338,0.0014935033,0.0537066,0.0049489113,0.016988672,0.013594066,-0.042952992,-0.013357831,-0.044824336,-0.13730586,-0.0655112,0.010544508,0.045427535,-0.009090824,0.16201475,-0.07358228 +2.1.1.218,"The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA [1]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of guanine9 in tRNA (cf. EC 2.1.1.221, tRNA (guanine9-N1)-methyltransferase). ",384,0.99999994,-0.060135778,-0.076742634,-0.13972959,-0.05307973,-0.027416317,0.029514015,-0.010145447,-0.002254747,-0.045125313,-0.023225797,0.058497615,-0.035258092,-0.082677536,0.0027104525,-0.04555345,0.047384754,-0.111675836,-0.015777146,0.06690323,-0.04859541,0.038097266,0.065994866,-0.060387667,-0.0055474313,-0.0027395682,0.027358377,0.017949,-0.05457507,-0.012786523,-0.011493421,-0.061307203,-0.012157871,-0.0036103742,0.06237615,-0.0005350267,0.09346758,-0.10431191,-0.01558064,0.055994608,0.018439831,0.07411791,0.026975948,-0.0055790525,-0.017571405,-0.04340385,-0.013323717,0.057304595,0.014884876,-0.036047067,-0.013654945,-0.020444054,-0.04277304,-0.036035035,-0.002749874,0.063706204,-0.027701281,-0.021460062,-0.04723178,0.002948115,0.01050683,0.043480944,0.023514414,-0.0012664716,-0.05250086,0.05387345,-0.047925636,0.06643738,-0.031676065,0.025558405,-0.07261965,-0.04404569,-0.033978853,-0.03720805,0.031117147,-0.07158706,0.095446065,0.022124557,-0.032694478,0.023142349,0.0068508773,0.032317355,0.0236852,-0.016868113,-0.011759832,0.065178126,-0.023633463,0.0064940606,0.050636753,0.07080151,0.065631755,0.06356231,0.041056532,-0.0046256077,-0.082803704,-0.091656275,0.018321361,0.016116176,0.035364784,0.032271456,-0.040437322,-0.009684125,0.049399078,-0.07731939,-0.038329694,-0.034133453,0.014048944,0.013770114,0.027574848,-0.015543462,0.039374832,-0.064175405,0.08180552,0.007742047,-0.02257036,0.016624589,0.044450864,0.027701916,-0.022891961,-0.042733025,0.002295883,-0.11941395,0.035103623,0.045702193,0.017444115,-0.057862345,0.0048278267,-0.09181615,4.5634054e-33,0.03421157,0.00885475,0.045939773,-0.068117835,0.06270334,-0.009325705,-0.10478438,0.07278631,-0.019927904,-0.033864412,-0.08951377,-0.06910759,0.021592043,-0.019167265,-0.02763818,0.058032356,-0.05396308,-0.025144959,0.035703868,-0.062218767,-0.06104441,0.011345676,0.0055038133,-0.009518513,-0.010882248,0.014940757,0.03340309,0.0092532,0.063104294,-0.0294388,-0.016285704,-0.11790794,-0.068424195,-0.0050984137,0.07285209,-0.0091872355,-0.039885983,0.018658523,-0.042378806,0.09226723,0.0031164833,-0.029470274,0.05293289,-0.0213343,-0.037247237,0.0013806137,-0.016239664,0.060412496,0.03035885,0.04206876,-0.0154092405,-0.035869177,0.019453721,0.00053727976,-0.063812785,-0.013903746,0.037462577,-0.03485323,0.0052356925,0.03119688,0.023551762,-0.019354884,-0.015849127,-0.047422253,-0.065957315,-0.018725138,-0.105083406,-0.02718412,0.049277302,0.039977886,-0.020766588,-0.053955503,0.08412401,-0.037147637,0.048162393,0.02458077,-0.055550482,-0.045096893,-0.007152923,0.010600189,-0.039594136,0.03836827,0.086590774,0.010105515,-0.06174137,-0.015744943,0.022746265,-0.02011737,-0.022995776,0.07222034,-0.028436523,-0.0055612084,-0.056983788,-0.012964697,0.027483884,-4.3917784e-33,0.097714715,-0.08770067,0.033780325,-0.12333238,-0.048881203,0.029021777,0.031288024,-0.055022262,-0.06982072,-0.07153811,0.11242145,0.013547742,0.076264724,-0.04391448,0.09935056,-0.019189695,0.04813535,0.09188409,-0.0077333017,-0.02971172,0.04503801,0.041527767,-0.044118654,0.020977931,-0.010988121,-0.0063616373,0.059257157,0.08911587,0.099158525,0.060996957,-0.06318858,0.019506542,-0.038807996,0.059798967,-0.013427394,0.019402118,0.04879067,0.03820935,0.021035718,0.041376732,0.025691662,0.038771626,-0.050384384,0.11578139,-0.0030799059,0.07571357,-0.013019368,-0.017703421,-0.045662347,-0.029253893,0.14843999,0.023789622,0.015421561,0.0023101524,0.052016173,0.060357913,-0.040791053,-0.049711946,-0.010912171,-0.041914165,-0.031913836,-0.053178273,-0.020665122,-0.07647141,0.00025465526,0.052081406,0.014791792,0.053446867,0.015851578,-0.054672755,0.008781636,0.011879437,-0.03103682,0.0014988501,-0.050891653,-0.05756155,-0.034245275,0.017939225,0.043152455,-0.031680398,0.046168085,0.018168718,0.003752301,-0.0452246,0.054498333,-0.0097683165,0.03900578,0.10159087,0.016100006,0.03598548,-0.043724205,0.041184116,-0.03576027,0.065884046,0.0010022299,-3.6259593e-08,-0.036718648,-0.08580621,0.047637213,0.0034196568,0.011527071,0.1364567,-0.025769234,0.04075675,0.04566828,-0.014064251,0.036139324,0.018777413,-0.038200527,0.10625545,0.03072748,0.014027883,-0.09891432,0.0032738408,0.02723734,-0.04783657,-0.13187903,0.028020835,-0.1406738,0.017831469,-0.0139542185,0.024154983,0.0005494522,0.08199309,0.012329079,0.00081325736,0.033453543,0.0076972917,-0.015177588,-0.038410343,0.019487325,-0.007443703,0.05956295,-0.042770904,-0.036065165,0.030699974,0.06283856,0.05086226,-0.08931077,0.04869878,-0.0007678942,0.0030564594,-0.027938861,0.12258162,-0.0032861822,0.07207351,0.12624723,0.033887886,0.01369158,0.0034365612,-0.082086824,-0.10208831,0.017543439,-0.12647533,-0.10738202,0.057446778,0.04114857,-0.009458947,0.15933987,-0.026307058 +2.1.1.219,"The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNAAsp). Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs.",384,0.99999994,0.013497893,-0.020694897,-0.12676173,-0.087324165,-0.014099844,0.0076548117,-0.01824391,0.01153417,0.006396044,-0.0035277873,0.021211568,-0.009571844,-0.039550565,-0.027355503,-0.06574431,0.04628256,-0.10363823,-0.098357156,0.09110808,-0.045251574,0.028462118,0.07213925,-0.03155895,-0.0018184482,-0.0061222333,0.015548796,0.048234187,-0.05165236,0.048160158,-0.043115743,-0.054442003,-0.013537124,0.03516283,-0.0341445,0.020752097,0.010182494,-0.070217244,-0.00059608376,0.05282212,0.030063825,0.03596472,0.036180183,0.0011881227,-0.012998542,-0.11815319,-0.038005423,0.07123758,0.066977344,-0.021938186,0.0052104723,-0.023553494,-0.046593856,-0.02414114,0.01588392,0.0026180292,0.10731323,-0.04451652,-0.047806922,0.021705728,0.008435919,0.11258054,0.045723617,-0.021117074,-0.033362493,0.100073025,-0.043628942,0.070756294,-0.0029545268,0.03549168,0.0024959736,-0.07249925,-0.017704658,-0.08148839,0.034134824,-0.02472802,0.03852028,0.09492279,-0.03820064,0.012295203,-0.048121274,-0.03587466,0.015420768,0.036393523,0.02362731,0.033757273,0.002927432,-0.043696206,0.11018988,0.13527362,0.04857885,0.04669018,0.011120654,0.012947729,-0.066581376,-0.058614537,0.091748804,-0.026711356,0.065007135,0.05600345,-0.031279948,0.014862696,0.034082066,-0.045507427,-0.02862071,-0.026519705,0.019252641,0.0017504157,0.03992685,-0.01646575,0.010100967,-0.01610997,0.03558168,0.07400823,0.021624455,-0.021797566,0.009267117,0.021346448,0.00057911937,-0.04061252,-0.044549998,-0.041581135,-0.003891542,0.017661512,0.0010901084,-0.0435742,0.04314594,-0.13120383,9.391712e-34,0.057256937,-0.008709491,0.027920531,-6.6254885e-05,0.08054869,-0.0064656665,-0.031692337,-0.0050631976,-0.026576359,0.01382833,-0.11389114,-0.115749635,0.006763104,-0.020029845,-0.041238856,-0.05159277,0.02389876,0.018063147,-0.0123296175,-0.0038598732,-0.087705374,0.10017333,-0.03774118,-0.072580606,-0.007898887,0.07318544,0.007903867,0.06241131,0.04025281,-0.02213993,-0.05324826,-0.093948536,-0.10545785,-0.017575493,0.124820255,-0.025182784,0.009426112,-0.0032498785,-0.04258487,0.093627535,0.031922217,0.075616874,0.01563483,0.019348906,-0.019327786,0.0010781536,-0.0542085,0.055870906,0.008890324,0.059247922,-0.029549763,-0.014584868,0.038600985,-0.056197543,-0.035113413,0.00230031,-0.035932098,-0.027344504,0.058355037,0.054670885,0.0013037535,-0.023678105,-0.021484487,0.031192552,-0.012111757,0.009248325,-0.08461115,-0.065308265,0.04113924,0.011621165,-0.051872525,-0.034007102,0.068225734,-0.023112258,0.053286817,-0.04563048,-0.06523067,-0.07231886,-0.004365953,-0.019459521,-0.02429239,-0.020660257,0.02940488,-0.053901233,0.008848109,-0.004436903,-0.014385985,-0.07831957,-0.023681864,0.062830366,-0.046937212,-0.026048413,-0.019882038,0.024280086,0.05534956,-2.704006e-33,0.0583265,-0.11703649,0.08506168,-0.117648974,-0.06510261,0.07066916,0.011907855,-0.11166921,-0.07628721,-0.08476131,0.073397085,0.044627216,-0.037789445,-0.03879595,0.041105166,-0.042185593,0.08935085,0.047766265,-0.0150274625,-0.03150388,-0.013833069,-0.000576174,-0.030606516,0.09287485,0.0029747225,-0.028099133,0.04398145,0.092976525,0.04742836,0.048263356,-0.0094712265,-0.014724115,0.032198716,0.046460103,-0.03595128,0.068184204,0.009627258,-0.04132572,0.062094927,0.047564387,0.053617474,0.031126665,-0.003239426,0.085131936,-0.064289145,0.07795739,-0.10290195,-0.019472351,-0.0847745,-0.060011856,0.07616153,-0.0141253965,0.040411934,-0.0018877622,0.07359252,0.056891777,-0.014949991,0.040146764,0.03606741,-0.016807355,0.016171608,-0.015221111,-0.039417997,-0.055280097,0.07165284,0.022873644,-0.04096916,0.075667806,-0.021696432,0.0074147894,-0.018231064,0.030518016,-0.036758546,0.015602873,-0.03838051,-0.027014634,-0.022333313,-0.10999803,0.037324566,-0.07730775,-0.039456666,0.015893135,0.016811987,-0.08382351,-0.00769225,-0.044984754,0.08637694,0.09562217,-0.026883716,0.07280164,0.03159176,0.0016401,-0.018740749,0.0632879,0.052711457,-3.5490242e-08,-0.03253959,-0.0748943,0.0049213907,-0.019656572,-0.039550234,0.11334875,-0.01747938,0.0033865902,0.084939286,-0.033300575,-0.012311738,0.016622633,0.038200013,0.09995141,0.010630445,0.016126595,-0.09203328,-0.022782663,-0.031478945,-0.0055953194,-0.06702711,0.075215146,-0.0946814,-0.0055828677,0.04753951,-0.027900374,-0.032849755,0.09989379,0.03478948,-0.004970318,-0.010467316,-0.0057541193,0.0028361427,0.0054112542,-4.0420007e-05,0.03018174,0.013482182,-0.056190114,-0.01904174,-0.0033667944,0.052224148,0.005463382,-0.073099814,0.005906564,-0.05828894,-0.003504575,-0.02781674,0.112830184,-0.08070952,0.03455353,0.0632312,0.03775641,0.042265076,-0.060284764,-0.0332405,-0.052595507,-0.035067488,-0.050921507,-0.08072073,0.036916863,0.014353575,0.008053117,0.108809255,-0.06904313 +2.1.1.220,The enzyme specifically methylates adenine58 in tRNA. The methylation of A58 is critical for maintaining the stability of initiator tRNAMet in yeast [3]. ,384,1.0,-0.01791946,-0.07393079,-0.05629048,-0.04944286,-0.060481407,-0.011944849,-0.013053332,0.011428849,-0.012890409,0.021819372,0.05337992,0.008396838,-0.08275025,-0.027545596,-0.05899869,0.09915589,-0.10558221,-0.02128201,0.026890073,-0.07248682,-0.00063105446,0.10516447,-0.013111321,0.022670733,-0.012747529,-0.026733126,0.03176006,0.0224027,0.024435706,-0.107094154,-0.05346972,0.056337155,0.0073744105,0.008124374,-0.025876429,0.10928346,-0.07193562,-0.0021809698,0.0459008,0.025096398,0.08880195,-0.050905008,-0.021294767,0.027233185,-0.072748385,-0.0053568347,0.05041708,0.03269809,-0.009504754,0.020329567,-0.031403325,-0.083225556,0.011318407,-0.016351596,-0.05563804,0.048858285,-0.013188737,-0.025853613,0.020332221,0.005626126,-0.00591924,0.0062570153,-0.010357473,-0.022264061,0.10747512,-0.06692411,0.113874815,-0.028967816,-0.010950695,-0.010543302,-0.033412762,-0.050270326,-0.0044804527,0.0791687,0.013554598,0.041481465,0.029499782,-0.06707057,-0.005429349,-0.003333885,0.0033226018,0.00013364453,0.044274107,-0.018913282,0.062749535,-0.014469813,0.008517599,0.0856072,0.06329515,0.05638382,0.003188069,0.029887,0.0076695397,-0.018161558,-0.048978116,0.06540643,0.046006504,0.05235001,0.01393066,-0.051133793,0.0075055407,0.05946682,-0.102093,0.030252175,-0.0037159033,0.0010553596,0.019072486,0.0035092672,-0.01877033,0.039489105,-0.003513755,0.04627138,0.0858077,-0.027591046,0.029599877,0.044489495,-0.046344772,-0.012707413,0.051639955,-0.07012055,-0.0892948,0.020967735,0.03377546,0.021199865,-0.06211788,0.0034670564,-0.094495885,-4.495006e-34,0.011684653,-0.0025572467,0.009535596,0.030140346,0.019834395,-0.03394943,-0.018651411,0.016178757,-0.059741724,-0.073855646,-0.05209399,-0.12585382,0.028005771,-0.06662834,-0.0039552255,-0.0128104,0.0005325931,0.048995875,-0.056765966,-0.024915967,-0.0025023962,0.029245557,-0.043085113,-0.021309193,0.03697806,0.04207664,0.02196061,0.024937158,0.054607272,-0.023770852,0.0051773502,-0.07050797,-0.050005015,0.0012541392,0.088286735,-0.034848552,-0.02843213,0.041908573,-0.058362875,0.10991616,0.009053176,0.055712815,0.043309156,0.006280486,-0.03114919,0.025336975,-0.001735717,0.06581032,0.01835911,0.084249765,0.019576948,-0.002634178,0.00665451,-0.0028822578,-0.056532834,0.008121113,-0.04430401,-0.010494268,-0.0289376,0.0057168105,-0.03272909,-0.007668942,6.0624654e-05,0.049051825,-0.07251509,-0.020646244,-0.07980053,-0.09335548,0.012554524,0.11435177,-0.053913232,-0.026420543,0.11088179,-0.015324101,0.009323692,-0.039360143,-0.09389916,-0.034090377,-0.062458858,0.03202933,0.001695098,-0.022362946,-0.024856992,0.009008665,-0.081297584,-0.026408758,0.093930736,-0.031647943,-0.043576315,0.01840808,0.061717585,-0.024171116,-0.047793735,0.0040299827,0.039269287,-1.3082184e-33,0.08973092,-0.072250076,0.09679037,-0.038227096,-0.073076345,0.06918313,0.04118992,-0.045635287,-0.07705819,-0.103651434,0.13707142,0.05347371,-0.043250356,-0.02722537,0.062603585,-0.04803565,-0.009156949,0.050227292,-0.012106613,-0.0006227719,0.026319338,0.04632784,-0.07138216,0.119223386,0.036431566,-0.020412544,-0.010136869,0.09891762,0.106332764,0.016590726,-0.0579833,0.050777968,0.016769186,0.056117516,0.0012670419,0.04944198,0.00681566,-0.04232854,-0.034783527,0.062149588,0.01976071,0.07573591,-0.056283746,0.09809524,-0.060165267,0.10412859,-0.01600725,0.009157541,-0.006022573,-0.07099084,0.09204281,0.0025832064,0.026173502,-0.0047742617,0.099826805,0.059783492,-0.03333134,0.030378394,-0.016479278,-0.016220193,-0.020042632,-0.050541114,0.01742581,-0.02509127,0.02505341,-0.0009838471,-0.040304117,0.007051427,0.0356457,-0.009945092,-0.023537228,0.04121188,-0.0065533677,0.030332321,-0.032319665,-0.064526364,-0.01949019,-0.07691582,-0.026215753,-0.0589071,-0.06961089,0.04704554,0.011231659,0.0030122295,0.017565997,-0.013779261,0.07170072,0.1020388,-0.034689173,0.051042493,0.019720534,0.004452983,-0.049712896,0.04162853,-0.030800708,-2.6057803e-08,0.02364101,-0.11081364,0.018440396,-0.060036637,0.015489545,0.109368525,-0.018850373,0.0050421013,0.055495497,0.023043782,-0.053135805,0.024015067,-0.008859524,0.11979526,0.030280218,-0.00948729,-0.12462975,0.04085804,-0.022167431,-0.06717331,-0.15685004,0.014219995,-0.12624227,0.0015141931,0.028488211,0.045855165,0.018746732,0.15543166,0.029981945,-0.011047505,0.011988513,-0.021135632,0.0420839,-0.01620114,-0.021521581,0.07424631,0.011750639,-0.031394582,-0.05456919,0.04463989,0.043631952,-0.025854662,-0.055397984,0.02533819,-0.03823035,0.0013118607,-0.025621206,0.05787274,-0.00010809367,0.008437532,0.0430923,0.029829623,-0.007090988,-0.02042818,-0.06452141,-0.05127279,-0.03782081,-0.097595796,-0.04963301,-0.02711141,0.020535741,-0.028866593,0.101687044,-0.113059215 +2.1.1.221,"The enzyme from Saccharomyces cerevisiae specifically methylates guanine9 [1,2]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of adenine9 in tRNA (cf. EC 2.1.1.218, tRNA (adenine9-N1)-methyltransferase) [1]. ",384,0.99999994,-0.025572952,-0.052019253,-0.1201584,-0.06666212,-0.00013983369,0.014206356,-1.3931792e-05,-0.0035123269,-0.020610712,-0.0034162966,0.029077904,-0.04367974,-0.105578266,0.002750512,-0.040452886,0.04115643,-0.11878297,-0.014565718,0.083682716,-0.036993895,0.04435583,0.09126205,-0.022426754,0.004391852,0.00902166,-0.0121140955,0.027754605,-0.043777503,0.010644582,-0.022962775,-0.0661578,-0.01207503,0.0029036324,0.06986905,-0.005163107,0.09941386,-0.05874549,0.004501261,0.057372995,0.02533573,0.0798053,0.004722991,-0.017285245,0.0013434438,-0.06246604,0.016820004,0.067034,0.0034402225,-0.038305417,-0.0049370877,-0.008769787,-0.060896773,-0.0126771,-0.019885305,0.054283656,-0.019249203,-0.017478254,-0.060309205,0.008241876,0.009217446,0.046678692,-0.0078585325,-0.015882561,-0.022073625,0.060078252,-0.06528761,0.08016312,-0.027345601,0.006881008,-0.073417775,-0.016367627,-0.05229728,-0.057814494,0.015532991,-0.037084673,0.073544286,0.046028607,-0.041437592,0.008321083,0.010184512,0.030438492,0.037669554,0.03993677,-0.028399447,0.07552445,-0.016823571,0.005331221,0.07753381,0.08828997,0.05846716,0.019427808,0.05698522,0.026188383,-0.06398015,-0.06352534,0.036582824,0.018939009,0.020812025,0.06600043,-0.04426576,0.0009960725,0.07499069,-0.067575134,-0.010040321,0.014398236,0.03772945,0.033902414,0.05289007,-0.020175302,0.0334547,-0.049136538,0.08557196,0.029438697,-0.02230865,0.021884428,0.0155031085,0.027425636,-0.017210715,-0.020042412,0.002139622,-0.10961807,0.05153252,0.035525504,0.044921976,-0.087127216,0.025064966,-0.08515252,3.796191e-33,0.0007127478,0.019061485,0.012308818,-0.061321553,0.08064955,0.013257728,-0.086099595,0.053997505,-0.04028237,-0.053683087,-0.08676027,-0.066130534,0.017704329,0.004290825,-0.024251914,0.008558056,-0.030036151,-0.006417298,0.03764713,-0.073492676,-0.05748223,0.008365166,-0.014728903,0.017077835,-0.008371884,0.01229083,0.030822976,0.047404997,0.0660791,-0.057360634,-0.04589329,-0.09259295,-0.060657956,-0.02058366,0.0700082,0.005542914,-0.035611015,0.032665957,-0.03297048,0.1204457,-0.0076231835,-0.014700574,0.037920415,-0.04846522,-0.03343004,0.014174689,-0.025561428,0.053564504,0.015675439,0.053105835,-0.021346347,-0.02282606,0.017497405,-0.007684181,-0.06876953,-0.0039001447,0.03741603,-0.032767095,-0.017236162,0.031945284,-0.022934323,-0.0070785764,-0.0040790364,-0.0026976021,-0.06374633,-0.039300933,-0.07692798,-0.060246646,0.0346277,0.05934005,-0.031841073,-0.026520096,0.109637976,-0.060246646,0.051755868,0.0018539382,-0.098842524,-0.06967585,-0.025512742,0.01926954,-0.015337921,0.044810012,0.058668803,-0.010468624,-0.049759887,-0.026313027,0.011704408,-0.023468561,-0.03185312,0.04147686,-0.025646865,-0.02737318,-0.029078944,-0.013352162,0.008199473,-3.8706002e-33,0.09409756,-0.07080177,0.056873415,-0.103593566,-0.060354207,0.05176539,0.0129318,-0.079477176,-0.09188964,-0.0887188,0.117226884,-0.016853474,0.05379749,-0.039524168,0.078402124,-0.03864986,0.011748503,0.1014759,-0.017736066,-0.03432327,0.056676045,0.046564363,-0.0638934,0.048930284,0.0102275,-0.020194117,0.04620982,0.11748685,0.09625481,0.032876633,-0.09395455,0.01908692,-0.026444783,0.053978063,0.014902747,0.041256532,0.039444905,0.05037302,0.0094617,0.033562522,0.044463143,0.06479218,-0.085411325,0.108989485,-0.026891546,0.1048454,-0.010645467,0.013086007,-0.033063047,-0.045173462,0.1091995,0.007237441,0.010044856,0.0071413894,0.06598298,0.039089754,-0.02875427,-0.033689775,0.00495421,-0.046377238,-0.027818851,-0.051795546,-0.0032321366,-0.049456645,0.02602174,0.025882274,-0.021366328,0.04274062,-0.0014447526,-0.023286965,0.012355483,0.038616415,-0.013137538,0.006469746,-0.051545855,-0.061879277,-0.0319758,-0.036740974,0.019949049,-0.04959982,0.049415197,0.005367306,0.031246305,-0.03253627,0.025341887,0.0014557608,0.054992784,0.07812685,-0.013344244,0.04797648,-0.038859375,0.031413842,-0.011795257,0.060840078,-0.0025437735,-3.656831e-08,0.0070346785,-0.07639965,0.049928073,-0.06140545,0.017184895,0.12992053,-0.010347924,0.027939357,0.038530603,-0.012753267,-0.014811743,0.016351739,-0.005859935,0.1098327,0.036259674,0.00949996,-0.084767476,0.0034959577,0.03366778,-0.07245603,-0.14196604,0.035640474,-0.14090656,0.029414391,-0.028379014,0.030131467,-0.014741326,0.1175091,0.053286776,-0.016076175,0.022150194,0.007999174,0.006224241,-0.031187538,0.004128674,0.0016502703,0.03549941,-0.049155366,-0.05812776,0.021689713,0.048666343,0.028901896,-0.07245872,0.033661053,-0.04249043,-0.010296664,-0.020585092,0.11150406,0.01705261,0.05321128,0.12914975,0.037649885,-0.0053855684,0.0043766117,-0.0939293,-0.11320877,-0.032223728,-0.11211173,-0.11556351,0.027493266,0.039880186,-0.01387787,0.16713677,-0.06615631 +2.1.1.222,"UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli. The second methylation is classified as EC 2.1.1.64 (3-demethylubiquinol 3-O-methyltransferase) [2]. In eukaryotes Coq3 catalyses the two methylation steps in ubiquinone biosynthesis. However, while the second methylation is common to both enzymes, the first methylation by Coq3 occurs at a different position within the pathway, and thus involves a different substrate and is classified as EC 2.1.1.114 (polyprenyldihydroxybenzoate methyltransferase). The substrate of the eukaryotic enzyme (3,4-dihydroxy-5-all-trans-polyprenylbenzoate) differs by an additional carboxylate moiety.",384,1.0,0.00058074336,0.004732006,-0.12196474,-0.034918908,-2.9275325e-05,0.037799962,-0.07478947,-0.017979605,0.058950644,-0.09123022,0.055312544,-0.04779266,-0.043398287,-0.019656898,0.04335381,0.035253555,-0.11305741,-0.014254114,0.0012552238,-0.030062713,0.12549493,0.023469882,-0.019779967,0.000967859,0.019097019,-0.00643087,0.06579979,0.025473885,0.022240352,-0.06028782,0.008905519,-0.018555822,-0.00433203,-0.07408174,0.04016366,0.07359516,-0.014126195,-0.13641435,0.02953511,0.012046837,0.07033245,-0.0058310744,0.0062835296,0.037779216,0.018757666,0.05282162,-0.001954641,0.022439215,0.018826446,-0.09246989,-0.011409134,-0.005271543,0.04576884,0.035846144,0.04912541,0.038146276,-0.008496565,0.0538574,0.0058069318,-0.036349613,-0.021335553,0.03544333,0.044645857,-0.0062352405,-0.019888133,0.015406608,0.01598919,-0.085668504,0.010540189,0.007557781,-0.12107401,-0.08754859,-0.08271055,0.018991467,-0.0651136,0.0812344,-0.018238692,-0.00047765922,-0.0090666395,-0.051848315,-0.027557606,-0.024901412,0.08344674,-0.04249929,-0.0024489663,-0.028080089,-0.027247142,0.0010275994,0.029971806,0.059280083,0.031693775,-0.030392887,0.04381121,-0.0031362297,-0.0049036224,0.030691488,0.093873575,0.11731372,0.07922976,-0.05054531,0.045463875,0.08184217,-0.079636306,0.002319776,0.05670395,0.016828725,0.061641857,0.14772132,0.007450668,-0.003463214,-0.040989984,-0.009299408,0.05632552,-0.033844247,-0.022788398,0.058225237,0.080852054,0.0036813808,0.016096223,0.0044218968,0.014769203,-0.015099179,0.08317198,0.0045596394,-0.0044423845,-0.06630249,-0.15880658,4.300646e-33,0.07731896,0.03733119,-0.0073485523,-0.06189744,-0.030616283,0.016004773,-0.06855413,0.007302247,-0.08318193,-0.07419285,-0.027337091,-0.02609395,0.038970854,0.059670288,-0.008845619,-0.022197137,-0.060335267,-0.042057216,0.057321217,0.017436102,-0.049398083,-0.011428394,-0.036673013,-0.0054671764,-0.042585332,0.015451559,0.0063609476,-0.0110113025,-0.052054413,-3.4861416e-05,-0.067235835,-0.08974158,-0.1036062,0.030096728,0.028384687,0.00849646,-0.05371251,-0.014754063,-0.0017042612,0.05222598,0.048263878,0.02232374,-0.004715374,-0.056799557,0.06122683,0.016472504,-0.031502042,0.09523982,0.022049177,-0.0032464587,0.00975594,0.06873147,0.09206535,-0.029646032,-0.07342016,-0.015748397,0.030327203,0.022709735,0.0046039335,0.042303137,-0.07324363,0.035602294,-0.027379723,0.058504123,-0.03702573,-0.005057369,-0.05437165,0.006512206,-0.044473458,0.076371126,0.020262083,-0.06546002,0.09849032,0.049569964,0.059174463,-0.03669075,-0.08606969,-0.06198166,0.0668555,-0.013610061,-0.07362452,0.026933616,-0.019792495,-0.07779005,-0.048985027,0.037499197,-0.023525698,-0.017156094,-0.05284008,0.10936064,0.016414123,-0.005537237,0.02498039,0.028540324,0.02655995,-5.5928585e-33,0.04721603,-0.007857338,0.02373877,-0.11148383,-0.012243609,0.037281457,0.046769913,-0.0190376,0.015936801,-0.037766647,0.10842167,0.01239656,0.03404994,0.00086566416,0.02242959,-0.0053360886,-0.022047352,0.099023335,0.052618038,0.0101437755,0.09465918,0.022905938,-0.083303906,0.04932695,0.016114809,0.04787821,-0.0059992666,0.033896975,0.05085194,0.022056496,-0.037938956,0.0176295,-0.015672885,0.0007526437,-0.05460709,0.06204876,-0.08438479,0.015070025,0.027032332,0.017266747,-0.021212248,-0.0041015325,-0.0840146,0.036393296,0.05043264,0.1354845,-0.061787277,0.03043095,-0.012085229,-0.028992414,0.0012356385,0.032807495,-0.059266835,0.04570829,-0.056535836,0.05788445,0.031973105,-0.02606813,0.019103073,-0.003497224,-0.0120256245,0.017603075,0.054698117,-0.02155372,-0.021129211,0.029792337,0.016684232,0.031724464,0.015470578,-0.045088243,0.02089986,0.001938642,-0.015849259,0.008561253,-0.03954661,-0.011136906,-0.114061676,-0.05573085,-0.033196446,-0.013879084,0.011759311,-0.053666376,0.0362834,0.008711187,-0.08977135,-0.06563239,0.04272322,0.07358874,-0.09787131,0.04477593,-0.023312392,0.010236192,-0.05862748,0.07429106,0.03540631,-4.2983434e-08,0.027738716,-0.116759405,0.043979328,-0.049837925,0.022951344,0.07283579,-0.07730409,0.031911455,0.054173503,-0.048109893,-0.0050695958,-0.016081857,0.0018416798,0.042685684,0.031267762,0.021289356,-0.0038878752,-0.028452,0.031408172,-0.027625797,-0.09325971,0.029412167,-0.06661908,-0.013135706,-0.007079935,-0.03227341,0.030409705,0.10745805,0.016273616,-0.048404012,-0.009046662,0.063577674,-0.034598254,0.010599928,-0.072717585,-0.02876338,-0.027540302,-0.12820818,0.030106477,-0.013085162,-0.010405342,-0.041931346,-0.060510363,0.05848767,0.059394296,0.0027308564,0.031278018,0.05944625,-0.04631355,-0.09292616,0.054564413,-0.08386664,0.052552678,-0.04909365,-0.020990662,0.046132296,-0.08090046,-0.075195484,0.01678337,-0.051114775,0.022436494,-0.028238392,0.17814001,-0.08126399 +2.1.1.223,The enzyme specifically methylates adenine37 in tRNA1Val (anticodon cmo5UAC). ,384,1.0,-0.016227664,-0.048289396,-0.06547839,-0.030949043,-0.02273135,-0.046093196,-0.03930417,-0.022157295,-0.014475689,0.05006076,0.06915907,-0.081017345,-0.0644893,-0.03317038,-0.06602316,0.07691341,-0.055501413,-0.06353269,0.050549246,-0.022340028,0.03534548,0.122541174,-0.030738676,0.049404908,-0.035256155,0.05458294,-0.0006727422,0.007560276,0.018529074,-0.041787196,-0.07960165,-0.026478201,0.10025715,0.004319308,0.02015942,0.09120257,-0.11748047,0.00982216,0.06828188,0.023311367,0.031031707,0.031977743,-0.001011351,-0.007613209,-0.07291927,-0.06936796,0.029279793,-0.00019056542,0.0340495,0.06810702,0.042423736,-0.054145586,-0.061210953,0.03755511,0.033245366,0.03872726,-0.09765934,-0.005668488,-0.0038800852,0.031724114,0.07109041,0.021154782,-0.038003407,-0.017944938,0.06991467,-0.035668373,0.046183206,-0.038665805,0.017030742,-0.061783746,-0.028600916,-0.04076905,0.063640386,0.008475474,-0.02576705,0.016135134,0.04900603,-0.06906796,0.0003556953,-0.021229114,-0.024409827,0.01630848,0.034102563,0.011719517,0.07682638,0.03969078,0.012256347,0.046420857,0.05752953,0.046678327,0.0517748,0.021342166,-0.0016154896,-0.040175885,-0.011915085,0.015512803,0.055754863,0.039276972,0.00698292,-0.02446078,0.01398278,0.072304815,-0.10083284,0.000985012,-0.018104738,-0.0027866503,0.0025859724,0.013682901,-0.031825937,0.026121894,-0.014332766,0.08860383,0.0045659095,0.0041533406,0.0066257175,0.039335154,0.05184353,-0.0012862347,0.022985805,-0.0070004445,-0.04983596,-0.012742523,0.0637491,0.04874116,-0.042915132,-0.0421392,-0.078608856,1.3628785e-33,-0.0037685465,-0.036212143,0.03308325,-0.02241665,0.038483612,0.022383763,-0.052195292,0.035991978,-0.026995514,-0.05849881,-0.09672191,-0.08146994,0.068853684,-0.03478937,0.0014050667,-0.0088035185,-0.0835315,-0.01791557,0.0020384197,-0.07640369,-0.025511801,0.013420598,-0.05026373,0.012153581,-0.04197264,0.051869363,-0.009277307,0.036284618,0.13079995,0.005411345,-0.047012903,-0.032231193,-0.05242669,-0.021213278,0.058082517,0.040818486,-0.032617263,0.02686189,-0.012632056,0.114503406,-0.015535433,-0.009045379,0.005293016,-0.052376106,-0.03359226,-0.082431674,-0.023833152,0.07633914,0.04398236,0.05951611,0.0075705983,-0.063720204,-0.024756333,-0.037851598,-0.09006648,0.011973527,0.012739641,0.012047515,-0.009372164,0.053061478,0.017907824,-0.01555864,0.026656326,0.049690686,-0.07295734,-0.054737706,-0.086632155,-0.09474697,0.01771947,0.047962923,-0.044276167,-0.01819506,0.10073274,-0.016210869,0.008302006,0.0023274515,-0.045878712,0.006403819,-0.025982764,0.065508254,0.0047071963,-0.024801021,0.022789193,-0.023829632,-0.047244422,-0.0057102283,0.031024238,-0.060939018,0.029563367,0.059492268,0.04374836,-0.04934219,-0.11314929,-0.042343117,-0.011204199,-2.6318286e-33,0.09626093,-0.10573534,0.12358682,-0.06578551,-0.081193395,0.048472516,-0.016706035,-0.06268537,-0.05130883,-0.08589938,0.14726005,0.08098023,-0.032524697,-0.010575573,0.0292282,-0.0016042016,-0.014987886,0.036388043,-0.0053942213,-0.011087921,0.043118197,-0.002442011,-0.032598384,0.05617516,0.015899662,-0.009250277,-0.0049955617,0.053481504,0.0886775,0.048141956,-0.05895436,0.02688901,0.0019316337,0.055616397,-0.042533416,0.08015064,-0.009278588,-0.042757366,-0.030584443,0.045377716,-0.002189957,0.014291047,-0.022018848,0.06615407,-0.046658263,0.08089224,-0.0052493126,-0.022575764,-0.004819492,-0.04879995,0.11035475,0.026621053,0.03367714,0.023059307,0.10300595,0.0159753,-0.06692831,-0.014179636,0.0064436365,-0.023985352,0.015561518,-0.03678995,-0.017979756,-0.032164235,0.06299721,0.0075986674,-0.039897308,0.052247174,0.017723057,0.001309381,-0.0011461322,-0.00548016,-0.018955262,-0.052438997,-0.065606594,-0.09895086,-0.008812678,-0.024490058,0.00042741344,-0.08199122,0.0021652372,0.038721055,-0.002411273,-0.014398495,-0.011712368,0.0053008078,0.04706928,0.15084268,-0.061710577,0.084261164,-0.043957476,0.038498033,-0.03979065,0.018489545,0.052894253,-2.4861183e-08,0.020267457,-0.13184756,-0.006056556,-0.056165546,-0.016983274,0.14791662,-0.06571752,0.017598676,0.052815076,0.005544816,-0.009206589,0.035162214,-0.00023903667,0.07080538,-0.03479063,0.053998884,-0.08569784,-0.0070645614,0.02756069,-0.051959556,-0.15847054,0.03703568,-0.09254807,-0.05420449,0.007680677,0.015412246,0.009523832,0.13554703,-0.03246856,-0.00341916,0.015845304,-0.019077444,0.022778878,-0.04664094,-0.005729463,0.07670728,0.023228802,-0.00969935,-0.08491134,0.025010295,0.059549022,0.05323154,-0.078051336,0.024841227,-0.024931774,0.024399068,-0.011734143,0.12460416,0.017638355,-0.0027766859,0.033023667,0.051718377,0.022309812,-0.0119895255,-0.079755485,1.7592127e-05,-0.021925472,-0.10672014,-0.07625343,0.02853689,0.018005157,-0.04400073,0.14032388,-0.048834704 +2.1.1.224,"This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the appended methyl group. It contains an [4Fe-4S] cluster [3,6,7]. Cfr is an plasmid-acquired methyltransferase that protects cells from the action of antibiotics [1]. The enzyme methylates adenosine at position 2503 of 23S rRNA by a radical mechanism, transferring a CH2 group from S-adenosyl-L-methionine while retaining the hydrogen at the C-8 position of the adenine. Cfr first transfers an CH2 group to a conserved cysteine (Cys338 in Staphylococcus aureus) [7], the generated radical from a second S-adenosyl-L-methionine then attacks the methyl group, exctracting a hydrogen. The formed radical forms a covalent intermediate with the adenine group of the tRNA [8]. The enzyme will also methylate 2-methyladenine produced by the action of EC 2.1.1.192 [23S rRNA (adenine2503-C2)-methyltransferase].",384,1.0,-0.043264154,-0.055889986,-0.12923014,0.0035052109,0.064045064,0.023057519,-0.137216,0.04932005,0.08365603,-0.027056187,0.041140907,-0.032441802,-0.0034468644,0.077895425,-0.022854758,0.053584095,-0.13955554,-0.040089387,-0.019539643,-0.024826635,-0.014527438,0.073722266,-0.029582053,0.027593663,0.033020895,0.03933333,0.046368346,-0.024053728,0.006982608,0.002085622,0.0690036,-0.017401204,0.075328685,0.009701135,0.0050853444,0.12350501,-0.011226835,0.008377567,0.086123854,0.03448739,-0.030860916,0.014330045,0.020059342,-0.01837195,-0.028584322,-0.03796907,0.058945525,0.047913097,0.025703724,-0.024036633,0.023951983,-0.034667924,-0.050363053,0.023816062,0.06548226,0.056208726,-0.047631558,-0.052938435,0.023050169,-0.013779177,0.07921992,-0.05664333,0.009664328,-0.03291703,-0.02124538,-0.06880254,0.08327979,-0.043275796,0.037161816,-0.039951667,-0.06997866,-0.05503727,-0.01044591,0.053153533,0.0018910944,-0.009773591,-0.012801737,-0.037103392,0.060555004,-0.018709453,0.09313243,0.028390143,0.041559946,0.035108246,0.06914148,-0.010651509,0.0370996,-0.009721671,0.053135283,0.05142233,-0.01785809,-0.004227594,-0.027203009,-0.06552641,-0.04754299,-0.010909139,0.013941697,0.0570325,0.024380926,0.0053788973,-0.004832743,0.07317624,-0.086260274,-0.052936863,-0.04767615,-0.03887839,0.014038813,0.08522327,-0.009340553,0.04609661,0.07797953,0.11580548,-0.005751562,-0.04408104,-0.0023984662,0.09964341,0.036836144,-0.07624746,0.024290986,0.046747237,-0.026832089,-0.018160284,0.045159277,0.022460762,0.023950096,-0.022470972,-0.16375156,2.481834e-33,0.018851394,0.049634326,0.01676439,-0.034361586,0.038917065,-0.06556679,-0.05950806,0.020275585,0.0077319182,-0.00054418115,-0.066924155,-0.079487085,0.083660215,-0.050881285,-0.033590432,-0.06939594,-0.046373557,-0.029992651,-0.037565388,-0.053600192,-0.056177672,-0.008030876,-0.0415841,-0.021849196,0.008354774,-0.00865365,0.011010181,0.022834247,0.13610347,-0.01678468,-0.09285356,-0.019417707,-0.10401424,0.04216861,0.018527538,0.009576622,-0.085616365,-0.061931323,0.058769617,0.07963446,0.02037984,0.007550091,0.0040975777,0.010285501,0.06658165,-0.031407896,-0.06955071,0.055088792,0.0055142497,0.059207764,0.07698662,-0.050476413,0.04577129,-0.031603657,-0.07709943,-0.03606136,-0.04785429,-0.03729891,-0.0058307317,0.07668367,0.01792289,-0.010600001,-0.044093285,0.02545198,-0.014079225,-0.01540919,-0.054012064,-0.050192423,-0.016368054,0.090530604,-0.013437875,0.02994851,0.09581935,0.021980928,0.014829072,0.013211873,-0.012046423,0.064109534,0.026228065,0.016694048,-0.047420096,0.022409346,-0.0043572695,0.001971005,-0.07605006,-0.012134183,0.02077931,-0.07190442,-0.016630566,0.009864241,0.009300822,-0.1271187,-0.0132730855,0.017769694,-0.0061876783,-3.8478044e-33,0.04849365,-0.05884313,0.041775897,-0.12583661,-0.03466623,0.06482122,-0.008493613,-0.033323657,-0.012492678,-0.114417285,0.09419433,0.030215265,0.02343553,-0.009100653,0.027751945,0.006461733,0.00011783032,0.039596103,-0.06390696,0.0107972585,0.076633066,0.04208812,0.008030921,0.060772188,0.03005985,-0.03712377,0.027194142,0.053539347,0.0989846,0.077466376,-0.0036289534,-0.033777427,-0.05243255,0.039735623,-0.026806712,0.058703482,-0.02445585,-0.017687682,0.01268504,-0.0014495013,0.03648208,0.052712012,-0.021573734,0.18591668,0.017155845,0.090210766,-0.014079501,0.00021218006,-0.008732689,-0.11574736,0.014289613,-0.032650575,0.015716104,0.039057534,0.0006603038,0.08074357,0.055249408,-0.05447178,0.01761189,-0.044602178,-0.04346556,-0.06402541,-0.03492296,-0.019416964,0.036991715,-0.06713258,-0.055818547,-0.0046575274,0.004733588,0.046976775,0.00783041,-0.0046806056,-0.024666999,0.050002575,-0.043231037,-0.0076864064,-0.047641434,-0.04764405,-0.0338755,-0.014849058,-0.0003410574,-0.02326292,-0.017676154,-0.07855865,0.017316295,-0.06242111,0.10331233,0.053630505,-0.0061276057,0.015926542,-0.03309791,0.024615712,-0.0024119874,0.030056674,-0.008578463,-5.0873695e-08,0.033367045,-0.1105513,-0.0003361861,-0.03690853,0.034169283,0.12996742,-0.04715909,-0.028704483,-0.004073674,-0.03876479,-0.036466755,0.05035742,-0.04144398,-0.009609654,0.0065244394,0.03159075,-0.058641862,0.02479825,0.009066739,-0.07035112,-0.09991577,-0.009245543,-0.06454933,0.023081806,0.0071292445,0.012466433,0.04980998,0.09368848,-0.029834386,-0.04431896,0.05134565,0.014659666,-0.0071818684,0.02480778,-0.11232015,0.0014143798,-0.004470584,-0.043511763,-0.00094419566,0.08649222,0.06682421,-0.0034665393,-0.11467017,0.06305936,0.0038944678,0.022867916,-0.033759136,0.0052244766,-0.025178595,-0.021104518,0.11589607,-0.035312545,0.013637274,0.009854924,-0.06416738,-0.02068836,-0.110882916,-0.03300115,0.010929643,-0.019888667,-0.030375006,0.054250807,0.11957818,0.0076251305 +2.1.1.225,"The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis.",384,1.0,0.016236205,0.00073141966,-0.101950474,-0.10195312,-0.014408933,-0.021691382,-0.01088731,0.0007654657,0.04141606,0.033291902,0.06548389,-0.034207925,-0.058184527,-0.010571069,-0.09060295,0.042282663,-0.07341602,-0.0240887,0.024408517,-0.09586549,0.018911676,0.062053066,0.0041667167,0.02830038,-0.006643149,-0.02713263,0.011475433,-0.02382143,0.0065627294,-0.036645878,-0.10156981,-0.033648197,0.025318315,-0.011269039,0.038875386,0.09805492,-0.06612299,0.018894833,0.12012112,0.023369053,0.0811613,-0.002093482,-0.08595246,0.07920423,-0.035098296,0.021552198,0.08011242,0.012652285,0.022522563,0.048665997,-0.0041597183,-0.052642476,-0.009861764,-0.009776639,0.012999721,0.04127258,-0.092952706,0.0065604537,0.01068571,0.07684117,0.02405086,-0.027666446,0.029311538,-0.031272557,0.038437024,-0.063929,0.032327726,0.026084524,0.035600916,-0.029212367,-0.045260504,-0.01294824,-0.043023232,0.0810456,-0.031649824,0.018757103,0.024560614,-0.07647507,-0.041956544,0.046787057,0.029416101,-0.03989938,0.05509746,-0.034383163,0.05209707,-0.018157378,0.0075368914,0.031965584,0.047925916,0.04314099,0.06999303,0.03930287,-0.014288757,-0.04489598,0.004493533,0.00046306732,0.03309516,0.0062087006,0.08436681,-0.049674798,0.012324576,0.016736189,-0.014510827,-0.03482995,0.003032031,0.02537854,0.060000338,0.008607917,-0.054457948,0.055765927,-0.0055777393,0.062419686,0.027859444,-0.017841846,0.026107103,0.058018986,0.0031751215,-0.0014266584,0.00901706,-0.029401194,-0.094179995,0.053194094,0.07281186,0.059419814,-0.046177227,0.049070776,-0.07681631,1.9675524e-33,0.018528027,0.065704666,0.03984831,0.017789219,0.047791198,-0.022338416,-0.022283126,0.033032794,-0.057646837,-0.026824135,-0.1082301,-0.08707097,0.013552186,-0.0035591074,-0.006674718,0.01287436,0.0315418,-0.026660625,0.050237127,-0.032622427,-0.019305507,0.07273721,-0.0065972805,-0.016675368,0.04512636,0.0055786488,-0.0011014349,0.0062478553,0.09953384,-0.036097623,-0.050925236,-0.045393813,-0.07639518,-0.036423977,0.090876736,-0.020056851,-0.04141575,0.020796666,-0.04832674,0.063252375,-0.07399775,-0.010104987,0.06545357,-0.07180141,-0.041344482,0.02755093,-0.03878568,-0.010034173,-0.0016672648,0.05187661,0.017521763,-0.013599784,0.039266102,-0.0014794196,-0.04210981,-7.056444e-05,-0.0046427124,-0.036260393,0.0224579,0.06650535,-0.029471438,0.056469668,-0.025662575,0.033990733,-0.055877708,0.011886782,-0.12434228,-0.09498634,-0.026187105,0.08282983,-0.022197124,-0.034129813,0.12414748,-0.043591216,0.056184236,0.01347765,-0.120085664,-0.07343793,-0.048662033,0.033940297,-0.014046114,-0.02920319,0.008531533,-0.0458719,-0.040877976,-0.026641108,0.051750515,-0.02682387,0.035147823,0.055300232,-0.029206822,-0.042398155,-0.06263336,-0.024205454,0.011824438,-4.1361943e-33,0.11958885,-0.03799118,0.09092451,-0.048500873,-0.076324254,0.08054981,-0.025131013,-0.09596247,-0.012764061,-0.047636624,0.09273872,-0.014508418,-0.037307706,0.029231,0.011160486,-0.026601223,-0.053371157,0.04676057,-0.043341566,-0.03451318,0.012308262,0.0073766825,0.028995395,0.042020947,0.07208287,-0.043406993,0.07664829,0.119828105,0.05281696,-0.0012400226,-0.08501339,0.0139248315,-0.0020451965,0.024878526,-0.002465516,0.032386944,-0.02794958,-0.0055981474,0.010597889,0.023214675,0.016765397,0.042025324,-0.024394,0.09867781,-0.04219222,0.072773986,-0.020994103,0.0452668,-0.03683794,-0.07482635,0.10161891,0.020062061,0.0038862822,-0.014024899,0.0915594,0.05326232,-0.045295328,0.024629615,-0.004895897,-0.036835484,-0.030209964,-0.12568133,-0.042073898,-0.044564817,0.061189562,0.0003495823,-0.03345146,0.0059770504,-0.022963824,0.03886765,-0.029042104,-0.005953739,-0.018662568,0.030585274,-0.030685844,-0.00023142112,-0.0658834,-0.060334068,0.03639891,-0.05248668,-0.047901835,-0.011208002,0.04598657,-0.044150364,-0.007950479,-0.013920712,0.038823847,0.08739092,-0.021301568,0.075305074,0.011856327,0.019646486,-0.0038725329,0.04756199,-0.014151718,-3.234216e-08,0.046986222,-0.033118114,-0.0064089824,-0.06326532,-0.03681711,0.08999475,0.005660815,0.050779518,0.021470573,-0.010861859,-0.081551485,0.0657139,-0.014569249,0.059677105,0.03975617,0.080740966,-0.16115814,-0.036623716,0.048573326,-0.04592352,-0.081759945,0.06745395,-0.20319098,0.075986676,-0.042691894,0.0074207806,0.029997386,0.10694151,-0.0037804227,-0.006898226,0.0578304,-0.019904494,0.036185693,-0.06239531,-0.0018735247,0.024545778,-0.04275444,-0.052461047,-0.051069014,0.0293241,0.0021258981,-0.0013144418,-0.058830485,0.0034650553,-0.102178544,-0.014763125,0.011516055,0.06933958,-0.0017175011,0.017149422,0.054437507,0.04809991,0.012060405,0.01702657,-0.01594891,-0.003604509,-0.05339646,-0.11529847,-0.08624609,-0.04090049,0.0007749079,-0.055513285,0.17084982,-0.062005877 +2.1.1.226,"The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2'-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin. ",384,1.0,-0.033001274,0.022994725,-0.08872099,-0.07769538,0.010669464,0.024781408,-0.04929395,0.14054273,-0.028878137,-0.017074093,0.00405284,0.0039535207,0.14195389,0.10596557,-0.034919184,0.010395309,-0.07142919,0.0011337134,0.026954357,0.0018949123,-0.0048969826,0.12409165,0.0050240858,-0.02815973,0.01126655,0.04076802,0.028526243,0.038864747,-0.03652324,-0.035873905,0.03168816,-0.02445313,-0.01148792,-0.0685624,0.08542008,0.020444728,-0.033555347,-0.06771001,0.13944556,0.019088317,0.019651685,0.07641206,-0.0006157458,0.030334348,0.05126059,0.033927448,0.07680385,-0.0068398565,0.020032397,0.04408974,-0.035608586,-0.032341626,-0.00085970334,0.03450723,0.08520433,0.02130493,-0.052804537,-0.04790881,0.013252621,0.02285851,0.03972509,-0.071767926,0.05022487,-0.010915489,-0.037436455,0.0163909,-0.02012637,-0.0593461,0.012310526,-0.056466993,-0.10858423,-0.049028654,-0.07469955,0.062094517,-0.009397806,-0.029784486,0.011689349,-0.024599617,-0.08154742,0.059038524,-0.08937444,-0.15890737,-0.031869736,-0.040334594,0.024395151,0.0023153129,0.13131717,0.018732129,0.015801936,0.10852148,0.049484756,0.007530697,0.038492564,-0.065153494,-0.071773425,-0.07940498,0.056431986,0.0467644,0.018673683,-0.05392698,0.015262487,-0.015112861,-0.04026786,-0.0045657028,-0.021927718,0.026246289,0.009512316,0.015402274,-0.035941612,-0.035354223,-0.003313205,0.04352595,0.016642598,-0.031986907,0.024438197,0.08355545,0.10134249,-0.012791098,-0.048030484,-0.015327111,0.0055957907,-0.05953694,0.049557306,-0.013661404,-0.0746785,0.02889784,-0.08591449,3.996948e-33,-0.039865367,0.015691666,-0.0010424323,0.011745199,0.058160525,0.016196523,-0.037871875,0.032236002,-0.040930342,-0.09782143,-0.10633427,-0.0626426,0.056951806,0.01937594,-0.10352051,0.055076394,0.049646523,-0.02244685,-0.004353001,0.0037937183,0.060443763,0.022788718,0.0563149,0.020225884,0.013432451,0.025948586,0.0056874254,-0.0010481596,0.11342332,-0.062291887,-0.02022122,-0.05243929,-0.070946135,-0.01256179,0.0570194,-0.0020510193,-0.03469675,-0.03109174,0.08719911,0.046384014,0.0035222077,-0.025502145,0.01669655,-0.019209351,0.048936717,0.033750962,-0.003405486,0.030252952,-0.032795966,-0.0027920064,0.013685753,-0.029808661,-0.026737902,-0.0040790513,0.00058630895,0.0059972974,-0.002077083,0.06496257,-0.015289427,0.018569475,0.04745093,-0.029120462,-0.018966349,0.044682372,-0.0044146683,-0.010360699,-0.04100373,-0.02116745,0.024363322,0.0563552,-0.012680664,0.021547187,0.04561238,-0.0066341166,0.124794,-0.01102534,-0.122130126,-0.0830141,0.10550084,-0.005136647,-0.014955769,0.08655297,-0.0019162954,-0.06566328,0.045559328,-0.06995417,-0.006320139,-0.08510317,0.030770497,0.04103765,-0.009430685,-0.07271664,-0.06399121,0.008086461,0.0020220994,-5.768057e-33,0.107843295,-0.09803186,0.1068693,-0.06795576,-0.022474432,0.028606938,0.0019614869,-0.06381039,0.027208332,-0.08649173,0.05813658,-0.027669145,-0.017847106,0.009177655,-0.038779363,-0.054876287,0.028206112,0.050696407,-0.024386708,-0.019162914,-0.05443448,-0.011795759,0.027856259,-0.020686615,-0.023951856,0.013110552,-0.02646314,0.008273547,0.113986544,0.073843,-0.021321485,0.078226745,0.024753729,-0.083382644,-0.03027094,0.09543425,-0.049675718,-0.04467138,0.07665393,-0.01956705,0.013161148,0.048053715,-0.05993922,-0.029470779,-0.03919348,-0.014376624,-0.05113807,0.040075038,-0.05344751,-0.03154827,0.035396382,0.006533854,0.031809982,-0.009835478,0.0041048722,-0.007908384,-0.013147638,0.015877303,0.103891395,-0.06409163,-0.018595286,-0.055455547,-0.06793105,0.0044124727,0.014558175,0.062451933,-0.0069568763,-0.0010380115,0.088516235,-0.030023448,0.022125848,-0.077294104,0.011148503,-0.0035075573,0.012823262,-0.012440345,-0.10420566,-0.020773325,0.01258557,-0.02479239,-0.06154762,-0.0032567128,-0.006378107,-0.029038088,-0.055288337,-0.061799172,0.005814374,0.043931283,-0.038661458,-0.017039876,0.0006505852,0.013490261,-0.06057268,0.06407925,0.044140115,-4.2658744e-08,0.052668434,-0.012733175,0.01704995,-0.0051604123,0.025619434,0.054168534,-0.044737343,0.010364286,0.042962175,0.029070107,0.050784282,0.023427721,-0.016820826,-0.040055607,-0.0025399278,0.105102785,-0.081733085,-0.018835472,0.04887202,0.010209587,-0.057653293,0.06380194,-0.078524105,0.0434201,-0.031249102,0.0149345705,-0.015216947,0.0771428,-0.013515573,-0.041771837,0.055866085,-0.043933302,0.015118203,-0.07718333,-0.11111016,-0.052845415,0.017094858,-0.016788976,0.08296272,-0.004082087,0.092749275,-0.047763195,-0.10487779,0.05241992,-0.05784908,0.004201399,-0.008471617,0.01607855,-0.051161908,-0.060199533,0.059452575,0.013731541,0.010104682,-0.004876976,-0.029035717,0.062441457,-0.026683368,-0.015655905,-0.10513169,-0.024700252,-0.012827962,-0.04505235,0.15194833,-0.07818006 +2.1.1.227,"The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1409 in helix 44 of 16S rRNA and cytidine1920 in helix 69 of 23S rRNA (cf. EC 2.1.1.226, 23S rRNA (cytidine1920-2'-O)-methyltransferase). ",384,1.0,-0.045829866,0.015952064,-0.09136644,-0.07732376,0.0034714148,0.04526483,-0.045571927,0.13284408,-0.034842256,-0.004231275,0.009496258,0.012091884,0.09950482,0.08268437,-0.0106512755,0.05079746,-0.082344346,-0.0038449112,0.021521633,-0.017614309,0.0061779646,0.109266266,-0.015641527,-0.028103119,0.012195675,0.018318433,0.0540026,-0.020031353,-0.02775681,-0.03822178,0.026807657,-0.04730896,0.0026316994,-0.073813185,0.09511918,0.010027412,-0.031584773,-0.07269792,0.10277333,0.014296161,0.08055778,0.096630126,-0.0024010646,0.0058898567,0.039851148,0.030159237,0.06917954,0.0148530165,0.011223847,0.04998349,-0.027474439,-0.020554988,-0.028553823,0.025616309,0.083866484,0.013312638,-0.052288584,-0.02662595,0.016357012,0.015359812,0.055832997,-0.06122143,0.058393452,-0.015615515,0.012043801,-0.0132656135,-0.007031002,-0.047028005,0.02777592,-0.101409085,-0.08750134,-0.0477958,-0.084035605,0.06877355,-0.02993012,-0.04245497,0.026129035,-0.018445779,-0.049825422,0.06075835,-0.08811188,-0.14755748,-0.024467297,-0.04347236,0.022448402,0.019722605,0.08833423,0.047596186,0.016607232,0.09311682,0.03528247,-0.006723974,0.031008007,-0.06690579,-0.0635325,-0.07035453,0.096060134,0.06498104,0.026914217,-0.051470984,0.05975828,0.03557183,-0.018894386,-0.029954674,-0.06299526,0.028227786,-0.02164787,0.033471365,-0.0015065842,-0.02218428,-0.015425704,0.03812845,0.05900685,-0.031717867,0.030092277,0.06886113,0.06866828,-0.003701412,-0.027235862,0.039539933,0.011894872,-0.061993662,0.03360155,0.040580146,-0.07897782,0.033458523,-0.09396544,3.5129818e-33,-0.02697264,-0.012041423,0.017416017,0.013600626,0.03498609,-0.0012369457,-0.040862095,0.046331134,-0.049101666,-0.08355434,-0.11896057,-0.05933651,0.060655493,0.008110335,-0.12811492,0.053423934,0.029101752,-0.044350367,0.03401304,0.026211526,0.03742516,0.06175448,0.043199975,0.020036312,0.034176245,0.018605584,0.021168057,-0.007593755,0.07741323,-0.048150882,-0.022142041,-0.09141802,-0.10938692,-0.0063178907,0.06549646,-0.03169749,-0.019656422,-0.041498806,0.044272784,0.041013423,-0.0040619625,-0.044790722,0.022176623,-0.00855147,0.04936455,0.014245796,-0.006587688,0.023040356,-0.02508539,0.010160187,0.010389895,-0.018562367,-0.0030863269,-0.00086392305,-0.018270712,-0.0084299715,-0.02571212,0.039517228,0.017586665,0.040372357,0.058603805,0.0123263495,-0.037712622,0.058202006,-0.014000713,-0.029392792,-0.041925654,-0.020207686,0.04888697,0.054130774,-0.004530927,0.019967385,0.081673756,-0.03284781,0.13974936,-0.029167194,-0.12518606,-0.079263344,0.07079543,0.009508323,-0.001448239,0.07923885,-0.0035304353,-0.072703876,0.023135027,-0.068839036,-0.0034481287,-0.086902834,0.008921046,0.04336894,-0.011892265,-0.07595589,-0.06713475,0.023231208,0.0060010147,-4.7353203e-33,0.10277399,-0.13013901,0.09534713,-0.06637453,-0.012025315,-0.0151712075,0.025393559,-0.051750287,0.023558432,-0.04656274,0.07113767,-0.043939468,0.024023607,0.025335655,-0.0043643326,-0.022441559,0.028095225,0.08498847,-0.0025145626,-0.015274719,-0.053855836,-0.0019472701,0.016061574,-0.014050286,-0.026250279,0.031743143,-0.014574619,-0.009084925,0.12541237,0.046443474,-0.04621111,0.08481089,0.033794507,-0.06326774,-0.08319328,0.06354886,-0.022989083,-0.061010566,0.06652986,-0.026593618,0.014765265,0.07468385,-0.062409192,-0.018775258,-0.027157867,0.004138653,-0.05280525,0.034210373,-0.04407873,-0.004192538,0.038811594,-0.011167951,0.0023562852,-0.0067558195,0.023082763,-0.017808799,-0.031034106,0.045852184,0.08433579,-0.05349255,-0.005784343,-0.073804274,-0.06379601,-0.006800628,0.02529754,0.08860723,0.007713516,0.018023226,0.047379464,-0.021592395,0.018759971,-0.061724156,0.018257204,0.013388697,0.023026241,-0.024301382,-0.093944415,-0.012241394,0.01036439,-0.046893395,-0.043655116,-0.027334526,0.008116857,-0.022790678,-0.020856153,-0.08957093,0.0031403834,0.08238154,-0.059957247,-0.009549767,-0.013367515,0.01809442,-0.060186356,0.0740508,0.07234399,-3.951089e-08,0.036343955,-0.018454447,0.008895679,-0.02708945,0.024566267,0.07353218,-0.028318353,0.019017931,0.053107925,0.022815662,0.04761361,-0.0073608854,-0.0155851105,-0.054995306,0.026622891,0.08947251,-0.09617121,-0.0470287,0.053794846,-0.010623071,-0.028725907,0.07849438,-0.07533538,0.046194393,-0.057406798,-7.67808e-05,-0.0057662292,0.09112,0.0036758308,-0.05417161,0.015164775,-0.027774327,0.019267717,-0.1067165,-0.11213241,-0.04448023,0.054452915,-0.02030931,0.0805123,0.005428924,0.040175114,-0.06300077,-0.09592093,0.02893059,-0.025519485,-0.03459438,-0.015846392,0.033273943,-0.052667044,-0.061100267,0.06057687,-0.016911222,0.005358585,-0.034125898,-0.006179763,0.03732942,-0.044246368,-0.038233273,-0.094312824,-0.0059314854,0.025645355,0.004575978,0.14483172,-0.08937236 +2.1.1.228,"This enzyme is important for the maintenance of the correct reading frame during translation. Unlike TrmD from Escherichia coli, which recognizes the G36pG37 motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37 [4].",384,1.0,-0.035841424,-0.059650794,-0.08784868,-0.054749843,0.021941667,-0.02933427,-0.013574862,0.033659093,0.034257878,-0.03724808,0.03177886,0.027822038,-0.117401555,0.014302978,-0.023664415,0.021045504,-0.07827003,0.031489212,-0.008945762,-0.1322526,0.038986757,0.047087435,-0.03645241,-0.002326467,-0.021504726,0.0050776424,0.0104273455,0.0076179043,0.05403549,-0.04039875,-0.09312056,0.06757224,0.04932271,0.0044360845,-0.029212115,0.1832859,-0.095737696,-0.087281466,0.105569,-0.057944708,0.040125154,-0.02917794,0.012355657,0.03240694,-0.010210388,-0.060565703,0.013840576,0.0027669445,0.0037434592,0.058299467,-0.058482863,-0.020014971,0.020265995,0.05131803,-0.048263006,0.031665783,-0.08430838,-0.01428091,0.0064130207,-0.0035467679,0.0027872764,0.013264486,-0.044940222,0.013445163,0.06739477,-0.016048046,0.09688274,-0.017829256,0.014311392,-0.012686157,-0.027929135,-0.019316237,0.004669556,0.12992343,-0.026476795,0.033401046,0.012844391,-0.058357026,0.0706105,0.017714301,0.054344714,0.034541458,0.12067339,0.01920375,0.065331705,0.02279183,-0.027011873,0.12392047,0.032561127,0.058987267,0.029016385,-0.012363873,-0.01792367,-0.002518962,-0.038199596,0.057173546,0.007936404,0.028453272,0.049118146,-0.0071145636,0.06613699,0.085803725,-0.05484181,0.011391728,-0.02211632,-0.013824569,0.0698214,0.050781697,-0.038134173,-0.040055536,0.0007021037,0.035253596,0.048223894,0.016092287,0.002324953,0.025767576,-0.011768032,-0.046627276,0.025779763,-0.043089446,-0.06337436,0.011300452,-0.019075962,0.04149193,-0.060002387,0.01579504,-0.073003456,8.12744e-34,0.007536351,0.050161652,0.05164638,0.007932289,-0.022397544,0.031680983,-0.031732608,-0.04186606,-0.09181985,-0.010463025,-0.083538346,-0.11003982,0.010526636,0.009159835,-0.027713923,0.0023234293,-0.044755705,0.04837083,0.023205353,0.00057428953,-0.015213319,0.05860846,-0.07285111,-0.05748303,0.0098053515,0.10230983,-0.032973394,0.0047847535,0.05222234,-0.012337204,-0.06881798,-0.026120245,-0.07054758,0.0018987095,0.055218045,-0.06394885,-0.03563999,-0.022871668,-0.019380389,0.063861445,0.038938798,0.08318562,-0.014470768,-0.010798775,-0.026680682,0.036698837,-0.020494318,-0.0035981413,-0.0045092762,0.02277957,-0.012076468,0.037364163,0.0053129415,-0.13316184,-0.016543072,0.012695962,0.030810356,-0.015653146,0.007287648,0.06320837,0.030524528,-0.03364033,0.05335917,0.091533,0.01231161,-0.015540897,-0.13259132,-0.07049791,-0.03338177,0.102384716,-0.077530086,-0.09696396,0.07345091,-0.009596927,0.02434174,-0.02377351,-0.049141005,-0.06492394,-0.016676271,-0.010338605,-0.0041516176,-0.03399314,-0.0039641266,-0.013304244,-0.06763616,-0.0011522896,0.036940627,-0.10326177,-0.0024198052,0.06192737,0.055102047,-0.06826999,-0.06889099,0.040645123,-0.0011513795,-2.7133172e-33,0.005136846,-0.05116814,0.04818105,-0.08990153,-0.13837661,0.026782414,0.07825147,-0.06577053,0.04707964,0.0031020436,0.17579657,0.017940117,-0.06268245,0.005491807,0.03546491,0.0016032192,-0.016163187,-0.024185209,0.0061085564,0.0036991201,0.0034312576,0.043008666,-0.046998657,0.13111968,0.013116664,0.05835409,0.014195257,0.027571078,0.03882687,0.014424794,-0.053668935,-0.027281817,-0.013624804,0.022456774,0.016022827,0.014805029,0.011207716,-0.01009682,-0.014787919,0.014506396,0.0127597265,0.10194366,-0.005902075,0.074686304,-0.039939687,0.07665091,-0.021473741,-0.040402275,-0.033728667,-0.06621966,0.035250727,0.04766654,-0.036492057,-0.034921534,0.033992387,0.008641487,-0.023873532,-0.021026812,-0.027034417,-0.08524985,-0.044532537,-0.05334378,-0.017110623,-0.033950683,0.04007765,0.035543356,-0.006400528,0.037425715,0.014615964,-0.008720345,0.03107802,-0.025539303,-0.053945318,0.038168035,0.008213967,-0.086772606,-0.04434834,-0.07028718,-0.007717997,-0.034785863,-0.035153054,-0.016618809,-0.039036676,0.010197047,-0.016489787,-0.06569139,0.034100648,0.14604264,0.037478942,0.09775459,0.015598127,0.038662873,-0.09411505,0.028809246,-0.030686004,-3.4851112e-08,-0.021652987,-0.108169585,-0.028805053,-0.058383465,-0.07110094,0.062400457,-0.073684506,0.0015918635,0.051490482,0.03043435,-0.038080316,0.029565739,0.0031983526,0.04124266,0.010413017,0.039895013,-0.092199445,-0.005617189,-0.003067819,-0.04554445,-0.07667327,0.059101325,-0.077658765,0.032025974,0.043881718,0.015699325,-0.009836395,0.15584219,0.04663674,-0.037577514,0.007186871,0.010513206,0.033068154,0.021442853,-0.026547538,0.07319068,0.03590521,-0.047642328,-0.02340369,0.0337566,0.05159083,-0.04027703,-0.09090129,0.0406504,-0.03988192,-0.021152135,0.027853327,0.042814568,0.036467858,-0.0037746972,0.008083513,-0.030962434,-0.0047399537,0.03537476,0.009140522,-0.03543827,-0.046520736,-0.06679446,0.0026177953,-0.038298257,0.037790004,0.032570682,0.11885643,-0.12260658 +2.1.1.229,The enzyme catalyses the posttranslational modification of uridine residues at the wobble position 34 of the anticodon loop of tRNA. ,384,0.99999994,-0.015772695,-0.06366924,-0.08224858,-0.066809215,-0.06744759,-0.076898456,-0.019759543,0.028860925,0.0387909,0.03785999,0.076962814,0.00235372,-0.061911125,-0.00570222,-0.10441822,0.02449098,-0.08717145,0.056839567,0.09323546,-0.015014999,0.03852473,0.087850675,-0.016765295,0.03217215,0.011685766,0.058310054,0.019208733,-0.03878326,-0.0024261218,-0.08754756,-0.069446824,-0.04711702,0.06026052,-0.07313501,0.014075524,-0.022591908,-0.1373864,-0.0050543225,0.09535658,0.023336982,0.029950928,0.011862987,0.04851106,-0.07911106,-0.03198708,-0.007130738,-0.003985458,0.056485333,-0.032742314,0.1149551,-0.002035731,0.0004608248,-0.038136043,0.045406647,0.002428104,0.052961484,-0.055720925,0.017062847,0.032505393,0.02492156,0.09138777,0.07048845,-0.016459865,-0.04942144,0.015518327,-0.08667779,-0.0011467964,-0.01729736,0.045293536,-0.015087464,-0.018874979,0.0014050734,0.029097978,-0.052858293,0.030008368,-0.008657394,0.014802932,0.0007758547,-0.027254112,0.05541289,0.01566443,-0.014490366,0.060162216,0.038953222,0.05065468,0.04039827,0.01976536,0.012693433,0.051353313,0.042464,0.08608735,0.042482536,-0.019352801,0.00078138395,0.0037586268,0.037188776,0.04570051,0.09941974,-0.057988826,-0.022108857,0.0150752,0.015433449,-0.022718936,-0.04432862,-0.018747393,-0.022199607,0.044920154,0.055854846,0.03290437,-0.022829728,0.0021819444,0.03539363,0.122528866,0.04709456,-0.0828729,0.028161114,0.017949618,-0.010009158,-0.010411791,-0.030362373,0.0005855438,0.0029576798,-0.010930859,-0.016562454,-0.014419678,-0.019945867,-0.060070183,-5.3221274e-34,0.013303511,0.027447939,-0.018626945,-0.023247568,-0.003834959,-0.043440882,-0.072515726,-0.0117359795,-0.053074505,-0.08867469,-0.095168844,-0.06874679,0.0016561607,-0.023960073,-0.047093343,-0.082468405,-0.0036898786,0.0063004326,0.08117132,-0.040279906,0.05770741,0.04673147,-0.052350327,0.02207025,-0.0044463584,0.10315083,-0.06751675,0.000501086,0.01103496,0.029687237,0.015818277,-0.015334257,-0.062020894,0.0027047175,0.11790551,-0.042905696,0.013644537,-0.03958515,-0.08820807,0.020548342,0.011258855,-0.017254107,-0.040237494,0.002935554,0.0044976664,-0.08601975,0.028501283,0.14732186,-0.004966551,0.080500565,0.01236984,-0.027389081,0.0035638344,0.023650486,-0.103065446,-0.023845581,-0.015325561,-0.081892505,0.029632743,0.07774922,-0.027418219,0.049656693,0.012429425,0.058438156,-0.04207448,-0.029149937,-0.03815125,-0.048103347,0.042612344,0.044852175,-0.03478238,-0.029639743,0.04741539,0.004678098,-0.0056425775,-0.02504928,-0.07639633,0.001970173,0.02634623,-0.030131623,0.06659696,-0.03376782,-0.013976741,0.0035826054,-0.0066267764,-0.00054959644,-0.01461348,-0.03242355,0.0063080103,0.08242827,0.002144804,-0.05224327,-0.094538175,-0.027892312,0.068039924,-6.566204e-34,0.1049965,-0.14586432,0.07287355,0.0072422926,-0.108554736,0.050103586,0.017802274,-0.078331724,-0.005627764,-0.07932378,0.07024127,0.023587294,-0.06966974,-0.021061655,0.011232625,-0.020365622,0.0137784155,-0.0035606695,-0.00033225754,-0.046585124,0.017645488,-0.023576159,-0.0429121,0.008453993,0.04876228,0.013766267,0.072819546,-0.03744013,0.042173218,0.060296208,-0.02743146,-0.0017423304,0.018447632,0.025548387,-0.042877663,0.13572006,-0.014762172,0.0027065873,0.06576074,-0.044343546,0.038568888,-0.07515688,0.0012615708,0.028846743,0.027337797,0.03526264,-0.066416286,0.006620576,-0.05351607,-0.054868206,0.13728873,0.053067412,0.05454222,-0.03930939,0.068197586,0.0288488,-0.045022793,-0.06352491,-0.02150904,-0.02668842,-0.0048661944,0.015717123,-0.0157339,-0.042867817,0.06719327,-0.016364604,-0.0078795105,0.069257244,0.051427554,-0.1010057,0.009543024,-0.041871294,0.01872384,-0.0031232901,0.0061693,-0.07793607,-0.011666579,-0.019086117,0.053010676,-0.044719234,-0.07358351,-0.015722718,0.07754182,-0.058800347,0.029612314,-0.016641058,-0.018043844,0.14368336,-0.040996373,0.10244957,0.041914858,0.028053818,0.007360387,0.011792017,0.11321251,-2.5463255e-08,-0.018750478,-0.07655351,-0.011494371,-0.006412271,-0.009189807,0.15222244,-0.0045615425,0.040107485,0.009710217,-0.00020481317,0.02825969,0.016645862,0.009148653,0.041318275,0.02142282,0.04797066,-0.09014261,-0.015677312,-0.03630062,-0.008438023,-0.12615359,0.033754483,-0.10930552,-0.04517185,0.0016266588,-0.044656824,-0.011948831,0.04570053,-0.105407216,-0.027522907,0.058957405,-0.032390896,-0.022044472,-0.01093504,-0.029936496,0.037665132,0.064224735,-0.031081501,-0.04052533,0.041984238,-0.03937092,0.041193604,-0.086597644,-0.012991128,-0.08788431,0.024297463,-0.020123683,0.08877646,-0.038057543,0.04232744,0.0537444,0.07880837,0.017796595,-0.03320312,-0.039721753,0.056051563,0.049315665,-0.07356638,-0.06390292,0.08650807,0.02164791,-0.008930406,0.07606575,0.0023011141 +2.1.1.230,"The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton [2]. 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The enzyme from Gardenia can also form glucosyl esters with 4-coumarate, caffeate and ferulate [3]. 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+2.4.1.272,Part of the biosynthetic pathway for soyasaponins.,384,1.0,-0.07085528,-0.069523655,-0.083930425,-0.024081167,0.019664051,0.07885666,-0.12751658,0.02769941,0.04969354,0.0142335,0.06806161,-0.023017883,-0.06837607,-0.09335163,0.018853547,-0.019640436,-0.10221317,0.04701845,-0.015598885,-0.06801279,0.042011194,0.0430583,-0.016344344,-0.03844418,0.049460474,0.013766437,0.0074019833,-0.031087615,0.03931246,-0.015417459,-0.027065668,-0.06410157,0.011637694,-0.07128598,0.02687504,0.17014539,0.013072287,-0.07293625,0.11839645,-0.040852424,0.028496344,-0.043501485,0.025663652,-0.11270354,0.04035095,-0.042592596,-0.0137331085,-0.0038154344,0.09165159,-0.08372723,-0.049196724,-0.06543486,-0.049930222,0.012039693,0.045624524,0.010643517,0.066446856,0.0076473486,0.010769149,0.039807204,-0.023672849,-0.016637191,0.05663029,-0.014126054,-0.065034814,-0.05546058,-0.030440798,-0.049521413,0.014592529,0.0072060055,0.031704787,-0.07833547,0.041295968,0.08515724,-0.048599247,0.06386185,-0.010432101,0.031523883,0.0021324113,0.010582691,0.089052044,-0.016318053,0.038420137,0.066554524,-0.04731952,-0.057998113,-0.025341537,-0.018027086,0.022696057,0.069909684,0.01902856,-0.032458007,-0.0038937475,-0.013649891,-0.075446524,0.005997421,-0.0038687978,-0.061066505,0.039035473,-0.03220425,-0.0060912976,0.017843923,-0.060965013,-0.12823853,-0.03232652,0.07829026,-0.0064622494,0.04672102,0.013535829,0.033018347,0.005302184,0.024309793,0.0027968467,0.002690953,-0.09281396,0.013896494,0.0016153767,0.01891373,0.0010640904,0.05316471,0.007634277,0.025842011,0.11290745,0.053499043,-0.027697422,-0.053031716,-0.026163574,-2.8653709e-33,0.11586812,-0.054125987,-0.013192351,-0.03518779,0.054764997,-0.038585775,-0.09312751,-0.069108695,0.0465937,-0.042702574,-0.08250791,-0.06749316,-0.048299454,0.0373901,-0.05673083,-0.03632632,-0.04648909,-0.021992356,0.033624142,-0.021424465,-0.009956458,0.028323537,-0.034109358,0.0081832055,0.020671915,0.03701885,-0.01692932,0.0026927993,-0.018331878,0.0014775051,-0.035737295,-0.06148288,-0.104159094,0.031080853,0.07768601,0.011343406,0.021840686,-0.036042813,-0.07154931,0.06452162,-0.014336672,0.04714746,0.038369708,-0.04088504,0.061349634,0.040593844,0.021393456,0.070909105,0.03927739,0.08488538,-0.04488934,-0.0043047657,0.11115294,0.007872764,-0.0205649,-0.043536097,0.035160597,-0.030219728,-0.007922773,0.0410166,0.010367874,0.028828958,0.014617284,-0.0055243177,0.0066792825,0.08625907,-0.04437789,-0.017416622,0.017073683,0.032305248,-0.033525247,-0.06336697,0.04001331,0.032279678,0.028775187,-0.04536591,-0.052926384,0.050176725,-0.045305774,-0.023720741,0.020569358,0.016876535,-0.008447683,0.07586066,-0.00095871446,0.09897408,-0.036327492,-0.009392957,0.00055396935,-0.041768044,0.040417872,0.012143726,-0.050985288,0.005207046,-0.020453308,2.7874204e-34,0.034429345,-0.03949896,0.06538205,0.0043837256,-0.054837983,-0.032408744,-0.06208318,0.012489804,0.014732199,0.030405799,0.011707561,-0.043881148,-0.0351232,-0.018529747,-0.0398674,0.037443273,0.029764954,0.04189938,-0.08516718,-0.03902001,-0.03496706,0.01962075,0.029840283,0.03281251,0.08135188,-0.0035367217,0.028004985,0.0022732627,-0.047888394,0.045803733,-0.031335965,-0.024866028,-0.15840143,-0.032110292,0.016479319,0.008412977,-0.034382064,0.013922348,-0.00021713485,-0.005187049,0.079120114,0.0644175,0.009462789,0.048634976,-0.030512461,-0.013114703,-0.09315127,0.032448277,-0.022539238,-0.0077576623,-0.07384248,0.020782856,0.08100158,0.035260715,0.014995773,-0.046000056,0.0821954,0.053812653,0.06652996,0.044335302,0.03198099,-0.08603071,0.00794604,0.01557534,0.059795663,0.06426739,-0.014674034,0.028088644,0.041690122,0.004043266,0.02098543,-0.05034745,0.1009294,0.05909393,-0.016911812,-0.0070921825,-0.02095263,-0.12940401,-0.0052594994,0.021739729,0.027193483,-0.023436833,-0.07942241,-0.06372361,-0.038835544,0.030056825,0.017713724,0.06921836,0.012649758,0.044956286,0.019618893,0.009551216,-0.011846326,0.0246021,0.0073015178,-1.9053509e-08,-0.00481724,-0.027012588,0.018607294,0.00044583523,0.0244363,0.048959147,-0.08709949,0.022552164,0.07043337,-0.033801153,-0.03488367,0.09820283,0.0130958855,0.04604529,-0.048573054,0.0271845,0.02123617,0.09453636,-0.009900883,0.026026601,-0.07656296,-0.046599023,-0.15130946,-0.011310789,0.10571539,-0.08079632,-0.025860645,0.089668736,0.06369738,-0.018306857,0.0052569695,-0.023912732,0.0050829723,-0.08211984,-0.05726376,0.03370338,-0.085461535,-0.057745103,-0.035386402,-0.07410912,-0.02556237,-0.004229765,0.013738909,0.024092974,-0.006432939,0.041984577,0.0665811,0.14735396,-0.056589145,0.076577686,0.006824891,-0.10459446,0.061057508,-0.06974704,-0.065942414,-0.059589792,0.05903984,0.0031215313,0.018503996,0.019129857,-0.046901736,0.056309212,0.14718883,-0.059740044 +2.4.1.273,Part of the biosynthetic pathway for soyasaponins.,384,1.0,-0.07085528,-0.069523655,-0.083930425,-0.024081167,0.019664051,0.07885666,-0.12751658,0.02769941,0.04969354,0.0142335,0.06806161,-0.023017883,-0.06837607,-0.09335163,0.018853547,-0.019640436,-0.10221317,0.04701845,-0.015598885,-0.06801279,0.042011194,0.0430583,-0.016344344,-0.03844418,0.049460474,0.013766437,0.0074019833,-0.031087615,0.03931246,-0.015417459,-0.027065668,-0.06410157,0.011637694,-0.07128598,0.02687504,0.17014539,0.013072287,-0.07293625,0.11839645,-0.040852424,0.028496344,-0.043501485,0.025663652,-0.11270354,0.04035095,-0.042592596,-0.0137331085,-0.0038154344,0.09165159,-0.08372723,-0.049196724,-0.06543486,-0.049930222,0.012039693,0.045624524,0.010643517,0.066446856,0.0076473486,0.010769149,0.039807204,-0.023672849,-0.016637191,0.05663029,-0.014126054,-0.065034814,-0.05546058,-0.030440798,-0.049521413,0.014592529,0.0072060055,0.031704787,-0.07833547,0.041295968,0.08515724,-0.048599247,0.06386185,-0.010432101,0.031523883,0.0021324113,0.010582691,0.089052044,-0.016318053,0.038420137,0.066554524,-0.04731952,-0.057998113,-0.025341537,-0.018027086,0.022696057,0.069909684,0.01902856,-0.032458007,-0.0038937475,-0.013649891,-0.075446524,0.005997421,-0.0038687978,-0.061066505,0.039035473,-0.03220425,-0.0060912976,0.017843923,-0.060965013,-0.12823853,-0.03232652,0.07829026,-0.0064622494,0.04672102,0.013535829,0.033018347,0.005302184,0.024309793,0.0027968467,0.002690953,-0.09281396,0.013896494,0.0016153767,0.01891373,0.0010640904,0.05316471,0.007634277,0.025842011,0.11290745,0.053499043,-0.027697422,-0.053031716,-0.026163574,-2.8653709e-33,0.11586812,-0.054125987,-0.013192351,-0.03518779,0.054764997,-0.038585775,-0.09312751,-0.069108695,0.0465937,-0.042702574,-0.08250791,-0.06749316,-0.048299454,0.0373901,-0.05673083,-0.03632632,-0.04648909,-0.021992356,0.033624142,-0.021424465,-0.009956458,0.028323537,-0.034109358,0.0081832055,0.020671915,0.03701885,-0.01692932,0.0026927993,-0.018331878,0.0014775051,-0.035737295,-0.06148288,-0.104159094,0.031080853,0.07768601,0.011343406,0.021840686,-0.036042813,-0.07154931,0.06452162,-0.014336672,0.04714746,0.038369708,-0.04088504,0.061349634,0.040593844,0.021393456,0.070909105,0.03927739,0.08488538,-0.04488934,-0.0043047657,0.11115294,0.007872764,-0.0205649,-0.043536097,0.035160597,-0.030219728,-0.007922773,0.0410166,0.010367874,0.028828958,0.014617284,-0.0055243177,0.0066792825,0.08625907,-0.04437789,-0.017416622,0.017073683,0.032305248,-0.033525247,-0.06336697,0.04001331,0.032279678,0.028775187,-0.04536591,-0.052926384,0.050176725,-0.045305774,-0.023720741,0.020569358,0.016876535,-0.008447683,0.07586066,-0.00095871446,0.09897408,-0.036327492,-0.009392957,0.00055396935,-0.041768044,0.040417872,0.012143726,-0.050985288,0.005207046,-0.020453308,2.7874204e-34,0.034429345,-0.03949896,0.06538205,0.0043837256,-0.054837983,-0.032408744,-0.06208318,0.012489804,0.014732199,0.030405799,0.011707561,-0.043881148,-0.0351232,-0.018529747,-0.0398674,0.037443273,0.029764954,0.04189938,-0.08516718,-0.03902001,-0.03496706,0.01962075,0.029840283,0.03281251,0.08135188,-0.0035367217,0.028004985,0.0022732627,-0.047888394,0.045803733,-0.031335965,-0.024866028,-0.15840143,-0.032110292,0.016479319,0.008412977,-0.034382064,0.013922348,-0.00021713485,-0.005187049,0.079120114,0.0644175,0.009462789,0.048634976,-0.030512461,-0.013114703,-0.09315127,0.032448277,-0.022539238,-0.0077576623,-0.07384248,0.020782856,0.08100158,0.035260715,0.014995773,-0.046000056,0.0821954,0.053812653,0.06652996,0.044335302,0.03198099,-0.08603071,0.00794604,0.01557534,0.059795663,0.06426739,-0.014674034,0.028088644,0.041690122,0.004043266,0.02098543,-0.05034745,0.1009294,0.05909393,-0.016911812,-0.0070921825,-0.02095263,-0.12940401,-0.0052594994,0.021739729,0.027193483,-0.023436833,-0.07942241,-0.06372361,-0.038835544,0.030056825,0.017713724,0.06921836,0.012649758,0.044956286,0.019618893,0.009551216,-0.011846326,0.0246021,0.0073015178,-1.9053509e-08,-0.00481724,-0.027012588,0.018607294,0.00044583523,0.0244363,0.048959147,-0.08709949,0.022552164,0.07043337,-0.033801153,-0.03488367,0.09820283,0.0130958855,0.04604529,-0.048573054,0.0271845,0.02123617,0.09453636,-0.009900883,0.026026601,-0.07656296,-0.046599023,-0.15130946,-0.011310789,0.10571539,-0.08079632,-0.025860645,0.089668736,0.06369738,-0.018306857,0.0052569695,-0.023912732,0.0050829723,-0.08211984,-0.05726376,0.03370338,-0.085461535,-0.057745103,-0.035386402,-0.07410912,-0.02556237,-0.004229765,0.013738909,0.024092974,-0.006432939,0.041984577,0.0665811,0.14735396,-0.056589145,0.076577686,0.006824891,-0.10459446,0.061057508,-0.06974704,-0.065942414,-0.059589792,0.05903984,0.0031215313,0.018503996,0.019129857,-0.046901736,0.056309212,0.14718883,-0.059740044 +2.4.1.274,Involved in the synthesis of several different major classes of glycosphingolipids.,384,1.0,-0.06462757,-0.036703154,-0.09758589,-0.01337356,-0.10025532,-0.0262292,-0.05784112,-0.0091565605,-0.006342678,-0.016351651,0.025632385,0.015564111,-0.06324313,-0.087225415,-0.03461206,0.030142615,0.03162316,-0.019383244,-0.03595878,-0.008614797,0.08046757,-0.0024305219,0.0030578338,0.034301292,-0.00069747714,0.040239193,-0.01805183,-0.059780106,-0.023093008,-0.062196035,-0.008769937,-0.011863485,0.05339184,-0.029949896,0.0059947013,0.0066408315,-0.07589993,0.03769905,0.075709544,0.024273828,-0.012704183,-0.055294517,0.01971028,-0.047979206,-0.047685757,-0.0682617,-0.040808775,0.097513035,-0.004410863,0.034080703,-0.002367053,-0.079062976,-0.13586876,-0.027464833,0.026498454,0.0647266,-0.11097613,0.07622354,0.016763996,0.058330677,-0.02289211,0.08588195,0.035425957,0.012775321,-0.12210624,-0.041837316,0.08430218,-0.029294254,0.026590401,0.058753908,-0.0028860779,-0.007439782,0.0069726226,-0.05254624,0.0032165882,0.0973316,0.00888775,0.024763694,0.016765773,-0.07836135,0.037253637,0.0017813155,0.12867908,0.08878232,-0.003437762,0.01765419,0.00089538924,0.05992386,-0.0024299093,0.0069676004,0.08978529,-0.047448263,-0.012975856,-0.008789471,0.008004386,0.06728178,0.05196817,-0.03593794,0.031994265,-0.04545741,0.026941592,-0.027598841,0.074197665,-0.07950198,-0.0035726104,0.10120318,0.01974052,0.02100539,0.024076346,-0.0013415745,-0.021755693,0.026864022,-0.013436465,-0.035508305,-0.06053879,-0.01243991,-0.022154318,0.029142067,-0.013362961,0.012834374,-0.013002333,0.02793272,-0.008497994,-0.015876615,-0.07975262,0.073094934,0.0015905274,-2.4255084e-33,0.089757904,0.083912976,0.005328598,-0.028803952,-0.034229476,-0.023806922,-0.019579668,-0.04761086,-0.041421484,0.025454728,-0.024924517,-0.03222359,-0.032101035,0.15652877,0.06324384,0.107159026,0.016695883,-0.0076569137,0.047148813,-0.05901657,-0.029991966,0.06407453,-0.014641814,-0.11672639,0.0023272384,0.15016247,-0.06632511,0.03476472,-0.03681939,0.0014080397,0.005498357,-0.08149913,-0.04917037,0.059895758,0.032463,0.053952336,-0.04899077,-0.09356991,0.06301384,0.030833015,-0.03009926,-0.00063952734,-0.033306852,-0.018271644,0.024613427,0.06298037,-0.05424952,0.021217177,0.021508498,0.029882804,-0.024137914,-0.007378405,0.085048966,0.06505148,-0.041775305,0.021612119,0.03532052,0.005262696,0.015085593,-0.0123754805,-0.03175442,0.09330432,0.009713742,-0.0694702,0.037427764,0.030153027,-0.09276428,0.022381961,-0.08506573,-0.033887852,0.10281923,-0.07563603,0.029210629,-0.0019229859,0.03597104,-0.0155256195,0.05328101,-0.0073889703,-0.016784526,0.025758496,-0.005710399,0.028224804,-0.033917796,-0.06223159,-0.038579963,0.08462488,-0.012661122,-0.04924864,0.051566478,0.07239285,-0.057791334,-0.02378609,-0.035250347,0.016997816,-0.032802034,-8.433201e-34,0.016520893,0.007966757,0.032038555,-0.011571784,-0.08681978,0.032887213,-0.053030554,-0.04597093,-0.0017934097,0.021796973,-0.03747834,0.035950415,-0.02341125,-0.091782026,-0.046810336,-0.07014153,-0.0270844,0.07351021,0.008099101,-0.038244773,0.007148772,0.042842172,-0.019937772,0.043351132,0.056526486,-0.050169565,0.00057682715,-0.01750759,-0.012344037,0.08746267,0.027321689,-0.02197024,-0.03779524,-0.058723006,0.05530631,0.0123152975,-0.07299332,0.034388658,0.014410477,-0.021997917,-0.06522859,0.02066608,0.11405304,0.008280409,0.1289936,0.07074923,-0.010501673,-0.00980513,-0.063790575,-0.037138492,-0.011288682,0.018648162,0.006278439,0.064522594,0.06181495,0.027667886,0.026028147,0.004064428,0.04589337,-0.10994547,-0.08575931,-0.06113412,0.012885106,-0.043468293,0.057615593,0.13780363,-0.013374337,0.010031649,0.04089719,0.025432728,0.00888183,-0.042477176,0.0076412978,0.045310233,0.034186825,0.0075259525,-0.046132755,-0.06645526,-0.030772386,-0.033984188,0.10296318,0.021704385,0.052956462,-0.036909424,-0.050265994,-0.02309375,0.044030193,0.073617466,-0.018785438,0.07747399,0.0238069,0.03068491,-0.022864077,0.08525094,0.040715616,-2.1074653e-08,0.075342566,0.04578586,0.053467132,-0.0693002,-0.019962221,0.010215632,-0.032499395,0.00050435186,0.031541944,-0.016532227,-0.08207466,0.018008778,0.08072343,-0.022848055,-0.05043869,0.039810818,-0.010596728,-0.006705317,-0.007851061,5.5490986e-05,-0.067133926,-0.0006463587,-0.04622563,0.030115671,0.042944103,-0.08563019,0.059147883,-0.0334565,-0.014176589,0.063573726,-0.033109065,0.036594976,-0.059297904,0.026376266,-0.005987086,-0.06128829,-0.0015508478,-0.043308854,0.015122968,-0.07965776,-0.06661328,-0.02229533,0.021246558,0.0011490189,0.018995367,-0.041692395,0.038543757,0.009843297,-0.083897516,0.06520045,-0.09972368,-0.03497151,0.012892128,-0.10516787,-0.12578,-0.06937929,-0.020038633,0.05547233,-0.043000463,-0.08536123,-0.0734687,0.024166668,0.10836788,-0.025188573 +2.8.1.9,"Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC 2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.",384,0.99999994,-0.07806445,-0.04019895,-0.10657564,-0.058753293,0.074687585,-0.055202737,-0.06498253,-0.02631715,0.07045628,-0.03401671,0.045080636,0.028350933,-0.049141064,0.025770683,-0.061946873,0.054905403,-0.02261964,0.06048731,0.040526956,0.008950054,0.085738696,0.019756943,0.0274148,0.0070577166,-0.024129212,0.051420067,-0.0029357977,0.05954131,-0.022487305,-0.079838805,-0.018234754,0.022862012,-0.0048334226,-0.06525268,0.034727693,0.0749617,-0.01022888,-0.011826508,0.017597366,-0.0787172,0.024771916,0.004704302,0.045287535,-0.04075502,-0.02496797,-0.006209916,0.026669957,0.024475338,0.017572807,-0.07530692,0.011195722,-0.060686655,-0.09884391,0.046092283,0.012365956,0.025202438,-0.06655576,0.038211696,0.06527323,-0.073996365,-0.051924672,0.07267681,0.023029229,0.048356775,0.020722939,-0.07305378,0.015885675,-0.04171636,-0.028015476,-0.058046155,-0.07685474,-0.013609295,0.07840051,0.03220294,-0.08089054,0.13426954,-0.008241158,-0.01840227,0.011840301,0.005296938,0.019724963,0.036536373,0.040373813,0.044443604,0.045986164,-0.056532633,-0.0047013345,-0.0048594098,0.02877973,-0.032706663,0.0652678,-0.028938195,-0.033214692,0.012296594,-0.1126267,0.023119492,0.08345043,0.115320496,-0.015311097,-0.036719088,-0.0014987137,0.011239727,-0.008399605,-0.08533619,-0.02280057,0.022412136,-0.023139881,0.10039904,0.03189303,0.029717427,-0.09355418,0.06066519,0.010619166,-0.027325148,0.009149215,-0.008067487,0.05053362,0.0151396785,-0.1110602,-0.00639963,-0.048654094,0.00042246847,-0.035622127,0.0133886915,-0.04873842,0.031990916,-0.10218385,4.948877e-33,0.13113768,0.034619052,0.082412235,0.02515718,-0.0078148525,-0.036427647,-0.016136624,-0.015631227,-0.035377674,-0.06444287,-0.05820898,-0.07349085,0.021210428,0.026770648,-0.033373263,-0.0071992814,-0.028473105,-0.068178765,0.07114034,0.030834887,0.0039059734,0.03174981,-0.02077096,-0.016235404,0.020585025,0.10511418,0.01570517,-0.018174386,-0.004720235,0.024055252,0.060232222,-0.114527114,-0.09158172,0.005679379,0.06817803,-0.020310316,-0.015461293,-0.055577856,-0.0048635723,-0.019616656,-0.09583964,-0.0579846,-0.069522165,-0.02356797,0.04390123,-0.066192515,-0.0061331377,0.13831306,0.051895916,0.031477254,-0.0126286335,-0.074639454,-0.0026544617,-0.009216167,-0.06621716,0.003600928,-0.0033999986,-0.063331015,0.0052412595,0.090237565,0.041844007,0.056552965,-0.049263082,0.01911093,0.0148875555,-0.012816737,-0.06755539,-0.058399003,-0.016653169,0.045267228,-0.040972415,0.0049338983,0.049111784,0.063563175,-0.013404665,-0.03389961,0.056589957,-0.08993265,0.06402159,0.05525623,0.0006590912,-0.0320331,0.019326735,-0.051637765,-0.013579495,-0.008189373,-0.073524006,-0.042850368,-0.021368206,0.078609884,-0.013361381,-0.074197486,-0.06338334,0.016016422,-0.028690523,-6.549515e-33,0.12401181,-0.06159241,0.1252308,-0.11039852,-0.08740423,0.03246636,-0.023154197,-0.02787863,0.04121203,-0.024287993,-0.039845373,-0.015463647,0.06401735,-0.052721173,0.0015637494,-0.0013660373,-0.010265537,0.069981925,0.008879869,0.00044531203,0.046226803,0.06594346,-0.022517677,-0.01244815,-0.0012934952,0.015908647,0.030887848,0.045379348,0.0108436905,0.05914873,-0.01604244,-0.00023414781,-0.087045446,-0.060835492,-0.073765725,0.016624277,-0.07902391,0.0067259544,0.020208232,0.009655021,0.0021279294,0.019096604,0.01998875,0.026933288,0.026750175,0.00676192,-0.0796943,0.05178511,0.09081313,-0.01666099,0.04136268,0.011582057,0.017100155,0.044478253,0.071007475,0.019253867,-0.021849958,-0.029952675,-0.014714452,-0.04490584,-0.03918259,-0.06023053,-0.0062546027,0.00176275,0.023938514,0.14163516,0.03643133,-0.0056717624,0.0441213,0.011879612,0.013285844,-0.013007782,-0.06996283,-0.034263227,0.0054691057,-0.019438308,-0.10355978,0.03123169,-0.019731114,0.017771972,0.008597724,0.012931392,0.040671322,-0.12596013,0.06526408,-0.011156011,0.013681968,0.09763523,0.02215117,-0.038802482,-0.010651233,0.019016331,-0.009604115,0.008954443,0.0642442,-4.1931575e-08,-0.0523565,-0.054091766,0.056916922,-0.020402627,-0.013671641,0.102885,0.04282539,-0.0019650199,0.026310025,0.006567915,0.06896994,0.10114572,0.059686255,-0.07105071,0.055174444,0.09820735,0.0040144986,0.0132434955,0.015823822,0.004446471,0.002065733,-0.0436908,-0.06271851,0.12508713,0.05743674,-0.051159583,0.042279564,0.012837811,-0.07740285,0.017740486,0.030184636,-0.020474577,-0.023488635,-0.098013945,0.0065331883,0.013602049,0.004472309,-0.045734078,-0.009711941,-0.02249018,-0.017979374,0.043631826,-0.017347636,0.026961712,0.04024478,0.03218024,-0.049619105,0.06344677,-0.07387089,0.032017235,0.08696598,-0.041596863,-0.034616888,-0.08871735,-0.13786024,0.033880856,0.050245192,-0.07185187,-0.027520245,-0.002520838,0.01217037,-0.03372848,0.11626431,-0.03196383 +3.2.1.176,"Some exocellulases, most of which belong to the glycoside hydrolase family 48 (GH48, formerly known as cellulase family L), act at the reducing ends of cellulose and similar substrates. The CelS enzyme from Clostridium thermocellum is the most abundant subunit of the cellulosome formed by the organism. It liberates cellobiose units from the reducing end by hydrolysis of the glycosidic bond, employing an inverting reaction mechanism [2]. Different from EC 3.2.1.91, which attacks cellulose from the non-reducing end.",384,1.0,-0.034628063,-0.057088457,-0.0702672,0.0072763944,-0.0073687704,-0.06063381,-0.028171381,0.042458303,0.08119912,-0.010372115,0.06647947,-0.016029118,-0.0261555,0.056771517,-0.07088709,-0.06349582,0.0031137033,-0.0057087815,-0.079881385,0.0034167864,0.09949784,0.028437499,-0.002392613,-0.0010934247,0.07112449,-0.039059144,-0.017229576,-0.0074877366,-0.036604464,-0.083294936,0.023250286,0.0013518902,0.05405714,0.02096582,0.10309964,0.0720889,-0.002059324,-0.050215144,0.07780417,-0.029902251,0.0002767769,-0.044825293,0.0563888,-0.050734296,-0.13644055,0.05100764,0.008696782,-0.041344237,-0.0050984826,0.007858483,-0.0019061633,-0.05246726,-0.009727269,0.016635742,0.0462359,-0.007685232,-0.033051178,0.033361867,0.05102909,0.03215303,-0.015676899,0.031981573,-0.049907863,0.06481032,-0.071171306,-0.09167236,0.068795115,-0.056971528,-0.08956507,0.0037275867,-0.008057866,-0.0076984726,0.04466554,0.007911174,0.038292952,0.07466598,-0.033814177,-0.079860784,0.024376059,-0.0049467892,0.047560945,0.03741779,0.05399163,0.06818117,-0.019725213,-0.024533633,0.088738546,0.03748002,0.035831682,-0.04343586,0.06401884,-0.0059607457,-0.04054877,0.023659699,-0.03029359,0.051638134,0.058337543,0.021668743,-0.03575033,-0.09317291,0.01220812,0.008795633,0.07081277,-0.055101156,-0.030323613,0.00622208,0.066059805,0.11826093,0.040722143,-0.07991342,-0.031700183,0.015362476,-0.025353665,-0.037654318,-0.016344555,-0.03163962,0.085656956,-0.03534068,-0.038940627,-0.057866633,0.011966298,0.0114330435,0.03985308,0.069527745,-0.07609945,0.09193615,-0.05373024,2.1441704e-33,-0.026764615,0.031719584,-0.002975101,-0.052602563,0.036691297,-0.050108816,-0.08384423,0.0205126,-0.036738463,-0.034636922,0.004374539,-0.01563013,0.00635328,0.07774406,-0.018165104,-0.0100283,-0.047673155,-0.038980395,0.036329173,0.02118368,0.026745955,0.058127504,0.03138648,0.011902674,0.026037749,0.044966828,0.00022309813,-0.030018441,0.033017084,-0.0049103363,0.0644812,-0.040985625,-0.087354325,0.0062636416,0.03299446,0.10423729,-0.0395439,0.004917466,0.009499993,-0.0036262192,0.00724919,0.047009,0.003881987,-0.041103434,0.019754762,-0.03853026,-0.03750255,0.059346825,0.008542029,0.04943084,0.10680635,0.014342417,0.03677124,-0.03889919,-0.034863304,0.07453075,-0.0031534755,0.03931313,-0.007980727,0.06676529,-0.013990103,0.08232,-0.08653163,-0.007952342,0.0011891072,0.011850798,-0.06067113,-0.027198995,-0.063010275,0.018905954,-0.0841589,-0.021801492,0.0920387,0.0347349,0.02185722,-0.011574026,-0.026095837,-0.047057305,-0.010465271,-0.01988236,0.0059753493,-0.009805896,0.0067396224,-0.030362736,-0.046027247,-0.036356304,-0.060800534,0.0170432,-0.068728074,0.09307643,0.019151006,-0.14341907,-0.020754429,0.086121805,-0.057688236,-4.0662263e-33,0.15646107,-0.08608398,0.093889706,-0.06129123,0.0073214686,-0.0048330994,0.048501287,-0.006233801,-0.03507992,-0.008308347,0.07729761,0.06939799,0.0386254,0.01177167,0.02479886,0.010191013,-0.06272056,0.05332524,-0.01391729,-0.060846537,0.0038767275,0.108430855,0.03335548,0.030850269,0.06819666,0.028605616,-0.036893297,0.083284825,0.009976654,-0.047427177,-0.0489151,-0.00066112017,0.0065126973,-0.06094076,-0.037615545,0.043677915,-0.082079284,-0.0048291134,0.07871421,-0.023269126,-0.009419195,0.04018752,0.0030015795,0.023126112,0.03807446,0.061609596,-0.008831997,0.028523646,0.018702466,0.058590397,-0.052996367,0.02449858,-0.06144114,0.028668648,0.06536935,0.006909576,0.02071171,-0.0065696845,-0.07242747,-0.0932716,-0.08224637,0.03447933,0.06496465,0.024225771,0.09169813,0.05379162,-0.08366786,0.050729975,0.033604573,-0.01695098,0.057979852,-0.02595399,-0.07842264,-0.07557454,-0.00073979335,0.009472341,-0.12645765,-0.028391236,-0.026295584,-0.0031235209,0.040400967,0.040627025,0.040361363,-0.062270783,0.08991213,-0.07776734,0.03974506,0.060771964,-0.012434376,0.0048536537,-9.538661e-05,-0.045450106,0.047253158,0.06995439,0.07367478,-3.8842103e-08,-0.035205282,-0.004992268,0.054122277,-0.12589388,-0.0047956505,-0.021752028,-0.015838124,0.053208183,0.027648732,-0.072764665,0.020583602,0.07423235,0.0112733245,0.050500695,-0.03274161,0.018964998,-0.09249132,-0.09387509,0.011146631,-0.021674784,-0.099368505,-0.07834747,-0.05219752,0.13387173,-0.08955549,-0.04469071,0.0391426,0.025406776,-0.03786044,-0.019623505,0.0010916205,0.035485055,-0.05482651,-0.0277479,-0.045580763,0.013491474,-0.0673302,-0.035796985,-0.05541053,0.050515942,0.053571943,-0.080309354,-0.018955814,0.003989134,-0.0072411993,-0.0116459085,-0.032687493,-0.00021453454,-0.0008030765,0.03908675,0.002740203,-0.016390555,-0.112180434,-0.0051258104,-0.0779905,-0.036892164,-0.027364142,0.05303089,0.013393518,-0.020436116,-0.028853662,0.003913919,0.16788769,-0.0022781251 +3.2.1.177,"The enzyme catalyses hydrolysis of a terminal, unsubstituted xyloside at the extreme reducing end of a xylogluco-oligosaccharide. Representative alpha-xylosidases from glycoside hydrolase family 31 utilize a two-step (double-displacement) mechanism involving a covalent glycosyl-enzyme intermediate, and retain the anomeric configuration of the product.",384,1.0,0.036459807,-0.07210018,-0.0606236,-0.024950862,0.0224217,-0.03106329,-0.057437375,-0.00233663,0.011018933,0.01613341,0.06901373,0.051709227,-0.086434565,0.0512999,-0.017981851,0.027678672,-0.021256376,0.010568615,-0.0048528705,-0.035322383,0.109483264,-0.042626187,0.028408663,0.06274074,0.0692691,-0.016376473,0.009128532,-0.08445272,-0.016211439,-0.055005584,-0.016412655,-0.08449116,0.060152978,-0.040753003,0.039679993,0.043154664,-0.054044057,-0.055292513,0.05090492,-0.031537265,-0.005133478,-0.04100867,0.008633382,-0.059661016,-0.11427841,-0.06554606,-0.023320492,0.024128586,-0.00092587067,0.06996041,0.021383869,-0.09077685,-0.09375166,-0.008141579,0.058345072,0.044509027,-0.09529809,-0.011859182,0.008288332,0.099183775,0.084294096,0.08084535,-0.049531177,0.06774225,-0.10434184,-0.101940945,0.08982824,-0.006236839,-0.032600924,0.0153609365,-0.0326776,-0.018504022,-0.0015101855,-0.043285586,0.0610726,-0.03607464,0.00093387696,-0.008107591,0.081870995,0.021414086,0.042535827,0.021766009,0.087499775,0.072214864,-0.010825958,-0.050107483,-0.0101227965,0.017233316,0.05713513,0.010268382,0.031951524,-0.039397467,0.029709937,-0.0013315107,0.05461654,-0.03509762,0.10954875,-0.010984072,-0.005881022,-0.036616933,0.010390025,0.023838585,0.035844065,-0.08044929,-0.03741062,0.055928744,-0.028249117,0.0593888,0.0486327,0.07847591,-0.0040861797,-0.017342206,0.021227883,-0.045710742,-0.06727516,0.042635147,-0.015175738,-0.009305558,-0.05082146,-0.051517446,0.03212586,-0.060865484,0.047094934,0.04966123,-0.037220616,0.081164286,0.013084275,2.1644574e-33,0.048841905,0.06822149,-0.028441343,-0.037273273,0.018142244,-0.015858939,-0.0012769375,0.059559625,-0.09178895,0.08056651,-0.038361985,-0.017260348,-0.0056387344,0.05245985,-0.031402517,-0.03168137,0.02103894,0.017154697,0.01942208,0.10893895,-0.01165628,0.070255175,0.006180476,-0.043162487,0.0329815,0.0036621268,-0.084947936,0.023386877,-0.0036422736,0.0021854753,-0.035939455,-0.03246539,-0.14886256,0.049585454,0.05932975,-0.006899773,-0.043269765,-0.07657989,0.061783258,0.03465738,-0.059586663,0.045675028,0.026939398,-0.090745434,0.034377065,0.014195553,-0.0008374427,-0.0075549893,-0.029554956,0.034331083,-0.0142053375,0.025341,0.033015043,0.10009714,-0.0054267896,-0.007473442,-0.010526377,-0.016537175,-0.005621185,0.053298943,0.009192263,0.055168405,0.019860448,-0.02332063,-0.021045495,-0.021369314,-0.040162627,-0.020383842,-0.021555088,0.06434332,-0.0642191,-0.08764787,0.033515777,-0.041358057,0.014257218,-0.07684752,0.01320277,0.006363824,0.028864035,-0.018294705,0.05103012,0.044077978,0.060441926,0.014097827,-0.05809696,0.035695046,-0.048104048,0.004058032,-0.025663672,0.067417,-0.07512131,-0.06794757,0.004893676,0.08188457,0.044283964,-3.1243935e-33,0.12442241,-0.09502,0.024700385,-0.082585156,-0.07490731,-0.013640975,0.085800804,-0.059518494,0.009536097,-0.0115917055,0.027335709,0.03345742,-0.052851703,0.020253066,0.010393879,0.007838074,0.0078382585,0.08591912,-0.045308996,-0.024190284,0.0106297955,0.093494356,0.007003475,-0.04418704,0.09352658,-0.04884043,0.035126235,0.010780191,0.04478971,-0.034044288,-0.043410428,-0.07362156,-0.007576555,-0.059203144,-0.02931264,0.04658476,-0.08979037,0.038334627,0.012106033,0.008660575,0.05954847,0.06754576,0.03486775,0.08412797,0.06064731,0.038503077,-0.11541389,0.035313286,-0.023000015,-0.04107462,-0.029640866,-0.009156682,0.00040316887,0.09490318,-0.0012747612,0.04407941,0.04285422,0.0080670705,-0.023095025,-0.04399731,-0.07358751,0.0038818577,0.05554772,-0.023406254,0.07046468,0.007683542,-0.042261057,0.019327682,0.01056028,-0.0068849446,-0.0044411286,-0.070180304,-0.0900835,0.056005213,0.022786545,-0.009651317,-0.086720705,-0.1025979,0.021553967,-0.043454718,0.072708376,-0.011137754,0.062317125,-0.059664845,0.048814204,-0.058097187,0.042948715,0.1117133,0.0219522,0.091780126,0.07144571,-0.02300642,0.016970921,0.05854731,0.109747425,-3.36707e-08,-0.04223126,-0.051259637,-0.007997528,-0.043612756,-0.033912044,-0.0005116913,0.027404971,-0.0042554257,0.017947882,-0.038774014,-0.018298099,0.07211846,0.043770283,0.06503923,-0.029887268,0.044674765,-0.010597892,0.0075305197,-0.03923448,0.020809794,-0.10142296,-0.019588504,-0.087762006,0.009072032,-0.05811967,-0.1083586,0.04124823,0.07624784,-0.045490958,0.011460675,-0.079425566,0.04455648,-0.0042082816,-0.03260862,0.05042891,0.04588596,0.0055730925,-0.014772381,0.000112972324,-0.072771154,-0.043136463,-0.082113534,0.004252282,0.006346655,0.026582107,0.007565798,0.009158915,-0.0039106775,0.020653708,0.099829115,0.0221538,-0.0060351943,-0.01147074,-0.079033084,-0.030799264,-0.058352746,-0.034274038,-0.0043818406,-0.003479644,-0.075064346,0.035040405,-0.044223733,0.16505016,-0.087421104 +3.2.1.178,"The backbone of porphyran consists largely (~70%) of (1->3)-linked beta-D-galactopyranose followed by (1->4)-linked alpha-L-galactopyranose-6-sulfate [the other 30% are mostly agarobiose repeating units of (1->3)-linked beta-D-galactopyranose followed by (1->4)-linked 3,6-anhydro-alpha-L-galactopyranose] [2]. This enzyme cleaves the (1->4) linkages between beta-D-galactopyranose and alpha-L-galactopyranose-6-sulfate, forming mostly the disaccharide alpha-L-galactopyranose-6-sulfate-(1->3)-beta-D-galactose, although some longer oligosaccharides of even number of residues are also observed. Since the enzyme is inactive on the non-sulfated agarose portion of the porphyran backbone, some agarose fragments are also included in the products [1]. Methylation of the D-galactose prevents the enzyme from Zobellia galactanivorans, but not that from Wenyingzhuangia fucanilytica, from binding at subsite -1 [2,3].",384,1.0,-0.043829124,-0.12052235,-0.040388327,-0.029408898,0.0398918,0.018659584,0.0040085013,0.0114884,0.09833289,0.0050242245,0.014777187,0.059695832,-0.1099035,0.048877455,-0.045959752,0.021226805,-0.03438338,0.027009862,-0.055156365,0.059748452,0.13029836,-0.058897622,-0.06633588,0.014512449,0.11806028,-0.042985886,0.01717703,-0.046833258,-0.06895315,-0.061062917,-0.05827492,-0.08743642,0.049909625,-0.010225977,0.04630277,0.048187796,-0.0013757568,-0.049879458,0.022616707,-0.046044707,0.031498846,0.05642036,0.0031329286,-0.036908116,-0.054258432,-0.020608015,-0.06336216,0.047085818,0.01424306,-0.027139489,-0.028538551,-0.12232508,-0.048041124,0.004389051,0.024344599,0.020527614,0.00062255963,-0.06801679,-0.0069204774,0.027299786,0.059621133,0.025797471,-0.047356922,-0.0007023617,-0.04772411,-0.086448714,0.08659044,-0.019754538,-0.029420571,0.018733524,-0.071520425,-0.0017486569,-0.041174293,0.034775645,0.055343505,0.065281436,-0.031978056,-0.038270872,0.052135456,-0.019000756,0.06914165,0.10488214,0.0053895907,0.02461589,-0.027083343,-0.025900938,0.0105785765,0.112531446,0.064408846,-0.0077009113,0.015324191,-0.0047426447,-0.02736523,-0.059062026,0.027223945,0.03650959,0.062965125,0.03356717,0.057696134,-0.030790951,0.020652393,-0.036436815,0.04520186,-0.05612001,-0.053147245,0.04572169,-0.024797795,0.10065389,0.034757737,0.0035470468,0.0021654672,-0.0025387725,0.053772252,0.019625966,-0.10610516,0.059766788,0.01639264,-0.062482174,-0.024116144,0.02269439,0.04142284,-0.024968604,0.08890644,0.065401144,0.006613339,0.0939679,-0.0824063,1.9091432e-33,0.10720434,0.054890003,0.06279472,-0.03206321,0.024584912,-0.007962402,-0.0758153,0.03304815,-0.062316693,0.09851445,-0.12805879,0.009783963,0.022415342,-0.02356302,-0.028936107,0.09272658,0.033396285,0.027353242,-0.019788582,0.02961573,-0.0018785144,0.06722055,-0.05108177,-0.0009140694,0.06627555,0.00862286,-0.03606561,-0.0019800898,0.04510794,0.00463934,0.04514154,-0.044598117,-0.08358179,0.048208054,0.099255964,-0.045123518,-0.07319479,-0.06419967,-0.01604347,-0.027858583,0.060616024,0.018712118,-0.016346153,0.029191041,0.041332245,-0.066066034,-0.025590366,0.04022807,0.0060313796,0.07557905,0.021656787,0.0075728954,0.05150121,0.048688937,-0.075435646,0.031390745,-0.0659321,-0.01440889,0.04921468,0.06987671,0.006356584,0.0368054,0.013680042,-0.029080711,-0.0035820217,0.02540565,-0.05177562,0.049786672,-0.02495988,0.05553815,-0.042770296,-0.081586964,-0.036901772,0.04718225,0.03306571,-0.051014714,0.028512318,-0.0060164095,-0.014458973,-0.045895986,-0.015173777,0.038191773,0.018382432,-0.016093014,-0.11122817,0.009965118,-0.026820425,-0.006958672,-0.011449249,0.067487106,-0.011169204,-0.029018296,-0.10271008,0.022969022,-0.02449214,-2.9389464e-33,0.111345775,-0.109076194,0.07117265,-0.11274431,-0.031183623,0.05574639,0.024473976,-0.030000709,0.0140003245,-0.09229241,0.034812357,0.024198493,-0.040245008,-0.047131155,-0.0059537156,0.020176508,-0.009401253,0.079396866,-0.021922728,0.035752743,-0.020632692,0.06316086,0.04184605,-0.0130391,0.04449495,-0.048785176,0.038654394,0.051627085,0.059212156,0.09075686,0.07804512,0.011220858,-0.0116814,-0.06025141,-0.08148865,-0.0028693536,-0.028152289,-0.0359948,0.031758744,0.075411215,0.002495899,0.019580027,0.042158905,0.0380522,0.08610846,0.04872242,-0.07015424,0.01104377,0.0027518135,-0.045748282,0.01485247,-0.08870339,0.027357096,0.04852463,0.007863708,0.045328524,0.012241342,0.05491029,-0.044267785,-0.043478046,0.0037838384,-0.05458009,0.018643167,-0.059267335,0.061880566,0.016139861,-0.0015470522,0.036318436,0.0009892132,-0.0060494007,-0.030056894,-0.025522634,-0.07749918,0.009703258,0.0061341044,0.021600679,-0.09926317,-0.0539353,0.03299856,-0.012705902,-0.022079058,0.0792655,-0.009993229,-0.06504158,0.006108631,-0.017181953,0.06330063,0.16295846,-0.016473282,0.019237587,-0.050566614,0.01077562,-0.004236191,0.04656728,0.07341116,-4.685479e-08,0.081036426,0.029221177,-0.0030147913,-0.050959934,-0.06471384,0.0042263158,0.0333667,0.03137673,0.001965007,0.004386297,-0.024758408,0.10578448,-0.014626216,-0.032623556,0.007844176,-0.008628492,-0.041442435,-0.0071885767,-0.05149055,0.026274184,-0.046686318,0.03641231,-0.13544549,0.02164805,-0.018726332,-0.07135129,0.028593866,0.053022593,-0.032154456,-0.0018763614,0.036421303,0.0038025205,-0.039266128,-0.10127366,-0.052357417,0.050284695,-0.07266822,-0.056525793,0.05989663,-0.013495358,0.051101983,-0.08013324,-0.01369931,0.004795067,-0.050935917,0.01596382,-0.0301224,0.038598057,-0.044076607,0.07874258,0.050251897,-0.020909902,-0.11071783,-0.0776643,-0.050332524,-0.059470877,0.053507905,-0.04144846,-0.006731164,-0.030727977,0.031160688,-0.068660334,0.10723754,-0.011186511 +3.4.11.26,"Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed.",384,0.99999994,-0.048769474,0.02619257,0.025482675,-0.04234457,0.09835495,0.005672825,-0.019622348,0.022666244,0.0071502244,0.005337334,0.04839122,0.07826919,-0.03423516,0.023653945,-0.057401657,0.013946931,-0.061797734,0.008901278,-0.057972293,-0.039463263,0.020647332,-0.03069193,-0.0783373,0.002185498,0.012846528,0.06826568,0.08211512,0.0027647656,-0.039320625,-0.0015948055,-0.009521614,-0.04565732,-0.03319328,-0.07236782,0.029826699,0.10491382,-0.0779516,-0.025445003,-0.001441781,-0.05385235,0.08163659,0.023505036,-0.050717875,-0.017592832,0.07344316,0.04798517,-0.064701565,0.092026435,0.0069811796,-0.05009091,-0.038966913,0.0095086945,-0.028159797,0.10090116,-0.04516425,0.032067325,-0.09445044,-0.08341154,-0.02858904,0.023643544,-0.048758823,0.012753853,0.015192883,-0.029006392,0.10172826,-0.0016938413,0.06714446,-0.10547758,0.043907635,-0.010713956,-0.07197868,-0.061818812,0.0056770076,0.06890659,0.046958257,-0.0147445975,-0.040751014,-0.08205919,0.05508342,-0.019820504,0.004849606,0.03534247,0.03298607,0.09194083,0.01715763,0.019168526,-0.025222216,0.004218524,-0.0012336307,-0.012573159,0.08013901,0.009055658,0.019584553,-0.0020719427,-0.11026698,-0.036485422,0.014169299,0.07407037,-0.07933825,0.052577544,0.013305582,0.04675541,-0.042875253,-0.09336429,-0.100267686,0.007210514,0.017072132,0.049296174,-0.021150097,-0.03187131,-0.03166464,-0.0052423575,-0.004433732,0.010085748,0.05148453,0.13932833,0.06783684,-0.012432168,-0.010054498,0.02079803,-0.050910298,-0.065305054,0.06325846,0.072946414,-0.043392785,0.067396626,-0.08412478,1.404529e-33,0.007966422,-0.035305817,0.03606422,-0.0391973,0.012873556,-0.038756408,-0.03726139,-0.006341149,0.024812704,-0.045788396,-0.028048107,-0.07540747,0.00673892,-0.033613574,-0.030989027,-0.02723387,-0.00495241,0.052336086,0.06847037,-0.0028439534,0.021901863,0.050795346,0.026267773,-0.053664785,0.07628991,0.08150812,-0.06645505,0.0139657715,0.053255484,0.018390978,-0.019827202,-0.032596726,-0.15105636,0.03566961,-0.008928962,0.013704612,-0.052159045,-0.056976397,-0.022445379,0.11790805,-0.02669738,0.071716145,-0.009170325,-0.026375303,0.061015975,-0.016821798,-0.027499693,0.029396532,-0.059681103,-0.02979317,0.10678002,-0.03533747,0.06626326,-0.06876532,-0.046516843,-0.035989344,-0.01643829,-0.05045571,0.06348689,0.046185173,0.07417717,0.011521269,-0.0694769,0.05179093,0.0795312,0.02377198,-0.04889857,-0.038667392,-0.028204434,0.06602436,-0.06787417,-0.029525736,0.13316192,0.022979708,-0.013879641,-0.061320882,-0.06306194,0.03399016,0.03810763,0.07027893,0.039301388,-0.01959081,-0.0113875605,0.016230488,0.015133741,-0.028107809,0.05741914,-0.06464799,0.002920348,-0.022993729,0.03867196,-0.029895272,-0.06533735,0.008510235,-0.0055328403,-3.1032184e-33,0.10377209,-0.09799428,-0.0103058405,-0.044795908,-0.07710964,0.057431273,0.063737094,-0.0022880107,0.060757753,-0.0771241,0.12017668,-0.0684312,0.041953065,-0.016683055,0.06882405,0.028725944,-0.038578324,0.03465101,-0.03818118,0.0474764,0.0058597536,0.031274773,-0.001861558,0.053819764,-0.014705524,0.0023504593,-0.0024418451,0.0872674,0.106686324,-0.02662169,-0.03421187,0.016696122,-0.033655297,-0.07668655,0.005630407,0.06528725,-0.07946904,0.042445946,-0.018986864,0.0011226886,-0.0054582,0.02249277,-0.040959027,0.09598218,-0.004273129,0.04044647,-0.051575277,0.03066188,0.04574742,-0.07405078,0.057463363,-0.02302915,-0.07452667,-0.009035389,-0.0020584457,0.021892918,0.031204596,0.02238367,-0.028690567,-0.0017427071,-0.07706899,-0.032383773,-0.016416267,-0.004956162,0.08726453,0.032017305,0.012014617,-0.0024413662,0.009872177,-0.037003722,-0.0010065727,-0.02106013,0.061214883,-0.043513183,-0.011205059,0.028599542,-0.09661752,-0.006074359,0.00090457767,-0.013584461,-0.07132685,-0.05072394,0.0067355023,-0.025738819,-0.018918699,-0.09218446,0.023375321,0.091756195,-0.016112082,0.010727488,0.036353253,-0.07058521,0.019954063,0.10461176,-0.0127804205,-3.627838e-08,0.083647065,-0.021338593,0.026396673,-0.01571284,-0.047506522,0.052584257,-0.026307916,0.025861206,0.045024473,-0.07197228,0.054809865,0.10549266,-0.023753256,0.059846036,0.012840468,-0.0036365553,-0.043208554,0.042288315,0.0043082493,-0.043799546,-0.08285342,-0.07508462,-0.020504327,-0.04808131,0.054132357,-0.045923967,0.036212604,0.020785267,-0.039902885,-0.048025582,-0.08547678,-0.034397133,0.08147248,0.026529588,0.11140028,0.07503149,-0.055610906,-0.0519973,-0.0053829486,0.0028183293,0.0027453064,-0.006271094,-0.12330978,0.0021308244,0.06372169,-0.044114057,0.052850977,0.022659663,-0.049110834,0.036185402,0.0036359015,0.016211642,-0.034603894,-0.07246921,-0.018878626,0.02440657,0.0046450235,-0.09622624,-0.049801785,-0.04792854,0.054246437,-0.011537259,0.10661974,-0.017410966 +3.7.1.14,This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation. The first step of the enzyme mechanism involves a reversible keto-enol tautomerization [4].,384,0.99999994,-0.016364966,-0.00848955,-0.0029340633,-0.048697453,0.050497454,0.006531575,-0.02282634,-0.020299142,-0.008717324,0.061420284,0.037348833,0.012903272,-0.075996995,-0.010382539,-0.062339276,0.0806261,-0.13433215,0.06422301,-0.03413978,-0.058094878,0.032878816,-0.016647441,0.033502337,0.042030714,0.06463262,0.030537475,0.10682242,0.015701458,-0.013392487,-0.08019584,0.059182923,-0.0035829637,-0.017774222,-0.031097852,0.021420531,0.052520715,-0.041689165,-0.064481884,0.02867314,-0.0038228983,0.046365876,-0.091786586,-0.07157456,-0.07907266,-0.009987472,-0.028080406,-0.050313205,0.06257798,0.05900234,-0.056415904,0.0062314267,-0.042541932,-0.0034613404,-0.010408147,-0.03772627,0.07872004,-0.06490802,0.04071479,-0.01143152,0.07135886,0.035516452,-0.036885463,-0.05645533,0.0071376986,0.0018291752,-0.013517486,0.020512385,-0.074014194,0.043256436,0.049436685,-0.06606638,-0.10187542,-0.047084183,0.016074631,0.019061802,0.007732317,0.004928995,-0.02026013,0.019961178,-0.04300983,0.07508069,0.014151849,0.07750249,0.025623986,0.054502334,-0.012164829,0.029277133,-0.0493079,0.13378271,0.040469695,0.023830883,-0.00720182,0.015397616,0.0042779595,-0.033562664,0.044359256,-0.008969678,0.011151129,-0.010737465,0.036055326,0.025414912,0.03151275,4.5924244e-05,-0.12105246,-0.053758774,0.03930033,0.059300605,0.061314754,0.012869392,-0.014312756,-0.031720057,-0.031113708,0.09681609,-0.0018180895,-0.020818854,0.05660702,0.019389955,-0.0056892834,-0.035023954,-0.03213815,-0.030513909,-0.00874759,-0.010465335,0.046731908,-0.10892562,0.033745017,-0.05339807,2.1097842e-33,0.047961008,0.02922468,0.02145518,-0.001178609,0.0020519565,-0.03364371,-0.070254944,0.03233371,-0.07839684,-0.09388044,-0.078213066,-0.08916017,-0.0011116352,-0.03613596,-0.00038102505,-0.07630923,-0.0012655908,0.087884285,0.086538814,-0.0037655977,-0.011527133,0.01731859,-0.047959674,-0.029015211,-0.015648453,0.03283297,0.009081434,0.025032204,-0.04478304,-0.02079962,0.002691085,-0.059153214,-0.13982326,0.020690275,-0.0051678615,-0.013237709,0.010623869,-0.036563274,0.010051544,0.10796683,-0.056254525,-0.00057895225,0.015316547,-0.0013960238,-0.044573218,-0.012409983,0.043212358,0.08357109,0.056621533,0.0789814,0.044476096,-0.030919556,0.04316824,0.014566049,-0.05830158,0.053969722,0.026774712,-0.042476475,0.042194698,-0.029539123,-0.00013514345,0.06070781,-0.04036961,0.013522243,-0.0037031109,0.0066091362,-0.073077515,-0.0694193,-0.0019587856,0.0369466,-0.08477735,0.023015218,0.07563582,-0.0049589765,0.10096868,-0.018046401,-0.100048445,-0.016142877,0.013954239,0.011001579,-0.036955804,-0.017341152,-0.0393084,0.022325741,-0.007960373,0.0060840813,-0.043161154,-0.107794896,-0.013413477,0.036060315,0.01961189,-0.11122063,0.0030310499,0.06911893,0.040190104,-2.2373654e-33,0.10866263,-0.044620104,0.033492915,-0.016481888,-0.052405413,0.02055608,0.0018499317,0.014870595,0.011052849,-0.0166489,0.06830991,-0.05289531,0.09260563,-0.023162553,0.03202122,0.04323328,0.0132888295,0.05515514,-0.017225029,-0.029137185,0.012546252,0.059297286,-0.039959144,0.061691597,-0.028405761,0.027799992,0.053935822,0.07973809,0.1071686,0.037645955,-0.047637448,-0.041389216,-0.024566257,0.03424679,0.012054484,0.13463601,-0.05303333,-0.032114886,0.003175317,-0.04486764,-0.0080199,0.052661162,-0.00037372526,-0.018414455,0.0594174,0.036289465,-0.019965095,0.059834067,-0.037972886,-0.113466166,0.0572845,0.11123732,-0.041261278,0.0060378923,0.005416394,0.080147125,-0.00013901462,-0.01356909,-0.048134048,0.0010306741,-0.05646543,-0.062857665,0.119553685,0.03223074,0.041704368,0.024106799,-0.01617152,0.11500516,0.017710224,-0.080844365,0.07535816,-0.020514103,0.04372574,0.06641001,0.032512993,-0.055614274,-0.025140515,-0.06017327,0.00076501333,-0.018528633,0.045522515,-0.1162497,-0.004365228,-0.094955474,-0.025631635,-0.07685249,0.01649261,0.01928126,0.00075918424,0.080379725,0.044811588,-0.01924817,-0.058462102,0.14427501,0.07774882,-2.7724292e-08,0.031131996,-0.09123957,0.009111399,-0.030325403,0.03403951,0.027973957,0.037913874,0.0345217,0.03759371,-0.08226979,-0.04978882,0.054422546,-0.013951149,0.07869128,0.01303588,0.0882559,-0.07018786,0.040578533,-0.01606312,-0.049936447,-0.09001233,-0.057874337,-0.095088385,0.036255166,0.018565586,-0.026817895,0.04347211,0.12131802,0.0013316576,-0.029265454,-0.014039515,0.048513737,-0.005306499,0.059784126,0.0017572417,0.0747769,-0.06951191,-0.00074698305,-0.002270298,0.048464112,-0.05695161,0.0029565461,-0.053738885,0.0031823218,-0.025853524,0.036809336,0.034375973,0.0315959,-0.05395718,-0.021464055,0.05405753,-0.006112723,-0.0140908975,-0.044221465,-0.094006486,-0.0040971925,-0.008072122,-0.02145447,0.011153915,-0.074450664,-0.030187009,0.04847509,0.1343726,-0.038589504 +4.1.1.93,"The enzyme catalyses both the carboxylation and decarboxylation reactions. However, while bicarbonate is the preferred substrate for the carboxylation reaction, decarboxylation produces carbon dioxide. The enzyme is activated by carboxylic acids. ",384,1.0,0.022168873,0.0063331155,-0.0121986745,-0.03383052,0.015090507,0.035075024,-0.10559819,0.031049287,0.041630857,0.0020810298,-0.062380433,-0.072486326,-0.11424389,0.006403223,0.03988551,0.077238455,0.018119907,0.041456755,0.07799103,-0.04046815,0.07970462,-0.047264382,-0.053300176,0.03408052,0.031516563,-0.023323514,0.043354835,-0.056767516,-0.010374004,-0.03737633,-0.05230876,-0.0033132897,-0.0021420808,-0.016383253,-0.028436342,0.06298099,-0.05107449,-0.038371865,0.05509127,0.02768522,-0.04207535,-0.018036027,-0.039801788,-0.08664369,-0.009254059,0.013646646,0.01913411,0.0625709,-0.068766184,-0.07142746,-0.0048429584,0.012838983,-0.071501486,-0.055706337,-0.0037563308,-0.00010715022,-0.0042523346,0.029441908,-0.00886088,-0.0227929,0.03168394,-0.0021750422,-0.0198648,-0.010160823,0.036943484,-0.0537088,0.0375047,-0.04995873,0.04115751,-0.03787484,-0.057020042,-0.015012494,-0.029967912,-0.06771345,0.02906907,-0.056947447,-0.032978877,-0.017189773,0.06052723,0.04695566,0.03124494,-0.0026305998,0.01368315,-0.031888627,0.025037086,0.027123969,-0.024767527,0.04988587,-0.011469066,0.022479279,0.0060049063,0.015222268,0.033466935,0.012469164,-0.047769696,-0.026594417,0.07104657,0.05037341,0.0964914,-0.06982441,0.037603322,0.03800578,-0.042802725,-0.15127414,-0.051306926,0.043600336,0.042429954,0.053332422,0.08266144,0.044564616,-0.03338776,0.04223043,0.08977133,0.018134838,-0.05137302,0.16375917,0.020608904,-0.065718375,-0.0078135785,0.044365935,0.05129304,-0.025867973,0.010594196,0.06517671,-0.052981347,0.06495448,-0.068804316,2.3155962e-33,0.023743985,0.0025142834,0.019158091,0.015014189,0.0183362,-0.004528277,-0.073727034,0.008061807,-0.06542472,-0.043926857,-0.026277525,-0.016525775,0.074815795,0.07377659,0.029467303,-0.04741962,-0.04212997,0.0059775105,-0.0026782774,0.009474257,-0.014205898,0.055831455,-0.035690527,0.112913765,0.06442218,0.026203658,0.015827741,0.034733646,-0.05035391,-0.029041396,0.03261191,-0.07327959,-0.05341441,0.003395186,0.06803758,-0.035061676,-0.026378814,-0.013149748,-0.05221945,0.009280002,0.051628865,0.013629802,0.008118525,-0.059494156,0.05527223,-0.10424783,-0.014367235,0.1080646,0.031257436,0.01898002,0.04868849,0.0368895,0.0048742946,-0.005678838,0.015609834,0.06056436,0.0005881952,-0.024221469,0.044445135,0.05712545,-0.011218806,0.03814852,0.033931967,-0.0015441019,-0.030055253,0.021375244,-0.059104074,-0.02352582,0.010251337,0.049137555,-0.022988532,0.008269293,0.03947177,0.027324,0.05458186,-0.05149719,-0.05512386,-0.017200798,0.05554701,-0.049250167,0.012560536,0.05338277,0.010347106,-0.093019806,-0.0743828,-0.05784106,-0.05789417,-0.031770937,-0.023811132,0.13165595,-0.0569286,-0.017354535,-0.022419473,0.04544759,0.07187759,-3.7389397e-33,0.1197647,-0.09215049,-0.02678348,-0.07571527,-0.04813126,0.063727975,0.04245187,-0.1746781,0.066481836,-0.024222218,-0.030733187,0.00724361,0.05031033,0.06510413,0.03664845,-0.035860244,0.007748707,0.021474056,-0.015382935,-0.035715826,0.019324893,0.06581173,-0.003937408,0.0014887819,0.018034475,-0.02113922,-0.05283905,0.07175932,0.16980702,0.028058223,0.007843989,0.019672655,0.015695078,-0.0040453062,-0.055567026,0.08225231,-0.03964222,0.041410252,0.017887939,0.03147384,-0.07393143,-0.0016868806,-0.06066727,0.06812665,0.023269368,0.023465924,-0.032987658,-0.03743062,0.013321168,-0.058151152,0.021097515,0.014131657,-0.047464143,-0.022900121,-0.014208801,0.09581413,0.0018900982,-0.06629369,0.032668483,-0.008902876,-0.045356598,-0.018236686,0.053635057,-0.09631718,-0.028171917,-0.0029279443,-0.080376685,0.06455419,0.08268275,-0.068354785,0.08525236,0.070326895,-0.022162765,0.073770314,-0.05789807,-0.039846487,-0.052213013,-0.035650842,0.0055410597,-0.043368988,-0.049957804,0.030218055,0.045006245,-0.014418422,-0.058040705,-0.074322924,-0.011018242,0.007484271,-0.051232647,0.020415654,-0.01887086,-0.0568037,0.019556351,0.033331655,0.055834766,-3.0714062e-08,-0.035519928,-0.042974327,0.07128024,0.017195238,-0.09092047,0.04109869,0.0631414,0.031815626,-0.044318914,-0.09114502,-0.05952655,0.0032778168,0.009132387,0.027102644,0.08704541,0.0293889,-0.006004821,-0.01839282,-0.023469359,0.013966818,-0.034554437,-0.03793776,-0.0868683,0.055650912,-0.02625282,-0.050724253,0.051616773,0.095859036,-0.008266298,0.044830658,-0.035990957,0.06301082,0.053123146,-0.022804994,0.0011412482,-0.06055395,-0.03264454,-0.02256782,-0.020946436,-0.011022468,0.08232684,-0.035482638,-0.083610184,-0.023218056,-0.017840719,-0.022991955,0.020060334,-0.021345954,0.034277055,0.01971341,0.11673113,-0.06890094,-0.014029203,0.028611062,0.023702146,0.035222735,-0.05715695,-0.0803783,0.057954397,-0.027408678,0.037012897,0.10380898,0.20764372,-0.098912574 +4.1.2.48,"Requires pyridoxal phosphate. The low-specificity L-threonine aldolase can act on both L-threonine and L-allo-threonine [1,2]. The enzyme from Escherichia coli can also act on L-threo-phenylserine and L-erythro-phenylserine [4]. The enzyme can also catalyse the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis [3]. Different from EC 4.1.2.5, L-threonine aldolase, and EC 4.1.2.49, L-allo-threonine aldolase.",384,1.0,-0.05303824,-0.09581125,-0.006626291,-0.032452874,-0.003972,0.06710807,-0.120236695,0.019536695,0.039055265,0.009697323,-0.0048439973,0.017192792,-0.038869087,0.07977078,-0.03527461,0.027397856,-0.041103747,0.025192885,-0.0047670854,-0.043876942,0.12890607,-0.0022456325,-0.05565288,0.0071335793,0.08750703,0.00638714,0.030026559,-0.020698287,-0.018495258,-0.039046604,-0.08711906,-0.10243296,0.004717733,-0.04967335,0.04499472,0.11144921,-0.08942528,-0.040593367,0.10303956,-0.006763212,0.06294369,-0.10058596,-0.03446835,-0.02472962,-0.02087849,0.011048593,0.06010228,0.037953883,0.0012890713,-0.0063350033,-0.08385819,-0.0014597236,-0.04760929,-0.028907474,-0.027758688,-0.0055846153,-0.007279586,0.0065500382,0.014469595,0.0152873425,-0.008053939,-0.029643869,-0.016390966,-0.0043408256,-0.032312155,-0.038446024,0.021689145,-0.01749351,0.000641412,-0.07070722,0.017511409,-0.04393847,0.03549218,0.04024681,0.06914613,0.013855117,-0.028147738,0.017440937,-0.042056616,0.01915334,0.094908096,-0.0014093163,0.02563923,0.07470249,0.0241144,-0.012085128,-0.026095005,0.05956293,0.035209883,-0.033540774,0.042550612,-0.009819502,-0.032251332,0.0045269933,0.063928515,-0.014579335,-0.017459309,-0.019030506,-0.022923317,-0.063320786,-0.02349193,0.008063402,-0.038360544,-0.04332827,0.03531629,0.046766125,0.029509723,0.08445826,0.028755337,-0.034221437,-0.020251034,0.008723328,0.046049424,0.003107688,-0.037099008,0.05038178,0.036685474,-0.068408184,-0.064950354,-7.0807044e-05,0.020792305,-0.050878588,0.09680691,0.09285765,-0.021470405,0.030578176,-0.06827391,5.8055616e-33,0.12488803,0.08447002,0.024132846,-0.032743055,0.05041285,0.0031462908,-0.08970475,0.026678946,-0.058873907,-0.043642662,-0.013386497,-0.052510265,0.007190202,0.041864507,-0.059486657,-0.022487773,-0.012188774,0.0094416,0.102043726,-0.031994984,-0.008692732,0.019030886,-0.028546963,0.1170439,-0.017158903,0.066793114,0.043800745,0.05479871,-0.038350694,-0.026181608,-0.021351548,-0.10228314,-0.055842545,-0.031518687,0.03768142,-0.034938686,-0.13578103,0.0064171012,0.03149982,0.09180142,-0.030054023,0.09232057,-0.015008881,-0.06392896,0.039245002,-0.057724647,-0.027868254,0.08408336,-0.026086606,0.10603317,0.08133183,-0.055899188,0.051977936,0.013797688,-0.10215814,-0.0033110215,-0.0041342336,0.008327937,0.035176422,0.009573283,0.10781381,0.06448458,0.031448685,0.010405579,-0.014974256,-0.013014004,-0.04056019,-0.034332924,-0.04511089,0.10655892,-0.00080407644,-0.046928618,0.06517468,-0.029222798,0.036205746,-0.081490465,-0.05371328,0.02243601,0.012800667,-0.0037027008,0.04269531,0.03318585,0.039638884,0.041499414,-0.068220675,0.007484572,0.03290747,-0.02113271,0.014041812,0.076366544,-0.0648292,-0.07881445,-0.019725,0.027336223,0.0026658596,-5.1157973e-33,0.1365441,-0.098192155,0.1310135,-0.023834959,-0.09055565,0.024048487,0.011083491,-0.06089028,0.0479015,0.022005113,0.08720133,0.0020500538,0.04360084,-0.024596317,0.011335345,0.02105542,-0.043147016,-0.016895393,-0.009198267,0.018152565,0.026040105,0.027306644,-0.0428074,-0.010933443,0.12477671,-0.010052998,0.00015860224,0.076633595,0.055757366,0.059871763,-0.06369767,0.0040342975,-0.04832872,-0.07034298,-0.03375412,0.086835265,-0.0830983,0.062678516,0.034605004,-0.0072683287,0.049437884,-0.008164435,0.06965032,0.013721077,0.041440587,0.02792623,-0.0043452224,-0.07781416,-0.036908522,-0.05417614,0.00018101664,0.03643459,-0.038161017,0.055555187,-0.01583429,0.0540906,0.03413986,0.013519765,-0.04264553,-0.07507747,-0.060634285,-0.101144016,0.056649983,-0.024560772,0.02248174,0.022304954,-0.030063491,0.058859996,0.05128981,0.03424606,0.094670966,-0.04102351,0.062335745,0.06568268,0.00314725,0.050286368,-0.0744272,0.006319818,-0.016903698,-0.0053677354,-0.011417912,-0.006866106,-0.029105332,-0.041236706,-0.012325189,-0.057410322,0.12575021,0.11406437,-0.005553879,0.035652317,0.02244264,-0.027912412,0.024395183,-0.028049307,0.03303978,-5.2994597e-08,0.003956946,-0.07844084,0.0032939017,-0.0039037934,-0.01068847,-0.027943894,0.013798408,-0.0011603546,0.027807094,-0.033940256,-0.033259686,0.0020470193,-0.014414241,-0.04906343,0.061375324,0.014143838,-0.099109255,0.022959774,0.0020714013,0.02687444,-0.08012165,-0.010724577,-0.14959419,-0.04374026,0.032883838,-0.04465285,0.009374607,-0.05120244,-0.032236446,-0.016542131,0.048538778,-0.010867875,0.0049330276,-0.10709339,-0.025603924,0.017132076,-0.07992044,0.0008382246,0.0038894447,-0.04621725,-0.03701536,-0.048514538,-0.040838193,0.057182927,0.017934717,0.05904514,-0.0039052027,-0.02366067,-0.03056446,0.009855305,0.08009942,-0.03456631,0.009607679,-0.086595595,-0.07375323,0.08172543,0.07020053,-0.032009657,0.0064743822,-0.08028233,0.018467588,0.009940175,0.12571475,-0.06251623 +4.1.2.49,"Requires pyridoxal phosphate. This enzyme, characterized from the bacterium Aeromonas jandaei, is specific for L-allo-threonine and can not act on either L-threonine or L-serine. Different from EC 4.1.2.5, L-threonine aldolase, and EC 4.1.2.48, low-specificity L-threonine aldolase. A previously listed enzyme with this name, EC 4.1.2.6, was deleted in 1971 after it was found to be identical to EC 2.1.2.1, glycine hydroxymethyltransferase.",384,1.0,-0.031358507,-0.03507809,-0.034092203,-0.054668285,0.07132716,0.022681002,-0.12142568,0.035692513,0.035529524,-0.040029358,0.03366309,-0.028277086,-0.0812325,0.050268497,-0.06829814,0.030139722,-0.0607274,-0.049481984,-0.0075239446,-0.010227231,0.07831245,0.05065582,-0.039196927,0.00568024,0.07900285,0.02387833,-0.010253309,0.01506194,-0.03154822,-0.052402638,-0.03602801,-0.04297105,0.05233627,-0.081872426,0.07301545,0.06948429,-0.071391225,-0.055065505,0.083744325,0.03611042,0.047772896,-0.09227461,-0.02287228,-0.06765201,-0.041875508,-0.006391483,0.07255414,-0.0069897743,0.059789106,0.0001334462,-0.065368555,-0.053955164,-0.008773119,-0.008358703,-0.013801854,-0.037129357,-0.011022018,-0.020165015,-0.047840677,-0.006305622,0.002294249,-5.0673985e-05,0.0020013668,-0.017492253,0.021417655,-0.03574431,0.047224697,-0.1132009,0.060362667,-0.052951615,-0.07581917,-0.07208511,0.088364996,0.122363225,0.026319446,0.03949089,-0.025876204,0.01940674,0.027109835,-0.014876292,0.04099707,-0.036001813,-0.019958025,0.014347874,0.025774304,-0.010931069,-0.031885266,0.015893482,0.06095981,0.0015290162,0.02173619,-0.031226989,0.012246722,-0.028152633,0.048641007,0.010950131,-0.026509177,0.043065157,-0.028885635,-0.04382678,-0.0012694676,0.05007128,-0.07356754,-0.03692245,-0.05015336,0.04209476,0.019445335,0.06609359,0.021405555,-0.070317626,-0.009560738,-0.02472162,0.07303142,0.010023757,-0.019402953,0.045868825,0.024324572,-0.08134725,-0.051254205,-0.0076056723,0.0009071088,-0.09120191,0.1261334,0.067221835,0.0056811124,0.09296449,-0.09225073,2.4479137e-33,0.100261554,0.11264783,0.013618735,-0.07473625,0.015204163,-0.0016850047,-0.10767542,0.072938025,-0.01960409,-0.112099364,-0.04643307,-0.04430889,0.017601026,-0.016976636,-0.032003302,-0.020425113,-0.0052584815,0.024365881,0.068470165,-0.044802364,0.035681162,-0.008978676,0.0006911388,0.06556717,-0.0064763743,0.08960561,0.08860603,0.00825995,0.020639885,0.008214803,0.0027471166,-0.10831846,-0.0371176,-0.011954104,0.024519611,0.0053227697,-0.08101684,-0.027317949,0.019176407,0.068658106,0.00095866405,0.1009691,0.05584872,-0.05583678,0.049129363,-0.060642682,-0.05268913,0.12606318,0.025101876,0.043198474,0.035838623,-0.07001309,0.06370689,-0.030176593,-0.06868987,-0.011505951,-0.020990267,0.013504262,0.01791447,0.026943598,0.0639847,0.09900247,-0.030540343,0.03899614,-0.034400094,0.013625606,-0.043296427,-0.01481029,-0.04306852,0.07460409,0.007263196,-0.060911145,0.10112102,0.014271144,0.042286973,-0.11558158,-0.059924107,0.013470587,0.00029246227,0.0031327612,0.019528506,0.047803726,0.031761546,0.016170058,-0.07002452,-0.048089985,0.052450392,-0.01791643,0.0021369143,0.05998926,-0.016116839,-0.09040316,-0.061607007,0.043526884,-0.016524501,-2.366208e-33,0.05973672,-0.08458257,0.07236707,-0.041198008,-0.038271144,0.052305013,0.03781073,0.027083058,0.037672408,-0.012909522,0.14708401,-0.02285502,0.057581697,-0.062400915,0.08181864,-0.02278616,-0.07724633,-0.031562563,-0.0051740017,0.029368527,0.06395459,-0.0033427817,-0.034241494,0.027897218,0.09752743,0.0019824817,0.019318806,0.07190146,0.03791662,0.019844985,-0.06972915,0.07797503,-0.0563013,-0.05121978,-0.015849384,0.024619674,-0.04330584,0.038896352,0.025857797,0.006246753,0.03508985,0.035553124,0.031356074,0.049796265,0.03349967,0.06326099,-0.023639595,-0.021459773,0.041191187,-0.0723701,-0.0058999765,0.00720894,-0.022900026,0.015997684,0.009526077,0.075645335,0.015766755,0.038421474,-0.08028424,-0.046197314,-0.039840635,-0.08213305,0.031387985,0.02464857,0.038851906,0.041503508,-0.043375354,0.06423058,0.021218332,0.039529383,0.073256,-0.062197674,0.03892744,0.038722128,-0.05077063,0.026963199,-0.098485716,0.016210923,-0.0059444024,-0.030532215,-0.0010703049,-0.016462581,0.012602313,-0.058108047,0.03366518,-0.06452596,0.07932445,0.108986385,-0.030834803,0.033351917,0.0064181653,-0.022255741,-0.03958141,0.009639011,0.04913173,-4.734838e-08,0.05395126,-0.075511925,0.046861384,0.010090514,0.034421887,0.0046857377,-0.0041920347,0.022105772,0.053006865,-0.04473749,-0.015019638,0.023589998,-0.040101025,-0.031181516,0.042717345,-0.013460163,-0.07732166,0.065862834,-0.01219523,0.039258204,-0.080164805,-0.025127854,-0.1405499,-0.046278518,0.023280079,-0.022411693,0.013890201,0.020480303,-0.025600575,-0.060315017,0.018156426,-0.0050726547,0.0040854947,-0.07009246,-0.12218816,0.014168761,-0.058361452,-0.015909204,-0.051336464,-0.024027292,0.011423387,-0.0036895955,-0.07965725,0.036410455,0.087172,0.030442813,0.0063125,-0.019201053,-0.033892106,-0.03607836,0.04320356,-0.04498774,0.03264996,-0.07014664,-0.071354255,0.06354766,-0.015097766,-0.0649092,0.015154899,-0.052942585,0.077517584,-0.0031288327,0.15105344,-0.0068868874 +4.1.99.17,Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis.,384,1.0,-0.00024684938,-0.008753773,-0.11093235,0.042850208,0.05353654,0.06439849,-0.10256557,-0.023205241,-0.014404233,-0.00046585634,-0.02168244,-0.034999248,0.03291461,0.030090285,-0.027559869,0.0632383,-0.110297516,0.0330831,-0.040028993,-0.033084214,-0.027606891,0.026508376,-0.06414652,-0.03331462,-0.00092704175,0.03813352,0.07255748,-0.060942147,-0.059692033,-0.09376652,-0.04782171,-0.0015178211,0.065960914,-0.03180758,-0.017241018,0.1108897,-0.017182745,0.069189176,0.09956964,0.009479371,0.009437966,-0.0145331295,0.012062492,-0.026220595,-0.03701813,-0.033488467,-0.0059266374,0.03306894,0.016705785,-0.038447037,-0.06464709,0.0438886,-0.0535125,0.023357896,-0.0020098602,0.03489886,0.014522974,-0.016575307,0.007726428,0.054423384,0.11557947,-0.099178225,-0.025064584,-0.01340924,0.06586399,-0.029979963,0.051657055,-0.024745043,0.04543726,-0.047995497,-0.01440943,0.01586495,0.0020204976,-0.010500828,-0.020862006,0.038842198,0.015736442,-0.02572826,0.08110319,0.037142683,0.015650228,0.018992374,0.054346997,0.03503718,0.10024846,0.038370464,-0.06013846,-0.05619875,0.04942007,0.004670486,-0.013094051,0.008966278,-0.06261442,-0.025670782,-0.06762742,0.024372024,0.056821022,-0.018072244,0.022062402,0.014917097,0.0425325,0.036254507,-0.100462355,-0.021043109,-0.03345975,-0.045132734,0.04482412,0.08024796,-0.08344932,0.051107284,0.061614472,0.03052334,0.045029785,0.023405783,-0.09206916,0.08543811,0.026423823,-0.009951007,-0.058249958,-0.018592067,-0.012801271,0.09158264,0.06333846,0.021449212,-0.07536109,-0.035104923,-0.10253409,1.5443867e-33,0.07411485,0.08949486,0.024771862,0.028122177,0.04249016,-0.02637987,-0.072284706,0.021062402,-0.032348394,-0.04763152,-0.046306852,-0.04345179,0.05374675,-0.052863993,-0.06743717,-0.12295298,-0.026327543,0.0020962297,0.073237784,-0.046392176,-0.07732535,0.013748817,-0.08305373,0.050538417,-0.041658692,0.076845944,0.054425385,0.04423759,0.014601399,0.038038973,-0.070813335,0.01727186,-0.06693085,-0.0807836,0.053157024,-0.030865617,-0.0761344,-0.026722828,-0.0049522785,0.004876564,0.018224152,0.04403885,-0.052320562,-0.059594072,0.0044691074,0.01701792,-0.04670884,0.061974864,-0.020647848,0.06130401,-0.018662319,-0.06141797,0.11496602,-0.026335906,-0.09861085,-0.0729761,-0.025067788,-0.10426612,0.044404853,0.08165082,0.011086075,0.005812195,-0.06624836,0.06105256,-0.024170013,-0.0037096196,-0.050324112,-0.011591772,-0.009638473,0.0547628,0.06465219,0.049575154,0.12478926,0.02250611,-0.02017054,0.005091465,-0.008172866,0.057711046,0.005954791,-0.017209709,0.045967937,0.047358133,-0.031810917,-0.036560144,0.012604621,-0.078879565,-0.008947944,-0.07086351,-0.0080074165,0.020375317,0.011336999,-0.04002558,0.033011597,0.014263198,0.020084899,-2.6637811e-33,0.048149243,-0.04329032,0.055938374,-0.068973325,-0.0456223,0.014586982,-0.0041198814,-0.061059896,0.02974031,0.025136866,0.07425846,0.0063482104,0.05049749,-0.06345297,0.026244104,0.014890457,0.07878986,0.015047615,0.029050171,-0.019017361,0.051622916,0.011385315,-0.02366592,4.477584e-05,0.07571499,0.02022689,0.025061617,0.03618255,0.0035566064,0.11324192,0.016937608,-0.07754989,-0.041351248,0.038199093,-0.06421427,0.055388253,-0.020671261,0.036559988,0.04654595,-0.0036057634,-0.024297412,0.052595805,0.006096664,0.15533207,0.053898565,0.01837634,-0.01197798,0.030016288,-0.005020669,-0.074487,0.059673205,-0.041449275,-0.08055536,-0.067836985,-0.029974638,0.04973055,0.0443894,-0.025142182,-0.014486392,-0.04273154,-0.06631022,-0.120519325,0.05020522,-0.010212279,0.009840062,0.028581696,-0.019542929,0.04448923,0.046261348,-0.0047016847,0.031142196,0.013912135,0.07139028,0.03409756,-0.027649943,-0.0034426919,-0.031984564,0.0097148325,-0.07649321,0.036396362,-0.024208512,-0.037671186,0.014329632,-0.10068311,0.0006437213,-0.08881571,0.10006973,0.09559283,-0.01056501,0.06353008,-0.08907333,0.042191084,0.016388597,0.05386185,0.07092506,-3.8845606e-08,0.00961714,-0.10139809,-0.00451931,-0.026934028,-0.045254204,0.12259263,-0.030492248,0.020272247,0.12102489,-0.06249239,-0.007859642,0.08017418,-0.009161054,0.042929344,0.06544968,-0.014305948,-0.05534449,-0.007601552,-0.017892128,-0.0029012929,-0.074174024,-0.009936959,-0.054737993,-0.031978957,0.016958954,-0.07493605,-1.0077723e-05,-0.04944515,-0.05987965,-0.073402114,0.047860608,-0.009521871,-0.033663616,-0.0001646758,-0.0951749,-0.041946437,-0.02316143,-0.061315145,0.0006138931,0.02322535,0.0007717349,0.011670875,-0.10915723,0.090316206,-0.06335476,0.0036567685,-0.046082895,0.08210679,-0.03660152,0.02603652,-0.04261232,-0.006364201,0.019757412,-0.038117938,-0.017805137,0.034250464,-0.028267873,0.048518233,0.026102725,-0.014576984,-0.007888062,0.042470958,0.100266844,-0.03821974 +4.1.99.18,"The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). The enzyme MoaA from bacteria and the human enzyme MOCS1A each contain two oxygen-sensitive FeS clusters. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. In bacteria, the reaction is catalysed by MoaA and requires the action of MoaC. The latter protein is equivalent to the C-terminal domain of the eukaryotic enzyme MOCS1A which does not need further protein components to perform the reaction.",384,1.0,-0.0706639,-0.08848487,-0.14774488,0.05597042,0.052171335,-0.05451528,-0.08082427,-0.03355014,0.030941717,-0.05527091,0.037527565,0.010534557,-0.0013219346,0.035544757,-0.05502017,0.020614946,-0.044123046,-0.026003655,0.04562778,0.02044103,0.070550725,0.033062957,0.015560189,-0.045422688,-0.02794626,0.03193571,0.006696217,-0.008743232,0.025573505,-0.06661781,0.0402674,0.036068313,0.08644853,-0.07367587,0.07281706,0.07244288,0.05055694,-0.047176536,0.04699653,0.035611026,-0.05141798,0.06612227,0.060219474,-0.06092433,-0.027189653,-0.056593493,0.039971847,-0.013911311,-0.014872461,0.031445324,0.0039383485,-0.0566227,-0.13600849,0.018135302,0.042199638,0.029591339,-0.06038162,0.013056137,0.04641645,-0.01803835,-0.007897048,0.036389392,0.045768723,0.0796179,0.038973283,-0.1154205,0.032448877,-0.0916912,-0.016592884,-0.07149302,-0.07596765,-0.05156976,0.061887443,0.012824367,-0.06300454,0.049295086,0.015610965,-0.04867067,0.083796576,0.03703013,0.01803659,-0.002912401,-0.013540057,0.049285967,0.041014716,0.009285805,-0.021378495,-0.03357186,0.04507995,-0.014458523,0.018563788,-0.055128966,0.0072607016,-0.0107597895,-0.055273935,-0.023275066,0.086899415,0.058048617,-0.059699927,-0.011371416,-0.030247295,0.035843723,0.0098267,-0.031081753,-0.057567354,-0.02465527,-0.006717363,0.14162023,0.028052751,0.0651668,-0.03181945,0.10569949,0.058836676,-0.04651247,-0.007484802,0.0034156118,0.047565233,-0.027063936,-0.0367209,-0.031143606,0.006671713,-0.04098242,-0.013381253,0.01779554,-0.04746038,0.0027022394,-0.06828187,1.2183681e-33,0.12618771,-0.0069975983,0.025272688,-0.010945264,-0.00116353,-0.038693544,-0.02080083,-0.051744662,-0.01869785,-0.029871652,-0.011935839,-0.038592648,0.0689583,-0.04311705,-0.03242593,-0.019660654,-0.030915406,-0.09372206,0.01654506,0.0238774,-0.021621358,0.042325877,0.00037334056,0.028738879,0.0508604,0.006967128,-0.027998302,0.0068328036,0.035034414,0.0388967,-0.015243137,-0.04352109,-0.10685603,-0.02555678,0.04030254,0.016023876,-0.031418446,-0.072276674,0.030091373,-0.045347556,-0.07077328,0.007190544,-0.03426312,-0.052016225,0.046650443,0.012684971,-0.03013193,0.1303259,0.036633823,0.04699196,0.011271339,-0.023825953,0.015626367,-0.0015442834,-0.103778265,0.021588644,-0.024583979,-0.07733133,-0.0013002721,0.13064985,-0.047550876,0.012936142,-0.0004462586,0.051665332,-0.038276214,-0.060591985,-0.07246347,-0.041449945,0.04327564,0.120652385,-0.036966737,0.031350184,0.022233592,0.030222135,-0.015753258,-0.056669384,0.09709415,-0.046267234,0.024028841,-0.0015471894,0.0569384,0.022952491,0.05586348,-0.09646422,0.0044482104,0.008849473,-0.10851272,-0.030281752,-0.082064204,0.039198674,0.025747066,-0.031942528,-0.008816256,0.0033899597,-0.029928515,-2.9668144e-33,0.083431676,-0.10380011,0.096000835,-0.10299934,-0.09551973,0.035846848,0.00059758616,-0.060128547,0.0043736123,-0.02576509,-0.02719293,0.030503325,0.030372191,-0.07365814,0.04250774,-0.02700962,0.013605257,0.050111674,0.03552268,-0.0030662618,0.060102407,0.034313116,-0.023847828,-0.06765736,0.008577789,0.037135635,-0.07678746,0.044882655,0.052689288,0.013294834,0.000104496896,-0.05460631,-0.085313395,-0.039680306,-0.042711012,-0.0027570045,-0.040576547,0.035843894,0.03770832,-0.018054202,0.019043472,0.022514174,-0.0031581882,0.07359402,0.046379887,0.010361524,-0.04275114,0.018501695,0.04142275,0.0025756261,-0.012447296,-0.01585611,-0.009351105,0.014113848,0.04238424,0.033867564,0.024210865,-0.018644812,0.008031893,0.0011200261,0.021706188,-0.0009204861,0.014843374,0.0320856,0.00966618,0.07953985,0.029726755,0.058649883,0.054338224,-0.011214702,0.0064041195,0.051271856,-0.058727913,-0.010256899,0.033755906,-0.06652914,-0.11590591,-0.004015634,-0.008335311,-0.006164238,0.0028920693,0.06339635,0.009666359,-0.07368618,0.051419847,-0.009263111,0.05202292,0.106589094,0.07768261,0.011001289,-0.09022118,-0.024377735,0.007056864,-0.024155257,0.029865704,-3.6927922e-08,-0.10627915,-0.0740941,0.036314975,-0.049101774,-0.005285997,0.14501126,-0.0073437653,-0.040673196,0.054074116,-0.036065232,0.084991165,0.1376153,0.0017755454,-0.020111745,0.01612204,0.090612106,-0.07748977,-0.028628662,0.014050229,0.022119464,0.0037039947,-0.017279735,-0.0681717,0.1646978,-0.00871813,-0.04534955,-0.023241814,0.117330916,-0.0651874,0.025098905,-0.047733296,-0.013179506,0.009135088,-0.06473192,-0.08271609,-0.05854395,0.014701252,-0.028342055,-0.053301997,0.0239743,0.022933805,0.016318899,0.023950865,0.035009064,0.002641128,0.051290642,-0.027119355,0.052225765,-0.013734566,0.035541557,0.030890077,-0.05481564,-0.050682586,0.00633919,-0.108827345,-0.051512342,-0.018678762,-0.07151898,0.0017279292,-0.006617342,-0.0032458191,0.015800746,0.13409321,-0.005922568 +4.1.99.19,"Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate. The reductant is assumed to be NADPH, which is provided by a flavoprotein:NADPH oxidoreductase system [4]. Part of the pathway for thiamine biosynthesis.",384,1.0,-0.010902684,-0.0046203686,-0.12523845,0.040997837,0.055490464,0.06884544,-0.097659506,0.00047600467,0.006426507,-0.009214381,-0.037182156,-0.0019941342,0.026697492,0.010760114,-0.043012746,0.051035885,-0.08114065,0.037942078,-0.03855876,-0.046184428,-0.021598224,0.035764363,-0.03322891,-0.042773437,0.027492033,0.023200206,0.048657965,-0.061987862,-0.09301507,-0.09453735,-0.064285606,-0.012717476,0.053449,-0.028749,-0.026671464,0.123926856,-0.0074353614,0.06699076,0.04720092,0.0059207673,0.01127531,-0.0031044143,-0.008392632,0.0013088037,-0.020043848,-0.031303044,-0.03235703,0.081602216,0.024494192,-0.008085322,-0.10078044,0.04300371,-0.042630393,0.04417716,0.039795525,0.020521482,0.034838587,-0.01954461,-0.0068169534,0.014893054,0.097493574,-0.120787255,-0.016972799,-0.0278466,0.047938883,-0.056233514,0.0630804,-0.035003163,0.035481747,-0.0801077,-0.046518404,0.033997413,-0.0052453573,-0.00059126265,-0.028859219,0.060404617,-0.014844124,-0.0050109574,0.05581814,0.04195575,0.05479771,0.027445707,0.04058945,0.04463066,0.12360043,0.0395536,-0.06885435,-0.04444564,0.04227642,0.010978915,-0.0300957,0.009427807,-0.046394464,0.0131106125,-0.095095396,0.023017561,0.06783502,-0.029575393,-0.0026211932,0.0030380446,0.035211217,0.030797236,-0.048856467,-0.025954,-0.05741212,-0.043455668,0.020478224,0.10359283,-0.08508568,0.042079136,0.0512895,-0.009713136,0.037924364,-0.0028471386,-0.07256243,0.09969208,-0.0048139826,-0.008848509,-0.09468451,-0.030394854,-0.016921466,0.11482826,0.07117508,0.0144105675,-0.040596664,-0.061821386,-0.13170688,2.8398083e-33,0.09820802,0.09432944,0.0011498616,0.040714454,0.04513625,-0.0051139756,-0.0682454,0.053450868,0.014902317,-0.041921,-0.030165339,-0.05438177,0.035819817,-0.07064432,-0.029099504,-0.09180551,-0.025400283,-0.038624875,0.055163153,-0.041075785,-0.04902154,0.022679871,-0.08471639,0.055907395,-0.052740924,0.059299592,0.007958644,0.045163535,-0.0030582466,0.042958163,-0.06153472,-0.023340322,-0.061613046,-0.06588762,0.06069142,-0.028296772,-0.08875881,-0.043219138,-0.041289974,0.039682012,-0.022921136,0.036424294,-0.049130626,-0.060590047,0.01988466,-0.012367192,-0.04512871,0.07699311,-0.008667723,0.09646933,-0.016868742,-0.057621915,0.15386888,-0.0048359116,-0.11223901,-0.04641703,-0.031141382,-0.09222113,0.021137668,0.09653763,0.021025801,0.0015505927,-0.048335683,0.070735514,-0.064172484,-0.003480238,-0.07662499,-0.031960562,0.0050627873,0.06748554,0.09417135,0.0644294,0.10919412,0.041128896,-0.011680832,-0.012076417,-0.0058525824,0.062160324,0.010807416,-0.026946817,0.03695539,0.041308895,-0.07990656,-0.018315593,0.0016147112,-0.021937191,0.022369264,-0.051300358,-0.0128080845,0.019569622,0.023711517,-0.03902772,0.02832076,-0.025850153,0.038768448,-3.409087e-33,0.071907066,-0.029414738,0.058427937,-0.064056784,-0.015634496,0.035983518,0.016545247,-0.05633196,0.017667795,-0.007274422,0.044894688,0.012956568,0.034300998,-0.031439573,0.035414968,0.014319521,0.052347597,0.028409222,0.023214111,-0.007427459,0.041902497,0.029785974,-0.02399216,-0.01824589,0.076255396,-0.011969158,0.016645996,0.020505475,0.0067722374,0.09174141,0.0055212793,-0.038938753,-0.06708049,0.02533396,-0.066688694,0.0734523,-0.054407287,0.024876239,0.023497434,0.038643606,-0.016413089,0.033899784,-0.035355374,0.107344925,0.073269255,0.036741037,-0.02640664,0.06475549,0.025014454,-0.08731271,0.088621445,-0.021451466,-0.055334352,-0.033032168,0.0007697753,0.04752488,0.049133442,0.0012881391,-0.00782578,-0.0265382,-0.060228217,-0.121848956,0.03278741,0.011584436,0.030677516,0.011033548,0.014162919,0.058789305,0.046286937,0.021609792,0.031526435,0.012692384,0.08908176,0.057663314,-0.023074843,-0.04097262,-0.04566131,0.036389012,-0.09322029,0.018159771,-0.027162084,-0.05079773,0.026847314,-0.10040395,0.0037256714,-0.09263803,0.076686755,0.06868828,-0.0077811526,0.07175956,-0.08270576,0.06280911,0.0040963646,0.04804999,0.038645543,-4.0072972e-08,0.026253419,-0.08125061,-0.0033283615,-0.018925138,-0.005627387,0.11216863,-0.006654964,0.004547161,0.08412297,-0.045126893,-0.008524676,0.11145492,0.0103292735,0.047561266,0.04610796,-0.007710127,-0.037017003,-0.0016757984,-0.010230114,-0.011939604,-0.058679946,-0.014588344,-0.091530405,-0.007680996,0.020897837,-0.074682124,-0.00701805,-0.06367383,-0.02223942,-0.090096764,0.06614133,0.002476584,0.005004158,-0.039445125,-0.1152333,-0.04153276,-0.02910179,-0.025915446,-0.009948261,0.027643321,-0.025592096,-0.009690945,-0.08244029,0.08362923,-0.045379058,-0.008538822,-0.02971637,0.045390896,-0.034715183,0.011441831,-0.055672713,0.018823292,0.020752808,-0.03731807,-0.026059275,0.036478445,0.00089407427,0.025594546,0.009392956,-0.051461697,-0.016503384,0.046000883,0.089436814,-0.03774753 +4.2.1.130,"The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).",384,1.0,-0.0019566603,-0.031877507,-0.06937791,0.0038398681,0.07351696,0.018381555,-0.1077068,0.056414396,-0.025523676,-0.022041133,0.027435182,-0.028306855,-0.06281493,0.018775892,-0.04404069,0.029121228,-0.0973209,0.04602262,-0.022057135,-0.054544162,0.1039992,-0.010062791,0.018772095,-0.0013463555,0.07104257,-0.02676638,0.013402375,-0.0054265885,-0.056196976,-0.07098377,-0.0035134573,-0.10023765,-0.037933692,0.004363084,-0.020099364,0.048186526,0.039955888,-0.036397085,0.028354172,0.029706012,0.007511699,-0.004145157,0.007993352,-0.03370909,0.006037153,-0.013279893,0.00036437987,0.021358266,-0.0016573116,-0.017745916,-0.0720423,-0.032282196,-0.036467038,0.0027864238,0.041748498,0.021216633,-0.015754681,-0.049571875,-0.030163247,0.04267218,0.0031152703,0.0010055887,-0.033450376,0.002050877,-0.03824093,-0.063811235,0.06695509,-0.08649438,-0.020867042,0.0015200315,-0.07924418,-0.09733214,-0.005691264,-0.08727784,0.029408695,0.055915784,-0.021494782,-0.07974549,0.073954426,0.021024574,0.059761375,-0.013300093,-0.0017879346,0.08166542,-0.005356135,-0.071898006,4.997254e-05,0.0039116624,0.06150217,0.028178211,-0.013755153,-0.011716355,-0.020836627,0.007910574,-0.07115565,0.054393914,-0.034707043,0.058689047,0.008145748,-0.023792079,-0.014885375,0.012966114,0.01817639,-0.06691609,-0.065127395,0.011878975,0.026885439,0.1195314,0.0618018,-0.02909816,0.006481863,0.03190415,0.03210184,0.05488607,-0.044872552,0.09836244,0.05939737,-0.057945352,-0.07113632,-0.019435521,-0.020366497,0.024373569,0.07548086,0.02052587,-0.03492195,0.006280465,-0.024290858,3.1280834e-33,0.07914156,0.056946423,0.03466527,-0.04532425,-0.0068084635,0.021720944,-0.13361135,-0.010030401,-0.027492847,0.0090553,-0.031355347,0.029001657,-0.042788405,0.028275106,-0.045658104,-0.015218489,-0.004858283,0.04772892,0.051040277,0.039722897,0.015065793,0.032082703,-0.048126187,0.016496658,0.05983702,0.08018319,0.04619606,0.011915793,0.011587562,0.019951947,-0.0023781783,-0.100039,-0.11080214,0.01517148,0.0037583644,-0.052466255,-0.02580007,-0.02950572,0.04281457,0.024539957,-0.0048894337,0.011122805,0.020200135,-0.04057484,0.014287852,0.032610305,-0.041374106,0.093725614,0.048720267,0.14232363,-0.019379457,-0.06320227,0.059794318,0.08954317,-0.0595309,-0.029663708,-0.112884514,0.02188076,0.08486682,0.048212696,0.0113149155,0.09680193,-0.02171839,0.023837782,0.0030654708,-0.00042753626,-0.038773455,-0.07242467,-0.028954351,0.069067664,-0.041425254,-0.064848095,-0.01701956,0.067162886,0.07341348,-0.081808,-0.029007109,-0.009080225,-0.0016665392,0.018433483,-0.05440818,-0.00331902,-0.0045101736,-0.023587767,-0.041363843,0.029061597,-0.028238963,-0.0060949624,-0.0026757026,-0.0004517938,0.016534286,-0.030591281,-0.0016478342,0.0032666486,0.045586042,-4.6040903e-33,0.116629824,-0.13225852,0.06420319,-0.09522298,-0.027522625,0.02028782,0.044510394,-0.016353808,0.06374833,-0.020742286,0.051836316,-0.0069810716,0.013555007,-0.022823876,0.06673213,-0.102722414,-0.0064725927,0.059196554,0.004812753,0.080780536,0.054327667,0.0975367,0.011004497,0.06386248,0.13024864,-0.004782871,0.042996705,0.0772899,0.042847086,0.038395546,-0.0251809,0.0318936,-0.016907118,-0.03397329,-0.056197107,0.05068237,-0.036035296,0.047174156,-0.021662816,0.049459975,0.030685738,0.04159349,-0.043819264,0.027582742,0.026277408,0.10642819,-0.103693046,0.05061397,0.022084223,-0.0720309,-0.00026567862,0.05567731,-0.02752557,-0.024036303,0.05818125,0.0063757147,-0.011866266,-0.05154761,-0.045704808,-0.049333304,-0.07118914,-0.057476465,-0.016331462,-0.077528976,0.029339377,0.0888954,0.036445636,-0.036282256,0.04195281,0.014529087,0.060925547,0.008838751,0.05146447,0.034648072,0.0050359797,-0.031125987,-0.11384047,-0.072649695,-0.022752259,-0.05853715,0.04705446,0.012998197,0.08458498,-0.038340952,0.007260427,-0.098523766,-0.005771412,0.10788513,-0.029762361,0.026493633,-0.037438493,-0.028064288,-0.045691215,0.051497225,0.027382132,-4.3934826e-08,0.02534327,-0.017481996,0.118258305,-0.04031704,-0.045981977,0.038199466,0.0050066835,-0.0017695165,0.09164125,-0.03465654,0.0060699084,0.1839083,0.08694598,0.02540113,-0.016157996,-0.030271994,0.01789722,0.046827193,0.0066854944,0.05970842,-0.09338086,-0.06411903,-0.11682117,0.032316267,0.02352993,-0.028848862,0.006173788,0.023908937,0.011552392,-0.089843385,0.06791389,0.015809555,0.037626255,0.033382528,-0.081373945,-0.022843774,-0.08793702,0.0065022786,-0.0032697294,-0.059036683,-0.021136783,-0.025665464,-0.019700715,0.026343275,-0.06240522,-0.016120283,-0.025372952,-0.035717644,0.016824707,0.01241768,0.044224434,-0.022876825,-0.072823435,-0.028499734,-0.056325037,-0.037579972,-0.0007713709,-0.062288433,-0.06683487,-0.06613521,0.052335143,-0.0141987875,0.13937916,-0.07395861 +4.2.2.25,"The enzyme is highly specific to gellan, especially deacetylated gellan. ",384,0.99999994,-0.09104987,-0.026278455,-0.11050826,0.008568969,-0.011247402,-0.050638482,-0.022244236,0.026843566,0.0044378717,-0.021879,0.086471066,0.048816785,-0.11007837,0.07110612,-0.025254518,-0.023959143,0.022735544,0.06787544,-0.06990551,-0.048289444,0.10352656,0.025052547,0.005128813,0.059207488,0.014322768,-0.047221325,0.047195397,-0.037733495,-0.06183175,-0.09161141,-0.04941327,0.03357949,0.07395821,-0.08108322,0.04894357,0.025641745,-0.1182655,-0.06394219,0.056301404,-0.008851951,0.022028755,-0.021220403,-0.026298357,-0.07778086,-0.01219508,-0.111576155,-0.033822287,0.027221397,0.011648545,0.067316964,-0.04896118,-0.031868912,-0.012316567,-0.07077168,-0.026022496,-0.001072013,-0.08080385,-0.017892417,-0.06037528,0.032772053,0.003192332,0.00941878,-0.044439368,0.009481341,-0.024439694,-0.042669985,0.04260346,-0.07254468,0.004904072,-0.08245618,-0.012410965,-0.115408756,0.07137427,0.016632237,0.073887184,-0.0032277033,0.057392243,0.009027463,0.0005794848,-0.044018853,0.09021063,-0.0047567044,-0.0019326807,0.037087362,0.03407336,0.10014991,0.056352515,0.037535477,0.029655702,0.06874161,0.10157545,0.030220829,-0.019761726,-0.01430119,0.005503871,-0.0011548905,0.03735276,0.059631784,-0.033480737,0.013977988,-0.0068355007,-0.016982807,0.022120578,-0.09384821,-0.02669415,-0.020666977,0.024065267,0.0049134674,0.044790354,0.0023837653,0.018558811,-0.019295562,0.022758229,0.0014584089,0.02230896,0.13015537,0.03578916,-0.048040908,-0.0030235657,0.01029723,-0.025426477,-0.07324112,0.09196126,0.05808194,-0.044033784,0.120722115,-0.10358557,-1.50409985e-33,0.002393203,0.0066914507,-0.04187989,0.039925173,-0.040344656,0.047299284,-0.07021827,-0.033805244,-0.014759286,-0.08737743,-0.10640321,0.00066226977,0.0064690914,0.033843257,0.0016302828,0.008665637,-0.004156027,0.031585958,0.03174002,0.028674593,0.11663874,0.049217813,-0.13552582,-0.07487901,-0.027429054,0.046616517,-0.044471115,-0.032620527,0.023814734,0.00104047,0.050234042,-0.13655734,0.002186435,0.03979276,0.05590502,0.05579009,-0.05064876,-0.03907053,-0.028764583,0.0006421155,0.009707205,0.00623169,0.026119687,-0.006080606,0.053078033,-0.03288219,-0.058207404,0.07234714,-0.026960425,0.027176373,0.040110238,0.054014467,0.11201613,-0.00999451,-0.056859866,0.088805005,0.032483876,-0.022797264,0.07656762,-0.002307038,-0.08094587,0.06859701,-0.025941087,-0.02376581,0.011454293,0.048762936,-0.11603729,0.013572106,-0.041630182,0.055497404,-0.01157025,-0.028893735,-0.004119734,0.01266416,-0.009329796,-0.045683075,-0.01591929,0.100338,-0.04916634,0.0051757814,-0.033351846,0.036982335,0.024316406,0.026406908,-0.05457118,0.023171365,0.024178801,-0.023159662,0.0047143693,0.042090468,0.17396544,-0.025957799,-0.11730687,0.005258678,0.08628384,-1.8504575e-34,0.115587756,-0.13074858,0.023436034,-0.05172842,-0.023400633,0.02338738,0.04720281,-0.030692436,0.067909695,-0.008436546,0.065931976,-0.011538712,0.0031599994,-0.06603706,0.002077479,0.024619354,0.0016750719,0.014541738,-0.012142922,0.014304079,-0.107029215,0.072881326,0.01863835,0.0036749032,0.034999218,-0.012963331,0.0056244438,0.059966493,-0.017914457,-0.027955132,-0.033654395,0.012344685,-0.0049506435,-0.008417926,-0.043526422,0.06069277,-0.048266917,-0.005028464,-0.010295311,-0.0019083809,-0.042307798,0.014992083,-0.055562273,0.03553511,0.035890616,0.07216397,0.0423483,0.031262945,-0.05752402,0.037524864,0.035170916,0.024435334,0.015617458,-0.02297288,0.04733787,0.040781736,0.03738787,-0.012627283,-0.047661714,-0.009342086,-0.019916017,-0.077902734,0.03303744,0.08387416,0.035478305,0.02709307,-0.051042043,0.0077512125,0.06602325,-0.0591309,0.034888435,0.022424532,-0.0143334195,0.035418734,-0.016162809,-0.018889466,-0.050812848,-0.06333553,0.037446436,-0.12769869,-0.06876739,-0.010348073,-0.021018699,-0.004437617,-0.005749678,-0.042257305,0.0052520214,0.043555986,0.004962224,0.033223685,0.027998058,-0.05329721,-0.051693473,0.024792716,0.078745656,-2.2224585e-08,0.04091267,0.0008811991,0.021984953,-0.051965024,0.011004691,0.00068905385,0.011292702,-0.0078017353,0.043798514,0.021794645,-0.060490906,0.12714322,-0.07054341,0.023059266,0.0065727415,0.045238327,-0.016400682,0.034891218,-0.03041106,-0.023536636,-0.039821822,0.017760912,-0.115837544,-0.0007468664,-0.006473185,-0.01740863,0.035397235,0.058517482,0.06504174,-0.07796164,-0.014483129,-0.025565684,-0.036432993,-0.07824475,-0.010076006,0.06786076,-0.0032373252,-0.016138269,-0.035057124,0.04864267,0.02293583,-0.08779821,0.0012409269,0.0015105681,-0.028517168,-0.042098463,0.044053197,-0.010343647,0.036733266,0.025350017,-0.024389569,0.0060910797,0.006851227,-0.08184804,-0.06897923,-0.0225903,0.024268888,0.0037694292,-0.032425214,-0.0007680122,0.030994475,0.035682626,0.20938823,0.0053919437 +4.2.3.78,"The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% (+)-alpha-barbatene, 17.8% (+)-thujopsene and 9.9% (+)-beta-chamigrene [1] plus traces of other sesquiterpenoids [2]. See EC 4.2.3.69 (+)-alpha-barbatene synthase, and EC 4.2.3.79 thujopsene synthase.",384,0.99999994,-0.020757813,-0.08109586,-0.09042575,0.012563117,0.0011089528,0.03327223,-0.031839974,0.09925227,0.080193266,0.02643864,0.029022062,-0.06713668,-0.02874104,-0.12253276,-0.035854194,0.02181176,0.004759956,0.053642947,-0.010147135,-0.08457635,-0.003983762,-0.012341063,0.006997299,0.021860678,0.10564902,-0.03751486,-0.023679914,-0.061418615,0.006577715,-0.094874404,-0.064808294,-0.0029725202,0.0790596,-0.05561768,-0.032744072,0.03724287,-0.00085174135,-0.11008754,0.09296561,0.028340532,0.09690267,0.023490584,-0.025926055,-0.020699061,-0.045249373,-0.010385719,-0.020786406,0.06985196,0.024547651,0.042391706,0.0031759304,-0.045606226,-0.03630714,0.019012934,-0.018014958,-0.06324971,0.037709158,-0.011800402,0.0070953155,0.12944117,0.028697189,0.012394338,0.023766266,-0.044738162,-0.014701196,-0.03530514,-0.051285375,0.036113407,0.06394249,-0.035271365,-0.05415163,-0.023610985,-0.02686135,-0.002920281,-0.045760676,0.05939465,0.03011987,0.06912385,-0.00126296,-0.058050912,0.06551591,-0.011648691,0.041149892,0.053503,0.02851509,0.030636739,-0.028630745,0.059845626,0.06979761,0.09105289,0.046925627,0.05073359,-0.019894373,-0.09180949,-0.04169833,0.09811296,0.0015677498,-0.019878741,-0.023106178,-0.032324437,-9.380655e-06,0.06036921,-0.0337521,-0.12369164,-0.06271392,0.055542298,-0.02202666,-0.027000127,0.014332426,-0.0051338705,0.019089535,-0.015100758,0.0046940753,0.00696787,-0.007302463,0.05135003,0.03131448,-0.03545373,-0.0014482673,-0.037856195,-0.032056157,0.03242635,0.030017868,0.03274197,-0.06466508,-0.017962214,-0.08496745,1.8708182e-33,0.058277056,0.118473716,-0.04609127,0.007577265,-0.017065624,-0.0047750734,-0.07223043,0.13070095,-0.07053015,-0.077369325,-0.11314975,-0.11534006,0.014744569,0.0070538768,0.05234988,-0.05420218,0.010901151,-0.026425464,0.064578936,-0.06486843,-0.07646407,-0.030644307,-0.084773704,0.04757785,-0.0025114806,-0.007828981,0.051338978,0.014281113,-0.007914267,-0.05534166,-0.026871804,-0.0066596563,0.024222843,-0.042136535,0.025015136,-0.017436247,-0.027298298,0.0030847464,-0.09374682,0.069932275,0.005343467,0.07875739,-0.008165125,-0.039204467,0.009307857,-0.051284682,0.000856086,-0.034904346,0.14666747,0.01762492,-0.048034925,0.060020857,0.15152264,-3.9070533e-06,-0.04857119,0.014028851,-0.03435377,-0.003871147,0.059391793,0.0554535,-0.0083117,0.085042715,-0.036849484,-0.024128351,-0.07568969,0.13041054,-0.093691185,-0.03276901,-0.040188376,0.06134916,-0.008184505,-0.062126175,-0.008542116,-0.06940363,0.074226126,0.01162064,-0.106327094,0.009894311,0.038961403,-0.033428345,-0.01815107,-0.002801448,-0.023523036,-0.0021620258,-0.0085024685,-0.069631204,0.011768173,0.03728742,0.019997025,0.05669886,0.095326126,-0.09934683,-0.015929494,0.01804487,0.026857298,-1.1912781e-33,-0.012828144,-0.057312388,0.008373569,-0.038756464,-0.02983166,0.06227889,-0.027861066,-0.06031458,-0.052251615,0.038386688,0.044243105,-0.00058552984,0.036321133,-0.070301786,0.005183342,-0.018080622,0.02552556,0.0773779,-0.0042446516,-0.041135315,0.034562957,0.032996967,0.1046019,0.051749125,0.014973524,0.021254558,0.044331383,0.081985764,0.043323882,-0.0020919596,0.034908906,-0.044137567,-0.016460724,0.0066440105,-0.09679865,0.011686452,-0.0225501,0.03388756,0.042944334,0.04401229,0.013495269,0.0075816256,-0.0130403405,0.09505235,0.08479198,0.020824824,-0.07595089,0.0025711793,0.020412402,-0.036588147,0.07498916,0.035928607,-0.054752834,0.041845575,-0.0011073758,-0.001243685,-0.0036074885,0.06352723,0.00028157298,-0.049883794,-0.041922636,-0.07698716,-0.017393434,-0.040676296,0.07730374,0.045614164,0.009879109,0.09989258,0.010659425,0.025249142,0.08935214,0.044675305,0.009838937,0.045764893,0.0073516495,-0.037816882,0.042770874,-0.09686546,-0.03427362,-0.04707021,-0.025528252,0.019077389,-0.004409489,-0.043595195,-0.050509736,-0.05333082,0.038916066,0.0793759,0.013271472,0.107512824,-0.025642466,0.0047604353,-0.06327262,0.065454245,0.12852505,-4.524163e-08,0.005224032,-0.044301186,0.0017194821,0.020601958,-0.0013126861,0.031207358,-0.008220192,0.0253155,-0.014679667,-0.01722699,-0.036970694,0.04833878,0.00021650243,0.042187706,0.06430896,-0.04641824,0.054817308,0.07214925,-0.0024192387,0.019914024,0.040693272,0.03142421,-0.07478354,-0.0147126485,-0.02956619,-0.082620054,-0.03674874,-0.023742782,0.028041802,-0.030358601,0.06236875,0.0069663483,0.0070846993,-0.071796246,-0.055729903,-0.019131664,-0.0270461,-0.0450093,-0.012541075,0.007995858,-0.019276798,-0.04986898,-0.0704671,0.041959476,-0.03602927,-0.014710472,0.03625752,-0.0066967276,0.042195376,0.04177313,0.045884944,-0.022932442,0.033846535,-0.08375556,-0.04812786,-0.037634075,-0.037151445,-0.0318486,-0.019853974,-0.04127392,0.054105993,-0.047849447,0.17711647,-0.018606696 +4.2.3.79,"The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% (+)-alpha-barbatene, 17.8% (+)-thujopsene and 9.9% (+)-beta-chamigrene [1] plus traces of other sesquiterpenoids [2]. See EC 4.2.3.69 (+)-alpha-barbatene synthase, and EC 4.2.3.78 beta-chamigrene synthase.",384,0.9999999,-0.030489706,-0.08760177,-0.08914723,0.014833264,-0.0074990867,0.035311993,-0.033861954,0.096292846,0.08131934,0.027007116,0.03367932,-0.06579598,-0.018938702,-0.114053495,-0.03678125,0.016746564,0.003976324,0.04912831,-0.012907113,-0.08674297,-0.005816876,-0.010923397,0.0009972415,0.029960452,0.112219095,-0.03389911,-0.02241301,-0.057240915,0.003090591,-0.09861457,-0.065000184,-0.0002551626,0.07548179,-0.056842446,-0.03170615,0.027347617,0.00022102828,-0.10750043,0.11022519,0.0319336,0.09325806,0.031389672,-0.021492695,-0.02032672,-0.036627702,-0.015900163,-0.017811611,0.06998735,0.03258587,0.042253558,0.003887478,-0.045947477,-0.035965297,0.021483162,-0.012819635,-0.061678298,0.031701628,-0.0221161,0.015406363,0.12948577,0.02484653,0.011820333,0.014276061,-0.04219633,-0.022388995,-0.036247976,-0.05427047,0.026272604,0.06350309,-0.041211788,-0.05839703,-0.037460834,-0.023393337,1.3684168e-05,-0.043445565,0.05480792,0.027143117,0.07201766,-0.008799819,-0.054816533,0.064935215,-0.013271741,0.04398215,0.0518656,0.037358277,0.031234246,-0.021512207,0.06022983,0.0788322,0.08668486,0.0419496,0.046598326,-0.023435839,-0.08852458,-0.046275843,0.09856118,0.00030180268,-0.022340845,-0.023535898,-0.028875034,-0.0017904525,0.062221847,-0.031142905,-0.121508956,-0.049810614,0.058165688,-0.015887849,-0.01701994,0.013670823,-0.0059863874,0.023927314,-0.011497724,0.0020346576,0.009586957,-0.006673814,0.059004754,0.03153077,-0.03412586,-0.005413091,-0.037636504,-0.026182419,0.028190354,0.024451,0.023730014,-0.06518145,-0.017134385,-0.08153489,1.5634828e-33,0.05673972,0.11486643,-0.047855347,0.019381966,-0.014001372,-0.0055163186,-0.07277101,0.12763618,-0.06552296,-0.08520007,-0.10662941,-0.10763975,0.010821513,0.017631162,0.046515003,-0.039625444,0.011330638,-0.0373979,0.06454249,-0.06763093,-0.07324026,-0.028273372,-0.07712973,0.037617616,0.0025708335,-0.0074249716,0.051060453,0.026412798,-0.007835206,-0.057053532,-0.024602033,-0.012636769,0.026585963,-0.03909339,0.032204807,-0.017104473,-0.027678508,-0.00013408254,-0.09172448,0.07611338,0.0055357213,0.08211034,-0.017288301,-0.03934434,0.011053343,-0.049189653,0.0040152473,-0.04177276,0.13139021,0.024711614,-0.043432467,0.07082569,0.14970927,0.0066222604,-0.048255697,0.015730985,-0.03062783,-0.0055642375,0.06492885,0.054901112,-0.0061091403,0.09143549,-0.03646504,-0.03123968,-0.07039422,0.13458338,-0.10147785,-0.040444113,-0.041914254,0.057311736,-0.010208692,-0.06770044,-0.013338212,-0.066554695,0.075148545,0.005465474,-0.099236965,0.013812179,0.038248483,-0.04104095,-0.019677063,-0.0023028823,-0.02494089,0.0067637824,-0.01181763,-0.07384849,0.02051421,0.037716288,0.01271574,0.04375762,0.09179838,-0.08763794,-0.017754281,0.027939014,0.040537678,-8.986819e-34,-0.0067444113,-0.06895422,0.017837338,-0.044837903,-0.03803552,0.057435058,-0.021880547,-0.07283938,-0.04058919,0.041552965,0.032718234,0.008585925,0.04113286,-0.068592876,0.0031338392,-0.015872722,0.03228357,0.07917076,-0.006723787,-0.035412345,0.046155747,0.059445377,0.11019837,0.049567785,0.00886818,0.019690314,0.050124247,0.080602854,0.04293363,-0.001478037,0.026801504,-0.042917985,-0.0050879,-0.008441932,-0.110006355,0.011843129,-0.021044146,0.035914008,0.035507925,0.032974195,0.015025301,0.0030868591,-0.01692962,0.10024715,0.097201265,0.01026457,-0.07307276,0.0039019627,0.0064462326,-0.02823963,0.07613723,0.026638389,-0.052162178,0.037492517,-0.00040622876,-0.0106304,0.0015696001,0.06340427,0.017461635,-0.052440614,-0.04634592,-0.07427069,-0.019420909,-0.041402046,0.08046903,0.05079444,0.01221319,0.087258674,0.0219298,0.026338428,0.08483976,0.039331242,0.0066421414,0.046372186,0.003355643,-0.0332751,0.0292808,-0.09446651,-0.030387083,-0.03775917,-0.037235335,0.01192946,-0.0035050851,-0.038222708,-0.052037243,-0.061936926,0.035213336,0.08157171,0.01591288,0.09807436,-0.018834798,-0.0037568905,-0.057489518,0.06478624,0.13320684,-4.5339394e-08,0.004503824,-0.04383185,-0.002707092,0.022263156,-0.0044757514,0.024594944,-0.0045092106,0.019191887,-0.0048460057,-0.013824905,-0.030510496,0.054577585,0.00020022705,0.052186795,0.05450383,-0.032954693,0.051711656,0.07399397,-0.0052969246,0.024258312,0.040287293,0.03307565,-0.06514627,-0.0037857604,-0.02558466,-0.09822024,-0.03729278,-0.019687988,0.014408437,-0.037082806,0.061509263,0.0031709608,0.014545753,-0.07698151,-0.055551413,-0.025739284,-0.017459963,-0.03946314,-0.0025638195,0.011920935,-0.016017435,-0.056237727,-0.065274104,0.035797056,-0.04260802,-0.008484099,0.04090269,-0.0066076145,0.046510357,0.040237468,0.056945987,-0.030989923,0.03301376,-0.09895088,-0.064026006,-0.038384717,-0.03781021,-0.03642333,-0.014982341,-0.04451969,0.053583726,-0.05170045,0.17064469,-0.030425051 +4.2.3.80,"The enzyme from Norway spruce produces longifolene as the main product (cf. EC 4.2.3.58, longifolene synthase). alpha-Longipinene constitutes about 15% of the total products.",384,0.99999994,0.029064067,-0.04567564,-0.04494498,0.007696925,0.11528421,0.06787869,-0.10315818,0.054979745,0.0015132526,0.019064683,0.007105095,-0.022502672,-0.10238733,-0.0228325,-0.04086666,0.0011100596,-0.10335892,0.0169991,-0.033104826,0.022352925,0.08227278,-0.00066314935,-0.00021203485,0.04895094,0.030725813,-0.022110008,-0.0026550991,-0.057619553,0.030720832,-0.07197651,0.021234844,-0.05891872,0.1245754,-0.058279905,-0.021892741,0.058627628,-0.061122496,-0.14828321,0.016248187,0.097230636,0.038365062,-0.0022603155,-0.014323766,-0.0054163435,-0.042901173,0.052085735,0.0044604726,0.015589359,0.015671529,0.07912028,-0.046781074,-0.0744821,-0.05781504,0.0122470865,0.0019915826,-0.06646404,-0.04143897,0.018482434,-0.01901303,0.085401855,0.07631277,0.028933058,-0.035781477,-0.06722116,0.004489747,0.010865245,-0.066261396,-0.020923829,-0.027406434,-0.02283634,-0.04546002,-0.01762873,-0.06941111,0.045317203,-0.006413472,0.034557063,-0.0040579517,-0.008134068,0.0742321,-0.09595745,0.06558156,-0.031360142,-0.062685624,0.050321877,0.057850085,0.044165917,0.009628663,0.063834436,0.028057871,0.017285254,0.05533019,-0.030784115,-0.046833534,-0.01215936,-0.072736286,0.03498096,-0.0014398925,0.056953505,-0.0152988285,-0.04958944,-0.03436822,0.00985253,0.01139008,-0.12657838,-0.13635546,0.015454876,-0.055728342,0.047413383,0.04178137,0.052872118,-0.03438465,0.028256029,-0.029093727,0.019758126,0.02123234,0.024047788,0.02170027,-0.11406036,-0.018898938,-0.035713356,-0.012878117,-0.0024589696,0.13392647,0.12198481,-0.005683942,0.08363351,-0.00089683937,-1.1472665e-34,-0.013598319,0.06084552,-0.052853674,0.035766244,-0.0841091,0.04277094,-0.07703231,0.063836016,-0.05827148,-0.023507064,-0.082238235,-0.034024317,0.003003582,0.061829947,0.018048743,-0.06519596,0.07364578,0.012969763,0.016179193,0.04633473,-0.018471606,0.017990105,-0.034489863,0.10394223,0.04626263,-0.05620682,0.024894405,0.05516043,-0.015594893,-0.046479248,0.042104818,-0.050947532,-0.011499583,-0.04028308,0.023706755,-0.06704241,-0.016251976,-0.054081194,-0.017949607,0.10271031,0.025949623,0.016420877,0.07688653,0.014183939,0.061289616,-0.024737034,-0.078804694,0.04925051,0.104465745,-0.017800713,0.014701213,0.074151196,0.05469342,-0.014311232,-0.035014916,0.036303744,-0.026880357,0.04013721,0.07141604,0.0650751,-0.070897534,0.12209013,0.013128332,-9.740531e-05,-0.06767934,0.047572143,-0.02604757,0.013153007,-0.011372066,0.042901903,0.039232995,-0.060468376,0.03688648,-0.0042413305,0.024371756,0.015279246,-0.10020055,0.08275317,0.017853362,-0.024563555,-0.071883194,0.009252154,-0.01177956,0.030270554,-0.036637947,-0.056881454,-0.067000024,-0.011515216,0.02147987,0.1014082,0.054568373,-0.067753,-0.028791105,-0.017946454,-0.0032144191,-4.699331e-36,0.049351722,-0.093527995,0.006401212,-0.052178912,-0.01638032,0.11110993,-0.06682377,0.009409933,-0.0245548,0.034358554,0.12095092,-0.054255538,0.017009377,-0.07279965,0.00015513535,0.0001337085,0.051904615,0.09088499,0.024345087,-0.05454759,0.048404604,0.00070474716,0.010589122,0.020002138,0.018078785,0.030954571,0.044168744,0.06823195,0.014541812,-0.024291078,-0.00606098,-0.06768356,-0.012352586,-0.033161014,-0.09117019,0.038091637,-0.013202937,0.013284883,0.044581693,-0.01818909,0.021885246,-0.08572712,-0.000997267,0.052601695,0.011688967,-0.022467293,-0.042076636,-0.0062028226,0.04119753,0.042386387,0.05924762,0.027303942,-0.0073368377,-0.009643805,-0.064357944,-0.050707854,-0.04219965,0.0133889625,-0.013691808,-0.03091816,-0.011448462,-0.019028433,0.0465109,-0.0702921,0.07591517,0.011083924,-0.058513697,0.038638864,0.07430898,0.018688018,0.050144862,0.014173877,0.008523437,0.092239514,-0.011167296,0.02549505,0.015680589,-0.06427905,0.060430862,-0.023845496,-0.0074045435,-0.0101148235,-0.01588521,-0.0052392855,-0.031863883,-0.04493057,0.077671714,0.037504166,0.015239872,0.0383795,-0.03579378,0.04879257,-0.048049327,-0.0024949976,0.09393996,-2.9156235e-08,0.034539547,-0.009004836,0.029316457,-0.05035341,0.01918981,-0.0077538313,0.006476617,0.050832484,-0.04037355,0.027534744,-0.06595004,0.08218979,-0.025008742,-0.0026668701,0.048846353,-0.10012129,-0.02843376,0.0137388585,-0.032584406,0.024632934,0.0027461213,0.029066073,-0.08395942,-0.015276282,-0.07730256,-0.11658052,0.028936613,-0.024121094,-0.018232344,0.007199009,0.04777527,0.04343961,-0.038363107,-0.013976862,-0.022350311,0.018734597,-0.030302754,-0.02115278,-0.0681508,0.053287167,-0.029001405,-0.013092613,-0.024281476,0.012394685,-0.025764342,-0.012911869,0.005489404,-0.027995097,0.0429316,0.060258806,0.061816182,-0.023972357,-0.017104937,-0.068195,-0.09215925,-0.0119238235,-0.026584204,-0.06974207,0.035134513,-0.061698172,0.0035359883,-0.075479075,0.21140414,0.06189406 +4.2.3.81,"The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (-)-exo-alpha-bergamotene (74%) there were (E)-nerolidol (10%), (Z)-alpha-bisabolene (6%), (E)-beta-farnesene (5%) and beta-sesquiphellandrene (1%).",384,0.99999994,0.00706668,-0.07303253,-0.086047135,0.06652759,0.044559296,0.034537897,-0.02491708,0.07659266,0.07920839,-0.049369458,0.034805834,-0.049894698,-0.009977933,-0.020306988,-0.022365639,0.024851844,-0.005923309,0.028977765,-0.02060694,0.029894471,0.024443995,-0.03493942,0.0076955366,-0.0043287734,0.109259926,0.054609384,0.0025210306,-0.03677925,0.03192637,-0.061532523,0.029319892,0.016015712,0.101961754,-0.07370045,0.047125023,-0.0024449169,-0.03527126,-0.0395529,0.05326057,0.04958067,0.025002444,0.026012687,0.03306339,-0.047910586,-0.106399894,-0.04363871,-0.023536915,0.066018134,0.011963708,0.061319023,-0.025337903,-0.13518295,-0.11886139,0.003304268,-0.0024657685,-0.05334991,0.0012556458,0.0063303607,-0.034076016,0.0648018,0.09784229,0.022185165,0.0125421565,0.0090567395,-0.0830544,0.00666997,-0.014188866,-0.036983855,0.0085281255,-0.04302645,-0.11565513,-0.034635186,-0.03023301,0.038889293,-0.03972455,0.02520248,0.060248107,-0.0026143054,0.043028582,-0.07534697,0.014163896,-0.007498002,0.011356262,0.05819303,0.040083725,0.10684528,-0.021975623,0.055373944,0.05195225,0.08062641,0.064183585,0.04112233,-0.05820735,-0.101603664,-0.012106338,0.08287895,-0.024066605,0.055772904,-0.017209167,-0.018440047,0.011291246,0.09020448,-0.042430412,-0.11790251,-0.03217247,0.030972302,0.00011223988,-0.027924381,-0.023953572,-0.032884136,-0.007162105,-0.03073271,0.07400381,-0.037025005,-0.06592313,0.0582501,0.03757302,-0.029177366,-0.040742468,0.01892545,-0.03391489,0.014604929,0.010552308,0.05514062,0.031465877,0.013584466,0.012145721,1.4575875e-33,0.057502538,0.07423211,0.016067602,0.061737143,-0.038999587,0.011248243,-0.047794808,0.06319309,-0.06300349,-0.028084133,-0.13037226,-0.08041381,0.015601298,0.038344093,0.09761462,-0.004062116,0.053661123,0.017559562,0.06850498,-0.07812531,0.010455947,-0.007871213,-0.04301556,-0.005360277,0.02364403,0.052630562,-0.0048378357,0.044670332,0.050179478,-0.06627268,0.009534599,-0.022603069,-0.06288781,-0.028106853,0.03575186,-0.016062764,-0.04672327,-0.013030052,-0.08159264,0.021483509,0.02011986,0.06644619,-0.048370834,0.037236735,0.026007516,-0.09293603,-0.058466773,0.033958513,0.17561835,-0.006243584,-0.024298497,0.011895235,0.084783606,0.018435994,-0.07293482,0.039217096,-0.06376759,0.04129987,0.048632335,0.042528845,-0.0017320407,-0.010661465,-0.0036681534,-0.05415417,0.059306704,0.09675085,-0.052996285,-0.05761465,-0.0582268,0.034006428,-0.018319108,-0.08698825,0.045542464,-0.030324083,0.02614384,0.007838033,-0.058446143,-0.05826135,0.062124774,-0.033229347,-0.026384631,-0.020013332,-0.00087688165,-0.04559696,-0.07204038,-0.03443821,0.021687955,0.011799791,0.01585163,0.06380937,0.035511483,-0.13328767,-0.097068556,-0.00085495296,-0.023800075,-2.1501562e-33,0.01619693,-0.06388044,-0.017459404,-0.08538078,-0.051215835,0.057919733,-0.0057367776,-0.04948543,-0.026752263,0.06719742,0.038239248,0.0013006754,0.06269288,-0.08173186,-0.05688914,-0.022004277,0.045380842,0.07752641,0.056399032,-0.0024280425,0.03253623,0.056195825,0.08010698,0.06569343,0.0111828465,0.013276591,0.034856662,-0.0113326,-0.0098512415,0.10224217,0.045104507,-0.05200624,0.014173944,-0.007998717,-0.103743576,0.0832735,-0.07067159,0.027132532,0.026977934,0.040014867,-0.052699834,-0.008616607,-0.05626316,0.090083845,0.10775711,-0.010551458,-0.13240345,-0.008839041,-0.042310107,-0.05143603,0.0054617254,0.022010136,-0.027716093,0.017739685,0.021935312,-0.005937143,-0.036312092,-0.026326574,-0.013658272,-0.09370435,-0.07599845,-0.0082987575,-0.029194422,-0.04548386,0.06050487,0.08360256,-0.037439022,0.0412773,0.019265292,-0.020296164,0.054457787,0.029629923,0.005776586,0.044298984,0.027642028,-0.057817273,0.056708094,-0.078480154,-0.014282855,-0.040877923,-0.049440503,-0.0027566992,0.0012692092,-0.020326303,-0.1026907,-0.053959202,0.0517318,0.1004187,0.031018618,0.07850004,-0.0419899,-0.00791998,0.024433259,0.090701625,0.12314944,-4.274363e-08,0.013515081,-0.012831079,0.06818059,0.029049557,-0.0395553,-0.020344986,0.0068367445,-0.018013034,0.0077413926,-0.008490666,-0.046327937,0.04338074,0.01750675,0.0054630325,0.09355608,-0.008674371,0.012594333,0.023382708,-0.018441405,0.0025326426,0.04168649,0.0040473593,-0.04154487,0.0019706332,0.076166525,-0.09309979,-0.021211963,-0.0052693365,-0.047783457,0.032118853,0.051082235,-0.053861402,0.025937537,-0.015975801,-0.053563923,0.046368096,-0.02584068,-0.037828427,-0.018757928,0.05020832,-0.03999329,-0.06629201,-0.06306418,0.016121853,-0.013140184,0.03563911,0.013173304,0.004460938,0.044307474,0.0068955473,0.04408672,-0.081117034,-0.0519863,-0.06465184,-0.05452157,-0.022382492,-0.015849939,0.01356046,-0.0015468815,-0.039016612,-0.04978739,0.0036036496,0.1367727,-0.036891114 +4.2.3.82,"The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (+)-alpha-santalene, (-)-beta-santalene and (-)-exo-alpha-bergamotene are formed with traces of (+)-epi-beta-santalene. See EC 4.2.3.83 [(-)-beta-santalene synthase], and EC 4.2.3.81 [(-)-exo-alpha-bergamotene synthase]. cf. EC 4.2.3.50 alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]",384,0.99999994,-0.037100915,-0.048983704,-0.09748331,0.047282513,0.06339618,0.054818396,-0.06830702,0.062292736,0.049749244,-0.03645095,-0.012730125,-0.027534988,-0.019177556,-0.02808003,-0.02184427,0.0091440575,-0.0729241,0.049537554,0.021797923,0.020719204,0.013146491,-0.048113104,-0.02191307,-0.007020293,0.09518041,0.04816917,-0.015618711,-0.031898916,0.0016023976,-0.09906576,0.002159637,0.009063984,0.061847046,-0.05820194,0.037512712,0.04012832,-0.025098473,-0.06523177,-0.017812882,0.02782414,0.08147071,0.02487333,0.00737637,-0.080927014,-0.044613346,-0.02204191,-0.035373215,0.03622719,0.014052861,-0.02062021,8.618834e-05,-0.13761806,-0.06765345,-0.030709412,-0.010909108,-0.025829216,0.0053519136,-0.0090791145,-0.0067555825,0.08967329,0.09930284,0.044874225,-0.023850566,-0.017582202,-0.036106326,0.016415844,0.005616793,-0.04663456,0.021569937,-0.034527842,-0.12999631,-0.033268236,-0.09188719,0.082514,-0.026370222,0.06413042,0.035715662,0.00658205,0.00813458,-0.001864908,0.03025017,-0.016488006,-0.018381523,0.014017747,0.045424722,0.10199593,-0.014066185,0.0044467305,0.073747516,0.08447165,0.05179764,0.01323002,-0.05608671,-0.05084628,0.02087939,0.066107504,0.018787568,0.07261911,0.016430253,-0.017027797,0.03700268,0.056900714,-0.020788476,-0.10634559,0.0053451722,0.012264096,-0.01289976,0.0099670645,-0.030996688,-0.04591119,-0.004696401,-0.02572371,0.054641288,-0.062421866,-0.06985366,0.09336598,0.01947726,-0.016962174,-0.05659949,0.060623445,-0.016360473,0.060102146,-0.007638703,0.08047629,0.03349088,0.0055589057,-0.05919861,3.6708156e-34,0.028427202,0.12944116,0.052381627,0.058210522,-0.014958625,0.018072965,-0.074442975,0.04468813,-0.060998537,-0.00065437955,-0.036591366,0.0009851493,0.052346654,-0.033541102,0.04993445,-0.008290206,0.023590554,0.0313784,0.047290217,-0.08833752,-0.03169052,-0.014221998,-0.06611743,-0.0061833085,-0.0003227323,0.013038286,-0.011454143,0.0012406743,0.11673851,-0.07007247,-0.026509892,-0.03236547,-0.07781544,0.021235932,0.059122648,-0.016653007,-0.033473454,-0.06734184,-0.054701682,0.011249735,0.101711065,0.03140208,-0.047535215,0.042084854,0.03187807,-0.089859374,-0.056321323,0.032653738,0.13026673,7.365726e-05,0.014992289,0.0058754566,0.038984135,0.04186494,-0.103157856,0.032877494,-0.041688107,0.04706213,0.059283003,0.049926344,0.043331057,0.03109875,-0.008795611,-0.05133581,0.025381459,0.06557884,-0.056202125,0.008493371,-0.059015106,0.048498247,-0.001519279,-0.0986299,0.11678563,0.0034545183,0.08324723,-0.0020571414,-0.10055977,0.0019878617,0.06158167,-0.054352563,-0.012694931,0.026920758,0.00043466804,-0.01782168,-0.049361795,-0.05847509,0.040113844,0.021432206,-0.036221415,0.08789887,0.09623913,-0.10116912,-0.09419684,0.038435906,-0.031357832,-1.0174707e-33,0.0647613,-0.058188893,-0.037236895,-0.1131736,-0.018812094,-0.008792725,0.021162143,-0.076761685,0.0052618245,0.028416427,0.096958436,-0.06607901,0.08584192,-0.06702918,-0.051581472,-0.07587369,0.061028115,0.06925345,0.010909405,-0.012115353,-0.005443292,0.012890332,0.086233296,0.08058563,0.015848938,-0.0031532478,0.05976963,0.046292864,0.014848199,0.090903565,0.050433364,-0.019751998,-0.045507804,-0.016572108,-0.099802636,0.06442811,-0.05390598,0.024018923,0.105690524,-0.0006920471,-0.05750247,-0.011864667,-0.057886265,0.06930808,0.15486304,0.041501265,-0.05056063,0.02662582,-0.0031605845,-0.027657973,0.02730566,0.029881129,-0.05566399,0.028208023,-0.04376431,0.019171283,-0.00893264,-0.019411247,0.025698727,-0.08663249,-0.03199212,-0.021385679,-0.012527282,-0.050493937,0.0021338274,0.049335077,0.0037896666,0.06603192,0.03601413,0.0020047557,0.041743986,0.04640076,0.012767281,0.034146182,-0.011133212,-0.012361298,0.067385964,-0.068112485,0.014470562,-0.10054409,-0.088516355,0.028841946,0.013242579,-0.002554085,-0.03573624,-0.0552821,0.03359885,0.11470872,0.026124954,0.07762374,0.0042726556,-0.008989639,-0.0024341461,0.118425295,0.08245742,-4.430591e-08,0.076972,-0.020511005,0.02789636,0.010871534,-0.007683352,-0.011466023,0.011947086,-0.039974365,0.0008066509,-0.03309897,-0.055013873,0.029368795,0.007983638,0.011159446,0.09210873,0.02042859,-0.036393587,0.01833886,-0.019411692,-0.040404435,0.020716304,-0.022165366,-0.054019853,0.0017318118,0.05892166,-0.08510298,0.006690049,0.028006053,-0.04124419,0.0066287266,0.05713255,0.0019172723,-0.027823484,0.014120489,-0.05538256,-0.00082489336,-0.008582007,-0.021277884,-0.03810567,0.025603557,-0.06036412,-0.0857516,-0.07542921,0.02449638,-0.021249615,0.028853836,-0.0069502117,0.0048772595,0.06561636,0.002092915,0.048749562,-0.040825084,-0.023909314,-0.06691752,-0.032389805,0.0025864122,-0.029367426,-0.013427296,-0.009873932,-0.034798022,-0.10645328,-0.040063914,0.12996939,0.013186232 +4.2.3.83,"The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (-)-beta-santalene (+)-alpha-santalene and (-)-exo-alpha-bergamotene are formed with traces of (+)-epi-beta-santalene. See EC 4.2.3.82 [(+)-alpha-santalene synthase], and EC 4.2.3.81 [(-)-exo-alpha-bergamotene synthase].",384,1.0,-0.01603325,-0.0668782,-0.0930263,0.071379796,0.046903312,0.06501876,-0.055271894,0.06338088,0.06474055,-0.036341086,0.008444296,-0.040852133,-0.040636867,-0.039233603,-0.0076691452,-8.688331e-05,-0.04356469,0.042838786,0.019239057,0.011309989,0.03066014,-0.057232257,-0.024150152,-0.0071966383,0.09084664,0.036638696,-0.008245845,-0.04541424,0.020034935,-0.10334879,0.020589985,-0.0055759195,0.084021084,-0.0494835,0.014816005,0.03927272,-0.019035554,-0.07177052,0.0060016173,0.04951166,0.07774339,0.012899184,-0.0027688607,-0.08451183,-0.057491664,-0.04422042,-0.038918808,0.05817156,0.022818172,-0.00059129164,-0.0012760222,-0.146687,-0.09137617,-0.021747282,-0.014833461,-0.025518063,0.040420722,-0.026383014,-0.032965865,0.09003929,0.10447203,0.03451456,-0.006428932,-0.012199483,-0.04109032,0.016451953,0.0079556,-0.029776415,0.020336758,-0.03846506,-0.123075135,-0.048473038,-0.10880651,0.06996667,-0.0319741,0.04412177,0.019013051,0.00037834144,0.02086743,-0.016725224,0.027497783,-0.0015481346,-0.0020057736,0.040588304,0.046139326,0.10355392,-0.018816456,-0.0057661333,0.08069442,0.09373715,0.045171753,-0.010860276,-0.05915453,-0.05248202,0.007475981,0.06686555,0.022963021,0.07371449,-0.0055426536,-0.023333047,0.008444818,0.06247388,-0.049445204,-0.11082914,-0.024132073,0.028967924,-0.020372575,-0.030103257,-0.016367475,-0.04868895,0.0024029943,-0.0326473,0.056733638,-0.056366287,-0.07371114,0.08570358,0.029932955,-0.032905478,-0.04409622,0.064111605,-0.0075132153,0.04300298,0.006804107,0.07537738,0.033892564,-0.0050844722,-0.019303812,2.8457966e-35,0.045505576,0.1051864,0.04628747,0.056805365,-0.010891985,0.017123561,-0.09058439,0.056950845,-0.053576548,-0.017731452,-0.0744012,-0.014618244,0.026112622,0.0014461663,0.078057595,-0.009484119,0.023520758,0.012286558,0.07207559,-0.07858317,-0.026944585,-0.016201973,-0.045372095,-0.006222365,0.015063299,0.031962723,-0.009856017,0.01880353,0.09563686,-0.059742473,0.007579965,-0.03136062,-0.07317133,0.021402366,0.031586424,0.001745821,-0.034365073,-0.050861694,-0.08418786,0.017436724,0.09353484,0.06644847,-0.039772715,0.026337875,0.025503743,-0.10725952,-0.05390947,0.035412785,0.1552364,0.01976196,-0.00059255137,0.0009347295,0.05357214,0.03933319,-0.08326333,0.026952619,-0.046625655,0.041217417,0.05000955,0.052354183,0.053715445,0.026879355,-0.0015873298,-0.060567763,0.030103263,0.09902361,-0.053622495,-0.009567863,-0.04949116,0.04200679,-0.017404245,-0.08200246,0.099240735,-0.018841757,0.06812393,-0.016879868,-0.11466909,-0.0044377893,0.057980385,-0.04949327,-0.032997064,0.0031361787,0.011592035,-0.017044472,-0.051296853,-0.035684448,0.031621173,0.03625084,0.002893536,0.048930176,0.08767812,-0.08401324,-0.098212875,0.036091108,9.281876e-05,-7.737868e-34,0.05000534,-0.08742425,-0.02383828,-0.086623475,-0.035892937,0.01733728,0.0027571355,-0.051671132,0.011032515,0.05679217,0.06812455,-0.04803656,0.08153474,-0.072168276,-0.029421559,-0.066596165,0.046239164,0.066283755,0.013276745,-0.04033598,0.003827018,0.02031887,0.08736469,0.07673741,0.022792498,-0.00493299,0.039722692,0.03564475,-0.011863342,0.089902736,0.051319633,-0.047030017,-0.029090486,0.00246629,-0.11449813,0.070896745,-0.057371896,0.053770088,0.078202985,0.02161038,-0.04812915,-0.009925553,-0.028217467,0.08523043,0.13205715,0.019774323,-0.098070085,0.03808779,-0.006263312,-0.051240493,0.0407894,0.020865628,-0.055817,0.016002312,-0.028397929,0.011874549,-0.018356886,-0.021254074,-0.007124307,-0.07995381,-0.055140935,-0.015091393,-0.02404366,-0.049031,0.030298851,0.0454181,-0.030870747,0.034942962,0.044696808,0.00032813265,0.059954975,0.030728733,-0.0050674933,0.04151343,0.016758267,-0.04185513,0.039753065,-0.07429541,0.0076436116,-0.085033186,-0.09579775,0.016363492,-0.003052992,-0.013874041,-0.0503473,-0.04822153,0.023074148,0.111364685,0.035068262,0.09530211,-0.014290763,0.003145017,0.0035768955,0.08703541,0.10183311,-4.413497e-08,0.060259894,-0.017390298,0.04454752,0.0352618,-0.0023982327,-0.020442912,0.003106273,-0.018998664,0.012327849,-0.014329328,-0.046704486,0.05102252,0.017810619,0.018265853,0.11340825,0.017684834,0.0074463375,0.0356394,-0.028814144,-0.03851485,0.021634772,-0.022107081,-0.047911424,-0.009200484,0.058443274,-0.094939314,-0.0011717193,0.015525506,-0.034830917,0.031022971,0.051258497,-0.015100854,-0.014762774,-0.0011899802,-0.08526073,0.018824056,-0.014699652,-0.009402737,-0.0372971,0.048190445,-0.054057,-0.09291352,-0.07597708,0.0036808327,-0.019648379,0.05635765,-0.0056749173,-7.943349e-05,0.043817583,0.011433231,0.04807504,-0.06798172,-0.022118162,-0.045238826,-0.055573974,-0.005784492,-0.027977483,-0.029097578,0.018623725,-0.03359647,-0.081865214,-0.024558248,0.1401637,0.013851696 +4.3.3.6,"The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. The enzyme complex is found in aerobic bacteria, archaea, fungi and plants.",384,1.0,-0.027096363,-0.03909461,-0.03943953,-0.09249884,0.037627693,0.03943016,-0.010284962,-0.010421671,0.024126811,0.037455272,0.021546502,-0.06205886,-0.093309775,0.027518801,-0.04503856,-0.007812045,-0.054686747,-0.018000768,-0.051850714,-0.074596025,0.09739529,0.09721466,-0.048151467,-0.03080963,0.018250402,-0.015458976,0.040849224,-0.014141005,0.025422476,-0.06363289,-0.07691605,-0.05222077,0.068262905,-0.04412722,0.017010216,0.110590406,-0.028717378,-0.05189018,0.07287245,0.04092471,-0.010932459,-0.0109621715,0.027123343,-0.07634609,-0.0713002,0.08118359,0.07493004,-0.007946966,0.0773864,-0.049198274,-0.02465993,-0.05079901,0.045498073,0.0350862,0.045299787,0.039554503,-0.05140941,-0.01965142,-0.060935345,0.030711668,0.019001551,0.022684682,0.015850166,-0.05571234,0.010937071,-0.04203927,0.013855186,-0.026673086,0.02570738,-0.07584759,-0.017616056,-0.08432311,-0.020703936,-0.00050759525,-0.050263427,-0.00024119888,-0.0027321246,-0.034664825,0.050759982,-0.01682948,0.06335792,0.049239162,0.08629847,0.030172108,-0.0034104509,0.009745146,0.013743251,0.018735273,0.0716986,-0.06203755,0.004282377,-0.04245686,-0.034004238,-0.072442755,0.0057742633,-0.0029774604,0.071035996,0.022140224,0.03712719,-0.04288882,0.033707842,0.013883957,0.018298194,-0.07448966,-0.049194336,0.05309061,0.022249535,0.11725136,0.038849305,0.03302804,-0.0009050064,0.07467754,0.037190665,-0.007379743,0.0059838444,-0.028310427,0.072488934,-0.03976064,-0.07709987,0.03125734,-0.012782512,-0.04656699,0.061953638,0.06963285,-0.072078876,0.05460757,-0.100710645,2.7809297e-34,0.052337766,-0.006388785,-0.0053011947,-0.040162828,-0.018168103,-0.00023079885,-0.03103304,-0.0021332835,0.046022143,-0.05234676,-0.15438706,-0.053324826,-0.026738524,-0.01219585,-0.060420677,0.052357934,-0.069115385,-0.038256977,0.028874084,0.048510626,0.051044933,0.05791915,-0.036356837,-0.0014512724,0.010609218,0.013554591,0.07278426,-0.09185463,0.021536037,-0.010177482,0.04630368,-0.1167517,-0.13719735,0.022473767,0.037154842,0.011487957,-0.053645246,-0.0010328848,-0.02190209,-0.0147564085,0.023917757,0.029428493,0.02347734,-0.04371753,0.03988559,-0.0010528578,0.0073903953,0.0362571,0.050262827,0.06775123,0.024967011,-0.003832445,0.00988598,-0.041093502,-0.06370557,0.010458739,0.017788246,0.0148848,0.030641574,0.12929535,-0.024618505,0.047511745,-0.023864957,0.05563271,0.037821926,0.06310884,-0.080933034,-0.07662304,0.08294902,0.08571986,-0.08782854,-0.08713824,0.058323245,0.04377752,-0.04612114,-0.104562856,-0.08501634,0.0067619267,-0.0277273,0.046498336,0.04408467,-0.081233025,-0.0019455984,0.045027964,-0.047569733,-0.06155587,0.02056936,-0.045003716,-0.040867094,-0.03709763,0.03386394,-0.033343628,0.0033490662,0.03606717,0.0009132377,-2.1519685e-33,0.15165822,-0.07889737,0.08637369,-0.055473756,-0.07154822,0.08164182,0.012928034,-0.05642324,-0.053626955,0.029370239,0.06789384,0.060439922,0.026121125,0.03014086,0.0017433481,0.0020074486,-0.0021650107,0.04606083,0.017427705,0.022076333,-0.027605992,0.024504801,0.057303667,-0.0014395374,0.08136147,-0.027610566,0.0323603,0.026474113,0.013198188,-0.029760338,-0.034795664,-0.0073454552,-0.044947688,-0.08129881,-0.045474842,-0.012181843,-0.0057246042,-0.06302681,-0.02971848,0.0021050277,0.051944926,0.049839184,0.016127821,0.050779223,-0.061265994,0.096373916,-0.10652687,-0.034434155,-0.04840235,-0.03658109,0.07025947,-0.042305168,-0.029101769,-0.032919783,0.028510354,0.052742556,0.024956826,0.08291474,-0.031416878,0.006004323,-0.056563307,-0.07106187,0.005352097,0.011502449,-0.00721789,0.053398572,0.005686875,0.03660584,-0.0010499932,-0.008312918,0.00737317,0.002832715,0.15828355,0.05819558,-0.021944093,-0.0035616073,-0.014713276,-0.05309633,0.046978645,-0.058883965,0.029463017,-0.031624306,-0.02939388,-0.05086609,0.078890696,-0.03899018,0.07727045,0.099543706,-0.05173221,0.010095,0.006468626,0.033545393,-0.027134988,0.024768183,0.11558155,-3.525991e-08,0.048566807,-0.03594834,0.055160053,-0.08483543,-0.041456353,0.07009905,0.057240464,0.07905145,0.010742633,0.023893615,0.025491517,0.060869824,-0.03461398,0.021663612,0.04157421,0.025830181,-0.093157046,0.02241213,-0.03288294,0.02321432,-0.040095523,-0.02249651,-0.09463944,0.07994217,-0.002325155,-0.019241866,0.055082906,0.025582254,0.0046144254,-0.027832832,0.0021440617,0.0353077,5.1946925e-05,-0.037835583,-0.10733813,0.039020248,-0.06962437,0.006108448,-0.06835964,-0.0072206818,-0.0077403127,-0.028174866,-0.04566454,-0.017845787,0.025598481,0.051081132,-0.044360552,0.09398657,-0.027273875,0.019556416,0.083929904,-0.022871755,0.05267142,-0.034283202,-0.099743575,-0.014389558,-0.052251235,-0.09737613,-0.007902584,0.019601475,-0.0066600353,0.036881555,0.0897087,-0.072872005 +5.1.3.24,Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation. This enzyme accelerates maturotation to the beta form via the open form (which also occurs as a slow spontaneous reaction). The open form is necessary for further metabolism by the bacteria.,384,1.0,-0.009881618,-0.11081289,-0.09943107,0.055927947,-0.009150588,0.027316025,0.0014307429,0.004896186,0.07290991,0.007686333,0.05713177,0.043689657,-0.09198599,0.037278876,-0.013166706,0.028808167,-0.102117725,0.029352084,-0.0104648145,0.05476047,0.031081198,-0.037702233,-0.056966256,-0.0141780265,-0.008787705,-0.030161843,0.0040991637,-0.05122873,0.051776826,-0.11038404,-0.011064016,-0.017018335,0.029959396,-0.072774835,0.089304365,0.062291976,-0.07423335,-0.06481044,-0.005456664,-0.04680176,0.052945137,-0.041011315,-0.027110916,0.0500367,-0.04408809,-0.00083316833,-0.0369638,-0.00183135,-0.010409163,0.016845547,-0.08490136,-0.05480546,-0.02267204,0.0346613,-0.009522614,0.04941346,-0.04751604,0.0028190867,-0.031447873,0.08979712,0.02381809,0.018377995,-0.009017234,-0.00071786175,0.035033185,-0.0273411,0.09198263,-0.039918754,0.021801502,-0.02878449,-0.04069661,-0.02083645,0.024031313,-0.027393973,-0.0053002327,-0.006125317,-0.00799725,-0.034019694,0.049180165,-0.037656806,0.03459305,0.03245945,-0.03831728,-0.007391808,0.027034933,0.05247018,0.020427536,-0.019010846,-0.03368024,0.048297904,0.06390575,-0.014869039,-0.03727244,-0.11923631,0.034491163,-0.00808426,0.058746867,-0.010447171,0.07614948,-0.024542332,0.038878642,0.047828246,-0.010788708,0.0032559268,-0.015561689,0.048452042,0.040842336,0.061192226,0.056927316,0.06866077,-0.015141539,0.004916381,0.027722303,0.08351632,-0.047820564,0.06864939,0.016772633,0.009283305,0.00788768,-0.0023155499,-0.016648317,-0.098839454,0.014329859,-0.02925103,-0.074575596,-0.015842758,-0.05520141,-2.5116802e-34,0.09901391,0.031264465,-0.065219775,-0.030375265,-0.031970534,-0.023006815,-0.116599314,-0.07530506,-0.05702234,-0.030146582,-0.03284514,-0.08148597,-0.016628696,0.10111106,0.014974573,0.015692264,-0.020336429,0.024924502,0.06877493,-0.066129304,0.025601435,0.08307738,-0.0018415222,-0.08768015,0.0019080942,0.017069826,-0.10359087,0.08979021,-0.042085625,0.037011724,0.022053955,-0.08522034,-0.10975467,0.047357157,0.06310378,0.02373609,0.013724659,-0.07028837,0.052500084,0.02134349,0.045097984,-0.00034394296,0.008593842,-0.040745173,0.024603354,-0.033686385,0.0015111091,0.1267716,-0.029428734,-0.06318218,-0.03270148,-0.06464098,0.015995696,-0.057693545,-0.016410178,0.028654182,-0.057196874,-0.10102777,-0.03234496,0.0582693,0.023676297,0.008942113,-0.03146747,0.04283414,0.013417087,-0.04609199,-0.10149132,-0.020132938,-0.022118427,0.007178019,-0.016396014,-0.0054719816,-0.042841036,-0.04025855,-0.0397211,-0.010317742,-0.02444023,0.0114415595,0.034060623,-0.0013245385,0.049001858,-0.009493051,-0.027346252,0.026858276,-0.0328975,0.05578013,0.039496504,-0.034058973,-0.045440122,0.041171726,0.028590742,-0.08548881,-0.07268566,0.037956223,0.015782164,-1.6702748e-33,0.09509845,-0.06798663,0.088311486,-0.09947075,-0.080843925,0.06506382,0.051427867,-0.055934995,-0.02367953,0.011943685,0.026847862,0.051154807,-0.032494538,-0.124801144,0.00045108932,-0.071988806,0.07391653,0.047913082,0.0027433475,-0.091010146,0.010015128,0.07808467,-0.023352291,-0.009987821,0.004793196,-0.006798943,-0.028556397,0.08866886,-0.022236666,0.087049864,-0.019828495,0.0020714605,-0.03828625,-0.055950224,0.0119072115,0.039317913,-0.027158508,0.03186837,0.004006015,-0.062816806,0.05847359,0.06289559,0.011232299,0.00884675,0.09192683,0.029481217,-0.09080273,0.031038055,0.01644259,0.068021506,0.063086495,-0.017629085,-0.01625258,0.014603905,-0.0018390308,0.050580982,-0.020037655,0.010132571,-0.08655319,-0.06922137,-0.09588626,-0.035373103,0.008062317,-0.035526697,0.097117335,0.012728472,0.0533215,0.06246122,0.086584575,-0.053791814,0.0034684078,0.04132877,-0.031286314,-0.019456524,-0.080348656,0.009203256,-0.10821856,-0.056008074,0.06911567,-0.026161416,-0.002620418,0.026178118,-0.06709248,-0.0719103,-0.013836899,-0.020535463,0.027307494,0.1399033,0.091656595,0.020924017,-0.02175951,-0.017218435,-0.039023463,0.015966678,0.036147643,-3.6867135e-08,0.027310982,-0.028780151,0.06959112,-0.010626916,-0.008181943,0.013812289,0.034615085,0.031604573,0.07057173,0.024997124,-0.03968254,0.12000316,0.04365051,-0.017618204,0.04126465,0.075254045,0.017175134,0.0069654877,-0.042717785,-0.048839763,-0.08826718,-0.04779929,-0.0070097125,0.09478422,-0.032225706,-0.08458353,0.031844087,0.05589711,-0.038283557,0.058930974,0.03100118,0.006425888,0.003956064,-0.050582673,-0.037835576,0.0724001,0.037845705,-0.05573352,0.026669715,0.06860595,0.03002889,0.046532743,-0.053190038,0.03960043,-0.013720926,-0.009663199,-0.035514306,0.06322076,-0.022660363,0.012939544,-0.005036122,0.0014149606,-0.06488282,-0.02267519,-0.088764004,-0.024307117,-0.0030092322,0.06273869,0.036970872,0.05830337,0.11389928,0.056521885,0.17297597,-0.04824811 +5.4.99.42,The enzyme specifically acts on uridine31 in tRNA. ,384,1.0,-0.03395414,-0.09024861,-0.14139879,-0.049697835,-0.0194545,-0.029165693,-0.014379381,0.026159866,-0.009048264,0.031728707,0.058279082,0.022602411,-0.081417635,0.085688725,-0.07391419,0.03599968,-0.04937102,0.009821717,0.06647206,-0.07620713,0.04850172,0.0985656,-0.0027336236,0.0016714651,0.0022609464,-0.0014333094,0.061916318,-0.04236126,-0.014080408,-0.09374645,-0.076376,-0.0184545,-0.010756,-0.031441864,0.028756492,0.042377573,-0.20318837,0.0027753324,0.05218319,0.023859493,0.05499379,-0.08771818,-0.0025731584,-0.04958177,-0.057427056,-0.066409595,0.020158434,0.06916324,0.009689495,0.08329048,-0.04936273,-0.0035798436,-0.011239741,0.05914719,0.005083131,0.045823064,-0.1108392,-0.017793756,-0.0076009138,0.028800543,0.020876998,0.003383321,0.023353232,-0.062599726,0.061853133,-0.06280634,-0.016618732,0.013022626,0.056817587,-0.08726174,0.005365906,-0.041972652,-0.00138368,0.009676721,-0.003580338,0.0016040716,-0.02968353,-0.019596506,-0.0066730347,0.01865618,0.0057692723,-0.054272383,0.04239355,0.022533996,0.122846335,0.016904175,0.022597715,0.049875032,0.011398946,0.021845782,0.09701888,0.05992621,-0.014668444,-0.0028017766,-0.038826745,0.0007814275,0.0119236875,0.06026182,-0.047574565,-0.038004056,-0.038324613,0.002293124,-0.057708,-0.043273382,-0.038902007,-0.024270235,0.08893192,0.045052934,0.0011675078,0.0018602563,-0.028787015,0.010810135,0.06828648,0.04200437,0.0058478247,0.05280857,0.07262994,-0.028070027,0.017473137,-0.0131613705,-0.050089803,0.026811484,0.014131569,0.010658723,-0.035728194,0.07039975,-0.0657273,-2.128097e-33,0.06750228,0.039875716,-0.058185387,0.013900271,0.05036381,0.037409026,-0.01782287,0.011367775,-0.020190446,-0.07631486,-0.112466484,-0.054008503,0.018591734,-0.057935927,-0.057848126,0.004540993,-0.02025471,-0.0009835407,0.05962772,-0.06534028,0.076090604,0.07082017,-0.06979696,0.031000575,-0.022695709,0.035407785,-0.0065567056,0.025233764,0.025927259,0.0008638936,0.007477237,-0.017196938,-0.06336768,-0.022664085,0.10011157,0.008669466,-0.0160589,0.036649838,-0.16127835,0.0209235,-0.063815944,0.014786335,-0.0070385616,-0.029515868,-0.009007351,-0.077724546,-0.021449665,0.10611781,-0.0047526737,0.07809759,0.04080082,-0.04148493,0.06543982,-0.0010082572,-0.045574058,0.015919382,-0.02225082,-0.04601738,0.05164789,0.0036173395,-0.00040559197,0.021894023,0.000520245,0.05712045,-0.01961899,-0.01928769,-0.04251126,-0.035022512,0.002083493,0.094468504,-0.0598509,-0.021342177,0.02947774,-0.026098408,0.029619241,-0.02661667,-0.10004724,-0.05119131,7.607125e-05,-0.016365273,0.028923329,-0.07466249,0.08445804,0.047902714,-0.042537738,-0.042961642,-0.02394547,-0.05279921,-0.032782663,-0.0069619366,0.0662554,-0.023247475,-0.09318388,0.015875261,0.09674503,1.098317e-33,0.1136985,-0.08444494,0.08706995,0.011339801,-0.045305487,0.04792009,0.029962456,-0.046812233,0.014090679,0.020142982,0.105022535,0.017256068,-0.016841646,-0.044435058,0.022327043,-0.02435971,0.015302276,0.012938109,-0.015527209,-0.035774704,-0.026727652,0.06114441,-0.05194861,0.03329596,0.00851321,0.019953178,0.07144131,0.05062985,0.043990906,0.018627385,-0.01363245,0.0009580041,-0.050022397,0.0100021735,-0.038484283,0.094071455,-0.014443044,-0.021639233,0.03483203,-0.041035924,0.061872937,-0.102115825,-0.04360119,0.10536856,-0.02156029,0.015611335,0.026398838,-0.001841456,-0.08925609,-0.07955626,0.11154214,0.028558431,0.055498004,0.0070001152,0.079594225,0.03186875,0.0070857634,-0.032986876,-0.040814247,0.03692569,0.023481524,0.011076455,-0.025651898,-0.025002174,0.011409891,-0.034894206,-0.06297536,0.082144916,0.060039014,0.0013574064,0.01826312,0.008276336,-0.0062529626,0.05838517,-0.02762506,-0.080414005,-0.042557452,-0.0056023058,0.06801022,-0.044863984,-0.04103434,-0.014950574,0.021629253,-0.070126586,0.06695092,-0.016346106,0.03321446,0.1306804,0.016323589,0.12145815,0.006018751,-0.003865963,-0.08416324,0.0077529806,0.0116781555,-1.743171e-08,0.0036622446,-0.04155482,0.027718749,-0.04080978,-0.004819793,0.058892373,0.020210927,0.119080804,0.029683167,0.02636594,-0.015521155,0.03180749,0.022963613,0.093625315,0.08161302,0.058373384,-0.045534685,-0.021570398,-0.041147485,-0.025369959,-0.11667572,0.009659872,-0.10454752,0.03499653,-0.005096894,-0.052314736,0.0006052549,0.089856714,-0.04640642,-0.05800147,0.033085596,-0.032892693,0.026050875,-0.04115825,-0.08937491,0.11446483,0.063951425,-0.043416,-0.022256792,0.020907927,-0.0071251574,-0.0059836223,-0.07373124,-0.021449229,-0.054060545,-0.0046534045,-0.030679246,-0.007185501,-0.02894669,0.015846064,0.037417743,0.05195122,0.0248395,-0.011880395,-0.03824108,0.020342097,0.042708214,-0.12529528,-0.015656712,-0.0056205066,0.058700897,0.02019441,0.1155167,-0.025285704 +5.4.99.43,The enzyme specifically acts on uridine2819 in 21S rRNA. ,384,0.99999994,-0.01961136,-0.043951374,-0.112618856,-0.016674407,-0.01871616,0.040931094,-0.0687098,0.023199497,0.0076920073,0.027055072,0.01550776,0.025564907,-0.0035614385,0.15073124,-0.05378751,0.0018721761,-0.11915068,0.003010444,0.05619186,-0.04042983,0.0578216,0.102338254,-0.037020706,0.005916639,0.0015281467,0.013920777,0.06282742,-0.018516103,-0.034893975,-0.078597054,0.03469025,-0.024206715,0.008617541,-0.014349054,0.046784077,0.009951344,-0.117156506,-0.007684404,0.036523674,0.016354192,0.042394545,-0.034126226,0.053901736,-0.011159007,-0.024122596,-0.023993,0.0065102093,0.04490898,0.03261111,0.028254975,-0.04924009,-0.04430204,0.014384092,0.03141799,0.11084405,0.041201632,-0.093108244,-0.059371356,-0.031853087,-0.04070185,0.048164334,-0.09146133,0.017336564,-0.08814817,-0.025555454,-0.028821023,-0.009667316,-0.019016808,0.014790131,-0.10399525,-0.04135877,-0.038708586,-0.022830136,0.02911212,-0.014510564,0.009644481,0.003220923,-0.039234668,-0.003557679,-0.035979256,0.015845781,-0.100078836,0.054665547,0.010836318,0.09207709,0.0039810217,0.10947599,0.036929406,0.05064799,-0.033147432,0.0769002,0.017593082,-0.011601878,0.008817512,-0.094167195,-0.047381017,0.0010301851,0.06196423,-0.04720856,-0.025220891,0.021282364,0.056515377,-0.06670923,-0.018646818,-0.03735134,0.0145379305,0.049602453,0.10858505,-0.017033631,-0.04560966,0.04331361,0.07580715,0.08132806,0.06853465,-0.0062038484,0.062972665,0.0140577955,-0.035405923,-0.045746725,0.012118214,-0.0684825,0.01869109,0.021388484,-0.0047491374,-0.0444422,0.062864624,-0.081177875,-5.9535304e-34,0.010046067,0.050955065,-0.056400593,0.0016075821,0.04164256,0.045402132,0.005589037,0.0135714095,0.006449759,-0.095663585,-0.08548143,-0.060401008,0.016815577,-0.04260827,-0.06093318,0.044483367,0.00081948785,-0.006341016,-0.024877707,-0.031513758,0.049703922,0.06698487,-0.07205126,-0.019277938,-0.001481147,0.01597839,0.006445633,-0.026482292,0.05449369,-0.02095074,-0.008778837,-0.043389767,-0.09541411,0.08138916,0.06729759,-0.015331297,-0.021417309,-0.028797096,-0.048259314,0.03274246,-0.022659194,0.030946141,-0.019529881,-0.019233176,0.036882408,-0.07425718,0.020213863,0.15060297,-0.02228535,0.14995839,0.028816363,0.015220648,0.07106076,-0.018873649,-0.07311063,-0.023072176,-0.05499057,-0.040416144,0.04446074,-0.02091595,0.03299399,-0.008751172,0.0010509116,0.021969892,0.03325537,0.03406206,-0.012416344,-0.0789791,0.027980462,0.11179024,-0.01762492,0.00692014,0.090926796,-0.020739855,0.0010348182,-0.02687851,-0.09071986,-0.018723603,0.057599235,0.025213879,-0.0014712483,-0.023629049,0.02731354,0.030063646,-0.024589136,-0.049851324,0.0012186707,-0.063931,-0.045102477,0.021431793,0.089605376,-0.08125749,-0.09347785,0.016451282,0.080860436,3.4091896e-34,0.13293403,-0.06965097,0.08729925,-0.008646165,0.013616889,0.008352675,0.019081905,-0.0045855585,0.0027365005,-0.05685735,0.11419062,0.009163751,0.06290531,-0.04530309,0.009131563,-0.038020935,0.018115586,0.016699007,0.008152291,-0.027044263,-0.0779853,0.077949606,-0.059812464,0.08045453,0.043506935,0.043106187,0.06248662,0.006701941,0.07731778,0.001553583,0.015717896,0.040181056,-0.0012812073,-0.036383826,-0.033856098,0.13052142,0.030997332,-0.03779086,0.003717312,-0.0485924,0.016600182,-0.044599183,-0.057706043,0.11308939,-0.021521172,0.023689887,0.003186761,0.01979725,-0.0360798,-0.093196645,0.027328748,-0.008055275,0.035757445,0.012364658,0.029925382,-0.017234487,-0.029754117,0.01682626,0.00031638832,0.00010666073,0.01930515,-0.035897356,-0.061953526,0.0061011063,-0.025485503,-0.008587438,-0.07841571,0.018549744,0.09577219,-0.031944577,0.04265595,-0.022686895,0.03254309,0.041489024,-5.3537533e-05,-0.09588658,-0.038872078,-0.0328045,0.0438214,-0.07519296,-0.048648607,-0.025476981,0.03925691,-0.034411106,0.03941678,-0.057939935,0.06101712,0.045677442,-0.056497447,0.045704696,-0.022033984,-0.036232747,-0.0882503,0.018545836,0.023065593,-1.9504988e-08,0.068125576,-0.07034151,0.010300311,-0.05712698,0.007281886,0.05353179,-0.008273001,0.12992412,0.020772247,0.042274777,0.016401941,-0.016438916,0.039122466,0.04524764,0.06637502,0.050674714,-0.03892215,-0.0017663178,-0.039641924,-0.008131511,-0.08089819,0.0003118612,-0.08209104,0.033480633,-0.001954979,-0.017181648,0.023604337,0.07772925,-0.046899777,-0.09288001,0.07158829,-0.08807332,0.055734742,0.0054120184,-0.07538916,0.08608805,0.0713789,-0.016622877,0.056484185,-0.03234477,-0.013684782,-0.04522858,-0.09194081,0.023836423,-0.05510229,-0.02931236,-0.054520503,-0.02527901,-0.045282546,-0.03613609,0.045996558,0.014322946,0.0504748,-0.038157083,-0.037225705,0.05225614,0.010733968,-0.09336466,0.02763635,0.033881914,0.08451246,0.0083919,0.10722338,-0.06613775 +5.4.99.44,The mitochondrial enzyme Pus2p is specific for position 27 or 28 in mitochondrial tRNA [1].,384,1.0,-0.07678068,-0.037499372,-0.05830713,-0.03718123,-0.014124416,0.019905739,-0.06285627,-0.006075377,-0.019675216,0.008068009,0.14087535,-0.021926953,0.001113819,-0.013515833,-0.0465173,-0.021505693,-0.08927579,-0.06991262,0.13850182,-0.027461221,0.015607504,0.037403863,0.009192027,-0.018401075,0.009480377,0.019271955,0.023606172,-0.022159597,0.042205032,-0.12186487,-0.054457832,-0.058588594,-0.016729904,0.024600387,-0.017541202,0.061222766,-0.102254786,-0.021342138,0.013008141,-0.022668062,0.05927836,-0.029541343,-0.00934398,-0.018201888,-0.031670753,-0.022063756,0.092735566,0.05682593,-0.032413807,0.017164925,0.03141272,-0.06386292,-0.017342253,0.061413407,0.03840428,0.05906437,-0.08804721,-0.028167974,-0.0393355,0.0285965,0.04696969,0.02665684,-0.03555733,-0.035229184,0.056996122,-0.06746476,0.0808211,-0.061984535,-0.006675464,-0.03299982,0.06440227,-0.011276898,0.0027015107,0.04058553,-0.01793542,0.05746327,-0.041638445,-0.06262856,-0.021948792,0.011388949,-0.0248289,-0.04414036,0.01895588,0.08157466,0.013369576,-0.019000312,-0.012690451,0.046246707,-0.04262806,0.029407496,0.058099803,-0.0014639678,-0.016400026,0.05468276,-0.0786065,0.099450424,0.02313345,0.12966336,-0.015444533,-0.07446619,9.471447e-05,0.08095981,-0.01018239,-0.050431557,0.0134049915,-0.04730665,0.00036147184,-0.026359953,0.0075670853,-0.0022475144,0.014004038,0.058023214,-0.0042298655,0.007093053,0.07791117,0.104103416,0.021841379,-0.031189604,0.040738087,0.009648025,-0.054317363,0.06766553,-0.028932557,0.01181847,-0.059963472,0.048873294,-0.07717067,-8.243031e-34,-0.030201668,-0.017599812,0.04853193,0.06254437,0.0034018857,-0.03412432,-0.08597208,-0.042041335,-0.008161663,-0.04860904,-0.084659696,-0.06308314,0.018996226,-0.060791995,0.012526256,-0.03075424,-0.035517566,0.03773615,0.06544537,-0.041398395,0.021145629,0.04349592,-0.06642111,-0.06658665,0.08555587,0.017249199,-0.0002092189,-0.00021137478,0.0824824,0.004320418,-0.041536972,-0.07395642,-0.07949662,-0.010339435,0.03070051,-0.041692145,-0.037586123,0.004733775,-0.089783214,0.05869581,0.028762307,0.011305784,-0.018094206,-0.023072025,0.053753607,-0.07951819,-0.010694406,0.013777961,-0.022044316,0.08119068,0.034468714,-0.016114965,0.054881804,0.02739059,0.014128523,0.0076399967,0.051620897,0.024151593,0.053723235,0.047823686,0.13945861,-0.009452136,0.071901456,-0.0003712313,0.08901305,-0.00031836168,-0.092914775,-0.06558476,-0.03209804,0.14034542,-0.07679367,-0.042548608,0.10907811,-0.06965019,0.046903826,-0.035247996,-0.06558509,0.0053019896,-0.008804176,0.015074556,-0.05424324,-0.0073856907,0.010935335,0.01232354,0.0037480583,-0.04696728,-0.0051992424,-0.00012973465,-0.027455747,0.011795493,0.08411231,0.009300963,-0.047256444,-0.0058415756,0.007383623,-8.649512e-34,0.015145744,-0.07432438,0.094971485,-0.08800715,-0.04267243,0.040528726,0.040859327,-0.0074873613,0.045959745,0.014319873,0.09944294,0.034248453,-0.058948796,-0.02382759,0.06944727,0.008322537,-0.0565804,0.08156207,-0.02868917,-0.0144122485,-0.006186082,0.083141714,0.0009531359,0.11928569,0.0069744545,-0.012150883,0.081350036,0.007576212,0.03586345,-0.019439759,-0.018723667,-0.0037026836,0.0034382392,0.08292042,-0.09862691,-0.0766033,-0.033237215,0.0062613916,0.044888813,0.020855052,0.012994638,0.020993955,-0.029325528,0.011252893,-0.024617177,0.01606934,-0.001853785,-0.037888907,-0.03377672,-0.107597835,0.08033424,0.017224766,-0.0056538535,0.030322926,0.052016087,0.032664273,-0.08719708,0.02335464,0.113435134,-0.03617044,-0.018636134,-0.023741191,-0.028592935,0.005534398,-0.014548897,0.009025624,-0.0726744,0.02385934,-0.06475162,0.010909421,-0.07221608,-0.009561866,-0.08732874,0.042012375,0.013301829,-0.041913908,0.028389215,0.043903492,0.08512723,-0.11892169,-0.06589099,-0.00027687472,-0.033003554,-0.028818112,0.035889696,-0.09136449,0.014552144,0.06888787,0.082043536,0.02264347,0.017805863,0.016075261,-0.045315277,-0.0188928,0.011539932,-2.0867963e-08,-0.017089369,-0.050409053,0.034303635,0.060577653,-0.009117668,0.08083717,-0.06383214,0.05659311,0.06838475,0.014432309,0.006585387,0.00783327,0.047137637,-0.0038246247,0.036658876,0.026973268,-0.022026537,-0.0036511691,-0.007496513,-0.026526073,-0.025581453,0.03575315,-0.04750374,0.07688296,0.017256629,0.036194917,-0.03104122,0.084689975,-0.03809541,-0.088421896,0.060172424,-0.051343214,-0.009060035,-0.04365995,-0.030154493,0.07803602,0.05356826,-0.05890871,-0.039232206,0.0870341,-0.013491405,-0.104852945,-0.043694675,-0.017517846,-0.051521163,0.035718888,0.031125389,0.06117932,-0.02898316,0.017221125,-0.031871404,-0.02077825,0.03642354,-0.075537354,-0.06863251,-0.002940422,-0.0038596953,-0.11165346,-0.10481422,-0.04470411,0.13887645,0.04143494,0.08248875,0.029940512 +5.5.1.18,"The carotenoid lycopene has the psi-end group at both ends. When acting on one end, this enzyme forms delta-carotene. When acting on both ends, it forms epsilon-carotene.",384,1.0,-0.08708047,-0.10408391,-0.040482674,-0.012028047,0.022666842,0.0613944,-0.0034249807,0.02853428,0.027094092,-0.043066222,0.09613821,-0.050746094,-0.06812098,0.026023217,0.0044234013,0.035025284,-0.13338271,-0.04521387,-0.064233154,-0.034371097,0.13808987,-0.0007226662,-0.0075787916,0.0319353,0.044070017,-0.012364938,0.03969051,-0.06941698,0.030836482,-0.05920604,0.0032405737,0.023799565,-0.096606284,-0.04419469,0.08487756,0.04658831,-0.052749638,-0.0011121823,-0.02376775,0.033373054,0.063336335,-0.0594709,-0.0022250777,0.063613296,-0.03762146,-0.0004593733,-0.04387485,0.048881937,0.018970875,0.046800267,-0.018076254,-0.07722393,-0.07306362,-0.021546993,-0.029773787,0.08475767,-0.11232,0.079919636,0.013361679,0.0016570904,0.10482792,0.051391505,-0.002532133,-0.018693315,0.12755997,-0.012697468,0.033969004,-0.061041657,0.0056972927,-0.036254123,0.017948274,-0.05225737,-0.03073168,0.032889597,0.05445961,-0.044278,-0.023527244,-0.009310425,0.0093399575,0.062478546,0.021946797,-0.0074986033,0.002861591,0.044894554,-0.011041926,-0.012078631,-0.035168815,0.045235544,0.02535593,-0.039118312,-0.018783387,-0.0055667944,-0.08301977,0.03496722,0.041635748,0.0027480721,0.028227102,-0.056060005,0.051531363,-0.05365816,0.010588808,0.013245456,-0.029509244,-0.04505108,-0.0051187947,0.010843518,0.038464237,0.03431699,-0.013080368,0.0070309793,0.047242574,0.02619619,0.114426136,-0.020450454,-0.041371536,0.032866742,-0.02124212,0.033434276,-0.07293017,0.03126795,-0.024230601,0.0326646,-0.0095096035,0.065418236,-0.043824974,0.08951802,-0.09937022,1.9263356e-35,0.071511306,0.002591894,0.054473978,-0.012582252,-0.037513163,0.021172298,-0.046775453,0.0028998763,-0.10834996,-0.011262422,-0.1156316,-0.046726465,-0.012642413,0.07053324,-0.06675011,0.0059646885,-0.021587128,0.0062888,-0.03147822,-0.045405287,0.01745391,0.09379417,-0.061911456,0.05122382,-0.046891384,0.027185198,0.009835832,0.071093746,-0.062115826,0.02666972,-0.03131369,-0.030401574,-0.034487713,0.0037420092,0.09565729,0.005318417,-0.029847104,-0.023875123,-0.013530163,0.012359107,-0.06208672,0.043333422,-0.004084491,0.0017683983,-0.04199971,-0.06102092,-0.0169081,0.007739694,0.053846147,0.0063251993,-0.00033533355,-0.035984483,0.030995093,-0.0014407341,-0.01472996,0.020810552,-0.017120881,0.05064664,-0.056638423,-0.050499387,-0.022438074,0.06208289,-0.039172187,-0.03949714,-0.020048942,0.04000768,-0.06918518,-0.034237377,0.052916013,0.018778557,-0.062492512,-0.043769725,0.018051406,0.03878054,0.06295816,-0.0024221926,-0.007650875,0.010983861,0.05275322,-0.0425275,-0.018220957,-0.016409881,0.088306196,-0.067395486,-0.058843903,-0.050408404,-0.0075842584,-0.115928955,0.010112163,0.05575853,-0.08533818,-0.016450217,0.040646497,0.00445042,-0.029174564,-1.9102167e-33,-0.025353314,-0.017830586,0.01643787,0.0036388247,0.04629496,0.021191549,0.010977695,-0.10896202,0.028692462,0.012979729,0.10460016,0.030624393,-0.00811203,-0.0015704418,0.031196639,0.0904705,0.025157463,0.054189354,0.032490432,0.021338627,-0.05785342,-0.005694481,-0.0152268605,0.07300191,0.059040777,0.022039091,-0.03238498,-0.013839493,0.030515332,0.020812687,0.040598813,-0.09890334,0.0069564395,-0.0010928777,-0.042431213,0.025244264,-0.025273746,0.008885077,-4.1797222e-05,0.020274494,-0.028755732,-0.023910562,0.105958536,0.010242603,0.011136932,-0.017958924,0.02727204,-0.12113619,-0.12220006,-0.0526677,0.02301582,0.0065269093,0.0497689,0.054654624,-0.0056770933,0.029292176,0.088975884,0.06788981,-0.021564234,0.019654917,-0.014793724,-0.09885339,0.03505519,-0.03827433,0.04751937,-0.07039041,0.031398814,0.06566836,0.07600913,-0.043975107,0.09968067,0.02569895,0.050124492,0.044962488,-0.061747707,-0.07376229,-0.0687031,-0.07247519,0.02282237,-0.0653174,0.03199691,0.039587803,0.026902951,-0.024441151,-0.044699848,-0.035454776,0.05082495,0.095804594,0.022101527,0.085953064,-0.04413522,-0.008352634,-0.059067294,0.004719486,0.16528066,-3.2143948e-08,0.022925436,0.040637504,0.008026222,-0.034915827,0.00880319,-0.031123182,-0.013492691,0.022317965,0.05842264,-0.004563577,-0.0053909756,0.04842441,0.027947914,-0.07711004,0.019033892,-0.019962206,-0.027396102,0.078737825,-0.016028618,0.080792956,-0.06652012,0.010752197,-0.12264404,-0.081366755,0.015722195,-0.07202906,-0.02511616,0.13220972,-0.0035337121,0.025382815,0.052009527,0.0022210442,-0.00070746517,-0.02999699,-0.15855502,0.07774261,0.023855409,0.007938874,-0.020207442,0.0833853,0.013249245,-0.02388441,-0.020220382,0.055925786,-0.046988152,-0.011517597,0.07620562,-0.0320214,-0.045002285,0.058117215,0.01895087,-0.035274893,-0.05920199,-0.029049624,-0.07458982,-0.016479269,-0.054825153,0.06837268,-0.0018326705,-0.09413071,-0.029326279,0.11681844,0.09552316,-0.045794606 +5.5.1.19,"The enzyme is a non-redox flavoprotein, containing FADH2 that is used for stabilization of a transition state. Lycopene has a psi-end group at both ends. When acting on one end, the enzyme forms gamma-carotene. When acting on both ends it forms beta-carotene. It also acts on neurosporene to give beta-zeacarotene. ",384,1.0,-0.08711792,-0.10903698,-0.103378505,0.02420508,0.083700314,0.05837739,-0.014939846,0.067460895,0.025922738,-0.048322905,0.030979227,0.033416513,-0.04667887,-0.006154004,-0.04236479,0.097805984,-0.083116576,-0.09100462,-0.0052254726,-0.044555973,0.057729784,0.008792786,0.009769136,0.01556671,0.06091757,-0.028342204,0.020562695,-0.069828324,0.013068716,-0.0060684527,0.06346718,-0.028406912,-0.08756938,0.0049800947,-0.039001532,0.08089081,-0.063228995,-0.058514003,-0.049785733,0.023019137,0.040136117,-0.048246782,-0.037148673,-0.0028334975,0.03700188,0.008050826,-0.05975337,0.02404834,-0.009651684,0.04907727,-0.04470627,-0.100051776,-0.07672472,0.03581872,0.020357596,0.08915465,-0.060916282,0.011100044,0.019345965,0.079410955,0.05557771,0.03674493,-0.023530424,-0.036748875,0.08548732,-0.045031436,-0.027234055,-0.07703261,0.035653662,-0.07392941,-0.026841504,-0.05626579,-0.014426448,0.020040104,0.029890768,-0.021494878,-0.037605204,0.026437217,0.026973205,0.02121104,0.0731699,-0.029324451,0.055613726,0.10152954,0.04565552,0.0017155372,-0.02942444,0.04211858,0.023995357,0.009261846,0.00052457064,0.021707984,-0.05997154,0.03889206,-0.0370656,0.019015798,0.0582061,-0.06777873,0.0036309864,-0.0008853123,-0.000595175,0.016907135,0.01590168,-0.034368496,-0.09212115,-0.0128553845,0.046866972,0.027714936,-0.026490945,-0.04464643,0.0414334,0.03505519,0.07505084,-0.046535883,-0.03784647,0.09917341,-0.0144595355,-0.025064342,-0.050264318,0.020020911,0.002435374,0.0729478,0.03805793,0.05597999,-0.016741142,0.028602177,-0.1263173,2.4779908e-33,0.050087675,0.05860751,-0.0053624082,0.013114037,-0.02286783,0.03239994,-0.07794397,0.0065483926,-0.01736696,-0.046061516,-0.015435081,-0.02982348,0.022547776,0.050876487,-0.0031440004,-0.001260426,0.0031068407,-0.016828187,0.051887445,-0.05392598,0.020827297,0.02948676,-0.041672796,0.066306606,-5.6792687e-05,0.02127826,-0.038143277,0.067331985,-0.020038625,0.032358065,0.024243183,-0.08176952,-0.08383878,0.017180683,0.046363074,0.0077260816,-0.09317269,-0.097160034,-0.024873968,0.04244598,-0.016256195,-0.0062824166,-0.031967644,-0.010807697,-0.020724794,-0.050490815,-0.026537566,0.049116533,-0.0020282548,0.019785345,0.06900984,-0.058187738,0.02435142,-0.016216358,-0.08390084,0.101753116,-0.016564103,0.0055309837,0.00820361,-0.035196934,-0.0006152026,0.00033383863,-0.023305269,0.02690825,-0.009226001,0.044751506,-0.07257213,-0.041576967,-0.02753671,0.03958029,-0.021851178,0.0053820875,0.13646807,-0.00933621,0.0798635,-0.018975558,-0.05928571,-0.02099523,0.023273377,-0.03951952,-0.0017298515,-0.05343397,0.020523433,-0.046943754,-0.023089174,-0.023068352,-0.0040111407,-0.08396318,0.03530096,0.031725463,0.0072973133,-0.054671723,-0.028576657,-0.0039317305,-0.0014122996,-1.9479493e-33,0.0018033542,-0.08601921,-0.0011184531,-0.0012628553,0.07587507,-0.0025758347,0.053857174,-0.13807209,0.061344516,-0.023176769,0.08194648,0.010768623,0.015993789,-0.023973009,0.050212983,0.05380727,-0.04096547,0.024679963,0.057142626,0.007909422,-0.023901815,0.0021863745,0.023171471,0.047312867,0.030521842,0.004728602,-0.032382,-0.015703714,0.13127843,0.038057618,-0.03635418,-0.063407935,0.004992536,-0.050395828,-0.029020354,0.07722694,-0.041968174,-0.030541439,0.013615671,0.027614707,0.003087784,-0.0066644633,0.05115066,0.0031895025,0.043457437,0.09334901,-0.011521159,-0.012317005,-0.03718478,-0.10899611,0.04565878,0.021473428,-0.022185655,0.055306356,-0.0013784,0.06461228,0.016977865,0.06588768,-0.0078128865,-0.0073322468,0.0011709273,-0.096951805,-0.0058046966,0.0107700545,0.057247855,0.0061010476,0.038100597,0.10908173,0.026934264,-0.024217412,0.17618468,0.01171226,0.07863056,0.0887839,-0.026110284,-0.048806,-0.055885967,-0.028210804,-0.0126861585,-0.071525015,0.015944952,0.014580078,-0.008966605,-0.027165102,-0.053005137,-0.080813594,-0.024921663,0.12344743,0.0085516125,0.0021486445,-0.046526,0.04543523,-0.041778315,0.03621241,0.15496977,-4.0081723e-08,0.014411663,-0.017719187,0.04398797,-0.027118519,0.03183245,-0.028317055,0.06930641,0.025750464,0.014990559,-0.0044497917,-0.052901518,0.07995485,-0.0032466105,-0.056580372,-0.024438206,0.01466635,0.0059808786,0.07689877,-0.023025773,0.02716721,-0.02543233,0.02766792,-0.07825644,-0.018675514,-0.050250962,-0.0553494,0.02015386,0.09714393,0.004935372,-0.06297872,0.027445098,0.08979241,0.044950552,-0.058446918,-0.19975567,0.07167415,0.026399452,-0.010655916,0.0147380065,0.07465339,0.0023045426,-0.005045652,-0.034566827,-0.0048091556,-0.069647424,0.02498176,0.044038657,-0.045961045,0.030078052,0.025757937,0.027940616,-0.04032027,-0.056041557,-0.016518107,-0.07573446,-0.0024034907,-0.035925973,0.011993539,0.032825932,-0.14355662,-0.047009982,0.085453354,0.16707613,-0.029425815 +5.3.2.3,"The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. Four moieties of alpha-D-rhamnose and two moities of 3-acetamido-3,6-dideoxy-alpha-D-galactose form the repeating unit of the glycan chain in the S-layer of the bacterium Aneurinibacillus thermoaerophilus.",384,1.0,-0.02672568,-0.08043206,-0.11454684,-0.028095197,-0.021729423,-0.00025301464,-0.028976435,0.0037561604,0.0321728,0.014963412,-0.0026587765,-0.0033634999,-0.016429197,0.01154504,-0.079590306,-0.031439442,-0.02772583,0.019962272,0.026625298,0.034686692,0.11574398,0.036351528,-0.018784469,-0.011348652,0.067242704,-0.027800336,0.064622864,-0.0841474,-0.046286676,-0.059476823,-0.02337787,-0.11275788,0.093101874,-0.00059942703,0.02379161,0.06410828,-0.009063056,0.013718852,0.07373129,0.055854067,-0.0012573216,0.041537177,0.0077726417,0.00504625,-0.04172074,0.013241153,-0.105658084,0.034941416,0.06073545,-0.005754467,0.022411853,-0.048075806,-0.053411778,-0.016543398,0.04447458,0.045104433,-0.024839817,-0.013618988,-0.00065103115,0.021693232,0.074616954,0.03289916,0.024415376,-0.0004330263,0.0059002526,-0.10085152,0.06938237,-0.027553257,-0.038716633,0.0097321,-0.053513948,-0.036382712,0.0182802,-0.04612443,0.033557896,0.050957244,-0.03382699,0.011394238,0.049237084,-0.047930118,0.043798354,-0.052653357,0.034059055,0.12301497,-0.018996807,-0.033741344,0.048401218,0.0004456337,0.05989872,0.05500635,0.011040334,-0.019687114,-0.0139114205,-0.042238884,-0.024707178,-0.017322209,0.05560141,-0.0017169418,0.035109743,-0.08127083,-0.03281705,0.017124586,-0.01176734,-0.0440494,-0.05715254,0.029860519,-0.08015965,0.044795062,0.107130446,0.015060174,-0.0032899268,0.052070353,0.03810356,-0.026822532,-0.07045028,0.030071212,-0.0411478,-0.059491485,-0.029097045,-0.04377891,0.05078123,0.001821263,0.024957497,0.06751071,0.0076599964,0.0005139556,0.03075936,9.903872e-34,0.098832615,0.1096407,-0.04253978,-0.0005426492,0.029049184,-0.0148153575,-0.09440837,-0.025091331,-0.037677865,0.0057671214,-0.09847645,-0.0741902,-0.04218252,0.08195483,-0.02831096,0.12801522,0.022872688,-0.022635693,0.021315057,0.01870307,-0.037069276,0.053769283,-0.017893817,0.008771051,0.050984208,0.06482796,-0.019736115,0.04993567,0.070708945,0.002858261,0.03756081,-0.112167746,-0.10387046,0.058971535,0.064111605,0.060373746,-0.04035475,-0.03010935,-0.013908146,0.036526397,0.025349882,-0.00079978135,0.023249501,-0.036362283,0.016635325,0.060102,0.024578962,0.042457297,0.01828424,0.070532314,5.4839493e-05,-0.016212918,0.11185634,0.0034211162,-0.05140112,0.006206002,-0.1087134,0.0534743,0.05551572,0.0519501,0.051662784,0.01822482,0.025620384,0.068618946,-0.0038718532,0.033299018,-0.021088026,0.0359791,0.035153605,0.0029798395,-0.05498927,-0.057308927,0.07852067,-0.00023033931,-0.035954997,-0.00758605,-0.020950457,-0.039589375,0.0028970037,-0.05562806,-0.0692041,0.027212262,0.0006771558,-0.055930197,-0.024211477,0.044903383,-0.02409231,-0.027187426,-0.01766992,0.07767556,-0.027911492,-0.069068424,-0.03095396,0.093398854,-0.011179067,-2.803596e-33,0.09722427,-0.14949416,0.07805944,-0.07539994,-0.07083746,0.07617073,0.002892692,0.04834865,0.004582238,-0.026030969,0.043737672,0.0043511833,-0.0719192,-0.101276904,0.0034774132,0.039804414,0.029885896,0.09508642,-0.06437495,-0.03505491,0.0081687225,0.011774499,-0.050708264,0.0054932022,-0.011104469,0.047542583,0.027099399,0.03866094,0.02591784,0.008946198,0.068044096,0.011897136,0.026320308,-0.048289165,-0.083778374,0.10160106,0.0076639294,0.014493193,0.0023657684,0.07227487,0.005577791,0.027320983,0.0072088414,0.014720922,0.09677093,0.09032646,-0.049315915,0.0080678025,0.053467274,-0.014760535,0.043250315,-0.08875812,0.03955375,0.01878804,-0.0018203411,0.042202827,-0.010066554,0.04987542,-0.0067493385,-0.030446827,-0.04334288,-0.040291324,0.033008583,-0.03600524,0.00795908,0.07300371,-0.016936107,0.037783258,0.05360616,0.0133059565,-0.00464884,-0.021226214,-0.046211354,0.03682663,0.00029598965,-0.07981505,-0.08761818,-0.070057824,0.016763235,-0.0012400426,0.01913161,0.06506447,0.031381823,0.026802389,-0.018185977,-0.06297608,0.078806005,0.122225195,-0.022659726,0.009267874,-0.04852441,0.026081743,-0.03990357,0.016084466,0.07097464,-4.2278693e-08,0.1440574,-0.05380702,0.04777494,-0.11791342,-0.0018748248,-0.011574588,-0.00434712,0.06674809,0.00487855,-0.09240436,-0.06582721,0.067234635,-0.02337038,-0.040179633,0.0028966179,-0.0057787136,-0.06416905,-0.0024557724,-0.0469148,0.0013480829,-0.08491081,0.0010966118,-0.10024555,0.0050648893,-0.01034953,-0.04443868,0.013324779,0.009136395,-0.034973733,0.036035586,-0.005293954,0.040323477,-0.053201523,-0.039652694,-0.11155314,-0.039162695,-0.040779065,-0.07193445,0.05087473,-0.024851464,0.03893987,-0.013636216,-0.013545494,0.031964675,-0.056706708,-0.02006612,-0.098355465,0.022721926,-0.042581476,0.061010588,-0.028078832,0.0017222071,-0.0883473,-0.054341048,-0.10255163,-0.111002535,-0.0001699573,-0.06954156,-0.052546445,-0.0540051,-0.0070502562,-0.027087849,0.13061684,-0.07211671 +1.1.1.315,"This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal [1] while the substrate is bound to the retinal-binding protein [4]. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol [2].",384,0.99999994,-0.06535618,-0.02605633,-0.043183595,0.006467567,0.0808688,0.038411167,0.021446893,0.01791005,0.0037923565,0.0019188836,0.011189124,-0.019773215,-0.051785022,0.036251463,-0.036568817,0.009915331,-0.04862,0.03910204,-0.03243188,-0.06736765,0.03671003,-0.059960444,-0.039050996,0.0064188535,0.0022582116,-0.022815155,0.10644214,-0.054694865,-0.047501583,-0.0030947295,-0.06878275,-0.08182565,-0.04803681,-0.08006324,-0.0061749876,0.0807455,0.03649884,-0.092636496,-0.023636734,0.035650283,-0.005750476,-0.0052775834,-0.04431882,-0.0055637276,0.046647646,-0.042346317,0.030476607,0.029674817,0.013406172,-0.042690776,-0.037180237,0.005570589,-0.10917579,0.060492236,0.05071083,0.10790448,-0.075912654,0.010914577,0.007932148,0.07090641,0.07245355,-0.079459585,0.0744623,-0.006262735,0.0032927769,-0.07548609,0.006316385,-0.07682028,0.00019526592,-0.004920625,-0.040035218,0.008055866,-0.008084598,-0.052622147,0.026257753,0.036634058,-0.00042343495,-0.00507088,0.059527364,-0.007773651,0.079162754,0.08176838,0.013285045,0.056321602,0.09855429,-0.026090968,0.038771912,-0.025555076,-0.013815354,0.030323066,0.058286767,0.042601664,-0.059074976,-0.044042785,-0.12801252,0.0048673563,-0.017181301,-0.037509676,-0.04629344,-0.035283085,-0.008444381,0.012326444,0.028651018,-0.14170304,-0.12857428,0.009157422,-0.046373468,0.1215829,-0.005228886,0.011419426,0.02352689,0.02019706,-0.029866237,0.053263217,0.045552436,0.16603562,-0.04761503,-0.066638134,0.02414489,0.06823818,-0.05602951,-0.005732287,0.07016798,0.044433802,-0.04266881,0.021736942,-0.05650388,-3.2323519e-34,0.05563751,0.0420553,-0.05160868,-0.01785434,0.025599701,0.042404898,-0.09449897,0.068723306,-0.10014688,-0.111114986,-0.00793943,-0.07677094,-0.00061901635,0.0017070405,-0.018507194,-0.065974,0.004771324,0.015816357,0.0383591,-0.08451825,-0.03950499,0.08474154,-0.058502205,0.011969928,-0.0029728608,0.08528164,-0.06935652,0.020943677,0.024624344,0.018287783,0.033567455,-0.013248983,-0.059786122,0.030148821,0.006939449,0.04556412,0.074855804,-0.058954034,0.007951675,-0.026217144,0.017379213,-0.0035132146,-0.019967908,-0.045630705,0.06465843,-0.047873825,-0.06959217,0.028123362,-0.017391546,0.006832982,-0.0007465795,0.022009032,0.053658504,-0.028524807,-0.09709419,-0.019854123,-0.0717831,0.030607684,0.054077446,-0.0056030927,0.0061444016,0.028694006,-0.01292918,0.120573565,0.0630709,0.043794982,0.04143608,-0.050365455,-0.04489921,0.052957304,-0.0098454105,0.029747661,0.069476984,-0.026068546,0.049986687,-0.013142941,-0.04519363,0.06279821,0.033322833,0.070106745,-0.04657111,0.026187593,-1.1604623e-06,-0.061791636,0.02130517,-0.04546031,0.04122736,0.027707048,0.043648615,-0.0016881658,0.105328135,-0.08943295,-0.018179052,0.003130975,0.031017173,-1.6711404e-33,0.061309736,-0.14085263,0.041274417,-0.083887,-0.079862215,0.061509047,0.02897895,-0.05985164,0.0053784545,-0.10198226,0.04171851,-0.052178297,0.014009514,0.0056493618,0.009900188,-0.06932662,-0.06197986,0.039880935,0.0006884297,0.0052908817,-0.014628167,-0.017171776,0.08356734,0.044633504,0.023978937,0.02233728,0.036662288,0.06483073,0.0021776287,0.05678698,-0.03436984,-0.03318403,-0.11465213,0.017272713,-0.017838527,0.003902554,-0.065797076,-0.0072786515,0.016823502,0.064163595,0.07569469,-0.062537275,-0.008343344,-0.009183705,-0.015357728,0.06315863,0.011912471,0.058157187,-0.011759573,-0.064408556,0.00031559262,0.030214598,-0.029409975,-0.02341253,-0.027660381,0.09595645,-0.016516903,0.032265823,0.042746503,0.0540708,-0.07859138,-0.06604034,-0.0041435915,0.059599373,0.0837698,0.09299486,0.042233333,0.0011974281,0.03889184,-0.047394264,0.13161306,-0.01602566,0.00090531894,0.08106036,-0.037879847,-0.071207106,0.011984624,0.02686538,-0.06198039,0.018179873,0.018125558,-0.06666831,-0.027712114,-0.018767102,0.0022497473,-0.03769296,0.01964998,0.08737362,0.06340237,-0.017062802,0.0076844366,0.008484808,-0.08884325,-0.0042345924,0.091467135,-3.5723136e-08,0.03533686,-0.046464026,0.06912867,-0.07708607,0.08649762,-0.019472998,-0.044318907,-0.001974061,-0.0029340112,-0.03192301,-0.024707925,0.013018651,-0.011627181,0.008852202,0.008134095,0.024494044,0.022964118,0.03293898,0.03525691,0.0071477056,-0.08458448,-0.079346135,-0.025386663,-0.009544699,-0.07048423,-0.03266189,0.0081658,0.032791477,-0.025075922,-0.008745061,0.0822392,-0.021942932,0.053981848,0.07441001,-0.06925459,-0.0056989877,0.011591171,0.017563548,-0.05837269,0.00014002857,-0.028492624,-0.011054505,0.008210518,-0.0035858583,-0.04142697,-0.0008781833,0.040684447,-0.03518482,0.0039135246,0.060848784,-0.07501973,-0.032742318,0.0073337187,-0.078803554,-0.114253916,-0.03723762,0.040064193,-0.008102772,-0.058879953,0.022434862,0.008718933,0.07933499,0.12247286,-0.010154388 +1.2.1.82,Neurosporaxanthin is responsible for the orange color of of Neurospora. 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+1.4.9.1,"Contains tryptophan tryptophylquinone (TTQ) cofactor. The enzyme oxidizes aliphatic monoamines and diamines, histamine and ethanolamine, but not secondary and tertiary amines, quaternary ammonium salts or aromatic amines.",384,1.0,0.032536633,-0.051993113,-0.062966816,-0.059872616,0.019683711,0.07015441,0.020582397,0.012224071,0.0009359601,0.025936604,0.033667594,-0.057152335,-0.0454143,0.13301657,-0.02170104,0.04089318,-0.0039979694,-0.06520879,0.06692855,-0.06669363,-0.004971739,0.10938061,0.05323437,0.00055548904,-0.033598084,0.09852639,-0.021035295,-0.0030055067,0.08374445,-0.036348138,-0.10143315,0.035326675,-0.029406035,-0.05154894,0.07903114,0.03359493,-0.034251858,-0.022765912,0.020773618,0.033748113,0.0147108715,0.029339174,-0.007485271,-0.021013629,0.041370537,-0.03394325,0.015325198,0.039241083,0.022892034,-0.01830328,0.007889396,-0.029776191,0.051538743,0.043264527,0.03348879,0.040661596,-0.051184326,0.0060847946,-0.0377552,0.08112585,-0.0043981657,0.09748107,-0.0020803327,-0.04340409,0.110606864,0.04594446,-0.030955449,-0.052569795,0.010909622,-0.04652107,-0.08253111,-0.10003437,-0.039261647,0.07474121,-0.053473007,0.028545875,0.030999487,-0.09049151,0.01270589,0.005707871,-0.045061216,-0.03188471,0.026316922,0.11289779,0.06857055,0.043039158,-0.08255228,0.02742617,0.018356415,-0.010965856,0.0280072,-0.026801497,-0.017201133,-0.07402374,0.03325724,-0.0017257637,-0.0058280574,-0.0128391655,-0.0027591886,-0.005689375,0.042277567,-0.023967477,-0.113320775,-0.07024684,-0.08989077,0.020035125,0.05265069,0.01193434,0.06699572,0.020090785,-0.04814803,0.060758475,0.06690112,-0.009374574,-0.026238974,0.006039357,0.052360088,-0.009498618,-0.015670849,-0.046123326,-7.899032e-05,-0.0014460876,0.0026848656,0.09274334,0.037612576,-0.022729825,-0.04237031,4.7917077e-33,0.11591602,0.05322868,0.06327057,-0.03659133,0.0013678682,0.07614414,0.0056717996,0.020634348,0.013118378,-0.018322693,-0.091571845,0.007177784,-0.016901068,0.0010328853,0.048699096,-0.011471519,-0.12000631,-0.0015377502,0.03927415,-0.048575446,-0.042738814,0.061671186,-0.026596226,0.028218683,-0.01053282,0.030051388,-0.041506894,-0.0073732655,0.005642587,-0.009320138,-0.06100601,-0.00024154405,-0.116963096,0.048547853,-0.04006664,0.007586035,-0.06636409,0.03448853,-0.117326014,0.050753515,-0.02542685,0.081089035,-0.018421026,-0.017649364,-0.023180561,-0.1377117,-0.020148639,0.025547806,0.025805147,0.010876051,0.0346669,-0.0048544346,-0.04493427,-0.034219388,-0.071948,-0.019091133,0.039704382,0.0033720026,0.055482257,0.09372651,-0.06757825,-0.056767184,-0.053377207,-0.0057579693,-0.0008770531,-0.011658757,-0.025792697,-0.090011515,0.025431123,0.053416103,-0.035549343,0.012325804,0.06771899,-0.008432424,0.031402394,-0.042797785,-0.032335866,0.06566905,0.027278839,-0.031405903,0.06951049,-0.1428923,0.02401963,0.027427025,-0.050185803,-0.013962233,0.075528555,-0.045113493,-0.01622324,0.019062787,0.004455735,-0.03835238,-0.014661237,-0.01662151,0.013973922,-5.579863e-33,0.04045599,-0.06742545,0.007107273,-0.06963081,-0.020675892,-0.04351784,0.0349564,-0.061037518,0.06383905,-0.069624715,0.11012401,-0.0467829,0.046298627,0.0049959538,0.0024382188,-0.026025256,-0.0033874493,0.12153757,0.011761735,-0.048811764,0.0051604104,0.05366591,-0.027903408,0.012809382,0.085517235,0.035379097,-0.022482134,0.018450584,0.052035473,0.038927585,0.0005243724,-0.021065515,-0.063163385,-0.025388917,0.028268047,0.030422743,-0.022330036,0.033601582,-0.05804263,0.007756404,0.04444324,0.022977436,0.014883181,0.06493219,-0.043299973,0.06780852,-0.12287499,-0.045162175,0.015379011,-0.013968685,0.06712034,-0.00994093,0.011267025,0.0068877386,0.036543366,0.031664845,-0.03917925,-0.03170344,-0.017752407,-0.023442136,-0.019464994,0.06596911,-0.031042889,-0.056714155,0.03200521,-0.037709523,0.001914977,0.059332244,0.066490866,-0.024392724,0.02995445,-0.02733434,0.13557994,0.06052179,-0.066919796,-0.07048242,-0.044959866,-0.018882671,0.06889764,-0.022325266,0.047131825,-0.02751225,0.0045422716,0.029802525,-0.034428492,0.02293622,-0.008585277,0.11812012,0.030268691,0.08477325,-0.014605906,0.019679561,-0.009000541,0.08215794,0.06489576,-3.820419e-08,0.024291763,-0.0979223,-0.034071177,-0.018449463,-0.059500817,0.05225695,0.033569273,0.0014998554,0.033966944,-0.047612652,0.07349949,0.046589755,-0.022286419,-0.013872266,-0.028475536,-0.018788187,-0.045584373,-0.009511113,-0.015484323,-0.07144675,-0.12866123,0.0050524287,-0.028229482,-0.035760254,-0.028782148,0.006150089,-0.010641209,0.073211834,0.032361627,-0.002618125,-0.040840026,0.02330423,-0.008437514,-0.09913983,-0.09759377,0.04152431,0.0380488,-0.011264018,-0.044969622,-0.04996388,-0.010526067,-0.04848279,-0.09476391,0.014412443,0.04576926,-0.05900971,0.028733123,-0.0028792059,0.048953317,-0.0743956,0.020556157,0.0042034728,0.009993344,-0.023961063,-0.097710796,0.005803545,-0.015254842,-0.06263518,-0.02823488,-0.12147244,0.05734374,0.032122057,0.22738898,0.0047186906 +1.4.9.2,"Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine ",384,1.0,-0.017174916,-0.052080754,-0.041759774,-0.06823409,0.05206598,0.0023404825,0.018028667,-0.0017713753,0.021046696,0.059155818,0.0033943872,0.041735962,-0.027182495,0.059469976,0.01311497,0.06630909,-0.040368963,-0.034850635,-0.015951592,0.058462817,0.023450503,0.06438878,-0.0011607476,-0.03757886,-0.07948232,0.06972176,0.012541315,0.02884525,0.065100975,-0.059917755,0.0048899218,0.023733366,-0.0023112274,0.032909274,-0.08423897,0.04696504,-0.047481135,0.008157323,-0.002550166,0.0023321102,0.041094147,0.038182538,-0.015124447,-0.062959656,-0.035443235,-0.08115823,-0.0072781737,0.021472791,-0.028857162,-0.06125234,-0.020156184,0.029066328,0.01947659,0.10512603,-0.05279242,0.017671552,-0.11727929,0.003908891,-0.044023056,-0.02954833,-0.090977535,0.009070136,-0.057036985,-0.048213694,0.0097594075,-0.034951545,0.012068988,-0.044477858,0.07523428,-0.04815087,-0.02387021,-0.03687069,0.024055075,-0.02012891,0.062199853,-0.011095816,0.020432498,-0.0037647765,0.007361715,-0.048095353,-0.08588465,-0.076430686,-0.025740687,-0.04604637,0.09647369,0.018588448,-0.11241418,0.04798669,0.09326538,0.015703337,-0.020914353,-0.0053245258,-0.0012656535,-0.033597436,-0.048201643,-0.04874039,0.061335895,0.060251705,-0.0060529397,0.03251892,0.0033869282,0.056624796,-0.18790437,-0.062078316,-0.077989414,-0.07984454,0.13307051,0.024769189,-0.10075252,-0.0012950149,-0.059035167,-0.052303534,0.10869621,0.039797667,-0.048839677,0.03589977,0.05296546,-0.11248148,-0.03718499,-0.13466872,-0.03273835,0.00013311552,0.021802159,-0.048237983,0.013477779,0.043123823,-0.02344021,1.631905e-33,0.00237813,0.049227174,0.0043102605,-0.03713875,-0.059084475,0.056512844,-0.03586133,0.08897936,0.05591902,-0.11165452,-0.019316822,0.009175039,0.017109053,0.058137212,-0.0027297765,-0.024680689,0.06827994,0.047736645,0.08256987,-0.09131574,0.024264183,0.0513696,-0.06330922,0.015906794,-0.036395513,-0.025621016,-0.012719789,0.055089623,-0.011846383,-0.018853355,0.10082968,-0.008880067,-0.032781225,0.06340274,-0.02068019,0.115872994,-0.11171239,0.0600445,-0.017111793,-0.058970097,-0.05112179,-0.0034575542,-0.026499165,0.10542243,-0.053452604,0.011386697,-0.07120748,-0.0038986523,-0.005882675,0.03210854,0.008689052,-0.011540386,0.049647667,0.0072418326,-0.057280757,0.07112371,0.034618374,-0.073627256,0.0055099116,0.013873392,0.017400606,0.031570937,-0.07609611,0.0212426,-0.032698855,-0.013883691,0.01588879,-0.015228563,0.039472185,0.06655032,-0.021938654,-0.008913551,0.0067047235,0.10248269,0.05235464,-0.020032596,-0.011611963,-0.03969232,0.046901368,0.023473907,0.01701877,-0.06014172,-0.015638985,0.11190636,-0.093025155,-0.023347186,0.038835946,-0.03616433,0.026907478,0.009529299,0.059091058,-0.121056296,-0.0037622543,0.00071494456,0.05151748,-3.953145e-33,0.059398524,0.005573887,0.034574278,0.026021136,0.054314014,0.0430002,0.041977756,-0.05635455,0.024231395,-0.0679343,0.09488769,0.01119639,0.01451549,0.04182706,0.02792253,0.022344125,0.05292603,-0.006898079,0.010312628,0.022717541,-0.02473518,0.053301845,-0.020473214,0.024016906,-0.017469704,0.0029217799,0.05600112,0.00264668,0.01273781,0.0017910857,-0.0145323,0.015658557,-0.025122475,-0.101091504,0.00121554,0.076713905,-0.0465791,-0.010761382,-0.10670334,-0.029834699,0.060092267,-0.0076395827,0.007170848,0.089794785,0.051040158,-0.003848218,-0.023072695,-0.051394906,-0.09496321,0.011067419,0.025069598,0.096941404,0.02318404,-0.051385384,0.15376477,0.042881753,-0.03220026,-0.121434994,0.013651132,-0.043667395,-0.0024405478,-0.028744224,-0.06377323,-0.035750568,-0.015428062,-0.06527424,0.02427878,0.027710095,0.06844717,0.00020962069,0.046588853,-0.04183236,0.08547561,0.040538862,-0.059486218,-0.07897093,-0.029020095,-0.022810508,-0.016800994,-0.039150465,-0.0030145901,-0.038264174,0.087608986,-0.072047606,-0.03085105,-0.013585145,-0.008005337,-0.04748645,-0.02343201,0.045766246,0.04307014,0.0066502523,0.04995482,0.043402605,0.010005752,-3.1314325e-08,0.035644647,-0.05930549,0.070727535,-0.020810677,-0.06171218,0.0063538756,0.05407982,-0.014506805,-0.019189665,0.015379342,0.030329265,0.056261577,0.056595907,-0.01725379,0.038414128,0.018805476,-0.06719884,0.0069248583,-0.061628934,-0.022600517,-0.11810302,0.026417412,-0.09293808,-0.0128825605,0.044018757,0.019789677,-0.07115391,-0.04619332,-0.005016035,-0.020129789,0.05179525,0.05990511,0.07556399,-0.0070138476,0.011422048,0.017152147,0.07365608,-0.0421775,-0.061146025,0.0053310012,0.06944561,0.030970573,-0.062397443,0.04349205,0.035594866,0.035569604,-0.014889187,-0.016755128,-0.0014510097,-0.038722347,0.059425417,0.03331346,0.07232842,-0.036356054,-0.073665045,-0.043116383,-0.06570134,-0.051422033,-0.008178787,-0.02843703,0.06960556,-0.0052292086,0.06151235,0.06455241 +1.6.5.10,"A flavoprotein [1, 2]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [3]. +Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [1].",384,1.0,-0.036486022,-0.05043249,-0.118299074,-0.013584096,-0.0033396266,0.018837932,-0.042049594,0.029852724,0.038947206,-0.008247837,0.0037132355,0.013161914,-0.07774266,0.101483114,-0.04012352,0.007873365,-0.010766771,-0.01806123,0.028351784,-0.014335958,-0.021988574,-0.031149454,-0.002335038,-0.09835544,0.01967452,-0.02771117,0.014156276,0.015762059,-0.066827185,-0.07358291,0.002031926,0.0058516823,0.036772586,-0.02922718,-0.07322926,0.019737516,-0.03971556,-0.003171588,0.029509384,0.023499478,0.0030576307,-0.018675005,-0.011789107,0.003362804,0.043835603,-0.05591673,-0.051265858,0.08266947,0.06556965,0.07283961,-0.09377733,0.011351819,-0.01168896,0.06285826,0.03603927,-0.044125862,0.013934512,-0.06555747,0.0032369792,-0.039631534,-0.0043424014,-0.077241704,0.04092028,0.011175111,0.0013767632,-0.087404124,-0.032682233,-0.04833025,0.015811514,-0.061694965,-0.010032618,-0.042626984,0.0007061679,-0.022693118,-0.013798055,0.08420047,-0.094226815,-0.006974089,0.10216701,0.002995783,0.02821612,-0.0397871,0.016200561,0.1297042,0.07456489,0.0687097,-0.08377829,0.045530595,-0.026081847,0.09651919,0.008021371,-0.026136287,0.050976798,-0.030587984,-0.044748604,0.011337359,0.028425239,-0.017669804,-0.107099354,-0.008638876,0.011143977,-0.0034380883,-0.022186974,-0.07620409,-0.07942835,0.05250754,0.023654731,0.09369869,-0.021341182,-0.05030189,-0.08195109,-0.0504567,0.0037193296,-0.050135333,-0.018639516,0.078047425,0.06606842,-0.065472044,-0.076384716,-0.016873483,-0.043589033,0.059897345,0.091825485,-0.00033215265,0.04657859,0.04109314,-0.06822091,4.59381e-33,0.078184895,0.051740408,-0.050501827,-0.0037247788,0.031329162,0.01991629,-0.059515204,0.05567183,0.0027669182,-0.09837867,-0.043079596,-0.0284705,0.01125957,-0.05843208,0.03206236,0.015526657,0.010907776,-0.06964585,0.03195751,-0.061051387,0.07303574,0.018176299,-0.036549434,0.016170835,0.04159801,-0.0065116147,-0.08411396,0.052663222,-0.00029545836,0.032249056,0.034209814,-0.08250929,-0.05499929,0.024992777,0.043414645,-0.014079464,-0.061488267,-0.043176256,-0.08901504,0.05320476,-0.019566815,-0.0026680855,-0.04569942,-0.022348838,0.060896114,-0.06597389,-0.067355104,0.105568774,0.0034772933,0.05621763,0.043382052,-0.032897834,0.088898145,-0.05099488,-0.043115973,0.04398515,0.030542519,0.02901642,0.00684901,0.04068627,0.0221937,0.054430436,-0.02107153,0.03332549,-0.07826344,-0.027660334,-0.04954403,-0.10422203,-0.04888015,0.109387055,0.01441695,0.019197347,0.057291333,0.023092309,0.028999627,-0.060023203,-0.06376819,0.0030705235,0.024540303,-0.016899629,0.019055542,-0.079599,-0.053904343,0.032297324,-0.057584077,0.05745521,0.053364046,-0.080839,0.015505083,-0.029785154,0.07262321,-0.054341067,-0.052905273,-0.016390914,0.112717204,-4.6413278e-33,0.073939465,-0.07740324,0.060579974,-0.011474115,-0.022037527,0.109331876,0.026512148,-0.08379731,0.084034935,-0.07365201,0.048234142,-0.00015706317,0.034256164,-0.024629077,0.020710615,-0.012590348,-0.011012384,0.020656165,0.016164884,-0.054855302,-0.050796438,0.025651883,0.067439996,0.014440813,0.03598658,-0.007808654,-0.030648217,0.016257213,0.007266725,0.08989596,-0.0648529,0.04185216,-0.036622666,-0.06256247,0.031619154,0.0110096345,-0.06642004,0.033546187,0.017385928,0.04869986,0.015990963,0.0014963838,-0.05010697,0.0738439,0.058390893,0.09789236,-0.049414795,0.055555433,0.051801745,-0.037442286,0.027105886,0.030205734,-0.023799753,0.069672726,0.10321749,0.09996016,0.06913293,-0.034747288,0.032807097,0.0012930139,-0.07009975,-0.057943616,0.014098833,0.012951038,0.06466408,0.037324607,-0.020395147,0.10423505,0.06069504,-0.06680733,0.10925124,-0.066535,0.06734668,0.104706764,0.005006377,-0.008091838,0.026519522,0.005770665,0.011859834,-0.03286493,-0.019939499,0.006139707,-0.00951226,-0.0022662687,-0.0148044005,-0.09090327,-0.0044544246,0.0292653,-0.011653368,0.031336103,-1.7304063e-05,0.07477869,-0.01604976,-0.02226761,0.04727366,-4.2145466e-08,0.041466918,-0.043757483,0.004372093,-0.027422745,0.044145066,0.019137708,-0.035254396,-0.0723925,0.052509885,0.027719887,-0.022888185,0.16511045,0.015172895,-0.0049889633,0.05608128,0.022302307,0.0071854666,-0.000109890665,-0.023536073,-0.011829503,-0.06882314,-0.00065892155,-0.082973756,-0.025189102,-0.045060404,-0.052207496,-0.019677665,-0.07123521,0.044705942,0.0013821351,-0.0311737,0.026154032,0.04728618,-0.071022466,-0.08777867,0.052735865,-0.018286403,0.0019782872,0.005769614,0.035990145,0.010497078,-0.05649405,-0.04860458,-0.038987502,-0.024831116,0.0047461246,0.058791447,0.010508794,-0.05449107,-0.019288965,-0.0032274767,0.032535363,0.0564625,-0.040261555,-0.07814232,0.014206145,-0.0067411996,-0.08659861,0.012187557,-0.1446224,0.016943116,0.014124254,0.15080974,0.00427999 +1.13.11.59,"It is assumed that 3-methylbut-2-enal is formed. The enzyme cannot cleave the saturated 3',4'-bond of gamma-carotene which implies that a 3',4'-double bond is neccessary for this reaction.",384,1.0,-0.06332855,-0.071884446,-0.0813177,-0.055775058,-0.038507223,0.017909644,-0.043360487,0.0515788,-0.015310831,-0.0016735239,0.067171946,-0.10657226,-0.030547928,0.014359946,0.07448807,0.058512073,-0.08298714,-0.026765147,0.0139339715,-0.026787098,0.08547125,-0.046128914,0.025105013,-0.0039828164,0.038367122,0.023786804,0.052938543,-0.0767027,0.025907718,-0.048594907,-0.010108195,-0.040540904,-0.0409685,-0.02597841,0.05490109,0.013098539,-0.069928065,-0.07662031,-0.04972091,0.015691074,0.032987397,0.0070870887,-0.0668651,-0.05139372,-0.025656527,-0.06109189,-0.016763426,-0.027195714,0.04787458,-0.038395412,-0.00877927,-0.070115216,-0.017249048,-0.042860527,0.03476867,0.049485438,-0.0643337,0.021854492,-0.028013682,0.0633068,0.14715916,0.015081755,-0.04214979,-0.032805298,0.110783115,-0.035975497,0.001996434,-0.0761406,-0.07604118,-0.012260266,-0.049418893,-0.06101041,-0.10908225,-0.014737208,0.0072600017,-0.02722296,0.029876534,-0.013855019,0.0045771077,-0.03247148,0.023872986,-0.040776514,0.050299678,0.05417399,0.06979523,0.013768821,-0.017631423,0.031508174,0.06336461,0.07003586,0.0027726414,-0.00047899262,-0.031295083,0.065833434,0.0077478327,0.070039324,0.0060899374,-0.03662022,0.025235843,0.034713272,0.048788574,0.083365075,-0.09228684,-0.042089093,-0.0097393505,0.025050346,0.010652249,0.083068445,-0.028180772,0.017681278,0.058092624,-0.028135002,0.12968524,0.0056813713,-0.0915619,0.12314184,0.011202991,-0.053929657,-0.039445065,-0.07881176,0.026816916,0.049093675,0.037333585,0.02169339,-0.0155830085,-0.016788173,-0.10688094,-4.8490666e-34,0.047238857,0.103526436,0.043340392,0.026200704,-0.05000078,0.05516149,-0.07760365,0.022716654,-0.022004452,-0.058441013,-0.04652427,-0.10839092,0.08991201,0.055576116,-0.07343805,-0.010004719,0.035943758,0.037420396,0.015256754,-0.009962138,-0.032178376,0.08271384,-0.037159283,0.011599141,-0.039669745,-0.013546249,0.01186302,0.026791364,0.10007033,0.0006469124,0.023327261,-0.061843835,-0.08090774,0.01943945,0.104022145,0.021042267,-0.017331852,0.007084118,-0.03843003,0.08661857,0.072672896,0.0401501,-0.0015271578,-0.051930144,0.017397849,-0.031201651,0.020136047,0.033914253,0.028705478,0.0068702367,0.031199627,0.03005243,0.020320876,-0.018597294,-0.026447231,0.09534774,0.05043668,0.018311197,0.04462335,0.015150851,-0.055076923,0.011968696,-0.012782387,0.03714144,-0.040204566,0.038008332,-0.07961895,-0.057590693,-0.042026654,0.006356629,-0.046077363,0.0022214474,0.089691594,-0.01626947,0.0661754,-0.07904434,-0.028228216,0.010616544,0.01533363,-0.022676619,-0.034292728,0.00044059916,0.06704028,-0.023259448,-0.055657636,-0.06846426,-0.03668916,-0.041913006,0.039581917,0.13130805,0.030978583,-0.018178552,-0.038128864,-0.019282497,0.035383154,-6.618001e-34,0.059950136,-0.039936155,0.023663078,-0.0684985,0.0067146597,0.027824095,-0.039471403,-0.08742817,-0.0035270122,-0.015585392,0.12317051,0.09168049,0.062135357,-0.051314186,0.05577176,0.022584308,0.015036315,0.064244285,-0.037403036,-0.050047442,0.035247803,0.05064733,-0.010884991,0.09474347,0.016339874,0.06567966,-0.022053314,-0.02194981,0.06601926,0.029983914,-0.012232773,-0.07348386,-0.04787003,0.022662485,-0.018947227,0.04723398,0.0066441,-0.025177736,-0.028440664,0.08256749,-0.11051564,0.028746746,0.011952774,0.047917668,0.024487041,0.06450922,0.027634442,-0.039434057,-0.032616004,-0.015414172,0.06321016,-0.058621652,-0.0026146346,-0.007586609,0.046961408,-0.03742412,0.0052001853,-0.048447393,-0.0014054783,-0.006395902,0.010338983,-0.007829093,0.057279296,-0.10699108,0.046981845,-0.016216591,-0.06749307,0.09078264,0.060463633,-0.08172044,0.0316964,0.008049426,-0.01831659,0.03489402,0.013487384,-0.022305401,-0.07934155,-0.03480221,0.0066972207,-0.09918917,-0.0629068,0.021944622,0.056505334,-0.06269163,-0.027351486,-0.10726387,0.028526638,0.10287659,-0.016548151,-0.031605653,-0.069450445,0.044690497,0.03361399,0.17461929,0.12424362,-3.839804e-08,0.02050139,-0.06393124,-0.054407466,-0.003141064,-0.08934169,-0.0010478501,-0.006608878,0.013116807,0.099089004,-0.035022933,-0.05444985,0.048641875,0.021954672,0.0637787,0.008398301,-0.03778421,-0.00030383866,-0.031324558,-0.064990535,-0.051634315,-0.056844003,-0.008265702,-0.09815392,0.009119708,0.025623495,-0.047208887,-0.05453658,0.06538739,-0.009743525,0.01483333,0.033816293,0.03014735,-0.0250808,-0.01905338,-0.09395685,-0.021681225,0.029998934,0.002858591,0.03227827,0.06020511,0.014168926,-0.01019721,-0.039665923,0.04097776,-0.05483698,0.01628247,-0.022139814,0.037205927,-0.02444032,0.00022100407,-0.0054765292,-0.00072745,-0.01158173,-0.026927587,-0.053450793,0.016414948,-0.014255101,0.031133834,0.027655827,-0.051061355,0.00056283025,0.0058581196,0.13182954,0.0033993751 +1.13.12.19,"This is one of two simultaneous reactions catalysed by the enzyme, which is responsible for ethene production in bacteria of the Pseudomonas syringae group. In the other reaction [EC 1.14.20.7, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)] the enzyme catalyses the mono-oxygenation of both 2-oxoglutarate and L-arginine, forming succinate, carbon dioxide and 5-hydroxy-L-arginine, which is subsequently cleaved into guanidine and (S)-1-pyrroline-5-carboxylate.The enzymes catalyse two cycles of the ethene-forming reaction for each cycle of the succinate-forming reaction, so that the stoichiometry of the products ethene and succinate is 2:1.",384,1.0,-0.071637176,-0.049118027,-0.05641843,0.016699787,0.09423152,0.027087454,-0.03973107,0.049523763,0.012302688,0.02472521,0.030803332,-0.09486257,-0.017341595,-0.0043094703,-0.10606282,0.014274872,-0.12076239,-0.057154715,-0.0050126207,-0.025140421,0.12542601,0.024312513,-0.08702487,-0.009501619,0.10412401,0.05042027,0.025817659,-0.060873296,-0.06957108,-0.07450153,0.01957494,-0.10219163,0.02912389,-0.04891177,0.03864143,0.024739211,-0.021947335,-0.04034655,0.112505764,0.0014930943,-0.028332667,-0.02664844,-0.04274672,-0.05366901,-0.022680104,0.017347362,0.03245107,0.0030561711,0.0016260631,-0.06852329,0.0030859252,-0.056944817,-0.07212494,-0.015898552,0.0026664587,0.027856767,-0.038216084,-0.041482,-0.046063974,0.0017591737,0.01819983,-0.011049415,-0.06475205,0.025714107,-0.023784643,-0.04670504,0.05234,-0.06318079,0.003567159,-0.030166166,-0.04981555,-0.044392325,0.04024574,0.032796383,0.022634894,0.0010881051,0.031783782,-0.09271456,0.022801034,0.022768648,0.055357393,0.02969144,0.0045322855,0.01110518,0.016791482,-0.044317294,0.06920848,0.028481727,0.075704254,0.034206346,0.048980884,-0.0069065536,-0.012219546,0.007524789,-0.01629924,0.05205392,-0.0017386578,0.1236399,0.037215795,-0.04744638,-0.025152827,0.04468617,-0.0025730277,-0.12771265,0.0070462767,-0.025947409,0.036631763,0.02913809,0.020961381,-0.00019908336,0.008745411,-0.035314903,0.008485811,0.026322134,-0.018337192,0.18162487,0.09644844,-0.055563856,-0.08877326,-0.043991413,0.024030546,-0.005796733,0.072790846,0.057554487,-0.052573655,0.0066050645,-0.096553855,3.9967583e-33,0.018948011,-0.021148274,-0.007058477,0.018272894,0.042200714,0.036418363,-0.114833444,0.045270637,-0.028590709,0.017059159,-0.08884969,-0.0476051,0.06043637,-0.011347919,-0.04444221,-0.051809043,-0.011706849,0.026024366,0.0143739395,-0.015257075,-0.0196649,0.04917927,-0.032431692,0.03937406,0.02506935,0.0184947,0.08054002,-0.008760784,-0.005402762,-0.01485904,0.031259727,-0.064444706,-0.0889169,0.011769405,0.069471434,-0.035995428,-0.016243726,0.019000392,0.041900773,0.09302706,0.023204349,0.08925345,0.0022115328,-0.040127512,0.053561985,-0.06373825,-0.0864313,0.15372904,0.0427145,0.0980516,0.0213971,-0.016603423,0.060760766,0.06600563,-0.008571537,0.060672693,-0.02845591,0.0053243004,0.07986654,0.027109733,0.06891196,0.06534072,-0.028847307,-0.05456748,-0.015077097,0.09600416,-0.073362775,-0.026893605,0.043972712,0.03937892,-0.07961356,-0.041807484,0.035443597,0.013818133,0.047106557,-0.040472034,-0.049003795,0.094886124,-0.011250939,0.031714488,-0.037727337,0.02695518,0.012302453,-0.00782837,-0.050226294,-0.012309439,-0.031020056,0.017555177,-0.023063382,0.07017885,0.04736548,-0.06305124,-0.046542674,-0.014603163,0.0128114885,-3.6327797e-33,0.123131275,-0.13267964,-0.0009496038,-0.0960874,-0.025663026,0.026664028,-0.0045923945,-0.032198675,0.006458967,-0.011567392,0.07887231,0.041687556,0.0828729,0.01970059,0.042631555,-0.06480465,0.026844563,0.025315866,-0.02210141,-0.0014472837,0.056155547,0.047781944,-0.01062929,-0.019626494,0.087756254,0.0023260806,-0.014246881,0.024996871,0.03964039,0.048114914,-0.045461748,-0.052859172,0.006779192,-0.006565555,-0.0611834,0.026979508,0.011808351,-0.00041982922,0.0049906145,0.011911096,-0.056078605,0.021000227,0.012709263,0.08238321,0.027234476,0.026495576,-0.075569004,-0.047133517,-0.034021396,-0.07845587,0.008323866,-0.03380733,-0.06365604,-0.030950526,-0.016877841,-0.0096578235,-0.045599293,-0.029304283,-0.0025865447,-0.041214302,0.03908797,-0.07567618,0.0012033749,-0.07709405,0.03728822,0.029648792,-0.08551735,0.025548158,-0.015669575,-0.044941936,0.070121676,-0.010738552,-0.028538926,0.003167875,-0.03730997,-0.053833157,-0.02000136,-0.057110604,0.043075796,-0.04823041,0.00821388,-0.031896636,-0.0007797611,0.0014712181,-0.08439077,-0.07532547,0.08132248,0.10306112,-0.029217217,0.033732265,-0.07069023,0.03783578,0.009991031,0.14095904,0.10502671,-4.445144e-08,-0.023604838,-0.06546181,0.066850096,0.0634022,0.009139216,0.06325774,0.0107032675,7.830961e-05,0.030043459,-0.07295375,-0.015359595,0.10660543,0.019460782,0.012404284,0.037447307,0.03933819,-0.09245812,0.037643243,-0.008819866,0.005469391,-0.0069403476,-0.017058607,-0.10596089,0.022233715,-0.0026245883,-0.03986426,0.07545893,0.03406499,-0.039759904,-0.08505861,-0.033706542,0.01661404,0.048246287,-0.036937613,-0.04306434,0.018387409,-0.06621063,-0.011693543,-0.018436516,-0.017611543,0.023263924,0.0073775146,-0.019880097,0.028658818,0.011837486,0.044573836,0.031099057,-0.01186137,-0.017196484,-0.007973119,0.0825921,-0.022937438,0.062111482,0.023528345,-0.068623595,0.011120699,-0.06582785,-0.0514757,0.032484557,0.0699654,-0.009607145,0.054986496,0.15634018,0.030610217 +1.14.11.34,"This is one of two simultaneous reactions catalysed by the enzyme, which is responsible for ethylene production in bacteria of the Pseudomonas syringae group.In the other reaction [EC 1.13.12.19, 2-oxoglutarate dioxygenase (ethylene-forming)] the enzyme catalyses the dioxygenation of 2-oxoglutarate forming ethylene and three molecules of carbon dioxide.The enzyme catalyses two cycles of the ethylene-forming reaction for each cycle of the succinate-forming reaction, so that the stoichiometry of the products ethylene and succinate is 2:1.",384,1.0,-0.05009563,-0.008131728,-0.054670088,0.007885208,0.087312765,-0.002845126,-0.06979693,0.055085633,0.0049107233,0.007170864,0.053849693,-0.110644594,0.004425095,-0.06635078,-0.06688439,0.03555477,-0.13896391,-0.0450149,-0.0050171968,-0.009990506,0.12173284,0.010545488,-0.041827876,-0.007619969,0.078800745,0.045891866,0.011729145,-0.018047906,-0.022116546,-0.04309221,0.012194212,-0.047778193,-0.021958381,-0.024082374,0.020536382,0.009486623,0.009183556,-0.029548105,0.06781645,-0.0024064821,-0.0090829395,-0.012155298,-0.051188238,-0.04333893,-0.025676316,-0.005147791,-0.000758986,0.024165245,-0.0060841595,-0.09638507,-0.007550558,-0.034007404,-0.055439115,-0.0076914984,0.061563693,-0.009232479,0.0016820783,-0.038084056,-0.05327687,0.020360049,0.051286098,-0.04743523,-0.08696037,0.03564137,0.03789133,-0.07050769,0.060059853,-0.07029163,-0.033610184,-0.020064853,-0.08644487,-0.009953191,0.024982456,0.014342487,0.06508069,-0.03158979,0.026702346,-0.063630275,0.0033359034,0.00940725,0.04746787,0.020619754,0.0053846864,-0.006499178,0.0015801508,-0.022692993,0.053561937,-0.011357498,0.05158441,0.05251735,-0.0020198417,0.030311799,0.006757288,-0.0057954104,-0.043143936,0.09756203,0.021160575,0.11030595,0.096561655,-0.033964742,-0.021479739,0.049148068,-0.044446405,-0.13343827,-0.02038651,-0.035394184,0.010560859,0.02062709,0.011856389,0.014852448,0.05641824,-0.04670935,-7.520261e-05,0.05433537,-0.015164618,0.16923432,0.11558951,-0.056261726,-0.06544608,-0.067791335,0.024541318,-0.017987972,0.036065813,0.044024423,-0.060809456,-0.009426191,-0.08618092,3.3436525e-33,0.033969376,-0.012107827,-0.03202624,0.01787545,0.05209208,0.038499344,-0.11721475,0.06931038,-0.029064843,-0.008342234,-0.09617346,-0.057605565,0.04261202,-0.04252,-0.052371792,-0.070723034,0.019026855,0.038909458,0.038288135,-0.018453868,-0.02278885,0.0012883695,-0.027439214,0.009106636,0.028130367,0.014380381,0.060220264,-0.008965493,-0.01459358,-0.028939448,0.087053604,-0.050032414,-0.08320205,0.021504069,0.04356994,-0.05932396,-0.021066274,0.029805856,0.06238167,0.07436702,0.016275767,0.11228402,0.05244223,-0.045812134,0.05091615,-0.030345056,-0.054168865,0.13009918,0.04344461,0.11397235,-0.015827935,0.040621582,0.111763984,-0.010198096,0.015810844,0.05259094,-0.0089800265,-0.033301637,0.041093726,0.059817716,0.0030175508,0.07479136,-0.053028967,-0.016653813,-0.040616088,0.07094661,-0.036956802,0.0070383083,0.034601036,0.06281873,-0.091621205,-0.028004648,0.032839224,-0.020736266,0.05380032,-0.050438445,-0.04765675,0.049856644,-0.0039844736,0.037016764,-0.06126199,0.065314606,-0.021074802,-0.050525893,-0.06468807,-0.038447592,-0.0849835,0.03130951,0.002037858,0.10014597,0.08000278,-0.039402686,-0.045805257,-0.021228751,0.04292878,-4.5137448e-33,0.0896403,-0.08779044,0.0006039385,-0.0915415,0.013231861,0.027414938,-0.0081681805,-0.0069203316,0.014190111,0.013712827,0.09742949,0.04083093,0.057823148,0.0013364546,0.023769507,-0.059344605,0.012292477,0.04652516,-0.04120549,-0.0066178236,0.052045092,0.06967806,-0.0065852506,-0.029050812,0.06954038,-0.0033863396,0.016185911,0.040458955,0.04360125,0.014310458,-0.024972916,-0.071523525,-0.0069415527,0.021934936,-0.039676342,0.024464538,-0.0033013253,-0.022463646,0.015395411,0.051424176,-0.02589615,0.04769428,-0.018368475,0.06911961,0.0017993136,0.0139997015,-0.066336595,-0.022678558,0.0068488973,-0.06875436,0.031296756,-0.018218959,-0.047402002,-0.012216718,0.0069956263,0.033593632,-0.038636424,0.0051389965,-0.018214723,-0.036215756,0.03198266,-0.06141452,-0.01232772,-0.041302722,0.009872916,0.015026463,-0.095623456,0.020145899,-0.013711595,-0.0045227814,0.07069126,-0.006763058,-0.058333836,-0.048940346,-0.09323873,-0.04832007,-0.03262924,-0.107952595,-0.029823918,-0.029210813,0.019910825,-0.005872055,0.007962222,0.012697193,-0.097531594,-0.07042734,0.08632868,0.0700793,-0.0793213,0.025982067,-0.050728124,0.059771962,-0.018607484,0.149757,0.09152377,-3.957549e-08,-0.03391951,-0.07309883,0.099527724,0.02964118,0.0033803387,0.044600524,0.01469454,0.024197767,0.019579662,-0.03113038,-0.023288267,0.12200251,0.054189794,-0.015665544,0.058864564,-0.0065452475,-0.06746728,-0.0044740313,-0.03758327,-0.040971044,-0.01131086,-0.037174918,-0.12770696,0.047513787,-0.012155187,-0.021541366,0.03919503,0.042038772,-0.015087083,-0.08000984,-0.014241614,0.015799096,0.020328123,-0.050773643,-0.080655575,-0.03199836,-0.062193986,-0.030095473,-0.0031294741,-0.05535116,0.056745365,-0.015476632,-0.058009528,0.05834287,-0.003258436,0.04542449,0.009640859,-0.006545699,-0.015057987,-0.0016296848,0.06219641,-0.009277052,0.052946027,0.004814133,-0.06398992,0.008749604,-0.07582251,-0.03674742,0.012827213,0.078132376,0.02140955,0.043557912,0.17985688,0.026166087 +1.14.13.131,"The enzyme participates exclusively in sulfur dissimilation. It has lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides. Its activity is stimulated by combined addition of FMN, and, after depletion of cations, of Mg2+ and Fe2+. The enzymes from bacteria of the Hyphomicrobium genus are a two component system that includes an FMN-dependent reductase subunit and a monooxygenase subunit.",384,1.0,0.0009836645,-0.02628269,-0.10373291,0.048599597,0.026449071,0.02735753,-0.083308645,0.022002555,0.015743092,-0.09472404,0.023598745,-0.0062407875,0.00945349,0.018600652,-0.030966416,0.02348455,-0.06005363,0.057127956,-0.006434521,-0.059401885,0.06732752,-0.017597012,-0.052308284,-0.020782905,-0.057356365,0.003003462,0.0002817456,0.022096837,-0.06093112,-0.063445866,0.032385375,-0.005550366,0.05569561,-0.036303744,0.032242425,0.113628544,-0.0008375575,-0.037418745,0.0035645885,-0.027695345,-0.023902543,0.014133862,-0.029679427,-0.027854532,-0.06768268,-0.055601247,0.04321305,-0.023986937,0.015625397,-0.024482341,-0.055395126,0.00023122515,-0.0051789223,0.1102235,0.02440881,0.0450499,-0.042057417,0.004188265,-0.0235749,-0.06295735,-0.023894977,0.059682086,-0.022338945,-0.046584602,0.09154733,-0.013697505,0.008552188,-0.09117364,0.010518788,-0.019863011,-0.016282689,-0.047735166,-0.019058345,-0.039873105,-0.04716771,0.014617773,-0.011464757,-0.031567723,0.05637646,-0.0028211894,0.049506783,0.012705415,0.053665243,0.078100055,0.0053009256,-0.07043654,0.008956076,-0.034326505,0.013186228,0.023283638,0.040287513,5.7804515e-05,-0.0028994945,-0.06528785,-0.05820123,0.0030323833,-0.030392382,0.11775371,0.0017735882,0.006526327,0.028626226,-0.017257823,-0.07077732,-0.042799026,-0.042703923,0.0046494994,0.024121888,0.13662012,0.05138369,0.019599793,0.023289403,0.02430766,-0.0065240734,-0.0036104128,-0.039770156,0.12870818,0.06652284,-0.052791603,-0.09117041,-0.013459028,0.011910258,0.021837492,0.07114455,0.045045905,0.03393916,-0.034691613,-0.20097665,1.9303873e-33,0.07764905,0.030394172,0.046947904,-0.053810023,-0.038793214,-0.047617987,-0.052697316,0.036690973,0.026966423,0.014568338,-0.08092116,-0.014121115,0.0074350755,-0.018447332,-0.07627121,-0.071882404,-0.03183296,0.005404253,0.07156017,0.051197063,0.0064767255,0.044108704,0.017840717,-0.022796154,0.03827357,0.039007284,0.008901865,-0.012631401,0.0007001382,0.024920935,0.059642438,-0.17090224,-0.061998054,0.015909184,0.12981194,-0.017880896,-0.050859243,0.028133161,-0.030582799,0.00074349303,-0.03255482,0.015145603,0.001911239,-0.05163853,0.07554494,-0.05910127,-0.025087122,0.06383453,0.032943718,0.08190313,0.057644643,-0.06611714,0.06322502,-0.025352577,-0.072882555,-0.0045964886,-0.0033533499,0.003441024,0.029801253,0.08157621,-0.014498362,0.01444545,-0.053286057,0.010703117,0.043336928,0.00961928,-0.01214952,-0.04508466,0.019263364,0.07736216,-0.08148085,-0.028503444,0.084793776,0.05387876,-0.007744387,-0.0080159735,-0.041568607,-0.036398258,0.0695871,0.014649358,-0.013412291,-0.08414083,0.0131895095,-0.054656554,-0.06701743,-0.0071279006,-0.07055228,-0.042045265,-0.057146426,-0.0032246625,0.08338547,-0.028580766,-0.027781015,0.0022594242,0.05164184,-3.44985e-33,0.032246705,-0.07051588,0.011561429,-0.1313446,-0.062849425,0.13231243,0.0249525,0.020950157,-0.027896075,0.0364527,0.0871034,0.0049856654,-0.024114965,-0.041879874,0.009065912,0.04819583,0.024818392,0.07884996,0.004513062,0.0030576945,-0.073158175,0.15071996,0.0007378891,-0.0062329355,0.035981663,0.031656545,0.039889358,0.10304916,0.11369187,0.05666783,-0.004020053,0.045077745,-0.061626658,-0.06575888,0.0048865722,0.050848134,-0.10791355,0.006610055,0.007069482,0.008904899,0.0017666616,-0.026142174,0.05456621,0.09173121,0.011813622,0.062024806,-0.10763272,0.018962014,0.04604877,-0.033802137,0.023153605,-0.03779103,-0.028838912,0.042250987,0.025041722,0.032849915,-0.010108841,0.034811333,-0.04137973,0.027207145,-0.025199182,-0.05994344,0.039971687,-0.014323134,-0.019089513,0.05248562,-0.017633675,-0.025386488,0.062246975,0.0347882,0.050701525,0.01868171,0.03190014,0.0018760826,-0.069145486,0.042320233,-0.07152922,0.017159872,0.0029988866,0.027300956,-0.009096088,0.052291896,-0.026210647,-0.11445047,0.047290713,-0.109554276,-0.007403942,0.09520452,0.022787768,0.0037186507,0.013944745,0.014881403,-0.04471231,-0.021958832,-0.024649682,-4.059146e-08,-0.040518086,-0.108563885,0.062204085,-0.013998962,0.020987172,0.049906097,0.021033207,-0.0047528837,0.0013069096,0.05767997,0.021269754,0.06240414,-0.014540827,-0.056611273,0.04968025,0.004031152,0.005841152,0.027445791,-0.035355125,-0.061846264,-0.031693578,-0.043655816,-0.11566094,0.06725152,0.053978413,-0.07919376,0.07204915,-0.000588614,-0.0016378823,-0.028275363,0.070600756,0.055111863,-0.06672751,-0.022900088,-0.103465974,0.0033602032,-0.020659758,-0.013851356,-0.06690519,-0.049292337,-0.02297425,0.036616877,-0.08305651,0.03281781,0.018020313,0.049492255,0.0012841591,0.045376524,-0.040441327,0.038739912,0.03275229,-0.016797278,-0.046460073,-0.04200539,-0.10297008,0.061022114,0.06479151,-0.08574103,-0.018933073,-0.009493068,0.03954001,0.015444358,0.116155274,-0.03162115 +1.14.13.132,"A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor, NADPH, is coupled via EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].",384,1.0,-0.083651386,-0.064458735,-0.09682059,0.01867797,0.09556005,0.013538877,-0.071363546,0.071996376,0.052327473,-0.044352368,-0.0008768467,0.020482974,-0.07526684,0.0059737614,-0.09723806,0.028005263,-0.082666725,-0.011934572,-0.019910896,-0.018926568,0.0010347049,0.007781573,0.057403903,-0.03379154,0.054246962,-0.011901505,0.03639201,-0.051638573,-0.050623246,-0.0430015,0.08157292,0.024005009,0.037235126,-0.0060636397,-0.070085615,0.058808297,0.039968915,-0.021427114,-0.021118112,0.034945033,0.027804201,-0.04289839,0.017253945,-0.030989448,0.05807862,-0.0072002844,-0.0256503,0.051271405,0.005424335,0.031002352,-0.026919227,-0.052852873,-0.08767472,0.029852062,-0.002813666,0.042197634,0.01831883,-0.06616479,0.016965356,-0.0004255115,0.03103769,0.0024912695,0.033856086,-0.0086841015,0.034238532,-0.045763228,-0.01722962,-0.06583049,0.02025075,-0.04977898,-0.03878061,-0.0391467,-0.04730768,0.044850565,0.015536902,0.06035057,-0.09706782,-0.052451655,0.056420695,0.006204151,0.059969094,-0.030061234,0.018970642,0.05668136,0.11361072,-0.006614709,0.021952424,0.0066722482,-0.05800138,0.017514227,-0.02177191,-0.004322186,-0.018271502,0.02751203,-0.11284095,0.07431294,0.0506015,0.022654919,-0.06356216,-0.031707216,-0.014308831,0.0234101,0.012420214,-0.060373817,-0.0776589,-0.07722351,0.006921036,0.08250527,-0.021615028,-0.0687406,-0.032938875,-0.042267352,0.0055564977,-0.042765133,0.0017522193,0.077203736,-0.06159665,-0.06547521,-0.029086614,0.02901339,-0.026616197,0.09731715,0.024634572,0.13428064,0.07617514,-0.0013206027,-0.13199706,2.0005178e-33,0.09382641,0.062425494,-0.010472928,-0.0031607258,-0.012324918,0.010669908,-0.09009179,0.007204152,0.0028736342,-0.06514736,-0.004404489,-0.008726095,0.04145178,-0.0703636,0.046823867,-0.030351346,-0.013189488,-0.016692113,0.096070945,-0.11980806,0.020674944,0.04983584,-0.039570607,0.067540765,0.030896436,-0.0018400847,-0.06537305,0.043960944,0.064230934,0.04030312,-0.019019242,-0.038450755,-0.05309262,-0.007162686,-0.033677503,0.018017255,-0.08740829,-0.10808568,-0.08326916,0.07044128,-0.007552403,-0.02696179,-0.021207782,0.0019890454,0.04467494,-0.053832058,-0.08158461,0.083527535,0.02399205,0.06683747,-0.033487696,-0.05199975,0.13587406,0.052914567,-0.04438425,0.010850308,-0.07565676,-0.0007576436,0.013862844,0.027706427,0.04528582,0.1000111,-0.03938532,0.08652672,-0.106368884,0.015167038,0.01768958,-0.10128806,-0.017120024,0.09756258,0.025174564,0.0014563979,0.06968357,0.011907845,0.08143658,-0.04078284,-0.025431717,-0.039482523,-0.005919649,-0.016691033,-0.028912665,-0.027792007,-0.049768258,-0.036588453,-0.025310323,0.004880874,-0.0417281,-0.021033794,0.007639299,0.032834705,0.05690793,-0.08532606,-0.017664202,-0.005841349,0.03523033,-8.359185e-34,0.038340364,-0.08480922,0.054682717,0.0019584736,0.03503195,0.045305025,0.047954045,-0.048764933,0.024175048,-0.057402696,0.056999836,-0.07294631,0.013794123,-0.03636051,0.053599466,0.011259426,-0.010099962,-0.049179964,0.08673576,0.041902356,-0.012966226,-0.002385301,0.06168667,0.06846261,0.0576582,0.0052528395,0.010544399,-0.014940257,0.03791459,0.034727477,-0.057637416,0.05329933,-0.053685915,-0.009967573,-0.076409675,0.060570333,-0.012317209,0.0052707074,-0.0144798905,0.03564666,-0.02955254,0.01927348,-0.005460423,0.06710183,0.08697476,0.04314902,-0.01748144,0.06286188,0.09200151,-0.07973498,0.02142497,0.06549766,0.012277038,0.03264322,0.053054288,0.043462463,0.03613183,0.0857376,0.006712886,-0.02399218,-0.010268897,-0.09580098,0.020691184,-0.0035481006,0.07958852,0.056620218,0.037343778,0.12304735,-0.02477739,0.033227365,0.12753159,0.00528846,0.02334491,0.082126215,0.012533457,-0.070533425,-0.0034602336,0.06285152,-0.0016498227,-0.01537105,0.033878103,0.015326714,0.009445784,-0.019499071,-0.05905319,-0.09315584,0.036258873,0.0911414,-0.006015943,0.03748708,-0.04426995,0.037574206,-0.056840695,-0.007004661,0.07084418,-3.4871917e-08,0.028136719,-0.03918679,0.01634888,-0.0355003,0.13417102,-0.0007854466,0.0015315854,-0.019214086,0.009930889,-0.01751634,-0.06432297,0.13171577,0.050692696,-0.026405765,0.06262283,-0.036804695,-0.00852493,0.038958833,-0.00479439,0.014870959,-0.0063959947,0.03654806,-0.12391629,0.010575387,-0.055811968,-0.02143921,0.00653158,-0.017012503,0.0240945,-0.050844185,0.007399009,0.025501708,0.038138073,-0.017558305,-0.106512606,0.018498838,-0.0133502865,-0.01819168,-0.054586712,0.061740912,-0.06592259,-0.02540088,-0.014854817,-0.025081042,0.0068062763,-0.0042540487,0.06231106,-0.07936323,-0.0016596257,-0.025351282,-0.005146505,-0.02952977,0.024540624,-0.03159407,-0.048040606,0.0089324275,-0.024534633,-0.098820396,-0.015218641,-0.07173848,0.0033741842,0.019445818,0.12929274,0.043295287 +1.14.14.9,"The enzyme from Escherichia coli attacks a broad spectrum of phenolic compounds. The enzyme uses FADH2 as a substrate rather than a cofactor [4]. FADH2 is provided by EC 1.5.1.36, flavin reductase (NADH) [5,6]. ",384,0.99999994,-0.02470058,-0.07152656,-0.084381565,-0.007361768,0.13740572,0.07432856,-0.07932961,0.08425678,0.04579239,-0.07039749,0.010086583,-0.048605647,-0.15692689,0.038907472,0.007109145,0.013365475,-0.030933,0.027705302,0.030305985,-0.061909202,0.016688794,-0.003312939,0.0021724333,-0.011100485,-0.03941311,0.022845715,0.03419706,0.007366565,-0.03207027,-0.048956566,0.033001762,-0.03162848,0.019334663,-0.019949172,-0.013675444,0.0475564,0.007845571,-0.1010231,0.082331754,-0.010292884,0.0036970843,-0.005929665,0.06390747,-0.052843187,0.033423755,-0.045787945,-0.008468982,0.08034532,0.02187329,0.0062929858,-0.059547145,0.004351917,-0.0076094596,0.000290873,0.043118235,0.014370628,-0.02041764,-0.046953656,-0.012342808,0.0351491,0.02710442,-0.03019999,-0.030144034,-0.0011210255,-0.035309214,-0.035558715,0.004569222,-0.081853025,0.072943605,-0.009324976,-0.061201386,-0.023969091,0.020119933,-0.02385524,0.036202963,0.05682445,-0.062464513,-0.012529742,0.067586206,-0.008800557,0.06536323,-0.028821846,0.045423012,0.085548446,0.07825081,0.008369203,-0.010790632,0.00030904825,-0.0040653683,0.083714336,0.074402675,-0.009703961,0.05922633,-0.007241309,-0.084651515,0.0689224,0.03409383,-0.0014766713,-0.016688867,-0.011733314,-0.022043724,0.027742377,-0.01771315,-0.035319395,-0.08685225,-0.027572911,0.008855061,0.09319023,-0.0010611237,0.0047210795,0.037650585,0.016219378,0.02872627,-0.095175825,-0.02983575,0.04045885,0.00033008785,-0.094668984,-0.08799263,0.009181526,-0.0016971912,-0.037944566,0.036724325,0.061470903,-0.021181613,-0.06566602,-0.12262305,2.6446132e-33,0.07574157,0.065214105,0.006861261,-0.052707825,0.029163988,-0.035464667,-0.10553564,0.022357387,0.0016465622,-0.064953506,0.031389114,-0.025920492,0.056236964,-0.03484364,0.047086887,0.01310066,-0.020623757,-0.049162623,0.06908657,-0.02372169,0.0491725,-0.0043249866,0.0279646,0.054994393,-0.0025782299,-0.011861974,-0.065500714,0.08400085,-0.032757185,0.071080066,-0.005009201,-0.10537308,-0.047400855,0.053924013,-0.009613583,-0.020548904,-0.11754805,-0.060501106,-0.057184324,0.05289728,0.0016786591,0.051559962,-0.0023171157,0.009660597,0.078715734,-0.080551125,-0.0343153,0.094721794,0.039405536,0.12000191,-0.0113337105,-0.041183308,0.072913006,0.03714502,-0.03963502,0.059713494,0.0005208353,0.00058016856,0.038178682,0.028771017,0.0038001642,0.08356453,-0.035531234,0.030825345,-0.08185534,0.03884282,0.0068290606,-0.06841329,0.0045388103,0.13587351,-0.017437622,0.01583196,0.048526023,0.0013329927,0.03409032,-0.04545112,-0.020569738,0.034465037,0.037860066,0.025539268,-0.012850003,-0.002326557,0.03196322,0.029388806,-0.093916334,0.04415973,-0.028373098,0.014516408,0.008993169,0.010280204,0.050357386,-0.14206706,0.019773232,-0.02139105,0.013482537,-2.5072345e-33,0.046660203,-0.06383817,0.035576418,-0.10747844,-0.05217251,0.009954886,-0.0009896429,-0.045345385,0.082233265,0.0061739506,0.033425156,0.0056115612,0.005893351,-0.020271126,0.092107855,-0.012693585,-0.024516786,0.02917166,0.023023285,-0.007536377,0.014152323,0.011362978,0.042579457,0.018259095,0.04207837,0.0072427625,-0.048003826,0.013833007,0.08089911,0.016341494,-0.063926674,0.044019297,-0.004817565,-0.015237487,-0.017695636,0.01676383,-0.048702672,0.03452416,-0.020839619,-0.006502822,0.063995354,0.05882816,-0.05649568,0.025165174,0.01388831,0.09162903,-0.08317658,0.023928355,0.044957623,-0.12255039,-0.01981836,0.031397913,-0.056773905,-0.0123635065,0.01028752,0.054728188,0.034414213,-0.0014057651,0.005716102,0.015135893,-0.039161917,-0.080866,-0.011679336,0.028501067,0.06795438,-0.0071949735,-0.009026522,0.08989949,-0.0045326957,0.009378691,0.061366662,0.04437381,0.022094293,0.10583752,-0.044118878,-0.069806635,-0.117083326,-0.0113167865,-0.020080835,0.07140687,0.07517099,-0.023642786,-0.02073841,-0.02643852,0.027037837,-0.04224638,0.017368859,0.06904711,-0.008510138,-0.007882668,0.012817176,0.00913733,-0.014411636,0.042762354,0.041372664,-3.910377e-08,0.009622956,-0.094143055,0.09148306,-0.066713825,0.024068194,0.07814454,-0.00058747863,-0.014002673,0.0005070489,-0.012453356,-0.037804563,0.09867073,0.0010765966,0.013438247,-0.030815499,0.008655763,-0.07943113,-0.04399397,-0.047613177,-0.022676315,-0.06487391,-0.0042209295,-0.06723965,-0.0042857784,-0.0031983354,-0.018185467,0.0049936213,-0.03933352,-0.060491715,-0.025129268,-0.02894773,-0.028204542,0.051220786,0.065326184,-0.14378957,0.02398355,0.0128584625,-0.05011635,-0.09792875,0.08460034,-0.010675178,-0.038131367,-0.07430626,0.023465946,0.025067773,0.033495095,0.036347695,0.00474226,-0.012872667,-0.032240182,0.050480388,-0.03993208,-0.023609392,-0.019609602,-0.118356824,-0.033205483,-0.017049422,-0.10497372,-0.0027720255,-0.07093554,0.12025598,0.048939202,0.2041029,0.020183545 +1.20.9.1,"Contains a molybdopterin centre comprising two molybdopterin guanosine dinucleotide cofactors bound to molybdenum, a [3Fe-4S] cluster and a Rieske-type [2Fe-2S] cluster. Isolated from beta-proteobacteria. Also uses a c-type cytochrome or O2 as acceptors.",384,1.0,-0.044648036,-0.10315452,-0.15990986,0.025781708,0.09042006,0.0052585797,-0.044516705,0.033811584,0.003597033,-0.09032127,0.08004018,-0.07058653,-0.07033681,0.05474953,-0.064110614,0.019541817,-0.017300837,0.0015053184,0.08726527,0.04859223,-0.020856617,0.026213448,0.073633365,-0.028529465,-0.045404736,0.04723907,0.038172454,-0.04960155,0.053753473,-0.061858617,0.005702018,-0.012943502,0.04370699,-0.005866903,0.08015297,0.07427625,0.018887946,-0.010284888,0.06778201,0.06936246,0.016154421,0.06542585,0.052943613,-0.003117767,0.03166772,-0.013499564,-0.059419643,0.033118594,0.0048862454,-0.0491984,0.02695758,-0.08065689,-0.07399845,0.10592311,-0.013518747,-0.010403124,-0.062929645,-0.011497454,0.08227625,0.092613764,0.08080416,0.016377453,0.10976106,0.006429014,0.046396602,-0.00588193,0.0044964203,-0.03455418,0.035526272,-0.099907935,-0.05126025,0.03532834,0.00085138035,0.045120742,-0.027135788,0.076769456,0.021430496,0.011802597,0.036430612,-0.032663926,-0.016341178,0.010808183,0.09381219,0.072537236,0.05350349,-0.03629536,-0.035520464,0.05044294,-0.046443466,-0.01696868,0.029818555,0.031106716,0.02191141,-0.06587911,-0.07213621,-0.033242572,0.007746788,-0.0038798854,-0.008827134,0.04920647,-0.079467244,0.05487827,0.03626395,-0.07682862,-0.06541395,0.020003187,-0.014148539,0.012118711,0.056197327,0.054614894,-0.025314841,0.11188188,-0.0112705715,-0.04301995,0.0045262594,-0.05831885,0.024079433,0.018310612,0.06733697,0.04166408,0.013013918,-0.033269703,-0.019381182,-0.0221739,-0.0573342,0.08156542,-0.073017865,5.7454296e-33,0.049811605,0.013313892,0.052993424,-0.01868713,0.029959507,0.007320665,-0.046869576,-0.05190949,-0.04485429,-0.017854076,-0.02171654,-0.05820921,0.013213019,0.027875181,0.062201746,-0.006944652,-0.06758673,-0.044200733,0.07137753,-0.09103691,-0.022780795,0.083469175,-0.01720546,0.0011946349,0.0834952,0.0076481286,-0.052900575,-0.027840879,0.062255207,0.008102543,-0.0018918026,-0.07316668,-0.11799381,-0.005753961,0.005717593,-0.035924792,-0.0153272115,-0.1249567,0.0003018545,-0.031222688,-0.0703891,0.015890233,0.005940583,-0.09052265,0.101291,-0.024083301,-0.029228233,0.03523785,0.044465233,0.0024753802,-0.012096262,-0.09047749,-0.043316334,-0.020280177,-0.074292086,-0.054620244,-0.01795624,0.009361416,0.060709197,0.06283791,0.023120683,0.03344368,0.017757395,-0.020116555,0.022133213,-0.019119918,-0.11626141,-0.06479918,0.0049478007,0.0066521405,-0.0066594905,0.010743907,0.062893614,-0.058220655,-0.09415862,-0.06902822,0.0026051502,-0.09292747,-0.0013597342,0.0050932304,-0.0319513,-0.010152472,0.02538867,-0.04423258,-0.013933192,0.03901997,-0.044929784,-0.06993987,-0.018530294,0.028315159,-0.0018531235,0.070988,-0.07936872,-0.0004501933,-0.027812142,-5.17817e-33,0.102452874,-0.0742675,0.06341032,-0.11841599,-0.07014866,0.04492981,-0.023298336,-0.017346438,0.032740302,-0.03463734,0.035418905,-0.0065877405,0.06880219,-0.12745959,0.020486327,0.0008420518,-0.009186283,0.120625086,0.038552478,-0.0021069394,0.06929855,-0.005116536,0.04068195,0.016099252,0.04659773,0.054550078,-0.025711272,0.05712749,0.04061233,0.047332384,-0.039436657,0.005063124,-0.066188924,-0.0669485,-0.056169778,-0.057831455,-0.056830447,-0.0014977596,0.035125393,-0.055424754,-0.024586067,0.052112427,-0.049736217,0.10297511,0.053092476,0.09567861,0.038560215,0.009621829,0.06620085,-0.004096152,-0.046946056,-0.11238683,-0.06276551,0.021038434,-0.025426503,0.04749759,-0.023588512,-0.022591246,-0.030029053,-0.028813725,0.029737562,-0.06855524,-0.035637464,0.009754672,0.09767011,0.05437966,0.009734849,0.096499406,0.06986552,-0.018629517,0.029724184,0.037388578,0.02691695,0.015413026,0.019060317,-0.0007904449,-0.049963307,-0.017762557,0.009540624,-0.01358535,0.0066265925,0.023015462,-0.039397277,-0.011332982,0.08923674,-0.00012637147,0.032192077,0.08476858,0.041795306,0.009668544,-0.057528667,0.054808006,0.0025304998,0.0028639173,0.039634604,-3.765192e-08,0.07203539,-0.10662015,0.03664759,-0.057007063,0.026576394,0.03374926,-0.032110143,0.011984494,-0.03911552,0.014940223,0.03117292,0.03537198,-0.021979835,-0.07144883,0.07490954,0.087495334,-0.0408191,0.015521025,-0.020022942,0.011704936,-0.013593707,-0.03222897,-0.024918456,0.12867436,-0.05506164,-0.044979796,0.019516263,0.032722317,-0.045134712,0.055515263,0.010884962,-0.021504233,0.025902046,-0.028636917,-0.026076792,0.04629653,-0.015157322,-0.018100094,-0.02931269,-0.025803883,-0.011406197,-0.022020398,-0.056878783,0.016462032,-0.028903306,-0.0070455484,-0.01081842,0.07961922,-0.02259133,-0.010509851,0.021594262,-0.06970001,-0.020977661,0.031005057,-0.12796314,0.0017153202,-0.046225633,-0.054438405,0.017097468,-0.066785,0.025504673,-0.04891853,0.12949616,0.025215143 +2.1.1.231,"The enzyme catalyses the 4'-methylation of naringenin. In vitro it catalyses the 4'-methylation of apigenin, quercetin, daidzein and genistein. ",384,0.99999994,0.010026462,0.05508865,-0.049602002,0.0035563982,-0.01566288,0.060533084,-0.053974364,0.0051336195,0.018868962,-0.045084637,-0.03852567,-0.02917855,-0.024880882,0.0074007614,-0.039889846,0.03695921,-0.14133237,0.08183885,-0.13013846,-0.07182531,0.06272966,-0.017282898,0.056631755,-0.03941044,0.046273626,-0.064028434,0.05642875,-0.062180404,0.060810246,-0.05098839,0.060742807,0.0704485,-0.06614543,0.0035537465,-0.02391537,0.05256767,-0.026180333,-0.038539752,0.018243657,-0.034059227,0.08717275,0.007537342,-0.06810272,-0.042684987,-0.0010046592,-0.05801896,-0.062617965,-0.03559177,0.043165535,0.032177214,-0.055250358,-0.04545302,0.018656842,0.0010430819,0.037148666,-0.018720055,-0.024763888,-0.032509107,0.011712082,0.06274264,0.14640045,-0.027911648,-0.038385738,-0.006715926,-0.04522829,0.03320501,0.044290468,-0.021648213,-0.00014182043,-0.09100844,0.0076306355,-0.04890118,-0.066488124,-0.0010858928,0.044249117,0.044990327,0.04118963,-0.05057934,-0.03888157,-0.012768791,0.024353893,0.07218962,0.06069928,0.028368007,0.08328496,0.060425725,0.019249594,0.024859896,0.04926492,0.072415575,0.013527196,0.036331862,0.0026806125,-0.04792558,-0.008023014,0.039031975,-0.02329765,-0.050642557,0.021836365,0.051329862,0.08106232,0.03562896,-0.059818454,-0.02511591,-0.023543201,0.057861254,0.026597498,0.021900427,-0.021966645,0.020390205,0.022133226,-0.023295062,0.079339094,-0.008820784,-0.04957309,0.12880579,-0.041661516,-0.025243327,-0.042030975,-0.03317416,0.0024227926,0.0095089115,0.006976222,0.014942992,0.0015941539,0.018290378,-0.052837785,1.693377e-33,0.049289733,0.08421028,-0.023585774,-0.018491624,0.020492988,-0.01243304,-0.05447648,0.07674644,0.0046498165,-0.09637824,-0.10808203,-0.07340978,-0.027587354,0.018215101,-0.007341466,-0.05049034,0.002761657,-0.03770523,-0.0053228736,0.0045939586,-0.027901521,0.023463422,-0.061934467,0.017082844,-0.085671075,0.03407005,0.008760469,0.019141257,0.010379437,-0.049775485,0.022907807,-0.087029554,-0.027831843,0.023222035,-0.0075276857,0.07339435,-0.004040983,0.036941078,0.02734109,0.13275136,-0.02297433,0.035486903,0.037442766,-0.01409505,-0.014836683,-0.00010559075,-0.09237166,0.023038052,0.019597085,0.014304531,0.020295626,0.04915276,0.070298724,0.029550172,-0.005490064,0.01590847,-0.005840994,-0.08979918,0.028151138,0.0054280106,0.011256976,-0.08110264,0.020992197,0.064792916,-0.023066176,0.018506408,-0.0037373055,-0.027180392,0.0126549015,0.009546378,-0.036966007,0.021559369,0.056613326,-0.005562475,0.06967727,-0.0055306987,-0.04209234,-0.0018551039,0.014571812,0.016728686,-0.01283698,0.07541724,-0.047894653,0.039225962,-0.06004744,-0.057289682,0.0021575748,-0.019331539,0.0399799,0.0054729558,0.035020113,-0.066151135,-0.1018718,-0.03458932,-0.0151895145,-1.9179412e-33,0.08403459,-0.018035175,-0.0026514505,-0.059992198,-0.044304006,0.034545936,0.042431004,-0.03250853,-0.1051962,-0.030320516,0.11413177,-0.013625561,0.093858875,-0.01811373,0.009698309,0.013165106,0.0656463,0.051237684,-0.00079117995,0.008296491,-0.036279943,0.08575692,-0.09045111,0.031717174,0.07184583,0.005469761,0.028719366,-0.01590824,0.06475833,0.089566074,-0.009118745,-0.027876318,-0.029899944,-0.013125099,0.003317011,0.1306292,0.10116969,0.0024425366,-0.08857181,-0.03655599,-0.01736167,0.026067112,-0.025882239,0.091051154,0.03955939,0.030651651,-0.12499356,0.0245556,-0.034091443,-0.014572651,0.099958144,0.068500616,0.041752197,-0.06374038,0.01663862,0.02755521,0.07142249,-0.07008597,-0.015113903,-0.025768213,-0.08435237,-0.04931517,0.05983811,-0.047979113,-0.062619306,0.051185273,-0.045895677,0.045952212,0.009933127,-0.062199168,0.024746416,0.027456032,0.046920657,0.05486409,-0.08677985,-0.049685422,-0.007150604,-0.026570931,0.00017780809,-0.07740954,-0.053114075,-0.02163565,0.034573436,-0.1041671,-0.084854744,-0.04465727,0.08343628,0.080554694,0.0076944544,-0.017277088,-0.026974214,-0.0045996523,-0.1487853,0.05221009,0.039729696,-3.1902147e-08,0.03329008,-0.08841562,0.023413036,-0.024765303,-0.029077146,0.054515127,-0.011924732,0.013180443,-0.004216266,-0.041969985,0.0034238806,0.12762055,-0.08031459,0.019236496,-0.002574885,0.038592637,-0.034795184,0.029552804,-0.025938388,-0.0697173,-0.050200626,0.10098456,-0.15338774,-0.055924468,0.014255632,-0.033173535,-0.03985338,0.095606595,0.08688124,-0.026769336,0.042163428,0.045418296,0.07266862,-0.07843344,-0.03746214,-0.008816521,-0.0018235631,-0.024661027,0.055562966,-0.08430367,0.002199664,0.004774766,-0.008355727,-0.009416361,-0.06856015,-0.05015874,0.03441751,0.034047328,0.060706273,0.045159765,0.025337884,-0.0036128426,0.03271603,-0.02589349,-0.0723888,-0.0024687347,-0.0053668935,-0.035526756,-0.030594083,-0.036254186,0.00018975545,0.010774024,0.14789812,-0.0038606226 +2.1.1.232,"The enzyme is involved in the biosynthesis of the sakuranetin, an inducible defense mechanism of the plant Oryza sativa (Asian rice) against pathogen attack. ",384,1.0,-0.0858331,-0.03249772,-0.056891873,0.028224766,0.09895639,0.114244856,-0.03687999,-0.014614236,0.026729755,0.02117439,0.13748072,0.025012923,-0.046087526,0.0056101624,-0.059076343,0.040176366,-0.050671555,0.021907419,-0.089976214,-0.0782585,0.029146489,0.040725157,-0.015991133,0.018965801,0.011792538,-0.049748763,0.01242529,0.012993651,0.02375104,-0.058132492,-0.059010454,-0.005541178,0.022896193,0.023777591,-0.020797607,0.012390635,0.034540884,-0.11230537,0.028480716,-0.07449517,0.05551838,-0.02085016,0.009136533,-0.065420106,-0.029502152,-0.039043333,-0.011876966,-0.07590983,0.08285313,-0.081054755,-0.054822247,-0.012915941,0.032836165,0.014288961,0.034628376,-0.01844307,0.006641586,0.012988743,-0.050469525,0.03982365,-0.009577011,-0.01986502,0.01543713,0.042985376,-0.044000298,-0.030131174,-0.05077534,0.019573746,0.008476253,-0.025151266,0.057194676,-0.045512643,0.029542435,0.049925655,0.012287599,0.0416264,0.033517376,0.011744166,-0.016223518,-0.014487658,0.04751597,0.00081340736,0.10911338,0.13878594,-0.023564363,0.035599943,0.0012760824,0.035538226,0.057590116,0.042394657,0.06614118,0.019111006,0.039623342,0.019197691,-0.021866368,0.09036939,-0.016180813,-0.12923577,-0.022470647,0.012723729,-0.018116765,0.04035888,-0.033422377,-0.10906764,-0.0154356435,0.017391311,-0.012054449,-0.09002634,0.03855235,0.005910687,0.052384514,-0.08051325,-0.0034292692,0.05547978,-0.09583448,-0.01541833,0.024463953,0.020117577,-0.01701409,-0.026630944,0.03470572,-0.004566673,-0.025975173,0.12927124,-0.07667867,0.005670308,-0.12789682,4.69619e-34,0.05455018,0.008148612,-0.04285749,-0.06453148,0.030870927,-0.124234915,-0.00648712,0.0077938237,-0.00034941905,-0.030286895,-0.108394824,-0.13017505,-0.020781543,0.00894017,0.034401342,-0.020876803,-0.023897968,-0.020958297,0.023852374,0.059188265,0.032769762,-0.0012033372,-0.08070093,-0.006865269,0.014188923,0.02035243,0.01895469,-0.003974431,0.0046920506,-0.025793161,0.050558038,-0.05029635,-0.055942245,0.049298894,0.03777508,-0.025656322,0.030147707,-0.029475143,-0.029061746,0.06702111,-0.02713613,0.02419077,-0.04091008,0.005488695,0.083602235,-0.010144925,-0.036453005,0.074070856,0.06338106,0.05834744,-0.012616992,-0.011768335,0.122579485,0.008628741,0.011797433,0.003830886,-0.0042107925,-0.04490665,0.039454166,0.016044406,-0.07702744,-0.06885953,-0.031643692,0.022318667,-0.046176568,-0.0012923545,-0.01898484,-0.12662694,-0.021347037,-0.00043444897,-0.033144016,-0.06575818,-0.028202977,-0.024026837,-0.018742014,-0.03001759,-0.048052195,0.039098453,0.025144843,0.017703118,-0.045688108,-0.01958424,-0.003828908,0.069614366,-0.064151905,0.046640642,-0.04232883,0.01955775,0.036271375,-0.018678451,0.09071451,-0.0030359998,0.01709545,0.03835104,-0.032148384,-9.044309e-34,0.011674718,-0.042362824,-0.020675123,-0.019220823,-0.049391873,0.027774906,-0.059690658,0.021148054,0.034592416,-0.005714465,-0.01109039,-0.042950574,0.022363264,-0.06093303,0.0026371344,0.066030465,0.0429537,0.117145225,-0.07647463,-0.03306516,-0.05691817,0.09773212,0.041333374,-0.030461624,0.06512423,0.015797628,0.07409143,0.0790548,-0.067991875,0.07020794,-0.009671932,-0.054751255,-0.06062718,-0.01140674,0.006465131,0.057149827,0.008114633,-0.040217705,0.03962377,0.02892638,0.020291736,0.07167427,0.00572215,0.019241363,-0.02372591,0.019403681,-0.049809214,0.082316354,0.03794542,-0.06294463,-0.012108962,-0.00577372,0.07591297,-0.00061873416,-0.04536133,-0.0011165516,0.074159764,-0.007521334,-0.035580497,-0.0237505,0.023754496,-0.06756509,0.05416443,0.061531786,-0.052991834,0.10639676,0.020022793,0.036011018,0.0431939,-0.04024562,0.01500764,-0.0056483373,0.062517434,0.12583469,-0.06679517,-0.032310087,-0.049391255,-0.06521875,0.025989927,0.040483583,-0.014769888,0.038571373,-0.075264536,-0.08570001,0.014662949,-0.0037560978,0.04479769,0.13712502,0.07091683,-0.006301117,0.0029480094,0.010564624,-0.039717156,0.08002884,0.025616629,-2.8660628e-08,0.069743134,-0.114804216,0.023828542,-0.057066422,-0.020607566,-0.029259767,0.049683984,0.0063382145,0.05858795,-0.019652473,-0.022465728,0.09864814,-0.010708929,0.018030263,-0.01825139,0.015213139,0.06945339,0.054689396,-0.044971548,-0.057335705,-0.013670039,-0.041095555,-0.10220446,0.022217968,0.013933127,-0.014798484,-0.0467433,0.07331263,0.03101676,-0.057178285,-0.039830416,-0.008033826,0.0028033806,-0.03930091,-0.082942516,0.14605208,0.04481539,-0.08180995,0.055254865,-0.026166366,-0.080027685,-0.04674575,0.06773779,-0.032180928,-0.030498095,-0.039514136,0.06347519,0.015769819,0.056116074,0.017022548,0.046896413,-0.02325899,0.023222217,-0.045987617,-0.11161907,-0.0099608,0.051547043,-0.033279978,0.040775873,0.013971667,-0.033472523,0.031832162,0.15380353,-0.022648958 +2.4.1.276,The reaction proceeds in two steps with the monoglucoside as an intermediate.,384,1.0,-0.051427122,-0.00822252,0.015394172,0.029499823,-0.010441858,-0.00505603,-0.074286416,0.030123044,0.043646265,0.04166631,0.043231867,-0.001414172,-0.08592325,0.032800563,-0.016720006,0.059223384,-0.05235082,0.03639222,-0.019426193,-0.038201034,0.010112001,-0.105235256,0.043375105,-0.0050540394,0.095920004,0.07636766,0.01417154,-0.034801528,0.058042802,-0.029310916,0.037843868,-0.019419612,-0.01870114,-0.018434424,-0.0566715,0.08017221,-0.05506041,-0.0057943976,0.02165149,-0.0098509025,0.036752272,-0.031022763,0.016369179,0.010076685,0.007495505,-0.004272425,-0.023347734,0.03340768,0.03177768,0.010371122,0.03990281,-0.086320825,-0.052008007,-0.005855802,-0.007265386,0.09080701,-0.08292969,0.032166287,0.03605342,0.022889,0.0014555631,0.011199642,-0.12317535,0.036769755,0.022310892,-0.050517492,0.047006696,-0.084937565,0.0093233315,0.05309853,0.010515297,-0.02908147,-0.042093024,-0.10416888,0.06517516,-0.044241,-0.014683928,-0.030470323,0.05728102,0.03260148,0.075763784,0.031409293,0.035829145,0.043321025,0.01850028,0.018854046,0.007704495,0.013997877,0.009598813,-0.000320348,-0.012260237,-0.038348895,-0.027733559,-0.00836791,0.0041785385,0.030760793,0.021540474,0.031096393,0.06203135,-0.003839578,-0.01770403,0.00077975035,-0.011104025,-0.10051703,-0.06790335,0.025596881,-0.0026775224,0.09201387,0.0009115329,0.05465982,-0.013093955,-0.043663185,0.046884667,0.033646137,-0.03561147,0.13695519,0.00033460694,-0.022630675,0.011172491,-0.055891458,0.031912375,-0.02947818,-0.011134554,0.037374344,-0.12589388,0.04394734,0.027442422,-2.2666742e-33,0.075686835,-0.026091408,-0.0069961464,0.02233644,-0.013805774,0.050109282,-0.041036766,-0.06839446,-0.09378914,0.038451444,-0.068726085,-0.06284445,0.0073510273,0.10560956,-0.08636496,-0.052348025,0.020436915,0.03158459,0.04407301,-0.018953402,-0.0031426419,0.07515555,-0.03469335,0.038417153,-0.018354427,0.0123357,-0.09117351,0.045956735,0.029697262,-0.020603694,-0.025649935,-0.0059847957,-0.1645086,0.059774127,0.018444244,0.004042762,-0.092027746,-0.05177002,0.027157271,0.02354321,-0.032199446,0.014512556,-0.053326234,-0.04019551,0.059810027,-0.05135204,-0.031552665,0.041727304,0.04926098,0.07069245,0.058302592,0.044794023,0.022631248,-0.0018968815,0.009895068,0.033025254,0.02966595,-0.005718947,0.0044689444,0.03575269,-0.0018632221,0.10120816,-0.034590542,0.039802607,-0.015447189,0.07856913,-0.12241661,-0.0053196633,-0.0019339458,0.0032458627,0.0053941947,0.010780641,0.002170927,-0.026256016,0.055821374,-0.00020746891,-0.010774567,0.006476392,0.039527513,-0.007796809,0.025781324,-0.013408222,-0.0008724549,0.0709759,-0.056288023,0.022595277,-0.04055628,-0.10821145,-0.030129027,0.094734296,-0.0235089,-0.044551734,-0.017473238,0.04075474,0.1006186,-1.1395603e-35,0.09240076,-0.08489473,-0.036837958,-0.08477877,-0.11032884,0.018557446,0.020206492,-0.12521538,0.055243675,0.036647636,0.0587489,0.02530948,-0.070730254,0.051409185,-0.038387597,-0.037783694,0.04658487,0.07700599,-0.026508758,0.02562807,0.038287874,0.11224884,-0.00022498528,0.067035586,0.04559391,-0.061521973,0.04784582,0.028984852,0.042546812,0.057457615,-0.008513552,-0.08078858,-0.04522383,0.017721979,0.05037518,0.00894476,0.015826773,-0.016244527,0.004478287,-0.046272166,-0.004275176,-0.04452858,0.053422045,0.08684685,0.13759205,0.018636867,-0.048422225,-0.004267919,-0.11043083,-0.08794732,-0.07329554,0.0047267466,-0.033692334,0.02261598,0.011938925,0.044049475,0.06958522,-0.07741806,0.07621197,-0.13531587,-0.039281853,-0.04704044,0.039796714,-0.092086285,0.047696456,0.027367786,-0.08229314,0.061611865,0.042435996,-0.01621173,0.047416996,0.011917252,0.007757175,-0.03491375,0.023585929,-0.08691866,0.010103647,-0.09006747,0.059242554,-0.11276366,-0.045928374,-0.0032864213,0.025259877,-0.063010804,-0.0011391906,-0.116151646,0.0007403809,0.04394462,-0.030310549,0.035149753,0.03679989,0.014833616,0.053152684,0.08598144,0.089257754,-2.177632e-08,0.0007054417,0.012797538,-0.040550344,-0.021546056,0.013648139,0.07944881,0.0201787,-0.017392386,-0.0379027,-0.059221584,-0.04532509,0.10638334,0.10385628,0.047605343,0.00876004,0.037632857,-0.047372486,-0.08473259,-0.03176845,-0.052222975,-0.078085996,-0.045488987,-0.007093289,-0.019329442,-0.06684513,-0.071608484,0.058818467,0.05581632,-0.0055787168,-0.00402379,0.012767062,0.011791032,-0.049998734,-0.015753701,0.065544076,0.04592275,0.021421352,0.03921891,0.06441699,-0.06490153,-0.008921996,-0.008032116,0.022644898,0.062025808,0.004379882,0.005896387,0.0016282757,-0.04620461,-0.033983313,0.10627675,0.034438502,-0.049579218,-0.016884468,0.028645946,-0.058819693,-0.056348406,-0.018844372,0.015219578,-0.002290478,-0.04495235,0.00019442535,0.016691234,0.109165296,-0.018366318 +2.5.1.96,Requires Mn2+. Typical of Staphylococcus aureus and some other bacteria such as Heliobacillus sp. ,384,1.0,-0.024353037,-0.055680476,-0.018738993,-0.0022515568,0.023874773,-0.057912447,-0.030344253,0.046605155,-0.04415948,0.022130875,0.047952943,-0.072444595,0.057894807,0.110933326,-0.036485214,-0.036365036,-0.05995563,-0.047046416,0.024052719,0.05955526,0.07744184,0.0881089,-0.036197476,-0.11057781,0.016469764,0.077717766,0.021329232,-0.055928208,0.03217106,0.014126377,-0.04054584,-0.006038482,0.0711454,-0.08698618,0.043877568,0.07243555,-0.011519578,0.0013533798,0.012260918,0.0070334715,-0.018470438,0.021971835,0.082566835,-0.008135087,-0.0185791,0.021118425,0.09125545,-0.07719511,0.0026088278,0.017562697,-0.024529506,0.019437639,-0.041913148,0.08295268,0.01077205,-0.04870112,-0.115218796,0.01906936,-0.059033167,-0.015965624,-0.04500786,-0.07508373,0.038059585,-0.010277708,0.058249123,0.010524708,-0.017150266,-0.0469705,0.04974829,0.07032333,-0.0006105059,0.02941403,-0.032300044,0.090188116,-0.020319996,0.017513862,0.05677995,-0.06420707,0.048222903,0.01705412,-0.103213124,0.04091268,0.059167143,0.10423765,0.08832641,0.09102616,0.018188477,0.031163104,-0.083527215,0.06875322,0.025342396,0.02751182,-0.004279351,0.0033451829,0.0066612214,0.002691213,-0.02446745,-0.0060856286,-0.010560995,-0.022919718,-0.06867131,0.020781064,-0.07313001,0.013916602,0.056502707,-0.09972469,0.023921035,-0.012610371,-0.018854143,0.061710898,0.13035208,0.07110472,-0.036001507,-0.077110946,0.010784036,0.02818585,0.05057673,-0.10638583,-0.05976561,-0.0059405533,-0.010723328,-0.0497802,-0.038869444,-0.020367907,-0.054389697,-0.008321918,-0.0090192715,3.0056292e-33,-0.020439096,0.0054085734,0.047901355,-0.0076491428,-0.01875302,0.0037878728,-0.072955504,-0.0587292,0.104304254,-0.10058267,-0.06908372,-0.05453986,0.025167827,0.04325669,-0.020191208,-0.016569674,0.02341204,-0.029408965,0.079476036,-0.057266198,0.009958823,0.02205868,0.015017869,-0.0077993833,-0.0018306391,0.038748592,0.116687976,-0.04131046,0.05284532,-0.016017292,0.011013758,-0.09010365,-0.041355554,0.007950947,0.059392847,0.07575176,-0.11287696,0.001204259,0.007114282,-0.0062898896,0.022447873,0.07930963,-0.0549681,0.06486368,0.052236624,-0.08504234,-0.03540055,0.05129253,-0.05039069,-0.0004663331,0.009332776,0.03873783,0.023174431,-0.0029132112,-0.03279296,0.005793915,0.08824337,-0.007432128,4.083064e-05,0.08866702,-0.029331055,0.028785482,0.028249973,0.14175163,0.056068394,0.026914611,-0.039778188,-0.03558222,-0.040201798,-0.024404619,-0.0009401938,-0.14163192,0.0019702022,0.004375939,-0.088007584,0.010705254,-0.004264023,-0.018413575,0.04251626,0.0015047686,-0.07060156,-0.05696301,-0.0044753477,-0.0375054,-0.13927546,-0.0046520773,0.00021479787,-0.06838522,0.022510603,0.03402296,0.07175563,-0.040532902,-0.0626691,0.03375879,-0.042641126,-5.459944e-33,-0.0017145779,-0.04335736,0.049078204,-0.07125447,-0.07809744,0.089735076,0.006622373,-0.11289536,0.040157553,0.033385433,0.038869083,0.03924825,-0.032387175,0.015705502,-0.057027508,0.012371694,0.03280114,0.096118964,0.052104596,-0.0144705875,-0.008070989,0.14455083,0.034472473,0.052746024,-0.0072241547,0.07680928,-0.06555247,0.051717877,-0.055702124,-0.032286033,0.0019167246,-0.03358577,-0.06559173,-0.06955945,-0.049499527,-0.032772437,0.011553,-0.04164964,0.02116858,-0.037403446,0.06503842,0.0037178735,0.010957315,0.11155875,-0.035428014,-0.016588585,-0.020552887,0.021784065,-0.000275571,-0.007878593,-0.0145173045,-0.013402564,-0.063514896,-0.051357068,-0.0073352316,-0.0038198181,-0.02770255,0.019668685,0.029120108,-0.051808726,-0.01260491,-0.071706995,-0.013857196,-0.009041237,-0.012788316,0.0019855427,0.056698743,0.0032934386,0.013406383,-0.029244741,0.015127528,0.06637082,0.051895726,-0.057606198,-0.0707163,-0.03507918,-0.058461532,-0.009192163,0.06741999,-0.06287301,-0.047420032,0.0074421945,-0.0035130703,0.026492473,0.03880537,-0.09973458,0.05451376,-0.011825537,-0.061271936,0.048903234,-0.027915567,-0.02420228,-0.014323378,0.03941863,-0.012938835,-2.9567891e-08,0.03072954,-0.060153075,0.047510143,-0.036506146,-0.058189422,0.007607105,-0.06735711,-0.0111300545,0.117870666,0.0058683525,0.030126587,0.014608777,-0.011485468,-0.051450983,0.02993105,0.0021953923,-0.021466723,-0.018631432,-0.051370148,-0.10687843,-0.07729188,-0.04469058,-0.04058546,0.07625001,0.03758448,0.048475515,0.045180216,0.05395501,0.0017747802,-0.039778437,0.015313023,-0.004142829,0.010233617,-0.032271225,-0.08237918,0.054240335,0.06327187,-0.031001214,0.015342594,0.0069185495,-0.05410043,0.044483267,-0.024119219,0.042449545,-0.05899119,0.016244134,-0.08720443,0.07521658,-0.032355044,-0.05307607,0.049571358,-0.05704446,0.029529743,-0.037627745,-0.1257088,0.091313586,-0.0041020317,-0.04491429,-0.020701112,0.023685958,0.06184534,0.029048387,0.08720717,-0.0042229653 +2.8.1.10,H2S can provide the sulfur in vitro. Part of the pathway for thiamine biosynthesis.,384,1.0,-0.058650147,0.03552172,-0.111151494,-0.018815398,-0.020475393,0.029325664,-0.06191215,0.021290857,-0.011985158,0.011177195,0.01459863,-0.004330296,-0.026159678,-0.0028919484,0.022109656,0.07189177,-0.025484588,0.013533893,-0.025805226,-0.0682437,0.04527392,0.08246462,-0.06604901,-0.002909027,-0.05986936,0.066182286,0.03500975,-0.022805067,-0.011570401,-0.05011069,-0.082759,-0.017045183,-0.0024986484,-0.0754459,-0.06527167,0.05464358,-0.03522066,0.03653377,0.027767478,-0.079210244,0.046142664,0.0067578484,-0.08143808,0.019136189,-0.05735422,-0.04879694,0.07376181,0.023964424,-0.035765707,-0.013435898,-0.0645265,0.04036536,0.010662966,0.011163526,0.011459954,0.035170317,-0.0029676736,0.017728366,-0.008433491,-0.03768975,-0.02720179,-0.04865785,0.015711028,-0.047747064,0.08770762,-0.0626624,0.020362092,-0.025092984,0.005740885,-0.026422435,-0.053774368,0.009005754,0.006339664,0.035999607,-0.044931885,0.050987408,0.02356845,-0.04363359,0.064484194,0.034752168,0.03377225,0.00011423542,0.08355688,0.120431,0.056175552,-0.03779092,0.0110624945,0.0103708645,-0.03703962,0.016559912,0.011986651,-0.04959728,0.021548362,0.034858927,-0.073561594,0.034450322,0.024964215,0.070936695,0.014943747,-0.06162389,0.027808947,-0.040410463,-0.08501167,-0.04679897,0.0035991578,-0.007212855,0.027090788,0.07288112,0.0013189147,0.08213517,0.0035237581,-0.016658133,-0.005143292,-0.0018540027,-0.026115462,0.11117267,0.06479299,0.031689983,-0.09812349,-0.048348457,-0.032509062,0.06516663,0.051309843,-0.018198896,-0.042531908,-0.084184796,-0.10505224,-1.4549092e-33,0.077638045,0.11063967,0.05217507,-0.020265268,-0.019077605,-0.035573825,-0.0793249,0.05837312,0.075871095,-0.071690716,-0.056608222,-0.10296836,-0.015708683,-0.056414492,-0.05962045,-0.066756465,-0.040650353,0.012165093,0.08569846,-0.030388197,-0.095389314,-0.001332516,-0.053733923,-0.026065068,-0.011988256,0.028567646,0.10445728,0.06398797,-0.013240303,0.0054607326,0.086036086,-0.09695667,-0.02475386,-0.019846607,0.08875465,-0.008513039,-0.03758097,0.06184479,-0.040971987,-0.06421908,0.068577036,0.042990148,0.009908332,-0.03616224,-0.015317636,-0.046235662,-0.059269726,0.053777352,0.015735077,0.046108216,-0.04298916,-0.014241198,0.09617508,0.004901156,-0.023152927,-0.025952758,0.019700713,-0.022508474,0.04648737,0.04293737,-0.052188177,0.03120703,-0.002417488,0.08141916,-0.0944832,-0.01259353,-0.11883536,0.013763369,-0.004118387,0.045507807,0.032592855,-0.0053680525,0.080751844,-0.030406239,-0.040915594,-0.0037718895,0.008781418,0.0363838,0.03489057,0.04217788,0.039017726,-0.047287595,-0.019711033,0.010324497,-0.047205504,-0.09260933,-0.020517344,-0.01723696,-0.011745091,0.033347014,0.0007160967,-0.023870606,-0.04924287,-0.0010743667,0.04361573,-9.262925e-34,0.023143763,-0.019658953,0.083035484,-0.07992311,0.018905846,0.030063456,0.033717353,-0.019772956,-0.005500928,0.016438566,0.048531536,0.06615449,0.033324506,-0.03724549,-0.033711057,0.019569749,0.051531315,0.04440247,0.022467071,-0.022634227,-0.021704143,0.052830983,-0.029913444,-0.023541128,0.0038820666,0.02554635,0.050198205,0.016556934,0.043243576,0.109045655,0.024032382,0.004549334,-0.0792738,-0.007680018,-0.028285088,-0.040796347,0.006833371,0.010935508,-0.010363071,-0.026136942,-0.060332436,-0.044678394,0.06617833,0.13125108,0.026583118,0.048580695,0.015497786,-0.025579976,-0.040446974,-0.018595908,0.07771723,-0.00445234,-0.034945156,0.051699173,0.022468373,-0.020414267,-0.016439606,-0.007982177,0.031601883,-0.02136987,-0.044842977,-0.066449076,-0.016638376,-0.0588284,-0.06335887,-0.015006289,-0.037049066,0.000771028,0.050436437,-0.008151199,0.036043182,0.01729381,0.034866534,-0.021279756,-0.073796995,-0.003541917,-0.048949532,0.020389732,-0.03752647,0.020573182,-0.021649646,-0.0004268696,0.008574374,-0.06417702,0.054482535,-0.09440862,0.036108766,0.079657696,-0.089631796,0.026788164,-0.061831012,0.022375466,-0.06852258,0.05208868,0.028113432,-2.1824448e-08,-0.07797081,-0.10688121,0.0805933,0.03840209,-0.019451814,0.08556569,-0.04763139,0.08661293,0.12392072,0.033925746,-0.054631986,0.10609399,0.025472155,0.029096652,0.055908196,-0.014594486,-0.013781222,-0.0017703652,0.0029785477,-0.037293904,-0.072050564,-0.027476925,-0.052088536,0.022457654,0.060943305,-0.05246344,-0.017137084,-0.14141771,-0.031854354,-0.05784862,0.08345594,0.0027756575,0.011236073,-0.059955236,-0.024626626,0.019961877,0.06903138,-0.06298182,0.0037314796,-0.059696797,-0.0060848985,0.060428303,-0.102742426,0.07904806,0.057002373,-0.013760394,-0.031884585,0.15178381,-0.1325133,-0.05722024,0.001339212,-0.00510656,0.0007225934,-0.093523435,-0.022640143,0.097348765,0.08005819,-0.022678511,0.020307066,0.06718927,0.10634142,0.03897246,0.09402705,-0.01768894 +3.1.4.54,This enzyme is involved in the biosynthesis of anandamide. It does not hydrolyse phosphatidylcholine and phosphatidylethanolamine [1]. No transphosphatidation [1]. The enzyme contains Zn2+ and is activated by Mg2+ or Ca2+ [2]. ,384,1.0,-0.0062977914,0.013003933,-0.111731,0.024402434,-0.042624887,0.061268844,-0.016151931,-0.02816627,0.0066417223,-0.023130853,-0.04086331,-0.06933235,-0.020266391,0.034236915,-0.06146195,0.08760549,0.02166417,0.008747338,-0.05364466,-0.0339032,0.086403206,0.06266787,-0.00692925,0.0052767256,-0.0047961236,0.038449917,0.05370876,-0.021632219,0.06761967,0.039456546,0.014290107,-0.07032013,-0.011863034,-0.023154,0.0006350312,0.05023387,-0.077856444,0.00124402,0.0631663,0.010462374,0.15317085,0.06785731,-0.04057958,-0.027681263,0.049124878,0.0020506366,-0.016113091,-0.036554035,-0.026743138,-0.04528558,-0.036269046,-0.07955852,0.025458965,0.07301542,0.006234089,0.041276395,-0.07974576,0.039210167,-0.031326197,0.06922736,0.01672036,0.043258674,-0.0006325517,-0.01874322,0.08165582,-0.029691435,-0.0770323,-0.039946616,0.053908028,-0.08822175,-0.047957227,-0.07471068,0.017934721,-0.05258641,-0.049942773,-0.023476275,0.0035748568,-0.04559171,-0.021599116,-0.053839836,0.03209117,-0.06176994,0.08406454,0.08437661,0.033574793,0.05146504,0.00037372322,0.05720672,0.026625123,0.05405534,0.04696826,-0.011800579,0.057562675,-0.02207826,-0.015539955,-0.0012845816,0.014307665,-0.01653363,-0.039199244,0.0137257045,0.028790057,0.10917384,-0.05473689,-0.08707616,-0.07988633,0.05704012,0.02375761,-0.0043042013,-0.008603208,0.022297315,0.021998826,-0.02612255,0.0674723,-0.016794119,0.025018115,0.08967707,0.0046098772,-0.013896213,-0.041995075,-0.03770743,-0.008257822,-0.035396017,0.053076945,0.038224895,-0.052311204,0.017869122,-0.091751836,5.0800575e-33,0.0066664075,0.0136449365,0.004809325,-0.02579954,0.035406597,0.009639652,-0.028531397,-0.02109036,0.025126541,-0.11407344,-0.03199156,-0.0640474,-0.004435447,0.014356651,-0.04955674,-0.031227024,-0.03629735,-0.02615545,0.14229636,-0.012116229,-0.0180576,0.015673818,-0.08340122,0.048606895,-0.010856831,0.0686585,0.026139729,-0.046153948,0.036776505,-0.030406818,-0.017636282,0.0022754981,-0.17660855,-0.033308264,0.007384472,0.070919685,-0.0036300898,-0.0013330309,-0.05035359,0.0106748585,0.011114418,-0.054928318,-0.020579476,-0.01976829,-0.03871679,-0.011559617,-0.098691344,0.08644175,0.10386002,0.027822318,0.031023698,-0.031859625,0.048473816,0.05098353,-0.08696496,-0.03032476,-0.0063584754,-0.0072862906,0.045563802,0.027760198,0.0019899383,-0.07150441,-0.053632703,0.045359727,0.016773134,-0.0086182505,-0.06863237,-0.055373926,-0.028979732,0.058381304,-0.07034687,0.02027568,0.061946042,0.038528424,-0.008600048,-0.0880094,-0.026790803,0.012442458,-0.02433217,0.08100461,0.037653774,-0.019659026,0.060577706,0.021382421,-0.0047527608,-0.03821842,0.013052801,-0.02998142,-0.02235508,0.031052887,-0.0029061767,-0.029338222,-0.020854458,0.12087947,-0.021830961,-5.1433414e-33,0.04234608,-0.1427858,0.030262504,-0.04056427,-0.009069613,0.01689989,-0.0036589364,-0.009120639,0.067162074,-0.032858577,0.10207255,-0.0028889424,0.073208004,0.035675857,0.020748904,-0.018146735,-0.038580284,0.13272037,0.020430852,-0.04553101,0.0024629484,0.09032417,-0.06280325,0.013004127,0.04784691,0.022891963,-0.01039062,0.077759184,0.029206766,0.1110114,0.03339438,0.04760692,-0.09578059,-0.05724487,-0.10030703,0.1480762,0.004583687,-0.029234998,-0.060225543,0.05683044,-0.03617766,-0.022000356,0.040761832,0.06005526,0.06276363,0.09330413,-0.02360068,0.015571523,-0.024514124,-0.015148321,0.08692295,0.028068516,-0.04492623,0.050610196,0.07275121,0.015082393,0.00964546,0.034604557,-0.02906112,-0.10542571,-0.034113687,-0.011032233,0.010994033,-0.020665972,0.018047955,0.03854789,0.08092811,0.055435225,0.060873315,-0.027466055,0.10801927,0.008836959,0.048811812,0.0785276,-0.017764973,0.0036954354,-0.061448637,0.008382144,0.020195795,-0.0533613,0.040698342,0.039517034,0.04481041,-0.036725324,0.020278472,-0.016906748,0.0076838606,0.096231245,-0.05036467,-0.016468875,0.001090258,-0.026249312,-0.060797233,0.018866068,-0.020231586,-3.5758376e-08,0.011498059,-0.14989018,-0.008939979,-0.07300779,-0.055332158,0.040983673,0.07987008,-0.0026534349,-0.05051946,-0.059338164,-0.012308826,-0.038517457,-0.035809994,0.07944496,0.010265969,-0.009012464,-0.011081257,0.081021,-0.008891841,-0.09835217,-0.08594859,-0.026337842,-0.04286802,-0.004981227,-0.035461847,-0.06379796,-0.01466195,0.056403764,-0.022713166,-0.010960182,0.055236965,0.0023419072,0.060723048,-0.06767678,-0.045457758,0.044600576,0.04160867,-0.03749434,-0.0053659026,-0.032011386,-0.033515733,-0.06896029,0.0042069093,0.00017870008,-0.02082752,-0.045570694,0.001598276,0.0004641892,0.044374436,-0.03435099,0.05276386,-0.011053211,0.050355244,-0.08037064,-0.09835965,-0.046521362,-0.008217068,-0.036711253,0.0043943576,-0.063226305,0.041849665,0.015287983,0.13651003,-0.042631418 +4.2.1.131,"In Rubrivivax gelatinosus [1] and Thiocapsa roseopersicina [2] both products are formed, whereas Rhodobacter capsulatus [1] only gives 1-hydroxy-1,2-dihydrolycopene. Also acts on neurosporene giving 1-hydroxy-1,2-dihydroneurosporene with both organism but 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene only with Rubrivivax gelatinosus.",384,1.0,-0.04074568,-0.09416602,-0.06228735,-0.00970491,-0.04309901,-0.0026576796,-0.012014091,0.06603078,0.017526207,-0.012929234,-0.016030107,-0.029194957,0.08818911,0.071569666,-0.09498649,-0.017534161,-0.030809397,0.006951195,0.025753444,0.11862378,0.119085625,0.010900413,-0.0692261,-0.008791876,0.027734067,0.009132817,0.018683463,-0.020122264,-0.0283548,-0.09296129,0.029290078,0.015728349,-0.037355904,-0.113716654,0.049467504,0.045476332,-0.023770703,-0.0010096916,0.10152928,0.062255505,-0.0050603235,0.015913432,-0.024072064,0.055191565,-0.043492537,0.019565724,-0.02234195,0.13393992,0.074514605,-0.043518417,-0.08836844,-0.073075846,-0.07437197,0.08982128,0.02810102,-0.018500626,-0.10034766,0.010742071,0.00022656257,0.027998924,0.04477981,-0.043953523,0.038915247,0.022694493,0.0050119376,-0.0709909,-0.0012648831,-0.03694897,-0.011783285,0.024238626,0.01511083,0.038459066,0.04118482,0.027526129,-0.02851812,0.044141818,0.014297579,0.024363471,0.054335725,-0.009469946,-0.055753212,0.012698078,0.009110631,0.06309894,0.0037144406,0.0075114546,0.06586699,0.038610354,-0.026173562,0.03247876,0.03690342,0.05743564,0.024104543,-0.07522227,-0.10782425,-0.04262336,0.009766726,0.08710782,0.024593048,-0.05049236,-0.049392667,-0.054646697,-0.011373343,-0.09173153,-0.018197406,-0.029772125,-0.045492195,-0.05289564,0.029912671,0.024666965,0.011820643,0.032879308,-0.056166876,-0.036206055,-0.07174695,0.10085015,0.09304128,-0.03367165,-0.06107355,-0.09939159,-0.028963922,-0.100998245,0.09867646,-0.05556373,-0.04496974,0.006870648,-0.072946146,8.598371e-33,-0.048097,-0.036076203,-0.091208994,0.032509565,0.014187976,0.08156826,-0.09084228,0.06588829,-0.03632404,-0.07037118,-0.09536321,0.031168174,0.04686426,0.03452381,-0.05223548,0.011288643,0.019999433,-0.012962676,-0.001575063,-0.059300233,0.038554955,0.11034187,-0.029699666,0.023042709,-0.021538751,-0.0005619219,0.0075179837,-0.08032101,0.040929247,-0.0131042795,0.06779719,-0.09748735,-0.029025735,0.05840406,-0.0060070986,0.011948021,-0.07535366,-0.0950281,0.025618415,-0.042105723,-0.0059967423,0.036459416,-0.01703649,-0.067001425,0.023604952,-0.0068202633,-0.051669627,-0.016653206,-0.007487541,0.00011135362,-0.011532008,0.07072229,0.108792305,-0.030364081,-0.055192806,-0.06065575,0.0137726255,0.05753662,0.053367656,0.0040055793,0.035600413,0.08650018,-0.016150443,-0.036013324,0.006477316,0.09255878,-0.012030648,0.02018869,0.0007704278,-0.004632085,0.0017791934,0.008457375,0.009436014,-0.012595197,-0.013112417,-0.06276663,0.046242952,0.0012574343,0.0050938195,0.001582727,-0.04171682,-0.017738359,0.08586627,0.012733152,0.009861727,0.0153901195,0.036411293,-0.014545549,0.012233802,0.059925593,0.051191512,-0.036046095,-0.087553546,-0.01311869,0.036048107,-7.956123e-33,0.016685806,-0.09431266,0.052348398,-0.012397982,0.008820946,0.04489538,-0.0028398512,-0.0068026325,-0.023412148,-0.119736314,0.07756079,-0.018245766,-0.08255919,-0.0034029295,-0.015979571,-0.011894516,0.053885035,-0.041036457,-0.021654062,-0.05958857,-0.11544203,0.07927908,-0.029411959,0.010853969,-0.009968555,-0.0030863828,0.027378967,0.018583622,0.018102357,0.06083797,0.016989198,0.032540202,-0.031426046,0.02425304,-0.07259951,0.021365734,-0.057245262,-0.060736965,0.04941902,0.012562378,0.09326897,-0.06150996,0.02943324,0.045621037,0.04101042,-0.015958149,-0.05626342,0.04435071,-0.022456016,0.020556517,0.04762832,0.016402291,-0.062116846,0.039736096,0.0122810565,-0.014698975,0.017892214,0.000579339,0.05696561,-0.04663506,-0.00028437632,-0.09240855,-0.046041973,0.012326768,0.03001315,0.12913947,-0.02594301,0.09185339,-0.0035689448,-0.021543464,0.118288875,0.022221534,0.021137023,-0.025799122,-0.0042742975,0.035823468,-0.020451957,-0.05652096,-0.039412677,-0.03268727,-0.019586826,-0.009003669,-0.020456841,0.041872643,0.0287358,0.025575008,0.011391717,-0.040312834,-0.068795495,0.014221108,0.03986856,0.0079765655,-0.033037256,0.048745602,0.16005656,-4.661595e-08,0.08234166,0.002282055,0.05553244,-0.05325272,0.04762619,-0.05649517,0.028277157,0.05952254,-0.0037714427,0.057770774,0.0037333467,0.028863981,-0.023271317,-0.0077082496,0.086672805,0.050629977,-0.07747113,0.050625358,-0.0068552317,0.030713754,-0.05173476,-0.028218482,-0.054469366,0.0071071573,-0.08283933,-0.0073233894,0.02524488,-0.08756148,0.02259654,-0.07122749,0.07530626,0.034357905,-0.012613519,-0.029047959,-0.054749053,-0.0064887907,-0.05177579,0.059655048,-0.031816434,0.018433955,0.023494164,-0.012909444,-0.025598262,0.050980672,-0.045389216,-0.04499789,-0.005539906,0.018661862,0.043341868,-0.023851724,0.020293597,0.055901825,0.05330826,-0.10159983,-0.12234904,-0.0033377383,-0.0027603004,0.009142307,-0.026061885,0.045619972,-0.007717441,-0.040022448,0.20516805,0.03682463 +4.2.3.84,"The recombinant enzyme from ginger (Zingiber zerumbet) gives 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol, 10% alpha-eudesmol, and 5.6% aristolene. cf. EC 4.2.3.68 (beta-eudesmol synthase) and EC 4.2.3.85 (alpha-eudesmol synthase)",384,1.0,-0.063148454,-0.04135425,-0.08719379,0.017013919,0.047343694,0.02549381,0.052264832,0.07146103,0.031016804,-0.019443631,-0.024611808,-0.025933035,-0.035725005,-0.020297818,-0.10118485,-0.001301379,-0.02831133,0.002800783,-0.040487755,-0.029419856,-0.030911159,-0.04003726,0.06719032,0.042373084,0.06725543,0.0025704678,0.03938106,-0.06399654,-0.054567788,-0.098013915,0.007350835,-0.090804435,0.0784618,-0.07565376,-0.0898745,-0.022930628,-0.011756648,-0.14490739,0.03616808,0.03303204,0.048425496,0.031223807,-0.068578735,0.0039696936,0.0024240413,0.029758343,-0.018912375,0.047185306,0.0014391026,0.043764178,-0.05880028,-0.07249613,-0.024540083,0.044480965,-0.008018626,0.051997855,-0.060659528,-0.046603005,-0.021704651,0.07122356,0.03828726,0.029474901,-0.07858354,-0.01497344,-0.106321864,0.024578182,0.006691275,-0.09124304,-0.06494034,-0.011791391,-0.09673704,-0.06395581,-0.040898945,0.046734404,0.020343183,0.046733327,0.053988848,-0.031935662,-0.001738603,-0.0065588737,-0.01796048,0.025806746,0.011915489,0.030968398,0.07228941,0.048216537,0.04143436,0.0777248,0.09336256,0.06735188,0.06910543,0.033564452,-0.017969975,0.029145846,-0.028815152,0.06265201,-0.02281153,0.0007136108,0.06592049,-0.03640928,0.014147608,0.03709074,0.02003205,-0.061259694,-0.12575363,0.033860482,0.028230257,0.06857059,-0.019001465,0.04146363,0.031705722,-0.058744274,0.074672624,-0.056829285,-0.05625759,0.078367256,-0.008737151,-0.052812923,-0.011564475,0.02485656,0.049818303,-0.0059890836,0.048130553,0.08042694,0.020190902,0.03658716,-0.11748034,4.9406523e-33,0.0047332053,0.08193488,0.00052791316,0.07798896,-0.020092022,0.121471934,-0.1441743,0.065427974,0.008770657,-0.10163799,-0.11992411,-0.040030207,-0.020435164,0.0015581776,0.008437447,0.03765397,0.03434973,0.022916721,-0.00950098,-0.0034813008,0.014426514,0.02944411,-0.08154509,-0.020927357,0.018831683,0.026303193,-0.010432979,-0.023731748,0.007523024,-0.01909655,0.052232802,-0.065854855,-0.016970143,0.047554184,0.012339805,0.043871712,-0.021066893,-0.017627392,0.008863355,0.095150396,0.047260664,0.043409497,0.020903878,0.04967686,0.019281669,-0.057498273,-0.04224162,0.03102934,0.07758453,0.014483251,0.007052086,0.01158062,0.0664454,0.11971658,-0.03443006,0.10007483,-0.104101636,0.04579385,0.09889568,0.05027421,-0.07255775,0.124428615,0.071903735,-0.02035175,0.048608705,0.035855167,-0.008293789,-0.033023708,-0.1129244,0.08088481,-0.040038604,-0.022289025,0.10965226,0.03728816,0.00720375,-0.062294625,-0.017380353,-0.026548922,0.045475986,-0.0044138865,-0.066783346,0.013344347,-0.008119541,0.0049213604,-0.016485427,-0.052388918,-0.023027534,0.06989631,-0.014793156,0.050358333,0.12425105,-0.072617784,-0.084642515,0.011406524,-0.054169234,-3.2912027e-33,0.00048586732,-0.10586815,0.017222175,-0.040416397,-0.021081274,-0.005091684,0.021337437,-0.03263118,0.0403215,0.003973878,0.068676606,0.026811616,0.030244095,-0.0031360253,-0.03338894,-0.0003059267,0.020032128,0.089734316,-0.0016935854,0.009364647,-0.04891974,0.043032445,0.05399499,0.030296579,0.021173054,-0.015742367,0.052074406,0.06844799,0.06439809,-0.039843872,0.020230686,-0.018194903,-0.018358223,-0.13990687,-0.05999319,0.027705755,-0.009706253,-0.0045919186,-0.0048287446,-0.009717229,0.03573008,-0.029694013,-0.0172204,-0.010115085,0.107312284,0.08143918,-0.026941538,0.03625821,0.021394541,0.018498462,0.08039178,0.007931901,-0.019093165,0.028066596,0.0202488,-0.04621742,0.007241619,-0.005070567,-0.0012076211,0.04273267,-0.008705088,-0.004712224,0.08098123,-0.018369658,0.022254014,0.0018445663,0.031495612,0.13662049,0.0033172339,0.045456696,0.07105138,-0.021301003,-0.03457027,0.062044498,-0.010237339,-0.017401475,-0.019740282,-0.026929624,0.047599904,-0.042794887,-0.0054106824,-0.038285267,0.002162899,-0.019239366,-0.034342226,-0.032501712,0.023338594,0.042659666,0.024961207,0.005465474,-0.050020013,0.001683372,-0.0067761918,0.036287796,0.0632571,-4.2438412e-08,0.08725332,-0.06974275,0.02769771,-0.03724626,0.0007973228,0.031349834,0.025477136,-0.013566691,-0.06145581,-0.01951736,-0.014767078,0.092922635,-0.040336497,0.01772351,-0.009640788,0.00017383553,0.0085092075,0.075703435,0.0053283763,0.034099735,0.0138880415,0.06834753,-0.059920594,-0.056256913,-0.017030412,-0.077697076,0.082430206,0.030262006,-0.035545018,-0.07812315,0.022027854,0.009918759,0.05712161,-0.059856966,-0.08048037,0.00455832,-0.033726778,0.022305101,0.00032601997,-0.019659314,-0.03744337,-0.10374917,0.010947099,-0.043964274,-0.09702135,-0.011877802,0.0067706,-0.06548448,0.08629576,-0.048033305,0.0024370514,-0.011120132,-0.008066971,-0.102849595,-0.08088086,-0.015668796,0.010445074,-0.04906017,0.017693967,-0.07586827,-0.005201674,-0.046087224,0.075974494,0.021032581 +4.2.3.85,"The recombinant enzyme from ginger (Zingiber zerumbet) gives 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol, 10% alpha-eudesmol, and 5.6% aristolene. cf. EC 4.2.3.68 (beta-eudesmol synthase) and EC 4.2.3.84 (10-epi-gamma-eudesmol synthase)",384,1.0,-0.06452465,-0.043189015,-0.08778328,0.018556843,0.045350578,0.030390283,0.056185566,0.0761005,0.029644046,-0.026312385,-0.022547724,-0.018979017,-0.029987136,-0.017694628,-0.09948637,0.0004997826,-0.0196099,-0.0012784979,-0.03861514,-0.02954567,-0.031206293,-0.03956684,0.06622396,0.035522003,0.07272076,-0.002639432,0.036171276,-0.06135707,-0.055676877,-0.09508762,0.014456219,-0.088479385,0.07233017,-0.07791854,-0.086037286,-0.021167038,-0.011426903,-0.14235823,0.040177938,0.031534683,0.048651002,0.03434865,-0.065242514,0.0017040343,0.010537572,0.024466183,-0.018400077,0.04367719,0.0016401985,0.041197427,-0.06262262,-0.07003032,-0.023937741,0.04974761,0.00019308613,0.051512066,-0.06410919,-0.0507063,-0.024006955,0.07145987,0.037321363,0.028742092,-0.07890178,-0.017511243,-0.10457017,0.018239792,0.008672033,-0.091102235,-0.0627577,-0.011993499,-0.09912265,-0.06045117,-0.046372715,0.04135329,0.01699539,0.046526033,0.052687645,-0.026354142,-0.00196679,-0.00841582,-0.018224347,0.028348854,0.020838792,0.032811068,0.07347065,0.0434403,0.04887022,0.083009236,0.08808287,0.06712415,0.067567855,0.034088332,-0.015890688,0.028719436,-0.033547033,0.059047718,-0.031306647,-0.0043065543,0.06501165,-0.033313576,0.015737327,0.032187272,0.025434686,-0.06504244,-0.12155322,0.03897019,0.022480639,0.07001096,-0.01693419,0.03851289,0.033601366,-0.05346532,0.07352175,-0.05350001,-0.060088325,0.08067506,-0.009568799,-0.04972002,-0.01756005,0.025561063,0.04842215,-0.009098005,0.047903754,0.07341504,0.022090655,0.039521523,-0.120665945,4.990027e-33,0.0033854635,0.080371894,-0.001040114,0.07189333,-0.014438885,0.12353159,-0.14330146,0.07250786,0.010481352,-0.09426561,-0.121572375,-0.042458426,-0.017416691,0.0012660467,0.0031159958,0.0421864,0.026150076,0.023142934,-0.008942703,-0.006112994,0.009367162,0.032182362,-0.084398486,-0.019320715,0.02174742,0.021960633,-0.008019668,-0.023499055,0.009115706,-0.020872736,0.05672796,-0.06594052,-0.014023055,0.04651071,0.016358994,0.039561927,-0.020864528,-0.018116243,0.009586168,0.09411148,0.052889064,0.04305119,0.013974624,0.052721202,0.018900272,-0.054435965,-0.04169386,0.03224708,0.081930704,0.017142149,0.004069983,0.007881043,0.06544863,0.12388773,-0.037748,0.099828914,-0.10276098,0.053130694,0.103786275,0.04435546,-0.08097565,0.118531235,0.069676995,-0.023532286,0.047882017,0.033405796,-0.008266991,-0.03251598,-0.113173224,0.08217891,-0.039921038,-0.02188965,0.10477917,0.032844353,0.012838223,-0.070413575,-0.018330388,-0.025467848,0.055785794,-0.006309411,-0.06589556,0.015954742,-0.003109394,0.0014661234,-0.023068585,-0.054885954,-0.02716208,0.06540524,-0.014727995,0.050672255,0.12858993,-0.06568583,-0.08159058,0.0065971646,-0.052019157,-3.2320952e-33,0.00065866025,-0.10111573,0.016221963,-0.038785845,-0.013537492,-0.0059835874,0.03132697,-0.037696917,0.0390652,-0.0025050077,0.067380466,0.02991812,0.030111045,0.00096051424,-0.033524394,0.0016940349,0.017759055,0.094532736,-0.0038510815,0.010016322,-0.056251463,0.04520828,0.053358383,0.028426427,0.01762054,-0.009475305,0.054895878,0.06438989,0.069644056,-0.03204507,0.020117689,-0.01708463,-0.026136402,-0.138855,-0.05758329,0.021863537,-0.008136712,-0.0074266787,-0.0086329,-0.006092376,0.03459822,-0.02636213,-0.013357917,-0.007156362,0.10510324,0.08567052,-0.028915685,0.038409993,0.0182881,0.013563851,0.08008063,0.007928277,-0.022213368,0.030193973,0.016490066,-0.042948898,0.009403848,-0.007650598,-0.002714596,0.046208013,-0.013511421,-0.008799332,0.083541386,-0.018783323,0.025120543,0.008264284,0.039790776,0.13583633,0.0029385334,0.03911724,0.06843784,-0.02100931,-0.034479905,0.059910256,-0.012543094,-0.015602632,-0.026604056,-0.02090243,0.045004394,-0.0443602,0.00097572815,-0.036099892,-0.0017631628,-0.022519656,-0.034682468,-0.032797147,0.015847305,0.04931253,0.027844645,0.00058821077,-0.048092823,0.0068391743,-0.0060324986,0.037278585,0.06612583,-4.3950052e-08,0.088191286,-0.07685572,0.029608596,-0.0353,0.0019638583,0.029888555,0.027823085,-0.014018965,-0.062873125,-0.019310419,-0.010238318,0.09895355,-0.04925788,0.016069114,-0.011676178,-0.0020299302,0.0056024995,0.07574454,0.0040520327,0.037589837,0.010256939,0.06773774,-0.062843226,-0.055625126,-0.018507235,-0.07461157,0.07981085,0.03448929,-0.027987184,-0.07973264,0.027833804,0.013323321,0.057236087,-0.05859187,-0.085972056,-0.001784383,-0.028524473,0.024511619,0.005605311,-0.02350314,-0.035827108,-0.10327758,0.007955339,-0.043593403,-0.099744946,-0.016500076,0.005364019,-0.06152888,0.07959351,-0.04333158,0.0032140568,-0.008029428,-0.013923599,-0.10415019,-0.08257752,-0.013254162,0.010398161,-0.050213084,0.014512137,-0.07480262,-0.007572861,-0.04373194,0.07304188,0.021170877 +5.4.99.45,"The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC 5.4.99.12, tRNA pseudouridine38-40 synthase) [1]. In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu) [2]. ",384,1.0,0.059630685,-0.116104975,-0.06912526,-0.03364578,0.010207885,-0.0051221927,-0.027138758,0.009834435,0.019675074,0.06993921,0.049140256,0.03125928,-0.03704601,0.12772705,-0.0051764916,0.049020626,-0.06334065,0.0050365617,0.08700597,-0.053579826,0.03580473,0.013148977,0.00583853,0.0052130697,0.008438242,-0.01816259,0.05588276,-0.033129532,-0.04757237,-0.0947167,-0.0794811,-0.057734743,0.04845716,0.010862527,0.023379702,-0.027331246,-0.13610464,0.03967995,0.00084994093,0.014563996,0.047854807,-0.15236261,-0.06081229,-0.013673307,-0.07103654,-0.0017360188,0.0062942575,-0.022616906,-0.02060009,0.08953113,-0.045904808,0.047967065,0.05560739,0.035559457,-0.04632055,-0.0037844821,0.0077619003,-0.003317162,-0.015781837,-0.0026929816,-0.04313115,-0.007701626,0.020086676,-0.07278051,-0.02434752,-0.040166456,0.014204049,-0.015094746,0.0052525373,-0.033822436,0.023265813,-0.09166784,-0.009502828,0.016390452,0.013861484,-0.02337321,-0.02358285,-0.036445666,0.033347372,-0.03742059,0.012624219,-0.1095424,0.080579855,0.022135366,0.09255412,0.00852061,-0.000712652,0.05397471,0.07549139,0.0015694106,0.017215,0.06338664,-0.060350437,-0.00013909125,0.015934402,0.043683413,-0.022887362,0.09003686,-0.06893882,-0.05382929,0.016234983,-0.0075624106,-0.07987853,-0.031103035,0.03163563,0.02817985,0.101947315,0.0717499,-0.02051911,-0.051865816,-0.014475065,-0.021722434,0.053472087,0.027990896,-0.00028544912,0.00028773025,0.0744519,-0.0752855,-0.06662183,-0.077279,-0.041151788,0.008607674,0.066075295,-0.0006346302,-0.063783124,0.07134823,-0.010062532,3.9005845e-33,0.025259666,0.071629055,-0.08072725,-0.010740879,-0.022651922,0.04401477,0.032335084,0.08482639,-0.013717382,-0.12857102,-0.09593825,-0.05612161,-0.004687514,-0.005862293,-0.066615514,0.016169515,0.07575505,0.0065279277,0.06668324,-0.073422715,0.065619566,0.072538495,-0.09389272,0.016426805,0.042990066,-0.009419026,-0.03000875,0.025224034,0.01200377,-0.019673968,-0.0020806424,-0.02767795,-0.100410074,-0.043081477,0.0850796,-0.00041928867,-0.0033965777,0.007766511,-0.12124708,0.03100033,-0.020255165,0.002667123,0.031274952,-0.077109285,-0.018899785,-0.0045896666,-0.0026590868,0.07446195,-0.024450475,0.13754529,0.03295943,0.039344817,0.037320964,-0.0039246483,-0.05913383,0.0077788588,-0.015366688,-0.06463187,0.01803962,0.0035573507,-0.008326689,0.05079251,-0.0026928047,0.008743428,0.02929935,0.06879623,-0.022329926,-0.031259626,-0.005759701,0.08197917,-0.021647858,0.01817333,0.06278735,-0.025026727,0.054249685,-0.04301094,-0.13969153,0.028994696,0.03821364,-0.025784817,0.019638654,-0.1292206,-0.00686656,0.037583303,-0.045249987,-0.005184754,-0.012857591,-0.047976006,-0.04481077,-0.02339521,0.07429431,-0.06414011,-0.050481737,0.06601458,0.045048766,-4.064371e-33,0.08270652,-0.016123073,0.12645212,-0.010058722,-0.03995233,0.077188216,0.01790247,-0.043593124,-0.035735264,-0.015322436,0.10869382,-0.0067152116,0.048624076,-0.057173546,-0.029138405,-0.010222357,-0.008263743,0.03452265,-0.0055118366,-0.031824864,-0.059836097,0.078593455,-0.04233632,0.1002465,0.06168274,0.02196448,0.07543794,0.04724376,0.07720427,-0.017044783,0.01758706,0.09296168,0.009379963,-0.06651058,0.02204115,0.052445743,0.00010635491,0.016223738,0.016230186,-0.08385654,0.031838145,-0.049090497,-0.09345931,0.07749399,0.0060334294,0.08119477,-0.0035827407,-0.0022676173,-0.024010876,-0.11367092,0.06671843,0.022109026,0.028151326,-0.047528982,0.047908884,-0.0048937146,-0.07128844,-0.01685552,-0.07049732,-0.026871065,-0.031206645,0.022360798,0.0033537855,-0.026490627,0.021405058,-0.0196198,-0.0875605,0.09565375,0.0059535243,-0.026095511,0.005111426,-0.017323574,0.015691483,0.077766724,-0.019695615,-0.012801606,0.034321487,-0.016993968,0.07249898,0.008674318,0.008826999,-0.026561087,0.027682625,-0.07674457,-0.028836645,0.016177766,-0.011777878,0.013606556,-0.020067025,0.07608713,-0.0055119027,0.021782095,-0.0506108,0.050400335,0.029080741,-3.9173333e-08,0.051647987,0.058608435,0.06812415,-0.098184556,0.00780968,0.025861718,0.02615604,0.064432,0.0020060085,0.048749566,-0.08086207,-0.012031328,0.001322823,0.08809534,0.12061907,0.003270749,-0.04301856,-0.0050624963,0.0038153876,0.033572048,-0.05055635,-0.045092084,-0.12702666,0.0628545,0.02991668,-0.032028448,0.034077108,-0.031868253,-0.015095334,-0.055635646,0.004404556,0.0056967014,0.0035388926,0.07097197,0.00074857933,0.0646088,-0.002384071,-0.038402483,-0.051206734,0.01131634,-0.0197406,-0.041729413,-0.068106145,0.0023210843,-0.02408608,0.00228101,0.016009036,-0.06245713,-0.045198206,-0.066854484,0.024172882,0.043467008,0.011115008,-0.036893796,-0.029558884,0.033860672,-0.002771758,-0.07825919,-0.009679373,-0.050995972,0.12057347,-0.043996125,0.09395033,-0.012728749 +1.1.1.316,The enzyme catalyses a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway). The activity with NADP+ is less than 10% of the activity with NAD+. ,384,1.0,-0.08104414,-0.0016137428,-0.08683289,0.04002614,0.08198002,0.09712331,-0.10280291,0.05332181,0.02729517,0.045200903,0.039908554,0.04650002,-0.04556777,-0.04253223,-0.04048659,0.077091046,-0.027080331,0.040381234,-0.005747424,-0.053916603,0.07762454,-0.014026348,0.03878937,-0.05034771,0.13529722,-0.028278107,-0.12687725,-0.04921317,0.010227075,-0.06089438,-0.038941234,0.03992966,0.03921666,-0.06312506,0.020096747,0.048427206,-0.050373174,-0.023149312,0.051962927,-0.04683705,0.034047022,0.0004398194,-0.06331336,0.009489672,-0.066087015,-0.026334304,0.014772349,0.026668655,0.004939568,-0.031157868,-0.08189564,0.03249948,0.0018994234,-0.058094807,-0.047399774,-0.019833332,0.0061659478,-0.03317549,-0.018512191,-0.050361052,0.007863547,-0.070897765,-0.055522613,-0.022691095,0.02965746,-0.07080412,-0.04161279,-0.004474337,0.0044782916,-0.020959621,-0.07214882,-0.014799878,0.015209594,0.026146907,0.032116853,0.04983194,-0.08302314,0.028748345,0.019984858,-0.021488996,0.04613556,0.05823238,-0.026047999,0.029233353,0.05358468,0.040995095,-0.014148153,0.05011778,-0.009635499,0.06989051,-0.012927658,-0.024932178,-0.072612196,0.04091916,-0.1082481,0.03641724,0.06904475,-0.041846197,-0.0064225574,-0.03833399,0.031038206,0.07232547,-0.0026058755,-0.05297336,0.009215603,-0.0052841837,-0.103012055,0.011969415,-0.012008839,-0.023408264,-0.009800781,-0.01861377,-0.017251784,-0.037602767,0.020045653,0.098277025,-0.012381486,-0.04554928,-0.09259108,-0.06941202,0.021357212,-0.012329472,-0.009150283,0.070195265,-0.024598578,0.036560092,-0.08592285,7.426205e-34,0.062450822,0.059838407,-0.024423365,-0.024165945,0.028415795,-0.0017936523,-0.07674842,0.07420179,-0.02085598,-0.031362534,-0.06722129,-0.107305445,0.04632173,-0.011243324,-0.020573532,-0.06670675,-0.014331129,-0.09511309,0.048402686,-0.009126039,0.026984211,0.018637208,-0.078061946,0.10494236,-0.0031413534,-0.010658433,-0.02056941,0.05029061,-0.018711554,-0.018917838,0.08660741,-0.07161461,-0.1006341,-0.025611248,0.097406074,-0.009775846,-0.01061969,-0.059471656,-0.019323917,0.07196681,-0.085889675,0.09467356,-0.006476411,-0.034209754,-0.005523983,0.0073963455,-0.0011137859,0.060046103,0.10061794,0.07673396,0.009534882,0.0035412034,0.17250697,0.010682431,-0.0023305325,0.06351748,-0.03319867,-0.026917951,-0.01743884,0.06325386,0.017841686,-0.07203793,-0.02663452,0.022370009,-0.106444724,0.041656516,-0.078141086,-0.0012770173,0.10149556,0.091145106,-0.026958808,0.029157452,-0.017409168,0.01978779,0.06676512,0.0054734894,-0.015034246,0.071444474,-0.00703745,0.04221398,-0.026289625,0.009839215,-0.061791845,-0.024758812,-0.01785682,0.036624525,-0.024416735,-0.033414967,0.032649573,0.03557339,0.047848288,-0.03009765,0.013056852,0.006989688,0.07707379,-2.2538627e-33,0.086523764,-0.055105858,0.07234865,-0.020577826,-0.039814264,0.096506864,0.020993022,-0.07132412,-0.057842456,-0.015901916,-0.003947562,0.10694576,0.06461951,-0.002924759,0.07001278,-0.05188805,0.02120155,0.14135094,0.035155788,0.041413665,-0.050632693,0.12480078,0.013835,-0.010442045,0.07242623,-0.01602622,-0.06784916,0.047944803,0.02367296,0.023342546,0.06643978,0.024956567,-0.081051566,0.0032889976,-0.0068713487,0.025728328,-0.07389982,0.019522395,-0.027490718,0.05000705,0.060973592,0.008151619,-0.010610197,0.042244654,0.06652493,-0.023570282,-0.14587379,0.044838805,0.008801717,-0.042865783,0.0753339,0.06852721,-0.033493984,0.0071786856,0.09790394,0.04477713,0.033410512,0.015824925,0.018600773,-0.009182363,-0.035994127,-0.06707674,-0.01789492,-0.019582119,0.027455578,0.008374488,0.0397249,0.04355246,0.023354072,-0.0125296395,0.037355743,0.08960658,-0.0052177696,0.03442863,4.7323025e-05,-0.026324652,-0.071528085,0.011404238,-0.082405,0.015591986,-0.06620795,0.003367931,0.013205387,-0.09793476,-0.09942875,-0.004826114,0.0027695624,0.041703623,0.0071727564,0.029678209,-0.036424436,0.02707396,-0.020577623,0.033860616,0.02830611,-3.0130842e-08,-0.019387612,0.005910989,0.039080177,-0.0539366,-0.006631606,0.006078857,0.0002451171,-0.013960981,-0.0015761827,0.018304491,0.009089697,0.10637557,0.05004906,0.01223473,0.024579313,-0.070380725,0.009781841,0.01203858,-0.015068877,0.005320048,-0.07184945,0.021960646,-0.12720327,0.06330091,0.02264944,-0.056294765,0.0040729004,-0.036039043,0.083134234,-0.057696946,0.069831274,-0.0053747636,0.044255923,-0.03951361,-0.06877774,0.018021658,-6.585486e-05,-0.053761996,0.0505834,0.044183396,0.003963832,-0.11304772,-0.0031932523,0.037006788,-0.06507814,0.050884765,0.032187086,-0.05827493,-0.08521352,0.008653874,0.02411855,-0.008575927,0.0013889071,-0.0444867,-0.05756491,0.0010986963,0.02676675,-0.033171438,-0.04070918,-0.041721143,-0.021972654,-0.017124498,0.09286405,-0.04581592 +1.1.1.317,The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway. The enzyme is a member of the aldo-keto reductase enzyme superfamily from higher plants. ,384,0.99999994,-0.13864203,-0.017628368,-0.09674964,0.05933589,0.009989405,0.050202806,-0.103887744,0.024958253,0.008375462,-0.06014353,0.025426721,-0.007995235,-0.07678343,-0.0815538,-0.098053485,0.12224762,-0.08870843,0.116338044,-0.046224732,-0.048627768,0.057496697,0.017881569,-0.015322182,-0.009796059,0.07050003,-0.0056576203,0.007859781,-0.007630443,-0.025390932,-0.05432012,-0.016849885,-0.07695766,0.0354714,-0.031353902,0.037544522,0.0730071,-0.046551533,-0.06722099,0.037889965,0.0052804705,0.0011829771,-0.025761144,-0.052702367,0.01659369,0.0020445238,-0.02075104,0.017222034,-0.039851174,0.030705024,-0.050860416,-0.07648014,-0.044043016,-0.0434035,-0.06924368,-0.0059374617,0.009864373,-0.019731188,-0.0051486585,-0.011301586,0.039267056,0.08997453,-0.033033475,-0.07694185,-0.007369822,-0.045751717,-0.041630633,-0.015806798,0.011568136,0.11275892,-0.08757157,0.044341575,-0.073047586,-0.010300382,-0.036782425,-0.042760756,0.044923507,0.03159048,0.054636937,-0.012770461,-0.029584227,0.020890305,-0.013869508,0.044029925,-0.017978143,0.10145894,-0.0035239991,-0.0064250324,0.035170555,0.0052425107,0.06312053,0.0018078543,0.020856408,-0.01122926,-0.03224643,-0.0113637345,0.0700165,0.004992341,-0.05478372,-0.010750297,0.0069405804,-0.018207831,0.059933,0.03867755,0.03990221,0.020697225,0.011953923,-0.015594041,-0.000659624,-0.05807706,0.0042109285,-0.013885246,-0.015642228,-0.020161591,0.05886293,0.045533363,0.055521578,-0.015469626,-0.018543106,0.0442638,0.025947943,-0.05842375,-0.004282461,-0.044050768,0.0724321,0.038269952,0.011492037,-0.08962068,3.1971187e-33,0.058196604,0.07271749,-0.074922,-0.052796766,0.015144291,-0.018227857,-0.11386981,-0.0138744265,-0.011867263,0.005997493,-0.012249133,-0.08676796,0.005202815,-0.008895363,-0.046967622,-0.08259629,0.020838121,-0.043012835,0.021322688,-0.009096253,-0.056512315,0.06734797,-0.088383816,-0.00074086105,-0.037231624,-0.0032357702,0.0068688556,-0.0032515363,-0.06649574,0.015424137,0.021627896,-0.06507006,-0.014771103,0.012618089,-0.02552343,0.0038114272,-0.015063006,-0.07295984,-0.054089434,0.10201666,-0.03839568,0.045662206,-0.029359791,0.028835788,0.08088728,0.016366558,-0.031056968,0.13491653,0.0708769,0.08119194,-0.07574966,0.03693333,0.15092227,-0.02268963,-0.02197872,0.0028530408,-0.038254403,0.045005526,0.03183585,0.07260871,-0.004024137,0.03689726,-0.015788853,0.0424346,0.06460549,0.058011137,-0.10076806,-0.038815662,0.047404855,0.047753077,-0.04788254,-0.010859577,0.04810812,0.042574823,0.030640606,-0.01838303,-0.042827588,0.03486801,-0.019713933,-0.02112039,-0.01997117,0.052098326,0.027706167,-0.031308223,-0.01910223,0.04848496,-0.029932464,-0.082598336,0.08151434,0.039199132,0.05200853,0.013319149,-0.08814508,0.07049485,0.019097203,-2.9179359e-33,0.052658726,-0.034138743,0.03785318,-0.019497931,-0.060464796,0.10699802,-0.032634415,-0.002997448,0.042549558,0.059175905,0.01133611,0.012677434,0.047954574,-0.09002055,0.03192365,0.018811684,0.051019557,0.08495496,-0.013937856,0.019588333,-0.089438915,0.111170195,-0.005831269,0.02947364,0.010428254,-0.04928605,0.009997463,0.041381825,-0.04869808,0.0012846654,0.027727315,0.003880898,-0.012212498,-0.062503956,0.008310379,0.053192943,-0.07130094,0.13029215,0.014236659,0.08467498,0.050613713,0.011386999,-0.035132784,-0.008596448,0.017055953,0.017745439,-0.031542134,0.07274588,-0.035240334,-0.116389565,0.0041542505,-0.01035778,0.071784735,0.0066192057,0.052858297,0.032997962,0.04732185,0.004111812,0.031069292,0.0127271535,-0.009129962,-0.12073265,0.09636275,-0.02315449,0.039422084,0.018571598,-0.01222583,0.051414296,0.04470949,0.045339964,0.044269606,0.05605652,0.008926152,0.090574704,-0.033172376,0.020109927,-0.03198547,-0.086463675,-0.059765898,-0.047137633,0.0319289,0.009473345,0.020595849,-0.119626895,-0.038400475,-0.022697845,0.07017625,0.097312644,0.060219742,-0.04045991,0.015227172,0.015754217,-0.080236346,0.04662528,0.11144624,-2.9173234e-08,0.034080077,-0.02811025,0.055686887,0.03247361,0.047429603,0.046137135,0.051597565,0.03697314,-0.0005446139,0.061783474,-0.07210406,0.11210704,-0.020577507,-0.026968995,-0.030819623,0.065435976,0.030407388,-0.0038369077,0.018302761,0.06653402,-0.035539586,-0.010646796,-0.047979873,-0.0522393,-0.017934453,-0.09799034,0.035642587,0.06465402,0.019915387,-0.039448548,0.051353324,-0.0038758307,0.041922435,-0.061661,-0.08587984,0.0037976454,0.0036884146,-0.07862181,0.026688786,-0.05378278,-0.0028742864,-0.08304015,0.068817556,0.029972507,-0.04549685,0.0034581379,0.016210241,-0.016110238,-0.0125652505,-0.035811443,0.021550212,-0.05224576,0.023847139,-0.10947978,-0.039163288,-0.046157952,-0.010436432,-0.008016334,-0.046550352,-0.030458856,-0.0121659795,0.021766461,0.12266484,-0.092349514 +1.1.3.42,"The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone by some fungi. The bifunctional enzyme catalyses the oxidation of prosolanapyrone II and the subsequent Diels Alder cycloisomerization of the product prosolanapyrone III to (-)-solanapyrone A (cf. EC 5.5.1.20, prosolanapyrone III cycloisomerase). ",384,1.0,-0.074120186,-0.028396828,-0.110020466,0.019864138,0.10375891,-0.01354429,-0.06333298,0.05467427,0.010984161,-0.052501705,0.07159993,0.029472193,0.008645478,0.010075986,-0.04279531,0.0939471,-0.1351493,0.04626318,0.0010990443,0.008423317,0.028336396,0.020988248,-0.03190351,0.019942112,0.035428166,0.0038592415,0.027030854,0.015218708,-0.008646642,0.033163555,0.032408636,-0.03515004,-0.005799489,-0.03285354,0.015569372,0.047503136,-0.11199356,0.0015390285,0.11197152,0.042009957,0.026493328,0.040181756,-0.07883094,0.03189215,0.022004219,-0.06767292,-0.030951714,0.024675714,0.045015622,-0.029125907,-0.086952224,-0.037280988,-0.069986545,0.06605408,-0.03724795,-0.062348485,0.017798204,0.026096864,0.020885034,0.017356798,-0.0069549102,0.037293885,0.008142923,-0.043735012,-0.00385065,-0.04813449,-0.02531319,-0.042993817,-0.018125845,-0.04675941,-0.07560382,-0.04838568,-0.01857815,0.06842961,-0.003944891,-0.039906573,-0.041244105,-0.008108553,-0.10088001,0.037997928,0.051510017,-0.036387898,0.10652274,0.071361125,0.067965105,-0.0148425605,-0.013003046,0.027517226,0.05218582,0.007920499,0.058224533,-0.019309644,-0.003171919,0.030176494,-0.019419605,0.07310083,-0.0374384,0.08139859,-0.024067905,0.011118207,0.036220096,-0.0632945,-0.15823118,-0.07460538,0.021423722,0.02176676,0.056250736,0.03547553,-0.0034639614,0.00030272832,0.029866463,-0.048134316,-0.0013586076,-0.05490699,-0.044702817,0.10035268,-0.0022888693,0.03345815,0.0067079444,-0.026066165,0.026922707,0.052773517,0.060257766,-0.033359926,0.0061629172,0.040467758,-0.058530115,5.990095e-33,-0.012869154,0.029792322,-0.007461845,0.02111791,0.011159376,-0.06437331,-0.022053983,-0.013681384,0.026523897,-0.056430567,-0.14549625,-0.06242046,-0.04391452,-0.06980956,-0.014087548,-0.04749486,-0.0031989852,-0.040098123,0.054996364,0.04761255,0.068142876,-0.061398078,-0.028364193,0.033167616,0.0137452725,0.06915222,-0.011882911,0.04056962,0.056747854,-0.0202241,-0.009750642,-0.083934166,-0.11484829,0.033775292,0.031784307,-0.0072270655,-0.039986953,-0.06108277,-0.081361026,0.04687259,-0.098745525,0.02484408,-0.02222447,-0.022215627,0.076285675,0.037608292,-0.056953866,0.15601578,0.07982263,0.009494395,-0.030774724,-0.0052950447,0.061285418,0.06127135,-0.06266618,-0.0059750034,0.016303483,-0.039008882,0.055230964,0.049974896,-0.015407172,-0.019403642,-0.0019965512,0.027931307,-0.0044365665,0.060380682,-0.05037196,0.039276887,0.003395896,0.03180337,-0.08042829,0.0050487625,0.0070547415,0.07007428,0.0040091174,-0.03176868,-0.016249306,-0.006617157,-0.064546086,-0.015920928,-0.03419136,-0.090082735,-0.0010630735,0.030267898,-0.046392396,0.022924697,-0.08816348,-0.059935734,0.035724476,0.007002481,0.053289365,-0.019916253,-0.042534698,0.048887443,-0.03566296,-5.6110063e-33,0.08925748,-0.045606762,0.049604885,-0.07067418,-0.0086494,0.010531113,-0.096526004,-0.009629898,0.028459191,0.04439738,-0.053953942,-0.04434729,-0.010518604,0.01311342,-0.054233592,0.06516611,0.043919608,0.11634377,-0.028760096,-0.052425146,-0.028697163,0.07409233,-0.033188228,-0.041009653,0.03724482,0.029166875,0.05834817,0.04147713,0.053687386,0.051139627,-0.011971358,0.006328303,0.02110994,-0.012361951,-0.006681668,0.12309747,0.012442265,-0.028565753,0.016251044,0.0766793,0.027244901,0.026450159,0.016052,0.06568358,0.03250585,0.013245944,-0.06312083,-0.003249042,0.02634494,-0.09264195,0.05597249,0.050020304,-0.009850667,0.017356966,0.02646882,0.028436702,0.015753359,0.03566745,0.018831238,-0.0104952995,0.023781784,-0.048819035,-0.0034592873,0.012817144,0.041306775,0.009384297,-0.06565321,0.07530135,0.020544164,0.038377605,0.07252432,-0.04285152,-0.024193462,0.08939337,-0.08872905,0.023176895,0.004415724,-0.007654702,0.0015754532,0.03316649,0.07284393,-0.09013463,0.069685586,-0.03717928,-0.08674104,-0.084185414,0.054298967,0.049400825,-0.052164335,-0.014275254,-0.013134789,0.0014520434,0.020400997,0.09988828,0.056507364,-4.04793e-08,0.01783958,-0.014944168,-0.0021118994,-0.06560214,-0.0134930555,0.030484257,0.011032331,0.020896908,-0.001932799,0.009026232,-0.068330824,0.05181179,0.050013363,-0.024688466,0.05379004,0.03618558,-0.010641166,0.08910784,0.0019136938,0.03301598,0.0060197515,-0.054393217,-0.090109736,-0.03547024,-0.002046963,-0.10429078,0.0229731,0.05547637,-0.008134152,-0.01030672,-0.0729755,0.0018245453,0.056929033,-0.07717133,-0.06744191,0.084184475,-0.08078757,-0.080306076,0.047419008,-0.014229463,-0.037532594,-0.09488301,-0.11092504,0.014257563,0.03248393,-0.024224907,0.027850661,-0.009631277,0.0014385104,-0.054341037,0.06604256,-0.03222395,0.039550897,-0.011239883,-0.029148368,0.05243088,-0.021601189,0.049735855,-0.033162333,-0.118423715,-0.037494794,0.08582696,0.18778878,-0.013969885 +1.1.9.1,"A soluble, periplasmic PQQ-containing quinohemoprotein. Also contains a single heme c. Occurs in Comamonas and Pseudomonas. Does not require an amine activator. Oxidizes a wide range of primary and secondary alcohols, and also aldehydes and large substrates such as sterols; methanol is not a substrate. Usually assayed with phenazine methosulfate or ferricyanide. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed β€˜propeller’ structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ.",384,0.99999994,-0.058770582,-0.01222419,-0.039757628,-0.049811576,0.009154601,0.0050128456,-0.02053209,0.08430638,0.043943476,0.0342211,0.044374846,-0.030640587,-0.07242596,0.0944993,-0.05720385,0.06799734,-0.06071078,-0.037109464,0.035749238,0.01802331,0.0140507575,0.06867907,-0.04258386,-0.007256194,0.0016588742,0.04785838,0.047288235,0.098775685,0.0024957324,-0.032588314,-0.013817165,0.04881528,0.09019748,0.0018223027,0.07397758,0.09242243,-0.046866123,-0.030772246,0.024084687,-0.036755607,0.08606991,0.035911083,0.0063926154,0.00905773,0.072121225,-0.011246522,-0.032459047,0.09892034,-0.026334483,-0.014908035,-0.068029486,-0.07380626,0.03317928,0.10089823,0.06585854,0.06070645,-0.033733316,0.017117906,-0.026504813,0.053606145,0.0099077355,0.06126562,-0.007561451,-0.028419234,0.018821862,-0.059889805,0.078177035,-0.009571945,0.071648434,-0.050531995,-0.03998534,-0.035177857,-0.010270432,-0.029198421,-0.047317393,0.032298926,-0.01671666,-0.06508265,-0.012886968,-0.04806071,0.009533603,-0.0004939649,0.028776832,0.07840024,0.11272861,0.00728447,-0.057289764,-0.044595197,-0.017574819,-0.061278436,-0.019105846,-0.012344029,-0.02216776,-0.09273187,-0.020606956,0.09783501,0.037519965,-0.025667792,0.010594758,-0.005573545,0.051689643,0.027547663,-0.036000814,-0.039433457,-0.07497156,0.025121061,0.026833734,0.070072256,-0.010527705,-0.0021568448,0.0033793969,0.0141238915,0.08722752,-0.044231243,0.054475456,0.02786273,0.052313384,-0.012187006,-0.011791981,-0.06299077,-0.024047337,-0.0280494,0.0398174,-0.025691314,0.01920778,-0.0035376397,-0.07523428,3.7785414e-33,0.098805286,0.030845867,0.008896555,0.03451529,-0.009499617,-0.031441897,-0.012485711,0.041459877,-0.04491532,-0.035601355,-0.01362916,-0.04422286,0.02962715,-0.008123979,-0.021714503,0.0014133049,-0.051209345,-0.013079722,0.066913575,-0.012839573,0.00897568,-0.009629763,-0.12377687,-0.0020969238,0.0570062,0.04831182,0.0032081888,-0.01295268,0.025878169,-0.0027755974,-0.0104974955,-0.0032120626,-0.098192066,-0.0126627395,-0.008694253,0.038832054,-0.1219438,0.016854132,-0.12894763,0.03509295,-0.00965203,0.034379624,0.017513577,-0.057978198,0.029997671,-0.052713815,-0.055882983,0.063077115,0.032420713,0.01951804,0.03533992,-0.02949604,0.0791135,-0.03667791,-0.08043257,0.0021642616,0.028955985,-0.028263677,0.06763199,0.037294555,0.049900614,0.023590079,-0.1583483,0.024662115,-0.0017938773,0.018494455,-0.097213976,-0.088691905,0.04380397,0.12998356,-0.010948432,-0.0059300032,0.04716127,0.00046377073,-0.035824765,-0.03876977,-0.05736291,0.053030297,0.053461183,0.017576532,0.06541177,-0.06513067,0.0482664,0.008587969,-0.037597325,-0.07457447,0.07604951,-0.046346646,-0.040815435,-0.026165117,0.032321785,-0.08846679,-0.03157189,0.005688866,0.02611326,-3.6230973e-33,0.09350731,-0.048701447,0.008932072,-0.026635105,-0.016246954,0.053610414,-0.009296939,-0.023326803,0.016774394,-0.13504197,0.053991564,-0.006616168,-0.0029718261,-0.010080757,0.043394726,0.06726143,-0.026976071,0.04809944,0.013618211,0.01744195,0.007189282,0.0396526,0.049153425,0.020684619,0.08438923,0.0043935804,0.026809826,-0.027557557,0.014318428,0.085336745,-0.076720946,-0.045892388,-0.05892224,-0.06592035,-0.07154233,0.024137633,-0.10342852,0.012660197,-0.0020682288,0.013295081,-0.0014993766,0.0038516694,0.027660744,0.093206696,0.001632202,0.07243642,-0.07078109,-0.024937231,-0.0056735193,-0.02058791,0.052266825,0.018921899,-0.053065088,0.05505524,0.038028132,0.06926682,-0.028853185,0.025484249,0.011683017,-0.042082008,-0.078562304,-0.05637193,-0.058331653,-0.04466808,0.013251417,0.06378599,-0.0121611785,0.12784225,0.016694933,-0.09801627,0.020276919,0.0060734157,0.050308775,-0.003081329,-0.10366201,-0.028672699,-0.08349984,-0.0005073015,0.023479275,0.06417045,0.06264947,-0.04274467,-0.024019672,-0.009195151,-0.028536532,-0.091487564,0.04610715,0.068690866,-0.034998026,0.019210264,0.013769437,0.035247542,-0.0016375188,0.036477923,0.05056236,-4.3861885e-08,0.005235191,-0.043685835,-0.0013177646,-0.026635477,0.010264556,0.0131717,0.045360554,0.028342536,0.051576603,0.05814263,0.027936008,0.041993447,-0.052706737,0.014342431,0.034985077,0.043989327,-0.09474289,-0.01538836,-0.075928524,-0.014704586,-0.07849281,0.0234577,-0.09215915,0.0012000682,-0.04168367,-0.0027483925,0.0065322043,-0.06832563,0.003967369,0.006980765,-0.043342214,0.059443895,0.028139735,-0.033412226,-0.07546834,0.019725857,-0.0109920055,-0.028449485,-0.065610714,-0.018077102,0.021026043,-0.10628372,-0.0915463,0.028150754,0.055794254,-0.013103838,-0.021887718,0.026640797,-0.045601796,-0.011548101,0.08023304,-0.0053424654,0.05285482,-0.03612064,-0.14514713,0.028591197,0.036766823,-0.046533346,-0.033679754,-0.08858046,0.08280956,-0.0029324498,0.2092335,0.08024103 +1.10.9.1,"Contains two b-type cytochromes, two c-type cytochromes (cn and f), and a [2Fe-2S] Rieske cluster. The enzyme plays a key role in photosynthesis, transferring electrons from photosystem II (EC 1.10.3.9) to photosystem I (EC 1.97.1.12). Cytochrome c-552 can act as acceptor instead of plastocyanin, but more slowly. In chloroplasts, protons are translocated through the thylakoid membrane from the stroma to the lumen. The mechanism occurs through the Q cycle as in EC 1.10.2.2, quinol---cytochrome-c reductase (complex III) and involves electron bifurcation.",384,0.99999994,-0.13348436,0.015011694,-0.10708751,0.0047630123,0.06539548,-0.015468276,-0.021115381,0.06635414,0.045310155,-0.018518912,0.048941478,-0.01974324,0.025642294,-0.004078387,0.024203539,0.07172973,-0.14333124,0.007343463,-0.010977552,-0.04685387,-0.009949887,-0.11982613,-0.026776299,-0.055999435,-0.004752038,0.022876054,-0.034589257,-0.008972339,-0.06510513,-0.07709351,-0.04215153,-0.013370682,-0.0219195,0.049607567,0.02257046,0.12500657,-0.057129234,-0.1253147,-0.017750932,-0.032070193,0.0040484047,0.03414412,-0.03975407,0.017035263,0.0038019908,-0.025819069,0.0035319994,0.020079307,-0.037176177,-0.09732123,0.02698175,-0.0072182114,-0.038144894,0.07285618,0.008249645,0.06553535,-0.031281035,0.020854272,0.024058752,0.0139714815,0.011673387,-0.00976518,0.023643686,0.02686443,0.016107017,-0.06761575,-0.0011132918,-0.05499964,0.04591764,-0.11472255,-0.05277875,-0.021469796,-0.016542027,-0.048119236,0.041576937,-0.008248106,0.015381794,0.04044835,-0.033951662,-0.032518726,-0.017542424,-0.012386396,0.002912881,0.057524066,0.06361603,-0.026340576,-0.007889817,-0.019055337,-0.07084954,0.030124713,0.02843066,0.016978325,-0.0009593925,-0.022105481,-0.06535179,0.082404464,0.06659883,0.001740678,0.056870088,-0.035444465,0.06210307,0.08781269,-0.008198058,-0.07914719,0.021105276,-0.05051995,-0.02730879,0.11114534,-0.05497243,-0.04100768,0.004277626,0.020961147,0.023739614,-0.00997156,-0.008296101,0.071132295,0.059162706,0.039594997,-0.0020743345,0.030026663,-0.04042673,0.0036617701,-0.08032093,-0.022657048,-0.031619985,-0.027017193,-0.13313524,2.4128428e-33,0.039725702,-0.0189273,0.03485612,0.001073472,-0.056466196,0.0029852313,-0.08355825,-0.02506588,-0.07227659,-0.08414965,-0.0545485,-0.087418124,0.034973327,-0.052932564,-0.020814165,-0.041198168,-0.034669943,-0.014066968,0.0066162134,0.015003186,0.041356467,0.032822736,-0.05103546,-0.043000814,0.06595955,0.06260404,0.020249974,-0.010531739,0.035962593,-0.0072220024,0.013809329,-0.016301457,-0.07559954,0.054864064,0.077713884,0.0048860684,-0.021518981,0.020478945,-0.009417822,0.0112223895,-0.07919553,-0.004806012,-0.0379225,-0.012371211,0.061425056,-0.007655388,-0.028995732,0.048598148,0.06796091,0.031564966,-0.0035762766,-0.09329831,0.060090564,0.01695012,-0.015456575,0.004892169,0.08729337,-0.055605058,-0.023043126,0.058347702,0.10307053,0.07364815,-0.046282556,0.03164666,0.04545912,0.08832323,-0.10220959,-0.002850507,-0.035377458,0.1042713,-0.05632395,-0.0349177,0.053349532,-0.0013865642,0.110900104,0.008835183,-0.05349219,-0.009160042,0.014595647,0.083608605,0.029220456,-0.033635587,0.047908902,-0.04552184,-0.051297322,-0.080981225,0.0024927226,-0.0748817,-0.0005526546,0.08219487,0.075009435,-0.025961604,0.032581035,-0.024258122,-0.004601604,-3.7654967e-33,0.08289413,-0.029281337,0.03919368,-0.07089051,-0.00624533,0.056174237,-0.077491656,-0.045675855,0.018823655,0.039512727,0.07042746,0.011287079,-0.06773195,0.03584723,-0.018064098,-0.034554143,0.011838211,0.056953408,-0.0139029445,0.05372535,-0.040243164,0.02626623,0.07578368,-0.0027670902,0.06313582,0.0051188245,0.00023244786,-0.0036975802,0.07170449,0.0007588888,-0.09409731,-0.047248032,-0.03117564,0.022233944,0.016052334,0.0005449193,-0.08658187,-0.009783215,0.025121607,0.04714315,-0.03931083,-0.059778426,0.032992303,0.0197025,0.01585788,0.036227282,-0.080024146,0.042025074,-0.05336028,-0.0047111013,-0.0012218283,0.044612087,-0.035405844,0.085187465,0.0377217,0.060524292,0.004200345,0.03205439,0.034723505,-0.049269516,-0.026802436,-0.13534282,-0.04250393,-0.0073768403,0.021848228,-0.036610674,0.013999143,0.03990333,0.008872864,-0.012560368,0.056917883,0.02695155,0.07011627,0.00863414,-0.0418369,-0.038295563,-0.013198322,-0.02282132,0.02226481,-0.052686825,0.020816829,0.016232599,0.007832668,-0.041254524,-0.009245072,-0.08527598,0.0014144098,-0.0007840414,-0.02770903,-0.06386894,0.041812737,0.043011125,0.03386162,0.07993483,0.07620769,-4.5165603e-08,-0.017990852,-0.034603387,0.018470723,-0.026947767,0.08358642,-0.028802417,-0.019988213,0.0068450333,0.04390908,0.022469752,-0.0064705852,0.1193415,0.099874154,-0.12413176,0.04713805,0.10084434,0.056071352,-0.03854291,0.068359606,0.08330707,-0.07941669,-0.11948981,-0.17592424,0.043947093,0.009715731,-0.018895632,0.058684915,0.048215233,-0.014635868,-0.012866183,0.07503955,-0.014175413,0.041288543,0.036819287,-0.044390935,-0.013518042,-0.058357164,-0.07110561,-0.035521116,-0.013562217,0.053339902,-0.0012441606,-0.03437976,0.06953392,-0.011207729,0.004608061,0.03630095,0.05084109,-0.029731192,0.049895845,0.009406747,-0.02707714,0.03583688,-0.10647314,-0.07992408,0.022747282,0.076690115,-0.009500624,-0.009316141,0.040550523,0.05323446,0.031136338,0.13467693,0.050200194 +1.13.11.60,"The enzyme contains heme [1,4]. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is subsequently isomerized by the C-terminal P-450 heme thiolate domain to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.5, 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase) [1]. The bifunctional enzyme from Gaeumannomyces graminis also catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase) [4].",384,1.0,-0.03787443,-0.03685786,-0.11168757,-0.05559129,0.10082131,-0.02140266,-0.08592034,0.0629083,0.046217732,-0.058668714,-0.0036701977,-0.017445572,-0.06225758,0.05822192,-0.057693418,0.016881265,-0.0043558776,0.03950216,-0.05518556,-0.015501354,0.104857996,0.038850162,-0.013261387,0.021291802,0.039104298,-0.031107696,0.114347175,-0.055347927,-0.041627735,-0.1340498,-0.0025375844,-0.049509455,0.048354216,-0.0283521,0.022294594,0.040120978,-0.043025192,-0.075326115,0.032912478,0.0013319704,0.017771749,-0.057327673,-0.025999218,-0.07655536,-0.08852917,0.01842355,0.018194275,-0.017855966,0.004696732,0.045654923,0.0017293876,-0.055588305,-0.04789031,0.0132550765,-0.00498687,-0.008590426,-0.018548828,-0.03743309,-0.014180575,0.01864683,0.028151257,-0.008426441,0.0063483994,0.023844434,-0.069985114,-0.061720233,0.061211918,-0.0651131,-0.09376751,-0.10842345,-0.006367679,-0.043396216,-0.012108446,-0.0012610878,-0.008643261,0.08761025,0.014664551,-0.023847297,0.046148483,-0.03177344,0.055013116,0.061439853,0.019794334,0.10089755,0.034901112,0.03497705,-0.04603462,0.03911044,0.026622677,0.0024187113,0.062108513,0.054539904,-0.014477907,-0.03211128,-0.02728628,0.05464035,0.059796583,0.12887058,0.001925459,-0.02388909,0.020749154,0.04713877,0.008676773,-0.075340375,-0.02877297,0.03126114,0.006654872,0.08621978,0.124787994,-0.013444594,-0.030460855,-0.02432019,0.07702296,-0.0075069563,-0.0019278894,-0.007478158,0.02257631,-0.03776424,0.0020954544,-0.020858372,-0.014022966,-0.011661235,-0.0060033575,-0.010741136,-0.0020402838,0.056308173,-0.013421749,6.6747104e-33,0.043946847,0.03680669,-0.05274558,-0.022535345,0.01975975,0.013237781,-0.06454595,0.011163478,-0.047910847,0.013883169,-0.09274305,0.027789073,-0.0054889554,-0.050052833,-0.015119358,0.040327407,0.024421584,0.0034650925,0.063502714,0.031696294,0.031496894,0.04013481,-0.085714705,0.04160927,-0.009998922,0.062255774,0.024168734,-0.015304095,0.010758301,-0.035096396,-0.023855997,-0.04209207,-0.07690028,-0.0036040328,0.072067775,-0.04986004,0.04043641,0.06343296,-0.085664175,-0.02183832,0.002617777,0.05003557,-0.033192776,-0.0611445,0.05179388,-0.08770161,-0.039453838,0.121135406,0.108208805,0.07385526,0.051069185,0.008153434,0.10796075,0.02814751,-0.0034930704,0.029172596,-0.019851593,-0.005890765,0.0757251,0.02210877,0.03235492,0.07429047,-0.005193094,0.0005931446,0.0802617,0.02915863,-0.08113108,-0.05578383,0.070342526,0.005556621,-0.032121316,0.0466757,0.028739922,0.03040493,0.010530743,-0.07443179,-0.0515417,-0.011256814,0.08120188,-0.0068533015,0.053053502,0.053468052,0.043234684,-0.03607224,-0.06732018,0.021486588,0.0028668952,0.016173126,-0.114003785,0.012893558,0.030328738,-0.09224699,-0.031206613,0.009101907,0.058608294,-6.307432e-33,0.16862044,-0.118245706,-0.021695497,-0.089822374,-0.015686583,0.033739768,0.016913109,-0.033864867,-0.027961772,-0.036795925,0.10632049,0.01541449,0.051166557,0.054669812,0.0770196,-0.008041716,-0.00046847636,0.09787732,-0.035475764,-0.038431328,0.0044543324,0.072198085,-0.06452664,0.07216901,0.04077054,0.014713305,-0.01624992,0.010906227,0.043888494,0.09783849,0.011594265,0.030880243,-0.041381728,-0.024908826,0.0038537772,0.024017468,-0.0006868382,0.07459004,0.004630642,-0.022587845,-0.026261497,-0.001348927,0.0017792068,0.01585624,0.022026718,0.086169444,-0.12879036,0.014235558,0.009981264,-0.025898306,-0.001346805,0.029903483,-0.08034644,0.011353151,0.04174952,0.010489125,-0.017332084,-0.014562289,-0.023429558,-0.13381211,-0.058012642,0.0077177593,0.0016211483,-0.0095766,-0.0069995215,0.10801839,-0.120746955,0.0041034725,0.013246089,-0.02622651,-0.038098775,-0.0025931974,-0.012407734,-0.0127909575,0.009605606,-0.048766308,0.04594104,-0.023464188,0.009803586,-0.011483425,0.0049365787,-0.045945995,0.0017066645,-0.095076695,-0.03458692,-0.04933586,0.062373843,0.08887066,-0.0015728732,-0.018576559,0.010806681,0.01174274,-0.067790106,0.009332124,0.04377159,-5.4425072e-08,-0.033092238,-0.027592268,0.015990669,-0.06745273,-0.023760218,-0.0025102918,0.02743848,-0.03305716,0.09566375,-0.027856715,0.023604484,0.112412386,-0.06375023,0.037802324,0.06147501,-0.00061562477,-0.019915693,0.027108906,0.027294261,0.028565561,-0.03699715,-0.027984448,-0.048550338,-0.055524025,0.014605344,-0.109850995,0.0111114625,-0.058836076,0.06009436,0.0645634,-0.036130674,0.075555235,0.0011109241,-0.085260265,0.037061054,-0.008198803,0.053020652,0.0030947202,-0.023308333,-0.0029955658,0.025687551,-0.06716625,-0.111535765,-0.02915553,0.009415983,-0.042664226,0.05441121,0.017833047,0.0070629027,0.009296093,-0.0018444321,-0.027329514,-0.028434942,-0.031482566,-0.06230137,-0.05215254,0.030841481,-0.06463435,-0.08057235,-0.027422817,0.00058147777,-0.010480235,0.20762353,-0.03837269 +1.13.11.61,"In cyanobacteria the enzyme is involved in oxylipin biosynthesis. The enzyme also converts linoleate to (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate. 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+1.13.11.62,"The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp. 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+1.14.13.133,A heme-thiolate protein (P-450). The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics.,384,1.0,-0.031201633,0.020030094,-0.049910747,-0.04589663,0.005049772,0.0017161082,-0.022690075,0.1102992,0.064713,-0.023642028,0.001247028,0.016574182,-0.082704134,0.084091276,-0.041739367,-0.0064170007,-0.075181305,-0.0035280176,0.0019164232,-0.067787826,0.054257818,0.0798182,-0.0021152569,-0.017179817,-0.0034837525,0.037928123,0.053001575,0.07724898,-0.0015824776,-0.08261317,-0.023801299,-0.03055874,0.05027395,-0.08538586,0.045012515,0.09605077,-0.10152719,-0.051087093,0.07490852,0.00588514,0.113315925,-0.07237066,-0.011455302,0.021696722,-0.02930763,0.024141416,-0.01524935,0.11177269,-0.017073039,0.033629995,-0.025425956,-0.05151245,-0.03905228,0.04441331,-0.0037580188,-0.023853812,0.04631527,-0.018400336,-0.00029309685,-0.090731174,0.016518546,0.09643435,-0.022627657,0.024779374,-0.044694386,-0.04578541,0.05537294,-0.023971952,0.016567385,-0.035068825,-0.0141824735,-0.0041752816,0.0057359184,0.043931413,-0.008298868,0.0077849706,-0.056785908,-0.035265274,-0.0593808,-0.016462848,0.08123098,0.09509704,-0.040082917,0.11936756,0.06031989,-0.021466235,0.012408324,0.026498383,-0.016115965,-0.038888626,0.018604182,-0.0018046581,-0.03587019,-0.015937883,-0.1287562,0.041395757,-0.014120992,-0.008769638,-0.035900876,-0.016973596,0.008549059,0.023139922,-0.038506135,-0.08185451,-0.046996526,0.021284185,-0.030940847,0.01648258,0.066960685,-0.03604578,-0.03936946,-0.03306763,0.02786424,-0.051219102,-0.0038723056,0.05906833,-0.043766502,-0.016246261,0.006653428,0.023599185,-0.019711155,-0.027004091,-0.024944268,0.05158134,-0.04164857,0.022101734,-0.07316209,-8.982103e-34,0.061037797,0.025263205,-0.0017463852,0.011268893,0.0417062,-0.040925875,-0.04677481,-0.015422637,-0.06871718,-0.021642877,-0.082559094,-0.1502874,0.009215917,-0.0041478705,-0.049259588,-0.022068443,-0.036891878,0.080039956,0.011788845,0.05799352,0.020151922,0.07164853,-0.06983255,0.03622894,0.030309029,0.0832356,0.0013793566,0.027942786,0.09112678,-0.015268661,-0.02033555,-0.0028775416,-0.029463122,-0.089480944,0.018708125,-0.057195388,-0.0020179374,-0.071159676,-0.042505294,0.06469745,0.006013537,-0.01112409,-0.026153373,-0.020312857,0.10470923,-0.029740779,-0.0987537,0.044696398,0.017577508,0.015477827,0.08503722,-0.057430346,0.114359535,0.032779064,-0.059511278,-0.024584275,-0.05910255,0.043856256,0.037992228,0.030506032,0.12367253,0.056454007,-0.025772275,-0.023122756,-0.028684525,0.04246017,-0.013065855,-0.040921208,0.008548977,0.06389295,-0.073227435,-0.050293606,0.020501405,0.0036500483,0.05192721,-0.011265739,-0.037559994,0.040705845,0.049278468,-0.0017754603,-0.03430504,-0.03546481,-0.0081455475,-0.038271125,-0.032207593,-0.05376895,0.034433983,-0.015210918,-0.010438839,-0.0061748927,0.044450726,-0.09188094,-0.057923384,0.045175664,-0.00924337,1.4607442e-34,0.062428594,-0.0938274,0.06624167,-0.03720128,-0.0832427,0.07147375,-0.021334892,-0.008051873,-0.014354876,0.013649068,0.10144084,-0.058209024,-0.015147221,-0.03417848,0.000241147,0.020461434,-0.0059797135,0.03220153,-0.026473068,0.05386585,-0.04659487,0.001790027,0.015246917,0.031645194,0.04787708,0.06142896,-0.0036584125,0.010831454,0.03556621,0.032233525,-0.039067354,0.0026210356,-0.07903225,-0.0315376,-0.10251983,0.102553844,0.030122966,-0.007418137,-0.0027237008,0.036584638,-0.008255855,0.015359679,0.05595268,0.087387286,0.011131131,0.068613105,-0.072835416,-0.020681186,0.02196893,-0.049872283,0.06278535,0.044045534,0.038826298,0.044099938,-0.015982753,-0.015809936,-0.039374486,0.022531016,0.021887695,-0.07274191,-0.039772376,-0.046857707,0.028097233,0.07901366,0.04737346,0.05081156,-0.060732853,0.07572505,0.06399148,-0.0117926905,-0.014957547,0.102326915,0.07328185,0.026439205,0.00887304,0.013763031,-0.028406993,-0.1026698,0.041086063,-0.002944636,-0.058028203,-0.035081305,-0.060223866,-0.044329803,-0.06824496,-0.041312564,0.057399724,0.11599724,0.04540259,0.021761065,-0.016761152,0.039593186,-0.03812673,0.06844147,0.07587057,-2.8180235e-08,0.03040226,-0.08234452,-0.008277766,-0.019976586,0.01790137,-0.005055799,0.012327749,-0.0061903917,0.053411763,0.034625452,-0.015318719,0.029781854,-0.02670656,-0.03655073,0.047589187,0.052928537,0.00392743,0.007158256,0.018479759,0.012271773,-0.024627544,0.03422408,-0.057169292,0.017331297,0.07701384,-0.07621523,0.046429753,-0.023585591,-0.014928253,-0.012408191,0.0071806405,0.03150712,-0.05825742,0.011534914,0.031032344,0.09743284,-0.100097045,-0.025672588,-0.0197954,-0.031510323,0.038033657,-0.06499498,-0.08905653,-0.0466168,0.01578053,0.022058912,0.012368069,0.026227402,-0.07145885,-0.06951995,0.001094796,0.012742417,-0.008534141,-0.029719366,-0.1346024,0.019814944,0.03971911,-0.041637156,-0.04887462,-0.106654905,-0.019179782,-0.033600807,0.26655066,0.0016775213 +1.14.13.134,"Requires cytochrome P-450. Part of the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-beta-amyrin to 11alpha,30-dihydroxy-beta-amyrin but this is not thought to be part of glycyrrhizin biosynthesis.",384,1.0,-0.090502664,-0.021820076,-0.07279562,-0.0026131356,0.03996489,0.00086639635,-0.06576077,-0.027277498,0.0031835258,-0.037881635,-0.020240476,0.07154205,-0.046048928,0.029364837,-0.052732874,0.0006801046,-0.08568108,0.0120633,-0.07554579,-0.0006472231,0.022519402,0.028476376,0.06659702,0.019157603,0.016163005,-0.028343137,0.0007955273,0.1060269,0.051162895,-0.008951121,0.030690633,0.008090842,-0.04402926,0.012061662,-0.024373537,0.10588959,-0.09845811,-0.032786325,0.055478636,-0.021889415,0.06031513,-0.048482757,-0.0660194,-0.008933572,0.037552837,-0.0783622,-0.06224851,-0.021146337,-0.0121660195,-0.04877876,-0.027958049,-0.03694649,-0.03677855,0.02006255,0.061624467,0.03400291,-0.00013330604,-0.056390498,0.030226935,-0.005288349,-0.03019283,0.042154226,-0.040099602,0.022848742,-0.077177376,-0.049111918,-0.010887468,-0.051180307,-0.008789886,-0.014363553,-0.04061424,-0.09467108,-0.023857947,-0.041147385,-0.10700597,0.048984915,-0.002561154,-0.018656813,-0.015368761,-0.013888279,0.024088454,-0.058211964,0.08758461,0.12887457,0.051471077,-0.026552627,0.0035479285,0.02528761,-0.035414197,0.031120623,0.032876782,-0.026433077,0.051364932,-0.020350732,-0.016619237,0.018896429,0.04264739,-0.06544845,-0.00744238,-0.01196619,-0.03098513,0.047772978,0.03516512,-0.09402978,-0.031573556,0.034380693,0.04908126,0.0765231,0.035290882,-0.056028504,-0.06002755,-0.011220505,-0.01285783,-0.042573243,0.020596964,0.041717283,-0.025234625,-0.018083785,0.015026333,0.0016491144,-0.03726738,-0.01438445,0.0077372477,0.016504161,-0.043474384,0.023481006,-0.07851421,3.6955853e-33,0.1398428,0.06356769,-0.007518515,-0.019420883,0.03267925,0.059243582,-0.061440144,-0.03867209,0.005745367,-0.06570206,-0.0292691,-0.084672436,-0.05306559,0.018409966,-0.0055739153,0.061660964,-0.07712196,-0.03598384,0.06997269,0.014659067,0.007321145,-0.06345112,-0.07133594,-0.058638338,0.033792946,0.055458847,-0.02725276,0.06816947,0.036692217,0.020108936,0.0058072964,-0.031752396,-0.11527636,0.0026005919,0.04823312,0.017365662,-0.007616311,0.013323761,0.016433354,0.054599587,0.03161553,-0.058089625,-0.025937395,-0.03422788,0.078438595,0.071506545,-0.037574396,0.09053168,0.000771185,0.11563345,0.069428526,-0.027250374,0.058650106,0.018393131,-0.09982187,0.005110643,0.015505458,-0.053830765,0.051624216,0.07581368,0.041573305,-0.0014272725,0.049565613,0.04520353,0.07066979,0.070136875,-0.025263097,0.0066860053,-0.10306494,0.042838797,-0.029815326,-0.06953327,0.09983993,-0.0024939766,0.028996605,-0.018665735,-0.011845289,0.0040609096,0.03964671,0.0028811756,-0.02356027,0.004995989,-0.017388605,-0.035103448,0.015109268,0.031815093,-0.017386287,-0.052364126,-0.024744743,0.023692852,0.10061719,-0.10016729,0.05300897,-0.0010985999,-0.028415339,-4.9491986e-33,0.09335874,-0.066922784,0.031164262,-0.08812185,-0.014380719,0.0014087519,0.055159576,-0.09826428,0.058865536,0.05561161,0.04154168,-0.036801267,-0.017954849,-0.024720354,-0.034750942,-0.013396828,-0.0053608916,0.1306054,0.031443026,-0.00687028,0.05043065,0.014679245,-0.0017186623,-0.0012545416,0.041131828,0.08654146,0.011154894,0.005018807,-0.0030869846,0.034942903,-0.07713151,0.04358896,-0.07898751,-0.066208415,-0.060045924,0.07335562,-0.09514193,0.002445118,-0.021091226,-0.039981596,0.008875841,0.025813607,0.006154137,0.12184928,0.06492266,0.022819316,-0.017637676,-0.031006087,-0.0025278828,-0.028726872,0.03951251,0.03929964,0.0021858118,0.09483979,-0.009723893,0.052219067,0.042641807,0.017533738,0.0015652541,-0.044156063,-0.040046416,0.012732374,-0.0025829575,0.021197654,0.026297262,0.050664075,0.053695455,0.09304021,0.052872777,0.0035817523,-0.0001303973,-0.013282114,0.11602783,0.10528019,-0.014157195,0.08962913,-0.022606362,-0.023753826,0.04466894,-0.025637612,0.037217274,0.008830165,-0.09083774,-0.03549722,-0.08674622,-0.13943708,0.0032450685,0.092509076,0.030520294,-0.051208112,0.014958292,0.08054294,0.0036225498,0.04348087,0.053940807,-3.533839e-08,0.03450948,-0.06760966,0.03841895,-0.057083204,0.074562825,0.016188959,0.014497648,0.012747495,0.046914913,-0.022011291,-0.016402103,0.07813577,-0.010586591,-0.017738497,-0.03987932,-0.003413105,-0.021034332,0.030631928,0.005103063,-0.045015737,-0.13851333,0.010678477,-0.04762245,0.0514439,0.030296683,-0.1285983,-0.013940593,0.040020525,-0.020600485,0.0050147767,0.017778724,0.038707882,-0.09336806,-0.042515468,-0.009238984,0.030925382,-0.027085738,-0.063675836,-0.013497602,-0.08478301,-0.067504905,-0.08658037,0.005586476,-0.017397031,-0.0039075543,-0.007875081,-0.042498153,-0.018642394,-0.011545477,0.044530887,0.018202776,-4.9414288e-05,0.01222391,-0.11016901,-0.11982912,0.02108735,0.020312104,-0.046490327,-0.06547967,-0.07798457,-0.03751202,0.04668813,0.16468407,-0.04580359 +1.14.13.135,The enzyme is involved in the catabolic pathway for the degradation of chrysene in some bacteria [2]. ,384,1.0,0.020383822,0.007832948,-0.05900244,0.0120175015,0.08536284,0.056288898,-0.010191571,0.012447436,0.011232502,-0.046769343,-0.061579943,-0.009986195,0.03777684,0.0018022255,-0.1278646,0.013908288,-0.16839646,-0.010438528,-0.006939085,0.0104691675,0.034138415,-0.008883711,-0.041040584,0.03060738,-0.009107222,-0.002002254,0.05599738,-0.078880675,-0.033303723,-0.0136854565,-0.01729088,0.03835627,0.01208088,0.015500321,0.0061035077,0.116159126,-0.033327542,-0.07494175,0.01805522,-0.025255825,-0.020569865,0.014238836,-0.07343421,-0.035587527,-0.03459721,0.000579043,0.06225531,-0.009459133,-0.02024813,-0.030180706,-0.094238155,0.0053470526,-0.04514068,0.057565432,0.009463343,0.0011315481,-0.027482623,-0.025165636,-0.033542503,-0.013503065,0.042305674,-0.012758646,0.058339346,0.012880095,0.023795694,-0.06359686,0.017022382,-0.005239652,0.028492885,-0.045925032,-0.09396583,-0.021359617,-0.014534995,-0.05141081,0.06559552,0.027459895,0.027255692,-0.09360432,-0.0057111876,-0.03996503,-0.04274939,-0.01883991,0.06587559,0.032961518,0.023230383,0.037768923,0.04978662,-0.072108835,0.048973404,0.062766895,0.061120845,0.049323574,0.002049504,-0.00628345,-0.12257706,0.030188091,0.07858779,0.017352836,0.05650799,-0.039363064,-0.028537862,0.03298862,-0.07688087,-0.071299054,-0.09923066,-0.032966025,0.04820798,0.0754508,0.025281936,-0.018818434,-0.064683884,0.055765484,0.014061957,0.011868256,0.012819868,0.08812962,0.0616271,-0.06022403,-0.03742732,0.06429586,-0.023833238,-0.011811176,-0.042673934,0.02432026,-0.07657483,0.06462888,-0.056383934,-1.9319068e-33,-0.01073658,0.08815082,0.03096039,-0.04822909,0.0072698654,-0.08885065,-0.1219914,-0.018369121,-0.035260603,-0.10349029,0.010816729,-0.051155884,-0.02986096,-0.1101883,0.027927008,-0.025367985,-0.067418374,-0.006642764,0.0630131,0.018587762,-0.0016424874,0.059544202,-0.05089812,0.010566971,0.03987283,0.031860147,0.07161497,0.10089642,-0.0060854545,-0.03140332,0.056824084,-0.044028193,-0.088557646,-0.025104253,0.059180222,-0.016516097,-0.016154528,0.019711303,-0.059304353,0.0035868841,0.029790135,-0.02248943,0.030635549,-0.0059653986,0.0461579,-0.07412492,-0.022657627,0.105601154,0.035192262,0.012059775,0.019930014,-0.023597343,0.13908109,-0.059420295,-0.02392479,0.03372955,-0.013684729,-0.12689641,0.009261705,0.035050683,0.041116815,-0.0025759572,-0.023237772,0.057599586,0.03843444,-0.024213653,-0.009613527,0.042018123,0.025894562,0.074841894,-0.11288762,0.016532796,0.05525785,-0.0014667597,0.054445885,0.0018775887,-0.08825935,-0.031752884,0.038406275,0.029375207,0.017702848,-0.06016369,0.0436485,-0.020999027,-0.03030308,-0.008513827,-0.037802547,-0.015491919,0.024349242,0.09120463,0.076950096,-0.08678576,-0.041580893,-0.0025509256,-0.0414876,3.022728e-34,0.06646316,-0.07547056,0.01225547,-0.00952278,-0.045720283,0.044201635,0.004210597,0.006037295,0.017376872,-0.027929066,0.047576215,0.024286529,0.027712248,-0.050449632,0.003775939,0.036101278,0.06912374,0.017278703,-0.021204414,-0.013679747,-0.07069563,0.081327535,-0.05957499,-0.02770222,-0.023437917,0.044610187,0.0014396731,0.1367867,0.05553218,-0.06102543,0.08576775,-0.05770928,-0.0064364774,0.013664385,-0.050649997,-0.0056554913,-0.03703048,-0.022300119,0.08205623,-0.02837064,0.030367019,-0.0415773,-0.03580654,0.0034448772,0.012923502,0.09226154,-0.0885257,0.048729647,0.049792193,-0.027626812,-0.007905747,0.04599774,-0.006971977,-0.011076705,0.036386177,0.04568179,-0.039903868,-0.026217027,0.037346907,0.024355713,0.035128266,0.0073007504,0.004373767,0.08808017,-0.020671725,-0.040543508,-0.10862209,0.080867805,0.015667692,-9.59523e-06,0.09251399,0.12335539,0.020766804,0.03234538,-0.075123206,0.030100409,0.0022095556,-0.0086793685,-0.010708739,0.0108737,0.016776644,0.005875645,0.011711744,-0.10239848,-0.06803514,-0.05460562,-0.006504384,0.07005515,0.017422365,-0.0014865845,-0.015204543,-0.08218321,-0.019151142,-0.01185557,0.020309424,-2.448674e-08,-0.011707214,-0.06892998,0.036262963,-0.10958464,0.0021885145,0.030488692,-0.0011026358,0.0052436087,0.062629744,-0.03134412,-0.0384416,0.033943176,0.07844006,0.0046093846,-0.013027567,-0.003950558,0.009584192,-0.01996589,-0.00034862303,0.007025155,-0.12797593,-0.01482472,-0.12631808,0.07336942,0.058691293,0.0276355,0.061349116,0.030990463,-0.04912419,-0.04790278,-0.009574245,-0.0009233604,0.1064842,-0.0035798387,-0.05561223,0.05973148,-0.0327688,-0.023273434,-0.019445311,0.10766698,0.124582455,0.04315185,-0.073561065,-0.0043547926,0.0017807224,0.023796244,-0.023159415,0.025909517,0.02309796,-0.0064711906,0.09173144,-0.01496501,-0.06455526,-0.024011573,-0.046841074,0.0036749276,0.0451701,-0.06596951,-0.020560345,-0.057947725,0.016396753,0.017120712,0.16577992,-0.0060932194 +1.14.13.136,"Requires cytochrome P-450. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively.",384,1.0,-0.087171316,-0.0058467784,-0.041515276,-0.023398332,0.07815742,0.04659933,-0.06708244,0.015545142,-0.021203104,-0.017485293,0.035399966,-0.08178493,-0.041886866,-0.042730983,-0.04252002,0.027520407,-0.076585196,-0.0021889228,-0.06978152,-0.02815224,0.051890355,-0.03923045,0.07160215,-0.013620218,0.0012707367,0.031892296,0.06743288,0.044033617,-0.022269124,-0.078040235,0.042992316,0.045675036,-0.018092817,-0.05448032,-0.04175341,0.058598638,-0.0043075434,-0.021639004,0.023521625,0.014578941,0.022328107,-0.07772368,-0.042919982,0.009295296,0.051581148,-0.068155885,-0.02894031,0.054523814,0.05009372,-0.016474407,-0.06578426,-0.04272415,-0.041790985,0.042478934,0.04705871,-0.018405266,0.08029663,-0.007621559,-0.04914102,-0.012137461,0.030416682,-0.013179204,-0.03649416,0.0032231286,0.005612733,-0.05641997,-0.02546473,-0.06362217,-0.02114511,-0.055575907,-0.07543918,-0.089137465,-0.014721559,-0.034495693,-0.10170807,0.054468203,-0.05591512,0.043415934,-0.021140259,0.013430345,0.055491686,-0.056159135,0.04978228,0.1077375,0.06150285,-0.014047892,-0.02461053,-0.04179292,-0.011367352,0.074360855,-0.05704051,0.04003753,-0.005583053,0.035723906,-0.038082667,0.08624897,0.024760012,0.031209262,0.04445395,-0.0016145242,-0.018602135,0.031448565,-0.054529354,-0.10941362,-0.04223311,-0.040632993,0.007442846,0.036727954,0.08239963,-0.033442933,-0.024089001,-0.08675972,-0.03689298,-0.0177713,-0.018033028,0.057904214,0.0136305,0.011854846,-0.044850845,-0.025617188,-0.033914313,0.031437494,0.05474434,0.028809402,-0.040580414,0.022466425,-0.08503595,2.1675677e-33,0.13150679,-0.043167684,-0.041279256,0.07332001,-0.023607474,-0.0076588267,-0.09816877,0.0044095567,-0.014927034,-0.094774395,-0.08165605,-0.04402586,-0.01986937,-0.015781607,-0.066673204,-0.047551315,-0.034700144,-0.03754811,0.06328898,-0.036576,0.032579135,0.034717344,-0.06877432,0.039384317,-0.017797282,0.13027959,-0.021372287,-0.016801743,-0.02546048,0.02479732,-0.016975362,-0.11315483,-0.07316876,-0.0075054844,-0.006935779,0.015000923,-0.051730666,-0.036209486,-0.05441417,0.06900391,-0.035285663,-0.07856484,0.030818658,-0.05872426,0.094873965,0.03860202,-0.04642565,0.06436291,0.06551861,0.09958702,-0.017497357,-0.021769473,0.07776181,0.082499005,-0.057179656,-0.023039619,0.0004286469,0.001475193,0.023139177,0.053374432,0.036917508,0.12536795,0.003001987,0.068869516,-0.017088668,0.06725426,-0.03428197,-0.041326996,-0.010762073,0.030788545,0.0014745458,-0.03592154,0.120696105,0.032541577,0.08964537,-0.012748097,0.03149203,-0.0076550436,0.0068761325,-0.0025921005,0.0155465845,-0.0035034823,-0.021602757,-0.017071182,-0.0664027,0.018865231,-0.0296638,-0.009438246,-0.0032599044,0.048684616,0.01912228,-0.073695414,0.01406505,-0.024004847,0.075754605,-2.819295e-33,0.078162014,-0.046884943,-0.0030480206,-0.0766296,-0.019945372,0.036488134,0.001800168,-0.04686976,-0.011511252,0.01836765,0.0029277557,-0.039386645,-0.024229443,-0.0033075572,-0.05055097,-0.0046738,0.029622281,0.019510262,0.015298815,0.014710718,0.06678003,0.06088931,0.06355641,0.08545308,0.061591305,0.041729733,0.12835792,-0.027490545,0.024502654,0.055861052,-0.085840285,0.0302863,-0.0115869595,0.02689828,-0.01872811,0.078527324,-0.041090753,0.03333512,-0.06178749,0.040161923,-0.07024117,0.019024473,0.015731059,0.037977796,0.048827402,0.075852655,-0.055501338,-0.050325543,-0.021221962,-0.04102432,0.083109684,0.10208827,-0.0022966748,0.024393952,-0.004334522,0.021102553,0.023221621,0.014038522,0.025952747,-0.014556179,0.02803811,-0.0712082,0.049479954,0.04082015,0.037439167,0.09224607,0.03345188,0.10319243,0.012491493,0.008206809,0.04473725,-0.08439345,0.10628397,0.095562935,0.008080764,0.027267825,-0.014511057,0.008959766,-0.025950015,0.014327367,-0.005622766,-0.0077333283,-0.023844393,-0.064773455,-0.07146468,-0.102929056,-0.024583206,0.00032416458,-0.02189226,-0.0013228939,-0.015686586,0.08002251,-0.05613973,0.04306183,0.09571529,-4.0557236e-08,0.013885926,-0.06795252,0.13316503,0.044137407,0.11543592,0.03158363,-0.014004949,0.044251546,0.07297984,-0.064339295,-0.049053013,0.09965527,0.05571604,0.05892973,0.067524865,-0.018681277,0.033668242,-0.013584139,-0.004145711,-0.00839142,-0.101145454,-0.024883853,-0.08209698,-0.017205948,0.008405817,-0.07590383,-0.021134587,0.024776138,0.069050886,-0.025646746,0.026786525,0.05013972,-0.041993726,-0.017394077,-0.10537843,0.019250544,-0.021989357,-0.050832063,-0.07445621,-0.0065807984,-0.12979195,-0.025827713,0.02488743,0.008307247,0.017551076,-0.0023564026,0.032877665,0.01134253,-0.018535102,0.0044786856,0.020578535,-0.0065430645,0.0058430396,-0.019254338,-0.13171303,0.031445555,0.024842449,-0.023466762,-0.0071964855,-0.053588152,-0.05482773,0.030694721,0.132914,-0.016363507 +1.14.14.11,"The enzyme catalyses the first step in the aerobic styrene degradation pathway. It forms a two-component system with a reductase (StyB) that utilizes NADH to reduce flavin-adenine dinucleotide, which is then transferred to the oxygenase.",384,1.0,0.03438434,0.033810634,-0.09478975,0.010720983,0.111646496,0.072899364,-0.05480259,-0.006027667,0.024844538,-0.06037822,-0.046389166,-0.0025415972,-0.07812373,-0.006107551,-0.035074852,0.016915012,-0.121984065,0.015230908,0.004550809,-0.06270538,0.05927865,0.03582577,0.0018767387,0.026999976,0.019172983,0.012244394,-0.019194044,-0.052469313,-0.027731296,-0.08217308,0.056709822,-0.01617622,0.07921506,-0.03505054,0.044182047,0.12341698,0.022022227,-0.04898277,-0.034994718,0.038667258,-0.012387749,0.01999935,-0.033689715,0.021080926,-0.063300475,0.027096117,0.04025341,0.06444753,-0.04134699,-0.07876771,-0.0123477625,-0.075358815,-0.07098424,0.040486675,0.052789353,0.084811814,-0.035183534,0.002641174,-0.05903568,-0.09418706,0.020294536,-0.020277003,-0.016757652,-0.014321831,0.04851788,-0.06617837,0.07821848,-0.03721668,0.024810484,0.007635283,-0.10959051,-0.037397046,-0.033120193,-0.029413072,-0.011318373,0.05774943,-0.0105891,-0.025854265,0.036779087,-0.006313182,0.034397855,0.02296403,0.05323872,0.038515843,0.07496035,0.037191126,-0.04073964,-0.041575495,0.03716258,0.016577603,0.02528427,-0.009871092,0.005046226,-0.0009216192,-0.06713291,0.013470531,0.035827637,0.033534262,0.08003457,0.008107496,-0.04369712,0.060989346,0.033632986,-0.024509883,-0.030136317,-0.0006904349,0.030020952,0.09979109,0.06321889,-0.020471377,-0.014516332,0.043299865,0.04417219,0.0044265385,0.010305169,0.09756801,0.004161383,-0.021576991,-0.094550304,-0.014012531,-0.03407446,-0.006869465,0.0012524357,0.047816686,-0.06363453,-0.001157021,-0.08971158,7.870625e-34,0.018021448,0.01902125,0.034476377,-0.021634605,0.03174651,-0.044247933,-0.0703535,0.015161668,0.039325733,0.0023554438,-0.010522088,-0.08047569,0.020005569,0.0294033,0.025102844,-0.13431902,-0.046245582,0.020216899,0.023419112,-0.048127174,0.020981008,0.017229743,-0.019097153,0.0037354059,0.054249525,0.049802326,-0.013455113,0.03589072,-0.01335802,-0.007073068,0.013514405,-0.06330509,-0.14782904,-0.009652838,0.032175645,-0.014936386,-0.069348566,-0.027536092,0.02020564,0.06509207,-0.08163667,-0.0056667724,-0.021060351,-0.027203238,-0.0077609653,-0.07416012,-0.038403552,0.14056583,0.056038234,0.032423213,0.040747896,-0.042485446,0.11291334,-0.0101735,-0.046869695,0.043052115,0.005426097,-0.08504848,-0.016824981,0.04021435,0.024900157,0.017540757,-0.03564442,0.04845803,0.031644188,0.045531236,-0.06421298,-0.012565828,0.043649342,0.06624616,-0.053747863,0.033462316,0.033255607,-0.027786542,0.018344825,0.00300607,-0.04340818,-0.034362197,0.014871666,0.0016488284,-0.042435825,-0.032296997,-0.10276142,-0.095860295,-0.04703397,0.008566583,0.029029137,-0.05925862,0.008236033,0.09199925,-0.033835337,-0.075339645,0.011103456,0.009828298,0.085451536,-1.2262255e-33,0.05402429,-0.050778616,0.046279624,-0.099985436,-0.023746286,0.04521883,0.058872495,-0.036339518,-0.024494415,-0.030676773,-0.0126171885,0.025757529,-0.012129958,-0.00035226598,0.043286033,0.032795876,-0.009933845,0.04003436,0.013697098,-0.019083358,0.008980566,0.08568644,-0.08689618,-0.0002800893,0.0019739394,0.021553967,0.00248633,0.08502419,0.11758433,-0.0043003033,-0.0009286659,-0.018799432,-0.03080063,0.03708736,-0.03553298,0.10965271,-0.06320661,0.04779855,0.022252612,-0.015866173,0.08938207,0.033237923,-0.05080235,0.044472236,0.062184516,0.112953685,-0.118857004,0.052858606,0.023957988,-0.08685813,0.07062331,0.014346805,-0.046843514,0.038664475,0.041680433,0.04739475,0.036617592,-0.058126405,-0.075341895,-0.039766215,-0.051364046,-0.025744103,0.025814652,0.07909242,0.030090338,-0.08951218,0.0022551892,0.06250717,0.016647963,0.0026040587,0.045706693,0.07609026,0.03487834,0.074971646,-0.040679514,-0.08536222,-0.083719276,0.0038723915,-0.01251631,-0.052436654,-0.005521716,-0.007817421,0.02752847,-0.122435965,0.027933592,-0.064769305,0.02483884,0.0009479557,0.032229822,0.039105024,-0.038468093,-0.008249917,-0.0025138129,0.073156476,0.04825374,-3.043853e-08,-0.006806625,-0.045215346,0.10941392,-0.031508423,0.008450374,0.050486505,0.053538565,0.05154858,0.045635384,-0.046540324,-0.043432295,0.060755916,0.11349632,-0.05015804,0.013381622,-0.0053542093,-0.06380967,-0.02903311,-0.011090934,-0.08204634,-0.090417765,-0.020053372,-0.054944284,0.08603147,0.056352373,-0.04032648,0.058029212,0.07747523,-0.015867095,0.00044960226,0.055364765,0.054768477,0.06500422,0.0353369,-0.058685396,0.0028965115,-0.0018218377,-0.044845324,-0.017835723,0.023367878,-0.057329144,0.0019929172,-0.07839749,-0.006910793,0.0061389008,0.009668425,-0.004911608,-0.004182548,-0.04007149,0.03033757,0.09463122,-0.008587933,-0.05636047,0.046973888,-0.097481675,-0.019685205,-0.0392126,0.0046758526,-0.0229312,-0.035955507,0.029957667,0.01658762,0.18452795,-0.08960555 +1.14.14.12,"This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone. It can use either FADH or FMNH2 as flavin cofactor. The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit. ",384,1.0,-0.04512471,-0.040225208,-0.1662307,0.0025631853,0.06529509,0.028733991,-0.07300727,0.062935546,-0.018163696,-0.047636855,0.003135665,-0.015957752,-0.08463582,0.039160866,0.016734278,-0.0036008155,-0.09279466,0.013843926,0.035740606,-0.05197533,0.017813137,0.019889254,-0.0391844,-0.011061537,-0.07684416,0.006922269,0.030176923,0.0074047158,-0.03770757,-0.064765476,0.08778506,-0.034002755,0.07363501,-0.02565029,-0.053869516,0.059197858,0.0026018035,-0.057287153,0.032132357,0.02137059,-0.0049554897,-0.016990101,0.053999905,-0.037946973,0.03092886,0.018068908,0.0340475,0.05891144,0.003273188,0.04905739,-0.011881388,-0.06255173,-0.0137631055,0.101338305,0.050146732,0.018329477,-0.08119159,-0.038803,-0.09592302,0.014375719,-0.015012682,0.043889534,-0.020178173,-0.014833641,0.06482889,-0.05410297,-0.023794927,-0.06470984,0.021581607,0.024021976,-0.008791985,-0.026744725,-0.04810211,0.0031280378,0.02218754,0.05237858,-0.057510935,-0.0115997465,0.08981431,0.0016667356,0.05200264,-0.025143247,0.001914345,0.13729165,0.04866162,-0.022825632,-0.029539764,-0.05428876,-0.02638932,0.07494283,0.021823715,0.039289366,0.024569267,-0.016585685,-0.10925463,0.027613025,0.014287731,0.064465396,-0.03425814,0.0023220992,-0.045573235,0.017810276,-0.0078672655,-0.008807157,-0.11394209,-0.040929776,0.04349679,0.08143962,-0.008466794,-0.004586464,0.014768353,0.0122746825,0.02172149,-0.06326076,-0.013871697,0.110423766,-0.029839948,-0.032436956,-0.132076,0.000837468,-0.0188707,-0.004656276,0.021963652,0.07685714,-0.004062198,-0.01410482,-0.10295899,7.282125e-34,0.047525402,-0.0032303976,-0.023778236,-0.026796343,-0.04180869,-0.026773544,-0.0110395895,-0.0058915815,0.026614802,-0.06320349,0.020959703,0.02120682,0.05132689,0.018221267,0.003605675,-0.070518576,-0.0068628322,-0.016330317,0.058665678,-0.015068651,0.07131001,0.08452499,0.00197628,0.016808366,0.046631783,0.029401816,-0.026326604,0.046754245,-0.077607475,0.04476661,-0.0016927735,-0.10171864,-0.07523954,0.0061290087,0.021830104,0.0057139196,-0.10123161,-0.028575182,-0.06667334,0.07597318,0.033436142,-0.018690016,-0.0499973,0.004355367,0.049580444,-0.05754184,-0.032505233,0.060876343,0.06030753,0.059789095,0.037317753,-0.03554896,0.06747901,0.016636597,-0.017975444,0.05917974,0.0026554812,-0.02507244,-0.021861091,0.01802092,0.030913416,0.043760978,-0.09324251,0.088691495,-0.04722309,0.00011397238,0.004854971,-0.13087691,-0.009223886,0.11966916,0.009572752,-0.0012571499,0.055726424,0.006716988,-0.004083713,-0.005298169,-0.0014093369,0.048192833,0.024201319,-0.045268558,0.006308463,-0.0469829,-0.029705007,-0.012472608,-0.020902317,0.027072508,0.011112633,-0.065537415,-0.016588563,0.02449605,0.043760385,-0.11297321,-0.028008904,-0.019383458,0.04043754,-1.01540855e-33,0.003791814,-0.09126945,0.023738809,-0.0813315,-0.035680994,0.13604379,0.06749098,-0.033717994,0.044844452,-0.016368026,0.026349956,-0.034266718,-0.046216257,-0.038025316,0.078126736,0.010957114,-0.0380649,-0.016644137,-0.014514518,-0.008070425,0.018238066,0.12579376,0.09732625,0.04976876,-0.02128664,0.0062989425,0.009168292,0.07674932,0.11286894,0.07208352,-0.05321408,-0.0050718174,-0.013899958,-0.047350705,-0.04420402,0.036668688,-0.038758468,0.06017155,-0.034154765,-0.03775773,0.02430376,0.019208653,0.0016792365,0.0049690604,0.014426049,0.09535645,-0.11552338,0.046727773,0.030269625,-0.031648442,0.03588039,-0.018767325,-0.047705982,0.02739661,-0.0077217417,0.010059283,-0.0015944736,0.029498635,0.010434268,-0.028792985,-0.049764857,-0.07182748,-0.00086805143,0.03927376,0.048261844,0.0052284477,0.07154813,0.0037699037,-0.014485729,0.07362403,0.051516313,0.013319102,0.081734136,0.06841287,-0.027315624,-0.018455138,-0.13243286,0.031218002,-0.018727496,0.020858502,-0.020145092,-0.0032719017,0.046980377,-0.046133604,0.012669519,-0.02402889,-0.021358343,0.09239725,0.05966868,0.04780353,0.01911761,0.0081006335,-0.041209936,-0.029605247,0.013850073,-3.2884454e-08,-0.021871716,-0.1077973,0.044807985,-0.027026992,-0.038130313,0.034759216,0.023884682,0.0057263304,0.058558937,-0.026829261,-0.013040598,0.1762724,0.066089384,-0.03407905,0.004639597,-0.003488473,-0.02122861,0.008888082,-0.03947218,-0.08465767,-0.081972405,-0.02763154,-0.020725183,0.04574171,0.0021396715,0.020946313,-0.008039903,0.04432814,0.0005748494,-0.03622459,0.06698871,0.017417891,0.07064561,0.013019037,-0.13221826,0.0036846728,0.044334967,-0.03799935,-0.070257045,0.10992827,-0.027716232,0.012482124,-0.058297206,0.02723039,0.041380838,0.0004946224,0.02970538,0.03287409,-0.015677137,-0.040156115,-0.041036114,-0.01216584,-0.088371634,-0.012389268,-0.11335795,-0.054208044,-0.006698377,-0.060679436,-0.016663952,-0.037772045,0.06807124,0.044675652,0.20020546,0.02922062 +1.16.9.1,"Contains c-type heme. The enzyme in Acidithiobacillus ferrooxidans is a component of an electron transfer chain from Fe(II), comprising this enzyme, the copper protein rusticyanin, cytochrome c4, and cytochrome-c oxidase (EC 7.1.1.9).",384,1.0,-0.04891682,-0.010036539,-0.06051827,0.054556433,0.07796688,0.046043113,-0.051247172,0.048631687,0.013796255,-0.13235919,0.004835157,-0.09404128,0.03645176,-0.0043707015,-0.073715545,-0.034475572,-0.07090515,0.023560457,-0.013099052,-0.037526213,-0.03239499,0.039406903,0.008535662,-0.043727066,-0.044673074,-0.009247124,0.103857785,-0.046159796,-0.078534365,-0.06770204,0.01609586,-0.04765155,0.045120917,0.004799983,0.017595252,0.09020668,-0.016346075,-0.07727947,0.09118621,-0.007843409,0.008479806,0.05691458,0.0148786595,-0.023111388,-0.050898135,-0.043132294,0.097294725,-0.044514805,0.018113494,0.03212651,-0.012985517,-0.03553656,-0.061000038,0.07216455,0.045247734,-0.016914431,0.022523396,-0.055571888,0.02133897,-0.0011184731,0.042134125,0.0058406633,0.025330892,0.02148283,-0.0021720561,-0.023767509,0.08525672,-0.030993327,-0.055487584,-0.10413244,-0.069005676,0.00044879928,-0.03190905,-0.031966306,-0.025683858,0.047102544,-0.0043254783,-0.046913728,0.04408399,-0.019299632,-0.05233933,-0.038969014,0.0037284857,0.15278561,0.029554255,-0.007466911,0.0014309471,-0.0024822738,-0.07897485,0.05474032,0.038806703,0.023923876,-0.020247629,-0.07047335,-0.06136539,-0.027750934,0.051478762,0.0910187,0.0076513905,0.004747144,-0.012764938,0.085983664,0.033251688,-0.11536724,-0.067753054,0.010177211,-0.0028915438,0.09553106,0.085041665,-0.008483879,0.013107668,0.022551937,0.01111903,-0.031256758,-0.020608664,0.03439206,0.021300945,-0.04271359,-0.04160685,0.05588224,0.032809317,0.009338791,0.036685985,0.0051551107,0.0018662594,-0.056480657,-0.0959983,1.4087239e-33,0.037061844,0.03515558,0.027615603,-0.032969113,0.023196794,-0.005371956,-0.062672935,0.024899542,0.0030698783,-0.023404999,-0.13951275,-0.069210775,0.022853803,-0.04073426,-0.013825655,0.025733735,-0.06400729,-0.061679304,0.033210628,0.027170312,0.064709835,0.009140693,0.01724966,-0.002261494,0.038509157,0.03453779,-0.008410301,0.019647373,-0.008626686,-0.0021445842,0.043924175,-0.054682188,-0.055425648,0.0035631757,0.081907995,-0.018708806,0.0012833565,0.016893445,-0.021560878,0.000506599,-0.017391099,0.01722071,-0.002134608,-0.055913027,0.05929364,-0.087765716,-0.06697921,0.1281299,-0.00020522282,0.120013736,0.03832183,-0.07021427,0.10330758,-0.04103424,-0.012841831,-0.011203303,-0.046266854,0.0493741,0.016437076,0.07570001,0.14930701,0.08534255,-0.04682302,0.025503496,0.027439214,0.070406094,-0.036433537,0.01265954,0.025345428,-0.0036017457,-0.050203186,0.03734188,0.030386029,0.04264043,0.0071446085,-0.036623083,-0.14005336,-0.07653929,0.090035915,0.00038118116,-0.007887221,-0.043452147,0.039231516,-0.090174325,-0.048641145,0.0044103907,-0.047851562,0.0014808208,-0.03130462,0.024696864,0.0540194,-0.09571207,-0.07934735,-0.015403218,-0.0013677634,-2.1375452e-33,0.08494646,-0.055820197,0.054647963,-0.11545477,-0.016426336,0.016808068,0.048080016,-0.011799035,0.026767267,0.02869936,0.104781084,0.009770589,0.009751991,-0.045742415,0.05428282,0.049692005,-0.044003397,0.061133828,0.05545602,0.002045721,-0.023917224,0.00351438,-0.009617849,-0.0030773175,0.06420583,0.020697387,-0.07190292,0.06009797,0.10325867,0.061598767,-0.019679725,0.04093501,0.018303841,-0.019672416,-0.07118639,0.023761742,-0.017623605,-0.021941226,0.09808377,0.030424347,0.024368657,-0.031231072,-6.787397e-05,0.1075902,0.02842043,0.06469569,-0.12591277,0.016898511,-0.010315859,-0.0052313185,-0.0004898775,0.040259764,-0.028444193,-0.010702036,0.017650504,0.086213656,0.007965593,0.04482098,-0.023646606,-0.06893726,-0.073880315,-0.035078455,0.005879973,0.07136503,0.013108829,0.055885103,-0.031022752,0.07375267,0.044501435,-0.035945777,0.061629727,0.011928371,0.013365122,-0.04905937,-0.021322995,-0.060235806,-0.0046225516,0.04171016,0.019539455,0.041195925,0.017665094,0.049525063,-0.003391561,-0.062498026,0.038467936,-0.049813453,-0.008748716,0.049773023,0.009865153,-0.099175446,-0.057610888,0.012963787,-0.021891702,0.015986225,0.010659494,-3.5180793e-08,-0.008106326,-0.092863984,0.028854558,-0.041200437,0.039090633,0.015712583,0.0028871545,-0.016116232,-0.033556327,-0.02295382,0.017126868,0.13958831,-0.052327592,-0.055109046,0.00779486,0.012387833,-0.023556635,0.03728408,0.016095797,0.012791526,-0.05167475,-0.005559288,-0.09160968,0.0664043,0.02828374,-0.07867678,-0.01253673,-0.04890194,-0.015488653,0.011307548,-0.0014027831,0.005673899,-0.012394339,-0.06978831,-0.0792601,0.00058779545,-0.02766879,-0.013261769,-0.015572312,-0.0024062323,0.0066939183,-0.015043779,-0.109141976,-0.054118834,0.04782457,0.014631747,-0.018998036,0.07890367,0.005275337,-0.0017794622,0.028808163,-0.03829453,-0.008677579,-0.02938118,-0.067412935,0.077063315,0.075500146,-0.07427942,-0.019686341,-0.028271353,0.02694161,0.029191496,0.20350105,-0.040966533 +1.17.1.7,"The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 3.3.2.12, oxepin-CoA hydrolase.Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway.",384,1.0,-0.08180422,-0.06267593,-0.007487644,0.012544114,0.13008367,-0.02289423,-0.054026008,-0.011878113,0.045664754,-0.09022036,-0.008057244,-0.06420435,-0.05899351,0.048440296,-0.010605396,0.02688803,-0.09329661,0.038552277,-0.05613172,-0.08307909,0.055156432,0.0047603804,-0.02900411,0.052911136,0.059043337,0.0055203093,0.052072648,0.014288414,-0.044770952,-0.07190676,0.03566716,-0.059197206,0.022443486,-0.027961943,0.074252285,0.050830975,0.03828969,-0.1557928,0.07623355,0.012861575,0.0073554036,0.023082439,0.0143295415,-0.061468717,-0.0015205691,-0.043141756,-0.013044325,-0.021006254,0.08328303,-0.037530378,-0.022633696,-0.050508752,-0.06138462,0.019579552,0.045449246,-0.0015696702,-0.015240414,-0.07510546,-0.02545029,0.0190424,0.015454492,0.0214101,0.052498627,0.046628147,0.009526261,-0.113926604,0.037303638,-0.05134393,0.0060587847,-0.026125304,-0.11194009,-0.07673991,0.0666401,0.04550259,-0.0043471702,0.00797744,0.01690229,-0.08275942,0.012650685,-0.0020520212,-0.030222997,-0.0033021308,-0.03015098,0.078768015,0.009251791,-0.064699516,-0.038131658,-0.05399572,0.007930357,0.014984273,-0.034325503,-0.008527498,0.03417716,-0.0060034823,-0.008401594,0.06783832,0.017863898,0.005746764,0.023614038,-0.011023114,-0.0515871,0.1328293,0.0323476,-0.07037486,0.024168665,-0.021249946,0.0038691168,0.18996567,0.040348712,-0.008823647,0.015381299,-0.07494844,0.10277002,0.00983293,0.020710941,0.10018146,-0.0177471,-0.018947078,0.0038498568,0.041743744,0.021816544,-0.0391606,0.0565715,0.059029106,-0.0529777,-0.004129037,-0.05176672,3.130067e-33,0.0669013,-0.0044790227,-0.005997899,0.023440756,-0.014358645,-0.030873789,-0.1059585,0.051876202,-0.03395338,-0.013181554,-0.018657085,-0.024512429,0.06977803,0.019743199,-0.018740784,-0.10486126,-0.030352352,0.016444879,-0.0052253664,0.069048785,0.014994247,-0.0053335456,-0.0049154866,0.03952839,0.050898135,0.06654408,-0.0090199495,0.025846468,0.026178526,0.018440006,-0.009281445,-0.04875091,-0.115846194,-0.000645892,0.012117007,-0.08016247,-0.06431713,0.0058655716,-0.011847171,0.0905833,0.04097263,0.010544351,-0.050778788,-0.06372795,0.06592188,-0.0075324224,0.015241488,0.11215535,0.024157882,0.03340545,0.027753932,-0.026700938,0.11750703,-0.0647654,0.000689687,0.01779127,-0.024011813,0.027230091,0.087672696,-0.0070648068,-0.012763415,0.0875835,-0.055944946,0.06120789,-0.017204287,0.028895773,-0.012148631,-0.06749708,0.035263136,0.09656637,-0.060323138,0.06496681,0.030590866,0.012449057,0.0776521,-0.08319228,-0.04392708,0.032399412,0.046572026,0.032306265,-0.0043808552,0.019752046,0.0040325793,-0.029464751,0.00037823548,0.051454075,-0.01679933,0.03394609,-0.017087251,0.08983271,0.065553196,-0.106813796,-0.0025030037,-0.041941646,-0.025190402,-3.0023048e-33,0.109089136,-0.122231714,0.0029416513,-0.15188907,-0.10577792,0.021243952,-0.028524142,0.020788468,-0.022131938,-0.017288545,0.06267439,0.018330654,0.035298936,-0.05153703,0.0025999253,0.01740159,-0.041617237,-0.0016344097,-0.0043218397,0.024185698,0.06472598,0.032089572,0.01491859,-0.016023323,0.08363018,0.03471379,-0.01483512,0.015403318,0.049383007,0.012731568,-0.056510646,-0.053938616,-0.021743521,-0.002159386,-0.06815923,0.053975116,-0.08669265,0.024174716,0.03141868,-0.014623969,-0.014097639,0.025030011,-0.042231426,0.029173324,0.034290213,0.06706749,-0.040029682,0.0039167167,0.036029425,-0.028909096,-0.009095095,-0.059241887,-0.06939468,-0.03495553,-0.025795765,0.021095969,0.020051321,0.020206556,0.0016949987,-0.042193897,-0.04082656,-0.040261872,0.09859726,0.031074313,0.020221027,0.10494244,-0.043364555,0.07848127,0.036083557,-0.00049890054,0.07520686,0.007145204,0.05577391,-0.0032291592,0.02766477,-0.0322355,-0.051052146,0.025215972,-0.024938442,0.04223509,-0.06375649,-0.043669906,-0.04376815,-0.040670462,-0.030389626,-0.06321479,0.032745983,0.09039792,-0.0066497787,-0.002208975,-0.0059300964,-0.044625215,-0.03744762,0.021106217,0.037415843,-3.6581508e-08,0.003568299,-0.07108382,0.05908904,-0.023997065,0.06348299,0.09234021,0.00164114,-0.02844331,0.067825995,-0.010185845,0.037418593,0.072430626,0.047926906,-0.013784214,-0.002633341,-0.06704528,-0.029796591,0.0223992,0.024203978,-0.031939283,-0.013878206,-0.02088246,-0.045947462,0.092039876,0.048518334,-0.023530088,-0.0054331603,-0.018907744,-0.053467285,-0.081987105,-0.03216673,0.03540215,0.005128443,-0.0029295597,-0.033107046,-0.026179252,-0.0048390077,-0.023488285,-0.09852076,0.058160756,0.006982371,0.0067585027,-0.11235212,-0.028339092,0.02965251,0.057492685,0.013404012,-0.009263048,-0.037976656,-0.042441513,0.08464706,-0.066463135,0.005690408,0.02735824,-0.07211036,-0.028287368,0.009799915,-0.1077199,-0.054514077,0.0044850153,0.037305743,0.011885256,0.19699466,-0.026583087 +1.17.7.2,"Contains FAD and an iron-sulfur center. This enzyme, which is present in plant chloroplasts, carries out the second step in the conversion of chlorophyll b to chlorophyll a. It similarly reduces chlorophyllide a.",384,1.0,-0.060223382,0.037051324,-0.08297965,-0.007616409,0.14824449,0.0855463,-0.0033668932,0.0011665258,0.04783447,-0.008936144,0.0350846,-0.044069484,-0.06225761,-0.04358054,-0.02537871,0.034984797,-0.14839819,0.06319798,-0.083646946,-0.055447865,0.024027348,-0.018674036,-0.030017264,-0.008570291,0.029550558,0.0066714245,-0.031107685,-0.013865939,0.0024006905,-0.08699854,-0.035128403,0.0689909,0.042247847,-0.020313097,0.0037249273,0.05963099,0.05331759,-0.10922085,-0.0021572146,-0.009217288,-0.01615952,0.018316388,-0.022499613,-0.039397113,-0.032116424,0.05252609,0.025349073,-0.014432742,-0.042694706,-0.059884887,-0.010012643,-0.039657433,-0.094252564,0.03729547,-0.02679207,0.057534225,0.04583707,-0.0072448035,0.045814704,0.01287348,0.005101202,-0.040606555,-0.037436746,0.008459949,0.028786497,-0.03603018,-0.0049716057,-0.07758162,0.013116261,-0.060153082,-0.03161743,-0.034028072,-0.048489586,0.010645555,0.025919037,0.0051583713,-0.0093001975,-0.06580482,0.039157163,0.011316786,0.023610927,0.05197426,0.01794967,0.09747655,0.04523492,0.008510195,-0.031330045,-0.04165735,-0.044877075,0.021363104,0.05649778,-0.031766497,-0.049813967,-0.015315916,-0.08870043,0.13947734,0.030240178,-0.08035158,0.025127951,-0.031333808,-0.022215113,0.03881837,-0.034143604,-0.12215014,-0.063277856,-0.01472525,-0.040561993,0.09954004,0.002247783,0.0170124,-0.011454888,0.01288753,-0.0065110177,-0.0050491127,-0.0039996724,0.04135552,0.12669553,-0.060958862,-0.044879217,-0.016500222,0.0043460336,0.042710066,0.016398001,0.10026565,-0.006251294,0.022758596,-0.15541457,2.4191264e-33,0.049996898,0.0058868234,-0.018525932,-0.030629074,-0.03370284,-0.04414805,-0.07129187,0.020231934,0.035583638,-0.050965607,-0.065304264,-0.073203824,-0.018782645,-0.06267072,-0.03208182,-0.050075483,0.000828443,-0.0014802348,0.008224159,-0.038584847,0.019077465,0.114646815,-0.0354446,0.018561086,0.0486578,-0.005641119,0.017298391,0.015140897,0.041557346,-0.03578042,0.04549622,-0.064466655,-0.07805117,0.041704293,0.065795116,0.06554317,-0.043210927,-0.017707065,-0.053785704,0.07736698,-0.0049384693,0.034293238,0.00019378398,0.019696157,0.11354159,-0.06915411,-0.08311293,0.052486755,0.062130447,0.06091189,-0.012170395,0.027605206,0.058602367,0.026008118,-0.06672942,0.05401963,0.03097934,-0.026723154,-0.0269259,0.079636276,0.010217371,0.04064149,-0.024681881,0.05550845,0.030291522,0.00047505228,-0.06097046,-0.040990375,-0.005598084,0.08408746,-0.09181024,-0.045337785,0.057880566,0.041112628,0.09263888,-0.04721256,-0.016939824,-0.009909938,0.00021084753,-0.014236241,-0.019173708,-0.012946771,0.043252245,-0.07853035,-0.08197305,-0.054606706,0.0020345058,-0.06383413,0.016810529,-0.05044297,0.058140147,-0.06980761,-0.013352211,0.022133246,0.004497757,-3.301674e-33,0.05223256,-0.07283701,0.0915174,-0.041384984,-0.05984797,0.031310476,-0.021086184,-0.13145824,-0.02167023,0.036894046,0.059033044,0.027785672,-0.021035824,-0.022892728,0.01966271,-0.00446273,0.08839702,0.09049751,-0.0026648853,0.053509213,-0.10085828,0.09521934,0.071080655,0.033079784,0.021965116,-0.02789661,-0.014471236,0.017592134,0.1175817,-0.011171971,-0.011928987,-0.03147318,-0.04413429,-0.0019807585,-0.06910634,-0.07335711,-0.035392042,0.029631304,-0.009001562,0.061229076,0.020829856,-0.042185996,0.019656232,0.0738459,0.025603032,0.017432671,-0.084883556,0.03581013,0.010164834,-0.01965975,0.010756461,0.026287531,-0.014751486,0.027121989,0.06833743,0.020486632,0.048085097,0.024912795,-0.03322698,-0.009103348,-0.03014325,-0.06956582,0.038903706,-0.004098334,0.06962353,0.08450587,-0.004314637,0.106357135,0.009784245,0.046517223,0.04778666,0.100335136,0.067269266,-0.024282958,-0.031238288,-0.05430038,-0.0066722077,-0.0014621111,-0.024987366,-0.015370865,-0.02278452,0.023669962,-0.037993252,-0.04382928,-0.053060677,-0.085915715,-0.010692682,0.052717276,0.010723211,-0.002180226,-0.03591586,0.030669684,0.046728056,0.023006976,0.081369475,-3.55318e-08,-0.061953142,-0.029882722,-0.016309418,-0.04676845,0.017887961,0.026994577,-0.039923813,-0.01568662,0.015973587,0.017379418,-0.11257986,0.13831902,0.031235619,-0.021722589,0.03167912,-0.0027751229,-0.0068290066,0.030965997,0.033641923,0.01888635,-0.0832101,0.0067020017,-0.116781205,0.08223828,0.039188728,-0.040979158,0.047329,0.038096737,0.050074894,0.042257395,0.04457149,0.0065265456,0.004367588,-0.032870285,-0.02836736,0.011848397,0.03633508,-0.047304414,-0.0695156,0.0745922,0.039357994,-0.0061977534,-0.0700093,0.023382645,-0.012558374,-0.044755287,0.013271067,0.032871056,-0.004332181,0.045522302,0.08986469,-0.053657282,0.026467135,-0.08620849,-0.121230416,0.015424164,0.04246734,-0.08186911,0.00028502327,0.03186578,0.021516629,0.026035747,0.14007774,0.06400282 +2.1.1.234,"The enzyme is involved in the biosynthesis of desosamine, a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics such as erthyromycin, azithromycin, and clarithromycin.",384,1.0,-0.040184952,-0.0039210976,-0.07935224,-0.08098047,-0.0036061592,-0.027084801,-0.019565992,0.0754803,0.02039759,0.08589138,-0.011308795,-0.06033281,0.058711216,0.056026325,0.011785629,0.016476216,-0.08319172,-0.010047727,0.0052180425,0.020525753,0.11005038,0.043743424,0.0043645455,0.048363518,0.0530421,0.039257746,0.060042802,0.012098376,-0.028026357,-0.08755978,0.008908281,-0.055067826,0.08791469,-0.02830891,0.084665366,0.028489647,-0.07376792,-0.018080514,0.09266742,0.02038725,0.00031243436,0.051159885,-0.0146784475,0.0036103595,-0.05053612,-0.045031108,-0.0800355,0.07109448,0.07752302,0.006982039,0.025731498,0.005963482,-0.043787707,0.100464694,0.09648029,0.020429663,-0.046877574,-0.006789874,-0.070350565,0.023661416,0.09324651,0.017118221,0.024810083,-0.025273941,-0.041307803,-0.034244668,0.049427204,-0.047398247,0.047925185,-0.017267816,-0.055478986,-0.07934812,0.0392565,0.023573112,0.00405035,-0.025858624,0.015324741,0.007630708,-0.09194361,-0.06527623,0.04358911,-0.013820494,0.06810831,0.10773728,0.05469376,0.02337647,0.049698137,-0.029986009,0.097451575,0.007302107,0.0069419,-0.026812015,-0.02485138,-0.039378244,-0.046175353,-0.040613703,-0.01849917,0.051100798,0.0447101,0.0012455521,0.036292583,0.022807257,-0.016002417,-0.08932959,-0.002820992,0.039868318,0.031816714,0.033081442,-0.018558573,-0.013163906,-0.016139878,0.016905949,0.058801528,0.09396074,-0.07229604,0.06700294,0.0648732,-0.09627554,-0.06701209,-0.0032653706,0.050619397,-0.01366101,0.018692048,0.030917566,-0.023641385,0.031229746,-0.109988436,1.9546076e-33,-0.01817683,0.060005624,-0.04373418,-0.03928034,0.027570501,-0.009723108,-0.034515597,0.045612812,-0.1211366,-0.029123431,-0.10144137,-0.052346416,0.08300853,0.07762141,-0.05921539,-0.027723331,0.028533988,0.010938147,0.012528334,-0.00044138177,0.032151323,0.020095032,-0.114524536,-0.041946933,0.0024896984,0.10546695,-0.03491135,0.057005458,0.10308283,-0.021863174,-0.019292124,-0.11445136,0.018712632,0.013798521,0.07478144,0.0037459428,-0.079688154,-0.01776698,0.042772952,0.039732,-0.01888392,-0.011088037,-0.02816842,-0.041838147,-0.01766623,-0.0149847325,-0.05226442,0.07193718,0.0565365,0.035938628,0.06590882,-0.067756094,0.0550794,-0.030939799,-0.058430705,0.04481647,-0.03319695,-0.038826372,0.02879898,0.009207301,-0.015718564,-0.019222772,-0.079500064,-0.05452201,0.09259894,-0.0024301438,-0.038807653,-0.0034686723,-0.01598618,0.03616035,-0.122105,-0.054437082,0.0382371,0.005198628,0.051090006,0.02151428,-0.089207955,-0.008632684,0.060079295,0.020013042,0.0024971422,-0.04632683,-0.050494265,-0.06771854,-0.051417816,-0.010791474,-0.024993777,-0.07322706,-0.030073782,0.09060113,0.0059891418,-0.14042538,-0.049284086,0.0054770964,-0.008415842,-4.0742928e-33,0.062457714,-0.0040828167,0.02886679,-0.026162678,0.0006060239,0.0857276,0.015322136,-0.0107646445,0.015679477,0.010298856,0.10608495,-0.014663332,-0.055592284,-0.016530298,0.026147088,0.065817736,0.047783047,0.0165537,-0.008243231,-0.038994923,0.024290664,0.040741537,-0.05132886,0.0016197099,0.010391905,0.025724396,0.064178355,0.040453378,0.046501942,0.039422106,-0.07674666,-0.0855896,-0.046281498,-0.023847193,-0.06831502,0.05254424,-0.054921784,-0.02065841,-0.021345966,-0.05706643,-0.034123253,0.011315091,0.015120123,0.07520593,0.050668404,0.056942783,-0.073184855,0.053327624,0.016787902,-0.0023058916,0.055099342,0.019149028,0.041163623,0.016601928,-0.047384586,0.030382667,0.04217937,0.006306043,-0.0065367683,0.016274583,-0.031573057,-0.031674307,0.028235722,0.025766578,-0.0026843837,0.024301765,-0.07971268,0.05045903,0.02142774,-0.03192441,0.01909845,0.046819385,-0.04574062,-0.04464691,-0.093078785,-0.029594095,-0.12215285,-0.08150762,0.0088221375,0.0048338147,0.017612683,-0.0010303683,0.001590311,0.006172593,-0.09010382,-0.019410497,0.020866212,0.054058652,-0.010349397,0.007884122,-0.032180477,-0.025230277,-0.046900462,0.0726523,0.07149135,-3.6925186e-08,0.050110206,-0.027204234,-0.0017230887,-0.039640244,0.006511673,-0.009969656,-0.035926744,0.00947976,0.0038586054,-0.00069468905,0.043237906,0.08104811,-0.0374661,0.011061838,0.033055045,0.022244068,0.0030158362,0.023372483,0.0090856645,-0.03589572,-0.018004585,-0.025254365,-0.11311519,0.05789851,0.074769765,-0.019093513,0.0278917,0.009972857,-0.02146804,0.04384317,0.0039972155,0.035234783,-0.04999385,-0.040301938,-0.055069856,-0.054837275,-0.10133441,-0.07042287,0.025338162,-0.027742483,0.09296003,0.029015418,-0.055207655,0.03429237,-0.0067338594,0.023474082,0.03813194,-0.048183013,-0.01470268,-0.020952215,0.049960222,-0.008692995,-0.026274676,-0.027681129,-0.1101083,0.0034291793,-0.029348424,-0.08536473,-0.0483558,-0.01702327,-0.05623898,0.027824504,0.26692677,-0.04489522 +2.1.1.235,"The enzyme is involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin, which is produced by the bacterium Streptomyces fradiae.",384,1.0,-0.013324707,-0.020486308,-0.08790024,-0.0008571688,0.059345882,-0.008541593,0.0414235,0.1276451,0.05014048,0.038186524,-0.013292944,-0.03603814,-0.015238372,0.112862416,-0.036426853,-0.0016999082,-0.06742764,-0.026740197,-0.038162317,-0.016901549,0.0312692,0.053626668,0.046566743,0.029944725,0.032578222,-0.034834325,0.014884503,0.05600962,-0.021584354,-0.04008729,-0.023434836,-0.03248992,0.102996804,-0.036177173,0.07691056,0.051080123,0.028382216,-0.09216983,0.09586674,0.0033290528,-0.02154599,-0.026689759,0.03683033,0.047354583,0.034076445,0.07201434,0.07966123,0.065084144,0.050393723,0.012174924,-0.14222482,-0.032992102,-0.021185502,-0.0020115213,0.037269764,0.08047404,0.015823247,-0.038392425,-0.0072789206,-0.039270055,0.05740521,-0.031256605,0.009214263,0.019694395,-0.05915567,-0.029751683,0.017644675,-0.008127851,0.018513545,0.021363586,-0.054011174,-0.06383897,-0.056272004,0.09254244,-0.0015548307,0.017302938,-0.013333123,-0.018224178,-0.044630986,0.009309718,0.04983422,-0.0049051037,-0.013041204,0.061411005,0.0028911538,-0.033082325,0.13429248,-0.012067555,0.10063858,0.03606576,-0.0038596597,-0.07543292,-0.047685076,-0.08199635,-0.045335658,-0.050531685,0.013449703,-0.00975028,0.05449951,-0.021482604,-0.013773666,-0.0062829973,0.016896836,-0.011720074,0.015180071,0.06393851,-0.05208208,0.055314254,0.09336082,-0.054499682,0.009967328,0.01862196,0.043439455,-0.010814683,0.0018869425,0.063300356,0.10688598,-0.07419664,-0.059188697,0.02390619,0.08129392,-0.009085714,0.0020379208,0.043503743,-0.08999091,-0.0057713133,-0.075362496,3.8704984e-34,0.026650062,0.008115205,-0.022668645,-0.009245046,0.06700356,-0.041695654,-0.09670241,-0.052531924,-0.10644935,-0.033816196,-0.0767696,-0.15165804,0.03710832,0.08484374,-0.054925486,0.058490958,0.008453934,-0.00908703,-0.0017741519,0.052203886,-0.0062981327,0.060677394,-0.06723363,0.021652523,0.007668865,0.12917896,0.011114637,0.03372459,0.07519415,-0.053003296,0.082483955,-0.025495896,-0.105067976,-0.001630481,0.08439016,-0.05166327,-0.04676568,-0.0680078,0.056033954,0.012314661,-0.018350923,0.031090043,-0.017569944,-0.052748673,0.07581442,-0.08663623,-0.024794599,0.048487473,0.063067,0.0340118,0.089957364,-0.036439847,0.066941254,-0.030493205,-0.02410739,0.0020892164,-0.018124884,0.049674768,0.04594879,0.010107079,-0.07627741,-0.035723273,0.009283312,0.05819814,-0.030064145,0.00050018425,-0.0021743604,0.010141424,0.024831645,0.04995951,-0.02494067,0.011131503,-0.0036151612,-0.04050761,-0.018771227,0.047097817,-0.09494593,-0.03578389,0.004453991,0.008191127,-0.07408914,0.02620376,-0.018950231,-0.02504699,-0.036290072,0.027955754,0.018707464,-0.060399745,-0.07539816,0.02703167,-0.061541863,-0.058512516,-0.07758429,0.0062349406,-0.032724276,-2.2246778e-33,0.08521275,-0.042046238,0.039742067,-0.11635746,-0.120322235,0.014147483,-0.05347313,-0.017784266,0.038617153,-0.027267326,0.0033694657,-0.07584026,-0.00848417,-0.03293941,-0.014557493,-0.0007251098,0.0218342,0.015365782,-0.07550252,-0.013178916,-0.024620885,0.07078033,0.05124302,-0.027200287,0.059939157,0.013108261,-0.027676826,0.10296459,0.051264938,0.035848267,0.004322439,-0.08722379,-0.011803336,-0.1139646,-0.017246986,0.11423329,-0.047330342,-0.0185607,0.08362064,-0.04150481,0.060171783,0.011846034,0.01858272,0.01770656,-0.060831815,0.08865136,-0.10560439,0.040405218,-0.0140997525,-0.09111613,-0.0072277337,-0.010095146,0.06563451,-0.010947265,0.016755184,-0.0027747015,0.05597367,-0.014314789,0.022019206,-0.054819338,0.01223104,-0.03499526,0.0674494,-0.020042699,0.031784937,0.078439295,-0.04477405,0.042429958,0.051881343,-0.04594426,0.07959919,0.036580075,0.007843439,0.09647803,-0.0144038815,-0.01228974,-0.052410785,0.006511045,0.023849405,0.023340585,-0.041978747,-0.053073365,-0.0072398093,-0.04437883,-0.044689182,-0.047704518,-0.0063847867,0.06535351,0.024170939,0.02380354,0.004331355,0.027036134,-0.037627127,0.021707987,-0.0009932513,-2.798628e-08,0.06911879,-0.08516444,0.016677119,-0.03970208,-0.00282935,0.011011352,-0.028582724,0.048853673,-0.0019422774,0.018511822,0.018608177,0.02102199,0.020118477,-0.06484215,0.008588844,0.018362425,-0.05361098,-0.06705045,-0.02667668,-0.030763248,-0.052509196,-0.0021035008,-0.060272425,0.048799228,0.038323283,-0.067493804,0.0047209766,0.008962901,-0.041281447,-0.021343376,0.022824975,0.0493758,-0.00010188591,0.022621643,-0.096575096,0.021093689,-0.09677269,-0.04654306,0.037886206,-0.02489714,0.060953803,-0.0068870895,-0.02879992,0.011923141,-0.10484304,0.03177246,0.017895753,-0.009646032,0.0060113287,0.003285716,0.05887644,0.061096605,0.0048974073,0.06587398,-0.12399642,0.042897344,0.03598398,-0.020824753,-0.022375077,-0.053351182,0.00959016,-0.023970446,0.17143354,-0.05920842 +2.1.1.236,"The enzyme is involved in the synthesis of dTDP-D-ravidosamine, the amino sugar moiety of the antibiotic ravidomycin V, which is produced by the bacterium Streptomyces ravidus.",384,0.99999994,-0.05830527,-0.018222678,-0.07226949,-0.05292021,-0.001285298,0.042365927,-0.037815172,0.09026293,0.06538887,0.08119756,-0.017973427,-0.009288525,0.06106549,0.0716665,-0.011763105,0.005242533,-0.018756311,-0.017481957,0.10778456,0.0054835365,0.096921735,0.088742085,0.026870055,-0.05771632,0.08933452,0.08466515,0.07432022,-0.009087518,-0.039769072,-0.009449329,0.02078086,0.013261603,0.042505212,-0.043281253,0.040631335,0.04923134,-0.04072956,0.0121178385,0.0722413,0.009709848,-0.012263992,0.04746336,0.02446908,-0.026922472,-0.055517673,-0.009566625,-0.04519851,0.09749164,0.040814728,-0.058777742,-0.01593326,-0.005511196,0.02262443,0.017384058,0.09124853,0.046802573,0.047757883,0.025431668,-0.04798733,-0.03141723,0.052121807,0.04727872,0.01592991,-0.044223666,-0.029280918,-0.0102720475,-0.0015846865,0.017765721,0.06004086,-0.0085009765,-0.09648064,0.04266484,0.037150387,0.013770534,0.030575056,-0.07548075,-0.0065366407,-0.05911284,0.00488517,-0.112133585,-0.024592882,0.029179463,-0.0082420455,0.10114458,0.011810122,0.06553359,0.0672597,0.04752149,0.052501414,-0.011364687,0.049848974,-0.041966893,-0.09304244,-0.06402157,-0.13969527,-0.020424278,-0.053143848,0.023215102,-0.0025622598,-0.023510976,-0.0061452948,0.009632892,-0.03840964,-0.0683228,-0.035015244,0.011722741,0.03316112,0.061736487,0.01738026,-0.053044792,-0.020586953,0.05625504,-0.003515016,0.053786945,-0.099467695,0.036127537,0.028284518,-0.04535267,-0.121018805,-0.053915475,0.050981894,-0.022496551,-0.02701356,0.083165504,-0.044849552,-0.031273957,-0.053575125,-6.066865e-34,0.03295324,0.056987423,-0.010795854,-0.051731497,0.046771076,-0.061441947,-0.032622606,-0.012157669,-0.0073535168,-0.0063411817,-0.09384636,-0.12932682,0.008733509,0.10476035,0.008254478,-0.07883219,-0.020561183,0.060675144,0.072216235,-0.011976943,0.005709989,0.10463307,-0.018074265,0.037711244,-0.034815747,0.08850039,0.024825765,0.073674716,0.14193693,-0.0056898305,-0.05356745,0.0021085744,-0.031596623,0.009470646,0.046057176,-0.0015097634,-0.09486635,-0.0500192,0.028733801,0.027943157,0.042440627,0.01766598,-0.043559857,0.060965553,-0.033953417,-0.015261251,-0.018722242,0.06010377,0.06264555,0.03112719,0.056515265,-0.032108866,0.072740376,-0.047723908,-0.061771397,0.022768147,-0.0789673,-0.05171518,0.052457836,0.034044858,0.020325143,-0.06507911,-0.040033508,0.03137272,-0.051662434,-0.021898838,-0.008685109,-0.08871377,0.04781258,-0.0015067055,-0.050024036,-0.027121764,-0.018247128,0.07737025,0.011414188,0.008411074,-0.0214329,0.0027531956,0.080389954,-0.041127592,-0.039817948,-0.0035820107,-0.031858485,-0.09788745,-0.018605636,0.0716744,-0.04688222,-0.07475949,-0.026407627,0.07271019,-0.06787079,-0.09841357,-0.052435186,0.028709538,0.027841799,-1.5526859e-33,0.010582089,0.005911684,0.028514262,-0.058562156,-0.050486527,0.06694344,0.018927876,-0.012007985,0.03522385,-0.07544548,0.0541592,-0.03830123,-0.06490435,-0.07395583,0.008748505,0.038567018,0.020745013,0.06752812,-0.08952904,0.00017491309,0.0040560993,0.03073778,-0.0037149296,-0.04153144,0.022076355,0.06344867,-0.010413786,0.08400165,0.0024469655,0.09567872,0.08377665,-0.04695891,-0.103908345,-0.033908073,-0.033390928,0.12121898,-0.028253984,-0.018248305,0.017746333,0.014948438,0.011010169,0.016269919,0.040186156,0.08078505,0.03296988,0.030763207,-0.07520836,0.04080911,0.028721035,-0.053432617,-0.018192763,0.021274261,0.08167236,-0.036744528,-0.028696314,-0.033912417,0.016967189,0.025724147,-0.011704116,-0.04263576,-0.016923696,-0.022734266,0.02818042,0.0055539426,0.025513489,-0.013002604,0.032253746,0.011313366,0.073507115,-0.040087983,0.03373468,0.002812069,-0.049967457,0.016578145,-0.061593752,-0.08337615,-0.11756171,-0.025942607,-0.006939871,0.03321909,0.008762467,0.040212717,-0.033532336,-0.03523569,-0.08646569,-0.0326221,0.09471002,0.031468917,-0.014469626,0.04706939,-0.08963738,0.021148715,-0.023080492,0.053425774,0.093705304,-2.8871789e-08,0.07981874,-0.05412474,-0.0033613273,-0.050748996,-0.0062191687,-0.026739007,-0.087206684,0.02656173,0.03706649,-0.080581285,-0.023729831,0.060317896,-0.0087443115,0.0008466745,-0.027721029,0.0013708684,-0.06392104,0.028149776,-0.037890732,-0.051927034,-0.013596896,-0.003614189,-0.068328485,0.0009747006,0.027212042,-0.011278065,-0.0072232783,-0.05826313,-0.029422546,0.015410138,0.07562688,0.022993073,-0.07191666,-0.0062529803,0.014470568,0.024282148,-0.079246484,-0.022357339,0.07863527,-0.007828472,0.040717095,0.05332477,-0.038902476,0.07325501,-0.0074267513,-0.015278057,-0.049316484,0.0023340704,-0.06207031,0.016717969,0.036719233,0.053548433,-0.03851514,-0.069170624,-0.12354626,0.0044206367,-0.024746317,-0.063518144,-0.055069204,-0.045298643,-0.032224007,0.006026,0.15159863,-0.035794027 +2.1.1.237,The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. 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+2.1.1.238,The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. Requires Mg2+ for optimal activity. ,384,1.0,-0.055301636,-0.009784645,-0.044859756,-0.033855464,0.039356913,-0.057349324,-0.02819231,0.11472426,0.010682306,0.012926071,-0.023978708,-0.034835715,0.087859415,0.06666104,-0.059783265,0.030552018,0.019112423,0.039715186,-0.040812276,0.010897084,0.028821835,0.060564224,0.033009302,0.038697843,0.011331215,0.021452608,0.05772148,0.044336893,0.0030403347,-0.016849333,0.021687495,-0.020186042,0.0985536,-0.060765,0.060990874,0.03727477,-0.08939192,-0.01678067,0.08143511,-0.044063482,0.020246314,-0.008881139,0.1099867,-0.05364254,0.04354,-0.022245387,0.011108833,0.02413179,0.06740197,0.09487119,-0.10700262,-0.013667811,-0.06360947,0.06122415,0.05479515,0.0044127284,-0.08751108,-0.014756426,-0.06770673,-0.035181623,0.010609233,-0.033721376,-0.010432576,0.041652657,-0.054566644,-0.036972247,-0.008676051,-0.018555352,-0.010069,-0.015355748,-0.051500037,-0.08417171,0.011270252,0.05468096,0.02471115,-0.024073355,0.030547643,-0.040383395,-0.008562515,-0.025177153,0.0062349737,-0.05671552,-0.006333216,0.06351175,0.044126432,-0.024962407,0.15336901,-0.0009609603,0.07292261,0.11205837,0.106856,0.022907319,-0.031418066,-0.010197585,-0.05201115,-0.02409385,-0.040644575,0.03306577,-0.006622402,-0.009650261,-0.008075261,0.011305102,-0.007963835,-0.044433564,-0.06297124,0.0017076898,0.0050288793,0.021891903,0.06301056,0.0081788385,0.046943713,-0.017852554,0.015989667,0.0064830994,0.020365668,0.12952712,0.06987158,-0.0742398,-0.02514325,0.0042049033,0.035509937,-0.010941598,-0.011645824,0.006054817,-0.11033375,0.006676897,-0.040710285,-5.466848e-34,-0.04016629,-0.0061486918,-0.048369344,0.0006648234,-0.0050638947,-0.061112475,-0.108260736,-0.008036606,-0.05841048,-0.07288405,-0.08108425,-0.08443182,0.010685588,0.094143815,-0.056326035,-0.034683548,0.06055871,-0.015721612,0.06312731,0.05010777,0.033211738,0.0275901,-0.042242102,0.06147832,0.07409466,0.15338576,0.023638839,0.0021393094,0.03428425,-0.01612085,0.026950203,-0.09817711,-0.09143004,0.037210606,0.048482127,-0.010365711,-0.005962251,-0.07939917,0.030888742,0.04638872,-0.077514656,-0.028975764,-0.029006328,-0.024975393,0.088847086,-0.053439226,-0.01925457,0.064035155,0.03215366,0.058179136,0.15007716,-0.06358583,0.05972156,0.0060564172,-0.03425309,0.054420613,-0.058091644,0.06735325,0.066140406,0.0061602546,-0.016530849,0.02529079,0.030537153,0.048169915,0.016354851,0.006633296,-0.06287416,-0.0070703593,-0.010990628,0.067252494,-0.0066810814,-0.017026355,0.03908221,0.0041082706,0.07659865,0.025756689,-0.033141594,-0.021224549,0.074444965,-0.004640539,-0.041843347,-0.0021369075,-0.03249848,0.0043520746,-0.06556783,0.010961146,-0.00015078214,-0.038196106,-0.03317988,-0.0041601504,0.011018931,-0.045249976,-0.07392484,0.05108436,-0.05059428,-2.4112618e-33,0.057060424,-0.040016968,0.059396118,-0.031540003,-0.10645013,0.03815158,-0.014913252,-0.044388376,0.0622679,-0.020262558,0.030376686,-0.0426664,-0.017971147,-0.036684435,-0.0047020447,-0.030157622,0.010341972,0.030871294,-0.049234483,-0.033787176,-0.0006909362,0.08659663,0.03294156,-0.044666354,0.04717256,0.005130903,0.019004552,0.08976421,0.072028905,0.085807,-0.03738389,-0.009862605,-0.059534688,-0.0996999,-0.03768867,0.17140509,-0.024730777,-0.035080332,-0.024396438,-0.01412174,-0.016021995,0.024434842,0.0028710726,0.092079066,-0.005970212,0.010224065,-0.05539171,0.051115528,0.02231071,-0.09463845,0.010507846,0.030394597,0.065509364,-0.04036429,0.01569601,-0.014844843,0.04457506,-0.05554296,0.022100879,-0.06301689,-0.004751187,-0.055285927,0.026218304,-0.024378926,-0.028859789,0.0821175,-0.01551197,0.028759424,0.03772219,-0.019989468,0.069193356,0.0037212602,0.052966192,0.033353943,-0.009724103,0.057883084,-0.0057095294,-0.021700718,0.04246077,-0.016456142,-0.04186379,0.027371272,0.023233991,-0.06308729,-0.10555806,-0.118124425,-0.029263215,0.038830318,0.026718007,-0.029171014,-0.042664953,0.03936619,-0.03737214,0.024285385,-0.07448168,-2.651788e-08,0.056716215,-0.08105448,0.07735408,-0.06720558,0.073255345,0.04696941,-0.11564863,-0.0647342,0.03898221,0.03189355,-0.011943272,0.018453784,-0.0362386,-0.01020976,-0.022452673,0.017112892,-0.035771407,-0.055850834,-0.039746776,-0.05203413,-0.07217663,-0.01843173,-0.11863848,0.006633404,0.0875451,-0.06885826,-0.051586445,0.008081436,-0.054973885,-0.013899472,0.0033448783,0.040805012,0.011392358,-0.021200018,-0.11768379,0.038656324,-0.07219453,-0.021115363,0.023588372,-0.07394903,0.028809693,-0.06345373,0.051035434,-0.013184821,-0.0876133,0.02761346,0.026514797,-0.034639716,-0.018319305,-0.010219855,0.05102993,-0.008686051,-0.010657923,0.008158992,-0.06144719,0.025753217,0.03255991,-0.042662546,-0.01296423,-0.11601599,-0.051759195,0.021663696,0.08163379,-0.042331845 +2.4.1.277,"DesVII is the glycosyltransferase responsible for the attachment of dTDP-D-desosamine to 10-deoxymethynolide or narbonolide during the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in the bacterium Streptomyces venezuelae. Activity requires an additional protein partner, DesVIII.",384,1.0,-0.09233511,0.010805241,-0.10153605,-0.09857416,-0.037824005,-0.07032017,-0.047352582,0.065786324,0.03756241,0.021296035,0.006389735,-0.0021688698,0.04822884,0.030727856,-0.04240114,-0.03197861,-0.041214146,0.04689665,0.0032130284,0.027116675,0.10511878,0.09902901,-0.0124881,-0.010251231,0.026166992,-0.004014344,-0.0121163735,0.006057044,-0.034598473,-0.053204153,0.053895365,0.013429383,0.003208568,-0.04123066,0.05074497,0.072531566,-0.047913425,-0.032767437,0.16294296,-0.02587128,0.022015117,-0.012303506,0.033098403,-0.0037143708,0.011942466,-0.077383384,-0.144801,0.117340416,0.06248173,-0.060523175,-0.0054963,-0.02653679,-0.012469471,0.0511623,0.05921252,0.03399408,-0.010490381,-0.02631007,-0.0039943075,-0.03692483,0.07395361,-0.0052920147,0.020018881,0.011402091,-0.0568503,-0.025475224,0.09177293,-0.06047318,0.06354786,0.061960883,-0.027494079,-0.029207924,-0.026825389,0.043415044,-0.0025941548,0.046067547,-0.030134724,0.016893582,-0.059850726,-0.04342146,0.117288426,0.07249519,0.11316536,0.0785282,0.046193324,0.003637142,0.03635653,-0.030873572,0.08631543,0.038555905,-0.027092393,-0.002950735,-0.019938763,0.012117979,-0.07986823,-0.06453255,0.014456102,0.030963516,-0.009551903,0.016096814,-0.039102796,-0.008231065,-0.00049068447,0.012064489,-0.03161115,0.002541459,0.038416687,-0.040137447,-0.01550796,-0.02449723,-0.0115620345,0.020514963,-0.01055867,0.025645642,-0.048962254,0.07102162,0.07161744,-0.03187659,-0.026440494,-0.07815318,0.01535089,0.015145051,-0.047482353,-0.0112504875,-0.022730278,0.0011028636,-0.08891032,3.6073574e-33,0.037074395,-0.0074448353,-0.017300671,0.023278765,0.025061477,-0.018058624,-0.12808275,0.010609082,-0.046160296,-0.08913077,-0.1307301,-0.03164834,0.00675905,0.120813325,-0.0055828434,0.013775777,0.062477138,0.058379933,0.026614156,-0.055070378,0.037443012,0.025988087,-0.046144407,-0.026250416,0.025881937,0.09694884,-0.044573158,0.020429129,0.06951827,-0.0278725,-0.018496351,-0.14546458,0.027956136,0.018087896,0.107509084,0.05685624,-0.078487605,-0.04942383,0.06141064,0.037780557,-0.05583123,-0.002570673,-0.046446335,-0.020223731,-0.013662345,-0.026341198,-0.017897133,-0.01745719,-0.011217693,0.041009594,0.03868753,0.006410062,0.0067803855,-0.06853422,-0.10495342,0.0050263805,0.07424311,-0.020976549,0.023641247,0.062229116,-0.01747062,-0.014235408,-0.00934376,-0.0057900497,0.07660087,0.008382033,-0.040234134,-0.012721424,0.06445287,0.001715676,-0.11196898,-0.007142081,0.06655272,0.022719456,0.07046072,0.0353948,-0.015361561,0.016590938,0.044010434,0.04399155,-0.02946503,-0.017429573,-0.0869564,-0.10905264,-0.0026920598,0.08041044,-0.036452755,-0.06883371,0.01134054,0.046675112,-0.04162006,-0.0593971,-0.050813608,-0.049514364,0.04616014,-5.9969912e-33,0.026579266,-0.018038845,0.0665761,-0.010075498,-0.041561555,0.086956605,-0.07672456,-0.0066688587,0.024535356,-0.031182693,0.04398884,-0.0065741744,-0.01483653,-0.027923787,0.002926301,0.04878223,-0.0166972,0.03469211,-0.0996751,-0.023699138,0.06266323,0.10893757,0.017392404,-0.060909588,-0.00953386,-0.03189398,0.07672717,0.036936603,-0.02362293,0.02360815,-0.003984925,-0.021750715,-0.08674261,-0.0042838873,-0.045158923,0.08663355,-0.09212771,0.0039154417,-0.0023059573,-0.040548455,0.0038175937,0.031847127,0.03234223,0.0769888,0.039367612,0.052977383,-0.031890485,0.022460002,0.025863186,0.022879092,0.06568629,0.04781019,-0.004942411,0.0045241374,-0.0027479264,-0.020362975,0.06183738,0.0005693964,-0.06095624,0.024010792,-0.017315485,-0.0204058,-0.020699723,0.012194452,0.005163478,0.056664187,-0.028998928,0.06491202,0.07695867,-0.031827364,0.06145806,0.024705637,-0.051655777,-0.02282084,-0.08076746,-0.05073839,-0.15655595,-0.04971585,0.027015615,0.022060975,-0.04400771,-0.016572766,0.0022189475,-0.023518039,0.0023729978,-0.02979784,-0.017840812,-0.008835559,0.013141881,0.05155869,-0.037835985,0.009634217,-0.046539534,0.040075842,0.012106116,-3.8225895e-08,0.06611936,0.027543193,-0.03321598,-0.010189973,0.026663354,-0.068448104,-0.04976601,0.0005232529,0.030605886,-0.0024249468,0.033550963,0.042481005,-0.041603524,-0.0516906,0.0016568184,0.06906036,-0.03253442,0.031915992,-0.017840771,-0.01198636,0.029111922,0.0036531305,-0.067132086,0.101542346,0.04860624,-0.05786983,0.069782756,0.043853786,0.015407196,-0.043544877,0.057682905,0.05996399,-0.095452495,-0.020865003,-0.03454345,-0.066203214,-0.048703182,-0.034999236,0.05419642,0.014517433,0.03471251,-0.012785044,-0.05257794,0.057116423,-0.10538298,0.07286018,0.008659506,-0.0026936706,-0.066370465,-0.019838728,0.003004264,0.013687488,0.0129745295,0.029710962,-0.18041718,0.030913465,-0.01198775,-0.007002268,-0.05789286,-0.02320292,-0.057716317,-0.012809377,0.17797673,-0.056441054 +2.5.1.97,"The enzyme requires a divalent metal ion, the highest activity values are observed in the presence of Mn2+ and Co2+ (10 mM). ",384,1.0,0.0029538674,-0.10857745,-0.066975944,0.01335299,0.045270544,-0.013241807,-0.0042817863,0.10247734,-0.0380824,0.00018586103,0.014932053,-0.03454973,-0.0062713167,0.09116293,-0.008014232,0.016780851,0.011451539,-0.04995616,-0.05055893,0.010855364,0.10148351,-0.027365964,0.003300247,-0.027851144,0.025946347,0.055696934,0.03065361,-0.065534115,-0.0014606039,-0.010392372,-0.026262978,-0.00121198,0.10898933,-0.035161234,0.04155243,0.07818925,-0.072248995,-0.044709727,-0.036565028,-0.0023181203,0.0318708,0.007243478,0.07985027,-0.0748697,-0.02947867,-0.072366916,0.0637334,-0.07444415,-0.0018542227,0.10589895,-0.049121574,-0.06561634,-0.0031550243,0.02958383,-0.022516692,-0.015061247,-0.07941575,-0.01619934,-0.03169425,-0.014228343,0.028982067,-0.005638029,0.006270351,0.018949326,0.0903141,-0.04100185,0.027777737,-0.054558884,-0.019444963,-0.005852783,0.033646904,-0.047171474,-0.058135524,-0.068757124,-0.006188857,-0.037070576,0.04494662,-0.07775143,0.08510913,-0.0020020287,-4.374598e-05,0.0033201098,0.04028198,0.061140828,0.03699104,0.117265925,0.03228073,0.046684716,0.013730784,0.08456149,0.01421681,0.060123228,-0.06900735,0.018284371,-0.02390704,0.057740845,-0.015384381,0.062207967,-0.01198285,0.009143646,0.034723155,0.06158762,-0.064124145,-0.004483926,0.00022017662,-0.016502779,0.07203023,0.06202288,0.004452066,0.0926915,0.079843916,0.037316192,0.042720385,0.021122608,0.057544816,0.1104676,0.058060687,-0.054744575,-0.09169612,0.025136111,0.058863364,-0.040962588,-0.00093457365,0.03829779,-0.035069056,0.10715001,-0.038572986,-1.780574e-33,0.033805545,0.01816626,0.05662489,-0.05312527,-0.033776112,0.012243367,-0.08065051,0.02008358,-0.010952683,-0.040510364,-0.09062603,-0.024410604,0.043908253,0.037021913,-0.028327681,-0.060746193,0.04810491,-0.011884325,0.096537635,0.0020036746,0.029790126,-0.035040136,-0.04813894,0.061318636,0.017797342,0.063532606,0.0446665,0.023187868,-0.021519825,-0.027623117,0.05221529,-0.14185247,-0.05660469,0.01164215,0.07650285,0.021209044,-0.023447031,0.046411432,-0.017085845,-0.027198281,-0.0032828536,0.035620123,-0.040166374,0.036374383,0.0616166,-0.1083074,-0.057127543,0.107840545,0.009296966,0.0321779,0.009638816,0.01639536,0.07254341,-0.03846854,-0.053101312,0.08743091,0.023195919,0.04423144,0.024394201,0.053851634,-0.018063497,0.00343246,0.030460488,0.12028477,0.02482792,0.05611888,-0.08096791,-0.053328816,0.04017119,0.083601505,-0.05380919,-0.06080818,0.055350732,-0.031072594,0.03217126,0.01498761,-0.01327083,-0.014710492,0.061555784,0.016470391,-0.03156233,-0.049266372,0.016230533,-0.04414568,-0.12368586,-0.0335936,-0.054682996,-0.05307534,-0.03488445,0.051299874,0.09062794,0.010077182,-0.057068493,-0.015983302,-0.019528653,-1.7242206e-35,0.07060697,-0.035096653,0.021828033,-0.070519276,-0.06330167,0.060532235,-0.0012925094,-0.08458628,0.048598234,0.020378523,0.08234645,-0.014525129,-0.035300206,-0.050806776,0.015675496,0.059604086,-0.049431074,0.09449394,0.107450455,0.012201164,-0.06992216,0.10796985,-0.007951358,0.06068061,0.036701687,0.030467646,-0.024122367,-0.0147002125,0.06374441,-0.023607988,-0.043026593,-0.05322547,-0.010249247,-0.016678315,-0.044638436,0.061110258,0.0027621135,-0.08307967,0.019393902,0.0454283,0.009842356,0.013164481,-0.02348081,0.10948215,-0.0077746357,0.0062613897,-0.09398651,0.007057652,0.0008343197,-0.07366705,0.030880658,-0.04114672,-0.04187402,-0.017061185,0.037320618,0.04646394,0.010215641,0.018671691,-0.012712605,-0.04003854,0.0068806056,-0.027248083,-0.039821133,-0.0022047411,-0.03952444,0.036421996,-0.021225737,0.043884005,-0.0239725,-0.03687578,0.02522275,0.07641907,0.08261277,-0.022403572,-0.08281115,-0.07083641,-0.03988432,-0.04234601,0.022228168,-0.09096612,-0.0121527165,0.07502911,0.00043701078,-0.092964895,0.014114222,-0.07045575,-0.0071345405,0.093654215,-0.005653088,0.016894173,-0.038543385,-0.06518087,-0.088046566,-0.0155978035,0.026084969,-3.0012753e-08,-0.025061145,-0.05330012,0.019106735,-0.10714951,0.031482782,0.06456255,0.021135176,-0.043247662,0.07629789,0.021899985,0.0063323625,0.022611437,-0.052263886,-0.002038882,0.06455326,-0.044189736,-0.02696883,0.020831037,-0.065727316,-0.038816206,-0.05230515,-0.005869682,-0.09902706,0.008448847,0.008897649,-0.044677433,-0.027643625,0.09199814,-0.06029839,0.008443136,-0.032873746,0.011468951,0.001520283,-0.04021352,-0.08731207,0.048812896,-0.019866707,-0.011410137,-0.065889694,0.03279064,-0.10285638,-0.06495877,-0.042119067,0.0039017051,-0.0681082,-0.006515387,-0.025450086,0.04081829,0.047894828,-0.016052686,0.02647494,-0.060661167,-0.04257263,-0.049472496,-0.069681145,0.055569645,-0.00016545375,-0.052845668,-0.073017426,-0.057862684,0.10710845,0.017826924,0.05499956,-0.080634505 +2.6.1.88,"The enzyme is most active with L-methionine. It participates in the L-methionine salvage pathway from S-methyl-5'-thioadenosine, a by-product of polyamine biosynthesis. The enzyme from the bacterium Klebsiella pneumoniae can use several different amino acids as amino donor, with aromatic amino acids being the most effective [1]. The enzyme from the plant Arabidopsis thaliana is also a part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates [3].",384,1.0,-0.05235271,-0.07789936,-0.08053086,-0.041777235,0.061115917,0.11131376,-0.119533956,0.08367851,0.07957007,0.02413913,0.025145307,-0.011471338,-0.015473864,-0.015061726,-0.02004087,0.08088741,-0.071508504,-0.014529235,-0.035356384,-0.06915251,0.08249708,0.08214973,-0.080015175,-0.051078252,0.10586014,-0.038272157,-0.0038517625,-0.03157904,-0.021128347,-0.019343019,-0.04657473,-0.019650396,0.04808663,-0.0045224684,0.026033148,0.110939324,-0.04890506,-0.049055513,0.11878007,0.010549458,0.043246236,-0.020814702,0.027685793,-0.08514271,-0.06850977,-0.017976241,-0.020541247,0.04703924,0.010405598,-0.051558252,-0.056405574,-0.06686426,0.0024614797,0.053500257,-0.00026468112,0.0389072,-0.018395957,0.01472906,-0.019349717,0.039466444,0.019662434,-0.004445292,-0.008608062,-0.008742806,-0.0065055573,-0.09580962,-0.010037741,-0.05373958,0.09717172,-0.033758536,-0.008431008,-0.040124457,0.00084902,0.018597413,-0.022957675,-0.014288816,-0.02997846,0.042200156,0.039130133,-0.07414777,0.060734622,0.009203537,0.0094649,0.053159505,0.04885373,0.025099002,-0.05440514,0.04705248,0.09413587,-0.052498713,0.020337645,-0.011982761,-0.0672558,-0.08846008,-0.08718596,0.009763516,0.007877691,-0.005780865,-0.073823154,0.022296835,0.02968074,0.040603265,-0.069391295,-0.1010634,-0.09755464,-0.001113914,0.06373435,0.04307973,-0.010151435,-0.045517795,0.039805304,0.002622246,0.024365833,0.03095803,-0.04073317,0.05955779,0.0704371,-0.083541304,-0.07515655,-0.021577617,0.0124830045,-0.04915944,0.09269766,0.028880784,-0.061070397,0.019416237,-0.07339927,3.4262744e-33,0.06672339,0.042435445,0.002896234,-0.0640464,0.047544185,-0.058701683,-0.056134507,0.02088261,-0.015734648,-0.09382653,-0.09156656,-0.06348103,0.010128538,-0.005043267,-0.06320549,0.016409043,-0.028229835,-0.024109518,0.075317636,0.030381447,0.02580442,-0.03953034,-0.037780385,0.076102555,-0.015167299,0.012510491,0.059502825,0.014440433,-0.0017813399,-0.00033103855,-0.06248196,-0.004720321,-0.066876516,0.021562822,0.022047685,0.026912788,-0.10780025,-0.037733167,0.014207168,0.070415795,0.020246906,0.017905196,0.010563706,-0.012864631,0.041879788,0.052298114,-0.06660862,0.04358834,0.00855053,0.0723202,0.071437545,-0.031625334,0.13955872,-0.04327943,-0.10608789,0.02303665,0.012106736,-0.049061883,0.02604062,0.09047681,-0.01639501,-0.031621646,-0.008793677,0.05975861,-0.024487788,0.017778236,-0.06679692,-0.046488825,0.012715431,0.118545935,-0.007857407,-0.066491775,0.037135296,0.051755406,0.027768988,-0.038525093,-0.07579024,0.03472308,0.03437425,0.022995586,0.084554985,-0.024355188,-0.008523047,-0.0030007982,-0.052019008,-0.040008884,0.006892747,-0.062320225,-0.002973528,0.008534866,0.0157461,-0.08079042,0.0032035245,0.04084731,0.029330725,-3.5895953e-33,0.089598835,-0.0579477,0.06729138,-0.068658575,-0.031548142,0.060610756,-0.0049087517,-0.054777257,0.02003743,-0.0130155515,0.10680315,-0.007860972,-0.0046388414,-0.0016995855,0.06147806,0.006028711,0.041364774,0.065947555,0.0049580233,0.0018997288,0.042139944,0.015754702,-0.008258376,-0.057053555,0.085528344,-0.021699421,-0.010852699,0.10307946,-0.010121074,0.009041017,-9.030035e-05,-0.010173652,-0.056092985,-0.03673154,-0.027257051,0.0879533,-0.034983996,-0.030151617,0.055858243,-0.0036598449,0.04615626,0.068485826,0.045324296,0.07850594,0.037587114,-0.0039899545,-0.08552563,-0.06207085,-0.07590144,-0.084878065,0.043736145,-0.039640114,-0.007927107,-0.011979091,-0.033649992,0.09873476,0.01152646,0.03094388,-0.061499685,-0.06400908,-0.07904192,-0.07264005,-0.018100616,0.05800094,0.03134865,-0.004302848,0.030296454,0.08330531,-0.0106727965,0.028232632,0.028361097,0.026172578,0.08764931,0.12952325,-0.056379166,-0.056943577,-0.06981095,-0.0030452632,-0.015009516,-0.035944942,-0.030169677,-0.048437525,-0.022122195,-0.06455844,-0.010439527,-0.08251113,0.058921713,0.10418423,0.062191818,0.07419627,-0.06776277,0.024510568,-0.026977094,0.056828987,0.075876504,-4.4388116e-08,0.03866986,-0.07708564,-0.0047654496,0.013486764,0.03147057,0.023328152,-0.0042732186,0.0077439463,0.05741046,-0.029746868,-0.050241224,0.062026687,0.00044845464,0.030867966,-0.015847541,0.03944512,-0.02912799,0.033310827,-0.01242449,0.0554171,-0.023187686,0.016376873,-0.079520784,0.0151902605,0.020364214,-0.051674508,-0.03739492,0.074241206,-0.010106836,-0.025243914,-0.0008997775,0.022773294,-0.014421713,-0.034302153,-0.0823433,0.02971976,-0.059716046,-0.06720094,0.0077129076,-0.014633263,0.041183565,0.03985295,-0.052822217,0.045380678,0.02143162,-0.04035385,-0.016455496,0.004335295,0.004592107,0.049704302,0.017016388,-0.018543107,0.025490334,-0.07196909,-0.06076562,-0.04662956,-0.010791078,-0.0057852,-0.008678057,-0.042443093,-0.032484595,0.025091758,0.1899923,-0.0135388775 +2.6.1.89,A pyridoxal-phosphate protein. The reaction occurs in the reverse direction. The enzyme is involved in biosynthesis of D-mycaminose. ,384,1.0,-0.07431488,-0.0664386,-0.028564326,-0.05059714,0.03424434,-0.06195325,0.081173316,0.06890087,0.061449625,0.108102016,0.03174509,0.004866909,-0.098821,0.065163754,-0.027715176,0.05545231,-0.045488194,0.020731784,-0.027272735,0.0054524634,0.09375001,0.05573209,-0.00072073715,-0.00087559497,0.043037087,0.04341497,0.07667253,0.09161137,0.0021842995,-0.054802313,-0.057581913,-0.024824642,0.010635271,-0.03319908,0.036890566,0.075123645,-0.04348399,-0.033333443,0.025224477,0.035118442,0.0487722,-0.030020999,0.021073248,0.019073611,-0.041651964,0.07218717,-0.028547993,0.10826579,0.04472748,-0.010620472,-0.09953185,-0.036680523,-0.054230936,-0.04037645,-0.01904137,0.060703766,0.046636213,0.018048396,-0.021069953,-0.022489706,0.04863442,-0.04076306,-0.008977944,0.031504817,0.054005835,-0.037036363,-0.005037391,-0.0027263104,0.035409298,-0.020013379,-0.01956291,-0.051092196,-0.030118646,0.048610646,0.0100576915,0.010604821,-0.015046425,-0.033533562,-0.02017576,-0.014374865,0.048876833,0.029805666,0.019867554,0.04787444,0.016454194,0.016230462,0.0819305,-0.011803646,0.07755954,-0.001214739,-0.091260076,-0.06313667,-0.047659587,-0.011377035,-0.05612212,-0.005613958,0.09320381,-0.0042943703,0.015811155,-0.041072156,0.017072137,0.016025078,-0.05080862,-0.046073016,-0.044077728,0.038126037,-0.10326902,0.029041735,0.0057238927,-0.037153594,-0.027716057,0.053151093,0.05334307,0.041103505,0.013720002,0.06606287,0.04719989,-0.04551795,-0.05870441,0.021391185,0.034509126,-0.049772352,-0.02340308,0.06321972,-0.12259326,0.030896017,-0.075929314,-1.2529663e-33,0.026674414,0.021693733,0.028679447,0.023182077,0.012486788,-0.048820425,-0.10109321,-0.040704977,-0.12197957,-0.03419794,-0.034974568,-0.11950754,0.047595292,0.05329795,-0.11356043,0.011689798,-0.025767135,0.010085704,0.057695813,-0.015395439,0.02264818,0.10571058,-0.0669533,0.035844535,-0.02693733,0.10797179,-0.012625821,0.008821288,0.044101637,-0.011109408,0.025934227,-0.059747837,-0.093668506,-0.04269041,0.045317754,-0.061008383,-0.026558671,-0.098570585,0.017342275,0.020687765,-0.071241446,-0.04672939,-0.0450756,-0.040107045,0.07865392,-0.09167799,-0.011187498,0.05535662,-0.010368566,0.0400945,0.043535586,-0.03685619,0.09335489,-0.061200164,-0.11951094,-0.05593495,-0.033817664,-0.032954685,0.01388503,0.05124268,-0.0009499049,0.015778953,-0.04784902,0.073674336,-0.050524898,-0.06661501,-0.0045250603,-0.04332813,0.042269506,0.0655024,-0.008544211,-0.026305238,0.064254396,-0.06439238,0.014992091,0.0019257468,-0.08872511,0.031598873,-0.04601284,0.023463253,-0.049158983,0.05527733,-0.07161574,-0.040340167,-0.010544813,-0.042852383,0.003282424,-0.103253625,-0.0717431,0.03145857,-0.014506258,-0.05436053,-0.033034924,0.0204113,0.036680598,-1.3715812e-33,0.046056982,-0.026724227,0.041215178,-0.058263578,-0.06410746,-0.01254509,0.07434473,0.043045327,0.09327631,-0.03636769,-0.007852188,-0.07827565,-0.021094695,-0.015882406,-0.0027696781,0.07073042,-0.03698265,0.023658026,0.006912522,0.011962807,0.0038321535,0.08547893,0.033772126,0.051238243,0.08418917,0.029362861,0.02272284,0.08422261,0.03230627,0.01901911,0.0659428,-0.008136666,0.011766869,-0.060678896,-0.042221773,0.058731537,-0.083252765,-0.03471348,0.017144013,0.0046022325,-0.013382099,0.031152628,0.09641915,0.026024543,-0.031996112,0.028154077,-0.08013058,0.021916687,-0.016818255,-0.11475037,-0.005006746,0.03377515,0.021400386,0.032165326,0.05403812,0.037805047,0.050125584,0.08882546,0.01150625,0.03828228,0.01312969,-0.07102128,0.050194368,0.0062039536,0.025951905,0.086323634,-0.0014501238,0.016558565,0.044227563,-0.0024578718,0.14577834,0.10897902,0.003097321,0.054263677,-0.02049482,-0.050553977,-0.06649602,0.07513519,0.011563128,0.0100541,-0.06652433,-0.03563164,0.0065722973,-0.019573392,-0.057501584,-0.09664658,0.018929178,0.08969407,-0.028363345,0.00920509,0.020008268,-0.010112731,-0.039565496,0.03559789,0.08039562,-2.594791e-08,0.07820287,-0.12771976,0.043925177,-0.034808088,0.028883673,-0.0012358899,0.036667507,0.07124843,0.04281317,-0.020853886,0.010249297,0.023840304,0.0769981,-0.042488866,0.0910806,0.0621668,-0.03302366,-0.053714037,-0.014438831,-0.02165086,-0.037723962,-0.03897776,-0.09284534,0.025782378,0.00999743,-0.040161617,0.034386046,0.039703052,-0.010016102,-0.018973345,0.03003704,0.004715234,-0.027523108,-0.03993109,-0.07164663,0.07544448,-0.09674986,-0.032535095,0.052061185,-0.04878733,-0.010323714,-0.01794626,0.0018557153,0.03192051,-0.074151516,0.05248294,0.012401356,-0.011094703,-0.0077141766,-0.0034160307,-0.013132988,0.0042525614,-0.028730609,-0.034961216,-0.13279857,0.046872605,0.017758144,-0.03408766,-0.03718563,-0.051060222,0.028602105,0.026919859,0.0989405,-0.049872484 +2.6.1.90,"A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. The reaction occurs in the reverse direction. ",384,1.0,-0.04423322,-0.08068478,-0.05613071,-0.07619734,0.0137205,-0.012581845,0.028595084,-0.010318247,0.06278849,0.071291514,0.038059626,-0.003461426,-0.12665588,0.031038113,-0.01487785,0.026552802,-0.058496453,0.03435714,0.04645858,-0.010718429,0.1181813,0.02631365,0.04001427,-0.00078060717,0.07406209,0.058405835,0.099301815,-0.025138367,-0.011611906,-0.06497658,-0.062913455,-0.050785307,0.0125514325,-0.036675744,0.040114213,0.09180257,-0.08227432,-0.0017461678,0.026639737,-0.014067892,0.058987904,-0.032465998,-0.030970411,-0.0015130463,-0.05845935,-0.0020091967,-0.059882093,0.08053036,0.06331162,-0.021783084,-0.015676092,-0.015570932,-0.03319156,-0.05722644,0.0019980138,0.060287714,0.05285396,-0.011007751,-0.04976894,-0.010267089,0.046378665,0.012997321,-0.017258829,0.0103214625,0.08219112,-0.05502875,0.023159573,-0.027892957,-0.009677559,-0.050532293,-0.053654186,-0.06970362,0.05676361,-0.018720126,0.00033954426,0.023702702,-0.008719282,-0.004352205,0.039856322,-0.032090012,0.092691354,-0.0010613664,-0.0003285479,0.11481358,0.035548214,-0.023657389,0.0025319215,0.009029586,0.024471937,0.004048631,-0.03755041,-0.029479016,-0.024302157,0.03390002,-0.04075618,0.06297524,0.027953664,-0.030972958,0.029683974,-0.025147432,-0.031175377,0.052062854,0.0058868686,-0.054470632,-0.059092388,0.014973725,-0.08410619,0.02590331,0.015565083,0.017161425,-0.036350895,0.028989488,0.03787841,0.06434595,-0.047628142,0.050202332,-0.01905648,-0.05962397,-0.009152842,-0.03301637,0.031751063,-0.024999326,-0.017959742,0.12072162,0.00010358196,0.014010283,-0.040635746,-1.8433821e-33,0.12445125,0.09728255,-0.025022455,0.00499146,0.026773466,0.0039547877,-0.077595346,-0.053300787,-0.07628073,0.05001075,-0.07238998,-0.104866624,0.02895212,0.029164048,-0.059528355,-0.021368628,-0.065420955,0.07057605,0.08048626,-0.019470122,-0.0045266477,0.117039606,-0.07093821,0.03419154,-0.019811662,0.091753304,-0.067297496,0.05071749,0.06642573,0.015378814,0.012744671,-0.10183886,-0.07787326,0.008382995,0.04211276,-0.03263338,-0.07458957,-0.08079066,-0.051111903,0.017023686,-0.00050895324,-0.042719986,-0.037870817,-0.009015896,-0.01786783,-0.07598446,0.0123170735,0.0397941,0.021528898,0.0629219,0.046010047,-0.069296815,0.125082,-0.021552179,-0.06503084,-0.013498321,-0.11844822,-0.012053945,0.05105936,0.054926574,0.038208887,-0.01672151,-0.03293887,0.053928312,0.0019728604,-0.027288496,0.025215995,-0.04690974,0.045568645,0.053399295,-0.025737654,-0.04922324,0.04503859,0.011833776,-0.008450762,-0.0072571402,-0.026966369,0.053003132,-0.018893713,0.0023684003,-0.03950748,-0.018877607,-0.01996085,-0.03664032,-0.01896348,0.021500789,-0.019231427,-0.074211165,-0.018666934,0.014278129,-0.0052914917,-0.06283335,-0.04865223,0.10171642,0.053750448,-8.296729e-34,0.06375806,-0.09074161,0.061388034,-0.091576904,-0.058903854,0.03940419,0.046501625,0.01373943,0.07307055,-0.0131913815,0.035071842,-0.053748835,-0.033546444,-0.09519171,-0.005063688,0.051282674,0.020979537,0.048572615,-0.023504796,0.029308315,0.051438298,0.052092087,-0.016614806,0.08747381,0.06175914,0.042998582,0.052010354,0.027630595,-0.04321304,0.02752276,0.041551016,0.031739555,0.015431258,-0.017774135,-0.051403053,0.037428025,-0.057177976,0.014260261,-0.02606886,0.054529447,0.009589326,0.066120364,0.06870786,0.007884574,0.048920248,0.07236356,-0.054336034,0.0068416945,0.04514801,-0.0391383,0.0356787,-0.014266859,0.05267559,0.012278412,0.027702885,0.03879761,0.020929763,0.032844577,0.01272383,0.027515836,-0.011645316,-0.06852062,0.05652258,0.03696999,0.04512835,0.06775143,-0.045136943,0.0053037037,0.035122737,0.040357262,0.043032467,0.042450737,-0.025298083,0.08161646,-0.011607531,-0.07592406,-0.12074097,0.009238841,0.03355879,-0.028374337,0.019734263,0.034834962,-0.00087570155,-0.00714743,-0.092164926,-0.074280106,0.041609522,0.1125311,-0.014844368,0.039334077,-0.057761908,0.0028576232,-0.05462706,0.043509096,0.09929324,-3.7213773e-08,0.119117714,-0.063821994,0.019278597,-0.09055768,-0.019706821,0.0027036387,0.025816336,0.058246233,0.054350078,-0.09068245,-0.0378653,0.0797336,0.014273305,-1.550672e-05,0.037790652,0.013605905,-0.030349005,-0.0061554573,-0.048778746,-0.06355845,-0.02451258,0.00096200936,-0.07721039,0.031905685,0.053142697,-0.021385055,-0.0006571487,0.04805672,0.0022135123,-0.012236119,0.040014096,0.013925933,-0.047218047,-0.06015917,-0.08441094,0.08099569,-0.041161194,-0.10791895,0.0076469267,0.00972615,-0.04808851,-0.014746092,0.0015059195,-0.016099628,-0.078232326,0.033805013,-0.04858268,0.020807697,-0.03316738,0.015669193,-0.0036333036,-0.014044293,-0.112412855,-0.11530926,-0.14989921,-0.038247664,-0.013283271,-0.0593358,-0.016415248,-0.07771997,0.028460091,0.003840692,0.15313919,-0.07369391 +2.6.1.91,"A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-aspargine residues in Campylobacter species [1-3] and O-linked glycosylation of certain L-serine residues in Neisseria species [4].",384,1.0,-0.028246518,-0.059481446,-0.113510385,-0.03235626,0.010264984,0.0479298,-0.05252433,0.010024716,0.061606828,-0.06154715,0.048531823,0.0110796895,-0.058701348,0.07680706,-0.063949265,-0.029504314,-0.0058076093,0.020980526,-0.0062277564,0.0010493367,0.046919096,0.06604742,-0.0083245495,-0.05103448,0.044970516,-0.03588657,0.053432453,-0.030998265,0.0010519142,-0.0590074,-0.021803893,-0.052816715,-0.018316459,-0.08215405,0.115147494,0.04052851,-0.029974384,0.0035044458,0.09953805,0.022432115,0.061611783,-0.014269529,0.0003505275,-0.013495104,-0.05054368,0.015932431,0.010033763,0.10366757,0.0918483,-0.06922841,-0.05343952,-0.005989886,-0.05374028,-0.009560525,0.006432821,0.011146254,-0.020067962,-0.03941465,-0.043806426,0.035111632,0.028117973,0.039833862,0.06321795,-0.022974294,0.027007397,-0.070167415,0.045344673,-0.052725803,-0.027631907,0.05123543,-0.0937728,-0.05879796,0.06286031,-0.002528496,7.9770696e-05,0.07069657,-0.052114606,0.05943433,0.038252816,-0.060113255,0.043716643,-0.017117009,0.039455608,0.09521852,-0.020955587,-0.061219085,0.018437643,0.049230393,0.09528051,0.01851504,-0.039492976,-0.021118524,-0.0032433788,-0.018410956,-0.07633994,-0.033743896,0.02352796,0.051269643,-0.0375967,-0.067591116,-0.04277821,0.018743506,0.021206735,-0.07673474,-0.10438777,-0.0016063296,-0.0045724954,0.059069622,0.047212984,-0.019345889,-0.07936162,0.105165586,0.0011317373,-0.021275412,-0.054564416,-0.019149706,0.042907286,-0.090364344,-0.102991946,0.0047932905,0.029673547,-0.052584097,0.04523503,0.07853318,-0.024484178,0.059033155,-0.039740734,3.412727e-33,0.07823052,0.059623796,0.046823185,-0.025117004,0.06940192,-0.051599905,-0.0749992,-0.06621921,-0.07225997,-0.03703048,-0.008611513,-0.08251318,0.02093816,0.060500354,-0.040841665,0.043420784,-0.050955772,0.004305174,0.05848296,-0.0055666603,0.040911775,0.07764322,0.019827116,0.03657441,0.047391754,0.08200002,-0.049273442,0.014858711,-0.020216506,-0.016377633,0.037600297,-0.13883099,-0.1234065,-0.0138540175,0.103900544,-0.06271902,-0.016252082,-0.09659176,0.008602382,0.0022288158,-0.036127064,0.05182555,-0.0030202474,0.0025707404,-0.026569307,-0.0029013574,-0.05042188,0.05721193,-0.014596584,0.050001655,0.05389432,-0.07705306,0.08182831,-0.0005061857,-0.06743138,-0.00034266963,-0.04460116,0.0033862027,0.021160258,0.07208147,0.06889061,-0.00039921037,-0.028705055,-0.06611348,0.029881628,-0.024694223,0.020757455,0.03852339,0.09386469,0.010918976,-0.023581315,-0.015755018,0.09577682,0.08017575,-0.042985007,-0.058159646,-0.030627646,0.003002152,0.056271717,0.016354475,-0.0323168,-0.016575597,-0.019900622,-0.07554018,-0.024027897,0.00015854074,-0.0076649105,-0.07391596,-0.010560528,0.009752291,0.024251105,-0.00531829,-0.029051604,-0.0077428445,0.0060680946,-5.2848327e-33,0.0805686,-0.07731298,0.034889843,-0.023573915,-0.06266686,-0.039307,0.008350526,-0.007859445,0.008093061,-0.048220646,0.010133354,-0.022298552,0.08018038,-0.033423062,0.012763295,0.0024760168,-0.0021642456,0.09191319,0.020594899,-0.02231698,0.031124631,0.017102588,-0.01923758,-0.008001794,0.056302644,0.041129306,-0.021318736,0.09026063,-0.061891526,0.024530558,0.07639303,0.10407784,-0.0515208,-0.1213813,-0.030808084,0.010004771,-0.013823702,-0.01504831,0.033081416,-0.059630975,0.06366545,0.093038924,0.01768839,0.007405556,0.030255372,0.043676183,-0.08274108,-0.022180451,-0.0052840556,-0.07366598,0.009501457,0.0013875106,0.0047510285,0.017973112,-0.015651895,0.08451776,0.042954817,0.04568805,0.05481746,0.011448913,-0.026295096,-0.06374725,-0.0069899424,0.03267688,0.03122272,0.052317422,0.0076475013,0.0009369398,0.094527476,0.004837678,-0.010341177,0.0135920225,0.02455,0.10122904,-0.073447,0.0042795558,-0.05238037,0.007841581,0.02385517,0.00837301,-0.04623074,-0.05686473,-0.057592828,-0.05191102,0.004001677,-0.04609696,0.07268069,0.12820005,0.016686557,0.019047892,-0.0098392535,-0.079450816,-0.021195384,0.06731891,0.026198728,-4.1573923e-08,0.08030164,-0.08205619,0.039621305,-0.08123108,0.028227748,0.024436196,-0.04892414,-0.023527348,0.05040604,0.0036409365,0.047375012,-0.014552039,-0.021317165,-0.051575255,0.013944161,0.08657665,-0.010802402,0.031295672,-0.011252969,0.028758269,-0.06579776,0.050913144,-0.13050464,0.05937541,0.07479073,-0.05206933,-0.0057688677,0.019891407,0.012456048,-0.042566177,0.0061258194,0.03959059,0.0042891447,-0.05862305,-0.059725374,-0.0012105195,-0.054822545,-0.059346363,0.05253517,0.013078938,-0.0061756824,0.005584475,-0.03337077,-0.03001727,-0.004720865,0.103807434,-0.040359467,-0.015024007,-0.11449128,0.006962369,0.04505999,-0.018160079,-0.031913903,-0.06352198,-0.14992145,0.050600685,0.0001940355,-0.027280511,0.0033716704,-0.052510627,-0.09710439,8.5954634e-05,0.12453056,-0.06835121 +2.6.1.92,"A pyridoxal 5'-phosphate protein. The enzyme transfers the primary amino group of L-glutamate to C-4'' of UDP-4-dehydro sugars, forming a C-N bond in a stereo configuration opposite to that of UDP. The enzyme from the bacterium Bacillus cereus has been shown to act on UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose, UDP-beta-L-threo-pentapyranos-4-ulose, UDP-4-dehydro-6-deoxy-D-glucose, and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose. cf. EC 2.6.1.34, UDP-N-acetylbacillosamine transaminase, which catalyses a similar reaction, but forms the C-N bond in the same stereo configuration as that of UDP.",384,1.0,-0.0782049,-0.098666936,-0.071510054,-0.08767881,0.006147183,0.055924285,-0.030748615,0.06285203,0.027326941,0.021145605,0.040919952,-0.061140478,-0.027715307,0.08135162,-0.025155272,-0.0023350026,-0.036593508,-0.03789501,0.014374783,0.002456326,0.09255174,0.051519662,-0.046662785,-0.05334616,0.06839652,0.07555903,0.14277172,-0.05346229,-0.0288194,-0.094821505,0.023162978,-0.07526233,0.012217786,-0.032507382,0.07670001,0.07905596,-0.051851112,-0.05557498,0.13060527,-0.08110887,0.0042421026,0.028647892,0.0033358776,-0.008260964,-0.025326261,0.0070931646,0.0018078908,0.06678073,0.016534615,-0.06354187,0.012085812,-0.0071962685,-0.001433683,0.037858557,0.0012585154,0.018192118,-0.056932982,-0.010433685,0.0023766463,0.0144522125,0.02656687,0.010457459,0.085564576,-0.021629436,0.020655675,-0.02462687,0.07469993,-0.06443091,-0.015157381,-0.0042095413,-0.08941352,-0.037062824,0.07136596,0.021615837,0.057402868,0.017419081,0.0030746495,-0.0032876194,-0.01076115,-0.07776844,-0.007181703,0.032310933,0.023699442,0.0967142,0.004704074,-0.020252855,0.03412682,0.010146272,0.047642782,0.020479241,0.0030385917,0.040261295,-0.03387347,-0.04195783,-0.072925724,-0.015534776,-0.0017717844,0.070173375,0.027871478,-0.03545592,-0.0013731237,0.08039001,-0.06335105,-0.081886865,-0.0036217554,-0.03764632,-0.002713799,0.04617428,0.0065630656,-0.004013631,-0.010207818,0.035813928,0.030588586,-0.015263588,-0.091836594,0.03085468,-0.037584737,-0.06411881,-0.06294489,-0.034785815,0.033424024,-0.027094288,0.023917684,0.0627747,-0.013856658,0.030960113,-0.06072459,-1.4542452e-34,0.032010756,0.020660227,-0.019929182,-0.04278339,0.091080606,-0.06736379,-0.10116934,0.08000835,-0.0403712,0.016948177,-0.12047977,-0.04554992,0.08571564,0.039233662,-0.035289336,0.033526745,-0.00012036795,0.024469053,0.019323157,-0.034244597,-0.022038147,0.10806483,0.031737264,0.020242047,0.054139122,0.050354194,-0.003005699,0.05623525,0.043989163,-0.02182599,-0.03506073,-0.08485641,-0.051738862,-0.03237947,0.07574131,-0.021096615,-0.043131497,-0.04754361,-0.024368295,0.012276031,0.0024404607,0.056799408,-0.039126016,-0.0023184086,0.055605743,-0.0020464284,-0.049977675,0.009591835,-0.02546144,0.012432105,0.08962398,-0.061022814,0.11839334,-0.006262582,-0.008960091,0.030720182,-0.04844105,-0.02427817,0.021380056,0.053508304,0.02838252,0.040604208,-0.087545976,-0.030034259,-0.022196699,0.022662653,0.026931196,-0.0066452078,0.04050969,-0.029411353,-0.06314991,0.0024681175,0.08505421,0.062215596,-0.020220539,-0.020057693,-0.0386896,0.001657068,0.05201974,-0.00814019,-0.06923053,0.01346212,0.018630058,-0.082201704,-0.034949824,0.004045443,-0.021319734,-0.0886093,-0.002035873,0.036493793,-0.012428261,-0.07399117,-0.087472215,0.044725,0.017465372,-1.8422022e-33,0.08839268,-0.081973344,0.005315812,-0.065232106,-0.05141889,0.037561513,0.06337792,-0.07465453,0.035743088,-0.06197831,0.07615515,0.008816178,0.021346448,-0.004211063,0.042974416,0.055011813,-0.027358431,0.12374928,-0.04193052,-0.015832813,0.04557361,0.12432525,-0.011178425,0.022049226,0.059854493,0.04035043,0.037746836,0.11595403,0.06599421,0.039307613,0.060163718,0.011223792,-0.029200898,-0.074536055,-0.044045653,0.065891914,0.012586272,0.011483364,-0.013606727,0.043659516,0.025475984,0.07316523,-0.026266655,0.0019026152,0.044393145,0.07108594,-0.027602091,-0.029275248,-0.07547194,-0.031384654,0.07902268,-0.0012544283,-0.017304555,-0.02788872,-0.004591698,0.04641381,0.005487531,0.018455312,0.014586459,-0.021469213,-0.018702304,-0.13250476,0.0662425,-0.01431791,0.03298597,0.032447264,0.01184936,-0.007303781,0.03779384,-0.020552253,-0.014407796,-0.031224722,-0.043906286,0.057209183,-0.07459779,0.029200152,-0.088368565,-0.06274755,0.022963282,-0.025059154,-0.03845814,-0.034421127,0.00581181,-0.014775198,0.023514079,-0.0075387917,0.06383771,0.09444782,0.041185103,0.023591463,-0.018844336,0.00055321073,-0.004138441,0.057012636,0.1043652,-5.36167e-08,0.081587315,0.0025772832,0.04667757,-0.016525745,0.019332305,-0.009359302,-0.033135682,-0.02254529,0.07162095,-0.09240644,-0.05387957,0.101473615,-0.0889155,0.007594288,-0.02522035,0.028051453,-0.10820102,-0.05063251,-0.017606752,0.000829288,-0.0982869,0.0009946318,-0.1328079,0.0062513924,0.014854309,-0.12606232,0.01913969,0.0066113737,0.008962907,-0.020318093,0.011425621,0.020083006,0.03666514,-0.08788122,-0.030349417,-0.0061752885,-0.037092205,-0.06373538,0.048034813,0.11161641,0.044934433,-0.038844477,-0.08841384,-0.005607563,0.0017448851,0.0917041,-0.013662249,0.041163836,-0.105939284,-0.019558212,0.042200625,-0.018906342,-0.05626712,-0.066752024,-0.086040996,0.0019628813,-0.051175967,-0.033220213,0.023898939,-0.002954204,-0.0035897305,0.013558502,0.12813099,-0.042945717 +2.7.7.80,"Adenylates the C-terminus of the small subunit of the molybdopterin synthase. This activation is required to form the thiocarboxylated C-terminus of the active molybdopterin synthase small subunit. The reaction occurs in prokaryotes and eukaryotes. In the human, the reaction is catalysed by the N-terminal domain of the protein MOCS3, which also includes a molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) C-terminal domain.",384,0.99999994,-0.043181002,-0.093290195,-0.120592594,0.0018654567,0.023029001,-0.017985096,-0.06108603,-0.015295357,0.0860536,-0.037233733,0.04195753,-0.029826362,-0.04718809,0.020822747,-0.042114288,0.050639234,-0.07265845,0.009161052,0.031519555,-0.031790823,0.0118101,0.05263831,0.04598501,-0.014533073,-0.0237925,0.005724647,0.002870049,-0.046510678,0.029935705,0.0038996274,-0.011811947,-0.043160535,0.008187037,-0.031966865,0.0826521,0.11614291,-0.024418967,-0.03492067,0.034109432,-0.016040066,0.02615753,0.02549006,0.0024996055,-0.029435046,-0.013138861,0.031433254,0.022717053,0.018272176,0.02498358,0.014694044,0.08016647,-0.09109751,-0.0691732,0.032708306,-0.00023994889,-0.004285075,-0.100588605,0.070063725,0.13690309,0.022331422,-0.045676235,0.04836342,0.09095924,-0.0015928576,0.13650651,-0.12181501,0.05541832,-0.03733088,-0.03455598,-0.04344148,-0.09179268,-0.0070439675,0.049252514,0.023623662,-0.015193696,0.012334412,0.00091739354,-0.02085367,0.03663002,-0.004598234,0.06878116,0.055555943,0.034430925,0.06465633,-0.001286917,-0.061476827,-0.01614619,0.019776061,0.015261611,-0.009951048,0.00858558,-0.0630878,-0.018968888,-0.015740916,-0.07931238,-0.028103143,0.09316338,0.037064224,-0.016795825,0.014690181,-0.014203055,0.019828206,0.01958769,-0.06173547,-0.0074604885,0.011340317,-0.034513686,0.099312246,-0.026510103,0.06681989,-0.027870651,0.047537886,0.026571427,-0.029546395,0.04907354,0.026795521,-0.070305444,-0.012311698,-0.032208033,-0.019147487,-0.04866098,-0.018536428,-0.022493765,0.079439566,-0.060896974,0.022489034,-0.054768767,2.0092132e-33,0.13061872,0.08685989,0.08246022,-0.026201716,0.044201985,-0.019297665,0.011620548,0.0025513894,-0.0238664,-0.026495656,-0.0071367123,-0.11269227,0.060200978,-0.012365096,-0.006174287,-0.018430956,-0.080857456,-0.033183288,0.033258855,-0.001986894,-0.043913685,0.0020705038,-0.009892056,-0.015823124,0.016301522,0.0061280746,-0.06616142,0.041923057,0.048690915,-0.018093463,-0.013539886,-0.055043478,-0.07330004,-0.027936919,0.051399484,-0.06803256,0.027502868,-0.102937035,-0.001953388,0.039721906,-0.06657469,-0.024173617,-0.012828062,-0.09571113,0.05257268,0.017019091,0.0076914695,0.054250356,-0.026980931,0.028030634,0.027701091,-0.07339273,0.06172912,-0.07535733,-0.053975973,-0.045063585,-0.056675952,-0.09939653,-0.017153148,0.047062367,0.019017164,-0.009302654,0.0021137958,0.018191863,-0.0700447,-0.025383458,-0.119259246,-0.06147733,0.037817817,0.043379582,-0.048710637,-0.027402518,0.04418038,0.008335052,-0.00752499,-0.0077812998,-0.0307022,-0.016688675,-0.0007967026,0.015194023,-0.013667516,0.01652798,-0.015279275,-0.0695489,0.048225645,-0.022283882,-0.091268666,-0.0909857,-0.067100465,0.07083033,-0.020929024,-0.0357383,-0.058932684,0.07511734,-0.002187999,-3.2927187e-33,0.10766886,-0.06726251,0.053000003,-0.15204059,-0.082520925,0.039711826,-0.0018452513,-0.024093196,0.011570241,-0.038713798,0.006912501,0.0046411417,0.061353974,-0.06901948,0.02364369,-0.025535164,-0.0047556236,0.07107856,-0.010559057,-0.02530143,0.09027372,-0.03146048,-0.042717375,0.05155809,-0.00381211,0.023309663,-0.01751505,0.06541564,0.0848528,0.08076858,-0.01599286,-0.03301893,-0.10467573,0.02674409,0.01169023,0.019886786,-0.013530216,0.020186614,0.014868574,0.011183314,0.059608888,0.040569432,0.0038728446,0.11208334,-0.003032401,0.094888136,0.014184435,0.045745764,0.056927606,-0.07324777,-0.0013596386,-0.0649997,0.018067518,0.026957307,0.008943376,0.09884997,0.03169693,-0.0080613755,0.051149257,-0.04703201,-0.033609785,-0.04408285,0.020830669,-0.012365314,-0.0057193446,0.0699763,-0.038285382,0.0620953,0.1359254,-0.016831905,0.01131668,0.001371536,-0.03105968,-0.04626332,-0.029144786,-0.049985852,-0.034655277,-0.050913293,0.028853681,-0.03928532,0.006226024,0.058462225,0.023817962,-0.07400402,0.07687128,0.04117075,0.049639966,0.12821133,-0.009084249,0.034685835,-0.022888312,0.03567319,-0.0011061718,-0.009372692,-0.017097121,-3.837075e-08,-0.02110135,-0.057231814,0.023173442,-0.05098723,-0.0042764223,0.15301393,0.033398837,-0.002339486,-0.034802314,-0.019070223,0.035584327,0.06504232,0.027541546,-0.045429077,0.042852726,0.074521065,-0.032236986,0.045329772,0.012844735,-0.05498912,-0.024106104,-0.045702957,-0.040770553,0.13993406,-0.022450648,-0.02846234,0.037945155,0.10112684,-0.051302508,0.04647531,0.029154649,-0.022623751,-0.040834304,-0.02099303,0.039071728,0.00059750356,0.003086956,-0.03889062,-0.04081291,-0.06327997,-0.014945003,0.04456724,-0.01554361,0.02310288,0.026867632,0.044022504,-0.02254143,0.122705854,-0.039357346,0.037275363,0.047725435,-0.07521307,-0.034748875,-0.024171395,-0.07756217,-0.05497755,-0.023789492,-0.10470364,-0.04537967,-0.011596006,0.009855856,0.04136783,0.14605576,-0.035223328 +2.8.1.11,"The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of EC 2.8.1.12, molybdopterin synthase. In the human, the reaction is catalysed by the rhodanese-like C-terminal domain (cf. EC 2.8.1.1) of the MOCS3 protein, a bifunctional protein that also contains EC 2.7.7.80, molybdopterin-synthase adenylyltransferase, at the N-terminal domain.",384,1.0,-0.07294684,-0.07009748,-0.11713731,-0.0021378058,0.043389075,0.0020186156,-0.08866595,0.02766199,0.07627223,-0.059298642,0.039119393,-0.036170375,-0.04951554,0.0080291685,-0.039395873,0.026220076,-0.038374193,0.001018351,-0.0035223782,-0.031221118,0.022415161,0.03407703,0.02299066,-0.004549015,-0.002520552,0.028075075,0.039358784,-0.037015725,-0.0027358339,-0.01302406,-0.0041244756,-0.052093815,-0.0017734922,-0.06899206,0.048311878,0.1106574,-0.023719925,-0.0629406,0.045009293,-0.020247098,0.0037394003,0.020560076,0.019666547,-0.065875106,0.0056724027,-0.017680122,0.038682092,-0.0076264725,0.024899276,0.0086496,0.059441302,-0.0593867,-0.06130708,0.053316377,-0.01660587,-0.0036162438,-0.14413768,0.06336655,0.097533576,0.026527425,-0.022065606,0.05597702,0.11336111,-0.00562051,0.09297086,-0.11526634,0.04057785,-0.05126489,-0.0038615328,-0.04706161,-0.09815535,-0.00490321,0.03626741,0.02099562,-0.010576589,0.038120754,-0.008305278,-0.01760479,0.091569036,-0.014825334,0.055940542,0.022529075,0.006389011,0.048788268,0.010527188,-0.038298298,-0.028780915,0.03960188,-0.028431254,-0.0018809966,0.057975445,-0.07773577,0.01168989,-0.01779964,-0.0506542,-0.0130013535,0.027527794,0.09712263,-0.05432845,0.014487531,-0.030731821,0.06313412,-0.023561742,-0.07478346,-0.017307576,0.001770766,-0.0076165614,0.11037144,-0.0040624565,0.03707899,-0.032219235,0.020035021,0.026022794,-0.044274714,0.046517733,0.11573258,-0.068928,-0.023719423,-0.052965507,-0.0043156384,-0.024721043,-0.024672024,-0.009097142,0.083042,-0.021541253,0.016546821,-0.06357527,1.5216961e-33,0.13596088,0.08633928,0.09993102,-0.033317417,0.04338137,-0.017125119,-0.03504685,0.05960819,-0.0030601681,-0.01270861,-0.01827319,-0.073699065,0.02211061,-0.044439882,-0.020209102,-0.0069821673,-0.07440304,-0.044081844,0.04387486,-0.02788853,-0.033703372,-0.0014688374,0.003525192,-0.01563939,0.034346994,0.0100937635,-0.05544936,0.030242149,0.06711498,0.008888798,-0.018041069,-0.10770431,-0.08023881,-0.005404457,0.007915073,-0.07580605,-7.519612e-05,-0.09629013,0.03023096,0.021005886,-0.046547666,-0.033347975,-0.01026611,-0.080946915,0.040918328,0.0076265987,-0.014573946,0.048220687,0.011928305,0.014030003,0.038037155,-0.0649013,0.06112429,-0.027036166,-0.043155387,-0.06581457,-0.050531495,-0.06933983,-0.010083249,0.100983426,0.029455762,0.06078761,0.021272242,-0.013533352,-0.051504757,-0.021128632,-0.12983195,-0.03795768,0.015337203,0.065901816,-0.0109985,-0.030732121,0.061959192,-0.002606059,0.013466474,-0.042435694,-0.048542406,-0.01954337,0.021483561,0.018225016,-0.036564894,0.04177023,-0.0290328,-0.036421932,0.029008768,-0.0047681653,-0.058593147,-0.092895545,-0.021034805,0.07265842,-0.017210713,-0.039985534,-0.0855811,0.044363752,-0.023857428,-2.3545993e-33,0.08086626,-0.06281869,0.02753672,-0.1226326,-0.04287126,0.007045493,0.017262913,-0.004019811,0.031525325,-0.06049585,0.040237393,-0.011886235,0.07215598,-0.07736881,0.06018597,-0.023940496,-0.015079198,0.045981262,-0.006844453,-0.056498136,0.05504389,-0.027261067,-0.02473347,0.058696277,-0.010410287,0.020039732,0.010686474,0.06694908,0.11128765,0.08327499,-0.018137032,-0.017289942,-0.109585814,0.021658115,-0.00728687,0.013569427,-0.018919636,0.023807675,0.007901708,-0.026975676,0.062413037,0.009952592,-0.041240375,0.13131475,0.03794472,0.09723255,-0.0018034163,0.047829084,0.044999734,-0.037965085,0.024454495,-0.04249145,0.008519269,0.041660838,0.008760943,0.104519814,-0.019407475,-0.003923625,0.035842795,-0.017024659,-0.034209736,-0.048837516,-0.0025226627,-0.017425966,0.004375709,0.07555676,-0.019428128,0.066406555,0.1274625,0.002227432,0.031873707,-0.05364178,-0.03369973,-0.015025699,0.0033922556,-0.03849243,-0.03381582,-0.024099609,0.041787602,-0.04951991,-0.0071911737,0.0442076,0.03438018,-0.08140476,0.10452109,0.00903126,0.028723607,0.1651326,0.0122697195,0.028694034,-0.03058683,0.033973813,-0.056091983,-0.01815134,-0.00483396,-4.2565553e-08,-0.015875004,-0.09725032,0.072683446,-0.011568626,0.017200839,0.13597918,0.022999428,0.008870359,-0.048654497,0.013422965,0.0012319282,0.06470982,0.0025906293,-0.0796485,0.004421967,0.093618274,-0.029059226,0.090670146,0.020523816,-0.031983905,-0.020359017,-0.025994865,-0.0674921,0.097336546,-0.029615093,-0.024124062,0.008716962,0.058446005,-0.06426705,0.049057625,0.06506651,-0.013791148,-0.0056608985,-0.010167675,-0.011044934,-0.050829444,-0.011095962,-0.020281876,-0.06927768,-0.06314005,-0.031270392,0.046586677,-0.036900736,0.02366425,0.05571081,0.024724111,0.0020215365,0.102804825,-0.02616519,0.032618012,0.03603016,-0.065531865,-0.012025296,-0.06346872,-0.06360447,-0.06280546,-0.03447725,-0.108598225,-0.017084291,-0.028376775,0.038926776,0.016538417,0.16240619,-0.0034172365 +2.8.1.12,"Catalyses the synthesis of molybdopterin from cyclic pyranopterin monophosphate. Two sulfur atoms are transferred to cyclic pyranopterin monophosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor. Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur-carrier proteins) that are thiocarboxylated at the C-terminus by EC 2.8.1.11, molybdopterin synthase sulfurtransferase. The reaction occurs in prokaryotes and eukaryotes.",384,1.0,-0.04267538,-0.073367916,-0.10186325,-0.022375835,0.064807676,0.009843305,-0.056899216,0.008442944,0.031120416,-0.018465504,0.033062436,-0.00040998764,-0.061228946,-0.0069155176,-0.052812304,0.0776615,-0.047873907,0.016744731,0.036435176,-0.005374069,0.050745428,0.0050050514,-0.0014593701,-0.0142107,0.029794717,0.043943603,-0.0355733,-0.05304942,0.005340799,-0.0004626649,-0.018857239,-0.023945615,-0.012441358,-0.043564223,0.02798104,0.105244815,-0.044685036,-0.0369014,0.06402344,-0.07090179,0.042444713,0.04370002,-0.031370204,-0.07566693,-0.027414048,0.012996185,0.019434687,0.043578085,0.015901892,-0.050151613,0.058479723,-0.07209442,-0.047285594,0.051775496,0.023023956,-0.00026456694,-0.07284108,0.05317325,0.13034947,-0.008526945,-0.0055306084,0.06641625,0.09207672,-0.011370975,0.085540086,-0.08358511,0.037166115,-0.011929378,0.008348384,-0.054905288,-0.10145361,0.049743675,-0.015374013,0.04701419,-0.029020123,0.04813192,-0.014498808,0.019280663,0.016790653,-0.05161123,0.056883276,0.053254273,0.035006784,0.04145339,0.027669912,-0.08473895,0.0011748443,0.08172798,0.03161651,-0.050243687,0.048477266,-0.015814766,-0.010150019,-0.0093774265,-0.046841156,0.023006022,0.038469028,0.110122584,-0.026276225,0.02302709,-0.022211675,0.025887812,-0.037546594,-0.0696555,-0.06580894,-0.007661474,0.0020790133,0.07202545,0.0053021694,0.056921396,-0.03192381,0.0109734675,0.035849717,-0.035590183,0.014466595,-0.0013494678,-0.05012346,0.024809869,-0.06828875,0.0035434808,0.03014642,0.0019539783,0.025702102,0.085846126,-0.05697628,0.072736815,-0.10041026,7.226479e-33,0.12668964,0.11098903,0.09247934,-0.019917477,0.057366494,-0.023128252,-0.012306698,0.03705023,0.0016505994,-0.04014782,-0.025543151,-0.13302284,0.040683784,-0.04548818,-0.012876008,-0.046566296,-0.054832358,0.002480983,0.0823426,-0.00076814706,-0.047807958,0.006011979,-0.050379578,-0.023278972,0.021932403,0.022389863,-0.034928177,0.018442858,0.055284508,-0.018742885,0.013742141,-0.093300104,-0.08125075,-0.0012613696,0.07047132,-0.106877625,0.0071722646,-0.079288684,-0.01680892,-0.03268366,-0.047028456,-0.03038033,-0.03035212,-0.08299942,0.062532485,0.011679728,-0.026909983,0.038167004,0.03251898,-0.046010196,-0.009261392,-0.07379796,0.03297442,-0.08373435,-0.054055743,-0.030067118,-0.0043315897,-0.07952657,0.04111005,0.0648574,0.02692654,0.030170778,0.014493094,0.003134223,-0.03722955,-0.019563152,-0.09646774,-0.034162283,0.03577714,0.04095569,-0.06024909,-0.04229073,0.014573296,-0.0033852966,-0.0057380446,-0.044727296,-0.0062527442,-0.08234333,0.0025288174,0.015850933,-0.008010355,-0.019430848,-0.0018494752,-0.09100944,0.037136015,-0.029695015,-0.13129412,-0.09033212,-0.0036991052,0.08843597,-0.027270148,-0.026599834,-0.08292011,0.029049037,-0.034142926,-6.7979345e-33,0.10537994,-0.0016365199,0.053861704,-0.14028062,-0.05300019,0.04137975,-0.0067738807,-0.008194282,0.067296356,-0.02445414,-0.0031688972,-0.041220278,0.058192745,-0.072039925,0.0016785127,0.023384297,0.033127096,0.09092655,0.019757906,-0.0154489605,0.05614181,0.013268212,-0.038072474,0.049451265,0.029188437,0.04405372,0.018285021,0.091440156,0.12154033,0.08144087,-0.002443534,-0.020797323,-0.08084807,-0.026295565,-0.05210407,0.027325293,-0.04654799,-0.023100358,0.04997309,-0.0020225735,0.02967699,0.03205711,0.04206013,0.083316736,0.03240156,0.02445824,-0.010258629,0.031938393,0.0527727,-0.06139859,0.043390077,-0.04687556,-0.023700342,0.034784343,0.00942848,0.07200956,0.034515902,0.03560818,0.010477144,-0.053443342,-0.019860234,-0.05017666,-0.0070761046,-0.025378508,-0.0061028874,0.09033162,-0.040647376,0.037878226,0.10132925,-0.022768054,0.00345293,-0.028081467,-0.047686633,-0.016181538,0.013393986,0.004237962,-0.018980125,0.017391961,0.024660172,-0.017391266,-0.0069594523,0.059672534,0.015646625,-0.10861369,0.03993345,-0.01868619,0.030957652,0.12199872,-0.031799488,0.028075587,-0.04203583,-0.010305035,0.002006301,0.07426037,0.028147407,-3.8294655e-08,0.001792044,-0.08742239,0.051936597,-0.030978434,0.012454259,0.080374226,0.054700222,-0.013727986,-0.047178257,-0.060828164,0.017765597,0.03280247,0.032329764,-0.03640026,0.040207017,0.10153414,-0.067659564,0.029402366,-0.025271427,-0.034599226,0.03987391,-0.03876301,-0.06437136,0.157046,-0.0347478,-0.06251362,0.0031934083,0.049814,-0.041660715,0.027808504,0.035277188,-0.016297873,-0.046388414,-0.031402797,0.010510906,0.00654757,-0.04228227,-0.06280677,0.02202391,-0.055387396,-0.039970957,0.04596832,-0.020689074,0.028362399,0.029088905,0.013276057,-0.043641604,0.10287795,-0.072832845,0.049124427,0.10214974,-0.061088588,-0.009722731,-0.087590635,-0.094770245,0.0037774607,0.015241789,-0.07004488,-0.01935372,-0.020699756,0.011418974,-0.003037112,0.18733463,-0.011667513 +3.1.1.89,A key regulator of protein phosphatase 2A. The methyl ester is formed by EC 2.1.1.233 (leucine carboxy methyltransferase-1). Occurs mainly in the nucleus.,384,1.0,0.0037300081,0.04686459,-0.04189843,-0.052600224,0.07131536,0.08411082,-0.04967136,0.03596281,0.027425325,0.0082570715,0.03349626,-0.023719613,-0.052642472,-0.032595042,0.030791836,0.04789421,-0.11336788,-0.0022850556,-0.02791175,-0.059573695,0.09408505,0.021667281,-0.05234883,0.031408846,-0.017120821,-0.036721762,0.054772384,-0.0044347225,0.028704122,-0.087718226,0.02240603,-0.0808356,0.015927475,-0.037459854,0.020215,0.011931775,0.0025029855,-0.078119665,0.0023233243,-0.0064827604,0.08753727,0.029112158,-0.019889675,-0.06571344,-0.069433205,0.04435093,0.044793606,0.019641623,0.024164699,-0.055541765,0.006034269,-0.072197326,0.010358615,-0.00021415474,0.0027873628,0.085253716,-0.08031155,0.033225868,0.042014804,0.004827656,-0.06781813,-0.026180223,0.01996392,0.0066114007,0.051707797,-0.00030936697,0.0266803,-0.05365093,-0.07314567,0.008229905,-0.056771208,-0.09936424,0.011073926,0.038818672,-0.0042955917,-0.003019056,-0.019297602,0.009192791,0.078588314,-0.012316247,-0.014997036,-0.04188552,-0.020216113,0.014913402,-0.007339531,-0.025736813,-0.054272585,-0.011013177,0.012620558,0.10472954,0.016604064,-0.08289564,0.0637809,-0.023539018,-0.011603314,0.0888375,0.055530433,0.026193874,0.10040563,-0.03380434,0.018748164,0.0957463,-0.08940175,-0.06619318,-0.05310127,0.007039071,0.04861898,0.074183285,-0.037352543,0.055278804,0.07543779,0.028689254,0.05341908,-0.015434837,0.010461991,0.04411445,0.005106369,-0.049896333,-0.05968711,-0.06584386,0.01756922,-0.053115513,-0.00038218766,0.0491297,-0.024657302,-0.027818557,-0.170877,5.198819e-34,0.0095337685,-0.019316468,0.003919992,0.03008506,-0.020699723,-0.0020929482,-0.035820737,0.03566472,0.01349434,-0.12228291,-0.04365327,-0.14026465,0.020778712,0.031084923,-0.053002845,-0.07769449,0.011120024,0.050824072,0.025374813,-0.06322914,-0.0021607627,0.00052202155,0.0033334058,-0.013783324,0.02171992,0.06490194,-0.04090278,-0.02921302,0.06639202,0.0072079822,-0.024792781,-0.0667121,-0.06473098,0.045536753,0.03297621,-0.02638991,-0.011409059,-0.0003645436,0.015209144,0.07524266,0.049645156,-0.002944077,-0.050851297,-0.04150727,0.036843937,-0.03843016,-0.010319818,0.055121135,0.08508972,0.0012988979,-0.022406021,-0.058959488,0.033622213,-0.01995357,-0.030540694,-0.012649145,-0.098913364,-0.08642743,-0.045100458,0.062517606,0.012290714,0.095172316,-0.028815554,0.06455317,0.003939821,-0.010265243,-0.0794635,-0.1261801,-0.053936414,0.07117365,0.036031924,-0.05185758,0.10909623,0.0055347155,0.0360213,-0.0182358,-0.05895833,0.012525191,-0.03757386,0.07695181,0.010111229,0.029652163,-0.01615894,-0.0143292425,-0.0018695816,-0.027626324,0.016501011,-0.066604,0.03961983,0.06529419,-0.004064916,-0.12721114,-0.029946584,0.06325778,-0.019765493,-2.3853495e-33,0.08220196,-0.05437304,0.13896486,-0.11081613,0.018245494,0.08167046,0.05099533,-0.052454807,0.027037406,-0.052394267,0.05151723,-0.005199467,0.02049442,-0.058154438,0.06732494,-0.024746247,-0.0059978347,0.055559292,0.02134439,-0.020813521,0.008812113,0.012954254,-0.00029510786,0.14526087,0.050422132,-0.0056911316,-0.09187155,0.15853405,0.07027925,0.06297679,-0.07936444,0.05165817,-0.022144366,-0.027757367,-0.0038450882,0.038883023,-0.108339034,-0.015769878,-0.018108318,0.05729261,-0.041228883,0.04410585,0.038220953,0.023461385,0.06741226,0.013028507,0.027589425,0.0364668,-0.016031241,0.00047936226,0.0251919,-0.01875726,0.008499503,0.082258694,-0.0007054971,0.018697446,-0.020847257,0.09081661,0.05541535,-0.012191516,-0.032095596,-0.05184594,-0.05654967,0.03983587,0.031830754,-0.028714526,0.0018475945,-0.027034378,-0.010997506,0.07623797,0.064708665,-0.019953726,0.012964784,0.05869663,-0.015044443,-0.031031657,-0.12242008,-0.033434402,-0.004750718,-0.010452923,-0.04139232,0.04452874,0.017943075,-0.107219495,0.009944177,0.019393725,-0.014017674,0.045291215,-0.034260437,-0.002738394,-0.0680304,-0.054151636,-0.07718591,0.09919352,-0.014094338,-3.5958312e-08,0.018491313,-0.0945371,0.020367173,-0.047693923,-0.008122426,0.01596547,0.033705838,0.023789763,0.015169466,-0.0076356926,0.027589781,0.010651437,0.019320684,-0.054337535,0.05833799,0.044951066,-0.026707625,0.08942821,0.008600044,-0.041818544,0.053827804,-0.032168526,-0.056837056,0.017810782,-0.0046242927,0.015565784,0.0023255148,0.10166297,-0.008699388,-0.016575767,0.08431337,0.015281482,0.058704246,-0.034240406,-0.018157724,0.028063571,0.011940986,-0.035655804,-0.012100648,0.068595804,-0.0024635526,0.02353773,0.0029733726,0.003838116,-0.0073269224,0.019373689,0.014511522,0.041611843,-0.012493263,-0.059320822,0.020937229,-0.052950215,-0.023389705,-0.05779018,-0.056750607,-0.10610808,-0.064699054,-0.042348932,0.012602919,0.017966341,0.06544233,0.117825516,0.118273824,-0.059805132 +3.1.1.90,"All-trans-retinyl esters, which are a storage form of vitamin A, are generated by the activity of EC 2.3.1.135, phosphatidylcholine---retinol O-acyltransferase (LRAT). They can be hydrolysed to 11-cis-retinol by EC 3.1.1.64, retinoid isomerohydrolase (RPE65), or to 13-cis-retinol by this enzyme.",384,1.0,-0.06923272,-0.026927492,-0.069701284,0.02569802,0.0237141,0.076251894,-0.015625022,0.061888482,0.02982396,0.003772937,0.0936459,-0.049276955,-0.055264685,-0.032035768,-0.06218695,-0.012865168,-0.06464345,0.0492465,-0.05207613,-0.084153526,0.029319037,0.030377742,0.015856221,0.06495226,0.026464235,-0.07283409,-0.01447569,-0.0077454615,0.048600987,-0.04920425,0.0061134086,-0.050848417,-0.029312467,-0.05988573,-0.007280517,0.068071835,-0.02026967,-0.09222269,-0.01657538,0.07172233,0.058659095,-0.036788013,-0.026512748,0.002768142,0.118844315,-0.07230015,-0.023132974,0.020794624,-0.009769414,0.05382457,-0.0051694433,-0.026025932,-0.10791352,-0.018133124,0.017066825,0.025457926,-0.040539898,0.017508378,0.055283066,0.13628814,0.027017787,-0.015522982,0.07918843,-0.04792269,-0.048440374,-0.046994574,0.031375144,-0.04207976,0.04847613,-0.0710518,-0.100778505,-0.093806714,-0.022807004,0.028267967,-0.0028935696,0.009742167,-0.0552275,-0.017766774,-0.02336242,0.04460934,0.053298295,-0.0707806,-0.08538706,0.07949531,0.07020809,-0.0973537,0.004388167,0.0071373475,0.03998716,0.093741454,-0.05336558,0.017537791,-0.0026643802,-0.02151365,-0.030270588,0.036518782,0.0008826652,-0.013425018,0.032660816,-0.039024275,-0.023778269,0.020048995,-0.0028414784,-0.025073929,-0.1298963,-0.031468965,-0.0252544,0.09006696,-0.03890228,-0.02574846,0.0058796685,0.012448262,0.003614785,-0.03541818,-0.009366036,0.078453325,-0.04759254,-0.1010805,0.056031372,0.033100046,-0.013506834,0.038377073,0.11550597,0.04135496,0.047837045,-0.034891643,0.004358853,8.715134e-34,0.03515169,0.114862986,-0.019236572,0.11445897,-0.10761386,0.05914034,-0.10078568,0.09119266,-0.033236567,-0.1334033,-0.03626751,0.026104383,-0.0062405276,0.09499052,0.051249012,-0.05243314,0.06364029,-0.014284155,0.008726599,-0.046016812,-0.037630856,0.04414123,-0.016162839,-0.0006040501,-0.01648566,0.002533876,0.005684845,0.026278187,0.018052792,-0.015130452,0.04717292,-0.029249733,0.0005111109,-0.008883955,0.03978162,0.060160547,0.0025395255,0.005404402,0.02337454,0.06300169,0.04593104,0.042380948,0.021624135,-0.04187135,0.07408635,-0.011100448,-0.05187099,0.04125499,0.017620314,0.01103683,-0.004186626,0.027401322,-0.012038682,-0.018217133,-0.05964677,-0.040797457,-0.11704962,0.039440997,-0.030238869,0.039852496,-0.028192414,0.091648884,-0.057464954,0.046639495,-0.050260786,0.0126119405,-0.021071885,-0.04644435,-0.04617325,-0.015335321,0.05198754,0.011079292,0.15694985,-0.050184608,0.053673517,0.011835585,-0.11636606,0.10745038,-0.031734426,0.0014754458,0.00922178,0.05388489,0.0066662626,0.0359069,-0.011602122,-0.04054556,-0.006804412,0.0335528,0.11426947,-0.008800188,0.04444764,-0.068979904,-0.011249534,-0.006426816,0.0053851237,-2.1061215e-33,0.05684467,-0.06451641,0.020213334,-0.035279486,-0.009082906,0.003043445,0.019274104,0.030950623,0.019545645,-0.03937965,0.04144693,-0.04824154,0.050452795,-0.08570624,0.005169496,-0.09119195,-0.011216467,0.0150423525,-0.019299755,-0.0077389055,-0.028693875,-0.06070767,0.07140059,0.10070235,0.04871485,0.07913113,0.012583381,0.038479924,-0.014690287,0.025093034,-0.03929277,-0.09573028,-0.018408157,0.011340629,-0.00032742412,0.05349987,-0.046739753,0.02704288,-0.03765978,0.040714793,0.0152142085,-0.049334034,0.0064020595,-0.023022834,0.045392416,0.074305415,0.016203506,0.0010446662,0.039340984,-0.016690634,0.050896,0.011201651,-0.039855935,-0.04249018,-0.012577556,0.018381646,-0.07930859,0.025394268,0.04994744,0.0069420706,0.04726777,-0.09671959,0.007779833,-0.021889327,-0.03146255,0.0104061775,0.06612456,0.014594422,-0.028153429,-0.012360744,0.15619646,-0.007476929,0.029634494,-0.00439155,-0.0043212017,-0.06351425,-0.03294836,-0.093303494,-0.047691945,-0.09284665,-0.02140178,-0.106050014,0.02396028,-0.021646643,0.036277946,-0.04555542,-0.056601636,0.0021142736,0.020085916,0.0060930443,-0.059740473,-0.041450784,-0.13671654,0.04164632,0.0940348,-4.310234e-08,0.0770018,-0.011470714,0.032060232,0.016441302,0.046136133,0.027306434,0.0026839261,0.03445719,0.07293045,-0.0032024952,-0.013587061,0.029844956,-0.035223506,-0.024650358,0.026163256,0.05254118,-0.012571128,0.08910141,0.026479475,-0.017654082,-0.05947611,-0.013547602,-0.0009198685,-0.051446296,-0.07695075,-0.035998646,-0.0043435544,0.04900309,0.072876655,-0.041801833,0.12088989,-0.027691625,0.10839866,0.008329174,-0.05204828,0.0002654378,0.044512097,0.04004422,-0.05086298,0.05566283,-0.03960961,-0.04149881,-0.043982603,0.05729353,0.0037499266,-0.038083684,-0.0053994567,0.01095358,-0.013021814,0.003872507,0.025476964,-0.07466322,-0.02543367,-0.061972406,-0.080728166,-0.05393583,0.004068266,-0.046319116,-0.02771259,-0.031611316,-0.006122948,0.022752166,0.106596425,0.041863654 +3.1.3.86,"This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.",384,1.0000001,-0.06915253,-0.038165547,-0.053254403,-0.050107535,0.038851205,-0.0064252997,0.043038018,0.059503317,0.06553143,0.06394818,-0.05427029,0.023422146,-0.0006186176,0.035013672,-0.074290834,0.061738633,-0.028886732,0.06030952,0.035031717,-0.101338305,0.017343502,-0.031467907,-0.030090561,0.056077443,-0.07477745,0.026658379,0.08010433,-0.0034329444,-0.046591774,-0.034803268,-0.07077091,-0.06485472,0.037398666,-0.057317603,0.008904154,0.16122052,-0.05037929,-0.06209003,-0.02440884,0.0057382337,0.10046844,-0.05249866,0.0056991824,-0.07147394,0.021436818,0.032949176,-0.0721971,0.044148058,0.11535994,-0.010322317,-0.049344532,-0.030404689,0.026015641,-0.0036134282,-0.051297374,0.014778539,-0.10017424,0.108593695,-0.014992202,0.060563132,-0.029126674,-0.0265004,0.0044494346,0.08764362,0.05942689,0.021156345,-0.026218962,0.0029340445,-0.06868854,0.015009682,-0.06474881,0.0156213865,-0.009429021,0.026313026,0.028121678,0.05392164,0.005109063,-0.0315191,-0.0024511497,-0.047031436,0.042315412,0.0070108427,0.026932828,0.035687253,0.015604548,0.014504212,-0.035697624,-0.013402205,0.040130418,0.08518475,0.04574039,-0.02438988,0.017958684,0.051735595,-0.019178385,0.06714899,-0.040664572,-0.012443532,-0.027910657,-0.04222533,-0.0410652,0.030421788,-0.050224096,-0.030002676,-0.005069233,0.05380966,-0.006401753,-0.04174814,0.03310337,0.05362782,-0.023619754,-0.045429442,0.037702072,-0.053454112,0.004555044,0.11529796,0.009148448,-0.080115676,0.04327766,-0.01347465,0.04849627,-0.08052502,-0.048328605,0.072571196,-0.105883904,0.031488113,0.008434134,1.7661156e-33,-0.0040651783,0.034819882,-0.0017729768,0.012153014,0.013497681,-0.024306405,0.02465255,-0.09334107,-0.10613193,-0.016772097,-0.01700011,-0.08950642,0.056298427,0.046687502,-0.06676968,0.018978963,0.0037697784,0.036357436,0.032319773,0.052368257,0.0140714,-0.015361266,-0.08129189,0.017541377,0.011345271,0.11853053,-0.054606374,0.009944802,0.027994074,-0.011167538,-0.02376207,-0.012291788,-0.05867519,-0.0026841261,-0.04840183,-0.06329851,-0.036682602,-0.056552693,0.010768986,0.07245178,-0.06806958,-0.08867906,-0.04333626,0.022761706,0.049145978,-0.076286934,-0.04961965,0.009319987,-0.04076004,0.056393776,0.06601149,-0.012999146,0.06034964,-0.009841207,-0.051733013,-0.08749903,-0.030706968,-0.03469367,0.07435897,0.011515115,0.0051738364,0.021343537,-0.01582702,0.054070864,0.006457263,0.017489986,-0.048633408,-0.06021314,0.018917777,0.11058663,-0.02959736,-0.01644486,-0.0053668274,0.022829834,0.05019196,-0.03428889,0.017154362,0.043392867,-0.07833415,0.061999567,0.01476389,-0.04473744,0.058937535,0.11291916,-0.028993651,-0.0038240848,0.037491783,-0.06634575,-0.024043571,-0.0618047,0.09204198,-0.0005821564,-0.0016633713,0.102766275,-0.06539369,-4.274771e-33,0.06362683,0.018796772,0.045745097,-0.12974674,-0.12262134,0.059813365,0.071201965,0.0044917045,0.11638678,0.05162194,0.07809906,-0.06090737,-0.009517013,-0.04528103,-0.04896155,0.048767187,-0.018688235,0.02806389,-0.05343303,-0.017904505,0.0042043417,0.08201993,-0.017280817,0.12028312,0.012715554,-0.044264536,-0.04793445,0.013687574,-0.039019194,0.10906963,-0.019356888,-0.0024587433,-0.015392505,0.0069718184,-0.0010196834,0.024846753,-0.05031084,-0.037103835,0.025704458,0.0068880483,0.02082671,0.023638658,0.07971914,-0.021748073,-0.04280394,0.048578322,-0.018366126,0.098002024,-0.05637597,-0.046928037,-0.0607587,0.07460482,0.057533454,0.06951972,0.030522939,-0.007881794,0.032922894,-0.0120082665,0.00205669,-0.016962122,-0.06747819,-0.07177537,0.04934281,0.06763474,0.07532593,0.067604646,-0.0028121835,-0.0092679905,0.037853416,0.042767666,0.013975215,0.013785314,0.026027141,0.020822087,-0.032441117,-0.019258732,-0.063808374,0.039672863,0.02641986,0.015208422,-0.0029524756,0.0042329803,-0.018872116,-0.13825913,-0.009844038,-0.0537809,0.001147958,0.09941361,0.0037264861,0.0425207,0.0053736446,-0.01064476,-0.105711214,-0.026548697,0.03580739,-4.59569e-08,0.10179317,-0.06071038,0.019506197,-0.061136223,-0.06480285,0.020094592,0.010070491,0.05406065,-0.0135433525,0.005046095,0.0009875471,-0.016364433,0.060861677,-0.035485737,0.079282805,0.104400925,-0.04729637,0.001602472,0.01301898,-0.06139611,-0.025884671,-0.033217084,-0.061710127,-0.017680854,0.059972335,-0.013119564,0.06010631,0.043175697,0.0014746946,-0.039602377,-0.045786913,0.0015674245,-0.06095206,-0.04037356,-0.020429842,0.099663615,-0.09955874,0.0009271555,-0.06362559,0.0274451,-0.081349485,0.0016237532,0.001918787,-0.006685199,-0.06949194,0.03232691,0.06425417,-0.057571895,0.028116278,-0.06510233,-0.02351357,0.014638213,-0.011202591,-0.05790317,-0.03198809,0.018712927,-0.045518473,-0.036794193,-0.047292307,-0.09723224,-0.0014586893,0.027059458,0.10260589,-0.039970577 +3.1.7.8,"Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives isotuberculosinol in 1:1 mixture, cf. EC 3.1.7.9, isotuberculosinol synthase.",384,1.0,-0.034342784,-0.07685196,-0.034474473,-0.022399517,0.023164973,0.04350777,-0.035694607,0.067399,-0.03277651,0.0055493745,-0.024214085,-0.046816774,0.119305864,0.028847376,-0.03594764,0.02784396,0.017878389,0.019782593,0.02634062,-0.04402829,-0.044657763,0.101089984,0.04809678,-0.036461554,0.04041777,-0.036970194,0.012859686,-0.023908071,0.016501844,-0.11099896,-0.035451908,-0.0400303,0.026234608,-0.10594186,0.14202194,-0.013880385,-0.04984929,-0.05052542,0.12539482,0.038020212,0.041038096,-0.033420704,0.025210725,-0.013119736,-0.01105102,0.01572671,-0.017110825,0.045954086,0.06266465,-0.011906297,-0.04504835,-0.028411409,-0.040970746,0.07533496,0.040080987,-0.065295294,0.002279371,0.036952443,0.03224839,0.04660379,0.040856913,0.02015577,0.040095016,-0.014454599,0.036910105,0.091462776,-0.05026773,-0.007862615,0.039454747,0.014717209,-0.0023015803,-0.036350027,-0.0665408,0.17005394,-0.041025072,0.017140554,0.0133372275,-0.03289704,-0.044042155,0.10361679,-0.109816834,-0.027408652,0.0070622046,-0.06202268,0.011947866,-0.027828392,0.09575189,0.019783692,0.0019071909,0.02632617,0.0026404276,-0.009985923,0.043359946,-0.06296944,-0.034806967,-0.020100674,0.07364543,0.06558097,0.053994194,-0.09875353,0.00816108,-0.04813391,0.015792426,0.0002439589,-0.046895772,0.0003403663,-0.027402943,-0.0229813,0.06279745,-0.025494711,-0.04813417,0.005228535,-0.016975679,-0.06696661,0.012959103,-0.03508387,0.16897969,-0.02000415,-0.07143285,0.014422235,0.018357238,-0.095047556,0.055081014,-0.019891072,-0.08411565,-0.01410341,-0.07641651,1.6986274e-33,-0.019714555,-0.07245479,0.06841202,-0.010463059,0.10304574,0.019518655,-0.04872174,0.009701759,0.0068410784,-0.06939259,-0.11427027,-0.04978379,-0.0028215547,0.057269804,-0.108580574,0.06528264,-0.021501683,-0.047801282,0.04258214,0.028836548,0.009969589,0.0008588524,0.021598592,0.030227236,-0.03027917,0.0063211247,-0.0022283052,-0.024512319,0.008091436,-0.016613057,-0.0038615689,-0.038511027,-0.06183366,-0.005733593,-0.026415866,-0.018651081,-0.047702584,-0.024742361,-0.004068436,0.068244144,0.03746587,0.0058721257,-0.012090777,-0.024932677,0.109002195,-0.0053038853,-0.052782364,-0.011602972,0.0072105513,-0.040870428,0.03515793,0.0019461637,-0.031906847,-0.040708385,0.06810721,-0.016043885,0.008854876,0.090251595,0.06377461,0.08426605,0.030875508,0.08713017,0.013072398,0.050093044,-0.03244693,-0.008490615,-0.036266856,0.057339046,0.0052995863,-0.022323897,-0.06275006,-0.0060455073,-0.020102937,-0.00038274442,0.10573029,-0.036606047,-0.11854049,-0.089229286,0.048126753,-0.10437695,0.011184222,-0.021724189,0.026026834,-0.020922277,-0.031545877,-0.02191865,-0.06688551,0.0059101656,-0.016542071,0.024929842,0.036282096,0.00093839125,-0.105389915,0.10989191,-0.05667437,-3.812136e-33,0.038504627,-0.09497773,0.059910286,-0.08376361,-0.013439697,-0.053038742,0.019790227,-0.027449796,0.052858092,0.011736118,0.08271868,-0.020089662,-0.0054429863,0.02574621,-0.023888595,0.007511442,0.011101617,0.009897093,-0.05121226,-0.0044644387,-0.044489305,-0.046073034,0.03816759,-0.055258907,-0.052569427,0.049209755,-0.039714098,0.0066923257,0.10479724,0.09334328,-0.04562181,0.10863039,0.021052998,-0.0827037,-0.10864556,-0.06885413,-0.030696804,-0.055512708,0.04861942,-0.06652565,0.031105923,0.08855361,-0.0062176203,0.009340603,0.041709185,0.0060839322,0.009593029,-0.076427095,-0.019913632,0.0017449197,0.047675945,-0.021861106,-0.03190326,-0.0054126517,0.0051090247,-0.012380747,-0.03828616,0.030420981,0.070748426,0.0007377168,-0.05872898,0.026213588,-0.007329807,-0.016270874,0.09403725,0.108386494,-0.02638166,0.12931752,0.01980865,0.006641966,0.09385609,-0.02082352,-0.010434646,0.0044983323,0.033014964,0.03930997,-0.03198765,0.049457673,0.033489224,0.011817997,-0.038462725,-0.0019332601,-0.043515947,-0.056716073,-0.0001704945,-0.054670814,-0.010222973,0.05735959,-0.012583296,0.07982984,-0.019639667,0.04849376,-0.07898293,0.04089803,0.0971073,-3.3094764e-08,0.011805014,0.012358254,0.04100991,0.013603198,0.061143987,-0.015930682,0.014759253,0.0708448,0.07612282,0.023792068,0.021498706,0.019243281,0.02588654,-0.025691677,0.07016598,0.02427122,-0.0044129877,-0.06668475,0.027841777,-0.014242698,-0.052061565,0.002396023,0.032147884,0.027499743,-0.05651077,-0.04666865,0.009728007,0.00064542727,-0.013072059,-0.02835622,-0.041788608,0.0017059355,-0.00085289264,-0.12876564,-0.04557518,0.03267409,-0.039790466,-0.0728602,0.022334773,-0.013409543,-0.0069652637,-0.08351729,-0.005770879,-0.011115138,0.037227232,0.029716074,-0.033196114,0.006093778,-0.04415472,-0.07666231,0.052233156,-0.08426001,0.023363538,-0.04581199,-0.02440977,0.08607081,-0.012875532,0.009161097,-0.06320354,-0.057733294,-0.045902744,-0.03570306,0.14527011,0.015571336 +3.1.7.9,"Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives tuberculosinol in 1:1 mixture, cf. EC 3.1.7.8, tuberculosinol synthase. The isotuberculosinol form was a 3:1 mixture of the 13S and 13R forms, respectively.",384,1.0,-0.020083386,-0.07457129,-0.0589984,-0.043523673,-0.010579097,0.0644782,-0.042081792,0.09744945,-0.0052611185,0.008058981,-0.009751598,-0.058768712,0.113854654,0.02996018,-0.05504256,-0.0068716095,-0.014793181,0.03506924,0.0025708475,-0.0514171,-0.022197684,0.09592571,0.07242999,-0.0135761,0.07474933,-0.015069377,0.02546292,-0.031817395,0.022676919,-0.09686003,-0.011480991,-0.019954238,0.023143979,-0.12534599,0.14976683,-0.01603152,-0.04033886,-0.036960926,0.14374933,0.039754137,0.010517687,-0.04108883,0.013873866,-0.022043237,-0.003665995,0.028370386,-0.027786935,0.07434125,0.07895916,0.017561788,-0.03334786,-0.015614317,-0.029599193,0.06825813,0.042763647,-0.072730444,-0.042976465,0.05068649,0.066233814,0.0586781,0.012794852,0.017766248,0.039182644,-0.009915782,0.0021732734,0.06499888,-0.05287647,-0.036756244,0.033572413,0.028457971,-0.025044568,-0.013731533,-0.09049483,0.12065349,-0.04653069,0.0129531855,0.009722676,-0.05212713,-0.054498784,0.11105851,-0.09381371,-0.01134356,0.011718969,-0.03407605,0.005139782,-0.027674971,0.08538479,0.016909739,0.0013920632,0.021968996,0.006428951,0.0015426542,0.046560816,-0.046232607,-0.014445717,-0.015426797,0.08686888,0.06841045,0.08006514,-0.08495339,0.02319644,-0.06371344,0.030576823,0.0066476692,-0.033854127,0.0075113503,-0.022766827,-0.008744946,0.055292092,-0.019375743,-0.027182303,-0.005274241,-0.037131526,-0.06270442,0.0037631379,-0.0043293177,0.1430307,-0.023588844,-0.0810854,0.01846195,0.027820433,-0.09480107,0.038969424,-0.003983469,-0.09014184,-0.026074352,-0.058409486,1.707579e-33,-0.009803557,-0.036367785,0.04126008,-0.0021446487,0.07349183,0.024077354,-0.03206782,0.028261444,0.008233412,-0.05548511,-0.10128023,-0.061876446,-0.0056368634,0.061727412,-0.11215904,0.046947524,-0.020411884,-0.053578332,0.04463671,0.009760374,0.0028987715,0.029629573,0.026595132,0.024893703,-0.022301964,0.0075930795,-0.02375913,-0.008413556,0.006991167,-0.0151785035,0.02869479,-0.048613112,-0.07020389,0.019281298,-0.023883093,-0.0065920427,-0.05717177,-0.031215526,0.035326637,0.056859702,0.045496702,0.0050024926,-0.00061835116,-0.023564024,0.10409837,0.02359227,-0.035611115,-0.0042484854,-0.0010875845,-0.05874868,0.039861377,0.04791927,-0.009605892,-0.043108918,0.0832298,-0.0027085936,0.0047523635,0.09088922,0.0380058,0.07401605,0.03278839,0.09519096,0.023976235,0.04491287,-0.035267193,-0.025505496,-0.03365762,0.03780417,0.009042154,-0.049413513,-0.06695319,0.042910885,-0.040950857,-0.014251092,0.1106764,-0.022173664,-0.118858576,-0.07141957,0.058119327,-0.09692214,0.019612726,0.014873971,0.012565365,-0.04101294,-0.030900814,-0.027171219,-0.073260985,-0.016707763,-0.04108193,0.016035855,0.037654888,-0.026465194,-0.117643826,0.12230138,-0.027978973,-3.577225e-33,0.02599375,-0.08771422,0.075513005,-0.05535503,-0.018976713,-0.05879758,0.031140916,-0.036646836,0.048634924,0.023023283,0.08439907,-0.016594404,-0.021778677,0.017030505,-0.05438046,0.001983075,0.023960095,0.03196691,-0.036936093,-0.013172385,-0.055011407,-0.0314518,0.021268979,-0.05331695,-0.069694676,0.04802393,-0.012966146,-0.038179938,0.10436682,0.09980176,-0.031117631,0.072585054,0.03562538,-0.10688112,-0.12054608,-0.054514747,-0.039506733,-0.05524931,0.06270959,-0.075606994,0.022747526,0.0635247,-0.00066080474,-0.034462776,0.041145068,-0.0060234442,0.05110113,-0.075770974,-0.015770799,-0.00012138923,0.04175286,-0.02248159,-0.006731015,0.028412877,0.019974414,0.0024014958,-0.0394503,0.020575276,0.07335979,-0.024042275,-0.04894823,0.016705867,0.0021045587,-0.024071747,0.093934245,0.10080509,-0.0277557,0.09005943,0.04962005,-0.024432268,0.09026063,-0.04048979,0.010569692,-0.00038472255,0.04614583,0.0028744615,-0.03724042,0.0322829,0.020010948,0.0053116526,-0.060060933,0.0056679174,-0.04694811,-0.061804775,-0.0017608687,-0.06343602,0.0056888047,0.056807976,-0.03243004,0.08484401,-0.005394861,0.059826255,-0.05440076,0.06139909,0.099728584,-3.4449606e-08,0.02534032,0.022839343,0.011408586,-0.004065685,0.064933494,-0.023622876,0.005473916,0.06583685,0.050174005,0.016108938,0.017944727,0.034522846,0.039288953,-0.053202067,0.07111528,0.02195552,-0.018079504,-0.100109406,0.02357009,-0.034779195,-0.023516096,0.00014730441,0.034075856,0.01579461,-0.06768161,-0.04791622,-0.0066978703,0.0032183463,-0.004797449,-0.0076738326,-0.037499133,0.026336819,-0.022124706,-0.14644076,-0.07764156,0.009057707,-0.039847724,-0.069215484,0.050349455,-0.0051944577,0.0013832911,-0.08179932,-0.008195466,-0.006054991,0.02442622,0.029712096,-0.04021656,0.020234391,-0.044004165,-0.07456404,0.028076522,-0.07377263,0.027352292,-0.025634682,-0.0037332608,0.069516204,-0.006300797,0.010124635,-0.052536312,-0.037200175,-0.0832761,-0.05360141,0.13582917,-0.003094905 +3.2.1.179,"The enzyme releases 4-deoxy-4(5)-unsaturated D-glucuronic acid from oligosaccharides produced by polysaccharide lyases, e.g. the tetrasaccharide beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp produced by EC 4.2.2.25, gellan lyase. The enzyme can also hydrolyse unsaturated chondroitin and hyaluronate disaccharides (beta-D-4-deoxy-Delta4-GlcAp-(1->3)-D-GalNAc, beta-D-4-deoxy-Delta4-GlcAp-(1->3)-D-GalNAc6S, beta-D-4-deoxy-Delta4-GlcAp2S-(1->3)-D-GalNAc, beta-D-4-deoxy-Delta4-GlcAp-(1->3)-D-GlcNAc), preferring the unsulfated disaccharides to the sulfated disaccharides.",384,1.0,-0.056313455,-0.091844045,-0.03283838,0.0023888592,0.012527496,0.06408002,-0.04849766,0.015673622,0.03996534,0.1083896,0.058963317,0.04285231,-0.030406518,-0.020273136,-0.059655316,0.009869449,0.0037446008,0.013217998,-0.0457057,-0.06446293,0.05462828,-0.047070377,-0.0769702,0.024476875,0.024020229,-0.062062297,0.046824347,-0.0733317,-0.061796132,-0.08534433,-0.052213818,-0.08073458,-0.008855242,-0.024454264,-0.038163003,0.07964444,-0.06318233,-0.04311386,0.038038615,0.015435016,-0.0321225,-0.017305525,0.01230958,-0.043325175,0.0040732883,-0.06946583,-0.001530352,0.049714528,0.004246824,0.0135366,0.0003476101,-0.015455349,-0.046683047,0.013032141,0.015513757,0.007676813,-0.08503539,-0.037257563,0.012666778,0.15564863,0.047908492,0.09058053,-0.015576747,-0.040929906,-0.11663061,-0.03968726,0.067302205,-0.02426705,0.0059736297,-0.00083795236,-0.058044177,-0.02065391,0.014497951,-0.0068582892,0.05912021,-0.007819257,0.0072580096,-0.05402756,0.058209658,0.017482556,0.05720182,0.053746525,0.009431223,0.061227128,-0.02340566,-0.00838802,-0.029215055,0.019799758,0.069804735,-0.017447278,0.02490607,0.0057002855,-0.09167488,0.010884579,-0.020348866,-0.05633993,0.018073216,0.03323861,0.05084777,-0.003731046,-0.008651431,0.015078091,0.032047328,-0.15658623,-0.008713888,0.016498297,0.042713173,0.07156993,0.074025996,0.08105501,0.005465906,0.012282239,-0.016705828,-0.026468309,-0.08128273,0.14183162,0.008079204,-0.051117007,-0.03283273,-1.2264437e-06,0.0352215,-0.005274882,0.14783931,-0.012177741,-0.03581006,-0.0032491747,-0.0013662571,1.3013784e-33,0.068913065,0.027568405,0.026863623,0.06857648,0.010491864,0.006137549,-0.057431795,-0.018935867,-0.01000839,0.027898602,-0.09535733,0.021249667,-0.03136066,0.07645812,0.026000343,0.07477903,0.020344995,-0.064736076,0.044494558,0.017333327,-0.002253289,0.06881369,-0.038287994,0.0073405174,0.044838388,0.005605455,-0.012340956,0.026978968,0.06967669,0.0043187197,-0.015690403,-0.07003643,-0.05046916,-0.04303891,0.056104816,0.028215248,-0.13596681,-0.03138472,0.023468222,0.008482046,0.05872123,-0.009648037,0.008670279,-0.06892076,0.027610065,0.0185877,0.04419472,0.026056817,-0.025168696,0.059994683,0.088915326,0.027400969,0.06387116,0.026162025,-0.09488955,0.049150426,-0.06430345,-0.02188519,0.09472429,0.099809505,-0.0030751843,0.031365924,-0.028052427,-0.027247937,0.060568497,0.00024394046,-0.04043301,-0.016923806,-0.06398839,-0.06540522,-0.017851133,-0.12488043,0.011460266,-0.017410878,0.027295588,-0.052886326,0.018124972,0.058094308,0.010239234,-0.05407363,-0.02079235,0.08141828,0.016832178,0.0159251,0.03350577,0.026997129,-0.01419771,0.016574113,0.042361997,0.01579243,-0.042864367,-0.03328515,-0.012313647,0.054536067,0.00784608,-2.3835624e-33,0.042667974,-0.12379491,0.009764471,-0.024972182,0.018819582,0.04357157,0.101546064,-0.02435674,0.04217341,-0.048658658,0.0792007,-0.0356479,-0.020569438,-0.036257643,0.016152233,0.01784381,-0.067432955,0.06156674,-0.05839506,0.06291358,-0.0006117143,0.07043898,0.07717606,-0.057307668,0.11396709,-0.003282558,0.08014529,0.018263806,0.055987943,0.06418516,0.012214083,-0.042606197,-0.02576426,0.034400847,-0.10999259,-0.016914794,-0.09832221,-0.047688525,0.058764458,0.044954453,0.00873046,0.014728793,0.0077582966,-0.02510036,0.040237222,0.061326664,-0.06198833,0.016838755,-0.0019769368,-0.011093367,0.04852936,-0.032267466,-0.029966746,0.018239856,0.032809455,0.07303648,0.0250513,0.06739933,0.046393607,-0.033164863,-0.081278935,-0.05345766,0.079068854,-0.025494229,0.060694046,0.06527098,0.008474633,-0.028796349,-0.013843395,-0.041470107,0.010201033,-0.044355787,-0.06280896,-0.010838846,0.04187607,0.010222203,-0.12609,-0.055764854,-0.032266244,-0.071322605,0.009891968,-0.055799756,0.031131433,0.0037491636,0.033823885,-0.071179904,0.066149235,0.08744066,0.05908646,0.07887221,0.003953333,0.01828186,0.0061303996,0.073582694,0.13147886,-4.841427e-08,0.023815725,-0.002038002,-0.03805427,-0.054312356,-0.047060266,-0.034142856,0.027393427,-0.0052990657,-0.009549813,-0.012676183,0.015927514,0.12281525,-0.086645894,0.026634276,-0.04134549,0.05937849,-0.02524892,0.06545339,-0.011452418,0.0043594646,-0.04074594,-0.013877956,-0.055588644,0.014375413,-0.026435241,-0.07690012,0.035770312,0.014110067,-0.040631518,-0.041178524,0.026490793,0.054259002,-0.03550842,-0.13271198,-0.033047844,0.011705501,-0.066436574,0.006799389,0.00092709286,0.039527602,0.0024243547,-0.0028481593,0.012312137,0.018615605,-0.046950623,-0.03377453,-0.018540295,0.09655985,-0.03113135,0.085268036,-0.014799809,-0.027734818,-0.07337135,-0.11687032,-0.070919536,-0.040662985,0.010917427,-0.025085175,-0.012800015,-0.0539062,-0.07325016,-0.0055363355,0.117889225,-0.014880709 +3.2.1.180,"The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. It prefers the sulfated disaccharides to the unsulfated disaccharides.",384,1.0,-0.073413774,-0.07389976,-0.06825007,0.015310767,0.029973721,0.0021484466,-0.06354976,0.016258355,0.042035483,0.03691422,0.030030087,0.048252113,-0.044317655,-0.0010425542,-0.080643475,0.04673795,-0.01103277,-0.018527394,-0.06395276,-0.04329279,0.060115676,-0.044072893,-0.042141356,-0.030896623,0.08720736,-0.0016533373,0.03833539,-0.027472708,-0.021702422,-0.0453783,-0.030004539,-0.06471464,0.0055905017,-0.023801142,-0.0124239605,0.1082256,-0.056819763,-0.016932301,0.024138795,-0.008663969,0.040808786,-0.014894322,0.007236544,0.003915326,-0.056203708,-0.062387843,-0.050307836,0.052122924,0.046939213,0.03629713,-0.021176022,0.01832119,-0.016374309,-0.008413256,0.033580896,-0.005721587,-0.072043814,-0.0037911427,-0.013529646,0.09742206,0.053683747,0.047553968,0.005392145,-0.03278513,-0.06545374,-0.0689316,0.043541282,-0.05706404,-0.035027638,-0.016329149,-0.041744117,0.029307194,0.03977353,-0.040949866,0.04384718,0.033932168,-0.048242576,-0.05758142,0.08922891,-0.030211627,0.057555754,0.08152088,0.027269796,0.14371543,0.01180296,-0.0018828004,0.017483043,-0.024350319,0.017142342,-0.021596147,-0.012228682,-0.01605429,-0.09141173,-0.0024761823,-0.06996728,-0.04503867,0.024745034,0.035202913,-0.011931977,0.01481419,-0.015048162,-0.00027450395,-0.032821935,-0.1367754,-0.10303033,-0.015959663,0.011915267,0.057025004,0.091705,0.026619332,0.015495763,0.035807945,0.010426559,0.02566482,-0.062501736,0.09155899,0.042603575,-0.044323225,-0.044499185,-0.020936858,-0.01249192,-0.02812035,0.13099411,0.025628807,-0.07174846,-0.03326699,0.0037033213,5.7777906e-33,0.08545743,-0.0038295984,-0.01634367,0.026246063,0.018208751,-0.018143743,-0.10171071,0.01980314,-0.0071112826,0.027783701,-0.0994031,-0.0485408,0.0034668818,0.075221814,-0.054086413,0.011135572,0.018984698,-0.05298888,0.07191673,0.015635423,0.039968863,0.101289995,-0.040043816,0.069074586,0.06603516,0.029117327,-0.035928722,0.04028118,0.075758025,0.027248539,0.001796223,-0.11097996,-0.045165423,-0.06859543,-0.025803654,0.0885615,-0.14786506,0.0078107486,-0.025911156,-0.011621442,0.052336607,-0.014112022,-0.0028771476,-0.07387742,0.041968122,-0.014990185,0.053255245,0.02019757,-0.029234687,0.062029794,0.052656565,-0.037318546,0.09810241,-0.004903738,-0.12448178,0.010066041,-0.014174214,-0.03277883,0.05944707,0.10445882,0.002113288,0.0368479,-0.060093697,-0.026929213,0.022682784,-0.014635312,-0.030007094,-0.025352847,-0.059192166,-0.008217479,-0.043361682,-0.038810056,-0.0151465,0.020767618,-0.026808359,-0.029479109,-0.0034638804,0.057493627,0.061340436,-0.039260168,0.009419043,0.0088957725,0.029809667,-0.013308569,-0.04952138,0.06190077,-0.0547872,-0.02854292,0.03635125,0.026974892,-0.052564237,-0.08400439,-0.013873252,0.001439901,0.021238906,-7.816904e-33,0.03510301,-0.08500018,0.02139582,-0.0155181615,0.012401543,0.07314117,0.054286253,0.051269423,0.042690657,-0.022374243,0.08254351,-0.032676723,-0.008191763,-0.015526376,0.07049877,0.05508013,-0.068930164,0.05017296,-0.04991051,0.04761974,-0.010597544,0.102536984,0.06892272,-0.03822213,0.11864311,0.010122009,0.06742014,0.013382843,0.026632266,0.08449356,-0.016446663,-0.039233364,-0.06848927,0.008643724,-0.065632574,0.016197331,-0.12587632,-0.05266464,-0.012533688,0.035077162,-0.027767723,0.007513586,0.054990172,0.08746102,0.033625428,0.063825086,-0.09154698,0.050811384,0.042414047,-0.006171366,0.020984627,0.0065236134,-0.02037801,0.020653205,0.024671385,0.109570675,0.055769406,0.025941512,-0.054350276,-0.017576719,-0.12528501,-0.044590894,0.041069373,-0.018355269,0.018149989,0.04340397,-0.02566305,-0.015698291,-0.020593166,-0.058160495,0.030797357,-0.018313406,-0.00980932,0.024112884,0.016696075,-0.023820035,-0.13094507,-0.007191366,-0.017482799,0.008211882,-0.015699401,-0.023236869,-0.006593864,-0.064127505,0.042441484,-0.034531947,0.06358621,0.09434266,0.0451928,0.09146493,0.0008782586,0.06532006,-0.030467723,0.0090111615,0.054235764,-4.6455018e-08,0.024926608,-0.044146895,0.016240247,-0.057152707,-0.056771927,-0.036810122,0.02174463,0.0213065,-0.030034784,-0.008741038,0.05431324,0.117970206,-0.10407186,0.0075255586,-0.04408015,0.024464026,-0.016539948,0.03456844,0.0044239243,-0.007369742,-0.08821693,-0.071185954,-0.054477923,0.018791175,0.023111902,-0.111106835,-0.0032256765,-0.028506214,-0.05531992,-0.008007851,0.05972114,0.07947721,-0.07152975,-0.080196545,-0.061032116,0.03386627,-0.06378545,-0.0028723914,0.010801106,0.03462544,0.013534409,0.03301057,-0.011161277,0.02518356,-0.040745795,0.0070535545,-0.027221575,0.052937478,-0.01016453,0.08369979,-0.06558717,-0.042133085,-0.050433856,-0.07219027,-0.040359903,-0.034550373,0.01283719,-0.057233337,-0.00408419,-0.05318827,-0.07047733,0.044666495,0.17187138,-0.029644666 +3.4.19.13,"This is a bifunctional protein that also has the activity of EC 2.3.2.2, gamma-glutamyltransferase. The enzyme binds its substrate by forming an initial gamma-glutamyl-enzyme intermediate, releasing the L-cysteinylglycine part of the molecule. The enzyme then reacts with either a water molecule or a different acceptor substrate (usually an L-amino acid or a dipeptide) to form L-glutamate or a product containing a new gamma-glutamyl isopeptide bond, respectively. The enzyme acts on glutathione, glutathione-S-conjugates, and, at a lower level, on other substrates with an N-terminal L-gamma-glutamyl residue. It plays a crucial part in the glutathione-mediated xenobiotic detoxification pathway. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide.",384,0.99999994,-0.032564,-0.09926999,-0.0459177,-0.023893334,0.09069485,0.04189193,0.019176932,0.07095425,0.03333513,-0.0481731,0.09504373,-0.02371379,0.017951414,0.024733258,-0.00797929,0.05628306,-0.050003957,-0.06643469,-0.06033162,-0.076629385,0.056223515,0.040871035,-0.06784654,-0.01796555,0.021579284,0.03491041,0.086240575,-0.07646378,0.016654355,-0.027929211,-0.015421774,-0.118671045,-0.011658862,0.0075445445,0.014230966,0.08453353,-0.058968358,-0.08433983,0.067045465,-0.018032823,0.018875327,0.01697587,-0.017460437,-0.08838454,0.021807117,-0.03515795,0.03268902,-0.0019873457,0.011088711,-0.015281163,0.03497234,-0.064725675,0.013543329,0.053224903,0.026246272,0.034944035,-0.09296485,-0.044385836,-0.047322374,0.09679299,-0.010695373,0.019216036,-0.012537425,-0.08522017,0.06882146,-0.056016043,0.038135134,-0.05865734,0.0117562115,-0.053156953,-0.08265013,-0.04022843,-0.0021246688,-0.0015004413,-0.009533709,-0.031605367,0.013905147,0.039099414,0.0407049,-0.046824466,0.04603196,-0.056397174,0.049373776,0.084775016,0.024783375,-0.06407512,-0.015698493,0.07252696,0.055936653,0.038759384,0.0005612581,-0.018189728,-0.009587047,-0.016691672,-0.036850706,0.03989266,0.0053079925,0.03623719,0.02408018,0.025080152,0.004341284,0.113167554,-0.010816915,-0.06499674,-0.042104684,-0.00986278,0.006282746,0.073451616,-0.020500718,-0.057405755,0.045084283,-0.027081398,0.019118251,0.044274796,-0.041140433,0.11558696,0.07639676,-0.042577554,-0.06014001,-0.0076146233,0.05494564,0.016362755,0.029048147,0.032879084,-0.013052784,0.083578065,-0.076723,1.6020026e-33,0.063779704,0.056759153,-0.0018241402,0.029818557,0.016350199,0.03701883,-0.097254254,0.036400292,0.026715701,-0.02414443,-0.0669011,-0.061024606,0.0071329363,0.017083813,-0.03301756,-0.04779426,-0.06529922,-0.017507838,0.07862099,-0.003753414,0.02889712,-0.0048262305,-0.018508367,0.0022673584,0.010824564,0.0628186,-0.008998678,0.0047330526,-0.0011094224,0.014089331,-0.04988055,-0.06714694,-0.0759938,0.036686637,0.04665684,-0.020139217,-0.019997176,-0.05669453,0.0440207,0.036268845,0.01744732,0.024979578,-0.02908694,-0.034515183,0.023421777,-0.063283466,-0.015680522,0.04118317,0.0128245875,0.07030294,0.059000857,-0.10096268,0.10946926,-0.012057871,-0.058880147,0.020568607,-0.024138387,-0.07240294,0.019297773,0.046208102,-0.004202791,0.057083193,-0.0660895,0.040644806,0.029140437,0.052636422,-0.05123768,-0.030872613,-0.0014221232,0.06633236,-0.076385744,-0.042734686,0.0796632,0.043474376,0.023733879,-0.05592969,-0.12756833,0.06483632,0.016378159,0.04194969,-0.04366202,0.016743042,-0.0013135546,-0.009700146,-0.053815715,-0.034191806,0.03450692,-0.062245373,0.01098859,-0.007898914,0.0034075258,-0.026324095,-0.00078904635,0.040775374,0.017628003,-2.3724035e-33,0.071528204,-0.1140867,0.0052457494,-0.06524119,0.01944654,0.024447445,0.023772111,-0.0216767,0.07767655,-0.0090594115,0.033262014,0.03480051,0.014609402,-0.021259721,0.021167038,-0.017598594,-0.034919634,0.12270789,-0.053912513,-0.05735243,0.048526295,0.02562961,0.08404618,0.083430246,0.044434935,0.00582546,0.018091975,0.0059859664,0.07684668,0.09423273,-0.073585436,0.012028028,0.026296314,-0.08202701,0.014617968,0.028550949,-0.014593003,0.011816087,0.022157874,0.015554619,0.032121137,0.07375889,0.017213019,0.062829174,0.01357863,0.16216062,-0.023143396,-0.020778049,-0.0989087,-0.07237692,0.027889859,-0.02318378,-0.024094252,0.044441354,0.020681493,0.039337654,-0.04472618,-0.0016868894,-0.014741195,0.046747386,-0.030102631,-0.08474489,-0.044599388,0.0014259225,0.03288699,-0.039811816,0.010299378,0.030637402,-0.005289898,0.027619822,0.046495527,-0.11537505,0.043895975,0.040693525,-0.029752873,-0.016233383,-0.11481155,-0.03185447,0.03353282,-0.09287586,0.05869245,-0.040744904,0.0019175408,-0.07538929,0.022826497,-0.069657035,-0.028168144,0.18336721,0.033166405,-0.016068984,-0.05743666,-0.0029488944,-0.04711823,0.06619472,0.061550777,-4.7025157e-08,-0.019125672,-0.043846045,0.017031344,-0.017530704,-0.0031009421,0.06512732,-0.0009982674,0.04291605,0.055826023,-0.02632,-0.01052142,0.08088769,-0.060134485,-0.014343361,-0.071526654,0.051096253,0.018010203,0.06969012,-0.007467382,0.035970423,-0.08459219,-0.06509871,-0.052576575,-0.047209773,0.017671721,-0.095740125,-0.009687097,0.09223122,-0.00082842575,-0.05857047,0.01104181,0.038435325,0.01583459,-0.030612502,-0.14218165,0.027571367,0.007277349,-0.037224285,0.04751684,0.020430949,-0.008620412,0.03568511,-0.10904737,-0.008306336,-0.010268817,0.04489956,0.0037756404,0.0042237747,-0.04274331,0.029540693,0.032998774,-0.07088895,0.034514084,-0.05104017,-0.10030128,-0.02199524,-0.03662355,-0.045605503,0.057801567,-0.068795666,0.025260944,0.07000982,0.14364873,0.0150588155 +3.5.1.109,The enzyme is involved in the sphingolipid metabolism in the epidermis. ,384,0.99999994,-0.055006944,-0.04684842,-0.066210814,0.019029552,0.06650262,0.017821537,0.062676474,0.053507533,-0.02662023,0.0012799058,0.070904985,-0.08650523,-0.10859059,0.03439516,-0.018255977,0.02451753,-0.07995444,-0.048140716,0.04787182,-0.09005853,0.064686775,-0.0049627307,0.0045684753,0.036442146,-0.0044485047,-0.043901067,0.035826445,-0.026084628,-0.044420872,-0.0011884213,-0.0033437293,-0.034838997,-0.005678743,-0.058631536,-0.027610833,0.07699009,-0.058144707,0.020443955,0.042634927,-0.0019297743,0.06172369,-0.03852485,-0.077611394,-0.025067467,-0.004285063,-0.05348395,0.018704174,0.043955564,-0.011189311,0.05455803,-0.0065492573,-0.08704048,-0.00781269,-0.0341412,-0.05543732,0.022487205,-0.100420326,0.011273132,-0.10396614,0.034422692,-0.030342985,-0.04279479,-0.026982455,0.027317248,0.011950609,-0.110461526,0.087127045,-0.07273757,-0.009326904,-0.02762227,-0.02164559,-0.09694822,0.0027086856,0.029027287,0.026769595,0.002116952,-0.009775332,0.016226385,-0.0036941203,-0.018621387,0.05638967,-0.012673506,0.017828198,0.09087862,0.032269746,0.027473839,-0.0068998947,0.0035549495,-0.031859145,0.026182193,0.06092821,-0.041551653,-0.052539874,0.03611174,-0.06758554,0.09461444,-0.036772158,0.0062468643,0.00077001867,-0.015491316,-0.05190794,0.0007891898,0.012999258,-0.037924256,-0.023304896,0.00082188466,-0.02796289,0.053618874,-0.041719746,0.019155215,0.0825684,0.016968636,0.04616446,0.037573054,0.012542007,0.022044819,-0.033634122,-0.032811392,-0.004076862,0.017011821,-0.017983573,0.07172435,-0.0214671,0.036160175,-0.057404447,0.024657186,-0.00678379,-4.0067562e-33,0.028947376,0.044983514,0.018650457,-0.0809949,-0.065399796,0.01864787,-0.03216029,-0.023714397,-0.058859468,0.0057023815,-0.035250105,-0.08704821,0.018341433,0.080297336,0.01594302,0.039768744,-0.012426355,0.049756546,0.1310127,-0.066972695,-0.013967887,-0.007763529,-0.08204845,-0.061465114,-0.031172575,0.11568364,-0.14178042,0.009107017,0.0666534,-0.008173335,0.032974564,-0.009177764,-0.063031524,0.018871758,0.06242071,0.03897543,0.031807758,-0.014749399,-0.027649818,-0.010343585,0.026347378,-0.012716181,0.017402576,-0.038648445,-0.034553234,-0.007367002,-0.060146227,0.0636291,0.08060484,0.03475443,0.06333874,-0.03968464,0.1724431,0.036506142,0.018214721,0.04633678,-0.0067226705,-0.013253068,-0.01065519,0.042848103,0.010319905,0.07787567,-0.01553753,0.053112525,0.042264193,0.0031005242,-0.07372213,-0.04306756,-0.11404216,0.058391623,-0.038477186,0.03412433,0.105526336,-0.017066251,-0.019919667,-0.03162784,-0.009474081,0.046045847,-0.03862349,0.034213275,-0.008332109,-0.019597627,0.00896921,-0.039036676,-0.013087861,0.026068488,-0.017767709,0.042203456,0.028516665,-0.035268933,0.011108328,-0.01223603,-0.078446336,0.045891494,-0.064864576,6.6208516e-34,0.04355222,-0.05431311,0.042887025,-0.08216719,-0.054304924,0.090997346,0.064436026,0.054296095,0.020443274,0.03146828,-0.006806442,-0.009438627,-0.05460769,-0.06610884,-0.006522044,0.053660903,-0.039242256,0.065595895,0.038884398,-0.07085406,-0.04501999,0.09851615,-0.02168842,0.09215434,-0.016892727,-0.014794537,0.04612637,0.031840976,-0.03815492,0.00011095273,0.022087768,-0.11335743,-0.056632664,-0.041149776,0.011820108,0.00035782912,-0.064035274,-0.006759261,0.013371522,-0.008910568,-0.04962412,-0.051004156,0.057392295,0.07169641,0.12501639,0.06854552,-0.11811423,0.043146506,-0.0671076,-0.061137278,-0.0011334433,0.060606368,0.06568222,-0.0053127618,0.048385732,0.045760784,-0.022924528,-0.014576267,0.071834534,-0.07844177,-0.013377034,-0.07910353,-0.06073901,0.07112903,0.022028625,0.031480774,-0.048013955,-0.011385519,-0.014691006,0.0075398707,0.01789504,-0.007065504,-0.08608146,-0.0064045326,-0.07015213,0.002796736,-0.07695241,-0.054484256,0.014510517,0.034785252,0.014972766,0.014380841,0.007709875,-0.037437465,0.011474769,-0.023826228,-0.05832723,0.05708072,0.024485953,-0.0047344603,-0.005679527,-0.0096104,-0.024462096,-0.02143652,0.025985662,-2.1674921e-08,0.1277613,-0.049591504,0.054458074,-0.08826047,-0.057840515,0.013779276,0.06755221,-0.0021289114,0.04654916,0.0008916871,-0.09714027,0.036043204,0.04699316,0.12256464,0.06173693,0.039659873,0.073291816,0.030913442,-0.05983366,-0.11906387,-0.061316054,-0.023617186,-0.023975346,0.013929497,0.047320567,-0.038111858,0.0788641,0.10888259,-0.08714844,0.07974533,-0.015464003,-0.021386638,7.977178e-05,0.07753315,0.022899421,0.023087798,0.016384348,-0.046932302,-0.030686196,0.08786447,-0.017761823,-0.066443294,-0.014506892,-0.02597345,-0.024134496,0.007103077,0.07199941,0.0006446807,0.09682832,0.025224283,0.0037637583,-0.012802839,-0.07217225,-0.0024609468,-0.1081931,-0.026738359,-0.018429695,-0.0106715355,-0.010433735,-0.040384404,0.05753552,0.070012495,0.15346265,0.0064540985 +3.6.1.55,"This enzyme hydrolyses the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC 3.6.1.56, 2-hydroxy-dATP diphosphatase) [4]. Requires Mg2+.",384,1.0,-0.079066664,-0.027339911,-0.010219363,-0.04988532,0.016425714,-0.078248516,-0.006508901,0.018059002,-0.079881266,-0.047475327,0.010554321,0.048949264,-0.036047913,0.026803121,-0.08330823,0.04646617,-0.05349611,0.03069268,0.06533222,0.004342385,0.04635513,0.011292695,-0.01673246,0.04947525,0.033923946,0.10387787,0.09252372,0.012630634,-0.0047158664,-0.05930733,-0.014332116,-0.016427448,-0.018748358,-0.088699296,0.07034419,0.14496744,0.014128913,-0.016733998,-0.01772617,0.0003447049,0.058299612,-0.030060597,0.0005031222,0.0039801137,-0.021934975,-0.045034215,0.021225708,0.02738308,0.031134605,0.057093393,-0.03359887,-0.030447176,0.008447487,0.00045777642,-0.008005285,0.013993983,-0.09527294,0.043281447,-0.023959178,0.053279635,-0.03814115,0.04945089,-0.024614321,0.029974446,0.08607921,-0.049762603,0.040821414,-0.05373901,-0.025444496,0.00069148396,-0.028247444,-0.033137113,0.008920808,0.012952513,-0.058615305,0.030241653,-0.0045102984,-0.07870647,0.11038733,-0.025554014,-0.014346813,-0.019516548,0.002233818,0.0673246,0.03193777,-0.01853852,-0.022643931,0.050601423,0.035745237,0.047902286,0.021632943,0.026739212,0.030424876,-0.008969465,-0.02197812,0.07435616,-0.04196986,0.050362054,-0.046754625,-0.015312847,0.002796332,0.11846363,-0.07717671,-0.07838178,0.0045987843,0.012370314,0.007457323,-0.032668922,0.034563843,0.034129243,-0.017849596,0.02962988,-0.0017031942,0.0012909258,-0.03264468,0.08875583,-0.085542545,-0.043838203,-0.058233384,-0.07276797,0.000804891,-0.073028855,-0.020579366,0.06940773,-0.05540031,-0.0054596313,-0.03527648,3.768621e-33,0.0427654,0.04375835,0.001636822,-0.0123007605,-0.048449356,0.020556455,-0.08541979,0.014551777,-0.09185312,0.0039292574,-0.0130862985,-0.09360758,0.02546517,0.015183528,0.002843707,-0.05197434,-0.011471305,0.080406316,0.10080603,0.014232217,0.0012630753,0.076361105,-0.041840192,-0.007816943,0.031612936,0.06874517,-0.07681592,0.018180937,0.13260518,0.021230811,0.053736646,-0.12474979,-0.107781775,0.0056996644,0.015830161,-0.061000627,-0.06556397,-0.08437953,-0.0035236825,0.09495452,-0.046302177,-0.02208547,-0.016006295,-0.015264913,0.034413695,-0.055945955,0.033184703,-0.006442455,0.0071818507,0.020479832,0.031008504,-0.023747478,0.022137336,-0.04020572,-0.06580257,-0.03117033,-0.024557875,-0.023435965,0.050684273,0.06420612,0.008690236,0.024156472,-0.027878836,-0.0405659,0.018004283,0.012319814,-0.014107683,-0.06338583,0.020960944,0.060403094,-0.0031034783,-0.050684348,0.01622831,0.007084235,-0.0070289094,-0.041470446,0.04713557,0.044599146,0.03735206,0.03301595,0.014483634,-0.04777282,0.0007876914,0.015381476,-0.03315163,0.03915556,0.060961984,-0.014438547,0.010201576,0.035244893,0.11425884,-0.07410203,-0.02721569,-0.05575374,-0.0016401109,-4.6378164e-33,0.06742049,-0.07398096,0.030023238,-0.09402141,-0.06742712,-0.045856357,0.111446045,-0.019173115,0.0742107,-0.02473177,0.05121947,-0.059650972,0.007641618,-0.118504845,-0.00010565208,0.02583692,0.02488294,0.078605324,-0.048215114,-0.020781165,0.077401936,0.11726755,0.07683633,0.108527854,0.028208306,-0.0068379813,-0.009292919,0.034673024,0.069847256,0.08778196,-0.086021416,0.074197836,-0.077788,-0.034522306,-0.02586975,0.07101416,-0.04399624,0.01746845,-0.003202783,-0.028370118,-0.008790193,0.07297878,-0.014612474,0.06278149,0.016284015,0.09297421,-0.044177927,0.09732147,0.0051495912,-0.03551282,-0.00050294225,0.03786485,-0.020035403,0.03254825,0.038241874,-0.02762669,-0.05587837,-0.0022240526,0.014826623,-0.05608995,-0.010193533,-0.07092247,-0.03640571,-0.017493876,0.04001609,0.08171487,-0.032620937,-0.0015194857,-0.0062959357,0.039959535,0.029056996,-0.03423756,0.070315994,0.040079556,0.0047386074,0.024694256,-0.058690924,-0.02589838,0.033012003,-0.067778,0.035914823,0.040541843,-0.016052464,-0.053900257,0.080780394,-0.065112986,-0.010941534,0.10401025,0.013819854,0.03657621,-0.01607836,-0.025353694,-0.057708006,0.07532302,0.053208575,-4.2834692e-08,0.017210312,-0.14199054,0.08133277,-0.086389795,0.033350095,0.03692882,-0.015854677,-0.00017783054,0.09829061,-0.038743507,-0.008532485,0.03745882,0.012161548,-0.030408606,0.0035559644,0.010726607,-0.014349353,0.048140515,-0.04796788,-0.03431537,-0.06417042,-0.0075535495,-0.11735456,0.07699737,-0.004754264,0.047818128,0.024402566,-0.0028417208,0.009175409,-0.06300121,0.035806555,0.036294002,0.008300107,-0.06749499,-0.020034295,0.05222996,-0.0078008925,0.044072006,-0.07935732,-0.03298148,-0.0781815,-0.040793173,0.012254487,0.011503537,0.0038169287,0.002996349,-0.0058608134,0.044210773,-0.015334248,-0.033587445,0.06689006,-0.073292345,-0.02073389,-0.12576777,-0.05769372,-0.06367153,-0.022907063,-0.07636452,-0.044649407,-0.07678615,0.0065265293,0.056780297,0.18224317,-0.067881435 +3.6.1.56,"The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [3].",384,1.0,-0.10787286,-0.0304794,0.017771432,-0.06230767,0.04161828,-0.050143648,-0.022322822,0.08799887,-0.023264328,-0.0520424,-0.031858128,0.059057552,-0.0995333,0.049023457,-0.0791899,0.077283196,-0.06335807,0.029351931,0.089313515,-0.049509823,0.02456221,-0.016287386,-0.00804621,0.049139544,0.031943712,0.05912948,0.07272332,0.07722206,-0.026250845,-0.08414704,-0.03853595,0.024716726,-0.051246513,-0.061598387,0.055027515,0.09874388,0.045180086,-0.004388245,-0.004554578,-0.020257246,0.09144622,0.012723626,-0.03922008,0.034517623,-0.017762143,-0.020193445,0.0073780017,0.092347376,-0.013115336,0.01583298,0.004033909,-0.014783914,0.02158223,0.03505057,-0.010780385,-0.015708778,-0.060045596,0.0056778705,-0.054572135,0.017744778,-0.05744816,0.024076616,0.017300395,-0.0002094449,0.102653846,-0.030928176,0.055831913,-0.022029897,-0.037029535,0.018996954,-0.025924968,-0.038843885,-0.017834513,0.056575414,-0.06829712,0.009598177,-0.005022376,-0.10205161,0.1187613,-0.053379253,-0.009870157,0.021379739,0.01338096,0.06561087,0.059384838,-0.014811882,-0.029039504,0.012036873,0.0073568407,0.0066088266,-0.019472819,0.011206299,0.0010177613,-0.028227104,-0.024128659,0.06933044,0.01781371,0.05417517,-0.038200002,-0.025227448,0.032211658,0.06512385,-0.09919561,-0.041170668,0.0030333102,-0.010609754,0.027793495,-0.0044641388,0.027715132,-0.007486318,-0.016259994,0.07972803,0.0037932654,0.0037827268,-0.066587076,0.05584073,-0.08654873,-0.018380692,-0.057790037,-0.057671063,-0.06344276,-0.057931714,-0.018780736,0.0922079,-0.023438642,0.013360575,-0.0104090925,2.4284082e-33,0.040547516,0.034611836,-0.018964097,0.013816672,-0.015693163,0.013297464,-0.083431534,0.02358724,-0.06236006,0.048872698,-0.045378134,-0.10745001,0.04859923,0.006889498,0.038139816,-0.037418608,0.002074695,0.10072595,0.05624421,-0.051598858,0.011441218,0.043406375,-0.03202618,-0.012749924,0.019942876,0.09038405,-0.09988971,0.03368069,0.10412324,0.004766179,0.03202083,-0.10429647,-0.061457388,0.029922051,0.020565558,-0.074634105,-0.03236223,-0.08347004,0.037923582,0.10878679,0.003012419,-0.010705295,-0.0016107834,-0.049182314,0.0379468,-0.035287417,-0.011924187,-0.0010861732,-0.0141635835,0.036423378,0.02136512,-0.011864042,0.044471957,-0.07706674,-0.025312722,-0.027562596,-0.03868648,-0.04731966,0.08140777,0.08499652,0.021514911,0.03282429,-0.036774684,-0.037018068,0.019802421,0.01570875,-0.030707851,-0.07140334,0.054653488,0.114980586,-0.022142464,-0.021543013,0.007642954,-0.019234702,0.024080092,-0.040801343,0.004557,0.06822577,0.060519185,0.046234053,0.024289718,-0.051243827,-0.035443056,-0.0029266963,-0.012390427,0.011956727,0.030944094,-0.03938528,-0.020565698,0.036514364,0.12833048,-0.06641597,-0.017009439,-0.108333506,0.011250436,-3.4365214e-33,0.022333346,-0.047457315,0.014637842,-0.09750796,-0.04196045,-0.033882122,0.05380921,-0.04777913,0.080992274,-0.023214536,0.08688632,-0.04427839,-0.04253514,-0.08894005,0.004897372,0.052438468,-0.016252311,0.08150212,-0.007836955,-0.03173975,0.051033467,0.09977626,0.038757898,0.12876914,0.056126416,-0.025908213,-0.025403932,0.02107629,0.09611201,0.039213322,-0.059820503,0.08143629,-0.059687335,0.045664504,0.031103367,0.026811996,-0.084334254,0.06993599,-0.011747643,0.009279892,-0.011006086,0.060454115,-0.041101553,0.0683751,-0.014322984,0.08989791,-0.07647885,0.10144967,0.020515643,-0.0020006334,0.016217414,0.0068127075,-0.012357199,0.0024045024,0.019941308,-0.027817741,-0.040763754,-0.010081701,-0.00063755945,0.005911749,-0.00669826,-0.06952099,-0.037979826,0.018416874,0.0077266297,0.09557476,-0.054526366,-0.0036714924,-0.019335374,0.0086569125,0.033115048,-0.011982891,0.039873995,-0.021549907,-0.042384427,-0.02989956,-0.0643713,-0.0026382313,0.03128364,-0.05424954,-0.011030797,-0.001329117,-0.009856929,-0.051329434,0.010367608,-0.005640929,-0.033068802,0.06862165,0.029504294,0.04001379,0.017008288,-0.034673356,-0.03950202,0.044521444,0.017882297,-4.3514355e-08,0.04212796,-0.12952672,0.086423405,-0.09971184,0.014221061,-0.014922418,-0.03625466,0.048894964,0.13086529,-0.032524537,0.028887993,0.07579272,0.0036714233,-0.039282337,0.06617477,-0.019280218,-0.011710913,0.045114413,-0.04406083,0.02704632,-0.046480983,0.016894085,-0.0884418,0.06648691,0.006181698,0.04308571,0.0024958937,-0.003776564,0.075114064,-0.039647933,0.0776838,0.04990967,0.011953755,-0.0335659,0.008848659,0.038418084,-0.011157127,0.034472417,-0.105782315,-0.010146246,-0.063921854,-0.07137539,-0.051518008,0.010074837,-0.015767312,-0.011423507,0.019888557,0.025705554,-0.001378826,-0.04183036,0.03462492,-0.048939753,-0.004537036,-0.101035275,-0.07732217,-0.04875838,-0.011626907,-0.08480742,-0.071456246,-0.06409692,0.009826521,0.06298689,0.20076615,-0.07243881 +3.6.1.57,The enzyme is involved in biosynthesis of pseudaminic acid. ,384,0.99999994,-0.10014194,-0.057284467,-0.19315535,-0.007906473,0.05501686,0.07169164,-0.09566418,0.057943296,0.054760568,0.006669978,0.0022396136,-0.018855818,-0.050864063,-0.028417071,-0.061140988,0.01886867,-0.051081445,0.0034803268,0.039265845,-0.057567872,0.016188271,0.006497416,-0.006010868,0.00017667878,0.042056154,0.081288755,0.053486045,0.014753449,-0.0051441225,0.00369241,0.0462225,-0.077214204,-0.00041354686,-0.047510184,0.03818033,0.04385539,-0.031588446,-0.060067452,0.0578209,-0.0028499428,0.07341791,-0.005992965,-0.13245003,-0.049614545,-0.025060283,-0.0219179,-0.09787028,-0.025546547,0.030821893,-0.0012480137,-0.011446817,-0.04735542,-0.026884818,-0.0014754013,-0.07680127,0.025795814,0.008220541,0.0080748815,-0.013080902,0.06495354,-0.009299192,-0.009921139,-0.075683154,0.017704153,0.05891015,-0.051078394,0.030031819,-0.02636192,0.047928452,-0.026727702,-0.063053824,-0.00020864431,0.07956544,-0.003730209,-0.034993626,0.036872253,-0.041339774,-0.04863013,-0.0453053,-0.016655777,0.06117049,0.025831072,-0.03267268,0.12303663,0.040532053,0.06619873,0.069420196,0.0014257242,0.07831106,0.10667695,0.009917944,-0.05419039,-0.034026153,0.00027741084,-0.059326574,0.04907494,-0.03275837,0.0292701,0.022125369,-0.058339205,-0.025702897,0.0774987,0.012543193,-0.14071171,-0.056512147,0.021527983,-0.07833077,0.04847307,0.06512385,0.0331386,-0.023341153,-0.024871666,-0.020054085,-0.00579315,-0.02219202,0.08761111,0.013251427,-0.067700565,-0.11750962,-0.057147667,0.04116274,-0.017020117,0.019688679,0.07051841,-0.018337809,-0.026818387,-0.06982451,-2.5430513e-33,0.066699564,0.0053771655,0.055403497,-0.031692605,-0.022807073,0.014238554,-0.10984582,0.02741912,-0.029757056,-0.049178682,-0.030756861,-0.09596577,0.027839566,-0.020806504,-0.029838547,0.02977177,0.0361167,-0.008539478,0.08393844,-0.0012588529,-0.009179665,0.027708419,-0.0074442704,0.017903876,-0.018021822,0.062409222,-0.067462154,0.055596165,0.026498605,0.012144515,-0.004416997,-0.07378107,-0.04763789,0.024847217,0.09478382,0.055455625,-0.044152405,-0.076506816,-0.0058087436,0.09619743,0.032735948,-0.022031402,-0.0014271127,0.019218113,0.010242518,-0.088124715,-0.03238727,0.059449982,0.010066295,0.07687702,-0.032441217,-0.0364277,0.10801675,0.04958806,-0.033098802,-0.022665499,-0.016575363,-0.044566467,0.021418484,0.030097924,0.011864128,0.009816327,-0.06680574,0.02369472,0.035912912,-0.043259393,-0.06653003,0.0420584,-0.005628114,0.009121988,-0.061344817,-0.01177486,0.05409947,0.005188537,0.06232446,-0.027070964,-0.012019431,0.07263927,-0.026583146,0.00885268,-0.060722563,-0.065151714,-0.07071334,0.013174644,-0.06169101,0.055074632,-0.002812206,0.00024295678,-0.06595199,-0.013765948,0.0013885525,-0.14283231,0.04406691,0.10786176,0.00029149777,-1.1340892e-33,0.060483664,-0.11925365,-0.0147567,-0.050297577,-0.016348172,0.06347497,0.022584124,0.03556864,-0.06980014,0.036867544,0.024605328,0.0093033,0.036766887,-0.0023894433,0.019405274,0.050636888,0.026173959,0.11090916,0.004741036,0.011858434,0.024369026,0.108071715,0.0014312085,0.039496254,0.026945168,0.01781599,0.08767765,0.015595772,-0.036100302,0.10096914,-0.048869975,0.020410825,-0.081845984,-0.005245836,-0.020171123,0.034694128,-0.00789961,-0.03283016,0.04144336,0.02723427,-0.03517704,0.046401143,-0.008641671,0.0034169783,0.08236871,0.05023422,-0.029482484,0.02769632,0.035034545,-0.024147345,0.04390594,0.07864136,-0.026664544,0.028501773,0.021805953,-0.046841297,-0.04040322,-0.032944564,0.029743245,-0.10602661,-0.019893028,-0.004163406,0.0031662295,0.028371535,-0.023270542,0.016714863,0.04733349,0.0854634,0.049364008,-0.043629743,0.03165991,0.017706376,0.0070075733,0.07007795,-0.059426185,-0.08708983,-0.08485822,-0.024801731,0.037814178,0.01772291,-0.03472077,0.023389742,-0.003932437,-0.11367123,0.01600182,-0.026635626,0.015777774,0.100520045,0.0014417969,-0.0017326035,-0.009574522,0.025575649,-0.012455752,0.0926647,0.04342779,-2.1764878e-08,0.043229785,-0.08245268,0.054625764,-0.049552497,0.035394963,-0.026087444,0.006823579,0.022418609,0.0014236962,0.0089649735,-0.016183892,0.079012744,0.01470337,0.05377564,-0.007900551,0.032876395,0.013012457,0.050396323,-0.019025866,-0.04569383,-0.06797893,-0.056221437,-0.051365796,0.011752375,0.04630337,-0.10263598,0.015722701,0.014493104,-0.06717048,-0.04676657,-0.03701837,-0.006296471,-0.04210684,-0.064127736,-0.006200746,0.077102296,0.09203518,-0.03436875,-0.015205426,0.006770015,-0.00978445,-0.048797637,-0.058173526,0.040503304,0.028175548,0.03311572,0.060079448,-0.011311019,-0.023180557,0.031091982,0.03673789,-0.0095467055,-0.0061625573,-0.07451382,-0.07921034,0.021119628,-0.020918814,-0.11468319,-0.07004312,-0.038521312,0.005629761,0.055818137,0.20299518,-0.024890149 +3.7.1.15,"A multifunctional enzyme which also forms (+)-beta-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-beta-caryophyllene synthase]. Three atoms of deuterium are incorporated into (+)-caryolan-1-ol in the presence of D2O. This is consistent with the proposed mechanism of formation.",384,0.99999994,-0.07013299,-0.07239755,-0.071681105,0.049203884,0.045642905,0.015658187,-0.030342748,0.033052903,3.6208214e-05,-0.04099945,-0.026229335,-0.0142749045,-0.12066368,-0.033714056,-0.019949466,-0.018902482,-0.12082903,0.038273085,0.019445961,0.044262562,-0.009292024,-0.00030066108,0.006493739,0.056760333,0.018395202,-0.0005038118,0.056278903,-0.022449544,-0.0064769057,-0.10111108,0.07699647,-0.009020662,0.0480225,-0.030202877,0.06241855,0.020164035,-0.032965824,-0.057740096,-0.053051803,0.029594993,0.07925363,0.01517103,-0.026601005,0.0126455,-0.022941254,-0.010140536,0.006653377,0.09563162,0.038673926,-0.043206647,-0.05312747,-0.03609213,0.015010383,-0.064853214,-0.00046905226,0.01913597,0.10327664,0.053989664,-0.05684776,0.022912048,0.07886822,0.01768479,-0.027949143,-0.014844184,0.030927777,-0.0054793297,0.0017176259,-0.04615536,0.06083729,-0.00829074,-0.09931706,-0.0206722,-0.016786369,0.025472503,0.028917003,-0.020957962,-0.022773843,-0.005666466,0.06372287,-0.03461612,0.011717802,0.025346892,-0.006080118,-0.033768184,0.018650383,0.11646203,-0.024205206,-0.013057759,0.032579277,0.025695087,-0.04268574,-0.005491221,-0.025233965,-0.056534547,-0.055280846,0.09465115,0.054578662,-0.026138391,0.01548487,-0.024367455,-0.023405386,0.017147737,-0.118469186,-0.073189944,-0.05962378,-0.008424422,0.059139535,-0.013263985,-0.0041656634,0.040447883,-0.0004499096,0.0116618555,0.027260564,-0.06293575,-0.055347454,0.0465285,0.05505276,-0.0416385,-0.004972005,-0.037544552,0.012688175,-0.05441053,0.028252503,0.10695248,-0.09482442,0.053052735,-0.10168862,4.401061e-34,0.11197989,0.042112295,0.00053872983,0.040945873,-0.04922403,-0.026287258,-0.10514996,0.0108647775,-0.13489334,-0.026883759,-0.031249471,-0.08895821,0.073553465,-0.028456943,0.0061260755,-0.048745215,-0.006599593,0.089179456,0.07740579,-0.009920181,0.028831778,0.031384513,-0.056118745,0.050226703,0.04727217,0.031706095,0.037976533,-2.286906e-06,0.09795692,-0.023158964,0.029373053,-0.10835855,-0.056454863,-0.012515949,0.06451263,-0.08220741,-0.12111949,-0.07287224,0.037881497,0.10453092,0.053057548,-0.015659278,0.02095193,-0.0056263367,0.04164281,-0.0044095614,0.01813011,0.04127036,0.02823675,0.019974533,0.025550302,0.013652855,0.06281992,-0.09286964,-0.08048551,0.038351398,-0.014609395,-0.035681944,0.1045704,0.027254663,-0.04992357,0.06740779,-0.054798763,-0.08288167,-0.0057152943,0.030083159,-0.047984954,0.039779197,0.06738687,0.013943551,-0.02575852,-0.04235387,0.04937766,-0.01324911,0.024226213,0.07231911,-0.06364613,0.0240954,0.04221052,-0.030414421,-0.002107642,0.061912037,-0.007965784,-0.118887044,0.047755897,-0.009344176,-0.06747634,-0.019690797,-0.060736906,0.085682735,0.040709205,-0.0133067,-0.015976455,-0.033046998,0.021911543,-1.0328582e-33,-0.012647878,-0.03697198,-0.050203856,-0.090945646,-0.035090882,-0.008575413,-0.03463843,-0.1277608,0.07880277,-0.025951678,0.0016437768,-0.045079716,0.123479195,-0.07345293,-0.049026664,0.034562413,-0.013388368,0.038279846,0.06900491,-0.0156528,0.03440773,0.029508818,0.057692938,0.044240467,-0.007390772,-0.027498523,0.051518444,0.07083893,0.105078585,0.008673444,0.05999203,-0.024353074,-0.0039253454,0.043673627,-0.069246635,-0.004351342,-0.035095345,0.06347908,0.029176036,-0.02392878,-0.050356563,-0.038256746,0.0047164746,0.026991801,0.06127375,0.047464173,-0.003664453,0.02134431,0.012019595,0.040152553,0.015818603,-0.04924004,-0.03726256,0.04055935,-0.002779771,0.012885225,0.02484018,0.062168807,0.074824885,-0.029203635,0.041530605,-0.06957457,0.051925883,0.06407002,0.044317286,0.080734834,0.024134926,0.030073507,-0.0141402325,-0.08444767,0.06724083,0.05615304,0.008389726,0.06353477,-0.07470676,0.0016305981,-0.012770818,-0.039235972,-0.022162788,0.012190903,-0.051715594,0.018306984,-0.04579156,-0.062142015,0.0027267155,-0.013846505,0.038209982,0.09314648,-0.02377715,0.015985955,-0.05220473,0.05893802,0.013240248,0.038172018,0.09052888,-3.732241e-08,0.054036003,-0.03649924,0.018052127,-0.049809806,-0.013510366,-0.07343184,0.0743981,-0.031745356,-0.02333906,-0.06786507,-0.036556277,0.053829644,0.06354807,-0.016090302,0.15077066,0.002456983,-0.02881667,0.0055002375,-0.027290348,-0.004678673,0.103195675,0.027839443,-0.082155004,0.036293067,-0.06628227,-0.018590324,0.02178721,-0.0068642674,0.041979242,-0.027282754,0.08792168,0.055904407,-0.00760606,-0.017245393,-0.08427118,-0.03705449,-0.024851855,0.055986367,-0.010972153,0.032636672,-0.015345042,-0.052313585,0.006394336,0.034158375,-0.08073251,0.009847984,0.03764635,0.00029821828,0.0375384,0.010957805,0.071658835,-0.0038476377,-0.0024461814,-0.008392059,-0.059437975,0.015666386,-0.057087354,-0.061037403,-0.0068513216,-0.014552938,-0.04323378,-0.04437663,0.18258658,-0.0015318695 +3.7.1.16,"The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 1.17.1.7, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. +Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway [1,3,4]. The enzyme from Escherichia coli also exhibits enoyl-CoA hydratase activity utilizing crotonyl-CoA as a substrate [2].",384,1.0,-0.096451946,-0.07889956,-0.004002871,-0.02192036,0.13488412,-0.0025345327,-0.077002205,-0.028561858,0.013388704,-0.05839254,-0.038870666,-0.06998413,-0.037316725,0.0634925,-0.015841288,0.030338846,-0.06913301,-0.03160239,-0.03643151,-0.047562726,0.059250902,-0.021237323,-0.058102757,0.0966754,0.11377224,0.02790155,0.063162126,0.027909532,-0.06497608,-0.026097745,0.020702288,-0.043206528,0.011662835,-0.01575359,0.05780481,0.09643926,0.012830962,-0.10382894,0.08960885,-0.0031346444,-0.011572723,-0.00092117087,-0.040902346,-0.03894296,-0.030255383,-0.050293695,-0.013522945,0.015813498,0.0891108,-0.027638767,-0.038212515,-0.03791778,-0.029739188,0.017795341,0.029319331,0.04597431,-0.00071986363,-0.05592895,-0.02925484,0.01143332,-0.0068923007,-0.024231143,0.0355936,0.03465038,0.013086592,-0.09330184,0.012123041,-0.017574178,0.018631786,-0.020495236,-0.10798559,-0.059130743,0.037092138,0.053285465,-0.06315011,-0.0052163242,0.0043723835,-0.054175913,-0.0066162366,-0.012020446,-0.02301093,0.013191997,0.016408723,0.07270476,0.040566657,-0.034993853,0.01443754,-0.04261765,0.037414066,-0.017528262,-0.016820608,0.0071490076,0.030081613,-0.048546843,-0.031032996,0.09389247,0.009999758,-0.009502112,0.026294049,-0.03883845,-0.043054417,0.12851106,0.032151397,-0.036105245,0.040483132,-0.024144782,-0.003922595,0.19886884,0.0108139375,-0.038249783,0.016241236,-0.040351663,0.10289739,0.050737757,0.023299241,0.09132249,-0.03153194,-0.010093182,-0.049935997,0.044115923,0.013413306,-0.052930783,0.057360593,0.036741156,-0.01643733,0.021746565,-0.050452765,4.059843e-33,0.06746729,-0.017369207,-0.020800764,0.00663722,-0.004254937,-0.00021267269,-0.09294627,0.11093205,-0.05283782,-0.025928877,0.0013575358,-0.02821219,0.09311742,-0.003573826,0.012221098,-0.058296103,-0.023920719,0.012326911,0.02336106,0.07295433,0.008575728,0.024645202,-0.004688418,0.033543527,-0.044781003,0.071447566,-0.020378776,0.07069299,0.046814203,0.009776435,-0.009887997,-0.047788527,-0.07456191,0.007948903,0.059630424,-0.090686455,-0.091902286,0.025871662,-0.03449624,0.12301546,0.062817305,0.032792732,-0.04612838,-0.075874865,0.031503875,-0.01584865,0.0011231885,0.083321266,0.008495264,0.010017906,0.0333863,0.0012074044,0.107348196,-0.06828834,-0.028020306,0.019775921,-0.0071127503,-0.026457341,0.07905567,-0.00291499,-0.036764372,0.03423221,-0.038142707,0.033615198,0.01794903,-0.008548163,-0.032390866,-0.06426874,0.029404327,0.0745182,-0.028384775,0.06342766,0.011495687,0.027011845,0.05952077,-0.071222685,-0.02393521,0.019086415,0.03784251,0.0052756355,0.025303723,0.037382234,0.04104835,-0.016284002,0.0066933734,-7.010668e-06,-0.026314495,-0.0318363,-0.009660992,0.07644846,0.02819421,-0.1345569,-0.0018038587,-0.06773613,-0.022983948,-3.3974645e-33,0.12248763,-0.11039906,0.022638233,-0.14477392,-0.10032693,0.104000196,5.4823955e-05,0.00012189415,0.008938616,0.010345103,0.10612746,0.07046137,0.0025459921,-0.032368626,0.00076094235,0.0617895,-0.013241495,-0.014487976,-0.034174502,-0.004068626,0.07095537,0.05559701,0.043762174,-0.030126527,0.11395043,0.045326054,-0.015111871,0.016546054,0.04205662,0.017318279,-0.008574146,-0.052716866,0.006002382,0.036227692,-0.05015327,0.065564744,-0.09991307,-0.0028335778,0.030071115,0.028287956,-0.0030077891,0.019582625,0.006354838,0.007848975,0.001828751,0.008044654,-0.103237085,-0.00010055515,-0.031920128,-0.03812337,0.015378684,-0.05676783,-0.08674743,-0.014157062,-0.01943961,0.00872763,0.029809913,0.014764825,-0.019932112,-0.034735367,-0.021882871,-0.018819818,0.03608788,0.032088414,-0.0010738991,0.049120147,-0.04643791,0.09521034,4.9919614e-05,-0.0025647345,0.060473032,-0.022505628,0.06971062,0.026296942,0.02574115,-0.025096288,-0.0537413,0.01924703,-0.03112068,0.047765855,-0.039806843,-0.029003264,-0.06031464,-0.066560164,-0.070459336,-0.08948458,0.017116088,0.07176036,0.001487108,0.012621729,0.023611184,-0.0757732,-0.009893243,0.0682948,0.12835,-3.988679e-08,-0.0070431223,-0.08407414,0.04266909,-0.01126587,0.047183573,0.039697234,0.013764867,-0.05235367,0.05706308,-0.011957874,0.036226757,0.016574038,0.059978474,0.020874962,-0.04400792,-0.03593984,0.009633906,-0.011306055,0.01020782,-0.023980016,-0.02871483,-0.024856625,-0.08429369,0.07901426,0.051894203,-0.056534007,-0.037134897,-0.0007038934,-0.06420063,-0.054935344,-0.032555234,0.020458356,0.025931215,0.0035849826,-0.034539413,-0.01352418,-0.021842323,-0.04096424,-0.09784647,0.0654275,0.045477927,-0.0013911925,-0.10750419,-0.016784549,0.064639606,0.06407485,0.021846851,0.010138727,-0.03271106,0.0038893325,0.068434745,-0.014698606,0.030657142,-0.005454934,-0.08648587,0.0055464255,-0.008599328,-0.10964961,-0.06338736,-0.036161404,0.027482353,0.03572766,0.1816239,-0.035660405 +4.2.3.86,"The recombinant enzyme from Vitis vinifera forms 49.5% (+)-valencene (cf. EC 4.2.3.73, valencene synthase) and 35.5% (-)-7-epi-alpha-selinene. Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium. ",384,0.9999999,-0.022601983,0.005927175,-0.11879448,-0.02088927,-0.009843998,0.066822566,-0.046609778,0.102250636,0.04580619,-0.023191905,0.026584804,-0.009890996,-0.037023436,0.01645822,-0.07444803,-0.03172956,-0.014609151,0.030370897,-0.012077425,-0.021767382,0.03152799,0.027693631,-0.015728263,0.022915129,0.094644785,-0.043637518,0.010188754,0.002222348,0.03167372,-0.020496381,-0.061501306,0.046951175,0.031197244,-0.06305132,0.009988319,0.021463644,-0.000655294,-0.06527988,0.022542134,0.043185227,0.020758327,0.024276584,-0.0750927,0.043131508,-0.0075514982,-0.015367779,0.043665558,0.031064242,0.04761783,0.03913195,-0.027517917,-0.03996282,-0.08163171,0.022324644,-0.040844996,-0.029168587,-0.029573811,-0.02262089,0.024767555,0.027361222,0.058620356,0.043656297,0.027194867,-0.020278726,-0.021842463,-0.06215872,0.0018375783,0.01836705,-0.051590137,-0.04617198,-0.044322953,-0.039894618,-0.038684558,-0.014419766,-0.018603202,0.07439672,-0.012559137,0.047530204,0.033874083,0.02593928,-0.014302332,0.034052454,-0.028761815,0.058916014,0.015532771,0.051583096,0.06358009,0.026379794,0.053401213,0.038859002,0.0018222325,-0.008389867,-0.0036454706,-0.0846493,0.052822694,0.010164715,-0.007512183,-0.05676978,0.029218635,-0.021119304,-0.03846619,0.028256113,-0.057816483,-0.028205045,-0.09551819,0.06174816,-0.063843586,0.12297898,0.014128294,0.0030892373,-0.024057336,0.04068536,0.08447081,-0.033692546,-0.0035447835,0.1836883,0.013924277,-0.019668026,0.0033144022,-0.007963481,0.020595785,0.018519863,0.0821867,0.09171245,-0.027682243,-0.031459443,-0.021752343,2.0944703e-33,0.022538027,0.036049176,0.041876413,0.06482708,-0.05524705,0.025559988,-0.0915863,0.050560966,-0.10324983,-0.05729089,-0.14759326,-0.06774895,0.09614917,0.027372831,-0.03070781,0.013122568,0.06916488,-0.047436632,-0.08215785,-0.027644925,0.031489108,0.0070775137,0.022468632,0.034052767,-0.0393029,-0.012342333,0.033375684,0.005817362,0.012546896,-0.04898912,-0.04601994,-0.07864117,-0.024248986,-0.02886578,0.045716636,0.010016612,-0.02086784,-0.025748286,0.011309949,0.06597383,-0.0076562515,0.07735995,0.024896199,-0.059099827,0.04939153,-0.078805484,-0.066918604,0.045475837,-0.008305583,0.028213628,-0.018239524,0.069849804,0.004514987,0.010859311,-0.10981036,0.051911738,0.05827506,0.033586357,-0.016006837,-0.011358825,0.039350037,0.074056186,-0.0021286774,-0.0406978,-0.04448973,0.08092245,-0.118200555,-0.039605785,-0.04343277,0.12264779,-0.051818065,0.010295228,-0.019127063,-0.061318092,0.061733685,-0.05553947,-0.09890019,-0.08953009,0.033415176,-0.007460232,-0.112238765,0.009947981,-0.010235514,-0.049425278,-0.023962917,-0.132076,-0.043584555,-0.02426047,-0.011050942,0.08499757,0.050734665,-0.033650625,0.004120319,0.010692685,0.052747767,-2.444652e-33,0.017309295,-0.080503315,-0.008175887,-0.065311246,-0.04346185,0.04702454,-0.019526206,-0.056277934,-0.05456935,-0.04977384,0.050049625,0.013397285,0.0017977504,-0.0025284137,-0.050617598,0.005683147,0.03295027,0.07180278,0.03480086,-0.031002894,-0.026474083,0.008095908,0.05125215,0.0075029945,0.06754794,-0.038177315,-0.0087564215,0.08462037,0.0074695996,0.011073912,-0.011469808,-0.047331277,-0.058887567,0.008303902,0.011145998,0.04707528,0.00835676,-0.011186035,0.06385094,0.049150676,0.028144555,-0.017397746,-0.0007762294,0.09677349,0.017934827,0.05636261,-0.05826739,0.0809533,0.059011526,-0.00830674,0.09976367,0.0068044597,0.04454201,0.06337203,0.02952556,0.06832941,0.032361567,0.016175376,0.03442761,-0.0024820177,0.036762122,-0.05032801,-0.017761337,-0.09678807,0.031325534,0.0052281893,0.018986162,0.12492337,0.026978059,-0.074786365,0.11187736,0.033440188,0.010005493,0.0706992,0.011731291,-0.10349515,0.012591683,-0.0666656,0.023499811,-0.08675304,-0.03620177,0.018699858,-0.033857316,-0.064207576,0.002799264,-0.018843053,0.033110287,0.05218519,0.055120442,0.042138536,-0.024229573,-0.008446189,-0.032254126,0.014959073,0.07935903,-4.5544287e-08,0.02717042,-0.061368056,-0.034786012,-0.0574664,-0.02116419,-0.0019908114,0.008027501,0.02962814,0.026612788,-0.037799112,-0.009133136,0.05268247,-0.027957326,-0.0025614917,0.069120705,0.055853944,-0.00068638736,0.050892588,-0.020343367,0.004076128,0.019111903,-0.01000105,-0.122157745,-0.028607748,-0.03226393,-0.14610618,0.010399418,0.009056636,0.0013664499,-0.035018943,0.03432215,0.045168728,0.02684767,-0.03696772,-0.12342785,0.047259077,-0.012231844,0.06069688,-0.018976672,-0.014089877,0.02725846,-0.04776272,-0.057297595,-0.042966083,-0.02790134,0.0036847896,0.07959991,0.02763495,0.022031887,0.004288612,0.06168406,0.05771134,0.0858552,-0.024909995,-0.097547114,-0.010839065,0.008685203,-0.088212304,0.045539137,-0.11174427,-0.052192956,-0.059413474,0.19733077,-0.017264893 +4.2.3.87,"Requires Mg2+. The enzyme from Pogostemon cablin gives 13% alpha-guaiene as well as 37% (-)-patchoulol (see EC 4.2.3.70), 13% delta-guaiene (see EC 4.2.3.93), and traces of at least ten other sesquiterpenoids [1]. In Aquilaria crassna three clones of the enzyme gave about 80% delta-guaiene and 20% alpha-guaiene, with traces of alpha-humulene. A fourth clone gave 54% delta-guaiene and 45% alpha-guaiene [2].",384,0.99999994,-0.034157,-0.09719266,-0.0789265,0.014880706,0.012184626,-0.040667333,0.0590271,0.051534716,0.04608835,-0.03721764,0.049963694,-0.045164883,-0.03263904,-0.012119926,-0.051317587,0.009214292,0.035365786,0.0031983263,0.047966365,-0.046830952,0.017166741,-0.03867438,0.02734698,0.007443452,0.0027424514,0.006670591,-0.030511357,-0.06066106,0.055255376,-0.08250361,-0.009041233,-0.010021285,0.084993675,-0.02659209,-0.05815912,0.07952122,-0.06034666,0.012245519,0.023159757,0.005095644,0.05046485,0.041767955,0.040853713,-0.0284109,-0.033312798,-0.09832778,0.018795012,0.0150738545,0.031993724,0.0719703,0.0014609665,-0.078598045,-0.08205375,0.017147345,0.0013306137,-0.029081138,-0.07754065,0.020472297,-0.025109468,0.052454907,0.030264081,0.040804274,-0.020015862,-0.060073145,-0.022995677,-0.03474236,0.012823951,-0.04451517,0.007587064,0.016998883,-0.0034349207,-0.02882164,-0.044260357,-0.04456413,-0.116282195,0.12602933,0.019583575,-0.014362445,0.01310874,-0.00470047,-0.00317701,0.0078773815,0.06023148,0.120653614,0.058490966,0.065122545,0.0054452484,0.04014438,0.0380869,0.047352977,0.15523775,0.09379831,0.01370574,-0.025320822,0.0033680731,0.09816233,-0.036156323,0.03500244,-0.058457833,-0.031278756,0.03610205,0.025641788,-0.057249017,-0.070089914,-0.08528444,0.05324569,0.0029309022,-0.07449558,0.053492397,0.0023923358,-0.0011136429,0.024498597,0.035943527,0.027802426,-0.008577521,0.07544557,0.020588014,0.0039897067,-0.0044625634,0.030969037,-0.029721728,0.020674886,0.002947923,-0.01834259,-0.043434534,0.015457902,-0.01839236,5.721371e-33,0.0342738,0.058812108,0.052869003,0.050125502,-0.023394858,0.034305513,-0.075707495,0.047074325,-0.037078496,-0.07653758,-0.16265918,-0.08280217,-0.05530457,0.036531087,-0.020507153,-0.028476825,0.008712439,-0.081868306,0.079022385,-0.03205756,0.0006672255,0.015963037,-0.05794532,-0.02244222,0.010967713,0.031281598,0.02966845,0.0025924593,-0.021834452,-0.018537737,-0.006521685,-0.062536284,-0.007531127,0.027140893,-0.010845816,-0.030091366,0.011480324,-0.012019389,-0.08170686,0.0036832492,-0.016840525,0.03310041,-0.02397505,-0.009404427,0.054904327,-0.08974723,0.012933026,0.054315526,0.09355467,0.068874724,-0.0303883,2.18771e-05,0.017236069,0.022436904,-0.12249061,0.011891866,-0.032598175,0.018654058,0.08249603,0.084575705,0.022369906,0.010991426,0.050097547,-0.04078677,0.048339844,0.14815158,-0.1010162,-0.019211277,-0.031324312,0.072315745,0.018009672,-0.036965247,-0.038468126,-0.030996732,0.09075478,-0.03131369,-0.042387463,0.011288543,0.06851725,-0.016476823,-0.1099117,-0.039890908,0.02947663,0.044937134,-0.114765994,-0.018304646,0.027205106,0.114092335,0.067184836,0.07430804,0.060352873,-0.061238106,-0.06619938,-0.0039617997,-0.02058091,-3.9513247e-33,0.008467407,-0.080049045,0.043755192,-0.030013995,-0.07044915,0.08096219,0.033126358,-0.044581145,0.033234138,0.0023353419,0.019503383,0.022154894,-0.0025504066,-0.09861431,-0.029322775,0.02797685,0.003681969,0.08208609,-0.025600245,-0.0546842,-0.045505196,0.056944728,0.056680694,0.08291203,0.011430284,0.044758268,0.07468353,-0.033102304,0.015788743,0.065180175,0.017881356,-0.0055219308,-0.04876584,0.037467543,-0.07117254,-0.017222606,0.016678536,0.043874774,-0.04096184,0.035306655,-0.008438553,0.029836275,0.02566406,0.08923036,0.09160162,0.04266484,-0.08618458,0.021558153,-0.043740205,-0.054140575,0.06795605,0.0011681084,0.039270908,0.013850059,0.054529075,0.002396801,-0.050883252,-0.021911401,0.02677508,-0.009584267,-0.029953502,-0.050087214,-0.09079805,-0.05717487,0.07901834,0.029053153,0.0034991144,0.12476804,0.020617599,-0.0034194281,0.038222354,0.010611967,0.049322292,-0.009459921,-0.021741757,0.03297041,0.035187557,-0.06973074,0.07594921,-0.081839174,-0.027417477,0.01771599,-0.04273009,-0.09578918,-0.048668362,-0.051634114,0.052666456,0.058970492,0.09687454,0.06793466,-0.034217216,-0.013615463,-0.07194012,0.044529445,0.12185475,-4.6289657e-08,0.0026120779,-0.03171891,0.032805078,0.023213653,-7.4058546e-05,0.041604,0.013889928,0.04597587,0.03532773,-0.0036967904,-0.0021734787,0.0057474277,0.03624966,0.05719413,0.006037578,-0.011617255,0.059626535,0.06759595,-0.0067905746,-0.0025126934,-0.05967138,-0.025596041,-0.13352667,-0.029901883,0.010312602,-0.08605086,-0.008351835,0.047488604,-0.024024071,0.044747915,0.03339457,-0.06094539,-0.014387867,-0.052856684,-0.030781815,0.047088854,-0.03409043,-0.064378135,0.018073196,-0.023264939,-0.05044246,-0.05198057,0.028484235,-0.023589104,-0.044394467,-0.02593473,-0.020487558,-0.014331947,0.021528592,0.07276242,0.086510785,-0.035167966,0.0010146762,-0.048294246,-0.0833737,-0.10085596,0.022828808,-0.04322311,-0.023789288,-0.13831146,-0.018177371,-0.020110222,0.07617495,-0.02436743 +4.2.3.88,Viridiflorene is the only product of this enzyme from Solanum lycopersicum.,384,1.0,-0.012507814,-0.048286065,-0.13944885,-0.015958937,0.17491746,0.061215803,-0.108287945,0.09398635,0.0060897092,-0.04366406,0.07483984,-0.101840675,0.026606547,-0.0150296595,-0.038594794,0.031187188,-0.031725354,0.005777671,-0.013926851,-0.050863393,0.041425522,0.08470367,-0.026710764,-0.024228394,0.042485904,0.013802147,-0.04752147,-0.012016942,0.0011329055,-0.06875488,-0.020622963,-0.004613447,-0.007914813,0.011270136,0.067883305,0.03254392,-0.09558168,-0.02187835,0.029356904,-0.032513358,-0.021604156,-0.017885048,-0.05191565,-0.032449093,-0.020072103,0.06238199,0.0045925323,0.009952679,0.061946265,0.017918035,-0.053236313,-0.010502444,-0.021762285,0.0138987135,-0.029983053,-0.04802628,-0.01884043,-0.021637985,0.0011490989,0.059939504,0.029467419,0.013028966,0.041944783,-0.05012839,0.0077241673,-0.053027477,0.008996641,-0.008650791,0.02576409,-0.035408672,-0.050269037,-0.10193566,-0.0003905228,0.06720033,0.0014402912,0.039714333,-0.036439776,-0.007545164,0.05207943,0.019439062,0.029031344,-0.040240876,-0.0013113196,0.059622094,0.028856434,0.0069480725,0.0007667943,0.004224585,0.10133521,-0.0021500748,0.021298775,0.06693384,-0.064626254,-0.043990273,-0.020100852,0.019126164,-0.037392266,-0.040871255,-0.027611565,-0.003253559,-0.065555625,-0.07764386,-0.006193154,-0.08015938,-0.08994096,-0.03106864,0.04755729,-0.005174138,-0.019003253,-0.019571308,0.044703644,0.07440525,-0.00044568547,-0.050957542,-0.016325472,0.064921804,0.049021948,-0.02586561,-0.08248151,0.016605293,0.009875576,0.0014947047,0.11497744,0.017162973,-0.06032148,-0.0045803804,0.011814437,8.356837e-34,-0.011275584,0.04807985,-0.017549329,-0.056995545,-0.018297942,0.024309378,-0.0120260995,0.10195942,-0.045109406,-0.076910496,-0.09668481,-0.095405184,0.04178766,-0.014724462,-0.033604104,0.0037738436,0.024651615,-0.042519644,0.002605745,-0.01729,0.023819411,-0.0010640644,-0.039605826,0.09320236,-0.069744006,-0.050998967,0.04364215,-0.01376578,0.044688717,-0.05055789,-0.0019947668,-0.013024634,-0.019461153,0.02413371,0.080657884,0.062069785,-0.06310981,-0.06983686,-0.016017262,0.05940449,0.00889238,0.065915845,0.023410909,-0.01222785,0.060865454,0.04948566,-0.101812124,0.064702414,-0.015835823,-0.017360017,0.03862345,0.020768827,0.0260671,-0.056259844,-0.025257425,0.04699762,0.030063154,0.051041596,-0.02026915,0.015667893,-0.11414496,0.026670372,-0.014506053,0.008570559,0.0008366336,0.0066286507,-0.077124916,-0.033593103,0.002330674,-0.020754049,-0.002888893,-0.007983783,0.07920141,-0.023905335,0.059784856,-0.040454734,-0.01623788,-0.005881284,0.020088598,-0.029184533,-0.046854258,0.033919446,0.0772495,-0.030677186,-0.030800223,-0.057902966,-0.0710151,-0.0010338335,0.03935945,0.016021188,0.055325698,-0.026257906,-0.004313678,0.016395966,-0.004796676,-1.0012438e-33,0.026355943,-0.017776499,0.10890967,0.015720587,0.02320951,0.08159219,-0.028970957,-0.043694615,0.016046328,0.02432733,0.110712714,-0.035829082,0.02778688,-0.05130573,-0.051871013,0.12966552,0.0669252,0.0695343,0.018798718,0.022668725,-0.09263214,0.10873305,0.030250257,-0.046065405,0.037032746,0.0038129182,0.028418342,0.09844978,0.0011589888,0.032099623,0.027323358,-0.01198377,-0.014995493,-0.0768703,0.0058893026,0.05561487,0.0015061926,-0.059124965,0.05137352,0.092565626,-0.043867886,0.023192136,0.0065381983,0.010823479,0.0075460738,-0.022010649,-0.012051217,-0.026263805,-0.069135055,-0.070558876,0.05330745,0.008647159,-0.030345106,-0.025431303,-0.027739359,0.050786585,0.035963554,0.051108383,-0.0015162994,-0.01488333,0.07199355,-0.05814854,-0.052322872,-0.016391816,0.035368666,0.0777426,0.040185273,0.085545614,0.06102534,-0.04462364,0.10369678,0.032128986,0.04071967,0.037854146,0.00016650399,-0.0033920808,0.004639665,-0.031412784,-0.039009735,-0.09103459,-0.001957432,-0.03684027,-0.0036996612,-0.105331644,0.015053452,-0.056195494,-0.0074200644,0.016408952,0.018471695,0.056472097,-0.07503997,-0.01415303,-0.033964463,0.046188433,0.14991471,-2.2316565e-08,0.061179053,-0.06330858,0.0215862,-0.050026994,0.074134775,-0.003489292,0.03164522,0.028738648,0.05845311,0.04676828,-0.035765264,0.037872802,-0.08381022,-0.021446586,0.10259735,0.009739485,0.02293121,0.07315995,-0.045867532,0.07113289,-0.024365535,0.051417325,-0.11212868,-0.06366786,-0.03616061,-0.04571361,0.02326579,-0.06886222,0.03913443,-0.020327609,0.05363416,0.03058553,0.038460586,-0.08008141,-0.18386059,0.016673535,0.024323082,-0.055927537,-0.03247971,0.0660578,-0.009171159,0.013926075,-0.0415262,0.021377569,-0.09021864,0.0046317074,0.020746237,-0.044030096,0.0027819998,0.020374075,0.039235767,-0.012204756,0.011928287,-0.0034665556,-0.05823079,0.003513512,0.068738595,0.021537583,-0.03537659,-0.0821328,-0.029386733,-0.02291431,0.23471169,0.026919533 +4.2.3.89,"A multifunctional enzyme which also converts the (+)-beta-caryophyllene to (+)-caryolan-1-ol (see EC 4.2.1.138, (+)-caryolan-1-ol synthase). cf. EC 4.2.3.57 (-)-beta-caryophyllene synthase.",384,1.0,-0.0771976,-0.03888432,-0.08789038,0.058703348,0.024009043,0.08224857,0.003461427,0.0013485507,0.016286204,-0.06561403,-0.014892609,-0.023711817,-0.11285918,-0.0034359265,-0.06418299,0.013805143,-0.12566935,0.05800637,-0.034965146,-0.003716715,-0.03609374,0.017623799,0.035808478,0.09968076,0.02758418,-0.036591984,-0.017686654,-0.04185605,0.011097709,-0.07807231,0.06386462,0.023444733,0.0642027,-0.03507406,0.06612196,0.004209491,0.003952142,-0.11542077,-0.03128918,0.027387036,0.10456063,0.016943576,0.0033055488,-0.0019576845,-0.008775525,-0.024491733,0.022762854,0.034404125,0.024497831,-0.036891423,-0.0775551,-0.056981757,-0.0941872,-0.045474954,0.051052153,0.04854065,0.03524691,-0.00743856,-0.032181703,0.048129063,0.051044688,0.021375865,-0.022086496,0.022976682,0.010655568,-0.012220549,-0.015293844,-0.033236433,0.03789277,0.0006753336,-0.10801749,-0.059322547,-0.037681174,0.037480712,0.056477405,-0.014501841,-0.02482114,-0.017477416,0.07490078,-0.00637827,-0.024518337,0.018377647,-0.04873419,-0.028245047,0.029087579,0.071900666,-0.034353815,0.032881614,0.057178676,0.0526835,-0.018822,-0.05049813,-0.010466253,-0.048570447,-0.08256658,0.035099503,0.0095344195,-0.046702985,0.038423445,0.015771868,-0.04687385,0.0084713455,-0.04329841,-0.065244064,-0.0846737,0.007009209,0.070310764,0.017590389,0.03786928,0.013923383,-0.032654103,-0.024514856,0.032706622,-0.04645148,-0.044386543,0.076588206,0.014950213,-0.065473154,0.0412408,-0.0049392222,0.028414013,-0.051589835,0.04146419,0.10936697,-0.108325265,0.084681146,-0.11279283,-2.14132e-33,0.08974313,0.08636676,0.07025402,0.029856166,-0.01789954,0.013124349,-0.10432562,-0.034301624,-0.08926201,-0.043336436,-0.02447506,-0.014253171,0.0006704763,0.03816919,0.048100956,-0.05366824,-0.039541967,0.05049841,0.062338542,-0.015641345,0.00048205658,0.060386848,-0.09771707,0.07056039,0.060476366,-0.010573519,0.018298632,0.021133866,0.032456975,-0.0070080855,0.03393547,-0.015343249,-0.11272771,-0.028907603,-0.0022296228,-0.06184719,-0.054302685,-0.103752464,0.027325304,0.12237564,-0.02621147,0.0112009505,0.040625434,0.018618176,0.09294565,-0.034893937,-0.0146653615,0.085614726,0.057224542,0.011824782,0.0039541707,0.0009693482,0.08497953,-0.046860565,-0.05343986,0.07274669,-0.023061542,-0.011067232,0.05609579,0.004185421,-0.015346593,0.06022064,-0.03277864,-0.12120638,-0.011546667,0.038941734,-0.029077897,1.3187099e-05,0.018806675,-0.013066521,-0.020811582,-0.04682983,0.0071475646,0.0020363464,0.047676474,0.026444698,-0.0695684,0.008134805,0.0037925914,-0.05014792,-0.06926193,0.066608384,0.027840605,-0.097470455,0.020161413,-0.021655614,-0.022067681,-0.016402012,-0.04817364,0.040285297,0.06079857,0.019444253,-0.048780225,0.033994865,-0.009973558,1.5457692e-33,0.010141532,-0.07403423,-0.051057328,-0.064236894,-0.067532755,-0.05477045,-0.016351964,-0.117303975,0.07574119,-0.043694567,0.013143609,-0.04429624,0.14623377,-0.07828759,-0.018589374,-0.03720631,-0.018934533,0.014652107,0.038995665,0.017706191,-0.013216255,0.02733699,0.019734457,0.034791905,-0.005791058,0.01992709,-0.0063073323,0.10662564,0.116158694,0.011968849,0.032407377,-0.060217027,-0.017928112,0.019415634,-0.058855273,0.02741906,0.04131776,0.052839678,-0.0038761517,-0.033779107,-0.009741203,-0.028089488,0.019237587,0.034673624,0.04050092,0.07480955,0.0019431844,0.025784682,-0.0051052626,-0.0020126924,0.02139013,0.028690042,-0.044777766,0.05253104,-0.0113348095,-0.0022713414,0.03138419,0.00039616408,0.039426353,-0.06937482,0.018254993,-0.07889412,0.0810864,0.0508685,0.06331834,0.07144732,0.01619526,0.018905241,-0.0073372805,-0.068272546,0.103149444,0.045934506,-0.0027216857,0.074062,-0.045718648,-0.014886346,-0.07679589,-0.090755925,-0.029007532,0.0068188603,-0.04338352,-0.026094602,-0.035450414,-0.031150302,-0.027541596,-0.037694138,0.06932396,0.0879303,0.03614806,0.027893417,-0.03095359,0.061205164,-0.027384471,0.029292164,0.02755552,-3.2866076e-08,0.039814454,-0.029438106,0.007863176,-0.0741481,-0.01252634,-0.038874343,0.049364474,-0.036977533,0.013326771,-0.040082492,-0.04668236,0.083091415,0.08006416,-0.007971247,0.11179948,-0.0075291893,-0.024126414,-0.0077586495,0.0010518914,0.002302214,0.0076164017,0.076380685,-0.05869999,0.0039394894,-0.07609473,-0.07196032,0.02496267,0.060108457,0.07566126,0.0030634303,0.05092439,0.066724814,0.05115751,-0.026129484,-0.109299324,0.03919165,-0.0002918917,0.041384295,-0.012462324,0.039346132,-0.006740374,-0.0923177,-0.027315615,-0.0018243328,0.002755659,-0.01710581,0.10381954,-0.015352966,0.03947677,-0.014853014,0.10514297,0.019350352,0.000991495,0.0056707747,-0.07488655,-0.0146388495,-0.048651874,-0.032573774,0.030756274,-0.0064591444,-0.03930436,-0.04230016,0.19997519,0.032104556 +4.2.3.90,"Requires Mg2+. The enzyme forms 5-epi-alpha-selinene possibly via germecrene A or a 1,6-hydride shift mechanism.",384,0.99999994,-0.080652386,-0.040843274,-0.0034864512,-0.022758013,0.041697163,-0.050261017,-0.0550114,0.0020945386,-0.054588534,0.02863672,0.012412394,-0.049414847,-0.006772715,-0.003007854,0.024767507,0.019949168,-0.077543475,-0.0035361934,0.0035952833,-0.035618976,0.09496755,-0.025629777,0.03261518,0.026234994,0.00013061044,-0.017010195,0.08059358,0.0119032785,0.01376307,-0.04344105,0.006650038,-0.02389507,0.031753432,-0.034749705,-0.031293847,0.093714975,-0.057267416,0.007510903,-0.0040885448,0.027168231,0.053201042,-0.043401,0.008621539,-0.04354036,0.0035817183,-0.121503115,0.034920268,-0.028258825,0.054409623,0.07583074,-0.034019373,-0.029106092,-0.06336845,-0.023879426,-0.0020968209,0.009795093,-0.10414864,0.03061642,-0.01868931,-0.018924482,0.028811594,0.006910566,-0.03699457,-0.028118627,0.01458916,-0.0010826899,0.004445422,-0.059826892,0.015227319,0.0005436198,-0.02101794,-0.07728896,-0.027381884,0.040482473,-0.06230282,0.00827765,0.034675926,-0.046497785,0.089472234,0.02178151,-0.04031179,0.013495198,0.06698846,0.10059754,0.048691712,0.06464884,0.04533311,0.012986512,-0.0015243965,0.070661455,0.118581705,0.018210141,-0.03622546,0.022082541,0.020174988,0.04818826,-0.063387685,-0.012305264,0.013482537,-0.0073987637,-0.046657383,0.04574142,-0.038004376,0.034890063,-0.11884545,0.014604729,0.01817522,-0.0048791384,-0.04628982,-0.0058252565,0.043547757,-0.029106067,0.047410104,0.026810262,0.020171972,0.100637384,-0.03738348,-0.049391918,0.01817174,-0.017578429,0.0029439563,0.026452517,0.005918962,0.09938855,-0.09314277,0.052805662,-0.042081457,1.718275e-33,0.005263404,0.033045735,0.03171205,0.02688975,-0.06774828,0.0775387,-0.13045417,0.02702757,-0.040498234,-0.039579764,-0.07460632,-0.106720425,0.036765594,0.023041293,0.014079104,-0.058883402,0.037983783,-0.006181905,0.056851473,-0.010844689,-0.0041471818,0.03599193,0.015580948,-0.0247923,0.010268054,0.08858998,0.03431641,-0.04307453,0.11375723,-0.0009724085,0.019150605,-0.13617773,-0.004740862,-0.0049955007,0.0139674,0.052960027,0.0010347107,-0.00470252,-0.020575909,0.025929509,-0.017852861,0.020804761,-0.032948308,0.02321224,0.06189452,-0.09118157,0.008393426,0.084380545,0.0071352473,0.08335728,0.045473978,0.015844205,0.038647044,0.011199369,-0.08625522,0.04352326,-0.019760458,0.03330524,0.08320291,0.015783206,0.022766478,0.06643059,0.06233713,0.038331658,0.07532452,0.080931105,-0.0677258,-0.08919078,-0.05495664,0.087442614,-0.043340135,-0.022575863,0.042451542,0.013355941,0.034495518,-0.0006920353,-0.08997261,-0.016515555,0.05321031,-0.013694656,-0.064411454,-0.027926289,0.0435449,0.040850203,-0.038881473,-0.052825905,-0.04352458,0.02172305,0.014415062,0.05402337,0.10526359,-0.107789494,-0.007899088,0.08736857,0.013575016,-2.459896e-33,0.053401694,-0.099188775,0.074690916,-0.05314004,-0.06444979,0.11200623,0.06587958,-0.12809116,0.01915333,0.03981822,0.07717099,-0.0015466365,-0.019811803,-0.06705437,0.036337953,-0.016788948,-0.024643084,0.07640227,0.02410493,-0.0014743926,0.04279532,0.08243225,0.008851797,0.06422364,0.053105544,0.043259982,0.07759235,0.043224912,0.025214974,0.01819778,-0.06413125,0.025450462,-0.03833369,-0.03710286,-0.05138217,0.109447986,-0.02074419,0.0027596636,-0.049275156,-0.0054162685,-0.04844953,0.054385804,0.051161155,0.0770839,0.025845427,0.08265442,-0.033578046,0.079629585,0.005300877,-0.03222399,0.0066687036,-0.03977737,-0.053226657,-0.039302237,-0.021125956,0.0033366121,-0.028604424,-0.0014625532,-0.03762674,-0.032545228,-0.011757633,-0.05930031,0.03678375,-0.041070968,0.009542488,0.0003326576,0.023284346,0.014830211,0.038755074,-0.025342371,0.06933269,0.026372537,0.06345856,0.010856662,0.01640646,0.024859747,-0.0038443275,-0.056657813,0.076666534,-0.0752221,-0.0319073,0.028734373,-0.006674155,0.0002730292,0.009786473,-0.06938791,0.007118001,0.120321006,0.08697592,0.061784264,-0.03343566,-0.022597168,-0.03867992,0.028652651,0.0656621,-3.4209982e-08,-0.01074436,-0.09860348,0.08257111,-0.06887245,0.018078627,0.034118913,-0.009410127,-0.06994435,0.0757555,-0.09087455,-0.019189565,0.01606428,0.0036501659,0.02995236,0.00078699616,-0.042749345,-0.013336983,0.058889333,-0.049201097,-0.08693269,-0.114283115,-0.075520135,-0.120071255,0.032691468,0.036071364,-0.13117497,-0.03334549,0.087391116,-0.044440407,-0.022725873,0.0076382365,-0.029604698,0.0034954245,-0.0143217025,-0.05004579,0.07013415,-0.001913344,0.01634861,-0.04558715,-0.039265435,-0.02539997,-0.06773515,0.0592399,-0.065952696,-0.05108985,-0.030964732,-0.025126437,-0.0076600867,-0.028240612,0.0384674,0.043470755,-0.067914434,-0.032115314,-0.06910002,-0.07656528,-0.033050507,-0.003135925,-0.10492907,0.011805311,-0.09629024,0.024109231,-0.027197095,0.08899098,-0.055806648 +4.2.3.91,"Requires Mg2+. The enzyme gives 28% cubebol, 29% (-)-germacrene D, 10% (+)-delta-cadinene and traces of several other sesquiterpenoids. See also EC 4.2.3.75 (–)-germacrene D synthase and EC 4.2.3.13 (+)-delta-cadinene synthase.",384,0.99999994,0.007875116,-0.08278674,-0.07060874,0.017200798,-0.009112907,-0.049540427,-0.0017599999,0.08823522,0.015767787,-0.025039585,0.00882873,-0.07470183,0.0031078095,0.01587972,-0.0075726765,-0.042266577,0.04609178,0.03407319,-0.024264514,-0.026200077,0.09746909,-0.010930672,0.015616115,0.018982423,0.10416394,0.0029792583,0.061895795,-0.05832345,0.054013543,-0.053385556,-0.028485604,-0.019393427,0.054761786,-0.09777418,0.061081782,0.0141996825,-0.07032391,-0.005401759,0.019759793,0.034395173,0.04636731,0.016334679,0.061719403,-0.022355484,-0.045029625,-0.105937496,0.005768234,0.013968189,0.022630252,0.08545891,-0.032826398,-0.081719995,-0.095051445,0.006810531,0.017447952,-0.059603203,-0.06111548,-0.005798121,-0.009531196,0.030403774,0.007062242,0.039005954,0.01623114,-0.056273613,0.038505815,-0.021469915,0.025958177,-0.06367349,0.010380603,0.004874315,-0.03934615,-0.05029638,-0.030245842,-0.0012265875,-0.04420002,0.019546052,0.033564914,-0.031983998,0.06512206,-0.037669323,0.02762759,0.04295185,0.06565894,0.109882005,0.06974316,0.056087643,-0.010339322,0.07373249,0.033286184,0.067839466,0.13722488,0.04019654,-0.05413285,-0.037053138,-0.024820484,0.07926586,-0.02951716,0.042770837,-0.025060173,-0.036152266,0.019540144,0.09181513,-0.060582522,-0.03223413,-0.053795062,0.053908188,0.0072563407,-0.0016841493,0.02299027,0.011577823,0.056510296,-0.01439794,0.035699025,0.016721811,-0.0388265,0.099966064,0.031540293,-0.08352678,0.004480633,0.0055488083,0.011396685,0.0071805674,0.024323795,0.039717436,-0.016643079,0.047256432,-0.015037615,2.6002196e-33,0.03679069,0.071049415,0.041059535,0.06566327,-0.094991885,0.056561317,-0.07139272,0.07199636,-0.068021566,-0.06839273,-0.16115117,-0.10681927,-0.00923616,0.061572436,0.0032781984,-0.014558791,0.043998517,-0.057597574,0.07291244,-0.04235048,0.010768851,0.0001615949,-0.049249038,0.023756342,-0.010322146,0.085129626,0.028118234,0.047289103,0.05158254,-0.012980811,0.012686548,-0.082126275,-0.02295378,-0.016677868,0.0008412667,-0.0144432625,0.009723186,0.013704962,-0.08509198,0.044438876,-0.02658715,0.07261344,-0.019211622,-0.036267836,0.059266463,-0.037729695,0.02136527,0.037344772,0.09179681,0.09498008,0.020544771,0.015573196,0.033437375,0.038305704,-0.08053553,0.017802995,-0.08642626,0.015516117,0.11721662,0.041620553,0.01810172,0.019581676,0.0120994095,0.011007402,0.043547686,0.13074817,-0.1016877,-0.047302965,-0.0659382,0.054652445,-0.05179274,-0.07498009,0.04125361,-0.0031225362,0.03558817,-0.025948334,-0.044767775,-0.017420022,0.07710318,-0.028689384,-0.06589833,-0.04370793,0.021463733,-0.030111542,-0.04712837,-0.071701586,-0.017141674,-0.0060498514,-0.0412009,0.055825967,-0.0036293948,-0.093767725,-0.07538311,0.036740396,-0.035730693,-3.0054432e-33,-0.0056785964,-0.036993902,0.03381198,-0.047248878,-0.0702518,0.07582698,0.030812986,-0.10705432,0.074082926,0.004521364,0.054064136,0.02550615,0.036482017,-0.06290636,-0.022604398,-0.0029538686,-0.07751385,0.08971462,-0.030990032,-0.006847223,0.010833794,0.07376894,0.011314889,0.09121606,0.056263607,0.060582858,-0.0014658272,-0.016904706,0.033959497,0.08001198,0.022129068,0.02072246,-0.04886681,0.03463742,-0.12989055,0.03606843,-0.036188837,0.035572883,-0.027414838,0.06917402,-0.07216619,0.02447292,0.015815454,0.10260395,0.098100625,0.01223815,-0.04369258,0.005428847,0.039889157,-0.05161298,0.01764187,-0.0050866813,-0.03234441,-0.0018231786,0.034633484,0.017712357,0.0075106807,0.01681901,0.029372925,-0.06619068,-0.028603878,0.0032994659,0.0145745175,-0.13751298,0.045849815,0.04555277,-0.0033329644,0.0912944,0.04799011,0.023791978,0.06931008,0.049099095,0.044546213,-0.017364882,-0.029637858,0.0036396526,0.014097569,-0.052455366,0.051558148,-0.06146721,-0.018556457,0.01718371,0.024817662,-0.06940656,-0.07061423,-0.082311,0.03954613,0.049304076,0.0398699,0.0661842,-0.09372813,-0.039678145,-0.033798102,0.06989923,0.08975662,-4.492713e-08,-0.011375233,-0.008413109,-0.0043588704,-0.037054587,0.022623632,0.04277558,-0.030112235,-0.022754064,0.029415898,-0.0018496074,-0.0065218327,-0.005925833,-0.062632196,0.024094446,0.040409114,-0.037771862,0.0034227239,0.060602844,-0.06372656,-0.035323057,-0.026645612,-0.041323215,-0.10103791,-0.015261375,0.024755886,-0.1472216,-0.027393563,0.031461377,0.0062837056,0.016384471,0.018872727,-0.03799379,0.025154978,-0.011757522,-0.077462845,0.01772681,-0.047451224,-0.019254267,0.0033768741,0.0007997808,-0.019876132,-0.100872986,-0.009027443,-0.024610115,-0.027728664,-0.0062104035,0.0013777149,-0.0100820325,-0.020605471,0.061403748,0.03386576,-0.080719605,-0.07665549,-0.02301104,-0.030184666,-0.0032839798,-0.02237844,-0.04071049,-0.048647244,-0.13894215,-0.0080233915,0.003070674,0.11416126,-0.027175577 +4.2.3.92,"The cloned enzyme from the melon, Cucumis melo, gave mainly delta- and gamma-cadinene with traces of several other sesquiterpenoids cf. EC 4.2.3.62 (-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]; EC 4.2.3.13 (+)-delta-cadinene synthase.",384,1.0,-0.05367216,-0.04035115,-0.07436059,-0.04803592,-0.046532746,0.034540743,0.0045451485,0.0596555,0.060309302,-0.058475804,0.09248489,-0.08621592,-0.004242809,-0.071830235,-0.024112007,-0.039748333,0.006159636,0.044794556,-0.041187137,-0.035819735,-0.00035273074,0.011244777,-0.025327163,0.026644433,0.06469279,-0.029281732,0.044190854,-0.10953358,0.031081518,-0.12447462,-0.04523435,0.02778931,0.000406957,-0.013513152,0.0996327,-0.006842909,0.003727011,-0.049031675,0.027376702,-0.038714346,0.10108628,0.030305257,0.08758319,-0.057909325,-0.0912457,-0.038986463,0.029361222,-0.003509923,0.044224244,-0.015496897,0.00055612123,-0.08114226,-0.027288517,-0.008408593,0.026325209,-0.021467011,-0.042276815,-0.023790115,0.01820262,0.06381512,0.0050532813,0.05930811,-0.0017008103,-0.009128882,-0.05643047,-0.04622697,-0.013259775,-0.024234207,0.04453375,-0.045260906,-0.08005389,-0.009774861,-0.06533666,0.024138704,-0.06315754,0.13020289,0.02157257,0.042823277,0.018225998,-0.101418674,0.0096781645,0.042794377,0.079801224,0.06519913,0.0040258435,0.03255222,0.021534607,0.060680494,0.09552351,0.049441844,0.119496465,0.05924161,0.004678957,-0.08331949,-0.08818841,0.063819036,0.042403918,0.048816822,0.05061857,-0.014956048,0.05096714,0.0898961,-0.016282978,-0.007452928,-0.035205606,0.030623732,-0.077700116,-0.03787367,0.029887386,-0.06831503,0.085150786,0.0036164834,0.0421959,0.0044507883,-0.04330002,0.037347913,0.0055726413,-0.025511207,0.005422183,0.012302557,-0.02937161,0.00023412518,-0.00598724,0.0076808045,-0.015264688,0.070016645,-0.023927683,1.0673341e-33,0.056057982,0.11524517,0.06457367,0.060567506,0.0015049003,-0.024154477,-0.109917276,0.057280425,-0.094114386,-0.11911735,-0.122609876,-0.012312039,-0.043316204,0.046455555,0.0048017404,0.016518578,-0.0063873366,-0.026513329,0.022007398,-0.08047428,-0.03151624,0.056423496,-0.040104188,-0.03891714,-0.014050323,0.046206668,-0.009419703,0.01947314,0.034976326,-0.022387953,0.0062812543,0.008720977,0.019065492,0.051119007,0.019198257,-0.0032844355,0.034911864,-0.05355416,-0.048528865,0.034362283,0.059137862,0.016154954,-0.0708536,0.0015957159,0.015128512,-0.09802381,-0.040079538,-0.01426624,0.094609655,0.00031053898,-0.05078119,0.029838769,0.120006934,-0.010261573,-0.028685719,-0.022304453,-0.0045323162,-0.04951835,0.03201956,0.078319594,0.01396778,0.062014807,-0.09533542,0.01775923,-0.001008262,0.10911466,-0.08686638,-0.01843927,0.008432694,0.07176328,-0.055695035,-0.022655187,0.040922698,-0.05345147,0.106696114,-0.027607901,-0.06743215,-0.004112457,-0.018060649,0.011089304,-0.028905958,0.0059930636,-0.022282133,0.0009841466,-0.04425189,-0.06848287,-0.028602436,0.06908655,0.016748156,0.056358784,0.04848134,-0.03850776,-0.064352795,0.027410446,-0.06695576,-1.9038022e-33,-0.0056137424,-0.050337788,0.014892347,-0.03092603,-0.044414587,0.023840623,-0.00058027584,-0.03541406,0.03136016,-0.040268768,0.05163337,0.010786785,0.06647833,-0.0671553,-0.015664063,-0.0039836704,0.0315671,0.12276262,-0.07896512,-0.043306038,-0.0676818,0.028868599,0.031169392,0.06677065,0.036075026,-0.0102339005,0.015387482,0.01194083,-0.028811404,0.075894356,0.043716174,-0.035545006,-0.002488394,0.026815264,-0.0793726,-0.022791887,-0.01326243,0.04791146,0.042555146,0.054812726,-0.0424914,0.029043667,0.027540034,0.060934823,0.09691448,0.07025458,-0.10242175,0.02114849,-0.06345417,0.037249602,0.06579481,0.006981569,0.012771539,0.018049974,0.014088618,-0.014557487,0.012944213,0.015628833,-0.017383777,-0.0045332685,-0.06898163,-0.082623854,-0.019546347,-0.062024817,0.073754236,0.057459664,-0.0027257972,0.13393542,-0.005363199,-0.041548725,0.08774503,0.035375915,-0.0016079792,0.005976139,-0.02534097,0.026941773,0.017545456,-0.08548649,0.011458228,-0.04494295,-0.03516281,-0.006057894,0.049476303,-0.07916964,-0.032681637,0.02990493,0.01327678,0.08479758,0.07225224,0.074084446,-0.06561775,-0.014208758,-0.043181993,0.104793146,0.11822352,-3.8754518e-08,0.041699164,-0.023040114,-0.032284785,-0.0012816088,-0.0030683323,0.00067337346,0.03062128,0.061402995,0.034157097,0.00874041,-0.027561503,0.04800479,0.009394186,0.015293166,0.03245617,0.039024685,0.029817458,0.01699633,-0.012605008,0.05121004,-0.03582841,0.0008220785,-0.017137669,0.006459834,-0.045300186,-0.12939852,-0.03480391,0.04390596,-0.006235944,-0.04278295,0.04679668,-0.001484168,-0.008758829,-0.024118176,-0.077746175,-0.008900115,0.0017055767,-0.09112231,0.065747075,0.06078684,0.00723316,-0.07131693,-0.077704296,-0.0039052172,-0.03395121,0.016326495,0.01825605,0.006927057,-0.040915273,0.044665728,-0.036949843,0.011837708,-0.015000385,-0.07425339,-0.075757615,-0.093143225,-0.021995645,0.00023581058,-0.043768782,-0.045932993,-0.021524182,0.013330644,0.17368099,-0.0068491236 +4.2.3.93,"Requires Mg2+. In Aquilaria crassna three clones of the enzyme gave about 80% delta-guaiene and 20% alpha-guaiene (see also EC 4.2.3.87). A fourth clone gave 54% delta-guaiene and 45% alpha-guaiene [2]. +The enzyme from Pogostemon cablin gives 13% delta-guaiene as well as 37% (-)-patchoulol (see EC 4.2.3.70), 13% alpha-guaiene (see EC 4.2.3.87), and traces of at least ten other sesquiterpenoids [1].",384,0.99999994,-0.040927034,-0.09272122,-0.08834974,0.0024904017,0.026124572,-0.032055072,0.06357174,0.07014853,0.040038303,-0.046529196,0.061178822,-0.0486232,-0.030867504,-0.025706079,-0.039320085,0.003721235,0.035991482,0.01357179,0.040155087,-0.053298153,0.029899023,-0.038351152,0.015143113,0.0052125663,0.024083253,0.014652922,-0.030142419,-0.064110644,0.065331236,-0.06524143,-0.017102486,-2.1189975e-05,0.053890117,-0.027543047,-0.04292835,0.067504086,-0.06996326,0.0019601232,0.032920975,0.016027868,0.049655925,0.06121906,0.038554907,-0.030614307,-0.04135529,-0.0925532,0.027848138,0.008960632,0.023969304,0.06542939,0.0028254057,-0.06364405,-0.08933387,0.027801922,0.00915269,-0.03300058,-0.08627532,0.014201286,-0.01842036,0.04754691,0.031534396,0.04462074,-0.006459427,-0.058584157,-0.031550467,-0.028675538,0.0072973017,-0.039133552,0.03424399,0.010280194,-0.014432629,-0.01724566,-0.0379236,-0.049171485,-0.109919295,0.115279764,0.026663192,-0.015254352,0.01956332,-0.008177683,0.0039315145,0.010878614,0.07237946,0.12159738,0.06403096,0.05473565,0.005813018,0.041876882,0.052567963,0.048616443,0.16168596,0.0759952,0.005209238,-0.03280923,-0.008036149,0.11000299,-0.04480668,0.027214581,-0.058584463,-0.03264876,0.03220442,0.029128507,-0.046374068,-0.065111905,-0.076104514,0.05366407,0.0054096845,-0.046042528,0.040116012,0.005398712,0.00055165566,0.03355827,0.040916573,0.037737433,-0.00810348,0.06365801,0.038493387,-0.01378635,-0.003092261,0.0272416,-0.014950378,0.022315102,-0.0025032018,-0.036264885,-0.0445439,0.036228705,-0.015114873,5.2255628e-33,0.038475417,0.06684308,0.064157434,0.026252167,-0.014998821,0.017067758,-0.092039235,0.053716775,-0.056076042,-0.063026994,-0.16202675,-0.07527007,-0.035462305,0.040768247,-0.022464275,-0.016862327,-0.0048692636,-0.08125543,0.10100992,-0.04526297,0.015247338,0.0093404185,-0.06564553,-0.034697775,-0.0063338107,0.040914364,0.020353815,0.011134518,-0.03672267,-0.015923202,-0.008208645,-0.07074591,0.010912513,0.018271266,0.0064244773,-0.025762178,0.016947113,-0.026582688,-0.08655281,-0.010905742,-0.020132706,0.04499037,-0.0228081,-0.013595013,0.04966844,-0.10316465,-0.0021647566,0.056622483,0.09479711,0.07890268,-0.032085888,-0.018041348,0.024309356,0.024090165,-0.12230654,0.019818226,-0.022620937,0.012557279,0.07894586,0.08279418,0.023281094,0.015081572,0.0412065,-0.046600956,0.071249306,0.14089154,-0.09989223,-0.037982196,-0.0393016,0.067995176,-0.005391788,-0.056197826,-0.04541938,-0.03996368,0.1044128,-0.04324398,-0.0304332,0.0053358767,0.052351046,0.0045024655,-0.09816251,-0.040937554,0.04134244,0.032428835,-0.103262536,-0.042246774,0.015717804,0.09319011,0.061476473,0.06806024,0.05232168,-0.08510855,-0.04215448,0.017286416,-0.03998971,-3.49021e-33,-0.00724324,-0.07186456,0.05801351,-0.03094038,-0.06973232,0.076876596,0.038151663,-0.04829243,0.03666934,-0.0014728125,0.02828626,0.017301656,0.0005285144,-0.0829245,-0.023050245,0.021429673,-0.0015750902,0.08246778,-0.029800797,-0.05009713,-0.036587004,0.05422204,0.06262237,0.08627159,0.03143981,0.042079043,0.07787156,-0.020912401,0.007827318,0.06340408,0.014664511,-0.0138119785,-0.048636682,0.045591544,-0.09165514,-0.02144798,0.00064016297,0.046421606,-0.023839673,0.032266807,-0.0069010225,0.03986388,0.026978442,0.102424815,0.07547173,0.04518205,-0.094977826,0.019584937,-0.03186364,-0.07030426,0.042050745,0.019423254,0.019206336,0.022175295,0.055476923,0.007421315,-0.04753608,-0.01968469,0.021594819,-0.011043031,-0.027638622,-0.05104529,-0.107404016,-0.05448048,0.09818807,0.045038074,0.0012654682,0.11971739,0.02162332,-0.011186672,0.05147997,0.017286783,0.046368655,-0.005338237,-0.031979613,0.021325875,0.019005038,-0.04879192,0.06566058,-0.06092449,-0.013034337,0.006875182,-0.04290394,-0.10273205,-0.065940216,-0.0632523,0.027909474,0.09143424,0.10934843,0.05918545,-0.042394646,-0.01981028,-0.06628155,0.05863517,0.12179728,-4.7629012e-08,-0.0031786333,-0.02344896,0.033624835,0.017612925,-0.0085184295,0.054893963,-0.0032468534,0.029427094,0.026338186,0.010881912,0.00577045,0.013862443,0.020291073,0.040036805,0.007478089,-0.0046915524,0.051424414,0.071639016,-0.008764676,0.0039689806,-0.04627765,-0.024058374,-0.12284794,-0.017123511,0.020785999,-0.087875284,0.0018528494,0.06443451,-0.026951661,0.047923956,0.02507279,-0.05424398,-0.004897192,-0.030180259,-0.052785575,0.04007166,-0.039152205,-0.046789397,0.0031297856,-0.007509031,-0.039193347,-0.054745104,0.0149333645,-0.022213914,-0.03243074,-0.0064871036,-0.008317693,0.0032067325,0.027594965,0.060506303,0.08983985,-0.05455622,-0.010130686,-0.051857147,-0.09188071,-0.08734746,0.0032918875,-0.05998646,-0.028436389,-0.13637474,-0.020833382,-0.015741922,0.06798535,0.0035116265 +5.3.2.4,The enzyme is involved in biosynthesis of D-mycaminose. 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+5.3.3.18,"The enzyme catalyses the reversible isomerization of 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA to the unusual unsaturated, oxygen-containing, seven-member heterocyclic enol ether 2-oxepin-2(3H)-ylideneacetyl-CoA, as part of an aerobic phenylacetate degradation pathway.",384,1.0,-0.04478391,-0.026744552,0.029749602,0.009419859,0.12811644,-0.035875335,-0.053372253,-0.06592413,0.025306001,-0.052220963,0.04697802,-0.04505502,-0.063350536,0.042903427,-0.025263842,0.03042309,-0.121733055,0.034266353,-0.039551754,-0.005311206,0.043180685,0.00081332243,-0.018128252,0.071552865,0.05202361,0.025345458,0.019661725,0.026305508,-0.03504218,-0.13232692,0.08323071,-0.019341284,0.012474837,-0.03654815,0.007154195,0.018479856,0.04946004,-0.025250986,0.05670895,-0.01976895,-0.028619347,-0.050251275,-0.047481652,-0.06792543,-0.04058112,-0.07814134,-0.014554835,-0.0026601043,0.035131093,0.0033558817,0.074839585,-0.03913998,-0.05683199,0.054994356,0.021915749,0.015618887,-0.034580644,0.034380913,-0.06654849,0.029019931,0.07452772,0.03828321,-0.045405824,0.03636794,-0.10516245,-0.066999696,0.024332589,-0.05275233,-0.004799571,-0.011696797,-0.06463567,-0.118043326,-0.0034603507,0.08128544,-0.008290296,0.06659253,-0.017632931,-0.042568628,0.0030319798,0.02566542,0.049713492,-0.021610845,0.0045803026,0.06676734,0.05992123,0.022747803,-0.03837306,-0.06530984,0.021380844,-0.034957983,0.016392969,0.026619636,0.064298704,-0.00841373,0.06746736,0.09246195,0.018315325,0.02598168,0.02345195,0.07983353,-0.012773413,0.081368215,0.012183503,-0.1301387,-0.0020190084,-0.01733773,0.061549608,0.02537254,0.0559666,-0.056794327,-0.0153089175,-0.05697771,0.09582521,0.026911965,-0.029599614,0.085777886,-0.008764081,-0.00526044,0.0054331287,-0.028870115,-0.011052003,0.023422584,0.06471207,0.07053326,-0.03194737,-0.01485417,0.021371864,3.890183e-33,0.017906515,0.0046052416,0.030652676,0.019614832,0.018449808,-0.07498065,-0.04824839,0.040398173,-0.017680842,0.0108859725,-0.073808804,-0.019196626,0.055403877,0.060307547,0.0075095184,-0.0685322,-0.0027778263,0.07283763,0.040001653,-0.06731569,-0.018966215,0.0032946486,-0.059362773,0.011449168,0.008328248,0.016389979,-0.021588823,0.017358765,0.108665004,-0.00036927385,0.04366216,-0.019345134,-0.08238055,0.00443112,-0.05503313,0.0010637874,-0.032910373,0.033147488,0.0046672677,0.07456577,0.079148635,0.012545663,-0.05391556,-0.08358896,-0.0008585666,-0.034811933,0.03001254,0.11268143,0.006442616,-0.049165323,0.049218018,-0.008132806,0.0038968257,0.020485284,-0.0013444753,0.04551121,0.042137787,0.017101953,0.06898596,-0.029599283,-0.012876806,0.13519728,0.017903361,-0.013081903,0.023624135,0.01343247,-0.04064263,-0.0019374988,-0.08028465,0.038043782,-0.050093032,0.025891347,0.018781267,-0.030400155,0.12873675,-0.07277991,-0.052737623,-0.0135753015,0.10576257,0.001791939,-0.0065609273,0.023489844,-0.017011262,-0.013805129,-0.062354833,-0.0155554,-0.016674992,0.064384565,-0.03249392,0.098395705,0.053076513,-0.06901929,-0.013864473,0.024743559,0.030848023,-3.785317e-33,0.053402513,-0.09490133,-0.005800063,-0.09495503,1.8003913e-05,0.024412267,-0.013979452,0.02670311,-0.039579187,-0.0030861723,0.080120236,-0.024040328,0.00029539544,-0.013335548,0.042087037,-0.024250763,-0.021578217,0.0111984275,0.01894435,-0.0048859944,0.040081635,-0.015876995,0.026858812,0.0046319473,0.055724338,0.043688547,0.046796527,0.021257218,0.12541364,0.08292217,-0.055651955,-0.0597707,-0.002839282,0.029586617,-0.039440505,0.10792301,-0.101172894,-0.014078954,-0.03578344,-0.04346787,-0.108717024,-0.012071752,-0.036341127,0.0003833917,0.08956818,0.0016663794,-0.06580717,-0.03008243,0.025778404,-0.064280204,0.029230058,0.06962693,-0.0778803,0.0050783814,0.019464463,0.10651004,-0.071794294,-0.027004566,-0.012444779,-0.083242275,-0.0688918,-0.060793024,0.00031067818,0.039258376,0.03840015,0.054401603,-0.07519218,0.14583218,-0.049733162,-0.071722575,0.070104636,-0.05169888,0.044850413,0.01937154,0.045388103,-0.114405796,-0.02116216,-0.03368592,-0.04236813,-0.021438543,-0.04422078,-0.06876026,-0.05183022,-0.07638314,-0.095821045,-0.10337078,-0.032770272,0.038042627,0.014817064,0.060601853,0.03907336,-0.034521885,-0.037546623,0.09658496,0.088398516,-4.444748e-08,-0.0032636807,-0.09299868,0.09320245,0.01269466,-0.023042865,0.054911107,0.040411122,0.03990525,0.053668156,-0.072937556,0.014158348,0.081113026,0.04202388,0.0672855,0.001938676,0.006299293,-0.047863945,0.04064157,0.03128792,-0.022083312,-0.05060313,-0.027427737,-0.037403576,-0.0050465968,0.015331578,-0.043560285,0.010433307,0.066380866,-0.0444476,-0.046625763,0.010613286,0.0689956,-0.012977512,-0.013308405,-0.025167283,0.00011268899,-0.04279496,-0.007908195,-0.08178488,0.039535392,-0.05488199,-0.0034059475,-0.09597522,-0.009025091,0.070462756,-0.042671613,0.048389763,0.048702914,0.0061261756,-0.069254234,0.045184128,-0.041302465,0.0016999963,-0.016310932,-0.045279752,0.013475519,-0.027739033,0.015170508,-0.010337724,-0.03181784,-0.024904648,0.017018864,0.14683382,0.0026262905 +5.4.4.5,"The enzyme contains heme [3]. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P-450 heme thiolate domain [3].",384,1.0,-0.04744214,-0.016196381,-0.12698576,-0.04471448,0.1059875,-0.0043637906,-0.09796398,0.04101883,0.03368859,-0.07567564,-0.0016394545,-0.021483107,-0.059873942,0.02479026,-0.036413062,0.017394856,-0.009162611,0.029477514,-0.028150199,-0.019791763,0.10083781,0.062027797,0.010445936,0.026512112,0.03508595,-0.032172665,0.13222787,-0.049151506,-0.044020742,-0.14291161,-0.01742544,-0.036550887,0.042941574,-0.05152817,0.023299523,0.046444234,-0.05544458,-0.073811665,0.03370736,-0.010812077,0.037733085,-0.06501338,-0.030461378,-0.08054691,-0.07294474,0.017114533,0.005266171,-0.025713572,0.033398204,0.044470724,-0.0034539085,-0.055112533,-0.026316289,0.014789744,-0.010978077,0.012133228,-0.008833594,-0.029274533,-0.023117075,0.008227966,0.019265926,-0.0013030742,0.00047952327,0.034703523,-0.044159822,-0.06597416,0.05276682,-0.059571035,-0.10511547,-0.13218527,-0.008701483,-0.051530387,-0.005684393,-0.01964968,-0.006878135,0.09110542,0.014335963,-0.015082171,0.05021274,-0.010013032,0.051258832,0.046176028,0.0038236743,0.12566243,0.013547709,0.018584356,-0.055313844,0.023996832,-0.0044163885,0.004155614,0.027738096,0.051435146,-0.039635487,0.016301315,-0.048327602,0.06589298,0.076831385,0.12278957,0.0012311551,-0.035603613,0.018531641,0.045150835,0.03694276,-0.04805013,-0.015810251,0.012522126,-0.0152569795,0.0733947,0.10539112,-0.010843635,-0.014482042,-0.052950967,0.08299124,-0.023096086,0.010524517,-0.0094930725,-0.0037755053,-0.04229567,-0.0038692579,-0.011806316,-0.005425019,-0.010555592,-0.009608227,-0.026004802,-0.019847782,0.045749996,-0.006708338,5.5065438e-33,0.055767,0.022847889,-0.061077174,-0.0027407124,0.018017398,-0.0037010065,-0.07819437,-0.010565437,-0.05078173,0.014507745,-0.06985549,-0.019177081,-0.0048853867,-0.03464092,-0.03427956,0.006572433,0.013142473,0.007626473,0.054895587,0.03850898,0.026635516,0.040564768,-0.092376165,0.04120171,0.01982838,0.060003255,0.01862543,-0.0038920525,0.003715505,-0.030634617,-0.004707825,-0.014404057,-0.05920004,-0.026850486,0.0843531,-0.012935711,0.041141167,0.05352597,-0.10609531,-0.00031187807,0.022580262,0.03487844,-0.03229822,-0.085121006,0.054138493,-0.081819214,-0.055165417,0.120496966,0.10456748,0.070319295,0.05514063,0.024506796,0.12499016,0.04292175,0.016272834,0.00036323085,-0.0215807,0.014667636,0.072044484,0.01994557,0.032877147,0.058598354,-0.035578363,-0.002351491,0.07805319,0.02060688,-0.10436453,-0.027459767,0.0733985,0.002008531,-0.023996985,0.051954832,0.0063342517,0.023407402,-0.0045153755,-0.0758741,-0.07088864,0.041610952,0.11107099,-0.019067412,0.08903282,0.054313663,0.03695797,-0.026720673,-0.05974276,0.026540091,0.002354639,0.008032691,-0.10068121,-0.0030184656,0.008641368,-0.075657144,-0.017255167,0.013689567,0.048349794,-5.7279562e-33,0.16827142,-0.104157284,-0.010673455,-0.08787074,-0.011572178,0.06069342,0.022477305,-0.016680758,-0.014495404,-0.016066201,0.0798285,0.004645657,0.04860799,0.015015713,0.07578608,0.021610642,-0.0003527832,0.076747224,-0.045023,-0.0432416,0.005103294,0.03652659,-0.05941143,0.06844644,0.04542246,0.018024227,-0.04675214,0.0018557204,0.03698646,0.082618676,0.005767401,0.018066725,-0.044339236,-0.011576102,-0.0052240267,0.028850138,-0.012853434,0.084633015,0.020021511,-0.0062193004,-0.022751573,0.005180078,0.023958182,0.02789782,0.01266579,0.081280254,-0.1369738,-0.0035022048,0.026333649,-0.055511937,-0.013778242,0.022209946,-0.050947517,0.01792677,0.02887809,0.0030896408,0.011259489,-0.010588268,-0.0085456865,-0.15373452,-0.08038617,0.017847743,0.010728554,0.018872652,-0.030887417,0.08121063,-0.1209113,-0.02034146,0.027290856,-0.03149723,-0.024104767,0.020802876,-0.005362638,-0.026905939,-0.0022680496,-0.054129723,0.03762957,0.0054704645,0.017647836,-0.0016074858,0.024291484,-0.04790982,0.017591296,-0.07773785,-0.02886094,-0.06413611,0.049424343,0.060279377,-0.005710152,-0.026641421,-0.0027853854,0.025936138,-0.08433229,-0.003495277,0.05303268,-5.0136773e-08,-0.02682015,-0.04373248,0.022583032,-0.051238008,-0.02801223,0.017593456,0.038949393,-0.021711284,0.111415595,-0.013899334,0.012868619,0.10426849,-0.05532017,0.014901813,0.06797897,0.0015454572,0.0021185756,0.04794636,0.033579182,0.009892739,-0.05703298,-0.016752059,-0.024747897,-0.05251581,0.03558792,-0.07488033,0.0026689593,-0.06990164,0.05107209,0.07601658,-0.055744957,0.064801484,-0.008105401,-0.09421815,0.055079352,-0.020646604,0.058339864,-0.0038626231,-0.046763495,0.012563601,0.027763171,-0.05850708,-0.09710724,-0.046719402,-0.005314224,-0.050414912,0.03984945,0.038596995,-0.024654614,-0.004681056,0.0008540712,-0.03055611,-0.04342765,-0.0308764,-0.0705064,-0.03867702,0.037090994,-0.056027923,-0.08812459,-0.018370995,0.006229185,0.020523952,0.21967049,-0.010062304 +5.4.4.6,"The enzyme contains heme. The bifunctional enzyme from Gaeumannomyces graminis catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is then isomerized to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate [3].",384,1.0,-0.056191105,-0.006181587,-0.10897203,-0.036343917,0.10627539,0.021069312,-0.02442184,0.03821128,-0.003322431,-0.015225045,-0.0058743726,-0.013834381,-0.07008323,0.022565797,-0.06903341,-0.012598293,-0.027280273,0.018186266,-0.03893538,-0.019377105,0.090819225,0.056514513,0.012479612,0.007799542,0.08820795,-0.008997141,0.12784062,-0.07353685,-0.04324431,-0.08854372,0.04714816,-0.030773861,0.07521359,-0.029177777,0.010643346,0.018432578,-0.026366178,-0.08472971,0.06156821,0.033340137,0.004559476,-0.019141361,-0.039045695,-0.029656984,-0.056648523,0.006307923,-0.0030413712,-0.016301835,0.016180959,0.044935845,-0.014108605,-0.09422619,-0.078469776,0.034257673,0.00079211174,-0.032996964,-0.04525241,-0.038269363,-0.052719347,0.030866442,0.044853244,0.0077631027,0.009449228,0.08012654,-0.05808658,-0.07241345,0.057946477,-0.060909923,-0.035393275,-0.107474566,-0.0131292725,-0.06686205,-0.050161596,0.0002650874,-0.09114602,0.04668449,-0.006523928,-0.045112822,0.062816635,-0.008630514,0.035054397,0.000118948265,0.038441982,0.15733838,0.04567371,0.020551587,0.007640684,0.04403844,0.011441112,0.027385166,0.08267373,0.044039734,-0.005174437,-0.049208384,-0.032126732,0.049212754,-0.0024306364,0.076879114,0.004307011,-0.015944066,-0.008588981,0.03389572,0.025353016,-0.07881604,-0.104314886,0.050666265,-0.038140073,0.047584124,0.059361834,-0.011820134,0.000455057,-0.042373054,0.06206065,-0.0072239134,-0.052328218,0.037219424,0.04625118,-0.08792631,-0.0695983,0.014897071,-0.022849746,-0.03784526,0.0164108,0.028900484,-0.037611507,0.06316675,0.004719119,4.3109206e-33,0.011749217,-0.014320484,-0.02039788,-0.05798704,-0.0062216586,0.0301431,-0.06779242,0.03697305,-0.06266205,0.015691409,-0.08962629,-0.010274395,0.036345314,-0.03466918,-0.020954004,0.07101119,0.0064449813,-0.0070216744,0.08279379,0.027544145,0.019340651,0.028652113,-0.059238665,-0.009071079,-0.022450322,0.066586226,-0.012141481,-0.021042718,0.033572618,-0.01657146,0.017192481,-0.08440921,-0.0869284,0.02941246,-0.020379163,-0.03494811,0.005489039,0.0048057865,-0.068372905,-0.0045937826,-0.017172314,0.04287246,0.03375882,-0.039158083,0.040481284,-0.054542027,-0.039635,0.09195279,0.14792779,0.08044159,0.009685809,-0.0021592302,0.09616845,0.043383103,-0.015609003,0.07820946,-0.022516103,0.006767462,0.09917943,0.05028478,0.051224604,0.095085,-0.0050440463,-0.020323977,0.08370012,0.03110432,-0.059430726,-0.021678658,-0.007837488,0.037019588,-0.017854173,0.007563791,0.067772776,0.04525371,-0.018329728,-0.018419525,-0.040106572,-0.024647156,0.03898,0.010693495,0.04586033,-0.029955786,0.058308687,-0.021602249,-0.021607414,0.04841608,-0.074060746,0.00329389,-0.052023493,0.049054712,0.05423778,-0.09804231,-0.09419754,0.027295766,-0.011801388,-4.9240716e-33,0.1539046,-0.11516782,-0.03694347,-0.10189848,-0.0004047187,0.066359416,-0.012590531,0.008398494,-0.0063694906,0.033855535,0.106595926,0.009122394,0.034163196,-0.011891249,0.06232791,-0.00073129626,0.01052361,0.07081529,-0.014092,-0.023710368,0.040804192,0.057996944,-0.030062823,0.009437512,0.042977557,-0.01465619,-0.014629351,0.033008978,0.03521381,0.110460594,-0.00074614584,-0.03898075,-0.0679402,-0.050626207,-0.0060943165,0.027496979,0.019549761,0.05837147,0.002581085,-0.0060304445,-0.06348564,0.008089774,0.042309154,0.040384796,0.06832639,0.056781773,-0.1460347,0.021204157,-0.007566501,-0.013142998,-0.0076627387,0.054725856,-0.036642227,0.03971541,0.049552795,0.04121023,-0.016703622,-0.005308975,-0.06836965,-0.08421081,0.0009178472,-0.032994468,-0.027018186,-0.0464615,0.030245828,0.14181614,-0.13783662,0.04085148,-0.042673,-0.010133729,-0.023037054,-0.0420487,-0.045750316,0.03662479,-0.016171668,-0.034173004,0.017339004,-0.029113477,0.0426434,-0.035078593,0.059058174,-0.014435424,0.0021346204,-0.11453657,0.0025652223,-0.029252388,0.0010743986,0.079160795,0.07421696,-0.008982076,-0.025906278,0.0046165315,-0.060964115,-0.022116367,0.011614992,-4.7325827e-08,-0.054922555,-0.10165487,0.048030216,-0.08851164,0.006764284,0.006047091,0.052826554,-0.010297676,0.07049578,-0.07709706,0.037891883,0.1244614,-0.028650286,0.049429823,0.06377689,0.015279903,-0.004480457,0.02801602,-0.0050282325,-0.020290857,-0.009087726,-0.028089633,-0.007568586,-0.011967102,-0.0024275752,-0.090749994,0.010766221,-0.011439477,0.021128748,0.031926595,-0.04591934,0.060771193,-0.009548326,-0.04736603,-0.02419475,0.0105473595,0.010203372,-0.016127087,-0.03942166,-0.015874906,-0.007200139,-0.050816227,-0.10242386,-0.023935659,0.04239366,-0.014602478,0.048614454,-0.015190304,0.011432296,-0.0015308526,0.04630222,-0.02035591,-0.028278837,0.012097412,-0.050739944,-0.08769338,0.011185152,-0.059888974,-0.03811442,-0.043318383,-0.0024338868,-0.013151747,0.22353938,-0.016963892 +5.4.99.46,The enzyme gives traces of four other triterpenoids,384,1.0,-0.0029101032,-0.06908609,-0.11662981,-0.06528325,-0.016754657,0.03579602,-0.08117372,0.034069683,0.058756877,-0.009439066,0.12086372,-0.07954328,-0.033246335,-0.025176784,-0.026236296,0.01313188,-0.06769281,0.009980795,0.023815475,-0.084687956,0.044226773,0.0075914566,-0.009283321,-0.04314787,0.017738847,0.051084593,0.013323135,-0.054434467,0.011876546,-0.057691533,0.0037835396,0.030090945,-0.032971036,-0.045469332,0.030289123,0.0051316363,-0.07128409,-0.019999275,0.10067458,0.066994816,0.08887026,-0.0033938203,0.041349415,-0.034889597,-0.02518195,-0.0039173346,-0.051395014,0.057483464,0.07957703,-0.013133894,0.030610045,-0.075588845,-0.033469852,0.024939047,-0.012102728,-0.025755076,0.002469537,-0.022873454,-0.03529413,0.10099941,0.049722396,-0.026322179,0.024332626,0.003790371,-0.008379512,-0.028863864,-0.008584185,-0.033345252,0.010137452,-0.026926897,-0.039863635,-0.06934923,-0.07155935,-0.004457161,-0.07395074,0.01686075,0.0016733514,0.00032335045,-0.029915635,-0.07163393,0.025531681,0.0021729453,0.0713152,0.12694405,0.06413854,0.04779695,0.017076153,-0.02071931,-0.016161751,0.0750286,0.11124272,0.012015241,-0.0063781734,0.009109723,-0.083202876,0.0361123,0.015568268,0.048408665,-0.04930282,-0.06034738,0.024956796,-0.026915798,-0.043652028,-0.09240285,-0.056556724,0.07799989,-0.020030687,-0.043221533,0.059231352,-0.016616512,-0.0059786364,0.0038025582,0.039047692,0.013773204,0.0016046155,0.07863681,0.0592567,-0.053423632,-0.006208277,0.037370812,-0.012376238,-0.021352805,0.10704174,0.018434271,-0.009078705,0.009222272,-0.009946682,-2.360857e-34,0.04911485,0.097879834,0.0047357357,0.002207633,-0.05460408,0.0158915,-0.038865518,0.07864658,-0.051050436,-0.04424897,-0.10302764,-0.0015084104,0.0042080963,-0.023529477,-0.022396624,0.010615917,0.04394089,0.0075716595,0.05825545,-0.048128244,-0.03136561,0.0038874855,-0.061371524,-0.033300806,0.05169788,0.094712704,0.010454557,0.00077474065,0.03652334,-0.028913712,0.0080805905,-0.06469917,-0.027682869,0.058504242,0.066083066,0.018493993,0.042570684,-0.021543643,-0.10793012,0.049896214,-0.031105634,-0.016727764,0.02482857,-0.016460668,0.034105178,-0.048977867,-0.088498555,0.014653664,0.05626022,0.045606744,-0.00017408647,0.037801098,0.08873069,0.0391851,-0.10591404,0.01679619,-0.038767494,-0.0047693914,0.02907442,0.016323237,-0.00057172,0.09110148,-0.073513776,0.0018118294,-0.0025243596,0.11372412,-0.11244141,-0.09495168,0.0060425275,0.16495243,-0.07463275,-0.016224155,0.10027042,-0.023300972,0.12516557,0.0001550935,-0.054330103,0.0077530555,0.00811319,-0.015918195,-0.02759502,-0.056599613,0.07910941,-0.0069954186,-0.056346294,-0.029263617,0.020919485,-0.02248875,0.013862035,0.01729835,0.08850743,0.01301886,-0.067938544,0.0035815986,-0.03739658,-3.0281696e-34,0.028312745,-0.040163774,-0.00042538458,-0.06642211,-0.050844245,0.10937115,-0.043979898,-0.041011862,0.010471328,0.023634989,0.07556439,-0.01677518,0.009206443,-0.07792593,0.045125972,0.047435995,0.010392783,0.069259875,-0.0043159327,-0.07655352,0.0006018149,0.028479347,0.0043100975,0.051902976,-0.028022636,0.02150576,0.0663257,-0.054817308,0.026677966,0.0583528,0.025264941,-0.045032024,-0.036366086,0.037574567,-0.012629424,0.058804817,-0.022511767,0.03403097,-0.015409576,0.06415625,-0.06447748,-0.026664918,0.018887177,0.063593544,0.028767461,-0.013759454,-0.1042133,0.07208776,-0.037487257,-0.025954839,0.095420375,0.0040549017,-0.028223565,-0.015974917,0.05072786,0.041777156,0.018578526,-0.06401898,0.00447748,-0.033169385,-0.04012085,-0.045015987,-0.04277084,-0.0070761074,0.030074844,0.0064794114,0.0009660126,0.058339693,-0.0076231025,0.03119983,0.01966587,0.07755309,-0.017683342,-0.0026538065,-0.016676797,0.017592283,-0.03796731,-0.15332907,-0.0099038,-0.019579282,-0.09518198,-0.013450618,0.062151875,-0.08697985,-0.053974945,-0.08198102,-0.0010664022,0.068462625,0.057215635,0.024705393,0.027171027,0.023864519,-0.07152336,0.03276908,0.040347166,-1.7161076e-08,0.062044237,-0.016636273,0.032771602,-0.020741608,-0.0057346,-0.010385491,0.035701927,0.036915608,0.0484509,-0.025495483,-0.019424789,0.09650986,-0.03323864,0.048395462,0.12330139,0.018334204,0.005505909,-0.04093767,-0.022620818,0.031722344,-0.035561625,-0.001333201,-0.080672055,-0.01286291,-0.008577111,-0.06588263,0.05315315,0.07396376,-0.003701842,0.032764662,0.067560636,-0.0049538626,-0.028150693,-0.0427426,-0.06368963,0.02286138,-0.012979945,-0.026979467,-0.014264711,0.09856352,-0.04282682,-0.09708332,-0.101194456,0.05303656,0.028162468,-0.0040905643,0.009389704,-0.058394857,0.04419545,-0.006091928,-0.035345428,0.03553097,-0.0029857613,0.013979869,-0.074118726,-0.044064205,0.008257428,-0.041941304,-0.022970146,-0.09554294,-0.026969582,0.017542638,0.20992482,0.066671155 +5.4.99.47,The enzyme from rice (Oryza sativa) produces parkeol as a single product [1].,384,1.0,-0.026957689,-0.05558134,-0.010958431,0.0127129285,0.06161478,0.055130854,-0.0036798145,0.008795469,0.045667257,-0.040927526,0.06839981,-0.018210096,-0.046087883,-0.04730404,0.012149631,0.039775,-0.021101294,0.07549538,-0.092821054,-0.06449375,0.12017663,-0.0019320879,0.0012453657,0.026271367,-0.027532404,0.025044927,-0.01824032,-0.0111730015,0.022100989,-0.09633373,-0.031024445,0.010121693,0.058733217,-0.036225747,0.07622103,0.042589355,-0.00627922,-0.08958817,-0.00950911,0.011029886,0.055798095,-0.05994606,-0.038275015,-0.046947505,-0.03165379,-0.03950124,-0.003444251,-0.010831537,0.1009396,-0.040964995,-0.037932318,-0.013886379,-0.009893949,-0.057467807,-0.039977632,0.0042246743,-0.049965765,-0.00034394526,-0.085999355,0.049412545,0.008968954,0.0029652868,-0.0683168,-0.0033546356,0.009537717,0.0038579623,-0.09016447,-0.06652201,0.039842978,-0.018128458,-0.039646093,-0.08278705,0.034883875,0.0556783,-0.04307842,0.021092286,0.067099795,-0.014790133,0.107408956,-0.095412314,-0.008694006,0.027745621,0.007085417,0.04531369,0.04354651,0.024152441,-0.030318426,0.093719885,0.11052633,-0.010850607,0.04582107,0.019004129,-0.006196568,-0.0120140575,-0.0008348775,0.07387286,-0.019316262,-0.09654076,0.02382831,-0.017901374,-0.023766221,0.03986883,0.0028243249,-0.15476489,-0.05452114,0.0543671,-0.023696689,0.0035368204,0.0011178592,0.06711577,-0.014229884,-0.02558475,0.0329157,0.0914618,-0.1001845,0.052715883,-0.0015128998,-0.032539885,-0.03557214,-0.082983494,0.00554632,-0.08965572,0.04142663,0.09193296,-0.079679154,0.039697226,0.00077451364,-1.6669092e-33,0.019065056,-0.006328204,-0.017535195,-0.07565103,0.019168353,0.0096086655,-0.0154770035,0.033111464,0.00012990477,-0.01782765,-0.08697287,-0.07312972,-0.019485133,0.03138158,0.00032166322,0.0062063867,-0.0057587787,0.019849302,0.044690993,0.062345825,-0.0023060255,0.12754871,-0.057438284,-0.014473699,-0.017565563,-0.019976463,-0.002657475,-0.034556333,0.03816488,-0.021161059,0.03553979,-0.049687196,-0.043712035,0.0019984557,0.021184446,0.018892648,0.026565688,-0.021595765,-0.019261684,0.0944727,-0.021529112,0.040165,0.021272909,-0.0051140897,0.030708786,-0.0069722803,-0.03934855,0.09077364,0.00085875543,0.007979257,-0.021067992,0.064261615,0.041126013,0.021705093,-0.043322325,0.010951323,-0.016215583,0.011794033,0.040333584,0.06325659,-0.077792674,0.1336156,-0.010437031,0.0006482059,0.0013699093,0.005804108,-0.065783195,-0.04028308,-0.039384272,0.083778635,0.054152604,-0.041317813,-0.061413813,0.04242111,0.014010057,-0.09448057,-0.022645136,0.03906544,0.0075661796,0.03756802,-0.010722104,-0.025439221,0.028900048,0.038008176,-0.08204083,0.039044965,-0.038288,0.047703102,-0.027759392,0.0045313803,0.043228578,-0.030792367,0.0076241293,0.040218957,-0.03842848,7.756039e-34,0.009162982,-0.08278287,0.07067487,-0.02617408,-0.06257572,0.029035121,-0.042810272,-0.07765104,0.014131552,0.059953675,0.017404912,0.00852895,0.061775394,-0.05344299,-0.028974028,0.08994236,-0.0038518093,0.10772327,-0.08382941,0.07383445,-0.038395472,0.13060388,0.03477589,0.079097986,0.060561534,-0.0020002052,0.09991073,0.10575262,-0.042586565,0.03558661,0.076676734,-0.035991833,-0.06779216,-0.114269726,0.027457584,0.014587685,-0.013198836,-0.09281598,0.009350783,0.022650737,-0.009747844,0.036714908,0.038260467,0.033660915,0.0031731157,-0.02031728,-0.118161865,0.045351528,-0.03985646,-0.049416695,-0.021646475,-0.00566457,-0.0058297473,-0.024495345,0.01072224,0.00901931,0.05386218,0.00344041,-0.102140464,-0.083156,-0.014047833,-0.04602749,-0.0021053923,-0.006432642,0.071930744,0.049834386,0.025951006,0.033758003,0.0026016806,0.03309149,0.0029488131,0.011304553,0.028568905,0.09171283,-0.04656786,0.06325679,0.015727881,-0.06667029,0.052740097,-0.051265955,0.0024748964,0.0007598049,0.0030922354,-0.09691166,-0.02574389,0.0012570326,0.014122603,0.14066507,0.04662678,0.12767248,0.019929787,-0.057541125,-0.079315655,0.12661792,0.12036241,-2.3188488e-08,0.046733156,-0.10025353,0.046607222,-0.042350788,-0.096686654,-0.029945677,0.019414496,-0.019240929,0.058398493,-0.049672384,-0.054614786,0.09964065,-0.014346537,0.04788207,0.00020704725,-0.0044645444,0.06761094,0.10609114,-0.016344236,-0.033363573,-0.01536805,-0.036200147,-0.02887345,-0.009912291,0.028683592,-0.0925478,0.016109653,0.023792634,0.04547495,-0.030959962,0.018729147,-0.04133877,0.020729298,-0.017972486,0.053863287,0.06014246,-0.027105605,-0.024450377,-0.021264,0.0014750567,-0.026841123,-0.050311416,0.026348254,-0.010969581,-0.013439326,-0.057018064,0.017889902,-0.013008214,0.058254965,0.02132498,0.018541325,-0.043566853,0.03998198,-0.11093395,-0.039765738,-0.030440528,-0.045467265,-0.03133894,0.01343703,-0.0333621,-0.027651016,0.025963068,0.13938211,-0.006791451 +5.4.99.48,"Achilleol B is probably formed by cleavage of the 8-14 and 9-10 bonds of (3S)-2,3-epoxy-2,3-dihydrosqualene as part of the cyclization reaction, after formation of the oleanane skeleton.",384,1.0,-0.17819682,0.024984483,-0.067631975,0.0006401145,0.039956313,0.008854663,-0.077918336,0.017775761,0.04318587,-0.018487042,0.05273952,-0.085110106,-0.04931606,-0.07103596,0.0021070119,0.09442562,-0.10831432,0.01888577,-0.08878107,0.006684278,0.03958145,-0.034975998,0.012188442,0.034180477,0.08027608,0.054162793,0.008672868,0.0004090718,0.045641724,-0.08321055,0.06945066,-0.025555477,0.04913908,0.023995027,0.039337408,0.05684369,-0.037072223,-0.08082126,0.0037710548,-0.021604443,-0.030565917,-0.017480329,-0.0013353815,0.00031654965,-0.026311696,-0.018386217,-0.005738344,0.013007703,0.013108951,-0.03633018,-0.01216767,-0.03478398,-0.043010827,0.025901638,-0.071198285,0.06262078,-0.028911855,0.0048450534,-0.06254387,0.0123713175,0.03189466,0.0032777963,-0.053476583,0.043861702,-0.04971842,0.0954136,-0.01619951,-0.104691885,-0.033930507,0.073436104,0.047611076,-0.044860136,-0.011819751,0.04420229,0.047014695,0.014444165,0.015539535,-0.07366248,-0.036802974,-0.02780672,-0.033686087,0.015813343,0.050194077,0.09598969,0.0352026,-0.0038805811,-0.0061821905,-0.0036313585,-0.03196938,0.04191302,0.012933675,0.03112432,-0.0037546223,0.029256295,0.014490848,0.107754,0.028194593,-0.0012586424,0.011840968,0.028179325,-0.009693238,0.07618214,-0.069953956,-0.07846461,-0.08271849,-0.017003255,0.039706647,0.018649843,-0.052232575,-0.009116759,0.033564366,-0.107998714,0.035795297,-0.013876912,-0.041389864,0.073999956,-0.01894287,-0.01436878,0.016492285,-0.031335995,0.013279601,0.035978306,-0.038493637,0.08319162,-0.08998941,-0.055871747,-0.0896214,1.5321187e-33,0.051137473,0.018148696,-0.026433473,0.054371934,0.041829947,0.01968344,-0.041592684,-0.007744313,-0.009943836,-0.03471186,-0.10695272,-0.06508136,0.040403746,-0.04036341,-0.054286372,-0.10398534,-0.041680366,-0.0016843957,0.013738864,-0.018459704,0.0005833903,0.020424569,-0.024435578,-0.013687747,-0.03674855,0.004863585,0.002001442,0.044435788,-0.0105148805,-0.002030264,-0.020970961,-0.030148344,-0.090091474,0.010398459,-0.028366355,0.031402823,-0.05389415,-0.045419533,-0.025072867,0.08656175,0.047901843,-0.0006457456,-0.055702828,-0.016192764,0.084557585,-0.00047572772,-0.024307307,0.1256435,0.051459845,-0.008105927,0.08787669,0.06854349,0.06880757,0.04049989,-0.0870983,0.054686986,-0.06690642,-0.027954338,0.0067755883,0.031072097,0.090805836,0.068267964,0.041171882,-0.021108309,-0.11268785,0.097555384,-0.023607243,-0.010572076,-0.11226336,0.015081028,0.012709512,-0.050992735,0.085359156,0.07191458,0.08341014,0.04187596,-0.016450558,0.031743184,0.020210572,0.0044145896,-0.07330806,-0.021694724,0.070099644,-0.025401672,-0.09323836,-0.04054843,-0.0063889762,-0.04097355,0.030633813,0.05752277,0.026338996,-0.11076977,-0.0020041626,0.03807946,0.004474312,-3.086479e-33,0.05449995,-0.10172713,0.0314347,-0.11188553,-0.05773271,0.029672286,0.004766306,-0.06533442,-0.023256255,0.0991232,0.11694987,0.05995225,-0.015602799,-0.11505069,0.035287138,-0.029828824,0.0592215,0.085851766,0.05327738,0.020237258,0.016881974,0.036709286,0.023051415,0.02528579,0.07587766,0.002757976,0.026430462,0.03883976,0.08537863,0.010349212,0.0055632545,-0.014440663,-0.030775107,-0.010026833,-0.039194368,0.1090998,-0.06853368,-0.0851922,0.01070182,0.008528762,-0.0067907395,-0.05754177,-0.008916064,0.045766592,0.076378725,0.029507134,-0.07753156,0.01808767,0.015710719,-0.09983986,0.04241946,0.041956216,0.04891146,0.007682092,0.054821383,0.085153356,-0.07021157,-0.004103538,0.03841705,-0.06543473,-0.006286795,-0.024691334,0.03125219,0.054570798,0.061124235,-0.003113726,-0.050889645,0.09357759,-0.0128845675,0.06472665,0.039168846,0.05232364,-0.031011479,0.036992557,-0.029103726,-0.011892394,0.059970137,-0.07102743,-0.040845443,-0.09828331,-0.076305196,-0.02901014,0.03403569,-0.013166713,-0.07210506,-0.01887635,0.04882033,0.065572836,0.010778912,0.04155856,-0.0056398823,0.015838778,0.008661037,0.122613415,0.09457761,-4.0210832e-08,0.005444706,0.0041068876,0.05874371,-0.052472297,-0.012491665,-0.0014118503,0.017854027,0.008174456,0.039628334,-0.10604847,-0.0823285,0.0056011053,0.091012724,0.020943914,-0.02550091,0.0028933873,-0.037711117,-0.006151019,0.031708203,-0.040049434,-0.06318058,-0.06035779,0.04629368,-0.021254798,-0.00036098293,-0.048387017,-0.005607451,0.0050600474,-0.040546667,0.011814372,0.02024669,0.015397869,0.03149562,-0.0068868906,0.053501535,0.060288932,-0.03419408,-0.07325694,-0.0769528,-0.032188952,-0.06847833,0.02455528,0.0056745443,0.04497448,0.06998328,-0.069120206,-0.008674179,0.01952434,0.00846182,-0.0141138,0.043685663,0.0117637,0.0009981996,-0.025691042,-0.057017814,-0.07643136,-0.07740241,0.014962346,0.029925756,-0.0065407804,0.011478832,0.022526193,0.087687664,-0.011491288 +5.4.99.49,The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.,384,0.99999994,-0.028125642,-0.04765067,-0.10901773,-0.061352275,-0.01958478,0.06920679,-0.0838687,-0.009843596,0.035250228,0.010256138,0.09736696,-0.066457674,-0.08416519,-0.07004133,-0.02108563,0.016923402,-0.01347226,0.07103029,0.0068359254,-0.06775528,0.02414955,0.040533744,0.0011965061,-0.019485077,0.022740921,0.04268708,0.00077877525,-0.047655955,0.02931077,-0.0886246,-0.052964084,0.04487236,0.0041191075,-0.041866295,0.022729643,0.028021878,-0.07223683,-0.022585766,0.119549245,0.025228942,0.0856038,-0.0050272243,0.017239256,-0.03266246,-0.07109137,-0.010696521,-0.10826765,0.08526546,0.060974576,-0.026395239,-0.020448893,-0.07598223,-0.056043264,0.0021037864,-0.008538201,-0.046717312,0.066027224,-0.007276416,-0.039166454,0.09955572,0.049682636,-0.009869272,0.036701407,-0.0048310114,-0.040419124,-0.0294221,-0.026014734,-0.00093364576,0.04618759,-0.05853553,-0.059070375,-0.08001285,-0.05362715,-0.021157185,-0.09287604,0.06628996,-0.030423028,0.04060342,-0.022197096,-0.049475003,0.028028836,0.021141777,0.0997711,0.092285655,0.025797287,-0.0015625375,0.02892743,0.011325741,-0.012275817,0.045208413,0.108009174,0.01879824,0.011814708,-0.010473799,-0.09612065,0.03210484,0.024011264,0.054751903,-0.018646408,-0.09756188,0.046153508,-0.025380425,-0.04511115,-0.11036494,-0.09742311,0.028001642,-0.058542207,-0.11116971,0.09252175,-0.022874247,-0.017167741,0.006845886,0.0051644277,-0.003479376,-0.043096714,0.02312455,0.039932646,-0.08476274,-0.0025663688,0.009652002,0.011099766,-0.06620342,0.07254263,0.005796287,0.0018475963,0.0068815155,-0.029394522,1.3156467e-33,0.069766924,0.07884554,0.032955233,-0.0056365356,-0.04553893,-0.02190014,-0.024937933,0.056042988,-0.09002541,-0.060892034,-0.074018165,0.019988814,-0.015086695,-0.05007829,0.014762808,0.07579661,-0.027027475,-0.010769896,0.07433151,0.002367783,0.0024897011,0.00041281336,-0.08256313,-0.01929606,0.05089582,0.07798089,-0.015045972,-0.060665753,0.011752737,-0.016136052,0.0707775,-0.1314718,-0.03853803,0.06791335,0.016827172,-0.03985221,0.03908157,-0.053174213,-0.14554496,0.047453456,-0.04474498,0.0031969731,0.011433915,0.021611163,0.009982988,-0.05475529,-0.0577662,0.017113004,0.10872876,0.019341962,-0.04771019,0.013033516,0.11590232,0.020700574,-0.047717195,0.057283856,0.016850527,0.020943448,0.032473926,0.040386137,0.009642693,0.053488206,-0.03673557,-0.029602429,-0.015663033,0.07531428,-0.134474,-0.026130317,0.03489625,0.13369761,-0.055245332,-0.03407845,0.04336544,-0.021740736,0.08164666,0.0077924775,-0.022441905,0.009461368,-0.025037259,0.004409492,0.03366897,-0.05477428,0.08448504,-0.010739292,-0.06581862,-0.054843526,-0.03751074,0.03159427,-0.040045764,0.026945809,0.0703332,0.044052552,-0.09845011,0.013641808,-0.010100313,-2.1302233e-33,0.07447331,-0.038765483,-0.0024704633,-0.04127793,-0.02442255,0.11024999,-0.08038103,-0.04681911,0.0120192645,0.009095174,0.040858764,-0.0012608825,0.05463621,-0.013642645,0.03011486,0.0069751525,0.04707114,0.085355826,-0.04630045,-0.06746535,-0.023740277,0.051478785,-0.017179841,0.00034822663,-0.04280049,0.020769404,0.07311974,-0.020019973,-0.017564515,0.071331464,0.060347673,-0.0071614375,-0.025120921,0.021683505,-0.02646942,0.019077642,0.0042237253,0.0258566,-0.0013353131,0.07079857,-0.058714893,0.0015141557,0.03467188,0.03056125,0.04103679,-0.039301723,-0.10454465,0.08714389,-0.022859778,-0.016717143,0.10221863,0.015811445,-0.025856748,0.04011566,0.037269685,0.024171138,-0.0054010227,-0.052737974,0.025577428,-0.030444415,0.0034624883,-0.053421937,-0.05615418,-0.02324467,0.0029608589,0.03307744,0.008444706,0.034501426,0.016124956,0.042908456,-0.0060736276,0.09553135,0.011378622,0.038576454,-0.030510673,0.061078288,0.00876644,-0.11240766,0.034225125,-0.010657087,-0.02720585,0.0074372957,0.052258495,-0.103957795,-0.01046786,-0.00766166,-0.051513445,0.043721054,0.027017925,-0.012596824,-0.022424797,0.00741993,-0.12487778,0.028899707,0.036842074,-2.267076e-08,0.09560193,-0.025190018,0.017378435,-0.010021335,0.027207179,-0.017720254,0.03944996,0.010428409,0.048819385,-0.004297826,0.005132326,0.039051503,0.02473401,0.043295898,0.11906318,-0.015601378,0.086791255,-0.026942886,-0.019448023,0.046372503,-0.04075154,-0.00735825,-0.050544184,-0.013397953,-0.018444607,-0.03994955,0.046916295,0.00783603,0.042913962,0.026221158,0.029201074,0.013213506,0.0032177414,-0.027119132,-0.0441775,0.0452675,-0.022942748,-0.0042378013,-0.029141178,0.041828666,0.0065695397,-0.08602149,-0.06552638,0.036086008,0.010148476,0.020680543,0.05240609,-0.04627647,0.045005284,-0.020060651,-0.03701626,-0.0054204445,0.007986874,0.030550111,-0.093719006,-0.0150388675,0.03820254,-0.03498503,-0.017933842,-0.09246897,-0.043891504,-0.02236235,0.19948964,0.074489914 +5.4.99.50,The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.,384,0.99999994,-0.028125642,-0.04765067,-0.10901773,-0.061352275,-0.01958478,0.06920679,-0.0838687,-0.009843596,0.035250228,0.010256138,0.09736696,-0.066457674,-0.08416519,-0.07004133,-0.02108563,0.016923402,-0.01347226,0.07103029,0.0068359254,-0.06775528,0.02414955,0.040533744,0.0011965061,-0.019485077,0.022740921,0.04268708,0.00077877525,-0.047655955,0.02931077,-0.0886246,-0.052964084,0.04487236,0.0041191075,-0.041866295,0.022729643,0.028021878,-0.07223683,-0.022585766,0.119549245,0.025228942,0.0856038,-0.0050272243,0.017239256,-0.03266246,-0.07109137,-0.010696521,-0.10826765,0.08526546,0.060974576,-0.026395239,-0.020448893,-0.07598223,-0.056043264,0.0021037864,-0.008538201,-0.046717312,0.066027224,-0.007276416,-0.039166454,0.09955572,0.049682636,-0.009869272,0.036701407,-0.0048310114,-0.040419124,-0.0294221,-0.026014734,-0.00093364576,0.04618759,-0.05853553,-0.059070375,-0.08001285,-0.05362715,-0.021157185,-0.09287604,0.06628996,-0.030423028,0.04060342,-0.022197096,-0.049475003,0.028028836,0.021141777,0.0997711,0.092285655,0.025797287,-0.0015625375,0.02892743,0.011325741,-0.012275817,0.045208413,0.108009174,0.01879824,0.011814708,-0.010473799,-0.09612065,0.03210484,0.024011264,0.054751903,-0.018646408,-0.09756188,0.046153508,-0.025380425,-0.04511115,-0.11036494,-0.09742311,0.028001642,-0.058542207,-0.11116971,0.09252175,-0.022874247,-0.017167741,0.006845886,0.0051644277,-0.003479376,-0.043096714,0.02312455,0.039932646,-0.08476274,-0.0025663688,0.009652002,0.011099766,-0.06620342,0.07254263,0.005796287,0.0018475963,0.0068815155,-0.029394522,1.3156467e-33,0.069766924,0.07884554,0.032955233,-0.0056365356,-0.04553893,-0.02190014,-0.024937933,0.056042988,-0.09002541,-0.060892034,-0.074018165,0.019988814,-0.015086695,-0.05007829,0.014762808,0.07579661,-0.027027475,-0.010769896,0.07433151,0.002367783,0.0024897011,0.00041281336,-0.08256313,-0.01929606,0.05089582,0.07798089,-0.015045972,-0.060665753,0.011752737,-0.016136052,0.0707775,-0.1314718,-0.03853803,0.06791335,0.016827172,-0.03985221,0.03908157,-0.053174213,-0.14554496,0.047453456,-0.04474498,0.0031969731,0.011433915,0.021611163,0.009982988,-0.05475529,-0.0577662,0.017113004,0.10872876,0.019341962,-0.04771019,0.013033516,0.11590232,0.020700574,-0.047717195,0.057283856,0.016850527,0.020943448,0.032473926,0.040386137,0.009642693,0.053488206,-0.03673557,-0.029602429,-0.015663033,0.07531428,-0.134474,-0.026130317,0.03489625,0.13369761,-0.055245332,-0.03407845,0.04336544,-0.021740736,0.08164666,0.0077924775,-0.022441905,0.009461368,-0.025037259,0.004409492,0.03366897,-0.05477428,0.08448504,-0.010739292,-0.06581862,-0.054843526,-0.03751074,0.03159427,-0.040045764,0.026945809,0.0703332,0.044052552,-0.09845011,0.013641808,-0.010100313,-2.1302233e-33,0.07447331,-0.038765483,-0.0024704633,-0.04127793,-0.02442255,0.11024999,-0.08038103,-0.04681911,0.0120192645,0.009095174,0.040858764,-0.0012608825,0.05463621,-0.013642645,0.03011486,0.0069751525,0.04707114,0.085355826,-0.04630045,-0.06746535,-0.023740277,0.051478785,-0.017179841,0.00034822663,-0.04280049,0.020769404,0.07311974,-0.020019973,-0.017564515,0.071331464,0.060347673,-0.0071614375,-0.025120921,0.021683505,-0.02646942,0.019077642,0.0042237253,0.0258566,-0.0013353131,0.07079857,-0.058714893,0.0015141557,0.03467188,0.03056125,0.04103679,-0.039301723,-0.10454465,0.08714389,-0.022859778,-0.016717143,0.10221863,0.015811445,-0.025856748,0.04011566,0.037269685,0.024171138,-0.0054010227,-0.052737974,0.025577428,-0.030444415,0.0034624883,-0.053421937,-0.05615418,-0.02324467,0.0029608589,0.03307744,0.008444706,0.034501426,0.016124956,0.042908456,-0.0060736276,0.09553135,0.011378622,0.038576454,-0.030510673,0.061078288,0.00876644,-0.11240766,0.034225125,-0.010657087,-0.02720585,0.0074372957,0.052258495,-0.103957795,-0.01046786,-0.00766166,-0.051513445,0.043721054,0.027017925,-0.012596824,-0.022424797,0.00741993,-0.12487778,0.028899707,0.036842074,-2.267076e-08,0.09560193,-0.025190018,0.017378435,-0.010021335,0.027207179,-0.017720254,0.03944996,0.010428409,0.048819385,-0.004297826,0.005132326,0.039051503,0.02473401,0.043295898,0.11906318,-0.015601378,0.086791255,-0.026942886,-0.019448023,0.046372503,-0.04075154,-0.00735825,-0.050544184,-0.013397953,-0.018444607,-0.03994955,0.046916295,0.00783603,0.042913962,0.026221158,0.029201074,0.013213506,0.0032177414,-0.027119132,-0.0441775,0.0452675,-0.022942748,-0.0042378013,-0.029141178,0.041828666,0.0065695397,-0.08602149,-0.06552638,0.036086008,0.010148476,0.020680543,0.05240609,-0.04627647,0.045005284,-0.020060651,-0.03701626,-0.0054204445,0.007986874,0.030550111,-0.093719006,-0.0150388675,0.03820254,-0.03498503,-0.017933842,-0.09246897,-0.043891504,-0.02236235,0.19948964,0.074489914 +5.4.99.51, The enzyme from Stevia rebaudiana also gives traces of other triterpenoids.,384,1.0,0.021731194,-0.06376047,-0.12740125,-0.02073676,-0.04967541,0.0701816,-0.11440718,0.021532094,0.017287413,-0.020760484,0.09621907,-0.021719927,-0.03357017,-0.08125065,-0.0135914665,-0.0033490912,0.021227064,0.025927138,0.050789528,-0.08100933,0.063385956,-0.015196634,0.012623737,-0.0479099,0.01090868,0.09447398,0.0065219053,0.019299885,0.04259221,-0.07122647,0.011862068,0.021644253,-0.036500692,-0.092806645,0.021450266,0.06298997,-0.027431343,-0.04803988,0.09643911,0.046612427,0.032505255,-0.011954656,0.001498041,0.03071211,0.013086721,-0.07350159,-0.04996082,0.077143915,0.04806498,-0.010312005,0.044355385,-0.094692245,-0.028862612,0.03658354,0.028353631,0.00012267852,0.05899887,-0.018678471,0.0016880187,0.08810905,0.024555327,-0.030389862,0.042198967,-0.053343095,-0.049456,-0.0054691327,-0.042359713,-0.018513124,0.037748847,-0.059791777,-0.02249424,-0.01009304,-0.08939263,0.058353167,-0.119915634,0.030907743,-0.017943433,0.014028124,-0.03903013,-0.039933816,0.022051556,-0.013330295,0.042644426,0.09995612,0.11452908,0.0081664035,-0.01835121,-0.023730673,0.025124544,0.054557957,0.065728106,-0.012859586,0.07590602,0.013034619,-0.063203506,0.024433162,-0.0046155755,0.03559549,-0.03423999,-0.070730336,0.025979849,-0.028924793,-0.09176437,-0.0442655,-0.07394477,0.09274646,-0.037497357,-0.010262408,0.027554296,-0.028863346,-0.038873024,-0.012135347,0.07862441,-0.0134768495,-0.027139235,0.0447614,0.05014903,-0.029058931,-0.04794762,-0.02594432,0.0027045524,0.0027740286,0.07578851,-0.02400293,0.06132467,-0.0019049274,-0.029921696,8.57375e-34,0.052524276,0.11719412,0.008225259,0.014637983,-0.039946843,-0.017630681,-0.04028225,0.10458303,0.0005399995,-0.08479934,-0.08099049,0.024387851,-0.018503498,-0.02705793,0.00028908678,0.026750358,0.033033725,0.014628275,0.045619547,-0.043852314,-0.08276,-0.0147590265,-0.017896581,-0.082181565,-0.018764956,0.03602115,0.0122840395,-0.00526637,0.037329387,-0.019629195,0.007990249,-0.07578586,-0.020207625,0.015753381,0.088229045,0.015864218,0.031550944,-0.03800847,-0.142003,0.06647856,0.021799292,0.011984899,-0.029112851,-0.0004503035,0.03880888,-0.06690164,-0.08111423,-0.013335056,0.094835795,-0.021609623,0.01403159,0.047359467,0.018297927,0.07287791,-0.116013594,0.0006688161,-0.0037557967,0.03860135,0.0173805,0.036935326,-0.014324567,0.09047507,-0.044331104,0.007534673,-0.086201,0.06880233,-0.09464878,-0.06865529,-0.039382327,0.10658459,-0.027663928,0.005772555,0.04701423,-0.031077383,0.075147964,1.758076e-06,-0.013555331,0.027727712,0.0358295,-0.054806616,-0.0042565055,-0.09940561,0.04812356,-0.026385114,-0.06036183,-0.015498979,-0.023471946,-0.06001721,-0.0029472425,0.012530051,0.06883774,0.02680606,-0.061526418,0.042477395,-0.03009677,-1.5938664e-33,-0.020444231,-0.07682322,0.043986723,-0.083098054,-0.015939612,0.10388527,-0.063329406,-0.024729379,-0.0077224006,-0.023829076,-0.0045151087,-0.034046337,0.0036822478,-0.04687692,0.04643045,0.04434984,-0.026924895,0.09988942,-0.031744435,-0.085493244,-0.040399674,0.033264056,0.006874913,0.03160648,-0.026099253,0.062319327,0.088511206,-0.03227971,-0.002230293,0.060523484,0.05789113,-0.06563061,-0.032617453,0.021490771,-0.043815933,0.060788188,-0.008560576,0.010574039,0.0015030041,0.0591878,-0.059582096,0.006605737,0.0062595736,0.01240389,0.02603656,-0.012054583,-0.126015,0.050222848,-0.01080568,-0.015108802,0.13730763,-0.0123014,-0.044263586,0.012602343,0.050289612,0.03240673,-0.052814495,-0.04052177,0.066703685,-0.017030373,-0.01780307,-0.019822307,-0.07323652,0.019007511,0.09125755,0.012515081,0.06664315,0.030805035,-0.035649367,0.033511423,0.008425702,0.06379951,-0.00911585,0.05004122,0.0114049055,0.049326707,-0.059197385,-0.1276307,-0.03730874,0.004503093,-0.08959251,-0.031027112,0.06268721,-0.052257366,-0.032310124,-0.026267549,-0.03767771,0.037440117,0.041278012,0.036722314,-0.005014967,0.015910206,-0.08884096,0.020447826,0.097273424,-2.0091967e-08,0.0855163,-0.023989037,0.0053525846,-0.017744109,0.026746744,-0.020198679,0.02878063,0.039739266,0.055319607,-0.0016715016,-0.025301032,0.07660448,0.0051544467,0.01604271,0.08158703,0.022252413,0.05003134,-0.017536165,-0.012880659,0.028949492,-0.005193814,0.016729278,0.02784813,-0.021591784,-0.03696453,-0.1122594,0.040553436,0.061196316,0.03465206,0.0026740597,0.060786728,-0.035071693,0.054598335,-0.039963964,-0.055813156,0.06982004,0.047245234,-0.0234422,-0.035877272,0.09765781,-0.03457224,-0.07288473,-0.08839229,0.052757736,0.020278689,-0.021432687,0.04386009,-0.006369092,0.01734473,-0.03283965,-0.036275882,0.014265361,0.0025005376,-0.03989463,-0.09117382,-0.032870863,-0.05268167,-0.0052219178,0.0038656997,-0.08310382,0.012602203,-0.0040895995,0.18518308,0.07521356 +5.4.99.52,"The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin. See EC 5.4.99.54, beta-seco-amyrin synthase.",384,1.0,-0.08753134,-0.117895,-0.11399526,0.025359752,0.022129348,0.0067749075,-0.031667568,-0.025185173,0.10468535,-0.012124964,0.08264924,-0.029345894,-0.12706488,-0.034846354,-0.013994964,0.019661022,-0.07964699,0.06188707,-0.09726188,-0.05724822,-0.009593725,-0.02801248,-0.020939196,0.080998875,0.030710252,-0.07766634,-0.019981008,-0.008597036,-0.032661248,-0.047417283,0.00854643,0.011601621,0.040152628,0.026531171,-0.017970009,0.059827976,-0.040989283,-0.16527624,0.07333821,-0.011652518,0.06297177,-0.058145046,-0.03534077,-0.015413039,-0.046612732,-0.038318865,-0.07785173,0.038161512,0.090676464,-0.046219528,-0.04597236,-0.062328503,-0.083936915,-0.044857692,-0.001079072,0.048944347,0.013547253,-0.029784463,-0.015016808,0.101883724,-0.014373573,0.02837418,-0.014027728,0.02963424,0.020423718,0.019283274,-0.037360422,-0.046798762,0.032845233,-0.030043459,-0.025986617,-0.06660493,0.011910539,0.0065700784,-0.023643734,0.02911473,-0.007618184,0.040378615,0.029118923,-0.022603624,0.04786891,-0.031502675,0.02232966,0.0354251,0.0229243,-0.0142542785,0.036351617,0.049770612,0.057223026,0.054988004,0.09488639,0.05295175,0.0024337168,-0.06956788,0.03863899,0.08208032,-0.01539193,-0.05517363,0.023665179,-0.04111903,-0.010788287,0.07874283,-0.031953283,-0.10819703,0.032116577,0.049651,-0.0047573787,0.035108216,0.0367867,0.028817587,-0.011912045,-0.016643623,0.00047641306,0.06914318,0.04038677,0.03978356,-0.025347406,0.014163756,-0.019209968,0.0055506085,-0.004043009,-0.018873539,0.004662392,0.07173323,-0.07757077,0.0111922845,-0.109567225,3.7346902e-34,0.057738367,0.088480875,-0.019817557,-0.04685949,-0.024455523,-0.00558053,-0.07238555,0.02749571,-0.06748309,-0.029096397,-0.083645135,-0.064633146,-0.026724642,0.018227851,0.059378825,-0.0499827,-0.023200268,0.008791899,0.09823367,0.036898024,-0.031392235,0.006859793,-0.076048955,-0.011129741,0.011561678,0.037882566,-0.020323437,0.08345141,-0.02607036,-0.03157171,0.028878253,-0.04882067,-0.025530899,0.030342825,0.07969474,0.0018498277,-0.022274233,0.008481155,-0.044048272,0.058855213,0.047180243,0.05494148,0.04081375,0.023132166,0.07055961,-0.009653557,-0.033870123,0.020450663,0.08167806,-0.007006198,-0.054537423,0.039505426,0.09713999,-0.071444206,0.021636998,0.0016030793,-0.004559197,0.056475054,0.016987456,0.0568157,-0.083821446,0.052708596,-0.030955188,-0.00422056,-0.057443727,0.1053216,-0.0777556,-0.051618367,-0.025342178,0.04336813,0.016248558,-0.02792199,0.022874638,-0.023921562,0.034776017,-0.017694974,-0.013647955,-0.019327682,-0.028510178,-0.018636404,-0.060323685,0.046164595,0.015756324,0.031001765,-0.03394852,0.005212368,0.007396457,0.05980403,-0.027565472,0.038772143,0.10700582,-0.037844244,-0.015552593,-0.008332946,0.016747748,-1.3339358e-33,0.032550987,-0.109882005,-0.01700027,-0.10885339,-0.059382398,0.06721478,0.0025518385,-0.0874833,0.03577771,0.047229428,0.06220026,0.0131676085,0.027425699,-0.11188664,-0.03650322,-0.002816306,0.01963211,0.06953148,0.03951145,0.032551076,-0.011305515,0.080571964,0.10878343,0.007908409,0.08622249,0.010348171,0.052588943,0.09391372,0.006505133,-0.016941642,0.0035750498,-0.08121453,0.0070878426,-0.05649266,-0.08245301,0.012527775,-0.017484229,-0.013343364,0.0145655805,0.014225529,0.0030682296,0.015287455,0.02380863,0.08795626,0.05636225,0.022331685,0.0041587204,-0.0010488057,-0.07237057,0.041540127,0.023649685,-0.02773612,-0.05307173,0.037120894,-0.029073808,-0.011161676,0.047000434,0.07308542,-0.04383792,-0.056822505,-0.0162569,-0.058056552,0.016987022,0.024528207,0.04750698,0.05867138,0.04176326,0.07124104,-0.0009944107,0.008164502,0.121891394,0.029574584,0.0031524727,0.060337782,-0.003922945,-0.019648185,-0.04175863,-0.058908347,-0.0034414798,-0.03184371,-0.023655547,0.09222606,-0.09021134,-0.012967884,-0.045303408,-0.02819348,0.08110601,0.12992944,-0.014316453,0.056312144,0.018513627,0.032884277,-0.04973033,0.0017079095,0.09321672,-3.1106705e-08,0.06223931,-0.030749459,0.039176825,-0.0923155,0.093152605,0.0021504145,0.01633684,-0.011122672,-0.002035672,0.025103485,-0.08484893,0.09425494,-0.016271617,-0.004808069,0.02761148,-0.08636896,-0.025619676,0.068070784,-0.007123814,-0.04209818,0.025755532,0.06790289,-0.08267157,-0.0092355395,-0.01617241,-0.06903924,-0.0100021465,0.0077070263,-0.04343303,0.009631228,0.025023267,-0.015263197,0.0034254512,-0.08509623,-0.01550703,0.045196436,0.0006950583,-0.056868434,0.0048570256,0.006736913,-0.097345084,-0.10866224,-0.008117671,0.0019056096,-0.013280577,-0.009612639,0.051855326,-0.0488407,0.11100313,0.06788665,0.058541205,-0.06360778,0.0007529546,-0.113370284,-0.050650273,-0.04744796,-0.014612918,-0.0619441,0.017634146,0.023426255,0.029058421,-0.037740283,0.13659085,-0.040249396 +5.4.99.53,"Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization.",384,1.0000001,-0.017689347,-0.05708136,-0.04194458,-0.051771518,0.006759535,-0.012071135,0.011912459,0.08108002,0.020985572,-0.035144057,0.06198492,0.0037743386,-0.08531297,-0.068009116,0.014270985,9.422374e-05,-0.027169159,0.04130403,0.06741405,0.032670032,0.010104758,-0.04876999,0.014488502,0.023854962,0.097722635,0.11266587,0.025925284,0.011799863,0.02549509,-0.043812506,0.047901977,0.0722095,-0.030552493,0.041458994,-0.0017011064,0.049815644,-0.057528242,0.004589364,0.058052633,-0.027491668,0.016203186,0.011419351,0.05984903,-0.010847308,-0.037437603,0.03735029,-0.044610072,0.029093739,-0.005281297,-0.047690846,0.11493601,-0.10575042,-0.024249513,0.06552261,0.050136786,-0.006959461,0.037992604,0.051099464,-0.032871462,0.065477796,0.033705004,0.011251622,0.02288974,-0.035524685,-0.046127737,-0.026920903,0.0036182576,-0.02863988,-0.027912127,0.0025977069,0.020881314,-0.0052684597,-0.065951005,-0.0024668942,-0.04155286,0.014591569,-0.039415933,0.015960267,-0.013397404,-0.023021929,0.06947646,0.08668125,0.06471657,0.057613146,0.06875915,0.005017723,0.018051803,-0.029261926,0.019051807,-0.00070288545,0.058310844,0.06269362,-0.05039614,0.06084833,-0.08118235,0.08732108,0.06569449,-0.03626386,-0.04900908,0.03241062,0.06620554,-0.00408745,-0.050922245,-0.039144095,-0.022181725,0.04765302,-0.04334339,-0.07229373,-0.037877634,-0.0033401432,-0.056601677,-0.030858679,0.0097692665,-0.045064494,-0.044664513,0.02755021,0.02734609,0.007803235,0.041451465,-0.024400823,0.017040135,0.057427753,-0.02439706,0.05748568,-0.07531464,-0.031023158,0.023439588,9.14867e-34,-0.015569042,0.040031567,-0.011087517,0.077785775,-0.10934231,-0.036324054,-0.070693664,-0.048719663,-0.046417005,-0.078173205,-0.09507381,-0.04548237,0.037943423,0.019640604,-0.022011751,-0.05373779,0.011362929,0.061294053,0.084625676,-0.086914405,-0.02608905,-0.010521329,-0.05819568,-0.034822542,-0.007906105,0.0434826,0.043559004,-0.08839452,0.039212264,-0.016644306,0.005307112,-0.07287324,0.0033212334,0.08488458,0.012277134,-0.0039080065,-0.019025873,-0.019696198,-0.055610713,0.0173068,-0.031646527,-0.045991518,-0.043520037,-0.04006072,0.08452787,-0.043097578,0.010880007,0.06432921,0.049104344,-0.03342436,0.06425087,0.010981593,0.023087217,0.10628538,-0.09151077,0.115492865,0.035079744,-0.009056061,0.016085826,-0.05640586,0.02451169,0.051612306,-0.021600656,-0.09027437,-0.018062131,0.09064548,-0.13459045,-0.06265668,-0.039865352,0.090125695,-0.0865111,-0.048659932,0.119115606,0.05834893,0.1001775,0.09177447,0.009172482,0.04702266,0.03875496,-0.016596228,-0.13571878,0.031020775,0.07744433,0.013358395,-0.064594805,-0.036779404,-0.032125622,-0.012189657,-0.01362677,0.06579614,0.08104765,-0.021217754,-0.02120442,0.005264314,-0.043682735,-1.4707185e-33,0.029836683,-0.042459108,-0.024802111,-0.049471665,0.020238636,0.05392705,-0.08023598,-0.04644113,-0.07101411,0.03211323,0.048070945,-0.053988285,-0.037358627,-0.10253775,0.042681687,-0.0466932,0.018431563,0.10429709,-0.024473801,-0.024952596,0.08091836,0.009797191,0.041332405,-0.021322055,-0.07223501,-0.037742246,0.06674135,-0.033330638,0.08120168,0.03587999,0.0101411445,-0.06464983,-0.040832542,0.034012765,-0.00977786,0.11469673,-0.07218516,-0.020063935,-0.07141827,0.041593928,-0.09045349,-0.006013562,-0.023482373,0.064793855,0.0867854,-0.032499995,-0.030832542,0.061650954,0.07270447,0.033417523,0.031167388,0.008786656,0.013778796,0.0012239664,0.031698428,-0.01299892,-0.020844609,-0.08682518,0.011991733,-0.00088816177,-0.023842692,-0.032680236,0.020941475,0.021668788,0.04608303,-0.021387782,-0.06531234,0.104308,-0.0160858,0.06086757,0.07987586,0.10688812,-0.0031872473,0.010840815,0.08319815,-0.020911517,0.03146249,-0.108839035,0.008036609,-0.036375955,-0.013088737,0.015575966,-0.0024465427,0.01326844,-0.031480525,-0.12567453,0.011153186,0.06512544,0.053113133,-0.01375941,0.021924946,0.016409216,-0.009546001,0.07381266,0.099218346,-3.144308e-08,0.003064113,0.07264429,-0.01164262,-0.018401604,-0.04798971,-0.038589034,0.017703244,0.036718916,0.046832003,-0.094763465,-0.012229536,0.047914606,-0.001296422,-0.011385477,0.06011919,0.019725047,0.0077021923,-0.0047476143,-0.025142968,-0.030846218,0.019096307,-0.044423252,-0.033986356,-0.070561714,-0.024186198,-0.07293027,0.01949709,0.048369516,-0.051889222,0.005059195,0.042134672,0.041858114,-0.03691556,0.0072459243,-0.034978915,0.09453609,-0.061842937,0.023507785,-0.03358921,0.05067824,-0.08366867,-0.006243725,-0.034222748,0.031690184,0.0036059832,0.032594882,0.00414871,-0.013602758,0.0032640721,0.001873949,-0.0060877483,0.012622009,0.009914588,-0.029689435,-0.09883749,0.007550871,-0.063416265,0.02322929,0.0393576,-0.11661486,-0.09305075,-0.023201136,0.093708135,0.09517232 +5.4.99.54,"The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin. See EC 5.4.99.52, alpha-seco-amyrin synthase.",384,0.99999994,-0.08616751,-0.11747081,-0.11846335,0.02043301,0.02323992,0.0018723605,-0.026905386,-0.026942799,0.10264699,-0.011430236,0.084619366,-0.030276017,-0.13158661,-0.032502994,-0.012123588,0.020158306,-0.08617142,0.06100473,-0.099863715,-0.053390417,-0.011353626,-0.031671774,-0.022842726,0.08370028,0.025232404,-0.07371451,-0.016989412,-0.009591652,-0.028237235,-0.047809176,0.011567002,0.0077627706,0.04590855,0.025625382,-0.018328302,0.059929673,-0.043934643,-0.1632211,0.07336194,-0.009371205,0.0649512,-0.058584467,-0.032896727,-0.0151964985,-0.050252303,-0.040203642,-0.082497545,0.03418937,0.0829504,-0.037233498,-0.0406524,-0.05900161,-0.08645626,-0.04651485,-0.0026832214,0.054732725,0.014431983,-0.025728844,-0.021245219,0.10393015,-0.013477963,0.028282793,-0.014733032,0.030187897,0.020120954,0.020734431,-0.03138914,-0.049970616,0.031253386,-0.032436352,-0.02687908,-0.06541572,0.014756755,0.0073874476,-0.02673467,0.033073016,-0.005539513,0.03763312,0.033430584,-0.024037177,0.05158809,-0.033675287,0.018728772,0.043731872,0.023377167,-0.014856521,0.035254396,0.043209925,0.05984876,0.054329142,0.097925715,0.053855147,0.0051689777,-0.06995141,0.041093167,0.08933821,-0.021969544,-0.05334934,0.019964283,-0.04245517,-0.009898672,0.08025357,-0.03659225,-0.10532081,0.026718555,0.046416722,-0.007048801,0.029655814,0.034225293,0.03539476,-0.011553763,-0.021794137,0.0029546828,0.06396167,0.044944726,0.03984915,-0.02079234,0.017639415,-0.01386984,0.0010493475,-0.007078495,-0.015136486,0.011130736,0.07478012,-0.070730776,0.009626943,-0.1016584,4.034863e-34,0.05710847,0.089796685,-0.024173819,-0.049009893,-0.028698253,-0.0030193753,-0.06890227,0.026326008,-0.06901633,-0.031031651,-0.081514284,-0.05998611,-0.02531042,0.012581219,0.056507263,-0.058078036,-0.017701525,0.007248016,0.08961436,0.03968645,-0.024738863,0.010839989,-0.07256892,-0.007107505,0.005930314,0.035484515,-0.02393769,0.078089036,-0.027870165,-0.032589734,0.02612555,-0.04304233,-0.036218796,0.033428192,0.078637734,0.0011905163,-0.023149753,0.011040491,-0.04103295,0.06625766,0.04444128,0.055629205,0.046937212,0.019398864,0.072300084,-0.012506811,-0.03458557,0.024776943,0.08250034,-0.013929545,-0.058457144,0.036126114,0.09406309,-0.07118167,0.023981221,-0.0068842005,-0.004192114,0.06028949,0.020415487,0.058567606,-0.07776324,0.05672007,-0.029895866,-0.0004946603,-0.0628557,0.10368628,-0.073640086,-0.05443057,-0.022059383,0.044989552,0.018999154,-0.031785496,0.02610765,-0.025088856,0.035335094,-0.018193066,-0.013402968,-0.009716154,-0.030277465,-0.018505458,-0.062118966,0.045603283,0.022419905,0.03770453,-0.036206603,0.00054728956,0.0033755898,0.064309776,-0.03126039,0.036581192,0.105224244,-0.037792567,-0.017200379,-0.007148954,0.012087307,-1.3302009e-33,0.031789325,-0.11150035,-0.017296508,-0.105341814,-0.065276444,0.07193255,0.00549149,-0.077364266,0.039404254,0.048696276,0.06610864,0.014583498,0.027228849,-0.111734554,-0.030900463,-0.0037797063,0.02047799,0.07522946,0.03967778,0.030785851,-0.009266704,0.07923812,0.10368868,0.012419805,0.09632192,0.008159696,0.05887137,0.08916907,0.0016510561,-0.022237925,0.0024801525,-0.08552277,0.008191265,-0.05424039,-0.08109577,0.014165611,-0.008260309,-0.014945151,0.00073890114,0.009661287,0.0007610115,0.014746514,0.027750544,0.08922177,0.054380503,0.015288754,-0.00047178188,0.0024506792,-0.071393736,0.050133474,0.023283469,-0.029695714,-0.049292307,0.036753334,-0.033863686,-0.01216254,0.050953638,0.070388764,-0.047200263,-0.052975178,-0.0200472,-0.05481644,0.015533037,0.021124179,0.046112698,0.055274695,0.04120068,0.071680896,-0.0016492758,0.006293023,0.122585595,0.031712472,0.0070394734,0.05971605,-0.00011523604,-0.016809842,-0.03174121,-0.059772734,0.0040166443,-0.035772182,-0.02344449,0.08996925,-0.08474067,-0.006405056,-0.043076918,-0.028044812,0.082325675,0.12331783,-0.017012624,0.055805895,0.017522743,0.029715711,-0.049668625,-0.0027869695,0.09526066,-3.083985e-08,0.061055686,-0.032940287,0.036331847,-0.08982115,0.09925642,0.0033841569,0.01100026,-0.016944597,-0.0005336657,0.020331098,-0.08315938,0.09568902,-0.012881932,-0.0020521297,0.024949363,-0.08746718,-0.021106461,0.06726402,-0.0087458575,-0.04102545,0.024161393,0.06257597,-0.08692656,-0.019053051,-0.011945545,-0.06848594,-0.012000517,0.008779195,-0.04417367,0.008039452,0.022915632,-0.022255497,0.00869826,-0.08310626,-0.010443069,0.048907105,0.0026271373,-0.061902117,-0.0029777463,0.0044636666,-0.10196359,-0.11158338,-0.0045668883,-0.001961518,-0.010299437,-0.009352432,0.04169531,-0.052767027,0.109697714,0.07016751,0.05490106,-0.06346852,0.0049228095,-0.11071831,-0.046181723,-0.05653787,-0.011443274,-0.0667904,0.021690154,0.02527935,0.03250566,-0.034432787,0.13631476,-0.03903129 +5.4.99.55,"The enzyme from tomato (Solanum lycopersicum) gives 48% delta-amyrin, 18% alpha-amyrin, 13% beta-amyrin and traces of three or four other triterpenoid alcohols [1]. See also EC 5.4.99.40, alpha-amyrin synthase and EC 5.4.99.39, beta-amyrin synthase.",384,1.0,-0.032108948,-0.10412948,-0.11863322,-0.0050841947,0.07421803,0.047155004,-0.023899533,-0.019095728,0.063669294,-0.04772665,0.088160396,-0.015694365,-0.12062445,-0.0012593728,-0.052306406,0.034652162,-0.098453976,0.03713456,-0.05525974,-0.03262143,-0.053494997,0.023609037,0.04907371,0.049416933,0.0843073,-0.031319488,0.0016391514,0.0014712714,-0.007029075,-0.05932166,-0.006742169,0.048567407,-0.018581884,-0.022815252,-0.011475744,-0.047659323,-0.052035734,-0.12771027,0.07657344,-0.026491262,0.10834138,-0.015567189,0.02352937,0.005760723,-0.02837051,-0.027231546,-0.11901964,0.040791392,0.04073136,-0.02700248,0.005816059,-0.065319,-0.009215368,-0.060491797,0.04387652,-0.022237992,0.06153442,0.002983598,0.0066271024,0.09214422,0.014883228,0.07133923,-0.011047148,-0.013239153,-0.067768455,-0.009516828,-0.016646665,-0.023136377,0.020142965,0.0013909274,-0.080451585,-0.10829925,-0.0031587826,-0.03447226,-0.054157894,0.032492734,0.0069655343,0.018317176,-0.0034350709,-0.034791883,0.013570914,-0.024228463,0.037218712,0.096692406,0.013005118,-0.037578534,-0.009881948,0.023360403,0.029123586,0.09632167,0.098023035,0.0008160313,-0.062939756,-0.08481846,-0.0077365423,0.08947851,-0.0025167996,-0.04829337,-0.00796648,-0.025742648,-0.018971942,0.020219564,-0.022012934,-0.12853473,-0.01656284,0.055032983,0.05182203,-0.011775744,0.038623597,0.028607307,0.0019343959,-0.02846689,-0.01968421,0.013641737,0.04720848,0.000923118,0.041004166,-0.020829372,0.0022939006,-0.01702099,-0.05876533,0.03039275,0.12258546,0.052001115,-0.028600063,0.018949313,-0.08881283,2.3340919e-33,0.084621936,0.07559738,-0.054595027,-0.007114889,0.006002446,-0.053115398,-0.03281771,0.07644017,-0.0016278521,-0.08035259,-0.15216452,-0.055906102,-0.007605437,0.0016814279,0.04442837,-0.016396377,-0.0018693844,-0.027811706,0.05470387,-0.0010130699,-0.05540786,-0.01718562,-0.0693792,-0.018266235,0.030925076,0.01647865,-0.029884819,0.07866788,0.04047394,-0.03659031,0.026870377,0.0099803535,-0.019177256,0.03800831,0.08791328,0.093415745,0.0025011252,0.016348941,-0.03390232,0.09213064,0.04885851,0.04304395,0.059866715,0.015061401,0.018003123,0.035201214,-0.064569846,0.056510463,0.049978636,0.009450947,-0.015268563,0.0012837929,0.059608765,-0.029805029,-0.029820245,0.047384657,-0.0029183717,0.03477519,0.06392114,0.05007717,-0.068701446,0.047610104,-0.007856298,-0.045952972,-0.035666022,0.10632129,-0.06952421,-0.08631162,-0.033139747,-0.023838574,-0.0035725206,-0.06373119,0.10293919,-0.04458161,0.0723696,0.04887347,-0.022851652,-0.023568684,0.0017503107,-0.015398621,-0.076472074,-0.014687422,0.06439977,-0.037485693,-0.009943859,-0.029777432,-0.030121133,-0.00031717506,-0.0071770144,0.021337138,0.09409867,-0.050062727,0.0076137925,-0.015919596,-0.0533241,-2.2179633e-33,0.002646318,-0.081390575,0.013353278,-0.07271816,-0.014110975,0.018470082,0.011440087,-0.07886238,0.036723457,0.0076221596,0.06319751,-0.040271502,-0.00053840975,-0.060882658,-0.015016154,0.038053043,0.0073047606,0.1269598,0.034733854,0.0041264463,-0.029169353,0.052633394,0.075606525,0.036770556,0.022867847,-0.0018666687,0.046124946,-0.009274244,-0.017002467,-0.036456786,-0.00871805,-0.096080184,0.026764093,-0.034264877,-0.039135672,0.029120278,-0.023121126,-0.03904913,-0.029073857,0.039631363,-0.0027172682,0.017041327,-0.028423268,0.073310606,0.081924245,-0.013350596,-0.03949267,-0.015921356,-0.073679686,0.0066921934,0.10311676,-0.007439935,0.009429916,0.05447593,-0.015189843,0.04609888,0.07647437,0.02848502,-0.011003532,0.025290819,-0.0023383696,-0.01436911,-0.030157417,0.020757893,0.03850811,0.025812736,0.02018812,0.12803933,-0.004598215,-0.0548032,0.06727137,0.023421448,0.04193409,0.10864873,-0.01698406,-0.055345193,-0.012288877,-0.077930786,0.032314956,-0.027624914,-0.040059436,-0.0005346717,-0.088558055,-0.020660233,-0.060395993,-0.078829214,0.060522392,0.04129992,-0.034089368,0.032341175,0.00699648,0.070020825,-0.050244324,0.03516444,0.06925279,-3.3172313e-08,0.05071115,-0.027200814,0.046092995,-0.00086609676,0.06854002,0.03388557,0.031349186,0.036741316,0.011163677,0.023161488,-0.0669857,0.11758172,-0.092900425,-0.019842872,0.005966278,-0.062794715,-5.4454136e-05,0.057831623,-0.030202556,-0.021951338,0.038737055,0.10821274,-0.060548857,-0.080000356,0.005001491,-0.09395792,-0.01977679,0.052370593,-0.010620076,-0.019063277,-0.00029525324,-3.4202636e-05,-0.021922339,-0.07864538,0.018780604,0.06289814,0.022941789,-0.11175948,0.0015262252,0.10949589,-0.09354636,-0.101081096,-0.03636686,-0.021608438,-0.0058653704,-0.037161045,0.0012864348,-0.012128364,0.05805,0.0005151929,0.08418829,0.007896196,0.010362831,-0.06176214,-0.029049326,-0.046989042,0.013190913,-0.014382541,-0.037265666,-0.0078953765,-0.0055790627,0.047038257,0.16867365,0.04705204 +5.4.99.56,"The product from Arabidopsis thaliana is 85% tirucalla-7,24-dien-3beta-ol with trace amounts of other triterpenoids.",384,1.0,0.015521423,-0.06020746,-0.16286416,0.014428374,-0.010392397,0.018192489,0.055087887,0.06650674,0.063355334,0.018724535,0.15059763,-0.07679582,-0.049182683,-0.0414211,-0.008251093,-0.04349823,0.018025938,0.02935778,-0.09848534,-0.070060074,0.057448994,0.045197155,0.046192843,-0.02135974,0.0358138,-0.012727235,-0.05637741,-0.00665198,0.028410506,-0.09972497,-0.07512321,0.09586436,0.042195812,-0.06578826,0.008235537,0.014645638,-0.07320705,-0.10095228,0.062461738,0.034890648,0.0735159,0.0038401857,0.025028752,-0.005607916,-0.08648513,0.016479075,-0.07358492,0.054857835,0.09856488,0.016838552,-0.01912953,-0.015080405,-0.035588417,0.037901692,0.019829487,-0.07621952,0.036523595,-0.05549163,-0.028074063,0.07313464,0.029779388,-0.01615629,0.017212545,-0.02481258,-0.06748513,0.0021794196,-0.04886149,-0.056389444,-0.052199103,-0.034012403,0.018176356,0.010280682,-0.049556985,0.054724965,-0.06314987,0.082828835,0.049042046,0.026612861,-0.07204058,-0.049354266,0.06433778,0.0064058346,0.08460827,0.122443385,0.027172828,-0.007997491,-0.029098745,0.058448914,0.059544764,0.07370552,0.03786109,0.13128534,0.042399924,-0.021705903,-0.026425423,0.0972686,0.064971134,-0.04057315,-0.060395066,0.0005416325,0.03365919,-0.022018135,-0.06930929,-0.054065086,-0.089095086,0.07289558,-0.0432763,-0.056260437,0.014970636,-0.0002338091,-0.0040630563,-0.036999654,-0.03816868,0.00672529,-0.08981178,-0.04865317,0.054575045,-0.055799056,0.039314948,-0.033499777,0.0016588384,0.018186465,0.0712307,-0.03832055,-0.027203312,-0.019138645,-0.061838955,2.1671952e-33,0.03230196,0.04784191,-0.06440886,0.015322342,-0.017936373,-0.025615321,0.0015095309,0.054796167,-0.0034760376,-0.04700944,-0.17497705,-0.009964891,-0.0081807,-0.020082064,-0.010306465,0.017184665,-0.027073542,0.008140132,0.08176642,-0.04580978,-0.043960616,-0.0003913273,-0.0677496,-0.04889499,-0.022381077,0.009376326,0.017916558,0.003908866,0.015796082,-0.035089456,0.010434529,-0.046931483,0.09298011,-0.046704676,0.03332772,-0.065570965,-0.02925074,-0.02189666,-0.072384246,0.11629553,0.019577328,0.05706508,0.07114221,0.030650092,-0.020946933,0.036389127,-0.0091384575,0.008397433,0.117426425,0.04079715,0.016964141,0.062347848,0.055987664,0.00016698272,-0.059562586,-0.018218663,-0.033447888,0.03538115,0.008194903,0.069596246,-0.06169055,0.06156974,-0.0004506769,-0.006564425,-0.06805672,0.11563084,-0.18264194,-0.09675198,-0.019077428,0.06042433,-0.019283678,-0.031638134,0.11044996,-0.0020123932,0.09391297,0.03509097,0.038228825,-0.00849817,0.0068253786,-0.02287133,-0.031570528,0.0021547049,0.034402415,-0.026419409,-0.08266647,0.004283553,-0.012023967,-0.00387179,-0.04715646,0.0033646538,0.065376036,-0.0034635726,-0.058566194,-0.006378996,-0.037391547,-1.7821488e-33,-0.046384096,0.029652527,0.020541871,-0.056407783,-0.010559324,0.041405376,-0.06931786,-0.07562415,0.05002627,0.05758121,0.061584756,0.026666684,0.046637572,-0.015488313,0.01675714,0.016321415,0.055244796,0.09222684,-0.038500395,-0.075321496,-0.046033837,0.006119715,-0.025540683,0.03316637,0.0029431977,0.006338935,0.025591007,-0.026905693,0.02368229,0.0050256494,0.043799475,-0.12878485,-0.0005244215,0.03731712,-0.03879135,0.037868094,0.01651366,-0.055849515,-0.005582745,0.0126565695,-0.026049603,-0.07397851,-0.016238213,0.08001206,0.014989138,-0.026243852,-0.040427644,0.023629807,-0.007702712,0.045235448,0.054099906,0.0068906704,-0.0122526195,0.060422413,0.0064637423,0.030425807,0.029937176,0.032610916,0.009849653,-0.011762763,0.11689326,-0.04211229,-0.020258384,-0.0068715937,0.055504348,0.05742659,0.023469359,-0.0026322135,-0.004432677,0.1063118,0.038832366,0.082961254,-0.06623682,-0.016400414,0.012234901,-0.0023344099,0.027634395,-0.07214063,-0.03536887,0.008764071,-0.020013973,-0.02549646,-0.013196137,-0.09398034,-0.024668619,-0.029699596,0.036116183,0.04920325,0.048766963,0.042308826,-0.017839216,-0.003965684,-0.06307824,0.023444178,0.05473545,-2.8626479e-08,0.015636487,-0.02042258,-0.023128655,0.0044771885,-0.026158266,0.043280046,0.044581197,0.026468422,0.044841215,0.052946698,0.009041381,0.06204835,-0.070464075,-0.022365341,0.08796912,-0.03019623,0.024106551,0.061421756,0.03916826,0.041747835,0.01929333,0.012675213,-0.029151449,-0.077228986,-0.07423303,-0.10620158,0.022739256,0.046096016,-0.001544474,-0.039080676,0.057981778,-0.0384791,0.010565825,-0.055432122,-0.052207023,0.0042704535,0.0007386154,0.0084067,-0.036673993,0.038902313,-0.013298828,0.003815377,-0.090180926,0.059411168,-0.026788838,-0.055704493,-0.0010886765,0.0034766358,0.051493473,-0.020477317,0.01860306,0.015702782,0.0027125645,-0.006288183,-0.021169962,-0.11637772,-0.018790375,0.01605322,-0.054939415,0.05351626,-0.0011939338,-0.013958858,0.12986226,0.061428998 +5.5.1.20,"The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi. The bifunctional enzyme catalyses the oxidation of prosolanapyrone II and the subsequent Diels Alder cycloisomerization of the product prosolanapyrone III to (-)-solanapyrone A (cf. EC 1.1.3.42, prosolanapyrone II oxidase). ",384,0.99999994,-0.06668506,-0.032221235,-0.1183738,0.019871444,0.1036506,-0.010130192,-0.07156797,0.0607779,0.023292057,-0.05264717,0.07981378,0.016712492,-0.0091325,0.008020136,-0.05997686,0.07853675,-0.13356993,0.053126045,0.0004237674,0.009997306,0.02554736,0.017262468,-0.03282198,0.018946862,0.025839033,-0.009910292,0.043852985,0.015423353,-0.009272761,0.006107004,0.033739187,-0.045228742,-0.010127862,-0.041291215,0.01008012,0.038456902,-0.082336806,-0.020777732,0.118032865,0.03891895,0.034952547,0.030977858,-0.080927014,0.008816925,0.008083952,-0.06339558,-0.015108771,0.019963814,0.042089093,-0.030412769,-0.07072456,-0.048511114,-0.066989675,0.05742331,-0.022200515,-0.054188434,0.020391861,0.020403787,0.015702847,0.03111976,-0.0084223,0.035978246,0.017522948,-0.0438998,0.0006198953,-0.058570426,-0.02662888,-0.041128196,-0.03448438,-0.059661236,-0.07783992,-0.05164205,-0.009973481,0.06921213,0.0035139385,-0.023764795,-0.05231551,-0.014946692,-0.09277266,0.032206096,0.04550162,-0.030157745,0.09059223,0.056865226,0.06815568,-0.022238238,-0.020975841,0.02629588,0.07201323,0.006934516,0.06277941,-0.010826916,-0.009835037,0.038079895,-0.022941224,0.065057024,-0.01267654,0.109729365,-0.035342187,0.006050362,0.02315684,-0.057508323,-0.14815073,-0.07419399,0.014560078,0.026824228,0.050980408,0.039079342,0.006646775,0.0010442743,0.030274112,-0.031626344,0.016627455,-0.044866797,-0.03397523,0.096404135,-0.01258381,0.018632168,-0.0032351194,-0.032772467,0.01782056,0.05875714,0.051111825,-0.024596635,0.01587275,0.040901143,-0.051055763,5.8751138e-33,-0.0017710292,0.0364493,-0.026445452,0.016639408,0.020686524,-0.06980609,-0.030968681,-0.020538896,0.025440672,-0.051277325,-0.15777594,-0.05935962,-0.041657995,-0.06677534,-0.004766782,-0.033588238,0.009090187,-0.04974031,0.051387597,0.06598322,0.061881527,-0.071231745,-0.03869935,0.033885643,0.03585027,0.063646674,-0.01110459,0.023636946,0.050631616,-0.018000998,0.0080069,-0.09887656,-0.11636403,0.040072747,0.033238593,-0.024742022,-0.034426518,-0.055836584,-0.08933698,0.035078447,-0.08234511,0.027577838,-0.035696212,-0.022417558,0.07364058,0.019219324,-0.04400261,0.17886318,0.0977613,0.022864813,-0.026411396,-0.0035198194,0.074951395,0.052594837,-0.05849306,-0.009366441,0.011477932,-0.033054166,0.06423018,0.057937052,-0.0070455205,-0.0012259808,-0.010268488,0.023498695,-0.0027407121,0.06013361,-0.059576936,0.02835505,0.025769614,0.022875011,-0.087862894,0.0061314227,0.00080849463,0.050194275,0.00621518,-0.042689413,-0.032779004,-0.0027376236,-0.053344134,-0.014977113,-0.027182167,-0.0723527,0.0038418216,0.02190017,-0.049290605,0.025373202,-0.08635178,-0.04029899,0.0057804454,0.0028805432,0.06430116,-0.0025001275,-0.04087385,0.03213631,-0.015729032,-5.7774376e-33,0.09722459,-0.053295497,0.043154813,-0.08862607,-0.014414842,0.025602633,-0.08788345,-0.006381548,0.014675275,0.01785546,-0.041536346,-0.03527853,0.0012150698,0.00047770631,-0.054128848,0.05638647,0.018686777,0.11673867,-0.006969252,-0.071572505,-0.027345715,0.09123128,-0.04091887,-0.042716954,0.045454048,0.02165901,0.04981349,0.05443397,0.050272584,0.0563209,0.0041925735,0.010020205,0.02521281,-0.015911782,-0.012586132,0.113096,0.010858536,-0.034443405,0.023684636,0.08854535,0.023200193,0.010615636,0.009211459,0.07281201,0.027931504,0.020084532,-0.08025917,-0.0036661057,0.024457669,-0.10369253,0.05155489,0.057731844,-0.014300644,0.005883311,0.034454364,0.02744075,-0.002125962,0.024889508,0.01892256,-0.020729782,0.0057678595,-0.051429857,0.0068731713,0.018911341,0.027862255,0.0131602995,-0.05608056,0.06197961,0.043669708,0.023660656,0.09448676,-0.02988258,-0.034855634,0.08990122,-0.07744297,0.01423008,0.0034993077,0.0025379637,0.006519261,0.035849795,0.048155904,-0.09180007,0.075540625,-0.05188546,-0.08539181,-0.077052005,0.04120629,0.056150164,-0.05844593,-0.01702587,-0.0072298,-0.0039793756,0.0114107495,0.09241711,0.055461373,-4.16842e-08,0.017926944,-0.013572297,0.016059168,-0.06872378,-0.008490401,0.03445653,0.022732338,0.020472327,7.916755e-05,0.019454403,-0.07374029,0.065740734,0.045506094,-0.025869135,0.069235764,0.021643475,-0.002186542,0.10243344,-0.0077813608,0.039642684,0.01624646,-0.053087298,-0.102461554,-0.033938214,0.0059945565,-0.096980385,0.012167866,0.045175735,-0.0069832946,-0.008021408,-0.062860645,0.010683711,0.06440209,-0.08603643,-0.07140161,0.08439238,-0.07912128,-0.066564776,0.04059631,-0.017897328,-0.028612059,-0.09752889,-0.10723331,0.006224153,0.033931322,-0.0013778493,0.030896882,-0.007667827,-0.00038315842,-0.055394027,0.07870483,-0.030118953,0.029365111,-0.013032378,-0.051641505,0.044205774,-0.027072426,0.039689433,-0.044478633,-0.11291364,-0.020884259,0.0972989,0.18444844,-0.015285024 +1.5.8.3,"A flavoprotein (FMN) found in eukaryotes. In the absence of tetrahydrofolate the enzyme produces formaldehyde. cf. EC 1.5.3.1, sarcosine oxidase (formaldehyde-forming), and EC 1.5.3.24, sarcosine oxidase (5,10-methylenetetrahydrofolate-forming).",384,0.99999994,-0.03715679,-0.03089862,-0.15567607,0.07471493,0.12884468,0.015949678,-0.017437475,0.02834969,0.06899233,-0.04523878,0.050790433,-0.031630985,-0.124313205,0.019272583,-0.06927616,0.0054929936,-0.0840885,-0.013423132,-0.04065011,-0.012029863,-0.017482033,0.033166654,0.07488848,-0.0067283157,-0.026345244,-0.0721979,0.025365423,-0.026408134,-0.034722287,-0.027643077,0.060479205,0.032217037,0.045119442,-0.014008235,0.00980674,0.015883943,0.057998445,-0.040829886,-0.003842546,-0.017674953,0.004784735,-0.033611022,0.021240415,-0.063252285,0.0373194,0.011987415,-0.011997022,0.041009784,0.008628252,0.044207055,-0.07262182,-0.04910684,-0.09210513,0.0399386,0.04858261,0.012845669,-0.048495397,-0.052969407,-0.05143714,0.052583605,0.004520747,0.024188468,-0.036108598,-0.03627249,0.036317363,-0.042059146,0.024097553,-0.059076387,0.05132199,0.006923897,-0.026541855,-0.047781426,-0.03745353,0.08323739,-0.041453134,0.09292779,-0.036346227,-0.013494404,0.039832897,0.014154756,0.030434184,0.0019500519,0.044050813,0.072174676,0.0093769645,-0.07171788,-0.042636752,0.027391853,0.029802205,0.06810132,-0.007140429,0.075117856,-0.00959867,-0.02982035,-0.055968482,0.053622786,0.10266668,0.12255085,0.03435791,0.0060214144,-0.024963517,-0.02920069,0.008984536,-0.013051994,-0.054102585,0.02615331,-0.014648873,0.033674616,0.062761076,-0.017140124,-0.007912474,-0.003634554,-0.017717993,-0.12923045,0.030156095,0.03369491,-0.02118425,-0.082144715,-0.0105168745,0.04132652,-0.020117488,0.057421982,0.064378366,0.09629208,0.034589328,0.042278696,-0.13815856,2.3557731e-33,0.07176507,0.069342844,0.012327028,0.019372974,0.0042192345,-0.031634446,-0.0012350973,0.005060092,0.0294732,-0.016834766,-0.11091999,0.008243958,-0.0039004646,-0.021541396,0.04604669,0.003885047,-0.04292212,-0.06604441,0.032005895,0.04288426,0.0210717,-0.00021350701,0.0029279797,0.021001682,0.0132341,0.0075788046,-0.039516088,-0.026805216,0.0060867914,0.02455113,0.010535853,-0.13693461,-0.055399686,-0.0031656574,0.016423862,0.03303217,-0.053041443,-0.021747239,-0.071358494,0.08158434,0.08479257,-0.030941071,-0.014865355,0.0036305506,0.031095322,-0.00073292747,-0.07416634,0.101497136,0.037462298,0.06669662,0.03822843,-0.027896665,0.09438497,0.03824339,-0.045254014,0.047401283,0.0014075933,-0.0022847687,0.04017984,0.022071699,-0.037554003,0.037860252,-0.016306635,0.03449601,-0.027511464,-0.008392628,-0.018463545,-0.017656269,0.021574527,-0.008492711,0.037478387,0.007257433,0.09764713,-0.0009919031,0.04493957,-0.009184133,-0.10715732,-0.0035904038,-0.026114611,-0.0029918035,0.008887872,0.000104735394,-0.032187708,0.0047495784,-0.033110306,0.039454002,-0.021409078,0.02753814,-0.023557095,0.0354553,0.02980699,-0.058351107,0.01201369,-0.049119573,-0.011989774,-1.8231286e-33,0.03618608,-0.07451873,-0.094749615,-0.021934493,-0.030510446,0.037709076,-0.04956047,-0.013771274,0.020377984,0.0068067517,0.06479833,-0.117327675,0.03578878,-0.057159357,0.016736606,-0.01111554,-0.0093289465,0.099054545,0.06499763,-0.008770597,-0.038647465,-0.026258072,0.0077831186,0.0882334,0.020540275,0.014413681,0.0065079336,0.0042816284,0.035868037,0.05051562,-0.07505758,0.010222693,-0.015628492,-0.027816512,0.036252413,0.022343677,-0.08202234,-0.03282405,0.04417535,0.027648576,-0.01178267,0.0433993,0.009768828,0.084275916,0.016215527,0.09133644,-0.06298007,0.014343593,0.053922005,-0.028638804,0.08279186,0.00012021511,-0.06353561,0.021632036,-0.010747711,0.06734244,0.037033845,0.082520895,-0.012963145,0.028993051,-0.044606335,-0.09301438,0.036830503,-0.05081147,0.05515017,0.08553846,-0.004937726,0.14546116,0.02754946,0.011795785,0.061819434,-0.025508363,0.014151523,0.0484601,0.0066139535,-0.013907949,-0.0033498227,0.06856435,0.024842942,0.04033658,0.052584752,-0.028141432,0.030684873,-0.073839635,-0.0019806772,-0.088759996,0.0048189806,0.080055065,-0.00024960688,0.040215123,0.04641252,0.0036984093,-0.06885891,-0.041532632,-0.004346816,-4.0616023e-08,0.004645693,-0.08292534,0.018924676,-0.010816806,0.059872318,0.025453312,0.09163027,0.032905545,-0.010497485,-0.005817226,-0.008775504,0.0827962,-0.00889512,0.011738584,0.009955819,-0.05737342,-0.016972313,0.071765825,-0.047162976,-0.030263914,-0.078854,0.06460549,-0.08821757,0.004303392,-0.041424066,-0.0313777,0.03140559,-0.017704504,0.10055798,-0.010077249,-0.038064793,0.09383781,-0.06097658,-0.07047555,-0.19718388,-0.03789343,0.025377184,-0.04975888,-0.07891727,0.033957545,-0.09897269,-0.030099247,-0.09087478,-0.05244918,0.030222323,-0.05047871,0.034730244,0.036411498,-0.045161843,-0.054649662,0.030094618,0.015432793,-0.020767868,-0.019759871,-0.09879821,-0.050389502,0.0054811183,-0.033524387,0.0016554598,-0.11351057,-0.05097678,0.043889128,0.19963995,0.012501047 +1.5.8.4,"A flavoprotein, containing a histidyl(Npi)-(8alpha)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel [5,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [5,9].",384,1.0,-0.028454548,-0.06141725,-0.07590033,-0.013261188,0.12070797,0.022221342,0.015005386,0.06389793,0.0608702,0.0064615053,-0.034277946,0.022698397,-0.07290647,0.057511464,-0.045140106,0.04801664,-0.13814008,-8.179615e-05,-0.07469833,-0.044756137,-0.0056855762,0.046010636,0.021084728,-0.061133355,-0.031169886,-0.072911866,0.048007168,-0.04339448,0.0001841674,-0.0032580055,0.033073712,0.033020765,0.0017250141,-0.016739473,-0.006470829,0.070894,0.00891182,-0.057576507,-0.024733754,-0.015139176,0.07097667,-0.020046111,-0.0073225885,-0.027954025,0.05927398,0.024102544,-0.0013163888,0.0565233,0.05550079,0.08306353,-0.061958045,-0.045346208,-0.06566404,0.044629693,-0.008710253,0.032108724,-0.018839985,-0.028299121,0.00076086726,0.07605417,0.051645584,-0.0129415905,0.067796215,0.009226947,0.086007446,-0.089208655,0.006992566,-0.025455944,0.011354574,-0.022666683,0.0028757986,-0.057982456,-0.044837836,0.043825388,0.04156959,0.05029633,-0.07149569,-0.01942038,0.07104664,-0.02285075,-0.008695975,-0.030363463,0.14737383,0.07769626,0.053566713,-0.037188996,-0.056236144,0.005833685,-0.018959545,0.09073877,-0.015048908,0.01681901,-0.025340224,-0.0011585684,0.011243903,0.021908551,0.05729484,-0.001859848,-0.061059114,-0.013374675,-0.049812928,-0.027371472,-0.06294758,0.005499037,-0.06273841,-0.017930338,-0.018205423,0.027825905,-0.072057344,-0.05291251,-0.034112275,-0.054762743,0.075976774,-0.08802417,0.07690443,0.05673952,-0.009990858,0.005534412,0.07630075,-0.05249448,-0.07525792,0.09783822,0.06889816,0.13724512,-0.012815054,0.03593134,-0.06633828,1.2262996e-33,0.091702364,0.04450957,-0.028026221,0.029900115,-0.010225001,-0.029346207,-0.06624088,0.014509436,0.034732837,0.024471361,-0.043805953,-0.051724967,0.016244967,-0.034126915,0.017846173,0.0062296083,-0.043862924,-0.0378794,0.05035735,-0.0551062,-0.016768835,0.041723147,0.0038663363,0.06032002,0.032668084,0.030702706,-0.040829193,0.02170424,0.012833684,0.0029778308,-0.03220631,-0.06711603,-0.07378642,-0.04517432,0.00030114735,0.011644101,-0.029114984,-0.02559785,-0.1467532,0.053492755,0.052277844,-0.023097347,-0.033001564,-0.04404127,0.031819116,-0.030089114,-0.09132255,0.0716807,0.015055811,0.010363842,0.008650431,0.0121331485,0.08879005,0.013996466,-0.10478261,-0.00514028,-0.029848091,0.003072154,0.04841427,0.0531216,0.013346459,0.0046519935,0.011877087,0.09768332,-0.02279094,0.04686194,-0.060400482,-0.06640313,0.02762371,0.093153566,0.009387428,0.03029485,0.10257881,-0.00019459809,0.077714875,-0.03671044,-0.13689932,0.0111278435,-0.009283308,0.010220995,0.03517958,-0.0067546912,-0.042437933,0.0472093,-0.025164692,-0.018863829,-0.0020816156,-0.03345592,0.00011625458,0.016219478,0.06979032,-0.09816384,0.022567227,0.034667004,0.011327375,-1.972985e-33,0.018493533,-0.08805974,0.0141717885,0.016477792,-0.034927387,0.013761443,0.075028636,-0.044368777,0.071127735,0.021184156,0.08712307,-0.059913605,0.02643469,-0.015626138,-0.009928408,0.009716577,-0.03590651,0.07454133,0.06443957,-0.00902121,-0.03619324,-0.04001626,0.038657706,0.089915894,0.030029733,-0.0048637013,-0.008602944,-0.0383337,0.009141752,0.030052667,-0.0076463344,0.04555391,-0.055846907,-0.050101493,-0.02317946,0.019144135,-0.06543453,-0.047333125,0.0025925075,-0.009247531,0.04638576,0.031590894,-0.0031308047,0.03077592,0.0153242145,0.12182292,-0.08873681,0.06400072,-0.01165765,-0.0036412387,0.006330041,0.029835744,-0.025289055,-0.009590069,0.004613942,0.07839441,0.03880562,0.055438526,0.00077750214,0.04196915,0.008852196,-0.104119316,0.0033684333,-0.032249205,0.038562767,0.06991636,-0.0050984914,0.116550334,0.015923304,0.0019146735,0.064837515,-0.07603182,0.0754247,0.074835025,0.057936322,-0.08958981,0.05940942,0.060978092,0.054593418,0.0039611896,-0.052833058,-0.0002581148,-0.00710105,-0.050166104,0.03284629,-0.066984415,0.00487906,0.058464672,0.06669324,0.04033254,0.029052962,0.04644648,-0.07520858,-0.07196325,0.009312941,-5.0473126e-08,0.07781996,-0.085601814,0.024221642,-0.05606956,0.045997515,0.021212798,0.0198532,0.018601239,-0.0067488453,0.00861338,-0.010072905,0.07608623,0.0005226988,-0.009813752,-0.014857494,-0.044750206,-0.05122394,-0.011869671,-0.016120683,-0.07299357,-0.06883328,0.027117278,-0.10283057,0.023487907,-0.027631037,-0.049712192,-0.052656207,0.007262687,0.029944178,-0.025113903,0.038180444,0.065722466,-0.025109973,-0.05597819,-0.17328931,0.065907404,0.0652578,0.00062699505,-0.06788692,0.033791967,-0.09511832,-0.07368361,-0.039774913,-0.060829066,0.027724128,-0.012979367,-0.0022694669,0.015933184,-0.06081195,-0.0060890745,-0.010397814,0.011038015,0.017572183,-0.0015001062,-0.013403597,-0.10658622,-0.04346264,-0.08867611,0.012851517,-0.10904347,-0.021592429,0.012520733,0.119351186,-0.08170285 +1.14.13.137,"The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases.",384,0.99999994,-0.08956657,0.045185424,-0.07116984,0.0059450925,0.05472243,0.1106509,-0.054169413,0.019326936,0.036379494,-0.0028503877,0.03312468,0.00576466,-0.036573704,-0.009319579,-0.0797224,0.11327604,-0.06726143,0.0067703486,-0.05517809,-0.049840376,-0.013345017,0.053698745,0.05126385,-0.008960834,0.00013063959,-0.017031442,-0.015513624,0.0299162,-0.005403956,-0.047226124,0.025489947,-0.008104287,0.09277264,-0.028070843,-0.011176155,0.070604414,-0.04825462,-0.066801734,0.05612837,0.027226374,0.01892416,-0.008601794,-0.11106006,-0.0179239,-0.05418523,-0.015172862,0.05686174,0.04442011,-0.019346358,-0.0281398,-0.0008059366,-0.027914621,-0.010675019,-0.014811429,-0.037176766,0.012359113,0.01937551,0.011408425,-0.114018194,-0.023811165,0.009478236,0.019446686,-0.06590516,0.052582897,-0.021834498,-0.036446866,0.007267147,-0.021515697,0.014367911,-0.10925715,-0.0480198,-0.109488174,-0.026717065,0.009475274,-0.096763045,0.053734507,-0.041038863,0.01779245,0.017867815,-0.04058578,0.05970968,-0.0052628466,0.01198207,0.07801451,0.056913055,0.015732171,-0.037674878,0.08798363,0.034903027,0.017313207,0.004929894,-0.118336864,-0.01306176,0.06273955,-0.056249388,0.085755594,0.05838097,-0.03908151,0.008965129,-0.030600505,0.029039444,0.01116378,0.035443313,-0.068046734,-0.048026975,0.027491465,-0.03463734,0.005330654,0.010567624,-0.085491054,-0.05735728,0.012232445,-0.019520272,0.013157093,0.000103236685,0.032001454,0.0537142,-0.058173027,-0.022006951,0.026357455,-0.017701818,-0.011718809,0.01228816,0.08232359,-0.011649001,0.07804997,-0.14416128,9.388122e-34,0.09058226,0.025302785,-0.048496135,-0.01352019,-0.011288534,0.041617863,-0.060317058,-0.02271704,-0.08060309,-0.021724742,-0.099875264,-0.081559904,0.062062655,-0.04822267,-0.030119354,0.02669645,-0.056395944,0.003703414,0.060873058,0.00018070579,-0.053105835,0.017840458,-0.1288306,0.025348397,-0.007006182,0.13473843,0.010892571,-0.019162249,-0.0046320846,0.009016076,-0.020553876,-0.07006916,-0.10006021,-0.02458234,0.073525324,0.016821472,-0.08519584,-0.04099695,-0.036662363,0.049427077,-0.052725617,-0.019302165,0.014134847,-0.008598338,0.050719954,-0.026186299,-0.13206361,0.10554373,0.072423436,0.08339789,0.03604097,-0.042610284,0.12491789,0.021030424,-0.07295866,0.032017242,0.016495176,0.041352596,0.010995406,0.032322552,0.0045709154,0.002310621,-0.06706573,0.03910546,0.038382217,-0.001216627,-0.046350878,-0.006886343,-0.033182,0.13910063,-0.02219487,-0.030718958,0.015947672,0.06785713,0.044442218,-0.03135154,0.00813866,0.023334699,0.05305695,0.0673726,-0.0040420815,-0.03569218,0.016263379,-0.07163312,-0.061659247,0.0029824849,-0.025329094,-0.013978502,-0.006644861,0.020011373,0.07212853,-0.053637944,0.0015608344,-0.00032131304,0.031742144,-3.409415e-33,0.084777,-0.031827763,0.046023227,-0.10260941,-0.01077092,0.07399269,-0.029573875,-0.04323779,-0.0060584056,0.07800023,-0.0050747255,-0.0028340756,0.021916505,-0.013069999,0.041280363,-0.021382598,0.005373954,0.06732397,0.016522625,0.018582106,-0.058497652,0.021971494,-0.0015094274,0.014285498,0.02042357,-0.0035979024,-0.03517244,0.027326135,0.029372351,0.045306776,-0.037831075,-0.00015596935,-0.057747662,-0.012826616,0.04167454,0.060176834,-0.063743144,0.040757112,0.02733556,-0.007464038,-0.04314149,0.002433049,0.07993345,0.078949474,0.062157556,0.070519686,-0.15485616,-0.010426529,-0.060821578,-0.036616575,-0.024934527,0.0924404,0.07728781,0.07329094,0.055210445,0.014005931,0.014808182,-0.026941648,-0.031817462,-0.060627628,-0.006950754,-0.020181438,-0.019707529,0.085646324,-0.024335345,0.04899298,-0.023058338,0.062749565,0.008117746,-0.008098986,-0.007440193,-0.008229229,0.0094117895,0.043032568,-0.078587025,0.03373334,-0.031381957,-0.03584651,0.009514255,-0.0126890065,0.051709894,0.022538539,-0.007389143,-0.061296053,-0.06094565,-0.09587337,-0.013370701,0.118966386,0.07017117,-0.018869007,0.011244094,0.058657747,-0.07643629,0.025453469,0.06743082,-3.5619543e-08,-0.025920304,-0.06631314,0.03891256,-0.04410777,0.016254373,-0.038517278,-0.006998082,0.008806484,0.042772915,-0.00030535943,-0.003918217,0.055876903,0.0025869957,0.017927678,0.06336476,-0.013389232,0.007709739,0.01697429,-0.006329387,0.07365781,-0.062359504,0.019238338,-0.065992065,0.028231878,0.024103777,-0.06522013,0.01028421,-0.008521297,0.046825584,0.010647573,0.031688362,0.024859885,-0.034717154,-0.00899287,-0.10317751,0.07147148,0.03846893,-0.094772816,-0.02485681,0.0019252765,-0.01529237,-0.09942998,-0.0019209916,-0.0063620443,0.02395915,0.010426683,-0.0066572283,-0.035315685,-8.839756e-05,0.020686636,-0.01658338,0.006223228,-0.0018377992,-0.06112711,-0.1264742,0.0019714355,0.046514623,-0.06879792,0.0040937136,-0.07686691,-0.063020416,0.054029264,0.22259158,-0.012736366 +1.14.13.138,"The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases.",384,0.99999994,-0.08956657,0.045185424,-0.07116984,0.0059450925,0.05472243,0.1106509,-0.054169413,0.019326936,0.036379494,-0.0028503877,0.03312468,0.00576466,-0.036573704,-0.009319579,-0.0797224,0.11327604,-0.06726143,0.0067703486,-0.05517809,-0.049840376,-0.013345017,0.053698745,0.05126385,-0.008960834,0.00013063959,-0.017031442,-0.015513624,0.0299162,-0.005403956,-0.047226124,0.025489947,-0.008104287,0.09277264,-0.028070843,-0.011176155,0.070604414,-0.04825462,-0.066801734,0.05612837,0.027226374,0.01892416,-0.008601794,-0.11106006,-0.0179239,-0.05418523,-0.015172862,0.05686174,0.04442011,-0.019346358,-0.0281398,-0.0008059366,-0.027914621,-0.010675019,-0.014811429,-0.037176766,0.012359113,0.01937551,0.011408425,-0.114018194,-0.023811165,0.009478236,0.019446686,-0.06590516,0.052582897,-0.021834498,-0.036446866,0.007267147,-0.021515697,0.014367911,-0.10925715,-0.0480198,-0.109488174,-0.026717065,0.009475274,-0.096763045,0.053734507,-0.041038863,0.01779245,0.017867815,-0.04058578,0.05970968,-0.0052628466,0.01198207,0.07801451,0.056913055,0.015732171,-0.037674878,0.08798363,0.034903027,0.017313207,0.004929894,-0.118336864,-0.01306176,0.06273955,-0.056249388,0.085755594,0.05838097,-0.03908151,0.008965129,-0.030600505,0.029039444,0.01116378,0.035443313,-0.068046734,-0.048026975,0.027491465,-0.03463734,0.005330654,0.010567624,-0.085491054,-0.05735728,0.012232445,-0.019520272,0.013157093,0.000103236685,0.032001454,0.0537142,-0.058173027,-0.022006951,0.026357455,-0.017701818,-0.011718809,0.01228816,0.08232359,-0.011649001,0.07804997,-0.14416128,9.388122e-34,0.09058226,0.025302785,-0.048496135,-0.01352019,-0.011288534,0.041617863,-0.060317058,-0.02271704,-0.08060309,-0.021724742,-0.099875264,-0.081559904,0.062062655,-0.04822267,-0.030119354,0.02669645,-0.056395944,0.003703414,0.060873058,0.00018070579,-0.053105835,0.017840458,-0.1288306,0.025348397,-0.007006182,0.13473843,0.010892571,-0.019162249,-0.0046320846,0.009016076,-0.020553876,-0.07006916,-0.10006021,-0.02458234,0.073525324,0.016821472,-0.08519584,-0.04099695,-0.036662363,0.049427077,-0.052725617,-0.019302165,0.014134847,-0.008598338,0.050719954,-0.026186299,-0.13206361,0.10554373,0.072423436,0.08339789,0.03604097,-0.042610284,0.12491789,0.021030424,-0.07295866,0.032017242,0.016495176,0.041352596,0.010995406,0.032322552,0.0045709154,0.002310621,-0.06706573,0.03910546,0.038382217,-0.001216627,-0.046350878,-0.006886343,-0.033182,0.13910063,-0.02219487,-0.030718958,0.015947672,0.06785713,0.044442218,-0.03135154,0.00813866,0.023334699,0.05305695,0.0673726,-0.0040420815,-0.03569218,0.016263379,-0.07163312,-0.061659247,0.0029824849,-0.025329094,-0.013978502,-0.006644861,0.020011373,0.07212853,-0.053637944,0.0015608344,-0.00032131304,0.031742144,-3.409415e-33,0.084777,-0.031827763,0.046023227,-0.10260941,-0.01077092,0.07399269,-0.029573875,-0.04323779,-0.0060584056,0.07800023,-0.0050747255,-0.0028340756,0.021916505,-0.013069999,0.041280363,-0.021382598,0.005373954,0.06732397,0.016522625,0.018582106,-0.058497652,0.021971494,-0.0015094274,0.014285498,0.02042357,-0.0035979024,-0.03517244,0.027326135,0.029372351,0.045306776,-0.037831075,-0.00015596935,-0.057747662,-0.012826616,0.04167454,0.060176834,-0.063743144,0.040757112,0.02733556,-0.007464038,-0.04314149,0.002433049,0.07993345,0.078949474,0.062157556,0.070519686,-0.15485616,-0.010426529,-0.060821578,-0.036616575,-0.024934527,0.0924404,0.07728781,0.07329094,0.055210445,0.014005931,0.014808182,-0.026941648,-0.031817462,-0.060627628,-0.006950754,-0.020181438,-0.019707529,0.085646324,-0.024335345,0.04899298,-0.023058338,0.062749565,0.008117746,-0.008098986,-0.007440193,-0.008229229,0.0094117895,0.043032568,-0.078587025,0.03373334,-0.031381957,-0.03584651,0.009514255,-0.0126890065,0.051709894,0.022538539,-0.007389143,-0.061296053,-0.06094565,-0.09587337,-0.013370701,0.118966386,0.07017117,-0.018869007,0.011244094,0.058657747,-0.07643629,0.025453469,0.06743082,-3.5619543e-08,-0.025920304,-0.06631314,0.03891256,-0.04410777,0.016254373,-0.038517278,-0.006998082,0.008806484,0.042772915,-0.00030535943,-0.003918217,0.055876903,0.0025869957,0.017927678,0.06336476,-0.013389232,0.007709739,0.01697429,-0.006329387,0.07365781,-0.062359504,0.019238338,-0.065992065,0.028231878,0.024103777,-0.06522013,0.01028421,-0.008521297,0.046825584,0.010647573,0.031688362,0.024859885,-0.034717154,-0.00899287,-0.10317751,0.07147148,0.03846893,-0.094772816,-0.02485681,0.0019252765,-0.01529237,-0.09942998,-0.0019209916,-0.0063620443,0.02395915,0.010426683,-0.0066572283,-0.035315685,-8.839756e-05,0.020686636,-0.01658338,0.006223228,-0.0018377992,-0.06112711,-0.1264742,0.0019714355,0.046514623,-0.06879792,0.0040937136,-0.07686691,-0.063020416,0.054029264,0.22259158,-0.012736366 +1.14.13.139,"The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases.",384,0.99999994,-0.08956657,0.045185424,-0.07116984,0.0059450925,0.05472243,0.1106509,-0.054169413,0.019326936,0.036379494,-0.0028503877,0.03312468,0.00576466,-0.036573704,-0.009319579,-0.0797224,0.11327604,-0.06726143,0.0067703486,-0.05517809,-0.049840376,-0.013345017,0.053698745,0.05126385,-0.008960834,0.00013063959,-0.017031442,-0.015513624,0.0299162,-0.005403956,-0.047226124,0.025489947,-0.008104287,0.09277264,-0.028070843,-0.011176155,0.070604414,-0.04825462,-0.066801734,0.05612837,0.027226374,0.01892416,-0.008601794,-0.11106006,-0.0179239,-0.05418523,-0.015172862,0.05686174,0.04442011,-0.019346358,-0.0281398,-0.0008059366,-0.027914621,-0.010675019,-0.014811429,-0.037176766,0.012359113,0.01937551,0.011408425,-0.114018194,-0.023811165,0.009478236,0.019446686,-0.06590516,0.052582897,-0.021834498,-0.036446866,0.007267147,-0.021515697,0.014367911,-0.10925715,-0.0480198,-0.109488174,-0.026717065,0.009475274,-0.096763045,0.053734507,-0.041038863,0.01779245,0.017867815,-0.04058578,0.05970968,-0.0052628466,0.01198207,0.07801451,0.056913055,0.015732171,-0.037674878,0.08798363,0.034903027,0.017313207,0.004929894,-0.118336864,-0.01306176,0.06273955,-0.056249388,0.085755594,0.05838097,-0.03908151,0.008965129,-0.030600505,0.029039444,0.01116378,0.035443313,-0.068046734,-0.048026975,0.027491465,-0.03463734,0.005330654,0.010567624,-0.085491054,-0.05735728,0.012232445,-0.019520272,0.013157093,0.000103236685,0.032001454,0.0537142,-0.058173027,-0.022006951,0.026357455,-0.017701818,-0.011718809,0.01228816,0.08232359,-0.011649001,0.07804997,-0.14416128,9.388122e-34,0.09058226,0.025302785,-0.048496135,-0.01352019,-0.011288534,0.041617863,-0.060317058,-0.02271704,-0.08060309,-0.021724742,-0.099875264,-0.081559904,0.062062655,-0.04822267,-0.030119354,0.02669645,-0.056395944,0.003703414,0.060873058,0.00018070579,-0.053105835,0.017840458,-0.1288306,0.025348397,-0.007006182,0.13473843,0.010892571,-0.019162249,-0.0046320846,0.009016076,-0.020553876,-0.07006916,-0.10006021,-0.02458234,0.073525324,0.016821472,-0.08519584,-0.04099695,-0.036662363,0.049427077,-0.052725617,-0.019302165,0.014134847,-0.008598338,0.050719954,-0.026186299,-0.13206361,0.10554373,0.072423436,0.08339789,0.03604097,-0.042610284,0.12491789,0.021030424,-0.07295866,0.032017242,0.016495176,0.041352596,0.010995406,0.032322552,0.0045709154,0.002310621,-0.06706573,0.03910546,0.038382217,-0.001216627,-0.046350878,-0.006886343,-0.033182,0.13910063,-0.02219487,-0.030718958,0.015947672,0.06785713,0.044442218,-0.03135154,0.00813866,0.023334699,0.05305695,0.0673726,-0.0040420815,-0.03569218,0.016263379,-0.07163312,-0.061659247,0.0029824849,-0.025329094,-0.013978502,-0.006644861,0.020011373,0.07212853,-0.053637944,0.0015608344,-0.00032131304,0.031742144,-3.409415e-33,0.084777,-0.031827763,0.046023227,-0.10260941,-0.01077092,0.07399269,-0.029573875,-0.04323779,-0.0060584056,0.07800023,-0.0050747255,-0.0028340756,0.021916505,-0.013069999,0.041280363,-0.021382598,0.005373954,0.06732397,0.016522625,0.018582106,-0.058497652,0.021971494,-0.0015094274,0.014285498,0.02042357,-0.0035979024,-0.03517244,0.027326135,0.029372351,0.045306776,-0.037831075,-0.00015596935,-0.057747662,-0.012826616,0.04167454,0.060176834,-0.063743144,0.040757112,0.02733556,-0.007464038,-0.04314149,0.002433049,0.07993345,0.078949474,0.062157556,0.070519686,-0.15485616,-0.010426529,-0.060821578,-0.036616575,-0.024934527,0.0924404,0.07728781,0.07329094,0.055210445,0.014005931,0.014808182,-0.026941648,-0.031817462,-0.060627628,-0.006950754,-0.020181438,-0.019707529,0.085646324,-0.024335345,0.04899298,-0.023058338,0.062749565,0.008117746,-0.008098986,-0.007440193,-0.008229229,0.0094117895,0.043032568,-0.078587025,0.03373334,-0.031381957,-0.03584651,0.009514255,-0.0126890065,0.051709894,0.022538539,-0.007389143,-0.061296053,-0.06094565,-0.09587337,-0.013370701,0.118966386,0.07017117,-0.018869007,0.011244094,0.058657747,-0.07643629,0.025453469,0.06743082,-3.5619543e-08,-0.025920304,-0.06631314,0.03891256,-0.04410777,0.016254373,-0.038517278,-0.006998082,0.008806484,0.042772915,-0.00030535943,-0.003918217,0.055876903,0.0025869957,0.017927678,0.06336476,-0.013389232,0.007709739,0.01697429,-0.006329387,0.07365781,-0.062359504,0.019238338,-0.065992065,0.028231878,0.024103777,-0.06522013,0.01028421,-0.008521297,0.046825584,0.010647573,0.031688362,0.024859885,-0.034717154,-0.00899287,-0.10317751,0.07147148,0.03846893,-0.094772816,-0.02485681,0.0019252765,-0.01529237,-0.09942998,-0.0019209916,-0.0063620443,0.02395915,0.010426683,-0.0066572283,-0.035315685,-8.839756e-05,0.020686636,-0.01658338,0.006223228,-0.0018377992,-0.06112711,-0.1264742,0.0019714355,0.046514623,-0.06879792,0.0040937136,-0.07686691,-0.063020416,0.054029264,0.22259158,-0.012736366 +1.14.13.140,"The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases.",384,0.99999994,-0.08956657,0.045185424,-0.07116984,0.0059450925,0.05472243,0.1106509,-0.054169413,0.019326936,0.036379494,-0.0028503877,0.03312468,0.00576466,-0.036573704,-0.009319579,-0.0797224,0.11327604,-0.06726143,0.0067703486,-0.05517809,-0.049840376,-0.013345017,0.053698745,0.05126385,-0.008960834,0.00013063959,-0.017031442,-0.015513624,0.0299162,-0.005403956,-0.047226124,0.025489947,-0.008104287,0.09277264,-0.028070843,-0.011176155,0.070604414,-0.04825462,-0.066801734,0.05612837,0.027226374,0.01892416,-0.008601794,-0.11106006,-0.0179239,-0.05418523,-0.015172862,0.05686174,0.04442011,-0.019346358,-0.0281398,-0.0008059366,-0.027914621,-0.010675019,-0.014811429,-0.037176766,0.012359113,0.01937551,0.011408425,-0.114018194,-0.023811165,0.009478236,0.019446686,-0.06590516,0.052582897,-0.021834498,-0.036446866,0.007267147,-0.021515697,0.014367911,-0.10925715,-0.0480198,-0.109488174,-0.026717065,0.009475274,-0.096763045,0.053734507,-0.041038863,0.01779245,0.017867815,-0.04058578,0.05970968,-0.0052628466,0.01198207,0.07801451,0.056913055,0.015732171,-0.037674878,0.08798363,0.034903027,0.017313207,0.004929894,-0.118336864,-0.01306176,0.06273955,-0.056249388,0.085755594,0.05838097,-0.03908151,0.008965129,-0.030600505,0.029039444,0.01116378,0.035443313,-0.068046734,-0.048026975,0.027491465,-0.03463734,0.005330654,0.010567624,-0.085491054,-0.05735728,0.012232445,-0.019520272,0.013157093,0.000103236685,0.032001454,0.0537142,-0.058173027,-0.022006951,0.026357455,-0.017701818,-0.011718809,0.01228816,0.08232359,-0.011649001,0.07804997,-0.14416128,9.388122e-34,0.09058226,0.025302785,-0.048496135,-0.01352019,-0.011288534,0.041617863,-0.060317058,-0.02271704,-0.08060309,-0.021724742,-0.099875264,-0.081559904,0.062062655,-0.04822267,-0.030119354,0.02669645,-0.056395944,0.003703414,0.060873058,0.00018070579,-0.053105835,0.017840458,-0.1288306,0.025348397,-0.007006182,0.13473843,0.010892571,-0.019162249,-0.0046320846,0.009016076,-0.020553876,-0.07006916,-0.10006021,-0.02458234,0.073525324,0.016821472,-0.08519584,-0.04099695,-0.036662363,0.049427077,-0.052725617,-0.019302165,0.014134847,-0.008598338,0.050719954,-0.026186299,-0.13206361,0.10554373,0.072423436,0.08339789,0.03604097,-0.042610284,0.12491789,0.021030424,-0.07295866,0.032017242,0.016495176,0.041352596,0.010995406,0.032322552,0.0045709154,0.002310621,-0.06706573,0.03910546,0.038382217,-0.001216627,-0.046350878,-0.006886343,-0.033182,0.13910063,-0.02219487,-0.030718958,0.015947672,0.06785713,0.044442218,-0.03135154,0.00813866,0.023334699,0.05305695,0.0673726,-0.0040420815,-0.03569218,0.016263379,-0.07163312,-0.061659247,0.0029824849,-0.025329094,-0.013978502,-0.006644861,0.020011373,0.07212853,-0.053637944,0.0015608344,-0.00032131304,0.031742144,-3.409415e-33,0.084777,-0.031827763,0.046023227,-0.10260941,-0.01077092,0.07399269,-0.029573875,-0.04323779,-0.0060584056,0.07800023,-0.0050747255,-0.0028340756,0.021916505,-0.013069999,0.041280363,-0.021382598,0.005373954,0.06732397,0.016522625,0.018582106,-0.058497652,0.021971494,-0.0015094274,0.014285498,0.02042357,-0.0035979024,-0.03517244,0.027326135,0.029372351,0.045306776,-0.037831075,-0.00015596935,-0.057747662,-0.012826616,0.04167454,0.060176834,-0.063743144,0.040757112,0.02733556,-0.007464038,-0.04314149,0.002433049,0.07993345,0.078949474,0.062157556,0.070519686,-0.15485616,-0.010426529,-0.060821578,-0.036616575,-0.024934527,0.0924404,0.07728781,0.07329094,0.055210445,0.014005931,0.014808182,-0.026941648,-0.031817462,-0.060627628,-0.006950754,-0.020181438,-0.019707529,0.085646324,-0.024335345,0.04899298,-0.023058338,0.062749565,0.008117746,-0.008098986,-0.007440193,-0.008229229,0.0094117895,0.043032568,-0.078587025,0.03373334,-0.031381957,-0.03584651,0.009514255,-0.0126890065,0.051709894,0.022538539,-0.007389143,-0.061296053,-0.06094565,-0.09587337,-0.013370701,0.118966386,0.07017117,-0.018869007,0.011244094,0.058657747,-0.07643629,0.025453469,0.06743082,-3.5619543e-08,-0.025920304,-0.06631314,0.03891256,-0.04410777,0.016254373,-0.038517278,-0.006998082,0.008806484,0.042772915,-0.00030535943,-0.003918217,0.055876903,0.0025869957,0.017927678,0.06336476,-0.013389232,0.007709739,0.01697429,-0.006329387,0.07365781,-0.062359504,0.019238338,-0.065992065,0.028231878,0.024103777,-0.06522013,0.01028421,-0.008521297,0.046825584,0.010647573,0.031688362,0.024859885,-0.034717154,-0.00899287,-0.10317751,0.07147148,0.03846893,-0.094772816,-0.02485681,0.0019252765,-0.01529237,-0.09942998,-0.0019209916,-0.0063620443,0.02395915,0.010426683,-0.0066572283,-0.035315685,-8.839756e-05,0.020686636,-0.01658338,0.006223228,-0.0018377992,-0.06112711,-0.1264742,0.0019714355,0.046514623,-0.06879792,0.0040937136,-0.07686691,-0.063020416,0.054029264,0.22259158,-0.012736366 +1.14.13.141,"This enzyme, found in several bacterial pathogens, is involved in degradation of the host's cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol [4]. The products are exclusively in the (25S) configuration. It is a two-component system consisting of a P-450 (heme thiolate) oxygenase (Cyp125) and a ferredoxin reductase (most likely KshB, which is also a part of EC 1.14.13.142, 3-ketosteroid 9alpha-monooxygenase). The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.15.28, cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming].",384,0.9999999,-0.057079904,-0.009199496,-0.09117827,-0.01590945,0.03590616,0.052269366,-0.10411218,0.057820026,0.010621233,-0.06987675,-0.035252895,-0.018210419,-0.017119402,-0.0035781115,-0.064358726,0.039907627,-0.08564176,-0.019387236,0.008755822,-0.025019797,-0.03150536,-0.012940874,-0.014207471,-0.021817394,-0.065375485,0.030000113,0.053277265,-0.028646614,-0.11261505,-0.110092886,0.051434487,-0.05611504,0.08904033,-0.03833028,0.009020275,0.028696358,-0.03005342,-0.045277286,0.030824922,-0.01965202,0.023071706,-0.020486347,-0.0039403196,0.010101717,0.00848554,-0.051625684,-0.039315764,0.040475555,-0.0103326095,0.009362841,-0.037525866,-0.0603993,-0.015470254,0.056005526,0.067582145,-0.0069129933,-0.06998498,-0.031088842,0.019804237,-0.03032701,0.029593492,0.011926752,0.008783632,-0.008934725,-0.06802196,-0.09165381,0.0058501307,-0.07605291,-0.039256364,-0.062037252,-0.08018318,-0.07994527,-0.051299773,0.024702117,-0.016703254,0.06586328,0.0035387466,-0.07819971,0.06164056,-0.004575109,0.024897108,0.011121408,-0.0006371158,0.08852637,0.05755582,-0.027863467,-0.022356767,-0.022161094,-0.026355756,0.015310045,0.029063089,-0.0022354738,-0.034578774,-0.028002799,-0.030878194,-0.008247583,0.04981699,0.06273034,0.019964758,0.01295109,0.0138209965,0.06119917,0.007767401,-0.12073322,-0.072568424,-0.031951007,0.03926779,0.111260876,0.050348263,-0.021776207,-0.011193583,-0.017677274,0.024273112,-0.05033921,0.053712297,0.15782787,-0.00019806504,-0.060483478,-0.05245171,0.040272273,0.03948731,1.6634809e-07,0.04510934,0.035095274,-0.050692234,-0.009674503,-0.07483599,4.828506e-34,0.024271468,-0.033286143,0.010971265,0.014486677,0.016224599,0.0039858767,-0.06193715,0.027593084,-0.030807352,-0.052490707,-0.00408313,-0.086780235,0.08488502,-0.026279878,-0.030569742,-0.03047518,-0.030841984,-0.005959923,0.032001525,0.0093080485,-0.00471179,0.023346083,-0.076136805,0.015137562,0.00945012,0.032786943,0.009003187,0.044061523,0.017095672,0.0154339485,-0.011203704,-0.02226183,-0.11833458,-0.032794822,0.024843346,-0.00081208977,-0.06189816,0.023104116,-0.050658744,0.044526298,0.040653624,-0.011001429,-0.03153039,-0.04398181,0.10270173,-0.03209954,-0.01684881,0.114862375,0.06752244,0.057083566,0.048938315,-0.034587286,0.10944379,0.047640484,0.017156653,0.1182581,0.0004323958,-0.00016127332,0.018877247,0.0305119,0.097158484,0.06826331,-0.08674142,0.023129623,0.016522514,0.033060484,-0.034814958,-0.068349384,-0.07234261,0.10729897,-0.002602606,0.0653804,0.054676533,-0.022165025,-0.0038755974,-0.007255751,-0.04444261,0.057373155,0.025121806,-0.054299302,0.012911788,-0.0019698748,0.02326937,-0.06303948,-0.02252672,0.0075162887,-0.0747357,-0.011794996,-0.04495282,0.084817015,0.070688665,-0.11553978,-0.12234287,0.026717285,-0.039793663,-1.559062e-33,0.05790536,-0.07883553,0.022743834,-0.10219774,-0.006801233,0.086225644,0.06861857,0.030307967,0.046345886,-0.062265694,0.070962146,0.009594946,0.057608817,-0.006272589,0.0893076,0.06284807,-0.080890626,0.04330509,-0.013602113,-0.0006823391,-0.009363114,0.06608028,-0.022737056,0.09983708,0.032566812,0.067609526,-0.01230512,0.027141312,0.102469146,0.05104766,-0.012543835,-0.026134573,-0.029860906,-0.039753314,-0.06584664,0.07546227,-0.047851734,-0.02586718,0.010681834,0.010673796,-0.047602996,0.058991022,0.0055802613,0.012905243,0.04196398,0.11651945,-0.053259358,0.0327828,0.04588417,-0.06461729,-0.01858605,-0.016983317,-0.032986797,0.06726656,-0.028262457,0.08900744,0.031031908,0.0314538,0.035239052,-0.08933955,-0.055266708,-0.0250764,0.032587033,0.033149697,0.00950786,0.02399473,-0.013167867,0.03696755,0.047629908,-0.0067341086,-0.0017611645,0.06934549,-0.019683907,0.0335037,0.014495852,-0.020421572,-0.0075607477,0.0088312095,-0.0053508654,-0.00041461113,0.014957952,-0.021544548,0.0214629,-0.07300432,-0.014412119,-0.12915519,-0.004122131,0.06519153,0.046577387,0.039880164,0.006269476,0.01398328,-0.11318364,0.08104229,0.03502524,-4.7399528e-08,0.034730315,-0.11854952,-0.0006174966,-0.029238392,-0.021726383,0.036214326,0.05582456,0.0159023,0.047442604,-0.051830556,0.0062779044,0.14614637,0.009358285,-0.036874775,0.010151297,0.012454166,-0.04583652,-0.028199522,0.0111414995,0.0029807887,-0.008319938,-0.04072393,0.0081107775,0.054603502,-0.011274444,-0.046525694,-0.01765631,0.05735419,-8.800069e-05,-0.04121016,-0.022979537,0.07249381,0.005413089,-0.0041750283,-0.033300944,0.026443074,-0.07307638,-0.03877625,-0.0086804135,0.10609051,0.027418988,-0.043527603,-0.0762274,-0.02809218,0.0107675735,-0.016374113,-0.02789595,0.042760484,0.0046296194,-0.042242285,-0.0690971,0.051117457,-0.031703528,0.025793914,-0.079903625,0.03001762,-0.0050977627,-0.08755077,0.015501079,-0.049664155,0.013897468,0.05032672,0.22939754,0.03077694 +1.14.13.142,"The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It is a two-component system consisting of a terminal oxygenase (KshA) and a ferredoxin reductase (KshB). The oxygenase contains a Rieske-type iron-sulfur center and non-heme iron. The reductase component is a flavoprotein containing an NAD-binding domain and a plant-type iron-sulfur cluster. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.",384,1.0,-0.062962785,-0.04676248,-0.1260233,0.0015901562,0.07762123,0.061252553,-0.049656928,0.093114085,0.025653804,-0.08091296,-0.048359346,0.006287482,0.02511434,0.0036114745,-0.06598779,0.019034881,-0.056928657,-0.014402825,-0.027908444,-0.02218071,-0.01624909,0.046992596,-0.0069208075,-0.06815867,-0.027236788,0.018671213,0.07507611,-0.061564684,-0.11383391,-0.09185621,0.020265711,-0.050849143,0.04543817,-0.043063745,0.011849566,0.07023419,0.019247135,-0.03666066,0.01897913,0.02989497,0.039328866,-0.004934248,0.010963834,-0.0104830265,0.031432517,-0.010540588,-0.07935429,0.032615814,0.042164456,0.03867379,-0.070951484,-0.050174758,-0.065325834,0.09973823,0.078162536,-0.016218081,-0.020727132,-0.037834305,0.0075206403,-0.024342721,0.06747439,-0.029151412,0.035288405,0.02903103,-0.0096481,-0.03856003,0.011257705,-0.0487823,-0.025700828,-0.08871631,-0.085289136,-0.043977883,-0.124999896,0.04958428,0.028310722,0.049668994,-0.009526034,-0.04614405,0.0457673,0.0108022075,0.025060128,-0.007926929,0.003176735,0.08984642,0.04920372,0.025476227,-0.004213789,-0.033313803,-0.008033914,0.028901158,0.031636257,-0.0134780295,0.0290187,0.0020196429,-0.09843985,-0.017662574,0.03606453,0.036594875,-0.035024755,0.003978819,-0.034731854,0.041059464,0.0025641927,-0.08289247,-0.06566917,-0.0404147,-0.034878597,0.08015092,0.039507937,-0.0070591345,0.012431299,-0.021556105,0.054118995,-0.05986667,0.015481218,0.116091944,0.07436732,-0.036227304,-0.11124269,0.053530954,0.07260987,-0.015834019,0.008965225,0.033867072,-0.062415887,-0.017879289,-0.10113515,-4.0813136e-34,0.058008906,-0.049836233,0.05357817,-0.020927025,0.0095389085,-0.031893045,-0.103700444,-0.0051690596,-0.016474286,-0.036576886,-0.017823882,-0.06294571,0.027437322,-0.028043322,-0.05407779,0.0024153101,-0.02112374,0.0035707583,0.045208495,0.00028519772,0.027131954,0.05926175,-0.028510496,0.040348925,0.051961154,0.05526833,-0.010538587,0.04510928,-0.029441217,0.005407899,-0.0011613622,-0.0834132,-0.12478408,-0.017010164,0.015450169,-0.01720538,-0.066373594,-0.03434677,-0.015929172,0.05096318,-0.009878721,-0.016288606,-0.028206512,-0.011884453,0.09593518,-0.051882535,-0.052061763,0.09179458,0.030515147,0.06680505,0.010558644,-0.044220865,0.122525096,0.08946139,-0.010839985,0.048583485,0.005379117,0.027619548,0.00014629797,0.021073248,0.08659869,0.06802258,-0.0580507,0.07839996,-0.040466867,-0.02596191,-0.072761014,-0.039960086,-0.0073384726,0.076692365,0.0019906412,0.071713924,0.030187612,-0.009265542,0.043172278,-0.05742343,-0.0771693,0.0036821254,0.014925105,-0.03932995,0.020856451,-0.042794835,-0.017727122,-0.049517423,-0.06014959,-0.013610357,-0.057164054,-0.029175235,-0.076015525,-0.017064678,0.05678114,-0.0292374,-0.10566512,-0.013790788,-0.016376186,-3.330034e-34,0.068480015,-0.09709485,0.04142744,-0.07070453,0.021182816,0.04029243,0.06020874,0.029521357,0.015321724,-0.019483954,0.04842242,-0.0051528327,0.004750548,-0.05030808,0.08894128,0.06964082,-0.012533653,0.04039636,-0.0072276816,-0.03412928,-0.029093683,0.051338006,0.020959955,0.058386806,-0.014370046,0.033129383,-0.03064775,0.03531122,0.08722572,0.10543028,-0.010695222,-0.0032867948,-0.05846671,-0.024912935,-0.13255426,0.025236862,-0.053205602,-0.010001142,0.047664322,-0.017056275,0.010202321,0.059404455,-0.0047398005,0.034746543,0.06005937,0.09641644,-0.06117467,0.074239835,0.08151131,-0.06720372,0.0060322518,5.3991007e-05,0.01898561,0.059734877,0.008061862,0.07414939,0.041929923,0.033925213,0.00039556215,-0.035926763,-0.055592548,-0.05431425,0.03357065,0.04405186,0.041503716,0.08632697,0.058446318,0.05755317,0.047959823,-0.018560866,0.05045144,0.056093358,0.020229165,0.022507137,0.016663525,-0.07553369,-0.05176208,0.07453576,-0.0109261,0.029309113,-0.048484884,-0.00904958,0.020492973,-0.058986865,0.032311685,-0.10284855,-0.021225592,0.088883236,0.045996487,0.029656548,-0.04102093,0.035467573,-0.09018452,0.0313772,0.037359763,-4.2104052e-08,0.061155874,-0.10819612,0.019712677,-0.049853645,0.0030725303,-0.0038063452,0.04272887,0.011840426,0.04333995,-0.0009549944,0.04696986,0.17203167,-0.0010157493,-0.050920457,0.08856487,0.027233813,-0.0025145973,0.0066693183,-0.0048649064,-0.012437108,0.00030389725,-0.033653833,-0.049080532,0.051095344,-0.01241785,-0.011724983,0.0044986573,0.04891844,0.032367382,-0.036254864,-0.02745324,0.03816387,0.004611392,-0.02426143,-0.15030581,0.0028706512,-0.049862713,-0.019555582,0.027703118,0.0609397,-0.034153525,0.0060917097,-0.07469998,0.009707336,-0.0055190255,0.0059291646,0.0068578585,0.03964847,0.0071677947,-0.064615555,-0.04396781,0.022517337,-0.053509302,0.0025893063,-0.10206225,0.06767682,0.005969177,-0.040692516,0.007092629,-0.042632528,0.006699274,0.024731802,0.19429702,0.015611964 +1.14.13.143,This cytochrome P-450 (heme thiolate) enzyme has been characterized from the plant Oryza sativa (rice). It may be involved in production of oryzadione.,384,1.0,-0.09479185,0.025900953,-0.048995968,-0.0152056785,0.011657093,0.07388828,-0.041261755,0.069907226,-0.04847089,0.0035216429,0.07114976,-0.00497852,-0.006183486,0.030179735,-0.044298142,0.054025456,-0.0032045648,0.0023898075,-0.07445077,-0.09133548,0.021801522,0.06588603,0.03154501,0.035442937,0.009358168,-0.033419207,0.0060830885,0.07328303,0.001700349,-0.06106658,-0.0678402,0.023551162,0.03346533,-0.010913311,0.04584355,0.045139823,-0.034074146,-0.07417671,-2.1334046e-05,-0.034007557,0.08337477,-0.05917362,-0.08481778,0.0042662574,-0.042859357,-0.08349831,-0.010346457,-0.033447616,0.01951288,-0.05323825,-0.017156282,-0.02505349,-0.043212168,0.023515455,-0.09419871,-0.019875506,0.051580355,0.00818189,-0.0771803,0.01913329,-0.038755022,0.055787876,-0.056861978,0.048308976,-0.028460067,0.020643784,-0.04894524,-0.03558466,-0.0074335416,-0.072668575,0.022283696,-0.111620225,-0.033717114,0.07480942,-0.09131469,-0.004694918,0.046632092,0.013633398,-0.0012164564,-0.049514398,0.039607752,0.015031223,-0.0041437685,0.09547538,-0.0127072465,0.017736616,-0.07612131,0.1202156,0.0335691,-0.07065968,0.017002264,0.032008585,-0.045257553,-0.019024974,-0.0832359,0.08045356,-0.0038028308,-0.035664357,0.037332434,-0.031071277,0.0696587,0.05453906,-0.052495945,-0.10213075,-0.05253722,0.01455368,0.0027467576,-0.006869095,0.03779922,-0.044665176,-0.035494022,-0.038590334,0.011016967,0.024734685,-0.056177296,0.064042024,-0.023892382,-8.3232764e-05,-0.004946701,-0.07557511,0.0022872437,-0.026583666,-0.013296505,0.038277272,-0.014945194,0.02414681,-0.08760991,1.7373305e-33,0.06690404,0.05201439,0.031927496,-0.04091308,-0.004095651,0.026012352,-0.010550605,0.026851669,-0.05443742,-0.023285283,-0.10326807,-0.09928525,-0.029470855,-0.026122542,-0.0028593242,-0.025100753,-0.061349224,0.05138161,0.022992397,0.056227002,-0.027049787,0.022090618,-0.09919977,0.0017818534,0.01795613,0.07973211,0.018131573,-0.02151911,-0.00858947,-0.02355089,0.016457267,-0.04612428,-0.057806693,-0.074552335,-0.030025288,-0.033705812,0.00054134603,0.027070343,-0.047175433,0.07400495,-0.014909746,0.023828346,0.03857144,-0.050659,0.047296546,0.0025351006,-0.114754066,0.081373945,0.005967223,0.05796351,0.0338055,-0.04656861,0.09328496,0.07844958,-0.021260304,0.016158415,0.027562324,0.044087514,0.02041187,0.023498053,0.10021167,0.027006077,-0.040726982,0.061699226,0.030675314,0.0123225385,-0.07770465,-0.04191861,0.007659169,0.12920868,-0.058739062,-0.051531557,-0.008323901,-0.01334435,0.04927325,-0.041876443,-0.021964941,0.0558209,0.053559944,0.033328336,0.018786581,-0.021487907,0.020225797,-0.012420304,-0.03531423,0.009656984,-0.006584079,0.04853571,-0.048891716,0.040771555,0.08790276,-0.03604377,0.028207438,0.016717158,-0.011839198,-2.2332525e-33,0.061552882,-0.03731082,0.03096859,-0.06284895,-0.008879332,-0.012603167,-0.019288028,0.031988367,0.04183146,0.037724327,0.097953774,-0.023195725,0.04335516,-0.0438893,-0.022734074,0.05585271,0.00508785,0.07831909,-0.028860645,0.06072329,-0.077113084,0.054258585,0.005215622,-0.015032939,0.03556208,0.015209633,0.032537356,0.037724286,-0.0018586173,0.047501113,-0.007702153,-0.003453873,-0.085171424,-0.03559822,0.0028683462,0.03483349,0.027884308,-0.039181173,0.033245888,0.045829933,-0.07625355,0.11517389,0.06089823,0.055805467,-0.022426696,0.07120175,-0.1036954,-0.028020956,-0.032596163,-0.029822847,-0.007836049,-0.0013444619,0.0055313325,0.025225392,-0.032443624,0.0073856493,-0.017777396,-0.012396728,-0.09141165,-0.09391107,0.022998257,-0.020620126,-0.0055960976,0.0372177,-0.0064026117,0.12111542,-0.027724456,0.040696155,0.005828395,0.009584737,-0.010098399,-0.014855536,0.0021429907,0.11230854,-0.04272835,0.019640451,-0.020061268,-0.048189424,0.041034427,0.0154808415,0.008497334,0.007883941,-0.09190216,-0.0643907,-0.016408386,-0.068296105,-0.076216,0.16637187,0.09089637,0.0013652869,-0.0046372153,0.033613306,-0.051530413,0.07851126,0.07611074,-3.0576405e-08,-0.002641927,-0.17429024,0.02043191,-0.014445609,-0.010809036,-0.044721365,0.034775987,-0.0022178285,0.12147554,-0.034305997,-0.05158366,0.072246954,-0.05230958,0.014048278,0.01145943,-0.0007917124,0.09896682,0.07062001,0.03563258,-0.023032118,0.004899906,-0.02482999,-0.04134211,0.02367094,0.041948434,-0.023667624,-0.03731143,0.018995443,0.085902244,-0.010013203,0.0041624354,0.02423787,-0.009264717,-0.026044216,0.04055393,0.0949364,-0.015651904,-0.058938295,0.0052876053,-0.04615579,0.0008116666,-0.07637327,-0.0067005977,-0.02730049,0.032015357,-0.054396566,0.07646041,0.02081717,0.035460997,-0.060660724,-0.046562184,-0.032523073,0.043169696,-0.12486208,-0.07464636,0.018460507,0.065079264,-0.005380501,-0.028399918,-0.06729407,0.030814124,0.05150415,0.21620809,-0.02265894 +1.14.13.144,"Requires cytochrome P-450. A rice, Oryza sativa, enzyme involved in the phytoalexin momilactone biosynthesis. It also acts similarly on 9beta-stemod-13(17)-ene.",384,1.0,-0.08914666,-0.05367586,-0.052051224,0.0052572764,0.047040023,0.09379909,-0.11295953,0.023958093,-0.0054028234,0.006070962,0.123568706,-0.03622626,-0.042534877,0.067413926,-0.018313155,0.038086407,-0.058033988,0.019567855,-0.08151426,-0.063124664,0.057108995,0.093229055,0.05107928,-0.0063199215,0.0122900745,-0.04200692,0.03313118,0.057382677,0.033107482,-0.03810438,-0.068862185,-0.01013982,0.0078862365,-0.00037912434,0.0051292595,0.07501248,-0.043937366,-0.1092328,0.04167206,-0.060301922,0.04704722,-0.060780156,0.002572037,-0.013123773,-0.005586039,-0.07971095,0.009787455,-0.06912859,0.04176339,-0.08694671,-0.047757745,-0.03359327,0.00028475584,0.03206198,-0.015925108,-0.017292721,0.029297177,0.015546087,-0.02484808,0.03221574,-0.050203405,0.049807314,-0.0369059,0.008614513,-0.015470427,0.013521427,-0.037526097,-0.023832262,-0.015294383,-0.035895336,0.040589415,-0.07359831,0.015388353,0.086396344,-0.028045861,0.031296737,0.014844337,0.010650332,-0.015899288,-0.0463873,-0.008679865,0.025868779,0.03154166,0.13797592,0.04865144,0.016278978,-0.07256863,0.07183772,0.008048566,-0.038828634,0.03461863,-0.01812682,-0.015524868,0.03765229,-0.0015635389,0.08440898,-0.011257655,-0.073548675,-0.03921898,-0.02719506,0.00564667,0.06488609,-0.11268022,0.0122853285,0.028004438,0.020063812,-0.020197213,0.016334832,-0.013942969,-0.0027803653,0.004878772,-0.03501031,-0.014199775,0.0143564055,-0.052223675,-0.023628313,0.0043960093,-0.047118105,-0.04706766,-0.063655555,-0.020187756,-0.04856935,-0.045924746,-0.0042251404,-0.045680184,0.008189808,-0.087678716,3.31458e-33,0.11414088,0.068025514,-0.025633156,-0.008794568,0.043378506,-0.027711177,-0.027508693,-0.022174131,0.00015597758,-0.04719786,-0.15415743,-0.07634717,-0.07809008,-0.036000207,0.011073264,-0.00026140225,-0.068384096,-0.03162279,0.0637305,0.01994685,0.0005594287,0.017947983,-0.06397397,-0.04912392,-0.01678513,0.026004286,0.034549747,-0.033579186,0.031564254,-0.018636927,-0.03234409,-0.04851747,-0.06839018,-0.063893095,-0.0017157249,-0.047636636,0.0074231066,-0.03114674,-0.055677176,0.029033052,-0.005952167,0.06344907,-0.011475464,-0.04272633,0.1323056,0.03244057,-0.056763995,0.1493912,0.021112105,0.06238301,0.052801423,0.0069249254,0.07411978,0.092964426,-0.024781074,0.0051244246,0.032661024,-0.025832575,-0.00735275,0.07262756,0.005273444,-0.063798465,0.043974865,0.12076508,0.03528259,0.03697091,-0.10116161,-0.03289253,-0.04918955,0.06352974,-0.055169247,-0.07047076,-0.0507864,-0.0037867029,-0.024140853,-0.029407531,-0.008869643,0.03125762,0.02587103,-0.032586463,0.045896493,-0.01743962,0.023621231,0.013390731,-0.022030644,0.04849888,-0.056508325,-0.007235459,0.03165971,-0.03072509,0.064663336,-0.04675636,0.044385955,-0.005101815,-0.050327666,-3.3800425e-33,0.047727834,0.0002831372,0.0668357,-0.052091368,0.006312761,-0.0702149,0.0024608325,-0.010079703,0.061776135,0.03589252,0.06440024,-0.03412268,0.07039186,-0.0669952,-0.04314087,0.081282526,-0.0008821513,0.13167454,-0.003056112,0.04234246,-0.04683439,0.09788855,-0.042122334,0.0013072517,0.03603198,0.04418614,0.010547019,0.08270932,-0.009339298,0.012992272,0.02523121,-0.0327123,-0.059509136,-0.008934939,0.0043054554,0.0552634,0.0035137518,-0.049639452,0.018881852,0.083322,0.039375555,0.068139285,0.02134078,0.07650769,-0.0394607,0.055260506,-0.08564351,0.04287518,-0.019887432,-0.06611744,-0.007878578,-0.02922067,0.027009295,0.032248057,-0.007089198,0.005706679,0.071228884,-0.0027755434,-0.048414953,-0.051798344,0.025315838,0.0039962223,-0.023359604,0.0117813265,-0.023574175,0.047855124,0.014939236,0.054606467,0.0026558524,0.058013964,-0.0020448847,-0.005939048,0.073433734,0.042959776,-0.051557604,0.037298225,-0.045808524,-0.004954098,0.094480515,0.036887202,0.011056181,-0.0015028332,-0.014634516,-0.08777173,0.023978865,-0.044574834,0.026241703,0.11570545,0.10263865,0.008269308,0.030929381,-0.010450066,0.017166227,0.049618486,0.07151336,-3.5155615e-08,0.08920674,-0.0990045,-0.0032875633,-0.049173128,-0.059014298,-0.075495124,0.027927527,0.012825112,0.08359774,-0.03442107,-0.052097935,0.061684087,-0.057581473,-0.0044698054,7.5149146e-05,-0.025043748,0.08928016,0.11195728,-0.020917607,-0.060792673,-0.09365704,-0.054164775,-0.01562033,0.025664229,0.026955895,-0.033787753,-0.030435272,0.03692041,0.07396733,0.026724862,0.011804821,0.0053783623,-0.008909722,-0.054799013,-0.055690628,0.099688746,0.016862119,-0.047210507,0.029234488,-0.045271024,-0.019695532,-0.0683526,-0.020100903,-0.008493016,0.011761735,-0.0035702102,-0.0055477372,0.04206653,0.031195875,0.024029551,0.00055269327,-0.07556613,0.05076917,-0.124436356,-0.10149291,0.013005911,0.01998382,0.027847882,-0.055710148,-0.059639074,0.025275156,0.046367917,0.20737217,-0.055710398 +1.14.13.145,"Requires cytochrome P450. A rice, Oryza sativa, enzyme involved in the biosynthesis of the antifungal phytocassanes.",384,1.0,-0.087425016,0.027513223,-0.060079314,0.033313558,-0.012594866,0.076003544,-0.10896975,-0.032585584,-0.017889062,-0.0054334034,0.12118249,0.000983327,-0.0458284,0.028843287,-0.038126357,0.02547436,-0.013261215,0.039613992,-0.09984396,-0.095946275,0.036213662,0.06707424,0.06428791,-0.01919519,-0.00010184061,-0.03389781,-0.013075353,0.059684876,0.029384643,-0.080665715,-0.036500324,0.035710834,0.01875864,-0.049383715,0.006971412,0.03553524,-0.016905332,-0.03549012,0.11396962,-0.035491835,0.019567098,-0.067609176,-0.029998997,0.018410863,0.0038172686,-0.08416659,-0.027889455,-0.030395305,0.056240294,-0.10796781,-0.071129456,0.055043068,-0.045248322,-0.008691813,-0.031785052,-0.028301034,0.030772427,-0.021345688,-0.056060713,0.023624545,-0.015091031,0.015357775,-0.052374057,0.044721022,-0.09206959,0.021535352,-0.059207544,-0.030696088,0.05607152,0.030687306,-0.035100233,-0.0876783,-9.621426e-05,0.06481915,-0.030647995,0.020547563,0.07843379,0.004713675,-0.019392082,-0.0086075375,0.031979218,-0.0072556287,0.025276314,0.103581965,0.03921787,-0.0050904043,-0.05203943,0.09566607,0.0094300825,-0.04415884,0.049490213,0.035186924,-0.0049746614,0.038428225,0.008479193,0.080626085,0.01242474,-0.040590342,-0.064413205,-0.02289748,0.019170074,-0.011503933,-0.052372396,-0.0037475973,0.014120433,0.004350875,-0.0094418535,-0.0071748043,0.026507143,-0.040208507,-0.0029535675,-0.037204675,-0.076148815,0.0053803525,-0.045133516,-0.027777057,0.024311822,-0.032438185,0.016618779,-0.09432983,0.010688876,-0.028154038,-0.0451583,0.009043868,-0.068703465,-0.024834713,-0.07235983,2.5303537e-33,0.053189375,0.10245755,-0.0047830585,0.010482236,0.034777537,-0.014515676,-0.008055856,-0.03761922,0.009258972,-0.051574852,-0.124674045,-0.049236238,-0.1021958,0.028308239,0.008561145,0.018842917,-0.04286878,-0.012692932,0.018293368,0.0013258101,0.0052985568,-0.0071240775,-0.10575634,-0.03538375,0.045041732,0.08808163,0.023587534,-0.029142022,0.04119789,-0.025401704,0.010983715,-0.041211,-0.04332229,-0.039370164,-0.0036512672,-0.03874048,0.00017442924,-0.017210422,-0.04825555,0.029046107,-0.03765863,0.079721354,-0.032636058,0.012435393,0.08071412,0.025647245,-0.08030665,0.13224028,-0.005086772,0.076578476,0.027286831,0.01639009,0.068612136,0.12851368,-0.01683497,-0.028127762,0.037494335,0.026462657,-0.024769139,0.03419542,-0.0027345463,0.0019573814,0.012004928,0.13088146,0.02807478,-0.0032916423,-0.07885108,-0.07344724,-0.033046734,0.07088897,-0.06601468,-0.060401753,-0.0072005712,0.010133001,0.0075654075,-0.078984916,-0.06268538,0.0057329927,-0.016563151,0.0736176,0.07537267,-0.059794817,0.019567333,0.010555789,-0.04181338,0.04248299,-0.049552906,0.020371735,0.065203235,0.012815797,0.07105386,-0.039242804,0.021967035,0.071028076,-0.028155288,-3.16183e-33,0.081747025,-0.023501204,0.044933327,0.011147534,-0.03304545,-0.002952778,0.0021016751,-0.07056983,0.049048726,0.025924297,0.040013243,-0.012979144,0.08167311,-0.050563384,-0.025353331,0.037746776,0.058440674,0.103228934,-0.023098666,0.09908918,-0.05026011,0.14553559,-0.016444625,-0.008315313,0.038694166,0.04567593,0.06859716,0.03464919,-0.056468103,-0.003938685,0.023249764,-0.044135116,-0.07409322,-0.095094316,0.030067855,0.04699188,0.03029787,-0.046292685,-0.007373458,0.07636622,0.009725895,0.06880187,-0.050571293,0.07827386,-0.029719649,0.0449822,-0.10054241,0.05915694,-0.020222414,-0.071948715,-8.556817e-05,0.050654046,-0.016974403,0.059132088,0.008611173,-0.022792066,0.02233586,0.0080646975,0.0032021778,-0.019963762,-0.027999232,-0.027791098,0.0006936487,0.0054589454,0.008750667,0.090732105,0.031929765,0.09105558,0.047578596,0.00050670165,0.0015034644,0.03350564,0.049962036,0.07398737,-0.07696103,0.10994319,-0.043220554,-0.03854218,0.05040418,0.062173225,0.040362354,-0.044924688,0.0022086431,-0.026567755,-0.047603436,-0.06706821,0.016971393,0.11213201,-0.0060503096,0.006616727,0.058887046,-0.055420697,-0.018460672,0.08755024,0.0645157,-2.976786e-08,0.04996174,-0.087894715,0.00061848573,-0.06766805,-0.06400554,-0.016312134,0.04261035,0.0015710747,0.09123647,-0.0033052096,-0.05421833,0.057601012,-0.029282307,0.07048911,-0.021656595,-0.024049917,0.07331942,0.0856385,0.013176174,-0.0044971243,-0.08838959,-0.049148474,-0.108952746,-0.02302765,0.05972705,-0.06121694,0.017951591,-0.011887031,0.092471436,-0.0063049155,-0.0035353436,-0.031913035,-0.004948989,0.02718995,-0.031479422,0.0867704,0.0070873005,-0.07324542,0.04446619,-0.022850914,-0.019527387,-0.066093475,-0.026707992,-0.0066747926,-0.037324924,-0.0531317,-0.0026236929,-0.00866464,-0.045728453,-0.02713641,-0.0034569236,-0.02119485,0.05045398,-0.10496042,-0.09222101,0.0049777273,0.06904605,0.029058857,-0.07315283,-0.056436364,-0.003319082,0.020234823,0.14204761,-0.04147108 +1.14.13.146,"Requires cytochrome P450. From the yew Taxus cuspidata. Also acts on taxa-4(20),11-dien-5alpha-yl acetate.",384,1.0,-0.07148707,-0.0019466926,-0.053462073,-0.08421466,0.024218572,0.024930025,0.02819386,-0.02559733,-0.049484953,-0.017112657,0.08326187,-0.014235644,-0.10295322,0.039783113,-0.018469486,0.018130513,-0.015226549,-0.061444685,-0.016562156,-0.013501995,0.07970659,0.0032610574,0.0895004,-0.02346897,0.00010437365,-0.018597275,-0.027072351,0.03212769,0.025253244,-0.114560336,0.02457521,0.062154453,-0.063581996,0.0020316872,0.023939252,-0.010472679,-0.019419635,-0.0053624134,0.02678621,0.012134762,0.05536392,-0.028940571,-0.046611648,0.0435784,0.012838535,-0.06666323,0.02542357,-0.0017324076,0.047879126,-0.011370247,-0.0069014775,-0.032132793,-0.030233841,0.04534947,-0.002596287,-0.066305384,-0.08162337,-0.033402137,-0.031437557,-0.038443435,-0.051477708,-0.013662733,-0.0057156086,0.011865318,-0.048441928,0.02836636,-0.02553598,-0.09065263,-0.031826694,-0.029615842,-0.0013333795,-0.08219739,-0.012079245,0.05139851,-0.15901177,0.06457026,0.027915861,-0.015860261,0.047291435,-0.056244653,-0.052083943,0.075067095,0.02371363,0.12447275,0.16555573,-0.027434379,-0.072826415,0.035510283,-0.052569073,0.033806212,0.02285464,0.01751092,-0.01732589,0.016789315,-0.054324914,0.051384438,0.07541556,-0.04879508,-0.021024127,0.014206099,0.03712186,0.004187916,0.009569502,-0.014410668,-0.14589913,0.04853885,-0.006242042,0.0076518776,0.019466188,-0.08498601,-0.03563715,-0.009818606,-0.058550116,0.010907722,-0.0078614345,0.040514104,0.003834094,-0.059210625,0.038275264,-0.1017732,-0.075421505,-0.017216185,-0.010352804,-0.006536052,-0.048660014,0.05139562,-0.027063694,2.7909773e-33,0.08024403,0.05483557,-0.02530103,0.039854333,0.044404656,0.061539374,-0.05934442,-0.018285593,-0.06952987,-0.050953276,-0.0829779,-0.03370491,-0.02450306,-0.024398025,-0.021195859,0.0758018,-0.04469848,0.031630557,0.06096438,-0.055143572,0.004400329,-0.01908227,-0.023274004,-0.075069256,-0.043183643,0.10918166,-0.028654862,-0.0020908986,0.084449306,0.049477465,0.017253706,-0.027839452,0.015845984,-0.029630378,-0.016448341,0.07877901,-0.038598534,-0.004230198,-0.042465843,-0.003074376,0.062674634,0.041392244,0.032884907,-0.03670789,0.054733116,-0.05396876,-0.04553893,0.11534583,0.00633548,0.0828093,-0.0004210993,-0.048062027,0.040891048,-0.013363344,-0.02880541,0.036730014,0.027820587,0.024832197,0.0014589635,0.032071196,0.07717067,0.051011246,-0.07307846,0.06633043,0.036714036,0.077872396,-0.042234175,-0.038682014,-0.07552714,0.08069361,-0.048661113,-0.023866666,0.057293687,0.03445116,0.12513205,-0.021974584,0.014447471,0.021459196,0.016209843,0.076197654,-0.016547615,-0.004265086,-0.028322665,-0.007094511,-0.005564636,0.0068104374,0.055260044,0.04260722,0.010652235,0.06535903,0.09617059,-0.10271132,0.010904868,0.0104522295,-0.057002585,-3.0622138e-33,-0.006112248,-0.0729338,0.03280289,-0.05026352,-0.046413347,0.03585553,0.08429098,-0.110598706,0.050646227,0.007767379,0.116773844,-0.016534757,0.0086086,-0.0027756589,0.010151679,-0.060526144,-0.029732034,0.04591921,-0.01774909,-0.010942198,0.006691204,0.11097572,0.0029899213,0.10562806,0.014752832,0.042062245,-0.001582177,0.042641163,0.009802919,-0.009385805,-0.06889263,0.04106511,-0.08976487,-0.09379914,-0.031166753,-0.021919675,-0.009401993,-0.018965729,-0.044889804,0.039286863,-0.016042018,0.05236374,-0.001298496,0.103638835,-0.014767352,0.031614717,-0.102154344,0.038192227,-0.04906109,0.06430933,0.061936837,0.05436304,-0.03486551,0.029029105,0.0120633,0.053183835,-0.04807188,0.008805218,-0.037120774,-0.021430966,-0.0510403,-0.02629497,-0.022491526,0.02107471,0.051654574,0.029907282,-0.020717911,0.11077345,0.093707494,-0.010490628,-0.039697044,0.0010900443,0.06350707,-0.02189583,-0.011226957,-0.011153991,-0.020987052,0.01626808,0.08693792,-0.010028777,0.030043967,-0.03167146,-0.035602473,-0.04720461,0.029220937,-0.071757115,-0.029888686,0.07811405,0.07838457,-0.0021106573,-0.0074677654,0.011260478,-0.046984978,0.08880419,0.013196525,-3.2543852e-08,-0.018753985,0.02795613,0.078006305,-0.013540846,0.00034805373,-0.0028342092,0.029050196,0.0032957713,0.049982797,-0.07213404,0.08290805,0.11864982,-0.00061131176,-0.019658849,-0.04048018,-0.0007716232,0.023999535,0.052882597,0.0038598308,-0.039601527,-0.07546854,-0.03517584,-0.04593964,0.0934472,0.014007817,-0.065835945,0.05387673,0.046161823,0.057010457,-0.008015693,0.024371602,0.0036372873,-0.03563618,-0.038221516,-0.06393287,0.05273032,0.010427712,-0.017590232,0.008426534,-0.005129683,-0.025689723,-0.0367441,-0.069908194,-0.02170791,-0.037523985,-0.028049003,-0.029286355,0.016914485,-0.05939147,-0.012219292,-0.029598782,-0.028514452,0.009280863,-0.06529347,-0.14881356,-0.018987732,0.053879835,-0.06095696,-0.06853855,-0.09570802,0.09299675,-0.0047760303,0.16200058,0.025251424 +1.14.13.147,Requires cytochrome P-450. From the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis. ,384,1.0,-0.041529708,-0.0008007838,-0.08611456,-0.0678619,0.028270174,0.016635554,-0.01404352,-0.0074178926,-0.014126544,0.013874687,0.078888856,-0.035286035,-0.08699784,0.025560316,0.022467667,0.014247857,-0.04855691,-0.034758065,-0.023324126,-0.034802962,0.08777956,0.03792991,0.06019052,-0.006148666,-0.020165637,-0.04642347,-0.05915186,0.0418927,0.04592402,-0.1006743,-0.025680717,0.065753646,-0.049237095,-0.0023175522,0.018918883,0.047996607,-0.045229647,-0.008239558,0.041414537,-0.015092242,0.06383239,-0.049894746,-0.068307884,0.037965056,-0.042801347,-0.06392272,0.0022680475,-0.0069158473,0.014825194,-0.029485226,-0.047853716,-0.041262392,-0.0038982371,0.025815155,0.01476524,-0.025916409,-0.006955074,-0.02977212,-0.01646482,-0.062092356,-0.07085585,-0.0006326077,-0.027073491,0.0021739977,-0.03623894,0.013709326,-0.016536891,-0.08747157,-0.025267081,-0.036574136,-0.04238881,-0.0871323,-0.0118085295,0.068126515,-0.13780852,0.11060767,0.034940004,0.021000605,0.0012505254,-0.0824682,-0.018866975,0.048138008,-0.005993729,0.12883586,0.09728817,-0.027819961,-0.03746817,0.044641323,0.0040113525,0.04671957,0.0464842,0.002530738,0.0060770516,0.02049657,-0.07618404,0.065789185,0.055752818,-0.060980536,-0.03249975,-0.02687016,0.027443767,0.051512823,0.012454635,-0.06949435,-0.13397183,0.037659936,-0.08522062,0.026380645,0.011913989,-0.053110663,-0.0057149436,-0.024947291,-0.020010827,0.01914074,-0.016535925,0.058604553,0.020114597,-0.06480104,0.0046755853,-0.045082618,-0.04722352,-0.040124215,-0.007181448,-0.0037858875,-0.046023317,0.009357608,0.0033863857,2.7433981e-33,0.089326225,0.06098252,-0.028000776,-0.014665805,0.069850124,0.053291183,-0.066907436,-0.0065419693,-0.090860106,-0.06409643,-0.12721851,-0.09907827,-0.03925531,-0.057448562,-0.013324254,0.08606743,-0.041794524,-0.0030941716,0.050848037,-0.007104092,-0.0050079473,0.011043643,-0.029122224,-0.093758486,-0.04065001,0.13512985,-0.031075627,-0.018432263,0.042976417,0.027483303,0.04103361,-0.036120962,0.006775456,0.012190121,0.012527322,0.06215623,-0.004940836,-0.050927896,-0.04109153,0.0052376813,0.035289608,0.05171347,0.0776678,-0.02751672,0.07333166,-0.069974355,-0.04833463,0.10825967,0.015319125,0.07942745,0.025749361,0.013796322,0.05516849,0.004246388,-0.05060869,0.011137853,0.037918072,0.033997003,0.004878237,0.0804275,0.07410844,0.014748999,-0.038883395,0.046372212,0.029345235,0.07462463,-0.113784745,-0.029814765,-0.06332559,0.09139104,-0.063299306,-0.050973248,0.030829512,-0.0007124127,0.101606965,-0.016841896,0.015367737,0.027630916,0.034872063,0.084328,-0.019385625,0.0045052655,-0.050307382,-0.0070399824,-0.008044431,-0.02482874,0.029036997,0.07937816,-0.0064061675,0.02057107,0.07320395,-0.06471359,0.0040384685,0.021088388,-0.009980066,-3.7533766e-33,0.031861927,-0.07959582,0.07048537,-0.035003994,-0.02078012,0.020548744,0.026957255,-0.14721477,-0.003999123,0.019846993,0.09553524,-0.017720973,0.0036164671,-0.00010599881,-0.020356854,-0.03394172,0.007658876,0.10177231,-0.026086256,0.01026808,0.04396164,0.10865736,0.007050742,0.07630062,0.017285995,0.0109857535,0.004294123,0.03755544,0.009229695,-0.0132855475,-0.033590365,0.05683255,-0.07900423,-0.092606515,-0.020271152,-0.018878551,-0.03815165,-0.010891048,0.031311482,0.079008296,-0.026697185,0.0707582,-0.0063744015,0.03820953,0.018926451,0.03528676,-0.09909369,-0.008470507,-0.035995763,0.016112229,0.074484445,0.07208528,-0.011798439,0.04249546,0.009110135,0.04382412,-0.017848724,0.008150117,-0.011450076,-0.067550875,-0.051752757,-0.009236984,-0.01348524,0.0061518997,0.028857758,0.04460649,-0.017407337,0.118562154,0.08334094,-0.03403657,-0.045166876,0.018936405,0.056785446,0.0032774166,-0.025630126,0.04598067,-0.03445524,-0.03379481,0.09086198,-0.022697221,-0.012786909,0.0028152529,-0.0418187,-0.050767496,0.015762605,-0.08030822,-0.015374407,0.074422605,0.059157066,-0.01785249,0.0081317155,0.00030856373,0.0061530764,0.095243074,0.07036176,-2.8842136e-08,-0.044006385,-0.01183222,0.0253531,-0.00087421323,0.032275353,0.0012694737,0.01923519,-0.00957264,0.028241986,-0.064879104,0.051692113,0.083376355,0.025889304,0.019906348,0.04116457,0.02258495,0.041886136,0.010991774,0.006336256,-0.004165594,-0.06652831,-0.061801873,-0.06687894,0.11479775,0.010465638,-0.07449673,0.0389435,0.02125748,0.044092067,0.0039629517,0.031566832,0.014840474,-0.052484177,-0.033667788,-0.026706873,0.06298577,-0.031089641,-0.047629982,-0.00627145,0.008422681,-0.004557257,-0.10396646,-0.055180997,-0.013636399,-0.036857706,-0.0058897664,-0.022782458,0.039476022,-0.07864643,-0.0058695585,0.01907868,-0.028645905,0.025439128,-0.108744614,-0.1305063,-0.015632262,0.064403445,-0.070566565,-0.07077019,-0.10646336,0.09334045,-0.020694071,0.18254447,-0.00604818 +1.14.13.148,"A flavoprotein. The bacterial enzyme enables bacteria to use trimethylamine as the sole source of carbon and energy [1,4]. The mammalian enzyme is involved in detoxification of trimethylamine. Mutations in the human enzyme cause the inheritable disease known as trimethylaminuria (fish odor syndrome) [2,3].",384,1.0,-0.055358432,0.0038540347,-0.011850419,0.087910466,0.07200711,0.011117008,0.01026739,0.058033228,0.02639664,-0.015144077,-0.01614216,-0.07107129,-0.059250318,0.043620065,-0.034012504,0.04314419,-0.07339931,0.024610735,0.0016076779,0.0037238025,0.004143143,0.08238803,-0.027400939,-0.025751108,0.015912144,-0.0056435224,0.049094208,-0.046735886,-0.020158727,-0.026814213,0.07070078,-0.022523107,0.10678026,-0.065372385,0.028801804,0.081646,-0.02794171,-0.070140384,0.06717257,0.028314976,-0.039636184,-0.026077533,0.046654675,-0.005742121,-0.043833904,-0.029689975,0.01634602,0.052746683,0.046564348,0.003416844,-0.059602883,0.0058403756,-0.053433985,0.050389983,0.040074404,-0.044555504,-0.0495052,-0.057637595,-0.06289957,-0.06213831,-0.022263106,-0.044663124,0.05254448,-0.04390099,0.055838265,-0.102509454,0.055411305,-0.032577656,0.019541308,-0.054564063,-0.01887658,-0.046430226,-0.050928403,0.033725493,-0.032450225,0.061238773,-0.007963424,-0.055616073,0.06813304,0.0028331794,0.019700807,-0.063047074,0.01835773,0.11747413,0.04791711,0.019955596,-0.049260523,-0.01833234,-0.028303504,0.04521491,-0.01801797,-0.00227382,0.045087796,-0.040636826,-0.064511076,-0.05094009,0.060661506,0.003100997,-0.0139223095,-0.00907077,-0.07741032,-0.012670333,-0.051655557,-0.021189025,-0.008561611,0.004708744,0.017141066,0.0860983,0.0803916,-0.04826293,0.009262311,0.029432852,0.0028986214,0.02374405,-0.0019827287,0.09754014,0.083382905,-0.100196406,-0.10071606,0.054614615,-0.06565675,-0.0024601992,0.05078738,0.05292201,-0.039075926,-0.0067852656,-0.053065717,9.29184e-34,0.0032355243,0.014224041,0.0006234754,-0.038863413,0.057883345,-0.017709842,-0.04255656,-0.027589567,0.049198564,-0.10203804,-0.08140163,-0.039315768,0.060224064,0.011354015,0.02792598,-0.025799165,-0.03227714,-0.0009062491,0.069087535,-0.06794841,0.051268354,0.01185915,0.047102302,0.013888316,0.036792424,-0.04306474,-0.038360603,0.017760364,0.012768985,0.015943496,0.00392999,-0.04475484,-0.07603566,-0.022999004,0.044036735,0.013831843,-0.016135192,-0.0068215504,-0.12081751,0.04233668,-0.02636475,0.030668767,-0.033416655,-0.06430874,0.01622598,-0.030952692,-0.07940495,0.09434089,-0.01535144,0.06519049,0.031285755,-0.030941943,0.11879305,0.02076619,-0.08731722,-0.037069507,0.009564893,-0.11674008,-0.017179448,-0.00779992,-0.019698972,0.1009032,-0.034032714,0.025216188,-0.057390705,-0.040776756,0.014991929,-0.04722498,0.031989776,0.11530866,-0.04466892,-0.016904788,-0.010330565,-0.039858077,-0.016022597,-0.039466426,-0.14328833,-0.014996983,0.0258665,-0.034017053,-0.05088476,-0.06251118,0.045075107,-0.015245228,-0.047507893,-0.003228934,0.0027485115,-0.008583207,0.008346441,-0.011386717,0.10271551,-0.094315164,-0.035643745,0.017993597,0.014836112,-2.320679e-33,0.040826138,-0.09985573,0.0067800437,-0.017284995,-0.0032143735,0.027290707,0.01658569,-0.012232495,-0.034977663,-0.071306236,0.011760367,0.0011968092,-0.012941328,0.03323116,0.049931277,0.036112566,0.0039494354,0.044887815,0.0019228031,-0.06704523,-0.024839144,-0.00928363,-0.007829979,0.027208038,0.0083162105,0.050557543,-0.054212037,-0.039786424,0.05811984,0.012164483,-0.049492486,0.10120623,-0.038700443,-0.07530504,0.053600002,0.04092128,-0.039872166,0.077093706,0.010915355,-0.018477233,0.04426621,0.0024015396,0.021253712,0.09316265,0.017907105,0.10868399,-0.042951923,-0.00497876,-0.024585743,0.0011462889,0.13936466,0.036451966,0.029580845,0.04001697,0.037691295,0.016925212,0.041948922,0.042571478,-0.0038525301,-0.005830095,-0.057549067,-0.080624476,0.01690965,0.0038285726,0.023337297,0.038031653,0.016559808,0.09185636,0.049760457,-0.0770322,0.013299367,0.021260504,0.07455151,0.061661277,-0.08020625,-0.004393503,-0.08324616,-0.022873726,0.039889358,-0.007279064,-0.028063469,-0.017810632,0.04704137,-0.06760386,-0.049471248,-0.09832494,-0.0114026945,0.07713923,0.01850715,0.025452679,-0.056103013,-0.0354178,-0.06918748,-0.043690696,0.022901908,-3.9094754e-08,-0.045989454,-0.03175969,0.02855589,0.038160447,0.00067753653,0.052995242,0.04337378,0.09156186,0.097397044,-0.04130325,-0.011933082,0.1526178,0.041387036,0.01245403,0.052440964,-0.017157517,-0.028782938,-0.03244787,-0.01400616,-0.08506301,-0.09321098,-0.03972907,-0.083299,0.05386844,0.038445223,-0.09125606,-0.01760428,0.07242114,0.059199356,-0.06499524,0.012591191,0.06158815,0.0026208484,0.0069677588,-0.08915865,-0.01825218,0.037094783,-0.10671541,-0.00544489,0.05765828,-0.007825941,0.045167137,-0.13461727,-0.050649833,0.016439045,-0.005625902,0.051012415,0.066300794,-0.025191346,-0.015146013,0.02817134,0.0038564613,-0.014108677,0.035706513,-0.07006092,0.007818842,-0.005577077,-0.023789894,0.0018756189,-0.07544353,0.11462629,0.04932279,0.1731215,0.0030653633 +1.14.13.149,Part of the aerobic pathway of phenylacetate catabolism in Escherichia coli and Pseudomonas putida.,384,1.0,0.01880879,-0.094202496,-0.054510977,0.019637562,-0.0066016424,0.102600776,-0.056830004,-0.002472557,0.036340907,-0.019379621,0.029048882,-0.019958789,0.005311919,0.08681367,-0.045443427,-0.010597405,-0.09995592,0.05428145,-0.05987151,-0.005935775,0.11704059,0.071324,0.009758924,0.05790173,0.0030641023,-0.0038492305,0.07027646,-0.030077608,-0.030035844,0.02169203,-0.0065524406,-0.026884135,0.061506405,-0.053376116,0.062206294,0.039238468,0.045978025,-0.056241933,0.06797271,-0.0033427388,-0.031698734,-0.022392055,0.008939624,-0.090666294,-0.02181226,0.05745062,0.071305655,-0.019178333,0.055748682,-0.06640569,-0.028492006,-0.03173651,0.040940143,-0.02854801,0.014175527,0.049240466,0.01706625,-0.06340817,-0.0523464,-0.0014602176,-0.0056100884,-0.018113725,0.017223101,0.047044843,-0.082241476,-0.054527782,0.018633576,0.041937165,0.03568644,-0.023005381,-0.08386903,-0.047601987,0.0554373,-0.00804375,-0.046156257,0.0022221515,0.08447305,-0.04026181,-0.008961988,-0.029794725,0.04075636,-0.092421345,-0.032583762,0.03909122,0.008160743,-0.04177306,0.03995808,-0.00012903663,0.062224492,0.046772752,-0.039883018,0.003179552,0.011880811,-0.07961794,-0.048594657,-0.0009201281,0.0062022475,0.04608361,0.049797203,-0.042851027,-0.027476013,0.044806015,0.069758356,0.005666012,-0.010801266,-0.06467199,0.07592709,0.11754759,0.028641278,0.01175527,0.086073995,0.018573992,0.03522813,0.0067063007,0.051008973,0.074581586,0.06834675,-0.112316884,-0.079207085,-0.049124386,-0.09136603,-0.09236348,0.06411062,0.085009426,-0.07314456,-0.046224143,-0.045499593,8.283581e-34,0.064597465,-0.007866217,0.020523673,-0.059410717,0.04215923,-0.016718619,-0.09411738,-0.029376928,0.07642891,-0.09047364,-0.062839665,-0.07526541,0.040093984,0.03174872,0.007365727,-0.043949425,-0.06604805,-0.010334929,0.07623659,0.018191474,0.04429501,0.028174743,0.02050979,0.014252429,0.067254595,-0.016029065,0.003033613,-0.03451474,-0.05157754,-0.029834718,0.046168428,-0.07042221,-0.076764666,0.005803315,0.011684013,-0.010303638,-0.053021092,0.04580671,0.013169754,0.06234498,0.028107183,0.03140038,-0.018703578,-0.024601437,0.06145403,0.0012241577,-0.013958964,0.1548191,-0.005200258,0.1309465,0.04095039,-0.023634804,0.09409755,-0.008955749,-0.06953054,-0.004633556,0.0056297607,-0.04751193,0.013224968,0.02356681,0.032099795,0.096856855,-0.01743352,0.09015951,0.03066291,0.010564452,-0.04001816,0.0022546106,0.073744096,0.065296404,-0.102754176,-0.022570502,-0.008457638,0.037189715,0.06485392,-0.100999646,-0.105179824,0.007763589,-0.046920665,0.03871537,0.08178024,-0.04999821,-0.07950723,-0.006230778,-0.0397355,0.04884331,-0.013694699,-0.008128719,-0.00032056315,0.040355716,0.05086587,-0.083256945,0.03106202,0.06421393,0.021888368,-2.1948924e-33,0.11309363,-0.08686984,0.031859215,-0.034522872,-0.015971119,0.05768702,-0.00031782725,0.0776848,-0.064202085,-0.07554638,0.010873118,0.03018864,0.032203574,0.018493932,-0.0046495646,0.0023689482,-0.015211209,0.034541503,-0.0020076276,0.014564214,0.005100996,-0.027191693,-0.05700865,0.043166935,0.075313605,0.07334728,-0.0047137747,0.10291094,-0.009861502,0.001148666,0.02053473,0.028179564,-0.042083826,-0.04485016,-0.04138188,0.06419419,-0.08147767,0.002653879,0.03338695,-0.019460777,0.0056776316,0.038182255,-0.06746604,0.04999084,-0.050882503,0.057765145,-0.08731782,-0.051004924,-0.014962546,-0.13485932,-0.028618744,-0.0023047603,-0.02495109,-0.010324986,0.05351229,0.008454455,-0.015091421,0.015984135,-0.08816135,-0.06637138,-0.053106394,-0.072272934,0.017863875,-0.027872311,-0.014953204,-0.027229678,-0.009264427,0.0802307,-0.0015784085,-0.012245572,-0.0155729465,0.019918116,0.014443879,0.07247663,-0.053476427,-0.005754484,-0.04876653,-0.06444007,0.007582241,0.044082515,-0.049463484,-0.020328011,-0.011406168,-0.10183971,0.030141046,-0.031919863,-0.02711601,0.041548397,-0.02507862,-0.009389282,0.048085067,-0.018431684,0.032347575,-0.013062743,0.048891835,-2.562269e-08,0.04741708,-0.084780596,0.081557326,0.029001255,-0.025509752,0.044349235,0.021868002,-0.00028518174,0.002285104,-0.09341198,0.011130516,0.027165517,-0.022200963,0.03262323,-0.002852802,0.038488522,-0.12754291,-0.060607865,0.0009586963,-0.006564436,-0.117671326,-0.063165076,-0.14286081,0.08461239,0.053791948,-0.027017009,0.02045438,0.037006445,-0.0011552264,-0.06622089,0.024135977,-0.04849693,-0.00063138705,-0.011704385,-0.021912409,-0.0033802341,0.03021066,-0.044207048,-0.025394602,-0.015648862,0.0127619095,-0.010777433,-0.05679074,0.007832408,0.0638998,0.08486809,-0.035533085,0.028898135,-0.018898109,-0.06805951,0.058678158,-0.0025461318,0.013184765,0.06434118,-0.10257804,0.049850404,-0.008955035,-0.0487987,-0.042702273,0.030413773,0.0137196295,0.030817527,0.10490556,-0.026567472 +1.14.20.2,"The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).",384,0.99999994,-0.07951815,0.03794919,-0.084091626,0.0019074348,0.04170515,0.10363894,-0.036943838,0.02428693,0.052127223,0.0020435124,0.051456075,0.008920901,-0.040170103,-0.023733918,-0.09905698,0.12627433,-0.04124019,0.02268124,-0.072734796,-0.034914937,-2.9513074e-05,0.04327888,0.039197426,-0.0026383253,-0.0029871925,-0.028907593,-0.026244504,0.019713629,0.009356962,-0.066944905,0.022404846,-0.008133431,0.116295874,-0.037823893,0.015628938,0.05705405,-0.0474806,-0.0668978,0.051413726,0.03407228,0.014689178,-0.020569682,-0.09973508,-0.033713542,-0.054815467,0.0011716766,0.071881555,0.054692566,-0.003039277,-0.021226583,-0.020860458,-0.035670336,-0.011858547,-0.01719541,-0.06803745,0.018392676,-0.010203586,0.026242794,-0.11926039,-0.01409343,0.018609758,0.019154768,-0.06836808,0.047443055,-0.030974725,-0.039364237,0.016138872,-0.025451051,0.04297558,-0.092254356,-0.0394435,-0.097433716,-0.027745074,0.027216693,-0.0697292,0.04585222,-0.050718665,0.019947555,0.013145087,-0.036517385,0.063245855,-0.00040906147,-0.0016749437,0.069891445,0.0546527,0.04016804,-0.040780813,0.09490698,0.06515592,0.03607216,0.009353038,-0.12637357,-0.022018671,0.06610496,-0.06827765,0.08377349,0.053069044,-0.041039217,0.01823494,-0.03935296,0.024968898,-0.01636002,0.04652074,-0.071334794,-0.047877774,0.028126113,-0.036014654,-0.014485554,0.010305182,-0.07217688,-0.053374875,0.037110835,-0.015333581,0.009291231,-0.022469742,0.03362953,0.043439277,-0.057853103,-0.019912438,0.031913854,-0.015916679,-0.0044070357,0.01938846,0.07481221,-0.018069206,0.07699661,-0.14188646,-3.6478062e-34,0.075246416,0.04360638,-0.04146581,-0.021222895,-0.025553256,0.025671741,-0.07511481,-0.031302486,-0.06765962,-0.028945144,-0.09856069,-0.09558228,0.06453224,-0.059147377,-0.020455454,0.023750858,-0.033533514,-0.011877572,0.05635669,0.00055035343,-0.02782024,0.025154572,-0.13191229,0.029410176,0.0023774563,0.11969612,0.025827862,-0.012041261,0.0062383986,0.0059810816,-0.01898563,-0.08363607,-0.08716461,-0.010190721,0.075776726,0.03373074,-0.0940075,-0.051199276,-0.011518114,0.047598515,-0.0454807,-0.0038923244,0.006619037,0.020440714,0.06463223,-0.013139532,-0.124729514,0.097682156,0.08279601,0.073915,0.03780297,-0.048018936,0.1264829,0.027515167,-0.085113354,0.028782435,0.010962413,0.044988073,0.017707951,0.029147023,-0.023147058,0.010684438,-0.059066948,0.017863175,0.01713635,-0.03322027,-0.06000081,0.021515941,-0.036965817,0.120355316,-0.008304387,-0.04409594,4.5865087e-05,0.0750948,0.04676114,-0.05107917,0.007339049,0.0050996603,0.059427686,0.05964141,-0.005899102,-0.034840494,0.016381368,-0.058861915,-0.06480882,0.0072745048,-0.035857987,0.012694206,-0.004079732,0.020984901,0.06232483,-0.050011136,-0.0057337508,-0.005683712,0.019470459,-2.3035171e-33,0.08764444,-0.036832545,0.059084434,-0.06241103,0.007252,0.07123692,-0.051451452,-0.016084561,0.01583457,0.06427599,-0.02428523,-0.009802892,0.018385118,-0.016944887,0.03760821,-0.021938873,0.016012598,0.06743936,0.02190543,0.011729834,-0.10001894,0.022270542,-0.017932365,0.0037292505,0.012080716,-0.017408386,-0.0330736,0.031188246,0.01696058,0.070785016,-0.0010242133,-0.025254918,-0.054251466,-0.0015746854,0.045985464,0.062134374,-0.04748169,0.042932272,0.029011259,-0.009237769,-0.05660206,-0.037394844,0.08766138,0.07536607,0.07547213,0.07297517,-0.15101925,-0.0066933604,-0.07717865,-0.024320923,0.008423234,0.09425285,0.09062684,0.06031868,0.049603384,0.004513137,0.02670176,-0.029048417,-0.049835365,-0.05771488,0.0020557814,-0.029820649,-0.03274834,0.06591754,-0.03259984,0.051941577,-0.019151034,0.078397356,-0.010045339,-0.007810529,-0.015223678,0.010227511,-0.013118688,0.039601464,-0.06744874,0.03859496,-0.037657876,-0.041196898,0.005308785,-0.020836385,0.03315671,0.018945778,0.017852902,-0.05929494,-0.041360464,-0.064664066,0.010932198,0.106546946,0.045392513,0.008273244,-0.0010871212,0.04033884,-0.073629014,0.026239647,0.06302664,-3.0865706e-08,-0.024828674,-0.0776967,0.026627388,-0.054264598,0.007432932,-0.057047594,-0.016113903,0.010902588,0.043029748,-0.0054509966,-0.034847815,0.061901845,-0.0032512182,0.030359646,0.060320053,-0.012578531,0.0067267,0.029516371,-0.020216186,0.08203007,-0.05516833,0.04091022,-0.07896779,0.016055392,0.023146715,-0.041687317,0.02061663,-0.020868817,0.03359945,0.015398307,0.045097154,0.021388216,-0.02062766,-0.0087007275,-0.10807672,0.06908199,0.049757183,-0.10409432,-0.02254855,-0.00044968724,0.0058974666,-0.082362846,0.01461803,-0.012491267,0.012193158,-0.009130013,-0.015436208,-0.032945964,0.013772056,0.021897675,0.0037879103,-0.0048791072,-0.01423644,-0.04920709,-0.11734913,-0.0076917745,0.044385575,-0.071038306,0.011642314,-0.07524142,-0.058148105,0.044295,0.22163224,0.008954454 +2.1.1.239,"The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus. It can also act on other monoglycosylated macrolactones, including L-rhamnosyl-erythronolide B and L-mycarosyl-erythronolide B. ",384,0.99999994,-0.051085204,-0.017267674,-0.0877375,-0.02335034,0.0063923625,0.03257717,-0.08981219,0.10168015,0.08034334,-0.043287553,-0.033616357,0.04021544,0.06001692,-0.0029438375,0.0064074206,0.04524196,-0.058660276,0.034648914,0.0019006315,-0.015853064,0.080311134,0.04193488,0.060117476,0.002281426,0.03646505,-0.052070085,0.034839906,0.04926058,-0.0182366,-0.053381864,0.082601465,-0.04927299,0.06112936,-0.038740117,0.06901756,0.038677968,-0.06774184,-0.057516586,0.13692755,-0.02681967,-0.04541088,-0.042782947,0.039474048,0.016481766,-0.01878625,-0.042869892,-0.044422124,0.0575343,0.008363318,0.003895541,-0.054551587,-0.050825458,-0.0463679,0.07082951,0.06536771,0.0837041,-0.07217636,-0.052088533,-0.008536463,-0.020917768,0.06254632,-0.0028610965,-0.012812351,0.029627513,-0.15242992,-0.017673302,0.034167103,-0.05182989,0.016121909,0.024277609,-0.06597133,-0.05118823,0.003586913,0.06528689,0.04437455,-0.03256475,-0.0132125635,0.012521437,-0.05629224,-0.037578,0.035041157,-0.0032151681,0.007918356,0.0508335,-0.00083562685,-0.01839591,0.05449641,0.027762536,0.08930799,0.02561434,0.05198898,-0.03975258,-0.04173637,-0.021408629,-0.05750399,-0.03538196,-0.046162475,-0.0005303714,0.0713978,-0.00073185976,0.0033711076,0.008511758,0.018118229,-0.026382852,0.0042087515,0.048146043,0.016639449,0.035387307,0.0198385,-0.056297336,0.04120521,-0.051346805,0.036090553,-0.01062882,-0.07942542,0.02718738,0.09924908,-0.0915523,-0.094062164,-0.0035624143,0.012990556,0.02769913,-0.0021707008,0.011581633,-0.018253492,0.009710855,-0.081189945,3.1390052e-33,0.022404822,-0.005533791,-0.06471524,-0.061018325,0.09849725,0.00968788,-0.037674457,-0.040832948,-0.043839507,-0.0023003668,-0.09382598,-0.0536875,0.019233277,0.108812034,-0.040300075,0.0050324854,0.028310461,0.03943019,0.019389171,0.017788416,0.030649114,0.025411036,-0.02890901,0.031760782,0.0010791059,0.12874557,-0.020783566,0.031443033,0.10156391,-0.0061782906,-0.014287986,-0.07575077,-0.07687689,-0.0034475161,0.09276176,-0.002349659,-0.09027274,-0.06444356,0.08451137,0.009689599,-0.020122996,0.005593457,-0.07340441,0.0063674846,0.03761454,1.7567088e-06,-0.037310377,0.059274178,0.10655381,0.04802434,0.11322626,-0.0745834,0.044469547,0.0006446452,-0.01623063,0.061672807,-0.059436694,0.07694041,0.052153386,0.017709907,-0.041140217,0.008722515,0.03681107,-0.0040885955,0.03471203,0.016383383,-0.010654711,0.029627588,-0.047692664,0.015606585,-0.033113107,-0.05058698,0.015047506,0.033727895,0.032362465,0.0038753655,-0.046817515,0.011042125,0.080256976,0.04087475,-0.04177007,-0.02760784,-0.023912113,-0.07294647,-0.059030484,0.06608976,-0.04351618,-0.098879054,-0.0032161195,0.07196567,-0.052178886,-0.1070994,-0.06752355,0.049284086,-0.02161987,-6.673318e-33,0.056292515,-0.0491568,0.09933552,-0.021574972,-0.054784022,0.02128688,-0.029833058,-0.015821584,-0.014866421,0.0075636804,0.04642942,0.0077106617,-0.037636608,-0.044624995,0.0052078343,-0.05583951,0.031265356,0.09404279,-0.058172368,0.035339747,-0.04997703,0.024289073,-0.00070628413,0.00694407,0.0643296,0.03275741,-0.011677805,0.08342788,0.026203873,0.048261885,0.017047463,-0.049389616,-0.053798787,-0.09057257,-0.027748004,0.13817155,-0.046731904,-0.010707967,0.04551572,-0.04552961,0.07667956,-0.014991,0.0025401278,0.05352067,0.023369849,0.033329356,-0.11437791,0.06474212,0.008541984,-0.103964426,-0.027227236,0.112706974,0.03197137,0.015148526,0.00083794515,0.000606603,0.054550897,-0.052934207,-0.014239163,-0.044600595,-0.06430184,-0.07426578,0.04384586,0.038819827,0.049880568,0.03258945,-0.031136977,-0.00023697445,0.102354065,-0.011070561,0.03917472,0.052530978,-0.034355965,0.0020938176,-0.030908193,0.04995821,-0.04271319,-0.1259966,-0.024408242,0.019562796,0.022403767,-0.025262749,0.033278253,-0.04692548,-0.08486756,-0.05424434,0.010355703,-0.00391996,0.0039461157,-0.003608304,0.0006822828,0.031234654,-0.0062594526,0.00924625,-0.0030615807,-4.038031e-08,0.08481267,0.027024569,0.06661271,-0.07631118,-0.006448553,-0.07280591,-0.09372727,-0.024859961,-0.016759818,0.006654948,-0.03338157,0.042536113,-0.008942994,-0.055418838,-0.006340208,-0.034801453,-0.07714373,0.005992751,-0.015109403,-0.013433357,-0.070599645,-0.022725768,-0.04816691,0.04470628,0.0685336,-0.07347697,0.009177942,-0.018383252,0.025571726,-0.00036482327,0.04328612,0.018403599,-0.054506917,0.056112014,-0.034941267,-0.0328626,-0.10082686,-0.073799156,0.032648742,-0.042282846,0.06370917,-0.029715085,-0.031851653,0.018091872,-0.10989546,0.026179265,-0.009616197,-0.046082653,-0.06192182,-0.0005070192,0.03723507,0.009457594,-0.046235904,0.0058558783,-0.09598319,-0.004648743,-0.01648359,-0.01579985,-0.015463817,-0.058063906,-0.06605261,-0.022353189,0.19210419,-0.06997877 +2.1.1.240,The enzyme catalyses the biosynthesis of pterostilbene from resveratrol. 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+2.1.1.241,"The enzyme is involved in the biosynthesis of the protective and allelophatic benzoxazinoid DIMBOA [(2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin] in some plants, most commonly from the family of Poaceae (grasses).",384,0.99999994,-0.08452821,0.045791242,-0.106969014,-0.017956229,0.010618384,0.0719081,-0.05460639,0.082423784,0.057650592,0.003448291,0.027314344,-0.02165127,-0.07823844,-0.034323428,-0.075645134,0.13300028,-0.008629836,0.004714173,-0.072817214,-0.010997281,0.0057250103,0.08588898,0.028128857,-0.004851852,-0.019127006,-0.026247494,-0.01369998,0.044002883,0.014425307,-0.07388265,0.09404987,0.043092836,0.07708944,-0.021849638,0.024315061,0.043465134,-0.023553027,-0.087838836,0.047277167,0.039950654,0.060363926,-0.02314742,-0.03941162,-0.00442646,-0.05965776,0.0001278143,0.050801218,0.057120744,0.05549493,-0.052360334,-0.029925754,-0.083732575,-0.021716781,0.049208082,-0.070782006,-0.008367631,-0.021885876,0.021251092,-0.09465097,0.023708366,0.013153129,0.060073733,-0.021405436,0.047701813,-0.019269796,-0.03351129,-0.015652336,-0.047646344,-0.0043493616,-0.09138629,-0.046718962,-0.09360288,-0.049718264,0.008446992,-0.11322645,-0.012585335,-0.038026333,0.06913551,0.075799756,-0.047653556,0.04640839,0.013898852,0.006426114,0.07403349,0.036874402,0.035789136,-0.021649035,0.064623505,0.10300472,-0.0005934484,0.02869866,-0.07030546,-0.029628005,0.07035251,-0.1043863,0.07252032,0.051189825,-0.044699118,0.02245407,0.040175322,-0.0042515383,-0.0272903,-0.0049307323,-0.08162885,-0.04494581,0.054360647,0.01655319,0.046999045,0.040250406,-0.06564416,-0.03834265,0.014026479,0.009175796,0.036090724,-0.04113837,0.03684053,0.045096714,-0.061334983,-0.01173832,-0.039515506,0.029123237,-0.02149654,0.082334675,0.010430881,-0.06609968,0.026939033,-0.13571095,5.2502656e-34,0.1021423,0.01327257,-0.052325916,-0.017916936,-0.038555816,0.00785247,-0.061403196,-0.023297139,-0.08169748,-0.008103362,-0.09231073,-0.09724206,0.09287991,-0.027976573,-0.01596695,0.025364652,-0.011852825,0.0010048893,0.04551408,-0.019890472,-0.0036219193,0.023326693,-0.08283835,0.023539817,-0.013305777,0.102225244,0.033565897,-0.019367168,-0.01320906,0.009604412,-0.030208059,-0.07999996,-0.07143275,0.0027511874,0.033793844,0.008419185,-0.104822494,-0.033788446,0.027716558,0.05783567,-0.042155486,-0.040007327,0.01585678,0.001700072,0.0916556,0.00475302,-0.08194237,0.1577526,0.041667785,0.08794014,0.0334949,-0.08343751,0.08449672,0.059072223,-0.078168735,0.029006207,-0.0054963524,0.05237786,0.05029376,0.0005035054,0.0042065093,0.031636246,-0.078735024,-0.004258843,0.014864377,-0.09396328,-0.051176157,0.010812221,-0.07722283,0.062257044,0.01601595,-0.026743904,0.012557915,0.047964852,0.050402295,-0.082743555,0.06597099,-0.012404392,0.04354234,0.057411168,0.04284968,-0.011182659,0.016420368,-0.085921936,-0.05231257,0.0051456364,-0.024421597,0.019792514,-0.03555354,-0.012441954,0.035599597,-0.037199136,-0.0048801536,-0.037304748,0.04887134,-1.9759603e-33,0.097704716,0.022280162,0.016362047,-0.059568707,0.047891706,0.024617594,-0.0095743975,0.0043508206,-0.025536131,0.0284176,0.017395474,0.008940016,-0.0056646205,-0.031529836,0.08597061,-0.009612231,-0.018408857,0.05140375,0.008829371,-0.03597467,-0.054031357,0.029289937,-0.03092188,-0.010738953,-0.025453225,-0.061224554,-0.02358261,0.047370005,-0.019381143,0.12386139,0.0154691655,-0.034581956,-0.08133122,-0.0073497267,0.043542106,0.048432644,-0.041305225,-0.01807682,0.033689883,-0.006006082,-0.05955867,-0.041432843,0.049290806,0.04311175,0.059969936,0.06984676,-0.14138278,-0.031185385,-0.058075424,0.011993386,0.02681132,0.052878484,0.07874614,0.0836835,0.025544826,0.018312844,0.014067511,-0.004155387,-0.005581103,-0.06786417,0.031287447,-0.042117618,0.032609444,0.06333555,-0.0039984128,0.060000673,0.01387258,0.0716702,-0.021190139,0.047330104,0.034644928,-0.005577556,-0.06699642,0.02437387,-0.061582856,0.021135848,-0.049027447,-0.023720585,-0.06416525,-0.010920189,0.023299258,0.028405601,0.067868106,-0.11199177,-0.05685821,-0.03264987,0.02718227,0.09958844,0.05214977,0.017868403,0.00015536165,0.007895328,-0.04781643,0.024553481,0.04879917,-4.2374268e-08,-0.05374134,-0.073617004,0.010215448,-0.056785967,-0.016236702,-0.056759577,-0.027871456,0.018914891,0.045463838,0.045741543,-0.011705917,0.07726852,-0.024058072,0.032587092,0.08674777,-0.015534913,0.0040646726,0.037915893,-0.009560028,0.06718969,0.022631839,0.039852504,0.011791974,-0.00020351136,0.026538698,-0.06695836,-0.014635175,-0.0129615255,0.05621769,-0.01572711,0.09098044,0.10415576,0.014463159,-0.030798472,-0.12872754,0.045461584,0.0065026158,-0.057143223,-0.032114167,-0.013216498,-0.020732746,-0.066130914,0.0014733063,-0.005559845,0.036284465,-0.049207363,0.022504216,-0.050852858,0.0023036464,-0.027735082,0.017717209,0.032980222,-0.014635071,-0.027931454,-0.11046146,-0.028014736,-0.005671337,-0.027167905,0.009180256,-0.07044807,-0.051361304,0.047066778,0.15090542,0.006990519 +2.1.1.242,The enzyme specifically methylates guanine1516 at N2 in 16S rRNA. 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+2.3.1.197,"The product, dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose, is a component of the glycan chain of the crystalline bacterial cell surface layer protein (S-layer glycoprotein) of Aneurinibacillus thermoaerophilus.",384,1.0,-0.07619161,-0.06926155,-0.07996679,-0.033875298,-0.001047868,0.018157305,0.03661934,0.08085103,0.04534807,-0.03165143,0.03214718,-0.019706491,0.0069290353,0.045063913,-0.09752374,-0.027237698,0.015327202,-0.009736195,0.06749205,0.021117805,0.08442325,0.09591431,-0.024317529,-0.05906719,0.054846402,-0.009485546,0.015317865,-0.050124686,-0.02486098,-0.055066507,-0.027708385,-0.08145193,0.050380588,0.037180692,0.03698001,0.06418666,-0.021395514,0.0060931914,0.06628782,0.015034494,0.008003337,0.023673827,-0.02468138,0.023394281,0.010991516,0.060850732,-0.029207641,0.025793234,0.034085784,0.0045581763,0.03051438,-0.011856363,-0.023059644,0.0090854075,0.024112651,0.04887127,-0.057822913,-0.012959674,-0.000574007,0.018553123,0.050979942,0.020430734,0.048590474,0.0008927284,0.039945558,-0.099254735,0.059571356,-0.023083026,-0.075660385,0.042202383,-0.01951464,0.007451136,0.055317968,-0.014014032,0.047722913,0.049128998,-0.034011167,-0.020245533,0.072511666,-0.052378897,0.04324822,-0.0020509071,0.021382378,0.14694877,-0.051912952,-0.071712635,0.040681742,-0.0106793465,-0.0031410204,0.014750404,0.006556046,-0.0028615436,-0.0028754014,-0.004752322,-0.06996753,-0.059892956,0.04298767,-0.028851159,0.016011756,-0.049983405,-0.058402847,-0.00065996597,0.030199962,-0.05349453,-0.0685339,0.0030005442,-0.048889484,0.015680969,0.12612925,0.0074447775,-0.033335555,0.029501708,-0.0069787456,-0.06681803,-0.031452827,-0.018611204,-0.028422942,-0.029632322,-0.0043559936,-0.06413442,0.019143099,-0.01801673,0.004102367,0.078076296,-0.021868046,-0.018567003,0.025235299,4.0292783e-34,0.09210542,0.06553172,-0.0391428,0.035648726,0.011272364,-0.024123784,-0.038249552,-0.08070011,-0.035451278,0.005943823,-0.12948456,-0.04128433,-0.06694289,0.16869158,-0.01905157,0.10147538,-0.017276019,-0.020500127,0.046070732,-0.015513252,-0.04305867,0.05498011,0.019911066,-0.019851498,0.0643487,0.02893142,-0.01741182,0.012432795,0.050679002,0.016650075,-0.006596812,-0.07342479,-0.06927941,0.011226125,0.06964226,0.060692545,-0.052763514,-0.034569986,0.011568245,0.020826686,-0.004492738,0.010200243,0.019321589,-0.030401358,-0.014061859,0.06242919,-0.0064819385,0.01956753,-0.050549388,0.02768616,0.033687152,-0.050168645,0.08016528,-0.03447229,-0.042871885,0.022857074,-0.09715617,0.06361459,0.022632409,0.049185302,0.06982637,0.04242103,-0.017339667,0.059405386,-0.020690253,0.05962926,-0.008179426,0.020508148,0.054835323,-0.039917916,-0.053884428,0.009165536,0.097969376,0.038957477,-0.05960349,-0.019341957,-0.039637472,-0.048894815,-0.0026883092,-0.031396378,-0.08398524,-0.031277154,-0.03138721,-0.08341988,-0.07824941,0.04376057,0.010806878,-0.035375677,-0.033441406,0.055553935,0.013128487,-0.065215215,-0.011453376,0.09506148,-0.06843875,-2.2882065e-33,0.07925472,-0.18068875,0.06306832,-0.076052554,-0.053319335,0.04620691,0.013065404,0.04397407,0.0025217775,0.03500298,0.025874069,0.022606075,-0.034781888,-0.060655467,0.03481722,0.07389932,-0.020685656,0.07452987,-0.062730834,-0.048117425,0.0072004017,-0.0005395607,-0.05018832,0.026767053,-0.04387116,0.08008096,0.0027858869,0.044232976,0.047845885,0.009410902,0.03290495,0.009622672,-0.020502083,-0.085373186,-0.09256933,0.07501515,0.016629457,-0.07769782,0.0060796114,-0.05057049,0.061926812,0.034713954,0.00013035003,0.024236329,0.093397304,0.114148565,0.030051712,0.0038249327,0.03812536,-0.023400465,0.03255145,-0.07447333,0.04029033,0.0019173975,-0.019189555,0.07725496,-0.005230234,0.024055608,-0.015625313,-0.019249981,-0.023153272,-0.058155052,0.022020308,-0.01520814,0.051166665,0.093318924,0.026028879,0.008992967,0.08755051,0.0075602434,0.014133916,-0.00851524,-0.069418915,0.007929879,-0.0058285617,-0.051209327,-0.102943026,-0.013787992,0.029155655,0.0076014767,-0.014921186,0.038453963,-0.00018391637,0.03469606,0.08219179,-0.05311388,0.03350249,0.10715294,-0.021357436,-0.010725003,-0.027515387,0.0066472366,-0.07509551,0.05303307,0.035804104,-3.8026787e-08,0.1440822,-0.051413715,0.056902196,-0.16011454,-0.038114235,0.000649018,0.039864045,0.112788096,0.031872947,-0.07424946,-0.029678661,0.07201092,-0.06407287,-0.07342444,0.015139544,0.05082116,-0.0876145,-0.02646333,-0.031480655,-0.0564528,-0.07914284,-0.007520379,-0.05834393,0.021750018,-0.04855748,-0.03365336,0.028727274,0.030012835,-0.011756043,-0.008413478,-0.005019362,0.041500624,-0.08564348,-0.033853386,-0.03900523,-0.002620023,-0.0365286,-0.05852843,0.04355589,0.017197829,0.024914116,0.046538156,-0.03101972,0.030766267,-0.022298064,0.0124701215,-0.07881332,0.032366965,-0.057086978,0.0353154,-0.035715967,0.016121252,-0.098082155,-0.0037809443,-0.14907427,-0.07442391,-0.007555535,-0.07023829,-0.02175014,-0.046068303,-0.05303022,-0.015316955,0.12550427,-0.008663916 +2.4.1.278,The enzyme is involved in erythromycin biosynthesis. ,384,1.0,-0.065713264,0.02176837,-0.1445861,0.0017441912,0.015603366,-0.0019410223,-0.017200662,0.06786926,0.08901283,-0.029606132,0.013390069,-0.007067249,0.04410157,0.017887441,-0.008389519,0.011772142,-0.070523836,0.034216743,-0.022518737,-0.1010557,0.05717465,0.025219396,0.037041143,0.012357722,0.08912503,-0.07517402,0.04723923,0.029428205,-0.053357743,-0.054221284,0.022703243,-0.063574225,0.055258334,-0.025446292,0.054244954,0.083298996,-0.06603518,-0.040656533,0.10768701,-0.022574252,0.0075626355,-0.0497772,-0.036087416,0.038488463,-0.032333653,0.012886709,-0.044166632,0.002427726,0.042231135,0.010826129,-0.04013334,0.0057728128,-0.06007962,-0.007824244,0.075616114,0.018357232,-0.016635835,-0.031516153,-0.013714607,0.024615047,0.096178874,-0.045296445,-0.019522127,-0.006867478,-0.08188336,-0.0442744,0.039582156,-0.09220338,0.013239006,-0.05104818,-0.08264246,-0.0787913,-0.055630676,0.08413722,0.042718146,-0.060256585,-0.051217735,0.055683598,-0.0553532,0.006879241,0.073241614,-0.013329847,0.010592549,0.09170196,0.05233661,0.054596554,0.051931966,0.030079795,0.012921917,0.054387823,0.030840307,-0.04847668,-0.035522614,-0.021987224,-0.039249457,-0.0071685542,-0.051396534,0.0055684736,0.01724062,-0.024156345,-0.0026986562,0.014991457,-0.01035906,-0.026640028,-0.0068189832,-0.01920934,0.040539175,0.07747744,-0.029166413,-0.057175495,-0.013800689,-0.026231531,0.044354253,0.020309739,-0.063965,0.12697923,0.049509786,-0.0429427,-0.08822989,0.020543732,0.02351582,0.030662656,0.016289154,0.07736913,-0.02658519,-0.042580433,-0.10286845,9.839299e-35,0.035108935,0.08630831,-0.055584773,-0.016127715,0.03677552,0.032203615,-0.04854707,-0.022437757,-0.042060863,-0.015314405,-0.06643726,-0.10340999,0.018874142,0.023336647,-0.02855182,-0.00096529425,0.0081841145,0.023791665,0.01593811,0.024754638,0.028891418,0.0004618223,-0.040532876,-0.0020543449,-0.0022246153,0.07993089,-0.053281426,0.048792943,0.085763864,-0.042608432,-0.0009402323,-0.09040201,-0.021108964,0.012686304,0.082240775,-0.0449748,-0.006906131,-0.014405846,0.07354765,0.0162453,-0.050795846,0.05053498,-0.0012440545,-0.0048782537,0.053363636,-0.024329111,-0.029739093,0.08289728,0.09254001,0.07137132,0.04190507,-0.026676072,0.16182725,-0.028045207,-0.047610506,0.03635419,-0.005400493,0.038412075,0.01330063,0.024690446,0.0077242623,0.026809694,0.008657828,-0.006264134,0.05843357,0.09083511,-0.04082589,-0.03705262,-0.040829655,0.103846096,-0.049757876,-0.04265659,0.052133694,0.0006380338,0.03501402,0.020872027,-0.10015632,0.0051874323,0.036537733,-0.015660388,-0.042870212,0.03859413,-0.009455074,0.005812408,-0.024884004,0.010385604,-0.047719635,-0.07403025,-0.0079387585,0.06826899,0.03770027,-0.10420133,-0.08941978,0.02950206,0.038291465,-1.5265904e-33,0.1411151,-0.043331817,0.02102846,-0.056963578,0.009708562,0.04995907,-0.023899743,-0.0041376,0.029906465,0.055612046,0.07364396,-0.007677451,-0.05847729,-0.046407066,-0.019199962,-0.0138741685,0.030618506,0.10036409,-0.04837835,0.021404523,-0.04307884,0.064670384,0.03545464,-0.01810838,0.030163556,0.02532228,0.01695442,0.042515114,0.003596353,0.012126122,-0.041905772,-0.086953826,-0.0929943,-0.07139773,-0.02413684,0.09909673,-0.025422854,0.011085848,-0.00509376,-0.06351955,0.06554902,-0.001035205,-0.013448572,0.032403093,0.05884215,0.029939324,-0.053583667,0.075304165,-0.032298908,-0.1030266,0.014097749,0.061183944,0.03680554,0.025612274,-0.040958483,0.021052033,0.085705,0.017077327,-0.0053258515,-0.019791963,-0.05899674,-0.033324685,0.051818,-0.0013208232,-0.01444427,0.03320237,-0.052727994,0.057999503,0.07645549,0.01638173,0.07884974,-0.012087777,-0.034430936,0.030694636,-0.0555605,0.010863136,-0.06187667,-0.10295352,0.016422013,0.031435173,-0.023052868,0.008473375,-0.059480406,-0.026353048,-0.07651912,-0.06361495,0.024236428,0.048339486,0.02573392,0.019322298,0.045256495,-0.0037391402,-0.030900972,0.07047317,0.0010053494,-2.0975367e-08,0.04471061,-0.041499093,0.041952975,-0.07169981,0.015790867,-0.043471083,0.009634236,0.037978824,-0.0025202767,0.011302873,-0.04062669,0.050304558,-0.03076711,-0.034487776,0.04751067,0.023065643,-0.005804681,0.066244915,0.017219212,0.0099718785,-0.024692426,-0.0316675,-0.11240037,0.018166952,0.07150422,-0.088476576,-0.017454421,-0.026366709,-0.0015439461,-0.0057048816,0.06422851,-0.0371322,-0.021388005,-0.0017664955,-0.064191595,-0.0050741737,-0.13380182,-0.061672706,0.015226316,-0.043168165,0.033981774,0.00026554352,-0.05354908,0.03822896,-0.062006615,0.087158784,-0.005407749,-0.08347123,-0.016624384,-0.021138519,0.033301692,-0.014394274,-0.0008752165,-0.05790842,-0.13710597,0.042307343,0.033430304,-0.06496735,0.009114946,-0.05046606,-0.044736777,0.015445366,0.23717439,-0.043005917 +2.5.1.98,"The enzyme is responsible for pyruvylation of the subterminal glucose in the acidic octasaccharide repeating unit of the exopolysaccharide of Rhizobium leguminosarum (bv. viciae strain VF39) which is necessary to establish nitrogen-fixing symbiosis with Pisum sativum, Vicia faba, and Vicia sativa.",384,1.0,-0.017236067,-0.082051896,-0.15935758,-0.06473958,-0.006068391,0.06087948,-0.031840645,0.01956129,-0.01905107,0.0351388,0.022867018,-0.010084528,-0.09268805,-0.007579699,-0.09712605,-0.031427775,-0.07289219,0.015493631,0.013755121,-0.018405607,0.10961011,0.002402245,0.034570985,-0.0052888975,0.01984595,0.032261275,-0.019000879,0.04066621,0.005189962,-0.13613048,-0.016559698,0.057427954,0.048982657,-0.08151469,0.060993914,0.12679562,-0.044819076,0.00041388837,0.033686683,-0.01914256,0.042324394,-0.07470056,0.062099833,0.015312791,-0.036497913,0.055841386,0.05682248,0.080147944,0.05470984,-0.043925107,-0.03695359,-0.021341002,-0.06459158,0.079552025,0.050409433,0.00895261,-0.008643465,-0.026513895,-0.03410579,-0.05080226,-0.02068467,0.0836166,-0.02313769,-0.037997935,-0.040311165,-0.04993555,-0.012262694,-0.09132703,-0.022058321,0.06818659,-0.0331865,-0.023422468,0.003814993,0.014864454,-0.020657364,0.04835455,-0.0054233964,-0.05054909,0.022651887,0.017213108,0.0014713879,0.036907434,0.019111035,0.06254659,-0.003346367,-0.060760755,0.06965488,-0.03794075,0.10302379,0.0037430744,0.045779023,0.023414493,0.04091769,0.01215463,-0.086916685,0.03255881,0.028307557,-0.015082592,0.05373874,-0.045148738,0.015157971,-0.0472987,0.049344487,-0.037425097,-0.0874216,0.016177068,-0.016703619,0.09152214,0.027134422,0.012205743,-0.037762493,0.057397068,-0.013719164,-0.009856998,-0.08664785,-0.0016195877,0.021138841,-0.09173085,-0.10165736,-0.046151534,-0.053031255,0.033500798,0.051656146,0.005983188,0.0033575387,0.0023685268,-0.11415492,5.937462e-33,0.03299961,-0.05002427,-0.0052859215,-0.062317416,0.05380675,0.025475277,-0.05134544,0.009487734,-0.020229362,-0.008766815,-0.11720835,0.0039030442,-0.0063716704,-0.0064090607,-0.076724276,0.034245763,-0.04217707,-0.0035230087,0.018470388,0.017609114,0.041315995,0.0200313,-0.038424682,-0.011151591,0.008202994,0.07300328,0.055668157,-0.025793163,0.029710816,-0.01609299,0.08587405,0.0011927508,-0.10149277,-0.022501005,0.094555445,-0.03854813,-0.0027335894,-0.012907733,-0.072556384,0.08369725,0.02427221,0.07865924,0.03726546,-0.012711633,0.02937042,-0.0064765033,-0.018643891,0.07460404,0.10091481,0.12683427,0.06780766,-0.038872432,0.09550416,0.057652995,-0.0335955,0.01666298,-0.05639938,0.027263,-0.039239995,0.004425865,0.0021345417,0.015391815,0.05051426,0.012091861,-0.019386487,0.017662413,-0.011691593,-0.047399323,0.068276696,-0.009880241,-0.111204065,-0.051497113,-0.0130513115,-0.010744373,-0.013739555,-0.081679985,-0.08271371,-0.015588403,-0.0045620287,-0.020133093,0.025228156,-0.045718014,0.001805,-0.053926058,-0.09122357,0.021113487,-0.060863875,-0.00032916505,-0.06348904,-0.01006696,0.08429855,-0.06377695,0.018049346,0.028350037,0.0075690676,-6.4656105e-33,0.107571535,-0.09794523,0.08951007,0.02603156,0.0059982794,-0.0111109335,0.028157454,-0.05084653,-0.034103777,0.012551076,0.02822668,0.010785936,0.048540484,0.062796235,0.011530562,0.02192477,-0.012988065,0.07103079,-0.02215805,-0.06497719,-0.07967202,0.108591914,-0.0035628334,-0.04543487,0.0464664,-0.0026835098,0.030793026,0.10908954,-0.010091522,-0.036848344,0.041694287,-0.005455869,-0.09738664,-0.05436507,-0.0013282003,-0.0037003842,0.015846062,0.0019068342,0.001100273,0.05774336,0.056525752,0.07051137,-0.034092315,0.039561544,0.037274547,-0.01058255,-0.08433926,0.02148621,0.028256753,-0.039440636,0.04023321,-0.043390013,-0.008444108,0.010269299,0.051133882,0.075308435,-0.030038407,0.09265431,-0.0129680475,0.030004878,-0.0005414211,-0.07241836,0.010995543,-0.02559128,0.03625502,0.09496894,0.049462084,-0.01796913,0.07454146,0.07597278,0.050016075,0.052402504,0.0051723314,0.07751579,-0.00839853,0.028465731,-0.026166914,-0.047426604,-0.014174221,-0.040119696,0.01611771,-0.07794611,0.03218825,-0.033924874,-0.07296677,-0.09082919,0.076384045,0.051943697,-0.034556184,0.061108425,0.020658955,-0.050086904,0.02629685,0.052041676,0.087467685,-4.049127e-08,0.038423,-0.06677415,-0.07832674,0.0018203987,0.028993627,0.055997882,-0.012190322,0.012644258,0.07522193,-0.001990541,0.0029892984,0.050756324,0.038868766,0.07498383,0.068132274,0.030088892,-0.028659916,0.034758195,-0.059725218,0.064950325,-0.07925932,-0.02702544,-0.15304747,0.062219672,0.011900358,-0.064670734,0.043047216,0.038939208,-0.016380457,-0.03960447,0.02721218,0.06833159,0.054345496,-0.058908068,-0.08468538,0.036172792,-0.047538552,-0.024304232,0.002163189,-0.0126817655,0.027060201,-0.045709316,-0.019285241,-0.025256118,-0.030518133,0.018657338,-0.088163935,-0.017130584,-0.079506464,-0.015025677,0.027430616,0.05282756,-0.03703626,-0.053319078,-0.06811497,0.0022156949,-0.028875193,-0.02549813,-0.025115164,-0.013668035,-0.022877771,0.029810056,0.06864351,-0.11778016 +2.7.7.81,Mg2+ is required for activity. 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+3.1.7.10,"The enzyme from the lycophyte Selaginella moellendorffii is bifunctional, initially forming (13E)-labda-7,13-dien-15-yl diphosphate, which is hydrolysed to the alcohol.",384,1.0,-0.048600268,-0.051406514,-0.07800362,-0.02869299,0.0028017326,0.06988134,0.0033627388,0.03771832,-0.022809885,-0.06410895,0.025243051,-0.07548155,-0.15960634,0.0419335,-0.052732926,0.06454767,-0.028541587,-0.035059977,-0.010746325,-0.020248787,0.10395577,0.030133596,0.076141715,0.02754191,0.08376702,-0.014665916,0.034532912,0.04035179,0.060795356,-0.077249594,0.047168057,0.06827007,0.05609263,-0.07756982,0.1254136,-0.010576659,0.0010294951,-0.11681984,0.06764192,0.02142327,0.07173449,-0.002464128,-0.053870894,0.014247285,-0.1393465,-0.01982574,0.015868373,-0.012694514,-0.0044918307,0.0059576407,-0.0035598539,-0.096255854,-0.10468559,-0.007902026,0.01757985,0.003580731,-0.022179754,0.06712863,0.0046722875,0.046872523,0.07312357,0.095575705,-0.04535275,0.042516835,0.03175078,-0.07132325,-0.04808892,-0.026258416,0.03823688,-0.07641351,-0.032864373,-0.09229196,0.019861944,-0.025121737,-0.02598759,-0.004607366,-0.027337568,-0.057729304,-0.017984161,0.0021119097,-0.037277874,-0.024762163,0.015254331,0.067379154,0.012668491,-0.05269531,0.00730979,0.014860756,0.011685335,-0.027070846,0.013756164,-0.017253278,-0.06839655,-0.10833516,0.030759128,0.118741006,0.045830246,-0.0008220343,0.04059094,0.014746615,-0.014233196,0.09316818,0.043787315,-0.11484589,-0.039818283,0.022918161,-0.022794003,0.034125987,0.04893362,-0.061805725,-0.026591852,-0.03773204,0.07640269,0.019979753,-0.02567126,0.09886395,0.01178702,-0.036509473,0.004315426,-0.04079178,0.022985203,-0.03673539,0.030146351,0.07918078,-0.06716473,0.05902644,-0.07881938,1.0159576e-33,0.09874917,-0.033777036,-0.02745913,-0.024560662,-0.022014204,-0.07175958,-0.022547383,-0.024750968,-0.13865328,0.007590326,-0.046065874,-0.03456981,0.04654143,0.025300361,-0.0079382,-0.027324108,-0.007335034,-0.019388998,0.05065256,0.028018719,0.029224614,0.072489314,-0.06012654,-5.484711e-05,-0.044803273,0.0032739055,0.022337172,0.0518731,0.018454691,0.012106533,0.03187979,-0.04788227,-0.097154446,0.015047122,0.087022595,-0.015527215,0.0030784018,-0.03924167,0.011870576,-0.05107023,0.036597762,0.013014284,0.023824912,-0.013732376,0.05776249,-0.00974859,-0.033678524,0.075173505,0.11289779,0.042044785,0.02474624,-0.06937784,0.031472344,-0.009167217,-0.076583214,0.105342686,0.019818358,0.033843998,0.045806635,0.068936914,-0.007253876,0.020895775,-0.021868223,0.011273937,0.08256387,0.03840182,-0.010165351,-0.08760881,0.031171972,-0.024860358,-0.0714445,-0.011510917,0.010696639,-0.021926137,0.043438558,-0.004717385,-0.018753786,-0.030665733,-0.05616926,0.02210567,0.047220487,0.011370297,0.0005536768,-0.046122346,-0.06305475,-0.07963199,-0.027772037,-0.03208605,-0.026339745,0.04770755,-0.0010276899,-0.08256102,0.026104229,0.010392151,0.005769353,-2.6231505e-33,0.09317594,-0.15081365,0.006186928,-0.096841484,-0.07713215,0.03316253,0.07695086,0.0048626424,-0.02040129,0.038308203,0.051417984,0.0032288209,0.014350377,-0.04789277,-0.040263325,0.046638235,-0.0017714774,0.06898826,0.04136689,0.013039248,-0.042127274,0.063443206,0.034291968,0.07294155,0.0132855065,0.029004531,0.03529352,-0.03982749,-0.0039008216,0.045384806,-0.053233705,-0.03256024,-0.008215692,-0.05120916,-0.094255485,0.03933265,-0.018992445,-0.034931477,-0.036091935,-0.018110748,0.017256062,0.027385805,-0.024412554,0.00056737586,0.07905468,-0.010537529,-0.09529206,0.010127754,-0.046264406,0.033752196,-0.012403736,0.004566615,0.013610076,-0.008733956,0.007701574,0.04595485,0.030204302,-0.0059854113,-0.03130448,-0.028364066,0.036464553,-0.00953699,0.028397448,0.057793435,0.07057121,0.0373445,-0.11581435,0.0042854818,0.014077241,-0.0094806105,0.0974364,0.028483959,-0.007338008,0.06162476,-0.0041526575,-0.08891449,-0.012818758,-0.032748643,-0.022155786,-0.012243859,0.051343996,0.048031315,-0.04562979,-0.050100546,-0.0028732237,-0.104968145,0.047866054,0.11414477,0.027857665,-0.015190264,0.062740654,-0.03853388,-0.08681226,0.076672375,0.12063725,-3.706364e-08,0.0076593556,-0.019911323,0.04575412,0.00924733,-0.012700618,-0.0282623,0.07999925,0.017333219,0.013703961,0.017876012,-0.016627805,0.03213922,0.02220833,-0.036502518,0.030385267,0.028123403,-0.023814103,0.052286178,-0.03022793,-0.0114909485,0.05642022,0.002456362,-0.015962059,0.053977977,-0.033044808,-0.06533914,-0.024687286,0.087825954,0.0045917174,-0.013790045,0.009203171,0.03883457,0.014191906,-0.054830577,-0.06430588,0.05146686,-0.019740153,-0.07149166,-0.06328597,0.010480812,-0.031456344,-0.034400005,-0.007887293,-0.03270145,0.014860547,0.043814722,0.02858113,0.051621027,0.085455716,0.05364624,0.051369067,-0.0047841724,-0.0053889817,-0.07163549,-0.09395591,-0.004037992,-0.08559763,-0.035092477,-0.037375443,-0.08005552,0.0059857024,0.042122606,0.17485154,-0.064937964 +3.4.19.14,"The mouse enzyme is specific for leukotriene C4, while the human enzyme also has considerable activity towards glutathione and oxidized glutathione (cf. EC 3.4.19.13, glutathione hydrolase) [3-4].",384,0.99999994,-0.001977916,-0.022653818,-0.028156487,-0.030914102,0.022268089,0.045021173,-0.035932373,0.09007815,-0.023328999,-0.038150527,-0.019650077,-0.039877184,-0.073517404,0.06111485,-0.00538676,0.008852728,-0.016843913,0.012527765,-0.092085265,-0.089184605,-0.013140327,-0.076477684,-0.024634356,-0.007122218,0.022890048,-0.05301716,0.08924155,-0.03901908,-0.03236953,0.05179446,-0.061200798,-0.10710986,0.011067154,0.031210985,-0.01718357,0.026464626,-0.10605777,-0.031224169,-0.004350091,0.019558772,0.020915283,0.0023141517,-0.021233175,0.0043405225,-0.016874027,-0.019733805,-0.0268695,-0.08379124,-0.018212592,0.11351268,-0.02356281,0.04308843,-0.06634682,0.018604532,0.026323702,-0.021798287,-0.014937689,-0.04781092,0.0074429126,0.083905615,0.009315603,-0.056694426,0.003016956,-0.035419375,0.09506659,-0.034060482,0.010036629,-0.03463969,-0.07049936,-0.104105,-0.042362235,-0.04410187,-0.011125892,0.021966338,-0.008677675,-0.0071658376,-0.12297811,-0.039706353,0.050594565,-0.06979098,0.09715029,0.049595874,0.03445281,0.07018079,0.048690345,0.024982935,-0.029559609,0.022545926,-0.0080425935,0.006814371,0.019587165,0.017060632,-0.10821942,-0.026197603,-0.028511189,0.06778698,0.036309052,0.025871262,-0.023935996,-0.02230936,-0.015585046,0.014744876,-0.052897666,-0.07410603,-0.049278434,0.026486145,0.018682957,0.052052923,-0.017021025,-0.01606199,0.00022246953,0.013087917,-0.085777946,0.033665206,0.045464784,0.033431362,0.071883634,-0.058955655,-0.07964632,0.044108324,0.013193088,0.02955505,0.11463538,0.023630455,0.037368726,0.011013547,0.0239474,2.1535045e-33,0.05075725,0.027679391,0.07211602,-0.000197028,-0.04630416,0.062788226,-0.030649591,0.07453193,-0.02123736,-0.07201078,-0.030361693,-0.026420124,-0.03796924,0.011806976,-0.057500023,0.06103941,0.066107176,-0.03598216,0.06195088,-0.018272625,0.08609851,0.007613782,-0.009413931,0.040710673,0.012003975,-0.009850784,-0.021221375,0.055358544,0.0016508809,-0.0091811,-0.056531094,-0.018446509,-0.07483307,-0.048548564,0.030951373,-0.03620292,-0.046059113,-0.05295066,-0.013487407,0.03929626,-0.0074539445,-0.033399563,-0.016635172,-0.13715921,0.057544556,0.011985551,-0.11136513,0.018503059,-0.008625156,0.06725112,0.039470527,0.021921545,0.086730264,-0.010607812,-0.026646936,-0.029129656,-0.01638309,-0.07759059,-0.020827787,0.0881834,0.042373676,0.08617379,-0.06600973,0.0012921937,0.061226934,-0.0026799832,-0.07284472,-0.014959561,-0.10802426,0.12350411,0.034995057,-0.12938483,0.062248148,0.03315981,0.0072035394,-0.010804489,-0.047873445,0.13465717,-0.03460211,-0.031146517,-0.02664675,0.06866229,-0.029823978,-0.0056996797,-0.073587395,-0.023578605,-0.003369227,-0.0513915,0.08458569,0.020624053,0.085406736,-0.03008803,-0.06666572,0.023982635,-0.03782234,-4.6782758e-33,0.034618415,-0.05750091,0.037272383,-0.033108257,0.0039049846,0.112720594,0.05885368,-0.057135012,0.06427704,0.068546325,0.092172526,-0.0055408124,-0.00019017357,-0.009988863,0.08867193,0.012630152,-0.08747652,0.09611612,0.007813682,-0.0059877555,0.039961357,-0.0020843588,-0.012682433,0.07034565,0.11021005,-0.018106064,0.0206272,0.055005398,0.07164887,0.06624443,-0.02456252,0.033660553,-0.055108145,-0.02610824,0.07491868,-0.037922118,-0.03465215,0.017797353,-0.016940305,0.010084167,-0.039729882,0.05840851,0.041692644,0.09276255,0.06258378,0.044070493,-0.090270564,0.014498728,0.0005280729,-0.03383115,0.036301367,-0.036558013,-0.039515793,-0.10021225,0.044814076,0.050495144,0.058040068,-0.08672394,0.006815278,-0.06502709,-0.081372425,-0.05718743,-0.02177915,0.06767948,-0.032457877,-0.004294558,-0.010843547,0.00021438497,-0.002125039,0.019082602,0.084939316,-0.061840083,0.045368534,0.0030821338,-0.034547538,0.048572477,0.03491639,-0.021692652,-0.021074958,-0.017263759,-0.0014541709,0.0025061348,0.02467048,-0.06776987,-0.09250214,-0.03007323,0.01175747,0.13170962,0.026889987,-0.0045413906,-0.05111278,0.020999616,-0.10191286,0.0023651624,0.014822245,-4.0083005e-08,-0.0017135645,0.0016506134,0.06772707,-0.033589374,-0.045613784,-0.012479075,0.038964838,0.031600684,0.047005456,0.055623025,-0.02958173,0.099101275,0.005806348,0.026637377,0.0036659746,0.01823655,-0.041496065,-0.028330551,0.03853077,0.08672023,-0.051619448,-0.021965662,-0.07707021,-0.012847798,-0.045382153,-0.092811994,-0.013117174,0.079887696,-0.006861497,-0.0244152,0.07057274,-0.009580644,0.058981825,-0.0150765,-0.050134312,-0.04199198,0.05465318,-0.0009955594,-0.039242085,-0.0064200438,-0.0075019775,-0.04420635,-0.01373996,-0.0027405769,0.02365118,-0.026025744,0.0039675855,-0.036002103,-0.0029571368,-0.00029673422,-0.0830645,-0.024811292,-0.039027102,-0.032576945,0.0030393994,-0.0066203214,-0.05343531,-0.078493476,0.01987411,-0.13239665,0.01832609,0.05030857,0.14974704,0.058027185 +3.5.4.32,"Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions. +",384,0.99999994,-0.09352522,-0.01565779,0.003411387,0.05459626,0.08435426,-0.05326235,0.037801333,0.052815475,0.020475203,0.0102266045,0.07332078,0.04321176,-0.061103307,0.03939325,-0.115825,0.052939117,-0.11635497,0.030804705,-0.019281996,0.018061636,0.062585875,0.06035214,0.08697561,-0.008752749,0.006495245,-0.017539125,-0.023563579,0.028362181,0.054103885,-0.04711607,0.013948805,0.016848821,0.010881613,0.023582406,-0.027347453,-0.03473195,0.045337953,-0.023234196,0.020356242,0.009990726,0.042942822,0.040928755,-0.021413961,0.013959709,0.0654169,-0.0038501683,0.048477188,-0.044274963,-0.08693369,0.076685265,0.012100039,-0.071724184,-0.039232533,0.05788832,0.0297818,0.06739559,-0.09992461,-0.032194745,0.027814684,0.014195089,0.048167817,0.010605079,-0.0015616388,-0.020223629,0.08430878,-0.04406721,0.08290397,-0.032955017,-0.03021714,-0.02089235,0.028819077,0.021863798,-0.010624735,-0.06564253,-0.060713775,0.084568895,0.036376335,-0.09983589,0.0065152072,-0.036030225,0.043362103,0.0013021284,0.06661329,0.0811921,0.06534728,-0.037570495,-0.015066276,0.018082041,-0.024873976,0.089752406,-0.021530012,0.06363403,0.058297627,0.019341234,-0.032742422,0.012700502,0.04709192,0.07561066,0.01586401,0.023630615,0.050147876,0.05658765,-0.014957754,-0.08404279,-0.022921532,0.02170077,0.06370854,-0.00898315,-0.030197477,0.059512105,0.011171461,0.0048987176,0.009716761,-0.017492877,0.0075675063,0.061970472,-0.028006978,0.013672119,-0.08941919,-0.011057139,-0.038476758,0.0131708,-0.05717524,-0.007950657,-0.04743547,-0.012421171,-0.0753398,1.4421802e-33,0.040327165,0.055358186,-0.049778737,0.074813604,0.020557344,0.043315984,-0.069258906,-0.011847339,-0.06406095,0.04087596,-0.13986334,-0.061371922,0.01474117,0.028292334,-0.06981344,-0.031106383,-0.029089468,-0.037346624,0.014047191,0.0017000716,0.036061198,-0.0046195453,-0.0624092,-0.055657152,0.017559387,0.04769884,-0.035214152,-0.04673757,0.00015064614,-0.03633409,0.014539986,-0.11403298,-0.09949566,0.010704934,0.14402993,-0.03480799,0.03740227,-0.024227511,-0.0045613786,0.039438684,0.008148861,-0.027214648,-0.04862866,-0.009972033,0.108779944,-0.0023924098,-0.06730473,0.062352065,0.057789892,0.03961791,0.009322581,-0.06092468,-0.03583278,0.023341497,-0.07849422,-0.009238782,-0.052787215,-0.024667848,0.08642081,0.021321585,0.07163765,-0.0054322905,-0.016642353,-0.011102308,0.01177012,0.08860904,-0.07638097,-0.07486457,0.021689571,0.016767109,0.016394474,-0.09426637,0.044964,0.053303882,0.078382775,0.007606898,-0.1135827,0.049157057,0.061291978,0.04026162,-0.0490502,-0.03311317,-0.07569396,-0.020319164,-0.07638546,-0.06278975,-0.014283201,-0.01854949,-0.0026223962,0.08919648,0.06382874,-0.087466724,-0.0007167637,-0.1134988,0.03701535,-1.686031e-33,-0.008904636,0.00015955442,-0.019067552,-0.08261139,-0.0687663,-0.016294563,-0.008214296,-0.08369817,-0.0035450738,-0.032252684,0.07899581,0.021282274,0.037592772,-0.045796357,0.016164953,-0.041645262,-0.05656209,0.116114646,0.075655855,-0.03957769,0.041424338,0.0009462895,-0.019555287,0.06786018,0.067564614,0.015194035,-0.004739265,0.016618256,0.09091005,0.074742645,-0.11674959,-0.018416887,-0.05700394,0.011584744,-0.007602621,0.049485087,-0.008059426,-0.009828334,-0.060004037,-0.037889503,-0.04846624,-0.052622624,-0.02584441,0.10441053,0.025401898,0.09259032,-0.033385076,-0.0238846,-0.028456548,-0.0030073144,0.1020129,0.038366184,-0.04254398,-0.05068654,0.07463742,0.06546154,-0.021254068,-0.040154126,0.014265807,0.003712309,0.026580907,-0.05941039,0.0085457135,-0.05582266,-0.017632598,0.048946258,0.021604119,0.12820302,0.03201618,-0.080959454,0.04601867,0.05713354,0.083844155,-0.037423212,-0.032341674,-0.029300896,-0.012201063,-0.030087745,0.041928094,-0.0867214,-0.046136037,-0.011437053,0.027687622,-0.029550312,0.016256534,-0.01838223,0.01555234,0.07103256,-0.0018387455,-0.04205617,-0.0023695922,0.029275047,-0.049774278,0.034823563,-0.072634585,-3.663518e-08,-0.03487016,-0.07388355,0.084806934,-0.017903414,0.030729359,0.016404752,0.046881747,0.060384654,0.009396867,-0.02269646,0.016995825,0.10023898,0.02259192,-0.037217457,0.07540451,0.009535813,-0.07706338,0.012727278,-0.042616896,0.021285145,-0.020538311,0.03646087,-0.11163204,0.063733876,0.00094736274,-0.036386464,-0.007897045,0.03758251,-0.027160233,-0.07015948,0.12284576,0.01872184,0.056233242,-0.029763298,-0.048676163,-0.006227364,0.035867322,-0.047055207,-0.06292243,-0.07953478,-0.11091464,-0.036895882,0.025899706,0.00070705893,-0.0048495526,-0.0513445,-0.007914862,0.015635675,0.01054429,0.02493047,0.053895064,-0.022255933,0.008352581,-0.060520295,-0.03220072,-0.057644982,0.06943308,-0.017350234,-0.010504469,-0.001462273,-0.0212435,0.008183382,0.11242044,-0.043931972 +3.6.1.58,"The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [1,2]. Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase) [4]. The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate [6].",384,1.0,-0.038710937,-0.07560005,0.039544433,-0.067466475,0.0718244,-0.044998687,-0.07645183,0.07904201,0.008617572,0.014249806,-0.060975496,0.058336306,-0.076453045,0.0646558,-0.086985044,0.040898323,-0.0084182015,0.015867788,0.018164989,-0.014903055,0.066753484,0.033277024,-0.06402515,-0.01770979,0.049747355,-0.04057099,0.06573644,0.035355866,-0.036063068,-0.069420695,-0.03625054,0.003378314,-0.018227886,-0.074892394,0.023594243,0.14818391,-0.038121425,-0.04199451,-0.02153957,-0.027226731,0.07257155,-0.022161279,-0.023389881,-0.06751623,-0.0067780684,-0.009876944,-0.028882785,0.054179348,0.0112729035,0.070741616,0.0019407643,-0.014657727,-0.021485133,-0.014832727,0.049788594,-0.04600127,-0.04233505,0.00081809104,-0.0388466,0.031010918,-0.06734851,-0.00042492224,-0.0008435004,-0.038522333,0.11499574,-0.031175194,0.06118432,-0.03209767,-0.040707458,0.009947696,-0.0722472,-0.045308314,-0.019514395,0.027929265,-0.06938999,0.01057932,0.016964553,-0.06665343,0.08125459,-0.08825447,-0.0019930783,0.04380699,0.06924795,0.015658932,0.04549177,0.029642075,-0.04356602,0.058977153,0.022870746,0.017850798,-0.03907633,0.0760889,0.004878845,-0.011691527,0.0023919675,0.028839935,-0.048302855,0.09771516,-0.07684202,-0.04610057,0.027867818,0.113243185,-0.076600336,-0.08439069,0.002116772,0.039727688,0.024666779,0.05042804,0.027626516,0.024453955,-0.0054445886,0.06729214,-0.013628393,0.000621299,-0.017339144,0.028191945,-0.06934529,-0.057832554,-0.071560904,-0.053917352,0.00404092,-0.011157677,0.035765156,0.095931195,0.008742211,0.062021557,0.007384287,4.2885704e-33,0.023823563,0.033453446,-0.035674542,0.03740288,-0.012023301,0.0036202527,-0.072781295,0.03444927,-0.06373342,0.050579313,-0.032589093,-0.054267116,0.038474586,-0.027255569,0.011750607,-0.044552237,0.054581147,0.05458788,0.034241542,0.01149573,0.038166292,0.054367047,-0.06983078,0.027375758,0.022425234,0.056280818,-0.071860455,0.032215167,0.07718712,-0.039423864,-0.038487624,-0.100634,-0.10451039,-0.028891979,-0.0013849314,-0.08771394,-0.04136524,-0.035078157,0.020019835,0.09019531,0.031048555,0.005106042,-0.0032694861,-0.02899632,0.04729294,-0.03787109,0.017754374,0.035282373,0.017351145,-0.01627907,0.036792126,-0.03002087,0.06834165,-0.072524674,-0.067474835,-0.011003598,-0.029660804,-0.02783001,0.08502334,0.08259572,0.0067307525,-0.019878427,-0.033313,0.0127834715,0.025754044,-0.00251706,-0.031731464,-0.08470705,0.04562625,0.06409751,-0.03414197,0.012016667,0.09697154,0.047526803,0.012418991,-0.057953145,0.03480849,0.06581255,0.0407381,0.023243923,0.033863276,0.025183195,-0.021265702,-0.044513553,0.039802484,0.036261376,0.03812034,-0.089678526,-0.029002067,0.07578317,0.06329408,-0.11882892,-0.06905907,-0.02668485,0.0077077155,-4.164336e-33,0.03233932,-0.0327015,-0.025597649,-0.087757066,-0.072085515,0.015014117,0.081326835,-0.040514387,0.038568437,-0.11684615,0.07962548,-0.018308917,0.027229184,-0.04781322,-0.043028064,0.0006695283,-0.019735575,0.08881998,-0.008908725,-0.071224734,0.041943554,0.09698053,-0.02199554,0.07100842,0.07873836,0.030403823,-0.033358302,0.027947491,0.0673291,0.081123985,-0.0009657369,0.088623025,-0.03495207,0.0051865345,0.03751697,0.09152453,-0.08035167,0.038508903,-0.007042483,0.05017596,-0.03231348,0.09629506,0.0117700575,-0.0009667022,-0.010160776,0.088082954,-0.08042779,-0.013047172,-0.04102131,0.0033996736,0.055655763,-0.0024682502,-0.05406186,0.05348498,0.020838216,0.0025045082,0.040115856,-0.0021703823,0.041222103,-0.062115286,-0.019284632,-0.02844681,0.03666576,-0.018567637,0.006509819,0.16673702,-0.0060416646,0.03403493,-0.0104143815,0.016953504,-0.018648732,-0.017063815,0.045689598,-0.050763473,0.012526646,-0.016496748,0.0018826507,0.070604816,0.004489598,-0.067199856,-0.026464265,0.010156247,-0.050850283,-0.053975947,-0.021479089,-0.060629394,0.039754882,0.12192265,0.027286608,0.03340413,-0.06152569,-0.053608842,-0.08965038,0.0038289167,0.02453773,-4.9540045e-08,0.03824077,-0.05545343,0.046109088,-0.07856224,0.0010107175,0.017181206,0.016492972,0.027770279,0.043943465,-0.013762903,-0.0076160543,0.07123606,-0.04469673,-0.09756599,0.04076534,-0.027252514,-0.053614628,0.038146064,-0.030132439,0.020569466,0.00015485281,0.0648479,-0.104049,0.0705034,-0.017340776,0.018896822,0.021538926,-0.061606843,0.07291745,-0.05435503,0.03525231,0.09222705,0.037058577,-0.041435115,-0.027504353,0.009137604,-0.010319561,0.092521325,-0.048759818,0.06805176,-0.032345377,-0.106165744,-0.062869415,0.008750409,-0.0066973427,-0.017820736,-0.0077075497,0.022479525,0.013156741,0.0064746393,0.015491976,0.013947754,-0.031564932,-0.06928812,-0.07649014,-0.045684073,-0.032238565,-0.08204761,-0.029044943,-0.050948627,-0.015047867,-0.007554339,0.176674,-0.05364814 +3.6.1.59,"The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] [4]. +",384,1.0,-0.013759938,0.011559468,0.030336179,-0.049544998,0.012014577,-0.035819843,0.0039409855,-0.004780968,-0.018212514,0.011739239,0.021008339,0.027475541,-0.088008314,0.09743389,-0.11360764,0.012403324,-0.106345445,-0.015446102,-0.0079062665,-0.055130854,0.075846605,0.110469304,-0.04526501,-0.016189223,0.04739231,0.040644076,0.027591811,-0.026022503,0.048151214,-0.09388819,-0.019512977,-0.031501614,0.061579663,0.01771054,-0.008582936,0.07540632,-0.074037425,-0.0033985092,0.059173457,0.10430805,0.045146637,0.058785334,-0.037706424,-0.009294082,0.00074517867,-0.030521333,-0.10747419,0.025428215,0.03241558,0.009844913,0.017939156,-0.019885812,-0.0029621767,0.029762136,-0.03397201,0.041018,-0.006949102,-0.061415445,-0.07498414,0.015718509,0.03722162,-0.054734368,-0.040861268,-0.040581703,0.108126424,-0.013653066,0.061814286,-0.008874058,-0.036563184,0.08413552,-0.02825981,0.0010842883,-0.042438667,-0.0038313544,-0.08508347,0.034543496,-0.05065618,-0.009633265,0.014123277,0.046768352,0.006835092,0.0016893753,0.09359125,0.012950105,-0.026552776,0.07082145,-0.054407384,0.025083594,0.0017801233,0.027373029,0.037017394,0.06164619,0.02128863,0.043674365,-0.055301186,-0.0008809368,0.008764494,0.10512594,-0.036204204,-0.016391637,0.018839076,0.046681073,-0.110088855,-0.09935058,-0.034737814,0.019988,0.04979473,-0.0021908937,-0.033116408,0.026027946,-0.050938345,0.032029863,-0.016929803,0.052075736,0.0045743813,0.092028156,0.0423511,0.0273633,-0.039924294,-0.025006095,0.015455602,-0.046024013,-0.031604525,-0.013672413,-0.045468684,0.07491337,-0.034337528,1.4666382e-33,-0.00028597764,-0.026000833,-0.06092111,0.038724244,0.00384149,0.053965203,-0.10290074,-0.0006542151,-0.07572999,-0.046163928,-0.02662645,-0.040562343,-0.0054912237,-0.016723752,0.0075192745,-0.03560706,0.042214923,0.052786555,0.0050116214,-0.046639543,0.08913389,0.033137586,-0.05622675,-0.040981177,-0.019650744,0.058619563,-0.08647625,-0.0075295432,0.011004612,-0.028155327,-0.05210295,-0.018567467,-0.08166882,0.069228366,0.07899385,-0.0056851315,-0.023960354,-0.011749682,-0.02653269,0.061202392,0.027065845,0.055506587,-0.002921366,-0.04298986,0.026868446,-0.04499528,-0.031762034,0.039870825,-0.041909244,0.02538792,0.08656697,-0.0020989052,0.021819945,-0.10682462,-0.04324409,0.0035464615,0.020094719,-0.08747419,-0.04576838,0.04943732,0.027475424,-0.05477405,-0.027130838,0.036381204,0.086891964,0.055286206,-0.07001769,-0.07445281,0.014058932,0.045921598,-0.03922627,-0.019942349,0.06606396,0.055714183,-0.06888256,-0.014111639,-0.0071318923,0.017994583,0.023322199,0.037067477,0.033926878,-0.032166764,-0.062440302,-0.105441324,0.04382175,-0.06237444,0.05058788,-0.074050166,0.037817203,0.03473214,0.042579178,-0.041761562,-0.09309015,-0.033030756,0.041060504,-2.3921951e-33,0.08287202,-0.056497157,-0.04599921,0.004689955,-0.102368236,0.05697049,0.061700214,0.022110024,0.00683347,-0.08210108,0.010200615,0.056008857,0.07141819,-0.01511006,-0.00049491046,0.03702225,0.047524035,0.029656164,-0.010452409,-0.08660394,-0.0012675595,0.082154624,-0.029511126,0.02101958,0.052704312,0.0003828453,-0.0046333736,0.041569296,0.0586269,-0.015461181,-0.05068721,-0.010162731,-0.010037388,-0.034024123,-0.01183159,0.041756626,-0.0047212862,0.022755425,0.06951506,-0.024603402,0.020741867,0.062138394,0.01785037,0.07125442,0.0056961495,0.010823222,-0.09321232,0.013922858,-0.015564672,-0.06297455,0.040543307,-0.037566375,0.023161639,0.05746477,0.033335958,0.009025762,0.03274084,-0.021097079,0.00997258,0.018133484,-0.018981718,-0.0424506,-0.05228599,-0.00945284,0.034182448,-0.010592634,-0.01674517,0.08719123,-0.032492578,-0.111729965,0.04256324,-0.003915613,0.057414882,0.014832695,-0.07832562,-0.07727835,-0.09442068,0.010851149,-0.025282128,-0.046666488,-0.06936765,-0.026972417,-0.044106673,-0.027684618,0.06294813,-0.07803658,0.019503739,0.08988305,0.002123611,0.059167195,0.022043655,-0.12152684,-0.054332998,0.093160145,-0.0048894645,-3.886254e-08,0.022306127,-0.08159676,0.0025969336,-0.09393994,0.0017162021,0.047562003,0.0062629976,0.060603946,0.08908892,-0.02321809,0.0497812,0.039660424,-0.06572295,0.091845915,0.02420336,0.07868135,-0.03962229,0.03221943,0.023092465,0.0044826968,-0.093865134,-0.0074965353,-0.092849255,0.035453115,-0.053059958,0.023382813,0.10713759,0.1563005,0.048614517,-0.08902825,-0.023783064,0.04594319,0.10476877,-0.045505922,-0.018356673,0.030440029,0.05595014,-0.015416725,0.0323821,0.099287815,-0.01242236,0.023043195,-0.057679392,-0.01975699,-0.048871152,-0.040513635,0.037818175,0.065166615,0.007965433,0.04448624,0.05139562,0.024320971,-0.039749783,-0.031292226,-0.043402974,-0.022283124,-0.016346866,-0.0045354655,-0.03743972,0.027903702,-0.028937336,-0.0011767391,0.19958358,-0.054341104 +3.6.1.60,"A divalent cation is essential for activity. Mn2+ (2--6 mM) is most effective. +The enzyme controls intracellular levels of P1,P5-bis(5'-adenosyl)pentaphosphate and P1,P6-bis(5'-adenosyl)hexaphosphate. Weak activity with P1,P4-bis(5'-adenosyl)tetraphosphate. Marked preference for adenine over guanine nucleotides. ",384,0.99999994,0.073656805,-0.114923365,0.022574974,0.0083483,0.0073825526,0.01711729,0.05195845,0.055409648,-0.0044502807,0.09678076,0.014214245,0.05658581,0.013836666,0.1126828,0.021494003,0.0677899,-0.06565493,-0.014635083,0.03196388,0.009534738,0.049294375,0.0039781653,-0.011694553,-0.057862245,0.0018250531,0.03930427,0.050316185,-0.015568293,-0.023266282,-0.06352689,-0.058789488,-0.013256267,0.094787255,-0.03891081,0.017318487,0.12526873,-0.033614907,-0.014617494,-0.06131646,0.0017472074,0.047280565,-0.020933254,0.042753037,-0.05058964,-0.020734137,-0.040686306,0.06402355,-0.072003104,-0.0149776535,0.07522837,0.0066145845,-0.05347162,0.0071073994,0.024048375,0.028282363,-0.016493604,-0.09115555,0.05777261,-0.034329716,-0.037889626,-0.01699418,-0.03312931,0.0015509616,0.011534312,0.08288396,-0.02581833,0.06419052,-0.03085135,-0.022987569,0.027570201,0.012856677,0.004272856,0.0052627493,-0.06423994,-0.044530865,0.014924111,0.011351469,-0.049573153,0.021466125,-0.010246992,-0.003806977,0.011748403,0.046946526,0.039262805,0.078716956,0.08559425,0.031951286,0.0070956037,-0.009549143,0.04130859,0.038535673,0.062084265,0.02497562,-0.0033202192,-0.08121758,-0.03632722,-0.03246933,-0.03572659,0.0075520556,-0.02333989,0.04662384,0.07933345,-0.14186056,-0.013934113,0.050282143,0.030081812,-0.009798948,-0.015577749,-0.020167615,0.07329662,0.018162454,0.061508264,-0.024724597,0.058683123,0.030175278,0.067164816,0.056602027,-0.06031676,0.0007244648,0.019102825,-0.0019284624,-0.032930065,-0.023958875,0.0747435,-0.06456647,0.06830538,-0.025414938,4.799705e-33,0.047744557,-0.018591078,0.0240558,0.019009981,0.04110262,0.03844267,-0.037651412,-0.028704084,-0.004480625,-0.03129408,-0.077449456,-0.04502207,0.11004352,0.0011545543,0.013851654,-0.041758396,-0.039494164,0.021406136,0.14678106,-0.063087575,-0.018930817,-0.012172831,-0.0103012845,0.01285342,0.014570938,0.04108557,0.049933318,0.0393759,0.02962974,-0.038417526,0.005548822,-0.15827124,-0.060985114,-0.035678033,0.024588492,-0.02322003,-0.10560901,0.0280907,-0.030849654,0.033862248,-0.029616447,-0.007837059,-0.040086444,0.016584022,0.04948539,-0.07329489,-0.038393933,0.03976577,-0.054385044,0.021946205,0.06362127,-0.03443053,0.06406536,-0.04588593,-0.069684885,-0.014417433,-0.039399184,-0.057984766,-0.026087832,0.07505101,0.027545393,-0.025880042,0.031386316,0.03626926,0.013996244,0.029072532,-0.06740113,-0.10892067,-0.004689902,0.106129594,-0.022653246,-0.09017011,0.117480606,-0.011748188,-0.02270286,0.030092087,-0.025725529,0.015090067,-0.0028319876,0.07900145,-0.015111639,-0.054441758,-0.0051616468,-0.01203097,-0.111429304,-0.023656057,0.03416796,-0.11080829,0.012380948,0.054485746,0.09742213,-0.014455686,-0.09115944,-0.00021604235,0.0022027714,-5.40615e-33,0.0737751,-0.053656254,0.08740619,-0.08381906,-0.15692344,0.052638073,0.05002422,-0.12577945,0.04869529,-0.011589548,0.038229153,0.033881694,-0.0013728125,-0.044629596,-0.0112266075,-0.037372764,-0.033042118,0.092426494,0.073408835,0.0024344618,-0.0075026806,0.08036186,-0.0090690125,0.066167384,0.037097704,0.0104144355,-0.054141868,-0.0021887138,0.02808184,-0.00011568838,-0.029790228,-0.018193627,-0.025423428,-0.06816452,-0.0063862805,0.036417507,-0.077672526,-0.023634464,0.006892338,0.045562994,-0.036040686,0.10207761,0.020092348,0.10325001,-0.0545109,-0.0014635597,-0.020878164,0.030759284,-0.07040027,-0.0038640175,-0.019098466,-0.016976573,-0.04044668,0.0036946703,0.11189951,0.041760467,0.008124498,-0.04050281,-0.016627455,0.021724895,-0.03620841,-0.058203146,-0.017146597,0.001995658,-0.0012776675,0.041614953,-0.0060834535,0.043413546,0.027653558,0.008017045,-0.008101558,0.045306854,0.07423884,-0.024565492,-0.081763566,-0.020773781,-0.0075835767,0.00062339817,0.017947871,-0.063169554,-0.027631504,0.0680018,-0.10445271,-0.10370967,-0.021411391,0.00799202,0.062080633,0.09164918,0.009082051,0.02988502,-0.031067377,-0.05140579,-0.0601054,-0.021818902,0.028574603,-5.0150156e-08,-0.0036378016,-0.0673898,0.015540692,-0.083493106,-0.03106512,0.034872957,-0.019666968,-0.0020583486,0.06798485,0.036041196,0.040309742,0.055738185,0.02988812,-0.03079943,0.0657333,0.035174903,-0.008727227,0.012406419,-0.05514853,-0.053495515,-0.08139123,-0.01170784,-0.16011964,0.05271682,0.05151695,0.009376178,0.016204387,0.09981585,-0.026141198,-0.030931432,0.07256854,-0.02531869,0.008739292,-0.061145816,0.0031428093,0.08218689,0.049420346,0.0017697461,-0.07930567,0.043326,-0.10526583,-0.10089261,-0.010698869,0.011788443,-0.10303165,0.0070656654,-0.013880082,0.049384966,-0.004920883,-0.011658206,0.024153419,-0.021919416,-0.048651643,-0.058717076,-0.051303495,0.0264279,-0.0034043528,-0.056447007,-0.053631492,-0.00727818,0.012391154,0.0024206208,0.059056092,-0.09212847 +3.6.1.61,"The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5'-guanosyl) tetraphosphate very slowly [cf. EC 3.6.1.17, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)]. 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The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ [5]. ,384,1.0,-0.02696192,-0.08966874,-0.016313586,-0.010981368,-0.006421773,-0.016216883,0.039020922,-0.0023850612,0.009660194,0.03033721,0.03286582,0.01697304,0.022409214,0.0435166,-0.032389928,-0.03254047,-0.08830108,-0.018895851,-0.00637293,0.023517592,0.05315185,0.084048636,-0.054267943,-0.048502296,0.11219804,0.09210614,0.015663078,-0.029288284,0.04361288,-0.061524402,-0.019298557,-0.037914008,0.10719139,0.020225704,-0.00531968,0.05346317,-0.100061856,-0.019124648,0.014365139,0.06995266,0.015901757,0.048116524,0.036899153,0.024800915,0.05185253,-0.01504393,-0.007729148,-0.009419504,0.02669616,0.05292027,0.013293804,-0.04579078,-0.045537155,0.039366823,-0.087227345,0.012517046,-0.02786555,0.029336667,-0.02624952,-0.02802822,-0.029556684,-0.009015485,-0.040124163,0.0007189098,0.1390749,-0.04229978,0.026791137,0.05135694,-0.029537724,0.035973288,0.030339696,0.005072096,-0.07394992,0.034135226,-0.05622192,0.08117813,0.00082137063,-0.008867681,0.073545255,0.041792445,0.01860462,-0.03553649,0.12817657,0.06094715,-0.04660737,0.06377033,-0.0023117266,-0.01758844,0.005587354,0.053186446,0.059666224,0.04624576,-0.0028304644,0.11284939,-0.03578126,0.01876904,-0.00488892,0.09011041,-0.0038032865,0.0031256615,-0.0007372341,0.00016385892,-0.0724029,-0.08607788,0.014456288,-0.0320092,0.029421698,-0.005705918,-0.03367864,0.02380177,-0.02037773,0.03255263,0.025022974,0.025835814,0.07849008,0.0831148,0.025935978,-0.09489613,-0.010704015,-0.08768601,0.009213514,-0.017615456,-0.013419264,0.008058832,-0.10137768,0.04217639,-0.049928613,8.507068e-34,-0.0080819335,-0.08714875,-0.0032164336,0.07458631,-0.037023723,0.031698123,-0.08117592,-0.016636427,-0.08400532,-0.055491157,-0.05152445,-0.07249072,0.012214381,0.030777615,0.0007510687,-0.09788788,0.037010543,0.031554695,0.010591677,-0.00084748236,0.1111532,0.047768433,-0.00521338,-0.029119033,-0.021170266,0.06478576,-0.04266964,-0.033840846,0.00941804,0.0035859607,-0.051388517,-0.03723308,-0.061287336,0.022097906,0.040836338,-0.01695273,-0.03555826,-0.043627553,-0.059615087,0.023339368,0.043996133,0.002349298,-0.052142706,-0.03835664,0.06679215,-0.035022452,-0.080902465,-0.0061401674,-0.10837809,0.027609833,0.104519084,0.038802616,-0.007447917,-0.061984945,-0.043454763,0.04802928,0.011518555,0.012179456,-0.009895762,0.03557351,-0.021805253,0.013037189,0.018394565,0.07811956,0.04534281,0.06796773,-0.08585804,-0.04294324,0.0042731003,0.13127565,-0.029824486,-0.06833289,0.027032513,-0.026890473,-0.04503943,-0.0068822564,-0.028578881,0.0059069917,0.006276848,0.049888078,-0.01042188,-0.04217502,-0.019963054,-0.060208235,0.0100105675,-0.10152446,0.009848209,-0.08826421,-0.016914206,0.08195773,0.036375184,0.062113874,-0.008512019,0.027894333,0.045787908,-2.5115377e-33,0.03207739,-0.018159594,-0.009307586,0.011035623,-0.12795676,0.071348086,0.039810866,-0.06969634,-0.0048242207,-0.021873245,-0.025861764,0.0041797226,0.042730257,-0.01643886,-0.030594625,-0.022472722,0.05828794,0.086670406,-0.009162105,-0.044064183,0.006611548,0.025729042,0.0213265,-0.028304078,0.05744093,-0.03862992,0.023806622,0.08959903,0.0043532513,-0.010354709,-0.044226762,0.019756472,-0.006936416,-0.0348151,-0.09421191,-0.0023229152,0.028601417,-0.030274536,0.11085472,-0.031692218,-0.010850382,0.041877005,0.010748701,0.0705953,0.020744026,-0.018079516,-0.010350567,0.0035980286,0.057736274,-0.061035242,0.05246646,-0.07310546,0.033145662,0.055634357,0.011783154,-0.025606018,0.0011547179,0.0074213655,0.0650306,-0.0030429098,-0.020261265,-0.08944911,-0.031160576,-0.09553331,0.065458,-0.023696067,0.011644576,0.036315635,0.0037383162,-0.13864833,0.120134704,0.0022594307,0.02690038,0.0182223,-0.007756024,-0.06274128,-0.019731503,-0.017564556,0.017926307,-0.09591237,-0.097879626,-0.0039468124,-0.013097041,0.018460872,0.07091771,-0.06716736,-0.01076199,0.024601365,-0.0061658313,0.07217539,-0.05083627,-0.10110258,0.04636846,0.0482767,-0.025932094,-3.466326e-08,-0.031667266,-0.047114685,0.004871472,-0.03127346,0.049431987,0.088053554,-0.07838142,-0.02217111,0.09549627,0.014618159,0.07238795,-0.015943047,-0.10753304,0.05115446,0.055554345,0.057416584,-0.09705435,0.036001727,-0.013156267,0.007712047,-0.032133654,-0.015454422,-0.10411877,0.079092845,-0.05044067,-0.022702567,0.047254864,0.11496498,0.026155658,-0.11859977,-0.073056,0.03781187,0.05601015,-0.09087811,-0.11062943,0.024245374,0.08281096,-0.023103947,0.04949656,0.01700605,0.020717232,-0.026194159,0.02978969,-0.038402885,-0.11874397,-0.005438224,0.053615227,0.034519866,-0.03955486,-0.012522074,0.06184152,0.00018997758,-0.005506368,-0.019295666,-0.014296598,0.029079871,-0.012890065,-0.022101913,-0.01366312,0.03154147,-0.058569755,-0.009086111,0.10884923,-0.08314756 +3.7.1.17,"The enzyme is involved in the bacterial degradation of the steroid ring structure, and is involved in degradation of multiple steroids, such as testosterone [1], cholesterol [2], and sitosterol. 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+4.2.3.94,One of five sesquiterpenoid synthases in Pogostemon cablin (patchouli).,384,1.0,-0.058811016,-0.04332234,-0.10616795,0.029601356,-0.024437755,-0.00026736525,-0.03108912,0.051227834,0.063378215,-0.03817913,0.020827794,-0.05927218,-0.07239088,-0.036385957,-0.049268343,0.025352465,-0.04683035,0.0634832,0.076219246,-0.039502926,-0.016383559,0.004355002,0.0070773265,0.06030058,0.040265426,-0.06598408,-0.07095265,0.010933641,0.023134075,-0.09545266,-0.07168049,0.025122864,0.085942686,-0.014955406,0.02906336,0.029291525,0.03929366,-0.06791476,0.05336442,0.040570863,0.086202465,0.045159306,0.0313462,-0.11655775,-0.06337655,-0.04685452,0.0077905552,0.0017607566,0.021973953,0.012363114,-0.032438483,-0.112497754,-0.05729924,-0.03951579,-0.018628301,-0.07879894,-0.0054835803,0.0031520275,0.007572225,0.043813128,0.024306351,0.038628634,-0.016423866,-0.032929216,-0.085171856,-0.02189302,0.011183233,0.014804853,-0.0054441453,-0.025550464,-0.034715302,-0.028514246,-0.054296214,-0.030231591,-0.07611032,0.11049388,-0.0068955543,-0.05724144,-0.004226125,0.007110629,0.029110039,0.051253174,-0.006024453,0.028238494,-0.027810277,0.016717333,0.014119319,0.056900438,0.013282645,0.035596143,0.075857304,0.0010335143,0.0066974736,0.0014708686,-0.050972074,0.05538775,0.046529327,0.07071176,-0.0341856,-0.042330746,0.0037810337,0.029759383,-0.014323569,-0.06897658,0.011277688,0.02192861,-0.020875014,-0.022796892,0.029590769,-0.0712147,-0.005560263,0.022574889,0.03349868,-0.009504121,-0.025494084,0.022931064,-0.018797804,-0.015520204,-0.0060170135,0.11694609,0.008977772,0.003213082,-0.018296227,0.028695337,-0.00079311884,-0.032593027,-0.0007017121,3.6354686e-34,0.092848755,0.07360913,0.085601926,0.03307808,0.036273398,-0.028826298,-0.07653059,0.034992605,-0.06044914,-0.028619792,-0.14269131,-0.08996694,-0.00910231,0.09375773,0.010142166,-0.028258368,0.003955974,-0.044707347,0.016219854,-0.021588922,0.02141707,-0.012248306,-0.08788282,-0.095785476,-0.0062613827,0.089672714,0.0047078575,-0.005644906,0.03479693,-0.018761637,0.00935923,-0.040675372,-0.011822641,0.026364993,0.06828603,-0.089513905,0.088138916,-0.062115826,-0.04282941,0.015509437,0.008580859,-0.029651899,-0.07873675,-0.025252338,0.082957186,-0.07881227,-0.007480847,0.054855447,0.10062861,0.03770816,-0.022919564,0.005318072,0.044839922,0.015553642,-0.055117246,-0.017972179,-0.022507396,-0.0691401,0.030556526,0.08061385,0.028168289,-0.009859291,-0.00047647086,-0.063440755,0.041083477,0.092622094,-0.05684334,-0.060157403,-0.0028482436,0.05652832,-0.013918479,-0.08219119,-0.07485712,-0.032376606,0.06339321,0.0056355353,-0.08901155,0.073325716,0.038126383,0.02715054,-0.041605975,0.013243429,-0.04703089,-0.00951123,-0.0399988,-0.0069132186,0.05372857,0.11162016,0.01334497,0.096147075,0.013217775,-0.04717975,-0.024727723,-0.046104297,0.01406391,-1.2264368e-33,0.0057762126,-0.09955944,-0.015486017,-0.08714429,-0.09207242,0.04236444,-0.021885006,0.039742827,0.068132624,0.05331668,0.009771502,0.014422773,0.068685114,-0.069334105,-0.0872474,-0.012101039,-0.0072711967,0.07350295,-0.006196126,-0.04091973,-0.06636303,0.006015388,0.034342863,0.09499292,0.02423149,0.013912966,0.01092632,-0.033794157,-0.045508098,0.13690169,0.028820613,-0.0489091,-0.010804587,0.051561657,-0.020244969,0.055876598,-0.00083459937,0.00689855,0.0037016817,0.04961036,-0.04289816,-0.012748458,0.045345884,0.08675674,0.11931864,0.016441118,-0.1261445,0.028616894,-0.059423354,-0.008524278,0.03984156,0.054380026,0.052851375,-0.027956527,0.0454985,-0.032836895,-0.05045885,-0.025475575,-0.012716261,-0.055616338,-0.054304995,-0.0691174,-0.05439239,-0.013512971,0.073630475,0.081378676,-0.02044692,0.024724483,0.09075707,-0.02268328,0.052874636,0.057936776,-0.0069802203,-0.062068425,-0.03104876,0.010751459,-0.013109694,-0.05305277,0.0728438,0.017700164,-0.053111706,-0.059113737,0.011974862,-0.0711501,-0.09504987,-0.040088516,0.059793394,0.10579287,0.027913034,0.057423167,0.00047186806,0.006767267,-0.038535308,0.05816971,0.046402693,-2.1537064e-08,0.06970663,0.0086981775,-0.011033398,0.07238805,-0.032567542,-0.0050319075,-0.02236407,-0.009116833,0.03504876,0.060333546,0.028031379,0.020978898,0.038498554,0.005104954,0.0836091,-0.021912146,0.027408442,0.03669212,0.004355345,0.11055659,-0.005326416,0.034519915,-0.057544786,0.013502793,0.052167512,-0.08664701,0.0697103,0.018902896,0.015583962,0.06228167,0.09965189,-0.028819501,-0.06864893,0.012756345,-0.02893665,0.004226123,-0.010064915,-0.044669207,0.033957742,-0.0032410016,-0.010440559,-0.089790106,-0.05144878,-0.018023672,-0.097217724,0.03623857,0.03682437,-0.03711484,-0.005131778,0.02430251,0.08121922,-0.0043054856,0.037991483,-0.027002187,-0.08730124,-0.0017566453,0.0447349,-0.025693165,-0.07802034,-0.046371065,-0.06875456,0.045091394,0.16834684,0.035265654 +4.2.3.95,The enzyme from the fungus Coprinopsis cinerea produces (-)-alpha-cuprenene with high selectivity.,384,0.99999994,-0.014064937,-0.056869417,-0.053301156,-0.008887722,0.10524848,0.02767977,0.016867613,0.015233532,0.0756609,0.021499302,0.051725388,-0.095235534,-0.13377407,0.027201837,-0.052211985,-0.013178124,-0.02424706,-0.020486262,0.037930433,-0.027628204,0.0017608345,-0.029899234,0.017123658,0.04880195,0.0038075934,-0.0101405615,-0.007936637,-0.07600043,-0.0065378663,-0.056123346,0.01639032,-0.012195553,0.069732316,0.038629014,-0.057310916,0.05498448,-0.014738253,-0.08453118,0.02506578,0.0331647,0.0131812645,-0.03072411,-0.025577383,-0.034923982,-0.08145973,0.009319492,-0.007451467,0.052547447,0.059714783,-0.02571029,-0.0038886515,0.0010033477,0.026254019,-0.0691833,-0.0012171153,0.09454299,0.019407893,-0.033943743,-0.010893873,0.030075597,0.031425368,-0.006251994,-0.0416848,0.0015972882,-0.019541495,-0.03850059,-0.02368002,0.070392355,0.051229738,-0.02069057,-0.018345598,-0.012203211,-0.032200485,-0.061976332,0.017285822,0.115833275,0.0039233677,-0.042273737,0.06404629,0.015416917,0.018295234,0.053146407,0.018261513,0.06679276,0.04254179,0.058791947,0.042040996,-0.029371021,0.039285038,0.030018706,0.036540437,0.09303179,0.0017816414,0.010661911,-0.076071955,0.07900206,0.049402583,0.025023056,0.029239064,-0.036409073,0.033383064,0.016263451,-0.024514662,-0.068414025,-0.09677155,-0.0015321387,0.01604275,0.027484475,0.091227196,0.09976463,-0.0004323558,0.0032985224,-0.021627432,-0.016716832,0.0036078652,0.09407843,-0.03311656,-0.017096745,0.030985555,-0.029450027,-0.051834323,-0.008125372,-0.07868274,-0.010258021,-0.10499792,0.057695586,-0.00042158426,-1.3382508e-33,0.03941632,0.04078056,0.0060514575,-0.012359381,0.022816941,0.018359536,-0.09509658,0.012271119,-0.10615201,-0.07320131,-0.095965914,-0.07469351,-0.06925667,0.03644651,0.018216603,-0.08890029,0.029475166,-0.013677135,0.05125632,0.05402006,0.024055064,0.03486429,-0.10529764,0.016761256,0.034010056,-0.04478904,-0.03913975,0.021377007,-0.0064075654,-0.06335748,-0.014679864,0.0020896974,-0.0028562802,0.040494654,0.010287689,-0.013841488,-0.039983056,-0.006449893,-0.03179269,0.015943939,0.013777442,0.012061883,0.014711669,0.025738923,0.04471303,0.012055265,-0.018349253,0.014742374,0.0056271474,-0.03549612,-0.0034997205,0.08577077,0.079375505,0.02084971,-0.0023534219,0.053818755,-0.06811505,-0.0069068023,0.045611583,-0.018944524,-0.04363721,0.1348339,-0.0047386847,0.05651346,-0.014361788,0.06566808,-0.085704565,0.017789587,0.041179944,0.07212339,-0.022097237,0.026441246,-0.03847575,-0.083841905,0.13014984,0.01777597,-0.09701921,-0.017383855,0.0037817145,-0.013824531,-0.032575626,-0.037084755,-0.0112767825,-0.029257348,-0.09326455,-0.0044978904,-0.0523186,0.046210136,0.09457562,0.028198743,0.06401839,-0.092746645,-0.022489449,0.0152407205,-0.039648034,5.563969e-34,0.11346299,-0.15096729,0.06862854,-0.048646662,-0.04204413,0.12733819,-0.031341124,-0.07775747,-0.015608483,-0.024874223,0.027712222,0.022734268,-0.007417847,-0.08425178,-0.022240104,0.049250696,0.0032793004,0.10619968,0.008466371,0.017569453,-0.028203823,0.032050975,-0.042740967,0.013739206,0.069658965,-0.006153476,0.082320385,0.06605637,0.0479187,-0.039279975,0.07375509,-0.016545895,0.031387806,0.0028647797,-0.056197826,-0.007116809,-0.017822867,-0.012547156,0.022145588,0.04754428,-0.077054456,-0.026191143,0.0029066592,0.08789385,0.087880455,0.0074232477,-0.09117714,-0.0040283506,-0.041659776,0.013514532,-0.009464967,-0.0009883338,-0.0039492347,-0.000582261,0.021111654,0.02735306,-0.010069998,0.0034231644,0.015582298,-0.018868804,-0.01026046,-0.033688497,-0.043544665,0.017671745,0.05840553,-0.015931137,-0.042839773,0.11672273,0.038613696,-0.02047681,0.081469044,0.090518355,0.044012416,0.10023973,0.027610552,-0.007199141,0.06455901,-0.03648739,-0.0040319962,0.023276012,-0.016058732,0.004940611,0.0485278,-0.087440535,-0.030153433,-0.06244191,0.09561194,-0.012159748,-0.043872736,0.060083926,0.0022729803,-0.015607402,-0.033108216,-0.013167478,0.13137054,-2.4607015e-08,0.027481167,-0.031785544,0.01114603,-0.10286812,-0.032083437,-0.034694854,0.07154954,-0.016355759,0.015163515,-0.04569522,-0.067916535,0.042731278,0.06142868,-0.019597683,0.09408694,-0.05345968,0.05594966,0.0011473933,-0.028048784,0.010874823,-0.04054793,-0.0019761955,-0.12206693,-0.0064444626,-0.06809693,-0.06250228,0.056855917,0.035861988,-0.021148978,0.040613614,-0.04686728,0.018216806,0.04687224,-0.025879785,0.050715625,0.07401517,-0.054576237,-0.12086965,-0.020147126,-0.06396124,0.03842389,-0.06885461,-0.020758223,-0.023019891,-0.054907937,-0.067946635,0.024361497,-0.004060001,0.06455777,0.08308476,0.09784244,0.052865457,-0.008522887,-0.017029239,-0.04186311,-0.051150277,-0.04234571,-0.014390401,-0.07436945,-0.08644417,0.030880252,-0.06513179,0.14382218,-0.021039722 +4.2.3.96,"Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained.",384,1.0,-0.064872295,-0.031801246,-0.05364856,0.04173936,0.03377841,-0.01116261,0.022365572,0.07074785,-0.004779281,-0.033165377,0.00017726676,-0.021948477,-0.032390714,0.047912925,-0.043964416,0.004855909,0.038516685,0.054044645,-0.006198615,-0.0283166,0.06515044,-0.054061756,0.04888103,-0.01728344,0.06970449,0.008709528,0.07424257,0.003838032,0.059146576,-0.07306503,0.02203285,-0.051152643,0.056352872,-0.13819604,0.0017902203,0.13658722,-0.035341457,-0.039248664,-0.02371363,0.0080213,0.013869009,-0.028507125,0.029163146,0.033234697,0.0014691106,-0.08724498,0.047747348,0.055429302,0.001294761,0.06410062,-0.028868267,-0.012976784,-0.05473274,-0.0016067505,-0.03219651,-0.017414734,-0.072344445,-0.0052667973,-0.024033839,0.032629557,-0.019538702,0.010100397,-0.07636147,-0.06387625,0.015544106,0.006078486,0.057775635,-0.08897562,0.098958425,0.02501898,-0.019292735,-0.025638536,-0.027638098,-0.018457493,-0.041225865,0.0007486333,0.020261677,-0.015336148,0.053729836,-0.009758119,-0.010144588,-0.017240431,0.052531816,0.1283936,0.08874105,0.029525047,-0.023005625,0.05804841,0.04847338,0.03950837,0.09025657,0.018929258,-0.0120840985,-0.05277616,0.03433162,0.041229155,-0.068821535,-0.051148754,-0.042515438,-0.0073018284,-0.011370782,0.057217084,-0.072151154,0.013856801,-0.07034343,0.026285557,-0.039362855,0.0028096419,0.0065297415,-0.0026413135,0.0203217,0.041020423,0.06998349,0.07562979,-0.013481232,0.036848977,0.00011843132,-0.113680534,-0.017128613,0.019056119,-0.040759504,0.015653297,-0.008198507,0.06624885,-0.045972,0.032047965,-0.03518494,9.231671e-33,0.00292797,0.056820486,0.029496172,0.073049776,-0.12451692,0.098108515,-0.07673125,0.029946607,-0.020152673,-0.009612654,-0.077169046,-0.09224188,0.00553777,0.028650701,-0.011264527,-0.070254296,0.045756742,-0.006223954,0.09059868,-0.059574384,-0.057454664,0.10263218,-0.035403643,0.015513722,0.04595245,0.13189453,0.05570434,-0.009937044,0.044318594,0.0046969294,0.08203341,-0.056797124,-0.045157406,0.013281257,-0.009442782,0.024920283,-0.06912668,-0.02152757,0.024425743,0.029045956,-0.048174195,0.06872993,-0.06152437,0.005400305,0.07534218,-0.121668875,0.005534109,0.082929,0.039876666,0.085153945,0.054269146,0.0027129282,-0.031942524,0.033195145,-0.1448738,0.03687367,-0.06561081,0.028002353,0.09441459,0.0071990243,0.026693113,0.053624433,0.041753843,0.03364791,0.055844434,0.04928142,-0.08567216,-0.06958163,-0.07003023,0.111211345,-0.019304352,-0.05944907,0.044573378,0.010934771,-0.034866232,-0.008651301,-0.013508577,-0.0104521485,0.085001096,-0.016210534,-0.006598435,-0.04599423,0.017760033,-0.015189401,-0.05695531,-0.08199344,-0.022057781,-0.06610975,0.026482165,0.08947793,0.021738363,-0.10704736,-0.034655444,0.035793148,0.021773297,-7.696793e-33,0.058096085,-0.06536889,0.06501,-0.029439526,-0.07971922,0.04174505,0.01784128,-0.15771773,0.037367314,0.031398784,0.027882071,-0.006442089,0.032222185,-0.028252594,-0.038040243,0.020265598,-0.027768828,0.06359709,0.009199346,-0.02443403,-0.002899403,0.08469635,0.080958,0.07599944,0.022918057,0.046576645,-0.006417273,0.031337485,0.031157432,0.026755285,-0.011665946,0.02177669,-0.03203177,-0.11162594,-0.045240507,0.0016536823,-0.0077370205,0.045098655,-0.009464888,0.04292279,-0.0076198727,0.047353312,0.049129065,0.04775118,0.047773972,0.05863043,-0.033534676,-0.034299098,0.035752073,-0.111530334,-0.0057604993,-0.020189935,-0.05137009,-0.009212597,0.026883055,0.0035006562,-0.0010881224,-0.032832254,0.042416874,-0.04083113,0.0005742923,-0.018472336,0.05363629,-0.06031605,0.035763383,0.033776466,0.06473681,0.10626731,0.03648103,0.055411223,0.085733294,0.054873362,0.14097661,0.0011280132,-0.026592493,0.08457605,0.004593533,-0.046310917,0.051868297,-0.15705469,0.0058275326,-0.0041792225,-0.05717154,-0.06654715,-0.06054809,-0.08985281,0.03416307,0.06976965,0.0116543695,0.013287031,-0.055801988,-0.03717806,-0.014000036,0.012229719,0.10441362,-4.4561673e-08,-0.022767175,-0.035352476,0.03796446,-0.03553114,-0.005298845,0.078506306,-0.030345427,0.027885905,-0.018669227,-0.05972902,-0.0008691031,0.009451674,-0.022596154,-8.614804e-05,0.009061624,-0.028823938,-0.03538192,0.031346828,-0.04930621,-0.060032472,-0.046638746,-0.010344,-0.05550895,-0.011076634,-0.02876403,-0.060161278,0.039784666,0.042831134,0.00554983,0.0024901698,0.059870392,-0.017011732,0.017370436,-0.028489452,-0.11042213,0.048460267,-0.004672181,0.009917954,-0.028782966,-0.05047437,-0.016446155,0.013225186,0.008536845,0.018595828,-0.049167734,-0.031452496,0.052011736,-0.025396792,-0.05788398,0.03583571,0.0129191475,-0.0428447,-0.076048754,-0.04429871,-0.058184985,-0.02241514,-0.018186193,-0.04763462,-0.02040547,-0.10616579,0.0039615873,-0.0024907815,0.035948206,-0.056822665 +4.2.3.97,"The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. Following a 1,3-hydride shift of the original 1-pro-S hydrogen of (2E,6E)-farnesyl diphosphate, cyclization and deprotonation gives (-)-delta-cadinene.",384,1.0,-0.018216886,0.09100021,-0.019054504,-0.07871825,0.06658736,0.017258067,0.033522632,0.089234605,0.027627792,-0.02002877,0.07913755,-0.042887256,-0.0031155408,-0.04677862,0.0002680226,-0.051922552,-0.07529804,0.03481905,0.006381059,-0.05591142,-0.025109962,-0.03497342,0.013612605,0.042408653,0.041476004,0.05636943,0.05983053,0.011376147,0.01617564,-0.0849548,0.07088958,0.036225386,-0.0063635022,-0.044738133,0.06615951,0.03730994,-0.047294788,0.042923935,0.0038476293,0.026164675,0.03225351,-0.021593366,0.030199993,-0.051474527,-0.09162692,-0.02883053,0.004217405,-0.015205832,-0.007615731,-0.040640365,0.05838008,-0.045567524,-0.008076339,-0.017402805,-0.046389706,0.045087297,-0.07931254,0.09711448,-0.012178325,-0.0983818,-0.025476962,0.06461587,0.0025506604,0.00079599133,-0.076102935,-0.10045223,0.04713987,-0.097359024,0.024706285,0.06414265,-0.047951095,-0.007276787,-0.057723634,-0.04689526,0.043196842,-0.0053149867,0.031587012,-0.037401658,0.08174434,-0.10089453,0.022981958,-0.0074838917,0.0020705978,0.0341971,0.011957719,0.015612972,-0.069145605,0.008976817,0.013025948,-0.07079479,0.022203708,-0.031136237,-0.066877246,-0.08883146,-0.06967698,0.0887702,0.016755605,0.04052642,0.08419212,0.059924487,0.07502224,-0.0029138322,-0.0639223,-0.07363289,0.025623603,0.03263097,-0.07142607,0.09610085,-0.036213472,-0.0071324473,-0.0035120216,-0.060981255,0.037481874,-0.008173608,-0.09289692,0.07643575,0.005247219,0.056789577,-0.00395289,-0.09354222,-0.009773882,0.018613443,-0.011595953,-0.006546006,-0.024604516,0.01654096,-0.057333127,2.9341698e-33,0.021955855,0.016351797,0.025325943,-0.009119365,-0.07311069,-0.109849244,-0.018268123,-0.013021995,-0.10006837,-0.029067127,-0.028306376,0.002397563,0.020238591,-0.023478683,-0.028251827,-0.025674991,-0.026872832,0.03955784,0.015081745,-0.078709945,-0.0219382,0.08418884,-0.015482758,0.032275382,0.015066154,0.02755677,0.044443216,-0.059581473,0.041605018,0.013783227,-0.058892354,-0.045515824,-0.01745284,-0.023432694,0.100762084,0.035698794,-0.05449067,-0.060550418,0.004803132,-0.017287252,0.0138025265,-0.04061273,-0.06000958,-0.05196508,0.04722225,-0.015274238,-0.03721557,0.056670137,0.018274626,0.028396543,0.07236388,-0.039423443,0.10425377,0.024680682,-0.056201063,0.03409815,0.012200903,-0.029849939,-0.0022907332,0.012585232,-0.011861537,0.025839385,-0.05971495,0.031936318,0.074517876,0.04921589,-0.07286826,0.025377015,-0.09029015,0.07640534,-0.02423363,-0.026041254,0.03647539,0.07835609,0.036386218,0.09266561,-0.0659909,-0.035355926,0.035280593,0.013710304,-0.032119535,0.044348873,0.032976832,0.02883544,-0.051641803,-0.08527874,-0.027640212,0.0048361374,0.0011930632,0.085341215,0.068020426,-0.11434868,0.001991162,0.032249443,-0.046083994,-4.428973e-33,-0.05285673,0.061499212,-0.04094765,-0.06150483,0.017169656,0.018690808,0.09329186,0.011734448,-0.10087437,-0.07927788,0.0181668,-0.018337572,-0.06349075,-0.07379037,-0.044217907,-0.029585639,0.05109805,0.12334963,-0.005424768,0.055508085,0.013521761,0.025354877,0.015295371,0.08732103,-0.011038734,-0.030961348,0.050188623,0.0845493,0.0371702,0.08961685,0.007974798,-0.009315506,0.015873477,-0.050082117,-0.009536184,0.07412971,-0.077089086,0.02624272,-0.021240138,0.011497463,-0.068221256,-0.110932305,0.029873341,0.049775865,0.14238754,0.099562705,-0.044330373,0.028782213,-0.041021544,0.0114737125,-0.036585543,0.018447662,0.021873306,0.010552638,-0.016376827,0.04049074,0.039984055,0.026457492,0.082842216,-0.056992404,-0.04247379,-0.049514912,0.015554553,0.03638711,0.048834536,-0.010750838,0.018654047,-0.017996814,0.00090521114,-0.07324964,0.14251623,0.04766952,0.015230382,-0.009264155,-0.018415218,-0.052647736,0.03666093,-0.082565404,0.05730721,-0.02475618,-0.015148317,-0.015038094,0.03941873,-0.025859483,0.044790052,-0.05437102,-0.030721707,0.06287852,-0.0036835747,-0.0072395913,0.021264862,0.046096314,-0.034231357,0.10785999,0.061233208,-4.448835e-08,0.09391837,-0.04000359,-0.006866368,-0.007691647,-0.0041878596,0.06417244,0.03607928,0.05496976,-0.015162839,-0.09045719,0.007817622,0.029490653,0.08666009,-0.0424651,0.04929416,0.04563137,-0.0050084675,0.043148804,-0.05999531,-0.07604949,-0.057841007,0.002455574,-0.020646637,-0.03997522,-0.018948946,-0.032436136,0.032979928,0.0587977,-0.045706615,-0.066287406,0.054802902,0.0065337135,-0.038307484,0.10953131,0.038977016,0.022031799,-0.06715084,0.038819913,0.055584814,-0.019899223,-0.05331193,0.06232603,-0.08446129,0.057207037,0.015400767,0.038599346,-0.0048886947,0.03458473,-0.04328304,0.018333102,-0.017573778,-0.029155994,-0.026714223,-0.12071487,-0.072120644,-0.02044744,-0.015308102,0.018061256,-0.053293884,-0.090608865,-0.03726605,0.010787189,0.11513182,0.0074357544 +4.2.3.98,"The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol.",384,0.99999994,-0.061479602,0.074790016,0.02525966,-0.05942403,0.07772975,-0.013129828,0.035397176,0.10939481,0.076168254,0.00017385135,0.07124137,-0.039868116,0.039796986,-0.009159404,-0.063433245,0.024660971,-0.06919327,0.034284208,0.047161486,-0.06427878,-0.001477273,-0.02891468,0.03949071,0.061264653,0.029104773,0.051918156,0.012604409,0.042879164,0.0071034497,-0.044264615,0.03233675,0.05328347,0.0050450014,-0.044274427,0.017025888,0.04782196,-0.087554336,0.040494464,0.01927682,0.04418614,0.028250394,-0.04241553,-0.016916364,-0.020302368,-0.109334044,-0.009664983,0.042826273,-0.042144466,-0.043893337,-0.02856381,0.017285485,-0.038198505,-0.024119759,-0.0072269035,-0.038033817,0.052842557,-0.11783347,0.11911676,-0.033610374,-0.082544506,-0.051256895,0.05468431,0.003904478,-0.008958806,-0.048048396,-0.05345626,0.0043904595,-0.07940757,0.028859844,0.037988577,-0.03403619,-0.043368485,-0.020582372,-0.06438075,-0.0033963288,0.034905612,0.04603707,-0.031719733,0.044063944,-0.092007674,0.026367592,-0.0009734968,-0.036142953,-0.0043337974,0.06011211,0.025685573,-0.0567685,0.026509661,-0.026025413,-0.018825857,0.02077345,-0.05533801,-0.08805747,-0.05797344,-0.020523092,0.07381517,-0.005115423,0.022705903,0.023534548,0.05347017,0.0208359,0.015218378,-0.009818947,-0.08379729,0.0023323246,0.02040572,-0.02745769,0.036279052,-0.04497357,-0.06416719,-0.018080655,-0.02352427,0.036609653,0.016257534,-0.06336461,0.07335995,-0.010206382,0.084310114,0.016515834,-0.08706728,0.007050764,-0.016394667,-0.059480645,0.019085418,-0.035805162,0.034289062,-0.050538346,3.764889e-33,0.028040446,-0.01348713,-0.03081086,0.038048495,-0.07876505,-0.07527993,-0.006747849,0.000603535,-0.09354619,0.0004853884,-0.033131566,-0.043791708,0.033564385,0.014287976,-0.06806802,-0.058051918,-0.029983785,0.034253184,0.048815675,-0.09155508,-0.04243126,0.087410904,-0.029743847,0.0033472797,0.0070226574,0.051623404,-0.0221646,-0.08200211,0.09598633,0.02850192,-0.064430006,-0.06843737,-0.073407225,-0.005395812,0.044868805,0.048471715,-0.058322836,-0.056134917,0.033143666,0.02422476,-0.02440456,-0.061707735,-0.07310703,-0.05882731,0.06133249,-0.00541119,-0.04247528,0.08321407,0.0008553229,0.013901478,0.08933778,-0.05563853,0.06214228,0.020667147,-0.07973476,0.042468682,0.010530764,-0.055124078,-0.018944966,0.031056605,0.0026136732,0.00011781438,-0.04546246,-0.016718946,0.094820134,0.039422885,-0.11013013,0.012094029,-0.086177476,0.107728675,0.041437175,-0.00492167,0.0170747,0.086081445,0.028320568,0.07791109,-0.047273036,-0.020854793,0.021910116,0.035221275,-0.020329712,0.045875937,0.022163287,0.011249674,-0.041892245,-0.005461105,0.0039281063,-0.022353852,0.014929234,0.086710766,0.03016747,-0.124702804,-0.019139312,0.015071273,-0.0506674,-3.7245465e-33,-0.034700196,0.010590022,-0.026760938,-0.03229792,-0.042344447,0.051106937,0.035540856,-0.007701466,-0.10370802,-0.029245177,0.044733163,-0.03384432,-0.0989488,-0.10181096,-0.03010849,-0.048810225,0.020814085,0.108764775,-0.009833825,0.033923022,0.03794242,0.04813197,0.043172155,0.06837724,-0.0056893453,-0.004154063,0.0037265364,0.095424406,0.04597501,0.112978406,-0.05481039,-0.0059203645,0.009963785,-0.038544625,0.015446744,0.11569791,-0.07910652,0.032772973,-0.010833241,0.012364533,-0.058045276,-0.07634408,0.056162126,0.064974524,0.1168516,0.12340733,-0.049119852,0.009633822,0.021508303,-0.0271245,0.002009029,0.0647198,0.05100945,-0.029666984,-0.017755358,0.07191733,0.006358625,-0.004735989,0.06107285,-0.113718726,-0.038950194,-0.07276767,0.009608632,-0.003256037,0.07657589,0.039584585,0.01545497,0.008802732,0.015709413,-0.05413979,0.11330709,0.039069932,0.014878783,-0.03443665,0.0039019699,-0.022862406,0.016735312,-0.042118214,0.060171787,-0.038262695,-0.016468436,0.0021747828,0.002308143,-0.06711166,0.037591003,-0.023311947,-0.02780823,0.07529215,0.015996227,-0.012444678,0.025539719,0.09738097,-0.014218335,0.12295504,0.087768055,-4.1490214e-08,0.06937681,-0.054013893,-0.021983314,0.03157788,0.03625665,0.07471511,0.022836136,0.049458586,-0.019915082,-0.07393251,-0.03128833,0.023886481,0.08153657,0.0030774586,0.07360196,0.06867254,-0.033035826,0.01186432,-0.021016303,-0.088334315,-0.03902836,0.010992939,-0.032007527,0.0034514922,0.004069176,-0.027027268,0.042241137,0.058431614,-0.038313914,-0.02136602,0.07513802,0.0043053455,-0.05674641,0.105665565,0.048193753,0.020283936,-0.086897135,0.035726387,0.0076464904,-0.009370639,-0.08864392,0.06767162,-0.0497775,0.060792837,0.00030717556,0.008470182,-0.016519178,0.04602284,-0.033139538,0.021283971,0.016820801,0.000528996,-0.013087566,-0.07173283,-0.095401734,-0.025736198,0.031656224,-0.0040648826,-0.029286535,-0.097753,-0.09053853,0.01151207,0.09503203,-0.006502786 +4.2.3.99,"The enzyme from rice (Oryza sativa), expressed in Escherichia coli, also produces ent-sandaracopimara-8(14),15-diene from ent-copalyl diphosphate, another naturally occuring copalyl isomer in rice (cf. ent-sandaracopimaradiene synthase, EC 4.2.3.29).",384,0.99999994,-0.09661303,-0.050353173,-0.058031365,0.016195362,0.027266748,0.069312766,-0.07458157,-0.010142219,0.04664785,-0.01756083,0.13212623,-0.025991425,-0.03741999,0.017273389,-0.033367284,0.012255528,0.0065719415,0.076593176,-0.041732166,-0.10125699,0.10093808,0.041530352,-0.047314532,0.0074262996,0.04344304,-0.043532897,0.029225266,-0.04095318,-0.009963348,-0.094695665,-0.052448742,-0.02098112,0.018543132,-0.07004394,0.1367486,-0.030620005,-0.016093217,-0.108683184,0.11091354,-0.048513122,0.032538056,-0.031057203,-0.021510594,-0.086101875,-0.018720888,-0.07011755,0.011392345,-0.018807396,0.069189824,-0.033209387,-0.078369014,0.012070454,-0.055660643,-0.016176365,0.023634285,-0.0365012,0.052802436,-0.014202431,-0.073986575,0.05572849,0.027560696,0.023187108,-0.028415987,-0.037783623,-0.06880058,-0.020667845,0.03341444,0.008740976,0.05982292,-0.049472533,-0.07226849,-0.075004056,0.0002788466,0.097662784,-0.022378497,0.021484163,0.0070569254,-0.016947752,0.04716025,-0.031565756,0.016933555,-0.0026899567,0.024892308,0.012618256,-0.00063159986,-0.017422361,-0.0042245258,0.109422065,0.12723142,-0.017363375,0.008527924,-0.016702969,-0.042094722,-0.021639422,0.023984574,0.02945735,-0.032817956,0.01204361,-0.03067547,-0.047281872,0.020049281,0.08064934,-0.0840018,-0.11809994,-0.009249439,0.052132674,0.03684677,0.019853696,-0.009019661,0.03185015,-0.0066906437,-0.027444385,0.043686427,-0.013821125,-0.05711375,0.056325633,-0.029010767,-0.06616039,-0.0069475328,-0.042521082,0.053544734,-0.04727313,-0.0032273096,0.09782604,-0.014229886,0.05536058,-0.06739281,2.3221737e-33,0.09687884,0.045479637,0.073163606,0.0040509487,-0.008972513,-0.046813276,0.0062217526,0.018206466,-0.020275593,-0.0852923,-0.095426954,-0.13154319,-0.035043914,0.056230225,-0.002358863,-0.0049549947,-0.013041212,-0.04945825,0.00083945406,0.016096827,-0.05739963,0.09206427,-0.07287122,-0.02617504,0.011649812,0.010507509,-0.036706172,-0.0026305695,0.049289603,-0.01579933,0.0634242,-0.0528476,-0.053290766,0.029577494,0.080423206,-0.045507118,0.024609413,0.0038178016,-0.037534557,0.100052774,0.09079099,0.06447999,-0.00078632735,-0.0065518245,0.0566246,0.024456952,-0.050266773,0.10605553,0.05040718,0.009664274,-0.0004183451,0.04160412,-0.0033051178,-0.027796919,-0.019413186,0.018289592,0.040765207,-0.028788649,0.030107336,0.06349431,-0.09153814,-0.004641803,5.937501e-05,0.050281122,0.002124478,0.05181996,-0.07668111,-0.04369268,0.005921228,0.05418247,-0.065641776,-0.029186742,-0.059954155,0.007988307,-0.02674633,-0.110109605,-0.05779853,0.017705446,0.0062303017,-0.0011055705,0.001011126,0.014721332,0.0066141738,0.0034163417,-0.09098358,0.023890244,-0.078571066,0.03809637,0.044376213,0.042507645,0.08615667,0.0032678836,-0.0055635264,0.092129774,-0.0291869,-4.094188e-33,0.053002823,-0.06891021,0.05660257,-0.11018706,-0.13869421,0.030008549,-0.022629634,0.008696132,0.08282905,0.070333555,0.036234472,-0.042684957,0.105981715,-0.057407297,-0.035094358,0.02743431,0.039775163,0.07776406,-0.023036834,0.042726215,-0.02224205,0.07523479,0.074911445,-0.023328846,0.05210089,0.021910632,0.010542142,0.071268894,-0.07924085,0.05225324,0.06273004,-0.07905106,-0.03487339,-0.048247695,-0.050526243,0.026893098,4.0449846e-05,-0.041143086,-0.032524657,0.011896356,-0.052860662,0.04835009,0.021463763,0.035482135,0.0037430217,-0.033358514,-0.04226299,-0.04947536,-0.027144976,-0.059949253,0.013635161,-0.035707384,0.03477024,-0.027896428,-0.029129913,0.020980634,-0.02442131,0.053045824,-0.022006445,-0.045898817,0.03335299,-0.030752154,0.0028303128,-0.06833478,0.074277475,0.08415822,-0.017719695,0.024802195,0.028388444,-0.029333645,-0.007195498,-0.02624723,-0.030677687,0.08755214,-0.026904501,-0.017272169,-0.07342219,-0.029676652,-0.017757038,0.02388657,-0.061503332,-0.035775278,-0.04872066,-0.07296603,-0.051799152,-0.023454746,0.04373457,0.13384515,0.06746567,0.09070845,-0.021973899,-0.026529552,-0.042419706,0.098264195,0.03413407,-4.0281304e-08,0.044365216,-0.1405879,-0.008859439,0.01404003,-0.09956041,-0.0056541315,0.037196875,-0.004974471,0.07962976,0.006517105,-0.05182258,0.078400694,-0.009179978,0.020926347,0.0022987502,0.008953426,0.015049771,0.10848019,0.018543897,-0.029314728,-0.026888818,-0.009971247,-0.028819997,0.0056917747,0.021773618,0.003770604,0.01292632,0.034975946,0.05508465,-0.010847955,-0.031007357,-0.053991422,0.019017871,-0.08553865,-0.03408063,0.064233385,0.019956833,-0.03219787,0.018791886,0.023457732,0.0035372295,-0.013000068,-0.055887815,-0.008147023,0.061046068,-0.0010944052,0.026862323,-0.011363818,0.017260836,-0.03139704,0.034444686,-0.040901136,0.0721101,-0.09461814,-0.03718272,0.014063155,-0.0032418382,-0.010263165,-0.010583244,0.021009123,0.025099061,0.04745181,0.14476871,0.0488187 +4.2.3.100,The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor. With Mg2+ a more complex mixture is produced.,384,1.0,-0.06275248,-0.01412914,-0.035081584,0.013180369,0.100559615,0.038825102,-0.038175933,0.024483345,-0.04222862,-0.051133707,0.092806414,-0.046445563,0.059610065,-0.030328054,-0.013295191,0.09542714,0.02973766,0.10510981,0.0101496745,-0.028580884,0.10163954,-0.002876122,0.051240172,-0.025782224,0.05449963,0.046781797,0.033512477,-0.005592993,0.06351122,-0.05526347,-0.024184689,0.052171875,0.07135684,-0.11244621,-0.048545286,0.049263604,-0.020108098,0.021045184,0.05364104,0.01158989,0.053616818,0.06080796,0.05032336,-0.09398754,0.029100249,-0.079529695,0.044951428,-0.032975163,0.035773236,0.03720547,-0.028155688,-0.0071490197,-0.071362376,-0.021056734,-0.0024879966,-0.027116174,-0.06151432,-0.014984276,-0.030252675,0.02469098,0.010240259,-0.04985161,-0.020607533,-0.008504521,-0.005860271,0.014911628,-0.07314116,0.016002828,0.03573506,-0.039713472,0.023715813,-0.05581283,-0.018925106,0.04049857,0.0036538914,0.07073391,0.053801425,-0.03557087,0.04832057,0.01180669,-0.0085851215,0.04103399,0.0733727,0.037046295,0.025603808,0.026516825,0.052051365,0.06621847,0.0025891508,0.0072027324,0.022887172,0.08092408,-0.013327816,0.030567268,-0.007251642,0.06465956,-0.020517712,0.1031993,0.039542284,-0.023501279,0.020166794,0.00019550612,-0.056087747,-0.14276417,-0.01256793,0.0699069,0.06442035,0.045394555,0.0760496,0.060433652,0.010333212,0.015290526,-0.0025654822,-0.051849853,-0.039223433,0.04325253,0.051841702,-0.034448087,-0.0198992,0.0021829372,0.07103544,-0.009238338,-0.012574839,0.016673118,-0.035086717,0.06619304,0.012977516,3.8887157e-33,-0.0035404118,0.02798388,-0.016391343,0.039250292,-0.019712254,0.025378114,-0.045571372,-0.029597476,0.03303754,-0.05967665,-0.10424776,0.011830346,-0.06991812,0.07990732,-0.0497395,-0.10675377,0.045841202,-0.05825533,0.07986226,-0.0062164315,0.010516851,0.10310321,-0.08790041,0.02618503,0.042765096,0.02944388,0.09276497,-0.035330154,0.012597145,-0.048567858,0.015929045,-0.10263079,-0.07573773,0.001533848,0.011831393,-0.015365937,-0.022151254,-0.010353413,-0.052261602,0.015706474,-0.034548458,0.017549153,-0.09121232,-0.01052295,0.031214688,-0.07265722,-0.06684133,0.0823256,0.020621482,0.070461735,-0.00039223267,0.041979596,0.03429058,0.11206127,-0.068710975,0.017561601,0.030141212,0.016764259,0.042562384,0.0404514,-0.077203736,0.05033428,0.09017048,0.04474034,0.039560527,-0.01185693,-0.07528087,-0.05986293,-0.004933387,0.0011592743,0.016978351,-0.076754004,-0.011010029,0.028797055,-0.0467647,-0.07342001,-0.077300325,-0.071030006,0.023102466,0.032922257,-0.023625283,0.010508052,0.040855113,-0.030539248,-0.111004956,0.042749666,-0.05242301,-0.041857265,0.004782546,-0.03236234,0.04382865,0.031017598,-0.03094927,0.03532324,0.0014097379,-3.56965e-33,0.02590457,-0.05188845,0.09343019,-0.025244372,-0.10574818,0.009248311,0.014521844,-0.05702431,-0.014321578,0.078367606,0.02740486,-0.064873114,0.040643174,-0.049670283,0.024313534,-0.0018649051,0.061737105,0.17789102,0.009276498,-0.03594724,-0.054556735,0.07807551,-0.014492048,0.029991247,0.045558255,0.112002924,0.051638026,-0.010374086,0.0472256,0.060489822,0.031225687,0.009456717,0.008881664,-0.001180403,0.030534232,0.043914057,0.01890935,-0.028019696,-0.058053084,0.0170974,-0.040499624,-0.020108888,0.0064349286,0.0788237,-0.0029554158,-0.05326954,-0.03433476,0.045917347,0.012419737,-0.012642626,0.011854731,0.0036790068,-0.029182466,-0.047962926,-0.024085524,-0.04063746,0.040142454,-0.029995758,0.042899705,-0.050792184,0.01986177,-0.057162598,-0.025910327,-0.018609745,0.008799707,0.100104995,0.014811724,-0.028325463,-0.016989142,0.03270466,0.033949163,0.05675624,0.0042605214,0.020139642,0.00014613195,0.058431953,0.02694015,-0.04266847,0.0037137968,-0.07238758,-0.0078289,-0.03776522,0.0011995045,-0.038404424,-0.10445526,-0.0850725,-0.02832776,0.08431014,-0.011272616,0.05479725,-0.032561645,-0.06275548,-0.08842087,0.055653747,0.07517322,-3.1456675e-08,-0.030111598,-0.091222286,0.008352381,-0.04166836,-0.06464326,0.024144458,-0.034446992,-0.08791305,0.06631893,0.037527822,0.019970233,0.041549638,-0.07912678,0.008646574,0.03923849,-0.024594676,0.06010598,0.05827859,-0.036813535,-0.030334046,-0.010340065,-0.009519877,-0.13638628,-0.010210376,-0.004254555,-0.075904794,-0.0019814284,0.12505913,0.027962914,-0.01642092,0.0038076944,-0.03347883,-0.03325733,-0.08401432,-0.030293833,0.081909806,-0.005615601,-0.042331718,-0.042266745,-0.060722202,-0.07448442,-0.07471877,0.043170806,-0.010864162,-0.06004546,-0.100704655,0.018505763,0.0056626033,0.018636035,-0.028147614,-0.008768993,-0.102837294,0.023991829,-0.121372305,-0.08271357,0.016193897,0.009891352,-0.021105133,0.025909206,-0.058885682,-0.09668504,-0.014394477,0.112698175,-0.046868775 +4.2.3.101,"The enzyme from Zea mays, variety B73, gives mainly 7-epi-sesquithujene with (S)-beta-bisabolene and traces of other sesquiterpenoids, cf. EC 4.2.3.55 (S)-beta-bisabolene synthase. It requires Mg2+ or Mn2+. The product ratio is dependent on which metal ion is present. 7-epi-Sesquithujene is an attractant for the emerald ash borer beetle.",384,0.99999994,-0.023047008,-0.0148751335,-0.0355311,-0.0015542975,0.11232136,0.029023515,0.046280533,-0.005892387,0.0040349425,0.017482068,0.032689616,-0.048637953,0.054419786,-0.020441253,-0.050863747,0.073012784,0.054988068,-0.008509735,0.022307461,-0.06428636,0.03380934,0.022414846,0.060575485,0.012762824,-0.002408147,-0.027186288,-0.018124346,-0.011787083,0.03139361,-0.09995083,0.00621491,0.01989154,0.014734432,-0.07780887,-0.059431653,-0.05333365,-0.0762844,-0.038730714,-0.017824186,0.046192095,0.011941157,0.08700609,-0.030691456,-0.080103375,-0.09510227,-0.061491705,0.019669946,-0.025949685,0.010266663,-0.014706258,0.00797751,-0.098537534,-0.064489976,0.03153464,0.014496195,-0.099830925,-0.034054693,-0.04749438,-0.0012025129,0.04184771,0.108602405,0.006058022,0.021831056,-0.03250639,-0.0267014,-0.011847137,-0.010540772,-0.005120618,0.04105227,-0.09716548,-0.07078542,0.00817812,-0.040397316,0.07036981,-0.023320606,0.061625775,0.035254855,0.039784476,0.052059487,-0.06126037,-0.12435306,-0.01882725,0.04924972,0.038140703,0.04603034,0.10083673,-0.009060048,0.045092423,0.06092828,0.056979887,0.11855563,-0.019408701,-0.0066146776,-0.010374807,-0.043715708,0.061342984,0.04280239,0.0023137787,0.008967447,0.023601886,-0.028335197,0.07822639,-0.030618336,-0.10477016,-0.1569026,-0.0007163997,0.016443959,0.014617189,0.054879233,0.01778662,0.040659808,-0.10094312,0.09965627,0.032422952,0.008857985,0.0047661164,0.020294322,-0.06418323,0.0440803,0.06388195,0.059930637,0.00540624,-0.023382267,0.046063785,0.023268357,0.045187004,-0.09770746,4.46938e-33,0.073670596,0.12590343,-0.038679834,0.08570952,-0.032293286,0.034601126,-0.046514217,0.10540286,-0.03181455,-0.054876797,-0.1104384,-0.0716347,0.019789979,-0.0077465926,9.56779e-05,0.0030129887,0.008733784,-0.018470276,0.0948596,-0.030080175,-0.01571853,-0.08199393,-0.115894966,-0.05121658,0.06214683,0.090754084,0.035308752,0.014974847,0.052583437,-0.02433941,0.10445069,-0.008494003,-0.061323933,-0.0151439,0.052985985,-0.0021680342,-0.0073417043,-0.015277932,-0.09265328,-0.015518979,0.0649999,0.040648904,-0.02464748,0.0076275105,0.08211118,-0.045557093,-0.053118594,0.109262586,0.16629532,-0.033271525,-0.009096668,0.03704898,0.09546942,-0.007991504,-0.062681854,0.14204693,0.0036399749,-0.07025403,0.016127273,-0.015978158,-0.048585255,0.074203596,-0.0070309667,-0.043102253,0.01943308,0.0618154,-0.03982752,-0.041803543,-0.037172705,0.041638363,-0.024660943,-0.06252059,0.038189992,0.0013016602,-0.008717301,-0.04275219,-0.03515511,-0.079156235,0.056405287,-0.015852444,-0.026653491,-0.057439834,-0.014541861,-0.030201837,-0.05970429,-0.064982735,-0.016453529,-0.03407596,0.077285886,0.09021859,0.060611,-0.091645196,-0.01891059,0.017444689,-0.082266234,-3.267981e-33,0.015400707,-0.07229396,0.03351151,-0.026387645,0.04585509,0.06407415,-8.6794564e-05,0.0043780664,-0.009070215,-0.025331067,0.051587865,-0.010534031,0.08015674,-0.025131287,0.04622695,0.032407373,0.0494686,0.049380727,0.08781851,-0.024177399,-0.036143284,0.0076354872,0.056077957,0.018252088,-0.0022941062,0.044907056,0.047546197,0.02080786,0.045867536,0.020942852,0.025174415,-0.083254404,-0.0168073,-0.017088689,-0.092323914,5.304326e-06,0.005536067,-0.022791067,0.034138203,0.046445772,-0.01840495,-0.032201223,0.035460923,0.03943871,0.056972776,0.016581954,-0.03002447,0.028719002,0.051065363,-0.008556598,0.06011995,0.020283336,-0.11160145,0.00887731,-0.00025546155,0.032858275,-0.0060035517,0.01488686,-0.056957703,-0.06908111,-0.0039207637,-0.036703356,-0.006686599,0.027733661,0.025734752,0.057183713,-0.034389853,0.034941908,0.02154308,-0.06994717,0.03719859,-0.06849374,0.037478466,-0.004096522,-0.0040867412,-0.06689026,0.0455172,-0.059125155,-0.009940465,-0.08061676,-0.06363644,0.09386053,-0.0104735335,-0.05586565,-0.022097602,-0.02024378,-0.039654132,0.11788983,0.06350734,-0.008753182,-0.049013447,0.00028288926,0.019739805,0.015172057,0.05570795,-4.1815483e-08,-0.013017573,-0.0699729,0.020079533,-0.022241538,-0.04346926,-0.028601391,0.024348328,-0.03270171,-0.016602095,-0.010109098,0.049649093,0.0548801,-0.020364298,0.08953473,0.13060035,-0.040234983,-0.0069075283,0.011155653,-0.054591734,-0.056321815,0.006269554,0.029156206,-0.026340423,0.009638809,0.0046124114,-0.07395827,-0.027626758,0.00037452677,0.0006427831,0.008862785,-0.02265761,0.014990276,0.059015006,-0.06460406,-0.037629824,0.0362681,0.028169356,-0.0024484373,0.005205271,0.012566325,0.015981255,-0.06579725,-0.022443153,-0.0014949901,-0.022550153,-0.077216476,0.014004316,0.014542393,0.05546102,-0.025512898,0.035626426,-0.037228838,0.0041810013,-0.067021675,-0.058896504,-0.029605292,-0.021743024,-0.07127377,0.055474844,-0.03570861,0.030889558,-0.07167418,0.09706009,-0.02607955 +4.2.3.102,"The enzyme from Zea mays, variety Delprim, gives mainly sesquithujene with (S)-beta-bisabolene and (E)-beta-farnesene plus traces of other sesquiterpenoids, cf. EC 4.2.3.55 [(S)-beta-bisabolene synthase] and EC 4.2.3.47 (beta-farnesene synthase). It requires Mg2+ or Mn2+. The exact product ratio is dependent on which metal ion is present. ",384,0.99999994,-0.030419545,-0.05332927,-0.06368821,0.018182758,0.1331357,-0.023197643,0.027623247,0.040200267,0.04585837,-0.029211286,0.023743017,-0.03248334,0.054765552,-0.042654634,-0.00939758,0.03074635,0.070052624,0.031605925,0.01230954,-0.039756708,0.030612106,-0.020457717,0.050709028,0.009782106,0.06739112,-0.002276146,0.025100308,-0.013157509,0.034279432,-0.044429768,-0.010617739,0.010178319,0.044810522,-0.09497556,0.003969742,-0.033256374,-0.06810732,-0.07095354,-0.044991773,0.018561512,-0.001138571,0.085654244,-0.019612005,-0.042626075,-0.028109737,-0.06900953,0.003833694,-0.0069301967,-0.04282811,0.05592683,-0.032048203,-0.080961816,-0.06515838,0.071402,-0.017241556,-0.076688714,-0.048624057,-0.0034950213,-0.028937472,0.11502221,0.045261726,0.004851093,0.027755205,-0.06922311,0.01306651,0.0026658233,0.0023522414,-0.0063582403,0.04915728,-0.096500315,-0.07068178,-0.029458983,-0.023111517,0.047823306,-0.060108133,0.054167885,0.08767293,0.021873085,0.044686463,-0.036815472,-0.052072134,0.02354349,0.058925197,0.02077511,0.066209696,0.10814744,-0.041262433,0.04247729,0.06174803,0.053688556,0.0950578,0.01804607,-0.05976291,-0.044308003,-0.011588219,0.06266728,-0.01612419,0.015999073,-0.009076471,0.00283301,0.0019698143,0.09740465,-0.039888486,-0.09674131,-0.108973585,0.054089107,0.0409664,-0.004388241,0.028084623,0.035643972,0.03323628,-0.04355735,0.065297246,0.02562785,-0.002850145,0.051551078,0.05562831,-0.050875317,0.021422558,0.060075805,-0.012209153,-0.018647531,-0.03625303,0.064524144,0.02689741,0.11080603,-0.096436985,3.6212657e-33,0.048639983,0.13581611,-0.0017097034,0.08240857,-0.030694978,0.05740678,-0.03455705,0.095415324,-0.06725939,-0.054452408,-0.1181136,-0.097229995,0.030410111,-0.0021178797,0.014429986,-0.046066213,0.030776976,-0.046519756,0.0901605,-0.04691177,-0.029010301,-0.019322768,-0.07458146,-0.0027231453,0.07600438,0.06449788,0.0461349,0.038168233,0.0570672,-0.020397931,0.02453757,-0.044575386,-0.048321575,-0.038213488,0.046497706,0.021343792,-0.033704046,0.009992372,-0.084560566,0.029710071,0.017603843,0.0682808,-0.04599409,0.008082457,0.034279432,-0.09713728,-0.06669244,0.071190126,0.15056293,-0.0423047,-0.050545067,0.022866538,0.013843359,-0.03378653,-0.1121573,0.08938433,-0.04089291,-0.028361285,0.048045438,0.03760609,-0.072698526,0.052510023,-0.028380256,0.019114057,0.028724462,0.05994951,-0.10158348,-0.05597374,-0.033602323,0.040823266,-0.045964092,-0.04308615,0.04482923,-0.012172747,0.007605358,-0.047338825,-0.044950247,-0.09353137,0.11939011,-0.02467915,0.0032523528,-0.012150816,-0.002604894,-0.026244484,-0.058984224,-0.081302896,-0.060228482,-0.014621711,0.07087413,0.062256847,0.10610715,-0.0883015,-0.042215385,-0.017690834,-0.11554535,-2.8344614e-33,0.007204798,-0.0365467,-0.0003344967,-0.061712936,0.036719527,0.0135821495,-0.03286692,-0.01821989,0.01368416,-0.0020590818,0.08157013,-0.053408105,0.048825867,-0.036939453,0.0076660733,0.034170013,0.024153013,0.05926268,0.06838462,-0.00023460844,0.002614734,0.025181672,0.10126771,0.021997409,-0.011600559,0.033464592,0.016339434,0.014569384,0.033161033,0.074002445,-0.006849952,-0.102597795,-0.02752693,-0.03891068,-0.050477292,0.022322036,-0.047762338,0.021065913,0.041539133,0.041783925,-0.02065854,-0.033306327,0.037060563,0.08007084,0.04813486,0.018384386,-0.08395449,0.025460126,0.039698713,-0.05598141,0.049865063,-0.01784241,-0.10186943,-0.010689987,0.020188706,-0.0062825265,-0.0009774573,0.02914199,-0.10395286,-0.023819901,0.0028076852,-0.01569417,-0.004913723,-0.01919743,0.1145978,0.074907035,-0.007887864,0.0382946,0.04473113,-0.04935724,0.031569198,-0.019237472,0.010924324,0.0004968176,-0.027590787,-0.06610687,-0.012555504,-0.023185011,-0.008805966,-0.05825083,-0.006835791,0.01347851,-0.0075424677,-0.055140246,-0.046641447,-0.034537066,-0.018596403,0.14532591,0.05313653,0.03399953,-0.06566836,-0.04127797,-0.035113353,0.038065404,0.079526834,-4.387507e-08,-0.023119733,-0.0894047,0.005116805,-0.0014234195,-0.056514286,0.008055404,0.038027827,-0.03245454,0.025347454,0.012175219,0.011215302,0.06897718,-0.05981416,0.033814356,0.099062435,-0.044077262,0.0037993612,0.07234325,-0.015396272,-0.009287459,0.035782397,0.044198293,-0.021372162,0.008929896,0.02747293,-0.09396869,-0.036922812,0.029558303,0.01774392,-0.0058677895,-0.012005964,-0.034950174,0.06406728,-0.029345674,-0.053555224,0.0018674845,-0.006663555,0.010600124,-0.023233827,0.059223823,-0.021616232,-0.02535522,-0.04306035,0.0165102,-0.024544243,-0.06780111,0.04147802,-0.0105896145,0.051931273,-0.026749974,0.014356983,-0.09043564,-0.011616874,-0.035433926,-0.01818914,0.012163687,-0.025933942,-0.046593208,0.03287303,-0.08344205,-0.0015465987,-0.030521346,0.13201754,-0.031050485 +4.2.3.103,"Two enzymes of the rice sub-species Oryza sativa ssp. indica, OsKSL5 and OsKSL6, produce ent-isokaurene. A variant of OsKSL5 from the sub-species Oryza sativa ssp. japonica produces ent-pimara-8(14),15-diene instead [cf. EC 4.2.3.30, ent-pimara-8(14),15-diene synthase].",384,0.99999994,-0.10559314,-0.014817132,-0.06106472,0.027393106,0.042275168,0.049518637,-0.10564288,-0.0044781347,0.03567563,-0.059994295,0.11728022,-1.1047164e-06,-0.03218023,-0.009002773,-0.029731322,0.038917992,-0.030288171,0.07534214,-0.05016152,-0.09449129,0.061445303,0.00625772,-0.004534032,-0.01634869,0.07982041,-0.054254346,0.048237022,0.021958835,-0.011316452,-0.10510615,-0.019338965,-0.036980703,0.00565308,-0.04079115,0.060877424,0.0051331,0.020014597,-0.06359062,0.06908286,-0.034409795,0.047798667,-0.079533875,-0.08277139,-0.033639736,-0.035461266,-0.0823661,-0.08203382,-0.064139314,0.0014938957,-0.042173807,-0.047494046,-0.032068428,-0.037120555,0.031323604,-0.04049195,-0.117840715,0.014668076,0.02344411,-0.083012074,0.08247621,0.031557053,0.0071744574,-0.034977548,-0.0119461045,-0.094119735,0.029853564,-0.03573512,-0.0065033836,0.0008074573,-0.009209685,-0.030538142,-0.06731365,0.011391857,0.09784955,-0.07966581,-0.013051169,0.043318037,-0.0033605362,-0.0034169063,-0.04086531,-0.015815677,0.033363335,-0.025149798,0.062666595,-0.00013590325,-0.007439288,-0.057117514,0.100687616,0.06436673,0.052686617,0.064093776,0.013458793,-0.024978604,-0.013807363,-0.004073603,0.055017225,-0.046312086,0.0053793658,-0.0056908657,-0.030129919,0.003956582,0.01671294,-0.045901798,-0.0992939,-0.017298566,0.027352162,0.025339246,-0.07340462,-0.0017486025,-0.024344537,-0.022868093,-0.07545073,0.00802877,0.011922175,-0.053173855,0.02633626,-0.03568832,-0.028219707,0.001946299,-0.090647295,0.0080629075,-0.029775223,0.021175362,0.073371254,-0.041640572,0.04032592,-0.0795383,2.978076e-33,0.079193585,0.03988686,0.024833033,-0.013064157,-0.021514153,-0.045390576,0.011375987,0.0068407203,-0.051047865,-0.036875352,-0.1486934,-0.07901629,-0.06675324,-0.021220978,0.043060336,0.016895562,-0.00480781,0.013593337,-0.009560863,0.058235064,0.0066714226,0.06663798,-0.0720794,0.004531265,0.032391626,0.003301227,0.044649005,-0.057081155,-0.010267801,-0.03405627,0.021423718,-0.02192651,-0.07880666,0.029294588,0.015081452,-0.021821527,0.056684896,0.016308695,-0.004726066,0.04705675,0.09842891,0.067518815,0.02099513,0.032571003,0.09204712,0.055575326,-0.05944297,0.09684233,0.07758339,0.02171432,-0.035426155,0.06123153,0.049251832,0.027279366,0.0161699,0.018140571,0.034095224,0.031622704,0.01588287,0.034334805,-0.061024975,0.003310072,0.05038658,0.010786506,0.035725582,0.050010547,-0.11672415,-0.052062463,-0.031808194,0.07390283,-0.05181992,-0.031416375,0.0042285887,0.021238152,0.04021226,-0.074529566,-0.05271653,0.04005323,-0.013239352,0.051088262,0.013450342,-0.011229335,-0.008111148,-0.034369938,-0.0604456,0.033655316,-0.07060035,0.014193209,0.059555538,0.052345462,0.08011653,0.03303299,-0.0031745262,0.056506515,-0.030113747,-2.8416724e-33,0.05791026,-0.04402158,0.030300789,-0.018714495,-0.057427514,-0.0055166073,-0.046315648,-0.0023855637,0.056524176,0.113885716,0.06774141,-0.056273066,0.11043333,-0.068169005,-0.016765304,0.05100583,0.05330936,0.12067805,-0.013016295,-0.021682467,-0.0704901,0.1203739,0.03146895,0.01915054,0.09035722,0.049876064,0.067980684,0.07372088,-0.06350863,0.027795501,0.059725653,-0.033675745,-0.01834292,0.01109961,0.012985782,0.032204486,0.012943756,-0.01822363,-0.005735401,0.055732824,-0.0519102,0.0207837,0.02973109,0.07324796,-0.024726719,-0.060100604,-0.02047474,0.030915465,-0.029848263,-0.11263617,0.05000408,-0.007850445,-0.035151564,-0.0035480936,-0.008730225,0.013831475,-0.00013854918,0.0677752,-0.08688482,-0.04146376,0.03156651,-0.013522196,0.07343708,-0.04314781,0.029647004,0.03494424,0.002094994,0.02108647,0.012512887,0.0036355744,-0.022825742,-0.05202584,-0.0030430949,0.051507108,0.024012364,0.013380419,-0.050326478,-0.01614093,-0.027768148,-0.006566403,-0.055089943,-0.030328155,-0.032353524,-0.060866818,-0.050133128,0.017366242,0.021354508,0.09310383,0.041159477,0.06671624,0.0066271564,0.0061934735,-0.08024105,0.13494171,0.041042075,-3.9632667e-08,0.08036893,-0.1414106,-0.0050219586,0.026073674,-0.089683875,-0.06759307,-0.010578814,-0.010043103,0.065168835,-0.006954153,-0.05626158,0.09749241,0.010094372,0.0055279504,0.01875367,-0.05151627,0.06504314,0.13283198,0.007575541,0.006929894,0.02786071,-0.03264331,-0.04192971,0.0019850202,0.025943274,0.0051312316,-0.048593726,0.028664986,0.15811858,-0.054801926,0.023731172,-0.043335,0.029766694,-0.053075776,0.055752568,0.09277122,-0.041397605,-0.045134667,0.025538191,0.047904287,-0.030601671,-0.07471841,-0.03595455,0.02771877,-0.042493768,-0.039896306,0.03920128,-0.03556049,0.0092140725,-0.018844888,-0.027677787,-0.062337924,0.05434125,-0.09900438,-0.027254786,0.05355351,0.028879665,0.006023176,0.023407444,-0.0043412144,-0.02618383,0.02334034,0.13686894,0.02602953 +4.2.3.104,"The enzyme from Zingiber zerumbet, shampoo ginger, also gives traces of beta-caryophyllene. +",384,1.0,-0.07209721,-0.018660087,-0.06364973,0.015012771,0.07318783,0.08376655,0.0629922,0.040936045,0.0006359942,-0.057507146,-0.017676685,0.03708116,-0.08496919,0.013673116,-0.10710761,0.008802679,-0.06342447,-0.019014291,-0.022040242,0.0008343331,-0.017501874,0.050420366,0.057016052,0.0017033569,0.07523294,-0.029425329,0.0003759613,-0.0015196137,-0.048658535,-0.05049897,0.09000821,0.028493928,0.008469688,-0.042627648,0.031415176,-0.024269225,-0.011850195,-0.10859259,0.014026557,0.04955823,0.054897618,0.019275762,-0.068010174,0.0039149136,-0.018510677,0.062287975,-0.00029941098,0.041459426,0.00646804,0.0054622213,-0.09405158,-0.09947756,0.021749824,-0.01563306,0.015988322,0.053116478,0.052453373,-0.042790473,-0.058926184,0.07879405,0.014973419,-0.0019774989,-0.07576514,-0.012589583,-0.05395848,0.010927345,0.0027007884,0.007780597,0.056759726,-0.052864484,-0.07606286,-0.07163148,-0.052282024,0.059228584,0.006254252,0.030482583,0.00074400497,-0.0696727,0.0011462905,-0.012731773,-0.03393308,0.03998631,0.067465186,0.04496629,0.07237976,0.0794574,0.018589161,0.026215069,-0.022744957,0.06486837,0.039044768,-0.011986679,-0.017387468,-0.008850602,-0.06291183,0.056051005,-0.00029709493,-0.059832823,0.070595235,0.01849869,-0.018079076,-0.062069494,0.015823362,-0.120586656,-0.097230524,0.04786178,0.062154442,0.007818872,0.024427995,0.015198924,-0.026230078,-0.010428448,0.0061861933,-0.05986006,-0.034514073,0.04697856,0.09575282,-0.015485656,-0.10760272,0.00015143184,0.039152835,-0.09316696,0.057896577,0.013138141,-0.06590145,0.09498031,-0.1328206,1.373191e-33,0.069391206,0.07755193,0.04365258,0.013783078,-0.025651373,0.06562995,-0.05471928,0.042994145,0.013915308,-0.027248338,-0.028381402,-0.047659248,-0.018784788,-0.053474143,-0.0441319,0.07690295,-0.06881781,0.01832133,0.01653363,-0.048878375,0.043862738,0.02342764,-0.078465275,-0.034318678,0.034146126,-0.040242646,-0.02225566,-0.03822528,0.045385025,-0.005487897,0.08748959,-0.055331435,-0.07043181,0.019218436,0.025756136,0.0199567,-0.060188483,-0.10127793,0.0057560736,0.06947387,0.07294316,-0.0046924595,0.056317713,0.0666725,0.009441536,0.010605406,-0.074840955,0.036261514,0.056768507,0.042478465,0.035057727,-0.0028583137,0.00724291,0.06317724,-0.078343146,0.0796803,-0.08346583,0.016328642,0.08786164,0.044771858,-0.019165836,0.10669718,0.010778962,-0.06606717,0.0017222826,0.004973774,-0.07096173,-0.020632273,-0.04763465,0.047627144,-0.043839585,-0.04477989,0.08859419,0.019234024,0.029040802,-0.034036256,-0.034484584,0.0033796777,0.057071645,-0.07127172,0.0067889076,0.03494999,0.018710895,-0.03375704,-0.057025813,-0.060679186,-0.022391403,0.006362946,-0.049862903,0.0074223266,0.112172775,-0.00055623316,-0.07499471,-0.010858318,-0.101054184,-1.0816679e-33,0.008145577,-0.06524676,0.0077231186,-0.028390309,0.0242067,-0.03081579,0.03236397,-0.08467006,0.029203897,-0.051943637,0.060059443,0.017072832,0.099235594,0.0018250803,-0.04028096,-0.0037470518,0.03613562,0.059641737,0.038190447,-0.012375954,-0.063914195,0.0069956016,0.06030162,0.014372154,-0.030394634,0.006345593,0.07949664,0.017215824,0.11815423,0.01773178,0.075098805,0.03748137,-0.050418366,-0.1270315,-0.03655071,-0.015035922,-0.019802922,-0.014042997,-0.0024043284,-0.044375964,-0.020750964,-0.062000338,0.015278182,0.011001635,0.07567973,0.02892392,-0.04536282,0.030995736,0.0055354186,0.022674222,0.096569195,0.02479229,-0.04263024,0.0644876,0.0041928687,0.03252676,0.010969324,-0.045539685,0.030681005,0.03919433,0.04270264,0.029261962,0.0010880353,0.041923553,0.056116354,0.017759755,0.1182547,0.03047811,0.00047334458,-0.0125775235,0.074736975,0.035231326,-0.01896905,0.034811746,-0.09470804,-0.0053875726,-0.078346275,-0.036759432,-0.011861136,0.0007114563,0.0022570845,-0.015067381,-0.012190329,0.003561128,-0.00113266,-0.0527505,-0.05360457,0.06013041,0.032490082,-0.062872775,-0.029084899,0.024882693,-0.021965507,-0.0012430972,0.037671108,-2.3849378e-08,0.085235044,-0.07350936,0.07308008,-0.0094189625,-0.038617227,-0.05761009,0.058676783,0.017449563,-0.039073993,0.0012133678,-0.031699114,0.12702173,-0.04783027,0.0035818554,0.07564887,-0.030690204,-0.017444298,0.0033691947,-0.043447223,-0.0044377325,-0.026563665,0.09156197,-0.045051802,-0.012449998,-0.056868535,-0.037004344,0.077790216,0.07292459,0.06521886,-0.06257915,0.07296491,0.08549352,0.045012627,-0.027865155,-0.10880437,0.00715,0.008425637,0.015029263,0.0019559003,0.003502486,-0.0041824323,-0.096055955,0.032527342,0.0068477755,-0.041969284,-0.07619652,0.04803046,-0.05010439,0.07731259,-0.055738807,0.08041906,0.037169103,-0.04669094,0.038795847,-0.053829234,-0.0024070654,-0.015697787,-0.042504895,0.042775515,-0.04915142,-0.06434591,-0.09027184,0.1267609,0.061605148 +5.4.99.57,The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids.,384,1.0,-0.033883534,-0.07501611,-0.10699603,-0.031000583,0.00094194105,0.055353392,-0.08200613,0.03987515,0.091117166,0.018038584,0.14923507,-0.061772827,-0.028075244,-0.09811219,-0.0013059147,0.0147186,-0.05250513,0.024708401,-0.013191538,-0.107176796,0.06617638,0.05744481,-0.020497546,-0.040495086,-0.0029405435,0.017205777,-0.03869022,-0.05301698,0.0026585625,-0.06706446,-0.028287617,0.060904883,-0.0017175941,-0.03573726,0.041175984,0.035773113,-0.0631034,-0.06960183,0.12730849,0.024592165,0.09453426,-0.014181701,0.051807795,-0.020187108,-0.07289249,-0.0022201461,-0.06441051,0.070192486,0.03293588,-0.012997138,0.015003499,-0.015282318,-0.04358516,0.017031506,-0.000957156,-0.040903896,0.05287397,-0.027669083,-0.022505132,0.08455405,0.042482685,-0.04270787,0.056127634,-0.026157618,-0.06032558,-0.03203294,-0.028255982,-0.01045512,0.033194225,-0.047662806,-0.024237264,-0.052384984,-0.08831746,0.016017232,-0.083048396,0.048433814,-0.002718667,0.046680085,-0.028698694,-0.057950687,0.05267071,-0.0063742986,0.090192385,0.104493044,0.057103697,-0.014883934,-0.01618545,0.0401956,0.028843926,0.07492984,0.053948525,0.018736374,0.038598176,0.005430784,-0.07212868,0.06812162,0.032672454,0.013136874,-0.051739227,-0.07316942,0.0352723,-0.006305683,-0.04017149,-0.08582303,-0.039732065,0.08596796,-0.06118558,-0.0736398,0.03129533,-0.025361978,0.0074239946,0.015940124,-0.014843993,0.013397067,0.031413864,0.0224951,0.039339885,-0.041899543,0.0132770715,0.0055508,-0.017361801,-0.020597802,0.060664967,-0.011704571,-0.038689706,0.0022155282,-0.08050798,1.7743529e-33,0.04068338,0.10038434,-0.05336382,-0.021109156,-0.053297877,-0.025746351,0.00092646846,0.11836989,-0.05497419,-0.05214153,-0.106502265,-0.020385675,0.0021283312,-0.0274859,-0.025227906,0.016869958,-0.00068733667,0.009382709,0.0743268,-0.038594853,-0.066883706,-0.03954428,-0.06544819,-0.046447095,0.02025528,0.06660439,0.0092794,-0.029614752,0.029259909,-0.053591903,0.011486251,-0.086127,0.0100998795,0.05896186,0.07185634,-0.036442887,0.015988335,-0.034732528,-0.12934174,0.043199215,-0.02286925,0.06453472,0.045847047,-7.6785465e-05,0.05354754,0.008399312,-0.07017552,0.00064937276,0.08290009,0.029940013,-0.0053491187,0.07124421,0.090700954,0.012420553,-0.07447597,0.0047217133,-0.0135819,0.022224795,0.010291531,0.056997176,-0.027105445,0.067799106,-0.037766486,0.026536217,-0.040556375,0.12987936,-0.14160593,-0.10235236,0.008849962,0.17928514,-0.022821186,-0.0341652,0.08084146,-0.052613325,0.11531572,-0.015559139,-0.050554875,-0.018271191,0.008699521,0.02055179,0.02090634,-0.041495416,0.036896978,-0.011083636,-0.059716206,-0.0406243,-0.023681642,0.0006930893,0.007371681,0.03406709,0.10949719,-0.012475741,-0.066182956,-0.0059953006,-0.006534315,-1.9480004e-33,0.016190488,-0.0069846776,0.0046454356,-0.09362632,0.0013204712,0.09387517,-0.048101965,-0.06706537,-0.010305477,0.026445292,0.05635718,0.0069412496,0.015509446,-0.05617391,0.0251412,0.0064735594,0.046189852,0.07150699,0.012585456,-0.05160529,-0.02404447,0.013555051,0.019849481,0.0527234,-0.033323005,0.014599961,0.050620936,0.0011055411,0.003028917,0.027733063,0.03992363,-0.04634944,-0.012229738,0.038549438,-0.022656024,0.040916245,-0.02590968,0.035099916,0.009294982,0.028409978,-0.01385462,-0.03145132,0.010718373,0.101903886,0.007863547,-0.023546148,-0.110001594,0.06116959,-0.04309194,-0.013489104,0.052539624,0.028534966,-0.047313187,0.03449587,0.0042377063,0.005780215,0.0024562143,-0.006338824,0.02057869,-0.0216591,0.009878915,-0.06809649,-0.08090355,-0.0108624,0.04228561,0.028298201,0.011722275,0.028419353,-0.036187865,0.10246684,0.036146685,0.10260975,-0.03878854,-0.00804909,-0.014538236,0.0030272831,-0.016991686,-0.15562205,-0.0536003,-0.008586411,-0.036611926,0.0003261186,0.05551237,-0.0492522,0.005719925,-0.05952094,-0.00502193,0.07027693,0.027144048,0.08101402,0.018137144,-0.004041207,-0.07761149,0.043668766,0.041482985,-2.288957e-08,-0.004931988,-0.01737931,0.017108083,-0.02911971,0.027958428,0.02151336,0.018259361,0.041763518,0.04298236,-0.0068881563,-0.030659648,0.043032113,0.007674283,0.055256367,0.1276604,-0.01439789,0.047686115,-0.0013442538,0.001466353,0.028135715,0.007826983,0.028084623,-0.08271858,-0.021370552,-0.041870132,-0.052308008,0.039961107,0.021698883,0.03860456,0.012309084,0.06250283,-0.03097007,-0.010757232,-0.025738677,-0.044684485,0.009336685,0.00051382516,-0.053432737,-0.012642378,0.031038847,-0.054139365,-0.031524207,-0.12607299,0.06684729,0.011888121,-0.030582665,-0.009812837,-0.076455474,0.045059454,0.050883424,-0.0044900356,-0.0028874981,0.026057506,-0.0135895265,-0.060055625,-0.06597117,0.009293281,-0.008287272,-0.021580568,-0.028137792,-0.018695518,-0.0149539085,0.21570362,0.03461002 +1.1.1.318,"The enzyme acts in the opposite direction. The enzymes from the plants Ocimum basilicum (sweet basil) [1,3], Clarkia breweri and Petunia hybrida [4] only accept coniferyl acetate and form eugenol. The enzyme from Pimpinella anisum (anise) forms anol (from 4-coumaryl acetate) in vivo, although the recombinant enzyme can form eugenol from coniferyl acetate [5]. The enzyme from Larrea tridentata (creosote bush) also forms chavicol from a coumaryl ester and can use NADH [2].",384,1.0,-0.057061914,-0.06344584,-0.098821886,-0.045046777,-0.004913816,0.102081515,-0.09895313,-0.025152104,0.025270248,0.030827047,0.10364656,-0.011058565,-0.05529946,-0.005521432,-0.087067015,0.047949195,-0.02516981,0.037932098,0.027716972,-0.078917205,0.014007133,-0.032375228,-0.034086585,0.024959043,-0.022492027,-0.058796816,0.02155786,-0.024203759,-0.025451101,-0.104849115,0.019146858,0.01751825,0.0100493,-0.05393994,-0.025409324,0.031685196,-0.015251243,-0.08017454,0.073542155,0.016566666,0.023270827,-0.031538367,-0.08270276,-0.016445613,-0.046505943,-0.08200298,-0.022001883,0.03555681,0.0755563,-0.03952174,-0.05817676,-0.026227523,-0.04630569,-0.06466283,-0.09305041,0.030393578,-0.024874957,0.001226149,-0.03590327,0.10363355,0.016161397,0.047172025,-0.062987715,0.05359324,-0.05009472,-0.014595975,-0.008671223,-0.02019071,-0.007890661,-0.05951564,-0.012826359,-0.14452353,0.061893966,-0.013245759,0.035254437,0.028022485,-0.017654916,0.0030372855,0.044201855,-0.04894729,-0.060159784,0.021046942,0.0020441061,0.03614678,0.0792394,0.03367345,0.0037955167,0.03228327,0.12428763,0.043474846,0.011699887,0.021666441,-0.05856397,-0.029790811,0.015102516,0.06372711,-0.0041424423,-0.008055731,-0.0020045526,-0.037110105,0.016761564,0.029096592,-0.0156958,-0.0679566,-0.04979561,0.039551865,-0.04801075,-0.0005708764,0.08656399,-0.007246573,-0.023492843,0.0028554727,-0.008182602,-0.052155256,-0.06923689,0.06782937,0.0138178365,-0.10364752,-0.022827212,-0.02712119,-0.0033170774,-0.07493915,0.007153687,0.04985703,0.015145678,0.03797843,-0.08662882,4.1158043e-33,0.056340344,0.033478066,-0.038129028,0.0002101836,-0.06796084,0.02085931,-0.06576569,0.048018314,-0.10811176,-0.04166456,-0.0775299,-0.031295955,-0.017789267,-0.0053669405,0.03823666,0.03059836,0.028028395,-0.0048425603,-0.007578374,0.007979094,-0.0040388773,0.07889769,-0.07829322,0.005819951,0.025950918,0.04031398,-0.024544813,-0.02812166,0.045437112,0.0133651905,-0.009406071,-0.13476677,-0.044364966,0.06302112,0.028012874,0.027603444,-0.07704186,-0.041109513,-0.001491158,0.077719994,0.016286751,0.04640581,0.060634416,-0.005883307,0.035710484,-0.06258942,-0.003872665,0.002372331,0.062429227,0.0738028,0.031624373,0.034170378,0.109652534,0.04396633,-0.0949577,0.07223985,-0.058253054,0.07319233,0.06215485,0.0051056123,-0.025998313,0.017447809,-0.031015377,-0.03560659,-0.00083503174,0.0075629796,-0.053363368,0.011332247,0.025587615,0.08478841,-0.0341029,-0.019237924,-0.039252494,0.018341182,0.07075981,-0.030851297,0.049825273,0.030250413,0.022403495,-0.03821763,-0.0046524215,0.06710087,0.048170038,0.046021298,-0.02560383,0.011688932,-0.0044351146,0.10084395,0.009841504,-0.0024201395,0.15763523,-0.0433487,0.05348632,0.007183216,0.03240556,-4.7975113e-33,0.023733811,-0.07928746,0.0325945,-0.11198307,-0.07779886,0.0749738,0.05019814,-0.009971285,0.0053113187,-0.0025519996,0.03228255,0.039568804,0.07404188,-0.054750115,-0.046867754,0.055483416,0.060996,0.08780118,-0.037919506,-0.01457036,-0.06345739,0.13947567,0.07739492,-0.017809981,0.003767234,0.00041996266,0.041654773,0.04105161,0.029986184,0.0153943375,0.03558275,0.02588065,-0.03499568,-0.023415875,0.0032559643,0.025251599,-0.06699709,-0.045333985,0.0059891515,0.052843295,-0.031552736,0.032942936,0.026926385,0.02373185,0.058096346,0.029929062,-0.07478891,0.014522972,-0.058758594,-0.011247077,0.03825179,0.030403921,0.02326733,-0.013888041,0.025596667,-0.04351399,0.037290666,-0.046627853,-0.049507063,-0.029474983,-0.028214417,-0.038310725,0.013142065,0.040032305,0.018659165,0.0643319,-0.029748905,0.036901776,-0.062235992,0.021745324,0.04896228,0.110155486,-0.031905457,0.102193095,0.04524585,-0.03247735,0.030063711,-0.04519078,-0.0382747,-0.06078928,-0.03191992,0.0012434594,0.025590004,-0.089868136,-0.060001068,-0.08640427,-0.019766137,0.02708832,0.05790623,0.03280079,0.0069543174,-0.018432273,-0.032209758,0.015154195,0.11370971,-4.1367187e-08,-0.027804524,-0.03604554,0.06257103,-0.089979805,-0.03770249,0.01979589,0.046852946,-0.07480037,0.05285231,-0.069801375,-0.04939268,0.07588919,0.035884004,0.031528372,-0.011921333,0.04217513,0.018479152,0.03844159,-0.014699436,0.033551678,-0.027606158,0.06260545,-0.07635344,0.014113199,0.033579364,-0.046883017,-0.0011046329,0.021306038,-0.006561665,0.015353427,-0.005227781,0.03665737,0.00036259947,-0.059432264,-0.053111665,0.018291552,0.06283486,0.023070076,-0.038237132,0.03720445,0.06726853,-0.046373967,-0.032438572,-0.012400491,0.0037680627,-0.012055722,0.053100426,-0.04133024,0.052234914,5.081977e-05,0.04576137,-0.010079534,0.03333261,-0.09492,-0.080022246,-0.15428361,0.01446244,-0.10262614,0.037135165,-0.14677052,-0.02193953,-0.009860294,0.17135364,0.03075481 +1.1.1.319,"The enzyme acts in the opposite direction. In Ocimum basilicum (sweet basil), Clarkia breweri and Petunia hybrida only isoeugenol is formed [1,2]. However in Pimpinella anisum (anise) only anol is formed in vivo, although the cloned enzyme does produce isoeugenol [3].",384,1.0,-0.07567872,-0.093544334,-0.11372855,-0.020755462,-0.06443313,0.024942076,-0.09013788,-0.06158002,0.051054806,0.00888116,0.13032979,-0.03216952,-0.019277222,-0.026828,-0.08795436,-0.0017950755,-0.047924425,0.067539334,-0.016827598,-0.09041967,-0.0051120603,-0.09089538,0.05819616,0.0047924896,-0.022539157,-0.044671286,0.011906375,0.0060329214,0.039484937,-0.14810306,0.021219924,0.04404284,0.01280641,-0.1145086,0.019177213,0.03456509,-0.014381128,-0.016698517,0.06334245,-0.02809601,0.06470994,-0.06399852,-0.081991374,-0.01737118,-0.06267463,-0.052424215,-0.03959269,0.0005621324,0.053565636,-0.052805677,-0.046873122,-0.04776534,-0.05894714,-0.016342698,-0.11936913,0.03372372,-0.009606741,0.023946853,-0.026605865,0.052562084,0.013334211,0.04857845,-0.055418435,0.048729368,-0.008190196,-0.004230689,0.01136612,-0.098587416,-0.039062113,-0.038974117,0.015788095,-0.12578337,0.04556905,-0.0023857695,0.047355384,0.07415172,-0.010409098,0.017325649,-0.0023814477,-0.022431524,-0.072065145,-0.05900258,-0.0032458648,0.04937988,0.023511536,-0.020213874,0.0020716959,0.028993085,0.08947266,0.059722774,-0.040544212,0.082334146,-0.014751232,-0.036816712,0.039224867,0.013780691,0.006143881,0.056837987,0.019924048,-0.0437411,0.012754365,0.026869893,-0.022057211,-0.043479774,0.0033836109,-0.014514024,-0.046099577,-0.05819756,0.10203992,-0.0114630265,-0.011414581,-0.012450832,0.06482023,-0.052667376,-0.051634986,0.030174047,0.015554828,-0.05930586,-0.012254911,0.005476658,-0.048892066,-0.05642249,-0.022690192,0.07575628,-0.0028384873,0.023821702,-0.08727047,2.8843132e-33,0.061737202,0.016219784,0.010325425,0.0050135558,-0.06535491,0.05777912,-0.028338304,0.0223746,-0.104332365,-0.09788122,-0.09965029,-0.024560617,-0.027996415,0.017062131,0.030874953,0.008506196,0.038859967,0.0020817718,0.016741412,-0.024446355,0.0015105961,0.058370538,-0.08333929,-0.012773005,0.060049128,0.057681557,-0.027255716,-0.0628668,-0.0313911,0.016194342,-0.0408723,-0.093747705,-0.060295425,0.068257295,0.060500804,0.06552882,-0.02738584,0.0034652187,-0.016898926,0.08392065,-0.0060607577,0.016875552,0.048018,-0.039589863,0.04795344,-0.030531047,-0.06669132,0.0017022765,0.09979098,0.0900648,0.004293339,0.009500267,0.11335415,0.029634522,-0.07981305,0.04286913,-0.0049913293,0.056450386,0.03239069,-0.0015388448,-0.036182206,0.08822257,-0.010272473,0.0073702964,-0.00091960654,0.033883836,-0.08144161,-0.0020037184,-0.01798962,0.053605262,-0.070443794,-0.0023543087,-0.021867054,-0.0031449178,0.0777411,-0.01873867,0.00085573166,0.0104625,0.03268726,-0.041457344,-0.008688587,0.08412913,-0.01774679,-0.025591146,-0.05284256,0.007992805,0.028478224,0.09574264,-0.01645798,0.0033106648,0.1510071,-0.017870031,0.03504246,0.045153722,0.059413716,-4.686291e-33,0.01808504,-0.067102835,0.032633983,-0.091290876,-0.09915036,0.057223104,0.0015739283,0.023632217,-0.016796142,0.062696256,0.041627906,0.000242738,0.016831787,-0.0113607785,-0.089152485,0.03473066,0.09826204,0.09843956,0.01848212,-0.0016590673,-0.13515362,0.099985674,0.025753897,0.039047882,-0.004549315,-0.0014651354,0.06142201,0.042800266,-0.012653696,0.0070707505,0.004407631,0.050042517,-0.040907163,-0.015644174,0.0022394795,0.057467416,-0.06059187,-0.045842346,0.022114046,0.022335034,-0.059935875,0.0034614708,0.049975365,0.061447673,0.06354854,0.011348681,0.00039051232,0.024097316,-0.11535382,0.0011700325,0.05090065,0.036495693,0.015812127,0.025326809,0.026501594,-0.0114980135,0.024762137,0.003046155,-0.08136492,-0.07991617,0.0007797699,-0.033739645,0.022438833,0.04263141,-0.012282125,0.08485604,-0.0064882487,0.06511592,-0.017691987,-0.004144189,0.05583617,0.1054428,-0.02737605,0.041792568,0.039153017,-0.0004503443,0.04971834,-0.07266762,-0.030360874,-0.084302194,-0.0657698,0.023777016,0.010643283,-0.106107384,-0.042935,-0.0873138,-0.030941935,0.004348679,0.014211794,0.026099902,0.05903678,0.015893271,-0.0692174,9.67961e-05,0.1321631,-3.535738e-08,0.0067261406,-0.014245388,0.018158527,-0.006181379,0.0019949714,-0.022107795,0.04238192,-0.06524956,0.054795753,-0.015427009,-0.035103183,0.0714934,0.047594883,0.01619431,0.03215433,0.06715568,0.026859773,0.056862835,0.011008296,0.07243268,-0.08006724,0.03535858,-0.06986801,0.005325417,0.006315591,-0.038954087,0.020616556,-0.034471106,-0.02943585,-0.004825439,0.04320075,0.039222922,-0.04403772,-0.050628096,-0.018806722,-0.004062364,0.067448385,0.027021473,-0.015248263,-0.0002405142,0.032898895,-0.037513465,-0.055167586,-0.008945745,0.0054264255,0.015477945,0.017774403,-0.068226315,0.043138646,-0.016859693,0.018124294,-0.0032511388,0.07516903,-0.09574332,-0.07018452,-0.078111246,0.021271538,-0.0110862,0.0048898947,-0.07584893,0.00969806,0.022991436,0.15897089,-0.0019454504 +1.1.1.320,"The enzyme also reduces 1-phenylpropane-1,2-dione. The enzyme from Bacillus cereus in addition reduces 1,4-naphthoquinone and 1-(4-methylphenyl)-2-phenylethane-1,2-dione with high efficiency [2].",384,1.0,0.006711484,0.019554486,0.037422433,-0.038599364,0.021033887,0.035676513,-0.07365556,0.061186876,0.07076303,-0.031308856,0.0073219673,-0.03867322,0.04071975,0.104779996,-0.03543989,0.006610832,-0.07481086,0.050354294,-0.040216316,-0.050196495,0.017173111,0.0001932636,0.025444767,0.05400327,0.021236964,-0.07615493,0.044289656,-0.04838918,-0.039062116,-0.04956764,0.09483293,-0.055453088,0.020898825,-0.021253971,-0.018252855,0.009215922,0.018505912,0.005453871,0.04192717,0.054811727,0.03006343,0.035988513,-0.058676872,-0.05318718,-0.026719319,0.047028866,-0.024954244,0.0065929587,0.051145557,-0.017430352,-0.0783547,0.0067444136,-0.022320826,0.026051478,0.016499296,-0.038535003,-0.059735913,0.05176243,-0.015234679,0.02240074,0.04801321,-0.040526524,0.06856569,0.02219104,-0.046573263,-0.046573125,-0.0022026824,-0.044137444,-0.038072567,-0.013499433,-0.05288518,-0.05283028,0.06579414,0.0040152106,0.05938512,-0.021469055,-0.011132461,-0.06549232,0.020943694,-0.051161576,0.0071432693,-0.020807821,-0.011358967,0.09091149,0.033594824,0.036244202,0.044626415,-0.05913228,0.079785556,0.0082894,0.13045783,0.017425029,0.016020833,-0.044279125,-0.07968275,0.025454754,-0.038482856,0.042894624,-0.026677242,0.0213343,-0.04390349,0.004603152,-0.08047299,-0.06731914,-0.04846474,-0.011991053,0.086755045,-0.0036844702,0.04047896,-0.04195058,0.10391431,-0.001349926,0.030815102,-0.033350516,-0.085350305,0.09243016,0.036993008,-0.018897641,-0.06613093,-0.064376116,-0.024081325,-0.08543514,0.0901962,0.010647216,-0.10297964,0.026406612,-0.043388013,2.4158683e-33,-0.017055392,0.051857058,0.007491387,-0.037927613,0.065961614,-0.047119983,-0.10093075,0.05989381,-0.063514784,-0.161247,-0.057066645,-0.03802908,-0.001276102,-0.0046361494,0.032281693,-0.023107314,0.019803021,0.038916893,0.050220575,-0.04683936,0.027835812,-0.036983196,-0.024082514,0.042884625,0.05172619,-0.027647078,0.057146225,0.06264877,-0.024664072,-0.043346763,-0.015102549,-0.08735824,-0.05706059,0.024428276,-0.022642912,0.021222351,-0.07303499,-0.034870338,-0.016823146,0.013155023,-0.06588957,0.05986197,0.05893498,7.610492e-06,0.036473203,-0.06569065,-0.04955867,0.07788631,-0.022035118,0.08407624,0.046226,0.034353852,0.09137005,-0.01728332,-0.06565974,0.032418504,0.029406384,-0.05660037,0.049005907,0.0006939526,-0.024290303,0.0028785272,-0.046013396,-0.022448992,0.02241087,0.010759304,-0.0060583525,-0.00582641,-0.047371913,-0.005431823,-0.06869194,0.02352849,0.07200943,-0.021219514,0.048274793,0.0052690953,-0.013451875,-0.07855924,0.015019022,-0.059730157,-0.06972897,-0.017696705,0.04222284,-0.020613706,-0.018144991,-0.0032845484,-0.008747573,-0.037941914,0.029016588,0.023087196,0.06668402,-0.11182562,-0.07456328,0.058149047,-0.008174409,-9.456022e-34,0.057044484,-0.06978685,0.047780823,-0.066330485,-0.018935548,0.014904858,0.091543026,0.0030016492,0.01430852,-0.06108607,0.095774405,-0.042589698,0.0109822815,-0.0009733314,-0.0017727668,0.073400155,0.06381725,0.055431455,-0.017594768,-0.018529596,0.026539052,0.11131393,-0.006712639,0.036647227,-0.016487122,0.062093407,0.019817008,0.13587454,0.083669625,0.021335578,-0.002436489,-0.004780791,-0.019171683,-0.013328965,-0.037646323,0.09229183,-0.005961148,-0.014243949,0.049129874,0.03500525,0.022223864,0.0041763457,-0.07654262,0.040723935,0.04549409,0.14126055,-0.011478717,0.058958944,0.026247768,-0.081263416,0.0069104135,0.061925102,-0.021031791,0.025088921,0.030151391,-0.012379564,0.015681239,-0.005381591,-0.0650058,-0.060271792,-0.02105214,-0.03559901,0.079084806,0.038132943,-0.018451855,0.06323596,-0.029226905,0.10073311,0.04349609,-0.07680358,0.048331045,0.007396163,0.013077395,0.004247261,-0.13725209,-0.0276416,-0.026122104,-0.08963855,0.006292335,0.04545968,-0.011094154,-0.033395007,-0.019833094,-0.12549327,-0.00411671,0.0022826246,0.008679812,0.04323779,-0.012043538,0.06815873,-0.04823484,0.05985637,0.047444176,0.027251936,0.060056254,-3.7292555e-08,0.086045876,-0.073543385,0.04417822,-0.041014723,0.009858194,-0.07967997,-0.03585545,0.039752696,0.010554218,-0.06160669,-0.06166482,0.053707313,-0.047824588,0.041450027,0.058428854,0.052745767,-0.05496912,-0.013440324,-0.0010123696,-0.067592576,-0.049181744,0.009758464,-0.09139425,0.009205271,-0.022635547,-0.047649074,0.036084495,0.03465236,-0.008265965,-0.06716376,-0.034677435,0.011860613,-0.011004397,0.019663975,0.0018686191,0.043774165,-0.11910341,0.03720227,0.016996628,0.102553725,0.05199859,-0.020542214,-0.08353397,0.05326181,0.057273526,0.013551217,0.05316745,-0.0068908175,0.00458744,-0.0283329,0.07044613,0.013932361,0.021360405,-0.008834641,-0.14976434,0.020864138,-0.022185791,-0.013360274,-0.05760302,-0.046236474,0.01002795,-0.0044329623,0.19863191,-0.014662368 +1.1.1.321,The enzyme from the bacterium Xanthomonas oryzae is able to reduce enantioselectively only one of the two carbonyl groups of benzil to give optically active (R)-benzoin.,384,1.0,-0.05420312,-0.025427883,-0.01464695,-0.021036882,0.08056133,0.058125168,-0.019881621,0.04696302,0.0066963686,-0.03698289,0.047856435,-0.034079563,0.033650484,0.08018107,0.0074557727,0.08792167,-0.06023293,0.06845616,-0.027118133,0.025738483,0.033411425,0.018919844,-0.008078267,0.008202717,-0.008506204,-0.030471215,0.02223149,0.0047385506,-0.012219167,-0.05564476,0.106294796,-0.0022514786,-0.018685201,-0.0516069,0.04590542,-0.037260428,-0.0040866486,-0.06732747,0.07584467,-0.03328049,-0.004084284,-0.02479039,-0.0826934,-0.0796118,-0.0011424276,-0.011570218,0.030810261,0.036809873,-0.0012944902,-0.113042735,0.009421663,0.020683499,-0.027019337,-0.0038258953,-0.053542085,0.017314345,-0.0816952,-0.030992525,-0.077937916,-0.018990345,0.10003002,0.033470556,-0.018055644,0.046857424,-0.044645194,-0.014146044,-0.004292049,-0.05627458,0.005589008,0.029369416,-0.035847288,-0.060074266,-0.00985933,-0.004165568,-0.005589785,-0.0076431227,0.05641464,-0.003861636,-0.025988907,-0.078674056,0.05312842,-0.04578016,0.007729883,0.09558002,0.0117735695,-0.040668935,0.032312863,0.026646309,0.018513724,0.043557473,0.045048967,-0.014072713,-0.004780985,-0.07593372,-0.06453879,-0.058442265,0.074738935,-0.015054806,0.026173024,0.006130825,0.027901419,0.012857537,-0.01666812,-0.085009344,-0.07276268,0.003638958,0.06163107,0.06939123,-0.031729218,-0.04089913,-0.0315459,-0.038757917,0.05936976,0.005501756,-0.10699707,0.07974169,0.06995457,0.0030714604,-0.078873515,-0.015718576,0.013428383,-0.033056248,0.017150478,0.038156446,-0.026720155,0.055756927,-0.08058329,1.5697981e-33,0.043738265,0.063070334,0.00205087,-0.12160461,0.009945652,0.06409185,-0.06818201,0.098649055,-0.10121085,-0.058016017,-0.06860942,-0.05900957,0.006629596,0.041565724,0.009321592,-0.027337564,-0.07609161,0.0808691,-0.047754087,0.009963483,0.002384796,0.025453402,-0.052987736,0.03959591,-0.012606009,0.07151537,0.035532583,0.014323515,-0.01924376,-0.032974597,-0.00756862,0.024717873,-0.14009143,0.077529185,0.006085755,0.05344241,0.004208775,-0.016402632,0.05857893,-0.02296686,0.037976503,0.104045354,-0.017448887,-0.040231537,0.024537332,0.019002024,-0.0933152,0.05707797,-0.0077985115,0.045000307,0.048376102,-0.048547976,-0.018593214,-0.005042176,0.004864081,0.016303198,-0.032010414,0.0998625,-0.0023487522,-0.07751683,-0.0056646685,-0.017043043,0.006998869,-0.0068058493,0.0015153626,0.008384404,-0.04946475,-0.02879371,-0.08762733,0.051003728,-0.08769402,0.036169622,0.11822152,0.0016533713,0.07104048,-0.060528718,-0.058215957,-0.030775487,0.07779785,0.033207487,-0.018392,-0.06926936,0.052294463,-0.08046261,-0.025570469,-0.02316531,-0.018326335,0.022320356,-0.0077551226,0.030877637,0.04672199,-0.095091455,-0.04122209,-0.020206945,-0.04774922,-3.0013152e-33,0.044986412,-0.007736839,0.109760426,0.018191747,0.015469859,0.05891425,0.001374313,-0.010658521,-0.004779534,-0.023770727,0.084995314,0.027696924,0.03962548,-0.022002196,0.013784508,0.02220323,0.07509566,0.045629054,-0.025373507,-0.048689965,-0.13624895,0.030834682,-0.010941995,-0.039607693,0.036232058,0.085191585,0.01810697,0.018460635,0.042619772,0.061636075,-0.01669638,0.04246636,-0.06549233,-0.026430782,0.058238912,0.12135311,-0.008803809,0.035288397,-0.040092465,0.085530244,-0.09814514,0.0091782445,-0.0110077495,0.09896819,0.055563927,0.034521207,-0.08679528,-0.06247565,0.015703553,-0.048606314,0.02898718,0.020706682,0.003199761,-0.0027720644,0.0003966289,0.039064188,0.039537095,-0.032278076,-0.05054317,-0.021618864,-0.023090256,-0.06302857,-0.0006382114,-0.05433244,-0.06442824,-0.004820761,-0.024913402,0.0982526,0.06783307,-0.10207091,0.06945982,-0.018176533,0.05438066,0.04563569,-0.03471603,0.058446825,-0.0075584375,-0.14196776,-0.039671566,-0.035319474,-0.0038349566,0.0018311851,0.000380717,-0.028083885,-0.033662125,-0.04578864,-0.05137092,0.065863445,-0.048879415,-0.018723235,0.010231795,0.049444005,0.08413818,0.0679436,0.14498468,-3.091688e-08,0.066638425,-0.123583816,0.042948984,-0.014235908,-0.034115173,-0.00025384894,-0.008104965,-0.018945055,0.07144847,-0.071408145,-0.021754578,0.014036368,-0.00699113,0.06305387,0.055326123,-0.027846713,-0.0033430052,0.016944718,-0.07033759,0.033166125,-0.059038654,0.022648955,-0.11731644,-0.048554294,0.0010520219,-0.052474126,0.07124807,-0.022507193,0.018314505,0.0007668622,0.023720568,0.03892192,-0.0040009273,0.09271653,-0.039666068,0.020404,-0.05173798,-0.013707733,-0.0120112505,-0.0284249,0.020315865,-0.045467354,-0.13115968,0.031132119,0.07658178,0.0058879512,0.018037416,-0.025291594,-0.048461918,0.010593582,0.023511276,0.024478579,0.011003088,-0.070610836,-0.058817614,0.07529022,-0.019469311,0.027915914,-0.01120749,-0.039711703,-0.043222956,0.036986593,0.15441747,-0.040178835 +1.1.1.322,Isolated from the plant Foeniculum vulgare (fennel). NADH is slightly preferred to NADPH.,384,1.0,-0.03198276,0.04522805,-0.09464571,0.0020178512,0.037283517,0.098445915,-0.0129919,0.063969284,0.045293592,0.011570497,0.038419172,-0.0073631825,-0.04358014,0.038476087,-0.045546386,-0.021895856,0.02502487,-0.01964949,0.028687228,0.0072188885,0.03586997,0.0984426,0.06382649,-0.02027506,0.0778894,-0.006985746,-0.04406395,0.035870884,0.026021196,-0.105794065,-0.06962335,0.04482176,-0.016546449,-0.035940215,0.0076958337,0.031712167,-0.02891206,0.016119307,0.061262507,0.09647274,-0.015388273,-0.010687366,-0.073638804,-0.050399687,-0.044289682,0.039918836,-0.02079706,0.045622826,0.059069097,0.01578299,-0.037500277,-0.013337918,-0.00065856305,0.09877336,0.06596817,-0.06632184,0.048839185,0.036490437,-0.02925875,-0.003374006,0.060601126,-0.053891283,-0.046378743,-0.013048523,-0.013926642,-0.04596365,0.0067179245,0.045288417,0.08569474,-0.092190795,-0.029376032,-0.004993043,0.08106833,0.044083532,-0.07619889,0.07087961,-0.05078776,-0.07163765,0.06123442,0.014699542,0.07623015,0.08347433,-0.04540244,0.07108876,0.043796513,0.05212256,0.013128594,0.095178775,-0.025610052,-0.026368707,-0.006254465,0.020171115,-0.026132526,0.0034098295,-0.09197926,0.0009554308,0.10016329,-0.039195877,-0.025748644,-0.0075396975,0.013257721,0.0035726978,0.04812186,-0.084281355,-0.1016272,0.03244408,-0.06907511,-0.0046115313,0.010770123,0.0053525236,-0.050351914,-0.013294929,-0.03478263,-0.045072768,-0.061141834,0.07288283,0.039455377,-0.033141464,-0.046795186,-0.051709194,-0.017339963,0.031701304,0.07871549,0.075563274,0.025659276,0.020890478,-0.092418365,-5.753467e-34,0.079530574,0.07886952,-0.02530646,0.017137349,0.019090075,-0.010563007,-0.048445728,0.041454952,-0.03319655,-0.058618147,-0.029760225,-0.06269228,-0.0060573085,-0.056290496,0.033151016,0.022421138,-0.011933803,-0.059475243,-0.018285971,-0.031050947,0.03274626,0.10568836,-0.025053276,0.012303856,0.025165612,-0.11097531,-0.027541814,-0.014060811,0.013531739,-0.024722066,0.10865899,-0.09503114,-0.017782861,0.039416183,0.03696073,0.019100986,-0.1256001,-0.09645581,-0.055359017,0.027317943,-0.026817359,0.038081784,0.0738459,-0.023180438,0.06310516,-0.08238038,-0.08313627,-0.007379092,0.052363984,0.014551163,0.042239413,0.007079353,0.08071717,-0.045369584,-0.07065468,0.005074975,-0.04340519,-0.010171007,0.007404497,0.112760596,0.054285,0.03550427,-0.041936662,0.04915223,0.0018534453,0.011665415,-0.18023437,0.027132412,0.005736842,0.049277984,0.0052160188,-0.008447437,0.06453541,-0.02019687,0.026064277,0.0072678793,-0.011119951,0.023681305,-0.0049604084,-0.027711751,0.014106128,-0.067738935,-0.06907355,0.03573828,-0.0814874,0.06421106,0.05382908,0.03335895,0.023921596,0.048664443,0.053700466,-0.029908456,-0.02492502,-0.069340095,-0.01664655,-6.0184273e-34,0.11812637,0.009392972,0.016859012,-0.057989392,-0.028279793,0.13621913,0.012995097,-0.010061183,-0.028876182,-0.03780008,-0.01808665,0.071418755,0.107970804,-0.03769464,0.045424227,-0.011304961,-0.00716629,0.07086497,0.0086692665,0.014200487,-0.069197744,0.06014735,-0.019537222,-0.037928153,0.04448678,-0.057910778,0.0028822182,0.031640757,-0.014895092,0.029832033,0.040387075,-0.032090396,-0.10990353,-0.09207637,0.006243953,0.02356629,-0.086987585,-0.08555111,-0.012106159,0.046844393,-0.06660356,-0.016698016,-0.052234042,0.03679494,0.10103272,0.021395532,-0.05941976,-0.0008426029,0.023993516,0.0018795556,0.042492907,0.002582884,-0.022845132,-0.068983056,0.032386314,-0.033757508,-0.048532598,0.049344134,0.021096416,-0.0034409317,0.059770342,-0.007919001,-0.07030066,0.008862078,0.036426328,0.039375044,-0.040214147,0.01747243,0.02630475,-0.005243509,0.066527806,0.055675656,0.040882982,0.054384276,-0.0015800457,-0.04266405,-0.027754929,-0.03264352,-0.049178634,-0.007463753,0.013830905,-0.0015915086,-0.019297544,-0.033811282,-0.0019570927,0.014927674,0.037802752,-0.011956281,-0.009918575,-0.025843441,-0.012317426,0.0151868425,-0.07654801,0.03327374,0.07590865,-2.1547867e-08,0.10435573,-0.0024076197,0.018012362,-0.04187062,-0.044353247,-0.05479164,0.10442097,-0.031862687,-0.0024919875,0.028650934,-0.056348637,0.1015297,0.04385568,0.011256072,0.03684671,-0.01748464,-0.011640054,0.048207037,-0.039576206,-0.0048601315,-0.072618246,0.0029282805,-0.079485744,0.046157535,-0.061513286,-0.024233015,0.072471045,-0.069796294,0.056829575,-0.08677828,0.06951664,0.0019674345,0.038936302,-0.07645059,-0.04749174,0.075899705,-0.031873573,0.060358517,-0.026344702,0.05074485,0.029807728,-0.12470191,0.0009816893,0.03728701,-0.05656611,-0.030517206,0.02185718,-0.029231265,-0.0153237535,-0.01716294,0.08558112,0.029825103,-0.0016609696,-0.051996022,-0.037432827,-0.02551529,-0.012607973,-0.07471376,-0.01613984,-0.0756433,-0.04133681,-0.011130431,0.14197226,0.020019006 +1.1.1.323,Isolated from the plant Tanacetum vulgare (tansy). NADH is preferred to NADPH.,384,1.0,-0.022553796,0.051699415,-0.0948071,-0.0020453474,0.019168664,0.11006445,-0.011557707,0.043884084,0.03872682,0.02071369,0.08707574,-0.01567196,-0.046200402,0.0024517584,0.003722365,0.0070218677,0.04857748,-0.010069532,0.03225484,-0.0046198424,0.02726392,0.08204627,0.053493418,-0.019435784,0.05562555,-0.018594477,-0.033990778,0.010758055,0.03750403,-0.115413845,-0.101282366,0.060340535,-0.033920776,-0.06306585,0.006984834,0.038281757,-0.048391532,-0.0021472408,0.0768402,0.08800025,-0.022040846,-0.024590874,-0.037050236,-0.061116435,-0.03347011,0.027422575,-0.013648323,0.050507527,0.09250404,0.006545904,-0.046969812,0.012264362,-0.030890752,0.06103789,0.018489633,-0.06616421,0.070859335,0.016143361,-0.043988287,-0.024306946,0.07157575,-0.03846254,-0.056639515,-0.01425519,-0.02794724,0.006107542,0.010597491,0.019022904,0.089406446,-0.10039914,-0.044035476,-0.007349327,0.022671858,0.08305606,-0.10291989,0.07262255,-0.027310895,-0.012981306,0.031139387,0.014151536,0.05465673,0.13554071,-0.020862672,0.04258495,0.054336376,0.065471046,-0.0044163605,0.10243235,-0.0043645706,-0.046217714,-0.011646873,0.03365751,-0.03816031,-0.0014114109,-0.11483331,-0.009440978,0.10251129,-0.010248946,-0.030943602,-0.005778255,0.048274033,0.031352025,0.05421681,-0.07089328,-0.11472585,0.038649816,-0.08715781,-0.051649198,0.01318613,-0.010646825,-0.07015987,-0.012972175,-0.01317873,-0.06138873,-0.047967836,0.061487652,0.022446975,-0.017114872,-0.05057007,-0.04970073,0.0093257455,7.754586e-05,0.081914656,0.03779077,0.042369176,0.016868977,-0.066124775,-5.3616244e-34,0.107486814,0.0729085,0.013381984,0.016504278,0.04149136,0.003468249,-0.019818364,0.025775174,-0.073337786,-0.039360993,-0.031829365,-0.099560864,-0.009209594,-0.059502967,0.032293584,0.03952978,-0.015973546,-0.046044417,-0.04351592,-0.05388562,-0.010727641,0.15108469,-0.0223434,0.023269681,-0.03353286,-0.0673755,-0.010554644,-0.010877195,-0.014003989,-0.005360884,0.11584877,-0.0904139,-0.0010171919,0.0020344404,0.046583965,-0.03303121,-0.13035211,-0.08162136,-0.014480893,0.033708893,-0.022235796,0.08707944,0.07937686,0.028588789,0.031725455,-0.078021124,-0.056136895,-0.0012714977,0.08770557,0.0008604994,0.018311515,0.025313297,0.07601774,7.571656e-05,-0.06918432,-0.003510552,-0.005484771,-0.011401328,-0.023712251,0.116324335,0.037341207,0.0077280174,-0.017345743,0.010265738,-0.046709694,0.035737347,-0.20221144,0.0053130155,0.026366739,0.028409138,0.022779347,-0.02554502,0.025544161,0.006079501,0.032811135,-0.024987334,0.046461288,0.018559784,-0.0077955984,-0.048535395,-0.022723792,-0.02833395,-0.057417404,0.04029233,-0.084612735,0.08489767,0.013544849,0.027810056,-0.007704718,0.03515082,0.051445622,0.038786314,-0.036753826,-0.08983616,-0.020111473,-4.0168157e-34,0.08681674,0.047512755,-0.026143033,-0.10003086,-0.012336653,0.10221979,0.0020035252,-0.016656019,0.0021782613,-0.042939767,-0.023387473,0.06586306,0.0993553,-0.0050015775,0.027173042,0.042422228,0.031367928,0.07722139,-0.0487683,-0.01306556,-0.04630146,0.05876302,0.0054568006,-0.08482335,0.04800565,-0.061499108,-0.020759325,0.051515833,0.029849822,0.01423722,0.053616002,-0.009584145,-0.1233497,-0.08058456,-0.00262142,-0.002952227,-0.06673658,-0.074644536,-0.040922478,0.0726615,-0.040068556,-0.02949045,-0.044160012,0.018594593,0.12955853,0.017155003,-0.08144873,-0.016766505,-0.02898852,0.013971371,0.058217037,-0.007660279,0.022972869,-0.02420085,0.025106467,-0.04379607,-0.057113186,0.05694215,0.0156021,-0.018093398,0.06339321,0.008386815,-0.05492746,0.004430718,0.03982471,0.017824339,-0.011846332,0.01039692,0.02724067,-0.030124152,0.048420377,0.06348535,0.02253798,0.04433737,-0.01862532,-0.029922001,-0.037687525,-0.0129214525,-0.04095096,-0.030963367,-0.022264577,0.006170324,-0.0126133645,-0.04730871,-0.01813421,0.031895302,0.047362752,-0.033893224,0.0030246396,-0.010596146,-0.052110966,0.03286678,-0.10480998,0.058276184,0.07003773,-2.0474031e-08,0.09049942,-0.038207065,-0.03208889,0.009064515,-0.04876797,0.0077711176,0.088195994,-0.018075371,-0.020150477,0.027573954,-0.027667606,0.108930774,0.052370496,0.009807087,0.013568634,0.0030197108,0.039001048,0.044341534,-0.03776235,-0.01799291,-0.051889084,0.015666973,-0.03273403,0.057887584,-0.055557124,-0.02335515,0.054791093,-0.05908477,0.057181347,-0.07996904,0.046369374,-0.010342193,0.03310681,-0.05135063,-0.010300606,0.06973771,-0.047369856,0.073672935,-0.0011703302,0.03508745,-0.017084057,-0.06508046,-0.014110149,0.06909512,-0.029597377,-0.027810434,0.039404396,-0.04644794,-0.0018026812,-0.03957625,0.06402603,0.03182727,-0.004342771,-0.030402841,-0.059395704,-0.026470432,-0.0037388538,-0.043888286,-0.038137496,-0.07368943,-0.031008784,-0.023312515,0.12142758,0.042328127 +1.1.1.324,"Contains Zn2+. The enzyme catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol. Also acts on geraniol, nerol and citronellol. May be identical to EC 1.1.1.183 geraniol dehydrogenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol as used by references 1 and 2. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}.",384,1.0,-0.10802426,0.026321111,-0.011356871,-0.014433117,0.08328755,-0.0046192897,-0.03309417,0.06761907,-0.0029547133,-0.05426981,0.02516672,-0.03960904,-0.08155481,0.012190232,-0.08325379,0.042404644,-0.07714721,0.009765795,0.03950381,-0.010839126,0.0202865,0.032000042,0.0023155087,0.048763126,0.071131274,-0.004582533,0.025592992,0.022752604,-0.012255766,0.017554464,0.059374835,0.0012092672,0.06264729,-0.03418306,-0.040150296,0.076210566,-0.008256851,-0.09012182,0.025497193,0.07651008,0.005945049,0.028338809,-0.061460104,-0.0375302,-0.0049048387,0.015393862,-0.012518103,0.014734128,-0.047499113,0.031375237,-0.065564126,-0.04329946,0.014797536,0.021463687,0.051212173,0.021798972,-0.0667249,-0.008040079,-0.06332374,0.09581336,-0.034441277,0.0007343929,-0.021487907,0.009747775,-0.08199579,0.038800254,0.043968074,-0.062410444,0.017229754,-0.04218061,-0.03488333,-0.07366199,0.081622824,-0.024683198,-0.15929085,0.028902594,0.023931934,-0.055873517,0.020986853,-0.11363779,0.020554442,0.042954642,-0.017041195,0.043507,0.069352694,0.015756184,-0.03553567,-0.019539816,0.057989664,0.12297742,0.061963007,0.00401657,-0.008962205,-0.039610326,0.015451227,0.08511275,0.04608205,0.07076531,0.02105021,0.0085180625,0.044582643,-0.0032195637,-0.019883525,-0.042008054,-0.06432883,0.006225237,0.048150953,0.023834443,-0.031159157,0.035090283,-0.01784109,-0.028236542,-0.0017792907,-0.0018325998,-0.05679827,0.055820722,0.024097884,0.010213979,-0.0076057026,0.016272817,-0.018905468,-0.015990395,0.04346748,-0.01418954,-0.05835584,0.01973758,-0.05420439,5.0936617e-33,-0.012959945,-0.013713256,-0.041087225,0.0017072851,-0.038838867,0.031234033,-0.09840193,0.092001006,-0.016507708,-0.0555387,-0.05151164,0.013763761,-0.027064724,-0.013161758,-0.061771713,-0.020837905,0.021827675,0.0068218415,0.09814035,-0.022558624,0.04343093,-0.0076847346,-0.08413213,-0.055228647,-0.05190894,0.05376003,-0.04403386,-0.062462457,-0.003925236,-0.015451303,0.009372149,-0.15422301,-0.014526616,-0.0007246731,-0.026495926,0.034603566,-0.06457611,-0.067741506,-0.09229061,0.015674291,0.028874498,0.031068081,-0.034799978,0.07050755,0.016568268,-0.034521304,-0.04621801,0.08691353,0.11907078,0.026314208,0.012398988,-0.017549057,0.020617915,-0.0008503269,-0.09321315,0.035566796,-0.02893716,0.043238588,0.08179271,0.039105006,0.031000314,0.07330751,-0.036953975,-0.05382542,0.0927975,-0.0026260526,-0.048898805,-0.011189857,-0.044804677,0.019347753,-0.047016945,-0.039183345,0.08378662,0.09927165,0.046240438,0.007334625,-0.039589897,0.02148657,0.05636256,0.014231305,-0.073468246,0.015848476,0.03256135,-0.003056599,-0.00916507,0.062962,-0.017608771,0.02257409,-0.0017186218,0.07304231,0.06745429,-0.13480155,-0.032852773,0.02420635,0.017046884,-6.1197926e-33,0.008183479,-0.052633904,0.02551733,-0.12543735,-0.050996635,0.11093377,0.022394376,-0.07837719,-0.024078736,-0.013449652,0.05589631,0.015246037,0.07891527,-0.07918077,0.015305321,-0.00879651,-0.013033485,0.065034665,0.0078725815,-0.036849376,0.05722942,0.055256926,-0.037712518,0.03921494,0.02081022,0.025777338,0.100315906,-0.026686987,0.060120653,0.11060259,-0.048520397,-0.0224823,-0.02047586,0.01208779,0.025417833,0.030250795,-0.11609,-0.027691906,-0.04647674,-0.024406293,-0.06993806,-0.006708673,0.022828054,0.06537087,0.03728,0.07492811,-0.06834463,-0.006932545,0.016277978,0.01996321,-0.008128591,0.05876907,-0.11950818,-0.017645275,0.035280198,-0.003418902,-0.0496213,-0.05573096,0.017475946,-0.09511078,0.017165458,-0.035951562,-0.015527652,0.010388251,0.00943823,0.06279114,0.026601583,0.09312156,0.0090997955,-0.06518669,0.04399955,0.0006036208,-0.011003144,-0.024173616,-0.066217385,-0.014305651,0.01538934,-0.015384364,0.01995767,-0.0814601,0.0800239,-0.013711401,-0.011183749,0.0033571133,-0.029935634,-0.024372084,0.07003374,0.08588468,0.010216301,0.013005725,0.039107084,0.06453939,-0.096930385,0.032647926,0.041713282,-4.7940134e-08,-0.049288284,-0.1485435,0.08543248,-0.036041196,0.053684305,-0.023963278,-0.009628108,0.016731635,-0.035646956,-0.037675206,0.023773497,0.07211273,-0.028755981,-0.003339242,0.029821925,-0.04438575,-0.009597374,0.096391186,-0.018683335,0.06024126,-0.059579965,-0.0028347918,-0.045065787,-0.049248617,-0.0072055045,-0.07867551,0.023456428,0.065746985,0.02761237,-0.058943935,0.0065398794,0.037468813,-0.01538753,0.01174445,0.000778481,0.04132349,-0.02523248,-0.057538517,-0.11608412,-0.036578733,-0.04974163,-0.11164167,0.049121723,0.019499993,0.028364219,0.017456109,-0.0063542062,0.0119248675,0.01767737,0.03019235,0.06341507,-0.040167965,0.051476225,-0.033913005,-0.06826171,-0.01887809,0.0035260746,-0.093278304,-0.016417313,-0.0298317,0.022046573,0.02935689,0.20479923,0.034007918 +1.1.1.325,"This enzyme, isolated from the bacterium Chlorobium tepidum, catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. cf. EC 1.1.1.153, sepiapterin reductase (L-erythro-7,8-dihydrobiopterin-forming).",384,1.0,-0.096953936,-0.048185114,-0.22349817,-0.019926187,0.09287952,0.04394621,-0.03302078,0.048922863,0.028584454,-0.04618272,-0.0033740993,-0.125011,-0.13654396,-0.025638444,-0.016499447,0.0038894007,-0.039612126,-0.04316499,0.025351813,-0.06666218,-0.02087695,0.012763288,-0.02327392,0.014602084,0.043309588,0.022965757,0.10078517,-0.08123468,-0.0037097207,0.0038992357,0.0060806437,-0.08841054,0.06921714,-0.06215738,0.06376521,0.09909306,-0.09510981,-0.07960807,0.04304553,-0.024242263,0.011960672,0.034376476,-0.072769135,-0.01911098,-0.009577344,0.033712342,-0.0056001237,0.10917802,0.032728955,-0.029009068,0.035398897,-0.04532662,-0.04494957,0.05386159,-0.006540201,0.026777526,-0.022264948,-0.03148706,0.066484116,0.06519805,0.037606254,0.008953699,0.09879046,-0.03155113,0.04231554,-0.085346706,0.019113105,-0.048677642,0.045475997,-0.090137914,-0.057059377,0.024872124,-0.04343661,0.022279404,-0.028098468,0.00891001,0.015964663,0.024207694,-0.0012094018,-0.00405593,0.046301167,0.016319651,0.026035218,0.101732194,0.052635573,-0.09274423,-0.050600097,0.045207817,0.039903414,0.023572858,0.06923719,0.05145831,0.01634824,-0.020485455,-0.037449293,0.056342084,-0.04440308,-0.021441918,0.0236667,-0.022355042,-0.03591091,0.06873104,-0.030410724,-0.07074225,-0.09692067,-0.0012137544,-0.035053525,0.091040805,0.05995361,0.008751935,0.020262564,0.012847108,0.0138180135,-0.034176815,-0.012448205,0.038621105,-0.024964035,-0.047697335,-0.029343108,0.110020496,0.030967161,-0.04032179,-0.017170198,0.08666869,-0.01563161,0.03550264,-0.08004167,2.353884e-33,0.050524022,0.042202074,-0.019463554,0.021630093,0.032233585,0.02836662,-0.031947993,0.0037479987,-0.015556604,-0.0017688813,-0.034405973,-0.13834111,0.027146831,-0.04739453,-0.028019244,-0.011126829,-0.038436215,-0.016285267,0.028152827,0.030000348,-0.01317871,0.07510091,0.017837478,-0.029438494,0.02448362,0.08095854,-0.06224224,-0.027061325,0.12959048,-0.013493184,-0.027441293,-0.08225258,-0.13724174,0.036810067,0.087214306,-0.04958771,-0.048638087,-0.062371053,-0.0076314295,0.06957443,0.023695765,0.02259041,0.006974222,-0.052023042,0.12436498,-0.0012980152,-0.014841513,0.04530145,0.077248916,0.026336228,-0.0028078747,0.00502769,0.05342364,-0.07433423,-0.07137312,-0.032717627,-0.04462169,0.058540635,0.09350826,0.027410576,0.033873715,0.093654156,-0.066568986,0.06238123,-0.026807923,-0.017115299,-0.028463187,-0.018653966,0.02068943,0.0044817645,-0.056641806,-0.035027906,0.059312392,-0.05472693,0.0034047102,-0.06100896,-0.043412536,-0.015383049,0.045247797,-0.048431803,0.0022444688,0.08957565,0.039227996,-0.033018354,-0.00592903,0.013956163,-0.084511675,-0.026448335,-0.035551406,0.042105794,-0.007601821,-0.014775717,-0.07402917,0.02118443,0.008093583,-2.4515583e-33,0.094871335,-0.11922105,0.027836984,-0.15662853,0.00038734952,0.06295858,-0.04243888,-0.030921822,0.0386484,-0.00673202,0.09469172,-0.0023362169,0.0007672081,-0.042270217,0.02887507,0.044152446,0.015490318,0.13504118,-0.054368723,-0.06925691,0.042414993,-0.015138536,0.019384729,-0.0035479676,0.018778889,0.0021077238,-0.0036330763,0.083414644,0.11556097,0.032687735,-0.028512625,-0.028035648,-0.04850991,0.03715142,-0.03442184,0.041437633,-0.07598215,-0.0298337,0.082513265,0.03363147,0.00536868,0.012336436,-0.014440169,-0.009029671,-0.0059910873,0.05969801,-0.039365735,0.04262924,-0.0017284849,0.00014817294,0.06709999,-0.05815059,-0.0631193,-0.013397871,-0.0089054825,0.015441517,0.05569106,0.0013420526,-0.01083635,-0.0444028,0.0002494843,-0.028178066,0.0357134,0.014341373,0.037917152,0.0810109,0.02769796,0.10478357,0.08548327,-0.0024140447,0.053333756,0.032682046,-0.012489009,0.029710313,0.0026142194,-0.031722065,0.0257083,-0.025217747,0.052342627,-0.029677738,0.014814836,-0.023490187,0.015329375,-0.043647364,0.047855448,-0.054741614,0.015097335,0.05039735,0.00802054,0.04747317,0.0016032523,-0.023449898,-0.0030429286,0.07072351,0.055659328,-3.324091e-08,0.06627408,-0.09431535,0.017811328,-0.068267785,0.09003243,0.012321351,0.016305793,-0.022388179,-0.06397158,-0.036432557,0.011233337,-0.0563989,0.042947393,-0.008440971,0.03163859,0.0067778723,-0.0061636483,0.022489062,0.0039061757,0.01606908,0.0033372715,0.013807372,-0.05568576,0.025939872,-0.0044950508,-0.07400354,-0.039779913,-0.02265595,0.014587441,0.013909017,0.007618406,0.007868355,-0.0014348562,0.0138412975,-0.027069544,0.025555093,-0.040570553,-0.03332798,-0.05451881,-0.029075919,-0.026196463,0.069903545,-0.044525404,-0.012759172,-0.045746535,-0.04424452,-0.022280723,0.028186219,-0.048526533,0.031748742,0.039637197,-0.015572001,0.013385412,0.012980054,-0.061852284,-0.0059410087,-0.0077114007,-0.103299946,-0.05464784,-0.077385485,0.0263475,0.034149114,0.14690019,0.012498188 +1.1.1.326,"The enzyme was cloned from shampoo ginger, Zingiber zerumbet.",384,0.99999994,-0.13356979,-0.022798413,-0.072041266,0.0022236265,0.043909047,-0.0010043206,0.04918966,0.06340779,-0.014404903,-0.06981148,0.035301108,0.034713145,-0.02135081,0.0063879415,-0.11742278,0.03595772,-0.01698229,-0.05548636,-0.043310408,-0.036513556,0.022188915,0.03989953,0.037779644,-0.03088542,0.08386186,0.007221348,0.021331262,-0.027825339,-0.028717147,-0.03779372,0.047201388,-0.017595908,-0.011134292,-0.06397326,-0.044654854,0.000101689555,-0.02660332,-0.050972387,0.057371844,0.00266032,0.038864177,-0.0061397646,-0.09032345,-0.03824511,-0.062617436,0.04716127,-0.013950889,0.016703604,0.015189437,0.0657146,-0.081834644,-0.12088282,0.023182034,-0.0094152475,0.01847496,0.0668966,-0.038207147,-0.02795685,-0.05898988,0.1045433,-0.001506787,0.031413447,-0.021122683,0.041805975,0.02636995,-0.030328581,0.008647172,-0.03642447,0.018975671,-0.08864405,-0.06328714,-0.082161985,-0.00036851363,0.02686697,-0.007340074,0.03433875,0.018572839,-0.007378834,-0.0077436767,7.043651e-05,0.010734254,-0.030122155,0.07109193,0.09580872,0.057321277,0.035261527,0.045759164,0.0018847513,0.027053606,0.013683896,0.048592865,0.043295067,-0.021668699,0.016219527,-0.035420187,-0.0011698016,-0.0740605,0.0515037,0.042626698,0.03674842,-0.018176185,-0.007150547,0.08251778,-0.10893203,-0.061195295,0.009443306,-0.016654061,0.0283325,0.017266357,0.03085008,0.019792883,-0.012970625,0.06404858,-0.043426152,-0.048757065,0.049443975,0.03159504,-0.02277045,-0.14151382,0.04435527,0.056981046,-0.04289721,0.053332455,-0.0028997983,-0.027596531,0.08469598,-0.09096934,4.8820397e-34,0.042105623,0.06903857,0.025259357,-0.014942424,0.0073920204,0.08352082,-0.010229164,0.07442244,-0.026480889,-0.06870381,-0.04097007,-0.1007004,-0.024236893,-0.027280713,-0.078990586,0.04082504,-0.016838307,-0.009268693,0.0076716766,-0.013431505,0.07058833,0.07653249,-0.08169542,-0.008303192,-0.027388036,0.038242765,-0.03952812,-0.047559705,0.056930963,-0.009554215,0.05058212,-0.06874582,-0.05462021,0.032959968,0.021986365,0.01701903,0.016694015,-0.09937356,-0.027540652,-0.00406108,0.06829457,0.040609963,0.06182642,0.021477005,0.03549496,0.0016102955,-0.13255541,0.065628625,0.075004004,0.036065966,0.01499938,-0.019561384,0.041403554,0.08313493,-0.058183137,0.06540867,-0.086690396,0.03429042,0.10623649,0.04666985,-0.020865863,0.11473088,-0.017276902,0.030292489,0.02406978,-1.0134745e-05,-0.013280754,-0.038192153,-0.03495298,0.11943931,-0.045786887,-0.043067295,0.0104902545,0.03079606,0.0073652337,-0.12807484,-0.035227016,-0.03459724,0.026198039,-0.055555224,0.007847502,0.039651606,-0.005970603,0.01138868,-0.09276568,-0.10142874,-0.08111474,0.010251865,-0.056559455,-0.0009410515,0.09548871,-0.036657907,-0.07739017,-0.015503633,-0.08655903,-1.314398e-33,0.026919516,-0.05634161,0.025173591,0.04021309,0.030902384,0.026797626,0.048197147,0.009437033,-0.043148678,-0.011905282,0.09445893,0.034236852,0.06788851,0.01055789,-0.055216182,0.06850337,0.021895228,0.052277796,-0.0068890196,-0.012523167,-0.022013752,0.086695395,0.051141385,0.022845054,-0.00061166874,0.0069849645,0.096904196,0.039155763,0.083972804,0.0443821,0.020126577,0.020694561,-0.09055306,-0.1091117,-0.048335064,0.06532208,-0.0045194533,-0.040995914,-0.006735648,-0.05792078,-0.021023324,-0.054484896,-0.0048664203,0.05891736,0.0781732,0.0209863,-0.070997134,0.018898446,0.009715264,-0.024089951,0.07067809,0.0338999,-0.02155326,0.008933883,0.013937813,-0.010994364,0.055996682,-0.081504665,-0.035171583,0.041527934,0.016482739,-0.0081762355,0.036171716,0.013471683,-0.026931806,0.03345316,0.089566626,0.080884874,-0.0029265434,-0.01935409,0.05465384,0.046474885,-0.0084410235,0.0029570619,-0.034893326,-0.0032173044,-0.08346284,0.03800753,-0.0077888025,-0.057090025,0.012751636,-0.054726183,0.036764704,-0.00436392,0.03474259,-0.08439212,0.00950894,0.07439949,0.030364664,-0.010501858,-0.036420394,-0.0008211365,-0.06496154,0.017787594,0.040495727,-2.1278266e-08,0.07061147,-0.089389816,0.094064355,-0.01839461,0.011803977,-0.004180829,0.007846903,-0.02234643,-0.070161566,0.023572143,-0.057463173,0.17736349,-0.074843146,0.08097269,0.03226391,-0.03264056,-0.023633368,0.06585574,-0.05499483,0.0126375705,-0.07534945,0.064531446,-0.082747966,-0.050647795,-0.0005010551,-0.051212225,0.02315488,0.051246606,0.011893774,-0.07434942,0.009959346,0.07495106,0.015670966,-0.04831422,-0.12363214,-0.005182505,-0.020262808,-0.0077804727,-0.02173979,-0.057006873,-0.030337434,-0.012630514,0.033004325,-0.0064248717,-0.030352302,-0.060112808,0.023402024,-0.07370127,0.03800525,-0.020386865,0.056421127,0.036273483,-0.019999143,0.0011488103,-0.017868979,-0.031877067,-0.0004653511,-0.051537957,0.03937019,-0.022465551,-0.00466842,-0.061050225,0.13381752,0.044783838 +1.3.8.3,"Contains a tightly-bound FAD cofactor. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor. ",384,1.0,-0.08148635,-0.00038648897,-0.17347774,-0.021405239,0.1291,0.053733308,-0.112968154,0.028150737,0.010840016,-0.050283518,-0.030364364,-0.06412179,-0.043521006,0.014516621,-0.06400955,-0.024842203,-0.008611879,-0.026188206,0.019948557,-0.08667608,-0.036579654,-0.002882999,0.04805729,-0.05384152,0.014216151,-0.034979664,-0.008185471,-0.008051489,-0.060168367,-0.057907067,0.06994435,0.07466019,0.034344632,-0.035983764,-0.03956577,0.12831579,-0.04993064,-0.015470606,0.06808154,0.073570706,-0.0052927467,-0.041443594,-0.0647164,-0.035711404,-0.044850197,-0.09878834,-0.03280328,0.049359374,0.016195357,0.0035927212,-0.02699299,0.03163914,-0.05403211,0.019149559,-0.0345767,0.049887266,0.039399568,-0.033690535,-0.052595805,0.004534519,0.021500977,-0.076850615,-0.01700615,0.07573963,0.012660042,-0.03812338,0.015685188,-0.07734479,0.030856373,-0.013484409,-0.040856887,-0.05699993,-0.07779375,0.0043740366,0.01478476,0.043368764,-0.007781415,-0.014424001,0.058360573,-0.07486797,0.0020378875,0.030679284,0.07254818,0.046939224,0.065854825,-0.0016061319,-0.046199527,-0.07254147,0.015225387,0.0898327,0.077816755,0.06062915,0.00574093,0.006738244,-0.051912762,0.09818041,0.11606738,0.016853731,-0.01651313,-0.048897382,0.03621111,0.017103856,-0.03799856,0.013934833,-0.075694464,-0.062222216,0.010778213,0.124938935,-0.030696353,-0.046902183,0.010343488,0.021250263,0.08826193,-0.04344829,0.012485929,0.02447431,0.057117943,-0.04709237,-0.017194165,0.01336441,-0.027530555,0.014598913,0.0076524247,0.022770308,0.046819117,-0.036582574,-0.12554398,4.2849943e-33,0.1100197,0.05558854,-0.02997622,0.007358598,-0.056062303,-0.023144525,-0.07731409,0.027550528,-0.031889834,0.049057763,-0.021188898,-0.027208628,0.03385889,-0.03600429,-0.047644384,-0.061312053,-0.03376515,0.0052452986,0.031238059,-0.028106058,0.03961562,0.06192454,0.028762773,-0.016483618,0.04583664,0.05152388,-0.014288741,0.0644661,-0.012088535,0.0123134,0.035288244,-0.055052903,-0.061969623,0.0015150682,0.00228118,-0.03167845,-0.068231896,0.011483491,-0.05880304,0.033600695,0.04229558,0.08788301,-0.01665017,-0.031918693,0.015128272,-0.0062519414,-0.04861096,0.092635475,0.056673788,0.08571003,0.05772743,-0.010930234,0.098219655,-0.023534691,-0.062863156,0.07726812,-0.02053317,0.037346795,0.0511629,0.026277779,0.010000735,0.014456393,-0.028878432,0.08724693,-0.020090988,-0.059180405,-0.07854026,-0.027114283,0.0059521697,0.07226889,-0.037370823,0.04784928,0.075340115,0.039727863,0.070998736,-0.023007248,-0.105225585,-0.07029988,0.038309325,-0.013620616,0.024094224,-0.009288557,0.042019032,-0.02324614,-0.031333596,-0.022939108,-0.07799011,-0.02845953,0.031486068,-0.007898306,0.09370522,-0.061096843,0.0044795857,-0.017868888,0.11080588,-3.338504e-33,0.12556505,-0.07195083,0.015908903,-0.07296637,0.02010378,0.069002606,0.029600402,-0.037924215,0.03952079,0.056255285,0.1211813,0.048958186,-0.0074354196,-0.096655354,0.028237212,-0.005721576,0.088351645,0.030309118,-0.00908485,-0.03193664,-0.05649398,-0.026984563,-0.00025727577,-0.041080423,0.043150634,0.04823262,-0.073569894,-0.012624333,0.008515654,0.01997864,-0.007924467,0.028456192,-0.03899251,0.005541009,-0.0254309,0.015809573,-0.060893748,0.064363085,-0.030890062,0.040483408,-0.025991617,0.001975718,0.003203066,0.0685986,0.08237191,-0.036756746,-0.10098346,-0.02566351,0.00042433152,-0.00117832,-0.03518895,-0.027966203,-0.018706838,-0.0013994531,0.07028489,0.054547157,0.052846063,-0.012725376,0.019755716,-0.029241145,-0.019066941,0.022560803,0.005530223,0.0033955933,0.0556062,0.082847625,-0.059618924,0.13279362,0.059940174,-0.0020809849,0.101808555,0.01747048,0.015476466,0.026121397,-0.01440766,-0.05634214,0.053873938,-0.003937436,-0.041749835,0.016489597,-0.0047425316,0.005815294,-0.04729175,-0.049164694,-0.07949586,-0.100335285,-0.0041336142,-0.0020007654,-0.035155747,0.0063537657,-0.0060869,-0.0029553082,0.0011105713,0.07088315,0.076894805,-3.962805e-08,-0.063305505,-0.07543272,0.003968123,-0.032315787,0.04269555,0.013023648,0.020657614,-0.05204506,0.052281793,-0.05859695,0.024218516,0.06251017,0.10220135,0.024113066,0.09334249,-0.016098948,-0.040487625,0.029625166,-0.050183427,-0.036896408,-0.046278603,0.018219857,-0.11627637,0.035592526,0.025331398,-0.03626807,-0.026700657,-0.035258874,0.06937754,0.041681346,-0.063148886,0.031969566,0.023038162,0.05337208,-0.035206497,-0.0016162586,-0.0067960913,-0.055862263,-0.05599159,0.03844084,0.033135604,0.0017328107,-0.050936226,0.007510748,0.05474605,0.023183296,-0.06976276,0.017823646,0.014786048,0.00077076413,-0.034346633,-0.016446564,-0.010588714,-0.0007220681,-0.06638397,0.054373875,-0.0130648,-0.04339351,0.016178586,-0.08989159,0.02924584,-0.024617823,0.16742986,-0.052888263 +1.3.8.4,Contains a tightly-bound FAD cofactor. Pentanoate can act as donor.,384,1.0,-0.07031717,-0.036502186,-0.026428983,-0.047232356,0.08048058,-0.034022875,0.05524156,0.054222204,0.01914644,-0.019356376,0.063266724,-0.0699663,-0.11254395,0.08341084,-0.020060714,0.0083986735,-0.09718279,-0.004721033,-0.028290972,0.06134302,0.019786678,0.011323558,0.026219137,-0.09481843,-0.0056766192,0.016293842,-0.01822359,-0.054263048,0.09216319,-0.067684636,-0.06772921,0.050931964,-0.08851815,-0.06462756,-0.0075240224,0.078631304,-0.0066158837,0.017575499,0.0030321921,0.09028754,0.058771588,-0.007998671,0.072569735,-0.020036554,0.02738442,-0.03473252,0.046597376,0.055456817,-0.009292652,0.00662503,-0.03580681,-0.04587588,-0.029811107,0.072587155,-0.006897362,0.040463805,0.03613803,-0.06827334,-0.011345872,-0.025606409,0.050468948,0.03244997,-0.020921461,-0.034373723,0.03654497,-0.022454293,0.007565549,-0.034356844,0.041428935,-0.014931756,0.059862398,0.019033533,-0.037258416,0.041494474,0.02364993,0.12437427,-0.06901474,-0.027290046,0.041797385,0.065267645,0.023671726,0.044963595,0.0853922,0.05010105,0.072813734,-0.02033355,0.03263981,-0.043138,-0.11093246,0.04604726,-0.024467263,0.043531545,-0.012475352,-0.044545177,-0.11813323,-0.005171815,-0.00089431374,0.048278254,-0.08238283,-0.0059308866,-0.00035331518,0.017399281,-0.02872784,-0.00010613131,-0.07630772,-0.05480329,-0.00567456,-0.015106001,0.034504212,0.033631682,-0.020924358,0.00018462713,0.05999355,-0.03277472,-0.060692318,0.04387729,-0.104903534,-0.058415167,0.03418814,0.003654108,-0.01619778,0.052410174,0.037714384,0.02925397,0.0016665107,-0.0006896581,-0.06727879,1.2990687e-33,0.015687088,0.037765294,0.039880197,0.020835092,-0.049200047,-0.020264825,-0.102756694,-0.060232732,-0.004843912,-0.10467325,-0.05660348,0.0030179287,-0.0030135722,0.055856362,-0.064823754,-0.014770985,-0.042081505,-0.03648632,0.046465527,-0.050846085,0.07765679,0.13782412,-0.044155367,-0.005654283,0.050074607,-0.08255634,-0.0022946778,0.047846433,-0.011955394,0.02173007,0.0008796271,-0.036575023,-0.00021466333,-0.013521658,-0.015355326,0.03466238,0.00312973,-0.13870133,-0.08936404,0.0056793047,0.046107337,-0.0070191305,0.033922467,0.030494107,0.06788107,-0.064232305,-0.029243946,-0.020368246,-0.05043044,0.024561752,0.019283831,-0.006289762,-0.065549955,0.020466441,-0.07187158,-0.06789408,-0.032811657,-0.034152765,0.015855001,0.024067743,0.0113239,0.04176856,-0.028378893,0.044519767,-0.08442915,0.08155798,-0.037549663,-0.07654915,-0.0035447034,0.02205161,-0.06187591,-0.029018097,-0.010301798,0.032128382,0.0026509773,-0.068960905,0.03609556,0.0016436992,0.035101824,0.0006031459,-0.0052635786,-0.07531429,0.0077988305,-0.01564568,-0.10980677,-0.08610808,0.011231761,-0.07074039,0.052092463,-0.07507879,0.044002995,-0.009411777,-0.051187046,-0.06524143,4.8318296e-05,-1.2763691e-33,0.027177354,-0.12560025,0.07126036,0.01794324,-0.0006784275,0.07359809,0.056656454,-0.03339496,0.10833467,-0.029940795,-0.020397233,0.041215934,0.058495555,-0.01076139,0.0138391,-0.0041133906,-0.0040019504,0.040770248,0.05793634,-0.0272504,-0.06166239,0.045416888,0.038554054,0.071718015,0.0014336366,0.06174533,-0.049041044,-0.070235185,-0.003087364,0.021830292,0.04207858,-0.028770132,-0.097869106,0.033858012,-0.13350427,-0.011102442,0.075320825,-0.036913887,-0.081274904,-0.0045886636,-0.036124367,-0.07468525,0.013695719,0.09315638,-0.009613841,-0.03163333,0.0011784072,0.016333725,0.047978155,-0.016145047,0.035483856,0.037549745,0.02540491,-0.027940834,0.046583906,0.013642714,0.071105964,-0.05289008,0.035082687,0.026504735,0.04569714,0.021105545,0.0119071165,0.018016348,0.12703313,0.014013781,0.029472033,0.14638528,-0.0047441158,0.043473467,0.093950056,0.11199678,0.076212265,0.013392155,0.063737966,0.04734119,-0.03623186,-0.028022405,0.02686519,-0.011418339,-0.03561701,-0.0570325,0.025595598,0.03295618,0.0025120166,-0.030727338,0.052977584,0.032901414,0.009886039,0.047527365,-0.06687138,-0.0067219813,0.016515458,0.056097206,0.12508343,-2.3669884e-08,0.034596026,0.04409897,-0.0067324387,-0.015184918,-0.064588346,-0.019669058,0.021888724,-0.0112226745,0.043315455,0.038844153,-0.054602366,0.111076005,0.03440266,0.024012223,0.043528374,0.028491776,-0.01562567,-0.02560369,-0.051407874,-0.020993805,-0.07084652,0.0118751535,-0.036016848,-0.0022738806,-0.07497045,-0.011195289,0.086694404,0.10196315,-0.056215767,0.04406161,-0.01137715,-0.043073848,-0.048505202,-0.016811237,-0.03815846,0.07192865,0.02671066,-0.058077525,-0.0660524,0.034256447,-0.008111566,-0.030477379,-0.05981393,0.0006165615,0.02025431,0.01929131,0.01638502,-0.006421326,-0.03924239,-0.0062107104,0.049214013,-0.0067357426,0.027731242,0.0146731045,-0.0851226,-0.021090746,-0.023330739,0.03491182,0.074013814,-0.061909076,0.0024086873,0.016531752,0.18981661,0.05787706 +1.3.99.32,"The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.",384,1.0,-0.0751715,-0.06636246,-0.04975304,-0.09106556,0.05329129,-0.035786696,-0.16982608,0.0015269978,0.041469578,-0.02437097,-0.0011573088,-0.07574772,-0.085952014,-0.0037307893,-0.045520023,-0.03034247,-0.084003046,-0.0023879902,-0.01543878,-0.045461867,0.061818443,0.020708427,-0.06435776,-0.014645129,0.049328893,0.028648052,0.019956538,-0.0070686196,-0.08055708,-0.05438519,0.033979956,-0.025450246,0.02528397,0.03262343,0.007629509,0.090912506,0.0029151586,-0.026222192,0.07873745,0.0042547258,-0.027560096,0.03886994,-0.010801367,-0.032061152,-0.004491509,-0.017138222,-0.036217954,0.030064778,0.009682187,-0.05378368,0.012916555,-0.023048403,-0.066613935,0.0346736,0.0215221,-0.014074053,0.01697961,-0.014631957,-0.046548292,-0.017909817,0.0021693523,0.0061192666,-0.007515994,-0.0070530446,0.032629997,-0.045488905,0.07055703,-0.06758171,0.019676894,-0.04625234,-0.05637164,-0.058422066,0.0056956112,-0.0025846998,-0.04073481,0.048235007,-0.03569081,-0.05105913,0.08735701,-0.069300406,0.058150664,0.038255163,0.05855993,0.071872644,0.042592116,-0.060772773,0.0019134671,-0.030409176,0.016918732,0.02345672,0.09597761,0.0044986615,-0.026898382,-0.016277125,-0.09648731,0.032877605,0.021861654,0.09672031,0.011350474,-0.04014107,-0.026544295,0.033695612,0.020859271,-0.026800754,-0.017361367,-0.0328772,0.034301393,0.12310369,-0.0068675536,-0.0046681464,-0.04319043,0.056508984,0.009300384,0.02770545,-0.061358828,0.05210524,0.06893509,-0.08673868,-0.034689188,0.0048159063,-0.0031526,-0.03364146,0.10846909,0.059940197,0.017516457,0.049225986,-0.11644559,1.6740375e-33,0.087384276,-0.046729952,0.015920952,-0.06379981,0.012699837,0.0049118004,-0.124523915,0.13953406,-0.007045984,-0.021048373,-0.049660426,0.0047068773,0.05805604,0.04109909,-0.042220425,-0.004948867,-0.037066564,-0.033924174,0.061208524,-0.03414178,-0.0004548764,0.112538286,-0.017482854,0.020084566,0.023812067,0.014787835,-0.016599406,0.04942144,0.0107101295,0.014502832,0.0373971,-0.1667319,-0.04836933,0.05314593,0.053585455,0.04872442,-0.09604325,0.002891513,-0.06894744,0.02912558,0.040717702,0.023147253,0.046399742,-0.086109586,0.032139678,-0.05656718,-0.04451896,0.07609683,-0.06417453,0.077037275,0.06834787,0.02917037,0.05162695,-0.023606826,-0.04906982,0.06703089,-0.006539889,0.0036245133,0.070654355,0.055714212,0.036340605,0.085562706,-0.047704857,0.031182306,0.060994808,0.005903654,-0.056490216,-0.015100701,0.029187642,0.14886224,-0.046030495,-0.039357077,0.07562784,0.054156177,0.005920451,-0.03938662,-6.1016064e-05,-0.03151197,0.005670553,-0.034335583,-0.046095602,0.008846221,0.0072565586,-0.05182254,-0.08334569,0.050256304,-0.06593933,-0.033747807,-0.009647409,0.049720816,-0.02594234,-0.057222128,-0.06282421,-0.0026412841,0.07650947,-2.9598367e-33,0.100630894,-0.09401217,0.012053366,-0.09519215,-0.011785835,0.12391466,0.06900617,-0.062223773,0.031520415,-0.0076470613,0.10016967,0.014365068,-0.012374954,-0.019547518,0.06058229,0.042528514,-0.00893785,-0.0029861727,-0.006033055,0.0041382494,0.027679475,0.12518907,0.06321167,0.014223087,0.048811227,-0.049342122,0.001852935,0.05090126,0.03772341,0.0024678544,0.023170376,0.032994196,0.0095429765,-0.012595266,-0.08906863,0.020741679,-0.09071731,-0.0035841602,-0.020020839,0.02476143,-0.0057948837,0.01850537,0.0030711927,0.10464848,0.05690563,0.03182398,-0.09920477,-0.008908909,0.033979088,-0.029169269,0.013520296,-0.052919857,-0.012701223,-0.0052703526,0.0650582,0.055847894,0.030351136,-0.0075048413,-0.047607798,0.0053552506,-0.02880832,-0.04246815,0.009153799,-0.06932747,0.05462355,0.010635683,-0.01685407,0.0115959,0.03138277,-0.026824128,0.07434297,0.009381547,-0.04341784,-2.4619767e-05,-0.08240555,-0.054469492,-0.054850135,0.028206468,0.015403302,-0.016879026,0.018208323,0.01892824,-0.023442268,0.02706161,-0.069213495,-0.07767031,-0.015472064,0.116790935,-0.008091072,0.05630454,-0.010775934,0.04092227,-0.009764412,0.02607812,0.029038588,-4.009457e-08,0.03597574,-0.045894407,0.04917397,0.008296119,0.009897825,0.037572928,-0.014397102,-0.00059518014,-0.0024683028,-0.005322779,0.01819999,0.095688775,-0.07824708,-0.004445847,0.007142386,0.008219743,-0.09624674,-0.010953425,-0.032177176,0.012381785,-0.067211665,0.0019409789,-0.12076076,0.06865152,0.025984408,-0.033404853,0.03128992,-0.04622859,-0.010375682,0.023495927,0.00982185,0.033339404,0.012017521,-0.0914107,-0.03751089,-0.013805384,-0.013697067,-0.032264862,-0.038349185,0.0632452,0.061239235,0.006495853,-0.06500991,-0.0013784386,0.034726977,0.031249648,0.0006651005,0.029537564,-0.049957737,0.051001426,0.06132451,-0.00587551,-0.01130058,0.037714794,-0.10108643,0.009599645,-0.025569268,-0.13127784,0.01793936,0.020678988,0.09877025,-0.021959076,0.15542813,0.01375525 +1.14.13.150,Requires cytochrome P-450. The recommended numbering of humulene gives 10-hydroxy-alpha-humulene as the product rather than 8-hydroxy-alpha-humulene as used by the reference. See {iupac/sectionF/index::Section F: Natural Product Nomenclature}.,384,0.99999994,-0.005101206,-0.018651402,0.0046696966,-0.08083776,0.02165976,0.013488746,-0.025267009,0.066883035,0.031805493,-0.03557554,0.020659478,-0.04626111,-0.026701946,0.047698587,-0.079733185,-0.015553259,-0.013299707,-0.060649846,0.024555136,0.0017392439,0.016596096,0.0466828,0.12007698,0.02520874,-0.08593189,-0.00501018,-0.04570522,0.042282924,0.0061647925,-0.05945292,0.0064374884,0.07708185,0.09617786,-0.053876482,0.0050681606,0.033384535,-0.049157716,0.002698845,0.02844542,0.0071635866,0.092462935,-0.14437507,-0.00029165682,0.04093454,-0.019465396,-0.08291176,-0.019952899,0.0035598953,0.08207939,0.09398456,-0.017266678,-0.037176315,-0.09572467,0.062996075,-0.003769096,-0.03373824,-0.032422706,-0.03864769,-0.018460045,0.013160767,-0.049632054,0.026643299,-0.0009594698,-0.021995729,0.06740918,-0.016713794,-0.036205925,-0.10484351,-0.05287806,0.038416807,0.039740946,-0.10820403,-0.034238346,0.083186544,-0.08673086,0.13422778,0.01377198,-0.029889999,0.054077685,-0.07406495,-0.05726654,0.0125564765,-0.051151432,0.04087246,0.041187014,0.02789763,-0.04907152,0.007039498,-0.058602445,-0.047177035,0.040349014,-0.00073902495,-0.03307343,0.0080858385,-0.012683749,0.03361006,0.028860033,0.086731456,-0.030675778,-0.008425896,0.050297808,-0.024995724,-0.08761086,-0.1268331,-0.13001405,-0.011469792,0.019201895,-0.076070845,0.005365522,-0.076412864,-0.07450108,-0.012222179,-0.06399108,-0.0111016305,-0.0064266515,0.040946778,0.028309533,0.0066422154,0.03314577,-0.05260691,-0.06090123,-0.043962173,0.059787214,0.0029817712,-0.0433081,8.583944e-05,-0.078054346,3.649325e-33,0.016344491,-0.013310595,0.071988955,0.03879466,-0.025695672,0.03314319,-0.079347655,-0.0313992,-0.030449934,-0.018782007,-0.07534388,-0.009711762,-0.048258025,0.010737136,-0.07445562,0.0002873941,0.0008834504,-0.016735474,0.012551823,-0.085083455,0.013225517,0.04371415,0.023711266,0.026494656,-0.028654227,0.054646473,0.032969713,-0.032651976,0.075517386,-0.0030811597,0.03075512,-0.061863948,-0.021538166,-0.05963185,-0.031126427,0.028825305,-0.073267825,0.008458934,-0.041493975,0.06694851,0.036064245,-0.024278726,0.028517531,-0.006193311,0.08250819,0.021277787,-0.06871438,0.058075037,0.041097436,0.029810492,0.028747058,0.010409402,0.04510208,-0.010120196,-0.051452287,-0.010754342,0.0034424912,0.018760115,-0.005630667,0.027381122,0.05858209,0.06937897,0.0333796,0.04933331,0.04233758,0.08970476,-0.08951124,0.0546253,-0.01481221,0.124096274,0.0448857,0.06595119,0.06476476,0.021566134,0.09822271,0.0048168264,-0.039976504,0.07582469,0.055981617,-0.025119834,-0.035005335,0.037676938,0.029975101,0.0722948,-0.04851545,0.021455942,0.014466727,0.07499112,0.01766362,0.0939991,0.04107966,-0.025089046,-0.041031957,-0.018345729,-0.06710273,-3.8908183e-33,0.009783913,-0.05115592,0.048530273,-0.021674685,0.015061108,0.017773226,0.09576751,-0.07553065,0.05344079,-0.001437316,0.1316084,-0.0001444765,0.0037390871,-0.10313195,0.020867031,0.05177054,-0.06714704,0.028667113,-0.0252557,0.02575049,-0.06718438,0.044377852,-0.014100773,0.07989445,-0.013348977,0.024224475,0.037583955,-0.0020143008,0.09943802,-0.035088785,-0.08482392,0.082610376,-0.059200093,-0.047083598,0.0029470492,-0.018020503,0.02252601,-0.042303577,-0.076051585,-0.0003476964,-0.09671594,0.064669654,-0.010989344,0.014770547,0.030876992,0.04524719,-0.01606076,-0.061366376,-0.0545415,0.044943612,0.06256463,-0.055079956,0.0033943641,-0.012500635,0.048672073,0.051195063,-0.07102992,0.05644542,0.06459738,0.010715326,-0.015599919,-0.01382338,-0.02094066,-0.07509918,0.009511485,0.021794995,-0.061044373,0.06965348,-0.01926756,0.009434182,0.02778012,0.026658269,0.06158636,0.042081732,-0.02463755,0.03985203,0.04737181,0.018442322,0.074497916,-0.0527427,-0.046539124,0.0057685776,-0.100360624,0.019374758,0.03219744,-0.017406628,0.022543838,0.03829721,0.032157023,0.032838564,0.015665645,0.013965828,-0.08925669,0.061223827,0.09389014,-4.338317e-08,0.026045408,-0.07023493,0.045452558,0.0078075896,0.09748883,0.018286508,0.00026364694,-0.0047038617,0.04377269,-0.038139872,-0.007593421,-0.0024530503,0.050285086,0.025169032,-0.04260876,-0.07915549,0.030316956,0.038981568,0.0031542906,-0.034810565,-0.13662156,0.014646825,-0.06321254,0.025860226,0.014300141,-0.073561855,0.011356669,-0.011808498,-0.0063941167,-0.026933836,0.06472717,0.012149458,-0.037546728,-0.10026222,0.018289281,0.07982239,-0.0049288557,-0.009800686,0.03515469,-0.0015297332,-0.055475574,-0.06668302,-0.0058029,-0.044479918,0.008700591,-0.07071651,-0.050831176,0.024052866,-0.053309493,0.04040348,0.012751753,0.03410195,0.018593391,-0.122807585,-0.039663766,0.009614409,0.060491294,-0.055214908,-0.03855041,-0.08319248,0.06981253,-0.052771926,0.14951918,-0.02157635 +1.14.13.151,A heme-thiolate protein (P-450). The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain.,384,1.0,-0.07452689,0.01920769,-0.03845104,0.03135345,0.07708393,0.034320436,-0.011248751,0.09403625,-0.026503403,-0.07729768,-0.017601531,-0.06633453,-0.058217306,0.036617283,-0.032898843,-0.017342933,-0.05656732,-0.004663756,0.01846553,-0.014181282,-0.036366444,0.038744833,0.030854858,-0.056947507,-0.02860481,0.07233837,0.057917763,0.07907777,-0.025805008,-0.072902784,-0.027903825,0.015847616,0.011227551,0.0045786123,-0.0010287524,0.100751325,-0.04500826,-0.037305642,0.040983457,-0.08016164,0.055985656,-0.04971155,-0.007253737,-0.021940548,-0.05147878,-0.010968129,0.049966328,0.010681655,0.043376766,0.013285521,-7.154946e-06,-0.027534703,-0.01105835,0.09354463,0.027718192,0.010764614,0.054139752,-0.013285384,-0.015028041,-0.053884793,-0.0009437509,0.009078338,-0.023414949,0.049162187,0.015924588,-0.066842794,0.028663402,-0.045953162,-0.0742408,-0.0595976,0.025977353,0.0012706618,0.042327687,0.014040696,0.017467393,0.073827565,0.0072651505,-0.018634954,0.056622803,0.007826662,-0.0029736506,-0.02482696,0.008939706,0.11202377,-0.0060733566,-0.022808544,-0.062567405,0.020598806,-0.1298765,-0.005587583,0.0049943477,0.05327712,0.02299179,0.0053013787,-0.07905425,0.054089546,-0.008991777,0.021348799,0.046084404,0.0051579042,-0.050373312,0.07332642,-0.0037175105,-0.08693085,-0.005842748,-0.048040304,-0.0400306,0.053828835,0.113014705,-0.047680747,0.038893458,-0.008156432,0.088243224,-0.023572082,0.030079762,0.10957325,-0.003988419,0.005390982,0.005185556,-0.03008888,0.01607425,-0.022561038,0.026628664,-0.0026915127,-0.07645393,-0.03774239,-0.14707686,-4.708133e-34,0.079221986,0.009517074,0.008250666,0.026463939,-0.008999516,-0.024097092,-0.09005792,-0.026530078,-0.030437972,-0.014769459,-0.09988676,-0.11404874,0.09965292,-0.07065352,-0.053729024,-0.10901061,-0.09038933,0.020999543,0.063550994,0.008470693,0.023767222,0.076990925,0.025436662,0.035815146,0.091594465,0.08416576,0.0044825054,0.005050313,0.038600687,0.013101382,0.017859757,-0.01626255,-0.062790886,-0.060000986,0.009471843,-0.0523399,0.019473635,-0.001289143,-0.06044819,-0.007864867,0.027339498,0.024473201,0.0022068557,-0.082723364,0.094177656,-0.11279548,-0.05636231,0.02203504,0.0105297435,0.08570882,0.034529597,-0.09117381,0.07411165,0.01627119,-0.051845096,-0.010116688,0.010606611,0.06972115,0.046804123,0.06530029,0.10545881,0.08574963,0.00492547,0.03265393,-0.0067209904,0.06605079,0.012828941,-0.023917342,-0.026384562,0.119851775,-0.011983338,0.039284144,0.07291518,-0.070980825,0.07493789,-0.054952223,-0.05977356,-0.0023550852,0.13715243,-0.010181604,0.024204304,-0.027513878,-0.024625523,-0.022589812,-0.058176294,-0.028478943,-0.0277855,-0.008806496,-0.025130583,0.044459082,0.0820252,-0.06714776,-0.07350691,-0.050081342,-0.030086756,1.433407e-34,0.048978586,-0.07673375,0.040050246,-0.046658855,-0.036796197,0.050085567,0.03215777,-0.024727387,-0.018474292,0.04590308,0.16681446,-0.013948151,0.039725877,-0.06805833,0.025313959,0.02600366,-0.09536796,-0.03969756,0.05730277,0.02540852,0.059757177,-0.009395295,0.0026632575,-0.00086094916,0.06572773,0.02611189,-0.04906937,0.003647133,0.11750784,-0.00084286835,-0.032519825,-0.022882855,-0.084505856,-0.046710912,-0.04112759,0.03060937,0.0028268097,0.016154172,0.03453955,-0.01485423,-0.022943038,0.041226808,0.049561433,0.10997241,0.027528984,0.08434092,-0.038124967,-0.03166433,0.027813092,-0.022732152,-0.04360565,0.0013779309,-0.06220014,0.0075368225,-0.05207463,-0.0053205956,0.030227477,0.04481777,-0.016237296,-0.03883889,-0.025548406,-0.072013415,0.05093355,0.108127,0.003255111,0.06330837,-0.058814365,0.073545575,0.01705179,0.013265423,0.043738622,-0.014420817,0.069416754,0.004722428,0.0043871324,-0.01477642,0.03862356,0.015615289,0.062140726,0.030827694,-0.018495437,0.023162002,-0.04761387,-3.397578e-05,0.03265658,-0.099178076,0.019990375,0.064901836,0.014417673,-0.027088625,-0.0650917,0.07064245,0.0054407823,-0.022545364,0.04399982,-2.8199437e-08,-0.07118502,-0.12110682,0.00374253,-0.019644558,0.06718057,0.0007290789,-0.03194058,-0.012311743,0.045662858,-0.0107465265,-0.010696051,0.098082125,-0.007835412,-0.053744614,0.011920696,-0.0075798766,-0.0069755954,-0.01866796,0.009657541,-0.012832528,-0.04917229,-0.0034954252,-0.061220646,0.014467698,0.008991448,-0.04414959,-0.05112833,-0.08369857,0.010798002,-0.06331992,-0.046795554,0.066212855,-0.07546397,-0.031693097,-0.014711588,0.013450018,-0.08018247,-0.02329315,-0.035229784,-0.0010849478,0.017132146,-0.04017533,-0.055795442,-0.021545647,0.0032595203,0.046941664,0.031842135,0.014338066,-0.03695929,-0.062887974,0.046602637,-0.052437697,0.024369944,-0.061177347,-0.1318961,0.10967597,0.006718196,0.0068792426,0.07254588,-0.037409373,-0.01111253,0.020042451,0.12278803,0.0017890107 +1.14.13.152,"Requires cytochrome P-450. Also hydroxylates nerol and citronellol, cf. EC 1.14.13.151 linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}. The cloned enzyme also catalysed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.13.21, flavonoid 3'-monooxygenase) [3].",384,0.99999994,-0.0747563,-0.002827047,-0.08698145,-0.007863655,0.05251074,0.016063837,-0.06569675,0.03781891,0.014593242,-0.083144136,-0.01561597,-0.031321593,-0.030191178,0.010402752,-0.08770832,0.03169035,-0.036070228,0.055328157,-0.023842707,-0.04938935,0.010172612,-0.013782306,0.045867644,0.056990318,0.059925213,-0.05668744,0.022309907,-0.031885024,-0.035361525,-0.012519971,0.07333796,0.009586424,0.036557022,-0.03044943,-0.07737225,0.07154369,-0.07257373,-0.061987113,0.011619965,0.021436963,0.029841872,-0.020142362,-0.030952463,0.0041353228,0.0061026327,-0.047892585,-0.08625196,0.007013667,0.05355636,0.006295284,-0.062228072,-0.02052351,-0.01743018,-0.007833494,0.03539232,-0.024919074,-0.04788433,-0.06529965,-0.024572955,0.11321361,0.009421092,-0.008445925,-0.026262373,0.021412926,-0.07865459,0.05570867,-0.0037165817,-0.03766012,0.011861428,-0.030964846,0.024645763,-0.06513484,0.05433938,0.014918837,-0.12435634,0.056730047,0.053934317,0.016660517,0.03428925,-0.035267793,0.019851757,0.054858074,-0.009330453,0.07307205,0.07062498,0.052707724,-0.08246029,0.035170272,0.0053267768,0.11866358,0.03895781,0.055102356,-0.0004648602,-0.009540552,-0.018257348,0.07019828,0.031208506,-0.006647196,-0.07438868,-0.0063527278,0.012747012,0.0009971376,0.03473507,-0.007665253,-0.11889669,-0.006122024,0.045042224,0.011737181,-0.025625862,0.026596682,0.01753129,-0.056983773,-0.0014921998,-0.041633964,-0.035878837,0.10662414,0.021379001,-0.030281868,-0.019778967,-0.015946105,-0.032817844,-0.0027615651,0.028778968,-0.01714687,-0.050877158,0.007463495,0.010486539,7.0236794e-33,0.019983424,0.03749198,-0.06482609,0.04277314,-0.04145932,0.022623187,-0.09825875,0.025915062,-0.046349633,-0.057807166,-0.04981981,0.013656698,-0.044075187,-0.008079819,-0.05514169,-0.029719934,0.020761948,-0.01155827,0.065580785,-0.04319137,0.0014645573,-0.04306803,-0.09395612,-0.024229338,-0.08442195,0.04568648,-0.02933115,-0.06448187,0.033939645,-0.0021479344,0.0067879814,-0.07687566,0.020908969,0.056484435,-0.07835988,0.030551638,-0.07929843,-0.062120058,-0.08531458,0.119393714,-0.016078316,0.062473245,0.029659845,-0.009357219,0.07315812,-0.045529235,-0.0826184,0.12287656,0.07285442,0.08025124,0.044690743,0.035744186,0.014531069,0.046282765,-0.073219866,0.04823954,0.018525075,0.014021464,0.09085244,0.015191929,0.016781844,0.047577523,0.009933012,-0.010569502,0.10291369,0.035802376,-0.03688397,-0.018734569,-0.011609988,0.05437476,-0.018026212,-0.036297377,0.043000113,0.08301849,0.08813453,0.01464921,-0.022102576,0.0016197182,0.047513783,0.023624605,-0.032334317,0.033902418,0.03808195,0.07217636,0.042908832,0.039834853,-0.017406957,0.037462093,0.01453203,0.05324176,0.08203399,-0.096698165,-0.011632888,0.048346292,-0.03995995,-5.647627e-33,0.10488868,-0.107009046,0.022585154,-0.068858035,-0.017693829,0.07707691,0.031539857,-0.098854676,-0.019148659,0.024147036,0.11812687,-0.041929018,0.049480136,-0.044321503,0.016188376,-0.005471088,0.066464804,0.03729569,-0.036716495,-0.0043479484,0.013838897,0.06509467,-0.036201715,0.03836491,0.008295899,-0.024261124,0.06717379,-0.050907977,0.040486597,0.07499262,-0.092286944,-0.01078748,-0.04997267,0.0033171528,0.0726306,0.079648644,-0.017705228,0.01217845,-0.03847686,-0.03471568,-0.05752651,0.058610547,-0.032673616,0.037323274,0.022021959,0.09905128,-0.08306101,-0.009477372,0.038639203,0.0023435194,-0.01998151,0.06003896,-0.054577198,0.017540919,0.0115845,-0.018794345,0.023808269,-0.037832845,0.010737459,-0.1032874,-0.052612275,-0.05574861,0.023233915,-0.044241358,0.01539585,0.10219599,-0.0051308908,0.12815328,-0.009125343,-0.06715132,0.002688685,-0.013624186,0.057150967,0.043694556,-0.039970517,-0.030779168,0.03772598,0.001731663,0.03958823,-0.06296502,0.09758488,-0.013547587,-0.010951252,-0.05626995,-0.017101606,-0.06905249,0.04324246,0.04811917,0.057113584,0.0060094856,0.04549022,0.076890476,-0.13110651,-0.020822696,0.109455794,-4.843425e-08,-0.044752557,-0.0574891,0.050399676,-0.0067426576,0.07327651,0.038777776,-0.025544042,-0.018538373,-0.022781232,-0.060242113,-0.018200131,0.08851237,-0.040712398,0.0013045194,0.009901707,-0.049250167,0.01845392,0.06403858,0.01518128,0.015893495,-0.07319517,0.028679036,-0.061053477,-0.08532154,-0.028762769,-0.10046031,-0.0317282,0.013117349,0.10755274,-0.02874295,0.017967198,0.030769981,-0.029801454,-0.018114628,-0.03251477,0.018417675,-0.033241656,-0.006281991,-0.023481468,-0.04834302,-0.053257354,-0.0682322,0.01761189,0.0042905128,0.013968841,-0.030238794,-0.013475955,-0.017187992,-0.003519105,0.021628529,0.08824855,-0.03944033,0.08909437,-0.052411705,-0.055230435,-0.041762877,0.03719774,-0.08846998,-0.05757113,-0.06791685,0.00201227,-0.011860092,0.17319746,0.050225195 +1.14.13.153,Requires cytochrome P-450. The enzyme has been characterized from Salvia officinalis (sage).,384,1.0,-0.032997634,-0.0058132,-0.047769483,-0.0008551718,0.088039756,0.06422369,-0.052850217,0.047359183,-0.008466255,0.0023112553,0.009590819,0.030994475,-0.053187944,0.050725784,-0.0029514676,0.05587887,0.009366611,-0.058319394,-0.015659269,-0.013440062,0.09149229,0.014762366,0.048309933,-0.0049558273,0.016143674,-0.012253352,0.011620538,0.08454853,-0.038558215,-0.045753475,0.054088835,0.007992244,0.057338662,-0.07368273,-0.021911794,0.060244426,-0.10139365,-0.017153818,0.04226239,0.0131293805,0.065827034,-0.07497635,-0.109123826,0.060126334,0.01622482,-0.107774876,-0.0142449755,0.01798045,0.10384524,-0.039672848,-0.09106142,-0.0743306,-0.03515087,0.0011590787,-0.038237277,0.0227654,-0.0066623534,-0.06443181,0.004038367,-0.046244472,-0.03917739,0.04015539,-0.027469628,-0.024556004,-0.0036433034,0.005532055,0.024834655,-0.106950775,0.026045693,-0.06391553,-0.058958746,-0.08669558,-0.068618216,0.07014315,-0.0776751,0.0034334413,-0.015583542,-0.014917733,-0.021212125,-0.01212238,-0.00039644167,0.04364757,-0.030916631,0.10182763,0.10067395,0.048656873,0.031604253,0.038996518,-0.023847334,-0.052293018,-0.016642569,-0.0062539964,-0.03420329,-0.0067561404,-0.071225755,0.021486573,-0.0049590305,-5.3455722e-05,-0.026904412,0.0016119749,0.06795948,0.040357362,-0.03788626,-0.09726219,-0.06525477,0.045583185,-0.03904538,-0.0071054124,0.021727566,-0.1174168,-0.030878477,-0.01334963,-0.028579837,-0.049297836,0.03491737,0.06939889,0.011208445,-0.0011071012,-0.060808238,0.0046718884,0.0039862003,-0.030709242,0.032922205,0.006264234,-0.024211165,0.0798455,-0.052915063,1.9180896e-33,0.054863118,0.0066160304,-0.013125855,0.053975604,-0.027297197,0.010610905,-0.06832336,0.056338392,-0.020941628,-0.07483689,-0.038304217,-0.102457084,-0.025819123,-0.022451814,0.02933158,0.029272577,0.061812934,-0.032437567,0.073571146,0.0054554255,-0.09304858,-0.0073213074,-0.014425142,-0.01217727,-0.018703137,0.10893247,0.024924072,-0.01248034,0.090485096,0.008216656,0.051650867,-0.039732404,-0.05019519,-0.0022348315,0.018928282,0.02108529,-0.0123249395,-0.043482494,-0.0027978567,0.04583731,-0.049835604,0.032610003,0.05938724,0.012064636,0.07302835,-0.037202913,-0.105172954,0.059690084,0.062402613,0.027930127,0.012251249,0.0193532,0.122181594,0.07956046,-0.068861865,-0.013777022,0.023837028,0.040257897,-0.039770957,0.00925268,0.03220934,0.011470119,-0.037991185,0.068207525,0.005986315,0.062471963,-0.06519496,0.012424352,-0.007870749,0.12192423,-0.023791432,0.066194646,0.003054686,0.028110683,0.012232234,-0.041771453,-0.0029402433,0.097350426,0.10596112,0.010917793,-0.021279017,0.022378452,0.013711583,0.044127006,-0.040517785,-0.05625474,-0.010300623,-0.0077887867,-0.017280148,0.02171767,0.07512326,-0.03730019,-0.04722988,-0.0030404942,-0.038590353,-1.2381055e-33,0.07566755,-0.06988077,0.00080768985,-0.0028558222,-0.05477472,0.10334963,0.01700324,-0.040604822,-0.050057184,0.02622404,0.06814527,-0.07688999,-0.0029478753,-0.054433182,0.015017738,0.014838656,-0.047101717,0.09505093,-0.039889053,0.026762545,-0.025135925,0.038134363,0.06134028,-0.020158231,0.036547,0.054117844,0.008218786,-0.019104214,0.012628306,-0.021159757,-0.000982353,0.070723176,-0.1187177,-0.09934894,-0.050376076,0.04070954,-0.008632441,0.009577878,-0.024567122,0.06284226,-0.020169163,0.09426379,0.026159687,0.03693062,0.029274354,0.07650351,-0.042782996,0.0073327306,-0.04254086,-0.060816884,0.07981226,0.0028067927,0.0037909294,0.017304754,-0.0045857485,0.008443394,-0.009739555,-0.027678857,0.013536978,-0.08449534,0.00011952677,0.010752641,-0.040600285,0.06356909,0.024156662,0.04774795,0.056399856,0.09652938,-0.019961953,-0.014995224,0.005228368,-0.031803083,0.07588617,0.082050934,-0.03783241,0.09658927,-0.019793648,-0.005950817,0.08137825,-0.007331025,0.0035173013,-0.052537993,-0.06995245,-0.035473622,-0.025640607,-0.08857331,-0.019961743,0.01021056,0.024357859,-0.033230796,0.010285201,0.060735226,-0.05666151,0.032698233,0.13391379,-2.3474504e-08,0.063250735,-0.08398461,0.026249325,-0.036891423,0.053023808,0.0037837073,0.00893388,0.0016028077,0.06225183,-0.023954697,-0.017319411,0.04801329,0.010792061,0.014846586,0.015730882,-0.0028252944,0.113737985,0.08075555,0.021489002,0.009117388,-0.095648766,-0.021203078,-0.051789615,0.027776863,0.0054435246,-0.15479338,0.017557677,0.08846281,0.06743552,0.013630558,0.0045052012,-0.0026877695,-0.024929278,-0.045287345,-0.011435433,0.08902441,-0.037629314,-0.05583993,0.053713188,0.015264093,-0.031394165,-0.06918321,-0.048889834,-0.028049983,0.02925563,-0.08197008,0.014272723,0.014417263,-0.031141186,-0.04925473,-0.035145663,-0.033597816,0.015679453,-0.0715758,-0.14711292,0.011344237,0.080962636,-0.09038312,-0.026061174,-0.14451946,0.051664233,0.047684122,0.09373138,-0.0075670457 +1.14.13.154,"The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B [1]. 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The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.",384,0.99999994,-0.040435564,-0.061735317,-0.10737088,0.037866212,0.11027901,0.048802394,-0.016243502,0.057222817,0.019031543,-0.039586168,-0.012302236,0.024598949,-0.12216316,0.07301166,-0.020826358,0.0026672601,-0.12513524,-0.011976588,-0.008461093,-0.05060505,0.060435053,-0.042219404,0.063676484,0.008563853,-0.051384374,0.016406247,0.1139089,-0.021184439,0.019843226,-0.04283007,0.047181394,-0.10723147,0.04184346,-0.048433006,0.011870993,0.10173192,-0.0027653475,-0.074416146,-0.00872755,0.039389063,0.024495604,-0.028182415,-0.016179278,0.009301502,0.03814901,0.0010626337,0.049707685,0.06504007,-0.0044034594,0.07511037,-0.03058343,-0.028235415,-0.06872081,-0.0067691887,0.0153792715,0.031233255,-0.039581306,-0.037016977,-0.044730105,-0.05517517,0.05914723,0.036870934,-0.042252198,0.0048098867,0.049644608,-0.025803536,0.053663466,-0.018958354,0.046105515,-0.043581154,9.305139e-06,-0.04090018,-0.009902944,0.004924892,-0.02340017,-0.056999553,-0.021744601,0.02785194,0.007597919,0.037317373,0.05579815,-0.043851618,0.017742814,0.06718078,0.016263569,0.05627577,-0.02811968,0.0017645989,0.049062636,0.004545846,-0.031919777,-0.036697805,-0.045570727,-0.007238883,-0.1295445,0.045643587,-0.004149933,-0.0040960894,-0.009167476,-0.021362588,-0.009276477,0.02848736,-0.046288844,0.010569907,-0.006085071,-0.042648338,-0.0006732654,0.04918557,-0.03480051,-0.022109466,-0.0011568491,0.061792497,0.07437422,0.016343577,-0.021985581,0.10895307,-0.07070456,-0.030231867,-0.11270448,0.076380245,0.0074522584,0.06261855,-0.034295805,0.10485941,-0.047547147,-0.0042396476,-0.10924946,1.7150396e-33,0.082609914,-0.053673092,0.0059505897,0.026941031,0.026447862,0.007822349,-0.069786504,-0.02830533,-0.05468125,-0.04586391,-0.032957494,-0.06771947,0.101198465,-0.0031854003,-0.051718954,-0.04458153,-0.04439524,-0.03219566,0.021291621,-0.011790234,0.06378644,0.036844593,-0.00613018,0.04035066,-0.003577412,0.085719764,-0.05768951,0.04103484,0.02861809,-0.013089083,0.018785927,-0.11087405,-0.044474967,0.009001819,0.06649227,-0.0048857974,-0.055822436,-0.07166716,-0.01823127,0.056318905,-0.04575589,-0.013391266,-0.058647007,0.009306142,0.04325404,-0.085112065,-0.032290824,0.12922479,0.12840168,0.07796313,0.07976174,-0.077093035,0.07653737,0.052991264,-0.039517242,0.044295777,-0.024400664,-0.06935702,-0.00898844,0.042838138,0.08591384,-0.010047511,-0.00011804834,0.0040795305,0.028803077,0.044122722,0.05253145,-0.05714846,0.112536296,0.04662116,-0.08260528,0.016736474,0.076382846,0.043608487,0.030296015,0.00011262941,-0.004192867,0.04253398,-0.03114826,0.010623558,-0.034854166,-0.041423477,0.032174926,0.019193254,-0.07007152,0.023173967,0.014105022,-0.0998012,-0.009626429,0.01730181,0.075638205,-0.09228136,-0.021069013,-0.07464215,0.06200962,-1.8014499e-33,0.10821281,-0.086971745,-0.034478717,-0.08728762,-0.042628974,0.02100632,0.042356186,-0.04267079,0.005612519,0.019238453,0.01604935,-0.010027223,-0.019860588,0.0020055766,0.03493759,0.008874248,0.029784635,0.043690942,0.07545661,-0.008530764,-0.016620869,0.05413897,0.027788581,0.05945277,0.025476197,0.007636367,0.04843331,-0.0016581564,0.021660836,0.0101666935,-0.044195786,-0.015376967,-0.079371646,-0.050452296,0.0432595,0.056537516,-0.06003888,0.040760856,-0.055229936,-0.026770119,0.03268649,0.021721337,0.006995581,0.006647507,-0.0051811263,0.089209326,-0.0730582,-0.015690036,-0.01715028,-0.06803758,0.054707084,-0.0061430177,0.0027857914,0.06030555,0.07172752,-0.004273388,-0.0073972866,0.018060632,0.017769197,0.014805514,-0.004456515,-0.073451534,0.0059633004,0.022475947,0.028352086,-0.010462145,-0.021646727,0.049693294,0.03311213,0.008111933,0.03868338,-0.011065718,0.10750786,0.08082212,-0.114970505,-0.0060529197,-0.07985985,0.0074703544,0.004729153,-0.028771438,0.018480113,0.04842302,0.0049951137,-0.08330777,-0.014609759,-0.052316237,-0.007845144,0.050839506,0.10996114,0.009195677,0.040232204,-0.05122996,-0.005826666,-0.016245058,0.06990891,-2.9356844e-08,-0.020009158,-0.048355877,-0.0070685777,-0.0026520896,0.005512787,0.07127797,0.03157179,-0.017471101,-0.04521332,-0.016738947,-0.012960991,0.028606843,0.03331847,-0.049959794,0.017187344,0.064363636,-0.024628384,0.03972113,-0.041181825,-0.04709969,-0.10564496,0.024147108,-0.116431765,0.028781781,0.06901829,0.008070813,-0.017849822,0.025287356,0.032961708,-0.045702994,0.09580418,-0.053680524,0.09259605,-0.023082633,-0.11199401,0.029077088,0.014626883,0.028281182,-0.0171377,0.008295778,-0.089755,-0.004545119,0.019172244,-0.013529913,-0.018528309,0.061648473,-0.05283109,-0.0042797746,0.00050686725,0.04519166,0.06362209,-0.033085354,-0.009923965,-0.049663443,-0.14641213,-0.021156378,-0.029986644,-0.07552677,-0.025184855,-0.0387851,-0.013803797,0.065959774,0.18778197,0.025575815 +1.17.2.2,The enzyme isolated from Pseudomonas putida contains heme c and requires pyrroloquinoline quinone (PQQ) for activity,384,1.0,-0.06454597,-0.03298147,-0.052125793,-0.046287023,0.01139967,0.12704925,-0.06555628,0.111628324,0.016871033,-0.0020753895,0.037138123,-0.087301865,-0.042298134,0.08272601,-0.0460349,0.08142266,-0.03367478,-0.0058106827,-0.021471156,-0.024530916,-0.039235115,0.0794734,-0.044497315,0.064521365,-0.016628265,0.0065743546,0.04164817,0.040794298,-0.040795576,0.029171472,-0.06803273,-0.04329766,0.037126344,-0.083784886,0.053290058,0.043935284,-0.04127671,-0.020615075,0.07579606,-0.0435439,0.062056743,-0.037762485,-0.049834013,-0.03427235,-0.004442798,0.045440223,0.11307712,0.039774593,0.035415616,-0.024728075,-0.05729505,-0.045952015,-0.031208675,0.027532855,0.017291458,0.06053043,0.042343818,0.019396184,-0.03942672,0.012860276,0.005328903,0.009519976,-0.00048110817,0.0323249,-0.03480608,-0.010884234,0.0066604964,0.035933714,0.01584973,-0.08611007,-0.020549923,-0.07351992,0.034680262,0.01952076,-0.01710678,0.044975344,-0.010463337,-0.030643957,0.049900424,-0.056370657,0.008990588,-0.06211041,-0.038007088,0.11690626,-0.0074205664,-0.026512062,0.028923657,0.029008845,0.05831842,-0.03443563,0.003326435,0.0139640635,-0.07125976,-0.14233658,-0.006077214,0.060269326,-0.013686876,0.07460583,0.016189972,-0.05073674,0.01787719,-0.013131684,-0.01089224,-0.070743345,-0.06288621,0.009127616,0.058119267,0.009611534,0.07969774,0.010311314,-0.026227172,0.022181937,0.015097644,-0.047752682,0.00757611,0.04458613,0.14426076,-0.03027376,-0.07729433,-0.013980717,-0.032746907,-0.054235652,0.08858821,0.029343205,0.012096904,-0.045757163,-0.03560611,3.5332087e-33,0.06279808,0.035983834,0.05044533,-0.04760399,0.04943764,0.032170497,-0.06878707,0.033560447,-0.03559274,-0.03736167,-0.032022707,-0.138188,-0.001909535,-0.0039235246,-0.019697241,0.03810745,-0.038452405,-0.050903056,0.037431605,-0.037472896,0.070768625,0.0010105136,-0.03914248,0.038778517,0.055766013,0.013918418,0.06888908,-0.043705568,0.002478966,-0.03310238,0.016243324,-0.026307866,-0.0960307,-0.10170978,-0.0026995717,-0.0025931192,-0.0885351,0.020298602,-0.06215173,0.040961046,0.053591777,0.056808904,0.01176216,-0.064758934,0.07567927,-0.10693998,-0.06796942,0.13511652,0.043636747,0.10297494,0.024443328,-0.07638594,0.0628131,0.048276007,-0.033971775,-0.042641062,-0.0005217239,0.057730105,0.076608375,0.007117027,0.10215838,0.06991044,-0.05288935,0.009328049,0.040980734,-0.015796462,-0.07138312,0.037566952,0.023144271,0.01711952,-0.018725038,-0.0057571307,-0.0424322,-0.020264572,-0.036817145,-0.11335852,-0.12522106,-0.0023872748,0.0537294,-0.031357203,0.0056016454,-0.1061624,0.048221793,0.019726263,-0.06728635,-0.006546878,0.028172387,0.056060627,-0.089364916,-0.019485345,0.10428165,-0.08319513,-0.02907684,0.046701115,0.013377747,-2.8019469e-33,0.030842673,-0.057250418,0.054180857,-0.030199733,0.02334414,0.017143793,-0.042299394,0.01704366,0.06215063,-0.031001866,0.054257035,-5.0861614e-05,0.033815682,-0.0038022425,0.019449279,0.014691872,-0.04185993,0.04632466,0.030142868,0.023002535,-0.020423846,-0.05203308,-0.031773698,0.05326565,0.095027834,0.039346576,-0.011237937,0.08815394,0.01623006,0.10826776,0.011286487,0.052112464,-0.078227125,-0.045954898,-0.0017950109,-0.029288514,-0.0084817875,0.026178189,0.059783876,0.026270853,0.021203084,0.013661896,0.0036585466,0.09104546,-0.07827494,0.10743217,-0.11229383,-0.009506538,-0.008059146,-0.027234677,0.02869012,-0.013874599,-0.042251695,-0.0068059675,0.03661754,0.008815587,-0.040635347,0.019780489,-0.07016677,-0.10535555,-0.032630496,-0.07243172,-0.055838995,0.0005136684,0.0050652684,0.0754471,-0.042588074,0.09234554,-0.02211835,-0.0590792,0.012608033,0.0335164,-0.0073717083,0.014147741,-0.10180501,-0.007869207,0.038294222,0.0024516326,0.12651798,0.04804575,0.04097182,-0.056384828,-0.041231908,-0.079869986,0.018274862,-0.04218413,-0.015864208,0.05578732,-0.053918414,0.008335302,-0.022887832,0.05112706,0.046716683,0.034829795,0.0502676,-2.7925719e-08,0.07031432,-0.107273184,0.034652606,0.04759136,-0.014619845,-0.0028540336,0.017260175,0.032504484,0.028241938,0.022097154,-0.008539426,-0.039745707,-0.035520468,0.009799473,0.056592155,0.0103909755,-0.038996287,0.00077476085,-0.034342844,-0.031447683,-0.05692585,-0.023115672,-0.09943082,0.003434457,0.023248542,-0.03281671,0.040904112,-0.0022056343,-0.0004994103,0.0023087761,-0.010035683,-0.039123103,0.022098657,-0.014640621,-0.023788597,0.051303577,-0.0062875873,0.016492749,-0.029134149,-0.04069995,0.037332658,-0.063322835,-0.06754259,-0.05627189,0.054267764,-0.013935855,-0.0050501125,0.03776143,-0.010232454,-0.052714717,0.0974068,-0.0022712213,0.074260145,-0.0067995125,-0.0880277,0.053079706,0.05266278,-0.022725353,-0.036822923,-0.03494195,-0.0013905044,0.0030174644,0.13996172,0.051542226 +2.1.1.243,The enzyme is involved in production of the rare amino acid (3R)-3-methyl-L-arginine. The compound is used by the epiphytic bacterium Pseudomonas syringae pv. syringae as an antibiotic against the related pathogenic species Pseudomonas savastanoi pv. glycinea. Other bacteria incorporate the compound into more complex compounds such as the peptidyl nucleoside antibiotic arginomycin.,384,1.0,-0.046736196,-0.075011894,-0.16527076,-0.10106867,0.030146785,0.046301596,-0.00348292,0.057649616,0.06869526,-0.0002918539,0.042882293,0.03461162,0.0032173274,0.060110424,-0.061919548,0.024840232,-0.101070635,-0.027392834,0.035703097,-0.043128937,0.0063623604,0.09681056,-0.027229564,0.0011631285,0.037607413,-0.019499762,0.05531409,-0.011814399,0.028944954,-0.005054893,0.04942695,-0.05504334,0.10449029,-0.08387192,0.07101087,0.07241207,-0.10632189,0.02776545,0.098670356,0.03716352,-0.0045273104,-0.03773363,-0.018160447,-0.066009626,-0.029681757,0.015895601,0.014014652,0.014431154,0.1225454,-0.00906478,-0.014379957,-0.013579292,-0.038070515,0.023982868,-0.008312942,0.018221518,-0.06617857,-0.054498415,-0.042023655,0.00648731,0.029737666,0.0038421631,0.014483884,-0.006466247,-0.06235398,-0.049015325,0.06335907,-0.08311323,0.069340594,-0.046848364,-0.048988014,-0.04099641,-0.06450151,0.06861506,-0.013175651,-0.037519086,0.009016814,-0.03233863,0.027613457,-0.058397945,0.05475037,-0.005724666,0.021434858,0.09807055,0.04322658,0.052140944,0.014947224,0.04665691,0.0984673,-0.02984541,0.07006613,-0.017368602,-0.033323918,-0.029535169,-0.020756088,0.0043346263,-0.049721256,-0.012035227,-0.008527207,0.022822399,0.051791787,0.01156759,-0.039480396,-0.104327776,0.01791771,0.03267182,0.035011858,0.03934105,0.0075491173,0.031548437,-0.07225625,0.009766819,-0.043521408,-0.058993004,-0.07174787,0.06641261,0.13721824,-0.036407985,-0.06387075,-0.0096429875,0.01815947,-0.005328008,0.040418763,0.047415495,0.0017391392,0.0063505117,-0.057562154,4.016831e-33,0.024755212,0.012612266,-0.04201705,-0.04038159,0.0135572655,0.07801591,-0.053027064,-0.0026603045,0.06480298,-0.05607165,-0.07717914,-0.066075526,0.0473943,0.056323092,-0.03560309,0.0141832465,-0.02837785,0.019942846,0.043826222,-0.019165033,-0.03905817,0.049815036,0.009288099,0.046948496,0.045588106,0.034784887,0.09244262,0.0052864794,0.067014776,-0.026396528,0.029162828,-0.06568924,-0.116953306,-0.03995331,0.03258244,-0.002878757,-0.042303674,-0.01821066,0.09321653,0.15152505,0.014049457,0.051054757,0.0436014,0.015394376,0.051417243,0.01263394,-0.05317286,0.14404936,-0.038814403,0.0047376724,0.06854221,-0.04049489,0.03748941,0.0058909245,-0.030178951,0.0035387208,-0.02271125,0.01887733,0.033513874,0.04523913,0.010155269,0.029500084,0.028604815,0.04776486,-0.025231238,0.009818147,-0.020356126,-0.0262302,0.02125638,0.015721943,-0.09321655,-0.018849744,0.025951518,0.02586662,-0.006918641,-0.09530018,-0.09266577,0.020035986,0.044432502,-0.026660342,-0.08964168,0.008392297,0.04662043,0.055809412,-0.10351917,-0.012781033,0.013647222,-0.0776571,-0.010990437,-0.07043865,0.054678988,-0.026060713,-0.12117919,0.07924353,-0.008081329,-3.902242e-33,0.08817639,-0.06025952,0.06415095,-0.039243855,-0.025948847,0.015754621,0.015167768,-0.023856169,0.022121986,-0.0061319307,0.05225212,-0.031023527,-0.0011737868,-0.029825903,0.07461263,-0.0052921083,0.011081194,0.016724396,-0.068990506,-0.01279689,-0.017241035,0.0055120783,0.01636647,-0.05671215,0.0014086454,-0.011450972,-0.05283648,-0.014638978,0.014765657,0.06667036,-0.012720829,-0.049003616,-0.042013567,-0.08537281,-0.047039207,0.066301584,0.0828889,-0.016015984,-0.05354854,-0.09059074,0.06410815,0.024227044,0.018694444,0.056662045,-0.045995872,0.076198384,-0.018573487,-0.005286075,-0.059916012,-0.10540273,0.0106873065,-0.082298495,0.07370472,0.030670514,0.008152062,0.005739615,-0.02815481,-0.022820298,-0.05707801,-0.0002485655,-0.013301206,-0.07236622,0.026194613,0.008663901,0.02991897,0.06570311,0.0035563703,0.033958428,0.030927664,-0.052055042,0.07284291,0.018961953,0.048298772,0.099193744,-0.038258288,0.036004696,-0.028774196,-0.08603831,0.01429913,-0.015202031,-0.0062221074,-0.07557085,-0.06591846,0.03904709,-0.0915729,-0.062243693,0.08856491,0.11196031,-0.022973208,0.0029721353,-0.013918516,0.056902066,-0.019446753,0.12190478,0.050380893,-3.721192e-08,0.05510123,-0.0504126,0.008743833,-0.04634036,-0.03054989,0.056082718,-0.029450968,0.035878018,-0.008619102,-0.018458989,-0.044815693,0.059765477,-0.01931053,0.012126486,-0.019740384,0.08082158,-0.05386168,0.047423296,-0.025743928,-0.013107566,-0.05781929,0.06080095,-0.08394382,-0.05831828,0.007940211,-0.010185812,0.041323513,0.048733424,-0.048012286,-0.027391229,-0.0015089526,0.022612626,0.014162243,-0.036577214,-0.05748683,0.050472308,-0.03024751,-0.04068919,0.034708936,-0.0060123233,-0.0025032703,0.019095834,-0.06873682,-0.03021014,0.014344238,-0.011962998,-0.06924996,0.0038831884,-0.036737066,-0.026093513,0.04419306,0.018254109,0.06518845,-0.021682708,-0.071671605,-0.019586958,-0.087124646,-0.11192577,0.03494314,-0.012271632,-0.03810967,-0.0027405343,0.14934267,0.056943063 +2.1.1.244,"This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. When the terminal amino acid is L-proline, the enzyme catalyses two successive methylations of its alpha-amino group. When the first amino acid is either L-alanine or L-serine, the enzyme catalyses three successive methylations. +The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids [1,2].",384,1.0,-0.03693232,-0.10225212,-0.094766155,-0.070221454,0.09922468,0.07698508,-0.038324084,0.08368502,0.025483208,-0.018617077,0.04801594,-0.008792416,-0.012447711,-0.0146849295,0.025258575,0.08180371,-0.137118,-0.06283972,-0.0053499914,-0.009913087,0.10250023,0.036725413,-0.046161905,-0.02717248,0.032804925,-0.021447401,0.053388648,0.017046383,0.053094946,-0.03430375,-0.0023059358,-0.05196992,0.008478315,-0.0108210705,0.043277763,0.039287228,-0.069661856,-0.013776277,0.02021241,0.05796077,0.08594307,-0.007690007,-0.01946467,-0.11895959,-0.009842219,-0.037918426,-0.03004277,0.023023523,0.00847676,0.004391977,-0.0444523,-0.10974329,-0.04056768,0.06259196,-0.09064725,-0.0011040035,-0.020838402,-0.0019663179,0.015585297,0.018362448,-0.00963924,0.045810353,-0.048580185,-0.044073477,0.11056971,-0.07628956,0.013226797,-0.06286943,0.040426325,-0.010791045,-0.04635684,-0.07101948,-0.027167113,0.047108095,0.022715101,-0.029598124,-0.0071377736,-0.015281093,0.02923385,-0.06644968,0.023693752,0.03363757,-0.0092229005,0.058244985,0.02820697,0.021766586,-0.052517906,0.062177952,0.112122476,-0.033508357,-0.04564643,-0.06671876,-0.03319381,0.0036799961,-0.10223487,0.035575274,-0.0032070347,0.017497899,-0.040218715,0.07367921,2.5868845e-05,0.035991497,-0.07051402,-0.077973604,-0.08287823,0.021672316,0.028421514,0.07498412,-0.03571416,-0.04892304,0.07028945,-0.03389061,0.09861798,0.034993507,-0.044135347,0.07599778,-0.024867423,-0.038756434,0.025502158,-0.038515147,0.023506347,-0.0020102384,0.11157101,0.031422336,-0.04977243,0.07790375,-0.06386319,1.5950514e-33,0.086160004,0.004909518,0.039501984,-0.055218518,0.014172993,-0.01772879,-0.08653319,0.018192654,-0.007418353,-0.05973327,-0.06348201,-0.08468558,0.018918613,-0.011624384,-0.027031573,-0.06646466,0.0401205,0.026910821,0.0033462108,0.04403909,-0.026155556,0.0028273575,0.005391591,-0.0069398633,0.0134604,0.015777394,0.03931693,-0.0015339557,0.022023378,0.038545992,-0.03462144,-0.035946127,-0.06995485,0.04505612,0.023139862,0.025403548,-0.031927083,-0.06602772,0.06572719,0.065456904,0.04708999,0.025579758,0.00151,0.040342595,0.021000998,-0.038348064,-0.058614362,0.07238306,-0.035382755,0.044350367,0.055308245,-0.04851094,0.051556353,-0.03791221,-0.11349772,0.011794963,-0.07496959,-0.026438225,0.029765906,0.103729725,0.01685319,-0.01464863,0.032748614,0.08263103,-0.017510943,-0.04059269,-0.05605355,-0.04165685,0.049394313,0.08271228,-0.07704578,-0.033029992,0.13559671,0.037644304,-0.008711125,-0.049450755,-0.07530364,0.035518385,0.031496838,0.02864006,0.030238025,0.060242835,-0.07554461,-0.0062623564,-0.04726345,-0.03670254,0.028934402,-0.10579346,-0.056508217,-0.016556544,-0.003238342,-0.038748104,0.006178531,0.057737626,-0.0032978477,-2.5811376e-33,0.03414451,-0.06163504,0.088359,-0.08853098,-0.0656671,-0.015364092,0.07355741,-0.07677792,-0.0036836423,0.003700246,0.09159671,0.0048986604,0.037486896,-0.03612512,0.055849407,0.027933268,1.923498e-05,0.06494069,0.014129836,-0.060595438,0.09537328,-0.002141293,-0.010950807,0.03144246,0.03351945,-0.03716255,0.034062102,0.09604088,0.058170006,0.06129387,0.02735765,-0.00079645694,-0.023930496,-0.05017425,-0.02896272,0.10449042,0.00799976,-0.015489937,0.043398216,-0.02984469,0.047075592,0.02043007,0.03483745,0.032849178,0.030722477,0.02343537,-0.029895572,-0.072991624,0.02182963,-0.08167917,0.034487817,-0.06087008,0.015436649,-0.03475768,-0.042491645,0.075979695,-0.038977247,0.040251043,-0.068443865,-0.019444855,-0.010591644,-0.025171775,-0.011960531,0.04604931,0.029556306,-0.007685373,0.01060346,-0.032046814,0.03973819,-0.030113883,0.0689924,0.0266013,0.01064605,0.06528585,-0.06307204,-0.06789534,-0.082394145,-0.04531157,-0.029323412,-0.10145288,-0.057086013,-0.07863137,0.0024913086,-0.06260952,-0.028130116,-0.023642024,0.046089932,0.14460997,0.012937595,0.05901885,-0.0713516,-0.0005906759,-0.025357785,0.018173156,0.05330051,-4.092221e-08,0.06013982,-0.1160171,0.03669428,0.043625027,-0.039958898,0.052296888,-0.026823623,-0.07993023,0.04106412,-0.040865257,-0.032299656,0.07150093,-0.044253442,0.0063215825,0.0074160025,0.085313074,0.021707397,0.09133265,-0.043501783,-0.0070022075,-0.020826794,0.037925623,-0.02760245,-0.004273325,-0.029237773,-0.01788023,-0.021622479,0.14084347,-0.021841092,-0.03755987,0.014561223,-0.0039337827,0.026285596,-0.029357359,-0.0070842705,0.018156853,-0.01803992,-0.03827346,-0.0084877815,0.03908205,0.07656807,-0.0068910625,-0.049320932,0.014220031,0.010605273,0.012092641,-0.00067139015,0.03434149,-0.041655943,0.041063353,0.03332623,-0.021111423,0.006760839,-0.042425524,-0.06054757,0.0036377588,-0.066056184,-0.04117191,-0.017212622,-0.026592346,0.03400577,0.07518758,0.17005686,-0.06498021 +2.1.1.245,"Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase, and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate.",384,0.99999994,-0.029389689,-0.021020133,-0.16904509,-0.021469584,0.096548155,0.040485457,-0.062172208,0.0061286036,0.01023461,-0.037869792,0.0049344776,-0.10930703,-0.10868189,-0.06773742,-0.07115683,8.042945e-05,-0.05874785,-0.03952447,0.04396111,-0.06040964,0.0118810395,0.00447624,-0.04145078,-0.03714323,0.01985936,0.059432134,0.036517177,-0.028058382,0.008838666,-0.02708136,0.041591726,-0.008026211,-0.003486179,-0.024224732,-0.007046711,0.11988769,0.020987492,-0.018145904,0.09005036,0.05452604,0.0077803144,0.01255904,-0.021507323,0.008622368,-0.010265077,-0.046318375,-0.02425454,0.034089852,0.014874675,-0.05388463,-0.02725622,-0.05042976,-0.050157703,0.026891563,-0.0030132027,0.018681841,0.004527561,-0.009666401,0.055581074,0.029320342,0.028393498,-0.037237294,0.019396786,0.0011893684,0.054379087,-0.06650787,0.06368202,-0.06763641,0.045499932,-0.009527301,-0.07403894,0.04646113,-0.026823506,-0.029811457,-0.041087512,-0.018690933,-0.045636363,-0.03607062,0.071180455,-0.027815463,0.008100146,0.09005256,0.0048630517,0.008963719,0.05689078,-0.009886287,-0.02600877,-0.0026135596,0.05758866,0.031921033,-0.010422922,0.0009105153,0.022102507,-0.0020015528,-0.074963555,0.027495636,0.12472535,0.021099042,0.028115781,-0.012680572,-0.029608084,0.12239318,-0.05957665,-0.054499,-0.07770402,-0.013227264,0.050995886,0.12996686,0.028941963,0.08133765,-0.019661704,0.023364095,0.063380055,-0.046809155,0.024628429,0.119758524,-0.01682148,-0.037823193,0.013995929,-0.024343733,0.064582616,-0.010125926,0.012044745,0.031513885,0.015566821,0.022037866,-0.071286425,2.843407e-33,0.11062121,0.09597591,0.02131632,0.07196353,0.020435847,-0.07497473,-0.09596513,0.02081762,0.033345018,0.028496264,-0.034917563,-0.046434764,0.05985405,0.00176181,-0.05735281,-0.03577471,-0.062013943,-0.052055676,0.021846391,0.021400651,-0.06604496,0.04986289,-0.0011493692,0.017354053,0.0121968435,0.052523006,-0.06298086,0.05187673,0.038813625,0.007132102,-0.022151416,-0.026534757,-0.13068019,0.025201729,0.056722637,-0.038100265,-0.035963424,-0.021306425,0.007963593,0.0448295,0.09355899,0.039711334,-0.00086481794,-0.061302308,0.050480604,-0.010932018,-0.015817259,0.062489502,0.014876019,0.0038565663,-0.011076256,0.0013563634,0.07035187,-0.040864922,-0.08868329,-0.019094344,-0.058917277,-0.033497382,0.04694709,0.08950094,-0.02189583,0.027301135,0.052569635,0.059913505,-0.07695012,-0.024594763,-0.049339917,-0.039777495,0.11029583,0.027586952,-0.02874065,-0.00065870734,0.07177057,0.024844142,0.006043386,-0.019375913,0.00127386,-0.04940077,0.05066415,0.027668267,0.05068924,0.012031631,0.004986992,-0.076481946,0.005148781,0.030635737,-0.07898514,-0.07095594,-0.023001317,0.03151796,-0.031695977,-0.0149424095,0.058351327,-0.035148136,0.034873843,-3.793893e-33,0.09337639,-0.09546374,0.00039337276,-0.15857504,-0.11548047,0.10078187,0.04398299,-0.08811575,0.0036251564,-0.022528645,0.08424662,0.017502666,0.0495748,-0.05431467,0.023656534,-0.00020790985,-0.003164887,0.09209428,0.02534127,-0.05010276,0.07668466,0.045147445,-0.032953333,-0.002124975,0.10444119,0.054382153,-0.055938352,0.035247024,0.0793055,0.049344666,0.033688165,-0.08143276,-0.037193604,0.023931805,-0.072033286,0.042207092,-0.03519381,0.029226743,-0.018083014,0.019154297,-0.013407804,0.011139742,0.033496324,0.057273265,0.05834977,-0.007888508,-0.07272846,-0.013933169,-0.009942204,-0.013191217,0.0610424,-0.050981473,-0.12823357,-0.038415868,0.019715814,0.10017311,0.046926785,-0.0135696,0.017090816,-0.044297326,-0.058502264,-0.0028303748,0.0033349895,-0.009933803,0.04697668,0.037410554,-0.030852567,0.05083957,0.091694,-0.007582861,-0.005574416,0.060704317,0.021639239,-0.016827658,0.0014680433,-0.071469925,-0.027954867,0.0016406879,-0.05871585,-0.04827347,-0.029223157,-0.016870908,0.040191047,-0.048880275,-0.099829525,-0.042351115,0.036183923,0.024326751,-0.046143424,0.038521692,-0.07220541,-0.046746515,-0.027328923,0.051777698,0.022382297,-3.9956774e-08,0.025941757,-0.04942285,0.061596252,-0.041082863,0.04637337,0.07339872,-0.015143818,-0.04781221,0.017493453,-0.04196357,-0.042213187,0.067110516,0.119041376,0.08984828,-0.031150024,0.016995152,-0.049186535,0.00788419,-0.03129486,-0.06805469,-0.042559564,-0.022588683,-0.05622694,0.08088117,-0.022824116,-0.07202846,0.016241191,0.097922474,0.0055795545,-0.02731225,-0.02767341,0.04250024,0.020370837,-0.013418777,-0.014891686,-0.022353096,0.008124195,-0.06399405,-0.023649823,-0.039834842,-0.0009059939,0.06452698,-0.08937407,0.042497404,0.037571847,0.0027952618,0.0028192925,0.054437246,-0.03886733,0.03562855,0.07115063,-0.0010652723,-0.0036240842,-0.018963024,-0.03650723,-0.02137426,-0.07989947,-0.062388424,0.044726174,-0.05703927,0.011875321,-0.0082583865,0.13778892,-0.07221296 +2.1.1.246,"The enzyme, which is involved in methanogenesis from methanol, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.90, methanol---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. Free methylcob(I)alamin can substitute for the corrinoid protein in vitro [5].",384,1.0,-0.06386088,0.0039085182,-0.13255678,0.012160799,0.049132336,0.043998256,-0.07561963,-0.0079561025,-0.015371292,-0.051550824,0.020231433,-0.099272996,-0.06790035,-0.037524,-0.00017686687,0.079659484,-0.05715076,-0.008319384,0.00015815118,-0.07166683,0.04952142,0.020469816,-0.060163915,-0.033073675,-0.02833207,0.014376266,0.029660925,0.025663098,0.04828781,-0.013181564,0.011420866,0.012646323,0.019518154,-0.024179306,0.023815831,0.094314136,0.04873059,-0.08877547,0.038104583,0.007979863,0.041738737,0.06280725,0.04512299,0.008530127,0.0020671918,-0.054804992,0.00075815874,0.009270023,0.018459374,-0.11459554,-0.065348595,-0.06407694,-0.025687363,0.05452385,0.09131684,0.070094645,-0.092069335,-0.036696292,0.02319838,0.0048932983,0.027326096,0.0046330597,0.04546699,-0.017327193,0.068444654,-0.012489911,0.010709639,-0.07508724,0.09429485,-0.048935086,-0.06979144,-0.026146725,-0.05214615,-0.036858335,-0.05558352,-0.007021029,0.000997236,-0.048551515,0.06799056,-0.03972653,-0.031671286,0.093175605,0.058853086,-0.049756907,0.030606441,0.005612585,-0.04174894,-0.0031472342,-0.0031500182,0.03726175,0.037089277,-0.042947777,-0.03180499,0.005202419,-0.058814347,0.02181691,0.13871695,0.063177615,0.038038548,0.011922023,0.006001599,0.09222411,-0.10687026,-0.015410904,-0.06668349,-0.034381296,0.11199935,0.09831648,-0.032384977,0.093117595,0.02501768,0.025566857,0.028198663,-0.0020903724,-0.004339012,0.07469697,0.0123872,-0.021689158,0.014424158,-0.0008367093,0.052212287,0.021669593,0.02468002,0.010345141,-0.038828745,-0.003472245,-0.07307342,1.9648803e-33,0.086357065,0.07133704,-0.008043903,0.01898993,-0.04279618,-0.06485153,-0.096752815,0.046984017,0.03270904,-0.04213503,-0.0866531,-0.026175195,0.025603572,-0.00075208646,-0.07381717,-0.057784405,-0.081720315,-0.06907802,0.052022524,0.025100302,-0.040432993,0.030763477,-0.046978526,-0.015099306,-0.03299143,0.015455,-0.058771797,0.010237495,0.058266338,0.024166996,-0.033640858,-0.02729891,-0.08597659,0.028013444,-0.02751253,0.010479245,-0.06958029,-0.017849473,-0.031675015,0.05210928,0.05488657,-0.0038958008,-0.029342681,-0.0068963966,0.036233358,-0.023806637,-0.07141766,0.04942721,0.066445634,-0.03422507,-0.041144293,-0.007845748,0.037925124,-0.08502128,-0.0872304,-0.025650112,0.021535067,-0.0807014,0.007024647,0.09347959,-0.06461602,0.00056209875,0.00076470326,0.09782586,-0.038993027,-0.02394858,-0.07601443,-0.08119595,0.015774498,0.028811542,-0.018995766,0.0061704526,0.011894613,0.055992734,0.014960715,-0.036070224,0.04840473,-0.0008376846,0.041720137,0.023323689,0.07387923,0.032359976,0.03420113,-0.06173058,0.027449297,0.0026290915,-0.06693072,-0.060080722,0.014069464,0.015927505,-0.01931217,-0.017291218,0.0036913094,0.0022540763,0.017502487,-4.2669468e-33,0.08116697,-0.08336294,0.032036018,-0.13239254,-0.08728405,0.1049299,0.047863573,-0.081718326,0.047744125,-0.035371296,0.10124625,-0.008282891,0.06388088,-0.026784305,0.037505873,-0.0005994699,-0.054865032,0.10568552,-0.0009097665,0.0106164925,0.03488902,0.08173322,-0.016153479,-0.059300866,0.0355322,-0.009052872,-0.02431262,0.021117277,0.049086444,0.09411018,-0.0027525786,-0.08496529,-0.08730286,-0.013001123,-0.058295276,0.05293154,-0.063353024,0.0038142202,-0.019816937,-0.010165372,-0.019914111,0.03657647,-0.015197153,0.046490174,0.052368686,0.07752126,-0.08373926,-0.012458012,-0.0053752693,0.009719099,0.033674568,-0.027021077,-0.07870139,-0.04852876,-0.0075617237,0.09260755,0.07476204,-0.028929925,0.07003366,-0.044225436,-0.066556156,-0.01736836,0.0109659815,-0.043254804,0.06508507,0.058674537,0.03336197,0.021080129,0.06261338,-0.006430056,0.06165335,0.071846955,0.017737266,-0.010551334,-0.037629835,-0.0612378,-0.10290678,0.03538629,-0.056058884,-0.031746387,0.00088161184,0.017038325,0.07102477,-0.06294123,-0.007817961,-0.01293272,0.095700726,0.06481354,-0.019843152,0.03185454,-0.08484357,-0.027144121,-0.07336252,0.022192333,-4.2816123e-06,-4.4917993e-08,-0.016200813,-0.077717714,0.040486008,-0.03613176,0.020921445,0.12960784,-0.035309028,-0.062361006,0.057144873,0.018270912,-0.025596779,0.07754721,0.05175853,0.062016543,-0.08810129,0.028330622,-0.043195464,0.00088203396,0.016681803,-0.037175596,-0.028360628,-0.0016657497,0.004189455,0.047779117,0.021686483,-0.06614607,0.03291478,0.14664608,-0.020048074,-0.08640948,-0.024127357,0.040903762,0.015000767,0.03016374,-0.07897914,0.004427845,0.007701542,-0.010026507,-0.05323617,0.008087553,0.02364537,0.004660451,-0.03747334,0.030648729,0.068057746,-0.033118874,-0.027442122,0.0786668,-0.0047039655,0.0375484,0.064788125,-0.04240437,0.01219297,-0.04056761,-0.04633166,-0.031145925,-0.02453406,-0.041717947,0.014274027,-0.008804504,0.0342019,0.012089926,0.11685414,-0.075003445 +2.1.1.247,"Contains zinc [2]. The enzyme, which is involved in methanogenesis from mono-, di-, and trimethylamine, catalyses the transfer of a methyl group bound to the cobalt cofactor of several corrinoid proteins (mono-, di-, and trimethylamine-specific corrinoid proteins, cf. EC 2.1.1.248, methylamine---corrinoid protein Co-methyltransferase, EC 2.1.1.249, dimethylamine---corrinoid protein Co-methyltransferase, and EC 2.1.1.250, trimethylamine---corrinoid protein Co-methyltransferase) to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis.",384,0.99999994,-0.03185587,-0.0005297178,-0.12564048,0.008100203,0.11083856,0.018340267,-0.0695966,0.02768934,-0.013834398,-0.0340297,0.002859723,-0.09430298,-0.049242925,-0.0055847843,-0.002724976,0.058116954,-0.072587796,-0.019713705,-0.009790105,-0.024079675,0.052550577,-0.005592312,-0.060260337,-0.03663556,-0.017262274,0.03935365,0.035837,0.014644151,0.040372536,-0.009856658,0.023039602,-0.020976612,0.03874805,-0.017129,0.018548073,0.0747567,0.02333302,-0.078932054,0.032454696,0.010393808,0.03278143,0.100459844,0.03125109,-0.04284388,-0.0029023744,-0.03519154,0.006182869,0.025678152,-0.02307805,-0.07108372,-0.051287614,-0.027878586,-0.0050362092,0.046975322,0.027334021,0.08853131,-0.095701225,-0.015317772,0.028721485,-0.0012540203,-0.007481294,-0.057067696,0.01840302,-0.04216577,0.062195085,0.0077580204,0.05269444,-0.07649031,0.046001706,-0.042537067,-0.07214684,0.0077400003,-0.045624044,-0.020129712,-0.034323104,0.05036465,0.026218453,-0.057484485,0.061951693,-0.026743986,-0.027777437,0.08042386,0.062441595,0.0049472186,0.040282387,0.025867414,-0.05379034,0.043123268,-0.026995786,0.03598777,0.011911568,-0.04812774,0.014989279,0.06752254,-0.0952029,0.038160406,0.123599365,0.09230949,0.07420525,0.026098687,-0.018358782,0.06423834,-0.04163002,-0.043407153,-0.06722282,-0.014428064,0.10440811,0.15156218,-0.009504662,0.06918518,-0.012979197,0.014722904,0.036231287,0.007971399,-0.0007762979,0.089164,0.032246448,-0.026244784,0.006017073,0.007863271,0.06436971,0.017930277,-0.0016781446,-0.024388827,0.0018041164,0.049855594,-0.07866283,1.52809325e-33,0.07035899,0.09799885,0.016598653,0.022983583,-0.041340064,0.03030908,-0.09177827,0.07647524,0.032010112,-0.060119525,-0.0640666,0.00045837075,0.06352758,-0.015512798,-0.085561894,-0.1127591,-0.007914608,-0.03579008,0.03204098,0.022427725,-0.006207888,0.064624704,-0.056471232,-0.000954827,0.035898536,-0.012995948,-0.04108179,0.0057130028,0.04330827,0.007229394,-0.06085865,-0.05316165,-0.075790055,-0.022567209,0.08467259,-0.018103415,-0.040254477,0.0026130467,-0.036978513,-0.017395727,0.08103371,0.0075111142,-0.096200846,8.621524e-05,0.019861592,-0.10158262,-0.064134166,0.037318245,0.051452067,-0.035101917,-0.03311224,0.027945349,0.06843,-0.07291757,-0.119865626,-0.055838596,-0.030197883,-0.08601315,0.03165335,0.06319901,-0.042379234,0.023298556,-0.017106662,0.04848111,0.007208399,-0.039319154,-0.067051046,-0.049067933,0.01821068,0.027522145,-0.04979413,-0.034981247,0.046909984,0.03920894,0.04508733,-0.079235025,0.013153873,0.02432025,0.074517995,-0.013224079,0.028433362,0.036261804,0.0508497,-0.0646693,0.0034157697,-0.027681477,-0.061611973,-0.07155517,-0.003507861,-0.013143268,-0.037094053,-0.05294787,-0.010329311,-0.002728574,0.0034215332,-3.3130037e-33,0.042836614,-0.05330398,0.013466659,-0.10310349,-0.051493473,0.09902906,0.0516688,-0.0860652,0.021253975,-0.095024094,0.14788078,0.006456405,0.053232465,-0.015975593,0.053287636,0.022518246,-0.035353605,0.13220114,0.05493107,-0.020787667,0.0393272,0.07117818,-0.04453299,-0.0061728307,0.029579246,0.024833214,-0.019256998,0.00061822543,0.085983954,0.12956814,-0.018190848,-0.004636706,-0.042215496,-0.02746705,-0.058098618,0.008648695,-0.049536973,-0.0171242,-0.033351276,-0.022004925,-0.018632112,-0.042398095,-0.018793061,0.052676953,0.070031635,0.07759003,-0.066276975,0.009898016,-0.030671863,0.059967496,0.012979567,0.021665864,-0.119569205,0.0055103754,0.038049255,0.03310732,0.048736308,-0.0020564536,0.06157063,-0.049629476,-0.071384616,0.012923225,-0.0066557745,-0.0120885745,0.0765745,0.021151863,0.011347163,0.03267141,0.056348704,-0.014575238,0.023593275,0.13368176,0.037144132,-0.04238327,-0.030692954,-0.030660404,-0.09757831,-0.005611866,-0.05741944,-0.012942994,0.014476583,-0.008954578,0.091372,-0.025196359,-0.030386098,-0.024283843,0.037365954,0.041862138,-0.086060144,0.02772162,-0.08716356,-0.087508574,-0.06463239,0.043129276,-0.008797519,-4.907039e-08,-0.001464456,-0.030210776,-0.0055521866,-0.06211641,0.0039578495,0.1167358,-0.006970468,-0.07495664,0.02697373,-0.0057502147,0.046780366,0.03838793,0.0476345,0.019649906,-0.062030263,0.0016386311,-0.051414426,0.014516045,0.0009651382,0.051465336,-0.015041707,-0.02830441,-0.0050058756,0.046679482,0.068538874,-0.11254921,0.00027089662,0.10182459,-0.009548423,-0.0784058,-0.022626212,0.0075143175,0.074596435,0.0018100339,-0.04870961,-0.013799472,0.009087898,-0.023119692,-0.05241007,0.032324173,0.0056764996,0.0057509425,-0.050111823,0.03805495,0.07488751,-0.05350403,-0.007921092,0.08857896,-0.03079104,-0.007122864,-0.003849382,-0.05439327,0.00035437898,-0.058572512,-0.034060474,-0.011227609,-0.04095891,-0.03614289,0.013072565,-0.03904507,-0.007533534,0.0068882597,0.13623406,-0.05585598 +2.1.1.248,"The enzyme, which catalyses the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.",384,1.0,-0.011746147,-0.018128501,-0.13981467,-0.0317793,0.11821921,0.024102947,-0.06340284,0.0017198444,-0.011442363,-0.034946352,0.02781521,-0.06928152,-0.025066657,-0.015349204,0.00023887887,0.06061071,-0.04627532,-0.033700794,0.051617883,-0.022977132,0.07064561,-0.015483008,-0.07298235,-0.043796346,-0.042409305,0.07672825,0.061585233,0.05036903,0.042388633,0.0074105146,-0.0010423207,0.035611227,0.00040440893,-0.012609785,0.012357522,0.1279268,-0.015471345,-0.11251103,0.048573088,0.04080011,0.055046517,0.06338729,0.097906806,-0.058589835,0.0013010239,-0.03885524,0.020993894,0.02578723,-0.018846003,-0.061272692,-0.014708921,-0.07331297,-0.02253775,0.04548015,-0.016445428,0.08382269,-0.08733703,-0.033271495,0.02071099,-0.026933616,0.0014197573,0.0089764185,0.016275847,-0.014328802,0.11800074,-0.012047155,0.027590906,-0.09929066,0.06558323,-0.087268524,-0.041998163,-0.0351728,-0.04216996,-0.04289413,-0.022241427,0.027863061,-0.018255562,-0.061166037,0.055443443,-0.054205466,-0.054444466,0.071111694,0.03287978,-0.034329213,0.036495727,0.025477499,-0.01860687,0.036870018,-0.009398611,0.022936182,0.032890007,-0.03172915,-0.010553527,0.017287662,-0.10834897,0.006074951,0.09054201,0.06490941,0.014369276,-0.0065047485,-0.013318815,0.11301721,-0.08850115,0.0012947826,-0.05607667,-0.03799505,0.118300706,0.1577444,-0.043669958,0.04991003,-0.057770003,0.07327815,0.035975926,-0.016235944,0.032346036,0.09814108,0.059079554,-0.013996028,-0.038445447,0.02396578,0.043609656,-0.010256282,0.01498907,-0.03072967,0.013860638,0.009768781,-0.069353834,3.770905e-33,0.0704516,0.07315847,0.013104455,-0.011190529,-0.023526933,0.006400605,-0.064134955,-0.0008715577,0.04296546,-0.06098969,-0.073785394,0.002966378,0.05806574,0.030491907,-0.079239085,-0.054462437,-0.048391014,-0.031428624,0.069195926,-0.016242389,-0.0077499636,0.10460212,0.0027856505,-0.0062216287,-0.017815314,0.017600508,-0.035592336,0.0075613772,0.053941898,0.011914632,-0.053790905,-0.037031,-0.10820429,-0.008089026,0.02410713,0.010459654,-0.07483134,-0.023756605,-0.011566225,0.049653262,0.05090813,-0.037623182,-0.040606033,0.007992579,-0.031474322,-0.07306489,-0.06035552,0.022801252,0.023775999,-0.03167151,0.021275073,0.010412126,0.049838435,-0.07098955,-0.11479784,-0.0405867,-0.02575631,-0.09982808,-0.019157488,0.04943369,0.029209381,0.003368552,0.031582408,0.0705258,0.012555012,-0.046415415,-0.038362663,-0.0964742,0.10016123,0.021060277,-0.025751274,-0.05902711,0.06585994,0.07779074,0.038017426,-0.040028542,-0.029277595,-0.017292483,0.060523484,-0.0018213653,0.03605448,0.018418796,0.048390504,-0.06312317,-0.004307881,0.016635392,-0.015824014,-0.08228593,0.011844003,-0.0030155517,-0.01689721,-0.058062907,0.01988661,-0.017786365,0.017008692,-4.660569e-33,0.048097532,-0.07388592,0.04942562,-0.11102367,-0.06271383,0.061048474,0.06197791,-0.07828904,0.0059578107,-0.048909612,0.13245031,-0.002140508,-0.011509083,-0.0330875,0.050687473,0.0015230788,-0.047653288,0.10536215,0.022446921,-0.023426676,0.036043864,0.024581468,-0.018609544,0.008123484,0.023530865,0.049835242,-0.04699507,-0.007887715,0.07131993,0.07016518,-0.024000077,0.009101488,-0.033029426,0.008242209,-0.012441189,0.055697016,-0.054444134,0.017807882,-0.0014332249,-0.030751355,0.002183765,-0.011866019,-0.0122244265,0.03782877,0.060839135,0.005623498,-0.073642865,-0.03801915,0.0018564312,0.048021507,0.009461119,-0.0019394003,-0.06760458,-0.040414505,0.046727538,0.06779471,0.008037967,-0.00217416,0.05200101,-0.05837198,-0.057701707,0.01817938,-0.045974445,-0.0045946287,0.09948457,0.048290018,0.016293278,0.006332092,0.0742427,0.009863181,0.04690338,0.0974254,0.05500165,-0.020376142,-0.024135087,-0.079548955,-0.07730484,0.024780396,-0.04082086,-0.061225913,-0.0023759243,-0.03055273,0.0693046,-0.018730478,-0.0479807,-0.025819093,0.0879555,0.011685796,-0.03865576,-0.007076721,-0.040531084,-0.081733674,-0.06835382,0.014733487,0.036534768,-4.219038e-08,0.012413059,-0.047631122,0.0129099,-0.036060978,0.010030529,0.1323422,-0.05400812,-0.104346134,0.06664854,0.04561837,0.025748678,0.001874672,0.055714797,0.028352205,-0.083039045,0.024858117,-0.06325492,0.04126567,-0.00089359406,-0.028530993,-0.06919551,0.0052404488,-0.017183889,0.047115643,0.06649644,-0.02120794,-0.014824037,0.1604013,-0.025343435,-0.025070602,-0.0004899251,0.0059741465,0.04105417,0.029145505,-0.040087145,0.020003641,0.02104192,-0.0104610445,-0.059445024,-0.013700777,0.022453219,-0.0038484198,-0.050453953,0.030394202,0.09333929,-0.030079575,-0.030115632,0.07495669,-0.03441013,0.03898311,0.025832715,-0.046462286,0.01182826,-0.053793617,-0.04587141,-0.035824087,-0.060755845,-0.06834124,-0.008838897,-0.050785586,0.0058720433,0.026251081,0.14186452,-0.08444854 +2.1.1.249,"The enzyme, which catalyses the transfer of a methyl group from dimethylamine to a dimethylamine-specific corrinoid protein (MtbC), is involved in methanogenesis from dimethylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.",384,1.0,-0.023328267,-0.019342631,-0.15388405,-0.018317437,0.08408785,0.04185095,-0.06600464,0.01688083,-0.018330013,-0.052594405,-0.0022303478,-0.07424919,-0.07399067,-0.025713082,-0.0063644373,0.052554604,-0.050234426,-0.038891744,0.007186193,-0.020887658,0.047875237,-0.018204946,-0.06549529,-0.032466035,-0.03385391,0.05521662,0.050101504,0.02534114,0.052896798,-0.0016359868,0.023591792,0.038905885,0.010316778,-0.016607754,0.033528395,0.08681037,-0.017176429,-0.09554175,0.028299846,0.033981863,0.054980338,0.051213562,0.0655156,0.014214136,-0.017763602,-0.03966567,0.02774533,0.050858874,-0.032012094,-0.044920407,-0.036244486,-0.08660404,-0.050125636,0.037138954,0.0020131639,0.09872192,-0.06747824,-0.029756779,0.03904154,-0.0157994,0.010163764,-0.0028057187,0.032794826,-0.016566688,0.1023179,0.008773299,0.030572895,-0.10798826,0.06068168,-0.10903025,-0.036381032,-0.03621582,-0.06637646,-0.02886117,-0.021557879,0.039474767,-0.020039642,-0.067069374,0.05785922,-0.047960676,-0.044630453,0.06930643,0.049862493,-0.022684548,0.043082867,0.0030696965,-0.021106193,0.041445244,0.0056920126,0.006646973,0.04208341,-0.026104264,-0.007466588,0.04454648,-0.114855014,0.02291308,0.08403276,0.061928872,0.01840545,0.007820926,9.751448e-05,0.10323488,-0.09161194,0.010831493,-0.051070277,0.0013990721,0.105131,0.15006252,-0.04340999,0.056415156,-0.0077402364,0.06520383,0.04019934,0.014143779,0.026061198,0.044905186,0.053097043,-0.024606058,-0.030788539,0.0009693708,0.06445435,-0.001886765,0.01574113,-0.041732237,-0.023308521,0.02792698,-0.06261098,4.541099e-33,0.081145674,0.07150966,0.0027478556,-0.023858134,-0.028706297,0.00257124,-0.051812552,0.0006396694,0.043393943,-0.023904186,-0.06299286,-0.0145804575,0.06263261,0.03323818,-0.10643055,-0.04035361,-0.049136996,-0.019076861,0.04524992,-0.0067957616,0.000891104,0.119791314,-0.0017808985,0.003238455,0.006404562,0.001666197,-0.06246522,0.035026703,0.05954501,0.013070437,-0.03501431,-0.044923093,-0.12938146,-0.013821566,0.05043197,-0.00409773,-0.06499334,-0.013805478,-0.023796583,0.07330738,0.026491398,-0.037202794,-0.05231849,0.0256717,0.0017927822,-0.0578111,-0.042985637,0.054415286,0.006924386,-0.053207222,-0.007882698,0.015826158,0.05178373,-0.06078619,-0.088024676,-0.021505462,-0.02323342,-0.0836103,0.011258414,0.05428297,2.6240596e-05,0.030798728,0.032862015,0.053502925,-0.0039813374,-0.06347718,-0.048179686,-0.08417395,0.06619651,-0.0036166925,0.0022271313,-0.031074842,0.08189653,0.06501,0.036281046,-0.057387307,0.0005281699,-0.020602008,0.039367672,-0.029709699,0.066841856,0.021197777,0.10506901,-0.07832279,0.015786437,-0.009057482,-0.041437227,-0.09552044,-0.032078154,-0.0023180363,-0.015804809,0.0008411327,0.02442981,-0.023642005,0.015318551,-4.9333422e-33,0.06481213,-0.075085126,0.054515038,-0.09756339,-0.06875198,0.06513497,0.058908597,-0.06916218,0.015004939,-0.06266039,0.14275151,-0.008696564,-0.014949713,-0.052630313,0.07975564,0.0052059437,-0.05991138,0.13947722,0.015857134,-0.020831184,0.02684609,0.03013666,-0.053577796,0.030988017,0.02683587,0.02995979,-0.050881196,-0.024750099,0.065420955,0.07561471,-0.018623658,-0.0025740922,-0.021848513,-0.030436594,-0.036914345,0.0476429,-0.028755149,0.009425356,-0.007329846,-0.0042536063,-0.03204219,-0.013487167,0.0040157023,0.02615636,0.04526673,0.027531758,-0.06834534,-0.045078214,0.0031812862,0.040898588,0.0329691,-0.025347894,-0.06294006,-0.010827731,0.06947803,0.06982408,0.0374427,-0.0014170472,0.06781206,-0.058684345,-0.03322095,-0.017988967,0.004460434,-0.03764229,0.10223099,0.057301346,0.006142512,0.03642642,0.064939,0.017865947,0.047913384,0.11012606,0.031126311,-0.03840866,-0.03411136,-0.056760624,-0.07923401,0.016812677,-0.038405746,-0.04843367,0.012004919,-0.022398679,0.07966709,-0.021390652,-0.037946682,-0.042613037,0.11321987,0.009449309,-0.045914423,0.009675084,-0.07191587,-0.08878782,-0.067208275,0.02398008,0.06844947,-4.2391108e-08,0.016558703,-0.037057873,-0.022694893,-0.04415821,0.0134048,0.09745164,-0.03402732,-0.10263763,0.055581693,0.05306801,0.011189913,0.0053131366,0.06283389,0.03738885,-0.06816268,0.003782081,-0.07073989,0.015181698,-0.007896991,-0.0068406034,-0.038561728,0.032225773,-0.007772918,0.038076717,0.07406528,-0.055123888,0.006504979,0.1579853,-0.012242821,-0.029777756,-0.014855318,0.0010187841,0.04140369,0.006515623,-0.04892704,0.01078283,0.028676542,-0.020415714,-0.04413706,-0.041237846,-0.0066317474,-0.0136721525,-0.053451646,0.02564871,0.094610624,-0.042577464,-0.018940005,0.10174521,-0.070710555,0.030073294,0.025100596,-0.031545315,-0.0041065095,-0.03504825,-0.042354632,-0.016544921,-0.07174628,-0.04242197,-0.02027335,-0.056872357,-0.006226118,0.0093658,0.13895461,-0.11991119 +2.1.1.250,"The enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine. The enzyme contains the unusual amino acid pyrrolysine [2]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.",384,1.0,-0.013212491,-0.005036395,-0.12911071,-0.020828709,0.112788945,0.004354711,-0.063078225,0.025029434,-0.03009188,-0.052642833,0.02399883,-0.07610163,-0.042695567,-0.023587422,-0.008601235,0.052899163,-0.057249654,-0.01770755,0.039525595,-0.02626701,0.0609445,0.010013478,-0.08366422,-0.022936227,-0.014891199,0.046392262,0.08023859,0.028328018,0.03903344,-0.0014702387,0.026018687,0.016013619,0.036564335,-0.015329014,0.007284239,0.12203907,-0.0128682135,-0.108789876,0.048273653,0.032946885,0.036353048,0.041555904,0.071645334,-0.044917013,-0.022476468,-0.0556689,0.029189209,0.03732274,-0.054583624,-0.039842915,-0.012341025,-0.051702045,-0.047246788,0.034758218,-0.011339212,0.070775606,-0.0845567,-0.024661683,0.023178969,-0.012981917,0.0045883656,-0.013987339,0.011902821,-0.0372598,0.115966104,-0.012528303,0.049252294,-0.092333876,0.071740516,-0.10861924,-0.012533423,-0.01615182,-0.06127623,-0.057093397,-0.02265536,0.02936819,-0.016236715,-0.07779446,0.04358934,-0.04889869,-0.05600969,0.055020664,0.043564826,-0.012391482,0.03331724,0.02575777,-0.035156906,0.048813883,-0.014595915,0.023331922,0.05117335,-0.011281991,-0.01624002,0.054477442,-0.10200279,0.01753419,0.11160245,0.058556084,0.009520611,0.022771215,-0.022260344,0.08452393,-0.10513241,0.024254754,-0.058986273,-0.015651338,0.10268607,0.1275124,-0.038381934,0.04758407,-0.04963458,0.070732884,0.022401933,0.010992443,0.018526454,0.069866516,0.049574148,-0.037650026,-0.018706197,0.013195348,0.046946596,0.012717474,-0.009026963,-0.020158721,0.017387152,0.030257218,-0.042964034,4.2055834e-33,0.059848055,0.08644328,-0.0074887956,-0.004978961,-0.04418719,0.01796723,-0.08036888,0.014444674,0.031963203,-0.08102234,-0.06972134,-0.017892208,0.057757165,0.019408995,-0.081892066,-0.07691657,-0.036764674,0.0013444088,0.0603507,-0.007294879,-0.020859333,0.107050106,-0.034734923,0.01968057,-0.002786866,0.012517254,-0.045869917,0.008797146,0.0716657,0.020900592,-0.054159764,-0.039649986,-0.08890285,-0.0122350985,0.041257318,0.04417027,-0.05886548,-0.009415539,-0.03619675,0.041393586,0.04976004,-0.003069504,-0.05868568,0.005308099,-0.02638715,-0.10582057,-0.05828339,0.053293187,0.013626233,-0.0052690916,-0.018279064,0.016431523,0.06824737,-0.072766334,-0.106715135,-0.058557235,-0.028508374,-0.11622582,0.0095590595,0.04548898,0.02845806,0.029247006,0.036925256,0.050734706,0.016906416,-0.04550201,-0.043392945,-0.07073902,0.11148525,0.03526979,-0.05418612,-0.018769214,0.051272124,0.07600227,0.032449476,-0.057244487,-0.016207604,-0.0077798553,0.0635208,-0.01978325,0.06446452,0.033315104,0.088584065,-0.09720563,0.009470304,-0.0090413615,-0.045287807,-0.079226576,-0.018852469,0.00181402,-0.008304711,-0.04460122,0.0010120935,0.014214154,0.026060415,-4.7107525e-33,0.05200864,-0.07933078,0.05939902,-0.07363624,-0.071231134,0.07551088,0.0451013,-0.06347927,-0.023216093,-0.06195453,0.14479156,0.002601681,-0.0092868665,-0.034035895,0.07087573,0.008059262,-0.020886872,0.10478353,0.029663907,-0.03198293,0.029184736,0.03552109,-0.06203582,0.005976993,0.018225607,0.04116732,-0.06327329,-0.03523906,0.08490783,0.06954017,-0.0202325,-0.011618896,-0.033663202,-0.0042846776,-0.021688618,0.06752181,-0.034866896,0.053887907,-0.01867403,-0.029190715,-0.0050509307,-0.019161707,-0.008941698,0.052662723,0.04076493,0.023074407,-0.051115617,-0.00071905606,-0.013467172,0.047472615,0.035223126,0.002411325,-0.06818649,-0.015538389,0.058249716,0.055258468,0.034329373,0.00025934773,0.021937566,-0.06705441,-0.054285735,0.013200582,-0.02104945,-0.02367789,0.07875838,0.032026533,0.013779405,0.022551658,0.066601835,-0.0109035615,0.04373391,0.13045216,0.070829935,-0.05030894,-0.027654566,-0.079918094,-0.07197416,0.01834949,-0.040066604,-0.052201588,0.00030801317,-0.030849637,0.09641594,-0.05002892,-0.040656295,-0.043851163,0.06393401,0.046142783,-0.05471209,0.002164822,-0.06447974,-0.08646464,-0.07149806,0.0050026523,0.03383189,-4.2086988e-08,0.008111458,-0.035683215,-0.012204569,-0.039738372,0.0018069829,0.1351026,-0.029621948,-0.10164055,0.058663044,0.02558525,0.016083669,0.012426437,0.043634705,0.020178484,-0.068347916,0.006599124,-0.05689516,0.03020122,-0.010864213,0.009085052,-0.06892389,0.0005031519,-0.013104889,0.02809801,0.065555006,-0.042034462,-0.013490154,0.15852079,0.0056840614,-0.029503094,-0.01116118,0.005642926,0.040465035,-0.0070731263,-0.03913775,0.029920537,0.046228167,0.0061427304,-0.04757123,-0.01603631,0.033995595,-0.029234251,-0.054342795,0.031241667,0.09254462,-0.038027357,-0.02306686,0.08512415,-0.04170151,0.013001532,0.019820362,-0.043195084,0.012983411,-0.024064748,-0.04189039,-0.013938852,-0.03519434,-0.07585831,-0.019160958,-0.0672343,0.023596302,0.0020135134,0.14255698,-0.064100094 +2.1.1.251,"The enzyme, which is involved in methanogenesis from methylated thiols, such as methane thiol, dimethyl sulfide, and 3-(methylsulfanyl)propanoate, catalyses two successive steps - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to CoM. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90, methanol---corrinoid protein Co-methyltransferase, and EC 2.1.1.246, [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.",384,1.0,-0.008968511,-0.03006508,-0.17159559,0.01171628,0.1280638,0.006506827,-0.08351591,0.03393276,0.0053485776,-0.053452034,-0.0027758994,-0.077077106,-0.060204506,-0.04508998,0.0035592767,0.06741758,-0.061460365,-0.012373157,0.0038170593,-0.02498767,0.079841115,-0.025139792,-0.09367989,-0.014394467,-0.027555149,0.009330157,0.045070365,0.01780809,0.03421439,-0.011644601,-0.016994817,-0.024121094,0.027079158,-0.0042794202,-0.006682526,0.09204772,0.0032890295,-0.06728744,-0.0059788274,0.022577234,0.04473726,0.030312404,0.03365797,-0.027235815,-0.016947035,-0.03699844,0.006481821,0.06299508,-0.07467141,-0.058224753,-0.038122673,-0.07000931,-0.04584254,0.067425996,-0.019302825,0.08156067,-0.058975738,-0.0053908587,0.029227657,-0.0047098794,-0.007314782,-0.019117195,0.012579637,-0.022661539,0.08377799,-0.028855477,0.030847322,-0.09882888,0.073047236,-0.061306532,-0.043731097,0.001586594,-0.037576668,-0.05355466,-0.025865009,0.031283025,0.024665255,-0.014783319,0.07568889,-0.07763757,-0.017906755,0.12608601,0.062337752,-0.062659286,0.033470176,-0.010883857,-0.054794878,0.027632542,-0.02074176,0.00847152,0.048298806,-0.023079818,-0.032768734,0.035508107,-0.09067812,-0.008118368,0.14367586,0.09873996,0.06918766,-0.005137062,-0.0017224291,0.09914076,-0.09303159,-0.023692131,-0.039518926,-0.01046266,0.09104906,0.14472504,-0.024687555,0.09698068,-0.0056301267,0.053193577,0.05892643,0.014664876,0.010700029,0.10169749,0.012779461,-0.034910608,-0.014305958,0.012603959,0.05791207,-0.0016027825,0.03344064,-0.052292492,-0.0064374437,-0.0145812575,-0.027179018,3.4090104e-33,0.088038504,0.050484587,-0.034298323,-0.011218803,-0.015329544,-0.0153052155,-0.079337716,0.060175642,0.051748093,0.0120708,-0.028582687,-0.009147356,0.040777978,-0.004262197,-0.06767444,-0.06125069,-0.014649579,-0.039561857,0.03344035,0.04465371,-0.019374682,0.077681005,-0.043925617,0.02099622,-0.0024682235,0.022138717,-0.048388965,0.021249225,0.038356554,0.012073997,-0.024883104,-0.074535355,-0.09853484,0.0015017828,0.05131419,-0.009176228,-0.048353788,0.0033298428,-0.020818831,0.035528984,0.058311053,-0.017813824,-0.04263218,-0.023152748,-0.016411044,-0.07041322,-0.051553037,0.054738406,0.04438052,-0.051686417,-0.012668286,-0.0018413967,0.08414027,-0.07431978,-0.07692995,-0.055766534,-0.03494934,-0.0825567,0.01741562,0.055623353,-0.028022254,0.02016709,0.030642282,0.08996951,-0.010708378,-0.012546297,-0.075814314,-0.043693688,0.062182162,0.048891645,-0.040708642,0.0067954576,0.04124333,0.03300361,0.0010076881,-0.07152466,0.03762339,-0.010241676,0.059477873,0.0009277588,0.050119042,0.054554224,0.03873859,-0.07842146,-0.035733107,-0.00087991485,-0.06388321,-0.088519335,-0.035814207,0.0016350881,-0.049713645,-0.007760117,0.01740467,-0.01813249,0.025100514,-5.0668556e-33,0.06471578,-0.06640215,0.05319328,-0.11874315,-0.07871821,0.098433495,0.012215097,-0.06961228,0.018484313,-0.092453554,0.09926882,-0.004510893,0.0132371485,-0.02230222,0.053438496,0.010441878,-0.049928647,0.13747768,0.014275883,-0.034642193,0.03892588,0.06858003,-0.05977464,-0.020668594,0.04170254,0.012118994,-0.07623361,0.0120885195,0.09593396,0.10601691,0.01707833,-0.020486671,-0.027822912,-0.012739945,-0.04476658,0.03485162,-0.031264924,0.013709262,0.019989366,0.032274745,0.01751702,-0.028269157,-0.008859304,0.045883276,0.065172955,0.054870725,-0.11572781,-0.045041043,0.009713746,0.00090623135,0.027316066,-0.032540556,-0.14293846,0.023626331,0.028807638,0.08832932,0.027265288,-0.0041885125,0.035507757,-0.094127715,-0.05359416,-0.023281991,-0.020709535,-0.05106596,0.05792361,0.029027604,-0.022081757,0.010210255,0.076556146,0.033796754,0.026676878,0.11436011,-0.012896403,-0.042612102,-0.03670692,-0.06793667,-0.06894647,-0.010405459,-0.070929274,-0.026010908,0.009936257,-0.0028901824,0.08346922,-0.03378729,-0.054401353,-0.01712341,0.07753145,0.038215656,-0.06222139,0.012927852,-0.06714361,-0.074822955,-0.059384346,0.028063472,0.007268406,-5.2952576e-08,0.0045145843,-0.055150617,0.040606175,-0.00072959816,-0.010699519,0.12544064,-0.017872816,-0.05467142,0.029655686,0.01578865,-0.02810814,0.058029696,0.045412786,-0.017845735,-0.031221215,0.0069212704,-0.04406446,0.004972665,-0.000838112,0.006159188,-0.02002624,-0.019883972,0.012564866,0.057726804,0.05891125,-0.045547023,0.036070835,0.087166615,-0.02562604,-0.035821103,-0.018903825,0.033058096,0.051194858,0.030320726,-0.027384201,-0.0044373553,0.011340091,-0.0021286614,-0.06386348,-0.0024738705,0.019413857,0.00017710926,-0.08094909,0.06720857,0.069216594,-0.053332567,-0.022338169,0.09894225,-0.029400213,0.01212256,-0.015720818,-0.041763145,0.016027052,-0.029021066,-0.0156669,-0.019483011,-0.04727572,-0.018329695,0.009578372,-0.010315632,0.03742814,0.019033942,0.13806818,-0.09071682 +2.1.1.252,"The enzyme, which catalyses the transfer of a methyl group from tetramethylammonium to a tetramethylammonium-specific corrinoid protein (MtqC), is involved in methanogenesis from tetramethylammonium. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.253, methylated tetramethylammonium-specific corrinoid protein:coenzyme M methyltransferase.",384,1.0,-0.03715759,-0.00701834,-0.16083542,-0.0046177236,0.08912971,0.036367554,-0.059826188,-0.0037181596,-0.004865957,-0.045601036,0.017522518,-0.09646621,-0.052885037,-0.019407308,-0.036945924,0.061810113,-0.035227813,-0.025162248,0.024608804,-0.053810004,0.055940833,0.0036187589,-0.07407628,-0.045213558,-0.020425454,0.044068955,-0.0021248793,0.04112822,0.07504398,-0.020602364,0.006968511,0.037335657,-0.018238995,-0.022280388,0.017718354,0.1170145,0.01145672,-0.11162004,0.021191569,0.026779754,0.064908534,0.053026907,0.058214206,-0.06538178,-0.008283237,-0.0024196112,0.007107581,0.03883054,-0.039764103,-0.054544818,-0.018466413,-0.08047241,-0.068752244,0.04092598,-0.010873888,0.087134905,-0.03833118,-0.025393015,0.01390046,-0.0013687442,0.042060215,0.014592081,0.043188065,0.019027827,0.11340081,-0.039242193,0.013889941,-0.08367608,0.062486753,-0.08779956,-0.035922896,-0.02227799,-0.05856167,-0.05896366,-0.018545317,0.04361964,-0.008763682,-0.07794019,0.04139876,-0.017920462,-0.03363459,0.09019298,0.024740225,-0.047301188,0.055381704,-0.008711559,-0.06308207,0.02227491,0.003521567,0.03278349,0.042203657,-0.024259934,0.037195332,0.035548627,-0.06521144,0.035065033,0.10304197,0.040693846,0.029384298,-0.011701952,-0.022011284,0.09470086,-0.09124073,0.017430352,-0.023322258,-0.019117195,0.10261257,0.15031494,-0.016213082,0.07948261,-0.03165195,0.06244255,0.048990343,-0.029143233,0.03022839,0.06327476,0.03623258,-0.019008981,0.012845392,-0.01350625,0.05627609,-0.047210574,-0.029932667,-0.012896048,0.030670319,0.03708079,-0.07025644,5.8197733e-33,0.120031744,0.05717259,0.008287543,0.021476397,-0.024489086,-0.005249108,-0.032572113,0.025721224,0.055763192,-0.04094541,-0.074774064,0.0113638565,0.05392986,0.015260974,-0.08567644,-0.03848453,-0.07855758,-0.03994522,0.022970622,0.032830402,-0.029831735,0.05438991,-0.015123081,0.021907046,0.0048141046,0.02837942,-0.063059546,0.0106314365,0.0623634,0.014210485,-0.042920392,-0.0379796,-0.13703546,-0.0059816986,0.058537308,0.019265378,-0.052521832,0.0056288913,-0.02127347,0.056869037,0.073430456,-0.025819384,-0.029685598,-0.009033262,-0.0051670466,-0.066468544,-0.040872235,0.02186595,0.027079614,-0.058211204,-0.0033926908,0.0132788755,0.032769416,-0.07853203,-0.0713222,-0.057888504,0.0021820972,-0.028142964,-0.0346696,0.06263697,-0.04294686,-0.0074790167,0.023773152,0.09434203,0.0012175997,-0.03779855,-0.048561167,-0.08625286,0.07008454,0.015222388,-0.010809369,-0.027165854,0.0596442,0.065340064,0.033559345,-0.07398201,0.03146084,-0.04321019,0.055745944,-0.010998809,0.06565407,0.04009014,0.051545538,-0.0964079,-0.03957344,-0.029151252,-0.022566695,-0.070342585,-0.0053198254,-0.01491174,-0.015650298,-0.0037714862,0.031408437,0.0022537992,0.003954932,-6.488854e-33,0.0588026,-0.07180977,0.046172213,-0.102065936,-0.10432018,0.04984023,0.023136325,-0.0649181,0.022058487,-0.021447362,0.13580506,-0.038683217,0.015584523,-0.013059041,0.04801253,-0.03527443,-0.039629556,0.11678071,0.01759954,-0.010695844,0.029398922,0.03858356,-0.029547328,-0.020380352,0.045514967,0.02614738,-0.065383166,-0.031581763,0.031831563,0.051677838,-0.029595658,-0.06251059,-0.027781231,0.019763038,-0.054784272,0.044279594,-0.04240803,0.0141278105,0.0057016313,-0.00830058,0.02801957,-0.02058099,-0.015297351,0.056693964,0.03884041,0.021924479,-0.105161615,-0.04148308,0.03327394,0.05594775,0.047268715,-0.0062453696,-0.07224858,0.006159238,0.021507591,0.08759999,0.041592736,0.011549788,0.05797915,-0.056162257,-0.032323737,0.007770837,-0.023869108,-0.067346215,0.09359148,0.05571049,0.03286849,0.02356883,0.07453625,0.0004223872,0.031326503,0.10345837,0.03841179,-0.049788795,-0.02583273,-0.11030283,-0.108656704,-0.0002787079,-0.05824967,-0.06560996,0.0019432801,-0.006852239,0.07183661,-0.027232511,0.0038814424,-0.001272632,0.08951024,0.03631906,-0.0680125,0.015420784,-0.028527496,-0.07548312,-0.0332082,0.02596986,0.03961825,-4.3454214e-08,-0.0020738926,-0.04121655,-0.0076130317,-0.038971167,0.019372411,0.131019,-0.03818389,-0.09740047,0.0739867,0.04959191,0.006177382,0.02489244,0.054379743,0.04577175,-0.040082954,0.017016737,-0.07582318,-0.012160252,0.006155985,-0.004110059,-0.047784697,0.00987382,-0.0246518,0.03374922,0.020871405,-0.03973808,0.03728353,0.17644276,0.010294579,-0.02959508,-0.05075892,0.012577825,0.032780472,0.022007713,-0.069994174,0.004228107,0.040767252,-0.002093194,-0.08955989,-0.030156905,0.008296727,0.03455164,-0.07824067,0.019543331,0.06712924,-0.045627028,-0.05576051,0.08479998,-0.05005728,0.056032505,0.01232462,-0.057899497,0.016629215,-0.03595946,-0.037282776,-0.057236824,-0.03637256,-0.036512207,-0.016984258,-0.014402985,0.008287511,0.018651413,0.10449554,-0.101199985 +2.1.1.253,"The enzyme, which is involved in methanogenesis from tetramethylammonium, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.252, tetramethylammonium---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis.",384,1.0,-0.049048822,0.01480128,-0.16190037,0.00915688,0.07730468,0.03336025,-0.056091443,0.015265961,-0.019600652,-0.055553783,0.025330175,-0.09455996,-0.06779081,-0.03110789,-0.023833243,0.08785961,-0.08281763,-0.038218413,-0.0077038966,-0.07538258,0.07492555,0.0016670016,-0.058286157,-0.035400316,-0.028184162,0.02762004,0.0007086738,0.00050547003,0.07320427,-0.0026791776,0.0029025362,0.009757851,0.011655573,-0.010310366,0.03203641,0.108232245,0.04186661,-0.057827983,0.0007991948,0.0280281,0.047035553,0.05401937,0.027951756,-0.036646176,-0.0041506854,-0.019697756,0.033304434,0.039051082,-0.027271181,-0.09421473,-0.06541746,-0.06013542,-0.026960295,0.04086703,0.019088235,0.08263146,-0.019208226,-0.033547517,-0.00235459,-0.008153627,0.042544626,-0.0034721186,0.0117069725,-0.012643973,0.084658705,-0.043920897,0.047071185,-0.08916749,0.07453184,-0.04662826,-0.07355876,-0.0040994724,-0.07920825,-0.042008862,-0.032335512,-0.031602014,-0.0016977878,-0.04808362,0.08640343,-0.01985689,0.0029064761,0.08531524,0.012221205,-0.043237492,0.045742728,-0.008925938,-0.06422335,-0.0006954824,0.015987968,0.03820061,-0.027855974,-0.053703163,-0.011228711,0.064006664,-0.1083615,0.039216384,0.123802684,0.05687632,0.06474998,0.018997228,-0.022323193,0.080022745,-0.11483176,-0.013798732,-0.068363085,-0.043884348,0.093019456,0.13249625,-0.0026046105,0.08356524,0.022992052,0.026433786,0.062405933,0.00959293,-0.009733396,0.08267311,-0.00038058925,-0.031863444,0.035817456,0.012529226,0.07573891,0.012175362,0.008307192,0.023034593,-0.016571894,0.024244798,-0.08425706,2.4476805e-33,0.1272138,0.08442131,-0.0040200567,0.026728218,-0.037270732,-0.023772774,-0.07443811,0.06269704,0.02779639,-0.010073917,-0.094445564,-0.02660434,0.04788254,0.0074040904,-0.06730064,-0.062534906,-0.043384574,-0.030159002,0.028153671,0.040735207,-0.041072488,0.043851063,-0.03953299,-0.0012744942,-0.00083775766,0.027536813,-0.046546478,0.024318855,0.059744887,0.024758365,-0.017344926,-0.050621666,-0.112374134,0.012989925,0.047772817,-0.0018260007,-0.061395302,-0.010752824,-0.018593296,0.031792965,0.08307589,0.004993865,-0.027892943,-0.030342052,0.026676947,-0.019036442,-0.053981915,0.06448909,0.08680204,-0.022576693,-0.040983368,0.015479014,0.061963618,-0.078204826,-0.09261369,-0.052854102,0.0054461374,-0.051020097,-0.003643777,0.058020186,-0.05070727,0.002939481,-0.0050708284,0.07091014,-0.033368487,-0.030433891,-0.03773632,-0.07622401,0.03958758,0.028159369,-0.06787898,0.009612593,0.019683804,0.060472425,0.026071245,-0.06911692,0.048957612,-0.03642899,0.064978264,0.00835276,0.038591877,0.037234094,0.029472683,-0.095325716,-0.05190815,-0.014440762,-0.059510697,-0.07384895,0.004644092,-0.0068717124,-0.037105408,-0.02882279,0.007552365,0.021118516,0.039962642,-4.4670115e-33,0.05365439,-0.061773267,0.014777881,-0.13033643,-0.08566587,0.06527129,0.0072894837,-0.060304876,0.036520746,-0.0025608726,0.10979025,-0.021076774,0.06909219,0.010185315,0.04517196,-0.02924444,0.0032172839,0.10192319,0.03830016,-0.02046548,0.056666356,0.06792947,-0.052788015,-0.04648025,0.011789153,0.0034458637,-0.04379652,0.02334943,0.055568445,0.07644402,-0.002749936,-0.0846315,-0.04957242,0.020613533,-0.08902922,0.053005394,-0.051163983,-0.018691136,0.0065479022,0.0034123359,0.022509573,-0.010322434,0.009378623,0.05155026,0.041699573,0.058478758,-0.09595219,-0.016610833,0.006123661,0.0007999156,0.05792505,-0.0028738764,-0.0777168,-0.034317397,0.015813412,0.08661005,0.049062688,-0.008487772,0.039383244,-0.05522484,-0.04185432,-0.024003686,-0.01259763,-0.028749833,0.044022597,0.049882364,0.012419845,0.007351858,0.060845796,0.005198978,0.03578755,0.106319144,0.0042151613,-0.022938099,-0.05937214,-0.08324634,-0.10995662,-0.024443848,-0.0724595,-0.05010222,0.0036414082,-0.0025815486,0.108756326,-0.042024124,-0.016602118,-0.054018572,0.07877147,0.059108756,-0.05323985,0.03679014,-0.06146977,-0.04198558,-0.05404521,0.025158066,0.021552665,-4.4448075e-08,-0.021151163,-0.06325641,0.02188184,-0.02079824,0.013304115,0.12628075,-0.0008218463,-0.05426187,0.05492149,0.0070442236,-0.025423909,0.057349782,0.052682534,0.032823086,-0.04076728,0.025078103,-0.05619348,-0.01340933,0.0039612707,0.0003472664,-0.021255419,-0.0152651025,-0.017332854,0.02654852,0.009889239,-0.058101833,0.036354348,0.14622726,-0.003183599,-0.092370845,-0.023801472,0.034575537,0.028780567,0.046732955,-0.108637795,0.004876835,-0.0045801075,0.0064067584,-0.06103302,-0.016007394,0.034636162,0.037267797,-0.06246989,0.045150395,0.061593443,-0.040886357,-0.045256115,0.04829796,-0.030797785,0.025751578,0.039440013,-0.038660467,0.016551789,-0.033600852,-0.038600057,-0.060168114,-0.06285046,-0.022846626,-0.006442251,0.0074406597,0.04074235,0.03556532,0.119888164,-0.07908086 +2.1.1.254,"The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154, erythromycin 12 hydroxylase.",384,0.99999994,-0.010051782,0.011183275,-0.11385924,-0.06271649,-0.0061644623,-0.010348722,0.0075377254,0.04526567,0.036941808,0.00486049,0.030903623,0.011695142,0.037421394,0.02234356,0.04959443,0.06873051,-0.07248311,0.056234326,-0.037406214,0.006137084,0.020647999,0.019594396,0.06622458,0.022870224,0.05402246,-0.05505846,0.043273643,0.06699031,-0.013862805,-0.10129559,0.012431567,-0.015846482,0.052188452,-0.029913522,0.07636762,-0.0018890799,-0.054849464,-0.03088268,0.08241356,-0.000814295,0.011836009,0.0009630064,0.01640112,0.039400913,-0.07400128,0.0037944117,-0.04626475,0.010796267,0.0013908268,-0.011314432,-0.027302535,-0.039525785,-0.09445773,0.06588599,0.032928977,0.026869463,-0.028865622,-0.0042408295,0.007505951,0.018122403,0.074247785,0.023639962,-0.010375461,-0.02748137,-0.09565696,0.012949359,0.03295252,-0.1265207,0.0077511077,0.00562655,-0.09985553,-0.10528482,-0.090427645,0.06950833,0.060903393,-0.08212369,-0.011396118,0.037989978,-0.0101699075,-0.051341213,-0.0021476205,-0.0021175602,0.01415893,0.07228633,0.042253565,0.00419193,-0.0003215986,0.019217271,0.054838113,0.019699397,0.032066263,-0.041252267,-0.032907367,-0.03596421,-0.015224777,0.013500709,0.003632618,0.023285767,0.06890444,-0.0077802595,0.02008008,0.0128441155,-0.13828892,-0.0007237868,0.0066339844,0.032973707,0.007882227,0.07137619,-0.05281586,-0.064296685,-0.000113256305,-0.0041907933,0.04609386,-0.008269322,-0.06771679,0.07968405,0.122213535,-0.023206498,-0.042589776,-0.031132873,0.057215173,0.027846599,0.073424585,0.007925533,-0.047913555,-0.053014107,-0.110218324,4.780753e-33,0.001483782,0.0694497,-0.028574854,0.0019307429,0.027721226,0.049769204,-0.03873595,0.028945524,0.0018667722,-0.06739373,-0.08541518,-0.121025056,0.01401808,0.08029231,-0.08275378,-0.008909468,0.040022966,0.027642481,-0.017654214,-0.019712374,0.021602185,0.05346044,-0.02139342,-0.04716233,-0.03623525,0.07997699,-0.016262418,0.054072775,0.09812571,-0.037295297,-0.004690074,-0.13514765,-0.045104086,0.01273748,0.034969278,0.031167837,-0.030296117,0.03260324,0.1398438,0.052880555,-0.039177172,0.046705388,-0.009533032,-0.015645714,0.03851334,0.010411364,-0.038341876,0.08939949,0.08176982,-0.0051685567,0.032589737,-0.04696638,0.10156658,-0.053060785,-0.06279328,0.03371456,0.022580428,0.06005247,-0.03001901,0.02146734,0.03409349,-0.0024645529,0.020921918,0.039492223,0.0055429204,0.021559035,-0.055852998,-0.06861937,-0.042252157,0.044485554,-0.047390644,-0.02877107,0.10438425,-0.004525012,0.032796893,-0.0044197417,-0.12989905,-0.00039083345,0.025141321,0.0014371214,-0.06354977,0.08282817,-0.027310241,0.0049998234,-0.03241906,-0.024183974,-0.048707925,-0.075725436,0.0059933844,0.0626148,-0.059655618,-0.09890857,-0.056766145,0.014747186,0.04588132,-5.3450573e-33,0.08925577,0.011505922,0.08418639,-0.08634509,1.8059658e-05,0.0337996,0.067456834,-0.033811398,-0.012050479,0.03774675,0.13872364,0.020047033,-0.10525567,-0.06305292,0.008443062,-0.024545165,0.003963591,0.09066422,-0.038043838,0.03028533,-0.04983432,0.058630694,-0.056461494,0.037739202,0.032672882,0.041194465,0.0058921003,0.057315018,0.088331245,0.02766125,-0.063870616,-0.058866076,-0.018541398,-0.029160855,-0.0007005026,0.14699605,-0.076470874,-0.035775635,-0.05594974,-0.031641595,0.022732306,-0.012568411,-0.022106694,0.05016831,0.041671697,0.033786125,-0.082525,0.0854662,-0.024253687,-0.048821785,-0.022644395,0.021240227,0.039971955,0.04229447,-0.0021355601,0.017722378,0.05872986,0.009736554,-0.019865476,-0.025854712,-0.09455001,-0.014305542,0.075702645,-0.026010454,-0.02468628,0.015579232,-0.05530711,0.04750936,0.07166012,-0.038162008,0.057600204,0.02638368,-0.06657046,-0.011595636,-0.0709717,-0.05864361,0.0049547916,-0.055421215,-0.011074983,0.009211523,-0.0010257183,0.014693399,-0.034436937,0.003410244,-0.037955467,-0.026261441,0.0152561115,0.019344313,-0.0115611125,-0.0030141617,0.0714239,0.063703366,-0.039163362,0.0833543,0.03664012,-4.0780243e-08,0.032349735,-0.04362658,0.039198004,-0.038517125,-0.015840672,-0.044099946,-0.052649464,4.663015e-05,0.012906507,-0.01527147,-0.047504373,0.06578038,0.016988492,-0.04753557,-0.0122634955,-0.004741761,-0.03980402,0.0492799,0.0018085447,-0.004400632,-0.05710012,0.017485354,-0.07708634,-0.03182064,0.05840641,-0.048515566,-0.056909423,-0.031316496,0.020997638,0.056833502,0.13006747,0.0007586282,-0.011883361,0.049835205,0.0051956647,-0.02402491,-0.13345562,-0.04853751,0.0019440925,-0.0067673633,0.071334265,-0.018595127,-0.10198784,0.061804935,-0.011669092,0.011054601,-0.088038564,-0.054197468,-0.004160174,0.018692298,0.055404376,-0.016425477,0.0104483375,-0.04387418,-0.101841785,0.050064087,-0.041385908,-0.023078963,-0.0075145746,-0.020521065,0.03619741,0.007354286,0.1571639,-0.019008936 +2.1.1.255,"This enzyme, along with EC 4.2.3.118, 2-methylisoborneol synthase, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odour.",384,0.99999994,0.059994478,-0.011490698,-0.021753717,-0.042584788,0.07507956,-0.004669321,-0.095791474,0.017670115,0.044311415,-0.07319756,0.028513279,-0.11938196,-0.043478966,-0.04998603,-0.022943031,0.08896882,-0.066086404,-0.016250247,0.024026483,-0.031064404,0.08399217,0.10211701,-0.010203456,-0.017260661,-0.086648114,0.036090225,0.04736152,-0.008922488,0.035270438,-0.07887186,0.068313494,-0.013834057,0.08985168,-0.07549218,0.028976101,0.028324718,0.01223962,-0.05437349,-0.0064846096,0.07655362,0.04541832,-0.06041775,0.01936162,-0.0513888,-0.09246248,-0.090647526,0.026923968,-0.036935426,0.01877904,-0.045203593,0.0021702186,-0.074961506,-0.018622743,-0.0022259753,0.01504365,0.021180509,-0.05662008,-0.028499562,-0.075598896,0.006708078,0.066424966,0.054445937,-0.0055168364,-0.04790772,0.04638112,0.02026385,0.04842944,-0.08362262,0.04587722,-0.031297185,-0.15249966,-0.076807186,0.0009551907,0.08294991,-0.01851036,0.043334592,0.032027803,-0.049523607,0.13300043,-0.096257076,-0.0051410254,-0.0023214936,-0.024937289,-0.032084964,-0.020131284,0.010043351,0.007627029,-0.015411494,0.09863048,0.024446273,0.04768735,-0.07268552,0.001966697,-0.021028446,0.035919916,0.08786522,0.038854856,0.059899136,0.04675991,-0.016087132,-0.010636819,0.076764524,-0.14532743,-0.1001558,-0.022456482,0.022393726,0.0012423913,0.028445492,0.02138161,0.054778695,-0.0075653573,-0.038220383,0.00052520155,-0.063852474,-0.029541206,0.061667603,0.031901408,0.004375415,-0.070632406,0.011976836,0.020711279,-0.024631869,0.037616126,0.05478023,0.05049136,-0.044404037,-0.027512396,7.894985e-34,0.036318492,0.050041135,-0.02610726,-0.021351904,0.02190547,0.0129003655,-0.071292244,0.05706558,-0.043833394,-0.02653476,-0.048873685,-0.03769318,-0.040082995,0.08089962,0.007824577,-0.030474266,0.039339572,-0.016403085,0.08178064,-0.028012011,-0.022640692,0.022112278,-0.033131946,0.012790344,-0.04798247,0.037296798,0.03850331,-0.001050936,0.06590519,-0.016405394,0.048281364,-0.059778806,-0.090967014,0.0006913326,-0.017966202,0.009038341,-0.06781049,0.0069888607,-0.021978045,0.08058845,0.06146066,0.04360731,0.05967642,-0.031361803,0.057496406,-0.05872459,-0.079045966,0.04395376,0.14443827,0.011455563,0.015704066,0.005424819,0.051293485,-0.0016188493,-0.012748452,-0.043818023,-0.033842687,-0.007350035,0.028210323,0.019477455,-0.036983166,0.1279759,0.014196863,0.03531593,-0.007870435,-0.08512134,0.017456472,-0.0048570363,0.010400644,0.039390348,-0.024772203,-0.02901314,0.059897896,-0.007188574,0.00074365025,-0.06344079,-0.09557967,-0.040627107,0.06111162,-0.007853896,-0.076762214,-0.014970818,0.030052762,-0.013423592,-0.079367615,0.0030579667,-0.07422124,0.0523129,0.030546797,0.117196314,0.008584095,-0.0759178,-0.063403346,0.06313745,-0.012339929,-2.4531928e-33,0.016127674,-0.029698737,-0.0096505,-0.054657556,-0.053002033,0.065736756,0.027012065,0.054833375,-0.06203311,0.0374631,0.07962776,0.051538937,0.10672597,-0.053780276,0.06770308,0.008753165,0.0070388573,0.041845486,0.00053554645,0.0073265466,0.055572707,-0.014340185,-0.018307924,0.060781684,0.030336153,0.04462546,0.086043425,0.053176682,0.0053838207,0.016822614,0.008127138,0.029530132,0.012742455,-0.039925188,-0.042222254,0.021740237,-0.018907791,-0.057680663,-0.034202147,0.021393215,-0.038377907,0.039939,-0.036012616,0.046495367,0.010875234,0.05399901,0.02149006,-0.01807815,0.081174456,-0.060178433,0.063338764,0.055223703,-0.028352374,0.026294567,-0.008525978,0.0027549716,-0.09612279,0.01024497,0.012004763,-0.0136617245,-0.043597117,-0.017342743,-0.0075302017,-0.04104333,0.042913876,0.06327903,-0.04220445,0.024524897,-0.0030735994,0.050243374,0.04981929,-0.00950922,-0.005973481,-0.016100034,0.005778784,-0.042971253,-0.017342245,-0.09493523,-0.061470665,-0.037325952,0.013833696,-0.048940353,0.066593766,-0.016941534,-0.044715844,-0.09291725,0.037755582,0.09824911,-0.01565311,0.084740624,-0.0043983,0.060407866,-0.14086725,0.029963212,0.07189694,-3.7193598e-08,-0.02024345,-0.12003882,0.072384275,-0.046082735,0.03138495,0.0608772,0.00649067,0.040868405,0.029226325,-0.017365217,-0.04651634,0.009578105,-0.0042766086,0.033425786,0.11001678,0.0021456815,-0.029045237,0.0153537365,-0.025773637,-0.062378008,-0.051707823,0.011931314,-0.041012816,-0.03724612,-0.0084595075,-0.046570186,0.015414834,0.04134792,-0.018038386,0.03807069,0.07228264,0.067738794,-0.018775418,0.0137155475,-0.115699016,0.017140985,-0.018473422,-0.06924575,-0.051908657,-0.007916204,-0.018044226,-0.02678553,-0.077334486,0.007925449,0.04503549,-0.04663808,-0.04827749,0.02631588,0.028664686,-0.048797783,-0.0022891718,-0.052309692,0.020461664,-0.0061527453,-0.011953101,-0.06055527,-0.07659429,-0.09290881,0.03641932,0.009041634,0.07187827,-0.0382219,0.15623303,-0.07479733 +2.4.1.279,"The enzymes from Clostridium phytofermentans is specific for nigerose, and shows only 0.5% relative activity with kojibiose (cf. EC 2.4.1.230, kojibiose phosphorylase).",384,1.0,0.014658865,-0.04962165,-0.07177587,0.009143615,0.079485506,0.019492637,-0.024205646,-0.028769555,0.011604488,0.0058422363,-0.034135915,-0.058669295,-0.022338541,0.10413101,-0.049308863,0.014935736,0.0069841607,-0.011822135,0.030455714,0.017029319,0.07213481,0.026568875,0.09135506,-0.015472964,0.056957208,-0.07688157,0.056997802,-0.050600596,-0.012184176,-0.03958422,0.01242819,-0.028767275,0.04030004,-0.023176413,0.061665904,0.034896582,0.0040453477,-0.056672487,0.121004105,-0.0099405395,0.036093045,0.014663962,0.009343345,-0.036979932,-0.041368682,0.022858616,-0.03802571,0.013458727,0.01024899,-0.04695897,-0.081782386,-0.08300982,-0.028437883,0.016995642,0.06726634,0.020252839,-0.06337072,-0.042956416,0.03613189,-0.0022855615,0.0346722,-0.021345332,0.03310068,0.026455663,-0.0020567055,-0.08331975,0.052692086,-0.019420661,-0.012412809,-0.057357144,-0.0036570928,0.006339321,0.013534806,0.021758704,-0.004558945,0.05525088,0.010289073,0.015461818,-0.079820864,-0.11442588,-0.01512452,-0.042532176,0.046328846,0.020695014,-0.019651808,-0.026224133,0.040325392,0.042602006,0.05861775,0.020488227,0.09175094,0.019151697,0.053046137,-0.048298765,0.009590469,0.015898911,-0.023361394,0.05232476,0.0085048005,-0.049147878,-0.045303855,-0.0083627375,0.03703169,-0.048589386,-0.07744891,0.014934879,0.03602962,0.08169065,0.040293634,0.0038884345,0.021114038,0.042633645,0.087896585,0.061832096,0.020768318,-0.0617038,0.04905341,-0.0723749,-0.019713124,0.076305516,-0.005469359,-0.028219145,0.055044204,0.027173793,-0.043607656,0.11706546,-0.030061891,2.8342126e-33,0.06937111,0.041640565,0.013511124,-0.11776429,0.010262379,-0.027527682,-0.10600284,0.050761886,-0.008365651,-0.04738636,-0.11144193,-0.039681915,0.055249788,0.024003895,-0.021847628,0.050472654,-0.022353446,0.018354274,0.08802174,0.020843036,-0.0312545,0.008094558,-0.03513222,0.031030651,0.05502889,0.01652158,-0.013948515,-0.019487418,-0.039156888,-0.038242087,0.09990408,-0.08139156,-0.049065467,-0.026400354,0.0054326444,-0.0081973,-0.009929811,-0.02532599,-0.1006119,0.018692136,-0.015859956,0.03449174,-0.037626494,-0.03277439,-0.014093898,-0.04494476,-0.05800494,0.12882222,0.047319185,0.110322244,-0.02641371,-0.014974718,0.071127005,-0.036861606,-0.025873668,0.0496308,0.021543035,-0.019419158,0.13933797,-0.002967294,-0.0068799495,0.053512264,-0.0363691,-0.02545865,-0.0007390884,-0.011876823,-0.04183585,-0.044202153,-0.0081825275,0.047827832,-0.08031214,-0.05136107,-0.016927417,0.01887637,0.024285892,-0.05686669,-0.047204804,-0.11784049,0.0057081985,0.075124435,0.009879254,-0.070289984,0.008262932,-0.035920296,-0.056338437,0.014742909,-0.11348724,0.035459705,-0.06622205,0.015665779,0.02470985,-0.08763873,-0.09878566,0.042236492,-0.018369643,-2.909939e-33,0.079953335,-0.011736184,0.051976666,-0.0062984196,0.0052048173,0.06583909,-0.0060811397,-0.0053273253,0.006289032,-0.049499422,0.089784026,0.032762542,0.022869704,-0.022311063,0.033087578,0.021741671,-0.027083613,0.1112554,-0.038010217,0.009096843,-0.046146754,0.083928384,-0.016346416,0.032065324,0.06839882,0.08948668,0.009254817,0.113793656,-0.010115645,0.013494275,0.047705323,0.040561687,-0.033722714,-0.05458155,-0.02359926,-0.010559886,-0.021248737,-0.020664643,0.0119625805,0.00589341,0.05866749,0.13736019,-0.052193623,0.044987205,-0.01991375,0.05357334,-0.025300017,0.011109126,0.04518628,-0.013925737,-0.032266058,0.07472721,-0.0013112709,-0.040117122,0.083312355,0.020747725,0.011373775,0.018493783,-0.026122086,-0.101364695,-0.062965326,-0.012197915,0.07492572,0.039665867,0.08128849,0.0832892,-0.03987433,0.08588917,0.063075714,-0.046354607,-0.051860616,-0.053849965,-0.0027555695,-0.03379032,-0.105208784,0.068838,-0.07091078,-0.032593273,0.024996495,0.0641925,0.05925911,-0.025178183,0.042154294,-0.10002399,-0.02893929,0.027294505,-0.046621945,0.04362288,0.099844016,0.035815895,-0.065779045,-0.09379796,-0.02545526,-0.020863963,0.016141942,-3.4453773e-08,0.071329184,-0.05630704,0.06951585,-0.032247752,0.024208987,0.008458669,-0.038370606,0.04219518,0.003979589,0.011053757,0.02443771,0.02723956,-0.019820256,0.056457818,0.04975008,-0.034910172,-0.007905936,-0.009459394,-0.050254855,0.028131546,-0.05207418,-0.070533715,-0.08232998,0.1295061,0.06472521,-0.07603756,-0.047855034,0.0313473,0.0072944383,-0.013390308,-0.007090968,0.008609756,0.023252307,0.01819268,-0.032299694,-0.006827877,-0.031098554,-0.02224263,-0.064468466,0.05163188,0.019588929,-0.11036066,-0.05247815,-0.01887997,-0.056268502,-0.026154742,0.025767725,0.022160629,-0.034833983,-0.09511162,0.023502117,-0.05157104,-0.10406889,0.034499668,-0.04825492,-0.018482964,0.0075718807,-0.066319264,-0.049915824,-0.09600171,0.038164835,0.019172003,0.14505519,-0.06677584 +2.4.1.280,"The enzyme is specific for N,N'-diacetylchitobiose and does not phosphorylate other N-acetylchitooligosaccharides, cellobiose, trehalose, lactose, maltose or sucrose. ",384,1.0,0.03785735,-0.11345741,-0.06906235,-0.011344678,-0.06027788,0.042629912,0.018603807,-0.026357595,0.018556522,-0.051677767,-0.010311132,-0.023163693,-0.09681529,0.07537661,-0.088702664,0.011473546,0.025174929,-0.0070113586,0.012263291,-0.016583372,0.13619179,0.02063382,-0.013614369,-0.016451541,0.04400784,-0.034324307,0.08195628,-0.06956239,-0.043389317,-0.086992234,-0.050988954,-0.08854931,0.067390844,-0.0033105973,0.10348553,0.062871106,-0.0018188888,-0.005400039,0.05259858,-0.006981653,0.01811784,0.03009662,0.025823243,0.084939316,-0.0022343716,-0.03929487,-0.03180758,0.03986224,0.013562761,0.020605667,-0.06737641,-0.073807396,-0.023225497,0.062495258,0.039666366,0.08274818,-0.066423655,-0.0055497773,0.014731482,0.02525908,0.026764197,0.011695846,0.045475457,-0.016491326,0.083191976,-0.037104268,0.0431995,-0.0461593,-0.052324083,-0.013952476,-0.019882744,-0.06445723,0.020968668,0.023316035,0.021071604,0.032393966,-0.016455092,0.005384317,0.019616498,-0.060666528,0.042223837,0.02343504,-0.003100785,0.085987784,0.018253727,-0.042618908,0.015423554,0.03787448,0.039537657,-0.0018732987,-0.024122166,-0.10351082,0.020063765,-0.039728157,-0.09297304,-0.02863514,-0.04123253,0.05324505,0.00038750822,-0.066429496,0.0077800006,0.02250547,0.062221408,-0.029555863,-0.07929121,0.12086245,0.020079438,0.036545232,0.03017022,0.015212331,-0.025698043,0.05929859,0.04579752,0.0025101171,-0.021822203,0.026630541,-0.04122461,-0.10534124,0.028503885,0.032684185,-0.009617982,-0.035867058,0.042716917,0.077439286,-0.04336851,0.13303949,-0.0843608,3.893514e-33,0.032697797,-0.031709883,0.034054846,-0.0861629,0.055656303,-0.037388805,-0.03139122,-0.0090324795,-0.026779912,-0.024666894,-0.037761997,-0.06868953,0.060212202,0.023435973,0.018125284,0.050927844,0.0037661127,-0.021883156,0.06928771,0.03327884,-0.034246475,0.059769318,-0.06806642,0.0012099661,0.007028658,0.022231964,-0.018648965,0.03368124,0.044757143,-0.018967621,0.068924606,-0.080245815,-0.05480114,0.0348174,0.05408634,0.0049369615,0.006302263,0.030363323,-0.016251696,0.0005560492,-0.029414983,0.06936082,-0.01784921,-0.026620658,0.053928778,-0.09306473,-0.093447894,0.048878275,0.013285673,0.06821997,0.068117775,-0.060677003,0.04011917,-0.003835534,0.014557822,0.04679959,-0.015504035,0.06782966,0.04361819,-0.004861688,0.035098758,-0.023303188,-0.041316215,-0.03519179,0.031170554,0.057183262,-0.0045898315,-0.031071918,0.0038532808,0.06477193,-0.14354965,-0.006117892,-0.01425023,0.07038164,3.7122372e-05,-0.103514336,-0.052530624,0.008580748,-0.014876264,0.010061919,0.04968988,-0.03535954,0.046692457,-0.02357359,-0.0773021,-0.014969318,-0.014043552,-0.017656589,-0.07660424,0.01119011,0.050394382,-0.019256981,-0.06157832,0.073060855,0.010391483,-4.7920302e-33,0.08051479,-0.07744945,0.070951596,-0.046668254,-0.07873752,0.06305429,-0.013009983,-0.028882109,0.011832161,-0.07428219,0.08039594,-0.0046475474,0.0407029,-0.023162246,0.01753882,0.03641951,-0.08333426,0.06452169,0.026885299,-0.03288948,-0.053157862,0.10435785,-0.05182705,0.030588254,0.055313725,-0.0015876029,-0.039042555,0.15672688,-0.0019209221,0.026004003,0.0082100155,0.011974077,-0.040055126,-0.06780946,-0.069939226,0.0015904644,-0.049688023,-0.0066053546,-0.029574117,0.019457435,-0.0109939305,0.084392585,0.06280786,0.024950573,-0.056710362,0.038489856,-0.08187233,-0.014038383,-0.015186722,0.00225989,0.022025608,-0.008726913,-0.024737412,0.039054733,0.041474782,0.12083358,0.0107691325,0.057530183,0.0139976265,-0.06910563,-0.042311132,-0.047959834,0.04468709,-0.04279927,0.06893009,0.04318354,-0.13561884,-0.0033071132,0.004714671,0.014607973,-0.02200465,0.057109013,-0.018930824,0.021565119,-0.06435861,-0.027826669,-0.109728836,-0.045786556,0.0014478801,-0.018568318,0.025789538,0.03650902,-0.025557904,-0.03758924,0.0382817,0.034941867,0.035554815,0.076937765,0.010077952,0.08779215,-0.009389416,-0.09288678,-0.041057408,-0.05304254,0.028158104,-3.4101177e-08,0.09778876,-0.017080825,-0.04065386,-0.085816935,-0.009943875,0.012581687,-0.00069591537,-0.022981606,-0.0008912718,0.011619363,-0.004507383,0.09126145,-0.052221976,0.0770207,0.01450298,-0.037838075,0.002928636,-0.002871328,-0.029138617,0.051211793,-0.056802034,0.030960768,-0.111119635,0.0749851,0.026771545,-0.033094097,0.06150954,0.026647149,0.012828496,-0.02363139,-0.005391508,0.026350185,0.020803386,-0.12772045,-0.07467602,0.039137296,-0.031967226,-0.08892249,0.00018507673,0.050116148,0.072615445,-0.049806576,-0.023875428,-0.0016501166,-0.02312573,-0.022379672,0.037475858,-0.034262713,-0.050766647,0.042852595,-0.004747041,-0.060182903,-0.07323642,-0.074844316,-0.06343365,-0.007500196,0.008655178,-0.025511947,-0.017614104,-0.037364256,0.04084012,-0.0001276208,0.18827923,-0.08921661 +2.4.1.281,This enzyme forms part of a mannan catabolic pathway in the anaerobic bacterium Bacteroides fragilis NCTC 9343.,384,1.0,-0.010619132,-0.010550771,-0.07030485,-0.048715945,0.07305905,0.0020524627,-0.070242085,-0.012520054,-0.0034711119,0.070725635,0.003855548,-0.07118309,0.021634884,0.028324135,-0.038540635,0.03636694,-0.13299519,-0.002722178,0.00053583516,0.01999751,0.07973361,0.112371705,0.03351598,0.019454414,0.0030283073,-0.054764196,0.03350376,-0.05256302,-0.07933056,-0.046416055,-0.023185577,0.030698983,0.064081304,-0.048209805,0.082039,0.094108514,0.038250837,-0.040464163,0.0983286,-0.022201242,-0.016228901,-0.0492124,0.03552079,-0.054906838,0.011210426,-0.011565274,-0.003713307,0.041172408,0.109916046,0.035845228,-0.10328737,0.014419985,0.03374393,-0.007258636,0.020608122,0.0013478202,-0.017475141,-0.09071636,-0.013433159,0.011090082,0.036216334,-0.0050177295,0.06786546,-0.025597338,0.011435558,-0.073788576,0.02656606,-0.10466954,0.044753537,-0.059517346,-0.060668617,-0.10703624,-0.031189222,-0.058588974,-0.02745066,0.031562,0.043531686,-0.060723912,-0.010931576,-0.021272378,-0.0201807,0.0092871385,0.06582096,0.053019468,-0.0169482,-0.03782898,0.04372014,-0.019343562,0.08783343,0.07332157,-0.0073434375,0.025673967,0.044238105,-0.07286528,-0.055602323,-0.040552016,-0.007365912,0.024418086,0.07149825,0.00947667,-0.016305737,0.047743708,-0.0060416306,-0.040676035,0.00086563965,-0.060493637,0.058941357,0.06911011,0.02206102,-0.061907206,0.071689144,0.0060497206,0.0050215465,-0.03144763,0.00084185146,0.06737896,-0.0030206733,-0.06631345,-0.09502236,0.057555567,0.005047177,-0.008152745,-0.016971648,0.04045339,-0.05043995,-0.03322505,-0.08238131,3.5052977e-33,0.037582494,-0.02090174,0.034335405,0.011582485,0.071264006,0.010950495,-0.11131882,-0.014728589,-0.06913227,-0.0495593,-0.10788233,-0.083679445,0.009979534,0.045607213,-0.07259439,0.009406859,-0.05005914,-0.03001154,0.0043190587,0.0048265597,0.00084288506,0.06524519,-0.0033011811,-0.035387304,0.105802245,0.027078977,0.01997111,0.03409686,0.027253151,-0.01335456,0.10244421,-0.08893008,-0.08696529,-0.055489566,0.032771293,0.010800844,-0.03801098,0.051806826,-0.04685762,0.101089835,-0.020780683,0.08055439,-0.019041283,-0.036537338,0.047535658,0.04611505,0.023254786,0.09157237,0.06077093,0.07286256,0.044750735,-0.008261659,0.07006689,-0.06837286,-0.014635965,0.020021247,-0.0006858591,0.012538064,0.029948978,0.092385516,0.040040996,-0.009887531,-0.05653387,0.025740907,0.013099187,0.008548464,0.035742316,0.016950047,0.11935342,0.036013983,-0.10032815,0.058512926,0.062405214,0.06504456,0.04634059,-0.04146904,-0.06055397,-0.05699072,-0.0065595726,-0.00045882928,-0.005611829,-0.049236137,-0.025876405,-0.021424286,-0.0702472,0.019240342,-0.08277573,-0.051637985,0.007898375,-0.028245678,0.054323923,-0.054417077,-0.11494875,0.019666893,-0.021981042,-3.952254e-33,0.14753246,-0.10845244,-0.00958982,-0.07165393,-0.09281849,0.048853654,0.039348133,0.029197048,0.023953954,0.027918454,0.09043134,-0.019999865,0.03977134,0.0072276583,-0.004897278,0.028441135,0.035709217,0.0625097,-0.055954248,0.054257773,-0.06694503,0.10415119,0.010331768,-0.07619698,0.0355715,0.05537254,-0.04594206,0.1189584,-0.0008272968,0.017787628,-0.020441178,0.010045634,-0.046059474,-0.08046368,-0.030426426,0.03090094,-0.059351634,0.04989037,-0.009752021,-0.025176449,-0.040724028,0.06480915,-0.0006652973,-0.028993947,0.005558014,0.008921092,-0.040604785,0.025218857,-0.08924655,-0.021785172,0.013000218,-0.078527644,0.06151709,-0.015947264,0.045302834,0.046332672,-0.05241288,0.043579895,0.014123408,-0.02496689,-0.0011274777,-0.035544064,0.0851765,0.024995582,0.044025414,0.056569606,-0.037377376,0.01924503,0.050985783,-0.029710807,0.01360106,0.04770839,0.05332747,0.032474477,-0.030964429,0.038017232,-0.08576888,-0.09275019,-0.0028746063,-0.04147409,0.010032392,-0.04316858,-0.0128195975,-0.05692787,-0.026501272,0.013735412,0.049078643,0.06529977,0.022871431,0.057912234,-0.041477673,-0.0077060726,-0.03767018,0.0018684024,-0.00067045796,-2.6625287e-08,0.047519308,-0.044287425,0.026284382,-0.00716785,0.052963857,0.10495408,0.0018623655,-0.013849662,0.013551581,-0.027082777,0.002240673,0.09031704,0.025109796,-0.046889417,-0.005243791,0.025190063,-0.06422208,-0.007241891,-0.025886219,-0.003409205,-0.11312947,0.013919686,-0.115693875,0.09137155,0.030740524,-0.010178441,-0.0016534392,0.02504142,0.006495477,-0.06853526,-0.011809662,0.03037983,-0.016690645,-0.0401262,-0.09517984,-0.015768778,-0.076652005,-0.06970293,0.016938657,0.033572566,0.04847655,0.0005115984,-0.028904801,-0.049378432,0.0115798125,0.0132640395,-0.051674083,0.017683294,-0.024989797,-0.0011220234,0.065254174,-0.0066122096,-0.015792478,0.06718341,-0.04944313,0.0064129876,-0.010362927,-0.070365146,-0.037188042,0.00095307565,0.01628475,-0.022316476,0.14941086,-0.095998384 +2.4.99.16,The enzyme from the bacterium Mycobacterium smegmatis is specific for maltose. It has no activity with alpha-D-glucose.,384,1.0,-0.010886178,-0.0718232,-0.06298401,0.029766249,0.023492558,0.020617798,-0.0056251767,0.05926711,-0.0004990329,0.012267949,-0.061291754,0.029902127,-0.09279086,0.043156996,-0.02871079,0.047176067,-0.0025415118,0.009391325,0.025819814,-0.0004963135,0.083604164,0.014353226,0.039124127,-0.031645004,0.059756298,-6.63277e-05,0.04256348,0.03428677,-0.046279486,-0.04529658,-0.022520313,-0.069536425,0.13157357,-0.019670175,0.12122241,0.07729323,-0.011680276,-0.01755903,0.0011946912,-0.075141124,0.045530505,-0.012443696,0.04611989,0.064456016,-0.11301496,-0.005801056,-0.13382284,0.037343964,-0.013072469,0.027741605,-0.12072213,-0.09988451,-0.02189908,0.021483958,0.023594515,0.009272182,-0.009761859,-0.020886172,-0.0002822461,-0.046281036,-0.026971428,0.045228925,0.048076153,0.018286437,0.03607528,-0.05192462,-0.022953993,-0.06399746,-0.03772137,-0.034659274,-0.045685876,-0.07580268,-0.02509107,0.07801026,0.030132096,-0.014307209,-0.020971676,-0.042771105,0.036638044,0.05644821,-0.037245978,-0.013390526,0.030026646,0.02750114,-0.0425894,-0.06653315,0.06580784,0.0037451754,0.048312943,0.03628192,-0.01838244,-0.039758172,-0.02889201,-0.08473578,0.026278019,-0.012094065,-0.034247316,-0.038770027,0.01437881,-0.038374186,-0.022286626,0.018502196,0.013182298,-0.027948016,-0.10448634,0.036158267,-0.029710138,0.041402612,0.010201551,-0.026410695,0.024519267,0.019795867,0.055874005,0.020773567,-0.05393959,0.005594997,0.037160844,-0.045128576,-0.030085256,0.027818667,-0.0153488945,-0.019942211,0.08482236,0.038298275,-0.050643783,0.10504239,-0.07890722,-1.9737107e-33,0.04701712,-0.10562657,0.0013777722,-0.0914208,-0.024962962,0.0010054361,-0.07426608,0.043575186,-0.017342322,-0.0011008099,-0.10476756,-0.05692976,0.0639511,-0.000444085,-0.03940073,0.03110525,0.048125263,-0.05473325,0.08621252,0.094234906,0.03975515,0.025535144,0.030666988,0.023737783,0.0004890164,0.068559885,-0.02713768,0.06281723,0.041260626,-0.00671348,0.05606769,-0.011586392,-0.062141586,-0.0014291331,0.037596337,0.07744316,-0.07149003,0.032222297,0.0025797565,0.06684714,0.04015918,0.027270198,0.064927876,-0.0875111,0.031081218,0.005454741,-0.022847088,0.036443565,0.040508155,0.0526897,0.018118635,-0.034215912,-0.03219364,-0.016996685,0.013830711,0.023939496,-0.0169776,0.07944786,0.0068475856,0.027224649,0.0009557762,0.06706008,0.029564483,0.017047504,-0.010800778,-0.031064473,-0.012317437,-0.0019227898,-0.05271447,0.05635305,-0.0681003,0.0022629588,0.035046563,-0.00051530905,0.00697871,-0.122377194,-0.044829782,0.012629429,0.035676666,-0.040082056,0.05281485,-0.05439375,-0.01105341,-0.030583775,-0.100392155,0.008177311,-0.13264158,-4.3159154e-05,-0.070447534,-0.012906548,-0.0217301,-0.027531441,-0.10134694,0.094819784,-0.01521767,-2.23887e-33,0.04135651,-0.11404398,0.12779815,-0.025572533,-0.017923372,0.07731863,0.07838637,-0.027011113,0.014093106,0.042840622,0.10493818,0.09367918,-0.05464552,-0.06807208,0.023355737,0.07426429,-0.048494913,0.015012372,-0.023255553,-0.010248517,-0.08901737,0.15675218,-0.020481106,-0.049797803,0.06632119,-0.0087902015,0.047660265,0.07406824,-0.0028634714,0.0036672617,0.06453809,0.057021517,-0.0064727445,-0.09625433,-0.06598158,-0.02043975,-0.061899222,-0.07182388,-0.021677209,0.0021866753,0.006706658,0.13101766,0.04989044,0.058271028,0.015560775,0.03841986,-0.08493267,-0.021442506,-0.012246112,0.015675398,-0.051652636,-0.018031081,0.023730958,-0.02571523,0.020391177,0.055228632,-0.0015648594,0.019726278,-0.092460416,-0.013191203,-0.041763037,-0.011114484,0.059115227,-0.023134602,0.050772827,0.050430473,-0.01401617,0.050791517,0.041201126,0.006717427,0.017888663,-0.022119641,-0.03917811,0.027401626,-0.03390631,-0.026465667,-0.035230484,0.06553243,0.028139846,-0.029508838,0.027701905,0.045660686,-0.014480789,-0.04010496,0.03149956,-0.05687474,-0.008027127,0.059498057,-0.0017930407,0.08254838,-0.068614155,0.029108094,0.021757247,-0.044442154,0.08190724,-2.546127e-08,0.041540958,-0.062516935,-0.02100033,0.0222342,0.018067049,-0.00091492455,-0.077530235,0.016983928,0.036884453,0.016800439,-0.06219397,0.08824147,-0.034565974,-0.011561773,0.033720624,-0.029507183,-0.0503678,-0.040107932,-0.036031716,0.048309654,-0.09197661,-0.009511908,-0.10019653,0.041969687,-0.014966276,-0.065615125,0.027145686,-0.011736593,-0.04657538,-0.004760626,-0.020923102,0.049453247,0.01925822,-0.05370382,-0.08148415,0.0040336875,-0.02204361,-0.115360595,0.017742276,0.028255813,0.12667571,-0.021263985,0.0040239557,-0.02820955,-0.07457724,0.034013204,-0.028703751,-0.049220245,-0.043792892,0.05126905,0.0017266467,0.03863803,-0.12293364,0.04883007,0.028094228,0.022528375,-0.0018696577,-0.065765254,-0.0071803792,-0.05502357,0.092521876,-0.043511804,0.10177309,-0.05799856 +2.7.1.173,The enzyme from yeast and human also has the activity of EC 2.7.1.22 (ribosylnicotinamide kinase).,384,1.0,0.008508118,-0.02842625,-0.05680853,-0.018487921,0.032896355,0.015970986,-0.058495548,0.046142694,0.047819562,0.034639917,0.04627413,-0.056151256,-0.09156984,0.031155469,-0.054336965,-0.0032705173,-0.05173309,0.007856154,0.03151073,-0.012623424,0.0032026991,0.05568757,0.023037856,0.057094797,-0.0249181,-0.01886825,0.08377055,0.049635164,-0.038352624,-0.106845886,0.047039956,-0.016647622,0.13094768,-0.030066662,-0.011076371,0.08527717,-0.01972926,-0.117088705,0.0015525963,0.057357512,0.0378841,-0.086673,0.0037729559,-0.032549042,0.020803122,0.039962083,0.024062222,0.0030939868,0.0950392,0.023037069,-0.010003463,-0.077897795,-0.0023522277,-0.021785695,-0.0052957195,0.023929654,-0.072589554,-0.015534752,0.008544985,0.024337431,0.015883004,-0.034776915,0.04585584,0.077888995,-0.003836902,-0.044640843,0.056622792,-0.060224548,-0.01580107,-0.03373433,-0.062501274,-0.1056436,0.031951945,0.08581593,0.021706196,0.01013481,-0.0002671365,-0.10548235,0.05266899,-0.06981501,0.00016862953,-0.06579239,-0.006694959,-0.02545279,-0.015974581,0.048817437,0.046996817,0.03712644,0.014559474,0.03116117,0.045372244,-0.018504757,0.064727105,-0.013016894,-0.039946258,0.053376693,-0.04175784,0.16457507,-0.024864664,-0.047301456,-0.018340105,0.09967543,-0.05107594,-0.04119626,0.024711838,0.0349454,0.031664155,0.040579397,-0.0008343731,-0.010525318,0.019574216,-0.045498572,-0.004143278,-0.008306641,0.07184093,0.09216298,0.08579183,-0.053420383,0.001203161,0.018466005,0.014373827,-0.04397892,0.04760369,0.044471793,-0.06479342,0.038592443,-0.056793816,-2.5012193e-33,0.0047053806,-0.013668139,0.05159745,-0.0132266525,-0.01659518,-0.008968797,-0.0669094,-0.025170907,-0.036654785,-0.075916424,-0.08411842,-0.040547773,0.057797648,0.042393647,-0.021740612,-0.03318073,0.040193103,-0.021325752,-0.004360175,0.021129001,0.0800237,-0.027222777,-0.026510451,0.065005496,0.039023954,0.025689464,-0.0013305272,0.015757984,0.039042905,-0.03243679,-0.046896275,-0.03706608,-0.06302818,0.07924697,-0.0072989697,-0.0045246747,0.0043367133,0.003114647,0.02844866,0.077647686,-0.017378861,-0.0054459353,0.03708847,-0.049976792,0.017321715,-0.016145045,-0.03481477,0.10065443,0.060360808,0.02340019,0.04854792,-0.03787249,0.064620554,-0.020217223,0.04934827,0.054099463,-0.08204159,0.026153,0.041654572,0.019038644,-0.055042695,0.099348344,-0.044472385,0.07996339,-0.033047732,0.03243039,-0.07730115,-0.08518007,-0.06563779,0.04711005,-0.04685297,0.011234634,0.11211399,-0.037810415,0.012142245,-0.023968535,-0.105559185,-0.019434292,-0.072247036,0.09962262,-0.051347073,-0.06873456,-0.018824626,0.0070077777,-0.039909504,0.004918164,0.025118662,-0.029035153,-0.0038503415,0.025114523,0.03471531,-0.06332545,-0.08231902,0.06003845,0.023602523,-4.4955046e-34,0.10194209,-0.046552967,0.0795281,-0.033006325,-0.05180063,0.121719785,0.05294434,-0.021469338,-0.026799921,-0.03044971,0.08839182,-0.0066274875,0.044617314,-0.10034051,0.028024882,-0.011469619,-0.07141124,0.07505907,-0.027175639,-0.004190579,-0.050053123,0.050151747,-0.04925443,0.03385362,0.08049539,-0.0017527766,0.018792102,0.042197887,-0.0100012105,-0.0358324,-0.074707195,-0.00055972015,-0.039180703,-0.037036996,0.0052251536,0.036827367,-0.070923395,-0.036278684,0.009182334,-0.052872885,-0.037085094,0.09966069,-0.056916423,0.02027461,0.007473428,0.104162835,0.017265195,0.011817237,-0.030216021,-0.08631024,-0.0044744294,0.012038052,-0.019075805,0.039404463,0.0068481257,0.04522227,-0.019921457,0.07854257,0.073823564,0.012037801,-0.010468318,-0.07533622,0.031854037,-0.0030645877,0.03549111,-0.01402036,-0.086313896,0.035491854,0.015357479,0.03522908,0.08027905,-0.014445862,-0.0052407994,0.0318582,-0.023849584,-0.02226427,-0.096786335,-0.080357485,-0.011365173,-0.06495345,-0.009037631,-0.006559756,0.013068901,-0.0019064517,-0.009752789,-0.053910483,0.032011174,0.04235897,-0.043057926,0.021167286,-0.049413748,-0.019706821,-0.11717339,0.041458715,0.014472693,-2.6666815e-08,0.044717636,0.0038906282,0.06434463,-0.10849388,0.09036115,0.019121978,0.033952456,0.08540968,0.053503927,0.0013880578,-0.06682649,0.06750419,0.074352585,0.030160116,0.048926745,0.016354876,-0.03277955,0.037907593,0.005861959,-0.016453257,0.030087387,-0.06081758,-0.08459277,0.043509655,-0.04824401,-0.057814278,0.013522614,0.109990954,-0.00794435,-0.08930608,-0.023580838,-0.030416215,0.061109174,-0.036804527,-0.022613976,0.06491255,-0.097061366,-0.03650787,-0.018625138,0.06711455,0.0018415184,-0.1002944,-0.029165296,0.016734347,-0.06910172,-0.043034222,0.07556834,0.0039728787,-0.010346525,-0.07104266,0.052410208,0.019642577,-0.04299542,-0.06621925,-0.052703764,0.024234742,-0.055337172,-0.0953092,0.047552127,-0.08945595,0.036378253,-0.056220423,0.105897024,-0.03566824 +2.7.1.174,"Requires Ca2+ or Mg2+ for activity. Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals [cf. EC 2.7.1.107, diacylglycerol kinase (ATP)], the enzyme from Saccharomyces cerevisiae utilizes CTP. The enzyme can also use dCTP, but not ATP, GTP or UTP. ",384,1.0,-0.083739415,-0.030503044,-0.04050246,-0.035065904,-0.037205104,-0.02936372,-0.023909131,0.016959317,0.070537135,-0.007512106,0.0116710495,-0.06513786,-0.091521114,0.04180822,0.007498572,-0.043722518,0.01286546,0.070207715,0.042620566,-0.03629288,0.046985045,0.03375684,-0.040738493,0.006804322,-0.015492988,-0.009488044,0.06490574,-0.0031997145,-0.018598652,-0.031342853,-0.058239073,-0.03021337,0.0071037766,-0.0616744,-0.010062631,0.10168409,-0.04330994,-0.005232946,-0.015922118,-0.042963132,0.07264063,-0.020955518,0.0031068905,0.085836835,0.031736188,0.014848879,-0.023030521,0.019255532,0.01304878,-0.0562015,-0.029261388,0.004103939,-0.007644155,-0.011327742,-0.05088006,0.04546787,-0.10683453,0.036658928,0.023223087,-0.038156856,-0.028087582,-0.010787691,0.040913697,0.019015072,0.0077263177,-0.08271537,0.008546331,-0.013328715,0.093628794,-0.016051915,-0.09758037,-0.057968922,0.034582436,0.039921265,-0.05294107,0.038261596,0.018262101,-0.061332896,0.07038059,-0.065215886,0.08946125,0.0046689073,0.023156192,0.076515034,0.08763063,0.034940302,0.04426306,0.034791406,0.010171819,0.0449074,0.05134167,0.01687826,0.03917325,0.035386357,-0.07374095,0.020542005,-0.018568147,0.011442153,-0.040450707,-0.061698858,0.05808649,0.08167531,0.045329,-0.021773003,0.037156053,0.010267787,-0.023349274,-0.0019605448,0.0061819004,0.04114114,0.042888217,0.044316396,0.014359954,-0.0456317,0.06662019,0.056647867,-0.03448106,-0.07200756,-0.0028009564,-0.0152050955,-0.07148838,-0.11532496,-0.0886917,-0.0025367336,-0.09271813,0.023887835,-0.030464472,3.3656185e-33,-0.010142974,0.027941544,-0.015582466,-0.025450276,-0.013904136,-0.053337283,-0.03632851,-0.053403545,-0.06945948,-0.10091769,-0.0015577817,-0.05735703,-0.024576655,0.11146639,-0.033022232,-0.009862423,-0.009173337,0.040348608,0.13241635,-0.036546696,-0.031944394,0.0551933,0.005273511,-0.008827485,0.08228888,0.089313775,-0.05273144,-0.015076411,0.009930538,-0.009239296,-0.0037540735,-0.07966551,-0.022894233,0.11491887,0.057785273,0.058044974,-0.008300476,-0.03561695,0.010372516,0.06093726,-0.06363234,0.02384788,0.013977103,0.012198838,0.004416768,-0.024261784,-0.10475393,0.07621916,0.029315434,0.03380523,0.058801197,0.0064362017,0.039674383,0.0147700915,0.015209299,-0.019154485,-0.036135834,0.04316513,0.018017752,-0.0032405516,-0.0007609444,0.0742579,-0.088416226,0.04851382,0.03449361,0.06210127,-0.12949668,-0.09805381,-0.0014408882,0.035178162,-0.0035437834,-0.0054278653,0.08658767,0.010810392,0.051876638,0.006118765,-0.003378893,0.032728296,-0.05518602,0.11028738,0.014016419,-0.057843998,-0.018590314,-0.016249796,-0.05548486,0.02670231,0.020340966,0.01870092,-0.00042777334,-0.008182469,-0.017317168,0.016862951,0.033986613,0.104382,0.01499216,-4.357168e-33,0.06330506,0.0077182017,0.094303966,-0.06274984,-0.06712543,0.050912406,-0.005046995,-0.17022656,0.07665109,-0.03423049,0.02513784,-0.041112445,0.024814062,-0.009819255,-0.026649086,-0.010579758,-0.07155671,0.05145194,-0.070149444,-0.038493637,-0.0037299222,0.12262321,-0.044532854,0.13375193,0.062058195,-0.014517555,-0.061891176,0.024069536,-0.0025986244,0.009867966,0.0030663102,0.024724767,-0.043094892,-0.02488982,-0.058521613,0.00987372,-0.06491188,0.07053037,-0.021161923,0.05080872,0.019540764,0.046559397,-0.0076533994,0.015676908,-0.025600463,0.05799666,0.050350904,0.007877162,0.0075895716,-0.051274523,0.018188914,0.032500062,-0.05296151,0.047877993,0.040384077,0.1143706,0.025110714,0.058176387,0.034928758,-0.07891969,-0.06829358,-0.0828321,0.04169648,-0.07399961,0.051285814,0.07228184,-0.03507846,-0.008416674,-0.013281423,0.035974067,0.028379932,0.107767574,0.029048417,-0.014213318,-0.070103265,0.037003156,-0.051176615,-0.056931175,0.0005194205,-0.050999936,0.010336641,0.047755107,0.032847192,-0.0267035,-0.04918167,0.01922193,-0.05171685,-0.028293367,-0.011452746,0.035483018,0.014796525,-0.06813539,-0.05954491,0.042601068,0.007792217,-3.9439545e-08,0.04818311,0.01950259,-0.012790497,-0.10617919,-0.0097119175,0.063851014,0.06811077,0.023837557,0.07945569,0.0042926334,-0.035376985,0.07322168,0.020115525,0.016886672,0.058632232,0.031804293,-0.0037824535,0.047612663,4.2607546e-05,-0.08089718,-0.0015901949,-0.053329628,-0.12799256,0.12485266,-0.00056097686,-0.056042146,0.026078349,0.011978774,-0.006975302,0.0030850966,-0.018532934,-0.0008959546,-0.018679414,-0.016941937,0.028504096,0.054845497,-0.056246627,-0.07669059,-0.086335,0.05679118,-0.0030229862,-0.018896785,-0.023947652,0.031182263,-0.04761965,-0.038478322,0.07008687,-0.046346776,-0.053112715,-0.0024889898,0.015226262,0.0049582836,-0.01531757,-0.10939502,-0.079713255,0.025404695,-0.032165416,-0.03822558,-0.079528145,-0.061133124,-0.00224925,-0.00801102,0.18602183,-0.06899361 +2.7.1.175,Requires Mg2+ for activity.,384,1.0,-0.060790077,-0.05960818,0.06589377,0.025950506,0.018331017,-0.079263404,0.061365385,0.015990194,-0.06144127,0.03116765,-0.007677045,0.016300902,0.018964745,0.047117166,0.09703121,-0.0022578633,0.07970149,0.05329479,0.02340152,0.03721413,0.09611903,-0.034432918,0.06627953,0.0071463482,-0.023372581,0.057631455,-0.019427558,-0.014400437,0.07025708,-0.0104233995,0.009573419,0.054991324,0.08037698,-0.059439946,-0.04362916,0.067596085,-0.0136954505,0.0075166733,-0.092280746,-0.07094738,-0.0149473315,-0.046715602,0.07469269,-0.0059906486,0.040474005,-0.09520747,0.061074156,-0.106486775,0.059206817,0.0668154,-0.023336597,-0.0387117,-0.046784703,0.026113793,0.026994562,0.01564008,-0.11781437,0.022217566,-0.0062410235,0.022554787,-0.04108908,-0.026231876,-0.053445384,0.026524452,0.06058778,0.06590911,0.0454534,-0.07451168,0.022208873,0.00017079707,-0.012213516,-0.031215033,-0.008536567,-0.021984685,-0.06149867,0.013690624,0.034637626,-0.09154157,0.06656534,0.0037888254,-0.03434827,-0.016332863,0.03747744,0.080097,0.062395312,0.025384326,0.030066242,0.010601766,-0.031048525,0.05969741,0.06153535,0.052400324,0.029620638,0.06294733,-0.013354378,0.002077971,-0.11711153,0.0039812094,-0.06477191,0.050145395,-0.028145898,0.049771123,-0.037076335,0.05172549,-0.036933098,-0.025267024,0.02390069,-0.032861453,-0.012979366,0.07779052,0.06427688,-0.034115884,0.030582765,0.041521266,-0.0062323306,0.07245949,-0.03959666,-0.048715375,0.004187488,0.028155038,0.018543465,-0.030824356,-0.012990507,-0.022339359,-0.050811328,-0.03165901,0.03027758,-2.0637453e-33,-0.0053508016,-0.0197835,0.071408,0.050433725,-0.063727655,0.040408738,-0.07832165,-0.0417292,0.037224203,-0.048125207,-0.07391685,-0.005648808,-0.045858886,0.10248045,0.05842552,-0.08516803,0.05751184,0.012287835,0.13700674,0.015277692,0.02997533,-0.021483501,-0.010012857,-0.026880657,0.009206558,0.17837198,0.082225494,-0.06813276,0.07635362,0.027991062,0.012448565,-0.11149579,-0.030480294,0.022800315,0.01646083,0.06308423,-0.052112512,-0.046288136,-0.0008042059,-0.018704228,-0.06508811,0.045802448,-0.07584181,-0.006930916,0.04689446,-0.09165215,0.057161096,0.012002658,-0.033102963,0.055371538,0.0642887,0.03727322,-0.02156047,0.023536824,-0.043999173,0.044765215,0.013470396,0.034324728,0.08825868,0.07401302,0.0076112263,0.013177398,0.09110007,0.047731705,0.03911454,0.054985527,-0.09773124,-0.048735965,-0.046318498,0.02406073,-0.0055457745,-0.05691338,0.092528395,0.03324215,0.028597841,0.0009887328,-0.008272652,-0.030911312,-0.005269611,0.016616536,-0.060429107,-0.092700906,-0.0004873265,0.020429714,-0.06318938,-0.023279816,-0.007002953,-0.06362018,-0.0394266,-0.008020647,0.010152225,-0.039577264,-0.054881472,0.04639239,-0.022701195,1.483864e-33,-0.04912281,-0.0214795,-0.008231579,-0.010753594,-0.023654386,0.033242058,0.022361038,-0.14278644,0.032284737,0.07845521,0.03712812,0.031232292,-0.045562953,-0.062041976,0.051909804,-0.055861853,-0.032928433,0.038101777,-0.013590829,-0.008670128,0.033317678,0.12016287,0.022404645,0.041800823,0.03337177,0.05347675,0.015493491,-0.0019724788,0.0414988,0.037192315,0.047791217,0.08024261,-0.10704589,-0.082046896,-0.04802206,0.030799506,0.021402523,0.009556856,-0.093700975,-0.013893651,0.0343629,0.07431838,0.05944028,0.10196152,-0.008598897,0.023211202,0.055077255,-0.004433255,0.016091647,-0.021730807,0.023474373,-0.04812101,-0.07550035,-0.078594,0.04172412,-0.008541541,-0.033007704,-0.061791506,-0.017096959,-0.075885035,0.06992493,-0.029262861,-0.021871684,-0.086994685,-0.005904143,0.044553824,0.04126407,0.061756372,0.0011206452,0.06849599,0.02756689,0.039894782,0.08222994,-0.034087125,-0.036098007,0.0973054,-0.024729343,-0.044662625,0.051950186,-0.14311704,-0.04167455,-0.0014784962,-0.011616141,-0.06057205,-0.0028408398,-0.116224,-0.043837365,0.04181758,-0.0118485,0.023558624,-0.049966738,-0.019522585,-0.014123883,0.08152368,-0.049955036,-1.5596209e-08,-0.032438,0.008350817,0.06394643,-0.011276234,0.002076065,0.03788979,-0.017993338,-0.0023198614,0.07000531,0.03785883,0.05812419,-0.03889634,0.0116652595,0.008817594,0.035463385,0.022386644,0.007971011,0.01745687,-0.10230079,-0.06774167,-0.055057954,-0.08878699,-0.061989997,0.017453242,-0.007650655,-0.06793563,-0.008166877,0.055408172,0.035667818,0.018378478,0.027859949,-0.025465064,0.022290692,-0.007056007,-0.03179426,0.022648748,0.030921517,0.023490686,-0.039901372,-0.05900549,-0.0977618,-0.041318357,0.098855495,0.010589146,-0.0881415,0.0013632965,-0.054603256,-0.047250886,-0.04033571,0.0069687944,0.05462693,-0.03198077,-0.034533396,-0.018924005,-0.013385598,0.07012223,0.04762606,-0.04565856,0.007486575,-0.091579534,0.0321474,-0.034122285,-0.051311363,-0.031446107 +2.7.1.176,"Toxic component of a toxin-antitoxin (TA) module. The phosphorylation of UDP-N-acetyl-D-glucosamine results in the inhibition of EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, the first committed step in cell wall synthesis, which is then blocked. The activity of this enzyme is inhibited when the enzyme binds to the cognate epsilon antitoxin.",384,1.0,-0.031413216,-0.03542419,-0.03949864,0.019342063,0.033236593,-0.016156798,-0.01776651,0.054298557,0.041521944,-0.017460326,0.036326483,-0.0007506317,0.04124833,0.05157165,-0.10931388,-0.010948696,0.010555568,0.016617589,0.061778415,-0.029207176,0.019057918,0.05198317,-0.036630392,0.004132679,0.012162328,-0.047695994,0.038200676,0.043809645,-0.013723718,-0.10732149,-0.042230338,-0.093880765,-0.06012129,-0.020301405,0.07194358,0.05612967,-0.049980734,0.0010174259,0.07700484,-0.06741345,-0.0118209245,0.0035135036,-0.062828735,-0.0014770722,0.038537107,-0.027924767,-0.020912526,-0.026203375,0.03496831,-0.017517813,0.065674655,0.0049174847,0.020778853,0.076549515,0.062202435,-0.0056767194,-0.10299303,0.056663703,-0.017157633,0.041602593,0.011963551,0.048357613,0.026913034,-0.064748466,0.09445865,-0.0019499208,0.038339928,-0.03569762,-0.025098655,0.039423294,-0.0027664176,-0.0729737,0.023752822,0.01202363,0.03814991,-0.005543263,-0.09678676,0.036474373,0.0625869,-0.03396583,0.06839584,0.04195545,0.06859783,0.1162378,-0.00037179716,0.04858077,-0.014520785,0.014255387,0.004482559,0.054061707,0.06939772,-0.006508284,0.03460364,0.025974391,-0.0131664695,-0.03994871,-0.013628279,0.0864713,-0.040882394,-0.03212382,-0.0010956264,0.05896339,-0.114240006,0.011893449,0.06478553,-0.019869212,0.017900828,0.03801979,5.570745e-07,-0.03580845,-0.025509788,0.005905979,-0.014898274,-0.004931719,-0.08036162,0.06981489,0.039671116,-0.022451576,0.004082463,-0.021243926,0.07576241,-0.03396598,-0.013045104,0.07093583,-0.028450267,-0.009098175,-0.0059955544,1.803301e-33,0.014188819,0.016523981,-0.026501289,0.011549797,0.02979962,-0.046158627,-0.050882306,-0.03506201,-0.002971864,-0.025796164,-0.12119416,-0.0923809,-0.010603115,0.10648383,0.018552748,-0.0037455694,-0.06960099,-0.08225837,0.041821852,-0.09406974,0.015958339,-0.035659518,-0.031612262,0.03866469,-0.050899092,0.08199707,-0.09314725,0.053251095,-0.0031023694,0.030195214,-0.07008536,-0.07716438,-0.036236484,0.056592178,-0.014563609,-0.017135605,-0.0050603296,-0.044350732,0.01036602,0.026234973,-0.00066136965,-0.00592635,-0.028040668,-0.06598041,0.0397087,0.0057620215,-0.079342216,0.02208736,-0.008993467,0.029952846,0.06898744,-0.05947043,0.025016805,-0.05868773,-0.052152116,0.01509598,-0.042198386,-0.116994455,-0.00679964,0.09679879,0.019328069,-0.0021491388,-0.040367384,0.023276886,-0.03992505,0.04628766,-0.0750815,-0.11490632,0.020850051,-0.024826566,-0.061128646,-0.0313512,0.050453987,0.034996748,-0.013297217,-0.0027194996,-0.03996773,0.06300247,-0.010596929,0.003408883,-0.020300793,-0.03177877,0.0052785776,0.021309527,0.034191627,0.012038926,0.026979577,-0.070655465,0.021812031,0.065729514,0.012633828,-0.042480838,-0.029997177,0.06544063,-0.07051168,-3.0208539e-33,0.10201259,-0.01999476,0.08056493,-0.043687742,-0.06298967,0.033116993,-0.0055999723,0.0062291673,0.122444704,0.07036897,0.0387872,-0.020762663,-0.038569305,0.06891989,0.05413818,-0.02759535,-0.031044085,0.06188223,-0.017725088,-0.0035118237,-0.021647338,-0.001920231,-0.022524655,0.09560046,0.03518499,0.014525034,-0.036061533,0.023787096,0.05091976,0.055273596,-0.008598166,0.053387627,0.017935088,0.045965493,0.028662222,0.037829507,0.045553148,0.006618083,-0.067452446,-0.029319275,0.03637382,0.049420934,-0.09108034,-0.03749715,0.056352563,0.03969204,-0.05147898,0.009440481,-0.051598355,-0.06877958,0.09392462,0.08600704,0.06887139,0.03371448,-0.016028112,0.05411931,0.080180496,0.027350238,0.08797975,0.065752804,-0.00067008415,-0.041244943,-0.033022527,-0.04957764,0.11165864,0.008799717,-0.018749598,0.09183351,0.034311343,-0.02985978,0.034042254,-0.017438712,0.02368031,0.0087903235,-0.10485425,-0.06066294,-0.079905055,-0.028056795,0.08874459,-0.020032495,-0.017834025,0.02708707,0.014583929,0.008537398,-0.01729778,-0.02866939,0.027944513,0.15113127,-0.01251718,-0.0005069195,0.009708061,-0.064421736,-0.07836507,0.0064149215,0.026888406,-4.596216e-08,0.05704426,0.0076652877,-0.020091271,-0.081260435,0.004241695,0.041717995,0.011200089,0.014447005,0.07225467,-0.022977844,-0.014381102,0.0941713,-0.046918627,-0.035351593,-0.11946821,0.0751254,-0.07369963,0.045991134,0.014637091,0.035286598,-0.058264643,-0.009833408,-0.10374632,-0.013150213,0.019135581,-0.10855368,0.045675714,0.0893993,0.016696531,-0.04538689,0.0010089596,-0.007871008,-0.010050268,-0.04205691,-0.11780523,0.04082679,-0.03523425,-0.089014985,0.048833054,0.08409377,-0.046830293,-0.026535556,0.0020934264,-0.04185939,0.026369745,-0.0056842705,0.0125813475,-0.069382854,-0.0683196,0.00097108923,0.06247846,-0.0308288,-0.0408071,-0.08739335,-0.08046857,-0.07302895,-0.02985056,-0.04952067,0.008173746,-0.09582077,-0.005236958,0.061451476,0.18046583,-0.015724821 +3.1.3.87,"The enzyme participates in the methionine salvage pathway in Bacillus subtilis [2]. In some species a single bifunctional enzyme, EC 3.1.3.77, acireductone synthase, catalyses both this reaction and EC 5.3.2.5, 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [1].",384,1.0,-0.10045045,-0.04263522,-0.015714351,0.012010682,-0.009063672,0.025099348,-0.113630794,0.053283066,0.011480976,-0.022784887,0.015221936,-0.14462614,0.0274755,0.030066391,-0.04574973,0.062281743,-0.07458012,0.00578121,-0.03177516,-0.08341908,0.062003847,0.089981794,-0.07246748,-0.038040843,0.06690912,-0.06811876,0.048411172,-0.043563735,-0.025719643,-0.06958639,-0.06003814,-0.039512202,0.044200312,-0.032712024,0.06386271,0.12999554,-0.025271615,-0.009463035,0.14904018,-0.014630611,0.059174143,-0.000808581,-0.03284438,-0.053597003,0.0004785895,0.015655736,0.0014332784,0.0061610728,0.054262586,-0.046599578,-0.09153137,0.021328278,-0.0132079935,0.00091906847,0.0640849,-0.016468046,0.029677164,-0.017599806,-0.009323261,0.012156056,0.059792154,-0.057377376,0.0074861203,-0.05938441,0.05040126,-0.08156258,0.023848435,-0.06750288,0.038830496,-0.030724466,-0.054707922,-0.032407723,-0.00029229152,-0.011347391,0.019195482,-0.0015700243,-0.0607001,-0.02404632,0.020159613,-0.06612729,0.05930382,-0.0149670215,0.022011342,0.05394961,0.09029888,-0.01345458,0.025165306,-0.034601122,0.073652096,0.024992473,-0.050651684,-0.04513786,-0.03728861,-0.07580431,-0.007802688,0.0064699324,-0.07078902,0.06535664,-0.01454686,0.014205374,-0.037016314,0.061849155,-0.053280834,-0.034092654,-0.097383395,-0.05072404,0.117932074,0.077170454,0.037789386,0.031332303,0.03616101,-0.04944217,0.08245397,-0.025947105,-0.037243772,0.089737825,-9.209477e-05,-0.02135421,-0.016962754,-0.044973828,0.020557925,-0.022417216,0.082304195,0.008064088,-0.04880356,-0.009222562,-0.037978474,1.7517593e-33,0.06548263,0.041718256,0.010724484,0.028072568,0.02722191,-0.032497548,-0.119046986,0.022412382,-0.06902261,-0.093111776,-0.031670004,-0.047792967,0.01733044,0.067416675,-0.06495877,-0.022767082,0.014818273,0.00041873966,-0.022639222,-0.044042163,0.0013968493,-0.023149801,-0.028483681,0.03245666,-0.017447095,-0.02825352,0.048806917,0.018484894,0.03503935,-0.022739502,0.007148362,-0.010023572,-0.06630914,0.049141943,0.014323321,0.03280438,-0.05745902,0.014035161,-0.013850355,0.06680682,0.010357128,0.051158663,0.00010400884,-0.07023012,0.016923053,-0.033203095,-0.0881577,0.1138847,0.055462897,0.07607771,0.02319608,-0.003682266,0.12218064,-0.06146709,-0.04610176,0.012738617,0.02978846,-0.02995204,0.03574946,0.065515794,-0.025738845,0.018880667,-0.02443861,0.034759726,-0.052221544,0.03907086,-0.055919282,-0.008232981,0.038787175,0.021429807,-0.03811424,0.03060901,0.028270265,0.025524126,-0.057548203,-0.019957442,-0.056696378,-0.024230389,-0.025738034,0.030073956,0.074620046,-0.056942344,0.012803717,-0.04983808,-0.035351433,0.015217562,-0.04232984,-0.07730664,0.044233948,0.050187625,0.0147150345,-0.064724006,-0.048196442,0.083636574,0.044937342,-1.4937517e-33,0.11293838,-0.043162424,0.05767753,-0.094625555,-0.09910384,0.029493988,0.017805252,-0.0032826134,0.042574883,0.047454767,0.07675023,0.015751693,0.07755769,-0.033822328,0.022024525,0.014141294,0.057760764,0.08521285,0.066505365,-0.0040131374,0.07046888,0.07625638,-0.0051194485,-0.015866771,0.0825886,0.08056974,-0.0066029807,0.11368358,0.0008372674,-0.025018804,-0.045068316,-0.050020855,0.0041199573,0.004389839,-0.063140295,0.07131492,-0.008890614,-0.04105867,0.021229947,0.015700819,-0.04479006,0.09494144,0.0009338489,0.07901561,0.07502102,0.061140727,0.012928012,-0.0012108374,-0.017398128,-0.12617329,0.06795789,-0.0258074,0.014887421,-0.08221172,-0.0069203633,0.07550445,-0.030824373,0.0834276,-0.03793968,-0.09520409,-0.014730278,-0.00785649,0.061308227,0.011917495,0.014662619,0.07863599,0.009263076,0.043179758,0.035929687,-0.03850447,-0.0036939464,-0.018462695,0.03567061,-0.007357133,-0.024342053,-0.0073561273,-0.09679059,0.027322933,-0.0032816886,-0.019815283,-0.038452856,-0.04137009,-0.07299933,-0.034411684,-0.051363036,-0.032484744,0.026993752,0.08158582,0.028095974,0.039846864,-0.13300265,0.04562224,0.022478303,0.06929027,0.0710511,-4.0369812e-08,0.13062873,-0.10068409,-0.007704488,0.0038535364,0.03315855,-0.024881035,-0.005864633,-0.027760321,0.08716945,-0.016275194,-0.07243704,0.023916619,-0.014556585,0.021956194,0.0077461516,0.02385644,0.015063298,0.018840805,-0.027358899,-0.02336289,-0.03210281,0.016279131,-0.045617882,0.05942837,-0.010168536,-0.07285217,0.013972631,0.00975476,-0.080753304,-0.05814931,-0.010992503,0.02942117,-0.0049865744,-0.041018978,-0.072395496,0.021888265,-0.0924461,0.002601211,-0.0058414517,-0.00044687628,0.06326773,0.03460443,-0.036367998,0.033543035,-0.020767888,0.024366975,-0.02785297,0.017212806,-0.01920461,-0.04019112,0.01921062,0.024034709,0.07068979,-0.020697746,-0.113937095,0.04437715,0.0017152291,-0.020092184,0.0066993483,0.017630754,-0.01669177,0.011133684,0.15972967,-0.06454673 +3.1.7.11,Isolated from Ocimum basilicum (basil) and Cinnamomum tenuipile (camphor tree). Requires Mg2+ or Mn2+. Geraniol is labelled when formed in the presence of [18O]H2O. Thus mechanism involves a geranyl cation [1]. Neryl diphosphate is hydrolysed more slowly. May be the same as EC 3.1.7.3 monoterpenyl-diphosphatase.,384,0.99999994,-0.063457645,-0.0053427736,-0.05460625,-0.041972704,0.081056155,-0.01753043,-0.020997355,0.026348906,0.019984715,-0.06218851,0.10844084,-0.058492314,0.027528286,-0.0027945864,-0.06324264,-0.01848578,-0.0075643877,0.03115284,-0.0089046955,-0.0321473,0.030616641,0.037649836,0.0038388676,-0.025558311,0.06571656,0.023132721,-0.01355261,-0.04101523,0.0612571,-0.059010394,0.004209373,0.043935582,0.008963718,-0.10317654,-0.009801712,0.05012491,-0.05870652,-0.040904548,0.016183103,0.045371518,0.038077213,0.011717798,0.021981688,-0.08438221,-0.03346528,-0.018705627,0.01789193,0.00868845,-0.006202647,-0.035265356,-0.080827996,-0.047004268,-0.015123941,0.034570344,-0.019403085,-0.02806374,-0.05522856,-0.017406438,-0.082466915,0.09087779,-0.020768695,0.010093771,-0.053778972,-0.04998791,-0.010261535,0.0651966,-0.02674756,-0.048358466,0.09311817,-0.021416321,-0.0036422426,-0.06814104,0.044981945,-0.08644867,-0.067429,0.039273627,0.048491977,0.009452344,0.067924105,-0.04784504,-0.026803264,0.056300502,0.04598588,0.014674483,0.05447311,0.046514947,0.0040610987,0.09979866,0.042060506,0.087787986,0.015508878,0.053763,-0.07680068,-0.031684022,-0.06278844,0.08577161,0.00576701,0.036173962,-0.036218822,0.040607788,0.047332745,0.07240428,-0.043961998,-0.07711825,-0.0699438,0.01889417,0.03798218,0.0008366356,-0.007015515,0.000108510234,0.012200411,-0.025580408,-0.023450729,-0.013725002,-0.09745889,0.02737204,0.06399226,-0.08421054,-0.03745711,0.03483246,0.028885782,-0.04268194,-0.027687132,-0.0031262883,-0.054951843,0.081997104,-0.04316523,5.4663235e-33,0.059597623,-0.026593007,0.03894392,0.011013841,-0.057328813,0.08883601,-0.11118298,0.022968441,-0.06612902,-0.08506108,-0.015859356,-0.066377826,-0.03731888,0.0014887194,-0.020703232,-0.082737945,0.009005809,0.017394671,0.12161331,-0.07208023,0.03199887,0.09043699,-0.09995928,-0.057366643,0.015415991,0.04365057,-0.061090227,-0.06844443,0.02275816,0.022474118,0.04261919,-0.10565813,-0.04344213,0.05254943,-0.014884234,0.00788202,-0.09710199,-0.06309095,-0.03147382,-0.009406043,0.010764419,0.066402525,0.021014005,-0.019014819,0.02281875,-0.06258021,-0.03716618,0.05712689,0.078387596,0.03125091,0.017691465,0.047783203,0.06052964,0.057922047,-0.055999953,0.013427296,-0.011613239,0.04627241,0.05736151,0.02839824,-0.031734753,0.04652285,-0.050011724,-0.007741626,0.117689244,0.078503594,-0.11753405,-0.0036074151,-0.026330683,0.057532128,0.0029511377,-0.06747787,0.013956889,0.056935586,-0.048109256,-0.011011682,0.014464019,-0.041513253,-0.030122006,0.066133685,0.028995428,0.0006062253,0.028026644,0.00028710582,-0.08802595,0.051585317,0.020039793,0.05002159,0.024954615,0.035846483,0.04070756,-0.017984118,-0.054549247,0.012201065,0.014703956,-4.3925594e-33,0.07147701,-0.06530004,0.039206427,-0.10919737,-0.09375218,0.06267261,-0.019595398,-0.045785457,0.012510823,0.057926275,-0.023890033,0.017873345,0.10472234,-0.06491528,-0.0720688,-0.0076994556,0.07536401,0.09917693,0.05358191,-0.008107287,-0.0045832302,0.14100933,0.038125813,0.037199378,-0.0036088224,0.02101664,0.07824904,0.012863684,-0.030665884,0.0720587,-0.014501603,-0.004926317,-0.05485922,-0.047837786,-0.019198935,0.020042425,-0.07081963,-0.047627404,0.016775943,0.02984604,-0.062208466,0.05102227,0.12127137,0.052910168,0.050681625,0.05441968,-0.057895288,0.037490916,-0.03782463,-0.020475645,-0.005820036,0.005328808,-0.06711789,0.003856889,0.039285894,-0.064749785,-0.015658852,-0.023416644,0.02162959,-0.11512868,0.041964788,0.007604016,-0.11492209,-0.058974676,0.03540226,0.07508707,0.0025835996,0.058994263,-0.008765734,0.012770021,0.036049288,0.07146515,0.09206025,-0.0042776475,-0.0006219507,0.04462435,0.021476569,-0.027013747,0.017061252,-0.13791518,0.08139381,-0.012934628,-0.011586033,-0.06625962,-0.013022655,-0.048310883,-0.023745937,0.06900398,0.055163387,0.0238209,-0.033971198,0.027495138,-0.07321187,0.11145812,0.09903405,-4.0423867e-08,0.0065191975,-0.09481047,0.0515222,0.00866485,-0.059166793,0.018483344,0.029997503,-0.031119896,0.06723834,0.012877979,0.04177606,-0.014429896,0.011942222,-0.01568016,0.021814367,-0.0023996015,0.045466267,0.07592042,-0.050182957,-0.024651552,-0.018634377,-0.016312296,0.019838732,0.030125415,-0.0016720805,-0.05327097,0.04907706,0.02723366,-0.0022413793,-0.062753886,0.0049091903,0.012863292,-0.003505372,-0.018771874,-0.024229582,0.0903597,-0.04084637,0.023393484,-0.048743363,-0.038620155,-0.04936486,-0.057260945,-0.0019741857,0.009397157,-0.080304846,-0.011864993,-0.0060289265,0.034073874,0.030236777,-0.026864782,0.050029855,-0.028469482,0.10438426,-0.025553958,-0.09513441,-0.06455417,0.0072019193,-0.008561972,0.03178268,-0.061734304,0.0017577801,0.04250622,0.090687126,0.06807441 +3.5.1.110,The enzyme participates in the Rut pyrimidine catabolic pathway.,384,0.99999994,0.012134094,-0.060317576,-0.105973415,-0.019817898,0.05612928,0.046250124,-0.023162672,0.06062395,0.018340822,-0.022521004,9.0546186e-05,0.029275866,-0.06159957,0.057756662,0.038847722,-0.006004575,-0.107770726,-0.005071523,0.012477716,-0.080762416,0.020387439,-0.023021601,0.0379034,0.015828831,-0.02349452,0.009322409,0.09038176,-0.04096607,-0.027187966,-0.04309193,-0.01902309,-0.1735313,0.047353894,0.0038600347,0.058533207,0.08019743,-0.06135979,-0.016268138,0.01021188,0.08047311,0.04304698,-0.017218865,-0.06361768,0.004225198,-0.01691658,0.0037457845,0.049635813,-0.029368507,-0.0033224719,0.012048723,-0.047710672,-0.020983135,-0.05022475,-0.013145173,0.07217687,0.05342815,-0.015079917,0.016412113,-0.03667614,-0.018677793,0.025713593,0.013913896,-0.00491901,-0.041254308,0.023182133,-0.018748676,0.056176923,-0.009991188,0.040332098,-0.0579666,-0.004256899,-0.07106092,-0.077899024,0.048560496,-0.013700112,-0.055462193,-0.009802061,0.0045092413,-0.034210972,-0.00217933,-0.000114928036,-0.03622703,0.04403578,0.02757708,0.031851545,0.0576966,0.00058669486,-0.0033512744,0.036047455,0.0113071315,0.010870358,-0.05615601,-0.048558332,-0.0023068138,-0.10173515,0.010580123,-0.05224172,0.0011567435,-0.019946808,-0.047854763,0.017387334,0.011855459,-0.09644177,0.014788148,-0.024884071,-0.045459796,-0.018912913,0.026744,-0.050946664,-0.017919356,0.036431592,0.08163599,0.08693308,0.05015672,-0.013198221,0.08420523,0.007987874,0.0012914792,-0.06692551,0.0905477,0.024226334,0.06529623,0.016905406,0.110942654,-0.054685608,-0.02757704,-0.07627985,9.898181e-34,0.016240632,0.025985826,-0.0009548622,0.0019511555,0.014180849,0.061909452,-0.08961316,-0.008369261,-0.071966864,-0.065850616,-0.0146146165,-0.09752053,0.08469191,0.024833411,-0.05284374,-0.00036094367,-0.05487192,0.018067036,0.031015426,-0.04600579,0.02682709,0.02433669,0.010536776,0.0024595086,-0.029687848,0.04426758,-0.009510536,0.060578033,0.04222265,-0.03130091,-0.02543521,-0.1017275,-0.038945794,0.045651004,0.021452568,0.0063427165,-0.012954115,-0.06166054,-0.010024766,0.052268956,-0.05231909,-0.026431141,-0.033157192,-0.006639829,0.04779053,-0.043930344,-0.0072575393,0.14570194,0.06202044,0.08921766,0.03617263,-0.078446314,0.08532224,0.026979646,-0.04268067,0.039873436,-0.027647076,-0.04461512,0.017137265,0.07986341,0.095311,-0.0016637717,0.0025259943,0.012897777,0.08139332,0.019926269,-0.0077348603,-0.050328996,0.07499278,0.08601976,-0.073914684,-0.009211462,0.09652785,0.014975041,-0.0066795177,-0.030713871,-0.067391954,0.08612733,-0.002822207,-0.0017225383,-0.076520786,-0.04301853,0.038095966,0.0114120245,-0.06532189,-0.030685706,0.01510629,-0.0852787,-0.015621891,0.01485798,0.062383525,-0.046613578,-0.08251449,0.020398065,0.02782114,-6.7727085e-34,0.14940988,-0.083072096,0.009177206,-0.07384482,-0.040282756,-0.020201545,0.09146811,-0.014727412,0.0075419815,0.018796673,0.05891106,-0.030194815,-0.024026379,-0.027174916,-0.010967768,-0.018322384,0.035715804,0.055679686,0.03776335,0.003343865,-0.05871134,0.044028275,-0.03433267,0.0818201,0.011254279,0.014004013,0.060003806,0.015660888,-0.017661462,-0.046071738,0.020793233,0.0007345778,-0.11650359,-0.06721244,-0.006389425,0.07479003,-0.07356097,0.015873631,-0.03756178,-0.060295984,-0.0021140955,0.063319795,-0.02441134,0.010404183,0.01860941,0.04771267,-0.005791765,0.033359706,-0.016114201,-0.07092811,0.045129575,-0.0387147,0.060960524,0.03328901,0.041041926,-0.043928508,-0.04560423,0.009658174,0.008716654,0.0094881505,-0.01720601,-0.01978227,0.039702956,0.056153227,-0.0067288177,-0.046467114,-0.03613174,-0.00040673628,0.054507468,0.047084246,0.057279885,0.0066334396,0.070810206,0.06557593,-0.14834872,-0.009037647,-0.033789184,0.036162086,0.06895569,-0.025878156,-0.008883031,0.0032057303,-0.011026685,-0.08246277,-0.008613729,-0.05754814,-0.04994413,0.08717151,0.1064679,-0.010437873,0.016087757,-0.05890643,0.030627087,0.01307841,0.08549971,-2.0559375e-08,0.027502695,-0.052688792,-0.049063846,-0.00812232,0.016524844,0.02982003,0.032119654,-0.00806208,-0.05987304,0.010486214,-0.015928937,-0.024248684,0.019008849,-0.03670112,0.018262139,0.11676936,-0.008470075,0.076717526,0.03302474,-0.0016287134,-0.08282364,0.012446484,-0.15041271,0.028452393,0.102874406,0.017674794,-0.008790411,0.0684827,0.040084027,-0.03446036,0.11022625,-0.10432752,0.09964621,-0.024261909,-0.006227672,0.045990482,-0.0035749255,0.0683558,0.032447536,-0.0029758944,-0.049448047,-0.04637478,0.029335327,-0.016161852,-0.03831237,0.08659132,-0.092533164,0.022018977,0.013552957,0.010251065,0.08342861,-0.0286286,0.02045103,-0.04776116,-0.13525456,0.027024621,-0.021025926,-0.1004805,-0.030139536,-0.033856075,0.037215974,0.036733586,0.1553289,0.010726147 +3.5.1.135,"The enzyme from the bacterium Escherichia coli is one of the smallest known monomeric amidohydrolases (103-amino acids). The enzyme is active towards a wide range of N4-acylcytosines/cytidines, but is by far most active against N4-acetylcytidine.",384,1.0,0.0027487206,-0.078765936,-0.091249585,-0.037629057,-0.0075953733,0.04892008,-0.09131407,0.086098626,0.06609919,-0.031331424,0.018477254,-0.050088625,-0.006503859,0.097197145,-0.06959141,0.026722841,-0.011239706,-0.034125432,-0.018834567,-0.121667005,-0.014336468,0.034765366,0.011969058,-0.038446844,0.0016466159,-0.02843438,0.019123733,-0.03616276,-0.021917885,-0.063064106,-0.006466298,-0.04611028,0.098872475,-0.0032563473,0.12989861,0.06604586,-0.0064753033,-0.03317141,0.09649188,0.043583333,0.0055142697,0.024174862,0.057584956,0.0105219055,-0.019634027,-0.06589374,0.010442331,0.0037722369,0.08572883,-0.04639795,-0.00047672165,-0.03797921,-0.010248608,0.014167202,0.029564656,-0.04178966,-0.11228887,-0.083380066,-0.0105211595,0.07402917,0.06281366,-0.005597858,0.047106773,-0.036900688,-0.024651939,0.0011322064,0.056494508,-0.13361228,0.008060026,-0.04386646,-0.051808685,-0.04497402,-0.002892136,0.063297786,0.010798576,-0.1120349,-0.027903719,-0.03264775,0.02611372,-0.010054313,0.015485206,-0.03273803,-0.066242315,0.053407628,0.05132715,-0.008452333,0.032093138,0.01629177,0.068565466,-0.0119813895,-0.014068956,-0.015438716,0.0049101575,-0.0843965,-0.025549857,-0.032079346,0.0028840355,0.0070186243,-0.02730594,0.017202796,0.05155019,0.07563469,-9.072768e-05,-0.038496763,-0.033543024,0.024217924,0.10688282,0.07252256,-0.026352545,-0.001805045,-0.05396662,-0.040777523,0.013134267,0.0064993533,-0.02772555,0.020359527,0.033332396,-0.07383808,-0.06527586,-0.010199196,-0.020129744,-0.023715286,0.08394801,0.07725623,0.02949556,0.11239174,-0.069600716,3.3902366e-33,0.08166262,0.078192234,0.03504312,-0.04798518,0.025451152,-0.011218511,-0.012126067,0.04017118,-0.042504977,-0.06125661,-0.04374547,-0.030137636,0.06947169,-0.007508298,0.010787646,-0.041517664,-0.0037226963,0.006745273,-0.009909614,-0.017458845,-0.043316815,0.099757686,0.012874966,0.03514669,-0.0077333637,-0.018310789,-0.03155122,0.013420415,0.14497748,-0.0018308772,-0.09458925,-0.022540025,-0.12120151,0.006192511,0.035300024,0.0005862521,-0.059319027,-0.012819658,0.059692014,0.066225685,-0.03447727,0.088960126,0.022867441,-0.0957781,0.047585536,0.014214765,-0.061870772,0.10199089,-0.068988994,0.02133518,0.0328749,0.0015064512,0.055592485,-0.050328325,-0.03564828,0.02793479,-0.0037099847,0.014949725,-0.006926237,0.035991102,-0.046205245,0.013097708,-0.069713764,0.007957231,-0.033465143,0.05305986,0.008371292,-0.084410384,0.03758303,0.12534526,-0.0044234274,-0.0038178538,0.034108303,0.07963928,0.12591897,-0.06147197,-0.04341708,-0.0026243622,0.056500357,-0.024122275,-0.001069966,0.03794953,0.044683527,0.0102314,-0.022812352,-0.043332208,0.0068347543,0.0025771558,-0.01772246,0.026636887,-0.0067553734,-0.060012475,-0.020690983,0.030264767,0.037345894,-3.5029162e-33,0.10931198,-0.06992644,0.031321533,-0.060075253,-0.08040755,0.011360419,0.022092309,0.022002907,0.012723143,-0.006148476,0.14740613,-0.03220818,0.060512394,-0.04436268,0.021119742,0.010624102,0.017949363,0.017613987,0.0029850209,-0.028495329,-0.023402182,-0.005401484,0.027439985,0.0016122803,0.060051695,0.06222133,-0.041218687,0.07871332,-0.0057519646,-0.014298257,-0.09351742,-0.005249239,-0.045207996,-0.07290528,-0.062464803,0.06280957,-0.0031826275,-0.025325863,-0.026553577,-0.0040919404,0.06064298,0.052598458,0.02660226,0.09012477,-0.023370923,0.051826,-0.0384952,0.056888267,-0.064675115,-0.07792146,-0.040710077,-0.03744569,0.01056418,-0.025862,0.03897285,0.10692796,-0.0050745257,0.032836277,0.0073400396,-0.03309587,-0.04762596,-0.06799067,-0.0023076432,0.02015168,-0.0051359395,-0.011715403,-0.0645084,0.06352903,-0.0080081625,-0.05927356,0.0821561,0.044458997,0.062446028,0.03763204,-0.043569766,-0.030708913,-0.022951718,-0.11236818,0.025397662,-0.049585775,0.008126703,0.0010245008,-0.039417487,-0.06196992,-0.024185104,-0.03132163,0.08869451,0.07743724,0.008515021,0.08606254,-0.014766641,0.013862909,0.0101439515,0.0702086,0.03903546,-3.6180523e-08,0.08728969,0.003881752,0.02580073,-0.07683994,-0.013442488,0.059084646,-0.034254856,0.006223252,0.0386395,-0.030877523,0.022237197,0.084917165,-0.045921378,0.048187394,-0.03230109,0.029194482,-0.060085613,-0.085299574,-0.0021820657,0.00066511036,-0.05152156,0.040279835,-0.10691844,-0.0043860017,-0.036737237,-0.050513078,0.046056353,0.03383012,-0.07672358,-0.052279685,-0.055720355,0.021898929,-0.0058774156,-0.061533898,-0.04799732,0.003517944,0.018016052,-0.01091713,-0.016173739,-0.04372787,0.0448813,-0.009243798,-0.0987448,-0.00931731,0.02423383,0.006589966,0.002153609,-0.016745038,-0.012871507,-0.0008215449,0.0061456137,-0.031574585,0.05310385,-0.025270376,-0.075279884,-0.0112028625,-0.050793823,-0.073868066,-0.064564,-0.046913188,-0.012678013,-0.029173084,0.21540019,0.06248064 +4.1.1.94,"The enzyme, which exists in all vertebrates, decarboxylates ethylmalonyl-CoA, a potentially toxic compound that is formed in low amounts by the activity of EC 6.4.1.2, acetyl-CoA carboxylase and EC 6.4.1.3, propionyl-CoA carboxylase. It prefers the S isomer, and can decarboxylate (R)-ethylmalonyl-CoA with lower efficiency. cf. EC 7.2.4.3, (S)-methylmalonyl-CoA decarboxylase (sodium-transporting).",384,1.0,-0.014439774,-0.060604952,-0.0032172704,-0.043934926,0.037589066,0.02756829,-0.098825745,0.048759893,0.00795548,0.023494437,0.015260401,-0.08291867,-0.051602505,0.05998095,-0.05358865,0.0049815676,0.024528505,0.020507466,-0.02834608,0.012634791,0.050740696,0.042903684,-0.055944815,0.029425746,0.05315942,-0.0035958292,0.034800015,-0.07264694,0.027592635,-0.12508032,0.024870662,-0.04139235,0.035828486,-0.010037402,0.05126335,0.036139842,-0.033837285,-0.07857229,0.042239685,0.046542615,0.0018708542,-0.04219823,-0.029692741,-0.019426154,-0.058897864,-0.08786029,-0.02321706,-0.06587442,0.047037993,-0.001955085,0.048354976,0.009949267,-0.02352643,0.013572046,-0.040033165,-0.06459361,-0.014218441,-0.03576448,-0.12894656,0.009004584,0.10886166,0.036467012,0.025763158,-0.005346825,0.020879118,-0.0011808202,0.030866418,-0.009698989,0.049711253,-0.022868956,-0.05193587,-0.09570731,0.018373223,0.0377534,-0.06486354,-0.014072929,0.010968898,-0.05603044,0.07877656,0.024327343,-8.952954e-05,0.0433258,0.010648304,0.024670182,0.062288035,0.024620717,-0.020192651,0.05166341,-0.023269769,0.026713539,0.0653676,0.00018300598,0.06840348,0.0053186915,-0.004052087,0.0693877,-0.048222236,0.038874853,0.008749183,-0.039732184,0.019922461,0.092657946,-0.104486465,-0.08914657,-0.008648777,-0.03618135,-0.03473408,0.008543276,0.017248672,0.026910424,-0.03664446,-0.031068722,0.017202698,0.03356841,0.0065627354,0.087924175,-0.02431891,-0.04429621,0.033792216,0.012952156,0.04902931,-0.019810086,0.043997113,0.08392002,0.04833128,0.043876808,-0.097015254,7.2972233e-34,0.017342918,-0.016805226,-0.00037893563,0.031711612,0.020664362,0.0033393255,-0.078425765,0.14474852,-0.05679866,-0.028369453,-0.037921797,-0.01771129,0.04401586,0.013691706,0.044928104,-0.008610253,-0.013458202,-0.013787947,0.05406568,-0.064789474,0.008181285,-0.008970423,-0.036518484,0.06823034,-0.036309436,0.028657874,-0.08306272,0.02877624,0.07262949,0.013422669,-0.03521886,-0.17185758,-0.010376998,0.04030738,0.024717014,-0.0049830144,-0.069794305,-0.008382479,-0.045458023,0.10686673,0.08013235,-0.0318336,0.008003398,-0.018672464,0.07579177,-0.036738403,-0.07017278,0.07050598,-0.032704607,-0.02286622,0.030211426,-0.03467218,0.06771345,-0.052064974,-0.04482695,0.080058165,-0.058988884,-0.04420095,-0.0004873621,0.02665668,-0.01943174,0.06778746,-0.050375324,0.023704944,0.027419094,0.01183291,-0.09054563,-0.09082633,-0.05171067,0.0413255,-0.018422421,-0.012328134,0.007648992,0.0020814373,0.08513148,-0.04320652,-0.03879267,0.07056341,0.03893293,-0.022990989,-0.026239673,0.033600207,-0.02464298,-0.023378799,-0.016795155,-0.0178552,-0.017337045,0.0119716395,0.044719614,0.09443719,0.06845636,-0.091334835,-0.060775913,0.014423978,0.00874357,-2.0356421e-33,0.07527549,-0.073757514,-0.023062104,-0.021020953,-0.01918012,0.07950873,0.059463516,-0.008421956,0.1023471,0.010120784,0.044992566,-0.0009672776,0.051593624,-0.05461475,0.074969426,0.017218415,0.016867826,0.026275253,0.006850331,-0.05353359,-0.04091384,0.042740628,0.031070068,0.02186771,0.06128437,-0.030046262,-0.03388785,0.008738871,0.031293772,0.026094673,-0.026865587,0.071890764,0.011162094,-0.010234695,-0.12356718,0.043534122,-0.07579153,-0.0043057334,-0.034118135,-0.0114036575,-0.055371657,0.06870019,0.013983087,0.037952434,0.05880334,-0.01998929,-0.06344622,-0.008909222,0.08426518,-0.06721995,0.028382018,-0.03910339,-0.01671357,-0.0021146268,0.018433023,0.116928674,-0.05533868,-0.007377251,0.064267986,-0.008350216,-0.011494952,-0.030452011,-0.04527917,-0.0257156,0.055471085,0.0073311976,-0.10081001,0.045236744,0.06381622,-0.09942671,0.13834956,0.020791493,-0.014128039,-0.00097538333,-0.048899204,-0.050881945,-0.06583895,-0.00051557634,0.03439474,-0.04177058,-0.02909755,0.029405437,-0.0011972294,-0.045134913,-0.040405046,-0.06781073,0.005888559,0.13251586,-0.006564499,0.028755482,-0.067311615,-0.05207646,-0.07786723,0.09963684,0.054913595,-5.086468e-08,0.041843433,-0.076644994,0.011231407,-0.07020732,0.052233282,0.07496981,0.084416695,-0.008604082,0.058239944,0.017552286,-0.029871235,0.02556592,-0.040912077,0.08057465,0.025023116,0.027437273,0.021296516,0.0590341,-0.018061703,0.014288042,-0.02146497,0.009318911,-0.046008635,0.04749886,-0.027406365,-0.021352608,0.083017305,0.0723485,0.010971462,0.020602126,-0.06302422,0.043125514,0.018762553,0.0069082677,-0.0964033,-0.00909679,-0.0049214712,-0.024153642,-0.07270645,0.11706507,0.008987236,-0.04422762,-0.061627276,-0.019245485,0.032570485,-0.045586918,0.05240694,0.029410219,-0.0007948379,-0.053132076,0.044627693,-0.007905902,-0.08699483,-0.005739918,-0.0236145,-0.036605455,-0.04908752,-0.11118233,-0.032279324,-0.042477958,0.040289078,0.038222384,0.21068357,-0.0085376 +4.1.2.50,"Binds Zn2+. Isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine.The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin [2].",384,1.0,-0.14509417,-0.07876522,-0.110632844,0.02504007,0.07954615,0.032049622,0.023714412,0.0864424,0.05231157,-0.025344577,0.05329384,-0.025552193,-0.06914222,0.06400691,-0.0626273,0.008218563,-0.082750484,0.029362699,-0.03172844,-0.03214807,0.038794752,0.090716876,0.0026062964,-0.035679746,0.0035204387,-0.017609792,0.023551272,-0.023805484,0.05803912,0.016668923,-0.014741976,0.00038652171,-0.03601148,-0.041561197,0.049621467,0.01306941,0.064543195,-0.0647116,0.08756747,-0.030627254,0.10208976,0.01373858,0.0039393683,-0.053188276,0.05638861,0.056609154,0.08592073,0.055042088,0.017023526,0.0038826505,-0.036968105,-0.00045908196,-0.043768473,0.07022385,0.019693611,0.02101988,-0.07674417,0.0077700964,0.0016310264,0.025145082,0.057040956,0.04168423,0.04295365,0.022099495,0.043108217,-0.066397026,-0.015884005,-0.006413782,0.0009895617,-0.044762176,-0.09268465,0.0024977336,0.048385095,0.018830877,-0.011714238,0.068053775,-0.027684225,-0.09566798,-0.032120295,0.0062362775,0.050309263,-0.049687527,0.07522384,0.15914352,0.051527612,-0.018710013,0.005644908,0.040366072,0.00076241605,0.045754507,0.023667682,0.008320674,0.064904645,-0.061720945,-0.087042965,0.013983606,-0.014147089,-0.01409493,0.021412814,0.02664167,0.0029942242,0.0057987664,0.011987831,-0.0929876,-0.032361336,0.06314501,0.06732194,-0.02199957,0.03131337,0.053476363,-0.007670089,-0.02669632,0.019581072,-0.06341583,0.0087022735,0.06979876,-0.006806816,-0.007927246,-0.061823733,-0.016906302,-0.015472999,0.03444938,-0.03762731,0.055897284,-0.050051074,0.017243601,-0.1373447,5.4538056e-33,0.0030597888,0.0639698,0.032393254,0.0037745587,0.02654718,0.007556643,-0.033481784,0.00061850547,-0.042565517,0.032951955,-0.07285284,-0.16185363,0.04104033,0.008091855,-0.012047159,-0.02694691,-0.020828355,-0.022493377,0.04209212,0.012668783,0.046937857,0.04753979,-0.08988209,0.007853874,0.11398613,0.08642783,-0.03846537,0.010723291,0.053012196,-0.05105832,0.025454056,-0.061875615,-0.101899184,-0.0029653653,0.13759422,-0.07909077,-0.033005662,0.0021020782,-0.029782712,-0.037056886,0.036155365,-0.024774885,-0.09140762,0.023141487,0.024858851,-0.04791884,-0.041195538,0.01593481,0.08697628,-0.09188591,0.008480087,-0.060572088,-0.013029256,-0.002073251,-0.034221727,-0.0067168423,-0.03380736,0.027932793,0.07535891,0.056939535,-0.012705254,0.0092481375,-0.040574856,0.033432603,0.017732304,0.09554959,-0.07188877,-0.091491126,0.007702592,0.037810173,-0.062970035,-0.042560603,0.05774324,-0.052248117,0.060987618,-0.024634687,-0.079392605,-0.009431519,0.061018687,-0.02523871,-0.0071817166,-0.07111849,0.03362745,-0.0075053396,-0.09796716,-0.030786268,-0.045967087,-0.030068804,0.054264575,0.06472023,0.018790796,-0.1585908,-0.023708131,-0.032676302,0.0070990347,-4.541331e-33,0.026144708,0.013526614,0.02961738,-0.084575124,-0.066259444,0.07178076,-0.053629495,-0.07692217,0.03304684,-0.017411262,0.033834696,0.03675204,0.07098599,-0.010371735,-0.012102053,0.050381657,0.015978683,0.07117701,0.07017961,-0.05323075,0.017423647,-0.020535972,0.0056462693,-0.0075515187,0.008799662,0.07283213,0.093444884,0.027545994,0.07714993,0.060820863,-0.08931161,-0.059796028,-0.061729714,-0.09547351,-0.06762913,-0.0042267353,-0.047559455,-0.012344736,-0.059498947,-0.06294853,0.0047921906,-0.054572523,-0.00020104554,0.121819235,0.01776215,0.013757275,-0.034152605,-0.02093624,-0.015772281,0.015982075,0.026916964,0.027223092,-0.07286145,-0.020796506,0.051038865,0.025006514,0.08834964,-0.008308506,0.026902739,-0.060247958,-0.0023137075,-0.10225766,0.006635546,-0.04480672,0.075547844,0.027609836,0.013129565,0.1543908,0.034886334,-0.046084337,0.08367178,0.045572534,0.096912354,0.013032591,-0.064392745,-0.033404067,-0.027349139,-0.06216783,0.09046906,0.010130236,-0.025302336,-0.052216265,-0.024795787,-0.011766412,0.025176905,-0.008161761,0.065204106,0.07570432,0.02869106,-0.034667965,-0.0076770247,-0.002514461,0.036419556,0.023743063,-0.061233655,-4.153427e-08,0.02419964,-0.11037656,0.0052149827,-0.027603758,-0.030965216,0.0012888657,-0.0037041975,0.06372766,-0.03432279,-0.0049892706,0.001524684,0.06164703,0.05481064,0.011328207,0.08535741,0.023983905,-0.017221533,-0.04265329,-0.0100171035,-0.05676423,9.8016615e-05,0.023980644,-0.07842784,0.022966528,-0.0015432922,-0.08540727,0.002171332,0.06491916,-0.006410511,-0.017175075,-0.0064890054,-0.0009438722,-0.010841765,-0.031102628,-0.042501394,-0.0009354822,-0.06183904,-0.06250759,-0.010275422,-0.025516149,-0.012524149,0.05854659,0.012020801,0.03194492,-0.039226625,-0.0026375495,0.055565123,0.009542825,0.03590555,0.032506976,0.026298942,-0.006736652,0.012699023,-0.035467602,-0.05968771,-0.0024172643,0.0266442,-0.012961311,-0.0049910764,0.053852566,-0.059166636,0.0074517494,0.113703616,0.035912797 +4.2.1.132,"This enzyme catalyses a late step in the bacterial steroid degradation pathway. The product, 4-hydroxy-2-oxohexanoate, forms a 2-hydroxy-4-hex-2-enolactone under acidic conditions.",384,1.0,0.010727111,0.0049984446,-0.05952836,-0.05425438,0.016409159,-0.0075430525,-0.07647988,0.048372958,-0.06897765,-0.023126476,0.023062468,-0.066359,-0.03122569,0.03831308,0.0045734434,0.07865582,-0.08935955,0.023148386,0.05038532,-0.04337615,0.07336515,-0.0061113345,-0.030553112,0.017342638,0.040220656,0.08836664,0.056050844,0.018731,-0.04741075,-0.06913316,0.050459787,-0.044627976,0.071638815,-0.103408515,0.042270694,0.065645166,-0.023689203,-0.087348364,0.0797197,0.007950191,0.012624719,-0.015342191,-0.06667664,0.0015017149,0.007586784,-0.023197774,0.04547708,0.05983128,0.0706785,-0.064389825,-0.0026003742,-0.08925977,0.008009839,-0.0018228045,0.01463886,-0.012157659,-0.037860893,-0.009013567,-0.033757824,0.082160965,0.11701595,-0.014113629,-0.029593958,0.04455232,0.010437357,-0.04394015,0.022559466,-0.082543515,-0.044238742,0.014167467,-0.023672719,-0.031989433,0.003276791,0.06927964,-0.021899668,0.049363803,-0.010862442,-0.079391174,0.025800295,-0.033146787,0.03830572,0.034513876,0.025085403,0.088172324,0.088103764,-0.01689961,0.020190697,-0.083601005,0.027482191,0.10818853,0.019541632,0.033636894,0.038100448,-0.025979333,-0.0012884573,0.053890586,-0.020822456,0.06362574,-0.019377232,0.024822077,-0.056907687,0.057471797,-0.063142896,-0.075212985,0.014569185,0.04371675,0.044412944,0.117157444,-0.014268805,0.048206996,0.0029035779,-0.051103137,0.015484608,-0.007869031,-0.022036264,0.13904636,0.037502274,-0.003902528,-0.12752813,-0.03922557,-0.009123824,-0.024019787,0.030059332,0.02801569,-0.04605363,0.015811253,0.02437643,-9.9246e-34,0.056433942,0.025215182,-0.026660476,-0.028706243,-0.0138051445,-0.023400126,-0.04401752,0.013704156,-0.05036649,-0.060057297,-0.04379274,-0.008176489,0.0376769,0.0694377,-0.009287312,-0.048223726,0.057515707,0.100026734,0.0735305,0.02613326,-0.0015801452,-0.00072869466,0.0008606854,-0.04497468,-0.065586306,0.00036891564,0.03334321,-0.0038524522,0.036366347,-0.016391624,-0.032309126,-0.05034832,-0.07287542,-0.063248225,0.053089432,-0.067552514,-0.021075161,-0.037595827,-0.0046783015,0.10322241,-0.007457533,0.06602239,8.3018305e-05,-0.026516173,-0.008699491,-0.054603975,0.008142174,0.099942334,0.11492816,-0.0064550317,0.032268148,-0.008063727,0.050189365,-0.049415074,0.011207983,0.016863609,0.05159821,0.0056185625,0.018602932,-0.022055851,0.016957052,0.06741377,-0.031355463,0.03565451,-0.0327619,-0.05441831,-0.009997567,-0.10309783,-0.07728375,-0.015019863,-0.061070144,-0.018139256,0.06519832,-0.017233081,0.024413122,-0.034162827,-0.023734625,0.017191622,0.039427627,-0.06221356,-0.024951747,-0.05744715,-0.0017554663,0.009181696,0.020319574,0.054845322,-0.004807165,-0.05040639,-0.012188061,0.08935759,0.0074941567,-0.06490239,-0.08532905,0.030300615,0.046563487,4.624284e-34,0.029049257,-0.07225933,0.006637414,-0.10089939,-0.10592932,0.095433444,-0.037453882,0.041980535,0.029996766,0.05603228,0.07607662,-0.013488826,0.06319355,-0.08420277,0.034971215,-0.027427241,0.018930504,0.0038591737,-0.10200395,-0.08785879,0.087616414,0.10731499,0.015352291,0.037436765,0.027727097,0.014439627,0.024090089,0.045145757,0.062433925,0.072332524,-0.043902114,-0.054601338,-0.035200864,0.036350552,-0.014022548,0.105262816,-0.006095504,-0.04444882,0.016568445,-0.017181551,-0.04215118,0.013319495,0.018003136,0.022344232,0.04975708,0.04744513,-0.07694654,0.11519548,0.014755629,-0.025796162,0.046146136,0.010309799,-0.064844206,0.010968654,-0.022403235,-0.00081245956,-0.044877663,-0.015247934,-0.03118945,-0.06281277,-0.016911255,-0.07146588,0.057675973,0.002389972,0.009927852,0.047193956,-0.039363384,0.005881929,-0.017294655,0.009878166,0.009802717,-0.033124212,-0.051775802,0.031572558,0.0043110326,-0.011473607,-0.071000315,-0.10175658,-0.04428346,-0.01966016,-0.036400672,-0.02258532,0.0025589145,-0.06063062,-0.007778907,-0.075403675,0.015593928,0.11800038,0.0055676345,0.09107917,0.02373157,0.007638115,-0.083581224,0.03636078,0.04613011,-3.1838475e-08,0.017064324,-0.042871885,0.10116897,0.0036189265,-0.03634444,0.021377781,0.01187084,0.014255479,0.18237236,-0.11460241,-0.006516334,0.1025727,0.024372483,0.0059242425,0.036859334,0.012759035,-0.012477918,-0.0033526025,-0.026119364,-0.07131152,-0.06841389,-0.07413521,-0.01811325,-0.01664658,0.00588041,-0.06054781,0.036813825,0.082428455,-0.027273925,-0.02173384,0.06702575,-0.0026241585,0.008316838,0.00095553586,-0.013206157,0.058271997,-0.029566528,0.004193075,-0.013901135,0.051678084,-0.061925203,-0.030416895,-0.09298888,0.037018985,0.026125327,0.07668094,0.0054038274,0.08446694,-0.011890314,-0.04145933,0.02025933,-0.036079444,-0.008915487,-0.040786326,-0.097681135,0.033230275,0.010013042,-0.07470942,-0.012006201,-0.04865355,-0.0059570493,0.016116591,0.18605946,0.0072195223 +4.2.3.105,"The enzyme from Solanum lycopersicum (tomato) gives a mixture of tricyclene, camphene, beta-myrcene, limonene, and traces of several other monoterpenoids. See EC 4.2.3.117. (-)-camphene synthase, EC 4.2.3.15, myrcene synthase and EC 4.2.3.16, (4S)-limonene synthase.",384,1.0,-0.032867175,-0.059198033,-0.06709896,0.0070918514,0.05789795,0.029088628,-0.0030943428,0.019948509,0.027592465,-0.029549101,0.07986988,-0.08088046,-0.0070871804,-0.011144851,-0.020959638,-0.0032005205,-0.050349206,0.07937256,-0.019179307,-0.06871379,-0.025501758,0.053795338,-0.026854405,0.04564944,0.027702585,-0.020709679,-0.0018062063,-0.035476334,-0.0115580205,-0.06923775,-0.036542308,0.035214808,-0.02413611,0.017654985,0.0070760325,0.0002462168,-0.017563254,-0.05203342,0.08911358,0.043839242,0.087408625,-0.0364406,0.04152158,-0.052901383,0.016192848,0.00152261,-0.07888716,-0.014559845,0.017188888,-0.042551488,2.707533e-06,-0.05726771,-0.008032158,0.002094686,0.010785937,-0.012294398,0.05470453,0.048442516,-0.0051355986,0.108323425,0.048035312,0.009224156,0.006113492,-0.013889021,-0.11012717,-0.008912973,-0.030579166,0.033761106,0.038767334,-0.053373724,-0.04336442,-0.14745544,-0.10079037,-0.009093003,-0.04535334,0.060198173,0.026731355,0.009796391,-0.04884833,-0.038419276,0.011631724,0.024753792,0.019303627,0.019263545,0.04931571,0.038431086,0.025072258,0.021936445,0.07914968,0.10657759,0.038418528,-0.019341279,-0.055145327,-0.0026507406,-0.0703862,0.056928217,0.10607922,0.00014306555,-0.009134888,-0.0136468755,-0.01290765,-0.042709727,-0.0724543,-0.07433152,-0.09722404,0.039546955,0.070508495,-0.06524352,0.03153496,-0.008082243,-0.0092655895,0.02242911,0.015579724,-0.05595308,-0.029006602,0.05451075,0.038218264,-0.011949179,0.030167349,0.057719935,-0.009474106,0.030599171,0.09010358,0.045014765,-0.03511631,0.014941365,-0.056409795,8.58834e-34,0.0008948587,0.09525411,0.0016277265,0.02825031,0.023121811,-0.02105755,-0.051388595,0.09453328,-0.023629913,-0.13237712,-0.1194672,-0.010742527,-0.04802019,0.03939567,-0.051210836,-0.0024787476,0.0057157744,-0.026480807,0.018455302,-0.070335664,-0.09925344,-0.08629423,-0.077174775,0.0069692447,0.036136337,0.003000623,0.01475379,-0.035404585,0.10033498,-0.039890233,-0.06753995,-0.04429872,0.035473973,0.050828665,0.04193757,0.008062233,-0.042437453,-0.047485236,-0.043214865,0.05772091,-0.0012098904,0.028405713,0.010886755,-0.006482424,-0.00030418774,-0.024495607,-0.08462761,0.06938804,0.04073122,-0.020283146,0.0065374095,0.02605181,0.038709413,0.01818307,-0.0833386,0.06833525,-0.023982892,0.002370895,0.05836005,0.05712509,-0.019298472,0.08121569,-0.035788078,-0.026933048,-0.02789609,0.123975016,-0.15478976,-0.024217982,0.0107383765,0.009211014,-0.016256785,-0.05757082,0.081745595,0.020946853,0.13973214,0.031628564,-0.030891027,-0.00012761391,-0.007874362,-0.017096415,-0.05265029,-0.0066991863,0.044762734,0.0029850975,-0.06011436,-0.027653627,0.0020018036,-0.014601578,0.08372273,-0.0034626578,0.038950935,-0.03299878,-0.020267585,-0.01859594,-0.031364363,-9.692887e-34,0.013086626,0.017944945,0.036223404,-0.07541012,0.033451434,-0.0065393164,-0.07456734,-0.1757962,0.041320283,0.025870726,0.040292464,-0.06720509,0.049290147,-0.087852746,-0.02804426,0.03751501,0.048154857,0.087629944,0.024660414,0.009869063,-0.034640174,0.020910785,-0.014392357,-0.005986073,0.009386009,-0.045081113,0.0078022694,0.07746376,0.076131046,0.06555119,0.022484504,-0.06598015,0.007929333,-0.0010639884,0.017650489,0.076806836,-0.013623697,-0.011790969,0.015771972,0.060113184,-0.06667621,-0.022207145,-0.0110657485,0.13033937,0.07441409,0.016888522,-0.06296106,0.016320754,-0.044424657,-0.03340774,0.06044922,0.020821722,-0.03753494,-0.02943657,0.007034753,-0.018876553,0.06743886,0.017484767,0.026427148,-0.04621714,0.048238084,-0.06753247,-0.06359927,0.004007116,0.030767202,-0.014370792,-0.049117975,0.03603362,-0.006546183,-0.007822002,0.08784866,-0.012688144,0.036755983,0.06652167,-0.038459737,-0.050754327,0.045506194,-0.07441175,-0.004379471,-0.080241755,-0.020947263,-0.052248705,0.013314753,-0.07248229,-0.02236173,-0.027188856,0.035082914,0.07612179,-0.040798534,0.036529362,-0.025613049,0.0840316,-0.061727364,0.12690187,0.112426095,-3.8910436e-08,0.08797352,-0.07010083,0.033688996,0.019814119,0.01508227,-0.032594755,0.051801994,0.018379997,0.043233722,-0.009680269,-0.072888136,0.014737216,0.004163803,-0.02719462,0.0831612,0.048861146,0.013499412,0.055110183,-0.010947647,0.062067352,0.03923077,0.05498239,-0.08890205,-0.07781578,-0.026663,-0.0879431,0.017247017,0.06325205,-0.0034578454,-0.025306117,0.0658906,0.017622693,-0.00072185,-0.056795068,-0.05760655,0.058581892,-0.037651148,-0.026233776,0.015206991,0.041876,-0.039436202,-0.023854515,-0.049220715,0.022391407,-0.012881478,-0.004109102,0.014695504,-0.050190303,0.06019379,-0.009177195,0.059677687,0.012171206,0.07475076,-0.014757273,0.01194189,0.017717816,-0.0070379144,0.049025986,-0.006109906,-0.08927605,-0.09067668,0.0505031,0.18184435,0.0021881643 +4.2.3.106,"Widely distributed in plants, which release beta-ocimene when attacked by herbivorous insects.",384,0.99999994,0.019159127,-0.03163424,-0.017434811,0.095120676,0.06428954,0.0604446,0.009668196,0.0066761402,0.082676224,0.08471632,0.089068525,0.02339803,-0.033238534,-0.021549331,-0.0060325083,0.09388471,0.027075592,0.024413995,-0.012774425,0.007734323,0.017700594,0.059074994,-0.0008569063,0.008006969,-0.030129412,-0.07652072,-0.08959613,0.00530745,0.032290827,-0.12149853,0.025321534,0.06747939,0.080642685,-0.03091802,-0.040193234,-0.01896653,-0.012035479,-0.16085675,0.060957618,0.04123699,0.04243134,-0.0061503793,-0.04770761,-0.014952958,-0.074848816,-0.020756874,-0.042088307,0.04420038,0.05410781,-0.08060367,-0.0027281807,-0.08596318,-0.055218972,0.095525794,-0.011743441,-0.05233282,-0.0030862389,-0.03190762,0.04961755,0.044237603,0.052584495,0.042087402,-0.021556241,0.03860351,-0.021740658,-0.0042333184,-0.11472781,-0.022411399,0.018204987,-0.028186157,0.056936286,-0.06408443,-0.040055823,0.014013406,-0.012223528,0.0812452,-0.04090131,-0.012957027,0.042966194,0.008423921,0.03458379,-0.015300166,0.028767932,0.005831665,0.05750827,0.03890667,0.027676845,0.07723514,0.06657812,0.050223682,-0.026704738,-0.013631946,0.024700353,0.019135667,-0.039355602,-0.045692574,0.10632543,-0.12168607,-0.023808904,0.030674674,-0.021569474,-0.008690509,-0.015708322,-0.039242916,-0.07814019,0.035723105,0.014650598,-0.04121171,0.018862706,0.037566256,-0.011565202,-0.021362683,0.022951268,0.006395453,-0.09066557,-0.030842999,-0.014772292,-0.012231464,0.0029276174,6.065998e-06,0.03195911,-0.038693793,-0.025321016,0.011690999,-0.018385971,0.04864083,-0.13091107,-1.2235887e-33,0.07761847,-0.032768056,-0.05232699,-0.043233283,0.016341427,-0.032403488,-0.047579926,-0.021403547,0.049753513,-0.07390633,-0.0677149,-0.093244776,0.019014549,0.11137411,0.0656278,0.0220012,0.0147465,0.027705956,0.093295574,0.00727432,-0.06981826,0.0005024207,-0.053824794,-0.023778643,0.074989855,0.049776103,-0.049815003,-0.017914288,-0.009481774,0.023649724,0.13081476,-0.0657538,-0.021526232,0.07340659,0.06523929,0.027112382,-0.09262903,-0.039168097,-0.06380572,-0.0058953175,-0.0011863627,0.037982844,-0.03969804,-0.023311019,0.09702475,-0.021748709,-0.06428218,0.030772049,0.06525723,-0.01578776,-0.0031628418,0.06845204,0.08151969,0.042172655,0.008594705,0.04078616,0.0010918583,-0.024930554,-0.040650286,0.03162277,-0.041661132,0.030565258,0.04156728,-0.050731145,0.037401635,0.0079523735,-0.11980847,-0.05642985,-0.04707834,-0.0054749507,0.030391539,-0.036771,-0.018978124,-0.06294936,-0.03610142,0.006288919,0.059796356,0.025340926,0.015330086,-0.027965479,0.04774064,-0.081300825,0.029686073,0.008763285,-0.028843518,0.073589854,0.03599742,-0.028991582,0.026322102,0.081597626,0.08767419,-0.046906464,-0.05935215,0.027918348,0.017442996,1.3120849e-35,0.004693947,-0.0030760884,0.0056448276,-0.028677382,-0.07225384,0.07918831,-0.15262274,-0.02101718,-0.035416853,0.010174046,-0.12954761,0.08638721,-0.0035874296,-0.020559072,0.05336381,-0.09976563,0.09985331,0.05293033,-0.005717088,-0.025750997,-0.08154699,0.012941539,0.08846495,-0.0736847,0.07933449,0.0025683825,0.034568746,0.013941729,0.026626889,-0.0016046566,0.0007197232,0.029193621,-0.006863414,-0.045884274,0.053256102,0.061710082,-0.020890778,-0.003728636,0.06048066,0.031293012,-0.05905,0.0034859644,0.0013837127,0.009907188,0.07193655,0.030039474,0.0056495937,0.027911548,-0.0278951,0.043817125,0.046350162,0.010719678,-0.04164698,-0.013081658,0.013652308,-0.012560825,0.020353261,0.015162619,-0.023169342,-0.11307153,0.023461547,0.0051797708,-0.029515123,0.028300948,1.0146862e-05,0.058420096,-0.018442962,0.07182833,-0.031064037,0.05379273,-0.033043735,0.0055197263,0.016619053,0.05545224,-0.047323626,0.03276856,-0.061484184,-0.121801026,-0.0059601646,0.017804375,-0.11068525,0.04482188,0.0006582695,-0.0434183,-0.026698342,-0.045665685,-0.025292039,0.03838626,0.043722022,0.03110636,-0.011572754,0.036186844,-0.0049060443,0.024059068,0.085081555,-2.119328e-08,0.06627226,-0.059854742,-0.013508259,0.0056315786,0.01635813,-0.058062013,0.02163055,0.010099592,0.045988362,0.001006111,-0.028458389,0.087341465,0.08971832,0.03221522,0.059916787,-0.024593286,0.024653634,-0.04045846,-0.08203436,-0.057714503,-0.07381076,0.028213942,0.0341677,0.019129721,-0.029263044,-0.12847863,0.016438639,0.020065537,-0.042864792,0.010809793,0.077941135,0.038353566,-0.008260962,-0.10309209,-0.050693713,0.10878572,0.042688973,-0.019614235,0.08886436,-0.0815186,-0.07205059,-0.014283596,0.043240376,0.027446203,-0.030889858,0.012679401,0.026313547,0.017967125,0.0068378346,-0.075911604,-0.011605081,-0.03321473,-0.016889537,-0.044331737,-0.11488981,-0.033865236,-0.012049129,-0.028280227,0.071178496,-0.039363913,-0.037552062,-0.023101654,0.10071902,-0.03996202 +4.2.3.107,"The enzyme reacts with (3S)-linalyl diphosphate twice as rapidly as geranyl diphosphate, but 25 times as rapidly as (3R)-linalyl diphosphate. It is assumed that (3S)-linalyl diphosphate is normally formed as an enzyme bound intermediate in the reaction. In the reaction the 5-pro-R hydrogen of geranyl diphosphate is eliminated during cyclopropane ring formation [1,2]. In Picea abies (Norway spruce) and Picea sitchensis (Sitka spruce) terpinolene is also formed [4,6]. See EC 4.2.3.113 terpinolene synthase. (+)-Car-3-ene is associated with resistance of Picea sitchensis (Sitka spruce) to white pine weevil [6].",384,1.0,-0.07017725,-0.051732555,-0.08151556,-0.0044322386,0.063113086,0.013977717,-0.04286078,0.029871643,0.09029952,0.013032299,0.015990235,0.007720499,-0.040094323,0.0051288013,-0.017341156,-0.00882311,-0.059670646,-0.01902356,-0.0075683584,0.0138774505,0.046092458,0.04170411,-0.023926033,0.04020358,0.022123149,-0.053792708,-0.007225351,0.04317263,-0.020058244,-0.061098017,-0.040798478,-0.015829688,0.02598112,-0.010540958,-0.026923705,0.07760619,-0.09140048,-0.113369904,-0.004367807,0.058485866,0.031031378,-0.055361375,-0.041645553,-0.0928056,-0.05706234,0.04055042,0.011405977,0.045838874,0.003797957,-0.049067866,-0.047306035,-0.08333887,-0.020226784,-0.053554893,-0.005409035,-0.07780393,0.026172843,0.011032553,-0.00767326,0.009800844,0.035645593,0.03604907,-0.043934558,-0.018291952,0.034666233,-0.02492932,-0.033318672,0.013823686,0.02572102,-0.030583436,-0.098464034,-0.02840196,-0.049356706,-0.016333591,-0.01411027,0.0411418,0.03107943,0.018394232,0.03763995,-0.106806405,0.0099091,0.01912567,-0.041697517,0.025352832,-0.002841187,0.008884859,-0.0032028384,0.07520728,-0.019375017,-0.041771546,0.06650352,0.018948149,-0.03400816,0.00551791,-0.029705083,0.16788141,0.008723681,-0.057588056,-0.03559532,-0.05141293,-8.55883e-05,0.012118839,-0.033443127,-0.114391625,-0.06619008,0.03471484,-0.039031744,0.09937467,0.02192438,-0.015139978,-0.028464206,-0.0027257989,0.048738677,0.053283937,-0.08539559,0.0201315,0.009786719,-0.10548012,-0.010574838,-0.03146767,0.022273766,0.01714732,0.023095973,0.07910398,0.017340973,0.058594413,-0.07549919,5.011689e-33,0.07560752,0.083672345,-0.030243248,-0.029769266,-0.07742516,-0.010039598,-0.101404175,0.021910595,-0.070011534,0.016808642,-0.030484403,-0.14253825,0.11904327,-0.059669755,-0.03301457,0.036709033,0.015909916,0.026264457,0.022971895,0.061311785,-0.03444912,0.031481538,-0.09172151,0.04619369,-0.011277327,0.10420335,0.010873993,-0.059494127,0.023827797,-0.055773634,0.12299658,-0.07778556,-0.10523353,0.0482926,0.1204454,-0.08331725,0.027516877,-0.04947904,-0.061974533,0.030186446,-0.017583279,-0.0033137016,0.008627213,0.0024448566,0.10805166,-0.030773789,-0.047592755,0.06699517,0.01434225,0.049456667,0.07057817,0.038356856,0.11818107,0.015882628,-0.068094395,-0.002006496,-0.02623436,0.029907407,0.07664276,0.043652713,0.004357606,0.017534701,-0.04789989,-0.025205301,-0.0078407535,0.037515234,-0.114418566,0.040002175,-0.028549258,0.13701709,0.023884062,-0.039890047,-0.02714034,0.031005725,0.0004397302,0.041540295,-0.045863323,0.012134354,0.05606624,0.0622048,-0.019956367,0.0034332308,0.001360573,-0.011628684,-0.076964766,-0.07647452,0.04042226,-0.050950844,0.031018762,0.11680939,0.07526317,-0.044534326,-0.032845773,-0.042274993,0.024745815,-4.5641658e-33,0.11219563,-0.060119916,-0.032319434,-0.048348714,-0.05827012,0.018622907,-0.044178754,-0.0268283,-0.0061506624,-0.04714109,0.13668793,0.02472626,0.029331367,-0.020019395,-0.024855012,0.011322754,-0.004571113,0.0892905,-0.0063223722,-0.021137591,0.04341078,0.05172339,0.03859087,0.06601644,0.012368579,-0.0009768787,0.05097733,0.03439618,0.007924868,0.009009228,0.07537293,-0.013834392,-0.046059366,-0.013411402,-0.028035399,0.071028225,-0.009024421,-0.02585092,0.06638869,0.09103838,-0.021605035,-0.042848963,0.029198846,0.043615088,0.018426998,0.06898235,-0.07498508,0.030624513,0.00049155165,-0.0026963009,0.041739482,0.028080817,0.050947644,0.016604502,0.03457609,-0.027831985,0.043369655,-0.03422603,0.015559352,-0.051453274,-0.016760517,-0.018164108,0.019446941,-0.050252143,0.017896105,0.03970913,-0.06376428,0.044348177,0.097531796,0.01683576,0.042447653,0.055174552,0.035942625,-0.029963981,-0.05928383,-0.018023327,0.025546763,-0.01273454,0.020004332,-0.07425376,-0.0025675094,0.045679104,0.022767277,-0.08226672,-0.053078227,-0.04205295,0.0038028434,0.086940385,-0.012588687,-0.05735134,-0.053033143,-0.015517073,0.03911938,0.10613368,0.13589469,-4.4507292e-08,-0.028313149,-0.0060337167,-0.019795964,-0.042054817,-0.003395286,0.046101768,0.03266812,0.019996813,0.0027501027,0.0488373,-0.0034528123,0.02973061,0.036477152,-0.01051386,0.092549555,-0.03135851,0.019490367,-0.025293013,-0.033878442,-0.013694051,0.028217768,-0.039699208,-0.14263287,0.06548274,-0.018435033,-0.11353849,0.079006314,-0.030720586,0.06481087,-0.0635411,0.02399177,0.0745975,0.023627702,0.030604336,-0.014457391,0.044711042,-0.06875801,0.05022324,-0.014337214,0.027363418,-0.04699922,-0.04119652,-0.086906984,-0.03553679,-0.075078316,-0.054847773,0.04942682,0.049327966,-0.0008778451,-0.0337175,0.0020030534,0.0215351,0.018682228,0.023700418,-0.049372178,0.008916809,0.017910665,-0.04743234,0.04497358,-0.0032717881,-0.0022330969,-0.025794597,0.10414587,-0.0070939017 +4.2.3.108,"Requires Mn2+ or Zn2+. Mg2+ is less effective than either. 1,8-Cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)-linalyl diphosphate [1-3] while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate [4].",384,0.99999994,-0.01865995,-0.0072605717,-0.0071964934,0.0042937077,0.10384054,0.026947875,-0.038502067,0.064842895,0.047772363,0.015083975,0.058333255,0.011455747,0.009322184,-0.06727933,-0.016474439,0.087746,-0.002965462,0.03989066,-0.030978048,0.00924664,0.106885046,-0.004390731,-0.024075275,-0.04639968,0.089370444,0.005281859,-0.027543897,0.016631482,0.009415939,-0.09500548,0.037679072,0.05377253,0.077534094,-0.09839689,-0.01585334,0.08163479,-0.044424806,-0.064264506,0.008777779,0.017687922,0.026409421,-0.014924969,-0.021315342,0.008404831,-0.0586814,-0.11181683,0.019453743,-0.029638533,0.047130924,0.032234948,-0.07959659,-0.086055286,-0.040407095,0.022959119,-0.008621147,0.0035306597,-0.07634345,-0.005145622,0.02674829,0.0015377324,0.014862589,-0.021247031,-0.048664767,-0.05861518,-0.021773113,-0.029976243,-0.006976073,-0.07712094,0.052757688,-0.046949185,-0.048546147,-0.016094275,-0.07192243,-0.009391204,-0.034410737,0.06955362,0.0062317695,0.011058395,-0.018271867,-0.04821403,0.018549392,0.06929154,0.020907355,-0.007871958,0.080531284,0.061026897,-0.007156323,0.051483948,0.057663534,-0.0026045076,0.0060181757,0.015755912,-0.0028308288,-0.02399433,-0.05607327,0.10723468,0.0008841189,-0.015118413,-0.024818322,0.028328434,0.112008035,0.07625712,-0.11100719,-0.114995256,0.011354939,0.0691692,-0.030992411,0.014636795,-0.048771273,-0.03836832,0.016380662,-0.037120428,-0.033136602,0.0031666595,-0.007544927,0.101563044,0.034300074,-0.035369437,-0.04648584,-0.062156606,0.04982993,-0.012960675,0.0014103482,-0.004176424,-0.06795934,0.044055685,-0.06284725,6.148385e-33,0.022439264,0.054527674,-0.054780997,0.03493011,-0.057729777,-0.057007182,-0.08601554,0.06594075,-0.015053066,-0.05547204,-0.07949104,-0.053425767,0.031818938,-0.018464647,-0.025175486,-0.08918471,0.079911314,-0.03695325,0.120572835,-6.1248786e-05,-0.06800683,0.021468008,-0.06970486,-0.020745102,-0.04659605,0.013586984,0.042051457,-0.024032729,0.07185368,-0.03414508,0.09846295,-0.044699796,-0.04782252,0.029390607,0.06763889,-0.050672155,-0.0408368,-0.05812825,-0.039313596,0.018431464,-0.06571254,0.09045612,-0.032906104,0.059781004,0.09771988,-0.09680047,-0.048731912,0.035975534,0.0927499,0.019224618,-0.013052662,0.074983396,0.11207055,0.08520438,-0.08859059,-0.001311135,0.048912484,0.04890424,0.0055307485,0.034107756,-0.06513617,0.014797482,-0.019619886,-0.0013958836,-0.004370685,0.10892038,-0.13559431,-0.05105517,0.004381233,0.10695448,0.008308545,0.021894192,-0.030731648,0.058412183,-0.013785076,-0.043347698,-0.05733658,0.038993247,0.035342082,0.052512944,0.045523256,0.04177298,-0.0021742804,0.030077951,-0.09037851,-0.045731906,-0.046433624,-0.04234438,0.027507618,0.036828123,0.08171584,0.016829897,-0.06557541,-0.03430431,-0.009700862,-4.324313e-33,0.08755206,-0.03593553,0.029055255,-0.030735213,-0.07292621,0.07396124,0.01750223,-0.09777414,-0.03780029,0.0040210425,0.03383241,-0.024146019,0.015915565,-0.06779307,0.00061897025,-0.0012441094,0.012869659,0.1157588,-0.015073068,0.021816794,-0.058442876,0.11441881,0.070780404,0.05152732,0.026105909,0.015263264,0.02116948,-0.0033418857,-0.00065900956,0.06318755,0.06767913,-0.011688869,-0.056970924,-0.051790427,-0.040654223,0.015405157,-0.053179644,0.012017549,-0.02133607,0.06093521,-0.017726626,-0.015689297,0.07015143,0.040096555,0.055201065,0.018135946,-0.108337164,0.059724037,-0.063634,-0.035053793,0.015332796,0.02586535,-0.030946868,0.0058392324,0.07472985,-0.01898422,0.01920967,-0.033314724,0.058600504,-0.09111163,0.02682584,0.0035797788,-0.03964134,-0.026879821,0.067918204,0.07814658,0.038037226,0.06858861,-0.039197113,0.028070945,0.04589901,0.028144198,0.040547267,-0.018240409,0.019351788,0.0801439,0.00037682947,-0.042277683,-0.012591759,-0.051216103,-0.012065847,-0.0045908745,-0.0108170295,-0.07948974,-0.061628267,-0.04814645,0.026885461,0.04521865,-0.0047987266,0.02507898,0.030123943,-0.029021008,-0.029152976,0.06386412,0.1828634,-4.4512138e-08,-0.01076076,-0.060238756,0.012617741,-0.019897114,-0.023343846,0.012222882,0.005904248,-0.008915063,0.046640348,0.051696077,-0.07217375,0.05050022,0.06293605,-0.010512663,0.04696785,0.01901914,0.10602818,0.075260505,-0.019373912,-0.0012700073,0.007682214,-0.017867835,-0.061227158,0.04878628,0.02172959,-0.11126343,0.00880133,0.05591212,0.051749453,-0.02417223,0.07792054,0.004522099,0.018700905,-0.04467962,-0.019611252,0.0767889,-0.0025649664,-0.026951557,0.004390444,-0.017441828,-0.072597414,-0.040930826,-0.06836584,0.0058174497,-0.035257835,-0.06635744,0.008794668,0.01488062,-0.023431666,0.008692461,0.023467492,-0.051167056,0.016908897,-0.075148664,-0.06560762,-0.059383173,0.0036491628,-0.024244396,-0.020375555,-0.05407941,0.004016673,0.014740875,0.07946886,-0.035386562 +4.2.3.109,Requires Mg2+. Isolated from Pinus contorta (lodgepole pine) as cyclase I [1] and from Conocephalum conicum (liverwort) [2].,384,1.0,-0.05285376,-0.071875304,-0.080593,0.044932347,0.064903855,-0.040729504,-0.020548882,0.010174672,0.016064016,0.017687215,0.05090246,-0.03148175,0.004504797,0.0390304,-0.08694009,0.020507341,-0.0013538896,0.033353265,0.041049376,0.01132661,0.07763439,0.090042174,0.007066872,0.015252846,-0.0048429472,-0.05842103,-0.04544346,-0.0043211905,-0.00027574488,-0.059218097,-0.035365663,0.05179187,0.0869819,-0.050455693,0.025606882,0.08138094,-0.056804113,-0.021341851,0.0745377,-0.010921887,0.029162263,0.039952733,0.07310586,-0.005329357,-0.013715603,-0.01765262,0.01791161,0.0054780543,0.0592,0.018810602,-0.05371669,0.0068379752,-0.05650821,0.023284389,0.01748676,-0.008108054,-0.08962677,-0.04615574,0.060680166,0.01964527,0.0112431925,0.06681225,-0.047145825,-0.0010410411,-0.04585282,0.020222353,-0.08594298,0.013945275,0.048268236,-0.034788374,0.021810602,-0.066832714,-0.04729542,-0.035043113,-0.051718093,0.07825699,-0.008421519,-0.045232862,0.009493405,-0.009385175,-0.06416869,0.0019614052,0.010759063,0.025475059,0.02811813,0.016718043,0.053597573,0.10091921,-0.05755931,0.02555787,0.07370688,0.06666437,-0.012886579,-0.020775354,-0.012244076,0.07646345,-0.011452329,0.0048222486,-0.0377925,-0.017784454,0.035801668,-0.008536171,-0.008186793,-0.11320175,-0.109432094,-0.0006255496,-0.0032842306,0.025973381,0.035297394,0.024581714,-0.0070082517,-0.01752536,0.0013958577,-0.022024645,0.041483533,0.09268617,0.03483705,-0.080071315,-0.0066508027,0.0019266724,0.010610431,0.0025336922,0.04113774,-0.0055083707,-0.021656953,0.06628743,-0.07801706,2.6934875e-33,0.035710473,0.055504277,0.014011001,0.015917163,-0.0057631866,0.009940155,-0.084907226,-0.051425118,-0.063317664,0.0062587718,-0.11411925,-0.039841227,-0.026465535,-0.059926897,-0.025031902,0.010829175,0.03544458,-0.0074657626,0.050961602,-0.02117599,-0.0577364,0.08986984,-0.07104223,-0.010250211,0.018866977,0.06560073,0.054963827,-0.088419236,0.12509145,-0.020897824,0.098532915,-0.09513648,-0.06046152,0.023031795,0.056775235,-0.017179072,-0.053322073,-0.07508491,-0.069183186,0.03721378,0.008253953,0.04213125,0.036369022,-0.0010224595,0.06936588,-0.091827914,-0.060291182,0.040592205,-0.02696803,0.07240079,0.06003068,0.050551675,0.039491743,0.0010409118,-0.08213728,-0.017522743,0.025226848,0.0733805,0.0843627,0.049444973,-0.017485404,-0.0068518906,-0.05743593,0.009562375,0.010496711,0.030100055,-0.165483,-0.005533821,-0.121862784,0.039105777,-0.04957443,-0.15717362,-0.019129664,-0.020716354,0.03094162,0.019146154,-0.024127569,0.012597271,-0.018834354,0.024073841,-0.06591806,0.03571801,0.021155776,0.041323792,-0.04275475,-0.03645983,-0.02054096,0.007918431,0.046801534,0.08523728,0.034002066,-0.0038388977,-0.0774941,0.03903501,0.008984216,-2.4687565e-33,0.0050393688,-0.034660257,0.09408527,-0.025172504,-0.06203397,0.03453304,-0.038871787,-0.12416904,0.08033122,-0.08767444,0.051884443,0.0060542086,0.048312716,-0.041305996,-0.041484617,-0.020442097,0.074308686,0.16032077,-0.056455255,-0.0021700275,-0.01668875,0.10347653,0.03983659,-0.06798924,0.012026189,0.057124708,0.04592041,0.058357332,0.017731855,0.047265958,0.041260358,0.06674345,-0.046576075,-0.028629137,-0.09620166,0.034385733,0.017314913,-0.1277085,-0.031986106,0.043367337,-0.056778844,0.048467122,0.08293212,0.094175436,0.05016824,0.013303715,-0.0057313773,0.0021316896,-0.0049503106,0.05840554,0.025685145,0.0055081835,-0.0345315,-0.026855495,0.039349854,-0.04654933,0.038734227,0.05795725,0.04184922,-0.096322894,0.0051527754,-0.030435346,0.012664749,-0.0623101,0.053200353,0.078931056,0.038576547,0.10562585,-0.048397977,0.013567254,0.015350555,0.07057361,0.009545808,0.027040575,0.008824581,0.07799571,-0.00896831,-0.04077748,0.05501336,-0.045982204,0.011378448,0.001930579,-0.008831246,-0.026167987,0.013563786,-0.098557025,0.045006428,0.07836232,0.014011037,-0.013237397,-0.06337565,-0.0040991576,-0.0062483638,0.037486617,0.0965585,-3.0028353e-08,-0.05614503,-0.033317614,-0.055920612,-0.06794752,0.018117988,0.022887342,-0.048199084,-0.020278482,6.8270965e-05,-0.03175417,0.03333632,0.009714058,-0.01478857,-0.057927575,0.02766474,0.03070311,-0.0057554515,-0.00795443,-0.000242303,0.02897912,-0.010683051,-0.009802946,-0.088259324,0.05239243,-0.045452066,-0.13762224,0.06726765,0.04311356,0.015400958,0.023756137,0.04820859,0.028940992,-0.0097831385,-0.041887276,-0.049267728,0.014239013,-0.06856978,0.05405603,-0.014245051,-0.025030928,0.0061930264,-0.046592984,-0.03512907,-0.042619698,-0.11175431,-0.035667546,-0.0064509274,0.07144526,-0.038396545,0.034045503,0.004523364,-0.013968148,0.06342117,-0.04559996,-0.0022446301,-0.02376873,0.102778934,-0.04242266,0.0018401373,-0.085589886,-0.032289483,-0.021546755,0.08707363,-0.0087835835 +4.2.3.110,"Isolated from Salvia officinalis (sage). The recombinant enzyme gave 63% (+)-sabinene, 21% gamma-terpinene, and traces of other monoterpenoids. See EC 4.2.3.114 gamma-terpinene synthase.",384,1.0,0.011748752,-0.025698889,-0.078997225,0.038240194,0.0063971495,0.079344824,-0.03630005,0.062291328,0.056146234,-0.031140676,0.06363472,-0.008154677,0.018926525,-0.051096383,-0.0010235317,0.05025228,0.032311976,0.0035982798,0.007536565,0.040108446,0.039422195,0.0037869352,0.028575525,-0.0022464702,0.10104128,0.022049243,0.024670273,-0.008699691,0.013394169,-0.09345893,0.0511512,-0.01863313,0.01976857,-0.060916748,0.0018048376,0.0044825296,-0.051664203,-0.03022432,0.091767155,0.066296175,0.020061836,-0.035673223,-0.05999537,-0.012403538,0.0007077358,-0.10766792,-0.054960247,0.0186557,0.07732777,-0.045339085,-0.023120288,-0.08654274,-0.029770931,0.076065615,0.0074340967,-0.019262126,-0.013095811,-0.05217122,0.0013062251,0.053223964,0.048294835,0.0511004,-0.008437973,-0.07591502,-0.07787195,0.041768704,-0.030340234,-0.020563804,0.09046658,-0.095149435,-0.05470917,-0.03653137,-0.03218048,0.04737149,-0.039979864,-0.011950785,0.015518908,0.0401065,-0.027177753,-0.070663504,0.019706566,0.02996422,0.002697113,0.05571147,0.06163923,0.031915937,0.07028391,0.09620285,0.069811374,-0.0024200336,0.015949342,0.040643923,0.019208102,-0.06847683,-0.030419888,0.015708974,-0.005822099,0.009119677,0.033825,0.015735153,0.07696063,0.027538212,-0.06393825,-0.09222442,-0.08726438,0.106074706,-0.039947536,-0.057827655,0.012387235,-0.11065872,0.019562297,-0.02636398,-0.041665327,-0.012935748,-0.0431356,0.05069813,0.05136517,-0.05519978,-0.059232287,-0.045350537,0.014910561,0.01899974,0.06027707,0.010890649,0.04544337,0.09149945,-0.03191892,2.8665106e-33,0.014571011,0.036691524,-0.003923336,0.009956447,-0.0044058505,-0.015752854,-0.044846565,0.090976894,-0.03045993,-0.09622002,-0.07525355,-0.07884263,-0.03596355,0.0087965485,0.031608246,-0.047537796,0.09014857,-0.0021562853,0.082604684,-0.070452094,-0.111890495,0.046228487,-0.02418206,-0.028356804,-0.036116626,0.009883107,0.021175211,-0.012160969,0.09871816,-0.005115973,0.030323645,-0.05505868,-0.00965326,0.017362084,0.024745306,-0.0010152209,-0.06960347,-0.020538447,-0.00089360605,0.089900084,0.0038036455,0.088253394,0.05228655,0.023940878,0.009433675,-0.03846064,-0.075620145,-0.012553197,0.14127429,-0.04984495,-0.07643637,0.043104,0.042532813,0.061868064,-0.07138667,-0.008807007,0.005570967,0.050996743,0.0020543202,0.016819159,-0.022318553,0.05379443,-0.054348465,-0.039531462,-0.023701787,0.05190427,-0.102262996,0.048351146,-0.04202874,0.07427443,-0.022102712,0.06340109,0.03165609,-0.04106449,0.08519946,0.003530784,-0.046243947,0.030133668,0.036199316,-0.045713916,-0.065198906,0.018129142,0.018249597,0.05138883,-0.057477664,-0.029849695,-0.030496484,0.0020374735,-0.019138215,0.06862178,0.064027786,0.023788758,-0.09440559,-0.022592556,-0.039787415,-8.436209e-34,0.00062733854,-0.004856086,-0.015318038,-0.03557768,-0.02179079,0.104335494,-0.037334573,0.011211304,-0.046212394,0.023231927,0.041910503,-0.018954119,0.044215135,-0.090641156,0.0019412653,0.020675177,0.008675102,0.14479204,-0.059899513,-0.03830272,-0.051506557,-0.006595968,0.038965102,0.020412402,0.035291918,0.038495123,0.030814558,0.007970608,0.04270805,0.039534327,0.08183674,0.0042712633,-0.0808573,-0.076727234,-0.06703195,-0.0012244858,-0.0074529448,0.0025993735,0.016115742,0.065486774,-0.04038046,-0.0003612979,0.0018880138,0.028411483,0.09997288,0.05471087,-0.0443977,0.010691088,-0.039512806,-0.016680012,0.0967945,-0.004873215,0.046823386,-0.0075977556,0.0005666723,-0.05591137,-0.017937912,-0.0198489,0.07506019,-0.08501002,0.025006505,0.034001,-0.06430864,-0.0063384417,0.067331634,-0.007901844,0.014604773,0.07719768,-0.024317965,-0.06574888,0.079810336,-0.01138801,-0.0027801082,0.028182132,0.022222105,0.08904177,0.009016514,-0.099722154,0.044392902,-0.025504887,0.017667249,-0.036897827,-0.003071715,-0.07941564,-0.06784521,0.0027044576,0.046710845,0.01605939,0.013598004,0.02303735,-0.036397003,0.05822631,-0.09215805,0.06452548,0.17867504,-3.0476432e-08,0.073728025,-0.07660379,-0.048797335,0.0460921,0.005535717,-0.006843335,-0.0054705027,0.04039854,-0.008526561,0.04829549,-0.05023445,0.024025798,0.006100253,0.015950065,-0.00010835666,-0.008469304,0.11138714,0.06936274,-0.0020600667,0.012952839,-0.004968539,0.017621052,-0.0148933185,-0.0486733,-0.047761593,-0.15800768,0.015657721,0.046186917,0.055018894,-0.07438507,0.0633176,0.016912064,-0.03157504,-0.040885117,-0.013014915,0.058175806,-0.035749294,-0.0007023962,0.07922874,0.048025012,-0.008440568,-0.061100323,-0.07207171,0.0153432535,-0.011313377,-0.046607,0.010285671,-0.0006240905,-0.011600373,-0.055276357,-8.57335e-05,-0.019390853,0.04033984,-0.07918441,-0.10300297,-0.028931694,0.0012362469,-0.04427202,-0.02629589,-0.12694304,0.002493281,-0.0079928795,0.11082752,0.08051806 +4.2.3.111,"The enzyme has been characterized from Vitis vinifera (grape). Also forms some 1,8-cineole and traces of other monoterpenoids.",384,1.0,-0.026989244,-0.04693107,-0.10106044,-0.004826674,-0.04270117,0.07533257,-0.09321642,0.09251222,0.061213695,-0.034482718,0.06081026,-0.033291213,0.01051264,-0.008407397,-0.066725194,0.00093922816,0.0021969597,-0.0036264665,0.0006723579,-0.0627201,0.05703179,0.05574779,-0.02979376,-0.037807584,0.061257567,-0.010398711,-0.021607744,0.0036893378,0.02412713,-0.020439852,-0.05302687,0.035749808,0.008051467,-0.03506935,0.0019303801,-0.025894854,-0.020370493,-0.0791785,0.06027913,0.046894222,0.019363048,0.055683624,-0.018048717,0.031061653,-0.03779188,-0.0047218837,-0.014579933,0.059352178,0.09128366,0.011044201,-0.03242473,-0.06305514,-0.013477731,-0.0069263913,-0.010367761,-0.07290396,0.047950033,-0.065758035,-0.0016145905,0.07587538,0.0520813,-0.0029485936,0.05836185,0.030471541,-0.07312298,-0.009437629,-0.027463373,0.057651676,-0.009079193,-0.04063607,-0.110378385,-0.053325675,-0.07496236,-0.00015869245,-0.06677349,0.07776155,-0.041971426,-0.013325454,-0.02322248,0.004946176,-0.007613413,0.05489001,-0.012681688,0.07340406,0.02284421,0.07238427,0.03676002,0.027527008,0.044769388,0.071050756,-0.010807886,-0.010793641,0.003128919,-0.069422126,-0.028776683,0.02640463,0.021850353,-0.046508323,-0.010306099,-0.027959848,-0.030420717,-0.012788146,-0.015767504,-0.040336806,-0.12809116,0.09456831,-0.07825336,-0.0024436433,0.014569187,-0.030183308,-0.01790623,0.02012784,-0.006465681,-0.04648649,0.007865536,0.10636062,0.06390094,-0.021780523,0.013723957,0.009240752,0.023284895,-0.010099099,0.07772365,0.024800962,-0.05038696,0.03732958,0.0007106135,-1.0648883e-33,-0.0059336736,0.04163597,0.04252346,0.018364573,-0.0143708745,-0.016850682,-0.044186153,0.08225143,-0.08160983,-0.046435926,-0.09397676,-0.031524606,0.037413087,0.01576681,-0.0036475982,0.029784499,0.07184515,-0.041816626,0.001021198,-0.04116102,0.043310106,0.00023407456,-0.022389477,-0.01680628,-0.039195593,0.016086876,0.01717512,0.015850667,0.058410034,-0.05678292,-0.039840605,-0.048194963,-0.032156017,0.010055989,0.07120976,-0.0013216976,0.014732516,-0.02324568,-0.017016614,0.04909499,0.06148873,0.056082733,0.03244726,0.01367003,0.06372596,-0.058321353,-0.10514096,0.024468143,0.0074765706,0.010357892,-0.05437835,0.07574158,0.070963554,0.018332971,-0.09397633,0.046862517,0.09045534,0.04457214,-0.0672685,-0.008164264,0.0076890183,0.035746835,-0.06673566,0.004442177,-0.061665222,0.085364275,-0.13878588,-0.02813731,-0.011341301,0.13379717,-0.05279637,0.0020164738,-0.020251373,-0.06526618,0.09020617,-0.042864468,-0.093074694,-0.058380745,-0.029657425,0.047696542,-0.109322794,-0.007970879,0.018075038,-0.05780141,-0.03440764,-0.062140733,-0.019908339,-0.039313786,0.023166213,0.0020395634,0.06530046,-0.00022657435,-0.033388156,0.046422735,0.01972819,-1.1084257e-33,-0.02206699,-0.06662354,0.07384388,-0.034292843,-0.012376487,0.082145415,-0.06177928,-0.050846763,-0.033778965,-0.021820484,0.023068443,0.01961673,-0.033656456,-0.035448145,-0.013313804,0.050798062,0.061944585,0.08126559,-0.0031914962,-0.03179696,-0.056763045,0.029974917,0.05074548,-0.010160468,0.050991513,-0.057106692,0.049787063,0.009750844,-0.013307773,0.08200042,0.04992645,-0.05166145,-0.020765556,0.047732722,-0.015755324,0.039926678,-0.024923963,-0.039108716,0.07592018,0.08931214,-0.03166273,-0.019116787,-0.0008708077,0.094194785,0.019581676,0.038506113,-0.14548548,0.083980665,0.009031545,-0.022620413,0.07311127,0.07548474,-0.0029104403,0.06414157,0.032751217,0.03620006,0.0054161316,0.010122299,0.054162588,-0.040996972,0.037952323,-0.028566292,-0.07833191,-0.03694291,0.049236868,-0.016764252,0.023556884,0.049628213,-0.009350612,-0.049552806,0.079237364,0.05158207,-0.030705556,0.030707508,0.035227705,-0.062875405,-0.04153578,-0.10200815,-0.051534045,-0.004649293,-0.04158473,-0.033731245,0.006727379,-0.050095405,-0.015383677,-0.01776667,0.008704346,0.05936978,0.06336445,0.07388352,-0.0095181465,0.032557268,-0.085219525,0.0064592957,0.037847996,-2.529107e-08,0.07392743,-0.052595127,-0.008446102,-0.027251309,-0.034978166,-0.04252171,-0.022900257,0.0117377,0.05905945,0.025440816,-0.020155497,0.0485052,-0.014927346,0.04512335,0.07394174,0.025575243,0.054037448,0.03213991,0.0045862095,0.09624771,-0.022831438,0.012788008,-0.065320164,-0.045316152,-0.04408415,-0.13212171,-0.0403217,0.016198289,0.047361333,-0.018058907,0.014455951,0.040061377,-0.03558456,-0.09444607,-0.14249006,0.10345269,0.010567347,0.022013154,-0.01481002,0.056842234,0.04803176,-0.09642666,-0.0920521,-0.006707837,-0.025945758,0.024780167,0.046941735,-0.020069286,0.018584423,-0.035648994,-0.0038937212,0.05005265,0.055517666,0.019622311,-0.10198687,-0.02604929,0.015212211,-0.07189108,0.002127603,-0.09671214,-0.035914756,-0.032141916,0.22402517,0.045334376 +4.2.3.112,The enzyme has been characterized from Santalum album (sandalwood). Also forms some (-)-limonene and traces of other monoterpenoids. See EC 4.2.3.16 (4S)-limonene synthase.,384,0.99999994,0.0060658543,-0.08721205,-0.09642372,0.013277036,0.016924435,0.06404229,-0.06714213,-0.010053585,0.06690438,-0.06883886,0.07079059,-0.065525584,-0.07077089,0.001735562,-0.0029756068,-0.013974022,-0.036108952,0.024320837,0.00055210816,-0.012648682,0.0758784,-0.009484133,-0.035539255,0.029873343,0.055297192,0.009159887,0.019250514,-0.057326563,0.0049787406,-0.07980168,0.019592628,0.024271902,0.057624526,-0.041067492,0.021573609,-0.007870998,-0.044396695,-0.06293717,0.06524377,0.041119143,0.0809971,-0.033432458,0.015943909,-0.12686785,-0.047942393,-0.0690236,-0.02161816,-0.027151458,0.07630155,-0.041413646,0.016179377,-0.11918213,-0.013654442,0.014427292,-0.009007499,2.6325843e-05,0.029327586,-0.031493414,-0.023154046,0.07380422,0.062426593,0.057189345,-0.031564374,-0.007263535,-0.091634974,0.04587629,-0.02022648,-0.010734837,0.02228482,-0.028989827,-0.036547143,-0.09640932,-0.061998326,0.016240237,-0.030671824,0.043761496,0.02882796,-0.025066491,-0.0041199825,-0.046298973,0.07135141,0.056953784,0.0036162457,0.03944923,0.014808943,0.07426359,0.019258097,0.025045726,0.07805453,0.056929555,0.010010275,-0.018290184,-0.05755833,-0.0023041551,-0.013523317,0.041535594,0.05483531,0.038360223,0.02819409,-0.032129858,0.01498565,0.063939475,-0.055475626,-0.12510432,-0.0813507,0.07391896,-0.038617473,0.003988556,0.02134652,-0.029376745,0.021097938,-0.04606313,0.038674172,-0.043177214,-0.033869922,0.04308486,0.0049298797,-0.017209427,-0.040045656,0.059708003,0.02719916,0.031992767,0.06568602,0.054735392,0.036700107,0.040740356,-0.07357712,-8.577399e-34,0.008200223,0.0677439,0.05479832,0.0094264,0.08353815,-0.057346214,-0.06334987,0.0721474,-0.033180512,-0.09071283,-0.11846611,0.0076449327,-0.0692072,0.0075311405,-0.021276124,0.017601356,0.026527273,-0.0078945765,0.033126462,-0.05999827,-0.06748503,0.03728613,-0.066666596,-0.0074481317,0.03121205,0.010266935,0.005787407,-0.01665863,0.09909411,-0.022428539,-0.018264763,-0.07142497,-0.028381549,0.040311065,0.013883105,0.03488142,-0.04109052,-0.03532345,-0.07788169,0.014096129,0.05622861,0.031891063,-0.0066805184,0.0073930114,-0.011744718,-0.0511927,-0.1011137,0.08948676,0.14049478,0.033706617,0.024814539,0.045620583,0.05215022,0.0132069215,-0.09312794,0.017413676,-0.057923827,0.05452105,0.030539343,0.027645146,0.031391073,0.07379081,-0.04226946,-0.03788167,-0.028422846,0.11236772,-0.10627829,-0.017590776,-0.021547167,0.06428826,-0.062295433,-0.03610163,0.058572464,0.04009308,0.12029778,-0.017611733,-0.049246643,-0.021326782,0.05194122,0.0061546173,-0.15164253,0.0143803,0.05948939,0.036410574,-0.08340892,-0.045212638,0.0008407244,0.042662043,0.025701625,0.042426758,0.010365575,-0.04935303,-0.10020173,0.07828008,-0.050423946,-1.26547045e-33,0.01091431,-0.09250745,0.019311944,-0.03282243,-0.029309459,0.089257635,-0.03532501,-0.03392721,0.004821006,-0.0010388062,0.08540283,-0.020549268,0.044685107,-0.079397835,0.023748146,-0.008660712,0.022882376,0.086038336,-0.030875426,-0.008037157,-0.03860541,0.047840327,0.003753467,0.05717047,0.07454189,-0.029191451,0.047571737,0.04789677,0.00092545396,0.07023888,0.095447905,-0.019868387,-0.035755564,-0.03384935,-0.06851336,0.10599141,0.003115577,-0.028224448,0.011778564,0.06879475,-0.097308226,-0.039320774,0.00606201,0.09236521,0.09700819,-0.011535915,-0.08321849,0.058532003,0.047618724,-0.012397029,0.03815471,0.01695267,-0.041179717,0.027012276,-0.024964241,0.0226438,-0.006948582,0.00017911152,0.009792896,-0.08780034,-0.04582297,-0.058431305,-0.028073667,-0.005817042,0.029057957,-0.044863433,-0.022688437,-0.0061976467,0.033036377,-0.02546161,0.1063601,0.04865013,-0.011115875,0.07251039,-0.016270654,-0.048624977,0.026824804,-0.11321386,-0.02019624,-0.06950952,-0.007347005,-0.02155146,0.023604052,-0.006446298,-0.036794484,-0.014055926,0.06827265,0.061321467,0.019266043,0.05600306,0.009966722,0.03546705,-0.13745104,0.08344266,0.019259993,-3.318732e-08,0.09046284,-0.014826783,0.053972267,-0.012883024,-0.009324036,-0.0008747745,0.04383394,0.01839769,-0.035000283,-0.00569446,-0.0449559,0.0307422,-0.011738712,0.0073763565,0.023770722,0.031043591,0.0052422467,0.07768107,-0.04693245,-0.01906344,-0.009155218,-0.017439019,-0.08019952,-0.046612017,-0.0062025427,-0.12404077,0.01592343,0.055078585,-0.009494026,-0.04822182,0.0052286736,0.038051233,-0.022980591,-0.012765994,-0.043042175,0.03295603,-0.023692647,-0.013881714,-0.06795385,0.079333305,0.006876043,-0.09588541,-0.036634807,-0.010826027,0.0061960975,0.0075896126,0.0016607294,0.009627289,0.03316443,0.025106568,0.057611812,0.017855663,0.025145536,0.0025948018,-0.088587716,-0.025481625,-0.024566887,0.0016138838,-0.0028217044,-0.06725013,-0.036593206,-0.012900202,0.17676035,0.038258217 +4.2.3.113,"Requires Mg2+. Mn2+ is less effective and product ratio changes. Forms traces of other monoterpenoids. +",384,1.0,-0.002547263,-0.09886332,-0.0073173773,0.02602453,0.0312675,-0.044013415,-0.08556892,0.0824279,0.015869485,-0.002347679,0.06949065,0.015382893,0.03747148,-0.024608001,0.028954307,0.031999763,0.031834308,0.050478842,-0.0008992552,0.04519595,0.11171983,-0.03328007,0.019947743,-0.046574473,0.04920594,0.10389036,-0.034265097,-0.03218234,0.063207984,-0.024635477,-0.008347754,0.116102986,0.06089325,-0.11606093,-0.0027727277,0.033554804,-0.061394684,0.023151986,0.05281258,-0.044926766,0.040679418,0.028432667,0.1291315,-0.07145561,-0.045956433,-0.06894517,0.01222728,-0.03553918,0.00861689,0.019594274,-0.0016886675,-0.053811572,-0.055421468,0.008824151,0.017542126,-0.028314216,-0.09360192,0.011848464,-0.0496154,0.018074252,-0.020282494,-0.013200323,-0.025780668,-0.031507347,-0.015033025,0.024893576,-0.023435675,-0.0135596935,0.010930393,0.034569863,0.022406211,-0.012841899,-0.06982236,-0.037399333,-0.06715501,0.062419336,0.05939382,-0.0148501685,0.009785973,-0.017897246,-0.005947833,0.045973238,0.083164506,0.09146302,0.09550998,0.05395699,0.048992615,-0.0376602,-0.034194816,0.07298172,0.09873145,0.08279249,0.02925669,0.033773348,-0.044517078,0.026376175,-0.021440059,0.07684411,-0.04752311,-0.008553275,0.033329606,0.01598583,-0.09084695,-0.054287683,-0.03602742,0.0042279502,0.0073804962,-0.05362516,0.027062856,0.046684362,0.09433934,0.00082263903,-0.0291222,0.05234941,-0.03033426,0.023260424,0.06220642,-0.10432824,-0.038060945,0.013272427,0.01631857,-0.008587616,0.0073862495,0.004959062,-0.04775288,0.03698902,0.0606153,2.454753e-33,-0.038641192,0.035806764,0.041714758,0.018352332,-0.0337008,0.045153692,-0.067045875,0.030071521,0.05245159,-0.085643016,-0.119716465,-0.0013478167,-0.03137321,0.054401044,-0.030691784,-0.11100235,0.031204047,0.042124398,0.14352858,-0.040848583,-0.045578297,-0.006021993,-0.030753722,-0.061253566,-0.005083702,0.03925606,0.08033391,-0.04315485,0.04631423,-0.025899613,0.031842194,-0.08248875,-0.010566569,0.021878354,-0.016408006,0.013365597,-0.02996943,-0.057877798,-0.067666374,0.0058001103,-0.060461923,0.07119353,-0.073578455,0.02534463,0.056372896,-0.06064222,-0.03989723,0.016139166,-0.030728033,0.03182357,-0.005645703,0.08272216,0.012753585,0.053630646,-0.05817448,0.012788332,0.0047554667,0.011979413,0.0063074464,0.05859582,-0.05395208,0.06010732,0.012280074,0.037451,0.009042636,0.14028914,-0.121059686,-0.065194,-0.067577444,0.09244873,0.044066917,-0.1220251,0.053886082,0.024296658,0.063207775,0.009123522,-0.026918245,0.044609867,0.042760987,0.021867475,-0.045429848,0.0017410136,-0.022786422,-0.022938713,-0.12819266,-0.023944758,0.0074215876,-0.054671336,0.050189614,0.04475477,0.10793598,-0.013496133,-0.05422008,0.05558777,-0.03523253,-2.5384108e-33,-0.02959027,-0.047216397,0.04718329,-0.03634607,-0.094492815,0.054841157,-0.02398409,-0.1415028,0.05071531,0.014607411,0.059042066,0.005962085,-0.05563294,-0.04356352,-0.053903148,-0.04488383,0.040976726,0.12305844,0.029747415,-0.053017862,0.034944154,0.118929274,0.00527823,0.081863955,-0.011355441,0.0034794686,-0.02436054,-0.0152810635,0.051783606,0.057470053,0.015227764,-0.0008629353,-0.06607294,-0.019154921,-0.010495538,0.045696545,-0.06862242,0.0057124025,-0.0038206845,0.06947841,-0.07091149,-0.008613833,0.035488706,0.04251269,0.079471275,-0.07443049,-0.07478784,0.021184113,0.05897518,-0.0054608793,0.037503548,-0.006719034,-0.059350967,-0.064450756,0.012895997,-0.0071976613,0.011610869,-0.052582387,0.03489292,-0.062183652,-0.021224713,-0.008325623,-0.061481096,-0.080679245,0.03504344,0.04609001,0.044742063,0.022388538,0.06671609,0.019850079,0.038101014,0.047781453,0.09780598,-0.017187728,0.02681544,0.054164637,-0.013234894,-0.100397386,-0.014054126,-0.08073549,-0.06193377,0.027320497,0.01060556,-0.06300474,-0.09171624,-0.06662335,0.0051102033,0.029522937,0.0075790305,0.061006766,-0.03403394,-0.08852012,-0.050307278,0.07176547,0.036972992,-2.5660237e-08,0.0019480294,-0.055014037,0.03555789,0.02457501,-0.029392567,0.034615953,-0.0389358,-0.039658863,0.080574244,0.008676156,0.016933957,0.058910638,-0.036848962,0.050834823,0.06469497,-0.021521773,0.020376047,-0.049662177,-0.053377304,-0.027022438,-0.06346295,-0.01634011,-0.06075094,-0.015788296,-0.019791545,-0.114562236,0.005518929,0.07090846,-0.006875636,0.00037939832,0.049877565,0.0085764015,0.009949167,0.01558689,-0.017928082,0.036805518,-0.005457908,0.015311284,-0.021828264,0.04963121,-0.10561092,-0.082419984,-0.006006012,0.04389578,-0.019670127,-0.022288822,-0.014331867,0.036517978,-0.024760637,0.03126819,0.022544328,-0.022741217,-0.004973049,-0.05399086,-0.027773576,-0.018521119,-0.0070348578,0.013082913,-0.023989264,-0.070577495,-0.022358598,-0.02655667,0.073200956,0.023784887 +4.2.3.114,"Isolated from Thymus vulgaris (thyme) [1,2], Citrus limon (lemon) [3], Citrus unshiu (satsuma) [4] and Origanum vulgare (oregano) [5]. Requires Mg2+. Mn2+ less effective. The reaction involves a 1,2-hydride shift. The 5-pro-S hydrogen of geranyl diphosphate is lost. Traces of several other monoterpenoids are formed in addition to gamma-terpinene.",384,0.99999994,-0.065955,0.008948752,-0.039141845,0.001709324,0.071590066,0.09237907,-0.03715836,0.017672824,0.036504902,-0.046053804,0.14019023,-0.026127065,0.05862021,-0.087015375,0.011641931,0.02493912,0.045836568,0.011469233,-0.009862586,-0.046935108,-0.015864158,8.2423096e-05,0.051151793,-0.05435739,0.024676083,0.034779847,0.041605316,-0.00521405,0.036937706,-0.099193685,-0.027210258,0.00057713833,-0.049346406,-0.030548653,-0.030191008,0.017772669,-0.06192447,0.022396239,0.088771485,0.0042136605,0.073257916,-0.024839045,0.01641963,-0.10958101,-0.021933282,-0.044628616,-0.04521902,-0.036371708,0.04959349,-0.02236442,0.011045612,0.016223997,0.0026071055,0.0013663272,-0.07397006,-0.04853436,0.009006498,0.007599589,-0.03888387,0.055524983,0.046226777,-0.06648149,-0.018843748,-0.03346079,-0.08898233,0.04968099,-0.06943938,0.037352607,0.083204724,0.0050890697,-0.018546032,-0.03120998,-0.04699161,0.04845833,-0.06581865,0.049654935,0.04455732,-0.034987874,0.020008894,-0.0507555,-0.0058976947,0.07132798,0.011824812,0.0800996,0.021660214,0.03192337,-0.051460817,0.09572915,0.054637168,0.036534708,0.017011488,0.06909738,0.024666134,-0.063154556,-0.038450737,0.113855936,0.022850811,-0.029317794,0.015491077,0.0071497676,0.04494439,0.063216135,-0.09265576,-0.08857486,-0.05575731,0.07443755,-0.022852652,-0.06598142,0.04668793,0.0068033896,0.011832731,-0.03291831,-0.056956124,-0.030306444,-0.08566752,-0.045888275,0.07574562,-0.014379758,-0.052847516,-0.055703953,0.026039945,-0.049135502,0.009611865,0.0012021923,-0.020771254,0.020330718,-0.026052304,2.2116004e-33,0.04818065,0.012494037,-0.015348588,0.031310882,0.016424943,0.048364248,-0.01584502,0.014181937,0.00249315,-0.059700802,-0.10609385,-0.08659102,-0.06806963,0.018773291,-0.07261909,-0.04878323,0.054654717,0.06282035,0.07808319,-0.12618835,-0.027368516,0.14145704,-0.044770684,-0.032023627,0.01683391,0.014938543,0.026841253,-0.028995683,0.06949863,-0.037838228,-0.0020520973,-0.07194859,0.0037704748,0.021759132,0.045692638,-0.0051604477,-0.08690193,0.040632647,0.017692683,0.026566155,0.06274061,0.096981354,-0.025742106,0.04297163,0.023318106,-0.024450356,-0.005406625,0.01780748,0.028417304,-0.01692462,-0.026563123,0.006030239,0.041221518,0.044638738,-0.05817033,-0.028025914,0.061481982,0.032186046,0.02478471,0.030248329,-0.043166652,0.060977753,-0.012693616,0.015149551,0.030422365,0.032892134,-0.2049848,-0.0023077682,-0.062211078,0.07146887,0.057973117,-0.031229937,0.06647814,-0.004490152,0.037687056,0.009986891,-0.021550344,-0.054731984,0.042455688,0.021523928,-0.013236296,0.02320727,0.04005826,0.04774516,-0.06585984,-0.0019652362,-0.057677984,-0.02658226,0.05092104,-0.0002806077,0.034488387,0.010226403,-0.04690111,0.0077801286,-0.033297006,-2.292802e-33,-0.014740485,0.02415747,0.060112454,-0.029368317,-0.002234827,0.04715005,-0.038732924,0.027644502,-0.041605275,0.043544013,0.042625226,-0.0077587515,0.022636194,-0.020542191,-0.022698691,0.025718594,0.09849776,0.1876318,-0.093280375,-0.029294826,-0.06670511,0.0603997,0.048140716,0.061687768,0.050859556,0.020993544,0.06619695,1.4672628e-05,-0.023006797,0.093933694,0.08347076,-0.024556847,-0.042228073,-0.0010761668,0.060139712,-0.01062338,-0.022433562,-0.014056656,-0.023399085,0.02899182,-0.031742055,-0.0782425,0.029367525,0.061574772,0.07420187,0.02350734,-0.0809528,0.0061629843,-0.05048607,0.027664041,-0.005436039,-0.037844025,-0.03340736,0.0020521493,0.051432163,-0.06571537,0.024560232,-0.019652996,0.03718869,-0.097867176,0.022707993,-0.02172659,-0.052410305,-0.016773928,0.027633836,0.07688742,0.03186103,0.04867571,0.0054655904,-0.033160657,0.06810426,0.061313964,0.033678476,-0.051398475,0.04466715,0.06028109,0.0361238,-0.05914786,0.022154529,-0.036731545,0.0053145937,-0.047446173,-0.05371852,-0.11332952,-0.033147044,0.002736008,-0.004221124,0.08502569,0.011265069,0.0762804,-0.04231469,0.050413575,-0.071357705,0.13413227,0.08771901,-4.1871978e-08,0.02728383,-0.07786251,0.034702938,0.055245068,-0.051479004,0.010159173,-0.03797633,-0.0737438,0.06815805,0.014965755,-0.015782494,-0.0075618434,-0.0021426692,0.023943016,0.00862716,-0.044831377,0.0692165,0.07487688,-0.046211936,-0.034909964,-0.042250816,0.035016295,-0.02266671,-0.046512164,0.004993732,-0.122150704,-0.04495408,-0.014427886,0.052853916,-0.11955225,0.0417685,-0.009970178,-0.06597169,0.008747574,0.008156212,0.047856826,-0.011603975,0.051662035,0.017624518,0.013387373,-0.08163479,-0.03176937,-0.054997258,0.041427687,-0.08712632,-0.039162677,0.0012657921,0.035298362,-0.0491503,-0.02392354,-0.021995174,-0.037246197,0.021141477,-0.077483036,-0.079962544,-0.033503864,-0.0010255005,0.01464429,-0.016198039,-0.08857874,-0.080552764,-0.0026185082,0.076689504,0.071470864 +4.2.3.115,"The enzyme has been characterized from Dysphania ambrosioides (American wormseed). Requires Mg2+. Mn2+ is less effective. The enzyme will also use (3R)-linalyl diphosphate. The reaction involves a 1,2-hydride shift. The 1-pro-S hydrogen of geranyl diphosphate is lost.",384,1.0,-0.05846934,-0.010328537,-0.03241908,-0.03395738,0.023561463,-0.069499105,-0.045295216,0.029996434,-0.008361894,0.03615531,-0.0060937675,-0.05176347,0.061345022,-0.019539554,-0.052182127,0.030905733,-0.02680239,-0.01562721,0.026834857,-0.016679099,0.09337477,0.048533477,0.0025233773,-0.030126011,0.07077353,-0.009810814,0.062168844,-0.011105827,-0.004278537,-0.066240124,0.01709679,-0.034981336,0.034822524,-0.12978253,0.04186159,0.10549286,-0.0687535,-0.02612552,-0.0055169608,0.029400943,0.04084213,0.02437704,0.060311366,-0.015815966,-0.09841459,-0.041749667,0.008701766,0.020934198,0.049424272,0.0055814893,-0.07187933,-0.092228144,-0.0049761315,0.006398066,0.0046832277,-0.032363016,-0.08994307,0.07769824,-0.026516302,-0.08034655,0.008198919,0.011853978,0.010186671,-0.01878492,0.020198716,-0.017631069,-0.014259685,-0.092107505,0.043235794,-0.035782877,-0.043791782,-0.036498796,-0.030235535,0.0015349276,-0.0286247,-0.026192605,0.05048035,-0.044351425,0.12877035,-0.0093856715,-0.035921693,-0.0194911,0.06521982,0.067016535,0.060672257,0.11049244,-0.024401138,0.05077695,0.023783265,0.014211795,0.031631716,-0.014649297,-0.008089601,0.0008245731,-0.05260397,0.10427974,-0.010215407,0.03949886,0.04206661,0.03036218,0.03150624,0.029524762,-0.08832846,-0.05325975,-0.07379854,-0.008837463,0.03429536,0.06905545,0.010659374,0.048398968,0.05921242,0.0015616443,0.06119646,0.06444454,-0.05801218,0.06274634,0.05653809,-0.04036097,-0.0064359987,-0.07769558,0.030567825,-0.04363772,0.019538749,-0.01386596,-0.0019862037,0.071864,-0.10178971,3.573749e-33,0.0031137522,-0.015115014,-0.041958056,0.015474728,-0.028462695,-0.01311814,-0.06269001,0.0005981308,-0.04622876,-0.052553266,-0.09721386,-0.12057066,0.035151877,0.01611138,-0.078475624,-0.07874863,0.05897884,0.0142997755,0.09387736,-0.002768961,0.026480796,0.07083123,-0.015492402,0.039513808,0.02622182,0.057234664,-0.009167945,-0.0042018434,0.09587926,0.021053875,0.030386912,-0.16282684,-0.07564502,0.034924023,-0.013066367,0.021180272,-0.06700477,-0.037249926,-0.039031375,-0.0031957892,-0.03806949,0.03466188,-0.05011459,-0.050885994,0.057449285,-0.05230871,0.027647343,0.11320247,0.014740539,0.033572637,0.11215105,0.010948975,0.10136589,-0.06216943,-0.10206798,0.06939002,0.0013160117,0.039651453,0.11028558,0.055768885,-0.0147700105,0.07825149,0.05505022,0.038252838,0.14643833,0.017833574,-0.037305634,-0.03722455,-0.052345827,0.10721598,0.032201473,-0.08731128,0.013490648,0.064192094,-0.02876031,-0.011150778,-0.01706321,-0.06670361,0.046131223,-0.030597499,0.045804203,-0.03529521,0.046847634,-0.0071401806,-0.06439968,0.014897798,-0.033445183,-0.050398726,0.013705945,0.10336324,0.049753435,-0.041386917,-0.06191078,0.051644865,-0.024399508,-2.9774332e-33,-0.03821193,0.013987794,0.018009968,-0.05041543,-0.07076084,0.081335396,0.08270254,-0.0034868661,0.054210614,-0.023778776,0.088919766,-0.018905818,-0.03866317,-0.02983383,-0.044557557,0.03723178,0.016954536,0.052819632,0.018666288,-0.024734879,-0.02062536,0.114652365,-0.032420103,0.040340956,0.026227744,0.016382024,0.059502702,0.07101005,-0.038457803,0.034236852,0.011558399,0.03297251,-0.0321428,-0.04163938,-0.03105,0.08858122,-0.07197421,-0.047857028,0.01581789,0.005230059,-0.0191552,-0.0038825693,0.07891335,0.07051254,0.0032638113,0.016896423,-0.061331447,0.047891077,0.046266336,-0.016013559,-0.053291436,-0.0012990675,0.026374012,0.0056302277,0.017008703,0.03370757,0.020360192,0.03056016,0.014955631,-0.08176749,-0.07353639,-0.038712785,0.008824489,0.024694288,0.08811054,0.0735603,-0.041168053,-0.014402637,-0.030742092,-0.007740446,0.116891794,0.01615546,0.033908427,-0.010360886,-0.034997173,-0.022887167,-0.033489704,-0.0045723654,0.050576285,-0.041967914,0.05990286,0.02631099,0.004800685,-0.041240245,-0.0136182625,-0.07951143,-0.022208873,0.09955087,0.0035335175,0.020206563,-0.019456435,-0.024416607,-0.06948612,0.006975513,0.10068552,-3.9915e-08,0.0056201797,-0.08338851,0.027070021,-0.024245398,-0.029368827,0.040499963,-0.028814675,-0.0015084806,0.02301326,0.014132421,-0.008173904,0.024508473,0.003150257,-0.044876043,0.011451495,0.000326187,0.021406708,0.08157844,-0.08525274,-0.08682477,-0.026850337,-0.015852923,-0.07179075,0.026406143,0.008943146,-0.06393149,-0.0009431953,0.022165323,0.025641667,-0.08615365,-0.05809946,0.025363078,0.010794591,-0.06367542,-0.10224582,0.03884381,-0.08067526,0.03708543,0.03301764,0.034282066,-0.019713454,-0.007844283,0.017646216,0.014369905,-0.1092188,0.004057417,-0.077502154,0.0631893,-0.044357438,-7.428447e-05,0.06936309,-0.060556997,0.012564171,-0.047171526,-0.05836185,-0.023116075,-0.023141,-0.011944962,-0.05715234,-0.03707001,0.0034119012,0.0654289,0.11023987,-0.06974765 +4.2.3.116,Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-camphene and (+)-alpha-pinene. (3R)-Linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. Requires Mg2+ (preferred to Mn2+). See also EC 4.2.3.121 (+)-alpha-pinene synthase.,384,1.0,-0.018789263,-0.05763155,-0.048424825,0.039914876,0.085369445,0.044862606,-0.010837553,0.045442518,0.047046676,-0.011481083,-0.008213036,0.027902154,0.012741225,0.037272487,-0.041639753,0.023098527,-0.046531938,0.101862386,-0.009064576,0.00030289154,0.11258976,0.0011131238,-0.008228793,0.038229927,0.098917335,-0.05766446,-0.009827148,-0.004860088,0.0035540997,-0.056148577,0.06333485,-0.006245661,0.102908164,-0.10049041,0.018593388,0.038754698,-0.060934797,-0.088181846,0.018665554,0.066041745,0.04375462,-0.0076156342,-0.0059530316,-0.002687053,-0.007000142,-0.059159,0.013072356,0.020823088,0.08468915,-0.016789472,-0.0874575,-0.13069086,-0.0719445,0.029006355,0.0030171047,-0.0026253914,-0.0911836,-0.022867607,-0.0017848848,-0.012038958,-0.016301855,0.024098698,-0.04908623,-0.07868974,-0.012598148,-0.0058577787,-0.015644958,-0.061970755,0.016347235,-0.04688138,-0.045281757,-0.053438056,-0.08227491,0.04047613,-0.017456291,0.02365161,-0.006813853,0.028466318,-0.012432708,-0.05295035,0.0047675073,0.035668693,-0.010485501,0.020526966,0.08012679,0.09006959,0.052800618,0.055386856,0.08221867,0.016483355,0.0435854,0.011800623,-0.06139192,-0.027737536,-0.03560917,0.02779437,0.01886482,0.032702386,-0.0048957434,0.009183294,0.072412275,0.021564528,-0.0472066,-0.12024063,-0.05891323,0.07206758,-0.01891601,-0.005570649,-0.022861019,-0.027108911,-0.01923932,0.001336773,-0.01820621,0.00015244217,0.0016887182,0.095869355,0.055381127,-0.047268283,-0.04980121,0.0052303495,0.03666993,-0.034370985,0.037762333,0.071883924,-0.023185968,0.09264383,-0.05545305,4.22054e-33,-0.008453651,0.08452988,-0.012210273,0.013925344,-0.046394177,0.014995771,-0.08270202,0.021384558,-0.0061303605,-0.05890892,-0.0800622,-0.040868144,0.0106675485,-0.069455355,0.03261264,-0.052173536,0.07669442,-0.047686607,0.07230734,0.0011289296,-0.1006636,0.013250057,-0.06316039,0.021071766,-0.003670103,0.045168858,0.0704142,-0.01931623,0.11012711,-0.02925189,0.11006856,-0.05943278,-0.07783259,0.037092205,0.0286887,-0.058276094,-0.0681288,-0.07207576,0.020817988,0.072948575,-0.06226711,0.021544449,0.023194859,0.0388618,0.05276048,-0.108129725,-0.081666775,0.06342904,0.081084296,0.00129534,0.0132409185,0.06183724,0.06838814,0.013782658,-0.11023841,0.0080210315,0.0012355357,0.078850225,0.021313658,0.05203177,-0.060051195,-0.004729832,0.016051173,-0.047024235,-0.0370218,0.06180586,-0.10681091,-0.012001338,-0.035857856,0.05848237,0.009681126,-0.048417766,-0.014267892,0.06844542,0.009822795,-0.044461355,-0.029399622,0.060104944,0.058501266,-0.024773141,-0.036087763,0.05235898,0.006105938,0.08825401,-0.08447,-0.069482945,-0.015168411,-0.029531125,0.01194142,0.05131063,0.0724406,-0.0076995934,-0.07566163,0.008503326,-0.021219462,-2.5730398e-33,0.043489,-0.06964338,0.010682956,-0.033016905,-0.08285658,0.035076413,0.0013779503,-0.105715506,0.02807968,-0.0030516803,0.027567334,-0.060264796,0.007599774,-0.07311443,-0.015241196,0.02615772,0.00554956,0.120476454,-0.02059225,0.04016536,-0.008540385,0.06596154,0.05357158,0.030388016,0.029230151,0.024043856,-0.008790553,0.057115104,0.06510085,0.032168914,0.07677922,-0.010662845,-0.05599329,-0.11256991,-0.07221728,0.0349635,0.07096735,-0.010725352,-0.012964705,0.066706926,-0.013170058,-0.012886866,0.075734615,0.06652994,0.07805935,0.06064667,-0.03239039,0.024482157,-0.05949437,-0.028173266,0.03682118,-0.024118263,-0.021123674,0.025305742,0.028857484,-0.036948662,0.046637762,-0.013686717,0.04431033,-0.109360166,-0.00841562,0.00022914784,-0.04327897,-0.007913878,0.04057244,0.009108582,0.03160521,0.03652229,-0.015101881,-0.014196246,0.051494684,-0.0031835982,0.035013013,0.039751906,-0.0631185,0.032723278,0.02868864,-0.017268345,0.04559425,-0.09108223,-0.012014409,-0.01910845,-0.038432505,-0.07405957,-0.04981132,-0.016662594,0.07700986,0.093132496,-0.029240265,-0.002904998,-0.007584389,0.026168544,-0.018111307,0.10053758,0.14993937,-3.990177e-08,0.046999503,-0.124795355,-0.04117723,-0.052461095,-0.00629897,-0.03789097,-0.01627612,0.014010958,0.0018752408,0.006549662,-0.044257376,0.032121994,0.066821076,-0.05217445,0.04659767,0.052752677,0.08562873,0.081352346,-0.018430801,0.019838164,0.017637141,0.021273747,-0.056319475,0.023507161,0.010248902,-0.13410814,0.04532445,0.08940932,0.0011898866,-0.013965779,0.070441104,0.0112059545,0.034013364,-0.04114996,-0.008300898,0.082193166,-0.047419164,0.01010826,0.06201296,0.02466033,-0.058920488,-0.09612801,-0.026104186,-0.016690878,0.015484974,-0.057303216,-0.0016580875,-0.03189471,0.02777033,-0.037696358,0.01478312,-0.046123955,0.025620578,-0.06638125,-0.0495936,-0.005705617,0.022939958,-0.07320355,0.035498857,-0.08867051,-0.013933702,0.020836031,0.06888095,-0.024659136 +4.2.3.117,"(-)-Camphene is the major product in Abies grandis (grand fir) with traces of other monoterpenoids [1]. In Pseudotsuga menziesii (Douglas-fir) there are about equal parts of (-)-camphene and (-)-alpha-pinene with traces of four other monoterpenoids [2,3]. In Solanum lycopersicum (tomato) tricyclene, beta-myrcene, limonene, and traces of several other monoterpenoids are also formed [4]. See also EC 4.2.3.15 myrcene synthase, EC 4.2.3.16 (4S)-limonene synthase, EC 4.2.3.119 (-)-alpha-pinene synthase and EC 4.2.3.105 tricyclene synthase.",384,1.0,-0.022470575,-0.055703714,-0.059150178,0.0103370175,0.044387117,0.017529238,0.024654906,0.022993093,0.040498517,-0.02056932,0.06899264,-0.05353452,-0.04130293,0.016193837,-0.041072067,-0.0058262544,-0.07169411,0.041762054,-0.015297284,0.022335462,0.021847874,0.026733026,-0.029188232,0.0624421,0.018522484,-0.04384409,-0.032069918,-0.009051965,0.029230464,-0.051618356,-0.03073619,0.06701888,0.015932037,0.04644626,-0.03162181,-0.020235134,-0.020100648,-0.042552073,0.08307331,0.0410609,0.09957661,-0.013558846,0.04855745,-0.06783188,-0.021563563,0.004327281,-0.09920479,0.009158349,-0.0010896189,-0.050627373,0.00608967,-0.062275123,-0.040229138,0.059725203,0.01580529,-0.028635642,0.025153652,0.004424559,-0.015435368,0.0897253,0.04361142,0.013414561,-0.020867521,-0.035628468,-0.11460929,0.026705706,-0.09242402,-0.0060825422,0.011471636,-0.021810021,-0.009082796,-0.10294141,-0.11552256,-0.024708604,-0.033756882,0.09087031,0.022174839,0.04129263,-0.07062089,-0.08215166,0.0060059796,0.037541598,0.049160484,0.06364477,0.0030116017,0.047093578,0.020299716,0.023536105,0.029570997,0.055761565,0.052856065,0.01663887,-0.025520269,0.023769032,-0.070538945,0.07882544,0.12510005,0.004606028,-0.003566669,-0.027603693,-0.013995245,-0.03940032,-0.05618914,-0.08804252,-0.13637175,0.0391144,0.036149304,-0.044618204,0.05764654,-0.029967349,-0.017792407,-0.0031112665,-0.01369031,-0.01586414,-0.0746168,0.038027607,0.034735866,0.008807868,0.028756768,0.048413303,-0.0049689645,0.07919079,0.08203411,0.049995605,0.000319121,0.027913608,-0.04414214,2.9824681e-33,0.008004088,0.11470402,-0.007222135,0.023769433,-0.016813118,-0.012656362,-0.08467849,0.023294326,-0.00074667303,-0.0770656,-0.1159656,0.009670463,-0.05018817,0.0011168709,0.01164361,-0.014213336,-0.010975999,-0.03825603,0.03148355,-0.06522003,-0.101769984,-0.008633827,-0.10498237,-0.0057012215,0.045891453,-0.014383272,0.04700673,-0.042223994,0.059866413,-0.03818651,-0.023179302,-0.020497492,-0.012398285,0.040418703,0.02489073,-0.014156117,-0.045157295,-0.06250876,-0.06789739,0.05594124,0.0027238808,0.036470063,0.00070517935,0.010849406,0.050899167,-0.051355947,-0.062445384,0.09099221,0.06511559,-0.00630072,-0.049595926,0.04619663,0.034059342,0.03460283,-0.11849596,0.028379958,-0.0029668133,0.024309821,0.06880295,0.084700085,0.03136906,0.054977905,-0.03536332,-0.05259146,-0.04682613,0.14143617,-0.13631766,-0.0528056,-0.037961405,0.02415756,0.020543119,-0.071382284,0.0973189,0.023429742,0.12024814,0.043352056,0.013505823,0.029532664,-0.012742716,-0.0032914025,-0.09898202,0.017119134,0.029290667,0.013624434,-0.08245912,-0.05689238,0.044643145,0.0051367367,0.048763383,0.047229342,0.055723507,0.020192519,-0.053421915,-0.012974391,-0.036811553,-2.2236509e-33,-0.003955423,-0.009250655,0.028833337,-0.09017356,0.006998697,-0.01827992,-0.091975205,-0.1399363,0.0333901,-0.043256767,0.076700725,-0.013072133,0.016380657,-0.056751277,-0.02628985,0.029037882,0.044096,0.09046772,0.025800165,-0.0024347655,0.018515306,0.06499583,-0.0464013,0.026148448,0.017368417,-0.06388034,0.03355818,0.06493345,0.051599186,0.05457589,0.067151174,-0.050245024,-0.028909994,0.013676333,0.023379123,0.060329873,-0.006026473,0.010234363,0.006041801,0.03961432,-0.07489667,-0.07000989,0.002760037,0.12671386,0.13249227,0.0058213663,-0.09407636,0.04162012,-0.034416463,0.013273767,0.013431393,-0.024072934,-0.024275945,-0.019230708,0.009430679,-0.03858411,0.07128249,-0.011522485,0.007159357,-0.07825408,0.07240058,-0.010021261,-0.020616187,-0.023475805,0.01233025,-0.03160492,-0.045747202,0.017395398,0.031073779,0.0074893134,0.06767283,-0.020460142,0.0001980027,0.040554386,-0.048901275,0.016958583,0.06256241,-0.07236407,-0.009761414,-0.06780965,-0.03223007,0.028538765,0.004311132,-0.03751255,-0.040291067,0.015503188,0.054029312,0.059604306,-0.035074852,0.01772581,-0.00841509,0.0795136,-0.034412853,0.1299033,0.07395487,-4.3195143e-08,0.06596082,-0.03435891,0.0065807947,0.0061763297,-0.007006654,-0.07232495,0.04715572,0.014763454,0.0023869667,-0.043767247,-0.06322389,0.021000613,0.018138481,-0.016677624,0.08377641,0.011305482,-0.014599469,0.023979725,-0.01186235,0.04566306,0.040234752,0.005076441,-0.057887286,-0.07115517,-0.07435597,-0.1201352,0.04926687,0.043125406,-0.014815952,-0.023540914,0.1133287,0.035152197,0.013146078,-0.010968676,0.012981092,0.052581925,-0.050991084,0.034425292,-0.010423625,0.029706327,-0.022487335,-0.09281066,-0.004564696,0.014662485,0.0102480035,-0.045803625,0.02299343,-0.043770466,0.10113068,-0.0018968522,0.062237207,0.0037705705,0.06695547,0.0036543394,-0.028272763,-0.01715728,-0.015419331,0.05447928,0.039287966,-0.094151825,-0.069792904,0.01671054,0.14828905,0.059335183 +4.2.3.118,"The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms.",384,1.0,0.074825265,-0.008050845,0.03321265,-0.010169819,0.09877108,-0.041698936,-0.030580007,0.031056808,0.049665153,-0.04187502,0.061984785,-0.08207331,-0.024878753,-0.011539969,-0.03639046,0.14131264,-0.023005797,-0.013386048,0.058587685,0.055324275,0.07994395,0.13609867,0.01678009,-0.05510356,-0.13048309,0.06246404,-0.010348825,0.024406923,0.037609097,-0.06606174,0.10576112,0.09699522,0.022333426,-0.06164961,0.0046570273,0.023961704,0.008875439,-0.021915855,-0.0038840256,0.027553502,0.01932058,-0.097945146,-0.0025086803,-0.01036006,-0.10037612,-0.044074126,0.033844113,-0.017730467,0.05992127,-0.021256914,-0.011392518,-0.028127441,-0.02067376,0.007760745,0.015770424,-0.006802819,-0.045469176,-0.031077202,-0.07865903,-0.06042549,0.059870068,0.015520532,-0.0601375,-0.025101563,0.031475786,0.01855984,-0.02396202,-0.08387312,0.06064309,-0.030868512,-0.08690604,-0.031263888,0.008652664,0.026536658,-0.026931962,0.04442946,0.027191678,-0.06860601,0.10402847,-0.119526915,-0.006625475,0.05721842,0.019968567,0.0017473713,0.014874649,0.0057830983,-0.030122556,-0.035914276,0.039830096,0.02755419,0.03783069,-0.01717951,0.013815178,-0.023070997,0.008618991,0.032329705,0.04311465,0.044133227,-0.011821333,0.0531263,-0.023927256,0.0116151,-0.15223563,-0.11155341,-0.022096323,-0.021293914,-0.06386395,-0.07158255,0.018333867,0.017320426,-0.042367622,-0.025182575,-0.036199834,-0.07433827,-0.054263268,0.032215584,0.08652906,0.03552151,-0.0631724,-0.035154026,-0.025639353,-0.013498675,0.0025486804,-0.010697891,0.042979512,-0.11045608,0.016603654,-7.992806e-34,-0.030874694,0.022560794,-0.017361047,-0.0054895366,0.03516233,-0.02288133,-0.022729892,-0.0010637017,0.0010098538,0.017244995,-0.0395838,-0.0475722,-0.09323248,0.07912761,0.06922623,0.012240687,-0.0062530343,-0.0033304107,0.13176933,-0.08203291,-0.049515333,0.08965205,0.013369237,-0.02960357,-0.06381865,-0.0116106,0.057769585,0.012698931,0.05056357,0.006330973,0.093315184,-0.0040155402,-0.06408319,-0.02769606,-0.046746366,0.022451537,-0.082304515,-0.0062350007,-0.021185419,0.031438287,0.024720902,0.016143803,0.043659873,-0.0005519232,0.0023115452,-0.031251725,-0.060065456,0.016998641,0.118337154,-0.025667086,0.021563552,0.010889145,0.00988207,0.04729317,-0.03169659,-0.031627562,0.008043171,-0.014508032,0.0050897,0.045867328,-0.058241937,0.088969454,0.044705473,0.04391628,-0.051063515,-0.11986826,-0.035049185,0.021279773,0.04626075,0.044573266,0.031172434,-0.012050838,0.0441246,-0.041037988,-0.029130833,-0.03690695,-0.023353396,-0.019101353,0.083926745,0.006294253,-0.08908164,-0.06851511,0.011487604,0.013955297,-0.12746985,0.03964449,-0.061247986,0.0042790133,-0.007385425,0.06330052,-0.027544722,-0.048163295,-0.049306866,0.029928567,-0.0014353961,-2.0138172e-33,-0.022161325,-0.051031686,0.034499824,0.015255842,-0.0062745535,0.043537386,-0.032068565,0.039708447,-0.087566055,0.062167354,0.051657055,0.08386958,0.07200626,-0.003620016,0.042017423,0.04283403,0.06735103,0.048831288,-0.0056651565,-0.011925402,0.035242125,-0.0024339943,-0.038438912,0.023960952,-0.030112,0.054789852,0.10871439,-0.0380581,-0.0041161682,0.021977797,0.05394962,0.0694894,0.004579426,-0.035404332,0.041196357,-0.009093007,-0.025859596,-0.08970054,-0.08090641,0.038877077,-0.023868011,0.005230091,-0.013195659,0.020125166,-8.987604e-05,0.008938799,-0.0035531537,-0.07368241,0.09756664,-0.039592713,0.059370156,0.069801465,-0.030116832,0.042179853,-0.02263372,0.029493883,-0.07639256,-0.037689533,0.044326972,0.015250275,0.0032933657,0.014539293,-0.07855072,-0.059695315,0.04987883,0.044998407,0.002627425,-0.0062251138,0.025397591,0.034357797,0.02814711,0.042157933,0.010705794,-0.009148807,-0.04281436,-0.048565704,-0.010298456,-0.07261469,-0.050042767,0.0065312553,0.016275225,-0.08521144,0.046444606,0.021968082,-0.0345245,-0.12230786,0.01380616,0.07212313,-0.035495725,0.050431386,0.0327511,0.07586649,-0.12477558,0.050125986,0.0717592,-3.2144815e-08,-0.053319782,-0.17907609,0.05804682,-0.05282341,-0.033072803,0.028976738,-0.027942741,0.04342037,-0.008796814,0.018227903,-0.020143222,0.03483436,-0.0256873,0.051840167,0.09992561,0.026953569,-0.014837321,-0.070721686,-0.04620225,-0.097953506,-0.06369281,0.045323186,0.008675037,-0.05219317,-0.030120904,-0.029503848,0.008642497,0.03489119,0.016397307,0.029298015,0.10344128,0.06695286,-0.04531674,0.015777523,-0.07129021,0.05610448,0.021990089,-0.07703123,-0.04162053,-0.014495489,-0.024621755,0.02287919,-0.037235938,0.045006387,0.023129724,-0.078870356,-0.053319566,0.07889753,-0.036432594,-0.041345414,0.0022700408,0.033864275,-0.02363816,0.06140594,-0.022756472,-0.035237703,-0.06624304,-0.04933617,0.027270282,0.0003862084,0.07928828,-0.009140255,0.08093752,-0.062164325 +4.2.3.119,"Cyclase II of Salvia officinalis (sage) gives about equal parts (-)-alpha-pinene, (-)-beta-pinene and (-)-camphene, plus traces of other monoterpenoids. (3S)-Linalyl diphosphate can also be used by the enzyme in preference to (3R)-linalyl diphosphate. The 4-pro-S-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+) [1-6]. The enzyme from Abies grandis (grand fir) gives roughly equal parts (-)-alpha-pinene and (-)-beta-pinene. However the clone ag11 gave 35% (-)-limonene, 24% (-)-alpha-pinene and 20% (-)-beta-phellandrene. It requires Mn2+ and K+ (Mg2+ is ineffective) [7-10]. Synthase I from Pinus taeda (loblolly pine) produces (-)-alpha-pinene with traces of (-)-beta-pinene and requires Mn2+ (preferred to Mg2+) [11,12]. The enzyme from Picea sitchensis (Sika spruce) forms 70% (-)-alpha-pinene and 30% (-)-beta-pinene [13]. The recombinant PmeTPS1 enzyme from Pseudotsuga menziesii (Douglas fir) gave roughly equal proportions of (-)-alpha-pinene and (-)-camphene plus traces of other monoterpenoids [14]. See also EC 4.2.3.120, (-)-beta-pinene synthase; EC 4.2.3.117, (-)-camphene synthase; EC 4.2.3.16, (-)-limonene synthase; and EC 4.2.3.52, (-)-beta-phellandrene synthase.",384,1.0,-0.026621578,-0.07701663,-0.04029144,0.016823161,0.08412722,0.021572072,0.0022462416,0.030640807,0.04742103,-0.004956339,0.009674894,0.06188082,0.016019393,0.0354341,-0.04731261,0.034425404,-0.0278924,0.04219716,-0.044449497,0.043787826,0.12510681,-0.051250264,-0.025704699,0.033778418,0.06579749,-0.06931197,-0.00823188,-0.0144881895,-0.028017817,-0.051947277,0.05297168,0.019221138,0.10033539,-0.05948021,-0.0043905233,0.030560309,-0.046555847,-0.043503046,0.01905787,0.052842144,0.054160424,0.015581247,-0.0035479192,-0.033653893,-0.017960252,-0.035520777,0.015602417,-0.018944733,0.053120233,-0.003375249,-0.042809855,-0.12294406,-0.04048617,0.012521413,-0.0034964595,-0.017975911,-0.07224572,-0.056294087,0.0012612209,-0.010465925,-0.011493234,0.030522022,-0.063896395,-0.057568252,-0.030696949,-0.016577166,-0.056535706,-0.049551316,0.0052360473,-0.037970852,-0.029427921,-0.0640015,-0.09012862,0.001859828,-0.00998366,0.032811046,0.032977205,0.03692923,-0.0028915391,-0.07608901,-0.0019769063,0.045685597,-0.010813919,0.010265826,0.051658522,0.10160504,0.030315466,0.09354668,0.042139623,-0.0005992558,0.08794902,0.027168848,-0.036703423,-0.030358065,0.009208879,0.069650546,0.02485797,-0.0064175166,-0.022825636,0.0056171217,0.028754417,0.018533748,-0.037474014,-0.15742145,-0.06489774,0.06459765,-0.0087857945,0.03687656,0.014795832,-0.003675643,-0.009226335,-0.025950171,-0.0069120163,0.05922826,-0.014132268,0.107856125,0.060671438,-0.0356106,-0.061208136,0.0030766346,0.028903304,-0.00585182,0.043808833,0.08295127,0.004305492,0.08480834,-0.042213954,2.5890393e-33,0.031056918,0.0804709,-0.032696247,-0.017827373,-0.04702753,0.018522458,-0.07008679,0.022405228,0.011305638,-0.033412214,-0.12263432,-0.041600756,0.010069091,-0.06463038,-0.0039008923,-0.016934844,0.08434355,-0.038403746,0.0741061,-0.00671689,-0.078232065,0.019289697,-0.08461147,-0.011212128,-0.0054689352,0.04388826,0.06551637,-0.021017289,0.10250193,-0.028646095,0.06201806,-0.08179918,-0.05593138,0.03896915,0.022930503,-0.076412074,-0.06817494,-0.05528777,0.0034308261,0.016455784,-0.049937703,0.032509867,0.0013382627,0.065071344,0.068453416,-0.09097164,-0.041373007,0.04997068,0.03701348,0.029244488,0.021658204,0.03998519,0.06687761,0.005430275,-0.14631157,0.036236323,-0.018393237,0.0544811,0.06382903,0.064514756,-0.012838673,0.0018160704,0.011992844,-0.030624762,-0.013331653,0.08490502,-0.1330275,-0.011580188,-0.06660638,0.09843503,0.013324777,-0.10150042,0.01646317,0.040569287,0.043261584,-0.0006881042,0.02928611,0.041469827,0.052400984,-0.012245462,-0.065072075,0.070617355,-0.018885236,0.07495793,-0.083561614,-0.07174321,0.006895193,-0.038531713,0.007229482,0.0859354,0.07602912,-0.03375125,-0.09143444,0.010384583,-0.02335069,-1.2281633e-33,0.04061866,-0.061566114,0.025889494,-0.061948664,-0.06387962,0.040390626,0.009427625,-0.12536651,0.004137126,-0.045918226,0.037808135,-0.02014992,-0.014788875,-0.04008066,-0.050040368,0.029764902,0.018044062,0.14893249,-0.03546014,0.03042949,0.011477595,0.10616247,0.031879276,0.03330332,0.018743364,-0.006768972,0.017478997,0.068648994,0.072153695,0.06316583,0.09920606,-0.028853718,-0.082198255,-0.08335933,-0.059215512,0.042125788,0.049901403,-0.013540244,-0.009606624,0.04648956,-0.03298862,-0.0543473,0.022212543,0.06060599,0.115690246,0.033195734,-0.050360344,-0.0032864397,-0.005817815,-0.015386829,0.035065312,-0.0070931083,-0.0041196626,0.03980632,0.013566117,-0.033180013,0.07884009,-0.0010700957,0.005951289,-0.12587135,-0.027314438,-0.030227875,-0.014569585,-0.037716992,0.044899423,0.016522493,0.053759042,0.056096658,0.016269464,-0.01112655,0.020190967,0.025056606,0.042875547,0.011092801,-0.025092127,0.06901872,0.026073596,-0.06813487,0.016561769,-0.065377295,-0.037894122,0.012124051,-0.058512155,-0.050515417,-0.056240674,-0.022982407,0.0938887,0.12170798,-0.006660113,-0.01878617,0.008543695,0.019318866,0.012452989,0.12881704,0.1185399,-4.3451e-08,0.012695518,-0.03537309,-0.0074362108,-0.019936854,-0.04457088,-0.020696824,-0.022739049,-0.0137123335,-0.020077225,-0.03604282,-0.04775397,0.065637074,-0.0014449998,-0.028882211,0.054012354,0.0055658184,0.024613667,0.03937485,-0.012772086,0.02329993,0.04866413,0.008053406,-0.09435587,0.05164884,-0.004872304,-0.16237386,0.04874415,0.07236275,-0.018241894,-0.01954086,0.09773482,0.0195677,0.020010915,-0.0023717054,-0.00883598,0.031801496,-0.047756955,0.041968793,0.06376007,0.04206011,-0.031563524,-0.105124995,-0.03755133,-0.018502302,-0.0032632113,-0.07420507,0.00094285276,-0.027824854,0.061815128,0.005183487,0.05060001,-0.011654924,-0.013640608,-0.022766283,0.011880672,-0.027156895,0.008199816,-0.07669201,0.041863482,-0.07583798,0.0002362162,0.005839813,0.05410654,-0.0052375086 +4.2.3.120,"Cyclase II of Salvia officinalis (sage) produces about equal parts (-)-alpha-pinene, (-)-beta-pinene and (-)-camphene, plus traces of other monoterpenoids. The enzyme, which requires Mg2+ (preferred to Mn2+), can also use (3S)-Linalyl diphosphate (preferred to (3R)-linalyl diphosphate) [1-4]. The enzyme from Abies grandis (grand fir) produces roughly equal parts of (-)-alpha-pinene and (-)-beta-pinene [6-9]. Cyclase IV from Pinus contorta (lodgepole pine) produces 63% (-)-beta-pinene, 26% 3-carene, and traces of alpha-pinene [10]. Synthase III from Pinus taeda (loblolly pine) forms (-)-beta-pinene with traces of alpha-pinene and requires Mn2+ and K+ (Mg2+ is ineffective) [11]. A cloned enzyme from Artemisia annua (sweet wormwood) gave (-)-beta-pinene with traces of (-)-alpha-pinene [5]. The enzyme from Picea sitchensis (Sika spruce) forms 30% (-)-beta-pinene and 70% (-)-alpha-pinene [12]. See also EC 4.2.3.119, (-)-alpha-pinene synthase, EC 4.2.3.117, (-)-camphene synthase, and EC 4.2.3.107 (+)-3-carene synthase.",384,1.0,-0.027096398,-0.0994991,-0.022082414,0.027964545,0.06225369,0.017889183,-0.025827656,-0.01443316,0.053774815,0.021850605,0.0036649534,0.041766174,0.04187748,0.036732532,-0.05132151,0.05523298,-0.042739775,0.034469616,-0.017545829,0.05259014,0.13944322,-0.027996423,-0.041062783,0.042789165,0.06824496,-0.07209017,-0.0228721,-0.029652335,-0.03437101,-0.030596832,0.029786382,0.008678163,0.07954786,-0.040599998,-0.00435216,0.042779893,-0.060107663,-0.0416845,0.04234256,0.022224693,0.040590446,0.041404568,0.00044577816,-0.03216685,-0.013206042,-0.024943663,0.02916212,-0.02414246,0.034984186,0.0016396603,-0.057422273,-0.11896743,-0.04733672,0.029839465,0.005643382,-0.011378028,-0.062624104,-0.041964363,0.010120816,0.011954736,5.318792e-05,0.048928127,-0.034723897,-0.047265112,-0.037935354,-0.010130794,-0.08124655,-0.033467654,0.009466932,-0.08778667,-0.049981177,-0.07463776,-0.09018033,-0.0052369055,0.0025038724,0.0166156,0.011633671,0.03512395,-0.013015649,-0.06452808,-0.026809894,0.03647599,0.02285995,0.04298097,0.035983313,0.068848625,0.06236396,0.09767995,0.029625464,0.001363885,0.10889046,0.052386075,-0.045847036,-0.015514362,0.024352677,0.045885064,0.03057006,0.020863526,0.0006537932,-0.009530388,0.030812401,0.0015951927,-0.023596426,-0.1440319,-0.053694956,0.054109126,-0.002578335,0.020089857,0.026960097,0.0010165178,-0.013174078,-0.0003944042,-0.0055059013,0.058514845,0.013297598,0.10966765,0.057751924,-0.039466325,-0.047771264,0.022041822,0.04971719,-0.012798874,0.05878857,0.08371334,-0.011633785,0.12437299,-0.071356535,1.7470107e-33,0.014630806,0.08626329,-0.013755098,-0.011451994,-0.037312694,-0.0017076929,-0.03778856,0.025742631,-0.003816151,-0.013425632,-0.11765298,-0.033695824,0.027075123,-0.055759326,0.0063396534,-0.02104416,0.072570935,-0.038518585,0.075585745,0.017133841,-0.079093724,0.013956999,-0.084520474,-0.011983709,-0.0037649479,0.055326924,0.062841825,-0.0053150305,0.08781106,-0.04192647,0.05683721,-0.10891769,-0.05912897,0.02563975,0.057581153,-0.07171603,-0.058791034,-0.06460003,-0.026392084,0.029801875,-0.04467266,0.014896481,0.006740356,0.04237232,0.056467865,-0.07803255,-0.07660431,0.040397428,0.02873319,0.0029339886,0.036030162,0.061693184,0.043284994,0.008695542,-0.12910962,0.025537543,0.00020236602,0.048270088,0.064909235,0.04732756,-0.03516514,-0.028377037,-0.009311171,-0.034763224,-0.032915268,0.057325803,-0.11283675,0.012465156,-0.08746184,0.074992016,-0.008168417,-0.0997,-0.01578193,0.003045934,0.060795058,0.002897853,-0.0042825127,0.026276164,0.05324904,-0.022762133,-0.06707036,0.051074613,-0.006944681,0.053230394,-0.04994221,-0.10538178,0.006348833,-0.04019806,0.015378494,0.08996812,0.07413584,-0.020600138,-0.100704186,0.025239782,-0.0077411714,-9.731313e-34,0.025443599,-0.074346036,0.028511772,-0.076372035,-0.07671566,0.033225317,-0.0130229965,-0.116419524,0.034327608,-0.044992343,0.03568457,-0.021298517,0.0053616096,-0.01625924,-0.043507036,0.007511707,0.027362704,0.1715307,-0.020733012,0.024490288,0.017834395,0.06728398,0.014912934,0.0073279813,0.003321557,0.018927524,0.021698177,0.11347595,0.07227755,0.060457863,0.088868715,0.008517886,-0.054835662,-0.068289705,-0.058040373,0.044512596,0.0390435,-0.071787745,0.017722568,0.048171878,-0.032041892,-0.04221693,0.03952198,0.080570936,0.11392249,0.028391823,-0.036928672,0.008280754,-0.025025895,-1.3995868e-05,0.044614106,-0.008459548,0.0028262527,0.029063167,-0.0033681213,-0.027882425,0.049598068,0.038735673,0.052326888,-0.12394227,-0.013515031,-0.030182846,-0.02773585,-0.023706082,0.028803242,0.019315174,0.04307094,0.07329608,-0.006712518,0.007844825,0.011832262,0.01894667,0.023901815,0.011632807,-0.030231286,0.073089264,0.009589044,-0.06739373,0.006340236,-0.055403203,-0.01934954,0.049423207,-0.032841768,-0.060571562,-0.061592143,-0.0465874,0.08939767,0.12028565,-0.02869337,-0.046238203,-0.007252084,-0.0011557178,-0.028779536,0.0960463,0.12608045,-4.253013e-08,0.0023419922,-0.04704145,-0.014447966,-0.04017889,-0.023187298,-0.017656857,-0.024845384,-0.010202348,-0.014885008,-0.032347184,-0.011167801,0.052503195,0.0020199805,-0.034981627,0.044824917,-0.0007326084,0.025845397,0.030507464,0.001187986,0.06373055,0.04989741,0.016231619,-0.08644627,0.03990304,-0.011537172,-0.18725245,0.030021476,0.07971763,-0.025603374,0.0052632373,0.08576477,0.044041514,0.030360844,-0.02765285,-0.035562653,0.029757384,-0.05990204,0.016455323,0.074085854,0.015567996,-0.027560903,-0.115289725,-0.03766915,-0.048356783,0.002290091,-0.08498982,-0.004778485,-0.029306203,0.07249856,-0.005726617,0.029439643,-0.014659413,0.0153939165,-0.04413955,0.009319913,-0.020559426,-0.0003025488,-0.057575867,0.023276905,-0.092992485,-0.020154433,-0.0153973,0.09552303,-0.020499904 +4.2.3.121,"Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-alpha-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-alpha-pinene and (+)-beta-pinene. (3R)-Linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. The 4-pro-R-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+) [1-4]. With synthase II of Pinus taeda (loblolly pine) (+)-alpha-pinene was the only product [5,6]. Requires Mn2+ (preferred to Mg2+). See also EC 4.2.3.122, (+)-beta-pinene synthase, and EC 4.2.3.116, (+)-camphene synthase.",384,1.0,-0.017686954,-0.09428195,-0.03637152,0.023414837,0.10531862,0.038211852,-0.017566634,0.04083212,0.053341266,-0.014673886,-0.0020293945,0.054867186,0.017599164,0.047144953,-0.029516792,0.013997264,-0.027689496,0.039469056,-0.017111735,0.019810341,0.11490727,-0.021088816,-0.017461054,0.05745454,0.09433774,-0.08433719,-0.00056403666,-0.0088416925,-0.038470395,-0.043764934,0.07590599,-0.0071498365,0.08205993,-0.07887454,-0.00231384,0.015356955,-0.0644677,-0.06663814,0.035814136,0.0834283,0.029933292,0.0068083582,-0.0058338465,-0.023382273,-0.0125359595,-0.040113527,0.035706695,-0.016754126,0.0560114,-0.0033853415,-0.08593077,-0.099013545,-0.04222688,0.012615559,-0.011076927,-0.030934354,-0.07944168,-0.022112017,0.008228527,-0.000487625,-0.020712579,0.039563794,-0.039627675,-0.07631697,-0.018944496,0.0033073248,-0.055965662,-0.055554524,0.03921864,-0.038692743,-0.052882995,-0.057608746,-0.0723341,0.027836109,-0.0032031161,0.0009021485,0.01151594,0.041576322,-0.019611375,-0.091416694,0.00712186,0.042626873,-0.044269864,0.0040520458,0.04361783,0.07914846,0.040426422,0.08996612,0.031727873,-0.02064774,0.092292495,0.018310314,-0.059867788,-0.014608535,-0.0047059054,0.057011217,0.00452185,-0.006859985,0.0015292062,0.0059862467,0.045760084,0.0015051358,-0.032209482,-0.17851837,-0.03405138,0.06486209,-0.011865021,0.038113944,0.004609864,0.010404038,-0.0040556565,-0.0063049225,-0.025759393,0.05765615,-0.013959867,0.116214275,0.061560623,-0.022064487,-0.07124588,0.01549915,0.04596903,-0.042510625,0.06667906,0.044282205,-0.024720242,0.101593934,-0.056359295,3.6242166e-33,0.010725354,0.05354872,-0.03547108,0.017468764,-0.03879538,0.020065077,-0.06731274,0.0018070114,0.001804599,-0.028378475,-0.09395662,-0.04556871,0.016615279,-0.063986525,-0.0013272566,-0.02615851,0.07240161,-0.042583942,0.079434,0.0077573247,-0.08583132,0.05426312,-0.070458725,0.014997312,0.012870372,0.047827434,0.09139792,-0.014114097,0.108881265,-0.035000604,0.093959995,-0.09260597,-0.07213155,0.036918405,0.04226454,-0.07737749,-0.07718992,-0.0839216,0.020698626,0.020478426,-0.036721546,0.03517631,0.0076013748,0.05439156,0.066193275,-0.09249557,-0.046959996,0.06736904,0.04468584,0.012636119,0.033474494,0.04274452,0.07160561,0.0041017565,-0.12003894,-0.011177803,-0.010302229,0.08507301,0.07154121,0.065937646,-0.06664881,0.01816297,0.019126708,-0.047580823,-0.015495717,0.050128836,-0.13783266,-0.013074206,-0.07152767,0.05702047,0.024299897,-0.10394615,-0.008693674,0.0494093,0.009387181,-0.024859846,-0.01837512,0.03630445,0.054178577,-0.002560037,-0.053523805,0.07622246,0.017047925,0.09602033,-0.06965188,-0.071310945,-0.022125576,-0.032826245,0.01794834,0.09962894,0.069564104,-0.011676073,-0.07486613,0.001550258,-0.0053521204,-1.904542e-33,0.040855616,-0.056618642,0.016817978,-0.041943766,-0.052546397,0.022669783,0.0015459998,-0.1207737,0.018406527,-0.058100536,0.05192715,-0.05150272,-0.0144418,-0.03674812,-0.022668336,0.025396492,0.018060338,0.13928923,-0.019239685,0.026444161,0.028773358,0.06910024,0.02824413,0.035078008,-0.003851047,0.037418794,0.040513296,0.07791757,0.06643171,0.05987106,0.08744026,-0.007934313,-0.062003423,-0.08461055,-0.049930762,0.03212462,0.06322593,-0.043297928,-0.019030662,0.04496124,-0.036087774,-0.01602587,0.07620022,0.06319021,0.09171965,0.042105503,-0.034785744,0.008949802,-0.020052731,0.015818859,0.023882456,-0.036228802,-0.0077221165,-0.000978303,0.0143888425,-0.04705771,0.06550944,0.0035499602,0.027667284,-0.11658812,-0.022042165,-0.0145953605,-0.005950389,-0.019530434,0.019667868,0.024708087,0.031967077,0.03364048,0.004472969,-0.021720996,0.029818816,0.005106227,0.019928448,-0.0046340916,-0.04347327,0.079503484,0.003424391,-0.013763672,0.04143423,-0.0798021,-0.013700352,0.0076280273,-0.06791123,-0.066474564,-0.049572747,-0.00043682914,0.055830356,0.10976618,0.0028902255,-0.031404607,0.027660655,0.002090843,-0.0006781458,0.09406275,0.15494786,-4.35278e-08,0.028232016,-0.078372516,-0.014324212,-0.036570646,-0.011249194,-0.026498646,-0.007915639,0.015737046,-0.020809557,0.0005921486,-0.030251225,0.04291368,0.022602217,-0.04403541,0.053592596,0.016814152,0.042941086,0.06095524,-0.016969018,0.04468956,0.058607407,0.0013645903,-0.09435787,0.04387547,0.014480211,-0.14801455,0.052004,0.06617723,-0.022311369,-0.023279367,0.10941034,0.020978019,0.016352734,-0.0012971867,0.0013823773,0.024449272,-0.053014487,0.059439532,0.03947537,0.021396555,-0.054720245,-0.0930554,-0.05201078,-0.023335189,0.00021473404,-0.06629477,-0.012732874,0.0018670545,0.031877887,-0.025548706,0.006846637,-0.033674963,0.00962443,-0.05037182,-0.00993566,0.005066628,0.010846475,-0.077244475,0.039673425,-0.08735244,-0.011663341,-0.010987667,0.047795735,-0.0030097784 +4.2.3.122,"Cyclase III from Salvia officinalis (sage) gives roughly equal parts of (+)-beta-pinene and (+)-alpha-pinene. See EC 4.2.3.121, (+)-alpha-pinene synthase. ",384,0.99999994,-0.03193261,-0.06061329,-0.02429916,0.034593638,0.061193172,0.054625228,-0.035613187,0.014917528,0.058015626,-0.028381677,0.0027314473,0.023772744,-0.0007434788,0.03123812,-0.040244658,0.0088745635,-0.08811986,0.077803075,-0.017552594,0.0077045257,0.06644776,0.031516816,-0.0019342357,0.08742824,0.10231299,-0.06640069,-0.043980654,0.024068521,0.014840905,-0.036004044,0.07222056,0.001816234,0.12271108,-0.051497716,0.0031938101,-0.019451017,-0.059556253,-0.067345604,0.07027876,0.0566381,0.04225964,-0.010243175,-0.027586002,0.03609185,0.007150581,-0.00026272424,-0.017735012,0.03411225,0.070191085,-0.030673187,-0.060859628,-0.12363909,-0.11276919,0.07506612,0.019685155,0.052542247,-0.08190815,-0.048874777,0.013273626,0.004505508,0.0051076873,0.026338045,-0.030425085,-0.04388302,-0.036761586,0.024919776,-0.0066121775,-0.058077723,-0.017226798,-0.04188964,-0.041558992,-0.035838235,-0.0810673,0.048814293,-0.0052400324,0.032735035,-0.045037545,0.025909338,-0.07473871,-0.08047141,0.014572149,0.018662263,-0.054677818,0.05541037,0.044713426,0.031658083,0.041859947,0.047187373,0.031120494,-0.0033637385,0.044437658,-0.002228359,-0.03426803,-0.0071003176,-0.026766986,0.009438391,0.05233187,0.011181357,0.022835864,0.007944843,0.031035798,0.003847359,-0.018132823,-0.13673793,-0.06000441,0.07663616,-0.016354464,-0.013072007,-0.02186014,-0.024584506,-0.014252575,-0.037262943,0.008416366,-0.008229835,0.014480768,0.106784314,0.08547243,0.016430203,-0.05104649,-0.011033684,0.033713847,-0.018499939,0.066126324,0.07837867,-0.029409751,0.07375946,-0.07259345,1.1777356e-33,0.004541428,0.07510644,0.0108239595,0.035792384,-0.032070193,0.006085971,-0.07135814,0.006885453,-0.015475233,-0.03418327,-0.07984842,-0.011811435,0.0041427817,-0.066744015,0.019914502,-0.013272632,0.06132778,-0.050265666,0.012486076,-0.021440629,-0.1183067,0.017978966,-0.08569961,0.011747466,0.028871268,-0.0058905846,0.06897897,0.0057861074,0.08911503,-0.03459366,0.05676388,-0.012489511,-0.064933494,0.048719894,0.040363595,-0.047306664,-0.061598983,-0.08303165,0.036709927,0.084133096,-0.040075134,0.020396402,0.04776404,0.008315095,0.050137382,-0.059538856,-0.09351595,0.026333774,0.06931618,0.0014177279,0.00034069433,0.06555166,0.055274583,-0.00039712593,-0.12565178,-0.026639204,-0.0003614718,0.10007636,-0.02555781,0.051274985,-0.036667317,0.019499373,-0.0026127254,-0.05707771,-0.08894929,0.066702046,-0.12305322,0.015842674,-0.06128257,0.059653316,0.006173501,-0.022154056,0.009062977,0.05089826,0.05253933,-0.019982498,-0.059570253,0.050089344,0.047102075,-0.018051447,-0.10855565,0.067414716,-0.00925174,0.05595122,-0.062204693,-0.052298587,0.0039625503,-0.028227203,0.021547234,0.037945975,0.061938867,-0.020309858,-0.06659357,0.022514496,-0.0051622405,-3.1867994e-34,0.010777876,-0.09033649,-0.008190765,-0.037735622,-0.048369072,0.04536265,-0.01849898,-0.06532253,0.016368695,-0.010887608,0.06766513,-0.010531458,-0.023975957,-0.081425294,0.025050927,-0.019943492,0.018091284,0.1438315,-0.027934434,0.036448743,0.02133327,0.02649631,0.008724892,0.020250218,0.016961101,0.063186854,-0.0014984822,0.098701485,0.09266637,0.024444424,0.087006554,-0.018069359,-0.07919265,-0.08715039,-0.075286195,0.030593785,0.07885746,-0.03701898,-0.02295847,0.040286366,-0.028042035,-0.05828636,0.07635745,0.07134636,0.12131868,0.04214293,0.058803603,0.016301602,-0.049728632,-0.0012516875,0.08291788,-0.0025441241,-0.01134805,0.06351164,0.016153105,-0.02633329,0.0512531,0.021831376,0.034726717,-0.114075035,-0.012883636,-0.0020323882,-0.038714875,-0.010259936,0.013125589,-0.03319735,0.03246259,0.06018683,0.010211246,-0.021347104,0.05373225,-0.0035130004,-0.022832654,0.013809502,-0.05996474,0.03944771,0.011233577,-0.048820447,0.022261696,-0.04278604,-0.03441408,-0.0007177029,-0.03125938,-0.018228289,-0.06866112,-0.015321009,0.051651686,0.08463806,-0.023413248,-0.0033287534,-0.013968441,0.07642959,-0.040619936,0.080331594,0.13812077,-2.9589001e-08,0.08229797,-0.07213197,-0.07571124,-0.051204894,0.023992104,-0.05853347,-0.0125896465,0.044828046,-0.028832851,-0.012522338,-0.042565044,0.046606127,0.053406157,-0.048453193,0.01633964,0.04647032,0.047316555,0.04556472,-0.0041715456,0.036063697,0.016534327,0.029396975,-0.04346461,-0.010353393,-0.05898291,-0.14058521,0.038260557,0.0681375,-0.04372646,-0.0144237075,0.11896363,0.008941544,0.016783886,-0.031688113,0.007995507,0.055867966,-0.017925043,-0.0062121307,0.08813441,0.0055720415,-0.048811816,-0.13280766,-0.062599786,-0.0005040406,0.050531354,-0.075399734,0.00871469,-0.033253383,0.022359814,-0.05553368,0.019778185,-0.03239243,0.033258863,-0.048901476,-0.05709572,-0.016584355,0.014271258,-0.042924237,0.04792401,-0.07224857,-0.004456667,-0.024450403,0.116409875,0.027926357 +5.3.2.5,"The enzyme participates in the methionine salvage pathway in Bacillus subtilis [2].In some species a single bifunctional enzyme, EC 3.1.3.77, acireductone synthase, catalyses both this reaction and EC 3.1.3.87, 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [1].",384,0.99999994,-0.09992389,-0.030410744,-0.0070453044,0.002742005,-0.011365576,0.04340574,-0.10338137,0.042449947,0.020595463,-0.016139487,0.008325699,-0.10385747,0.035364315,0.01813131,-0.053633146,0.05434208,-0.08279205,0.0010787289,-0.020436348,-0.05900339,0.058239177,0.07915656,-0.064569235,-0.041797243,0.070925325,-0.07052348,0.07013038,-0.049889203,-0.02982556,-0.059427895,-0.06763196,-0.046351787,0.053703927,-0.031346668,0.06387605,0.11826491,-0.013793067,-0.024343293,0.10086494,0.012177962,0.06663289,-0.004808803,0.0006246171,-0.05136603,0.013833329,0.03663657,-0.0016097359,0.007408734,0.074431434,-0.05436709,-0.104533434,0.004667544,-0.005609361,0.0265925,0.043980945,0.016987756,-0.022683874,-0.016624322,0.009973777,0.0056135203,0.007145766,-0.04770719,0.01663523,-0.047016118,0.073436156,-0.086443946,0.014007814,-0.06502477,0.042681485,-0.01986286,-0.05324837,-0.025714796,0.015690736,-0.029047994,0.04180468,-0.028659515,-0.05453676,-0.029998465,0.047534954,-0.061801404,0.033586226,-0.029225102,-0.009446624,0.053381592,0.06889181,-0.029110705,0.009939795,-0.030376356,0.06228403,0.02899749,-0.0650796,-0.058345724,-0.02907002,-0.07381911,-0.033395782,0.032126058,-0.018160375,0.07764192,0.01717659,-0.0063868896,-0.041146103,0.06415298,-0.04999189,-0.025792202,-0.10748354,-0.056586865,0.0816985,0.06780518,0.04973737,0.047311157,0.06137727,-0.029522285,0.056617554,-0.05982306,-0.032483526,0.08320565,-0.006998798,-0.062492862,-0.044754043,-0.035354294,-0.0069060116,-0.029733313,0.05328143,0.015688471,-0.023288643,-0.024589507,-0.0443974,1.4747487e-33,0.052480225,0.04843352,0.015630586,-0.0075400425,0.049155083,-0.04718554,-0.11755709,0.011133476,-0.06322527,-0.116664544,-0.028120471,-0.05328486,0.004785783,0.050456095,-0.062128525,-0.03281386,0.033361964,-0.01254711,-0.01092309,-0.04955681,0.021574367,-0.03353405,-0.015736703,0.06584011,-0.012506678,-0.026760478,0.04038834,0.022863377,0.016694818,-0.010536976,-0.016908482,-0.0010530773,-0.05736974,0.04199563,-0.009678621,0.045297887,-0.10683918,-0.016438678,-0.026410587,0.085838936,0.0033043046,0.031492505,-0.013235253,-0.048346285,0.025205964,-0.03216072,-0.10004589,0.121994905,0.06943443,0.10774317,0.011250937,-0.00036918544,0.13157164,-0.0379167,-0.06808144,0.030300045,-0.018153109,-0.05828681,0.041200712,0.039992727,-0.01872772,0.03525274,-0.04350044,0.066375256,-0.07294905,0.041129533,-0.03995222,-0.0017396985,0.059360128,0.06300913,-0.03734421,0.026152994,0.008321994,0.040815935,-0.053001948,-0.003130557,-0.047196902,-0.034443293,-0.02721964,0.037846465,0.087545216,-0.0362174,0.032334074,-0.03189976,-0.037478805,0.009025065,-0.036510378,-0.07984195,0.047999084,0.041071266,0.01192082,-0.07614679,-0.052992884,0.06361119,0.008186809,-1.8978841e-33,0.14512187,-0.06426238,0.06976647,-0.105536155,-0.08200911,0.01562956,0.03232791,-0.01013528,0.048435736,0.024226852,0.056924812,0.008166861,0.06127177,-0.038109522,0.026328586,0.018961113,0.056063376,0.1092554,0.07372316,0.01805874,0.06948053,0.07207861,-0.036448017,0.0009106686,0.057706945,0.03250642,-0.033955272,0.13990813,0.012805434,-0.0026781769,-0.029165626,-0.046557028,0.00223461,-0.007206973,-0.03797214,0.09168076,-0.037138022,-0.00896987,0.040025827,0.038254775,0.00790846,0.06421638,0.0075575397,0.056128696,0.09101473,0.07091326,0.017171118,0.013255226,-0.018053584,-0.13345137,0.059144296,-0.010833716,0.015986057,-0.07314815,0.0025933587,0.08543593,-0.044535216,0.078268185,-0.0016098947,-0.10726691,-0.031849474,-0.054226827,0.06966065,0.034302022,0.016281804,0.07110483,0.03295279,0.023757514,0.0129622305,-0.0090673,-0.009341723,0.008769588,0.04987669,-0.0038936366,-0.041134655,-0.028293855,-0.11596703,0.06698967,0.004979229,0.0027444656,-0.0007614087,-0.04132018,-0.041661374,-0.047503557,-0.029707259,0.0044506667,0.01937647,0.07931846,0.023920782,0.028972285,-0.1258785,0.025367048,0.0051737586,0.0306104,0.043111794,-4.049149e-08,0.1358605,-0.08550504,0.003018311,-0.014333846,0.06910337,-0.0174732,-0.0036103807,-0.022538392,0.06576209,-0.0032396694,-0.07043457,0.010676188,-0.010219756,-0.012783833,-0.0005186631,0.026529394,-0.01740506,0.011195916,-0.032653254,-0.019523002,-0.045919687,0.019295339,-0.056062873,0.07341459,-0.0143795125,-0.030062955,0.025629103,0.009627456,-0.09446963,-0.074796304,0.0051766387,0.044200942,0.0024211805,-0.046240952,-0.09768997,-0.009447936,-0.06872041,0.004378123,0.009849871,0.0019186185,0.051211476,0.03905368,-0.018129038,0.04542574,-0.020229623,0.022926975,-0.033604685,-0.0046232142,-0.02813313,-0.03390021,0.041258063,0.02982757,0.043929826,-0.026983129,-0.09911848,-0.0012754777,0.015228913,-0.046380088,-0.03972834,-0.010565834,0.021663351,0.01197394,0.1661537,-0.052570935 +5.3.99.10,"The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate.",384,1.0,-0.033231046,0.006894627,-0.014339607,-0.02159539,0.03930962,-0.04739143,0.013994548,-0.041068267,-0.0028983678,0.043823518,-0.03599932,0.057125967,-0.06431512,0.0447434,0.014277294,0.08937102,0.014023425,0.051810917,-0.04931246,-0.022929393,0.08436088,0.0687257,0.04246764,-0.024358535,0.005571386,0.056528956,0.005880283,0.0743994,-0.038769186,-0.13323101,0.019667566,-0.028112752,-0.043967023,-0.082641274,0.013192371,-0.00039372232,-0.06909002,-0.0040568854,0.025017371,-0.09466302,0.072532386,-0.0788572,-0.03811656,-0.07709233,-0.09122363,-0.058990255,-0.027315116,0.028308285,0.06681174,-0.0028218399,-0.06710606,-0.027166935,0.029014051,-0.026990846,-0.13049684,-0.03926374,0.014705306,0.019099599,-0.10705055,0.025448145,0.0318356,0.0029720692,-0.06627602,0.054048833,-0.031535894,-0.034926068,-0.035323422,0.0061770095,-0.013109395,0.02938838,-0.035890054,-0.0637493,0.014363654,-0.049570993,0.0040186974,0.004631795,0.044774473,-0.03251119,0.017712781,-0.013657088,0.041751046,0.00019549672,0.012003323,0.05769628,0.03539011,0.08252919,-0.021636883,0.0378504,0.08489516,-0.006470052,0.045589067,0.04432956,0.010230906,-0.016635265,0.013266306,0.055479124,-0.031222662,0.021117663,0.01754441,-0.013736452,0.08325881,-0.028076224,-0.038363025,-0.08425048,0.004151238,0.029678581,0.026260285,0.01449668,0.011895468,-0.048225235,-0.06979722,-0.012861678,0.036737263,0.028304454,-0.082721405,0.026568677,-0.00013870695,0.06331162,-0.0031036306,-0.09063405,0.0015137352,-0.026155453,0.055125207,-0.033976864,-0.010905295,-0.042477608,-0.13095622,6.2547774e-34,-0.033661503,0.1319752,0.0110703055,-0.035453595,0.058964808,-0.0104805315,-0.03857799,0.04352166,-0.10886986,0.03930855,-0.06687465,0.00831297,0.02463089,-0.07924106,-0.01204813,-0.078508586,0.0056074657,0.16877247,0.024934426,-0.011762419,0.015392372,0.067743264,-0.09241428,0.032133646,-0.09414401,0.09073497,0.02060171,0.037741255,-0.027990028,0.004838799,0.004190282,-0.033750035,-0.06548816,-0.03951349,0.113317095,-0.045762245,-0.028195072,0.052324478,0.061941706,-0.010403315,0.0075938376,0.0048487606,-0.024263898,0.05621532,-0.08756822,-0.03326862,-0.051609278,0.090246625,0.05386296,-0.0022953353,0.033109285,-0.09234829,0.07590135,0.04200807,-0.08822739,0.05798526,-0.0045093913,0.03426674,0.0866652,-0.054726426,-0.023779713,0.0202666,-0.006378309,-0.025548156,-0.04408218,-0.07543292,-0.018760737,-0.042736907,0.008293448,0.16006017,0.033729296,0.0635832,0.061517153,0.010603502,0.123564504,-0.010587204,0.02696424,-0.021254621,0.05673155,0.050697543,-0.04077895,-0.036070652,-0.038586695,-0.029641159,-0.051400606,0.004845227,-0.028132241,0.058350373,0.02150844,0.055873357,0.03986973,-0.14953633,-0.021183118,-0.027919635,-0.021121087,-2.1868487e-33,0.09708547,-0.005186606,0.061985712,-0.017230235,-0.0075639384,-0.09251356,0.0071961046,-0.0059628366,-0.020593474,0.05583072,0.10481842,0.00351226,0.07562302,0.010546374,6.029161e-05,-0.00066676165,0.08748186,0.022189323,0.025846468,-0.08951429,-0.010001874,0.018187333,0.019691573,0.0053699003,-0.013760174,0.03949515,0.070453994,-0.0060597397,0.0320845,0.05755049,-0.015441924,-0.011025013,-0.004135311,-0.039416306,0.03713058,0.08841511,-0.07837,-0.036341026,-0.032657225,0.026258357,-0.046730183,0.01637122,-0.012440463,0.05978296,0.055421226,-0.022078807,-0.08263764,0.00836422,-0.0060069337,-0.06459111,0.08716612,0.04433127,-0.037970755,-0.002591727,-0.004928889,0.06537755,0.03008011,-0.046964254,-0.03887383,0.005092348,0.00044442038,-0.049576808,0.014419293,-0.0037113023,0.011702763,0.025321597,0.009125497,0.038779005,0.04007037,0.008960672,0.019878965,0.031532783,0.006710766,0.061208162,-0.0357294,0.01147884,-0.03810801,-0.04216963,0.0024094873,-0.036293857,0.011143418,-0.017635891,-0.02925741,-0.1006144,-0.039816856,-0.058853857,0.03003444,0.09545183,-0.06331437,0.025035147,0.00931044,0.01676431,0.0087598385,0.15419653,-0.006268221,-3.6719403e-08,-0.0063287118,-0.10265336,0.032926124,-0.04384838,-0.033670902,0.04882783,-0.068385206,-0.038343024,0.13555661,-0.034045674,-0.01211904,0.043675758,0.03060861,0.07338503,0.041012716,0.047106173,-0.015578623,-0.023710366,-0.0047212113,-0.10424303,0.030187596,0.028539447,-0.10707549,-0.022074958,0.049673263,0.0061146403,-0.020163052,-0.017343985,0.016458007,-0.054144293,0.018658973,0.04552195,-0.0072177774,0.039704684,-0.025973737,0.030383032,-0.08225603,-0.05025958,-0.09449939,-0.043765545,-0.0101890955,-0.051182177,-0.043532044,0.03572104,-0.06455748,-0.036933627,0.03952188,0.028414872,-0.05389263,-0.05438999,-0.047401547,0.06513112,-0.049262274,-0.021576371,0.00750855,-0.038568597,0.0025282027,0.022226205,-0.022978894,-0.017340414,0.046824303,0.048381876,0.10516482,-0.05616847 +6.3.4.20,Binds Zn2+. The reaction is part of the biosynthesis pathway of queuosine.,384,1.0,-0.10155768,-0.03807183,-0.09132981,0.06298907,0.065954074,0.022040112,0.061586007,0.08806473,0.078842014,0.0016998504,0.05790794,0.0074435724,-0.04266553,0.027358571,-0.06962011,0.026515538,-0.06934151,-0.00565103,-0.034128714,-0.032501582,0.049494214,0.06224835,0.020225119,-0.051151138,0.006211507,0.024469709,-0.010180525,0.00019026747,0.10721323,0.0040278155,0.013519449,0.026940636,-0.0058545475,0.0059073446,-0.0050476193,0.012196651,0.07541479,-0.10523293,0.021054652,-0.041037496,0.1098778,0.021342484,-0.007790016,-0.02878622,0.061948057,0.050794296,0.056686312,0.026223311,0.002610402,0.016583772,-0.071354985,-0.014416484,-0.07478101,0.03805929,0.012917578,0.08017414,-0.06976702,0.057185877,-0.01750339,0.007045971,0.016736299,0.00864904,-0.015564075,0.040675588,0.067179546,-0.056590397,-0.011726036,-0.0022605201,-0.0011267896,-0.00794904,-0.06743744,0.0018933448,0.02901827,-0.009727504,-0.0024745325,0.08237403,-0.0040747616,-0.08403033,-0.04646582,0.0021481225,0.031793468,-0.02696578,0.09067203,0.1118673,0.05399943,0.00034137655,0.026085982,-0.03345129,0.047847923,0.06610113,-0.013918402,-0.01698389,0.058137003,-0.0447302,-0.08361196,0.037421305,0.040145535,0.01558227,-0.02153363,0.020980218,0.025335526,-0.009659623,0.006112484,-0.038148902,-0.035810176,0.07317311,0.06820955,-0.03052491,0.0054422617,0.046374306,0.005516592,-0.049972195,0.035385434,-0.02590427,-0.009961375,0.09343431,-0.029091341,-0.006629328,-0.06829302,-0.057384614,-0.012612931,0.045115873,-0.09085407,0.00014551466,-0.0615928,-0.011578729,-0.10957241,1.04043905e-33,0.04037127,0.08554678,0.014351004,-0.017742502,-0.014156323,0.017214876,-0.0434804,0.011642223,-0.033234466,0.064636916,-0.045664415,-0.14474036,0.02187747,-0.008871491,-0.053992186,-0.026916072,-0.015176989,-0.013984395,0.038706478,0.030398278,0.030404437,0.01573086,-0.100646034,-0.036992367,0.056128807,0.06427761,-0.04254821,0.0019085358,0.0017422854,-0.03930717,0.023396859,-0.049343597,-0.085870534,0.009393993,0.10436702,-0.05896157,-0.0033146814,-0.031827252,0.004026616,-0.061522916,-0.010774056,-0.017874667,-0.091708355,0.037677236,0.008553251,-0.06266696,-0.015900696,-0.006151548,0.10447139,-0.05918103,0.007332719,-0.09191774,0.05263988,0.054387376,0.009785348,0.012722331,-0.045951013,-0.022539975,0.013764196,0.049279764,-0.0013995031,-0.05073722,-0.04220636,0.026463326,0.017089166,0.11279541,-0.08449475,-0.09009115,0.041359752,0.03139108,-0.020104133,-0.08559841,0.09265765,-0.018992187,0.07688649,-0.018199818,-0.051838864,0.034860406,0.046640553,0.03433172,-0.024962962,-0.08127837,-0.039901067,0.008574489,-0.090032496,-0.028160682,0.021347385,-0.038207576,0.043332588,0.023691276,0.032622937,-0.11681822,0.013994987,-0.03025902,0.025838593,-1.4004409e-33,0.009787243,0.0107695265,-0.00926229,-0.0480929,-0.064403035,0.037416052,-0.052083347,-0.13030072,0.0041398024,-0.002495411,0.03492054,-0.0063686995,0.045336712,-0.04795443,-0.039803118,0.02875673,0.01616207,0.029805,0.06612903,-0.033112615,-0.025080197,0.016402524,0.015055276,0.0067798607,0.009344925,0.04642645,0.08715746,-0.020996861,0.042183883,0.09926145,-0.104762085,-0.052503295,-0.08332556,-0.08196519,-0.0011165558,0.0009830447,0.0038474256,-0.02677737,-0.090854704,-0.08771899,0.019604256,-0.05116761,0.062567174,0.15820813,0.04554845,0.015827997,-0.055446856,-0.0134045025,-0.059157345,-0.004626457,0.037512522,0.069824465,-0.058189962,0.024988074,0.020061769,0.052222088,0.0365911,0.00051567936,0.044257812,-0.07006817,8.933064e-05,-0.077174105,-0.0056944597,-0.024319109,0.06380002,0.012240608,-0.020403031,0.17661764,0.063758664,-0.010144607,0.046250265,0.04890598,0.12469047,0.033711106,-0.084404014,-0.026564391,-0.057820495,-0.08914412,0.04321427,-0.0031004683,-0.022063851,-0.0022992415,-0.02714049,-0.0356112,-0.027477242,0.016491555,0.014205591,0.06973061,-0.035616603,-0.052072838,-0.0061699,-0.04098839,0.003958386,0.062504284,-0.06833841,-2.2267233e-08,-0.06881152,-0.06772431,0.02208744,-0.024354689,-0.041688498,0.018203247,0.008862884,0.08540901,-0.026088707,0.0370419,-0.009288948,0.088175245,0.07591833,-0.00084726606,0.09632903,0.041058768,-0.016783807,-0.053964317,-0.031378344,-0.06434647,0.0083463825,-0.022861527,-0.082431644,-0.0056637474,0.0034536675,-0.06208711,0.016045712,0.08960275,-0.011036772,-0.03120058,0.029537007,-0.037729587,0.011766591,-0.03004575,-0.0025467242,-0.0059714974,-0.008695267,-0.08327624,0.012033114,-0.049728982,-0.03441834,0.10279297,0.021964822,0.058349002,-0.031608745,0.036556806,0.120510176,0.0037928962,0.04373284,0.022542994,-0.01528981,-0.042269804,0.0090116905,-0.053530704,-0.06061195,-0.04655247,0.049951248,0.055775583,0.015522185,0.07419004,-0.056917634,0.027925456,0.07969208,-0.011769352 +1.1.1.327,"Contains Zn2+. Isolated from Pseudomonas putida, and involved in degradation of (+)-camphor.",384,0.99999994,-0.0862495,0.030671021,-0.064680934,0.01983492,0.12806056,0.054913484,-0.036014102,0.071307115,0.014167603,-0.030728823,0.080485344,-0.03992974,-0.044135496,0.08812542,-0.0670352,0.01403367,-0.025105814,0.038738407,0.0060104476,0.053631768,0.031002391,0.1368731,-0.004235597,0.006737145,0.023354016,0.033210225,0.0014198538,-0.0053795837,0.045751456,0.031590305,-0.07780324,-0.017175501,0.047723487,-0.07753929,0.07383246,-0.0021943578,0.047304668,-0.03999648,0.087564744,-0.02687726,0.056548845,-0.003466499,0.01574774,-0.08184879,0.027695775,0.0022118865,0.071140684,-0.016851844,0.0064058425,-0.049302597,-0.07094129,-0.028728966,0.019723387,0.08394551,0.07321358,0.033252753,-0.077934295,-0.014679675,-0.059748724,0.023677623,0.035827182,0.009194016,-0.03665394,-0.029437779,0.0073464373,-0.0103330035,-0.018586079,0.029813908,0.030291075,-0.009112899,0.005734366,-0.015677534,0.09898177,-0.010013155,-0.059859604,0.027404267,0.057409547,-0.09256399,0.010342963,-0.05383089,0.03156447,0.0009220911,0.07586036,0.05379802,0.0015374369,-0.010822274,0.057852685,0.05382628,-0.002590759,0.039432466,0.005351923,0.008249953,-0.012112762,-0.037388336,-0.040726896,0.05200148,0.046114348,0.056570627,0.026103787,0.0010120393,0.015235232,0.015701575,0.012293621,-0.15903696,-0.061972566,0.040813442,0.08778708,0.038098473,0.042975537,0.040515307,-0.011051292,0.019232675,-0.031386178,-0.032149162,-0.041626316,0.036639195,0.05260487,-0.07789336,-0.093825474,0.019536845,-0.008239303,-0.073457256,0.033353932,0.05148216,-0.037437852,0.01789159,-0.05951695,-2.1641722e-33,0.01636188,0.006281625,-0.016364263,-0.0045865127,0.07279594,0.04432443,-0.084885776,-0.021871714,0.010168797,-0.015283758,-0.11016958,-0.1274572,-0.055163514,0.04094279,-0.013787844,-0.0471818,-0.03658759,-0.05067709,0.078710906,0.0026498747,0.032636397,0.02872209,-0.065193474,-0.057204068,0.094461404,0.006829079,0.061526503,-0.12395105,-0.010339702,-0.0247643,0.109016776,-0.055690933,-0.13726515,-0.005177437,0.11326069,0.010485534,-0.05071012,0.001937136,-0.05181575,-0.02857272,0.039792743,0.042415332,-0.055959072,0.03907013,0.06709607,-0.09371356,-0.087807134,0.10429147,0.060024932,0.010218322,0.00051364023,-0.004183013,-0.045151044,0.06697846,-0.09764311,-0.0074247145,-0.021119166,0.049523998,0.032554414,0.025625665,0.0154828215,0.054058313,-0.07163479,0.013034942,0.04047972,0.0060454733,-0.10626362,0.015501692,0.033133496,-0.030501751,-0.05238217,-0.033488695,0.012885903,0.054811385,-0.023606127,-0.10668236,-0.044861227,0.060868878,0.03866863,0.020879408,-0.03254783,-0.046341665,0.026071973,0.009661952,-0.13938344,0.05011332,0.011683663,-0.02506241,-0.0054688263,0.0014960774,0.066209175,-0.09199831,-0.079969734,-0.026056962,-0.027904175,1.0528962e-33,0.004011104,-0.033205505,0.04896647,-0.050068095,-0.03763743,0.0015110291,-0.098114565,-0.020775586,0.024082903,-0.047694825,0.02728697,0.026828408,0.079725504,-0.019006845,0.019074192,0.044616148,-0.041305784,0.025037462,0.040217075,-0.05388549,0.009079201,0.020455347,-0.040156208,0.050542805,0.05250399,0.07506416,0.014757194,0.09095639,0.07302492,0.07133093,0.04838319,0.021797748,-0.09893036,-0.0702492,0.021350943,-0.014889502,-0.021073822,-0.038389836,-0.020536747,-0.020378985,0.08900845,-0.02740936,-0.036858723,0.07691708,0.0075721745,0.066364,-0.04708895,-0.03546731,0.026452089,-0.07880966,0.049697574,-0.017063987,-0.07325314,-0.056419536,0.08193227,-0.027121391,-0.012875323,0.035820168,-0.038412537,-0.050238747,0.035935007,-0.011647339,-0.015345925,-0.015155689,0.044486932,-0.009830481,0.027092727,0.040507857,-0.01652299,-0.034913536,0.0727875,0.06474475,-0.01128145,0.0264636,-0.12743354,-0.005397773,-0.06527669,-0.046908382,0.05933545,-0.033916984,0.03833161,-0.07263706,-0.010595343,-0.037895728,0.054205276,0.033694346,0.048312757,0.11637676,-0.04594505,-0.034407854,0.015494578,0.020092368,-0.05196819,0.032240074,-0.05016871,-2.3579291e-08,0.05857154,-0.13597843,0.018300112,-0.031916954,-0.08551587,-0.0059124837,0.05533843,0.060250163,-0.007855092,-0.03426925,-0.014867451,0.030496467,-0.011418169,-0.042153455,0.032954447,-0.0018949364,-0.070134245,-0.008591148,-0.045416716,0.0004525543,-0.07377626,0.0026853215,-0.06523642,0.009416803,-0.017738907,-0.036239523,0.07212107,0.06373145,0.06576117,-0.06898739,0.06345025,-0.0059087565,0.042103622,-0.0100606745,-0.026673174,0.05938107,-0.0050274893,-0.072549544,-0.06589922,-0.006246658,-0.01641802,-0.051734358,0.008441336,-0.018645642,-0.017228361,-0.043608963,0.029279338,0.032634236,0.014652187,-0.048740517,0.037901916,0.010691111,0.021276817,-0.0013900461,-0.069905326,0.027379604,0.04239594,0.015647907,0.034141794,0.027433172,-0.014518383,-0.004804089,0.08830299,0.078757554 +1.3.1.92,Cloned from Artemisia annua. In addition to the reduction of artemisinic aldehyde it is also able to a lesser extent to reduce artemisinic alcohol and artemisinic acid. Part of the biosyntheis of artemisinin.,384,1.0,-0.070805825,0.042233028,0.018667143,-0.07680357,0.11850007,0.008124419,-0.0622669,-0.056170974,0.0003807412,-0.008201936,0.03610769,0.019407302,-0.096632496,-0.007789606,-0.053192563,0.09715188,-0.04743348,0.10245467,-0.05702908,0.0051903506,0.0029053017,-0.0012634868,0.045576934,0.045543667,0.051535558,0.017351268,-0.03914116,0.03176216,0.028692761,-0.0861214,0.021552447,0.07164542,-0.03393443,-0.075939566,-0.05039679,0.06698049,-0.030791674,0.0020299437,0.09430542,-0.050796397,0.060620442,-0.08458153,-0.032438934,-0.019873561,-0.06853524,0.042341277,-0.06285796,0.02896029,0.073344365,-0.025974963,-0.016285805,-0.055866547,-0.04537717,-0.033546545,0.04581417,-0.03217804,0.035298757,0.044125035,-0.010658586,0.06563869,0.08191964,0.065601565,-0.016444203,0.09293506,0.009278398,-0.010532418,0.012323827,-0.046817943,-0.006086095,-0.06764418,0.03279749,-0.06609278,0.076030806,0.044012524,0.021665178,0.03564926,-0.011908451,0.008054267,-0.018593628,0.030408112,-0.046790298,0.0043315594,0.015068804,0.11487024,-0.051653408,-0.03572114,-0.008662844,-0.04915811,-0.013220258,-0.0041672327,0.017044857,0.027562318,0.07622766,-0.05751229,-0.00700027,0.06885186,0.008752257,0.0029095598,0.028163707,-0.007037075,-0.0241614,0.05127623,-0.090198144,-0.104672134,-0.09664068,0.009605342,-0.030056326,-0.020912508,-0.00070086797,-0.008774976,-0.01757509,0.031408887,0.01073988,0.0157208,-0.037711874,0.018604953,0.04961696,-0.041002225,-0.050999563,-0.064878196,-0.04472879,-0.04722981,0.11279555,0.03985223,0.01633525,0.03220226,-0.023257535,2.2219365e-33,0.07720757,0.041618638,0.012133905,-0.0058697616,0.05940312,-0.0044118348,0.0075230747,0.011198662,-0.0041595814,-0.15076369,-0.079318,-0.106685765,0.025811248,-0.007289318,-0.013399318,-0.018476643,0.026142552,-0.05377851,0.054249704,0.045913097,0.0028968698,0.021219922,-0.02166991,0.0077863317,0.01700202,0.008005719,0.0164096,-0.009831532,-0.017323917,-0.008033928,-0.03836819,-0.018208591,-0.045177154,0.022711797,0.004417516,0.062237386,-0.000892087,-0.05034108,-0.034874607,0.026053064,-0.010440403,0.12149848,0.07485512,-0.04021124,0.07171338,0.01040859,-0.06121992,0.08648614,0.016700987,0.031944804,0.024526728,0.042065736,0.0016276385,-0.056746673,-0.07023796,0.039589882,-5.5908393e-05,-0.05937089,0.028552053,0.0125124995,-0.018911071,-0.03721028,0.021417456,0.0048839664,0.058292046,0.02403926,-0.033224832,-0.0538084,-0.048033617,-0.012117821,-0.08740014,-0.037696376,-0.031042526,0.046372417,0.034612954,0.003072438,0.027770326,-0.07898867,0.019643616,-0.06831209,-0.03906317,0.02595562,-0.0043264586,-0.04854583,0.004864001,-0.06734485,-0.02818633,0.014249188,-0.03161866,-0.035802633,0.07282001,-0.08231306,-0.08354087,0.0026738981,0.009220585,-3.9612018e-33,0.04513074,-0.15266359,0.033791803,-0.020605778,-0.021148,-0.0028746175,-0.0051267873,0.02470108,-0.024040263,0.05752392,0.057735413,-0.05779699,-0.005110741,-0.0007291683,-0.093697704,-0.030413285,0.023211485,0.043272663,-0.012164934,0.034907002,-0.020178623,0.12993515,0.06822259,-0.040582687,-0.020509616,-0.0078850025,-0.08220879,0.06438557,0.05103636,-0.016309332,0.046490148,0.0030842929,-0.09754105,-0.06442942,0.046232637,0.05213389,0.006240806,-0.035540674,0.03519927,-0.0055945585,0.08494691,-0.05386384,-0.07806406,-0.025390033,0.07795582,0.010244066,-0.117221214,0.023292262,-0.0012927823,-0.010873088,0.087687634,0.029771818,0.013439381,0.07609506,0.012738219,-0.048952367,0.09693972,-0.030316243,0.040070508,-0.016661895,-0.054710038,0.00034704222,0.020619659,0.004566155,-0.015692148,0.051211633,-0.02620903,0.15610558,-0.025115045,-0.041351277,0.027900709,0.00052681507,0.0039755986,0.08130057,-0.012961595,-0.07005838,-0.039050367,-0.07274668,0.03353852,0.022331646,0.014642764,-0.018078055,-0.008340158,-0.06577605,0.016844613,0.0005814318,0.026688201,0.0479508,-0.07262892,0.030681446,0.014922466,0.030132664,-0.058877345,0.035400152,0.033585943,-3.1424644e-08,0.05119328,-0.009997782,0.10984778,0.02088168,-0.072463356,-0.031692456,-0.029012376,0.12799801,0.005888258,-0.044813994,-0.034493327,0.09802432,0.0042402283,0.046140898,0.04718061,-0.027182737,0.014402977,0.027301,-0.006770564,-0.05965182,-0.07046283,-0.027672146,-0.05222478,-0.046852842,-0.041455183,-0.090595394,0.082101844,-0.0072256415,0.03839686,-0.083602525,-0.057524305,0.009303428,0.014405429,-0.055794578,0.019525198,0.008556271,-0.0015773755,-0.05967526,-0.017976178,-0.00072091835,-0.016855279,-0.045790788,-0.10243826,0.0024941724,0.1326247,-0.06902408,0.058049537,-0.022186091,-0.033390302,0.01459169,0.096146315,-0.011094063,0.115566395,-0.06354562,-0.11354071,-0.038651165,0.012767596,0.015654195,0.06694677,-0.026758898,0.023001878,-0.017348198,0.15409398,0.03801052 +1.3.8.5,"A flavoprotein (FAD). The mammalian enzyme catalyses an oxidative reaction as a step in the mitochondrial beta-oxidation of short-chain 2-methyl fatty acids and participates in isoleucine degradation. The enzyme from the parasitic helminth Ascaris suum catalyses a reductive reaction as part of a fermentation pathway, shuttling reducing power from the electron-transport chain to 2-methyl branched-chain enoyl CoA.",384,1.0,-0.069739,0.013292635,-0.09355014,0.067224115,0.11757994,0.013880036,-0.0781345,0.04152684,0.03850491,-0.05886225,0.025332807,0.021373503,-0.08952007,-0.06732596,-0.075317144,0.00865921,-0.050204754,0.0027706474,-0.05162844,-0.081360236,0.03376632,0.010448264,0.049923066,-0.050584067,0.022808446,-0.030768009,0.010453353,-0.09654327,-0.03751949,-0.030424763,0.07423349,-0.004743311,0.041757505,-0.0120807905,-0.069474705,0.09829056,0.0680402,-0.028739892,0.01071425,-0.0058526616,0.04306628,-0.014961903,-0.0037866712,-0.0052887327,0.026556911,-0.018994955,-0.034175903,0.024793843,-0.008862628,0.04040632,-0.028761238,-0.038214177,-0.097339906,0.04900366,-0.002353758,0.058766723,-0.035713077,-0.102071464,-0.042209703,0.029220393,0.019405367,-0.009193994,-0.012967231,0.0043670135,0.02718623,-0.104569085,-0.03343629,-0.047851354,0.00988683,-0.0128014535,0.00459097,-0.06983216,-0.068175994,0.021837037,0.022831934,0.02589377,-0.0847595,-0.05797529,0.06711424,-0.004897146,0.047110777,-0.035577465,0.0529903,0.038497645,0.06808802,-0.040856183,-0.010490276,-0.034758586,-0.03326928,0.089020856,-0.016954103,0.003007396,0.019107133,0.033091184,-0.064706706,0.06524291,0.06712073,-0.013931926,-0.06746737,-0.0148474425,-0.054310117,0.014104035,-0.0077040037,-0.07791576,-0.039140128,-0.04697007,-0.062343374,0.08052965,0.012345088,-0.024999743,-0.0020319105,-0.026187604,-0.001622171,-0.038506404,0.035168175,0.07908795,-0.0069322223,-0.06932526,-0.052076727,-0.02366879,-0.016072951,0.09365833,0.057036657,0.093727425,0.021411613,-0.011366455,-0.075072,3.5567267e-33,0.0444334,-0.0284176,-0.048905775,0.003292733,0.02231778,-0.026955476,-0.05800938,0.0036135477,0.058603898,-0.0023542887,-0.014047578,-0.012799345,-0.0042554284,0.0041702767,0.07351924,-0.028413547,-0.012776541,0.006790955,0.13742323,-0.11177202,-0.0042793592,-0.008806053,0.028110448,0.004019669,0.047849335,-0.012486124,-0.06574842,0.024406422,0.012517234,0.04144991,-0.0032819354,-0.07565973,-0.08992236,-0.033800263,-0.04277724,0.052392107,-0.08557856,-0.09603234,-0.11618155,0.088037424,0.0020362781,-0.025741048,-0.026672067,-0.04175173,0.006809519,-0.030312102,-0.042174477,0.09135537,0.026154619,0.10019417,0.038122747,-0.053016797,0.171684,0.0887572,-0.05018641,0.045263585,-0.03398587,-0.021176375,-0.007189687,0.008405585,0.02529384,0.05890209,-0.018061707,0.09570366,-0.0480694,-0.029986458,-0.040610015,-0.046865743,-0.034000564,0.1369033,0.01498836,-0.014328887,0.059458088,-0.02031353,0.052062906,-0.025298696,-0.05485163,-0.019804806,-0.014261666,0.007704444,-0.0134425545,0.026530372,-0.026797216,-0.004052152,0.008921739,0.056057755,-0.04185111,-0.02190397,0.06473589,0.0134705715,0.026845757,-0.04398439,-0.010736974,0.022536036,0.062473927,-3.255579e-33,0.04825564,-0.12957676,0.024058592,-0.03305092,0.0069812797,0.019638801,0.053716056,-0.0044054934,0.004072417,-0.07507535,-0.014843313,-0.03786279,-0.024851872,0.006046657,0.08912711,-0.017064748,-0.028901944,0.04788613,0.058661524,-0.01353926,-0.05079642,0.06250682,0.027232755,0.09468262,0.037866462,-0.009767574,-0.009960118,-0.0076083667,0.013642885,0.031134777,0.013597962,0.03761043,-0.030972006,-0.0022080976,-0.016645685,0.07277737,-0.03818814,0.057305332,0.015221991,0.04172734,-0.0018642069,0.043685857,-0.011259183,0.022972248,0.09401175,0.021560589,-0.06836427,0.02109795,0.05889429,-0.0666573,0.09019689,0.02303148,-0.018072534,0.018248018,0.058161795,0.053213697,0.018177295,0.050640583,0.05518436,-0.06719182,-0.03428369,-0.096467555,0.05665379,-0.0119344825,0.088690214,0.05254998,0.022226656,0.09577366,-0.034705553,0.037973806,0.104889445,0.0019496212,-0.03550605,0.09708977,0.035600636,-0.039875977,-0.0058925524,0.04500836,0.0022134935,0.028713463,-0.0020262913,-0.011752978,-0.008117189,-0.015691526,-0.08401326,-0.13817881,0.0012542167,0.10882483,0.011841634,0.041848883,-0.02516324,-0.00039565965,-0.033079363,-0.008362491,0.0621816,-4.0064265e-08,0.0021491088,-0.019629199,0.021277247,0.017188713,0.07098425,0.05643089,-0.018274033,-0.040527113,0.027980657,-0.065714166,-0.055662613,0.14454076,0.029409494,0.015915196,0.02153795,-0.017417409,-0.029221682,0.06067877,0.0019740998,-0.038336758,-0.08504981,0.043931425,-0.103282146,0.036300212,-0.0049906643,-0.04987274,0.037773263,0.01730437,0.07490994,-0.037196223,0.025562601,0.046493717,0.056762766,-0.0072416877,-0.054734617,0.003913918,0.031334706,-0.068762094,-0.011159135,0.05177833,-0.08239377,0.011624448,-0.0015486344,-0.04296154,-0.04603368,0.0026857469,0.05580068,0.019057583,-0.080974385,0.0151045965,-0.018791847,-0.0155578125,0.008444991,-0.016019776,-0.08117561,-0.051468577,-0.019489078,-0.07963894,-0.0154507635,-0.102758214,0.06648151,0.041250616,0.15686162,0.009777961 +1.3.8.6,"Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 7.2.4.5, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA [EC 1.3.99.32, glutaryl-CoA dehydrogenase (acceptor)].",384,0.99999994,-0.11915582,-0.046172846,-0.05023479,-0.065600164,0.10855599,-0.010305345,-0.1411681,0.0033401104,-0.0106470715,0.018958306,-0.029987546,-0.046014663,-0.05321224,-0.0022407244,-0.0650311,0.0042260448,-0.07603652,-0.023951625,-0.0106993755,-0.021752706,0.031518836,-0.004732662,-0.055051316,-0.03753394,0.07133335,0.05868304,-0.002365244,-0.045349594,-0.086644016,-0.01769982,0.040962946,-0.012836718,0.038580343,0.011921529,-0.022822293,0.09261616,0.0013326877,-0.051711615,0.079126365,-0.022241164,-0.047484256,0.012682397,-0.010642238,-0.030546866,0.003827094,-0.034577575,0.004178957,0.05001074,0.0055859764,-0.069162056,0.010928868,0.025440514,-0.11793906,0.06821009,0.023516344,0.01708367,0.02967382,-0.06013156,-0.007667305,-0.027142532,-0.006560934,-0.05282527,-0.015366818,0.002229012,-0.0004245331,-0.09126187,0.03667533,-0.05119706,0.028137248,-0.05202465,-0.056231182,-0.056052495,-0.013573288,0.008118571,-0.031649422,0.046182696,-0.0281635,-0.061602898,0.0558148,-0.045533754,0.028742872,0.044583306,0.08860072,0.10945338,0.06501161,-0.07278534,-0.030593876,-0.02573465,0.035500742,0.028893465,0.06214248,-0.009125809,0.030577363,-0.02214788,-0.0850327,0.07037709,0.054283597,0.075822204,-0.010345505,-0.040613167,-0.042236213,0.040196918,-0.024113731,-0.07842219,-0.028254546,-0.02611599,0.023674384,0.16657954,-0.011762381,-0.04032746,-0.024299836,0.038445327,-0.00020956229,0.031819746,-0.0088093,0.0826542,0.06507815,-0.09321356,-0.03172784,0.010219002,-0.022022223,0.0046503176,0.08222247,0.032435354,0.018481392,0.030533733,-0.093125105,2.8431902e-33,0.05791344,0.00688648,-0.0032383853,-0.066421404,-0.017222561,0.01790067,-0.103748515,0.11568807,0.033181615,-0.0125818495,-0.060921438,-0.006437289,0.054698605,0.018909888,-0.029152181,-0.009040268,-0.03293144,-0.049220353,0.07837435,-0.051442638,0.023853157,0.06402029,-0.017655589,0.0110512255,0.029109908,0.0012507605,-0.015408419,0.070108786,0.013769517,0.0050087087,0.068284705,-0.089970164,-0.04126627,0.0192363,0.021344403,0.03160088,-0.10268149,0.0045621796,-0.06236362,0.0504133,0.0058799367,0.041778497,-0.021733368,-0.07315439,0.018389385,-0.0301621,-0.045667827,0.06504598,-0.025781935,0.1059819,0.07508026,0.015398116,0.0694857,-0.024177155,-0.05970216,0.07411839,0.00094355305,-0.02879073,0.09618543,0.049536612,0.053131778,0.068736546,-0.042613775,0.028031124,0.032324526,0.0207004,-0.023036545,-0.009466821,0.008768415,0.11945369,-0.055153355,-0.014146654,0.069576554,0.041283518,0.054052982,-0.044112395,0.00064088247,-0.026437433,0.037216987,-0.03311995,-0.016376158,0.0006994584,0.006950917,-0.037953988,-0.043833554,0.022879483,-0.059052512,-0.047627322,0.004708519,0.014738317,0.005293497,-0.10111472,-0.033511475,0.0023188752,0.021836817,-2.9390125e-33,0.12989658,-0.10999916,0.01887215,-0.094666995,-0.00677998,0.10535161,0.06128782,-0.061776657,0.053059854,-0.03801748,0.08119008,0.029714106,-0.005809322,0.024853935,0.04993308,0.030845592,-0.031526364,0.008406885,-0.029058464,0.010345347,0.03972765,0.08864359,0.031774253,-0.010642945,0.056374297,-0.027031528,-0.01484936,0.015912976,0.07358303,0.016053338,0.0053222408,0.01540003,-0.019594757,-0.005304136,-0.06306435,0.024902467,-0.06094737,0.013031961,-0.01879756,0.028198866,0.029191257,0.0026023642,-0.014943483,0.08924629,0.05676536,0.014609284,-0.12655014,0.0054981015,0.034314044,-0.02633629,0.04653238,-0.018188013,-0.04896338,-0.011630229,0.086619474,0.07339201,0.05269246,0.01125748,-0.023089353,-0.013680327,-0.07610954,-0.07550161,0.024584476,-0.06393586,0.060792245,0.04880551,-0.009797788,0.06924529,-0.0025993441,-0.010983839,0.057481047,0.0023336923,-0.026858961,-0.026633553,-0.033957753,-0.05713274,-0.027966829,0.035351686,0.00512887,0.03461169,0.008742109,0.00762194,-0.0284604,5.136711e-05,-0.069925755,-0.10540247,-0.015126931,0.08458909,-0.0038517546,0.04642656,-0.040380917,0.02106835,0.042375043,0.038479675,0.08701017,-4.2354063e-08,0.00074184284,-0.034517027,0.07064313,0.039731696,0.058664087,0.08362464,0.0055209077,-0.03205076,-0.008601198,-0.040443532,0.040818326,0.12309559,-0.04450247,-0.030232657,-0.0009181231,0.011736802,-0.08040953,-0.031968225,-0.016285608,0.01630269,-0.051196028,-0.0013442193,-0.1025345,0.076934464,0.035451487,-0.05928931,0.05688511,-0.07703176,-0.012605365,-0.0107284365,-0.023089444,0.029433008,0.02023612,-0.062127452,-0.05020856,-0.052528206,0.018075906,-0.061510872,-0.026675044,0.04769285,0.034333173,0.03767605,-0.0759203,-0.0097732665,0.058393884,0.04561825,-0.0048960904,0.021821588,-0.0906872,0.056362648,0.07905288,-0.012385688,-0.0030324522,-0.0053089173,-0.13134278,0.06424768,-0.03622958,-0.09031505,-0.036418546,0.008318327,0.08156622,0.012196359,0.15605167,0.010264473 +1.3.8.7,"Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds [2]. The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.",384,1.0,-0.040384997,-0.054988068,-0.058337107,-0.0074011264,0.07291449,0.0824634,-0.1676281,0.023060896,-0.01473034,-0.037287705,0.04236345,-0.053250104,-0.107818425,0.019657163,0.0012389619,-0.0070388312,-0.05329693,-0.05209074,0.00018835273,-0.10131743,-0.06383857,0.0018766694,-0.019350283,-0.011525871,0.038131777,-0.046075903,0.050258897,-0.06267106,-0.019949406,-0.051792677,0.016557857,-0.061330937,0.029868886,0.0012382308,-0.0049356213,0.03472256,-0.021428863,-0.057411112,0.080619365,0.04516943,-0.005291321,-0.027772795,0.017772356,-0.0019587493,0.01950912,-0.09602065,-0.022390883,0.047826488,0.05639548,0.0027347978,-0.04122136,-0.025957426,-0.04125433,0.038936403,-0.012198453,0.010981736,-0.06965803,-0.07345683,0.014788958,0.032109503,-0.026478672,-0.061840918,0.017421113,0.047575828,0.0070387125,-0.06616373,0.016143791,-0.0873162,-0.0015374834,-0.025362683,-0.08151823,-0.07981727,-0.028234184,0.010373916,-0.023332227,0.026827378,-0.09666753,-0.09576196,0.06063626,-0.057414632,-0.008993794,-0.0043372833,0.0712862,0.06564056,0.03786144,-0.044091538,-0.0031857383,-0.0030759259,-0.05590118,0.095774546,0.05215453,-0.021272475,-0.0005072533,-0.013753605,-0.043215998,0.037802216,0.08849732,0.04814874,-0.02918754,-0.045254417,-0.0029473135,0.06267191,-0.034807865,-0.02643737,-0.039405648,0.01780651,-0.022631241,0.09845162,-0.02011298,-0.0050680926,-0.01414104,-0.0027920706,0.030369394,-0.0011801076,0.02420955,0.055119734,0.02488625,-0.09493705,0.007134109,0.027377002,0.0030626657,-0.02551553,0.06918195,0.033915397,-0.013201117,0.010085846,-0.06089117,2.0276908e-33,0.062190164,0.033334833,-0.025301985,-0.014718688,0.030500328,-0.020175984,-0.109313644,0.08288275,-0.03314876,0.05473699,0.010849145,0.021350183,0.043237712,0.027590219,0.051999744,-0.015661208,0.046190836,-0.018573256,0.07329084,-0.071236774,-0.027071135,0.006526761,0.04093135,-0.04339181,0.07680342,0.010744565,-0.052609313,0.09454229,-0.014438562,0.012895959,-0.04213542,-0.03651496,-0.019994501,0.045762114,0.0024674234,-0.011335677,-0.05592338,-0.04485029,-0.05816951,0.039800096,0.1077968,5.7326484e-05,0.012870071,-0.062357306,0.020275768,-0.056421094,-0.07372834,0.052949075,0.004530351,0.112530634,0.09253856,0.027057778,0.06700633,-0.008602017,-0.020119268,0.019859502,-0.07663836,0.00686777,0.015393159,0.046685454,0.0071136532,0.0699127,-0.080929846,0.05696954,-0.028564261,-0.023007058,-0.13630834,-0.044200007,-0.09248704,0.072670616,0.010429834,-0.039395485,0.06351705,-0.025513284,0.042159665,-0.008981431,-0.051379997,0.025743727,0.0019230997,-0.06817726,-0.0064428486,0.042728946,0.0402908,-0.011543592,0.013917662,0.040596876,-0.025280848,-0.039295245,0.037765183,-0.021091098,-0.022639904,-0.08517387,-0.017316112,0.02164715,0.065865375,-3.6254637e-33,0.119627245,-0.10346184,0.051660065,-0.1451658,0.008071833,0.06795573,0.05987909,-0.067670554,0.07135303,-0.06070065,0.05267363,0.028088069,0.003684659,-0.047034837,0.0876905,0.0054156245,-0.0012985645,0.029961616,0.0012532026,-0.051266827,0.00981955,-0.005590377,-0.016517732,0.09209259,0.03781489,0.03384993,-0.012418166,0.010216014,0.07014792,0.06536322,-0.061567977,0.040740423,0.0015515317,0.0049915123,-0.039993647,0.004416788,-0.09530385,0.05416526,0.0049767448,0.053064443,0.030205132,-0.007063246,-0.046800207,0.030424245,0.08552709,0.0060304953,-0.025246702,-0.02980783,0.0028779807,-0.086915664,0.018933443,-0.049267773,0.0026999316,0.018526396,0.06357664,0.11347705,0.00935321,0.02259672,0.099535614,-0.12796499,-0.022523833,0.020271223,0.006634818,0.004136183,0.060453307,-0.00303288,-0.05573635,0.013931517,-0.029837837,0.030319832,0.05987305,0.06350327,-0.048600912,0.04362254,-0.004334256,0.0020212086,-0.0069824215,-0.031006228,0.0023628809,0.0011483673,-0.016787367,0.02003046,0.00061271916,-0.004064011,-0.049658038,-0.03146033,0.020323005,0.050875593,0.058400847,0.033664618,0.003660869,0.02131629,-0.003948686,0.03256476,0.066056915,-4.1777103e-08,0.04264737,-0.054976765,0.059054166,-0.019851036,0.0094151655,0.069479875,0.06253194,-0.047704555,0.0110927485,-0.061546754,-0.06287773,0.1269855,0.06510228,0.049672436,-0.03243754,-0.02563206,-0.089023985,-0.006529858,0.0034449715,0.015649337,-0.09073403,0.009686248,0.03786664,0.060890615,-0.041011058,-0.07981051,0.0028480573,0.043300025,-0.034694497,0.047806207,-0.027149163,0.045390192,0.023422386,-0.04321407,0.023357423,-0.03272857,0.089997694,-0.059774544,-0.09019542,0.06872406,0.049272187,-0.06676029,-0.05451986,-0.040049244,0.043076918,-0.02209774,-0.017712874,0.02090857,-0.024223605,-0.0020565733,0.0069590495,0.03175339,-0.07671144,-0.018599058,-0.025871078,-0.074170195,-0.050699063,-0.10416149,-0.05968221,-0.07882303,0.09295038,0.02462678,0.19546215,-0.038396753 +1.3.8.8,"Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively [2]. The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.",384,1.0,-0.0017486386,-0.05908847,-0.052023716,-0.023371806,0.06544417,0.08249094,-0.17427713,0.047690466,-0.0013645866,-0.026177198,0.037318118,-0.05718114,-0.087529466,0.050325446,0.0048552747,-0.004687329,-0.019015659,-0.06426373,0.0053295707,-0.09865711,-0.058695458,-0.02876254,-0.019998373,-0.018571045,0.028000407,-0.07048896,0.037902273,-0.07815828,-0.033245638,-0.065241955,0.0010678304,-0.06365091,0.030698154,-0.0065497314,0.00073654874,0.027004337,-0.03614088,-0.060651194,0.09316869,0.04846284,-0.0062543964,-0.011381359,0.011826673,-0.0049129752,-0.002643712,-0.09233971,-0.005438886,0.027267696,0.049041867,0.013223076,-0.019039895,-0.011666165,-0.04231659,0.047663994,-0.021549653,-0.013686573,-0.078500554,-0.061080802,0.02466064,0.026222654,-0.024594981,-0.055607624,0.028723909,0.028749261,0.0010773032,-0.06672763,0.017833348,-0.08127724,-0.0075243795,-0.018698284,-0.081836745,-0.09107556,-0.019459246,-8.2050356e-05,-0.02365049,0.0039005731,-0.06565677,-0.10252902,0.05484051,-0.06371455,-0.01876523,0.0105904015,0.05631136,0.0336138,0.034680773,-0.031140588,-0.014398714,-0.0018827093,-0.03686272,0.09783224,0.046265773,-0.0054849084,-0.013007912,-0.02819995,-0.017775835,0.04120777,0.08738079,0.06604551,-0.0224158,-0.04907801,0.024920885,0.06873891,-0.024963204,-0.03002782,-0.03391577,0.028781008,-0.00075090985,0.09658853,-0.0093952315,-0.000117884745,-0.018095134,-0.0050599286,0.006158688,0.0049473075,0.03443802,0.085272364,0.044930417,-0.09475128,-0.0119837085,0.040778004,0.025274774,-0.02646885,0.1001859,0.02579581,-0.0051849913,0.032395408,-0.03795274,1.9340216e-33,0.051489104,0.04234824,-0.0216262,-0.017831475,0.034609564,-0.009178798,-0.10820649,0.10455563,-0.03704008,0.044701144,-0.004619765,0.019098097,0.048433404,0.03720901,0.040312286,-0.016772242,0.07725821,-0.01728114,0.06610917,-0.06418245,-0.02550223,-0.015291281,0.035345994,-0.0094137555,0.08415982,0.0026176057,-0.03879401,0.087539755,-0.013552546,0.0004708912,-0.046461236,-0.042208593,-0.017710278,0.045025192,0.018398343,-0.015391376,-0.048384994,-0.018181557,-0.04362148,0.02612537,0.11470285,-0.0030287807,0.032070246,-0.07789576,0.028697312,-0.053372428,-0.075536996,0.053861972,-0.0063178446,0.10074835,0.097092226,0.025906302,0.08455568,-0.020557769,-0.016182292,0.03838487,-0.07704688,0.004512924,0.025177874,0.048078366,0.012110631,0.06904619,-0.08165624,0.07627365,-0.02529776,-0.005166901,-0.15195003,-0.030571371,-0.08208239,0.06637729,-0.0019883977,-0.04088907,0.0669798,-0.026438827,0.066194385,-0.011206794,-0.06538863,0.022117794,0.019597782,-0.052841622,-0.03777021,0.034796674,0.04047393,-0.016424624,0.010502385,0.020871446,-0.028573347,-0.035380356,0.043538835,0.008254351,-0.012505667,-0.08225637,-0.00754181,0.014469596,0.069779485,-2.915759e-33,0.11801281,-0.089215286,0.041596256,-0.14112175,-0.0044040848,0.07835984,0.042589836,-0.06595412,0.07153455,-0.049542863,0.06320183,0.0354015,-0.007037291,-0.04365593,0.080664866,0.03537563,-0.032171085,0.04960708,0.008765408,-0.033655297,-0.003940376,-0.016605884,-0.0011468248,0.08168001,0.06600694,0.03402356,-0.008374692,-0.0096063055,0.090283014,0.060101915,-0.06808983,0.0512437,0.013839827,0.021738974,-0.029519388,-0.0012753115,-0.08336598,0.041873347,0.0032488827,0.05390956,0.029980222,-0.006954685,-0.059787516,0.023906346,0.06872795,0.02871736,-0.049309112,-0.046094228,-0.013913491,-0.074667834,0.007875862,-0.047868613,-0.0072562057,0.012179956,0.06824523,0.119138055,0.010403203,0.03332549,0.11134972,-0.13160054,-0.014363418,0.035941724,-0.0075274697,0.007922811,0.0669052,-0.02343159,-0.08114751,0.030842567,-0.042152856,0.03523561,0.04986059,0.061460443,-0.035526734,0.026474077,-0.008266774,0.008683992,-3.992543e-06,-0.046612855,-0.003222229,-0.005036172,-0.03302355,0.026794855,0.013664587,-0.017260643,-0.03922874,-0.043360278,0.025702504,0.056596074,0.053369753,0.03484176,-0.0010837072,0.001811249,-0.015761496,0.03749621,0.063902944,-4.520923e-08,0.0273476,-0.030198954,0.04793879,-0.031271532,0.0023500882,0.07954932,0.057067804,-0.037563168,0.0069352016,-0.053200234,-0.06220569,0.10299583,0.05974205,0.034802213,-0.015501018,-0.04222391,-0.089905575,-0.023214774,0.013713186,0.031875204,-0.08324606,0.014166579,0.014398571,0.049130697,-0.044714358,-0.070511475,0.0007090851,0.052311514,-0.04847969,0.031249491,-0.040883753,0.04501681,0.016708912,-0.030416358,0.022742938,-0.04844041,0.06889031,-0.054374397,-0.09879824,0.09836093,0.06668637,-0.08859706,-0.061378155,-0.038844977,0.054771826,-0.036742236,-0.022921415,0.022148993,-0.005140207,-0.012299948,-0.0063957726,0.035001878,-0.0674636,-0.029948404,-0.0011621078,-0.053389724,-0.049550127,-0.10326812,-0.0664837,-0.09991024,0.08836569,0.022142723,0.15300152,-0.035176266 +1.3.8.9,"Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.",384,0.99999994,-0.05889957,-0.08354911,-0.06872425,-0.026685238,0.13173693,0.061419904,-0.19185744,0.015516689,0.017781975,0.009713821,0.050463356,-0.037260935,-0.11579481,0.017406223,0.02918042,0.0013572266,-0.04146903,-0.05090773,0.024131637,-0.063990355,-0.020220779,0.018464992,-0.00060497085,-0.007782231,0.022480918,-0.054743033,0.014004135,-0.09096209,-0.025445705,-0.06542513,0.03503141,-0.016960504,0.05085037,0.013391488,0.01518564,0.03487591,-0.0043916046,-0.0735869,0.07262731,0.043354306,0.026052792,-0.05448368,0.07736174,-0.02433615,0.013986507,-0.10702899,-0.041755054,0.062191583,0.040607926,-0.01350167,-0.03639357,-0.02798122,-0.052356288,0.042557012,-0.00012352245,0.019062035,-0.025759071,-0.04776074,0.019930003,0.086317524,0.009532175,-0.038933676,-0.024263855,0.035467796,-0.0029616044,-0.07188768,0.03557071,-0.081372425,0.010999372,0.009279553,-0.06158743,-0.0640606,-0.056510612,0.023101306,-0.026140247,0.03627931,-0.052721962,-0.0709806,0.031087823,-0.07137254,0.0022390622,0.041662566,0.08258766,0.042762224,0.04102731,-0.04353433,-0.025965014,-0.02953977,-0.029457238,0.07513574,0.04929034,-0.030447286,-0.0021267296,-0.002863094,-0.066937916,0.07304011,0.10741974,0.013434544,-0.024220774,-0.058392536,-0.0167096,0.07603719,-0.03204884,-0.05587951,-0.073037095,0.027148755,-0.011912405,0.08255667,-0.019879797,0.0037934894,0.0030100546,0.040158115,0.00023661535,0.0015500131,-0.0019944774,0.03195664,0.04088331,-0.08115703,-0.0034361926,0.059950497,-0.0074601434,-0.04495055,0.0568481,0.052193154,0.002327807,0.035853133,-0.046105966,2.3656205e-33,0.065082386,0.014901781,0.028602177,-0.026595658,0.024034418,-0.04419404,-0.11400957,0.044280782,-0.07457871,0.07515116,0.0461998,0.03153934,0.034278575,0.07723304,0.058073472,-0.01845792,0.034048367,-0.03805522,0.0492123,-0.07815197,-0.007503283,0.02987302,0.021908958,-0.010303985,0.09891363,0.027875874,-0.018085876,0.09021645,-0.0007610413,0.010319956,-0.0051429705,-0.020064577,-0.050053433,0.03882303,0.003186943,-0.019250557,-0.06330032,-0.023472661,-0.046156716,0.03452451,0.079790555,0.019864354,-0.028326657,-0.101911075,-2.4859528e-05,-0.08340114,-0.023049569,0.06361579,0.012603296,0.09582262,0.05193817,0.018909713,0.04658862,0.033122305,-0.03829794,0.06931408,-0.064064436,-0.026121859,0.018457945,0.01694935,0.017811164,0.020320427,-0.06285959,0.0354702,-0.042503897,0.027380398,-0.117357776,-0.043655194,0.0009543735,0.039677408,0.024387322,-0.00019774435,0.058875937,-0.0028461684,0.068899795,-0.0070460853,-0.04961273,0.04813719,0.027616289,-5.6687564e-05,0.02264535,0.018838044,0.06713292,-0.002181839,-0.015990656,0.016400915,-0.061654493,-0.045829132,0.024290025,0.018989958,-0.028856888,-0.07491741,0.0409898,0.021258084,0.030322814,-3.5634145e-33,0.119981594,-0.08501999,0.0538725,-0.15496184,-0.009063941,0.036320392,0.019378893,-0.02067217,0.024303524,-0.049408656,0.052620165,0.041577738,-0.022882119,-0.06302605,0.059260655,0.05325849,-0.032783095,0.030098509,-0.0022488402,0.0028279775,0.004749421,0.018046442,0.041153032,0.08511881,0.064503305,0.02766924,-0.013186432,-0.0037342892,0.045514252,0.06354988,-0.05093025,0.052829474,0.0032673802,0.018424489,-0.08600363,-0.012693175,-0.09839858,0.0746035,0.014281173,0.078899756,0.020969525,-0.011848968,-0.02054179,-0.042655963,0.07619521,-0.008831144,-0.08371343,-0.045882,-0.029843636,-0.08807379,-0.0018063678,-0.0072622807,-0.013693527,0.021058232,0.07238411,0.08416318,-0.009986563,0.054003675,0.074615434,-0.1247006,-0.018870933,0.031795703,-0.023423819,-0.029380843,0.0978554,0.027672859,-0.064508185,0.011011605,-0.023318036,0.02837536,0.048555437,0.06945047,-0.017930722,0.021694014,-0.016340714,-0.043132026,-0.03996434,-0.087737516,-0.05360227,0.015761279,-0.0065289596,-0.009818577,-0.062172577,-0.030347046,-0.086166285,-0.022298776,0.040044565,0.049757123,0.033473738,0.076830246,-0.042574346,0.019234654,0.0033999407,0.04799567,0.07130063,-4.3127564e-08,0.0265047,-0.031615634,0.033273168,-0.022719322,-0.021675806,0.07373458,0.054737,0.00028920325,0.03159581,-0.05074214,-0.035605468,0.10529986,0.09249199,0.055210534,-0.021903213,-0.08252319,-0.060694005,-0.05672562,-0.009086046,-0.016575411,-0.06751393,0.03126033,0.023543578,0.06820558,-0.06751922,-0.06999116,0.006107292,0.0059056776,-0.026391385,0.031546813,-0.063146286,0.07504494,-0.005587403,-0.001769849,0.006886572,6.0769078e-05,0.06814053,-0.07661766,-0.06918069,0.13134162,0.030295493,-0.05245446,-0.08314015,0.0015035677,0.040094383,-0.023214618,-0.021107698,0.03528674,-0.011170645,0.0011024389,0.025964322,0.022774387,-0.10714937,-0.03640878,-0.04012603,-0.010081822,-0.04579568,-0.08679944,-0.035959333,-0.056562483,0.08111486,-0.052616168,0.14027008,-0.02768685 +1.4.1.23,"The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].",384,0.99999994,-0.023720289,-0.01899828,-0.1015903,-0.04447249,0.013068488,0.079513706,-0.11850795,0.029237736,0.0421349,-0.049607787,-0.008988611,-0.02831925,-0.028587531,0.05077678,-0.057696454,-0.017639942,0.0058794534,-0.057258245,0.082326606,-0.01924222,0.013291698,0.06467419,0.033610336,-0.050807986,0.112116784,0.06077543,0.013353604,0.015474112,-0.06874434,-0.030723283,0.014792656,-0.0049664956,-0.021441849,-0.082979105,0.08822166,0.1136239,-0.025080217,-0.046150334,0.015706087,0.05259297,-0.0021521777,0.024493305,-0.0993485,0.06853827,-0.030664632,-0.028931059,0.017641872,0.06414969,0.017550716,-0.07160803,-0.05262276,-0.018894907,-9.362743e-05,0.016800955,-0.0012274521,-0.011507104,0.02153404,0.011132744,-0.041696977,-0.10631409,0.029527657,-0.056816466,0.05596331,-0.010180997,-0.0026868952,-0.004466505,0.06667048,-0.042130206,-0.01162912,-0.030121466,-0.11998797,0.007612886,-0.031684622,0.07719056,-0.03851697,0.054246806,-0.040944375,-0.062391654,0.06027429,-0.0029844963,0.022498107,-0.0070924666,-0.03238336,0.05700835,0.04772317,-0.00963924,0.028154561,0.024972225,0.011838298,0.057259824,-0.0056139845,-0.008757745,-0.036844645,0.0020280203,-0.08478248,0.018174194,-0.067941904,0.033826746,-0.07154824,-0.063911304,-0.038113244,0.0937883,-0.023562098,0.036360707,0.008783397,0.04970733,-0.020001242,0.070085645,-0.049053572,-0.07843446,0.019837614,-0.015888214,0.03725554,-0.036610987,0.019543178,0.075689316,0.07297894,-0.08273309,-0.11840651,-0.017762402,0.015077869,-0.018229164,0.06406629,0.03816202,-0.046723407,0.05179213,-0.08999516,1.9526986e-34,0.06968562,0.024833083,0.06493371,-0.043146666,0.0658444,0.023663629,-0.09204295,0.077866234,0.010961517,-0.052574795,-0.05387243,-0.07886749,0.067641534,-0.043310773,0.058810722,0.035145752,0.035967283,-0.031776275,0.020878717,-0.023274712,0.034029838,0.022135504,-0.00084027677,0.025997244,0.0178557,0.057208534,-0.04450846,0.047711566,0.022795603,-0.026477136,0.008404872,-0.100590475,-0.09098342,0.031179594,0.075430416,-0.0048153275,-0.04040784,-0.07139544,0.03541939,0.020742685,-0.089127176,0.058873296,0.024692688,-0.016025674,0.013253069,-0.13345104,-0.02670743,0.04871942,0.011738799,0.0755207,0.047207795,-0.0065071434,0.08068878,-0.10214537,-0.043639295,0.056347042,-0.0046490435,0.072214924,-0.0055912235,0.0669246,0.053757954,0.036641173,-0.01811724,0.051159065,0.010117132,0.038438495,-0.0761687,-0.038202994,0.036760405,0.046486802,-0.012325262,0.057108473,0.046147253,-0.005314255,0.034286033,-0.04924579,-0.016020378,0.0010717968,0.0331746,0.028770268,-0.028349841,-0.09633778,-0.014468567,-0.05090651,-0.0077950563,0.088463336,0.029082011,-0.016730545,0.044702362,0.07568607,0.02344434,0.018116089,-0.03569906,-0.036431752,0.08059196,-1.40134355e-33,0.09978112,-0.053150266,-0.0005213173,-0.070074566,-0.05840208,0.12749045,-0.025100056,-0.06711311,0.00913673,-0.08098282,0.110652484,0.017527204,-0.0003146245,-0.048569378,0.02009004,0.00866415,-0.053780258,0.071014225,-0.046355836,0.017692944,0.009276104,0.11962342,0.025444495,0.013695866,0.0039959187,-0.048187554,-0.004164169,0.050970927,0.0021682938,0.012047934,0.05697772,0.03061788,-0.074344836,-0.050181605,-0.011883628,0.04326407,-0.06492798,0.0006398214,0.060382918,0.0141229415,0.07900834,0.025634624,-0.048427463,0.0673348,0.022684092,0.043931276,-0.08173058,0.0039156657,0.040341932,-0.07056741,0.028294386,0.037977718,-0.081193216,0.01688733,0.051264543,0.043191407,0.03999238,0.029695975,0.04521697,-0.027200792,-0.004223894,-0.008649245,-0.02211649,-0.013046924,0.10138785,0.026883679,-0.012083323,0.058474243,0.09990769,-0.03840557,0.05166072,-0.007796397,-0.014913376,0.026304381,-0.026247384,0.03491363,-0.10753301,0.055137947,0.026367769,-0.05188245,0.060004737,0.0057044877,-0.0077372105,-0.09614525,0.0071053286,-0.040094417,-0.0038466959,0.011811624,-0.033092104,0.057178076,-0.013465583,0.029654203,-0.012809578,0.035063524,0.0071094427,-2.8193925e-08,0.07821972,0.048617072,0.044649787,-0.05114225,0.020475449,-0.041255668,0.042278774,-0.094637655,0.046764124,0.04534387,-0.040109474,0.027917389,0.0020285114,-0.011955999,0.027293628,-0.038145866,-0.042323817,-0.00013299608,-0.006710758,-0.017294295,-0.090812795,0.0023470484,-0.104596436,0.03297444,0.023371516,-0.05582454,0.009925097,-0.048062406,0.103017725,-0.054637067,0.0540895,0.003328197,0.036788892,-0.054176155,-0.045410875,0.0078245755,-0.06077169,0.00197415,-0.049870256,0.06751356,-0.040173974,-0.07466461,-0.03776822,-0.014394626,-0.07134729,0.08011101,0.04896956,-0.05647643,-0.11081746,-0.010750849,0.08497609,0.003165646,0.04118414,-0.0179958,-0.07599337,0.06324647,0.042696357,-0.09494493,-0.04585414,-0.07290421,0.013156867,-0.060226645,0.065367594,-0.0150494585 +1.13.11.63,"Requires Fe2+. The enzyme cleaves beta-carotene symmetrically, producing two molecules of all-trans-retinal. Both atoms of the oxygen molecule are incorporated into the products [8]. The enzyme can also process beta-cryptoxanthin, 8'-apo-beta-carotenal, 4'-apo-beta-carotenal, alpha-carotene and gamma-carotene in decreasing order. The presence of at least one unsubstituted beta-ionone ring in a substrate greater than C(30) is mandatory [5]. A prokaryotic enzyme has been reported from the uncultured marine bacterium 66A03, where it is involved in the proteorhodopsin system, which uses retinal as its chromophore [6,7].",384,0.99999994,-0.07279647,-0.0748925,-0.08614148,0.007565098,0.07156574,0.022948248,-0.010911888,0.035508852,0.043361153,0.05389149,0.031722028,-0.08015956,-0.047930393,0.10948354,-0.031273436,0.004917968,-0.10246297,-0.038359363,0.056406487,0.011976744,0.036608454,-0.012275594,-0.054304253,-0.0031592534,0.0037200071,-0.014817403,0.075098984,-0.03360832,-0.07651561,-0.037815638,-0.0969451,-0.059377637,0.032151334,-0.041451354,0.07099215,0.07434462,-0.052194797,-0.1053566,-0.045263,0.055986322,-0.016221846,0.0035506377,-0.04299184,0.034750286,0.018698528,0.003313404,0.06213532,0.0093697375,0.05135188,-0.040691722,-0.09210315,-0.06643246,-0.03349666,-0.0042714793,0.0069169044,0.040213615,-0.08613435,-0.020945381,0.05968183,0.03242426,0.02701209,-0.03455998,0.089695625,-0.0107772,0.009857416,-0.042202376,-0.0019392452,-0.06656906,-0.019771006,-0.047391314,-0.028113965,-0.0043605114,0.03814729,0.0057990192,-0.061520446,0.040280215,0.026034798,-0.029078385,0.04498769,-0.033490766,0.025310587,-0.009370118,-0.007898014,0.063399084,0.085302174,-0.009673334,0.026302507,-0.0003894759,-0.048627593,0.07288678,0.0023272492,-0.0068512685,-0.06400581,-0.05425457,-0.04882461,0.003051292,0.010301052,-0.042601004,-0.0066205086,-0.040751167,-0.039152525,0.057731565,0.06470403,-0.11100951,0.011846702,0.0013824274,0.016890831,0.16883576,0.00024420352,0.028743356,0.07030074,0.07216695,0.026769016,0.013820321,0.04417717,0.11676787,-0.05030122,-0.05367927,-0.0035072113,0.090819746,-0.024563458,-0.02653813,0.056002676,0.05228687,-0.026251512,0.08265247,-0.07281951,3.5102377e-33,0.056603312,0.052976396,-0.011416805,-0.022589313,0.0259562,-0.038390826,-0.07730798,0.0009441889,-0.05779123,-0.06689482,-0.07073563,-0.056832884,0.04334758,0.041858476,0.051636178,-0.07172925,-0.0011002482,-1.44237865e-05,0.041504607,-0.00792327,-0.037701607,0.05112408,-0.017994113,-0.03365776,0.0599688,0.06771673,-0.03033824,0.007051273,0.024017788,0.014695171,0.08684375,-0.050295897,-0.052353006,0.040081766,0.11827546,0.012282127,-0.0032846476,-0.064261,-0.09133381,-2.5446154e-05,0.0521612,0.05892814,-0.030854432,-0.03543583,0.07752185,-0.05939003,-0.018538972,0.08411496,0.008891787,0.046205644,0.012576846,-0.010510991,0.061583374,-0.07690841,-0.05762338,0.023371046,-0.04972364,0.019565454,0.03841091,0.014802535,-0.039282713,0.08816064,-0.0072333235,0.05675066,0.01261182,0.0346563,-0.09285798,-0.06670148,-0.0632357,-0.0071677472,0.005878972,0.022056235,0.03554661,-0.02822236,0.006742424,-0.0037615295,-0.040634662,-0.0034863043,0.022977185,-0.035567336,0.00804694,-0.0013990242,0.0677643,-0.074450456,-0.014704258,0.040929254,0.034183122,0.021199733,0.02357835,0.04108493,0.11353233,-0.025928928,-0.022491954,-0.036126874,-0.03880143,-3.322705e-33,0.048001524,-0.1129216,0.087215535,-0.08497322,-0.03942439,0.092774116,-0.032802984,-0.08175632,-0.010044327,-0.0972397,0.00900387,0.02155624,0.03350753,-0.077596135,0.0028417553,-0.025826583,-0.036580727,0.06823074,0.008226291,-0.001000783,-0.049613237,0.04149949,0.07396296,0.024489846,0.05487354,0.06318186,-0.006643098,0.046951544,0.017061116,0.019278048,-0.0055080666,0.044368885,-0.04668485,-0.042907517,-0.05861793,-0.0007522107,-0.0855816,-0.011032047,0.083730265,0.09161749,0.031735968,-0.005604034,0.018312639,0.030096227,0.010310053,0.05860333,0.0024871067,0.020699006,0.009711567,-0.07593574,-0.07226257,-0.06640606,-0.04559464,-0.0073889606,-0.028865485,0.047551494,-0.001506026,0.079761006,0.03550277,-0.0066631013,0.021567676,-0.11594132,0.067642175,-0.0042552403,0.10221173,0.04321311,0.041377094,0.08423575,0.062043898,-0.07333145,0.11347292,-0.0047439225,-0.013903649,0.06014342,0.01597726,-0.016915042,-0.055136077,-0.0051857308,-0.0045730057,-0.00077769806,0.013631252,0.042088613,-0.05477586,-0.01295685,0.006482699,-0.05189867,0.07051931,0.058748055,-0.04027781,-0.02997145,-0.056158457,-0.013761213,-0.06273157,0.06042377,0.11681501,-4.663234e-08,0.098144375,-0.0057776715,0.0804473,-0.06207537,0.034802947,-0.048274834,0.024903746,0.0011873533,0.00075614423,-0.06572422,-0.06327079,0.07328703,0.03535697,0.00732791,0.046902314,0.023855295,-0.00012142352,-0.011568501,-0.019746449,0.02468864,-0.05503005,-0.060850207,-0.09910313,0.086195074,-0.05440555,-0.02556474,0.025878824,0.05494721,-0.021374712,-0.027819226,-0.011999852,0.027941076,0.0009687606,-0.012667641,-0.097852305,-0.0025921357,-0.06891736,0.013202023,-0.055959657,0.04754352,-0.0117514115,-0.040836327,-0.037683878,0.022750013,-0.06716436,0.0011512977,0.06619736,0.008074792,-0.051184073,0.007931731,0.007223238,-0.05456182,-0.031689215,-0.0593054,-0.13805784,0.039767213,0.053121127,-0.04936068,-0.043107364,-0.023888826,0.036892604,0.004554263,0.113189064,-0.034459926 +1.14.13.155,Involved in the catabolism of alpha-pinene.,384,1.0,0.043374144,-0.07420257,-0.047019128,0.08155876,-0.015356919,0.02638974,0.017686618,0.018147666,0.0007017904,0.042569846,-0.014354471,0.08400835,-0.070398614,0.088732585,-0.12045804,-0.005949027,-0.14469908,0.04960691,-0.0002759928,0.088583685,-0.008511687,0.031940714,-0.0063917846,0.082713135,0.02513091,-0.07824601,-0.015965786,-0.031495444,-0.0030919192,-0.014780557,0.07304459,-0.03783729,0.081640616,0.055924382,-0.08891673,0.020552844,-0.021661725,-0.085993454,0.059301827,0.10338817,-0.003371654,-0.02432162,-0.033228703,-0.00018671056,-0.022854768,0.012927463,-0.043963205,-0.020494008,0.015711239,0.055044368,-0.0066379,-0.13837197,-0.073645875,0.013102781,-0.029178945,-0.025115618,-0.0006506639,-0.09261115,-0.03060402,-0.00097053644,0.019411376,0.03169493,-0.043703545,0.024462035,0.023778077,-0.0032687578,-0.022892226,-0.01887624,0.021222802,0.001118052,0.03956901,-0.029244943,-0.061328664,0.006415091,-0.088720806,-0.019282628,-0.0047246516,0.021206673,0.0014491752,-0.056847673,0.032785326,0.03282045,-0.04092382,0.111581676,0.013215525,0.08702613,-0.026522556,0.032388937,-0.034462422,0.05858262,0.03947988,0.07475024,-0.03131569,-0.009903116,0.00411737,-0.0027025195,0.035495978,-0.008299412,-0.041651145,-0.038320728,-0.08005277,0.027627375,-0.017878728,-0.087690845,-0.10626715,0.00422049,-0.0070715994,-0.039271932,0.009724337,0.0005487764,0.013243668,-0.010368854,-0.036300108,0.06664222,0.03244293,0.12104278,0.07035301,-0.010105646,-0.040334642,-0.011714321,-0.07903693,0.024469906,0.048208456,0.07280366,-0.09374092,0.017355297,0.037713114,-3.4134674e-33,0.046441894,0.026776964,-0.036778357,0.0639551,-0.0042463774,0.021170076,-0.0780009,-0.08540445,0.044292808,-0.016485674,-0.085447796,-0.025006209,0.020125665,-0.02729951,0.010411039,0.0040844767,-0.046933923,-0.01436509,0.027799953,-0.0001324527,-0.052384004,0.06832584,-0.062422764,0.033228453,-0.0017554613,-0.0103852125,-0.02359334,-0.012086416,-0.012956775,-0.05286572,0.08981851,0.050584514,-0.10682636,0.07576382,0.007017898,-0.02764094,-0.030687304,-0.012401524,-0.0020374863,0.10269442,0.09748796,-0.019404538,0.03509401,0.048909966,0.06661968,-0.058118995,-0.017192712,0.096839525,0.045717858,0.02861725,0.06433993,0.08737055,0.045329284,-0.053202014,-0.070210025,-0.047310926,-0.04243607,0.012772791,0.0044106836,0.07923883,0.067662984,0.03134436,0.04604521,0.032117054,-0.04086722,0.037122946,-0.09752166,-0.034321535,-0.053655982,0.014105766,-0.026346702,-0.11803299,0.059457473,-0.053140987,0.011283386,0.04042031,-0.026121363,0.06816917,-0.034085166,0.015745318,-0.052257553,-0.013288983,-0.0091347955,0.02091359,-0.060691122,0.05647381,0.087104864,-0.0017894821,0.0543895,0.075680025,0.064425446,-0.032200653,-0.10601718,-0.026384544,0.046507295,1.47218325e-33,0.014208309,-0.15036066,-0.023025945,0.0025054466,-0.049189843,0.043736514,-0.036915008,-0.041638482,0.0057827686,-0.0082377745,0.0505789,0.05445761,-0.019958664,-0.025980778,0.059767302,-0.007843795,0.0043079956,0.08383903,-0.021639626,-0.005503936,0.010607139,0.069140874,-0.06210192,0.019136282,0.038623597,0.03406772,0.05188585,0.013329723,0.059125673,-0.056955528,0.1369925,-0.013000437,-0.017997451,-0.032732073,-0.0190816,0.09013044,0.0548065,-0.021847114,-0.044826534,-0.055065364,-0.03084762,-0.042036552,0.02770981,0.0701351,0.08580671,0.008811817,-0.029505683,-0.06477774,-0.08016786,0.08535752,0.053374387,-0.012050254,0.041775554,0.01824888,-0.006033719,-0.010294744,-0.061961908,-0.028015027,0.00610517,-0.04298846,0.045995466,0.018102722,-0.0116824135,-0.04357539,-0.0072020823,-0.062045574,-0.011549256,0.06120812,0.032957874,-0.018149117,0.032108713,0.029028142,-0.022446578,0.052906282,-0.019527627,0.049423084,0.019617818,-0.09595447,-0.05178053,-0.051300034,-0.10227454,0.052822527,-0.039773375,-0.0054204646,-0.005012392,-0.009791615,-0.009920713,0.1209598,-0.012258932,-0.05884114,0.014420106,-0.051111374,-0.06502373,0.014439887,0.10137044,-1.7656344e-08,0.025258357,0.022020169,-0.02526079,0.016733382,-0.008106291,-0.07215769,0.04730864,0.049304094,-0.058205,-0.056848682,-0.062162157,0.08793049,0.09225863,0.036430407,0.014514063,-0.01335065,-0.0044453945,-0.025595853,-0.013602922,-0.0034534507,-0.03747137,-0.052418858,-0.047048658,0.00063728145,-0.06069429,-0.08940573,0.050855048,0.10170775,-0.07502103,-0.06375866,0.124015555,0.011668722,0.017942509,-0.019961154,0.010710831,0.052364726,0.06997473,0.0036015909,0.0415748,-0.0013493913,-0.034313727,-0.062023792,0.002966608,0.027516063,-0.047290258,-0.044127885,-0.053544804,-0.04221809,0.07716812,0.021452961,0.051569346,0.06725162,-0.013324007,0.02723426,-0.05773484,-0.02949109,0.008220428,-0.016931936,0.041744668,-0.021757456,-0.007864375,-0.05823075,0.09534003,-0.035354093 +1.14.13.156,"A heme-thiolate protein (P-450) which uses a flavodoxin-like redox partner to reduce the heme iron. Isolated from the bacterium Citrobacter braakii, which can use 1,8-cineole as the sole source of carbon.",384,1.0,-0.07129161,0.0547978,-0.07613599,0.05622666,0.105087824,0.08066334,0.030823408,0.09311508,0.0117127765,-0.008982066,-0.042907327,-0.05738037,-0.09122357,0.0046414235,-0.016314672,-0.004575766,-0.021357913,0.05028687,-0.019391092,-0.04032342,-0.027489347,0.06240493,-0.0024274394,0.050494906,-0.03425367,-0.006182338,0.054991268,0.028005188,-0.008355936,-0.05293398,0.029203214,-0.03670721,0.059056584,-0.007234422,0.010699026,0.083684154,-0.057891373,-0.095258154,0.03644735,-0.02377409,0.05574918,-0.036102585,0.014509563,-0.0016250547,0.011521903,0.018057516,0.0029217645,0.061300933,0.033190858,-0.04124561,-0.048908465,0.006304439,-0.08795503,0.041502886,-0.020929236,-0.03868108,0.03184454,-0.038401283,0.052281383,-0.03161871,0.03861421,-0.020145603,-0.018811746,0.0067308927,-0.017049279,-0.05934238,0.036514957,0.002906076,-0.010204243,-0.028676074,0.017702473,-0.0043933378,-0.081662945,0.05445487,-0.077051,0.11505411,0.008974698,-0.029666366,0.035758857,0.058362417,0.014279213,0.05182967,0.022524511,0.10804879,0.014541147,0.027554555,-0.07177718,-0.017102018,-0.07073829,-0.017968608,-0.011153334,0.086040266,0.038521394,-0.025819305,-0.08199189,0.030030422,0.05727748,0.020450912,0.027339011,0.022937477,-0.0057314066,0.032247487,-0.02891602,-0.11103484,-0.08872424,-0.013889364,0.01066057,0.038586598,0.14339522,-0.019122528,-0.04494922,-0.02452996,-0.028396351,-0.069803394,0.022450073,0.08117223,0.089482605,-0.022790942,-0.014582614,-0.0032063902,-0.029892087,-0.019738719,0.03961259,-0.0065044053,-0.08509642,-0.028135354,-0.08046667,1.738272e-33,0.085122995,0.029405579,0.035711665,0.035198286,0.042126387,0.0060020452,-0.1342567,-0.005151696,-0.03269162,-0.006720047,-0.10543923,-0.06623807,0.033722732,-0.034580864,0.0025281892,-0.091022536,-0.07273657,-0.025982058,0.047358952,-0.028865654,-0.040096052,0.021183519,0.026300387,0.05608215,0.052858982,0.06048363,0.024380414,-0.009096003,0.022415414,-0.012580535,-0.0016419368,0.021323524,-0.070983954,-0.07354782,0.025867084,-0.041720547,-0.0798728,0.01367364,-0.08830078,0.053077597,0.04174952,0.039583992,0.0064076814,-0.07728682,0.08610591,-0.08055381,-0.10016341,0.048622787,0.01891844,0.04885034,0.02609389,0.01611022,0.060716797,0.037345883,-0.07789669,-0.009450404,0.033616178,0.03711866,0.059626296,0.04292463,0.12999405,0.06149742,-0.00480442,0.050075103,0.030080305,0.096533954,-0.032811224,-0.010898331,0.030878235,0.026941491,-0.0240264,0.02285933,0.027033689,-0.077309676,0.013410363,-0.06625818,-0.10265756,0.030195607,0.064220294,0.005534168,-0.009125097,-0.05074313,0.01964276,-0.017499981,-0.06424655,-0.014482698,0.0016325524,0.056182448,0.038252182,-0.032969378,0.05161246,-0.13540821,-0.026851635,-0.050319277,-0.034251794,-8.744044e-34,0.076086104,-0.07050369,0.015262693,-0.033228334,0.0028263798,0.008872183,0.009494954,-0.09181476,-0.038545314,0.020455778,0.14772534,-0.05358898,0.061910745,-0.008361765,0.042158518,0.06264996,-0.05766111,-0.018248154,-0.021517646,0.04733578,-0.022593519,-0.0318631,0.016195068,-0.01384005,0.03747159,0.023392584,-0.07290868,-0.03172855,0.123558275,-0.012739507,-0.07438228,0.039461724,-0.065513685,-0.10321801,-0.08624806,0.00089986564,-0.012086155,0.07008062,0.037687518,0.0082889525,0.016613718,0.011835632,0.019715087,0.089111365,0.016875386,0.11214163,-0.083030164,-0.06153348,-0.034000237,0.042162143,0.06377993,0.01707632,-0.07183138,0.020394402,0.0062064156,-0.051114354,-0.0038758647,0.07653003,-0.057631362,-0.019555409,-0.044260923,-0.051811576,0.026857425,0.036809612,0.067852154,0.10795984,-0.051063523,0.107490726,0.018970812,-0.021711864,0.07311291,0.046595577,0.10035487,0.0065701404,0.0068005463,-0.025242284,0.014365883,0.009234715,0.020968664,0.06681867,-0.02090133,-0.038960777,-0.06087225,-0.035040088,0.02195143,-0.05873595,-0.012426618,0.021250248,-0.011599819,0.035639506,-0.07205928,0.03365893,-0.00088406086,0.049073983,0.036387637,-3.333011e-08,-0.05275137,-0.089054205,0.0030774805,0.015874015,0.019268718,0.007059323,0.045867942,0.026710326,0.025363265,-0.013254003,-0.015645953,0.070245475,0.027233744,-0.043394227,0.026087092,0.00485383,-0.02262486,0.023218857,0.049320552,-0.010638379,-0.02814428,0.034228344,0.00044760064,0.02632473,0.028699143,-0.097924925,-0.014571965,-0.06284051,0.048788365,-0.015623481,-0.01459762,0.09713539,-0.028283838,-0.021113284,-0.02649466,0.026870428,-0.044351265,-0.010157896,-0.06129018,0.022028048,-0.035750978,-0.0058576544,-0.12932466,-0.050129715,-0.014525433,0.0038696458,0.007675198,0.06525721,-0.0458424,-0.038222715,0.029693702,0.02641335,0.023275131,-0.028262557,-0.0861378,0.04583646,0.067177385,-0.041386217,-0.028150942,-0.043964025,-0.007250696,-0.072421916,0.15443578,0.012211785 +1.14.13.157,"A heme-thiolate protein (P-450). The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.13.97 (taurochenodeoxycholate 6-hydroxylase), EC 1.14.13.67 (quinine 3-monooxygenase) and EC 1.14.13.32 (albendazole monooxygenase).",384,1.0,-0.035422005,0.001662219,-0.022893354,-0.010385325,0.07266919,-0.0020385555,-0.035074443,0.11221155,0.0036590258,0.004742499,-0.03829431,-0.019581871,-0.09845868,0.037420493,-0.01775146,0.03223634,-0.07984918,-0.020507192,0.039919063,-0.07976816,-0.026713887,0.061163675,0.0099304,0.00561542,0.018191041,0.012081293,0.080468886,0.034562152,-0.04719121,-0.046521507,-0.01469129,-0.027781274,0.07316829,-0.03008932,-0.04397778,0.1098631,-0.07107433,-0.049947266,-0.027901623,-0.01710569,0.07806445,-0.03597058,-0.07463177,0.024090538,-0.044210833,-0.0481608,-0.013991284,0.015773136,-0.0017465123,0.07697903,-0.019645128,-0.040038902,-0.087095894,0.05994424,-0.0041163866,0.005501461,0.012683181,-0.042666733,-0.024300972,-0.038011625,-0.049973067,0.0033329362,-0.00054928067,0.03371059,0.02271501,-0.04242476,0.057586897,-0.051168047,-0.041534826,-0.07706372,-0.019507112,-0.08544177,-0.019376867,0.006224136,-0.079454504,0.04548228,-0.052987084,-0.04697505,0.010062113,-0.010523134,0.00040682088,0.017401483,0.03353184,0.0927252,0.06541121,-0.057533253,-0.048944484,0.008108533,-0.063493825,-0.0197045,0.012342909,0.048525713,0.015055765,-0.03375413,-0.040835664,0.071313664,0.029835194,0.040725686,-0.013182044,-0.018383767,0.019171333,0.054747306,-0.088824406,-0.056658674,-0.031401668,0.036791876,-0.01738823,0.09780653,0.047312353,-0.05352769,-0.01991996,-0.037492927,0.05641868,-0.0073910533,0.052096073,0.10207552,0.04976145,-0.0199531,-0.022603346,-0.016430525,-0.07692502,0.017634135,0.08641498,0.009862801,-0.03166506,0.004137806,-0.027850075,1.3351999e-33,0.090937294,0.030914973,-0.030056534,0.0067873504,0.02190606,0.00010613106,-0.05762369,0.068644375,-0.012266315,-0.028889792,-0.04490965,-0.03727095,0.04739284,-0.011204961,-0.0068840105,-0.027077742,-0.0047381534,0.040039014,0.09925138,-0.00071728154,-0.086676024,-0.02359854,-0.026477458,0.041189674,0.020591956,0.07075518,-0.022240316,0.0025630596,-0.01211421,-0.0060836393,-0.08857156,-0.00081572577,-0.050573215,-0.0382279,-0.04740249,0.01461764,-0.04321818,-0.00057617266,-0.09271614,0.05699431,-0.00042310078,-0.010321467,0.02180027,-0.11420137,0.045268375,-0.047840793,-0.103734545,0.050809484,0.008491572,0.03505179,0.053541787,-0.041020248,0.12917611,0.0061659417,-0.062638484,0.025330843,-0.016597109,0.0350794,0.044247855,0.08126471,0.11508462,0.07720768,-0.04334557,0.070611864,-0.011200601,0.038125977,-0.07796709,-0.03397579,-0.06351355,0.14020108,-0.009781307,0.03835469,0.07964508,-0.041602403,0.012098199,-0.0074815745,-0.04144455,0.06342535,-0.009185261,0.00878903,0.025864286,-0.021263696,-0.015789548,-0.024246214,-0.021041024,0.0068686614,0.044610195,-0.009706882,0.008051801,0.009723421,0.05557912,-0.094406895,-0.041402034,-0.045238763,0.006393934,-1.3193226e-33,0.07840393,-0.0923831,-0.0026660725,-0.073191985,-0.017090648,0.07016403,0.022277907,0.024629693,0.005909654,-0.013986086,0.1166286,-0.04525003,-0.03311152,-0.07677672,0.06315215,-0.005372463,-0.030640483,0.026128506,0.01820868,-0.025429675,-0.00013345519,0.044464286,-0.016462065,0.042948212,0.060784694,0.023413116,-0.03786261,-0.017709114,0.08843285,0.036837902,-0.09067376,0.06546132,-0.028538432,0.014918509,0.015467755,0.046016723,-0.04024794,0.018671744,0.012958571,0.020862676,-0.0010192604,0.058468174,0.007870217,0.13858885,0.029660234,0.09312463,-0.10247045,-0.05803696,0.000951332,-0.058595408,0.029097138,0.025111236,-0.019657379,0.01979162,-0.016650135,0.019180348,-0.0023390527,0.0013961114,0.04364887,-0.08977907,-0.03798154,0.0043565147,0.014554393,0.0397571,-0.0016604783,0.052047867,-0.120705314,0.018006781,0.0028794138,0.022048425,0.07264191,-0.019871831,0.027943525,0.0659001,-0.00535397,-0.012650884,0.027561756,0.017135723,0.03065381,0.022778729,0.02750009,0.021672035,-0.023487216,-0.028659757,-0.053924315,-0.09090965,-0.044291858,0.15034577,0.00042142434,0.019462127,-0.026191022,0.037437845,-0.0858916,0.051735416,0.057396356,-4.8145832e-08,-0.008513043,-0.09166156,0.026588894,0.030307423,-0.0008328823,0.07459419,0.08156556,0.0070565287,0.065167375,-0.015497915,-0.0043765195,0.08641599,-0.017314332,0.01370923,0.031880073,0.053730246,-0.029444726,0.013167105,0.0038329952,0.013376675,-0.06687027,0.02092141,-0.014548773,0.049498618,0.005522574,-0.08398432,-0.026019491,-0.008522554,0.003558468,-0.033426557,-0.03537735,0.043361317,-0.042558607,0.028812625,0.029870056,0.036218088,0.021922836,-0.047039263,-0.01685561,-0.009788427,-0.058358252,-0.072390586,-0.11709505,-0.0477496,0.06794739,-0.01119664,0.030376881,0.040607188,-0.023211874,-0.03019015,-0.03747853,0.015677273,-0.008900507,-0.049229547,-0.09346615,0.018512486,0.0283661,-0.09267697,-0.04241028,-0.14197727,0.07188971,0.01363969,0.26183167,-0.05262078 +1.14.13.158,A heme-thiolate protein (P-450). Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin.,384,1.0,-0.10505232,0.00472896,-0.011089072,-0.03932554,0.09152846,0.054407448,0.0056206807,0.036308993,0.03776718,0.036250878,0.040664617,0.0031896955,-0.12070109,-0.052868422,-0.062539406,0.038230844,-0.07448015,0.0577634,-0.055384807,-0.07166036,0.032617148,0.10466595,0.017694084,0.029475195,0.01253117,0.017392462,0.007365656,0.05249242,0.014599237,-0.06683231,-0.007880832,-0.015626734,0.0137327155,0.0061116396,-0.06698862,0.1584702,-0.045106795,-0.10603213,0.06994993,-0.06865772,0.13248767,-0.09344017,-0.06944619,-0.040422305,-0.062542796,0.0128252655,-0.022562377,0.04152019,0.06669604,0.039283354,-0.03589657,-0.07295194,-0.048310854,0.018266212,-0.047112487,0.008036948,0.044527195,0.035695214,0.01753106,-0.0065754545,0.027665999,0.084993124,0.008567649,0.042343043,-0.029346423,-0.018313697,-0.024412943,-0.02607383,-0.0043501747,-0.07060766,0.023399187,-0.045748286,-0.01597213,0.061577637,-0.028518928,0.07054691,-0.035520043,0.009080038,-0.005380956,0.013500322,-0.0023521383,0.062839486,0.050416514,0.16717051,-0.058213573,0.0012324332,-0.0035039864,0.084152564,-0.008848278,-0.09175052,0.018498292,-0.01205072,0.020544343,0.013556366,-0.059677925,0.11303577,0.0011461165,-0.04510349,0.0276381,-0.013575209,-0.025325328,0.023682002,-0.049951337,-0.10279445,-0.1025045,0.036605854,-0.06702708,-0.004805984,0.072604276,-0.026472101,-0.032082934,-0.010691112,0.049114425,-0.0065924567,-0.050523113,0.031797603,-0.0646156,-0.0015619699,0.025025547,-0.053504627,-0.05114851,-0.022592548,0.056166794,0.029429182,-0.04713858,-0.032646514,-0.079429545,2.2929225e-34,0.1110231,0.018956944,0.049636412,0.024345165,0.008424362,-0.05454175,-0.028862683,0.042768378,-0.02790599,-0.04625107,-0.09817623,-0.14405382,-0.0025531338,-0.04916579,-0.020255357,-0.013476221,-0.018438758,-0.0061643436,0.06618811,0.0489478,-0.06214065,0.05743619,-0.03397514,0.006031572,0.020708065,0.061031528,0.01856119,-0.02049742,0.048636712,-0.0088643115,-0.01194726,-0.053829867,0.009428301,-0.039178476,0.03923523,0.004244463,-0.022659415,-0.019816713,-0.07120884,0.049858727,0.0049725007,0.055779696,0.064931564,-0.067157105,0.03619534,-0.024732228,-0.09956536,0.06797359,0.040923588,0.035864502,0.031367417,0.027896864,0.1376985,0.03454304,-0.05490027,-4.3828382e-05,0.0027582825,0.028140137,0.03711961,0.018660454,0.092712216,-0.017639678,-0.0173892,0.02038607,0.04904063,0.092366025,-0.043692492,0.011091379,-0.0061032264,0.05082532,-0.051705442,-0.013222568,-0.051504478,0.018475043,0.036252204,-0.018717935,0.02176802,-0.02523756,0.00052978867,-0.0027932825,-0.026364425,-0.017094877,-0.024844117,0.010628651,-0.022758987,-0.043797743,0.0059039397,0.044881992,-0.00429714,-0.033834744,0.07702962,-0.07989546,-0.06313744,0.023258513,-0.048587818,-8.038311e-34,0.031717222,-0.109993115,0.027249863,0.015817124,-0.035625007,0.027638486,-0.00633109,0.039891597,-0.017015798,0.0961479,0.13368586,-0.038881507,-0.0010582632,-0.017735245,-0.015949778,-0.0048755435,-0.005065399,0.036905065,-0.010335926,0.070503265,-0.016378533,0.074247874,0.0010220065,-0.010880654,-0.004113139,0.024677185,-0.004938521,0.07345882,-0.019785678,0.032982826,0.035503402,-0.02331726,-0.11169987,-0.05779868,-0.02080767,0.023072477,0.056775805,-0.057642017,0.04499529,0.009163634,0.04389329,-0.009380764,0.029780462,0.04857488,0.03741318,0.0496204,-0.093511276,0.011661666,-0.062079385,0.01760655,0.025684604,0.0374225,0.036793895,0.054625604,-0.01834685,-0.03956136,-0.0046647284,0.06796515,0.0046106754,-0.077961236,-0.019661391,-0.047080345,-0.0027465615,0.09346392,-0.0069974335,0.092471614,-0.11374921,0.047402114,-0.02874819,-0.01779437,0.0077472404,0.010289588,0.052721802,0.07815334,0.025309999,-0.04856527,0.0056894924,-0.08028894,0.031063901,0.032415047,-0.009287848,0.011917751,-0.051882807,-0.08654573,0.022455687,0.002580788,0.0108149145,0.095621884,-0.042481072,-0.013633381,-0.0066185105,0.039906528,-0.08655872,0.052718908,0.0696349,-2.7069172e-08,-0.035700765,-0.046284754,0.03403418,-0.035520732,-0.016690338,-0.009832003,0.021837953,0.06626486,0.019067,-0.022153096,-0.0036907657,0.0602322,-0.04050314,-0.005424969,0.02390752,-0.025149023,0.031401083,0.08348521,0.010850678,-0.038881402,-0.0041700453,0.0011271276,-0.0050589205,-0.02508872,0.028679894,-0.116690084,0.043887597,-0.0355513,0.008207396,-0.058659475,-0.0016429789,0.06405386,0.010982016,-0.05011345,-0.0063532684,0.06877972,-0.06746045,-0.025309427,-0.012162473,-0.057341553,0.0118914675,-0.021041153,-0.08035789,-0.07056899,0.058724456,-0.020312991,0.07210304,0.09298077,-0.042618286,-0.023886483,-0.0068918355,-0.017111916,0.06993103,-0.10123107,-0.12226533,-0.09206517,0.047745544,0.00093358883,0.0023363277,-0.072562784,-0.014259225,-0.028510788,0.16318141,-0.023914803 +1.14.13.159,"A microsomal enzyme isolated from human and mouse liver which bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4].",384,0.99999994,-0.106341526,-0.034441967,-0.064440034,-0.08153771,0.012750161,-0.0011383337,-0.019559266,0.025988352,-0.023344764,0.07040042,0.012762874,0.0030199531,-0.0540066,0.022811923,0.014689455,0.0023264466,-0.018241609,0.13283718,0.017791951,-0.050744336,0.009862664,0.018367995,-0.0037572093,-0.013062723,0.07840554,0.045575347,0.1016885,0.02081522,0.02222956,0.03624184,-0.0016061986,-0.03742946,0.077925175,-0.098157056,0.033456463,0.028771209,-0.051123295,0.02240511,-0.09256269,0.023603717,0.011636966,0.026698502,-0.027082345,-0.037823785,0.0067177056,-0.025679687,-0.052778654,-0.014547909,-0.013770486,-0.040976778,-0.062571354,-0.022406396,-0.00015561098,-0.011974147,0.028221408,-0.0035128903,-0.04956951,-0.005007917,-0.012620971,-0.013258269,0.008493963,-0.052066457,0.05269476,-0.024315553,0.13971782,-0.013501005,-0.011107658,-0.049532894,-0.0051870784,-0.098242916,-0.07807225,-0.10478011,-0.0426911,-0.0029132592,-0.042155042,0.0013062719,-0.010636557,-0.036264688,0.029052908,0.020604208,0.008550827,-0.014423887,0.029214611,0.109379426,0.00042737898,0.04135226,-0.038877998,0.054932203,-0.014774293,0.07469465,-0.05397037,0.0570308,-0.015052189,0.009374148,-0.07899689,0.06540853,0.02214727,0.043241963,0.07778126,-0.026113454,0.02600418,0.11550475,-0.03774866,-0.091567814,-0.043054584,0.010435591,-0.04040671,0.058005203,0.0037232633,0.039911963,-0.02300322,-0.010850033,-0.07854204,0.02949695,0.0064296764,0.08783577,0.088869095,-0.058076564,-0.026782854,0.01767268,0.027208664,0.0176469,0.075787365,0.016142907,-9.3079056e-05,-0.008430023,0.01335356,3.7001895e-33,-0.008811094,0.052386295,-0.013378496,0.09988623,-0.031130247,0.028150227,-0.009559333,0.043620177,-0.012668156,-0.074548855,-0.08024097,-0.10224031,0.05155934,0.028950134,-0.03594877,-0.010496953,0.034255877,-0.0414588,0.08507261,-0.031098967,0.061244737,-0.019469779,-0.0038043594,0.0058673914,0.035178967,0.025594387,-0.022959337,0.08863181,0.08711871,-0.032572214,-0.047924448,-0.12995541,-0.04254709,-0.018484406,-0.006145502,-0.013491335,-0.045334514,-0.05101309,-0.025821364,0.14317049,-0.04317213,-0.070930116,0.032799516,-0.05626633,0.03712133,0.023098867,-0.09981016,0.059489172,-0.04207159,-0.005550947,0.114530444,0.053168487,0.06664289,-0.051358383,-0.06269747,0.0028463418,-0.06633334,-0.05463759,-0.027718524,0.049554043,-0.051540103,0.02780192,-0.017791113,0.1153504,0.01193609,-0.0073180743,-0.083272904,-0.013477903,-0.12969676,0.08304407,-0.0019775042,-0.035503637,0.09981815,-0.028484385,0.05606321,-0.035144407,-0.018948352,0.023971265,0.029298954,-0.04072165,-0.081878945,-0.002955038,-0.045250606,0.008495038,0.010571712,-0.034534167,-0.035442933,-0.10605381,0.025417475,0.018981192,-0.004784669,-0.10227973,-0.04963511,0.031399764,0.032310277,-7.110849e-33,0.008608467,-0.023939896,0.026155274,-0.07741842,-0.004061377,0.065461256,-0.0026638357,-0.017027583,0.07267841,0.0015583014,-0.011059817,-0.05707017,0.04295399,-0.04310064,-0.041471895,0.0047687227,0.019189227,0.08797712,-0.016795816,-0.0065713106,0.043797694,0.0059226197,-0.011653986,0.04659113,-0.029414313,0.014082611,0.04078093,0.0086293155,0.004396451,0.12641847,0.008458645,0.026943462,-0.034021925,0.0056366744,0.018518304,0.079101734,-0.04742013,-0.05433154,0.0025336063,0.019924834,-0.061983313,0.03370919,-0.022135422,0.07917423,0.0052526495,0.028668571,0.014462852,0.0046673045,-0.041209582,-0.012130495,0.043519594,0.043679975,-0.027425703,0.03154749,0.00519976,0.10098001,0.07540894,0.009165094,0.08166192,0.0029624982,-0.01903741,-0.09167487,0.018889258,0.032485243,0.019712767,0.033638418,0.018765885,0.13053274,-0.06856565,-0.00058738387,0.10057025,-0.025303062,-0.01700251,0.024389477,-0.016603556,-0.033296995,-0.025058784,0.030310605,0.012476386,-0.03152725,0.062650986,-0.059584476,0.018145982,0.010398048,-0.058388345,-0.15816645,0.005473992,0.11988688,-0.08537324,-0.03356846,-0.03492788,0.039716873,-0.08838368,0.05446722,0.08657734,-4.3616414e-08,0.088302076,-0.028322795,-0.014120973,-0.041401938,-0.0315885,0.034049083,-0.052677684,0.024432031,0.032513868,0.0066920826,-0.043394934,0.05870771,-0.014721306,0.0007338668,0.07632732,0.059130244,-0.06286478,0.02347443,-0.034002192,-0.012387198,-0.074669056,0.05719066,-0.09165518,-0.034273647,-0.020829268,-0.06988351,-0.03387712,0.07295174,0.015461778,-0.019722186,0.037783753,0.016102046,-0.018162962,-0.0074547436,-0.029892026,-0.0520438,0.031904444,-0.062668726,-0.0025093663,-0.019988373,-0.07123263,-0.09566234,-0.081121534,0.013092785,-0.08092579,-0.03531412,-0.059558257,-0.0012886429,-0.056213263,0.0375334,-0.053829525,-0.003936668,0.03340387,-0.06787625,-0.011642301,0.036839396,-0.01917239,-0.054811843,-0.059122507,-0.09794125,0.0100728525,0.040147725,0.089907475,0.0020460417 +1.14.13.160,A FAD dependent enzyme isolated from Pseudomonas putida. Forms part of the catabolism pathway of camphor. It acts on the CoA ester in preference to the free acid.,384,0.99999994,-0.05364684,-0.024478834,-0.09852111,-0.01913153,0.088967316,0.0960175,-0.094767444,0.06041109,0.034179084,-0.0140516525,0.080797344,-0.05496554,-0.07289866,0.050503254,-0.013035126,0.011692657,-0.081667356,-0.0010907006,-0.028609132,0.0017425488,0.020779595,0.0852942,-0.034862112,0.029478077,0.040404227,-0.0061077857,0.08130524,-0.048042264,0.013050517,0.010583953,-0.0561202,-0.038919624,0.016047932,-0.040127836,0.025676453,0.020058468,0.074307874,-0.0113410335,0.04296919,0.008178563,0.015577373,-0.06520139,0.00099575,-0.11312139,-0.0068048467,0.00038013284,0.05797977,0.020291869,-0.0025053795,-0.05598294,-0.06870339,-0.058086388,-0.008767077,0.020001816,-0.010978155,0.027840799,0.033754174,-0.035588138,-0.050582927,0.014319532,0.011111574,0.008133009,-0.014944575,0.011767342,0.0059092357,-0.055748094,-0.009328472,0.020667074,0.01590829,-0.029947542,-0.0021785933,-0.083078675,0.046581294,-0.034370437,-0.02174088,-0.03145868,-0.0022383516,-0.018112572,0.09608769,-0.042155396,0.032593615,0.040351477,0.04002404,0.07262226,-0.04622041,-0.033724062,0.07413307,0.017943582,0.05026879,0.025705816,-0.012243302,-0.059149325,-0.0794132,-0.08145896,-0.059125718,0.05399376,0.061054528,0.008239485,0.030867144,-0.016839564,-8.901802e-05,0.039992165,0.004512815,-0.06474986,-0.11167715,-0.029072907,0.044755273,0.08106347,0.038095195,-0.004922379,0.012146495,0.035311345,-0.022130303,0.0071146577,-0.046716776,0.023515318,0.037279826,-0.15220757,-0.05210069,0.006704998,-0.014897619,-0.03508835,0.06352717,0.15523541,0.026984844,-0.0078138085,-0.10266714,2.2445991e-34,0.07814646,-0.001028708,-0.009069385,-0.0415981,0.06933675,-0.004464364,-0.121366754,-0.014291751,-0.028335089,0.0181225,-0.06602231,-0.089836374,-0.05294129,0.03205352,0.04076964,-0.036063965,-0.05785397,-0.03274226,0.08954014,-0.08895423,0.0054760873,0.10019216,-0.022809999,-0.03279863,0.069113225,0.013504734,-0.0032022118,-0.036352187,0.020959742,0.0138648935,0.087846,-0.05545432,-0.10921375,-0.010220055,-0.0020589363,-0.011916197,-0.1002242,-0.0036099984,-0.060307547,0.06284155,0.1320701,0.04503642,-0.004459295,0.0011842588,0.08115183,-0.10837665,-0.036677677,0.14002594,0.08531522,0.089218326,-0.0116799055,-0.013452628,0.050270077,0.035898417,-0.074368864,-0.012527647,-0.119676314,0.011038134,0.0147731565,0.038676508,0.03139397,0.05254311,-0.03811871,0.097348765,-0.0073967497,-0.035619225,-0.0693839,-0.023008563,0.06605974,0.038690004,-0.066239975,0.015065791,0.012931232,0.04624191,0.008389391,-0.11524828,0.0069195703,0.034615155,-0.006355939,0.0090046935,-0.0019355475,-0.05071372,0.015193283,-0.016074698,-0.10247581,0.05226753,-0.0056418274,-0.02997636,-0.05055278,0.02077597,0.05602278,-0.056941938,-0.05064268,0.031450037,0.087066635,-1.1860677e-33,0.047072798,-0.12578785,0.08748165,-0.1067966,-0.011051327,0.022217736,-0.02723155,0.025936462,0.05026013,-0.0066675837,-0.02264031,0.009146282,0.08237605,-0.022174072,0.059417136,0.041628387,-0.024582047,-0.0057789325,0.033041,0.031498235,-0.026682725,0.057456657,-0.02891892,0.034656413,0.06561447,0.03957638,-0.029462395,0.10967769,-0.019099636,0.066133335,0.04696316,0.047027122,-0.078915425,-0.015603074,-0.02891453,-0.003973608,-0.048877113,0.046831857,0.005028018,0.03783988,0.019460125,0.02986727,-0.0261613,0.03756716,0.0061927917,0.053880602,-0.090468876,-0.0143578155,0.024005206,-0.11434541,-0.00012141809,-0.042036884,0.002537027,-0.033357993,0.09210716,-0.006930081,-0.04294359,0.029285796,-0.088468544,-0.034085132,0.031899385,-0.04768638,-0.021401428,-0.02119885,0.109073825,-0.021616034,-0.0129322605,0.023905573,-0.01290851,0.03253678,0.076600134,-0.0056809084,-0.049060583,0.03665838,-0.027329924,-0.027702557,-0.054397214,-0.027852189,0.023424558,-0.004468771,0.034791667,-0.037503626,-0.04197725,-0.07619504,-0.010342445,-0.0081970785,0.038914155,0.1412171,-0.023372503,0.017630097,-0.0027186938,0.01753906,0.0022571317,0.043609437,0.04465709,-2.9140772e-08,0.068410374,-0.115717076,0.050465263,0.025717694,-0.054641366,0.018207844,0.020740736,-0.021888848,-0.006426173,-0.047328822,-0.067822486,0.053068615,0.035131246,-0.013056506,0.049945295,-0.01192941,-0.06294129,0.011680435,-0.05779765,-0.020167273,-0.08829654,0.0033390871,-0.05750099,0.023931244,-0.0041415314,-0.005826485,0.07452577,0.06336656,0.014938267,-0.02320055,0.045287553,0.005575669,-0.008460356,0.0071670935,-0.04881794,0.090349704,0.024874335,-0.0229632,-0.062536545,0.05040012,0.0720966,-0.051165983,-0.0070521743,-0.03400903,-0.0064903963,0.0317892,-0.005334979,-0.038233478,-0.0053995303,-0.031028468,0.045968503,0.04235617,0.02465063,0.030309075,-0.06764984,0.0044534,0.00019452136,-0.050580624,-0.01718611,-0.000963118,0.0253606,0.06688147,0.11317254,0.02744349 +1.14.13.161,A cytochrome P-450 monooxygenase isolated from Salvia officinalis (sage). Involved in the catabolism of camphor in senescent tissue. ,384,1.0,0.006399275,0.039475955,-0.07647336,0.02258524,0.095420815,0.10002644,-0.05484301,0.016582359,0.0007844175,0.011752337,0.018925387,0.0020070812,-0.00928825,-0.011206842,0.0013979452,0.047548447,-0.0068865134,0.0008510185,-0.01680013,-0.012548375,0.049120843,0.0037898899,0.06340846,-0.014796284,0.052022643,-0.01741334,0.030507436,0.045244448,-0.10709567,-0.049006656,0.043357518,-0.019694012,0.048999302,-0.07311586,-0.005421013,0.06841274,-0.029123394,-0.031260353,0.08290966,0.055961188,0.012700848,-0.05379625,-0.1206563,0.00699808,0.010021912,-0.1092955,-0.00661181,0.0067671095,0.09449547,-0.07788024,-0.07678892,-0.075624935,-0.0031069578,0.027540587,-0.00079291925,-0.020738766,-0.005273555,-0.07246889,-0.06254906,-0.03776936,-0.052345376,0.032738715,-0.012695011,-0.0504461,-0.048005395,-0.059243694,0.038627673,-0.08932673,0.022832925,-0.08425632,-0.061114296,-0.098248586,0.0075317947,-0.019088743,-0.10841672,0.0037404348,-0.0070677157,0.009002948,0.01102906,0.0027462475,0.029931083,0.06468217,0.037859406,0.022502642,0.047540486,0.035077307,0.070170924,0.041124176,-0.024799211,-0.004450131,-0.021340206,-0.025135713,-0.0063060545,0.0018871905,-0.05608929,-0.020691698,0.054866247,0.04202816,-0.012167428,-0.0073815817,0.06705286,0.021751875,-0.058011062,-0.10885827,-0.055776272,0.057722483,-0.037466682,0.013510472,0.019671928,-0.13838443,-0.013305051,-0.012023584,-0.04906493,0.0068382975,0.01732031,0.1035036,0.014787942,-0.065334395,-0.09783427,0.03637476,0.017696816,-0.035811905,0.040780306,0.030087853,-0.025454316,0.09346137,-0.0008858085,1.4094366e-33,0.05172322,-0.0135505,-0.009894142,0.03867678,0.01882711,0.018548274,-0.08979605,0.08013631,-0.02360596,-0.048594777,-0.055270735,-0.058447458,-0.023333924,-0.008639301,0.008523273,-0.0040521026,0.009651546,-0.059393365,0.08973995,-0.0463334,-0.16512796,-3.5918332e-05,-0.021869408,-0.03923917,-0.053956226,0.09663482,0.008391444,-0.05530195,0.07328601,0.019447923,0.09059765,-0.050178483,-0.050324112,0.02559802,0.0075908,-0.025415096,-0.0074304882,-0.03902303,-0.046288136,0.030798633,-0.05000012,0.04572357,0.05299459,-0.025713699,0.016645188,-0.063718244,-0.089437015,0.049803644,0.12737115,0.032517176,-0.01167573,0.05944074,0.11654813,0.072122835,-0.06376455,0.012047342,-0.003348771,0.03623962,-0.023062496,0.07037911,-0.007399534,0.0027680767,0.005796394,0.016154153,0.04698942,0.03947854,-0.083420925,0.020857302,0.008907982,0.1156074,0.0072204373,0.055078868,0.018050125,0.047818307,-0.004920588,-0.013883058,0.054571748,0.12109835,0.040072873,0.03005277,0.03204923,0.05925661,0.011028309,0.02922859,-0.021206222,-0.0056009362,-0.011277909,-0.03955175,-0.020083783,0.06779946,0.031652603,0.01627034,-0.10991234,-0.0761614,0.0035152033,-1.2730379e-33,0.08970082,-0.04795657,-0.0813856,-0.053539447,-0.058579426,0.11919958,-0.011758115,0.015317683,-0.101835825,0.06275729,0.028255727,-0.040156778,0.041293252,-0.05362129,0.047989134,-0.02763836,-0.022492038,0.10255102,-0.026503786,0.056502163,-0.028405512,0.007685574,0.039556,-0.036010914,0.06963808,0.035576075,-0.047676373,0.00028793787,0.01765008,-0.00816633,0.046951957,0.067784175,-0.07962971,-0.052683227,0.018436737,-0.0008568871,-0.039205674,0.0099013755,0.007548626,0.10375209,-0.0194589,0.0337267,0.007953758,0.014042466,0.07715123,0.04817926,-0.1200957,-0.023175912,-0.05340384,-0.069795325,0.02485058,0.020093417,0.016861115,-0.021906795,0.037538975,-0.01529567,-0.06105655,-0.02232133,0.050972857,-0.07631278,0.03783946,0.047354296,-0.048494957,0.054526623,0.029807962,0.0150418,0.0321838,0.0070878146,-0.017037096,0.006264666,0.014859051,-0.04119456,0.021141445,0.053361584,-0.043510266,0.07818802,-0.014011826,-0.012468195,0.0472434,0.013599657,0.06051905,-0.032570735,-0.014423718,-0.07915253,-0.024412079,-0.06314643,-0.005880899,0.08663149,0.010415859,-0.057734847,0.05631848,0.038135864,-0.08107764,0.007084467,0.12111862,-2.5223978e-08,0.057471078,-0.105037935,0.023527863,0.012711537,-0.010599585,-0.028078532,0.007995902,-0.010203318,0.028320609,-0.011471848,0.01045944,0.04230367,0.03700711,0.010761106,0.00770358,0.022228425,0.08081788,0.04227217,0.040582474,0.053506605,-0.09931218,-0.003455175,-0.02134711,0.014074628,-0.0055842623,-0.13021256,0.038733035,0.081810124,0.071737975,-0.018418917,0.04344541,0.00600607,-0.022064587,-0.037542947,-0.02607103,0.029233206,-0.03246278,-0.039641812,0.026233308,0.015607719,-0.02469336,-0.08545835,-0.024401553,-0.026182847,0.020437077,-0.023768902,0.032724824,-0.008822403,-0.016967611,-0.048040662,-0.03430896,-0.0076344595,0.03789952,-0.039726093,-0.13499708,0.012722769,0.073803544,-0.064546235,-0.013150166,-0.114880756,0.023362188,0.08311528,0.059707526,0.010443921 +1.14.13.162,"A flavoprotein (FMN) which requires Fe2+. A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid. Involved in the degradation of (+)-camphor. Requires a dedicated NADH-FMN reductase [cf. EC 1.5.1.42, FMN reductase (NADH)] [1-3]. Can accept several bicyclic ketones including (+)- and (-)-camphor [6] and adamantanone [4]. The product spontaneously converts to [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate.",384,1.0,-0.075683,-0.03433208,-0.13539612,0.015950203,0.09446519,0.072483614,-0.09905495,0.027467148,0.019984948,-0.069440976,0.029825553,-0.057022247,-0.046529565,0.06140301,-0.058554307,0.075036876,-0.047383837,0.05059894,-0.010909873,0.04610752,-0.042245995,0.015255968,0.024230365,-0.01739705,0.032238413,0.012087993,0.037084848,-0.024606949,-0.10009871,-0.045360778,-0.014768413,-0.0137405675,0.07704297,-0.06660587,0.04412082,0.03892399,-0.0057794945,0.0051091765,0.057276964,-0.034481335,-0.024305804,-0.035644367,0.0014794231,-0.09270682,-0.032614883,-0.05816546,0.064774476,0.06120373,0.044683427,-0.026519787,-0.051852006,-0.015300759,-0.0388358,0.029945688,0.07064867,0.0040045986,-0.027963653,-0.055366553,-0.07128377,-0.01572023,0.032812543,-0.041714266,-0.010797355,-0.010996157,-0.068567924,-0.048565734,0.029208101,-0.022178415,0.022403637,-0.022798184,-0.009081111,-0.06419615,-0.014301487,-0.026923817,0.0048271525,0.07361596,0.040570293,-0.028627655,0.107635565,-0.02494893,0.03283013,0.007604516,0.051243752,0.05785697,0.037297785,-0.03722396,0.018295959,0.04901215,0.037013896,0.08710442,-0.033339217,-0.0043452373,-0.017862871,-0.02629399,-0.034054887,0.05700426,0.037901636,0.042517554,-0.027455308,0.0019195395,-0.025828267,-0.011275815,0.053434964,-0.04608402,-0.09643997,-0.02120473,0.008127165,0.12642646,0.014356496,-0.036854386,0.055840872,0.0110388445,0.03662426,-0.038095217,-0.06645173,0.1288883,-0.028097272,-0.11783181,-0.08842062,0.058996573,-0.0010389579,0.043784667,0.028778352,0.08631002,-0.0014849893,0.014325843,-0.082777,1.8665871e-33,0.050962448,0.060176697,0.01097663,-0.0012394715,0.057487123,0.015895069,-0.0864115,-0.033056844,0.004628334,-0.040903788,-0.037967492,-0.042630173,0.045020744,-0.011796654,0.02147495,-0.046196103,-0.05845071,-0.035445295,0.034571197,-0.011135927,0.025290204,0.027236838,-0.04524774,0.0074420725,0.038438335,-0.021111967,0.04331931,-0.027474096,0.06631894,0.023532748,0.006912566,-0.077548385,-0.08876408,-0.015058354,0.04840275,0.008948088,-0.08705042,-0.040504538,-0.101993434,0.07284389,0.03129449,0.10553583,-0.11918903,-0.021279795,0.059765693,-0.117804624,-0.059329,0.18922253,0.0163136,0.16465966,-0.014843834,-0.03781808,0.063327886,0.050745543,-0.06625804,0.04747203,-0.020909714,0.026815847,0.047550708,0.025394393,-0.027282385,0.041669488,0.049536224,0.015308754,0.017280607,-0.028284356,-0.07530141,0.016280167,-0.007942421,0.020085895,0.038819246,0.03473919,0.03742523,0.029268049,-0.0062295785,-0.078072,-0.03142521,-0.007198034,0.029537005,-0.0037704962,0.033253532,0.018751048,-0.005899385,-0.057524383,-0.093923494,0.03107443,-0.036466155,-0.048158176,-0.021588532,0.044898655,0.0780108,-0.055928618,-0.009258302,-0.043044034,0.0090198405,-1.5216983e-33,0.050834056,-0.06670191,0.02587132,-0.061032485,0.005045241,0.034178074,-0.012276465,-0.01933392,-0.008438231,-0.035222776,0.015763946,0.011517902,0.0510519,-0.03202247,0.018237196,-0.0044795945,-0.009007467,0.057288095,0.05581561,0.018162375,0.0036831133,0.0036442983,-0.06759324,0.08932532,0.037414033,0.049244493,-0.06322491,0.090282254,0.07799222,0.06590365,0.01876412,0.040916517,-0.070536256,0.004321543,0.10465554,0.08833462,-0.030921875,0.0385454,0.05036536,0.086453475,-0.015171846,0.0058519323,-0.064190686,0.05011146,0.04149568,0.05874608,-0.095443636,0.045632802,0.08731528,-0.13888854,-0.012324741,-0.012404643,-0.06415234,0.027636759,0.0061037964,-0.011105876,0.04641276,0.04944687,0.017525954,-0.043688092,-0.049855422,-0.11411008,0.012407686,-0.031888597,0.009460101,0.016852796,0.048872318,0.042633977,-0.010796541,-0.0011334188,0.017327586,-0.016154107,0.030275801,0.03539617,-0.008136108,-0.057828218,0.025653124,0.00894275,-0.00415707,-0.028682474,0.05485052,-0.08995108,0.012039018,-0.069751896,0.046217814,-0.05876694,0.05692298,0.057715822,-0.051858097,-0.014956183,0.0123156505,0.011288202,-0.04709707,0.031786304,0.054826003,-5.0960843e-08,0.071933985,-0.1241625,0.008193749,0.015563262,0.020907242,0.010091567,0.02511532,-0.06322964,0.0063922782,-0.08870478,-0.0039209076,0.07485037,0.026609711,-0.0048649237,0.040452894,0.0046248464,-0.067415446,0.05074636,-0.037010666,0.021647563,-0.09542122,-0.004838823,-0.11001037,-0.028246291,-0.07303082,-0.032227922,0.038042445,-0.01748874,0.07537993,-0.03804487,0.058403216,0.05532742,0.0019842905,-0.010721268,-0.13830943,-0.04050724,-0.024046695,0.03964225,-0.06322515,0.046348874,0.0019359749,-0.027060842,-0.05110295,-0.009204385,0.017054303,-0.031032678,0.0073030097,0.030955406,-0.02840271,-0.014388018,0.030014403,0.019479765,0.023241067,-0.0020921135,-0.04988121,0.08796663,0.028455315,0.009652652,-0.018136455,-0.04012221,-0.02827373,0.026153214,0.087634884,0.016723232 +1.14.15.9,"The enzyme is involved in spheroidenone biosynthesis and in 2,2'-dioxospirilloxanthin biosynthesis. The enzyme from Rhodobacter sphaeroides contains heme at its active site [1]. ",384,1.0,-0.060597442,-0.010409986,-0.07388929,0.0053201797,0.06428865,0.023259958,-0.0586323,0.09444678,0.0036120245,8.664495e-05,-0.009334637,-0.06296707,-0.014449781,-0.00013612953,0.0113144135,0.07591322,-0.09672119,0.029388273,-0.0034454106,-0.023165274,0.057929654,0.053188942,-0.09226606,0.04310182,0.03343651,-0.010643057,0.11709536,-0.03653483,-0.09100167,0.017569674,0.03707208,-0.049689826,0.047726516,-0.0019213161,0.043257102,0.08149078,0.009083211,-0.07724958,0.10111718,0.07163283,0.033267938,0.0010142786,-0.04264291,-0.046489153,-0.07605038,0.026665661,-0.010213986,0.022841584,-0.03092353,-0.030501492,-0.06375216,-0.012112221,-0.06819006,0.02727992,0.050282948,0.034749225,-0.017147593,0.022004459,-0.02262324,-0.03337257,0.04613481,-0.063173674,-0.01235551,0.026892712,-0.061276738,-0.13977307,0.041629717,-0.04775524,-0.022697834,-0.06480232,-0.020001955,-0.0033980757,-0.023155335,0.0015350557,-0.048529044,0.064660065,0.010013424,0.0012253418,0.048326112,-0.048054155,0.0071310564,-0.027535114,0.026607234,0.109611504,0.021118626,0.0023091566,0.033508144,0.023576476,-0.03865814,0.06437683,0.054486204,0.028165737,-0.002702861,-0.07908928,-0.1096201,0.06444675,-0.0022985786,0.05372557,-0.0041073863,-0.008674077,-0.025701772,0.011526089,-0.0021329005,-0.084238544,-0.01312998,-0.037547987,-0.026213929,0.04458879,0.05749405,0.033420097,0.04161982,-0.02685509,0.062962584,0.019207735,-0.0141944075,0.12160671,0.040166207,-0.03342445,-0.08790652,-0.023183553,-0.01515664,-0.036017723,0.026321525,-0.0051760483,-0.045836538,0.01526594,-0.070654094,4.303615e-33,0.06620092,0.03371891,0.024290962,-0.011620648,-0.06122968,0.020909894,-0.113554895,0.056590635,-0.009035349,-0.05809816,-0.11767239,-0.038670253,0.04172324,-0.038490802,-0.056279458,-0.009964695,-0.0547692,0.013771569,0.03579382,0.08640834,0.011238649,-0.04025578,-0.06762367,0.006796907,-0.016410057,0.03522072,-0.0016813687,-0.100284316,0.0066844937,-0.00093941705,-0.00011805684,-0.105486535,-0.034900445,0.00508028,0.008257565,-0.11299274,-0.03231891,-0.035938073,-0.07469934,0.014108287,-0.024625236,-0.007542163,-0.013085765,-0.033149105,0.06109162,-0.017385336,-0.060323283,0.010354284,0.075186886,0.1449574,0.0074295946,0.00114625,0.16755219,0.001771607,-0.023146784,-0.020577855,-0.022189977,0.022227827,0.11402511,0.02857991,0.04776877,0.085293606,0.010656059,-0.0083779525,0.057901893,0.037973236,-0.04785754,-0.03087077,-0.023250632,0.036218297,-0.013801387,-0.03399909,0.063378714,-0.03877318,-0.009655143,-0.053914234,-0.019968702,-0.012877849,0.024474762,-0.0352599,-0.0065672593,-0.0096358135,0.060424678,-0.028070642,-0.022787044,-0.033214096,-0.0042117066,-0.012876451,-0.078676164,-0.0013256634,0.06707448,-0.11115094,-0.10825672,-0.02021606,0.042477522,-4.5820777e-33,0.087600626,-0.07585556,0.007770168,-0.13374381,0.040959172,0.08781438,0.013232956,0.0059931437,0.0061567086,-0.012418495,0.09199594,-0.0070124813,-0.034946363,0.038945716,0.012925556,-0.0074314196,0.0140676275,0.019941911,0.0021904893,0.006196978,-0.015892161,0.026552388,0.027731318,0.06902437,0.029347893,-0.029171517,-0.019455614,0.04040042,0.004183308,0.062006675,-0.005235122,0.04780494,-0.049836647,0.029307202,-0.023198595,0.02029118,-0.0022703074,0.036400136,0.04019082,-0.024328765,-0.019208679,-0.02539541,0.015786966,0.1347017,0.038831875,0.038494423,-0.119602464,0.036154054,-0.056481898,-0.03696988,-0.06710208,0.07222,-0.03078378,0.016704794,-0.0034604426,0.017954834,-0.055601817,0.051212143,-0.046281777,-0.045359343,-0.07559154,-0.034537904,0.01464029,0.074851386,0.007781057,0.12731577,-0.055858847,0.10121365,-0.031164931,-0.026382016,0.04513047,-0.006293233,-0.028417742,0.0373709,0.015620678,-0.07257489,-0.023848852,-0.059955385,0.026967391,0.06904918,0.0048909727,0.01557572,0.0014668548,-0.03336847,-0.0072547817,-0.05984082,-0.013862754,0.018299717,-0.055975642,-0.035630364,-0.031162597,0.04091128,-0.041822996,0.04951138,0.071892105,-3.4457624e-08,0.015380537,-0.09760988,0.0795158,-0.044617683,0.05221833,-0.019201342,0.0037651474,0.04505402,0.051040657,-0.0071705272,-0.010234049,-0.018865254,-0.017260987,0.008012778,0.11856891,0.06177297,-0.05018806,0.008306122,-0.030678531,0.021492613,-0.0089633195,-0.018618947,-0.09713841,0.05394322,0.05493502,-0.038839694,-0.0006488885,-0.045519207,0.021210972,0.011993796,0.071426,-0.015133956,-0.013617226,0.03955229,-0.031335395,-0.012693279,-0.029585354,0.04193629,-0.041671187,-0.025102956,-0.004223525,-0.0521949,-0.056713697,0.0009781419,0.053251237,0.070842214,0.0046083312,0.017976834,0.057524294,-0.008181633,-0.027399227,-0.002200751,0.0018833923,-0.046023253,-0.1378401,-0.0031400966,0.030813316,-0.03198602,-0.056828395,-0.015281918,-0.020511575,0.10572145,0.2213315,0.01829143 +1.14.15.10,A cytochrome P-450 monooxygenase from the bacterium Rhodococcus sp. NCIMB 9784.,384,1.0,-0.12228532,0.006101078,-0.104248755,-0.01995922,0.0259933,0.06771223,-0.10119592,0.033335023,-0.037815753,-0.010392497,-0.030634407,-0.06810702,0.046862774,0.03815204,-0.0484092,-0.019673232,-0.04565311,-0.06639501,0.040118515,-0.011919398,-0.013835247,0.03484132,0.0021976407,0.007804168,0.0055613476,0.051399663,0.06623898,-0.0074762385,-0.1207785,-5.7482033e-05,0.031996693,-0.03815344,0.06700459,-0.079661764,0.053053487,0.07118833,-0.05101273,-0.020406319,0.09672829,0.005560083,-0.042167917,0.04091468,-0.002355216,0.041097604,-0.039534703,0.002383617,0.002099081,0.03392577,0.090294816,-0.05496829,-0.01715305,0.008864022,-0.09531837,0.0350047,0.081696525,-0.021724917,-0.029354058,-0.083624184,-0.052841607,-0.023547709,-0.011782554,-0.011695473,0.009259565,0.075860195,-0.031315688,-0.040370993,0.022190293,-0.033238053,0.016394967,-0.05905219,-0.059323415,-0.031931296,0.010270723,-0.054421585,-0.088822655,0.070708096,0.0589509,-0.039813466,0.024739308,-0.010286546,-0.03364816,-0.010504747,-0.027899846,0.058170807,0.04872812,-0.03739277,0.041294754,-0.021167185,-0.029960865,0.03542898,0.043539412,0.0075477404,0.01676758,-0.063473575,-0.084790185,-0.014678406,-0.0012613465,0.05521084,0.009836432,-0.058581587,0.033829708,0.043938257,0.04108552,-0.09172774,-0.05128473,-0.033385582,-0.027330894,0.14162324,0.06536769,-0.02552811,-0.011951561,-0.005882456,-0.040483356,-0.0074521597,0.030562848,0.07932725,0.033501808,-0.07351446,-0.12211517,0.045818634,-0.038721327,-0.06854165,-0.007997897,-0.038571075,-0.064790726,0.033667617,-0.063350484,1.4158545e-33,0.03647429,0.0033800509,-0.011636725,-0.009664558,0.018541222,0.0765901,-0.059989184,0.039394893,-0.038118955,-0.022326406,-0.023236286,-0.019328328,0.048066683,-0.0014399312,-0.09544244,0.05156312,-0.064258985,-0.02466072,0.0022789873,0.030065482,-0.04527056,0.029644674,-0.01324335,-0.0104117,-0.008283799,0.09681565,-0.03748566,-0.036988158,-0.00885093,0.018855302,0.01490143,-0.06267793,-0.07738199,-0.024609858,0.022573914,-0.044933714,-0.014710429,-0.027634557,-0.034379594,0.00566138,-0.054573245,0.0010037775,-0.0022504905,-0.06994462,0.049790762,-0.024983156,-0.083962694,0.105392165,-0.016493483,0.12943077,0.013008715,-0.019283567,0.078205556,0.025404347,-0.041166462,0.007747576,-0.016609825,0.040124442,0.036675423,0.038220726,0.09189271,0.1233919,-0.023055715,0.065329656,0.10439803,0.0065070395,-0.00084443344,-0.015950963,-0.0019949947,0.13525875,0.0045993817,0.024568755,0.061291378,-0.028574103,0.031683203,-0.01463046,0.01240697,0.041647766,0.05966191,0.037125576,0.020539997,0.035052113,0.04914206,-0.052162148,0.018936712,-0.0054017515,0.037261017,0.0049529914,-0.02488372,0.0772878,0.077063166,-0.102026425,-0.034737036,-0.045812503,-0.06961765,-2.9814432e-33,0.12125523,-0.069106035,-0.030386362,-0.1091118,-0.043029096,0.05770668,0.056812916,0.009832148,-0.0825539,-0.029652767,0.13344367,0.017320618,0.043611553,0.061156135,0.060040683,-0.059157405,0.004909383,0.031990502,0.008381783,0.048494097,0.025995959,-0.030235609,0.0050497367,-0.04109797,0.047346715,0.015208208,-0.029474631,0.02766786,-0.00044542897,-0.015107553,-0.08842716,0.07851297,-0.0911253,-0.022935396,-0.013187462,0.037043445,-0.022941442,0.021763368,0.05300161,0.04179677,0.019011516,0.08026668,-0.064392395,0.044025842,-0.0047045103,0.020412294,-0.116376035,-0.017639311,0.01505553,-0.040797036,-0.028589902,0.016290337,0.0005550073,0.0098185595,-0.012516196,0.033134136,-0.02059774,0.006806873,0.031574093,-0.03218494,-0.08213122,-0.04107427,-0.008459074,0.062112067,0.011572503,0.05610077,0.017684802,0.024933122,-0.0052967938,-0.033720348,0.017027084,0.0053304564,0.07166744,0.0009894958,-0.05717334,-0.012360426,0.014101295,0.018918337,0.012409264,0.071770824,0.1137763,-0.02437718,-0.02057252,-0.023396937,-0.0379927,-0.11309755,-0.022633692,0.031521466,0.020549309,-0.07467696,-0.00313884,0.06235663,-0.025865601,0.018578127,0.11987951,-2.1727e-08,0.0050944537,-0.025307808,0.11757322,0.009343324,0.113815255,0.07711008,-0.019118296,-0.0923973,-0.009190384,-0.0040546097,0.11405421,0.012389499,-0.020668631,-0.0044634817,0.018347302,0.04351273,-0.08863121,-0.045359053,0.058736667,0.06699353,-0.06774318,-0.03391274,-0.052545946,0.04752894,0.029257257,-0.059930716,0.0459815,-0.062228795,0.0042197043,-0.03799079,-0.04282638,0.0071273474,-0.03590347,-0.018110495,-0.050071176,-0.098409,-0.029739993,0.014984917,-0.06783857,0.015490435,-0.022361238,-0.011002927,-0.0815497,0.00056927145,0.03889177,0.019613465,0.00039874073,0.009751843,-0.04767525,-0.0066910447,-0.033784267,0.022139195,0.039957236,-0.06427117,-0.08410649,0.03361206,0.060875166,-0.06583941,-0.09969214,0.004048729,-0.006745696,0.072010145,0.11469016,0.0039307247 +1.18.1.5,"Requires FAD. The enzyme from Pseudomonas putida reduces putidaredoxin. It contains a [2Fe-2S] cluster. Involved in the camphor monooxygenase system (see EC 1.14.15.1, camphor 5-monooxygenase).",384,1.0,-0.0428178,-0.008340658,-0.036427975,0.005592171,0.0891165,0.05038943,-0.1069674,0.067456745,-0.005332759,-0.06544439,0.021866769,-0.06578482,-0.022442544,0.07524929,-0.002543845,0.042320102,-0.03187672,0.040656272,0.007789026,-0.0355593,0.012019595,0.07086672,0.0019437808,0.008163918,-0.042870425,-0.015842143,0.018500382,-0.018059023,-0.0021976714,0.0043977103,-0.04288063,-0.060092717,-0.022918206,-0.091312565,-0.027226787,0.03691511,0.036278598,0.0028816245,0.020088432,-0.019808782,-0.05932265,-0.034953307,-0.0113336565,-0.034335967,0.011510626,-0.07593868,0.04044292,0.025890805,-0.009778456,-0.078698546,-0.058659695,-0.021824542,-0.0046635126,0.025736686,0.0793524,0.013418271,-0.0410451,0.0075333114,-0.03961788,0.020546382,0.0058008316,-0.026647273,-0.011083734,0.019688033,0.04784854,0.0007706336,0.010232911,-0.021071931,0.004650834,-0.033529676,0.06859929,-0.054498304,0.07081487,-0.0042849514,0.0072888914,0.055062164,-0.02497134,-0.016942112,0.09565174,-0.02174541,-0.0006530388,-0.013044668,0.041895576,0.11247813,-0.0110648535,-0.037756458,0.023942653,-0.00053263066,-0.06623834,0.07349519,0.056533653,-0.02679747,-0.06430139,-0.06277483,-0.022480689,0.03161868,0.02695998,0.07356071,-0.006890993,-0.028717777,-0.03759074,0.027635742,-0.06832661,-0.02841627,-0.059376296,-0.03410088,0.08060719,0.043691896,0.023698078,-0.009368813,0.061862957,0.040823247,-0.036627606,0.028146166,-0.054527074,0.040095437,0.08778866,-0.09726211,-0.042832423,0.012590048,-0.038685303,-0.01712759,-0.0107236365,0.10514612,0.037440013,-0.010087853,-0.08942633,8.933069e-34,0.03541013,0.015475022,0.00286253,-0.02728177,0.058235046,0.017178291,-0.1133056,-0.037846696,0.014572835,0.015580521,-0.0631628,-0.085639715,-0.004256945,0.0035284723,0.04345543,-0.087898955,-0.07233514,-0.04951154,0.096617006,-0.08402494,0.05513559,0.03171881,-0.038778257,-0.024895925,0.037592433,0.04101888,0.037782945,-0.038580824,0.0015507118,0.037474666,0.0073301536,-0.07029413,-0.10196924,-0.04821341,-0.025284646,0.0061480044,-0.034602057,-0.017891916,-0.08080738,0.0077162804,0.071979165,0.095913984,-0.10249546,-0.020437747,0.11630937,-0.15652044,-0.04667302,0.17286587,0.04943442,0.1296451,-0.000976996,-0.06818271,0.047703855,0.046670604,-0.06374362,-0.007949386,-0.030228851,0.014449091,0.06859784,0.057597842,0.046894457,-0.013114363,-0.013318333,0.043160252,0.08129418,7.1530696e-05,-0.034102987,-0.004762587,-0.029101064,0.038800284,-0.052388996,0.016912002,-0.002825022,0.024842763,-0.05127257,-0.088618085,-0.008349392,0.04449898,0.038949672,-0.025807278,0.0375878,-0.082384415,0.017687002,-0.013233925,-0.018407729,0.04295248,-0.032418862,0.0009871842,-0.02130677,0.030020203,0.10708906,-0.06885146,-0.015201342,0.043420743,-0.028844364,-1.2353695e-33,-0.0037889478,-0.09023079,0.11304564,-0.074782744,0.027728079,0.04034759,-0.012437036,-0.022442954,0.09404118,-0.00322416,0.049985453,0.0036660065,0.03156498,-0.052824877,-0.0073539834,0.023718601,-0.06339525,0.0054181344,0.05411496,-0.00064073753,-0.045527942,0.026682772,-0.018231105,0.103500545,0.08798276,0.09205281,-0.0705917,0.0928368,-0.008012984,0.086448036,0.07654158,0.02300906,-0.079741746,0.032035984,0.026762486,-0.023838472,-0.027427135,0.08636914,0.025094086,0.06689783,-0.023593577,0.04178578,-0.06623457,0.10277665,0.0049478034,0.08171058,-0.09541696,-0.03449526,0.06302787,-0.12166416,-0.013524958,-0.021685854,-0.039728727,-0.011543639,0.026804693,-0.039856788,0.023337396,0.011879233,-0.034957245,-0.035707396,0.028527113,-0.06484518,-0.016190398,0.011276173,0.086698845,-0.03733792,-0.050905284,0.064454935,-0.032415822,0.04457724,0.022754192,-0.020748029,-0.024937803,0.012158514,-0.074986726,0.010294992,-0.017039515,0.011694675,0.060871866,0.04843778,0.039852366,0.005073383,-0.07240687,-0.05257381,0.029102257,-0.022940986,0.057107363,0.12842262,-0.016780099,0.024857307,-0.050336856,0.063635215,-0.0030418267,0.0010617354,0.042436387,-3.4091073e-08,0.06902737,-0.10040126,0.031060994,0.040944442,-0.04196572,0.010929471,-0.038211014,0.040284738,0.017777877,-0.062302236,-0.027122298,0.06867427,-0.0027045792,-0.04006283,0.06296884,-0.080332935,-0.04762669,0.030280154,-0.041313294,-0.047091432,-0.1058967,-0.034808584,-0.042610064,-0.0054823565,0.0069320356,-0.05171292,0.076932825,0.017631182,0.041669555,-0.034336895,-0.020247476,-0.04268483,-0.030184621,0.013702486,-0.10594063,0.08616004,0.019542351,-0.0015176419,-0.054234255,0.025474682,-0.026410336,-0.049879342,-0.032340467,-0.038427483,0.037054155,0.006914514,0.021221332,0.036451455,-0.025949888,-0.051566526,0.055510692,-0.018875582,-0.0133774355,0.022415355,-0.077998206,0.035598766,-0.03532963,0.007761503,-0.00519866,-0.059258126,0.0166626,0.055235688,0.13790339,0.015785502 +2.1.1.256,The enzyme specifically methylates guanine6 at N2 in tRNA.,384,0.99999994,-0.03824922,-0.08467856,-0.12202903,-0.021571146,0.00034207333,-0.016012158,-0.017216407,0.013328964,-0.0411291,-0.061538447,0.0748204,-0.02322064,-0.13170184,-0.02731465,-0.055563528,0.056841683,-0.079196095,-0.03667948,0.04048152,-0.017962534,0.026864534,0.07932592,-0.0035365596,-0.008909985,-0.007520718,-0.00986037,0.03927849,-0.027866464,0.078825556,-0.047460865,-0.05438616,0.049818594,-0.025608892,0.07028281,0.001944186,0.10442346,-0.09007767,0.017373247,-0.0020909237,-0.009531106,0.07975047,0.024711728,0.0081524765,-0.045156505,0.016591167,-0.024660358,0.04155796,0.008133714,-0.005612421,0.03372302,-0.0086417645,-0.083716355,0.0074050482,0.027281554,0.01505069,0.030174486,-0.091749966,-0.039594363,-0.015765334,0.05967247,0.06545967,0.0051166103,-0.0011886172,-0.07710544,0.10737042,-0.016961925,0.05822754,-0.0054392163,0.02592158,-0.054853458,-0.028502075,-0.018439518,-0.037901387,0.045848023,-0.0961851,0.07201258,0.021077996,-0.06314232,0.035519768,0.0047934866,-0.02409026,0.025659733,0.05253504,0.018945394,0.10361705,0.02197128,-0.007908667,0.08876691,0.02075408,0.059406076,0.08306375,0.08331072,-0.002096009,-0.050079543,-0.08034862,0.056428358,0.016615236,0.020194504,0.028489726,-0.016122995,0.0033613378,0.050118413,-0.062966354,-0.03261772,-0.0300728,0.0043209055,0.05024135,0.024262404,-0.02155108,0.027082376,-0.039798267,0.11238721,0.040885538,0.011392239,0.009558306,0.06380135,0.025788886,0.02078937,0.027951565,0.009741205,-0.06763506,0.07350709,0.018414466,-0.00048335243,-0.054470226,0.00847012,-0.087926306,2.3500478e-34,0.030366467,0.0026633465,0.0123454975,-0.011996001,0.072489135,0.028773215,-0.09522981,-0.00089337793,-0.03685849,-0.013433507,-0.10528429,-0.09515643,0.011792528,-0.019748813,0.007683766,0.020762673,0.0032548518,-0.0032344633,0.059856195,-0.13073148,-0.006116094,0.028395137,-0.03938078,-0.013699977,-0.015073268,0.03569822,0.045724567,0.005447793,0.049853522,-0.04498831,-0.03507104,-0.087670885,-0.008279274,-5.258827e-05,0.08993486,0.028208153,-0.028761748,0.050668083,-0.062844835,0.065915436,0.07299483,0.032996785,-0.00045355546,0.03251018,-0.04743424,-0.03539651,-0.037862256,0.023366127,0.051213633,-0.0012585894,0.013908154,-0.048474353,-0.009121157,0.004772419,-0.017580876,-0.0071266494,-0.0061585787,-0.015461598,0.028970154,0.02666928,-0.014144947,-0.031005315,0.012247757,0.03137208,-0.029741928,-0.00921728,-0.12945078,-0.059887834,-0.0004226206,0.066065,-0.043509986,-0.06239956,0.13886027,-0.012937937,0.039929435,-0.043310862,-0.09202226,-0.06033252,0.0085167745,0.031931255,-0.028995028,0.031420622,0.03287818,-0.0152279,-0.08527013,-0.028534781,-0.00037170877,-0.05754976,0.038867664,0.037980296,0.04553455,0.00014043364,-0.078794174,-0.054168023,0.014285251,-5.6097998e-34,0.04760716,-0.055708725,0.0798001,-0.043912925,-0.022629596,0.020451244,0.03246644,-0.087995216,-0.03782078,-0.06888791,0.14735556,0.023696166,0.027452853,0.008591401,0.07695204,0.025779855,0.0112522775,0.06352961,0.03164214,-0.060208052,-0.017022131,-0.008067178,-0.055133864,0.04558188,0.014400184,0.02129722,0.055653643,0.043240454,0.058273096,0.032586385,-0.08233264,-0.005604557,-0.036876462,0.04978435,0.013422084,0.0177419,0.020362474,-0.014892049,-0.041662898,-0.0069371364,-0.022593835,0.011764484,-0.014110797,0.13320972,-0.008080414,0.043299798,0.024480335,-0.06982089,-0.10235063,-0.023268396,0.10895465,-0.008678635,-0.002499933,0.025533082,0.06842076,0.0067253066,-0.030153573,-0.07081429,-0.026250122,0.0017727322,0.035958722,-0.058191035,-0.08895279,-0.06289846,-0.0020042802,0.033878095,0.004472754,0.10190415,0.021767354,-0.02708557,-0.011742722,0.02296519,0.02287858,-0.0061800946,-0.07006312,-0.07877885,-0.017934026,0.018119102,0.04734579,-0.12566939,-0.0029965437,0.040900607,-0.05562298,-0.0470437,0.018017482,-0.013371659,0.07557837,0.14229119,0.019433513,0.06329249,-0.03700288,-0.016979603,-0.07789021,0.053770643,0.05002538,-1.9404892e-08,-0.02678079,-0.113876656,0.018367816,-0.033481237,0.022258408,0.110238224,-0.040486846,0.06543413,0.01812652,-0.0042816405,-0.034395695,0.032539707,-0.01838592,0.049953435,0.0030951207,0.031297516,-0.05192628,0.01876257,-0.005064099,-0.048688613,-0.07454418,0.09072974,-0.12134899,0.0102974,-0.0209294,0.0007596044,-0.032638963,0.14246014,0.013877689,-0.03486541,0.03472846,-0.0036259561,0.06238035,-0.035093322,-0.012560264,0.058805954,0.04995776,-0.08580494,-0.043935843,0.017705645,0.019459596,0.019111773,-0.04897578,-0.014220599,-0.07679807,-0.033799592,-0.022745071,0.078581914,0.0037621662,0.08229729,0.07390236,-0.003314858,0.033334695,0.012091303,-0.034421317,-0.023394255,0.015081435,-0.09113253,-0.08713996,0.0012969011,0.031749234,-0.06425272,0.12752217,-0.04667418 +2.1.1.257,"While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54 [2,3].",384,1.0,-0.0008088827,-0.016105125,-0.07600307,-0.10767576,0.037819788,0.023889028,-0.11581261,-0.0025331383,-0.024547337,-0.02619984,0.022554368,0.0070066997,-0.03564926,0.037489545,0.0016590699,0.0069071962,-0.07692211,-0.015340761,0.045039397,0.04482627,0.029837064,0.04929196,-0.008679991,-0.009816912,-0.022697758,0.055604167,0.04142812,-0.014008638,0.0091899345,-0.020855932,-0.05576535,-0.017971007,0.10747985,-0.05860132,0.04155603,0.06555491,-0.085948296,-0.0011814096,0.052203953,0.043163337,0.09155529,0.030451393,0.01834474,-0.012717383,-0.05865856,0.020308217,0.029191516,-0.0033708275,0.004860443,-0.03747103,-0.07448767,-0.032011785,-0.046163265,0.07656984,-0.060301196,0.102997854,-0.040306833,-0.07345348,-0.008577299,-0.031358477,0.029755386,0.0038269951,0.022524133,-0.032807536,0.08111197,-0.05123283,0.10180284,-0.08465438,0.028802268,-0.025982963,-0.021151194,-0.01739246,0.007059935,0.05117619,0.022780389,-0.03228455,0.03353998,-0.060746394,0.031169225,-0.095475346,-0.058486313,-0.062183235,0.0075599975,0.05224007,-0.013186142,-0.026660006,-0.028535984,0.03541778,0.066922,-0.0046484843,0.077814564,-0.0120947035,-0.0664311,-0.08035284,0.0039527756,0.049163092,-0.009842646,0.06707584,-0.0038791236,-0.056301273,0.053788673,-0.022223417,-0.15654127,-0.06623341,-0.002597772,-0.031346798,-0.017663078,0.09353051,-0.025612751,0.01145729,0.029784335,0.04657225,0.04710168,-0.0139204115,-0.015639449,0.0611814,-0.00033366727,-0.108032264,-0.032609988,-0.044791218,-0.030664312,-0.052780308,0.108344935,0.058695827,-0.022747856,-0.016823001,-0.11082164,2.4884016e-33,0.018986851,0.0007361694,0.049437772,-0.09484175,-0.021482995,0.04367798,-0.059096187,0.015605954,0.019365085,-0.10703956,-0.07091732,-0.11281343,0.052782193,-0.044094745,-0.07797516,-0.028515918,0.05394152,0.053452928,-0.018580776,-0.03601579,0.0556951,0.109348886,-0.038900435,-0.040490855,0.058944955,0.03465193,0.029095428,-0.057820015,0.029328393,-0.00088338717,-0.025762914,-0.098164774,-0.126027,-0.034530163,0.116518684,0.07301927,-0.0709182,-0.015915679,-0.06222678,0.061415978,0.019978855,0.09673409,0.019978782,0.034598462,0.05007948,0.020978764,-0.019468592,0.11503296,-0.012132563,0.09025492,-0.023875935,0.0040541794,0.035991378,-0.018343067,-0.0606893,-0.032809306,-0.00749413,0.0031801898,0.01232326,0.016181005,0.0156501,-0.012909959,-0.011666197,0.07264025,0.010306272,0.009030824,-0.050864264,-0.049395032,0.06538393,0.1025035,-0.043923132,-0.028259039,0.06962704,0.06380776,-0.013328622,-0.050064247,-0.03618319,0.0017452957,0.034267873,-0.055001717,-0.027344538,-0.021530626,-0.018821249,0.03954463,-0.054252777,0.027958749,0.029805575,-0.024292389,0.015432384,0.048094217,0.0964997,-0.076625116,-0.019956823,0.0728693,-0.018209498,-3.914747e-33,0.032676022,-0.11774713,0.06406889,-0.06116324,-0.032108855,0.040351626,0.053594425,-0.036012106,-0.037595194,-0.068030626,0.112080425,0.051765583,-0.031444218,-0.02672045,-0.0028327587,0.05915765,0.017520275,0.0015290321,0.015373092,0.06714451,0.018077528,0.027849084,-0.06524952,0.15583864,0.06350208,0.039009336,-0.00038532098,0.06075645,0.04805957,-0.025245437,-0.047966354,0.07648323,-0.046977412,-0.08786727,-0.016797505,0.03541319,-0.07941413,0.012817754,0.01821286,0.06337269,0.0044817063,0.057393827,-0.07312095,0.0813799,-0.028197737,0.076887466,-0.016865857,0.029550582,0.03332432,-0.05812038,-0.048543297,-0.05656531,0.04035336,0.008000336,0.057598792,0.024544246,-0.08986123,0.07580612,-0.029263102,-0.032058876,-0.01427758,-0.028587222,0.00035727327,-0.07811162,-0.0010392756,0.020469792,-9.3054085e-05,0.054355938,-0.026612012,-0.061722077,-0.055187583,-0.010121327,-0.0119071845,0.0656888,-0.08298286,-0.045858562,0.049223516,-0.018838467,0.04806492,0.021244518,-0.060061317,0.06594475,-0.020254621,-0.021784212,-0.035440713,0.0011494985,0.09027452,0.019790234,-0.06897818,-0.01393096,0.0013754502,-0.029000148,-0.010400297,0.023750465,0.040599298,-3.254578e-08,0.054009672,-0.068697825,0.07664191,-8.368073e-05,-0.0782582,0.06487524,-0.036261547,-0.032293215,0.005679004,-0.0318351,0.010900096,0.027057132,0.017182507,0.0067014378,0.0006298825,0.004196423,-0.07733341,-0.010574547,-0.04788321,-0.05089802,-0.066166215,-0.008662806,-0.08513786,-0.018434638,0.045352012,0.038845785,0.015725145,0.046074566,0.021274295,-0.051531434,0.009120202,-0.011533775,0.041088473,0.023581218,0.00840465,0.0736196,-0.00862656,0.00012327354,-0.0146565875,-0.0063349865,0.044175826,-0.07418225,-0.048002124,0.039317437,0.037147637,-0.037417445,0.017724387,0.020389637,-0.018426843,-0.02617453,0.033227913,-0.015623175,0.048946332,-0.031680007,0.009797543,0.014126121,-0.029686566,-0.10834247,-0.10564032,0.028301997,0.10552646,0.005432751,0.07546061,-0.024569985 +2.2.1.10,"The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.",384,1.0,-0.06403686,0.005199207,-0.01762537,-0.08025775,0.019945279,0.046581216,-0.10842577,0.01445011,0.07072931,-0.017129092,0.008236942,-0.05845638,-0.07473123,-0.040260553,0.015030011,0.08160754,-0.09551843,0.03417304,-0.017273683,-0.08413467,0.072548024,-0.014964214,-0.014597481,0.0020042094,0.065504804,0.032783315,0.036879852,0.0279131,-0.042786837,-0.033255905,0.04182956,-0.047254976,-0.012788173,-0.06867858,0.0070929793,0.11287821,-0.05246317,-0.08143025,0.065544866,0.056199446,0.06313711,-0.024017926,-0.022679843,-0.03474211,0.02458201,-0.00424523,-0.020031855,0.06654458,0.05035885,-0.027236305,-0.04119365,-0.06668916,-0.012281998,0.050057236,0.082488246,0.026425349,-0.041047078,0.06977554,-0.055036012,0.055430125,0.012715616,0.017752731,-0.055588484,0.021838998,0.02927218,-0.0078378385,0.01342155,-0.11521784,0.022662804,-0.04265457,-0.015239802,-0.10970525,-0.026209535,-0.037795573,-0.0017595554,0.056416865,-0.07799511,-0.045213133,-0.011730862,-0.04163987,0.06967865,0.012631519,0.04462917,0.06019307,0.07516597,-0.04155046,-0.0008028177,-0.059990022,0.011529748,0.0040669474,0.0056448653,-0.08865781,-0.04570914,0.007888678,-0.043294705,0.07949651,0.05509946,0.035189226,0.048003085,0.012357275,0.03498262,0.1153424,-0.06930908,-0.10595512,-0.059599724,0.07434111,-0.0025384657,0.08140045,-0.063807815,-0.007200307,-0.03346672,-0.053359196,0.055939745,0.010551673,-0.040460706,0.11351505,0.057367735,-0.045475718,-0.017545931,-0.048340004,-0.013455979,0.015590264,0.0872467,0.09251899,-0.03407543,0.02651923,-0.089637,3.4377043e-34,0.0965046,0.0014120598,0.029862389,-0.06801108,0.022136685,-0.0126751745,-0.06477239,0.074871734,-0.1013594,-0.049991325,-0.025666175,-0.068267584,0.08814351,-0.0143065825,-0.04214936,-0.05458458,-0.022242708,-0.021708693,0.064208075,0.029144714,0.007532552,-0.024883227,-0.044870734,0.04308742,0.013934437,0.0574669,0.019493982,0.030014765,-0.0011163378,0.008607053,-0.054967422,-0.09170561,-0.1070235,-0.07234823,-0.034109637,-0.027443362,-0.1036513,-0.02409642,-0.03134867,0.047398135,0.008586802,-0.0033402336,0.011034828,-0.07283885,0.028255664,0.06849086,-0.008159597,0.06477352,0.052717045,0.039554,0.08447399,7.555788e-05,0.10364131,0.023263212,-0.088695526,-0.013516502,-0.029771902,-0.046983458,0.010969279,0.026644545,-0.029732797,0.038046885,-0.014036322,0.02037536,-0.0023983081,-0.032490615,-0.04681295,-0.011425005,-0.007550754,0.098601356,-0.040518623,-0.011550519,0.043002512,-0.041947052,0.05805359,-0.04143075,-0.116432816,0.007053175,-0.00013677802,0.012739532,0.0060781026,0.024001988,0.05726659,0.009711206,-0.043649737,-0.028652426,-0.014383367,-0.0021240949,-0.032759137,0.058027647,-0.012848474,-0.01808678,-0.02160075,0.03357073,0.035165288,-1.6863684e-33,0.06934325,-0.0871694,0.010644627,-0.09002189,-0.048696436,0.025173537,0.022699513,-0.019980006,0.090179354,0.017134488,0.0801179,-0.022275977,0.07144957,-0.08302173,0.047199093,-0.026356913,-0.12735733,0.088971145,0.0027650518,0.04078629,0.10804767,0.1073932,-0.026264286,0.023759957,0.05727182,-0.00026998195,0.0107641015,0.039761465,0.061036758,0.07097598,-0.041890606,-0.008998485,-0.044254795,-0.006546354,-0.007723633,0.07898972,-0.054923445,0.056981992,0.012207707,0.08409396,0.0102324765,0.055524454,0.038148973,0.044812575,0.08744348,0.073915526,-0.003835342,0.03987456,-0.03992464,-0.01886834,0.05192184,0.00019006057,-0.033671126,0.034002244,0.04759664,0.049982235,-0.014516597,-0.029626977,0.010275791,-0.04168502,-0.075389616,-0.049436986,0.06815447,-0.022443492,0.006076095,0.03165799,-0.05822315,0.030358125,0.026060918,0.009133236,0.06654891,-0.007710261,-0.026357874,0.102036424,-0.006162452,-0.065039314,-0.11283322,-0.014474631,-0.029725978,0.024720963,-0.008793819,-0.0037277022,0.011962566,-0.03459279,-0.023668617,-0.08851399,0.054478742,0.07497023,-0.08229779,0.031802777,-0.028069269,0.0065537905,-0.042416755,0.084280044,0.049534287,-3.4042205e-08,0.012667983,-0.021846166,0.032565802,0.028706448,0.0013636175,0.0014439466,0.04542316,0.05240635,0.022360913,-0.009394071,0.040838588,0.038273774,0.02949849,0.04006595,0.025670085,-0.012348811,0.0030412436,-0.0059275646,-0.02931315,-0.049133983,-0.022829078,-0.0029161382,-0.09263359,-0.008621596,0.021174815,-0.038424857,0.0121971555,0.049426354,-0.013853321,0.0069662137,-0.002427865,0.018453581,0.021664338,-0.06535118,-0.046348687,-0.029556403,-0.06151902,-0.050111253,0.03583331,-0.059514847,-0.033601638,-0.073233746,-0.049143426,0.03719039,0.0056211683,-0.016485604,0.035161674,0.0020393783,-0.014856457,0.068449356,0.038482185,-0.050375495,0.07617673,-0.04763087,-0.080653645,0.0054194727,-0.03767501,-0.06613618,-0.024344536,-0.10540781,0.037101485,-0.0017739873,0.18755804,-0.04414489 +2.2.1.11,"The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.",384,1.0,-0.06403686,0.005199207,-0.01762537,-0.08025775,0.019945279,0.046581216,-0.10842577,0.01445011,0.07072931,-0.017129092,0.008236942,-0.05845638,-0.07473123,-0.040260553,0.015030011,0.08160754,-0.09551843,0.03417304,-0.017273683,-0.08413467,0.072548024,-0.014964214,-0.014597481,0.0020042094,0.065504804,0.032783315,0.036879852,0.0279131,-0.042786837,-0.033255905,0.04182956,-0.047254976,-0.012788173,-0.06867858,0.0070929793,0.11287821,-0.05246317,-0.08143025,0.065544866,0.056199446,0.06313711,-0.024017926,-0.022679843,-0.03474211,0.02458201,-0.00424523,-0.020031855,0.06654458,0.05035885,-0.027236305,-0.04119365,-0.06668916,-0.012281998,0.050057236,0.082488246,0.026425349,-0.041047078,0.06977554,-0.055036012,0.055430125,0.012715616,0.017752731,-0.055588484,0.021838998,0.02927218,-0.0078378385,0.01342155,-0.11521784,0.022662804,-0.04265457,-0.015239802,-0.10970525,-0.026209535,-0.037795573,-0.0017595554,0.056416865,-0.07799511,-0.045213133,-0.011730862,-0.04163987,0.06967865,0.012631519,0.04462917,0.06019307,0.07516597,-0.04155046,-0.0008028177,-0.059990022,0.011529748,0.0040669474,0.0056448653,-0.08865781,-0.04570914,0.007888678,-0.043294705,0.07949651,0.05509946,0.035189226,0.048003085,0.012357275,0.03498262,0.1153424,-0.06930908,-0.10595512,-0.059599724,0.07434111,-0.0025384657,0.08140045,-0.063807815,-0.007200307,-0.03346672,-0.053359196,0.055939745,0.010551673,-0.040460706,0.11351505,0.057367735,-0.045475718,-0.017545931,-0.048340004,-0.013455979,0.015590264,0.0872467,0.09251899,-0.03407543,0.02651923,-0.089637,3.4377043e-34,0.0965046,0.0014120598,0.029862389,-0.06801108,0.022136685,-0.0126751745,-0.06477239,0.074871734,-0.1013594,-0.049991325,-0.025666175,-0.068267584,0.08814351,-0.0143065825,-0.04214936,-0.05458458,-0.022242708,-0.021708693,0.064208075,0.029144714,0.007532552,-0.024883227,-0.044870734,0.04308742,0.013934437,0.0574669,0.019493982,0.030014765,-0.0011163378,0.008607053,-0.054967422,-0.09170561,-0.1070235,-0.07234823,-0.034109637,-0.027443362,-0.1036513,-0.02409642,-0.03134867,0.047398135,0.008586802,-0.0033402336,0.011034828,-0.07283885,0.028255664,0.06849086,-0.008159597,0.06477352,0.052717045,0.039554,0.08447399,7.555788e-05,0.10364131,0.023263212,-0.088695526,-0.013516502,-0.029771902,-0.046983458,0.010969279,0.026644545,-0.029732797,0.038046885,-0.014036322,0.02037536,-0.0023983081,-0.032490615,-0.04681295,-0.011425005,-0.007550754,0.098601356,-0.040518623,-0.011550519,0.043002512,-0.041947052,0.05805359,-0.04143075,-0.116432816,0.007053175,-0.00013677802,0.012739532,0.0060781026,0.024001988,0.05726659,0.009711206,-0.043649737,-0.028652426,-0.014383367,-0.0021240949,-0.032759137,0.058027647,-0.012848474,-0.01808678,-0.02160075,0.03357073,0.035165288,-1.6863684e-33,0.06934325,-0.0871694,0.010644627,-0.09002189,-0.048696436,0.025173537,0.022699513,-0.019980006,0.090179354,0.017134488,0.0801179,-0.022275977,0.07144957,-0.08302173,0.047199093,-0.026356913,-0.12735733,0.088971145,0.0027650518,0.04078629,0.10804767,0.1073932,-0.026264286,0.023759957,0.05727182,-0.00026998195,0.0107641015,0.039761465,0.061036758,0.07097598,-0.041890606,-0.008998485,-0.044254795,-0.006546354,-0.007723633,0.07898972,-0.054923445,0.056981992,0.012207707,0.08409396,0.0102324765,0.055524454,0.038148973,0.044812575,0.08744348,0.073915526,-0.003835342,0.03987456,-0.03992464,-0.01886834,0.05192184,0.00019006057,-0.033671126,0.034002244,0.04759664,0.049982235,-0.014516597,-0.029626977,0.010275791,-0.04168502,-0.075389616,-0.049436986,0.06815447,-0.022443492,0.006076095,0.03165799,-0.05822315,0.030358125,0.026060918,0.009133236,0.06654891,-0.007710261,-0.026357874,0.102036424,-0.006162452,-0.065039314,-0.11283322,-0.014474631,-0.029725978,0.024720963,-0.008793819,-0.0037277022,0.011962566,-0.03459279,-0.023668617,-0.08851399,0.054478742,0.07497023,-0.08229779,0.031802777,-0.028069269,0.0065537905,-0.042416755,0.084280044,0.049534287,-3.4042205e-08,0.012667983,-0.021846166,0.032565802,0.028706448,0.0013636175,0.0014439466,0.04542316,0.05240635,0.022360913,-0.009394071,0.040838588,0.038273774,0.02949849,0.04006595,0.025670085,-0.012348811,0.0030412436,-0.0059275646,-0.02931315,-0.049133983,-0.022829078,-0.0029161382,-0.09263359,-0.008621596,0.021174815,-0.038424857,0.0121971555,0.049426354,-0.013853321,0.0069662137,-0.002427865,0.018453581,0.021664338,-0.06535118,-0.046348687,-0.029556403,-0.06151902,-0.050111253,0.03583331,-0.059514847,-0.033601638,-0.073233746,-0.049143426,0.03719039,0.0056211683,-0.016485604,0.035161674,0.0020393783,-0.014856457,0.068449356,0.038482185,-0.050375495,0.07617673,-0.04763087,-0.080653645,0.0054194727,-0.03767501,-0.06613618,-0.024344536,-0.10540781,0.037101485,-0.0017739873,0.18755804,-0.04414489 +2.3.1.198,A membrane-associated enzyme required for suberin or cutin synthesis in plants. Active with a wide range of acyl-CoA substrates (C16:0-C24:0). The enzyme from some sources has much higher activity with omega-oxidized acyl-CoAs. Some enzymes are bifunctional and have an additional phosphatase activity producing sn-2-monoacylglycerols.,384,0.99999994,-0.082704306,-0.08727652,-0.08362149,0.005566711,0.023720479,0.090230435,-0.06387187,0.055849012,0.053116336,-0.05137665,0.07439617,-0.103845775,-0.14773871,0.019709783,-0.04794411,0.023653703,-0.05765271,0.004843268,-0.040317602,-0.11258751,0.024488406,0.024150126,-0.055563297,0.026673645,0.056170445,-0.13986924,-0.04041837,-0.064785086,0.025245227,0.035176013,-0.029117275,-0.025766207,0.10672341,0.014109357,-0.026599493,0.07885244,0.015268082,-0.06387937,0.054087527,0.0035837821,0.050537746,-0.047644403,-0.04587931,-0.04386909,-0.027246654,-0.027760018,-0.028191721,-0.011719741,-0.022184575,-0.009301383,-0.02106478,-0.05776426,-0.055038035,-0.013496488,0.0118214255,0.018595919,-0.06022862,0.006054094,0.0407375,0.04421724,0.04587494,-0.04494143,0.048802234,0.032995827,0.017311037,-0.07499562,-0.06047094,0.033530843,0.04341024,-0.037378117,-0.037270058,-0.0931034,-0.05504355,0.008112377,-0.044306897,-0.031799063,-0.06653355,-0.00750369,0.008349637,-0.05823873,0.036396656,0.02629573,-0.048136424,0.09721046,0.025815174,-0.017083723,-0.0044727763,0.0226769,-0.019741151,0.0031007999,0.052020337,-0.042458344,0.019244552,0.01111983,-0.044243287,0.068876535,0.06822018,-0.065889925,0.013573752,0.013034697,-0.01771306,0.085065536,0.028085023,-0.06930228,-0.032606315,0.02494403,-0.061777994,0.013045996,-0.004352145,0.028004745,-0.0018214496,0.0125303,0.0024597696,-0.027379861,0.06174783,0.014930383,0.0161105,-0.03788391,0.01260162,0.0809312,-0.045454256,-0.035575856,-0.018695729,0.0791898,0.057880115,0.059451956,-0.063234024,2.3653979e-33,0.09672733,0.0052358997,-0.03815795,-0.009424365,0.055215303,-0.08572918,-0.03483949,0.031491034,-0.042752154,0.015730336,-0.0656145,-0.08018823,0.0029115116,0.06421818,0.039548956,-0.06866891,0.038000256,-0.03767937,0.07695509,0.009339483,-0.05965352,0.00032496764,-0.010892831,0.015024528,0.057340156,-0.04730238,-0.024372473,-0.02616967,0.060812443,-0.034412116,-0.017942527,-0.058812197,-0.029873764,0.049299262,0.030243473,-0.016430479,-0.033965226,-0.047832094,-0.04741835,0.065532945,0.043570146,0.037943095,-0.0004719602,-0.038685862,0.095119454,-0.057694506,-0.123463996,0.13567701,0.03800334,0.07257562,0.00090562174,0.00771694,0.10849702,-0.017370624,0.033509362,-0.030967154,-0.021445183,0.077959515,0.044876277,-0.013532227,0.044430465,0.04691508,-0.115866475,0.0628658,-0.025428005,0.07633467,-0.10177879,-0.0656005,0.026394244,-0.013100926,-0.053604756,-0.027898127,-0.05424926,0.07091579,0.06816446,-0.033818025,-0.034284286,0.035912264,0.013406526,0.034469124,-0.0029937348,0.054122463,0.015024893,-0.021070156,-0.04566833,-0.032728527,-0.06144719,-0.028508626,0.005811249,-0.06467163,0.03446262,-0.01106024,-0.041507076,0.05149195,0.05333587,-3.153216e-33,0.061692804,-0.10182544,0.02927166,-0.10323893,-0.026004812,0.0688027,-0.03594243,-0.064793296,0.03706492,-0.0065923007,0.057286713,0.031464107,0.0036979713,-0.037901726,-0.018752472,0.0060635842,0.0070595024,0.05847315,0.03505101,-0.027144978,-0.09092851,0.094764344,0.04395103,0.098006755,0.045261607,0.0045395973,-0.04965426,0.062849194,-0.012238456,0.035527248,-0.050420225,-0.06194998,-0.041882675,-0.0005822845,-0.022674933,0.009814739,-0.049750764,0.06578896,-0.017774293,0.035582528,0.0018383707,0.012572546,0.086856216,0.07289484,0.03309985,0.005773084,-0.048037544,0.011048859,-0.044904556,-0.06083489,-0.0019353998,-0.01248569,0.0025786667,0.045598373,0.05922052,0.096086204,0.03617932,0.01015154,0.0068681287,-0.08953259,-0.016198467,-0.07232472,0.0009455443,0.030711552,0.04465298,0.06665858,-0.08565438,-0.017640634,0.031985495,-0.026217308,0.09021244,0.013608987,0.024174897,0.0032295375,-0.043598704,-0.052011088,-0.044154484,-0.03627666,-0.06000837,0.02840389,-0.047581643,0.034910083,-0.04558731,-0.048027262,-0.043536045,-0.030202804,-0.023663765,0.020438615,0.033752084,-0.002401471,0.012002627,-0.01697903,-0.082676545,0.0511497,0.024291756,-3.7964632e-08,0.085785046,-0.04824285,0.038052764,-0.08557912,0.009741223,-0.015924064,0.057495523,-0.014141986,-0.016906036,0.0030879737,-0.05285913,0.07208812,0.0024889936,0.017489025,0.073323324,-0.026310131,0.07922334,0.13174887,-0.021753512,-0.03219181,0.02263093,-0.010144081,-0.0568594,0.07882913,-0.0062225237,-0.09207643,-0.008629785,0.0494051,0.03317217,0.009745283,0.08413368,0.035370167,0.0852032,0.0055438713,-0.02374855,0.057874236,-0.028492976,-0.081868455,-0.049367502,0.07437035,0.028338715,-0.049441367,-0.020461971,0.0025411053,0.025175449,-0.025117705,0.057132818,0.067186646,0.041874558,0.054673184,0.051394623,-0.008188725,0.00935314,-0.07836171,-0.052362848,-0.023558086,0.049431022,-0.04715945,-0.0049856734,-0.032306746,0.024378274,0.03720812,0.19381289,-0.021728126 +3.7.1.18,"Isolated from Rhodococcus sp. The bornane ring system is cleaved by a retro-Claisen reaction to give the enol of alpha-campholonate. When separate from the enzyme the enol is tautomerised to the keto form as a 6:1 mixture of [(1S,3R)-2,2,3-trimethyl-4-oxocyclopentyl]acetate and [(1S,3S)-2,2,3-trimethyl-4-oxocyclopentyl]acetate.",384,1.0,-0.0020026083,-0.080879495,-0.18127035,-0.0070385295,0.09690476,0.023629854,-0.050141606,0.009097814,0.01845482,-0.037074752,0.04069363,-0.11649255,-0.05326182,-0.012933261,-0.067390144,-0.017146442,-0.014275991,-0.0075810477,0.02555561,-8.413513e-05,0.0007543775,0.023752667,-0.031710297,0.018032182,0.0538052,0.055946678,0.11830469,0.03019996,-0.028630452,-0.067919396,0.003607094,-0.023454435,-0.012292462,-0.13508044,0.008243863,0.07573905,-0.08097384,0.021563495,0.12728006,0.011049712,-0.04414557,-0.043467313,0.043267027,-0.033662487,-0.04170743,-0.0028652453,-0.109789595,0.11198401,0.018737283,-0.044163533,0.024077844,-0.04776952,-0.08360913,0.050307795,0.05893697,-0.0021190506,-0.13143796,-0.02279023,-0.009115983,-0.01248224,0.07010739,-0.0024774363,-0.060974896,-0.0017181102,-0.06156076,-0.03121509,0.09153655,-0.052805807,0.07967226,-0.07748424,-0.03494351,-0.004334891,0.05104437,0.0117234485,0.030611755,0.08535776,0.0060466467,-0.02119445,0.053106148,-0.013621219,0.010578436,0.06820236,-0.014877324,0.041713268,0.034346316,0.02289772,0.047365863,0.021655468,0.008733753,0.020205377,0.061764974,0.040427882,-0.024064727,-0.063108,-0.085565574,0.038787458,0.020324746,0.07016169,0.0033910694,-0.012829739,-0.013481892,-0.035987422,0.03341027,-0.10118972,-0.10077495,0.030525716,-0.0048441645,0.06702803,0.04660825,-0.0017619871,-0.05003099,-0.0027440193,0.044480685,-0.010888899,-0.010110956,0.07694779,0.021185333,-0.04704246,-0.027884047,0.021849433,-0.025067074,0.00040566854,0.022361485,-0.0077508646,-0.09854894,0.011907741,-0.008264707,4.5500062e-33,-0.032559734,-0.023810962,0.04295874,0.038246717,0.0735858,0.017278831,-0.07264497,-0.016848903,-0.02106178,-0.05235677,-0.046979167,-0.037220277,0.04081552,-0.018092582,0.0016596458,-0.013382145,-0.023519872,-0.014307606,0.013500203,0.034634784,-0.050599705,0.110523626,-0.0035502692,0.009016116,0.0077775726,0.0028626905,0.0072256667,-0.08333042,0.00096190115,0.027562857,0.0269344,-0.057079937,-0.055700462,0.025488535,0.014400448,0.02859193,0.0016802995,-0.031391863,-0.0515887,0.026908934,0.033665933,0.03326249,-0.020783449,0.014811049,-0.032756668,-0.03366331,-0.048873093,0.091713555,0.03670717,0.05241083,0.058705717,-0.04687118,0.027241081,-0.017197449,-0.04596903,0.0023997303,-0.078819126,0.042142622,0.080291726,-0.0237262,-0.013234181,0.11254347,0.02575598,-0.013891569,0.013079264,-0.06726503,-0.10893437,-0.0057920227,0.0017283023,-0.0577345,0.015394397,0.0067205834,0.010814554,-0.020080915,0.026151543,-0.020167315,-0.00095938693,0.009656698,0.016180396,0.004447643,0.018154694,0.039126698,0.053111173,0.021394292,-0.05959341,-0.028790822,-0.027108245,0.043152455,-0.010807116,0.09347701,0.016654825,-0.057051904,-0.05226527,0.026567345,0.011683695,-4.4058825e-33,0.119999,-0.11893323,0.06402094,-0.049153224,-0.014341327,0.089401886,0.02212081,-0.0077739,-0.04363976,-0.069107905,0.104569875,0.079743914,0.051635537,0.011339012,0.082289286,-0.05525945,0.025042793,0.11161772,0.033506833,0.0051590013,-0.001803882,0.012379058,-0.058247168,0.035213094,0.018682951,0.054414075,0.0002587388,0.06717126,0.050293043,0.046602722,0.033070654,-0.0023094704,-0.03314459,0.023195472,-0.0066269045,0.09257181,0.0088156415,-0.022155903,0.0007907656,0.014272444,-0.045654364,0.03901399,-0.11982387,0.048615687,0.03487291,0.026707537,0.042564914,0.005936675,0.0146948695,-0.073577985,0.04669927,-0.020151686,-0.06900869,-0.0021392794,-0.0009360073,0.046082754,0.00595891,0.031549074,0.04326146,-0.04434443,-0.09267692,0.02398504,-0.039768737,-0.032348208,0.099420555,0.077314354,-0.0017103475,0.030416485,0.028134786,-0.08854685,0.053821098,-0.005682702,-0.00047405908,-0.0021555808,-0.003886944,-0.11364303,0.014513617,-0.082173936,-0.016449967,-0.053726494,0.012679748,-0.052507095,0.00802982,-0.061983787,0.0033214202,-0.09518796,0.04176805,-0.020218221,-0.020719916,-0.008122846,0.04749792,0.040226113,-0.10680394,0.057969976,0.19924855,-5.0549282e-08,0.09622971,-0.05632181,0.046042,-0.00020519712,-0.0071090814,0.016741263,0.08752637,-0.022009723,-0.011019949,-0.016666245,0.009513847,0.01754779,0.023991998,0.06151844,0.03372489,0.03860191,-0.04807849,0.073464185,-0.02221833,-0.03286185,-0.035563312,-0.04602697,0.014065248,-0.02976097,-0.02169973,-0.12728845,0.1002757,-0.004564251,0.021016615,-0.041814737,-0.007937754,0.0013919038,-0.012254754,0.01765538,-0.021545874,0.026137328,-0.093284495,0.043684658,-0.05332515,0.008689534,-0.0016891701,-0.03428268,-0.07463887,-0.011614818,-0.040423855,-0.056460395,-0.030829301,0.051459555,-0.027961632,-0.023927309,0.011615554,0.011587496,0.0376113,-0.06342633,-0.05217524,-0.007916239,0.0066287518,-0.015114546,0.034513313,-0.026696187,-0.08075859,0.08552638,0.14645916,0.035095956 +4.2.1.133,Requires Mg2+. The enzyme was characterized from the plant Cistus creticus subsp. creticus.,384,0.9999999,-0.08095553,-0.0207909,-0.04377939,0.0016726172,0.039503213,-0.0018594917,-0.041498445,0.04611183,-0.034051906,0.01758074,0.058358643,-0.07783458,0.037149053,-0.030394034,-0.047972515,-0.008396765,-0.0017328566,0.04360559,-0.003854717,-0.031557124,0.0862651,0.03599227,0.008905842,0.014528201,-0.0027261262,-0.006303077,0.017597046,0.02910594,0.07360766,0.012998504,-0.01954484,0.040709436,0.07152942,-0.06275559,0.03214722,0.07078049,-0.031895917,-0.068783686,0.030668072,-0.019388437,0.051583815,0.04317733,0.054236867,-0.019747311,-0.046178985,-0.10444833,0.06837789,-0.019818408,0.024509303,0.043435987,-0.032926176,-0.06738147,-0.10454565,0.042621408,-0.004722467,0.025197305,-0.09198744,0.02835877,-0.00024604012,0.0056426115,-0.025724456,0.0036113197,-0.020741673,-0.024994666,0.040485844,-0.010201107,-0.017562397,-0.056401297,0.059153,-0.021345552,0.0031633493,-0.05578905,-0.04089088,-0.021093588,-0.051593218,0.030784285,0.009905331,-0.08433901,0.024145115,-0.015372447,-0.041304056,0.040591877,0.08194627,0.029133275,0.04019166,0.035260145,0.04449355,0.06372159,0.018613918,0.02286936,0.11134309,0.05816953,-0.018620698,0.007895702,-0.052457623,0.07961217,-0.04666456,-0.026758479,0.0082185,-0.021717675,-0.009141165,0.06780663,-0.024931889,-0.013145612,-0.060770407,0.04010452,-0.075085014,0.04330969,-0.009183552,0.032355238,0.027670193,-0.0006788168,-0.0074506095,0.04428781,0.06367015,0.077859886,-0.031079672,-0.07361952,0.024361331,-0.007354517,0.017353721,0.008406851,-0.02471042,-0.010683224,-0.037161212,0.049661696,-0.080047235,2.5534887e-34,-0.060101688,0.036221143,0.02877792,0.0023047319,-0.07918725,0.011883909,-0.08108345,0.018508185,-0.058464967,-0.07965937,-0.13351212,-0.09431675,0.00093808374,-0.015276578,-0.03038024,-0.043451816,0.007983017,-0.019267982,0.082163304,0.024435598,-0.018431425,0.062737614,-0.01560353,-0.016185204,0.022131773,0.09081105,0.06316483,-0.036236998,0.10430949,-0.0145186875,0.08020457,-0.09413978,-0.036966212,0.051666047,0.055076104,0.04980733,-0.004028433,-0.039059572,-0.048283257,0.08470121,-0.020074528,0.027206112,0.0082039805,-0.008359213,0.11123417,-0.099076,-0.040813163,0.04108695,0.04201604,0.05738748,0.029108157,0.056939103,0.07174385,0.0470298,-0.11531497,0.04958071,-0.008920025,0.06460957,0.0648875,0.013764276,-0.004575897,0.0038685799,0.04607737,0.06236145,0.114295214,0.042462043,-0.17440015,-0.08110843,-0.026354436,0.077591285,-0.039164063,-0.10144442,0.029458255,-0.013129557,0.06526005,-0.02991722,-0.008376734,0.021369608,-0.052615277,0.051619846,-0.051375683,-0.01435385,0.011381764,-0.033445235,-0.053073984,-0.08022324,-0.026733328,0.017817501,0.033916313,0.024185322,0.09532633,-0.032895677,-0.0650508,0.06365751,-0.012221907,-3.472907e-34,0.044091705,-0.020176124,0.09212474,-0.012783533,-0.09275094,0.06689921,0.024561465,-0.118772104,0.01388771,0.021073787,0.10173505,0.029875234,-0.034351304,-0.053355694,0.002136825,0.002032143,-0.0040682787,0.107884526,-0.014774496,0.021917274,-0.03160149,0.10994085,-0.006147411,0.029675435,0.034895074,0.032111365,0.05696039,0.04677804,0.056577407,0.040946748,0.04213141,0.04236687,-0.07956116,0.008744638,-0.056313362,0.0041192505,-0.018935371,-0.035601873,-0.01755504,0.10391349,0.027961828,0.0663553,0.07973304,0.084050864,0.011540577,0.017490465,0.005931026,0.049824934,-0.034178555,-0.039505288,-0.02959501,0.009140838,-0.06006211,-0.032314412,0.084709615,-0.030989299,-0.029573806,0.021774868,0.039165907,-0.038310006,0.017097864,-0.038064197,0.013064227,-0.06427056,0.037259713,0.05971888,0.028607525,0.03046732,0.011446067,0.06477197,0.03473385,0.054290745,0.050701834,-0.020115154,-0.035791956,0.07861247,-0.059026603,-0.031130638,-0.018270839,-0.07516643,0.011024931,-0.00012833042,0.008102867,-0.030381467,-0.021752281,-0.13030632,-0.05005973,0.09671674,0.06837916,-0.019879855,-0.046622805,-0.087578066,-0.025348468,-0.011316286,0.11436374,-2.4495593e-08,-0.049781546,-0.064512506,0.04501089,-0.07817068,0.034359016,0.030353902,-0.05814325,-0.06990102,0.061755896,0.010216705,-0.041925468,-0.08124018,0.010479442,-0.00972063,-0.027739108,0.018296912,0.051586125,0.06390588,-0.028527757,-0.010117962,-0.07039982,-0.04343321,-0.10935054,0.046663016,0.00136743,-0.074839815,-0.012647205,0.07124218,-0.026750453,0.004368406,0.028605416,0.010611335,0.038128022,-0.04406492,-0.08794668,0.04170764,-0.0010541665,0.00810967,-0.038891405,-0.09096333,0.027103236,-0.039003856,0.01640907,-0.04908038,-0.012202159,0.005407691,0.038566824,0.035631392,-0.041979723,0.018642679,0.018078791,-0.032246526,-0.017220456,-0.060409747,-0.06178933,-0.029397573,0.028794255,-0.08432688,-0.061306227,-0.08301733,-0.010391444,0.05080488,0.08532585,-0.069790505 +4.2.3.124,"Requires Co2+ [2]. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Requires an NAD+ cofactor, which is transiently reduced during the reaction [1,4]. The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex [6,7].",384,0.99999994,-0.020329464,-0.03426171,-0.07303612,-0.050657358,0.0030378737,0.03467497,-0.14428176,0.04162214,0.11749956,-0.0004978248,0.0039816597,-0.02227006,0.09950321,0.086184375,-0.04153837,-0.029225124,-0.09258168,0.008446532,0.008867189,-0.040574364,0.022029392,0.12166973,0.010602239,-0.024918607,-0.015388087,0.016198644,0.037751306,-0.03537512,-0.013468798,-0.048447035,0.008849314,-0.008347053,-0.007376177,-0.06580111,0.049424604,0.0713838,-0.042929787,0.015625458,0.1857024,0.027957475,-0.041377407,-0.008049791,-0.012487653,0.00901207,-0.011766798,-0.011259012,0.06796615,0.042415056,0.058941495,0.010383473,-0.0926319,0.0343465,-0.017178828,-0.010904645,0.10211071,0.036737725,-0.03726261,-0.056793656,0.02180151,-0.07363069,0.030512085,-0.10012021,0.07684651,-0.010843977,-0.051504616,0.016796786,0.08385843,-0.08472112,0.007134691,-0.028611114,-0.12272066,-0.02252656,0.04480881,-0.0066497824,0.022676079,-0.004684762,-0.087707534,-0.027600689,-0.022187354,-0.0057734447,0.058707416,-0.023622468,-0.008204763,0.057942264,0.06770218,-0.023810998,0.095693514,-0.018702934,0.03386445,0.034951277,0.02765471,-0.01555792,0.02866593,-0.031456806,-0.095875815,-0.040492527,-0.0113804,0.03040489,-0.012033844,-0.06770096,0.005528346,0.03711797,-0.015365158,-0.032275036,-0.04084845,-0.008025358,0.069835365,0.12912843,-0.021136785,-0.0039714817,-6.165359e-05,0.016788572,-0.029744187,-0.06418911,-0.032284588,0.13103795,0.087890536,-0.034455672,-0.08116384,-0.006317543,0.059519444,-0.012543845,0.0077914945,0.027142098,-0.08870733,-0.0015244627,-0.07178917,2.9772278e-33,0.0107372105,0.111055054,0.0043908637,0.0028706354,0.043548778,-0.027461182,-0.12235622,-0.032847628,-0.005224721,-0.09207886,-0.048340194,-0.06600666,-0.011368486,0.05334477,-0.033087455,0.003938698,-0.017029531,-0.037014943,0.0025451602,-0.010020741,0.06450238,0.07052223,-0.010390481,0.07789357,0.007239849,0.10912721,0.042083323,0.07975801,0.03659107,-0.036544897,0.01607521,-0.08096312,-0.07533441,-0.002012875,0.0681769,-0.011292679,-0.045137577,-0.0058526993,0.05184371,0.054738995,-0.085668966,0.03979007,-0.061844137,-0.032314837,0.10085153,-0.0660777,0.009611386,0.1167265,-0.05145086,0.0659073,0.06104523,-0.025352394,0.0840183,-0.048095915,-0.062064823,0.016533067,0.0013228704,-0.01031738,-0.016736764,0.06873515,0.03874697,-0.026111454,0.010198049,0.041194618,0.0050323103,0.045831513,-0.06532556,-0.043153625,0.03955125,0.033220142,-0.0161041,0.058350228,0.012457537,0.07246512,0.034387425,-0.0093621155,-0.07492297,-0.03637889,0.022985464,0.01780619,-0.008468674,0.015324396,-0.012241292,-0.018898863,0.02632315,-0.011732979,-0.029380972,-0.041674603,-0.01766543,0.05126081,-0.0142603265,-0.06353389,-0.0435962,0.025321644,0.0026793778,-4.2286925e-33,0.13852441,-0.08130812,0.10710658,-0.083765425,-0.07326965,0.09701911,0.014159323,-0.11531164,0.047169827,-0.04278248,0.03382333,0.027266664,-0.00242109,-0.01090516,-0.009313997,0.005146811,0.017122803,0.052544598,-0.03455402,-0.027811954,0.048669606,0.015693795,-0.0050373944,-0.026369272,-0.0026127808,0.07994743,-0.037512075,0.052749105,0.04498404,0.053044315,-0.040224228,-0.045120537,-0.054255422,-0.075047486,-0.01977701,0.06921802,-0.08533026,0.01949836,-0.052086733,-0.020421652,0.016379913,0.022180464,-0.05863866,0.033489835,0.022243962,-0.017563593,-0.02170223,-0.018504193,-0.008136098,-0.05798183,0.03553753,0.052669745,-0.00944107,-0.05546658,0.04820118,0.013157033,0.02977677,0.008632709,0.06707723,-0.04374534,-0.06932776,-0.06437025,0.008724478,0.021100026,0.0511696,0.00464522,0.018719306,0.037425976,0.04424899,-0.03526812,0.046221133,0.03263344,0.02869736,0.018420905,-0.009570976,-0.0076210597,-0.08247114,-0.034082185,-0.015625825,0.018513044,-0.031035079,-0.06948307,-0.014260304,-0.08978966,-0.019989055,-0.018335193,0.0686214,0.030729687,0.022241551,0.009898027,-0.00039733955,0.07474916,0.004159917,-0.0009397118,-0.010866203,-4.6369824e-08,0.07303548,-0.008575013,0.0070974985,-0.040575583,0.031444434,0.03063308,-0.04140873,-0.07690797,0.0027839015,-0.016307216,-0.004574076,0.07654703,0.05342442,0.010818341,-0.023974417,0.028600035,-0.07319124,-0.038773924,0.011908754,-0.042324897,-0.10244873,-0.031919513,-0.1231507,0.061963845,0.08840545,-0.065783724,0.039037984,-0.017846823,-0.015119396,-0.03458001,0.043671478,-0.0116591295,-0.011633427,-0.094291896,-0.09151083,-0.038386114,-0.023203898,0.007148682,0.049251672,0.016689433,0.020577725,0.0035127746,-0.07467729,0.028749518,0.01597546,0.06983056,-0.015452144,0.0009985166,-0.07471646,0.015959257,0.014491392,0.0051819254,-0.014477151,0.0087446,-0.10887217,0.052618735,0.018913897,-0.04233675,-0.008949286,-0.07209103,-0.0007499102,-0.021038515,0.12957741,-0.06225589 +4.2.3.125,"The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and gamma-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.126, gamma-muurolene synthase. +",384,1.0,-0.08777033,-0.047650225,-0.08891585,-0.038306326,0.05195122,0.028525766,-0.008078845,0.059926175,0.064910285,-0.031093355,0.08557323,-0.05688885,-0.043793406,0.021258993,-0.11471208,0.015435614,-0.007922219,-0.01595803,0.032900933,-0.06203892,0.04189901,0.044470325,0.05552172,0.05523717,0.027002115,-0.050189108,0.028760001,-0.03417307,-0.020774813,-0.07854673,-0.009931098,-0.0415141,-0.027350469,0.017465191,0.01927476,0.012763434,-0.06311028,-0.07055847,0.053516194,0.05710157,0.019380912,0.0019448791,-0.022985404,-0.010553543,-0.1004646,-0.032384355,-0.03398115,-0.014884021,-0.0013822147,-0.025606595,-0.029228106,-0.06856749,0.0066515566,-0.07293472,0.0646635,0.033726852,-0.07449495,-0.09911079,0.00725158,0.10154711,0.009313129,0.0783223,-0.02567074,-0.03292325,-0.0074846656,0.03917328,0.042005464,-0.051952425,0.0143717835,-0.046624903,-0.09282127,-0.076441444,-0.04627535,0.0065588774,-0.042954262,0.0822488,-0.004760132,0.0031703375,0.040358253,-0.04782047,-0.03332138,0.07182165,0.002449395,0.042968534,0.073954135,0.027371323,0.039082807,0.101142645,0.033032678,-0.0060931216,0.07234908,0.031931546,-0.027559575,-0.028049674,-0.04534616,0.10269143,0.00041140872,0.01177255,0.08535749,-0.036540486,0.039292052,0.049527645,0.030891946,-0.06961016,-0.10093093,-0.014625304,0.043280404,0.062949136,0.085826136,-0.015502406,-0.005569918,-0.0029623439,-0.008714522,0.00057126797,0.013060587,0.05637423,0.029385438,0.0033279755,0.022570556,-0.0059759268,-0.0029172038,0.01384576,-0.063557036,0.02553273,-0.015698176,0.084138535,-0.07822885,7.8695e-34,0.05608876,0.03760071,0.012734801,0.065409325,0.015136389,0.078254834,-0.07972823,0.070665546,-0.041812547,-0.062989414,-0.08877766,-0.10273094,-0.093326725,0.06425805,-0.05311355,-0.0036719644,0.018747346,-0.033888657,0.022436848,-0.023578446,0.0023468472,0.09736462,-0.02827911,0.008573941,0.08511363,-0.0005588031,-0.10223664,0.04044495,0.08490693,-0.024349717,0.010058247,-0.026236938,-0.056281786,0.03900223,-0.0076682717,0.024579836,-0.014328841,-0.0024612108,-0.010926362,0.0670363,0.01655977,0.023338782,-0.011764144,-0.031912066,0.052339453,-0.014348709,-0.04128906,0.03770992,0.06757837,-0.029819466,0.0056846943,0.021312784,0.105073735,-0.028675526,-0.043829296,0.05264055,-0.021494363,0.024877947,0.039054174,0.022074211,0.021435581,0.120193556,-0.029862417,-0.011159829,0.05452537,0.073482245,-0.10112001,-0.0112145115,0.002619156,0.06640859,-0.03842477,-0.024088556,0.0052777883,0.009814433,0.0739423,-0.05037942,-0.1368379,-0.08031044,-0.0108923465,-0.023497703,-0.07814375,0.006146728,0.035778917,-0.057880897,-0.024004616,-0.02392469,-0.044025227,0.02340321,0.03929288,0.041903965,0.020097125,-0.055729903,-0.07087845,0.032658756,-0.0024049738,-1.7978666e-33,0.049036615,-0.10104895,0.034352355,-0.014615113,-0.030537909,0.10398844,-0.053585954,-0.05752332,-0.019073645,-0.045107108,0.1060809,-0.008188626,0.020971874,-0.08930551,0.012435997,0.008413863,-0.05200157,0.11053565,0.018602151,0.008392032,-0.043786757,0.04409565,0.02227783,-0.016911954,0.09580145,0.022778274,0.03334816,0.059032883,0.067118794,-0.026499147,-0.05888314,0.007406969,-0.020083327,-0.055121537,-0.051709812,-0.040361688,0.019746056,0.025828023,0.019011633,0.011467212,-0.041388415,-0.00026560665,0.078449145,0.10670489,0.06922543,0.101047106,-0.014462078,-0.06260398,-0.034850843,-0.018844223,0.023123525,0.0039229137,0.015153333,-0.00096073345,0.005075876,0.015680406,-0.0050882488,-0.021161005,0.039622374,-0.037867643,-0.062490474,-0.011293799,-0.033163305,0.018957675,0.07108687,0.06690232,-0.028153252,0.114718184,0.03954334,-0.08930249,0.075519815,-0.040693015,-0.01958322,0.036224864,-0.017409844,0.0066249366,-0.0318501,0.033672124,0.04285213,-0.05687398,0.044559084,0.0027846312,-0.010296339,-0.079987116,-0.03253443,6.8739966e-05,0.068372175,0.05875873,0.03414419,0.018852768,-0.008881075,0.06714012,-0.054907613,0.003586483,0.0940398,-3.5700506e-08,0.03831399,-0.0065157255,0.017212976,-0.07460678,0.025934039,-0.014234482,0.06673106,0.030526148,0.02559466,0.0309353,-0.06854203,0.042784855,-0.0025439835,0.029761491,0.017339597,-0.0032022826,-0.026392365,0.036147013,0.011169455,0.051722534,-0.05118996,-0.00037389837,-0.10080607,0.05176958,-0.06959989,-0.115497254,-0.0004093927,0.057992723,0.01689252,0.031537797,-0.040236965,0.046434734,0.013143313,-0.07001773,-0.071020484,0.022947831,-0.022115044,-0.11337776,-0.0068088896,-0.0154529475,0.02587549,-0.09196973,-0.05018512,-0.04189944,-0.009690645,-0.05064992,0.023573935,0.031447794,-0.0036351318,0.04344712,0.063081905,-0.008823142,-0.0016153683,-0.04262528,-0.07064039,-0.07898564,0.048825085,-0.051008966,-0.056385115,-0.11563324,-0.036890853,-0.026153775,0.17590874,0.02786683 +4.2.3.126,"The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and alpha-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.125, alpha-muurolene synthase.",384,1.0,-0.06679881,-0.049422234,-0.0926087,-0.035514392,0.07370622,0.027447307,-0.030065576,0.046396583,0.06461644,-0.028900165,0.059354644,-0.052120753,-0.07862733,0.026482206,-0.11825028,0.01388027,-0.04439558,0.0036199426,0.036317404,-0.050416883,0.048050247,0.034943786,0.04265513,0.07244931,0.022067817,-0.044709142,0.025101874,-0.0207854,-0.010390613,-0.08520461,-0.0020885882,-0.036036886,0.029700188,0.0062546004,0.011679369,0.0035956153,-0.08116604,-0.07064202,0.058254927,0.074093424,0.042019494,0.0034538913,-0.028756019,-0.0020555,-0.11703566,-0.023104686,-0.033443324,0.0029483794,-0.009542397,0.0054353075,-0.019723324,-0.08053315,0.0004890385,-0.08344282,0.04348445,0.021147022,-0.057322398,-0.06924478,-0.00283428,0.10264858,0.021135502,0.08201407,-0.022688635,-0.015197124,-0.016687915,0.047059864,0.05959571,-0.056908973,0.015665252,-0.061058342,-0.07992545,-0.08623006,-0.016101941,0.008329715,-0.03777763,0.078323506,0.0035061645,0.004142487,0.03012823,-0.024126112,-0.01534846,0.06987653,-0.018184466,0.042000942,0.06609579,0.04001733,-0.0071102316,0.056434818,0.008647121,-0.008563514,0.08968267,0.025638571,-0.041688528,-0.042046953,-0.017698212,0.107139334,-0.010413925,0.0078047756,0.059370376,-0.043331847,0.02463952,0.057584845,0.011205827,-0.09385907,-0.10228589,-0.01740472,0.05690096,0.03787194,0.0681862,0.00887198,-0.021736866,-2.7218382e-05,0.005564855,-0.013553059,0.027700009,0.042783916,0.018062413,0.017375203,0.03538235,0.0037379912,0.0003285596,-0.0010306727,-0.037251104,0.040140044,-0.035140578,0.07473931,-0.066771574,7.2824194e-34,0.06285142,0.026995689,-0.003959007,0.07395381,0.007642908,0.049906507,-0.068311,0.068361506,-0.06468632,-0.07496597,-0.07216124,-0.0949274,-0.081744224,0.054812096,-0.03907671,-0.0141173005,0.02540634,-0.04900094,0.025978016,-0.018575655,0.017849889,0.08836854,-0.02654652,0.030324414,0.084629275,-0.007307177,-0.09744009,0.038040135,0.07708188,-0.035823423,-0.0011710577,-0.023956966,-0.075834274,0.040637113,-0.017472735,0.010229167,-0.017567627,-0.012112186,-0.025852675,0.07136688,0.0064130346,0.020876205,0.020467633,-0.0338126,0.08969929,-0.01682608,-0.05647931,0.050407425,0.075038984,-0.023380011,0.021154769,0.02558801,0.10124675,-0.026276987,-0.053418797,0.02652101,-0.03838423,0.030384064,0.028861213,0.034319717,0.040519003,0.13070585,-0.02169026,-0.028740779,0.029135182,0.0900951,-0.102782376,-0.011399565,0.014953421,0.07564523,-0.0171979,-0.032887716,-0.0055949744,0.018780148,0.06342704,-0.032113038,-0.13624066,-0.06817355,0.008607223,-0.044615064,-0.074840814,0.009587265,0.041939788,-0.036409866,-0.036549293,-0.04466847,-0.038141917,0.03919744,0.02781083,0.03204362,0.011516988,-0.06966308,-0.0881774,0.055587143,0.008492861,-1.7762693e-33,0.062822424,-0.11531642,0.045453828,-0.011888285,-0.053582042,0.109605946,-0.044994388,-0.049329095,-0.01894893,-0.026297648,0.095796436,-0.04030453,0.019909438,-0.100000955,0.038233157,0.0029672636,-0.04245172,0.09157011,0.028629836,0.0067752665,-0.027304634,0.04863938,0.021740556,-0.021565637,0.1081621,0.0118324775,0.039588623,0.08824607,0.056021105,-0.032148287,-0.044407953,0.007837905,-0.010959411,-0.042337894,-0.06699684,-0.017207261,0.019261844,0.015895661,-0.008476111,-0.016827006,-0.03396744,-0.015612433,0.07223214,0.11736851,0.08760761,0.06670661,-0.020108536,-0.055655006,-0.009415678,-0.008573898,0.02762453,-0.0011981378,0.022415819,0.00038393014,-0.0038453732,0.020028759,0.005083758,-0.0131697105,0.03228647,-0.047482207,-0.051696423,-0.0026165787,-0.038289346,0.03502769,0.055345718,0.049323186,-0.009515256,0.12057998,0.045570508,-0.06681609,0.071236596,-0.015417813,-0.007923437,0.047157004,-0.033535488,0.006948686,-0.017292138,0.008369631,0.055185743,-0.04257948,0.01882348,-0.0014237659,-0.003589285,-0.042541113,-0.029346336,-0.0009228088,0.0913771,0.046812933,0.038812365,0.033224758,0.011536238,0.054266717,-0.07695748,-0.0178557,0.08606719,-3.6949576e-08,0.05023438,-0.015222039,0.024288738,-0.07833024,0.030108692,-0.021692405,0.053427305,0.0010338848,0.00056319375,0.020816391,-0.07952961,0.022740588,-8.182297e-05,0.02732161,0.050883614,-0.019936902,-0.028684212,0.028976656,0.0034947838,0.041099217,-0.0457866,0.0065623703,-0.1179221,0.04343949,-0.06299308,-0.1113869,-0.0124996845,0.05531688,0.012729267,0.06100534,-0.044404157,0.023044111,0.028755061,-0.077487476,-0.04255326,0.049689133,-0.020057807,-0.124866635,-0.04525502,-0.020542607,0.027198618,-0.1076594,-0.033721562,-0.048876528,-0.005257842,-0.069708265,0.025731917,0.021158557,0.014903736,0.019678107,0.087994255,-0.015463759,0.00087915076,-0.017408153,-0.07199035,-0.09207602,0.028961992,-0.053239997,-0.046107467,-0.105532385,-0.037434913,-0.024554208,0.1804995,0.031136045 +4.2.3.127,"Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-cubebene, (+)-sativene and traces of several other sequiterpenoids [1-3]. beta-Copaene is formed in the presence of Mg2+ but not Mn2+ [2]. See EC 4.2.3.13, (+)-delta-cadinene synthase, EC 4.2.3.128, beta-cubebene synthase, and EC 4.2.3.129, (+)-sativene synthase.",384,1.0,-0.07268098,-0.09371312,-0.11122831,0.027978973,0.029894229,0.03496238,-0.04136875,0.040432706,0.032246087,-0.019307896,0.06437685,-0.010675305,0.008336725,-0.04223276,-0.07028722,-0.028396277,-0.006335589,0.024772977,0.023591122,-0.038625117,0.04218469,0.056721397,-0.039353535,0.00830935,0.09386964,0.033921603,0.014753587,-0.06218354,0.05439822,-0.049176067,-0.010915442,0.046646394,0.0207158,-0.025447294,0.078012735,-0.00797281,-0.06509122,-0.008435609,0.013126057,0.0012373182,0.014641536,0.011678492,0.06661106,-0.09467125,-0.05853003,-0.06038287,-0.027881788,0.0070173587,0.03959549,0.0032660689,-0.05500432,-0.06465495,-0.027677529,0.057171047,0.04055849,-0.021675356,-0.042035554,-0.04810378,0.019581944,0.04746998,0.023237336,0.045001924,-0.021478035,-0.023125684,-0.039816514,0.030300092,-0.031284,-0.0034155815,0.07352715,-0.008031868,-0.04241085,-0.031193228,-0.008015602,-0.039984167,-0.02057909,0.08809769,0.008827183,-0.05630937,0.066857405,-0.028637808,-0.019704891,0.0630051,0.066933535,0.037833482,0.0069102296,0.06236019,0.041929256,0.05854414,0.022210376,-0.024704617,0.11423745,0.13013425,-0.03192871,0.013295366,-0.0959769,0.035114244,0.031413443,0.10764195,0.035985574,-0.014294272,0.06476173,0.0741223,-0.036177598,-0.103559636,-0.03746189,0.04666879,0.04008299,0.0017579858,0.09631541,0.028214272,-0.0031891554,0.018468486,-0.007870646,-0.0047904924,0.0058458555,0.060439695,0.012860164,-0.07433527,0.037235767,-0.03987711,0.018865796,0.02187169,-0.043655805,-0.014634225,-0.0032157097,0.04181205,-0.035145964,9.620387e-36,0.047840755,0.08326566,0.08057793,0.055155482,0.028884321,0.007237272,-0.057907894,0.0465466,-0.034834735,-0.09107527,-0.11970389,-0.098226644,-0.10423444,0.08337523,0.02794699,-0.05774085,0.028367557,-0.06837783,0.117828704,-0.0011744095,0.010093731,0.06958057,-0.0711114,0.016956765,0.043969616,0.0028435343,0.019565513,0.032684013,0.0662054,-0.022348473,0.009060986,-0.09048783,-0.06473342,0.012337033,0.04700708,0.014554475,-0.0129768485,-0.0026174593,-0.11898475,0.04737289,0.03632893,0.024575539,-0.035558008,-0.010591272,0.050956234,-0.05854135,-0.052028105,-0.0010235361,0.080835454,-0.028943663,-0.034672625,0.08351819,0.09387648,-0.017082714,-0.06604955,0.036481358,-0.027730716,0.021227347,0.060303714,0.030696739,-0.0015135243,0.042604383,-0.02196408,0.033192143,0.0115059465,0.12021104,-0.10739341,-0.051086083,-0.0077362903,-0.014513287,-0.029361267,-0.015992735,-0.022726294,-0.06620394,0.100257754,-0.052304514,-0.06364525,-0.053258993,0.0043664295,-0.050492074,-0.07812646,-0.02784625,0.0133719025,0.037437905,-0.08777311,-0.044139802,-0.023224369,0.049523965,0.01776474,0.023524215,0.02917004,-0.051150434,-0.07582211,0.047194503,-0.015559847,-1.0453503e-33,0.010304181,-0.06158245,0.07548308,-0.08078264,-0.10001577,0.103112936,-0.009594717,-0.073915504,0.016999915,-0.039400384,0.055502843,0.004897855,0.06625974,-0.10255344,-0.041599765,0.012208738,0.034007117,0.11406112,-0.010802093,0.040251788,0.005630874,0.04798081,0.06156272,0.019313272,0.017625589,0.018874636,0.087104574,0.049029496,0.030730255,0.061991204,0.06528139,0.036910698,-0.034684524,-0.03189637,-0.1287127,0.0045695654,-0.062459826,-0.029391007,0.011106437,0.060607456,-0.018690834,-0.03343065,-0.0020137345,0.13136873,0.12380954,-0.030714309,-0.03611806,0.012166128,-0.034076486,-0.05974661,0.035278726,-0.0018204231,-0.025577227,-0.036252674,0.09121864,-0.011426746,-0.009725022,0.0079456745,0.0857324,-0.07934101,-0.028673507,0.0056578456,-0.09875102,-0.040661544,0.078885034,0.056289017,-0.00048202672,0.054381125,0.048021007,-0.04445076,0.09456245,0.040034257,-0.0008648288,0.028835857,0.008891155,-0.02056966,-0.0074408078,-0.029109541,-0.013839476,-0.014400864,-0.017194023,-0.034659196,0.0610558,-0.08440481,-0.06347889,-0.060965206,0.07218187,0.043396685,-0.017968435,0.0523016,-0.04276369,0.035749856,-0.1012994,0.04630085,0.061071128,-4.0593765e-08,0.06780253,-0.022808684,0.010678012,-0.059011936,-0.03436122,-0.02532513,0.06700909,-0.038422707,0.031949185,0.07127573,-0.07108199,-0.024976313,0.023569252,0.015809665,0.028595185,0.003240263,0.013466142,0.008835572,-0.022083225,0.0090596005,-0.039760865,0.017489716,-0.051353935,0.03230662,-0.03914996,-0.07085776,0.012018517,-0.029410899,0.03433381,0.03657544,-0.011817384,0.04937404,-0.000456602,-0.08604418,-0.012177408,0.06505624,-0.008693494,-0.029262822,0.013498595,0.0009480443,-0.046498872,-0.06586263,-0.012038772,-0.023770511,-0.022050476,-0.050278682,0.03984235,0.02376135,0.02255499,-0.029145097,0.036398094,-0.041643944,-0.02269485,-0.090675846,-0.05622377,-0.027665641,-0.010515033,-0.00751979,-0.07455246,-0.08704419,-0.052402306,-0.048698165,0.07702779,0.031775206 +4.2.3.128,"Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-copaene, (+)-sativene and traces of several other sequiterpenoids [2-4]. It is found in many higher plants such as Magnolia grandiflora (Southern Magnolia) together with germacrene A [1]. See EC 4.2.3.13, (+)-delta-cadinene synthase, EC 4.2.3.127, beta-copaene synthase, EC 4.2.3.129, (+)-sativene synthase, and EC 4.2.3.23, germacrene A synthase. ",384,1.0,-0.057220887,-0.07150639,-0.069373064,0.00574628,0.016803676,0.041110694,-0.047005374,0.041555155,0.08139985,-0.013580151,0.06946297,-0.011974282,-0.03157286,-0.013775486,-0.08546706,-0.03479135,-0.027911456,0.04701531,0.036630336,-0.028015295,0.03859068,0.0499118,-0.054102264,0.080490105,0.08177912,-0.020311864,-0.030674068,-0.06598351,0.011658949,-0.051791716,-0.03309696,0.020740634,-0.0041739885,0.035046473,0.005917376,-0.03295146,-0.060532145,-0.027380152,0.040689208,-0.012472234,0.028213538,0.00077340676,0.02091597,-0.06720481,-0.09806461,-0.047232635,-0.08467065,-0.0035622935,0.027062967,0.0059732893,-0.05751297,-0.046899486,-0.04803242,-0.0075704455,0.027743088,-0.038742382,0.030810142,-0.046772152,0.04063638,0.116328314,0.058486182,0.055851504,-0.021592552,-0.04350458,-0.044329394,0.0046222233,-0.016359476,0.032158937,0.08653867,-0.019292124,-0.07565479,-0.058116205,0.007471639,-0.025744287,-0.019803287,0.08875725,-0.0064020716,0.011850988,0.07394513,-0.060051627,0.034781415,0.088267155,0.025757214,0.07886957,0.044661436,0.0023519949,0.019696228,0.06145618,0.072031386,-0.07318183,0.10116846,0.051907122,-0.09268742,-0.024364322,-0.09346964,0.077735595,-0.011327163,0.008220911,0.040946133,-0.04993605,0.057847977,0.08183764,-0.00207826,-0.08406254,-0.07698452,0.04578988,-0.0027418025,0.029601194,0.08722962,-0.005536387,-0.024404677,0.019350767,-0.008008933,-0.020359978,-0.04183444,0.08070498,-0.018520767,-0.098402016,-0.0004892292,-0.041911334,-0.012041607,0.015404556,-0.0025841426,0.0063240696,0.057111286,0.042463526,-0.051076,-2.4734465e-34,0.086195596,0.08835715,0.06937162,0.08234606,0.028441738,0.008233784,-0.055109415,0.066357225,-0.094935544,-0.07955964,-0.091743045,-0.12129116,-0.08898802,0.06706652,0.023641298,-0.006346244,0.026522378,-0.09290783,0.07020509,-0.023496544,0.007614807,0.070799276,-0.07071592,0.010960488,0.03500658,0.020837218,-0.045014225,0.040347062,0.041274093,-0.015412211,0.0012377268,-0.07809735,-0.059709635,0.041482568,0.036034364,0.019359712,-0.02676792,-0.017607972,-0.061272144,0.057038862,0.027937042,0.07087539,0.03081465,-0.005327251,0.07834914,-0.017157502,-0.064194314,0.03383066,0.085681014,-0.010658013,-0.02087651,0.022925125,0.07271669,-0.0063778623,-0.07995557,0.064792916,-0.012910777,0.0017216179,0.10158278,0.040598456,0.045383677,0.04472094,-0.07905674,-0.024544755,0.029018698,0.13862175,-0.095203705,-0.009524195,0.01013772,0.052516162,-0.006959269,-0.045598555,-0.029787825,0.0011217601,0.088472754,-0.005346015,-0.051276434,-0.041736044,0.0040448625,-0.03948683,-0.06679805,-0.014386795,-0.0024917307,0.07111387,-0.056011926,-0.11699724,-0.03958387,0.056150492,-0.03147629,0.035443272,0.035478998,-0.0068525923,-0.043489054,0.022880085,-0.030458152,-1.0252007e-33,0.03931254,-0.0747091,0.07817977,-0.065688185,-0.060610387,0.10284772,-0.047147032,-0.049411986,-0.0048380652,0.0041190074,0.048212647,-0.008563239,0.088732906,-0.050543167,-0.017707823,0.036815125,0.005188502,0.10095611,-0.017950643,0.058285113,-0.013076429,0.080398686,0.043487184,0.013095768,0.05475903,-0.022010213,0.05559333,0.045421403,-0.0026762073,0.009960732,0.029243164,0.0071325437,-0.053199675,-0.039818585,-0.10692215,-0.042453963,-0.032758217,-0.016375367,-0.010078052,0.035696022,-0.04446761,-0.040987566,0.028326167,0.1307218,0.11956063,-0.01981561,-0.047564704,-0.0078510875,-0.06289529,-0.009318083,0.021565583,-0.035491265,-0.00057664904,0.005736215,0.025706045,-0.014170787,0.038585775,0.002550653,0.04796928,-0.04725185,-0.013019953,0.052595418,-0.10265472,-0.04852803,0.06099452,0.023053614,-0.034321573,0.05790298,0.024879834,-0.048314173,0.08948468,0.020868706,-0.009833614,0.0056225946,0.019183725,0.011138971,-0.02227424,-0.039026327,-0.026411979,-0.022091884,-0.01056236,-0.023842193,0.053259555,-0.07317038,-0.06015326,-0.023474302,0.05474143,0.06919777,0.015955452,0.06065701,-0.06051157,0.043603644,-0.058552247,0.029334117,0.080002286,-4.0336243e-08,0.014156782,-0.006527874,-0.00499845,-0.10101127,-0.024362704,-0.019878779,0.05020859,0.009829968,0.0028465006,0.06257233,-0.059734628,-0.0075113163,0.008447336,0.0048795096,0.0011693051,-0.018549798,0.03846503,0.011232606,-0.04440862,0.055151507,-0.030385775,0.03619174,-0.07470664,-0.0075020203,-0.02591361,-0.13083556,0.033249445,-0.030409817,0.008799231,-0.01938792,-0.009900293,0.06485324,0.003042446,-0.068761446,-0.03323136,0.05868992,0.041113768,-0.05250631,0.01914366,0.008023867,0.0054978845,-0.07423816,-0.046952866,-0.02677289,0.009926846,-0.010102696,0.069378115,0.0029437242,0.052615415,0.043366488,0.025638368,-0.014508031,-0.011510635,-0.08784205,-0.07171086,-0.059082787,0.0062655653,-0.011494321,0.01365105,-0.0991632,-0.011669213,-0.061405487,0.14361541,0.053393412 +4.2.3.129,"Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-copaene, beta-cubebene, and traces of several other sequiterpenoids. See EC 4.2.3.13, (+)-delta-cadinene synthase, EC 4.2.3.127, beta-copaene synthase, and EC 4.2.3.128, beta-cubebene synthase.",384,1.0,-0.060694516,-0.06635057,-0.12201814,0.00026098717,0.01589337,0.042993885,-0.0390547,0.03832713,0.07208082,-0.043442044,0.08211645,-0.043939468,-0.07043676,-0.025559826,-0.064160936,-0.026162026,0.014384997,0.011893571,0.01795004,-0.064802855,0.015443461,0.06749381,-0.023137864,0.04632945,0.056359805,-0.0086413175,0.00088370685,-0.049324058,0.05497821,-0.08021455,-0.01566217,0.026858492,-0.00083130953,-0.0078810705,0.059596945,-0.009663619,-0.061079584,-0.010232492,0.05545652,0.050844345,0.00866506,0.021062836,0.041546013,-0.082920924,-0.09159295,-0.05050667,-0.05797298,0.03208465,0.06098774,-0.02631659,-0.024356231,-0.07102911,-0.016272662,0.036437716,0.030170886,-0.019383337,0.015596769,-0.08092018,0.021436878,0.06497344,0.018269436,0.06789792,-0.0033028014,0.004297093,-0.08447917,0.013798258,-0.018433081,0.019309517,0.06607797,-0.012363627,-0.076984316,-0.057458077,-0.0258077,-0.018541275,-0.01685432,0.08950453,-0.021581749,-0.050737124,0.048229713,-0.043698773,-0.0023649787,0.052496564,0.037275203,0.02855773,0.00016438059,0.052466683,0.014501584,0.05017552,0.043391008,-0.039000355,0.076467484,0.102750756,-0.028570253,-0.014533487,-0.098130696,0.03410626,0.052453425,0.105790354,0.050775256,-0.018990107,0.06823605,0.049260266,0.008036558,-0.100231215,-0.0653342,0.044006843,0.027070535,-0.0025635348,0.13062027,-0.0035754757,-0.038013622,0.0065657618,0.0034028154,-0.030637149,0.019400453,0.035257105,0.008232013,-0.045346633,0.05744746,-0.013981029,-0.011460897,-0.0048416825,-0.018016325,-0.033903494,0.0061874166,0.05466425,-0.036932677,-1.04558e-33,0.075859174,0.07128883,0.062451523,0.04658883,0.04240468,-0.011385864,-0.0407039,0.038605478,-0.09352582,-0.08982137,-0.0862091,-0.074231215,-0.111351125,0.0706691,0.04146627,-0.02055498,0.0337789,-0.060723186,0.07480031,-0.01711647,0.040351033,0.050021905,-0.06931025,0.023005787,0.06941539,-0.0074113207,-0.018652402,0.054731067,0.05084626,-0.019234044,0.0041933097,-0.04569046,-0.050693635,-0.002824363,0.05542439,0.023932425,2.583687e-05,0.005900217,-0.12123058,0.043138802,0.072784886,0.025896398,0.0046743234,-0.046232782,0.04675199,-0.021966934,-0.052372415,0.0124825,0.09493174,-0.040028032,-0.027964193,0.05492246,0.094869405,-0.015997045,-0.038005535,0.023411887,-0.061073717,-0.016557572,0.049854442,0.03091182,0.0194308,0.066100486,-0.070110545,0.015636232,0.017459136,0.11544666,-0.08220689,-0.0142895635,-0.010729411,-0.024586942,-0.053493988,0.009515832,-0.034542926,-0.07913305,0.114028245,-0.049165417,-0.069380164,-0.08525777,-0.011320062,-0.06691222,-0.089075424,-0.024800317,0.028870352,0.024625,-0.05586217,-0.048762597,-0.010808108,0.09787462,0.0011955587,0.010745376,0.014785723,-0.06925405,-0.06751126,0.047602694,-0.02111879,-5.177551e-34,0.033472013,-0.088800594,0.05269238,-0.08188492,-0.058769517,0.1304242,-0.011317365,-0.029764215,0.003233572,-0.05076991,0.008962218,0.019841257,0.086506195,-0.07997902,-0.019509705,0.019717693,-0.0017123987,0.103577085,-0.016379695,0.03395271,-0.010941202,0.012707891,0.06449376,0.026781775,0.017435262,0.0070754094,0.07337142,0.057054926,0.017905265,0.022456499,0.037231572,0.023005031,-0.006072067,-0.012957895,-0.15058479,-0.023264552,-0.06945863,-0.01846586,0.034481168,0.038626257,-0.019581402,-0.008479896,-0.014639059,0.11561179,0.120821714,0.028087469,-0.053031296,-0.007850472,-0.058772855,-0.011050697,0.0342714,0.00068075565,-0.006424057,-0.0248291,0.06545162,0.002445279,-0.0026564484,0.019118715,0.06508091,-0.057025783,-0.04946455,0.008183563,-0.10787661,0.012328256,0.08302536,0.05517165,-0.014001025,0.07922634,0.030712483,-0.065037146,0.09433707,0.036119573,-0.038992513,0.027363583,0.022835469,-0.0177014,-0.01996897,-0.047717966,-0.013033496,0.023236277,-0.020071274,-0.054287687,0.05657708,-0.061634924,-0.048909426,-0.04438776,0.062443595,0.010911651,0.0027651617,0.061087973,-0.032158848,0.057262108,-0.07634948,0.039709266,0.07375261,-3.5430713e-08,0.09622198,0.031323425,0.040745623,-0.0592766,-0.014869595,-0.026995536,0.086968206,-0.004831182,0.02277473,0.088175304,-0.07421136,-0.014260182,0.047257893,0.042738277,0.035312753,0.015432128,0.012171224,0.00666588,-0.0020973228,0.010352617,-0.0564363,0.036959067,-0.020894524,0.03128842,-0.066330574,-0.08412174,0.01516071,-0.031575367,0.024076056,0.037966043,-0.04725974,0.061843317,-0.018497568,-0.08127903,-0.014664141,0.054008197,-0.01917182,-0.06044527,0.017892571,0.042037595,0.012862734,-0.0917679,-0.040602334,-0.0458349,0.00079183606,-0.02796266,0.042606235,0.005716462,0.032288123,-0.020583466,0.029132117,-0.022666276,-0.021733146,-0.06846294,-0.06666198,-0.04879142,-0.026455712,-0.009989955,-0.06668104,-0.08781494,-0.047186065,-0.053153694,0.11636993,0.04737225 +4.2.3.130,Isolated from Bacillus subtilis. This sesquarterpene is present in a number of Bacillus species.,384,1.0,-0.030261058,-0.04964792,-0.04908054,0.03198986,-0.07247915,-0.0015322348,-0.063239135,0.06843872,0.0454034,-0.0887632,0.068754196,-0.11067266,0.095151216,0.012585908,-0.07406873,-0.013931056,0.034695543,-0.014889202,0.008556175,-0.0051969863,0.05552322,0.098701626,-0.051830925,0.0045043686,0.017844692,-0.034374475,0.020122426,-0.04988794,0.029735528,-0.03864983,-0.0280989,-0.02887826,0.07385482,-0.10487429,0.09157433,0.021819133,-0.01185365,0.043441202,0.1702692,0.036011387,-0.055581074,-0.0010603572,0.035310537,-0.099795625,-0.022892749,0.05219901,0.0056520784,-0.018650845,0.012183172,0.00093690807,-0.017016392,0.0040741954,-0.07476044,0.067822404,0.034675024,-0.10508002,0.009434096,-0.036396798,0.016663475,0.04988808,0.06382114,-0.013276532,0.08015552,-0.03984384,-0.061332617,0.016277973,-0.011201719,0.016271599,0.040524732,-0.06617967,-0.016157934,-0.01648179,-0.0107103605,0.07158991,-0.03616081,0.027358692,-0.015023845,-0.02313294,0.020579256,-0.043438803,0.061191924,-0.0055450094,0.035491064,0.12119299,0.019700676,-0.0004952133,0.03804923,-0.011741127,-0.0048951805,0.045786884,-2.0677679e-05,0.062353864,0.028497633,-0.10528745,-0.013246948,-0.046322223,-0.03967819,0.051579446,0.014023144,-0.01787902,0.016357165,0.039591946,0.01404368,-0.029528502,-0.084154636,-0.03549131,0.016417531,-0.06482293,0.10307721,-0.026595958,0.025388986,0.036161017,-0.004889961,-0.10319477,0.005118705,0.027729131,0.10113565,-0.008864894,0.009958114,-0.017301418,0.0270149,0.021713978,0.07117037,-0.037221394,0.0064380337,-0.021096693,-0.024475444,1.102996e-33,0.0028080486,0.015674919,0.03991864,0.028617863,0.00056073104,-0.0649066,-0.03719362,0.02150577,-0.095123336,-0.06791537,-0.078461416,-0.08139736,-0.019121265,0.07232895,0.028253216,0.037870977,0.07459123,-0.019197147,0.049992245,-0.112102166,0.04148422,-0.0012824669,0.01789199,-0.040390402,0.05058596,-0.083299235,0.052748606,0.020742245,0.034807727,-0.039770003,0.103622,-0.054631364,-0.06541158,-0.0559783,0.05113747,-0.03139851,-0.037112836,0.03311285,-0.080874376,0.045837253,-0.0052292678,0.08167673,0.031031977,-0.046348926,0.08207013,0.024466204,-0.050362192,0.03040257,0.095588945,0.00052343245,-0.021450361,0.021646898,0.032126836,-0.02803651,-0.012828316,-0.034804482,0.017180393,0.023600763,-0.0022584347,0.06535683,0.048246905,0.052807562,-0.09230538,0.0037283164,0.027331736,0.095458895,-0.106080785,0.020172704,-0.064263776,-0.05300806,-0.047796514,0.02685392,0.030884936,-0.06778482,-0.02756559,0.012058732,-0.052676834,-0.02224659,0.013551979,-0.021101514,-0.063478194,-0.040257007,0.035473615,-0.029474365,-0.086388074,-0.008109634,-0.006822399,0.0283807,0.029244348,0.0458833,0.01585375,-0.112144485,-0.107337914,0.0636886,-0.024299368,-1.1576777e-33,0.059846047,-0.042101864,0.018962715,-0.07139299,-0.05336503,0.06476125,-0.0013229228,0.04310696,-0.013387044,0.041713547,-0.015921688,0.082921185,0.0844994,-0.0014140854,0.01787159,0.06035637,0.06400434,0.08217201,-0.00059128564,0.010048352,0.007339011,0.07459542,0.041553274,-0.047956925,0.019061523,0.05413284,0.05354841,0.040691137,-0.021238642,0.010540054,0.006775597,-0.03550462,-0.052978054,-0.07815778,-0.1285947,0.05750903,-0.022207856,-0.09730281,0.0036410699,0.008887624,-0.055325992,0.07831807,0.0023445725,0.06945721,0.09862374,0.038722653,-0.0468868,0.030225158,0.011873527,0.011781018,-0.025045667,-0.045077913,0.043491066,-0.08932348,0.026955549,-0.053709738,-0.10469596,0.13148695,-0.04025029,-0.10307805,0.046771657,0.003112241,-0.024491595,-0.036503468,0.0452516,0.11668015,-0.019898713,0.00033335522,0.0036184834,-0.08445509,-0.027295714,-0.009075341,0.004598377,-0.05333201,0.020534607,0.029347828,-0.03368147,-0.07318787,-0.016653657,0.030183319,-0.018819006,-0.06412309,0.008143925,-0.03549702,-0.0067423433,-0.03963436,0.00086620566,0.017868832,0.06657381,-0.030080384,-0.06444964,0.027758382,0.025523975,0.036249463,0.07910425,-2.3707255e-08,0.10001567,-0.041366227,-0.022893054,0.031986114,0.006606758,-0.047662776,-0.026654178,-0.039988797,0.016109515,0.033306066,-0.059806194,-0.00499414,-0.03494111,0.014220876,0.06879466,-0.008090088,-0.00089762616,-0.04685324,0.012766871,-0.025435135,-0.036650896,0.011532498,0.0012950059,0.049275678,0.011260671,-0.120539345,0.045478906,-0.09470405,0.009144873,-0.02191967,0.024559055,0.029858507,-0.016011266,-0.03474443,-0.0012402213,0.012004745,-0.08109973,0.104967386,0.018380372,0.05578585,0.06317185,-0.051614106,-0.063435666,0.025829092,-0.023932425,0.06789107,-0.0619252,0.06056333,-0.029578794,-0.03990463,0.015507727,-0.04421896,0.037819102,0.040078346,-0.029023439,0.006472556,0.013289901,-0.019134564,0.020569595,0.0077129393,-0.050805546,-0.039307456,0.14699197,0.036957167 +4.3.99.3,Requires Mg2+. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine.,384,1.0,-0.045323256,-0.113938585,-0.08729767,0.1071792,0.086954005,0.01746084,-0.03406002,0.032245237,0.009172366,-0.0027748311,0.020442693,0.01360237,0.006363043,0.029427806,-0.010667673,0.058026187,-0.07519767,0.045183834,-0.021169381,-0.06584768,0.049327623,-0.01331953,-0.025325418,-0.053111546,0.058912054,0.017706731,0.056300897,-0.06668687,-0.011672213,-0.0012649877,0.02812298,-0.014050358,0.05889183,-0.043580774,0.044241372,0.10730327,0.017324481,-0.042856224,0.016850604,-0.03523943,0.022515886,-0.019775683,0.07299732,-0.042108126,0.047864243,-0.04778909,0.014585885,0.019425271,0.051654745,-0.024591817,-0.056494053,0.005489423,-0.10948077,0.024414347,0.0048281825,0.040466107,-0.050082903,0.033543307,-0.010242603,0.019316353,0.077740334,-0.012003609,-0.033571184,0.0028382167,0.046573285,-0.03948185,0.047991876,-0.04756374,0.08329273,-0.03805358,-0.03498138,-0.005221214,-0.009591882,0.036136772,-0.04328761,0.072776504,-0.023758803,-0.039713603,0.04174961,0.0289667,0.067200705,-0.019564318,0.099575244,0.06860668,0.119578764,-0.004662374,0.025533425,-0.027584411,0.08824961,0.05564142,-0.007047065,0.01800362,-0.035202798,-0.06428373,-0.059063926,-0.00039397934,0.013931573,0.018788021,-0.03383572,0.026651325,-0.011747473,0.036899608,-0.046615995,0.001290553,-0.07411321,0.029878411,0.010284074,0.022276338,-0.0012350511,0.023181029,0.075420074,0.020032922,0.038567185,0.013605484,0.0040117595,0.09469218,-0.014416564,-0.10221206,-0.060045995,0.0121423425,0.014218784,0.08432765,0.006234495,0.029298725,-0.01855967,-0.0083634965,-0.12150248,2.7436694e-33,0.062438354,0.12210467,0.060595345,-0.0253232,-0.054696914,-0.026850274,-0.0814199,0.031130388,-0.043735743,0.05249827,-0.041571997,-0.105429344,0.04443709,-0.02452833,-0.04403707,-0.04818111,-0.0217206,0.009761413,0.08317129,-0.015672462,-0.09290388,0.027476307,-0.11066628,0.0248583,0.0051521217,0.090141006,0.014062317,-0.022595199,0.046746843,0.028161563,-0.05171846,-0.030463269,-0.091761574,0.0134367915,-0.0028461197,-0.045424208,-0.06948276,-0.096136265,0.035681114,0.022315482,-0.04615596,0.0038230065,-0.023079328,-0.040175833,0.014714265,-0.053455435,0.00071129197,-0.013738866,0.055721305,0.029086756,0.028729986,-0.069512896,0.06898835,0.04797039,-0.059812695,-0.017727135,-0.041771773,-0.058596168,0.07066508,0.07659879,0.013401285,-0.04125341,-0.026950894,0.013678779,0.008935539,0.055308715,-0.064296655,-0.09532466,0.005818784,0.111959904,0.033003844,-0.07429802,0.092816874,0.026623713,0.013011737,-0.030803582,-0.0044506956,0.11230838,0.017889978,0.019694746,-0.03860376,-0.0686714,-0.03579902,-0.0044761584,-0.05413239,-0.011824991,-0.0020008737,-0.041526806,0.0066299383,0.0018073736,0.026491692,-0.07319038,0.011672281,0.05564427,0.010522772,-2.5702728e-33,0.023350917,0.00576486,0.013175698,-0.084033616,-0.08689901,0.06797887,0.00416302,-0.09731985,0.051852614,0.0053606825,0.049392983,-0.04411063,0.040149163,-0.13672094,0.03216054,-0.0067472947,0.035517737,-0.00061252416,0.0013138875,0.019209104,0.013738343,0.06731975,0.029219855,-0.00017636066,0.084768124,0.017263055,0.052917194,-0.0030846454,0.053359047,0.12863158,-0.044830024,-0.013681272,-0.059100784,-0.022316199,-0.020779945,0.0557365,0.002472782,0.021445965,-0.0309743,0.017163096,0.026758675,0.04774407,0.083440445,0.21498366,0.04386066,0.023763187,-0.04428674,0.04210779,0.0054931026,-0.10028253,0.021947723,-0.0059259296,-0.046627957,-0.0382291,-0.027996767,0.07261894,-0.0027841514,-0.018442718,-0.036619186,-0.07249529,-0.043663923,-0.11314961,0.034577064,-0.049091455,0.07200149,0.030083876,-0.041444663,0.054707073,-0.003924995,0.04485043,0.025366034,-0.02453329,0.08181888,0.09232761,-0.039404824,-0.0011666646,-0.066105,-0.032373104,0.042123552,-0.027244963,0.0056258813,0.030307947,-0.008791536,-0.07861732,-0.01829369,-0.105668634,0.0155934775,0.11209978,0.046826325,-0.0071267025,-0.08675919,-0.037724923,-0.016816165,0.059423957,0.0006664212,-4.5257917e-08,-0.029842395,-0.10110605,-0.012619347,-0.025784241,-0.012697853,0.08288547,-0.01608923,0.026566623,0.028082708,-0.0092329355,-0.016515875,0.0920725,-5.4595384e-05,0.012933976,0.042560138,0.0021933296,-0.03128901,0.013821037,-0.05168985,-0.05040958,-0.030401008,-0.054076865,-0.102246776,-0.00034205418,-0.028951408,-0.028726371,0.054791946,0.072326876,-0.032360315,-0.016414046,0.0032511672,-0.037474897,-0.052978985,0.030144017,-0.11224677,-0.04435693,-0.057193413,-0.033818975,-0.0014459161,-0.03484057,-0.01207592,0.041277196,-0.004357067,0.08723229,-0.06856728,0.034620184,0.037553143,-0.014338874,0.0022747964,0.066149466,0.005401309,-0.046433643,-0.036794662,-0.044337317,-0.0525564,-0.02426,0.03372095,0.024547832,-0.0014029439,-0.054034837,-0.03345496,0.023982529,0.114262104,-0.018308418 +6.2.1.38,Isolated from Pseudomonas putida. Forms part of the pathway of camphor catabolism.,384,0.99999994,0.009323622,0.017114747,-0.11145179,0.0084711155,0.026082588,0.09519319,-0.05983587,0.036656566,0.029254302,-0.005341833,0.0998014,-0.0636785,-0.034399193,0.054507237,-0.027971217,0.012136594,-0.076744094,0.02709533,-0.0048595937,0.06293884,0.0304057,0.108404785,-0.054605726,-0.00045792523,0.013915056,0.040351816,0.040385142,-0.022736996,-0.008462631,0.0074078036,-0.110103324,-0.064674936,-0.012051269,-0.055226132,0.06487618,0.0048146476,0.030510945,0.009711899,0.10072952,-0.004487483,-0.00060199376,-0.05772549,0.02794744,-0.11947828,-0.02676453,0.011351875,0.0445636,0.0241327,0.040140603,-0.08105207,-0.066011384,-0.038832206,0.032978896,0.06340923,-0.0036927604,-0.0033399314,0.04558606,-0.013933434,-0.06933838,-0.0062411386,-1.6239011e-06,0.018676063,-0.01199041,0.007391418,-0.021843761,-0.043608423,0.0007532508,0.038542103,0.04769427,0.01123472,0.030631427,-0.0645744,0.10278879,-0.007620342,-0.05355499,0.007609197,0.05565192,0.011259712,0.048733562,-0.021560512,0.04754651,0.04987227,0.04954515,0.02589428,-0.056553457,-0.0062135216,0.07061192,0.053932726,0.042441573,0.022513855,-0.028595027,-0.040567033,-0.070542075,-0.0747059,-0.035709616,-5.8375615e-05,0.062299278,0.05815127,0.06537657,-0.049636584,-0.008614298,-0.009987967,0.010952033,-0.094754875,-0.08579882,0.02426146,0.05191139,0.025064753,0.06589144,-0.020262687,0.01941464,0.03683674,-0.04071777,0.027440784,-0.0010757322,0.046894196,0.075496726,-0.119191594,-0.07746372,0.026234534,-0.03833775,-0.059363205,0.056087572,0.093591444,-0.02480779,-0.016946634,-0.08869652,-1.696966e-33,0.08550437,-0.0058142194,0.03521388,-0.029089808,0.09889664,0.032168724,-0.06333293,-0.027549086,-0.009268858,0.023984056,-0.09624517,-0.14377701,-0.027111657,0.025963424,-0.00015301854,-0.024263155,-0.063434295,-0.038330887,0.063061774,-0.049401496,-0.0008318291,0.08604355,-0.008360371,-0.07082352,0.07499887,0.028179849,0.0514005,-0.12161634,-0.0012526709,0.0052536163,0.1027806,-0.056224898,-0.09812102,0.016362816,0.03806178,-0.012733995,-0.038748853,0.02766606,-0.02781192,0.034017,0.12447159,0.04038056,-0.020785429,-0.0113944225,0.087551594,-0.07219729,-0.03941114,0.12818803,0.07888934,0.07652491,-0.013949944,-0.0090878345,0.030634515,0.022168783,-0.08249348,-0.037019532,-0.07746418,0.008768456,0.017688064,0.059985656,0.019341316,0.06739655,-0.039223906,0.050639153,0.032908455,-0.02826179,-0.09249641,0.017910367,0.046547316,-0.0189057,-0.0850629,-0.0031514172,-0.012069936,0.026640223,-0.038164835,-0.10650942,-0.027234595,0.06924913,-0.027720245,0.040353123,0.0075643435,-0.033610296,0.0059971176,0.00070784445,-0.12420474,0.09966977,0.02088109,-0.001533504,-0.0708224,0.034067743,0.05440602,-0.024556618,-0.081733964,-0.01933242,0.017401798,-5.25212e-35,0.05484817,-0.09226505,0.057915926,-0.085419685,-0.039139077,0.024558268,-0.07678695,0.057345398,0.019192481,0.02114103,-0.027506245,0.059665825,0.096005164,-0.034248933,0.02391933,0.015493915,-0.021114228,0.035036337,0.014028614,-0.022929002,-0.024013517,0.013135903,-0.0695963,0.013412362,0.06085901,0.03435542,-0.015238923,0.11078368,-0.008562828,0.03491489,0.10912455,0.049792707,-0.05276734,-0.03297182,0.026382372,-0.004171306,-0.08519236,-0.002327551,0.05568858,0.03376601,0.009650113,0.0220246,-0.041509278,0.01904343,-0.020228148,0.070786074,-0.06929379,-0.022147601,-0.00053555146,-0.0879183,0.0037763016,-0.06331243,-0.011234836,-0.059398074,0.07100829,-0.044405684,-0.08527368,0.02888253,-0.089309275,-0.0265221,0.043058194,-0.0058911648,-0.040723737,-0.014738171,0.06974027,-0.0013712329,-0.0005885273,-0.007971144,-0.038225673,-0.0028256502,0.01841919,-0.010660211,-0.050691806,0.046775088,-0.059926048,-0.0048165326,-0.05164286,-0.05415893,0.026976021,-0.015168589,0.033447634,-0.08379724,0.012339897,-0.08599214,0.074546225,0.016346546,0.012557751,0.10549113,-0.026167326,-0.006571463,0.02074295,-0.01043237,-0.011555398,0.02038637,0.03057865,-2.1455145e-08,0.094090536,-0.10269784,0.03174054,0.047507055,-0.115593195,0.016820112,0.026138337,0.01679599,0.011544078,-0.067579485,-0.04303755,-0.020025795,0.021905417,-0.0023283989,0.037673954,-0.0044019087,-0.05482414,-0.025283037,-0.03464945,-0.0034036706,-0.123577006,-0.06646141,-0.058447078,0.013782852,0.0059519457,0.014293423,0.0931328,0.0536278,0.025463855,-0.06471196,0.045079473,-0.024072714,-0.023066577,-0.005994085,-0.02829885,0.05121011,-0.0001114341,-0.011983491,-0.022962552,-0.007985002,0.067295566,-0.049472775,0.008042592,-0.02007041,-0.03064673,0.03007535,-0.00956163,0.015656507,0.013606801,-0.07707634,0.027818538,0.06450471,0.04371657,0.04355219,-0.06693419,0.022684807,0.031119276,0.009824032,0.007556047,0.038568016,-0.0369072,0.034541704,0.075219475,0.05962177 +1.1.1.328,"The enzyme, characterized from the nicotine degrading bacterium Arthrobacter nicotinovorans, catalyses the reduction of ""nicotine blue"" to its hydroquinone form (the opposite direction from that shown). Nicotine blue is the name given to the compound formed by the autocatalytic condensation of two molecules of 2,3,6-trihydroxypyridine, an intermediate in the nicotine degradation pathway. The main role of the enzyme may be to prevent the intracellular formation of nicotine blue semiquinone radicals, which by redox cycling would lead to the formation of toxic reactive oxygen species. The enzyme possesses a slight preference for NADH over NADPH.",384,1.0,-0.06909478,-0.015670784,-0.0016054336,-0.004789727,0.025304595,0.067305826,-0.010303801,0.07283913,0.03429813,0.0054934835,-0.049062148,0.021963447,-0.038810562,-0.0060357824,0.008335171,0.106428385,-0.077822044,0.007597638,-0.0143975,-0.021652475,0.036073484,0.012031689,-0.022149282,0.06603039,0.0071007614,0.03745684,-0.03759706,0.024974877,-0.026981173,0.06182791,-0.042977806,-0.05739271,0.023107696,-0.01640169,-0.0018439047,-0.034987558,-0.054181002,0.044123884,-0.003603246,-0.020570533,0.0051062033,0.056052834,-0.13457537,-0.015570832,-6.473754e-05,0.025280092,0.013891482,0.04671998,0.046373837,0.01029864,-0.046777863,0.00554584,-0.078641325,0.06363502,0.02065613,2.9671543e-05,-0.044109654,0.0043288507,0.041928507,0.035311837,0.065277874,0.015232224,-0.00069450773,-0.013244762,0.07325117,-0.06556197,0.029172782,-0.02406124,-0.005103677,-0.055559106,-0.07215403,-0.1004778,0.011003429,-0.0016814509,0.03260946,0.036738154,-0.10821759,-0.019416036,0.02668792,-0.030992145,0.0566605,-0.050062794,-0.013130377,0.18739648,0.016944336,0.00018253869,0.032926157,-0.03857671,0.06026999,-0.020465733,0.036125857,0.05498099,-0.033007998,-0.0044088354,-0.13991521,0.020703133,0.07483891,0.04050984,0.037015032,-0.015566044,0.031664167,0.0319598,-0.040598344,-0.14833176,-0.040069036,0.016375909,0.0062266085,0.034593754,0.08841235,-0.0075215143,0.018217027,-0.023884699,0.0072183614,-0.028161107,-0.032319017,0.20283808,-0.022051169,0.020911433,-0.082623154,-0.022114346,-0.0014320641,-0.0012641541,0.084806606,-0.015707327,-0.0067616226,-0.01010806,-0.09201063,5.771686e-34,0.052437708,0.048877466,0.0019787375,0.05371284,0.034941845,0.022242546,-0.076018065,0.08581608,-0.02978703,-0.037852246,0.00865417,-0.078798436,0.014972077,0.033403084,0.013814294,-0.02386479,-0.065695375,-0.08401215,-0.014107203,0.036133908,0.0061382605,-0.004724133,-0.053371925,0.041035634,-0.037393406,0.008226818,-0.075618714,0.050998412,-0.031303138,-0.0020222925,0.050609495,-0.026177935,-0.09817877,-0.079484545,0.05876381,-2.1463824e-05,-0.06030241,0.0110344505,-0.098255485,0.050998297,-0.016090138,0.045177013,-0.02394339,-0.018543432,0.042756353,-0.07201897,-0.02695273,0.07957384,0.07848882,0.043045476,-0.03637349,-0.06214583,0.113463774,-0.05053267,-0.042988844,0.09119023,0.064038955,-0.020459343,-0.038651865,0.01964858,0.036370315,0.008131065,0.01620577,0.044851713,-0.021026548,-0.027665725,-0.028076155,-0.061814655,0.039255295,-0.012351797,-0.029701812,0.028048757,0.057273358,-0.058383744,0.019316444,-0.08739331,-0.05423544,0.022729475,-0.009504279,-0.015667766,-0.048807453,-0.07061169,0.032151725,-0.01731971,-0.059172332,-0.027932206,0.06316403,-0.031460237,-0.010120505,0.016238868,0.0392228,-0.0897621,-0.04150714,-0.032648277,0.0004050883,-2.0282758e-33,0.0050533577,-0.03446136,0.007115205,-0.05677601,0.023448851,0.03562395,0.06840213,0.0050885216,0.008089334,-0.015542269,0.0648335,0.04580229,0.07661818,0.044635545,0.03130603,0.029844403,0.027902614,0.02614189,-0.018851196,-0.022999203,-0.037577625,0.10087476,0.021365084,0.0026847518,0.017651811,-0.010115942,-0.022595532,0.056423474,0.11230441,0.055797625,0.027775174,0.09558181,-0.029240182,-0.019466398,0.06487436,0.08913114,-0.036444917,-0.057751082,-0.0019732767,0.035121914,0.0446935,-0.071630314,-0.07666971,-0.031191377,0.032699976,0.01951351,-0.08254822,0.07040218,0.0077065295,-0.019635806,0.11224485,-0.011939524,-0.057280123,0.045115564,0.074476644,0.018493889,-0.054127693,0.033325016,-0.02399535,0.009872808,-0.03707799,-0.017865397,0.00977803,-0.01098789,-0.023427734,0.021903252,-0.046021394,0.01947958,0.07314363,-0.12216918,0.04399939,0.0014253323,0.024171306,0.06347453,-0.082353525,-0.065883376,-0.011544977,-0.04951451,-0.05920247,-0.00733287,-0.055906836,0.048573155,0.015942551,-0.05144769,-0.0753053,-0.07059635,-0.08878589,0.067266606,-0.0816739,-0.023275634,0.035991527,-0.02536878,-0.02386996,0.053227592,-0.03652157,-3.6871636e-08,0.04281395,-0.10249054,0.13267353,0.0090489425,0.023441756,-0.0028986512,0.059765477,0.009034786,0.030514449,0.0069217617,0.045860708,0.040457558,0.01345014,0.0190425,-0.027300717,0.033503767,-0.03182007,0.039300054,-0.06564522,0.027889203,-0.09455053,-0.018616742,-0.0777732,-0.027256802,0.010518411,-0.033880867,0.012595633,-0.039580695,0.040624227,-0.028317288,0.056001555,0.03147417,0.05135299,-0.010956914,-0.1367695,0.0009029359,-0.0775021,0.01275697,-0.05169369,0.0062739956,0.0012066123,-0.04417346,-0.124252796,0.028001826,0.067801155,-0.050504956,-0.021680033,0.03193382,-0.019933391,0.019476581,0.0101465555,0.014132227,0.06320094,-0.077777684,-0.07105715,-0.01854475,0.02099596,0.033087518,0.014877163,-0.08687827,-0.012419396,0.026687006,0.15957144,0.023735616 +1.1.1.329,"Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC 1.1.99.38, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent).",384,1.0,-0.052066423,-0.0037424804,-0.0610941,-0.02263566,0.042786125,-0.01825229,-0.0512104,0.080451705,0.01821389,0.04222021,-0.04732878,0.009154389,0.118899554,0.09937151,-0.028975852,0.00296608,-0.057356942,0.016700782,0.00027999937,-0.0044792383,0.0049328846,0.103210285,0.058387857,-0.02116553,0.017790958,-0.0650697,-0.025392016,0.042846233,-0.07519801,0.011407078,0.036106534,-0.009461741,0.0573619,-0.033059247,0.031507198,0.0786417,-0.055912893,0.040255237,0.08620819,0.044540554,-0.04180242,0.05311911,-0.018474402,-0.031092487,0.007963235,-0.034138426,0.030910019,0.022910262,0.00012580304,0.06621693,-0.105603956,0.03755301,0.017037118,0.016046923,0.066214696,0.07870857,-0.038550533,-0.037585348,-0.04685752,-0.060670406,-0.019469574,-0.09198412,0.0009916283,-0.0047362936,-0.050926387,-0.016622413,0.03739586,-0.06023293,0.02875015,0.0017567092,-0.006878835,-0.08753113,0.010184021,0.053599093,-0.07156127,0.02852757,0.042419553,-0.091947444,-0.0567991,-0.07697311,0.029717386,-0.007776623,0.012821593,0.102883086,0.13555191,0.035246518,0.05690616,-0.0031275635,-0.032823846,0.11522245,0.07099183,-0.024658846,0.038977336,-0.045087848,-0.058060363,-0.066817984,0.059219815,0.025754632,-0.030755498,-0.0014715432,-0.023327835,-0.0012576517,0.018133461,-0.030357888,0.025228227,0.016405936,0.088006996,0.0179398,-0.057537246,0.012401367,0.04517083,-0.06842077,0.0062814276,-0.0008512001,-0.010158391,0.08071254,0.12782443,-0.04796272,-0.06206211,-0.010295317,-0.0065312022,-0.012672767,0.0016115073,-0.0077587413,-0.048474148,0.05791232,-0.012664853,1.6259875e-33,-0.00025248248,0.06513427,0.025775818,0.032074697,0.054918136,0.052536353,-0.043583333,-0.0302633,0.043561064,-0.08048317,-0.11954588,-0.05801148,0.06036408,0.0313401,-0.085549794,-0.032842025,-0.020812681,-0.033821974,-0.014565231,0.060031913,0.028235257,-0.013465473,-0.07809952,0.023787828,0.0035442156,0.003252494,0.0016974397,0.023107339,0.05260406,-0.014529137,-0.022436915,-0.0454209,-0.040422685,-0.047565766,0.065563545,0.01748223,-0.05866984,0.0135923615,0.084965125,0.034300856,-0.019093536,0.0013588095,-0.079555616,0.03827529,0.057775173,-0.0011087419,-0.046564825,0.09115944,-0.038505405,0.014967612,0.102611676,-0.008245577,0.018187284,-0.08377197,-0.090909794,0.019652758,-0.020722777,-0.021705706,0.045501143,0.07400098,-0.019372359,-0.04360195,-0.0105343405,0.042497057,0.06414178,-0.024132019,-0.074289024,-0.10143179,-0.09337669,-0.02027092,-0.0820145,-0.06643232,0.09071648,0.07036706,-0.0071141,0.03496152,-0.049771823,-0.03152201,0.09833891,-0.0348066,-0.04004552,-0.068085164,-0.048174046,0.044814575,0.014690816,-0.019802041,0.0029846295,-0.05370038,-0.0018217921,0.019428283,0.002622191,-0.11296202,-0.09127755,-0.00400669,0.0068171066,-4.523594e-33,0.044182558,0.022195145,0.08304638,-0.045142088,-0.016126884,0.11665579,-0.01031941,-0.12941389,0.11406126,-0.044661768,0.11641882,-0.014042879,-0.0229515,-0.01373808,-0.003182089,-0.012015937,-0.06416109,0.047929127,-0.009857991,0.00042926884,0.050399806,0.027333776,-0.009598882,0.025652442,0.0048104897,0.078948416,-0.08134004,0.034474976,0.042966533,0.09867953,-0.042253327,0.030267226,-0.032638434,-0.091541655,5.224221e-05,0.104688585,-0.0745363,-0.00852369,-0.04436844,0.003727925,-0.04505355,0.008465246,-0.023303818,0.11276884,0.042135846,0.024290238,-0.07062033,-0.007869869,-0.02429016,-0.052457366,0.049645092,0.049636643,0.02211988,0.008743521,0.0075951694,0.025920434,-0.00080761436,0.017526928,0.03552245,-0.031262264,-0.023229916,-0.0020360907,0.01168103,0.0071375463,-0.06579822,-0.040457215,0.01556771,0.025775172,0.03698356,-0.063840576,-0.019144354,0.04739203,0.053306554,-0.0028122303,-0.027766876,0.02436953,-0.10661671,-0.06819052,-0.020065906,0.020559993,-0.015891192,0.051636893,-0.025360264,0.033665035,-0.046771515,-0.030081647,0.060026966,-0.024468133,-0.032638066,-0.012817629,-0.053294577,0.0057405354,-0.04002023,0.03343552,-0.019513633,-4.16522e-08,0.085927345,0.01396551,0.053183638,-0.04886023,-0.008270337,-0.04963317,-0.03570002,-0.02482995,0.04191577,-0.028973768,0.04390721,0.15103325,0.013802221,0.0208596,-0.016209615,0.075109385,-0.05121196,-0.016403366,-0.03168068,-0.008675475,-0.0860552,-0.00770591,-0.103986755,0.03683498,0.07268131,-0.03691784,0.0070164236,0.0125692235,-0.006129975,-0.033333544,0.070486456,-0.054173045,0.0057333084,-0.01620962,-0.06838355,-0.034899965,-0.061909672,-0.062872864,0.04053068,-0.04919479,-0.017458988,-0.0039087804,-0.050210353,0.041917644,-0.010307341,-0.035011284,-0.032229353,0.036563076,-0.055755917,-0.020635704,-0.01043053,0.010013137,-0.023659902,-0.033698406,-0.04268231,0.08216711,-0.020179292,-0.0406619,-0.035351608,-0.06484245,-0.085787736,0.009514512,0.16008548,-0.07499695 +1.1.1.330,"The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.",384,1.0,-0.097542055,-0.09037575,-0.06982491,-0.022896105,0.089296065,-0.003445825,-0.1444502,0.010836547,-0.0030996767,-0.07451925,0.10956687,-0.06994085,-0.067790575,0.01883144,0.0064468617,0.010561838,-0.08311002,0.021000559,-0.025871465,-0.10354105,0.07137991,0.03450853,-0.040781286,0.058812585,0.05734898,-0.05742939,0.06435937,-0.027496116,-0.061426714,-0.11999298,0.008480985,-0.014143462,0.082560025,-0.03237504,0.08017095,0.07035895,-0.004627309,-0.09249786,0.032299288,-0.055176612,0.10105037,-0.05175208,0.033348605,-0.016255256,-0.062551625,-0.061021104,-0.026329063,0.061461955,0.010080837,0.03493336,-0.015185544,-0.06965228,-0.049969662,0.052583747,0.023668366,0.016116356,-0.010387212,0.012461128,-0.0261659,0.032647505,0.079780884,-0.023648098,-0.009743635,0.007922855,-0.007377164,-0.06458944,0.07048981,0.00047348492,0.0011507873,0.0032939054,-0.015209816,-0.07800547,-0.038504843,0.1016963,-0.011283538,0.009604977,-0.022810757,-0.004578387,0.019854672,0.012783984,-0.046409015,0.01680608,0.039298624,0.028800106,0.07151302,-0.03698446,0.00048145707,-0.030556593,-0.02276121,-0.021018056,0.03061708,-0.0470128,-0.038064748,-0.008214997,-0.036167633,0.08330043,0.010900794,-0.03850481,-0.042838562,-0.031985063,0.01567104,0.103587225,0.04421269,-0.027312618,-0.028088845,-0.014789586,-0.054760456,0.11172026,-0.0081375195,0.009202717,0.020985873,-0.017022597,0.0920345,0.029048976,0.014584339,0.05144843,-0.059631076,0.0066762688,-0.033539172,0.047748473,0.044844046,0.028199838,0.0075593987,0.049895037,0.040661328,-0.0014332151,-0.11617795,-1.0562663e-33,0.035368115,0.010103253,0.020676179,0.0735404,0.022943184,-0.031143412,-0.060829762,0.105115995,-0.09333288,-0.0004738424,0.03624291,-0.018902233,0.09511613,0.071188964,0.016220791,-0.05739165,0.0076286006,0.024453968,0.042972904,0.030573344,-0.032878526,0.020855712,-0.006152601,-0.035677522,0.021292772,-0.03811347,-0.03253582,0.036644623,0.047652837,0.027516473,-0.045413874,-0.05541266,-0.058070786,0.038205277,0.04424253,-0.0747282,-0.0041520414,-0.09699076,-0.030396093,0.103566974,0.0929143,0.021969775,-0.018824404,-0.051487092,0.018454792,-0.05789982,-0.0057875738,0.062404163,-0.026496446,0.028825345,0.07429173,-0.0119062355,0.105948225,-0.04883973,-0.022105554,0.031229144,-0.10103215,-0.0044025686,-0.007606195,0.018019635,0.02476998,0.05905048,-0.04286122,0.06708292,-0.019188143,0.010941269,-0.11395317,-0.04386314,0.009316295,0.03445023,0.035446122,-0.039286796,0.059220728,0.06694999,0.05026872,-0.050678987,-0.077608496,0.069956236,0.00052154186,0.008098673,-0.022527598,-0.03401309,-0.004101071,0.0015709901,-0.028085727,-0.039262183,-0.004558996,-0.023677517,0.04932276,0.033941798,0.019776734,-0.05040422,0.0077577652,0.01900971,0.03902634,3.3671182e-34,0.12627153,-0.117115006,0.03513456,-0.16114214,-0.046738565,0.025715547,0.05095923,0.04291084,0.008060958,-0.022455387,0.093369626,0.029264323,-0.046653744,-0.110369,0.06353626,0.066300265,0.029684335,-0.027365688,0.029756622,-0.03652327,0.043061584,0.007271482,0.08271195,0.029779838,0.04840543,0.04206561,-0.03682989,0.029566268,-0.021703929,0.0502964,-0.06106739,-0.03197602,0.015210461,0.029002089,-0.07653077,0.047674045,-0.090408765,-0.004514095,0.038702738,0.013155585,-0.019972574,0.07244571,0.006698752,-0.014618933,0.07741433,-0.026436377,-0.008244885,0.02495362,-0.02040935,-0.11085204,0.016363315,-0.008374582,0.00728566,0.014797913,-0.011680765,0.025807887,-0.0023866023,0.01668621,0.040913932,-0.056805763,-0.03989168,-0.002704132,-0.0076096123,-0.014241977,0.079799294,0.058942858,-0.009300116,0.033323556,0.029215643,0.022956142,0.056755077,0.01650483,0.020278795,0.055389285,-0.025386272,-0.060096283,-0.06282815,-0.03562346,-0.061434444,-0.07637601,-0.06441354,-0.0786433,-0.05246124,-0.048643503,-0.035812736,-0.07280483,0.014742383,0.09406767,0.04838624,0.04495279,-0.04359574,-0.0132725015,-0.046778593,0.10709969,0.10876469,-4.2986642e-08,0.06509205,-0.062336527,-0.013684182,-0.050835468,0.054361317,0.04495618,0.017666213,-0.011895253,0.06660176,0.012962901,-0.02564087,0.06966797,0.08419529,0.026205257,-0.0013648724,-0.0060357586,0.0452711,-0.0027343486,-0.010384431,-0.02613447,-0.013435816,0.01980272,-0.065376624,0.096422635,-0.0501421,-0.02827615,0.0155954445,0.04188068,0.010121542,-0.04569755,0.01364385,0.057188805,0.018607918,0.05670728,-0.023968795,-0.024245886,0.009014949,-0.05555861,-0.085740186,0.092356905,-0.0057886047,-0.016977217,-0.046893787,0.0035022814,0.103932396,-0.049971227,0.014682869,0.034665424,-0.0014483542,-0.007989341,0.009925559,0.027400702,-0.048139036,-0.026432108,-0.0684847,-0.03386542,-0.033612054,-0.0417802,-0.03390317,0.00545995,0.017878095,0.0014303642,0.16418815,-0.056290835 +1.1.1.331,Isolated from the plants Forsythia intermedia [1] and Podophyllum peltatum [1-3]. An intermediate lactol is detected in vitro.,384,1.0,-0.03524239,-0.0699058,-0.06481087,0.073125295,0.052612033,0.09308944,-0.031729497,0.04269366,0.047350194,-0.034831814,0.021986544,-0.028543077,-0.07494498,-0.018022548,-0.053567786,0.042817567,-0.049332656,0.05084235,-0.05542197,0.048831582,-0.03002781,0.011710422,0.04534398,0.08015533,0.042253263,-0.0041471617,-0.05039894,0.059123483,0.010795647,-0.07776683,-0.055693828,-0.035394322,0.07952038,-0.0331683,-0.030405197,0.05906457,0.056782022,-0.10230382,0.014674639,-0.031050725,0.05045192,-0.06618969,-0.08734565,-0.0059263255,-0.022699207,-0.020721285,0.01121606,0.06571918,0.006546673,-0.04024531,-0.05031355,-0.07947528,-0.041777357,-0.005669885,-0.05569054,-0.008752428,0.07212672,0.030339843,0.053325918,0.1246492,0.04425509,0.041933756,0.02719892,0.050448522,-0.086040355,0.05170825,-0.035984214,-0.0159291,0.04814515,-0.03071028,0.010707487,-0.12560143,0.08686935,-0.015134461,-0.036494486,0.09346284,0.0044325027,-0.013641558,0.030577587,0.06375609,-0.042202566,0.013335371,0.016243892,0.062283624,-0.024925794,-0.010557833,0.04594411,0.049850363,0.0095788045,-0.0015511804,-0.025981836,0.035039596,-0.037274554,0.09034702,-0.037220445,0.09094083,0.10083573,-0.04113666,0.041093122,-0.045870874,-0.021793406,-0.007979154,0.026819408,-0.085840896,-0.0657806,0.02754634,-0.0106461765,-0.046400547,-0.0146521395,-0.0802063,-0.05788364,-0.008793363,-0.06480018,0.023987861,-0.060131703,0.024993412,0.053834576,-0.10059398,0.07239042,0.059683204,-0.026117055,-0.024756348,0.09003045,0.0051712566,-0.033356477,-0.0045168307,0.012360702,-3.4739316e-34,0.0006962392,-0.036161482,0.021870539,0.07095197,-0.012486484,0.039588496,-0.030057829,-0.015488469,-0.08841211,-0.03825012,-0.036076907,-0.0013678905,0.0036582013,-0.02956907,0.01229552,0.022502463,-0.025409447,-0.0107903965,0.07808274,-0.015134023,-0.0011500726,0.03813981,-0.11039461,0.0021161644,-0.027968455,0.02374857,0.015830727,-0.07815172,0.03177427,0.0066983504,0.0942364,-0.0750134,-0.085648365,0.023285514,-0.010894012,0.058849756,-0.07840247,0.023054788,-0.029378759,0.10106508,0.021446941,0.054837763,0.035743337,-0.0027184621,0.027380535,0.026892923,-0.02656634,0.032578327,0.077788405,-0.025748398,0.00408605,0.020411551,-0.077897266,0.017302379,-0.021192046,0.04063888,-0.022630531,0.116204396,0.051457707,0.026770497,0.022125324,0.07812622,-0.013942821,0.012718193,0.04218459,-0.0022177666,-0.106924705,0.005656876,-0.043502048,-0.011335854,-0.061530527,0.02479726,0.01327833,-0.013669016,0.04171105,-0.03632846,-0.014583989,0.06093759,-0.023366848,0.06284992,0.038839616,-0.050136674,0.034499858,0.040882405,-0.07161296,-0.0084284,-0.058936838,0.11640112,-0.05318783,0.025404608,0.08112679,0.046623006,-0.07844013,-0.044178527,0.03985207,-1.1688318e-33,0.08937686,-0.06214956,0.11571825,-0.01085603,-0.062397305,0.03269736,-0.08073494,-0.030940661,0.018991698,0.12529324,0.069803,-0.029289765,0.047163293,0.0011454708,-0.076479286,0.0064320993,-0.004092232,-0.024838816,-0.014621602,0.0011119593,-0.03711627,0.005728682,0.039930437,-0.09668065,0.012912632,-0.0026204474,0.013303254,-0.04710813,-0.071528375,-0.00079856394,0.034687564,0.012231887,-0.049130987,-0.03629255,-0.013897263,-0.10305162,-0.06237195,-0.05093917,0.06636637,-0.028093245,-0.079703264,0.01915058,0.007731565,-0.016078465,0.047019806,0.06390599,0.0059262947,-0.018521298,0.011656455,0.116163105,0.0037520356,0.021111457,-0.08291235,-0.026272433,0.004835594,-0.034711204,0.04394304,-0.028217727,0.043038595,0.009931895,0.08037956,0.020681877,0.020094927,-0.03805266,0.00038381887,0.08765374,-0.06157635,0.06143461,-0.019778658,0.002643131,0.029098997,0.054639526,0.010502472,0.017441487,-0.04262399,0.05935407,0.0425368,-0.10379928,-0.07166699,-0.063399814,0.120612875,-0.016191196,-0.009849189,-0.03241858,0.01829347,-0.013790672,0.034281325,0.045581635,0.019650616,-0.022928426,-0.015722163,-0.004127946,-0.066545576,-0.01390584,0.12643711,-2.749936e-08,-0.07572455,-0.0124113,-0.0650568,-0.036761064,0.009574198,-0.026650567,-0.103787504,0.006631336,0.04737993,-0.035514936,-0.02264141,0.05579,-0.0030787056,0.042650495,0.031055568,-0.06150034,0.08093453,-0.072142415,0.053644396,0.048400316,-0.039825734,-0.04531047,-0.026467182,-0.009773143,0.0424557,-0.022018706,0.0797107,-0.027261928,0.055369005,-0.0833223,0.053200755,0.025280504,-0.030707426,-0.01908921,-0.0076302406,0.057206906,-0.06725799,0.0022501722,-0.1415721,0.0007714006,0.058793884,-0.09077682,0.08756478,-0.053509217,-0.014799797,0.003731218,-0.005040325,-0.021089835,0.04229094,0.023827815,0.007005924,-0.06983388,0.064874336,-0.014494058,-0.071197994,0.017453335,0.04005565,-0.019273575,-0.039247576,-0.04279387,-0.07663294,-0.035167895,0.09634767,0.026983043 +1.1.1.332,The enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.,384,0.99999994,0.0027678045,0.027542597,-0.10388047,0.014045311,0.048040155,0.03755365,-0.042249173,0.042800445,0.051803883,0.0030672413,0.038423903,-0.070156716,-0.06128239,-0.054397136,-0.053829715,0.023805948,-0.053956013,0.078345254,-0.017385323,-0.06294925,0.06453388,0.03329567,0.043795366,0.031150237,0.060691286,-0.04706173,0.04638103,-0.0480221,-0.051902633,-0.15100378,-0.04078316,-0.06679624,0.047765378,-0.037935004,-0.010926841,0.049062178,-0.048474055,-0.021826059,0.03071265,0.03702448,0.0054182652,-0.019323794,-0.013847585,0.026346931,-0.10394778,-0.010022069,-0.050450787,0.04033044,0.012251743,-0.028626733,-0.016155964,0.011404825,-0.03448396,0.0051290966,0.03943947,0.008615672,0.0013505557,0.02907866,-0.032738846,0.029961675,0.11143182,0.0072001186,-0.057230692,-0.0212518,-0.08961175,-0.035031322,0.04509031,-0.059266947,-0.067507975,-0.03622879,-0.062649556,-0.07843765,-0.05290269,-0.014597527,0.07591128,0.08912094,-0.0011749765,-0.014743625,-0.094792046,0.013819975,0.06389797,0.07756798,0.07639806,-0.0011146863,-0.023938883,0.019701693,0.008746094,0.07121474,0.054459058,0.05344483,0.09619165,-0.051898815,0.008783558,0.0092733,-0.031311262,0.08171934,0.04429641,0.06647983,0.027801756,-0.051996358,0.047550585,0.015503181,-0.018018616,-0.031150138,-0.015843619,-0.009829313,-0.011265044,0.023047077,0.032032996,-0.062840596,0.041582834,-0.038589306,0.04746976,-0.00972178,-0.03996128,0.06569224,0.029719636,-0.0713445,-0.10176632,0.05616379,-0.0027494123,0.014028764,-0.016438277,0.035098925,-0.0011496865,-0.068252325,-0.06152135,9.70236e-34,0.09641818,0.054140005,-0.12073124,-0.027383767,0.05062545,0.041773472,-0.06387349,-0.04172612,-0.050773446,0.0023881774,-0.09083104,-0.053292885,-0.022146976,-0.01355511,-0.021815736,0.04722072,0.006105177,-0.015373612,0.053061124,-0.006984045,-0.009412171,-0.014635733,-0.13604648,-0.035328384,-0.032693848,0.11102343,0.0037095093,0.022609081,-0.010763491,-0.035331998,-0.012598715,-0.10376438,-0.074446954,0.097920775,0.040730946,-0.034128334,0.064780734,-0.004461966,0.04855865,-0.05799738,-0.00263444,0.11843385,-0.0051085707,0.0010457527,0.05955052,-0.013857917,0.01139212,0.084819876,0.10816575,0.0850796,0.004632588,-0.016027702,0.11638205,0.06396383,-0.0497224,0.050287865,-0.04210575,0.022312896,0.02808837,0.061001524,-0.01200297,0.04469897,0.016864568,0.04355316,0.025766313,-0.0012501524,-0.01562927,-0.07415872,0.028120352,0.05431545,-0.034311358,-0.05563109,0.050503764,-0.025286166,-0.055928376,-0.031956505,-0.033386514,-0.009364397,-0.032523684,0.026997773,-0.015272901,-0.010307255,-0.03852886,-0.0052960357,-0.039485533,0.035290863,-0.054893263,-0.029367128,-0.026962148,0.072387725,-0.028091492,-0.007618117,-0.055713445,0.0502941,0.044181734,-2.0270956e-33,0.17239441,-0.089372136,0.021417752,-0.06432601,0.005926226,0.05075689,0.014713011,0.059462603,-0.042626068,0.0346129,0.03743921,-0.002263286,0.02410236,0.0015631564,-0.028108444,-0.06419137,0.043188125,0.12779082,-0.0008586385,0.02613016,-0.08563099,0.07474665,-0.09528206,0.04576157,0.033934876,0.018138388,0.0235243,0.032228526,-0.09316223,0.022824088,0.0068167658,-0.009238869,-0.053107742,-0.016455881,-0.035773214,0.09521355,0.020702468,0.03025376,-0.01868765,0.026520627,0.018278653,0.0091336565,0.01405841,-0.0075735743,0.088485435,0.060164608,-0.033070277,0.059546717,0.0037659537,-0.09149017,0.049658276,0.05230156,0.048986237,0.0142328795,-0.008812207,0.027441774,0.048153833,-0.03849527,-0.01295955,0.022511065,-0.057099804,0.001622184,0.03773274,-0.014552324,-0.0210748,0.026619848,-0.040246844,0.0023085007,0.093232594,0.017098885,0.08271538,0.029028593,-0.01852347,0.08484424,-0.04899686,-0.028467886,0.0004302017,-0.06279226,0.04580355,0.011009609,0.040443804,0.02702939,0.041952126,-0.096134394,-0.01802357,-0.0912699,0.02600379,0.07546279,-0.06306628,0.0450407,0.07380464,-0.042631596,-0.034768216,0.08010812,0.04904123,-2.2364672e-08,0.040029384,-0.021556301,0.02657885,-0.047506534,-0.019887056,-0.025150781,0.07567615,0.00010245972,-0.008917534,-0.019092087,-0.06202415,0.026921267,-0.03257705,0.095190324,0.12309276,-0.009981533,0.017874742,0.058898013,-0.019742554,0.026429044,-0.0044724885,-0.042788286,-0.059006352,-0.034345135,0.035671063,-0.038490154,0.005806301,-0.018310243,0.07892964,0.04926872,0.037327435,0.0019060051,0.0046469364,-0.033919852,-0.012209915,-0.021682987,-0.06565707,-0.069034584,0.012287771,-0.07159094,-0.03308796,-0.049419306,-0.028320588,-0.013710551,-0.12246549,-0.027889369,-0.028803952,-0.020844216,0.052364085,-0.01779839,0.0751293,-0.057303358,-0.006755554,-0.09842553,-0.10594735,-0.0370045,0.058781847,-0.04494139,-0.02041323,-0.08272117,0.020492412,-0.015575513,0.10041859,-0.030238109 +1.1.1.333,"The reaction is catalysed in the reverse direction. The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.98.3, decaprenylphospho-beta-D-ribofuranose 2-oxidase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.",384,1.0,-0.044480447,-0.0085212,-0.03854594,-0.03275113,0.013143068,0.006359438,-0.024020186,0.062603265,0.032933798,0.07021276,-0.0136827305,-0.017335469,0.04728947,-0.00077477616,-0.055208467,0.043151442,-0.019991165,0.06444078,-0.0033494644,-0.0010684063,0.04581334,0.017798653,-0.011172178,-0.075046144,0.10161045,0.03331708,0.02282924,-0.014947671,-0.04953649,-0.089045525,0.048190914,-0.07040488,0.07090971,-0.060520183,0.103541866,0.0865737,-0.014075964,-0.100232445,0.08907016,0.016047524,0.072506,-0.01763147,0.03968613,-0.067780636,-0.0050146496,0.029223612,-0.048514534,0.07391454,0.045565557,-0.019525353,-0.034676984,-0.04796144,-0.06775837,-0.04997384,0.020073544,0.051504206,0.025110442,-0.037346672,-0.0016992626,-0.013885646,0.051083386,-0.02223875,0.006650377,0.045455877,-0.038770795,-0.057844646,0.013572704,-0.01744727,0.03625365,-0.030086491,-0.047606014,0.011293156,-0.045959536,0.060294587,0.061473593,-0.039748773,-0.02175199,-0.060259074,-0.0009642009,0.04371504,-0.043595858,-0.05871445,-0.023614682,-0.032446623,0.009494522,-0.005417785,0.07856898,0.037054107,0.04685155,0.10349771,0.025743762,-0.0357115,0.041784447,-0.046694748,-0.0071432455,-0.032301266,0.04523553,0.0662723,0.017917601,-0.04558357,-0.011246401,-0.03799048,0.03197362,-0.102590255,-0.04280126,0.01031211,-0.07669986,0.05354354,0.034317058,0.0021231687,-0.044832356,-0.0037272226,0.005509637,0.0013013826,-0.01959688,0.10460709,0.062591955,-0.08151449,-0.06929215,-0.044727296,-0.0030790528,-0.058106035,0.044303417,0.009729204,-0.14469714,0.06008421,-0.100577295,3.204027e-33,-0.032773275,-0.017383598,0.01631831,-0.038226094,0.0014369992,-0.04920234,-0.105228566,0.00010571357,-0.065132655,-0.03481184,-0.11475883,-0.05557491,0.05011951,0.08895902,-0.06960698,-0.0025109733,0.021454627,0.00918966,0.054624792,0.032066766,0.017284708,0.032312263,0.021975758,0.025406722,0.025039593,0.0126471,0.020045742,-0.015199548,0.06576271,-0.006384511,0.025671855,-0.020839117,-0.037474547,-0.03891457,0.020110192,-0.0017486553,-0.07712236,-0.064153984,0.0062096585,0.034490284,0.041666128,-0.0064326455,0.0068933386,-0.008190163,0.07892359,0.026312253,0.024446063,0.0010657922,-0.0026411263,0.029054252,0.037037116,0.01671306,0.040401235,-0.04193822,-0.017179301,-0.033259585,-0.03817797,0.011681002,0.016783612,0.022618432,0.020564605,0.12520775,-0.0074165496,0.044614106,-0.060935102,-0.026311956,-0.029992023,0.02618678,-0.009925618,0.011269988,0.003134609,-0.032046195,-0.007950287,0.012951583,0.09616694,-0.02089126,-0.06647889,-0.004844985,0.014844779,-0.064035766,0.035129935,0.09973072,-0.0908793,-0.05602551,-0.0041570025,0.01660769,-0.020988386,-0.01768492,-0.03341985,0.033367176,0.023400558,-0.09760814,-0.045546222,0.052102614,-0.0022002219,-5.7146353e-33,0.1001919,-0.17422447,0.07330071,-0.06548548,-0.0037358943,-0.033656053,0.058079097,0.027371038,0.081918545,0.015453668,0.061326575,-0.018962631,0.033786554,-0.07166433,0.020051787,-0.035025172,0.055398848,0.03811035,-0.061655626,-0.0448935,-0.017678367,0.055011623,0.048634738,-0.051149443,0.0068188296,-0.02167203,-0.02409584,0.05544324,0.04448999,0.082297705,-0.018312184,0.0024959426,-0.052571736,0.01129615,-0.06984124,0.04527628,-0.09231334,-0.068271644,0.0842374,-0.0223486,-0.0052722283,0.08208872,0.021710588,0.040912434,0.009792169,0.038164403,-0.12329553,-0.005115339,-0.0045371046,-0.09095319,-0.035438985,0.06308009,0.065287314,-0.016741786,0.047467545,0.060039397,0.010579892,0.046605933,0.004132223,-0.037118603,-0.07411021,-0.0575159,0.10142222,-0.029007751,0.06318401,0.13743497,0.0038476838,0.04121414,0.0039660097,-0.09217065,0.094744295,0.06809214,-0.09745651,0.040231805,0.059539236,-0.044837397,-0.07706681,0.050437395,-0.048039597,-0.03736346,-0.02927312,-0.02782722,-0.030624203,-0.06988457,0.045101292,-0.090647005,0.042067725,0.095685914,-0.037417945,0.04650004,-0.016553976,0.027431292,-0.013788172,0.056248564,0.067640305,-4.353575e-08,-0.054852005,-0.06372001,0.08066396,-0.0780159,-0.009226898,0.095792875,-0.023008475,-0.033438083,0.03217324,-0.066300616,0.015931876,0.06663279,0.016031027,0.018211847,0.008820196,0.034204036,-0.11976846,-0.06312571,0.0443798,-0.03323477,-0.0067049167,0.022557396,-0.06482747,0.07727416,-0.0058823624,-0.016726976,0.04561608,0.03880226,-0.02626568,-0.01624233,0.012778109,0.019929675,-0.07455977,-0.0689034,-0.039782174,-0.03842567,-0.028213158,-0.061416212,0.014389302,0.019516515,0.07295181,-0.014261754,-0.045754723,0.03173642,-0.02515349,0.01301692,0.0063118576,0.035408717,-0.07731436,0.04701805,0.10302321,-0.017667275,-0.07634435,-0.008302496,-0.038310226,0.010414401,-0.0195451,-0.08382105,-0.02164611,0.028971767,0.016884435,-0.0014349436,0.1455276,-0.004932157 +1.1.1.334,"The enzyme from the plant Erythroxylum coca catalyses the penultimate step in the biosynthesis of cocaine. In vivo the reaction proceeds in the opposite direction. With NADH instead of NADPH the reaction rate is reduced to 14%. The enzyme also reduces tropinone, nortropinone and 6-hydroxytropinone but with lower reaction rates.",384,1.0,-0.010813965,0.050345074,-0.07225214,0.008179049,0.017469479,0.052667018,-0.08343429,0.053389166,-0.0082972385,-0.016789742,0.015235808,0.020535601,-0.045154355,-0.012643949,0.02727806,0.046975337,-0.06568066,0.008538415,-0.018684924,-0.051392954,0.08507614,-0.065495126,0.05861879,0.0077336244,0.0046049813,0.039135516,-0.037668426,-0.009039148,0.018010644,-0.098709375,-0.09721347,0.054689918,0.010741537,-0.044193637,-0.04617424,-0.013940553,-0.07142838,0.008335713,0.09194558,0.059683517,-0.020996222,0.011726717,-0.06323006,0.028618453,-0.06340718,-0.074413314,0.015149924,0.079614155,0.01702116,-0.09222065,0.0067518596,0.03902579,0.0025287773,-0.014036984,0.0044855885,0.0040957793,0.025753224,-0.009438778,0.01985898,-0.004126382,0.08701674,0.057535194,-0.07702231,0.004615595,0.07187447,-0.03546403,0.027539723,-0.08149869,0.030655479,0.010183128,-0.083676845,-0.07578758,-0.003624122,0.025794782,-0.029228669,0.053880453,-0.02364434,0.034016598,-0.034175947,0.055887956,0.014411904,-0.0020559381,-0.03564291,0.07848178,0.05466551,0.029695181,-0.04603655,0.03863131,-0.04530201,0.0014803594,0.038636565,-0.018867826,-0.06798231,-0.011025162,-0.11491834,-0.003577613,0.028035432,-0.027691312,0.00032360616,0.009349332,0.07256055,0.09357957,-0.042639367,-0.11266684,0.005210626,0.02748441,0.022841046,0.07529018,0.014924176,0.022932671,-0.03383833,-0.015560733,0.035953354,0.08983734,-0.052273102,0.09067922,0.0019668983,0.014008481,-0.099190354,-0.01649975,0.041559916,0.013997419,-0.020408407,0.01809816,-0.0033833242,-0.041860558,-0.08692477,4.5758524e-33,0.054345515,0.08363803,-0.089139454,-0.04936585,0.09817352,0.07516718,-0.021704135,0.04854336,0.03237279,0.057431344,-0.056962367,-0.10299552,0.020361662,0.02773111,-0.047234174,-0.04373183,-0.05718208,-0.028575059,0.050019603,-0.01815481,-0.019594893,0.0019463584,-0.07743061,0.023154024,-0.034508705,0.06708339,-0.10522055,0.07219418,-0.0038413852,-0.021905124,0.02732678,-0.025005491,-0.04692899,-0.014675108,0.030209208,-0.08312728,0.026977405,-0.028748065,-0.03652086,0.0364177,-0.07739234,0.11748671,0.016706128,-0.026463801,0.03358828,-0.049823757,-0.056968827,0.0757211,0.10482692,0.03272483,0.03980327,-0.037152562,0.10553351,-0.057963498,-0.009039759,0.018114371,-0.027069384,-0.031190895,-0.005621469,0.097948335,0.06345575,0.026420372,-0.025503507,0.012835454,-0.039864477,0.046623975,-0.031411324,-0.07422686,-0.020063456,0.08039996,-0.06179164,0.019950278,0.053138968,0.012100819,0.02638223,0.0061585587,-0.008857308,-0.005985907,0.047217846,-0.027084513,-0.032709684,-0.012603259,-0.020745438,-0.040225945,0.050734382,0.05598503,0.046300948,-0.046478655,0.01466861,0.108975075,-0.035483114,-0.08274618,-0.0486732,-0.04441989,0.06694193,-4.493122e-33,0.04332362,-0.01668693,0.0264507,-0.10780082,0.01547203,0.059646267,0.053099047,-0.05076283,0.025302889,-0.037391674,0.027900869,0.0027394807,0.07576232,0.010210853,0.06392363,0.023540495,0.016005402,0.07564926,-0.047507692,0.001373022,-0.07583431,0.07127855,-0.05942759,-0.0048208092,0.04484069,-0.05380338,-0.0426493,0.06625723,0.04566898,0.014294313,0.015105463,0.025835441,-0.090364955,-0.025181033,-0.0458268,0.122699514,-0.05921981,0.024681134,0.0252536,0.019344827,0.028543957,-0.015136807,-0.05428447,0.00061516353,0.07732869,-0.004271696,-0.13620162,-0.017610641,0.00858494,-0.013843416,0.07323954,0.047065295,0.0027551837,0.016493328,0.05122787,-0.016429113,0.034859102,-0.1168796,-0.0072177565,-0.00601929,-0.034946207,0.011855162,-0.049333844,-0.0019144733,0.030315923,-0.028848069,0.011828175,0.15363662,0.09416943,0.014755207,0.10304249,0.05921947,0.030813007,0.086255334,-0.028508326,-0.04080062,-0.09073312,-0.026222907,-0.026490591,-0.013817791,-0.02190999,0.043314934,-0.020235224,-0.10075758,-0.06254642,-0.014650246,-0.0036950514,0.06895116,0.050824087,0.036155675,0.054602094,-0.04082251,-0.036702666,0.016268607,0.035264112,-3.646008e-08,0.008983109,-0.07468261,0.07301605,0.03895109,0.016116492,0.08602418,0.058925718,0.026912143,0.016241627,-0.051312674,0.0071607428,0.11472702,0.033821456,0.046191603,0.0052907583,-0.015631326,-0.024623653,0.05421551,0.013061672,-0.00013823193,-0.042594444,-0.0054794424,-0.06595419,0.010600172,0.064867064,-0.07342442,0.028025545,0.004517674,-0.028025867,0.010240903,0.0065286607,-0.038730677,-0.00954482,-0.03170574,-0.016379632,-0.012873122,0.0124643585,-0.032009903,-0.023505172,-0.020059207,-0.012154748,-0.08618215,-0.10977719,0.024960555,-0.0027504736,-0.077891946,0.004473578,-0.033426486,0.03394789,-0.047023404,0.06945745,-0.028315667,0.018988673,-0.07756189,-0.008004016,-0.0019152197,-0.033595536,0.010625067,-0.06075073,-0.047260895,-0.030424928,0.057692625,0.17763734,-0.095228724 +1.1.3.43,"Contains FAD. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Works in combination with EC 2.6.1.93, neamine transaminase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase.",384,0.99999994,-0.012275374,-0.037401706,-0.083013736,-0.08203275,0.04212685,0.019051328,-0.09910681,0.09559495,0.06826368,0.00032675054,0.0030434807,-0.009864773,0.047633577,0.07233621,-0.041997433,0.0056033223,-0.08090416,0.005870172,0.008169025,-0.040279984,0.02227215,0.060244616,0.03970326,-0.03285445,0.04164151,0.024800789,0.019621775,0.040973734,-0.022391122,-0.0828514,0.09353037,-0.026292436,0.034855008,-0.041917223,0.031966012,0.09393879,-0.04193734,-0.056876823,0.11242148,0.056153387,-0.06132465,-0.00878107,0.0100048585,-0.024702378,0.042920172,-0.028130565,0.05356072,0.053446542,0.030845612,0.015217615,-0.004341823,-0.043027963,-0.008747983,0.037118725,0.06480201,0.08765061,-0.06280602,-0.027885962,-0.031131027,-0.022053495,0.0713191,0.021525433,0.026606334,-0.026628045,-0.07694714,-0.032242376,-0.0144379195,-0.081197426,0.062962376,-0.015502629,-0.09427529,-0.09751655,0.055681936,0.06626338,-0.0021491125,0.0008429809,-0.031682994,-0.057522062,-0.04164272,-0.054666143,-0.021413997,-0.0613103,0.012089171,0.11621857,0.097253524,-0.0062288875,0.0756873,-0.028943112,0.022850322,0.062283233,0.08776932,-0.02750742,0.05227162,-0.07759228,-0.073756926,-0.035083365,-0.014155831,0.064598605,0.03747982,-0.029844742,-0.013779691,0.05813455,-0.06912838,-0.043446943,0.0065855044,-0.024022307,0.028841475,0.115090765,-0.002586553,-0.07986527,-0.023409873,-0.025313644,-0.01846863,-0.014228893,-0.00048117025,0.09742171,0.1113513,-0.07439118,-0.048089325,0.011151928,0.0054851,0.034434993,0.033545017,0.06513549,-0.0023058988,0.03399944,-0.0928798,3.7345015e-33,0.0057660784,0.070062496,0.0010131944,-0.030081885,0.0046530943,0.04826798,-0.13478255,0.009313292,0.037791055,-0.06946041,-0.103606686,-0.023776632,0.04681624,0.012366599,0.0041090576,-0.050318766,-0.027990218,0.0031016713,0.007148155,-0.03441984,0.059801448,0.029049836,-0.008342143,-0.003782437,0.033280276,0.038907543,0.022683166,0.032835733,0.13320686,-0.01198311,-0.07028988,-0.03716218,-0.07343617,-0.015090934,-0.038387235,0.040290255,-0.08484309,-0.024461158,0.05799902,0.08422734,-0.017357891,0.037694283,-0.03291777,-0.03164472,0.053169295,-0.044626176,-0.030497067,0.10359612,0.04420451,-0.014854605,0.03998269,-0.061990526,0.078326665,-0.048953623,-0.030191302,-0.015414299,-0.054960024,0.03167586,0.052029606,0.07334814,0.03422991,-0.0152897155,-0.012352004,0.015680702,0.025920046,0.016867232,0.0031649587,-0.05017155,-0.050359305,0.041355558,-0.116406515,0.037748773,0.07397898,0.028356355,0.019716712,-0.03711113,-0.1013641,-0.0140128825,0.03754507,0.012907849,-0.04358395,-0.061231844,-0.031150391,-0.0061152675,0.034318727,0.03486401,0.0024570923,-0.071899675,0.017017504,0.077025495,-0.013934146,-0.13310924,-0.112824574,0.0093733575,0.02596918,-3.9247262e-33,0.050502405,-0.08226821,0.029159259,-0.042096447,0.012236676,0.0649564,0.008779538,-0.04135411,0.053064484,-0.04191315,0.08891675,-0.017433038,-0.02524446,-0.09438688,-0.046229783,-0.0502836,-0.0290826,0.04464707,-0.0021949005,0.05270948,-0.00071939285,0.03502199,-0.020583343,0.002922537,0.05246951,0.078462034,-0.017690856,0.040268004,0.038537115,0.062933125,-0.042892504,-0.020157278,-0.05972744,-0.048121393,-0.02801054,0.09951911,-0.08598671,0.055963516,0.00037530603,-0.06807888,0.036423784,0.0055381795,-0.015544606,0.096001096,0.0411194,0.058999125,-0.089729525,0.028841157,-0.0032676782,-0.054405157,0.039489847,-0.026019283,0.03001379,0.029872237,0.034385957,-0.007067741,0.0033138788,-0.013352585,0.00053937896,0.0034910275,-0.059306648,-0.02562818,0.03226424,-0.04078742,0.047056515,-0.026860937,-0.05517738,0.117723845,0.025139123,0.008327073,0.05408929,0.0012956926,0.019363131,0.024849316,0.0041051316,-0.011957811,-0.055789355,-0.033643447,0.018901188,-0.0007654802,-0.0028487118,-0.005451322,0.0033119202,-0.027375057,0.0118225645,0.029476956,0.06516049,0.07222281,-0.020401975,0.011359746,-0.015519952,0.03657943,0.0044544106,0.018800594,0.05595361,-4.2345604e-08,0.061532754,-0.056821566,0.048076395,-0.042419683,0.061534535,0.011157006,-0.070327684,-0.018498072,-0.006444846,-0.05398398,-0.01817527,0.10541163,0.037010286,-0.038305808,-0.044927035,0.03714444,-0.036845744,0.04533461,0.0040069385,-0.026821697,-0.11998301,0.0020831118,-0.11164635,0.017989682,0.073620796,-0.006020434,-0.002164285,-0.020394899,-0.017141944,-0.043171287,0.05427209,-0.025945485,0.0029716264,0.009810412,-0.047955904,0.010057236,-0.04565541,-0.036165632,-0.0060708853,-0.028407924,0.057773646,-0.037898906,-0.10139049,0.016154643,-0.023408074,-0.008416053,0.0065846047,-0.021410447,-0.06064106,-0.019364346,0.06971092,-0.016448563,0.012298524,-0.033207793,-0.08819912,0.018119382,-0.025919497,-0.10484142,-0.040604003,-0.063084714,0.0053850575,-0.03772591,0.21346053,-0.019748848 +1.1.3.44,"Contains FAD. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 2.6.1.95, neomycin C transaminase, to replace the 6'''-hydroxy group of 6'''-hydroxyneomycin C with an amino group. +Also catalyses EC 1.1.3.43, paromamine 6'-oxidase.",384,1.0,-0.03938243,-0.025556121,-0.072278544,-0.11006001,0.04967424,0.0117124105,-0.053187933,0.082798354,0.04759484,-0.030240282,-0.011318993,-0.0035661706,0.046964005,0.03349378,-0.014369679,0.03767013,-0.073559895,0.032109972,0.010175167,-0.027784273,-0.0033484243,0.019393172,0.1012109,-0.010474384,0.047420572,0.016203178,0.024012819,0.055050448,-0.010676287,-0.05075005,0.11153761,-0.00035523687,0.0021316474,-0.01741051,0.016950395,0.0826638,-0.013791206,-0.02792942,0.0990599,0.03538048,-0.035617474,-0.01553472,0.027456649,-0.047835167,0.06697819,-0.018036144,-0.026558835,0.024241675,-0.003946076,0.025691072,-0.011206439,-0.068581484,-0.027324542,0.056596935,0.06338541,0.09424999,-0.046290282,-0.07808697,-0.0047892993,-7.9835445e-05,0.07499716,0.007862793,-0.009690242,0.016171701,-0.07148237,-0.044396177,-0.021532476,-0.059935607,0.037494313,-0.040263973,-0.09973798,-0.09330181,0.0061840545,0.05259991,-0.0091453595,0.0011041233,-0.010840664,-0.0861129,-0.026111687,-0.0724209,-0.008801505,-0.012664545,0.05105419,0.110629596,0.06739581,-0.0130347,0.09489045,-0.014500273,-0.008239919,0.0517298,0.091443956,-0.02693684,0.014961732,-0.068746515,-0.07614799,-0.013643068,0.04519394,0.046813596,0.052483916,-0.016458793,0.011920698,0.030861175,-0.07330841,-0.06591708,-0.000792127,-0.008912046,0.010440378,0.135079,-0.014532227,-0.04670973,-0.05561831,-0.054173753,-0.03007268,-0.03154765,-0.055901542,0.08831196,0.102048144,-0.0720039,-0.03791983,-0.007347924,-0.007470231,0.06550396,0.01478055,0.06592823,0.010066754,0.02259018,-0.083923936,2.004988e-33,0.0030478528,0.06870303,-0.02668736,-0.015416582,0.007874551,0.046700843,-0.12096976,-0.02991141,0.030148681,-0.047795713,-0.11247325,-0.00773334,0.014580014,0.051922947,-0.012781996,-0.043871023,-0.011478158,-0.017125629,0.014427999,-0.071852215,0.05298358,0.046005465,0.003745508,-0.009168837,0.03873652,0.039322432,-0.0022614475,0.061949905,0.10296603,-0.002929253,-0.085481,-0.027018085,-0.07400916,-0.0030444143,-0.049348954,0.0541131,-0.07057312,-0.06887739,0.051434156,0.07843359,0.0115552405,0.047910634,-0.002004844,-0.015022995,0.033202387,-0.051921826,-0.055280622,0.12212056,0.0631991,-0.004438453,0.031838037,-0.046144616,0.036602154,-0.010866078,-0.04200829,-0.010281674,-0.07848318,0.019992955,0.047647472,0.061902534,0.05423344,0.014360313,0.008130474,0.05348756,0.0389082,0.013152745,0.015139054,-0.025378536,-0.070332795,0.04956382,-0.11885411,0.037419494,0.105329156,0.01043182,0.073041916,-0.054455068,-0.04503141,-0.051542945,-0.0043593836,0.014113129,-0.024003634,-0.048700184,-0.006030731,-0.002962261,0.02661233,0.016386002,-0.0075837756,-0.06357887,0.012297785,0.04237945,-0.030443002,-0.14518224,-0.10388681,0.040885035,0.0012626586,-3.15603e-33,0.030140623,-0.05501883,0.093132555,-0.036258824,-0.0017124694,0.036733937,0.016138596,-0.03820223,0.05849971,-0.018609557,0.07733186,-0.014329016,-0.012898143,-0.07537564,-0.037249163,-0.05159232,-0.027171956,0.033586394,0.0012074434,0.05630633,-0.010478231,0.019057449,-0.050854094,0.04340917,0.057798676,0.04951063,-0.03285622,0.029929709,0.035504438,0.056804392,-0.026419144,-0.035100218,-0.07624413,-0.03548589,-0.018374631,0.08613214,-0.03659269,0.037031125,-0.042446323,-0.033899814,0.010414444,-0.032629676,-0.047270223,0.107530296,0.03628953,0.05727804,-0.07156383,0.03688498,0.0049165995,-0.05340215,0.042525377,-0.009936653,0.04328966,0.03131713,0.0542222,-0.023868885,0.027796376,-0.012560507,-0.01811695,-0.01945802,-0.032425128,-0.008078367,0.02593902,-0.057014085,0.082816094,0.013918811,-0.06415042,0.09704514,0.03376209,0.03491328,0.10213823,0.04648708,-0.020173315,-0.011675807,0.030532451,0.03655021,-0.050124507,-0.048797052,-0.0021367052,0.040572926,0.045054633,0.018075576,0.0050799055,-0.015323505,-0.027319008,0.03893887,0.054927766,0.08025711,-0.05269413,-0.03363015,0.010524688,0.04417234,0.006681895,0.004973813,0.02529678,-3.5447915e-08,0.06591659,-0.056477044,0.03706937,-0.08433879,0.03615616,0.039156318,-0.07058759,-0.024462225,-0.020453155,-0.045417678,-0.045165934,0.12872633,0.022548137,-0.050945442,-0.046205603,-0.012119814,-0.016451627,0.07859709,-0.017837418,-0.011712644,-0.1087087,0.038428936,-0.09518868,-0.007756939,0.047341112,-0.035201535,0.010839277,-0.016312148,-0.030234942,-0.03802416,0.07967183,-0.011974399,-0.02188612,0.009873654,-0.043054923,0.031788193,-0.01543446,-0.046982814,-0.020057287,-0.008605509,0.07099316,-0.05768443,-0.09973888,-0.002109429,-0.047253765,-0.012583944,-0.0062093446,-0.04650913,-0.06582661,-0.003808391,0.070030235,-0.009518247,-0.017012624,-0.06180725,-0.08976191,-0.016860979,-0.057122674,-0.10854055,-0.009510821,-0.07553209,-0.009724692,-0.039517265,0.21321519,0.008938812 +1.1.98.3,"The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.1.333, decaprenylphospho-D-erythro-pentofuranosid-2-ulose 2-reductase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.",384,1.0,-0.046827625,-0.015263928,-0.069981456,-0.049072336,-0.0049087834,-0.017383551,-0.010604837,0.0817794,0.020476282,0.04164368,-0.025255553,-0.025543405,0.06033522,-0.012814412,-0.05267176,0.03229439,-0.023650931,0.06040909,-0.0052872295,-0.002282557,0.049870413,0.025295053,-0.00500542,-0.08532745,0.11378692,0.011359229,0.02877883,-0.007401608,-0.08226652,-0.09116602,0.035684112,-0.08678654,0.082278825,-0.054245505,0.14440039,0.0955631,-0.022813048,-0.08216081,0.0820771,0.006909521,0.09478312,-0.023404215,0.07052471,-0.04743707,-0.010406869,0.03576095,-0.036013268,0.07514719,0.03649992,-0.033227257,-0.042447332,-0.02980975,-0.067591794,-0.028371254,0.018715493,0.028695084,0.029953687,-0.040793907,-0.0032136245,-0.0045011383,0.04314643,-0.0027077894,0.024568582,0.02222072,-0.062403053,-0.040325884,0.02443197,-0.008785919,0.034888845,0.005942061,-0.037669122,0.025191136,-0.039673038,0.07363845,0.05247701,-0.043646522,-0.008392625,-0.02330762,-0.014156355,0.043008022,-0.056595672,-0.056621414,-0.0034750833,-0.07324769,-0.003701816,-0.02868819,0.098445766,0.05572697,0.012673582,0.103039235,0.05423102,-0.034377653,0.039329626,-0.072310634,-0.018281963,-0.036984425,0.03428803,0.052999564,0.020819642,-0.06627648,-0.011000587,-0.062085323,0.06545319,-0.06845513,-0.0688752,-0.013805106,-0.087283835,0.06436991,0.0482726,-0.0076197134,-0.051771715,0.010619398,-0.011787968,0.016632996,-0.010492016,0.097789265,0.052905265,-0.11520174,-0.06486769,0.01717147,0.0011516982,-0.055146705,0.05127269,0.018157946,-0.12337937,0.04604767,-0.10855466,3.7803854e-33,-0.035088584,-0.02940227,-0.0042115645,-0.028844258,-0.0007535395,-0.032822248,-0.10531565,0.0019171828,-0.07462483,-0.04746816,-0.091987364,-0.065080166,0.054396402,0.10157348,-0.103017986,0.03741182,0.036136296,-0.009799977,0.06947676,0.030893015,0.032323793,0.030440116,0.03339239,0.029496104,0.006813106,0.028050499,0.0027503094,-0.0019697053,0.07369949,-0.00917316,0.020871803,-0.05666707,-0.024159767,-0.01986794,0.049028646,0.013010383,-0.076327935,-0.05518459,0.013814543,0.022871144,0.045467146,-0.004695904,0.036253817,0.0137927625,0.101145715,0.039432615,-0.004249218,0.009461743,-0.01530224,0.043321095,0.018963333,0.021630714,0.053274725,-0.04876116,-0.014114416,-0.045046046,-0.043893095,0.021752141,-0.0012785143,0.011001568,0.019387145,0.10540395,-0.015414417,0.058325022,-0.050918892,-0.027216485,-0.014038758,0.03463391,-0.021510702,0.036521316,0.005063947,-0.07035171,0.010403001,0.015808254,0.09505759,-0.01722874,-0.061008237,-0.02197766,-0.006758867,-0.051840886,0.027745852,0.08337191,-0.108419456,-0.059728526,-0.04852249,-0.0046638073,-0.03016164,0.001964024,-0.022030849,0.004070058,0.021030804,-0.086115316,-0.054554947,0.05227022,-0.006612196,-6.507769e-33,0.10648713,-0.1699176,0.10450327,-0.0395071,0.020860502,-0.01809683,0.09819417,0.042127173,0.07084745,0.037565827,0.08063995,-0.011664941,0.005161523,-0.06976283,0.027484676,-0.012051805,0.046729777,0.02608193,-0.055691954,-0.029521009,-0.052896548,0.07079391,0.030181212,-0.06625396,-0.0121731255,-0.0042942576,-0.036675576,0.064699024,0.019641604,0.05331646,-0.030557709,0.005922498,-0.06712785,-0.018955935,-0.09305784,0.036698047,-0.09238347,-0.07959645,0.04738158,-0.025881775,0.02573525,0.089785375,-0.007953568,0.023352211,0.010891592,0.00719501,-0.11649699,0.022881836,-0.0070882174,-0.07745735,-0.05518021,0.051731918,0.08088641,-0.02125779,0.023425363,0.040504463,0.045385517,0.047106367,-0.017204467,-0.01639703,-0.08686938,-0.061600935,0.08573659,-0.0172395,0.05478488,0.083678596,0.035493676,0.04033297,-0.004379873,-0.059945587,0.08239398,0.04743618,-0.08270851,0.058056753,0.011018894,-0.0235083,-0.080089554,0.043446068,-0.050655603,-0.027835326,-0.008081743,-0.028971253,-0.043176703,-0.04881834,0.05652941,-0.07635468,0.04422334,0.09323235,-0.04652498,0.038280953,-0.007697468,0.013931928,-0.026442787,0.060350858,0.0315581,-4.580085e-08,-0.026702687,-0.03504615,0.059327364,-0.08020617,0.02343013,0.06084862,-0.042701054,-0.021776298,0.02548982,-0.01932475,0.022822829,0.04196989,0.011350822,0.005361328,0.0050252024,0.046208736,-0.09323666,-0.06974779,0.045724895,-0.026218299,-0.027303329,0.015983466,-0.10557825,0.07089062,0.0042736875,-0.014473089,0.04256376,0.06421477,-0.0026560328,-0.008300019,0.0111227315,0.003633457,-0.045708176,-0.055217456,-0.056731705,-0.048950564,-0.051357187,-0.07797662,-0.009192398,0.024069391,0.08389897,0.009899329,-0.029958444,0.023822812,-0.03282275,0.01620815,0.0025202816,0.023879595,-0.059436206,0.059863735,0.07504587,-0.009141451,-0.09016789,-0.01199272,-0.022195404,0.025707008,-0.008932684,-0.055574,-0.018796815,0.03814107,0.03270778,-0.028053299,0.11649737,-0.011712613 +1.1.99.38,"Involved in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family. The enzyme from Bacillus circulans was shown to be a radical S-adenosyl-L-methionine (SAM) enzyme. cf. EC 1.1.1.329, 2-deoxy-scyllo-inosamine dehydrogenase.",384,1.0,-0.07893341,-0.021716919,-0.12084141,-0.020576175,-0.003307935,0.0510012,-0.17295635,0.0633446,0.086618535,0.01698268,0.030448832,-0.008629023,0.118404806,0.061917637,-0.0691926,0.02406742,-0.095661215,-0.010789134,0.028455608,-0.015040092,0.05968001,0.09594705,-0.03423386,-0.011513514,0.06979462,0.012667484,0.04213061,0.0038132332,-0.03536796,-0.0047252118,0.050586186,-0.056225255,0.06402221,-0.043324392,0.037780125,0.0772616,0.0028485686,0.07173755,0.18907563,0.02886334,-0.09760543,0.06525001,-0.029999489,-0.025326824,-0.04769361,-0.054781336,0.017078428,0.06967646,0.040416453,0.009928554,-0.071849555,0.009102732,-0.03699628,-0.0040610074,0.08064818,0.022294672,-0.07876589,-0.061154354,-0.057917338,-0.04172878,0.06313876,-0.049702067,0.055301476,0.01267715,-0.11465089,-0.020685613,0.04265922,-0.0512819,0.04293756,-0.07342007,-0.07214574,-0.05061484,0.057738367,0.03008889,-0.011804203,-0.0136584705,-0.038640883,0.0072265193,-0.05355853,-0.095430456,0.06960996,-0.04622819,-0.03971704,0.08106401,0.09754099,-0.00795562,0.047707003,-0.0153110735,0.028991839,0.044197142,0.020694742,-0.062177144,-0.02560194,-0.09467123,-0.023880187,-0.07146383,-0.0032468978,0.06528091,-0.019324718,-0.03633478,0.012786484,0.017176885,-0.03598547,-0.074466966,-0.0478416,-0.00821759,0.014175715,0.037334524,0.04188604,-0.0075329402,0.015928924,0.03706857,0.012067133,0.017014608,-0.025596222,0.05904214,0.08032801,-0.054280635,-0.06635522,0.02535431,0.016967906,-0.0052568247,-0.01931138,0.044143755,-0.02367452,0.029189032,-0.02636082,5.555277e-34,-0.0065356996,0.10043736,-0.005527726,-0.02079526,0.026851214,-0.046155203,-0.048786383,0.04648754,-0.032438524,-0.044574622,-0.09900366,-0.06593304,-0.00025182738,0.026170425,-0.022151751,0.011357412,0.012094642,-0.042590342,0.03516203,-0.02293897,-0.06899894,-0.0038626054,-0.08672578,0.024003543,0.030969959,0.07919298,0.018686257,0.019704813,0.088181496,-0.00573989,-0.00013322492,-0.043123253,-0.08937118,0.014862516,0.02763329,0.0037805005,-0.04384766,0.0037292948,0.031769715,0.021693926,0.02424208,0.044194616,-0.05283693,-0.019580573,0.041413885,0.032018993,-0.026224589,0.09733792,0.046577677,0.03955367,0.044703852,-0.027644623,0.11356954,-0.007867283,-0.04612892,0.042231224,-0.034327637,0.02104837,0.0048233774,0.120123036,0.017422635,-0.03759929,-0.0022877995,0.044433925,-0.0047711353,-0.046923753,-0.089104414,0.01530343,-0.009347161,0.0516624,-0.06668033,0.04514713,0.03365517,0.016934603,-0.05140356,0.0137411365,-0.05946375,0.015304921,0.07377758,-0.0036587354,0.022513533,0.036954757,-0.034422968,-0.052524157,-0.01853137,0.029321993,0.0029498402,-0.033302173,-0.04792375,0.06346097,-0.03112114,-0.12204703,-0.072737575,0.021552388,0.048027374,-3.0490735e-33,0.05273593,-0.0664363,0.067818455,-0.061739292,-0.04112415,0.11317798,0.014723672,-0.014956977,0.021044143,-0.054243833,0.06595586,-0.019054752,-0.008189562,-0.07241366,0.031401075,0.028739456,0.048282728,0.06257756,0.008866797,-0.028068293,0.039727695,0.04260369,-0.011616007,-0.041497312,0.004538191,0.058016784,0.0013653024,0.08830048,0.031076556,0.0981477,0.052221518,-0.039047666,-0.057192653,-0.05520849,-0.04634327,0.118881606,-0.06314475,-0.010739001,-0.041349083,-0.021376336,0.035314217,0.03847306,-0.025444014,0.10231571,0.054661833,0.013765007,-0.081526645,-0.055229977,0.02220057,-0.124967836,0.014527541,0.003172378,0.052376132,0.0058453158,0.017038021,0.01764861,-0.032571904,0.006193657,-0.0026063912,-0.111511014,-0.058426157,-0.039901208,-0.0567932,0.011746627,-0.030651823,-0.011616011,-0.0032562101,-0.0101312315,0.03294681,-0.06284223,0.0032744973,-0.043240994,-0.027555633,0.047717035,-0.042946115,0.025577942,-0.09311036,-0.072167516,-0.021550523,0.018698115,-0.04055679,-0.04946072,-0.031621277,0.004116433,-0.031768695,-0.042616624,0.053526547,0.057043225,0.06519472,-0.0065518245,-0.025234694,0.043363012,-0.020341175,-0.023679888,0.007400343,-3.8094285e-08,0.07911794,-0.092776045,0.0814167,0.016738635,0.020061152,0.032140862,-0.028164856,-0.030322513,-0.029023586,-0.04638077,0.016684206,0.05589956,0.0036434783,0.026536899,0.0043618903,0.038708817,-0.017194504,0.003356318,0.04866729,0.018756982,-0.12082548,0.020504065,-0.063764624,0.011898405,0.05636982,-0.0213927,0.011173705,-0.04832796,0.016865563,0.031201417,0.014691371,-0.028019153,-0.032635037,-0.03698317,-0.09612823,-0.07814975,-0.04115561,0.0186249,0.031630594,-0.002085152,0.105592504,0.00087271596,-0.08738267,0.057076532,0.009419678,0.053325225,-0.01976705,0.03981202,-0.0687169,0.0056226626,-0.0038484465,0.0114878975,-0.014180705,0.0042752614,-0.09619235,-0.004168738,-0.0038667233,-0.0643852,-0.034727436,-0.038350094,-0.05821016,0.024449222,0.14258689,0.0016604238 +1.2.1.83,The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.,384,1.0,-0.057438355,0.015993383,-0.059807982,-0.0088949185,0.025158271,0.08365456,-0.103062205,0.043876637,0.017921567,-0.011064779,-0.00080832536,-0.022484645,-0.09348949,0.010343178,-0.04297495,0.008419344,-0.064252794,0.023865221,-0.02169097,0.04476315,0.08504637,0.15040821,-0.032262042,0.013416399,-0.0035944765,0.021119285,-0.013934796,0.00885283,0.046305574,0.0536389,-0.047640387,0.0061187735,0.040138174,-0.00851884,0.058865782,0.039026543,-0.019309074,-0.0056342985,0.096569695,-0.015611918,0.039829347,0.048279352,0.0120134065,-0.05795708,-0.0012967291,0.0415008,0.034957934,-0.019760685,0.027702915,-0.036806926,-0.0108213285,-0.04459989,0.021111086,0.068188556,-0.03416975,0.011791393,-0.040817756,-0.025666147,-0.003410264,0.042285632,0.051828943,0.009093689,-0.0067279306,-0.0035775516,0.07242349,-0.035317574,0.04021164,-0.052961744,0.031783167,-0.067081705,-0.13888118,-0.05098296,0.03784426,0.011131784,0.010850279,-0.00026699898,-0.11255852,-0.028178463,0.04936158,-0.078131594,0.05678797,-0.046287663,0.010562185,0.12496525,-0.006953826,-0.05933605,0.06141893,0.037912667,0.073875494,-0.05802414,0.009306483,0.035420198,-0.022126382,-0.03024434,-0.1551095,0.04888034,0.023490824,0.043607183,0.009419589,-0.0135074295,0.024633005,0.06346134,-0.0060743284,-0.10086847,0.018612087,0.05325695,-0.034699112,0.04960331,0.06644661,0.035832457,0.0005647247,0.019730594,-0.047095984,-0.04468357,0.013568611,0.060897294,0.011993956,-0.024558173,-0.059646744,-0.008300587,-0.003763289,-0.06008391,0.044813313,0.052591443,0.04937146,-0.04920768,-0.0788386,-1.8486293e-33,-0.015931765,0.0036753432,0.00287137,-0.034574132,0.06690873,-0.027910037,-0.011284067,-0.0029176255,0.020006867,-0.03783878,-0.011729403,-0.08763682,-0.024337394,0.023561371,-0.0042597796,0.029044662,-0.033055596,-0.09142108,0.07314837,0.004804895,0.066936895,0.0028672921,-0.04966857,0.06404895,0.01305275,0.030621283,-0.020112531,0.019634012,-0.04439827,-0.035891406,0.09962187,-0.03862405,-0.14544544,-0.12209015,0.08336689,0.02790264,0.040576667,0.045269743,-0.06425529,0.0619287,0.07028078,0.017817449,0.03477745,-0.02353153,0.053483818,-0.061038733,-0.056693997,0.07513888,0.117588714,0.08161226,-0.034557562,-0.12681991,0.09280049,-0.011046492,-0.052418,0.026046382,0.02212802,0.027903631,-0.033777755,0.041584156,0.012325466,-0.007988649,-0.06507486,0.10388719,-0.0033035364,-0.029515078,-0.0033065174,-0.07435532,0.055700943,0.07530425,-0.08342754,0.0038686865,0.016256034,0.010238532,-0.03991137,-0.10762391,-0.11535911,0.06996583,-0.0076800734,0.04028285,-0.04172043,-0.0929147,-0.058552448,-0.04598844,-0.08318305,-0.020437246,0.0537082,-0.05971702,0.0119937295,-0.027597673,0.07095088,-0.06487192,-0.026495133,0.06801737,-0.04659321,1.1367993e-33,0.04327377,0.018318506,0.06649082,0.040530775,-0.0058516352,0.06893727,0.011193245,0.03569663,-0.051020827,-0.030055711,0.057531577,0.045114085,0.114812076,0.017653728,0.03382002,0.10282666,-0.006823432,-0.019039687,0.01250721,0.0068614176,-0.043242592,0.08061069,-0.07260786,0.012922342,0.015839763,0.0065044137,0.019890582,0.10094938,0.055204995,0.008675472,-0.011582173,0.0809659,-0.053089317,-0.06746119,-0.023250928,0.021365546,-0.0051040673,-0.023618082,-0.020332657,-0.007760231,0.07111568,0.0010418452,-0.057953283,0.042951684,-0.010092348,0.033370543,-0.046794154,0.016410029,0.01330547,-0.021835024,0.07857054,0.021778055,-0.05437007,0.05617871,0.04507825,0.027875232,-0.08017249,0.030713376,-0.04789614,-0.032089207,-0.021758515,-0.04469546,-0.05063644,-0.020661205,0.041004535,0.07270665,-0.011006622,0.06263782,0.023814416,-0.047495753,0.036331613,0.027873812,0.06257299,0.010085959,-0.12246943,-0.04939999,-0.025111545,-0.0169202,0.02353217,-0.009143297,0.036135525,0.015636824,-0.01045727,-0.052753616,0.0254263,-0.022949055,0.0033116685,0.08413458,-0.026192613,0.008777982,0.017790712,-0.08221895,-0.04390387,-0.0031588753,0.0011957384,-2.5756629e-08,0.03689724,-0.090055004,0.06354845,-0.02313463,0.06472501,0.031364817,0.07174038,0.046503823,-0.016494427,0.008454478,-0.031840347,0.06274053,-0.04104797,0.03885965,0.005842888,0.020334462,-0.08459659,0.06516884,-0.056002405,0.04015254,-0.06517832,-0.024760049,-0.06443765,0.0050876294,0.042544536,-0.012541091,0.03322301,0.005132141,0.022927906,-0.019137636,-0.02506453,0.0031847474,0.048256725,-0.03240752,-0.15426293,0.018586425,0.014897309,-0.057123255,-0.035595246,0.011069732,0.029916946,-0.04549795,-0.13597059,-0.026580706,2.1440672e-05,-0.026785873,-0.03193021,0.061104625,0.0004905754,-0.033173133,0.027979309,-0.019475218,0.013621008,-0.027365632,-0.123443596,-0.02886841,0.0073493375,0.005789071,-0.010391172,0.008835281,0.040456377,0.011266257,0.13343145,-0.029864749 +1.2.1.84,"The enzyme has a wide distribution and is found in bacteria, plants, fungi, and animals. The alcohol is formed by a four-electron reduction of fatty acyl-CoA. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. Enzymes from different sources vary in their chain-length preference. cf. EC 1.2.1.108, alcohol-forming fatty acyl-CoA reductase (NADH).",384,0.99999994,0.0037525375,-0.015628736,-0.083183266,0.046694208,0.0513553,0.09187148,-0.14084437,-0.034227606,0.0726889,0.0064298385,0.07673071,-0.045669526,-0.08585522,0.009063292,-0.033874355,0.010636957,-0.03999261,-0.07547912,0.009061489,-0.066863075,0.05811569,0.018800402,0.017807959,-0.006981471,0.08650724,-0.075147174,0.018377483,-0.037514474,0.014541087,-0.06603904,0.05050683,-0.016827,0.021501962,-0.08015868,0.03868461,-0.016072512,-0.014323228,-0.012797249,0.07537097,0.045926735,0.020777546,-0.02846242,-0.024033405,0.013393151,-0.06250292,0.026057627,-0.012136421,0.053965688,0.015475295,-0.012570366,-0.0020180754,-0.041245054,-0.052344546,0.054776084,0.07062759,-0.0801864,0.030082647,0.007112135,-0.055098765,0.047284573,0.08705155,0.0010141474,-0.052868757,0.035136655,-0.032764,-0.047316182,0.03434927,-0.02978928,0.020041753,-0.09188264,-0.029808318,-0.08720468,0.023305118,0.021478163,0.022846282,-0.04627285,-0.009948727,-0.038906734,0.025964165,0.039631713,0.02887741,0.032332584,0.0243994,0.06477916,0.028184136,-0.02864528,0.025142299,-0.009431055,-0.050329234,-0.0039408426,-0.027772395,-0.02572005,-0.07444381,-0.089148626,-0.06179643,0.085605934,0.06846467,0.010299555,0.08655756,-0.050941657,0.009859372,0.05685986,0.00083780376,-0.09948206,-0.068778746,0.04838354,-0.046553656,0.110131115,0.009186442,0.052737538,0.013049549,0.038673032,0.01255386,0.0109875845,0.018960102,0.06545269,0.017218065,-0.069099285,-0.12053591,-0.0019219104,-0.061320323,0.014845927,0.11594467,0.08956025,0.008768344,0.059032567,-0.09107296,-2.8124775e-33,0.037343122,-0.015217344,-0.061540384,-0.051296715,0.06976109,-0.05031522,-0.016264524,0.07911982,-0.029511748,2.2029726e-05,-0.0006048081,-0.062993586,0.03930018,0.043422956,0.0051867627,-0.03187814,0.06060852,-0.048341963,0.012540078,0.03834282,-0.057983097,0.024573244,-0.0018147723,0.039908234,-0.013241546,0.016144315,-0.02526514,0.040704217,-0.032586306,-0.007573435,-0.025191812,-0.04790785,-0.076961026,-0.02231661,0.061180387,0.0010368207,-0.07237645,-0.0032952826,-0.0522491,0.02200947,0.07900534,0.041160814,0.058631636,-0.054196816,0.034963626,-0.019937113,-0.11099305,0.0465654,0.076537974,0.03536443,0.06858787,0.0053077936,0.13579819,-0.0065579526,-0.09568046,0.09911692,-0.04622409,-0.024003964,0.010005852,0.005068513,-0.003879844,0.05959931,-0.07041264,0.047469337,-0.02538672,0.02129872,-0.032522384,-0.0773581,-0.049411505,0.04445504,-0.01970787,0.018234862,0.018317807,-0.021336414,0.021294039,0.0010711676,-0.06517165,0.003003595,0.04353546,-0.041763093,-0.01302281,0.017934939,0.010343213,-0.043094944,-0.0036182734,-0.049389053,-0.04907452,-0.041490827,0.033969324,0.0053185984,-0.0072775153,-0.05844369,-0.026370296,-0.020524144,0.084557734,-1.975478e-34,0.10824218,-0.10097888,0.020448964,-0.16352867,-0.019114042,0.09043185,0.004570594,0.011065021,0.04372619,0.004552059,0.0303608,0.036912844,-0.050618555,-0.02247833,0.05641847,0.0035971396,0.0040852223,0.062169082,0.026244797,-0.040954683,-0.0022125847,0.038456388,0.04240642,-0.024149237,0.06991739,-0.038708884,-0.02726157,0.046697635,0.079714395,0.0075684707,-0.044164687,-0.024943922,-0.012378056,-0.040889245,-0.052056387,0.022348464,-0.12990756,0.030870767,0.0028596576,0.09025507,0.037262734,0.03526829,-0.05340426,0.023917727,0.10057712,0.022635441,-0.11670241,0.000610311,0.036702164,-0.081994034,0.081518546,0.0017950637,0.018418133,0.028146366,0.022804677,0.08381443,-0.014386802,-0.007687017,0.040413357,-0.059733856,-0.10254891,-0.016348055,-0.018973138,0.034531314,0.012516075,-0.0028836918,-0.027492536,0.042353977,-0.027166657,-0.023840772,0.07137378,0.057828356,-0.04216291,0.08045898,-0.07064568,-0.05760249,-0.07073718,-0.043136988,-0.015892651,-0.0006098122,0.018862529,0.041107945,-0.0031460887,-0.050820194,-0.039934676,-0.090179615,0.04822842,0.019794008,0.00062827126,0.029181793,0.0204492,0.05418561,-0.019321496,0.033327937,0.017828712,-3.764611e-08,0.014716586,-0.0022829832,0.093054704,0.02146117,0.023330016,0.04713411,0.049835283,0.01271957,0.022005709,-0.01579684,-0.06798601,0.08209726,0.015651006,0.031702302,0.010571928,0.0033899648,-0.07297008,-0.012203918,-0.02922241,-0.042726964,-0.04756324,-0.0030625984,-0.040077075,0.0734577,-0.0584774,-0.053964123,-0.0050119353,-0.0028628842,-0.0357668,-0.007296414,-0.010543516,0.08345748,0.008213709,-0.016532129,-0.032301683,-0.007443292,-0.019118559,-0.0651631,-0.048532978,0.102974005,0.0050636614,-0.047532864,-0.0306539,-0.019779379,0.02123495,-0.007475781,0.009895894,-0.01523946,0.00990019,0.058891512,0.064437725,0.04139053,-0.02426292,-0.04414644,-0.100853145,-0.0040059616,-0.05159698,-0.083436966,0.005099056,-0.09799399,0.062091157,0.037857693,0.2320886,0.024934847 +1.3.1.93,"This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase.",384,0.9999999,-0.07820486,-0.09468357,-0.07402595,-0.019907972,0.08271103,-0.008521928,-0.13686755,-0.007895805,0.020271726,-0.07234787,0.102424204,-0.059373178,-0.06728437,-0.0044570942,-0.0052808467,-0.0010089406,-0.086945996,0.022006907,-0.04253902,-0.09219818,0.07526551,0.06231945,-0.01966371,0.054016083,0.050938834,-0.05639277,0.07745888,-0.036308616,-0.036235828,-0.12142412,0.02217172,0.0015722638,0.0903725,-0.0577149,0.081545144,0.0672028,0.015615466,-0.09833016,0.021783287,-0.024462866,0.09948681,-0.058768675,0.06022521,-0.023351867,-0.04563526,-0.048929185,-0.016825171,0.036066324,0.020605998,0.033005893,-0.022950854,-0.09849113,-0.06553608,0.064365424,0.03353199,0.0019656504,-0.03084807,0.0061076335,0.0032992724,0.034643188,0.0695251,-0.010879051,0.009466093,0.01941195,-0.0021454047,-0.045589257,0.08098689,-0.02463413,-0.0144614875,0.002152319,-0.006243242,-0.06543197,-0.021300143,0.09829666,-0.030010866,0.038936086,-0.020709667,-0.033623647,0.023293758,0.023001304,-0.047073394,0.037436776,0.030681986,0.036744192,0.049758773,-0.026097158,-0.016472816,-0.05037186,-0.0417193,-0.026877748,0.011204932,-0.041699544,-0.013749365,-0.0012303055,-0.04029338,0.09812981,0.039748196,-0.052318484,-0.022092234,-0.028504334,0.007650762,0.114825696,0.04674383,-0.027993629,-0.018135753,-0.010369114,-0.06644887,0.12462918,-0.013787892,0.019490737,0.036113713,-0.022392035,0.06740169,0.019471208,0.01640301,0.04060705,-0.0542529,-0.0042503476,-0.025240945,0.07498606,0.013906108,0.029121356,-0.0016295665,0.03982559,0.03695787,-0.011052226,-0.11381463,-7.2909647e-34,0.048791233,0.018517232,0.0328789,0.05868072,0.03048982,-0.039689373,-0.06666441,0.062685154,-0.0784351,-0.017256306,0.03012297,-0.02172306,0.09150718,0.06858972,-0.012495566,-0.04938538,-0.0030273232,0.009942182,0.036289807,0.023599194,-0.02419636,0.043611396,0.013683896,-0.011219989,0.02638663,-0.045524538,-0.023694424,0.012747608,0.03497196,0.028655153,-0.06140139,-0.04558958,-0.061581936,0.00044491797,0.022092907,-0.0736256,-0.017970996,-0.11586121,-0.037250068,0.12715776,0.07523851,-0.009872361,-0.032526888,-0.059866358,0.03732165,-0.05301622,0.0094666025,0.068294875,-0.046049573,0.03473809,0.066418454,-0.0017328365,0.10014288,-0.037371796,-0.043094974,-0.0023337216,-0.11713429,-0.023031602,-0.012752144,0.019157868,0.045801595,0.05265898,-0.04827542,0.08165882,-0.034945365,0.0012591529,-0.113846004,-0.045255724,0.022863097,0.011644958,0.04162594,-0.06995092,0.06986603,0.06852588,0.052683726,-0.03103543,-0.08456457,0.07629274,0.01550625,0.008043799,-0.032962166,-0.030216523,-0.0047717937,0.012659319,-0.013661624,-0.019022474,0.012552768,-0.011195716,0.057955656,0.036992833,0.013501475,-0.05539903,0.010729683,0.010248265,0.008637609,3.0390476e-34,0.11707161,-0.11176221,0.028150737,-0.14693241,-0.040518284,0.01654803,0.024072658,0.048231054,0.012594176,-0.03419324,0.08144278,0.018535934,-0.039651062,-0.14409792,0.044639975,0.07035388,0.028229529,-0.036949392,0.025386631,-0.011483927,0.07137056,0.0033425884,0.07966911,0.041421153,0.04504845,0.04033378,-0.021963222,0.012676326,-0.0067644175,0.07472942,-0.059524648,-0.03494413,0.01656407,0.026816295,-0.08251014,0.029409802,-0.06594237,0.0022709942,0.040664464,-0.016243028,-0.015120245,0.052266482,0.024844121,-0.0072771125,0.084910624,-0.0057397676,0.0048287157,0.024146093,-0.020092288,-0.08399242,0.010219694,-0.0044994988,0.010623821,0.02681171,-0.005494909,0.018454539,0.0004436676,0.014524339,0.054063838,-0.04376027,-0.05717457,-0.018479355,0.022806242,-0.019111348,0.103186905,0.08522497,-0.0051963357,0.019691102,0.023707988,0.03407463,0.068440706,0.023070484,0.012464707,0.048459753,-0.007457452,-0.05651361,-0.072786085,-0.0395488,-0.07841328,-0.06700283,-0.06866041,-0.09049328,-0.034059398,-0.045381512,-0.03792067,-0.060211796,0.027074091,0.101217665,0.049979027,0.04378627,-0.03496301,-0.010864984,-0.050534103,0.08245586,0.099474914,-4.496371e-08,0.05937339,-0.042977486,-0.01567972,-0.04387729,0.06095986,0.040145937,0.032647762,0.031201778,0.06516538,0.01328102,-0.0097362045,0.063976206,0.09679104,0.006132726,0.02512586,-0.01828354,0.03845071,0.003608468,-0.0014096453,-0.04245616,-0.011130361,0.0040312037,-0.03653496,0.10262314,-0.045642138,-0.024496315,0.023433533,0.0404743,0.011947564,-0.05509628,0.01738723,0.06346877,0.01332815,0.028770538,-0.044956226,-0.031334516,0.038956802,-0.07128811,-0.078958824,0.070603386,-0.030807277,-0.013864198,-0.056001298,-0.0064920182,0.09765524,-0.0542858,0.0062132804,0.049580723,-0.009100379,-0.03207719,0.009464333,0.008129769,-0.053884853,-0.012093362,-0.061961245,-0.030880922,-0.023093013,-0.051133715,-0.030863518,0.00057565793,0.026002081,0.0021264066,0.16140544,-0.060620777 +1.3.1.94,"The enzyme, isolated from human fetal brain tissue but present in all eukaryotes, catalyses the reduction of the terminal double bond next to the aldehyde group in ditrans,polycis-polyprenal, as part of the pathway that produces dolichol. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.",384,1.0,-0.004373474,0.015360367,-0.062395904,0.0032495137,-0.052625567,0.02933143,-0.09389733,0.08029937,0.1294367,-0.015297414,0.032741494,-0.022925155,-0.09103857,0.027434554,-0.041928373,0.058980297,-0.06962442,0.028493868,-0.014107967,-0.04275632,0.010542598,-0.036113612,0.0411973,-0.035530288,0.06406049,0.012167913,0.011157742,-0.041973192,0.034829106,-0.0074667423,0.036182277,-0.06310498,0.011344076,-0.04699118,0.004165741,0.037742402,-0.048946418,0.005471119,-0.00029550146,0.014941178,0.05191623,-0.043404806,-0.05145343,0.0015505592,-0.06290769,0.0013845086,-0.046203487,0.033328865,-0.03242677,0.060655344,-0.053908687,-0.03519815,0.019132264,0.05867977,0.072393715,0.018585518,-0.044529963,0.072221905,-0.020693932,0.063992165,-0.001309777,0.042647775,-0.11196331,0.021511542,-0.025397997,0.033178646,0.014986678,-0.077452414,-0.056061577,-0.017548412,-0.03507513,-0.031615652,0.1228688,0.008924988,-0.005597778,-0.046618156,-0.004904145,0.04182512,0.0702627,-0.031209975,0.034651373,-0.014129952,-0.0029859163,0.100430965,0.004836207,0.05540514,-0.008603208,0.06803661,-0.018535683,0.008810377,-0.0444415,-0.036452647,-0.059551947,-0.020138443,-0.056768816,0.053887554,0.049250644,0.10316502,0.033861,0.026289595,0.03211636,-0.014764248,0.011369199,-0.036689915,-0.09987239,0.0041668406,-0.016530234,0.013136244,0.032109283,0.010876355,0.05622183,0.059044942,0.04811487,0.06043384,0.008869936,-0.032886222,0.046567295,-0.0461695,0.008184147,-0.06045913,0.022908783,0.00332053,0.050286584,0.10915705,0.018817283,-0.061365604,-0.042272862,2.1754626e-33,0.08952902,-0.00915573,0.00046475712,0.024700047,0.0049288645,0.014332911,-0.0028214457,0.00845359,-0.13701744,0.02801572,-0.055005006,-0.12722693,-0.0017998561,0.07157417,0.049339276,-0.025140058,0.040201824,0.0043793195,0.12799074,-0.043868806,-0.013138503,0.019532159,-0.022910932,0.02345132,0.016250214,0.034984145,-0.06121286,-0.029791785,-0.014032683,-0.002366432,0.007323541,-0.06800448,-0.092575334,0.05029174,-0.074247085,0.04978527,-0.08785636,-0.019266589,-0.050410166,0.0383594,0.07047843,0.024785299,-0.020007132,-0.08519265,0.095462,-0.003958392,-0.0045888363,-0.008808745,0.038924206,0.034080274,0.073427476,-0.006455787,0.045623228,0.0006220688,-0.16283749,0.09057687,-0.05397196,0.000689904,0.0033267045,0.09607107,-0.05342569,0.052986495,-0.060478862,0.013467556,0.012353946,-0.021706745,-0.041852918,-0.06444329,-0.030228944,0.05084114,-0.03983284,-0.042518854,0.036608826,-0.048377458,-0.049007792,0.008331134,0.0034773701,0.07106155,0.024732398,-0.030933015,0.068989776,0.020252258,0.054390863,-0.048535563,-0.0036366642,-0.002285753,-0.008647762,-0.028791294,-0.07270342,0.00074596395,0.003369178,-0.13419083,-0.09243541,0.005865064,0.041466497,-4.3743087e-33,0.007851984,-0.09987485,0.04001801,-0.06505225,-0.05620498,0.07848955,0.006052439,0.03906955,-0.020577528,-0.029570872,0.093778595,0.0053376113,0.05460649,-0.040661145,0.01556601,-0.036160115,-0.017686874,0.080432124,0.038123105,-0.0662783,-0.0039105397,0.06165249,-0.00959928,0.024531573,0.032443494,0.017387006,0.06489726,0.036542375,-0.009066227,0.0416758,-0.033237,0.02817378,-0.041193057,-0.05053992,0.06141797,-0.025725888,-0.14951706,0.045776308,0.014574492,-0.0028646677,-0.09665685,-0.007349416,0.036304716,0.033427306,0.0010246552,0.08732167,-0.06578154,-0.035998363,0.0022169068,-0.041874185,-0.004003029,0.009038203,-0.0660044,-0.04275375,-0.0009868966,0.044623032,-0.004857954,-0.067808285,0.07922724,-0.09916171,-0.07129604,0.006235312,0.011237419,0.041532043,0.026991993,0.064628415,-0.029828394,0.03992648,-0.025009487,-0.05112575,0.0708501,0.07034331,-0.040133763,0.032687727,-0.03103748,-0.05289908,-0.04806357,-0.023497343,0.026681479,0.07109863,0.022031821,-0.024823127,-0.003992253,-0.054222383,0.03048935,-0.107371435,0.08270344,0.13974833,-0.026129482,0.008099201,0.012747912,0.0648855,-0.09158431,-0.0022822074,0.11926437,-4.0151022e-08,0.0017782415,-0.055145543,-0.07672449,-0.028983913,-0.06197479,-0.022283096,0.044220354,0.070808046,-0.040864807,0.0024827733,-0.021912828,0.024779227,-0.06336821,0.0674541,0.020342868,-0.00040650452,-0.054764867,-0.049363244,-0.03738585,-0.031533282,0.00044786936,0.020521238,0.013874893,0.0323529,0.033910945,-0.093317874,-0.03546487,0.047790613,-0.016096862,-0.014934683,0.020988198,0.05100083,-0.007840433,0.019640053,-0.015493071,-0.014674749,0.025994442,-0.016624874,-0.017881224,0.066095866,0.017832508,-0.1171871,0.037848722,0.01095038,-0.04829642,-0.0049837674,-0.031242914,0.041383136,0.017424019,-0.00072331156,0.019793315,0.029223293,-0.039230894,-0.056106456,-0.07710135,-0.025705783,-0.051729184,-0.021571558,-0.04311128,-0.03624602,0.0632978,-0.0040733158,0.21151415,-0.04807205 +1.4.3.24,"Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacterium Pseudomonas sp. HZN6, is involved the nicotine degradation.",384,1.0,-0.059634726,-0.016644271,-0.06967039,-0.051142685,0.067956455,0.013663461,-0.071058884,0.094522424,0.029743472,0.013329887,0.0030597618,-0.02081418,-0.11925629,0.038687482,-0.024261631,-0.016838117,-0.08075249,0.020585762,-0.059069183,0.040428635,0.059095174,0.13042317,-0.014538149,0.007551129,0.00040407304,0.03694605,0.014318345,0.005764235,0.05919903,0.038016472,-0.0064933626,0.054717947,0.005136063,0.0050083376,0.050037757,0.023474311,0.04066033,-0.014227112,0.08418596,-0.012307174,0.0436848,0.033085696,0.04846678,-0.011691984,0.032378677,0.0101257255,0.0050762254,0.0035762696,0.006347819,-0.054222662,0.03645661,-0.04289005,-0.032167368,0.07012243,-0.037939172,0.026255896,-0.041128457,-0.04260742,-0.008210425,0.021728853,0.027317677,-0.014493698,0.0066223904,-0.0061157765,0.09623917,-0.047802053,0.016057061,-0.08946302,0.03552253,-0.00919015,-0.09031358,-0.035357833,0.025623819,-0.0007905675,0.044445284,0.026961302,-0.119152755,-0.03817756,0.07743895,-0.06716156,0.046214443,-0.02690079,0.083706,0.126272,0.015138871,-0.076224774,0.08517613,0.0200461,0.021091925,-0.039615113,-0.014611583,0.0234501,-0.008956836,-0.03676344,-0.20102826,0.064168826,0.05424697,0.024487335,-0.0339714,-0.013357697,0.030344281,0.07214671,-0.015511947,-0.04813548,-0.027604563,-0.012371798,-0.009614635,0.08192971,0.03328919,0.026803521,-0.007478516,0.03614585,0.0016065614,-0.048130542,-0.01219914,-0.015837261,-0.006060352,-0.050547816,0.011476304,-0.030227324,-0.04700467,-0.023753384,0.03796762,0.08045667,0.09074503,-0.04790996,-0.084063604,6.3666124e-34,0.02704079,0.0068337037,0.002623475,-0.03005365,0.031395555,-0.028708374,-0.061797164,0.0005879695,0.01991593,0.017231055,-0.01848238,-0.047897436,0.0078650145,0.025026359,0.011501384,0.05420876,-0.068290636,-0.09493585,0.09413976,-0.068198204,0.052481864,0.074108385,-0.018339273,0.08575562,0.008229037,-0.031798746,-0.061612617,0.051303525,-0.02712053,-0.013104153,0.07091967,-0.029065734,-0.104094505,-0.06133615,0.04479617,0.06466769,-0.0311617,0.015230179,-0.06579386,0.0475445,0.07118493,0.0002786928,0.06781975,-0.026482118,0.049467728,-0.07536119,-0.07809263,0.045470756,0.030889198,0.07696984,-0.045481894,-0.062253904,0.07213136,0.031842094,-0.07887165,0.0059031085,-0.015616426,0.0019661218,-0.015685389,0.029939625,-0.0020466843,0.00812987,-0.057116963,0.11881009,-0.033741143,-0.0135272425,0.01935971,-0.08837447,0.04589376,0.11421852,-0.04408553,-0.020282188,0.06282244,-0.005372081,0.0051166,-0.10570327,-0.018371265,0.00087652146,-0.015324874,0.06108005,-0.030431764,-0.092046455,-0.044264324,-0.073655814,-0.08512746,-0.042875763,0.03260361,-0.09368529,0.020759381,0.0027130947,0.035758205,-0.09893522,-0.014932527,0.027155058,-0.020233681,-7.044539e-34,0.033997115,-0.028873939,0.11595388,0.017526383,-0.01280344,0.06180088,0.020426227,0.027220597,0.0120537765,-0.10750736,0.09123527,0.030519309,0.06140467,0.021814788,0.033563837,0.10359835,-0.040212978,-0.009503135,0.0625931,0.05180146,-0.040313855,0.030501492,-0.038619455,0.08236828,0.03166866,0.020925783,0.0012988029,0.03668051,0.03254281,0.026101159,0.0070427754,0.05938413,-0.07420565,-0.046888366,-0.09926421,-0.04215762,0.024380753,-0.015947472,-0.07265753,-0.02787147,0.057879735,-0.0040117884,-0.052969445,0.068394385,0.033156242,0.01857126,-0.05891585,0.000525882,0.04332272,-0.03253191,0.053398494,0.016778436,-0.050033342,0.0133687025,0.088205814,0.03143029,-0.048308466,0.042592287,-0.0069856304,-0.0055405977,0.0156012615,-0.08314521,-0.04273599,-0.056682467,0.07157777,0.040255178,0.00041305,0.10843665,0.035400756,0.0049279556,0.070646524,0.06376391,0.045431826,0.0053691855,-0.07421389,-0.046656877,-0.0018242002,-0.037325107,0.007787911,0.026577156,0.051048845,0.030480914,-0.04306992,-0.0013267521,-0.040259507,-0.010497742,0.045845192,0.088878214,-0.051196434,-0.0011485387,0.013674028,0.0044382075,0.025976202,-0.0035320225,0.042418648,-2.8505633e-08,0.06909972,-0.074458554,0.016083887,-0.06420591,0.04462789,0.053015932,0.043391176,0.02908548,-0.021539416,0.037710737,-0.021377135,0.10259498,-0.051401857,0.0271757,0.027424658,-0.0015749393,-0.11627664,0.04126518,-0.08384908,-0.016396018,-0.10194281,0.050002173,-0.049642503,-0.011016244,0.0052148164,-0.0045392322,0.02911902,-0.024657577,-0.013321382,0.016571213,-0.0029993814,-0.009216929,0.047347497,-0.026541872,-0.11468662,0.003654703,0.040967822,-0.07306451,-0.06852844,0.0067929267,0.0059419707,-0.019317301,-0.11466259,-0.029916057,0.02140531,-0.03171884,-0.028141508,0.045110837,-0.04545114,-0.023996769,0.039146286,0.0029507629,0.010087914,-0.04815328,-0.13109468,-0.045333065,-0.044030637,-0.025903748,-0.017804375,-0.0168448,0.05031406,-0.027211629,0.117905684,-0.031622738 +1.5.3.19,A flavoprotein (FAD). In the enzyme from the soil bacterium Arthrobacter nicotinovorans the cofactor is covalently bound. Participates in the nicotine degradation pathway of this organism.,384,1.0,-0.07880272,-0.02989447,-0.10037965,-0.029504472,0.08114951,0.035366513,-0.029767126,0.03788386,0.04423549,-0.016969636,0.014413994,0.00020644108,-0.1301831,-0.012515518,-0.055877734,0.0036845559,-0.06266838,0.007757676,-0.059820496,-0.0061884597,-0.00880941,0.0650518,0.016231807,-0.055872463,-0.02457967,0.008708295,-0.042232126,-0.06629311,0.014709865,0.025721211,0.057300985,0.058897674,0.021706726,0.030187361,-0.04223287,0.03355221,0.039233822,-0.055112258,0.013001146,0.044060525,0.03133807,0.04723144,0.033812955,0.0069798743,0.042165317,0.052703727,-0.008329996,0.036247287,-0.014076681,-0.0047015185,0.01613934,-0.018785696,-0.10647813,0.023065405,-0.03194261,0.025036687,0.03903216,-0.07187148,-0.009909839,0.00641204,0.053516917,-0.023522638,0.06543005,0.013666932,0.08738473,-0.09862415,-0.021729065,-0.0382877,0.019694224,-0.035419244,-0.030101947,-0.033345133,-0.057316083,0.035208378,0.04235299,0.072933726,-0.14739497,-0.029859936,0.09911547,-0.054315735,0.08698618,-0.011201541,0.06430256,0.10652578,0.020848995,-0.07068371,0.04056534,-0.026733365,0.03514672,0.028685274,-8.9512825e-05,0.015309093,0.017484594,0.04408879,-0.16221182,0.043257587,0.099151656,-0.034014642,-0.105474316,-0.008420863,-0.04996944,0.011793874,0.0104162665,-0.010726552,-0.06924012,-0.078380466,-0.03525503,0.046532143,0.020686273,0.00877161,-0.014135411,-0.0031875097,0.011923902,-0.09396189,0.020310048,0.0029045395,-0.020101124,-0.046197873,0.045442697,-0.043038465,-0.04468797,0.04709037,0.03275932,0.067029536,0.08487016,-0.025988992,-0.12126947,1.246973e-33,0.07148879,-0.009770873,-0.0054809423,0.011975338,0.020859472,-0.022214288,-0.07423255,-0.011335515,0.019482741,-0.03888883,-0.011433204,-0.015342766,0.0023060406,0.0014360107,0.0373715,0.06004395,-0.079551145,-0.077839285,0.08794258,-0.08415603,0.04365021,0.057124797,-0.01917656,0.09078355,0.011377805,-0.030981634,-0.096444316,0.018022848,-0.02790117,0.028288223,0.026171489,-0.022457717,-0.07837483,-0.035781432,-0.005464269,0.07024521,-0.04122085,-0.06522669,-0.14888094,0.023763744,0.04212886,-0.038848463,0.035074554,-0.015428795,0.029412989,-0.06618274,-0.086132,0.06451025,0.010715643,0.09805704,-0.025081385,-0.051478673,0.12827569,0.08569368,-0.09480837,0.04468644,-0.013978069,-0.01890787,-0.039772626,-0.002165313,-0.0015383674,0.048713036,-0.0052752267,0.12628418,-0.06728948,0.000816432,0.013936848,-0.080997474,0.09203798,0.13214354,0.006891275,-0.036708217,0.067854315,0.0032562558,0.010485684,-0.06284487,-0.042122427,-0.015917854,-0.04884327,0.04817218,-0.039073396,-0.064371556,-0.028819803,-0.06531152,-0.059293933,-0.010550717,-0.0010017661,-0.06334037,0.032068793,0.017159162,0.015249025,-0.02574601,0.04644331,0.028843798,0.013114287,-1.1982179e-33,0.022624867,-0.0884785,0.05525073,0.03728252,0.014108309,0.024466153,0.031776793,-0.018207444,0.010204253,-0.030595949,0.00801986,-0.018533807,0.040081806,0.03510909,0.06993309,0.046144888,-0.02891469,0.013081146,0.05657552,0.051038116,-0.08414086,-0.017661488,0.049027253,0.053222887,0.031107876,0.0049101003,0.02319087,-0.033529427,-0.019823488,-0.03393898,-0.0026770153,0.05012437,-0.056723114,-0.043793876,-0.10325982,-0.008359531,0.0065027843,-0.019697793,-0.041177772,-0.012768822,0.027068188,0.010508175,-0.036253925,0.045773946,0.053892463,0.0050047403,-0.035223637,0.04683837,0.07406601,-0.0002898578,0.043094292,0.045309063,-0.029680217,0.048402697,0.07593676,0.07450604,0.017384363,0.086512506,-0.0034372804,0.061019383,0.026626062,-0.055520114,-0.025601171,0.004183069,0.10644226,0.06392366,0.053400822,0.12608209,0.028561996,0.012937787,0.099979825,0.061085608,0.07370086,0.044060066,0.014124278,-0.060762413,-0.0017638893,0.058422465,0.00064259785,0.027377622,0.00033660728,-0.015508573,0.017592428,0.04468099,-0.07440182,-0.1272151,-0.028084477,0.0682244,0.007279698,0.032616954,-0.025127595,0.0053753234,0.005944955,-0.0487396,0.024027504,-2.8705433e-08,0.013680507,-0.026760126,0.007327423,-0.028443703,0.08603528,0.029434567,-0.013181914,-0.043415092,0.0018460029,0.01665709,-0.01505898,0.10861606,-0.025278045,0.02826164,0.06058261,-0.020042568,-0.034288123,0.013061323,-0.0606289,0.021766169,-0.09702976,0.045657214,-0.06121214,0.018200543,-0.045483354,-0.036274854,-0.0045319884,-0.028197026,0.03147789,0.031786893,-0.01508438,0.029156499,0.030090036,-0.04525433,-0.13437217,0.026916156,0.048106708,-0.10215967,-0.011069917,0.06163998,-0.058321662,0.020334946,-0.04097916,-0.04999311,0.006342348,-0.0063479217,-0.001410092,0.0072505237,-0.06401042,-0.009363945,-0.03045093,0.010768521,0.008350315,-0.007396707,-0.09136827,-0.06888255,-0.0054068496,-0.050914697,0.006187398,-0.04399447,0.012856638,0.005444577,0.12854923,0.00938953 +1.5.3.20,"Isolated from the mold Cladosporium sp. G-10. Acts on N6-(carboxymethyl)lysine, 6-[(carboxymethy)amino]hexanoic acid, sarcosine and N-ethylglycine. It has negligible action on glycine (cf. EC 1.4.3.19 glycine oxidase).",384,0.99999994,-0.02441495,-0.04184881,-0.10168273,-0.049935892,0.09514216,0.10002736,-0.032222416,0.031049661,0.015063164,-0.06243576,0.077342175,0.040778793,-0.051942125,0.01637339,-0.065725386,-0.042857036,0.041552242,-0.009913684,-0.029687453,-0.012151863,0.046986062,0.08667187,-0.038808767,-0.028782662,0.015617418,-0.05823839,0.05501005,-0.05025677,-0.02701399,-0.10139439,-0.006051873,-0.043306574,-0.012367994,-0.064759634,0.007488184,0.050717805,-0.020550607,-0.034058575,0.04500688,-0.010001736,0.001196862,-0.016968891,0.050580993,-0.07560583,-0.019249354,0.0059910207,-0.049875036,0.034928787,-0.005798786,-0.010982735,0.017736642,-0.05376036,0.026727008,-0.02394543,-0.02277385,-0.014335852,-0.13912319,0.01299567,-0.023288589,-0.004768577,0.047454707,0.030003006,0.054112583,0.008320403,-0.046907306,0.03932891,0.043250218,-0.023409368,0.010374392,-0.07437371,0.043682337,-0.046809405,0.067326695,-0.040197372,0.0033668168,0.05092244,-0.049150236,-0.010195451,0.09088382,-0.01696075,0.0072744675,0.0701673,0.04534795,0.07103843,-0.06457733,0.026166137,0.01045631,0.13305236,-0.016528053,0.0029035718,0.03149027,0.0072090733,0.041567106,0.016830321,-0.060990416,-0.01854402,0.012951169,0.061319936,-0.056297924,-0.023077086,-0.02136501,0.03672216,-0.06380866,-0.06330561,-0.05854294,0.069231145,-0.024703322,-0.0037180176,0.06693202,-0.0023953866,-0.08371908,0.0782881,-0.033922877,-0.06856827,-0.006373153,-0.015966333,0.07089242,-0.014677437,-0.05317468,-0.016847437,0.046409152,-0.020281972,0.05147476,0.01498195,-0.0020164647,0.060554855,-0.02056618,2.8097246e-33,0.08107205,0.009152823,0.06262303,-0.0049263206,0.12639031,-0.05512251,-0.008013666,0.026217977,-0.047545105,0.016892143,-0.13669695,-0.043561243,-0.039026804,0.045197453,0.0005568112,0.036203124,0.014727686,-0.036324617,0.0280443,-0.035440065,0.040764343,0.09657666,-0.018101064,0.09678763,0.01572844,0.03605242,-0.014677474,-0.06878147,0.04402592,0.015647875,0.015536605,-0.12635145,-0.07833195,0.021948917,0.044184398,0.0099001285,-0.0921098,-0.027549993,0.049645774,0.0027513239,0.07774434,0.05129869,0.006308991,-0.023672218,0.05201305,0.016124062,-0.04232689,0.078526095,0.007515895,-0.01782453,0.056109477,-0.0154416,-0.005505982,0.015559486,-0.016634624,-0.010001567,-0.061171856,0.06183416,0.09656403,0.0623031,0.027788658,0.096331626,-0.024673855,-0.021016022,-0.018219821,0.018241655,-0.13556288,-0.023650592,-0.06683066,-0.018938683,0.012864423,-0.067396045,0.02768778,0.030850345,-0.0064849774,-0.027849289,0.032470774,-0.10943692,-0.010513441,0.008758798,0.029810522,0.05033495,-0.043490827,-0.0271439,-0.056817874,0.031738333,-0.007682297,0.012438147,-0.004515638,0.07884625,0.07084954,-0.020226905,-0.023259908,-0.06431738,-0.046620633,-2.854487e-33,0.09241277,-0.08708039,0.035192695,-0.04760216,-0.011417119,0.0032240169,0.0019814211,0.017733723,0.057951964,-0.049170993,0.018952884,0.043877993,0.035209913,-0.033678103,-0.039233975,0.061103493,0.030938774,0.09600821,-0.006834965,-0.044930987,-0.070698686,0.013484153,-0.019955732,-0.04096215,0.019571198,0.043004733,-0.019331317,0.11066011,0.014457148,0.040270872,0.00576381,0.0037931518,-0.021460112,-0.043535527,-0.04072359,0.04228055,-0.048472486,-0.07728597,-0.000107466454,-0.038284555,-0.068003856,-0.01335705,-0.0147596095,0.092954345,0.11313636,0.07774352,-0.08014798,-0.05658406,-0.03262097,0.0219356,0.06340071,-0.019358944,0.009332328,0.0026683598,0.027044754,0.03804315,0.008399022,0.009126576,-0.029871844,0.0567587,0.071486264,-0.015985535,-0.05101537,0.026713232,0.077978164,0.08010852,-0.015859298,0.034515396,0.060660027,-0.054014333,0.08891223,0.034567192,0.038197394,0.036874127,0.021372307,-0.006108765,-0.09589187,0.004574428,0.0016965399,-0.005180053,0.0036472012,-0.019597108,-0.012558963,-0.0050514936,0.06952001,-0.052792076,0.10156456,0.11686705,0.046452247,0.05536093,-0.058780715,0.041951682,-0.017052723,0.04047535,0.06658437,-4.1401105e-08,0.07331135,-0.074705966,0.054552943,-0.09986105,-0.0658995,0.011039635,0.08239728,-0.014425523,-0.010054705,-0.045596108,-0.02126883,0.039678406,-0.03470172,-0.026958697,0.015948927,-0.016673129,-0.023396276,0.054254927,-0.057257403,-0.002065475,-0.024714429,0.09523566,-0.07475404,-0.010627758,-0.04906469,-0.027633315,0.092299804,-0.015746359,-0.017118948,-0.0061632325,-0.00039625893,0.028037587,-0.028120818,-0.051527996,-0.078429595,0.025315605,-0.027728433,0.06495391,-0.018630847,-0.037108768,-0.03494629,-0.06857872,-0.051897857,0.00083662226,-0.013079138,-0.029951882,-0.027576372,-0.012008144,-0.06893697,0.005034035,0.03358909,0.031826876,-0.028193928,-0.01597965,-0.16365395,-0.046966176,0.026044553,-0.052371014,-0.009439841,-0.13791545,-0.14007393,-0.031643916,0.13728407,0.029661512 +1.5.3.21,The enzyme participates in the nicotine degradation pathway of the soil bacterium Arthrobacter nicotinovorans. Has a very weak monoamine oxidase (EC 1.4.3.4) activity with 4-aminobutanoate [1].,384,0.99999994,-0.0076641957,0.0065253437,-0.0012743587,-0.0381352,0.041977648,0.0658165,-0.047253683,0.014743145,0.068251766,0.05229816,-0.042282313,-0.043822076,-0.060194746,0.010806343,-0.0063058203,0.058812127,-0.07636377,0.04057197,-0.03137584,-0.030919915,0.042981245,0.081013255,-0.012806176,-0.044394825,-0.045589227,0.01724451,-0.08722914,-0.038397796,-0.023493694,-0.0029067285,0.022611817,-0.06344138,0.030644089,0.034099232,-0.0033602747,0.03315988,-0.023290945,-0.09556194,0.04542787,0.04094827,0.003039508,0.099573344,-0.04364535,-0.023469348,-0.053769533,7.011434e-05,0.059572868,-0.06775574,0.047328707,-0.030892732,0.037656497,-0.030472593,-0.006822898,0.01834268,0.022444475,-0.010018944,0.0016816844,0.013091249,-0.020800672,0.052884903,0.079258464,0.04879974,0.024650931,-0.021229308,0.02856868,-0.058740973,0.028251205,-0.029108416,-0.015555048,-0.06321848,-0.11003246,-0.066386245,-0.031708475,0.02155075,0.0055622305,0.025860379,-0.13221885,-0.0075299717,0.050124105,-0.08188173,0.0119215725,-0.062326755,-0.03356245,0.12030041,-0.005356503,-0.02470374,0.04834179,-0.02559208,0.15031722,-0.01648044,0.024544746,0.0019633844,-0.0037644268,0.0070610824,-0.10030135,-0.052546408,0.10151034,0.023653422,-0.08712859,0.023414934,-0.011647041,0.04521348,-0.025477404,-0.09909139,-0.039649792,0.033678018,0.01394272,0.017090624,0.03631771,0.05656019,-0.025513338,0.014144881,-0.019524992,0.018257275,-0.012761274,0.07875461,0.0035300457,-0.025483098,-0.09063054,0.001658839,-0.04640489,0.0016123693,0.08557254,0.022032058,0.030611003,-0.04920702,-0.060636785,9.005103e-34,0.022240626,0.028188772,0.02192139,-0.01610605,0.0929576,0.0011101348,-0.017766632,0.060175788,0.0807982,-0.047665566,-0.040376406,-0.09901774,0.0094719315,0.054913756,-0.014193628,0.042814713,-0.07779582,-0.07524584,0.03431057,0.036767665,0.01897346,-0.025338031,-0.04231474,0.085127376,-0.025936762,-0.005738181,-0.031882096,-0.00018985521,-0.022298463,-0.017177561,0.037357833,-0.022405338,-0.16799615,-0.1253156,0.066893026,0.026382644,0.030594949,0.03462661,-0.08904223,0.03468109,0.047054764,0.0008515282,0.047737133,-0.056666758,0.037172597,-0.052981026,-0.06456344,0.09280438,0.10468175,0.07031837,-0.049493656,-0.1067771,0.10908363,-0.020002155,-0.060714707,0.053123012,0.018519381,-0.018888017,-0.025304388,0.031621248,0.0236305,0.0067566102,-0.014612693,0.029479936,0.00152793,0.014283586,-0.01799101,-0.08995583,0.07943648,0.08694478,-0.032094132,-0.039789237,0.023122203,-0.0010962351,-0.02609314,-0.07837876,-0.14380352,0.06457744,0.023667235,0.034266464,-0.029807007,-0.086498916,-0.013143134,-0.036539495,-0.016212093,-0.0091063455,0.09738856,-0.054303937,0.019605286,0.07718324,0.059592444,-0.05251178,-0.00097332057,-0.021886861,-0.0323034,-1.25705355e-33,0.013928997,0.0025800732,0.0016515374,-0.009306738,8.67926e-05,0.024100486,-0.0029524143,0.062913015,-0.055414885,-0.007877526,0.064272895,0.048497833,0.092839964,0.0061731054,0.03150058,0.010044241,0.012333468,0.036139365,0.023770068,0.018106963,-0.07983758,0.02987904,-0.0144248,-0.03147091,0.011021488,-0.0018021247,0.009552456,0.07962338,0.035693098,-0.0681789,0.025970787,0.09183163,-0.009086807,-0.03832742,-0.03836504,0.04893345,-0.033658013,-0.08106271,-0.009258034,0.015999934,0.04128844,-0.015419552,-0.032061487,0.054367885,0.026862852,0.005662356,-0.13148434,0.027003955,0.0011828574,5.434897e-06,0.08478903,-0.0021859694,-0.063120954,0.010904766,0.08969533,0.039282665,-0.062498122,0.033369504,-0.0073246136,0.002397821,-0.038703185,0.041422155,-0.020088047,0.04021482,0.023745177,0.04987632,0.022306606,0.0789633,0.047110807,-0.019835763,0.04341125,-0.00018437994,0.14150122,0.0034151922,-0.04773191,-0.08576592,-0.041631468,0.019762907,0.026298549,-0.060498804,-0.031659503,-0.0022069353,0.031317353,-0.08839474,-0.010404182,-0.03768762,-0.06629974,0.0727622,-0.011340282,0.04531986,0.01459365,-0.07895189,-0.02686122,0.04508715,0.023229256,-3.294578e-08,0.03021905,-0.030723589,0.030242909,0.013739176,0.049672388,-0.0011510738,0.06784021,0.041724477,0.04168853,0.010301309,0.062388163,0.07077482,-0.02997845,0.07615801,0.019524593,0.05152912,-0.032437965,0.07728003,-0.039814487,0.08176724,-0.10371237,0.006910018,-0.056367766,-0.022937406,0.07841044,-0.042085648,-0.029738279,-0.015187566,0.009051209,0.02867118,0.042430792,0.046250544,0.008770131,-0.07304049,-0.11573993,-0.010258386,-0.017407278,-0.03348407,0.0028081015,0.0040883315,-0.008886823,0.009393792,-0.119032025,-0.015701558,0.09194625,-0.028458545,-0.063776135,0.05416429,-0.039403982,-0.054269638,0.013952692,0.02259656,0.039740082,-0.044767596,-0.13909778,-0.03817687,-0.01366222,-0.027660547,0.0048643574,-0.018960537,0.008765615,-0.03486736,0.12661546,0.007514169 +1.5.99.14,"Contains a cytidylyl molybdenum cofactor [3]. The enzyme, which participates in the nicotine degradation pathway, has been characterized from the soil bacterium Arthrobacter nicotinovorans [1,2].",384,1.0,-0.050200213,0.0026936643,-0.06807356,-0.050597165,0.029118765,0.026745638,-0.046638817,-0.04177454,0.036503427,-0.0285314,0.00017661041,-0.03776874,-0.039104357,-0.010416744,-0.046863846,0.01809424,-0.02203843,0.07338835,0.0009155896,-0.00190708,0.0340331,0.12214183,0.028160583,-0.025272937,-0.036258493,0.06366435,-0.10467936,-0.022217534,0.027261242,-0.029513156,0.0064270045,0.042030513,0.0019037875,-0.022029534,0.07891561,0.017096123,-0.03976105,-0.046177533,0.064365305,0.03992872,0.011649614,0.088749014,0.012852617,0.012456325,-0.038592957,0.02652681,0.040844034,-0.06777302,0.0067237862,-0.025882546,0.010694491,-0.02498523,-0.043003738,0.028000258,0.022002773,0.021738483,-0.036461305,0.022631226,0.010700083,0.023343025,0.07240993,0.057257984,0.07698787,0.0052902694,0.010827169,-0.04827332,-0.014426763,-0.074610084,-0.003719863,-0.08153705,-0.12200485,-0.06822051,-0.009283368,0.051119618,-0.02965853,0.09039684,-0.094428524,0.00063128944,0.096476056,-0.05038752,0.020412158,-0.027088488,0.0073522525,0.11654516,-0.0104687,-0.03760641,0.033147383,-0.022085996,0.08843873,-0.053382214,0.06032399,0.011952854,-0.0012864897,0.011976445,-0.12337747,-0.023901334,0.124682084,-0.0015127092,-0.070749275,-0.014251903,-0.010056038,0.03463088,0.01736826,-0.07851285,-0.09854379,-0.0008593968,-0.0016137247,0.028786208,0.07892808,0.042111106,-0.060535237,0.04587336,-0.028258923,-0.06693574,0.03293562,0.013302496,0.030860687,0.0027690607,-0.004591312,-0.06025297,-0.013302445,-0.057917893,0.024491217,0.003232296,-0.009280086,0.010505206,-0.075714655,1.773452e-33,0.04658571,0.017227326,0.066953495,0.03230402,0.041692637,-0.037041634,-0.019295847,-0.0003051367,0.011480758,-0.085307695,-0.014346347,-0.09331589,-0.043090962,0.060117457,-0.030227385,0.04310306,-0.09883839,-0.119877174,0.050208386,-0.002948885,0.035846166,0.058412824,-0.038366914,0.077245705,0.009659182,0.0058401786,-0.023769831,-0.024962131,-0.015980195,0.0069964337,0.06135905,-0.05329762,-0.15766002,-0.09055846,0.065008745,0.046345614,0.002880175,0.006435963,-0.091508985,0.010199862,-0.002185896,-0.018123738,0.054640915,-0.056648098,0.033402506,-0.028723326,-0.05877323,0.08352982,0.08919111,0.01905105,-0.042822123,-0.09138357,0.06633758,-0.0063067,-0.109978296,0.09084447,0.04940084,0.010534579,-0.054847907,0.06258649,-0.028562056,0.041549917,0.005284058,0.06704307,0.016461268,0.0023271325,-0.070858665,-0.08862013,0.041567847,0.08537865,-0.05078124,0.009520111,0.03375975,-0.0089854365,-0.016480347,-0.08883696,-0.04091804,0.006852428,-0.025852373,0.03791636,-0.025234887,-0.08952724,0.016805587,-0.08116644,-0.020325055,-0.025115002,0.016530983,-0.07138985,0.0028709227,0.0856919,0.026233308,-0.03164369,0.01669668,0.07203208,-0.08272786,-2.682295e-33,0.052408874,-0.040120456,0.14237396,-0.005292943,-0.038626082,0.038444296,-0.010448647,-0.0073775537,0.003300528,0.012153929,0.012857043,0.051773638,0.08995823,0.011531062,0.02557243,0.04926355,0.043821566,0.0508725,0.011813466,0.007566569,-0.05316794,0.03635357,-0.0102985045,-0.07415649,-0.015492873,0.04661348,-0.0033746974,0.05483931,0.025619645,-0.082745835,0.024552569,0.066364445,-0.029436234,-0.08590679,-0.075773805,0.0053088698,-0.02778957,-0.07471862,-0.05565873,-0.039755628,0.0016821964,-0.014363961,-0.038065527,0.06983907,0.07798596,-0.017509706,-0.08317364,0.027405286,0.051811237,0.066309035,0.045686085,0.0035741876,-0.084475696,0.060477853,0.072260894,0.09254836,-0.05185808,0.046005867,-0.00858392,0.024686083,-0.019837273,0.014346156,-0.04399875,0.008325145,0.07643489,0.07858318,0.03295136,0.07948043,0.06402034,-0.04227882,0.043703176,0.056818392,0.04749365,0.022090117,0.001497965,-0.02124352,-0.042230945,0.010235726,-0.01602587,-0.03507875,-0.010899959,0.009461543,0.01377393,-0.057969503,0.020224292,-0.047961015,-0.03673231,0.10539007,0.030743865,0.0102894185,-0.017629037,-0.06037931,-0.037722975,0.013919447,0.02042615,-3.481815e-08,-0.0019023882,-0.05910496,-0.0006272092,-0.06922817,0.056667425,0.07119673,0.065650046,0.016090132,0.044145245,0.004910566,0.051916458,0.07566852,-0.013195008,0.035805095,0.0011545743,0.08543993,-0.087348916,0.003748206,-0.018108018,0.064499736,-0.07395562,-0.023788169,-0.039480906,0.069601715,0.014881361,-0.06266713,0.013504646,0.03208739,-0.019427145,0.05897357,0.008925215,0.01686054,0.01605924,-0.063528866,-0.115686,-0.024900451,-0.014649071,-0.06788616,-0.018479558,0.033614155,-0.024157124,0.0048846896,-0.057961326,-0.0136418585,0.041153956,-0.034249455,-0.081939854,0.052654885,-0.025061904,-0.03845316,-0.031619728,0.0010453893,-0.0030101452,-0.034275196,-0.15529901,-0.050255828,0.022106227,-0.0040504914,0.015096286,-0.04398168,0.013480669,-0.03602578,0.14750645,0.020457663 +1.13.11.64,"The enzyme, characterized from the soil bacterium Bradyrhizobium sp. JS329, is involved in the pathway of 5-nitroanthranilate degradation. It is unusual in being able to catalyse the ring fission without the requirement for prior removal of the nitro group. The product undergoes spontaneous lactonization, with concurrent elimination of the nitro group.",384,1.0,-0.07365792,-0.05377226,-0.070517115,-0.028926082,0.14368999,-0.017641962,-0.05767738,0.02462345,0.038507827,-0.0597163,-0.029988183,-0.00406782,-0.057356194,0.0049705952,-0.08446311,0.0016692028,-0.13391744,0.03201275,-0.04525771,-0.030451296,0.003948049,0.06889041,-0.045805987,-0.029075759,0.060085803,0.036961354,0.022551622,-0.02170781,-0.026533801,-0.10347745,0.07719138,-0.015440506,0.0069687436,-0.0685692,0.08121863,0.1093974,-0.08019079,-0.02913294,0.044974864,-0.0018688584,0.041886423,-0.01200588,0.066040695,-0.018922351,-0.026111234,0.05244925,-0.010930579,0.017450226,0.032412954,-0.029817402,-0.03349225,-0.04694613,0.011544709,0.05808276,0.040972684,-0.04211163,-0.00829052,-0.06841827,-0.024214447,0.035348088,0.09407509,0.039991498,0.04476723,-0.0012545581,0.036716454,0.007449924,0.051250536,-0.101419255,0.011250166,0.0047880667,-0.04877879,-0.0006048558,0.009437081,0.012729009,-0.006032493,0.01693258,-0.036955316,-0.012729411,0.06388186,-0.020599581,-0.0336605,0.0037514202,0.04524092,0.051444817,0.00049178966,0.02671033,-0.0066804225,0.011452608,0.09725342,0.03351212,-0.03881721,0.07469271,0.019831218,-0.014272735,-0.12990008,0.024125218,-0.028997391,-0.00846852,-0.05893703,0.030383179,-0.033587422,0.05338105,-0.061260384,-0.098875254,-0.11409868,0.04022128,-0.04247409,0.10901527,0.026941238,0.030948568,-0.025886698,-0.0013328021,-0.004168598,-0.018783864,0.021114472,0.058674216,0.052057628,-0.024663912,-0.07327615,0.066828884,-0.00885669,-0.02390416,-0.028202957,0.036038343,-0.09341117,0.06410003,-0.024062999,2.620116e-33,0.031973436,-0.0059943404,-0.039003048,-0.015527901,-0.005872989,-0.05868894,-0.09412681,-0.039652202,-0.04481616,-0.02785633,0.0076166764,-0.09780133,-0.0020340085,-0.10411655,-0.014613899,0.013304089,-0.02087263,0.050107036,0.0061879703,0.06129579,0.038792554,0.08519834,-0.08777672,0.06681886,0.049774006,0.04101412,0.036464106,0.0042334255,0.06790126,-0.017893426,0.018258188,-0.04662645,-0.13612933,0.022047877,0.08915345,-0.04377455,0.027424868,0.010142324,-0.024327952,0.10360829,-0.013236485,0.05479458,-0.038732585,-0.008099127,0.070367895,-0.020072866,0.03208952,0.16518947,0.08433095,0.0032624416,0.02566969,-0.016525267,0.09270637,-0.023395706,-0.015699696,0.024241665,0.010114699,0.014326962,0.06982669,-0.024638893,0.056214027,-0.006058297,-0.01211564,0.026383013,-0.0042147646,-0.004037343,-0.0031483711,-0.038652968,0.0771395,0.068824105,-0.10038119,0.012539212,0.03357936,0.04476163,0.005600165,-0.075936556,-0.07421517,-0.016196411,0.056058217,0.029501392,-0.013715502,-0.058418285,-0.03371925,-0.05940582,-0.033045463,0.031188598,-0.069287136,-0.049957253,-0.045632865,0.04109419,0.112239294,-0.06985115,-0.06165268,-0.030992754,0.0030090453,-2.0997317e-33,0.07092716,-0.048676267,-0.04037461,0.010448648,-0.06875796,0.027958924,-0.05178781,-0.009800847,-0.025514403,-0.0015929777,0.06104077,0.0195106,0.02285465,0.00025700603,-0.0014244852,-0.041452143,0.07553163,0.06607235,0.01716283,-0.016365852,0.042268112,0.08886471,-0.070042334,-0.06679807,0.01935739,0.060593054,-0.08897607,0.15099674,0.06286821,0.02118177,0.024632106,0.031353034,-0.09106515,-0.08628315,-0.030094765,0.05210683,-0.017538825,-0.0124475295,0.028007787,-0.025513573,0.01893834,-0.01150099,-0.049922343,0.06515325,-0.03917489,0.022237476,-0.058699116,0.06440848,0.07081779,-0.0090786135,0.000807404,0.040370967,-0.055466905,-0.0017007394,-0.0397696,0.06253708,0.03482072,0.047112666,-0.07334519,0.021516271,-0.018391667,-0.00604635,0.06609816,0.0051889056,0.035781737,0.090148084,0.009176913,0.09768803,0.047674596,0.02861515,-0.006059996,0.06377706,0.11100289,0.082854025,-0.014879263,-0.0015732234,0.021315087,-0.048820402,-0.012542317,-0.05797599,-0.012582686,-0.02203375,-0.021004423,-0.078482985,0.025028432,-0.06111067,0.0419745,0.07485412,0.047622368,-0.0058631976,0.020250034,-0.05856154,-0.038073514,0.014179264,-0.021567592,-3.7897955e-08,0.03423342,-0.040446553,-0.029803945,-0.052645624,0.031050213,0.011021725,0.02421026,-0.005110797,0.09463815,-0.054624166,0.010136133,0.112658985,-0.016484348,0.00398375,0.05647704,0.00012456863,-0.0006744645,-0.03414319,-0.05980282,-0.019226868,-0.033599842,-0.055583775,-0.10112554,0.0014215992,-0.0033666957,-0.024691427,0.045078162,0.014972835,0.0050862017,-0.030500287,-0.024591668,0.03131369,-0.0027782174,-0.02288643,-0.04378438,0.0807468,-0.050005753,0.010135514,0.026091065,-0.014290633,-0.020140534,0.018616144,-0.12753357,0.018416714,-0.032931667,0.019171411,-0.07001511,-0.030181974,-0.032624822,0.020234305,0.008229773,-0.016423143,-0.048135187,0.019692855,-0.07535517,0.046062987,0.05441156,-0.03113298,-0.0433413,-0.016042741,-0.06592448,-0.0034094478,0.15366212,-0.0674676 +1.14.13.163,The enzyme catalyses a reaction in the nicotine degradation pathway of Pseudomonas species. One of the enzymes from the soil bacterium Pseudomonas putida S16 contains an FAD cofactor [2].,384,0.99999994,-0.031218283,0.019660229,-0.07292225,-0.061327793,0.06418614,0.10562965,-0.10549422,0.043048214,0.012093966,0.009920269,0.0048995856,-0.032002438,-0.099455565,0.018982878,-0.001637535,0.03940178,-0.080448404,0.06592593,0.009792235,-0.00129098,0.0528426,0.09515997,-0.04898991,0.023270408,0.023708917,0.05317914,-0.027652713,-0.061281957,0.010520059,0.043620825,-0.053878866,-0.022005558,0.012068879,-0.0719898,0.049016036,-0.01879991,0.00053715287,-0.022695385,0.07884265,-0.026859844,0.03645885,0.0802621,-0.018578766,-0.049839035,-0.011056133,0.03649968,0.058431663,-0.0071170875,0.013701671,-0.0786531,-0.02552594,-0.005856816,-0.010756783,-0.0028431967,-0.01579344,0.033040877,0.00525016,-0.04450233,0.009847377,0.025925033,0.06296623,-0.05510394,-0.010398805,0.0011968857,0.07171669,-0.058137074,0.012411186,-0.037459955,0.006646345,-0.04894792,-0.08665569,-0.061955214,-0.004204618,-0.007652598,0.045302466,0.014430701,-0.12032488,-0.031094668,0.08847508,-0.038099617,0.045789316,-0.045825716,0.04760621,0.11310486,-0.0067250584,-0.07392301,0.06459483,0.0032933003,0.094128214,-0.026069822,-0.0016111212,0.006232561,-0.008450553,-0.007106241,-0.14293934,0.054868467,0.039449878,0.045506578,0.010705409,-0.03404876,0.016862158,0.06379522,-0.029216595,-0.10150387,-0.020513419,0.03755828,0.0073173475,0.09469034,0.062627696,0.04210721,0.012523175,0.012387742,-0.0016087581,-0.04708941,-0.00018552541,0.06937833,0.06210258,-0.055126037,-0.06408452,-0.044279978,-0.0033554235,-0.0694423,0.022176763,0.07699358,0.027016796,-0.05010743,-0.0989494,1.0608454e-33,0.026427735,0.04519682,-0.033457864,-0.039549787,0.07758811,-0.032137416,-0.05174689,0.0055919345,0.034537677,-0.040878028,-0.015374938,-0.08917197,-0.041472133,-0.0056662858,-0.021514952,-0.016617255,-0.02547668,-0.07960606,0.09004647,-0.041335132,0.040579047,0.0462849,-0.03843583,0.07175614,0.039359186,0.046119493,-0.02020085,0.0081381295,-0.075988345,-0.013762911,0.05617006,-0.019126562,-0.15220864,-0.091010295,0.032011032,0.023376852,0.009588504,0.015855685,-0.060564768,0.04573278,0.08020511,0.03151599,-0.0006047314,-0.044428468,0.059980504,-0.085469395,-0.049474154,0.13661042,0.08897778,0.10909076,-0.06703362,-0.11635236,0.064521834,0.045771588,-0.08875946,0.017414227,0.004972141,0.0065802042,-0.0061083985,0.03444543,0.014666125,0.017181702,-0.028873855,0.09479607,-0.03856895,-0.035449054,-0.011972952,-0.07624436,0.061919466,0.084892526,-0.085678875,0.043713417,-0.0074635134,-0.011432286,-0.018699365,-0.15199837,-0.066920795,0.04609658,0.015909135,0.05343434,-0.0072385506,-0.06619908,-0.051103074,-0.035741724,-0.040122837,-0.018678384,0.0013728602,-0.048732176,-0.0180724,0.037578788,0.033606023,-0.06563642,0.07113839,0.10901058,-0.0070924596,-1.4049283e-33,0.02001033,-0.0753861,0.110588215,-0.04122304,-0.01668339,0.04656039,0.0135063855,0.00580804,0.024303889,-0.028694896,-0.011335601,0.004961081,0.12143313,0.041856427,0.015368636,0.04594178,0.040071912,0.0016919017,-0.009662924,-0.021078862,-0.04404425,0.07710634,-0.055487093,0.040444534,0.03327083,0.03841934,0.018880464,0.054289594,0.04336769,0.02334072,0.037099965,0.06518067,-0.05022447,0.0036611466,-0.04848958,0.02559688,0.0021307496,0.022285176,-0.0028442177,-0.012838855,0.06686403,0.017377451,-0.040480666,0.053683262,0.01026923,-0.0038618785,-0.11040112,0.025315685,0.035589576,-0.06027846,0.05604402,0.010161286,-0.08654659,0.024529666,0.04550935,0.047512572,-0.03576761,0.015399984,-0.06574793,-0.037169397,-0.040155437,-0.06808203,-0.0406278,-0.015141603,0.08709032,0.024289362,-0.033808667,0.06606196,0.007031766,-0.013338897,0.052590482,0.06513688,-0.0071371384,0.038152765,-0.06513449,-0.05542358,-0.05457881,-0.019879254,0.053203456,0.019827373,0.014771694,0.022124425,0.0017028995,-0.045718107,-0.033359256,-0.034393787,-0.0049271244,0.13481018,-0.047426928,0.012200556,-0.0022217308,-0.04710792,0.042424683,0.03565045,0.00668544,-2.8463816e-08,0.041040387,-0.05487409,0.06880112,0.015845135,-0.0003152627,0.08112886,0.04307304,0.015956802,0.026364142,-0.042784553,-0.036910478,0.061144922,-0.008276208,0.024658276,0.03870982,0.011536822,-0.10183476,0.02572536,-0.06734938,0.004464031,-0.095129415,-0.014012372,-0.05279845,0.03984091,0.0012747456,-0.028463267,0.04790818,0.0065743118,0.023868185,0.007296473,-0.0042999135,-0.02659289,0.024631483,-0.020327419,-0.0854351,-0.02108964,0.057695065,-0.066085026,-0.0027845034,0.004413079,0.015838988,-0.038601965,-0.121231556,-0.029991202,-0.00031108162,0.0016063338,-0.029744957,-0.012185334,-0.034575965,-0.004152208,0.0661654,-0.009850263,0.017891604,-0.01379033,-0.11911903,-0.06464508,0.025700245,0.013706407,-0.0057974127,-0.009087598,0.06359601,0.026061399,0.14513253,0.015202294 +1.14.13.164,"The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary carotenoids in insects. The enzyme accepts different all-trans carotenoids, including beta-carotene, alpha-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule.",384,1.0,-0.017634537,-0.04207851,-0.06346691,0.062461257,0.036483977,0.034666102,0.009577613,-0.021670131,-0.004026596,-0.00089306035,0.06594624,-0.07245767,-0.08289593,0.039746255,-0.040510703,0.064601466,-0.05928241,0.04360386,-0.01967843,-0.06639578,0.08765964,-0.06865505,-0.020961711,0.009582042,0.010466002,-0.025962206,0.047697783,-0.07191515,-0.044457506,-0.096601404,-0.065952815,-0.046076782,0.033825316,-0.017794177,-0.00960103,0.032981563,-0.025294181,-0.0720638,-0.0035253223,-0.011245509,0.052734423,0.009816556,-0.07557799,0.021053052,-0.028595453,-0.023527147,0.014249816,0.11358056,0.03315574,-0.04122447,-0.09180359,-0.09622389,-0.093899414,0.016563402,-0.040625807,0.06730988,-0.045724757,-0.012375984,0.04466226,0.023332775,0.09019605,0.023243407,0.013221381,-0.020302026,0.07098275,-0.06345245,-0.04533911,-0.076827966,0.01697992,-0.08216649,-0.003768981,-0.05711555,0.012787889,-0.05358413,-0.03680516,-0.013672465,-0.012000915,-0.009124753,0.020258611,0.014418863,0.020142235,-0.010386209,0.0129722105,0.09311513,0.11053122,0.012761938,-0.026361516,0.061879832,-0.012024712,0.04621311,-0.003616233,-0.063643284,-0.05735522,0.013546809,-0.028378176,0.006084399,0.043899067,-0.07983411,0.024470722,-0.041338045,-0.026363185,0.038375378,0.02123265,-0.10283724,-0.04986377,0.004620157,0.024208266,0.071192764,0.015688322,-0.010282979,0.024031295,0.06513839,0.05402567,0.045207117,-0.07906332,0.023932302,-0.0695719,-0.043914676,0.022394875,0.10968999,0.02015413,0.058842577,0.03698789,0.050191425,0.01854715,-0.014195257,-0.06719295,2.8642393e-33,0.02334433,0.060956884,-0.030694615,0.031470437,0.021002037,-0.03146266,-0.023411844,0.014045053,-0.0831789,-0.048392475,-0.09287489,-0.046814375,0.058872163,0.03915576,-0.012173923,-0.0006605174,-0.013323965,0.004033379,0.10742206,-0.008388961,-0.072220616,0.024277208,-0.06503361,-0.048089266,0.019905802,0.08618415,-0.082590215,0.029170208,0.011057461,0.037746906,0.08638054,-0.008931235,-0.0456761,0.063253425,0.13890615,0.0676588,0.040924713,-0.07541643,-0.10687138,0.051381834,0.016913762,0.012315313,0.00953521,-0.029242946,0.038326513,-0.05039653,-0.06169283,0.058066744,0.06953578,0.060808778,0.015321253,-0.001789154,0.103689246,-0.10878461,-0.054813754,0.013856112,-0.011923017,-0.021004517,-0.028934626,-0.022511175,-0.051884636,0.05662761,-0.057730842,-0.008702509,0.002086671,0.04946337,-0.06890841,-0.08127377,-0.06425025,0.017076617,-0.033073433,-0.03355442,0.026870763,0.015950857,-0.0087108975,0.030645745,-0.005390977,0.03665725,0.03130084,-0.038260628,-0.05587296,0.009997232,0.0609687,-0.06468746,-0.023534385,0.03682169,-0.019435858,-0.012413167,0.062444262,0.07054068,0.001395317,-0.053201858,-0.012533481,-0.035456087,0.045873743,-2.8891487e-33,0.0036809554,-0.13562639,-0.0022413866,-0.031831115,-0.06104398,0.05530531,-0.0747037,-0.06149036,0.05103142,0.02058147,0.0034944236,0.045584194,0.018082518,-0.031417284,0.02688623,0.016691785,0.057323363,0.067759946,-0.001048504,-0.028216999,-0.0822466,0.1317129,0.01899952,-0.0061653364,0.03577315,0.058721706,0.006582962,0.10244024,0.082891196,-0.024656681,0.028823668,-0.059170257,-0.016569557,-0.027465422,-0.008951401,0.069063425,-0.111338936,-0.00832344,0.098053865,0.12599145,-0.0359013,-0.010459635,0.010065704,-0.017330742,0.06601559,0.03029159,-0.032009825,-0.010150086,-0.01330355,-0.057272214,0.052258797,-0.018525623,-0.05997606,0.018883213,-0.009938214,0.052136023,0.0563361,0.06558764,0.039133232,-0.07284498,-0.0059648487,-0.089585885,0.06148643,-0.048356846,0.016938645,0.035271097,-0.012094795,0.078597866,0.069512,-0.020913754,0.087668836,-0.011538371,0.034529127,0.0599456,-0.06803086,-0.049268752,-0.0030294817,-0.010960487,0.014287027,-0.039222714,0.036703203,0.0068217167,-0.0025691616,-0.0023099168,0.01417573,-0.013744576,-0.006967297,0.08096679,-0.006889961,-0.02722177,-0.018030083,-0.030165689,-0.045617856,0.06763467,0.11994582,-3.8134612e-08,0.07976696,0.0050594965,-0.007143275,-0.03625601,0.014122978,3.6271194e-05,-0.008294287,-0.01784232,0.019447248,-0.022979679,-0.026547376,0.030984946,0.08186192,0.014623522,0.042165764,0.021793153,0.018859033,0.024810566,-0.021957299,0.06145846,-0.10846851,0.029627878,-0.097386844,0.017308403,0.002722519,-0.0679954,0.048849363,0.017107442,-0.03887191,0.021969218,0.033930246,0.052029997,0.048503574,0.034984928,-0.11961869,0.012343469,0.0027545595,0.005385321,-0.012359703,0.0046822564,0.005308376,-0.04414149,-0.04060608,0.027900694,-0.060445234,-0.029240584,0.063883476,-0.03729457,-0.039438464,0.080024555,-0.04031357,0.0022024168,-0.024194054,-0.04979264,-0.10524677,-0.060812615,0.062173374,-0.08067228,-0.030365257,-0.069911554,0.055782568,0.09047447,0.14411631,-0.040857904 +1.14.13.165,"Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. Most of the bacterial and archaeal enzymes consist of only an oxidase domain and function together with bacterial ferredoxins [1-2]. The enzyme from the delta-proteobacterium Sorangium cellulosum also includes a reductase domain that binds FAD, FMN and a [2Fe-2S] cluster [3]. The similar enzymes from plants and animals use only NADPH as acceptor (cf. EC 1.14.13.39).",384,1.0,-0.057857167,-0.062259134,-0.1514586,0.017105676,0.109493986,0.044074785,-0.06191637,0.035899293,0.103532106,-0.059766468,0.019232912,-0.051932886,-0.09615222,0.019043116,-0.029044151,-0.053704303,-0.07449449,0.0052987942,-0.00011753422,-0.0121802045,0.01463342,0.052559223,-0.011621853,-0.039327532,-0.009812436,-0.0020800086,0.031751763,-0.042169683,-0.036023203,-0.042438652,0.00662159,-0.011463903,0.043587316,-0.0044980696,0.0095462715,0.08715164,0.02784816,-0.0739164,0.022985434,-0.035908844,0.048607353,-0.01564525,0.040551476,-0.049248006,-0.069268875,0.0037631667,0.06358211,0.019797914,0.038185205,0.00966556,-0.01806522,-0.035376195,-0.033322703,0.07396632,-0.03397111,0.06540907,0.08209454,-0.025307562,0.045991592,-0.054946166,0.014706438,-0.05686851,0.03197532,0.015606058,0.0146870185,-0.059768137,-0.00684376,-0.03494178,-0.09868215,-0.07134658,-0.055788223,0.024499513,-0.0078967,0.056329496,-0.009221954,0.12005612,-0.042719062,-0.056662656,0.051799793,-0.02301308,-0.008353924,0.037293155,0.0418388,0.12791112,0.016374983,-0.012650162,-0.02752755,0.009170846,0.00024219046,0.010701439,0.061430648,0.02257912,0.030920634,-0.06383054,-0.08601877,0.023305932,0.07733566,0.013945857,-0.001647252,-0.060265966,-0.0580639,0.063578814,0.00059984054,-0.08774853,-0.021051655,-0.0199534,-0.05408073,0.10389305,0.100510105,0.008220688,0.027139228,-0.053550422,0.054469783,-0.019402435,0.007842196,0.049006674,0.03082959,-0.05503305,-0.092987716,-0.06672966,-0.030590383,-0.004318068,0.039292794,0.052776385,0.03508567,-0.01957797,-0.14708447,3.4456322e-33,0.11181607,0.0041894596,-0.028152099,0.00860768,0.019315936,-0.012235816,-0.05688425,-0.04290762,0.018420158,0.021135626,-0.079273,-0.03585897,0.07034243,-0.0641244,0.03440218,0.002316853,-0.03503731,-0.06493755,0.040271346,0.04273212,0.06534806,0.053022012,0.0095589375,0.004801733,0.050708886,0.03468661,-0.032694947,0.02365216,0.045206502,-0.014741608,0.070384026,-0.10136076,-0.11904041,0.019547898,0.13980857,-0.021936143,-0.0073896646,0.010243318,-0.10559688,-0.028618533,0.014178338,0.053931464,-0.067257725,-0.033021558,0.13248609,-0.11124636,-0.029981317,0.119233966,0.041767772,0.10840107,0.0036892493,-0.032469094,0.09771502,-0.02754167,-0.048845682,0.024254125,-0.04135023,0.0692573,0.033413038,0.08216726,0.050798647,0.014928339,-0.039397735,0.09737023,0.02848569,0.08789835,-0.007365977,-0.036037914,0.04281607,0.0805703,0.003564086,0.020952031,0.047686957,0.038657438,-0.038557794,-0.016066214,-0.049297173,-0.08121646,0.05799428,-0.040562466,-0.000210527,-0.03319774,-0.029378375,-0.006983732,-0.05136632,-0.00082247343,-0.053044587,0.0070197177,-0.049871344,-0.043669455,0.11786639,-0.04767862,-0.01637458,-0.033106003,0.006293864,-2.7122514e-33,0.098405145,-0.097249046,0.040423207,-0.0983674,-0.017946748,0.08863917,0.035019524,-0.059548635,0.00055409496,-0.046874996,0.08930581,0.03624763,-0.035014562,-0.0049510943,0.03399888,0.008248059,0.008048447,0.025485141,0.033968795,-0.023137905,-0.028538551,-0.0031870247,0.018325552,0.030592605,0.039719913,0.028350335,-0.044121716,0.042299323,-0.0381817,-0.005966311,0.004819274,0.047681525,-0.065223455,-0.08870598,-0.04827114,-0.046373866,-0.06195119,-0.029653417,0.07184292,-0.02783846,0.020203372,-0.024448832,-0.045531258,0.07576303,0.046395812,0.026926203,-0.13656537,0.023810074,0.008634524,0.028466843,-0.03949628,-0.052144405,-0.025801048,-0.054154865,0.05534328,-0.00838177,0.07134885,0.052184355,-0.0039890674,0.0071074995,-0.0011503865,-0.039881878,0.07654951,0.10071611,0.009156492,0.045696866,0.035553873,0.07006943,0.03247561,0.026729241,0.07969242,-0.0073900754,0.039517716,0.02094523,0.010667722,-0.054355204,0.05909615,0.044153858,0.043940347,0.0051638857,-0.018951252,0.016365632,-0.028656151,-0.072163425,0.04720926,0.01564668,0.009643361,0.07615559,-0.007615156,0.03396558,-0.026259273,-0.0070317676,0.02452465,-0.047182262,0.044410463,-4.1433335e-08,-0.016233798,-0.027644161,0.055908352,-0.074835025,0.011856593,0.028308049,0.052202627,-0.008654394,-0.016104668,0.0071156663,0.023039812,0.097899504,0.00030187724,-0.041047722,0.06368336,-0.0086366385,-0.0021582255,0.016643433,-0.051599327,-0.012862518,-0.018338393,0.015849488,-0.09926277,0.031084284,0.016580194,-0.108207844,-0.050771527,-0.039793104,0.021639347,-0.0038829974,-0.004656549,-0.021497758,0.044490784,-0.06561523,-0.050549354,0.009218211,-0.00748705,-0.013632181,-0.045637794,0.041271225,-0.036035493,-0.021094725,-0.06299923,-0.07045783,-0.0029746792,0.07637593,0.03938778,0.04988243,-0.021683523,0.007019675,-0.01904203,-0.041575156,0.024996832,-0.052938722,-0.10184381,0.049258314,0.02364865,-0.026311897,-0.024850536,0.012724725,0.006177574,-0.017497161,0.09456978,-0.030297125 +1.14.14.13,"Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. FMNH2 is used as a free cofactor. Forms a complex with a dedicated NAD(P)H:FMN oxidoreductase. The enzyme is not able to hydroxylate free substrates, activation by the acyl-carrier protein is mandatory. +Octanoyl-S-[BtrI acyl-carrier protein] is also accepted.",384,1.0,-0.033556566,0.0015571424,-0.14516221,-0.0032276674,0.088117376,0.06306153,-0.09335656,0.06414398,0.045284048,-0.012886505,0.0722555,-0.013773931,-0.033398934,0.11325629,-0.05032021,0.019635994,-0.10390294,-0.0067829317,0.0075323777,-0.021021035,0.029784463,0.009506493,0.01394484,-0.0476468,-0.036381286,0.055135965,0.003557142,0.05080679,0.04777462,-0.06004891,0.0037209862,0.011117551,0.024503222,-0.04844571,0.019794064,-0.004598562,0.047134187,-0.006142538,0.07662917,0.035420377,-0.078072265,-0.02509286,-0.03214532,-0.024591733,-0.016743373,-0.06278261,0.06959613,0.06257495,0.020384863,0.010314909,-0.028505161,0.045798037,-0.071475185,0.061234944,0.0377516,0.028185422,-0.06522411,-0.047277644,-0.11205137,-0.0017219558,0.04373185,0.02644987,-0.022058755,-0.011605577,0.01266518,-0.055941787,-0.05218592,-0.04274183,0.022571353,-0.013121762,-0.03938531,-0.079776525,0.03227498,0.027458675,0.06344855,0.020506458,-0.01615988,-0.017925732,0.011659596,-0.027360514,0.018869348,-0.008234875,0.0003082203,0.11383582,0.09713756,-0.053267494,-0.00267946,-0.0036233638,0.045844343,0.037437383,0.0037145666,-0.005341851,0.021488888,-0.06161083,-0.09138611,0.008872231,0.06314103,0.09209751,0.0028120582,-1.0081309e-06,-1.2691613e-05,0.012498049,-0.05286098,-0.08166067,-0.0718954,-0.014819867,0.012731314,0.11069255,0.048959937,-0.02599829,-0.037753545,0.02872108,-0.014146113,-0.02118882,-0.018473303,0.08022174,0.0067931646,-0.064691335,-0.08112527,0.021420354,-0.027419291,0.010210061,-0.033056796,0.112823404,-0.031900957,-0.019077979,-0.1302362,2.027943e-33,0.03882266,0.14043844,-0.03369515,-0.024139471,-0.042400967,-0.012960189,-0.04605582,0.0077136937,-0.029967602,0.022081966,-0.07348247,-0.035838824,-0.010844453,-0.017184088,-0.008530528,-0.11275331,-0.019809864,-0.04455596,0.049236704,0.042008862,0.04703662,0.0923991,-0.0059494344,0.011279876,0.06619057,0.045168433,-0.0125008905,0.0045107114,0.04495011,0.026782095,-0.008371596,-0.08926233,-0.0871647,-0.032934293,0.005860436,-0.02739055,-0.083235525,-0.012718646,-0.022096844,0.038976487,-0.019755501,0.03962862,-0.07072854,-0.05701389,0.042098742,-0.015685312,-0.0333279,0.08774762,0.038827706,0.032976177,0.039117675,-0.076502144,0.048152864,-0.008263805,-0.026422119,0.004344104,-0.08748393,-0.0034867087,0.00847781,0.10445169,-0.0055599026,-0.018408384,-0.01733832,0.079292,-0.041947484,-0.06147223,-0.023440912,-0.043323573,0.021254003,0.10094447,-0.051130947,0.0438485,0.087590635,0.013916943,0.028179837,-0.024064993,-0.036984123,-0.012351449,0.106068075,0.024472909,0.0071725664,-0.028516045,-0.022391725,-0.028712561,-0.022586396,-0.012506296,-0.04507198,-0.044110984,-0.046742585,0.07463684,0.016572287,-0.07421741,-0.011338952,-0.044225965,0.055010542,-3.6030173e-33,0.042498793,-0.12110091,-0.011514013,-0.14374964,-0.06781565,0.10609423,0.020403257,-0.060593996,0.018608857,-0.005678146,0.01989833,-0.014470494,0.009434102,-0.07618608,-0.01168031,-0.04852687,0.01078385,0.041972425,0.0451706,0.022523724,-0.029262163,0.055695876,-0.021783665,0.036551826,-0.013821018,0.08628489,-0.017602835,0.080627486,0.09155716,0.11658139,-0.021193016,-0.016431183,-0.05465546,-0.092784345,0.041245464,0.08372853,-0.068616144,0.0437569,-0.042053424,-0.011383148,0.020471327,0.010313439,-0.009638449,0.06777248,0.030178037,0.03661216,-0.113845,-0.012290781,0.08373447,-0.08001066,0.035776652,-0.037551943,-0.048741307,-0.020065948,0.034183454,0.015444361,-0.019346932,-0.041806996,0.041574236,0.0039232364,-0.048216917,-0.05061326,-0.036937807,-0.025162714,0.020784007,0.01335554,0.02036155,-0.00020083791,0.04233357,0.034978382,0.06714063,0.013020693,0.023112854,0.018395754,-0.028483301,0.00050666416,-0.03794232,-0.019310618,-0.028839033,0.025762908,-0.021361992,-0.041365765,-0.014041697,-0.046711754,-0.025878431,-0.055598974,0.040633194,0.10855237,0.020414254,0.024551196,0.056048535,0.05823904,-0.005724607,0.03231808,0.0037063765,-4.2297128e-08,0.033752516,-0.1351548,0.11077718,0.012168345,-0.02436894,0.08606457,0.004963866,-0.060709104,0.03259574,0.022969611,0.031326544,0.105191916,0.02046193,-0.0070962477,0.019688716,0.017307399,0.007901985,0.046291333,-0.00817863,-0.039905265,-0.13124196,0.026195964,-0.107982755,0.0041087326,0.001612576,-0.041337218,0.04982389,-0.026646165,0.044642683,-0.043237742,0.041051995,0.017613059,0.008234608,0.035318814,-0.08958178,-0.061960705,0.008296872,-0.039597686,-0.04375942,-0.02241733,0.041433405,0.040229093,-0.08694392,0.022443464,0.059385195,0.032233644,-0.012492223,0.0077881976,-0.03968716,0.021318225,-0.0022719714,0.0025477533,-0.012439433,-0.032951366,-0.08717864,0.063986376,-0.0021123393,-0.040695764,-0.016941722,-0.07777252,-0.028709339,0.012103853,0.1896687,-0.0037363437 +2.1.1.258,"Catalyses the transfer of a methyl group from the N5 group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. Involved, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.",384,0.9999999,-0.034036268,-0.028833136,-0.11127736,0.0074729645,0.0849244,0.028163755,-0.09285646,-0.05778819,-0.031870663,-0.0082461005,-0.0016993093,-0.10333039,-0.035012543,-0.056312446,-0.09282115,-0.016519563,-0.065712504,-0.028300142,0.03630228,-0.016081754,0.008878674,0.08937187,-0.07085586,-0.029059049,0.014918043,0.03238618,-0.008408656,-0.029744212,-0.02135542,-0.08174703,0.02371803,0.028797612,0.04931302,-0.03995995,0.04049507,0.12348544,0.01868435,-0.06646189,0.11687411,0.057631373,-0.0085037155,0.034144077,0.05511249,-0.008427475,-0.05446266,0.0058089895,0.005506255,0.029101253,0.05623917,-0.095048636,-0.06875452,-0.037738442,-0.06204436,0.0019521724,0.00597044,0.07182812,0.058776893,-0.07275788,0.032113194,-0.03498319,0.036341567,-0.003165934,0.007993331,0.023388427,0.009677101,-0.015654813,0.051998008,-0.100390635,0.028463358,0.017878387,-0.10587403,-0.027794592,-0.02279137,-0.015470359,-0.028325696,0.01933102,-0.031761233,-0.08211104,0.07741515,-0.012701673,-0.047953315,0.030706804,0.0024233449,-0.03773959,0.026000312,-4.4532375e-05,-0.038113862,-0.010430365,0.073279805,0.063461155,0.0065197144,0.012145809,0.0879103,-0.051709436,-0.1309595,0.049426407,0.08527847,0.07019885,0.044181008,-0.059220467,-0.01893957,0.09089831,-0.017301695,-0.061892148,-0.030149523,-0.056797482,0.03593277,0.2126734,0.038687054,0.014723806,-0.039902978,0.041590154,0.044445697,-0.060857877,-0.0040226732,0.07131031,0.056414615,-0.073943265,-0.07140811,-0.0005975519,-0.008728733,-0.029141806,0.046044733,-0.03959109,0.03338791,0.017332314,-0.083986424,3.904501e-33,0.108265124,0.06904265,0.01434445,0.030302787,0.019815177,-0.04877985,-0.13287649,-0.023100914,0.0654764,0.026035668,-0.040843148,-0.040301632,0.051912755,0.009567883,-0.060703203,0.021423863,-0.07656266,-0.055895958,-0.006231408,0.021154441,-0.041693628,0.061631434,0.014415737,-0.024148373,0.042579543,0.035590366,0.024955688,0.01986755,0.03225076,0.012468682,-0.011326496,-0.051048025,-0.10290906,-0.03249159,0.06724581,-0.024144098,-0.01707376,0.016698554,-0.050634634,0.020689039,0.056926057,0.09470488,-0.041404307,-0.044314772,0.031278454,-0.00210418,-0.047147844,0.10024362,0.006163221,0.0380244,0.004052399,-0.003927115,0.061375488,-0.024816288,-0.086029686,0.015443421,0.0054097017,0.016108073,0.028046265,0.047325067,0.02219199,0.017942123,0.0073649483,0.06149759,0.011626625,0.016918946,0.046292305,0.028750453,0.09781205,-0.0028541554,-0.018942462,-0.043680243,0.061053924,0.07815391,-0.037395608,-0.0418576,-0.055645004,-0.09509991,0.058741786,0.035258204,0.02676329,0.023701161,0.040009674,-0.056230977,0.01348144,0.03231767,-0.036328766,0.026292723,0.004501397,-0.013239039,0.082686126,-0.053374693,0.041066624,-0.008056856,-0.018632984,-4.4897404e-33,0.09599289,-0.11107287,0.03007833,-0.081419766,-0.051713765,0.03465893,0.014348675,-0.05593444,0.019511364,-0.01592552,0.10471564,0.058110796,0.043550305,-0.032313824,0.02219226,-0.07312239,0.0043140203,0.04880439,-0.026375331,0.021926094,0.070958644,-0.033715297,-0.02040235,-0.008949845,0.08094521,0.07108343,-0.070123136,0.019205423,0.025451723,0.059065647,0.0626556,0.006190375,-0.01331438,-0.044389244,-0.047869053,0.04974481,-0.061790455,0.05978468,-0.035251386,-0.008120159,-0.005826942,0.028637499,-0.035331424,0.031357747,0.030773884,0.008200021,-0.12253748,-0.0567576,0.0026839098,0.04053922,0.0017452055,-0.0249533,-0.03640977,-0.04297333,0.0025924826,0.058361556,0.056869775,0.07238897,0.029201366,-0.032233126,-0.11865084,0.01768581,0.040830724,-0.021203633,0.086684786,0.069383435,0.0023869257,0.03330185,0.047961574,-0.02182596,-0.016473493,0.06744966,0.019858032,0.016155116,-0.0089050215,-0.021358794,-0.047053725,-0.011344822,-0.070025116,0.021967223,-0.0043821316,-0.03035297,0.020678427,0.013862001,-0.09125688,-0.08175933,0.049845483,0.009155398,-0.07421348,0.013113176,-0.044855077,-0.047374174,-0.0127715925,-0.0034059,0.0030846964,-3.952541e-08,-0.03868835,0.0076158457,0.06268041,-0.042555414,0.06713344,0.086559184,-0.057440598,-0.048574653,0.08200577,-0.024081085,0.016914953,0.04034221,0.09845962,0.0695726,-0.07563912,-0.019975126,-0.0775944,-0.028787987,0.0019095251,0.0022398643,-0.06832895,-0.018501177,-0.046935454,0.056768138,0.062609814,-0.08124054,0.0049984623,0.06390595,-0.01237826,-0.031792056,-0.03270758,0.065906055,-0.0027964069,0.03663972,-0.057595883,-0.04449661,0.0018149114,-0.069446266,-0.060794502,0.029709263,0.014144154,0.039668575,-0.10471983,0.020267632,0.027596164,0.008504226,-0.009047096,0.047855094,-0.05651924,0.0017859363,0.0661922,-0.048171002,0.0063125156,-0.05342144,-0.041198425,0.006650464,0.014087854,-0.05078491,0.039854717,0.013496182,-0.0074043605,-0.033583827,0.0998001,-0.08150567 +2.1.1.259,"The enzyme methylates a conserved lysine in the C-terminal part of higher plant fructose-bisphosphate aldolase (EC 4.1.2.13). The enzyme from pea (Pisum sativum) also methylates Lys-14 in the large subunits of hexadecameric higher plant ribulose-bisphosphate-carboxylase (EC 4.1.1.39) [2], but that from Arabidopsis thaliana does not.",384,1.0,0.0089192735,-0.060260847,-0.069971226,-0.048104145,0.075861886,0.114165336,-0.080400474,0.018629551,0.03984723,0.017099185,0.05864405,-0.008857112,-0.016566262,-0.057334047,-0.015251607,0.018865101,-0.1091676,-0.016945943,-0.03750351,-0.05287951,0.0947288,0.028749464,-0.028718341,0.022948831,0.037349988,-0.026276046,-0.004847213,-0.06746169,-0.015698727,-0.05566044,-0.07270973,0.010911889,0.09321074,-0.012321256,0.07484941,0.14797662,0.012966116,-0.12747772,0.049694348,0.0107223485,-0.0033593283,-0.025763122,-0.002116253,-0.044367783,-0.05333886,0.02705612,0.041933578,-0.013190281,-0.01288578,-0.032095183,-0.004298653,-0.044631388,0.034850538,0.0026315728,-0.004046388,0.0042500063,0.012820981,0.04488446,0.034466777,0.05449724,-0.035436653,0.039810292,-0.035988007,-0.008362068,0.027934616,-0.022306649,-0.03086264,-0.04768343,0.021039693,-0.06687138,0.027326493,-0.071956865,-0.05779444,0.026877722,0.025887333,0.036426004,-0.006862661,0.0011823637,-0.008214592,0.009278774,-0.0016566773,-0.021773733,0.022577325,-0.0071211,-0.0010668613,-0.051441353,-0.023464536,0.07079256,0.04611674,-0.029441068,0.04348007,-0.00790613,0.00067843543,0.0159817,-0.037762113,0.026490808,0.003658922,-0.03920549,-0.03477374,-0.05823751,0.06760149,0.071516424,-0.0644081,-0.035725374,0.016639182,0.07393281,-0.0006424549,0.04840311,-0.042258333,-0.020313181,0.02440227,0.047246546,0.016400797,-0.00816682,-0.016016142,0.034733925,0.012209873,-0.0982188,-0.009520881,-0.0793287,0.020263126,-0.03873799,0.07474148,0.0931947,-0.049698353,0.0108981645,-0.19166741,3.2326142e-33,0.07666481,0.06761919,0.021137806,-0.11242445,0.013060665,-0.017640777,-0.0038616976,0.048431344,-0.034253903,-0.07304771,-0.12063626,-0.046651963,0.03910767,-0.03661629,-0.049828935,-0.030750742,-0.088904604,-0.04301096,0.052756064,0.0043324563,-0.047920622,0.028044337,-0.050784666,0.047968287,0.0010933897,0.0387362,0.06353488,-0.037885398,0.013737391,-0.019111264,-0.0031713771,-0.07850087,-0.057366,0.047212247,0.042765547,0.003063565,-0.018017089,0.0025516793,-0.022651,0.09037566,0.059316553,0.039780557,0.06850021,-0.03556712,0.05128902,-0.021318309,-0.036266886,0.051062506,-0.0068357033,0.07850109,0.06377866,0.023031643,0.0559682,-0.037295982,-0.076740034,0.0015787856,0.013264922,0.02463799,0.0068565137,0.059545573,-0.0034020292,0.024147505,0.06130201,0.030413052,-0.05041287,0.007486298,-0.13541068,-0.052125905,0.0118707055,0.14925542,-0.067289785,-0.059226774,0.097098984,-0.02247446,0.06830038,-0.039997235,-0.11812488,0.011190091,-0.019269334,0.057660352,0.07227793,-0.0031334036,-0.03908535,-0.007668478,-0.069969304,-0.06849572,0.04324663,-0.053071577,-0.06588805,0.033521656,0.0070913304,-0.03206235,0.017311359,0.08565389,-0.022262026,-3.9446924e-33,0.0733581,-0.071958765,0.11728953,-0.08906757,-0.035945725,-0.02178204,0.06997142,-0.059703693,0.0143093085,-0.047955118,0.08855053,0.020503953,0.062403936,-0.012607146,0.05286293,0.031901196,-0.015904235,0.11551577,-0.018361796,0.046580143,-0.066681676,0.03862122,0.004635814,0.052856088,0.057969388,-0.013238549,-0.006895815,0.06871685,0.08423032,-0.04220981,0.025981305,0.02080028,-0.05546847,-0.026108032,-0.028913634,0.034717742,-0.07258674,-0.045378078,0.062392153,0.043027773,-0.0070028496,0.019472687,0.03649676,0.040696338,0.033819243,0.010163585,-0.054727875,-0.012154982,-0.05328821,-0.0057582525,-0.012094606,-0.006935287,0.0043015126,0.105162844,0.030221252,0.01052217,-0.008771092,0.12807398,-0.060905766,-0.031238483,0.007915225,-0.06274182,-0.01828867,0.027959358,0.058747176,-0.0040251934,-0.053089783,-0.016373696,0.007888002,0.076486595,0.06784351,0.007459811,0.016544117,0.060956858,-0.038671676,-0.043650396,-0.09207031,-0.049698617,-0.09553587,-0.03145623,0.005747612,0.027314907,0.009203079,-0.056322217,-0.0011459184,-0.08576943,0.016513081,0.09868194,0.015461369,0.030199144,-0.016970672,-0.048629887,-0.050486814,0.021014059,0.0921222,-4.4225185e-08,-0.038706966,-0.035638496,-0.043183047,-0.031461008,-0.011636367,0.012817894,-0.01638429,-0.0125321895,-0.0077386843,-0.00619429,0.002920479,0.032509007,-0.025612764,-0.025352502,0.03521586,-0.011033634,-0.035808127,0.05617692,0.043966196,0.07842038,-0.038249023,0.027592761,-0.08871266,0.0066051516,-0.069237374,0.027234597,0.022483362,0.056396388,0.030945603,0.00849591,0.09457248,0.021878647,0.040542282,-0.096293956,-0.043692265,0.02200077,-0.012023004,-0.0020701739,0.008771841,0.00492124,0.013126891,-0.04633953,-0.08341906,0.030474642,0.0032631876,-0.039041482,0.014956299,0.051047064,0.050735492,0.07017843,0.04814849,-0.013216596,-0.019970661,-0.106204085,0.024343342,-0.05557236,-0.04447304,-0.04328605,0.038177922,-0.042692035,0.017388646,0.015737534,0.18449073,-0.06907259 +2.3.1.199,"This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate [5], while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase",384,1.0,-0.04274228,-0.09025857,-0.019683896,-0.018288245,0.106256664,0.040478222,-0.16548689,0.021184955,0.040968433,-0.08174389,0.12803912,-0.127202,-0.09313651,-0.029618025,0.07021093,-0.03132631,-0.044835377,0.014485984,-0.035926074,-0.061101113,0.07318641,0.057179697,-0.044557992,0.04313053,-0.018408826,-0.123441264,0.021246303,-0.020481946,-0.027077094,-0.17349148,0.028737817,0.0109494645,0.08814744,0.018064713,0.006490109,0.042163588,0.02201134,-0.14329116,0.07530272,-0.052919082,0.0781666,-0.072826155,0.031506084,-0.053010084,-0.05256421,-0.074182265,-0.03493712,0.056559216,0.0074909977,-0.015151141,-0.0012995157,-0.037404962,-0.047958028,0.0522157,0.016905801,-0.012355171,-0.01873903,0.011218944,0.008104986,0.024659922,0.038632028,-0.045894634,0.019830775,0.006313107,-0.041673396,-0.04365686,0.035712156,-0.027943632,0.029432368,0.018668722,-0.06476808,-0.07596653,-0.03209095,0.090270706,-0.018886654,0.106179155,-0.02305657,-0.0030230633,0.004984457,-0.020190319,-0.04850226,0.084242456,0.022233285,0.020846331,0.04512402,-0.03298232,-0.0127937095,-0.007954857,-0.020201653,0.010975992,0.07109872,0.008630617,-0.021836687,0.037446216,-0.029368848,0.07934838,0.06846876,-0.0458088,0.004086829,-0.038782105,0.025415428,0.074339144,-0.002918127,-0.013786816,-0.027972339,-0.005762983,-0.055724878,0.060462,-0.04584281,0.0015965415,0.0108420495,-0.020939596,0.019602384,0.039790343,-0.010610726,0.01083902,-0.014065668,-0.05051467,-0.019193066,0.026961448,-0.020988392,-0.0024048921,0.025531447,0.020398648,0.004984018,-0.062104866,-0.08649761,2.6282507e-33,0.03934562,-0.012299409,-0.015235231,0.017376017,0.057351258,-0.06325882,-0.06770283,0.09328538,-0.059830695,-0.012818449,-0.0125473915,0.017723849,0.044612385,0.04136552,0.033216577,-0.044149015,-0.008254296,0.046372704,0.046850648,-0.0006830327,-0.064398296,0.011960478,0.011465125,-0.09798334,0.016961077,-0.03985612,-0.002232467,-0.012253211,-0.022340065,-0.0049026487,-0.060603652,-0.088377506,-0.030444492,0.06269576,0.05670749,-0.06591663,-0.00833813,-0.05490363,-0.058871876,0.0564543,0.09221174,0.046799675,-0.0070859203,0.0040853177,0.0074261655,-0.004625046,-0.027401559,0.060057715,-0.029254893,0.05917407,0.0583497,0.0015665805,0.087627254,-0.045508213,0.017446622,-0.0072424454,-0.10142539,-0.008842506,-0.0467285,0.019644603,-0.011795075,0.09133626,-0.07150895,0.070925444,-0.02886407,0.06273839,-0.1591145,-0.034458052,-0.013519361,0.041000158,0.07217064,-0.0348322,0.09176095,0.07673931,0.04458194,-0.015973227,-0.080685236,0.053283356,-0.02450804,0.05661485,-0.014747232,0.0081069665,-0.032925587,-0.005771578,-0.09351726,0.012489928,-0.012954779,-0.016982555,0.06887495,0.043192293,0.047773935,-0.059430666,0.040086128,-0.013478719,0.023626618,-2.326677e-33,0.10551355,-0.07946288,0.06944415,-0.13607994,-0.0018060623,-0.022871885,0.0288809,-0.008102738,0.040472806,-0.03347994,0.07342578,0.031921953,-0.014949421,-0.059913427,0.025788708,0.063629165,-0.00803833,0.020673206,0.01166364,-0.02430504,0.0061795404,-0.0044535245,0.0004002533,0.08822994,0.05916639,0.077920236,0.012965071,0.035777584,-0.0016488918,0.010138102,0.0007745324,-0.006158501,0.016553607,0.028332952,-0.044142168,0.037220664,-0.10990873,0.024214191,0.048363615,0.04411057,-0.0326018,0.030017305,-0.007084355,-0.017235776,0.06833136,-0.03720968,-0.010215628,-0.011495592,-0.013225748,-0.03571466,0.01108758,0.0033580938,-0.017824318,0.049628403,0.0059140166,0.07123323,0.021096727,0.061983306,0.060853433,-0.06678229,-0.008416975,-0.013489061,-0.024097629,-0.049192343,0.07120355,0.014546605,0.0107481815,0.0060759992,-0.01020469,0.07420737,0.060250644,0.029442308,0.0073267934,0.0082445275,0.0032041706,-0.009872701,-0.025873758,-0.04663189,-0.11200912,-0.008955655,-0.041565605,-0.024368627,-0.05063053,-0.040256646,-0.004374695,-0.01482855,0.03177959,0.052057162,0.002136189,0.0721853,-0.009809735,-0.029762872,-0.021618417,0.10518904,0.09750865,-5.0803386e-08,0.0451789,-0.0822551,-0.011467736,-0.02948997,0.010794556,0.038856957,0.038650203,-0.002673765,0.054269474,-0.0071757594,-0.023966357,0.10861062,0.07156819,0.019455768,0.028094986,-0.035730135,-0.015473137,-0.007075489,0.00038424507,-0.013368205,-0.028847648,-0.021975394,-0.07022976,0.0509282,-0.03639909,-0.03519517,0.009944182,0.054369837,0.055788655,-0.005448759,0.06600302,0.059981294,0.042474527,0.037019644,0.052268945,-0.04325623,0.010476175,-0.058674812,-0.08496589,0.14243144,0.0046122824,-0.0075828787,-0.079018116,-0.0023755294,0.091389105,-0.03955971,-0.02307784,0.075869404,-0.015907982,0.06521548,0.0038456195,0.022619233,-0.034189843,-0.0195898,-0.053382073,-0.08759515,-0.035205334,-0.014334999,-0.02498472,0.039750997,0.022570226,-0.009451722,0.18775009,-0.04148161 +2.3.1.200,"In the bacterium Listeria monocytogenes the enzyme takes part in a pathway for scavenging of lipoic acid. The enzyme is bound to 2-oxo-acid dehydrogenases such as the pyruvate dehydrogenase complex, where it transfers the lipoyl moiety from lipoyl-[glycine cleavage system H] to the E2 subunits of the complexes.",384,1.0,-0.108290344,-0.04524003,-0.049400635,-0.037184715,0.009469416,0.018738573,-0.10152251,0.043812595,0.011075492,-0.015760696,0.012854109,-0.09002176,-0.07588898,0.009975792,-0.005315677,-0.04963366,-0.017073123,0.0032846509,0.0006210708,-0.07845816,0.075201385,0.020175628,-0.024329836,-0.04622782,-0.05086858,0.09198901,0.05219317,0.024380162,-0.028780097,-0.043821443,0.053573918,-0.08711083,0.124497086,-0.06000661,-0.027084684,0.10026807,0.07964571,0.0062494064,0.15282871,0.045467004,0.044982545,0.02687713,-0.005841432,-0.007716775,0.047563102,-0.028940514,0.0011425095,0.061609946,0.036176052,-0.065245725,-0.038294543,-0.03436433,0.0068824696,-0.014833673,0.0017894714,0.0447196,0.080770224,0.03005643,-0.03521931,0.010431611,0.03751308,-0.097632565,0.05857948,0.048697077,-0.044890266,-0.09829653,0.08904364,-0.007815448,0.011175392,-0.015971513,-0.08349404,-0.06521024,-0.0028904567,-0.0342293,-0.01359754,0.036832083,-0.038804386,-0.053929072,0.020693865,-0.058950026,0.024472995,-0.06679469,0.00028040906,0.085111916,-0.0007951953,0.00027592378,-0.002318272,-0.07963129,0.043702018,0.08654942,-0.034553118,-0.069106705,-0.00029674717,-0.06331093,-0.04657249,0.04794396,0.034399353,-0.033181686,0.05449714,-0.055584125,-0.065933876,0.026129851,-0.0399446,-0.051296663,0.0051927883,0.033254817,-0.0060398793,0.048732698,-0.027515382,0.024623793,0.037128776,0.034765456,0.065038234,-0.013304925,0.0174976,0.030349312,0.044599596,-0.062412247,-0.04119493,0.04059312,0.027488856,-0.058710255,0.01427384,0.03800184,-0.052927844,0.016804624,-0.0313199,3.828708e-33,-0.007559978,-0.040742323,0.009680976,-0.03240013,-0.0010027507,-0.027589863,-0.07148199,0.05295175,-0.03153779,-0.005981811,0.011620818,-0.12852994,0.02313597,0.036354788,-0.046448987,0.024960017,-0.008519894,0.0629219,0.02965996,-0.013837574,0.029169343,0.012021606,0.011459017,0.0041643507,0.029633166,0.09762121,0.04944101,-0.056851093,0.057581376,-0.003244225,0.017837856,-0.08432079,-0.09129248,0.03174307,0.05670742,0.04963552,-0.064503536,-0.023647584,0.06352367,-0.038349815,-0.014351081,0.0029571182,-0.022719597,0.0025928833,-0.058160815,-0.029524984,-0.07101377,0.064235285,0.07841098,0.007034182,0.07150432,-0.086964235,0.0691244,-0.03648622,-0.030393776,0.06776663,-0.010715974,0.029589819,0.061387975,0.04055504,-0.023412742,0.07006552,-0.09142605,0.055748142,0.021681996,-0.0067010256,-0.09854349,-0.059783615,-0.005277686,0.04763631,0.034215998,-0.028684162,0.07666473,0.04418751,-0.053693093,0.0319395,-0.027595667,0.031190185,0.027976604,0.037812103,-0.0020416286,0.021150181,-0.0054665687,-0.088127576,-0.051047176,0.010085276,-0.06114194,-0.10063509,0.052813906,0.051153023,-0.01903659,-0.059040103,-0.0666678,-0.008589068,-0.038195353,-5.51462e-33,0.04660913,-0.08060755,0.026187051,-0.0887976,-0.07721187,0.095445015,-0.020482149,0.0023336818,0.0220846,0.0042093177,-0.015225861,0.03865429,-0.017320098,-0.029526738,0.013225666,0.06422256,0.040328033,0.055268824,-0.086826146,-0.08726373,0.056156915,-0.007956153,0.029746221,0.029517058,0.013607192,0.046694864,-0.07038424,0.07581633,-0.008492182,0.05343291,0.008302716,0.011088063,-0.07012302,0.0073728277,0.0010724386,0.08097142,-0.06720283,0.032267235,0.018888196,0.0067879558,-0.031324044,-0.0056277243,0.023361765,0.04181092,0.07258661,0.034465894,-0.06840418,0.017247578,-0.016746644,-0.012227027,0.0034204326,-0.0037126895,-0.041112963,0.05650602,0.0066770697,0.0792204,0.028411139,-0.043577746,0.012852227,-0.12582023,-0.021226197,-0.11451308,-0.014812008,0.088787906,0.009086203,-0.012892588,0.074345656,-0.0065118116,0.01978447,-0.049242124,0.070581324,0.029090997,0.0522216,0.012789228,-0.05593409,0.0050919317,-0.07445684,-0.035442445,-0.08714046,-0.012771798,0.029529443,-0.001797813,-0.03812073,-0.057481755,0.038340956,-0.08438706,-0.00022877322,0.116666324,-0.0020249467,0.006733999,-0.06454021,0.009911748,-0.054714613,0.036858723,0.1149354,-3.8854278e-08,0.07476341,-0.062832505,0.11286819,0.024757648,-0.030533694,-0.027674608,-0.097246364,-0.01814723,0.07814738,-0.033446845,-0.018346183,0.085961625,0.008907284,0.036119603,-0.034082603,0.049576573,-0.030225992,-0.04065767,-0.016978951,-0.06770486,-0.059321992,-0.030317279,-0.08085873,0.014155119,-0.0061827903,-0.05938443,0.032878544,0.010144747,0.0010846935,-0.050581183,0.025512364,0.06760086,-0.0068439674,0.007667046,0.0021917534,-0.040377054,0.0018807397,0.018817618,-0.0492713,0.07371201,0.0032709225,-0.0016001984,-0.07194129,0.0469922,0.034622625,0.07275336,-0.054625522,0.11175631,-0.018455032,0.0116209,-7.973912e-05,0.07620252,-0.017901594,0.043227896,-0.12424381,0.04773808,-0.0320575,-0.053224158,0.03001758,0.008113327,0.05217931,0.013969644,0.15317447,-0.03386795 +2.3.1.201,"This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.",384,1.0,-0.041454427,-0.08306447,-0.090965,-0.09913893,-0.052428547,0.024788832,-0.021487588,0.0132256625,-0.006196312,0.12115115,-0.03826668,-0.0571331,-0.040969964,-0.03828363,-0.005963337,0.07293111,-0.055781037,-0.036345072,-0.03989014,0.0054169386,0.07349043,0.051834628,0.06143233,0.010220806,0.009627656,0.02803658,0.10270992,-0.03552659,-0.027750548,-0.09733908,-0.059792057,-0.06002899,0.024072206,-0.07790543,0.08809041,0.042220887,0.011200053,0.028668325,0.019052807,0.0071769203,0.011749251,-0.053935155,-0.033030264,0.025279071,0.017419087,-0.008666362,-0.06918295,0.076240286,0.081637956,0.00858533,0.011350435,-0.029834243,-0.016267205,0.054484535,0.0057346267,0.04666623,-0.004558488,0.049961116,-0.010233126,0.0389879,-0.01288525,0.021215986,0.08449364,-0.0221547,0.08536394,-0.018194646,0.025412632,-0.08813286,0.021554807,-0.0065775,-0.03979546,-0.10527022,-0.009057594,0.022627225,0.03372395,0.023851806,0.06896298,-0.0119831925,0.054473348,-0.10306892,0.06068184,-0.025987372,0.022441424,0.18439326,-0.03798142,-0.00026464876,-0.04821827,-0.10340196,0.03472101,0.03508815,-0.043354705,-0.011217589,-0.0026591027,-0.0067051193,-0.10516924,-0.0067109196,-0.029254591,0.016796993,0.077802666,0.01874436,-0.009018424,0.036141,-0.09093501,-0.07929128,-0.073160626,-0.039022326,-0.03615424,-0.074859105,-0.003178393,0.029460138,0.054659314,0.02062507,0.0044051246,0.033034988,-0.09016728,0.034786955,0.03601539,-0.07723682,0.01114766,-0.090062775,0.013552494,-0.022614324,0.04574678,0.027592327,-0.060977183,-0.016280748,-0.008045535,-1.3858764e-33,0.016049111,-0.045173764,-0.008042043,-0.014594185,0.047500517,-0.055505022,-0.07971184,-0.06115876,-0.098087855,-0.008589359,-0.07344591,-0.11971905,0.01816739,0.09818429,-0.057204597,0.048827384,-0.017764667,-0.01274329,-0.01779307,-0.03272827,0.0013503822,0.110374205,0.019860843,0.016872302,0.08653267,0.07312624,-0.029955326,0.07248744,0.10049911,-0.021447306,0.039183836,-0.02801054,-0.07855362,-0.05633507,0.010179318,0.019274227,-0.04835652,-0.025311314,0.0021186597,0.07223835,0.014812692,-0.032417033,-0.035795514,-0.03533259,0.0077234963,0.02988419,-0.023992993,-0.0043666284,0.05271563,-0.029967062,0.039111603,-0.029491542,0.10263819,0.031583317,0.0059923176,-0.019560553,-0.07895043,-0.06173218,0.060427118,0.09696405,0.026824955,0.035166584,0.0038277558,0.037143584,-0.018615538,-0.016509425,-0.026483469,0.035014797,0.037247956,-0.039358635,0.019751597,-0.04448035,0.069617614,0.023133842,0.010198806,-0.035475954,-0.019500833,0.028262686,0.009760295,-0.05237401,0.031927973,-0.03903662,0.03509794,0.024337918,-0.04530262,0.019895585,-0.0093140155,-0.08714016,-0.04274933,-0.009101784,-0.046291996,-0.010354821,-0.06352391,0.08520448,-0.014731165,-2.4979325e-33,0.051495142,-0.063213035,0.06805836,-0.05949024,0.0008682102,0.0113233775,0.06763509,0.009843973,0.050960813,0.044905435,0.07283842,-0.029976368,-0.0063997633,-0.011755107,0.025685018,0.009336052,-0.045514688,0.053295128,-0.05345025,-0.010073378,0.018378485,0.060032737,0.006158134,0.08079851,0.02142755,-0.04082123,-0.018723786,0.1077841,-0.022502344,0.048115134,-0.024288563,0.018734345,-0.0377256,-0.031528007,-0.00017364153,0.06525846,-0.0041855974,0.013004797,-0.07054951,0.017479995,-0.10336357,0.044751775,0.0048114555,-0.05415102,0.034098696,0.048573654,-0.049178496,0.053744495,-0.07553109,-0.011592282,0.07916639,-0.016593307,0.14450152,0.036691736,0.025395846,0.09842099,-0.0011754929,0.0314029,0.07794784,0.017693723,-0.028157884,-0.09232099,0.0791786,0.0144538395,0.087430574,0.09700887,-0.024611773,-0.024634412,0.03986288,-0.008082606,0.009535782,0.05778651,0.0018944732,0.09247445,-0.033734456,-0.018257666,-0.12890102,-0.049431313,0.003628899,0.011600547,-0.027960943,0.0014997226,0.034571387,0.01566498,-0.030080361,-0.009349805,0.06179892,0.06085339,-0.017421402,0.06322902,-0.015048251,-0.023070082,-0.116606265,0.043906625,0.03877025,-3.685695e-08,0.081069276,-0.045920003,0.02581596,-0.06824003,0.008223876,-0.050297096,0.013564301,0.014706857,0.036548495,-0.070249155,-0.016109046,0.08261505,0.038989656,0.011796767,0.00027088664,0.000358923,0.02774538,0.044879712,-0.057491697,-0.029865619,-0.055359412,0.0066008326,-0.08197266,-0.048650123,0.039741915,-0.06099597,-0.0008698844,0.029627789,-0.012695166,0.008030098,-0.006014935,0.0054525076,0.024725484,-0.098049164,-0.029415565,0.010160025,-0.060286965,-0.09444065,-0.025880156,0.039925892,-0.0019618256,-0.024762552,0.0748838,-0.004841889,-0.03249919,-0.04495751,-0.053593766,0.046187844,-0.02488655,0.028177634,0.020109875,0.007267696,-0.05549173,-0.079037875,-0.090839274,-0.04842898,-0.08877624,-0.018398814,-0.011603212,-0.008265803,-0.019067653,-0.0012711175,0.14864527,-0.07471796 +2.3.1.202,Isolated from Helicobacter pylori. The enzyme is involved in the biosynthesis of pseudaminic acid.,384,1.0,-0.07482674,-0.0491305,-0.24885008,0.04160036,0.019200133,0.09903652,-0.07842083,0.06761276,0.02568908,-0.0054771667,0.08473558,-0.032380953,-0.059784014,0.031237645,0.022515086,0.050758615,-0.04889512,-0.023197275,0.035928167,-0.08095133,-0.03534073,0.07886562,0.009745486,-0.01726851,0.02789815,0.07110406,0.06515099,0.026218053,0.021810042,-0.006497069,0.066913724,-0.07540683,0.08470797,-0.06541021,0.12771046,0.03994772,-0.06859045,-0.029004276,0.07813107,0.0004174437,0.06612587,-0.008375205,-0.042362787,-0.039742254,-0.068751656,-0.010904894,-0.090417914,0.035334032,0.08394755,-0.044496175,-0.017502012,-0.0076793963,-0.049786568,-0.020354029,-0.052171063,0.010616127,0.033311058,-0.052633073,-0.030569453,0.024327323,0.021447655,0.038682494,-0.017815717,0.04628334,-0.0054318993,-0.006850184,0.02024695,-0.014251011,0.075563304,-0.074376166,-0.074707724,-0.011055715,0.051572114,0.042314153,-0.050257538,-0.01476777,0.0010359859,-0.031710703,-0.022182334,0.0056674504,0.025352255,-0.0014277204,0.012907709,0.11318906,0.0029010824,0.031608097,0.05091687,0.01869847,0.06589096,0.030303517,0.016503626,-0.0154849,0.0025095525,-0.032078486,-0.031589672,0.014474505,-0.017969213,0.00862481,0.006033723,-0.009972284,0.0058140066,-0.0050184503,0.05965528,-0.10736442,-0.07335018,0.10400515,-0.078945875,0.011885518,0.08118636,0.04691343,-0.052525546,0.020896718,-0.04048586,-0.08000538,0.01048461,0.052151345,0.04622507,-0.005158403,-0.022783048,-0.0019611956,0.018516317,-0.021479463,0.07609496,0.060753886,-0.01945204,-0.038621362,-0.09948455,3.5317011e-34,0.050724674,0.022290817,0.10782734,-0.06254202,-0.028704975,0.006220538,-0.04252756,-0.03632139,-0.020367162,-0.039027482,-0.05184825,-0.09282765,0.039330546,0.0010215425,-0.032552764,0.00785552,-0.0006457228,0.013819645,0.080781795,0.010966996,-0.02552866,0.062059276,0.022570582,-0.031219311,0.0011175289,0.008659681,-0.040335655,0.018875575,0.010573624,0.0041444465,-0.021279143,-0.038346857,-0.066802084,0.022299927,0.02008779,0.017479993,-0.09405395,-0.08150256,-0.021155434,0.06879874,0.0686679,-0.00020933706,-0.012848412,0.007348949,0.0026012245,-0.08622209,-0.05637587,0.07178066,0.022761349,0.07326061,-0.017570013,-0.035068657,0.04450603,0.039920714,-0.042179786,-0.04810338,0.02989508,-0.0034006052,0.07727106,0.016220856,0.06726195,0.08699882,-0.04895463,0.03278022,0.07098192,-0.049798004,-0.043106575,0.0077419863,-0.06930317,0.00718004,-0.07891962,-0.0044427994,0.047522802,-0.03572983,0.039535794,-0.07498891,-0.041811276,0.07890836,-0.03462979,0.024930606,-0.07850745,-0.062274728,0.00201803,-0.0035587999,-0.07058228,0.083788626,-0.04643764,0.005623871,-0.08408613,0.016740682,-0.02448182,-0.10609854,-1.46795965e-05,0.121540435,0.050477378,-3.1805196e-33,0.05362638,-0.07056023,0.0147192655,-0.03768601,-0.011683347,0.056345895,0.018697627,0.068835944,-0.046857644,0.038692903,0.030170796,0.046392113,0.102721415,-0.085761055,0.042873826,0.0715396,0.06504831,0.16155185,-0.016459327,0.029011456,0.030398881,0.04395964,0.0011811223,-0.045544155,-0.02863264,-0.0051379837,0.093966514,-0.015468722,-0.034672998,0.025068974,0.0031812806,0.03341721,-0.09739523,-0.08527358,-0.028964834,-0.026496029,-0.108022,-0.08259873,0.06597947,-0.008722891,-0.033856478,0.08712566,0.0038661438,0.026525358,0.03522857,0.047531653,-0.0314854,-0.031419583,0.030831078,-0.02069029,-0.003045489,0.05246832,-0.02080456,0.012034761,0.001264959,-0.0016105407,-0.048306253,-0.012371859,-0.0074146637,-0.085986,-0.036463913,-0.0009599873,-0.004708918,0.030927017,0.017072208,0.008602337,0.029311651,0.038534943,0.030673778,-0.06189588,0.019424576,0.05382255,-0.009050451,0.1061326,-0.013195487,-0.009999738,-0.07006668,-0.038031228,0.04847863,0.04121994,0.040904965,-0.05865375,0.009809951,-0.08041471,0.019198596,-0.07034712,0.016798077,0.039596893,0.06406606,0.019341975,0.041419216,0.033830263,-0.027879898,0.041303918,0.03745305,-2.5266457e-08,0.029266087,-0.10306017,0.03274266,-0.008156971,-0.0014133017,0.009032419,-0.01694801,-0.028107058,0.026787484,0.03110031,-0.007793576,0.018222144,-0.027352856,0.03135064,-0.010164798,0.03796188,-0.02227411,0.036756635,0.015910935,-0.015134699,-0.05820169,-0.06541922,0.05631981,-0.0022053006,0.015989985,-0.09103575,0.035265416,0.0037220232,-0.013491213,-0.06185281,-0.05188689,-0.0075437212,-0.09902972,-0.036544424,-0.00464193,0.06751277,0.07951446,-0.049865082,-0.026104886,0.042881522,0.009136296,-0.051165923,-0.0640097,0.034207314,0.0142320935,0.04349771,-0.036034614,-0.016598186,-0.09506872,-0.069699556,0.012026364,0.03711964,-0.007949599,-0.06496225,-0.056262773,0.06610467,-0.008183079,-0.08370582,-0.073800504,-0.04791647,-0.038436815,0.0060354206,0.12274477,0.044030055 +2.3.1.203,"The product, UDP-N,N'-diacetylbacillosamine, is an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [1,2] and O-linked glycosylation of certain L-serine residues in Neisseria species [3].",384,1.0,-0.03259834,-0.0649278,-0.11142092,-0.002069176,0.01645806,0.047528088,-0.040127337,0.049588315,0.040444348,-0.10899753,0.075039126,0.00032193327,-0.023140514,0.06934896,-0.08411683,-0.026642397,0.02324046,0.0077192215,-0.03997931,0.023029268,0.017269097,0.093687125,-0.01597227,-0.041659374,0.04726451,-0.07534003,0.051931366,-0.059051406,0.027335716,-0.07444456,-0.0030778854,-0.05265331,-0.021979019,-0.04232344,0.113277,0.008634143,0.03080134,-0.03444431,0.10778164,0.034959722,0.046001717,0.0009170076,0.0086764945,-0.02475125,-0.019129613,0.01504465,-0.020791361,0.1029265,0.086547375,-0.03369109,-0.043735906,-0.024285857,-0.05081175,0.028018743,0.0011882219,0.020809688,-0.08439383,-0.03200701,-0.02252396,0.07016005,0.029101616,0.06148566,0.051984526,-0.04142902,0.033502284,-0.07500837,0.079135545,-0.05227333,-0.01808027,0.07198984,-0.06806837,-0.054716334,0.030557875,0.026019761,0.024298802,0.07083931,-0.03033222,0.04058683,0.08391813,-0.0970841,0.041024953,-0.015208788,0.042087417,0.104656205,-0.04729081,-0.07283339,-0.0023175974,0.039352957,0.10419229,0.02517159,-0.02471487,-0.025722856,-0.029415965,-0.041485585,-0.096051306,-0.06232858,0.02311405,0.0563767,-0.033850808,-0.019320775,-0.06338405,0.013319024,0.008757696,-0.09783514,-0.110213526,-0.0020646716,0.03204111,0.04304403,0.04255705,-0.020747937,-0.050876398,0.09971524,0.011169407,-0.043751203,-0.075063355,-0.0493465,0.028004825,-0.111720726,-0.08915843,-0.062077902,0.031945918,-0.03472693,0.061928764,0.055354126,-0.024758985,0.073248774,-0.009024408,2.2584215e-33,0.07064013,0.0257442,0.05333509,-0.043833584,0.044866346,-0.041277733,-0.06133323,-0.05603851,-0.04693983,-0.055662047,-0.035511717,-0.07548049,0.0032366556,0.073199704,-0.010516062,0.056221884,-0.01603305,-0.008940843,0.04566023,-0.021922305,0.021936722,0.08348809,0.041719195,-0.009322863,0.058361832,0.0270599,-0.030959401,0.013156002,-0.008193689,-0.0066850437,0.016404407,-0.09234054,-0.09530897,-0.0054588174,0.08777361,-0.010090678,-0.010265445,-0.09621372,0.0344311,0.015375445,-0.0048763403,0.08870964,0.0059799356,-0.00973359,-0.037860993,0.022941992,-0.061970443,0.057645727,-0.024432624,0.028212033,0.050212856,-0.08914616,0.04979313,-0.016596999,-0.028695704,0.0047432864,-0.04541493,0.0011708818,0.030864576,0.07141205,0.044112746,0.027625572,-0.019409833,-0.06266229,0.035308138,-0.003469445,-0.016515179,0.073405445,0.08217977,-0.01796369,-0.044204514,-0.026993206,0.12028142,0.075229995,-0.035572115,-0.08043279,-0.05297666,0.005274587,0.093643025,-0.017285885,-0.012600851,-0.019911198,-0.007050137,-0.04074553,-0.011347893,0.0077874428,-0.018460112,-0.047624134,-0.027633479,0.01592113,0.03183126,0.013593372,-0.017115807,-0.010431759,-0.0035684833,-4.285209e-33,0.065637074,-0.077840544,0.0071242293,0.018513422,-0.04314033,-0.039659925,-0.013146219,-0.025906492,0.00053470384,-0.045973912,0.03690989,-0.01299679,0.087069705,-0.025168331,0.032456506,-0.0014083708,-0.012465289,0.114059,-0.013854218,-0.06385463,0.026414014,-0.018851107,-0.030292492,-0.012915556,0.043277346,0.009948258,-0.015563535,0.10312302,-0.031862546,0.041599497,0.0890389,0.079569615,-0.063272595,-0.14080477,-0.011381227,0.02842211,0.016057307,-0.054605972,0.021753125,-0.094838455,0.030510768,0.06989202,-0.0014475681,0.024454836,0.040811446,0.065593764,-0.069750585,-0.05185302,-0.017391805,-0.049859922,0.013529664,-0.028092578,0.0013257441,0.01425817,-0.069831945,0.099606894,0.048760757,0.053917896,0.043072786,0.0017298113,-0.029615149,-0.030261772,-0.030662635,-0.031107021,0.04201833,0.030950457,-0.009340289,0.013724096,0.10797977,-0.05086828,-0.020141343,0.004954874,0.038767286,0.059335794,-0.07034545,-0.0080358405,-0.04227924,-0.01488701,0.039068893,-0.0016813626,-0.053642184,-0.060456846,-0.051068768,-0.023370722,-0.0006846044,-0.02590555,0.050497074,0.14245546,0.002851085,0.039650545,-0.028139532,-0.0947429,-0.03616486,0.071332514,0.043474544,-4.0730182e-08,0.069652826,-0.06059462,0.03739436,-0.076538585,0.017556118,0.061235305,-0.070410244,0.025018442,0.022113139,0.012232741,0.058002833,0.022870297,-0.055391274,-0.043112215,-0.014057845,0.061247896,-0.036118418,0.025720147,-0.03418393,0.04816436,-0.06991162,0.046243712,-0.077346794,0.045583904,0.035685822,-0.07734146,0.0059226844,0.05271377,0.009814632,-0.06462281,0.011198136,0.06051566,-0.015705394,-0.04949991,-0.053579208,-0.011280337,-0.033729546,-0.027298102,0.08068428,0.031702504,-0.0016857419,0.010314408,-0.06830846,-0.007581242,0.008171227,0.075337805,-0.01538757,0.004563291,-0.12998825,0.021575594,0.02342758,-0.018565787,-0.015791811,-0.028477738,-0.10450651,0.0043939305,-0.02942359,-0.025845636,0.017097684,-0.02282859,-0.09420522,0.001940605,0.12709884,-0.018740486 +2.3.2.19,The enzyme attaches the side chain of the aminoglycoside antibiotics of the butirosin family. The side chain confers resistance against several aminoglycoside-modifying enzymes.,384,1.0,-0.07226288,-0.013744338,-0.0534947,-0.034777477,0.06150414,0.044285484,-0.1308732,0.068859406,0.07383356,-0.03135119,0.041877396,0.022069164,0.08704524,0.107274316,-0.044926573,0.002874232,-0.06730451,0.01839892,-0.0012302919,-0.036337547,0.025174707,0.03848809,0.0130229,0.0048296126,-0.03722814,0.033513512,0.019243905,0.08921353,0.023542657,-0.063503295,-0.013398689,-0.054919813,-0.045540836,0.01260189,-0.042268027,0.016753701,-0.012369183,0.021397695,0.12295895,0.026883937,-0.08785506,0.060300346,-0.049343724,-0.031032752,-0.05557997,-0.10603931,0.013059809,0.071696796,0.050453275,0.06696642,-0.017352872,0.008725294,-0.03349922,0.043181133,0.04779243,0.08260563,-0.10154968,-0.011070481,-0.07688294,-0.0009541092,0.041381914,-0.015601682,0.036510147,0.03905887,-0.093737856,-0.0238884,-0.010103064,0.011516694,-0.014720591,-0.03947799,-0.040531952,-0.0739798,0.017793952,0.06196224,0.057591673,-0.025966138,-0.006706411,0.030595923,-0.055189222,-0.09971729,-0.00015152173,-0.038081493,-0.039726645,0.13539813,0.06470908,-0.042581737,0.06716806,0.00037721597,0.03610273,-0.0273985,0.066673346,-0.08104347,0.011346094,-0.050409455,-0.008133656,-0.055539772,-0.03464809,0.06130128,-0.05523922,-0.036198184,0.022239469,-0.017958883,0.016348174,-0.0766734,-0.019288503,-0.019029975,0.020227313,-0.039206468,0.038399592,-0.040051922,-0.014156139,0.034463286,0.03848373,0.052927084,-0.046104126,-0.0066296165,0.09849502,-0.017239451,-0.09885602,0.03774534,0.03536151,-0.0067722537,-0.020602398,0.07139407,0.005680675,0.02022087,-0.07800615,1.4791706e-34,-0.0006087283,0.045545258,-0.002534733,-0.034292724,0.022166295,-0.0061824024,-0.0028443194,0.015874384,-0.08536352,-0.011302368,-0.07602595,-0.020205893,-0.018803475,0.032780103,0.0066682566,-0.036198203,0.027918134,-0.03055874,-0.010682235,0.0129455235,-0.020135997,0.034027636,-0.07092296,0.023760574,0.043702483,0.08358142,-0.017594123,0.04596435,0.05404419,-0.018095033,-0.033727475,-0.041238807,-0.101240225,-0.008638858,0.027338268,0.018868102,0.028058516,-0.02025925,0.019670835,-0.0020036297,-0.031371858,0.032599147,-0.09112816,-0.04113675,0.055904165,-0.032926273,-0.042149253,0.09772611,0.056330245,0.04046713,0.06333923,-0.12244153,0.08870024,0.0045149093,-0.008767811,0.028659243,-0.09279946,0.028235381,0.0036061606,0.08366677,0.012561516,-0.047518406,-0.0105292965,0.0564922,-0.036662262,-0.032977197,-0.037883468,-0.015285159,-0.017077997,0.07643512,-0.08836123,0.01491537,-0.005068676,0.051041283,-0.018431954,-0.014681978,-0.11213956,0.022539277,0.17201617,-0.0251429,-0.029482035,-0.03239767,0.006761713,-0.021984372,-0.04906769,-0.0024705434,0.044797216,-0.08444885,-0.027682118,0.043774813,0.05470222,-0.0813834,-0.0020369063,0.04574357,0.076040745,-2.8064417e-33,0.020571064,-0.09960513,0.085066594,-0.07504285,-0.0484883,0.11556199,0.059299566,-0.023251357,0.029503914,-0.025762193,0.06150982,-0.01708164,-0.06988743,-0.06126337,0.009845536,0.04565672,0.013410798,0.04520469,0.0074605993,-0.041294575,-0.01094885,0.02976779,0.030201819,0.02625999,-0.033698067,0.09784352,0.015149421,0.06489842,0.03536594,0.05931987,0.020441048,-0.055117298,-0.07336499,-0.10941855,-0.012768678,0.12277245,-0.04929918,0.029947057,-0.05996797,-0.0748106,0.007083015,0.023529854,-0.0035235514,0.04944175,-0.0047799423,0.033185177,-0.04417739,-0.055525694,0.004406006,-0.14572385,0.022380572,0.007830996,0.075659536,0.051084876,0.011796017,-0.0030188889,0.025774647,-0.024292013,0.021582672,-0.0034721491,-0.06980223,-0.016473595,-0.044013392,0.005999797,-0.042676497,-0.021751197,-0.009056742,-0.043325294,0.07630075,-0.024982195,0.018256921,-0.022249885,0.015748408,-0.008593759,-0.061622098,0.06721892,-0.08086481,-0.11229101,-0.0010512987,-0.012264121,-0.049687322,-0.021681622,-0.06310389,0.009258655,-0.0779405,-0.0849937,0.03851728,0.08020573,0.06859565,0.016777804,0.03763533,0.029836092,-0.026041226,-0.017766377,0.056187965,-2.7575444e-08,0.095424406,-0.079853855,0.07643325,-0.02694816,-0.033966918,0.034362294,-0.02197732,-0.039751597,-0.01596152,0.012393302,0.029026562,0.08107351,0.03145755,0.03497922,0.016809888,0.054807536,0.012207661,0.036799625,0.050893344,0.018152671,-0.13676971,0.017572127,-0.06150788,-0.01413575,0.055810276,-0.023353238,0.02323553,0.016192412,0.01370516,0.01488916,0.013235169,-0.021996515,-0.041829653,0.022949748,-0.04493052,0.006310949,-0.029866679,0.044916764,0.013969102,-0.001577312,0.07918408,-0.02444124,-0.04723505,0.003976508,0.06277157,0.029435864,-0.0082770195,-0.00134928,-0.051482707,-0.0062173735,-0.011882786,-0.00047403722,0.041039422,-0.03786838,-0.11449475,-0.0032895552,-0.027496107,-0.051055193,-0.017380025,-0.052449275,-0.08228312,0.012881689,0.15650958,0.009391418 +2.4.1.282,"The enzyme does not phosphorylate alpha,alpha-trehalose, kojibiose, nigerose, or maltose. In the reverse phosphorolysis reaction the enzyme is specific for L-rhamnose as acceptor and beta-D-glucose 1-phosphate as donor.",384,1.0,0.02760012,-0.03755445,-0.0925187,-0.020617666,0.06766777,0.049041305,-0.032024387,0.014807493,-0.018866746,0.04322749,-0.0062907445,0.01818637,-0.11633732,0.054439254,-0.069012,0.0053909332,-0.05526324,-0.014268421,0.017201256,-0.013133203,0.10389876,-0.033507608,-0.025309164,0.015168075,0.09905866,-0.04021757,0.062080894,-0.04900717,-0.02686202,-0.047080226,-0.032226562,-0.07290228,0.048403338,-0.015177628,-0.00760437,0.1416888,-0.013183434,-0.058095038,0.04164575,0.04074361,-0.005027756,-0.004135568,0.03555273,-0.019486492,-0.04839071,-0.028795306,-0.11902914,0.07508835,0.0017006429,-0.0034284221,-0.038732618,-0.060995296,-0.04587562,0.05959317,-0.0047803926,0.078894034,-0.07625656,0.022157177,-0.04232932,0.021285024,0.0017122867,0.009975298,-0.044077482,0.068819135,0.03831769,-0.0831606,0.03123621,-0.036729433,-0.009883826,-0.028607141,-0.0023112847,-0.046759225,0.016958885,0.020300614,0.018072573,0.044334356,-0.016330162,0.02603085,-0.040545758,0.0029400894,0.07195147,-0.04318544,0.01586781,0.0148460455,-0.01854655,-0.012834551,-0.03922005,0.05251264,0.07200958,0.0340576,0.008504528,-0.030922532,0.039428268,-0.073745444,-0.01860436,0.015457142,-0.012119495,0.007616656,0.0061065312,-0.047601324,-0.018466422,0.07754862,0.0280562,-0.06356918,-0.09456051,0.09004802,-0.05932556,0.036401078,-0.020482212,-0.0036445002,0.03156171,0.051233944,0.12649786,0.011615816,-0.05290444,0.011657318,-0.031731322,-0.10346659,-0.11883914,0.012659533,0.010981206,-0.028437002,0.029906133,0.008000152,-0.030589571,0.080241024,-0.06335501,1.8715027e-33,0.06091013,0.048711274,-0.00919153,-0.13630334,0.0031568666,0.011662739,-0.056930628,0.006239087,-0.05478264,-0.0283711,-0.034236327,-0.021785274,0.033486728,-0.01595893,-0.033385433,0.04126232,0.06247966,0.05270086,0.03829412,0.029281091,0.0070084077,0.047342546,-0.092159316,-0.0012098488,0.02828745,0.065252945,0.0022327832,0.0015619945,-0.006600892,-0.013796034,0.045855027,-0.030310178,-0.065698974,0.058754925,-0.00030727003,-0.041141357,-0.06594986,-0.041369095,-0.02962499,-0.013746334,0.053607177,0.0076609477,-0.029973822,0.016720857,0.008990675,-0.12470062,-0.030775856,-0.016203431,0.062074374,0.1191325,0.0040505175,-0.011793785,0.010780931,0.013414581,0.00089736975,-0.019734973,-0.01931921,0.038204115,0.03600676,0.016669214,0.0016390036,0.036239423,-0.041028425,-0.0436426,-0.03129665,-0.068745494,-0.0163882,-0.10199539,-0.08075753,0.034129642,-0.066226706,-0.062352538,0.05704689,0.021133529,0.042311642,-0.082248025,-0.008565647,-0.008523147,0.00055355846,-0.013674272,0.02368403,-0.008137263,0.04523173,0.008992239,-0.039317828,-0.054663483,0.020732142,-0.014084541,-0.049434677,-0.010818652,0.0102445595,-0.07753823,-0.06812223,0.07100115,0.04577268,-2.6990945e-33,0.10499655,-0.11743438,0.061488375,-0.07324051,-0.02538535,0.07729362,0.076375954,-0.020498216,0.07311566,-0.053161375,0.09000495,-0.009721699,-0.045010637,-0.0030711358,0.0640076,-0.021223241,0.06549568,0.07592756,-0.013511828,-0.051388066,-0.03528779,0.1284195,0.024946187,0.054285973,0.08165165,-0.022922093,0.023838904,0.09634676,-0.010377351,0.04474022,0.067427725,1.9246447e-05,-0.016723242,-0.015433816,-0.03754299,0.03397649,-0.041747663,0.012336926,0.027272182,0.074889034,0.058557328,0.077912815,0.04885716,0.014001745,0.02282568,0.019059177,-0.13137592,-0.0020304373,0.034791782,-0.06787491,-0.024446007,0.08349519,-0.0019575618,0.043956306,0.091350615,0.04997985,-0.03109885,0.03918113,-0.027549764,-0.05622575,-0.044320412,-0.08229563,0.032142654,0.0012887396,0.05687979,0.08559244,-0.0140407905,0.057228506,0.05114312,0.026537767,0.032869775,0.04700696,0.02383513,0.039271563,-0.00094153744,-0.06981886,-0.1252206,-0.047967482,0.026150938,-0.06616796,0.04659467,0.028354986,0.019002557,-0.008300965,0.041950956,-0.060120508,-0.026730904,0.06439933,0.0036337816,0.033631176,-0.0020473187,-0.07643211,-0.013871937,-0.011295691,0.17720626,-3.319858e-08,0.06458507,-0.04487932,0.011246539,-0.04697674,0.016879478,0.026210329,0.023253236,-0.03744984,-0.0155761745,0.0022853683,-0.04057962,0.06976723,0.00523543,0.03135034,0.065746434,-0.04239396,-0.04903666,0.07172566,-0.038349137,0.048558522,-0.022871215,-0.017646335,-0.11405365,0.02241378,0.046870578,0.031166315,0.05981338,0.034625113,-0.05257504,0.018200634,0.020706818,0.017166615,0.009356848,0.038643066,-0.06689412,-0.018699951,0.0003065787,0.022715855,-0.047921937,-0.012680369,0.021536008,-0.038357504,-0.046103753,0.051465873,-0.06632423,0.00928444,0.03823171,-0.014212739,0.000103259124,-0.024031974,0.05562349,-0.04886634,-0.06914001,-0.10953561,-0.058932196,-0.06134763,-0.002591044,-0.008119577,-0.021028316,-0.066203155,0.0846102,0.025532115,0.16771464,-0.085203074 +2.4.1.283,"Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Unlike the enzyme from the bacterium Streptomyces kanamyceticus, which can also accept UDP-D-glucose [2] (cf. EC 2.4.1.284, 2-deoxystreptamine glucosyltransferase), the enzyme from Bacillus circulans can only accept UDP-N-acetyl-alpha-D-glucosamine [1].",384,0.99999994,-0.036137123,-0.049466692,-0.08581121,-0.06645479,-0.032504097,0.003820254,-0.12007649,0.09093116,0.10043819,0.0034996883,-0.019455552,0.054450992,0.07907757,0.10172573,-0.055583328,-0.03338387,-0.02665109,0.0062706885,0.042910833,-0.0042893765,0.057292603,0.11826154,0.016311621,-0.04073799,0.06934809,-0.032471355,0.07988356,0.001382037,-0.07031214,-0.039788473,0.02050607,-0.07551761,0.0036211058,-0.023467083,0.10624133,0.09794023,-0.04652876,0.014850805,0.15152037,-0.014757794,-0.0646063,-0.01613248,-0.011188288,0.039310236,-0.04406039,-0.037214696,-0.0013406145,0.06576437,0.02835263,0.032610614,-0.04220827,0.016778147,0.0042633233,0.0485,0.101881504,0.045492742,-0.054810353,-0.05960151,-0.010056805,-0.07888085,0.008107684,-0.025423681,0.057254482,-0.044632085,-0.08773013,-0.0117133185,0.059630588,-0.09632392,0.0054052817,0.0062739416,-0.06818325,-0.030896494,0.031086646,0.015308674,0.03195664,0.00017693834,-0.055086173,-0.019738795,-0.04055884,-0.0751057,0.033828277,-0.015504803,0.043346927,0.08674374,0.045810487,0.008385339,0.07913108,0.008879397,0.02188049,0.04118299,0.021286665,-0.014166428,0.016171504,-0.05975198,-0.056160487,-0.10502655,-0.018803546,0.032462925,-0.02050579,-0.054477133,-0.023185544,0.039267372,-0.042262647,-0.06261941,-0.035520546,-0.006217975,0.04798918,0.03211094,0.0067677177,-0.06242579,-0.01410081,0.03773073,0.006322096,0.002009761,-0.0426528,0.077928916,0.09560868,-0.0716691,-0.047302637,0.016647194,-0.008107865,-0.006663879,0.046590153,0.009743945,-0.05227732,0.071370795,-0.004214332,3.361811e-33,-0.009763587,0.014876601,-0.009573209,-0.03661517,0.06242472,0.0067081214,-0.08582838,-0.02934415,0.02177726,-0.052300505,-0.1333051,-0.06983682,0.0149778975,0.093837366,-0.009518033,0.05541443,0.01582417,0.0017513147,0.015060829,0.026843699,0.042773046,0.0642021,0.006834494,0.04438267,0.010698199,0.06328022,-0.014621686,0.09232492,0.117054194,-0.011242554,-0.015535762,-0.0772636,-0.028662281,0.008654133,0.017272271,0.040419966,-0.0681723,0.013799681,0.08628222,0.05234941,-0.016756158,0.013586485,-0.07968376,-0.028480457,0.054529794,0.06909866,-0.00023438709,0.026512086,-0.074849434,0.038559943,0.09898607,-0.011738662,0.015990224,-0.05747646,-0.006616169,0.009444904,-0.032468587,0.008616115,0.01639981,0.06726385,0.029865533,-0.0020199046,0.034614995,-0.0253964,-0.0039855028,0.006344089,-0.051202193,-0.026419016,-0.030701995,-0.028557295,-0.05811533,0.015054933,0.027160814,0.064790644,-0.013818334,-0.03881251,-0.04767576,-0.031843726,0.11419569,-0.051837243,-0.015616359,0.0114761805,-0.05863719,-0.066944875,0.035140585,0.024004089,-0.067077816,-0.09436585,0.0077510793,0.049973965,-0.08008899,-0.07309151,-0.11570028,0.031320684,0.034207936,-5.7365296e-33,0.07576853,-0.06764479,0.06012871,-0.030669995,-0.04535363,0.10029953,0.021879777,-0.090219855,0.101086885,-0.061269645,0.077720426,-0.00282566,-0.062344175,-0.0062609995,0.0006459358,-0.010847854,-0.06110806,0.054907773,-0.039952658,0.009137383,0.008617687,0.051367212,-0.055723723,0.006350782,0.04400196,0.067844965,-0.037239764,0.10546406,0.060630735,0.020637428,0.043177743,0.002547018,-0.046829328,-0.04931819,-0.027950667,0.09518841,-0.05160922,0.03463099,-0.046659555,-0.009531615,-0.00026946166,0.028567554,-0.03487944,0.048016213,0.027207347,-0.008528855,-0.042518333,-0.049967542,-0.015525763,-0.0772033,0.054235958,0.047371175,0.05551362,-0.0029256674,0.011364679,0.06268546,0.04058823,0.026138712,0.05311318,-0.021815035,-0.06256641,-0.07469488,0.035200283,0.037222672,0.044888753,-0.0062290984,0.03306077,0.010890123,0.031635944,-0.019001327,-0.0106505295,-0.032518752,-6.0332717e-05,0.05367049,0.014523163,0.00014583748,-0.09693156,-0.05008275,0.0061653755,-0.021939782,-0.04972151,-0.025470244,-0.009744768,-0.027179739,-0.0014741166,-0.031473927,0.10772518,-0.018769762,0.014299651,-0.005724303,0.0108152935,0.025213506,0.0026626035,-0.036957007,0.06506823,-4.8546784e-08,0.102718085,0.006031907,0.022771645,-0.010022193,0.028942911,-0.06668151,-0.06018298,-0.03960017,-0.019389449,-0.0402872,-0.030271221,0.12148626,-0.020829314,-0.011223499,-0.027302634,0.01464801,-0.06452036,-0.005100316,0.0333761,0.010876813,-0.14151259,0.003456833,-0.12572879,0.007991582,0.05116044,-0.06080116,0.03024544,-0.032860417,0.026273336,-0.005923913,0.032889076,-0.0150236925,-0.014774115,-0.08205466,-0.058593426,-0.05383506,-0.08483455,-0.006855782,0.057320677,0.013066236,0.06222919,-0.017360704,-0.02228179,0.005238697,-0.029360125,0.04561728,-0.010980104,-0.02786659,-0.09652741,0.04659388,0.025994042,-0.0041946946,-0.016072955,-0.013930087,-0.061569754,0.04651281,-0.060710452,-0.05583466,-0.05434868,-0.048301075,-0.09121953,-0.020158969,0.1411185,-0.06807035 +2.4.1.284,"Involved in the biosynthesis of kanamycin B and kanamycin C. Also catalyses EC 2.4.1.283, 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase, but activity is only one fifth of that with UDP-alpha-D-glucose.",384,1.0,-0.023398839,-0.050108116,-0.039569635,-0.013671821,0.038300708,0.036501586,-0.049786624,0.009611283,0.086388655,0.042394567,0.026035713,0.0045689982,0.0063740015,-0.07421548,-0.02141629,0.029453853,-0.039416477,0.011473987,-0.02465125,-0.012448771,0.07878518,-0.00038105113,0.041288283,-0.029925812,0.0663106,0.0067846416,0.058368947,-0.0012693334,-0.078224406,-0.09982655,0.007583075,-0.07037059,0.025343273,0.005917024,0.110325165,0.099018104,-0.04615623,-0.022716153,0.109097205,-0.022006303,-0.029163837,-0.061221533,0.012502434,0.011399183,-0.012266677,-0.0027561863,-0.044372,0.0042271144,-0.028537083,-0.002147302,0.01183327,0.033065896,0.018053146,0.0032918642,0.05796315,0.02703625,-0.06485633,0.011493816,0.03081082,-0.0208206,0.06493358,0.029926972,0.039412282,-0.05850022,-0.056680635,-0.04286416,0.06233695,-0.085486695,0.04830173,-0.038329653,-0.049539607,-0.030243138,-0.022218937,-0.014648659,0.036676127,-0.018329442,-0.081289634,-0.06796782,0.00038095785,-0.051348507,0.06048652,0.014898591,0.065446354,0.07833795,-0.0014665806,0.006755302,0.045732733,-0.026446966,0.040778033,0.05403966,-0.020686138,-0.071310446,0.03148319,-0.00021907294,-0.06884121,-0.06017204,0.06453578,0.047816895,0.027994081,-0.023736598,-0.016412454,0.08767027,-0.06365793,-0.10069439,-0.043148383,-0.02523973,0.09269279,0.051996984,0.02358369,-0.06265189,0.014516564,-0.049618386,0.0026095316,0.044238374,-0.07306237,0.10095035,0.07158346,-0.06548848,-0.0380598,0.006805413,0.05013283,-0.03475899,0.058440924,0.036230598,-0.11325025,0.04944588,-0.03702996,2.4485602e-33,0.017406028,0.036933966,-0.012124949,0.039282065,0.03549934,-0.012041364,-0.10215098,-0.078767054,-0.00822052,-0.03651302,-0.15802997,-0.018645735,0.018883342,0.068820454,-0.031058794,-0.008196079,-0.015200661,-0.012428878,0.02675325,0.017810244,0.05949014,0.076293536,-0.010842459,0.005895461,0.0015575942,0.039556507,-0.035000414,0.05142407,0.13412923,0.008110318,-0.029076109,-0.05033496,0.0061951745,-0.00880793,0.04886413,0.01949238,-0.04988055,0.034400966,0.046547562,0.03472387,-0.028980024,0.0361063,-0.03448959,-0.070226885,0.01441743,0.034460206,0.020714058,0.061717153,0.03206337,0.036274113,0.06613829,-0.01769427,0.08004738,-0.019811777,-0.0025706994,-0.025372522,-0.04913913,-0.06826608,0.044927105,0.11490554,0.016820941,0.0233687,0.035753164,-0.07997212,0.018435473,-0.010086109,-0.04579539,-0.010397069,-0.039091047,-0.024520373,-0.016672598,-0.053584557,0.11708172,0.0315214,0.054805964,0.010122872,-0.03556411,0.0090837395,0.006682019,-0.025784958,-0.04846728,0.019691868,-0.016066292,-0.08313446,0.012456011,0.027229473,-0.113035396,-0.09845711,0.006343209,0.12702245,-0.078360975,-0.014106913,-0.08637817,0.024885021,0.032489672,-3.951108e-33,0.029475722,-0.042790238,0.008740439,-0.06980156,-0.03917454,0.10224217,0.031162156,-0.109000854,0.08787454,0.024521044,0.069563225,0.0012475508,-0.033582024,-0.005546961,0.057338975,-0.051371343,-0.023777034,0.09274498,-0.022270933,0.018330833,0.010997419,0.06778272,-0.106151216,0.049282417,0.08174052,0.08395771,-0.026356084,0.10447741,0.06324089,0.01660293,-0.0020682542,-0.019700294,-0.046412796,0.046085812,-0.02275996,0.07039434,-0.050563183,0.05352829,-0.05941361,0.009339409,-0.037456516,0.010889374,-0.009514532,0.027554648,0.06719446,-0.011397594,-0.034120396,0.002505198,-0.02039804,-0.07731297,0.043674603,-0.0029752632,-0.046867494,-0.033897337,0.038909204,0.10745073,0.011977126,0.05087248,0.053791016,-0.037588608,-0.04671267,-0.053049788,0.059001297,7.366746e-05,0.013267682,0.025691489,0.015536696,0.016286366,0.027685948,-0.002893052,0.012177011,0.01190557,-0.0030961514,0.03370834,0.008328882,-0.052400872,-0.11050824,-0.09003933,0.016642813,-0.07463059,-0.051782712,6.9027046e-05,0.021330636,-0.09497028,-0.06599371,-0.017792702,0.08981235,0.042284973,-0.012180124,0.039866254,0.008174682,0.010709551,-0.039687816,0.044036563,0.06590955,-3.853404e-08,0.09610062,0.006664561,0.025462285,-0.003125711,-0.024131272,-0.0099507645,-0.013415157,0.04810964,0.012692761,-0.0636818,0.0038078674,0.14497273,0.034905173,-0.042523883,-0.0064060874,0.0017277168,-0.018545518,0.03758722,-0.014767431,0.00057590846,-0.04882156,-0.00705898,-0.115558386,0.0060700616,-0.021514095,-0.13443375,0.02650101,-0.009013903,0.0055722585,-0.08416835,0.057570584,-0.01277233,-0.03015847,-0.08989819,-0.01639773,-0.025442507,-0.08605175,-0.035352603,0.032119155,0.042749397,-0.0100295795,-0.07133065,-0.0341488,0.04617106,-0.03989665,0.029135823,-0.03012785,-0.05896794,-0.06915526,0.07473777,0.020207947,-0.017191077,-0.018849522,-0.041573536,-0.0943717,0.016766958,-0.07087585,-0.011627235,-0.028948138,-0.06439718,-0.06011775,0.05642038,0.12704286,-0.051050674 +2.4.1.285,"Involved in biosynthesis of the aminoglycoside antibiotic neomycin. Requires a divalent metal ion, optimally Mg2+, Mn2+ or Co2+.",384,1.0,0.010028115,-0.033472218,-0.07254516,-0.036698923,-0.0006269948,-0.019300569,-0.014536286,0.051881462,0.05117994,-0.008366843,-0.023131436,-0.021168787,0.18651344,0.047506634,-0.011553364,-0.02061899,-0.022963312,0.026130168,-0.01135675,0.0332152,0.08571522,0.063816085,0.041050795,-0.022691427,0.012477233,-0.015335298,0.029050985,-0.0023434209,-0.017228851,0.050113197,0.06920415,-0.003485952,0.009275041,-0.06731639,0.09471403,0.04525484,-0.07486794,0.038261242,0.10323951,0.040026892,-0.061372157,0.009609345,0.068523355,-0.032611992,-0.016244093,-0.067008756,-0.009472471,-0.032284547,0.008269399,0.07454408,-0.060499206,-0.020974597,-0.05168974,0.0756518,0.10027227,0.05746778,-0.060333744,-0.081187926,-0.0102407,-0.052570365,0.040871177,-0.054457203,-0.0061997087,0.003241786,-0.07148925,-0.038740378,0.037664372,-0.06829822,0.02948493,0.014966187,-0.04368654,-0.027340112,-0.027987434,-0.012480478,-0.01869825,-0.04255113,0.10695399,-0.07940761,-0.007011029,-0.049372602,0.015153703,0.045756146,0.082350336,0.07021625,0.053796638,0.04883305,0.1422597,0.03713839,0.025407197,0.07744854,0.072037555,0.015732683,0.02726336,-0.048859853,-0.0320838,-0.05403614,-0.008339009,0.018693542,0.011404189,-0.01904158,0.037787758,0.007013847,-0.035892848,-0.011901461,0.030308412,-0.015820688,0.04332953,0.115855135,-0.07303536,0.049268324,0.052865416,-0.022252286,-0.040071525,-0.016541336,-0.032975927,0.13626908,0.15797563,-0.06273944,-0.08835052,0.0022767964,0.025597926,0.05673254,-0.030557357,0.020004077,-0.035163783,0.055633232,-0.017903365,1.4441366e-33,-0.03999402,0.0740779,-0.008620001,-0.031403966,0.027076183,0.015758945,-0.07242268,-0.110975124,0.08202254,-0.044482592,-0.101604514,-0.04225195,0.008218956,0.077624775,-0.046950515,-0.057673987,-0.010523867,-0.02542545,0.04218488,0.007587001,0.0013391046,0.04176018,0.029699374,0.03544393,0.022047367,0.085888684,-0.023633812,0.031912494,0.034890156,-0.027677264,-0.023215322,-0.05077045,-0.0273789,-0.0042410083,0.08964929,-0.02941051,-0.01702389,-0.036970016,0.08525269,0.02696095,-0.054709613,0.07146425,-0.06355592,0.032116257,0.07962679,-0.03636475,-0.05794296,0.08374052,-0.013610442,0.008905566,0.048849624,0.027317716,0.015939577,-0.011906789,-0.08322752,-0.029238088,-0.017384531,0.03007403,0.019023988,0.055740006,0.007367687,-0.0147982,0.09510908,0.06994677,0.09684993,-0.02022253,-0.018984884,-0.027580366,-0.01413442,-0.00747459,-0.08660363,-0.03822689,0.09386513,0.03028152,0.030498547,-0.022788106,-0.027689926,-0.06884218,0.035752416,0.01764993,-0.033545606,0.014521917,-0.053985,-0.030072939,-0.02978384,-0.010948002,-0.027401224,-0.06827182,0.041532144,0.03654966,-0.05345389,-0.055670362,-0.102368854,0.02245422,-0.031118864,-4.5244256e-33,0.04985053,0.0060784626,0.089003175,-0.025793673,-0.070064396,0.04649073,-0.036179107,-0.084643506,0.03165585,0.01295718,0.056246985,0.01583814,-0.056890085,-0.038397435,-0.020351313,-0.020828374,-0.002053054,0.08730832,-0.006750118,-0.011097074,0.019061899,0.03112916,-0.08643711,0.031657767,0.028760184,0.05939329,-0.055415858,0.031559177,0.026904732,0.08121968,0.01251447,-0.029501291,-0.06251868,-0.11824619,-0.0026107111,0.12989387,0.002850009,0.01590179,0.008648831,0.024598533,-0.01206439,-0.026575923,0.018932577,0.10000715,-0.025430648,-0.037053622,-0.037965257,-0.010093169,0.015874457,-0.075274765,-0.009125467,-0.010361805,0.01710732,-0.028063055,0.0050721383,-0.058182254,0.0069879917,0.003379982,0.05694383,-0.015670957,-0.025425456,-0.0037154935,-0.0041240985,-0.06411938,-0.018191218,0.033488583,-0.027699962,5.248122e-05,0.08392267,0.0138190165,0.00968901,0.07744134,0.025769757,-0.0201956,-0.001837616,0.06504783,-0.057131752,-0.08246389,0.00079763716,0.027299464,-0.0023242824,0.08302952,0.0140523,-0.02524608,-0.053369757,-0.047479615,0.051991213,0.03210148,-0.054411944,-0.06302441,-0.007881886,-0.057165746,-0.026698029,0.025112977,-0.054552708,-3.0958553e-08,0.03522359,-0.023053441,0.061305273,-0.07230122,-0.0134908315,0.031532258,-0.06332083,-0.11011414,0.04185457,-0.016325297,0.023790296,0.08176444,0.0005491793,-0.0056305397,-0.059128676,0.017647648,-0.0870289,0.026153559,-0.031065082,-0.06936247,-0.07979123,-0.032739,-0.12090895,-0.023925334,0.05920927,-0.046936348,-0.040595233,-0.0046435487,-0.07672955,0.0022349388,0.088332996,4.0442224e-05,-0.054601062,-0.024673242,-0.059846964,-0.014163598,-0.055669773,-0.016462194,0.065697476,-0.07921807,0.004864973,-0.045753036,-0.03256697,0.035956543,-0.0667763,0.01896572,-0.082431644,0.0075250803,-0.06595243,0.00940486,0.042675875,-0.0480317,-0.016982254,-0.03352708,-0.09300075,0.00994501,-0.008433681,-0.018997738,-0.006475658,-0.060529083,-0.117903076,-0.021993095,0.096928425,-0.07179328 +2.4.1.286,"Isolated from the plant Antirrhinum majus (snapdragon). Involved in the biosynthesis of aurones, plant flavonoids that provide yellow color to the flowers.",384,1.0,-0.08502158,0.030705292,-0.12082216,0.045744706,0.084097035,0.066072665,-0.010234443,-0.019740807,0.043858487,-0.040466886,0.07816835,-0.039043367,-0.019072289,-0.07480944,-0.057084084,0.046518218,-0.044196825,0.0012056247,-0.064595915,0.009958309,0.022170018,0.015225045,0.028739907,0.027185285,0.02434678,-0.018291947,0.031951766,-0.0005908072,0.047288157,-0.064910084,0.029869432,0.029368104,0.0941265,-0.048136488,-0.015111762,0.0006406487,-0.03842231,0.034319,0.093383916,0.014666948,0.040776487,-0.0055558984,0.07182287,-0.06459512,-0.00086314115,0.010438456,-0.04925777,0.04009059,0.035430305,-0.001925822,-0.06317424,-0.028656682,-0.09181882,0.053945538,-0.03615272,0.0020854538,0.0037906223,-0.029047733,0.013876355,0.013022774,0.08443769,0.054084864,0.05710584,0.0062315986,-0.09166329,-0.0025495624,-0.10472725,0.059716616,0.14662619,-0.046522506,0.06165673,-0.023529684,0.036803976,0.043586478,-0.013814721,-0.0072717043,-0.030540422,0.0036844276,-0.04603131,0.00084306236,-0.008810661,-0.015996205,0.07716623,0.08868696,0.06257138,0.05466129,-0.007177687,0.07522382,-0.02939975,-0.025514176,0.06063934,0.036453355,0.030214163,0.0029944545,-0.009948497,0.036865573,0.07224194,-0.074963145,-0.057302367,0.006326779,0.10070884,-0.029140765,0.009824981,-0.08999298,-0.05695314,0.028993813,-0.04647074,-0.09066574,0.0018377677,-0.03357379,-0.022179883,-0.033727262,-0.055931523,-0.10008126,-0.068277515,0.016466286,0.017321965,-0.024666222,-0.029539859,-0.011273932,0.0014488861,0.03389321,0.052706573,0.086318895,0.03414808,0.038919214,-0.09196389,1.0135905e-33,-0.004783345,-0.04265151,0.00026217217,-0.050476443,-0.00048780782,-0.050310526,-0.0047559747,-0.11666805,-0.043667935,-0.04803597,-0.12113047,-0.03585662,-0.059508156,-0.035626173,0.0022624717,-0.01945621,-0.033178613,-0.103478506,0.03487143,7.155669e-05,0.003971297,0.06660952,-0.052211124,0.0064891134,-0.023244366,0.007279864,0.033623926,-0.00036737524,0.057300556,0.0055858362,0.052582007,-0.031219613,0.0021439036,0.0025026966,-0.03015753,-0.018611593,-0.112521015,-0.11086732,-0.07650928,0.093062505,0.017536988,0.0019784847,0.04258533,-0.01470695,0.03430823,-0.023035983,-0.03470805,0.07295969,0.11775214,0.013835168,0.003690493,-0.012760925,0.08803453,0.016130218,-0.08558094,-0.06332339,0.0046080267,0.016275411,0.02424705,0.05751694,-0.03860891,-0.05358713,0.006703728,-0.0034229278,-0.020500606,0.068624035,-0.094838776,0.0021448296,-0.022564247,-0.0126374755,-0.015277358,-0.07882929,0.00994414,-0.039923802,0.023892535,-0.02020197,0.019958219,-0.011730909,-0.028213179,0.040273786,-0.012988338,-0.0014528751,0.008939636,0.03200548,-0.037878618,0.004588605,-0.060911655,0.023465347,0.013942939,0.038316816,0.020129712,0.023266885,-0.08086649,0.06484432,-0.039640494,-2.25722e-33,0.03902157,0.016434658,0.015411943,-0.00021561008,-0.033001937,0.10615834,-0.05287122,-0.013628197,0.03933628,0.014800399,-0.032719012,0.035694867,0.027373428,-0.05912805,0.023017842,0.062377736,0.1495648,0.19011766,-0.04693129,-0.028826974,-0.11130937,0.01685412,-0.008004325,-0.057421353,-0.016598785,0.04808682,0.057923056,-0.04657032,-0.014866171,0.02632776,0.039068658,-0.024040379,-0.10353045,-0.009967875,-0.03168454,-0.009610086,-0.058552478,-0.045722205,-0.0075144134,0.07178005,-0.013251609,0.013057849,0.048053905,0.072318465,0.052938037,0.011835657,-0.042669397,0.08973362,-0.08629175,-0.035120923,0.038099695,0.0039673345,0.101952784,0.03443979,0.07076657,-0.053901177,-0.0253943,0.05285753,0.008298379,-0.004982644,0.013610736,-0.051992808,-0.020207282,-0.04126823,0.06119625,0.08090764,-0.044214077,0.07341425,-0.038599946,-0.010806164,0.08386844,0.0377634,-0.0010529063,0.036129378,0.011501763,0.051573496,-0.043090373,-0.071244314,-0.0076029724,0.0119644655,0.0015073086,-0.0027758293,0.051316667,-0.082193166,-0.07725116,-0.02272774,-0.02216132,0.068331905,0.12811759,-0.026896628,-0.0138129275,0.07238612,-0.06421336,0.00062813744,0.13093176,-2.612085e-08,0.05446291,-0.0814305,0.026600434,-0.050620824,-0.033555545,-0.021103192,-0.033469193,0.022672268,-0.009042694,0.047206055,0.008527418,-0.002311812,0.0045134285,-0.021120455,-0.020504203,0.008161645,0.097449966,0.10741328,0.012191608,0.013678986,-0.08706894,0.021685425,-0.040262077,-0.026309254,-0.08018013,-0.041398205,0.028748775,-0.029491846,0.035037495,-0.021807885,0.041685354,0.0342897,-0.029240036,-0.048254263,-0.07666099,0.07696813,-0.0075062052,-0.017990485,-0.013701904,-0.04936273,-0.03462958,0.023024268,0.022302099,-0.008482035,-0.037985027,-0.020582007,0.021968978,0.018586548,-0.028901136,-0.02417769,0.009414882,0.010516824,0.014339123,-0.032371126,-0.11845501,-0.053146325,-0.0053883893,-0.008766724,0.03331144,-0.07741214,-0.06747671,0.004021434,0.1001018,0.112711184 +2.4.1.287,"Isolated from the bacteria Mycobacterium tuberculosis and M. smegmatis, the enzyme has dual beta-(1->4) and beta-(1->5) transferase action. Involved in the formation of the cell wall in mycobacteria.",384,1.0,-0.041255392,-0.06672749,-0.08603111,-0.009702671,0.053481314,0.05985913,-0.023449069,0.08740598,-0.003619792,0.020918135,-0.017811008,-0.018191181,0.08582495,0.07750186,-0.04452686,0.067078024,-0.03651908,-0.008645981,0.0023577884,-0.024935689,-0.035098974,0.050849084,-0.017655795,-0.08377488,0.10381971,-0.008960789,-0.01552793,0.01612978,-0.024707396,-0.095313355,-0.03644476,-0.06345643,0.028114514,-0.030250374,0.12060177,0.0016644462,-0.07309931,-0.038129043,0.09735224,-0.021016901,0.050113253,-0.051738895,0.022903116,-0.031061804,-0.008894887,0.05919445,-0.041739617,0.05478704,0.060291354,-0.007972257,-0.072268404,-0.08285915,-0.045711774,0.118831776,0.01896184,0.0068142074,-0.045144953,-0.03606029,0.07570251,0.024041899,0.026275964,0.00035888885,0.054677073,0.03451243,0.0013898365,-0.016079204,-0.06968244,0.028711623,0.01079486,-0.02922751,-0.03264739,-0.02029172,-0.0610131,0.050565958,0.057017006,-0.07338456,-0.035815224,0.015931305,-0.0141089065,0.08088534,-0.08633613,-0.045701645,-0.03553486,-0.046046227,-0.0063372897,0.010256098,0.05002847,0.051759377,0.028269699,0.05090282,0.02577099,0.005097659,-0.03813181,-0.053499997,-0.03697524,-0.08615463,0.01935002,0.04765249,0.046925385,-0.010434672,0.030859448,-0.024347523,0.08060332,-0.045813516,-0.044389363,0.0003556179,-0.010512609,-0.007513264,0.027374184,-0.03177847,-0.030126879,0.0077075018,0.028894305,0.003864366,0.042692196,-0.017361198,0.09130545,-0.03737264,-0.046659533,0.005728928,0.018971905,-0.0575086,0.06608824,0.015077221,-0.08106997,0.08166406,-0.09935217,-2.1177455e-33,0.024070738,-0.033179156,0.023437483,0.004676487,0.028253136,-0.025512602,-0.05549492,-0.019509071,-0.03898067,-0.021812681,-0.08665255,-0.057883162,0.036280308,0.082943715,-0.08330443,0.044519216,0.03959741,-0.054261487,0.11026255,0.046949178,0.017507365,0.061733603,-0.016507197,0.035824973,0.03569925,0.014372508,0.0035503684,0.013340181,0.055849675,0.013826399,0.018711604,-0.052913498,-0.07931225,-0.032763578,0.029587228,0.043252848,-0.08337886,-0.019071274,0.042405277,-0.00037703416,0.04141685,-0.011227743,0.0013585412,-0.05203524,0.0943709,0.014633293,-0.049583532,-0.019639418,-0.016058674,-0.01429897,0.0115105035,-0.045609355,0.003813581,-0.07818186,0.006344303,0.021171726,-0.027846403,0.06589644,0.028186152,0.057068545,-0.02172192,0.07618586,-0.044541746,0.07974775,-0.03360438,-0.0130948275,-0.09031446,0.019367231,-0.01767257,0.0063269436,-0.03956235,0.020147411,-0.007405112,-0.06386663,0.09033582,-0.0644044,-0.045013804,-0.053264827,0.023052126,-0.093616396,-0.015205488,0.042602144,-0.04785152,-0.022953391,-0.06403297,-0.011749991,-0.024558138,-0.034953196,-0.040488552,0.017673288,0.03917836,-0.04624897,-0.10633485,0.11311773,-0.021645544,-9.436488e-34,0.09368052,-0.11660508,0.0880927,-0.06141716,-0.041777823,0.032871906,0.05301027,0.026730752,0.029892173,0.07890851,0.039331753,0.058789104,-0.028482098,-0.038259022,0.013623327,-0.02428098,0.087278455,0.020921899,-0.055692356,-0.016812295,-0.05884176,0.06689538,0.054699216,-0.054996926,-0.03511238,0.038377736,-0.040542416,0.08727234,0.08779834,0.06403867,-0.049820337,0.05233435,0.022008259,-0.065894336,-0.10883829,-0.055441573,-0.039083466,-0.051940575,0.08865224,-0.012489028,0.023232728,0.09477701,-0.0192879,0.053939704,0.033009004,0.07826788,-0.00493164,0.013677742,-0.048464254,-0.056106962,-0.0252009,-0.033771437,0.0021947941,-0.062110357,0.032511856,0.009862051,0.048004087,0.05192064,0.0006474943,-0.07407531,-0.03612267,-0.049319804,-0.0073078712,-0.025496006,0.077852756,0.12710245,0.03120612,0.05501658,0.022492833,-0.04083146,0.010274434,0.02864532,-0.0409455,0.0018016743,0.041204344,-0.0064010373,-0.09043214,0.019420048,0.022418486,0.03189019,-0.11767198,-0.013924134,-0.014278165,-0.09174781,0.03718081,-0.10007338,0.008542663,0.08559812,0.034635507,0.007612294,-0.044171505,0.09338158,-0.061578702,0.0100656655,0.044423964,-3.2696196e-08,0.0417265,-0.07224824,0.057426523,-0.00787776,-0.023945048,-0.0009669646,-0.012627722,0.00923413,0.1166876,0.052217856,-0.032884587,0.031712294,-0.0019139232,-0.054959882,0.016318845,0.04779477,-0.051773664,-0.08894994,0.0018127629,-0.046237797,-0.019073103,-0.000407086,0.030704675,0.10428985,-0.021587038,-0.084691994,-0.0076861763,0.0141085945,-0.05651935,-0.030879887,-0.0034495909,0.059354223,-0.035093643,-0.10335166,-0.11247229,0.015942914,0.038314708,-0.04567415,0.0967971,0.046341717,0.0689044,-0.07814225,-0.039977923,-0.0017767554,-0.053588696,0.037264656,0.013456009,-0.020730315,-0.015347068,-0.0955906,0.03408296,-0.0042129727,-0.05232344,0.028831558,-0.052005168,0.06413987,-0.021927126,-0.037168875,0.008946267,-0.051698428,0.018206306,0.028454406,0.09791686,-0.0055422666 +2.4.1.288,Isolated from Mycobacterium tuberculosis. The enzyme adds approximately twenty-eight galactofuranosyl residues with alternating 1->5 and 1->6 links forming a galactan domain with approximately thirty galactofuranosyl residues. Involved in the formation of the cell wall in mycobacteria.,384,1.0,0.0019234045,-0.068834774,-0.10191107,-0.030947203,0.0155900465,0.010067743,0.016896307,0.13514672,-0.010748667,-0.015517138,-0.013463485,-0.02845864,0.11384136,0.07166147,-0.05581253,0.015596506,-0.00636183,-0.041158665,0.036496416,0.040667217,0.06131301,0.08972145,0.011952049,-0.03561572,0.10782151,-0.015768029,0.07323173,-0.012733126,-0.009340915,-0.0965255,0.038662493,-0.060258146,0.03790089,-0.055131923,0.09360373,0.029573029,-0.031009277,-0.0487898,0.17246269,-0.0053855334,0.0134311225,-0.02741138,0.046322636,-0.037763402,0.021736141,0.073612206,-0.022349833,0.09232006,0.07074835,0.01992246,-0.014177946,-0.05146339,-0.0622016,0.04559524,0.04480547,0.02066449,-0.03180682,-0.03495369,0.035096083,0.02086676,0.08790427,0.0077873254,0.061432138,0.040129654,-0.0090229465,-0.020724598,-0.03388402,-0.006165606,0.015110029,0.0021967476,-0.04624551,-0.006912748,-0.041167784,0.063011445,0.020220112,0.0071916208,-0.01986198,-0.022321133,0.014982953,0.044620935,-0.043234974,-0.037672017,0.011264358,0.0032135758,-0.028164772,-0.04596754,0.14112909,0.0683983,0.02566926,0.037909284,0.050846823,-0.029176759,0.03448552,-0.07458068,-0.04892353,-0.03936393,0.09434493,0.01480872,0.041992158,-0.018696338,0.0141012855,-0.08506798,0.089376256,-0.019135952,-0.060815737,0.05710694,-0.044362534,-0.0018553414,0.07905362,-0.03020722,-0.02698721,0.008825713,-0.013273366,-0.06692046,-0.017118756,0.003570314,0.10540048,-0.06732285,-0.08426963,0.012493617,0.036447223,-0.039767668,0.05431393,-0.013975715,-0.071999855,0.0824465,-0.035199016,3.577129e-33,0.03361867,-0.023129955,0.010563492,-0.050069533,0.072227836,-0.002283924,-0.049916223,-0.05161537,-0.043224216,-0.021583682,-0.10719258,-0.02587503,0.029458461,0.035573635,-0.099558465,0.102059774,0.029004674,-0.030496143,0.0665769,0.047848277,-0.035060007,0.0425822,-0.014420599,0.025464324,0.01797264,0.04513399,-0.0016225835,-0.0019509553,0.055760726,0.0070016226,0.017172582,-0.073511705,-0.09412106,-0.010879973,0.054022916,0.015926538,-0.045193564,-0.06399408,0.08002481,-0.02691105,0.07408566,-0.026032899,0.016088022,-0.011911304,0.062162578,0.023448177,-0.022210358,0.011315195,-0.041245714,0.0048438767,0.0294376,-0.045861486,-0.02404566,-0.024365637,0.03913743,-0.0015438246,-0.074762516,0.07570809,0.06750875,0.039121367,0.07663487,0.06493252,-0.053021844,0.115819156,-0.0007354719,-0.027503882,-0.04826751,0.033851054,0.021250185,-0.024317041,-0.023395984,-0.035465267,0.007423213,-0.03202463,0.039372604,-0.014687406,-0.04153729,-0.06388903,0.019686706,-0.05302147,0.0133421,0.066388324,-0.03774733,-0.05961298,-0.01619559,-0.005329954,-0.0477527,-0.043549217,-0.08308429,-0.026741834,-0.00463026,-0.048340276,-0.0515448,0.059082817,-0.06264296,-5.191923e-33,0.12645416,-0.11050217,0.108884715,-0.070671946,-0.009347363,0.025539309,0.08019374,0.00041955922,0.02491423,0.017256416,0.02069851,0.0054648835,-0.016520925,-0.051369686,0.01834708,0.0072343843,0.054033365,0.06900158,-0.10864274,-0.028456897,-0.038376834,0.032479364,0.012809933,-0.042700633,-0.078746475,0.020924099,-0.057054874,0.013607223,0.034407463,0.106026016,-0.043224495,0.023695108,-0.0001667352,-0.12183173,-0.083626114,-0.07148923,-0.07890402,-0.06910942,0.079870336,-0.0913272,0.0029180602,0.10182308,-0.04115166,-0.012632519,0.05156081,0.04281145,-0.059433106,-0.013818645,-0.009684331,-0.043541223,-0.04358958,-0.06752117,0.029659705,-0.034356613,-0.01989859,0.00088434695,0.04912014,0.048203815,0.08144796,-0.046701748,-0.04041348,-0.008556103,0.0071623176,-0.0524789,0.044249844,0.104229815,-0.0053764917,0.049666688,0.04773224,-0.09112568,0.02968076,-0.015789758,-0.014158905,0.053857327,0.048407253,0.04856986,-0.07929522,-0.02310477,0.004632183,0.013679034,0.01743335,0.004809597,-0.008832451,-0.09040949,0.05926698,-0.07075565,0.013273994,0.084219284,-0.018056842,0.01089183,-0.021939615,0.075625345,-0.0753777,0.0037410469,0.0966024,-3.6593523e-08,0.02461909,-0.007593425,0.074741475,-0.054905202,0.018086754,0.009513104,-0.037182987,-0.015821256,0.076633334,-0.0233689,0.034259535,0.02193223,-0.04978098,0.00833565,0.0013717654,0.034994207,-0.03656691,-0.045819134,-0.011529205,-0.036941703,-0.06282239,0.020895878,0.0032580588,0.01399522,-0.01065719,-0.038211733,-0.015091414,0.048958812,-0.037339475,-0.0036229708,0.022613034,0.04546714,-0.06881542,-0.07565323,-0.13750628,0.0019794023,-0.029520305,-0.011074941,0.07336723,0.016830467,0.043220073,-0.08583601,0.00847823,-0.016062459,-0.081238516,0.021151446,-0.02989032,0.028887425,-0.05850566,-0.028179033,0.009038339,-0.042173866,-0.086109675,-0.030998223,-0.020402603,0.014225068,0.006537231,-0.028186366,-0.05018303,-0.0717544,-0.013604069,-0.013866815,0.090113886,-0.010110831 +2.4.2.45,Requires Mg2+. Isolated from Mycobacterium tuberculosis. Has some activity with other polyprenyl phosphates.,384,1.0,-0.07681106,-0.07815646,0.015407094,-0.009863521,0.012891716,-0.03930726,0.038289323,0.07392966,-0.06319428,-8.303477e-05,-0.018736595,0.051449094,0.11575713,0.06499243,-0.0063128415,0.0042267963,0.08284978,0.03593424,0.037422355,0.034918543,0.06804363,0.060517933,0.021479338,-0.04263176,0.027346535,0.072676286,0.061039705,-0.0049342373,0.04349972,-0.015998745,-0.021837708,0.017320303,0.0144860195,-0.13368496,0.07191842,0.10297736,-0.06090833,0.0073966086,0.040448762,-0.017824905,0.067356706,-0.05446464,0.07350282,-0.008494813,0.010438424,-0.036158442,0.017812809,-0.0162863,0.068993606,0.048356093,-0.06778712,-0.012737682,-0.05984156,0.0105370255,0.041414708,-0.044534527,-0.12129801,0.029760752,0.01096472,-0.009853248,-0.011678691,0.015731907,-0.000540017,0.040161114,0.049921118,0.06878914,-0.01610998,-0.022536917,0.053538855,0.0009100397,-0.044652097,0.005054758,-0.022003332,0.07285328,-0.08544227,-0.00612613,0.038244583,-0.10377571,0.058805645,0.06107492,-0.07373088,-0.00902634,0.07286833,0.06185999,0.055800144,0.016896753,0.1023246,0.07494438,-0.027687818,0.07624052,0.04561556,0.030281665,0.048227817,0.02721205,-0.0048694583,0.012987081,-0.043839,-0.007818312,-0.037689075,0.009822714,-0.023113878,0.021038074,0.034523893,0.0005867413,-0.045199957,-0.02618732,-0.08459368,-0.037569247,0.052246943,0.027262801,0.019354984,-0.006682704,-0.015848773,-0.026612889,-0.020638155,0.03577172,0.04362377,-0.07211716,-0.032751814,-0.019828072,0.030608146,-0.07952569,-0.00016540068,-0.029138358,-0.05269145,0.013407858,-0.030953418,2.1082653e-33,-0.018836886,-0.045754783,0.11604795,0.015772257,-0.01770849,0.058771197,-0.047035325,-0.052081916,-0.031015344,-0.06139389,-0.06753716,-0.049324792,-0.029995376,0.056254573,-0.056473464,-0.018555053,-0.00090978487,0.013240049,0.15383133,0.011877041,0.025230292,0.06377835,0.00666404,0.02970678,-0.016778119,0.08718877,0.01762236,-0.08314363,0.06376805,0.017088022,0.058504034,-0.07798235,-0.07306976,0.011976936,-0.022475624,-0.0209594,-0.10044863,-0.074576735,0.010185887,0.014195738,-0.012595598,0.014341599,-0.026466658,0.01010557,0.08755984,-0.08394013,-0.016062368,0.037164766,-0.034278233,0.04528871,0.051821057,0.009182191,-0.06019193,0.019908158,-0.06403101,-0.014867721,-0.028287739,0.053342965,0.07064473,0.03189371,0.048328713,0.058814414,0.02240795,0.063496664,0.06842439,-0.034251884,-0.08908616,-0.038731094,-0.0014531899,-0.00013755533,0.038762305,-0.06634069,0.035382666,-0.0011826876,0.021145731,-0.021809833,-0.0350041,-0.027347881,0.05043659,0.002280817,-0.021840772,-0.075192325,0.010042151,2.6759024e-05,-0.086856164,-0.004289582,-0.039587837,-0.045041084,0.012534649,-0.004636707,0.031445347,-0.04760527,-0.12422908,0.08155288,-0.05336159,-3.415752e-33,0.07693844,-0.039955277,0.1190003,-0.0028821572,-0.048518185,-0.02271564,0.05549556,-0.11296989,0.06586277,0.03267355,0.049809396,-0.01800295,0.010707473,-0.033074215,-0.047210664,0.014693485,0.021176552,0.04760589,-0.07025003,0.0022385928,-0.011089316,0.08997851,0.044637028,0.014262752,0.02073723,0.047159255,-0.0027688981,-0.031422287,-8.26449e-05,0.11498429,-0.015886994,0.12415905,-0.077934735,-0.10762606,-0.13973707,-0.049113717,-0.044560023,-0.08456214,-0.024572227,-0.04240315,0.014242716,0.08295895,0.053437553,0.030384572,-0.009941001,0.01744523,0.046974346,0.019522144,0.042376388,-0.047514938,-0.00985572,-0.009961931,-0.06551329,-0.030297939,0.007126011,-0.02869978,-0.016519891,0.00055113,0.006987957,-0.07405936,0.016231228,-0.027711222,-0.0058628526,-0.09146912,0.047772452,0.1406915,0.054147787,0.059272718,0.04000531,-0.024461282,0.06791229,0.010900334,0.09774382,-0.009379105,0.038851332,0.06271568,-0.07224757,0.000497997,0.028551705,-0.05940085,-0.027612353,-0.0028290492,-0.06687029,-0.0071266377,0.019738663,-0.123293616,-0.00021812467,0.019851735,-0.022536468,0.016982723,-0.08534044,0.012978852,-0.07109401,0.088552475,0.035431452,-2.4995126e-08,-0.037191372,-0.055111635,0.03819438,-0.053725645,-0.005371454,0.012831604,-0.023499904,0.010512886,0.09747153,-0.025230186,0.0453776,-0.032426357,0.0083700605,-0.015574422,0.04725447,0.0016907299,-0.007776691,-0.008784179,-0.0641354,-0.12525915,-0.07727805,-0.058102213,-0.013762626,0.053257424,-0.02411937,-0.028925816,0.031316135,0.043391544,0.014682528,-0.020386718,-0.013721365,-0.0072736763,-0.028096387,-0.09184563,-0.09321532,0.07272986,0.008455079,0.006789534,0.01718772,-0.033704143,-0.057287406,-0.049492855,0.04113392,0.022972364,-0.055394415,0.004249186,-0.05243167,0.04656162,-0.066833355,-0.04637127,0.061764356,-0.049356036,-0.058075976,-0.027397774,-0.034962572,0.06845785,0.014756843,-0.052233584,-0.04091287,-0.082777016,-0.008273555,-0.015572032,0.07462311,-0.02163749 +2.4.2.46,Isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum. These arabinofuranosyl groups form the start of an arabinofuranan chain as part of the of the cell wall in mycobacteria. ,384,1.0,-0.026528846,-0.033259414,-0.07981995,-0.034908846,-0.028314168,0.019575097,-0.02841558,0.044961113,0.04680577,-0.009403106,0.054016765,-0.01776091,0.12353434,-0.053062875,-0.014814652,0.03982532,-0.02424984,0.015652725,-0.032842595,-0.06116636,-0.003345593,0.14657067,-0.0016402369,-0.03455792,-0.010331199,0.027822152,0.011694952,0.051707048,-0.00013516258,-0.06544671,0.0040867245,-0.07782834,-0.009904062,-0.0112559,0.078324966,0.060944308,-0.0317511,-0.021155804,0.19201499,0.005854582,0.04907891,-0.0022591832,0.07924939,-0.026990868,-0.020390963,0.049876984,-0.015795916,0.04217575,0.05874001,-0.003412316,0.012484361,-0.024973359,-0.07739141,0.099052995,0.079576716,-0.021980096,-0.038118687,-0.015423129,0.036449514,0.030040292,0.022569718,0.016712425,0.039437257,0.012203508,-0.08958194,0.06543905,0.014390867,0.0059527704,0.08024768,-0.021684248,0.021351358,0.004730048,-0.00034519963,0.09132843,-0.0136010675,-0.0072723823,-0.039364737,-0.03169714,-0.041676734,0.026504066,-0.029575508,-0.04037694,0.015983297,-0.009238789,-0.08540429,-0.10173488,0.10865598,0.062864624,0.021232752,0.048102282,0.0507241,0.03478509,0.0835401,-0.09390273,-0.01942959,-0.051794022,0.080213755,-0.014798915,0.0008222973,0.0074335746,0.011341182,-0.10369461,0.06256206,-0.044365063,-0.09097828,0.0077975853,-0.07587987,-0.058785874,0.036332913,-0.03073937,-0.091196574,0.034856033,-0.0657706,-0.05163863,-0.01983519,-0.050469015,0.10343005,-0.096266225,0.002270508,0.018706368,0.042874016,-0.034493856,0.100307465,-0.013426802,-0.038663864,0.057176467,-0.09397693,3.926687e-33,0.011668809,-0.067220174,0.033339772,-0.03310693,0.028789088,-0.034380846,-0.038542517,-0.014812166,-0.026304556,-0.06759866,-0.096696466,-0.058816925,-0.0029886966,0.056742255,-0.14345434,0.067461796,-0.024080554,-0.09281981,0.018324036,0.030964404,0.0140438,0.03443806,0.068993896,0.032463707,-0.037986375,0.010817726,0.0059049046,-0.046910573,0.05938268,0.0017791365,-0.022953112,-0.06587495,-0.10366084,-0.03776614,0.028429268,0.069655105,-0.10677042,-0.030703891,0.055832684,0.030448284,0.004000484,-0.021113858,0.05533992,-0.04270294,0.1070074,0.07616017,-0.05120136,-0.0037064047,-0.008773259,0.018519538,0.00876877,-0.018140217,-0.0029757975,-0.023056248,-0.0073228665,-0.05290675,-0.027241705,0.07776833,0.0055653937,0.052501902,0.06343305,0.05449506,-0.018435642,0.06532729,0.006951233,0.040595062,-0.08182982,0.046577655,-0.019971602,-0.022511259,0.03366827,-0.06961648,0.053471085,0.015062836,0.056524444,0.024306519,-0.07297784,-0.07054421,-0.05236261,-0.032559108,-0.024202313,0.0021655946,-0.00024428195,-0.0045654224,-0.15004425,0.011264879,-0.024367109,0.024951637,-0.068235256,-0.018211884,-0.015754163,-0.004709869,-0.0010743092,0.08187414,-0.038379617,-5.894447e-33,0.12639692,-0.034793254,0.10376838,-0.06865049,0.029556738,0.010608978,0.07516139,0.037466645,-0.00563922,0.10286916,0.03614842,0.011192779,0.0012530627,-0.052767705,0.024209686,0.030540006,0.06303411,0.041678596,-0.039521568,0.002320958,-0.057215944,0.023861099,-0.038235184,-0.061145257,-0.011062883,-0.0018151357,0.004968529,0.07042537,0.023563486,0.02557232,-0.014986917,0.03240898,-0.0036164743,-0.07706565,-0.107494175,0.015135895,-0.10414624,-0.08036158,0.00804234,-0.07083749,0.024196295,0.1389073,-0.029007142,0.039431576,0.017685577,0.016470538,-0.026629953,-0.0235765,-0.060098633,-0.02579693,-0.048129246,0.024074383,0.034818694,-0.079291455,0.03796031,0.028056625,0.039902095,0.049883004,0.017717475,-0.011280243,-0.06651359,-0.035499707,0.021365365,-0.060486723,0.053243786,0.058475252,-0.009406029,-0.009488025,0.0235028,0.02524859,0.041916892,0.019299714,-0.025625719,-0.016893066,0.05126413,0.08169219,-0.06167309,-0.04282851,-0.071469866,-0.008313456,0.050431337,-0.06429105,-0.029273579,-4.821255e-05,0.04229246,-0.078205004,0.031950753,0.06157513,-0.0035575351,0.034788232,-0.0020724528,0.008452927,-0.073923595,0.06461906,0.010218499,-3.2249797e-08,0.0024683215,-0.026424803,0.052855544,-0.013081385,0.032905627,0.049385834,-0.0106469095,0.09163095,0.03918365,0.009665342,0.03672865,-0.055733256,-0.02318824,0.0489058,-0.015215905,0.064282596,-0.04183779,-0.043209516,0.012285187,-0.035251796,-0.14013,-0.04217611,-0.052696537,0.039275967,-0.017506978,-0.04520137,0.009456581,0.029004723,-0.010375404,-0.0060036182,-0.0027611665,0.021434503,-0.064279,-0.1033296,-0.07254774,0.00601352,-0.061860982,0.023208039,0.032912374,0.0048033427,0.05766642,0.015592865,-0.021330807,0.029234026,-0.011271058,-0.0023741738,-0.05126823,0.02309418,-0.03926154,0.016849568,0.081432424,-0.023725739,-0.04946379,-0.005792978,-0.02180834,0.003357421,-0.026081923,-0.02741871,-0.0346472,-0.008397735,-0.05642976,-0.044236343,0.11526152,0.020975947 +2.4.2.47,Isolated from Mycobacterium smegmatis. Involved in the formation of the cell wall in mycobacteria. ,384,0.99999994,-0.04519423,-0.02295911,-0.06837318,0.017466538,0.036302652,-0.011060293,-0.02248281,0.10431095,-0.008234863,0.0148073295,0.007046342,-0.047008235,0.09613733,0.025562743,-0.02610049,0.036504675,-0.005332238,-0.0022975095,-0.029460901,0.021200176,-0.004428234,0.055460945,-0.040852696,-0.111122936,0.075590774,0.013554157,-0.050667733,0.01677181,-0.013159056,-0.04541408,0.010860141,-0.041973107,0.04877593,-0.04623338,0.19471903,-0.03903244,-0.066902205,0.010709621,0.12554353,-0.055927057,0.008013347,-0.007876837,0.035203632,-0.024930181,-0.053254686,0.07920792,-0.037740994,0.017033247,0.02355636,-0.0039661922,-0.08265237,-0.027466873,-0.051973674,0.050910737,0.009423258,-0.0040442627,-0.016737683,-0.039317623,0.04507218,-0.042256847,0.011796937,-0.01574592,0.053262025,0.027776904,-0.04301911,-0.08056928,-0.032362346,0.05169802,0.066004865,0.018843815,0.007896673,0.032984827,0.022321634,0.09105439,0.08238295,-0.027666327,-2.696808e-05,-0.04070542,0.016957587,0.08346539,-0.083901085,-0.0032603417,-0.047740724,-0.02406962,-0.049472496,-0.07159148,0.11606971,0.04607748,0.0027944753,0.05172671,0.0020278806,0.0021428743,-0.0116191935,-0.06332321,0.00068178517,-0.041700974,0.029832331,0.024176186,0.007804356,-0.029060865,0.022513263,-0.060749844,0.08279766,-0.05521526,-0.052448474,-0.040695593,-0.09609369,-0.013123634,0.028281692,0.008035154,-0.022193253,0.015720518,-0.021673806,-0.04637157,0.056243427,-0.01978585,0.15329334,-0.016436754,-0.025426093,-0.018662132,0.017834475,-0.04339643,0.06044726,-0.0091355825,-0.05597102,0.039978996,-0.039187938,-2.514504e-33,-0.0122486865,-0.09044399,0.008568563,-0.0030198589,0.052060314,-0.048387386,-0.03560109,-0.017941045,-0.023863515,-0.015890313,-0.078525275,-0.06717077,0.03822996,0.036069,-0.14501542,0.017385218,0.0007740779,-0.05387932,0.038185302,0.05854408,0.039540317,0.037670024,0.054369166,0.04646213,-0.038258888,-0.007874193,-0.002444174,-0.0290454,0.03712354,0.0033883613,0.061859395,-0.043285344,-0.04846463,-0.051980697,0.070013665,0.06861098,-0.051935524,-0.036288824,0.009795186,0.014103322,0.037615437,-0.01757293,0.026175272,-0.04492097,0.103912205,0.028478308,-0.06490429,0.010108882,-0.010900118,-0.027286578,0.013746625,-0.06867299,0.03296652,-0.06870143,-0.011686636,-0.059552163,0.00025914868,0.031417247,0.013771642,0.03559715,-0.009591291,0.1119525,-0.055911098,0.15277766,-0.027503427,-0.05780064,-0.058488462,0.07661444,-0.046471156,-0.009933764,-0.03095422,0.0044699437,-0.049543284,-0.046759017,0.074459106,-0.06300892,-0.06296545,-0.0029882537,-0.043001845,-0.04888604,0.018852457,0.04174337,-0.061518304,-0.017820343,-0.09258747,0.006543719,-0.080573365,0.026957277,-0.024991482,0.012105241,0.0007775898,-0.0659321,-0.08124996,0.09115065,-0.056399543,-2.0506798e-33,0.08035644,-0.062250316,0.11212343,-0.015900347,0.0008201599,0.05861585,0.0327471,0.10077709,0.009453735,0.06422053,0.013265882,0.03891642,-0.022925055,-0.01672801,0.017149502,0.002152257,0.07512305,0.031087877,-0.05505458,0.027529992,-0.13294022,0.022652866,0.0130179,-0.095606014,0.015346643,0.02610849,-0.011222831,0.030503346,0.016794255,0.052426208,-0.015216005,0.04191257,-0.016703356,-0.09803598,-0.0514852,-0.053474978,-0.060064115,-0.10055279,0.060237844,-0.06719257,0.0009880628,0.08005407,0.0005758548,0.070882246,0.012105593,0.028626041,-0.03726479,0.014392947,-0.057950165,0.004109581,-0.057669092,-0.022651453,0.04773296,-0.08087618,0.01866949,0.027287904,0.024303058,0.048023667,0.0075855623,-0.010516191,-0.02792133,-0.03677542,0.0029045038,-0.010885644,0.07827198,0.1433903,0.0027339552,0.090906456,0.0077859024,-0.0678317,-0.012210419,0.09501789,-0.06389858,-0.009533168,0.0322544,0.0321314,-0.054140598,0.061244007,-0.006708877,0.06797955,-0.011417625,-0.08149333,0.019561218,-0.10308248,0.06592506,-0.083988145,0.006368153,0.03937154,-0.0046644574,-0.01048761,-0.038511794,0.054176953,-0.048780706,0.023728624,-0.0074268966,-2.3774723e-08,0.01383089,-0.10134326,0.015309635,-0.018168887,-0.013605403,0.01866956,-0.036475495,-0.024272125,0.08281408,0.05777914,0.010750769,-0.027016673,-0.011090311,-0.040194537,0.018108042,0.026428012,-0.070389405,-0.0914201,0.03678981,0.013449886,-0.061597086,-0.044003155,0.028211087,0.10747758,0.015187793,-0.027821055,0.014985432,-0.01819792,-0.025336167,-0.04094658,0.022258475,0.019481383,-0.046554625,-0.05357616,-0.0942242,0.010505699,0.0076612444,-0.079271756,0.092764705,0.03029623,0.07373993,0.04087247,-0.040347315,-0.017533446,-0.03721728,0.0389266,-0.02915365,-0.0047926763,-0.06631061,-0.081593536,-0.029399373,0.030885288,-0.06809033,0.07046247,-0.021921823,0.03326092,0.04280124,-0.02715796,0.0026486563,-0.014888048,-0.030033356,0.04544991,0.05379372,0.07515223 +2.4.99.17,"The reaction is a combined transfer and isomerization of the ribose moiety of S-adenosyl-L-methionine to the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. It is part of the queuosine biosynthesis pathway.",384,1.0,-0.09250531,-0.04689076,-0.056471743,0.021786667,-0.028933013,0.008804256,0.060675833,0.058795415,0.059551965,0.046568427,0.0894803,-0.025662016,-0.041473545,-0.01853119,-0.08092718,0.026537158,-0.08496335,-0.020207394,0.009750449,-0.030263452,-0.011807013,0.08932547,-0.037583947,0.0102629345,0.061142653,-0.012913529,-0.0064055566,-0.012102308,0.045722753,-0.061259206,-0.007846546,-0.019975763,0.0408502,0.020836525,-0.023794739,0.073948905,-0.024041362,-0.032832716,0.083841436,-0.016308798,0.060777638,-0.040942453,0.03079733,-0.0050537027,0.046572074,0.027075173,-0.00543824,0.060704164,-0.0050312746,-0.0017645638,0.0039871293,-0.012366192,-0.0913871,-0.02634413,0.018538354,0.047300085,-0.031261604,-0.010595439,0.0008347779,-0.022819502,0.08545058,-0.0059433547,-0.0042669587,-0.028090565,0.07571317,-0.09229486,0.06762674,-0.0046607405,0.10205929,0.009058853,0.0023354257,-0.009001874,-0.032609265,-0.015786737,-0.06878773,0.023660803,-0.007309503,-0.008077936,0.022034274,0.033166755,0.028879186,-0.031359907,0.05678516,0.00035402415,0.029601315,-0.010471858,-0.03655575,-0.023195963,0.0731273,0.029617058,-0.007261653,-0.029625464,0.013503245,-0.097341456,-0.08019309,0.006266595,0.021540977,0.0430693,0.033365145,0.0373616,0.003756178,0.02026882,-0.020780897,-0.045256168,-0.08283432,0.042912763,0.027058318,-0.016053306,0.008411777,0.017471373,-0.048956603,0.024150025,0.057564184,0.0027646082,-0.034878682,0.071762964,-0.032425605,-0.030338813,0.017868448,-0.02389614,-0.0077720145,0.040189553,-0.04520822,0.051845167,-0.020582702,-0.027219936,-0.059140112,2.4295795e-33,0.062749535,0.07945113,-0.010272538,-0.037231155,0.038789615,-0.042413548,-0.08015416,-0.023728399,-0.056111198,-0.012270726,-0.109034434,-0.10482769,0.04447555,-0.017443981,-0.0799829,-0.017245812,-0.07372264,0.021511652,0.0028919647,-0.05219099,-0.058031943,0.054836992,-0.06575811,0.023523942,-0.018072221,0.011483203,-0.05917842,0.010442442,-0.0032654568,-0.043552488,-0.007167024,0.04525129,-0.080120735,0.021900358,0.080694824,-0.071741626,-0.04942503,-0.030101998,0.02245978,0.016848369,0.029413123,0.036428135,-0.050696474,0.0031236478,0.003192449,0.0025340577,-0.0139142405,0.04808546,0.06955133,-0.006177236,0.04687,-0.08767522,0.0030829848,0.009779316,0.036050487,-0.016109372,-0.0262997,-0.10118715,0.045862462,0.09697039,0.049474113,-0.039560005,0.014143421,-0.014969347,-0.024808642,0.02458549,-0.08617994,-0.042868763,0.040547103,0.036502335,0.021779027,-0.08039644,0.09130056,0.026560852,-0.004952051,-0.013853451,-0.06454121,0.003005409,-0.056732945,0.028834624,-0.035986435,-0.02730537,-0.04159814,-0.038318235,-0.08259322,0.054397933,0.047729947,-0.11405433,0.045024924,0.10309374,0.016312242,-0.06683288,-0.058759216,-0.042577032,0.049095526,-2.2057454e-33,0.017819172,-0.0755117,-0.014765908,-0.03572681,-0.113974914,0.038166963,0.019256124,-0.09536478,0.04468418,-0.029546015,0.07788944,0.018909516,-0.01032916,-0.06437611,0.0043392316,-0.058195468,0.11716512,0.053541075,-0.0359365,-0.027634881,0.0423914,0.003997201,-0.036793835,-0.025005301,0.042696457,-0.00655898,0.0138053,0.038918417,0.024046978,0.1362351,-0.07385271,-0.10018903,-0.031151453,0.03290108,-0.00592819,0.04397669,0.014359434,0.05023586,-0.026064884,-0.07283361,0.065415025,0.03132238,0.036667313,0.15019502,0.043451305,0.06439765,-0.08288398,-0.06678642,-0.076815695,-0.069330804,0.11616328,0.01915794,0.022004038,-0.0030389181,-0.011089802,0.07929578,-0.012537948,-0.0654952,-0.023477212,-0.038513537,0.014542082,-0.09232969,-0.012284198,-0.105115585,0.07940565,0.036106635,-0.03460623,0.086323075,0.051459465,-0.019927084,-0.02934255,-0.004100854,0.08002116,0.059032813,0.008317972,-0.08090994,-0.045659874,-0.06617766,0.0032498671,-0.08103876,-0.09782395,-0.003643167,0.009593568,-0.025660854,-0.014445576,-0.0024284052,-0.0029950745,0.14510043,0.045165475,0.060241487,-0.0016881557,0.014799581,0.052054964,0.06547796,0.032762095,-3.5962252e-08,-0.015197382,-0.053554237,-0.0009911607,-0.0014372094,-0.0011834909,0.12799144,0.01790471,0.031428095,0.031079028,-0.0049570217,-0.037186768,0.1305864,0.041236088,-0.015576741,0.06353391,0.0332258,-0.06583367,0.03584899,-0.04185327,-0.11681535,-0.038190067,0.056988634,-0.083826184,0.00980819,-0.024358006,0.020055238,0.03143712,0.13239492,0.011796042,-0.061755974,0.07236774,-0.011094517,0.009069417,-0.0062107327,0.013677138,0.009659074,0.007787529,-0.0044191545,0.027175266,0.012978074,-0.034639645,0.08751923,-0.0767842,0.08935754,-0.04025447,0.0651173,-0.0046340153,0.02423695,-0.021308502,0.08570428,0.10224581,0.04716209,0.011552007,0.025067603,-0.10399842,-0.06723637,0.018704643,-0.007718719,-0.04982881,0.015013939,-0.009103534,-0.023295732,0.07968547,-0.028377645 +2.6.1.93,"The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin and ribostamycin. Works in combination with EC 1.1.3.43, paromamine 6-oxidase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces kanamyceticus can also catalyse EC 2.6.1.94, 2'-deamino-2'-hydroxyneamine transaminase, which leads to production of kanamycin A [3]. The enzyme from the bacterium Streptomyces fradiae can also catalyse EC 2.6.1.95, leading to production of neomycin C [2].",384,0.99999994,-0.012648008,-0.047803685,-0.08777518,-0.052886218,0.011513325,0.03041465,-0.10147754,0.07964814,0.083990656,0.017158788,-0.020733343,-0.011363323,0.088836074,0.015181342,-0.019281685,0.01735014,-0.062050823,0.009573758,0.015978461,-0.0036249356,0.053641044,0.0076305936,0.034573518,-0.0032965548,0.05122687,0.010531645,0.04042992,0.015471487,-0.08953928,-0.09383114,0.07163106,-0.06283408,0.042871565,-0.032776184,0.05302527,0.09312031,-0.06687038,-0.05307955,0.12745818,0.029218039,-0.0879605,-0.022308746,-0.023188971,-0.004596341,0.012818724,-0.026781911,0.053108416,0.051979896,0.014850049,0.012024962,-0.0068660905,-0.02322183,-0.009930734,0.007434386,0.055952158,0.06496489,-0.07873894,-0.016264489,-0.0065094596,-0.039391417,0.07315964,-0.0027261053,0.027622063,-0.057281505,-0.13230646,-0.051449046,0.016275503,-0.06832813,0.07541675,-0.020148067,-0.07292136,-0.05042701,0.03309547,0.038523756,0.020836927,-0.0029699593,-0.00044396834,-0.053199586,-0.050545733,-0.0482755,-0.014713459,-0.029567897,0.014597102,0.09649423,0.052274197,0.014135478,0.09426308,-0.0105647305,0.056891236,0.09096819,0.08638678,-0.014683027,0.05437875,-0.04112017,-0.043687783,-0.05855536,0.0096156355,0.045166347,0.090470575,-0.03048809,-0.004309321,0.031673998,-0.06981768,-0.08918946,0.033503544,0.0047147437,0.03467759,0.09992939,0.028089019,-0.066080056,-0.011967813,-0.04324908,-0.015328797,-0.0008057996,-0.015247865,0.14824124,0.13527972,-0.0830504,-0.07775296,0.015956126,0.022508191,0.037690062,0.033707447,0.0604373,-0.047528833,0.054002233,-0.08283503,3.2719298e-33,-0.023126276,0.08049085,0.0071666166,-0.023381885,0.019255927,0.03132075,-0.10507484,-0.015864557,0.0060263244,-0.0672894,-0.109293245,-0.028455712,0.037877277,0.02297389,-0.0005222588,-0.049356163,-0.0063364147,0.02027825,-0.021523003,0.0037266868,0.03964823,0.017319022,-0.016768776,0.007433637,0.019647988,0.04744375,0.024467187,0.021332545,0.12698747,-0.016416922,-0.057323333,-0.036500383,-0.0386361,-0.021953702,-0.00410873,-0.004270353,-0.05943226,0.012070261,0.05918631,0.08528213,-0.03916365,0.04133841,-0.07699492,-0.03922924,0.062372398,-0.066049546,-0.014929048,0.11049815,0.046359934,-0.028018063,0.03605587,-0.052441232,0.09952386,-0.037256476,-0.028159868,-0.017131256,-0.037469022,0.022761429,0.084224395,0.06978364,0.051513594,0.025220443,0.042654056,-0.019015832,0.00496098,0.0011567123,-0.005219904,-0.0013572372,-0.056973107,0.003984509,-0.09512219,0.022851001,0.052572235,0.0131807355,0.025846196,-0.01160184,-0.10640936,0.0039998447,0.050246503,0.017958341,-0.046272255,-0.02216721,-0.034635898,-0.03588096,0.052078716,0.051121842,-0.03742003,-0.083273835,-0.0073748045,0.12913133,-0.019444706,-0.11004684,-0.09910436,0.008041405,0.03317512,-3.784195e-33,0.06955597,-0.072496116,-0.0034094555,-0.0394345,-0.002525535,0.07472356,0.00048401696,-0.0611612,0.03764828,-0.041514363,0.049018975,-0.028356982,-0.018396052,-0.05135829,-0.03922192,-0.062060483,0.01721079,0.075891495,-0.039890442,0.03901777,-0.0035440116,0.020374935,-0.048086233,0.003183142,0.047400765,0.076913804,-0.034257438,0.066678114,0.038201205,0.0792492,-0.021918058,-0.034919586,-0.02926621,-0.029654302,-0.004485685,0.11732984,-0.09094898,0.01719252,0.03798764,-0.03993906,0.013391717,-0.033404816,-0.0077346493,0.078912765,0.035944186,0.032294884,-0.0566873,0.016363556,0.008828923,-0.06006704,0.03416845,-0.004605137,0.020692063,0.011393788,0.012221435,-0.019694295,-0.0029779465,0.014883851,0.027559612,0.009382095,-0.048781507,-0.047347803,0.05478278,-0.012130113,0.024255322,0.033845074,-0.045975678,0.07982003,0.04831889,-0.04459955,0.034725897,0.029591875,0.0024298881,0.02549412,0.03490047,0.0065295105,-0.05530139,-0.0556489,0.009528503,-0.03060635,-0.029428318,0.003519724,0.036664292,-0.06794541,-0.00040024112,0.01718358,0.09269538,0.05507334,-0.038384557,0.008104971,0.013620474,-0.013146681,-0.016433056,0.026986409,0.064757384,-4.5268127e-08,0.06440081,-0.057454273,0.06006963,-0.040108517,0.026673038,0.012146671,-0.04409844,-0.032322306,-0.011687409,-0.08806793,-0.012345255,0.09156822,0.0688354,-0.03478619,-0.025173414,0.004009296,-0.04764756,0.03148958,0.013160778,-0.033784438,-0.102835424,-0.02132629,-0.11516811,0.031634584,0.082698986,-0.0392931,-0.03068177,-0.024170088,-0.009813951,-0.06312402,0.07246632,-0.02930564,-0.037924066,0.0055658943,-0.0066605764,-0.0030193508,-0.09433369,-0.006534973,0.029385185,-0.029823044,0.046101794,-0.028712368,-0.10357677,0.023551365,-0.03014469,0.027792132,-0.015904667,-0.034558218,-0.06981312,-0.010052826,0.07150874,-0.0007693025,0.028919673,-0.006981466,-0.0973449,0.04646943,-0.04520356,-0.0852892,-0.05283897,-0.07347794,-0.021817526,-0.026986983,0.17070055,-0.03987408 +2.6.1.94,"The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of kanamycin A and kanamycin D. The enzyme, characterized from the bacterium Streptomyces kanamyceticus, can also catalyse EC 2.6.1.93, neamine transaminase.",384,1.0,0.017715657,-0.034220617,-0.061965358,-0.012674782,0.020427084,0.048168417,-0.086139895,0.050066505,0.07571904,0.06299763,0.057339597,-0.008749689,0.046207935,0.015986511,-0.028682046,-0.0027927945,-0.0770233,0.00056182744,0.016900182,-0.024091797,0.10639595,0.046968833,0.042567316,-0.06624666,0.03544432,-0.01325333,0.04517585,-0.022250352,-0.025359059,-0.07412566,0.04311479,-0.028831307,-0.024564572,-0.046668854,0.056603696,0.07542693,-0.0721293,-0.08169913,0.12108495,0.010277645,-0.02937822,-0.075541526,-0.025303604,-0.05344089,0.019129723,0.02639714,0.037687358,-0.013375004,0.024948481,-0.017750444,-0.0010561218,-0.037313435,0.03409614,-0.0068707922,0.06225604,0.07778507,-0.043074455,0.01286302,0.0012779081,-0.043031435,0.08956136,0.014670581,0.015997624,-0.052489948,-0.062121887,-0.049907092,0.053574104,-0.046346534,0.088737264,-0.016032757,-0.030685943,-0.064034484,0.02012453,-0.02031913,0.027310338,0.008091997,-0.045486506,-0.022430101,-0.030522767,-0.033811018,0.006468681,-0.0519294,0.0069513144,0.054249726,0.03076691,0.015684977,0.071529604,-0.013844447,0.050078563,0.093226396,0.00037823152,-0.035145722,0.013525553,-0.07321572,-0.0866522,-0.083490305,-1.2256603e-05,0.06647354,0.05887725,-0.038059097,-0.014653176,0.09605512,-0.097916216,-0.06414359,-0.008311453,-0.019831615,0.051411714,0.08970904,0.009314545,-0.060868554,0.019171918,-0.05067347,0.042101633,0.009848898,-0.002482304,0.13297597,0.096741505,-0.064163156,-0.070452206,0.014546829,0.056352016,-0.020604962,0.008665007,0.055480357,-0.06834862,0.041695703,-0.06645633,1.2365466e-33,0.0015953798,0.07002455,-0.0049243052,-0.031318802,0.022961855,-0.008828477,-0.15052144,-0.0037696988,-0.025428066,-0.09195175,-0.08647602,-0.034280684,0.034698263,0.04724988,-0.021521606,-0.020698778,-0.031365987,0.029650994,0.013100943,0.006305489,0.02996611,0.038694866,7.138313e-05,-0.0078812195,-0.026994245,-0.0068311077,-0.0063918545,-0.024595946,0.0704056,-0.024452822,-0.011364026,-0.06600005,-0.028163882,-0.009156348,0.037711307,0.03551882,-0.02042087,0.05650509,0.02653913,0.06741211,-0.026098343,0.027270066,-0.011730178,-0.04318128,0.045288976,-0.020994125,0.024147267,0.07546532,0.08403963,0.019779932,0.067911565,-0.018847078,0.12434486,-0.017894387,-0.03651427,0.0055411556,-0.044731744,-0.033362884,0.031108454,0.09285223,0.008281346,-0.013449214,-0.012680625,-0.030785138,0.017815704,0.033019546,-0.04177102,-0.047190573,-0.022105176,-0.021656277,-0.083807535,-0.0023723086,0.079278976,0.053707365,-0.012372444,0.021014903,-0.11729581,-0.003438093,0.0038053058,-0.0068049,-0.06968762,0.01462555,-0.061437283,-0.051563565,0.03757025,0.033785015,-0.05829125,-0.095099755,0.019021478,0.07887421,-0.017511928,-0.059123244,-0.084086366,0.006163927,0.06410347,-2.085602e-33,0.06626023,-0.050247017,-0.034402523,-0.05291711,-0.008876866,0.09858044,0.044453327,-0.031566758,0.030632999,-0.033994313,0.07419885,-0.016442433,-0.0016146518,-0.015861325,-0.0020591116,-0.07538917,0.022337895,0.12269988,0.025396455,0.024412319,-0.0045166877,0.050901745,-0.054712515,0.012159569,0.08893027,0.11697326,-0.00634712,0.09789155,0.014809424,0.038164675,0.0039337697,-0.035987634,-0.041796163,0.034728494,0.002429128,0.13005792,-0.050050367,0.047012936,0.05435391,-0.021428343,0.043733213,0.023215717,0.011631268,0.063540764,0.038927134,-0.021261586,-0.08632525,0.046302382,-0.004182383,-0.09514404,0.030760553,0.027641233,0.012478886,-0.031846374,0.046652343,0.05096113,-0.00047902978,0.028807724,0.05217931,0.015091102,-0.039357033,-0.0245783,0.06422423,-0.03272125,0.0016993475,-0.008013024,-0.0070750113,0.080994226,0.014241546,-0.061566364,0.022556085,0.08176367,-0.000658582,0.026215233,-0.005303529,-0.09630208,-0.09861388,-0.06517374,0.005404323,-0.06742583,-0.056514252,-0.011365708,0.021525435,-0.08904369,-0.028081233,0.04516731,0.037367392,0.020829378,0.01533372,-0.04527526,-0.018873636,-0.016515,-0.053085577,0.044942867,0.09518043,-3.4900562e-08,0.07057203,-0.07715528,0.06407961,-0.02286855,0.0314379,0.033603173,0.0017906156,-0.0153585635,-0.021412324,-0.08633744,-0.0016517713,0.08332497,0.052015018,-0.03333624,-0.01710969,0.0510915,-0.051687066,0.035312098,-0.044810783,-0.05550817,-0.0723921,-0.035493746,-0.12445294,0.050969504,0.03534949,-0.052730218,-0.016572505,0.0008020646,-0.01482285,-0.10208174,0.043598115,-0.02416431,-0.058944803,-0.012771771,-0.02347413,-0.022320012,-0.052417725,-0.0070654606,0.02202177,-0.012189904,-0.017160727,-0.0026424895,-0.09662475,0.031348366,-0.015380998,0.03466621,0.013049917,-0.039399467,-0.0633285,0.03085342,0.078032084,-0.012773073,0.03926926,0.006908953,-0.120987386,0.009092859,-0.055105947,-0.049300827,-0.044875186,-0.026674662,0.002690808,0.042338006,0.20350316,-0.07191177 +2.6.1.95,"The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase, to replace the 6'''-hydroxy group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group. +The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC 2.6.1.93, neamine transaminase.",384,0.99999994,-0.02882027,-0.04021804,-0.08741724,-0.04768832,-0.0054102456,0.013042378,-0.0723975,0.0838192,0.063799076,-0.00044487338,0.0053416695,0.0010771208,0.101042815,0.049181186,-0.039194815,0.0136491,-0.061841834,-0.0060820035,0.0025194322,-0.027188439,0.06257742,0.053575914,0.04266051,-0.033416897,0.049277615,-0.015505247,0.017682184,0.04566964,-0.023823755,-0.060439922,0.088544585,-0.011939722,-0.021285668,-0.02803509,0.042819366,0.07168642,-0.09517448,-0.07722105,0.113123894,0.019793965,-0.04068549,-0.037120145,-0.031169603,-0.019854616,0.023131035,-0.040000092,-0.007858152,0.054464635,0.068891585,-0.0029989674,-0.012454299,-0.07274167,-0.028701013,0.07446947,0.07340137,0.091043636,-0.037416674,-0.050774544,-0.022604322,-0.01243813,0.0800071,0.012082078,-0.0049854233,-0.009438998,-0.07609837,-0.051114354,0.036824517,-0.068895936,0.053051043,-0.029058967,-0.11328389,-0.09918549,0.031259637,0.020572854,-0.014765217,-0.029698966,-0.009376746,-0.028015152,-0.04818337,-0.0407983,0.0006342199,-0.034555055,-0.0033466648,0.09446321,0.05918596,-0.006494498,0.06821955,0.002582908,0.068163864,0.07143756,0.0056743557,-0.0074183675,0.008086821,-0.08912937,-0.08781533,-0.06667121,-0.008580029,0.090748444,0.053600393,-0.024142144,0.0021149805,0.07522769,-0.09303967,-0.037498858,0.043362573,0.0016197246,0.027616289,0.13999392,-0.007259714,-0.03256896,-0.030280791,-0.05754845,0.005531099,-0.013671359,-0.04229585,0.14539993,0.11266085,-0.047010574,-0.112587854,-0.040861465,0.04606914,0.046304837,0.023482962,0.009997062,-0.034836814,0.051265784,-0.07009971,1.3392735e-33,-0.0030860256,0.07199125,0.0026347488,-0.039234344,0.020092335,0.036617786,-0.13790923,0.015404616,0.03569912,-0.04970961,-0.089960426,-0.032984626,0.054269355,0.06573732,-0.028003009,-0.058981013,-0.0027588906,0.009915374,-0.020050323,-0.0019640138,0.043416727,0.01914141,-0.006776503,-0.020256158,-0.011468325,0.0371695,-0.041538708,0.05321114,0.08713231,-0.035364594,-0.05405375,-0.02592233,-0.08242122,-0.02649476,0.019484434,-0.005154019,-0.029885376,-0.030550739,0.078762166,0.059985537,-0.03565189,0.04971361,0.0011351088,-0.04149508,0.07606894,-0.021061571,-0.020914368,0.102473855,0.08178768,-0.0011907307,0.052340813,-0.04969765,0.084910624,-0.028775144,-0.019489292,0.008935724,-0.014556311,0.026912494,0.0478821,0.08978886,0.041284118,0.0020647573,-0.006527169,0.0074642403,0.029587196,0.030071452,-0.021354422,-0.014901046,-0.049541183,0.02089914,-0.11483384,0.06696611,0.071968466,0.03855841,0.010689435,-0.019466357,-0.0834521,-0.02586234,0.02249241,0.0038488402,-0.024956152,-0.012273525,-0.050964512,-0.017369986,0.045588605,0.030614883,-0.01790036,-0.06491664,0.01166369,0.04460033,-0.030387247,-0.11127755,-0.1097867,-0.014448755,0.03889544,-3.241273e-33,0.08736618,-0.04442137,0.0024513307,-0.064128675,-0.0061677503,0.05099535,0.0013520613,0.0056634066,0.017251179,-0.022424847,0.05784833,0.02563524,-0.016272683,-0.048848107,-0.03950461,-0.06473838,-0.020913102,0.089593254,-0.01129535,0.035079863,0.020622399,0.049323305,-0.0468529,-0.006447323,0.06779271,0.035736166,0.007958705,0.058473803,0.021096218,0.07297011,-0.015221747,-0.052250676,-0.05437276,-0.027699467,0.03867801,0.15024666,-0.061116803,0.006125546,0.044061925,-0.05295763,0.03433054,-0.0019582133,0.0037705137,0.07937664,0.046400927,0.04461978,-0.113745145,0.03436309,-0.02894735,-0.051327914,0.04026534,0.013543292,0.015629092,0.0146333985,0.013070566,-0.037234005,0.036057387,-0.028769467,0.013634553,0.0076511833,-0.033087544,0.015502149,0.012899209,-0.05385367,0.0019540542,0.011036913,-0.05296968,0.10806354,0.0581124,0.011637417,0.048511896,0.023903502,-0.037010245,-0.0344297,0.012741275,-0.013131687,-0.062359426,-0.03747954,-0.0030098322,0.00048376137,-0.0023740542,0.012305295,0.037405167,-0.04445262,-0.018869154,0.007231,0.029020654,0.040458936,-0.008281218,-0.027892832,-0.004535784,-0.0039273836,-0.009889884,0.03422676,0.030366924,-4.1349487e-08,0.0604903,-0.055181626,0.10620669,-0.03504026,0.07132398,0.02032105,-0.055187747,-0.07276542,0.009074142,-0.060085572,-0.016808758,0.09315705,0.01848114,-0.03285756,-0.06799645,0.03315739,-0.07638463,0.05578517,-0.0003401568,-0.021272978,-0.08404627,-0.016054517,-0.110331826,0.04105567,0.08257485,-0.044248667,-0.020744856,-0.0012613161,-0.05468433,-0.04053479,0.077015825,-0.002996117,-0.039254412,0.019717842,-0.04459639,-0.02902276,-0.058452982,-0.0065094894,0.025241334,-0.03816694,0.04166238,-0.045442864,-0.1005264,0.009917626,-0.030459555,0.033423953,-0.009059313,-0.06629814,-0.035552535,0.013517194,0.09261122,-0.011159185,0.010431592,-0.023596972,-0.10419145,2.576654e-05,-0.056113347,-0.07243565,-0.018241776,-0.0368781,-0.017462207,0.0017024123,0.21810825,-0.019756794 +2.7.1.177,"The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP.",384,0.99999994,-0.05095531,-0.036093242,-0.037872687,-0.053272225,-0.060567986,0.06521429,0.0027718889,0.050940175,0.05406208,4.6203386e-05,-0.014363139,-0.041059177,-0.030081414,0.049492545,-0.023824858,-0.04268248,0.023949476,-0.016512128,0.025118753,-0.089834064,-0.017121263,0.0431247,-0.0055728843,-0.028503519,0.042902105,0.00984092,0.10463197,0.051317953,0.020548094,-0.014782024,-0.109203584,-0.019585306,0.071639456,-0.03937423,0.014418452,0.13153253,-0.04161363,-0.05211259,0.08041161,-0.01742184,0.0414861,0.033278964,-0.044538055,0.06550975,0.0073307753,0.038530823,0.015781544,0.112538196,0.011508075,-0.02517624,-0.00460274,-0.0071088946,-0.0057192566,0.0064492407,-0.013053749,0.009481149,-0.08452716,-0.07346847,-0.018474348,-0.0352005,-0.017855052,-0.040822994,0.010081162,0.010595781,0.09056543,-0.03680476,0.059473086,-0.0062695676,0.03416811,-0.07236534,-0.0343926,-0.011223653,-0.014250792,0.03844536,-0.08174987,-0.00096401543,0.020521352,-0.030401267,0.021180928,-0.016918339,0.06561208,0.03043195,0.035065345,0.07440834,0.10096214,-0.084277056,0.022089623,0.068953656,0.04954553,0.07699376,0.0014562219,-0.027697058,0.02055676,-0.056550547,-0.039894413,-0.0062996955,-0.021802647,-0.046873525,-0.033555314,-0.03881532,0.0022587974,0.08496902,0.040306587,-0.027552495,-0.00101185,-0.024736768,-0.021899695,0.08508364,0.0039685,0.0006260428,0.011194084,0.054313645,0.011989333,0.002965732,0.023969395,0.05016712,-0.0027897973,-0.1062359,-0.08689353,0.025087962,-0.064178966,-0.11402841,-0.030034054,0.06827682,-0.07587204,0.0116781145,-0.050330594,-2.8781587e-34,0.03619004,0.0024377936,0.013553636,-0.048802514,0.059470654,-0.009424551,-0.046481576,0.017469205,-0.025092322,-0.05670965,-0.06991276,-0.063005954,0.050062124,0.041902754,-0.029977513,0.006302703,-0.069201045,0.06329615,0.051965278,-0.028222678,-0.03194186,0.024323594,0.049449004,0.00048191726,-0.009989425,0.10228212,-0.07295618,0.012130511,0.026601668,-0.013342925,-0.03902892,-0.050095864,-0.11573762,0.030958677,0.0251275,-0.01876895,-0.06965986,-0.039798867,0.035773486,0.101037644,-0.054085568,0.031334635,-0.0031095606,-0.028525198,-0.011039927,-0.09948683,-0.02949111,0.018276708,-0.022998832,0.09641019,0.06935895,-0.009187284,0.025051463,-0.08628135,-0.054040942,0.006955932,0.03470551,0.042122375,-0.0116359135,0.07564603,0.07151545,0.07427453,-0.020419504,0.061670456,-0.040735073,0.046242256,-0.08243851,-0.1298946,0.07147471,0.113505475,-0.019197194,-0.038309015,0.07247052,0.025215134,0.010932252,-0.027396772,-0.03573432,-0.008703238,0.008444171,0.01925423,-0.033883832,-0.057500664,0.006083817,0.0075887186,-0.10611808,0.019112833,0.060823575,-0.016248701,-0.018351737,0.007268095,0.048859313,0.036366444,-0.041706864,0.036048334,0.051147908,-8.024324e-34,0.09645935,-0.064340815,0.027920054,-0.118325,-0.044848494,0.013700478,0.0060084355,-0.069468655,0.0716639,0.024604965,0.09001821,-0.010193794,0.00068158616,-0.006943708,-0.01070555,-0.03845858,0.054127242,0.1078916,-0.12851264,-0.04630799,0.003485899,0.0108827315,0.038181696,0.029384391,-0.003592943,0.022173416,0.014897582,0.049318932,0.03475994,0.05886339,-0.036549665,0.06093763,-0.07329961,-0.011510987,-0.015832646,0.021517925,0.01857616,0.070160374,0.017272295,0.006000622,0.06468854,0.11825081,-0.00651204,0.09239974,-0.04305455,0.095900156,0.023188971,-0.009818997,-0.024137212,-0.05226035,0.08153663,0.0071206624,0.0064864256,0.050413046,0.015810352,0.06504944,-0.028050257,-0.048971217,-0.021288954,-0.09993105,-0.06490294,-0.069604546,-0.0011170373,-0.059258904,0.068809,0.008545713,-0.009682202,0.012187186,0.024954222,0.044736527,0.00084040576,0.05401616,0.041950878,-0.043462,-0.101555,-0.0030204721,-0.03278201,-0.044648934,0.069249935,-0.088090986,-0.040187716,0.0063881483,-0.063066445,-0.05631141,-0.059278846,-0.018881353,-0.006421155,0.10826827,0.037970267,0.056439314,-0.035880893,-0.018283699,-0.035832204,0.02722547,0.05095985,-3.377998e-08,0.06480249,-0.08504013,-0.041091066,-0.0016447674,0.018922651,0.0840745,-0.06338801,0.021071613,0.11317735,-0.031868413,0.025430143,0.088557705,-0.03090223,-0.006164976,-0.029770589,0.024443863,-0.005043583,0.0183447,-0.019315302,-0.05825999,-0.07486081,-0.0051676044,-0.047816116,0.033334892,0.048433214,-0.004300607,-0.019758223,0.0076717054,-0.0009491653,-0.04330598,0.002333867,-0.022268059,-0.033079036,-0.02631743,-0.0042828005,0.021212459,-0.0060966644,-0.011734014,-0.048683546,0.012752313,0.0019139769,-0.024648532,-0.11956986,0.03366666,-0.045661677,0.05609342,-0.020576207,0.016612599,-0.05879599,-0.039146,0.05672066,-0.023942286,0.02740654,-0.033937056,-0.03813614,0.06895374,-0.0038803276,-0.14089376,-0.0838919,-0.03220307,-0.002794774,0.07875426,0.14643231,-0.085242264 +2.7.4.26,"The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as prenyl phosphate, geranyl phosphate, or fosfomycin. ",384,1.0,-0.04603068,-0.037220933,-0.06376368,-0.06502789,0.023398628,0.009289233,-0.043791045,0.013959129,0.05735436,-0.0051385122,0.0025954167,-0.036420725,-0.018405631,0.08197419,-0.09171417,0.0055543734,-0.04012217,0.037456382,0.06862275,-0.05146855,0.07689465,0.098566145,-0.0067240125,-0.041884556,-0.007421237,0.038681205,0.006909689,0.0034255392,-0.00041817635,-0.0675615,-0.0067716558,-0.023017054,0.089296356,-0.03356095,0.0067454292,0.16307682,-0.075924166,-0.01974659,0.06363007,-0.024966255,0.045747217,-0.023028133,0.06574043,0.041978877,-0.06425071,-0.0021307804,0.036733355,-0.04813358,0.059287105,-0.030425686,-0.07862626,-0.004316048,-0.028429873,0.034110025,0.045603156,0.034556292,-0.007911052,0.0010783349,0.00597967,-0.037578844,0.056115765,-0.034774706,0.046694994,0.030251706,0.02060478,-0.0050121904,-0.033399727,0.006803344,0.043474745,-0.11388479,0.025205433,-0.059305128,-0.019136675,-0.025399866,-0.015816784,0.08323678,-0.04603611,-0.03432255,-0.01326686,-0.022090826,0.030518617,0.0031988947,-0.0016657406,0.028856106,0.052409146,0.028818537,0.01621709,0.04573038,0.042547368,0.018305719,0.024972828,-0.06686717,-0.049008686,-0.07294219,-0.05116722,-0.008445152,0.010848268,-0.045405664,-0.03770619,-0.019822882,0.02421913,0.031885207,-0.0636051,-0.072780944,-0.0633897,0.024246017,-0.03483439,0.071973175,0.0037139289,0.04312553,-0.02766594,-0.008212349,0.0133209005,-0.01044801,0.035716746,0.08086699,0.039798226,-0.05857129,-0.12132875,0.027837094,-0.08413956,-0.09176553,0.008259101,-0.0040356675,-0.044823185,0.035342056,-0.1356382,1.559998e-33,0.030016456,0.012251523,-0.0008279021,-0.051611114,0.022479717,-0.02665337,-0.03263591,-0.01581935,-0.023030696,-0.14284451,-0.013598896,-0.03952296,0.038555577,-0.056812957,-0.08346149,-0.019743295,-0.04077095,0.023024544,0.071540296,-0.024946187,0.035177857,0.038946047,-0.00575203,-0.05315865,0.019851519,0.014701551,0.024626903,-0.032194108,0.066853575,-0.0065590325,0.016183713,-0.12105323,-0.101074465,-0.009073503,0.101005144,-0.017127499,-0.058934364,-0.026251115,-0.04888994,-0.0051176418,-0.06192942,0.04514054,-0.025666455,-0.016649202,0.047074743,-0.0666664,-0.026740978,0.12952179,0.036580805,0.078339495,0.06030805,-0.076216094,0.0801492,-0.08411679,-0.09246199,0.0012385135,-0.010501427,0.0031667536,0.009281607,0.038249444,0.029374747,-0.022042016,-0.054012228,0.040974114,0.049120482,0.030945841,-0.0847957,-0.055535465,0.06426485,0.15934499,-0.023861714,-0.07455873,0.009018203,0.03972279,-0.01835801,0.01228545,-0.037602868,-0.008490263,-0.012948301,0.023173397,0.01877614,-0.06659318,0.013241045,0.02475883,-0.005963273,0.014159636,-0.0023696176,-0.08541612,0.03449625,0.00796941,0.09652296,-0.0438785,-0.04775677,0.061978977,-0.024521543,-2.682844e-33,0.10152646,-0.05494877,0.10138614,-0.06802171,-0.035828754,0.08987794,0.013935686,-0.0064159404,0.040043186,-0.033678092,0.016662473,0.0029952158,0.022151412,-0.07412304,-0.025943121,-0.055830088,0.056276437,0.07165639,0.041814607,0.048370074,-0.012470819,0.06611352,0.014976462,0.018958421,5.2785963e-05,0.024459261,0.02873839,0.040853932,-0.006087651,0.051311363,0.03710369,0.06972772,-0.069189295,-0.045967873,-0.056013092,0.010558602,-0.06508056,-0.027957808,0.027195962,0.0037755952,0.07337564,0.10186963,0.0023485133,0.030033931,-0.050823197,0.037828084,-0.059796967,0.106209725,-0.016172843,-0.094911724,-0.026001634,-0.025271911,0.00084427005,0.0015419514,0.08575243,0.05984459,0.017594848,0.016891973,0.032128107,-0.047837395,-0.050269965,-0.057229124,0.0015009987,-0.03378687,0.03395685,0.07237564,0.023596155,-0.017830893,-0.05230785,0.02456818,0.063808754,-0.02263352,0.07592664,0.06122959,0.0098700095,0.0025962465,-0.041052513,-0.031273868,0.030286824,-0.051549803,-0.03167052,0.079491355,-0.06875855,-0.093916185,0.0071442877,-0.053033493,0.0069397325,0.05718886,0.0010204382,0.021688892,0.010814739,0.0662392,-0.05268955,-0.020478107,0.07557342,-3.826244e-08,0.049239125,-0.031162845,0.08057805,-0.0049042837,-0.024918117,-0.00065308507,0.04333358,0.039141826,0.10099932,0.020405741,0.035431456,0.034395244,0.05347094,-0.06009162,0.04056072,0.08169341,0.014358214,0.031009357,-0.06474791,-0.019630847,-0.038124993,-0.026955998,-0.056142442,0.038398117,0.037615735,-0.039600566,0.013040582,0.037355427,-0.025269667,-0.04388347,0.03450819,-0.007749505,0.03218067,-0.08486018,-0.090285234,0.063917994,-0.0395312,-0.00087321905,-0.045801513,0.00024347915,-0.0037580207,-0.028881302,-0.051235303,0.018709542,-0.050901778,0.07478803,-0.05769763,0.093519814,-0.06481931,0.018293263,0.03911597,-0.02207299,0.033835344,-0.09694791,-0.11509276,0.0036303136,0.03400344,-0.046609692,-0.021135427,-0.07926473,0.07490432,-5.765143e-05,0.1684934,-0.042365298 +2.7.8.35,"Isolated from Mycobacterium tuberculosis and Mycobacterium smegmatis. This enzyme catalyses the synthesis of monotrans,octacis-decaprenyl-N-acetyl-alpha-D-glucosaminyl diphosphate (mycobacterial lipid I), an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. cf. EC 2.7.8.33, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase.",384,0.99999994,-0.13367718,-0.053191707,-0.09187602,-0.06900714,-0.03473582,-0.025938287,-0.020529795,0.07429351,0.010942056,0.0119829755,-0.017386906,-0.045177393,0.058972213,0.002962167,-0.04057949,-0.0036903827,-0.0014814521,-0.0029832216,-0.0020984188,-0.027857702,0.05001532,0.12281102,-0.017941244,-0.1081975,0.049800474,0.04962288,0.030502964,-0.028952789,0.0114425905,-0.06786751,0.021643568,-0.086738266,0.08691495,-0.1104563,0.13392201,0.05523176,-0.043017752,0.016887821,0.13103439,0.0031296974,0.014236227,-0.053245645,0.032585837,-0.01231321,0.019500248,-0.020362189,-0.052283093,0.079936266,0.05018426,0.026127795,-0.030231794,-0.0541055,-0.06335972,0.049599234,0.04305457,0.00083722745,-0.053554963,-0.021596367,0.017334195,0.05123165,0.024945635,-0.01291422,0.050123468,-0.0021431227,-0.014553857,-0.054184534,0.005523262,-0.018359477,0.020081943,-0.0019154126,-0.07490638,-0.020561317,-0.057691738,0.06350525,-0.03227781,-0.015093476,-0.022528728,-0.02000052,-0.009358358,0.076105595,-8.957082e-05,-0.06256296,-0.04098214,0.049232077,-0.0018368965,-0.023542251,0.04015375,0.060727842,0.044490222,0.07948431,0.004039862,-0.03502431,0.037099026,-0.031021452,-0.039244886,-0.025591796,0.057539456,0.03432114,-0.0030876833,-0.026068784,-0.008231399,-0.035129998,0.03729749,-0.06331782,-0.03818285,0.014765411,-0.05528087,-0.0038579663,-0.00061818265,-0.014667028,-0.041727543,0.03289575,-0.028255908,-0.057724487,-0.023454515,0.050189205,0.06771962,-0.052936856,-0.07742227,-0.012250689,-0.027923282,-0.060044557,0.046997204,0.047755916,-0.05921899,0.06829216,-0.012433542,2.8443575e-33,-0.019148696,-0.036036823,0.01959752,-0.0024447404,0.021094546,-0.049520846,-0.07734713,-0.04269004,-0.09849248,-0.019919388,-0.043934133,-0.10005917,0.036194813,0.10834765,-0.06676583,0.06592023,0.063859954,0.028388288,0.11610959,0.00849578,0.03165017,0.053686764,0.04013896,0.0005830144,0.030904172,0.057525612,-0.030524472,0.00082345447,0.10738706,-0.020820847,0.03463796,-0.076683536,-0.048317146,-0.044809774,0.058325984,-0.021390118,-0.08856673,-0.0751071,0.04760553,0.030101467,0.02673726,-0.009291266,-0.018883126,-0.015191632,0.048681665,0.041894104,-0.04958928,-0.00834699,0.014061541,-0.02638046,0.05033931,-0.019343503,0.027199231,0.0084339585,-0.008806929,-0.038123358,-0.035341706,0.045435183,0.059680443,0.0630433,0.0027699831,0.0687761,-0.078642234,0.06405067,-0.009928598,-0.014858251,-0.10611059,0.04068863,0.017355712,0.04818336,0.048395734,-0.0410039,-0.007909905,-0.010802496,0.14180973,-0.028321564,-0.025749765,0.006452361,0.030931612,-0.039971814,0.06769966,0.09655334,-0.055676468,-0.06516434,-0.052366268,-0.0047416873,-0.11401823,-0.061220016,-0.003777077,0.047500435,-0.045381974,-0.06469423,-0.11961752,0.083687745,-0.0670802,-4.846164e-33,0.057035506,-0.13358861,0.0708176,-0.05535755,-0.023475995,0.034804158,0.056683127,-0.012503034,0.09914786,0.08438514,0.010800112,0.01499381,0.002103619,-0.009977252,-0.0327911,0.026814874,0.03399803,0.021330396,-0.024576977,-0.04273094,-0.010819984,0.046398956,0.036340367,-0.031248651,-0.0044075456,0.015655247,-0.04203452,0.068405285,0.018159712,0.10199135,-0.018146524,0.022787068,-0.035120316,-0.050181318,-0.10417567,-0.016086776,-0.04857453,-0.011553443,0.031051999,-0.02565582,-0.048038747,0.08613954,0.029054206,0.010507941,0.03076995,-0.006048435,-0.045228735,0.03657437,-0.07391766,-0.058810964,-0.012625595,0.04421636,0.048642874,0.0032661327,0.056238696,0.028928159,0.06892623,0.015493915,0.090356156,-0.11667551,-0.03104883,-0.09806268,-0.04567951,-0.027226472,0.10795629,0.17047314,0.06407152,0.025770975,0.011239315,-0.06809472,0.03945983,-0.023040388,0.0071445275,-0.008951132,0.07984483,0.020458855,-0.02630006,0.023785753,-0.003520756,-0.00034544128,-0.029037822,-0.054491073,0.016977537,-0.092798,0.0033897962,-0.05945667,0.061536707,0.070051305,-0.013816527,0.0848099,-0.04661933,0.057627775,-0.08302326,0.049641535,0.088996336,-4.1437822e-08,0.024734288,-0.047310222,0.019114466,-0.031522214,-0.010094991,0.02259517,-0.029579878,-0.027095402,0.077417,0.014513764,0.0037979253,0.04342326,0.046332642,-0.029572045,0.023970203,0.04509479,-0.025070768,-0.06733299,0.01469206,-0.05159949,-0.029292548,0.050880875,-0.023073407,0.02777719,-0.021706693,-0.07383761,0.043191597,0.01926595,-0.021743054,-0.024784338,-0.019562863,0.047816128,-0.048803117,-0.10749352,-0.041110966,-0.031462856,-0.016165962,-0.06410327,0.05916376,0.03697143,0.023447607,-0.0029127656,-0.040148273,0.0051487014,-0.057698015,0.04920475,-0.03772064,0.037336998,-0.041147534,0.025695303,0.02130343,-0.011010337,-0.053524837,-0.0041054175,-0.01760196,0.009680072,-0.033043448,-0.04254892,-0.04916777,-0.008148815,-0.009177417,0.013312877,0.14173521,-0.020766191 +3.1.1.91,"This enzyme, characterized from the soil bacterium Bradyrhizobium sp. JS329, is involved in the pathway of 5-nitroanthranilate degradation.",384,1.0,-0.07646757,-0.03850496,-0.06548886,-0.037559528,0.14396073,0.0076758564,-0.08038107,0.028249545,0.022902701,-0.047889944,-0.07350522,-0.026645677,-0.031864226,0.040187165,-0.112481475,0.027135868,-0.111539714,0.016264763,-0.045833718,-0.043196533,0.0017194803,0.09435631,-0.031136163,-0.038762994,0.02340525,0.041831598,0.015539255,-0.028076118,-0.03321756,-0.09017059,0.078902654,-0.00646949,-0.0144602405,-0.06636515,0.07689171,0.13145438,-0.07899207,-0.04430876,0.06619164,0.03283608,0.02045418,-0.02815806,0.051213242,0.0019739338,-0.014585716,0.042657573,-0.026831884,0.018456003,0.06325608,-0.00689691,-0.06605561,-0.055233527,0.0103037385,0.04240275,0.013473367,-0.06340662,0.0023543113,-0.06542024,-0.040229402,0.03227514,0.09621736,0.016946392,0.05582334,-0.008988652,0.00082967343,0.023629803,0.010821975,-0.10541023,0.008543421,0.011395227,-0.11411951,0.010514847,0.015492914,0.04693793,-0.011726821,-0.008602016,-0.039694093,-0.0065356935,0.06731604,-0.06969958,0.02706096,0.049334444,0.03141934,0.06056429,0.005465013,0.014397988,0.0053234254,0.025858127,0.09805197,0.0197422,-0.013909001,0.01919531,0.021910118,0.0068216757,-0.15081553,0.007698221,-0.058776375,-0.012330693,-0.05727872,0.00022421393,-0.051578946,0.031034103,-0.08069497,-0.052269306,-0.10424238,0.023648664,-0.042488694,0.10633672,0.007712551,0.03725334,-0.024213752,0.0005286124,-0.025851816,-0.012380848,0.046303425,0.022144394,0.042180408,-0.013420073,-0.07845684,0.06319307,-0.0073684216,-0.017425474,0.001610439,0.025923533,-0.05721765,0.035807297,-0.05238986,1.0988913e-33,0.023497174,0.009292508,-0.029207768,0.006257346,-0.00014198772,-0.068441845,-0.077557534,-0.012009556,-0.030869199,-0.032885063,-0.0036977401,-0.07667718,-0.007313032,-0.04848564,-0.01939707,0.055068213,-0.052562736,0.030066505,0.0116430605,0.061691165,0.061211064,0.05789828,-0.09763429,0.028733864,0.052050345,0.051487964,0.033620417,0.051924497,0.053373236,-0.040308584,0.044287916,-0.05930876,-0.11002398,-0.021029389,0.11347752,-0.04467751,0.048441906,0.025107443,-0.023218231,0.09451711,-0.028683513,0.05407516,-0.018507676,-0.008324325,0.08117255,-0.022304581,0.018592414,0.14330196,0.07633342,-0.0016438834,0.02439877,-0.037041225,0.1293828,-0.0040657744,-0.038789775,0.012286699,-0.025161931,0.0033386974,0.028916836,-0.01725813,0.05150111,-0.0020292192,0.0026468723,-0.00028891876,0.014465188,-0.034832697,0.02771205,0.008907381,0.077666864,0.09375752,-0.073512025,0.031962566,0.045636054,0.06885731,0.00027962212,-0.09033088,-0.08578732,-0.0079911575,0.036532488,0.03041969,-0.014225403,-0.0941969,-0.007948702,-0.05323306,-0.013715515,0.04761904,-0.029393561,-0.06262444,-0.026062747,0.03404922,0.08970592,-0.08535659,-0.07118147,-0.00044553878,-0.009056564,-1.1847273e-33,0.09916976,-0.00781482,-0.031647764,0.035088,-0.080012515,0.023033336,-0.0346961,0.040061124,-0.0006626109,0.03972332,0.07607662,0.06031047,0.0660816,-0.008419396,0.020201499,-0.03814621,0.02601135,0.017009037,0.0012061974,-0.035948373,0.0129456045,0.05168207,-0.073668085,-0.08570038,0.019037243,0.070849195,-0.0630722,0.1262635,0.038649112,0.008019179,0.027915569,0.0313421,-0.05695245,-0.09167681,-0.020194368,0.03767749,-0.015314251,-0.036147695,0.0039368276,-0.022367025,0.05156525,0.011685255,-0.02188237,0.06137009,-0.0704573,0.050050024,-0.08869932,0.06623471,0.07534784,-0.028954813,-0.019946761,0.042959295,-0.03972847,0.03941454,-0.031306285,0.061339546,-0.007577048,0.04344268,-0.07121676,0.03957025,-0.013560202,-0.01573985,0.024815872,0.012967012,0.040053926,0.08096207,0.0014289045,0.10809996,0.03490544,0.044964466,-0.00088171056,0.027583167,0.11255669,0.07482045,-0.03772229,-0.016613757,0.01900033,-0.017684951,0.008657966,-0.012884378,0.020223936,-0.043197475,-0.020347033,-0.08661192,0.007165242,-0.05825051,0.040663123,0.086539276,0.05595889,0.027268529,0.03358831,-0.037348896,-0.059448063,-0.026634226,-0.04254117,-2.7285266e-08,0.026715335,-0.058766365,0.0045337183,-0.07532956,0.02331359,0.014311843,0.027906008,0.019990893,0.08388909,0.00046803005,0.020434529,0.08032799,-0.021907216,0.016329108,0.03546164,-0.014733738,0.010341652,-0.033252314,-0.02746335,0.026476378,-0.067877896,-0.04883808,-0.09179427,-0.0018188534,0.04408581,-0.05356298,0.04140299,-0.018632172,-0.006496482,-0.025103612,-0.045513313,0.049952712,0.023732794,-0.058530223,-0.06876802,0.10478658,-0.05170845,-0.00919652,0.021963254,0.021109901,-0.006327801,0.010358651,-0.11994488,-0.017750971,-0.0038059754,0.0011159766,-0.08015419,-0.021715414,-0.0256382,-0.035389874,0.0033728557,-0.024026968,-0.03180197,0.022903036,-0.08325662,0.02677638,0.0066498877,-0.057148524,-0.019952543,-0.032551467,-0.05260504,0.0003734607,0.16596231,-0.052065324 +3.1.1.92,The enzyme was isolated from the bacteria Hydrogenophaga intermedia and Agrobacterium radiobacter S2. It catalyses a step in the degradation of 4-sulfocatechol.,384,1.0,-0.001167955,-0.0101891495,-0.13888313,0.023696616,-0.005999884,0.045257933,-0.05040469,0.032393493,0.008622767,-0.013138731,0.013340186,-0.007215501,-0.014859365,0.017845593,-0.08515825,0.06557515,-0.0279849,-0.010964836,-0.043033484,-0.044522546,0.036995962,-0.010644618,-0.067101225,-0.030609438,0.043815628,0.08363008,0.020091513,-0.026517145,-0.09148673,-0.09114163,0.048840035,-0.02695257,0.09962274,-0.06760978,0.10374234,0.0642111,0.006533929,-0.03749868,0.06672512,-0.05891878,-0.00039694278,-0.005101391,-0.03287293,-0.026669987,-0.052827157,-0.026645143,-0.009866473,-0.005565472,0.09088509,-0.10940761,-0.028162725,-0.01380118,-0.019224916,0.049342807,0.026909154,-0.011582511,0.0049034376,0.014475309,-0.029271217,0.042639367,0.015562828,0.0037500027,0.008262133,-0.027532412,-0.00809168,-0.038879227,0.030955354,-0.10451423,0.00870195,0.029462228,-0.1304067,-0.039240584,0.009915163,0.013271546,-0.009883067,-0.01333472,0.06321319,-0.034410555,0.10277604,-0.037044287,-0.0112793185,-0.045482274,0.0014227057,0.038860116,-0.02144473,-0.04279423,0.036724634,-0.039790526,0.10450655,0.03861146,0.0067568063,0.018658468,0.008150125,-0.07003497,0.0058795824,0.03875965,-0.021107724,-0.008093477,0.06497914,-0.016881771,0.04532293,-0.012709064,-0.04578059,-0.16794445,-0.091252424,0.017178882,0.0020358309,0.12706701,0.047444355,-0.008692149,-0.02053895,0.02152782,0.0019676993,-0.0075007817,-0.02676367,0.0918935,0.12646663,-0.018653695,-0.13011098,-0.019201912,-0.03400067,-0.03234995,0.05964198,-0.033874936,0.0073804865,-0.0010423192,-0.072878495,8.798769e-34,0.10067875,0.059005357,0.023822686,-0.058541954,-0.025477521,-0.016768519,-0.059066325,0.03253305,0.010980714,0.009531003,-0.02658564,-0.080891505,-0.016596343,-0.034503303,-0.018212056,0.058686506,-0.01404286,0.042733368,0.016957307,0.00038742824,-0.023295896,0.043631773,-0.014421687,-0.023236755,0.08024113,0.12774275,0.039771974,-0.06616608,0.042073123,0.030415187,0.043370325,-0.067621775,-0.13821469,0.04084541,0.07387909,0.032807373,-0.042725213,0.011236697,0.011664591,0.06336854,0.07611414,0.037649088,0.060680386,-0.022375647,0.04153611,-0.03772696,-0.07326095,0.07059822,0.06034662,0.07056939,-0.042325214,-0.08122638,0.05461028,0.004818355,-0.044444222,0.024340238,-0.0043479516,0.017177375,0.060908835,0.01785142,-0.03996369,0.12902097,-0.042361245,-0.011679476,0.044316232,-0.029389484,-0.042563397,0.01781851,-0.04934092,0.06948694,-0.02965174,-0.015260498,-0.008514739,0.02615122,-0.0031994353,-0.07308957,-0.01868616,0.026785012,0.085326,0.048868142,-0.023451298,-0.06683028,0.02377041,-0.046495408,-0.0713501,0.022111006,-0.05370322,0.015213092,-0.048507117,0.0767288,0.017504023,-0.005403817,-0.07098186,0.007742159,0.016240245,-2.6586984e-33,0.07197704,-0.04151249,0.032275118,-0.059708413,-0.055530738,-0.011237977,-0.036058318,0.025015676,-0.047984995,0.013373534,0.052524768,0.020296507,0.057983764,-0.03587754,-0.028713759,0.036669474,0.06343146,0.025256975,-0.029522559,-0.017862566,0.007513263,0.08028333,0.025805429,0.03009373,0.054837186,-0.0605009,0.061550032,0.022279294,0.09154803,0.0856733,0.014428693,0.029508604,-0.014409116,-0.08166288,-0.018041056,0.007822584,-0.03415908,0.021402994,0.009764265,0.009440499,-0.018469783,1.6460519e-05,-0.0073014,0.051546622,0.019765723,0.025936723,-0.07762726,0.038153686,0.023060115,-0.0014692176,0.045538124,-0.038385954,0.0115377465,-0.04245848,-0.020243226,0.007890013,0.0065046027,-0.027840402,-0.09939773,-0.047915913,-0.051078845,-0.024731688,0.04858025,-0.035612814,0.041663554,0.1354236,0.033174824,-0.007753077,0.01680822,-0.10184504,0.046218324,-0.064338125,-0.014060107,0.023742812,-0.033306245,0.054082297,-0.07564548,0.07591713,0.014720862,0.026320608,0.051770683,0.013798781,0.010860102,-0.129185,0.015536893,-0.08358797,-0.0017392164,0.1352913,-0.05093298,0.0015706783,-0.023809282,0.063802116,-0.031418245,0.07731072,-0.0006925998,-2.8022578e-08,-0.024557054,-0.040478397,0.033402883,0.014745077,-0.0035201928,0.10528305,0.0072954255,0.010907128,0.07506582,0.018677069,-0.09693717,0.08735306,0.012727302,0.026022855,0.03884598,-0.008307047,-0.032634098,-0.05364649,0.0026164039,-0.0011480978,-0.030739093,-0.059683055,-0.10222871,0.040229194,0.023261722,-0.03885671,0.07476902,-0.061518636,-0.020813309,-0.030014262,0.023075275,0.08749204,-0.06752139,-0.016552709,-0.04974235,0.003370038,-0.028191132,-0.06991489,-0.011004913,0.07914487,-0.003463877,0.078202374,-0.06125549,0.009462299,-0.05977902,0.02023872,-0.0038118684,0.037961364,-0.04910642,-0.029502222,0.03985936,-0.017458547,-0.054823343,-0.07568041,-0.073922716,0.081619084,0.112676755,-0.07589033,-0.018551813,-0.015815629,0.0056868824,-0.050883703,0.070672974,0.028764011 +3.1.1.93,"This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.",384,1.0,-0.02398433,-0.010829366,-0.102467254,-0.019205602,0.008835446,-0.022989092,0.0917244,0.16799311,0.017830724,0.0071489625,-0.023333224,0.0109466575,-0.03446809,-0.030364092,-0.09154215,0.1224296,0.07094562,0.020250265,-0.031567678,-0.09235699,-0.05327089,0.0028815244,0.014365967,-0.014330584,0.034870215,0.021289814,-0.00453115,-0.0052972436,-0.015833426,-0.017466776,0.001251509,-0.095972404,0.04080974,0.03319908,0.03812392,0.03215806,-0.053332172,-0.048567608,-0.00010975188,0.03096244,-0.025955781,-0.027370743,-0.05439795,0.024972187,0.008577214,-0.07718571,-0.10191681,0.0543076,0.01703323,0.09982949,-0.027417416,0.004405676,-0.060934193,0.055629417,0.00037257138,0.011695705,-0.03725982,-0.04860259,-0.050085142,0.11125878,-0.024137104,-0.03269889,0.0054139006,0.059338514,0.01854508,-0.00016029991,-0.00962618,-0.055268362,-0.005480725,-0.084841974,0.031629473,-0.10369601,-0.009319383,-0.015663404,-0.0008025102,-0.02843627,-0.061761014,-0.017389596,0.0977733,0.006733216,0.076080404,0.042868238,-0.010015094,0.036084045,0.03107082,-0.034421388,-0.022316264,0.025545519,0.008501157,0.053131398,-0.024099218,-0.09607302,-0.0051243408,-0.010698794,-0.009762064,0.02489,0.070970505,-0.009766696,-0.04224916,-0.02400702,0.024702385,-0.019914886,-0.029684054,-0.09315916,-0.099471755,0.029892717,-0.028016906,0.051560324,0.028374495,0.031723257,-0.073017724,-0.0113951815,-0.0639657,0.023156127,-0.0066924295,0.15179902,0.076006785,-0.008475823,-0.009373113,-0.03324756,-0.030846428,-0.020590618,-0.04220592,0.011801054,-0.050365727,0.01275978,0.04176566,4.111171e-33,0.08928413,0.01892173,0.007074156,0.019442283,0.00056003255,0.052163053,-0.08191674,0.028053613,-0.027713249,-0.04909617,-0.051535543,-0.037835654,-0.032019343,0.1319634,-0.036983866,0.056145724,-0.03173651,-0.033213995,0.098188736,0.005469973,0.032130882,-0.06721791,-0.01236481,0.03360933,-0.029098518,0.092338204,-0.10987089,0.061862394,-0.053066764,0.010775682,-0.04652689,-0.032098953,-0.022626558,0.021673448,-0.037280742,0.0033043618,-0.07889257,-0.07269398,0.0077911066,0.06441326,0.017569065,-0.042968508,0.016230807,-0.061687328,0.080821596,-0.03691784,-0.08281512,-0.03093126,-0.0677136,0.101501755,0.042167414,-0.031320192,0.041560877,0.0001252415,-0.009270035,0.038500573,-0.06507052,0.03326838,0.013366429,0.0043640956,0.01954031,0.049953252,-0.023463959,0.099845864,-0.048207007,-0.040062655,-0.1087961,-0.0007318834,-0.07083684,0.043922365,-0.004764926,-0.06288583,-0.03489211,-0.005066709,0.046172753,-0.06995947,-0.031717442,-0.0029274612,-0.06848905,-0.00019968911,0.0029395542,0.020683007,0.004928957,0.020044943,-0.047998536,0.046393786,0.0053962357,-0.030502615,-0.019665593,-0.04314077,-0.09457027,-0.023100054,-0.03453567,0.050741687,0.0022903432,-6.704966e-33,0.02311361,-0.12882072,0.05678747,-0.05510503,-0.011964998,0.018738322,0.03382459,-5.248978e-05,0.11291317,0.08635582,0.032410704,0.011969524,-0.021881415,-0.048853412,0.041444995,-0.044526044,-0.007549202,0.07082088,-0.049631506,-0.01326887,-0.025914451,0.06858899,0.04348565,-0.045432735,0.031381745,-0.052792314,0.0021904553,-0.06428111,0.08948062,0.09719427,0.01566377,0.073982604,-0.0026085845,0.017651705,0.08053822,-0.0033681337,-0.032354064,-0.06683867,-0.03977619,0.020125667,0.01900246,0.05458832,-0.007111569,0.03985939,0.06985356,0.018199852,-0.099654436,-0.03636053,0.012138542,-0.053106755,-0.032775804,0.010905841,0.008868049,0.055264425,0.05253653,0.02623748,0.017912367,-0.053362384,0.013131351,-0.06715519,-0.06245441,-0.02039631,0.01858002,-0.011140428,0.07449977,0.027090788,0.029645678,0.056861933,0.022035178,0.009951482,0.09029724,-0.0019409938,-0.08672781,0.112216376,-0.04418151,-0.09093464,-0.016776497,0.09452155,0.020501534,-0.035926517,0.022221593,-0.08275639,0.013076001,-0.021839589,0.022682779,-0.09105939,-0.09141518,0.15235496,0.012632844,0.05140008,0.00043421512,0.07270497,-0.13129511,0.018572137,-0.0099193435,-3.441572e-08,0.0708132,-0.04453605,0.0073482455,-0.009627909,-0.006961691,-0.008913677,0.0335929,-0.018572161,0.0056584645,-0.008661422,0.026152803,0.092226826,0.010859418,-0.032800995,-0.046173636,0.052667044,0.0054968563,-0.015843865,0.04992894,0.024686266,-0.058404885,-0.03227923,0.0016179621,0.013971107,-0.012651719,-0.056426816,0.06288921,0.03610121,0.04398751,0.013325068,0.012837835,0.042696487,0.01382053,-0.0440408,-0.052755512,-0.00065769383,0.035197362,-0.036204275,-0.034391765,-0.005386585,-0.018474223,0.010479013,0.018870788,-0.0108539425,0.020774687,0.029712638,0.07146485,-0.020610666,-0.023936052,0.119845726,-0.06772819,-0.0023245858,-0.019009294,-0.019326676,-0.061909046,-0.032073867,0.0031667969,-0.03311609,0.014304739,-0.15233564,0.031559885,0.080254324,0.1277507,-0.031492632 +3.1.3.88,"Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. No metal is required for activity.",384,1.0,0.023966542,-0.031868488,-0.043827996,-0.027622068,-0.012595999,0.014683057,-0.06309254,0.054636493,0.07714832,-0.007807486,-0.05589004,0.024480404,0.1449406,0.12362506,-0.047790132,-0.040353816,-0.018787758,0.034959808,-0.037290365,0.037099622,0.011561237,0.074934185,0.058500875,-0.020137439,-0.026249966,0.029969288,-0.021056667,0.034870986,-0.00635619,0.022356117,0.033681598,-0.033499707,0.008993502,-0.050346598,0.054337565,0.049850725,-0.05515992,0.05650518,0.0854412,0.044122003,-0.07717783,-0.028330987,-0.028973415,-0.008247053,0.035675,-0.06831288,0.033546444,-0.02422251,0.032712497,0.08479045,-0.035058014,0.03840529,-0.016243575,0.038501684,0.071394034,0.061027315,-0.032094058,-0.091692574,-0.010253906,-0.06333865,0.028158937,-0.06673728,0.022663282,0.018135753,-0.09702208,-0.0023875784,-0.012723284,-0.04521539,0.07648341,0.0065031564,-0.012466691,-0.11705976,0.035094466,0.06858915,-0.011005435,-0.04509122,0.09994357,-0.056886382,-0.053969618,-0.07500007,0.0072851293,-0.007558287,-0.0005014021,0.065749265,0.062957965,0.08344691,0.07790882,0.016112635,-0.029403161,0.06658624,0.07217314,-0.010846836,0.02225883,-0.11501568,-0.0237257,-0.07584832,-0.017374983,0.007872725,-0.03171471,-0.040941883,-0.012869952,0.0048017534,-0.02973629,-0.04035775,0.023496252,-0.0061540063,0.012906181,0.04259784,-0.062365506,-0.01526813,0.009177717,-0.037894957,-0.04968818,0.016964223,-0.0085340105,0.07976104,0.12638491,-0.044976715,-0.102393955,0.06247594,-0.026199384,-0.024153514,0.0037938415,0.014144752,-0.05370678,-0.0030986564,-0.009929762,1.3128484e-33,0.02063594,0.053976625,0.016307756,-0.029153781,0.04063349,0.023515934,-0.037581965,-0.06498684,0.1030323,-0.031839322,-0.08005719,-0.053584494,0.04484221,0.0045445454,-0.022578217,-0.041304838,0.0019684995,-0.0463072,0.005426808,-0.013649298,0.013538825,0.056237154,-0.013735321,0.061905246,0.031654876,0.042319622,-0.017560547,-0.008312598,0.04642045,-0.03397332,-0.057491913,-0.01591108,-0.035357747,-0.022103295,0.04537329,0.038978975,-0.021411384,-0.012505223,0.103766635,0.02392833,-0.026233766,0.025218977,-0.09662214,0.025682304,0.10001467,-0.013741217,-0.06894521,0.10789828,-0.0717059,0.018594027,0.1159125,-0.03991858,0.054188903,-0.09670533,-0.049980618,0.007089948,-0.058056023,-0.0046827276,0.016723303,0.04909541,0.017525058,-0.0518499,0.015567778,0.04816268,0.067883015,-0.0071160267,-0.03470569,-0.048859652,-0.05387889,-0.010545522,-0.09451283,-0.0019594308,0.07024819,0.062887385,0.0053343847,0.050855253,-0.09107519,-0.036089774,0.11285829,-0.008217358,0.019178515,-0.024052594,-0.056300607,0.01694132,0.024918938,0.025152668,0.03199453,-0.058364555,0.032087713,0.015198473,0.010409842,-0.08563675,-0.097871944,0.0017007571,-0.018277667,-5.089516e-33,0.094653286,-0.044257205,0.08457827,-0.021254797,-0.016066864,0.07884094,-0.0762537,-0.1235809,0.084969215,-0.024215912,0.09842682,-0.023920242,-0.053475562,-0.06705335,-0.0619401,0.008411953,-0.040974803,0.055758193,-0.03759641,0.032867737,0.0054581463,-0.035270482,-0.038865283,-0.010656245,-0.0044803303,0.067623265,-0.07852332,-0.0014369895,0.023662644,0.10508619,0.026098028,-0.009920797,-0.023197396,-0.15841721,0.013150584,0.12230522,-0.029160364,0.01593519,-0.05212205,-0.03806147,-0.026823973,0.009036583,0.011473963,0.12895146,-0.0263388,0.0021123718,-0.0811922,-0.0430836,-0.011743691,-0.089124724,0.040402565,-0.023493515,0.042732853,0.017651614,0.0017385688,0.023775004,0.009946864,-0.029833388,0.047911633,0.0024758426,-0.0079074465,0.010823846,-0.029428566,-0.034042154,-0.03014509,-0.012534078,0.014835354,-0.0016038097,0.03551972,-0.064470895,0.0004876308,0.005621185,0.061025195,-0.006660045,0.008043662,0.037244886,-0.020100672,-0.115187876,-0.028058607,0.04666143,-0.05496677,0.07450003,-0.061400924,0.017464643,0.008681344,-0.042368818,0.07256635,0.01983099,-0.053790633,-0.043794446,0.0017816252,0.016654521,0.0069287824,0.016359871,-0.01833338,-3.3261426e-08,0.05493437,0.05501977,0.059367996,-0.058230497,-0.018677287,0.008086239,-0.051491503,-0.0810786,0.024213254,-0.009435334,0.01653736,0.120147265,-0.012342932,-0.040455017,-0.0154098645,0.06433652,-0.040163405,-0.024247508,0.011255168,-0.059898578,-0.11500888,-0.013584111,-0.058771677,-0.022476139,0.08112826,-0.008359502,0.031633623,-0.012563889,-0.039032124,0.02755931,0.07641493,-0.039376803,0.024032224,-0.014137718,-0.047607727,-0.020936657,-0.00023815269,-0.020542834,0.032842178,-0.06825848,0.009259869,-0.0152596235,-0.061860163,0.030821126,-0.034628462,-0.0033147694,-0.0407644,0.05911972,-0.07566769,-0.02627296,0.015329136,-0.023631848,-0.01781341,-0.04216929,-0.087841064,0.0971124,0.020410558,-0.052300047,-0.00093650544,-0.06599127,-0.11030888,-0.048087128,0.109671704,-0.041241106 +3.2.1.181,"The enzyme from the fungus Flammulina velutipes (winter mushroom) hydrolyses the beta(1->3) bonds found in type II plant arabinogalactans, which occur in cell walls of dicots and cereals. The enzyme is an endohydrolase, and requires at least 3 contiguous beta-1,3-residues. cf. EC 3.2.1.89, arabinogalactan endo-beta-1,4-galactanase and EC 3.2.1.145, galactan 1,3-beta-galactosidase. +",384,0.99999994,0.021441042,-0.048109904,-0.095389135,-0.0008157503,0.087489925,0.036087736,-0.0764076,0.006451712,0.08612678,-0.013805314,0.088552035,-0.025033915,-0.047649387,-0.0006447617,-0.093470216,-0.025248483,-0.029046815,0.04350041,0.017830482,-0.008071671,0.08741538,0.03885843,-0.0019675684,0.049671423,0.08391228,-0.00043466006,0.013077797,-0.036028873,-0.030934274,-0.13291797,-0.007254643,-0.0053872652,0.04804332,-0.02775817,-0.00012458538,0.10902545,-0.03816952,-0.08060562,0.06241618,-0.008982757,0.05381076,-0.049445935,0.08827971,-0.049481478,-0.02412106,-0.00783975,-0.055415105,0.05508841,0.12754653,-0.006679302,0.009430241,-0.1144659,-0.040085975,0.04061765,0.03215824,0.042780116,0.011831261,-0.013004174,-0.05455538,0.10684298,0.06761109,0.054677043,-0.012471405,-0.014144238,-0.02838108,-0.022603814,-0.02813431,-0.049638327,-0.02490951,-0.03559764,-0.04210664,-0.009914889,-0.045122493,-0.0056779473,0.007088264,0.031047208,-0.093783796,0.00681947,0.010773737,0.019419644,0.016127218,-0.03532492,0.054017857,0.0013906221,-0.013927793,-0.050596774,-0.018234368,0.058275476,0.055471387,0.06423264,0.057776336,0.03690469,-0.046901986,0.033224307,-0.042412236,0.052928224,0.03996876,0.006772037,-0.0015485295,-0.033474576,0.034861267,-0.06757073,0.052342862,-0.061679468,0.0014218206,0.018887948,-0.013937108,0.0066942587,0.036248725,-0.039367326,-0.0073607615,-0.043754164,0.048448775,-0.044800173,-0.023526752,-0.017608939,0.0067330254,-0.0683081,-0.07368606,-0.019636342,0.023131482,0.012482781,0.026969977,0.028025588,0.023867542,0.015978092,-0.1263429,4.7955963e-34,0.066716984,0.00015693216,-0.04276036,0.022918593,0.0035234066,-0.03673341,-0.015575369,0.0023387799,-0.061519414,-0.03884322,-0.09528483,-0.000677639,-0.061202172,0.040505555,0.05559076,0.039623726,0.0315309,-0.055597953,0.060781676,0.04200882,0.009416343,0.013293712,-0.047185406,-0.039318334,0.08457494,0.061916124,0.010574022,-0.04016837,0.08436641,0.019038748,0.092507705,-0.07295358,-0.0940703,0.069049686,0.07532089,0.05937701,-0.033018477,-0.021515207,-0.04104567,-0.052724693,0.070514604,0.037600417,0.0012978886,-0.019427499,0.05520462,-0.024026211,0.047988493,0.06681876,0.06024963,0.042184938,0.08144984,0.015943771,0.07079021,0.014848967,-0.017176492,0.060101353,-0.05908042,0.05600844,-0.062749796,0.08823154,-0.08222217,0.07064678,-0.050963905,0.016096652,-0.058297954,0.057232257,-0.077162206,-0.008417422,0.00035544584,-0.0036827456,-0.025922641,-0.045968026,-0.0023433731,0.037477627,-0.0070177373,-0.043613173,-0.0134076495,-0.019903967,0.0060135936,-0.01278565,0.06756295,-0.012527732,0.0057066465,-0.015136934,-0.11327809,0.06293262,0.016965963,-0.009396777,-0.00868661,0.051809255,0.059344374,-0.029294727,-0.025245052,0.088549614,0.048637003,-1.7241102e-33,0.12338655,-0.12796356,0.040828545,-0.05612902,-0.020411886,0.07255266,0.0002857336,-0.03764021,0.027289012,-0.012813039,0.009149102,0.00388476,-0.021159848,-0.076424524,0.018216683,-0.01085437,0.026368175,0.08623952,0.0033201172,-0.082438014,-0.0741069,0.07104839,0.054122694,-0.012374387,0.021387285,-0.022958817,0.044074293,0.0704793,-0.045199215,0.008507658,-0.024306608,-0.0130356485,-0.02057896,-0.03576906,-0.09348949,0.023021191,-0.054863375,-0.058430467,0.05358347,0.043368787,0.039106254,0.023781888,0.016148416,-0.0059853727,0.052858047,0.0763378,-0.06353833,0.035055175,0.034879297,-0.062900715,-0.020008806,-0.04853446,0.0003608228,0.011259559,0.05397366,-0.029365132,-0.012298226,0.08252306,0.029115915,-0.058522858,-0.015496932,-0.03126743,0.008346644,-0.027624644,0.046097454,0.010378678,-0.006289047,0.0056317085,0.01723262,0.029430248,0.09704034,0.039467487,-0.014282099,0.06264188,0.014024236,0.043858457,-0.08755767,-0.062400643,-0.024077432,-0.043644678,0.021615364,0.033172075,0.00031484535,-0.051450163,0.049244877,-0.11352572,0.09632077,0.1366126,-0.06541419,0.058240786,-0.01223513,0.025102252,-0.035510313,0.04823957,0.10375597,-4.0986798e-08,0.032053024,-0.01980964,-0.018433444,-0.1407552,-0.0232437,0.03939177,0.095132396,0.055155292,0.040087312,-0.029809697,-0.050833616,0.103051454,-0.02294615,0.0772822,-0.0052240095,-0.0079812035,-0.0041679884,-0.012048983,-0.0074409535,0.016559787,-0.06626339,-0.024738036,-0.088881716,0.0055134953,-0.05991257,-0.03544041,0.024779242,0.051123224,0.0049442863,0.0612248,0.0032559244,0.022887511,-0.025382629,-0.10522951,-0.087152705,0.0134787895,-0.06519216,-0.026123028,0.00907731,0.04533452,0.029420879,-0.07569607,-0.015664143,-0.045955785,-0.04832983,-0.043443024,0.01021505,0.05539172,0.00058432634,0.004685987,0.08993951,-0.03524629,-0.08617475,-0.053490266,-0.09740948,-0.056847576,0.056117587,-0.028469095,-0.02942644,-0.05012337,-0.060461603,-0.044609766,0.13226233,-0.005191619 +3.5.99.9,The enzyme catalyses the initial step in the biodegradation of 2-nitroimidazole by the soil bacterium Mycobacterium sp. JS330,384,0.99999994,-0.01566583,-0.033143654,-0.051306106,-0.06199634,0.043789156,-0.051373754,-0.024771582,0.06791282,-0.016919682,0.012792902,-0.059868332,0.010968693,0.011826477,0.05815165,-0.07010949,0.05069606,-0.01729076,0.018856172,-0.010571705,-0.003413758,0.047893908,0.044313863,-0.0014359438,-0.06970957,-0.00068843464,0.05491185,0.021340158,0.02557049,-0.009207349,-0.0980436,0.04135016,-0.028673213,0.07114044,-0.086884744,0.14180373,0.06395266,-0.023197241,-0.06669191,0.055897627,-0.019688599,0.011903602,0.005886704,0.03721135,0.00023066827,-0.015729593,0.02450731,0.018135231,-0.0018932985,0.03634209,-0.073123015,-0.08614174,0.0073033036,-0.002894533,-0.0022335262,0.051851667,-0.0047192713,0.011378997,-0.043271147,-0.018137021,0.05162887,0.10357749,0.0339621,0.03568592,0.007932742,-0.0058687413,-0.06546409,0.019025814,-0.035863865,-0.013280339,0.042999636,-0.11218926,-0.017974498,0.011312819,-0.018304277,0.012674063,-0.034377716,0.03942492,-0.007657365,0.01499082,-0.054971,-0.05541589,-0.046501573,0.0002672247,-0.07853131,-0.0027846657,-0.02709006,0.058882598,0.006627921,0.10957048,0.08130731,0.006476171,0.0045763296,0.08668094,0.026329514,-0.09587484,-0.008688297,-0.031321667,0.040193904,0.0006225166,-0.026921473,0.017217066,-0.0019284827,-0.007998677,-0.050637264,-0.048564795,0.021820722,-0.018129967,0.06713512,0.077679865,0.10408777,-0.039325554,0.069507286,0.017918425,0.0068281195,0.0058595166,0.03433405,0.10591338,0.0063401703,-0.08066689,0.05154513,0.008047703,-0.056518663,-0.005631317,-0.025852863,-0.102905385,0.09515473,-0.01603442,1.6017942e-33,-0.0037885872,-0.027337322,-0.071615554,-0.04135133,-0.011810338,-0.05239788,-0.11296783,-0.014401156,-0.039229598,-0.023497008,-0.030068917,-0.12779792,-0.022144249,0.059239678,-0.076247804,0.07164959,-0.042426545,0.022359693,0.062614076,0.06814684,0.004736058,0.024640653,-0.070112735,0.024123477,0.042482,0.017922714,0.033592854,-0.018938538,0.023752159,-0.043320317,0.037924163,-0.13334869,-0.13098367,-0.010137353,0.105271034,-0.020626316,0.041704655,0.035818238,0.012514629,0.018365398,-0.0026938957,0.013921419,0.004533866,-0.027248528,0.060017582,0.022316594,-0.029629137,0.096705765,0.069761954,-0.015612194,-0.0054176603,-0.05040811,0.05468281,0.00998378,-0.02621744,0.03356522,-0.011869939,0.022237286,0.12510006,-0.040644456,-0.03768063,0.028654793,0.027657248,0.041752834,0.028439824,-0.10385426,0.014655693,0.102567635,0.09289841,0.10848942,-0.12097357,-0.011090572,0.026857767,0.031036617,0.05536007,-0.1247257,-0.07081226,-0.016194886,0.08495325,-0.025618447,0.06540133,0.0394663,-0.047688067,-0.07347192,-0.0022168998,0.038603496,-0.111417614,-0.013861813,-0.026562724,-0.011712102,0.05311955,-0.071796015,-0.03694145,-0.0053717857,-0.043338586,-3.3284854e-33,0.09238398,0.015186251,0.008680334,-0.015957115,-0.06276438,-0.08933835,-0.0017254055,0.05719814,-0.03569422,-0.005974075,0.02035326,0.0021163067,0.07938049,0.016062366,-0.030610347,-0.03136837,0.00992687,0.032094005,-0.03365025,-0.08060919,-0.06211105,0.06773048,-0.064584285,-0.07713741,-0.042402893,0.024739858,-0.00657406,0.110670544,0.08000862,0.04109793,-0.004334246,0.05869362,-0.10644973,-0.09857537,-0.01759422,0.039836045,-0.06536148,-0.10250272,-0.008682636,-0.024309028,0.04035844,0.06913655,-0.033025634,-0.009466473,-0.05488263,-0.007315563,-0.11236612,-0.011713413,0.064095184,-0.06764576,0.0051172087,0.0755693,-0.0032228287,0.008125171,0.047734838,-0.04012573,0.067365,0.00366009,-0.032131042,0.026987635,-0.05137401,0.011821422,0.056546744,-0.00860209,0.011424107,0.053376514,-0.0516235,0.104325734,0.0055045364,0.026777968,-0.028592786,0.078205846,0.08233813,0.03289125,-0.027737,-0.02658903,0.020672034,0.049334317,0.017275672,-0.050394114,0.06158991,-0.060077522,0.03864977,-0.09855628,-0.010066086,-0.05536185,0.016967501,0.081196785,-0.007383119,-0.007916468,0.035166208,-0.021998009,-0.03923196,0.02743768,-0.048170473,-2.6846008e-08,-0.0088415,-0.030178072,0.074624114,-0.014198378,0.04292968,0.078494474,-0.02426275,0.031771917,0.12506221,-0.0133525,0.005930748,0.059914783,0.000588591,0.013372187,-0.021234632,0.053115375,-0.04395382,-0.113551795,0.014800046,0.025252787,-0.055225957,-0.014769577,-0.075206295,0.060251903,0.08064819,-0.048249137,0.037150197,0.0085169915,0.0026484057,-0.0074505443,-0.053641126,0.057733398,0.013964152,-0.033864032,-0.020917773,-0.01143325,0.01364834,-0.02883995,0.025657374,-0.004308174,-0.022635723,-0.00013380514,-0.07894505,-0.026257109,-0.032806374,0.030239,-0.049142115,0.032109678,-0.055326916,-0.037061915,0.031179076,-0.031135868,-0.026376335,0.020254271,-0.015180581,0.023696607,-0.017102774,0.04088666,-0.057372,-0.028303808,-0.02778584,0.0055824416,0.092498004,-0.052520424 +3.7.1.19,"The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation.",384,0.99999994,-0.062513016,0.024175229,-0.029496238,-0.012338243,0.015899235,0.060399745,-0.050388254,0.020912226,0.052713633,0.027607406,-0.03895331,-0.05172813,-0.092600815,-0.010441102,-0.016895795,0.03516166,-0.052494112,0.07196033,-0.0070077353,-0.0026093905,0.042796392,0.0844438,-0.033165675,-0.0235493,-0.023018105,0.02437249,-0.07050656,-0.029556204,-0.019983254,-0.0014351363,-0.012641773,-0.054217525,0.055856932,0.022483103,0.028839918,0.05106283,-0.064484596,-0.059746772,0.022859924,-0.0022416417,0.0015354421,0.07314815,-0.05202036,-0.0151655255,-0.04068193,0.04584015,0.029145861,-0.016829617,0.01026289,-0.025556888,0.0019207397,-0.012992113,-0.052203186,0.0037796975,0.0013804605,-0.031106897,0.010540695,-0.032525,-0.02763359,0.045812115,0.09586159,0.03812644,0.038890082,-0.010673117,0.018742714,-0.07291829,0.04764086,-0.024800956,-0.015402247,-0.05946689,-0.13928829,-0.06809867,-0.050739683,0.046575896,0.014291735,0.030244658,-0.13561372,0.008213445,0.07732559,-0.054511037,0.048164036,-0.03057275,-0.043527175,0.13352802,-0.023910724,-0.04315156,0.048896298,-0.021200826,0.15050726,-0.030459981,0.028245624,0.022570662,-0.012220043,-0.004444279,-0.1234108,-0.03626045,0.08675037,0.024411233,-0.04396661,-0.013527966,-0.011020647,0.0380356,0.0043870746,-0.1172562,-0.051974554,0.019843487,-0.018698053,0.0018512753,0.08271878,0.069148146,-0.021891547,0.030063815,-0.04314357,-0.03552386,0.008365991,0.06317347,0.004208258,-0.01611164,-0.032501698,0.021279283,-0.05752048,-0.039660115,0.06945211,0.030903196,0.02891243,-0.042460807,-0.060181364,-1.3487918e-33,-0.0007780674,0.0006352068,0.01297679,0.025886158,0.057084057,-0.025365619,-0.0118092,0.023201628,0.028438382,-0.04079991,-0.016765706,-0.11744347,-0.0065352675,0.07775067,0.01909336,0.09408857,-0.07515549,-0.0752786,0.041624956,0.034817357,0.03418223,-0.0034039144,-0.06086822,0.079493366,-0.019704944,0.03603952,-0.063023195,0.006899168,-0.0647154,-0.03413602,0.0959984,-0.03787908,-0.13273112,-0.10011669,0.08787668,0.060511995,0.041336995,0.030518603,-0.10195323,0.0073733353,0.038642332,-0.0108525,0.070135176,-0.039419137,0.051942185,-0.049785223,-0.06350757,0.06175623,0.10185791,0.04416407,-0.041278258,-0.0863646,0.14320268,-0.021028055,-0.054110207,0.08849902,0.037028242,-0.0132669415,-0.047900792,0.018670214,0.0018011364,0.038341198,-0.009069254,0.06584435,0.021031749,-0.013774233,-0.02719216,-0.057952546,0.07101195,0.09971801,-0.036813173,-0.037393373,0.0314553,-0.025592422,-0.033198047,-0.070804365,-0.13478039,0.055448033,-0.01967458,0.04506934,-0.032402836,-0.11065241,-0.0026435335,-0.06086174,-0.039375708,-0.039269123,0.06948135,-0.058721397,0.02605183,0.055783253,0.05429458,-0.031095233,-0.024080867,0.033370752,-0.03239241,-6.291722e-34,0.046568397,0.0013319575,0.02699951,0.024750693,0.0016723567,0.036472537,-0.010340314,0.061335072,-0.054295048,0.011277349,0.030732952,0.026863048,0.09650025,0.014994007,0.029975472,0.031725753,0.01298539,0.014741887,-0.001537926,0.02652089,-0.085052416,0.061745346,-0.0058949604,-0.05133546,-0.011421747,-0.014405085,0.009871728,0.10720147,0.041291513,-0.07783627,0.06685597,0.080685765,0.0060940124,-0.058292232,-0.045285083,0.04127182,-0.012594881,-0.07220084,0.0051898942,-0.009194095,0.07243418,-0.02064156,-0.061285727,0.04012408,0.020967955,0.02610157,-0.054963883,0.023319306,0.014998911,-0.016496334,0.101395436,0.018214485,-0.060699575,0.04324545,0.0594365,0.060632057,-0.062925614,0.024400434,-0.04796961,0.019983983,-0.021128988,-0.007767933,0.0001430675,0.0015674616,0.01695866,0.067302205,0.014322398,0.06559108,0.041891776,-0.03472405,0.034588676,0.038133822,0.09435831,0.036710557,-0.060027603,-0.061708935,-0.024974028,0.0131401345,0.014377255,-0.0748986,-0.01848063,-0.011282926,0.030284526,-0.07890522,-0.004037841,-0.06289428,-0.08549931,0.04804936,-0.027499147,0.041366976,0.0017959978,-0.0692423,-0.041655138,0.016533857,-0.0063244696,-2.4353454e-08,0.03848646,-0.02658895,0.039201457,-0.032637447,0.03952995,0.0072597316,0.05856244,0.052848283,0.042387933,0.034738194,0.022393297,0.0756223,-0.0367362,0.057815786,0.044612896,0.041889332,-0.035429396,0.03821624,-0.04528746,0.09084437,-0.09680761,0.011673585,-0.043994036,-0.025080508,0.06166958,-0.049437005,0.004921152,-0.035741452,0.0261644,0.02183176,0.018334407,0.03320804,0.026342576,-0.038285144,-0.13336605,-0.0030807934,-0.036762755,-0.09100292,0.0052616387,0.029553967,0.011170731,0.02789498,-0.1433917,-0.01632151,0.042336576,-0.019812612,-0.052136235,0.043188576,-0.041754466,-0.030445963,-0.020402852,0.033151925,-0.0012966373,-0.046490744,-0.12240216,-0.045621753,0.017122092,0.0030278638,0.017579546,-0.004878521,0.03729007,-0.022801656,0.13938963,-0.006311363 +4.1.1.95,Binds pyridoxal 5'-phosphate. Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. Has very low activity with substrates not bound to an acyl-carrier protein.,384,1.0,-0.06484615,-0.045165144,-0.073659144,-0.05784732,0.037844412,0.062818825,-0.055473685,0.008102261,0.10030793,0.025415331,0.041480973,0.05959385,0.008073687,0.08413996,-0.05889555,0.031071758,-0.10293527,0.021416351,-0.027081614,-0.053748608,0.070195556,0.013549197,0.008154067,-0.030400293,-0.010985578,0.0706952,0.013022349,0.061390653,0.04492743,-0.07453677,-0.041643035,-0.0066773943,-0.04166282,-0.05845387,-0.0058336305,0.07307092,-0.03660948,0.005784771,0.12857167,0.011416058,0.0043108044,-0.04175755,-0.05356357,0.026261276,-0.087814376,-0.067636766,0.052343015,0.10302896,0.020519845,-0.027392885,-0.04467219,0.064806014,-0.070128195,-0.033413973,-0.024687504,0.062547855,0.0036462394,-0.024044162,-0.066743076,-0.058874488,0.05782534,-0.01984296,-0.011123702,0.049086083,-0.08169019,-0.03917213,0.01798642,-0.021549327,-0.01887209,0.01078335,-0.067346945,-0.08771132,0.0843376,0.037976403,0.07067392,0.029622529,-0.029986197,-0.019280551,-0.07607132,-0.059685893,0.013707674,-0.028330805,-0.004128391,0.124903955,0.08629095,-0.028541386,0.043629374,-0.0058521535,0.03889348,-0.0115983775,0.01687206,-0.057547893,0.019989097,-0.021872245,-0.059331246,0.0020079948,0.02968198,0.034186654,-0.05135818,-0.050023295,-0.001989216,0.029644337,-0.04500995,-0.06199041,-0.03006945,-0.018228805,-0.026594225,0.006395569,-0.0066344487,-0.034978297,-0.07322366,0.0020969878,-0.0035825304,0.032845896,-0.01087769,0.034586668,0.039282553,-0.013547302,-0.102124356,0.002577565,-0.0045885053,-0.02387111,-0.06120587,0.11399663,-0.056757905,-0.017068043,-0.09809172,1.2893623e-33,0.04289101,0.09701068,-0.012348992,0.033613916,0.03432459,0.020300623,-0.05680629,-0.056171015,-0.10601467,0.05739416,0.0030377686,-0.056390285,0.023332888,0.025172953,-0.031752594,-0.07072357,-0.025386728,0.027396332,0.034061182,0.015316508,0.013608967,0.057567872,-0.061540388,0.021569926,0.0346962,0.14476588,-0.033133347,0.054624043,0.056836277,-0.009516214,-0.0072718686,-0.052951507,-0.08173042,-0.036420766,0.05896064,-0.0540681,-0.0098683,-0.048237465,0.019766212,-0.011909091,-0.012531728,0.00720301,-0.09880745,-0.0020035643,0.039152034,-0.050961193,-0.035103388,0.11296774,0.0025766473,0.03570723,0.047225863,-0.093857415,0.114052735,0.024327166,-0.07451825,-0.013408274,-0.098537706,-0.0499558,-0.014586642,0.058700766,0.05253206,-0.043787695,-0.024356993,0.0071539064,0.013344027,0.0021069106,0.0354863,-0.054376468,0.045642268,0.10749862,-0.04074881,0.06960224,0.047017746,0.058233228,0.010181215,0.035510458,-0.06944889,0.012893688,0.08542907,0.054481853,-0.010131805,-0.054993887,0.004828013,-0.029049791,-0.048605684,-0.049198095,-0.024452625,-0.061028395,-0.022930162,0.05846558,-0.0025606318,-0.10113639,0.011570672,0.046255607,0.037764404,-3.1008836e-33,0.08036583,-0.10333441,0.07582392,-0.066951476,-0.08327328,0.0532315,0.04991032,-0.050789,0.027375586,-0.017137809,0.03942185,0.0023045854,-0.019745938,-0.035296954,0.0057956185,0.0410237,0.04639585,0.03755264,0.04531676,-0.0071292794,0.017948993,-0.018774908,-0.02093973,0.11246748,0.016879916,0.100816965,-0.01256737,0.015472565,-0.029236482,0.053738248,0.028322324,-0.020907642,-0.05535991,-0.100090176,-0.042822625,0.085203074,-0.08950642,0.05514587,-0.03470368,-0.020779887,0.03125872,0.04605268,0.013054688,0.006165929,0.0254671,-0.0021104307,-0.026091302,0.011786295,0.035205577,-0.13757189,0.05487042,0.043019645,0.013620351,-0.019603608,0.060715385,0.056298062,0.0105708735,-0.03712116,0.060218178,-0.026289957,-0.04164929,-0.025320379,-0.017976409,0.03866997,-0.04427799,0.05767142,0.020757658,-0.03318241,0.066812865,0.04365459,0.036172684,-0.006555129,0.037138496,0.04337687,-0.06635207,0.029711457,-0.02416311,-0.063001804,0.008606445,0.026354408,-0.041008532,-0.04564845,-0.071366504,-0.05237401,-0.061687496,-0.026540635,0.07514263,0.06889471,0.059105847,0.013506799,0.040947594,0.029237611,0.014986389,-0.014252746,0.045936063,-3.2268527e-08,0.099203594,-0.063325755,0.07478746,-0.028600328,-0.043273736,0.045580465,0.006618553,-0.05270017,0.080982864,-0.009915067,0.031705763,0.01090534,0.041893758,0.02730923,0.059537068,0.07092401,-0.0016264279,-0.003804799,0.03707259,-0.06972045,-0.11113004,0.030976173,-0.09525295,-0.00065140333,0.07498403,-0.06563894,0.007556516,-0.032341298,0.006818436,0.009270003,0.07666662,-0.0309959,-0.03434596,0.014440522,0.009337103,0.0131764,-0.034745675,-0.03191347,0.00040533504,-0.0065109623,-0.009900019,0.015712108,-0.022354472,0.005153917,0.013358578,0.08049414,-0.045562323,-0.014778173,-0.06309754,0.014252746,0.02626337,0.011311791,-0.004917817,-0.08979866,-0.12849288,0.03609943,0.008377252,-0.049161144,-0.027803408,-0.07803989,-0.09470497,0.0026735323,0.1228521,-0.050026998 +4.1.1.96,A pyridoxal 5'-phosphate enzyme. Part of a bacterial polyamine biosynthesis pathway. The enzyme is essential for biofilm formation in the bacterium Vibrio cholerae [1]. The enzyme from Campylobacter jejuni only produces spermidine in vivo even though it shows activity with carboxynorspermidine in vitro [3].,384,1.0,-0.032304846,-0.022270966,-0.06839967,-0.06874933,0.06427883,0.035991684,-0.046806443,0.014100013,0.06975894,0.065278135,-0.014750376,-0.021048553,-0.027353479,0.1364369,-0.009002668,-0.019327195,-0.06530446,-0.026595084,0.015282007,-0.001080552,0.09692026,0.05417204,0.018508978,-0.05616398,-0.016812209,0.027752861,0.08652912,0.002692661,-0.041286964,0.03465536,-0.049530786,0.020436302,-0.014933108,-0.12864828,0.07390099,0.055069335,-0.075375736,-0.03567918,0.113820106,0.05431875,0.046957355,-0.021078575,0.011773065,-0.05632101,-0.037345804,-0.016004432,0.09167584,0.049329903,0.093916304,-0.0925854,-0.12372791,-0.010766996,0.027481012,-0.044912636,0.044272386,0.0070776893,0.019278929,-0.07863387,-0.062309932,0.021807123,0.024475874,0.035047036,0.041907202,-0.019533334,-0.023778057,-0.054394603,0.0021064198,0.0054658484,0.0003874376,-0.012397117,-0.105281875,-0.015186609,0.057482492,0.032390356,-0.025050126,-0.006520834,0.035375327,0.014686785,0.014852016,-0.007894836,-0.021513063,-0.10305895,0.0738279,0.03518252,0.0062385537,0.023514016,0.074898325,0.028953034,0.06777163,0.034186788,0.009715302,-0.029735122,-0.00046189403,-0.07774249,-0.054361675,-0.052014444,-0.024246454,-0.01917929,0.012967551,-0.0473106,-0.041946962,-0.04308069,0.00415063,-0.08757468,-0.05559324,-0.013135678,0.012623987,0.09968618,0.05562578,0.009734143,-0.07603308,0.073325165,0.010055618,0.00568426,-0.039146446,0.055977706,-0.0075130383,-0.037484083,-0.0787973,0.0854509,0.054615583,-0.09677243,0.038637824,0.06673522,-0.025397956,-0.015424866,-0.022035249,4.9669544e-33,0.05785731,0.05880182,0.053642638,-0.016351184,0.057542548,0.08122676,-0.04107521,-0.05514105,-0.020206027,-0.1003715,-0.07049859,-0.099911064,0.041311365,0.051510297,-0.042925663,-0.009460543,-0.14334416,-0.025941383,0.040184468,-0.015071549,0.0740668,0.06273987,-0.017686233,0.041256268,-0.025047464,0.02793462,-0.021271627,0.00071884034,0.031325087,-0.0049495846,0.026783992,-0.031232473,-0.10192323,-0.04069299,0.08259549,0.015459394,-0.1050358,-0.023510614,-0.06969824,0.020451637,-0.021598693,0.023964118,-0.04044933,0.0334113,-0.01766367,-0.09362658,-0.07005095,0.12689589,0.055902928,0.066809945,0.020501701,0.013814875,0.051902346,-0.040673018,-0.10636514,0.022863738,0.024213463,-0.041761495,0.0131450435,0.004765612,0.040013038,-1.20715795e-05,-0.05163758,0.02576405,-0.036257695,0.02157773,0.069667324,-0.088346764,0.099144205,0.05295061,-0.027607426,0.0022684545,0.016500419,0.053426348,-0.02419915,-0.018370725,-0.07102717,-0.030186692,0.020464724,-0.007190431,-0.024317637,-0.05489854,-0.00051415164,-0.024828315,-0.04970747,0.01828752,-0.009681063,-0.015134496,0.035621945,0.012523791,0.05091835,-0.12384939,-0.0016952276,-0.0010016286,0.0081869215,-6.0799514e-33,0.040661037,-0.058125805,0.08249882,-0.040819652,0.0011916495,0.0045977286,0.06621406,-0.02500984,-0.009374595,-0.023090977,-0.0023402984,0.017900165,0.0657797,0.038393866,-0.01682912,0.06229477,0.024121972,0.02487359,0.03282946,-0.011002458,0.048129298,0.02562938,0.052850753,-0.013662519,0.047132246,0.015453777,0.0021739176,0.05567553,-0.044229925,-0.0040712175,0.0076017394,0.043648396,-0.050820842,-0.06748215,0.0020223553,0.015856324,-0.061653577,-0.021627093,0.062002238,-0.013846719,0.032121975,0.052816216,0.002245868,0.06696833,-0.06041766,0.059352424,-0.067836165,0.016325267,-0.0075483727,-0.018827304,-0.05943826,0.03394735,-0.034978453,-0.05152166,0.037292484,0.0021442196,0.005201227,-0.016574046,-0.014977692,0.03727498,-0.03093785,0.0107521145,0.017481886,0.046287373,0.0358834,0.006605356,0.060348324,0.12565163,0.062811546,-0.06294913,0.103765495,0.01898349,0.080870755,0.09112327,-0.055024724,-0.04567728,-0.06551749,0.017876673,0.016876139,0.02989476,0.037535932,-0.021184107,-0.020694613,-0.0693373,-0.023105523,-0.043642875,0.117695406,0.07380245,0.050157297,0.00091117655,0.009346538,-0.03286624,0.031469047,0.059704687,0.07164312,-4.043175e-08,0.02785347,-0.10295596,0.033096243,-0.031919252,0.00820217,-0.017508423,-0.026732288,0.014719944,0.06855942,-0.026601622,0.02546345,0.0034848526,-0.004840887,0.02850877,0.022658631,0.05237237,-0.05082863,0.013594188,-0.0427026,-0.040223457,-0.05872874,-0.01813167,-0.12312495,0.03770505,0.07481359,-0.010020037,-0.06598584,-0.015017201,-0.072989434,-0.06413483,-0.017560795,0.01570401,-0.04032265,-0.03632526,-0.14811967,0.06767172,-0.044553325,-0.023089573,-0.042167697,-0.027281988,0.042009205,-0.09121301,-0.01600848,-0.005242575,0.043661434,0.04368206,-0.069128625,-0.039575845,-0.020705638,-0.07452227,0.029369798,0.014840803,-0.005142545,-0.0013348474,-0.10011303,0.026976574,-0.017062178,0.0011078053,0.01646318,-0.08827815,-0.024828767,0.044550005,0.14555985,-0.06692755 +4.2.3.131,"Isolated from the plants Rosmarinus officinalis (rosemary) and Salvia miltiorrhiza. The enzyme from the plant Selaginella moellendorffii is mutifunctional and also catalyses EC 5.5.1.12, copalyl diphosphate synthase [2].",384,1.0,-0.06925234,-0.04500192,-0.12921424,0.045338623,0.11153682,0.10184398,-0.102002844,-0.013041825,0.058002293,-0.10070888,0.027288297,-0.02100042,-0.05364481,-0.08547202,-0.08588533,0.043937903,-0.027624866,0.04241517,-0.045460876,-0.027590534,0.07836658,0.011342563,0.03353362,0.03785732,0.06912226,0.028578673,0.015586669,0.020375727,-0.026527135,-0.09182874,0.07499371,-0.0044087735,0.03209254,-0.10877702,0.07818536,0.04338523,-0.040718134,-0.07329002,0.059003234,0.03906386,0.009785483,-0.06555577,-0.022617843,-0.073304296,-0.055007137,-0.071956486,0.013899814,0.0049867644,0.04828639,-0.06990484,-0.0771412,-0.06676378,-0.0660003,-0.0055556316,-0.021508487,-0.018230274,-0.01709076,-0.021245873,-0.017004091,0.035855018,0.066515766,0.037993252,-0.027891522,-0.067325495,-0.06658961,0.008828629,-0.045974206,-0.059883893,0.095773056,-0.040535472,-0.07075949,-0.06844289,-0.010650525,0.047095004,-0.011708985,0.030054914,-0.012091358,-0.04239455,0.06209471,-0.0031153387,-0.016058985,-0.0039464957,0.008122826,0.008198748,0.03363566,0.026501743,0.047782738,0.083693095,0.090978,0.017043352,0.010646438,0.021250274,0.0052324915,-0.05968958,-0.022823744,0.058187343,-0.055534743,0.025603795,-0.00471881,0.012914833,0.010844216,0.05485772,-0.04317798,-0.11875539,-0.051188704,0.050535884,-0.011025766,0.02558005,0.005822353,-0.08094014,-0.026742138,-0.013220599,-0.03421815,-0.031951543,0.0137942135,0.033923756,0.047490112,-0.07061541,-0.043158513,-0.04001424,0.035754777,-0.03523253,0.0262914,0.058128927,0.024881788,0.06964237,-0.122045405,5.2609654e-33,0.05967788,0.007633439,0.007904089,0.022714103,-0.06364719,-0.021087484,-0.0642674,0.08302078,-0.07329337,-0.04290202,-0.054370087,-0.0683706,0.0019666778,-0.01368475,0.05655431,-0.059856296,0.08319837,-0.041647177,0.053861145,-0.016382396,0.019578766,0.063136436,-0.04676747,-0.0007311585,-0.02825296,0.0095248,0.0021429933,-0.02349859,0.10321613,-0.0049954206,0.103608765,-0.08455151,-0.06790012,0.0088530285,0.052343465,0.021138068,-0.054779675,-0.01671107,-0.014561532,0.06896224,-0.016573967,0.056366693,0.04585068,0.013223675,0.071650304,0.010559351,-0.048420116,0.043847892,0.16610874,-0.022109536,-0.018153038,-0.0011127945,0.12661812,0.012639102,-0.007148447,-0.007364656,-0.03965757,0.06673087,0.049456023,0.08113745,-0.04522454,0.01423783,-0.017203854,-0.039973605,0.045464553,0.059427977,-0.017126115,0.015126523,-0.0052833054,0.03737964,-0.009291526,0.0046692616,-0.010031258,0.0137132425,0.015316567,-0.023622412,0.0022924843,-0.011098447,-0.017480435,0.027411826,-0.008937604,0.0125078,0.029472275,0.045397837,-0.05780464,-0.0420259,-0.08339808,0.023146043,0.0064166095,0.10315273,0.023566304,-0.039869707,-0.03245226,0.030060707,-0.030401008,-3.8870527e-33,0.07381761,-0.083115466,-0.017723115,-0.08506843,-0.12987071,0.11985588,-0.008087858,0.02924945,-0.048394155,0.042711932,0.012408049,0.0017357961,0.085497014,-0.069963366,-0.053761993,-0.002937281,0.042531244,0.08832502,0.028723324,0.031214697,-0.06755206,0.104755014,0.07184366,-0.004368928,0.060902856,0.04581942,0.07462074,0.014155383,-0.059032295,0.016963381,0.022179475,-0.027680526,-0.052700337,-0.07511008,-0.10900904,0.06442426,-0.04693122,-0.041445225,-0.016873764,0.048326373,-0.0250422,0.042234596,-0.0012395157,0.03817523,0.05498425,-0.014884525,-0.08377012,0.045624834,-0.060044017,0.0072995354,0.02764802,-0.0151660945,0.029892858,-0.04617619,0.027233804,-0.01702279,0.027694164,-0.0062419265,0.02317901,-0.011810245,0.040333215,0.016309831,-0.0435951,0.024249977,0.076251745,0.11709204,-0.0001226196,0.05863012,-0.030830309,0.0047176336,0.031663902,-0.0048788665,0.031391315,0.08164888,0.019706259,0.0552314,0.015757315,-0.004166655,-0.024244474,-0.0004351881,0.045163274,-0.06878878,-0.0032079306,-0.09227858,-0.050686568,-0.057684075,0.05557504,0.053269185,0.056032788,0.025211498,0.012101522,0.026337394,-0.019085491,0.06570108,0.12232412,-3.4241257e-08,0.042571638,-0.046133712,0.047754843,-0.032334294,0.013782308,0.009096467,0.027963985,-0.059912786,0.026175972,0.06451812,-0.082687646,0.0041911453,0.046219084,-0.03261991,0.01520465,-0.009035244,0.041891463,0.060027122,0.00017463203,0.023891617,0.018494667,0.048306283,-0.10539795,0.03090031,0.028705971,-0.14437993,0.046204478,0.0035115588,0.026252802,0.013691432,0.05472549,6.4924745e-05,0.031968024,-0.043051355,-0.025326693,0.051991474,-0.041881762,-0.046891555,-0.044466745,-0.010027366,-0.041907243,-0.075091906,-0.001226348,-0.03112916,-0.03676248,-0.0062575177,0.01547317,-0.0152419275,0.024958355,-0.0133187575,0.06443199,-0.036992412,0.04047437,-0.046991006,-0.08319343,-0.038670767,0.024920907,-0.07156053,-0.0067979433,-0.088976696,-0.054766692,0.027194258,0.080356926,0.026249899 +4.2.3.132,"Isolated from Abies grandis (grand fir) [1]. This class I enzyme forms about equal proportions of abietadiene, levopimaradiene and neoabietadiene. See also EC 4.2.3.18, abieta-7,13-diene synthase and EC 4.2.3.32, levopimaradiene synthase. An X-ray study of this multifunctional enzyme showed that the class I activity is in the alpha domain, while (+)-copalyl diphosphate synthase activity (EC 5.5.1.12, a class II activity) is in the beta and gamma domains [2]. In Pinus taeda (loblolly pine) the major product is levopimaradiene, with less abietadiene and neoabietadiene [3].",384,1.0,-0.022485701,-0.12072066,-0.022167694,-0.039219767,0.022383114,-0.019519072,0.022388892,0.010344111,0.014157091,0.018793885,0.009573829,0.011660217,0.016607065,-0.019910824,-0.055895247,0.054431003,-0.0759754,-0.08741368,-0.04216619,0.030289238,0.12207109,0.04273822,0.0062959143,0.07334001,-0.00969234,-0.076210916,-0.004635157,-0.03241931,0.015904533,-0.09101515,-0.0390431,0.034391776,0.015453659,0.037014667,-0.02036977,0.03039084,-0.03150145,-0.09254457,-0.0021610241,0.063046664,0.08917812,0.009684342,-0.025993025,-0.10242445,-0.04943735,0.022592735,-0.016272485,-0.09510405,0.04298071,0.00070158043,-0.008462886,-0.099761225,-0.05299707,0.072541624,-0.008312221,-0.037145887,-0.00624883,-0.02554866,0.0006576373,0.08827251,-0.0049391855,0.07202507,0.007989166,-0.061599135,0.03058434,0.015873076,-0.056061365,-0.020416198,-0.045219,-0.06633782,-0.022122758,-0.07921911,-0.097325146,-0.0010518671,-0.013712078,0.03688327,-0.024450533,0.0023616652,0.014055532,-0.106698506,-0.030317966,-0.011918652,0.026811494,0.057078917,-0.01272589,0.05575305,0.051149245,0.06034024,0.03476638,-0.039493162,0.066887215,-0.0011385501,-0.059786744,-0.010253778,0.0044391323,0.06269353,0.067584224,-0.060275912,-0.0068188296,-0.008334272,-0.034152802,-0.041534793,0.0024933764,-0.096489474,-0.12290737,-0.0022385349,0.018122891,0.043554883,0.058598723,0.01309788,-0.013565991,-0.045562744,0.019007808,0.05269907,-0.056927077,0.062109236,0.015059276,-0.034382537,-0.054669987,-0.04210791,0.021470403,0.028830199,0.09185585,0.10314209,0.00071319245,0.06782759,-0.101283625,3.2262603e-33,0.07966605,0.061405484,-0.021356238,-0.011090976,-0.045270573,0.037362643,-0.09681687,-0.010463118,-0.054823343,0.0038154677,-0.059006017,-0.0130231045,0.04329773,0.006521263,0.03921551,0.039642006,0.023349699,-0.004627611,0.03556996,-0.002058963,-0.036226913,0.07528933,-0.05361169,0.009141082,0.021428214,0.06943365,-0.027805427,-0.009458898,0.035742424,-0.0069967643,0.061369766,-0.07547277,-0.106852666,0.046729997,0.051975936,0.00034270968,-0.0020033214,-0.060744997,-0.057574995,0.009506988,0.036701247,-0.01608496,0.04321215,-0.03434138,0.0853601,-0.046485685,-0.00805091,0.042841602,0.048817094,0.009336802,-0.0015405308,0.0014659018,0.07755543,-0.044962976,-0.110143594,0.059457105,-0.009197635,0.028145267,0.05491797,0.122065544,0.05638481,-0.00507046,-0.003074447,-0.019869916,-0.044205345,0.04063015,-0.12851366,-0.053284798,0.0045790304,0.016187232,0.0031632767,-0.09873094,0.03369451,0.028085496,0.06891254,-0.0016010473,0.019799918,0.059057645,-0.03192971,0.050712112,-0.0494403,-0.0013125631,-0.00638563,0.0055816527,-0.06277854,-0.037812103,0.056428593,0.034687385,0.008596795,0.06877711,0.06537983,0.018407186,-0.035568777,0.0054885102,-0.0077555412,-3.8340974e-33,0.039380502,-0.10561551,0.045647454,-0.12049554,-0.0752723,0.05413903,0.007647788,-0.04978223,0.01980449,-0.015593421,0.10729838,0.08109636,-0.016864555,-0.08937982,-0.012100462,-0.0008172494,-0.0058973692,0.14062035,-0.0042231414,-0.03635925,-0.0034678646,0.10198413,0.0077906847,0.0071270973,-0.007586812,-0.0005751463,0.02083127,0.07695858,0.04858906,0.016558807,-0.0011726833,0.026295254,-0.07366863,-0.073743954,-0.05052975,0.014633447,-0.017333612,-0.04228297,-0.030075975,0.008962399,-0.067982234,0.028445574,0.04163342,0.033340205,0.1292758,0.03262933,-0.06466299,0.028541805,-0.016677223,0.07321592,0.03901474,-0.04952358,0.06673,-0.041969486,0.017144319,-0.0369802,0.022616832,0.03881144,-0.038679224,-0.094112396,0.03911389,-0.019389149,0.027502695,0.007921452,-0.0079396935,0.070635445,-0.0077177957,0.022827974,0.056780573,-0.011801295,0.043983545,-0.025318738,0.0022017274,0.026638744,-0.0032157307,0.06590023,-0.007168172,-0.026029712,-0.0072428226,-0.065281935,-0.020402053,0.07448734,-0.053367253,-0.009895626,-0.037132554,0.029207883,0.06099668,0.111715786,0.06390638,-0.09050546,-0.0689991,0.028129632,-0.016601749,0.05239467,0.03836549,-4.771666e-08,-0.0012110076,-0.0058054593,-0.012653659,-0.02477824,0.03885215,-0.020305978,-0.060616616,-0.008069939,0.03708562,0.005640498,-0.07118073,0.073657826,0.0077294647,-0.006409108,0.043286927,-0.0038182496,0.04686429,0.05005361,-0.0051080314,0.055114713,0.017537525,-0.035728898,-0.061630074,0.04447022,-0.029299388,-0.15937658,0.06378168,0.038582187,-0.004614563,0.017539807,0.05802577,0.068600066,-0.011172924,-0.048183173,-0.01773603,0.019505264,-0.024397185,0.056156732,-0.022656925,0.05884304,-0.003484147,-0.14746004,0.025280733,-0.07021747,-0.004949013,-0.02825637,0.026735347,-0.017812438,0.10946283,0.03671489,0.015809998,-0.0030552058,0.003576151,-0.030073348,-0.06560986,-0.047616865,-0.027367638,-0.1259364,0.0910371,-0.09906915,0.02161021,-0.006495434,0.09776872,-0.003238152 +4.2.3.133,"Isolated from Helianthus annuus (sunflower). The enzyme also produces beta-caryophyllene, delta-cadinene and traces of other sesquiterpenoids. See EC 4.2.3.13 (+)-delta-cadinene synthase, EC 4.2.3.57 (-)-beta-caryophyllene synthase.",384,1.0,-0.040840015,0.008438519,-0.11010537,0.009654272,0.024636382,0.08043399,-0.029257026,-0.0025928007,0.03171678,-0.035953786,0.061478868,-0.069721565,-0.074782126,-0.06568058,-0.031573445,-0.02802045,0.024198184,0.009921421,0.0049825776,-0.02944935,-0.0016021101,0.045119107,-0.020038579,0.03821604,0.07780006,-0.015437295,-0.024500757,-0.062129837,0.001570692,-0.12080141,-0.028096747,-0.004324696,0.026501263,-0.06545714,0.0965752,0.0048486823,-0.0014132255,-0.055130225,0.06930159,0.011720796,0.07241834,-0.016088953,0.027814535,-0.076632075,-0.093120694,0.009997469,-0.055825215,0.021433355,0.03547447,-0.07439878,-0.028971486,-0.027288476,-0.037189994,-0.034846712,-0.019417718,-0.058357492,0.07528265,0.014567669,-0.055993076,0.057455648,0.058347154,0.013920848,0.008384387,0.007381267,-0.077943444,0.001944469,-0.013682248,-0.009288097,0.09361161,-0.045957588,-0.074489266,-0.05665869,-0.06348482,0.04223149,-0.0029101523,0.07111372,0.0202578,-0.00028025996,0.08246683,-0.04921642,-0.0023952492,0.026514508,-0.029829282,0.07147322,0.00027323255,0.058027603,-0.053201795,0.10351842,0.06673648,0.018394202,-0.006133439,0.02953284,-0.042405576,-0.069672115,-0.07988307,0.027181026,-0.0009101049,-0.009327364,0.0015164714,-0.018161727,0.05484685,0.02821166,-0.028784584,-0.104102075,-0.083427764,0.10853469,-0.054146376,-0.08230479,0.10755144,-0.01623691,-0.014901144,0.034663532,-0.033141863,-0.042245116,-0.04361481,0.00917305,0.0059088366,-0.047682285,0.0038428819,-0.009618408,-0.014417064,-0.08189562,0.074842386,0.032875936,-0.006647227,0.032385077,-0.09528114,-1.0278409e-34,0.095511094,0.1120783,0.051234,-0.008121908,-0.03940816,-0.005670711,-0.040272877,0.06422569,-0.11230741,-0.10000959,-0.097468086,-0.067140944,0.010270412,0.02579059,0.02525037,-0.028905572,0.003921233,0.008167124,0.0691656,-0.05679187,-0.027101107,0.07385975,-0.074165,-0.0041057444,0.05685456,-0.0458968,0.010077452,0.0016095766,0.02314496,0.005392164,0.04294119,-0.0428352,-0.014686825,0.016409753,0.08536668,-0.02445377,-0.04499179,-0.077163994,-0.039281704,0.0927386,0.056794543,0.096282944,0.10001747,0.004122959,0.018786466,-0.004443297,-0.038728658,0.02779109,0.1414767,-0.01357276,-0.04867513,0.035581928,0.124444015,-0.043895096,-0.03961519,0.009590838,-0.011866,0.018357977,0.065207034,0.06594333,-0.026041048,0.09761386,-0.07054743,-0.06150541,0.047408167,0.10599435,-0.1095632,0.03031857,-0.06871406,-0.0121540595,-0.022126464,-0.06515487,0.01619488,-0.063864425,0.08554528,0.043412324,-0.020441512,0.01999794,0.04041539,-0.04892483,-0.009977308,-0.010517631,0.022918247,-0.07496644,-0.022451792,-0.032382663,0.0056344,0.07150161,-0.019124554,0.023400724,0.09458568,-0.01399669,-0.0364572,0.020594107,-0.022995368,-9.9693795e-34,-0.037448157,0.009734164,-0.02132711,-0.088416606,0.003420531,0.0096550705,0.008673392,-0.021352636,0.043506015,-0.0049678925,0.029897051,-0.02400367,0.123083085,-0.072200686,-0.04484715,-0.023717077,0.041535936,0.11774456,-0.018728228,0.006601974,-0.07367993,0.012990025,0.04243122,0.054581665,-0.009479472,-0.010718933,0.017133528,0.04766188,0.024316985,0.0046450337,0.09592246,0.0020040888,-0.0456126,-3.2456086e-05,-0.074714154,-0.019839693,-0.07446632,-0.0030942776,0.06639788,0.0383034,-0.054767486,0.001300533,0.016026638,0.042675722,0.08761765,0.027734313,-0.0951027,0.07971987,-0.07342388,0.08777117,-0.018308992,0.022040505,0.01842673,0.0069403425,-0.012687058,-0.030299097,0.035061117,0.055686332,-0.010735158,-0.048849523,0.028137317,0.008310821,0.008366192,0.050905712,0.063569754,0.07297955,-0.011749993,0.01601509,-0.043453224,0.0038879781,0.044854656,0.02002127,-0.021642013,0.01753997,0.010379929,0.04519036,-0.01862035,-0.111308366,-0.009389326,-0.002475598,-0.0089046415,-0.0023141538,0.043089774,-0.045767557,-0.043133058,-0.044750087,0.006752492,0.021349112,0.07000343,0.060099296,-0.023329515,0.050748378,-0.050374255,0.055652425,0.11611779,-3.4309302e-08,0.0705204,-0.028150985,0.04417982,-0.00912637,-0.00981034,-0.031239018,0.021959286,-0.033816207,0.074010976,0.024537671,-0.0586058,0.01312892,0.02407362,-0.047612164,0.06828129,-0.051868215,0.068506055,0.033752277,-0.011191825,0.016387558,-0.0048391474,0.002127409,-0.003458199,-0.03288699,-0.018171938,-0.0852463,0.014297503,-0.028018985,0.06527079,-0.0167971,0.013768204,0.04084443,-0.03168081,-0.05284417,-0.080370136,0.039562773,-0.015283125,0.03695731,0.0045186966,0.021163436,0.0076883547,-0.08579763,-0.03160325,0.021475844,0.020800035,0.025395993,0.034021538,-0.0036191943,0.0048553315,-0.034575917,0.0045036552,-0.024704179,0.0010661471,-0.100710414,-0.06139718,-0.053503864,-0.050106347,0.0022489193,0.0008410772,-0.061238803,-0.07679419,-0.026841536,0.1851239,0.056681402 +4.3.2.6,"The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the terminal gamma-L-glutamate of the side chain, releasing it as the cyclic 5-oxo-L-proline.",384,1.0,-0.08542569,-0.007681412,-0.09808472,-0.012832073,0.04512106,0.062281884,-0.10187423,0.024821488,0.046845026,0.026831312,0.030016316,0.025296006,0.06682836,0.048818976,-0.046572886,0.065815076,-0.09559553,0.004167942,-0.025872372,-0.049730234,0.094100185,0.048747983,-0.013353494,-0.03198794,0.038387343,0.039853975,0.04915589,-0.0021230704,0.03218319,-0.069027394,-0.0028046067,-0.04868245,0.031904604,-0.08269126,0.046054102,0.04341185,-0.02660172,-0.014296352,0.16216421,0.014978662,-0.0810032,0.026734972,-0.056196775,-0.048952688,-0.028205192,-0.08966435,0.021416955,0.061775304,0.04069917,-0.00027104685,-0.032719392,0.0075943917,-0.06945085,0.03109617,0.03323605,0.055808816,-0.080351815,-0.0631281,-0.045327146,-0.0003263254,0.04948662,0.0061943377,-0.008678313,0.022831902,-0.053593706,-0.01825034,-0.008885286,-0.057973195,0.021944076,-0.06657286,-0.105807446,-0.09516717,0.012300615,0.033141773,0.0325755,-0.048717022,0.008517867,0.013616548,-0.0382479,-0.07638665,0.07716964,-0.02643857,0.000977857,0.113863826,0.071461685,-0.009193328,0.04418578,0.027583035,0.08201393,0.019501848,0.014890468,-0.05582578,-0.016638452,-0.036105525,-0.043950163,-0.042205498,-0.02530175,0.034578815,0.03233004,-0.002175665,0.024710722,0.0579789,-0.00399665,-0.10638775,-0.035684414,-0.009325892,0.016126735,0.08603979,0.060359832,-0.026249964,-0.0063290843,0.0048374003,-0.0018735336,0.022822719,-0.027568266,0.051096443,0.07549128,-0.014310385,-0.10122808,0.012585486,0.05149568,0.018321117,-0.018564401,0.081627995,-0.048691936,0.038124006,-0.05649298,1.2075551e-33,0.019509267,0.09546682,-0.028006801,-0.031473268,-0.004234615,0.013246055,-0.026070585,-0.0017471932,-0.018745381,0.0036097432,-0.08002518,-0.0929602,-0.011272952,-0.0032343313,0.0125358645,-0.100069515,0.011766184,-0.008167494,0.0072789704,0.04113166,-0.008649953,0.08026153,-0.05072678,0.012907602,0.05078753,0.10309381,0.008718037,0.06993548,0.0804224,-0.0023803147,-0.025669772,-0.06559201,-0.117689826,-0.03502513,0.07554459,-0.037745874,0.004544003,-0.014051922,0.0404286,0.03605031,-0.010551223,0.021995112,-0.109291025,-0.015166768,0.04355295,-0.020128775,-0.031855676,0.13570586,0.048901457,0.022024019,0.035276745,-0.0736907,0.09729023,0.002705927,-0.07354707,0.051533364,-0.04789849,-0.013544625,0.010679686,0.07436502,0.034800258,-0.0325974,-0.0022886882,0.03259788,-0.014050597,-0.040207382,-0.0496785,-0.02189919,-0.03005089,0.080212474,-0.092961475,0.03032544,0.039140604,0.034711488,-0.016215311,-0.017230336,-0.09091087,0.0016873375,0.12896803,-0.027089644,-0.0098057445,0.021017915,-0.029152544,-0.027966147,0.02626743,0.035623394,-0.014104198,-0.09226815,-0.03541928,0.09151699,-0.00097513036,-0.08172465,-0.00925336,0.05612743,0.047667578,-3.043627e-33,0.10718085,-0.09186186,0.03295001,-0.06997771,-0.05838175,0.04927987,0.021240186,-0.05861427,-0.00265299,-0.00044867257,0.00020412635,0.023579706,-0.005461399,-0.045922298,0.021597305,-0.000291212,0.07611962,0.08912287,-0.018023739,-0.0023180924,0.037015557,0.01838956,0.0050206315,0.00039873493,0.010275643,0.07766518,0.026185496,0.07819998,0.05886753,0.097574644,0.03340355,-0.06397977,-0.060312122,-0.11731996,-0.049652398,0.14638895,-0.039479665,-0.0055305534,-0.013836384,-0.019941691,-0.019104812,0.029187154,-0.0072805067,0.025617758,0.03452261,0.021724649,-0.071439944,-0.0036281263,-0.0059972466,-0.13271487,0.044182677,-0.015914954,0.032092806,-0.0082357805,-0.019182108,0.0045759575,6.747485e-05,-0.03538868,0.005756298,-0.041268874,-0.0501507,-0.042287134,-0.009785487,-0.005441712,0.007985864,0.012462702,-0.0032560779,-0.03133461,0.024038006,-0.033066183,0.022149833,-0.028442107,-0.036954112,0.052464176,-0.04079455,0.03121039,-0.048631337,-0.11967042,0.009717065,-0.038410515,-0.038953453,-0.052076783,-0.022887198,-0.039928522,-0.08637188,-0.102275476,0.046695367,0.08211914,0.05808187,0.04115738,-0.010953819,0.029828364,0.0030831902,0.02282785,0.041093666,-4.0134132e-08,0.029166903,-0.07621778,0.06478709,-0.014373625,-0.007931194,0.051816106,-0.030360607,-0.07750293,0.06782103,-0.06246949,0.015996864,0.06655789,0.020488912,0.038066927,-0.00660698,0.057659756,0.012133097,0.036461465,0.04056753,-0.017266411,-0.10834894,0.008337275,-0.071702786,-0.018237723,0.077973865,-0.087426014,0.026745364,0.0068703657,0.01934268,0.017271418,-0.016946603,0.018207096,-0.008783744,-0.01622855,-0.018613724,-0.0053118714,-0.004021763,0.011442373,0.065430194,0.008030317,0.07070991,0.012242244,-0.083305635,0.028145473,-0.010921625,0.024535809,-0.036455657,0.028169641,-0.08048545,0.026921146,0.029112045,-0.04827514,0.003882129,-0.05215012,-0.088473186,-0.001425406,-0.021801822,-0.05523445,-0.008313764,-0.04281124,-0.072814755,0.060246512,0.16421609,-0.03800637 +5.3.2.6,"Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enol form (2Z,4E)-2-hydroxyhexa-2,4-dienedioate is produced as part of this pathway and is converted to the keto form (3E)-2-oxohex-3-enedioate by the enzyme [6]. Another keto form, (4E)-2-oxohex-4-enedioate (4-oxalocrotonate), was originally thought to be produced by the enzyme [1,2] but later shown to be produced non-enzymically [5].",384,0.99999994,0.03099539,-0.05459736,-0.016275533,-0.018048855,0.03090805,-0.0097971475,-0.053432785,0.041159183,0.035719946,0.043165825,-0.01139402,-0.035000887,-0.113820955,-0.057762418,-0.017788677,0.087506585,-0.07603259,0.046837654,-0.04552383,-0.029593848,0.10375711,-0.045237765,0.020016186,0.05395846,0.024008278,0.04932735,0.043894712,-0.007155767,-0.049517136,-0.08951689,0.018204112,-0.0057161143,-0.020273004,-0.055940617,0.03207933,0.02558009,0.019969625,-0.10690652,0.045129627,-0.04323104,0.015713379,-0.0716003,-0.112353854,-0.031647455,-0.0001792233,-0.049820855,-0.019930545,0.00799584,0.04377874,-0.06551228,-0.06291904,-0.07034114,-0.024131866,0.012080785,-0.006572025,0.050998192,-0.036353283,0.045235086,-0.036845617,0.10407372,0.01662164,-0.008238248,-0.032469753,0.0321898,-0.025071876,0.0041598706,-0.003412395,-0.09139296,-0.0026875925,-0.005657255,-0.0678781,-0.09435653,0.021492291,-0.0050816354,0.01567813,0.10151923,0.022012789,0.018505912,-0.015275731,-0.048574377,0.08337045,0.051987454,0.06245802,0.009312828,0.04322332,-0.022063944,-0.0011061373,-0.057112955,0.09657097,0.063865155,0.006647139,0.016917735,0.02060289,-0.0027550254,-0.01722781,0.07099453,0.051827792,0.02463916,0.06514523,0.00090823084,0.004209358,0.013578773,-0.00735207,-0.073732615,-0.008642283,0.054249905,0.017674122,0.0863787,-0.010528421,0.008397884,-0.0233484,-0.07604013,0.045626592,-0.00025674806,-0.025709096,0.12689626,0.027329544,-0.026813608,-0.0104262065,-0.013479058,-0.025951302,-0.029014291,0.062346015,0.017017588,-0.07339996,0.02018746,-0.02774568,2.245982e-33,0.081604876,0.029167054,0.018432979,0.021773398,0.004192061,0.024852835,-0.074734956,0.03696173,-0.004210996,-0.09329111,-0.04729439,-0.079451665,0.03641488,-0.031083958,0.027930275,-0.056844413,-0.056637082,0.03957732,0.09556895,0.039324846,-0.024577426,-0.024210531,-0.08850685,0.015579726,-0.1069293,0.05999633,-0.046433292,-0.034301016,-0.027702857,-0.007369441,0.008305797,-0.05069035,-0.046299323,0.011577056,-0.060599305,-0.018868014,0.003890127,0.00032285467,0.007988431,0.082117446,0.073517345,-0.0036070582,0.009500011,-0.050201587,0.018703304,-0.031929012,-0.037030254,0.058336128,0.08758353,0.053822722,0.02890241,-0.06975314,0.08416216,0.010464443,-0.028166948,0.014348196,-0.0021230446,-0.012160885,0.07323906,-0.011824146,-0.02883686,0.10454008,0.034668084,0.037202407,-0.0089067165,-0.03223996,-0.04320112,-0.04137767,-0.085416846,0.022771368,-0.039847635,0.034052234,0.071044475,-0.03291364,0.06436677,-0.086796775,-0.08418265,0.03530786,-0.021360314,0.051767375,0.06976128,0.052856162,-0.01664079,0.03777362,-0.016242888,0.0052867746,-0.026874365,3.889521e-05,0.0005560461,0.09436055,0.003377134,-0.094836086,-0.057287224,0.015985971,0.01670425,-3.0067177e-33,0.0843076,0.0073830844,0.034131065,-0.046388473,-0.08094901,0.058465503,-0.0056925425,0.032364137,0.05270846,0.02096835,0.09236786,0.015263439,0.10691317,-0.08639845,-0.012869203,-0.085238755,-0.07684606,-0.02254158,-0.026450794,-0.042773385,0.051373754,0.036143135,-0.029091267,0.03771421,0.09113018,0.027376296,0.0058808452,0.048998218,0.06593575,0.005286518,0.045857828,0.010209698,-0.0100745205,0.0445721,0.03374393,0.04443927,-0.059230056,0.0010976242,0.03982922,0.013062595,-0.10284401,0.036636848,0.045402646,0.017835155,0.036337946,0.031972248,-0.04163105,-0.022180999,0.049204927,-0.06807449,0.006687226,0.051639054,-0.16087344,0.03383342,-0.0065331133,0.059297904,-0.03973365,-0.032809533,-0.022399904,-0.016181268,-0.040359218,-0.061677653,0.104352966,-0.028468968,0.048195127,0.013789372,-0.048734978,0.10011281,0.0059767193,-0.019829383,0.08275495,-0.027461056,-0.013438323,0.05632765,0.01934025,-0.04039988,-0.04768567,-0.04130144,-0.047322016,-0.048336845,-0.012184417,-0.038745586,-0.010673897,-0.10821734,-0.05699445,-0.10530051,0.017089786,0.06959466,-0.038542766,0.042154822,0.057263948,-0.046827003,-0.04888102,0.11102325,0.05649609,-4.566948e-08,0.027503874,-0.09842317,0.0041487445,0.03840458,-0.0003711683,0.02613776,0.04420367,0.03374159,0.10387268,-0.110235274,-0.04257085,0.01414321,0.0043890765,0.07462294,0.03482287,0.0045308718,-0.03128028,0.019039769,-0.01809826,-0.0015623423,-0.05912001,-0.09656022,-0.071264,-0.045454167,0.05209648,-0.050521664,0.0104969,0.026815806,-0.011871721,0.012345547,-0.0060827727,0.026687365,0.058545068,0.039893515,-0.034547523,-0.024545318,-0.078816764,0.0012882719,-0.123576,0.050124284,-0.058040533,-0.07271514,-0.035611138,0.025897192,0.017893916,0.036335148,0.015254254,0.052226845,0.02002307,-0.006689336,0.00056893774,-0.025622752,0.015537095,-0.07468984,-0.0962469,0.034117177,0.030798769,0.031147951,0.0012042178,-0.08788266,-0.025549442,0.03780477,0.17791094,0.050139245 +5.4.3.9,"This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster, which is coordinated by 3 cysteines and binds an exchangeable S-adenosyl-L-methionine molecule. During the reaction cycle, the AdoMet forms a 5'-deoxyadenosyl radical, which is regenerated at the end of the reaction.",384,1.0,-0.059863236,-0.07877619,-0.111530714,0.052448053,0.09502394,0.016957836,-0.05321591,0.0029090901,0.008439758,0.0015768016,0.05079161,0.07449037,-0.05560019,0.043343652,-0.02134099,0.11140011,-0.11552922,0.036712278,0.01042928,-0.049894053,0.019934658,0.0099268155,0.013696795,-0.037105482,0.056769714,0.054190006,0.09259386,-0.025953354,-0.050413746,-0.061124414,0.058548912,-0.033054933,0.06405535,-0.009028836,-0.01230925,0.1337271,-0.045153517,-0.021912917,0.0520243,0.012325565,0.020786548,0.007543119,0.0055092243,-0.03379524,-0.009750247,-0.04175268,-0.040639598,0.02265328,0.06555479,-0.011545323,-0.06192395,-0.013039862,-0.020552373,0.004423097,0.014855994,0.047192533,0.021465957,-0.002284342,-0.02842149,0.011461994,0.12500304,-0.037987966,-0.07089534,-0.023048839,-0.01940504,0.019397194,0.081055224,-0.06322046,0.04348957,-0.06353094,-0.028216286,-0.0065749795,-0.0017820457,-0.012786184,-0.047717758,0.03580627,-0.038826432,-0.06476123,0.04185206,0.023497686,0.05231621,-0.0025645755,0.031803686,0.047964577,0.09003696,0.044440728,-0.016740879,-0.021814039,0.025158068,0.010550708,-0.06839526,-0.0034025225,-0.07753701,-0.058624666,-0.03150682,0.00647254,0.022929229,0.029697288,-0.05717821,0.0025619506,-0.03257894,0.08518792,-0.06280789,-0.072699405,-0.077320084,-0.018329969,-0.02058199,0.06263434,-0.0083091,0.04126496,0.0059033437,0.05701715,0.046457402,-0.001870687,-0.012794584,0.077241294,-0.011450552,-0.026418341,-0.043084826,0.043851305,0.037292063,0.048270054,0.017559139,0.05759111,-0.0014095334,0.01474871,-0.103956975,-6.474373e-35,0.09117284,0.097091965,0.05273583,0.016964424,-0.0060211355,-0.0031774624,-0.119347505,-0.022361727,-0.040545218,-0.0109573705,-0.05422207,-0.05407702,0.08960987,-0.038329486,-0.09962194,-0.09053122,-0.05536991,0.007287589,0.07459718,-0.024717413,-0.060957998,0.060937524,-0.14301461,0.058389734,-0.03962017,0.047339432,0.01716333,0.03469994,0.046080235,0.04470581,-0.08284567,-0.0057908376,-0.135789,-0.035495173,-0.0022202565,-0.034750134,-0.06825036,-0.1206231,0.04411229,0.020179195,0.015153169,-0.03416568,0.052161418,0.020348683,0.014872627,-0.043857448,-0.022777908,0.044107135,0.056401577,0.09194129,0.02304119,-0.04867407,0.08802373,0.017659524,-0.11304369,-0.039700422,-0.030161545,-0.03158322,0.031435385,0.10159369,0.042681016,-0.043973144,-0.063079014,0.030502109,-0.026691986,-0.0005372943,-0.009769781,-0.06177454,-0.008592105,0.10328455,0.041745935,0.03238505,0.113037094,0.05950482,-0.028291268,0.011361848,0.0588572,0.107028544,0.027378779,-0.0070291776,-0.08738015,-0.047818743,-0.013741871,-0.028945867,0.0077631194,-0.032228313,-0.0263757,-0.050527684,-0.030737814,-0.0018756555,0.0033969718,-0.060573917,-0.048055068,0.04230915,0.010718137,-1.0887462e-33,0.036500588,-0.0458958,0.0069694933,-0.066878244,-0.073823474,0.043957364,0.028370868,0.055159528,0.028569022,-0.01509394,0.07346605,-0.044936493,0.032093648,-0.0866864,0.06689326,0.036040533,0.019059679,0.015785335,0.019550122,0.014241415,0.06765413,0.08384278,0.0335877,0.030794783,0.109976575,-0.019693527,0.017821217,0.03094823,0.0390706,0.09028316,0.049199034,-0.031235933,-0.029108888,0.017872486,-0.012314628,0.06380605,-0.023438307,-0.010553688,-0.035126496,0.0295688,-0.014394522,0.02602728,0.006509344,0.15979746,0.04981348,0.059251852,-0.023871131,0.04425258,0.017525436,-0.115195476,0.015962658,-0.002631345,0.00717257,-0.04329986,-0.014861006,0.06497724,0.027305918,0.00022578456,-0.07809642,-0.031186903,-0.029006407,-0.05077779,0.056366876,0.019862639,0.015077329,0.020131096,0.024800822,-0.022679219,-0.0065810303,0.03326101,0.00046709127,0.012923421,0.007882661,0.09348774,-0.03948318,-0.021650784,-0.08175563,0.023726156,0.0078097438,-0.0022608968,0.0071797157,-0.00817799,-0.029995168,-0.08809014,-0.011540171,-0.07454033,0.047521576,0.10616497,0.02601678,-3.158286e-05,-0.06677195,0.04091555,-0.057738554,0.035541378,0.03579797,-3.8556372e-08,0.06610114,-0.059279706,0.027985059,-0.0562813,0.0019127524,0.03291043,0.032459084,0.009421876,-0.017948166,-0.025164183,-0.036465656,0.08594433,-0.04415789,0.009477794,0.0024466957,0.005750052,-0.037729435,0.018441062,-0.023383684,-0.018651314,-0.030132033,-0.01971539,-0.05098618,0.015320721,-0.039172783,0.018590495,0.07667176,0.019571569,0.00024806554,-0.031919725,0.081596285,-0.022205014,-0.0685201,0.004327937,-0.16802251,0.020553067,-0.036771737,-0.025653893,-0.005399652,0.082664035,-0.032411877,-0.081028454,-0.051099844,0.06608418,-0.06981851,0.03430213,-0.04431554,-0.031125069,0.0124585135,-0.0002735842,0.004149962,-0.014155316,-0.06768962,-0.041739114,-0.10625416,0.01312934,-0.023039753,-0.01742941,0.045198634,-0.06490374,-0.035602186,0.03866605,0.10280877,0.016464511 +6.2.1.39,"Catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. The enzyme adds one molecule of L-glutamate to a dedicated acyl-carrier protein, and following decarboxylation of the product by EC 4.1.1.95, L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, adds a second L-glutamate molecule. +Requires Mg2+ or Mn2+, and activity is enhanced in the presence of Mn2+.",384,0.99999994,-0.038745552,-0.0371383,-0.05882209,-0.019013524,0.04603574,0.039859615,-0.07571329,0.030223215,0.027249897,0.0004992743,0.050095864,0.00030733208,0.08362429,0.03127502,-0.01591085,0.020191342,-0.09084653,0.0047197123,-0.0479866,-0.032229967,0.10079407,0.041543238,-0.06726201,-0.07935069,0.058343228,0.062594,0.041418012,-0.03407679,0.0198102,-0.06649503,0.004008356,-0.05244917,0.050606687,-0.05043402,0.00995044,0.034142077,-0.047428012,-0.022389593,0.20175253,-0.010103979,-0.0943315,0.06703879,0.038616102,-0.072175145,-0.03406426,-0.10061099,0.06132658,0.017789334,-0.00091533316,0.019474098,0.045465264,0.059939172,-0.052009676,0.030770479,0.0033803263,0.02148878,-0.13882336,-0.027494004,-0.08803802,0.005758051,0.051803775,0.015081635,-0.0124784,-0.014503103,-0.04728326,-0.03897203,-0.0031734118,-0.032243986,0.06586132,-0.05102361,-0.02290184,-0.082746185,0.047206454,0.023410182,0.031069225,-0.0135625,0.04773594,0.03614635,-0.009528796,-0.044486716,0.045734826,-0.010793938,0.030508267,0.08327978,0.07770917,-0.033692777,0.018788595,0.05868603,0.041108064,0.035422843,0.1027057,-0.043249894,0.016780658,-0.00888969,-0.05537298,-0.0063257646,-0.029704917,0.038050182,-0.040652446,-0.02090018,-0.005544323,0.03460508,-0.0076750475,-0.110979326,0.005681183,-0.011023076,0.02421825,0.043995738,0.018654866,-0.024770059,-0.004698145,0.03548675,-0.008730055,0.046604823,-0.05365297,0.072587475,0.05714768,-0.056343555,-0.09529158,-0.0019252959,0.07647178,-0.014600797,-0.015189267,0.03733282,-0.03967385,0.011484131,-0.10064004,2.790155e-33,-0.016031474,0.04573573,-0.033147115,-0.024158197,0.042608898,0.011103575,-0.06367108,0.026123188,-0.031019446,0.0056007886,-0.10111141,-0.08492362,-0.031435493,0.036147058,-0.01971612,-0.10920206,-0.018559575,-0.027719619,0.06784534,0.019477768,-0.044933528,0.06425118,-0.075043365,0.03512028,0.031042906,0.09807736,0.056200556,-0.008599117,0.06972113,0.0042869644,-0.030758616,-0.101235196,-0.075213805,-0.023805365,0.04706991,-0.0053580236,-0.041974507,-0.034302283,0.037605207,0.023009099,-0.0011998318,0.042862546,-0.13478333,-0.018785255,0.038243234,-0.008694116,-0.05379163,0.07774174,-0.010651404,0.037679244,0.0319523,-0.04137677,0.0594821,0.0063901655,-0.054376036,0.025058182,-0.09921486,0.0046589044,0.07598179,0.09327048,0.030276315,-0.006099762,-0.0024552231,-0.00075235945,0.031752814,-0.03987918,-0.04612881,-0.056685153,-0.015256646,0.09746609,-0.059060253,-0.045946844,0.06494637,0.02415831,0.005527939,-0.01765548,-0.05509699,0.019649614,0.13942279,-0.02379655,-0.013202879,0.05203601,-0.0065385816,-0.024747176,-0.031124132,-0.018047215,-0.045693222,-0.07863979,-0.008630024,0.06256582,-0.044683825,-0.034258496,-0.019147094,0.048620503,0.022063268,-4.875277e-33,0.052962355,-0.10938464,0.041648455,-0.0776936,-0.06577182,0.063881844,0.039270233,-0.08332233,0.041674018,0.0026119554,0.033213623,0.0057957713,-0.0027036427,-0.061384246,0.020738352,0.01666596,0.056682978,0.07717309,0.01623797,-0.0056075263,0.018209172,0.05338422,0.027002538,0.017056372,0.002332574,0.06940054,0.012724348,0.07734019,0.06336437,0.09222031,0.038314715,-0.038631994,-0.024467431,-0.11012212,-0.059415393,0.105280995,-0.0074499743,0.0046613575,-0.018268526,-0.003922738,0.03383931,0.010677314,0.01317961,0.0658923,0.05258349,-0.05440095,-0.05607025,-0.029125284,0.026598485,-0.15725625,0.04137085,-0.0127751725,-0.012476649,-0.068798766,0.007679719,0.03583814,0.034200426,-0.0691683,0.06713008,-0.023719054,-0.0928471,-0.041762512,-0.013121691,-0.0468475,-0.015238282,0.017578693,0.018201172,-0.027078224,0.052129902,-0.024666315,0.053508528,-0.01720621,-0.00203323,0.025995243,-0.03529797,-0.0023547176,-0.047604058,-0.11000878,0.0229657,-0.049677983,-0.04973637,-0.035774987,-0.013827492,-0.029422987,-0.038911104,-0.12219596,0.01905102,0.12868007,0.043390315,0.042675406,-0.004170547,-0.026091283,-0.011128621,0.051110677,0.018291527,-4.5405304e-08,0.025212498,-0.10949623,0.045289714,0.0171678,-0.031250916,0.10672315,-0.049929302,-0.06854481,0.03291838,-0.06343459,0.062903516,0.0494601,-0.07151367,0.029092057,0.0048394226,0.06818608,-0.051151637,0.06292356,0.010576081,0.018660538,-0.065812826,0.019815251,-0.09057378,-0.001669551,0.05172038,-0.0017532719,0.026117267,0.01177779,0.012831616,0.02147339,-3.302534e-05,0.038390208,0.015110695,-0.002910789,-0.030193597,-0.09085066,0.010008816,-0.013986419,-0.0013062867,-0.004961453,0.029858032,0.017296348,-0.045658752,0.049783703,0.0012692808,-0.005162912,-0.008660084,0.017351456,-0.043725073,0.0067228526,0.064938255,-0.04491325,0.020003634,-0.026467202,-0.055221185,0.025976466,-0.057655323,-0.05710407,-0.01776352,-0.045834016,-0.06303022,0.037573203,0.14111617,-0.021394884 +6.3.2.38,"Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme is believed to form an adenylate intermediate prior to ligation.",384,0.99999994,-0.06994039,-0.046776205,-0.05803994,-0.0014840064,0.04857404,-0.04078487,0.022713792,-0.00083392207,0.038675237,-0.006494537,-0.040444184,-0.035435334,-0.057165228,0.008665611,-0.089855604,0.053586334,-0.048593238,-0.032499764,0.0021322437,-0.0042551546,0.02694895,0.054255597,-0.0388918,-0.006539648,-0.034618482,0.010420606,0.072304815,-0.000529565,0.0293714,-0.021560187,0.02723252,0.019741045,-0.022564178,-0.088158645,0.08599297,0.057341788,-0.005434888,-0.001164486,-0.0035826163,-0.019136008,0.052558962,0.02644825,0.05039043,-0.0013801089,-0.046942122,-0.019208923,0.014039118,0.025158864,0.03551899,-0.019604916,-0.06806973,-0.072188035,-0.04700864,0.028286636,0.07173939,0.010308885,-0.12228281,-0.04048806,-0.008154128,-0.0034169506,-0.01929288,0.030220687,0.016749451,-0.037167434,0.081622146,-0.013395765,0.023010835,-0.04845833,0.005992051,-0.0625154,-0.063896775,-0.10626246,-0.072376065,0.047897328,-0.026454145,0.032623913,0.029765395,0.0038927617,0.007856112,-0.04068025,0.024277246,0.020216107,0.09834957,0.089455046,0.06394862,-0.0008229299,0.033356454,0.058148798,0.0115894675,0.055740215,-0.008281139,-0.045558557,0.057463154,-0.034017317,-0.0061417567,-0.037693873,-0.075526595,0.028087033,0.021171665,0.024383988,-0.026221221,0.05483405,0.037945952,-0.049669378,-0.096156575,0.011170822,0.032438733,0.039298516,0.11872425,0.041782334,-0.002621895,0.036546327,-0.0016167816,0.026901701,0.0017071837,0.045516554,-0.0021456026,-0.0740158,-0.040923458,-0.028083028,0.0081191715,-0.032566775,0.021154696,0.037282854,-0.07683306,0.05601952,-0.14388601,2.1634487e-33,0.04056509,0.014768524,0.049947284,0.004552726,-0.035867542,0.05055101,-0.0907719,-0.034992784,0.019178905,-0.03754645,-0.10496127,-0.07754112,-0.006261554,-0.0047060545,0.040623695,-0.07217762,-0.058253285,0.0363827,0.032401167,0.0042230706,-0.047665827,0.110267684,-0.10058625,-0.01985026,0.04152201,0.11189154,-0.02050048,-0.085125275,0.09044325,-0.017291747,0.062261473,-0.076380186,-0.089496724,-0.00023623258,0.033876114,-0.000866303,0.03642936,-0.048395768,0.022167128,0.027334932,-0.06769811,-0.006272469,-0.037556343,-0.045182977,0.04436214,-0.044843014,-0.031789064,0.07048943,0.01001415,-0.011242294,0.022720026,0.0028233794,0.07933995,-0.04522282,-0.07263673,0.03811655,-0.027934637,-0.028866963,0.062150452,-0.007679636,0.005180531,-0.021150839,-0.019634597,0.023781426,-0.022545112,0.034588244,-0.053259,-0.10212708,0.0641986,0.066484205,-0.04728934,0.006049152,0.058882035,0.041046925,-0.011818684,-0.09435079,-0.067470476,0.020072456,0.07436584,0.09154029,0.03776775,0.05272293,-0.023774356,-0.05115273,-0.02457689,-0.08804976,-0.08182213,-0.009058693,-0.034171905,0.042991817,0.0024957333,-0.034447283,-0.08764194,0.039531346,0.032858606,-4.463107e-33,0.04499925,-0.099278055,-0.020366784,-0.063664794,-0.03853504,0.07849806,0.081735134,-0.041846078,0.010406047,-0.027254492,0.09362374,-0.015087695,-0.0046227667,-0.058719482,0.03387523,-0.042153183,-0.10701934,0.029372199,-0.0091046635,-0.057950765,0.029464787,0.04815336,0.058890495,0.019896733,-0.012090286,0.059311174,-0.038398854,0.10864171,0.08637189,0.071545854,-0.034291923,0.07857106,-0.05542117,-0.024235893,-0.03360393,0.061667114,-0.018009571,0.012870155,-0.030544579,-0.029081244,0.022561142,0.080661036,0.056211546,0.08034199,-0.0041023707,0.0950212,-0.03939693,0.044701282,0.052748043,-0.09529363,0.01602509,0.035761654,-0.03464538,0.024461139,0.06165648,0.034687493,0.061707687,-0.00815886,-0.051311158,-0.003923914,-0.08543168,-0.0623213,0.090523414,-0.017123548,-0.009196482,0.0589608,0.00497434,0.046389103,0.08561805,-0.017504586,0.053504456,0.0069712405,0.08753012,0.023761146,-0.030562446,-0.017209593,0.023575827,-0.05442399,0.049935117,-0.10799274,-0.03901744,0.057251956,0.00726575,-0.047141608,-0.023004495,-0.08083972,0.047096957,0.07970658,0.018480482,0.0074603152,-0.008068348,-0.014253048,-0.046885308,0.07177449,-0.04107376,-4.3765404e-08,-0.017816557,-0.10751631,0.079359494,-0.06428155,-0.019247875,0.07990692,-0.015297143,-0.04122011,0.03857241,-0.052933708,0.041651327,0.0021588504,-0.023211455,0.029377269,0.043851692,0.014972784,-0.00886142,-0.010885767,-0.03230098,-0.04394402,-0.060040087,-0.018431816,-0.09174086,0.053070437,-0.030062754,-0.0501777,-0.057275325,0.0377301,-0.027095295,0.045231745,-0.060597505,0.06935343,-0.004642594,-0.04691858,-0.09633411,0.0389093,-0.008233686,-0.016458686,-0.050805718,-0.09154976,-0.040124107,-0.017302332,-0.032413762,-0.020299248,0.058108997,-0.004309321,0.0074780276,0.026009422,-0.03308054,0.06063457,0.004703671,0.0049751936,0.06579146,-0.006314134,-0.09742167,0.049101498,-0.006279321,-0.112046264,0.033857934,-0.060196325,0.016126065,0.01058844,0.16465509,0.03860121 +6.3.2.39,"Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS). Type C enzymes are responsible for the formation of amide or ester bonds between a variety of substrates and a prochiral carboxyl group of a citrate molecule that is already linked to a different moiety at its other prochiral carboxyl group. The enzyme is believed to form an adenylate intermediate prior to ligation.",384,0.99999994,-0.08464138,-0.052317727,-0.07667081,0.0013724165,0.038321376,-0.026201215,-0.0083992705,0.0203354,0.052758355,-0.008632651,-0.021728106,-0.05841425,-0.056245565,-0.015077004,-0.08647366,0.033781543,-0.06736563,-0.0065106777,-0.009612018,-0.019900521,-0.020130692,0.037445303,-0.038364504,0.0018189363,-0.03130335,-0.014581836,0.067228585,0.005180926,0.009224755,-0.025538838,-0.0027915873,0.008688017,-0.022332475,-0.07179985,0.10210184,0.060085066,-0.02720792,-0.010462153,0.01823507,-0.04456658,0.04097639,0.02880473,0.045765236,0.02705147,-0.041815918,-0.029003168,0.0070094825,0.032778673,0.030013202,-0.016558582,-0.07675492,-0.069402084,-0.069739595,0.017981516,0.03292908,0.0174023,-0.12958036,-0.03896224,0.027699962,-2.223156e-05,-0.0055483757,0.02581359,0.017923111,-0.030400548,0.060762063,-0.040314417,0.033056393,-0.036359806,0.012983563,-0.060412955,-0.06965848,-0.10589443,-0.06546081,0.04929063,-0.015440694,0.046979792,0.017944736,-0.0069237044,0.014319078,-0.033025395,0.035039734,0.025207426,0.08141968,0.08638253,0.061456528,-0.014721112,0.039150305,0.05068088,0.005179398,0.04790304,0.014143741,-0.02794689,0.04528476,-0.03949859,-0.024653178,-0.0451048,-0.05888966,0.024651606,0.015138815,0.012423401,-0.032798704,0.05029271,0.042248912,-0.058257718,-0.082851306,0.014734597,0.021275694,0.054920223,0.12011314,0.047840767,-0.013571699,0.03483724,-0.02933903,-0.009521693,-0.0053152908,0.07152904,-0.019100986,-0.079872005,-0.014507056,-0.016328234,0.010011378,-0.048232093,0.02178199,0.033607524,-0.09414131,0.046579514,-0.13768871,3.0656566e-33,0.052996613,0.017269855,0.060853675,0.014511514,-0.032698434,0.04477135,-0.10536223,-0.022459323,0.008294989,-0.045295805,-0.09775318,-0.083988614,-0.010147326,-0.011401316,0.024040615,-0.07876563,-0.06358076,0.013274815,0.006236142,0.00035801184,-0.039917722,0.12929468,-0.08727803,-0.017362105,0.06924188,0.082077466,-0.03113603,-0.06685035,0.1053978,-0.008962676,0.04989588,-0.059498653,-0.08330167,0.0027157736,0.070085086,-0.0017104651,0.035496615,-0.056998096,0.031434815,0.058377977,-0.06105946,-0.025456877,-0.04086659,-0.07234556,0.060070194,-0.062157147,-0.025056062,0.07017121,0.0048824246,-0.015637891,0.042970408,0.00014859949,0.0759704,-0.021474594,-0.061872363,0.035940822,-0.053862415,-0.03462059,0.06657059,-0.0015828672,0.01820112,-0.00757757,-0.013821689,0.0288394,-0.038669266,0.037198275,-0.1048935,-0.08157394,0.056176346,0.07732759,-0.028430706,0.011415723,0.07497125,0.03665878,-0.009171982,-0.0602357,-0.08880874,0.03978418,0.0748268,0.080574825,0.02856386,0.07688674,-0.029213931,-0.03852416,0.004492549,-0.087079346,-0.105958715,-0.014034964,-0.02991438,0.041510828,0.0058762934,-0.008167885,-0.08872523,0.03711993,0.021816805,-5.603931e-33,0.055380683,-0.10651326,-0.01573894,-0.06364168,-0.04082814,0.07625506,0.078636065,-0.057893347,0.013660675,-0.028232593,0.09621814,-0.014439687,-0.008244476,-0.07311497,0.02805579,-0.06047347,-0.09874553,0.047581803,-0.022055114,-0.027857786,0.053182874,0.009331731,0.055331744,0.016963493,-0.026620226,0.05689453,-0.04329544,0.12286648,0.09004777,0.07825594,-0.026709676,0.067978725,-0.048730996,-0.027993405,-0.033264235,0.06948869,-0.030422999,0.016948134,-0.0031886783,-0.020330558,0.020614866,0.06680079,0.04973151,0.084590085,0.018201092,0.09471339,-0.01489146,0.04197593,0.052154154,-0.10181605,0.01773465,0.013963495,-0.034513764,0.023529002,0.050767373,0.065755665,0.07124339,-0.011604177,-0.03378615,0.0054477025,-0.07706136,-0.08067472,0.09855961,-0.026475964,0.00657374,0.051951893,0.006535965,0.054179907,0.098047964,-0.027107362,0.05466006,0.021408772,0.041907556,-0.0017171893,-0.030079443,-0.005841879,0.032729853,-0.07400499,0.055891972,-0.09387572,-0.039955545,0.051320836,0.020490998,-0.043681648,-0.0061732577,-0.064603455,0.036175232,0.049262114,0.020011619,0.019584175,-0.010597128,-0.002665398,-0.012392152,0.07998163,-0.026322566,-4.5628042e-08,0.0067176525,-0.10202733,0.07322031,-0.074462816,0.0027592003,0.070324466,-0.024721347,-0.06353622,0.029384688,-0.052392017,0.028037336,-0.0046115587,-0.036649615,0.016328959,0.04970066,0.021977624,-0.01307482,-0.010908446,-0.02784191,-0.024930649,-0.07811757,-0.0139069185,-0.08198179,0.057772268,-0.050994266,-0.05425821,-0.0377614,0.05755407,-0.042219624,0.05420267,-0.05229133,0.060956504,-5.6785324e-05,-0.040593367,-0.08947842,0.016120007,-0.010569456,-0.019579228,-0.06965124,-0.07854071,-0.0016129717,-0.011163477,-0.04045647,-0.007066564,0.06766417,-0.0022509785,0.015191781,0.035364795,-0.048410106,0.07898806,0.005439202,0.02023382,0.041552994,0.010732123,-0.06797294,0.04061461,-0.011893689,-0.08248123,0.019560512,-0.05546274,0.0060380474,0.0040437086,0.16214368,0.03467397 +1.1.1.335,"This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalysing the next step the pathway (EC 2.6.1.98, UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase). The enzyme also possesses an EC 1.1.99.2 (L-2-hydroxyglutarate dehydrogenase) activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD+. The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD+ as tightly and do not require 2-oxoglutarate to function.",384,1.0,-0.0616021,-0.052036922,-0.11289074,-0.06252082,-0.008794213,0.050959863,-0.092573285,0.0688642,0.02519511,0.07722933,-0.015187959,-0.078773394,-0.031452283,0.02600981,-0.044389382,0.08067859,-0.041614432,-0.023431754,0.0052366643,0.021404618,0.095209844,0.059511587,0.009329327,-0.008697783,0.015715761,0.052159578,0.06720281,0.00301384,-0.038355313,-0.06130422,-0.08656065,-0.12009474,0.06568335,-0.09814736,0.09335091,0.05899466,0.026800843,-0.0038206824,0.07218418,0.04089371,0.031153256,0.03525783,-0.090196654,-0.030944519,0.011694053,-0.06522414,0.009510684,0.10196607,0.06389926,-0.013808074,-0.020456463,-0.059429422,-0.00995921,0.02885003,-0.030759994,0.039103612,0.014822266,0.005642362,-0.025140846,-0.027728306,-0.06588069,-0.04049019,0.08564649,-0.009141444,0.029992998,-0.06463753,0.07886294,-0.06674721,0.0155570535,-0.00898806,-0.096509494,-0.05883229,0.031823594,0.07069043,0.03454418,0.0065713692,0.02398526,-0.05348087,0.08727034,-0.08053308,0.03670578,-0.034887828,-0.005323603,0.12672065,-0.004655856,-0.03952286,0.0019408701,-0.06074114,0.076378144,0.03732443,-0.0026832102,-0.020744333,-0.015502381,-0.026599078,-0.06504523,0.021807617,0.0024818387,0.07612756,0.05959077,-0.06987163,0.010860097,0.04929837,-0.05271869,-0.10597719,0.0055245417,-0.0112012485,-0.011548092,0.038764372,0.024307072,0.00072881236,0.02140016,0.001040298,0.014191363,-0.038706966,-0.03965601,0.1121642,0.033647403,-0.054283813,-0.051097423,-0.061765205,0.012473512,-0.03397879,0.08247445,0.033196863,0.005398336,0.01346732,-0.06701754,1.7758283e-33,0.056313686,-0.0035400386,-0.023616133,-0.001233899,0.036177285,-0.0064752037,-0.11597742,0.016271496,-0.059526775,0.0062323003,-0.07601303,-0.08773378,0.05600699,0.0102541065,-0.008031876,0.056012776,-0.03399095,-0.045365274,-0.038079,0.021828376,0.028782465,0.079935804,0.026450027,0.0047865924,0.081136756,0.099740356,0.041076146,0.03241231,0.03566836,-0.0006839676,0.060314,-0.06459001,-0.121820636,-0.05934951,0.06678475,-0.003116142,-0.044070322,-0.024723781,0.041869413,0.057694405,-0.00021296836,0.039063267,-0.029717695,-0.034180924,0.05610704,-0.07339442,-0.00018582902,0.087484024,0.050120693,0.02282399,0.08176039,-0.06449031,0.11752164,0.0029212825,-0.029445242,-0.02417785,-0.037624903,-0.02281849,0.08285951,0.112474725,0.070728846,0.035069037,-0.009648083,0.044765588,-0.04327885,-0.019365635,-0.05121438,0.0040245317,0.036861263,-0.025169503,0.0036532371,-0.018199112,0.07103182,0.030135175,1.5641219e-05,-0.06714393,0.0003554033,0.03730233,0.013758513,-0.030807123,0.011608828,-0.025275089,0.054119058,-0.0034752581,-0.061298758,0.0055012363,0.02301396,-0.03789184,-0.041392755,0.037905492,0.04360659,-0.046514284,-0.068188585,0.060491085,-0.0081234565,-3.1653238e-33,0.07166623,-0.09203385,0.026598332,-0.12785532,-0.061471283,0.059668574,0.03879571,0.016622605,0.040042743,-0.0445768,0.07642604,0.041403685,0.031737737,0.01537186,0.025014482,0.022875713,-0.061571654,0.08356383,-0.079080366,-0.056435358,0.035142705,0.05297493,-0.004661972,0.062475555,0.06255695,-0.026495611,-0.03355686,0.08655663,0.014083908,0.049724624,-0.0134906005,0.06106858,-0.06559196,-0.03748674,-0.015314258,0.038932245,-0.011655412,0.012522642,-0.008897409,0.0314093,-0.05465181,0.028177746,-0.04785404,-0.03051479,0.010393303,0.08769177,-0.038035642,-0.03589133,-0.048113365,0.016306633,0.06402153,-0.036103196,0.04678965,0.058592975,0.02096606,0.03041773,-0.07182299,0.027200254,0.03282264,-0.025830561,-0.019157726,-0.06582772,0.049272206,0.026943453,0.0740056,0.08271709,0.015081072,0.015601571,0.038679134,-0.032816816,-0.017233271,0.015921308,-0.009911201,0.01608199,-0.0061753658,0.010629521,-0.093822554,-0.04902242,0.02473775,-0.0106767835,-0.00036736275,-0.015040595,0.028469894,-0.010222135,-0.018502148,-0.017238462,0.06341199,0.125847,-0.07793801,0.05844759,-0.011270204,-0.025936317,-0.06976152,0.028800035,0.04474429,-5.1233144e-08,0.03149099,-0.034296583,0.0668641,-0.031309955,0.015228285,-0.01185778,-0.057590794,-0.010465789,0.050916478,-0.053886753,-0.00808936,0.10495816,0.019784505,-0.01368612,-0.03261887,0.016420195,-0.044573184,0.0174481,-0.026248751,-0.027483223,-0.09312912,-0.018417165,-0.11801227,0.0066285683,0.04082363,-0.06667931,0.005187498,-0.004212541,0.039143726,-0.032050908,-0.036212623,-0.0035781357,0.0152240265,-0.09107265,-0.09652645,-0.011730121,-0.03819349,-0.03925818,-0.03233664,0.051528335,0.0736239,-0.08206095,0.024599977,-0.008955131,0.037932985,0.015399697,-0.041354492,0.030796679,-0.039467096,-0.012392513,0.06601185,-0.034009535,0.003334098,-0.061165832,-0.13258444,-0.020207137,-0.068551145,-0.072435096,-0.0030692841,0.026598917,-0.04174185,-0.012769584,0.14283507,-0.03656729 +1.1.1.336,Part of the pathway for acetamido sugar biosynthesis in bacteria and archaea. The enzyme has no activity with NADP+.,384,1.0,-0.04586145,-0.0075851325,-0.112153694,-0.013422083,0.07369,0.050962456,-0.06954941,-0.006886304,0.0324994,0.017784046,0.03805468,-0.030231167,-0.06284492,-0.032712016,-0.05898006,0.020044707,-0.051905032,-0.058789365,0.07187326,0.012137142,0.06763848,0.047755014,0.0077393632,-0.05868341,0.08155296,0.064105086,0.040400147,-0.04420159,-0.04901369,-0.0339686,-0.017671,0.006235818,0.006419202,-0.056814082,0.04627541,0.09366539,-0.032797344,-0.008654248,0.07918602,-0.051449187,0.00960069,0.042630486,-0.066193216,0.023023987,0.0030528493,-0.035206247,0.013838595,0.024888486,0.021726599,-0.023927957,-0.044541124,-0.00054667844,0.020557133,0.0028656987,0.02423477,0.031795163,-0.011720988,-0.068209454,-0.00031179652,-0.048109792,0.007283218,-0.05802034,-0.0012146649,-0.00017314099,0.029146152,-0.061906915,0.07392208,-0.022463236,-0.010248575,-0.033437558,-0.12515174,-0.03582525,0.0043833223,0.04889679,0.01132443,0.008609172,-0.011732118,-0.04510014,0.070677914,0.008407737,0.019163717,-0.006909826,-0.013022406,0.08666567,0.049524046,-0.02049854,0.06556657,0.015089899,0.0515878,0.003179281,-0.02557175,-0.06075646,0.029343428,-0.019288048,-0.12609804,-0.0020531856,0.052550163,-0.035778083,-0.016107252,-0.026883285,-0.005255868,0.0772212,0.015398954,-0.07681475,-0.001258194,0.00821115,0.00032176406,0.1279145,-0.03164749,0.034220934,0.02528003,-0.062014133,0.026667146,-0.06462288,-0.0331575,0.07362278,-0.029798215,-0.072146505,-0.1005856,0.010366146,-0.032336134,-0.02111053,0.020615837,0.04562695,-0.0057558613,0.02305707,-0.07983512,-4.8857127e-35,0.10130294,0.03405416,-0.015245053,-0.09396622,0.09645251,0.024358265,-0.08898745,0.011391361,0.04367471,-0.01952251,-0.06695372,-0.1441784,0.023096476,-0.026599063,0.00042583424,0.07885238,-0.064797886,-0.08048976,0.033051472,0.013078899,-0.08537355,0.05663328,-0.02058784,0.045681383,-0.0030417817,0.04488007,-0.04039104,0.029981177,0.016814096,0.0007359995,0.064712875,-0.04145083,-0.13566665,0.019704757,0.1228939,0.050880775,-0.018502735,-0.046403356,-0.061179277,0.028954877,-0.036545996,0.10417403,0.016671477,-0.065625995,0.0051548947,-0.08662317,-0.02774213,0.08590211,0.059080686,0.074688114,-0.00043541638,-0.018756377,0.15941344,-0.021969303,-0.042188313,0.046124272,-0.06490509,-0.00402994,0.028300092,0.056010496,-0.002848653,-0.029658452,0.019572329,0.06647359,-0.056412052,0.08165856,-0.03031159,-0.042007003,0.09153964,0.008883555,-0.024370467,-0.025042754,0.030335905,0.076108694,-0.0027900015,-0.034908753,0.008137408,0.007486652,0.04313554,0.021446278,-0.031903103,-0.061282907,-0.005317936,-0.0082552675,0.022282101,0.04595768,-0.018989736,-0.012887368,0.026942192,0.021021292,0.02440197,0.03165623,-0.037583116,0.03020926,-0.0013168111,-2.5928035e-33,0.08947713,-0.093764104,0.049011923,-0.12871356,-0.060402244,0.124219485,-0.015478293,-0.082604155,0.006707116,-0.014942054,0.063791044,0.04790714,0.028751174,-0.028420074,0.012387901,-0.011068686,0.0060431585,0.115005575,-0.03736627,0.03547708,0.04603908,0.08652065,0.0036455884,-0.017281752,0.05497998,-0.006553058,-0.035585158,0.03254085,-0.013306987,0.008072012,0.035135463,0.02850612,-0.09068563,-0.11126157,-0.035929866,0.028803198,-0.030157477,0.025090756,-0.061058413,0.046591792,0.012323797,0.043755326,-0.030581145,0.031882636,0.060644742,0.003230519,-0.056787312,0.025209207,-0.049328323,-0.07910103,0.05152045,0.01328071,-0.040093586,0.024287894,0.07221259,0.057274364,-0.0032226625,0.05993604,0.06336889,-0.027948784,-0.047436245,-0.033057738,0.00471201,-0.014314709,0.10099052,0.025675472,0.0037084857,0.038658418,-0.004037267,-0.041715425,0.006089678,0.0020641023,0.03899617,0.08168335,0.010892419,-0.025488183,-0.10503942,-0.039209932,-0.011496321,-0.07613588,-0.018237589,-0.004382122,0.010156527,-0.021235501,-0.08925038,-0.034910955,0.009958538,0.035610184,-0.02173768,0.040584553,-0.026229763,0.050487153,-0.05183012,0.027092215,-0.006440635,-2.4286516e-08,0.08268148,0.02847421,0.049511872,-0.06168563,-0.01562309,0.06600931,0.014654599,0.025549604,0.060854625,0.0031698477,-0.013074206,0.1624089,0.016068192,0.021044862,-0.0550966,0.0011818432,0.0046642083,0.033549342,-0.06673548,-0.022182852,-0.1175249,0.0035734216,-0.06396911,0.055937827,0.042282004,-0.07490152,-0.0040064794,-0.017411424,0.017378617,-0.088481724,0.005739074,0.03746312,0.052158304,-0.107275166,-0.08270568,0.043727253,0.0037390974,-0.06903262,0.007653353,0.0155263385,-0.05075928,-0.043288544,-0.05875075,-0.006419686,0.005605347,0.072403826,0.05177071,0.012320564,-0.10707995,-0.006948271,0.018309752,-0.005068413,0.02090439,-0.10213871,-0.054902498,-0.02166043,0.014291653,-0.08582293,0.012860513,-0.0021834914,0.055419322,-0.025564656,0.066396326,-0.061730944 +1.1.1.337,"The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.",384,1.0,-0.023712868,-0.10165882,-0.0660847,-0.050665453,0.025325397,0.056500908,-0.12307302,-0.012878645,0.01785345,-0.03606491,-0.031212265,-0.08187556,-0.09756765,0.030923836,-0.059740786,0.06357105,-0.055758256,0.060455028,0.025071576,0.078482665,0.13043141,0.034412194,-0.025431793,0.017574186,0.05984906,0.039695006,0.05187406,-0.030837901,-0.034264028,-0.055239793,0.04193174,-0.009055739,0.049520243,-0.05435352,0.057292,0.06309083,-0.007872302,-0.1020327,0.09494119,-0.007855465,0.032177802,0.008918826,0.10114745,-0.05284608,-0.037507936,0.003562622,-0.018279538,0.01238773,0.09445448,-0.07570848,-0.06823658,-0.090699226,-0.059342667,0.03891551,-0.00081236626,0.07150732,-0.03320455,-0.019955339,0.02468664,0.013293044,0.06750067,0.049510594,0.04432895,0.019459672,0.0043758187,-0.029251272,0.02007589,-0.07867724,0.04039571,-0.023362912,-0.089586295,-0.011730274,0.018370995,0.012764071,0.011282249,-0.008825506,-0.015433308,-0.047483496,0.06117075,-0.07844377,-0.023504965,-0.009683023,0.005867614,0.034951504,-0.022493925,-0.04502135,-0.023953082,0.02887398,0.0626458,-0.026317023,0.0028648258,-0.046719372,-0.028101077,-0.066020176,-0.05389572,-0.065565765,0.02276553,0.110784665,0.03072002,-0.0032065655,0.038818225,-0.0016283181,0.010666073,-0.11407058,-0.03713512,-0.009358397,-0.04609373,0.053904105,0.00019137024,0.07427369,0.013162943,-0.025274051,0.065429814,0.034331787,-0.06451481,0.09257312,0.0019696134,-0.081700474,-0.07472588,0.021748327,-0.032761227,-0.09116719,0.112708814,-0.023455461,-0.030780174,0.02122506,-0.063149005,1.0752183e-33,0.05963436,-0.03613875,0.014348727,-0.043104973,0.06308604,-0.05258435,-0.076280296,0.0419167,-0.02286828,0.010746807,-0.099536024,0.019557914,0.018640963,0.043236308,-0.047770947,0.031026527,0.004791599,-0.03865614,-0.0028780012,-0.024947563,-0.055676524,0.08708613,-0.023014195,-0.006752396,0.0341713,-0.0081702005,0.07954339,0.023045883,0.02150628,0.0036420587,0.09337774,-0.106051154,-0.06647472,0.04697093,0.09186705,0.06829054,-0.018698443,-0.07402342,-0.027298704,-0.016658776,0.060269523,0.02765344,0.021114543,-0.052319713,0.026319148,-0.0006293293,-0.0002196961,0.10272014,0.031508513,-0.018969227,0.022791356,-0.018053113,-0.003914586,0.031107428,-0.02790096,-0.016347775,-0.032794595,-0.0015521239,0.103319176,0.05831301,-0.06385032,0.01797198,-0.008818953,-0.020601802,-0.0053971647,0.044262942,-0.08318941,-0.0059829005,0.0038460298,0.047071353,-0.0030934967,-0.03355247,-0.03259571,0.09554658,-0.009916107,-0.02808163,0.027200531,0.0047606607,0.019337889,0.01524651,0.012999971,0.015241097,0.019338105,0.035444636,-0.1049128,0.015454058,0.00679315,-0.026274096,-0.057050113,0.07853433,-0.0044225133,-0.07832703,-0.07488122,0.05427778,0.05548568,-3.2378063e-33,0.033662494,-0.08070727,0.02697152,-0.07536839,-0.03434061,0.060134705,0.07440162,0.012996747,0.02608336,-0.031695135,0.08543415,0.04948196,0.04673277,-0.042262312,0.030134246,-0.04515006,0.08134755,0.031764902,-0.0069894893,-0.0009588477,0.028252406,0.11003144,-0.027935227,-3.791214e-05,-0.0042139725,-0.0130602475,0.026223239,0.051399365,-0.02037283,0.120089225,0.05839109,0.0017443417,-0.029402351,-0.08438865,-0.07034963,0.0021135607,-0.04849069,-0.039502144,-0.013915999,0.017900595,0.03557283,0.032167092,-0.0194467,0.061337408,0.05991354,0.023948396,-0.080342986,0.009195829,-0.030893154,-0.09540933,-0.021105977,-0.05275071,0.052706588,-0.01899537,0.02066763,0.07732796,-0.0040464965,-0.012970615,0.0429285,-0.059652656,-0.061171114,-0.02666876,0.052361816,-0.13199478,0.0244246,0.04803368,-0.030564435,-0.052122645,0.057846427,-0.036263846,0.036238246,0.05421828,-0.01290042,0.06644659,-0.093235955,-0.04465852,-0.10828439,0.012873995,0.02738714,-0.024903791,0.035948716,-0.03235267,0.08572024,-0.03403782,0.024244094,-0.032351356,0.057331163,0.11893396,-0.015564841,0.009844486,0.007088056,0.027376711,-0.093895696,0.0271774,0.035143364,-4.4621245e-08,0.016057193,-0.009767205,0.0662657,-0.018251419,-0.12424899,0.031326625,0.051096994,0.047900066,0.0075602103,-0.032269746,0.0022720005,0.102914475,-0.054766286,-0.009766777,0.006719318,0.028054008,-0.07527379,0.050900277,-0.06459608,0.04336336,-0.0031079336,-0.017245214,-0.025989404,0.016181322,-0.03470585,-0.058544014,0.061430573,0.006903105,-0.019911814,-0.020765971,0.022789,0.039185192,-0.0071636206,-0.030007213,-0.080855414,-0.047281366,-0.10384443,-0.053014472,-0.013858598,-0.016741334,0.08369276,-0.015499193,-0.051246602,0.039288733,0.0121452445,-0.009908038,0.007019596,0.052005477,-0.066025406,-0.018743465,0.10330972,-0.007259337,-0.026974263,-0.0038503986,-0.05528334,-0.05850365,-0.0011265895,-0.05152166,-0.06949934,0.010948048,0.048245624,-0.038050413,0.1362531,0.005883736 +1.1.1.338,"The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate.",384,0.99999994,-0.05445386,-0.037017766,-0.061658207,-0.030379843,-0.04006198,0.09677812,-0.079577185,0.10717951,0.0037832016,-4.1619533e-05,-0.01014657,0.019564822,-0.052251685,0.048470184,-0.009266291,0.0303236,0.0011787133,0.04699722,0.046810184,0.002147092,0.13508345,-0.006422411,-0.034638952,-0.039364364,0.08034459,0.037764568,-0.026976462,-0.009263341,0.036784183,-0.03637737,-0.03271059,0.052894715,0.021225477,-0.08857907,0.058559153,0.07736244,-0.02416799,-0.09146581,0.06541001,-0.022777893,0.015670503,0.061005887,-0.1289022,0.01689657,-0.0024694174,-0.074212685,0.020369254,0.065661326,-0.0019334162,-0.06510138,-0.09090355,0.03096529,-0.018012298,0.038784012,0.019868735,-0.0154749965,0.020801414,-0.06539494,-0.01326568,-0.08672287,0.008690426,-0.056457262,0.039150268,0.00041801398,0.040901158,-0.041388456,0.07353827,-0.04638754,-0.0019655663,0.016350502,-0.16506916,-0.049019314,-0.006730867,0.054243118,-0.017814463,0.036097396,-0.02335466,-0.1282781,0.042340335,0.023186577,0.016566887,-0.0078106276,-0.026669858,0.04755369,0.081765614,-0.014033218,-0.00313052,-0.021494983,0.037221417,0.0089974925,-0.0224519,-0.0069197086,0.0049766893,-0.0388646,-0.13079321,0.008715451,0.031519946,0.009041789,0.030524282,-0.013875468,0.03161031,0.077984326,0.007540266,-0.1080125,-0.037194498,-0.0005491826,-0.048632987,0.100154,0.016050598,0.029502686,-0.05441075,0.027486578,0.0048325737,-0.031196952,-0.021047557,0.105822615,0.039348725,-0.04196685,-0.079639256,0.018507969,-0.017898953,-0.06439104,0.009728011,0.012437533,-0.00882012,-0.0245229,-0.057916667,2.4934077e-33,0.064999446,-0.011229155,-0.011593147,-0.06573723,0.022830578,-0.0045716963,-0.09728168,0.017286135,0.01878224,-0.027893659,-0.016998129,-0.09806348,0.0011331751,0.018696094,0.04758689,0.08568566,-0.030537644,-0.057871584,0.04661041,0.023262683,-0.050940976,0.034973033,0.021176942,0.0010155574,0.02378034,0.03215416,-0.0008905589,0.120684564,-0.013402396,0.008752476,0.11871962,-0.08501995,-0.12035171,0.027301842,0.06796694,0.0072829025,-0.095331796,-0.07124818,-0.00037157576,0.028811745,-0.04088817,0.06094235,0.04218726,0.017956177,0.01193015,-0.06803226,-0.031416573,0.083336785,0.033280257,0.04522287,0.010359661,0.011737284,0.058733705,-0.07195699,0.019600814,0.04643066,0.0070036356,-0.032061443,-0.024470791,0.06957646,-0.031246025,-0.025379004,0.0009553791,0.026276182,-0.04497852,0.007881229,-0.060848787,-0.005895033,0.02977417,-0.02960891,-0.008406976,-0.0013324457,-0.015009709,0.07371191,0.016438771,-0.076313555,0.052584752,0.040285934,0.063150525,0.0035713962,0.01912206,-0.06806006,-0.030790584,-0.01476474,-0.045643788,0.0091205435,0.017558763,-0.011468962,0.053385954,0.023809236,0.03563763,-0.02861741,-0.026552472,0.04826767,-0.003765655,-4.070646e-33,0.037451487,-0.022053374,0.031074565,-0.1042208,-0.06634181,0.04107133,0.03305503,-0.06342747,-0.019019416,-0.02505751,0.06451442,0.04613865,0.044748396,-0.01943995,0.004086807,0.052511547,0.055480402,0.018451266,-0.06922952,-0.026315603,0.008907641,0.13753237,0.0010037976,0.0077744946,-0.002303853,0.011005404,-0.1105232,0.030079361,0.0464106,0.044713154,0.041042887,-0.0012262217,-0.08978333,-0.07096662,0.000533299,-0.01057692,-0.044379193,0.015298375,0.0029989637,0.008305592,0.07888129,0.055841718,-0.01191692,0.033052776,0.05149528,0.014551773,-0.06080959,-0.078451,0.09113737,-0.04452348,0.052135017,0.049896855,-0.028553825,-0.0039383094,0.03060591,0.066314645,0.012851999,0.018945504,0.032293558,-0.020995228,-0.05888101,-0.0220334,0.036623627,-0.054758627,0.06180158,0.0264871,-0.010966661,-0.010220243,0.061139464,-0.05439994,0.03573869,0.05666402,-0.0017624504,-0.011825975,-0.07335257,-0.015062579,-0.119393356,0.00518403,-0.075068325,-0.010300601,0.04156477,0.012972311,-0.020735245,-0.048478197,-0.021989103,-0.06743743,-0.025232801,0.040161178,-0.028850012,-0.022639252,-0.042351622,0.019863745,-0.060744107,0.047946226,0.05640431,-3.542324e-08,-0.0013284032,-0.011645809,0.032861225,-0.039335392,-0.02986514,0.018790595,-0.012578977,-0.069791906,0.073385626,0.015226635,-0.035577968,0.1440027,0.0016023639,0.037094254,0.014004815,-0.019305207,-0.034825455,-0.019626658,-0.028328622,-0.042011924,-0.07019698,-0.008953709,-0.048092704,0.12439815,0.04619404,-0.042008292,0.051847253,-0.037101865,0.012500626,0.01599122,0.036585946,0.07614922,0.015560122,0.019068582,-0.05040283,-0.016718512,-0.01924791,-0.029708367,-0.06952211,0.08644114,0.025112744,-0.052236456,-0.1063693,0.070961356,0.048159104,0.03591215,0.04370469,-0.00520218,-0.067936905,-0.004464366,0.11386349,-0.04832973,-0.038580135,-0.091594815,-0.05707816,0.009890351,0.0696631,-0.05079344,-0.0075247274,-0.024614539,0.034233637,-0.07799121,0.18909086,-0.10073781 +1.1.1.339,"The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.",384,0.99999994,-0.05335947,-0.077417,-0.05738538,-0.022532247,-0.021071294,0.12240514,-0.0054194266,0.093588695,0.026398228,0.051603958,-0.021506391,-0.023724282,-0.07223279,0.07420379,-0.060590856,0.040248655,0.027714,0.007687134,0.073123425,-0.003773796,0.042914536,-0.039816357,0.0042518564,-0.05507968,0.0708931,-0.024889326,-0.02536447,-0.0037060468,-0.027010806,-0.03256471,-0.057872362,-0.023805529,0.07134391,-0.011617469,0.081085704,0.05305847,-0.011544526,-0.017872086,0.0628238,-0.07229781,0.034605548,0.031164851,-0.017558994,0.019329408,-0.018367931,-0.008419344,0.009725455,0.072683685,0.00055662997,0.0019901027,-0.04952664,-0.055880442,0.020602347,-0.022283494,0.046291787,-0.07188813,0.032663815,-0.11048756,0.026858151,-0.038820688,-0.010068703,-0.03633682,0.0016229589,0.025733022,0.011140204,-0.046793874,0.079143554,-0.022976933,-0.0013145364,0.003922732,-0.1317465,-0.022507502,-0.0062976168,0.047769226,0.0064733014,0.015862549,-0.0241709,-0.045125097,0.04500991,0.0019117586,0.016285822,0.06834723,-0.01525911,0.100671925,0.022270897,-0.024766227,0.044622112,0.04092605,0.03370325,0.005624832,-0.027214486,-0.021047173,-0.023046518,-0.015661012,-0.1391065,-0.026160972,-0.00077649386,-0.03810666,0.054833077,-0.020422498,0.024454918,0.047900673,0.08446983,-0.07456652,-0.028494041,-0.010892934,-0.07340833,0.084496364,0.007969278,0.026374532,-0.01166453,0.009448239,-0.07587842,-0.046015974,-0.06452632,0.08176374,0.033840757,-0.07264078,-0.098251216,-0.047402978,0.0013608752,-0.032418374,0.04976301,0.023990154,0.008776839,-0.02769897,-0.085302345,1.0759998e-33,0.062072743,-0.07088235,0.032420095,-0.021401245,0.06384004,0.016380426,-0.018148778,0.018423846,0.009200596,0.01567891,-0.080903545,-0.14515348,0.05112178,0.07289561,-0.004443624,0.100526534,-0.03647118,-0.15187582,0.006844938,0.004208949,0.02028618,0.082718424,0.017626988,0.004252857,0.05343037,0.0103342775,-0.06424517,0.050804097,0.03736721,-0.022246646,0.08119112,-0.06376141,-0.17373395,0.06262887,0.12666576,0.011552187,-0.019577453,-0.04787449,0.06755451,0.05894831,-0.034530565,0.091640234,0.009319009,-0.050404117,0.07605596,-0.034036208,-0.039722133,0.057157386,0.013618157,0.114672124,0.061374392,-0.042187158,0.09173039,-0.00036372247,-0.003747918,0.060614098,-0.06506694,0.040354937,-0.02680515,0.06598501,0.061185457,-0.02606732,0.027643222,-5.3749405e-05,-0.04049504,0.02286645,-0.05606226,-0.0132829575,0.056539897,0.03906541,-0.0081065325,-0.0074018445,0.016832892,0.03282032,-0.0045914985,-0.04875889,-0.027393727,-0.0033532893,0.001984275,0.009251541,-0.0023131508,-0.021044826,-0.0077477833,-0.024556575,-0.0830805,0.034512624,0.017395563,-0.043422922,-0.0437585,0.0049905363,0.0531246,-0.035498425,-0.07616117,0.08299898,0.0083959205,-4.184636e-33,0.07436529,-0.0663622,0.057138707,-0.0944624,-0.063921764,0.04423844,0.028313203,-0.017840123,-0.07969415,0.00731728,0.055657458,0.0686382,0.048322804,0.026655797,0.008566724,0.00039477102,-0.06405248,0.09416011,-0.06265819,0.057591733,-0.060195733,0.1046759,0.05456585,-0.070756614,0.04998068,-0.04858247,-0.034607492,0.07193572,-0.0035885747,0.0015126396,0.030321443,0.04130735,-0.12513463,-0.06868421,-0.0063596675,-0.046097394,-0.037989248,0.018614251,0.017652592,0.011914896,0.009669126,0.060469247,-0.030773066,0.07148291,0.044781502,0.056248747,-0.07921928,-0.014745289,0.02515957,-0.07970095,-0.029355628,-0.009521816,0.04627459,0.025965273,0.053531833,0.03550139,0.05101068,-0.010019556,-0.035894375,-0.035185337,-0.042960797,-0.043852236,0.055912808,-0.020510726,0.122317925,0.065364316,0.009671047,0.011078277,0.048328917,-0.05269646,0.04655686,0.025422934,-0.067257635,-0.011284353,-0.047840226,-0.050062887,-0.10804161,0.034608044,-0.0022433482,0.00778839,0.0233253,-0.026948437,0.0041511822,-0.0050775697,-0.04870362,-0.039583426,0.023600196,0.04394424,-0.03624116,0.052515324,-0.015211187,0.07254611,0.0047621513,0.032757435,0.004420016,-3.275386e-08,0.04061024,0.015505572,-0.01679378,-0.09147213,-0.058201868,0.044865977,-0.108461775,-0.08043409,0.011121044,0.05432389,0.018979797,0.09052684,-0.02154989,0.015639616,0.008356086,-0.07382467,-0.021934044,-0.0013230563,-0.032287907,0.007088816,-0.084160894,-0.011298183,-0.11378254,0.08530927,-0.011913636,-0.054376047,-0.010618758,-0.041328564,0.017813398,-0.020892458,-0.026843805,0.06354673,0.012502282,-0.0724648,-0.07233078,0.03744122,-0.0437854,-0.07415871,0.051812146,0.00849996,0.071495764,-0.05232914,-0.02550868,0.0048681432,0.003789991,0.036345016,0.014193497,-0.051728282,-0.05648396,0.05114959,0.063330874,-0.007499788,-0.06357954,-0.001895421,-0.06107509,0.021061102,-0.027337287,-0.051416744,0.0057482114,-0.006684085,-0.0009795922,-0.05108114,0.04918918,-0.033082236 +1.1.1.340,Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.,384,1.0,-0.0051747644,-0.005411312,-0.1424114,0.010658685,-0.068193205,0.02757284,-0.04418749,-0.0063510826,0.07570086,-0.04733936,0.033297036,0.0029578789,-0.04354572,0.013723473,-0.06747046,-0.028664036,-0.024261843,-0.007581172,0.07017565,-0.013495847,0.1263105,0.059477046,-0.0024111401,-0.095624745,0.083703905,-0.012636535,-0.037138212,0.007361809,0.015819289,-0.07935658,0.044618122,-0.01863726,0.051124312,-0.14202932,0.15396914,0.0656314,-0.039531834,-0.023256863,0.14209817,0.0669846,-0.032148935,-0.027165966,0.06825678,0.021704292,-0.06956808,0.03702726,0.023534644,0.10579411,-0.014149944,-0.062343705,-0.047896467,-0.053450197,-0.03963492,0.04063401,0.041044034,-0.0006953136,0.05258456,-0.024622494,0.007899749,-0.0990951,0.09276281,0.012769881,0.0011257197,-0.013099781,-0.13461235,0.016864846,0.022787973,-0.007502992,0.11287949,-0.006740558,-0.020447461,0.046571348,-0.014616813,0.052168593,0.02388825,0.025434623,-0.04365523,-0.028023893,-0.057586424,0.0028074344,0.058551487,0.043809805,-0.015027637,0.0880576,0.045958962,-0.043548666,-0.03237714,0.057485692,0.065464474,0.046109237,0.016041758,-0.044177808,0.0017875676,-0.04579896,-0.046336554,-0.0045471466,-0.05528311,0.0007767098,-0.0054637254,-0.027011963,-0.014839295,-0.023331394,0.017988369,0.020234575,0.014689529,0.050161228,-0.07137927,-0.0055328817,0.06006635,-0.032805633,-0.020933034,0.018734867,-0.0409926,-0.06325328,0.015701264,-0.029362101,0.07060993,-0.04006953,0.011981943,0.019480087,-0.019406948,0.040401764,0.007662587,0.029196758,0.027268361,0.03493122,-0.076044165,2.4443977e-33,0.012231971,0.022558255,0.04850719,-0.04845946,0.060199313,0.01707471,-0.0364925,-0.09911278,-0.0176131,-0.048550047,-0.08642894,-0.10792375,-0.0008040027,0.02454455,-0.0074661616,0.0198801,0.008780597,0.04852635,0.067611374,-0.009267858,0.047168266,0.06589749,-0.08089082,-0.014060659,0.004643402,0.022912174,0.024263967,0.016076079,0.07231782,-0.022580573,0.048027303,-0.026773443,-0.050236665,-0.04928952,0.08144176,-0.061901074,-0.033461206,-0.06813892,0.03681404,0.052608542,0.017748114,0.0537364,-0.016949719,0.025062604,0.112151556,0.016095294,-0.031779453,0.038053412,0.107782856,-0.0029154492,0.0009443305,0.010324821,0.09407195,0.03209765,-0.086986855,-0.03618125,-0.03242229,0.043540053,0.078869246,0.022169085,-0.0026478034,0.050971918,0.018955005,-0.036942203,0.021841655,0.014066411,-0.013129474,-0.004743351,-0.051118065,0.010727032,-0.08398855,-0.089054786,-0.019637639,-0.039343197,0.027789881,0.0073797577,-0.059427455,-0.0033818483,0.018122332,-0.019431716,-0.055353835,-0.0085226735,-0.025256217,-0.08580289,-0.027286347,0.019014416,-0.05783686,-0.03546903,0.046598442,0.08731358,-0.061736144,-0.055415254,-0.13075064,0.077853195,0.02082527,-3.2762684e-33,0.05422029,-0.06574101,0.0822769,-0.041540105,-0.09705232,0.081100196,-0.08720004,0.032334186,-0.0042391666,0.018937252,-0.014939419,0.027075907,0.0035534783,-0.05713996,-0.002241491,-0.02006923,0.06323724,0.15036425,0.01728612,0.042998888,-0.02229377,0.035766102,-0.039629053,-0.038342502,0.036574215,0.011836322,0.035358164,0.026787188,0.0023728306,0.0080864215,0.045486365,-0.035967506,-0.035955504,-0.057679605,-0.100036025,0.06598389,-0.06476556,-0.0091941655,0.078122534,0.03770724,0.064738594,0.0077978326,0.04249607,0.07437596,0.04360541,0.024019316,-0.09372915,0.050473955,0.021912431,-0.0042049447,0.004511132,0.009818656,0.009830453,-0.005601672,0.037482254,-0.04128992,-0.010995726,0.032431766,0.024442347,-0.06811812,0.006085731,-0.012937386,0.013378977,-0.026315005,0.12653889,0.061245084,-0.011010282,0.09118389,0.04212149,0.00031117938,-0.03723119,0.06963297,-0.03084366,0.007052567,0.05228297,0.05636514,-0.10658933,-0.078922585,-0.01677895,-0.002404949,-0.023224048,-0.066509545,0.06590157,-0.061382867,-0.01845113,-0.02701623,0.07934722,0.035304327,0.020962683,0.07849905,-0.013699351,0.017351402,-0.019127905,0.030344613,0.023502523,-2.5154245e-08,0.042191662,-0.0040048724,0.045326125,-0.0002542473,-0.019896608,-0.097644545,-0.038192388,-0.0004941443,0.017096024,0.036608998,-0.024721278,-0.052811626,0.030401694,-0.026293831,0.032209978,0.020761078,-0.04066783,-0.05852244,-0.0019325361,0.017581737,-0.038680177,0.02155774,-0.011667257,0.032998975,0.021829674,-0.092720084,0.10196723,-0.029323123,-0.0063368576,-0.001034664,0.02238761,-0.020097286,-0.061386224,0.0034183788,-0.04124643,-0.006366136,-0.10488423,-0.06161783,0.026501194,-0.061462913,0.0070295576,-0.05363966,0.010244559,0.047567487,-0.066991635,0.037528515,-0.04438772,-0.03545069,-0.09141202,-0.07402281,0.007130191,-0.003118101,-0.0028501158,0.049766716,-0.091093495,0.025104461,-0.0040880367,-0.021838883,-0.029410476,-0.020438015,-0.06615196,-0.072937585,0.15046637,-0.006257699 +1.1.1.341,"Isolated from Yersinia pseudotuberculosis [1,3] and Salmonella enterica [1,2].",384,1.0,-0.037235383,-0.065750666,-0.093557335,-0.022716116,-0.0054489053,0.029628878,-0.0064278413,0.086581826,0.029018348,-0.026272692,-0.028268823,0.053460374,0.01838202,0.08305811,-0.052086063,-0.043980885,-0.049430043,-0.012475863,-0.00022727069,-0.042836066,-0.039175924,0.040768854,0.047923222,-0.026282402,-0.018902576,0.07460207,0.042217776,0.059306588,0.02315102,0.012510669,-0.10896719,-0.03580451,-0.03431838,-0.05112818,0.08344757,0.01178713,0.060071945,0.024986928,0.12451768,-0.024701573,0.0220204,0.01612321,-0.003753846,-0.014462593,-0.038619865,0.035721205,-0.11306736,0.07149204,0.14637627,-0.064741485,-0.07074787,-0.02798096,-0.013255834,0.07537444,0.0032024889,-0.0019535995,0.015125904,-0.058879454,-0.0037184216,0.04790567,0.0139200855,-0.031081904,0.080648124,0.02755206,-0.028098,0.0083819255,-0.068441175,0.0575585,0.11569336,-0.003037607,0.02403391,0.04100689,-0.062281422,0.10361748,-0.018850941,-0.055193022,0.014161306,-0.0049067056,0.023139417,0.0711355,-0.08086388,0.012328201,0.07635504,0.06594208,-0.010980684,0.0045969496,0.021453993,0.05800211,0.04893118,0.038597174,-0.046895504,-0.01236604,0.06505726,-0.1145979,-0.0041519287,-0.044092134,0.059025794,-0.014526364,0.000493579,-0.031906858,-0.0144587215,-0.042674035,0.06375374,-0.024433188,0.00863075,0.03473772,-0.06128503,-0.005424078,0.052418098,-0.041699205,-0.016338622,0.05420713,0.001284706,-0.04923901,-0.04734297,-0.03860905,0.0529294,-0.039697655,0.02563957,-0.043759592,-0.05404822,-0.03706648,0.053427,-0.029035479,-0.026382737,-0.027483964,-0.07172409,3.3120058e-34,0.015280238,-0.05754512,0.053160038,-0.04880718,0.06209983,-0.008113109,0.03168969,-0.011203632,0.027656967,0.034879763,-0.062270336,-0.054327425,-0.002907405,-0.020047767,0.026208082,-0.0136209745,0.02476006,0.027500667,-0.026897084,-0.02362027,0.090340815,0.057146635,0.08619388,-0.026423056,0.05800491,-0.07618661,-0.036128044,-2.8755197e-05,0.037598576,-0.017578961,-0.0088610845,-0.02677345,-0.07909893,-0.011120785,0.05284567,-0.037533294,-0.0017221002,0.010356929,0.0128888795,0.09311212,0.025357109,0.047368154,0.008491193,0.061901122,0.0153683005,-0.010628429,-0.037335802,0.0041967053,0.018517673,0.019204685,-0.017758498,0.0008712921,-0.0065213637,-0.05454489,-0.040273502,-0.07185984,0.08933808,0.01206664,0.02515346,-0.0066971257,-0.017756307,0.08381383,-0.02602081,0.009138345,-0.013937305,-0.01574046,-0.011422551,0.019513592,-0.064405866,0.030804899,-0.071332835,0.050363965,-0.050735302,-0.09494981,0.044115227,-0.074624024,-0.06684403,-0.11336102,0.03804974,-0.047546394,-0.03916138,0.009413043,0.056036737,0.106531695,-0.13698119,0.070792906,0.014846034,0.015841354,-0.056323398,0.016689098,0.038955417,0.038651392,-0.116740935,0.048247408,-0.07155333,-1.6375573e-33,0.054106846,-0.00054815045,0.041725248,-0.08084111,-0.09561335,0.027424967,0.0060347803,0.100185916,0.06890407,-0.011743495,0.029718628,0.08539473,0.03282118,0.058533534,-0.05873063,0.08116441,0.052510932,0.051800843,-0.11944395,-0.010761775,-0.01375216,-0.0012900807,0.016510827,-0.06607361,-0.021855664,0.0033193347,0.026905116,0.053678412,-0.020160502,0.029606177,0.052685093,0.058630627,-0.0042602783,-0.096623935,-0.047742702,-0.046306472,-0.015915133,-0.08657254,0.025749166,-0.05839558,0.06316344,0.056899898,-0.040207107,0.13378707,0.018238293,0.07756759,-0.023061367,0.018342892,-0.044886265,0.060866408,-0.063001454,-0.07990343,0.024822379,0.029782614,-0.00031868365,-0.104832485,-0.064890966,-0.013978958,-0.06431228,-0.04783059,0.01667722,-0.05075143,-0.03742078,-0.03569516,0.08735375,0.052176487,-0.0053899204,0.027818983,0.020139951,-0.049657762,0.0032181516,0.041270953,-0.024605786,-0.028917242,0.0039696344,-0.038095683,-0.03353672,-0.026542075,0.07826562,0.07490429,0.030533662,0.015683686,-0.032463662,-0.0964987,0.08117179,-0.012306731,0.051366147,0.030751294,-0.030762035,0.031703476,0.04939769,0.014733213,-0.04075102,0.0476773,0.05456722,-2.4753502e-08,0.07352353,-0.019749423,-0.030849861,0.044231214,-0.01677458,-0.062679544,-0.07593926,-0.021825835,0.11905955,-0.0006378981,-0.04666879,0.021723153,-0.013984419,-0.0020243996,-0.004312187,0.03744146,-0.01522616,-0.04341305,0.02539929,-0.048405286,-0.0655024,-0.060160805,-0.0012780561,-0.032677427,0.021328969,-0.028930375,0.0155433975,-0.09671976,-0.03888566,0.0029885836,-0.080382675,0.006460253,-0.022453027,0.010909651,0.016900001,0.01425015,-0.034346264,0.08824933,0.04326987,-0.05207376,0.043155473,-0.047966834,-0.072211824,0.009757955,-0.030131865,0.031244991,-0.03147167,0.059973482,0.0052300165,-0.14146458,0.07840215,-0.012496003,0.09996185,0.025393186,-0.07144793,0.07612183,-0.02681251,-0.018475963,-0.0757185,0.0024603955,-0.08540392,-0.0027061359,0.08444402,0.024373561 +1.1.1.342,"The enzyme is involved in synthesis of paratose and tyvelose, unusual 3,6-dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria. Isolated from Salmonella enterica subsp. enterica serovar Typhi (Salmonella typhi).",384,0.99999994,0.0025733553,-0.08420172,-0.07306015,-0.0046751713,-0.054781135,0.027588442,0.049036708,0.02273256,0.039876945,-0.0065685804,0.017207952,-0.029494105,-0.047051482,0.028772242,-0.009633304,0.01306222,-0.018966664,-0.068977475,0.0055129174,-0.033615496,0.06947391,-0.0027049975,0.04289043,-0.023763811,0.00046174202,0.004146838,0.08283949,-2.3915338e-05,-0.00322854,-0.07693259,-0.08923993,-0.086127564,0.09022011,-0.04796699,0.090195484,0.008017183,0.06885654,-0.005840249,0.08923416,-0.025654117,0.022713697,-0.025618242,-0.008854359,0.005870834,-0.009462236,-0.011709404,0.003951421,0.046495993,0.053412132,-0.0033892547,-0.080741435,-0.08349818,0.0035910895,0.0041316417,0.008225557,-0.012911505,-0.019052837,-0.04737366,-0.0010485706,-0.047610365,0.00528027,0.007173514,0.09439476,0.009724325,-0.034252644,-0.064878695,0.033903446,-0.012522546,-0.00090453966,-0.052352272,-0.07284442,-0.03640875,-0.016471902,0.03528205,-0.041823953,-0.0017370306,0.064778164,-0.033801787,0.058142643,-0.018260878,0.06640273,-0.04403866,-0.032438718,0.17010759,-0.040285196,-0.031065287,0.0046433425,0.038279336,0.101312794,0.01555285,-0.018044736,-0.10020644,0.020843852,-0.07849452,-0.02662778,-0.027311709,-0.03944757,-0.05902722,0.11198867,0.011453759,-0.042653397,-0.03636709,0.05881766,-0.07934443,-0.046407383,0.023714,-0.0060594045,0.036013875,0.058520503,0.017070057,0.011190965,-0.026553191,0.086019434,-0.006604243,-0.085391924,0.008734565,0.0040306654,-0.08214533,-0.020467253,-0.048571553,-0.01386711,-0.025619563,0.0659416,0.07389713,0.02953407,0.0428839,-0.06586535,2.8882943e-33,0.06591217,0.00856869,0.004347544,-0.020122297,0.02588967,-0.03576201,0.029105155,0.0039068046,-0.08833804,0.049333766,-0.09684103,-0.16229646,0.0020536322,0.057410408,0.03548535,0.03805462,-0.008923696,0.017602481,-0.02727474,0.05937006,-0.044594783,0.074248865,0.04553452,-0.020749675,0.053145878,0.07178169,-0.05090754,-0.014090155,0.07692287,-0.033688884,0.106876306,-0.04953896,-0.09113405,0.06813076,0.16496614,0.031827208,-0.020884441,0.017906234,-0.030561045,0.017600214,-0.018523917,0.064862505,0.016360322,-0.024342004,-0.002558242,-0.081612214,-0.06981692,0.020090034,0.0956453,0.015499578,0.0045257057,0.011604617,0.06940232,-0.018177768,-0.015176154,-0.024339946,-0.007222905,0.05364482,0.081150025,9.385943e-05,-0.08139762,0.030653892,-0.048898373,-0.017149506,0.013800835,0.023471493,-0.0072304457,-0.008880023,0.019465663,0.026539246,-0.033513688,-0.023756549,-0.06339565,-0.006349837,-0.010841072,-0.013321741,-0.06403369,-0.05563198,0.048737966,-0.07143027,0.026299426,-0.07773214,0.038023353,0.00815286,-0.13252112,0.06682683,-0.04353371,-0.017598012,0.00084429566,0.07765814,-0.008658127,-0.0151938,-0.10127415,0.056997687,-0.015625259,-4.1500644e-33,0.04011837,-0.06266248,0.033777494,-0.12074114,-0.049926437,0.04487584,-0.009057766,0.03845852,0.06267183,0.04138303,0.0783045,0.04482942,0.050144505,-0.026832499,-0.009278919,0.023643116,0.026700346,0.123484865,-0.059557084,-0.094493665,-0.015160805,0.037593678,-0.003166136,-0.02154784,0.011501757,0.07008026,0.027213445,0.13749689,-0.051301826,0.032529343,-0.021581484,-0.01381657,0.009705731,-0.047719892,-0.026871685,-0.015464052,-0.004355996,0.0112418765,0.020507224,-0.0049448535,-0.05056463,0.05737308,0.052817263,0.07575743,-0.022523265,0.06975943,-0.09728691,0.005864915,0.011828664,0.026918655,-0.0041075745,-0.050505184,0.033961315,-0.025515229,-0.0013423838,0.02811945,-0.01599249,-0.020215482,-0.034106467,-0.06828258,-0.03420724,-0.066659346,0.102278106,0.0013262908,0.08397343,0.053564556,-0.041202568,-0.008723036,0.0041657677,-0.055197846,-0.030454317,0.021467373,-0.03451135,0.010256573,0.040381078,-0.064987436,-0.098835774,-0.049545646,0.0816787,-0.019985048,0.021662613,-0.037957966,-0.0020747401,0.0116187055,0.03519691,-0.02269524,-0.0012342962,0.07392703,0.019766003,0.06865938,-0.030624993,0.03625638,-0.0083907,0.0048967833,0.058182854,-3.537542e-08,0.040909417,-0.093319155,-0.0292168,-0.008133144,-0.042364452,0.017226474,-0.065140374,0.003173983,0.062049225,-0.03950247,0.0090139555,0.13602528,0.020813806,-0.044760913,-0.01594677,-0.043387357,-0.032055076,-0.0045765257,-0.06391193,-0.037490357,-0.020029465,-0.021249555,-0.07566698,0.02820754,0.08556828,-0.06215615,-0.03508643,-0.0073524076,-0.02112083,0.0035352663,-0.054536868,0.069567546,-0.028517121,-0.04310887,-0.060114704,0.04298117,-0.056340743,-0.03941153,-0.006487431,0.021704243,0.06671194,0.02003044,-0.07935524,-0.046065528,-0.028362097,0.029299546,-0.04614225,0.043120187,-0.051733073,-0.0004242885,0.018791307,0.010387108,-0.019371781,0.01125168,-0.07791009,-0.037188206,0.021096017,-0.042790435,0.004818213,0.020734394,0.03400889,0.043675,0.22167039,-0.05005486 +1.2.1.85,"This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. Has lower activity with benzaldehyde [1]. Activity with NAD+ is more than 10-fold higher than with NADP+ [3]. cf. EC 1.2.1.32, aminomuconate-semialdehyde dehydrogenase.",384,1.0,0.00222109,-0.0028842206,-0.09717655,-0.08155382,0.067000896,0.06230456,-0.09322649,0.05867778,0.0687332,0.0020479849,-0.00672644,-0.012173295,-0.08406164,0.0048742355,-0.053368244,0.018725313,-0.05833557,0.012445599,0.016076522,-0.006790571,-0.002948878,0.021474369,0.04078742,-0.032561526,0.046920944,0.045270678,0.0283651,0.009512317,-0.051517323,-0.0254174,0.057386443,0.019636288,-0.023028985,-0.03649226,-0.007665722,0.061645426,-0.06434031,-0.02554859,0.04698415,0.043471467,-0.01903559,-0.012634941,-0.11275649,-0.06587588,0.015702542,-0.0392212,-0.0012751681,0.05601467,0.037116837,-0.048091922,-0.030739354,0.047445685,0.051874496,0.02914795,0.007385234,0.004166811,-0.011062712,-0.04000833,-0.06793366,-0.0044323695,0.0123250205,-0.014586984,-0.036925647,0.037976526,0.043082055,-0.057475004,0.009922395,-0.034114983,0.04047329,-0.028275514,-0.11717487,-0.05387397,-0.029017728,-0.00548039,-0.029387614,0.054202247,0.0006918966,-0.05261768,0.09713693,-0.07737619,0.04963847,0.03625053,0.030739788,0.08392452,0.05458035,0.006583699,0.020110372,-0.035663277,0.030917041,0.048621047,0.04596149,0.0073594246,-0.02570303,0.050183073,-0.08684013,0.04974777,0.026175985,0.039607655,-0.002156284,-0.0064979168,-0.0025990685,0.11974438,-0.032642942,-0.09984517,-0.08086877,0.060646582,0.013697071,0.15722154,-0.012748872,-0.03218857,0.027145833,-0.059401482,-0.039872218,-0.099488586,0.03552958,0.14633265,0.085681975,-0.051692903,-0.07136915,-0.01223668,0.004064549,-0.052144036,0.0029171407,0.0076425555,-0.06445569,0.03782209,-0.08430053,1.7699958e-33,0.08168123,0.0034326927,-0.059085667,-0.03087422,0.08574147,0.009246212,-0.10648403,0.03879261,-0.06917022,-0.0691847,-0.028918074,-0.04253396,-0.009991268,-0.05652931,0.0046351394,-0.033266876,-0.03970017,-0.023433587,0.026647339,0.022796858,0.055419397,0.030462364,0.010800437,0.01768869,0.0477782,0.0074425535,-0.06113202,0.05317133,-0.032657582,-0.0008087504,0.054398663,-0.09717954,-0.14626244,-0.00255517,0.017475773,-0.03256265,-0.0661296,-0.007407111,0.008099581,0.088989034,-0.0003616555,0.034445934,0.038187146,-0.0391095,0.050849352,-0.064137906,0.044714656,0.12882875,0.028780041,0.050655555,0.09212678,-0.0361128,0.08477196,-0.07333366,-0.05355735,0.06268576,-0.0042813015,-0.0143076535,0.06001542,0.101948746,0.030613605,0.018372916,-0.04926631,0.10154717,0.011904145,-0.035377797,-0.06378741,-0.017527577,0.06299957,0.041627157,-0.049579293,0.053202134,0.07855516,0.031103984,0.046967924,-0.04819316,-0.050208688,-0.02909768,0.05544877,0.023244502,-0.010520849,0.018649682,-0.024344549,-0.036026716,0.0071837595,0.058125213,-0.035750892,-0.0821963,-0.01203898,0.051437486,0.015148638,-0.032581277,-0.034837987,-0.02428227,0.065186046,-3.4623264e-33,0.09326572,-0.073410735,-0.00820848,-0.08885696,-0.05724832,0.12033312,0.048240844,-0.023311054,-0.025638307,-0.012738181,0.05599196,0.022643689,0.04276835,-0.018798236,0.035858575,-0.030417157,-0.03275174,0.05536833,-0.0026246372,-0.02541745,0.06572031,0.104001574,-0.008921121,0.010364925,0.018853683,-0.049719773,-0.047819495,0.042080984,0.08190787,-0.0026207964,0.013745013,0.021474533,-0.030403346,0.0008567281,0.041050535,0.111317314,-0.06919527,-0.025645847,0.01441583,0.016964948,-0.011945018,-0.009932461,-0.0733907,0.030458838,0.043473072,0.022892911,-0.13155988,0.015233796,0.006063104,-0.08327436,0.029871237,-0.0020284913,-0.0241004,0.04927753,0.06416333,0.052976575,0.006163626,-0.024888087,0.038430452,0.050644957,-0.0060673803,-0.05630133,0.01167943,0.008070474,0.06885065,0.043501172,-0.023356836,0.07249974,0.03141042,-0.031512745,0.09241972,0.0006142891,-0.011440495,0.025776608,-0.06282425,-0.013061177,-0.02509887,0.010591305,-0.023110395,0.02958615,0.05584534,-0.027938686,-0.016193338,-0.0978424,-0.04524364,-0.086920366,0.005996203,0.08168983,-0.103230245,0.071642034,0.04835978,0.0054549766,-0.049756803,0.03070081,-0.02173954,-4.1098346e-08,-0.0037005057,-0.04042231,0.028902264,-0.06440238,0.036789034,-0.009792433,0.060314037,-0.060188297,0.022061663,-0.07014764,0.01975981,0.06101901,0.03277739,0.035382435,0.07393022,-0.0028882762,-0.018940153,0.0028165067,-0.029945286,0.0022548074,-0.054432936,0.0063433587,-0.09174262,-0.03945765,0.030612057,-0.061126325,-0.01114943,0.0087117925,0.03277824,-0.05187399,0.0026772786,0.034301095,0.04772457,-0.008723135,-0.0091801165,0.020933969,-0.096781544,-0.052956514,-0.061968744,0.011424943,0.0069649215,-0.1183591,-0.007534038,-0.013242679,0.005527635,0.043727513,0.004940819,0.033022765,-0.06503373,-0.0035296592,0.04775251,-0.023774987,0.050932143,-0.048536934,-0.120509446,0.06544065,-0.03823593,-0.07636602,-0.0026767326,-0.09876149,0.01818492,0.006327767,0.09712891,0.0023244503 +1.2.1.86,Does not act on neral.,384,0.99999994,0.021337947,-0.028120404,0.010451075,-0.04618864,-0.028454004,-0.018731408,0.026896559,-0.03552503,0.02245647,-0.026223581,0.067330524,-0.017631387,-0.035146695,0.03464171,-0.012741631,0.020211445,0.028916596,-0.01799783,0.011707647,0.005378991,0.003673434,0.031873498,-0.014933174,-0.063497804,-0.04902619,-0.0623937,-0.037103146,-0.03859949,0.015661022,-0.09365891,-0.053944856,0.010805307,-0.069090225,0.033158116,0.013769569,0.020126028,-0.061590496,0.08740455,0.009084985,0.05682206,0.014983002,-0.026046684,-0.10072324,-0.021038894,-9.811363e-05,-0.04891719,-0.053912878,-0.06853232,-0.004997728,0.023936396,-0.12418883,-0.015221116,0.032306813,0.047520705,0.022389933,0.05033868,0.008312063,-0.032226082,0.06869386,-0.0394473,0.07699046,0.006776412,-0.046347868,0.010071036,0.02780404,0.054041825,0.0010099123,-0.029078078,0.0066146147,0.020643951,0.08278627,-0.045539346,0.0176942,-0.042875268,-0.065693215,0.022664879,0.0040540346,-0.00769826,0.05319938,0.032949645,-0.060755353,-0.04340561,0.018191414,0.041741915,0.078375414,-0.017284287,-0.06147031,-0.04600484,-0.10052092,0.07081775,-0.062567025,-0.00681886,0.007482343,-0.06111358,-0.0065643718,-0.001957391,-0.030725796,0.047221016,-0.17007451,0.07134602,0.017653154,0.1017011,-0.072452515,0.038107425,0.007995689,0.038136482,0.09448399,-0.06217507,-0.04267885,0.0636676,-0.05658538,-0.04233615,0.0576087,0.011619459,-0.003572749,0.029776333,0.0007587962,0.076084055,-0.11307217,-0.004245783,0.101931915,-0.030246666,-0.04975407,0.098145895,-0.0024657703,0.047492716,0.03635357,-1.845097e-33,0.036240853,-0.063771255,-0.030947533,0.018503299,0.001815917,0.024778536,-0.042922705,0.013980411,-0.007849616,0.0076042884,0.06945888,-0.048471335,0.00966437,-0.016556043,-0.004568645,0.11162004,0.026281638,-0.040508967,-0.009073775,0.02881809,0.06010081,0.14673358,-0.053502116,-0.05838764,-0.098858066,0.0012915037,-0.016555203,0.009962929,-0.08176802,-0.023081994,-0.034455705,-0.019160165,0.08496378,0.074866615,0.018558979,0.052148547,-0.09226658,-0.0035143043,-0.0259343,0.0051728953,-0.040150344,0.08820268,-0.022869792,-0.08123112,-0.057417087,-0.04606262,0.12690835,-0.008941023,0.049389236,-0.014817745,0.13512035,0.021994866,0.005864636,-0.012550581,0.05480284,0.013330512,0.008989172,0.05680579,0.008554308,0.042402525,0.047310863,-0.12067505,-0.01611824,-0.07618269,-0.043805137,0.061232656,-0.056699175,-0.023737421,-0.04592983,-0.047557503,-0.054987147,0.056644604,0.06913398,0.07061424,-0.042729914,-0.04866247,-0.0038621582,-0.031502813,-0.016735291,0.0054419506,-0.029522186,-0.07058307,0.040058497,-0.004684409,0.035194673,-0.1298234,0.035469618,0.017606936,-0.00500297,-0.029744964,0.06872474,-0.0011277872,-0.08762486,0.030701011,0.017393041,5.583741e-34,-0.086678624,0.00277811,-0.016684396,-0.021379264,-0.023034092,0.03740772,0.021905778,0.064639285,0.05802168,-0.0291419,0.061938073,0.048411917,-0.011499779,-0.007870191,0.058985975,0.008595911,0.040533505,0.048278842,0.008399448,-0.035516422,0.04220064,0.11677316,-0.081913106,0.056840926,-0.03692123,0.1232443,0.0042510857,0.0059628594,-0.05212867,-0.01899439,0.040158466,0.013466014,-0.06938119,-0.05747951,-0.001914712,0.07067325,-0.06611124,0.050143942,-0.07624175,-0.0568741,0.09742538,0.050756447,0.03755722,0.03009291,0.015908986,-0.0018855475,0.053807974,0.049234457,0.0025860248,-0.020939348,-0.052745517,-0.042433158,-0.015318477,0.045181043,0.05377564,0.093935736,0.025532654,-0.033065777,0.00020735853,-0.02022988,0.019937234,0.04565331,-0.04620513,-0.09013834,-0.0061398083,0.07359966,-0.016574051,0.13695835,0.055538565,0.0103817,0.023143489,0.03351231,-0.007728729,-0.10483983,-0.05484465,0.033979416,-0.01858749,-0.024786398,-0.014972415,-0.13205175,-0.041917406,-0.017894858,-0.08116753,0.026210178,0.030059077,0.060932904,-0.0077086156,-0.049459327,0.011449213,0.0019221273,-0.013413532,-0.009126318,0.036455527,0.06399207,0.010476464,-1.4384166e-08,-0.0023368124,0.04445005,0.052358,-0.022294855,-0.027179351,0.00393869,0.04891371,-0.11892802,-0.0034746383,0.13959622,0.026324911,0.0017571572,0.000633749,-0.14320666,0.06004657,0.008725235,0.021625666,0.017328313,-0.053262345,0.0131031545,-0.06754672,0.0025533135,-0.0296775,0.07016237,-0.056317646,-0.05216028,0.055001892,-0.018765945,0.04671414,0.007391192,0.04787594,0.07367435,0.020157259,-0.02985061,-0.050335024,-0.023247669,0.066854075,0.015005731,0.0109413555,-0.028788624,0.002980283,0.043203723,-0.023728697,0.025918256,-0.057841893,-0.0072054924,-0.012253201,-0.09315752,0.02027283,0.029199753,0.07387612,0.042202458,0.015427141,0.060420603,0.022567047,0.008765976,-0.012356525,0.01106852,0.028651161,0.005499519,0.03640841,-0.104120865,-0.008100159,0.02026387 +1.3.1.95,"Contains FAD. The reaction is catalysed in the opposite direction to that shown. The enzyme from the bacterium Clostridium propionicum is a complex that includes an electron-transfer flavoprotein (ETF). The ETF is reduced by NADH and transfers the electrons to the active site. Catalyses a step in a pathway for L-alanine fermentation to propanoate [1]. cf. EC 1.3.1.84, acrylyl-CoA reductase (NADPH).",384,1.0,-0.016563019,-0.022723723,-0.1117356,-0.016618557,0.13335305,0.039279055,-0.022978036,0.010301128,0.034455802,0.038518306,0.0039799153,-0.06418785,-0.00867174,0.0031013908,-0.026950456,-0.004819142,-0.06193437,-0.024677005,0.011405325,-0.029159207,0.0030449096,0.041619837,0.013873201,-0.013964148,0.06654155,0.07566214,0.03496638,-0.027782379,-0.034370027,-0.062892236,0.031932406,-0.017518926,0.0039836005,-0.04800168,0.02100903,0.04577461,-0.048063118,-0.03972834,0.051903494,0.043079805,0.053617336,-0.020536453,0.030668868,-0.049250845,-0.03983419,0.032052662,-0.008605066,0.06746207,0.018071542,0.0065343846,-0.013861953,-0.04011226,-0.050026212,0.009517443,0.035695232,0.019079108,-0.00093149417,-0.058359176,0.009543567,-0.0013194765,0.059817404,-0.048286747,-0.029259378,0.023310276,-0.026736435,-0.09010964,-0.01180351,-0.065226294,0.040279537,-0.086324394,-0.02504037,-0.044874474,-0.022392983,-0.01745922,0.12358223,0.014552889,0.00022504143,-0.061641853,0.028185597,-0.02510815,0.02249827,-0.021126105,0.01718074,0.048980556,0.038815986,-0.009913328,0.0660863,-0.0034405745,0.030084725,0.00957664,0.03149223,0.016351255,0.026180765,-0.0353241,-0.06945047,0.09113771,0.0072828955,-0.014184146,0.015312502,4.718308e-05,-0.04847831,0.09720059,-0.04540119,-0.097199954,-0.12608014,-0.053683177,0.0022905255,0.19613282,-0.05251425,-0.03562235,0.042453997,0.0066566514,0.07173841,0.025122356,0.018131249,0.05070346,0.015875217,-0.088969976,-0.057679884,-0.062167637,0.0020569654,0.032393333,0.005077849,0.1250422,-0.012559292,0.031470772,-0.10680805,1.7199378e-33,0.04998831,0.06622643,-0.031417616,-0.06603712,0.018099494,-0.0006222073,-0.050289575,0.007631282,0.00030191668,-0.035259586,-0.024178201,-0.034736097,0.043380078,0.0015843143,-0.041031305,-0.050340492,0.0017434045,0.06287578,0.040259,-0.015250497,0.06566017,0.06567403,0.013355804,0.031261403,0.04693097,0.002776644,-0.0050354726,0.020383228,-0.0018474368,-0.006077721,0.022228451,-0.05999125,-0.085886754,-0.027627135,0.0018199624,-0.0148695605,-0.056454323,-0.08661852,-0.020368857,0.068268664,-0.052596632,0.051330425,-0.026057536,0.0054015536,-0.0039188443,-0.040173445,-0.018915571,0.1268168,-0.0052981726,0.08034796,0.05978274,-0.05000398,0.17043056,-0.051032614,-0.08129094,0.08544168,-0.06251126,-0.0039772084,0.045919433,0.021445757,0.017970981,0.11408899,-0.044471204,0.08186336,-0.04956448,0.016698191,-0.015459714,-0.103574455,0.0953994,0.084962934,-0.034066606,0.028411958,0.054070186,-0.0075456216,0.09064749,-0.017069181,-0.124564916,-0.05185218,0.003233089,0.019494802,-0.0553969,0.01572079,-0.02149283,0.007088432,0.0007412217,-0.05658048,-0.11111661,-0.029264476,0.011242074,-0.0046888483,0.055196166,-0.063221835,-0.018422836,-0.007378164,0.01922527,-8.043053e-34,0.09283041,-0.13601942,0.027193576,-0.044900533,-0.053081032,0.03589704,0.02419445,-0.06552442,0.045158885,-0.021005599,0.070750974,0.0045748926,0.02809946,-0.05924871,0.016892236,-0.04432695,0.05077782,0.064139016,0.012659232,-0.016591445,-0.010576475,0.015544274,0.07837373,0.0048287185,0.06449262,-0.015331512,0.010854387,0.045095865,0.039135143,0.009831858,0.005780362,0.005881344,-0.042862613,-0.0324612,-0.047183454,0.115904264,-0.027171044,0.0061771087,0.018420283,0.0050019445,-0.020485768,0.021626618,-0.061941363,0.044205956,0.032510348,-0.009998038,-0.05099302,0.03359389,0.07799075,-0.038237736,0.00468967,-0.00254613,-0.002715183,-0.07199613,0.03571491,0.046467185,0.029843722,-0.015060745,-0.016005848,-0.06393087,-0.050938997,-0.08800987,0.020173071,0.0162148,0.07601693,0.040387448,-0.02161429,0.047226105,0.043854665,-0.05136223,0.14574844,0.054332867,0.033932753,0.06610151,0.020192238,-0.06235388,0.03214367,0.0053362893,-0.016862549,0.02524971,0.036085237,-0.035160147,0.0074720844,-0.059047807,-0.0390857,-0.026356744,0.014843549,0.06245058,-0.026094215,0.059467196,-0.07154195,0.0013743301,0.050026514,0.066146106,0.073217094,-4.155648e-08,0.015309734,-0.037539657,0.08592125,-0.013730912,0.051960684,0.06472433,0.02032369,-0.037628494,-0.008140809,-0.06230621,-0.058353074,0.099969834,0.067122005,0.016973294,0.04656381,0.026436517,-0.0077349646,-0.021394566,-0.058807883,-0.04457023,-0.048883397,-0.036769886,-0.13905907,0.077078134,0.037999183,-0.034899384,0.02140258,-0.028423946,-0.00013851105,-0.038320106,0.019964831,-0.016109563,0.008724684,-0.015062822,-0.0532939,-0.00030686852,0.04698539,-0.012622626,-0.013316884,0.041204326,-0.03408643,0.0068408847,-0.079178095,-0.018275883,-0.068657644,0.020791754,-0.03558736,-0.01219397,-0.07781935,-0.027518393,0.08818612,-0.022351712,-0.01431946,0.003191757,-0.055553254,-0.018592363,-0.0381806,-0.083562426,0.026987312,-0.022474576,0.05580649,0.06125033,0.19330321,-0.031734027 +1.3.1.96,"Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. cf. EC 2.5.1.21, squalene synthase, where squalene is formed directly from farnesyl diphosphate.",384,0.99999994,-0.07307992,-0.08889232,-0.057335395,-0.008914489,-0.022009246,0.049994007,-0.10349395,-0.0062430603,0.0026503254,0.052992832,0.082157776,-0.14755617,-0.04626127,0.009992619,-0.04975221,0.028058425,-0.042625822,-0.038374964,0.043707088,0.024676718,0.15026946,0.0850704,0.008804703,-0.02502096,0.049540553,0.017491218,-0.01788532,-0.0015960955,0.04785526,-0.10339529,0.042293478,0.019258294,-0.021100542,-0.048544995,0.06733805,0.044945803,0.0034368963,-0.050185878,0.16013452,0.10492895,-0.0018028213,-0.00019788355,0.039334964,-0.013820516,0.037212323,0.03576091,-0.027872184,0.1366239,0.033428434,-0.07116231,-0.04454691,-0.058984455,-0.022934346,0.008805505,-0.024975765,-0.050303865,0.08830748,-0.0035845898,0.058980033,0.012807656,0.12686975,-0.009195295,0.06445782,-0.026747718,-0.09625761,-0.014800169,-0.0313035,-0.03931062,0.052563727,-0.029130463,-0.08037479,-0.057881556,-0.0361485,0.028011065,0.09547117,0.059034,0.017749099,-0.08829004,-0.022620123,0.02783969,0.015769875,-0.03940963,0.0021057012,0.035915762,-0.014618333,-0.08027815,0.062628485,0.048156865,0.0022263338,0.015465286,-0.057147555,0.008733199,0.02637551,-0.062354233,-0.027763948,0.033163335,-0.0053955433,0.06754308,0.04585503,-0.023983728,0.031120652,-0.11023763,-0.012772978,-0.111239,-0.017280202,0.012096543,0.039065327,0.03128513,0.026305629,-0.027408125,-0.052772146,0.075208284,-0.029954962,-0.01972585,-0.0034008615,0.028289735,0.05433291,-0.044267394,-0.0039042148,0.0035423385,-0.030148113,0.028459817,-0.013348404,0.07307102,-0.0025362887,-0.018453686,-0.085706346,2.8983925e-33,0.025499104,0.01567361,0.018010587,-0.0693618,-0.00013091248,0.009323914,-0.058069125,-0.05306532,-0.047431853,-0.06535158,-0.008275202,-0.0008801231,0.0066240137,0.030090068,-0.07263825,-0.06935566,0.045108702,0.026166543,0.042806387,-0.10282716,0.024872925,0.05041805,-0.058226664,-0.021000063,0.07187897,0.066078894,0.045276515,-0.09326619,0.03443991,-0.048099313,0.047294073,-0.05664222,-0.071372375,-0.003007688,0.04437461,-0.060229965,-0.04359352,-0.0633974,-0.04913983,-0.024451269,0.02508942,0.06730353,0.0055241454,-0.03124836,0.07894087,0.018492557,-0.05235214,0.044335622,0.10493103,-0.036034893,-0.05468776,0.0109834485,0.086594954,0.025809258,-0.026092239,-0.02141369,-0.04296226,-0.027575057,0.025312591,0.023749134,0.034854148,0.12908413,-0.02948282,0.00934512,-0.03447138,-0.014963503,-0.024569249,-0.0030007968,0.0052023763,0.014936891,-0.069935545,0.008464878,0.012755642,-0.06213655,0.023352655,-0.025124876,-0.049767084,-0.00818683,-0.03964881,-0.0355032,-0.044691466,-0.0026944943,0.011688189,-0.052871533,-0.08146163,0.033191413,-0.055869296,-0.0032546218,0.03608546,0.10284064,-0.0057615004,-0.08399007,-0.10402093,0.053749155,0.0039429273,-2.9526385e-33,0.06949303,0.0028820399,0.06696635,-0.06048542,-0.0051507917,0.051432814,-0.0029002863,0.04140272,0.009334583,0.0023986283,0.016052578,-0.008531775,0.092741504,-0.09087026,0.02625065,-0.011044468,0.10900489,0.034193054,0.025025848,0.009679832,-0.058259208,0.03373693,0.01426698,-0.03175819,0.037808083,0.020048792,0.00762802,0.113599256,0.018323911,0.017300721,0.0166483,0.045467366,-0.02176007,-0.071042985,-0.053397216,-0.0027485115,-0.08639685,0.0041728895,0.017176233,0.018352313,0.02173405,0.010361686,-0.05238103,0.09096491,0.053806752,0.09896528,0.011187873,0.019686807,-0.022680327,0.0009600187,0.016997883,0.05173475,0.031848818,-0.018620016,0.04026997,-0.002522929,-0.009338311,0.050780427,0.040962614,-0.007299504,0.029673353,-0.05895036,0.002839363,-0.077814475,0.027558915,0.07126669,-0.049022455,0.058354218,0.045078058,-0.043147292,0.108261056,0.110465266,-0.058249537,-0.020531854,0.0061902604,0.0465108,-0.039306253,-0.10576028,-0.02155547,-0.025624959,0.049228087,-0.003972627,0.04725389,-0.019448018,0.035571676,-0.04126259,0.042093493,0.018520497,-0.03311154,0.05792635,-0.06420431,-0.016939804,-0.08508644,0.049425606,0.04071678,-3.0011982e-08,0.0064388923,0.031641852,0.10906384,0.025582878,-0.02559651,0.045059886,0.04037669,0.0514663,0.037190203,0.008479701,-0.033601314,-0.041005537,0.08932474,-0.021540185,0.0946228,-0.009566235,-0.08743878,0.0017903429,0.034831543,0.01262833,-0.00012223741,-0.06661172,-0.077710554,0.056611218,-0.06997692,-0.022725364,0.053254448,-0.0054414663,-0.014056467,-0.033299766,0.051935285,0.053253755,-0.0052217864,-0.01270223,-0.05144767,-0.0066092825,-0.12121237,0.031003539,-0.004404127,0.008647383,-0.008412539,0.0325765,-0.06719019,0.02166826,-0.045945004,0.0052969623,0.028665703,-0.055015914,0.053311996,-0.03945224,0.04453401,-0.024712455,0.03575214,0.030387139,-0.043422222,-0.008322499,-0.035032395,-0.07073903,-0.056677055,0.047941614,-0.040122744,-0.08647448,0.11899506,0.025431326 +1.3.1.97,"Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. Involved in the production of botryococcenes, which are triterpenoid hydrocarbons of isoprenoid origin produced in large amount by this alga.",384,0.99999994,-0.022043565,-0.027232904,-0.05758316,0.004551801,-0.05603384,0.048677437,-0.07642271,-0.0093005095,0.0053263525,0.033046532,0.1253414,-0.13259895,-0.061584756,-0.04906267,-0.0410921,0.020282675,0.021861317,-0.04779699,0.0010917414,0.0095077,0.07401789,0.063868254,-0.01719232,-0.03257002,-0.001904342,0.022905545,-0.054716095,0.030500462,0.0797049,-0.08375396,0.03832332,0.010323859,-0.0401302,-0.03452376,0.10976976,0.031710714,-0.017869249,-0.00085508643,0.18259577,0.113214366,0.0351865,-0.03655972,0.05753489,0.015059695,0.023657149,0.032583226,-0.08073786,0.16687198,0.0312842,-0.04516082,-0.017947402,-0.035418216,-0.000432294,-2.4756158e-05,-0.044416606,-0.10295721,0.10797945,-0.026287064,0.032417152,-0.00018092865,0.11819103,-0.022685628,0.069830894,0.033658266,-0.09636252,0.009971841,-0.028535623,-0.07406128,0.033823833,-0.038885485,-0.040855195,-0.053785972,-0.054512843,0.016988872,0.05786282,0.083944,0.027316831,-0.11295948,-0.049694996,0.0084869275,0.048217863,0.030144295,0.036462914,0.06802087,-0.04056921,-0.08437996,0.017482728,0.006763861,-0.024746154,0.06419656,-0.036691,0.0013802687,0.05573023,-0.039250016,-0.06456391,0.026122885,0.023921592,0.06445575,0.008907704,-0.02719751,0.0012584644,-0.08065264,-0.07614873,-0.12667134,-0.059386034,0.06405295,-0.0031838508,-0.012779363,0.05280832,0.001200467,-0.066968195,0.07904153,-0.08648667,-0.058282644,-0.025027076,-0.020798909,0.08120462,-0.048844602,0.043939166,-0.04622092,-0.02108808,0.010594924,0.014884053,0.0027833746,0.008865858,-0.060734566,-0.021794785,2.253084e-33,0.0029782688,-0.051216286,-0.030847643,-0.03685265,-0.011523607,-0.0007739536,-0.03409107,-0.05706866,-0.05357368,-0.06528375,-0.05470031,0.022724705,-0.022277983,0.03263214,-0.08671504,0.012896395,0.017491564,0.014823868,0.051441412,-0.08260033,0.018635781,0.036479518,-0.014956378,-0.022100886,0.088971004,0.0988972,0.028171564,-0.08957535,-0.0154453395,-0.04025324,0.06467383,-0.020892233,-0.083616406,-0.015296544,0.07074271,-0.04342668,-0.019063512,-0.023180101,-0.07923054,0.0020060495,-0.019238362,0.079862475,0.019246016,-0.06629352,0.08944741,0.018932408,-0.060297504,0.052470602,0.09947508,-0.054849837,-0.026364557,0.023451993,0.057017233,0.0462952,-0.040029313,-0.040323015,-0.026010362,-0.04346898,-0.013307574,0.020006293,0.014772745,0.14797938,-0.010016888,0.004203154,-0.018794587,-0.028924195,-0.018771008,-0.012374693,0.010958338,0.016174197,-0.03128186,0.019304546,0.031144962,-0.06721131,-0.0019210969,-0.018589696,-0.018484145,-0.02293446,-0.026325345,0.003442003,-0.03432664,-0.019389976,0.09400533,-0.09885432,-0.0581778,0.039606843,-0.0600251,-0.00020519266,0.055262484,0.08528392,-0.013088685,-0.016485777,-0.13336216,0.0362683,0.02274643,-4.1573753e-33,0.043157745,-0.012247174,0.05619832,-0.08688349,-0.008348581,0.05273932,-0.06104955,0.037969552,0.007026124,0.03774752,0.00702165,0.016661005,0.06678887,-0.03773156,0.03859248,-0.07368518,0.079560794,0.061838284,0.007564898,-0.0043601175,-0.045353156,0.03807879,-0.001945477,0.00825302,0.04831755,-0.008416107,-0.022232091,0.047026813,0.021074532,-0.0017922004,0.027520033,0.043232452,0.012092881,-0.013168679,-0.02190079,0.029951245,-0.11675117,0.0385419,0.0071897265,0.020390708,-0.01005043,-0.02837259,-0.092351794,0.013373531,0.04792957,0.053351495,-0.06289348,0.0423122,0.0065112244,0.07268113,0.054549918,0.045729935,0.024156863,0.0034913553,0.053110532,0.03564575,-0.017281266,0.01230751,0.075962484,0.016820591,0.05599187,-0.04452505,-0.021499494,-0.080243714,0.043306634,0.06712127,-0.042749345,0.017171709,0.03258848,-0.037715733,0.09912671,0.12638542,-0.08341918,-0.057472866,0.013770253,0.02840061,-0.023291333,-0.12823395,-0.033265706,0.0012971591,-0.0031874757,-0.0052527227,0.10130337,0.025189217,0.022082698,-0.021201875,0.02652115,-0.013380549,-0.042580042,0.07352036,-0.034896314,0.02221604,-0.08654469,0.025312265,0.00729377,-3.0907163e-08,-0.001099391,0.05292542,0.0751764,0.04699472,-0.06458904,0.013391638,0.009212354,-0.0021359553,0.020498414,0.006221533,0.02718753,-0.018836536,0.06973496,0.0044415505,0.08266105,-0.044287104,-0.06952895,-0.028945467,0.0276065,0.02220718,-0.0065204874,-0.07290086,-0.02189338,0.0022863224,-0.05955304,-0.06632009,0.0594458,-0.0076980977,0.0027428907,0.010348743,0.037726726,0.0114036575,-0.0051944912,-0.024027426,0.021025328,0.05352189,-0.09627149,-0.00036181152,-0.006729428,-0.03277742,-0.04404309,0.0025731549,-0.049801037,0.012388082,-0.060905676,-0.013400798,0.009010076,-0.02671945,0.013044339,-0.013322649,0.003017554,-0.060617257,0.03658079,0.036021702,-0.026885131,-0.01822653,-0.0005713285,-0.026075115,-0.032695726,0.031827528,-0.0012864731,-0.07871967,0.12665386,0.056248296 +1.3.7.10,A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. ,384,0.99999994,-0.054203473,0.0011682438,-0.10804101,-0.009805684,0.037064455,0.062018726,0.0080114035,0.113965206,0.060788423,-0.03380414,0.0053472165,-0.062369615,-0.038780294,0.067208655,-0.032653008,-0.043285877,-0.00418555,-0.00038302952,0.04145025,-0.0823464,0.006282742,0.13333362,0.0048684888,-0.015460868,0.012702114,0.028167214,0.038009487,0.02187854,-0.067003444,-0.06935044,0.007157426,-0.07223469,0.0802941,-0.030499995,0.09324424,0.12857121,-0.0737399,-0.07833348,0.096262485,-0.057719238,0.058209226,-0.016862102,-0.024319027,0.044834357,-0.05006264,0.07062379,0.03490848,0.105303295,0.037828207,-0.018553652,-0.029494744,-0.07422017,-0.08499565,0.09057941,-0.0020957764,0.031241393,0.0673903,0.031680483,-0.005440304,-0.046299513,0.040306605,-0.008768879,0.042978115,-0.020152343,-0.094271906,-0.012892964,0.013506538,-0.009838399,0.01033336,-0.03171094,-0.012576973,0.018240977,-0.0002916211,0.0898596,-0.03889632,0.10164198,-0.040280808,-0.015017015,-0.013403741,0.019480728,0.07865716,0.024408873,0.009032835,0.111440204,0.018777825,-0.04489006,0.0019519241,0.06536743,-0.006700488,-0.05822135,0.018744878,0.04205047,-0.02684558,-0.048411615,-0.0938797,0.024198001,-0.053847898,0.009915502,0.007197967,-0.0019716856,-0.01841473,0.010986505,0.06263422,-0.043642323,-0.045454033,-0.020451384,-0.023596758,0.033859555,0.07175842,-0.07325542,-0.008053756,-0.016029675,0.0117606595,-0.08107625,0.0335933,0.04286754,0.063072994,-0.031593103,-0.0299736,-0.08262217,-0.056324255,0.00019576309,0.088516936,-0.0019467865,-0.056506045,-0.006672345,-0.11324645,2.247517e-33,0.016162477,-0.004930116,0.077472925,-0.0112310415,0.033249673,-0.02732555,-0.07240915,0.017588034,0.003786936,0.0016981029,-0.05724118,-0.11704842,0.037197586,-0.056424424,0.0438648,-0.026887102,-0.052488253,0.06692569,0.03258712,-0.0057541872,-0.05002352,0.066176675,0.0012225326,0.025134286,0.038797494,0.06649015,-0.002731837,-0.04782079,0.10721821,-0.033673953,0.0033269152,-0.05821166,-0.06444926,-0.07673714,0.04375204,-0.013003653,-0.057842474,-0.016924283,0.0066856043,-0.0253677,0.023422394,0.034716908,0.06547335,-0.03382982,0.036952123,-0.043055274,-0.0826748,0.021246796,0.035816845,0.026913688,0.043139063,-0.061111547,0.12112647,0.021307616,-0.067850254,-0.01344182,0.014952475,0.11988805,0.05774225,0.033805627,0.117901094,0.043830823,-0.041925725,0.019917833,0.009311804,0.056717355,-0.063503824,0.022435132,0.013673196,0.058975887,-0.018748846,0.015529207,0.032029323,-0.086630106,-0.01490365,-0.036221012,-0.04951187,0.003965508,0.028947674,-0.0017738234,-0.045186196,-0.025388544,-0.045608725,-0.027125603,-0.07046623,0.07297406,0.041159328,0.02836113,0.03377767,0.048289157,0.027359761,-0.049030617,-0.08379304,0.068662785,-0.029735526,-1.5236845e-33,0.12674949,-0.0874505,0.043104835,-0.03560989,-0.045050833,0.08554749,-0.02479674,0.03014442,-0.08691419,-0.036278784,0.102044486,0.012117879,-0.0135555845,-0.032163672,0.029364567,0.0070502227,-0.036852386,0.019169023,-0.008148157,0.06530214,0.016673833,0.0076103676,0.026817283,-0.02880838,0.027326677,0.037793346,0.015479853,0.018308103,0.030835973,0.009875011,0.0011779477,0.02712019,-0.06715541,-0.10356012,-0.11177341,-0.004686388,0.016066859,-0.042233292,0.06201018,-0.017652048,0.02569616,0.081150316,0.01791774,0.10745076,0.039209522,0.13098593,-0.027210701,0.0017663155,-0.06033065,0.015777078,-0.019306906,-0.03362567,-0.06816324,-0.012499798,-0.06606214,-0.032476734,-0.022552462,0.062019568,-0.056450095,-0.064269595,-0.018292867,-0.055560008,-0.008286816,0.05440103,0.05590723,0.073033236,-0.06887125,0.04073929,0.06218939,-0.024101112,-0.004479034,-0.01426652,-0.024605516,0.045693446,0.043494634,0.010593639,0.007353342,0.007018476,0.06668279,0.028236773,-0.00976759,-0.030993572,-0.044436675,-0.040833518,0.02935899,-0.04778286,-0.0013496238,0.05353908,0.014541349,0.055290364,-0.06629625,0.046635106,9.399274e-05,0.07171046,0.044481706,-2.9111783e-08,0.003373411,-0.058108114,0.013927142,-0.018855626,0.010856596,-0.04488507,0.011862699,0.023060761,0.050075542,-0.0054651294,-0.031097189,-0.061121464,-0.06110001,-0.022797825,-0.023879698,0.031164384,-0.070198484,-0.00852121,0.028721996,-0.012290123,-0.063105695,0.02292803,0.00081662525,0.044303216,0.037963632,-0.05810028,-0.010152932,-0.06290158,0.0044708676,-0.013565945,0.010026404,0.053273406,-0.047246423,-0.023421327,0.058071833,0.027700802,-0.11108233,-0.0180256,-0.013938346,0.031471968,0.0071811876,-0.040922146,-0.083467655,-0.04454533,-0.05427714,0.04695781,0.019454814,0.05465912,-0.07687959,-0.06046245,0.021410817,0.0051193703,0.014821073,-0.02538474,-0.14936239,0.023004986,0.05618888,-0.03497926,-0.06430778,-0.054948796,-0.006712553,-0.061517816,0.1631178,0.012389282 +1.4.1.24,"The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.",384,1.0,-0.09852801,0.012798494,-0.04663275,-0.054889828,0.04214409,0.016231207,-0.13657822,0.0212822,0.042345136,-0.041513585,-0.0012052477,-0.015485802,-0.077617444,-0.048117634,-0.043031737,0.09783364,-0.11011216,0.062335674,-0.0076841577,-0.01421997,0.045966342,0.061210707,-0.029597215,0.008466122,0.09871726,0.0044759177,0.030310491,0.01661377,-0.041102856,0.028700992,0.07662651,-0.03589215,-0.001989419,-0.06295658,0.04662874,0.09051485,-0.0443825,-0.064513445,0.09767173,0.034711543,0.07936491,-0.0032067208,0.0015384511,-0.04983293,0.006396035,0.033837475,-0.047076233,0.061411675,0.07778807,-0.040358983,-0.062241662,-0.05460227,-0.044354722,0.03106998,0.060617696,0.06676542,-0.025414567,0.034959484,-0.04422785,0.012586139,0.03527501,0.050181214,-0.039764203,0.026851058,0.0019933512,-0.037864164,0.021651413,-0.12337006,0.09781203,-0.05080654,-0.01569568,-0.061902218,-0.034086283,-0.044539854,-0.046557013,0.047641836,-0.066700704,-0.035107847,-0.02779769,-0.0981118,0.054811373,-0.005721208,0.04375039,0.07256745,0.04093177,-0.014803911,-0.026136002,-0.031960536,0.060766507,0.015756661,-0.0019601402,-0.023001803,-0.042838197,-0.05304992,-0.054506693,0.0059520113,0.1137408,0.049558334,0.0075092586,0.06198229,0.040831387,0.08607195,-0.043365367,-0.13813613,-0.070631616,0.040573284,-0.014930571,0.01852826,-0.053540874,0.022432474,0.015185447,-0.031233126,0.038414,-0.001766913,-0.05079204,0.08803818,0.09184726,-0.035978332,-0.0885464,-0.023053862,-0.04277895,-0.03663406,0.12033807,0.011277684,-0.052433893,0.022884471,-0.037280604,7.528352e-34,0.035417266,-0.016860338,-0.0048714476,-0.062336214,0.050545663,-0.038477913,-0.07798583,0.06738133,-0.06014695,-0.057546627,-0.03889321,-0.047752332,0.040293217,-0.034719624,-0.038496412,0.010054382,0.037009154,-0.035282668,0.03921898,0.01500119,0.001246766,-0.0027548012,-0.012287461,0.021324132,0.0019039107,0.018271802,0.03742906,0.009364459,-0.0076684523,0.01200584,-0.012698234,-0.12124517,-0.0736939,-0.0460699,0.024835484,-0.00055940443,-0.10888008,-0.063972175,-0.003817954,0.012222151,-0.015734954,-0.012365056,0.008087394,-0.069178626,0.03217103,0.08869052,-0.0026094166,0.08539831,0.026749348,-0.010227887,0.051320653,0.00016644811,0.07616305,0.010900526,-0.10475146,-0.051190455,0.00065073837,-0.04299005,0.052942198,0.050983306,-0.06894085,0.027720897,-0.028378496,0.056088116,-0.006698415,-0.042786222,-0.06539049,0.0043305857,-0.007046035,0.060143586,-0.024175452,-0.035733066,0.011769561,0.025598038,0.015031342,-0.011814682,-0.03335428,0.004113892,0.04591636,-0.028779762,0.0152786765,0.04594111,0.034720764,0.02809173,-0.011435302,0.014543573,-0.035193574,0.02680559,-0.06360782,0.06209477,0.0329045,-0.037073784,-0.04363057,0.008152886,0.050609905,-2.4146515e-33,0.03711507,-0.055765703,-0.04720051,-0.09909781,-0.035001677,0.0592482,-0.034798026,-0.0041148486,0.048292052,-0.03541196,0.06708784,0.010322925,0.046151355,-0.058214206,0.05500268,-0.0489756,-0.005975996,0.12012099,-0.023901999,0.039054647,0.14512919,0.08793365,-0.02403015,-0.05187398,0.021022812,-0.013777663,-0.014155007,0.068947546,0.014967403,0.1026666,-0.0057375156,0.040558368,-0.026734618,-0.046439774,-0.021054553,0.0689201,-0.049645998,0.0062064053,0.024876794,0.070193656,0.012413417,0.049518365,-0.008258789,0.03653437,0.09860201,0.06340699,-0.08491755,0.03820385,-0.044461243,-0.04619575,0.07669652,-0.023658605,0.019382348,-0.0066400385,0.049495477,0.053879928,0.01501285,-0.012923062,0.025198936,-0.027467225,-0.05166103,-0.0471388,0.045063965,-0.010298767,-0.0064483103,0.059202474,-0.013576146,0.080843784,0.0012077144,-0.04868915,0.046809096,0.04854694,0.0034736833,0.10606434,-0.040606942,-0.051665105,-0.06862161,0.00033019867,0.0094098495,0.00022016845,-0.031045683,-0.04064719,0.051095366,-0.02223385,-0.037364725,-0.09396594,0.05323255,0.06047201,-0.073557295,0.021785952,0.0023517765,0.022679163,-0.071292296,0.08979044,0.04335858,-3.5531517e-08,0.028161243,-0.030093607,0.053418778,-0.0020300664,-0.018937865,-0.003355792,0.05719547,0.06844233,0.037013404,-0.03895964,0.06325964,0.03997515,0.008416799,0.017391076,-0.02412038,0.04350988,-0.012966935,0.0022228016,-0.065752745,-0.013235097,0.022179812,0.008322195,-0.08669111,-0.02727936,0.015070919,-0.073119044,0.02433,0.045934103,-0.033448163,-0.036317736,-0.009029015,0.024318358,-0.0066743074,-0.047880225,-0.06952648,-0.043284703,-0.04818617,-0.07459243,0.025213687,-0.09558835,-0.023677101,0.005974506,-0.05526398,0.04892981,0.0030367696,-0.027019722,0.02572958,0.023650208,-0.020220181,0.04713132,0.07025761,-0.016035503,0.11550096,-0.07097008,-0.11824007,-0.022414992,-0.0073849545,-0.03384177,-0.10604383,-0.101324245,0.034073897,-0.0113166245,0.1730672,0.02191052 +1.5.1.43,"The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3].",384,0.99999994,0.010713023,-0.03795004,-0.090219185,-0.042657483,0.1115289,0.06457985,-0.0598159,0.02414823,0.044417474,0.049167104,-0.031928685,-0.05160863,0.0022400124,0.109519504,-0.03303094,0.004007255,-0.060691774,-0.020582529,-0.0016454337,0.03799183,0.030000383,0.016747734,0.013472112,-0.013104245,-0.019254966,-0.015313754,0.072117865,-0.022305923,-0.045122672,0.02762212,-0.047701057,-0.03218624,0.014623962,-0.11623229,0.11723281,0.014186443,-0.057200953,-0.009491792,0.1265847,0.07354747,-0.014255157,0.043054033,-0.012365156,-0.081129655,0.002772133,-0.01180836,0.06634063,0.03985051,0.07513813,-0.07239031,-0.05955581,0.026382253,-0.0028584313,-0.01443541,0.010641094,0.020374445,-0.04568263,-0.060956854,-0.05164694,0.02344058,0.014174125,0.0015671181,0.038533956,-0.06939648,0.0028499921,-0.0669782,0.018203035,0.0043180073,0.07275684,-0.014708428,-0.06937317,-0.022295665,0.038888983,0.058984727,0.010776401,-0.029604882,0.04434385,0.040567584,0.033948448,0.014088592,-0.029896656,-0.07660454,0.05656079,0.041555915,-0.011597979,0.015474104,0.039330453,0.05976664,0.07562185,0.04491476,0.01003389,-0.051514294,-0.0022495945,-0.09102642,-0.07539821,-0.08965975,0.020804947,-0.006958881,0.07616008,-0.045123063,-0.04105233,-0.039925702,-0.02213122,-0.089913666,0.0039598816,-0.015742693,0.032329466,0.12588523,0.027431762,0.04280752,-0.017203096,0.051472705,0.047028854,0.021972729,-0.0916097,0.100711,-0.012448155,-0.06969446,-0.087489195,0.028092112,0.095366634,-0.08472046,0.05924063,0.05620843,-0.014381953,-0.03617853,-0.05910941,4.2996538e-33,0.019349772,0.07117973,0.038535703,-0.047615595,0.09722333,0.031942725,-0.044154715,0.025673896,0.027898656,-0.089468956,-0.08024278,-0.13075781,0.071153715,0.026233735,-0.05338292,-0.029357474,-0.15144624,-0.043531727,0.011773897,-0.015028165,0.003834548,0.08717239,-0.0107791675,0.046995353,-0.027198827,-0.015265179,-0.047404584,0.0033167058,0.03210231,-0.008572422,0.010574915,-0.04250853,-0.09540457,-0.025149778,0.084131755,0.027161019,-0.074381486,-0.052710228,-0.055563293,0.052249253,0.0010216954,0.06552487,-0.03809724,-0.004033528,0.00950904,-0.05726152,-0.06032606,0.114735164,0.02436613,0.0561042,0.0247481,-0.0040564258,0.03228574,-0.030732382,-0.08242561,0.046955913,0.006437406,-0.07278352,0.028915789,0.03799984,0.037147388,0.031681895,-0.044870164,0.0037575576,-0.03478651,-0.0037978278,-0.00894379,-0.07659593,0.07266755,-0.0004342606,-0.046080902,-0.0080743255,-0.016863637,0.055172827,-0.018889684,-0.010277156,-0.086168736,0.016197005,0.033004392,-0.053255238,-0.04748737,0.00682927,-0.0058954535,0.022964874,-0.039687138,-0.028776592,0.025408356,-0.0334505,0.0037793447,0.017361812,0.011547975,-0.120473534,0.010815767,0.00990172,0.020732395,-6.2915044e-33,0.031755865,-0.07471044,0.04255341,-0.05438815,-0.034296904,0.044706058,0.040570993,-0.058293685,0.013878572,-0.026628222,-0.009527493,0.012711722,0.033046495,0.052642982,-0.030082008,0.05358371,0.053796764,0.047865257,-0.054756947,-0.029356528,0.0340482,0.00583986,0.047736775,-0.026614333,0.014978065,-0.009961152,0.02236118,0.042385444,-0.012409338,0.04667878,0.035346385,-0.0012475257,-0.067390405,-0.07583565,0.010432503,0.04429672,-0.06325099,-0.036871124,0.04767045,0.0065644872,0.041014716,0.00014102108,-0.020343175,0.0952443,-0.03276036,0.02835854,-0.10252191,0.031035475,-0.0073255226,-0.016940711,-0.027548317,-0.036837135,-0.015533322,-0.051358663,0.011262749,0.027971422,0.05624586,-0.045045033,-0.031396687,0.018396273,-0.020739572,0.009794468,-0.020196289,-0.010537739,0.04157486,-0.025244724,0.024547804,0.111471854,0.08845543,-0.1002942,0.07268778,0.016466342,0.08482585,0.10215304,-0.06956907,-0.050705496,-0.07013021,-0.048813686,0.045445774,0.016323451,-0.034688678,-0.016684022,0.036784768,-0.043251544,-0.05397701,-0.046338487,0.05468706,0.08719899,0.028837213,-0.002917209,0.039224744,-0.053236954,0.09714494,0.08379233,0.045683187,-4.4974644e-08,0.02215144,-0.08558667,0.035495505,-0.005991593,-0.037410755,0.012128025,-0.031158226,0.014316336,0.030372607,-0.05226718,0.017431697,0.044272393,-0.038475167,0.005471476,0.017898345,0.0501407,-0.06387437,0.061222866,-0.059641857,-0.035745453,-0.09690713,-0.0008234977,-0.12634003,0.02191621,0.06382634,-0.052782003,-0.03660072,0.02997937,-0.0696472,-0.055751283,0.0031850818,0.021142669,-0.021801868,-0.04215995,-0.107960664,0.007298738,-0.019557862,-0.0206064,0.02341384,-0.011140935,0.08067475,-0.030339822,-0.07459224,0.008797819,0.067407496,0.007325531,-0.037662342,0.008428867,-0.020038454,-0.04448485,0.052389037,0.019273,0.028845407,0.026469596,-0.053743035,0.01765494,-0.078053705,-0.02613988,0.04801175,-0.041223865,-0.0364802,0.1048988,0.1819946,-0.019042049 +1.5.1.44,"The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The reaction proceeds in vivo in the opposite direction to the one shown here.",384,1.0,-0.040988818,0.028846847,-0.17866158,0.010297103,-0.0124578215,0.008240354,-0.07078069,0.045610365,0.05412781,0.003324444,0.04169928,-0.17192934,-0.08946792,-0.015099971,-0.10403603,0.010675705,-0.07172132,0.029026674,-0.017979123,-0.051863607,-0.012265777,0.008594344,0.067109466,0.020435778,-0.019644957,-0.03029158,-0.052250225,0.018391797,-0.017578516,-0.10965968,-0.01742224,-0.0016028,0.057328057,0.012133448,0.005684767,0.05765283,-0.09264561,-0.06499128,0.0945397,0.0022711682,-0.053559612,-0.013314633,-0.043290883,0.024301914,-0.025274418,0.019943936,-0.018345453,0.10153937,0.04220586,0.08069529,0.0073702717,0.010911512,-0.06772068,0.019644963,0.043012053,0.007857272,0.0049832594,-0.0031964367,-0.05138574,0.086791,0.125697,0.06416472,-0.111759946,0.03532707,-0.095226444,-0.05573022,0.031888437,-0.079742394,0.0037938175,-0.06384954,0.0053491667,-0.094665594,-0.001283332,-0.030818434,0.05741044,0.12607634,0.033649832,-0.006661092,-0.053546455,-0.029369274,0.11190177,0.027558481,0.07717372,0.05363174,0.017902708,-0.036437903,-0.029817244,0.019600024,0.046270348,0.05152148,0.09978219,-0.0072439057,0.008179782,-0.03072839,-0.038178682,0.072633974,0.0014167624,0.045047242,-0.003108882,-0.015887402,-0.0071319304,-0.03509309,0.040114187,-0.044372488,0.009643112,-0.0053095003,-0.015924059,0.055657297,0.048155475,-0.057817414,-0.029963894,0.031773925,0.060082275,-0.023691215,-0.06080649,0.13564508,0.07099009,-0.053156313,-0.046455305,0.055039972,-0.004162755,0.0012091335,0.019349318,0.05800058,0.006582426,-0.091238014,-0.0707001,9.6399785e-34,0.044750754,0.060835615,-0.055339824,-0.0068802414,-0.006818619,-0.022706937,0.028449211,-0.07211965,-0.107347965,-0.020382186,-0.064341106,-0.033822395,0.01689544,0.070100784,-0.06829848,0.033916518,-0.013622633,-0.046531845,0.021378746,-0.044894833,-0.0056921435,0.010452505,-0.075268514,-0.046373162,0.015475273,0.10263069,-0.02714003,0.08162928,0.008529683,-0.012769156,-0.043794233,-0.06975537,-0.04323372,0.029251708,0.082705826,0.042750858,-0.032370534,-0.047969323,-0.012221966,0.04221603,0.011015689,0.05846203,-0.04688489,-0.028747633,0.04451188,-0.0020238517,-0.03754239,0.11969411,0.07228855,0.071866795,0.051914793,-0.019643227,0.094965965,0.03796451,-0.07410733,0.0450297,0.004724248,-0.02449768,0.011007552,0.052078653,-0.03852123,0.041999705,0.009762165,0.06020401,0.0026226384,-0.036569666,-0.04559901,-0.096413955,0.021332389,0.07726163,-0.036125574,-0.05985715,0.038824238,-0.02998364,-0.007779591,0.024533335,-0.09620296,-0.051278852,-0.04919822,-0.030058311,0.010481545,-0.05509909,0.0053763683,-0.03868306,-0.04556193,-0.01734316,-0.067208596,-0.053471148,-0.024125412,0.049189862,-0.0042180023,-0.012550549,-0.036571234,0.0015176972,0.067276634,-2.2835311e-33,0.037715975,-0.059100408,-0.019354103,-0.040608637,-0.037956342,0.052014295,-0.039536793,-0.04421829,-0.029999586,0.054459173,0.069674745,-0.048885528,0.04148682,0.004731379,-0.026579881,-0.013019578,0.09523867,0.09198275,-0.0019808647,0.046193503,-0.04151604,0.03563085,-0.019515328,0.029856022,-0.0037548325,0.028519146,0.012124564,-0.0063795648,-0.017737878,0.046110615,-0.058859732,0.008305837,-0.016592836,-0.037274357,0.052349422,0.0204564,0.038742203,0.007023427,0.03725377,-0.0049745105,0.031847406,0.07138767,0.059295967,0.044373922,0.07443624,0.051923335,-0.0080719665,0.0129359495,-0.026904931,-0.04781184,0.04611787,0.010250994,0.018278806,0.068069905,0.0013710298,0.020267265,0.07166654,-0.07747368,-0.018208897,0.006831011,-0.059509538,-0.09653703,-0.0020777732,-0.07563995,0.03711702,0.07407914,-0.023156328,0.07116387,0.08635009,5.042089e-05,0.0670164,0.032578256,-0.03350925,0.023183243,-0.15946962,-0.015090734,0.002962158,-0.049958665,0.04366219,-0.0064937784,0.036672488,0.0052164574,0.077732176,-0.052322324,-0.011611478,-0.114613645,0.018087793,0.067790404,-0.03280908,0.0395141,0.012764552,0.012365484,-0.04900844,0.017725075,0.05986887,-3.350545e-08,0.039812542,-0.055341512,-0.01667696,0.013358733,0.010255623,0.026423076,0.020639002,-0.02192086,-0.039505072,0.007302361,-0.05579159,0.08881013,-0.0027987265,0.062001273,0.08470693,0.049868323,-0.014652875,0.0537403,-0.005249451,0.024436317,-0.0025917387,0.020158814,-0.042246435,-0.014802096,-0.021486387,-0.044501215,-0.017618904,-0.00855307,0.05548179,0.033167586,0.03356194,0.02853786,-0.05139175,-0.047804594,-0.060924325,-0.039261114,-0.009795582,-0.07661261,-0.044849884,-0.0008553259,0.003455465,0.075340524,-0.05457099,0.021234468,-0.065616645,-0.05711133,0.016156415,0.0015467568,0.040267393,0.013126006,0.05778276,-0.028943885,-0.011151385,-0.025643492,-0.09829991,-0.03445474,-0.012618237,0.0210814,-0.008061446,-0.052385565,-0.017977413,0.0033676561,0.17331707,-0.036349706 +1.5.1.45,"This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and EC 1.14.14.8, anthranilate 3-monooxygenase (FAD). It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor. cf. EC 1.5.1.37, FAD reductase (NADH).",384,1.0,-0.05900936,0.014143876,-0.12387783,-0.017494166,0.09965641,0.006666277,-0.049704272,0.060606327,0.054571267,-0.018837584,-0.040433906,-0.026292022,-0.06445731,0.073647715,-0.094474845,0.01743299,-0.08825452,-0.047091644,0.05197343,-0.023496592,-0.002191977,0.087080784,0.008733875,-0.01589676,0.010358109,-0.036584876,0.017522585,-0.0391587,-0.05615254,0.013994966,0.0075014723,-0.0356756,0.026129292,-0.020764988,0.022961698,0.15507336,-0.0076923724,0.020186411,0.032076325,0.037616327,-0.019884555,-0.013195523,-0.0035352067,-0.030744383,-0.025444977,0.058118034,-0.00086512393,0.05109758,0.031178154,-0.005832077,-0.04703908,-0.0411424,-0.05115925,0.057584126,0.10924298,-0.005704917,-0.018412497,-0.06938365,-0.03812399,0.019401548,0.021999309,-0.029639298,-0.027141904,-0.0029339415,0.097243816,-0.05839294,0.024557834,-0.0940488,-0.014031882,-0.043467082,-0.06390467,0.005541296,-0.033135563,-0.021260785,-0.02729508,0.026241286,-0.05334247,-0.041365523,0.07709429,-0.0027362236,0.05141192,0.043006178,0.055642165,0.08298721,0.02690154,-0.021582667,-0.02671412,0.04160143,0.00595333,0.040867485,0.031134915,0.02309818,0.011155343,-0.007978239,-0.074143015,0.011547173,0.040011894,-0.015779126,0.0025803852,-0.020214694,-0.029217998,0.014437347,-0.0033612063,-0.060281973,-0.09436212,-0.026520241,0.003792689,0.1274801,0.056355823,-0.022680346,-0.03508019,0.009139303,0.032649126,-0.017982274,-0.06457255,0.07949232,-0.024909578,-0.100995876,-0.07668355,0.026013324,-0.05367941,0.04166131,0.046837457,0.11457383,0.01581154,0.010305944,-0.10565338,3.637687e-33,0.088413864,0.00491408,-0.026932456,-0.024353964,0.0060081137,0.048672795,-0.0767005,-0.010820851,0.00010413472,-0.047165375,-0.024091339,-0.106047526,0.037917066,0.0040478357,0.011982698,0.018046606,-0.08882734,-0.03551731,-0.00883352,-0.026429754,0.041807782,0.04359031,-0.007620723,0.03668295,0.026796216,0.04767946,-0.049220428,0.07075799,0.015390978,-0.008787878,0.04058064,-0.09234055,-0.14989509,0.016091803,0.036965508,-0.0018121488,-0.07939351,-0.02908303,-0.0786455,0.08414552,-0.0046487716,0.056153778,-0.01324996,0.0016433276,0.12540181,-0.039923016,-0.010922816,0.15125701,0.031508133,0.09734918,0.055013906,-0.01439087,0.048171937,-0.044811446,-0.07190541,0.013407314,-0.028410638,-0.019360645,0.021125583,0.032289624,0.022007115,0.022665348,-0.0103790825,0.0718449,-0.028468201,0.014300723,-0.0092961965,-0.10028483,0.022789314,0.09798006,-0.011395898,0.025908347,0.09435532,0.02818655,-0.007704788,-0.071165666,0.009854913,-0.035128918,0.008580614,-0.011928964,0.013209562,-0.047500227,0.0041578365,-0.06975217,-0.042831317,0.006800255,0.014789625,-0.121921174,-0.018830871,0.033461183,0.03231955,-0.10268198,-0.10478523,0.018110594,0.034852777,-3.88088e-33,0.07198818,-0.098933056,0.058620322,-0.09900313,-0.056202114,0.08440971,0.02847234,0.01573808,0.031521283,-0.051867574,0.063249096,0.004809312,0.08114864,0.0039143073,0.043625906,-0.009866685,-0.029605271,0.04467007,0.019260611,0.02308026,0.009518672,0.08489318,-0.011937841,-0.03714373,0.025158772,0.010717152,-0.09333361,0.075584866,0.04345437,0.01714347,-0.015503483,0.03504702,-0.115455404,-0.03472658,-0.0031298092,0.055299826,-0.0833709,0.0050751255,0.026316172,0.017717991,0.029492,0.02619193,-0.00095334655,0.042460404,0.005654089,0.115506634,-0.10853938,0.0071199522,0.05427471,-0.09370911,0.00022095378,-0.0076099457,0.0020586008,0.029419618,0.056752287,0.03485789,-0.013231708,0.061814997,-0.032579705,-0.037372366,-0.0091901645,-0.08146696,0.071978815,0.026334915,0.06694274,0.03721891,0.0125043895,0.047388177,0.058683675,0.079296105,0.091318,-0.0059501673,0.041373167,0.030955277,-0.03235525,-0.04846753,-0.06455172,0.036291797,-0.018220663,0.026086573,0.05505897,0.049493246,0.012604365,-0.0077655604,0.003133227,-0.05636236,0.03806704,0.08752338,-0.018307563,0.03391778,-0.0062257997,0.038721353,-0.010388734,-0.00049460895,0.03145758,-4.279833e-08,0.049413435,-0.08487124,0.021581937,-0.08559038,0.028963426,0.035587225,0.028468773,0.022485632,-0.027640607,-0.037095826,-0.0131054185,0.09025946,-0.00513464,-0.016741348,0.03519817,-0.050633334,-0.046077076,-0.0055870237,-0.02779515,-0.026729604,-0.12650704,-0.004956508,-0.040050704,0.02744026,-0.024468193,-0.0017522534,0.06874516,-0.0073022097,0.013858002,-0.05685087,-0.026285054,0.040188923,0.03651352,-0.04364128,-0.14411642,0.09093388,-0.04755054,0.033614136,-0.047957055,0.02715893,0.011177725,-0.0252553,-0.017386576,0.013356417,-0.036054835,-0.034428276,0.009324294,-0.036947004,-0.02146546,-0.023147509,0.05025345,-0.0074565294,-0.03535807,-0.004046471,-0.09764152,0.009611822,-0.042674284,-0.07281517,-0.042646475,-0.05274874,0.013623079,-0.00015006414,0.1373693,0.0018265645 +1.7.2.6,"The enzymes from the nitrifying bacterium Nitrosomonas europaea [1,4] and the methylotrophic bacterium Methylococcus capsulatus [5] are hemoproteins with seven c-type hemes and one specialized P-460-type heme per subunit. The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate [3]. While nitrite is the main product, the enzyme from Nitrosomonas europaea can also produce nitric oxide by catalysing the activity of EC 1.7.2.9, hydroxylamine oxidase [2].",384,1.0,-0.03373145,-0.011586264,-0.022541882,-0.024289798,0.04830097,-0.0011056811,-0.014083975,0.0026845417,0.031955328,-0.09706909,-0.019887839,-0.07050233,-0.07516296,0.035011727,-0.067962386,0.040775545,-0.065737,-0.08298149,-0.023525218,-0.01493764,0.053516187,0.03375783,-0.056863092,-0.060392156,-0.031987336,-0.0106572835,0.029412564,-0.08449032,-0.025852202,-0.05816554,0.042125408,-0.045895834,0.023441136,-0.05513171,0.08566629,-0.003699364,-0.0131127285,-0.07316573,-0.0047529307,-0.0076390654,0.06246102,-0.042682156,-0.033541832,0.026198877,-0.025208592,0.0376835,0.09063644,0.04267763,0.0032691248,-0.022024227,-0.049580466,-0.08029058,0.0010021925,0.010745883,0.04255939,0.015315295,-0.02793641,-0.050636437,0.03288395,0.013041418,0.07469325,0.03239582,0.0006489751,-0.043574046,-0.02253146,-0.045179453,0.08472032,-0.0365433,-0.047406852,-0.101184815,-0.05403054,-0.07286708,-0.018823674,0.0309805,-0.023965837,0.04987706,0.03511139,-0.048304062,0.06739759,-0.027505107,-0.014595559,0.08092337,0.027568175,0.102098204,0.05648771,-0.0055105556,-0.0059732953,0.0394842,0.020450998,0.016028421,-0.021336399,-0.027167236,0.033977855,-0.022678912,-0.07417483,0.029937906,-0.04772431,0.040060956,0.005081024,0.0051836637,-0.0056145056,0.053147696,-0.031954817,-0.07704435,-0.115354456,0.068801194,0.021594904,0.11044041,0.08128189,0.019655451,-0.013303907,-0.014149192,-0.027058665,-0.01993535,-0.015578217,0.057727687,0.020015007,-0.040920414,-0.11854725,0.00073049933,-0.015956532,-0.022146842,0.037364077,0.010111966,-0.078484386,0.12200257,-0.07885158,5.402693e-33,0.05404,0.011729319,-0.01795179,-0.04135343,-0.026421027,0.002944524,-0.11083441,0.011456868,0.017044462,-0.058103584,-0.05671443,-0.08903278,0.02101754,-0.03254158,0.017540647,0.020989263,0.033328015,0.014491836,0.02126371,0.05186391,0.0031497781,0.06343958,-0.05689746,-0.016423982,0.030319452,0.06356978,-0.016082138,-0.06757962,0.106448695,-0.016002625,0.02812859,-0.101094894,-0.039878882,-0.011546155,0.03273132,0.033590123,-0.030464329,0.032539602,-0.05025566,0.04836818,-0.042920962,0.0963919,-0.020066468,-0.069113314,0.04776902,-0.040111683,-0.061535176,0.07507982,0.036859848,0.0019940773,-0.024105733,0.0067111077,0.09649383,-0.003095353,0.0059293886,0.043862723,0.02797862,0.039906844,0.1104917,-0.053975217,0.032957505,0.010142519,0.020316666,-0.029362796,0.06446339,0.06685303,0.013820504,0.00050759106,0.028534388,0.030208308,-0.114475176,0.07896904,0.08267625,0.011799122,0.0075502186,-0.098745055,-0.04431134,-0.015126633,0.09722824,0.0139953885,0.07952336,0.027138136,0.10167119,-0.06885763,0.01795144,-0.016495613,-0.025265854,0.03539908,-0.0022512635,0.032460492,0.07712313,-0.09759008,-0.054130998,-0.07893631,-0.033683173,-4.4236336e-33,0.096478894,-0.07894614,-0.046456583,-0.122967266,0.02883169,0.085604295,-0.050131895,-0.035043318,-0.11650086,0.00050520425,0.08586954,-0.02624541,0.026505781,-0.0053289994,0.033872943,-0.06203299,0.0043761944,0.06894666,0.008760148,0.007469033,-0.007480983,-0.013353171,-0.016835317,-0.020897461,0.021971688,0.029247623,-0.03903485,0.031906877,0.119064815,-0.0061520627,-0.035199523,0.06572709,-0.048423074,-0.08357892,0.047262855,0.05041102,-0.045256265,0.027954146,0.06240648,0.020584358,0.0080854455,0.012135306,0.06346263,0.061811592,-0.03708921,0.08431881,-0.09043073,-0.015056277,-0.022042751,-0.008615942,0.06805695,0.0315874,-0.07699501,0.025434885,0.02516838,-0.024650253,0.079914734,0.05566034,-0.020940773,-0.05815206,-0.11319645,-0.03957876,0.03106723,0.023261983,-0.008111969,0.055204034,-0.06957296,0.12795965,-0.03839669,-0.026692452,-0.018615503,0.018040584,0.10607233,-0.012011923,-0.010335599,-0.059307437,0.029514588,-0.022821056,0.031163327,-0.047338855,0.013335788,-0.032977156,0.011005491,-0.064896636,0.03507834,-0.03047406,0.07192122,0.03480822,-0.0065949652,-0.0011171716,-0.02282921,-0.012562944,-0.07729264,0.021262795,0.026493512,-4.1143153e-08,0.0007989788,-0.1159857,0.034965396,0.023967387,-0.023106301,0.05279163,-0.005227195,0.01951937,0.036509495,0.008529991,0.0996644,0.055914685,-0.015401793,-0.07900524,0.0016135864,-0.026710356,-0.005114602,-0.011673963,0.015860165,0.055046536,-0.029707618,0.07015911,-0.07413958,0.026978828,0.025161983,-0.0873642,-0.006450908,-0.044370495,0.008761341,-0.096923605,-0.029431636,0.082460515,-0.006655927,-0.021814043,-0.030412156,-0.030190146,0.012275832,0.034499113,-0.010707824,-0.01930299,0.013829536,-0.018068327,-0.11819892,-0.023709826,0.053610697,0.020288832,0.009897118,0.0026492742,-0.04079404,-0.0020771637,-0.017242618,-0.03248728,0.058000725,-0.023375817,-0.11008335,0.0647218,0.03906781,-0.03895473,-0.0456599,-0.012857138,0.036089372,-0.00070750393,0.15112011,0.059756253 +1.13.11.65,"The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects. The enzyme accepts different all-trans carotenoids, including beta-carotene, alpha-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule.",384,1.0,-0.01939284,-0.052450452,-0.06082784,0.056117073,0.028790172,0.042037264,0.004277657,-0.014826536,-1.1563541e-06,-0.0004858622,0.064714156,-0.079441674,-0.085423276,0.034750666,-0.029444875,0.062471647,-0.061727926,0.0433837,-0.019207735,-0.07098372,0.09065093,-0.06863805,-0.021640142,0.010282586,0.013869999,-0.025688486,0.04593462,-0.074018136,-0.043889582,-0.09900901,-0.06882121,-0.04682723,0.029306047,-0.007412251,-0.009709519,0.030702438,-0.026445879,-0.0772083,0.0051084952,-0.009363056,0.05237495,0.010759087,-0.07614018,0.016078448,-0.042830046,-0.028656261,0.014178661,0.10134962,0.03149305,-0.03724963,-0.0891533,-0.101269245,-0.089928634,0.01823377,-0.03886137,0.06497586,-0.044313118,-0.0082950955,0.05023562,0.027186412,0.084834225,0.026355218,0.016716823,-0.020272389,0.058314893,-0.071270384,-0.05320182,-0.07518192,0.016497023,-0.08189643,-0.010561297,-0.062264584,0.017181706,-0.048529204,-0.044936124,-0.0040821666,-0.01242278,-0.007928587,0.014208636,0.018602483,0.022848995,-0.012828747,0.020624701,0.09697057,0.1158006,0.016749708,-0.020681934,0.060731564,-0.012786787,0.048449785,-0.0010349363,-0.05763348,-0.05421888,0.01227805,-0.03140962,0.0012038207,0.040064763,-0.087431096,0.023077074,-0.039768487,-0.015801279,0.04175457,0.021926843,-0.10868378,-0.048800718,0.009073973,0.023769233,0.069121964,0.010979493,-0.011213921,0.029063094,0.06590584,0.059246954,0.047530968,-0.08480314,0.0269074,-0.06584896,-0.042953737,0.022645423,0.1095221,0.019205144,0.054924138,0.04592214,0.057873715,0.019080892,-0.017829904,-0.06519852,2.720197e-33,0.024451116,0.06334701,-0.028110048,0.031877637,0.009385174,-0.036594156,-0.019793162,0.023279075,-0.08498245,-0.04156415,-0.08754291,-0.042291403,0.056148093,0.0453152,-0.012263629,-0.009381916,-0.0052939467,0.0031794426,0.108143,-0.013114105,-0.07290771,0.022081055,-0.059581123,-0.0456779,0.012905819,0.085914284,-0.07456125,0.030447444,0.013084506,0.037064552,0.08595376,-0.011302819,-0.046321813,0.0752421,0.13203654,0.07000199,0.043112315,-0.08123371,-0.102663375,0.051035028,0.020055883,0.007379899,0.017591542,-0.03574606,0.045822736,-0.04133142,-0.0617302,0.053723473,0.06456385,0.058771245,0.012137006,-0.0019912948,0.100094415,-0.10235543,-0.056462895,0.02205491,-0.012276128,-0.019232286,-0.02816914,-0.015410388,-0.053694304,0.054263916,-0.06201673,-0.012287762,0.001663254,0.05495867,-0.07204496,-0.08823498,-0.07855361,0.020877762,-0.02773356,-0.035862602,0.02951705,0.013653186,-0.0029115577,0.036953285,-0.009037168,0.03735754,0.02970215,-0.04158018,-0.061538454,0.0106119,0.05513615,-0.061875265,-0.027074927,0.031248283,-0.016528074,-0.008796665,0.05954962,0.066131316,0.0070595825,-0.05291693,-0.018501507,-0.028747488,0.036412194,-2.7566055e-33,-0.006317586,-0.13282403,-0.0052961637,-0.039203763,-0.058417533,0.057939168,-0.07118516,-0.06245704,0.047914818,0.019696558,-0.0045912666,0.04562119,0.019842576,-0.040491723,0.02167827,0.011831085,0.06175637,0.06071322,-0.010389152,-0.028443594,-0.084258474,0.13002141,0.024701312,-0.00055933936,0.028256128,0.06282604,0.011263846,0.10474123,0.08726888,-0.022505071,0.035141896,-0.050854556,-0.017098462,-0.027564071,-0.013933853,0.06899344,-0.112608925,-0.01239755,0.09794123,0.12646075,-0.041991334,-0.016847057,0.0040465402,-0.018197527,0.07114622,0.024864126,-0.026598072,-0.011858411,-0.013033454,-0.053761102,0.04170226,-0.017780047,-0.053663876,0.012960633,-0.019429129,0.052159425,0.059015244,0.048350167,0.04376401,-0.070260204,0.0005320764,-0.08003661,0.063317426,-0.041137535,0.0069015496,0.030525027,-0.011514157,0.08026684,0.06792988,-0.0091364235,0.09678322,-0.015048824,0.031867836,0.06589502,-0.06413317,-0.051425356,0.001878134,-0.017611755,0.011474847,-0.04353409,0.028997531,0.0065062973,-0.0019440763,0.0003727525,0.018676037,-0.0167147,-0.007638413,0.0719762,-0.0022043977,-0.025265912,-0.023694424,-0.02613953,-0.041711662,0.080715,0.12377867,-3.829016e-08,0.08523331,0.004221314,-0.0054050446,-0.034986366,0.011575664,0.0028815304,-0.012936174,-0.014923702,0.017722998,-0.030225614,-0.038569007,0.030664507,0.08337883,0.020891314,0.042432066,0.032692403,0.022304576,0.019945435,-0.01840863,0.055834178,-0.10931399,0.027012244,-0.09459371,0.019576708,-0.0016547944,-0.061222136,0.04260332,0.026567617,-0.039258584,0.030009903,0.037551176,0.06562604,0.04680391,0.030216012,-0.11877697,0.016521523,0.005666097,0.0028846737,-0.013982475,0.00785263,0.0039436454,-0.04275873,-0.045475174,0.02853737,-0.057510205,-0.022126947,0.06812848,-0.033643875,-0.02635309,0.074909806,-0.04055929,0.004484548,-0.03587148,-0.044234555,-0.106666386,-0.065104604,0.05544909,-0.077534094,-0.024999194,-0.07054818,0.04824672,0.0874802,0.14542927,-0.045641325 +1.13.11.66,"The enzyme is an extradiol-type dioxygenase, and is a member of the nonheme-iron(II)-dependent dioxygenase family. It catalyses the ring cleavage of a wide range of hydroquinone substrates to produce the corresponding 4-hydroxymuconic semialdehydes.",384,1.0,-0.044798773,-0.036939573,-0.042434815,0.035181828,0.09202585,-0.005233775,-0.05535377,-0.0126786735,-0.020142736,-0.10345529,0.0055271154,-0.062276196,-0.03502268,-0.011015485,-0.027171392,0.056172915,-0.07576954,-0.031237185,-0.03363515,-0.022295281,-0.032275695,0.012803459,0.014714423,0.06537421,0.05646352,-0.0012268494,0.047647633,0.052504446,-0.075292654,0.0016449364,0.061297666,0.0065674433,0.015110005,-0.03406815,-0.041798316,0.07292104,-0.023962082,0.022018949,0.04652859,0.015312721,0.0032458103,-0.026799904,-0.036035378,-0.026629182,-0.019354431,-0.049755085,-0.025877567,0.032320302,0.04187152,0.0998728,-0.0017878771,-0.017267976,-0.066444166,0.07601994,0.047648642,0.012267718,-0.041331615,0.034330413,-0.051573638,0.033677753,0.04443116,-0.0040132543,-0.06065703,0.04207484,-0.02108386,-0.02539498,-0.0081302235,-0.059394043,0.0078926105,-0.09943703,-0.026908794,-0.09950106,-0.038087107,-0.030270195,0.008706158,0.013071756,-0.020238869,-0.023546671,0.10627153,-0.047211397,0.010667092,0.0050937156,0.09186962,0.12567872,0.058523417,-0.0013900582,0.049024273,-0.0558132,0.037925404,0.043974683,-0.03190923,-0.038105875,-0.030883677,0.0015561469,0.038846444,0.038060434,0.047395132,0.07014208,0.022130413,0.02368844,0.0033189382,0.0060674883,-0.039102092,-0.12495676,-0.052720938,0.015658353,-0.044264026,0.09934871,0.0004427924,-0.071693435,0.021361612,0.004980625,0.03837731,-0.016783532,0.017132275,0.10164253,0.047752995,-0.042096365,-0.07565808,-0.01951872,0.019102918,0.009958867,0.092589125,0.008985234,-0.066534,0.04258294,-0.07268883,2.1083584e-34,0.024748947,0.022950837,-0.0012221056,-0.021725006,-0.021641864,0.03859296,-0.11539937,0.043725763,-0.12577286,-0.027334582,-0.03647072,0.0077902507,0.032450974,0.02667804,-1.4035555e-05,-0.049796205,0.0041876608,-0.029574623,0.046246924,0.039758284,-0.0026194137,0.0861333,-0.052497927,0.00264749,-0.041137822,0.08110623,-0.016217824,0.016205095,0.02957349,0.04359393,0.026788207,-0.09168214,-0.06098882,-0.04773129,0.0122252805,-0.0063968874,-0.06157839,-0.04561504,-0.013609862,0.041390315,-0.0027077175,0.017455751,0.007714736,-0.09929745,0.014050937,-0.06441768,0.03791083,0.11150596,0.0036906647,0.07572901,0.00010659727,0.016437594,0.09058289,-0.017810795,-0.06378988,0.034590688,0.019199535,0.015909394,0.08625423,0.053685546,0.0007605274,0.029258026,-0.017411523,0.06847837,0.0012480203,-0.047348607,-0.02474304,0.0010292876,0.0035083415,0.07343762,-0.019053057,0.036674485,0.052900117,0.016098222,0.05011791,-0.052896496,-0.05987568,-0.007758315,0.06188153,0.0028822606,-0.06024451,0.022797085,0.080816954,-0.030639278,-0.06774482,0.0074232365,-0.060317095,-0.006672052,-0.036586232,0.037009284,0.02352989,-0.03678688,-0.08909105,-0.05878387,0.072279386,-1.5076916e-33,0.08528588,-0.099935636,-0.066087715,-0.09333143,-0.0160117,0.023085091,0.05999067,-0.0276228,0.024588566,0.054068938,0.075173,-0.029895762,0.0047769574,-0.062437188,0.069337614,-0.0063347905,-0.059676204,0.03859857,0.02214442,-0.026508449,0.1233703,0.041659217,0.009342927,0.0054068533,0.018994566,0.011112713,-0.080936305,0.032667503,0.0666832,0.1097598,-0.113191456,-0.015458958,0.014258644,-0.031344824,0.06752559,0.061791513,-0.044266608,-0.0049195895,-0.015164178,0.007760109,-0.009729675,0.01228064,-0.008455602,0.0693039,0.058781862,0.09788114,-0.12130253,0.12225471,0.012077004,-0.0033415619,0.0027782111,0.0025159556,-0.024875674,0.048052587,0.01309941,0.008900347,-0.02015616,-0.025839116,-0.031076856,-0.014842479,-0.03894345,-0.0900902,0.05260089,-0.01384205,0.0071211825,0.045716785,-0.09212937,0.0064496268,0.005117959,-0.018882953,0.08610501,-0.058565564,-0.016395759,0.013282379,-0.041016266,-0.053972993,-0.026657533,-0.0032134838,0.018055715,0.04567829,0.03586893,-0.031135859,0.052500296,0.00079343835,-0.0012121373,-0.11986439,-0.030548424,0.07876346,-0.0345092,0.0372811,0.014202092,0.011474554,-0.04030072,0.040328182,0.097805075,-3.8337546e-08,-0.011767708,-0.1041086,0.085843205,-0.04163106,0.0069821794,-0.014151921,0.013181833,-0.0022582014,0.022362296,-0.027516656,0.08828759,0.03859534,0.020070147,-0.02267159,0.06174319,-0.0004924564,0.06805726,0.009620649,-0.05109625,-0.022676295,-0.029796638,-0.014110293,-0.04544751,-0.049647603,-0.03607322,-0.065355234,-0.0061135986,-0.008476061,-0.0076889875,-0.04575168,-0.007226886,0.029490462,-0.05378843,-0.061356224,-0.123736076,0.065340236,-0.06388873,-0.005171263,-0.050126787,0.008265788,-0.03506453,-0.09077744,-0.047385976,0.0227115,0.059189152,0.0141746765,-0.00860494,0.006049526,0.0023490295,0.02712032,-0.0019178983,-0.024463402,0.08993912,-0.03813732,-0.0877439,0.09552405,0.0017223004,-0.0729179,-0.011882956,-0.08592238,-0.03405,0.087926455,0.2213783,-0.063281335 +1.13.11.67,"A thiol-dependent enzyme isolated from rat and rabbit. Unlike EC 1.13.11.63, beta-carotene-15,15'-dioxygenase, it is not active towards beta-carotene. The secondary product has not been characterized, but may be (3E,5E)-7-hydroxy-6-methylhepta-3,5-dien-2-one.",384,0.99999994,-0.06894818,-0.017153053,-0.06560751,0.004105079,0.058795113,0.04546569,-0.05684443,0.04716318,0.02201105,-0.01068364,0.021996887,-0.05788709,-0.055449564,0.05332152,0.012783379,-0.001966946,-0.031663135,-0.03766115,0.03384293,-0.044755347,-0.032265715,0.010327066,-0.005048299,0.025627175,0.06328165,-0.010009005,0.082438886,-0.044061013,-0.11661662,-0.040729325,-0.055639718,-0.086167924,0.027060496,0.0015344393,-0.00863276,0.04037275,-0.10646943,-0.039686106,-0.012361052,-0.0020423431,0.0032196878,-0.059272423,-0.09083298,-0.044630334,0.002094614,-0.096133664,-0.032876845,0.07841867,0.011762155,0.04208008,-0.03522712,-0.09099664,0.0042816545,0.045290716,-0.00471149,-0.018514877,-0.052481133,0.018016346,0.01086188,0.060888194,0.056314874,0.037670344,-0.008022749,0.0027708174,-0.0048891343,-0.01447952,-0.02357913,-0.014013986,-0.057636894,-0.104621746,0.0039893705,-0.08189533,0.024768077,-0.036445886,-0.017964594,-0.033278864,-0.018249236,-0.00065883575,0.059729867,-0.060365006,0.037717845,-0.009697655,0.004378115,0.093480185,0.022428729,-0.005447712,-0.053541377,0.08202345,-0.048352405,0.026280833,0.013970365,0.023964249,-0.042997334,0.013578145,0.017531926,-0.048381377,0.07290886,-0.031959556,0.011500649,-0.011333412,0.026819423,0.07334627,-0.02045033,-0.07947562,-0.02357405,0.05091888,0.015216661,-0.027156584,0.031402826,-0.07468633,0.03483839,0.045370415,0.06738684,0.016894966,-0.01641279,0.093713686,-0.008652362,-0.12002628,-0.022834498,0.014771952,0.009350282,-0.026227364,0.11597607,0.08468123,-0.01220223,0.027867947,-0.035710648,-9.703484e-34,0.062628604,0.010681703,0.0018648474,0.0088638365,0.05500039,0.020956077,-0.039095912,0.034849938,-0.059337035,-0.034684014,-0.055449955,-0.030145267,0.016968053,0.0072613223,0.04670406,0.010040129,0.006292506,0.0055713397,0.118216276,-0.047800712,-0.0712503,0.025811503,-0.0856186,0.05247313,0.0027675196,0.0524115,-0.040245213,0.0741064,0.051879227,0.042125773,0.023159562,-0.07738439,-0.023913926,-0.030790424,0.032999795,-0.0015639885,-0.08936951,0.0056889337,-0.080935046,0.042316686,0.063785255,0.033657502,0.059129953,-0.08435534,0.0022793678,-0.057382185,-0.042528182,0.039291818,0.022075223,0.02351452,0.0149926655,-0.004445642,0.07518292,-0.09613689,-0.016377479,0.0684559,-0.014109875,0.045086198,0.03252862,0.06906756,-0.011316623,0.052987404,-0.069452226,0.026847906,-0.030192222,0.072183765,-0.12778476,-0.065912925,-0.10467099,0.08043806,-0.009086984,0.047852892,0.07274272,-0.086061046,0.02624134,0.014514136,-0.020748299,0.05088365,0.011248419,-0.05778662,0.0025705502,0.020494515,-0.006809185,-0.063166976,-0.0093134465,0.030457973,0.022829065,-0.025671659,0.011280094,0.08123405,0.034470674,-0.04889913,-0.10440324,-0.03414113,0.08780468,2.2334877e-34,0.011013704,-0.03415468,0.039931677,-0.084990844,0.024094468,0.10155906,-0.030890396,-0.068929255,0.03346941,0.0074317222,0.0565466,0.055239744,0.0659676,-0.055059947,0.063534446,0.082266144,-0.0258306,0.02013253,-0.04886096,-0.020051543,0.021150297,-0.0036363024,-0.036884446,0.01175019,0.003131918,0.034344196,-0.0598769,0.07590985,0.14641716,0.0063905735,0.0016945497,0.0036698119,-0.022928476,-0.032999307,-0.004862408,0.022653315,-0.107492626,-0.03967746,0.02325101,0.09337443,-0.0713656,0.012275155,-0.0059269923,0.04254363,0.029278887,0.14080045,0.0031660695,-0.060527343,-0.019474206,-0.04803335,0.039335866,-0.03276066,-0.027129782,0.04749324,0.014064959,0.045407232,0.030894829,0.07873387,0.007013806,-0.12924662,0.040546253,-0.08060184,0.021070197,-0.052062824,-0.01869635,-0.051507797,-0.07410214,0.08817672,0.04889099,0.024328813,0.06988,-0.012179332,0.023727793,0.009280089,-0.029938912,0.0058161467,-0.05144736,0.0004253496,0.02011076,-0.045962658,0.020596035,0.05402378,0.0051248954,-0.063109554,-0.03501,-0.012533756,0.013486755,0.111393735,0.036267594,0.064226456,-0.02614525,0.0598205,-0.095083386,0.07120924,0.09028849,-4.2888225e-08,0.014344009,-0.08107513,0.012711428,-0.014111838,-0.0010261101,-0.020692162,0.085631944,0.025332985,0.03892164,0.024595246,-0.05446064,0.053789787,0.05721712,-0.0059169703,0.0019189244,-0.012719802,0.054651886,-0.015611276,0.014820294,0.009116587,-0.04092076,0.05348324,-0.02360471,0.0037550982,-0.051781733,-0.06487419,-0.0039153257,-0.033884637,-0.060627542,-0.0039062495,0.017402627,0.09245573,-0.048921663,-0.07889244,-0.087958775,0.052962907,0.01356432,0.037173394,-0.04854183,0.050066818,0.005638536,-0.08236425,-0.11744443,0.023505744,-0.049251106,-0.010369553,0.0849999,0.00464963,-0.023042662,-0.04256418,-0.053575423,-0.0216926,-0.028382504,-0.033577673,-0.040268097,0.023573857,-0.006746019,-0.03708365,-0.032856796,-0.10375894,0.058946107,0.06344955,0.16485688,0.012099963 +1.13.11.68,"Requires Fe2+. The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza.",384,1.0,0.024369355,-0.027185025,-0.11630976,0.11172704,0.06838498,0.07874651,-0.0437854,0.015306341,-0.0012468924,-0.04213275,-0.0037134786,-0.01103418,-0.08654855,-0.046147775,-0.051072467,-0.011070274,-0.072361045,-0.013766259,0.01585724,-0.038157497,0.088633716,0.040722743,0.012211491,-0.032575957,-0.01946677,-0.015822463,-0.023732543,-0.0010416551,-0.049593624,-0.086756945,0.012968653,-0.016648768,0.1096969,-0.041125134,-0.007563718,0.12324696,-0.023255292,-0.095875196,0.029931609,0.021587832,0.011768928,-0.116088375,-0.022035906,0.015680049,-0.075144656,-0.03026131,0.08399836,0.018788615,-0.05164502,0.011473488,-0.09102232,-0.0509459,-0.009391885,4.0485505e-05,0.03739467,0.053719647,0.045474064,0.021975763,-0.035023656,-0.010278728,0.035151325,-0.016338648,-0.037933785,-0.011906734,-0.031988017,-0.015381159,-0.0152965635,-0.004546599,0.040808503,0.009100201,0.028794289,0.04105891,-0.11729934,0.028128043,-0.03395388,0.053872075,-0.049537733,-0.027141457,0.07589543,0.028481916,-0.014424764,0.024927951,0.021218961,0.025626,0.04370484,0.058539905,-0.020850243,0.00791194,-0.035731032,0.0932499,0.032964744,-0.042528495,-0.04458745,0.07400128,-0.026766084,0.035402518,0.08157184,-0.10779927,-0.04280378,-0.039681397,-0.05695118,0.042778477,-0.020893699,0.0029927564,0.0069838054,0.021293432,-0.10082076,0.009254708,-0.017022537,0.035731003,-0.009509259,0.0074496656,-0.006623015,0.002239282,0.037096735,0.11620285,0.05562672,-0.043585904,-0.04257559,-0.030334773,0.038059853,0.051818453,-0.0626501,0.07482212,-0.0662132,-0.016062591,-0.08623068,2.2580144e-33,0.03714312,0.04084909,-0.023235051,0.0336558,-0.022472844,0.0015117356,-0.09321828,-0.010669897,0.015107703,-0.0071059978,-0.07069137,-0.080721565,0.05045521,0.021582337,-0.008438873,-0.042246047,0.0043933494,-0.002377614,0.13402562,0.032088917,0.015743388,0.035256132,-0.057602778,-0.01916322,-0.024814429,0.07169324,0.028506028,0.009083797,0.06948776,0.0023078187,0.102897644,-0.104373336,-0.047291953,-0.036641978,0.103801854,-0.068010315,-0.058590487,-0.06600168,-0.027067112,0.035633028,0.0003774959,0.068434425,-0.0073574972,-0.049882367,0.08731519,-0.04934088,-0.022924209,0.05568715,0.036410604,0.11687826,0.041532967,0.07155869,0.14888056,0.054750755,-0.007940224,-0.024042387,-0.022347616,0.013827388,-0.030112538,0.030997325,0.021495942,0.009879012,0.049483858,0.07211582,5.5735334e-05,0.035701033,-0.055198666,0.059278846,0.016655352,0.13342102,-0.057181448,-0.025941813,-0.035811953,-0.02375255,0.017081428,-0.043674763,-0.09737197,-0.007476384,0.008173981,0.029213626,-0.04449635,-0.047813423,-0.041964848,-0.004767662,-0.06551453,0.03693995,-0.046247896,-0.009676635,0.03843864,-0.011594905,0.021276096,-0.004436785,-0.049031842,0.050254118,0.07654175,-4.3272133e-33,0.049001433,-0.08565573,0.061376825,-0.026802512,-0.06126133,0.06217501,-0.00254831,-0.14083324,0.007197663,0.06774775,-0.014997694,0.030073307,-0.017790968,-0.08276127,0.022371588,-0.01868336,-0.04961232,0.06785337,0.026968239,0.016648544,-0.064639516,0.14552625,-0.0045442586,-0.02118063,0.07083622,-0.035029773,-0.022407865,-0.00053061766,0.0020218526,0.04103512,0.08707526,-0.05846435,-0.06470184,-0.10240359,-0.044851243,0.015370638,-0.06413668,0.023268247,0.07949173,0.017548626,0.031911507,0.040092975,0.024423715,0.06759937,0.024195587,0.04430999,-0.07822623,0.05074109,0.01841599,0.01701473,-0.044959508,-0.0009930591,-0.055951465,-0.024108673,0.0625973,-0.08988306,0.010050025,-0.010238947,-0.055938803,-0.015864644,-0.039041206,-0.020256592,0.012769124,-0.008728631,0.022495244,-0.018572561,-0.015128321,0.06922057,0.057037175,0.027921362,0.07668258,0.065688334,0.03589737,0.08315559,-0.006497491,-0.02287542,-0.04766601,0.039895862,-0.043838043,-0.004650449,-0.0022003597,-0.0039745653,0.03447242,-0.07475599,-0.023476403,-0.114263676,0.041469984,0.057890847,-0.0052194376,0.052530274,-0.032671347,0.027579345,-0.03828052,-0.006106023,0.0020677093,-2.8876235e-08,-0.042220894,-0.031417087,0.002924567,-0.07365949,0.014068069,-0.039343137,-0.010636674,0.04186603,-0.009337185,0.006426368,0.0003538313,0.07457531,0.08759417,0.03191264,0.039893065,-0.048018653,0.04274286,-0.0039600884,-0.02203894,0.009824234,-0.096569546,-0.036668256,-0.122252345,0.05568877,0.018866945,-0.08760857,0.028618088,0.005664563,0.077653565,-0.0050908676,0.09709127,0.0111712655,0.035974413,-0.019694185,-0.11678003,0.07140781,-0.028366385,-0.024273869,0.014164919,-0.025195379,-0.040299106,-0.021854993,0.03076682,-0.025648512,-0.07334109,0.04603066,-0.030899905,-0.0006208899,-0.031919755,0.01955413,-0.029260175,-0.015320753,0.007332428,-0.0040472834,-0.03552506,0.07690553,0.004365471,-0.016171765,0.042266563,-0.06152369,-0.0064087966,-0.0005806248,0.107589826,-0.094478495 +1.13.11.69,"Requires Fe2+. The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza. Also catalyses EC 1.13.11.70, all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase, but 10-fold slower.",384,1.0,-0.020034304,-0.001973361,-0.11533745,0.07143005,0.07452726,0.075117275,-0.04747713,0.017764462,-0.00047181195,-0.03915753,0.01339997,-0.022578597,-0.10306033,-0.036877826,-0.06057037,0.010766593,-0.0663897,-0.0053146477,0.021903312,-0.030691653,0.06601411,0.037094448,0.011404182,-0.0077364496,0.014274813,-0.0038640494,-0.016731406,-0.011465386,-0.06869286,-0.10566464,0.009518985,-0.041839972,0.11555667,-0.023999372,-0.0074401908,0.1166447,-0.028798608,-0.119751945,0.046278276,0.04255691,-0.016789407,-0.08982709,-0.017657941,-0.020830719,-0.06970998,-0.06341675,0.055655524,0.027532194,-0.042735416,-0.0035310937,-0.05695064,-0.04505214,-0.021748994,0.0053469287,0.06801633,0.044343896,0.010921624,0.03252055,-0.026329227,0.008472315,0.035313148,-0.017871138,-0.038802154,0.027619343,-0.056032125,-0.029149637,-0.015547962,-0.033177312,-0.001882332,-0.016252466,0.016710864,0.0121355895,-0.12741512,-0.00095762115,-0.0353839,0.06397999,-0.0469572,-0.033244316,0.05706269,0.025204098,-0.019651016,0.02246435,0.00874218,0.00063253596,0.038807865,0.02403937,0.00882734,0.012442836,-0.044186678,0.10426329,0.0511532,-0.033514794,-0.020552935,0.077404775,-0.029968385,0.053757895,0.11474113,-0.07730423,-0.028895378,-0.050521716,-0.03957596,0.08486118,-0.02909621,-0.012233219,0.010451283,0.04174662,-0.063896984,0.03740017,0.007498514,0.0034036145,0.0057776207,-0.003640176,0.020176021,0.0012828194,0.01826732,0.12640868,0.040610462,-0.0631819,-0.035406046,0.012911047,0.025538512,0.012818399,-0.051007256,0.09222094,-0.09041654,0.005384632,-0.07949825,2.198606e-33,0.06495215,0.034218732,-0.043198798,0.03165396,-0.014286408,-0.0058825123,-0.118710555,0.018236922,-0.003938724,-0.029594027,-0.08400375,-0.047970094,0.051870193,0.02344967,-0.017468853,-0.05363925,0.0076809614,0.011439879,0.12861668,0.031760234,0.0064988984,0.007035251,-0.074717484,-0.007218298,-0.019047393,0.096816376,0.018410722,0.028746765,0.05381644,0.0046248054,0.082121775,-0.093896635,-0.060795683,-0.020123687,0.07546021,-0.07553972,-0.046862736,-0.07630449,-0.016645065,0.035379447,-0.0014895638,0.052356377,-0.02389251,-0.048989132,0.105812185,-0.055657808,-0.0070285164,0.07627027,0.026200766,0.12049661,0.024003606,0.07601639,0.136532,0.04373886,-0.012098721,0.0046532266,-0.009546132,0.0064592483,0.015363838,0.06219413,0.030573362,0.03893629,0.015944745,0.074897714,-0.0104404995,0.045550417,-0.04539653,0.0389298,-0.001134831,0.13493854,-0.05526627,-0.010085092,-0.010771262,-0.036416184,0.04292793,-0.022816684,-0.06769586,-0.009947247,0.0070861233,0.035067424,-0.040198952,0.008276664,-0.042207047,-0.046500843,-0.027422603,0.040576402,-0.078592725,-0.028471053,0.039759405,0.009265033,0.0058214446,-0.022821726,-0.057460867,0.02948667,0.065694176,-3.4227365e-33,0.07196591,-0.121628605,0.050013848,-0.06395436,-0.056119103,0.07376314,0.025878668,-0.12807147,0.029369583,0.046811294,-0.0243104,0.024730965,0.020858413,-0.1197963,0.028632207,-0.009480664,-0.036628455,0.07814575,-0.001547419,0.011310913,-0.028671836,0.15057583,-0.028261798,-0.008736592,0.07076471,-0.03720251,-0.04717457,-0.0018784027,0.037653245,0.019698918,0.06307081,-0.0663879,-0.05052407,-0.06434238,-0.056716543,0.05670733,-0.09810441,0.017302401,0.074861296,0.02682188,0.021799313,0.011852846,0.014008357,0.04374333,0.022519032,0.066714175,-0.10699636,0.028393771,0.028447498,0.018258123,-0.030148253,0.010163865,-0.023037525,0.005149213,0.07945804,-0.082012124,0.0005192914,-0.02302554,-0.032601174,-0.0104331495,-0.01684609,-0.023788275,0.029434342,0.008060002,0.008338724,-0.0029334307,-0.020230347,0.049679875,0.030094737,0.02482852,0.09840465,0.004615256,0.011110286,0.07149954,-0.017932238,-0.022150505,-0.022761522,0.02417357,-0.038235433,-0.0014701486,0.016084334,0.011823935,0.020720169,-0.094930224,-0.037369784,-0.10411833,0.02765487,0.03750051,-0.0025661022,0.081619665,-0.01497968,0.031659126,-0.02355266,-0.0019977342,0.02267683,-3.7193512e-08,-0.022521716,-0.03617021,0.049159843,-0.07559235,0.03671162,-0.019023927,0.012997735,0.054853406,-0.005419078,-0.022245118,0.028025415,0.065004475,0.09120972,0.023136053,0.048772193,-0.043588597,0.044166956,-0.017304009,-0.0065038186,0.026086861,-0.09739451,-0.013958797,-0.09456475,0.039642736,0.008168319,-0.093533844,0.027416758,0.017262865,0.05718883,-0.009097573,0.07621971,0.026100384,0.021357205,-0.045629587,-0.11726193,0.07157732,-0.013099994,-0.015283081,-0.004582336,-0.0020704383,-0.03665504,-0.05364648,0.00012719564,-0.02655699,-0.09338889,0.05752733,-0.027795129,-0.009307654,-0.039734434,0.05049269,0.003755555,-0.022714237,-0.002139255,-0.021388033,-0.055833187,0.07469654,0.030162562,-0.03369084,0.031929225,-0.06311288,0.020734841,0.009939357,0.15068062,-0.08655863 +1.13.11.70,"Requires Fe2+. The enzyme from the plant Arabidopsis thaliana also catalyses EC 1.13.11.69, carlactone synthase, 10-fold faster.",384,1.0,-0.0837201,-0.046984766,-0.08047422,0.047207214,0.11136377,0.030941607,-0.08543617,0.025368668,0.035300937,-0.023916084,0.03842911,-0.08293368,-0.07731011,-0.034748405,-0.02584712,-0.013924382,-0.06125451,0.04918604,-0.031498276,-0.03196608,0.029547026,-0.037747417,0.045678914,0.014251369,0.024573589,0.019461721,-0.017290518,-0.038838577,-0.0092403935,-0.08567661,-0.019762922,0.005708191,0.08711319,-0.034946643,-0.017961435,0.0672733,-0.00020537282,-0.11258941,0.041720126,0.015018443,-0.018266132,-0.07127985,0.0015475235,-0.03598549,-0.038849927,-0.0898381,0.058396235,0.0040606097,0.035320044,-0.04446668,-0.07374345,-0.020828033,-0.06856151,-0.043209285,0.026830843,0.01959185,-0.010207785,0.02136189,0.035142228,0.014269554,0.0063880878,-0.022827087,-0.013360328,-0.0068515916,-0.0028801975,-0.038415518,0.012773434,-0.03380499,0.022847578,0.027340319,-0.018763471,0.011016873,-0.04726055,-0.021697372,-0.0055542565,0.085486844,0.049574673,-0.02584634,0.039449558,-0.026137523,-0.01843374,-0.01850294,-0.015714172,0.039623044,0.039944667,0.037194803,-0.008466724,0.011299689,0.024433067,0.07610186,0.063402556,0.039272178,0.009432949,0.019687556,-0.0019303532,0.092128195,0.052833244,0.0097453315,-0.012059178,-0.017178597,-0.010239474,0.1181566,-0.08365807,-0.015465571,0.02345898,0.010638644,-0.003707236,0.10233313,-0.02437443,-0.02368417,0.09491493,-0.039723318,0.008045953,0.013054678,-0.016333502,0.07947672,0.020256152,-0.07007777,-0.044766407,0.035157192,0.033431813,0.0003868886,-0.055933386,0.06231974,-0.09266806,0.007917494,-0.14126348,2.4043763e-33,0.06255549,0.121103935,-0.019479875,-0.039582256,-0.051061183,0.029519426,-0.12564968,0.026026621,-0.08813559,-0.02439081,-0.10835776,-0.06773909,0.01877845,-0.032711215,-0.020882947,-0.09352965,-0.014313007,-0.043176718,0.04797565,-0.013103703,0.035571042,-0.03596795,-0.034302883,-0.022975493,0.0007897933,0.047340505,0.016894324,-0.033965573,0.026822273,-0.03196106,-0.02692895,-0.07860172,-0.06662959,0.043819807,0.05334536,-0.054584492,0.0107680885,-0.05297434,-0.003169191,0.011649719,-0.018528033,0.11371482,0.0021830075,-0.04803582,0.09833244,-0.01020383,-0.0044020982,0.14570019,0.07641025,0.09995981,0.017251914,0.050320942,0.07619638,-0.009970159,-0.025344588,0.028366504,0.029394476,0.015281262,0.05111352,0.095908366,0.0068476447,0.04654342,0.059786677,0.056950975,-0.013820715,0.05493497,-0.065614045,0.0013472587,0.027985273,0.088074036,-0.056034748,-0.009433936,0.08100632,-0.0076429057,0.104629934,-0.07013994,-0.07092232,-0.05504796,0.021905608,0.049911544,-0.016041506,0.021422656,-0.04717058,-0.0031697226,-0.020526964,0.0038026317,-0.07545627,0.0179852,-0.01190426,0.09527711,0.04022208,-0.06783604,0.005549825,-0.026297862,0.005174378,-1.8476887e-33,0.058135852,-0.06404731,0.012253766,-0.074453644,-0.10165566,0.019445302,-0.009034774,-0.11346111,0.017706586,0.008186824,0.06647997,0.010314963,0.08988889,-0.10407083,-0.023477335,0.032958403,-0.011428366,0.049208898,0.045067143,0.0074704583,-0.02425506,0.08238508,-0.035337,0.06920078,0.0691248,0.015543664,0.0024672996,0.082304835,0.034325127,-0.009491428,-0.027401585,-0.014280628,-0.06615856,-0.0314341,-0.061482787,0.045977753,-0.0134027675,-0.00391902,0.051938776,0.021022322,0.019151524,0.002398289,0.001134428,0.10516954,-0.028239343,0.06738295,-0.010543064,0.032148298,-0.009018045,0.027811283,0.019158611,-0.02026541,-0.08894745,0.039009165,0.025688997,-0.039298773,0.026236497,0.04433736,-0.026480783,-0.0028471933,0.027500581,-0.040531933,0.042172767,-0.02353898,0.046400174,0.04663609,-0.029740233,0.08741835,0.02576558,0.06076413,0.10369368,0.034457464,0.025545407,0.026515797,0.019443467,-0.0066225952,-0.0019213103,-0.022301126,-0.04493053,-0.059998523,0.025745075,0.046217594,-0.022697767,-0.098615445,-0.024610493,-0.03396767,0.057743464,0.07545211,-0.009622671,0.07427808,0.010965138,-0.041495204,0.022330847,0.05250314,0.033808064,-2.8337949e-08,-0.03149752,-0.07062804,0.03714139,-0.1034996,0.04820304,0.043625757,0.04459248,0.024093788,0.00024156879,-0.049470197,0.0029912333,0.040214952,0.086567655,0.020936359,0.062282473,-0.045220766,0.033345886,0.051738456,-0.037370384,-0.01127289,-0.06454142,0.023353603,-0.1689824,-0.0067692217,0.009895896,-0.078419015,-0.0032041082,0.011789042,0.031487033,-0.049688086,0.011294257,-0.007353179,-0.015700618,-0.05076753,-0.062076576,0.02565193,0.014679438,-0.03906076,-0.02162442,-0.042665515,-0.05195468,0.0025986743,-0.06485265,-0.016574485,-0.06465822,0.008855802,-0.021204505,-0.013429912,0.035620052,0.070763886,0.08834016,-0.061193164,0.056038193,-0.11836025,-0.07171846,0.04381108,0.011499394,-0.045447864,0.01857344,-0.033058137,-0.0060981857,-0.061211668,0.16370988,-0.090318516 +1.13.11.71,Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene.,384,0.99999994,-0.012475132,-0.054561447,-0.07967294,0.063730806,0.08422175,0.0016345384,-0.08799611,0.019971007,-0.024987273,-0.0223091,-0.015666101,-0.0057862946,-0.07333931,0.038554557,0.030033821,0.037723575,-0.1194028,-0.011715139,0.008926703,-0.004062893,0.087015845,-0.027777044,-0.017817564,-0.015242028,0.027583223,-0.054668132,0.03869613,-0.12850828,-0.04099891,-0.0121422075,-0.056063894,-0.074190706,0.0029705332,-0.0548862,-0.02929394,0.028292133,-0.03963955,-0.042423714,-0.006637788,0.017521005,-0.0020737213,-0.089541994,-0.05051826,-0.0149959875,0.0016931733,-0.05675607,0.01463862,0.017093068,0.0058630393,0.080450036,-0.08804266,-0.017647164,-0.067528084,-0.03562076,-0.00929555,0.039847735,-0.066262364,0.016438615,0.050894786,0.028301883,0.027812328,0.010605124,-0.008261876,0.015334765,0.07316631,-0.066006966,0.003651592,-0.038386654,-0.00070461165,-0.013249576,0.01952855,-0.07994773,-0.0021723644,-0.0024540315,0.0394479,-0.015840456,0.009734245,-0.022808691,0.017804505,0.034918174,0.031836387,0.0109019475,0.028914977,0.08553787,0.07932962,0.044602904,-0.07194803,0.026637256,-0.06085733,0.050668743,0.011716044,-0.007321588,-0.047061473,0.073142104,0.04071188,0.022601858,0.08743549,-0.05800216,-0.018048644,-0.05084581,-0.052701954,0.06927845,7.840283e-05,0.0031272706,0.006646434,0.010603023,-0.011278843,0.043899328,-0.024577772,-0.033498757,0.102462195,0.066866405,0.04140046,-0.03166681,-0.0057899207,0.09044538,-0.04219183,-0.083841786,-0.075347334,0.025683163,0.0024628956,0.10380204,-0.018442405,0.10624922,-0.032296468,0.04757173,-0.030785529,2.9849293e-33,-0.0004291331,0.09743483,0.00254435,0.036485348,-0.056782562,0.009736451,-0.0831286,-0.006883465,0.012714578,-0.026457785,-0.09000375,-0.045251764,0.06509321,0.01867652,-0.02042371,-0.03789395,0.011123251,-0.054042086,0.05533562,-0.00028053822,-0.006321181,-0.031059982,-0.016777538,0.033473954,-0.03897448,0.046256296,-0.012406248,0.050976813,0.0018479129,0.017915782,-0.0051462664,-0.09878501,-0.049349047,-0.0067207897,0.08575005,-0.042884044,-0.057355452,-0.065353155,-0.061955437,0.056989226,0.011575494,0.04776007,-0.040658668,-0.029818626,-0.009338271,-0.06432305,-0.02049556,0.09442024,-0.0058656107,0.07026973,0.030767968,-0.0009364166,-0.012065051,-0.026512712,-0.04479211,0.0026609218,-0.0054360074,-0.05191637,0.0028043196,0.022762032,0.016931474,0.02739806,0.041126028,0.028353287,-0.014358547,0.021053255,-0.090301685,0.00027654853,-0.035760622,0.026259296,-0.04837277,-0.0041210824,0.051614657,-0.026996074,0.05172023,-0.0169895,0.029928524,0.021014808,0.069150954,0.003873599,0.020231683,0.0031639864,0.051378027,-0.049067687,0.036058847,0.018276274,-0.018137118,-0.078617275,0.05595652,0.0641213,-0.029904252,-0.040070236,-0.023688318,-0.06485974,0.030921219,-3.5494074e-33,0.03673811,-0.11905347,0.044392016,-0.018905835,-0.006159607,0.011413957,-0.06276158,-0.1820118,0.033022065,0.0061507616,0.022305598,0.028864188,0.055565353,-0.10972498,0.063622035,0.05738373,-0.011184862,0.0818341,0.0074308477,-0.009651782,-0.018626051,0.07995683,-0.032952964,0.03742571,0.06378323,0.031827156,-0.103067964,-0.03520687,0.13943604,0.044037394,0.029331291,-0.056417245,-0.054590225,-0.023237724,0.041681316,0.086788096,-0.051431756,0.025248308,0.072355255,0.061826274,-0.056800775,-0.017827999,-0.016611367,0.040823795,0.03405963,0.008750635,-0.06899471,-0.02423128,-0.0445209,-0.01719899,0.095162205,-0.010626096,-0.047208842,-0.04333946,0.015120672,0.008311723,0.1095418,0.034943078,0.046796553,-0.016405659,-0.00617041,-0.06290531,0.014392353,-0.05525809,0.031025257,0.0060183,0.018722206,0.14161378,0.02231139,0.007420119,0.1334446,0.06434338,0.0573179,0.0069108196,-0.01975627,0.01966626,-0.041253667,-0.002196383,0.0004006286,-0.03430116,0.026086751,0.04594886,0.037395753,-0.04365923,-0.036511194,-0.039987095,0.012604124,0.052172754,-0.026618483,0.016287373,-0.027981123,-0.10166147,-0.04194472,0.045455594,0.13920671,-3.211417e-08,-0.029550858,0.033517305,5.3124502e-05,-0.044015404,-0.004861154,0.0028580637,-0.025514571,-0.0017031388,0.05489054,-0.030631052,-0.030801509,0.06353756,0.08007724,0.0056684795,0.024589045,-0.04054176,0.028508686,0.059045423,-0.026622951,0.08542848,-0.086065225,-0.0061719483,-0.16035762,-0.0019146047,0.040139776,-0.085348375,0.0099402,0.046584424,0.048575785,-0.032761876,0.050705858,-0.0172375,-0.016532557,-0.0018134027,-0.10679748,0.02371755,0.05327606,-0.021505464,-0.05545,0.034677573,-0.031197937,-0.0048790053,-0.029937962,0.030848555,-0.11850743,-0.015497653,-0.0047196527,0.0063816574,-0.051698107,0.06870958,-0.0034412618,-0.054857362,0.013274376,-0.04148731,-0.0726067,0.03341565,0.042455062,-0.0013636838,0.029164443,-0.10360614,-0.010053266,0.1027859,0.18940286,-0.06045957 +1.13.11.72,Requires non-heme-iron(II). Isolated from some bacteria including Streptomyces hygroscopicus and Streptomyces viridochromogenes. The pro-R hydrogen at C-2 of the ethyl group is retained by the formate ion. Any stereochemistry at C-1 of the ethyl group is lost. One atom from dioxygen is present in each product. Involved in phosphinothricin biosynthesis.,384,1.0,-0.036541127,0.011476834,-0.13962583,0.025796697,0.108192645,0.06520112,0.012729099,0.108429946,0.06553014,-0.020911707,0.027645411,-0.060788605,0.037014116,0.012593489,-0.034022875,-0.06220815,-0.06679635,-0.012637377,-0.004014429,-0.010691533,0.04891506,0.055446774,0.02119191,-0.020425152,0.003932455,0.006096067,0.059524775,0.085880905,-0.033612028,-0.048203733,0.059349407,-0.059909705,0.056016393,-0.08150532,0.096898824,0.034211125,-0.028150419,-0.044006824,0.10812606,0.00392352,-0.021897445,0.019334698,-0.041096482,-0.0013522701,-0.05733515,0.03255417,0.047727562,0.040300824,-0.007560256,-0.012903201,0.031755704,0.0066042566,-0.052691218,0.09812109,0.0077820136,0.037329674,-0.021613328,-0.056965113,-0.015325183,-0.043268573,0.051672924,-0.0630288,0.030488659,0.021968197,-0.11983992,-0.02188521,0.056817498,-0.061924286,0.04125037,-0.039526954,-0.07815613,0.02375288,-0.030254753,0.05073506,0.03774986,0.060451735,0.07637793,-0.06543033,-0.045644894,-0.028838366,0.014761132,0.024019606,0.0030435359,0.0902899,0.012221087,0.0019495077,0.021637091,-0.015124782,-0.013142415,0.013590402,0.0027807963,-0.006678806,0.043958303,-0.102052905,-0.013025196,0.029933887,0.013239362,0.033929657,0.07382565,0.015466746,-0.07704216,-0.013519656,0.0056938413,-0.06835267,-0.051721025,-0.029093001,-0.04054485,0.044465836,0.03762539,-0.0069384472,0.061814055,-0.0444003,0.00434712,-0.056062415,0.011859719,0.06031865,0.12702008,-0.07271583,-0.075209886,-0.042740524,0.030351862,0.009956527,0.058219858,-0.02193714,-0.0482639,0.0076658083,-0.07219659,5.703139e-33,-0.010123665,0.064482585,0.010228482,-0.03710361,0.027190428,0.0015999213,-0.09999162,-0.032814387,0.010770037,-0.02788702,-0.09567301,-0.08378429,0.028658759,-0.051334657,-0.047700305,0.032340404,0.02041233,0.053823233,0.009204784,-0.0014009672,-0.004615127,0.07987272,0.051513936,0.008482944,0.03486155,0.08136902,0.03992234,-0.0463077,0.09459746,-0.03593477,0.065100245,-0.03588834,-0.04415382,-0.0029131372,0.09824254,-0.002239615,-0.09319173,-0.0137806665,0.05478102,-0.009035083,0.017221086,0.07126178,-0.019072797,-0.026632408,0.10488186,-0.102563284,-0.058019973,0.05305112,0.022249078,0.09499424,-0.03612225,0.061984535,0.1097361,-0.031565297,-0.07950995,-0.048225652,-0.009502228,0.040886413,0.103483096,0.024512734,0.007123548,0.10811357,-0.03627195,0.014719973,0.052126657,0.027864696,-0.09261388,-0.013439029,-0.059484083,0.026095495,-0.030736154,-0.030040562,0.017589314,-0.010924026,0.027380764,-0.016598476,-0.07976709,-0.04714592,0.074295364,-0.0032318356,-0.055027753,0.043193255,0.0010915198,-0.026176617,-0.046971746,-0.02419409,-0.0757692,-0.006969308,0.021673698,0.044365488,-0.004467318,-0.039786696,-0.09925298,-0.013884871,-0.0030241183,-7.1571685e-33,0.056344356,0.02177699,0.011972205,-0.06259206,-0.008720616,0.10040909,-0.027216634,0.020721776,-0.016051587,0.0042178826,0.117160834,-0.0025656247,-0.088895924,-0.05476634,0.024689598,0.0010580807,0.0027454866,0.14806816,-0.017891148,0.05259327,0.056694843,0.053502005,-0.0040883413,0.009232549,0.04893175,-0.017078873,0.02380509,0.07636738,0.008308097,0.04006366,0.04864591,-0.035684656,-0.03649934,-0.11350137,-0.06836083,-0.006266345,-0.023293547,0.02000898,0.0009819028,0.029386196,0.03779846,-0.032886766,0.072066575,0.054461733,0.016297663,0.034227878,-0.12585923,0.03686511,0.008375169,0.020228945,-0.04027811,-0.019604484,-0.06692963,-0.05883052,0.029212514,0.00205452,-0.015276753,0.09734937,-0.051322512,-0.040086344,-0.035189997,-0.05432346,0.012760414,0.029097779,0.04086437,0.016943049,-0.011460629,0.024242362,0.035909843,-0.02339428,0.03156025,0.04834175,-0.0050558476,-0.111133456,0.0023754656,0.00036406884,-0.051731046,-0.038583428,0.04874767,0.043064,0.0059870956,-0.048128948,0.034595404,-0.0041048243,0.013436679,-0.051046427,-0.01276234,-0.035473578,-0.05209568,-0.018238846,-0.03533684,0.0023653554,-0.0011250941,0.02839452,0.03482065,-4.4127038e-08,0.06299884,-0.032019835,0.07791274,-0.04665701,-0.0011425577,-0.061943002,-0.014011674,-0.056493357,0.015016531,0.022235045,0.0014388559,0.01452074,0.014072133,-0.06669358,0.0246964,0.045969374,-0.06391706,0.055743832,-0.029842192,-0.024369648,-0.06699381,-0.022489164,-0.057468712,0.0640006,0.042629495,-0.053815063,0.051721938,-0.108992286,-0.04065157,-0.010544876,0.049989067,0.005479301,-0.06426219,0.0011855166,-0.07031564,-0.09292365,-0.098108396,0.039526634,-0.042381383,-0.03526224,-0.008117156,0.03583164,-0.08954923,0.039642002,-0.029044352,0.05415805,-0.039876327,0.02294273,-0.09498335,-0.040482644,0.017466255,-0.013349315,-0.013696801,-0.04083679,-0.13928182,0.049269468,0.06716977,-0.034766637,-0.047119815,-0.038220525,0.004458622,-0.03057329,0.15773103,-0.022331253 +1.13.11.73,Isolated from the marine archaeon Nitrosopumilus maritimus.,384,1.0,-0.04799009,0.09009519,-0.062337045,-0.023533434,0.014101955,-0.021305144,-0.028212214,-0.02597552,0.06337254,-0.06791626,0.031465337,-0.06117472,-0.02550353,0.0125521,-0.044150237,0.035486985,-0.03963797,0.017066097,-0.0063462737,0.05695259,0.07323969,0.10645672,-0.03620361,-0.017572455,-0.07621193,0.014335878,-0.060426902,-0.026471686,0.00027737315,-0.08185857,-0.032591462,-0.008563532,0.049270507,-0.06363672,0.12458183,0.0050773304,-0.039859172,0.009180286,0.026921703,0.06299528,-0.00032726035,-0.0009911113,0.09190709,0.01190649,-0.10307375,0.01478691,-0.052431032,0.002713579,0.03869234,0.020187823,-0.044432685,-0.06752337,-0.031238312,0.051849768,0.04829001,-0.013457489,-0.040889192,-0.082662396,0.020198073,-0.05352275,0.1518992,0.08210739,0.019888163,-0.01382154,-0.033296574,0.025481114,-0.05547476,-0.024383813,0.11319596,-0.070926085,0.05493371,-0.008769684,0.00016488426,0.056573365,-0.06420255,0.03823343,0.046644166,-0.0004740618,0.03113045,0.02604791,-0.005220542,0.050211094,-0.024345024,0.00035410206,0.042567007,-0.040571958,0.049191643,0.11613306,-0.034704905,-0.0046216785,-0.002290794,0.017664833,0.030025966,-0.11252647,0.0011384503,-0.031962946,-0.05880273,0.019705791,-0.06997432,0.020280749,0.105515346,-0.021257618,0.0005010411,-0.09492628,-0.073369,0.018909005,0.026077695,0.0101097785,0.09684586,-0.0029860602,-0.028135717,-0.01640213,-0.0520973,0.042603884,0.015740404,0.09420589,0.04741816,-0.048106585,-0.016397024,0.028371254,-0.0387212,-0.08679811,0.09187047,0.0026897253,-0.0033676352,0.12144738,-0.07156033,1.7738654e-33,0.04024704,-0.057415858,-0.031964965,-0.029115865,0.06366224,-0.06448645,0.018902564,-0.060086623,-0.024666224,-0.025741022,-0.09431389,0.049809694,-0.061969787,0.025788529,-0.02452859,0.009786015,0.018781397,0.03363828,-0.012305583,-0.03265406,0.010804441,0.084813856,-0.035871737,-0.048918627,0.022362705,0.0026507345,-0.041637413,-0.10397422,0.012167531,0.0062477835,0.06385076,-0.14023711,-0.023377672,0.06398479,0.09301368,0.04225127,0.019513387,-0.02888068,-0.056472685,-0.04563355,-0.031183982,0.017152475,0.06194004,-0.0018854847,0.072457,-0.00045955647,-0.021990737,0.0521634,0.09337187,-0.03935465,0.0010578327,0.048521467,-0.0041304757,-0.026093949,-0.07393618,0.025337145,0.030513927,0.070989914,0.030074831,-0.053072207,-0.047777608,0.08486117,0.031646132,-0.0020858534,0.11543501,0.062949345,-0.06775088,0.016861644,-0.005665213,-0.0056602675,-0.06523265,-0.030926423,-0.019213436,-0.03504615,-0.0073970747,-0.031598493,0.031166997,-0.038046524,-0.10607619,0.03233481,0.0069230204,0.053942773,-0.0005900118,0.0073105088,-0.0930487,0.054976877,0.03348635,0.103371516,0.035034508,0.0679292,0.016508464,0.028072312,-0.10578247,-0.03604757,-0.0035345308,-1.5931714e-33,0.045014564,-0.018029736,0.018067822,-0.11187173,-0.04574239,0.070323244,-0.060510803,0.044546727,-0.034984335,-0.030804966,-0.049543258,0.042924892,0.06414054,-0.029259205,0.034837186,-0.023547182,0.058229096,0.08350896,0.029340439,-0.039815105,-0.07100693,0.034848135,-0.0055073774,-0.0021332228,-0.045549646,0.027409922,0.046672612,0.013858609,-0.0045287227,-0.08196847,0.041491475,0.088883094,-0.018157199,-0.07253166,-0.027717907,0.0008891388,-0.11668325,-0.07413104,-0.020849207,-0.017736776,0.01114535,0.053020585,0.043224644,0.020679777,0.023888977,-0.006029374,0.042839352,-0.010592196,-0.03814814,0.06954234,0.015105868,-0.047276646,0.060556445,-0.027223963,0.07398665,-0.04997573,-0.0555377,0.086615406,0.00898785,-0.011933478,-0.029497137,-0.0049217814,-0.04882974,-0.023554493,0.022782026,0.039048664,-0.026634412,0.06873124,-0.0749939,0.04094942,0.043929294,0.052945115,0.027645707,0.07804876,0.05900043,0.025167229,-0.002770084,-0.06701879,0.025379194,-0.06924935,-0.0321471,0.010585812,0.012262581,-0.1067019,0.016581636,-0.03555465,0.053969327,0.042713474,0.016327403,-0.045746334,0.034857996,0.016789068,-0.1338221,-0.053781886,-0.029263547,-1.9544308e-08,0.09340051,0.04799448,0.02666721,0.05597528,-0.079336286,-0.048889566,0.064064816,0.03275417,0.010963368,-0.002494714,0.05245662,-0.040518627,0.019514147,-0.08727332,0.015038855,-0.006608714,0.025811816,-0.00908328,0.01507125,0.014623001,-0.028342048,0.004236143,-0.008858638,0.005737944,-0.07879251,0.043312244,0.10164892,-0.05388182,0.06496011,0.021818835,0.04878388,0.018895295,-0.05291906,-0.033828553,0.011444392,0.039309118,-0.06963753,0.017193375,-0.02318104,-0.049412988,-0.013526215,0.011644866,-0.027057331,-0.026001154,-0.111028746,-0.0107752625,-0.021891162,0.0049860743,-0.03732378,0.009981409,-0.015148931,-0.036950637,0.051008925,-0.03581425,-0.07069146,-0.03281904,0.11136866,-0.018885382,-0.06026619,0.014441597,-0.009792071,-0.010190489,0.042262115,0.11754454 +1.14.11.35,The enzyme requires iron(II) and ascorbate. Isolated from the bacterium Streptomyces avermitilis. Part of the pathway for pentalenolactone biosynthesis.,384,1.0,-0.0067139,-0.021209182,-0.14248595,0.10141537,0.011219303,0.010619351,-0.05350187,-0.0005328439,0.021249274,-0.06926158,0.006994838,-0.015326107,-0.08721366,0.0022210223,-0.05075204,-0.04535445,-0.029177329,-0.0076632234,0.034694616,-0.0009310534,0.13575718,0.034951456,0.0104260575,-0.10855511,0.03539217,-0.024252756,0.014353329,-0.019667055,0.0068672225,-0.077348985,0.0090237865,-0.071051046,0.07041229,-0.12443641,0.10468668,0.06825069,-0.036712687,-0.053967975,0.06397871,0.046681054,0.003082567,-0.028217424,0.033379804,-0.0042670006,-0.05406308,-0.006863528,0.07564609,0.058617983,-0.020566992,0.02162779,-0.083860904,-0.023924945,-0.023799509,0.008521822,-0.017105052,0.011885539,0.03797964,-0.055815812,-0.029609185,-0.04606014,0.077534795,0.0026364767,-0.053205576,-0.031314675,-0.064336635,-0.014898865,0.045102376,-0.02493156,0.048889726,-0.022244051,-0.0181761,0.03059026,-0.07244249,0.03167067,0.017684266,0.052774657,-0.0102141,-0.05122912,0.024576675,-0.01915369,0.01565467,0.04053387,-0.008415764,0.10004428,0.06258307,0.042885106,-0.02657171,0.038527504,0.03503937,0.09798385,0.016705038,-0.026143765,-0.02776417,-0.03884677,-0.024131756,0.028740525,0.028208116,0.0270488,0.0037749244,-0.02708121,-0.04314679,0.0051197293,-0.02185639,-0.0019238623,0.010346648,0.038644616,-0.081118464,0.03493174,0.06740314,0.008353972,0.007443381,0.00016196506,0.010223765,-0.06592053,0.05921799,0.037696708,0.070527464,-0.069310606,-0.022350939,0.057733104,0.056281943,0.052397586,-0.023087904,0.080858484,-0.010116593,0.021180963,-0.07231746,1.7068722e-33,0.033866715,0.075261675,0.026661832,-0.022802522,-0.006494471,0.03570854,-0.09180879,-0.06774449,-0.041842513,-0.03204177,-0.086080246,-0.123732656,0.036403116,0.0032079418,-0.023165472,-0.025366979,0.036768757,0.003617666,0.10208206,0.008951933,0.08946094,0.09252158,-0.0502687,0.007820703,-0.016147237,0.047879435,0.01246258,0.039042428,0.05919907,-0.013483047,0.07415905,-0.081282996,-0.0845248,-0.057941496,0.13602644,-0.06022667,-0.00032183752,-0.04761203,-0.029708534,0.050446723,0.04587091,0.07239163,-0.04683105,0.0059973886,0.13380499,-0.04803647,-0.036336415,0.082010366,0.086419694,0.048709176,0.0021607322,0.059081763,0.13666637,0.02196658,-0.08216515,-0.011355646,-0.053357128,0.007815628,0.03970098,0.05824532,0.023515146,0.04850065,0.028342422,0.029300492,-0.003050585,0.042660516,-0.04582236,0.014912548,-0.017328734,0.042945333,-0.08979517,-0.051325206,-0.0004130539,-0.008058256,0.0028502424,-0.032516256,-0.09046002,0.0013038393,0.030657113,-0.037444487,-0.066580325,-0.018626036,-0.034640368,-0.05519351,-0.05957859,-0.010294307,-0.044449743,-0.0031867789,0.042624548,-0.0003241125,0.003059049,-0.03542264,-0.117377795,0.009426729,0.040752232,-3.0292893e-33,0.059057154,-0.08346126,0.08166884,-0.03312978,-0.11845929,0.06693436,-0.02802625,-0.048058763,-0.014317232,0.025224712,0.033143476,-0.0084712235,0.010908,-0.07012941,0.0128035275,0.030251693,-0.018769586,0.16567871,0.059406325,0.03812646,-0.042990662,0.08981156,-0.014476158,0.0014542561,0.054963544,0.0069336216,-0.032558866,0.025240043,0.013146774,0.05103847,0.04490106,-0.006289711,-0.03832585,-0.11273735,-0.10676052,0.043744273,-0.051283598,0.01071905,0.054569457,0.040935338,0.046732586,-0.013823969,0.052745484,0.1272148,0.02866473,0.029254554,-0.118801184,0.054944724,0.022739062,0.020407064,0.022259451,-0.033415854,-0.046748247,-0.0149095105,0.0341734,-0.036978077,0.03213384,0.041707836,-0.001751107,-0.018552242,-0.034651153,-0.036903773,0.043491345,-0.03559267,0.12966669,0.016137213,0.008216252,0.12130163,0.04448868,-0.0071512265,-0.017161794,0.08724705,0.029347707,-0.02763257,0.03925329,0.037980605,-0.08742251,-0.017630909,-0.02159734,0.013392632,-0.05772057,-0.047650397,0.022463035,-0.044685286,-0.022043249,-0.069664896,0.07300471,0.019051429,-0.02732965,0.044554576,-0.070302986,-0.059816007,0.007808553,0.016331648,0.021587502,-2.8721988e-08,0.00388433,0.0064346753,0.03517759,-0.05975433,-0.015481949,-0.036132567,-0.014575525,-0.048759315,0.018996196,0.020687219,-0.016274298,0.04430592,0.047709595,-0.0053210077,0.039531335,0.0051393528,-0.009934483,0.000520508,-0.019456489,0.010523371,-0.051089816,0.019172039,-0.07696426,0.035340056,0.02824598,-0.08393264,0.062160864,-0.0075057875,0.026910009,0.002696442,0.004814239,-0.015821476,-0.030922994,-0.027541205,-0.12429974,0.007832497,-0.08434072,-0.045073364,-0.011519029,-0.020911546,-0.0009112516,-0.05245956,-0.026801694,0.019136595,-0.04196386,0.025873879,-0.04508547,-0.0059995106,-0.06470138,-0.022834314,0.0027728293,-0.016801486,0.0017755043,0.025746616,-0.07169075,0.07623138,0.0079741785,-0.03560028,-0.020975308,-0.016436003,-0.022758476,-0.031033354,0.1510059,-0.078158766 +1.14.11.36,"Requires iron(II) and ascorbate. Isolated from the bacteria Streptomyces exfoliatus, Streptomyces arenae and Streptomyces avermitilis. Part of the pentalenolactone biosynthesis pathway.",384,1.0,-0.016155332,-0.006178116,-0.15025912,0.097358696,0.011658791,0.027952703,-0.016396767,-0.016254809,0.04528769,-0.050652638,0.016769195,-0.02880756,-0.059746407,0.007882109,-0.030084444,-0.048685797,-0.026924422,0.017700413,0.028665923,0.014399437,0.11261257,0.06914924,0.0106789665,-0.10311627,0.019627612,-0.0019053402,-0.009083104,-0.017412143,0.008224921,-0.088860676,0.014307707,-0.06270654,0.05784716,-0.11729175,0.11455554,0.07854668,-0.04105593,-0.054501712,0.117310695,0.052615255,-0.014709707,-0.020267274,0.047421876,-0.0024487576,-0.03681794,0.024287406,0.07720615,0.046625387,-0.0175622,-0.012313266,-0.073272444,-0.009350174,-0.049285203,0.047121126,-0.0028520706,0.024138203,0.044359572,-0.056285664,-0.015091732,-0.040636744,0.07881091,-0.04442799,-0.021639463,-0.044451546,-0.113115616,0.01192804,0.020408683,-0.022805993,0.060508013,-0.02632349,-0.017362583,0.04141026,-0.064347476,0.06739306,0.013992544,0.102927685,0.010132863,-0.042177003,-0.0043822573,-0.03192969,0.008581243,0.026210172,0.0069596,0.09509609,0.054552827,0.013105794,-0.016693028,0.046144523,0.022272822,0.1072718,-0.004498033,-0.019927815,0.009294853,-0.046037596,-0.03637629,0.0156373,0.02184823,0.016434802,-0.0006550698,-0.017943598,-0.06457553,0.00070584734,0.0010961376,0.0008395224,0.00039062506,0.006358088,-0.07369545,0.032903843,0.051315058,-0.003312994,0.006723573,-0.01449617,-0.01621041,-0.07430457,0.060234,0.012735931,0.10806489,-0.07231593,-0.019265272,0.021259202,0.038464867,0.04694923,0.0090930965,0.05141922,-0.01331239,0.00076706853,-0.06568637,5.081912e-33,0.022593945,0.048223294,0.051999595,-0.004809705,0.011364266,0.030088773,-0.08143987,-0.102579616,-0.0021081555,-0.03875462,-0.10014256,-0.08284203,0.04160445,0.00015195447,-0.00805403,-0.028217489,0.021617107,0.014010915,0.099462695,-0.013712447,0.06624818,0.121673554,-0.029714523,-0.013256109,-0.006859188,0.041543808,0.009226388,0.002703879,0.054438327,-0.024663664,0.08509358,-0.08425503,-0.08190446,-0.06607427,0.13249102,-0.035733383,-0.014208604,-0.04416486,-0.008196439,0.020248024,0.036952823,0.0806367,-0.044193864,0.014279748,0.09350059,-0.022752034,-0.034391414,0.07082336,0.06894666,0.03818483,0.0008465202,0.07140074,0.13766468,0.023266237,-0.07705791,-0.03447096,-0.04502303,0.016659157,0.036543816,0.0652444,0.047876257,0.03556227,0.004973431,0.043280825,0.022614723,0.042490132,-0.07019923,0.030613665,-0.024402842,0.0142845325,-0.07535652,-0.03731501,0.011742858,-0.044650532,-0.02303902,-0.0167888,-0.09914333,-0.018337412,-0.0013929725,-0.038185205,-0.08732286,-0.010362425,-0.036356594,-0.045687556,-0.06619221,0.028239619,-0.045232367,0.0028670775,0.058014344,-0.0009291058,-0.02997976,-0.023294792,-0.106101654,0.013263491,0.026215753,-5.7832772e-33,0.06691937,-0.06530789,0.07756952,-0.029755555,-0.09443388,0.08096516,-0.03738619,-0.03124051,-0.046185393,0.020323716,0.021444378,0.019678209,0.0033268118,-0.0716795,0.007292743,-0.008335315,-0.0057795383,0.16525936,0.043892667,0.034361858,-0.023028655,0.089098945,-0.024002116,-0.0027847516,0.036412887,0.024972897,-0.042229652,0.019410849,-0.008314769,0.05277716,0.042376563,0.00062232953,-0.032940995,-0.12778981,-0.1108311,0.015202353,-0.05721729,-0.010050079,0.042824373,0.01663907,0.05873582,-0.019221753,0.04096429,0.14683042,0.03809388,0.020404268,-0.09502355,0.080623105,-0.004832763,0.058796167,-0.012843124,-0.04684422,-0.075004734,-0.031064205,0.033710897,-0.053764753,0.039109603,0.045891173,0.009936862,-0.014417388,-0.016954822,-0.033516344,0.02088482,-0.0436163,0.14408503,0.023228435,0.015396642,0.10963044,0.04276537,-0.006746304,-0.002287423,0.06796406,-0.00029544847,-0.04889057,0.066150025,0.05137505,-0.07132384,-0.02844432,-0.021552624,0.03625106,-0.052658632,-0.068664394,0.022397878,-0.028431952,0.0069892933,-0.06129197,0.055033404,-0.021997442,-0.031124923,0.0317462,-0.07767785,-0.051362563,0.034446754,0.028326813,-0.011724871,-3.4324056e-08,0.00046961204,0.03152576,0.027926166,-0.02818058,-0.025735678,-0.050970204,-0.020050015,-0.019237904,0.026674382,-0.005955699,-0.00064277445,0.007295354,0.06752487,-0.0016407977,0.044976756,0.011611084,-0.01105764,0.00052401435,-0.017429238,-0.026857639,-0.08509018,-0.0035641757,-0.05404192,0.056116477,0.019743152,-0.084535696,0.042856444,-0.040006567,0.045888923,-0.002400944,0.03211563,-0.03518011,-0.01615106,-0.03004757,-0.09901114,-0.015122838,-0.09453231,-0.0372893,-0.0036329948,-0.017850948,-0.033452448,-0.05478152,-0.041589055,0.02797113,-0.07407958,0.05387486,-0.056113996,0.027121106,-0.0876618,-0.033245403,-0.0008344534,-0.017089132,0.029318914,0.016808933,-0.09310744,0.08960164,0.035909187,-0.008372855,-0.0074549075,0.006243331,-0.024260757,-0.039657544,0.12369083,-0.046551235 +1.14.13.166,"Contains FAD. The enzyme catalyses the oxidation of 4-nitrocatechol with the concomitant removal of the nitro group as nitrite. Forms a two-component system with a flavoprotein reductase [1]. The enzymes from the bacteria Lysinibacillus sphaericus JS905 and Rhodococcus sp. strain PN1 were shown to also catalyse EC 1.14.13.29, 4-nitrophenol 2-monooxygenase [1,2] while the enzyme from Pseudomonas sp. WBC-3 was shown to also catalyse EC 1.14.13.167, 4-nitrophenol 4-monooxygenase [3].",384,0.9999999,-0.07716355,-0.034112,-0.07689026,0.00043558108,0.09958143,0.06566443,-0.08441557,0.008479283,0.04815838,-0.07709349,-0.041038267,-0.030257626,-0.044809252,0.023995034,-0.09716924,0.017094009,-0.06873287,-0.016381536,0.008553453,-0.01245692,0.018095186,-0.016469406,-0.05251572,-0.033704102,0.01243555,0.053593323,0.06227954,-0.11646536,-0.092162095,-0.04674173,0.082262956,-0.085425295,0.11332144,-0.08222304,0.039371844,0.020525984,0.010867379,-0.041412476,0.09843404,-0.00319297,0.006863337,0.014150725,-0.0008972895,-0.049844027,0.0013391719,0.042355355,0.04467995,0.029790934,0.0696966,-0.053837653,-0.042178728,-0.029022835,-0.004796554,0.05498318,0.06898173,0.023179455,-0.06619446,-0.059769154,-0.0038137957,0.04261717,0.05865457,-0.04769542,0.03282183,-0.015133361,-0.033301625,-0.014879701,0.033601508,-0.01884398,0.009742782,-0.074344724,-0.04541307,-0.011604175,0.05059663,-0.025213689,-0.00985152,0.052188918,0.055626392,-0.0022803359,0.06256059,-0.04715854,0.008841439,0.016641822,0.044339024,0.07484414,0.04376284,-0.0689782,-0.031006824,-0.011187168,0.02964375,0.09417869,0.02916963,0.01715842,0.08022371,-0.038978565,-0.023124876,0.06309598,-0.061773594,0.0659169,-0.0030078152,-0.052359316,-0.0140288,0.032735825,0.00848828,-0.05978417,-0.055640727,0.01754154,-0.0034354394,0.13774765,0.095867775,0.013844579,0.06014848,-0.02675148,-0.0056568505,-0.047914427,-0.018762562,0.06108955,0.053785425,-0.06732043,-0.17611139,0.031004243,-0.001078727,-0.020240901,0.07662188,0.011168884,-0.039139546,0.03346763,-0.033701867,6.3215485e-33,0.055205308,0.028023224,-0.0463586,-0.03970764,0.03719918,0.00457653,-0.08685324,0.053044617,0.034111533,-0.06997673,-0.012029834,-0.036695402,0.008477074,-0.049868155,-0.0036761602,0.03646929,-0.01719637,-0.028569091,0.07692668,0.037389647,0.026419379,-0.021195086,-0.063834906,0.017223045,0.028587809,0.027064659,-0.005911345,-0.056497984,0.016111596,0.008530659,0.0015411794,-0.11350974,-0.075195946,0.0015099858,0.021489684,-0.012068431,-0.03600832,-0.01732892,-0.0355252,0.066788495,-0.05489279,0.041619897,-0.046718996,-0.052553553,0.08346463,0.008318106,-0.060070194,0.141648,0.033889234,0.1394609,0.0009860465,-0.047343694,0.124593236,0.027455727,-0.020419111,0.04722134,-0.013393315,0.011921005,0.0915888,-0.016470617,0.04393035,0.11684506,-0.020842133,0.0025145875,0.020397734,0.008243978,-0.008742225,-0.024897961,0.01004035,0.060813062,-0.047374155,0.038629767,0.060342297,0.03812423,0.014554548,-0.07432816,-0.050165795,-0.035838924,0.033484023,0.0586687,-0.00022474355,0.007953957,0.03113914,-0.026994426,-0.01072407,0.03137807,-0.011325611,-0.008928615,0.0041787094,-0.002399499,0.03691148,-0.11856567,-0.07993296,-0.0037053463,-0.028720768,-4.6207103e-33,0.11670515,-0.11053871,-0.0076866047,-0.07200486,-0.034266308,0.027261242,0.00583443,0.009176893,-0.022506628,-0.014580712,0.06291816,-0.043457612,0.03962081,0.0700341,0.04596792,-0.017214613,-0.037670698,0.047096763,-0.011625191,0.01015351,0.045766167,0.018586058,-0.029753001,0.042047128,0.06857656,0.02489801,-0.007346354,0.051207572,0.07154396,0.061419867,-0.05614665,0.08508643,-0.026981888,-0.033126704,0.026238412,0.04418056,-0.046095584,0.023492085,0.044227496,-0.016265783,0.05445433,0.052061252,-0.050337803,0.025910996,-0.022675151,0.058198273,-0.11325989,0.05862381,0.031046769,-0.0918083,-0.004307886,0.05895001,-0.05622377,0.045081805,0.0050071403,-0.013453358,0.0151916165,0.025627702,-0.014899065,-0.04810462,-0.09548322,-0.11769331,0.04334782,0.026968474,0.047815394,0.04443231,0.014962081,0.102146894,-0.01642862,-0.04105047,0.02455483,-0.033019006,0.08341742,0.050658427,-0.042562623,0.0004394426,-0.006261055,-0.021690365,0.0046605063,0.0121156555,0.070074335,-0.051428724,0.013680769,-0.086790085,-0.030914415,-0.08030223,0.045381043,0.081894316,-0.014669667,-0.00907465,-0.0018311369,0.041502938,-0.012545392,0.015844857,0.0023242224,-4.7020144e-08,0.0297734,-0.05891931,0.107152455,0.037396025,0.03427381,0.06152621,-0.033062182,-0.029635739,0.011370255,-0.045147084,0.008246278,0.06008817,-0.0589921,-0.057245865,0.02402324,-0.0026110732,-0.08485281,-0.060025524,-8.773897e-05,0.04417359,-0.04330435,0.0017927425,-0.12511985,0.011899183,-0.0029890563,-0.075883746,0.02040751,-0.07369303,0.053699665,-0.07162694,-0.040924065,0.0501663,0.021148164,-0.006386875,-0.09570104,-0.08934146,-0.021254258,0.0052296286,-0.045007516,0.012676789,-0.050555408,-0.010633652,-0.09002311,-0.01661059,-0.0024393725,-0.0015553401,-0.01749758,0.020296957,-0.018166048,-0.019748272,0.011099619,-0.038922176,0.023286656,0.022300703,-0.116302155,0.06335263,0.027794097,-0.030306743,-0.07487831,-0.019243916,-0.010817623,0.059843548,0.0918441,0.044798955 +1.14.13.167,"Contains FAD. The enzyme catalyses the first step in a degradation pathway for 4-nitrophenol, the oxidation of 4-nitrophenol at position 4 with the concomitant removal of the nitro group as nitrite. The enzyme from the bacterium Pseudomonas sp. strain WBC-3 also catalyses EC 1.14.13.166, 4-nitrocatechol 4-monooxygenase.",384,1.0,-0.035497587,-0.011679217,-0.038530014,-0.014325279,0.11290403,0.049373757,-0.07522834,0.01958705,0.059445083,-0.06224672,-0.04322663,-0.016983174,-0.09977374,0.010306245,-0.082302034,0.056211535,-0.094451755,0.041234575,-0.026998388,-0.024486395,0.020238018,-0.011722395,-0.015339093,-0.031593982,0.017052004,0.08154744,0.025773983,-0.061819736,0.016224544,-0.031466898,0.026278764,-0.017058238,0.0857769,-0.0274814,0.058598775,0.023397638,0.048126053,-0.05842568,0.077289335,0.0022758746,0.016993271,-0.0008292406,-0.043653063,-0.023161937,-0.0054141413,0.01664343,0.030767148,0.006330971,0.06032719,-0.106939755,-0.050716724,-0.009581563,0.0013338864,0.053839244,0.041852545,0.044926643,0.019618895,-0.08735646,-0.0011800181,0.0836368,0.06703596,-0.057333913,-0.014478503,-0.01406841,0.02309627,0.011137224,0.04391671,-0.027635802,0.0060249874,-0.038096745,-0.048337802,-0.047759827,0.02057452,-0.037897184,-0.027683882,0.009069827,0.0470735,-0.042959463,0.059804667,-0.08369251,0.026926985,0.051878534,0.078705244,0.058231752,0.027595975,-0.042682067,-0.023798628,-0.043248124,0.040298205,0.12622972,-0.039325707,0.00093591074,0.038032774,-0.06265535,-0.029137174,0.09847902,0.010457954,0.015057049,0.059468664,-0.013363183,0.009413965,0.06114919,-0.027512893,-0.07019973,-0.08673817,0.038023714,-0.0075861043,0.16913055,0.048333224,0.037993066,0.025449352,-0.031963464,0.0063521788,0.004108667,-0.03900001,0.03751293,0.07778558,-0.04824471,-0.13226488,0.0055333027,-0.008189889,-0.05003149,0.05061745,0.013028246,-0.050834954,0.05029003,0.009756488,4.337429e-33,0.10057247,0.022793183,-0.056155343,-0.041200504,0.0072414535,0.027108286,-0.11864932,0.045535643,0.008115168,-0.061148893,-0.0034457517,-0.06882646,-0.059102647,-0.07040359,-0.012644006,-0.008661864,-0.05939232,0.021900566,0.051228438,0.013626209,0.03495186,0.0015027301,-0.07265803,-0.016970316,0.007775744,0.046292882,-0.013522283,-0.011777615,0.003614371,-0.014304583,0.005250796,-0.06689764,-0.1047532,-0.009223359,0.001127546,-0.020574974,-0.032995615,-0.0132450275,-0.02153315,0.10152351,-0.016554309,0.04921437,0.007401576,-0.044844337,0.081723206,-0.016884068,-0.024630543,0.1282537,0.03436361,0.14843133,-0.038419314,-0.025897503,0.06487841,8.422137e-06,-0.04167365,0.017944818,-0.017536953,-0.03855478,0.077042304,-0.045633994,0.033541113,0.061964404,-0.045758698,0.024258424,0.055655297,0.0063373134,-0.023135165,0.0021605473,0.002308232,0.08815416,-0.090891786,0.02467306,0.03285149,0.046094522,0.04201507,-0.089477725,-0.041861173,-0.0053629233,0.037309267,0.004180354,-0.034103904,0.027650796,0.026551219,-0.039621305,-0.037947707,0.05395807,0.0063573206,-0.05613777,-0.0130378,-0.04827063,0.0103297,-0.1213775,-0.059424195,0.02649297,-0.01325799,-3.488669e-33,0.10385026,-0.091261834,0.034605484,-0.062955305,-0.05797381,-0.0037389242,-0.037745886,0.012984432,-0.009626772,0.015199097,0.06717429,-0.01374455,0.047625378,0.02558886,0.03172363,-0.03624008,-0.0067705913,0.009254506,-0.051606894,-0.0036841498,0.047095537,0.055789925,-0.04625119,0.046245914,0.07285497,0.018659603,0.00975617,0.021801986,0.107910186,0.062407117,0.021039845,0.086886875,-0.021979962,0.021054018,0.030843638,0.019854179,-0.055135284,0.04447634,-0.006984784,-0.002505645,0.049877368,0.055633277,-0.040618476,0.053698476,-0.029983351,0.058723506,-0.1478075,0.04387901,0.07185399,-0.08084854,0.03859127,0.03886865,-0.06557486,0.040535975,0.016464245,0.015974052,0.030819632,-0.019486718,-0.06870851,-0.05106672,-0.10181751,-0.089214765,0.08941674,0.02036654,0.05030984,0.009949163,-0.024927929,0.13823734,-0.013981234,-0.021735191,0.029581623,0.01602402,0.04567089,0.06005045,-0.032544814,-0.03230232,-0.0034439215,-0.051607296,-0.0012555922,0.0127336,0.052954774,-0.011638691,-0.047552384,-0.10390465,-0.07664802,-0.082956634,0.03888793,0.12143087,-0.02464354,0.027092889,-0.013864188,0.053116046,-0.03522698,0.019144645,-0.018707862,-4.0401975e-08,-2.9743269e-05,-0.044882152,0.115725614,0.05602452,0.0032580325,0.06333046,0.009959685,0.01103772,0.051724683,-0.029841404,-0.035164215,0.0800578,-0.052599378,-0.06347764,0.018197306,-0.010291107,-0.08155717,-0.073307484,-0.016741522,0.0021023834,-0.077387035,-0.017291958,-0.06309091,0.023583895,0.01733973,-0.07321194,0.06504603,-0.017796118,0.027727006,-0.031841077,-0.025936823,0.05093513,0.028098458,0.0022356007,-0.06583627,-0.023579437,0.031052522,-0.022126129,-0.06008569,0.0085594915,-0.02428598,-0.043051552,-0.103808254,-0.03187291,-0.016663,0.008259949,-0.027936272,0.015295097,-0.030633312,0.021109922,0.05407185,-0.07431928,0.011355642,0.029019238,-0.116994835,0.04069034,0.012952759,-0.025852444,-0.05442254,-0.013273146,0.016779624,0.04137583,0.12790541,0.032403003 +1.14.13.168,"This plant enzyme, along with EC 2.6.1.99 L-tryptophan---pyruvate aminotransferase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.",384,0.99999994,-0.03028958,0.0014845511,-0.0922013,-0.0073297177,0.08875593,0.15801965,-0.04909043,-0.015040254,0.053832278,0.062200725,0.07866875,-0.056659434,-0.14032373,-0.04408463,-0.009537609,0.059499335,-0.10404966,0.004674117,0.015488365,-0.089780524,0.03638017,0.074116826,0.038194098,-0.029168867,0.06787926,-0.058861226,0.0017525785,-0.030264694,-0.00036216812,-0.044612918,-0.027376497,-0.025750538,0.012869065,-0.017001644,0.025206063,0.0755371,-0.034633387,-0.11430241,0.06858203,0.017885175,0.018136038,-0.00066206837,-0.044581722,-0.05824996,-0.019634366,0.052639525,0.046486992,0.024120074,0.015842587,-0.08525891,0.019245017,-0.06963511,0.0035197178,-0.026966942,0.014062392,0.018770473,0.0710812,0.04979102,-0.030949358,0.05302252,0.009564349,0.037353083,-0.02187328,-0.0041063516,0.012455052,-0.046647158,-0.03133192,-0.06803013,0.024446793,-0.024776189,-0.061933964,-0.09614057,-0.0065371487,0.051041227,-0.0085873315,0.041493326,-0.060057778,0.0152617935,-0.009578792,-0.065680824,0.024211658,0.014843417,-0.031139491,0.050237022,-0.017166339,-0.03636272,-0.0069770264,0.06898842,0.03254243,-0.014241093,0.03930762,-0.06457838,-0.018038426,0.014294524,-0.027318502,0.09973317,0.025645455,-0.07001727,0.008289266,-0.057865288,0.047035675,0.07990561,-0.079760045,-0.086201385,-0.03364128,0.023905484,-0.018760232,0.028807616,0.028521722,-0.0063584107,-0.044347934,-0.024875408,-0.00043868524,0.049820036,-0.055954676,0.044827178,-0.02055562,-0.043778874,-0.014284444,-0.013914012,0.059784703,0.014095395,0.028087746,0.13008662,-0.054576874,0.026476458,-0.09714656,7.8584975e-34,0.11184165,0.052638922,-0.001970203,-0.028133418,0.0033459156,0.0228839,-0.053928595,-0.025662122,-0.016939517,-0.060544837,-0.11875168,-0.15682217,0.030118065,-0.039337832,-0.037149888,-0.0066075735,-0.1318186,0.01032062,0.043583464,0.047342714,-0.051647708,-0.0015784984,-0.09886132,0.024692375,0.018429535,0.024601215,0.04549959,0.001459856,0.046392813,-0.041305758,0.0235635,-0.06185786,-0.041922536,0.017599152,-0.004490718,-0.069453955,-0.00458208,-0.04923221,-0.02097039,0.072042026,0.05477626,0.10382652,0.09011286,0.020158263,0.04211401,0.018295582,-0.026894098,0.088765055,0.1028336,0.09005893,-0.0013800007,-0.008448392,0.11975493,3.6201174e-05,0.021373503,-0.004182207,-0.029247379,0.020043636,0.035809968,0.032582738,-0.05652297,0.0069225654,0.006798631,0.012715864,-0.029331805,0.039300375,-0.0749029,-0.07695172,-0.0078081945,0.10759403,-0.08854992,-0.05580086,0.063646786,0.017004864,0.02002075,-0.03535538,-0.05276334,-0.0028291326,-0.05506011,-0.026749903,0.0038836144,0.0027575525,0.02197123,-0.005055307,-0.0069997017,-0.07766627,-0.053503517,-0.03175435,0.017839734,0.047643527,0.09992341,-0.0048705083,-0.035112713,0.06880331,-0.011905818,-1.3950135e-33,0.039766002,-0.0712062,0.019403111,-0.07508867,-0.046115194,0.027479421,-0.005551867,-0.06026122,0.023809632,0.00816959,0.076861456,-0.027305204,0.09948749,-0.020939454,0.07692014,-0.055803385,-0.015900008,0.1124504,0.005941613,0.03711519,-0.023718882,0.032525856,-0.01721749,-0.020253412,0.06670929,0.03773295,-0.026589584,0.068261795,0.0016352169,-0.0016436152,0.042489212,-0.052895926,-0.11283914,0.036539804,0.035045307,0.003468211,-0.050656565,0.012878595,-0.013363722,0.07033599,0.014877955,0.10013994,0.028012564,0.016126085,0.036172405,0.0045147333,-0.02463327,0.05149146,-0.016549058,-0.05343275,-0.0524109,-0.08587983,0.016484752,0.006030754,0.042184412,0.015141279,0.013630629,0.044879623,-0.007905918,-0.02678999,-0.02190758,-0.01575079,0.07814371,-0.007363918,-0.023053445,0.056477174,0.008369995,0.07135958,0.05773085,0.067754805,0.07149944,-0.023537282,0.044259235,0.07347879,-0.06600368,-0.05424379,-0.061083402,-0.029150825,-0.026000043,-0.037424438,0.043401882,0.044398833,-0.017014125,-0.049520034,-0.017604595,-0.031290703,-0.020681579,0.13714522,0.04622808,0.039078806,-0.026260143,-0.017578568,-0.04694014,0.08035552,0.09080035,-3.1578928e-08,0.026482027,-0.047757655,0.034109827,-0.01816471,0.020099036,-0.0458314,0.02072317,0.0146280825,0.0102884155,-0.076627254,-0.0010864894,0.043764103,0.0147669595,-0.009347565,0.038145714,-0.044255055,0.03926145,0.13365947,-0.018097365,0.02225801,-0.06337239,-0.011742949,-0.1056173,0.008520956,-0.0017597371,-0.033676818,0.042975962,0.081633545,0.05268658,-0.06116198,0.049671993,0.014828949,0.018557375,-0.044198476,-0.07691744,0.05364972,-0.032808945,0.012707501,0.033822346,-0.0029463544,-0.020144386,-0.08240761,-0.03192068,0.014264147,0.014281467,-0.015866015,0.028664779,-0.019044837,0.008126957,-0.0032417336,-0.011851725,-0.034064196,0.008721222,-0.07715478,-0.073602736,-0.034417197,-0.044482112,-0.031923495,0.015315237,-0.06595765,-0.02407683,0.04957226,0.15697801,0.010005284 +1.14.13.169,The enzyme is involved in the biosynthesis of sphingolipids in yeast and plants.,384,1.0,-0.08871475,-0.024303816,-0.12810764,-0.020342933,0.050164137,0.07718714,-0.058873072,0.032691333,0.030164387,-0.018388335,0.085927784,-0.06161517,-0.11435191,-0.022516198,-0.025008857,0.05843167,-0.10083452,-0.0004980609,0.030059377,-0.071115516,0.05470552,0.008621621,-0.063366406,0.07127304,0.012388563,-0.01311477,-0.015236841,-0.061539523,-0.018675547,-0.016321503,-0.025116876,0.032997824,0.06695374,-0.0757304,-0.0044631045,0.103826255,0.02628381,0.04120918,0.10290118,-0.013398027,0.030291388,-0.037052676,-0.06276512,-0.025150804,-0.04830009,0.048550267,-0.019334093,0.0627278,-0.007049904,0.0019643074,-0.062312372,-0.021026157,-0.03036173,-0.054267015,-0.011866553,0.005177357,-0.030895762,0.03583565,-0.065333255,0.02322169,-0.010345179,-0.0374155,-0.03425096,0.092379995,-0.044182725,-0.12755065,0.02725619,-0.032380056,0.040193878,-0.01140169,-0.01945849,-0.095974684,-0.042964276,0.018276906,0.02561471,0.09070475,0.01317878,-0.02646673,0.030721288,-0.01943275,0.07122656,-0.011664085,0.023347469,0.07201801,0.04246917,-0.021431554,-0.0029240635,0.048607215,0.029603142,0.053613972,0.02768306,-0.03196414,3.2818265e-05,0.07144434,-0.07410666,0.11838587,-0.025608024,0.01531271,-0.009793803,-0.028368423,0.010552391,-0.0006124814,0.04078007,-0.055009972,0.023040466,0.019630233,-0.029462704,0.022631653,-0.0212142,0.04788663,0.03397115,0.00048359248,0.07308796,0.005102677,-0.007952231,0.02933139,-0.0019395185,-0.026399314,-0.026363425,0.006499508,-0.012580375,0.041865338,-0.04066312,0.035440516,-0.051859666,0.014721989,-0.06995619,-3.092984e-33,0.043102663,0.01141862,-0.019634021,-0.00850737,-0.06008466,-0.04785749,-0.037456084,-0.033812385,-0.07509734,0.029141964,-0.047225118,-0.117265366,-0.012882365,0.05892715,-0.0093739955,0.013866616,0.025892394,0.014790443,0.08720098,0.053128604,-0.05265131,-0.016890913,-0.09227585,-0.0626035,0.069339976,0.059896853,-0.068266936,-0.02362436,0.0048382157,-0.026019804,0.0499507,-0.06353346,-0.0798048,0.043838743,0.08160215,-0.021011207,0.020383062,-0.03945532,-0.047698595,0.03554518,-0.0343763,0.030052643,-0.013444645,-0.03758604,0.012044354,0.06498455,-0.06652754,0.03325191,0.10811323,0.06058778,0.005025037,-0.010351919,0.14348423,0.10831471,0.033600394,0.044841215,-0.007617322,0.018411748,4.732143e-05,0.025840055,-0.080675244,0.09208812,-0.029594528,0.03913496,0.05599812,-0.04902493,-0.07089936,-0.023919195,-0.060119152,0.030011503,-0.02806373,-0.005484121,0.02299876,-0.02344464,-0.006259975,-0.053828448,0.023974342,-0.011264502,-0.035875447,0.04678481,0.040918604,-0.06305206,-0.011137285,-0.03575915,-0.08151145,0.0320896,-0.043565307,-0.0062883864,-0.001965946,-0.06458496,-0.004792536,-0.062280316,-0.054424617,0.04370917,-0.043184254,-3.7832994e-34,0.021158578,-0.068634145,0.075079426,-0.10617577,-0.08569658,0.112179734,0.035733595,-0.032199826,0.0034711594,0.021157961,-0.05932571,0.017205361,-0.029165322,-0.03098584,-0.05242657,0.04604723,-0.018053936,0.01882579,0.026002211,-0.016593078,-0.011385052,0.14517593,-0.056069136,0.11068728,0.028122917,-0.016063906,0.01962749,0.07351303,-0.023641838,0.0034316087,0.0018269003,-0.07766994,-0.054741364,-0.006527303,0.020788094,0.010397215,-0.036477935,0.055399023,0.015499918,0.024260206,-0.04195683,0.064329535,0.024153754,0.005086376,0.08525381,0.087499894,-0.09155729,0.04279822,-0.04182582,-0.054846216,-0.040477164,0.05707379,0.04420743,0.051112693,0.010347273,-0.040841114,-0.0056131007,0.0441166,0.0043096514,-0.082056776,-0.024867613,-0.07784479,-0.044798262,0.0401708,0.006186463,0.105824456,-0.06455983,-0.009134358,-0.010164413,-0.017110351,0.006833768,0.03724854,-0.05229244,0.074550405,-0.02182085,-0.017702626,-0.056726914,-0.12045867,-0.0054888846,0.025043245,0.05516455,0.011970798,0.06802587,-0.024553398,-0.0035801798,-0.019379504,-0.010901421,0.033972126,0.053019788,0.007324548,0.01341686,0.013422329,-0.044137046,0.035482187,0.06008971,-2.1896103e-08,0.08205985,-0.036484625,0.060296528,-0.108313106,-0.05623594,-0.027631342,0.043483015,-0.007847102,0.048458297,-0.019387243,-0.108301096,0.07075058,0.0312809,0.07477842,0.10830448,0.013445601,0.014259314,0.013527458,-0.028308205,-0.036233414,-0.002103436,0.0035718519,-0.1179211,0.043111116,0.036652602,-0.060988758,0.0629766,0.029878987,0.023466403,0.03817546,-0.010471872,0.0020525772,0.009514737,0.021658555,0.022971207,0.027261913,-0.056079518,-0.07919624,-0.01083361,0.051398337,-0.0065514036,-0.058763165,-0.008649818,-0.030775853,-0.06655723,-0.012469386,0.034417786,0.024487233,0.08761327,0.049370393,0.023376891,0.06779281,-0.05892842,-0.048811935,-0.10229665,-0.040198043,-0.031027514,-0.021101877,-0.0014640108,-0.06663393,-0.01976556,0.04589358,0.18864061,-0.0679264 +1.14.13.170,A FAD-dependent oxygenase. Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. The ketone undergoes a biological Baeyer-Villiger reaction. Part of the pathway of pentalenolactone biosynthesis.,384,1.0,-0.08069925,-0.0014909179,-0.09248678,-0.0069828774,0.0493004,0.03949651,-0.101563744,-0.0029707903,0.0902491,-0.024310578,0.033178564,-0.041191567,-0.073033966,0.03283881,-0.053388096,0.052953944,-0.087699555,0.05667596,0.0034336993,-0.026248071,0.07194506,0.08134207,0.05246673,-0.0844624,0.039850883,-0.004611797,-0.0017150405,0.001810599,0.00508022,-0.08902906,0.039664418,-0.06028571,0.06323187,-0.09439895,0.11798534,0.07160039,0.01326245,-0.026713822,0.073737666,0.05733545,-0.01627454,-0.005706982,0.016540304,0.0015418155,-0.05260782,0.044331133,0.020955006,0.015614128,-0.041227728,-0.044391666,-0.052085,-0.09580943,-0.07198244,0.0044481317,0.048168097,0.022073885,0.0052129077,-0.09818841,0.0226004,-0.049426828,0.075623035,0.012332874,0.00830706,-0.009906897,-0.1079843,-0.017517023,0.0339837,-0.04704205,0.03781111,-0.060848765,-0.03053449,-0.04102967,-0.034202375,-0.0006376575,-0.014276623,0.060267515,-0.035416957,-0.062254865,0.03232118,-0.012546114,0.10172721,0.018832915,0.018752815,0.06843248,0.05941099,-0.061782394,0.0016752757,0.01741199,0.03588806,0.05159886,-0.025686534,-0.060960863,-0.03174386,-0.052086845,-0.07277914,0.013478757,0.016019916,0.054930747,-0.0017396805,0.0045601204,-0.06609049,0.0041469433,0.014309545,-0.01048579,-0.012133812,-0.03946465,-0.0096868165,0.047307353,0.023032036,-0.024941351,0.010690666,-0.027163986,0.0051815137,-0.04720268,0.01450752,0.026788212,0.010023302,-0.0654621,0.0013947895,0.014545437,0.0014851778,0.05261269,0.024179896,0.03743669,-0.0078062224,0.0065744976,-0.10000194,3.642654e-33,0.06834267,0.030664034,0.017689912,0.0026889879,0.026535569,-0.040609237,-0.09114121,-0.05237793,-0.029536279,-0.06277059,-0.07770395,-0.024704484,0.018676426,-0.023052054,0.016684394,-0.011101846,-0.036913015,0.0029744753,0.051922925,-0.06804436,0.030755024,0.068209164,-0.061083797,0.042177357,0.01999623,-0.0076801367,-0.036118586,0.012874183,0.13329278,-0.017565394,0.06364112,-0.06647193,-0.0711434,-0.04355601,0.052514184,0.007835008,-0.090262026,-0.05331969,-0.020803016,0.02609558,-0.005619336,0.06331315,-0.060118247,-0.0027670066,0.06897719,-0.026697248,-0.07321395,0.10084165,0.09743524,0.035704046,0.036164675,-0.023450576,0.096257865,0.03995626,-0.05917315,0.011987172,-0.047940537,0.016582806,0.06267835,0.016468339,-0.01577733,0.059766144,0.040690824,0.053153463,0.021465763,0.031933125,-0.054732796,-0.029611178,-0.019740313,0.029346617,-0.044541724,-0.019931395,0.054591756,-0.06509014,0.015891446,-0.053192955,-0.055461388,-0.051012553,-0.06344918,-0.028486492,0.030239927,-0.027675938,-0.011400934,-0.08448081,-0.040563162,-0.019260036,-0.0832256,0.0053342395,0.030513702,0.06183403,-0.005410837,-0.060090836,-0.059056345,0.026374215,0.057241246,-3.1782634e-33,0.10625801,-0.067357935,0.1274742,-0.08257349,-0.04378402,0.13106942,-0.02084082,0.020266345,-0.039765637,-0.0011913882,-0.02388042,0.014380626,0.06697508,-0.023467334,-0.01189607,-0.021974295,-0.0073736575,0.09905303,0.034070104,0.036166687,-0.01469718,0.07071599,-0.03576415,0.014402798,0.03294176,0.067414574,-0.055045113,0.07983949,0.0031275002,0.017926006,0.032852083,-0.018020794,-0.021974726,-0.025903137,-0.07367792,0.06286982,0.004525158,0.006801605,0.0032074647,0.035729025,0.010008273,0.0064270115,0.013548245,0.13760948,0.06697282,0.08350256,-0.052513443,0.020550312,0.008425218,-0.07752351,-0.02716014,0.02158226,-0.111326285,-0.01684993,0.026815709,0.023304863,0.0570079,0.036369577,-0.014824106,-0.032458775,-0.00073188863,-0.076636404,0.04618382,-0.0044300808,0.10491724,0.09268349,0.04733242,0.11900841,0.05044868,0.024241004,0.026703488,0.093310736,-0.0333742,-0.018969778,0.08647127,0.05235181,-0.06740067,-0.059263736,-0.035078105,0.007056593,-0.013785933,-0.05697446,0.041368175,-0.04307965,-0.034418985,-0.04929435,0.06663746,0.05641229,0.0013271876,0.031027894,-0.019460369,0.036240276,0.002509494,0.06474196,0.08893215,-3.424153e-08,0.03418932,-0.008073764,0.086820476,-0.01776289,0.017130246,-0.006049243,0.029318102,0.0043023876,0.0637241,-0.014518716,-0.061309848,0.019083606,0.053539265,-0.06365451,0.084929146,0.012527458,-0.03668046,-0.008217342,-0.037244964,-0.020900954,-0.04233976,0.051841937,-0.016296336,0.0646735,-0.032321762,-0.077744864,0.045787413,0.005228843,-0.049682193,-0.025808398,0.0385431,0.03866402,-0.0037630158,-0.013905909,-0.120554164,-0.037426606,-0.021982176,-0.055293113,-0.040961385,-0.006126436,-0.02280073,-0.059402283,-0.07446973,0.0039397716,-0.03991855,0.09286041,0.021801492,-0.060357057,-0.06065582,0.0025120168,0.01148024,0.01948838,0.0018998857,0.015367853,-0.12391044,0.040148783,-0.010223401,0.011841182,-0.055468384,-0.04050604,-0.054315954,-0.044865888,0.19218665,-0.014337934 +1.14.13.171,A FAD-dependent oxygenase. Isolated from the bacterium Streptomyces avermitilis. The ketone undergoes a biological Baeyer-Villiger reaction.,384,1.0,-0.10418712,-0.008663742,-0.09135821,0.0054319473,0.060171004,0.06282189,-0.11286023,0.016802303,0.06591971,-0.040621053,0.019537937,-0.05301179,-0.02722015,0.034742147,-0.07713403,0.046740573,-0.059853613,0.02476972,-0.006687706,-0.035402015,0.039494358,0.1035224,0.09280595,-0.070591465,0.027789284,0.0076514552,0.0065159965,0.0051550027,-0.0051063234,-0.06752449,0.07203041,-0.054241754,0.08928352,-0.084449366,0.09859738,0.05836707,0.029220983,-0.02160219,0.06427237,0.023831127,-0.03590048,-0.004291776,-0.0199702,0.037456837,-0.05715109,0.037009794,0.039235488,0.0033370086,-0.015802037,-0.06526302,-0.036046263,-0.060062602,-0.09316708,0.007606328,0.024044784,0.0059984014,-0.02375786,-0.10425439,0.0064103235,-0.06192389,0.04008977,0.018297236,0.04833555,-0.0043215235,-0.097258605,-0.022466548,0.024488535,-0.047215745,0.042133253,-0.03692855,-0.041859023,-0.05889099,-0.051170375,-0.0045149485,-0.018115526,0.009109935,-0.012667297,-0.069826275,0.06411322,0.02073251,0.06506241,-0.02742295,0.021606714,0.08216233,0.036483575,-0.066739365,0.023090389,0.003250815,0.039182585,0.052994568,-0.010182362,-0.06809311,-0.022848077,-0.04795487,-0.048148468,-0.022229757,0.0064677065,0.05494182,0.020788185,0.010106242,-0.073935024,0.005113508,0.013210395,0.018283715,-0.014155634,-0.047120105,-0.0029775875,0.06947255,0.057697598,-0.047606587,0.033517133,-0.017765317,0.010422397,-0.040035985,0.0068616173,0.027457282,0.027837224,-0.05744973,-0.006536857,-0.0074841394,-0.007110473,0.041294266,0.020543598,0.01950482,-0.021152947,-0.0025727984,-0.1314409,9.115974e-34,0.056986183,0.014510389,0.02426658,-0.027516333,-0.020293856,-0.030764516,-0.11719606,-0.033696197,-0.025497135,-0.04166326,-0.04860906,-0.045518227,0.010497337,-0.005329307,0.04255318,-0.016237905,-0.050029293,-0.0009488359,0.04706567,-0.1077225,0.020444054,0.034761686,-0.01996196,0.03632536,0.054909594,-0.019443134,-0.004086916,0.017694565,0.13282463,-0.013015866,0.05129428,-0.05602155,-0.07714813,-0.011482593,0.030653989,0.017231155,-0.11000032,-0.030118272,0.010069973,0.013613138,-0.018920746,0.070202544,-0.047012106,-0.02621469,0.07493626,-0.041843127,-0.06576333,0.120619886,0.09712789,0.06112455,0.017888598,-0.06746923,0.083239675,0.021263137,-0.066842765,0.033685144,-0.022074193,0.046795912,0.06778513,0.006754202,-0.035104465,0.06343359,0.07545401,0.0643244,0.047201965,0.028417762,-0.037071444,-0.036898326,-0.027437814,0.052523445,-0.03604044,0.03850902,0.041580655,-0.09474243,0.008214845,-0.049808286,-0.06852651,-0.055349212,-0.0029177514,-0.017514536,0.062511675,-0.042993993,-0.008005761,-0.08460211,-0.041948695,-0.0091761565,-0.08894022,0.005673347,0.027775208,0.06717335,0.03298696,-0.06829171,-0.049030274,0.019366568,0.047414612,-1.3152295e-33,0.12833491,-0.07467304,0.12396537,-0.06253899,-0.0368688,0.1130935,-0.011265916,0.017650798,-0.03151186,-0.004993727,-0.016728742,0.01792678,0.07431886,-0.046882045,-0.0038881141,-0.01248061,-0.012269254,0.070929475,0.042483382,0.038585894,-0.0076085683,0.053668946,-0.032516964,-0.01470602,0.0040852483,0.057788372,-0.044984538,0.07752016,0.028465772,-0.0055453973,0.059663057,-0.028052261,-0.016828207,-0.048876442,-0.03673547,0.05504306,0.01653244,0.029016588,0.02786023,0.005282307,0.026303986,0.04053185,0.021318262,0.10454694,0.069584936,0.09213351,-0.049889773,-0.016436338,0.00894002,-0.11654996,-0.039308798,0.005704867,-0.10458927,-0.031252522,0.025115214,0.029652761,0.05551721,0.01284951,-0.03461658,-0.058971882,0.0025007476,-0.07177733,0.06582264,0.0038297463,0.017053071,0.10329685,0.06479576,0.07603487,0.059824247,0.010419229,0.051717594,0.052492443,-0.047052253,-0.027716493,0.08055423,0.0334503,-0.038868926,-0.008758375,-0.006463784,0.018611873,0.0029961118,-0.04307987,0.03095805,-0.0448942,-0.03287928,-0.07060778,0.03766981,0.053854015,0.002787263,0.034752104,-0.031234551,0.038829025,0.019235592,0.03228837,0.08811483,-2.8448627e-08,0.033255517,-0.028959606,0.112930015,-0.013947328,0.04807326,0.02474727,0.040565245,-0.019470569,0.048054796,-0.02153068,-0.06253709,0.019721255,0.05379894,-0.077830024,0.0772822,0.0018757797,-0.06350138,-0.015121614,-0.021169309,-0.026913296,-0.028899366,0.047180757,0.010919314,0.049807116,-0.04285678,-0.03860105,0.037392743,0.005292659,-0.055194378,-0.02287975,0.017163001,0.080237485,-0.026873121,-0.019450434,-0.1259736,-0.07006964,0.00407766,-0.06746235,-0.040728822,0.0051418864,-0.0034039905,-0.02318989,-0.06338433,0.010842794,-0.03100591,0.07697062,0.041962154,-0.08738627,-0.07750177,-0.004962354,0.06527012,0.044765744,-0.013794584,0.038688798,-0.1329406,0.06680134,-0.034704763,-0.020066604,-0.08473508,-0.03994442,-0.02618998,-0.07452765,0.13147944,-0.030172683 +1.14.15.11,"A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis.",384,0.99999994,-0.018017221,0.040776256,-0.09220377,0.00026332878,0.012905954,0.053568948,-0.009228725,0.08913187,0.054848194,-0.03741957,-0.0034848836,-0.010689975,-0.11542608,0.0109489765,-0.055953987,-0.024036495,-0.034102518,-0.046509154,0.058282852,-0.050889425,0.072359934,0.08902171,0.013598167,-0.042863857,0.035396416,0.02919195,0.050149366,0.0361086,-0.02937234,-0.08745048,-0.009853106,-0.03966978,0.046129774,-0.08912728,0.076565385,0.111398585,-0.082056575,-0.014761745,0.05673884,0.028839901,0.0651153,-0.06455962,-0.029743541,0.011763905,-0.06393084,-0.0015203892,0.00079384004,0.073274285,-0.034288313,-0.016642483,-0.0353031,-0.044117484,-0.041843273,0.044573117,-0.0045471573,-0.04974436,0.12558262,-0.033440035,-0.0042049307,-0.08306432,0.06909966,0.07138658,-0.014889644,0.00051282067,-0.08329543,-0.014738512,0.068933666,-0.024567002,0.04129988,-0.0718292,-0.024014324,0.025739808,-0.05699213,0.022666417,-0.04581277,0.056666456,-0.050800826,-0.027285757,-0.004794725,0.016555041,0.08048853,0.07066746,-0.028717883,0.088255025,0.04229011,-0.017913876,-0.031155178,0.06218809,0.032017738,-0.04419276,0.0015695677,0.033487055,-0.045889508,-0.0027136572,-0.13456611,0.027771393,-0.027744357,-0.008575104,0.00472967,0.0006808311,0.03362564,0.051265206,-0.009578969,-0.05664706,-0.062479537,0.041342724,-0.03923875,-0.024046112,0.111047894,-0.020119099,-0.0696667,-0.0015084156,-0.018486187,-0.047715496,-0.020656189,0.047384303,-0.019302556,-0.023841383,0.04276178,0.00639832,-0.001353499,0.0064372593,0.026861953,0.055765167,0.0017396882,0.03345587,-0.0706581,1.5437833e-33,0.06278056,0.054382473,0.040033527,0.0009386732,0.014249122,-0.0054559195,-0.07525474,-0.019195972,-0.07636184,-0.032966405,-0.076440476,-0.12931979,-0.0086115375,0.010692493,0.019034162,-0.011320049,-0.039890192,0.046028525,0.09891355,0.0098040365,0.0010569451,0.05978973,-0.08247664,0.029496526,-0.0064026755,0.05417492,0.029227396,0.05010502,0.0918228,-0.003331626,0.06188325,-0.04536202,-0.0048635667,-0.10672818,0.03287535,-0.044847418,-0.06881698,-0.041674275,-0.030891795,0.06356595,0.038724422,0.028042445,0.076284416,-0.02247046,0.10612894,-0.045692023,-0.12058796,0.045156665,0.042201836,0.0138378395,-0.0027548394,-0.0050917645,0.12487499,0.052418653,-0.070604116,-0.019840112,-0.037584297,0.06714433,0.06298234,0.04887497,0.111514375,0.13519444,-0.01692058,0.006276712,-0.035166778,0.06795728,-0.040903393,-0.0072273305,0.0012443985,0.059839007,-0.05622359,-0.039395466,0.0036340074,-0.04721135,0.027287519,-0.043384932,0.016181607,0.007468036,-0.016945753,-0.031229924,-0.029826827,-0.037379216,-0.020189976,-0.0686308,-0.06772159,-0.04086367,-0.044385485,-0.004582221,-0.022508418,0.034967363,0.0036898437,-0.045637693,-0.098110385,0.047498975,0.0010679433,-1.3221953e-33,0.047374535,-0.07701163,0.08986308,-0.07207725,-0.05734965,0.079443805,-0.023134617,-0.00090005115,-0.08289264,0.015150885,0.017432353,4.078162e-05,0.008488058,-0.059375875,0.040904902,0.031370733,0.02139425,0.06813163,-0.005329063,0.05831249,-0.030780783,0.046721574,-0.0065032747,-0.019351166,0.047715086,0.036244333,0.0531781,0.001525769,0.0324436,-0.019774027,0.03293875,0.021352446,-0.05211823,-0.037229437,-0.12832184,0.03860454,0.003027207,-0.05062915,0.034484327,0.07395262,-0.008250253,0.048419777,0.030227616,0.07770658,0.034847543,0.0698371,-0.08829267,-0.016887898,0.041629035,-0.008549339,-0.0029190816,0.041195367,-0.0059192805,-0.018968763,0.027836904,-0.05790789,-0.023681138,-0.013122005,-0.016279815,-0.088276796,0.005122756,-0.0102404915,0.019045502,0.008305028,0.10528046,0.06983136,-0.02311111,0.1116171,0.035217024,-0.01342014,0.015046753,0.09205095,0.007830118,0.03417566,0.022335354,0.029365417,-0.042898178,-0.04899596,0.0005684563,0.014922269,-0.012940393,-0.06490431,-0.013789442,-0.082451165,-0.046404,-0.10770325,0.018784806,0.0858943,0.022455016,0.0564,-0.04380122,0.032355633,-0.035544112,0.07290423,0.07091485,-3.135658e-08,0.012174485,-0.059700225,0.021217525,0.013138523,-0.010716587,-0.04999495,0.037137836,-0.05549518,0.050644536,0.00959633,-0.053893257,-0.011863937,0.02115938,-0.007352029,0.03768426,0.039941896,-0.00018458658,-0.0013901134,0.0077703395,0.034782134,-0.026553165,0.051528413,-0.03931425,-0.00048709594,0.019302262,-0.08192118,0.035431407,-0.035466272,0.013758322,-0.0017840647,-0.008914047,0.051925924,-0.049439367,-0.00019883498,-0.023932861,0.0616718,-0.076558374,-0.019077461,-0.051685385,-0.028843261,0.033099066,-0.07867435,-0.058928438,-0.009092841,-0.015999226,0.013152609,0.011235012,0.024501111,-0.057031423,-0.042232797,-0.024953973,0.026700348,-0.0018327681,0.00038780583,-0.115935706,0.026956264,0.016933564,-0.0406975,-0.0528806,-0.110654436,0.025390696,-0.050596546,0.22987635,0.031957664 +1.14.99.47,Isolated from the plant Larrea tridentata (creosote bush). The enzyme has a strong preference for the 3' position of (+)-larreatricin.,384,1.0,-0.04798386,-0.113061465,-0.11692024,-0.028066752,0.07439154,0.09526503,-0.11178356,0.040193517,0.01745533,-0.0041828146,0.11685803,-0.09184106,-0.07860031,-0.009640749,-0.037446525,0.022335578,-0.063706286,-0.015905207,0.07312522,-0.049708564,0.078927144,0.04679771,-0.014381088,0.05421424,0.033182934,0.03646983,-0.032208923,0.010985196,0.03414862,-0.0575556,-0.058060773,-0.039162233,0.01441684,-0.06230155,0.013105971,0.049384218,-0.05499502,-0.11160649,0.097876415,0.06863477,-0.01304861,-0.027778825,0.044768866,-0.07474106,-0.06977618,-0.03589665,-0.06664998,0.04903135,0.10989324,-0.043329567,0.022762261,-0.09299796,-0.08746391,0.070324585,-0.036829565,-0.025524804,0.0010435112,0.04426034,0.03184789,0.096777305,0.10024741,0.07613453,0.014506948,0.0073887194,0.025638213,-0.05411814,-0.03390936,0.031080134,0.02663573,0.013768292,0.006801005,-0.07006435,0.020259239,0.041596647,-0.0067846286,0.023664342,-0.0077945157,-0.05843,-0.010711707,-0.019501032,0.034947563,0.025652908,0.025999727,0.11217659,0.0121933315,-0.0011095059,-0.04575208,0.08058533,0.024241714,0.025171706,0.06423564,0.051907826,-0.0667966,-0.055642497,-0.018656038,0.07252181,-0.033020414,-0.0067011765,-0.038138095,0.0068071405,0.014848633,0.020188522,0.025410056,-0.0673574,-0.04689927,0.08112813,-0.11531138,0.007006573,0.047229066,-0.016820751,-0.015135211,0.04470647,-0.04394823,-0.016626596,-0.06161818,0.06736977,-0.0059505524,-0.059820395,-0.0484461,-0.0015525342,0.0289383,-0.05913865,0.06537614,-0.010257765,0.030096907,0.032649588,-0.093410715,6.391605e-34,0.08749446,0.0009603998,-0.019430168,-0.095185935,-0.044961207,-0.0394632,-0.06784051,0.08758661,-0.11436132,0.0018758157,-0.05229888,-0.03561925,0.037213158,-0.0025616076,6.525932e-05,-0.050853875,0.017146822,-0.036745682,0.027981149,-0.005525091,0.03356687,0.06612716,-0.051415168,0.023661328,0.012983084,0.0040304074,-0.0038426276,-0.013147311,0.03520957,0.013418671,0.017911548,-0.100317895,-0.05747885,0.036138576,0.07294907,-0.035077676,-0.061382093,-0.123094164,-0.031044759,0.06779587,0.078025855,0.06204987,0.084563784,0.006134975,0.08096682,0.0020515043,-0.029905561,0.025827365,0.11173086,0.020611865,-0.00016728259,0.02813426,0.02803856,-0.04316156,-0.08439468,0.02920841,-0.04723656,0.061178237,0.035174403,0.02232049,0.019800289,0.056969717,0.02620749,-0.032268852,0.024346778,0.03516731,-0.09036656,-0.09097334,-0.0024733334,0.0030841294,-0.04499043,-0.066511996,0.019936357,-0.014202292,0.073548764,-0.03174467,0.030427147,0.047611598,-0.050171033,-0.04474955,-0.094585985,0.007107858,0.06973885,0.07027269,-0.025536649,0.014886533,-0.020106437,0.028955927,0.027484981,-0.0003021905,0.04618985,-0.05436952,-0.057574365,-0.033734214,-0.0397204,-5.8116073e-34,0.015724597,-0.06301931,0.04587891,-0.064302646,-0.086850226,0.08863299,-0.027060147,0.035588246,0.006055535,0.037172172,0.056242704,0.046024714,0.01389062,-0.079976894,0.06371741,0.066784225,0.006701511,0.051525053,-0.042290397,0.011006618,0.02653492,0.072955504,0.081377916,0.013243644,0.040372364,-0.020746723,0.034987435,0.013468987,0.0084507875,0.008517797,-0.022067854,-0.0016151876,-0.051695835,-0.033866234,-0.13274047,0.007975006,-0.12621279,-0.04991506,0.033247888,0.1173738,0.030519813,0.06614028,0.02750774,0.06696871,0.040312275,0.008903364,-0.05920319,0.02711391,-0.016019017,0.039093316,-0.004029317,0.027617555,0.023465604,-0.05028755,0.045013223,-0.030758671,-0.0062063048,0.014961223,0.005471514,-0.010581475,0.058326483,-0.0016324716,-0.05315988,-0.013693218,0.10135058,0.10366815,-0.03593507,-0.0019470722,0.006054122,0.012004614,0.08812337,0.0023247509,-0.006836739,0.043399997,0.005367484,-0.012285588,-0.070481725,-0.07161287,-0.030848257,-0.014215479,-0.009195612,0.0020985622,0.025497908,-0.060910873,0.034024633,-0.046061393,-0.0063081826,0.08273248,0.06790952,0.038455922,0.00050835963,0.04074282,-0.072543286,0.009351177,0.0833748,-2.7481722e-08,0.0587888,-0.03849787,0.0358013,-0.019488243,0.013824414,0.0007328779,0.019769954,-0.03713762,0.016017063,0.04498672,-0.05677958,-0.0038830102,0.004715686,-0.024164751,0.007763693,0.01568043,0.015032059,0.06562801,-0.07731857,0.0366286,-0.021747075,0.038453378,-0.016621597,0.017148463,-0.0067380704,-0.034046926,0.03109765,0.05638144,0.00999431,0.017237717,0.021942208,0.03972752,-0.04080517,-0.08613873,-0.06453551,0.07158848,-0.035699893,0.028459184,-0.07060824,0.022172749,-0.0151242465,-0.07381367,-0.013319811,0.0408534,-0.011131049,-0.0019027644,0.02844516,0.009925917,0.06806483,-0.039200988,0.0407787,-0.09245241,-0.012541628,-0.05408128,-0.06457227,-0.057523247,0.00105496,-0.0780567,-0.029437639,-0.04714755,-0.058703814,-0.017011408,0.13873297,0.02858256 +1.18.1.6,"A flavoprotein (FAD). The enzyme, which transfers electrons from NADPH to adrenodoxin molecules, is the first component of the mitochondrial cytochrome P-450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones.",384,0.99999994,-0.104150265,-0.047128957,-0.12050463,0.0039704475,0.10091968,-0.003238597,-0.006925185,0.052620303,0.034258407,-0.037114963,0.046261273,0.037328955,-0.0985548,-0.020649554,-0.051503386,0.011303908,-0.076814674,-0.0053080204,-0.016914658,0.005256873,-0.0012357064,0.013952971,0.04705042,-0.073009685,0.041934308,0.005534338,-0.02040022,-0.022176312,-0.022275014,0.01288841,0.062038373,0.031585287,-0.016507264,0.0048883553,-0.07660091,0.090739325,0.040173978,-0.024957918,-0.03509163,0.03869294,0.03429874,-0.028605903,0.018821398,-0.009263336,0.04846129,-0.00094432454,-0.010506271,0.069679484,-0.009155074,0.011148199,0.026149184,-0.029460248,-0.07123108,0.06461025,-0.021682903,0.06761064,0.027814783,-0.09457313,-0.0420203,0.0011693041,-0.031802073,0.01455271,-0.021439156,0.033770442,0.094086386,-0.06617863,-0.037217565,-0.024903987,0.014691608,-0.057817638,0.0004530717,-0.046263076,-0.05237952,0.01806085,0.008944468,0.054374427,-0.09844361,-0.03986463,0.057460334,-0.008687141,0.0965186,-0.025395786,0.044096615,0.0968767,0.07410293,-0.009427596,0.010428276,0.0034173022,-0.09525012,0.051333483,-0.02556406,0.006562304,-0.008040617,0.053029504,-0.10288594,0.077644005,0.04889358,-0.022195555,-0.07401866,0.002796688,-0.028412102,0.0683206,0.026886059,-0.020789878,-0.06968682,-0.081973426,-0.024058511,0.09121928,-0.03659403,-0.03387619,-0.017479146,-0.024576899,0.019182276,-0.06342542,0.031431407,0.05150581,-0.06330304,-0.04179738,-0.010901504,-0.013862978,-0.048635785,0.09606665,0.0027511239,0.109371714,0.081660606,0.010539383,-0.09897423,1.9448793e-33,0.12425522,0.014174562,-0.026931861,0.010326151,-0.021355933,0.025012618,-0.065270066,-0.0045306413,0.036814503,-0.02675816,-0.040537015,-0.012295319,0.0053242883,-0.017212583,0.028037228,-0.016843475,-0.05093839,-0.030216062,0.14295143,-0.1035121,0.050548512,0.07360914,-0.022267468,0.033476725,0.01807604,0.0051962812,-0.11924026,0.0537706,0.0020284962,0.034970302,0.00388472,-0.050873555,-0.06903702,-0.0055357832,-0.041760247,0.02750887,-0.0851702,-0.11084837,-0.09489104,0.06253286,-0.005340512,-0.047883667,-0.0063960035,0.0036329285,0.010603988,-0.046740826,-0.08210607,0.039962135,0.0036975208,0.101903826,0.029658517,-0.058220178,0.11362361,0.049768757,-0.07975894,0.025588844,-0.049485907,-0.032643076,-0.035233904,0.027931811,0.028682504,0.07408673,-0.009700768,0.113818645,-0.045731556,0.01872912,0.01617436,-0.10144707,-0.007827914,0.13029483,-0.01923386,-0.008303921,0.08049264,-0.0014456267,0.084660895,0.015964322,-0.018597955,-0.044756852,-0.047523107,-0.02217647,-0.032498308,-0.041192766,-0.047581427,-0.010652998,-0.011138517,0.020805836,-0.00071091997,-0.04922888,0.0111520635,-0.013121532,0.042331442,-0.047736667,0.009977459,-0.01239633,0.029916834,-1.9016316e-33,0.03089062,-0.10378018,0.087980844,-0.023777047,-0.0017170788,0.06324547,0.04459723,-0.023397563,0.062871,0.011780085,0.015554885,-0.045861702,-0.034187943,-0.020037325,0.068482995,-0.0174636,-0.07506901,-0.029755842,0.05971855,0.043534707,-0.035170842,0.06363031,0.070371166,0.09460141,0.06566589,-0.02986604,0.020234052,-0.06688796,0.03640406,0.0069861705,-0.038766716,0.02628378,-0.050092086,0.0036684456,-0.065101355,0.05647451,-0.0010925113,0.031570878,-0.01962226,0.036065117,-0.021845764,0.004352641,-0.025550378,0.02394379,0.054328807,0.025295978,-0.086030334,0.030488562,0.06898302,-0.051067006,0.016746575,0.06549219,0.013098035,0.014732028,0.0721379,0.050419126,0.04646133,0.046218306,0.03848605,-0.02241436,0.00044750012,-0.10103977,-0.018195495,-0.02549232,0.09202547,0.04197396,0.044810887,0.0713761,-0.021593513,0.02335403,0.11936843,0.029182805,0.05390036,0.09223379,0.012070931,-0.080926105,0.001083098,0.060652122,0.027369201,-0.0050053643,0.011524187,0.0074358745,0.011495073,0.021516062,-0.07848944,-0.105594166,0.009704643,0.049231023,0.008755584,-0.017239003,-0.029167486,0.07697086,0.013387044,-0.036342174,0.015457652,-3.1764174e-08,0.024823647,-0.008570208,0.016717989,-0.021157267,0.06455179,0.026772412,-0.0016006206,-0.035926647,-0.0067765024,-0.050140526,-0.03913117,0.179609,0.039485507,-0.030623613,0.041287646,-0.043026395,-0.010033009,-0.008225935,-0.02860587,-0.027809344,-0.04736334,0.04935401,-0.0944151,0.015262923,-0.02216161,-0.055324193,0.0471787,0.019240184,0.03451048,0.0050794533,0.0022337118,-0.025101298,0.031135565,-0.031928375,-0.078412704,0.056581467,0.0302226,-0.09383645,-0.027571151,0.027951114,-0.079618365,-0.063720316,0.0027494743,-0.026626637,-0.011391944,-0.0007757472,0.051344715,-0.007046851,-0.01578884,0.01698349,-0.0038971426,-0.008800819,0.006405793,-0.04819332,-0.07558561,-0.024236469,-0.038275175,-0.09169677,-0.031493247,-0.0701162,0.038068112,0.064932495,0.14004648,0.019124892 +1.21.3.7,"A flavoprotein (FAD). The cofactor is covalently bound. Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta9-THCA with lower efficiency. Whereas the product was originally called Delta1-tetrahydrocannabinolate, the recommended name according to systematic peripheral numbering is Delta9-tetrahydrocannabinolate.",384,1.0,-0.028971946,-0.018650116,-0.16837695,-0.04410958,0.04161287,0.04504167,0.0048117233,0.07430984,0.015767321,-0.068116724,0.029751558,0.025694244,-0.10130348,-0.00059833005,-0.064199865,-0.025100326,-0.000957716,-0.0044959495,-0.069181435,-0.04123291,0.016294148,0.11417379,0.033049986,-0.013028797,0.017139317,-0.020284157,-0.06124453,-0.03800531,0.07697339,-0.06241074,0.040861513,0.118317164,-0.011490792,0.029319711,-0.043135133,-0.045575034,-0.024271335,0.025208762,0.027604962,0.013792279,0.10026597,0.048668146,0.025651602,0.039931186,-0.027319778,0.015480141,-0.0030692297,0.043912,-0.00993713,0.036467787,0.034588102,-0.06354682,-0.07379866,0.06980951,-0.010934429,0.021837264,-0.026572382,0.036678687,-0.0009568123,0.07513203,0.003386876,0.039230235,0.0077757854,0.0027759569,0.10413724,-0.06327664,-0.062342707,-0.08461249,0.02560475,-0.046381038,0.01683609,-0.029033082,-0.044462584,0.02388405,-0.0077431463,0.0803061,-0.036390822,0.013736346,0.026453935,-0.023064472,0.053051427,0.026631692,0.05070389,0.05979676,0.018549304,-0.07244419,-0.05818388,0.056727886,0.02274019,0.0013871414,0.057378277,0.0540375,0.017953236,-0.013151343,-0.14615001,0.053236555,0.09188854,-0.022598037,-0.029448118,-0.03399969,-0.0032720487,0.029250136,-0.019774849,-0.057833258,-0.08689994,-0.029847583,-0.0037530644,-0.013211993,0.0086342245,0.016019426,-0.025323292,-0.050026163,0.06102533,-0.051939692,-0.065706864,-0.056679416,-0.047755964,-0.018789858,0.06392882,-0.087874755,-0.07300596,0.052500825,0.053894408,0.070770524,0.01695043,0.0060769264,-0.10681563,3.4334846e-33,0.032401808,0.034241296,-0.027724113,0.022006748,0.039324123,-0.044675667,-0.009771267,-0.020911805,-0.026651565,-0.01702991,-0.016712978,-0.00029857576,-0.047161255,-0.036063883,0.036335077,-0.015108914,-0.082560696,-0.054940302,0.06311474,-0.07117721,-0.026947794,0.14751184,-0.10322983,0.06599986,-0.005105447,-0.025376413,-0.02770302,0.016799748,0.008115022,0.018166874,-0.021281626,0.004174319,-0.075678796,-0.011734505,-0.022594497,0.028345333,0.01722823,-0.036043957,-0.112493664,-0.0026100501,0.058135506,-0.0034802333,-0.0135610225,0.023756001,0.026930371,-0.013776084,-0.10219134,0.041257102,0.015232197,0.0684661,-0.01079242,-0.03374036,0.10352895,0.05178013,-0.097328715,-0.003763871,-0.037567317,0.050399687,0.014208145,0.017850256,-0.026015952,0.061457343,-0.0547945,0.13580772,-0.05411204,-0.0074013574,-0.026048142,-0.10097895,0.059722107,0.08349671,-0.03544521,-0.020351442,0.068583064,0.0065890616,0.06209994,-0.043466344,-0.018196087,-0.0032947876,-0.025046516,-0.0075327638,-0.02356831,-0.045808602,-0.028036505,0.0024883272,-0.061934397,-0.026510313,-0.017872157,-0.03478059,-0.028933523,-0.03478101,-0.005770696,-0.0005226478,0.04200581,0.035689965,0.057897404,-3.314966e-33,0.05777598,-0.10755754,0.111579105,-0.010906517,0.029800903,0.02721688,0.021973448,-0.06452036,0.048275594,-0.06287179,0.042176504,-0.05519055,0.028810605,0.006610245,0.03167689,-0.032116357,-0.045603015,0.08633184,-0.03489869,0.059513308,-0.09262794,0.02448709,-0.018412739,0.07473639,-0.016719867,0.025531998,0.04196845,0.016320998,0.010735162,0.031099461,-0.010945723,0.031939406,-0.0843497,-0.035740804,-0.16745119,-0.034908254,0.015024973,-0.0023537076,-0.07371861,-0.025402285,0.0025309485,0.06282587,0.0031745983,0.01867879,0.047871668,0.024005108,0.0062561934,-0.016646927,0.053929772,0.019985802,0.027343433,0.024629267,-0.037489165,0.07530226,0.09746568,0.022272099,0.08847259,-0.012352179,-0.007255193,-0.038613506,0.024658527,-0.034539655,-0.0046517327,-0.03553541,0.08567557,0.020995263,0.06465651,0.10768682,0.07897154,0.032938834,0.11900188,0.057806704,0.062188447,0.09249958,0.0036416822,-0.02162328,0.046623517,0.007412603,-0.005030329,-0.027207328,0.00591829,-0.014272864,-0.01676719,0.046283733,0.027304566,-0.060621265,-0.010317361,0.09167403,0.056474168,0.04657541,-0.037725694,0.007825261,-0.023690863,0.022181258,0.03389614,-3.918931e-08,0.005753058,-0.05426902,-0.052086707,-0.016342694,-0.0010671505,0.047891937,-0.027841417,-0.06595522,0.027103407,-0.052857693,-0.007676337,0.08408269,-0.039579924,0.055396955,0.045331787,-0.013947349,0.003247192,0.036623906,-0.0027640385,0.012674193,-0.16829215,0.011295426,-0.0031184088,0.002136766,-0.105682485,-0.0072430093,-0.041851528,0.055681657,0.0694506,0.009583244,-0.014964921,0.026991457,0.048156545,-0.006118699,-0.07894879,-0.018678652,0.066270195,-0.033640124,0.014734832,0.03459668,-0.035199698,-0.028371502,-0.04567307,-0.004799367,-0.03096805,-0.06636772,0.080351695,0.03947044,-0.036989875,-0.0049691536,-0.02744102,0.024460448,-0.013768962,-0.084103815,-0.057122767,-0.05545274,-0.047726765,0.0066478923,-0.035356153,-0.092355356,0.035961896,0.036755927,0.1545587,-0.012843052 +1.21.3.8,Binds FAD covalently. Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also convert cannabinerolate to cannabidiolate with lower efficiency.,384,1.0,0.0011858945,-0.0055454113,-0.101134256,-0.040032685,0.011074838,0.0788738,-0.058764067,0.033845734,0.0530195,0.012650202,-0.009941151,0.029855806,-0.08004855,0.007450093,-0.033783875,0.014071325,-0.08037303,0.026840776,-0.06800893,0.02057244,0.019244663,0.114697434,-0.0016759937,-0.002651365,0.016055167,0.0143803535,-0.014505729,-0.042484973,0.069252275,-0.05599913,-0.0069063623,0.06353727,-0.056970157,0.038669482,-0.06123931,0.037791517,0.020522138,0.0053668004,0.064184725,0.007786953,0.109503545,0.013263846,-0.022855684,0.031385154,-0.017967483,0.027419072,-0.0020476535,0.031448867,-0.0086902175,-0.035934065,0.06039137,-0.07089389,-0.031939752,0.023265554,-0.0136843575,0.04206454,-0.0066111377,0.07706329,0.037477054,0.083251216,0.024775429,0.034400024,-0.009455126,0.02112689,0.0813345,-0.056167208,-0.057098802,-0.022345647,0.01591772,-0.052579198,0.0549161,-0.0877059,-0.0017537028,-0.059601434,0.026929865,0.0748457,-0.07199434,0.029181784,0.0010925657,-0.08013046,0.016994871,0.06901485,0.05072517,0.098558284,0.02960771,-0.040502116,-0.016381096,0.023524405,-0.030285953,0.013139944,0.034953404,-0.0030078653,-0.01727016,-0.044020433,-0.089862734,0.043752376,0.12254415,-0.03724679,-0.041798986,-0.057897083,0.0010972184,0.10286236,-0.096501,-0.07432589,-0.048733477,-0.029304855,-0.024762588,-0.056867767,-0.044409223,0.016388163,-0.0051093157,-0.020999193,0.07152006,-0.029737502,-0.05745155,-0.037854888,-0.06470262,-0.02186773,0.03400269,-0.10198173,-0.100138046,0.02788425,-0.006015783,0.09600752,0.039238766,-0.058832828,-0.09036043,3.223382e-33,0.028881224,0.0074166916,-0.043429732,0.013222771,0.021781549,-0.046714637,-0.04662915,-0.015578058,-0.022103157,-0.001762918,0.027410284,-0.03312258,-0.026095094,-0.020693345,0.0010645152,-0.024308898,-0.077481456,-0.04572788,0.084109195,-0.06757191,-0.08937513,0.09268279,-0.10697603,0.050959054,-0.0214506,-0.009745547,0.0013370004,0.017700471,0.07778821,-0.024997845,-0.0011605961,0.0045530926,-0.07690152,0.033321112,-0.0525771,0.019759038,0.037151605,-0.015208965,-0.121132374,0.013207177,0.068778,0.008819275,0.013105397,0.010548173,0.01668087,0.0005367669,-0.08159707,0.045033395,0.039249964,0.07471524,0.00850341,-0.018792318,0.110926665,0.025992682,-0.08852919,-0.016671201,-0.087577805,-0.006165263,0.005048998,0.037121203,-0.013787523,0.008453135,-0.035703577,0.1155161,-0.010459068,0.04334648,-0.05241288,-0.106491186,0.069057204,0.09959836,-0.06420339,-0.008818391,0.049003955,0.013038582,-0.009233229,0.006450588,-0.011050097,-0.024025658,-0.011763362,0.037475504,0.006252969,-0.060346816,-0.053650063,-0.030374428,-0.004609422,-0.059213966,0.008882136,-0.0685518,-0.016922522,-0.0075377314,-0.0068149026,-0.04807549,0.012261679,0.03519819,0.09201992,-4.0934288e-33,0.10256008,-0.108373486,0.13297014,-0.009950469,-0.011881143,0.0748982,-0.031684775,-0.07670269,0.061338767,-0.025278652,0.064516224,-0.018047392,0.05482943,0.053496275,-0.01597544,-0.015671665,-0.04891347,0.057656676,-0.039257683,0.07000909,-0.09503685,0.048305415,-0.0017002082,0.07651637,0.00803683,0.027664306,-0.04006001,0.03709979,-0.02165133,0.047298267,0.0770743,0.04116874,-0.13664758,-0.036508184,-0.16831866,0.0010455154,0.021043317,0.014921699,-0.05459619,-0.035365466,0.03004923,0.03617188,0.000607039,0.05851426,0.06619552,0.017618269,-0.0010088995,0.047229968,0.03371597,0.022535495,0.04569175,0.039144445,-0.018941939,0.028208653,0.09266159,-0.03414573,0.05055682,-0.054164555,0.017500523,-0.08187722,0.024878733,-0.016611457,-0.012526875,-0.05910835,0.014884571,-0.018168095,0.025681203,0.07011466,0.05721149,0.08302095,0.08839214,0.033993453,0.10678842,0.09018088,0.014216978,-0.0023307954,0.061889436,-0.07120506,-0.0009558169,-0.01796702,0.029927319,0.03099469,-0.049623027,0.018907238,0.030654108,0.05838213,0.016039554,0.09382927,0.027270565,0.019188087,-0.049719255,0.04169062,0.004026489,0.00016526441,0.028915629,-2.9283655e-08,0.018533347,-0.04337181,0.0007393931,-0.06561972,-0.039288316,0.05982315,-0.014462107,0.019218931,0.0033260544,-0.05471927,-0.0397219,0.046820108,-0.057284757,0.026387373,0.06662941,-0.009747624,-0.0028554555,0.03110725,-0.015751695,-0.045877185,-0.13485989,-0.018646142,-0.03624512,0.039598793,-0.05499406,-0.040056884,0.018672178,-0.004335348,-0.0125247715,0.051306948,0.0706736,-0.018121766,0.0087219,-0.011702369,-0.025233693,-0.0036755682,0.055254348,0.013656577,0.006836669,-0.003797223,-0.01630568,-0.04272644,-0.07189686,-0.01705049,-0.06762112,-0.043195896,0.053620882,0.059998866,-0.04398912,0.043576263,-0.014200408,-0.01703498,0.07266272,-0.107197225,-0.076517954,-0.04911309,-0.02729442,-0.0021594227,-0.012001221,-0.027324935,-0.045250464,0.029519565,0.13454683,-0.019762175 +2.1.1.260,"This enzyme, which occurs in both prokaryotes and eukaryotes, recognizes specific pseudouridine residues (Psi) in small subunits of ribosomal RNA based on the local RNA structure. It recognizes Psi914 in 16S rRNA from the archaeon Methanocaldococcus jannaschii, Psi1191 in yeast 18S rRNA, and Psi1248 in human 18S rRNA.",384,1.0,-0.04601544,-0.0015952426,-0.13182648,-0.11379836,0.0692793,0.05318499,-0.07770775,0.015960168,-0.011259492,-0.017268606,0.011419816,-0.005855122,-0.0869434,0.120025754,-0.11192108,-0.012386648,-0.097633794,-0.015065798,0.046676844,0.0064376504,0.068527535,0.14449303,0.02357238,0.03209403,0.015203925,0.009430438,0.080037765,-0.0072760214,0.021378912,0.018164817,0.032949638,-0.048435256,0.11612779,-0.0059274957,0.11351345,0.056546338,-0.045613553,-0.028034035,0.09660671,0.054057553,0.06486432,0.049647454,-0.003891242,-0.029874783,0.025045374,0.05549555,0.0066436655,0.103490055,0.060373273,0.01398485,-0.031609856,-0.06383917,-0.036370054,0.036793765,0.031642597,0.081647225,-0.013244103,-0.07628254,-0.023909874,0.008793639,0.0003475199,-0.09006665,0.015883198,-0.027497552,0.050580904,-0.005495166,0.046188485,-0.049252648,0.048187677,-0.055056818,0.0288027,0.020494923,-0.028131276,0.10684499,-0.02741072,-0.008960571,0.008682844,-0.04985928,-0.034937307,-0.008388977,-0.07878634,-0.090303026,0.06655658,0.020653263,-0.01250303,0.046492513,0.0014711873,0.039666783,0.05157185,-0.0075272643,0.0033560686,-0.03185829,-0.013820806,-0.048953816,-0.0524102,-0.030462293,0.047912214,0.09091658,0.0073942356,-0.04214622,0.06425788,0.03657598,-0.061050143,-0.066802785,0.0129926205,0.05579658,0.028861098,0.0028724582,-0.044588353,0.003288188,0.058549106,0.036023688,0.039479535,-0.055620838,0.00999333,-0.053468026,0.051745538,-0.059368435,-0.068115756,-0.012136698,-0.033664435,-0.0380703,0.066358104,0.071370475,-0.041706774,0.01589737,-0.14721656,5.443456e-33,0.008825872,0.0357008,0.016098168,-0.039599225,-0.021143703,0.04268845,-0.04373997,-0.007654735,-0.041202057,-0.09031226,-0.07582871,-0.0409338,0.02337587,-0.04178984,-0.09327055,-0.026684888,0.0025649427,-0.010594709,-0.014547184,-0.032409154,0.0035691753,0.08887688,0.028078176,-0.01671886,0.043120462,0.01360524,0.011887435,-0.052742813,0.09375386,-0.011821264,0.008898522,-0.022757046,-0.14501522,0.08183591,0.05112436,0.024686176,0.004214294,-0.04390017,-0.015856491,0.08208309,0.056621544,-0.019668292,0.0213288,-0.0146857165,0.028951492,-0.041415006,0.0066271927,0.05038216,-0.043419786,0.022578461,-0.0004476811,-0.016948475,0.037460674,-0.05552683,-0.057102915,-0.077913344,-0.014406148,-0.034090966,0.062249683,0.055918854,-0.00023350313,-0.04103524,-0.034407135,0.07489368,-0.0071494547,-0.043569256,-0.07218714,-0.13497584,0.0734718,0.08954039,-0.019754244,0.015163862,0.07623131,0.037011,-0.02877163,-0.0438344,-0.05718158,0.04223218,-0.024342036,0.05647825,-0.023361025,-0.013029435,-0.007332216,0.032453224,-0.041287098,-0.021630531,0.07544069,-0.10420087,-0.053892523,0.0007441068,0.04278165,-0.061845805,-0.04129823,0.045753505,0.0009785667,-6.03978e-33,0.09439921,-0.07638944,0.04139878,-0.050173614,-0.10071507,0.008104733,-0.0005058124,-0.051548187,0.005572165,-0.12707642,0.081147775,-0.04257579,0.056805693,-0.029272474,0.01571047,0.03159358,0.023321072,0.07015716,0.008676085,0.030203797,-0.00045387872,0.05455109,-0.06350987,0.042712174,0.016168458,-0.014036223,0.04092413,0.03430641,0.011599174,-0.009497923,-0.016758481,0.043984357,-0.036083635,-0.049659446,-0.055798233,0.031361252,-0.03058045,0.012454527,0.087046266,0.010232117,0.023202159,0.08138131,-0.09334296,0.039802875,-0.06410052,0.039169766,-0.0034319884,0.031990923,-0.060943965,-0.078220606,0.02117356,-0.05485739,0.062006395,0.02668672,0.03793775,-0.016109487,-0.0736941,0.08356997,0.02712704,0.01845845,0.010724357,-0.06646789,-0.0060894187,0.011739347,0.017999882,0.018399533,-0.05340635,0.010546519,-0.014311726,-0.009497559,0.005257563,0.020773962,0.027315404,0.052217454,-0.037210945,-0.07227562,-0.08763814,-0.016445864,0.015675249,-0.012051861,-0.034091495,-0.052303012,0.03250016,0.01187371,0.04770135,-0.0338959,0.07061796,0.03407036,-0.074068464,0.016375136,0.01664084,0.008083299,-0.005274576,0.017734192,0.05750908,-3.92479e-08,0.046267115,-0.00020642522,0.023262374,-0.07422583,0.010897028,0.021367872,0.014059037,0.019261977,0.0028785062,-0.004095508,0.035617195,-0.02221135,0.009345467,-0.07985059,0.040162314,0.035424437,-0.12731771,0.05888859,-0.009043057,0.012870025,0.020965539,0.042196833,-0.087168105,0.005314845,-0.080314375,0.0343001,0.017459836,0.05393572,0.009148609,-0.08918128,-0.009940781,-0.03144258,0.05431855,-0.08000255,-0.03838704,0.030943703,0.070438914,0.009268827,0.027591199,-0.011975101,0.05347071,-0.081599325,-0.10890327,-0.029766163,-0.042802278,-0.030095454,0.019511197,0.034192815,-0.026687328,-0.010245453,0.1067496,0.07876255,0.05703253,0.004653009,-0.03960944,0.0010881751,-0.057043638,-0.06447179,-0.07539565,0.049479824,0.055567827,0.05774201,0.06455228,-0.06403269 +2.1.1.261,The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi. ,384,1.0,0.0070381025,0.0274249,-0.09969603,0.021248927,0.055502236,0.039395977,-0.04048819,0.04808028,0.056069795,0.0050843307,0.03545191,-0.06834354,-0.06187658,-0.060930494,-0.05097829,0.02867385,-0.049962416,0.07641612,-0.016651453,-0.059013296,0.058053393,0.014638587,0.044220272,0.03541119,0.055801835,-0.033628426,0.03968746,-0.052530024,-0.05264113,-0.15295759,-0.03240067,-0.07500691,0.04964512,-0.033323936,-0.024194049,0.04550159,-0.041231185,-0.01434716,0.03519118,0.03926723,-0.0064806705,-0.020724481,-0.012481658,0.032876678,-0.109181255,-0.01596848,-0.046149604,0.02822958,0.004887519,-0.025231615,-0.010079041,0.012375647,-0.047213078,0.0059686434,0.039451174,0.0063202735,-0.011832682,0.040340647,-0.028894871,0.02615278,0.12438259,0.013762495,-0.062456243,-0.02114371,-0.08270468,-0.03519811,0.050719887,-0.051728535,-0.061117847,-0.03026452,-0.05590187,-0.07426241,-0.05724571,-0.0017854348,0.07288392,0.090374924,-0.0010097418,-0.005837319,-0.096518286,0.011643555,0.07045701,0.08262289,0.07909837,0.0076228953,-0.015979635,0.021125045,0.012594199,0.06520883,0.05943023,0.054199588,0.091509335,-0.062259912,0.009087961,0.010091469,-0.030603,0.08321047,0.043294534,0.052431196,0.033253115,-0.049826406,0.05468195,0.018513512,-0.01804616,-0.033598457,-0.014495014,-0.0062307497,-0.015053565,0.01626052,0.03484104,-0.057883352,0.048595037,-0.033766143,0.04831414,-0.0075669475,-0.045866627,0.072785966,0.029396176,-0.06310425,-0.0950702,0.050042555,0.0016935572,0.021582002,-0.014535109,0.028265318,-0.011396577,-0.063244164,-0.07372167,9.485834e-34,0.09135408,0.053787775,-0.10797847,-0.016843835,0.044725943,0.03335353,-0.06699684,-0.038954534,-0.051975675,0.0067515695,-0.084994584,-0.050327122,-0.01969302,-0.010346911,-0.022992484,0.038557675,7.078782e-05,-0.017636659,0.055003002,-0.015554181,-0.020233046,-0.014314018,-0.13521816,-0.030687455,-0.03927885,0.11032431,-0.0023781355,0.024652882,-0.009827127,-0.03374757,-0.014867806,-0.102614984,-0.07091588,0.088272646,0.040993508,-0.03119485,0.059066158,-0.016509518,0.05853112,-0.064689174,0.00443045,0.10337648,-0.009028997,0.0023375808,0.070288144,-0.009371216,0.0050581414,0.078962564,0.11299462,0.0863148,-0.0067172055,-0.016622638,0.11518814,0.071273364,-0.049705047,0.05156318,-0.040744644,0.015888892,0.023314476,0.059791494,-0.014418067,0.03726336,0.014699702,0.042717557,0.025752837,-0.0042265304,-0.008890918,-0.07024437,0.022236433,0.0608013,-0.03565815,-0.059022635,0.043942716,-0.016683962,-0.05377152,-0.030426867,-0.03587719,-0.0043170736,-0.028854527,0.021319613,-0.023136484,-0.0126465475,-0.04369026,-0.0073963227,-0.03593875,0.018405508,-0.050982617,-0.034066457,-0.028800216,0.07334024,-0.03419288,-0.012584806,-0.05602063,0.05952907,0.039235104,-2.0985555e-33,0.17274563,-0.08848343,0.022222549,-0.064347275,-0.0048820386,0.042053558,0.009130451,0.04958142,-0.040796738,0.02838954,0.02995066,-0.0070391195,0.015770907,-0.0027122528,-0.03197381,-0.07404747,0.04709901,0.11262317,0.0017817423,0.02615759,-0.08818026,0.078298084,-0.089321174,0.04568955,0.03268672,0.024327844,0.019046122,0.027644003,-0.08194498,0.027160816,0.009248825,-0.011891015,-0.05172671,-0.019878754,-0.041878276,0.10852352,0.023612503,0.035996016,-0.020754267,0.016640618,0.014107091,0.009425915,0.008628711,-0.009006338,0.085275546,0.06470903,-0.032179065,0.06384014,-0.00041405347,-0.09697757,0.049609832,0.05040177,0.046990044,0.013309658,-0.012836642,0.018754883,0.041816637,-0.037800197,-0.010442986,0.029134026,-0.065651014,-0.0014856681,0.03568309,-0.017533738,-0.029254364,0.029365208,-0.044188295,0.0043075792,0.08612453,0.014796819,0.07189804,0.020835081,-0.017286126,0.08853474,-0.05758482,-0.038390603,0.005319251,-0.07359918,0.047925834,0.005437607,0.0505738,0.023626916,0.037450872,-0.09124718,-0.025783801,-0.08828846,0.021576457,0.07452077,-0.054932244,0.045153912,0.07305208,-0.045946103,-0.030242397,0.090954386,0.049635652,-2.2970445e-08,0.041947864,-0.027568273,0.029390527,-0.04593875,-0.020986581,-0.027226368,0.07696981,0.015731651,-0.020878593,-0.026192704,-0.061071225,0.026326887,-0.029852666,0.10244802,0.13207667,-0.003679843,0.013462296,0.060382016,-0.025161173,0.026525024,-0.02045081,-0.04066494,-0.049180772,-0.038244754,0.037913065,-0.037183817,0.009573903,-0.00714875,0.08265176,0.07095088,0.04777156,0.0024309785,0.005892692,-0.027539933,-0.012905428,-0.021847693,-0.0658165,-0.07443671,0.01773353,-0.078773044,-0.040764887,-0.037485417,-0.033003263,-0.010299544,-0.12277659,-0.025265709,-0.032844923,-0.0021714699,0.04444418,-0.017094186,0.06888246,-0.061237823,-0.00071576674,-0.100013524,-0.12038293,-0.033755466,0.052746397,-0.032627206,-0.0040011685,-0.086223416,0.013667927,-0.013019035,0.11433215,-0.022448836 +2.1.1.262,Two isoforms differing in their specificity were isolated from the green alga Botryococcus braunii BOT22. TMT-1 gave more of the dimethylated form whereas TMT2 gave more of the monomethylated form.,384,1.0,-0.04939901,-0.030361844,-0.0088810595,-0.02848978,-0.06423743,0.016153814,-0.09476645,0.0033937201,0.0068343375,0.024837116,0.16412227,-0.1513625,-0.024889078,-0.0058311615,0.017116625,-0.008342273,-0.058143746,-0.060877766,0.018954903,-0.018820994,0.089991964,0.104465716,-0.021351133,-0.011234292,0.032138117,-0.00061440375,-0.11205263,0.08269558,0.101501,-0.09614296,-0.015037994,0.06741069,0.012737436,-0.029138898,0.0830123,-0.03973282,-0.0008384398,-0.0066089365,0.14526463,0.032203358,0.018135162,-0.010464907,0.024068363,0.054197986,0.0007299048,0.036867194,0.007616978,0.10564044,-0.03609712,-0.0028150287,-0.0013354539,-0.036055982,-0.022174448,0.011292721,-0.021535449,-0.056864984,0.090814374,0.022999562,0.023620175,-0.0110927,0.021049151,-0.022364043,0.056547713,0.039912246,-0.053807702,-0.0023930813,-0.041695595,-0.12281656,0.025206346,-0.050707407,-0.029276397,-0.018758046,0.01569338,0.027087996,0.02409886,0.107854314,0.050690107,-0.11420571,-0.104235515,0.108406775,-0.00012275485,0.04706832,0.043062083,0.03075158,-0.062227037,-0.08531666,0.009377527,0.063021705,-0.10798229,0.016406221,0.034621585,0.034418747,0.041829016,-0.035384532,-0.05183953,0.01652962,-0.0015042337,0.046703298,0.09817717,-0.03313263,0.0049311635,-0.09171924,-0.11467108,-0.06789719,0.014570938,-0.002025119,0.065114416,-0.0017729905,0.041213453,-0.00047433187,0.0062637166,0.05760759,-0.059734322,-0.006773428,-0.028481608,-0.002715231,0.05701801,-0.00036705835,0.04355844,-0.043537974,-0.019532489,-0.042026304,0.007690673,-0.0101187555,-0.018285872,-0.07381414,-0.035790477,3.3903964e-33,0.03445687,0.000529488,-0.06711673,-0.023203425,0.07678418,0.007555767,-0.013187054,-0.0701353,-0.01972029,-0.020403184,-0.08535019,0.0026860868,-0.009640333,0.027712395,-0.12134507,0.047301583,-0.04030416,0.0348906,-0.012587039,-0.06127167,0.031047339,0.10373722,0.028208572,-0.02236776,0.107752986,0.08025315,0.05645764,-0.066405825,0.0023615365,-0.050631806,0.015366849,-0.068316765,-0.0985049,0.01818385,0.09604572,-0.04184163,-0.0234204,-0.0055002673,-0.0033710212,-0.033068825,0.01595978,0.122486845,0.05365138,-0.095994756,0.0998558,0.022917496,-0.09214546,0.035600763,0.022293637,-0.0494583,-0.029269272,0.0405018,0.062193673,-0.0053595905,0.0060480633,-0.013623995,0.014272844,0.009687855,-0.03894679,0.034104414,0.0060070343,0.080679424,0.025462966,-0.020608762,-0.0040771514,-0.005765272,-0.048753988,-0.018384235,0.016778395,0.006696599,-0.0042922045,0.021976111,-0.008145569,-0.062408056,0.012753898,-0.042588286,0.019450705,-0.054362908,-0.050553143,0.015217935,-0.048531774,0.03781993,0.043013263,-0.08621172,-0.094410606,0.009794748,-0.052177645,0.013994427,0.05303618,0.05214964,0.013247163,0.007550601,-0.13798603,-0.016350307,0.013638757,-5.371551e-33,0.016703855,0.017411152,0.08473525,-0.08464363,-0.046798993,0.01935494,-0.028537877,0.05171206,0.033152822,0.030967606,0.091138825,0.067531325,-0.049836997,-0.10129756,-0.02067465,-0.10782141,0.02010798,0.091665834,-0.006951346,0.022613758,-0.09529296,0.05820266,-0.04010723,-0.015706263,0.046849236,0.054343645,-0.050972514,0.07661262,0.033099625,0.0059422064,0.0118640745,0.010803832,0.037930604,-0.027145734,0.009318847,-0.0015370237,-0.053503457,0.014693324,-0.0010838009,0.062903225,0.0150491735,-0.023051757,0.009746853,-0.020033319,0.020633183,0.08848499,-0.032998428,-0.03898146,-0.00016171696,0.029885955,0.043728024,0.032213707,-0.010725111,0.010303013,0.06917008,0.011273209,0.01891228,0.01056999,0.0115523385,-0.0036711164,0.05393558,-0.07981395,-0.0017449481,-0.044952277,-0.009665556,0.0033035583,-0.01800463,0.004548833,0.03592724,-0.014751819,0.04830807,0.107577816,-0.066190556,-0.08513853,-0.018988246,-0.0010904822,-0.08399585,-0.09571396,-0.036079183,-0.013313998,0.00938436,0.0017860761,-0.0039025524,0.052527517,0.050779853,0.015602771,0.049293328,0.0027997808,-0.07001131,0.05151291,-0.024960333,0.026745994,-0.039305486,0.05099568,0.0011821244,-3.47612e-08,0.020873068,0.007901326,0.012724093,0.00709383,-0.13037819,0.047423586,-0.058848873,0.027286632,0.09228352,0.030735122,0.015670337,-0.0071794367,0.003062708,-0.0047971355,0.044019055,-0.081484415,-0.13725159,-0.06124865,0.042546082,0.024476575,-0.044194434,-0.05524891,-0.08487168,-0.0031527742,-0.02052209,0.0070392285,-0.0108655235,0.03985956,0.04075347,-0.022705916,0.048650026,0.017357102,-0.009864716,-0.032685082,-0.0057473173,-0.0395307,-0.085272305,-0.015044525,-0.01018454,0.0033094354,0.04381045,0.005667635,-0.084314555,0.010903846,-0.0117395315,-0.035409756,0.020815555,0.019597301,0.0032744752,-0.0070729316,0.019266877,-0.0006866108,-0.010267033,0.0013063407,-0.07090002,0.003554402,0.010792729,-0.021931563,-0.025943669,0.051177654,0.029894587,-0.10758083,0.10201486,-0.032894053 +2.1.1.263,Isolated from the green alga Botryococcus braunii BOT22. Shows a very weak activity with squalene.,384,0.99999994,-0.04255035,-0.070207365,-0.025942337,-0.0060143094,-0.043608915,0.041026536,-0.08495579,0.019702395,-0.014102036,0.05787366,0.099280514,-0.13904865,-0.038558736,0.070805326,-0.027582662,0.04882033,0.016995454,-0.04998655,0.026439086,0.02309328,0.12701845,0.08835126,0.010894906,-0.025280574,-0.005559605,0.0039689695,-0.074077055,0.0011688618,0.015549671,-0.08463642,0.052028444,0.031833734,-0.008229886,-0.033257253,0.088167,0.028683448,0.0052308147,-0.053629503,0.18514596,0.097510636,0.002620534,0.020071473,0.037360165,0.039565686,0.021445485,0.035513964,-0.0552611,0.1292703,0.053805407,-0.058235917,-0.02706935,-0.068577476,0.024156934,0.018683424,-0.013099762,-0.08340847,0.10160636,-0.030595334,0.04428318,-0.009786221,0.09371206,-0.030788334,0.10052604,0.023974994,-0.1268223,-0.013772415,-0.07484761,-0.04569838,0.047896184,-0.0073988046,-0.029369013,-0.05686157,-0.03031314,0.029247498,0.074490495,0.042778566,0.028608834,-0.14458352,-0.04229429,0.06992016,-0.022360884,-0.014342646,0.023824884,0.032102227,0.009198712,-0.077718265,0.10112948,0.0024917806,-0.06663815,0.03063917,-0.029992279,0.02944821,0.041708395,-0.051526535,-0.055611894,0.030154467,-0.0024953275,0.014875311,-0.023664618,0.0064837635,0.0025778792,-0.116342016,-0.003126447,-0.09804041,-0.013352222,0.021559596,0.044529837,-0.005911745,0.031028818,-0.022988053,-0.052020553,0.06658401,-0.07004838,1.7783774e-05,-0.02299471,0.0063126264,0.11636174,-0.023652293,0.01506676,-0.012508981,-0.006847906,-0.0023498263,0.019918129,-0.0010739027,0.017337495,-0.026469715,-0.027012357,9.420497e-34,-0.009537843,-0.047506332,-0.025676392,-0.08284817,0.05485028,0.019515378,-0.043473423,-0.058648616,-0.020671481,-0.048027992,-0.032766297,0.013393863,-0.0068723247,0.037725337,-0.07884275,0.004105322,0.037060793,0.01045886,0.038123697,-0.060085934,0.06316521,0.005467563,-0.01960936,0.005614754,0.10466739,0.0522886,0.072292686,-0.089016184,0.0077589815,-0.040098414,0.051134795,-0.040168583,-0.08690819,-0.018229883,0.012483162,-0.03830671,-0.03295235,-0.05377957,-0.072905585,-0.051219016,-0.02750491,0.08119757,0.028512089,-0.03179905,0.07031727,0.03635947,-0.049726196,0.050188497,0.074193574,-0.025501523,-0.026559167,0.0007095961,0.08625339,0.03976869,-0.020405242,-0.011134108,-0.03405455,-0.026372433,0.0010528524,0.029918259,0.05823631,0.11860658,1.0051606e-05,0.0072866483,-0.020314427,-0.06406729,-0.013348073,0.014264894,-0.01769922,-0.009807822,-0.060368314,0.019950103,0.016493846,-0.08572352,0.02327402,-0.040718343,-0.008715499,-0.026516734,-0.065831035,-0.0015305269,-0.049979985,-0.040638484,0.08290989,-0.029817136,-0.09115073,0.053961087,-0.06352495,0.022630446,0.061425414,0.061605304,0.028282808,-0.030376818,-0.1302419,0.0493752,-0.008570776,-1.7662247e-33,0.051857825,0.019021409,0.12023356,-0.019866426,0.01974617,0.076509446,-0.029073615,0.06502776,0.0042795725,-0.021407403,0.0010571273,0.028497986,0.0402298,-0.06194986,0.045532547,0.028828243,0.06628477,7.976097e-06,0.0049560326,0.031010583,-0.10164129,0.061855476,-0.014114734,-0.09412531,0.056109414,0.030753735,-0.018175531,0.04889457,0.0046447446,-0.01800408,0.04620238,0.0763028,-0.039911877,-0.0814737,-0.009385003,0.016290432,-0.051733322,-0.013751249,-0.0064764246,0.027443036,0.047730025,-0.020626081,-0.07174352,0.054990437,0.045650747,0.09215245,-0.008295238,-5.4398537e-05,-0.024175886,0.07748338,0.033665918,0.026430635,0.0068274247,0.018563958,0.0476838,-0.0122938445,-0.011313083,0.02528146,0.010332518,0.018425204,0.04953317,-0.050065007,-0.05190595,-0.020207912,-0.0010591439,0.034812298,-0.045438033,0.026321549,0.04365815,-0.044219323,0.068169095,0.10502202,-0.083765134,-0.01774882,-0.017633474,0.05438333,-0.049414355,-0.12411171,-0.020263538,0.034906235,0.036920562,0.0036827284,0.0601457,-0.004411466,0.056260876,-0.015595973,0.014269329,-0.015584461,-0.0673567,0.025176017,-0.07147905,0.0050197146,-0.09814228,0.0060361414,-0.0047159162,-2.3535382e-08,0.0057557933,0.027319796,0.05551975,-0.014142195,-0.02522036,-0.010883958,0.009165454,0.048858084,0.048132736,0.043120585,-0.0016671078,-0.038349565,0.040005066,-0.010897757,0.0783042,-0.054760274,-0.08312474,-0.02406149,0.041633636,0.009598031,-0.028273545,-0.06732104,-0.08335806,0.029362753,-0.08215672,-0.024716565,0.07598444,0.016245008,0.004083142,-0.017411573,0.060909588,0.045404386,0.006974091,-0.029624537,-0.03525583,-0.013425923,-0.107638806,0.0054981764,0.034693133,0.029331185,0.0010009528,-0.0062147146,-0.05597226,0.0007168415,-0.055069223,-0.02219123,0.015324948,-0.07439629,0.045031764,-0.019687254,0.046151575,-0.03173564,0.002004403,0.07740987,-0.046405755,-0.009056798,0.028940313,-0.076852046,-0.055742964,0.023925936,-0.020446839,-0.13955519,0.08501738,0.032232706 +2.1.1.264,"The enzyme specifically methylates guanine2069 at position N7 in 23S rRNA. In gamma-proteobacteria the enzyme also catalyses EC 2.1.1.173, 23S rRNA (guanine2445-N2)-methyltransferase, while in beta-proteobacteria the activities are carried out by separate proteins [1]. The enzyme from the gamma-proteobacterium Escherichia coli has RNA unwinding activity as well [1].",384,0.99999994,-0.05359517,-0.072648644,-0.14511384,-0.030447397,0.021472933,0.07035483,-0.0120029375,0.044908162,-0.011224721,-0.009405653,0.047035143,-6.335152e-05,-0.030323671,0.04588267,-0.0048271585,0.008627636,-0.09584934,-0.05235523,0.041911356,-0.028978594,0.054010063,0.029857103,-0.034658704,-0.043770522,-0.009004251,0.03866456,0.07024212,-0.0726385,0.0133472495,-0.050668027,0.011690748,-0.064878926,-0.0083204005,0.06411436,0.040051404,0.07488259,-0.07388384,-0.057514295,0.02943401,0.023036197,0.072546795,0.07797636,-0.0041776453,-0.034963686,0.031005772,0.010361276,0.047206324,-0.023517253,-0.0043803584,-0.04348367,-0.022713175,-0.088067025,-0.005242519,0.02459723,0.05474478,0.044781025,-0.0010019025,-0.118628256,-0.015336758,0.03618965,0.07635619,-0.04882901,0.0272444,-0.09353567,0.008457693,-0.035712495,0.015086668,-0.00389147,-0.019678712,-0.07319995,-0.07154463,0.014165694,-0.08594969,0.06,-0.10563623,0.037723042,0.03720985,-0.052547,0.016792685,-0.037189476,-0.0023730956,-0.018077554,0.03675137,-0.014100074,0.088574246,0.02917081,0.0696029,0.10341927,0.076772876,0.072021134,0.0353217,0.057323586,0.04766897,-0.026418708,-0.096595116,-0.00033892546,-0.028755832,0.002190668,0.031494267,-0.023858655,0.0136860395,0.094148576,-0.022848545,-0.029412549,-0.059729036,0.0333252,0.03802692,0.09035429,-0.02155024,0.027320806,0.00478003,0.0777166,0.0014105747,0.03285371,-0.014956727,0.06134355,0.031892456,-0.0012979659,-0.03732452,0.012899305,-0.045437176,0.01130836,0.011713721,-0.02033303,-0.07496388,0.028990198,-0.11568176,5.7510716e-33,-0.007083932,-0.0061657033,-0.032928456,-0.0045542195,0.07911408,0.1038011,-0.083821684,0.025744246,0.037298772,-0.037924692,-0.104972675,-0.09126225,-0.0011623945,-0.0008544332,-0.026263326,0.047284555,-0.007603076,0.015667764,0.001945498,-0.04565705,4.0893334e-05,0.0035971215,-0.016606625,-0.06941162,0.024486741,0.019345686,0.010267169,-0.039258033,0.0489526,-0.031823587,-0.061794303,-0.10539298,-0.06351312,0.09294839,0.1363869,0.018405778,-0.0064399843,0.02924248,0.018989231,0.08488187,0.034036893,0.012758245,-0.03264218,-0.0013110527,-0.00042537707,-0.0570082,0.0037411312,0.08559619,0.03442288,0.026199672,0.03965553,-0.025834128,0.02415222,-0.021170279,-0.041108422,-0.008542581,-0.025677327,-0.021199305,0.021802044,0.0059311464,0.03243822,-0.01826005,0.0009468404,-0.00447506,0.025685692,0.02177357,-0.105125956,-0.068554156,0.02648346,0.07400968,-0.013677862,-0.021725552,0.16299064,-0.045891434,0.0050776727,-0.02484488,-0.11389197,-0.05395904,0.05204175,0.06348347,-0.053913478,0.071659975,0.0053957393,-0.044218022,-0.02773691,0.032127354,-0.0042308485,-0.0710634,0.055180572,0.057362244,0.07673449,-0.028566828,-0.07003411,-0.0041389116,0.033411857,-4.4982216e-33,0.058168624,-0.063688256,0.019115597,-0.104067445,-0.018785171,-0.0054816394,-0.00017900918,-0.06757207,-0.04789135,-0.06933755,0.09847487,0.016163895,0.0778759,-0.026524976,0.063307025,-0.028990326,0.013172436,0.10926019,-0.014165942,-0.06388206,0.03235777,0.01888792,-0.028457481,0.029931394,0.023543166,0.031312328,0.025601683,0.043011993,0.10406989,0.0054369285,-0.07615724,0.007964524,-0.021522794,-0.05198452,-0.014239725,0.03166352,0.010398625,0.016680239,0.026258092,-0.012806179,-0.037237197,0.0637298,-0.026215933,0.10904755,-0.030267067,0.1158948,0.017060313,-0.043689653,-0.015642688,-0.03965025,0.049874276,-0.07860041,-0.035347052,0.023772953,0.0254227,-0.009017997,-0.06530634,-0.0062480983,-0.032708656,-0.017752588,0.0143245645,-0.05321993,-0.04257474,-0.022581298,0.035261434,0.046559565,0.0037203783,0.07445219,0.038662944,-0.045926325,0.02667423,-0.020029072,-0.03480027,0.014451471,-0.03324026,-0.0677045,-0.058982845,0.0013676066,0.021457773,-0.09272871,0.021313742,0.00538278,-0.08503553,-0.06400716,0.003328114,-0.046628304,0.051711563,0.11607944,-0.012219849,0.04264692,-0.07736812,0.022805767,-0.027673332,0.08892924,0.056063622,-3.8687805e-08,-0.03577729,-0.07282685,0.019430986,-0.03360912,0.030911773,0.05662262,-0.04603284,0.050139897,0.105154924,-0.013718178,-0.00032132858,0.014904236,-0.014907152,0.020494998,0.0006082681,0.07331665,-0.03530629,0.028497782,0.024166007,0.00605296,-0.045777716,0.050268665,-0.10662196,0.029298715,-0.065300964,-0.03557483,-0.010844598,0.10818944,-0.036976486,-0.07473605,0.022741094,0.02447628,0.06618304,-0.019814944,-0.051963188,0.021940207,0.10993322,-0.016696054,0.037248474,-0.012072795,0.029736599,-0.025908928,-0.09216715,0.026773037,-0.056401018,-0.01017278,-0.054570854,0.033418335,-0.026063746,0.026568254,0.059289806,0.00971717,0.026064832,-0.0063440204,-0.046077423,-0.00440296,-0.018511632,-0.090334915,-0.07570224,0.06530335,0.044327974,-0.05506189,0.13965651,-0.061383996 +2.1.1.265,The enzyme is involved in the detoxification of tellurite. It can also methylate selenite and selenium dioxide.,384,1.0,-0.019915776,-0.0085779345,0.022125723,0.025077745,0.09458856,-0.0076438338,-0.007230829,0.06615443,0.004742848,-0.0577628,0.017336769,-0.038323056,-0.028718935,-0.02355406,-0.01744484,0.060137972,-0.02537407,0.029899979,0.024019064,0.0026378047,0.11739907,0.07599098,0.007823615,0.050050654,0.05315586,0.023169743,0.024613557,-0.040048353,0.016203534,-0.041471183,-0.040390063,-0.0048083444,0.053261627,0.0063849664,-0.06220378,0.08452737,-0.045880716,-0.0020220713,-0.014242411,-0.014820396,0.01761582,0.035931025,-0.069306076,-0.027478375,-0.03499225,-0.005579314,0.02706134,-0.04128687,-0.06728241,0.024520421,-0.042734344,-0.04524505,-0.029674994,-0.016284721,-0.0010030301,-0.009511098,-0.030932216,0.02366029,-0.090915695,0.060363155,0.0565842,-0.05133629,-0.026859269,-0.01869592,0.1209166,-0.027370598,0.027577916,-0.038562033,-2.5913764e-06,-0.123834446,-0.020957442,-0.06902953,0.04592295,-0.055400018,-0.059380326,0.051535342,0.0039047978,0.011594581,0.027243828,0.021517927,0.01386232,0.01273563,-0.01892219,0.06602251,0.024723744,-4.6434558e-05,-0.0453264,0.03231352,-0.02376929,-0.034064632,0.0033631907,0.0044083963,-0.047799,0.015523061,0.012485176,0.044684753,0.016807416,0.04395997,0.0033684466,-0.011897142,-0.02704413,0.10769687,-0.072625846,-0.08027966,-0.067876644,-0.03410772,0.052349217,0.003735227,0.038367387,-0.022830702,0.057791397,0.040412903,0.09949226,0.09292232,-0.004695422,0.10699625,0.07733494,-0.019425917,-0.013641323,-0.004548168,0.018141873,-0.076187335,0.004409063,0.04619244,-0.043150023,-0.016348863,-0.019023214,-5.6884875e-35,0.05898193,0.03820555,0.023144577,0.08787932,-0.03708024,0.03612924,-0.028793726,0.029565534,0.019932736,-0.009781893,-0.066091284,-0.08653501,0.029075617,0.03980855,-0.07865483,-0.05412574,0.01407922,0.016683016,0.11861396,-0.13225876,0.088386096,0.062124655,-0.07827823,-0.011899643,0.007994632,0.022626542,-0.048768673,-0.03723884,0.06187226,-0.031022748,0.07527768,-0.021099996,-0.07928049,0.025681557,0.010834255,0.07599108,-0.10652134,0.033495,-0.05211544,0.014554386,0.025662582,0.025278294,-0.023613,-0.007140257,0.034444675,-0.13308793,-0.09530667,0.08046037,0.057663657,0.06480434,-0.004105954,-0.014642291,0.056473047,-0.041901693,-0.04683099,-0.037550315,0.022954542,-0.049078,-0.021325806,0.098151855,-0.023933649,0.041952893,-0.04254904,0.031095214,0.00071613654,-0.0019383915,-0.10404441,-0.00687965,-0.018719537,0.10521833,-0.08425451,0.070091225,0.016375208,0.014386479,-0.08669821,-0.058509026,-0.11107905,-0.0057209274,0.03811665,-0.012685117,0.006680176,-0.07054718,-0.025929093,-0.01177409,-0.06493726,0.021356445,-0.017101245,-0.002539667,-0.024994826,0.015942218,0.05746107,-0.046457745,-0.07180047,-0.023699282,-0.014994026,-5.349879e-34,0.0341565,-0.07872878,-0.008796312,-0.04895138,0.04781938,0.0045653665,0.0055528977,0.076315045,0.02079583,-0.021575311,0.01816921,0.0015676403,0.07982974,-0.04739355,-0.025595149,0.10500601,-0.0074691423,0.045370955,-0.041177414,-0.04913587,-0.037941083,0.10100608,-0.0014247445,0.009291797,0.03985568,0.058613002,-0.029247422,0.009797799,0.057539538,0.08085374,-0.0123457005,-0.024798365,-0.02102045,-0.013498334,-0.015804484,0.043400254,-0.083222285,-0.028990272,-0.0026220318,-0.0039087483,-0.04517812,0.023438571,0.052819453,0.09024838,0.045090288,0.05568518,-0.09722972,-0.050821085,0.04335822,0.036129355,0.090249516,0.003952918,-0.035454806,-0.014138231,0.063379504,0.024654849,-0.064220265,-0.041240174,-0.14825831,-0.040771287,-0.0028503668,-0.008174592,-0.029616283,-0.0135867875,0.044439286,-0.019383866,-0.10176407,0.076774836,0.028095612,-0.007315767,0.04146488,-0.004548051,-0.029709062,-0.023355694,-0.071754016,-0.07535984,-0.07789149,0.03915834,0.016081646,0.011082847,0.025972381,0.017795067,0.036534324,-0.011800025,0.025277369,-0.0018894168,3.8230773e-05,0.1158057,0.013786975,0.010982752,-0.09027687,-0.042862255,-0.050140418,0.062933005,0.07517534,-2.4733561e-08,0.06322024,-0.11173577,0.0125854835,0.0049440456,-0.08373395,0.005101636,0.028350865,0.10257731,-0.02036537,-0.040060837,-0.06358755,0.08512886,-0.017347358,0.009684369,0.06796874,-0.018098488,0.0064816447,0.036741354,-0.045096744,-0.0868588,-0.054882802,-0.06889638,-0.04146341,0.07640702,0.07863777,-0.016505258,-0.024667412,0.0550421,0.047456466,-0.022510603,0.019401593,-0.067762144,0.05903919,0.00054211303,-0.07146966,0.08415544,0.04574947,-0.030161407,-0.025511747,0.106262565,-0.0021779218,-0.035841703,-0.050065786,0.0279414,-0.044968013,-0.039317295,0.028559,0.012964509,0.019433687,-0.004378797,0.027305927,-0.00024461758,-0.032465275,0.019597966,-0.0601306,0.010594752,0.016092952,0.045687273,0.012593347,-0.022751013,0.020620558,0.077950515,0.20124401,-0.042344388 +2.3.1.204,"In the bacterium Bacillus subtilis it has been shown that the enzyme catalyses the +amidotransfer of the octanoyl moiety from [glycine cleavage system H]-N6-octanoyl-L-lysine (i.e. octanoyl-GcvH) to the E2 subunit (dihydrolipoamide acetyltransferase) of pyruvate dehydrogenase.",384,1.0,-0.08663741,-0.04722295,-0.10223187,-0.0648021,0.04499399,-0.012485805,-0.12822315,0.011898728,0.012978317,-0.00312479,0.025229279,-0.066677764,-0.045803096,0.006861247,-0.030812012,0.041063108,-0.10246802,-0.005591394,0.040006574,-0.0029950812,0.05561124,0.07521238,-0.04130447,-0.05783029,0.06326421,0.0034738507,0.084251225,-0.010956291,-0.03690824,-0.0464204,0.0280218,-0.07278425,0.04249991,-0.09342306,0.10706739,0.122975454,-0.015364358,-0.009047558,0.13282095,0.017411353,-0.027526736,0.007894071,-0.025883397,-0.022437774,-0.037338942,0.05392975,0.08942422,0.07270355,0.016721822,-0.025918517,-0.012782564,-0.004191644,-0.07043824,0.018421685,0.009096712,-0.055554997,-0.08403451,0.028526297,0.011887947,0.011009853,-0.008449559,0.022326816,0.03880016,-0.018722372,-0.015848126,-0.063550375,0.10218872,-0.09525167,0.014564573,-0.014910449,-0.095079444,-0.03593901,0.027741607,-0.035236094,0.022154212,-0.00052186206,-0.09253555,-0.01553267,0.055505496,-0.035769504,0.07056299,-0.041167215,0.01748082,0.071272664,0.019627566,-0.0162766,0.0038406043,0.012656133,0.045720156,0.027055033,-0.010068353,-0.047026485,-0.009570653,-0.08230307,-0.01717309,-0.019503675,0.019253772,0.024103153,0.017123334,-0.040768456,-0.048052035,0.07329839,-0.07022076,-0.01879306,-0.03204906,-0.0062297015,0.014176469,0.17203559,0.0546118,0.021814633,0.032345247,0.07293362,0.041511502,-0.037072595,-0.03833891,0.06457843,0.0014228333,-0.07161702,-0.079342514,-0.045997776,0.021619124,0.024861177,0.0793649,0.07365273,-0.053412244,0.012091472,-0.075890034,5.6752015e-33,0.024273194,0.03479784,0.021628108,-0.06893675,0.009707701,-0.055091962,-0.11266384,0.019444095,-0.010882728,-0.029684495,-0.08736968,-0.07434428,0.06285148,0.02626026,-0.005146675,-0.013958594,0.025716938,-0.012672159,0.0024315407,-0.018188251,0.052585416,0.029001763,0.050548494,0.044177964,0.017415477,0.065023534,0.07077419,0.06542455,0.06846822,-0.02718559,0.009507124,-0.13229935,-0.05115808,-0.018099973,0.05841357,-0.013595664,-0.063977145,-0.047483172,0.01924691,0.06194561,-0.03602516,0.023831245,0.010836772,-0.02794527,-0.01673864,0.06659011,0.04608331,0.08436176,-0.0037627646,-0.01736544,0.046692584,-0.03252873,0.09622399,-0.060363796,-0.06569035,0.014851846,0.00489696,0.011744464,0.018714275,0.035098277,-0.0089401575,0.020873366,0.05528194,0.013252491,-0.015555845,-0.033329725,-0.08758658,-0.03133975,0.029671993,0.06579381,-0.06370719,-0.010968953,0.12598872,0.0052055544,0.01049714,0.022586767,-0.0745546,-0.0015996075,0.020115849,-0.035706766,0.03312268,0.026767109,0.03948357,-0.082993634,0.018693458,0.010867028,-0.054948896,-0.06869063,0.0162299,0.0942502,-0.029548483,-0.08449598,-0.018718109,0.0041344557,0.02188414,-5.5968934e-33,0.117581576,-0.07919152,0.022487722,-0.09278525,-0.06751668,0.06652371,0.019242387,-0.014170859,-0.013689183,-0.027073292,0.011103786,0.045533292,0.046096273,-0.009029049,0.06219974,-0.002049369,0.052263077,0.07063919,-0.007213519,-0.032792483,0.014019594,0.04900986,-0.018660707,-0.08628269,0.04086122,0.054304365,-0.016730897,0.12615685,0.11200072,0.009847523,-0.016970094,0.018825626,-0.040739335,-0.02280932,-0.04015712,0.0960302,-0.04117057,-0.013419064,0.017612254,0.02810306,0.025814734,0.0024699983,-0.06081956,0.037596177,0.03905257,0.011074628,-0.029974926,0.027208267,-0.05929175,-0.07600149,0.0020749005,0.012699709,-0.032451075,-0.041364532,0.04804153,0.077887066,-0.0073253936,-0.013020056,0.0363005,-0.055696256,-0.041546978,-0.09738643,0.051582094,0.0110486075,0.018222567,0.055856034,0.03876141,0.017868057,0.046749838,-0.03146734,0.058072656,-0.04365169,-0.008866482,0.085456125,0.014584119,0.004874631,-0.06408979,-0.056669373,0.014440728,-0.05203638,-0.015905768,-0.08558323,-0.013209666,-0.030282218,0.016289312,-0.071794875,0.04171144,0.11398553,-0.010964837,-0.027389519,0.011695578,-0.035035014,0.042677235,0.06945891,0.06376079,-4.1349395e-08,0.040718447,-0.052697722,0.07788416,-0.0035988009,0.00525794,0.035787374,0.013518202,0.032408677,0.0017387389,-0.07506447,0.0070184045,0.004450378,-0.0036592379,-0.057959605,0.008333468,0.049513783,-0.03072887,0.026286775,-0.024475478,0.009997769,-0.08073718,-0.025233746,-0.10955285,0.021626506,-0.027454428,-0.069267124,0.013911727,0.021726029,-0.041309204,-0.06435933,0.004992779,0.04782172,0.0023916818,-0.060481668,-0.04762897,-0.043608658,-0.038132858,0.02657518,0.044780992,0.014003741,0.029751357,-0.0037792304,-0.07220465,0.07855435,0.016225435,0.09319468,-0.055762168,0.030196048,-0.07725966,0.041554984,0.07197529,0.02372888,-0.0017556949,-0.007541371,-0.097037844,-0.029900393,-0.07569586,-0.06849061,-0.028310612,-0.0024627447,0.005661242,0.03381002,0.13950905,-0.08579814 +2.3.1.205,"The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.",384,1.0,-0.037470575,0.014683606,-0.18340756,-0.0040114857,-0.018705592,0.022717947,-0.094807416,0.03150449,0.049254294,-0.007110733,0.05125133,-0.18119761,-0.088942185,-0.028498791,-0.10009523,-0.0045108646,-0.052973695,0.03180773,-0.016779076,-0.058626298,-0.0021014307,0.01755035,0.07073417,0.024111707,-0.02126411,-0.03414725,-0.060877502,0.032171603,-0.026718846,-0.113441326,-0.027594993,0.00036758246,0.061355952,0.00915154,0.018921468,0.05017844,-0.096606575,-0.05341672,0.103264205,0.018071074,-0.059998237,0.0008519874,-0.022554498,0.020860262,-0.03859039,0.020534761,-0.022870146,0.0994159,0.05039398,0.06997368,0.00882458,0.01959579,-0.05429397,0.015867166,0.04939653,0.0019167971,0.018469224,0.007235197,-0.06573592,0.10149719,0.115593866,0.05410826,-0.10371995,0.024910534,-0.11967295,-0.028690038,0.028254803,-0.066545464,0.0073017147,-0.06288845,-0.0052348203,-0.08589543,-0.0056135603,-0.008105094,0.040076945,0.13816692,0.02812225,-0.0044298526,-0.07605967,-0.031994704,0.10335358,0.03657134,0.07525745,0.04803258,0.014405931,-0.04712417,-0.02494268,0.032475237,0.035694182,0.051475827,0.120511,0.003991292,0.025470207,-0.027062632,-0.03633221,0.08306571,0.01058111,0.043942787,-0.010445709,-0.046486128,0.0029273063,-0.043726005,0.049240895,-0.0430953,0.013003957,-0.00681799,-0.016923448,0.04836578,0.06510825,-0.06511169,-0.031556148,0.040373024,0.046469975,-0.040010344,-0.06404385,0.114924416,0.08269461,-0.057968777,-0.044170655,0.06017189,-0.0063434574,-0.0036781721,0.025929192,0.053026542,0.016989965,-0.09369567,-0.06590487,1.0289076e-33,0.04395547,0.06965707,-0.064471506,-0.006913882,-0.009862249,-0.015905537,0.0293982,-0.064785026,-0.10749606,-0.030049073,-0.0634068,-0.029818164,0.0046098,0.05300924,-0.051751368,0.049889956,-0.0044064866,-0.06269162,0.018476874,-0.03883645,-0.009118017,0.0015857562,-0.080390185,-0.041173723,0.016608028,0.10105464,-0.007062359,0.07123908,0.010824096,-0.015891204,-0.04104561,-0.07717856,-0.034373645,0.03772883,0.073332556,0.052917246,-0.034333475,-0.040146563,-0.0062630815,0.035173308,0.012708308,0.069588505,-0.023938641,-0.02722307,0.039695237,-0.0015572117,-0.03337675,0.11134582,0.06455003,0.06676814,0.043846577,-0.014702477,0.10252881,0.061585587,-0.07544315,0.037190486,0.0055094506,-0.0032366216,0.017119637,0.057346486,-0.041345526,0.051884826,0.01761366,0.063400485,0.007139217,-0.047912747,-0.04925935,-0.0894421,0.034270793,0.07577514,-0.015773658,-0.072758034,0.036186483,-0.025414653,-0.0037529094,0.025458042,-0.08639664,-0.06413219,-0.047937546,-0.019317979,0.019542888,-0.052099716,0.019480405,-0.03801326,-0.05916517,-0.017950598,-0.06268843,-0.0135712335,-0.02510627,0.03928172,-0.010717657,-0.00976912,-0.027538374,-0.0005861644,0.057393305,-1.8338063e-33,0.06159205,-0.042535696,-0.007527812,-0.03468737,-0.03453242,0.050504565,-0.05498443,-0.041349526,-0.03366674,0.04903911,0.073987186,-0.04722917,0.045017336,-0.0041368357,-0.028178178,-0.015259824,0.0907083,0.09366707,0.009983627,0.049093593,-0.044995785,0.03006975,-0.03190669,0.025053699,-0.007963986,0.037059437,0.0071967053,-0.015974903,-0.029935665,0.036309104,-0.053002935,0.010069908,-0.015214149,-0.04106817,0.042650536,0.010374697,0.03570269,0.007334755,0.03368214,0.014075205,0.020621216,0.07778643,0.054488264,0.031156346,0.07522126,0.043898314,0.0015644034,0.017503075,-0.035933282,-0.027322711,0.04548018,-0.00032440264,0.027344067,0.061901323,0.0017927083,0.0024230257,0.05864833,-0.063329145,-0.032401614,0.0070516923,-0.054727294,-0.07802303,-0.008596448,-0.07130353,0.029293641,0.07353704,-0.021990294,0.054218125,0.08360335,0.009450185,0.045514837,0.031589456,-0.024479201,0.03627675,-0.15704696,-0.0062857796,0.0074604303,-0.03921771,0.03844238,0.0031940944,0.049156252,0.0060491436,0.080509506,-0.050438337,-0.008105686,-0.10465824,0.030489957,0.065407865,-0.03541479,0.037525512,0.017224263,0.0017401502,-0.05421403,0.03122152,0.054432444,-2.7403901e-08,0.050991744,-0.04374026,-0.014643273,0.008470113,0.021576116,0.007821527,0.0330209,-0.016382314,-0.036837652,0.019739117,-0.044199914,0.06982667,-0.025356365,0.07003056,0.08174367,0.03217082,0.0056183534,0.06385552,0.0026223203,0.047605995,-0.0027777227,0.023513993,-0.056438986,-0.019875323,-0.026249954,-0.036161005,-0.0144550195,-0.030536842,0.07048003,0.045282982,0.033047356,0.022103786,-0.044110905,-0.058329243,-0.06701877,-0.042608272,-0.013508338,-0.08284159,-0.046092458,-0.0056001353,0.0067909863,0.06434237,-0.05553763,0.011507491,-0.07231844,-0.072905146,0.004107352,0.0066012926,0.051745284,0.0065646,0.050028596,-0.031901106,-0.008045774,-0.038480893,-0.09684167,-0.03546599,0.0081760045,0.011168676,-0.013800881,-0.07658342,-0.024198834,-0.01775597,0.16667743,-0.029606543 +2.3.1.206,"A polyketide synthase catalysing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalysed by EC 4.4.1.26, olivetolic acid cyclase.",384,1.0,0.008562483,0.07412253,-0.0871887,-0.01868909,0.03828315,0.09007737,-0.06501116,0.00017654082,0.031169042,0.016383473,-0.03139404,-0.008307772,-0.019100206,-0.033287853,-0.111813426,0.025418287,-0.06069389,0.08584052,-0.046511803,-0.046802863,0.028133232,0.034622006,0.024253728,0.060014892,0.0010717608,0.00087309035,-0.01684957,-0.062776275,-0.0120008625,-0.05945402,0.024528518,0.036790416,0.06447579,0.019828664,0.021014927,0.030201022,-0.051437177,-0.017650373,0.07012177,0.0031648497,0.10600625,-0.0125292465,-0.038036868,-0.0054483125,-0.058220804,0.029847817,0.008317724,-0.0451726,-0.0015701272,-0.1173316,0.018871108,-0.038798373,-0.013879583,-0.028933203,0.034668565,-0.032692377,-0.0697398,0.0728289,0.06914988,0.0635375,0.074456096,0.020122653,0.021291597,0.04294263,0.07033205,-0.037860572,-0.029666405,-0.05333514,-0.0035214508,-0.079662174,-0.03603516,-0.033864614,-0.089534916,-0.0029391581,-0.00094613625,0.06639486,-0.035175703,0.036061257,-0.06488234,-0.06973128,0.06544964,0.037821103,-0.010709582,0.019230861,0.061859548,0.021577368,-0.0011934774,0.02596977,0.047919903,0.011066596,0.055087887,-0.007973673,-0.04606646,-0.011219349,-0.039183468,0.0066079157,0.06770488,-0.029554259,0.05620365,0.0036380624,0.01508011,0.098343536,-0.040235758,-0.10974086,-0.03594124,0.018545207,0.033139713,-0.03712191,0.03281233,0.010125579,-0.052646704,-0.08209595,0.027933404,0.022736851,-0.037166245,0.07164604,-0.006822254,0.023052968,0.02135089,-0.056611884,-0.0039564865,-0.03952107,-0.02051701,0.06596987,-0.041521594,0.012851478,-0.13086475,2.676879e-33,0.00589595,0.0803738,0.0448658,0.012677889,0.023594825,-0.050540287,-0.004227802,-0.024746887,-0.011082549,-0.06947416,-0.04264056,-0.05501897,0.007135867,-0.0014201815,-0.0069237743,-0.06051085,-0.068969905,-0.00081314665,0.042478815,-0.062325563,-0.108457915,-0.031394914,-0.12676977,0.03579641,-0.044773914,0.04422811,0.039275315,-0.07799177,0.092922665,-0.020851847,-0.10102487,0.019916767,-0.10885035,0.038969845,-0.005454347,0.0033545862,0.073208496,-0.046175912,0.012384535,0.06799737,-0.06072813,-0.021318832,0.05580516,-0.07505057,0.011622639,0.029305546,-0.11924024,0.06211441,0.066152185,0.080828,0.0033172464,-0.011417299,0.098701574,-0.007338034,-0.05590686,0.034273393,-0.047913104,-0.0120251225,-0.024070349,0.06726677,0.0012673648,0.06573882,-0.07178003,0.010689931,-0.061108895,0.006978859,-0.06702193,-0.062534265,0.041796755,0.029214557,-0.071492575,0.022484224,0.050285377,0.007221984,0.049177036,0.020180756,-0.086706966,0.019472089,0.003619787,0.026356155,-0.003806756,-0.029941717,-0.062911205,-0.0055148546,0.008699321,-0.01251913,0.02734399,0.0059200414,-0.04964048,0.058655616,0.0018745207,-0.07829356,0.011392644,0.06465036,0.027326163,-2.8993948e-33,0.109128214,-0.036001828,0.07123941,-0.06556504,0.008987425,0.008004882,-0.045974158,-0.07908022,0.015157735,-0.026016189,0.03839224,-0.06820695,0.14393446,0.022937596,-0.012884421,-0.045713346,0.010145456,0.08300398,-0.064421505,0.060705315,-0.02380915,0.030007584,-0.032033857,0.02731207,0.02738369,0.03681306,0.00643769,0.11667534,0.012549509,0.053587835,-0.0070793116,0.062325325,-0.07710593,0.023758257,-0.050753642,0.06990143,0.028854635,-0.03388083,-0.004811263,0.02916791,-0.035366796,0.04446821,0.013336764,0.06405022,0.0971173,0.08643202,0.039431535,0.09842337,0.04182367,-0.0071910936,0.06176378,0.08815881,-0.022783356,0.06798967,0.0434582,0.030819165,0.040443327,-0.026461443,-0.08550204,-0.10147205,-0.0467097,0.00020014853,0.030098597,-0.03333869,-0.032167755,-0.014343107,-0.005351344,0.045060534,0.0072177774,0.024425864,0.106460534,-0.019270439,0.013304656,0.0772704,-0.028552476,-0.020206835,-0.002218967,-0.09726633,-0.03042344,-0.035079554,-0.029265458,0.020036068,0.014360385,-0.054265875,0.067731224,-0.04996535,0.0049480167,0.058039095,0.0041207676,0.021250498,-0.046400905,0.025498016,-0.033208795,0.13381849,0.032901093,-3.2900626e-08,-0.004626718,-0.0540934,-0.05257471,-0.033772938,0.034205846,0.052196838,0.03731137,-0.017190376,-0.00090351154,-0.14602476,-0.031364564,0.009572817,0.012306952,0.063340895,0.0827047,0.012962896,0.03082261,0.022802694,0.0186844,0.009030636,-0.08244749,-0.033948842,-0.055833925,-0.027322343,-0.06612565,-0.058227643,0.052017905,0.02112081,0.0049962876,0.04417625,0.049854252,0.044394772,0.0028790296,-0.018278215,0.0026015907,0.02292988,-0.003486967,-0.0027667033,0.06850395,-0.052896213,-0.030667562,-0.032434803,-0.10438619,0.0050922753,-0.031965986,-0.066404566,-0.0050175255,-0.0051906114,-0.024999369,-0.018269751,-0.0066901026,-0.00012904042,0.06671817,-0.06460043,0.01254714,0.0086298315,0.00012669805,-0.0013127668,-0.023037938,-0.061534733,-0.060743786,0.019319,0.2161266,-0.0032490792 +2.3.1.207,"This enzyme, which has been characterized from the bacterium Pseudomonas aeruginosa PAO1, catalyses the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via beta-oxidation, with malonyl-[acp], forming 3-oxodecanoyl-[acp], an intermediate of the fatty acid elongation cycle. The enzyme provides a shunt for beta-oxidation degradation intermediates into de novo fatty acid biosynthesis.",384,0.99999994,-0.1232525,-0.029323908,-0.07829794,0.061331872,0.060290918,0.031097105,-0.11297529,0.028685741,0.02957712,-0.066307224,0.040992536,-0.05539668,-0.109314375,-0.010144741,-0.081482455,0.048493255,-0.06009311,0.009253252,0.051993024,0.011624899,0.056141507,0.03910649,-0.067104295,0.032210328,0.06717575,0.04849396,0.07829208,-0.01879321,0.016541885,-0.042721603,0.027101105,-0.06692953,0.10171879,-0.041095752,0.061095595,0.044597346,0.028437661,-0.058690745,0.062308345,0.012155559,0.042884205,-0.0642266,-0.046183765,-0.028718827,0.034801632,-0.03153763,-0.007687989,0.07747904,0.056882035,-0.066526145,-0.072428904,-0.05498168,-0.061388653,0.052275855,-0.0326762,-0.024186261,-0.006606513,-0.054582063,-0.037633106,0.015004278,0.04295391,0.014529592,-0.00030557674,0.06923988,-0.03449247,-0.06010513,0.016799493,-0.034769148,0.038791105,-0.013477456,-0.07737674,-0.025448477,0.03433809,0.019053085,-0.0076203425,-0.0028420507,0.005713941,-0.10187121,0.051402878,-0.0041216807,0.04951959,0.009656947,0.020504735,0.06575843,0.013262712,-0.063295886,0.006241733,-0.030689465,0.023955742,0.035363574,0.015631638,0.016156066,-0.009521224,-0.0625489,-0.045881435,0.08019523,0.037433267,-0.0077539114,0.010576956,-0.01936741,-0.043918088,0.061635446,-0.040022198,-0.10876388,-0.027810471,0.015794016,-0.020539604,0.095084146,0.06390834,0.023720562,0.008663847,-0.05324941,0.0011987023,-0.011037475,0.00059040764,0.08501584,-0.018982764,-0.06619771,-0.07662469,0.06201545,-0.071798064,-0.05907136,0.008288178,0.018236423,-0.0045586987,-0.011447813,-0.054687127,1.1580167e-33,0.06012408,0.0121794725,-0.05326122,-0.054907873,0.030899225,-0.06294142,-0.08962254,-0.004598854,-0.054848287,0.0027145126,0.008546386,-0.07245951,-0.014174915,0.039392024,0.06875237,-0.028638873,-0.019537656,0.03740163,0.12344976,0.015186623,0.0006322186,0.0074689346,0.009293408,-0.036544535,0.06126878,0.061902355,0.015013906,0.025088051,0.00037928973,0.012923857,0.033210948,0.0058670216,-0.08785096,-0.020856528,0.094975516,-0.039015394,-0.06484622,-0.020653272,-0.019957036,0.12653507,0.08175474,0.02900178,-0.013040574,-0.024419473,0.04425663,0.016494961,-0.02343411,0.10488765,0.09063505,0.013913414,0.0652716,-0.008863983,0.041061558,0.031863637,-0.026557451,0.005813546,-0.082829684,-0.0051407185,0.03529202,-0.09604118,0.020329475,0.031230744,-0.039719827,0.019722044,-0.048283283,-0.08279417,-0.055335604,-0.012401644,0.008400594,0.03260711,-0.022772308,-0.035240848,0.050018344,0.005023011,0.016996877,-0.044483423,-0.026157347,0.04776779,0.046001382,-0.0044983407,0.00908405,-0.0043668454,0.046930294,-0.06942213,-0.016868815,0.050022002,-0.003286271,0.05821785,0.024030665,0.0029355069,0.0015790999,-0.09663456,-0.02474536,0.030552061,-0.012934767,-3.1645546e-33,0.10180074,-0.1405178,0.045070596,-0.11904781,-0.051514063,0.02376886,-0.035499737,0.028769618,0.026413657,-0.0038861732,0.052127518,0.05548211,0.06524259,-0.020213638,0.06919846,0.065104015,0.03782839,-0.01697238,-0.052695833,-0.056497335,0.070590176,0.028554037,-0.028871274,0.0259487,0.05244136,0.010981975,-0.045525614,0.099706374,0.06363199,0.11200004,-0.027884064,0.018347982,-0.012240097,-0.022506105,-0.021235097,0.059971146,-0.05515662,0.039844934,0.03215511,0.065709904,0.0649601,-0.016979832,-0.05488358,0.006487015,0.056775432,-0.020665616,-0.009265179,-0.027234057,0.038072653,-0.14374079,0.032640096,0.010335866,-0.03405285,0.06376528,0.013404458,0.06766132,-0.0743474,0.026883004,0.0004145662,-0.11722361,-0.037203785,-0.10282122,0.018650359,-0.061134454,0.061894532,0.10923059,0.022889541,-0.03414795,-0.018355701,-0.0051365034,0.03141983,0.023063459,-0.0030064657,0.059315413,-0.011611862,-0.044046648,-0.05761627,-0.05223003,-0.067982875,0.013930079,-0.04250092,-0.040916104,-0.02360218,-0.05232736,-0.075949095,-0.05367967,0.05232408,0.10695391,-0.054979566,0.03932588,0.0016097142,0.0058393725,-0.008874202,0.037430234,0.027481718,-3.6810555e-08,0.010264469,-0.058084887,0.11549351,0.035479877,-0.006463724,0.04312808,0.029269561,-0.02865716,0.026381157,-0.07204576,-0.04830922,0.101193026,0.032330863,0.028550845,0.05602306,-0.058687557,-0.054987576,0.021043262,-0.012965862,-0.08423225,-0.08664161,-0.02722904,0.0063468586,0.013607096,-0.032340363,-0.015441639,0.05465649,-0.04196407,-0.024495505,-0.013205464,-0.035586886,0.091385424,0.017016372,-0.02735272,0.0006255954,-0.02587875,0.009792717,-0.06448618,-0.05009302,0.023283591,0.060184326,0.021006534,-0.0881351,0.01591681,0.047295146,0.017928876,0.035950948,0.031117292,-0.015199827,-0.055751648,0.07624432,0.004799026,-0.09582209,0.009692759,-0.04538866,-0.04584702,-0.031047955,-0.04521127,-0.10083191,-0.0060290867,0.00084731187,-0.004720399,0.16143188,-0.059634414 +2.3.1.208,"The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177, biphenyl synthase) [1].",384,0.99999994,-0.069971204,-0.06781507,0.0019255227,-0.041087173,0.067928605,0.003866781,-0.08874968,-0.013999637,0.053322915,-0.06269172,-0.035864294,-0.08614218,-0.027294394,0.014813714,-0.046583086,0.030300295,-0.09656211,0.060884196,0.011485061,-0.010013759,0.038994122,0.022369066,-0.018790854,0.026941195,0.036521595,-0.059298623,0.09361047,-0.04401707,0.007899808,-0.082561016,0.04996829,0.0030943046,-0.030264078,-0.022967085,0.053281754,0.056288578,-0.03215997,-0.036042318,0.01674837,0.037645407,0.10827057,-0.09488325,-0.06066967,-0.018941602,-0.061112337,-0.035856545,-0.047402956,-0.03377378,0.030167336,-0.055236783,-0.07935237,-0.035713974,-0.029955205,0.06145528,-0.028806955,-0.029084457,-0.04052657,0.071334645,-0.04315278,0.038521264,0.027656924,0.053088773,-0.014444499,-0.028697714,0.02367218,0.027526904,-0.032864187,-0.012389295,-0.002353951,-0.004426658,-0.09042714,-0.009057201,-0.018697122,0.0002818269,-0.013753866,0.05114049,-0.026753256,-0.0040075104,0.020010257,-0.0058152424,-0.055975415,0.021348203,0.05554502,0.07138858,0.0041350606,0.014900517,0.025766427,-0.010725241,0.014245768,0.011297301,-0.023859086,0.031956743,-0.025900472,-0.024314774,-0.0045541916,0.09558867,0.033638645,-0.0122588165,0.06997246,0.022928031,-0.026059696,0.061355595,-0.010048752,-0.07065234,-0.10534195,0.023102554,0.011649462,0.055052087,0.011649432,-0.035185356,-0.031320903,-0.018659933,0.075123645,-0.05075336,0.009906875,0.07356589,-0.0011413554,-0.03895591,0.031794228,0.03781378,0.00013950939,0.0075343484,0.046061035,0.030458942,-0.03937475,0.060460195,-0.11954172,1.2859162e-33,0.115669936,0.061062995,0.0350418,0.044811036,-0.06771313,0.018501217,-0.10870972,0.060708173,-0.09512797,-0.090005726,0.011169063,-0.085254215,0.005388058,0.03995987,0.067262426,-0.04778547,-0.0016586444,0.04902551,0.046481974,-0.032455474,0.030253211,-0.060735576,-0.08139041,0.022219105,-0.0081642205,0.03641164,-0.013180447,0.05992508,0.07152782,0.012306002,-0.0699711,-0.02464009,-0.030512728,0.049994446,-0.013891297,-0.033333857,-0.076480456,0.020564053,0.008188065,0.0675068,0.107885726,-0.05223746,0.015242999,-0.07902028,0.08551882,-0.010964089,-0.03619128,0.034757737,-0.026155807,0.02118332,0.060353287,0.023193145,0.029417654,0.0021932006,-0.0049824677,0.06072145,-0.036364987,-0.018734075,0.007786541,0.017033292,-0.026048409,0.11711016,-0.03413137,0.04999079,-0.0066238795,0.033236396,-0.04082049,-0.008146637,-0.067719646,0.016828064,-0.047155004,0.026681993,0.030361474,0.052140214,0.043877233,-0.09328168,-0.05837017,-0.02267939,0.11110846,0.0024050009,0.032568388,-0.022716671,0.001348153,-0.053452775,-0.032481253,-0.0192187,-0.0060074567,-0.038911108,-0.069153525,0.061748743,0.04000439,-0.14809681,0.053181324,0.009330201,-0.05314012,-2.90916e-33,0.110898726,-0.08103734,0.023078693,-0.1488177,-0.029843187,0.018876338,0.089392975,-0.059503987,0.016670668,-0.00055028714,0.047653895,-0.010555699,0.034939364,-0.016263409,-0.0050921775,0.061403804,0.05459396,-0.010436055,0.031420965,-0.026384393,0.010227827,0.040423684,0.021092575,0.026828015,0.04582079,0.011720951,0.007628909,0.08719645,0.012712917,0.10990365,-0.057104222,0.017628934,0.053377252,0.036438216,-0.019456051,0.047180813,-0.07494331,-0.021858467,-0.010638391,-0.03234939,-0.11239747,-0.03826302,-0.013588835,0.03692912,0.040943153,0.04828989,-0.03482436,-0.04886193,0.012867306,-0.07439485,-0.0011554891,0.042764083,-0.02527028,0.022106793,-0.046318002,0.05701906,0.03147826,-0.002992705,0.010853551,-0.065722615,-0.067259796,-0.012183964,0.06693678,-0.021005485,0.070063695,0.07511217,-0.038567808,0.08441777,0.010992788,-0.02309338,0.11344282,-0.004813009,0.08279947,0.08026711,-0.033642497,-0.03640775,0.002374992,0.04635774,-0.06789365,-0.028837921,-0.016612822,-0.0014202349,-0.038529396,-0.07890578,-0.052757666,-0.096986175,0.029263454,0.024996864,-0.009273629,0.06650753,-0.026405059,0.051568378,0.0033444574,0.10256468,0.11871781,-4.150178e-08,0.023992147,-0.080946244,-0.018458707,-0.043032877,0.0066539594,-0.013648664,-0.0028014493,-0.059921723,0.036239963,-0.010448291,-0.08156769,0.01825088,0.02338262,0.08061686,0.06104347,-0.076080985,-0.0071445955,0.03835484,-0.030956762,-0.05706658,-0.06666567,0.03230866,-0.06342865,0.008837634,0.013320524,-0.08018174,0.014199048,-0.02206998,0.00399645,0.04499754,-0.016040964,0.09580133,-0.018754646,0.016700689,-0.014002573,0.026439786,-0.03237287,-0.044216607,-0.05521925,0.057417102,0.08833974,0.010048526,-0.06618145,-0.023180386,0.09198571,-0.027104205,-0.05136576,-0.029251317,0.048252214,-0.019836606,0.041582447,0.06370232,-0.011530623,-0.005299668,-0.01197011,0.04616214,-0.03465032,-0.043268923,-0.0594334,-0.070449285,-0.057411272,-0.0056990697,0.21546699,-0.026311453 +2.3.1.209,"The non-activated product, 4-acetamido-4,6-dideoxy-alpha-D-glucose, is part of the O antigens of Shigella dysenteriae type 7 and Escherichia coli O7.",384,1.0,-0.0037968636,-0.07445223,-0.09057013,0.009749062,-0.02891026,0.022536851,0.05739869,0.04129183,0.086623915,-0.04129457,0.026392473,0.037698448,-0.048202395,0.07586177,-0.03996055,0.042036004,0.034338754,0.050450698,-0.046665195,-0.0068459054,0.043387882,-0.014197196,0.032935277,-0.050040495,-0.0069255726,0.012229369,0.057740286,0.009133605,-0.0028229149,-0.07872538,-0.011789512,0.011660922,0.058716886,0.0008468969,0.069672,-0.01047769,0.11528027,-0.044357747,0.04581755,0.025361154,0.028864503,0.036796458,0.022261482,-0.005904106,-0.026746726,-0.0017420161,-0.03218357,0.06958395,0.071633935,-0.10331295,-0.075987644,-0.08625897,-0.007627497,0.002196951,-0.0059636696,-0.03621853,-0.020185987,-0.14281233,-0.010350741,0.0064423284,-0.032783896,-0.00017159735,0.05730422,0.045858987,-0.046681024,-0.06492036,0.018499188,-0.047079604,-0.011890846,0.0066771945,-0.013684277,-0.04797353,0.07643834,0.027858974,0.062172018,-0.029260091,0.04645554,-0.026015267,0.09668938,-0.037386816,0.023527654,-0.05846944,0.039243046,0.13456924,0.021677703,-0.04208457,0.04698086,0.022691179,0.091009535,-0.012514909,-0.029537521,-0.03395139,0.011400451,-0.07024641,-0.02734828,-0.06249652,0.06654135,-0.044574965,0.013417708,0.03623737,-0.047978085,0.0053344388,-0.024235372,-0.032788105,-0.035307243,-0.05095114,0.038268477,0.10890566,-0.025438447,-0.015658733,0.028264444,-0.05666699,0.004836573,0.004355548,-0.16175398,-0.02517066,0.045416594,-0.08362245,-0.049641825,-0.0017794839,-0.010047511,-0.017496515,0.11243212,0.088429004,0.0263325,0.08112756,-0.0030846882,-2.0997821e-34,0.030074783,0.013766281,-0.0030703759,-0.03625579,-0.040729504,0.019003036,-0.024144618,-0.050014373,0.015304594,-0.020695169,-0.1188302,-0.03113615,0.018606529,0.060963266,0.06951582,-0.0031898331,-0.002225969,-0.062261894,0.060508225,0.031167708,0.065825716,0.07108167,-0.0056470404,0.06261168,-0.0048520006,0.0699545,-0.04833428,0.019066293,0.024937816,0.01688922,0.012424511,-0.026926909,-0.03207488,0.039129037,0.037719745,0.05900484,-0.085320294,-0.0026192116,0.02965997,0.07040543,0.032635104,0.01877174,0.027894475,-0.06372709,0.013909211,-0.053187747,-0.05346663,0.05074613,0.017495042,0.085081756,0.020016138,-0.0017904589,0.08421764,-0.10063275,-0.07699301,-0.049915966,-0.053513438,0.045621146,0.061204668,0.016498039,-0.054791797,0.0326151,-0.013977333,-0.0009478615,0.006428664,-0.022456378,0.04025588,-0.020642756,-0.030165903,0.025844356,0.006005153,-0.06544238,0.0481686,0.06386964,-0.032424547,-0.07551258,0.027989175,0.011886999,0.04061835,-0.026272895,0.043567214,-0.029712565,-0.005338711,0.0297189,-0.04026909,0.021540385,-0.043016594,0.045865666,-0.099991895,0.013385576,-0.011523205,0.038122326,-0.10692039,0.03738631,0.04554008,-2.0814666e-33,0.0050553065,-0.04343481,0.03142884,-0.04819251,-0.083643645,0.05284191,-0.047126424,0.04956823,0.0646383,0.043459237,0.101604305,-0.04869614,-0.035165425,-0.051161323,-0.047665883,0.06905297,-0.11427753,0.046485227,-0.07277891,-0.019222524,-0.089894645,0.044260852,-0.0150779085,0.038312145,0.07074601,0.03317062,0.067296885,0.031973172,0.016433109,-0.0062543424,0.068258114,-0.016598934,-0.0082355235,-0.0053946767,-0.059975047,0.043558672,0.030635595,0.0009890911,-0.007468043,-0.0044135926,-0.0105540035,0.036308654,0.046157863,0.09050521,0.025254812,0.0617972,-0.0039903047,0.018268052,0.013685496,0.01377282,-0.027844971,-0.08910848,0.015713993,-0.036780886,-0.023275351,0.007981619,0.05921323,-0.033364564,-0.088336915,0.012970826,0.04670014,-0.07924155,0.0331081,0.01748332,0.060969472,0.0075170514,-0.06021896,0.043832682,0.038541026,-0.055668604,-0.01593863,-0.025010552,-0.09243542,-0.061245974,-0.009856702,-0.060104966,-0.12263425,-0.00047779098,0.032605294,-0.033091616,-0.06661797,-0.070006095,-0.018387748,0.015838906,0.025356932,-0.09359065,0.013094559,0.022030564,0.039293658,0.040681206,0.02506847,0.027596153,0.013588847,-0.01384866,0.0069210855,-3.44418e-08,0.15397467,-0.09890287,0.0013051719,-0.048681892,-0.010429705,0.020790348,-0.12068121,0.010296308,0.061387602,0.0100286985,0.033176366,0.13091981,-0.077026196,-0.06423864,0.0082618715,0.042921294,-0.073233634,-0.024012784,-0.015564739,0.030118775,-0.038557183,-0.0281881,-0.057025917,-0.0101264035,-0.001425883,-0.062317897,0.025690328,-0.0050179437,-0.04764622,-0.117172964,0.022688307,0.03134953,-0.036657017,-0.07853399,-0.09018958,-0.006810517,0.044189528,-0.06983113,-0.0012584971,0.01924821,0.06933797,0.01579193,-0.075975746,-0.012521877,-0.015117098,0.08645975,-0.0784208,0.0049794563,0.0026911865,0.008500932,-0.031536043,-0.020320222,0.025141645,-0.025349153,-0.11473341,0.012059113,0.024819879,-0.05460837,0.108595245,-0.026305838,0.059829943,0.045670822,0.12163795,0.0007625688 +2.3.1.210,"The product, TDP-4-acetamido-4,6-dideoxy-D-galactose, is utilized in the biosynthesis of enterobacterial common antigen (ECA).",384,1.0,0.0028479688,-0.017101824,-0.10732729,-0.061075125,-0.038435645,0.061208546,0.0054828804,0.060504045,0.05423145,0.011941367,0.032520045,-0.06100165,-0.094198264,0.032921277,-0.039631944,0.034126528,0.059309468,0.00018157654,-0.017555919,-0.014172937,0.051805247,-0.023674,-0.008543902,-0.0056620887,-0.05405031,-0.020357743,0.058862474,-0.04266166,-0.02460689,-0.081841595,-0.04361457,-0.060855582,0.08901758,-0.050595514,0.008944168,0.009767821,0.026806485,-0.09697576,0.10873042,0.014042575,0.02371463,-0.020476874,-0.026134161,-0.0056079854,0.019373117,-0.022956207,0.00485154,0.075433336,0.071233176,-0.0660618,-0.0013580421,-0.0035708442,-0.04131402,0.0042661894,-0.013198012,0.04040739,-0.04769153,-0.09183633,0.01735536,0.024012592,0.022496605,0.014228146,0.049061693,0.06088198,-0.03482253,-0.08355486,0.05518597,-0.04833875,-0.017513942,-0.012204873,-0.091293275,-0.07952428,0.0020894478,0.07956985,0.005925687,0.016981686,0.0438883,-0.048172314,0.067967236,0.032191403,0.052096836,0.012752386,-0.087828666,0.045919485,0.0732035,0.0027352208,0.033685055,-0.008494915,0.046501245,0.007988282,0.06574192,-0.0682545,0.03414892,-0.06240676,-0.06575441,-0.01802133,0.03904525,-0.067065425,0.105769746,0.009964358,-0.057320457,0.0075624445,-0.0074781855,-0.07845531,-0.05366258,-0.041947022,0.008355853,0.09206572,0.06094156,0.05041126,-0.053373624,-0.06598323,-0.032597836,0.03201307,-0.09344631,0.08322592,-0.022757735,-0.13062881,0.048377927,-0.01266443,0.042216722,-0.06318279,0.072361805,0.10950861,0.07163292,0.04629624,-0.007549328,-1.5455503e-33,0.06866004,0.04641507,0.025856715,-0.0062691513,-0.007201018,0.02139445,-0.035401244,-0.061616674,-0.022848675,-0.0037926384,-0.10713215,-0.08489141,0.025774905,0.07599484,-0.004514984,0.09808293,-0.08578276,-0.034504678,0.059137706,0.03115045,-0.077668026,0.055958312,-0.008260543,0.032249577,0.047587663,0.065073416,-0.04727994,0.043994404,0.08834014,0.034092806,0.015636435,-0.025956577,-0.068578295,-0.0039810482,0.028919268,0.069165684,0.0089969905,-0.04557014,-0.0014971663,-0.0042577987,0.032148845,0.0558205,0.010787306,0.009703637,0.046595875,-0.10451372,-0.09669361,0.023777995,0.06565253,0.001587803,0.03254535,-0.037093684,0.11262685,-0.029566208,-0.028237402,0.00479688,-0.083706215,0.03975797,0.08668511,0.07082603,-0.068518534,0.066346265,-0.031617574,0.0516702,0.020224957,-0.013449183,0.009074158,-0.03759667,-0.006440942,-0.029450875,-0.0039236885,-0.07753622,0.04574009,0.028041765,-0.0081028445,-0.059355166,0.028577292,0.05399102,0.026681256,-0.021984996,-0.0063528945,0.02764457,-0.025481114,0.018280113,-0.008845127,0.011895883,-0.040300142,-0.02774046,0.018504258,0.035167497,0.03744562,0.0043229163,-0.063919485,0.08602144,-0.0062018945,-1.2944991e-33,0.048754845,-0.056428533,0.010752835,-0.044825286,0.02202781,0.033929437,0.01380702,-0.010814,0.041054007,0.035787333,0.07622066,-0.0425964,0.039705846,-0.09336111,0.043907136,0.018906666,0.01542142,0.034266695,-0.07735034,0.0087847,0.046275288,-0.010276234,0.049314696,-0.031366173,0.05520814,-0.030910285,0.02914166,0.055387907,-0.021881988,-0.023295227,-0.026118565,0.018405152,-0.027700508,-0.014801463,-0.06793752,-0.030950462,-0.028428731,0.08416518,0.021213617,-0.0024058276,-0.035584368,0.055246137,-0.018408824,0.114601985,0.025331939,0.089677215,0.0030539637,0.042211283,0.05804226,0.032417376,-0.010266464,-0.0884669,-0.005587527,-0.042670194,-0.009401943,0.036302548,0.01872284,-0.009523858,-0.017548036,0.007829077,-0.011126245,-0.011979263,0.070778444,-0.05591569,0.10654329,0.012398602,-0.086035274,0.032667506,-0.016085155,-0.022574876,0.054782115,-0.016937884,-0.06609742,0.004820111,0.035375066,-0.07319759,-0.16683741,-0.08148205,0.016631758,0.032805864,-0.012010816,-0.028602822,0.018089546,0.01992524,-0.020837767,-0.06093757,0.042397045,0.052432984,-0.021566339,0.09727895,-0.075124934,-0.015216909,-0.027319906,0.02181043,0.026681151,-3.4739944e-08,0.103202805,-0.06751511,0.035236347,-0.087884046,-0.03249806,0.0010398116,-0.07772052,0.007739763,0.07229186,-0.058657218,-0.011503887,0.13931596,-0.045899488,0.014754312,0.007860725,0.0049060695,-0.05629072,-0.020982232,-0.06656107,0.010408916,-0.027804876,-0.012264974,-0.018190445,-0.012885155,0.0223264,-0.03407984,0.0018884194,0.042877063,-0.04159505,-0.065395154,-0.014762142,0.071648546,-0.012774029,-0.02883867,-0.12353397,0.016779056,-0.006815712,-0.028089585,-0.0013122127,-0.010161081,0.0115829175,-0.05678134,-0.051667225,-0.028463328,-0.042872347,0.032620322,-0.063039236,0.07003025,-0.057451807,-0.016491357,-0.039981708,-0.07206257,-0.053287923,-0.057198714,-0.04087854,-0.062949814,0.046533708,-0.07345313,0.086206414,-0.03219811,0.025073882,0.03936285,0.18437538,0.01684049 +2.4.1.289,"Requires Mn2+ or Mg2+. Isolated from Mycobacterium smegmatis [1] and Mycobacterium tuberculosis [2]. The enzyme catalyses the addition of a rhamnosyl unit to N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol, completing the synthesis of the linkage unit that attaches the arabinogalactan moiety to the peptidoglycan moiety in Mycobacterial cell wall.",384,0.99999994,-0.06992334,-0.050233193,-0.10765597,-0.018779717,0.03488581,-0.013466749,-0.004993376,0.073006675,-0.01649394,0.01790434,0.018466134,-0.013488649,0.13452864,0.035004634,-0.033824794,0.053206686,-0.017134309,0.037797008,-0.011949489,0.018428579,0.04378188,0.03925877,-0.024915991,-0.103666,0.06600442,0.05758849,0.053815622,-0.03300532,-0.015201511,-0.07375301,0.03205223,-0.050506268,0.09217813,-0.12484208,0.1411925,0.05694583,-0.02654785,0.011697457,0.13282846,0.008625682,0.0061101834,0.00786343,0.10571112,-0.059038557,0.031258468,-0.03528496,-0.034451358,0.050806202,0.0660501,0.032130968,-0.0519151,-0.012837561,-0.05305043,0.06480248,0.05204746,-0.0038774665,-0.12654558,-0.021053826,0.014386374,0.0107272435,0.038923573,0.0016602618,0.026461592,-0.02025044,-0.042299103,-0.042438537,-0.056526825,-0.02608949,0.055232696,0.050510254,-0.04097645,-0.018560655,-0.031479027,0.04723491,0.006887702,-0.009887697,0.03896955,-0.060904186,0.03732967,0.07264767,-0.08325478,-0.015841495,0.059490673,0.0033881196,-0.0010783947,0.03005186,0.118379,0.053867072,0.023718653,0.07908644,0.06622573,-0.023902768,0.027517594,-0.045542713,-0.0042509744,-0.035054844,0.007758058,0.015379276,-0.015937181,-0.0073148534,0.004599689,-0.02722734,0.0075961472,-0.09422411,-0.039206833,0.011835132,-0.055608176,0.04655043,0.05565741,-0.020534104,0.004183417,0.019107288,-0.061063427,-0.050249707,-0.008528244,0.07865309,0.07525569,-0.10021919,-0.05480244,-0.052091118,0.05423338,-0.00089713227,0.005692559,-0.0044244137,-0.082979366,0.049395088,-0.046678964,4.2267063e-33,-0.02293481,-0.00809919,0.0031698137,-0.022447634,0.0014752244,-0.034097563,-0.08271686,-0.0012947511,-0.0200347,-0.048389655,-0.10266016,-0.05038101,-0.005332497,0.11255463,-0.11132791,0.002397825,0.01954848,-0.033333894,0.08811858,0.035070483,-0.0063073025,0.09005167,0.0042080926,0.007783414,0.012911848,0.07744848,0.04648857,-0.057069596,0.09254292,0.006656971,0.037086807,-0.043470535,-0.08459018,-0.01717,0.010849736,0.031644206,-0.11344352,-0.061964028,0.005803299,0.031602226,0.015027773,0.008919581,-0.06666782,0.014440008,0.07829067,-0.0071868384,-0.007125758,0.021354381,-0.040896118,-0.0048683784,0.021989623,0.039660145,-0.0012951717,-0.02169723,-0.054045226,-0.039688215,-0.02100658,0.055503935,0.06714316,0.06256063,0.013671838,0.06329426,0.025417792,0.086604185,0.0066448613,-0.026362553,-0.023107743,-0.007891678,-0.008871791,0.018013218,0.0031275637,-0.061396435,0.049954157,0.010410052,0.06389848,-0.057626627,-0.013205332,-0.02396924,0.057592433,-0.026372993,0.008850461,0.06639022,-0.018032309,-0.06279505,-0.06838568,-0.01673587,-0.077465735,-0.066341735,-0.017435737,0.040124174,-0.047151748,-0.044178683,-0.10475259,0.08979019,-0.039609313,-6.237205e-33,0.09734093,-0.15637916,0.09545371,-0.055280525,-0.099623315,0.011150763,0.06191371,-0.039742317,0.059856553,0.06187752,0.055785082,-0.024920197,-0.0068463613,-0.026388468,0.036664527,-0.017986037,0.039583787,0.05677185,-0.04940874,0.003025874,-0.0717832,0.09912879,0.04016419,-0.033273485,-0.004467096,0.033996858,-0.0036174068,0.002504927,0.063938774,0.05697576,-0.02902373,0.024693174,-0.052050643,-0.0805726,-0.10011258,0.058958054,-0.05798026,-0.058156382,0.024947915,-0.06086495,0.011791125,0.06436888,0.0056234323,0.07453479,0.010914152,-0.017045202,-0.073029175,0.015872195,-0.041807875,-0.063951366,-0.043280844,0.0254169,-0.011091596,-0.05985263,0.057616163,0.031923622,-0.001896427,0.009336865,0.054392755,-0.040388837,-0.05463232,-0.092795976,0.0020265856,-0.042176344,0.071344696,0.1528297,0.058814805,0.03399104,0.010509006,-0.03539491,0.057495516,0.018074952,0.031002557,0.03534558,0.039166186,-0.005145988,-0.027347963,0.0019237953,-0.01183388,-0.059746068,0.0027445743,-0.047566194,-0.02185243,-0.0736556,0.035780523,-0.10271467,0.04405919,0.12387214,-0.040041976,0.047972705,-0.010083337,-0.004652353,-0.07093655,0.03483692,0.05647353,-4.4659107e-08,0.0057981936,-0.07428693,0.043844406,-0.08295932,-0.019704305,0.07198157,-0.06735466,-0.042822663,0.025857028,-0.011007603,0.04088954,0.015733657,0.0018185765,-0.021529641,-0.01978791,0.05141303,-0.05423018,-0.030753717,0.02813345,-0.018391402,-0.08057733,0.03185542,-0.05826112,0.03839467,-0.0011955302,-0.019896585,0.033943973,0.050028168,-0.030508023,-0.003287463,0.02583125,0.019719051,-0.07013367,-0.06258329,-0.07144471,-0.011843718,-0.02084867,-0.052380774,0.03815735,-0.029453183,0.026802462,0.010969312,-0.030408187,0.018091537,-0.0589571,-0.01667312,-0.05572107,0.011825637,-0.08043979,0.01368023,0.0257571,-0.039415218,-0.033796772,-0.05161868,-0.033842415,0.04258028,-0.0141946385,-0.075872995,-0.04858951,-0.0062132417,-0.0012557079,0.0012319491,0.09378084,-0.01957778 +2.4.1.290,Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway.,384,1.0,-0.027744778,0.018385416,-0.11108243,0.021446874,0.0049547264,0.043464202,-0.041303117,0.012134648,0.061302517,-0.019286921,0.061859746,0.00253857,0.024521617,0.081448264,0.020857397,-0.015008069,-0.0043795067,0.017163554,-0.04367812,-0.02032597,-0.039286,0.07664937,0.038453426,-0.06821934,0.0033546009,-0.054478772,0.08554149,-0.03237804,-0.000902486,-0.012026851,0.0017075988,-0.031845428,-0.040165402,-0.09087569,0.10805533,0.012410035,-0.028694041,-0.057790402,0.14869091,0.039422784,0.014815008,0.0011651426,0.067126006,-0.077828586,-0.031986915,0.0070542926,-0.008388698,0.061409652,0.101301335,-0.05288718,-0.07874027,-0.026875287,-0.01861798,0.0133327935,0.05263894,0.04002314,-0.0408099,-0.018988427,0.011101787,0.048595,0.0041890144,0.05770811,0.11407726,-0.020684384,-0.102287,-0.068143085,0.027642924,-0.010622733,0.04483727,0.018415084,-0.068785146,-0.039378345,0.0313839,-0.02204115,-0.016261134,-0.02131186,0.004289336,0.055760123,0.05892828,-0.009172667,-0.0060313544,-0.009957948,0.14844555,0.010103235,-0.08892335,-0.031714268,0.049869727,0.074498884,0.09602652,0.062785506,-0.013741214,-0.032268267,0.022972679,-0.05309896,-0.045620475,-0.080542706,0.05633755,0.027061049,0.013734122,-0.013526715,-0.012812923,-0.05831364,0.10287487,-0.028342107,-0.086411804,0.027894266,0.09621372,0.08616292,0.05598804,-0.032246105,-0.026491294,0.09276958,0.029780107,-0.07723438,-0.07242756,-0.017548425,0.059333943,-0.029880766,-0.012381129,0.044578608,0.0804016,-0.032427356,0.09789566,0.013640588,-0.012474195,0.057688225,-0.030238258,-4.976212e-34,0.0765464,0.03810261,0.078978345,-0.022685349,0.049888775,-0.0513423,-0.053543046,-0.075546235,-0.0802513,-0.006555458,-0.06125726,-0.06982872,-0.0138955675,0.06753776,0.020743735,0.030317705,-0.09196018,-0.012552031,0.05244816,-0.046629667,0.0022598067,0.007898458,0.047372825,-0.093167685,0.036587436,0.023490043,0.027766306,0.020392608,0.0057023624,-0.021869002,0.05135052,-0.076271646,-0.10551912,-0.008037435,0.08632195,0.018431714,-0.022914639,-0.017248925,-0.008279961,-0.04912961,0.0033576505,0.09234792,-0.0007185602,-0.018697178,0.018107971,-0.023039594,-0.04984953,0.03369682,0.061911006,0.04448619,0.016416654,-0.04170328,0.04255065,0.03360604,-0.067183055,0.02402908,0.04309744,0.016547706,0.04379668,0.052787736,-0.022443365,0.062208477,-0.030652866,-0.012098245,0.046869565,0.0129809445,0.012269045,0.0073377965,0.02622401,-0.03000155,-0.0015761713,-0.02207034,0.094467975,0.032042082,-0.044399623,-0.06571607,-0.00132857,-0.039849482,0.029797547,-0.018040342,-0.030332083,0.0043634945,-0.001944678,-0.019489842,-0.08145869,0.030243738,-0.09172163,-0.032506276,-0.011499445,0.057553694,0.04399021,0.016436737,-0.056669287,-0.0039635943,-0.014925812,-1.2100887e-33,0.043700457,-0.013491187,0.062322926,-0.060908347,-0.05034451,-0.041367736,-0.025445644,-0.03882529,0.009492213,-0.004822238,-0.0068983585,0.08271312,0.08656272,-0.0065116137,0.052782547,0.035649408,0.027289098,0.078713976,-0.028792728,-0.046818588,0.056452554,-0.047341444,-0.053757362,-0.10250222,-0.0043904856,0.0062141484,0.03776899,0.11170505,-0.027032085,0.003891128,0.047168806,0.03465062,-0.089512154,-0.12884311,0.045879044,-0.045399085,-0.07929899,-0.028363274,-0.0028769686,-0.13458334,0.04687283,0.04032676,-0.01670106,0.0797996,0.020211121,0.058946993,-0.056955244,-0.041354008,-0.032639794,0.009141498,-0.10109658,-0.0520914,-0.02999763,-0.04274978,-0.01019751,0.03211152,0.019155754,0.031141326,-0.0070208255,-0.02660843,0.012672343,0.018761428,0.014661665,0.005613988,0.063391745,0.026125308,0.05153083,0.00034115394,0.10036847,-0.070650406,0.05545179,0.0079370905,0.008066585,0.06947224,-0.013874777,0.028384142,-0.0920702,-0.011600869,-0.0070387265,0.020570679,0.10338226,-0.06551433,-0.023799384,-0.068823144,0.05643251,-0.016040897,0.058723174,0.11336757,0.042927355,0.015234517,0.02003133,-0.05545976,-0.0021499814,0.07064398,-0.03272654,-2.0954381e-08,-0.021503763,-0.11358849,-0.020426705,-0.06776843,-0.06815409,0.04049961,-0.03935522,0.0037241257,-0.01503337,-0.013002537,0.017980145,0.017699583,-0.05525096,0.015297324,-0.04647773,0.09118837,-0.090951785,-0.01712048,-0.008192939,0.037164703,-0.1105839,0.021723831,0.0060308636,0.06849712,0.002480712,-0.05401336,-0.0077026645,0.094231665,-0.036702476,-0.07518471,0.023449127,0.06821256,-0.04619008,0.010536587,-0.10892281,-0.05021941,-0.022123624,0.011399803,-0.013226509,0.024766803,0.011073811,-0.019192645,-0.030938398,-0.01475575,-0.02211003,0.040405173,-0.06608647,0.0254686,-0.06580764,-0.079134636,0.015736667,-0.0076612,-0.03611455,0.01683709,-0.10790916,0.029651465,0.013454666,0.03204511,0.027138673,-0.040290207,-0.09367788,-0.01311271,0.05623256,-0.02532384 +2.4.1.291,Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway.,384,1.0,-0.027744778,0.018385416,-0.11108243,0.021446874,0.0049547264,0.043464202,-0.041303117,0.012134648,0.061302517,-0.019286921,0.061859746,0.00253857,0.024521617,0.081448264,0.020857397,-0.015008069,-0.0043795067,0.017163554,-0.04367812,-0.02032597,-0.039286,0.07664937,0.038453426,-0.06821934,0.0033546009,-0.054478772,0.08554149,-0.03237804,-0.000902486,-0.012026851,0.0017075988,-0.031845428,-0.040165402,-0.09087569,0.10805533,0.012410035,-0.028694041,-0.057790402,0.14869091,0.039422784,0.014815008,0.0011651426,0.067126006,-0.077828586,-0.031986915,0.0070542926,-0.008388698,0.061409652,0.101301335,-0.05288718,-0.07874027,-0.026875287,-0.01861798,0.0133327935,0.05263894,0.04002314,-0.0408099,-0.018988427,0.011101787,0.048595,0.0041890144,0.05770811,0.11407726,-0.020684384,-0.102287,-0.068143085,0.027642924,-0.010622733,0.04483727,0.018415084,-0.068785146,-0.039378345,0.0313839,-0.02204115,-0.016261134,-0.02131186,0.004289336,0.055760123,0.05892828,-0.009172667,-0.0060313544,-0.009957948,0.14844555,0.010103235,-0.08892335,-0.031714268,0.049869727,0.074498884,0.09602652,0.062785506,-0.013741214,-0.032268267,0.022972679,-0.05309896,-0.045620475,-0.080542706,0.05633755,0.027061049,0.013734122,-0.013526715,-0.012812923,-0.05831364,0.10287487,-0.028342107,-0.086411804,0.027894266,0.09621372,0.08616292,0.05598804,-0.032246105,-0.026491294,0.09276958,0.029780107,-0.07723438,-0.07242756,-0.017548425,0.059333943,-0.029880766,-0.012381129,0.044578608,0.0804016,-0.032427356,0.09789566,0.013640588,-0.012474195,0.057688225,-0.030238258,-4.976212e-34,0.0765464,0.03810261,0.078978345,-0.022685349,0.049888775,-0.0513423,-0.053543046,-0.075546235,-0.0802513,-0.006555458,-0.06125726,-0.06982872,-0.0138955675,0.06753776,0.020743735,0.030317705,-0.09196018,-0.012552031,0.05244816,-0.046629667,0.0022598067,0.007898458,0.047372825,-0.093167685,0.036587436,0.023490043,0.027766306,0.020392608,0.0057023624,-0.021869002,0.05135052,-0.076271646,-0.10551912,-0.008037435,0.08632195,0.018431714,-0.022914639,-0.017248925,-0.008279961,-0.04912961,0.0033576505,0.09234792,-0.0007185602,-0.018697178,0.018107971,-0.023039594,-0.04984953,0.03369682,0.061911006,0.04448619,0.016416654,-0.04170328,0.04255065,0.03360604,-0.067183055,0.02402908,0.04309744,0.016547706,0.04379668,0.052787736,-0.022443365,0.062208477,-0.030652866,-0.012098245,0.046869565,0.0129809445,0.012269045,0.0073377965,0.02622401,-0.03000155,-0.0015761713,-0.02207034,0.094467975,0.032042082,-0.044399623,-0.06571607,-0.00132857,-0.039849482,0.029797547,-0.018040342,-0.030332083,0.0043634945,-0.001944678,-0.019489842,-0.08145869,0.030243738,-0.09172163,-0.032506276,-0.011499445,0.057553694,0.04399021,0.016436737,-0.056669287,-0.0039635943,-0.014925812,-1.2100887e-33,0.043700457,-0.013491187,0.062322926,-0.060908347,-0.05034451,-0.041367736,-0.025445644,-0.03882529,0.009492213,-0.004822238,-0.0068983585,0.08271312,0.08656272,-0.0065116137,0.052782547,0.035649408,0.027289098,0.078713976,-0.028792728,-0.046818588,0.056452554,-0.047341444,-0.053757362,-0.10250222,-0.0043904856,0.0062141484,0.03776899,0.11170505,-0.027032085,0.003891128,0.047168806,0.03465062,-0.089512154,-0.12884311,0.045879044,-0.045399085,-0.07929899,-0.028363274,-0.0028769686,-0.13458334,0.04687283,0.04032676,-0.01670106,0.0797996,0.020211121,0.058946993,-0.056955244,-0.041354008,-0.032639794,0.009141498,-0.10109658,-0.0520914,-0.02999763,-0.04274978,-0.01019751,0.03211152,0.019155754,0.031141326,-0.0070208255,-0.02660843,0.012672343,0.018761428,0.014661665,0.005613988,0.063391745,0.026125308,0.05153083,0.00034115394,0.10036847,-0.070650406,0.05545179,0.0079370905,0.008066585,0.06947224,-0.013874777,0.028384142,-0.0920702,-0.011600869,-0.0070387265,0.020570679,0.10338226,-0.06551433,-0.023799384,-0.068823144,0.05643251,-0.016040897,0.058723174,0.11336757,0.042927355,0.015234517,0.02003133,-0.05545976,-0.0021499814,0.07064398,-0.03272654,-2.0954381e-08,-0.021503763,-0.11358849,-0.020426705,-0.06776843,-0.06815409,0.04049961,-0.03935522,0.0037241257,-0.01503337,-0.013002537,0.017980145,0.017699583,-0.05525096,0.015297324,-0.04647773,0.09118837,-0.090951785,-0.01712048,-0.008192939,0.037164703,-0.1105839,0.021723831,0.0060308636,0.06849712,0.002480712,-0.05401336,-0.0077026645,0.094231665,-0.036702476,-0.07518471,0.023449127,0.06821256,-0.04619008,0.010536587,-0.10892281,-0.05021941,-0.022123624,0.011399803,-0.013226509,0.024766803,0.011073811,-0.019192645,-0.030938398,-0.01475575,-0.02211003,0.040405173,-0.06608647,0.0254686,-0.06580764,-0.079134636,0.015736667,-0.0076612,-0.03611455,0.01683709,-0.10790916,0.029651465,0.013454666,0.03204511,0.027138673,-0.040290207,-0.09367788,-0.01311271,0.05623256,-0.02532384 +2.4.1.292,Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway.,384,1.0,-0.027744778,0.018385416,-0.11108243,0.021446874,0.0049547264,0.043464202,-0.041303117,0.012134648,0.061302517,-0.019286921,0.061859746,0.00253857,0.024521617,0.081448264,0.020857397,-0.015008069,-0.0043795067,0.017163554,-0.04367812,-0.02032597,-0.039286,0.07664937,0.038453426,-0.06821934,0.0033546009,-0.054478772,0.08554149,-0.03237804,-0.000902486,-0.012026851,0.0017075988,-0.031845428,-0.040165402,-0.09087569,0.10805533,0.012410035,-0.028694041,-0.057790402,0.14869091,0.039422784,0.014815008,0.0011651426,0.067126006,-0.077828586,-0.031986915,0.0070542926,-0.008388698,0.061409652,0.101301335,-0.05288718,-0.07874027,-0.026875287,-0.01861798,0.0133327935,0.05263894,0.04002314,-0.0408099,-0.018988427,0.011101787,0.048595,0.0041890144,0.05770811,0.11407726,-0.020684384,-0.102287,-0.068143085,0.027642924,-0.010622733,0.04483727,0.018415084,-0.068785146,-0.039378345,0.0313839,-0.02204115,-0.016261134,-0.02131186,0.004289336,0.055760123,0.05892828,-0.009172667,-0.0060313544,-0.009957948,0.14844555,0.010103235,-0.08892335,-0.031714268,0.049869727,0.074498884,0.09602652,0.062785506,-0.013741214,-0.032268267,0.022972679,-0.05309896,-0.045620475,-0.080542706,0.05633755,0.027061049,0.013734122,-0.013526715,-0.012812923,-0.05831364,0.10287487,-0.028342107,-0.086411804,0.027894266,0.09621372,0.08616292,0.05598804,-0.032246105,-0.026491294,0.09276958,0.029780107,-0.07723438,-0.07242756,-0.017548425,0.059333943,-0.029880766,-0.012381129,0.044578608,0.0804016,-0.032427356,0.09789566,0.013640588,-0.012474195,0.057688225,-0.030238258,-4.976212e-34,0.0765464,0.03810261,0.078978345,-0.022685349,0.049888775,-0.0513423,-0.053543046,-0.075546235,-0.0802513,-0.006555458,-0.06125726,-0.06982872,-0.0138955675,0.06753776,0.020743735,0.030317705,-0.09196018,-0.012552031,0.05244816,-0.046629667,0.0022598067,0.007898458,0.047372825,-0.093167685,0.036587436,0.023490043,0.027766306,0.020392608,0.0057023624,-0.021869002,0.05135052,-0.076271646,-0.10551912,-0.008037435,0.08632195,0.018431714,-0.022914639,-0.017248925,-0.008279961,-0.04912961,0.0033576505,0.09234792,-0.0007185602,-0.018697178,0.018107971,-0.023039594,-0.04984953,0.03369682,0.061911006,0.04448619,0.016416654,-0.04170328,0.04255065,0.03360604,-0.067183055,0.02402908,0.04309744,0.016547706,0.04379668,0.052787736,-0.022443365,0.062208477,-0.030652866,-0.012098245,0.046869565,0.0129809445,0.012269045,0.0073377965,0.02622401,-0.03000155,-0.0015761713,-0.02207034,0.094467975,0.032042082,-0.044399623,-0.06571607,-0.00132857,-0.039849482,0.029797547,-0.018040342,-0.030332083,0.0043634945,-0.001944678,-0.019489842,-0.08145869,0.030243738,-0.09172163,-0.032506276,-0.011499445,0.057553694,0.04399021,0.016436737,-0.056669287,-0.0039635943,-0.014925812,-1.2100887e-33,0.043700457,-0.013491187,0.062322926,-0.060908347,-0.05034451,-0.041367736,-0.025445644,-0.03882529,0.009492213,-0.004822238,-0.0068983585,0.08271312,0.08656272,-0.0065116137,0.052782547,0.035649408,0.027289098,0.078713976,-0.028792728,-0.046818588,0.056452554,-0.047341444,-0.053757362,-0.10250222,-0.0043904856,0.0062141484,0.03776899,0.11170505,-0.027032085,0.003891128,0.047168806,0.03465062,-0.089512154,-0.12884311,0.045879044,-0.045399085,-0.07929899,-0.028363274,-0.0028769686,-0.13458334,0.04687283,0.04032676,-0.01670106,0.0797996,0.020211121,0.058946993,-0.056955244,-0.041354008,-0.032639794,0.009141498,-0.10109658,-0.0520914,-0.02999763,-0.04274978,-0.01019751,0.03211152,0.019155754,0.031141326,-0.0070208255,-0.02660843,0.012672343,0.018761428,0.014661665,0.005613988,0.063391745,0.026125308,0.05153083,0.00034115394,0.10036847,-0.070650406,0.05545179,0.0079370905,0.008066585,0.06947224,-0.013874777,0.028384142,-0.0920702,-0.011600869,-0.0070387265,0.020570679,0.10338226,-0.06551433,-0.023799384,-0.068823144,0.05643251,-0.016040897,0.058723174,0.11336757,0.042927355,0.015234517,0.02003133,-0.05545976,-0.0021499814,0.07064398,-0.03272654,-2.0954381e-08,-0.021503763,-0.11358849,-0.020426705,-0.06776843,-0.06815409,0.04049961,-0.03935522,0.0037241257,-0.01503337,-0.013002537,0.017980145,0.017699583,-0.05525096,0.015297324,-0.04647773,0.09118837,-0.090951785,-0.01712048,-0.008192939,0.037164703,-0.1105839,0.021723831,0.0060308636,0.06849712,0.002480712,-0.05401336,-0.0077026645,0.094231665,-0.036702476,-0.07518471,0.023449127,0.06821256,-0.04619008,0.010536587,-0.10892281,-0.05021941,-0.022123624,0.011399803,-0.013226509,0.024766803,0.011073811,-0.019192645,-0.030938398,-0.01475575,-0.02211003,0.040405173,-0.06608647,0.0254686,-0.06580764,-0.079134636,0.015736667,-0.0076612,-0.03611455,0.01683709,-0.10790916,0.029651465,0.013454666,0.03204511,0.027138673,-0.040290207,-0.09367788,-0.01311271,0.05623256,-0.02532384 +2.4.1.293,"Isolated from the bacterium Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. +",384,1.0,-0.036399998,0.03033079,-0.120171,0.024784204,0.011804996,0.047725067,-0.035683386,0.006287905,0.06101742,-0.018483732,0.059357867,-0.0075679314,0.010339706,0.06421545,0.010449925,-0.027374338,-0.010612246,0.021404248,-0.037574492,-0.024029264,-0.032460455,0.07930064,0.04307155,-0.06748851,0.009747888,-0.04890214,0.08604503,-0.028690442,0.006463168,-0.014349748,-0.0008000006,-0.031045273,-0.032612048,-0.09010708,0.112689346,0.019347083,-0.024571568,-0.063009836,0.14361648,0.03686119,0.013984476,0.0073272097,0.063701995,-0.077657275,-0.032570727,0.014110151,-0.0015912611,0.073169865,0.09545917,-0.058603026,-0.075905144,-0.026679423,-0.012548657,0.016562065,0.05704932,0.04201409,-0.03779393,-0.019195274,0.009295828,0.04642397,0.011496336,0.06507109,0.1069227,-0.018330578,-0.10124418,-0.073015526,0.04226155,-0.019883722,0.052674808,0.0074754306,-0.07376006,-0.040774345,0.028780371,-0.028120292,-0.012717257,-0.012311594,0.0022975714,0.05118016,0.06575951,-0.007926939,-0.0025519405,-0.006139989,0.14637454,0.014151705,-0.09511255,-0.038832355,0.048954062,0.07843292,0.100383855,0.06283203,-0.015963012,-0.04202402,0.014814326,-0.057639565,-0.05465508,-0.07601243,0.053032212,0.020766215,0.020675682,-0.009547099,-0.00832383,-0.051054098,0.099780984,-0.035129238,-0.097248144,0.026470713,0.08476974,0.094671905,0.06397764,-0.028540269,-0.030943133,0.090681136,0.026434481,-0.074420884,-0.06814251,-0.0182343,0.0598529,-0.03282191,-0.016759817,0.042568084,0.07662003,-0.033142854,0.09865171,0.02221084,-0.026350861,0.05381458,-0.04670381,-4.841997e-34,0.08028828,0.031361874,0.07749856,-0.02429429,0.046792492,-0.049029462,-0.059089277,-0.081831805,-0.08212263,-0.012717626,-0.06025778,-0.06686095,-0.014309735,0.06901214,0.011708418,0.02927419,-0.084994145,-0.02201037,0.05624115,-0.046497807,0.0071985605,0.019709524,0.052925084,-0.08737074,0.03897685,0.02151893,0.03362714,0.019664008,0.0038600322,-0.021328488,0.053989395,-0.08158938,-0.10504669,-0.012837116,0.087092064,0.0192583,-0.024146942,-0.018499982,-0.009130649,-0.033768684,0.010059864,0.089555785,0.004831256,-0.022351053,0.027086483,-0.013691173,-0.04874793,0.03878479,0.06317792,0.049058314,0.0036399253,-0.040445555,0.04508891,0.030610807,-0.07570354,0.032106493,0.043650143,0.01800784,0.04304187,0.055072043,-0.024128659,0.07314512,-0.030312326,-0.016169742,0.043337487,0.019529473,0.003745305,0.0005751626,0.01866149,-0.039593123,-0.005373562,-0.02622563,0.094285175,0.03710738,-0.03662337,-0.06282938,0.0013282655,-0.03747304,0.028181173,-0.020132998,-0.032527152,0.00626736,-0.01087525,-0.019014195,-0.0873689,0.020347716,-0.09198651,-0.029515572,-0.008214648,0.05722756,0.033951905,0.012380855,-0.047800355,-0.0023387305,-0.014244035,-1.1809363e-33,0.044236343,-0.021065114,0.05788263,-0.05490617,-0.04137464,-0.039021924,-0.023033254,-0.04466684,0.00025875834,-0.005722859,-0.007718922,0.080577664,0.08666628,-0.008022784,0.047532577,0.03047687,0.034071866,0.08326079,-0.029533155,-0.03426027,0.052188747,-0.04463347,-0.055873413,-0.11203506,-0.0043835444,0.004924558,0.037597764,0.11107457,-0.016492857,0.0023007905,0.04164188,0.037849262,-0.09763347,-0.11681071,0.032532223,-0.03941509,-0.073267475,-0.034473874,-0.002943389,-0.120921224,0.047648635,0.045011904,-0.017033087,0.07229317,0.024979178,0.06527589,-0.058330584,-0.037037708,-0.03536185,0.011730972,-0.09733697,-0.052517537,-0.028628452,-0.043944035,-0.009996489,0.03453517,0.0075581875,0.036665905,-0.0076049217,-0.022162998,0.0133666815,0.012588022,0.020269439,0.0063287546,0.06216282,0.024639022,0.04949042,0.008978706,0.089370325,-0.07568519,0.059371464,0.005059889,0.01510694,0.07470557,-0.010249978,0.026504518,-0.09922883,-0.01599443,-0.009908818,0.015087994,0.09838851,-0.067122824,-0.031624198,-0.06643748,0.06069266,-0.017821835,0.06330409,0.119267724,0.04477996,0.01959573,0.012758088,-0.055104617,-0.0066255345,0.08075106,-0.023345917,-2.1621778e-08,-0.022725642,-0.110527106,-0.01397846,-0.07152246,-0.062147524,0.04407756,-0.030706806,0.007316793,-0.012154774,-0.017022688,0.016786046,0.02250446,-0.050004482,0.0068979296,-0.04718045,0.09062884,-0.100552835,-0.014679076,-0.010045748,0.039881643,-0.09965406,0.024415853,-0.0018582519,0.070359424,0.0050814115,-0.052038457,-0.0020343428,0.07890904,-0.044309597,-0.079669364,0.01617659,0.076816514,-0.039510906,0.006201078,-0.11227591,-0.042316206,-0.028894624,0.019860715,-0.017568441,0.028982904,0.010254135,-0.022975447,-0.029813247,-0.0023055736,-0.012662338,0.03989817,-0.07168533,0.034095947,-0.07498242,-0.07041198,0.021322593,-0.007848525,-0.03306223,0.019305605,-0.110228,0.024563245,0.0033474225,0.024678325,0.026087515,-0.03648974,-0.083145544,-0.010225417,0.06085867,-0.027535375 +2.4.2.48,"Archaeal tRNAs contain the modified nucleoside archaeosine at position 15. This archaeal enzyme catalyses the exchange of guanine at position 15 of tRNA with the base preQ0, which is ultimately modified to form the nucleoside archaeosine (cf. EC 2.6.1.97) [1].",384,1.0,-0.06493618,-0.060260944,-0.047795292,-0.034327656,0.052989367,-0.040791463,-0.011598753,-0.004011906,0.030444067,0.01248684,0.027656224,-0.021087915,-0.10695577,0.02485577,-0.07742535,0.0051628216,-0.09689539,0.018357424,0.08127355,-0.0052318685,0.026646024,0.057808574,-0.035845388,0.02813109,0.034556396,0.021733027,0.044983897,-0.08184092,0.0074731936,-0.09151118,-0.04862844,-0.050234944,0.08942929,-0.011945999,-0.0022835138,0.12402072,-0.10812186,-0.021512482,0.098763056,-0.025127495,0.042490616,0.0020195511,0.097451255,-0.029947791,-0.056535967,0.032989737,0.037117366,0.020698635,-0.0002768531,0.031134486,0.0009271163,-0.048925195,-0.06904678,0.029854752,0.03755583,0.120938115,-0.059051916,-0.047377463,0.04084434,0.014918482,0.107996605,0.013727629,0.026661972,-0.04574124,0.013583947,-0.043618362,0.0747307,-0.0029233245,0.02965297,-0.00910342,0.021634748,0.03754033,-0.042933825,0.027288359,-0.064789,0.13727145,0.013176137,-0.048905905,0.026447233,0.031466335,-0.0061975815,0.051196314,0.048614364,-0.023386773,0.07812267,0.0062212273,-0.03900402,0.04953733,0.051120713,0.020452881,0.09239561,0.060022946,0.026394544,-0.07956041,-0.012508277,0.055586427,-0.010184108,0.040058464,-0.002840252,-0.02688329,0.029087432,0.05244014,-0.03604362,-0.07419647,-0.032462563,-0.003752414,0.038091812,0.0064420244,-0.01017119,0.081552945,-0.007133241,-0.0019016524,0.027471326,-0.011711541,-0.016192734,0.08060942,0.020661712,-0.016397044,-0.059309255,-0.018015277,-0.065702714,-0.0069898395,0.030596288,0.015994169,-0.08014862,0.02144977,-0.05724364,3.643778e-33,0.0341505,-0.022671944,-0.03259183,-0.015035478,0.056773204,0.007815289,-0.06206692,-0.01295121,-0.06666548,-0.0031374693,-0.11942897,-0.03104909,0.033533834,-0.03616045,-0.0495473,-0.00538636,-0.02239201,0.02645099,0.010146206,-0.0396666,-0.04279833,0.08385789,-0.039316714,0.0070620473,0.06327774,-0.016043803,-0.02483405,-0.024251882,0.027237361,-0.04710927,-0.026493955,-0.060069293,-0.089934945,-0.0047588707,0.09601801,-0.022595188,-0.061159965,-0.00826414,-0.04864731,0.050528314,0.006185178,0.023628926,-0.016426716,0.0005660856,-0.0070494125,0.025578832,0.0046094013,0.06493209,0.016250657,-0.011028929,-0.018743435,0.008374487,-0.05419152,-0.028798893,-0.049454696,-0.021826532,0.024021897,-0.007976919,0.05910284,0.031968094,0.068016194,0.02432385,0.0376149,-0.0025901764,-0.02911838,0.06943801,-0.07110565,-0.034939863,0.06515698,0.0531514,-0.01353494,-0.057610214,0.041661378,0.016430601,0.0047542728,-0.03231408,-0.079377525,-0.08452163,-0.004479204,-0.0180705,-0.04400744,-0.036805224,0.03978864,0.017837455,-0.0149978725,0.009187425,-0.00499803,-0.017300284,0.0727803,0.04985402,0.031522777,-0.04841887,-0.05230721,0.0353756,0.004972482,-2.5867293e-33,0.059031684,-0.13725443,0.0007490674,-0.079484515,-0.12484477,0.039304476,0.00088967395,-0.1407658,-0.034741532,-0.042054605,0.100114524,-0.0019449082,-0.0017418328,-0.017999642,0.06227098,-0.056383993,0.06178248,0.0074453154,-0.007895072,-0.0024699452,0.049913608,0.026712624,-0.026016861,0.029482746,0.026764464,0.01312071,0.04391756,0.04229326,0.06308377,0.03894548,-0.07618659,0.023739602,0.019580273,0.06185806,-0.05881674,-0.0029065702,0.030377548,-0.02203091,0.029066598,-0.030598471,0.04958085,0.029627727,0.01474508,0.089847624,0.005785979,0.03880705,-0.00793505,-0.024263106,-0.07519718,-0.09347551,0.07863606,-0.019221839,0.026605528,-0.021221912,0.026401727,0.051460866,-0.051327445,0.0038210095,0.060590897,-0.035457097,-0.016556172,-0.08058086,-0.012903421,-0.09169173,0.040558852,0.053250503,-0.08414278,0.107732676,-0.07794359,-0.033956308,-0.035817094,-0.0018210174,0.02329073,0.07590976,0.0136961695,-0.04449404,0.051365912,-0.0392727,0.082860954,-0.14959511,-0.047647964,0.02303349,-0.037841015,-0.082527526,0.03449811,-0.0149977105,0.0799174,0.093358316,-0.0071029346,0.09714104,-0.03344056,0.009725793,-0.012842957,0.03342645,0.064271614,-3.268242e-08,-0.03343937,0.0066486346,0.02571106,0.012132255,0.05492256,0.100969866,0.021641355,0.067194596,0.041735776,-0.029322412,-0.036963318,0.0439527,0.05063676,0.025079831,0.048345808,0.10178401,-0.111773856,-0.03995077,0.0005018157,-0.057212196,-0.03542545,0.060398463,-0.11451749,-0.015626613,-0.030796561,0.0041298717,0.037170295,0.07660173,-0.05662725,-0.033042476,-0.0042559267,-0.017959887,0.03398062,-0.024614293,0.05284801,0.06892363,0.016695943,-0.055087388,-0.047093585,-0.016784472,-0.06420351,0.002002475,-0.07932101,-0.018046074,-0.0669896,-0.016872456,-0.03217416,0.059847843,-0.01351794,0.08832853,0.1014285,-0.013822776,0.07900421,-0.0023771375,-0.0054461746,-0.07556106,0.025646083,-0.060884573,-0.11526494,0.05797945,0.04929926,-0.0583288,0.12210409,-0.04324797 +2.4.99.18,"Occurs in eukaryotes that form a glycoprotein by the transfer of a glucosyl-mannosyl-glucosamine polysaccharide to the side-chain of an L-asparagine residue in the sequence -Asn-Xaa-Ser- or -Asn-Xaa-Thr- (Xaa not Pro) in nascent polypeptide chains. The basic oligosaccharide is the tetradecasaccharide Glc3Man9GlcNAc2 (for diagram {polysacc/Dol14}). However, smaller oligosaccharides derived from it and oligosaccharides with additional monosaccharide units attached may be involved. See ref [2] for a review of N-glycoproteins in eukaryotes. Man3GlcNAc2 seems to be common for all of the oligosaccharides involved with the terminal N-acetylglucosamine linked to the protein L-asparagine. Occurs on the cytosolic face of the endoplasmic reticulum. The dolichol involved normally has 14-21 isoprenoid units with two trans double-bonds at the omega end, and the rest of the double-bonds in cis form.",384,1.0,-0.035285294,-0.11780994,-0.09525005,-0.024556905,0.00059474737,-0.013875522,0.006042422,0.057887413,0.1106258,0.026944058,0.038984604,0.02912987,-0.032214433,0.0667139,-0.078074045,-0.024862979,0.020519892,-0.02238113,-0.0056296615,-0.03000795,0.101284005,-0.0067384774,0.0023550875,-0.0044083786,0.0129382955,-0.078000225,-0.018672734,-0.07293039,0.005845098,-0.0655839,-0.03587718,-0.079301745,-0.010614124,-0.0029651348,0.06998565,0.06534355,-0.03303849,-0.012799961,0.009127233,-0.02814586,0.030315546,-0.0021932803,-0.007868465,-0.04639029,-0.079970546,-0.002811186,-0.0371668,0.028979624,0.0160624,0.06880394,0.009478083,-0.07832402,-0.018379422,0.067085,0.088583864,0.04084096,-0.075710505,0.005676594,0.052560765,0.09085152,-0.06764156,0.027299287,0.009237278,-0.023773026,-0.02009659,-0.037645444,0.063442595,-0.041428912,-0.08096787,0.08447228,0.029510597,0.022120578,0.028304487,0.014534819,0.03482143,0.07556543,-0.038221285,-0.00084914174,-0.009931941,-0.011910119,0.06864844,0.09777085,0.053501006,0.0699975,-0.037295163,-0.07554813,-0.011601431,0.06389864,0.047748115,-0.00046777402,-0.031090762,-0.012437816,0.010007237,-0.015538364,0.015522299,-0.077134624,0.09040957,-0.002204131,0.053831577,-0.059753507,-0.019200016,-0.031633213,0.12505537,-0.06322346,-0.041858137,0.059791632,-0.00957454,0.015350042,0.069035314,0.032169633,-0.012533707,0.05790968,0.044011153,-0.0422627,-0.08921169,0.021433532,0.0326468,-0.10126502,-0.013592533,-0.033577263,0.0207022,-0.0146513805,0.08516037,0.060139533,0.026071884,0.035599485,-0.03416209,3.947126e-33,0.031495973,0.0015445685,0.046924915,0.06634316,0.041035455,-0.004792226,0.036637682,0.005417627,-0.009533404,-0.0091043925,-0.0724252,-0.047081806,0.007945018,0.07666311,-0.027140968,0.017110126,-0.011919179,-0.07528208,-0.019584674,0.009990833,-0.014157807,0.05642946,0.026024383,-0.029149432,0.03995474,0.02993707,-0.046165057,-0.003111108,0.024510672,-0.006122455,0.07934858,-0.057616368,-0.086651,0.060468134,0.07042843,0.069581725,-0.043882307,-0.02642544,0.025314728,0.029146979,0.024860531,0.018797899,-0.052196663,-0.080449365,0.03312288,-0.038141113,0.00697194,-0.021019282,-0.05263246,0.06369803,0.06254613,-0.017205022,-0.0018817082,0.023356412,-0.121555746,0.009244424,-0.035413906,-0.06296367,-0.0036242267,0.09706927,0.017871622,-0.009514857,-0.035639368,-0.020388065,0.028566876,0.020145236,-0.08203925,-0.018205337,-0.041225296,-0.012246336,-0.04165117,-0.104908034,0.07470122,0.028264042,-0.004792812,-0.025341162,-0.061297495,0.065119,-0.030281447,-0.0113577265,0.048321396,-0.018527111,0.004371903,0.019657675,-0.12608978,0.02309695,0.052893966,-0.073708944,-0.06604673,0.042558163,0.03011106,-0.09246732,-0.03671419,0.093481645,-0.025339909,-6.753462e-33,0.09736752,-0.10059408,0.11800673,-0.048900984,-0.04922454,0.022182478,0.06843766,0.01577372,0.0020354998,-0.07145518,0.08062329,0.010492725,0.016703257,0.017696196,0.03046592,-0.03562807,-0.07872309,0.15196995,-0.02229439,-0.005655042,0.015703976,-0.0035726659,0.00048613915,-0.031723775,0.068902165,0.0403565,0.026052076,0.02281369,-0.012288476,0.05601983,-0.03331679,0.049245562,-0.0628336,-0.08106542,-0.031567972,-0.06695643,-0.0808482,-0.0730785,-0.010751719,-0.06410586,0.004270791,0.04360794,0.08058144,-0.008938403,0.030598473,0.069499455,-0.06657352,-0.037496913,-0.012990043,-0.011451487,-0.024256598,-0.016889524,-0.04018252,0.02258208,0.0077601722,0.09295101,0.028897345,0.01647314,0.039647255,-0.04261566,-0.060077135,0.049969587,0.02776872,-0.01121701,0.068635195,0.020438429,-0.0087622935,-0.044817843,0.06524885,-0.014254684,-0.050021786,-0.023953186,-0.032362748,-0.02214851,-0.01879431,-0.042527564,-0.14549907,-0.029961888,-0.005173577,-0.041911356,-0.012083609,-0.05941844,0.023481,-0.005698357,0.061278418,-0.040473703,0.059650354,0.13076524,-0.00458741,0.03487507,-0.0077279094,-0.015095362,-0.049224816,0.07854833,0.11630176,-5.0252495e-08,0.027800616,0.0054673115,-0.08144816,-0.07073944,-0.03459815,-0.031645678,0.009207676,0.04827967,-0.006197775,-0.01216774,0.028548248,0.090962045,-0.05821836,-0.03426393,-0.057550106,0.06363325,-0.08576632,-0.048083857,0.023691088,0.014721479,-0.14545007,-0.012967813,-0.034796815,0.045287374,-0.021366037,-0.048784576,0.023626601,0.11982799,-0.011221485,-0.052251972,0.0035483816,0.038466945,-0.028286677,-0.10683154,0.005877422,0.026380809,-0.035845395,-0.018344648,0.0686966,-0.0069226124,0.009291542,0.038181666,0.020253757,-0.0111633595,0.027410917,0.02818385,-0.04534141,0.063803114,-0.028134571,0.048995826,-0.026958497,-0.0023550005,-0.071830295,-0.052736007,-0.0885933,-0.07700815,-0.05516677,-0.021726053,0.023632035,-0.036768883,-0.012546903,-0.03296976,0.10667938,-0.03473973 +2.4.99.19,"A bacterial enzyme that has been isolated from Campylobacter jejuni [1] and Campylobacter lari [2]. It forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chains. Requires Mn2+ or Mg2+. Occurs on the external face of the plasma membrane. The polyprenol involved is normally tritrans,heptacis-undecaprenol but a decaprenol is used by some species.",384,1.0,-0.05441204,-0.109987676,-0.1178663,-0.014399434,0.03722393,0.033888657,0.03456644,0.060906004,0.07564626,0.037001118,0.057753228,-0.04070415,-0.008806571,0.10924139,-0.038341966,-0.025241015,-0.009159694,-0.026634626,-0.004298282,0.02882871,0.048572227,0.016130025,-0.03265134,-0.03866961,0.024588728,0.00800585,0.059895262,-0.09814739,-0.009976193,-0.057162233,-0.027005902,-0.0666625,0.03364929,-0.05243245,0.12952052,0.06621468,-0.06286329,-0.040862456,0.09899121,0.002592955,0.047894377,-0.001034987,0.052583594,-0.081772745,-0.0059360145,0.0041639903,0.0062942193,0.028676523,0.05047747,-0.011488348,-0.025446096,-0.06667456,-0.03579799,0.070409596,-0.005588576,0.005018791,-0.06325378,-0.06820578,0.0016978033,0.048768457,-0.03379531,0.087542705,0.07507901,-0.027032612,-0.04784369,-0.06044121,0.029791534,-0.019882515,0.009968445,0.025045767,-0.04440434,0.016504616,0.009952538,0.029290428,0.024084529,-0.01820779,0.014953069,0.017577132,0.0384065,-0.02783596,0.023442382,0.03395764,0.08928568,0.059921034,-0.06712797,-0.028111657,0.04543779,0.05012581,0.085550725,0.059937183,-0.007082571,-0.00021512315,0.022442896,-0.052573442,-0.029667662,-0.10905006,0.04593303,0.02259101,0.04062507,-0.015383168,-0.03464831,-0.0500069,0.07766992,-0.09707077,-0.06534407,-0.027491583,0.06679082,0.043526433,0.07356409,0.025248595,-0.03465202,0.07846801,0.008305023,-0.05676568,-0.07003875,0.039413046,0.069798395,-0.08052034,-0.04645458,0.03118478,0.0324548,-0.07515479,0.104676515,0.0467575,-0.0052116145,0.057889927,-0.07404671,6.795259e-33,0.020659193,0.016849002,0.08193543,-0.03727825,0.019485489,-0.032874748,-0.03873349,-0.07205264,0.00013010735,0.0003524926,-0.10069655,-0.073553845,0.0045887376,0.06156258,0.03190279,0.011886581,-0.066758536,-0.050508805,0.037264165,-0.01691126,-0.0087499805,0.07188509,0.020166636,-0.028853588,0.058447152,0.0024913435,0.0061499863,-0.032967027,0.02418122,0.004979327,0.07316006,-0.099267036,-0.081619166,0.07065121,0.10775237,0.023105675,-0.042998374,-0.06770933,0.0029195072,-0.024442604,-0.041365605,0.039244793,-0.049763434,0.00209058,0.033724554,-0.08393253,-0.046401102,0.06179124,0.01877222,0.032492995,0.028011708,-0.0019031041,0.011521723,0.0031704756,-0.089921705,0.022190556,-0.0279794,0.006179559,0.03375815,0.09661752,0.08233935,0.077662505,-0.0433261,-0.03021855,0.037178062,-0.0057697715,-0.011108183,-0.02684008,0.029617438,-0.057488337,-0.044191282,-0.13531667,0.058262974,0.056850597,-0.0045353887,-0.054402467,-0.030621111,0.047211703,0.057984732,-0.0535344,0.0012094297,-0.03056164,0.051411856,-0.03504646,-0.117242225,0.022586383,0.002731349,-0.064246126,-0.06871245,0.044426125,0.07553984,-0.0011157884,-0.06343109,0.016011138,-0.011689322,-8.174549e-33,0.045615967,-0.09854662,0.05878291,-0.025648037,-0.048444908,-0.012983588,0.026923142,-0.06390854,0.014626804,-0.033207055,0.03419663,0.060446393,0.059948396,-0.007503198,0.05393277,0.005805635,0.016504245,0.07781039,-0.04909992,-0.06775926,0.041184954,-0.009394593,0.024196327,-0.07734383,0.012051106,0.018234195,0.01846909,0.10690751,0.00926406,0.033342727,0.0073329355,0.059936166,-0.050002083,-0.1277176,-0.031384967,-0.07855255,-0.070109606,-0.08493757,-0.024862954,-0.086509116,0.039197523,0.0065525523,0.05796112,0.032906797,0.01183481,0.048754577,-0.0750323,-0.026992802,0.031655133,-0.04529527,-0.04897769,-0.026074558,-0.03412401,-0.0029520304,-0.014048637,0.07178162,0.021524856,0.025298212,0.002614705,-0.018187093,0.03184164,-0.031876724,0.051035937,-0.011500761,0.09590381,-0.005471022,0.07209412,-0.01732237,0.06258907,-0.06850709,0.06571947,0.0024557665,-0.05002025,0.018455027,-0.06863792,-0.004845076,-0.08438044,-0.020526262,0.01316056,-0.07594945,0.066481985,-0.041283786,-0.008152638,-0.043753833,0.07848118,-0.043803908,0.07680713,0.14650969,-0.017791808,0.029475035,0.0013395925,-0.055919066,-0.035920665,0.07778783,0.058044467,-5.9083458e-08,-0.01685309,-0.053267997,-0.023059733,-0.06567548,-0.032861553,0.024713688,-0.037289284,-0.06712302,0.012008143,-0.013785059,0.026574511,0.09455555,-0.044433977,0.0017507689,0.0066051343,0.04795129,-0.058036096,0.040666487,-0.017338887,0.012218149,-0.097411886,-0.006264568,-0.09893739,0.010222682,-0.033941444,-0.04278888,0.026750986,0.12739135,-0.009170594,-0.047280062,-0.006110095,0.060276955,-0.00054229284,-0.089757,-0.066361785,0.0746868,-0.057904135,-0.041396406,0.007382523,0.031885225,-0.0012490673,0.024457777,0.00069686776,0.010487779,0.0015482851,0.029255955,-0.029691305,0.029850932,-0.08050246,-0.018784074,0.046873145,-0.027618816,-0.05462667,-0.014078684,-0.05901712,0.02857194,-0.03279026,-0.037496626,0.02921221,-0.007539558,-0.018669851,-0.017287666,0.09510556,0.018866103 +2.5.1.99," Requires Mn2+ for activity. The enzyme from the bacterium Pantoea agglomerans (previously known as Erwinia herbicola) produces the all-trans isomer of phytoene. cf. EC 2.5.1.32, 15-cis-phytoene synthase.",384,1.0,-0.06076458,-0.057844598,-0.070609555,0.028813131,0.06660201,0.057374638,-0.023758192,0.016543988,0.02118084,-0.013021674,0.02130736,-0.06972837,-0.019911451,-0.0027390367,-0.010691851,0.050093956,-0.07668275,0.0781485,-0.04102822,-0.060595013,0.05728571,0.04319196,0.007971989,-0.045373764,0.07663641,-0.0034874198,0.0022926324,-0.07800786,0.009437683,-0.025618112,-0.019150712,-0.013887363,0.103912316,-0.06751238,0.032733805,0.039913964,-0.012112703,-0.08342775,0.08191563,0.008626354,0.037810568,0.01584506,0.06080472,-0.04917941,-0.07035583,0.019301329,0.07864054,-0.055613145,0.0024192885,-0.03766646,-0.11300896,-0.05814002,-0.0790143,0.00993783,0.0011477831,0.030000972,-0.011654183,0.0018978482,-0.012041971,0.011370301,0.022237923,-0.03405472,0.022334589,-0.00975769,-0.021635033,-0.036290336,-0.02826611,-0.05154115,0.025097333,-0.030297762,-0.06924304,-0.050771695,-0.07729323,0.084388666,-0.00883587,0.031867683,-0.01466182,0.057463676,0.013158459,0.0025184746,-0.05606225,0.02206012,0.048615582,0.026919201,0.046521936,0.08559988,0.04471744,0.105565175,0.0112991445,0.00522617,0.028751802,0.017711194,0.014798503,0.008383838,0.01061824,0.023057288,0.022317095,0.0054430435,0.04943657,-0.0027170358,0.025644884,0.0290643,-0.069792494,-0.068540715,-0.043323185,-0.02305691,0.02782084,0.0645823,-0.021190379,0.07195984,0.10104697,0.00660624,0.010771608,-0.04257477,0.007403489,0.058241878,0.045422956,-0.07512982,-0.014685078,0.0015332263,0.03362319,-0.056051455,0.0009498427,0.1312304,-0.058831066,0.06372884,-0.054283172,2.1245472e-33,0.049265563,0.08803754,0.03587389,0.025918394,-0.04034817,0.015407286,-0.051505696,-0.0078582205,0.0837916,-0.10213852,-0.1533504,-0.056467198,0.01868417,0.051805865,-0.06820885,-0.054704286,0.011254315,-0.055215023,0.1368493,0.005884072,0.01751865,0.0013006774,-0.0785994,0.07696852,-0.029724892,0.053829852,0.054088272,-0.045641806,0.08484258,-0.034087572,0.017095871,-0.13597082,-0.054663975,0.0103680575,-0.0049563986,0.0018304602,-0.07841925,-0.03761306,-0.029544318,0.08064053,-0.0023046075,0.057104073,-0.033704743,0.06513564,0.11312044,-0.008879632,-0.0645464,0.0677274,-0.002254954,-0.0016490145,-0.08123835,0.041704975,0.061126925,0.0054999683,-0.060444895,0.0075743296,0.0602911,0.025231497,0.04629182,0.0645745,-0.04060512,0.09618955,0.050846394,0.066333205,0.012331029,0.09095732,-0.065726325,-0.05236792,-0.019371137,0.06454604,-0.02293993,-0.08936355,0.030333072,0.023401538,0.015360949,-0.07875961,-0.10411586,-0.09814538,0.022983382,-0.010170252,-0.036577675,0.026265811,0.013850472,-0.02268495,-0.09436597,-0.06059831,-0.09764487,-0.013808947,0.0024114682,0.061276156,0.08483845,-0.02816371,-0.07210373,0.06394788,-0.022263488,-1.6225762e-33,0.03641432,-0.025410088,-0.0039930567,-0.021117883,-0.09613169,-0.014633259,-0.031196872,-0.08811374,0.0272226,0.053282678,0.091621414,-0.029812604,0.0476135,-0.016910836,-0.039012205,-0.0385653,0.046388924,0.10954604,0.02522074,0.0530514,-0.07691754,0.07014628,0.005314323,0.0016108361,0.03478049,0.08172052,-0.0053815157,0.085539415,0.007719959,0.023010114,0.020569481,-0.040951904,-0.057239242,-0.07415169,-0.010579403,0.01424159,-0.0035759304,0.008572173,-0.0010174832,0.025029127,0.017484793,-0.043505263,0.0051812003,0.12912816,-0.02115452,-0.037920658,-0.06969615,0.03553246,-0.018443123,-0.033337798,-0.009315265,0.06063885,-0.0442338,-0.07118442,0.0350577,0.02613911,0.016320774,0.039696988,-0.013196029,-0.039321627,-0.03867014,-0.07731638,0.06941985,0.0013811749,0.03865072,0.11536665,-0.024251547,0.15832156,-0.0379138,0.031782646,0.026088146,0.021849308,0.038611714,-0.0025317357,-0.054801073,-0.014712337,-0.025680954,0.0027660464,0.0067278123,-0.013359143,-0.0157707,-0.060119286,0.026009431,-0.097178966,-0.015634453,-0.03284436,0.035126336,0.06670454,-0.025644135,0.05921324,0.002518485,-0.09934486,-0.046620544,0.06181753,0.045710325,-3.450342e-08,-0.011400326,-0.044588827,0.03588163,-0.026722092,-0.017764103,0.03599514,-0.023750544,-0.01258591,0.041183725,0.0045955162,-0.073544316,0.021501452,0.009910217,0.022615619,0.08312165,0.074966066,-0.008097381,0.01633634,-0.012357061,-0.0007014628,-0.047129843,-0.040880445,-0.114577785,0.03304234,-0.004043847,-0.03828365,-0.00026574003,0.03843165,0.073964186,-0.03748008,0.00974187,0.0034904787,-0.0016814221,0.038090844,-0.07948075,0.044146527,-0.0009643349,-0.049545374,-0.014207465,-0.011582608,-0.057840608,-0.00811992,-0.065293595,0.01933621,0.017143326,0.012563392,-0.014509757,-0.0055362014,-0.02803012,-0.029518517,0.037375808,-0.039582625,0.058969397,-0.0076973992,-0.051193405,0.040923953,-0.005240918,-0.019750832,-0.04861643,0.022951655,-0.030120462,0.015617612,0.15987296,-0.027905537 +2.5.1.100,Fumigaclavine C is an ergot alkaloid produced by some fungi of the Trichocomaceae family. Activity does not require any metal ions.,384,0.99999994,-0.02863462,0.03292028,-0.16513686,0.034559987,-0.030736873,-0.03196318,-0.022896519,0.047236525,0.040440675,-0.024863318,0.053779308,-0.19307676,-0.06523461,0.0038336054,-0.10342298,-0.02281853,-0.016754605,0.03417445,-0.024912285,-0.0008551729,-0.04340371,0.020695591,0.09491508,0.02501485,-0.065897845,-0.003451325,-0.12011834,0.0627939,-0.012222193,-0.082568236,-0.008530836,0.07908671,0.07272772,0.016483556,0.016591355,0.031276774,-0.116611294,-0.03299324,0.080327936,-0.022431655,-0.08495093,0.0076877703,0.0191531,0.030067677,-0.0330314,0.017598664,-0.012410003,0.06585947,0.03937864,0.099412665,0.011588905,0.033124514,-0.0609017,0.027571246,0.023611862,-0.026511686,-0.01852746,-0.012788722,-0.026688492,0.09774697,0.11776551,0.06502919,-0.09667456,0.012239028,-0.10596389,-0.018772513,0.019279502,-0.083556324,0.037606977,-0.0322476,0.04504861,-0.053086407,0.022914536,0.0013186013,0.039358985,0.15793371,0.07773789,-0.06325618,-0.025651824,-0.037812904,0.08985815,0.057174597,0.07410908,0.041210674,0.023892934,-0.027156811,-0.034260176,0.010744216,0.0117587345,0.043407857,0.13174967,0.07475894,0.03868037,-0.041133165,-0.016783921,0.085829854,-0.010824401,0.04959475,-0.03255705,0.020667925,-0.02186049,-0.042281613,0.027311541,-0.019956099,0.010240145,-0.023403028,-0.008908701,0.016825767,0.011748904,-0.055613913,-0.040552866,0.019014983,0.0029782644,-0.07294899,-0.04445577,0.104521975,0.09520919,-0.027007692,-0.02482382,0.058994394,-0.02669712,-0.013744328,0.0047766333,0.022430353,0.027224151,-0.11568599,-0.027959041,2.6043592e-33,0.0041847993,0.046377443,-0.0064809024,0.0050910474,-0.0010524787,-0.039318644,0.06048385,-0.10802667,-0.07853464,-0.02443366,-0.086025886,0.03662868,-0.012346948,0.07307653,-0.029393611,0.02993659,-0.015078961,-0.07054542,0.04186572,-0.058036625,0.0144928405,0.00526031,-0.01440135,-0.07982406,0.027338736,0.06272771,-0.016050277,0.05954093,0.008315346,-0.009122289,-0.019290471,-0.035884757,-0.021960765,0.0064170333,0.053658467,0.08321774,-0.071145624,-0.046602733,-0.031996913,0.021666601,-0.010796226,0.071278356,-0.060184203,-0.0012623906,0.041796338,-0.005197578,-0.06582007,0.09918351,0.026489595,0.04833781,0.042675506,-0.015531512,0.05755917,0.02293393,-0.06532487,0.018782953,0.037262198,0.029405516,0.021034641,0.071346186,-0.05409172,0.06281133,-0.0039091236,0.051014893,0.03209815,-0.03755385,-0.06796847,-0.08088141,0.044553835,0.0112359915,0.013999571,-0.04512617,0.04503271,-0.02728584,0.012522388,0.046533152,-0.10744276,-0.0727708,-0.04590229,-0.031698316,0.010468127,-0.080586396,0.048823148,-0.024820952,-0.086481005,0.004592408,-0.07272855,-0.009171544,0.0060326396,0.027328806,-0.03645797,-0.009756654,-0.016037393,-0.02293121,0.042245913,-3.3164736e-33,0.0027800074,0.0031031084,-0.011384559,0.021802077,-0.018789342,0.041174658,-0.09295576,-0.06547253,-0.029844258,0.067227945,0.09475711,-0.031234626,0.041172735,-0.011051147,-0.03189892,-0.003573065,0.0882969,0.07329059,-0.009901053,0.070195496,-0.07129532,0.028313585,-0.050225288,0.03947979,-0.0043512215,0.030479103,0.036309473,-0.07312107,-0.027664836,0.030283548,-0.06377251,0.039569974,0.02264725,-0.06840717,0.06417502,-0.044593975,0.05485766,-0.047523323,0.015593,0.0016333044,0.01752296,0.082594864,0.06549541,0.058757715,0.05202378,0.0335059,0.002966369,0.021276662,-0.0038692763,0.0083438875,0.051327415,-0.033032767,-0.022440223,0.014055214,0.0328276,0.034962907,0.053925507,-0.06486773,-0.039445445,0.013627945,-0.030038586,-0.07993654,-0.02020534,-0.11026269,0.04819392,0.0917905,-0.0072092223,0.06302323,0.07371308,-0.02251932,0.055599477,0.049463883,-0.020819353,-0.039925776,-0.15259796,-0.016669992,0.050305117,-0.028353263,0.042986535,0.0020146128,0.07096996,-0.008236536,0.07053284,-0.0140651325,0.037763417,-0.0865447,0.0019933735,0.03752141,-0.05674639,0.03798148,-7.61411e-05,0.0043517123,-0.036578227,0.026014734,0.037764985,-3.0808994e-08,0.057379168,-0.02679415,-0.051506754,0.010977597,0.002922155,0.015887411,0.03301787,-0.05251278,-0.03573433,0.026059581,-0.02503794,0.08311011,-0.0162695,0.040252198,0.050134808,0.024519175,0.010771937,0.039188445,-0.0077482197,0.01018931,-0.009850799,0.030583713,-0.014226481,-0.044883095,-0.035749987,-0.045233175,-0.0036424422,-0.029362323,0.059183054,0.01219661,0.019599015,0.017761862,-0.053474393,-0.032136068,-0.032077283,-0.04354291,0.008161585,-0.09122972,-0.084202945,-0.00064374076,-0.017016536,0.07275526,-0.032316517,0.010210656,-0.09402475,-0.059914466,-0.01911255,0.045976844,0.019527929,0.007625825,0.048451617,-0.016771777,-0.013539618,-0.014333871,-0.087364264,0.006716715,0.010791111,0.03245471,-0.0118978815,-0.08827669,-0.012898857,-0.0683454,0.1266239,-0.01965838 +2.5.1.101,"Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.",384,1.0,-0.048478883,0.0018470655,-0.036580823,0.01644414,0.082264304,0.036545925,0.018685177,0.032117903,0.04126467,0.004905067,0.038655993,-0.092277594,0.07319064,0.058965668,0.04514539,-0.040931106,-0.036545325,-0.010135376,-0.047503073,0.0503577,0.047945928,0.0987797,-0.0010008491,-0.08880054,-0.010477136,0.0928094,0.07753061,-0.016969765,0.012817305,-0.013846315,-0.03515589,0.020587485,0.0049802475,-0.13050124,0.08565104,0.033676762,-0.04374984,-0.0075549986,0.06639726,-0.022165094,0.03066582,0.0026932228,0.09891927,-0.07711015,-0.002293641,0.0036857352,0.09939149,-0.021216625,0.048184104,0.0042226817,-0.020003887,-0.009132901,0.035771914,0.08383382,-0.011797224,0.018464046,-0.062245265,-0.014745393,-0.0115272105,-0.0054688505,0.011714144,0.02772004,0.07106024,-0.01835013,-0.019889116,-0.058459163,0.043235052,-0.004621018,0.07767358,-0.015256909,0.032012433,0.013602177,-0.038613718,0.031689305,-0.014647648,0.083481476,0.15147315,-0.054379266,0.08977319,-0.025476335,-0.07332921,0.021996846,0.121708795,0.066162094,0.022373594,0.049894072,0.036768366,0.08232862,0.030955957,0.043484893,-0.008195419,0.033982795,-0.016101597,-0.039293133,-0.06834653,0.0031227905,-0.014249232,-0.0014370967,-0.007906219,0.04061185,-0.0071590473,0.0038627936,-0.039608505,-0.034313995,-0.007644215,-0.0473455,0.034420803,0.07612083,0.003024005,-0.0016487013,0.0425056,0.02014669,-0.011952303,-0.05155709,-0.0013575159,0.0015931401,0.103345774,-0.08456003,-0.06956779,0.020568242,0.0787485,-0.08278638,-0.048753656,0.031510293,-0.0067175278,0.05328224,-0.08400832,2.723036e-33,0.013562066,0.0008687987,0.035269033,-0.021025425,0.010951301,-0.016729828,-0.03723629,-0.11113544,-0.036655027,-0.0922435,-0.09237407,-0.06859505,0.015664874,0.04166304,0.00523538,-0.034275535,-0.04399022,-0.057673436,0.10960456,-0.060410496,-0.0046573537,0.073531985,0.027543848,-0.013941363,0.023072923,0.01917801,0.05833775,-0.03219332,0.04295022,0.011158126,0.01921161,-0.08141227,-0.035025712,-0.01335057,0.082036346,0.03746385,-0.13331209,-0.028024705,-0.040116288,-0.042726114,-0.030475406,0.117364794,-0.097831376,0.06485732,0.053314444,-0.06786014,-0.055414896,0.03255682,0.016705036,-0.047071654,0.013011933,0.08507087,0.037044544,-0.04337467,-0.0463968,0.007623376,0.036801465,0.018138282,0.011978547,0.02445385,0.010699882,0.049235802,-0.031992413,0.14021853,0.07661388,-0.0056594545,-0.004747027,-0.03567435,-0.0018869062,-0.042461038,-0.023304552,-0.0583448,-0.00016402527,0.019786691,-0.0896615,-0.014912494,-0.0108599095,-0.07036441,0.06365769,-0.038913317,-0.057052925,-0.03309722,0.0006726531,0.01823213,-0.12128488,-0.031333245,-0.016267192,-0.012913217,0.010953901,-0.056299265,0.0732791,-0.0134303095,-0.046890482,0.0056269234,-0.07299048,-3.469712e-33,0.0057643563,0.021279348,0.032415256,-0.091494314,-0.0568331,0.02305974,-0.028378049,-0.07341347,0.00192616,0.02404996,0.02947575,0.0350154,-0.0095728785,-0.052911807,0.017041195,0.005596122,0.07645713,0.10597536,0.03302719,-0.042341787,0.043593954,0.06269696,-0.039953012,-0.018371671,-0.031098846,0.023754269,-0.048652526,0.041820485,-0.04795992,0.011549589,-0.00232859,0.013311439,-0.018928768,-0.13693273,0.01054388,-0.062132746,0.0379846,-0.049890313,0.067487754,-0.030845234,0.02514939,0.013632639,-0.002546575,0.1277896,-0.01262161,0.022251809,-0.034803383,-0.022380447,-0.028384121,0.006476106,-0.05207036,-0.075401515,-0.03324892,-0.087773085,0.016024817,-0.04551263,0.007213358,0.0090217,0.013667736,-0.019499106,-0.00028437757,-0.018918272,0.010061062,-0.011867245,0.014276194,0.09041305,0.081817895,0.04054784,0.011958971,-0.04984667,0.05523941,0.08853164,0.036603797,0.02077589,-0.023928687,-0.080348134,-0.054360572,-0.014484242,0.04233617,0.015915599,0.04696043,-0.021945765,-0.02120451,-0.02965195,0.06857667,-0.07995349,0.06811575,0.10537746,-0.0024564455,-0.013049613,-0.032626066,-0.09458315,-0.007531159,0.09519109,0.014098981,-3.7046398e-08,-0.010509999,-0.06796833,-0.03639097,-0.09396975,-0.09302339,0.04201807,-0.020341085,-0.04377031,0.10240815,-0.006385074,0.026412424,0.041750763,0.022690944,-0.039548915,0.015157231,0.074718975,-0.023219109,-0.033038326,-0.073760584,-0.07916176,-0.034158166,0.025515711,-0.030858185,0.035931464,0.031542316,0.0044994797,-0.050672244,-0.017329622,-0.06391353,-0.024058413,-0.0045839017,0.031235406,-0.03416012,-0.033716034,-0.10217504,0.07111952,-0.00057980925,-0.05562916,0.0139172515,0.012027388,-0.03938498,0.026454387,-0.022212038,0.028432565,0.04185903,0.025793254,-0.062924266,0.042149756,-0.06175655,-0.12990019,0.038633488,-0.061192315,-0.016705759,-0.002213176,-0.11837588,0.060017645,0.020031994,-0.008249072,0.005427302,-0.041489866,0.010714368,0.0084704375,0.114566565,-0.03227997 +2.5.1.102,"Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.",384,0.99999994,0.010652004,0.059357274,-0.09190315,-0.02680273,-0.022172634,0.06544528,-0.037815455,-0.014966371,-0.004325048,0.0059393304,-0.011704706,0.015536338,-0.050062906,0.0019828829,-0.04926582,0.019607851,-0.0031946406,0.027469035,-0.028384808,-0.016933925,0.05968688,0.11348355,0.015822181,0.013175536,0.01995333,0.00089979294,-0.02799877,-0.0013997274,0.0723453,-0.07677911,-0.014326045,0.04211217,-0.0337108,0.011289407,0.007984834,0.021475902,-0.0608549,0.02005038,0.06887599,0.012701268,0.11891536,0.01684348,-0.08538095,0.031401634,-0.073481806,0.005678254,0.009193763,0.007814233,0.026661485,-0.03897975,0.0016614364,-0.06217584,0.03811605,0.013672488,0.038491458,-0.004353641,-0.011011163,0.10387364,-0.0022231846,0.08795906,0.064590685,0.014000269,-0.058764767,-0.038391937,0.052863292,-0.030454371,-0.06330717,-0.021120949,0.06364557,-0.105170354,0.019860761,-0.10765176,0.0077034584,-0.033976074,-0.0647394,0.037935406,0.045213293,0.032734584,0.0074749542,-0.07870457,0.03455878,0.06619887,-0.016242726,0.04449187,0.04152753,-0.023032755,-0.021959499,0.0523695,0.02526621,-0.012413509,0.05688749,-0.005984567,-0.068222746,-0.06499057,-0.024948524,0.010471914,0.08441521,-0.054322995,-0.01516321,-0.026406923,0.051575694,0.06691273,-0.050053433,-0.104374826,-0.060124364,0.031178774,-0.00051369966,-0.07171199,-0.011290788,0.004332954,-0.023281861,-0.02259337,0.05085068,0.03774969,-0.05959252,-0.0005926243,-0.029096851,-0.0016135899,-0.010706599,-0.07290741,-0.055629473,-0.0062234127,0.01631149,0.0810685,-0.018504689,-0.017848067,-0.0871248,2.542874e-33,-0.00191728,0.05818049,-0.025355427,0.012468966,0.029261688,-0.0396904,-0.0028979157,0.009422865,-0.024899954,-0.053903874,0.01061934,-0.09203899,-0.04364823,-0.0037567872,-0.0035474529,-0.07563925,-0.05550677,0.012112562,0.08253126,-0.022141173,-0.115353,0.058761977,-0.16992149,0.01977687,-0.04803973,0.011196849,0.02305189,-0.037365347,0.04524,-0.025986183,0.0044120457,0.020902932,-0.092274696,0.029168254,-0.009411244,-0.016765406,0.081026725,0.002189331,-0.06697438,0.016344424,0.041467827,0.042420764,0.06258706,-0.0147506455,-0.030557927,0.008439125,-0.110907495,0.055303726,0.09425949,0.07866305,0.011368612,-0.0004587314,0.14393519,-0.05309182,-0.047193374,0.01105414,-0.053296287,0.029994385,0.05230325,0.01639506,-0.061044488,-0.011385023,-0.08042557,0.05254075,0.036495194,-0.007482128,-0.10921223,-0.073768705,0.061749566,0.049903702,-0.08890432,0.039956454,0.02620184,0.043725833,-0.06140171,0.0059974706,-0.05767181,0.048850678,-0.018339131,0.031232547,0.03484908,-0.06620832,-0.07755018,-0.021297274,-0.0157797,-0.025202842,0.054997653,-0.021432005,-0.04912083,-0.042064168,0.0060346904,-0.037451066,-0.039445978,0.018740922,0.07466092,-3.4154374e-33,0.13408211,-0.08024807,0.080678694,-0.05352343,0.003888829,0.04319634,0.0019887045,-0.051659375,0.018717527,0.026594082,0.032278884,-0.021223124,0.12194024,0.011176195,-0.033146672,-0.022580383,-0.027763398,0.09158965,-0.047170714,0.040544312,-0.07737974,0.069176786,-0.022819139,0.030509843,-0.018370923,0.027574163,-0.030245636,0.09377719,-0.020380601,0.08887253,0.06786188,0.07077447,-0.09043056,-0.044000503,-0.081899606,0.03934557,-0.005895433,-0.0067369975,-0.03422293,-0.024363518,0.033990785,0.080528125,0.049445853,0.07067013,0.0355458,0.036332272,0.0072964774,0.051091686,-0.021764575,-0.0014640231,0.049270954,0.016114654,-0.029602116,0.06584053,0.0743472,-0.030375717,0.021373827,-0.06632748,-0.0016802028,-0.10247243,-0.011922793,0.049788512,-0.032060213,-0.10240774,-0.006591289,-0.006623825,-0.0095961215,0.04060415,0.040000666,0.038135953,0.06932105,0.03237755,0.13663526,0.0901632,-0.0461205,0.040259264,0.060884222,-0.0522347,-0.021607134,-0.07816623,0.010390109,-0.0074654664,-0.031480163,-0.025193445,0.08639004,0.048256822,-0.011510695,0.09287912,0.02733847,0.0002820252,-0.056128565,-0.0061884103,-0.08070063,0.0925697,0.026627809,-2.9050604e-08,0.012526975,-0.06110529,0.013648103,-0.06635708,-0.03955251,0.05361565,0.0415831,0.036951225,0.044582494,-0.062934585,-0.03535105,0.012008103,-0.047793604,0.036453176,0.04930408,0.018187886,-0.001728174,0.07243347,-0.016148712,-0.03276184,-0.090155095,-0.06294396,-0.022545585,0.02325502,-0.02067825,-0.0035151143,0.009438757,0.009933195,0.032330435,-0.004584142,0.06432429,0.00232363,0.03501885,-0.0072610388,-0.002983758,0.04114272,0.032957535,0.030553235,0.01669035,-0.040519495,0.00092438905,-0.08338079,-0.06878829,0.0012089188,-0.063191265,-0.06453641,0.0025138601,0.07262167,-0.019499773,0.030140128,-0.041287422,-0.0011016378,0.056551423,-0.08220703,-0.088127956,-0.054071464,-0.009682686,0.022049354,-0.014849988,-0.037435915,-0.015500411,0.08527402,0.16505584,-0.0036468392 +2.5.1.103,"Isolated from the green alga Botryococcus braunii BOT22. Unlike EC 2.5.1.21, squalene synthase, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme. This compound is then converted into either squalene (by EC 1.3.1.96, Botryococcus squalene synthase) or botryococcene (EC 1.3.1.97, botryococcene synthase). ",384,1.0,-0.07577826,-0.06393113,-0.042115662,-0.010947862,0.006016679,0.039600804,-0.109009355,0.0061712274,0.009240302,0.058829647,0.07475466,-0.14597057,-0.055100195,-0.014515317,-0.042472485,0.003337224,-0.023339761,-0.049745888,0.048228037,-0.0012673383,0.15425603,0.06490476,-0.0009798472,-0.02827217,0.054306366,-0.01694895,-0.015142486,0.011074778,0.07123179,-0.09323502,0.05563287,-0.0007825064,0.0032115302,-0.052960243,0.06023694,0.050433084,0.008835231,-0.07103787,0.1296871,0.10243217,0.012921605,-0.011619853,0.033156168,0.0065346234,0.05287705,0.022948537,-0.018227316,0.13901463,0.021459619,-0.093845375,-0.046107456,-0.056840364,0.00800706,-0.030175248,-0.038460072,-0.04928683,0.0702484,-0.009252634,0.055380322,0.004844199,0.10015354,0.005726266,0.07699562,-0.02725666,-0.07615113,-0.01257838,-0.0098865265,-0.0690097,0.05751395,-0.01808119,-0.13159682,-0.044482093,-0.016269617,0.04942596,0.083786145,0.070756555,0.015591564,-0.109735094,-0.005702787,0.03990445,0.0028539775,-0.039077394,-0.020977966,0.0324377,-0.01776848,-0.045769986,0.079024926,0.031882863,-0.019482614,0.015488609,-0.02277673,0.004711773,0.027282726,-0.0385511,-0.076630056,0.046851575,-0.016689027,0.108409725,0.039453145,-0.022302508,0.045512922,-0.09834109,-0.019135118,-0.12715593,-0.026001208,-0.009384471,0.049682204,0.039226387,0.04379787,-0.010139421,-0.06881547,0.053574838,-0.037730496,-0.016641533,-0.029641755,0.05096039,0.039034456,-0.057123024,0.02769834,0.017151302,0.010439226,0.02581951,-0.0016849346,0.07702379,-0.0047043455,-0.05430939,-0.09456186,5.1753284e-33,0.017782636,0.0022568433,0.021738958,-0.064472824,-0.028154746,0.029173415,-0.080274105,-0.04077591,-0.049639016,-0.06480791,-0.036250792,-0.010423756,0.006397984,0.023313986,-0.061970603,-0.08763408,0.029558944,0.010381035,0.07119925,-0.08100292,0.021362804,0.022694822,-0.061330058,0.0363769,0.10515815,0.064767964,0.052150037,-0.08121664,0.018012866,-0.044627134,0.036865685,-0.06393811,-0.060374428,-0.01460751,-0.001930861,-0.08088954,-0.030254023,-0.05274313,-0.03987562,-0.04301049,0.016691756,0.078400105,0.046546593,-0.018999502,0.083084926,-0.015586866,-0.07235224,0.070226744,0.11855247,-0.03519048,-0.046434067,0.0052898005,0.10006327,0.02226429,-0.008469381,-0.0074644703,-0.036185615,-0.039514046,0.045908485,0.02238602,0.028040867,0.12307588,-0.033315543,-0.0005763428,-0.026400719,-0.00756607,0.00028629362,-0.019974742,0.0024182547,0.01219736,-0.06464501,0.01109677,0.014528005,-0.034687538,0.026225654,-0.018636778,-0.059016407,0.011253266,-0.04047294,-0.03790895,-0.053110212,0.0020222,0.027877934,-0.048258066,-0.08007602,0.031948045,-0.07010583,0.008855619,0.0806814,0.10017511,0.009392546,-0.10401379,-0.11107642,0.03137752,-0.004508232,-4.7094528e-33,0.06739087,0.016308164,0.054303367,-0.050876692,0.008501158,0.040150825,0.018298397,0.020232199,0.01846067,-0.010737425,0.025226342,-0.02173471,0.117704526,-0.11707159,0.019997096,-0.011866356,0.0766869,0.0042280275,0.02037478,0.03073121,-0.047075216,0.039990928,0.027840411,-0.03261893,0.036587074,0.012621422,0.009020936,0.107109874,-0.0020301805,0.018174894,0.00572358,0.029903173,-0.04035996,-0.053711243,-0.04912989,-0.03663472,-0.060599364,0.004913265,0.014340702,0.03297731,0.026995331,0.006058557,-0.059065014,0.06684458,0.046513572,0.1135173,0.035409648,0.018588213,0.010539014,0.00356097,0.013646545,0.046817947,0.027657053,-0.0015730502,0.038204588,-0.003360565,-0.010605469,0.045539152,0.017351879,0.011441651,0.030509299,-0.07009227,0.0024286548,-0.078678556,0.016296422,0.034140725,-0.0546317,0.08482818,0.022835879,-0.03359503,0.10101073,0.082162656,-0.052386403,-0.046034988,-0.01605929,0.045770444,-0.01494247,-0.08095828,-0.014951379,-0.042023536,0.050129723,0.019277401,0.044562962,-0.011858248,0.041633412,-0.013453338,0.04584557,0.021582032,-0.020174842,0.05578735,-0.08928747,0.006818481,-0.08445972,0.03897655,0.032722037,-3.998019e-08,-0.006296301,0.033523485,0.1004118,0.0017255573,-0.018164925,0.04120836,0.01742458,0.028524164,0.03429475,0.013765498,-0.024846522,-0.033892114,0.07227371,-0.032541722,0.07434803,-0.021249546,-0.07801326,0.041296717,0.045659088,-0.0043715104,0.0076442515,-0.069871485,-0.08470997,0.021607727,-0.042213466,-0.029909577,0.035383653,-0.016025169,-0.020713052,-0.019552004,0.04217243,0.058101747,0.027434526,-0.018522922,-0.025293449,0.00041300702,-0.13822515,0.043663356,-0.0099325,0.014658005,-0.0072628637,0.008908657,-0.07194529,0.008887219,-0.039442167,-0.0024426812,0.03575536,-0.05503742,0.06664668,-0.03074884,0.045920182,-0.03729699,0.030971115,0.020925399,-0.025454078,-0.032111567,-0.036016006,-0.061743986,-0.03321682,0.029768383,-0.011491835,-0.086565994,0.13470633,0.032150015 +2.6.1.96,Requires pyridoxal 5'-phosphate. The enzyme is found in plants that do not have the 2-oxoglutarate dependent enzyme (cf. EC 2.6.1.19). The reaction with pyruvate is reversible while the reaction with glyoxylate only takes place in the forward direction. ,384,1.0,-0.040834207,-0.016787829,-0.04735373,0.010771576,0.055260815,0.04439773,-0.107534006,-0.051677134,0.03184378,0.084529534,0.035088155,0.017532704,-0.13002667,0.0207428,-0.04087142,0.0029338761,-0.06125057,-0.043333776,0.047685757,-0.0280095,0.10227551,0.013984738,0.00148274,-0.027910115,0.07439857,-0.031283844,-0.024552511,-0.0060852855,0.008574449,-0.05418755,-0.08052339,-0.0070464835,-0.037124358,-0.056041073,-0.0068276376,0.13706796,-0.06725365,-0.053346146,0.01532197,0.018475348,0.027594961,-0.004329378,-0.056609914,-0.055906408,-0.065669335,-0.012379183,0.044184964,0.0100070555,-0.0007594404,-0.0109994095,-0.038578663,-0.012299382,-0.05481513,-0.045881826,-0.019696502,0.010070549,0.052497894,0.04828729,-0.04085347,-0.026563162,0.0066107204,0.0036684058,-0.03874449,-0.028299447,-0.043818783,-0.05355119,0.02063278,-0.061906032,-0.019546432,-0.045012493,-0.061077107,-0.09561233,0.057583258,-0.03744654,-0.036643364,0.010461053,-0.0055180527,-0.011472882,0.04305224,0.044012085,0.009452115,-0.017952979,0.0030945435,0.036849607,0.006828097,0.03154308,-0.025749663,0.027052345,0.0057576294,-0.022370847,0.031198163,0.017109673,-0.020089535,-0.011831318,0.05248567,0.01946549,0.0623745,-0.0024867977,0.023480413,-0.07815889,0.013782271,0.057472702,0.016594335,-0.026927374,-0.08872669,0.06840839,-0.071623944,0.014757959,0.038453422,0.00063308235,-0.009316411,0.084581606,0.06906184,0.0351626,0.022349507,0.05563994,-0.0009916495,-0.07169847,-0.0913306,0.009634922,-0.006247477,-0.05086239,0.05462873,0.06621158,-0.07096779,0.044084653,-0.06317282,3.0525807e-33,0.07136129,0.047225393,0.0012073066,-0.014704814,-0.0025363155,0.0224181,-0.054305483,0.0012416982,-0.04938425,-0.027204175,-0.07337144,-0.055556543,0.036529157,0.008901441,-0.062191486,-0.0020292143,-0.023507996,-0.040269632,0.060282517,-0.051734816,0.058800284,0.036004167,-0.02800621,0.002259866,-0.031604856,0.09403982,0.0427856,0.004141982,9.95543e-06,-0.043873914,0.06833646,-0.12537472,-0.046381276,0.014336777,0.05492078,-0.009123884,-0.04853242,-0.045770522,-0.0076259812,0.038800754,-0.003073832,0.03438061,0.018479427,-0.022458201,0.074402064,-0.044920824,-0.012754191,0.0950275,0.0010409682,0.108840495,0.047452483,0.01543214,0.029839952,-0.02505307,-0.028605409,0.014510492,0.041939814,0.006109601,0.07154711,0.04655955,0.042163357,0.04766674,-0.016373495,0.009072208,-0.00011628247,0.08103882,-0.054871477,-0.04863921,-0.038302947,0.08645207,-0.03804887,-0.045730047,0.028357409,0.028327592,0.048503187,-0.062405206,-0.022214595,0.060618978,0.032382473,-0.03716701,-0.0018619869,-0.026747761,-0.022253314,0.007446348,-0.06971865,-0.07051864,-0.02877557,-0.013555647,-0.012021031,0.106716916,0.06692422,-0.061538547,0.04106146,0.029273324,0.043436483,-3.9456037e-33,0.1241117,-0.12619552,0.051139038,-0.08842777,-0.044991463,0.061842833,0.039419953,-0.08161225,0.030121094,-0.01826013,0.0014270182,0.022775514,0.059480608,0.04869737,0.041077137,0.041365016,0.0035118049,0.07001561,-0.0030800297,0.012733639,0.011561249,0.082918756,-0.00551399,0.027717952,0.09057896,0.0040475545,0.012280571,0.0391304,0.003244573,-0.060527213,-0.04344232,-0.0055261613,-0.053068444,-0.0433127,-0.027512064,0.011035534,-0.15537085,-0.013948051,-0.017783467,0.072973765,0.0114952475,0.08421558,0.01571844,0.06771098,0.01277595,-0.00091798237,-0.101781465,-0.029654013,0.019380026,-0.024758212,0.0015446966,0.060042504,-0.07172769,-0.0152255595,0.07105822,0.07949304,0.029202662,0.021415658,0.0065835486,-0.014574012,-0.013101268,-0.0841883,0.05514517,0.016101371,0.043243803,0.09148835,0.02427629,0.055094,0.04089422,0.087824516,0.0665489,0.034223966,0.044094082,0.013185376,-0.008249398,0.059706073,-0.07727247,0.02817134,0.00439251,-0.073681176,0.030134918,0.019969242,0.016031884,-0.07516068,-0.012257219,-0.121621974,-0.0015220756,0.07371115,0.040999506,0.024796175,0.025385687,-0.0819166,0.010815278,0.0064889835,0.16881281,-4.128998e-08,-0.050046917,-0.035970286,0.09111028,-0.03516783,-0.014690822,-0.004724074,0.08943673,0.003187504,0.029594405,-0.043206006,-0.014362566,0.04195669,0.044319887,-0.0013788785,0.042691883,0.010038659,-0.044890843,0.0395827,-0.023525922,0.009062397,-0.12220195,-0.037453838,-0.15745698,0.08337137,0.03505925,-0.03853902,0.018408306,0.02394722,-0.04114963,-0.029531721,0.039102692,0.042374726,0.0016630557,-0.06596474,-0.09809471,0.015944256,0.028487924,0.017696489,-0.051139724,-0.057360332,-0.035810985,-0.055338282,-0.012572589,0.010448263,-0.0338645,0.038002804,0.0116936425,-0.06135369,-0.033541374,0.04066907,0.07408449,-0.050592657,-0.01645309,-0.11341184,-0.09821816,0.015896915,0.01683721,-0.008531636,-0.040367797,-0.05347507,0.013186388,0.043846995,0.18228313,-0.09036932 +2.6.1.97,"In Euryarchaeota the reaction is catalysed by ArcS [1,2]. In Crenarchaeota, which do not have an ArcS homologue, the reaction is catalysed either by a homologue of EC 6.3.4.20, 7-cyano-7-deazaguanine synthase that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homologue of EC 1.7.1.13, preQ1 synthase [2]. The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors.",384,0.99999994,-0.112690955,-0.012286028,-0.07627557,-0.04784847,0.002986562,0.01842977,-0.0492244,0.037411284,-0.0033001339,0.029496584,-0.02790583,-0.11682977,-0.10716921,0.059442297,-0.08974398,0.08470209,-0.07265884,0.005781719,0.01575888,-0.025063252,0.02306314,0.035114214,-0.04669691,0.039281122,0.046072923,-0.008106649,0.03417316,-0.045411218,-0.025738068,-0.021072708,-0.05343456,-0.12178386,0.06297819,0.0127282925,0.031726692,0.0311269,-0.06613502,-0.11318922,0.05518012,0.050810758,0.040810425,0.081072174,0.042026576,-0.038216215,-0.06294194,-0.015524705,0.03533421,0.05782912,0.03891745,-0.013531252,-0.014824877,-0.04067434,-0.07872502,-0.019352213,0.016863273,0.077607006,-0.085955024,-0.03683255,0.022755882,0.0363946,0.08619251,0.0058114114,-0.028643018,-0.09615809,-0.03528963,-0.04857465,0.054284208,-0.019641913,0.09681516,-0.0031724814,0.016136846,-0.024330039,-0.051209986,0.044251762,0.02460511,0.008945791,0.025326476,-0.02315455,-0.028425725,-0.05703159,-0.009625668,0.018134922,0.050169736,0.027708964,0.010743135,0.05910877,-0.06174981,0.09118957,0.11237284,-0.022262335,0.083497204,-0.015651964,-0.01828952,-0.06365955,-0.0645502,0.024837907,0.079294436,0.072721295,0.0105958115,0.022476872,0.018853074,0.041054998,-0.06421814,-0.09281058,-0.032458022,0.030117553,0.05389281,0.0817816,-0.050065234,0.01599792,-0.005206859,-0.018114958,0.06118691,0.0029187808,-0.06301355,0.031158315,-0.00073242624,-0.0925224,-0.04515577,0.046751138,0.02789482,-0.019865708,0.04456133,0.103453614,-0.0036789486,0.05640699,-0.10634925,3.2419903e-33,0.019962063,0.03630133,0.016710337,-0.018421648,-0.02751007,0.029297551,-0.077650286,0.022783192,0.011770232,-0.11364596,-0.12596485,0.029802704,0.05067874,-0.014939795,-0.049308345,-0.016683875,0.01745776,-0.049599845,0.008943735,0.017816883,0.007784178,0.06182667,-0.033118702,-0.012105405,-0.004499825,0.005950954,0.013001,0.051246386,0.0038554205,-0.00237706,0.006424822,-0.06976661,-0.05816355,0.03371584,0.040965054,0.025262114,-0.03253141,-0.08209897,-0.014404529,0.017352605,-0.044553254,0.062294845,-0.021939937,-0.011896478,0.04751313,-0.013773095,-0.024475014,0.08022647,0.022261282,-0.038973,-0.0013307519,0.013016591,0.1125562,-0.036113843,-0.075506724,0.011889092,0.04820082,-0.06233485,0.11758108,0.07133212,-0.01832875,0.05877883,-0.0049242615,0.017675975,-0.0035845411,0.0492276,-0.05505857,-0.036614317,0.03815958,0.038039435,-0.067199156,-0.02713958,0.00055356976,0.10063553,-0.024096178,-0.08743138,-0.04208319,-0.0166425,-0.058315054,0.0384408,0.029132491,-0.045137513,0.041288186,0.04117113,0.02283946,0.014145553,0.010955821,-0.0027548927,0.031627655,0.08862243,0.017733509,-0.041295607,-0.0268273,0.00569257,0.057029452,-3.298808e-33,0.06818992,-0.083846875,-0.06698697,-0.04665769,-0.09584347,0.11086108,-0.01819213,-0.008081357,0.036542628,-0.03779605,0.090143934,0.021965187,0.0128267,-0.024121873,0.051769912,-0.06301647,0.030916525,0.0665816,0.010729518,-0.03084466,-0.009958501,0.03656868,-0.041502256,-0.0058327247,0.05409193,-0.0529242,0.020143764,0.035102643,-0.002773137,0.00701559,-0.033521593,-0.053276125,-0.011321025,-0.07623817,-0.049275257,0.00065615296,0.0286186,-0.031016702,0.02241731,0.010072341,0.06664155,0.03320201,0.016442483,0.09804056,-0.021558382,0.08791781,-0.044344094,0.08135125,-0.08430775,-0.04677567,0.03501218,-0.0546475,0.040266074,-0.076989375,0.058613762,-0.0150470575,0.09034985,-0.016633326,0.05058378,0.022777716,-0.00979456,-0.07625054,0.004117048,-0.05575429,0.039595317,0.0488149,-0.050156567,0.09273719,-0.024792304,0.028296156,0.046273943,-0.008247712,0.027534187,0.031857632,-0.046836216,-0.020137336,-0.028409313,-0.022696922,0.044849418,-0.1039184,0.029809412,-0.08452921,0.09387642,0.0046503753,0.008131547,-0.03325521,0.077535644,0.08601991,-0.046065114,0.084052846,0.026318543,-0.053296085,0.0052370476,0.08858407,0.08505959,-4.2539206e-08,0.024575105,0.0049896273,0.039183494,-0.06358602,-0.06899559,0.03534824,0.052173574,0.036897328,0.032203395,-0.006434401,-0.00035921903,0.029042266,0.01700574,0.035959836,-0.03941129,0.060996793,-0.024742436,0.03964788,-0.037232995,0.08709593,-0.048217565,0.028557751,-0.12002794,-0.010712126,-0.01337497,-0.061207898,0.062211916,0.10007457,-0.018599423,-0.08420328,-0.020181343,-0.035257302,0.0074591087,-0.0061427923,-0.06619379,0.009825242,-0.0358085,-0.04520174,-0.010893733,-0.092140146,0.011811054,0.044567723,-0.045290746,-0.020437295,-0.005235536,0.009309198,0.041114733,0.017811699,-0.022860255,0.009658746,0.060782507,-0.032621413,0.07574873,-0.067489885,-0.11146084,-0.057310276,-0.014141716,-0.093963645,-0.01871283,-0.007716706,0.06470507,-0.0063782264,0.10326735,0.024734976 +2.6.1.98,"A pyridoxal 5'-phosphate protein. This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the previous enzyme in the pathway, EC 1.1.1.335 (UDP-N-acetyl-2-amino-2-deoxyglucuronate oxidase).",384,0.99999994,-0.079464406,-0.08388161,-0.07506342,-0.051199306,0.0042724013,0.048672754,-0.049942993,0.029366564,0.0005065867,0.08886731,0.0072067687,-0.042102214,-0.058546975,0.027979536,-0.044799656,0.03743046,-0.072436444,-0.031314917,-0.022942577,0.0034245295,0.114883214,0.07497936,0.0020558452,-0.0033671793,0.024804654,0.06537395,0.098559074,0.031433914,-0.064195275,-0.016606418,-0.06521624,-0.08051528,0.045991436,-0.09871023,0.098223574,0.066836774,0.0028006881,0.014707671,0.09347223,0.0036609608,0.048716225,-0.051725257,-0.029828742,0.0128112435,0.00046208582,-0.015821978,-0.013414229,0.052425846,0.10425928,-0.031392843,-0.003071091,-0.03340969,0.0038991375,0.033813424,-0.031634048,0.039817806,0.044054277,-0.0034793161,-0.038783584,-0.0050080786,-0.026659979,-0.020738102,0.056359213,0.007939031,0.025329007,-0.01579561,0.05633256,-0.07954466,-0.0075757834,-0.0020895828,-0.057830386,-0.06268481,0.068421565,0.03414098,0.027571,-0.005372564,0.033121653,-0.057879258,0.019495228,-0.052415304,0.051806845,-0.058177877,-0.0020961557,0.15446095,-0.008032856,-0.04369214,0.008918196,-0.0783391,0.07782518,0.013136578,-0.07792956,-0.006863351,-0.009374417,-0.0035707345,-0.07031769,0.0058370195,-0.027980965,0.032087132,0.03768167,-0.064167,-0.03137496,0.026577756,-0.045739383,-0.10091299,-0.018359683,0.004420044,-0.008891639,-0.049560476,0.022382809,-0.009331534,0.018557595,0.010394872,0.0016575917,-0.0037813764,-0.014447668,0.011533721,0.028541205,-0.046656862,-0.08927731,-0.030266915,-0.011114651,-0.018895939,0.070519574,0.051111385,-0.08417409,-0.0141488435,-0.0611334,5.740619e-34,0.010963779,-0.0002490353,-0.019592255,0.00095375406,0.10466537,-0.04560132,-0.09178168,-0.05493916,-0.03715738,0.019729948,-0.045062475,-0.09652998,0.036434602,0.055011738,-0.055894643,0.079461865,-0.068987474,0.0010479052,0.0012292193,-0.010066249,0.012749309,0.09095086,0.03307588,0.017685099,0.079603806,0.09884477,-0.002016862,0.027045187,0.07213727,-0.0044383965,0.053410683,-0.08861564,-0.1662408,-0.09312796,0.056933116,-0.0044459826,-0.030645607,-0.03325263,0.026106829,0.04640394,0.018206133,-0.0117895575,-0.032688323,-0.0027847153,0.023070747,0.020789571,-0.056033373,0.0889597,0.026946586,0.03205327,0.037642602,-0.091045655,0.09300576,0.053328034,-0.036001585,-0.076449364,-0.071697466,0.010871146,0.06469877,0.10104577,0.07553109,0.04027735,-0.01905838,0.0039057862,-0.03972454,-0.025069712,-0.0012865087,-0.0007596633,0.0640722,-0.035275463,0.034868896,0.0006297834,0.04908076,0.060075246,0.015855249,-0.066585176,-0.032633413,0.05029261,-0.0005476816,0.02706628,0.0048643826,-0.044065025,0.016771277,-0.03149011,-0.057773046,0.028534403,0.029046139,-0.03138247,-0.028345497,-0.012090998,0.012281741,-0.08781192,-0.040715013,0.08816719,-0.03426747,-2.8154396e-33,0.055314757,-0.108773984,0.08193997,-0.07384915,-0.04979982,0.002295174,0.059750833,0.047162935,0.045338925,0.009633871,0.08087438,0.007861892,0.014878303,-0.0066779708,0.055241764,0.04234718,-0.05479558,0.062383536,0.012218011,-0.03543812,0.0535227,0.03909244,-0.018768128,0.09724287,0.047000397,0.023345936,-0.07212821,0.0803164,-0.009354209,0.06171386,-0.02688489,0.07181758,-0.06188406,-0.056855317,-0.032289457,0.06709122,-0.029197084,0.025431396,-0.0075480384,0.029430266,-0.05045663,0.053456675,-0.010907731,-0.048198443,-0.015365975,0.034253936,-0.042605795,0.0011444876,-0.013783483,-0.00224062,0.09600451,-0.018149462,0.058145203,0.001001821,0.020765241,0.031468745,-0.056523427,0.045181412,0.016669974,-0.031561144,-0.028438315,-0.114458054,0.08118958,0.066666074,0.031676173,0.12079054,0.024097865,-0.025359064,0.05898246,0.0013151524,0.0013455115,0.029922388,0.01991577,0.030057691,-0.029585231,0.0014101603,-0.08548679,0.020129042,0.016851466,0.01941466,-0.0043700375,-0.01195488,0.0023456907,-0.013352684,0.0011287237,-0.013256241,0.09274967,0.09204333,-0.031957556,0.042404298,-0.00015627942,-0.025320373,-0.054629732,0.05175023,0.03325859,-4.486649e-08,0.08550445,-0.03401183,0.09554157,-0.061781403,0.005310045,-0.041414242,-0.00478654,-0.012891954,0.07600903,-0.057073012,0.0178558,0.10554651,0.029539062,0.03951115,-0.025618033,0.013085268,-0.05028634,0.03335846,-0.004554139,-0.059736207,-0.05009578,-0.028952988,-0.13163716,-0.009472606,0.04525938,-0.018413713,0.022538256,-0.027643025,-0.0033562994,-0.020177403,-0.023899544,0.0007889927,-0.02834246,-0.08328601,-0.054133464,-0.0067259073,-0.04484359,-0.07850422,-0.07382128,0.007055643,0.015517238,-0.054813348,0.046671942,-0.005024502,0.007429345,0.0008369117,-0.032929327,0.03666403,-0.023963923,-0.024828108,0.07004386,-0.008768677,-0.06339039,-0.06849687,-0.19049604,-0.029835638,-0.04620304,-0.02540372,-0.02409999,-0.012766488,-0.059756175,-0.02161341,0.13222395,-0.04570962 +2.6.1.99,"This plant enzyme, along with EC 1.14.13.168, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.",384,0.99999994,-0.04674014,0.018756878,-0.095628075,-0.013020013,0.060737852,0.14404395,-0.05138951,-0.032678187,0.038416624,0.038385075,0.07595282,-0.067521,-0.12650327,-0.032314237,-0.028644448,0.0479033,-0.081233524,-0.00699605,0.028245894,-0.09083554,0.025935449,0.066847846,0.052395284,-0.02588782,0.06776603,-0.040758643,0.0042774854,-0.041920215,-0.027467452,-0.044032194,-0.012044034,-0.02700614,0.04849371,-0.019857079,0.017304838,0.080615185,-0.047458664,-0.11574462,0.0892003,0.020614877,0.0010892692,-0.006714408,-0.051494505,-0.03559444,-0.034618728,0.03522279,0.024891244,0.021771837,0.028014693,-0.07616583,0.01873402,-0.04612952,0.01457792,0.0023212899,0.03966577,0.0009610861,0.064241655,0.05478183,-0.05278931,0.06373206,0.013812612,0.03818192,-0.039326474,0.011903852,-0.005401223,-0.06963551,-0.022742385,-0.06424732,0.0044026305,-0.0166991,-0.056812078,-0.08328027,-0.017084233,0.019906003,-0.037109207,0.058935452,-0.044087786,0.0064942585,-0.00043361925,-0.055917688,0.030656567,0.024076551,-0.0128273545,0.06425715,-0.036219254,-0.049825903,-0.0021042684,0.051391892,0.022289138,-0.005097985,0.02341785,-0.055970732,-0.025847742,0.024948956,0.013469809,0.10155384,0.04909211,-0.071143135,0.0073774685,-0.05960942,0.033409905,0.08080277,-0.069797814,-0.0792604,-0.08124648,0.014982893,-0.031170527,0.015994702,0.039360717,0.0015256797,-0.038280167,-0.033948325,0.020005908,0.045577053,-0.03233024,0.05307608,-0.028441649,-0.05231734,-0.03215232,0.0037122176,0.047057,0.0040526395,0.033802073,0.12078225,-0.050746694,0.028944436,-0.09003725,1.0462242e-34,0.1378356,0.053887896,-0.026524715,-0.051263016,0.0050425124,0.016997995,-0.042694647,-0.015472514,-0.045204196,-0.05059508,-0.09176892,-0.13648152,0.050666213,-0.04470937,-0.062397983,-0.016323028,-0.1218754,-0.009250358,0.033541903,0.032011576,-0.05091677,-0.011670036,-0.11073358,0.026192028,-0.022645224,0.02368242,0.030471174,0.022888532,0.0348498,-0.03351798,0.027756637,-0.06870107,-0.053525496,0.03760655,-0.03149362,-0.070327826,-0.013245669,-0.06381851,-0.02436886,0.063022085,0.06378162,0.10421495,0.09233289,0.0023583674,0.050408617,0.01732745,-0.051318727,0.1301597,0.10934091,0.12622672,-0.005385982,0.011467065,0.109642796,-0.028847804,0.018751033,0.038791057,-0.02313145,0.033348117,0.04866106,0.0094522,-0.04846443,-0.018277002,0.009117595,0.010923673,-0.0014706134,0.061145183,-0.06965863,-0.09047625,-0.013907838,0.10941723,-0.09284244,-0.024066547,0.028006956,0.013719433,0.002162585,-0.0036085676,-0.038604047,0.009843473,-0.039752994,-0.006351588,-0.015423231,0.02248447,0.014479813,-0.0066506728,0.0023469422,-0.07903892,-0.05539306,-0.016048046,0.023833392,0.053155456,0.09759441,-0.026699442,-0.0408293,0.07247489,-0.017404186,-1.2445e-33,0.056265287,-0.06658955,0.0016481538,-0.11126662,-0.035862174,0.048035216,-0.011355496,-0.042931467,0.0184221,0.02883946,0.07863354,-0.021819608,0.08989877,-0.012855835,0.064975455,-0.043793816,-0.00525008,0.099599704,-0.022378147,0.059768748,-0.009420023,0.041750137,-0.03976766,0.0046516634,0.05882241,0.021894533,-0.042522296,0.052493952,-0.021876032,0.014395562,0.061610457,-0.062987365,-0.11301654,0.05510009,0.064276226,0.0242461,-0.06211888,-0.0092527615,0.0071345493,0.066844344,0.0037495636,0.0922585,0.046799142,0.008505564,0.058666077,0.0034744442,-0.066503525,0.028052825,0.0022894198,-0.05741668,-0.08396489,-0.055564713,0.023346424,-0.0036772154,0.030562388,0.03219329,0.0051560123,0.03510552,0.007366821,-0.060488485,-0.014271121,-0.034559023,0.08216605,0.009798968,-0.04243998,0.046845887,-0.01078156,0.024859086,0.0739857,0.04726948,0.066521145,-0.028085595,0.03576633,0.072466955,-0.05374202,-0.08342733,-0.0367515,-0.015747083,-0.044801492,-0.027880974,0.07570671,0.06326828,-0.024577186,-0.07008285,-0.033293042,-0.029759444,-0.021220192,0.11031004,0.049318,0.027003698,-0.025466772,-0.0030747734,-0.07777866,0.07443808,0.099789165,-2.940771e-08,0.020426458,-0.04551899,0.051116195,-0.00044493834,0.013905599,-0.011550581,0.025436396,0.01406196,0.013831805,-0.07640647,0.027143281,0.043821644,0.026377192,-0.0017876048,0.049980003,-0.07297313,0.031069094,0.10446777,-0.012478253,0.0024056523,-0.04350651,-0.022121407,-0.059019897,0.022422355,0.0012990402,-0.043723494,0.024833541,0.05218923,0.035125926,-0.050668765,0.03378279,0.050607163,0.019244635,-0.052368358,-0.0944382,0.06046486,-0.02104667,0.029945925,0.024562322,0.007197427,-0.009016233,-0.090056784,-0.042284273,0.0063847066,0.030700572,-0.0063544144,0.030935153,-0.028189743,0.012940109,-0.0056987614,-0.017943572,-0.028209763,0.02648804,-0.048006006,-0.06227025,-0.02461492,-0.045035936,-0.032494824,0.009266271,-0.059299253,-0.019953072,0.0509039,0.15336937,-0.0014197493 +2.7.4.27,"The enzyme from the plants maize and Arabidopsis is bifunctional and also catalyses the phosphorylation of pyruvate, phosphate dikinase (EC 2.7.9.1), cf. EC 2.7.11.32, [pyruvate, phosphate dikinase] kinase [2-5]. ",384,1.0,-0.09849201,0.014697085,-0.06947856,-0.006957325,0.08442863,0.05740374,-0.05025032,0.0068753744,0.050849568,0.0649755,0.03737657,0.0049976613,-0.10332027,-0.02913667,-0.022733001,0.077366576,-0.06931953,0.08067483,0.024152655,-0.096518345,0.068004034,0.062460043,-0.013683897,0.0097341435,0.07121273,-0.04559301,0.054673664,0.03463864,-0.0277485,-0.050494596,-0.061558396,-0.020573402,0.012671439,-0.013381235,-0.011974642,0.20656028,-0.03993853,-0.12520114,0.033398505,-0.05600227,0.13362613,0.0031692518,-0.015172476,-0.032126483,-0.07039288,0.047200203,0.0021411492,0.058439188,0.0062487717,-0.06360959,-0.031820595,0.010399636,-0.08377441,-0.048711453,-0.007011892,-0.0027366322,-0.007579265,0.075726375,-0.00898382,0.0139207905,-0.018005943,-0.009781848,0.020879809,0.019156575,0.010630493,-0.06292758,-0.004035867,-0.029859086,0.0024246967,-0.048276518,-0.0819359,-0.047161393,0.071229726,-0.027122654,-0.025271984,0.056844257,-0.089974046,0.042322807,-0.010297768,-0.020208742,0.046645686,-0.015222431,0.034894295,0.012810999,-0.03686749,0.023695098,-0.052029032,0.07718079,0.030283859,-0.008242366,0.026029138,-0.02409933,-0.0041708443,0.03224108,-0.034394905,0.06524099,0.04872666,-0.027267203,0.013821877,-0.049493592,0.0027273898,0.093435906,0.012043354,-0.061980277,0.0035819565,0.059884116,-0.00012502847,0.02135525,0.011804076,0.004372927,-0.015343224,0.055107173,0.046738252,0.020219699,0.0057685026,0.03210614,-0.035565507,-0.073281236,-0.0041306484,0.049715716,0.021663588,-0.032357596,-0.03317426,0.058780976,-0.11450178,0.04894379,-0.100576475,1.785765e-33,-0.012343971,0.04673086,0.030355744,-0.021162054,-0.01947102,-0.023421295,-0.036497645,-0.044813484,-0.07814524,-0.06734977,-0.07320144,-0.03292049,0.08370228,-0.003521492,-0.054929424,-0.05814927,-0.04401539,0.013277478,0.08563792,0.01651035,0.020473441,0.007036839,-0.08365146,0.056941804,0.020029312,0.060251568,-0.03045553,-0.01403585,0.016967079,-0.038688418,0.04453751,-0.039840467,-0.08320373,-0.0028717245,0.03581353,-0.08190238,-0.05222136,-0.041676667,0.0025524963,0.017923772,-0.09173732,-0.024199717,-0.011304461,-0.02194074,0.010970432,-0.03274799,-0.0059985365,0.11267301,0.0495051,0.06139581,0.06214553,-0.031327467,0.09765361,-0.04442898,-0.05997107,0.029443316,0.027187973,-0.05097577,0.019044327,0.060937393,-0.003894716,0.051584147,-0.03766018,-0.0021909422,-0.030040976,0.015110825,-0.073174864,-0.08146015,0.04141725,0.13590641,-0.038585477,-0.05075278,0.056894194,0.00019031584,-0.007871414,0.002887541,-0.02395149,-0.0033153195,-0.09289239,0.06022931,0.044741403,-0.004080173,0.0020409378,-0.025280561,-0.047303397,-0.031508394,-0.0798796,-0.061693702,-0.0031222005,0.06662783,0.015914846,-0.0009997312,0.016308496,0.033080664,0.01968019,-2.6364239e-33,0.1083736,-0.0076281787,0.05620944,-0.042221427,-0.041123517,0.028783191,0.032043938,-0.06712777,0.049325507,0.0079564145,-0.00066602696,0.0012563227,0.048397873,-0.023170583,0.011047276,0.04976472,0.0173473,0.11278129,0.031599924,0.005728582,-0.018664645,0.12263768,-0.023975326,0.0062537855,0.045112412,-0.007812347,-0.0107903145,0.03895473,-0.006569109,0.013366198,0.003468014,-0.013854091,-0.04294547,0.021902837,0.0011007575,-0.039423514,-0.07105458,-0.006430782,-0.006431589,0.018895078,0.0211871,0.07535222,0.043213036,0.046492867,0.0013152236,0.015804848,-0.021161681,0.07322936,-0.065325305,0.00454852,-0.018346487,0.06723537,-0.06405271,0.037450377,0.014177847,0.051623173,0.058139954,0.05552709,-0.009264619,-0.014515036,-0.04667991,-0.116529584,0.060778156,0.041223004,0.048005447,0.05465828,-0.0056902054,0.019652143,0.0130138695,0.09298525,0.05655134,0.05597085,-0.006244306,0.034890067,-0.06309957,0.04065101,-0.05173481,-0.023860544,-0.05931803,-0.0086659575,0.037812036,0.025978642,-0.020898882,-0.08641465,-0.05010599,-0.018355237,0.009345122,0.09589194,0.008797738,-0.002809317,0.002485946,-0.10658429,-0.031862482,0.022223258,0.06487599,-3.803229e-08,-0.01745087,-0.026405148,0.022409566,-0.07121154,-0.02805523,-0.029893944,0.07645934,0.043323908,0.04439197,0.028761353,0.0024347089,-0.0076399157,0.029493516,-0.019125747,0.059392642,0.006242157,0.013895791,0.07564276,-0.008631666,0.004268821,0.017600467,-0.042498935,-0.17190617,0.08245342,0.044934206,-0.060306266,0.005745126,0.015086515,0.013182635,0.018645314,0.030664943,0.0041517466,0.013460791,-0.11311467,-0.0282007,0.011564326,-0.044653043,-0.043990873,-0.012431417,0.0030943872,-0.0015226308,-0.056316953,0.03244755,-0.0033877203,-0.06509932,0.04097343,0.043870125,-0.0036458143,0.025786974,0.046540864,0.05620579,-0.02861803,-0.06980492,-0.13066833,-0.08499873,-0.01607759,0.007463893,-0.034294095,-0.016922902,-0.1140779,0.028668689,0.065624095,0.20403045,-0.09239572 +2.7.4.28,"The enzyme from the bacterium Escherichia coli is bifunctional and catalyses both the phosphorylation and dephosphorylation of EC 2.7.9.2, pyruvate, water dikinase. cf. EC 2.7.11.33, [pyruvate, water dikinase] kinase [1].",384,1.0,-0.06027549,0.0049063186,-0.06787573,0.02976822,0.050035425,0.038730826,-0.021836048,0.074984916,0.07431496,-0.023538344,0.0047834367,-0.062595755,-0.059461568,0.08083575,-0.008882934,0.006970139,-0.07678394,0.03664929,0.020022612,-0.09123052,0.06524033,0.007535984,-0.033039585,-7.947538e-05,0.0044206036,0.0030296799,0.16015069,0.038796205,-0.0661445,-0.063276626,-0.0004930833,-0.0869027,0.047648817,-0.061086982,0.05813495,0.17440996,-0.010460856,-0.14401232,0.08267739,-0.038495835,0.07458171,0.05742873,0.006947163,-0.003924439,0.010481373,0.046174083,0.043609295,0.07521844,0.012563415,-0.060338814,-0.02512541,0.008821782,-0.060385726,0.027508734,0.025023175,0.011074967,-0.041809138,-0.04913092,-0.0229032,-0.043422177,0.030624308,0.009855296,0.069293216,0.023452224,-0.01878099,-0.09111067,0.055141836,-0.045273263,0.038055442,-0.035902943,-0.10749634,-0.020968378,0.07090352,-0.0037831157,0.025286062,-0.020613678,-0.060628504,-0.0034416174,0.01484833,-0.014154608,0.026572857,-0.07732676,0.015957765,0.034871247,-0.0032697306,0.009425538,0.014098263,-0.019739304,0.019208806,0.005896723,-0.018956356,-0.04937514,0.04975094,-0.06807498,-0.03638558,0.036233447,0.0068882974,0.061591078,0.029501842,-0.054300305,-0.056334212,0.09942913,0.00017497197,-0.024940751,0.04691932,-0.024230557,0.0757557,0.13639927,0.033950984,-0.056859054,-0.007107878,-0.034080815,0.09567427,0.054989133,-0.00033547066,0.09046412,0.011949879,-0.07044667,-0.026781017,0.071667574,0.06465323,-0.075011455,-0.0072714374,0.059944466,-0.12622726,0.06277475,-0.106400795,2.6738805e-33,0.012846144,-0.023334555,0.074855775,-0.032743916,0.01954723,-0.041376058,-0.08132386,-0.040087372,-0.07219135,-0.07991644,-0.086979434,-0.027355984,0.09047703,0.007189099,-0.04795388,-0.08067403,-0.026248947,0.023658998,0.045594793,0.01246934,0.06932935,0.021455768,0.005016512,0.019702325,0.07122337,0.042624407,-0.022833584,0.03496269,0.03547649,-0.021238232,-0.024539549,-0.056007076,-0.065559976,0.03049946,0.035129063,-0.07593094,-0.040500566,-0.006235712,0.030973319,0.018937737,-0.047700442,-0.022738526,-0.034758586,-0.0399477,0.012262042,-0.033943906,-0.008057803,0.09972209,0.05547807,0.0574193,0.06773339,-0.040033843,0.09911941,-0.07826218,-0.032172285,-0.008080971,0.015043989,-0.015186489,0.026284905,0.056083918,-0.0030663933,0.09428382,-0.07406069,0.01564134,-0.010024983,0.017836748,-0.030218568,-0.046539526,0.059151288,0.08266743,-0.10986882,0.03382742,0.07369281,-0.014768978,0.017429698,-0.020533802,-0.09719339,-0.044474375,-0.042293705,0.060083758,-0.009581057,-0.004985698,-0.011860068,0.026221478,-0.0040110005,-0.012002948,-0.076115824,-0.03270806,0.005671918,0.10319895,-0.042785376,0.0001675874,-0.006508991,0.028746227,0.01998693,-3.6285802e-33,0.06458247,-0.07679493,0.005527764,-0.039515942,-0.05270084,0.08465405,0.011773064,-0.020155022,0.07039461,-0.0017452263,0.03982514,0.0042326036,0.017424991,-0.028055474,0.009567941,0.048694,-0.014188747,0.082052246,0.0017514867,-0.049524754,0.03129171,0.044252884,-0.013150754,-0.017588817,0.038969602,0.037668705,-0.007511846,0.04549963,0.003579838,0.036053885,-0.057264064,-0.008690591,-0.024359139,-0.017051985,-0.055325408,0.017360758,-0.03937079,-0.023038054,0.0105532715,-0.02191049,0.034793988,0.03152665,0.010849815,0.069458455,0.016744573,0.07794636,0.010330102,0.043584365,-0.004770673,-0.022416221,-0.019612316,-0.030237956,-0.06436671,0.0071891304,-0.018404692,0.051054504,0.034262363,0.068306796,0.0063311527,-0.0038553462,-0.049747713,-0.106059864,0.09100988,0.022467518,0.02048741,-0.010215893,-0.043824513,0.035515748,0.035959985,-0.012086388,0.08852373,0.014265195,-0.04971046,0.030401219,-0.009905499,0.00072684133,-0.099838555,-0.04496095,0.008658884,0.006452575,0.017789299,0.0375928,-0.052889436,-0.06451508,-0.025730994,-0.037084576,0.019001586,0.057224207,-0.015537237,0.009311649,-0.007552129,-0.07603368,-0.059449475,0.046361238,0.05298263,-3.7468695e-08,0.017538892,-0.0542123,0.047663126,-0.055551168,0.017209053,0.028289774,0.05334032,0.05098926,0.03241549,-0.021627976,0.03772367,0.00892299,0.012915451,-0.046175346,0.012209558,0.04069496,0.0016527014,0.0065733055,0.0068204817,-0.029827792,0.026271906,-0.07494051,-0.10442007,0.064886704,0.049681116,-0.076312006,-0.0050068363,0.015106183,-0.067342386,-0.06661843,0.0014966037,0.0006681189,0.003778698,-0.033862304,-0.02461544,-0.069213174,-0.10315227,-0.02809303,-0.034308676,0.045355212,0.031499255,-0.0066084745,-0.06215516,0.0048281807,-0.0298136,0.10039381,0.018114517,0.014861433,-0.012256941,-0.020193843,0.07759044,-0.048624408,-0.015393928,-0.039781634,-0.11828936,0.02665162,-0.01988376,-0.088762105,-0.030390266,-0.071542405,0.09356108,0.07110146,0.19144665,-0.046334263 +2.7.7.82,"Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.",384,1.0,-0.03263777,-0.033969615,-0.08949773,-0.019252224,0.02799627,0.09248385,-0.004356486,0.038088493,0.06952528,-0.01850253,0.047699876,-0.03900346,0.021364354,0.021724502,0.0033464083,-0.0633966,-0.014974086,0.00091267156,-0.05327552,0.030980486,0.024220876,0.061992228,-0.013942571,-0.04310399,-0.004440436,0.06887969,0.053801555,-0.008040659,-0.0020039899,-0.04944906,-0.044644605,0.019389099,-0.02438865,-0.10767114,0.09153325,0.037648473,-0.055555657,-0.041887153,0.16584282,-0.01583705,0.04964407,-0.015855499,0.052594192,-0.0751553,-0.020506408,0.07247581,0.02841971,0.03838098,0.08091927,-0.0275723,0.0076909866,-0.022606792,-0.0011231141,0.045264315,-0.0139449,0.04741499,-0.05759229,-0.008021373,0.009341604,0.03848124,-0.029274473,0.06607868,0.105785,0.035262693,-0.09139741,-0.082008794,0.063855454,-0.003570306,0.05810634,-0.050431002,-0.03621153,0.024784507,-0.023093717,0.027170248,-0.020468207,0.08177196,0.08311182,-0.036499463,0.06612808,-0.04082875,-0.018578568,0.013372348,0.03934797,0.13591287,-0.01367081,-0.044546828,0.013506153,0.07770661,0.11120526,0.033744194,0.013751549,0.0051173964,0.025116263,-0.057412203,-0.115882084,-0.025827976,0.005346085,-0.040282857,-0.017645251,-0.01121921,-0.012302892,-0.0264711,0.03944579,-0.07230192,-0.050654385,-0.020451738,0.03968697,0.040038105,0.035612676,-0.02820755,-0.0394605,0.015693732,0.00622028,-0.08269515,-0.048636764,-0.007749845,0.09062257,-0.1024581,-0.06118649,-0.014945256,0.04995204,-0.13581528,0.042705245,0.018831057,-0.015703848,0.030967906,-0.07374174,4.3403494e-33,-0.0014005377,-0.010479469,0.047228675,-0.028298875,0.03406052,-0.033364344,-0.030850867,-0.13548374,-0.10304509,-0.047849145,-0.06431963,-0.077588886,0.0069164247,0.08111508,0.032306455,0.054638017,-0.04364105,-0.03413882,0.04673246,-0.047196336,0.017413298,0.07188487,0.071915045,-0.043770824,0.06831693,0.00019498108,0.0024079932,-0.015127321,0.03994654,0.01154982,0.008304669,-0.053422682,-0.037363127,-0.025535261,0.073658876,0.057293087,-0.14876054,-0.07281006,0.0006945692,0.007976029,-0.028334629,0.09596522,-0.03874776,-0.018267026,0.0011138448,0.023188947,-0.07529209,0.010481142,0.056158144,-0.03128185,0.04901399,0.018967956,0.022185177,-0.00021745979,-0.031145427,0.012614988,-0.0019645337,0.019144505,0.0017862158,0.026891652,0.057213563,0.060036935,-0.073354416,0.036601163,0.057114672,0.01204669,-0.010229998,0.029754592,-0.00011676069,-0.052201204,-0.011576123,-0.03528523,-0.0444841,0.031664684,-0.04569603,-0.02734325,0.027907882,-0.04054177,0.0460582,-0.0051420317,-0.0075137913,0.0051116743,0.032976728,0.030262109,-0.1137972,-0.01897953,-0.012807074,0.03035024,-0.04824755,-0.056152374,0.065223984,-0.027883241,0.008930372,0.059812672,-0.11288651,-5.437396e-33,0.012853238,-0.033236086,0.05026216,-0.10640329,-0.0107215615,0.034585908,-0.00071470323,-0.012154342,-0.020206746,0.039973006,0.0016096476,0.047119338,-0.02198955,-0.033894375,0.0025250479,0.0061000027,0.081732236,0.10628528,-0.031792723,-0.033731394,0.034309186,0.019740896,-0.009576167,-0.042491578,-0.025181431,-0.0020585114,-0.03919969,0.07517199,-0.030478436,-0.00075247214,-0.0011391762,0.032970358,-0.052996956,-0.115239084,0.0067664622,-0.06724788,0.00720599,-0.0119802505,0.064800344,-0.04499999,0.025442801,0.04298264,0.016032232,0.035393447,0.041657463,0.031504802,-0.043014716,-0.06707361,-0.045025006,0.023480384,-0.06574118,-0.0653157,0.0017773684,0.014097861,0.027842972,-0.027407257,0.0275935,0.013319383,-0.0010190385,-0.08179798,-0.0547074,-0.025083002,0.010889047,-0.0033009483,0.039370634,0.13011532,0.07487506,0.0032870346,0.034535665,-0.06468127,0.038616963,0.040586557,-0.020463374,0.06673909,-0.01735932,-0.04789593,-0.08873582,-0.026916927,0.029907668,0.04666772,0.05775192,-0.07368597,-0.04812625,-0.01679544,0.061172973,-0.077940725,0.0455321,0.11288134,0.04016174,0.001744697,-0.015212253,-0.057848267,0.032528322,0.102344714,0.051658146,-3.8923226e-08,0.0061479188,-0.080655746,-0.023688802,-0.044915378,-0.086741924,0.036190305,-0.04403316,-0.02617612,0.06672778,-0.035059273,0.014621215,0.03122982,0.039700184,-0.0251133,-0.023159841,0.12224038,-0.06501157,-0.037634294,-0.020229347,-0.025215436,-0.07535525,0.021395221,-0.041259892,0.062336378,7.440754e-05,-0.05233172,-0.031810433,-0.03282792,-0.07317004,-0.0413134,-0.016932532,0.05629472,-0.03722988,-0.088857114,-0.07898062,0.048412137,-0.00863854,-0.06491074,0.051100556,0.07631801,0.024641408,0.03272541,-0.027430963,0.0074315974,0.10694074,0.03957953,-0.015050078,-0.0040221494,-0.053040046,-0.1154703,0.07446989,0.003734773,-0.039930496,0.0070623877,-0.110240065,0.024281107,0.011521443,-0.005447625,0.03925277,-0.041838218,-0.013575848,0.01555171,0.13357157,0.025675097 +2.7.7.83,"The enzyme from plants and animals also has activity toward N-acetyl-alpha-D-glucosamine 1-phosphate (cf. EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase) [1,2].",384,1.0,-0.060513783,-0.07614322,-0.047522556,-0.034944173,0.027347978,0.051112138,-0.020976981,-0.015999313,0.030628204,0.087465204,0.0016820369,0.047379263,-0.05455591,0.04127549,-0.09134929,0.039160624,-0.041353967,-0.06484842,0.04765081,-0.045820486,0.034618333,0.057712886,-0.03753282,-0.04344255,0.06364674,-0.032273907,0.027433025,-0.046721857,-0.016175304,-0.073272504,-0.04792371,-0.053292368,0.062418852,0.045019023,0.060785096,0.081690334,-0.04481013,-0.02696209,0.034926075,0.05027976,0.02536109,-0.0028907743,0.0054399306,-0.019023795,-0.10049986,-0.030657463,-0.04932247,0.013112612,0.06678959,0.01804143,0.017475475,-0.011468006,0.012976309,0.012893561,0.03716166,0.0009974214,-0.06857196,0.041092087,-0.06734007,0.07844974,0.0415189,0.028452361,0.005065681,-0.046243876,0.055918783,-0.055541426,0.03736806,-0.04593153,-0.020090813,-0.035788815,-0.046875056,-0.039339326,0.014708683,-0.035503678,-0.024116717,-0.017763223,-0.07853014,0.0052222135,0.07636825,-0.057016335,0.05729972,0.029296486,0.021942012,0.083934955,-0.014433015,0.043630686,-0.044313814,0.07699807,0.08949372,-0.05512615,-0.026985362,-0.092525534,-0.044224177,-0.045753986,-0.04292311,0.0012412387,0.019289877,-0.025798194,-0.04717864,-0.045534033,0.0009749571,0.06658058,0.015445565,-0.10790251,-0.081503145,0.09159307,-0.032988615,0.079171896,0.039275575,0.020270627,-0.07564947,0.06082962,0.01120793,0.054780994,-0.0674706,0.020771261,-0.025428612,-0.079508476,-0.049405888,-0.05321907,0.025966033,-0.029483642,0.035926983,0.09869612,-0.011691431,0.064699866,-0.03559654,-9.132934e-34,0.10404365,0.010984221,-0.0043148473,-0.042470496,-0.00033750298,-0.005407418,-0.04255918,0.0027300084,-0.0071119745,-0.03553593,-0.032103915,-0.024987554,0.112161,0.03793464,0.01754461,0.056705005,-0.01352018,-0.0062432466,0.096885026,-0.00035642443,-0.0034127547,0.03751634,-0.082895815,0.033765182,-0.006348168,0.014228684,-0.059753206,0.05129113,0.025926821,-0.02539115,0.017924163,-0.09077298,-0.10061514,0.04283253,0.04314173,-0.033559106,-0.0144763095,-0.060874153,0.042530607,0.02156333,0.03720126,0.032242708,0.07862097,-0.05762678,-0.019270275,-0.023815846,-0.0897161,0.040336303,-0.006280586,0.08986284,0.042752113,-0.01779522,0.11767821,-0.020156693,-0.031195048,0.07163319,-0.030443663,-0.045115817,0.036236398,0.07407413,-0.01806433,-0.058332644,-0.058663163,-0.046123456,0.009171769,0.013797127,-0.059452057,-0.05060379,0.044786546,0.13633274,-0.047053657,-0.043590162,-0.01762025,0.019697232,0.00068920635,-0.05475031,0.024187356,0.08827733,0.0018043242,0.045432065,0.037843384,-0.032510184,-0.012205709,-0.009270633,-0.06854419,0.032558277,0.06225327,-0.10213967,0.0071867057,-0.004762525,0.0011848483,-0.06304005,-0.055065356,0.016261056,0.05299931,-5.4271132e-34,0.09990024,-0.11356246,0.033785388,-0.0366598,-0.079132155,0.04964657,0.063434,-0.06653388,-0.019610977,0.0004430328,0.045256495,0.04421064,-0.024323918,0.008842243,0.042427592,-0.009427482,-0.018651973,0.09784052,0.040448833,0.03216295,-0.04870864,0.07295688,0.0071915668,0.02078302,0.087815,-0.051454123,-0.018998612,0.06198132,-0.014857202,0.021016266,-0.009071093,0.016826697,-0.029156683,-0.036011353,0.00019983348,0.0099653965,0.011471025,-0.03007604,-0.055699117,0.0058049094,0.019978324,0.07503363,0.018727273,0.036446057,0.046084568,0.050978083,-0.10779584,0.009398668,-0.10099415,-0.026952043,0.0075051216,0.040666103,0.025581015,-0.025964573,0.06772376,0.05897233,0.04437096,0.06397026,0.014836855,-0.03062822,-0.023151755,0.0078322105,-0.05659125,0.0004555622,0.030973619,0.055177692,-0.008723235,0.03137288,-0.0071895216,0.06005334,-0.010270706,0.0002587836,0.121458195,0.09941891,-0.028771866,-0.03505792,-0.035469428,-0.027096642,-0.009735288,-0.05908376,0.043480538,0.00817876,-0.06044821,-0.03759685,-0.03893566,0.015676118,0.059133172,0.12692492,-0.006941245,0.064794786,-0.07959168,-0.04657283,-0.08043521,0.037346587,0.078520335,-3.8795392e-08,0.041051902,0.020383878,0.025577312,-0.08567814,-0.008106045,0.005523551,0.03926638,0.019543368,0.062106036,-0.02427958,-0.025102643,0.12756084,0.04260036,0.05231981,-0.0073024794,-0.0013140991,0.0438756,0.0062539787,-0.037921127,0.059703156,-0.07843652,0.031882722,-0.10662804,0.010784855,-0.0077449246,-0.088395596,0.02140165,0.06809848,0.01188764,-0.009527656,-0.048094958,0.024612157,0.04913959,-0.15273538,0.022423638,0.052107025,0.007056621,-0.047654275,0.031759907,0.035205394,0.0072539537,0.013553136,-0.007887016,-0.014626631,-0.0060673165,-0.020496573,-0.0066265156,-0.031158978,0.009983614,0.020582391,-0.0148836225,0.0018114661,-0.06557915,-0.15925658,-0.090366915,-0.058319073,-0.05806219,-0.09545609,0.027292108,-0.047715627,0.003238608,0.033103313,0.13204385,-0.02845102 +2.7.8.36,Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway.,384,1.0,-0.027744778,0.018385416,-0.11108243,0.021446874,0.0049547264,0.043464202,-0.041303117,0.012134648,0.061302517,-0.019286921,0.061859746,0.00253857,0.024521617,0.081448264,0.020857397,-0.015008069,-0.0043795067,0.017163554,-0.04367812,-0.02032597,-0.039286,0.07664937,0.038453426,-0.06821934,0.0033546009,-0.054478772,0.08554149,-0.03237804,-0.000902486,-0.012026851,0.0017075988,-0.031845428,-0.040165402,-0.09087569,0.10805533,0.012410035,-0.028694041,-0.057790402,0.14869091,0.039422784,0.014815008,0.0011651426,0.067126006,-0.077828586,-0.031986915,0.0070542926,-0.008388698,0.061409652,0.101301335,-0.05288718,-0.07874027,-0.026875287,-0.01861798,0.0133327935,0.05263894,0.04002314,-0.0408099,-0.018988427,0.011101787,0.048595,0.0041890144,0.05770811,0.11407726,-0.020684384,-0.102287,-0.068143085,0.027642924,-0.010622733,0.04483727,0.018415084,-0.068785146,-0.039378345,0.0313839,-0.02204115,-0.016261134,-0.02131186,0.004289336,0.055760123,0.05892828,-0.009172667,-0.0060313544,-0.009957948,0.14844555,0.010103235,-0.08892335,-0.031714268,0.049869727,0.074498884,0.09602652,0.062785506,-0.013741214,-0.032268267,0.022972679,-0.05309896,-0.045620475,-0.080542706,0.05633755,0.027061049,0.013734122,-0.013526715,-0.012812923,-0.05831364,0.10287487,-0.028342107,-0.086411804,0.027894266,0.09621372,0.08616292,0.05598804,-0.032246105,-0.026491294,0.09276958,0.029780107,-0.07723438,-0.07242756,-0.017548425,0.059333943,-0.029880766,-0.012381129,0.044578608,0.0804016,-0.032427356,0.09789566,0.013640588,-0.012474195,0.057688225,-0.030238258,-4.976212e-34,0.0765464,0.03810261,0.078978345,-0.022685349,0.049888775,-0.0513423,-0.053543046,-0.075546235,-0.0802513,-0.006555458,-0.06125726,-0.06982872,-0.0138955675,0.06753776,0.020743735,0.030317705,-0.09196018,-0.012552031,0.05244816,-0.046629667,0.0022598067,0.007898458,0.047372825,-0.093167685,0.036587436,0.023490043,0.027766306,0.020392608,0.0057023624,-0.021869002,0.05135052,-0.076271646,-0.10551912,-0.008037435,0.08632195,0.018431714,-0.022914639,-0.017248925,-0.008279961,-0.04912961,0.0033576505,0.09234792,-0.0007185602,-0.018697178,0.018107971,-0.023039594,-0.04984953,0.03369682,0.061911006,0.04448619,0.016416654,-0.04170328,0.04255065,0.03360604,-0.067183055,0.02402908,0.04309744,0.016547706,0.04379668,0.052787736,-0.022443365,0.062208477,-0.030652866,-0.012098245,0.046869565,0.0129809445,0.012269045,0.0073377965,0.02622401,-0.03000155,-0.0015761713,-0.02207034,0.094467975,0.032042082,-0.044399623,-0.06571607,-0.00132857,-0.039849482,0.029797547,-0.018040342,-0.030332083,0.0043634945,-0.001944678,-0.019489842,-0.08145869,0.030243738,-0.09172163,-0.032506276,-0.011499445,0.057553694,0.04399021,0.016436737,-0.056669287,-0.0039635943,-0.014925812,-1.2100887e-33,0.043700457,-0.013491187,0.062322926,-0.060908347,-0.05034451,-0.041367736,-0.025445644,-0.03882529,0.009492213,-0.004822238,-0.0068983585,0.08271312,0.08656272,-0.0065116137,0.052782547,0.035649408,0.027289098,0.078713976,-0.028792728,-0.046818588,0.056452554,-0.047341444,-0.053757362,-0.10250222,-0.0043904856,0.0062141484,0.03776899,0.11170505,-0.027032085,0.003891128,0.047168806,0.03465062,-0.089512154,-0.12884311,0.045879044,-0.045399085,-0.07929899,-0.028363274,-0.0028769686,-0.13458334,0.04687283,0.04032676,-0.01670106,0.0797996,0.020211121,0.058946993,-0.056955244,-0.041354008,-0.032639794,0.009141498,-0.10109658,-0.0520914,-0.02999763,-0.04274978,-0.01019751,0.03211152,0.019155754,0.031141326,-0.0070208255,-0.02660843,0.012672343,0.018761428,0.014661665,0.005613988,0.063391745,0.026125308,0.05153083,0.00034115394,0.10036847,-0.070650406,0.05545179,0.0079370905,0.008066585,0.06947224,-0.013874777,0.028384142,-0.0920702,-0.011600869,-0.0070387265,0.020570679,0.10338226,-0.06551433,-0.023799384,-0.068823144,0.05643251,-0.016040897,0.058723174,0.11336757,0.042927355,0.015234517,0.02003133,-0.05545976,-0.0021499814,0.07064398,-0.03272654,-2.0954381e-08,-0.021503763,-0.11358849,-0.020426705,-0.06776843,-0.06815409,0.04049961,-0.03935522,0.0037241257,-0.01503337,-0.013002537,0.017980145,0.017699583,-0.05525096,0.015297324,-0.04647773,0.09118837,-0.090951785,-0.01712048,-0.008192939,0.037164703,-0.1105839,0.021723831,0.0060308636,0.06849712,0.002480712,-0.05401336,-0.0077026645,0.094231665,-0.036702476,-0.07518471,0.023449127,0.06821256,-0.04619008,0.010536587,-0.10892281,-0.05021941,-0.022123624,0.011399803,-0.013226509,0.024766803,0.011073811,-0.019192645,-0.030938398,-0.01475575,-0.02211003,0.040405173,-0.06608647,0.0254686,-0.06580764,-0.079134636,0.015736667,-0.0076612,-0.03611455,0.01683709,-0.10790916,0.029651465,0.013454666,0.03204511,0.027138673,-0.040290207,-0.09367788,-0.01311271,0.05623256,-0.02532384 +2.7.8.37,Isolated from the bacterium Escherichia coli.,384,1.0,-0.07909442,-0.02448093,-0.114510484,0.041953772,0.017848171,0.03926226,-0.027097216,0.06519545,0.043959063,-0.04552074,0.08314315,-0.038169194,-0.006173411,0.04109008,-0.027136778,-0.042954918,0.03230206,-0.0015897375,0.009218124,-0.029983819,0.031393986,0.11901161,-0.021579113,-0.029717384,-0.031747717,0.046222813,0.07444686,0.010929896,0.016175045,-0.07881615,-0.01229077,-0.06601076,0.048521634,-0.079462305,0.1404767,0.042580623,-0.0060372776,-0.047056243,0.18468918,-0.027205441,-0.057778865,0.033794507,0.061454315,-0.034682356,0.022445869,0.023847895,-0.014220077,0.062489003,0.077773,-0.06750922,-0.023691852,-0.014543173,-0.017475195,0.047346957,0.06040526,-0.025574818,0.012454542,-0.09969409,0.0015510124,0.050605435,0.056233592,0.027208045,0.04228029,0.03487901,-0.05562999,-0.063895084,0.032295015,-0.0031827756,0.08672793,-0.07005111,-0.008105803,0.0178591,0.06916732,0.09602672,-0.047443643,-0.040391978,0.026908183,-0.017676733,0.05400527,0.07874454,0.022199115,-0.05324752,0.034964107,0.07757862,-0.02692293,-0.033427123,0.040181533,0.09663872,0.021851012,0.044914696,-0.04952181,0.024279723,0.03011045,-0.08049242,-0.027118396,-0.055419296,0.008951629,-0.011206515,0.04431301,0.019425653,-0.024576027,0.023365825,0.06603167,-0.08100541,-0.07438733,-0.01888881,0.015349642,0.03344319,0.046409607,-0.00015219345,-0.017677808,0.047749083,-0.045810007,-0.059251774,-0.001704984,-0.024729885,0.12100084,-0.05390708,-0.032748174,0.037127465,-0.0097377505,-0.05778811,0.09205018,0.012245072,-0.03978878,0.022940824,-0.05016902,-1.1541489e-33,0.008950131,-0.016467746,0.05153162,-0.010173946,0.04766623,-0.014493455,0.0076248473,-0.070738085,-0.072730765,-0.0072501507,-0.060537502,-0.07525238,0.00049968646,0.0035611868,0.02270296,0.028404107,-0.024801746,-0.00209136,0.020636406,-0.06757562,-0.012389792,0.07925631,0.045975443,-0.025907485,-0.017712828,-0.021993434,-0.05293795,-0.03038245,0.040858295,0.0064336895,0.023395414,-0.038638856,-0.06986162,-0.022990154,0.08381779,-0.011565861,-0.09954448,-0.04679874,-0.008540554,0.07348936,0.084886074,0.0661537,0.05557674,-0.010210157,0.059814177,0.034149144,-0.07680249,0.028833685,0.05824411,0.000687618,-0.019052012,-0.013221276,-0.011997416,-0.06919642,-0.079392895,-0.03528781,0.018407827,0.043077007,0.026320426,0.039521348,-0.0027314448,0.16130789,-0.07807034,0.042630825,0.037578817,0.020525122,-0.050965518,-0.023214392,-0.07232932,0.0449864,-0.024955276,-0.042893685,0.03187883,-0.08055885,0.0034331242,-0.04521096,-0.05884602,-0.0055004046,0.014460065,-0.06865058,-0.050354607,-0.007836776,0.004808921,0.026391082,-0.0771912,0.08490451,-0.05117045,0.064515,-0.0050343727,0.081551924,0.020674827,-0.044124495,-0.08732109,0.023904698,-0.04118846,-1.4545046e-33,0.077663094,-0.024712553,0.0076767164,-0.09036549,-0.061207473,0.10041089,-0.053526253,0.053976025,0.00046998987,0.04655402,0.004558951,0.048561037,0.082404524,-0.051432874,0.04332525,0.067465,0.07012102,0.08247932,-0.073242836,0.008839442,0.0008278202,-0.04598901,-0.0033469577,-0.079986826,0.013837954,0.054334957,0.027871944,0.049068604,-0.025805157,-0.0059154285,-0.0012759538,-0.040391136,-0.060774703,-0.11330849,-0.100243226,0.025709178,-0.05956129,-0.087938905,0.038183782,-0.052524514,-0.029338107,0.08105271,-0.04670054,0.071121566,0.005426919,0.061188642,0.02601788,-0.0026911031,-0.016780308,0.041451532,-0.028168457,-0.06305295,0.0072477446,-0.095598765,-0.019903827,-0.056318004,-0.036048535,0.06737809,-0.025193483,-0.01947666,0.042661548,-0.004135351,-0.041248072,0.006439566,0.06060104,0.100968,0.0040517184,0.042852815,-0.05139464,-0.078822814,0.025424741,0.04204094,-0.023067836,-0.0013929117,0.011702029,0.022255974,-0.09584443,-0.066309,0.024452347,0.029749947,0.04272574,-0.056387056,-0.022342106,-0.010169663,0.058836214,-0.08122202,0.04593934,-0.033315405,0.06825669,-0.008488028,-0.019270785,0.017927581,-0.052265663,0.0062406184,0.040483505,-1.9371914e-08,0.058250003,-0.07516481,-0.0008629088,-0.0006708294,-0.010887484,0.039770648,-0.016865285,-0.003919416,0.06089332,0.05141354,-0.012026404,0.004459893,-0.015383217,0.042418122,-0.0014857599,0.016691113,-0.042454656,-0.011140986,0.008938356,-0.004404264,-0.065405056,0.0036871096,0.030326212,-0.005333561,0.0067746225,-0.052430984,0.06901451,-0.07615917,0.0015696719,-0.047876757,-0.06951545,0.020552697,-0.059059527,-0.022806445,-0.06548809,-0.0071677295,-0.03541757,0.010319132,-0.051917724,0.024896901,0.036495455,0.016409919,-0.07724267,0.030313589,-0.035396647,0.036691636,-0.04680331,0.030938033,-0.06900379,-0.085089155,0.0468344,-0.0134332,0.050763994,0.030187305,-0.11004082,-0.0022892763,0.011755509,-0.1010746,-0.022628453,-0.01665104,-0.030850846,-0.013698407,0.14737655,0.09931997 +2.7.11.32,"The enzymes from the plants Zea mays (maize) and Arabidopsis thaliana are bifunctional and catalyse both the phosphorylation and dephosphorylation of EC 2.7.9.1 (pyruvate, phosphate dikinase). cf. EC 2.7.4.27, [pyruvate, phosphate dikinase]-phosphate phosphotransferase [2-5]. The enzyme is specific for a reaction intermediate form of EC 2.7.9.1, and phosphorylates a threonine located adjacent to the catalytic histidine. The phosphorylation only takes place if the histidine is already phosphorylated [3-5].",384,1.0,-0.08126583,0.029158752,-0.09644266,-0.047213245,0.07807655,0.06622955,-0.037391197,0.044071984,0.04792915,0.06939669,0.0786438,-0.0131617235,-0.044262983,-0.016905632,0.0026140218,0.00085687614,-0.08726105,0.015186195,-0.0042686122,-0.124474265,0.07624965,0.07407287,-0.037136488,-0.020240031,0.032947674,-0.06731157,0.020365305,0.003008977,-0.05033947,-0.046930876,-0.067783825,-0.08846118,0.018152343,-0.014839404,0.035040807,0.1625802,-0.040796343,-0.12005297,0.048058216,0.02603033,0.09354272,0.048666637,-0.080883846,-0.042412654,-0.06300823,0.041475993,0.03062484,0.020958964,-0.024700707,-0.046767958,-0.040426377,0.020356249,-0.048647743,-0.030070124,-0.042840503,0.017732691,-0.008405318,0.030977728,-0.008325623,0.029809183,0.0051388997,-0.03215744,0.06833954,0.011726263,0.029033488,-0.074000984,0.028190928,-0.03626636,0.0014787155,-0.06269647,-0.062253166,-0.041700177,0.05491545,0.040041696,0.034967788,0.024588717,-0.08200937,0.04122511,-0.031113222,-0.026681382,0.027178021,-0.045518525,0.0026312098,0.003272392,-0.0016070767,0.00058921165,-0.054517604,0.016382422,0.06662076,0.013884779,0.047323287,-0.068553865,0.0021430003,-0.016631022,0.0009800665,0.066537075,0.03833283,-0.017250123,0.00078243733,-0.062014643,0.03555223,0.06586694,-0.0769852,-0.008528724,0.015097833,0.08299796,0.013111799,0.04799117,-0.03033088,-0.0039711106,0.02049718,-0.037405245,0.063805096,-0.014933825,-0.013596321,0.09616626,-0.014935605,-0.061041735,-0.0038729177,0.024036784,0.039972927,-0.033809897,0.066715516,0.0885436,-0.08976796,0.0541283,-0.16623323,4.617819e-33,0.011260376,0.07282349,-0.018285517,-0.032160066,0.004468251,-0.015817344,-0.08506822,0.052259378,-0.019560203,-0.11527658,-0.06266531,-0.050283667,0.08735952,-0.063921876,-0.10387315,-0.05474443,-0.020226534,0.043898307,0.057304714,-0.02825152,0.022947809,-0.03913597,-0.01844654,0.04137564,0.054672092,0.04635141,-0.062825665,-0.021220662,0.045665484,-0.024877008,-0.024215378,-0.06451433,-0.051335014,0.028195148,0.053501952,-0.036752433,-0.064547345,-0.028284602,-0.014564503,-0.0014632741,-0.04584813,0.028384594,0.012895032,-0.03178837,0.014045539,-0.025214035,-0.02301175,0.080623046,0.0762507,0.013364315,0.040782906,-0.041962527,0.1218202,-0.06824312,-0.028365506,0.035168,0.035421122,-0.030679986,0.033429913,0.09859279,0.04801492,0.06306926,-0.026817579,0.026587836,-0.010213426,0.029762765,-0.15917577,-0.07259282,0.032988332,0.132383,-0.039073154,-0.047184132,0.0901995,-7.1705996e-05,0.047087815,-0.005796365,-0.08013622,0.030828314,-0.10838185,0.025536193,0.05502944,-0.0073805903,-0.027853189,0.04168629,-0.023220008,-0.043662753,-0.0069205584,-0.049118176,0.024172483,0.06994748,0.023115598,0.0005477268,-0.0033922251,0.0049886913,0.009855248,-4.6847065e-33,0.0696569,0.010928786,0.05176701,-0.041079216,-0.0071375268,0.02459892,0.021917265,-0.032695744,0.056528825,-0.024158662,0.029137097,-0.019988842,0.015114357,-0.031072108,-0.023801124,0.029669344,0.049453426,0.09970289,0.022419143,0.024652366,-0.022841528,0.04417161,-0.010664286,0.026502544,0.06340152,-0.04422783,0.00024006373,0.027671546,0.009694786,-0.0060668946,-0.04805618,-0.010514022,-0.07866165,-0.010890209,-0.019247225,-0.019877328,-0.107977726,-0.022590166,0.041426703,0.032408837,0.04995382,0.020755017,0.05710049,0.039963406,0.008772108,0.05485465,-0.028989483,0.10733668,-0.07915054,-0.008858875,-0.019605057,0.02810778,-0.07918153,0.054277923,0.03394371,0.0720834,0.074371904,0.08140001,-0.01464677,-0.027618185,-0.014334865,-0.11056825,0.012694119,0.012302286,0.035871428,-0.0008975964,-0.047325704,0.031885687,0.027442805,0.07204496,0.0501248,0.020333052,-0.005082041,0.0023934625,-0.039904892,0.0027735038,-0.05908896,-0.052223694,0.012088874,-0.058554243,-0.036593214,0.015426091,0.008365548,-0.07993383,0.002764941,0.0057735713,0.030453444,0.07794232,0.004811144,-0.007016674,0.0040038372,-0.10191458,-0.0017682504,0.018275915,0.04459175,-4.518639e-08,-0.0005255419,-0.04437942,0.013772431,-0.02142148,0.0034837439,-0.007384816,0.053264577,0.02606803,0.051678784,-0.0022790534,0.0090083005,0.03286811,0.028742803,-0.032991584,0.037261873,0.02805766,-0.00040480163,0.081077054,0.0071195303,0.007338827,-0.0048563904,-0.009954353,-0.16000725,0.043753535,0.03202628,-0.029001152,0.016952304,0.026608748,0.014307969,-0.06374491,0.059943635,-0.030550614,0.048723117,-0.111785956,-0.05012228,-0.041954376,-0.061037757,0.008879479,-0.0022067828,-0.009946444,0.0037875501,-0.0060757105,-0.025796479,0.044858128,-0.033583775,0.047964137,0.035925083,0.04849689,0.012478308,0.034514993,0.036130853,-0.04297683,0.0027421634,-0.13034491,-0.025044404,-0.08856611,0.01416755,-0.049427025,-0.023258463,-0.015865782,0.08497088,0.09079986,0.19203751,-0.056614604 +2.7.11.33,"The enzyme from the bacterium Escherichia coli is bifunctional and catalyses both the phosphorylation and dephosphorylation of EC 2.7.9.2, pyruvate, water dikinase. cf. EC 2.7.4.28, ([pyruvate, water dikinase] phosphate) phosphotransferase [1]. The enzyme is specific for a reaction intermediate form of EC 2.7.9.2, where it phosphorylates an active site histidine [1]. It has no activity toward EC 2.7.9.1 pyruvate, phosphate dikinase (cf. EC 2.7.11.32, [pyruvate, phosphate dikinase] kinase).",384,1.0000001,-0.04808112,-0.0054685087,-0.07593914,-0.039031297,0.072483644,0.052099355,-0.041898612,0.076644205,0.029847011,0.0075059235,0.02020176,-0.040238988,-0.035137463,0.09047887,0.008529645,-0.016669692,-0.06430105,0.0021859815,0.026629375,-0.09337581,0.08628955,0.055334978,-0.018247887,-0.017023548,0.0031478375,-0.001004222,0.13073035,0.026187133,-0.05350221,-0.06571422,-0.014658726,-0.11580262,0.065433264,-0.065808974,0.06731035,0.15401697,-0.036230814,-0.09965959,0.071412615,0.025244338,0.054103665,0.066175625,-0.0007391072,-0.026141446,0.019228699,0.025245884,0.032596935,0.034939505,-0.008478962,-0.038001645,-0.041311074,0.015921293,-0.026407396,0.002709288,0.008430201,-0.008275208,-0.04415616,-0.023910392,-0.024709864,-0.026399229,0.037181012,0.004841406,0.0908535,-0.00040126845,-0.021587407,-0.07711467,0.07154759,-0.06297302,0.026809473,-0.059269175,-0.10108252,-0.022463657,0.077167675,0.035410866,0.038714338,-0.027785763,-0.06264755,0.010480923,0.0014796912,-0.01008519,0.00014451236,-0.091981076,-0.004399988,0.031977057,-0.008487756,0.0067591295,-0.015092883,-0.009303329,0.020544143,0.020383522,0.0084471945,-0.048634563,0.04252321,-0.06456997,-0.016635973,0.020989787,-0.02158227,0.07289724,0.011873623,-0.06932925,-0.017994199,0.10336296,-0.06334577,-0.030087713,0.038203906,0.007335714,0.06307967,0.14030625,0.0070603783,-0.045925945,0.016339233,-0.02060402,0.062253702,0.012932012,0.010152287,0.09523057,0.018247519,-0.075558946,-0.03653039,0.06720826,0.079655856,-0.07868705,0.07215327,0.10174978,-0.12060562,0.05821405,-0.1229887,4.122053e-33,0.009027525,0.012048242,0.056579746,-0.03046644,0.00090593094,-0.0079976935,-0.11669923,-0.0075889113,-0.0389172,-0.09509323,-0.07350342,-0.024862278,0.103773735,-0.02228229,-0.053313743,-0.06953982,0.0036100026,0.016653799,0.05914636,-0.014389532,0.106354915,0.01638487,0.018871877,0.043600637,0.07808135,0.040019672,-0.048698377,0.03707118,0.03751142,-0.024412226,-0.045441907,-0.07309221,-0.072256684,0.026434068,0.03419909,-0.08579034,-0.055742946,-0.029520651,0.012590786,0.012885866,-0.039822504,0.0011386058,-0.011686607,-0.046431325,0.04610081,-0.0612892,-0.008577972,0.10161363,0.07624946,0.03990613,0.044348374,-0.042143323,0.117784165,-0.09330641,-0.038609713,-0.0059855203,0.04105441,-0.012653959,0.052067857,0.08439433,0.03987649,0.06611285,-0.06309252,0.0012904933,0.009121879,0.023708442,-0.047855552,-0.05357433,0.017135963,0.08545157,-0.08663472,0.037165537,0.07591471,-0.010670034,0.057291135,-0.0539288,-0.10997544,0.015774257,-0.035802726,0.016311036,0.019746974,-0.0031974742,-0.0039834264,0.020920578,-0.0012408965,-0.024713071,-0.042900205,-0.030287575,0.0010024224,0.09870875,0.0028454298,-0.019628616,-0.03762535,0.017491706,0.040374912,-5.0943295e-33,0.06640395,-0.05938271,-0.005098216,-0.043194823,-0.059061214,0.07362834,0.03284831,-0.00015318251,0.084602356,-0.047091786,0.039603412,-0.00920445,0.020354845,-0.03771403,-0.018028198,0.055996448,0.009302418,0.09706675,-0.018521832,-0.030639645,0.012142023,0.04568778,-0.0020140838,0.0074109314,0.03219789,0.013336259,-0.0063089887,0.042822793,0.024787843,0.038862206,-0.058321744,0.007313989,-0.04988301,-0.024697011,-0.06223673,-0.008068485,-0.10471403,-0.023967467,0.010716066,-0.010855696,0.052226383,0.024551876,0.024745237,0.02146639,-0.0021410927,0.113270216,-0.01447099,0.093645774,-0.04060086,-0.03477297,-0.04248943,-0.012635384,-0.054978646,0.009547968,0.01803685,0.05810526,0.039200082,0.076413356,-0.0012450203,-0.0047420277,-0.023606595,-0.0942591,0.039292976,0.016101047,0.015054109,0.004314061,-0.073913135,0.05116762,0.037776336,-0.004110439,0.063485906,-0.018116798,-0.014031808,0.0049953577,-0.02835106,0.017412359,-0.08064738,-0.022823853,0.03990625,-0.010827696,-0.001363302,0.009690237,-0.03340402,-0.069999844,0.005003442,-0.022994708,0.012130508,0.05351925,-0.0074588615,-0.0062534623,-0.007802798,-0.06906066,-0.04622085,0.023518298,0.053204548,-4.895201e-08,0.02668252,-0.049887866,0.05828501,-0.04878585,0.012646159,0.022485191,0.051944487,0.023896078,0.043214668,-0.017741097,0.015514091,0.03046512,0.015256193,-0.07087093,-0.0046884264,0.03876804,-0.011155926,0.015575099,0.016071178,-0.031181687,-0.01726799,-0.08222517,-0.12502284,0.04123662,0.043771904,-0.045352455,0.0135777965,0.032195687,-0.022556005,-0.095748946,0.016105706,-0.032393645,0.0030325686,-0.050793104,-0.040849384,-0.039991967,-0.09755382,0.013150718,0.015130253,0.044601556,0.041316163,-0.041608714,-0.073681556,0.028175106,-0.0050732465,0.115372375,0.01001691,0.050036598,-0.024985306,-0.051015284,0.04854845,-0.048212294,-0.010098587,-0.06604649,-0.08718486,0.013869659,-0.018684633,-0.09610596,-0.0079175,-0.054527074,0.08896156,0.053344335,0.16343178,-0.021633193 +3.2.1.182,The enzyme from Triticum aestivum (wheat) has a higher affinity for DIMBOA glucoside than DIBOA glucoside. With Secale cereale (rye) the preference is reversed.,384,1.0,-0.03160952,-0.10838939,-0.09539683,-0.046007056,-0.03454175,0.03130848,-0.07035525,0.09134403,0.03420241,0.0065102056,0.09094655,-0.037369967,-0.084912084,-0.04664708,0.0052367514,0.015094371,0.12652835,0.016724046,-0.06806552,-0.08344472,0.05286994,-0.012240161,0.0110548325,-0.029934302,-0.012847858,0.01759428,0.020693617,-0.008532889,-0.021267992,-0.11857105,0.01614682,0.07594106,-0.03954906,-0.022922138,-0.022654632,0.008368418,-0.015683074,-0.07413156,0.0660383,-0.04161675,0.01729661,-0.02357821,-0.001922595,0.0048364177,-0.05516873,-0.053699594,-0.033121474,0.066285305,0.0381891,-0.0048981137,0.00753173,-0.045663677,-0.05518927,0.021331294,-0.062297754,0.04397215,-0.03436348,0.03115888,-0.039531425,0.069727294,-0.021746479,0.06871122,-0.03632174,0.048976477,-0.025882395,0.0033232928,0.025481315,-0.033459254,-0.025079196,-0.048604824,0.0020199413,-0.06718397,-0.012927851,0.07062578,-0.03217895,0.025333129,-0.023713332,0.06223338,0.017318118,-0.0347829,0.048966005,0.050323945,0.08823922,0.07436849,0.034171756,0.004668909,-0.027349195,0.015013599,0.06404512,-0.04865552,0.14160286,-0.033337865,0.02302944,0.07396794,0.017924344,0.016597666,-0.06523964,-0.03972843,-0.07413632,-0.05077897,-0.048717767,-0.04150794,-0.0691604,0.020478597,-0.055537336,0.07084734,0.020697892,0.004634528,0.08585327,-0.00703006,-0.0058923513,0.068557546,0.0007532122,0.04225661,-0.07136169,0.0054884315,0.09363429,-0.031316992,-0.010286885,-0.024521748,0.03695847,-0.0013000411,0.037093457,0.010073698,-0.07289952,0.029865114,-0.012198208,4.5755993e-33,0.020557303,0.03546835,-0.009218793,-0.07438035,-0.03847519,-0.039203126,-0.022641987,-0.021613069,-0.06396025,-0.01972315,-0.105543695,0.02000391,0.020878704,0.035960685,-0.020063546,0.042408682,0.010947343,0.0065505006,0.011837127,-0.052718177,-0.040453512,0.08158657,-0.020036554,-0.009010962,0.011066256,0.047821846,0.07154685,0.018851684,-0.050948005,0.008976766,0.001642793,-0.080370516,0.03265491,0.057942595,0.052584607,0.042430993,-0.023989607,-0.037899733,-0.01421213,0.06436327,-0.029469782,0.022035437,0.05790715,-0.007062042,0.07867143,-0.041125227,-0.015764922,0.09150662,-0.037445948,0.04495429,0.047940347,-0.0009862953,0.0027472195,0.10845657,-0.020154884,0.069867454,0.035049595,0.07856478,0.03665924,0.03177817,-0.040018287,0.08546701,-0.021457324,-0.078037634,-0.032637596,0.03161709,-0.11889352,-0.0728438,-0.09417449,0.11361949,-0.033839222,-0.030985724,-0.020380283,0.06835608,0.07235308,-0.08518775,0.044169866,0.08507848,-0.00038483358,-0.03764595,0.09542472,-0.037149023,0.028803533,-0.012821002,-0.13020515,-0.0005319368,-0.07287428,0.0138179995,0.0142859155,-0.006089369,0.096027926,0.08688257,0.012068646,0.061070807,0.0029574216,-3.680254e-33,0.009242393,-0.035288215,0.0034467,0.062328555,0.017949352,0.010619885,0.019964088,-0.10806142,0.011033072,-0.015014629,0.057995446,0.071932696,-0.038999636,-0.043324877,0.029865667,0.08834901,0.00209872,0.055966064,-0.004975195,-0.071738176,-0.02499569,0.07392178,0.005298484,-0.09457395,0.04968594,-0.07473952,0.016727848,0.055830248,-0.027409691,0.00040583656,0.024053829,-0.026469462,-0.028444443,-0.07248756,-0.023790395,0.03086408,-0.02507479,-0.007857472,-0.030696187,-0.0037367148,-0.12432946,0.042380184,0.05197758,-0.0089481585,0.013394358,0.0478772,-0.07390591,-0.058501054,-0.013665457,0.08417589,0.054275926,0.0014913538,0.07064117,0.057099737,0.011583628,-0.01005838,0.028680295,-0.047528844,-0.06879289,-0.0026347192,0.031567674,0.0104513755,0.06545079,-0.031554013,0.10398767,0.01994999,-0.02658399,0.06741338,-0.040446088,0.053136658,0.07796275,-0.063281365,-0.040717456,-0.0073032053,-0.05026937,-0.0071196975,-0.048989557,-0.047646485,-0.07976339,-0.013717819,-0.02732427,0.043127608,0.014850173,-0.014587878,-0.056803413,0.06305673,0.0030793909,0.09138951,0.072589815,0.09470074,-0.024214808,-0.091806896,0.03439545,-0.0049261483,0.1299577,-2.8600864e-08,0.0144586675,-0.046935037,-0.068955444,-0.0030913136,-0.021991888,-0.042216774,-0.033017382,0.011845566,0.0014755222,0.028230814,-0.041642077,0.11446295,-0.096721105,0.08141553,0.024162171,0.030375367,-0.0048134145,-0.021100888,0.023877664,0.072870694,0.058524493,0.02288432,0.015137993,-0.0092522325,0.012586705,-0.04612515,0.023801653,0.0055971215,0.048591863,0.04037434,-0.030144481,0.08427597,-0.0036003285,-0.053053696,-0.106189646,0.016928054,-0.057547435,0.07273167,-0.017099865,0.025440982,-0.010604453,-0.02914333,0.026557922,0.013352054,0.041424472,-0.061241813,0.075708784,-0.056404576,0.03557596,-0.022132052,-0.027452601,-0.012607381,0.007067282,-0.009021811,-0.062741354,-0.041093476,-0.054532494,-0.04946559,0.05725197,-0.08995388,-0.022262404,-0.08686649,0.10013845,-0.012459235 +3.2.1.183,"The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus. It catalyses the first step of sialic acid (N-acetylneuraminic acid) biosynthesis. The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers [2]. The mammalian enzyme is bifunctional and also catalyses EC 2.7.1.60, N-acetylmannosamine kinase. +cf. EC 5.1.3.14, UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing).",384,1.0,-0.018014703,-0.07394362,-0.093615755,-0.006110076,0.07912919,0.04490761,-0.044608615,0.024328763,0.042835027,0.012870205,0.027195591,-0.020146437,-0.07307458,0.022689788,-0.075739466,0.05572595,-0.07702646,-0.09687617,0.08184797,-0.05181132,0.06431018,-0.0014923431,-0.053066686,-0.05575904,0.030373152,-0.030015329,0.0574376,-0.04195485,0.004905446,-0.09678052,0.056125283,-0.11733318,0.13357486,-0.014648162,0.0393397,0.07526607,-0.025864938,-0.02833601,0.03335535,0.07111414,0.029459825,-0.02733446,-0.04392705,-0.02152502,0.010813447,-0.0186847,-0.012564267,0.008777321,0.028710645,0.063094184,-0.030935751,-0.005754086,0.0213486,-0.02459176,-0.02277908,0.020797752,-0.0031994416,-0.00920843,0.002595855,0.0367679,0.047907773,-0.029343832,0.034885347,-0.03854493,-0.035279717,-0.031101905,0.10362533,-0.09989979,0.0047697295,-0.01698859,-0.0790136,-0.040586222,-0.019552715,0.03930892,-0.02004968,-0.029262906,-0.022683542,-0.03098139,0.084515415,0.030621571,0.0076629193,0.011779204,-0.0066784383,0.1007287,0.04925273,0.015539383,-0.03371199,0.011347484,0.033973757,0.030891629,-0.041228067,-0.058346037,0.025166886,-0.051624756,-0.037918057,0.045962863,0.0092641665,0.01616646,0.030714827,-0.05374407,-0.002750227,0.04738194,-0.028028235,-0.115681104,-0.022634458,0.081184104,-0.035914782,0.08703015,0.09768432,0.05059966,-0.018837538,0.015212102,0.030689867,-0.0053159134,0.03238354,0.12021686,0.0018668134,-0.074250214,0.009754328,0.03927688,0.04291786,-0.031565633,0.051880978,0.09265144,-0.021247396,0.08208934,-0.05998795,2.4051806e-33,0.03714774,0.06853359,-0.0022249254,-0.020415043,-0.030529475,0.019729238,-0.045394123,0.032771498,0.00546565,-0.112402946,-0.017655862,-0.09961912,0.032043003,0.07236439,0.016932173,-0.055171527,0.040162396,-0.023357214,0.026793567,-0.044459097,-0.023416275,-0.0075840782,-0.046876892,-0.007315449,0.0047026845,0.029439442,-0.040139843,0.043775007,0.045194447,-0.014476057,-0.057834607,-0.028566422,-0.10498916,0.032704424,0.040126078,-0.055198163,-0.008194854,0.0063582323,0.04595375,0.08017629,0.004950978,0.064574376,0.052893974,-0.0479941,0.043818668,-0.028658694,-0.07665076,0.050583217,0.048746973,-0.031631544,-0.0050699143,-0.022515425,0.054137826,0.03037537,-0.02493666,0.018012758,-0.062393934,-0.05619375,0.024469139,0.03579672,0.017674265,0.022495983,0.013560056,0.069930986,-0.07580628,-0.04495683,0.015952867,-0.013908209,-0.009228425,0.04419985,-0.014881534,0.007220985,0.08760231,0.0005443549,-0.036186617,-0.04237691,-0.03490404,0.01589916,0.060047176,-0.0153251095,-0.055678457,0.024216108,-0.02622679,0.016749427,-0.061928496,-0.025006687,0.027980927,-0.060967345,0.02619503,0.031040255,-0.009813964,-0.09993485,-0.09924845,0.078192174,-0.04729898,-3.940565e-33,0.0991921,-0.08315029,0.06104025,-0.06404017,-0.053135134,0.07508014,0.06082542,0.021867316,0.04275793,0.018502118,0.046132196,-0.03299408,0.027840888,-0.09349757,0.092722274,0.027212365,0.07744825,0.17635323,-0.010330435,-0.049820773,0.03034305,-0.0049184915,-0.052500214,0.015580947,0.06592062,0.0019870105,-0.0035470093,-0.008620827,-0.010221724,0.09752849,-0.045186553,-0.003451237,-0.04765725,-0.057398316,0.025555309,0.05517183,-0.014570047,-0.014064192,0.00075835193,-0.039747443,0.062540926,0.067801714,-0.011867667,0.09897849,0.06378413,0.061921123,-0.028973851,0.034771264,-0.0047289818,-0.06808518,0.037102804,-0.04710819,0.008170052,0.0074557858,-0.058069553,0.035495266,0.01571089,0.0076816897,-0.052076858,-0.018433008,-0.09755164,-0.017680159,-0.02171908,-0.025637425,-0.0032022973,-0.022378225,-0.048022453,0.06574474,0.011539378,-0.045936998,0.019271066,-0.014612854,0.027529735,0.116329364,-0.009789028,-0.047460772,-0.060963176,-0.08932934,0.007355989,-0.08935707,0.017483344,-0.0034525916,8.912233e-05,-0.0479924,-0.049105372,-0.049063813,0.07711935,0.044416167,-0.0063126595,0.052122142,-0.055357765,-0.021384262,-0.11496613,0.08017323,0.046498083,-4.5858126e-08,0.04790395,-0.042165402,0.0447396,-0.10641046,-0.027113413,0.021702228,0.030993124,-0.0076098386,0.055555116,-0.069184236,-0.05651867,0.10569085,0.014896259,0.024221577,-0.022807203,0.026266254,0.02137848,0.032117497,-0.014964569,0.022273727,-0.062643886,-0.0048491857,-0.07724296,-0.016300406,-0.031350642,-0.058922224,0.008129689,0.06152433,0.015489863,-0.000892175,-0.08025588,0.030497545,-0.023552693,-0.020737961,0.0034830363,0.06726984,0.018952565,-0.09868469,0.011414904,-0.0320612,0.027375527,-0.008794047,-0.04348847,-0.0045755035,0.009346149,-0.01141709,-0.056973886,-0.027280899,0.0020362556,-0.02339707,0.011230768,-0.042905733,-0.017548302,-0.037687447,-0.0669938,-0.051476665,-0.06423466,-0.08032315,0.0584242,-0.104164615,0.04943584,0.08250444,0.21224265,-0.004430008 +3.2.1.184,"Requires Mg2+. Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates. The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose, which rapidly mutarotates to a mixture of anomers [1]. The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine [2].",384,1.0,-0.039581493,-0.04260612,-0.053156495,-0.041954428,0.025115635,0.022512864,-0.005897038,0.04442669,0.029077623,-0.026666528,0.006696917,-0.04639528,0.050296996,0.04431901,-0.012936043,0.003280726,0.034165096,0.032526575,-0.050506625,0.006635075,0.0395988,0.03424047,0.013130534,-0.014515978,0.004278077,0.057517145,0.07297564,-0.030153949,-0.025617491,-0.071308844,-0.039147567,0.023607828,-0.01047193,-0.11587286,0.08026675,0.018363055,-0.028050253,-0.026241887,0.102747686,-0.018734,0.04520251,0.016228529,0.069693215,-0.058301095,-0.012446928,0.03053833,0.067261286,0.018853294,0.13630523,0.008895909,-0.023551825,-0.0025050156,-0.016640294,0.043305494,-0.013232053,0.037232324,-0.10326616,-0.029665189,-0.025326058,0.008401115,-0.047348723,0.05856252,0.09678925,-0.001958385,-0.038536116,-0.0793682,0.024889186,-0.048832126,0.027074313,-0.0590097,-0.038396467,-0.019974764,-0.014461504,0.03403452,-0.055661082,0.1031168,0.123097904,-0.020549918,0.113937214,-0.04554132,-0.009374098,0.013936748,0.09823902,0.09478138,0.0011411984,-0.025779318,0.04607881,0.08000222,0.15550207,0.07646553,0.03991189,0.0075000217,0.021823123,-0.043529734,-0.073587336,-0.011153236,-0.019946637,0.011279889,-0.02611608,0.027951779,-0.022877166,-0.020105945,0.0236141,-0.046342984,-0.06229664,-0.013617752,0.010909403,0.06310903,0.053395025,0.008830501,0.015766438,0.018316986,0.031523213,-0.014994323,-0.063067436,0.022118473,0.037483454,-0.10177277,-0.07292224,0.011461997,0.0968647,-0.13308683,0.036145452,0.040881034,0.022019884,0.065220386,-0.08919748,6.510333e-33,-0.008200651,0.020877495,0.066564865,-0.0068840864,-0.010518805,-0.018633863,-0.08179621,-0.07170346,-0.037710775,-0.04476146,-0.094255425,-0.07301562,0.014017218,0.07262623,0.014966919,0.030909115,-0.053398676,-0.029100696,0.050559774,-0.0023111643,-0.0043315296,0.06278316,0.04509674,-0.041416638,0.06659381,0.034269366,0.0005048678,-0.02911198,0.04901365,0.0077918274,0.041427497,-0.12966715,-0.025498873,0.019225808,0.07211384,0.045458194,-0.11941731,-0.08560167,-0.0071250894,-0.0051795905,-0.08810702,0.065507494,-0.09966568,0.0088503705,0.022939608,-0.06527246,-0.031723566,0.021277126,0.047719453,-0.0024659901,0.053255353,0.008882187,0.047682967,0.0048520253,-0.048243266,0.025414307,-0.039545693,0.012265462,0.0644239,0.0037717763,0.043037105,0.046450872,-0.03779473,-0.0006570804,0.07055964,-0.013083058,-0.015920492,0.010076108,0.02877351,-0.026507685,0.013774056,-0.052914526,-0.024817536,0.071492985,-0.023769122,-0.060869142,0.0417764,-0.01031186,0.051970124,-0.030169314,0.0059612487,0.0053851567,0.02716585,0.025609212,-0.09373849,0.0017447387,-0.0112169925,0.0055931495,-0.037266966,-0.041020382,0.074551225,-0.03198133,-0.01447635,0.028436761,-0.073392294,-6.0039785e-33,0.04909013,-0.06989029,0.05311897,-0.082014896,-0.029719932,0.003457033,0.030190192,-0.022583012,-0.010160779,-0.031229425,0.018840577,0.011659143,-0.006024905,-0.06477595,0.023721736,-0.014348411,0.06238118,0.13024881,-0.037705258,-0.04815131,0.04420159,0.064125665,-0.04468794,-0.015534963,-0.023417862,0.01255583,-0.020975444,0.06625489,0.03332769,0.03754582,-0.014474202,0.07925142,-0.010800934,-0.0987945,0.033834055,-0.009002733,0.018279029,-0.024637913,0.027094211,-0.02037969,0.0005550006,0.07085288,0.013660445,0.025894834,0.023583088,0.05329069,-0.074592,-0.024468333,-0.0057145082,-0.021644887,-0.039479714,-0.07335138,-0.024636604,-0.013913918,0.019070515,0.009273188,0.034840632,-0.021186765,0.030584656,-0.050510347,-0.036526807,-0.059518207,0.042177036,-0.026853755,0.002641991,0.13213691,0.037454724,0.045064203,0.033091635,-0.00532044,-0.0030880768,0.009126389,-0.0079251565,0.033714302,-0.015264935,-0.016987177,-0.06249764,-0.02471389,0.07827283,-0.021928713,-0.012533564,-0.035444748,-0.02084251,-0.017513745,0.04936867,-0.085785136,0.04851933,0.13453794,0.0075804526,0.018379364,-0.0133289145,-0.112009585,0.008354687,0.113538034,0.035913315,-5.243673e-08,0.050189026,-0.112571135,0.0010261013,-0.039308622,-0.04835142,0.06837774,-0.064467706,-0.052860316,0.06488548,-0.07293062,0.03990933,0.04191062,-0.007848237,-0.03267993,-0.02531302,0.09850862,-0.059251726,-0.032404505,-0.062517345,-0.023481444,-0.07189063,0.022049056,-0.11657298,0.03369437,0.005260959,-0.03579916,-0.04309498,0.0015448716,-0.07181574,-0.03148129,-0.04226517,0.040781885,-0.0071223425,-0.09752623,-0.10747158,0.0062129567,-0.022646435,-0.059985436,0.05755388,-0.0049465643,0.039546765,0.027842851,0.020716786,0.0018896608,0.10644944,0.005292504,-0.009357331,-0.027775066,-0.07761488,-0.0901848,0.12018978,-0.006208112,-0.05575965,-0.031539835,-0.09781777,0.011167888,0.015860928,-0.07103138,-0.003377495,-0.04359332,-0.01711078,0.008008216,0.13398233,-0.029844463 +3.5.1.111,"The enzyme, which is highly specific for its substrate, participates in the nicotine degradation pathway of several Gram-positive bacteria.",384,0.99999994,-0.034354795,-0.013019738,-0.035457533,-0.030776152,0.014576109,0.074703045,-0.04976834,0.051057797,0.03954922,0.015827222,-0.031761464,0.007836686,-0.037284814,0.034730855,0.020669058,0.0009675077,-0.046647225,0.087802745,-0.013986095,-0.024324976,0.111722134,0.07407237,-0.030724458,-0.012248064,0.0077637867,0.0028467916,-0.015491473,-0.04141851,0.021707386,-2.0264048e-05,-0.037817433,-0.033662118,0.06865031,-0.017191637,0.041859295,0.045413658,-0.073633835,-0.02667017,0.096442215,-0.062605314,0.025115054,0.0969132,-0.05181384,-0.017741114,-0.041057337,0.037252318,0.06234255,0.005330144,0.0014347344,-0.044536017,-0.016824247,-0.03490639,-0.017531317,0.024041297,-0.0079873055,-0.014761766,-0.022086777,-0.020133812,-0.025967833,0.026218178,0.049950637,-0.0013690519,0.01859803,-0.013268782,0.048149675,-0.08386901,0.05550427,-0.044699978,0.0043171034,-0.024794433,-0.13027644,-0.09374286,0.0018974689,0.028266808,0.016585745,0.03774941,-0.09673784,-0.011819139,0.037070476,-0.021428866,0.08143246,-0.021424526,0.027984383,0.12834656,0.016547544,-0.08134845,0.06728283,-0.0068782563,0.10343442,-0.0033556088,0.012688202,0.0049255467,0.025615346,-0.014467466,-0.13326555,-0.024273677,0.024046741,0.030343644,0.0049666194,-0.010990491,0.02288721,0.06777536,0.023473065,-0.052126233,-0.051145963,0.03649735,-0.00072606426,0.04490823,0.04951916,-0.0101639675,0.00913227,0.036578517,0.011480586,-0.017777057,-0.014727633,0.089053325,0.0263851,0.0026417058,-0.06449683,0.042751253,-0.062730275,-0.05170202,0.053628415,0.044726882,-0.042692684,0.04073394,-0.057483684,-4.5491723e-33,-0.025310451,0.0029754478,0.025300322,-0.009154297,0.062475845,-0.01973342,-0.039420325,-0.01839533,0.0033019444,-0.037480384,-0.008280767,-0.11775939,-0.010633621,0.050967563,0.015965423,0.043500725,-0.06518909,-0.040506605,0.026629806,0.0012221481,-0.015825687,-0.036873057,-0.03744592,0.01757996,-0.0052758506,0.06053506,-0.029795678,0.026572574,-0.06025649,-0.030620866,0.02973858,-0.057140965,-0.15423676,-0.082060866,0.12158185,0.045249388,0.029796638,0.0127903195,-0.061517507,0.011762393,0.00693679,0.045244373,0.043285728,-0.03418829,0.0355513,-0.054422602,-0.0542689,0.0793648,0.061703093,0.056349967,-0.008575568,-0.12401169,0.07257838,-0.047068227,-0.06974329,0.056405358,0.048368815,0.0292393,-0.044570804,0.011389767,-0.006583261,0.018324729,-0.061936356,0.05538021,0.0029404864,0.045138113,-0.03179553,-0.11012771,0.043447204,0.11039114,-0.058291778,0.02454375,0.0062634936,-0.03466984,-0.010703158,-0.077012226,-0.10200382,0.05044723,0.051911503,0.026311303,-0.05136874,-0.116014615,-0.049200933,-0.058376323,-0.083151385,-0.05639732,0.056962706,-0.081363715,0.0033670599,0.028724503,0.059577063,-0.036704477,-0.010765788,0.09642786,-0.027094403,1.6628025e-33,0.028900929,-0.06901475,0.07277274,-0.058918588,-0.047563218,0.081248425,-0.00087492,0.009428517,-0.041352622,0.007651404,0.0012944884,-0.01600083,0.050246224,0.046804022,-0.008620975,0.046327077,0.010604052,0.038183734,-0.048444845,-0.0033900605,-0.038072847,0.1237341,0.014298295,-0.002036983,0.00050333067,0.00030118765,-0.0048112012,0.12728593,0.058812976,-0.022587663,0.011203783,0.07034813,-0.0068960637,-0.018830022,-0.031579886,0.026715057,0.013007349,-0.015945744,-0.0026214467,-0.024086865,0.077110894,0.038076736,-0.008093915,0.044498064,0.026192356,0.03340564,-0.040681493,0.06215627,0.006059671,-0.026335943,0.057233237,-0.039110582,-0.044333134,0.060029402,0.0016514594,0.06571071,-0.059526578,0.008404575,-0.06781998,-0.021109413,-0.09123124,-0.050962888,-0.011641171,0.013226594,0.04694728,-0.0020014863,0.0035298008,0.026225122,0.079768136,-0.08409199,0.032495618,0.029821115,0.045760073,-0.013790852,-0.09889603,-0.03748947,-0.089916356,-0.04216068,0.056596063,-0.04936021,-0.0049917833,0.030955559,-0.043563467,-0.07469331,0.012551211,-0.043066774,-0.053140122,0.12165615,0.019867208,0.038290534,0.005866976,-0.06747647,-0.075412855,-0.008891428,-0.0027265123,-2.632871e-08,0.05815662,-0.05497235,0.003207976,-0.01833381,0.026565423,0.054566022,0.015730167,0.04882033,0.066133045,0.0026588321,0.011470272,0.06950589,-0.042404253,0.034498665,0.0047753546,0.06072205,-0.103140675,0.04403596,-0.03281813,0.05410543,-0.09064184,-0.05174873,-0.020666646,0.06596979,0.059752002,-0.04375495,0.034020748,0.04087962,0.012780803,-0.041682485,0.021729197,0.037714023,0.025617654,-0.012615678,-0.10909963,-0.007750192,-0.017471984,-0.057105407,-0.0009044191,0.064094774,0.04824188,0.002158413,-0.16419472,-0.016833464,0.025972905,0.03928176,-0.00802526,0.0333372,-0.039519295,0.002938499,-0.0054853675,0.008368346,0.0036309867,-0.028426327,-0.16367719,-0.048864607,0.007570218,0.011982065,0.025522342,-0.05539758,0.079629,0.0022984033,0.18375286,-0.031415306 +3.5.1.112,"Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. The enzyme from the bacterium Streptomyces fradiae can also accept 2'''-acetyl-6'''-hydroxyneomycin C as substrate, cf. EC 3.5.1.113, 2'''-acetyl-6'''-hydroxyneomycin C deacetylase [2].",384,1.0,-0.002934958,-0.07001729,-0.094809495,-0.04103819,-0.02246374,0.045503214,-0.12188157,0.047256276,0.071679585,-0.010437252,-0.022092063,0.020812288,0.118131794,0.112830825,-0.052049965,-0.031028712,-0.07353111,0.011407902,0.0033815466,-0.02041526,0.021116143,0.07531469,0.022463389,-0.033015493,0.07322652,-0.030258916,0.0027337254,0.05962259,-0.042479623,-0.079330906,0.050682772,-0.029793797,0.024544822,-0.021766378,0.09200712,0.071298994,-0.06279862,-0.026941791,0.15722848,0.04867771,-0.08146079,-0.03785684,-0.024390668,0.046691153,-0.020810967,-0.05088763,0.027748087,0.053781297,0.065793596,0.028578047,-0.06422742,-0.020444773,-0.05395498,0.0656903,0.09328373,0.06724554,0.0027322706,-0.06185504,-0.00562518,-0.014434798,0.03495958,-0.03509103,0.026428215,-0.018078838,-0.12694368,-0.029457347,-0.0066701556,-0.076858595,0.07236763,-0.0069289636,-0.09738992,-0.094693966,0.053055853,0.039839424,0.0041867895,-0.02857823,-0.024203407,-0.041052073,-0.06447453,-0.04623565,0.0034092392,-0.058677644,-0.0028147302,0.11266828,0.05762862,-0.019216912,0.03299726,-0.009978962,0.06765515,0.07896673,0.059868585,-0.034177452,0.014211709,-0.1203867,-0.040106956,-0.092854634,-0.0032407623,0.006839283,0.02137837,-0.03352548,-0.048926335,0.004096981,-0.011692025,-0.009739921,0.030500753,0.013067638,0.018721992,0.077915795,-0.0014675651,-0.075986594,-0.025460256,-0.028328173,-0.035408538,-0.042585842,-0.0035593715,0.09402838,0.13992853,-0.07176767,-0.08381498,-0.012385347,-0.020290678,0.022703456,0.06896513,0.024590304,-0.06072985,0.0053983787,-0.06405034,2.0994988e-33,-0.010756102,0.0782255,0.015195164,-0.060271047,0.051253542,0.007319447,-0.0727448,-0.031996712,0.061493207,-0.055430334,-0.053810753,-0.04156781,0.023841092,0.039993264,-0.0011778938,-0.02449582,0.006184809,0.022494461,-0.048377562,0.012210629,0.0239498,0.012738215,-0.015181513,-0.01767552,0.030379144,0.022374593,-0.007824594,0.082024485,0.13722542,-0.025208717,-0.020534195,-0.021575099,-0.044852715,-0.0061103133,0.027336782,-0.0045092753,-0.08227865,-0.015110043,0.1118232,0.046134915,-0.023809582,-0.012463243,-0.05135861,-0.004603487,0.066609144,-0.012542993,-0.029970298,0.08488569,-0.019632742,-0.0015524835,0.10086813,-0.068399675,0.056463875,-0.05373937,-0.040044222,0.017742978,-0.03310533,0.040179413,0.047046375,0.07039424,0.0010003108,-0.047667254,0.026897173,0.013783506,0.023733713,-0.00036822457,-0.042570382,-0.018531932,-0.046897188,0.042875927,-0.07230432,0.023070054,0.025631845,0.03745324,-0.0008015775,-0.0008401046,-0.08780594,-0.021185493,0.067017384,-0.022875637,-0.039300136,-0.040482897,-0.05877803,-0.011115913,0.0062552816,0.04621061,-0.020286812,-0.1235985,0.017817615,0.075861484,-0.04541513,-0.08992288,-0.08189595,0.006862664,0.03361092,-4.940512e-33,0.11332256,-0.06967475,0.04687551,-0.06666661,-0.030514391,0.10317288,0.007709978,-0.050067544,0.039772335,-0.021915406,0.07073512,0.018761434,-0.05858112,-0.09290511,-0.061072968,-0.038471185,0.0066419845,0.07118645,-0.021970026,0.07269029,0.025566984,0.006779896,-0.031013303,-0.010254089,0.032394428,0.05456982,-0.03123659,0.04123485,0.01977698,0.08514925,0.0164133,-0.027526738,-0.02208404,-0.0751452,0.002962355,0.076688446,-0.08426395,0.029483743,-0.01620254,-0.04998808,0.033407655,0.016645018,-0.011414298,0.085361026,0.02656042,0.015970258,-0.049019206,-0.0017609211,0.014981751,-0.07863404,0.0306524,-0.022008136,0.027897695,0.042433202,-0.027605614,0.017840996,0.021062877,-0.0094505,0.07431018,-0.022410471,-0.04540668,-0.025468323,0.0018892852,0.003997227,0.042839594,-0.025120672,-0.030393595,0.039426517,0.03407483,-0.02530604,0.0065692877,-0.01909209,0.024846299,0.06676571,0.012192528,0.042962264,-0.06822462,-0.06499074,-0.005668117,0.032211963,-0.012609317,0.028582666,-0.040359654,0.00029401958,-0.01570083,-0.057711117,0.07330495,0.016156444,0.0054763313,0.032540374,0.010191027,0.034466516,-0.006756384,0.012018067,0.036111075,-4.5056574e-08,0.108132154,-0.0038170018,0.06429383,-0.03718472,0.038618356,-0.054007716,-0.07224123,-0.06280487,0.009236977,-0.039443754,-0.03612845,0.09266072,0.020962477,-0.030399898,-0.049932763,0.008227555,-0.06849034,0.009106774,0.03618757,-0.011828877,-0.10885115,0.0007126933,-0.062061094,0.0314671,0.09491097,-0.013451754,-0.015749717,-0.00071727956,-0.0075118523,0.00039271018,0.07320873,-0.02185475,-0.0135630835,-0.04109274,-0.04555468,-0.022441717,-0.078788005,-0.057260167,0.027017402,-0.0120634865,0.064999916,-0.028166944,-0.051253248,0.0017709697,-0.027016934,0.038318958,-0.021469079,-0.019411178,-0.057722423,0.011520828,0.053975437,0.015020276,-0.0049960753,-0.005072638,-0.07837975,0.053101383,-0.015559383,-0.0658528,-0.0790244,-0.07617663,-0.04095516,-0.017927164,0.19804542,-0.05323677 +3.5.1.113,"Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 3.5.1.112, 2'-N-acetylparomamine deacetylase.",384,0.99999994,-0.01814863,-0.025139371,-0.13020508,-0.025958285,-0.017744647,0.015755894,-0.073331766,0.033800043,0.060460944,-0.022077974,-0.02968448,-0.0013344989,0.10129353,0.032000013,-0.015451676,-0.015917452,-0.087224156,-0.03316665,0.01567294,-0.050328255,0.08669694,0.062982984,0.041162413,0.008622132,0.06610121,0.0057046106,0.009320536,0.01680099,-0.06533604,-0.056550186,0.09156288,-0.06263088,0.024763225,-0.038955323,0.114803895,0.0570126,-0.06595405,-0.044396598,0.14566272,0.07147725,-0.051895626,-0.00199246,-0.013389582,0.0034692432,-0.020082826,-0.016930271,-0.02447479,0.036217544,0.044703003,-0.024682283,-0.052536443,-0.043734606,-0.03362251,0.047881488,0.08321621,0.08196539,0.004381884,-0.08161656,-0.013809328,-0.023919322,0.08944762,0.005678775,-0.015075259,-0.022830931,-0.11164491,-0.037956726,0.05396619,-0.11738502,0.06437126,-0.0003722494,-0.102353156,-0.071506985,0.002459774,0.03637261,0.018603409,-0.037846997,0.011724777,-0.010816598,-0.07465157,-0.060482536,0.038534414,-0.035246976,0.011296226,0.08685579,0.048628233,-0.0065625,0.05355751,-0.015003648,0.075422004,0.056214657,0.043430753,-0.05532148,0.0025424801,-0.055984825,-0.038336262,-0.06723173,0.019216852,0.04415225,0.047497775,-0.011861581,-0.003522092,0.030475477,-0.05439988,-0.026194425,0.02469027,0.03324604,0.048573714,0.13197097,-0.015490167,-0.023287904,-0.024204636,-0.067018375,0.01474266,-0.0005986541,-0.053657033,0.12601165,0.12134841,-0.06103949,-0.072853476,-0.024740225,0.034568287,0.039124314,0.02388004,0.042955246,-0.038713925,0.06321665,-0.117165916,2.6039248e-33,0.005380046,0.08880655,0.0017108284,-0.05257322,0.038942073,0.012185774,-0.1158761,-0.016653568,0.051379256,-0.056488384,-0.04980389,-0.030813517,0.034447897,0.063994996,-0.04517859,-0.027504819,-0.007482447,0.05015197,-0.029069161,-0.0046124877,0.0057655107,0.007902636,-0.019589206,0.016578022,0.014890773,0.06447858,-0.052494362,0.08341648,0.10083982,-0.01990195,-0.03285977,-0.02998203,-0.066079624,-0.008476606,0.036957595,-0.026754659,-0.023050763,-0.038851094,0.099885024,0.07302963,-0.01818235,0.038753517,0.010901295,-0.026953006,0.0407193,0.0054128785,-0.07819,0.089301415,0.05748097,0.0011876891,0.04682776,-0.0464743,0.09572288,6.8868234e-05,-0.04142168,0.02024935,-0.010067998,0.03868624,0.045291808,0.045851797,0.021090971,-0.011493312,0.045357667,0.01530042,0.02361003,0.021365158,-0.015369501,0.016757542,-0.013026746,0.053640816,-0.11774537,0.046662804,0.074062474,0.026097214,0.038705006,-0.029956259,-0.09360877,-0.04799588,0.002567861,0.02707251,-0.045480613,-0.021152329,-0.052543975,-0.03360682,0.010164063,0.021409657,-0.018237012,-0.06112031,0.017259294,0.065734245,-0.085451655,-0.101491846,-0.098010145,0.020112175,0.018089587,-4.4409886e-33,0.106785305,-0.03351149,0.036286704,-0.061054103,-0.034316514,0.06089171,-0.034396738,-0.007957429,0.019108241,0.0038039184,0.062441837,0.022303125,-0.004224376,-0.071126625,0.0038628944,-0.04489458,0.015365949,0.07730466,-0.029030384,0.031070687,0.03717709,0.019539537,-0.08405419,-0.0043155034,0.044910498,0.024056539,-0.041073244,0.068537794,0.010697747,0.049159296,-0.016001528,-0.043105196,-0.054190163,-0.083358444,-0.012383603,0.13285662,-0.04754479,0.02409824,0.0072484333,-0.031509366,0.02589715,0.01610549,-0.0010116932,0.0991743,0.0460658,0.031547006,-0.07254767,0.01910762,0.0017703151,-0.03812254,0.014095107,0.01481939,0.029855685,0.025599271,-0.016335795,-0.0011375139,0.020929914,0.01994123,0.042787317,-0.014135894,-0.03070747,0.008089861,-0.003656492,0.001012778,0.022182908,-0.021952529,-0.08734803,0.061906345,0.108831525,0.023391807,0.012721514,-0.01638114,-0.016383065,0.053538654,0.013417058,0.039560325,-0.10601483,-0.0714649,-0.006004741,0.007965444,0.0088515,0.0015810084,0.02467205,-0.036144286,-0.06486139,-0.03450945,0.058745973,0.047579233,-0.024415206,-0.0062202206,0.014854685,-0.038996935,-0.0058123665,0.046485633,-0.01406246,-3.332484e-08,0.0936387,-0.0005728771,0.07952229,-0.005342892,0.040582,-0.006123251,-0.048491385,-0.032880664,0.0066350377,-0.061496835,-0.022921057,0.068358354,0.01349459,-0.0033025807,-0.05931838,0.01742321,-0.057229802,0.0145123545,0.008970783,-0.0034082476,-0.07429501,-0.00035947448,-0.10151004,0.027672404,0.073538266,-0.0304357,-0.0064061773,5.0821007e-05,-0.057519693,0.0012650407,0.06620564,-0.016497403,-0.028374694,-0.016928207,-0.05119592,-0.04539672,-0.066424474,-0.0639845,0.0326894,-0.042989165,0.06498247,-0.029402928,-0.07301826,-0.00026146416,-0.07818788,0.049234852,-0.028000595,-0.048291918,-0.055148125,0.004793123,0.048261955,-0.0040344484,-0.02942648,-0.009064439,-0.110341795,-0.014952118,-0.041958205,-0.045779392,-0.035150446,-0.049978692,-0.04124295,-0.012347087,0.21765302,-0.0658263 +3.6.1.63,Isolated from the bacterium Escherichia coli.,384,1.0,-0.07909442,-0.02448093,-0.114510484,0.041953772,0.017848171,0.03926226,-0.027097216,0.06519545,0.043959063,-0.04552074,0.08314315,-0.038169194,-0.006173411,0.04109008,-0.027136778,-0.042954918,0.03230206,-0.0015897375,0.009218124,-0.029983819,0.031393986,0.11901161,-0.021579113,-0.029717384,-0.031747717,0.046222813,0.07444686,0.010929896,0.016175045,-0.07881615,-0.01229077,-0.06601076,0.048521634,-0.079462305,0.1404767,0.042580623,-0.0060372776,-0.047056243,0.18468918,-0.027205441,-0.057778865,0.033794507,0.061454315,-0.034682356,0.022445869,0.023847895,-0.014220077,0.062489003,0.077773,-0.06750922,-0.023691852,-0.014543173,-0.017475195,0.047346957,0.06040526,-0.025574818,0.012454542,-0.09969409,0.0015510124,0.050605435,0.056233592,0.027208045,0.04228029,0.03487901,-0.05562999,-0.063895084,0.032295015,-0.0031827756,0.08672793,-0.07005111,-0.008105803,0.0178591,0.06916732,0.09602672,-0.047443643,-0.040391978,0.026908183,-0.017676733,0.05400527,0.07874454,0.022199115,-0.05324752,0.034964107,0.07757862,-0.02692293,-0.033427123,0.040181533,0.09663872,0.021851012,0.044914696,-0.04952181,0.024279723,0.03011045,-0.08049242,-0.027118396,-0.055419296,0.008951629,-0.011206515,0.04431301,0.019425653,-0.024576027,0.023365825,0.06603167,-0.08100541,-0.07438733,-0.01888881,0.015349642,0.03344319,0.046409607,-0.00015219345,-0.017677808,0.047749083,-0.045810007,-0.059251774,-0.001704984,-0.024729885,0.12100084,-0.05390708,-0.032748174,0.037127465,-0.0097377505,-0.05778811,0.09205018,0.012245072,-0.03978878,0.022940824,-0.05016902,-1.1541489e-33,0.008950131,-0.016467746,0.05153162,-0.010173946,0.04766623,-0.014493455,0.0076248473,-0.070738085,-0.072730765,-0.0072501507,-0.060537502,-0.07525238,0.00049968646,0.0035611868,0.02270296,0.028404107,-0.024801746,-0.00209136,0.020636406,-0.06757562,-0.012389792,0.07925631,0.045975443,-0.025907485,-0.017712828,-0.021993434,-0.05293795,-0.03038245,0.040858295,0.0064336895,0.023395414,-0.038638856,-0.06986162,-0.022990154,0.08381779,-0.011565861,-0.09954448,-0.04679874,-0.008540554,0.07348936,0.084886074,0.0661537,0.05557674,-0.010210157,0.059814177,0.034149144,-0.07680249,0.028833685,0.05824411,0.000687618,-0.019052012,-0.013221276,-0.011997416,-0.06919642,-0.079392895,-0.03528781,0.018407827,0.043077007,0.026320426,0.039521348,-0.0027314448,0.16130789,-0.07807034,0.042630825,0.037578817,0.020525122,-0.050965518,-0.023214392,-0.07232932,0.0449864,-0.024955276,-0.042893685,0.03187883,-0.08055885,0.0034331242,-0.04521096,-0.05884602,-0.0055004046,0.014460065,-0.06865058,-0.050354607,-0.007836776,0.004808921,0.026391082,-0.0771912,0.08490451,-0.05117045,0.064515,-0.0050343727,0.081551924,0.020674827,-0.044124495,-0.08732109,0.023904698,-0.04118846,-1.4545046e-33,0.077663094,-0.024712553,0.0076767164,-0.09036549,-0.061207473,0.10041089,-0.053526253,0.053976025,0.00046998987,0.04655402,0.004558951,0.048561037,0.082404524,-0.051432874,0.04332525,0.067465,0.07012102,0.08247932,-0.073242836,0.008839442,0.0008278202,-0.04598901,-0.0033469577,-0.079986826,0.013837954,0.054334957,0.027871944,0.049068604,-0.025805157,-0.0059154285,-0.0012759538,-0.040391136,-0.060774703,-0.11330849,-0.100243226,0.025709178,-0.05956129,-0.087938905,0.038183782,-0.052524514,-0.029338107,0.08105271,-0.04670054,0.071121566,0.005426919,0.061188642,0.02601788,-0.0026911031,-0.016780308,0.041451532,-0.028168457,-0.06305295,0.0072477446,-0.095598765,-0.019903827,-0.056318004,-0.036048535,0.06737809,-0.025193483,-0.01947666,0.042661548,-0.004135351,-0.041248072,0.006439566,0.06060104,0.100968,0.0040517184,0.042852815,-0.05139464,-0.078822814,0.025424741,0.04204094,-0.023067836,-0.0013929117,0.011702029,0.022255974,-0.09584443,-0.066309,0.024452347,0.029749947,0.04272574,-0.056387056,-0.022342106,-0.010169663,0.058836214,-0.08122202,0.04593934,-0.033315405,0.06825669,-0.008488028,-0.019270785,0.017927581,-0.052265663,0.0062406184,0.040483505,-1.9371914e-08,0.058250003,-0.07516481,-0.0008629088,-0.0006708294,-0.010887484,0.039770648,-0.016865285,-0.003919416,0.06089332,0.05141354,-0.012026404,0.004459893,-0.015383217,0.042418122,-0.0014857599,0.016691113,-0.042454656,-0.011140986,0.008938356,-0.004404264,-0.065405056,0.0036871096,0.030326212,-0.005333561,0.0067746225,-0.052430984,0.06901451,-0.07615917,0.0015696719,-0.047876757,-0.06951545,0.020552697,-0.059059527,-0.022806445,-0.06548809,-0.0071677295,-0.03541757,0.010319132,-0.051917724,0.024896901,0.036495455,0.016409919,-0.07724267,0.030313589,-0.035396647,0.036691636,-0.04680331,0.030938033,-0.06900379,-0.085089155,0.0468344,-0.0134332,0.050763994,0.030187305,-0.11004082,-0.0022892763,0.011755509,-0.1010746,-0.022628453,-0.01665104,-0.030850846,-0.013698407,0.14737655,0.09931997 +3.7.1.20,"The enzyme is involved in bacterial degradation of 5-substituted salicylates, including gentisate (5-hydroxysalicylate), 5-nitrosalicylate and 5-halosalicylates.",384,1.0,-0.025044072,-0.060869843,0.014020119,0.028177101,0.09930808,0.040227335,-0.05130735,0.00741645,0.029121466,-0.04064373,-0.015073642,0.047029145,-0.010012617,0.0663251,-0.05365493,0.08064796,-0.09187418,0.027737446,-0.024135454,-0.014647523,0.06878377,0.011541701,-0.06347787,-0.017973168,0.03947859,0.0036215088,0.06561921,-0.032637663,-0.047515884,-0.06254646,0.02238331,0.06237934,0.11082707,-0.057525083,0.06572811,0.12643045,-0.0044588693,-0.102735095,0.052563284,0.018811956,0.0073650316,-0.0074295723,-0.023171974,0.012275357,0.015457451,0.0008453123,-0.0005509654,0.010036226,0.07474595,-0.030903079,-0.09764307,-0.06303622,0.0062927627,-0.04000242,-0.032867294,-0.037688747,-0.05379403,-0.10953505,-0.037585437,-0.015911235,0.056764767,0.013669873,-0.019576857,-0.09025163,-0.03278436,-0.01915712,0.07240535,-0.12799926,0.020827873,0.0014293602,-0.14923555,-0.086564705,0.022776688,0.054360725,0.006125152,0.010251993,0.03261172,-0.08959022,0.00020370424,-0.060170155,0.00018889779,0.0360331,0.013242127,0.03492968,0.035039365,0.022139143,0.08353734,-0.023399165,0.07193622,-0.02422591,-0.047219273,-0.029590512,0.03421282,-0.059134953,-0.05744274,-0.009248369,-0.10116625,-0.022397006,0.041996248,0.001680998,0.011432907,0.0066241324,-0.019612683,-0.063011244,-0.051996235,0.018511135,-0.009541701,0.06890202,-0.009256131,-0.0074593183,0.00754417,0.049971197,0.0030712073,0.02316709,-0.008198456,0.064762644,0.013580173,-0.023312159,-0.06448061,0.028514123,0.00044626693,-0.068724595,0.0596635,0.037361108,-0.10675512,0.112430334,-0.036924556,1.9122103e-33,-0.03060927,-0.0101213185,-0.0033013034,0.0042656083,-0.043929163,-0.06094719,-0.027154703,0.014540609,0.008235302,-0.1088418,-0.006690482,-0.006113047,0.017796174,-0.034332115,0.057918712,-0.020873973,0.017787794,0.05070476,0.024063151,0.046628878,-0.0649333,0.11232477,0.026658613,-0.015756544,0.04910577,0.03315111,0.031359535,-0.01002158,0.08601668,-0.037576396,0.037700985,-0.060198896,-0.037431248,-0.0072433804,0.057848305,0.056187846,0.0043722116,0.026271822,0.031786036,0.066148855,-0.018459363,0.10212331,0.000923221,0.048991285,0.019049825,-0.018726427,-0.048653115,0.14423995,0.016517147,-0.011277663,-0.013786262,0.019250171,0.040770225,-0.01668661,-0.022137642,0.021484032,0.012337528,-0.0013239472,-0.00653992,-0.03528677,-0.0002669406,-0.008488526,-0.005231106,-0.044345047,0.020745121,0.03302634,0.0013690633,0.029538363,0.08852725,0.0850133,-0.043583013,0.026575046,0.016639048,0.1315191,-0.025836805,-0.08511157,-0.03833195,0.082763456,0.10089971,0.0054264064,-0.010539947,0.036046524,-0.0070402706,0.035620064,-0.05404825,0.012544286,-0.014847659,0.011895839,-0.02006418,0.034880348,0.03800266,-0.1002428,-0.00909361,0.019353976,-0.055588063,-2.7224317e-33,0.0547936,-0.096024945,-0.04684419,0.03227587,-0.118899025,0.008882737,-0.039630994,0.036773916,-0.08465332,-0.023388864,0.03729438,0.017110078,0.07198099,-0.026864827,-0.021626232,-0.0070482297,0.03049481,0.017263832,-0.108234785,-0.016862921,0.009659155,0.0982098,0.077427916,-0.041521233,0.025340248,0.066023424,-0.0033885501,0.030865915,0.06460436,0.016489098,0.03132112,0.033531643,-0.033969443,-0.08997351,0.010900345,0.0278586,-0.026953664,0.018104922,-0.03381345,-0.022089638,0.033496257,0.080824256,0.040107857,0.063995264,-0.01708139,0.06830038,-0.058434412,0.06613662,0.011462367,-0.06746966,-0.017902685,-0.05090576,-0.033115685,-0.052196227,-0.09078153,0.01584017,0.06944753,-0.020245459,-0.0470164,-0.046886623,-0.07184104,-0.043968596,0.098569885,-0.0076270215,0.035496876,0.052171037,0.034245823,0.046421748,0.036773812,-0.09047287,0.0309977,0.044999577,0.080283344,0.017964847,-0.028998705,0.013254776,-0.090699285,0.008825875,0.037033107,-0.032802187,-0.01823814,-0.04485827,-0.074564785,-0.03698318,-0.059113137,-0.05953486,0.08912966,0.104264915,0.059876744,0.032422125,0.030727137,-0.04173685,-0.08630721,-0.0145127885,0.034154736,-3.0102917e-08,0.08507971,-0.09053266,0.019539172,-0.040494792,-0.05547997,0.01977996,-0.03497524,0.037479296,0.11315999,0.0017655763,-0.03337707,0.08172137,-0.022202674,0.007172861,-0.03844098,0.023593776,-0.004086985,0.013433773,-0.021261506,-0.014583652,-0.114899345,0.012986173,-0.0046448153,0.07894887,0.044593472,-0.074584454,0.0823886,-0.012281203,-0.03479511,-0.071950026,0.00905145,0.043374967,-0.009240161,-0.004450575,-0.0120248925,0.0390401,0.007105657,-0.03551221,0.0045846365,0.08622694,-0.008340999,-0.031866256,-0.09888229,0.013803236,0.017665308,-0.008863002,-0.0040047783,0.016393818,-0.033279765,-0.028131042,-0.009790707,-0.038470924,-0.053011775,-0.0366016,-0.11846932,-0.0010174059,0.028825281,-0.09480471,0.033874113,-0.04826298,-0.0137672145,0.034457725,0.14772838,-0.024271399 +4.2.1.135,"Contains NAD+ as a cofactor [2]. This is the first enzyme in the biosynthetic pathway of N,N'-diacetylbacillosamine [1], the first carbohydrate in the glycoprotein N-linked heptasaccharide in Campylobacter jejuni. This enzyme belongs to the short-chain dehydrogenase/reductase family of enzymes. ",384,1.0,-0.037554942,0.0038137014,-0.1575669,-0.025575934,-0.002812304,0.073480494,-0.056227688,-0.004065021,0.024308925,-0.030221673,-0.011709257,-0.020461544,-0.066525295,0.012863084,-0.030973213,-0.039459422,0.009068787,-0.035162464,0.0068467907,-0.081591874,0.033495978,0.04795088,0.01644609,-0.059380334,0.08223735,-0.035169814,0.06683248,-0.04211388,-0.009748347,-0.06319791,-0.010308739,-0.08307919,0.010725901,-0.062178437,0.060932785,0.0410258,-0.0073426072,-0.021383496,0.07711919,0.04376367,0.031458404,0.02510784,-0.0010061051,-0.004175532,-0.018746994,-0.040541735,0.0029250772,0.084510975,0.066886134,-0.03240242,-0.069699995,-0.058096115,-0.005396323,0.012424434,0.08176678,0.04140006,-0.024901291,-0.02495805,-0.0047029755,0.031326227,0.039460372,-0.007648134,0.054759968,-0.03514974,0.0617827,-0.07427797,0.055876702,-0.06810086,0.004700653,-0.038148936,-0.0901613,-0.020482445,0.011655034,0.004033601,-0.043394465,0.016615484,-0.06814984,0.08550547,0.075667955,-0.06501508,0.03452762,0.015717285,0.058126397,0.0946762,-0.028249022,0.0052359826,-0.021592963,0.03074701,0.049870405,0.017688653,-0.0036477845,-0.05073105,-0.020135818,0.014956061,-0.109936066,-0.049873933,0.058739215,0.041779812,0.017807405,-0.056064084,0.035006795,0.04592582,0.07651521,0.0049145347,-0.13293704,0.058781195,0.04605778,0.12829036,0.014089013,0.0108194845,-0.066783994,0.0735962,0.036146767,-0.030322554,-0.10440487,0.04873363,-0.024106843,-0.05001975,-0.03276305,0.0014719634,0.05204915,-0.02050007,0.06302744,0.036504805,0.00076024927,0.03380178,-0.11409172,4.1299572e-33,0.07958595,0.026765898,0.08238015,-0.021624666,0.04051078,-0.017074708,-0.1096701,-0.00059811503,-0.015604726,-0.04134786,-0.03171046,-0.0760903,0.017692568,0.022350032,-0.05877182,0.024806602,-0.09401852,-0.07119117,-0.0030103833,-0.012062326,-0.04237292,0.062384494,-0.009338186,-0.01793996,0.027874311,0.011701215,-0.0052949497,0.01566769,-0.012990618,0.016798265,0.020923583,-0.102024995,-0.09371304,0.012559269,0.08335721,-0.05603499,0.0018154414,-0.026688376,-0.02472326,0.02339783,-0.042599592,0.06829613,0.00014985901,-0.04975948,-0.016662117,-0.07859183,-0.017456502,0.10196586,0.04315434,0.08782534,0.02716978,-0.042288907,0.091560185,0.011079692,-0.06257273,0.084560804,-0.016235424,-0.0086872345,0.010082868,0.103469305,0.018320903,0.03827041,-0.031464573,0.01329459,-0.008107066,-0.00027121443,-0.061849523,-0.02596386,0.08286759,0.0009993431,-0.041369177,0.007995191,0.06803173,0.081419125,-0.002230593,-0.07072225,0.019038077,0.00871335,0.0009786608,-0.037582852,0.01707116,0.008640832,-0.007919016,-0.053176094,-0.040248577,0.05950713,-0.029698027,-0.11742915,-0.06878274,0.05649123,0.014329486,-0.021985903,-0.02382353,-0.018858992,0.07496848,-4.7255178e-33,0.096708365,-0.055934824,0.0733335,-0.07565916,-0.00955637,-0.009503717,0.034907565,-0.086429976,0.026240312,-0.03650629,0.04118246,0.0752224,0.077552326,-0.043862015,0.064009294,0.032776915,-0.030629586,0.10369537,0.022258367,-0.047055777,0.022574896,0.0641836,-0.014906333,-0.07567526,0.006779601,-0.015843662,-0.037882853,0.115491316,0.03829663,0.01888717,0.032949753,-0.00080767606,-0.064542584,-0.06688053,0.0028856935,-0.013265973,-0.06853667,-0.030773677,0.006021659,-0.035501152,0.026426954,0.041341692,-0.01871703,0.020425426,0.058666237,0.020235902,-0.116603374,-0.003117393,-0.0027179488,-0.03231007,0.0017868102,-0.010474404,-0.036256738,0.051979102,0.07619174,0.07122187,0.06770377,0.07611983,0.03913934,0.01597906,-0.007925111,0.008115265,0.041019857,0.018217916,0.061625186,-0.046597086,-0.010712673,0.04836403,0.103685394,0.020060008,0.044281915,0.008437463,-0.036362216,0.07476838,-0.0533132,-0.023560008,-0.06906069,0.018932452,-0.043668136,-0.014195448,0.03233832,-0.028049558,-0.030446531,-0.09316623,0.035616912,0.006560178,0.06778942,0.11909117,0.02537282,0.055522006,-0.010137143,-0.06783906,-0.043666054,0.08512421,-0.032780997,-3.8036085e-08,0.020438712,-0.0965121,0.01017278,-0.073553406,0.0019127998,0.047304366,-0.0026876724,-0.039687566,-0.036660653,-0.026074415,0.050745327,0.08136177,0.0016225692,0.032018762,-0.051157422,0.03910826,-0.032986917,-0.004139003,-0.036486477,0.02627775,-0.076063,0.013937493,-0.09042175,0.04782144,0.019723732,-0.06926551,0.00602827,0.04428283,0.03047273,-0.028363613,-0.00052476465,0.08350318,0.046952203,-0.12614363,-0.0967444,0.018174414,-0.009349855,0.03621927,0.015044438,-0.015554278,0.02698564,-0.040099766,-0.004401129,-0.007913885,0.006856851,0.06046404,-0.024688356,0.002050533,-0.107027836,0.0011837356,-0.027334573,-0.015849948,-0.039156627,-0.03418105,-0.11260049,0.031269316,-0.035076953,-0.0013911168,0.022699466,-0.0626489,-0.018482894,0.025465375,0.14702933,-0.04983699 +4.2.1.136,"Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers. The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC 5.1.99.6), while the other catalyses the dehydration. Hence the enzyme can restore the complete mixture of isomers into NAD(P)H. The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC 4.2.1.93, ATP-dependent NAD(P)H-hydrate dehydratase).",384,0.99999994,-0.050769795,-0.034989886,0.0066348473,-0.03938456,0.035647914,0.06731661,-0.018117987,-0.015059992,0.042035095,0.0067658443,0.0012987307,0.012321685,-0.06499372,0.07022274,-0.0112147415,-0.06033368,-0.043669216,0.028382666,0.03130593,0.019210843,0.10336978,-0.028555645,0.012015731,-0.03819645,0.0541874,0.053314615,0.102700084,0.023415403,-0.001678401,-0.08245993,-0.09484368,-0.06910482,-0.006463007,-0.08718739,0.017874256,0.15286744,-0.041057684,0.015989793,0.008486016,-0.004210675,0.037216067,-0.030391857,-0.04687031,0.00014415874,-0.026853062,-0.038277235,0.008032424,0.11751282,0.03392177,0.0012676913,-0.023736637,-0.015797744,-0.0057885093,-0.01247262,-0.0043724654,0.04835929,0.005112511,0.014239699,-0.049970012,-0.17143711,0.006360188,-0.061954986,-0.014411834,0.065986104,0.065551236,-0.05638522,0.075891405,0.022818007,0.0034112972,-0.06564389,-0.14205886,0.011399841,0.037267376,0.02365189,-0.038298547,0.01137702,-0.078131795,-0.036843795,0.017130915,0.01326407,0.03478039,-0.028410416,0.0065110987,0.08163119,0.03154092,-0.045561124,0.02227221,0.0076838946,0.03365316,-0.0475069,0.00036960808,0.012752631,-0.042434186,-0.022958523,-0.1627576,0.0019726562,0.044400174,0.070017435,0.042789202,-0.047509033,0.03690105,0.12543154,-0.036301605,-0.07442771,0.084539495,0.060419586,-0.027603075,0.1411322,0.027442934,0.058436565,-0.09720463,-0.029825,0.059130974,0.013309308,-0.027172172,0.037482962,-0.041596163,-0.0041680364,-0.12280842,-0.025320532,-0.03358758,-0.0068232296,0.09357261,0.005278909,0.010671262,0.033003636,-0.09941679,2.9111563e-34,0.044913173,-0.051417697,0.02321883,-0.00091222854,0.013283882,0.016157428,-0.05250722,0.03009104,-0.05889829,-0.03245778,-0.05878637,-0.07255677,0.059991896,-0.012779542,0.030379226,0.045287088,-0.018742068,0.0078873485,-0.0031131501,0.01348097,0.068372324,0.10640251,0.0044037807,-0.014924157,-0.011092432,0.0012557626,0.02778626,0.07720385,0.018960334,-0.018097041,0.015372527,-0.11260141,-0.036974363,0.013835838,0.10334083,0.015203625,-0.053267445,0.0011776938,-0.011590386,0.00071459956,-0.03629365,0.038700968,0.021866517,-0.1050225,0.028999278,-0.11006379,0.01989421,0.055259112,0.016857427,0.013092037,0.051389053,-0.032331754,0.070974864,-0.020097462,-0.05671327,-0.011070046,0.0025542318,0.019641543,-0.036606055,0.08889131,0.03619457,0.045194022,-0.025416791,0.039940413,-0.04735281,0.034926485,-0.074078895,-0.03502004,0.029594317,0.090441026,-0.058154408,0.053650334,0.047087062,0.05292461,-0.006978977,-0.023427784,0.037188016,-0.050861146,0.021097755,-0.012918883,-0.004910139,-0.041129515,0.02543707,0.038337708,-0.04512947,0.014043945,-0.004934843,-0.05631618,0.0386158,0.04430835,0.0945877,-0.053837866,-0.060591716,-0.054255772,0.04715699,-2.46395e-33,0.15599322,-0.00061017025,0.06803433,-0.100558765,-0.011663225,0.121565625,0.027065316,-0.015361774,0.004258461,-0.10178231,0.032460283,0.03521656,-0.029129801,-0.043718215,0.015224506,0.032842953,-0.0018601002,0.05571697,-0.02035383,-0.02622605,0.016274549,0.07021497,6.1713974e-05,-0.005659597,0.03230308,-0.03764434,0.045703106,0.046183627,0.024015237,0.056422483,0.014533874,-0.018565154,-0.05996129,-0.011303018,-0.0082767345,0.018124526,-0.07652354,-0.024895733,-0.02440507,0.052431107,0.043123476,-0.040551666,-0.020595754,-0.061430007,0.066524826,0.016871357,-0.055118836,-0.08157079,-0.045494862,-0.045709122,0.08130917,-0.060409516,-0.025251467,0.05126536,0.07136107,-0.0048788595,0.0006665609,0.0044792066,0.007531982,0.03148693,0.005073142,-0.018759973,0.014037184,-0.0017580338,-0.026633084,-0.020679597,-0.01949228,0.05771629,-0.019349705,-0.0189585,0.04576311,-0.00967183,0.0067020003,0.038992442,0.08173446,0.0021517032,-0.05321047,-0.011345291,-0.036413647,-0.037510242,-0.052660383,0.06404057,-0.08142807,-0.07783279,0.013440831,-0.007835076,0.044675633,-0.021546813,-0.023688372,0.055646222,0.025559718,-0.01661171,0.013247582,0.05938765,0.047685098,-4.2199126e-08,-0.0037037542,0.0010847207,0.050989557,-0.008222501,-0.05965659,0.04794649,0.038765885,-0.022377377,0.026235193,-0.016304852,0.01869033,0.082750686,0.048098028,-0.0037208518,0.003148608,-0.027308127,-0.059703503,0.017909333,-0.078048676,-0.0813413,-0.08971249,-0.043858666,-0.1154981,0.077098526,0.08202379,-0.020739082,-0.0015126378,-0.012708764,0.0032703062,-0.10316598,0.0054536243,-0.007368993,0.021431085,-0.032970577,0.018169114,0.06344631,-0.023139773,0.013710213,-0.07355006,0.06444805,0.057491485,-0.09074927,-0.061395276,0.008809786,0.079063945,0.055053245,-0.007898268,0.037400384,-0.06264196,-0.013535235,0.031534575,0.020680914,-0.026208734,-0.09334802,-0.048822,0.056479853,-0.017095309,-0.07471939,-0.021858871,-0.041371234,0.116178095,-0.024253156,0.09359516,-0.057867166 +4.2.1.137,The reaction occurs in the reverse direction. Isolated from Bacillus subtilis. Similar sesquarterpenoids are present in a number of Bacillus species.,384,1.0,-0.025263814,-0.05879425,-0.025067996,0.030889468,-0.078062646,0.013726401,-0.08860427,0.049619243,0.07552418,-0.032264624,0.0989039,-0.06421545,0.07149307,-0.027497312,-0.074278094,0.0068323826,0.03487586,-0.016742695,0.019628847,0.01223769,0.0525208,0.05853645,-0.06174638,0.015778584,0.03559509,0.011284466,0.03814117,-0.03320822,0.039361745,-0.052850503,-0.025001686,0.012922756,0.04255512,-0.09324999,0.020564493,0.035811856,-0.053600162,0.015915804,0.14625072,0.025609402,-0.0026158313,-0.023677062,0.0101458235,-0.10936423,-0.046035606,0.018309824,-0.033878107,0.030648416,0.027072342,0.020059705,0.003770362,-0.021144982,-0.117693536,0.06363166,0.01969176,-0.048158426,-0.004569421,-0.00731792,0.0070963246,0.033451814,0.07927439,-0.030007388,0.03444885,-0.038211063,-0.03000882,-0.012663285,0.0053631845,0.0052104844,0.0345769,-0.030813344,-0.0067565613,-0.025974339,-0.020617515,-0.0063070185,-0.031173095,0.028676705,-0.00039173785,-0.007498141,-0.008059189,-0.050222144,0.055443358,-0.016384898,0.02444475,0.11570591,0.029714866,0.017034648,0.00058740005,-0.018977566,0.038876437,0.079696506,-0.0019098154,0.04897412,0.030706253,-0.08907139,-0.01766129,-0.018407738,-0.01500026,0.06749974,0.045064703,-0.02867438,0.017418375,0.041829515,-0.044511437,-0.04905268,-0.038595412,0.011290215,-0.040202778,-0.062999845,0.054546814,-0.024648705,0.03482619,0.018274115,0.052040484,-0.07764066,-0.005567189,0.03567101,0.075186566,-0.03204222,-0.04357256,-0.058082208,0.013321184,-0.004121771,0.016742637,-0.020176137,-0.0058550383,0.015097424,-0.042635046,1.8282675e-33,0.032329913,0.014131581,0.049427353,0.0036536478,-0.014623758,-0.06188419,-0.0412524,0.03306325,-0.083199404,-0.06087136,-0.07340135,-0.06287171,0.005045352,0.051467944,-0.05065533,0.002362447,0.06576424,0.018878197,0.019631226,-0.119924545,0.018989619,0.037552994,-0.028256549,-0.05524436,0.019031834,-0.008066874,0.031083541,-0.0042554243,0.017568095,-0.044956435,0.090048626,-0.016440358,-0.074510366,-0.02260748,0.10024043,0.0030588268,0.0068834773,0.017553337,-0.08554356,0.027516782,-0.029544646,0.08677605,-0.05903029,-0.054355834,0.11789281,0.021357778,-0.02343564,0.026271917,0.12413168,0.0020597163,-0.021854836,0.025130978,0.082235515,-0.021847954,-0.005563468,-0.018335124,0.0126292,0.021942923,-0.031157931,0.09032411,0.051045526,0.060983572,-0.09786149,-0.0031406102,0.017586295,0.10857947,-0.10231069,-0.01788674,-0.07163048,-0.04014908,-0.038520567,0.02409538,0.018282702,-0.045138612,-0.011656213,0.014910622,-0.096789375,-0.012651895,0.008974235,-0.038028672,-0.0728822,-0.031074349,0.010384595,-0.070145115,-0.09101268,-0.0070660985,-0.0036688675,-0.037318908,0.04198629,0.063252896,0.06640602,-0.08869715,-0.067600906,0.09206732,0.025117857,-2.2274804e-33,0.03208191,-0.07352037,-0.04029133,-0.07671384,-0.08807628,0.071514644,-0.003495685,0.013601461,0.0037311588,0.043939553,-0.013560621,0.054171015,0.015719477,0.021502975,-0.018978128,0.034119904,0.10418035,0.13993521,-0.012854344,-0.025526894,0.0039632707,0.062895596,0.05879617,-0.00057711295,0.04321511,0.056045856,0.09074869,0.0438785,6.909515e-05,0.03858459,0.030964216,-0.047984406,-0.04272886,-0.019754605,-0.103801966,0.085397296,-0.09060047,-0.07252287,0.033037383,-0.0009493739,-0.062828995,0.02731279,0.033908803,0.10465014,0.096761666,-0.013733858,-0.107169345,0.041305125,0.0031449075,-0.058183428,-0.010410053,0.0044323406,0.009458757,-0.056364443,0.020136885,-0.0039072405,-0.030774755,0.053122286,-0.020892838,-0.10364955,0.017233543,-0.029524408,0.014027591,-0.07836297,0.050064348,0.12025107,-0.022817759,0.038461592,0.042579133,-0.07576452,0.011719733,0.07695876,-0.028447332,-0.078843355,0.04212436,-0.002381956,-0.035712935,-0.1024913,-0.035708155,0.028688673,-0.05987207,-0.012720353,0.059888937,-0.017731247,-0.066815875,-0.07204712,-0.009404767,0.044775896,0.040380556,0.013252125,-0.039742503,0.0002625238,0.033014018,0.082359955,0.13214839,-2.7317087e-08,0.03904493,-0.05231125,0.04280432,0.04631314,0.0031535202,0.011668749,-0.021312969,-0.0096632745,0.017620604,-0.028857151,-0.1053303,0.07356004,0.027113715,0.022234485,0.10771192,0.0014229866,-0.018738749,-0.07851467,-0.010721274,-0.039032508,-0.064823166,-0.030427773,0.01246918,0.066035256,0.014964545,-0.120203435,0.021248428,-0.042927176,-0.020774547,-0.00070968596,0.038197935,0.0038259272,-0.05780901,-0.040969957,-0.00018700334,0.025914924,-0.055633657,0.06209663,0.052587993,0.008673988,-0.005919454,-0.048939176,-0.09161608,0.050665848,-0.01446864,0.08345644,-0.01443806,0.037455477,-0.040087074,-0.012254858,0.030019248,-0.060733974,0.036860842,0.056983955,-0.018611649,-0.0047033583,0.001700897,-0.028454142,0.037379302,0.046543162,-0.051769268,0.03003899,0.16563953,0.027637092 +4.2.3.134,"A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase).",384,0.99999994,0.0352018,-0.08460566,-0.07795856,-0.07944926,0.04220023,0.05432567,0.028596967,0.008198809,0.035352208,0.05941223,0.05593007,-0.016276307,-0.085602604,0.10062835,0.01705134,0.060107894,-0.039712805,-0.050959837,0.038472895,0.020545587,0.10524346,0.023324875,0.028267896,0.037330862,-0.02205693,0.07543361,0.03419973,0.034368385,-0.0010320478,-0.028533058,-0.04072257,0.008761073,0.026236566,-0.06718292,0.072179265,0.10869746,-0.060487445,-0.043645058,-0.01806118,0.019484853,0.0689421,-0.032457244,-0.023155352,-0.010761567,-0.05231944,0.030354707,0.009555743,0.013028373,0.046537656,-0.06015326,-0.040291432,-0.05566712,-0.00539653,0.0236059,-0.030822402,0.07038129,-0.04787727,0.078654744,-0.029752245,0.008660221,-0.054955374,0.06626652,0.08226472,0.04554013,0.075801365,0.029857395,0.009816926,-0.07946827,-0.029911922,-0.02130104,-0.032875005,-0.05649885,0.12714899,0.013101473,-0.021861082,0.07036359,0.013360078,0.007109097,-0.039657135,-0.017537184,-0.04244285,-0.057634056,0.01526143,0.07878241,0.017509451,0.03661295,-0.044405915,-0.036940087,0.00062943995,-0.025010886,-0.029733164,0.013285913,0.030551022,-0.036849685,0.029002134,0.0058072596,0.009671187,-0.01948094,-0.072244,-0.0048455996,-0.019157015,0.06914626,-0.06425365,-0.06484532,-0.030142123,0.02324947,-0.025189506,-0.046650663,-0.025364242,0.007923415,-0.028402489,0.013763944,0.05580218,-0.0070894263,-0.00731942,0.013547852,0.012776915,-0.047849737,-0.063613184,0.028951906,-0.0069332104,-0.07458824,0.032152627,0.10832542,-0.07500624,-0.00950492,-0.046750277,8.883127e-34,0.039148275,0.045255434,0.081592634,-0.03805494,0.010510954,0.01948176,-0.03173839,-0.02177169,0.0033349146,-0.09450795,-0.03181622,0.033599824,0.07911466,0.046606947,0.004213331,-0.012991649,-0.028492084,0.045760322,0.12563945,-0.036685925,0.056953344,0.023033971,-0.020163277,0.077517755,-0.021487605,0.109037705,-0.03945186,-0.031073071,-0.029910304,0.007951668,-0.017946005,-0.053913042,-0.08126912,-0.02193514,-0.03494929,-0.05767279,-0.09180644,-0.085138276,-0.0587363,-0.005887523,-0.055861242,-0.03172281,-0.008279832,0.020063356,-0.0037418616,-0.12274212,-0.06295411,-0.0016531935,0.008942366,0.0497466,-0.015235097,-0.053390387,0.060369678,-0.049769565,-0.10561207,-0.07308371,-0.043004308,-0.021219669,0.0024761858,0.018762052,0.049086515,0.04045991,-0.06404081,-0.079344645,-0.013734684,0.009426301,-0.013610135,-0.10564827,0.014179496,-0.0059110047,0.028870098,-0.0031468344,0.07140147,0.024068033,0.021148816,-0.069736056,-0.020163158,0.021212686,-0.056441847,0.075358585,0.08005666,-0.106215514,0.016907545,-0.015318914,0.006534035,-0.026572509,0.06314461,-0.016352193,-0.027475458,0.017688658,0.034202054,-0.12328182,-0.02917279,0.05492601,0.004589405,-1.718858e-33,0.07904427,-0.046554476,0.06275829,-0.043847024,-0.0064043603,0.020163272,0.07378542,0.016293723,0.07237633,-0.056789383,0.089388564,-0.019844722,-0.016202167,-0.058427796,0.007144896,0.10338237,-0.023986451,0.033482857,0.0541814,0.0330561,-0.01346891,0.04778284,-0.017918374,0.11177469,0.09331369,0.027262708,0.005837088,0.02174376,-0.079789035,0.0018757429,0.00984419,0.061540656,-0.043919347,-0.06272673,-0.06309276,-0.021405725,-0.10209003,-0.046668686,-0.031629223,-0.012068045,0.058112234,0.08781887,0.047669787,-0.021708999,-0.017888688,0.07242075,-0.042141624,-0.0021372996,0.013141462,0.021786263,0.032315053,0.06862537,-0.02664871,-0.0027359868,0.08406731,0.05336866,-0.05012347,0.0716929,-0.057569325,-0.02248819,0.008483867,-0.04696977,-0.015858024,0.10707222,0.062187117,0.07069295,-0.015867013,0.05923374,0.03490705,0.03856579,0.08366907,0.045860227,0.06801929,0.056058966,-0.037815087,0.011584025,-0.04582993,0.010021959,0.01944642,-0.06170224,0.028626135,0.0038267972,0.019541526,-0.071847975,0.06688383,0.008822292,0.009513154,0.03716448,-0.025400488,0.021086453,0.037091896,-0.023033913,-0.01695143,0.02749061,0.11116834,-3.6538314e-08,0.10836277,-0.03257816,0.012452234,-0.07254277,1.8343679e-05,-0.035339624,0.101634145,-0.028989166,0.011602287,-0.018084254,0.018270157,-0.0027643475,0.014040267,-0.018920386,0.09795897,0.034611993,-0.029514004,0.052262865,-0.008325214,-0.03519212,-0.04498163,-0.007936324,-0.12027421,0.022617212,0.04510765,0.021023115,0.026970245,-0.027068121,-0.027162865,-0.0062673986,0.056605842,-0.02034646,-0.024846727,-0.03569559,-0.031026503,0.055391755,-0.03243736,-0.014779508,-0.13031372,0.011370708,-0.06956699,-0.019590328,0.0051334123,-0.025531806,0.049329218,0.06267464,0.0017390337,-0.007145439,-0.015802333,-0.06891598,0.05971865,-0.004397434,-0.06141933,-0.10540615,-0.13954282,-0.043806497,0.017958714,-0.04165411,-0.03870142,-0.11076736,0.0697103,-0.04584981,0.13167523,-0.026884705 +4.2.3.135,Isolated from the fungus Armillaria gallica. Delta6-Protoilludene is the first step in the biosynthesis of the melleolides.,384,0.99999994,0.013905594,-0.02916856,-0.07338882,-0.016186455,0.01074809,0.037028577,-0.042345177,-0.016676148,0.054724567,-0.025440069,0.07779988,-0.07667367,-0.08174642,-0.06656726,-0.04623476,-0.007994325,-0.03966976,0.03518436,-0.029954337,0.020728441,0.018825907,-0.00045530353,0.015614724,0.008881209,0.038426977,-0.01196908,0.03081383,-0.025463274,-0.0020424295,-0.10343941,0.013073047,0.0156198805,-0.004415165,-0.046515763,0.045523286,0.02926495,-0.026344128,0.057971075,0.07357652,0.0027068546,0.017741377,-0.066486925,0.056803893,-0.072399475,-0.075269416,0.020002784,-0.036556985,0.034804296,0.07004487,-0.0019166265,-0.015180731,-0.06474939,-0.026360534,0.0030947842,0.017295763,0.009578483,-0.004841682,-0.074879356,0.022017654,0.032547295,0.049927395,0.029062826,-0.022381004,-0.036918547,-0.09265486,-0.008493589,0.0040105116,-0.0404306,0.05037148,-0.022326075,-0.060272947,-0.027512053,-0.014366415,0.025616093,0.041935153,0.11426943,0.010375761,-0.019537237,0.07406122,-0.033879407,-0.012071052,0.011048771,-0.002561167,0.026613306,-0.023275413,-0.013502776,0.08104237,0.10664272,0.06753082,-0.0099768955,0.04837808,0.09882792,-0.007340892,-0.068402,-0.065500624,0.07938378,0.0016002313,0.0300434,0.042024374,-0.024803856,0.07960354,-0.02391206,0.026600312,-0.0041441666,-0.07019944,-0.04927241,-0.06349733,0.022225155,0.013642458,-0.04995348,0.056431364,-0.06851411,0.021342862,-0.0027094053,-0.042919412,0.035114776,-0.00971582,-0.03969287,0.012172343,-0.031998996,-0.013723401,0.057335153,0.04097424,-0.0038236117,-0.03781065,0.038119525,-0.040082764,-4.8477883e-34,0.073063664,0.05626888,0.016002947,0.040531088,0.0345165,-0.041504614,-0.04362388,-0.06614457,-0.03332582,-0.10669543,-0.07276363,-0.032800976,-0.046674468,0.010147682,0.048319787,0.0521171,0.0478612,-0.04915502,0.0490089,0.011080858,0.01898866,0.072571,-0.04262321,-0.02656424,0.0045123845,0.073948294,-0.02179252,-0.010907481,0.02588119,0.010268437,-0.041965626,-0.0685327,-0.030142542,0.062082786,0.060845967,0.022343934,0.0046557803,-0.05077943,-0.08406842,-0.0033488767,0.042604208,0.05080437,0.03222518,0.0017266513,0.022838466,-0.03272963,-0.06460513,0.03297894,0.08991287,0.0075719617,0.017613756,0.04000848,0.14350808,0.018592317,0.010078314,0.00010582287,-0.07866206,0.065931804,0.019699374,0.037948996,-0.0028722682,0.10040929,0.027224835,0.090596795,0.0799937,0.06458021,-0.08289097,0.043835383,-0.08010457,-0.0035806105,-0.010454211,-0.07362063,0.04410778,-0.013102399,0.007170846,0.0668413,0.01975738,-0.024301007,-0.053202182,-0.044375848,-0.058585137,0.044466022,0.0074758166,0.028202847,-0.06989597,-0.021247119,-0.03443114,0.038410705,0.008055707,0.017264942,-0.04339809,-0.016970798,-0.0878932,0.09919982,-0.08921981,-8.828564e-34,0.11813747,-0.05667455,0.05294443,-0.06469144,-0.0390457,0.08184741,0.0022121377,0.00567807,-0.04084361,-0.01881204,-0.035595633,-0.023798935,0.08117388,-0.04567078,-0.024827229,-0.037242882,0.12174847,0.11667837,0.0063325814,0.04868288,-0.062465765,0.109551236,-0.017896885,0.0153254615,0.014537486,-0.017153693,0.07154249,0.012477271,-0.1105142,-0.02998316,0.051753502,0.024120498,0.020240722,-0.097275205,-0.059496216,0.049315754,0.026175503,-0.0703114,0.098711394,0.09464374,-0.04126999,0.010592916,-0.048150945,-0.011551469,0.08765649,-0.008204376,-0.046589345,0.0063466015,-0.051639374,-0.031092836,-0.018847598,-0.052915543,0.026933791,-0.041500013,0.0055669835,-0.054366723,0.09870465,0.042206444,0.07530173,-0.028942838,-0.06370723,-0.017493064,0.0068239393,-0.019898273,0.061371773,0.11131485,-0.03940094,0.02658011,0.0021304283,-0.060360838,0.087395936,0.060997367,-0.0507541,0.12018028,0.052707944,0.029411424,0.034678552,-0.07499978,0.041656867,-0.013529037,-0.0072842883,-0.017061133,0.08161587,-0.028818708,-0.043108273,-0.051277112,0.042668656,-0.030446397,-0.024416639,0.021725504,-0.0077916156,-0.041699223,-0.076141775,0.14727977,0.06329969,-2.3925466e-08,0.10623559,-0.0062925224,0.010758016,-0.07970651,-0.064986676,-0.00015075672,0.01988368,0.0020959848,0.0537529,-0.03671139,-0.06610696,-0.018631648,0.08254879,0.043102346,0.010201932,0.017321302,0.049820714,-0.038866,-0.07492596,-0.06733863,-0.033719,-0.012709769,0.041107696,-0.017234234,-0.0038001833,-0.12849295,0.03859625,-0.045199722,-0.022525636,-0.032519292,-0.06396709,0.031074192,-0.033542816,-0.05283821,0.01164865,0.048911497,-0.02962255,-0.053430375,0.024230326,0.05261166,0.014231714,-0.0476541,-0.09025442,-0.041845515,-0.04067171,-0.027587147,-0.043727905,0.03348948,-0.031809997,0.0020132363,-0.0012291416,0.03822151,0.016075416,-0.047255855,-0.10226351,-0.082933046,0.024289424,-0.000613257,-0.0012409698,-0.05154811,0.011611468,0.03587104,0.15896992,-0.023544263 +4.2.3.136,Isolated from the roots of the plant Matricaria chamomilla var. recutita (chamomile). The enzyme also produced traces of five other sesquiterpenoids.,384,1.0,-0.02529393,-0.0417945,-0.1576002,0.020737391,0.015725756,0.020710798,-0.03964393,0.03772552,0.056330007,-0.020019626,0.11794124,-0.06465362,0.04837394,-0.09012161,-0.08813236,0.0068608285,-0.0010014032,0.05015781,-0.0077033453,-0.013936229,0.027906166,0.008302076,-0.019874373,0.031691663,0.068767846,0.022201696,-0.00026889204,0.020934861,0.011859258,-0.093689464,-0.020793783,0.02006423,0.055982407,-0.035087552,0.033276748,0.08739311,-0.037348013,-0.031046359,0.11716721,0.01939639,0.0062080794,0.019035542,0.07281145,-0.07724011,0.001229312,-0.054608483,-0.00909105,0.031153793,0.0581125,0.01612786,0.012694238,0.009078263,-0.081235744,0.08554442,-0.04330239,-0.077838525,0.04782756,-0.035879783,-0.037826687,0.08917987,0.03940549,0.01377824,-0.005804633,-0.039258637,-0.056368098,-0.051141094,-0.06443621,-0.0025527016,0.062174946,-0.052686036,-0.05250377,-0.05133807,0.023057304,0.030484846,-0.090867594,0.052442614,0.007405164,0.007890929,-0.0038193227,-0.015324746,0.060029138,0.034641195,0.10633948,0.05286812,0.033770416,0.03525428,0.033938665,0.07359018,0.07617535,0.004138098,0.056302514,0.10283416,-0.0009956576,-0.017809922,-0.078420244,0.044013035,0.025250208,0.022898264,-0.022687826,0.010007414,0.06562269,-0.025558969,-0.0053374297,-0.08893011,-0.06130309,0.07062642,-0.05415175,-0.07723539,0.034796398,-0.044307172,-0.051543158,0.007668426,-0.06518985,0.014220357,-0.024223171,0.07645748,0.06380413,-0.06043962,-0.031302623,-0.0148783,0.027586248,0.001558247,0.06380366,-0.0465289,0.028176611,-0.012423907,-0.039842173,2.4834412e-33,0.0076826676,0.047226023,0.012544084,0.040395096,0.0112904,-0.005246084,-0.022813518,0.084393024,-0.068860576,-0.06295363,-0.056280475,0.01232968,0.0038086441,-0.03295955,-0.016344935,0.02910359,0.0556099,-0.09797927,0.05744619,-0.08852544,0.010365776,0.02084253,-0.038866833,-0.06545913,0.0329067,-0.01334245,0.01741527,-0.0042714756,0.039132398,-0.01800631,0.036364272,-0.06559203,-0.05708157,-0.0070609967,0.06735328,0.05406118,0.022431618,-0.031726956,-0.12719345,0.052525066,0.03246972,0.059202164,0.04326076,-0.012575996,0.053396977,-0.04351655,-0.066614814,0.035074905,0.113982484,0.017486813,-0.0434648,0.030432742,0.076855816,-0.03764995,-0.09453539,-0.04950341,-0.039333005,0.03107806,0.050128147,0.06509206,0.030168755,-0.010959044,-0.08917853,-0.03520957,0.020778703,0.12099676,-0.15357907,-0.0155578125,0.016897455,0.0452553,-0.07484349,-0.032178726,-0.01669821,-0.038488615,0.05491772,-0.005141793,-0.053418417,0.041987434,-0.04462757,-0.010503446,-0.03512875,0.0058675925,0.026042217,0.020691771,-0.06996837,0.0050666574,-0.022693293,0.083494924,0.0037216165,-0.03840056,0.04792169,0.013933347,-0.049897667,-0.00484435,0.032998055,-2.0890678e-33,0.030306755,-0.05573191,0.015800029,-0.015451774,-0.015867718,0.049743477,-0.013814665,0.027894627,0.025519816,0.019737344,-0.0023087726,-0.024278706,0.122239165,-0.05092316,0.027315544,0.06575762,0.03415601,0.109504305,-0.012883339,-0.03269524,-0.027858227,0.119009025,0.062065482,-0.0375716,-0.0685289,-0.0009487591,0.048939206,-0.019554397,-0.021971688,0.061762493,0.0042593554,-0.029904084,-0.04777898,0.024512628,-0.09255505,-0.015908457,-0.10105925,-0.041270263,-0.008065273,0.096980095,-0.04232853,0.016108863,0.0248775,0.08035405,0.061647106,-0.041287772,-0.11647313,0.050905935,-0.023978222,0.0052887863,0.06740974,-0.046581727,-0.029771743,-0.041202176,0.042573202,0.0031151278,-0.01119583,0.03775261,0.012562565,0.0114374915,0.013406565,0.040190797,-0.1107045,-0.06363203,0.117896706,0.09400655,-0.037370242,0.018719412,0.024009503,0.0346585,0.080295175,0.053285018,-0.046935756,0.0034227716,0.009148256,0.0699923,-0.059245877,-0.09233527,-0.056306057,0.035328563,0.019161923,-0.033373006,0.057701986,-0.045136515,-0.050448883,-0.064740375,-0.0085935015,0.02576251,0.03809081,-0.0070834947,0.02251191,-0.069025524,-0.038725264,0.096329056,0.11027464,-2.6838e-08,-0.031941984,-0.026643865,-0.03424509,0.032730326,0.014828762,0.04150558,0.029785244,-0.01524418,0.053270385,0.013334685,-0.02767291,0.00015961443,0.028004188,0.06445217,0.040618047,0.019129073,0.049973052,0.07820656,-0.006279577,0.034590043,0.025067473,-0.02611153,-0.024222579,0.050376847,0.031768978,-0.07431945,-0.03916921,-0.027072404,-0.026801456,0.0057994314,0.026021218,-0.034698963,0.023895055,-0.052729778,-0.07412579,0.054090228,-0.029083222,-0.011357011,-0.03079103,0.0057721804,0.05608748,-0.0935577,-0.019402599,-0.015486888,-0.08937514,-0.011474104,-0.0057850247,-0.018022483,0.018326344,-0.0031518922,0.03333611,-0.060535964,0.038979787,-0.061912842,-0.04415289,-0.092071295,0.018708637,-0.035818055,-0.0076345527,-0.08470761,-0.041398924,-0.0007256871,0.15286124,0.04037347 +4.2.3.137,Isolated from the plant Selaginella moellendorfii. The enzyme also gives two other sesquiterpenoids.,384,0.99999994,-0.033358395,-0.015882904,-0.11627735,0.0015360718,0.005543322,0.038637307,-0.03402595,0.047559433,0.049279746,-0.09236041,0.062424414,-0.06577054,-0.027918952,-0.09502772,-0.065215066,0.033247903,0.04488276,0.019897932,0.03238684,-0.047370773,0.01905586,0.056859605,0.040055793,0.023122704,0.04147748,0.029844578,-0.04928232,0.0135379825,0.06036165,-0.0850355,-0.01865364,-0.00368334,0.057542358,-0.04262814,0.069674134,-0.02498689,-0.048008844,0.014298994,0.06711614,0.07966154,0.04285581,0.0011534906,0.0061342493,-0.055433854,-0.11088791,-0.027947927,-0.03347327,0.014260859,0.05255267,0.01870432,-0.019884476,-0.090406924,-0.08036307,0.047356725,0.031142943,-0.017344996,0.022107223,-0.027299663,-0.05456642,0.08153617,0.06771232,0.04249788,-0.008004489,-0.008415703,-0.04912401,0.0050902776,-0.053709455,-0.0007954783,0.064863145,-0.055955112,-0.018897234,-0.076947115,-0.008765517,0.012133595,-0.115107924,0.03639824,0.017099092,-0.034038235,0.018773552,0.012365493,-0.008555995,-0.02313755,0.068740144,0.05161503,0.01309763,0.022440579,0.013852155,0.038121257,0.02183142,0.024677353,0.035413224,0.033207215,0.0029501584,-0.07384582,-0.033380084,0.04221533,0.009029948,0.02981963,-0.016151348,-0.0018948913,0.011544432,0.009659492,0.0065250155,-0.113669656,-0.08342133,0.08129248,-0.05493255,-0.10454962,0.05365689,-0.06971024,-0.0073106266,0.001716478,-0.014982341,-0.023954025,-0.0083883805,0.020273836,0.056343988,-0.0413249,0.04016769,0.02489783,0.003980864,-0.009505404,0.06727265,-0.021199208,0.026251785,0.049122658,-0.07418382,1.9398673e-33,0.03456256,0.03687213,0.018972691,-0.0005264163,-0.026218068,-0.022921603,-0.009151659,0.06773601,-0.14152983,-0.05055595,-0.09961904,-0.0789191,0.0032690149,0.010270365,0.042955738,-0.0052398127,0.039600138,-0.033703648,0.099934354,-0.07215366,0.07123567,0.04533762,-0.045111038,-0.04896589,0.013176499,-0.036131013,0.00446315,-0.016340619,0.053860135,-0.0034226493,0.066559896,-0.07084396,-0.068656705,-0.0141905425,0.07847064,-0.004192675,0.019733733,-0.004349579,-0.11862747,0.040433664,-0.019492203,0.036962327,0.011461893,-0.027760545,0.07086309,-0.04501086,-0.029940069,-0.0017883626,0.19062415,-0.0008817358,-0.039733358,-0.030072771,0.1024102,0.0064516673,-0.04396145,0.018580759,-0.01191302,0.0348616,0.038489357,0.08382821,-0.01367726,0.033308312,-0.048959285,-0.06737136,0.13771878,0.11474101,-0.11015889,-0.054500468,-0.07981634,0.0043092454,-0.032811277,-0.046978243,0.03674568,-0.085708246,0.061949775,0.0045292242,-0.040373135,0.008990872,-0.01474512,-0.011411158,-0.032256562,-0.029416818,0.059195362,0.0020365738,-0.07125012,-0.051680233,0.012682142,0.07693985,0.0029290842,0.05349681,0.045098085,-0.042588267,-0.05174202,0.0007291661,-0.0098989755,-1.7773836e-33,0.015172174,-0.06044177,0.009188328,-0.06779847,-0.05149971,0.13680299,0.0024816918,0.04547768,-0.00868115,0.053622436,-0.0012793273,0.03682557,0.07249108,-0.06580365,-0.0380176,-0.008139193,-0.0019337633,0.12965365,-0.0016569091,-0.008565496,-0.008467112,0.07523119,0.044726983,0.041486833,0.0045360997,0.0181925,0.086422876,-0.028992409,-0.051802676,0.03069156,-0.0025199691,-0.016268047,-0.040640146,-0.0051637436,-0.11117591,0.08720049,-0.0812682,-0.035247944,-0.027903112,0.049723312,-0.07994856,0.014073782,0.023064865,0.08253835,0.10503014,-0.02842961,-0.12949729,0.057840005,-0.033882752,-0.004573807,0.020723324,-0.008091124,-0.006579314,-0.014743461,0.045000646,-0.06884034,-0.009906278,0.0012522872,0.034469385,-0.033158213,0.055305097,0.006225197,-0.071918465,0.038688418,0.119345084,0.055582136,-0.043958936,0.02294609,-0.004514689,0.0077395895,0.0020782165,0.055751204,0.0006201804,0.034579113,0.055804394,0.025637904,0.0127563765,-0.075824335,-0.024784924,0.009094249,0.009088737,-0.030387903,0.034727108,-0.048674442,-0.052191954,-0.06444077,0.053909868,0.035609186,0.07342393,0.0017332247,-0.016266344,0.039082605,-0.07950192,0.08016645,0.11041079,-2.0986203e-08,0.08548236,-0.03159581,0.014094782,0.0129110245,-0.012753058,-0.059332885,0.019436195,-0.015447443,0.05415652,0.034123402,-0.04008599,0.01462277,0.06445195,0.024525704,0.095957875,-0.04334168,0.049862914,0.0019613141,-0.0018585697,0.03879268,-0.02105861,0.021498747,-0.025826095,0.0025655807,0.024413168,-0.11155249,0.032011833,0.0035121683,0.03960153,0.040614564,0.045053557,-0.003951699,-0.017513324,-0.03161739,-0.044936493,0.0384745,-0.043554917,0.0047124648,-0.0095129805,0.0104124835,-0.03200642,-0.10003216,-0.010057921,0.002667565,-0.038333613,0.041411784,0.016172975,-0.015399656,0.018739043,-0.02516358,0.017561052,-0.042617038,0.010527568,-0.03588215,-0.07957079,-0.06303002,-1.3065814e-05,-0.04819201,0.009273857,-0.08110227,-0.06651265,-0.030678976,0.14646134,0.07017714 +4.2.3.138,Isolated from the plant Phyla dulcis (Aztec sweet herb). (+)-epi-alpha-Bisabolol is the precursor of the sweetener hernandulcin.,384,1.0,-0.09305207,-0.00973166,-0.13442554,0.035923023,0.015910728,0.051862884,0.03185672,0.023435932,0.033010837,0.035163008,0.10371145,-0.044907976,0.021032352,-0.037610438,-0.0098150475,0.028707542,-0.0628099,-0.031280432,-0.03827592,-0.07520183,0.02559274,-0.0017816959,0.053098857,0.08635102,-0.047148902,0.016034927,0.00459223,0.056742836,0.028731475,-0.013902926,-0.018702984,-0.021324165,0.11790114,-0.03412451,-0.042420257,0.104058065,-0.0831788,-0.04899744,0.07672273,0.0066315015,-0.035500105,0.034170516,0.03508967,0.004386981,-0.022055713,-0.07518831,-0.05229176,0.05564556,0.007617695,-0.022206536,0.053736046,0.0074141277,0.0030180798,0.010178125,0.061954547,0.0027466265,-0.054522846,0.0124713555,0.028153954,0.09475724,0.08520957,0.05945618,0.020138375,-0.00892704,-0.07442883,0.07386124,-0.015780441,-0.021311449,0.12930554,-0.082318775,-0.02524036,-0.028226223,0.057360526,0.097162776,0.03220877,-0.03912578,0.03610794,0.020615429,-0.055318587,-0.035545066,-0.02955879,-0.03170743,0.020305652,0.06595659,-0.03033158,0.028114695,-0.018974151,0.02264765,0.06175006,-0.025072852,0.076738656,0.022250986,-0.05730382,0.014117608,-0.021654608,0.02110729,0.045264583,-0.0729055,0.046459008,0.021224637,0.08738006,-0.003962325,-0.022525337,-0.09137344,-0.011489031,0.034152146,0.040963013,-0.027993474,-0.014050831,0.016228633,-0.0037389896,-0.030706212,0.003480696,-0.0556857,-0.095763475,0.04236311,-0.020290311,-0.013262952,0.00969667,-0.034184538,-0.04003266,0.024763567,0.06716337,0.04992666,-0.0090714,-0.03614682,-0.06434916,6.3931223e-35,-0.008681044,0.040013928,0.0063097365,0.024541186,0.01111778,-0.015127717,0.018416664,-0.00669738,-0.03453758,-0.11509131,-0.059460007,-0.05686243,-0.03253255,-0.0043865787,-0.018198315,-0.062393054,-0.041581646,-0.063832596,0.10635017,-0.038142957,-0.047689434,0.111537226,-0.02923112,-0.037972525,0.024821807,0.03571843,0.008661451,0.04480965,0.046869084,-0.0006100666,0.06497716,-0.052239466,-0.041009754,-0.048643477,0.06441196,0.026567262,-0.041228574,0.0022796493,-0.02602862,0.06947227,0.08431836,0.03201305,0.065373145,0.05220063,0.015786227,-0.0121136,-0.080757946,0.066209994,0.08517247,-0.041437253,-0.03180199,0.056326505,0.05878328,0.020339089,-0.13546553,0.014673495,0.015180643,-0.021710848,0.08643416,0.0895472,0.00064674416,0.08311695,-0.048831932,0.011656836,0.010538696,0.017240873,-0.06751081,-0.020154633,0.003058943,-0.060087126,-0.0010317278,-0.010848941,0.017518997,-0.028452871,0.044895913,0.036090627,0.008435396,0.068450086,0.008360267,-0.00998342,-0.050224103,-0.026898505,0.023786452,0.08251748,-0.08843511,0.052054517,-0.055166114,-0.02428078,-0.026975885,0.072414145,-0.04084817,0.02787315,0.015499473,-0.02597673,0.01721402,-8.192314e-34,0.04155183,-0.029254481,0.07395923,-0.022817452,0.028291233,-0.004098292,-0.043026574,-0.0019332953,-0.013087747,-0.010211101,0.08955626,-0.0059599034,0.06104034,-0.023564521,-0.029576117,0.167742,0.032719385,0.15587595,-0.06574519,0.02393578,-0.09134475,0.02793319,0.006793532,-0.027758988,0.0055682585,0.055483375,0.110794894,-0.0116544,0.014097652,0.0022821568,0.016857773,-0.06449038,-0.13506933,-0.10043199,-0.1096854,-0.02872618,-0.10209754,-0.09656667,-0.05355896,-0.0026109335,-0.007018678,0.012160805,-0.041038997,0.0134662,0.04821231,0.0722655,-0.0073583624,0.06312473,-0.080894694,0.04579817,0.03199823,-0.001488917,0.0087458175,-0.029047081,0.055922814,-0.039794125,0.0818717,0.053424202,0.0048390585,-0.06112851,0.0149808,-0.009209735,0.024014046,-0.032089792,0.05087089,0.040807668,-0.016354114,0.04557761,0.019367741,-0.07491279,0.078105904,-0.02179614,-0.03268661,0.00444175,-0.032922797,0.09252892,-0.03482197,-0.047988094,-0.0022043178,0.013853013,0.021706564,-0.048863884,0.04075227,-0.037578724,-0.049728278,-0.02906649,0.03667746,0.0037618133,0.037604917,0.041796528,-0.077336244,-0.002789793,-0.08032402,0.008923451,0.08917182,-2.3642041e-08,-0.016489718,-0.067210585,-0.06583295,-0.024072094,-0.051146135,-0.008589039,-0.015584181,-0.030270232,-0.012310725,-0.028320346,-0.00892209,0.049658623,-0.0101564,0.056724872,-0.07056956,-0.021993922,0.044740777,0.08052532,0.015589146,-0.039239574,-0.10729773,0.021071676,-0.002423053,-0.059748493,-0.017351331,-0.088451214,-0.022621445,0.007015893,-0.027716655,-0.09577399,0.038693096,0.028880617,-0.030612575,-0.081359155,0.047340512,0.09534013,-0.01139462,-0.03398769,-0.07522844,0.027364923,-0.046653196,-0.018095871,0.010103732,0.012035595,-0.02043035,-0.020972116,0.026403893,0.13699143,0.02844188,-0.049846817,0.0063920626,-0.021930497,0.021910604,-0.105225235,-0.030126639,-0.04908244,0.0045548426,-0.028539555,0.02732508,-0.0043324833,-0.020223625,-0.06012985,0.11287509,0.026539775 +4.2.3.139,"Isolated from the plant Valeriana officinalis (valerian). Note that due to a different numbering system the product is also known as valerena-1,10-diene.",384,1.0,-0.05341365,0.044231962,-0.12923475,0.014682025,0.06262669,0.053548988,0.015101799,0.022438694,0.06049304,-0.064790286,0.07652372,-0.061340455,-0.037311338,-0.04064417,-0.055456895,0.0468353,-0.037296534,0.008928679,-0.0070347073,0.06589294,-0.029119935,0.13604797,0.00014835683,0.01857639,0.04164951,0.03217369,-0.020484686,0.044204373,0.0691242,-0.06879556,0.011537126,0.0762613,0.041346963,-0.017034968,0.0078104716,0.03237854,-0.05947857,0.01768947,0.07616419,0.11023881,0.004616733,-0.009667846,0.013851324,-0.13274704,-0.02559286,-0.028960655,-0.08017365,0.03670255,0.054589167,0.004118627,0.06762861,0.028393941,-0.07963525,0.091941185,0.015112735,-0.0891804,0.053123306,0.03119169,-0.008956159,0.023584343,0.08280662,0.057321362,-0.0073257606,-0.020888789,-0.12598552,-0.004250996,-0.060300812,0.0065722717,0.072768,-0.08681024,0.06158154,-0.020947225,0.03994091,-0.004228955,-0.07954217,0.07905324,0.028946852,0.007683327,0.044086214,-0.008625917,-0.0281758,0.047159415,-0.008881604,-0.006952142,-0.033644404,0.020670945,-0.027166039,0.10867506,0.02149707,-0.004465847,-0.053059254,0.09505041,0.03684497,-0.038031973,-0.014981268,0.011999546,0.1031465,0.025722597,0.000419895,0.024746587,0.03567984,0.0119173275,-0.07038232,-0.08075836,-0.0981895,0.015799094,-0.021869844,-0.062290058,0.08884716,-0.07779811,-0.033192825,-0.0438963,-0.01559694,-0.05236894,-0.0439047,0.024295451,0.043644316,-0.044125214,0.030114165,-0.025873173,-0.050252356,-0.024823312,0.06550092,0.0034672306,0.029561577,0.032068767,-0.05879619,-7.3510026e-34,0.060885157,-0.008058546,0.030062295,0.037526004,0.011927692,-0.06137863,-0.01819152,0.0395189,-0.06106959,-0.06721904,-0.09001234,-0.015496657,-0.03649365,-0.027003,-0.012075857,-0.0057039508,0.04836157,-0.07759621,0.07429274,-0.084627815,-0.024906477,0.068009734,-0.025029358,0.0032903387,-0.0010449432,-0.024270419,0.03299913,-0.050954178,0.04093848,-0.01713079,0.017966624,-0.05545321,0.0053189085,-0.011401578,0.042591847,0.06795205,-0.08572561,0.0039525093,-0.041906547,0.049003147,0.042679626,0.017097611,0.07367172,-0.017581824,0.048414595,0.0115194945,-0.049890928,-0.023016732,0.10639727,-0.043664124,-0.027691213,0.056684986,0.048881423,0.03261929,-0.116717495,-0.06683212,-0.005052325,0.04105738,0.01677017,0.07786692,0.0029404084,0.07066344,0.0010575869,0.030624624,0.024587084,0.034650434,-0.18432961,-0.04904517,-0.04245102,-0.0048996164,-0.03648172,-0.020662397,0.04015988,-0.12664482,0.04733067,0.04692301,-0.005132408,-0.024585066,-0.005871598,-0.0013562682,-0.04550996,0.0053658197,0.0021290635,-0.0015927629,-0.065681845,-0.01603731,-0.048943583,0.021082127,-0.039287828,0.06723819,-0.0026064762,-0.010311495,-0.06269315,-0.06568917,0.044164546,-1.2458709e-33,-0.004034698,-0.05556905,-0.0036453973,-0.08909685,-0.010349834,0.09482702,-0.05246359,0.0014653227,-0.036666796,0.023048948,0.04722922,0.034520946,0.113526054,0.0013240068,-0.025043972,0.028324071,0.051341806,0.1166507,-0.021488462,0.021113621,-0.065742105,0.04065841,-0.097135745,-0.05983876,-0.048490155,0.010399396,0.03353651,-0.05254521,0.019462772,-0.021657238,0.052490767,-0.01981516,-0.025356796,-0.015012476,-0.017990831,-0.019037692,-0.04014574,-0.13797143,-0.043388527,0.03617298,-0.046961896,0.006903156,0.006850703,0.084155664,0.08645019,-0.024432274,-0.010571209,0.013871398,-0.037897866,0.10532317,0.051786922,0.022712292,-0.03015033,0.014435147,0.04267369,-0.05357718,-0.020427603,0.0947578,-0.0073206383,-0.044089682,0.041037984,-0.0026996036,-0.05293159,-0.0133013055,0.0628451,0.06949103,-0.069035254,0.06623458,-0.028738825,-0.044080704,0.078443,0.020267844,-0.004216022,0.038496446,0.0042463574,-0.0023972583,0.017194174,-0.085724585,0.010226787,-0.037110586,-0.029185154,-0.092768796,0.032526795,-0.035505425,-0.0060197897,-0.034288947,0.046716027,-0.040017735,0.020251418,-0.0062572286,-0.006953359,0.021574276,-0.09030527,0.012443077,0.047057424,-2.8135915e-08,0.0058983993,-0.072082944,-0.03389878,-0.011145695,-0.053671308,-0.0746573,0.06949812,-0.007878011,0.026073597,0.010104533,0.011716402,-0.037005078,0.00021539343,-0.074764125,0.10981422,-0.031877503,0.016816527,0.08461498,0.00552558,-0.0033448061,-0.067975804,0.0032867882,0.003180772,-0.047228567,-0.061623134,-0.09509905,0.021176115,-0.060135808,0.05078813,-0.073792785,0.09523234,0.035263065,-0.067489795,-0.016497934,0.032632086,0.07889612,0.0024684018,0.025359161,0.017905857,0.018967506,-0.013472107,-0.033076864,-0.08697953,0.017886989,-0.012046857,-0.023175463,0.0268615,0.038852308,-0.009954219,-0.03633288,0.0022934382,0.032771774,0.0672027,-0.055729568,-0.0044327476,-0.05319506,0.0043339375,-0.020755088,0.0058573117,0.0039211255,-0.052232236,0.017531125,0.109775,0.10810396 +4.2.3.140,Isolated from the plants Abies balsamea (balsam fir) [1] and Nicotiana tabacum (tobacco) [2].,384,1.0,-0.026247293,0.0023454065,-0.13960221,-0.02231459,0.0518127,0.090677835,0.012268565,-0.030948967,0.00786138,0.054286562,0.09693686,-0.06386933,-0.06262358,-0.045224268,-0.009755008,0.06086816,-0.021049554,-0.009242289,-0.044296402,0.020618498,0.04859434,0.096113846,-0.011958056,-0.005209392,-0.007842021,-0.009446943,-0.06867378,0.0442174,0.06196356,-0.050037943,-0.080474086,0.013792669,0.019418795,0.013762584,0.035250664,-0.06082185,0.017727157,-0.0051116557,0.11548443,0.057265867,0.004476649,0.09551615,-0.011678801,-0.07703295,-0.09324307,-0.018039798,-0.065377414,-0.009713629,0.044919364,-0.05853345,0.017135877,0.034359742,-0.06770638,0.0565113,-0.03175254,-0.091248214,0.014679607,0.01051917,0.011846809,0.0959189,0.041703414,0.019668164,-0.030439617,-0.029413702,-0.024244796,0.012924069,-0.0796138,0.05633861,0.13452451,-0.04856233,0.0041772327,-0.08141067,-0.03169674,0.010266093,-0.018055227,0.019788796,-0.018426126,-0.0021888884,-0.015525004,0.0098380875,-0.06393157,-0.06127068,-0.0063553145,0.06947681,-0.08837588,0.011115558,0.034006335,0.13573107,0.017573068,-0.09866036,-0.014716722,0.028809452,0.041014187,-0.03426398,-0.11951393,0.025416592,0.124565415,-0.03299285,-0.037226744,0.006482354,0.042318076,-0.015420201,0.07881202,-0.09710261,-0.11790948,0.014413189,-0.045124117,-0.04878542,0.114866674,-0.053957604,-0.043569956,0.022443252,-0.077916175,0.01706783,-0.02422863,0.014902074,0.08325366,-0.051579546,-0.019751396,-0.028051969,-0.021509465,0.007293058,0.11595885,0.001157985,0.02260341,0.045575004,-0.059081532,-1.6578057e-34,0.04691133,-0.017117519,0.047274295,-0.0010357625,0.035912234,-0.0040218667,-0.03485536,0.02150419,-0.04826284,-0.012232898,-0.03625382,-0.012712637,0.036915723,-0.041219804,0.025085874,0.02852731,-0.03492246,-0.108406164,0.08424019,-0.0022103398,-0.037863024,0.06429685,-0.046931196,0.032837044,-0.03667891,-0.0020163816,0.03513489,-0.026686063,0.013572029,0.009006773,0.08882453,-0.019383032,-0.08722235,-0.08127928,0.05808015,0.041702125,-0.06304245,-0.0028864245,-0.038101003,0.033409342,0.07742771,0.022429168,0.09874396,-0.024975026,0.024926592,-0.015399473,-0.07726724,-0.030138269,0.12556663,0.029315136,-0.042550012,0.0005271525,0.0656103,-0.001750788,-0.038549293,0.03978051,0.018791547,0.047560748,0.015418428,0.0635583,0.0574788,-0.018477494,-0.038121346,0.0045162714,-0.0048397714,0.037759356,-0.09109578,-0.017607093,-0.012043018,-0.030440303,-0.054391917,-0.09948751,-0.003959898,-0.0441019,0.0047097066,0.012532961,0.070832804,0.0558243,-0.031017214,0.04517326,-0.00944271,0.035291277,0.03980049,0.029672455,-0.08971223,-0.052834895,-0.03588548,0.033679876,0.0066388994,0.04299999,0.0034053233,0.06987791,-0.0074913036,-0.022508563,0.012274985,-6.3436875e-34,0.059285935,-0.004276918,0.028938254,-0.08751546,-0.019102583,0.0398734,0.009867812,0.042386245,0.01115911,0.001800492,0.008597225,0.045385424,0.081009164,-0.000605263,0.0035929203,0.061429612,0.031558704,0.07149677,-0.023357539,0.032438494,-0.046177715,0.08741536,0.0326066,-0.059303336,-0.05489056,-0.04269333,0.021507766,-0.017048478,-0.005526207,-0.081433006,0.08464916,-0.0013738397,-0.05088093,-0.040598724,-0.07199213,-0.06000657,-0.015620321,-0.079554334,-0.04317994,0.024829041,-0.074747905,0.058189828,-0.027432995,0.015013526,0.09516361,0.00015513248,-0.021425497,-0.025961991,-0.13495721,0.102499865,0.027204728,-0.035307374,-0.035665456,-0.032578513,0.046013854,-0.07851695,0.022081986,0.081140324,-0.0336283,-0.0063781035,0.048204225,0.04247798,-0.05048726,-0.040807392,0.08587312,0.11958455,-0.03736491,9.9621146e-05,-0.053544216,-0.05743883,0.0345007,-0.03394936,0.01748565,0.06828504,0.02300914,0.03823571,-0.02245215,-0.06988152,-0.07295779,-0.02191085,0.01893649,0.04156267,-0.01178933,0.0024707362,-0.042850297,-0.006891775,-0.0037066615,-0.07470068,0.023657134,-0.024300158,-0.004978354,-0.019585561,-0.022079775,0.05024655,0.080226995,-2.2998917e-08,-0.0026094862,-0.011698611,-0.030801643,0.023410201,-0.027816528,0.00066321203,0.016590457,0.039523937,0.0228299,0.03816584,-0.0030025518,-0.019262783,0.03204786,0.079822645,-0.0047322502,0.0011038687,0.034026057,0.04308273,-0.0016623901,0.061763577,-0.101095155,0.049709495,0.0056909723,0.020092946,-0.05434684,-0.09487664,-0.0017022719,-0.06852467,0.088120714,0.03871536,0.038289633,0.03695307,0.041552875,-0.04253346,-0.017311381,-0.0057352274,0.015293207,0.023678506,-0.043436717,0.014104324,0.06947396,-0.058765553,-0.017912168,-0.029978702,-0.0069742985,-0.03194391,-0.017791556,0.06782074,0.043205395,-0.0057138638,0.079210095,-0.022923144,0.08428092,-0.08100648,-0.09621169,-0.091425255,-0.03780704,-0.07292755,0.07706933,-0.022233224,0.00013939639,-0.010470218,0.054546468,0.09669029 +4.3.1.28,"Requires bound NAD+. The enzyme produces the non-proteinogenic amino acid L-pipecolate, which is incorporated into multiple secondary metabolite products, including rapamycin, tobulysin, virginiamycin and pristinamycin.",384,1.0,-0.02809731,-0.06713982,-0.07870537,-0.06418801,0.043179024,0.09140822,-0.06896554,0.13815074,0.06929705,0.004219388,-0.031222058,-0.011922517,0.005666603,0.044422366,-0.09463809,-0.005253468,-0.030019782,0.0057912273,0.016470985,-0.08523962,0.08866141,0.02860241,0.05452152,-0.0007003548,0.10830406,-0.015725283,0.026989784,-0.001491396,0.0095182145,-0.053451028,-0.008782443,-0.00753272,-0.031421244,-0.049290724,0.020877482,0.04740893,-0.031749934,0.0062859696,0.07931626,0.015948972,0.06454482,-0.032452896,-0.010620237,-0.067367256,-0.03142972,-0.02965728,-0.014819467,0.024946786,0.022484982,0.066594094,-0.07854568,-0.03479987,-0.016448997,0.04363446,0.02092472,0.010415732,0.006403797,-0.027638238,-0.016608663,-0.019768707,-0.000983023,-0.053372655,-0.013348403,-0.009599404,0.024114007,-0.05002465,-0.018166846,0.03104322,0.011114463,0.014676842,-0.0702904,0.024426125,-0.073033236,0.088675484,0.053884227,0.07265239,-0.037562635,-0.0028196194,0.01478062,-0.040599022,-0.026605131,0.029554218,-0.050260123,0.112082854,0.014975488,0.017060375,0.022531211,0.0968716,0.029657552,-0.012451172,-0.021910451,0.044655327,-0.016570086,0.024612138,-0.10083351,-0.06112583,0.03873271,-0.01943683,-0.006988799,-0.036333688,0.00012577622,0.035929482,0.022513777,-0.09809801,-0.045212198,0.033908036,0.01690649,0.05946715,0.00078181835,-0.0086955745,0.025037525,-0.014158929,0.053681266,-0.049144927,-0.047976788,0.085298374,0.07351269,-0.05917564,-0.14286573,-0.032006536,-0.04459879,-0.013437402,0.036389958,0.04391736,-0.049551018,0.009995586,-0.065793216,2.1301903e-33,0.046987828,0.024136487,-0.0063715572,0.039379027,0.04839437,0.07953247,-0.033722807,-0.060728267,-0.0026533094,0.007097931,-0.08028936,-0.05021702,-0.023500958,0.039875068,-0.0050072144,0.010766027,0.030408219,-0.05146989,-0.027720453,0.031288095,0.008805176,0.028159877,-0.009540291,-0.0039608283,0.005178188,0.04364216,0.034044504,0.03400732,-0.008414256,-0.0020280688,-0.019406294,-0.07091081,-0.0017493749,-0.028711284,0.051695418,-0.05302756,-0.0540194,-0.031185586,0.08216856,0.11067357,0.04558604,0.05167894,0.031021956,-0.027718408,0.027566755,-0.0700765,-0.03481445,0.085490815,-0.012835824,0.06935379,0.08872809,-0.038097177,0.06662919,-0.044097994,-0.031915344,0.02597062,-0.08342672,0.042132467,0.07526656,0.06719731,0.012690149,0.09038961,-0.014208211,0.1320346,-0.03296514,0.02160273,-0.0736043,-0.060835913,0.03187797,0.026578596,-0.053206593,-0.04592948,0.034872975,0.015033509,0.08260788,-0.080943204,-0.056132313,-0.032400202,0.07945039,-0.015661344,-0.032207146,-0.042456854,-0.061625704,0.004301947,-0.06650965,-0.010688325,-0.0026346806,-0.07783185,-0.01970144,0.075541556,-0.010760309,-0.037031867,-0.04347286,0.021628212,0.034698296,-3.373056e-33,0.1254606,-0.020379892,0.07816208,-0.094087325,-0.013993082,0.08438344,0.052956272,-0.17429076,0.04981861,-0.028842736,0.06724105,0.025339765,-0.03130578,-0.01773282,0.020224946,0.013927161,0.026987534,0.028754734,-0.0136532085,-0.04695491,-0.03256984,0.05028223,-0.005084734,0.021669894,-0.017669145,0.023197437,-0.055927284,0.06742157,0.0005787549,0.06271196,-0.009826285,0.0010661583,-0.064306095,-0.12596485,-0.017494187,0.029141456,-0.01821775,-0.00022078137,0.04682391,-0.002162077,0.009447809,0.013492624,-0.010777061,0.0054387855,-0.005359658,-0.003597151,-0.022970855,-0.0892331,0.008302601,-0.047905326,0.06270869,-0.001502717,0.0020385343,0.029399259,0.006117174,0.008171594,-0.02431962,0.02152592,-0.007005572,-0.054669354,-0.043906394,-0.06735548,0.008194284,-0.058214977,0.028413333,0.02376681,-0.02258355,0.008335631,0.10211016,-0.03654321,0.06894892,0.03422945,0.06108846,0.038170654,0.021164112,0.05950026,-0.09874051,-0.032832716,0.014182881,-0.0495365,-0.06630958,0.06974985,-0.08121996,-0.08559778,0.053421095,-0.06801369,0.025508244,0.02370905,0.022449868,0.04174145,0.030732242,0.008786116,-0.09211928,0.034371305,0.07779117,-3.8309672e-08,0.037395414,-0.014023958,0.012959411,0.013362888,-0.053725787,-0.0032072186,-0.02645759,-0.0053617135,0.057377726,-0.028306138,0.02342643,0.11977743,0.0045546945,0.038957708,0.054241374,0.0349059,-0.0658793,0.050353248,-0.062718086,-0.032930575,-0.088888,0.004730636,-0.10151174,0.029870905,-0.01668032,-0.09108392,0.00640315,-0.048768576,0.041967023,0.0011953949,0.08027209,-0.016114324,-0.008906796,-0.041705035,-0.027535884,0.04484411,-0.0734642,0.014745933,0.027028807,-0.027844248,0.03019799,-0.046820465,-0.06141326,-0.0068318862,-0.051077574,0.032257162,-0.03306688,0.018747877,-0.07666651,0.065140985,0.023081228,0.0066256914,0.03928965,-0.078458615,-0.054763965,0.04724829,0.032480333,-0.04127537,-0.025844116,-0.15224914,-0.020431004,0.034638997,0.21543232,-0.07178326 +4.3.3.7,"The reaction can be divided into three consecutive steps: Schiff base formation with pyruvate, the addition of L-aspartate-semialdehyde, and finally transimination leading to cyclization with simultaneous dissociation of the product. The product of the enzyme was initially thought to be (S)-2,3-dihydrodipicolinate [1,2], and the enzyme was classified accordingly as EC 4.2.1.52, dihydrodipicolinate synthase. Later studies of the enzyme from the bacterium Escherichia coli have suggested that the actual product of the enzyme is (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate [3], and thus the enzyme has been reclassified as 4-hydroxy-tetrahydrodipicolinate synthase. However, the identity of the product is still controversial, as more recently it has been suggested that it may be (S)-2,3-dihydrodipicolinate after all [5].",384,1.0,-0.02621183,-0.07036631,-0.086134434,-0.005926404,0.09862642,0.013022992,-0.08243967,0.05955279,0.031513933,-0.015514901,-0.037860375,-0.05107582,-0.05296654,0.011525125,-0.054815188,0.039034694,-0.072847046,-0.016815169,0.021024318,-0.041779283,0.01126107,-0.03273593,0.032349616,0.044314887,0.050522298,0.050356224,0.07824873,-0.024226181,-0.062010404,-0.04953066,-0.011487824,-0.025359694,0.024223592,-0.10306438,0.074349195,0.07707597,-0.040557005,-0.036889434,0.04382932,-0.0047479034,0.05274647,-0.020100601,-0.04475836,-0.025109865,-0.036382828,0.020358618,0.048827797,0.06883108,-0.01645349,0.017635347,-0.026209785,-0.043291975,-0.037477285,0.025587097,-0.018989064,0.007112008,-0.048592173,0.025228709,-0.019010859,0.007953398,0.034329932,-0.0135715855,0.0040110457,-0.03567683,0.028895356,-0.023657134,0.045215942,-0.13702668,0.053742312,-0.03540552,-0.10782193,-0.024534708,0.08700435,0.08574988,0.029040663,0.024301652,0.039950527,0.014366767,0.057251234,-0.09257905,0.029202515,-0.013560149,-0.030627472,0.016001994,0.014409404,-0.044650044,-0.032945868,0.006416205,0.0739746,0.011353672,0.01995305,0.048907198,-0.09199721,-0.07748926,-0.05648627,0.09669753,-0.03182001,0.075653836,0.06817528,-0.023205487,0.021968542,0.06843421,-0.018327717,-0.06599999,0.036598306,0.009617892,0.0062303487,0.1057437,-0.0024626893,-0.015254132,-0.0028588097,-0.017099671,0.06157661,0.012238094,-0.029767135,0.11852315,-0.011738593,-0.07918802,-0.028326297,0.018844664,0.11621578,-0.007917067,0.12027205,0.061767913,-0.021898896,0.047013137,-0.114150725,4.5015927e-33,0.04873409,0.06974556,0.014278604,0.02508893,-0.010707513,-0.0068775136,-0.062344223,0.07903983,-0.07538797,-0.020463413,-0.02180164,-0.12243144,0.10183892,-0.03433381,-0.03795084,-0.04981728,-0.034660812,-0.009171807,0.06302871,-0.015769824,-0.0012853208,0.05382332,-0.018940607,0.049990218,-0.031371392,0.043460686,-0.01673558,0.051994093,0.077443816,-0.005974415,-0.002537447,-0.10066313,-0.109742835,-0.031391602,0.07078748,-0.024534164,-0.02979381,-0.014861733,0.023564102,0.08945871,0.028346023,-0.028464708,0.050733697,-0.01817293,0.043853194,-0.009561332,-0.0725816,0.06220597,0.057017423,0.01579087,0.07596791,-0.050811887,0.13231866,-0.057556923,-0.050791137,0.044442166,-0.007228036,0.009827826,0.051504843,0.014495952,-0.02257541,0.1290718,-0.123445235,0.012808846,-0.04348254,-0.019420246,-0.00081890106,-0.03724773,-0.037002485,0.00064516015,-0.04374858,0.012262662,0.05493446,0.021100422,0.02983167,-0.055519566,-0.05397794,0.02497372,0.04050122,-0.02503101,-0.05735151,0.088286646,0.016511755,0.023086986,-0.062582806,-0.060990978,-0.043757316,-0.025219865,-0.011368362,0.08588805,-0.011846878,-0.05875675,-0.021470163,0.02770906,0.010841469,-4.5777265e-33,0.028908554,-0.059443973,0.010332221,0.0059723696,-0.09005403,0.089623995,0.015958127,0.002078319,-0.004347303,-0.08829464,0.11024031,-0.0046508843,0.046145614,-0.011801449,0.035980254,0.042573627,-0.050268013,0.046071578,0.0128249535,0.02433572,0.08233733,0.0423022,-0.021003814,0.04977422,0.061984662,0.032049507,0.099931665,0.012375886,0.11564419,0.08147606,-0.02191532,-0.054347143,-0.04475478,0.019283473,-0.035058226,0.006708701,-0.08369514,-0.07041062,0.020318167,0.05730944,0.006031535,0.034055013,-0.012267425,0.014120377,0.05397707,0.049495474,-0.036892455,0.058875624,-0.017622203,-0.008355328,0.019723132,-0.021291006,-0.14907575,0.015287731,0.0103926845,0.047672268,0.02500266,-0.0056804484,0.03960523,-0.050838664,-0.06333144,-0.09185319,0.0457315,-0.01978984,0.064624704,0.0363106,-0.032222975,0.07485088,0.048621114,-0.0107254945,0.047141355,-0.040614318,-0.047053825,0.013745618,0.032316048,-0.01849894,0.001331035,-0.026336417,0.012966857,-0.045532867,-0.0010169662,-0.029098429,0.04510132,-0.056942336,-0.0051093386,-0.09462734,0.01649635,0.118487015,0.018209849,-0.0107279755,0.033653,-0.0519902,-0.027092308,0.0621211,0.076714545,-4.9635524e-08,0.006169275,-0.0140929995,0.04504952,-0.021966306,0.06849415,0.02008756,0.03723241,-0.036591947,0.031552516,-0.057478104,-0.03438946,0.024838649,0.007889936,-0.013710595,0.017137043,0.00027185702,-0.07697068,0.044273034,-0.03848913,0.012915927,-0.04421001,-0.014065342,-0.14437585,-0.03600779,0.03553532,-0.10271687,-0.03976398,0.0026984452,-0.028807878,-0.05314518,-0.0246406,0.038917508,0.007144235,-0.02855964,-0.04511581,-0.019684596,-0.08388389,-0.019398537,0.037465505,0.04506714,-0.024419032,-0.0375006,-0.085969634,0.032536577,-0.03556846,-0.011844592,-0.036123447,0.012418066,-0.032791883,0.01048716,0.02092246,-0.03914485,0.04221546,-0.062207986,-0.0536834,0.0043858113,0.000969871,-0.085651435,-0.044112902,-0.090634055,0.021913901,0.041974183,0.11488889,0.004044595 +4.4.1.26,Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.,384,1.0,0.064338475,0.056353915,-0.11576539,0.015115408,-0.013769717,0.08289891,-0.07061911,-0.021264499,0.039931003,0.04119553,-0.025295982,0.03673243,-0.048090592,-0.04218969,-0.044502195,0.015649814,-0.012654793,0.04915681,-0.061979555,-0.011384816,0.051101387,0.12209744,0.025510339,0.034979887,0.000939615,-0.0030249883,-0.05093562,0.013396335,0.046730824,-0.06305913,0.017324762,0.05221156,0.0004523589,0.035880815,0.02287434,0.005179554,-0.056846056,0.027050348,0.11018118,-0.01532411,0.10274211,-0.019444568,-0.113271005,0.04283771,-0.04062501,0.028021293,-0.0065092063,-0.017380852,0.03637773,-0.06836568,0.029998561,-0.05369748,0.016769586,0.042734645,0.035324622,-0.001585723,-0.021063779,0.114130825,0.055821303,0.069694676,0.039720926,0.005765388,-0.009363122,0.015169058,0.04643591,-0.044086233,-0.07570897,-0.026838737,0.06064302,-0.11290597,0.03040772,-0.082773805,-0.018482419,-0.047922805,-0.057304382,0.054807372,0.023089906,0.013563107,-0.045004662,-0.066868536,0.059624925,0.0657867,0.0035376628,0.039572127,0.04112301,-0.07568856,-0.025867824,0.03658317,-0.0013486781,-0.0076124733,0.062677376,-0.01367536,-0.05006008,-0.043527994,-0.036373086,-0.011619335,0.1042302,-0.06596383,0.002046192,-0.044726416,0.020368585,0.0594638,-0.0603241,-0.09377697,-0.024125936,0.015010955,0.020464187,-0.07098343,-0.014773328,-0.013437468,-0.0020173287,-0.04187727,0.030391427,0.040304665,-0.04721235,-0.012694933,-0.04091794,0.028932495,-0.005775883,-0.066698715,-0.067138135,-0.0037438348,0.02616014,0.04955276,-0.046043437,-0.08155247,-0.058385402,-7.4438345e-34,-0.027405899,0.05321484,-0.036085848,-0.019155331,0.060116295,-0.09183374,-0.024066398,-0.019693797,0.02107444,-0.010654993,-0.016335424,-0.076373115,-0.049725637,-0.013060175,-0.024329735,-0.061281875,-0.087674215,-0.001197755,0.052853942,-0.037307754,-0.14953575,0.029014476,-0.17043237,0.027584193,-0.062495407,-0.007097114,0.03312254,-0.0427159,0.041348603,-0.028777901,-0.023851834,0.038571816,-0.043301664,0.033354964,-0.005046348,-0.0006287331,0.109482184,0.004222828,-0.056947656,0.027110804,0.029709263,0.031909168,0.02846553,-0.0009129888,-0.013705617,0.06256561,-0.106655344,0.029767245,0.100558884,0.07630935,-0.018628893,0.0007273324,0.1293942,-0.0350207,-0.05791745,-0.026550122,-0.036403675,0.013230454,0.023994958,0.055792477,-0.039944697,-0.016812664,-0.06140186,0.03318516,0.018788712,-0.019750891,-0.12342899,-0.0609378,0.056726046,0.03893247,-0.07687894,0.049491815,0.0199109,0.0027787508,-0.028606705,0.024146369,-0.055855814,0.062489763,-0.029783837,0.028678577,0.010969673,-0.04425344,-0.08521835,0.013506684,0.012361162,0.00097167917,-0.0009148633,0.0033585392,-0.030196926,-0.040934727,0.01444179,-0.022513531,-0.006841173,0.004442128,0.06415078,-1.2492445e-33,0.1087127,-0.05254976,0.08670754,-0.008711458,0.042145893,0.0805394,-0.05396924,-0.019299243,0.02328279,0.04752169,0.04770115,-0.022544332,0.104995705,0.013981924,-0.023534978,-0.022696907,-0.011190724,0.09575166,-0.09564481,0.053076316,-0.07257681,0.032448485,-0.045929134,-0.0011662347,-0.022943443,0.047624357,-0.027202995,0.05885356,-0.03735648,0.10118288,0.102181725,0.096689485,-0.14717273,-0.015238321,-0.038115676,0.03777834,-0.0036321238,-0.005538894,-0.08684279,-0.005691173,0.025030686,0.05607156,0.049898744,0.055843133,0.06840745,0.010256718,0.042819947,0.037360027,-0.013533376,0.012615481,0.059247717,0.047760487,-0.012687845,0.08487837,0.07518821,-0.015408572,0.017543482,-0.049656123,-0.018870153,-0.11129674,0.0021213642,0.05422328,-0.03400142,-0.08740363,-0.028259216,-0.030908994,-0.0004397302,0.04225042,0.0587797,0.05072138,0.030442916,0.007761229,0.08588501,0.08976784,-0.03618868,0.040311217,0.053389877,-0.0935707,-0.022406725,-0.012395301,-0.025749808,0.038441356,-0.01561016,-0.04244709,0.08752824,0.021231588,-0.041552763,0.06362624,0.008410594,0.010988769,-0.034240983,-0.0036092233,-0.07541032,0.031447407,-0.016005462,-2.1507633e-08,-0.010946551,-0.05565075,-0.015863726,-0.022070397,-0.0007911545,0.030204436,0.03523511,0.045916736,0.013329628,-0.09546849,-0.02480251,0.014876697,-0.03167965,0.028786538,0.058822643,0.02344161,0.0079058325,0.06808498,0.021305535,-0.006701403,-0.09849648,-0.08088037,-0.005973175,-0.007175143,-0.015216721,-0.00674301,0.012406796,-0.021533081,0.019824168,0.00941408,0.11862251,0.0030563043,0.006397599,-0.010439154,0.015688451,0.005276027,0.042240985,0.04513024,0.027217422,-0.046266463,-0.02856622,-0.066289365,-0.059559118,0.038112894,-0.054080512,-0.0645578,0.01999511,0.086596325,-0.024361055,-0.027398977,-0.046634298,-0.007904379,0.061743557,-0.06250924,-0.052216567,-0.044973947,0.024591038,0.02715023,-0.03967716,-0.053690895,-0.028407432,0.07281048,0.13090701,-0.031250704 +5.1.3.25,The equilibrium is strongly towards dTDP-beta-L-rhamnose.,384,1.0,-0.019339187,-0.111750506,0.049711756,0.015201649,0.024290575,0.046536725,-0.009959096,0.09431704,0.013154896,0.07794368,0.00748389,0.043626945,-0.0761953,0.0025600854,0.035702657,0.031490114,0.0054950938,-0.016014451,0.03352033,0.085452855,-0.018540652,-0.029085925,-0.023427231,0.03443827,-0.013714981,0.0016806376,0.062135983,-0.0054661813,0.025617989,-0.07395548,-0.028884875,-0.026351867,-0.00128711,-0.012379759,-0.07236659,0.020455725,-0.056389052,-0.06805436,-0.028280262,0.056999527,-0.009452033,0.020090189,0.034525577,-0.048100766,-0.026500447,-0.050700035,-0.075875156,0.042058922,-0.015376195,-0.027369365,0.024089206,-0.024280986,0.004716063,0.071308576,-0.037142638,0.022889696,-0.06458167,0.062081035,-0.026553903,0.07485217,0.058400407,0.06878963,-0.061068434,0.028498588,0.099723816,-0.003911559,0.012542709,0.034116108,-0.02924448,0.025642868,-0.048810653,-0.003610911,-0.035099532,-0.13023487,0.050157487,-0.0040542665,0.0046653235,-0.03655451,0.039573945,0.00070780556,0.06615693,0.06624665,-0.042752594,-0.065739915,-0.0698599,-0.027173655,-0.014529276,0.04258343,0.03128731,-0.019591762,-0.0023766344,0.012832438,-0.12795141,0.0029161703,-0.03678793,0.013037614,0.050689727,-0.008037958,0.029737724,-0.020060416,-0.05860659,0.045934916,-0.055259474,-0.019735945,-0.08185377,0.0031692574,0.024003388,-0.05189224,0.04434173,0.058495898,-0.019546272,0.06396177,0.020668354,0.07669445,-0.10391205,-0.0870989,-0.024754662,-0.03856047,-0.07920069,-0.082309276,0.018548137,-0.06611463,-0.07848009,0.031364787,-0.042869475,0.018121462,0.0004809458,-3.2138765e-33,0.118309185,0.0034007616,-0.018591126,-0.03602248,0.004495119,0.030005682,-0.09810849,0.0006320323,-0.02552662,0.04191437,-0.08202786,-0.018608304,-0.07663648,0.00383279,-0.08680412,0.023491155,-0.053099442,0.08868664,0.07267376,0.03688056,-0.0169865,0.030864477,-0.08068525,-0.01735877,0.02663992,0.03126582,0.0020169986,0.032667853,0.012035145,0.010546921,0.0049265656,-0.0044956035,-0.051438477,0.04493629,-0.054304637,0.03801559,-0.1399045,0.01284083,0.0052605295,-0.017648127,0.07527695,0.021716831,-0.040920217,0.044060405,0.012189447,-0.027180035,0.04081156,-0.086783655,0.0073698456,0.052387767,0.030343723,0.024374727,-0.059528947,-0.023155231,0.027072713,-0.04867163,-0.10221887,0.017589169,-0.022388782,0.08225246,-0.012599685,-0.019000413,0.04740352,-0.123810984,0.0030559327,0.087838635,-0.034884185,-0.048303466,0.012434634,-0.049018826,0.034093123,-0.031846948,0.11418928,-0.019435434,0.037224073,-0.024074564,0.04390661,0.025316501,0.0727824,-0.0076359473,-0.06578089,-0.013941453,-0.016197741,0.005424597,0.010616669,-0.05496576,-0.012075955,-0.013447418,0.012649646,0.04305385,-0.041807026,-0.057897538,-0.0071022566,0.032717664,0.0759397,-1.1383882e-34,0.029064693,-0.078636624,-0.069539055,-0.030216163,-0.020587528,0.00045144928,-0.003275068,0.042733766,-0.005864282,-0.021893678,0.07966279,0.04727654,-0.093317375,0.0033482972,0.057449736,-0.013342254,0.05784174,0.06267086,-0.023706337,-0.05186706,-0.019434147,0.027184295,0.029749747,0.1245852,0.0124558555,0.0010531989,-0.005816831,0.030687949,0.038375434,0.09084716,0.028360048,0.047524933,-0.05579843,0.027421141,0.0017243754,0.10340091,-0.053292852,0.050128803,-0.022635814,0.09610202,0.010982054,-0.020897798,0.048973914,-0.047300417,0.09390809,0.040202513,0.003345667,-0.089230165,0.04097511,0.0051918477,0.07200263,-0.0050393525,-0.0067684255,0.0008166662,-0.031562164,0.090564296,-0.068030216,0.049623713,0.022324165,-0.093086176,-0.047940735,-0.033663232,-0.07340716,0.006764188,-0.08259164,0.033768542,-0.013628668,-0.017895881,0.12150614,-0.022537978,0.048345566,0.0333728,0.09898903,0.034050085,0.005440084,-0.08126327,-0.047457587,-0.10359246,0.02728888,-0.025345119,-0.061813235,0.11831296,0.021122053,-0.037587136,-0.041133814,-0.07781084,-0.022090467,-0.03585405,-0.03886848,0.028460857,0.0023949507,-0.014713032,0.01709616,0.008794584,0.15686764,-2.3307887e-08,0.16026741,-0.025101783,0.018661473,0.056801435,-0.0012107472,0.052116226,-0.0058363113,0.04946399,-0.016635839,0.045313563,0.033655927,0.111182645,-0.007927752,0.007989682,0.036974803,0.016956769,-0.094807126,0.054146882,-0.048485868,-0.017552532,-0.004762751,0.036434647,0.0075903465,-0.03499522,-0.0026482313,0.038401064,0.058920633,-0.03721733,-0.04068526,0.027452905,0.07601875,0.03417012,-0.055284515,0.046414062,0.030039376,-0.032864615,0.007785531,0.05881393,-0.04338693,-0.024903685,-0.037965827,-0.025128413,-0.021899668,0.033145,-0.064897574,-0.0050142054,-0.01652557,0.0844203,0.059806556,-0.011766969,0.0088825645,-0.014505646,-0.063077606,-0.120895825,-0.060614828,-0.044906445,-0.069648765,0.043465316,-0.070765,-0.09899559,-0.042433474,0.0092038615,0.047966927,-0.061730325 +5.1.99.6,"The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate. Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC 4.2.1.93, ATP-dependent NAD(P)H-hydrate dehydratase.",384,0.99999994,-0.039378926,-0.0027235495,-0.036408663,-0.07098967,0.030313732,0.07615844,-0.029289598,-0.0065628537,0.006177516,0.039123904,-0.039567705,0.023737531,-0.103549875,0.10536193,-0.002353991,-0.025947325,-0.053621203,0.031013014,0.057956982,-0.058083154,0.07304699,0.0053680046,-0.0062292744,-0.028574912,0.04075634,0.055924974,0.067188285,-0.002300788,-0.008259402,-0.06861798,-0.051072054,-0.0392995,0.0295725,-0.08654228,-0.016275983,0.07973004,-0.07592951,0.008629111,0.011410059,0.036114715,0.04634979,-0.0070744543,-0.03248253,0.041641515,-0.07218543,-0.0521435,-0.0034395957,0.1104492,0.012046505,0.0563057,-0.0014233469,0.02789766,0.014658516,-0.042036608,0.01886829,0.06337083,-0.029648773,-0.028711734,-0.09055161,-0.11648995,0.030782174,-0.047828812,-0.013210737,0.02858268,0.07718371,-0.0386147,0.07954296,0.0009220711,0.04317664,-0.014650262,-0.09626037,-0.04703266,-0.010782474,-0.022276705,0.0039197137,0.035171524,-0.008749739,-0.03314166,0.06416626,-0.0015347163,0.0608501,0.06895223,-0.029999094,0.060364638,0.062164318,0.037460946,0.022350483,-0.03257512,-0.010253173,-0.053569134,0.03504404,-0.025029235,-0.024536677,-0.032798313,-0.18035,0.00059927173,0.025104037,0.07974164,0.03900177,-0.05831886,0.05851114,0.114286356,-0.040620293,-0.05080844,-0.039483495,0.04257429,-0.040423043,0.12199388,0.013193375,0.022976972,-0.04614803,0.0020019072,0.002300187,0.036133178,-0.05851229,0.06953055,-0.088520974,-0.031876553,-0.107345164,0.024013737,-0.029174441,-0.026380688,0.028378302,0.0071492773,0.017220246,0.021649173,-0.1220275,-1.7277089e-33,0.08300277,-0.0066598793,-0.010258746,-0.016290095,0.02344294,0.013580445,-0.058365695,0.052019294,-0.08220831,-0.017330088,-0.01934467,-0.066540785,0.07673486,0.008425503,-0.03844849,0.043266974,-0.019774728,-0.010874197,-0.03747326,0.05363081,0.044404972,0.12952949,0.008692982,0.03311885,0.0058679353,0.023835603,-0.015068544,0.07388687,0.062414754,-0.0013349394,0.016942583,-0.14500089,-0.06055688,0.003881754,0.08272851,-0.066607006,-0.04567716,-0.03388465,0.017695019,0.08132566,-0.010689468,0.019865995,0.050931588,-0.018104222,-0.00010860214,-0.07866643,0.015921082,0.09035098,0.024965549,0.035210613,0.08002256,-0.06472417,0.09601638,-0.051105402,-0.023002176,-0.018566811,-0.07695421,-0.020467035,-0.023882004,0.026872883,0.026365377,0.00072420767,-0.025467375,0.042948384,-0.0035825195,0.02591759,-0.06866962,-0.10727717,0.028011609,0.055022787,0.0008347612,-0.005357378,0.044680998,0.046542086,0.0003423405,0.0010216228,0.009821521,-0.032863215,0.038582962,0.03058801,-0.042910438,-0.01420056,0.013985803,0.03825654,-0.0012527514,-0.056829724,0.031774294,-0.09780076,0.041400623,0.030221557,0.032402135,-0.07318505,-0.057306506,-0.10578779,0.081154436,-7.3435304e-34,0.103862375,-0.022135409,-0.02885325,-0.09288915,-0.07326499,0.08331532,0.06442111,-0.077501684,0.052755162,-0.06478007,0.027796907,0.046925887,0.015215754,-0.050510246,0.03654465,-0.015779912,-0.023994083,0.030295284,-0.06384784,0.015721582,0.0135797905,0.08668201,0.06907201,-0.026972536,0.061947767,-0.08406635,0.0060635554,0.055410065,0.06508677,0.027249513,-0.049732063,0.008942458,-0.02779328,0.03478895,-0.00088062766,0.039348383,-0.0526028,0.00031992243,-0.063867904,0.066336036,0.00059882185,0.020294743,0.022539452,0.022500146,0.060146295,0.019170333,-0.0849749,-0.0109064,-0.031031506,-0.06830983,0.09412585,-0.045635168,-0.011864814,0.026376218,0.04675446,0.039130215,-0.013880565,-0.022979625,0.0477306,0.03633176,-0.024588788,-0.061945003,0.022278655,-0.022280125,-0.013678727,-0.036571316,-0.017172016,0.04099158,0.0060047037,-0.022405019,0.060999755,0.019187251,0.04601685,0.09005,0.0141615225,-0.032216825,-0.118731454,0.008125906,-0.00874478,-0.05798784,-0.07176334,0.023758842,-0.05977211,-0.06860116,0.028822958,-0.010054924,0.04349705,0.042335756,-0.028056905,0.032263767,-0.008477252,-0.00032201392,-0.045358606,0.081359535,0.027176691,-3.9285e-08,0.03971798,-0.017093495,0.03539153,-0.029933807,0.009940055,0.042998914,0.04863925,-0.039434966,0.043364502,0.015705798,-0.022153964,0.058596972,0.050445545,-0.011884237,0.059771717,0.037407655,0.014914639,-0.003162338,-0.09945577,-0.05780547,-0.096246205,-0.024478348,-0.1556371,0.08185641,0.04875188,0.005985328,0.053998332,-0.012825426,0.00089629804,-0.08835085,0.029383821,0.0047393553,0.079470366,-0.021700598,-0.023227984,0.010269009,-0.0210982,0.05126669,-0.040700335,0.07566563,-0.004472013,-0.046054978,-0.045584887,0.047565635,0.0048509478,0.020833593,-0.034897488,0.043408595,-0.047868732,-0.002462601,0.0032989571,-0.014788376,-0.05861003,-0.10652591,-0.050143488,0.016063172,0.00040679684,-0.0759756,-0.014993116,-0.0347909,0.031357955,0.033537794,0.12080504,-0.07777685 +5.2.1.14,"The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza.",384,1.0,0.01897327,-0.024108576,-0.13369982,0.0707162,0.010482041,0.11648858,-0.041199327,0.027543237,0.003021825,-0.009886394,0.01551799,0.0025632523,-0.07155649,-0.05418746,-0.058917977,0.022561638,-0.06328452,-0.00791306,0.013332028,-0.05479227,0.0883518,0.056720573,-0.010088708,0.00030553227,0.05806597,-0.026542101,-0.026699608,0.0008742321,-0.08088354,-0.07751645,0.01719159,-0.03155279,0.11580757,-0.028520312,0.031913422,0.1158627,-0.03698342,-0.122214876,0.06304209,0.036803544,0.048859894,-0.0935742,-0.02384896,0.010226968,-0.0875178,0.017976888,0.0429844,0.06635887,-0.06111085,-0.015892426,-0.0756556,-0.09342569,0.0026478216,-0.028195081,0.016908173,0.0629216,0.037671804,0.034063056,-0.02072469,0.012105802,0.056413654,-0.005733902,-0.026017224,-0.01667308,-0.05142446,-0.01822973,-0.02700572,0.021048097,0.060320023,-0.020659542,0.031675693,0.021493679,-0.1298522,0.04360872,-0.03767084,0.042960085,-0.09291539,-0.016503366,0.034281634,0.026428279,0.00617032,0.0392205,0.01624424,-0.006255027,0.028041305,0.020838274,0.0053691375,0.043527074,0.015460796,0.0673226,0.021980582,-0.09059704,-0.039299563,0.061791986,-0.068317525,0.03079241,0.06891329,-0.10384475,-0.038489114,-0.04689294,-0.022925137,0.009992464,-0.009625492,-0.0061062947,-0.018436693,0.056853503,-0.08177871,-0.021420749,-0.0018873183,0.004210015,-0.06617326,0.019058764,-0.019326143,-0.0026871257,0.017199041,0.1257975,0.057880905,-0.025038484,-0.045474246,-0.03222057,0.009846249,0.034049127,-0.02832003,0.07121085,-0.05375524,0.010905504,-0.073749095,1.0326546e-33,0.031873815,0.012248749,-0.02069898,0.0063531194,0.0056126197,-0.024062552,-0.06999482,0.026680958,0.0031181371,-0.017139299,-0.067638464,-0.058974616,0.046140224,0.0392757,-0.0027050197,0.005396441,-0.002412386,0.022584716,0.12511867,0.0361571,-0.015614324,0.014247257,-0.0932934,0.02210016,-0.04419993,0.044973813,0.050301343,0.013388811,0.09134406,-0.0016073274,0.10162696,-0.09564353,-0.03960657,-0.048209824,0.08619406,-0.06422152,-0.0925901,-0.07106968,0.006357372,0.04368961,-0.0077840486,0.014732641,-0.005776467,-0.040616844,0.051202487,-0.015351636,-0.037883993,0.0018874985,0.04660109,0.092454,0.064264216,0.06218913,0.17582586,0.07746181,0.0063265166,-0.016339157,-0.015617288,0.035368886,-0.023252333,0.0036447186,0.015496977,0.012133463,0.01977846,0.03860266,-0.012084475,0.06463597,-0.054546293,0.018903138,0.014879855,0.12248005,-0.06137188,-0.05201281,-0.07926466,-0.035258748,-0.006836636,-0.012937729,-0.08730066,0.025127353,-0.034783207,0.01213969,-0.056626156,-0.018130898,-0.062118545,-0.008551235,-0.06003917,0.037025217,-0.01952271,-0.03461798,0.033253513,-0.03083267,0.03624325,-0.020523874,-0.047599185,0.0684964,0.073186755,-3.292302e-33,0.070652515,-0.09415834,0.06047904,-0.017464926,-0.046904076,0.07546916,0.023478867,-0.06920541,0.013574025,0.057708323,-0.037469607,0.027882181,-0.04679555,-0.058047343,0.032134615,-0.031895515,-0.0056139794,0.0767806,-0.0012222497,0.01212825,-0.06986576,0.14097385,0.008123596,-0.03977451,0.06163863,-0.0560573,0.010793671,0.007056756,-0.0033616326,0.030074384,0.098055534,-0.075740784,-0.043754395,-0.07199993,-0.041652218,0.043463517,-0.076076284,0.0042747967,0.07932127,-0.0016929992,0.030525133,0.04313668,0.027167121,0.032247983,0.03741537,0.04996293,-0.11138108,0.039624665,0.008878793,0.0058595766,-0.0289214,0.035981663,0.0098008085,-0.0288535,0.06621134,-0.09034451,-0.016832286,-0.05184097,-0.06080217,-0.059225515,-0.04785368,-0.028084697,-0.0011656411,0.011895387,0.014490264,-0.018796232,-0.0087556075,0.022325806,0.04439496,0.0019510008,0.070554145,0.046440747,0.0018596586,0.12991692,-0.010934447,-0.04472369,-0.044396363,0.03936797,-0.044665355,-0.022348985,0.00523456,-0.032891285,0.051491134,-0.09720101,-0.027017908,-0.09627453,0.04700011,0.0835423,0.029006135,0.08670603,-0.014148857,0.056499172,-0.0322066,-0.0025996051,0.052035913,-2.6184045e-08,0.0186405,-0.013500746,0.024611184,-0.042847537,0.023314832,-0.04843412,-0.006006131,0.069379315,-0.0009921081,0.026889872,-0.0031062728,0.027149217,0.061910275,0.029407429,0.030863062,-0.03554395,0.011282691,-0.03489665,-0.0044608684,0.037673444,-0.07725175,-0.010759111,-0.08437014,0.058217246,0.020896355,-0.08330794,0.05856319,0.025518997,0.06579412,-0.00928665,0.11800544,0.016189247,0.06505017,-0.01661289,-0.10975232,0.074966826,-0.029853819,-0.012282501,0.040229596,-0.0093505625,-0.046818834,-0.06793609,0.028431116,-0.017895566,-0.08182726,0.05398944,-0.00759982,-0.020455817,-0.023414325,0.033981767,-0.05539517,0.023981804,-0.025314655,0.005078494,-0.06115911,0.03542912,-0.013144177,-0.02041525,-0.017037261,-0.06370832,-0.005907692,-0.0012532884,0.10341345,-0.07144962 +5.4.99.58,"The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases.",384,1.0,-0.002837718,-0.054042943,-0.12470032,0.007892529,0.09227573,0.0772135,-0.0919501,0.037950836,0.059470244,-0.027182724,0.007395418,-0.0033531538,-0.018652163,0.041641403,-0.033056784,0.07509207,-0.15243225,-0.0018610095,0.026066627,-0.07381045,-0.0043884423,0.031892076,-0.013228492,-0.026986046,0.029445918,0.021890791,0.0908695,-0.04589451,-0.059513427,-0.0056905444,0.03511142,-0.041211404,0.039004777,-0.014748339,0.04135398,0.15584886,-0.037189417,-0.013235195,0.050367493,-0.00045103178,0.026476743,-0.0024720244,0.02901226,0.0018898557,-0.06145834,0.015094998,0.04145862,0.009456694,0.029671216,-0.03438965,-0.007511623,-0.03826534,-0.068712085,0.021333784,0.034342654,0.07726813,0.009303072,-0.027367251,-0.006349279,-0.020440964,0.13019507,-0.05414347,-0.032698903,-0.020820808,0.008026556,-0.0059417146,0.08997226,-0.051916014,0.057195183,-0.082252756,-0.062354255,-0.02061744,-0.02076432,0.038337816,-0.012876021,-0.0031512363,-0.013451044,-0.041368283,0.044354193,-0.060897656,0.050353754,-0.005627878,0.007898907,0.024163656,0.096813075,0.0026782306,-0.028460642,-0.023528952,0.056238048,0.016122892,-0.01820879,-0.025747288,-0.01826098,-0.039153174,-0.04997002,0.012994718,0.045877025,0.015897023,-0.019381648,-0.012247505,-0.007796468,0.08502865,-0.11953274,-0.034318816,-0.07085063,-0.045226574,-0.0039257375,0.07919346,-0.04892597,0.011101022,0.0019961556,0.063288525,0.06551397,0.0016189981,-0.024981122,0.0510882,0.062220667,-0.05008623,-0.061805513,0.038364466,-0.00036321732,0.08023357,0.07928949,0.09285061,-0.014678254,-0.021582939,-0.14386673,2.5685125e-33,0.089459516,0.07029028,0.055101257,0.012073071,0.045060545,-0.021540938,-0.07192867,-0.017727826,-0.035491854,-0.021320773,-0.056948125,-0.105173066,0.062266164,-0.024055723,-0.08596536,-0.050875742,-0.04623328,0.007936743,0.052132364,-0.038813803,-0.09120616,0.040729478,-0.060845394,0.050757833,0.0011227503,0.038605265,0.0053897724,0.03550633,0.06405586,0.02082847,-0.06993343,-0.029766794,-0.1398731,-0.045848224,0.04061241,-0.03387954,-0.05312528,-0.10018356,0.025194379,0.050142925,-0.045827754,-0.022429537,0.010495085,-0.051748395,0.039632518,0.004542052,-0.047158487,0.073036596,0.01930188,0.0820615,0.04081636,-0.07391394,0.12932223,0.006037701,-0.12808812,-0.038217943,-0.06623541,-0.087050386,0.002191959,0.08408596,0.057005107,0.031315453,-0.046593178,0.031958394,0.011115283,-0.00739262,-0.00027979215,-0.05931413,0.011723533,0.104273096,0.008885298,0.012879827,0.08772259,0.062408786,-0.0025737975,-0.012832361,-0.058336705,0.048123408,-0.015953002,0.0034229024,-0.07119563,-0.023887478,-0.005145295,-0.04267322,0.0002437302,-0.033141773,-0.023774777,-0.08337541,-0.012972909,0.015480192,-0.024404522,-0.043861084,-0.027308246,0.046671394,0.010086944,-3.3083297e-33,0.00776954,-0.008654381,0.006947292,-0.0638559,-0.06391031,0.044433948,0.013454406,-0.0035054279,0.026618684,0.00052546733,0.070499696,-0.034352668,0.011865126,-0.10282151,0.08319441,0.008585515,-0.00047903927,0.026176125,0.036241807,0.038285814,0.051225007,0.010784541,-0.0070560854,0.041713186,0.09360501,-0.002017685,0.0062379837,0.0707687,0.040187906,0.067468464,0.028457372,0.0036536646,-0.04746145,-0.027454322,-0.03409463,0.06011272,-0.05167511,0.02049125,0.029609418,0.0035985874,0.060102068,0.07402308,0.008989474,0.13286562,0.02285483,0.050741237,-0.032703154,0.08185457,0.013622879,-0.10912746,0.0011681211,-0.031639658,0.050623897,-0.035531823,0.03996778,0.043860435,-0.008879736,0.008252639,-0.012832488,-0.032970157,-0.04862314,-0.10037266,0.024722876,0.03962756,0.05502238,-0.017062107,-0.041037742,-0.0040315567,0.013773093,0.039848387,0.0510929,-0.017121045,0.027902404,0.095382154,-0.0626247,-0.023300717,-0.047074612,0.0039860625,0.009761503,-0.014107553,0.004547447,0.008790976,0.058453538,-0.13396491,-0.029815847,-0.0959137,0.08326527,0.11936448,0.04666028,0.0027148274,-0.048287004,0.010540694,-0.009450656,0.018458735,0.0286745,-4.191993e-08,0.058228225,-0.06497319,0.043544456,-0.053381883,-0.036488347,0.060638234,0.033374947,0.027644994,-0.00086599105,-0.008318499,-0.029872565,0.029228743,0.006927925,0.004929038,0.024117867,0.050319694,-0.05251084,0.015201212,-0.031189568,-0.0038848047,-0.0662599,-0.0010897305,-0.095350355,0.018518452,0.013706272,-0.0012883613,0.020734059,0.041866727,-0.009511017,-0.035065364,0.07707448,-0.03889906,-0.0051430403,-0.005806059,-0.14062773,0.0075036488,-0.079565085,-0.045813195,0.023016913,0.033905186,-0.037066873,-0.03833894,-0.023090327,0.056594096,-0.06853526,0.03092494,-0.039005227,0.015046807,-0.018578637,0.03016541,0.044094495,0.0044094725,0.011385949,-0.059132904,-0.10205472,0.0039131907,-0.026651673,-0.024514195,0.026685061,-0.093141146,-0.026520183,0.0270543,0.11944739,-0.01142869 +1.1.1.344,The enzyme works equally well with NAD+ and NADP+.,384,1.0,-0.07341006,-0.009158057,-0.067226864,-0.031377997,0.0090808,0.042846,-0.117355786,0.04689753,0.00842058,0.010401549,0.0031136435,0.015200032,-0.08984494,0.074798815,-0.022005726,0.029797267,0.01813767,0.030409412,0.069071256,-0.057111494,0.036057636,-0.05108721,0.06257947,-0.025482967,0.11585088,0.023442117,-0.009416361,0.027346656,0.015923176,-0.06322059,-0.046588134,0.013187215,-0.04272182,-0.08338796,-0.05838848,0.06782784,-0.08174913,-0.022085069,-0.044664808,-0.033014175,0.037672088,0.02762136,-0.05080309,0.001930872,-0.035367798,-0.062578626,0.0081123,0.05526453,0.079007834,0.017369097,-0.058050506,-0.036986962,-0.006919555,-0.015366076,0.021997664,0.0257648,-0.045550328,-0.0024219838,-0.026059287,-0.08180005,-0.023500813,-0.05442068,-0.050502073,0.026593687,0.096226834,-0.03768522,0.050344057,0.013782821,-0.06053448,-0.0282488,-0.14342386,0.013204983,0.017666413,0.049732666,0.0045552077,0.036750577,-0.06616927,-0.04665942,0.065464385,0.06911861,0.024882419,0.037857123,-0.07302772,0.05644103,0.11204556,0.063570164,-0.0008733706,0.012727693,-0.008727289,-0.011543625,0.035030283,0.048446734,-0.03532001,0.04097449,-0.116350956,-0.0052002226,-0.0026508616,0.051993582,-0.032369778,-0.06277311,0.009382291,0.0678744,-0.024810327,-0.09836733,-0.03354226,0.013695289,-0.014447877,0.083521865,-0.011746742,-0.0031608462,0.021670258,0.026579203,0.041356917,-0.005253304,-0.04555037,0.13335532,-0.020237708,-0.018373515,-0.086426266,-0.009229624,0.017186547,-0.018947855,0.024003882,0.049053304,-0.019440616,0.047876634,-0.03216836,-1.1782218e-33,0.063141234,0.028880283,-0.02850073,0.0024108975,0.028572477,0.069790676,-0.101071864,0.051401988,-0.048072726,-0.024653403,-0.07730979,-0.12992693,0.044681676,-0.026168095,-0.0031791227,-0.016307693,0.0015878575,-0.02182691,-0.033125393,0.01634488,0.07548796,0.045561027,-0.010305938,0.04060847,0.07452507,0.041999858,-0.014391724,0.08738691,-0.025883252,-0.012889321,0.048973955,-0.081069864,-0.11976632,0.013291892,0.040933285,0.046259157,-0.05921207,-0.06826688,0.01553715,0.028948301,-0.10566512,0.051239423,0.01705341,-0.048374217,0.06575208,-0.10825906,-0.028477712,0.07712941,0.031008208,0.06618218,0.06828939,-0.004970569,0.088541254,-0.039391592,-0.045424715,0.08133774,-0.014917247,0.04566164,0.0020763695,0.086026065,-0.022268156,0.014921847,-0.00723643,0.02878629,-0.06743003,0.06491504,-0.10477676,-0.052899566,0.020363437,0.07983643,0.022936404,0.07482129,0.07566373,0.05227717,0.003570162,-0.03843213,0.017448537,0.02147598,0.06610093,-0.00021579523,0.026195731,-0.012914942,-0.047966372,2.708399e-06,-0.0594974,0.01063859,0.007901573,-0.00511028,0.014342054,0.04341502,0.06782446,-0.040468022,0.017420718,-0.04618695,0.018185103,-2.5966647e-34,0.09755313,-0.06089574,0.08776641,-0.049343266,-0.037313454,0.11612253,0.0575895,-0.15373923,0.007474952,-0.027031364,0.05829148,0.020838818,-0.04707313,-0.008138819,0.014824559,0.0051185247,-0.056676563,0.002861879,-0.009914683,-0.006307833,-0.03350656,0.1684432,0.029757096,-0.024982478,0.063866735,-0.051614467,-0.06891576,0.073149204,0.017819453,0.028199436,-0.006206192,-0.028776987,-0.120779864,-0.060400926,0.0015264329,0.058251746,-0.024307586,-0.011040787,0.007426072,0.06445942,0.001432609,0.012896282,-0.08664573,0.042280097,0.019070493,0.029913856,-0.07815446,-0.04431194,0.011539364,-0.06711361,0.02222374,0.047424115,-0.07796682,0.005420475,0.05434244,0.017292045,0.03274006,-0.012585239,-0.003405946,-0.013234041,-0.086298056,-0.037388295,0.037315648,-0.010721763,0.04369557,0.04231761,0.010496993,0.02802269,0.044598702,-0.03742597,0.052855954,0.04320089,0.030258365,0.051251676,0.022811146,-0.037497755,-0.045403015,0.016480695,-0.012122966,-0.02522125,-0.039234124,-0.0014623718,-0.065970525,-0.05350886,-0.03660809,0.0116299,0.0059044748,0.037703604,-0.01744603,0.0421423,-0.005384608,0.06308777,-0.008751274,-0.018845238,0.044985026,-1.8471466e-08,0.08292627,-0.043021675,0.05670911,-0.06184994,-0.015188941,0.039504595,-0.025306076,-0.038199764,0.004423171,0.006382775,-0.0058249654,0.123125084,0.0060151084,0.042881403,0.050224345,-0.046503685,-0.013713805,0.026847411,-0.058826044,-0.010500771,-0.091354996,0.059747692,-0.11198665,0.06759691,0.029433785,-0.031032218,-0.018476278,-0.015279417,0.07425202,-0.051768404,0.0038055899,0.013435774,0.040096186,-0.0390921,-0.044886608,0.06716229,0.0075762533,0.045414254,-0.019907245,0.07422784,-0.004668839,-0.13123325,-0.030800862,0.016297093,-0.004281763,-0.00284282,0.080034256,-0.070702195,-0.043851048,0.011869868,0.052408937,-0.035846904,0.019998968,-0.08077876,-0.027356472,-0.007011993,-0.013989352,-0.08190126,0.01583161,-0.05021575,0.036800724,-0.029511075,0.085985675,-0.020711744 +1.1.1.345,"The enzymes, characterized from bacteria (Peptoclostridium difficile, Enterococcus faecalis and from lactic acid bacteria) prefer substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain. It also utilizes phenylpyruvate. The enzyme from the halophilic archaeon Haloferax mediterranei prefers substrates with a main chain of 3-4 carbons (pyruvate and 2-oxobutanoate). cf. EC 1.1.1.272, (D)-2-hydroxyacid dehydrogenase (NADP+). ",384,1.0,-0.00069056766,-0.053053,-0.08570018,-0.053742208,0.06395505,0.041221716,-0.1305687,0.0832113,0.06631389,-0.019893749,-0.014823027,-0.06887818,-0.04178436,0.08692988,-0.047102947,0.00054830004,-0.058983006,-0.024230955,0.064196765,-0.016694102,0.05682663,0.055221383,-0.014281388,0.0059400816,0.01714786,0.0012147422,0.06640165,-0.01593964,-0.01926158,-0.070663475,0.017514993,-0.033390556,0.06507526,-0.034627687,0.06972223,0.104701914,-0.010296858,-0.04863932,0.094375044,0.014646775,0.030308751,0.029919064,-0.016012166,-0.0010761116,0.021593494,-0.001193303,-0.023093084,0.07129725,0.040450126,-0.014565687,-0.04964012,-0.0330954,-0.055709194,0.04247786,0.0016341389,0.045362893,-0.025335325,-0.06721666,0.022445392,-0.06369639,0.027393188,-0.020583095,0.05230043,-0.0018592994,-0.020294843,-0.05478918,0.03855457,-0.10798164,0.007456802,-0.062285013,-0.15506971,-0.05541127,-0.0006335299,0.038678054,-0.0054933606,0.042388562,-0.028312119,-0.088081524,-0.000105638996,-0.09808412,0.04687626,0.038215864,0.0081520295,0.07204305,0.05083493,-0.010839039,0.04850737,-0.014002497,0.03921682,0.039911576,-0.0051734573,-0.008673194,0.0020039165,-0.03410723,-0.07872368,-0.011548965,0.04971452,0.017703557,0.027563054,-0.026737148,0.038208723,-0.0007248693,-0.026591962,-0.05565901,-0.0882975,-0.017287211,0.037392523,0.08678116,0.037206814,-0.053654894,0.007502412,0.016225733,0.013948878,-0.031148398,0.0008067494,0.07296694,0.05585619,-0.08764181,-0.064380765,0.05988013,-0.014438128,-0.038267005,0.10646269,0.016412197,-0.09404728,0.036573377,-0.12556009,3.8639634e-33,0.04567047,0.003998504,-0.01093344,-0.018997183,0.021160193,0.0063160425,-0.11747459,0.010522158,-0.050588857,-0.059578482,-0.07903471,-0.026977286,0.04082994,0.022828698,0.042990092,0.02599547,-0.021827951,0.039328832,-0.010751076,-0.0078008836,-0.029480668,0.0479966,0.013543231,0.00892834,0.13172509,0.008323695,-0.022480821,0.022922339,0.03604012,-0.01705374,0.050501816,-0.1334375,-0.0530461,0.027186029,0.089247674,0.06503183,-0.019486595,-0.03228022,-0.055037078,-0.021109153,-0.06474561,0.054574706,-0.02078315,-0.023136549,-0.012504374,-0.06615506,-0.0008478718,0.07059287,-0.008472993,0.0250587,0.032883327,-0.002465439,0.07245077,-0.09835762,-0.033207506,0.04332891,-0.039631397,0.008658136,0.0932305,0.03605079,0.036081657,0.06787269,-0.032622162,0.036517892,0.009479406,0.033114597,-0.062977694,-0.007037011,0.055395152,0.087056175,-0.083532594,0.0013823049,0.04267221,0.06059889,0.015133055,-0.05660404,-0.07648211,-0.023587918,0.04525418,-0.0149144605,-0.013822839,0.0046669263,0.024858037,-0.03415998,-0.026095675,0.06010591,-0.032399412,-0.025079403,0.0056091584,0.08379521,0.008321663,-0.06558721,0.0033734587,-0.00018540767,0.03352427,-4.78363e-33,0.0965584,-0.06885259,-0.014402394,-0.10989027,-0.0420852,0.108867705,0.009868109,-0.07708106,0.037621304,-0.03930995,0.08259766,0.04832419,0.052720964,-0.03328613,0.04216833,0.02656429,0.0065884143,0.021756684,-0.00638602,-0.01980236,0.05019146,0.057670753,-0.029007211,0.010724786,0.0057110004,0.05836392,-0.07384376,0.031103985,0.077549756,-0.0034118535,-0.057146654,0.09138738,-0.005454089,-0.08229711,-0.050014473,0.069946714,-0.120454326,-0.0039460137,-0.018109856,0.023963595,-0.029897692,0.042550478,-0.012111465,0.032213088,-0.0050018644,0.030775614,-0.02573448,-0.018134069,0.042614058,-0.04976097,0.0067760996,-0.025854504,-0.027350258,0.009673842,0.04898816,0.025334435,-0.0036328163,0.07340681,0.037507907,-0.06749135,-0.064667,-0.06162698,0.053848483,-0.03578598,0.019247415,0.0060492535,-0.045542337,-0.02681338,0.005220565,-0.034607925,0.036885202,0.021421893,0.016459445,0.037400603,-0.060597505,-0.02055098,-0.061892066,-0.016298516,-0.0031836051,0.0051973257,0.0031847907,0.008984257,0.02526254,-0.020575078,-0.012473655,-0.10303972,0.03613222,0.056103196,-0.019552965,0.049970943,3.2161788e-05,-0.0029258777,-0.03602397,-0.012744229,0.030822303,-4.6344066e-08,0.013456267,-0.06708666,0.073100954,-0.04255051,-0.05388094,0.006109737,0.0492827,0.0019462062,0.066240765,-0.10104984,0.037193727,0.08918096,0.04543094,0.012413826,0.021239681,0.035256326,-0.054870207,0.006864364,-0.006572905,-0.010099909,-0.11959877,-0.008118351,-0.07832518,0.05169771,0.05052009,-0.064568676,0.018507855,-0.005177899,-0.015651053,-0.030436508,0.011769205,0.08992748,0.0015062963,-0.08035247,-0.05042162,0.043875337,-0.06712587,-0.0070339646,-0.034778178,0.0780187,0.061433163,-0.05451466,-0.08218585,0.009748459,0.020845655,0.0427557,0.015315846,0.045512564,-0.058377948,-0.017343806,0.015725074,-0.046966475,0.015577693,-0.023155466,-0.048721112,0.037634563,0.050685946,-0.14678648,-0.03430347,-0.07024431,0.043342568,0.022833657,0.2323953,-0.037182976 +1.1.1.346,"The enzyme is involved in ketogluconate metabolism, and catalyses the reaction in vivo in the reverse direction to that shown [1]. It is used in the commercial microbial production of ascorbate. cf. EC 1.1.1.274, 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming).",384,1.0,-0.06688715,-0.007963347,-0.106225826,0.0174333,-0.060972925,0.01878019,-0.029630108,0.05816819,0.015588841,0.023350792,-0.0045562168,-0.011738848,-0.10803547,-0.016928801,-0.115189016,-0.00451468,0.06776553,0.0035088211,-0.023223434,-0.087333694,0.09982725,0.037098095,0.0382587,-0.014374567,0.09849398,-0.0040868553,-0.00864472,-0.03390955,-0.03782321,-0.11581188,0.030380135,-0.057398014,0.06247762,-0.037113577,0.05570704,0.103252195,-0.07821797,-0.052157387,0.074034475,0.03494867,0.021767417,-0.07637471,-0.023633977,0.016279483,-0.048939794,0.0039014437,-0.046999305,0.08525373,0.031449646,-0.027332606,-0.023363264,0.007991292,-0.033351056,-0.0069761067,0.020313047,0.0514436,-0.036361996,-0.011231231,-0.059458435,0.038681928,0.039933346,0.013229845,-0.037273876,-0.031355128,-0.0007795267,-0.09777225,0.025059102,-0.10224818,-0.011909923,-0.060566533,-0.011764708,-0.06885895,0.007750101,0.039593186,0.02312917,-0.015917892,-0.04103481,-0.014490489,0.032373477,-0.014501923,0.15790217,0.023302812,0.028000174,0.01864456,-0.005258849,-0.004143203,-0.045699704,0.03716575,0.081136376,0.043899234,0.017228594,-0.027481362,-0.04423875,-0.050706152,-0.104650296,-0.00054389576,0.07440705,0.07000813,0.09199658,-0.04756179,-0.011277431,0.012166167,0.004976278,-0.058080066,-0.088102065,-0.0476627,-0.04128404,0.0647576,0.07945025,-0.03377512,-0.017831078,0.04726279,-0.012429222,0.0012401588,0.034467116,0.1031007,0.07614846,-0.075408824,-0.085223906,-0.0146071445,0.011348723,-0.05401821,0.024127765,0.079449296,-0.066428,0.007926,-0.029439546,-1.47118885e-33,0.043117233,0.0138753,-0.015312116,0.00083756517,-0.025251308,0.012358807,-0.082233444,0.0017531792,-0.0075988127,-0.071088836,0.008283709,-0.050161667,0.04689465,0.08421753,-0.040136218,-0.011956388,-0.017557565,-0.01251593,0.04639507,-0.0038922825,0.06366371,0.051430903,-0.04574865,0.0904629,-0.048459526,0.038955033,-0.021511726,0.048672628,0.040334113,-0.014785361,0.016699882,-0.08136377,-0.11231924,-0.043300886,0.04759146,-0.00926068,-0.081037864,-0.0067194,-0.017908847,0.07964702,-0.011316004,0.019566637,-0.031860113,-0.044373598,0.016839458,0.03578898,-0.016786238,0.06326316,0.1059311,0.07116055,0.071444996,-0.02427905,0.09798169,0.021852849,-0.0029407134,0.1142169,-0.04466189,-0.06627621,0.039906297,0.032537993,0.017246408,0.028897015,-0.06117018,0.010383321,-0.056893464,0.00055928115,-0.028988045,-0.0110891145,0.019028027,0.07695899,-0.061250918,0.0006774885,-0.0066298516,0.0069403155,-0.04217297,0.004104622,-0.07631045,0.07847096,-0.005952989,-0.009125032,0.005144821,0.01943292,0.014459443,-0.0056225206,-0.046824805,0.040137436,-0.010421652,-0.092058174,-0.0067436276,0.026544783,-0.001670736,-0.06563516,-0.056433402,-0.025898136,0.07996949,-1.44142855e-33,0.14050844,-0.092261285,0.026716078,-0.0032897175,-0.012459707,0.055775102,0.10431781,-0.015719907,0.009931963,-0.0001705546,0.030151075,0.043761615,0.047450457,0.03696813,0.080950566,-0.06014744,-0.0332669,0.09121525,-0.045239292,0.027799917,-0.006835085,0.06548252,-0.0032831712,0.027716342,0.0396382,-0.025597814,-0.038798496,0.022396581,0.031842157,0.013316633,0.06032331,-0.001416381,-0.003966451,-0.047963664,0.013494473,0.09010851,-0.054246623,0.01642458,-0.066446334,-0.043646846,0.031326234,0.055619013,-0.019315027,0.009913814,0.014601362,0.07606682,-0.0766129,0.03217449,0.016914962,-0.08365128,0.069177955,0.035347916,-0.05149227,-0.046267267,0.0008465182,0.02762408,0.028524445,-0.035740867,0.0295922,0.000533832,-0.064984694,-0.09914901,0.06785266,-0.06530623,0.015117341,-0.009566001,0.038194787,-0.006951075,0.0033477582,0.036478147,0.07654244,0.024899727,0.014266239,0.07566336,-0.05097691,-0.061932035,-0.084439516,0.0055601387,-0.008884411,0.0039899647,0.009467072,-0.037446372,-0.0028240927,-0.011937181,-0.014502053,-0.11564201,0.050009772,0.09606762,-0.07088159,0.06743345,-0.0447118,-0.026390715,-0.038215198,0.05696931,0.09067517,-3.6145014e-08,0.026131788,-0.03609544,0.060176153,-0.048082486,0.018947916,0.059615403,0.07418751,-0.0054002465,0.029454695,-0.05510217,-0.046869084,0.095276125,0.03916912,0.06426289,-0.0057451227,0.0324676,-0.055047546,-0.03303796,0.005790691,-0.024859428,-0.011562247,-0.043465797,-0.11585201,-0.014686523,0.0072430773,-0.0503518,0.055947386,0.08699728,0.039042413,-0.08486727,0.03584824,0.03728233,0.053866502,0.008080914,-0.036453724,0.005537033,-0.09966192,0.015353738,0.019125106,0.020541165,-0.04834399,-0.013756852,0.013846188,0.038087856,-0.0969719,0.030344317,-0.024750814,0.005727193,-0.07429942,0.07694445,-0.017758677,-0.0029310682,-0.04792902,-0.007996306,-0.08691772,-0.0013387178,-0.026445225,-0.038841385,-0.05145267,-0.08801296,0.03988636,0.011699104,0.12228182,-0.028711908 +1.3.1.98,A flavoprotein (FAD). NADH can to a lesser extent replace NADPH.,384,1.0000001,-0.06341471,-0.04317589,-0.06545442,0.0039194645,0.04622997,0.049004477,0.007673989,0.072218366,0.048926387,-0.018877862,-0.0123313805,0.05998819,-0.06274394,0.027396,-0.04667845,0.015140568,-0.021545677,-0.01005135,-0.047866225,-0.007716757,-0.012664436,0.04571268,0.059081115,-0.031921584,0.058684547,-0.001974922,-0.025327146,0.0026932736,0.0064521963,-0.039506935,0.0029265508,0.09525469,-0.021539137,-0.008893368,-0.022367494,0.059217837,0.015212984,0.036201656,-0.0219072,-0.0021695066,0.050744094,-0.037325937,-0.04665177,0.0021247244,0.02261902,-0.014924907,-0.05308772,0.10233317,0.019370703,0.06980048,-0.049228296,-0.051221993,-0.0674435,0.050417714,0.05519723,0.011035773,0.012184998,-0.0056589046,-0.033464093,-0.041501306,-0.021199211,-0.0632575,0.013371592,0.028522713,0.045453906,-0.083514065,0.029662518,-0.016507063,0.025067026,-0.004028733,-0.03872273,0.026594207,-0.027043605,0.051855963,0.015473986,0.0890155,-0.08331076,-0.07417953,0.096132375,0.02936674,0.084054194,0.047091387,0.025250036,0.06030627,0.09875915,-0.0054970407,-0.008930078,-0.021137461,-0.0740026,0.023113273,-0.034603808,-0.035306793,0.028518144,0.027620858,-0.13279173,0.04228109,0.05545903,-0.06252063,-0.08932965,0.0056682485,-0.047411792,0.037596725,0.039681047,-0.028324094,-0.10875602,-0.016215904,-0.053114716,0.043489296,-0.054264173,-0.060681786,-0.013212197,-0.04937252,0.042607658,-0.10129812,-0.014036249,0.057681836,-0.021567674,-9.622109e-05,-0.08245801,-0.03970316,-0.06953449,0.063264616,0.045288708,0.06256888,0.03874873,-0.0011832512,-0.09571945,-2.9901692e-35,0.13521725,0.052421063,-0.01547061,0.028380232,0.04077464,0.029734982,-0.05777814,0.021136448,0.04453231,-0.067680486,0.0050924504,-0.04146897,0.02041672,-0.07792548,0.0757953,0.050530005,-0.03969371,-0.054697596,-0.01037257,-0.09541019,0.021238552,0.08496886,-0.019488676,0.041710574,0.015105338,-0.0428829,-0.05533346,0.05705533,-0.007210608,0.041056953,0.025190236,-0.030347819,-0.060801387,0.018483158,-0.04073721,0.004378822,-0.08611004,-0.11997687,-0.06715452,0.05270032,-0.0570324,0.014052179,-0.00904282,-0.0105163595,0.030357908,-0.12263713,-0.025493061,0.06462632,-0.042006325,0.05829368,0.031427193,-0.040200286,0.14199764,0.036296375,-0.07985554,0.017023472,-0.03885839,-0.03618645,-0.0073967907,0.053340677,0.06637913,0.028622808,-0.023555743,0.1125552,-0.10298217,-0.0075737415,-0.1019061,-0.090637095,-0.010834325,0.11071343,0.0655863,-3.2179538e-05,0.06710108,0.030801712,0.016912675,-0.05019695,0.005268736,-0.010319597,0.0048300656,0.015621321,-0.014043884,-0.06189557,-0.0690501,-0.013038233,-0.03554035,0.047284532,0.069294505,-0.06027841,-0.00077417516,-0.006381384,0.07292151,-0.037171684,0.004535095,-0.08719195,0.04127967,-2.861733e-34,0.0626456,-0.057504475,0.043646418,0.02937131,0.02022425,0.039156165,0.088138446,-0.059571564,0.02040375,-0.113920614,-0.0029037746,-0.025027327,0.0016718227,0.0006225439,0.034183107,0.016152818,-0.055672757,0.0009767249,0.032405473,0.05545305,-0.013412379,0.052281752,0.03405148,0.06962729,0.091736786,-0.059539158,-0.011725885,-0.013937043,-0.009855203,0.04631692,-0.004013243,0.030061245,-0.10740615,-0.02217001,0.0002936215,0.028957237,-0.00010438973,-0.050770365,-0.053057294,0.047157593,-0.018752081,-0.026067011,-0.00829113,0.041610077,0.110318564,0.05604226,-0.055707507,0.026435915,0.087851666,-0.06260576,0.038918305,0.050047915,-0.016993523,0.07907541,0.06424196,0.024163676,0.006928057,0.042008355,0.017679458,0.009630328,0.0008081126,-0.08892709,-0.03364777,0.0068198466,0.11535622,0.029760925,0.014093224,0.047470503,0.05324489,-0.04382948,0.11002511,0.0022302675,0.015627658,0.054285433,0.04518669,-0.066346794,-0.074802674,0.09028497,-0.058506608,-0.020053275,-0.041167103,-0.0021281277,-0.03131509,-0.012680359,-0.035884056,-0.037626553,0.032685734,0.007908,-0.014306612,0.010583939,-0.041359585,0.07097333,-0.024857853,-0.016189657,0.016503774,-2.2746152e-08,0.052392855,-0.044071507,-0.0063371914,-0.026025182,0.06911931,-0.0014221052,0.007438422,-0.022182364,0.0014303445,0.025359225,-0.032818694,0.17519855,0.06681507,0.019431038,0.057332832,-0.027901683,-0.0090261735,0.0030619109,-0.049376626,-0.04334931,-0.06433097,0.05188039,-0.057679348,0.056659453,-0.06365547,0.00024904235,0.011788493,-0.04790365,0.037716612,-0.06594498,0.04621113,-0.013995293,0.05988722,-0.03689986,-0.08412835,0.057218514,0.01342197,0.00878019,-0.02165173,0.09330613,-0.04978479,-0.049420845,-0.029092148,0.027572842,-0.0152902175,-0.06351286,0.08059871,-0.06470859,-0.05605289,-0.04556121,0.045592215,0.039967507,-0.01003418,-0.033564795,-0.04143824,-0.025516482,0.00057215366,-0.032014936,-0.029726926,-0.08623344,0.0391155,0.019351626,0.09888768,-0.018277496 +1.3.1.99,"Isolated from the plants Catharanthus roseus, Olea europaea (common olive), and several Nepeta species. The enzyme reduces 8-oxogeranial, generating an unstable product that is subsequently cyclized into several possible products, either non-enzymically or by dedicated cyclases. The products, known as iridoids, are involved in the biosynthesis of many indole alkaloids. cf. EC 1.3.1.123, 7-epi-iridoid synthase.",384,1.0,-0.029089203,0.034337524,-0.1161333,0.011881592,0.02364035,0.043504003,-0.05815813,0.024417788,0.090175815,-0.05149268,0.070968196,-0.077785835,-0.07460286,-0.07160595,-0.04653141,0.056948602,-0.04577944,0.096368186,-0.07377714,-0.06694637,0.071258895,0.033158764,0.00055708404,0.020898271,-0.010563246,-0.0049645933,-0.0082777105,-0.044760104,-0.036682315,-0.094009675,0.0137276435,-0.0037824605,0.012777753,-0.0041661705,0.034853112,0.06353252,-0.047481757,-0.027054101,0.03854315,0.061832834,0.010487789,-0.033033356,-0.029597998,-0.042494748,-0.013361043,-0.037537534,-0.02064934,0.039130647,0.036723793,-0.051141433,-0.056573655,-0.024034915,-0.0403156,0.019979062,-0.07606615,-0.07377834,0.0108018685,0.008143146,-0.024556318,0.067758374,0.08409217,0.020832125,0.014816582,0.028206894,-0.107668914,0.0049456665,0.020770565,-0.04186739,-0.009132753,-0.059831154,-0.010081185,-0.07423068,-0.036278874,0.00055061554,0.0014994453,0.10616655,0.033638813,-0.013359227,-0.04840724,-0.023307398,0.046863634,0.038659297,0.012767719,0.05062058,0.095721774,0.017236426,0.028824983,0.022505878,0.06423522,0.03512453,0.017262608,0.03213051,0.064817436,-0.032035064,-0.0036926898,0.094211094,0.04986869,-0.023405557,-0.0019077401,-0.006523835,-0.00978892,0.020537049,-0.04395046,-0.04908543,-0.11854213,0.019140396,-0.02696332,0.024983196,-0.03316873,-0.016306477,-0.01025939,-0.06460036,-0.037656933,0.007370719,-0.025124297,0.10263058,-0.0030449578,-0.04353474,-0.01709874,0.004898855,-0.022102136,0.0024250313,0.050120536,0.064841546,0.013996452,0.056374796,-0.10905847,2.8045198e-33,0.10098006,0.06771645,-0.06375545,-0.059931386,0.02022882,-0.016824493,-0.06940148,0.040646806,-0.05824262,-0.042434406,-0.083912194,0.030693058,0.026038364,-0.056767214,0.026347417,-0.012198428,0.044206366,0.0162492,0.065122925,-0.05105336,-0.027616857,-0.0069321324,-0.029642455,-0.003650152,-0.08202352,0.056991022,0.019760797,-0.03642418,0.02298406,-0.028411126,-0.028206982,-0.12859094,-0.024445023,0.016618116,-0.008502709,-0.0057013016,-0.076877855,0.009144214,0.00028251612,0.08853128,0.00080013374,0.1075568,0.066770494,-0.0036070764,0.10335348,-0.055471525,-0.069846235,0.091577455,0.0496109,0.029636104,-0.017001644,0.019807843,0.10829454,0.031360596,-0.07857471,-0.026741652,-0.02115096,0.032767422,0.025412718,0.021694927,-0.038674444,0.06282087,-0.0016642497,0.0035312336,-0.010660959,0.03250071,-0.04030619,-0.034991298,-0.05350638,0.027199466,-0.011636983,-0.051704828,0.06615947,-0.013183274,0.07038539,-0.03590159,-0.010709405,0.012376305,0.005227983,0.038304653,-0.023876697,0.02106517,-0.04458356,0.015465009,-0.00019206411,-0.022267807,-0.060077034,0.06042313,-0.011900912,0.06121232,0.053761918,-0.042884167,-0.062383562,0.017428974,0.02849366,-1.5563795e-33,0.03252844,-0.06863287,0.016946124,-0.11115477,0.007482146,0.07045894,-0.053032156,0.018584615,-0.01833867,0.031729806,0.00392654,-0.039754506,0.09414531,-0.034348432,-0.05370796,-0.08910869,0.060704928,0.14446294,0.029023819,9.879428e-06,-0.03019512,0.05548549,0.004882986,-0.01030147,0.06238357,-0.015009902,-0.011101053,0.06470955,-0.02680765,-0.014580726,0.02178006,-0.02609073,-0.083051406,0.0031224769,0.0055086515,0.09576879,-0.071080305,-0.03361063,0.057516407,0.07158319,-0.06377522,0.0027432495,-0.012207038,0.060830597,0.08955817,0.077973954,-0.052934866,0.067299016,-0.031714506,0.008948676,0.042640306,0.03236305,-0.022646038,-0.02444397,0.05361662,0.0018572721,0.024820073,0.04015139,-0.017708149,-0.037729867,0.034458056,-0.06538097,0.02570593,0.0063295444,-0.017339433,0.102176376,0.005237028,0.07966052,-0.023881659,0.02884357,0.12410602,0.014308181,-0.050795186,0.03589716,0.01974334,-0.054152284,0.010279908,-0.096970804,0.008362876,-0.08494527,-0.01042858,-0.005438998,0.035132203,-0.076978914,0.00010035594,-0.03154402,0.054701637,0.07691838,0.041943498,0.095089085,0.026489351,-0.009954352,-0.041379426,0.11798395,0.119482905,-3.7414548e-08,0.06351609,-0.07531587,0.05971272,0.0031288564,0.016273439,-0.023160346,0.020781476,0.014191778,-0.0069506695,-0.059977967,-0.008970819,0.038794458,0.022501364,0.041905694,0.07639087,0.0020169471,0.0843319,0.08059419,-0.0052428087,0.020548353,0.021540571,0.014164406,-0.033925727,-0.046620857,-0.010249744,-0.12353723,0.06147367,-0.06497527,-0.025667245,-0.067763194,0.05647811,0.013123414,0.02538956,-0.036407184,-0.026051603,-0.008436985,-0.02879471,-0.0024793008,-0.040163733,-0.073773764,-0.09644711,-0.062475797,-0.06411066,0.008564962,-0.0060518533,-0.011153786,0.012816278,-0.054076374,0.037282184,-0.011396747,-0.010745915,-0.05364939,0.10940358,-0.12010476,-0.08449468,-0.05043231,0.047276266,-0.056862805,0.039896183,-0.055763956,0.0121217165,0.010918656,0.16259131,0.027813187 +1.5.1.46,"The enzyme participates in the biosynthesis of ergotamine, an ergot alkaloid produced by some fungi of the Clavicipitaceae family. The reaction is catalysed in the opposite direction to that shown. The substrate for the enzyme is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione.",384,1.0,0.011328436,-0.0138818305,-0.11410537,-0.007183558,0.0572182,0.034474768,-0.017547924,0.047094073,0.034609713,-0.030347107,0.024381105,-0.10336558,-0.059801742,-0.03645766,-0.05181615,0.032933857,-0.06133357,0.004911542,-0.00850112,-0.03881083,0.029398505,0.033154357,0.04774155,0.031212494,0.025545804,-0.019264007,0.077011846,-0.04121002,0.018534051,-0.09835577,-0.020706398,-0.0949723,0.10351613,-0.04513774,-0.0039539477,0.077881515,-0.047632903,-0.030059122,0.04635567,-0.015374134,-0.021570992,0.033638094,-0.04480068,0.010711984,-0.05416462,0.0022818747,0.0012596309,0.075943425,-0.0050716554,0.022724638,0.039046343,-0.022840345,-0.06509228,0.024568608,0.04109717,-0.008988869,-0.08538101,-0.033588096,-0.05136731,0.054967646,0.09707949,0.053313695,-0.07224218,-0.039186172,-0.0053610033,-0.06366881,0.09204853,-0.053398196,0.005494451,-0.108473234,-0.035189837,-0.10473222,-0.0429368,0.016269162,0.04730335,0.025378566,0.0044387355,0.031086251,-0.017154008,0.0050946544,0.042500082,0.009120805,0.05871711,0.058985356,-0.0068937233,0.024020804,-0.0057636467,0.07132498,0.08219806,0.017876172,0.08513862,-0.034493826,-0.04347675,-0.038087904,-0.030703846,0.10306093,-0.007816058,0.049505915,0.058502704,0.0113857705,0.041023474,0.02221393,-0.055546716,-0.054983106,-0.02835627,0.016969597,-0.008713315,0.031096034,-0.003318785,-0.06003417,0.023894602,-0.014963889,0.02979275,0.012137829,-0.05978591,0.088446416,0.09192339,-0.054205317,-0.11050916,0.050786246,0.012265333,0.038548913,-0.00033248222,0.0877444,-0.0031368048,-0.049614474,-0.04044129,2.382576e-33,0.08006186,0.008778979,-0.053104255,-0.04360523,0.0024642404,0.060336087,-0.08680931,-0.008060594,-0.07382569,-0.047965314,-0.057000797,-0.059380975,0.022633245,0.0102545265,-0.0021142121,0.029160608,-0.02454685,-0.027477894,0.095397525,-0.012340684,-0.043592382,0.013641128,-0.071829356,-0.0053205686,-0.049705163,0.15481639,-0.009163196,0.035150785,-0.0006528794,-0.018370308,0.039779574,-0.11500345,-0.087168925,0.06878494,0.02276567,-0.007860965,-0.031830527,0.0054427534,0.010117238,0.009647678,0.007239063,0.07773183,-0.05550357,-0.009058554,0.042962078,-0.09754819,9.586753e-05,0.09314581,0.09440862,0.07612406,-0.018709734,-0.047271866,0.09834477,-0.007879627,-0.071746826,0.046581898,-0.0019269225,-0.008771908,0.048967954,0.051258564,0.009512134,0.04182437,-0.010854913,0.050543696,0.053569384,-0.0034059344,-0.0300154,-0.06496367,0.014808303,0.028952584,-0.028377488,-0.090168245,-0.011830226,0.065646045,-0.061580833,-0.027924407,-0.08930234,0.017378096,-0.037845593,-0.009708649,-0.006308448,0.019096904,0.00431237,0.0036807256,-0.046257865,-0.008418881,-0.07484008,-0.054456398,-0.03246048,0.05793342,-0.01840911,-0.01050925,-0.04075481,0.03258355,0.05694482,-3.759963e-33,0.15135302,-0.122069314,-0.005127608,-0.08328811,0.008355192,0.038583506,0.004805577,0.024891159,-0.045787543,0.075831205,0.01798178,-0.018439984,-0.0015251238,0.011164766,-0.004272403,-0.004604375,0.059798975,0.12192508,-0.010922949,-0.026900964,-0.04100532,0.059118528,0.0028342123,0.04758886,0.02740231,0.02627431,0.03283634,0.002160564,-0.015546886,0.037799615,-0.040691108,-0.031377345,-0.0033656785,-0.04461731,-0.014858814,0.07857224,0.018970676,0.007258226,-0.037337195,0.026936837,0.029265178,0.09271042,0.037759338,-0.005737767,0.074681945,0.068301685,-0.040932037,0.055900294,-0.05811424,-0.08376994,0.047117267,0.03947534,0.058068845,0.01339622,0.005680226,0.04250829,0.010980783,-0.038076412,0.016106913,-0.0053129345,-0.051163986,-0.04213493,-0.03332765,-0.03954094,0.031130202,0.029846136,-0.019334963,0.050872695,0.029540628,-0.030711405,0.07903093,-0.04754455,-0.02225379,0.05161565,-0.109588705,-0.031339888,0.02182612,-0.08586135,0.05825625,-0.045433298,0.05412672,0.010652108,0.047803063,-0.033328682,-0.055245206,-0.11505852,-0.0013813607,0.10886027,-0.013447904,0.051829718,0.06010328,-0.0143325,-0.05796771,0.09884541,0.13230932,-3.972815e-08,0.034496535,-0.08226305,-0.01681439,-0.024293177,-0.044001006,0.010496277,0.06259667,0.003921685,-0.022369854,-0.018868087,-0.020787597,0.040669385,0.00045474514,0.041475493,0.07271233,0.041190796,0.0068387957,0.06706539,-0.059905425,0.025428746,0.0006089465,-0.033892974,-0.057063114,-0.019953107,-0.0024528273,-0.078841366,-0.042575203,0.022007,0.028408745,0.022835722,0.044745635,0.036021728,0.0026520393,-0.07652007,-0.074277915,0.002783234,-0.024448251,-0.087536745,0.0016269817,-0.043672264,-0.008822931,0.014259511,-0.033620868,-0.015621644,-0.037509717,-0.016979951,-0.02193985,-0.021868436,0.037411597,0.008646474,0.07025836,-0.06579637,0.034179695,-0.06393532,-0.13514628,-0.041251432,-0.014962552,-0.07526131,0.009030256,-0.07620951,0.047404535,0.025380552,0.17115285,-0.022635676 +1.7.3.6,"The enzyme from the heterotrophic nitrifying bacterium Paracoccus denitrificans contains three to five non-heme, non-iron-sulfur iron atoms and interacts with cytochrome c556 and pseudoazurin [2,3]. Under anaerobic conditions in vitro only nitrous oxide is formed [3]. Presumably nitroxyl is released and combines with a second nitroxyl to give nitrous oxide and water. When oxygen is present, nitrite is formed.",384,1.0,-0.08263011,-0.06792668,-0.11987229,0.011101187,-0.0014030942,-0.04662019,0.011385445,0.025903942,-0.027719432,-0.002928254,-0.015184982,-0.05576534,-0.020528678,0.05933944,-0.09647794,-0.022568736,-0.06555293,-0.06640175,0.0064402046,-0.018378196,0.07433729,0.050841328,-0.09351969,-0.044303652,0.008684202,0.013380292,0.03629149,-0.018553644,-0.02245214,-0.0106659,-0.052834094,-0.015762834,0.014147158,-0.06887844,0.13763753,0.036704857,-0.017553976,-0.0063818158,0.07606818,-0.024758747,0.018327497,0.010033702,-0.033188995,0.05152795,0.05593717,-0.0005149963,0.030474544,0.07321909,0.048753843,-0.07534942,-0.028424192,-0.028094523,-0.01602386,0.08698953,0.036692094,-0.0390501,-0.06964448,-0.066900946,0.037000336,-0.028656265,0.039630078,0.003052217,-0.0068368027,-0.0259491,0.042621907,-0.01245538,0.07523585,-0.029850824,0.0049220496,-0.022166058,-0.056882493,-0.0024160598,0.053080782,-0.022492377,-0.053857923,0.011042309,0.08388476,-0.08657141,0.021171771,-0.08314654,0.053236183,0.04594705,0.033861417,0.09046784,-0.017538493,-0.00011650589,0.032562215,-0.06712291,-0.008266349,0.048953485,-0.030899486,0.055405624,-0.013368973,-0.096498206,-0.06459716,0.03721365,-0.046526965,0.10790259,0.0026566205,-0.0039573866,0.005223163,0.052762818,0.015931806,-0.07773796,-0.02058493,-0.0026757184,0.04198734,0.093760334,0.13511448,0.11016266,-0.028422099,0.023947345,-0.043718304,-0.030146498,-0.029920038,0.0814407,0.0968258,-0.024341041,-0.11078172,-0.0036513878,0.007465252,-0.040296827,-0.023234844,-0.05443331,-0.038047202,0.016656656,-0.03922946,5.2001277e-33,0.08616661,-0.008069071,-0.008945766,0.025942435,-0.026244981,-0.012271231,-0.1255196,0.010264162,0.03454732,-0.013193977,-0.07986061,-0.08465936,0.0065303002,0.0067238817,-0.04101813,0.0058093355,-0.016222404,0.031422537,-0.008093474,0.061437532,0.02809816,0.09226927,-0.06813042,-0.04398996,0.041510392,0.0138811,-0.03186607,-0.04205198,0.026466679,-0.042994402,0.077438384,-0.090548836,-0.06353273,1.9064986e-05,0.13327505,-0.0034460803,0.031816315,0.03330713,-0.020998275,0.02830929,0.025788581,0.079579495,0.0017245745,0.004920549,0.0037831878,-0.08364116,-0.05466115,0.079224415,0.024210714,0.043176547,0.02606055,-3.2024196e-05,0.07939117,-0.04409539,-0.0005647511,0.026669439,0.01968578,0.007990562,0.12723152,0.0019312882,0.06277614,-0.001164706,-0.033797085,0.037597064,0.10277977,0.03320013,-0.05083803,0.045715913,0.10151929,0.044440363,-0.16937783,0.056134444,0.0154704135,0.0176597,-0.0073662084,-0.05956276,-0.036821578,-0.015127901,0.054492302,-0.022127897,0.062202282,-0.080007106,0.023758471,-0.03638489,-0.00878944,0.034333307,-0.04181285,0.027162291,0.003040256,-0.056667857,0.045583047,-0.043073542,-0.090718396,-0.12107801,0.0047429316,-5.327049e-33,0.09476871,-0.040063582,-0.01953432,-0.071158215,-0.030601846,0.061774675,-0.05271361,-0.000744713,-0.037860256,0.009867452,0.11391116,0.0024563975,0.05716153,-0.0021579696,-0.01981558,-0.0131894145,-0.042004332,0.020122048,-0.05073249,-0.049347013,-0.026373358,0.026640581,0.010022326,-0.075527705,0.019190468,0.04477248,-0.044685647,0.08986027,0.05503079,0.04527366,0.023955813,0.028980555,-0.07459647,-0.08255413,0.020562338,0.02950061,-0.02856413,0.010810401,0.0044663046,-0.05763264,0.03238348,0.028855009,0.020335304,0.14591905,-0.021113323,0.01775102,-0.09416611,-0.061242037,0.03195802,0.028511278,0.073244445,-0.033742186,-0.08725037,0.018755265,0.06073139,0.003402393,0.017307388,0.05369154,-0.02983233,0.008064735,-0.06631348,-0.037261065,0.017664405,-0.027894897,0.025359163,0.000404272,-0.020993873,0.07707293,0.027137227,-0.031116698,-0.00521968,0.08197877,0.019059176,-0.062269285,-0.098728046,-0.036689546,0.043334667,-0.017735954,0.018305168,0.0024231954,0.023947272,0.010316008,-0.047910318,-0.027961198,0.02819863,-0.009718473,0.021924034,0.030532572,-0.0674489,-0.0045161005,-0.018683188,-0.014466934,0.024947759,0.014531883,-0.0904313,-3.9425426e-08,0.02194037,0.0152214365,0.054067124,0.017977208,0.020973016,0.066139646,-0.01840391,-0.06122152,0.024452113,-0.0020177972,0.04643759,0.04431541,-0.02202654,-0.046568956,0.042009074,-0.004059227,-0.039571263,-0.010674781,-0.034192625,0.020100828,-0.027927378,-0.0404775,-0.12314617,0.1003622,0.08595514,-0.043099616,0.07682342,-0.06388063,-0.0024088633,-0.010414375,-0.008832548,0.057101328,-0.013144976,-0.041713852,-0.058524046,-0.038377058,-0.0072613913,0.048530653,-0.07065352,-0.05525913,-0.0067428267,-0.027365804,-0.11265734,-0.01157131,-0.029678058,-0.02220006,-0.02957804,0.028446525,-0.043834474,0.03248059,0.043405477,-0.045872625,0.041249894,0.0039900783,-0.07574364,0.0739383,0.07477176,0.0091468105,-0.007520445,0.05580466,0.0036248025,-0.01004158,0.10683755,0.05568156 +1.11.1.22,"The enzyme, characterized from the cyanobacterium Synechocystis PCC 6803, can reduce unsaturated fatty acid hydroperoxides and alkyl hydroperoxides. The enzyme, which utilizes NADPH generated by the photosynthetic electron transfer system, protects the cells from lipid peroxidation.",384,1.0,-0.13235852,0.035433955,-0.07037731,0.03586484,0.041360345,0.050827377,-0.103130125,0.068710715,0.005880498,0.00516724,-0.023944242,-0.0037467487,-0.06704944,-0.026244845,-0.052694578,0.105953045,-0.024341112,0.07462199,-0.017778339,0.03501314,0.028831324,-0.00730286,-0.018257318,0.0019737745,0.016692048,0.022300329,0.0032939045,0.039018203,-0.037985697,0.010481266,0.0027992865,-0.07180788,0.029054489,-0.032551985,0.05048184,0.079791896,-0.03928287,-0.09470021,-0.037035465,0.014508774,0.034432847,-0.0004685146,-0.07954943,0.04226016,-0.008707986,0.013537617,0.04635322,0.004835301,0.005679085,-0.1111617,-0.03162562,-0.038851406,-0.07296038,0.0088226525,-0.0060977684,-0.0022207967,-0.06613116,-0.047763877,-0.009179676,-0.0009989016,0.029114101,-0.038859136,0.00655213,0.05872499,0.06566283,-0.09037222,-0.026599828,-0.021054026,0.008323387,-0.045656726,-0.059284,-0.042821705,0.045880318,-0.005438538,-0.070100985,0.05741457,-0.032040432,-0.105309084,0.024479054,-0.020548442,0.06491354,-0.0379021,-0.07533104,0.153576,0.08071775,-0.0062302975,0.028314898,-0.039207697,-0.064814486,0.01412403,0.050623562,-0.0014228402,0.008105221,-0.05741258,-0.13547072,0.026032882,0.103031956,-0.004451045,-0.010226887,0.017725347,-0.0010109366,0.086840495,0.004941646,-0.15472063,0.020397803,0.0318242,0.011442632,0.09748888,0.006869094,0.022678068,-0.028337866,0.01648322,-0.08191684,0.02539623,0.015378332,0.03901075,0.040520824,-0.035242233,-0.07670115,0.037824363,-0.033419885,-0.08368886,0.021956017,0.00048343622,0.012620061,0.019453382,-0.06040976,4.5908796e-33,0.06493516,-0.033840097,-0.047395054,-0.08160511,0.06496509,0.00018865817,-0.07067679,-0.05255194,-0.00065837207,-0.016977884,-0.07092975,-0.08109495,0.046571232,0.0038451357,-0.034834143,-0.01126793,-0.07950652,0.034145616,0.064841956,0.052745588,0.05098209,-0.011288577,0.0014533137,0.012458481,-0.00383324,0.024001747,-0.051932447,-0.026801437,0.050099716,-0.02224591,0.014034476,-0.028070929,-0.096273445,-0.021286825,0.10660491,-0.007670428,-0.034175497,-0.091584146,0.0072020493,0.0038664872,-0.102760345,0.03307432,-0.008320135,-0.038787715,0.05271557,-0.005679257,-0.04270444,0.09020767,0.05398725,-0.012886296,0.06764498,-0.04367191,0.05849563,-0.0013047665,-0.0008715307,-0.05540617,-0.019613247,0.028144943,0.0075500095,0.051062897,0.002520043,0.028168421,-0.044287346,0.05085373,0.040279206,-0.012404842,-0.09626033,-0.010706271,-0.01148553,0.02415204,-0.0046120575,-0.010930555,0.062856086,0.034710485,0.0077190693,-0.015409908,-0.0009957562,0.04117172,-0.012330801,0.0056362385,0.021103738,-0.020259958,-0.01672182,-0.038081817,0.004132072,0.05655103,-0.03884079,-0.0012695151,-0.006286274,-0.0039346307,0.08904861,-0.0622548,-0.04951485,-0.029153354,-0.06727006,-4.8049573e-33,0.055744663,-0.074240774,0.035890605,-0.058818422,0.018803006,0.106212765,-0.026350025,-0.026422977,0.046578187,-0.044505395,0.12710796,0.002022317,0.06800806,-0.0035960858,0.010172124,0.013101061,-0.038644988,0.037338044,-0.058936205,-0.04844013,0.0006097263,0.06529252,0.05089775,0.08131903,0.03795921,-0.030011527,-0.11239808,0.054061342,0.08527601,0.018744744,-0.029226162,0.029112887,-0.06870117,-0.017850967,0.05129857,0.03130989,-0.086635426,0.00023874338,0.024552595,0.093496576,0.11472116,-0.082380466,-0.04399406,0.05127593,0.06636738,-0.004508032,-0.11096198,0.012627195,0.045890994,-0.00916223,0.05335367,-0.0052224575,-0.023612246,0.083718285,0.12852253,0.05968475,0.07928125,-0.037375927,0.054537162,-0.023909543,-0.040262736,-0.09867046,0.029589057,0.028168226,0.028491946,0.10084132,0.059162565,0.11675442,-0.013537544,-0.012678244,0.08064211,0.018260473,0.038775403,0.0053236755,0.012870334,-0.04018527,-0.04413445,-0.004805199,-0.060779735,-0.017175911,0.010982046,0.011360948,0.020312194,-0.09617845,0.021499466,0.027783258,0.004950235,0.026632512,-0.08362686,-0.018559627,0.010533734,0.026636694,-0.0049878736,0.049819563,0.019790787,-3.6535088e-08,0.01772911,-0.039928667,0.07364714,-0.036691915,0.00094062916,-0.013784433,0.04691987,0.027813228,0.03603312,-0.03107069,0.08730086,0.12916182,0.0520625,-0.0466394,0.062905274,-0.004917281,0.013179713,-0.010963095,0.0057801446,-0.024571618,-0.06486504,-0.06826667,-0.081650525,0.059135366,0.004163848,-0.04207508,0.049360488,0.060849536,0.0087202955,-0.032158718,0.038114727,-0.016709968,0.012500821,0.012344942,-0.0050223186,0.063089676,-0.008309203,-0.04211049,-0.07326565,0.08103767,-0.09372928,-0.024787044,-0.08311081,0.015106106,0.008220175,0.009431361,0.01825392,0.04005307,-0.038373265,0.027370626,0.019561253,-0.00044691665,-0.0115863625,-0.047650028,-0.07844129,-0.0113138305,0.020099746,0.003826696,-0.07599699,-0.012725994,-0.003210503,-0.011751712,0.1564259,0.008549905 +1.12.1.5,"A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+).",384,1.0,-0.061742667,-0.016562786,-0.09092552,-0.024602871,0.07285016,0.013936372,-0.04809603,0.013772526,0.03226716,-0.08818571,0.016620712,-0.023048803,-0.11768435,0.0271179,-0.01748262,-0.05441493,-0.0952678,-0.013166663,0.030721271,-0.048882797,0.040492017,0.016078105,-0.018390391,-0.0309021,-0.03604768,0.08624977,0.039077364,0.003462409,-0.06466485,-0.039910838,-0.028200189,-0.10515596,0.04622937,-0.06836982,0.039576415,0.071293175,-0.011097388,-0.06578079,-0.015697379,-0.020453682,0.045053165,0.028424,0.0020708903,-0.020969968,-0.03602993,0.043299593,0.08633071,0.061153706,0.029285422,-0.016203998,-0.042393252,-0.035586044,-0.039615326,0.07435361,-0.0034935388,0.037860908,-0.0051398096,-0.06831558,-0.021789163,-0.082230285,0.047971237,-0.003529389,-0.0038095396,0.0028439998,0.03453127,-0.012155293,0.05929446,-0.07193302,-0.021456277,-0.06453287,-0.061205804,-0.009926772,-0.074014515,0.05675998,-0.040599838,0.097680315,0.0070940317,-0.068238884,0.06713977,-0.028213823,0.011921731,0.03743877,0.014082799,0.056060556,0.028623266,-0.021424357,0.0557096,0.013639734,0.00650466,-0.019999279,0.019563528,-0.049402684,-0.013575104,-0.05232029,-0.069405705,0.05746598,-0.018293448,0.1362337,0.012690095,-0.022907237,0.02449059,0.020104647,0.018436247,-0.0987917,-0.07458321,0.02454365,-0.06336278,0.16868617,0.057965048,0.041602377,-0.036172718,-0.04022904,-0.007547469,-0.0023841718,0.02637794,0.047138307,0.09570551,-0.07012143,-0.1100513,0.06232752,0.05948066,0.019164009,0.06184913,0.08512171,-0.0054449798,0.0025839678,-0.18366282,1.9132802e-33,0.025483124,0.041138116,0.043517545,-0.077693306,0.003437405,-0.002504846,-0.110023156,0.017181383,-0.045793887,0.034758113,-0.07568909,-0.0007556707,0.061164375,-0.0651661,-0.06053651,0.026281679,-0.022005552,0.03807382,0.06127735,0.011327704,0.011082212,0.12895104,-0.0062648864,0.0010568489,0.06451691,0.052826747,-0.0033099882,-0.017233089,-0.035647914,-0.017293347,0.06756053,-0.1406387,-0.09307984,0.0025526294,0.120069325,-0.061195888,0.05549474,-0.07750719,-0.037604522,-0.056203365,-0.0052332017,-0.013627915,0.0091311075,0.01298442,0.04218238,-0.081953086,-0.03848187,0.07105547,-0.00903764,0.008708747,-0.0040785912,-0.0010566397,0.10228184,-0.047917217,-0.09229052,0.017507466,-0.0043379455,0.022604093,0.048728663,0.04640103,0.050882686,0.11195592,-0.023808071,0.044719245,-0.019210344,-0.0012877169,-0.016474765,0.022525147,0.076731205,0.08701512,-0.040354524,-0.005960099,0.035118926,0.019052763,-0.019640002,-0.040119857,-0.024671929,-0.04847177,0.009956234,0.045740325,-0.076776095,-0.054574598,-0.0025507633,0.009643435,-0.07414856,-0.012023057,-0.029809423,0.0024257728,0.000783364,-0.0016320265,0.0047893557,0.016838463,-0.05505923,0.00547805,-0.0013917922,-3.5261635e-33,0.057945915,-0.108238585,0.027974388,-0.13652974,-0.059899814,0.091203496,0.063304834,-0.005640793,-0.0069099064,0.010337886,0.07761001,-0.012330083,0.007758726,-0.08747536,0.05749533,0.049249504,-0.013764658,0.038392384,0.052418422,0.033813864,-0.017386332,0.0771299,-0.040246285,0.039886866,-0.026523124,0.012182965,0.026526526,0.0493309,0.06255723,0.004960733,-0.014235038,0.019491324,0.003805175,-0.110142075,-0.048336513,-0.0098921405,-0.028456071,-0.009078277,0.06514344,-0.013581227,0.053293,0.016145457,0.012929547,0.07034354,0.025997322,0.027043227,-0.074020855,0.041208312,-0.0573135,-0.008767125,0.0519173,-0.015819732,0.009600602,0.032388624,0.024809418,-0.009883106,-0.022991076,0.05100433,-0.037673548,0.07713315,-0.033049002,-0.08990864,0.04264157,0.07945851,0.015138703,-0.030861259,-0.052022196,-0.04631829,0.009301901,0.032018177,0.040139984,0.04948688,0.01450771,0.0158311,-0.023361279,-0.025576305,0.029821983,0.04768495,0.033468064,-0.008900157,0.014352283,-0.012390396,0.0028067427,-0.06365614,0.06532397,-0.058934376,0.021852612,0.14248492,0.008694321,-0.054002557,-0.00038265155,-0.022361493,-0.057827257,0.029741207,-0.018927658,-4.038695e-08,0.011076612,0.011765131,0.061637197,-0.03025054,-0.0059753964,0.020860057,0.07145765,-0.058084995,0.016008705,0.029415583,0.072151914,0.045690835,0.0032825058,-0.05730831,0.020545367,0.02066336,-0.025207568,0.020116774,0.01918863,0.053167943,0.0004912136,-0.0142183285,-0.09912448,0.013911349,0.02778925,-0.07220173,0.018277887,-0.047546405,-0.052080706,-0.03011893,-0.006144148,0.031578686,-0.00753412,-0.030854503,-0.025156364,0.0113574965,-0.033289474,-0.009245983,-0.020670945,-0.036516905,-0.0229272,-0.0072652153,-0.053442925,-0.02046428,0.0009727812,0.03131732,0.0021850637,0.010452582,-0.024265185,0.020839868,0.059320647,0.034217484,-0.011398396,-0.09691071,-0.08704872,0.04771454,0.057586785,-0.13035,-0.0615398,0.0026462092,0.13007233,-0.05457888,0.10731405,-0.004854678 +1.12.98.4,"An iron-sulfur protein. The enzyme from the hyperthermophilic archaeon Pyrococcus furiosus is part of two heterotetrameric complexes where the beta and gamma subunits function as sulfur reductase and the alpha and delta subunits function as hydrogenases (EC 1.12.1.3, hydrogen dehydrogenase [NADP+] and EC 1.12.1.4, hydrogen dehydrogenase [NAD(P)+], respectively). Sulfur can also be used as substrate, but since it is insoluble in aqueous solution and polysulfide is generated abiotically by the reaction of hydrogen sulfide and sulfur, polysulfide is believed to be the true substrate [2].",384,0.99999994,-0.04091238,-0.042855576,-0.07660274,-0.006411565,0.0574677,0.029361932,-0.03732807,0.016597815,0.0024512224,-0.05252937,0.014454537,-0.00035118795,-0.07977173,0.028882915,-0.049241394,-0.0144878905,-0.0317416,0.020314503,0.07582219,-0.0014960242,0.093369804,-0.07133158,-0.0046812007,-0.03574618,-0.039256103,0.08182333,0.056851704,0.019802105,-0.06413464,-0.02373654,-0.04474493,-0.09910119,0.006956026,-0.052320883,0.005622835,0.109123304,-0.026235938,-0.06212589,0.026219098,-0.055359222,0.058016445,-0.03655553,-0.014560764,-0.0070787286,-0.04970755,-0.0038254587,0.06096846,0.016385507,0.017116632,-0.008691886,-0.06746991,-0.0031094044,-0.010563705,0.023464648,-0.02465169,0.053034183,-0.01926218,-0.0095289415,-0.027692443,-0.087190956,0.057602003,-0.012978725,-0.024980024,-0.036589026,0.020798933,-0.0043728687,0.050858248,0.0025808152,0.009853212,-0.026963925,-0.11398893,0.08462442,-0.060249772,0.029562544,-0.006982834,0.13777217,-0.031643916,-0.08044266,0.04574017,-0.033876922,0.030896131,0.020445867,0.006498796,0.08643738,0.042749062,-0.030801643,0.048633885,0.00633211,-0.024845649,-0.018073305,0.017320774,-0.01731362,-0.016242994,-0.015334916,-0.05602835,0.033225257,0.0018211791,0.12869495,0.043673176,-0.057157855,-0.021346383,0.0004109764,-0.028619435,-0.08995292,-0.011991742,-0.0112941135,-0.07358276,0.15072927,0.10250016,0.02016709,-0.079539776,-0.005163679,-0.008400467,0.0056458293,-0.0014041591,0.11717261,0.12761387,-0.041207034,-0.14504877,0.035762817,0.035968494,0.04581183,0.05567206,0.027792234,-0.028354272,-0.07488975,-0.14554185,3.191272e-33,0.043857507,0.059968572,0.054762337,-0.016249117,-0.012383811,-0.014915595,-0.09442389,-0.034001634,-0.036893427,0.017702457,-0.08513625,-0.055924807,0.043248728,-0.015339378,-0.009659358,0.020882962,0.011013421,0.044873476,0.080029525,0.018362973,-0.007377492,0.09388604,0.019343851,-0.053379204,0.03243238,0.026360499,0.044629335,-0.0068904096,-0.03481618,-0.0038656539,0.07189334,-0.14588647,-0.07708586,0.047523007,0.14089803,-0.01676635,-0.026208906,-0.050340537,-0.024010876,-0.06201796,-0.03088402,-0.027033804,0.041201577,-0.012837328,0.039226077,-0.09148396,-0.017263431,0.05995678,-0.013830118,0.033741947,0.0068280464,0.0004658146,0.09924138,-0.022003096,-0.05452344,-0.016183967,0.0023658886,0.008457934,0.005543755,0.0808559,0.06618029,0.09386718,-0.041971557,0.055425607,-0.07539497,0.008721547,-0.025393225,0.03766626,0.04047362,0.09625763,0.00075871614,0.0020088293,-0.017088298,0.028825518,-0.044729643,-0.003846725,-0.03748033,-0.03273614,0.058687154,0.019719029,-0.012163953,-0.032592334,0.021792587,0.014979388,-0.1034759,0.012734138,-0.035038356,0.016262457,0.016945923,0.048939873,-0.0010449098,-0.041239046,-0.05401515,-0.00070048415,-0.022830276,-4.663928e-33,0.09970505,-0.071417116,0.023605581,-0.145733,-0.10019709,0.08892468,0.06920608,-0.009206155,-0.017832894,0.022543667,0.09642704,0.0074297884,-0.01026369,-0.07295367,0.0066218385,0.06570407,-0.010323549,0.0035790731,0.048739064,-0.047589388,0.00015447332,0.09741542,-0.008533779,0.049692005,-0.010352506,-0.038494874,0.06297548,0.07685985,0.03692553,0.068305105,0.0026536165,-0.021950541,-0.0031205514,-0.07764152,-0.012415788,-0.00730097,-0.006668564,-0.01095964,0.045833748,0.007485425,0.044545878,-0.029051637,0.0036752303,0.025839819,0.033981748,0.03847336,-0.07393586,0.00094631535,-0.003668976,-0.01660185,0.04363676,-0.057586934,0.020691907,0.030121665,0.048261825,0.012205297,-0.06276789,0.0409269,-0.06341964,0.016728245,-0.023118328,-0.08894199,0.018410677,0.034284703,-0.0060819034,0.020854414,-0.048087273,-0.030004667,-0.023467837,0.02619615,0.06957205,0.04720275,-0.038410526,0.0199966,-0.015792778,-0.034912214,0.006197764,0.074901395,0.011466908,0.002078367,0.04311208,-0.009130015,0.033793285,-0.07726416,0.07855052,-0.0636124,0.05557657,0.08762458,-0.0562988,-0.04587591,0.0336284,-0.013983685,-0.053975,0.04473041,-0.006584041,-4.397538e-08,-0.022492303,0.026541067,0.04007766,-0.05591909,-0.07065925,0.025603635,0.052930336,-0.05264298,-0.0033258072,0.012022548,-0.013591247,0.05117935,0.037151277,-0.036132023,0.0047860527,-0.016356135,-0.02748788,0.024717527,0.0053927363,-0.022459228,-0.042093012,-0.018815512,-0.11247876,0.03612182,0.051290948,-0.04796517,0.058233637,-0.09561352,-0.021582104,-0.025973698,0.023986617,0.0037421088,-0.039510522,-0.054952815,-0.026870321,0.016676154,-0.07254384,-0.0010432401,0.0045717116,-0.012618639,0.0016179284,0.038590077,-0.022147506,0.024206901,0.08169491,0.059518844,-0.029399592,0.031742517,-0.04360554,0.02904609,0.109333165,0.028687987,0.014506532,-0.099523515,-0.103639364,0.0573832,0.02811757,-0.08034242,-0.06127317,-0.003136499,0.12090796,-0.03090575,0.103465915,-0.013436252 +1.13.12.20,Involved in the synthesis of aflatoxins in the fungus Aspergillus 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+1.14.15.12,"A heme-thiolate protein (P-450). The enzyme catalyses an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl-[acyl-carrier protein], an intermediate in the biosynthesis of biotin. The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal. The mechanism is similar to EC 1.14.15.6, cholesterol monooxygenase (side-chain-cleaving), followed by a hydroxylation step, which may occur spontaneously [2].",384,1.0,-0.12945345,-0.011559135,-0.07598179,0.0043608802,-0.0048688753,0.0466225,-0.11555276,0.07726653,0.019115705,-0.0666673,0.04655544,-0.06602811,-0.02881635,0.0070330524,-0.04245862,0.01905546,-0.10646124,-0.00079138885,0.015945334,-0.08086062,0.04375678,0.04480982,-0.040832546,-0.0061924784,-0.06444414,-0.049300205,0.09350428,-0.08694612,-0.04696635,-0.056142278,0.007087688,-0.03575522,0.0464647,-0.030591175,0.01289152,0.0743767,-0.00018581073,-0.0410251,0.1344992,-0.014767128,0.05916796,-0.04846576,-0.047049373,-0.012573681,0.0119121075,-0.052593205,0.005268291,0.021605534,0.018237757,0.0046675242,-0.08147939,0.004889961,-0.030540487,-0.011534745,0.041397754,-0.022962399,-0.010781498,-0.06286624,0.012663605,-0.005007582,0.019074805,-0.001769462,-0.03677252,-0.0054839933,-0.06680447,-0.15105678,0.050660543,-0.042702567,0.012093348,-0.011222503,-0.046592485,-0.06355437,-0.051841184,0.048122924,0.010532744,0.06763133,-0.07421925,-0.03414697,0.0011145715,-0.012274,0.023022443,-0.024277924,0.017419608,0.14228794,0.059797924,-0.043254476,0.034130502,0.009171416,-0.03301404,0.07106728,0.014237901,-0.0071602836,-0.013066534,-0.019403482,-0.067774154,-0.004239789,0.01297425,-0.031189375,-0.021141838,-0.02847031,0.006345838,0.038206648,-0.0048107966,-0.042807683,-0.05232128,-0.04291383,-0.019143775,0.07543557,0.10273271,0.005625655,0.0019800798,0.0024733571,0.017645527,-0.094442695,-0.060076963,0.14576815,-0.059366774,-0.06293148,-0.026028343,-0.014928506,0.0018747348,0.017665487,0.002538793,0.076080725,-0.049657904,-0.05476232,-0.07401185,1.080298e-33,0.061453506,-0.019329417,0.043481126,0.002420723,-0.0144008165,-0.03269126,-0.12629753,-0.024146624,0.015938247,-0.04274591,-0.012901119,-0.070466176,-0.0028524662,0.034819696,0.011984162,-0.04880951,-0.02804026,0.030288039,0.04312185,0.026149768,-0.044092465,0.012802271,-0.02234403,-0.012996506,0.063669376,0.002347571,0.031074869,-0.0018263573,0.023341244,0.026557703,-0.013461227,-0.07985945,-0.055082686,-0.022943793,0.0362949,-0.013664434,-0.008250583,-0.026735151,-0.079033904,0.11359531,0.046663214,0.00070569926,0.0075902366,-0.071276985,0.041431405,-0.008049551,-0.061529227,0.097397365,0.015837936,0.11011236,0.020248247,-0.03884292,0.10889706,0.018466026,-0.025101185,0.036270462,-0.051748145,-0.00712047,0.01644848,0.039976932,0.11346774,0.04270096,-0.062181804,0.05032249,-0.049284067,0.046100188,-0.083517514,0.005443176,-0.022105178,0.09297699,-0.016277878,0.06349516,0.05898994,-0.016275633,-0.0072524543,-0.012184663,-0.083757885,0.10165311,0.013112245,0.019421913,0.019034714,-0.0042360984,0.03647921,-0.05874587,-0.029223477,0.028550658,-0.012799968,-0.0042516305,0.00031181247,0.048689,0.03465472,-0.088004984,-0.027684791,0.073251605,-0.024519244,-2.8756458e-33,0.09514894,-0.116627,0.054903455,-0.12574455,-0.028061077,0.038671866,0.04189249,0.0495324,-0.04333481,-0.051350024,0.01953237,0.050514694,0.051226184,-0.026133865,0.029321237,0.052463956,-0.035988003,0.011403478,0.0056984453,0.03974453,-0.04792675,0.031089352,0.028020576,0.05668468,0.048107766,0.043103058,-0.05839069,0.07308012,0.06561615,0.027259342,-0.028979538,0.008925176,-0.039504375,-0.0119290715,-0.071888715,0.09036145,-0.043806624,0.06066202,0.07910798,0.046550717,-0.034156736,0.011300317,-0.005849771,-0.0057140696,0.08046531,0.054705765,-0.033656318,-0.0065405145,0.02601683,-0.1074162,0.006591043,0.049851026,0.059360724,-0.012935016,-0.014232751,0.04799995,-0.019322863,0.050605394,0.06343295,-0.10213912,-0.015255254,-0.043756068,0.08052122,0.016270142,-0.018521177,0.089430094,-0.01904786,0.04043172,0.007005476,-0.05861371,0.028863013,0.060611397,0.02786082,0.032145638,0.014716948,-0.0022609027,-0.0054758186,-0.056689,-0.027507823,0.0015901792,-0.031345688,-0.027010454,-0.03146769,-0.09072167,-0.06516976,-0.052681036,0.013708539,0.02574018,0.03846732,0.005029255,-0.04709373,0.021377312,-0.031767774,0.07504464,0.048466887,-4.78836e-08,0.006507587,-0.12561992,0.026469862,0.008559229,0.008669625,0.06291708,0.033927742,-0.04254985,0.065356895,-0.09221811,-0.05919891,0.096525125,-0.01659205,0.040963754,-0.0010606679,0.02437204,-0.03585436,-2.3483257e-05,0.040817283,-0.009278725,-0.09752169,0.0090895025,-0.024017783,0.042171992,-0.027554234,-0.035568476,0.012743609,0.004623891,0.031057352,-0.06872067,-0.021343807,0.07348884,-0.025134822,0.001215339,-0.013372527,0.015901808,-0.06569604,0.0023778228,0.00035830293,0.06354296,0.070302375,0.012925477,-0.081602804,0.0013367909,0.09333904,0.012671993,-0.005772894,0.10298903,-0.020142127,-0.002953657,0.014623654,0.03137642,0.004934443,-0.04233468,-0.062878594,0.017417315,-0.010088931,-0.088465445,-0.028440883,-0.011417516,0.012837026,-0.00089682615,0.21512842,0.04284751 +1.17.1.8,"The substrate of the enzyme was initially thought to be (S)-2,3-dihydrodipicolinate [1], and the enzyme was classified accordingly as EC 1.3.1.26, dihydrodipicolinate reductase. Later studies of the enzyme from the bacterium Escherichia coli have suggested that the actual substrate of the enzyme is (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, and that its activity includes a dehydration step [2], and thus the enzyme has been reclassified as 4-hydroxy-tetrahydrodipicolinate reductase. However, the identity of the substrate is still controversial, as more recently it has been suggested that it may be (S)-2,3-dihydrodipicolinate after all [3].",384,1.0,-0.051930953,-0.108884856,-0.09790601,-0.017122827,0.064258195,-0.013421228,-0.087592885,0.05766676,-9.314064e-05,-0.079803936,-0.039199207,-0.062053103,-0.08027985,0.02429901,-0.040996622,-0.007460832,-0.05608737,-0.02596043,0.06314938,-0.046836916,0.00788005,-0.04209029,-0.012576004,0.014228237,0.05891159,0.039831884,0.09707743,-0.0346346,-0.091047436,-0.068317726,-0.02785583,-0.062050845,0.028616294,-0.09540088,0.07132957,0.111581564,-0.019782264,-0.08526045,0.0063937358,-0.010435901,0.06195688,-0.031501025,-0.00235229,-0.0045994665,-0.06768983,0.02267506,-0.00276129,0.09010898,0.006506579,0.008335275,-0.031795934,-0.055564858,-0.01972192,0.054933187,0.02271942,-0.01482164,0.016895283,0.022737347,-0.038978375,0.061449982,0.06937188,-0.032226425,-0.0046417923,-0.047791723,0.0011615927,0.0054047285,0.027713876,-0.13681954,0.028751994,-0.051481303,-0.07820847,-0.01955761,0.10002832,0.028296525,-0.0044533317,0.0027395221,0.04958663,0.022133995,0.060219485,-0.106707275,0.029203515,0.0032348167,0.009672767,0.06260028,0.017079964,-0.036102183,-0.06756778,-0.023099849,0.04465264,0.052371405,0.023231234,0.057149146,-0.083317235,-0.05866631,-0.06394356,0.09650993,-0.08610617,0.06983333,0.019126642,-0.05656089,0.016318874,0.056544844,-0.0057707247,-0.019491734,-0.015919512,-0.0008985446,-0.020178007,0.10609127,-0.025587022,-0.00023188526,0.003925689,0.011104355,0.07539565,0.014179281,-0.06262662,0.10104092,-0.01903427,-0.0696033,-0.085349485,0.024052411,0.07101592,0.0011939886,0.109060206,0.024412751,-0.0060467483,-0.016677469,-0.08913186,2.9625802e-33,0.044535186,0.014401839,0.014916958,0.010995664,0.008288451,-0.00019374088,-0.0700882,0.051159047,-0.02514964,-0.022720518,-0.006776186,-0.09589084,0.058989234,0.011964314,-0.032630984,-0.047309916,-0.008192874,0.0030073377,0.059230976,0.028820492,0.03912577,0.062006596,-0.036129855,0.003183615,-0.029967695,0.0288193,-0.046968047,0.021963833,0.060652945,0.005150242,0.008783097,-0.1405977,-0.071422055,0.0075392937,0.11380882,-0.008728807,-0.051759552,0.008883194,-0.013005925,0.1007869,0.058124527,-0.012024986,0.034378752,0.011190288,0.068653084,0.018411614,-0.04210283,0.03617341,0.026837494,0.02855301,0.079544514,-0.029416561,0.12909491,-0.07696761,-0.049415488,0.022026092,-0.020513082,0.07925387,0.03914933,-0.009535404,0.008614576,0.13061766,-0.10379007,0.025195213,-0.028681953,0.021825593,0.0026244337,-0.0347314,-0.015497294,0.047269937,-0.043568622,0.043001696,0.06256482,0.039897963,0.03324911,-0.060474746,-0.02896033,0.017442131,0.057315707,-0.04206598,-0.046009183,0.062236246,0.004878894,-0.020158293,-0.08396747,-0.0031453692,-0.017167453,-0.032638278,0.022862181,0.059047706,0.02819471,-0.036929157,-0.055902995,0.0052193925,0.021283392,-3.700464e-33,0.04338498,-0.08239932,0.025710795,-0.040368564,-0.071316585,0.07672699,0.050786912,0.043135166,0.02271051,-0.06405919,0.08722038,0.026769636,-0.022164496,-0.025159596,0.07632526,0.0885262,-0.09862522,0.025563346,-0.012704751,-0.027915828,0.049802534,0.054934513,0.008585021,0.070719704,0.047833335,0.023693144,0.060954694,0.02730993,0.1275055,0.03921451,-0.028111178,-0.015468833,-0.0026808567,-0.0078662485,-0.05092495,0.04844085,-0.09426023,-0.08137381,0.01762388,0.05806282,0.014830538,0.04533148,-0.02945739,-0.009953803,0.013694155,0.059003547,-0.049318105,0.057695746,-0.024170518,-0.058993984,0.018647429,-0.02794509,-0.09257323,0.028752971,-0.0040224358,0.020097556,0.010604737,0.020548869,0.031257503,0.0031145245,-0.04344987,-0.08457791,0.06668895,0.017650453,0.044169445,-0.01582934,0.031855676,0.06776648,0.024725527,0.008582602,0.05755709,-0.022180233,-0.03143735,0.040099844,0.008957659,-0.05294147,-0.014796838,0.005030432,-0.0062265997,-0.014428404,0.041639984,0.030728174,-0.034620963,-0.031000314,0.05440823,-0.07406303,0.06505909,0.13479884,0.003241875,-0.0044441707,0.045015592,-0.04446151,-0.07093019,0.06842241,0.056189783,-4.6343796e-08,0.049988493,-0.036167443,0.05235016,-0.054485608,0.06154606,0.031149492,0.03831595,0.0180701,0.03442651,-0.031888384,-0.032998294,0.03941769,-0.0086043505,-0.033563964,0.019158801,-0.016396204,-0.0549733,-0.019826801,-0.022257226,0.03382705,0.0147132,-0.0413633,-0.17234989,-0.039976038,0.03442745,-0.040557064,-0.055719994,-0.02054204,-0.04117332,-0.023516398,-0.017025208,0.044580717,0.011807873,-0.03838591,-0.029531986,0.0062290565,-0.10099977,-0.04521965,-0.043169953,0.05804666,-0.0039037738,-0.038280636,-0.032675177,0.02357622,-0.050412796,0.0014540256,-0.055518888,0.017231153,-0.019836226,0.008829848,0.013191996,-0.046806563,0.019043012,-0.053919904,-0.099483564,-0.017010238,-0.011422822,-0.07492873,-0.08089177,-0.052855697,0.055217963,0.038597826,0.12628105,0.010869575 +1.23.1.1,"The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that further reduces the product to the lignan (-)-secoisolariciresinol [EC 1.23.1.2, (+)-lariciresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6]. The 4-pro-R hydrogen of NADH is transferred to the 7-pro-R position of lariciresinol [1].",384,1.0,-0.058166098,-0.044261344,-0.17497188,-0.008874065,0.07964475,0.16174442,-0.07226043,0.032008603,0.04261514,0.004249214,0.00046428063,0.0060441243,-0.053985976,-0.056590248,-0.06604383,0.017569821,-0.052346792,0.044196345,-0.022049924,-0.008234067,0.0036770033,-0.038948134,0.043665763,0.037934415,0.046407543,-0.004941519,0.02473152,-0.032206822,-0.055088576,-0.10216743,0.04284763,-0.015808184,0.032870542,-0.102463275,0.030079449,0.03543948,-0.064058565,-0.077296875,0.04725154,0.040778395,0.02424213,-0.05799894,-0.08451838,-0.023202512,-0.07707418,-0.02657635,-0.0005509228,0.06308204,0.04030946,-0.04076635,-0.029730314,-0.03007526,-0.11516677,0.0103381835,-0.06622278,0.011356655,0.031861957,0.039767615,0.023810184,0.07247456,0.08781443,0.00020133845,-0.014349525,0.0075292937,-0.080636896,-0.01239722,0.007821459,-0.04043548,0.053518683,-0.020681128,-0.0010370694,-0.026795605,-3.550385e-05,0.019083636,0.020369,-0.015609909,-0.00043936473,-0.009663608,0.018751381,-0.00075491896,2.9316609e-05,0.0060909204,0.0016930347,0.058624886,0.03086923,-0.013588115,-0.030665118,0.034801792,0.10258085,-0.009181505,0.023399072,-0.010511177,-0.028993543,0.076985195,-0.10870875,0.10602753,0.05876107,-0.04686369,0.0266458,-0.07633821,0.016584564,0.057637285,-0.010525912,-0.095261134,-0.08510486,0.02235382,-0.069152854,0.09404528,-0.0073605115,-0.034566663,0.03479847,0.013140862,-0.018899962,0.045653313,-0.07493237,0.066186406,0.021494614,-0.09604778,-0.11171914,-0.027570276,0.0341614,0.0072684083,0.02204401,0.031097868,-0.010929522,-0.045548383,-0.12485225,1.2097737e-33,0.057481404,0.05582244,-0.056065336,0.014238004,-0.03716316,0.007829333,-0.08320911,0.060607154,-0.05638255,-0.04614745,-0.04900975,-0.03515659,0.036913633,-0.06802394,-0.06377675,-0.0072220936,0.0048653698,-0.0053121564,0.043749075,0.025934467,-0.007609028,0.09515747,-0.057554457,0.042412322,0.018736046,0.029921776,0.04553972,-0.0032720398,0.027557902,-0.00794115,0.016659422,-0.088643484,-0.08416707,0.0309891,0.15469998,0.016432267,-0.09485865,-0.05155571,-0.021870526,0.10011689,-0.023751488,0.098763525,-0.019070664,0.025328707,0.098765865,-0.036653847,-0.0008024932,0.111303344,0.10340801,0.07231507,0.0118353665,0.003466238,0.10003566,0.04707549,-0.078876026,0.034152314,-0.053476293,0.032886315,0.009517357,0.022250615,0.078402825,0.070369475,-0.0046284785,-0.004676504,0.0015539884,0.008662267,-0.10535473,-0.018756278,0.018646179,0.016859341,-0.035344295,0.0043081236,0.05285751,0.010577959,0.051176414,-0.019104755,-0.033938706,0.061109576,0.02286829,0.019221082,0.031543456,0.05426387,-0.009970042,0.025493396,0.0021888772,-0.021561641,-0.013692901,0.00653971,-0.048856795,0.027471479,0.11940699,-0.06736628,0.0134733785,-0.025940686,0.0341201,-1.7458596e-33,0.07483341,-0.112662084,0.07021091,-0.056716137,-0.025036817,0.036334787,0.01029895,-0.06949297,-0.026128126,0.03476601,0.073269814,0.0061792317,0.010715265,-0.025852814,-0.043510847,-0.033932585,0.07830669,0.02996818,-0.076179594,-0.03890272,-0.063331775,0.031023946,0.039337754,-0.06493009,0.018610068,-0.037711557,0.03137521,-0.016346212,0.015536967,0.025599128,0.061620932,-0.028184965,-0.09717462,-0.032675985,-0.0002977226,0.029703245,-0.069462,0.0034034427,0.021753909,0.005224105,-0.042940706,-0.074446104,0.027975012,-0.023838967,0.101904884,0.028335422,-0.08567872,-0.026570456,-0.031434238,0.062187016,0.01727603,0.0018838382,-0.093513794,0.01692418,0.005598879,-0.07514641,0.020959767,-0.010498857,0.02195348,-0.043198165,0.03133316,-0.029682368,0.017682256,0.032302704,0.020238971,0.07145143,0.014063482,0.080891006,0.046736192,0.032565244,0.108036704,0.034705635,0.015699731,0.02026413,-0.053157564,-0.023560887,0.030457985,-0.06519308,-0.0574101,-0.036953248,0.028146641,-0.044340637,0.029828867,-0.087366976,-0.013519639,-0.05870675,0.054043785,0.07019708,-0.018447695,-0.003917897,0.024540117,-0.012477358,-0.01161198,0.018482378,0.116636544,-4.6828635e-08,-0.062019188,0.0026564605,-0.041223377,-0.027665582,0.056423414,0.0012628782,-0.023005886,-0.05244543,0.005425144,-0.01372755,-0.03964011,0.027256733,0.054622646,-0.0042074476,0.059351746,0.012659901,-0.006969276,0.045887206,0.0091742175,0.04147191,0.017325502,0.014758664,-0.15344885,0.048341714,0.0035983152,-0.08300424,0.041572094,-0.048347823,0.09187436,-0.06871497,0.080354504,0.01789205,0.061362755,-0.022932347,-0.04923408,-0.011487907,0.022715231,0.06811641,-0.05049198,0.016899614,0.0142297475,-0.022155657,-0.021152759,0.034996502,0.007967224,0.006125824,0.018551877,-0.009478604,0.0046177018,0.063269414,0.027309349,-0.034820702,0.0077200206,-0.050924405,-0.08165889,0.0458824,-0.0051897853,-0.039089657,-0.041898,-0.037262343,-0.04633646,0.0040495503,0.08541431,0.026670398 +1.23.1.2,"The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (+)-pinoresinol [EC 1.23.1.1, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6].",384,0.99999994,-0.048753638,-0.04025041,-0.12243706,0.082667455,0.07464273,0.071521334,-0.018943354,-0.031678554,0.01825635,-0.0070650317,-0.027404033,0.028639605,-0.076845355,-0.07579609,-0.09575179,0.032220248,-0.072091386,0.042237066,-0.03473004,-0.02436651,0.011700521,-0.038864862,0.02846132,0.054140966,0.0147959115,-0.059197538,-0.0018314841,-0.031392507,-0.044803653,-0.09026068,0.016028522,-0.008140471,0.096006654,-0.094299674,-0.058064066,0.061343156,-0.032796387,-0.12741469,0.0020164342,0.012422493,0.0015210188,-0.023662407,-0.051407114,-0.054056693,-0.04369893,-0.014016634,0.019817894,0.0315017,0.011373553,-0.018453019,-0.013332232,0.0008869953,-0.114473976,-0.0136759225,0.0033523587,-0.04572892,-0.0077360375,0.009843523,0.01930597,0.09443936,0.08960457,0.022424506,-0.015291728,0.029744338,0.008779601,0.026538335,-0.034869496,-0.0070135314,0.08855899,-0.07996106,0.021969061,-0.08967497,0.03983979,-0.05419811,-0.0017135075,0.023628378,-0.031631254,0.03271034,0.06153983,0.031750496,-0.055324227,-0.005208391,0.031111617,0.047249787,0.009005703,0.033257056,-0.05053963,0.05497384,0.055751245,0.0041952278,0.02985601,0.021502184,-0.0005061087,0.083511926,-0.060799755,0.02248966,0.10781227,-0.030046644,0.011707706,-0.020828882,0.017120598,0.034270298,0.013296037,-0.12394336,-0.052534353,0.018614624,-0.02607206,0.05760102,-0.054356497,-0.022683289,0.044592466,0.0211583,0.027614232,0.06620717,-0.048387643,0.009253271,0.050310273,-0.11876041,-0.06615948,0.01381918,0.037943862,-0.014595262,0.046856143,0.0035373843,-0.037826553,0.001224989,-0.11721166,2.3545848e-33,-0.009796437,0.003321062,-0.07715951,-0.020614497,-0.01710845,0.042097077,-0.09099092,-0.005737756,-0.056506466,0.0054205265,-0.03305638,-0.022198034,0.011989764,-0.046956297,-0.034195837,-0.045771133,0.018882172,0.021708604,0.08355887,0.01634551,-0.015752537,0.073671326,-0.11631787,-0.003939831,0.031240644,0.0132917315,-0.017637255,-0.06786923,-0.009521927,-0.0006266094,0.055766884,-0.06715197,-0.109921545,0.010561588,0.07024157,-0.031289976,-0.051515225,-0.025745656,-0.058632333,0.088563494,-0.006388219,0.055043302,-0.024519442,0.01578568,0.09876,-0.0031380786,-0.026820412,0.09866564,0.0949031,0.033807524,-0.0079716565,0.03329216,0.09134029,0.0006354267,-0.062049787,0.041618112,0.003495646,0.048018623,0.05455405,0.045909893,0.00091776566,0.07414712,-0.071239196,-0.010101404,-0.015625183,-0.023439134,-0.056077167,0.05292618,-0.028977243,0.022635218,-0.057791032,0.04900044,0.024913086,-0.042518552,0.015584991,-0.07335106,-0.015269997,0.09863589,0.0072015915,-0.012788611,0.035179302,0.02376991,-0.00024426891,0.017041475,-0.0024126542,0.024173604,-0.016483907,0.040549614,-0.0741235,0.035217732,0.1408402,-0.005144,-0.03984297,-0.05842426,0.08402204,-1.8921047e-33,0.08219478,-0.11328716,0.070180975,-0.05350694,-0.045129467,0.027677935,-0.00042700328,-0.076530464,0.0077364263,0.022716,0.06840187,-0.008928488,0.022893345,0.0038357791,-0.03293585,-0.0039705797,0.060188968,0.06913522,-0.036459614,-0.083662815,-0.108011946,0.0037063046,0.04645525,-0.121709265,-0.022092853,-0.0032908986,-0.007574141,0.037273627,0.004804306,-0.0010435276,0.052213613,-0.012468572,-0.07596271,-0.05004504,-0.013659938,-0.008681779,-0.015169712,0.008836685,0.038854677,-0.0066375947,-0.048322283,-0.020419065,0.044959936,0.027329804,0.08284801,0.053194243,-0.09893395,-0.020502437,-0.032633036,0.064093225,0.050104227,0.030132895,-0.07012151,0.0037235953,0.02845731,-0.06579963,0.0969848,-0.058391795,0.007984757,-0.019960165,0.032189675,-0.07132083,0.07461753,0.033481717,0.07917556,0.07830034,-0.059264764,0.11439072,-0.004920425,0.060555853,0.11610355,0.06689016,0.024958877,0.012473298,-0.00410267,0.023073308,0.0481243,-0.050697822,-0.033057418,-0.054323524,0.051334627,-0.033179548,0.03828357,-0.06273859,-0.003989715,-0.062236007,0.029548975,0.07520138,-0.010220601,0.017201299,0.0058216914,-0.031802718,0.0026560526,-0.046851575,0.1121264,-4.3217472e-08,-0.1195869,-0.03179379,-0.07755952,-0.061856944,0.07900907,0.06625323,-0.08013424,0.015102297,0.007050027,-0.04658863,-0.006692486,0.059892885,0.027929537,0.040225543,0.0831058,-0.034219902,0.013147841,-0.011600761,0.0065482627,0.037752673,0.010123861,-0.00039460437,-0.09460414,0.054537997,-0.014148288,-0.06645959,0.07640851,-0.03893598,0.09250067,0.0052132118,0.018795347,0.043884672,-0.0066327364,-0.007867896,-0.04395874,-0.016770132,0.015875358,0.06005782,-0.10480684,0.004348406,0.00429428,-0.08469234,-0.009552176,-0.0066736573,0.01597718,-0.0446866,0.0037893795,0.017594263,0.027991643,0.034783088,0.07036913,-0.012525389,0.055200677,0.00053633127,-0.05576428,-0.015748492,0.025224209,-0.005293901,-0.004368052,0.010261322,-0.02916264,0.010388389,0.109388456,0.032427825 +1.23.1.3,"The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol [EC 1.23.1.4, (-)-lariciresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1], Linum perenne (perennial flax) [2] and Arabidopsis thaliana (thale cress) [3].",384,1.0,-0.046770927,-0.038342543,-0.17074023,-0.0023628392,0.055199116,0.10582919,-0.07720721,0.026025247,0.067818716,0.01637758,0.06274796,-0.02130408,-0.015131324,-0.057061825,-0.050413076,0.0059987484,-0.068336844,0.07992996,-0.017894028,-0.06259361,0.03355858,0.00054289424,-0.04170295,-0.013418649,0.024935016,-0.042755775,-0.0043223742,-0.060002025,-0.063546106,-0.086732395,0.0064753867,-0.0010638515,0.031939447,-0.066947296,0.04451603,0.046370108,-0.0642603,-0.08236481,0.0662671,0.008518954,-0.00056196883,-0.05087427,-0.051536907,-0.03110323,-0.06293285,-0.047998477,-0.0498897,0.046888027,0.012565954,-0.039712254,-0.023103815,0.0024184345,-0.13330829,0.04453582,-0.05274713,0.04094591,0.005260431,0.013372646,0.03191566,0.07987005,0.10730737,-0.015793731,-0.02737763,-0.025701437,-0.046245705,0.002621442,-0.0067849713,-0.025081048,0.074753314,-0.00838613,0.032754317,-0.038356755,0.006628801,0.0028959294,0.050028775,-0.03181921,-0.02214,0.040057212,0.0064633754,-0.0020607922,0.03154574,-0.012727231,0.0155438995,0.064287595,0.051428344,-0.0074323756,-0.06772268,0.039222535,0.10870458,-0.0029315178,0.023181006,0.042302445,-0.03347857,0.020283628,-0.091818675,0.08265537,-0.00041046433,-0.026006881,0.008506579,-0.058334056,0.023963882,0.021074774,-0.027917882,-0.122179635,-0.09250135,0.019586522,-0.023233924,0.054416593,0.012592741,-0.037058365,0.019582663,0.05042473,-0.03334101,0.044468902,-0.037945613,0.060105246,0.04775082,-0.09282421,-0.10292034,-0.062457494,0.036625106,-0.0062441477,-0.013180902,0.01926667,-0.016727915,-0.047953166,-0.1178583,2.4431263e-33,0.047067676,0.10713685,-0.066853315,-0.052329507,0.007731176,-0.010373226,-0.034003723,0.06835571,-0.06316844,-0.025126887,-0.06284477,-0.03023762,0.009425821,-0.037940357,-0.056253254,-0.033828076,-0.0072222124,-0.0065342607,0.077251,-0.04389134,0.009847784,0.09119349,-0.052678857,0.042276543,0.0075858296,-0.0046810242,0.008333816,-0.0050357287,0.037862618,-0.007626038,0.021939544,-0.09114836,-0.035406888,-0.0045983437,0.15526935,0.0002466193,-0.07912156,-0.010612637,-0.039720837,0.09723806,0.0065972395,0.08951849,-0.012704621,0.029063001,0.11135682,-0.029223545,-0.05655258,0.13528329,0.0988909,0.034450587,0.005899843,0.010002102,0.10577117,0.033357076,-0.098068155,0.032670535,-0.03271858,0.0032950884,-0.025520995,0.032261275,0.029241364,0.02445498,-0.029856533,0.0061923065,-0.038991887,0.040301077,-0.094377786,-0.01339017,-0.0076527875,0.0063309576,-0.046515472,-0.011445925,-0.0010956548,-0.025695607,0.064676344,-0.052561987,-0.008588388,0.09087827,-0.017155891,0.00705826,-0.0005153727,0.04973423,-0.0365545,0.022444103,-0.004526106,-0.025184644,-0.03555725,0.009157105,-0.0053175543,0.042843495,0.108992465,-0.055949062,-0.026196001,0.01936142,0.04277969,-2.4795275e-33,0.041163348,-0.14002006,0.056877997,-0.069520645,-0.017653435,0.036785852,0.0031931207,-0.018286172,0.004564326,0.027432868,0.041618872,0.0052783014,0.015489129,-0.01876573,-0.036319904,0.022053698,0.0925635,0.077631816,-0.05849898,0.01051642,-0.08359246,0.0411551,0.05172462,-0.041930154,0.047291797,0.025145724,0.012054768,0.051597714,0.028713211,0.0055912305,0.05436468,-0.04150513,-0.065774314,-0.05610039,-0.046023805,0.063449904,-0.075903445,-0.007240443,0.022643233,0.016994307,0.026129523,-0.041333433,0.004629416,0.053100664,0.085508585,0.013195722,-0.064249136,-0.00622887,-0.0980859,0.035642948,0.033639215,0.027059523,-0.072079286,0.037138112,0.015012478,-0.058385413,0.058056254,0.008225998,-0.010683303,-0.041062724,0.025751932,-0.059553836,-0.009483819,0.016956475,0.118907966,0.067426234,0.020548057,0.114881024,0.03345093,0.040245663,0.10334309,0.049117595,-0.05232765,0.014135017,-0.043236054,-0.0386404,-0.018613998,-0.041764945,-0.07320519,0.0020160652,0.010273298,-0.020952882,0.030171072,-0.093758546,-0.023737507,-0.07091396,0.035091907,0.11025064,0.007901386,0.051197696,-0.003714284,-0.024971701,0.0042379657,0.03700546,0.1295894,-4.70958e-08,-0.027375609,-0.0047207247,-0.038388986,-0.04293182,0.03291943,-0.008952107,-0.005110493,-0.0137960715,-0.01280212,-0.0326817,-0.06575109,0.018819444,0.08249975,-0.026770009,0.06825536,0.019557808,0.020546813,0.04725629,0.008384567,0.008831164,0.01192078,0.026065849,-0.11506679,0.07407225,-0.023660282,-0.054340586,0.03297922,-0.067311786,0.07136618,-0.038187075,0.059483565,0.026095148,0.026833659,-0.031775545,-0.067611665,0.006815147,0.037723176,0.018334169,-0.020499192,-0.007924386,-0.060037836,0.026234929,-0.0627703,0.055419073,-0.01964464,-0.033944055,0.04148554,-0.024357298,0.049537268,0.04026457,0.0041354187,-0.07122983,0.0004895745,-0.0753148,-0.110038996,0.0072545204,0.004167126,-0.005497491,-0.02205858,-0.010752461,-0.033929165,0.004822341,0.12884347,0.025521364 +1.23.1.4,"The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (-)-pinoresinol [EC 1.23.1.3, (-)-pinoresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1] and Linum corymbulosum [2].",384,0.99999994,-0.0047358945,-0.0380143,-0.14574483,0.025057055,0.05236647,0.051282335,-0.008833197,-0.02107393,0.026533756,0.028162492,0.055854607,0.005183732,-0.058189604,-0.07639136,-0.09456085,0.04114248,-0.05353281,0.019292863,-0.0002462461,-0.020531686,0.05543556,-0.0372238,-0.03373343,0.041391272,0.016001482,-0.06738279,0.028224645,-0.054914556,-0.09475025,-0.10382393,-0.015412726,-0.0049451073,0.07959657,-0.067653075,-0.006756192,0.061804067,-0.09264936,-0.09232938,-0.0076343804,-0.010411175,-0.007400586,-0.030788997,-0.014337927,-0.03402614,-0.078800626,0.005210679,0.01200205,0.025210451,0.02726866,-0.02366893,0.01769821,-0.0034111124,-0.07713385,0.010084384,0.04657364,-0.031460483,-0.022289854,0.018240362,0.02962774,0.05545274,0.07964256,0.017214483,-0.022127796,-0.015587584,0.014041783,0.015325823,-0.016623927,0.0017591891,0.06717347,-0.059282165,0.032566197,-0.065945566,0.05078977,-0.045490406,0.01020272,-0.0040415176,-0.004332392,0.026614156,0.043680787,0.011601039,-0.021731155,0.014135376,0.019307574,0.053667173,-0.00989503,0.0634318,-0.06287326,0.04737741,0.072764955,-0.033591103,0.050308663,0.06597546,-0.0074620913,-0.025236396,-0.062370416,0.011732391,0.03453266,-0.0132704815,0.039658446,-0.012868039,0.05145402,0.045565393,-0.0048529305,-0.2130567,-0.09969192,0.040030994,-0.031183327,0.054018285,-0.022579927,0.01130838,0.027600141,0.0072864746,0.016120821,0.07154997,-0.051631194,0.0100785075,0.10313601,-0.09903745,-0.12632747,-0.015044001,0.006416387,-0.035586305,0.0455882,0.013393867,-0.024900861,-0.014362923,-0.12353992,1.4420121e-33,0.03625259,-0.013476423,-0.07241805,-0.061726827,0.062390044,0.010793625,-0.02737858,-0.04068888,-0.044305302,0.021649731,-0.06458856,-0.09325269,0.014641491,-0.04571035,-0.05460563,-0.021390673,0.031632278,-0.005148611,0.05930187,0.0042202463,-0.019245418,0.07044558,-0.09262863,-0.020270078,0.025288776,0.017712258,0.0020613868,-0.060278356,0.050241314,-0.022809384,0.03624124,-0.06956569,-0.072652526,0.008469361,0.06993617,-0.042021856,-0.033464532,-0.017928885,-0.04973144,0.07315004,0.035300326,0.050462075,0.0060451636,0.01781259,0.12002565,0.0037732578,-0.056770273,0.09326423,0.057854943,0.04675889,-0.009850498,0.007861675,0.12334216,-0.02426388,-0.0629669,0.015981821,-0.014475803,0.032591548,0.055314925,0.067536,-0.035033226,0.07091203,-0.07995519,-0.018757448,-0.027563056,0.03523475,-0.097601034,0.0128283715,-0.02322311,-0.002530013,-0.06092755,-0.05506984,0.003774519,-0.055597864,0.005823626,-0.04665262,-0.038043927,0.062009126,-0.00909194,-0.018075787,-0.04538875,0.04161139,-0.017854769,0.0065687075,-0.0012586024,0.03532233,-0.041069437,-0.020202942,-0.066926144,0.041052986,0.129149,-0.0047683422,-0.047664165,-0.029733786,0.06889892,-1.7528257e-33,0.06345811,-0.10216333,0.03957939,-0.072542764,-0.016456068,0.031679776,0.00064929266,-0.040751804,0.011710137,-0.020492578,0.04642103,-0.0033580821,-0.014763474,0.03913207,-0.009702852,0.046668135,0.096501894,0.15137824,-0.06353386,-0.06341154,-0.09608151,0.034511615,0.066520326,-0.06787048,0.0093242405,-0.018830184,0.0032316782,0.10135323,0.029514005,-0.015938615,0.062387113,-0.016449127,-0.055609778,-0.050843116,-0.056838106,0.016314656,-0.036957733,-0.027901279,0.044022102,0.060142867,-0.030442886,-0.014894298,0.023271667,0.043604404,0.026906874,0.020193666,-0.10129262,0.016800167,-0.051095176,-0.02404274,0.048329316,0.0069901217,-0.024011951,0.0046544913,0.037361134,-0.0016910034,0.108739346,-0.018997462,-0.007440783,-0.035460427,0.010417289,-0.1273801,0.054844685,0.04556667,0.093915984,0.088808835,0.0027052688,0.09160044,-0.0018294621,0.015116343,0.10161173,0.08485331,-0.02149032,0.07335415,0.0003901348,-0.027405731,0.00590742,-0.024975969,-0.0024266343,-0.021881094,0.00079590833,-0.04798083,0.020115122,-0.08214546,0.03175319,-0.062127605,0.03488605,0.06370333,-0.032890107,0.03803308,-0.011898958,-0.029647442,0.0090162745,0.043668535,0.1224287,-4.223455e-08,-0.04112252,-0.050675374,-0.050267942,-0.08073514,0.054071147,0.069800615,-0.029283635,0.06271008,-0.0058226692,-0.048641462,-0.03672195,0.054495484,0.03223074,0.034788966,0.118333556,0.029392147,0.03260445,0.009058693,-0.019885415,0.022270773,0.021893112,-0.009500639,-0.122443296,0.093133,-0.024918325,-0.05527268,0.07741602,-0.0020749862,0.0010477816,0.014905214,0.018087829,0.04820315,-0.011585379,-0.041434716,-0.0041730567,0.033674374,0.015160019,0.0477566,-0.033001862,0.034929954,-0.061286055,-0.046728425,-0.03941097,0.009032076,-0.025923781,-0.07318781,0.029408293,0.04218949,0.013111119,0.020575128,0.06871371,0.008084416,0.023438204,-0.0431125,-0.027100043,-0.02681469,0.04104117,-0.029269623,0.018516818,0.047354612,0.026241507,0.022058876,0.1229895,0.006792095 +2.1.1.266,"The recombinant RlmJ protein is most active in methylating deproteinized 23S ribosomal subunit, and does not methylate the completely assembled 50S subunits [1]. ",384,1.0,0.019787677,-0.068030894,-0.08545871,-0.061219536,0.024505587,0.00825378,-0.033483814,0.037947264,-0.016098425,-0.00011213691,0.01324378,0.038641244,0.043063775,0.05354135,0.041152295,0.022677762,-0.027891481,0.04242284,-0.027101098,-0.021973502,0.009613482,0.046025958,-0.0127008725,-0.04073945,0.015461606,0.04385968,0.06626603,0.0051493593,-0.02967274,-0.07428179,-0.0009986422,0.04756725,0.016283846,0.008273679,-0.03820125,0.05123529,-0.060520004,-0.01006236,0.087648675,-0.025787242,0.0050081103,0.010766747,0.058239277,-0.020308696,0.01076099,-0.036983427,-0.09710695,0.10060642,0.021693338,0.0186477,-0.015155269,-0.031475857,-0.0101250885,0.08282867,0.03660623,0.026406024,-0.086354405,-0.048553206,-0.035940524,-0.06702973,-0.014753927,-0.047635704,-0.053153254,-0.026527077,-0.029416079,-0.07327045,0.03919963,-0.049131893,0.025745302,0.036919743,0.056934018,-0.037547696,-0.04237489,0.031286497,0.019711152,0.056274924,0.084719196,0.023889964,-0.008958385,-0.04144704,0.006821924,0.01953621,0.11000137,-0.0039057068,-0.0028158308,-0.021759955,0.033481702,0.061911486,0.04343923,0.040475827,-0.009646582,0.023880392,0.027255543,-0.036892,-0.10192559,-0.0009365528,-0.012433469,0.017459093,-0.04141024,-0.026432404,-0.005131979,0.06502001,0.03380946,-0.008069376,-0.051438317,0.015402293,-0.0037286899,0.10937949,-0.077524886,-0.030804982,0.0155233,0.022009652,0.05141547,-0.018210214,0.043516602,0.015204411,0.03986154,0.0041718055,-0.008489891,-0.043933313,-0.03389858,0.016735021,0.037824336,-0.01922806,-0.045781095,-0.021819992,-0.16853534,3.6510575e-33,-0.011033921,-0.03095751,0.026740061,0.043304287,-0.026526429,0.0590852,-0.042161826,0.03841435,0.022498518,-0.08493345,-0.123245925,-0.08826896,0.096254736,-0.00894304,-0.06494426,-0.028398762,-0.006340189,-0.03262913,-0.08235374,-0.013347453,-0.02020941,0.085699104,-0.052838117,-0.05435691,0.009165896,0.021604275,0.09944668,-0.08036937,0.0037496544,0.0069048875,-0.05153526,-0.023239702,-0.08771831,0.08224455,0.051284883,0.037807472,-0.004395569,0.021431247,0.039069287,0.0026600345,0.06670431,0.013125983,-0.068459876,-0.038529586,0.031027308,-0.008909053,0.026641948,0.034755353,-0.06401967,0.10644047,0.05850256,0.04078452,0.05158452,-0.030296983,-0.101076014,-0.016511282,-0.0072768987,0.032484204,-0.006420844,0.04637182,-0.05400702,-0.024657093,-0.027233673,0.074781485,0.043709673,0.007085014,-0.052353114,-0.121887304,0.003652646,0.07585141,0.01216791,-0.010708562,0.17039835,-0.10806762,-0.022800477,-0.06400179,-0.028912652,0.04227663,0.09251691,0.101982884,-0.03459077,0.027917614,-0.06901305,-0.07121575,-0.012861762,-0.047357816,0.033323634,-0.058224175,-0.027998418,0.024276955,0.13210005,-0.06313161,-0.026147278,0.030854838,0.008722094,-4.3360835e-33,0.05350945,-0.06315978,0.046520207,-0.012081813,-0.017670453,-0.037068415,0.02667262,-0.014040582,-0.04637576,-0.12024689,0.12668815,-0.0077273226,-0.05713758,0.051170092,0.023655955,-0.01950839,-0.034223743,0.01931026,-0.018520439,0.033355754,-0.0124245025,0.03685772,0.044654693,0.074161366,0.0036472916,0.024240253,-0.0023375333,0.097125575,0.043739527,0.008914491,-0.017928876,0.054178875,-0.027414773,-0.047523424,-0.010072113,0.07147596,-0.010744063,0.020576805,0.016404891,-0.032562982,-0.0048155044,0.06813033,-0.09263276,0.085713826,0.0249761,0.01868638,0.029528793,-0.00031027914,-0.012839392,-0.10614111,0.005995711,-0.041731093,0.0052604126,0.05063117,-0.008262999,0.023155352,-0.02584645,0.044770997,0.05839094,0.037194073,-0.05933596,-0.0636189,0.023490626,0.0185552,0.031471517,0.031479973,0.071941525,0.043802373,0.055958156,-0.044987008,0.00781179,-0.0105698155,0.01848454,0.02178173,0.018469943,-0.1352026,-0.060539354,-0.016219145,-0.08893736,-0.043909315,0.005431678,-0.06946705,-0.057595637,0.022142202,0.07482865,-0.11713843,-0.011854727,0.013643974,-0.060848914,0.025390008,0.0134851895,0.031989653,0.01428555,0.14728798,0.119248375,-3.1757363e-08,0.045528337,-0.02619217,-0.051496502,-0.0611225,0.026016997,0.07104687,-0.05879076,-0.013940138,0.019002827,0.043153197,0.02345734,0.012488994,-0.07795016,0.079966746,-0.018314557,0.014131213,-0.10825314,0.0033549431,0.009796857,-0.0014286072,0.0018148455,-0.012279637,-0.024172448,0.014639212,-0.051822025,0.019698083,0.011198751,0.003983156,0.047902964,-0.11001488,0.0053837444,0.08463115,0.050108705,0.074574456,-0.03965768,-0.05388135,0.06897474,0.031359233,-0.00042068303,-0.01808959,-0.0015840321,0.028809084,-0.08559108,0.008437282,-0.0137368115,-0.061662726,-0.06292089,0.07331618,0.0052942596,-0.06913065,-0.0313739,0.08308592,0.013742236,-0.07974119,-0.07435825,0.023974573,-0.08153517,0.0060107065,0.02730721,0.03556389,0.011469775,-0.01993189,0.02735104,-0.0957463 +2.1.1.267,"Isolated from Vitis vinifera (grape) [2]. Most active with delphinidin 3-glucoside but also acts on cyanidin 3-glucoside, cyanidin, myricetin, quercetin and quercetin 3-glucoside. The enzyme from Catharanthus roseus was most active with myricetin [1].",384,1.0,-0.04412021,-0.089237005,-0.14570788,-0.016925512,0.013709649,0.07605831,0.007036918,0.068891644,0.063400894,-0.034799572,0.04829047,0.0061375247,-0.0329531,0.019845808,-0.048185136,-0.007866378,0.04049358,0.037262276,0.011290933,-0.07106667,-0.011906433,0.07899507,0.0012681208,-0.016896836,0.038530167,-0.014118388,-0.05729175,0.046138775,-0.03323418,-0.04474401,-0.07923556,-0.032337952,-0.004822834,0.012684809,-0.048458602,-0.0002298483,-0.058067005,-0.1075254,0.018664733,0.04412845,-0.026839402,0.043360144,-0.043545164,0.020914627,0.024624523,-0.010868911,-0.080437005,0.03744949,0.06284819,0.035813853,-0.0380074,-0.015501665,0.053944193,-0.004122534,-0.018017326,-0.09068733,0.005164687,-0.030537562,0.032309998,0.07312408,0.073574565,0.015679438,0.06258451,0.021374919,-0.07469238,-0.0014433623,-0.037969016,0.05889191,0.026769059,-0.07231372,-0.05168823,-0.02510691,-0.05646127,-0.03783035,-0.035522092,0.11207015,-0.028929872,-0.010825202,-0.052009556,-0.0022035316,0.02291468,0.027267598,-0.0534478,0.12504885,-0.016794039,0.04249362,-0.018428842,0.045547463,0.006334533,0.059659265,0.042266402,0.027485596,-0.01940379,-0.05908828,-0.005601252,-0.004611562,-1.891138e-05,-0.08333212,-0.06911117,0.04233127,-0.066076465,-0.04925068,0.045835026,-0.060985025,-0.14197354,0.10819393,-0.04845846,-0.008580605,0.08054182,-0.0119840875,-0.05317673,0.018416483,-0.026102675,-0.035993934,0.015446086,0.09826616,0.12909707,0.020149983,-0.0040278137,-0.02623006,-0.015604525,-0.01068931,0.05654224,-0.019413771,-0.036934968,0.042637505,0.019131167,4.1659975e-33,0.037204392,0.01256249,-0.019945545,0.032967843,0.034879643,0.017447291,-0.010207571,0.04431995,-0.047022454,-0.02668327,-0.102608405,-0.07113463,0.07435653,0.022984082,-0.06728079,0.06312113,0.0847568,-0.11212221,0.027035205,-0.061439943,0.107086584,0.051881324,-0.054146644,0.0056175706,-0.0693872,0.011542225,0.045381516,0.024507836,0.04653442,-0.03386075,-0.0372093,-0.07504771,-0.02054815,0.0016065426,0.08989915,0.032703385,-0.08425236,-0.045701243,0.04398741,0.045797955,0.03182547,0.034517087,0.07613964,-0.03476835,0.047631443,-0.041084755,-0.10339209,0.06414546,-0.042011112,-0.009905524,-0.0040674587,0.026130678,0.033897333,-0.0013129235,-0.054766983,0.016801,0.03853118,0.06879083,0.0085304575,0.01613501,0.009892374,0.020924259,-0.029026465,-0.0093488395,-0.03568285,0.06337131,-0.13764594,-0.018972522,-0.04605818,0.045943968,-0.0056800246,-0.00020536405,-0.018115511,-0.071266755,0.075214356,-0.04504963,-0.08795385,-0.034759473,-0.014222479,0.042897463,-0.078963995,-0.032053854,0.025024923,0.04839545,-0.020209461,-0.00557384,-0.016712282,-0.00929074,0.05385545,0.03407119,0.044928133,-0.011062229,-0.013686331,0.0086794505,0.07084151,-4.002165e-33,0.019523539,0.012856768,0.104865,-0.046073165,0.009744221,0.047991537,-0.06439772,0.0010469591,-0.046594452,-0.04417434,0.04212028,-0.003225524,-0.010712671,-0.032043397,-0.04020893,0.06970978,0.041686065,0.059028164,-0.06732162,0.007264601,-0.085697815,0.010012583,0.03857753,-0.035010166,0.082474336,-0.0443326,0.014868152,0.0276655,-0.044059984,0.048083533,0.031297993,-0.027769227,-0.036398023,-0.04594858,0.016472971,0.021109875,-0.022527002,-0.091775015,0.06298466,0.006094387,-0.012073136,-0.0062969765,0.019812115,0.105063565,0.03524659,0.11337692,-0.097462445,0.044533975,-0.062836915,0.07156877,0.022772433,0.063832864,0.026552211,0.047360264,0.07227189,0.007708195,0.08889445,-0.0062310062,-0.018398227,-0.013395462,0.045511384,-0.016855296,-0.040039405,0.0050548026,0.08991596,0.015822588,0.027684458,0.07880071,0.034100983,-0.12992562,0.06327933,-0.02849036,0.027662106,0.037454415,-0.0027291141,-0.059079643,-0.014065805,-0.02062329,0.014021858,-0.025606891,0.021231696,-0.048332185,-0.038729616,-0.045527093,0.03482653,0.011811662,-4.246489e-05,0.034179788,0.01554373,0.019143842,-0.019811898,0.076146126,-0.044990055,-0.020389725,0.070032254,-3.3412896e-08,0.08435025,-0.029214583,-0.023407156,-0.05305676,-0.04266122,-0.03452172,-0.009753805,0.098255076,-0.021864412,0.048859075,-0.016232617,0.023191271,-0.0019088939,-0.025395868,0.07081234,0.020862224,0.09337157,0.025308488,0.0032617834,0.050813764,-0.011817621,0.053085454,-0.07121511,-0.037100814,-0.045022573,-0.103851646,-0.012041573,-0.037581578,0.07186531,-0.057587646,0.014606354,0.009221653,-0.031590547,-0.066347785,-0.08981293,0.10621547,-0.053817976,0.043534804,0.011738937,-0.01379118,-0.030673327,-0.03086134,-0.06898252,-0.028418876,-0.10939052,-0.051735513,0.0468577,0.032345247,0.0027662446,-0.037716415,-0.0023020105,0.02250935,0.1070765,-0.0006568372,-0.093916036,-0.027331453,0.07282672,-0.06501919,0.0027526654,-0.058281496,-0.074913844,-0.09658241,0.08923142,0.04805863 +2.1.1.268,The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer. 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+2.3.1.211,"A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.",384,0.99999994,-0.09069514,-0.0066646994,-0.096502095,0.036720812,0.056639045,0.05316491,-0.13353238,0.0009220475,0.026568158,-0.0036550618,0.05755085,-0.085365884,0.00918251,-0.10065551,-0.09256375,0.011323603,-0.07449662,0.031373553,-0.05730397,-0.030619845,0.039479036,-0.0152071165,-0.0255038,0.068873644,0.037991825,-0.04855172,0.016167285,-0.059933625,-0.0056057065,-0.06981889,-0.0152053535,0.0919965,0.030316869,0.024688238,0.032227043,0.11857265,-0.014746231,-0.011710672,0.06535019,-0.056788884,0.06599845,-0.043928917,0.01840795,-0.016594928,-0.0018323098,-0.04763249,0.010226776,0.021482367,0.0007008655,-0.031212542,-0.064737014,0.014392245,-0.04023777,0.084955424,0.0062947823,-0.046317585,-0.031476755,0.009295472,-0.0010343652,0.10503782,0.0748134,-0.03034948,-0.04907431,0.019817816,-0.012423377,-0.082495466,-0.060112473,-0.0030017027,0.07263551,0.022585096,-0.068031825,0.04596192,0.019060696,0.012494435,0.037235454,0.038962852,0.03328405,0.021662943,0.01377106,-0.07190479,0.018141968,0.09120027,0.057776134,0.042565584,0.06656208,0.03644658,-0.0049775424,0.019749258,0.08926518,-0.024675593,0.067512356,0.010858492,-0.030824795,-0.043908708,-0.039791074,0.0007893716,-0.03191755,0.01743551,0.027814725,-0.017934393,-0.0134098055,0.06558501,-0.062343,-0.05849169,-0.074239455,0.020398948,-0.025614679,0.0032685231,0.044398718,0.034138322,-0.012036416,0.020463593,0.025720796,0.023935204,-0.03594138,0.08255847,-0.04528863,-0.11425277,0.059935484,-0.048301604,0.0058438056,-0.07194285,-0.050658286,0.05964391,-0.060392655,0.066296406,-0.0033683234,3.494029e-33,0.030993657,0.06389112,0.044358395,0.0354266,0.045890227,-0.02136138,-0.058424626,-0.008115269,-0.08258071,-0.039954226,-0.0727538,-0.0058751283,-0.06586425,0.10236787,0.030298272,-0.049559575,-0.025909444,0.015200354,-0.009577075,-0.06438808,-0.010427767,0.021693127,-0.13230191,-0.0025437598,0.04565073,0.0731201,0.039637048,0.032560784,-0.004455448,-0.040420264,0.01425251,-0.0068397596,-0.0105262175,0.059141286,0.0058027976,0.0033131854,0.00293244,-0.0072428547,-0.0031610068,0.11190045,0.012273851,0.03236851,0.009485715,0.008217776,0.067975655,-0.050446194,-0.074499816,0.09014281,0.058048245,0.032308076,0.039002683,0.08239941,0.10292147,0.0054704943,-0.012339871,-0.009189279,0.05408762,-0.055562723,0.034909666,0.045817163,-0.061823238,0.03491526,-0.06146908,0.005280906,-0.022542372,0.03384033,-0.10374787,-0.03332713,0.055207342,0.010206156,-0.056894265,-0.033668574,-0.025532255,0.061017934,0.03842766,-0.055777308,-0.090999216,0.018864114,0.0014075438,0.036172718,0.035270803,0.03544239,-0.055044945,-0.03531646,-0.06866832,-0.03265434,-0.12593336,-0.038582716,0.016453814,0.017379908,0.027863504,-0.027044034,-0.02455565,0.087424584,0.017139047,-4.0158465e-33,0.051636904,-0.070246726,0.049048178,-0.03286504,-0.06050252,-0.0032840227,-0.070668064,0.03189069,0.022985151,-0.023897892,0.08861259,-0.06283375,0.07589396,0.03022813,0.0054633087,0.012009947,0.054732464,0.11844476,-0.043732125,0.018795485,-0.025942089,0.10723843,-0.03565531,0.013852695,0.036622122,0.018509533,0.05440322,0.08090654,-0.034017704,0.04418576,-0.05501484,-0.12704754,-0.062463302,0.052407064,-0.0506112,0.009714914,-0.0856131,-0.032336887,-0.027501868,0.06601368,0.008248796,0.0076516857,0.039284837,0.07164459,0.0024978109,-0.024948971,-0.07447833,0.07593233,-0.004115189,-0.0047507607,0.08983321,-0.0023431482,0.025096538,0.029207384,0.059997607,0.03274832,-0.028173685,-0.02361511,-0.069252476,-0.073145606,-0.00724474,-0.032491874,0.0083330395,-0.025056986,0.037193656,0.05784062,-0.058885653,0.12879087,0.033378396,-0.0188028,0.037848014,0.00792765,-0.02499556,0.040659808,-0.045188703,0.0037927018,-0.0774636,-0.042377606,-0.04553623,0.0459604,-0.046453055,-0.035466533,0.047851607,-0.09102609,-0.035561547,0.005021928,0.06463613,0.06741649,0.04949682,0.11113562,0.0006166486,-0.0021582735,-0.014430089,0.11255546,0.10303673,-4.2069622e-08,0.019339755,-0.13805716,0.002257337,-0.07533631,-0.03812009,-0.041950077,0.011086999,-0.04113449,0.003850616,0.0026574929,-0.06522166,0.08328181,0.009549242,-0.0026566265,-0.035622984,0.021816954,0.091153026,0.01681186,0.0021939403,0.020524718,-0.05453998,0.0033590358,-0.042840358,0.018556636,-0.014251052,-0.04162559,-0.006343766,0.041760586,-0.01245427,0.013138773,-0.006894692,0.020346936,0.0031650322,-0.02322022,-0.032923713,0.04083213,0.0016521872,-0.06487658,-0.0053376635,-0.0014731314,0.037024174,0.02905193,-0.020193666,-0.0051719877,-0.04295124,-0.039084353,0.0035217702,-0.026564097,0.004208689,0.042007677,-0.021283377,-0.035457876,0.045783166,-0.12288068,-0.081989884,-0.022311201,-0.026676787,0.016056063,-0.013891022,-0.019772025,-0.022410164,0.0028115448,0.19859429,-0.014844201 +2.3.1.212,A polyketide synthase that catalyses the C6-C4 skeleton of phenylbutanoids in higher plants.,384,1.0,-0.00881606,0.005313359,-0.02172082,-0.05269497,-0.0022398445,0.117590666,-0.12132962,-0.0018931422,0.021186186,0.021975424,0.023037767,-0.10052832,0.013387767,-0.07710642,-0.090263456,0.047137797,-0.16426219,0.10633023,-0.019907152,-0.016382515,-0.028034754,0.033793684,-0.009033408,0.0071606673,0.058943003,-0.07740526,0.0068726656,-0.0745052,-0.0019282281,-0.005619173,0.022831017,0.06434755,0.0029409414,0.006922335,0.002700584,0.079634175,-0.041857593,-0.05484838,0.13011383,0.061027903,0.008271693,0.031527966,0.038221527,-0.06424509,-0.022576643,0.023397679,-0.049731534,-0.019591205,0.05324253,-0.052977443,0.011405189,-0.045844506,-0.030560713,0.026212482,-0.0022911725,-0.016129186,-0.03235895,0.030853312,0.10492753,0.05577663,0.08729229,0.013949236,0.056439232,-0.025296029,-0.019404499,-0.041257795,-0.06504394,0.056512695,0.045513406,-0.049228076,-0.1069771,0.02883575,-0.004844529,-0.0044726883,-0.03921273,0.040749457,-0.07629542,0.016829418,-0.010342549,-0.019617569,0.015720276,0.040289134,0.037151806,0.007022068,0.06875812,0.056410648,0.039021228,0.041091118,-0.011915515,0.043947376,0.05354182,0.010437166,-0.031242775,-0.039728153,-0.03590581,0.013118251,0.016573226,-0.027744967,0.073451065,0.009112581,0.0027892096,0.0036552479,0.019687857,-0.087463446,-0.011560066,0.0152508225,-0.06715191,0.029766137,0.021644935,-0.01203729,-0.028799582,-0.016023282,-0.028989635,-0.05931491,-0.021842273,0.05105522,-0.03875818,-0.048134584,-0.04308158,-0.05487327,-0.010355263,0.016523765,0.013556418,0.02110049,-0.0326672,-0.04158524,-0.102778874,5.1120335e-34,0.0970903,0.0884998,0.07651929,-0.009682145,-0.00445708,-0.061394975,-0.076639265,0.0032145754,-0.054049484,-0.08408234,-0.07770581,-0.08456587,0.008538381,-0.006040448,0.064635895,-0.043856844,0.009079121,-0.028821643,0.037828583,-0.07311769,-0.053291757,-0.0100055775,-0.055990577,-0.0014915619,0.014856369,0.06564711,0.035919197,-0.018353537,0.0010088538,-0.06280748,-0.04209819,-0.021448426,-0.026964836,0.0905706,0.014965468,-0.04849667,-0.018614722,-0.090702005,-0.012575693,0.02631045,0.00502243,-0.02447997,0.014525445,-0.022912106,0.10462345,0.04092715,-0.039654635,-0.0065571843,0.009439953,0.08291658,-0.003931386,0.09295916,0.11689134,0.07577031,-0.070464775,-0.028112808,-0.029947199,-0.0657022,0.012863212,0.06634455,0.009077278,0.035546806,-0.013527177,0.011006011,-0.007932263,0.07544455,-0.045925874,-0.010085095,-0.0020307135,0.03108435,-0.00780298,-0.15024203,0.0655745,0.048654594,0.102301784,0.024005093,-0.06666796,-0.02341785,-0.060694475,-0.020584876,0.03302899,-0.0012215954,-0.017083446,-0.018676601,-0.004169087,-0.010766929,-0.06842829,-0.046569936,0.041628607,0.05642494,0.06495386,-0.12578109,-0.032434337,0.050753944,-0.032217115,-1.3821955e-33,0.10123,-0.01725427,-0.01816085,-0.061227176,-0.047065154,0.0404096,-0.0075663948,-0.060653064,-0.09570779,-0.03490437,0.0040451977,0.020898718,0.01923119,0.008409018,0.009660687,0.023315925,0.12302538,0.065267354,0.009952731,0.0024160824,0.023395702,-0.0027037289,-0.06583651,0.03910392,0.02437259,0.07173366,0.052904315,0.007607751,0.044964116,0.03274377,-0.04709714,-0.04771405,-0.010264361,0.05075586,-0.012640116,0.026266959,-0.05582932,-0.038934976,0.010892436,0.12874155,-0.03518445,-0.029134385,-0.007961369,0.05499411,0.052804798,-0.019805683,-0.031185195,0.064202584,-0.045738067,-0.008167278,0.049871624,0.0788529,0.05580626,-0.058247298,0.0058770385,0.004654991,0.028558927,-0.050290976,-0.01730511,-0.040663954,0.008402098,-0.07585514,0.040231142,0.044151343,-0.074001536,0.061829995,0.005454658,0.08323396,-0.051589683,-0.007802405,0.088819556,0.0025054663,0.053927302,0.06764294,-0.018283218,-0.01729894,0.008545639,-0.082387835,-0.037759636,0.026227985,-0.02729166,-0.003406023,0.070702575,-0.057255667,-0.003592887,-0.03043507,0.017111422,0.0035037494,0.032725144,0.04761409,0.04329827,0.038557343,0.01645133,0.09418482,0.094908744,-2.3501867e-08,0.05680703,-0.044668615,0.014607651,-0.09533329,-0.0040147975,-0.031170549,-0.013914475,0.026977817,-0.054594338,-0.051893063,-0.037327055,0.021442145,0.0010717218,0.037457593,0.0632907,0.0019296774,-0.014391192,-0.035868786,-0.036154907,0.030858006,-0.123311445,0.050074793,-0.10411309,0.013633399,-0.0063467086,-0.08860902,0.0446307,0.11371963,-0.0031912022,0.06266852,0.06943207,0.07841626,-0.04402705,-0.085655004,0.018034706,0.04278085,0.04924548,-0.08294043,-0.016589817,-0.0127396,-0.02188975,-0.017202914,-0.03690167,0.01905965,-0.0038869823,0.003681178,-0.021781292,-0.012426848,0.033327978,0.009278008,0.039276775,0.0741217,0.00012387801,-0.053050026,-0.045046225,0.013905625,-0.0048891725,0.009114995,-0.012204525,-0.04149388,-0.11695243,-0.034758363,0.1830912,-0.008040814 +2.3.1.213,"Isolated from the plant Daucus carota (Afghan cultivar carrot). In addition to 1-O-(4-hydroxycinnamoyl)-beta-D-glucose, the enzyme can use the 1-O-sinapoyl- and 1-O-feruloyl- derivatives of beta-D-glucose. +",384,1.0,-0.10455832,0.020250535,-0.15630735,0.031800855,0.012251333,0.015029082,-0.030138817,0.03490478,0.06070244,-0.05085212,0.06470092,-0.031379573,-0.10594464,-0.02447096,-0.023129264,0.016780348,0.040699095,0.055054445,0.0302216,-0.056889795,0.035152428,0.055617165,0.0608648,0.0017562425,0.061415955,-0.0754275,0.017566374,0.01210277,-0.031880155,-0.07163646,-0.016529918,-0.046119988,0.046648245,-0.00076208817,0.036071405,0.047715046,0.0041223546,-0.056102574,0.00995393,0.012055772,0.02833474,-0.0014289401,0.01862075,0.010067141,-0.016679857,-0.050358217,-0.14994712,0.06923111,0.05916064,-0.019224698,-0.038319707,-0.030425148,-0.05691838,0.00016626861,0.045626886,-0.007827259,-0.018617043,0.025616547,0.017615607,0.08077971,0.047681812,0.037033863,0.0027321493,0.0043502464,-0.09365507,-0.0037110283,-0.021787677,-0.058563996,0.048429646,-0.02169105,-0.031820256,-0.083045006,0.040785927,0.020035364,-0.047326475,-0.0441213,-0.06934331,0.064465374,0.07038864,-0.01596893,0.034199297,0.016398745,0.058734603,0.0608745,-0.017050117,0.053741764,-0.021858452,0.037396777,0.013022112,-0.01968544,0.02729325,0.0074627125,-0.10681649,0.009778157,-0.01414654,-0.07113638,0.13383532,-0.04793279,-0.015479507,0.033906084,0.009679291,0.02284098,0.04978948,-0.07433425,-0.098516494,0.038195536,0.013059016,-0.021751469,0.028315801,-0.01989711,-0.040244214,0.04892216,-0.01685548,-0.04456862,-0.097764835,-0.037951794,-0.051512476,-0.08555054,-0.013233741,0.011170657,0.002284514,-0.05249965,0.044230312,0.033694897,0.011296037,0.05104845,-0.053200193,-2.0186623e-33,0.075004674,-0.013767283,-0.036566168,-0.048601046,0.00819462,-0.04082082,-0.027171738,0.03067964,-0.015322626,0.03935287,-0.09191324,-0.09107296,-0.043543357,0.01582716,0.020564187,-0.033633642,-0.023018934,-0.024409773,0.09764873,-0.011493999,0.013657118,0.043277185,-0.023469586,0.06085982,-0.018631337,0.03352226,-0.061998658,0.0026675994,0.11211485,0.03442333,0.045730416,-0.1067851,-0.019950766,-0.018009432,-0.03136561,0.004299034,-0.13068609,-0.050729647,0.056835108,0.07831175,0.095780075,0.024976019,0.081021674,-0.061710175,0.026327182,0.06416992,0.024254093,0.110787965,0.04956887,0.03776116,0.00075801695,-0.017921293,0.0011814734,0.04560949,-0.057974983,0.0643429,-0.06145734,-0.015634358,-0.010307071,0.044456024,-0.044573184,0.030487787,-0.001324505,-0.023820976,-0.013303815,-0.024575794,-0.1596232,-0.049273893,-0.037494857,0.012413248,0.029926786,-0.061956756,0.01315879,-0.048297074,0.00808269,-0.033491693,0.03013967,0.04262334,0.002953198,-0.04433109,0.020770324,0.042107545,0.021049986,-0.04827073,-0.016063606,0.04746721,-0.054242317,-0.048611563,-0.012411,0.081635475,-0.055975884,-0.005185493,-0.045952372,-0.053124968,0.07614552,-2.7373998e-35,0.010462369,-0.031613726,0.066864476,-0.046865482,0.0126805045,0.091381155,-0.015272759,-0.0637218,0.06685041,0.011204938,-0.012770398,0.0777951,-0.0062392573,-0.09407717,0.029075997,0.10530721,-0.06778303,0.11336286,-0.024918485,-0.0077409903,-0.08770409,0.048557304,0.014712135,-0.04248894,0.08244799,0.005570747,0.04425857,0.021939028,0.09567468,0.032441534,0.04246921,-0.018411025,-0.029741714,0.04604479,-0.039040614,0.017816383,-0.04120253,-0.042202312,-0.024732145,0.087957986,-0.058482215,0.025085745,0.00012190409,0.010649457,0.11150362,0.03443297,-0.017268497,0.03155368,-0.051817223,-0.01019132,0.040014762,-0.012068201,-0.041750938,-0.024237946,-0.00080362457,0.043267857,0.082995296,0.05354423,-0.07091844,-0.064706504,0.023987694,-0.03900106,0.026662944,0.02443274,0.039565735,0.06682082,0.078984134,0.041090887,0.017307494,0.055584576,0.020425446,0.021866975,-0.028969035,0.006783147,0.015350223,0.0023498114,-0.039907984,-0.0075109177,-0.051311016,-0.06303977,-0.006059682,0.019236432,-0.009864389,-0.06007382,-0.03933621,-0.016879877,0.049322397,0.07577157,0.029732656,0.10807427,-0.07258342,0.049602956,-0.058939863,0.023559522,0.104131624,-3.3272148e-08,0.06965896,-0.04307218,-0.009387479,-0.043217238,-0.012220608,-0.016287452,-0.02807866,-0.016625173,-0.006877133,-0.015077109,-0.061454374,0.13473506,-0.051766813,0.011929973,-0.0100979805,-0.021471217,-0.0059061702,0.07115484,-0.024423867,0.06567242,-0.06834022,0.06699331,-0.054586515,-0.014494373,-0.034472898,-0.09655972,0.042258773,0.0022021432,0.06107239,0.060924686,0.058986455,0.07430438,-0.025537262,-0.13210638,-0.008791908,0.0017249356,-0.07498571,-0.0005208556,-0.020589683,0.0422383,0.008332852,-0.046411954,0.02158261,0.037218515,-0.08658242,-0.020392757,-0.013444466,-0.023128176,-0.01568327,0.03748051,-0.022370974,0.009963212,-0.0815992,-0.081099965,-0.06256589,0.012174928,-0.010463002,-0.04917927,-0.017531805,-0.040477987,-0.08359547,0.016095093,0.14522348,0.020828307 +2.3.1.214,Isolated from the plant Salvia splendens (scarlet sage). ,384,1.0,-0.0014263755,-0.017579408,-0.10371677,0.047597673,0.13178508,0.09067667,0.0196256,-0.025181843,0.028738994,-0.020838907,0.102850035,0.039464407,-0.027953435,-0.031902824,-0.0014537893,0.06691034,-0.018858187,-0.039534274,0.003802822,0.071741894,0.07060521,0.010076916,-0.034873772,0.057332408,0.0147087965,-0.008728631,-0.022143478,0.04724553,-0.037174113,-0.07956109,0.020070244,-0.038438566,0.089327276,-0.093836896,0.014217142,-0.017019052,0.027948128,0.02394617,0.09055083,0.040602084,-0.046715733,-0.012913969,-0.027503468,-0.0151902875,-0.033093914,-0.055011284,-0.05109221,0.008350626,0.057832643,-0.03613952,-0.02921252,-0.043451924,-0.018564792,0.047152456,-0.006517995,0.046718877,-0.03699558,-0.034649044,0.022578109,0.026607286,0.05124147,0.0053597973,-0.048384037,-0.048515096,-0.05975123,0.00966483,-0.022263655,-0.047335327,0.11019041,-0.07859427,-0.0014792538,-0.044994608,0.003057541,0.07119512,-0.015831552,0.027461084,-0.0060413666,-0.0038551083,-3.9097627e-06,0.041624278,-0.057278216,0.036821026,-0.021629803,0.032444943,0.04161833,0.016918527,0.019213572,0.04709329,0.00879884,-0.046196837,-0.02392467,0.006178592,-0.014902535,-0.031547092,-0.037576757,0.04861104,0.02354241,-0.01563625,0.00021964288,0.027968125,0.06793514,-0.024338618,0.0051950477,-0.12967882,-0.042743765,0.1046118,-0.09087585,-0.06236243,0.031533375,-0.05942225,-0.031267114,0.009233158,-0.03869645,-0.029728564,-0.0035198608,0.039019614,0.069798104,-0.0010780892,-0.056771584,-0.001966839,0.006901832,0.057339072,0.09593806,0.025304087,0.03447565,0.058906544,-0.041971542,1.3643646e-34,0.04963318,-0.014536747,0.014662453,0.029293273,-0.011134584,-0.022243982,0.0068748146,0.04926126,-0.0054180413,-0.062123124,-0.047222026,-0.10670709,-0.0010091689,-0.071626656,0.0033883136,0.0029152927,0.078534484,-0.047755867,0.07439699,-0.017013818,-0.08670858,0.07975511,-0.024115307,-0.019995812,-0.041051816,-0.020730432,0.028858684,-0.06490042,0.093088716,0.025675893,0.11378114,0.0048028575,-0.036022626,0.030743346,0.05181668,0.03235713,-0.062485702,-0.05000925,0.030407952,0.071260996,0.047436975,0.025942652,0.08835225,0.08651318,0.033697274,-4.7354326e-05,-0.060031638,0.027146326,0.14281216,-0.028836649,-0.07338758,0.018238278,0.0380368,0.052843798,-0.06523417,-0.027936492,0.02861769,0.019622386,0.0058798133,0.029103406,-0.03592154,0.04709163,-0.029623693,0.007773352,0.035395596,0.011427726,-0.12742862,0.019413197,-0.0437352,-0.033639967,-0.023730233,0.025439827,-0.0017264868,-0.035282027,-0.027444618,-0.031080509,0.0017322828,0.025929613,-9.2253766e-05,-0.026464866,-0.05530739,0.022277698,-0.0073554968,0.10599066,-0.087962076,-0.040535655,-0.07957362,0.031613804,0.0026621262,-0.0066716657,0.018463077,0.018598795,-0.10875142,-0.092334196,-0.04901104,6.470925e-34,0.041430224,0.024685,-0.012512196,0.026293661,-0.030210866,0.10848405,-0.055195805,0.0600955,-0.043667845,0.008672281,-0.04369349,-0.0321438,0.028761262,-0.06300523,-0.008448139,0.11215921,0.05913862,0.11488436,-0.04116339,-0.04117515,-0.11473331,0.056709066,0.012766768,-0.019236922,0.03157051,0.031609576,0.033290792,0.003675209,0.0625541,0.0011367504,0.09456732,0.011938176,-0.0865763,-0.08989907,-0.06804998,-0.032322418,-0.029069403,-0.065513864,0.0019377819,0.044328704,-0.027585568,-0.008204783,0.03466221,0.03445501,0.103261545,0.045622252,-0.014441869,0.05369657,-0.05571341,0.03685801,0.050622575,-0.032831,0.022006318,-0.015586164,0.033801295,-0.10435797,-0.03806222,0.03514959,0.035875488,-0.086487934,0.051651232,0.080613,-0.10894577,0.0047526923,0.05578229,0.055483647,0.008016477,0.033559464,-0.08437914,-0.024021385,0.012871738,-0.010583054,0.022474108,0.022553472,0.020867284,0.06400229,-0.031493593,-0.053526487,0.01580913,0.05451317,0.02150654,-0.045828465,0.03643426,-0.059824366,0.009293021,0.00478989,-0.01630604,-0.021786317,0.029568853,-0.019498646,-0.036646724,0.06515656,-0.05390545,0.005685994,0.13171533,-1.6042316e-08,0.17211989,-0.05384567,-0.063971855,0.00091363373,-0.025249785,-0.019460222,0.027517864,0.054303017,0.038579684,0.06531007,-0.10227117,0.013261213,0.06292151,-0.019289233,0.006057487,0.0068223565,0.12863128,0.050296817,-0.023935854,0.02179495,-0.051236514,0.019827785,-0.015978502,-0.016053915,-0.048810378,-0.10905726,0.07910351,-0.0047347504,0.07537181,0.0034799757,0.042357545,-0.004945682,-0.022604337,-0.03724214,-0.0033086606,0.089957975,-0.019701108,0.005810422,0.064614594,-0.0015148075,-0.063796066,-0.04481279,-0.024182793,0.00053745403,-0.043551225,-0.067171186,-0.053324126,0.03229765,-0.001968329,-0.042468864,-0.042155597,-0.018114058,0.029128665,0.003227022,-0.1321072,-0.029947061,0.052793287,-0.08330317,-0.003792782,-0.058737535,-0.04891811,0.00794697,0.0276187,0.09220243 +2.3.1.215,"Isolated from the plants Perilla frutescens and Gentiana triflora (clustered gentian). Acts on a range of anthocyanidin 3-O-glucosides, 3,5-di-O-glucosides and cyanidin 3-rutinoside. It did not act on delphinidin 3,3',7-tri-O-glucoside. Recombinant Perilla frutescens enzyme could utilize caffeoyl-CoA but not malonyl-CoA as alternative acyl donor.",384,1.0,-0.09552341,-0.07108622,-0.13887982,0.017067222,0.10594338,0.053039193,-0.014484048,0.07673207,0.09316456,-0.08091017,0.05811316,-0.09107803,-0.055918522,-0.017720116,-0.09414378,-0.0039397855,0.0027002913,0.06922695,0.003913426,-0.033389926,-0.0007696862,-0.032851834,0.013306647,-0.0094132,0.00489352,0.020050617,-0.034730844,-0.045738664,0.007326206,-0.08117941,-0.063546084,0.009806858,0.027037984,-0.014460358,-0.008415388,0.10560689,-0.018590134,-0.018866679,0.008470852,0.016411122,-0.049123496,-0.014941974,0.0032017357,0.041963495,-0.030822612,-0.053827245,-0.029395027,0.053945735,0.045500252,-0.022372045,-0.021191921,-0.021753356,-0.019803068,0.039114676,-0.008987845,0.001059799,-0.013522612,-0.060740925,-0.02450529,0.08763389,0.043842398,-0.022637395,-0.0071399626,-0.009602122,-0.118734926,-0.0012943057,-0.0062096356,-0.004114744,0.070271164,-0.079062276,-0.0042763944,-0.03401725,0.06615375,-0.018311402,0.0059065847,0.16494265,0.011121407,0.038893253,-0.024334846,-0.017456755,-0.0143677965,0.010009836,0.032528087,0.083225474,0.016001357,-0.036443908,-0.0005711524,0.009183171,0.015284101,0.039686766,-0.0063549,0.13837469,-0.008526755,0.010159539,-0.08522578,0.08062173,0.05522143,-0.040809702,-0.024299975,-0.016550194,-0.048811603,0.021260124,0.064436436,-0.022711558,-0.07969268,-0.012738114,-0.07391711,-0.07081517,0.087817244,-0.039134525,-0.034819875,0.019509342,-0.07330577,0.018131504,-0.026695631,-0.0013307458,0.001853793,-0.062070105,0.031023862,0.028586032,-0.089525804,-0.0058518397,-0.024362484,-0.024350928,0.035869233,0.054676708,0.022755977,6.190074e-33,0.019636877,0.068076335,-0.0774806,0.030440204,0.034254726,-0.0015011359,-0.0036781253,0.046524107,-0.0059846616,-0.013481459,-0.05669504,-0.080669634,-0.020764636,0.041477546,-0.047122043,-0.020056179,0.04899407,-0.07830887,0.09231777,-0.041186985,0.106494136,0.06923239,-0.080453075,-0.029323198,0.00608221,0.057750497,0.017884864,0.04633078,0.080494165,-0.001419894,0.01728601,-0.061810605,0.036532,-0.004758786,0.009532958,0.024709025,-0.07743733,-0.036046058,-0.019739408,0.13516423,-0.03475405,0.033927627,0.031796794,-0.06343475,0.09146728,-0.037728317,-0.107079744,0.099693954,-0.0059077297,0.064773366,0.026571516,0.0059977327,0.05487576,0.07410837,-0.035596106,-0.040079046,-0.10859474,0.04137029,0.03963042,0.011122084,0.031275798,0.051590595,-0.0013306736,-0.045887347,0.06343375,0.053241026,-0.11241822,0.0039049643,0.0052443263,0.002118716,0.02457495,-0.03758003,-0.016596995,0.03834107,0.083180346,-0.023661066,-0.03698969,0.082524985,0.068774536,0.008436579,-0.037497897,0.009255933,0.076316714,0.032062147,-0.040015575,0.019797908,-0.048185453,0.021899225,0.012231908,-0.0326885,0.08882586,-0.01869953,-0.010975951,0.0021656177,-0.0020381045,-4.5736674e-33,0.07647094,-0.034789607,0.031804517,-0.068901114,-0.0017571672,0.050801776,-0.03344561,-0.025788445,0.011259074,0.026889468,0.025925007,-0.01405874,0.038458742,-0.05946097,-0.08699157,0.036885187,0.038676232,0.03899193,-0.06412857,0.031042531,-0.09517185,0.012149592,0.036926057,0.013058497,0.06785095,-0.02949222,0.047519807,-0.037371974,-0.09997605,0.040726278,0.073272645,-0.002725687,-0.025702596,-0.031090876,0.019474398,-0.03530283,-0.04762239,-0.0072575375,0.0518687,0.029886914,-0.019114554,0.015217463,-0.0052294997,0.040218532,0.038377244,0.04544103,-0.09478366,-0.009431496,-0.00557285,0.022693846,-0.03388769,-0.0055300817,0.0073663956,-0.020603275,0.03153339,-0.029596237,0.107782684,-0.016909625,0.026176887,-0.049152747,-0.02724777,-0.07699693,-0.0309717,0.04317431,0.11468241,0.0868067,-0.03777067,0.09980493,0.04178859,-0.011938445,0.068279505,0.0024233449,0.057744145,0.010084989,-0.037597883,0.03338295,0.054762904,-0.056299113,-0.01709102,-0.01620384,0.05979856,-0.05519156,0.0014828184,-0.045933943,-0.07671443,-0.06456727,0.05071226,-0.0037164784,0.006428886,0.036964126,-0.05183096,0.056209374,-0.02990782,0.020955766,0.2128753,-4.4326953e-08,0.03912852,-0.034783475,-0.03378798,0.0086961305,-0.0056458185,-0.0061587305,-0.06713052,0.017716506,-0.016989678,0.05206538,-0.0524659,0.091363445,0.004663466,0.010302703,0.013029989,-0.021015424,0.1020099,0.039482445,0.010681627,0.0047753276,-0.11822439,0.035929438,-0.050374925,-0.024978133,0.03519223,-0.10045994,0.09545486,-0.077002324,0.037313033,-0.014651576,-0.019434951,0.0012350541,-0.038586948,-0.00136317,0.018582242,0.03146736,0.0013031369,0.0022176702,-0.051057447,0.018872201,0.034006916,0.019100655,-0.015379502,-0.013851063,-0.03937849,-0.078892596,-0.03311372,0.0035741227,-0.00297269,0.026728159,0.042904966,-0.034393992,0.017255517,-0.06035931,-0.040868115,-0.045470763,-0.0098874355,-0.00083264394,-0.033776037,-0.045767322,-0.112037495,-0.012228343,0.15442538,-0.012856034 +2.3.1.216,A polyketide synthase from the plant Aloe arborescens (aloe).,384,1.0,-0.048741374,0.021178063,-0.034384552,0.02459749,0.053538904,0.03602058,-0.04560024,-0.070399,0.028496208,0.058842864,-0.01405823,-0.120319284,-0.008187849,-0.10999548,-0.11977224,0.09608843,-0.073400654,0.05591853,0.024590898,0.020500403,0.061393816,0.06693659,0.006826287,0.0048999446,0.02520146,0.014670436,-0.012678942,-0.06875835,0.017151278,-0.07326101,0.022384277,0.04667801,0.011434844,-0.014028615,-0.022449447,0.082229614,-0.023858566,-0.023862697,0.06736156,0.07210445,0.11810977,-0.0023725037,0.020199873,-0.052614383,-0.07721042,0.07126236,-0.023165612,0.04475764,0.0177818,0.021288825,-0.04864586,-0.11141344,-0.06335383,0.0039331266,-0.0015615358,-0.0014033383,0.039055247,0.088368684,0.036364403,0.04600216,0.10870519,-0.0013790522,0.034035478,0.03828316,-0.012086473,-0.00093916326,-0.05788348,-0.023673704,-0.045514595,-0.06281664,-0.08302685,0.007029355,-0.02984777,0.044996176,0.043917954,0.10795105,-0.016588232,0.00058346835,-0.021763302,0.009076932,0.00087850867,0.0474057,0.04038846,0.031342,0.048805587,0.05366801,0.07880203,0.06275856,-0.031455673,-0.024616258,-0.056906145,-0.018337961,-0.08832,-0.029056208,-0.01367796,0.050230023,0.0029335856,0.027142642,0.017300988,-0.008812751,-0.06681083,-0.026693456,0.033673223,-0.13890886,-0.06361308,-0.0023170307,-0.042000517,0.024411118,0.052109342,0.022758937,-0.051574018,0.025681216,-0.042475082,-0.03494322,0.0023586205,0.033012737,0.008594127,-0.042302694,-0.010104338,0.0053689294,-0.008953876,-0.022052186,0.010386694,0.08870321,-0.04035029,-0.011953958,-0.05455768,-2.7505748e-34,0.05930118,0.050515607,-0.016051201,-0.01873567,0.030021694,-0.0073593813,-0.051590413,-0.014573791,-0.045121513,-0.07385698,-0.03465648,-0.077484034,0.025739877,0.056155443,0.09828617,-0.051314764,0.010609205,-0.047135036,0.053662185,-0.119529456,0.010324788,-0.038169425,-0.12765275,0.07107026,-0.040094662,0.06850416,0.049390405,-0.06043469,0.03745836,-0.07152426,-0.057977397,-0.045169406,-0.045954533,-0.017663272,-0.04807019,0.0019849287,-0.012674321,-0.10332132,-0.006234934,-0.023096701,-0.005421697,-0.013553318,0.10392008,-0.04712864,0.10216339,-0.0018486585,-0.06794355,0.0065399385,0.045610186,0.021621272,-0.009288316,0.048754957,0.13086607,0.007901077,-0.11402759,0.031065844,-0.04483274,-0.03852714,-0.060931463,0.05656461,-3.9265396e-05,0.02333671,0.011926822,0.028907206,-0.09546168,0.07910477,0.024347214,-0.06359116,0.048712555,-0.00728435,-0.051150315,-0.03746056,0.054642066,0.0054373713,-0.06247855,0.0226567,-0.050230704,-0.060664717,0.02745014,0.005351997,0.0022394166,0.0009836004,-0.036086276,-0.008409993,0.0035609077,-0.06771349,-0.05887319,0.0807877,-0.036031734,0.05687321,0.043819945,-0.04536368,-0.049888566,0.029967505,-0.010788063,-1.4754755e-33,0.05804412,-0.027715107,0.023579178,-0.06732651,-0.05265419,0.025149189,-0.04055724,0.034041625,-0.034019124,-0.052609168,0.026904246,-0.044135295,0.11015691,-0.04845169,-0.07336349,-0.041601334,0.05601137,0.053118322,0.05123466,-0.054439243,0.060776956,0.08609551,0.018892417,-0.034540027,0.031141743,-0.014133109,0.038590726,0.12022091,-0.013818475,0.049913943,-0.004963449,0.01701398,-0.013647653,0.016499188,-0.02079269,0.050312832,-0.043658312,-0.05241538,-0.006766612,0.05196433,0.005576678,-0.023836423,0.02590623,0.1027234,0.05198992,0.08635995,-0.05117741,0.026965657,-0.006033453,-0.00061856356,0.005571741,0.073570386,-0.011318388,0.034416698,-0.0040284884,0.04561554,0.010410629,-0.014519454,-0.06304338,-0.08158781,-0.03636931,-0.013240717,0.060058687,-0.018674696,-0.04890629,0.093383536,-0.06006958,0.016456116,-0.0223223,0.081520446,0.1491598,0.046489872,-0.061463244,0.09486996,0.019982181,-0.06275283,0.001910382,0.01672413,-0.09866863,-0.035928406,-0.02974839,0.023081781,0.012761451,-0.030131813,0.024846425,-0.00089047855,0.011762679,0.025693074,-0.027332395,0.07725265,-0.030188467,0.034330606,-0.07148986,0.07290007,-0.0072637014,-2.1549354e-08,-0.029452994,0.031113543,0.049071517,-0.07529511,0.009911695,0.033523183,0.04844046,0.022079227,-0.032889936,-0.0882649,-0.054636296,-0.007372363,0.0027535679,0.06486105,0.12511642,-0.01784622,0.03119739,-0.016292661,-0.0035724635,-0.043187357,-0.017387442,0.015144524,-0.03261794,0.044019572,-0.031085128,-0.04171108,0.054896023,-0.0018334042,-0.008695364,0.08820236,0.020787528,0.08765466,-0.018858658,-0.06493719,-0.034618687,0.090872034,0.011711145,-0.031758435,-0.012419076,-0.017787479,-0.020336656,-0.0009288663,-0.0057132873,-0.004047525,-0.009259349,-0.037357062,0.009365301,-0.028603343,0.0769154,-0.03935971,0.04948616,-0.006505244,0.012746871,-0.06175606,-0.074881844,-0.016247272,-0.021175498,-0.05565847,-0.0022355958,-0.021496126,-0.049552787,-0.039059717,0.18283875,0.013856745 +2.3.1.217,"A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well [2] (see EC 2.3.1.219, demethoxycurcumin synthase).",384,1.0,-0.0790309,-0.048262686,-0.122046255,-0.020000216,0.076047376,0.06170213,-0.119234666,-0.02651914,0.043421336,-0.034492813,0.013118568,-0.14466347,-0.04743524,-0.08052988,-0.068437,-0.013691188,-0.0617209,0.056854155,0.028546643,-0.037857253,-0.021999525,0.00855297,-0.040362924,0.050747458,0.02934348,-0.005940718,0.015969092,-0.066139765,0.033337504,-0.130371,-0.016448312,0.053579014,0.06821684,0.007479255,0.004010573,0.10028993,-0.089737855,0.0024914835,0.009226895,-0.012340905,0.05511961,-0.019166846,0.06873224,-0.016139766,-0.0887969,-0.0365781,0.03113962,-0.005358396,0.032362986,-0.008410521,-0.027952539,-0.013828427,-0.049857512,0.06897593,0.02391373,-0.06409764,-0.046498355,-0.015248372,0.026465587,0.073556304,0.09183208,-0.023352006,-0.03161438,-0.015182698,-0.03535009,-0.018130053,-0.0010803747,0.030030448,0.021999368,0.0049827653,-0.048704475,0.044279255,-0.092616074,0.016952058,-0.032327835,0.12908238,0.02510671,-0.013542782,0.033849362,0.006419048,-0.024163403,0.13095663,0.06378227,0.033470858,0.056546446,0.066457756,0.0014525106,0.013233675,0.040208224,-0.024312975,0.022528868,0.059521586,-0.008940538,-0.022633253,-0.03761233,0.017718773,0.015031134,0.008574966,0.035249475,-0.041646697,-0.012147782,0.038361825,0.019644756,-0.039418988,-0.06569107,-0.013165491,-0.051435843,0.03040266,0.049348254,0.08419681,-0.033426266,-0.0007108459,0.0027390523,-0.027560813,0.026312005,0.048209693,-0.03896208,-0.10319196,-0.0017480621,-0.0030759692,0.02626672,-0.0782584,-0.035782687,0.020949405,-0.015169467,0.0054289494,-0.0031441667,5.0242987e-33,0.044294894,0.13699847,0.028486049,0.04720042,0.045337748,0.0035201234,-0.065126054,0.028303139,-0.08283565,-0.024187211,-0.04881658,0.03590864,-0.066029996,0.11281247,0.028203601,-0.07140974,0.02884009,-0.019773398,0.0037123733,-0.09991193,-0.0111945765,0.060791943,-0.091362454,0.018156145,0.026633559,-0.004013748,0.04707635,-0.012578445,0.032321088,-0.058678184,0.011860894,-0.0034721305,0.011883459,0.038762596,0.018957216,-0.034437608,-0.025567198,-0.00509731,0.011578544,0.12191146,0.068614945,0.026139265,0.04089936,-0.02507282,0.08568019,-0.08072231,-0.10020004,0.035596322,-0.0072464943,0.020915108,0.03169654,0.11862271,0.024929298,0.04343989,-0.01455515,-0.014892821,0.0187575,-0.010915779,-0.001653063,0.021833817,-0.05582823,0.04084581,-0.03192587,0.008992495,-0.0465659,0.019376054,-0.070321955,-0.028351082,0.04132105,0.034219883,-0.022797639,-0.04205134,-0.037572574,0.059106737,0.07389163,-0.050593086,-0.09865318,-0.022254162,0.042226814,0.0170005,-0.023277892,0.05618174,-0.038264155,0.0081365835,-0.061731398,-0.105046324,-0.08354205,0.05005617,0.009985601,0.025817428,0.012000415,-0.023053791,-0.014279227,0.0483922,-0.009759788,-4.9809406e-33,0.089487955,-0.09269153,0.07811845,-0.05225012,-0.075500615,0.024871651,-0.039213788,0.012441507,0.025666725,-0.012193204,0.10971579,-0.023298115,0.067114934,0.005529959,0.012289862,-0.025981147,0.070131436,0.11710178,-0.082109354,-0.042742364,-0.03330722,0.037516203,-0.016453069,-0.011584951,-0.0039646807,0.027592842,0.055949174,0.034752555,-0.013056213,0.08531653,-0.06400831,-0.07492935,-8.781772e-05,0.08196088,-0.09172274,0.010419841,-0.024392731,-0.013795817,-0.03815827,0.06326044,0.07939631,0.0069488245,0.079728276,0.09510636,0.0024161593,-0.033127416,-0.04862606,0.05740024,-0.012582208,0.018042307,0.07380173,0.019797456,-0.016376395,0.020898176,0.07720162,0.009137921,-0.005903951,-0.057438307,-0.047477607,-0.041074507,-0.023720266,-0.029584838,0.023015663,-0.05020626,0.05394991,0.039389353,-0.056514736,0.124566406,-0.006992669,0.013282192,0.09596319,0.044845108,0.018419174,0.02602437,0.008289078,-0.06159349,-0.051396456,-0.0028594295,-0.04389603,-0.021890113,-0.022878358,-0.06846889,0.05881744,-0.07137454,-0.040448774,0.021060428,0.05828018,0.030092062,0.05034425,0.082282215,-0.034305036,0.035331693,0.0065690097,0.13042364,0.077091426,-4.18915e-08,0.016576117,-0.06001662,0.028510721,-0.09221742,-0.041712448,0.044008274,0.009418844,-0.023441998,-0.025607845,0.016550537,-0.04437832,0.098752625,0.012754554,-0.0037816959,0.019971875,0.045455474,0.06331314,0.019396793,0.018933857,-0.017797487,-0.05349657,0.08342864,-0.04954781,0.008551929,-0.08935443,-0.018284427,-0.0084308805,0.028113838,-0.0060208435,0.028807133,0.03740859,0.051140342,-0.0072302436,-0.03978596,-0.024838096,-0.037252013,0.028970078,-0.0825264,-0.022969024,0.0042158486,0.047621902,0.061662592,-0.0849777,-0.024441965,-0.036853172,-0.02253635,0.007591912,-0.037071154,-0.04016956,-0.013771917,-0.02945039,-0.0038922315,0.010949023,-0.10490611,-0.064745285,-0.017543646,-0.04982443,-0.0015766359,-0.057101756,-0.04717245,-0.05960835,-0.055043712,0.14519307,0.03435674 +2.3.1.218,"The enzyme has been characterized from the plant Curcuma longa (turmeric). It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA.",384,0.99999994,-0.04104855,-0.06374318,-0.15780538,-0.016524136,0.05204931,0.06399579,-0.15456526,0.023172837,0.010805851,-0.026758863,0.055878993,-0.088619694,-0.066631176,-0.0031872995,-0.04922929,0.015002733,-0.022647792,-0.038126662,-0.0007102519,-0.049979594,0.0010208733,0.034091238,-0.022081112,0.042222142,0.027220247,0.0064524203,-0.0065477686,-0.02278794,-0.0067647314,-0.09349133,-0.052572723,0.04613621,0.0709708,0.0050617205,-0.009543762,0.07484744,-0.11680463,-0.03762677,0.022965135,-0.03756521,-0.0033751277,-0.022037413,-0.013119818,0.028577106,-0.09222294,-0.09857302,0.061223794,0.018143956,0.06378549,0.08085391,-0.05346829,-0.030460313,-0.050135143,0.09903099,0.0025672838,-0.04208523,-0.044939414,-0.04006906,-0.04427219,0.07172854,0.060776085,-0.0007004969,-0.07055516,0.05131028,-0.043607138,-0.05309126,0.020594873,-0.0025307727,0.03774537,-0.02070511,-0.0043608574,-0.035214778,-0.02407522,0.043182872,0.004689684,0.07270318,0.017115599,-0.024492519,0.023004511,0.006832901,-0.016274601,0.10348918,0.051802494,0.032067105,0.10555028,0.040928762,-0.021590926,0.026618134,0.04924367,-0.020628082,0.08566077,0.08027552,-0.053590618,-0.042306043,-0.05494428,0.028759383,-0.029701123,0.0076132133,-0.060629033,-0.018670619,0.0030611581,0.084610954,-0.025266979,-0.058664557,-0.09196128,0.024977764,-0.017789291,0.040350646,-0.024473155,0.03575133,0.0060154255,-0.016996339,0.027416084,0.008263786,0.014187822,0.064169124,-0.016120207,-0.08732152,-0.027895229,0.050884627,0.010442827,-0.043060664,0.020624574,0.030251013,-0.015373826,0.12035518,-0.029969612,-3.1906895e-34,0.006462521,0.05245307,0.0013132468,0.008836392,0.056397773,-0.00894827,-0.06989217,0.078103945,-0.107526876,0.023838542,-0.024739489,0.036878444,-0.0056580086,0.041267287,0.020905426,-0.0025097115,0.067858204,-0.06301002,0.043767624,-0.014150375,0.0809459,0.065058336,-0.051193677,0.030387808,0.0095438855,0.017912379,0.0151372,0.083835505,0.013807588,0.0010017409,-0.023995517,-0.056631625,-0.01452102,-0.012431043,0.06995488,-0.0262644,-0.06382193,0.008092436,-0.04040061,0.099966064,0.04712136,0.028505506,0.026523419,-0.00925139,0.04119695,-0.11439195,-0.07357357,0.05045697,-8.608704e-05,0.039451722,0.09369525,0.03712044,0.036997177,0.036136888,-0.036632888,0.05126133,0.045147043,0.05587387,0.014904841,0.0007004011,-0.04432595,0.009837454,-0.016320439,0.017396297,0.0140804285,-0.013853677,-0.13701813,-0.022672664,-0.003803757,0.05191579,-0.01563073,0.005315203,-0.023920247,0.04538808,0.07653397,-0.11356769,-0.07669922,0.008032409,0.069748856,-0.0014378572,0.012302373,-0.00527267,0.040356208,0.025936428,-0.05533954,-0.07330749,-0.078227475,0.06510481,-0.024010867,-0.019881424,0.06886532,-0.009024733,-0.053083945,0.020734461,0.045616034,-1.0161528e-33,0.07910625,-0.118279584,0.065209106,-0.053369977,-0.041429404,0.08255687,-0.04365602,0.010121517,0.046862565,-0.006915629,0.16520055,-0.014275302,-0.022631554,0.019033352,0.076036625,0.04224329,0.03385064,0.050443653,-0.07001713,-0.023255926,-0.09590752,0.036469683,0.01622312,-0.051607404,0.013579807,-0.009916997,0.039537206,0.010686296,-0.018075667,0.06178665,-0.030957863,-0.045109298,-0.062390268,-0.019402467,-0.078392506,0.05974811,-0.06118347,-0.03662741,0.011055485,0.056102455,0.042958103,0.045767587,0.054229435,0.05835547,0.0087007005,-0.016613077,-0.091051914,0.0354462,-0.034107342,-0.013627207,0.08622903,0.045840275,0.008030448,0.01976241,0.07115509,0.025634166,-0.025566775,-0.052372973,-0.04421026,-0.03640082,0.00086972816,-0.04750762,-0.049608372,-0.03787979,0.10366424,0.0315782,-0.074400924,0.122260675,0.044219337,0.029199108,0.03961008,0.04842262,-0.030582946,0.043634024,-0.033069745,-0.008529617,-0.0345268,0.0037574691,-0.0045518586,0.0044194832,-0.020972336,-0.048234142,0.00566287,-0.06659962,-0.043783724,-0.043486364,0.012636884,0.044635944,0.039963163,0.086443655,-0.012692228,-0.0017891276,-0.011841481,0.033278618,0.09114565,-2.8190362e-08,0.02505649,-0.1121721,0.008682318,-0.083041884,0.0031698276,0.0061031915,-0.018307695,-0.052040413,0.002935987,0.06703961,-0.043236036,0.11112488,-0.0068636667,0.0423007,-0.052976836,0.036493037,0.080212414,0.011583898,-0.000900408,0.007911762,-0.07724624,0.052397046,-0.077294946,0.036668427,-0.06558459,-0.039498005,-0.019017981,0.013347267,-0.03709575,0.012591492,-0.032855593,0.034970816,-0.03425347,-0.045317307,-0.07816392,-0.010805395,0.05467806,-0.064776555,-0.061776366,0.023271184,0.10170046,0.026146261,-0.063351825,-0.022552805,-0.038749095,-0.015432892,0.048357368,0.0085313525,0.001323854,-0.010981514,-0.0057072197,0.022999864,-0.03802492,-0.04641992,-0.07347183,-0.05346787,0.0137510905,-0.046790335,-0.023093162,-0.095110305,-0.003525308,-0.06260765,0.13982113,-0.00456029 +2.3.1.219,"A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well [1].",384,0.99999994,-0.06482587,-0.050532453,-0.124414906,-0.020366797,0.08139422,0.06750805,-0.1298923,-0.019916737,0.04253579,-0.03829441,0.008448018,-0.14832935,-0.053693872,-0.071911015,-0.06784284,-0.031939693,-0.05354685,0.05091362,0.025848288,-0.04130121,-0.023120664,0.007514469,-0.036824375,0.04842373,0.015650751,-0.0041654287,0.012041217,-0.07170529,0.036039826,-0.12685183,-0.0192864,0.049440313,0.070312046,0.016831204,-0.0015346773,0.1008631,-0.08529755,-0.00143297,0.0017469862,-0.019000217,0.05968191,-0.026796011,0.07038985,-0.015287577,-0.084687285,-0.0351013,0.043174207,0.001905906,0.046520136,-0.013135668,-0.03590049,-0.013672673,-0.04412608,0.062815756,0.019713288,-0.05701391,-0.039188653,-0.021939734,0.020594386,0.07086898,0.088849366,-0.027125256,-0.03721666,-0.014815753,-0.033167295,-0.022036964,0.00026037166,0.023299672,0.021385582,0.017286768,-0.05014176,0.04888039,-0.08306231,0.016187806,-0.02806034,0.13882798,0.02339862,-0.012205926,0.030325871,0.008649901,-0.01836579,0.12358594,0.065721944,0.028097741,0.05833566,0.060013555,0.00011844829,0.012126858,0.045835756,-0.01791978,0.020290133,0.06417927,-0.0009199614,-0.01906627,-0.052100413,0.021130688,0.0054353536,0.017729936,0.030994698,-0.03773968,-0.021707913,0.053584635,0.017167622,-0.025027288,-0.078016385,-0.0058072386,-0.055822797,0.04288562,0.04004041,0.0829388,-0.02533867,0.0003323176,0.0033998657,-0.020114403,0.035806056,0.037743345,-0.044004686,-0.11320957,-0.0015283308,0.011813259,0.025526209,-0.07420975,-0.03709638,0.03299924,-0.019457217,0.010551517,0.0022911495,3.729667e-33,0.035931177,0.13757989,0.030361438,0.04054974,0.041824687,-0.001878136,-0.068885036,0.02061251,-0.08280011,-0.030626714,-0.03519148,0.030674182,-0.069629475,0.10846116,0.036377043,-0.071451575,0.041452445,-0.022330126,0.006648731,-0.09936461,-0.0056571057,0.059994843,-0.090544604,0.009872069,0.019720232,0.00195632,0.041304857,-0.007134012,0.036619194,-0.059156988,0.011061941,-0.0032365317,0.01426232,0.031711914,0.023038687,-0.044780377,-0.025199538,0.0010334097,0.01889241,0.11605379,0.081902675,0.032322727,0.03954319,-0.011378139,0.08480866,-0.087060474,-0.09536294,0.04379313,-0.004342429,0.015420608,0.03473001,0.114340454,0.017814515,0.052332353,-0.012894516,-0.011697566,0.021019433,-0.015037504,-0.009475307,0.013276237,-0.06435952,0.03899557,-0.029422194,0.013058508,-0.048424363,0.016682772,-0.06264269,-0.020331793,0.041771915,0.0390412,-0.026046066,-0.03669524,-0.024129331,0.058193143,0.07516989,-0.052202612,-0.10016009,-0.02311884,0.039723333,0.018177532,-0.017074266,0.057168577,-0.039429072,0.026859738,-0.06579595,-0.103352115,-0.077771306,0.048862554,0.016799713,0.019696385,0.016118374,-0.026865076,-0.004831572,0.04927371,-0.009117702,-3.9513868e-33,0.09272317,-0.08712873,0.07949925,-0.048198543,-0.09077413,0.019265208,-0.048437595,-0.0036729279,0.018600613,-0.011597807,0.10453778,-0.033428412,0.06747868,0.0060642906,0.00791104,-0.027223501,0.069581345,0.12276251,-0.08755397,-0.049838025,-0.041414063,0.023562225,-0.0048826723,-0.008344251,0.0027063056,0.025777962,0.06800394,0.036700297,-0.026571294,0.0860185,-0.055677406,-0.070786245,0.010000031,0.07983515,-0.09417193,0.0027018602,-0.024382042,-0.01667428,-0.01993313,0.063157745,0.089389525,0.01578986,0.080015115,0.07378265,-0.009277622,-0.02937329,-0.031446703,0.061380275,-0.021579176,0.010664839,0.07544595,0.027959516,-0.019073809,0.008285586,0.07024926,0.012221379,0.0061107725,-0.058478225,-0.045142524,-0.04621307,-0.023089461,-0.029866721,0.020881027,-0.054802544,0.055438265,0.024966488,-0.060759697,0.14303376,0.0021103155,0.01862483,0.07525727,0.049272887,0.036206964,0.038376775,0.009023204,-0.055934116,-0.05371763,-0.0072207483,-0.038454544,-0.023295831,-0.034027256,-0.07051607,0.052380767,-0.08057525,-0.034780588,0.017202076,0.064253114,0.026449947,0.043535497,0.08206118,-0.03125895,0.030750746,0.017867252,0.121840104,0.071060136,-3.954156e-08,0.023122713,-0.06660191,0.019476356,-0.0886036,-0.03584284,0.050510354,0.0023583123,-0.04286195,-0.026627265,0.019175455,-0.04579693,0.08249602,0.01579686,0.0014327599,0.009304807,0.05041512,0.07327324,0.003937183,0.02187947,-0.014437016,-0.062386774,0.0772659,-0.053698324,0.0015748199,-0.08926151,-0.023131436,-0.0066136913,0.039252587,-0.013085049,0.03587608,0.02671937,0.0472028,-0.0072728535,-0.031698413,-0.005836559,-0.0469,0.031279307,-0.08604179,-0.02514557,0.001882581,0.058282286,0.06672728,-0.07858307,-0.023751585,-0.042498033,-0.018952543,0.008205082,-0.032552898,-0.038130734,-0.018355321,-0.0268693,0.00065601117,0.016066032,-0.098365165,-0.062543646,-0.016684238,-0.052802842,-0.008797173,-0.060994778,-0.05199489,-0.060899608,-0.058979914,0.12816644,0.020337973 +2.3.1.220,"Involved in the biosynthesis of plant xanthones. The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC 2.3.1.151, 2,3',4,6-tetrahydroxybenzophenone synthase).",384,1.0,-0.06439323,-0.041754123,-0.08175136,-0.06338589,0.017112803,0.07117023,-0.08486796,0.00831089,0.051716536,0.014053821,0.1305948,-0.09971009,-0.018554188,-0.07271629,-0.075736806,0.03795248,-0.021769764,0.061875843,-0.04566001,-0.018234981,0.026235327,0.0869271,0.05445726,-0.0052165976,0.067710176,0.03138436,-0.06970747,-0.017559601,0.054096222,-0.034798533,0.0060718576,0.05717326,0.08614481,-0.029083295,0.023453537,0.071339265,-0.031744193,-0.123115465,0.050299145,0.022084745,0.051861998,-0.08336353,-0.018265355,-0.029149365,-0.05477273,-0.09528856,-0.027472073,-0.020772772,-0.005774538,-0.024586482,-0.04722692,-0.029800765,-0.02354195,-0.00734787,-0.08838829,0.051196646,0.042720165,0.070684515,-0.047625326,0.07152229,0.040406246,0.06347703,-0.020865547,-0.00017564691,-0.040251948,-0.013665941,-0.08083355,-0.013512957,0.0010032684,-0.001680747,-0.060290713,-0.05190751,0.028261183,-0.0051181763,-0.049014002,0.06907565,0.06378809,0.013404726,-0.042590916,-0.04857227,0.02135207,0.020898987,-0.0014481914,0.06399224,0.013982801,-0.010069741,-0.025900006,0.03960681,-0.0028916898,0.03154594,0.076585,0.031617556,0.018233228,0.016212663,-0.054696646,0.10004438,0.079091564,-0.024785688,0.03804499,-0.04812413,0.018167406,0.014594766,-0.0006214961,-0.064287946,-0.012518222,-0.022064485,-0.058595657,0.048517473,-0.03630867,-0.082519025,-0.0494958,-0.06506196,-0.03161201,0.010241401,-0.050952446,0.042623043,0.07033838,-0.025982449,-0.05117524,0.02089028,0.0040678643,-0.057405543,-0.014338366,-0.0056827,0.002895002,0.03438318,-0.074877724,2.9771128e-33,0.10164423,0.14231111,-0.041010693,-0.072714925,0.027723385,-0.01771831,-0.034459837,0.07020202,-0.012700554,-0.026511237,-0.032267287,-0.03220767,-0.014065754,-0.04923231,0.018403813,-0.023059726,-0.022316713,-0.013755932,0.043420736,0.00041081104,0.024133349,-0.035363767,-0.08941909,0.02327833,-0.036480628,0.06217304,0.018701883,-0.06461902,0.0034678143,-0.01442633,-0.07375169,-0.066064544,-0.02355512,0.05867755,-0.027067589,0.06305343,-0.019532891,-0.0494784,-0.0053745955,0.065344885,0.042043556,0.045888063,0.053599395,-0.035421826,0.07045703,-0.0045368345,-0.085183136,0.03152507,0.10111253,0.036457993,0.060742807,-0.018880501,0.12119046,0.08660287,-0.0016075872,0.026775919,-0.07554445,0.060906578,-0.03719999,-0.0011290843,-0.03592446,-0.0068293256,0.0013638644,0.078680344,-0.0067676324,0.024270544,-0.09144865,-0.08110397,-0.05362462,0.037495147,-0.06599863,-0.08034918,0.060473293,0.03921445,0.058773592,-0.02257228,-0.054011703,-0.018023286,0.062282518,-0.018925672,0.041582137,0.068719566,0.027193222,0.015038573,-0.039232362,-0.007385976,-0.04673085,0.038077496,0.049760945,0.0500268,0.009377692,-0.08761594,-0.043301977,0.00053214066,-0.03345774,-2.8921979e-33,0.04436281,0.013622627,0.05519998,-0.011872575,-0.0046454608,0.044799764,-0.018746251,-0.028628977,0.0052385605,0.024373988,0.03835211,-0.003127106,0.043887142,-0.09272749,-0.049526982,0.02097904,0.08063579,0.06745758,0.0027684683,-0.029811557,-0.021045076,0.026532376,0.041475262,0.001857716,0.0018722863,-0.01762665,0.027706342,-0.0053049945,-1.7725666e-05,0.048792616,-0.035677318,-0.013917405,-0.039332643,-0.032227006,0.047215257,0.040991474,-0.080240816,0.058055747,0.0519009,0.080575645,-0.028592063,-0.0076580704,0.10036365,0.06706409,0.0553759,0.033683702,-0.039737385,-0.078486085,-0.033376966,0.015116535,0.051002305,0.013553271,-0.045303836,0.06524137,-0.022418424,0.017143372,0.0042474037,-0.020841641,-0.05849191,-0.016496252,-0.011176534,-0.025342226,-0.009374405,-0.033823952,0.051313117,0.039307807,-0.010399716,0.09009143,0.050433565,-0.024940755,0.13707198,-0.001273784,0.038652495,0.09031566,-0.06908794,0.01368901,-0.07207897,-0.11709891,-0.058345187,-0.076880336,0.06534266,0.06782971,0.05416138,-0.09755559,-0.069027446,0.01240061,0.041561488,0.10179811,-0.025176512,-0.013721579,-0.001554982,0.008199279,-0.031733267,0.06735128,0.13837719,-3.9013955e-08,-0.026392331,-0.043350916,0.041534342,-0.016984686,-0.0030572903,0.006933475,0.019233774,-0.011954729,0.09894099,0.01058625,-0.060069676,-0.013083656,-0.0011642945,0.06357223,-0.011640016,-0.03878651,0.03371912,0.0726472,-0.052777342,0.0010842214,-0.031184126,0.041458197,-0.025010167,-0.04924757,0.024911724,-0.12586218,0.0055971122,0.00045216415,0.060286976,0.009078527,-0.018141428,0.059212286,0.012389787,0.04098445,-0.06547449,-0.011116325,-0.017885089,-0.111577235,-0.016888453,-0.005249661,-0.003264654,-0.06250842,-0.06553331,0.036507208,0.035098676,-0.04749244,0.03667143,-0.007884644,0.048139118,-0.010596872,0.010037266,-0.0048138625,0.02120165,-0.15850885,-0.042577624,0.017849365,0.033399347,0.095840275,0.007246232,-0.06301012,-0.09336168,0.012047324,0.12645592,-0.054226402 +2.3.1.221,A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase [1].,384,1.0,0.0018102545,-0.021737408,-0.122473285,0.033157192,0.05722002,0.009995767,-0.07466849,0.031017711,-0.006307226,-0.064500354,0.0044233426,-0.09618828,-0.009734436,0.026903247,-0.112647966,0.0055407123,-0.001100192,0.021307435,0.016980512,-0.07081193,0.021166269,0.03937067,-0.018090917,-0.025088351,-0.010748243,-0.044560168,0.05688841,-0.030730681,-0.057412114,-0.07463715,-0.025418503,-0.03910434,0.0031856583,-0.072718844,0.030385539,0.083282776,-0.009368353,-0.018491022,0.0832862,0.015816055,0.021532984,-0.04920721,0.027808849,-0.039985023,-0.061134744,-0.003926493,-0.07585067,0.02319242,0.066495664,-0.013911547,-0.0724718,0.015371375,0.0094113825,0.02253485,0.07683923,0.047359932,-0.023863439,-0.043733746,-0.024607189,-0.0047788327,-0.014710782,0.018309474,0.013559976,-0.0009456682,0.0048845224,-0.044369146,-0.0043582222,-0.0033398247,-0.073447935,-0.010253205,-0.061846375,-0.01969553,-0.015910309,0.002398499,0.11559994,0.073052496,-0.06440743,-0.008875237,0.09150643,0.0055345027,0.06514919,0.02207242,0.100572415,0.058884073,0.019365141,0.014332768,0.00045848507,0.03001813,-0.011508851,0.08646766,0.029703572,-0.00906334,0.011364795,0.046209056,0.0024047808,0.04729019,0.04939729,0.060211178,-0.019779773,-0.05159609,-0.045034733,-0.03954762,0.00054739433,-0.027588302,0.018349143,-0.054986555,-0.020541802,0.06994869,0.054946445,-0.006938221,-0.0021734962,-0.025429647,-0.042487882,-0.13035019,0.061329257,0.0057694693,-0.019213356,-0.060749628,0.006746837,-0.040110964,-0.010594922,0.022508759,-0.06289256,0.0430725,0.06718348,-0.054466926,-0.09004971,1.8589925e-33,0.03923804,0.115345515,-0.053029753,0.017590806,0.028387452,-0.07150242,-0.0107429605,-0.015976112,-0.02596886,0.013668579,-0.051006004,-0.012311303,-0.08808783,0.041262172,0.059682094,-0.05404915,0.014109727,-0.0388975,0.050761305,-0.032728247,-0.0094564585,0.056622803,-0.030670602,0.007736189,0.03266208,0.06553569,-0.033843637,-0.046625543,-0.01584321,-0.002581898,-0.045376286,0.018243488,-0.11924213,0.046112496,0.051115233,0.02414964,0.030807672,-0.039888337,-0.11140674,0.026913568,0.007194764,0.021538444,-0.042412724,-0.107526205,0.025798185,0.002896078,-0.12476108,0.07159523,0.07562144,0.022446958,0.09337852,0.058047265,0.09774103,-0.008640904,-0.00017106537,-0.009394717,-0.101105906,-0.038619433,0.013763307,0.010689737,0.0011680358,-0.034438998,-0.04790347,0.07114439,-0.05181599,0.009183397,0.052469924,-0.08600997,0.07306408,0.03030719,0.009400154,-0.023399485,-0.009658336,0.03947287,0.017621936,-0.003747765,-0.100329846,0.0110024605,0.0002875643,-0.00028038453,0.060158566,-0.021674037,-0.012138702,-0.027481904,-0.039315384,-0.0074369544,-0.008135032,0.044087604,0.034097098,0.00616784,0.00939379,-0.027798656,0.027690703,0.099852555,0.02889255,-3.5771053e-33,0.10784344,-0.10988928,0.025786093,-0.055921484,-0.14838293,0.060507454,0.01982134,0.0017918161,0.04317602,0.002551854,0.04525285,-0.026029063,-0.0009353864,-0.026674569,-0.023369376,0.012268789,-0.0071181,0.060233474,0.057414148,-0.03613255,-0.05051525,0.028472848,-0.0768561,0.09517236,0.011229529,0.08113265,-0.02842166,0.09029245,-0.005268861,0.0073032547,-0.01548393,0.0088977935,0.031992294,0.015084137,-0.08514837,0.06604024,-0.019151757,0.0488953,0.002430779,0.07678106,0.027728342,0.002566183,-0.027449666,0.05887722,0.03388271,0.032952588,-0.018143812,0.011864485,0.096333936,-0.11109822,0.014739786,0.028869348,0.006523278,-0.05817113,-0.028049534,0.057835687,0.06761428,0.00271205,0.05858256,-0.1082997,-0.06358774,-0.012054221,0.017845545,0.03527144,0.018792752,0.10076144,-0.04818873,-0.047462285,0.016135857,0.010148024,0.02169507,0.020891326,0.008115032,0.03506503,-0.03209523,-0.047810066,0.008351648,0.0022024955,-0.015831875,0.045941237,0.0388902,-0.034125805,0.05803216,-0.0148218265,-0.05302232,-0.06593263,0.0847534,0.048204042,-0.063296676,0.0064318096,0.04702246,0.08279732,-0.030521631,0.026586043,0.03323652,-3.2472382e-08,0.027478687,0.019743456,-0.029215604,-0.074170634,-0.0027463513,0.05517609,0.0049226927,-0.06435308,0.034409966,-0.034982067,-0.1307085,0.09808311,-0.0062588295,0.07885618,0.03177456,-0.037615325,-0.019223372,0.012215519,0.026145177,-0.04694908,-0.117846705,0.05656534,-0.0485565,-0.0476273,-0.03469396,-0.0335908,0.034698766,-0.022848697,0.1310073,0.1240479,-0.07611845,0.06871813,0.01907269,-0.08357901,-0.02166921,0.009411028,0.0042309267,-0.12785895,0.012375216,-0.04965497,-0.010693082,-0.021209383,-0.019460006,-0.055759963,-0.0030108036,-0.044015363,-0.008396064,-0.04061448,-0.0012666265,-0.022829881,0.067742266,0.04193969,0.020713262,-0.068968154,-0.019175865,0.028336544,-0.009063432,-0.0352056,-0.053546578,-0.08333163,-0.08678544,-0.021709774,0.17330532,-0.0097929165 +2.3.1.222,"Part of the degradation pathway for propane-1,2-diol . ",384,1.0,-0.003214863,0.002930313,-0.017759712,0.010530915,0.16976638,-0.08555367,-0.011548532,0.048076864,0.058462635,-0.017435493,-0.05712463,0.0644785,-0.05763972,0.00834437,0.047872074,-0.0052655833,-0.062752664,-0.057012513,-0.01678071,-0.020965122,0.011637547,0.00762412,-0.022371693,0.04072317,-0.040995233,0.049468808,-0.0024839814,0.073855914,0.052864276,-0.022909658,0.032854453,0.015075071,-0.068827294,0.0010467485,0.024018679,0.04998363,-0.038648225,0.04919707,0.03898038,0.0027765753,-0.0032243144,0.014582652,-0.0082469825,-0.023809936,-0.0073102387,-0.009359197,-0.07884715,0.077773795,-0.03796416,-0.03771826,0.02897897,-0.004526676,0.011740299,0.012575461,0.07502856,0.008833875,-0.047533937,0.0853776,-0.040985078,-0.005542941,0.036830712,0.07093382,-0.10537999,0.013039259,-0.09823464,-0.030928392,0.09457289,-0.09165993,0.05946428,0.011994086,-0.1340674,-0.0581568,0.041420847,-0.077643834,0.017509261,0.042240262,0.0329333,-0.044000726,0.03715029,-0.08517336,0.058057513,0.027766705,0.033305716,-0.06946494,-0.008826718,0.0406821,5.4781678e-05,-0.098459914,0.026455252,-0.056759246,-0.010623569,0.06792073,0.06316744,0.023106905,0.03253326,0.107611604,0.03841584,0.058650695,0.040581595,-0.0002751666,-0.058500443,0.07731418,-0.09399225,-0.098346,-0.07081788,0.03546581,0.047987867,0.08411422,0.009315975,0.010542365,0.02104048,-0.030074406,0.09620353,0.0303154,-0.010316182,-0.07026825,-0.02097991,0.034710873,-0.0051605995,-0.023646181,0.005969097,-0.0010899826,-0.017456157,-0.018222542,-0.067696325,0.006853127,0.031943407,-3.5451576e-33,-0.027110232,-0.008134782,-0.059475977,-0.0034821092,0.016419725,-0.0035342756,-0.059682947,-0.02748433,-0.026312359,0.0050808876,0.06992374,-0.043462995,-0.10687709,0.022875,-0.054207046,-0.050397556,0.04461065,0.07356166,0.04191123,-0.03912242,-0.06429846,0.080089636,-0.020844445,-0.009784887,0.063990206,0.024756365,0.044134375,0.010203275,-0.013800251,-0.04181553,0.05372846,-0.040793,-0.11368839,0.027418882,-0.033960864,-0.041204326,-0.027312849,0.022668831,-0.03368392,0.010592851,-0.00820557,0.059805732,-0.014919814,0.024180127,-0.03817296,-0.041923378,-0.009746704,0.11890166,-0.057845403,-0.058611333,-0.036206767,0.019230593,-0.00023918868,-0.050035346,-0.07802965,-0.00033560256,0.069418184,-0.06643631,0.057579547,-0.051926903,-0.039472163,0.09488331,-0.07466916,0.006810079,0.07668882,-0.056107175,-0.048150145,0.046663936,0.08482363,0.012236217,-0.060071673,0.014582729,0.014233441,-0.06311558,0.066175826,-0.004891326,-0.011270809,0.0403795,0.05267461,-0.011738653,-0.04529244,0.0014331032,-0.010657613,0.041757178,-0.050081816,-0.021646505,0.018614056,-0.06630902,0.033902865,0.06257783,0.0001418862,-0.05873561,0.03781395,0.055047248,0.096213154,1.6924206e-33,-0.021269588,0.035765,0.027725177,-0.017716777,-0.057577293,-0.0042206235,-0.029298661,-0.038939074,0.03948534,-0.05229067,0.055045627,0.014263961,-0.020549254,-0.03569306,-0.026775118,0.017573707,-0.022255952,0.02085123,-0.015650846,-0.005200023,0.023003362,0.05822934,-0.049503695,0.049784686,-0.021380102,-7.5881566e-05,0.052188292,0.015721207,0.06418369,0.05714347,0.060532212,0.09373419,0.011116027,0.0028109923,-0.05356126,0.025326736,-0.08145587,-0.0021720934,-0.018634265,-0.019595245,0.006456059,-0.0075399503,0.01761494,-0.08128563,-0.024228225,0.045794196,0.06923876,-0.03298232,0.028379852,0.007998522,0.032789454,-0.0005783459,-0.1049917,0.043830555,0.05354041,0.056702204,0.013755581,0.045370787,-0.0028611615,-0.036642794,0.027797837,0.025587164,0.037797503,0.114440404,0.04857666,-0.0076741977,-0.029157564,0.065817036,0.10307186,0.021028869,0.10151271,0.08341363,0.07260467,0.016516024,-0.05980977,-0.060264662,-0.036428224,-0.022469036,-0.039676014,0.022083588,-0.00421327,-0.041552655,-0.059828576,-0.09288468,0.0008819017,-0.14895412,-0.013157246,0.036463343,0.038451202,0.03968448,0.054626323,-0.066104114,-0.08448527,0.05504759,0.0055143964,-2.1264306e-08,-0.05630211,0.013916729,0.029167289,-0.0021900947,-0.059331,-0.014194653,0.13802905,0.15238796,0.003273941,-0.026349055,-0.033702835,0.016455872,0.060730357,-0.08218432,0.036765717,0.0424076,-0.029467775,-0.021860825,0.02325275,-0.04304446,0.0046624863,-0.11301282,-0.026770964,-0.04441505,0.0086775785,-0.11368292,0.041903827,-0.021287514,-0.0055078394,-0.011589801,0.013074109,0.0639279,0.01688625,-0.09179379,0.07490623,0.004122123,-0.008258359,-0.024177225,-0.02083039,0.074703254,-0.033978235,-0.00720168,-0.055580646,-0.030062124,0.0162282,-0.045362476,0.013774244,0.076126195,-0.06064268,-0.010310604,0.04894481,-0.027559051,0.023602894,-0.055835914,-0.046495147,-0.053626977,-0.020077135,0.12084575,0.024206528,-0.060566846,-0.01616957,0.052712165,0.10186153,-0.09739046 +2.4.1.294,Isolated from the plant Daucus carota (Afghan cultivar carrot).,384,0.99999994,-0.10611517,0.03214496,-0.13874198,0.033715565,0.03667283,0.018587496,-0.022932997,0.017101204,0.059042968,-0.058570884,0.12904789,-0.06183736,-0.042325094,-0.04818809,-0.017097138,0.012194255,0.06948857,0.0018453089,-0.020705294,-0.06222069,0.015696567,0.093558386,0.023180028,-0.0067908447,0.017235186,-0.05933787,-0.04637157,0.026812261,-0.0011270327,-0.056279346,-0.044654526,-0.028618218,0.027956031,0.017173989,0.04762938,0.015843667,-0.0048218295,-0.0045210854,0.09213318,0.011887376,0.014092401,-0.031954903,0.03153197,-0.025433773,0.03575745,0.0061106593,-0.16198151,0.044135477,0.032146577,-0.061969094,0.01954279,0.014172816,-0.0316628,0.0077327546,0.00810349,-0.024822116,0.03006495,0.043480292,0.029051958,0.10311582,0.06537199,0.04308405,-0.00377111,0.010000371,-0.09465592,-0.0025934235,-0.044830937,0.0036147516,0.124438226,-0.025120676,0.040543098,-0.038435653,0.030974742,0.022728793,-0.053464774,-0.049114466,-0.031971723,0.05309321,0.018975604,0.021588866,0.049497385,0.07783991,0.04899246,0.034544047,-0.014595472,0.033006664,-0.027573043,0.026195638,-0.07266438,-0.025622798,-0.0054206755,0.0318741,-0.034453444,0.021009553,-0.016095718,-0.04784583,0.14771557,-0.042432316,-0.030525902,0.045207966,0.024845952,0.002265074,0.026048625,-0.11749506,-0.08363718,0.046354305,-0.040653635,-0.08608241,0.043249812,0.0067168125,-0.052409235,0.0542307,-0.081016414,-0.09644604,-0.045244593,-0.046567794,0.016018339,-0.044902667,-0.002548805,0.0040692636,-0.01642457,-0.023338625,0.07725049,0.03400804,0.045628563,-0.018570941,-0.022628974,-4.2589327e-34,0.040796444,-0.042163856,0.014225804,-0.064675465,0.021559574,-0.04259797,0.02138487,0.009735882,-0.029920714,0.0456143,-0.04998526,-0.11194892,-0.07801676,-0.008079869,0.009771208,-0.008490482,-0.02830896,-0.0255096,0.07464555,-0.051534303,-0.023216365,0.05842224,-0.028050767,0.00846212,-0.026534488,-0.023478027,-0.0484186,-0.09425018,0.07950245,0.018514993,0.050813545,-0.07527568,-0.026393903,-0.009690593,-0.06179295,-0.0062435805,-0.12459687,-0.0809211,0.023764767,0.045935072,0.10455927,0.011448504,0.07419704,-0.017207753,0.04155452,0.056074344,0.008631092,0.057963308,0.037319057,-0.021828748,-0.0015163646,-0.028956698,0.02472541,0.041278366,-0.060878176,0.042270858,-0.005822378,-0.00082927407,-0.03228561,0.054473758,-0.007547449,0.04833602,-0.056793373,-0.00056381186,0.00014131292,-0.0014665573,-0.17431995,-0.0070304326,-0.0017390415,-0.0070627397,0.02189555,-0.061173286,0.01211467,-0.08632047,-0.014006133,-0.0047523146,0.041334476,0.07310625,-0.047036212,-0.0016609784,-0.0077020996,0.045157954,0.029208846,0.001653654,-0.023767387,0.049142182,-0.06151562,-0.04295477,-0.001804773,0.08027827,-0.04350538,-0.00088411325,-0.06751172,-0.057988256,0.071039565,-1.2522755e-33,0.04384258,0.039079074,0.01829831,0.0014503032,0.033049203,0.07323777,-0.06584836,0.037450567,0.048850626,0.015905313,-0.08402374,0.05478171,0.041478742,-0.054401815,0.030601995,0.12793991,-0.0025830083,0.15606014,-0.038723156,-0.022152968,-0.103568874,-0.0064930418,0.0325024,-0.06335322,0.041751698,-0.0064936792,0.010005737,0.013180993,0.06067369,0.004724039,0.06964428,-0.014650005,-0.0690866,0.04517312,-0.06806004,-0.008807251,-0.063162304,-0.092066,-0.028423162,0.074035026,-0.058731437,0.029164711,-0.004912588,0.048946053,0.094051376,0.04195008,0.030706502,0.045911107,-0.028650569,0.025475916,0.08734113,-0.0036103767,-0.0042233053,-0.006714784,0.03926006,0.0049237194,0.075095996,0.06272465,-0.0512554,-0.060301468,0.058579322,0.0033230819,-0.057910398,0.025931615,0.049485147,0.06907432,0.04484176,0.04473214,-0.019790333,-0.001038695,0.033963174,0.052737467,-0.017265622,-0.026078269,0.010983033,0.0462939,-0.022496108,-0.004289198,-0.017739287,-0.0152270235,0.004195458,-0.027755726,0.042939514,-0.04306898,-0.021940209,0.012837744,0.02282561,0.013648233,0.0374285,0.06605037,-0.055781353,0.043422762,-0.092042446,0.01928362,0.074546516,-1.858852e-08,0.109276,-0.011074374,-0.037042223,-0.07681127,-0.04413926,-0.031182447,0.005772394,0.022528965,-0.037160862,0.013134829,-0.055157065,0.017057618,-0.053133193,-0.002110459,-0.023245657,-0.058769003,0.08151198,0.04793794,-0.016860252,0.032818995,-0.09158104,0.03167704,-0.020673234,-0.030071408,-0.0674731,-0.032594886,0.07402355,0.0041871425,0.11461636,0.05889794,0.06168166,0.0489603,-0.074747406,-0.12115394,0.037560742,0.018080078,-0.07372041,-0.0057682246,-0.01492411,-0.031247916,-0.044318415,-0.020936323,0.019539969,0.029889263,-0.09256133,-0.005484109,-0.0060821977,0.014326123,-0.030947203,-0.0137995,-0.02512752,-0.017340932,-0.023991989,-0.030919136,-0.075225435,0.00041258094,0.043729436,-0.0383905,0.010460504,-0.019303631,-0.12320455,0.017673131,0.11667222,0.11083546 +2.4.1.295,Isolated from the plant Matthiola incana (stock). No activity with anthocyanidin 3-O-glucosides.,384,1.0,-0.014031471,-0.049542185,-0.14893648,0.07145173,0.013785537,0.002322422,0.02415044,0.0041356627,0.059764773,-0.008536457,0.10421366,-0.043802023,-0.08577038,0.027081216,-0.05628251,-0.018941956,-0.016470768,0.013792198,-0.042827815,0.0029726895,-0.030071853,0.020256136,-0.0024986023,0.035560124,-0.020589283,5.9311013e-05,-0.0939044,-0.022923583,-0.0027067668,-0.029874267,-0.074174345,-0.03214692,0.09718129,-0.012809707,0.022662181,0.057851687,-0.06247571,-0.038642235,0.021912076,-0.0021039152,0.034811534,0.041291445,0.06630716,-0.005668612,-0.042691663,-0.009857336,-0.0972956,-0.0074898116,0.095050134,-0.0027615726,-0.020709386,0.001407928,-0.050968412,0.05975092,0.009964134,-0.06427068,-0.0006802717,-0.046755668,-0.004994304,0.118103586,0.041528538,0.037453126,-0.022639945,-0.024434285,-0.0563255,-0.015892452,-0.066040106,0.006215409,0.08185038,-0.009601426,0.03969338,-0.03204743,0.08333661,-0.0173863,-0.09194131,0.12107771,0.0056007677,0.0104211895,0.037232254,-0.033386655,0.07538042,-0.0061226706,0.07360828,0.0997118,-0.020803632,0.014852148,-0.010748181,0.08041899,0.020944381,-0.004585208,0.060933262,0.09286047,-0.010042232,-0.015568319,-0.01799742,0.0010297364,0.087509975,-0.03317356,-0.12722898,0.018533379,0.015287882,-0.00061004417,0.06449168,-0.12917124,-0.10627295,0.028050175,-0.07641254,-0.07677243,0.055096187,0.0007303177,-0.04597865,0.028569523,-0.10164192,-0.030665532,-0.04703308,0.02110721,0.06799741,0.0063818498,-0.06509056,0.007862425,-0.08298114,-0.0037739563,0.064327195,-0.036483336,0.011434748,-0.03785357,0.0035245412,7.396809e-34,0.04109273,0.0013355862,-0.007367535,-0.05895137,0.064734004,-0.049016323,0.041296188,-0.032445222,0.032571364,-0.0332988,-0.039874684,-0.05044474,-0.025199624,-0.010489484,-0.016646162,0.042935938,-0.013062066,-0.14033714,0.12070938,-0.035349473,0.067409344,0.044858593,-0.07172578,0.03948847,0.010840331,-0.010449145,-0.052566618,-0.043941583,-0.026466802,0.019231403,0.015160773,-0.043711532,-0.11001659,0.012510336,0.031044606,0.025612727,-0.096230835,-0.066083856,-0.033747073,0.063824266,0.04901817,-0.0075548408,0.11264162,-0.016634546,0.064492404,-0.002318636,-0.08459269,0.10579874,0.07644456,0.094559625,-0.019559147,-0.040541016,0.034955274,-0.008244538,-0.077521436,-0.043994922,-0.039464038,-0.015543241,0.035044156,0.061683558,0.04610691,-0.010774946,-0.041787297,-0.04110878,-0.045251355,0.065912925,-0.13184196,-0.018113524,-0.029474942,-0.03231211,0.031223554,-0.07445516,0.025777716,0.014398041,0.014312622,0.008824465,-0.044061843,0.03231625,-0.03992681,0.03873337,-0.0007854278,0.004712753,0.09055064,0.117862724,-0.07154723,0.07320668,0.026140025,0.12830828,-0.012034698,0.048908945,0.07893893,0.056458607,-0.061390772,0.025541293,0.05246098,-1.3491904e-33,0.08301609,-0.0003590357,0.037939016,-0.10265548,-0.0479786,0.049157992,-0.043368664,0.04393408,0.026931288,-0.03775019,0.01643498,0.044680037,0.044320922,-0.041290697,-0.05406841,0.049658045,0.033972777,0.08510442,-0.0030215476,0.032682527,-0.07940161,0.013815869,-0.037175987,-0.025788661,0.0871303,-0.049601667,0.08495503,-0.02620589,-0.034338363,0.00029727607,0.012126111,0.055265147,-0.056692686,-0.043420915,-0.010621815,-0.006411405,-0.024649294,-0.088193044,-0.050874405,0.017938167,-0.028214661,0.048475716,0.015784819,0.10301849,0.058698367,0.06915387,-0.017474202,0.023533273,-0.064703606,0.052989464,0.038032163,-0.06265301,0.00089723885,-0.0031933081,0.036191754,0.007643052,0.06748813,0.0019646867,-0.061160218,-0.025529746,0.01210192,-0.00909604,-0.057974745,-0.025221944,0.04110969,0.1030125,0.024921512,0.019468356,-0.001745021,-0.012893834,0.039859366,-0.012095135,0.043834165,0.021977708,-0.048214987,0.04815324,0.019089915,-0.035063524,-0.008685972,-0.033807576,0.080730714,0.02837088,0.04346919,-0.03940595,-0.016835237,0.034336682,0.007384271,0.020516874,-0.03298126,0.039734073,-0.050231434,0.07254881,-0.049032692,0.05431643,0.09512479,-2.5147255e-08,0.015613936,-0.019450556,-0.024203122,-0.041616455,-0.027234491,0.03360774,0.030656708,0.060262304,0.006710207,0.051468898,-0.021050354,0.03128871,-0.004637697,0.03919486,-0.043495487,-0.017094113,0.09372202,0.016433356,0.0031331673,-0.03721276,-0.13848019,0.002941141,0.0032005806,-0.05634277,-0.05606519,-0.05344328,0.06490688,-0.023706028,0.008013956,-0.009410806,-0.013511595,-0.01624354,-0.026500119,-0.07536834,0.009848073,0.023968048,0.0077550667,-0.09632007,-0.017903559,-0.05313078,0.00053912826,0.021026168,0.013846594,-0.010137304,0.027257979,-0.03706224,-0.0043043513,-0.02047696,0.044233747,-0.020652251,0.069428794,1.0470014e-05,0.037470132,-0.062335253,-0.042969123,-0.0368264,0.015852256,-0.038593136,-0.010998803,-0.012631978,-0.094467625,-0.09244356,0.06540933,0.054113876 +2.4.1.296,Isolated from the plant Petunia hybrida. It does not act on an anthocyanidin 3-O-rutinoside,384,0.99999994,-0.025976915,-0.0038683794,-0.15429801,-0.0003311987,0.056129016,0.048017014,-0.0030196728,-0.010943883,0.05240407,-0.041257713,0.10047759,-0.025043134,-0.09136038,0.017828679,-0.03426973,-0.0015677878,-0.026418185,0.047107827,-0.039938938,0.06438205,-0.03352833,-0.04955171,0.050246187,0.008294845,-0.039011512,0.02705464,0.0008338485,0.00015418643,0.015350538,-0.10157527,-0.04837243,0.010225986,0.045257334,-0.078235775,0.03727782,0.033428118,-0.043552104,-0.022273498,0.05724315,0.057410292,0.020082584,-0.013032895,-0.0070443093,-0.07207669,-0.044831343,0.017295714,-0.10441121,-0.037908647,0.09869351,-0.05920882,-0.02319084,0.0075517446,-0.069678895,0.07069704,-0.015802955,-0.059315503,-0.045793865,0.04259335,0.02132824,0.101759195,0.060227036,0.055970374,0.0049579083,-0.0005452999,-0.008284929,-0.05675999,-0.0798794,-0.0069830944,0.087273896,-0.03918068,0.06317073,-0.07090385,0.02564986,-0.008130989,-0.03750757,0.074638166,0.004499678,0.05190899,0.03581389,-0.032060888,-0.030669454,-0.02547305,-0.024765294,0.08211695,0.02444406,0.04789629,-0.030286405,0.028258229,0.0008122971,0.050496653,-0.0024092663,0.0984762,0.020792488,-0.027921766,-0.013496121,-0.0066360724,0.048477046,-0.013271498,-0.006694079,0.03245501,-0.010414703,0.04205983,0.01823321,-0.09969294,-0.08544331,-0.021779105,-0.08053235,-0.097521394,0.057254035,0.012648188,-0.06482273,-5.8894006e-05,-0.02813807,-0.0629502,-0.048312556,0.01900146,0.018134613,-0.075639375,0.0141797885,0.01630549,-0.06335454,-0.04098954,0.027925393,0.045795225,0.04325488,0.0039924555,-0.05072005,2.0259478e-34,0.07708816,-0.038128905,-0.031641513,-0.052345347,-0.0047727143,0.018937347,-0.0029195545,-0.019576633,-0.07192408,0.0010025142,-0.07492449,-0.027017718,0.006017667,-0.046692476,-0.020275462,0.01175717,0.029354608,-0.09837863,0.040559523,-0.02005827,0.07105238,0.08616092,-0.08617912,-0.013668696,-0.021580003,-0.008123663,0.0019299639,-0.07124945,0.022567905,0.027047588,0.03559082,-0.08416236,-0.06748471,0.07864509,-0.008604457,0.014472403,-0.120534346,-0.08784648,-0.055391196,0.071499564,0.07502332,-0.01014606,0.07643785,0.019643944,0.053851854,0.0011785313,-0.0660593,0.0517432,0.119933575,0.026162231,0.020577664,-0.0107840765,0.04368354,0.0028190487,-0.0756743,-0.03771,-0.03400881,0.0035020732,0.015813664,0.04887455,0.017151952,0.023415899,-0.02829373,-0.011413026,0.056834225,0.033715006,-0.17493926,-0.010587025,-0.013345165,-0.054696262,0.005632837,-0.119120106,0.047910612,0.00034312817,0.04182771,0.001911415,-0.026074503,0.0735448,-0.0012883081,0.026338078,-0.04499113,0.044329736,0.059694797,0.07179289,-0.085230365,0.048375126,0.042987976,0.049566083,-0.054390598,0.039141383,0.11660937,0.0029946936,-0.024954189,-0.014388164,0.059929118,-1.7748122e-33,0.07014817,-0.0014699869,0.04591605,-0.096322745,-0.054842923,0.074416794,-0.062035967,0.01954369,-0.06488539,0.065031365,0.037436217,-0.016459469,0.08395147,0.016941002,-0.053063683,0.075024135,0.06303327,0.06944441,-0.010875599,0.013952167,-0.12067608,0.07121902,-0.008308455,0.009396805,-0.031452503,-0.03399256,0.080258384,-0.024837852,-0.03996849,-0.029697897,-0.0016212079,0.017389005,-0.13603401,0.00012782204,-0.024119688,0.0015553563,-0.06859951,-0.111870825,-0.061287954,-0.007588759,-0.061737627,-0.02179656,-0.030288732,0.09536785,0.07199885,0.014666613,0.020295985,0.030681878,-0.08042041,0.08609623,0.042319063,-0.02144916,0.051026043,-0.011986886,0.037744902,0.030765435,0.05665228,-0.019622885,-0.06173956,-0.016348213,0.115991406,-0.03691222,-0.030665977,0.052103758,-0.007514542,0.13303068,0.012889119,0.038341697,0.025064943,-0.021467147,0.055405617,0.077263094,0.060576357,0.027676098,-0.015080515,0.02352177,0.040924065,-0.06533301,-0.017688213,-0.04503486,0.0015931939,-0.043006126,0.0059703756,-0.07189104,0.03940809,-0.027177066,-0.0273452,0.012344717,-0.0034523387,0.025547616,0.0020762302,0.040445045,-0.050290003,0.061112728,0.118093535,-2.4076986e-08,0.021102417,-0.0104995435,-0.0069046407,-0.029300967,0.038186338,-0.01697029,-0.0072830413,-0.045828227,-0.03190864,0.02979565,-0.025457688,-0.01517792,0.006030183,-0.016753182,0.09334974,0.036684927,0.120815426,0.060971387,-0.011491768,0.024041492,-0.091171175,0.022883922,-0.045220707,-0.038276084,-0.027381748,-0.015212787,0.08582787,0.00030464213,-0.0014615394,-0.033701025,0.07747273,0.010788768,-0.05248374,-0.063881576,-0.004435477,0.031345475,0.038069364,-0.012829112,-0.038021512,-0.05560761,0.015638549,0.0007885114,-0.045071367,0.031204386,-0.025359767,0.01088297,-0.043579508,-0.04070466,-0.0032628174,0.011115217,0.06669502,0.019194791,0.06447775,-0.07892729,-0.069567025,-0.012762568,0.002652015,-0.020213157,-0.020001458,0.03139526,-0.07364676,-0.019002736,0.059653625,0.06951474 +2.4.1.297,Isolated from Ipomoea nil (Japanese morning glory).,384,1.0,-0.046937134,0.08919682,-0.03016601,0.047490448,0.022481963,-0.011744351,0.06210208,-0.024336388,0.042188898,-0.05450108,0.09082592,-0.06866786,-0.059261236,0.08398014,0.036628895,0.027215073,0.02828664,-0.0491357,-0.004984756,0.0105284415,0.0064303107,0.07359653,0.021914741,0.00300667,-0.020782247,0.076227024,0.030710934,0.036152154,0.02176306,-0.15584236,-0.060758807,0.02020045,0.051968496,-0.095500834,0.030150076,0.031849302,0.010324542,0.001159587,0.0066372794,0.043291792,0.034191273,-0.022170397,0.06433353,-0.051828336,-0.017632341,0.07434512,-0.054308765,-0.010414326,0.076176554,-0.022028247,-0.026604509,-0.101122305,0.0303869,0.0634612,0.052436206,-0.07283214,-0.048057515,-0.10459648,0.00021002004,0.10186512,0.05303121,0.051583882,-0.03262249,0.010841043,0.034325056,-0.04208733,-0.07836276,0.030253198,0.07471702,-0.090268366,0.029378159,0.012516068,0.07112334,0.030408043,-0.13261019,0.041887317,0.03649489,-0.04869314,0.029938575,0.035098426,-0.015049029,0.061818477,0.053667307,0.040132556,0.031583793,0.0608365,0.026446886,0.058667112,-0.06897895,0.02482545,-0.026861005,0.089275286,-0.014384562,-0.017523492,0.010578327,-0.035382558,-0.048565157,0.00053918007,-0.092832044,0.07746364,0.054914344,0.0045742583,-0.0062168674,-0.069037445,-0.12203849,0.0063467547,-0.06904764,-0.05550326,0.059222914,0.031435534,-0.07353709,-0.04297956,-0.059476443,0.037228048,-0.01609377,0.02232726,0.04890555,0.03586659,-0.016968966,0.014633155,-0.06906546,-0.07079935,0.077430435,-0.039988942,-0.016117672,0.059292093,-0.028743096,-5.0600527e-34,0.079471536,-0.006720713,0.0035283347,-0.02097165,0.03428346,-0.043413974,-0.01840137,-0.019038748,-0.0882101,-0.005222212,-0.065154605,-0.031482812,-0.073762484,-0.038984917,0.046175666,0.011037218,0.033119977,0.01417081,0.034297477,-0.006009518,0.045183837,0.12261062,-0.036968097,-0.019363983,-0.060990714,0.024988968,0.010850761,-0.08729365,-0.0026839992,0.045063123,0.09957748,-0.06059303,-0.0032937513,0.015403135,0.02621915,0.020127552,-0.027923573,-0.057616692,-0.060032308,0.016904877,-0.029151876,-0.0050762375,-0.007164147,0.023957502,-0.015786834,0.018620722,-0.048511926,0.015012902,0.08050034,-0.036109492,-0.05523557,0.05822422,-0.024705911,-0.031692617,-0.06649931,0.05045209,0.02555245,0.033774346,0.03330385,0.029274281,-0.008472791,0.080971956,-0.076114625,-0.04064373,0.051153217,0.03283337,-0.050883994,-0.066298835,-0.05099045,-0.03402494,0.04107919,-0.06122891,0.03583383,-0.029134266,-0.023551546,-0.09670992,0.0070675877,-0.008942735,0.010665552,0.000734582,0.020773718,0.05682632,0.028523803,0.033624213,-0.084631115,0.04082376,0.030139344,0.0521426,-0.006234579,0.0355604,0.042487815,0.017710656,-0.040358532,-0.08541194,-0.051271304,1.0635957e-33,0.113802575,-0.056422226,-0.059396774,-0.047864642,-0.0038455776,0.07266156,-0.027754132,0.08669708,-0.06437061,0.046165146,0.00344281,0.04207771,0.123546205,0.029374178,0.0087655075,-0.0013552727,0.07294326,0.1251454,-0.04379295,0.009302573,-0.0786385,0.04351979,0.0150871,-0.036563534,-0.016522173,0.08144358,0.06791729,0.076152585,-0.03922257,-0.020132136,0.014478357,0.0063633793,-0.10129099,-0.09048756,-0.030532423,-0.008124474,-0.10071241,-0.093082465,-0.027670005,-0.019924793,-0.077787556,0.026658624,0.023586066,0.07147956,-0.006061751,0.035671275,-0.07906738,0.09858393,-0.026297254,-0.020024106,0.022016075,0.029282846,-0.0069542252,-0.020230982,-0.025348864,-0.0841697,-0.04129189,-0.049597923,-0.038875297,-0.012095663,0.010149193,-0.05144766,-0.030569635,0.026749624,0.040747825,0.064196,0.0032438566,0.0150785055,-0.0077305627,0.004028473,0.03179735,-0.014753391,0.03741561,0.024644082,-0.0067570014,0.02466613,-0.015963975,-0.041581307,0.064786434,-0.03407458,-0.016502596,-0.04411467,-0.04202094,-0.040019117,0.059392832,-0.03210462,0.09272697,0.0053812633,0.04593331,0.019897195,0.012588499,0.06524006,-0.1377929,0.040455397,0.040361293,-1.8011395e-08,0.044542912,-0.07100347,0.031676885,0.0471425,-0.03273219,-0.05550429,0.058446065,-0.0010774253,0.09609333,0.08463165,-0.0028327892,0.054149453,0.034097478,-0.0016204898,-0.014828703,-0.018650385,0.12235861,0.103384756,-0.012428691,-0.009420422,-0.061930597,0.008297782,0.049325787,-0.084904954,-0.026075678,-0.0025392335,0.070001915,-0.061526094,0.037704773,-0.036977958,-0.004942996,0.043237016,-0.005581837,-0.045444258,-0.035304785,0.109040245,-0.010531302,0.029850809,-0.08441008,-0.076062635,0.005657503,-0.078963645,0.00092350855,0.0062241475,-0.038841173,-0.026474075,0.013056097,-0.042194594,-0.02308139,-0.030562729,-0.0020791972,-0.0038371552,0.048611797,0.028319696,-0.06356842,0.010528311,0.011537125,-0.06423789,-0.010635508,0.06689145,0.014389319,-0.07197661,0.008266452,0.08057015 +2.4.1.298,"Isolated from the plants Perilla frutescens var. crispa, Verbena hybrida [1], Dahlia variabilis [2] and Gentiana triflora (clustered gentian) [3]. It will also act on anthocyanidin 3-O-(6-O-malonylglucoside) [2] and is much less active with hydroxycinnamoylglucose derivatives [3]. There is no activity in the absence of the 3-O-glucoside group.",384,0.9999999,-0.035216544,-0.077883415,-0.15014409,0.0021557652,0.050631765,0.07473058,-0.035030417,0.0060408777,0.098920986,-0.027804906,0.0736616,-0.00038147965,-0.04785067,-0.004999131,-0.07042621,0.059843663,-0.010371133,0.07606082,-0.046225507,-0.012284668,0.031588558,-0.00433767,0.06811083,0.006825957,0.018455828,-0.017927133,-0.02114518,0.035054963,-0.0042719473,-0.07931438,-0.025054518,0.03527508,0.015656866,-0.0355316,0.023925534,0.08445226,-0.049908973,-0.024003511,0.07038753,0.029086664,-0.032941524,-0.060884386,-0.0096640615,-0.009268603,-0.056528352,-0.017831553,-0.1145299,0.011579068,0.034429777,-0.038413033,-0.025665682,-0.055059336,-0.04380121,0.048294332,0.01551425,-0.0560357,-0.061000768,0.022242041,-0.0038853358,0.1031979,0.07523881,0.01999782,0.020202534,-0.0038750048,-0.12095548,0.010687142,-0.04110489,-0.017951198,0.07168809,-0.07272182,0.00167033,-0.034820624,0.0723681,0.0050565763,-0.015116184,0.108369656,-0.021120913,-0.02023081,0.020064862,-0.057979066,-0.04426228,-0.015952894,0.0020969699,0.15246004,-0.01880865,-0.041078642,0.0031724956,0.04018381,0.027582107,0.07586223,-0.0038051754,0.08689263,-0.01193122,-0.013074312,-0.04294725,0.029025916,0.07549873,-0.055794936,-0.018757325,-0.0115159275,-0.02448763,-0.010685022,0.05351853,-0.06605727,-0.10464501,0.024186319,-0.011029668,-0.08067257,0.04489074,-0.03598163,-0.084896915,0.0011632942,-0.058066342,-0.048714023,-0.12053084,-0.037559148,0.03633709,-0.07970777,0.0037895672,-0.004406851,-0.067115165,-0.038207546,0.018409552,0.0012369984,0.03657359,0.06361022,0.013553139,2.9902099e-33,0.048495654,0.029484456,-0.048496634,-0.023949863,0.00340247,-0.016448645,-0.005690046,-0.010832176,-0.021414472,-0.015281506,-0.101081714,-0.05506842,-0.023655418,0.03669653,-0.010304927,0.008359918,0.01893998,-0.080890715,0.0540273,-0.006994073,0.07993425,0.1028542,-0.05953281,-0.008184259,-0.024494886,0.0044307965,0.019406721,-0.032873824,0.023757935,0.0073550073,0.06766819,-0.09155442,-0.03597746,0.011967088,0.019256502,0.04857998,-0.14050868,-0.070228785,-0.0108146295,0.07676641,0.006585394,0.04316505,0.07489353,-0.040558472,0.05090486,0.019724963,-0.07808145,0.08763422,0.08842268,0.032035574,0.034899678,-0.015975578,0.015926437,0.05297773,-0.022740884,-0.061069705,-0.06899243,0.038943272,0.05706271,0.03333917,0.0034056744,0.03455068,-0.023406079,-0.052804165,0.039066233,0.0474934,-0.12001033,-0.019070147,-0.039194204,-0.041966513,0.03724511,-0.073522195,-0.005844358,0.012438443,0.07043086,0.009057852,0.0034995226,0.066666506,0.046666805,-0.0050817514,0.033475503,-0.00814524,0.0634055,0.049817063,-0.09456577,0.05094499,-0.0447279,-0.007967504,-0.03440702,0.04495156,0.06851428,-0.043305513,0.02043675,0.014720337,0.022038562,-3.3875506e-33,0.032596413,0.01152342,0.034228917,-0.07780799,-0.008406328,0.07048903,-0.056248873,-0.0153794065,0.0062852614,0.005055485,0.015503535,0.008306559,0.021351075,-0.013677655,-0.063175105,0.0032445667,0.07086161,0.08144935,-0.03090099,0.03282705,-0.115531325,0.046095617,-0.012849701,0.040314686,0.06821742,-0.02996439,0.063665345,-0.010808529,-0.08474065,0.04696862,0.08962334,0.007907883,-0.0394145,-0.0013473646,0.030873109,-0.039199796,-0.04272827,-0.06512363,-0.006445447,-0.007527577,-0.026650663,-0.021108424,0.021865834,0.07255168,0.07785305,0.07086185,-0.07049792,0.02894945,-0.04751035,0.047951654,-0.02395337,0.0054220827,0.012299418,-0.008516794,0.096696824,-0.0033450054,0.07278274,-0.07852081,0.030095821,-0.081590906,0.03146376,-0.04638405,-0.011429554,0.02029984,0.052220073,0.1279742,-0.03279942,0.05905152,0.0017650198,-0.010307579,0.02299252,-0.020315759,0.017793769,-0.024820201,-0.02996507,-0.007983241,0.038624022,-0.080742165,-0.034487728,-0.0092158,0.05637538,-0.0032572772,-0.021463353,-0.11072021,-0.02311819,0.004259754,0.022325212,0.017806198,-0.02712892,0.044636365,-0.01378021,0.0942318,-0.07666042,0.0358009,0.14215063,-4.633063e-08,0.057308838,0.012505568,0.0035441313,-0.01189628,0.015967777,-0.044223312,0.008717639,0.04760311,0.0061272555,0.0473683,-0.009312643,0.053390082,0.043926213,-0.031178394,0.06305167,-0.026944412,0.0709904,0.05623253,-0.029621098,0.026099466,-0.113662004,0.013309045,-0.10703118,-0.036188614,-0.0032925978,-0.09337054,0.08181617,-0.09468846,0.06761954,-0.026406238,0.05387283,0.052565955,-0.016351124,-0.036584865,-0.044336606,0.044670224,-0.002521198,0.037875574,-0.054620337,-0.007592194,0.0121243,0.002644986,0.022813303,0.0064085135,-0.017095141,-0.04997623,-0.0014080717,-0.024408288,-0.013811844,0.029952008,0.0347454,-0.024961865,0.023394892,-0.027984386,-0.065274164,-0.055794477,-0.007243839,-0.0035952874,-0.033973977,-0.066274956,-0.12118544,-0.0750298,0.1579619,0.057279795 +2.4.1.299,"Isolated from the plant Dianthus caryophyllus (carnation). Also acts on other anthocyanidins and with other acyl-glucose donors. cf. EC 2.4.1.298, anthocyanidin 3-O-glucoside 5-O-glucosyltransferase.",384,1.0,-0.10579822,0.01978902,-0.19946095,0.0025876905,0.055544816,0.05889638,0.0495102,-0.013186436,0.049105998,-0.05720029,0.056057286,-0.0297899,-0.13982882,-0.03595252,-0.08352241,0.0072291763,-0.051475443,0.02374302,-0.04020519,-0.014991177,0.0073649976,0.049230333,0.043404292,0.0019921444,0.06296454,-0.07515447,-0.021440133,-0.01745561,0.01324292,-0.08752734,-0.06315661,-0.037802346,0.04657687,-0.0010832363,0.050513484,0.042670045,-0.012418043,-0.03850245,0.024406685,0.031142162,0.06429798,0.021339104,0.041652616,0.008463339,-0.02396928,0.048829947,-0.060981303,0.041190635,0.034171205,-0.018983208,-0.037383914,0.017944962,-0.047726963,0.019429388,-0.009964044,-0.025172912,0.004771166,0.003931783,-0.0012997274,0.058448564,0.04984973,0.02004222,-0.010921096,-0.027956892,-0.12138752,-0.0517783,-0.05486823,-0.030769458,0.11874801,-0.067987226,-0.008288216,-0.06726263,0.047371883,-0.008230404,-0.010714454,0.10040637,-0.06511005,0.02618323,0.04939199,-0.023033667,0.051215526,0.023414044,0.034744147,0.061664607,-0.052512337,-0.0002563405,-0.008827786,0.09223518,-0.028580053,0.028390298,0.0035851717,0.004757869,0.003216705,0.022463094,-0.12270994,-0.005343085,0.13130529,-0.076833405,0.016741225,0.012696001,-0.00812291,0.014005362,0.08109741,-0.08643742,-0.13799636,0.027655318,-0.049986493,-0.04287774,0.073305756,-0.029807672,-0.055959295,0.054240163,-0.047474366,-0.06125024,-0.03480787,0.009391149,-0.016602596,-0.059931815,0.008550879,0.016624818,-0.05765702,-0.01833352,0.03349197,0.03499391,0.028346306,0.051978104,-0.065433726,3.0125935e-33,0.06542817,0.013962319,0.013286401,-0.028984904,-0.02340578,-0.011249122,-0.051380765,0.012619701,-0.0056545394,-0.03743731,-0.08840325,-0.0945239,0.04174908,0.014912591,-0.068851024,0.030804157,-0.044727392,-0.10638191,0.10200084,-0.008082529,0.052364405,0.105114214,-0.099616766,0.009628662,0.019746862,0.006693826,0.0032961427,-0.014073176,0.058934767,0.009713263,0.08692397,-0.107367076,-0.008254491,0.003285071,0.03799835,0.010795969,-0.08024458,-0.08036394,-0.016106497,0.07053191,0.015077995,0.026616285,0.0661988,-0.03238515,0.075415485,0.024133129,-0.045800995,0.045242865,0.068188116,0.07709441,-0.017935324,-0.029387845,0.0967436,0.031059252,-0.06867645,-0.014539419,-0.056227904,0.014218404,0.038578067,0.0414188,0.02176085,0.045529846,-0.007264495,-0.08356181,0.002536137,0.07295588,-0.15099807,-0.051421743,-0.04576004,-0.027396655,0.00062800065,-0.10106061,0.04881503,-0.05140438,0.046552006,0.013396137,0.005701254,0.059563123,-0.020064402,-0.001417956,-0.017732384,-0.00992503,0.097082086,0.0043411804,-0.07479636,0.017011762,-0.045302935,0.011441315,-0.0003074469,0.06967022,0.03465649,0.03680356,-0.03498322,-0.021282481,0.050293785,-2.6012823e-33,0.09534468,-0.01660779,0.006514287,-0.06913227,-0.0016600081,0.05686242,-0.02890528,-0.038725127,-0.022964397,-0.028300248,-0.009699,0.04248955,0.1411222,-0.008579606,0.0017127871,-0.004797123,-0.0021187668,0.10932188,0.005368676,0.065542184,-0.09288334,0.057241857,-0.0119204465,-0.033573627,0.08647491,-0.0021746487,0.029291427,0.016939253,0.026348094,-0.017084569,0.06646596,0.018204456,-0.07523607,-0.020918807,-0.0035797576,-0.034142513,-0.029499924,-0.024754563,-0.0533408,0.02287762,-0.06892297,-0.004143893,0.015162389,0.04685488,0.109714225,0.029344311,-0.010007701,0.049290363,-0.040281646,0.064627424,-0.025233429,0.008819335,-0.012309204,0.02382819,0.051624857,0.03360701,0.08317021,0.011697754,0.017783495,-0.005655436,0.004333278,-0.0832684,0.010668308,0.007561962,0.06016058,0.08765407,0.047971543,0.06415852,0.0074617583,0.004932537,0.06272602,0.022125255,0.033815015,0.061236992,-0.051578473,0.04816647,0.031080555,-0.072353885,-0.047701374,-0.030613981,-0.0026501429,-0.03149341,0.008196562,-0.0115745785,-0.026991118,-0.020432835,0.009062149,0.0025074158,-0.008671193,0.061743014,-0.04458343,0.05828244,-0.053432684,0.030973524,0.090796314,-3.476351e-08,0.060466945,-0.027286243,0.01585941,-0.037672434,-0.019722939,-0.020218484,-0.007171485,0.05535819,-0.026507577,0.016932221,0.019214995,0.044706114,0.022401616,0.012546005,0.048441824,-0.021427983,0.06577561,0.038870655,-0.013533392,0.028815124,-0.11731631,0.012791559,-0.07946966,0.0009849843,-0.07190627,-0.0853129,0.10365113,-0.014547749,0.05384309,-0.083712466,0.03686851,0.0732087,0.0013467347,-0.06627791,-0.025076877,0.056737162,-0.022526914,0.023308758,-0.036023498,-0.024814537,0.012758235,-0.011445494,-0.0016654528,0.015699076,-0.007801066,-0.015320805,0.015108725,-0.037034865,-0.00090264686,0.01659522,0.029593706,-0.017792758,-0.00061651145,-0.04425539,-0.048431676,-0.033252202,-0.045624584,-0.042688247,0.032190707,0.026293397,-0.14006695,0.012927539,0.124679506,0.029572345 +2.4.1.300,Isolated from the plant Delphinium grandiflorum (delphinium). Also acts on other anthocyanidins and with other acyl-glucose derivatives.,384,1.0,-0.07843628,-0.046118807,-0.12774436,0.04400975,0.10786941,0.03652869,0.09080683,0.03605979,0.03537051,-0.03843203,0.068821475,-0.060974166,-0.085296944,-0.0069183446,-0.02703199,0.02139681,-0.034613974,-0.013391625,0.009979852,0.032466702,0.03561114,0.03527531,0.054916188,0.045926202,0.008561231,0.006347377,0.008578541,-0.009093991,-0.0021813586,-0.058917858,-0.05607491,-0.031416193,0.11827548,-0.011373996,0.021829559,0.065595604,-0.078628875,-0.027452486,0.041943546,0.012199224,0.0054895147,0.026125183,0.016212234,0.029455872,-0.08264374,0.040182393,-0.058185376,0.022330774,-0.00077061396,0.06375093,-0.0027123718,0.054299287,-0.03286638,0.08427707,0.031708993,-0.024223844,-0.021715749,-0.02132496,-0.01991703,0.023496397,0.039401423,-0.020216487,0.0170115,-0.032189205,-0.083235346,0.020954968,-0.018155111,-0.033192027,0.123471424,-0.109417826,0.012333107,-0.038794164,0.058341224,-0.0050369888,-0.075609535,0.13764459,0.01650865,-0.042385984,0.028026706,-0.032768935,0.0100374315,0.040083822,0.03164686,0.103560925,0.00026818903,0.0029000887,0.009325256,0.031325977,0.0044784597,0.021464348,0.046697784,0.08146541,-0.06486761,-0.002489097,-0.06944247,0.0099277105,0.07401856,-0.060002793,-0.050728213,0.03986283,0.012379774,0.036242124,0.035132233,-0.11881501,-0.16419625,0.007973746,-0.020439543,-0.07205638,0.03792105,-0.002876602,-0.057025224,-0.01985926,-0.021663763,-0.02187244,-0.053482898,0.011820762,0.05101768,-0.025736403,0.029296575,0.020347074,-0.05725228,-0.01710426,-0.008449388,0.009991744,-0.013274073,0.05665614,-0.03776112,6.958931e-34,0.029936468,0.009737263,-0.09286184,0.014332086,0.031085417,0.026418503,-0.04109341,0.029656664,-0.051615924,-0.027339008,-0.04611468,-0.069998905,0.020894121,-0.01300835,-0.08629923,-0.0020708095,-0.014674064,-0.07257998,0.08686086,-0.05663137,0.021316927,0.14946498,-0.06805887,-0.015863549,-0.024542563,0.013326095,-0.0158969,-0.0007308881,0.061507728,0.0146407345,0.05852333,-0.05765374,-0.023990499,0.058662232,0.04347785,0.09675081,-0.15906194,-0.053694893,-0.009492754,0.0751042,0.030682731,0.016508555,0.057587065,-0.026098719,0.048827272,-0.001388679,-0.09005229,0.05017249,0.07923918,0.012569887,0.004806036,-0.048038386,0.0258926,-0.034600385,-0.07401223,-0.029459527,-0.04944935,0.023689775,0.05942597,0.016855678,0.026969325,0.06793634,-0.056885406,-0.017611695,0.055094615,0.03279214,-0.1968685,-0.024890319,-0.0398111,-0.062404357,0.014639369,-0.07869731,0.03838436,-0.020104907,0.022648353,0.034355137,-0.06266999,-0.008926754,0.034721814,0.011573764,-0.082381226,-0.02063197,0.10043491,0.02868035,-0.06972724,0.023479309,-0.06604735,0.06406523,0.03393749,0.019174939,0.023074195,-0.03956166,-0.08562461,-0.03931637,-0.025792707,-1.5581187e-33,0.036859024,-0.026936933,0.04248586,-0.05780354,-0.016331723,0.07835316,-0.09385682,-0.02887223,-0.0034216263,0.011795822,0.08316656,0.0134762805,0.0077332905,-0.047467895,0.032365903,0.061164293,0.10126743,0.09111007,-0.04386731,0.0036961932,-0.07110861,0.0559303,-0.046289124,-0.005322661,0.016410597,0.012826485,0.090588115,-0.026849503,0.034105994,0.028292658,-0.060440894,-0.008560645,-0.0619525,-0.026364988,0.00477628,-0.03175366,-0.036881045,-0.081842326,-0.048676983,0.0030743538,-0.06856302,-0.03086368,0.057265256,0.07808749,0.104716145,0.016346453,-0.0385632,0.021148633,-0.030798836,0.08066511,-0.010384296,-0.04766901,-0.036922652,-0.060647093,-0.006682335,-0.0023996746,-0.0036289669,-0.021082416,-0.021749336,-0.07732651,0.02180484,-0.019959617,-0.021958722,0.026463931,0.019374644,0.114174195,0.008076728,0.03884321,0.04327838,-0.028233297,0.04420796,0.076336816,0.03525503,0.0005930921,-0.016568543,-0.013710205,0.04302582,-0.055572968,-0.019178152,-0.056772433,0.08951313,-0.0070464686,0.00491841,0.009576227,0.0017449311,-0.013942606,-0.0063653253,0.050420217,-0.025899252,-0.003815543,-0.06851207,0.088098906,-0.06665586,0.035212226,0.12171611,-2.760472e-08,0.02041429,0.008076004,-0.00023847843,-0.007147801,-0.03491079,-0.027394159,0.019436024,0.05969483,0.019676587,0.004334917,-0.008351104,0.1049434,-6.571002e-05,-0.008246153,0.057147764,-0.0543261,0.014877482,0.053854223,-0.025131997,0.018443188,-0.08331486,0.038806822,0.00038612104,-0.009244758,-0.04337621,-0.062011156,0.068828836,-0.08634148,-0.009017455,-0.0417561,0.050595988,0.031525765,-0.053196073,-0.020877944,0.0560295,0.06509183,-0.022981424,-0.06838594,-0.0478839,0.012160196,0.028441483,0.03654208,0.00042494774,0.041616622,-0.0033844959,-0.06584193,-0.07515521,-0.016526062,0.0024556315,0.028583942,0.0049255267,0.03661412,-0.0032522401,-0.012720444,-0.05148756,-0.040467143,0.012150722,-0.04910544,-0.07309637,0.018378785,-0.049739286,0.015265518,0.146384,0.02434122 +2.4.2.49,"Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. The enzyme requires a divalent metal ion, optimally Mg2+, Ni2+ or Co2+.",384,1.0,0.022151377,-0.03427483,-0.06573828,-0.050333615,-0.001812558,-0.0036885983,-0.10274386,0.060205642,0.085996866,0.0055267843,-0.07081922,0.029824775,0.13552587,0.15068848,-0.042666104,-0.028934572,-0.039765637,0.05508655,-0.037705895,-0.0052088737,0.035170805,0.07572139,0.035887465,-0.014927963,-0.004159918,-0.007722157,0.0040458995,0.033783637,-0.008688498,-0.0011238747,0.047132097,-0.04598495,0.010849013,-0.05442331,0.065809965,0.066522524,-0.067033574,0.044888385,0.1095677,0.04154529,-0.06805638,-0.0012583338,-0.016339501,-0.021183947,0.03695647,-0.067389324,0.027003301,0.019665442,0.05974847,0.07400561,-0.06870782,0.01929364,-0.051256415,0.038444467,0.094911456,0.074114986,-0.048750028,-0.07685269,-0.009293852,-0.048251096,0.031145269,-0.053195853,0.014319494,-0.01093055,-0.06790636,-0.010578662,0.00913471,-0.061042197,0.047726184,0.0029916249,-0.034204826,-0.10066351,0.037931982,0.03370034,-0.006730484,-0.062843785,0.07051335,-0.02748308,-0.05580073,-0.08192427,0.029957479,-0.028984731,-0.001854852,0.09334414,0.08491756,0.04138727,0.10608863,0.001288569,0.017146977,0.07883311,0.07546538,-0.011548822,0.043422986,-0.08770037,-0.013903686,-0.0831744,-0.0232018,0.017999731,-0.01306934,-0.028798575,-0.0007621458,0.0008401396,-0.04000361,-0.026672058,0.0023330299,0.012649888,0.037192654,0.057359397,-0.037074696,-0.0042324164,0.029776268,-0.014652272,-0.045280296,0.016620869,0.022669217,0.11098751,0.11005756,-0.0573,-0.086656906,0.051185142,-0.004804818,-0.0076477984,-0.002651542,0.024581406,-0.059035487,0.0463338,-0.020005109,2.6083219e-33,0.014036644,0.07743913,-0.012672666,-0.024958758,0.026087757,0.018403701,-0.06529113,-0.049708977,0.058658663,-0.033349503,-0.07876893,-0.066415824,0.031068055,0.004791197,-0.021422291,-0.053237654,0.00017274548,-0.0068375766,-0.011095747,0.020059356,0.0112286685,0.043994065,-0.009901191,0.057766058,0.048996307,0.0634402,-0.00931581,0.011294285,0.06380999,-0.026091423,-0.037999224,-0.06344012,-0.040125035,0.007286293,0.030743558,0.0071104923,-0.038769018,-0.0025650389,0.124629416,0.054349616,-0.039186213,0.017576002,-0.10257909,0.009663708,0.090816185,0.00045397354,-0.05644289,0.10572371,-0.044661004,0.015212512,0.09922103,-0.05503935,0.03584004,-0.0656055,-0.07463824,0.018356042,-0.054270577,0.009042693,0.016822979,0.03041049,0.020745052,-0.0682905,0.039759543,0.02682436,0.072927885,0.0048528374,-0.038180225,-0.06694997,-0.033207715,0.013930668,-0.1187418,0.0054502515,0.067820534,0.0532906,0.0049775564,0.025438491,-0.07518205,-0.048275508,0.10806085,-0.01947522,-0.01860245,-0.0014381713,-0.062700495,0.0058278027,0.023942849,0.0016189715,0.01325484,-0.07746713,0.005010671,0.03755087,-0.0011257982,-0.09411201,-0.06930208,-0.0014437949,0.0028599799,-5.4784935e-33,0.104350924,-0.052623075,0.076911345,-0.027125457,-0.05519975,0.09133978,-0.05988438,-0.1303803,0.068769276,-0.010560445,0.06670663,-0.026678864,-0.032173168,-0.05534529,-0.05859288,-0.014126123,-0.0193335,0.044383656,-0.015850795,0.014764136,0.022254487,-0.026638554,-0.033464663,-0.021190848,0.012077472,0.0879823,-0.056726936,0.016551286,0.06315787,0.088791884,-0.0036017857,-0.0078049167,-0.04625064,-0.12084627,0.01612262,0.15047951,-0.041950703,0.014876348,-0.05827577,-0.019256633,-0.02951888,0.022791672,0.009095608,0.09037975,-0.009942425,-0.015387373,-0.06767248,-0.037672844,-0.0028931585,-0.11411192,0.0382882,-0.0045698658,0.049099304,0.030114552,-0.03463018,0.0056283977,0.031175649,0.011572139,0.06925003,-0.0057289884,-0.03993473,-0.027184438,-0.0048431284,-0.016479546,-0.032141585,-0.017712519,-0.010795884,-0.035824373,0.040336065,-0.030551968,-0.024649326,-0.01107749,0.079973996,0.017759297,-0.009467627,0.0597593,-0.03950183,-0.11595225,-0.008714446,-0.008310429,-0.052549884,0.07971581,-0.04901114,-0.0112955775,-0.0347674,-0.048013847,0.084872544,0.04449751,0.007862529,-0.04213825,-0.0011158184,0.014885066,-0.0018296847,-0.026793405,-0.017608302,-3.8406963e-08,0.066021085,0.023146853,0.04687563,-0.045726024,0.025314247,0.01423886,-0.08268364,-0.061716706,0.03294263,-0.010258277,0.012354915,0.09991335,-0.0009186599,-0.022570474,-0.032362074,0.04805461,-0.05649316,-0.014743387,0.014719545,-0.04775858,-0.10778933,-0.01102275,-0.117522605,-0.032495894,0.09102803,-0.037758805,-0.016214306,-0.0051630973,-0.04080388,0.01933495,0.067844145,-0.016394936,0.027484018,-0.04170882,-0.051375464,-0.021669066,-0.028888125,-0.011007278,0.04467983,-0.0843454,0.04258735,-0.03092938,-0.05534891,0.025682542,-0.023292672,0.0061376174,-0.010316292,0.009216153,-0.0756928,0.015739636,0.015085569,-0.03073701,-0.013542559,-0.043089747,-0.08350526,0.064618856,0.010508907,-0.07285579,-0.0015812343,-0.065755576,-0.10186869,-0.025697777,0.09734854,-0.07312854 +2.4.2.50,Isolated from the plant Daucus carota (Afghan cultivar carrot).,384,0.99999994,-0.10611517,0.03214496,-0.13874198,0.033715565,0.03667283,0.018587496,-0.022932997,0.017101204,0.059042968,-0.058570884,0.12904789,-0.06183736,-0.042325094,-0.04818809,-0.017097138,0.012194255,0.06948857,0.0018453089,-0.020705294,-0.06222069,0.015696567,0.093558386,0.023180028,-0.0067908447,0.017235186,-0.05933787,-0.04637157,0.026812261,-0.0011270327,-0.056279346,-0.044654526,-0.028618218,0.027956031,0.017173989,0.04762938,0.015843667,-0.0048218295,-0.0045210854,0.09213318,0.011887376,0.014092401,-0.031954903,0.03153197,-0.025433773,0.03575745,0.0061106593,-0.16198151,0.044135477,0.032146577,-0.061969094,0.01954279,0.014172816,-0.0316628,0.0077327546,0.00810349,-0.024822116,0.03006495,0.043480292,0.029051958,0.10311582,0.06537199,0.04308405,-0.00377111,0.010000371,-0.09465592,-0.0025934235,-0.044830937,0.0036147516,0.124438226,-0.025120676,0.040543098,-0.038435653,0.030974742,0.022728793,-0.053464774,-0.049114466,-0.031971723,0.05309321,0.018975604,0.021588866,0.049497385,0.07783991,0.04899246,0.034544047,-0.014595472,0.033006664,-0.027573043,0.026195638,-0.07266438,-0.025622798,-0.0054206755,0.0318741,-0.034453444,0.021009553,-0.016095718,-0.04784583,0.14771557,-0.042432316,-0.030525902,0.045207966,0.024845952,0.002265074,0.026048625,-0.11749506,-0.08363718,0.046354305,-0.040653635,-0.08608241,0.043249812,0.0067168125,-0.052409235,0.0542307,-0.081016414,-0.09644604,-0.045244593,-0.046567794,0.016018339,-0.044902667,-0.002548805,0.0040692636,-0.01642457,-0.023338625,0.07725049,0.03400804,0.045628563,-0.018570941,-0.022628974,-4.2589327e-34,0.040796444,-0.042163856,0.014225804,-0.064675465,0.021559574,-0.04259797,0.02138487,0.009735882,-0.029920714,0.0456143,-0.04998526,-0.11194892,-0.07801676,-0.008079869,0.009771208,-0.008490482,-0.02830896,-0.0255096,0.07464555,-0.051534303,-0.023216365,0.05842224,-0.028050767,0.00846212,-0.026534488,-0.023478027,-0.0484186,-0.09425018,0.07950245,0.018514993,0.050813545,-0.07527568,-0.026393903,-0.009690593,-0.06179295,-0.0062435805,-0.12459687,-0.0809211,0.023764767,0.045935072,0.10455927,0.011448504,0.07419704,-0.017207753,0.04155452,0.056074344,0.008631092,0.057963308,0.037319057,-0.021828748,-0.0015163646,-0.028956698,0.02472541,0.041278366,-0.060878176,0.042270858,-0.005822378,-0.00082927407,-0.03228561,0.054473758,-0.007547449,0.04833602,-0.056793373,-0.00056381186,0.00014131292,-0.0014665573,-0.17431995,-0.0070304326,-0.0017390415,-0.0070627397,0.02189555,-0.061173286,0.01211467,-0.08632047,-0.014006133,-0.0047523146,0.041334476,0.07310625,-0.047036212,-0.0016609784,-0.0077020996,0.045157954,0.029208846,0.001653654,-0.023767387,0.049142182,-0.06151562,-0.04295477,-0.001804773,0.08027827,-0.04350538,-0.00088411325,-0.06751172,-0.057988256,0.071039565,-1.2522755e-33,0.04384258,0.039079074,0.01829831,0.0014503032,0.033049203,0.07323777,-0.06584836,0.037450567,0.048850626,0.015905313,-0.08402374,0.05478171,0.041478742,-0.054401815,0.030601995,0.12793991,-0.0025830083,0.15606014,-0.038723156,-0.022152968,-0.103568874,-0.0064930418,0.0325024,-0.06335322,0.041751698,-0.0064936792,0.010005737,0.013180993,0.06067369,0.004724039,0.06964428,-0.014650005,-0.0690866,0.04517312,-0.06806004,-0.008807251,-0.063162304,-0.092066,-0.028423162,0.074035026,-0.058731437,0.029164711,-0.004912588,0.048946053,0.094051376,0.04195008,0.030706502,0.045911107,-0.028650569,0.025475916,0.08734113,-0.0036103767,-0.0042233053,-0.006714784,0.03926006,0.0049237194,0.075095996,0.06272465,-0.0512554,-0.060301468,0.058579322,0.0033230819,-0.057910398,0.025931615,0.049485147,0.06907432,0.04484176,0.04473214,-0.019790333,-0.001038695,0.033963174,0.052737467,-0.017265622,-0.026078269,0.010983033,0.0462939,-0.022496108,-0.004289198,-0.017739287,-0.0152270235,0.004195458,-0.027755726,0.042939514,-0.04306898,-0.021940209,0.012837744,0.02282561,0.013648233,0.0374285,0.06605037,-0.055781353,0.043422762,-0.092042446,0.01928362,0.074546516,-1.858852e-08,0.109276,-0.011074374,-0.037042223,-0.07681127,-0.04413926,-0.031182447,0.005772394,0.022528965,-0.037160862,0.013134829,-0.055157065,0.017057618,-0.053133193,-0.002110459,-0.023245657,-0.058769003,0.08151198,0.04793794,-0.016860252,0.032818995,-0.09158104,0.03167704,-0.020673234,-0.030071408,-0.0674731,-0.032594886,0.07402355,0.0041871425,0.11461636,0.05889794,0.06168166,0.0489603,-0.074747406,-0.12115394,0.037560742,0.018080078,-0.07372041,-0.0057682246,-0.01492411,-0.031247916,-0.044318415,-0.020936323,0.019539969,0.029889263,-0.09256133,-0.005484109,-0.0060821977,0.014326123,-0.030947203,-0.0137995,-0.02512752,-0.017340932,-0.023991989,-0.030919136,-0.075225435,0.00041258094,0.043729436,-0.0383905,0.010460504,-0.019303631,-0.12320455,0.017673131,0.11667222,0.11083546 +2.4.2.51,"Isolated from the plants Matthiola incana (stock) [1] and Arabidopsis thaliana (mouse-eared cress) [2]. The enzyme has similar activity with the 3-glucosides of pelargonidin, cyanidin, delphinidin, quercetin and kaempferol as well as with cyanidin 3-O-rhamnosyl-(1->6)-glucoside and cyanidin 3-O-(6-acylglucoside). There is no activity with other UDP-sugars or with cyanidin 3,5-diglucoside.",384,0.99999994,-0.11767376,-0.14649081,-0.12136274,-0.023738483,-0.011294279,0.026232794,0.041496046,0.04872854,0.03198111,0.024967689,0.08249892,-0.04410162,-0.11241461,0.04711703,-0.06348249,0.024487257,-0.020297576,0.05592171,0.0003209921,-0.067929536,0.006595987,0.021286367,0.059026696,0.046804715,0.051824268,0.0075107566,-0.016662339,0.0044843815,-0.0433728,-0.04647873,-0.077829085,-0.048663273,0.047633875,0.018957706,0.04015021,0.11474641,-0.068379045,-0.066893406,-0.001696442,-0.071342535,0.026905358,0.018994493,-0.010226417,0.034163456,-0.0076823332,-0.081473716,-0.1084786,0.025032567,0.030989692,0.012184856,-0.007076873,-0.023561776,0.033141013,0.06435818,0.027706455,0.0018185261,-0.06572946,-0.029593857,0.009655082,0.087185636,0.010394827,0.009489025,0.0057190694,-0.014317133,-0.08343857,-0.0012275722,-0.03423234,-0.0028271994,0.038433917,-0.018115615,-0.033174004,-0.07427006,0.0068789804,-0.045612343,-0.033630546,0.09550095,-0.0023822438,-0.039675042,-0.04805423,-0.05356663,0.059565183,0.018882368,0.034416076,0.09973957,-0.025215292,-0.028305277,-0.0066466047,0.06609451,0.025664987,0.0071740225,0.053668715,0.118915625,-0.053768713,-0.009493989,-0.010560736,0.015111685,0.03566998,-0.050728623,-0.036504287,0.008209689,0.026697377,0.06293392,0.0639333,-0.15493244,-0.055471953,0.08664381,-0.052235164,-0.058039732,0.031140393,0.00503626,-0.0472822,0.025992509,-0.059873454,-0.010002043,-0.009220962,0.009111276,0.028029064,-0.021773903,-0.0059991525,0.035518087,-0.0680059,-0.025862025,0.017884005,-0.049131237,0.010980143,0.011319398,-0.078329474,2.863177e-33,0.042241275,0.009078403,-0.056006543,-0.03912435,0.07583694,0.026058247,-0.009854415,0.07541623,-0.04068953,0.007681049,-0.11742237,-0.041634932,0.011407259,-0.0040253904,-0.043868225,0.020024784,0.0005022612,-0.06708125,0.109920256,-0.014432805,0.02734706,0.035176173,-0.093305536,0.009743541,-0.006008028,0.02877664,-0.029901756,0.03876773,0.07417001,-0.019783368,0.014153949,-0.05215543,-0.05736041,-0.028229859,0.0965794,0.031912554,-0.04914369,-0.04857194,-0.040838715,0.07021021,0.011564997,-0.017599788,0.06618856,-0.051298443,0.046695262,0.015988307,-0.10940357,0.034169212,0.031202795,0.049234595,0.07154602,-0.036737766,0.06184257,0.021114193,-0.014065784,0.003578337,-0.058115825,0.014511079,0.06594171,0.050118364,-0.019406153,0.026400495,-0.02327511,-0.094574176,-0.032972038,0.09087949,-0.13955858,-0.048086565,-0.053571947,-0.022553155,0.010214219,-0.03505412,-0.035780676,0.018168043,0.09749922,-0.023972377,-0.015711563,0.0952612,0.0160537,0.03123048,-0.04426791,-0.028465696,0.059980866,0.07975149,-0.027218176,0.0075172405,-0.041997842,0.023876471,0.045248974,0.02720925,0.033309918,-0.038194917,-0.08021319,0.026020322,0.043592703,-3.691067e-33,0.062548436,-0.029139284,0.07319041,-0.045959756,-0.02962867,0.06446976,-0.025800744,-0.029972076,0.036884837,-0.05418707,0.07559048,0.032639258,0.06356996,-0.043592006,0.005508442,0.07800021,-0.00046712448,0.10148546,-0.052940458,0.063018076,-0.07026351,0.027510094,-0.031240629,-0.002682061,0.118798405,0.007591166,0.03375335,0.03371958,-0.02129888,4.005802e-05,0.04876835,0.000977436,-0.07537497,-0.09900601,-0.016449723,-0.021934288,-0.04752525,-0.07134249,-0.0141125955,0.05605517,-0.022367192,0.04224075,0.030727066,0.070436075,0.046412878,0.057815492,-0.056406893,0.010996866,-0.10520573,0.055170614,0.030595072,0.027181134,-0.001787509,0.0014450109,0.0860752,0.06569713,0.09331408,-0.0042048167,-0.014875041,-0.0066278134,0.008654349,-0.08816478,-0.052823093,0.028451174,0.091674216,0.06902372,0.0060154605,0.035421357,0.0056002447,-0.011204727,0.033669677,-0.030610306,0.029988926,0.004978305,-0.052931182,0.042885035,0.0064817397,-0.0415614,-0.0018598388,-0.036221772,0.080999,-0.01850732,0.0104506975,-0.020158833,-0.058622196,-0.02415587,0.065222904,0.031735007,-0.01752921,0.013336629,-0.010368275,0.03990437,-0.039031416,0.044332236,0.12465906,-4.5158526e-08,0.052241992,-0.008488434,-0.015320867,-0.08593583,-0.0059652203,0.0044579487,0.011738631,0.050309394,-0.023243865,0.026169984,-0.02590188,0.06969268,-0.009589433,0.03796238,0.022098223,0.018998332,0.046206214,0.027868306,0.0072256597,0.039277654,-0.10375506,0.06053398,-0.11828701,0.034717917,-0.038123064,-0.08281322,0.08431826,-0.009266946,0.011738016,0.013772559,0.011711945,0.04268782,-0.000725994,-0.04797074,-0.03344124,0.044275895,-0.016943194,-0.0750117,-0.0678601,-0.030108474,-0.0284888,-0.042336404,-0.017969903,-0.04096679,-0.055570997,-0.05145624,0.020012498,0.025011186,0.00062676147,0.03639036,0.009396274,0.016546836,0.013990803,-0.0829588,0.01878848,-0.05105276,0.023893828,-0.0679573,-0.061635043,-0.03960054,-0.11017617,-0.090342686,0.13107102,0.02631722 +2.6.1.100,"Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Also catalyses EC 2.6.1.101, L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase [2].",384,0.99999994,0.04009277,-0.05591865,-0.06140075,-0.083700106,0.023778792,0.056075126,-0.09477366,0.069555685,0.09091818,0.013458241,-0.018191975,0.017449526,0.092379585,0.08469065,-0.04515164,-0.008037947,-0.09360254,0.0068135248,-0.050329234,-0.023709612,0.021800416,0.07797044,0.015567397,-0.011032281,0.020680044,0.004266591,0.028345732,0.02201919,-0.036681127,-0.041112088,0.045485485,-0.07242622,0.0013491458,-0.024682403,0.0831402,0.032181516,-0.07382574,-0.031959362,0.16891523,0.03591175,-0.08832285,-0.03291704,-0.04480982,-0.06203067,0.026711611,-0.0318241,0.037329417,0.024988648,0.047043547,0.035200015,0.005964139,-0.016089682,-0.033975203,0.01999058,0.10016807,0.040698227,-0.07928769,-0.077227026,-0.010092434,-0.012811648,0.0074874815,-0.026972951,0.021656632,-0.028714044,-0.10096576,-0.019354476,0.051651593,-0.08443534,0.078003995,-0.015029943,-0.041161932,-0.09701073,0.05358775,0.06063881,0.015827809,-0.054747045,0.01053598,0.0020865002,-0.04836384,-0.08829649,0.034580234,-0.04911978,-0.021710353,0.093659654,0.04990957,-0.0046937405,0.051485624,0.0072074616,0.03890819,0.044724967,0.082347184,-0.04460359,0.066961884,-0.06113133,-0.035000637,-0.07263322,0.01007049,0.046164725,0.009729406,-0.04947387,-0.023658752,0.024451297,-0.06072416,-0.059824105,0.027497848,0.011106886,0.08016703,0.088311695,-0.038294807,-0.08768388,0.007178173,-0.03477412,-0.031055221,-0.006801858,-0.04452575,0.11801848,0.14872065,-0.0500402,-0.072385274,0.049242087,0.021198936,-0.025016505,0.04433306,0.06260221,-0.08148424,0.036780175,-0.017852684,3.216551e-33,0.017386908,0.062201906,-0.00086262915,-0.03634029,0.057902217,0.02135064,-0.09307247,-0.043191887,0.05762237,-0.064761296,-0.1146857,-0.042657617,0.030933151,0.032906894,-0.03180736,-0.0030480376,-0.027864955,-0.018507194,-0.040795024,0.0073462357,0.019003954,0.030232681,0.014476621,0.059954263,0.0062604332,0.06986172,0.0058995825,0.00957463,0.086780496,-0.003972321,-0.07456018,-0.057328273,-0.024199748,-0.000520294,-0.024717765,0.026249908,-0.06535308,-0.008428573,0.14596188,0.08131352,-0.01905601,-0.0006075242,-0.07624425,-0.020526974,0.06945981,0.022228718,-0.02687601,0.09878168,-0.02746941,0.02622148,0.08602173,-0.08556885,0.032458305,-0.03766172,-0.051990468,0.0064326837,-0.06380044,-0.017201234,0.026171088,0.09336462,0.024440188,0.0024274974,0.043122977,-0.013747806,0.014623776,-0.00835201,-0.030391991,-0.038759097,-0.039500196,0.014855559,-0.088900775,-0.01359461,0.11740052,0.075391404,0.047357373,-0.009616622,-0.07577623,-0.026314383,0.066312574,-0.0007128129,-0.0022983334,0.017581604,-0.016985467,0.03557455,0.019654151,0.008179079,-0.022774322,-0.09991705,-0.014192926,0.08312071,-0.06120866,-0.06406222,-0.06627453,0.0070955926,-0.02618839,-5.3711856e-33,0.085099615,-0.06330466,-0.0024830657,-0.046261467,-0.02922429,0.08151532,-0.018745469,-0.08346687,0.078187175,0.015174618,0.08616115,-0.022681776,-0.0030477676,-0.059636846,-0.03418532,-0.047913972,-0.010957965,0.0362403,-0.025838625,0.020537969,0.048500977,-0.064035855,-0.043373957,0.0027033696,0.04449648,0.075873435,-0.049933225,0.032154102,0.056113936,0.063316755,-0.029787794,-0.032193486,-0.0002159354,-0.06300301,0.035093397,0.11716591,-0.024422027,0.03774762,-0.05680142,-0.035643898,-0.033804383,0.0250679,0.009776633,0.060012102,0.029699339,0.017944196,-0.03464768,-0.027526345,-0.044466496,-0.09248266,0.058838263,-0.00071816385,0.02562793,0.03277166,-0.008789558,0.027401846,0.0074820085,-0.006199424,0.06327543,0.043833263,-0.06624649,-0.051004604,0.008796551,-0.00019826106,0.007926168,-0.02877353,-0.018987633,-0.008927796,-0.009274583,-0.01928119,0.033842146,-0.06310997,0.028732281,0.032361526,-0.019380033,-0.00039847323,-0.06546195,-0.1242859,-0.011971879,-0.039743893,-0.014836426,0.00430607,-0.008371284,0.005950865,-0.028383829,-0.03734412,0.08608097,0.08822617,0.017579298,0.0111248,-0.002618252,0.04125267,-0.015361374,0.00079353485,0.03101357,-4.2460613e-08,0.0979503,0.0066769687,0.033740494,-0.003524147,0.040193055,0.013570129,-0.06780399,-0.012191201,-0.00014080052,-0.06217634,0.013809605,0.10012767,-0.012270013,-0.032365587,-0.0649481,0.051625427,-0.049707882,0.017893095,0.028694658,0.002716096,-0.11595079,0.011370078,-0.09702911,-0.057057567,0.07179268,-0.03898753,-0.0044021797,0.027892008,-0.025668219,-0.06709607,0.06527419,-0.016955158,0.002347603,-0.0572214,-0.05400788,-0.025254063,-0.046055,-0.02752891,0.04573486,-0.029183852,0.003927423,0.018179625,-0.04445044,0.016709328,0.009446494,0.017231708,0.004743509,-0.020812383,-0.052060593,0.026159035,0.046667237,-0.018882446,0.025874685,-0.040141094,-0.0894499,0.025191087,-0.056898315,-0.07576583,0.0137419,-0.09037688,-0.07020486,0.004047913,0.15141101,-0.009682898 +2.6.1.101,"Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Also catalyses EC 2.6.1.100, L-glutamine:2-deoxy-scyllo-inosose aminotransferase.",384,1.0,0.01759747,-0.0466034,-0.071850054,-0.063244894,0.03335303,0.04129363,-0.106284454,0.07732311,0.09639577,0.031852912,-0.01434722,0.022110306,0.100518785,0.08929223,-0.0362005,0.013016699,-0.09310011,0.013495412,-0.0519669,-0.025070833,0.025216596,0.08203133,0.011278679,0.0025214278,0.016800517,-0.011308963,0.0085120695,0.035521634,-0.051726248,-0.053193264,0.044603128,-0.04732812,0.0075883907,-0.03704286,0.07597704,0.0404527,-0.06606966,-0.007786113,0.17292763,-6.676121e-05,-0.093290105,-0.021587277,-0.04471251,-0.054030325,0.01633497,-0.042871494,0.044375803,0.03640833,0.044933833,0.028909897,-0.016379204,-0.014400999,-0.026678884,0.004532784,0.09021009,0.053368036,-0.0796308,-0.07028634,-0.016042432,-0.036769614,0.008217938,-0.039145928,0.011123225,-0.008019448,-0.101845235,-0.043108474,0.07774164,-0.056699872,0.068120986,-0.015271978,-0.027981667,-0.10719178,0.05572543,0.07495217,0.032639563,-0.03283915,0.011496628,0.00073263433,-0.04737883,-0.0771973,0.05304331,-0.06798856,-0.0155631,0.084167704,0.06758823,-0.025266102,0.06106458,0.0011176367,0.04804998,0.050832245,0.07388577,-0.058585815,0.054941144,-0.056127407,-0.027364973,-0.08054838,0.017229086,0.06983534,0.008097938,-0.039444286,-0.019525541,0.021882238,-0.057501193,-0.057176344,0.04785002,-0.0067688813,0.08066198,0.076706044,-0.03279353,-0.08073546,0.031519096,-0.060240913,0.0011817879,0.011702405,-0.032627188,0.117479354,0.15096244,-0.033265922,-0.050990216,0.03871173,0.023372823,-0.010451652,0.030761443,0.061778698,-0.10932902,0.056271337,-0.028253661,2.6731197e-33,0.0006581623,0.066568226,0.0041133785,-0.0029214334,0.031389594,0.009697739,-0.0971698,-0.0301408,0.033702336,-0.065270536,-0.117996745,-0.037678137,0.054903034,0.054311942,-0.022413438,-0.015615277,-0.022393122,-0.02900904,-0.040843192,0.011390972,-0.0064850226,0.02687552,-0.013826512,0.052491657,0.025374515,0.06956427,0.008726505,0.006503929,0.07994855,-0.00038735342,-0.047325972,-0.049261127,-0.044043716,0.02822594,-0.03178552,0.02924834,-0.06044069,0.0051935525,0.12380792,0.064520136,-0.018971398,-0.0016339191,-0.09762224,-0.030986493,0.051719066,0.02171151,-0.029473556,0.0829754,-0.032750282,0.022200672,0.093503326,-0.07838915,0.027450502,-0.04219424,-0.05562311,0.027179644,-0.032230515,-0.018596418,0.042718798,0.10622893,0.0037990978,-0.014049894,0.022963574,-0.013029282,0.03216118,-0.02250968,-0.04659534,-0.048553124,-0.07487423,0.007184918,-0.09882146,0.0068824375,0.11649454,0.061849434,0.017293993,0.0068690605,-0.07957097,-0.027091404,0.0656523,0.010965224,-0.005660672,0.0040201736,-0.024670774,0.038403317,0.013597185,0.007341972,-0.01587833,-0.08456067,-0.02215752,0.08126697,-0.072665386,-0.07802702,-0.076721385,-0.0032549438,-0.0028445497,-5.509186e-33,0.070856504,-0.048360985,0.019590724,-0.045486428,-0.032003332,0.10408766,-0.0004727907,-0.088894516,0.10179039,0.0021568073,0.077847995,-0.023991033,-0.0032753048,-0.060022607,-0.032299317,-0.05760096,-0.028272323,0.014477019,-0.026222678,0.016137507,0.03859231,-0.030131474,-0.033217806,0.0096627185,0.024848664,0.066479094,-0.044986498,0.033230558,0.035762966,0.072991215,-0.028606042,-0.027213419,0.004886105,-0.05441166,0.019536983,0.119393244,-0.03611388,0.020665746,-0.061471365,-0.035214763,-0.03545591,0.046424277,0.006600786,0.066739164,0.030268695,0.020134596,-0.05209002,-0.03055699,-0.042933386,-0.09036151,0.058777705,0.010646409,0.020212125,0.032980673,0.0038138577,0.012451263,-0.011901326,-0.013328143,0.04643223,0.02584849,-0.06504233,-0.034304563,-0.0030839215,-0.0028746973,-0.0044589904,-0.02319604,-0.043093465,-0.013863934,-0.0108501585,-0.019093035,0.021614384,-0.06890698,0.002809098,0.022691572,-0.013210162,-0.001674278,-0.104028754,-0.11402563,0.00390919,-0.040070295,-0.029048823,-0.0029221633,0.0068053026,0.015080033,-0.014592228,-0.04723148,0.05855278,0.07469028,0.033169128,0.010435443,-0.0015880896,0.031771336,0.00085714506,0.013713642,0.03473434,-3.937738e-08,0.109652534,-0.0125219915,0.046072382,0.0057201358,0.03361801,0.0062968745,-0.06114496,0.0006708091,0.010358154,-0.041140456,-0.0046843784,0.102268666,-0.0010776033,-0.03758185,-0.07256147,0.07672803,-0.042765435,0.017135562,0.017376496,-0.00761638,-0.107922144,0.018413901,-0.09501046,-0.04082282,0.081656456,-0.037318926,-0.009463462,0.014237634,-0.014152498,-0.06974454,0.051590107,-0.024672233,0.0010518399,-0.053564362,-0.07023837,-0.048054587,-0.043046344,-0.038032826,0.047796387,-0.020054113,0.032484263,-0.0004206477,-0.05632611,0.0056499694,-0.009568626,0.035817012,0.008992707,-0.00566157,-0.06413053,0.013396733,0.0239595,0.011312703,0.024550613,-0.024545481,-0.10722107,0.048720304,-0.05346171,-0.062046267,0.023755644,-0.08419254,-0.073302455,0.016046735,0.15368952,-0.028421309 +2.7.7.84,"The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity [2].",384,1.0,-0.008875885,-0.05469403,-0.012845727,-0.034183383,-0.0014365861,0.02999492,-0.09012424,0.051684808,0.040061347,0.009236157,-0.0020215162,0.06159901,-0.06813622,0.028898396,-0.016774984,0.10206465,-0.1357327,0.021372713,-0.108872525,-0.09148326,0.0963371,0.034218308,-0.007267771,-0.015318851,-0.042059973,-0.025616363,0.07353149,-0.02484774,0.036469206,-0.08379216,-0.011573327,0.006636631,0.080850415,-0.014479053,-0.038816866,0.043411776,0.010817183,-0.040729858,0.031017374,0.06716711,0.10652484,-0.06299435,-0.035549305,-0.037657063,-0.09201249,-0.036136698,-0.015621177,0.03556007,0.0061369506,0.04206709,0.032924555,-0.048851833,-0.038069066,0.0064148596,0.0121942535,0.07693137,-0.058762312,0.025297644,-0.020511447,-0.018734096,0.056258764,-0.007233989,-0.017829506,0.020144887,0.039635323,-0.06491416,0.060245954,-0.037715036,-0.037396803,-0.0251558,0.029779539,-0.014193685,-0.03224566,0.04241923,0.041310254,-0.052962437,-0.035897717,-0.0405565,0.07127535,-0.0067094187,-0.048720464,-0.034036174,0.07207844,0.07432401,-0.021169646,0.09039243,0.027913952,0.016374463,0.055793684,0.036121946,0.0049404576,-0.060309727,-0.07661968,-0.029954761,-0.067307636,-0.007474218,0.022882542,0.012053984,-0.013923724,-0.038836494,0.06810883,0.027249733,-0.07324078,-0.044185523,-0.023379736,0.03235995,0.067935385,0.0029741272,0.021255748,0.039786138,0.0666573,0.012474888,0.13916557,0.017967276,-0.050782423,0.027101295,0.008141227,-0.035606284,-0.016422415,-0.03787986,0.075299956,-0.013761891,0.022682484,0.039532673,-0.06146261,0.048009135,-0.038465355,-9.418467e-34,0.0038476342,-0.008830961,0.0055626864,0.060054783,0.025807876,0.014902339,-0.031610142,0.0023448765,-0.09374166,0.014178474,-0.03723521,-0.05940388,0.046652578,0.073090956,0.016476423,-0.021021489,0.03719754,0.023024723,0.009102317,0.015901715,0.03182629,0.08387542,-0.022613717,0.07303173,0.026684243,0.0027042625,-0.028215978,-0.0027824175,0.039335266,-0.023437522,-0.0057467576,-0.026768422,-0.12308113,0.027601335,0.054742575,0.0033033,-0.01937398,-0.0050511076,0.019433022,0.0596139,0.042943455,-0.03140408,-0.0024416288,-0.031081257,0.016521387,-0.029402854,0.0077897864,0.04053854,-0.01194508,-0.011342888,0.091734655,-0.028778836,0.064554565,-0.051087193,0.0040503466,0.033110335,-0.09568732,-0.10186307,0.020775331,0.08837421,-0.027042072,0.02419206,-0.020146638,0.08057934,-0.0033217873,0.018688831,-0.008234767,-0.13779736,-0.0024433965,0.1024545,-0.027076267,0.0017240387,0.06557237,-0.009603702,-0.008796191,-0.011479897,-0.06315644,-0.05228658,0.039422516,0.06744524,0.008216323,-0.08277919,0.021455621,-0.018557567,-0.06439175,-0.08799518,-0.008381228,-0.0912257,-0.015509568,0.07073146,0.048006807,-0.06659784,-0.06326613,-0.00070951495,0.05958634,-1.5838967e-33,0.043434493,-0.0462154,0.05499094,-0.032551922,-0.10258607,0.050375972,-0.004635938,-0.042380158,-0.013422162,-0.063636504,0.063091084,0.035405077,-0.0006876499,-0.0023266997,0.036750223,0.040525712,-0.038512703,0.04054989,-0.038322423,-0.027542982,0.008149929,-0.008365813,-0.06303441,0.078912914,0.0722979,0.013840326,0.016661264,0.055765923,0.010993707,0.03559293,0.0044134487,-0.07626946,-0.018395014,-0.0028251866,-0.01715236,0.04789065,0.029078335,-0.02075241,0.047508348,-0.05547386,-0.026397107,0.016098566,-0.036029212,0.072415985,0.013971524,0.0106594525,-0.034215424,0.015623718,-0.011913119,-0.092338905,0.054342236,0.019160084,-0.0034212728,0.028479468,0.046774782,0.0061207917,-0.03190891,-0.038865827,0.05557253,0.004981424,-0.06256771,-0.05319351,0.02905038,0.0065894877,-0.0001447121,0.028832491,0.015342173,0.083887406,-0.012739612,-0.07758766,0.08184365,0.047366608,0.03989116,-0.024825172,-0.052833937,-0.02400538,-0.078844905,-0.073389076,-0.06596902,0.0026532745,-0.030274253,-0.08774896,0.0036531657,-0.10253317,-0.03335261,-0.05779115,0.10510849,0.14514971,0.0032136694,0.05138053,-0.015989315,0.0068436502,-0.06555154,0.053081524,0.05595463,-3.316256e-08,-0.025297055,-0.056223612,0.0023121682,-0.10351195,-0.08678974,0.023210943,0.065729976,0.073370844,0.053100683,0.025664194,-0.019494899,0.06731951,-0.055063363,0.017257612,0.14169133,-0.01075803,-0.046434,0.018765312,-0.04378755,-0.06001815,-0.07821947,0.049400166,-0.10148248,0.029727459,-0.08894595,-0.07895292,0.055259544,0.083174005,0.021695483,-0.045843232,0.046124354,0.06618036,0.05294785,-0.044960562,-0.10668256,-0.013903179,0.03301385,-0.015846154,0.04537625,0.054353874,-0.029970484,-0.017594082,-0.07282378,-0.0491227,-0.05445359,-0.015143785,0.009059325,0.01984201,-0.0014101724,0.014523558,0.032828715,0.072448455,0.04034323,-0.003538247,-0.054831617,-0.028959852,-0.09496389,-0.0216308,-0.010335295,-0.011257239,-0.037726972,-0.0034291209,0.18431167,-0.11024222 +2.7.8.38,Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus.,384,0.99999994,-0.093597345,-0.006873996,-0.03688624,0.0471574,0.06161068,-0.018925957,-0.06263115,0.040981114,-0.0068390756,0.0103612,0.010230346,-0.12035151,0.026617594,-0.00871549,-0.014585258,0.044284806,-0.022650769,-0.016758401,0.021343125,0.08087943,0.11843732,0.10947146,-0.04967203,-0.07650625,0.042260308,0.022268143,-0.00017214456,-0.020711381,0.027760467,-0.03306252,0.0031683603,-0.012536201,0.08763902,-0.08544602,0.117730744,0.08529652,0.023031622,-0.045561604,0.07653975,0.012960954,0.023403099,0.055437826,0.1465924,-0.068857774,-0.078184426,0.040149916,0.07206747,-0.0388849,0.024936456,-0.037429392,-0.0807908,-0.07158636,-0.052896943,0.055032052,0.034359455,0.026118284,-0.039816353,-0.015896166,0.007331066,-0.070811234,0.05574207,0.012004817,-0.0013640844,0.0012626437,0.016667174,-0.028569166,-0.06245537,-0.059918232,0.11541855,0.008180584,0.03715841,0.055620883,-0.03847796,-0.035602074,-0.095362715,-0.009672303,0.051594842,-0.04535558,0.072289385,-0.03327354,-0.0757967,-0.018095462,0.07358183,-0.037644822,0.018786967,0.04335775,0.054543912,0.035241317,-0.003734637,-0.018306796,0.0126663055,0.012840194,0.021149155,-0.030045714,-0.055955067,0.025467908,0.062544696,0.062134195,-0.020026846,0.047516212,0.032658685,0.018672453,-0.05397045,-0.051051028,-0.036012873,-0.09744872,0.01626211,0.03944406,0.035390057,0.08762905,0.07946289,-0.0029299299,0.02928161,0.031849585,0.028821277,0.002745175,0.07623801,-0.0602973,-0.017085094,0.0058012484,0.0063672755,-0.054315664,0.05208085,-0.051440876,-0.008481939,0.07995233,-0.056203097,2.00818e-33,0.092245184,-0.021798957,-0.013590675,-0.014879828,0.0687836,-0.013099344,-0.05610387,-0.03410996,0.048263997,-0.06277502,-0.11139214,-0.06421826,0.01629135,0.03750881,-0.07815149,-0.042752493,-0.04397299,-0.044652153,0.07030706,-0.0025180755,-0.032725558,0.020644369,0.009731481,0.034032274,-0.024860363,-0.013209122,0.084639296,-0.07649758,0.017159613,0.01822718,0.043150183,-0.12867238,-0.12216018,0.02839602,0.093335666,0.017602853,-0.06719718,-0.035987012,-0.049044218,-0.045293923,0.014861675,0.028367896,-0.0596187,0.0053826002,0.11340789,-0.007423125,-0.020291317,0.061762102,0.0033712452,-0.012950711,-0.031247737,0.03566761,0.018464303,-0.0057502845,-0.07382611,-0.018288609,0.028821098,0.03719341,0.051640436,0.053825743,-0.024691874,0.06444021,0.07133281,0.10540359,0.06035861,0.030299332,-0.06352101,-0.027478717,0.031790562,-0.0008370839,-0.0020622136,-0.12538737,0.0030559874,0.082322165,-0.060106058,-0.033025224,0.024366079,-0.03831963,0.02442983,-0.006371885,0.0061453967,-0.020042876,0.0012897383,-0.014998725,-0.05796639,0.0073064086,-0.018522264,-0.023205463,0.013556397,0.05051761,0.05750193,-0.0016144526,-0.08306034,0.02176954,-0.06063419,-2.7522946e-33,0.038565107,0.006804708,0.027685676,-0.07969681,-0.109022096,0.038985327,-0.06640442,-0.050789922,0.021172611,-0.053537183,0.10666999,0.042356405,0.045312285,-0.04248192,0.007083011,-0.03434439,0.049944833,0.052455377,0.029342202,0.017558135,0.030130979,0.033134636,-0.057417843,-0.032243278,-0.0072918516,0.013499065,-0.036691338,0.017413976,-0.023307195,0.03838906,0.028120162,0.038038507,-0.05934939,-0.12450783,-0.11839524,-0.025977047,-0.082282655,-0.089884765,0.04063084,0.03557748,0.062137865,0.035559453,0.024202408,0.082576506,0.017574418,-0.07886708,-0.036332566,-0.060458127,-0.030244762,0.007844704,-0.014915403,-0.101424515,-0.0410447,-0.10010674,-0.012404677,0.0032710764,0.0075707375,0.08989477,0.0029331143,-0.024325578,-0.00783164,-0.017149027,0.054323763,0.0006093653,0.05957221,0.12788224,0.029981967,0.08340447,-0.024557965,0.027763953,0.01902778,0.03906551,0.06513667,0.030027917,0.034537967,-0.021944834,-0.06994522,0.032949753,0.030758206,-0.080120824,-0.020527663,-0.004649999,0.052255332,-0.06807239,0.055830423,-0.08738901,0.07031207,-0.01715233,-0.032980233,0.0034419815,-0.020050518,-0.07259839,-0.024308963,0.028818263,0.04840268,-2.3755508e-08,-0.0015151,0.0048279655,0.027272051,-0.053662088,-0.043770354,-0.010735977,0.020605618,0.008099535,0.060648616,-0.00019578943,0.02984806,0.031054027,0.039518055,0.010303629,0.072336875,0.03129607,0.004915754,-0.024086224,-0.07620559,-0.028132237,0.00488566,-0.04581219,0.010769223,0.044053294,0.041815795,0.027828826,0.043383773,0.01831604,0.015478971,-0.016536435,-0.0050752796,0.036299895,-0.030241804,-0.07079073,-0.07560967,0.072649084,-0.037398655,-0.046988595,-0.028952727,-0.05450728,-0.053197432,0.020607853,-0.037365947,0.035579357,-0.021062074,-0.038428653,-0.07392981,0.07507366,-0.0739947,-0.009275055,0.0443541,-0.053735934,0.055549365,-0.057025265,-0.075209685,-0.010526288,0.007927262,0.015768748,-0.11330787,0.03351561,0.059173197,0.016101833,0.035654157,-0.043611847 +3.1.4.55,"Binds Mn2+ and Zn2+. Isolated from the bacterium Escherichia coli, where it participates in the degradation of methylphosphonate.",384,1.0,-0.08629475,-0.037030164,-0.040035576,0.007632181,0.040156297,0.050158598,-0.0024917275,0.0668516,0.035973925,-0.0071645956,0.036899175,0.023999134,0.06179779,0.0431175,-0.043932486,0.051971138,-0.09731196,0.008063647,-0.02371762,0.058910128,0.07608811,0.101697564,-0.040162582,-0.08767846,0.03875935,0.11965338,0.029530797,-0.03852181,0.05537547,0.032591015,-0.030249668,0.018131588,0.086066134,-0.095397465,0.05852338,0.104198255,0.08080167,-0.054587457,0.03236836,-0.027756287,0.05093427,0.062044628,0.084383294,-0.050651386,-0.012520751,0.021580085,0.04844051,-0.024022523,-0.008434873,0.034161348,-0.014695773,-0.063974515,0.021190407,0.09679373,0.027511744,0.072566845,-0.04605147,0.0071773347,-0.051073246,0.018219976,0.07262314,-0.021989793,-0.008957809,0.05064403,0.066031344,-0.0037883632,0.030465953,0.0045660925,-0.0045660627,-0.008921251,-0.029782472,-0.013037826,0.008036478,-0.004949584,-0.009659249,0.045965746,0.08917438,-0.091952994,0.013316207,-0.025119148,-0.01571814,-0.027329005,0.12232792,0.028302854,0.02209293,0.04484099,-0.008799467,0.019650932,-0.0018167153,0.06352016,-0.06417089,0.0007744878,0.068167545,-0.056891594,-0.02433689,0.04764205,-0.02305934,0.059225913,0.027387226,0.043079447,0.023437552,0.06834266,-0.08566039,-0.09773314,0.049786698,-0.026884511,-0.0029928032,0.011625345,-0.069203876,0.04318258,0.06603573,0.028903715,0.02068064,-0.008079467,0.0033192455,0.04556137,0.06714906,-0.01799622,-0.08618394,-0.021739105,-0.0004989687,-0.039063796,-0.06325557,-0.020098204,-0.06456273,0.037149932,-0.12087911,4.8600607e-34,0.06156039,-0.03428512,0.007516266,-0.023697749,0.057954874,0.027378494,-0.016840607,-0.049803555,-0.010617211,-0.07626106,-0.015947465,-0.10005246,0.046861626,0.026927616,-0.039860856,-0.013925815,-0.013303677,0.022813292,0.05131194,-0.032400396,0.039430264,0.059931252,0.015906246,-0.04016235,0.016014006,0.055772994,0.023580521,-0.03387915,0.04212355,-0.043993764,0.010736962,-0.07763113,-0.12288321,-0.02470214,0.13513632,-0.022472976,-0.06516967,-0.015817579,-0.04107498,-0.020383503,0.00222026,0.025963493,-0.1338869,0.029030653,0.044441067,-0.05502677,-0.093922965,0.046440225,0.004443732,-0.034037504,0.004661715,-0.016710687,-0.03615229,-0.0030383754,-0.07087865,-0.0047903485,0.012320642,-0.044605665,-0.04992532,0.036343995,-0.028576404,0.02237056,0.011148226,0.09117481,0.10386333,0.013113283,-0.05497791,-0.118600145,0.011436983,0.024442652,-0.006261096,-0.118392035,0.06634308,0.032473434,-0.042681593,-0.024739886,-0.06586036,-0.025715334,0.05163738,0.04612708,0.021598777,-0.043320775,0.0065165637,-0.034458097,-0.09898521,-0.054428738,-0.014552285,-0.13002054,0.03408849,0.0048503024,-0.0025984196,-0.02492538,-0.05591014,-0.0028924916,-0.053050235,-2.6781831e-33,0.04349256,0.028046073,0.07374218,-0.08965828,-0.1165845,0.07272515,-0.06125275,-0.043207858,-0.006924049,-0.026011478,0.082828864,0.026283175,0.052695155,0.032421466,-0.040209834,0.007014985,0.05460657,0.06341152,0.026938293,-0.020651972,0.084753804,0.012890332,0.025198901,0.09593316,-0.0008434084,-0.0154904425,-0.014509121,0.014298473,-0.029310603,0.061575733,-0.053980604,-0.007814232,-0.07659147,-0.14344582,-0.049958173,0.047266785,-0.055694014,-0.06865038,0.04379358,-0.0781902,0.048519336,-0.010465378,0.010744639,0.042522054,-0.01654466,-0.008386206,-0.049649138,0.0011763703,-0.06208737,-0.0072724037,-0.0028577491,-0.04043309,-0.029404268,-0.040272683,0.027832069,-0.008170919,0.018619,0.021577692,0.032398224,-0.021352882,-0.010048666,-0.030467471,-0.017179186,0.0039572017,0.011355401,0.068923965,0.07747519,0.012283498,0.0042097685,-0.035103302,0.07289818,0.08985734,0.09676263,0.031227613,-0.06224373,-0.06953307,-0.084359854,-0.06364291,-0.002074028,-0.049878642,0.03266465,0.029897658,-0.033118486,-0.036046524,0.02837386,-0.02312941,0.08335539,0.06855403,-0.03113163,-0.020654995,-0.019729486,0.005595464,-0.087376945,0.011120862,-0.0058805496,-2.5561896e-08,0.018820718,-0.08166868,0.019403372,-0.10464286,-0.09745462,0.026753131,0.0042970804,0.009158453,0.07951014,0.011606747,0.049554534,0.038927242,-0.0031717971,-0.017232247,0.029479727,0.031819858,-0.02448821,-0.016473971,-0.044820275,-0.068971716,0.0013090194,0.010686869,0.027177269,0.06459609,0.044619236,-0.033362053,0.032497097,0.07710384,0.017623765,-0.02402179,0.025042076,0.026034463,-0.004316297,-0.03795544,-0.0640786,0.04176099,0.00083937886,-0.052801233,-0.04773539,0.043894894,-0.095110826,0.06900862,-0.030599656,0.04547343,-0.047676045,-0.029360514,0.006711207,0.103548355,-0.01581936,-0.029398708,0.018410891,-0.034390293,0.04957802,-0.10717628,-0.097335,0.022646815,0.019540755,0.005400978,-0.0011091288,0.07713107,-0.039669096,-0.042202406,0.08243016,-0.046722665 +3.5.4.34,The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla [1]. tRNA editing is strictly dependent on Mg2+ [2]. 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+3.5.4.35,The enzyme from Methanopyrus kandleri specifically catalyses the deamination of cytosine at position 8 of tRNA in 30 different tRNAs. This cytosine-to-uracil editing guarantees the proper folding and functionality of the tRNAs. ,384,1.0,-0.06988389,-0.03235973,-0.026420087,-0.03690205,-0.028852982,-0.026382701,0.002009908,-0.0076552304,-0.015985996,0.066116326,0.037113782,0.04604997,-0.09611106,0.0047859433,-0.07473339,0.038140677,-0.1193333,-0.014867711,-0.014112558,-0.034895312,0.092522964,0.04769194,-0.02998205,-0.008636713,0.0064521306,-0.021598695,0.04355681,-0.023694448,-0.012961195,-0.06825949,-0.04474923,0.0070600556,0.011496652,-0.060867228,0.04767604,0.06651843,-0.11020198,-0.014356308,0.11474762,-0.010908553,0.083020866,0.008643995,0.012363634,-0.020582052,-0.017233707,-0.04248759,0.053776458,0.031795446,0.0034587516,-0.043798354,-0.021437768,0.010501258,-0.00583789,0.03269939,-0.047667883,0.07692821,-0.07697541,0.010069897,0.023081144,-0.038122967,0.04142847,0.005209507,-0.004996755,-0.06406464,0.0920709,-0.0749015,0.067166895,-0.041482266,0.035571042,0.043545693,0.014239337,0.03268418,-0.050947964,0.013750868,0.015757708,0.003965015,0.022907006,-0.08575599,-0.041663986,0.02988477,-0.0019745787,-0.009398868,0.078219496,0.046722043,-0.0118394075,0.00953933,-0.024013104,-0.0010911513,0.03581955,0.04388497,0.066363975,0.040338352,-0.0060390127,-0.010460003,-0.12102992,-0.026993288,0.10275886,0.088276535,0.04333305,0.00277901,0.009402461,0.040674,-0.060924448,-0.0831147,-0.060229767,-0.026880266,0.07707463,-0.033398617,-0.014985901,0.016404597,-0.0021247983,0.007409947,0.06750592,0.048198722,-0.04824919,0.075303964,0.04244915,0.011314436,0.009318069,-0.006616071,-0.017119538,0.025556697,0.054701515,0.0894885,-0.1105453,0.07797616,-0.11424321,3.101476e-33,-0.033773128,0.0071627027,0.01835542,0.024282385,0.07617665,-0.08028281,-0.06552233,-0.056366123,-0.06633004,-0.00652098,-0.1156188,0.0025114338,0.011376459,-0.032467768,-0.026783017,-0.04423143,-0.04122469,0.038747188,-0.018256875,-0.05132876,-0.012759711,0.07458343,-0.034446348,-0.03533779,0.033400528,-0.0016518105,0.008154334,0.04326299,0.04119741,0.00039184935,0.043001406,-0.028471258,-0.09531592,-0.017754309,0.12165575,0.0133396825,-0.030426586,-0.006445099,-0.07117819,0.012475215,-0.012901871,0.0067552323,-0.015653085,-0.007551451,-0.024094773,-0.03623635,-0.04613192,0.06276086,-0.03816684,-0.009153813,0.014701394,-0.008181847,0.041410502,-0.021136364,-0.055288643,-0.029793413,0.034450173,-0.11580844,0.13222016,0.12507196,-0.008947772,0.011945373,-0.06544676,0.0396295,-0.057501715,0.041605935,-0.042477816,-0.047676865,0.015498672,0.06545592,-0.09843198,0.017871981,0.050918885,0.010923112,0.000745824,-0.016590714,-0.019850403,-0.029207299,-0.057023935,0.011927384,0.029162806,-0.0467479,0.010299734,-0.029038489,0.016201504,-0.025351804,-0.026718708,-0.03229911,-0.016469993,0.10261578,0.032145087,-0.034811646,-0.027393082,-0.044679668,0.016002273,-3.9046737e-33,0.057647284,-0.054321248,0.02201332,-0.08068413,-0.08461712,0.04402003,0.018044192,-0.06441419,0.015124301,-0.10344239,0.05735903,0.0321018,-0.005023846,0.0064973887,0.05294285,-0.019449012,0.052483696,0.0064747124,-0.038193233,-0.048273213,0.0005165406,0.014948853,-0.037159454,0.008656505,-0.020224685,-0.03267494,-0.017736703,0.112582624,0.033765998,0.03733276,-0.036593664,-0.08984529,-0.00033692832,0.04869534,-0.10124105,0.04418896,-0.04818968,0.007082094,0.090024084,-0.02339778,0.03643482,0.025216429,-0.020085335,0.09690533,-0.0020973983,0.08135034,-0.10107963,0.021070886,-0.09397253,-0.032956135,0.1080466,0.012677246,0.009637408,-0.058720093,0.09970226,0.055309493,0.009590639,-0.022544771,0.032689646,0.028587226,0.01983524,-0.035357695,-0.0076855337,-0.0060357274,0.050837904,0.026378103,0.020876741,0.08934842,-0.037131462,-0.030603329,0.019469922,0.034013376,0.018935096,-0.016385127,-0.007529429,-0.018332424,-0.08008771,0.02483424,0.08268612,-0.081016466,0.013029144,-0.026159083,0.014040145,-0.050114445,0.043115914,-0.023352558,0.042378347,0.14182375,0.034651596,0.1019297,0.039276686,-0.057184268,0.05408867,0.066089235,0.04821157,-3.1621855e-08,0.010019213,-0.08271212,-0.016852463,-0.007240622,-0.024494786,0.05903156,0.029606614,0.06273837,0.076046474,-0.056968763,0.013518774,0.03197811,-0.019617245,0.08281033,0.014914132,0.026642876,-0.08428769,0.056484316,-0.011442706,0.005316439,-0.08321208,0.067797504,-0.16034114,0.08983036,0.029060591,-0.015679883,-0.01003279,0.08939736,-0.08402978,-0.06023304,0.023855796,-0.0018613896,0.032554228,0.030115278,-0.066961706,0.026005533,-0.06446566,-0.01885656,-0.0574561,0.017154507,0.003836658,0.046522647,-0.06435064,-0.025319383,-0.06717329,-0.01977866,0.0036862583,0.0474196,-0.029230172,0.05582396,0.045296825,0.024545304,0.07122058,-0.02801527,-0.07768728,-0.01810688,-0.0013274043,-0.049084242,-0.10544129,0.028854642,0.074989974,0.02448934,0.087185085,-0.02727747 +3.5.4.36,"The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site [3]. 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+3.6.1.64,"The human enzyme also hydrolyses GDP and dGDP, and to a lesser extent ITP, dITP and XTP.",384,1.0,-0.031647652,-0.025149917,0.061541036,-0.02592302,0.03081475,-0.05531548,0.033901457,0.14232637,-0.017555373,-7.0153845e-05,-0.0029546814,0.0110444855,-0.0976462,0.051300213,-0.020679545,-0.025981057,-0.013628118,-0.0303567,0.028391454,0.0050565368,0.077335924,-0.0070750997,-0.063442566,-0.05203445,0.032032438,0.020395188,0.076493144,-0.042452823,0.0023607628,-0.01394391,-0.020315213,-0.00048955955,0.03463651,0.002083628,-0.0037050531,0.13025407,0.030069228,-0.039267402,-0.046368472,-0.061421268,0.0840843,-0.044978578,-0.026274033,-0.028256126,-0.040855654,0.013888859,-0.07375962,-0.0032955895,-0.10590036,0.012603356,0.029549144,0.01805428,0.029461829,0.014098461,0.035340708,-0.047878236,-0.026643068,0.028242914,-0.070496455,0.013823166,-0.059986446,0.04416698,-0.0006892784,-0.006172541,0.1450402,-0.0040046875,0.03896219,-0.023611825,-0.039074507,-0.03831541,-0.07774907,-0.04801901,-0.037184153,0.025856126,-0.014098013,-0.018683128,-0.014514056,-0.064706154,0.05416055,-0.07222892,0.06891405,0.103999734,0.038528908,0.04201144,0.032838788,0.012263297,-0.03331005,0.061458234,-0.08016153,0.0048313946,-0.0043360814,-0.013168919,-0.057699837,0.017449485,-0.030688038,0.041110314,-0.032612838,-0.024495881,-0.022303274,-0.04054998,-0.034953307,0.080360115,-0.0651857,-0.038802072,-0.04319867,0.0031618418,0.012982341,0.024498623,0.03168536,0.015713548,-0.0017298628,0.022388652,0.028405273,0.07227403,0.044236295,-0.0005378226,-0.050283145,-0.018424476,0.0048709726,-0.010034526,-0.019958647,-0.08844057,0.02847793,0.094721094,-0.0014143306,0.018523293,0.0050121187,-3.2866043e-33,-0.00082717265,-0.020311072,-0.0038199709,-0.07072383,-0.007493612,0.048451807,-0.010656249,0.046839394,0.0088082785,0.021820791,-0.09322224,-0.03597131,0.0030663935,0.04934437,-0.055426512,-0.060096875,-0.02048088,0.0890793,0.072369926,0.019816112,0.07415026,0.0069669858,-0.033809092,-0.0044761784,0.04824233,0.03652179,-0.097044215,0.037972573,0.101167545,-0.02045523,-0.031686325,-0.1137273,-0.04286477,0.091222286,-0.06281518,0.072451405,-0.035163328,-0.053272344,-0.0150526585,0.055793453,0.029844966,-0.0251646,0.00082072685,-0.051445458,-0.017798001,0.02632761,-0.044781204,-0.088387094,-0.0547657,-0.06256008,0.013470731,0.007138644,0.025217459,-0.08764626,-0.03325827,-0.005306298,-0.07843705,-0.02961423,0.054120827,0.101608425,-0.013978765,0.08492507,-0.062101975,0.010136958,0.03917876,0.00010229822,-0.020637834,-0.099641934,0.0038176558,0.12388649,-0.07860999,-0.023389708,0.13300039,-0.0226306,0.0342598,-0.043605864,0.021895679,0.07675705,-0.027640268,0.049355067,-0.026052639,-0.04624544,0.009523923,-0.008276011,0.020194715,0.03062677,0.011120295,0.0048380382,-0.040545836,0.024191942,0.036226604,-0.06883529,-0.039975595,-0.0044011446,0.008590168,-1.5414846e-34,-0.046587233,-0.008438027,-0.015247684,-0.024639608,0.056425635,0.0912969,0.12119523,0.0020187348,0.047399633,-0.032304898,0.10806245,-0.061790384,-0.04168858,-0.078904934,0.013997246,0.046507448,-0.024240818,0.026060145,0.006245833,-0.018002104,-0.075054266,0.08985521,0.035192445,0.10040239,0.05823722,0.0088812895,-0.041420136,0.030795919,0.06398063,0.03889689,0.03602978,0.10783308,-0.09527522,-0.04095549,-0.01112902,-0.022683484,-0.13751867,0.022546666,-0.008667309,0.03452413,0.015112091,0.057259798,0.026557984,0.0603697,0.041529745,0.11044324,-0.06378286,-0.029796273,0.030248206,0.0011710918,0.11337415,0.044606652,-0.058945797,0.019515853,-0.01869788,0.049324367,0.10236347,-0.0034525744,-0.03401791,0.0036891757,-0.06295607,-0.07664652,0.021119447,0.043509606,-0.049903728,0.00921343,0.012577357,-0.009944929,0.0502606,-0.018461378,0.04128435,-0.058548886,0.00047863062,-0.019653156,-0.02942558,0.028116893,-0.071255594,0.02006655,0.057357363,-0.015861498,0.00026968826,0.04973186,-0.032509517,-0.07235354,-0.0025271974,-0.08931115,-0.020529874,0.056567125,0.0044455263,0.0498833,-0.1097975,-0.009912665,-0.11367878,-0.022452837,0.025800448,-2.5274312e-08,0.04272632,-0.10702647,0.07653409,0.012043919,-0.015375191,0.006777419,0.047749836,0.080971785,0.055445325,-0.012060386,-0.027581325,0.037940457,-0.07608009,-0.01828571,0.07880522,-0.0059854537,-0.013273614,0.024120437,-0.05376693,-0.057665467,-0.0205626,-0.011127235,-0.118998714,0.019265018,0.019368477,0.001559451,0.047007672,0.0056648743,0.04773616,-0.048757095,0.011295172,-0.0075292676,-0.034627378,0.01576211,-0.0004935771,0.027059052,0.020795863,-0.042062648,-0.07502927,0.030266812,0.0002763413,-0.08163619,-0.013070479,0.022160947,0.007163864,0.0036259214,0.04850569,-0.0063135116,0.027128423,-0.051201593,0.051276088,-0.035471655,-0.013352973,-0.09438602,-0.016133633,0.02043244,-0.019361665,-0.08235553,-0.047198445,-0.102488205,0.009916996,0.025810845,0.19667412,-0.024298586 +4.1.3.42,"The enzyme from the bacterium Escherichia coli, which is specific for the (S)-enantiomer, is trifunctional, and also catalyses the reaction of EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase, and the beta-decarboxylation of oxaloacetate. cf. EC 4.1.3.16, 4-hydroxy-2-oxoglutarate aldolase.",384,0.99999994,-0.016579349,-0.015638676,-0.02742191,-0.02041954,0.003742673,0.049226157,-0.08428693,0.016319195,0.02378406,-0.0038970464,0.026008135,-0.092701584,-0.063285805,0.03217522,-0.036870204,0.030603854,-0.035282567,0.014738785,0.042084564,-0.053805083,0.06779361,-0.0008072696,-0.051505435,0.056554433,0.044365272,0.051237766,0.05772489,0.0061756787,-0.093752086,-0.10683707,-0.012102391,-0.07481758,0.07301369,-0.06447685,0.049052503,0.08983982,-0.038994774,-0.1314724,0.08944287,0.06713857,-0.020789308,-0.003369949,-0.009166198,0.0023408583,0.025943035,-0.030217147,0.012075008,0.03149303,0.052373897,-0.036803383,-0.012624824,-0.02362475,-0.04588303,-0.0133911325,0.06558947,0.010493265,0.015374288,-0.039451312,-0.04496322,0.033472467,0.11831158,0.0048178793,-0.011317603,0.04271856,-0.0028074184,-0.023499759,0.07100646,-0.09420829,-0.010321345,-0.048550908,-0.03546335,-0.09232894,-0.025248324,0.027592456,0.00060350366,-0.032699857,-0.007339019,-0.0503442,0.008133225,0.0379303,0.083128884,0.006143891,-0.0012070854,-0.02213577,0.034552276,-0.00691665,-0.029409476,-0.039637648,0.047408443,0.030966656,-0.003713182,-0.062538184,0.0015659968,-0.029375577,0.033771288,0.018989095,-0.030651832,0.07874452,0.032460727,-0.050419085,0.001552409,0.077123836,-0.013174684,-0.07946999,0.045410268,0.028934028,0.057993397,0.14567307,-0.0141001735,0.01704369,-0.027159415,-0.054427758,0.10268452,0.027412778,-0.008183973,0.11518471,0.040681247,-0.039463613,-0.0068030977,-0.029149361,0.07357136,-0.07403355,0.032494843,0.015567974,-0.039755095,0.05427318,-0.1293398,2.9240268e-34,0.13368131,0.020439722,0.0353459,0.009669447,0.003894797,0.004013893,-0.03919652,0.048148066,-0.1160183,-0.02671187,-0.0865052,-0.0040304675,0.06488978,0.05695816,-0.011084642,-0.02404846,-0.06797905,0.025667822,0.03480012,0.015078349,-0.011565595,0.031443376,-0.04921548,0.04792857,-0.005443572,0.03892878,0.009956292,-0.001795192,-0.011097659,-0.03433436,-0.0052935844,-0.024442729,-0.10160263,-0.017979858,0.020381398,-0.092141494,-0.018389499,0.03002548,0.013735508,0.062177014,0.04266206,0.053604208,-0.002817811,-0.04594777,0.075977765,-0.016119648,-0.06621537,0.073976755,0.062836826,0.0625737,0.060574472,-0.016866768,0.059800435,-0.023806617,-0.013356,0.035743278,-0.0348712,0.04180041,0.042424634,0.03610212,-0.01606199,0.07922304,0.03153798,-0.018019611,0.009417488,0.0013447299,-0.049155653,-0.031877708,-0.038694624,0.05608283,-0.05705387,-0.0033001911,0.059563566,-0.00072948984,0.052657872,-0.08769327,-0.11324884,-0.015198973,-0.0013609615,-0.011740381,0.021539748,0.03442891,0.022859666,0.051794887,-0.012290101,-0.011492535,-0.012635196,0.02135782,0.024151208,0.10370627,-0.013821424,-0.009975664,-0.10136356,0.061165202,0.03224685,-1.4959318e-33,0.12140869,-0.13263445,0.035632465,-0.063238814,-0.085459895,0.07538041,0.010216626,-0.032982167,0.059598915,0.061102115,0.09655005,0.030486925,0.08463905,-0.09270553,0.047085542,-0.047478102,-0.07379139,-0.00843907,-0.08574458,-0.02117072,0.06903886,0.03914962,-0.012103309,-0.05144982,0.0738146,-0.0015860369,-0.02014816,0.034220677,0.0535951,0.01569252,-0.041769434,-0.05084612,-0.024580285,0.0015445765,-0.086792886,0.092720374,-0.05160503,0.02858443,0.018342072,0.021850549,-0.020294653,0.035096977,0.017683167,0.0875793,0.063386135,0.031022683,-0.0044050785,-0.030381093,0.013119432,-0.008497548,-0.010953128,-0.05519969,-0.06624577,-0.0067932787,-0.0072696833,0.04685585,-0.038778782,-0.010612924,-0.014384187,-0.006285846,-0.050653864,-0.018218352,0.10581349,-0.06865915,0.007191578,0.023568988,-0.07264299,0.011586543,0.05044695,-0.024435751,0.09371978,-0.009097933,-0.042742718,0.051798705,0.0596084,-0.022974592,-0.13305545,-0.06894315,-0.036328092,-0.015543844,0.0035959487,0.0054520546,0.012001915,-0.025077399,-0.014678274,-0.0926482,0.0741587,0.08735555,-0.059251074,0.030194027,0.00410904,-0.024249258,-0.04061966,0.07181755,0.048751045,-4.2763496e-08,-0.013087435,-0.008796431,0.049755976,-0.035822332,-0.01819871,0.07225913,0.08768713,0.019330135,0.071908854,-0.08384039,0.020023022,0.061762575,0.012317281,0.025336659,0.08045678,-0.048620075,-0.02916091,-0.00235878,-0.020193988,0.0039952355,0.029696887,-0.032986682,-0.07697506,-0.013185918,-0.004164772,-0.043055326,0.03441716,0.0340679,-0.045259893,0.0032732533,-0.019089013,0.0008893417,0.017082747,-0.03340327,-0.037301112,-0.052097034,-0.06738552,-0.020729627,-0.023586908,-0.050832294,-0.005903285,-0.11175355,-0.105770655,0.03453782,0.0032976258,0.039309796,-0.0005622646,0.010970622,-0.0171681,-0.0055414606,0.08818037,-0.064682506,-0.008921392,-0.027049642,-0.08389157,0.03567418,0.0011708809,-0.0744061,0.028814482,-0.05641925,0.017715055,0.0031010923,0.17330194,-0.030808853 +4.2.3.141,"Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141, sclareol synthase. Sclareol is used in perfumery.",384,0.99999994,-0.03980274,-0.044276837,-0.10542796,0.036580786,0.13790625,0.12936243,-0.06937478,0.0321484,0.033421017,-0.056372028,0.05085053,0.004873964,-0.08312863,-0.022388238,-0.02762142,0.03255432,3.0749175e-06,-0.009975778,0.006300125,-0.046777032,0.13965127,-0.00038811404,-0.00432358,0.043091547,0.041739956,0.013600396,0.0044880384,-0.028009651,-0.0019273836,-0.081054375,0.044884067,-0.0066880053,0.08560411,-0.08537891,-0.004765725,0.030350752,-0.0280847,-0.047609985,0.065584116,0.022643864,-0.028747736,-0.04301313,-0.07023269,-0.016171975,-0.069890864,-0.07788408,0.017672148,0.027677117,0.07129684,-0.047151376,-0.07792842,-0.08807342,-0.0005953661,-0.0007143101,-0.013696381,0.0052724406,-0.04161418,0.0018049356,0.025141997,0.06052665,0.039152488,0.02230627,-0.012478384,-0.05904677,0.016198937,0.0073384037,0.004290667,-0.0648712,0.0894778,-0.04836434,-0.07076239,-0.06986901,0.017723283,0.107910134,-0.011954202,0.050096173,-0.041533913,-0.024471384,0.018541545,-0.02069673,0.008533887,0.029203061,-0.09171988,0.046331957,0.06611973,0.0523834,-0.038027763,0.020167938,0.08977443,-0.06515654,0.036661725,0.025416695,-0.062027812,-0.046831522,-0.006997704,0.078355566,-0.017015256,0.059124418,0.039158847,-0.007947925,0.06321111,0.051720925,-0.057782795,-0.10132743,-0.0474028,0.054435015,-0.03323739,0.009669949,-0.01961218,-0.013614202,-0.009217679,-0.03102754,0.0067147054,-0.060243778,-0.015748316,0.03336832,0.0038053882,-0.06477681,-0.05842931,0.022336466,0.05689458,-0.032202177,0.033373244,0.057151854,0.015397176,0.05025325,-0.05479965,4.1635738e-33,0.050860535,0.08014282,0.01636348,0.060113676,-0.06160075,-0.034631968,-0.012671921,0.10045127,-0.08442666,-0.06755612,-0.027334053,-0.073932916,-0.050750688,0.0209248,0.014266085,-0.025158625,0.09588978,-0.023954218,0.104293644,-0.034537848,-0.063155584,0.061299536,-0.04230557,0.008636459,-0.09070946,0.017298687,-0.0016025209,-0.008393011,0.10323069,-0.0063065295,0.086334795,-0.01722795,-0.04362048,0.029969472,-0.016113019,-0.017977407,-0.05420746,-0.03429018,0.019132687,0.07154679,0.07694184,0.086781636,0.12021746,0.020986564,0.043670632,0.023375185,-0.101824544,0.041089986,0.13788259,-0.044930995,0.013377736,0.03773403,0.06461842,0.03864987,-0.014128826,0.020631822,-0.030454349,-0.027573586,0.033692118,0.04805201,-0.05689224,0.061562214,-0.031128844,0.0066801338,0.017818984,0.032866452,-0.11435771,-0.01455195,-0.007996555,0.041048013,-0.005618489,0.05116944,-0.03480332,0.055936914,0.0031999717,-0.06801336,-0.015549973,0.056119926,0.026945844,-0.013195373,-0.044216953,0.012904824,-0.0014727907,0.12357798,-0.075140424,-0.0623928,-0.0807048,0.046608783,-0.016128689,0.038430184,-0.006215643,-0.045831084,-0.075386345,0.016743584,-0.049156886,-3.4687057e-33,0.05318443,-0.032259632,0.038690213,-0.018206958,-0.107358836,0.10850795,-0.035277423,-0.028948847,-0.01816968,0.060351066,0.08865712,-0.05421846,0.10772399,-0.08976384,-0.0279901,0.07679559,-0.0030818938,0.023883551,-0.020139301,-0.0010926746,-0.054111816,0.090116724,0.072094336,-0.0019899034,0.031392567,-0.0011481208,0.06482177,0.013279898,0.0054939548,0.047189035,0.050734255,-0.01999478,-0.081806,-0.05911539,-0.08474278,-0.034607414,-0.0852519,0.0024417168,0.0021728247,0.038811106,-0.0278158,0.06994783,0.024428634,0.002743705,0.061829943,0.039400328,-0.037761576,0.010466092,-0.009069905,-0.04714884,0.047559686,-0.008386062,-0.03315,-0.07695293,0.02351929,0.004623532,-0.029928636,-0.009860716,0.029002493,-0.094239995,0.017021269,0.03348221,-0.055431817,-0.054193795,0.04588853,0.06516324,-0.053016365,0.07346531,-0.047922574,-0.0009700335,0.07360666,-0.01598147,0.061884724,0.07274047,-0.010135472,0.028570402,-0.04255323,-0.026743595,-0.02259459,-0.002484503,0.025490675,-0.05474743,0.010375409,-0.07774606,0.0008452139,-0.021619653,0.014585205,0.03955935,0.033357825,0.04557167,-0.081522115,0.034295786,-0.056502726,0.059741657,0.13305709,-3.7418456e-08,0.010486308,-0.03724287,0.028258096,-0.026412135,-0.022217516,0.015554782,0.03383689,-0.01247154,0.035181902,0.018637858,-0.14654638,0.016649786,0.048105776,0.033740107,-0.004467545,0.008671314,0.06917327,0.08597392,-0.010393864,-0.027612634,-0.007922641,0.014502182,-0.033578143,0.00069508684,0.004611711,-0.107611455,0.0814325,0.008066577,0.044505388,-0.0068917517,-0.0127200615,0.0022786884,0.014424801,0.0049969316,-0.006744725,0.06204581,-0.0708544,-0.04402868,-0.04056407,0.0070791095,-0.0035010974,-0.067970514,-0.054464433,-0.013317403,0.014496478,-0.06949268,0.027746275,0.019080214,0.020054718,0.020699905,-0.012489849,-0.021381844,0.015225149,-0.033244684,-0.03149791,-0.06505955,-0.0046995436,-0.058871567,-0.00879903,-0.1000366,0.02414676,0.007436296,0.07001312,0.052498963 +4.2.3.142,Isolated from the plant Solanum habrochaites. 7-Epizingiberene is a whitefly repellant.,384,0.99999994,0.015294942,0.049523268,-0.11777353,0.002101934,0.12313714,0.08554944,0.030130882,0.00856834,-0.04200969,0.017095726,0.09713145,-0.058035225,-0.06275297,-0.03761834,-0.052090574,0.034660973,0.01898957,0.028052915,-0.04665049,0.017870301,0.014711732,0.04210224,0.012876058,0.03579388,0.042305645,0.011295641,-0.026592357,0.032106247,0.027896296,-0.11703265,-0.015782539,-0.0012233262,0.021196388,0.026057122,0.012721072,0.054337338,-0.03543715,-0.01677788,0.013782059,-0.018214997,0.055125844,0.018081201,-0.024241216,-0.005858561,-0.047777776,0.01656504,-0.015682094,0.014030322,0.039976384,-0.05203433,0.06092566,-0.060029157,-0.027078351,0.09391681,0.036931667,-0.04069503,-0.016740033,0.040816106,0.05183655,-0.0030936406,-0.0032200515,0.0075928955,0.01345309,-0.030931983,-0.016527211,-0.038540345,-0.06127557,-0.019695738,0.08926794,-0.09918381,0.06812137,-0.034181803,0.03467412,0.088197984,-0.08506734,0.08705509,-0.036087457,0.025638064,0.0458083,0.0313175,0.056591246,-0.0017039113,0.057900943,0.04562383,0.031717375,0.05405304,-0.0039999806,0.08259692,0.047567908,0.050688613,0.009391966,0.050506722,-0.0042218105,0.00055870373,-0.0711673,0.03361314,0.010705289,-0.026833853,-0.006868505,0.064069614,-0.0010442648,0.0154971285,0.035036765,-0.08621592,-0.10620053,-0.031681024,0.06554589,-0.035119478,0.0036323292,-0.005332044,-0.04101896,0.0017585885,-0.006155653,-0.015587573,-0.07955116,-0.04810063,0.027337233,-0.050684046,0.004999294,-0.030661546,0.015416676,0.012043653,0.07126636,-0.0051518907,0.034871273,-0.070459016,-0.053493455,7.6108034e-34,0.0337835,-0.039980877,-0.016175626,0.015865656,0.045713097,-0.045422547,-0.043010913,0.022916974,-0.014973155,-0.11518303,-0.061513804,-0.086033754,0.0015017313,0.0051988433,-0.022508005,-0.052184206,-0.0010888994,0.008939502,0.07451701,-0.110562146,-0.07507597,0.032742497,-0.08724734,0.011594978,-0.012098326,-0.011400694,-0.0209277,-0.032994732,0.10467994,-0.0028291612,0.1160914,-0.03905691,-0.044125732,0.05947779,0.0023461918,0.11824141,-0.094686426,-0.03562295,-0.09245706,0.047562853,0.022235656,0.0120974975,0.026959522,0.0006956181,0.07613767,-0.09444509,-0.05416223,0.011539659,0.07678931,-0.06038154,0.01420709,0.034318186,0.089039214,-0.03183619,-0.03275757,0.038485948,0.051122107,-0.00016168125,0.03173079,0.024123373,-0.012710352,0.10063125,-0.048155796,-0.021734975,0.07694833,0.07354192,-0.18781881,-0.008204957,-0.03317755,-0.037628938,0.04371573,-0.114923246,0.085355565,-0.036433395,-0.032256965,0.024657713,-0.0028952442,-0.0144240055,-0.048334595,-0.0129189715,-0.03488858,-0.06170347,0.038645204,0.08283579,-0.09495801,-0.001913319,-0.042631432,-0.028247686,-0.007208293,0.050785396,0.091508515,0.015600475,-0.03604859,0.0037765396,-0.003123873,-8.611059e-34,0.042777177,0.03119795,0.014424526,-0.008983886,-0.011562025,0.15201621,-0.0638641,-0.003229645,-0.07579316,0.0036641238,-0.008655542,-0.016873462,0.03217491,-0.022528995,-0.015534087,0.07683066,0.0398577,0.12894808,0.0128105655,-0.029317442,-0.113445446,0.06580665,0.04869839,0.014920573,0.018944088,-0.030561185,0.12109559,0.023329895,0.012995968,-0.023273265,-0.011006655,-0.07710939,-0.04465001,0.019372163,-0.050926983,-0.037042383,-0.017764954,-0.098429255,-0.028888596,0.0022989486,-0.09352716,0.014192007,-0.025583105,-0.023931395,0.046685725,0.03550341,-0.006906268,0.05914164,0.021883814,0.012440197,0.040930584,0.058202546,-0.050889146,-0.015846694,0.008634623,0.00022384668,0.03631874,0.02426097,0.036283404,-0.054873705,0.03211502,-0.056362282,-0.06774584,0.034858365,0.06632599,0.061883908,-0.031593706,0.10835755,-0.042935453,-0.03529419,0.031546474,-0.029968102,0.04054664,0.04581015,0.015320277,-0.034246117,0.08377411,-0.03956222,0.021361863,-0.033041522,0.031798564,-0.033603683,-0.01589605,-0.016939072,0.04131752,-0.02893388,0.0071033253,0.0031486137,-0.019497233,0.050098676,-0.0016856038,0.027359873,0.0044425507,0.076654345,0.13791017,-2.1671536e-08,0.04234304,-0.05632565,0.008872672,-0.042981252,0.014911543,-0.03702869,0.05359647,-0.025331605,0.004371336,-0.014980143,-0.038015217,-0.037053023,0.05614189,0.027522713,0.12277856,-0.057172403,0.061928257,0.059383705,-0.06581146,-0.0028124426,-0.119176656,0.01650788,-0.035542954,-0.030716738,-0.030019015,-0.03703813,0.05220266,0.017593758,-0.031421855,0.020965565,-0.025362335,0.07202147,-0.037621368,-0.10162723,-0.08557298,0.099656604,0.016279802,-0.027757702,-0.03464699,0.020713408,-0.055213146,0.020323703,0.047580346,0.0021169863,-0.015296142,-0.030258726,0.010025341,0.054746963,-0.04950895,-0.039551858,0.1030738,0.014942636,0.037714895,-0.08001114,-0.07037469,-0.06261202,-0.0053138747,-0.047994737,0.010756608,-0.029182294,0.015802134,-0.032793436,0.05787603,0.04644505 +4.3.99.4,The enzyme utilizes a glycine radical to break the C-N bond in choline. Found in choline-degrading anaerobic bacteria.,384,1.0,-0.074847475,-0.08573095,-0.061301906,0.013137599,-0.027410898,0.020816272,-0.108224355,0.052298795,-0.016765015,-0.002159358,0.03934129,0.015096743,-0.0740215,0.048036695,-0.06968991,0.08850502,-0.024897885,-0.052087445,-0.014963473,-0.006213634,-0.016566306,0.007824,-0.019241747,0.0075830775,0.06675466,-0.0065958956,0.08761,-0.025759634,-0.033608664,-0.03151603,0.010054264,-0.022190427,0.16186288,-0.034926854,0.0377115,0.064869426,-0.011329022,-0.00798227,0.117513716,-0.010261,-0.01588901,0.055027638,-0.0044440557,-0.0149239935,0.08596036,-0.015245888,0.015698215,-0.012978507,0.069895014,0.025511319,-0.05421609,0.017409448,-0.05681912,0.0054606926,0.020958614,0.03476742,-0.08671921,-0.07816288,0.03651094,0.0023693668,0.04898359,0.044602156,0.049169764,-0.046475533,-0.020157693,-0.08144228,0.109356314,-0.044705458,0.0680692,-0.016496643,-0.05272471,-0.09862542,-0.027274076,-0.06133621,-0.017248096,0.022829965,-0.047984518,-0.052708585,0.06716427,-0.07095213,-0.010255588,-0.030150231,0.022843307,0.0811105,0.05746102,0.051351488,0.038108394,-0.017249739,0.053776946,-0.004301408,-0.012564135,0.022166787,0.021118775,-0.031461477,-0.0810622,-0.055424023,0.029958978,0.054832377,-0.041477367,-0.027199887,0.04905478,0.08457314,-0.00026154483,-0.12157336,-0.052028555,-0.021929078,0.05883214,0.0938549,0.060462315,0.013621145,-0.014992507,0.07781543,0.017363355,-0.06622636,-0.008557148,0.12809719,0.008195314,0.002808871,-0.0072629913,0.10996606,0.026081067,-0.035390045,-0.038315475,0.0649844,-0.07045002,0.04339778,-0.011816359,-3.2937891e-34,0.060085814,0.0074617695,0.019620145,-0.04617671,0.047279567,-0.059333175,-0.12830997,-0.016506936,0.016245913,-0.039192885,0.01766302,-0.08004409,0.0623182,0.013791588,-0.026642978,0.02104907,-0.02780802,-0.056787714,0.01759135,0.0072680735,-0.048581246,0.05741189,0.005950576,-0.013514791,0.07760965,-0.027187025,0.032139085,0.028729297,0.020294162,0.013484284,0.033523638,-0.1230399,-0.07188927,-0.007764364,0.005105991,0.034927733,-0.06467042,-0.040431503,-0.042232912,0.05337287,-6.449361e-05,0.03361038,0.0022378298,0.04767803,0.028466124,-0.030188909,-0.034054697,0.122277796,-0.022675475,0.010779361,0.046968117,-0.058727663,0.07629215,0.025730325,0.0025570777,0.047137704,0.03770749,0.01546242,0.043412767,0.05590664,0.05006681,0.030949827,-0.0753459,0.0458215,-0.0016983263,-0.009952143,-0.10111567,0.008802264,0.0066829748,0.018612882,-0.10671601,-0.06099983,0.027963312,0.039236404,-0.0816413,-0.053879797,-0.040218268,0.041757457,0.018886255,-0.07772226,-0.020294184,-0.010512737,0.013297706,-0.041698914,-0.06088217,0.011598055,-0.030062456,-0.068647005,0.00064200826,-0.0143551575,0.061961,-0.04837502,-0.07914671,0.020377353,-0.0003208194,-8.288282e-34,0.0604171,-0.097435944,0.006423894,-0.02235399,-0.07564937,0.07243459,-0.035952814,-0.035377227,0.024633758,-0.06062385,0.02675297,0.0096957665,0.009636318,-0.009960715,0.08856275,0.04253908,0.038779408,0.057765137,-0.054569386,-0.01939794,-0.047242053,0.033484526,0.026877789,0.001031346,0.019283202,0.04469618,-0.0062830113,0.053374007,0.08232522,0.030926045,-0.012186303,-0.016662175,-0.06086093,-0.06341908,-0.01828345,0.07589053,0.0022860074,0.0015206673,-0.017091064,-0.04017128,0.029378878,0.02698944,0.0068204235,0.07804535,0.012458167,0.074476585,-0.034080636,0.010035327,-0.056485534,-0.02587771,0.06766369,-0.05808104,-0.018231168,0.00034505737,0.054325953,0.10388862,0.0064134146,0.016909085,-0.013510272,-0.07466671,-0.05496636,0.013931057,0.046418913,0.015125967,0.030229187,0.022720644,-0.022279935,0.05515994,0.03185725,-0.061004356,0.006752947,0.11735874,-0.013437734,0.041448787,-0.09238088,0.06685261,-0.067573816,-0.05709435,0.0007068626,-0.027021775,0.026455663,-0.037084498,0.0043454403,-0.023366157,-0.011350696,-0.040526472,0.015633184,0.14025214,0.05791852,0.000826395,0.022694655,-0.06839452,-0.10658769,0.052484103,0.035656147,-2.3232149e-08,0.041703288,-0.04910018,0.020932209,-0.039703127,0.026168741,0.033646088,-0.013531038,-0.0063193473,0.03098734,-0.044066742,-0.049027707,0.13823742,-0.048247475,0.011836043,-0.082577266,0.07390321,-0.023851693,-0.0035009154,-0.03560103,0.02779822,-0.13590571,0.0004636028,-0.05385017,0.08185147,-0.009961036,-0.061686207,0.032427963,0.088441536,-0.042907666,-0.052625064,0.025593016,0.030568447,0.023171566,-0.061743826,-0.061281446,-0.032250084,-0.0048363847,-0.07413215,0.014486245,0.09976001,0.03868464,-0.004584579,-0.0783793,-0.009860336,0.016812539,0.010686044,-0.012856393,0.029351922,-0.089150056,0.0021182266,0.009545768,-0.008783715,-0.013030155,-0.028530875,-0.10043542,0.0019435312,0.006776289,-0.043810353,0.038233478,-0.034414213,-0.06055233,-0.021309542,0.15443206,-0.0024012174 +4.7.1.1,"This radical SAM (AdoMet) enzyme is part of the C-P lyase complex, which is responsible for processing phophonates into usable phosphate. Contains an [4Fe-4S] cluster. The enzyme from the bacterium Escherichia coli can act on additional alpha-D-ribose phosphonate substrates with different substituents attached to the phosphonate phosphorus (e.g. alpha-D-ribose-1-[N-(phosphonomethyl)glycine]-5-phosphate and alpha-D-ribose-1-(2-N-acetamidomethylphosphonate)-5-phosphate).",384,1.0,-0.07156901,-0.08368602,-0.08406387,-0.022422045,0.046510626,0.048138767,-0.0066614873,0.0043354495,0.015699703,0.053625252,0.0184895,0.072262876,-0.043210987,0.09277969,-0.018376948,0.012858045,-0.10054112,0.019412503,-0.0117939925,-0.01593109,0.085836336,0.070126,-0.017955845,-0.040509626,0.05033801,0.016739475,0.094229095,-0.06846283,-0.023300955,-0.03675045,0.019413175,-0.031165889,0.115333684,-0.098758005,0.021209802,0.107983984,0.0014957514,-0.06144353,0.06969349,-0.003489435,0.018808028,0.053343542,0.047519576,-0.022940557,-0.05653535,-0.032147452,-0.084684685,0.039958704,0.058131993,-0.035110142,-0.06980916,-0.047588527,-0.023185054,-0.011426274,-0.02568817,0.07161062,-0.00019417382,-0.0146005945,-0.0023280906,0.031943504,0.05718625,0.0020044933,-0.023093672,0.013339603,-0.0044089886,0.015976442,0.078946844,-0.07114669,0.0071849013,-0.061080944,-0.03268248,-0.022654647,-0.00567288,0.014343751,-0.0037898077,0.0009860896,-0.001937223,-0.048428275,0.007499806,0.025960492,0.0542882,-0.025065415,-0.019490005,0.017865518,0.008910198,0.042295575,-0.06622003,0.008120368,0.058671072,-0.0063221455,-0.025449648,-0.039634865,-0.020626303,-0.08980065,-0.033226237,0.027571788,-0.049563926,0.01192867,-0.0074080755,-0.04417959,-0.02549885,0.11247425,-0.0058774524,-0.09660606,-0.011462143,0.015616516,-0.073369496,0.06260523,-0.014916375,0.03125875,0.0010949181,0.038851105,0.04933806,-0.029568167,-0.017363532,0.03318878,0.00083917385,-0.050151862,-0.08330614,0.011291571,0.020392595,-0.021001056,0.0021594716,0.039932918,-0.02377895,0.016979074,-0.112930976,1.1372152e-33,0.10558275,0.044754382,0.106311195,-0.071045,0.03831631,-0.025141144,-0.10203642,-0.04442539,-0.006969871,-0.042093806,-0.05857694,-0.07809047,0.05728498,-0.061839387,-0.004574687,0.006306318,-0.015530193,0.086119086,0.035335157,0.03459918,0.0026961293,0.0720909,-0.060425196,0.051224872,0.042867098,0.041768238,0.01272385,-0.053723127,0.044776488,0.008911905,-0.0025300686,-0.044805735,-0.17039664,-0.01854362,0.010670348,-0.057470288,-0.10120056,-0.10419987,0.03600458,-0.0007386741,0.011199383,0.002261714,0.044246573,0.0913208,0.007875984,-0.019411301,-0.02352456,0.055963747,0.047244396,0.13409898,0.030146414,-0.035076395,0.050292533,0.049168337,-0.09373686,-0.0111631965,0.0045072245,-0.02113925,0.053475674,0.08011366,0.031600337,-0.034894116,-0.03888822,0.02153564,0.0061760717,-0.030933885,-0.012643099,-0.09900479,0.014658408,0.082847066,-0.016192172,-0.0732489,0.07413438,0.04960683,-0.023391902,-0.06334184,0.033482507,0.041971635,0.012936863,0.03681307,-0.030341456,-0.022497915,0.0018679353,-0.025915612,0.011849093,-0.052156147,0.0011761416,-0.066169895,0.01859222,-0.038061894,-0.0013297051,-0.05047178,-0.087742,0.06535556,-0.044587683,-3.012692e-33,0.08892536,-0.09018788,0.06084284,-0.05897,-0.11891434,0.01593542,0.034393452,0.048152678,0.018064352,-0.042549204,0.04754994,0.0034862303,0.050721597,-0.03862919,0.012060455,0.037243597,0.04951929,0.07760275,0.03621768,0.033800308,0.05165905,0.05816245,0.06773978,0.038855165,0.10214741,-0.059408374,-0.0015251944,0.025859263,0.0010243244,0.08420445,0.06183744,-0.0029256542,-0.05046813,-0.04937173,-0.0723472,0.03854666,0.014793896,0.0053730696,0.0048357826,0.017250277,0.020732403,0.058479164,0.030974293,0.04873635,-0.014125603,0.0490107,-0.0075781993,0.024409143,-0.05112319,-0.07906159,0.010295112,-0.014420834,0.02098424,-0.011113174,-0.017933311,0.023306364,0.010724956,0.04471423,-0.090556845,-0.035835136,-0.015853249,-0.0538773,0.02838924,-0.0013617863,0.020327203,0.03621049,0.10706456,-0.0018573252,0.012249729,-0.04891003,-0.03613805,0.02722737,0.07274023,0.10738457,-0.017000051,-0.028577441,-0.114118986,-0.04958656,0.018658025,0.00902687,0.013036023,0.016273756,-0.053721316,-0.042216215,0.038170513,-0.07821254,0.07710444,0.11141262,0.0077303746,0.006746866,-0.066585116,0.049382064,-0.012355228,0.06535262,0.09689107,-4.0628677e-08,0.08585346,-0.0043568183,0.010859749,-0.098046854,-0.03572244,-0.03266474,-0.002373681,-0.019434491,-0.012940242,-0.047057282,-0.05119759,0.04350621,-0.042959366,0.0021904975,0.031028615,0.039214496,-0.07744084,0.03493129,-0.039720215,0.0044314023,0.017322714,-0.00999698,-0.059902053,0.054940388,-0.032058544,0.041485,0.11571895,0.029160751,-0.022627225,-0.010102626,0.023483442,0.019557929,-0.07090767,-0.013833785,-0.12457922,0.004581337,0.0024522066,-0.033059567,-0.030480642,0.09017025,-0.060191594,-0.050294686,-0.07568887,0.05131043,-0.028953075,0.04615409,-0.037394915,0.04680946,-0.0024433765,-0.029267646,0.04298746,-0.0001603689,-0.06886982,-0.09859163,-0.113897964,0.020008843,-0.019733764,-0.052090235,0.039930787,-0.017655697,0.0140455505,0.010236864,0.13903098,-0.02319361 +5.3.2.7,"This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.1.111 (1,5-anhydro-D-fructose dehydratase) and EC 4.2.2.13 [exo-(1->4)-alpha-D-glucan lyase]. Ascopyrone P is an anti-oxidant [2].",384,1.0,-0.03745515,-0.0318518,-0.10862791,0.038700983,0.086087435,0.014699699,-0.06333437,0.008661921,-0.01553489,-0.013189807,0.0023414674,0.07245969,-0.076913446,-0.026309209,-0.12693933,0.06440749,0.006137664,-0.039357603,-0.02125992,-0.02924596,0.05604762,-0.049715977,0.0032511377,0.020629125,0.08573673,0.021379216,0.031244291,-0.078143775,-0.07790863,-0.08980693,-0.0064385394,-0.08025817,0.08888598,0.0076935547,0.019338055,0.07043783,-0.040359277,-0.053409286,0.030937232,0.006272239,-0.0076394803,-0.056600835,-0.042296547,0.010600303,-0.03175694,-0.03197826,-0.10694016,0.012764408,0.07002528,0.038328372,0.001556092,-0.0415005,-0.05722358,-0.0044213706,0.004410696,0.028125875,-0.05356384,0.012972693,-0.040708814,0.060227945,0.036188964,0.03247347,-0.04417864,0.008400659,-0.010070174,-0.012188202,-0.019192146,-0.04786478,-0.02269997,-0.0086948695,-0.039648004,-0.055763006,0.023533305,-5.719502e-05,0.029989304,-0.026630742,-0.041693076,-0.049308114,0.0073286984,-0.0062814625,0.09178296,-0.0076841456,0.092718735,0.0077106664,0.040406644,-0.05030955,0.019913342,0.031764954,0.05716491,0.028679641,0.047065023,-0.03417037,-0.036152475,0.037761394,-0.0052980306,0.025775475,0.06174127,-0.027020855,0.034191787,-0.0829054,0.012817404,0.07043828,-0.036833473,-0.032027464,-0.03973946,0.048824675,-0.008824372,0.015972681,0.07278173,0.016522747,0.009708604,-0.026523123,0.009630233,0.0030893153,-0.06534355,0.09119958,-0.0012184881,-0.008308962,-0.08383202,-0.0017530889,0.03075878,0.03959885,0.088071436,0.11034372,0.0019352965,0.039537597,-0.06317421,8.346582e-34,0.03306194,0.036807075,0.008999699,-0.00582925,0.043092415,0.009950638,-0.077762015,0.034454394,-0.00022988571,-0.05564724,-0.067907125,-0.089018546,0.06275457,0.031574357,0.0057714204,-0.028585475,0.01847523,-0.06729214,0.04751883,0.027534883,0.03270748,0.014981326,-0.002025435,0.008042806,-0.014424102,0.047097832,-0.055204555,0.11827231,0.049129393,0.008830555,-0.019802054,-0.076477565,-0.09317273,0.037011966,0.0060057566,0.03259693,-0.09002804,-0.016587133,0.01956327,0.050072726,-0.034494277,0.000386772,-0.019770231,-0.08213805,-0.005001782,-0.04267238,-0.018903997,0.13356113,0.04877731,0.0691956,0.013996608,-0.04746019,-0.00016960072,0.045359794,-0.06432432,0.016794553,-0.058440156,-0.022591682,0.009397831,0.09332051,0.08725965,0.07316135,0.0059607658,0.0013065396,-0.040503126,-0.009022703,-0.03882442,0.012286176,-0.05669542,0.043905914,-0.06640518,-0.057780202,0.09491521,0.016693803,-0.02000869,-0.01444531,-0.00060241536,0.062461555,-0.030784454,0.009847288,-0.024511604,0.014765866,0.035061218,0.012187915,-0.06375118,0.018244479,-0.0050941007,-0.04640308,0.023611816,0.03285857,-0.0072647925,-0.021543792,-0.044471454,-0.0020681554,0.023226585,-2.7271673e-33,0.1312742,-0.13047439,0.08325329,-0.06527109,-0.05982605,0.06720765,0.07461539,-0.09565443,0.044807993,-0.0053195725,0.03946135,0.043549024,-0.03055925,-0.12245734,0.08031702,0.004424777,-0.05779384,0.08533578,-0.088906325,-0.02165391,0.043219022,0.09602392,-0.031879846,0.032301422,0.016099976,-0.02146815,0.030093867,-0.0599393,0.027764967,0.07007173,0.02108207,0.035957076,-0.031462606,-0.040923804,-0.011835884,0.07817009,-0.090271994,0.025839819,-0.037615284,0.04077081,0.027094416,0.13556413,0.008875053,-0.0017093633,0.09822528,0.01909725,-0.11950922,0.009836797,0.019047722,-0.08647988,0.02908205,-0.011591972,-0.014386318,0.03291438,0.034797046,0.06132808,0.02486291,-0.0008080165,-0.027263226,-0.032549966,-0.048311055,-0.048890166,0.06514372,-0.037197758,0.062351003,-0.047303278,0.02619148,0.05515567,0.037786473,0.04907972,0.046567034,-0.025534788,-0.05016708,0.10880506,-0.04175344,-0.03987619,-0.04586224,0.01871883,-0.013114535,-0.0050169253,-0.015252632,-0.011374948,-0.0030232759,-0.017268864,-0.0336193,-0.09046605,0.040722452,0.093594424,-0.0009332968,0.010285118,0.015374858,-0.018107807,-0.036891326,0.025679192,0.09937616,-4.209797e-08,0.034682505,-0.06990142,0.016956609,-0.056834996,0.02555281,0.012379842,0.009360656,0.051704563,0.030290958,-0.041910805,-0.051095404,0.10106902,0.026742173,-0.046298232,-0.04809827,0.027760657,-0.016352028,0.07820467,0.022940852,0.035217267,-0.11301239,-0.03333795,-0.16065075,-0.0032265855,-0.0046981927,-0.07476478,0.07869334,0.086895525,0.014089419,-0.042788494,0.015012631,0.017296787,0.0706991,-0.10197721,-0.013758123,0.011271597,0.03161924,-0.019464001,-0.008990399,0.09288363,-0.03211229,-0.003867605,0.026411885,0.0022565464,-0.031391073,-0.0021027713,0.0004561491,-0.020462308,-0.034054656,0.06661631,0.04387654,0.032926396,-0.061275683,-0.049367793,-0.061392043,0.00083981466,-0.05976074,-0.06576429,0.0061571207,-0.0943727,0.041116532,-0.020224579,0.15698238,-0.0077238865 +5.3.2.8,"This enzyme has been characterized from the bacterium Pseudomonas putida KT2440 and is involved in the degradation pathway of syringate and 3,4,5-trihydroxybenzoate. It catalyses the interconversion of two of the tautomers of 4-oxalomesaconate, a reaction that can also occur spontaneously.",384,1.0,0.0028764987,-0.006270888,-0.11639784,-0.047813863,0.013708634,-0.0021740352,-0.027510071,0.0608197,-0.0028143201,-0.03567267,0.029241418,-0.034498185,-0.035930336,0.07710748,-0.08128698,0.10063961,-0.09786226,-0.00036623815,0.0067123435,-0.009443694,0.032467563,0.03866971,0.0007805814,-0.007945053,0.056652684,0.037834704,0.045654234,-0.034314737,-0.031387914,-0.029615482,-0.030447174,-0.06864242,-0.046911035,-0.03976328,0.07766196,0.037105132,-0.034850314,-0.045435447,0.094084054,0.01753956,-0.00071019883,-0.054408006,-0.0520103,-0.035795327,-0.03294812,0.026743492,0.01931783,0.04204028,0.022557477,-0.051435325,-0.07470234,-0.040411156,0.010370563,0.030650392,-0.022576788,0.025601046,0.014885055,0.04879066,-0.06046577,0.04337701,0.029175647,-0.056701753,-0.014633885,0.04964893,-0.03118376,0.019145451,0.070239305,-0.021379575,0.017679248,-0.043209206,-0.08331658,-0.060892273,0.021601705,0.02261926,-0.007869215,0.0063804523,0.047007624,-0.057525396,-0.022930825,-0.029825525,0.010377369,-0.0024261407,0.00890848,0.06784227,-0.020719554,-0.017746283,0.026414465,-0.027122594,0.09687531,0.04385175,-0.006707883,0.048029102,-0.018360421,-0.00022653813,-0.088470064,0.08400425,0.03963646,0.083813936,0.03991591,0.013928076,0.057806622,0.042007525,-0.013791384,-0.12322126,0.003489606,0.022815717,0.0193955,0.030506525,0.031021215,0.022437865,-0.055995375,0.012729346,0.05997943,-0.007367705,-0.033808473,0.08824652,0.029790126,-0.0154722305,-0.07741388,-0.055949286,0.028626164,-0.06400092,-0.024275536,0.0013428293,-0.011654163,-0.029562982,-0.102431394,1.9261996e-33,0.059188038,0.061349306,0.019517783,-0.00016079737,0.015432292,0.023742829,-0.08662433,0.022716887,-0.026293628,-0.026639758,-0.113060415,-0.14430021,-0.0019465549,-0.06613475,-0.03943164,-0.026283644,-0.059155457,0.025548913,0.05773195,0.05008596,0.01323522,0.06663281,-0.08372257,-0.008014555,0.0019244554,0.10287322,0.086473055,-0.018936127,-0.014837465,-0.022159243,0.022817103,-0.0632925,-0.12083104,-0.032565698,0.060646463,-0.056030754,-0.059428617,-0.005751907,0.029142369,0.061037406,0.0637754,0.029850578,0.0033320684,0.026743364,0.13503426,-0.05891571,-0.023655683,0.19903128,0.016288238,0.07749529,-0.029309163,-0.06293058,0.10715671,0.06780806,-0.03817792,0.013562141,-0.053138293,-0.030673767,0.033546537,-0.025810897,-0.01308731,0.02305542,-0.038344145,0.0061869244,-0.011974573,-0.02429137,-0.026390051,-0.04679971,0.035665095,-0.012834004,-0.08047155,0.030524127,-0.0054174718,0.038708784,0.029823517,-0.13067318,-0.041676518,0.032901835,0.07754583,-0.020412186,0.03304608,-0.029902443,0.04925187,-0.035138197,-0.020147435,0.009776567,-0.025827779,-0.021952301,-0.060432702,0.08301297,0.07775249,-0.12409657,-0.060819052,0.042289127,0.027590377,-1.6336229e-33,0.114383005,-0.03995301,0.04958062,-0.02798077,0.0013731766,-0.027170138,-0.06696422,0.08007636,-0.04112552,-0.0071997074,0.08355577,-0.0062622665,0.095839,-0.042640828,0.007416445,0.03477617,0.0054187933,-0.0012170547,-0.042691294,-0.03722232,0.020864842,0.044562023,-0.061309792,-7.7322286e-05,0.040195968,0.048555594,-0.0059795366,0.033191174,0.04927028,0.09993035,0.011305229,-0.0029180872,0.0031066942,0.0019199073,0.021135826,0.02780845,0.0058362777,0.008979927,0.034596846,0.014390743,-0.014808603,0.054283254,-0.03556518,0.02113318,-0.024806116,0.08123886,-0.1233746,-0.010596192,-0.0035606928,-0.08417497,0.009106971,-0.00013921325,-0.04261435,-0.014577225,0.06128694,0.03195861,-0.039145943,-0.017086355,-0.077170394,-0.035039786,-0.028686684,-0.08084947,0.107691154,0.013364049,0.07502198,0.045365583,-0.0284769,0.07864407,-0.007987414,0.028759228,0.04659607,0.00097559905,-0.080216564,0.0025741437,-0.041345574,-0.028156655,-0.041240867,-0.032065988,-0.027665721,-0.015987264,0.0019464027,-0.0366601,0.038840413,-0.06881906,-0.017206063,-0.09949434,0.07857617,0.1300669,-0.06355064,0.04671352,0.023470787,0.06556371,-0.027644409,0.10876801,0.027768606,-3.6124362e-08,0.028800137,-0.054557335,-0.0003850562,0.00054449163,0.007934156,0.04600059,-0.008277468,0.042277258,0.061478443,-0.04467032,0.0029995725,0.052435886,0.0118487775,0.023351291,0.06252654,-0.056787867,-0.10315635,0.010974131,-0.07105828,0.023218926,-0.0061279098,-0.03975205,-0.1202376,0.042314347,0.055349253,0.011557844,0.059441518,0.072330624,0.020404723,-0.05713201,-0.03952227,0.022546235,0.017615426,-0.029745253,-0.102308005,0.06900009,0.0009371844,-0.014135338,-0.015156069,0.007840202,0.019668808,-0.05089865,-0.09667891,0.040813897,0.062180236,-0.028429018,-0.0053953608,0.0047172653,0.0020780142,-0.029133886,0.0315308,0.033242986,0.012218034,-0.061484758,-0.0817837,0.025632972,-0.008384645,0.060274772,-0.032195408,0.017982,-0.026868086,-0.00892145,0.13855611,-0.0027752696 +5.4.3.10,"The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO). This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 5.4.3.11, phenylalanine aminomutase (D-beta-phenylalanine-forming).",384,1.0,-0.032464925,-0.05255628,-0.06759346,-0.066008165,0.107718244,0.028414058,0.0059611043,0.017959742,0.032227755,0.037049122,0.06699044,0.008558806,-0.037543643,0.07185186,-0.08423101,0.0427721,-0.083852954,0.004366821,-0.028223744,-0.106450684,0.07338918,0.011544921,-0.043771747,0.004858969,0.025196847,0.012206108,0.050565656,-0.04504698,-0.00077700306,-0.02240602,-0.025635388,-0.07277243,0.041685697,-0.03667567,0.039680723,0.017528657,0.00093760365,-0.0765384,0.0210221,0.019352695,0.038476102,0.009908321,0.024156163,-0.04843455,-0.02382448,-0.019909637,0.0049020313,-0.008161279,0.06774054,0.010111519,-0.04125846,-0.08799822,-0.020111013,-0.010370824,-0.015460737,-0.0020272236,-0.058549322,-0.02857831,-0.004239892,0.0387815,0.026988504,0.050866947,0.010316992,-0.02923463,-0.02226073,-0.025923248,-0.05128059,-0.09494186,0.0016727226,-0.06687838,-0.027383719,-0.13354622,-0.009779889,-0.046018127,-0.023070177,0.025898438,-0.03839304,0.011332296,0.051796056,0.0027187278,0.00481492,-0.018054351,0.052893516,-0.011554908,0.059075516,0.080480605,-0.005220836,0.001812251,0.09247453,-0.027521357,0.024197677,0.00043951187,-0.06393022,0.017024726,-0.0066780215,0.052191123,-0.0058789747,0.07973149,0.015020454,0.006376226,-0.020722523,0.058637947,-0.02141747,-0.02764321,-0.07476015,-0.006391692,0.03493766,0.10977458,-0.0019934878,-0.04090824,-0.08385742,-0.007478095,0.03463261,0.01210159,0.011503691,0.10538603,0.0054813484,0.02558897,0.027908778,-0.037814673,0.05237784,-0.006150861,0.09209815,0.051582284,-0.021107018,0.07349042,-0.1333657,2.5424655e-33,0.08689518,0.051673677,0.077248774,0.021100469,-0.057642855,-0.03831412,-0.049222685,0.049244367,0.017940499,-0.047892362,-0.08733281,-0.012572047,0.019250238,-0.04975057,-0.07151184,-0.066750504,-0.013021629,-0.027593737,0.046909828,0.03755647,0.04310204,0.06957116,-0.041734207,0.051624633,0.026775803,0.03569479,0.023432959,-0.016713765,0.078390576,0.028993567,-0.11580802,-0.11250004,-0.09639198,-0.03962075,-0.012364023,-0.0020987308,-0.08549254,0.0072786612,-0.008663711,0.08806127,0.012732549,-0.059478372,0.019110307,-0.030305924,0.022770535,0.02950445,-0.055796236,0.061775602,0.00089762337,0.0065213693,0.033288218,0.00350593,0.042172343,0.027602518,-0.111015104,0.03554652,-0.026223505,0.014040658,0.075221464,0.035290714,-0.04795275,0.033545807,-0.04601467,0.0545055,0.02483893,-0.0051326896,-0.035089035,-0.037508313,0.028476935,0.1037558,-0.047257453,-0.026116893,0.07226047,0.05036524,0.044997208,-0.11581132,-0.01198857,-0.048586383,-0.015458666,-0.021668227,-0.018514363,0.07465362,-0.04675377,-0.0003085441,-0.009494116,0.047454793,-0.0110424245,-0.08088046,-0.012756886,0.02558627,0.051154267,-0.060038716,0.022933923,0.05354472,-0.026238982,-2.4925676e-33,0.088085346,-0.13940719,0.022376165,-0.08221062,-0.048385184,0.029586295,0.07429743,-0.04191985,0.06179833,-0.037960835,0.007955374,0.0015549447,0.029060014,-0.0035750694,-0.012038735,0.06912704,0.041832563,0.03450274,0.06994637,-0.0124064265,0.03175821,0.01103641,0.078912556,-0.009824671,0.058980238,0.028954532,0.03645847,0.061577056,0.07893213,0.04276695,-0.050766975,-0.0030306354,0.044692747,-0.03759706,-0.088910826,0.06306147,-0.052726083,-0.05004539,0.022000434,0.009363963,-0.04850194,0.018458057,-0.0024615275,0.077983536,0.011588285,0.0678558,-0.057095405,0.047163147,-0.0005594841,-0.043561257,0.0306536,-0.039579906,-0.06548713,-0.047916736,-0.01287166,0.08753351,0.0769073,0.07363722,-0.064975545,0.105599694,-0.0165321,-0.031059451,0.042225122,0.021857833,0.06635517,0.0624782,0.05775386,0.058391035,0.008633085,0.023509135,0.017977584,-0.019540748,-0.0015504246,0.089438304,0.050212797,-0.049390163,-0.0617009,0.06054914,-0.015475443,-0.06313158,-0.035446726,-0.044451017,-0.023936296,-0.02298534,-0.053260013,-0.10382456,0.053050984,0.1422481,0.05989959,0.05113342,-0.014407102,0.037631124,-0.022172784,0.11046236,0.033213273,-4.1113108e-08,0.027258644,-0.108123034,0.081092566,-0.07838574,0.00019844883,0.07890927,0.03266152,-0.05582576,0.03568578,-0.07396237,0.008702865,0.007250605,-0.05869521,0.031124314,-0.055751123,0.035449114,-0.07774795,0.038161635,0.0077253897,-0.020532154,-0.02183177,0.012331525,-0.090506695,-0.035971455,-0.034960523,-0.022320747,0.037186068,0.09435387,-0.07483155,0.003337633,-0.045018554,0.051526897,0.007946444,-0.07145896,-0.09318818,0.036410216,-0.011292469,-0.033427097,-0.05695741,-0.018458935,-0.03304933,0.01141547,-0.021381054,-0.033543166,0.022562701,0.00038393645,-0.039782476,-0.010578976,0.008495056,0.006843678,-0.005261895,-0.015138497,0.013544903,-0.0089476425,-0.073353514,-0.020418553,0.012469833,-0.101060264,0.03876071,-0.1116185,-0.04956639,0.029858593,0.15332772,0.01655551 +5.4.3.11,"The enzyme from the bacterium Pantoea agglomerans produces D-beta-phenylalanine, an intermediate in the biosynthesis of the polyketide non-ribosomal antibiotic andrimid. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 5.4.3.10, phenylalanine aminomutase (L-beta-phenylalanine-forming).",384,1.0,-0.056457926,-0.027339822,-0.05890679,-0.0587125,0.07762657,0.039814264,-0.007497656,0.045076765,0.07136223,0.031048285,-0.025553988,0.01062788,-0.033195816,0.042239506,-0.093116604,0.04119945,-0.081636906,0.033033576,-0.04444089,-0.0629698,0.04289217,0.07148425,-0.020473909,0.03742664,0.057024185,-0.039838158,0.058736823,-0.10167277,-0.061308846,0.015304919,-0.012209347,-0.056523077,0.09416749,-0.022051949,0.05389587,0.0015919604,-0.024358975,-0.004792124,0.073155954,-0.013676767,0.06828217,0.0016270949,0.05659991,-0.049891822,-0.002072911,0.07159436,-0.050523397,0.012472047,0.054114413,0.0133479405,-0.1025949,-0.06855959,-0.021062616,-0.031325106,0.047673758,0.0025198723,-0.03485336,-0.09631559,0.0016202047,0.014197322,0.03492607,-0.0040830453,-0.04187944,0.0058960393,-0.07613806,-0.088758506,0.02251116,-0.076794505,0.0005086851,-0.036429904,-0.045087323,-0.04551283,0.008593355,0.0014161378,0.0069750845,-0.014354351,-0.029665545,0.019687632,0.030610407,-0.01983509,-7.558158e-05,0.012911001,0.04344826,0.04735032,0.03310079,0.06740278,0.018751817,0.08129245,0.066719845,-0.01522793,0.016579341,0.024148142,-0.039358687,-0.022947012,-0.030013895,-0.029950911,0.023795461,-0.012276906,0.0149061335,0.01701698,-0.021648055,0.010769817,-0.004208351,-0.084281355,-0.11822911,-0.01840073,0.009823733,0.08986847,-0.035374466,0.007848608,0.020027334,-0.008386783,0.03609144,-0.01363893,-0.054476205,0.09333751,0.024651088,-0.023269478,-0.011318619,-0.044430967,0.0016986331,-0.08125868,0.10694107,0.12779182,-0.04156349,0.03688207,-0.094400495,2.815751e-33,0.08834952,0.026884042,0.06133322,0.01652398,-0.05540445,-0.0024600236,-0.056968145,0.0120860245,0.02098353,-0.056953665,-0.12593271,-0.073201425,0.0053544817,0.028755212,0.0067368294,0.03463399,-0.0027115399,-0.060163274,0.043957334,-0.0070202905,0.024056671,0.036176432,-0.03767261,0.09931266,0.060822412,0.0031985973,0.039184395,-0.03987003,0.0441648,0.01773849,-0.020116394,-0.07944705,-0.040892098,0.036518008,-0.031560175,0.048524663,-0.11063933,-0.0107467035,0.015223309,0.15147209,0.018766178,-0.035485145,0.029614301,-0.003350839,0.036541097,0.033922754,-0.023169534,0.065111734,-0.032722387,0.06283152,0.006208776,0.006286254,0.058552623,0.036986157,-0.09803487,0.060508575,-0.038822945,-0.02153176,0.06841923,0.050180178,-0.024612742,0.062440597,-0.017780006,-0.005820128,-0.022867769,0.0003319829,-0.028362418,-0.03681503,-0.00047947618,0.023589965,0.0051905876,-0.04439921,0.059454665,0.07289262,0.044417337,-0.0916552,-0.063007176,-0.02905782,0.0046101,-0.008975014,0.082037896,0.037616365,-0.031412847,-0.028988216,-0.034692746,0.014946674,-0.0048458134,-0.041360125,-0.022622507,0.047373615,0.031090397,-0.1212913,-0.029055187,0.0812456,0.018217463,-2.9113715e-33,0.08565919,-0.1404481,0.009487555,-0.02432575,-0.05972957,0.0161822,0.033358525,-0.021408321,0.039538525,-0.057158705,0.007120324,0.005648987,0.044940714,0.021042872,-0.019204808,-0.008944181,0.03368366,0.06961308,-0.0017224603,-0.00047647758,-0.012382141,0.02643099,0.042140473,-0.03399354,0.055035174,0.04743547,-0.019393979,0.10404858,0.028187254,0.086736836,-0.032289635,0.041179933,-0.004929119,-0.038827185,-0.0677459,0.052234616,-0.054427233,-0.03088019,0.014400489,0.06071233,-0.07484299,0.014803088,0.053089306,0.049568072,0.031208154,0.06330036,-0.032647643,0.04571936,0.0071140677,-0.13748586,0.03331906,0.0125119155,0.05494318,-0.05624261,0.031974576,0.07737053,0.046354562,0.033651397,-0.052253034,-0.012288985,-0.039745953,-0.085401505,0.0915206,0.0028991243,0.03952941,0.087620094,0.012191971,0.09243683,0.020134425,0.0035870292,-0.040549554,-0.022612987,-0.005780372,0.07066118,-0.026804663,-0.05984798,-0.116278924,0.021237357,0.014071917,-0.02812817,-0.03255752,-0.06945529,0.016648479,-0.003859724,-0.06913632,-0.08371843,0.08624312,0.09045136,-0.0068085603,0.048525777,-0.044868633,0.06809229,-0.013491368,0.12127221,0.096167855,-4.4586617e-08,0.08298917,-0.09728187,0.018686369,-0.054905888,-0.04212739,0.030705681,0.044614334,-0.0017565141,0.023628166,-0.09255985,-0.09943637,0.07044181,-0.053794097,0.022038918,-0.01794905,0.05723503,-0.040542938,-0.026828617,-0.017174589,-0.025689121,-0.031980176,0.014279802,-0.07542602,-0.03386099,-0.0801923,-0.043268472,0.060356133,0.025603743,-0.015348157,-0.0413473,-0.06960469,0.04073345,-0.045125272,-0.051206153,-0.050143402,0.046472657,-0.03094888,-0.06425732,0.08024952,-0.03832701,0.016662294,0.022029212,-0.049690165,0.015852036,0.015355993,-0.023950396,0.008121583,-0.02374497,-0.056838077,-0.040794935,0.028527843,0.06354126,-0.0046054046,0.013063263,-0.06399794,0.015481832,-0.007603908,-0.09621897,0.015059274,-0.01777825,-0.08522249,-0.010941277,0.14044961,0.027763354 +1.1.1.347,The enzyme from the bacterium Castellaniella defragrans is most active in vitro with perillyl alcohol [2]. The enzyme from the prune mite Carpoglyphus lactis also acts (more slowly) on farnesol but not on nerol [1].,384,0.99999994,-0.035262577,-0.078069784,-0.09202507,-0.041480288,0.047623992,0.036391787,-0.11655055,0.059113793,0.04614886,-0.06327722,0.0756317,0.009651408,-0.115196906,0.10121318,-0.02403067,0.03742579,-0.06682542,0.07428996,0.0046678316,-0.012109805,0.04955965,-0.019016106,0.003725179,0.0038463343,0.027155923,0.02425347,0.042942658,0.012788911,0.022132833,-0.11542542,0.04073459,0.052596442,0.024444489,-0.031363327,0.016334133,0.043467145,-0.015251638,-0.061389294,0.060504675,0.03146816,0.031021131,-0.031104082,-0.024851544,0.042863384,-0.05922402,-0.027913647,0.010194039,0.087229155,-0.023008129,-0.009596686,-0.06868766,-0.040781442,0.015273873,-0.009777582,0.0007325392,-0.010629809,-0.0015552099,0.014804373,0.009488232,0.060472615,0.040833697,0.08057565,0.0061248457,0.0339765,-0.12643886,-0.012512954,0.042020783,-0.04158883,0.013297052,-0.04966201,-0.011100301,-0.08651401,0.04016439,0.082146704,-0.01083683,-0.07898406,0.021485196,-0.01587451,-0.019262124,-0.039147243,-0.07369844,-0.07216221,-0.015916912,0.082546555,0.01928936,0.010544103,-0.050168145,-0.005797601,0.05006834,0.019101992,0.033083443,0.017595464,-0.0759395,-0.0921604,-0.0079560205,0.078988634,0.014424985,-0.062456485,-0.047123004,-0.0187315,-0.03389486,0.022607857,-0.042564392,-0.1231797,-0.05301582,-0.019817743,-0.024216672,-0.022068372,-0.021077702,-0.04174117,-0.008068593,0.051088728,0.0753105,-0.0014972845,-0.070159554,-0.0012579812,0.056469046,-0.0917803,-0.082728334,-0.023793835,-0.07446542,-0.027210306,0.03363622,0.058963683,0.014501189,-0.025319703,-0.013108931,2.3265454e-33,-0.01834568,-0.011563868,-0.0597307,-0.027801877,0.015957164,-0.084341854,0.00030970582,-0.009640526,-0.025279483,-0.074011266,-0.039305422,-0.02122494,-0.021448,-0.0032607897,0.049113527,0.0067480425,0.06626172,0.0062260404,-0.010263391,-0.026681315,0.043132722,0.03582233,-8.508968e-05,-0.0086949235,0.04748457,0.10426319,0.0828296,-0.042313755,0.09588365,0.012665525,0.04869281,-0.05469505,-0.054467376,-0.002989434,0.033127673,0.07881253,-0.10024942,-0.016701031,-0.033304393,0.06943264,0.031323146,0.0757725,-0.002052627,-0.00081364583,0.015576241,-0.023430273,-0.0729366,0.16402401,0.03150372,0.015751636,0.09991767,-0.006199278,0.079889454,-0.042520933,-0.09867067,0.06315426,-0.034767207,0.0025037576,0.01844614,0.020790458,-0.01726024,0.01650735,-0.019231042,0.010891884,0.016055869,-0.005618553,-0.038624786,-0.034981348,-0.0059469217,0.019164497,-0.07219683,0.0008931538,0.0026210085,0.0064598625,0.003350888,-0.022705274,0.024522666,0.017911455,0.014967274,-0.020814545,-0.049073968,-0.03840646,0.008011506,0.0011516709,-0.015438224,-0.029273836,-0.07747863,0.017242258,-0.028386356,0.07712103,0.08812021,-0.114733666,-0.051072184,0.046631325,0.036093403,-3.506292e-33,0.03513407,-0.09148107,0.02858813,-0.01964828,-0.0053712395,0.10318455,-0.010905313,0.062442727,-0.017950267,-0.017743928,-0.010119152,0.027408728,-0.06371024,-0.02714957,-0.046609562,0.06584891,0.0947117,0.03867438,-0.0538154,-0.039720196,-0.040081516,0.092676856,0.06256747,0.0025783498,0.040241957,0.015828388,-0.018261412,0.094108075,-0.059071705,-0.00884119,0.067321144,0.012487347,-0.05446762,-0.09033417,-0.041262824,0.03628463,-0.06787176,0.03505936,0.022600507,-0.03248912,0.032133456,0.009094588,-0.08152893,0.06907469,0.026782598,0.050832096,-0.077169135,-0.107244946,-0.011324618,0.0030460588,0.022251686,0.043315634,0.043283477,0.00712489,0.069681175,-0.019240502,-0.011541696,-0.091333985,-0.016246825,-0.042839397,-0.0985009,-0.040879916,0.05389808,0.003046972,0.049512383,0.01978261,-0.016362112,0.10795291,-0.0148171075,-0.066328764,0.07925298,0.043227147,-0.023160955,0.12956679,-0.10860643,-0.00032632615,0.036458455,-0.07219893,0.011511113,-0.031723578,0.0028632206,0.008896144,-0.04435756,-0.067904636,-0.0058920807,-0.053832218,0.071133316,0.04788453,0.022184828,0.037069183,0.04914362,-0.008456098,0.027286459,-0.0074342354,0.101557665,-3.515274e-08,-0.013782496,0.0104693305,0.04881477,0.03444189,-0.000415805,0.01167215,0.016989343,0.13562056,-0.010378428,-0.07987664,-0.0340982,0.07139942,0.084069684,0.028355557,0.082668886,0.044908553,0.0072107688,-0.03357476,-0.031807844,-0.050254725,-0.020114206,0.009725966,-0.06685915,0.056107108,-0.008083455,-0.032380138,0.018802216,-0.0071431315,0.006842268,-0.06022351,-0.048013337,0.06089763,-0.033515316,0.028221143,-0.078143865,0.022334805,-0.007978799,-0.017207883,-0.029714802,0.059104543,-0.019820757,-0.012758536,-0.02421488,-0.0013026254,-0.021512087,-0.0043533556,-0.0024395566,-0.033967193,0.06559984,-0.0036933224,0.10047394,0.015258826,0.029126147,-0.04819121,-0.14708348,0.036300544,-0.026038608,-0.037451953,-0.030184207,-0.08854935,0.012648306,-0.013562557,0.1526055,0.06724729 +1.1.1.348,"This plant enzyme participates in the biosynthesis of the pterocarpan phytoalexins medicarpin, maackiain, and several forms of glyceollin. The enzyme has a strict stereo specificity for the 3R-isoflavanones.",384,0.99999994,-0.010713494,-0.037747312,-0.19388533,-0.007928972,-0.012896558,0.088148,-0.046674315,-0.0040336344,0.01022486,-0.0360136,0.047192894,-0.048679136,-0.12364437,-0.08154811,-0.06782401,-0.01317386,-0.086595766,0.02109424,-0.0153351305,-0.049983967,0.04600471,0.035867322,0.0021901613,0.043393034,-0.016805492,-0.036366656,-0.020836757,0.00791549,0.004190556,-0.040772233,-0.052876662,-0.03037545,0.049286995,-0.009153459,-0.024894496,0.07452545,-0.066821456,-0.0065518175,0.07257643,-0.026726129,0.07070046,-0.03668642,-0.0021870544,-0.03815144,0.004031966,-0.014497799,0.044568695,-0.017813444,0.06503487,-0.034633063,-0.049633905,-0.05284938,-0.021116003,0.031672645,0.04759847,0.001704468,0.04162366,0.07573643,0.03975403,0.04649749,-0.020513268,0.011921704,0.04808795,-0.0061055594,-0.015353302,-0.06789098,-0.05893777,-0.037567075,-0.0097368965,-0.05451711,-0.03696275,-0.035661064,-0.0040920894,-0.014556352,-0.015319598,0.14530542,-0.07585255,0.036017403,0.000114754854,-0.0019845946,0.054967202,-0.0070992038,0.04638697,0.13548982,-0.02270912,-0.014395379,-0.0149707,-0.004646913,0.031852197,0.002728719,0.09198927,0.034451388,-0.041479588,0.020422341,-0.03951644,0.03127653,0.05632953,-0.037299316,-0.010832883,-0.0090489555,-0.023636991,-0.023303602,-0.024275752,-0.062374238,-0.033149187,0.049704906,-0.041861493,-0.004879943,0.09654568,-0.0015557518,-0.063166566,0.022929568,-0.0074045113,-0.020181503,-0.037974935,0.035710018,0.014861244,-0.05876578,0.03761009,0.0021713898,0.018768359,0.01714274,0.03676003,0.051051773,-0.022490226,-0.006578021,-0.044708967,2.8353027e-33,0.046036094,0.050181303,-0.0053642555,-0.014473359,0.08534221,-0.06260509,-0.036522277,-0.1003869,0.02325729,-0.083530314,-0.10447619,-0.07539617,-0.05104586,0.044412773,-0.044838946,-0.03150176,-0.06329792,-0.014883606,0.068288215,0.007190981,0.019882347,0.017490791,-0.15438852,-0.008237858,0.002977653,0.122580454,-0.047120966,-0.008103033,-0.015202434,0.00064992125,0.00286862,-0.051525924,-0.074137755,-0.02048413,0.039102834,-0.03683268,-0.035174023,-0.07982768,-0.061347615,0.05281351,-0.03449978,-0.035993308,0.011086188,0.00740024,0.07481673,0.049889408,-0.029472515,0.08129323,0.07069265,0.069936514,0.017906437,-0.02104085,0.08733813,0.051913183,-0.008346049,0.047123075,-0.00409725,0.028834322,0.08384065,0.074922785,0.026919205,0.044786002,0.011382992,-0.021872075,0.005143709,0.072256595,-0.06624438,-0.010652241,0.059439655,0.06191042,-0.015210504,-0.023928164,0.014229337,0.04767133,0.040446628,-0.017009819,-0.011987372,0.018853119,-0.0451303,-0.07647288,-0.032452263,-0.019814556,0.032775715,0.009562913,-0.09205624,0.029589847,-0.057051312,-0.018429773,-0.028394958,-0.0020295894,0.08704954,0.02195746,-0.04008138,-0.0021447658,-0.0547939,-3.5387508e-33,0.07923794,-0.05418942,0.06842605,-0.054932147,-0.07547734,0.03894232,-0.094408475,-0.030742055,-0.020343656,-0.011567581,-0.01237295,-0.05930386,0.039232336,-0.011818544,-0.058983926,0.08111456,0.039518956,0.09015896,-0.025696471,-0.028984819,-0.058815833,0.025779271,-0.05224311,0.09046931,0.029298183,0.0023773534,0.024785386,0.068592384,0.004786331,0.032524392,0.00673797,-0.0017431468,-0.040627558,-0.0045395135,-0.02892947,0.051380955,-0.057831142,0.02851708,0.015619397,0.04107797,0.037728056,0.014085289,0.025752919,0.012224835,0.008466621,0.035410527,-0.03246411,0.043393124,-0.04079,-0.04918254,0.031906243,0.061242882,0.05495139,0.040521022,0.04567344,0.054335665,0.053046368,-0.044732105,0.032493066,-0.016135428,0.014150384,-0.07560404,-0.021674026,0.03618257,0.04182345,0.06759051,0.016516412,0.011818703,0.04463209,0.06881503,0.105129,-0.051734593,0.06356717,0.080178685,-0.045852706,0.045697216,0.01841081,0.00093686907,-0.018854681,-0.004593561,0.023573164,0.022175495,0.06605068,-0.10590828,-0.068243586,-0.01264009,0.011863672,0.082233936,-0.0030267658,0.03568682,-0.0127563635,0.02677578,-0.08118685,0.008210508,0.078436024,-3.4214878e-08,0.08856283,-0.07540121,0.039607394,-0.066687755,-0.026955647,0.010673725,-0.012828304,0.04042689,-0.035393905,-0.023439843,-0.05524414,0.004734103,-0.001937839,0.0009857574,0.009825451,0.09474125,0.023529839,0.086062916,-0.013810833,0.043306503,-0.15981181,0.018079234,-0.12487087,-0.024138916,-0.03503398,-0.03519977,0.0073321084,0.09985178,0.04787004,0.050438806,0.025512978,0.080869325,-0.03779287,-0.062797256,-0.13737214,0.042184405,-0.054940242,-0.08756779,-0.04238996,-0.0038066201,-0.033479735,-0.000408862,0.032062344,-0.04475137,-0.022929106,0.021872949,0.042493697,0.022120064,0.021937564,-0.028862385,0.05372984,0.0062912046,0.029060185,-0.021401245,-0.10232096,-0.01744153,-0.019009849,0.026633212,-0.040173348,-0.02915899,-0.09297797,0.029714089,0.21329445,-0.017655037 +1.1.1.412,"The enzyme, found in certain bacterial species, is part of a pathway for the production of olefins.",384,1.0,-0.044429827,-0.05636413,-0.06620593,0.046663143,0.105557896,0.03741746,-0.07118345,0.04718493,0.051458925,-0.00039817212,0.0354706,-0.045091767,-0.06937565,-0.0036383462,-0.04981107,0.006859425,-0.11420738,-0.03687753,0.001141157,-0.011179871,0.096115984,0.070840456,-0.0007790317,-0.019229518,-0.01635848,-0.012123667,0.0569074,-0.053994957,0.03148495,-0.039129898,0.021482293,0.01732825,0.041443054,-0.04796046,0.03828724,0.029355288,0.01828349,-0.12114555,0.015952533,0.018797204,0.05895965,-0.016779805,-0.0006334267,-0.055811007,-0.009310877,-0.029698541,0.009412034,0.02091658,0.03763157,-0.037947174,-0.06766457,-0.054510023,-0.04204033,0.012633496,0.052683502,0.06135044,-0.017192822,-0.090783566,-0.059714783,-0.0055838907,0.06295182,-0.0015117445,-0.014404637,-0.019942153,-0.011285425,-0.028797273,0.06442254,-0.049161494,-0.016550912,0.00021774803,-0.08907382,-0.054368664,-0.04970718,0.12803711,0.023377614,0.00080947357,0.051548276,-0.035868593,0.042206626,-0.0039615156,-0.001417151,0.0034575558,-0.030823663,0.083994634,0.019867267,-0.009107582,0.053416736,0.031858377,0.07306246,0.03041684,0.002582433,-0.06467944,-0.024206119,-0.0871949,-0.004464759,0.020225974,0.0053628017,0.01629556,0.08911099,-0.058175456,-0.06988684,-0.0062753595,-0.022679206,-0.11903833,-0.13378055,0.03664209,0.022339161,0.08008157,0.03344527,0.00951818,0.042608406,-0.02540124,0.040550105,0.004151185,-0.07706749,0.03077939,-0.0034943484,-0.13753021,-0.05243091,0.05778586,-0.047709435,-0.0067007914,0.085273944,0.121774085,-0.038362976,-0.013642762,-0.10851339,-6.477328e-33,0.043380816,-0.025163619,-0.013792114,-0.100526,0.077906735,0.02446655,-0.029569037,-0.009926267,-0.032935932,-0.066048905,-0.0859056,-0.037522968,-0.014260868,0.037562434,0.046794932,-0.058642585,0.060026623,0.07103642,0.0045411102,-0.009129582,-0.006602934,0.03412214,0.007962752,-0.039212547,0.01937357,0.039598994,-0.01299911,-0.019970072,0.057797544,-0.0043868744,-0.0062109577,-0.09657538,-0.07413616,0.031499036,0.0984766,0.018137472,0.004410213,-0.06473544,-0.0016910605,0.067865394,0.019913277,0.03288709,0.034396622,0.027001688,0.0273081,0.0028880613,-0.0648206,0.08155969,0.0684338,0.045248404,0.024743887,-0.021361688,0.08179733,-0.055957463,-0.037437774,0.06367435,-0.1196441,-0.009691121,0.016202359,-0.014424593,-0.07785037,0.054968085,-0.0807883,0.058829308,-0.0132496925,0.05218356,-0.019301405,0.005354663,0.0049359007,0.07797631,-0.058221426,-0.06497,0.019537373,0.029555101,0.03241341,-9.295354e-05,-0.10413653,0.052046232,0.02954425,0.020336317,-0.018381627,-0.056271486,-0.025633782,-0.017069135,-0.053396076,0.005803519,-0.059113517,0.01508915,-0.0002258674,0.020952212,0.061765157,-0.054609973,-0.059875224,0.032332543,-0.02229719,1.7624617e-33,0.068868004,-0.097037226,0.031414688,-0.07597757,-0.041323576,0.07059922,-0.03015301,-0.03721196,0.049383055,-0.0049821185,0.05210932,0.017632829,-0.008013332,-0.10578732,-0.037462976,-0.025439903,0.022668947,0.11124767,-0.01932524,-0.02582,-0.03688022,0.002637592,0.029573034,-0.0069977227,0.057485,0.025773365,0.02036437,0.10573399,-0.06614492,0.05550087,-0.0038942597,-0.0016064128,-0.0504665,-0.06303248,-0.01686991,0.057291742,0.019653598,-0.010647503,0.05839177,0.01586294,0.02826171,0.0140807815,0.033240583,0.010345825,0.029067904,0.04736485,-0.08328017,0.06140596,-0.019669335,-0.09234473,0.035401613,-0.0047622616,0.08084633,-0.014844913,-0.03633937,0.0366688,0.004971286,0.032186024,0.00036192723,-0.056697886,0.0034839245,-0.03982111,0.059267357,0.017001033,0.029204039,0.03308368,-0.015556115,-0.00963638,0.019509155,-0.052770738,0.017487366,0.0042458223,-0.004587552,0.070766896,-0.063039914,0.03683674,-0.07974338,-0.09678252,0.010821355,0.0145876985,0.0014619816,-0.03775476,0.016339615,-0.10381407,-0.03277956,-0.04452345,0.032397978,0.07434197,0.04842693,0.039594732,-0.106502086,-0.019737002,-0.07626796,0.045245327,0.05805304,-2.3956577e-08,0.0038184647,-0.021138761,0.026567923,0.0050095776,-0.02060969,0.0016616401,0.015972357,0.039219152,0.06887056,-0.017867226,-0.031286713,0.05954114,-0.018738013,-0.016128115,0.095291816,-0.027218232,-0.039222583,-0.03946589,-0.026512306,-0.02945076,-0.03044431,-0.023208002,-0.008914724,0.073204316,-0.005764967,-0.07072626,0.055267822,0.089079216,0.013286801,-9.362382e-05,0.008553509,0.029561767,-0.036369044,0.044368982,-0.08520607,-0.014885452,-0.04045028,-0.07401354,-0.035609588,0.06635139,0.041313153,0.06088381,-0.06193942,-0.01985539,0.02834514,0.055260237,0.02249658,0.08555686,-0.0064413003,-0.05803382,0.037958235,0.01576308,-0.049103815,0.022656545,-0.09784419,-0.06451075,-0.03842476,-0.070896365,-0.022841785,-0.0219196,-0.0034265944,0.044091806,0.24682297,0.031333644 +1.1.1.349,Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.,384,1.0,0.03037578,0.007835542,-0.11856915,0.09030466,0.05251184,-0.0076872744,-0.057966247,0.033547275,0.008675297,-0.034484755,-0.009436679,-0.05714367,-0.04348293,0.03206188,-0.11357224,-0.008723579,0.012539118,0.033435084,-0.000722112,-0.032466814,0.011725789,0.037222207,-0.024628524,0.015285169,0.019289128,-0.025527311,0.034095697,-0.021843765,-0.056019872,-0.09849375,-0.05054606,-0.04628028,0.017930746,-0.06289293,0.038594067,-0.0003901196,0.009044002,-0.014132262,0.08948659,-0.015366953,-0.05160741,-0.043825753,-0.0027306778,-0.052216433,-0.12477893,-0.020318568,-0.04129992,0.020235531,0.09451289,0.017046534,-0.07975119,0.023498235,-0.04150646,0.030778138,0.09725048,0.03509907,-0.034522768,-0.03725748,-0.05303952,0.017574092,-0.027651785,0.018248389,0.0040373374,0.013126341,-0.06667854,-0.03021938,-0.035841618,-0.026198618,-0.049666215,-0.007579635,0.002555427,-0.081823476,0.04131955,-0.03238122,0.08789953,0.06347664,-0.020493,-0.002558214,0.056077458,0.01133305,0.06657599,0.0059618345,0.08794846,0.06873536,0.045539144,-0.0010469941,-0.0149351545,0.03897451,0.010541617,0.07721754,0.074098825,0.078959666,0.00546544,0.04399963,0.03161486,0.04885046,0.07906295,0.097034656,0.020220403,-0.046345547,-0.028519174,-0.05194352,-0.030613232,-0.014688195,0.060895536,-0.011556402,0.008076374,0.04612261,0.04313553,-0.016531058,0.055825956,-0.017304542,-0.05131115,-0.095709965,0.031557627,-0.033216216,0.036711108,-0.03146361,-0.049617037,-0.0010899197,0.06881587,0.0580002,-0.023952782,0.029120788,0.055632263,-0.017165642,-0.03279517,-1.0185121e-33,-0.0065768952,0.092892155,-0.10815641,0.011825334,0.053521316,-0.078084774,0.036660884,-0.012282606,0.0030101766,0.04889686,-0.09498122,0.0007343522,-0.11748011,0.009253661,0.059717923,-0.037638605,-0.0015112374,-0.06902454,0.055969305,0.0048754993,0.02362682,-0.00191153,-0.02782773,0.01982895,-0.005339134,0.062457148,-0.013546775,-0.03399849,-0.004721919,-0.017363051,0.042900823,-0.012235579,-0.112287946,0.0008758782,0.03741698,0.047090143,0.0046499018,-0.0058584386,-0.13229041,0.018468445,-0.012372985,0.010815203,-0.042722635,-0.10896333,0.013311488,-0.015406682,-0.10384568,0.06446648,0.08424499,0.015879374,0.09616384,-0.01014385,0.07535931,0.013909095,0.027659556,-0.012345106,-0.058954503,-0.033232287,0.021429522,0.04643708,0.037466437,-0.068926126,-0.010180776,0.065973386,0.021842938,0.0026445684,0.06557394,-0.025160309,0.008803616,-0.023331938,0.012580211,-0.02809162,-0.016629515,0.0010757617,-0.04338575,0.0031684933,-0.11408571,-0.00094636483,-0.0030161063,-0.026663143,0.069081545,-0.015036487,0.001133529,0.016295837,-0.068616964,0.028832365,-0.032925904,0.05578087,0.06535424,0.028612915,-0.01588722,-0.032193914,-0.027730558,0.02489265,-0.01634329,-1.2768861e-33,0.082628824,-0.07879165,0.015166853,-0.008218599,-0.14983402,0.069764726,-0.013298105,0.021235393,0.048772674,0.021005535,0.0067246645,-0.029163104,-0.037141956,-0.0393852,-0.07589496,0.011528585,-0.009197595,0.09287332,0.057730112,-0.044714842,-0.08254741,0.08110079,-0.07010099,0.013526298,0.03768853,0.024106318,0.026858123,0.018198889,0.021734443,0.037594438,0.0038215104,0.04455919,0.02675291,0.013714776,-0.035819422,0.10228576,-0.008001984,0.057441846,-0.004360285,0.010673623,-0.025278479,0.019913167,-0.011015272,0.036685638,0.037782907,0.024497278,-0.024157273,-0.0011226612,0.06611772,-0.02885638,0.045640428,-0.0034854354,-0.0019796435,-0.05374614,-0.05239707,-0.0038998276,0.041740492,-0.054686554,0.123017155,-0.05760104,-0.03988775,0.016049597,-0.019296117,-0.036987983,0.077852555,0.08275709,-0.0988418,-0.050628256,0.03912379,0.0074106604,0.030823907,-0.04550272,0.0061227786,0.068459496,-0.02424683,-0.00018332296,0.028050225,0.031432204,0.027654234,0.07173079,0.021552736,0.011229592,0.07211541,0.005590735,-0.072708204,-0.07678945,0.078549765,0.07528262,-0.090524375,-0.016093079,0.053387623,0.012004036,0.024576096,0.0071363933,0.038794894,-2.0861352e-08,0.030978898,0.037529357,-0.04737819,-0.0918228,0.045564234,0.06255368,0.025793659,-0.013340357,0.02847405,-0.07853556,-0.116726495,0.07827423,0.007952767,0.08252673,-0.007070492,0.0017940345,-0.04926418,-0.020750977,0.0496331,-0.020828689,-0.08683423,0.024263393,-0.09170181,-0.06005354,-0.03070391,0.0029722168,0.012851196,-0.0006762788,0.08921664,0.09910764,-0.06432315,0.044136897,0.049435016,-0.10758231,-0.07705145,-0.06268367,-0.041372906,-0.11570395,0.01880933,-0.06380472,-0.044298362,-0.04526908,0.005529741,-0.090963595,-0.048553605,-0.056918994,-0.034779757,-0.014276167,-0.026135966,0.026384974,0.11136658,-0.012182319,0.028565854,-0.07059475,-0.04354363,-0.0068170615,0.09137318,0.0031602017,-0.03214445,-0.0971083,-0.08244793,0.029693617,0.13425022,-0.0015883802 +1.1.1.350,"Involved in catabolism of purines. The enzyme from the bacterium Escherichia coli is specific for NAD+ [2]. cf. EC 1.1.1.154, ureidoglycolate dehydrogenase [NAD(P)+].",384,0.99999994,-0.021551495,-0.03645774,-0.067287825,-0.028195629,-0.054595307,0.11024474,-0.046063825,0.030542798,-0.011831321,0.022411114,0.0029116147,-0.023694566,-0.060794435,0.047178395,-0.057668664,-0.028050924,-0.06527215,0.010309917,0.076981574,-0.028646825,0.06956354,0.013193197,0.014591078,-0.041760325,0.048555173,0.0440365,0.02197485,-0.006585934,-0.03214655,-0.06424479,-0.052360255,-0.028105995,0.033281904,-0.038792767,0.03363109,0.06637112,-0.07454596,0.0074859546,0.06604308,0.04744263,0.01604581,-0.024099486,-0.05225964,0.02398396,-0.01965865,-0.04755275,0.04868625,0.068251364,0.010996404,0.003709429,-0.027430708,-0.017743396,0.055281077,-0.015878445,0.01577341,-0.05488843,0.023822764,-0.04466826,-0.072003245,-0.090216935,-0.00660814,-0.03073408,0.002306659,0.03314746,0.057153534,-0.080499254,0.095330395,0.006060267,-0.031007249,-0.052529685,-0.094020024,-0.009022349,0.01434452,0.0049023298,-0.033139102,0.044851296,-0.06275748,-0.038939774,0.033076152,-0.011387245,0.09087389,0.006328781,-0.019184982,0.07130618,0.04465923,0.047037985,0.017255513,-0.0037649176,-0.031530805,0.0036583934,0.007257057,-0.060332093,0.020164864,0.006730786,-0.07646328,-0.008436032,0.04801621,0.032429952,0.06903296,-0.07991393,-0.010208418,0.12505277,-0.0331107,-0.021981386,-0.0019031324,0.0042990413,-0.024866225,0.09163788,-0.003626197,0.015501161,-0.06427046,-0.020152941,-0.01277329,-0.0072820955,0.009456192,0.090356894,0.08727993,-0.07928867,-0.07423134,-0.07145752,-0.03169226,0.003210584,-0.044595364,0.064702004,-0.045183286,0.009514657,-0.099426284,9.628403e-34,0.101420745,0.009498861,0.0035661748,0.018394073,0.061064176,0.03417508,-0.06904084,0.0116758505,-0.010039232,-0.019652799,-0.07598942,-0.048108276,0.032322608,-0.020436095,-0.005642902,0.021688402,-0.045755617,-0.047800366,0.034873616,-0.011401441,-0.010502297,0.10879886,-0.009460094,-0.00058891,0.002578908,0.061524935,-0.04469746,0.03607392,-0.028340904,-0.03246074,0.05653452,-0.09047397,-0.10223636,0.0036145684,0.07954765,-0.08096247,-0.04227699,0.0003010286,0.0013698295,0.0705385,-0.050244775,0.05346378,0.021812826,-0.059058744,0.05265763,-0.099187344,-0.028907875,0.07482589,0.025019707,0.12387596,0.04115515,-0.009583501,0.13867243,-0.11548134,-0.039175954,0.039192103,-0.024462461,-0.018847333,-0.04782796,0.14539142,0.031023556,0.0644417,0.012669531,0.033290133,-0.04070141,-0.009492501,-0.07453314,-0.052907214,0.06696218,0.12140769,-0.06790909,-0.0014699961,0.03285257,-0.03859243,0.05792263,-0.030541675,-0.05096113,0.0123367105,-0.0048616063,-0.017649075,0.024137786,-0.030991176,-0.018976703,-0.013007729,-0.0328444,0.05262804,0.026519576,-0.04983544,-0.014245935,0.06829652,0.04096548,-0.008369262,-0.03409605,-0.049042936,0.09303133,-3.3527167e-33,0.10827265,-0.048605453,0.042363822,-0.14005594,-0.0866915,0.12614194,0.021880735,-0.050607704,0.022043498,0.034850005,0.03605256,0.08560221,0.03564007,-0.04077579,0.020998562,0.022684604,-0.06828456,0.0591958,-0.035364658,-0.04344891,0.009984319,0.09063094,0.0047232835,-0.020030433,0.06332342,-0.01720589,0.003400923,0.059897013,0.042504713,-0.045224693,0.008319692,-0.054227322,-0.046184197,-0.045480654,-0.05086547,-0.010805041,-0.057184838,0.03877785,-0.00558751,-0.015320861,0.011325182,0.013663217,-0.06487907,0.036767446,0.04276982,0.04668712,-0.12578833,-0.03575199,0.031929236,-0.07346898,0.032333963,-0.004722439,0.02128404,0.010749966,0.08760627,0.0044526523,-0.047151715,0.009304427,0.02472928,0.006065839,0.010853237,-0.010965622,0.012811098,-0.006378009,0.031293042,-0.05539958,-0.034126904,-0.00021430937,0.038994268,-0.04512194,0.062641464,0.03683591,-0.041249767,0.034496106,-0.025404735,-0.044985954,-0.081444144,-0.027530465,0.009919336,0.00679323,-0.022720292,0.025674855,-0.040569622,-0.052605372,0.010368462,-0.016530534,0.05307434,0.08175104,-0.014168804,0.017842047,0.016471056,0.0437979,-0.026955148,0.02511493,-0.015079692,-3.6874663e-08,0.08466909,-0.035168026,-0.009184269,-0.05102643,-0.008853669,0.035921726,-0.0066563017,-0.021197034,0.037901618,0.015124559,0.024929151,0.109723344,0.10553946,0.07068799,0.05609847,0.017854098,-0.02899424,-0.044195298,-0.018988064,0.0065478073,-0.104488574,0.024894558,-0.13973969,0.091738015,0.062702894,-0.035374522,0.044588704,-0.00482343,-0.011458606,-0.041128285,0.040586904,-0.0062501,0.04672038,-0.0890542,-0.02562335,0.045829576,0.018006861,-0.055622716,-0.023354407,-4.4614353e-05,-0.015342564,-0.083645515,-0.047137618,0.0094484165,0.013034279,0.05179183,0.010109747,-0.0125080645,-0.041240636,-0.0010335621,0.025752187,0.02825199,-0.0042102463,-0.059385836,-0.097709954,0.03799357,-0.029017497,-0.1260354,-0.0007555909,-0.0522773,0.10152839,0.020414809,0.1609045,-0.004700898 +1.1.1.351,"The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP+ and can accept both cofactors with similar efficiency. cf. EC 1.1.1.343, phosphogluconate dehydrogenase [NAD+-dependent, decarboxylating].",384,1.0,-0.03819731,0.020858215,-0.029926825,-0.05078262,0.03299637,0.013652884,-0.059462935,0.003492831,0.039435238,0.009518181,-0.0058761435,0.060002055,-0.12993757,0.01416895,-0.031054927,-0.010990105,-0.01802155,-0.003434573,0.027413987,-0.025565952,0.12635958,-0.018940099,-0.034927454,-0.05097636,0.08296964,0.031109042,0.011847307,-0.008953863,-0.01994983,-0.08510249,-0.01740873,-0.029501935,0.025403494,-0.050883126,-0.010104084,0.09566979,-0.021437773,-0.0624774,0.027934503,0.057595078,0.0033485175,0.045818582,-0.016749563,-0.017338933,-0.049094994,-0.08631763,-0.015378843,0.071831204,-0.027661929,-0.0076913065,-0.009506465,0.009275372,0.024215845,-0.012299881,0.039474007,0.019690052,0.046185236,0.016041089,-0.116521396,-0.09106563,-0.010920853,-0.037940882,0.01619274,0.028281087,0.04726285,-0.08392318,0.080798954,-0.054735735,-0.013135625,-0.07255914,-0.10898504,-0.045053612,0.034598667,-0.030492999,-0.008051618,0.04870224,-0.0655046,-0.020171495,0.048289955,0.0317878,0.09637482,0.016438095,-0.0040353155,0.05397569,0.053395513,-0.038372334,-0.0045172963,-0.0061040255,0.002550809,-0.015993007,-0.005705616,-0.03386695,0.036848426,0.07393396,-0.09744565,0.03295402,0.010011875,0.0809494,-0.038225647,-0.10335139,0.022810573,0.113570966,0.0021191793,-0.0264033,0.0127915405,0.016792923,-0.014767037,0.1080868,-0.018456334,0.032161366,0.0055118,-0.010957541,0.05222896,-0.0069070137,0.0009312946,0.098004505,-0.020511175,-0.04743456,0.010116102,-0.040494073,0.054824114,-0.050102856,0.008949151,0.039497375,-0.0244924,0.062419947,-0.12492073,2.0764685e-33,0.06802996,0.013316594,-0.0011194731,-0.065209314,0.034241274,0.031110456,-0.09961701,0.008355624,-0.082957715,-0.026445895,-0.041180387,0.015577571,0.07775808,0.014535062,-0.04978937,-0.023042776,-0.06538947,-0.006590916,0.032385338,0.098815136,0.035063423,0.051543,-0.08920644,0.062043555,0.053829953,0.03985398,-0.061513353,0.061179604,-0.07063466,-0.006018265,0.049893886,-0.08977868,-0.10912344,-0.02949477,0.030973103,-0.06326412,-0.033437535,-0.047916252,-0.016188903,0.028699119,-0.035157572,0.014041334,0.0002294837,-0.042918824,0.048107047,-0.054985955,-0.049635846,0.03674154,0.023017442,0.054595336,0.002460442,0.0019739876,0.080282174,-0.020530684,-0.0020034225,0.0075451564,-0.034221824,-0.004571415,0.05377643,0.08655367,-0.0072754305,0.010860677,-0.08090435,0.027762083,-0.029066276,0.0036252628,-0.03459661,-0.06882784,0.043826718,0.0836026,-0.083935745,0.0010418724,0.04341221,0.026524534,0.012396609,-0.045366984,0.03196953,0.040404264,0.0075793774,0.031461757,0.011332608,0.0063716653,-0.042107504,-0.04855744,-0.020114895,-0.00972545,-0.020211942,-0.0031593766,0.018126834,0.021318141,0.019237729,0.0029892742,-0.019962307,0.011023086,0.035343982,-3.518973e-33,0.11044118,-0.07482428,0.0063552256,-0.08297328,-0.034700416,0.107409455,0.06723562,-0.12873845,0.06441255,-0.030431706,0.017841835,0.005495784,0.031143509,-0.014786142,0.045581013,-0.0121019725,-0.06919426,0.04294839,-0.012104662,0.0046281954,0.030975495,0.16236356,0.04974886,-0.006726744,0.044282835,-0.051354367,-0.06615068,0.023146767,0.015882947,0.0080608465,-0.019797351,0.010281312,-0.055253632,-0.020111568,-0.08643446,0.018129472,-0.12144652,0.0073661203,0.04939556,0.0627112,0.026320245,0.007530955,-0.02828259,0.015750572,0.04865933,0.01783922,-0.14188465,0.013257081,0.037504427,-0.037405293,0.018336605,0.09020039,-0.055048496,0.07091377,0.05305581,0.028300226,-0.0029139975,0.038926944,0.06255452,0.05398407,-0.035157863,-0.023081146,0.076717965,0.0029449884,0.03794736,-0.01670378,-0.0070226085,0.047948375,0.06407842,0.0007318426,0.0054218792,0.06080236,0.019963456,0.06345231,0.03426447,-0.0035147408,-0.16860312,-0.008021768,-0.038367312,-0.020174364,-0.032198664,0.0029318086,-0.023609973,-0.041978654,0.021392457,-0.018292166,-0.010174943,0.06441148,-0.03296083,0.039471474,-0.014830817,-0.05186183,-0.059294656,0.047696546,-0.02176557,-3.8761033e-08,-0.019101841,0.011009543,0.045300845,-0.04726992,0.012602175,0.022347996,0.040141705,-0.031209659,0.055356145,-0.0028752661,0.055666126,0.10354791,0.021468144,0.057134476,0.053776935,0.02776644,-0.043525424,-0.0178406,0.004973476,0.030004613,-0.0062023113,-0.0328951,-0.15568538,0.0737443,0.02986477,0.0012135435,0.06391617,0.028587239,0.016910536,-0.035309464,-0.012194083,0.05132837,0.077172175,-0.019536914,-0.06501069,-0.004329828,-0.03462893,0.004615294,-0.07268154,0.039077196,-0.0085861785,-0.12757716,-0.04750376,-0.013686127,-0.0015206083,0.067198314,0.078152046,-0.029994195,-0.087339714,0.05372029,0.023282234,-0.05813947,-0.0041122083,-0.031235011,-0.050989196,0.00457596,-0.021537118,-0.06664683,0.046257228,-0.026123475,0.048228655,-0.0021569459,0.20014617,-0.082118854 +1.1.1.352,"Isolated from the aflatoxin-producing mold Aspergillus parasiticus [2]. Involved in aflatoxin biosynthesis. 5'-Oxoaverantin will spontaneously form averufin by intramolecular ketalisation. cf. EC 4.2.1.142, 5'-oxoaverantin cyclase.",384,1.0,0.023931203,-0.006909405,-0.09403814,0.056768857,0.05131451,-0.0053186174,-0.10946097,0.022895256,0.018296232,-0.081921026,0.06541884,-0.042476404,-0.024183694,0.04916204,-0.15000455,0.011246376,-0.046941526,0.019511709,-0.02249422,-0.004190343,0.04184193,0.048670527,-0.014966797,-0.009123299,0.02201232,-0.029220073,0.010173599,0.032641415,-0.032247994,-0.08553851,-0.039401785,-0.043674536,0.0070108096,-0.08222557,0.0639959,0.0227496,-0.004290743,0.018459009,0.11608895,-0.032227833,-0.0062149456,-0.06734687,-0.011488077,-0.0020095727,-0.01603135,-0.054636337,-0.07953013,-0.005021237,0.038694616,0.012624511,-0.074473925,-0.013567004,-0.0024577074,0.046959806,0.09318355,-0.015638692,-0.0048215906,-0.033446923,-0.017787915,0.009332957,0.021456866,0.015929915,-0.023757374,0.015265139,-0.07117664,0.030619383,-0.00044390434,-0.0330125,-0.05717281,-0.00874385,0.021456681,-0.05146163,0.05317,-0.02060173,0.08895723,0.03911377,-0.05713401,-0.031105792,0.02362246,0.02391307,0.048121974,0.05912471,0.017701885,0.06949135,0.0112565635,-0.04439514,-0.023487244,0.034470957,0.016004665,0.10791642,-0.018314915,0.06123635,0.025271216,-0.0016498785,0.025302278,0.0074766283,0.0916235,0.046626735,-0.008163134,-0.028090596,-0.015557074,-0.029851964,-0.07185863,-0.0120902695,0.013767945,-0.004838553,-0.015587962,-0.011404229,0.06217842,0.016000498,-0.009461702,-0.020445079,-0.040275134,-0.10148284,0.019097427,0.04178842,0.0034659987,-0.018414026,-0.0049686525,-0.009035917,0.040046487,0.05897623,-0.00041289034,0.053098366,0.051618986,-0.008712327,-0.072714224,2.724292e-33,0.035680354,0.005106461,-0.046332095,0.041089624,0.07991673,-0.047958646,0.010911352,-0.029942825,-0.03715837,0.011072664,-0.116841584,-0.016852673,-0.06795595,-0.0071003446,0.07663041,-0.02146278,-0.011467711,-0.059618838,0.01724804,0.031117113,0.034771707,-0.019164097,-0.0667566,0.0138507625,-0.01648937,0.06195282,-0.0042270357,-0.029116603,0.039083954,0.030649018,0.00526922,-0.07155484,-0.11581781,-0.048907164,0.09507237,0.018841753,0.009849506,0.020938313,-0.05932578,0.032496013,0.03483003,0.021264324,-0.0013690746,-0.09980256,0.06253477,-0.0011321228,-0.08882469,0.11435502,0.050182503,0.008652631,0.07304746,-0.031594634,0.07044129,0.022047855,-0.01994076,-0.011976638,-0.10868246,0.024413241,0.026831219,0.017159907,0.0283847,-0.008147529,0.007260307,0.061384033,-0.048696958,0.023918696,0.008592298,-0.045223642,-0.0022225839,-0.006468958,-0.018059973,-0.011076684,-0.049035512,0.000110896624,0.01681535,-0.015504888,-0.06660291,-0.011160189,0.0301072,0.001767249,0.012996655,-0.02151238,-0.034887824,-0.04080287,-0.032967526,0.04574608,-0.013712968,0.050094962,0.0081118625,0.07256786,0.06938716,-0.06726548,-0.041631203,0.060008235,0.009647394,-3.8411504e-33,0.108069286,-0.11961442,0.0872943,-0.11234139,-0.120353185,0.06543322,-0.07734023,0.06190776,0.02550376,0.0006218179,0.009153544,0.062180884,0.011037916,-0.0042079766,-0.054526687,0.02110593,-0.0078513585,0.114221714,0.08066781,0.0070820064,-0.045085374,-0.0003930585,-0.054725792,-0.0059245424,0.039002597,0.094256245,-0.018330036,0.0910022,0.019799698,-0.023759456,-0.06620815,0.02757155,0.014710318,-0.033232197,-0.05612269,0.096789055,-0.038547054,-0.013951113,0.012456303,0.04710283,-0.049875516,0.0331463,-0.07145329,0.07541474,0.07268056,0.042229097,-0.025587821,-0.02512137,0.10071767,-0.052728735,0.056475993,0.03372362,-0.03728111,-0.009436284,-0.020472426,-0.004932566,0.055730123,0.048644982,0.091422305,-0.03885849,-0.019903412,0.0059086927,-0.013648285,0.017589316,0.066259176,0.10513079,-0.021586502,0.0042726994,0.009133996,-0.023997037,0.04011771,0.01421801,-0.017213076,0.019968882,0.0040766043,-0.038423564,0.010007493,-0.0023193948,0.0153992595,0.04678624,0.008234661,0.0074458956,0.05631549,-0.0017490917,-0.08955369,-0.13245563,0.13506472,0.07780488,-0.07864988,0.009495442,0.050352894,0.084202565,-0.017372413,0.016427033,0.05089078,-3.4467543e-08,0.03348513,-0.012906921,0.010513811,-0.055879056,0.022250984,0.02499462,0.0085856775,-0.010632704,0.038786437,-0.05367229,-0.10058578,0.05561597,0.008444945,0.032537896,0.03481149,-0.03230106,-0.012766086,0.018253809,0.01640827,-0.009556562,-0.06383447,0.030760286,-0.06740698,-0.036536124,-0.075547025,-0.07392359,0.03791162,-0.024869554,0.053310897,0.034682926,-0.051748596,0.07880831,0.01633477,-0.10514679,-0.15152578,-0.005409616,-0.08060539,-0.11198947,-0.017590929,-0.0980053,-0.0652591,-0.096989654,-0.025028825,-0.074917085,-0.009451076,-0.054449495,-0.004110682,-0.03653833,0.030644182,-0.044632006,0.081870556,-0.00465938,0.05551852,-0.057525817,-0.03693884,0.014507504,0.069761135,-0.026906807,-0.03770018,-0.08791315,-0.07202027,-0.020247877,0.17099747,0.0078488095 +1.1.1.353,Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.,384,0.99999994,-0.0026724883,0.060570918,-0.14538378,0.08476154,0.062246025,0.0132503295,-0.11627295,0.061857034,0.0037417787,-0.060310487,-0.012529581,-0.05594758,-0.04017293,0.020783367,-0.0975148,-0.0239535,-0.003957368,0.02315139,-0.0105183385,-0.019773984,0.052321244,0.06598852,-0.032268163,-0.0054688384,0.0048188246,-0.028962906,0.035521813,0.0025420354,-0.0440335,-0.07900381,-0.05482425,-0.030995172,0.006467728,-0.034034025,0.09421334,0.057072107,0.028175455,0.020980017,0.11642732,-0.026125947,-0.013224916,-0.04191642,0.0106723765,-0.05703652,-0.08631478,0.012190062,-0.060562607,0.032369778,0.03903646,0.0076498007,-0.115665525,0.015410186,-0.008810716,0.0677489,0.12977543,0.007724327,0.03156322,-0.07838226,-0.051525507,-0.013091251,-0.009831963,-0.030913165,-0.020937383,0.038334385,-0.079964474,0.003612928,-0.036504727,0.0114410715,-0.023373568,-0.079610415,0.016125064,-0.046825882,0.06562501,-0.022916304,0.09051329,0.026609467,-0.04002272,-0.022220176,0.08249529,0.012089477,0.100251436,0.060219247,0.058506247,0.041201904,0.020319263,-0.0567611,-0.011929886,0.08478074,0.011763156,0.08401379,0.0009578939,0.06720106,0.062207974,0.02015675,-0.014845741,0.014759522,0.09276599,0.028019754,0.0055845995,-0.028774245,-0.025122974,-0.023225928,0.018700022,-0.010119447,0.060518466,-0.022942176,-0.005662104,0.04443388,0.062184405,0.011984627,0.03335861,0.015487352,-0.055817522,-0.08824675,0.058899887,-0.029697075,0.08751251,-0.05215725,-0.026455073,0.022170223,0.036575235,0.019470055,-0.0053415434,-0.0021204068,0.0851699,0.0018587732,-0.065052375,-1.0808248e-33,-0.003197335,0.038121425,-0.0781659,0.0033815173,0.12017553,-0.07401124,0.041041516,-0.05765585,-0.021030217,0.07676603,-0.08734821,-0.032968946,-0.118462354,0.044749033,0.033447575,-0.02594224,-0.010689414,-0.05061406,0.022770861,-0.006894672,0.022076657,0.009128694,-0.04374497,0.018729573,-0.0047653476,0.05118486,-0.023187134,-0.0316994,-0.004489107,-0.0008732435,0.066961184,-0.042471964,-0.094198175,-0.03571232,0.06865589,0.016148997,0.0067199846,-0.024219662,-0.13294603,0.009093314,-0.0024628015,0.02216315,-0.009024299,-0.11614606,0.040900722,0.02500599,-0.087549195,0.04833984,0.08044811,0.0030340154,0.10181253,0.012231459,0.088422105,0.0079126125,0.024852285,-0.042086534,-0.08195886,-0.0019692236,0.052775532,0.071527325,0.039633714,-0.02884526,-0.03389379,0.07630294,0.044694353,-0.03828803,0.0042157094,-0.0074911434,-0.017608719,0.018682683,0.03041912,-0.06572592,-0.031288173,-0.0053195534,-0.019402407,-0.009545758,-0.072741166,-0.0391962,-0.030836776,-0.027997475,0.034559205,-0.00015180431,-0.011549316,-0.016585592,-0.09964409,0.04663356,-0.027736854,0.04170179,0.018519789,0.017479133,-0.0048978673,-0.036521237,-0.04446708,0.053565856,-0.028796718,-1.2999572e-33,0.07515918,-0.06509259,0.024057824,-0.08343066,-0.085353635,0.073169924,-0.02122686,0.033205383,0.031348392,0.0248076,0.0021224853,-0.011341383,-0.011527719,-0.013035855,-0.008787105,0.057546977,-0.002537049,0.08387623,0.05698888,-0.0060225576,-0.05870607,0.054035887,-0.08724294,0.008450941,0.00039303122,0.058972605,-0.010087591,0.09246462,-0.00052585796,0.019205187,-0.02373231,0.056445107,0.03736871,-0.038501028,-0.058726113,0.10204202,-0.06417716,0.018884886,0.0120933475,0.03127956,-0.02607755,0.029003127,-0.04924093,0.0446081,0.05839387,0.025932277,0.0041491706,-0.0045148083,0.06828292,-0.029083274,0.016932491,0.012420565,-0.03017219,-0.03282088,-0.03535657,-0.038018342,0.0072587496,0.000564443,0.08211699,-0.05844579,-0.01907879,-0.014611452,-0.040738117,-0.015657634,0.08647746,0.08197591,-0.05972112,-0.075754374,0.038132668,0.014298066,0.021580756,0.008630003,-0.019072015,0.068294145,-0.006708467,0.009201631,-0.023164477,0.0038750626,-0.006994992,0.07883261,0.03956372,-0.0047692293,0.07538068,0.007023563,-0.07171483,-0.14456163,0.12857972,0.026316449,-0.081644125,0.001387065,0.029346319,0.048412044,-0.046072185,0.011399903,0.045143623,-2.4412596e-08,0.046317413,0.020143265,0.006922763,-0.07883854,0.0019151748,0.015324611,0.019214764,-0.012678966,0.026190432,-0.033485763,-0.09351466,0.043838974,0.0069858073,0.06329215,0.05247145,-0.02043595,-0.040868826,-0.003296365,0.007697841,-0.02380045,-0.08673811,0.011967852,-0.046856195,-0.01978585,-0.046902552,-0.00094183156,0.026812326,-0.036732383,0.09929008,0.053150613,-0.05629103,0.07664708,0.042206954,-0.106624834,-0.11448585,-0.013442752,-0.08979318,-0.09114478,-0.017159116,-0.063912876,-0.03892034,-0.08288545,-0.02156096,-0.06179048,-0.08893509,-0.026460804,-0.044659983,-0.0017300901,-0.016967604,-0.021643763,0.107659884,-0.008673914,0.045960117,-0.041067332,-0.060757007,0.006991901,0.045250695,0.0024330576,-0.005593892,-0.0744218,-0.058913648,0.011193796,0.12754402,-0.014802698 +1.2.99.8,"The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo. The iron-sulfur protein contains FAD and molybdopterin guanine dinucleotide. ",384,0.99999994,-0.043630015,-0.07661407,-0.086837925,-0.042665154,0.041136015,-0.06111487,-0.05985536,0.037578702,0.019233538,-0.013484261,-0.002103083,0.03483332,-0.09956658,0.017665477,-0.11565896,0.05575107,-0.051358487,0.044891335,0.030281203,0.015288147,0.008862259,-0.0069311187,0.008079596,-0.06895488,0.023168566,0.03779619,0.018018875,-0.06304873,-0.028622534,-0.019168729,0.0094262725,-0.047474694,0.02405026,-0.0015952621,0.007202819,0.08721886,-0.016101757,-0.010815829,-0.031246578,-0.01631698,0.022214878,0.03259759,-0.033478744,-0.03540332,-0.058936715,-0.015714513,-0.01827583,0.037630744,-0.0035639137,0.047040887,-0.011174341,-0.045491938,-0.051641766,0.015849965,0.0009204445,0.050400734,0.013641801,-0.009806089,0.029993663,-0.02259588,0.017390916,0.027516415,0.03366853,-0.018343022,0.009864843,-0.05285175,0.06531341,-0.06751444,-0.0041296296,-0.073314145,-0.06271762,0.009260114,-0.027475586,-0.024226166,-0.059138127,0.12069055,-0.021786358,-0.038960077,0.12657927,-0.09493553,0.050538234,0.010792819,0.04544303,0.108883895,0.042965546,0.00939946,-0.016225921,0.019994838,-0.0023999412,0.030973356,0.025573336,-0.02237777,-0.042242546,-0.08905586,-0.09063283,0.036815055,0.036660843,0.09815043,-0.09724304,0.016186984,-0.031210275,0.062300727,-0.07983506,-0.10761328,-0.12122204,-0.013455767,-0.02567356,0.07082681,-0.0063182805,-0.003066334,0.02394272,0.02456293,0.08522167,0.040535923,-0.051793806,0.065792635,0.062210504,-0.07602475,-0.080435194,-0.020055022,-0.032521363,-0.022211665,0.05004115,0.0391537,-0.035491608,0.010784912,-0.0144263,5.8211266e-33,0.12848812,0.05467945,0.029847821,-0.035673395,-0.012564474,-0.0119897965,-0.0974456,0.06973286,-0.024651313,-0.011186732,-0.038069405,-0.07648756,0.039365802,0.03758318,-0.009553733,0.062018916,0.01381572,-0.005963049,0.08261279,-0.049096286,0.07063902,0.035431758,-0.00734023,-0.052044995,0.06246766,0.039533496,-0.068430215,0.045387127,0.025481896,0.009671721,0.059166275,-0.1637363,-0.08793087,0.060266178,0.043023277,0.005464558,0.0024547598,-0.035321172,-0.052879095,-0.04228851,-0.0012195344,-0.013983016,-0.005720864,-0.055972874,0.03482412,0.0027106241,0.007601054,-0.0043634973,0.031116758,0.06632721,0.016981315,-0.041401476,0.052049607,-0.03231644,-0.07970614,-0.0032078887,-0.021296348,-0.047764916,0.059216883,0.078890234,-0.0033919597,0.081771426,0.017916402,0.013852582,0.0045260424,-0.015305344,-0.11343581,-0.010812908,-0.0071794,0.06420264,-0.014864626,-0.03746857,0.040036142,0.007762843,-0.06416742,-0.04274063,0.011942041,-0.01755349,-0.027167192,-0.031747993,-0.020832831,-0.06220649,-0.0037964,0.016628964,-0.042608287,0.08162984,-0.033235054,-0.047865868,-0.027495462,0.037869416,0.009512048,-0.053237546,-0.092965655,0.018832289,0.051351395,-6.2116766e-33,0.07995251,-0.08625164,0.040647652,-0.10735746,-0.046059225,0.084813036,-0.0035025456,0.05329838,0.068198636,-0.066096224,0.034635916,0.054817732,0.04097475,-0.073938295,0.031393856,0.00788034,0.017113872,0.044258133,0.00028839233,-0.012490636,0.03402571,0.103856504,-0.010749643,0.028916698,0.05922275,0.03069724,0.037149534,0.01577615,0.0063271774,0.051226318,-0.01275407,0.09988804,-0.00822994,-0.05408256,-0.040883422,0.0135001475,-0.07109822,0.014129794,-0.009333467,0.027333766,-0.058944304,0.026299017,-0.0016040829,0.07362283,0.052120335,0.028233767,-0.1266707,-0.026889425,0.08011574,-0.01177297,0.067982845,0.0088604065,0.017228412,0.046284765,0.10434663,0.08372145,0.03708371,0.023595542,-0.07050318,0.0060100104,-0.048080467,-0.062806405,0.017455485,-0.05412765,0.07277436,0.07457413,-0.0592358,0.09102308,-0.009678292,-0.05161428,0.020411491,-0.024487972,-0.007389093,0.07657404,-0.018623644,-0.05146641,-0.01818436,0.052426368,0.046620697,0.031840384,-0.0552016,0.054385796,0.0013496691,-0.021112647,0.032672487,-0.102320746,-0.007822527,0.12693061,-0.011966851,0.001572481,-0.054475572,0.005811898,-0.033560872,-0.01134331,0.04961322,-4.597773e-08,0.002287591,-0.051484592,0.034993876,-0.032727927,-0.057372008,0.0170766,0.06634762,0.028626204,-0.040184774,-0.050701015,0.0366445,0.10411863,0.012257129,-0.01013397,0.041218963,0.08237752,-0.06645309,-0.022499617,-0.07917034,0.0063806283,-0.046098813,-0.011452381,-0.08368355,0.06862064,0.010839438,-0.05122104,0.06488839,-0.061092053,-0.03514195,0.029540805,-0.022383118,-0.019440718,-0.012398411,0.0013516746,-0.00019141646,0.025728783,-0.02129856,-0.04888052,-0.05342427,0.0126018,-0.028786398,-0.008250511,-0.020680422,0.034720127,-0.01768359,0.027237786,-0.018349532,0.07332253,-0.022628278,0.084890075,0.049576223,-0.007790433,0.01117302,-0.11051563,-0.12958907,0.022920545,0.024327658,-0.061387718,-0.025821716,-0.025004968,0.09574126,-0.037684903,0.1559036,-0.025977852 +1.3.1.100,"Contains FMN. The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The enzyme catalyses the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde. This hydrolyses spontaneously to form 6,8-dimethyl-6,7-didehydroergoline, which is converted to festuclavine by EC 1.5.1.44, festuclavine dehydrogenase.",384,1.0,-0.031061942,-0.0019516916,-0.17766258,0.037780374,0.030074015,0.029116286,-0.09694969,0.044687252,0.023720458,0.0018853438,0.0017020602,-0.12453068,-0.11987539,0.012859746,-0.06809878,0.021336498,-0.09627104,0.023213422,-0.04837502,-0.07074652,-0.0006218569,0.0059804684,0.05294732,0.0010238995,0.03496775,-0.047579147,-0.056322545,0.054497764,-0.01062932,-0.076318085,0.047066424,-0.010117781,0.048865944,-0.012144114,0.019153517,0.07595804,-0.05481144,-0.047746934,0.078732304,0.029378887,-0.027413944,-0.017659677,-0.05173123,-0.0130819315,-0.040590636,0.031069275,-0.015232321,0.12122216,0.0029113505,0.09180283,0.01437938,0.008106985,-0.02236449,0.03578532,0.045049094,-0.013690607,0.023953937,-0.000500094,-0.015406928,0.09098759,0.058643617,0.05989627,-0.09983881,0.02634529,-0.08248955,-0.069284715,0.057721682,-0.09161254,0.06466615,-0.0751407,0.0062059443,-0.067429416,0.011903032,-0.0015732623,-0.015737012,0.09493525,-0.035820223,0.0069483635,0.0040263445,-0.03958368,0.08982039,0.031694923,0.06332593,0.04982207,0.016038038,-0.047178853,0.008547926,0.032585464,0.04616957,0.08457967,0.04738164,0.0050280625,-0.007172681,-0.03622835,-0.051745616,0.09447107,0.08308769,0.059004076,0.02611542,-0.0065711774,-0.00798546,-0.046508547,-0.019602757,-0.045073338,-0.045625035,-0.01869176,-0.00346434,0.079190254,-0.000527878,-0.030763982,-0.0035308353,0.035007168,0.039935477,-0.010859733,-0.0841149,0.1005849,0.0937326,-0.03597972,-0.07487958,0.053844295,-0.0012264283,0.0064238864,0.07458052,0.08166979,-0.0223037,-0.06129646,-0.03707153,4.3561657e-33,0.04172797,0.028979799,-0.0704358,-0.032325406,0.029591035,-0.018535405,-0.036499783,0.053038735,-0.029095717,-0.006434585,-0.0068687187,0.0134075675,0.050135158,0.008615486,-0.02175954,-0.006301356,0.006898533,-0.052582733,0.013235026,-0.032926843,0.003364354,-0.0022391882,-0.046251565,0.002156849,-0.014300614,0.10605966,-0.0004022698,0.067071915,0.010939002,-0.011755814,-0.0054156315,-0.17520086,-0.0067695417,0.02195344,0.04976,0.018915208,-0.09621828,-0.035371795,-0.02589571,0.023270408,0.0259553,-0.011234482,-0.07173031,-0.020279078,0.0102982065,0.0061253384,-0.024370689,0.07628537,0.03300682,0.020583155,0.085804135,0.01384786,0.08943994,0.009246574,-0.054705404,0.04572749,0.029068183,-0.03196742,0.063965,0.06551905,-0.026529297,0.025115138,-0.012328984,0.004456578,0.017634463,-0.11176749,-0.02761519,-0.051130902,-0.020094523,-0.010577017,-0.039833624,-0.07582048,0.026759343,0.007745935,-0.02186005,0.048011187,-0.05796086,-0.010947244,-0.018199021,-0.07631953,-0.0060900473,0.020057684,0.063425146,-0.05211352,-0.06722377,-0.028909473,-0.110397115,-0.049471945,-0.048273984,0.0062469123,-0.01202121,-0.04952522,-0.011103237,-0.005147813,0.10763567,-5.263246e-33,0.045499023,-0.021117264,-0.0044370214,-0.051371776,-0.013018806,0.08167516,-0.012691808,-0.025860485,-0.00626729,0.03391514,0.045639396,-0.020986414,0.016731028,-0.03358752,-0.019735247,-0.0001230625,0.06400823,0.12214716,-0.0024797984,-0.0054848315,-0.00075344526,0.10723797,-0.041843377,0.006367192,-0.0143767325,0.023236273,0.041127138,-0.03884221,0.04002719,0.11282623,-0.035642616,-0.028807078,-0.018732691,-0.031894594,0.04510712,0.03845322,-0.02454808,-0.0018438274,0.0016905571,0.04952721,-0.003520561,0.058751315,0.023205696,0.028871503,0.06811641,0.053035382,-0.04662231,0.017019298,0.03394352,0.0018534976,0.0631305,-0.012981025,-0.05925293,0.04134704,-0.0055128476,0.02984873,0.07313953,-0.09482158,-0.012411066,-0.027604826,-0.06786099,-0.08134814,0.031343006,-0.034903366,0.0055029034,0.047635864,0.025346147,0.08561194,0.069299914,-0.033898786,0.09742757,0.028891925,-0.056247473,0.05922845,-0.111214876,-0.027948786,0.049526297,-0.00039597147,0.022873202,-0.04663648,0.05720983,0.023243394,0.048503596,-0.082036875,0.0022441172,-0.10225246,0.05593403,0.09079965,-0.03885078,0.031089189,0.05045297,0.047358204,-0.009144826,0.05299086,0.108044036,-4.247953e-08,0.01781636,-0.061179016,-0.039394267,0.01374821,0.047299933,-0.015354293,0.04194542,0.016410599,-0.0317662,-0.03485476,-0.014396976,0.049358096,-0.0100265555,0.046596393,0.07056792,-0.009586539,-0.033366095,0.0569381,-0.03237509,0.052372217,0.012133238,-0.009781594,-0.05368369,-0.038468953,-0.045824602,-0.09489761,-0.0251348,-0.002882327,0.014606249,0.014468542,0.03906052,0.07742906,-0.07088957,-0.06830318,-0.083681494,-0.0139959315,-0.017478148,-0.07291407,-0.06726104,0.008474313,-0.03523173,0.0004247225,-0.023452338,0.023629861,-0.03474206,-0.04640897,-0.04983954,0.0134983715,0.005890533,0.07346666,0.07350328,-0.023630302,-0.0065099667,-0.059617285,-0.106255464,-0.040876687,-0.034339268,-0.02560432,-0.033885147,-0.07446371,-0.0016833312,-0.027597237,0.18557687,-0.054923333 +1.3.1.101,"A flavoprotein (FAD). The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase.",384,0.99999994,-0.10514447,-0.028242748,-0.16460115,0.012398108,0.04771499,0.032948095,-0.033867568,0.03616398,0.074143216,-0.056338,-0.010813237,0.020985937,-0.10733581,-0.036721632,-0.07612828,-0.02508845,-0.06662839,0.0003596596,-0.06479013,-0.040576495,0.06421529,0.005168939,0.02822483,-0.013765732,0.03263404,-0.043802436,0.009958164,-0.058405038,-0.049018454,0.024098976,0.027774923,-0.00052377617,0.12055312,-0.024666645,-0.03127393,0.0767903,0.029617188,-0.023164382,-0.031227732,0.026667722,0.077441536,-0.02870794,0.027646836,-0.024668315,0.048707373,0.025776867,-0.034638,0.033362985,0.026025018,0.051053274,-0.013683546,-0.06316456,-0.11311647,0.0076561472,-0.02052727,0.09248706,-0.016588604,-0.0630276,-0.0055968845,0.016854607,0.044176925,-0.01750534,0.029325897,0.058992196,0.013292636,-0.10698439,0.03268527,-0.050989497,0.043604597,-0.020127114,0.019829402,-0.015488438,-0.04675528,0.006818949,-0.009503021,0.07641522,-0.051730353,-0.0075122193,0.06447857,-0.01732628,0.12848325,-0.076707706,0.019086532,0.1026783,0.018385261,-0.018040255,0.005507508,-0.006976144,0.016023902,0.06995131,-0.011653486,-0.029636256,0.014682307,0.03311984,-0.08928518,0.06544876,0.053537305,-0.061676797,-0.037951265,-0.056577325,-0.04388758,0.00039058644,0.058601253,-0.03645284,-0.01912074,-0.041353464,-0.09052363,0.01856793,-0.01514553,-0.010756582,0.034570582,-0.03387362,0.08184683,-0.029725086,0.008146709,0.028784396,-0.029923763,-0.070916824,-0.045885716,0.027423905,-0.0790365,0.057121903,0.027642211,0.09054789,-0.0038810472,0.023175418,-0.10235117,2.5579361e-33,0.07246313,-0.0020936688,-0.044511337,-0.007754942,0.03527809,-0.037450597,-0.06565391,-0.051019896,-0.0011011956,-0.034704193,-0.022118889,-0.043417625,0.024620704,-0.025225569,0.0076875775,0.060859032,-0.012312699,0.0035387161,0.05641373,-0.084547475,-9.76784e-05,0.06598769,0.014681474,0.0017246011,0.056194767,0.013863461,-0.06218638,-0.0062722596,0.041252814,0.014207996,0.006757462,-0.12837945,-0.09813621,0.029112767,0.039766375,0.04101841,-0.06571961,-0.09812347,-0.08784448,0.04953587,0.007299881,-0.021662919,-0.015820555,0.016761387,0.03621298,0.020521972,-0.10378475,0.11195811,0.053599782,0.073545285,-0.011382478,0.007605,0.10960032,0.10244132,-0.08234262,-0.020729082,-0.031065026,0.028443724,0.017525919,0.001989755,-0.006809245,0.09736591,-0.032759428,0.086084425,-0.018964723,0.026879475,-0.05662618,-0.058464367,-0.0064441217,0.07276531,0.064182095,-0.034481395,0.028312838,0.03962987,0.03144679,-0.02369589,0.02942931,-0.006712466,-0.079044916,0.02149156,-0.0083221635,0.024575004,0.027682599,-0.014420719,-0.046040133,0.035708483,-0.018163415,-0.030418456,0.009427039,0.054851826,0.019070057,-0.050686136,-0.009175024,0.0907768,-0.012432631,-2.2256408e-33,0.03369985,-0.14660956,0.069958776,-0.03955847,-0.013606754,0.062349454,0.011789341,-0.0012400475,0.0379598,-0.022728804,-0.014150832,-0.032701295,0.020046914,-0.023142252,0.04933066,0.0063053076,0.015896607,0.043723106,0.029537028,0.009863953,-0.060016382,0.030488247,0.0007058472,0.10485347,-0.014514046,-0.03351523,0.02295327,-0.026434822,-0.04943298,0.025681984,-0.0057030567,0.005662132,-0.10138302,-0.027650543,-0.084878616,0.02418163,0.01097545,0.042027544,0.032466322,0.019842638,0.0076557724,0.011772813,0.022663848,-0.004717576,0.078535505,0.01130925,-0.03378207,0.051770404,0.032428082,-0.031190097,0.026439553,-0.0028207302,0.008871804,0.09760637,0.08312716,0.031415615,0.050542336,0.08108513,0.0017465507,-0.056543827,-0.02126705,-0.14354335,0.036107052,-0.016686575,0.085683174,0.15883574,0.047840774,0.05962722,-0.0064271344,0.025949338,0.12793916,0.0270357,-0.014867455,0.08312858,0.049840268,-0.030025983,-0.037147827,0.01479587,0.01805388,-0.010945341,0.008496857,0.0270346,0.054297093,0.021304915,-0.018690942,-0.11960015,0.0488396,0.08584373,0.0010000521,0.026789444,0.01078001,-0.023704423,-0.05449977,-0.038791876,0.07456017,-4.2611614e-08,0.052150384,-0.028612327,0.031872984,-0.062004063,0.050125264,0.008425481,0.031545807,0.0026914345,0.014630561,-0.07121873,-0.07391257,0.12856238,0.035208154,-0.011174606,0.024163507,0.013455708,-0.046979908,0.04197331,-0.010796401,-0.071299374,-0.032781858,-0.016858855,-0.071668535,0.027756458,-0.018498883,-0.005186718,0.0015847455,-0.01576467,0.047816917,-0.03567013,-0.022898199,-0.024993857,0.006300761,-0.02472802,-0.055105913,-0.01027455,0.05215721,-0.07413396,-0.043433208,0.03945177,-0.042482506,-0.0096768085,0.047349326,0.00032821187,-0.05566921,-0.019372767,0.027210403,0.03432198,-0.031370975,0.032081343,0.030518075,-0.0052891676,-0.0014945134,-0.048143823,-0.14621025,-0.12208708,0.02318993,-0.06080199,-0.039619077,0.01166748,0.016691197,0.030022126,0.13702592,0.015238025 +1.3.3.13,"A flavoprotein from the bacterium Streptomyces noursei. The enzyme can also oxidize several other cyclo dipeptides, the best being cyclo(L-tryptophyl-L-tryptophyl) and cyclo(L-phenylalanyl-L-phenylalanyl) [1,2].",384,0.99999994,-0.06398499,-0.0132699665,-0.14535832,0.02620479,0.07116757,0.017988194,-0.010942396,0.053089295,0.050508887,-0.09095904,0.020636894,0.009950772,-0.020584809,0.10528095,-0.10967839,0.049946588,-0.035023786,0.03022184,0.011051989,-0.010842945,0.029440345,0.066592306,-0.0039704395,0.022105252,0.018400306,-0.023535537,-0.04307154,-0.025016028,-0.05310519,-0.078416795,0.043512683,0.087635376,0.035320397,-0.0473526,0.059626687,0.026168652,-0.04533757,-0.05604916,0.07238878,0.014125678,-0.010355673,0.009121872,0.03023627,0.033232395,0.0027667796,0.049011197,0.0479521,0.112497345,0.057412393,0.02985081,-0.047109358,-0.06953258,-0.091783814,0.041761212,0.01762715,0.04259915,-0.06841019,-0.040142335,0.034603395,-0.03602515,0.0005650195,0.019375123,0.07137498,0.044445544,-0.06543909,-0.039983165,-0.0142919505,-0.057444904,0.029343713,-0.035238136,-0.040316388,-0.0600144,-0.034017548,0.05053185,-0.0054458966,0.099676915,0.0061512985,-0.005346031,0.009648143,-0.0059314044,0.06916259,-0.044715926,-0.014425266,0.11874938,0.06934249,0.00054877816,-0.033340868,-0.00921358,0.029130097,0.01736411,0.036567353,0.038665608,0.0139206825,-0.054326072,-0.045254946,0.027434789,-0.018215997,-0.05601929,-0.066463634,0.014767909,-0.018607713,-0.021534096,0.012811325,-0.019173106,-0.0356784,0.0042572212,0.007481599,-0.001897081,0.023823617,-0.058325466,-0.025970124,-0.002415589,-0.0054706577,-0.13334475,0.032562286,0.033482,0.08252062,-0.050248526,-0.11668799,0.014457716,-0.020079061,0.013422726,0.004093189,0.06594359,-0.0038351906,0.08172581,-0.09076336,4.4466486e-33,0.05986743,0.047382604,0.0702843,-0.03489193,0.035925582,-0.030424066,-0.01098131,-0.0005646445,0.035039887,-0.05969496,-0.111465365,-0.048702195,0.03249791,-0.0329655,0.0691954,0.01195259,-0.019082632,0.003222709,0.046508417,-0.029032728,0.010339367,0.030809538,-0.029169416,0.011998551,0.037067566,0.05981698,-0.007209108,-0.047663335,0.067142226,-0.0173987,-0.0019662306,-0.0554574,-0.12785473,0.0016614653,0.043515068,-0.034826003,-0.106834464,-0.08415001,-0.02192722,0.08565707,-0.08949478,0.019386318,-0.011717363,0.0138891665,0.074150495,-0.062031545,-0.0722397,0.08461009,0.007315607,0.0552606,0.049474645,-0.04761482,0.08999976,0.05198836,-0.116504274,0.042344913,0.027350316,0.03185139,0.03938857,0.007952581,-0.041202985,0.047052972,-0.06691633,-0.031611566,-0.012974235,0.026754221,-0.050751317,-0.05684879,-0.049481656,0.033953045,-0.018116059,-0.024473164,0.061440926,0.020526057,-0.009665936,0.017229585,-0.07810407,-0.0051052785,0.05530004,0.012768914,0.015833799,-0.062966906,-0.010044401,-0.036889546,-0.029109715,0.05184611,0.02639602,-0.07870705,0.010327786,0.037389025,0.020717345,-0.08259667,-0.0188299,-0.033014886,0.031806186,-4.2594155e-33,0.10184871,-0.15042777,0.045878362,0.0006709109,0.0054639913,-0.00544756,-0.040404867,-0.05213084,0.0046499777,-0.058989912,0.012687347,-0.07114619,0.030876463,-0.029640852,0.047299527,0.01255321,-0.009115517,0.1509863,0.017669016,0.030018242,-0.022983396,-0.01282079,0.091980115,-0.01391513,0.07293648,0.016921531,0.019429184,0.0080784,0.04668427,0.026284928,-0.06483787,0.029360067,-0.01606434,-0.08206221,0.021153927,0.08734368,-0.08280718,-0.0065897126,0.084991254,0.017308611,0.045312136,0.020038582,0.073477715,0.04085577,0.05127385,0.07686366,-0.105139375,0.02999552,0.074782975,-0.027104417,0.033236608,0.044638827,-0.056840215,0.07752917,0.080907576,0.03966806,0.060484856,0.032874383,0.003042522,-0.008667551,-0.04539346,-0.09096223,-0.046832286,0.012679489,0.06801282,0.072794765,0.01281175,0.08979752,-0.012522717,-0.024643958,0.07468166,-0.039979003,0.055646285,0.019524742,-0.031032752,0.004027471,-0.036577206,0.033286396,0.0019993428,0.0011193606,0.016716635,-0.051552404,0.02476572,0.004344284,0.0012949816,-0.11697486,0.01188454,0.014684486,0.050049707,0.01500189,-0.048055932,0.025949927,0.060482353,-0.00240651,0.056786858,-4.1694715e-08,0.059768092,-0.05572927,0.054364566,-0.04135646,0.07713188,-0.029804375,-0.013551202,-0.047460005,0.0026993658,-0.04445044,0.05397978,0.05851445,-0.010077343,-0.05903844,0.039342523,0.009307779,-0.04160531,-0.028690917,0.021955762,0.0101034,-0.08885404,0.020312428,-0.07204926,0.019475022,-0.014302129,-0.06212103,0.09933715,-0.03673814,0.07929952,-0.019566216,0.0019764735,-0.013386022,-0.0061740438,-0.053495277,-0.09774574,0.0030246733,-0.05792444,-0.035516985,-0.011473336,0.038739644,-0.09560887,-0.034529243,-0.07570597,-0.020669797,-0.03577085,-0.018743735,0.039854523,-0.014222629,-0.04930925,-0.04636064,-0.0011050365,-0.0119030215,-0.046145517,0.02485659,-0.07866908,0.0004801345,0.0598951,-0.011162172,-0.05045424,-0.089347534,-0.027712937,0.021188853,0.16974527,0.022578131 +1.3.99.33,The enzyme from the bacterium Shewanella oneidensis MR-1 contains a noncovalently-bound FAD and a covalently-bound FMN. It functions as part of an anaerobic electron transfer chain that utilizes urocanate as the terminal electron acceptor. The activity has been demonstrated with the artificial donor reduced methyl viologen.,384,1.0,-0.08880853,-0.017770458,-0.039832875,0.008722156,-0.018436108,-0.026374614,-0.01990425,0.07124641,-0.031984553,-0.00038011433,-0.009901194,-0.030522224,-0.049885232,0.048082363,-0.07568051,0.013658401,-0.055873476,-0.047327843,0.055624586,0.025242401,0.05223432,0.038913947,0.0044400273,-0.10457137,0.0015051261,0.018908048,0.03018536,-0.0012405143,0.011102125,-0.096081056,0.0052959616,0.02199577,0.03997266,-0.010621344,-0.005727129,0.11535532,0.01000491,-0.05537514,-0.0017714554,-0.029694883,0.059900064,0.013698342,0.116131,-0.078429595,-0.06844089,0.008529574,0.105129346,0.03733422,0.029266777,-0.04757773,0.042382758,-0.02869901,0.014308696,0.01448248,-0.017283425,0.04973476,-0.038120355,-0.04427598,-0.06432559,-0.012954027,0.007139032,0.050579768,0.036466856,-0.019441152,0.077852145,-0.07417042,-0.019213378,-0.088047534,0.0004076311,-0.021581769,-0.040341128,-0.07064742,-0.0026769543,-0.044318393,-0.034025934,0.06476276,-0.011815192,0.010501596,0.055044428,-0.03018921,-0.034747954,-0.09934507,0.04422394,0.062193405,0.0136582395,0.020664971,0.028605834,0.042289976,0.029759841,0.016549246,0.0150156645,0.005381098,0.007730508,-0.038083248,-0.091019,0.0024627538,0.008408235,0.042822048,-0.018722758,-0.004566102,0.03162294,0.14268833,-0.019678963,0.0064722616,-0.024480708,-0.038938913,0.05552206,0.07042702,0.06150497,-0.03680827,0.045668617,0.02833539,0.037706077,-0.056166988,-0.11166075,0.0378889,-0.057445392,-0.09140306,-0.040914163,-0.043050718,-0.075691275,-0.021888148,0.002959699,0.06608304,-0.013911046,-0.020448312,-0.11969731,1.9120817e-33,-0.003405324,0.019967254,-0.0012166514,-0.06265617,-0.03942662,-0.015639134,-0.007945393,-0.033338852,0.012885198,-0.06912087,-0.11221086,-0.04509021,0.07980051,0.0006305163,-0.08461912,0.0077053835,-0.018915204,-0.04857799,0.088594235,-0.018405838,0.09034283,0.07638163,0.015813414,-0.033017516,0.05386855,-0.029766452,0.03208168,0.049603693,0.051072575,-0.013437119,0.026027635,-0.006971621,-0.110556304,0.0059522027,0.023186693,0.029088845,-0.05134773,-0.012627277,-0.0011247876,0.053780504,-0.009061578,0.0719287,-0.025615258,-0.0008130756,0.057508823,-0.066514276,-0.03203152,0.027159229,-0.0068087736,0.06647386,-0.017990721,-0.04508114,0.04701192,-0.06665868,-0.08242387,-0.025818473,0.06040708,0.046978734,0.0068335505,0.059415627,0.0089468835,0.072217464,-0.03902241,0.079832904,0.019418405,0.080445684,0.0535361,-0.07551737,0.013578125,0.09304603,-0.07697099,-0.038426224,0.057079222,-0.043239262,-0.006579916,0.012586091,-0.056655057,-0.036530197,0.04217156,-0.017887572,0.0634595,-0.09399376,-0.004540272,-0.05356033,-0.029702155,-0.05454406,-0.021327382,-0.07196584,0.02113318,0.0048254766,0.15649919,-0.048448212,-0.021197109,0.034869373,0.023330856,-2.7255065e-33,0.014162583,-0.03131069,0.07947359,-0.039781302,-0.033081193,0.101562224,-0.011249378,-0.015388799,-0.014761817,0.012682962,0.07529619,0.045899615,0.02193403,-0.08566963,-0.0072231046,-0.016014306,0.016412763,0.014863061,0.02161841,0.04309426,-0.09033937,0.09071584,0.019855035,0.038571168,-0.05773387,0.05986734,0.039295074,-0.0007456897,0.07132548,-0.027371565,0.02995653,0.04827295,-0.07305817,-0.091571055,0.0011603226,0.014073213,-0.0025495028,0.014545692,0.11022003,-0.0077216956,0.05658031,0.003297229,0.035045587,0.071040735,0.018599182,0.029994464,-0.18900202,0.0065001906,-0.012385,-0.058576122,-0.040110588,0.037000593,0.007145794,-0.04556247,0.09352712,-0.012637233,0.080889426,0.018199055,0.018082965,-0.006759707,-0.028596452,-0.07314236,0.06614478,-0.030659458,-0.04327492,0.03193186,0.031203154,0.07827138,0.007873319,0.04104524,0.061781183,0.044006143,0.06014477,-0.02593353,0.0013828122,0.057035442,-0.010602054,-0.06426177,0.040233552,-0.016570201,0.0408218,-0.010666575,-0.03408783,-0.09130046,0.06543817,-0.0742566,0.072897024,0.08497765,-0.009200328,0.0023756325,0.035207514,-0.01913173,0.010405146,-0.035397764,0.026621744,-3.8076774e-08,0.008622245,-0.091934614,0.030814512,-0.027469426,-0.0041074776,0.06508528,-0.06657982,-0.032935545,0.09816806,0.023554318,-0.038025007,0.09715246,0.0075117494,-0.020809064,0.03543502,0.013390408,-0.06629191,-0.009135224,-0.055478193,0.039030377,-0.09841006,-0.017891858,-0.086707346,-0.03379919,0.08498322,-0.04173354,0.069654204,-0.012241005,-0.04441872,-0.024976594,-0.03501555,0.04770744,0.0037824162,0.04012644,-0.089857645,-0.0026324403,0.09087614,-0.013519097,-0.07264846,0.012890599,0.06013238,-0.013733903,-0.050227173,-0.0044008344,-0.0330929,0.084449634,0.020259025,0.012083058,-0.09127589,-0.027102765,0.02411061,-0.041599955,0.0052329805,-0.08664638,-0.101066105,0.055041865,-0.061895978,-0.010570692,0.014012689,-0.0009934191,0.06054107,-0.017999824,0.07719058,-0.016042342 +1.3.99.34,"A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol 1-phosphate with comparable activity. Geranylgeranyl diphosphate is partially reduced to phytyl diphosphate with 10% of the activity (cf. EC 1.3.1.83, geranylgeranyl diphosphate reductase). Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], the enzyme shows no activity with NADPH. In vitro the enzyme can utilize sodium dithionite as the electron donor.",384,1.0,-0.06588043,-0.0016277212,-0.085549116,-0.034335483,0.057656217,0.013740282,-0.055027544,0.031569447,0.09007322,-0.06035008,0.0054680593,0.03098384,-0.064203896,0.013882119,-0.038444523,-0.016038613,-0.003079634,0.015579347,-0.022426425,-0.025124889,0.06690223,-0.016207559,0.020017382,0.002148936,0.046169918,-0.013862281,0.04458885,-0.072937034,-0.092666246,-0.03993425,0.030195028,-0.090877,0.07850313,-0.05729093,-0.0051838364,0.089324914,-0.011124826,-0.011426997,-0.006950296,0.020859968,0.065915994,-0.0107845785,0.02791539,-0.03756714,0.015992092,0.01393584,-0.010230802,0.025740504,0.008440157,0.012511105,-0.046244197,-0.018972203,-0.06487874,-0.011386347,0.045486268,0.030239277,-0.045240074,-0.02215691,-0.030496286,-0.014572778,0.045639098,-0.039714996,0.027763112,-0.020910637,-0.03199094,-0.07892888,0.08595243,-0.050443713,0.090697475,-0.0015437212,-0.05021019,0.00026583415,-0.003110158,-0.0028697117,-0.043086383,0.07943643,-0.0321065,0.04781245,0.054033726,-0.050592694,0.08809978,-0.0712671,-0.0045083202,0.071944065,0.04853477,-0.024703689,-0.041104786,0.035600916,0.025351394,0.03375844,0.051413566,-0.013261523,0.051046915,-0.013406041,-0.11330552,0.056742493,0.016488517,-0.024048038,-0.081485756,-0.018017614,0.029034752,0.056366134,0.041508056,-0.08597448,-0.047411986,0.010639823,-0.042970512,0.099994905,-0.029604506,-0.0063227997,0.01057971,-0.03711181,0.0705513,-0.011522351,-0.038821716,0.06629729,-0.0035177472,-0.06107794,-0.1040288,0.0604448,-0.0355296,-0.00608891,0.085488684,0.076602556,0.03160484,0.047104374,-0.11601041,7.448342e-33,0.10719961,0.030561268,-0.016486157,-0.01890327,0.0018461529,0.0006661665,-0.060581304,0.053219397,-0.031992733,-0.046272065,-0.014712808,-0.08894171,0.0664423,-0.029989736,-0.049567353,0.025615986,-0.007506042,-0.02173593,0.11221419,-0.07208445,-0.013998545,0.05128685,-0.013166938,0.007881973,0.07744844,-0.047412813,-0.071818665,-0.01682862,0.03020833,0.0032940088,0.044079483,-0.16747917,-0.117273495,0.013714053,0.048004992,-0.005849754,-0.07075766,-0.08209744,-0.056398306,0.027209882,-0.06574974,0.022505235,0.017008815,0.0040242937,0.052291043,-0.014617951,-0.061927214,0.11011838,0.05379882,0.104475066,0.034847964,-0.055323847,0.11440767,0.071723655,-0.10735596,0.0045801275,-0.023631023,0.016657835,0.034288917,0.05858904,0.034050196,0.07494967,-0.056955844,0.007377216,0.031065674,0.058565382,-0.06611658,-0.02789246,-0.0015827271,0.09353501,0.06817779,-0.040329747,0.07378729,0.0832704,0.009794196,-0.028097665,0.00014005949,-0.021272546,-0.01722585,0.038165584,-0.0045321602,-0.017521555,0.025205327,-0.022804128,-0.067494206,0.06918897,-0.010702426,-0.072829284,0.03449419,0.0480385,0.05078123,-0.060034405,-0.038727805,0.01931385,-0.02681486,-5.0039424e-33,0.07891929,-0.10610543,0.039091066,-0.048589833,-0.024233162,0.062116724,0.036974926,-0.040083285,0.014330461,-0.10373373,0.050168812,-0.023784379,0.04252364,-0.004361142,0.0006873602,-0.0041516894,-0.013435232,0.060353085,0.046833646,0.03627989,-0.0134073235,0.029111939,0.041111298,0.095092475,0.01386644,-0.014157625,0.029587675,-0.010156667,-0.0039168983,0.08376527,0.0005659662,0.043322045,-0.10303996,-0.055798415,-0.08084342,0.012042519,-0.0490613,0.035258863,0.008704994,0.024769945,0.0057320483,0.03519948,0.016251227,-0.02087104,0.071933694,0.09445564,-0.055728495,0.064950034,0.026662637,-0.060092635,-0.024462076,0.027378274,-0.007433096,0.08837375,0.1051775,0.033439245,0.06096261,0.041373547,0.012899631,-0.040735163,-0.040114585,-0.09938231,0.009944617,-0.04311503,0.09387963,0.14771535,0.054428864,0.10403465,0.007251664,-0.01447366,0.047787618,-0.019173456,0.049930528,0.044774346,0.005891736,0.03325168,-0.02320857,-0.0035642139,-0.018994495,-0.030415855,0.06175663,-0.0070929457,-0.014946093,-0.08525057,-0.048026383,-0.056633096,0.05667759,0.07655666,-0.0032856863,0.044822715,-0.02249439,0.02079131,-0.021688608,0.011248281,0.08495243,-5.2192693e-08,0.045197416,-0.01536089,0.034497697,-0.048547603,0.01554311,0.047513653,0.038065717,-0.0022019777,-0.007973294,-0.035673708,-0.046354163,0.09100438,-0.023446366,-0.028547216,0.017439136,0.007440479,-0.038335625,0.033977587,-0.037588228,-0.06379122,-0.019429516,-0.010467461,-0.13639683,0.05008817,0.028213583,-0.05627677,0.009968771,-0.019797927,0.05516894,-0.09330626,4.9240305e-05,-0.023838723,0.05142581,0.018549815,-0.031438056,-0.0155931525,-0.050536107,-0.0155529585,-0.031000605,0.078580126,-0.078571476,-0.03410724,-0.026944233,0.015357298,-0.0051335003,-0.0054180785,0.042412985,0.036546245,-0.07618995,-0.0011853576,0.04080492,-0.0057786913,0.030365376,-0.067329235,-0.117605336,-0.044450194,0.0069450047,-0.038739495,-0.035926767,-0.017563973,0.039346747,-0.028160213,0.08512051,0.012970014 +1.5.1.47,"The enzyme, characterized from the bacterium Methylobacterium extorquens, is involved in biosynthesis of dephospho-tetrahydromethanopterin. The specific activity with NADH is 15% of that with NADPH at the same concentration [1]. It does not reduce 7,8-dihydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase).",384,1.0,-0.0033266766,0.032675754,-0.11299018,-0.06496,0.027701389,0.022587411,-0.033492148,0.09470176,0.026045112,0.023724707,0.0022094806,-0.049140163,-0.048180994,0.009938151,-0.05149493,0.053810533,-0.065467,-0.009719537,-0.036748983,-0.03384373,0.052693546,0.0072623296,-0.016607057,-0.014330972,0.021357985,0.0037228314,-0.012043986,0.004142845,-0.026543885,-0.025818989,-0.02420639,0.037497897,-0.010679697,-0.04630129,0.052651756,0.14233434,-0.030332409,-0.01637159,0.0015436577,0.03531835,0.049875174,0.015790908,-0.08290427,-0.0013610328,-0.06470965,-0.004559212,-0.017515628,0.106360145,0.012315802,-0.0024186296,-0.07434409,-0.045629635,0.009512631,0.06390709,0.07526175,0.009117213,0.06289625,-0.005302277,-0.07747841,-0.069823235,0.007418582,-0.05102909,0.0037691933,0.017671922,0.028725894,-0.04789573,0.08725383,-0.12730777,-0.038242377,-0.06631239,-0.0800255,0.0018747536,0.025698425,0.035865925,-0.06135346,0.060702223,-0.02276782,-0.00792502,0.024502655,-0.026645575,0.086502776,-0.014724833,-0.00088667485,0.021555688,0.04221755,-0.01489772,-0.046019506,-0.08027241,0.05188229,0.045618072,0.0028174252,-0.030475883,-0.012428626,-0.06666743,-0.107213646,0.028560102,0.01782092,-0.044191465,0.020000402,-0.014776832,-0.007543102,0.089388974,-0.05635908,-0.07224852,-0.080741584,-0.0017342722,-0.0048694746,0.10685568,-0.034273416,0.028619403,-0.015672056,-0.0361534,0.0670685,0.02867996,-0.04914858,0.11929382,0.07372568,-0.02839132,-0.07176531,-0.050490916,0.00520311,0.013123973,0.07319027,0.06039683,-0.015579036,0.014148453,-0.16643058,2.4794693e-33,0.122743644,0.004641216,0.0040804343,-0.01803807,0.09108152,0.035564516,-0.09366376,0.082085006,0.057845056,-0.05994282,-0.06743506,-0.08070968,0.07142236,-0.018964969,0.03967156,-0.028029626,-0.017191008,0.014371521,-0.007801462,0.002489437,0.035660043,0.052377082,-0.063554354,0.011574162,0.01409267,0.11779285,-0.046912722,0.034704052,-0.00060036447,-0.02157404,0.049209252,-0.069509074,-0.108295746,-0.026898833,0.111746974,-0.046550833,-0.053525507,-0.0006238267,0.021593347,0.048302427,-0.015484096,0.0016245665,0.021372115,-0.037475683,0.030240376,-0.06891256,0.011097097,0.010016575,0.06948421,0.035272744,0.07570521,-0.015001118,0.08834526,-0.073019944,-0.06553464,0.0026685318,-0.028571146,-0.04879767,0.035041936,0.08066574,-0.009637469,0.01146803,-0.029857459,0.030039415,-0.03469858,-0.060712527,-0.061184548,-0.07779521,-0.012763027,0.06544598,-0.030305713,0.024442596,0.115745656,-0.011789433,0.02558018,-0.0024892427,-0.004522972,0.005283432,0.004707862,-0.045943066,0.0060549155,0.015596685,-0.01861967,-0.06609111,-0.024917059,0.05711355,0.0029043732,-0.035882585,-0.022069985,-0.012946758,0.063835144,-0.06520861,-0.09788867,-0.05382222,0.027273322,-4.2182358e-33,0.054161612,-0.04226905,0.055764366,-0.11704812,0.025630375,0.10530309,0.014015524,0.006069533,0.031339403,-0.0980618,0.044782136,0.0512998,0.041071266,-0.008063588,0.0012791331,0.00865328,-0.0062825833,0.082083836,-0.012767297,-0.06170401,0.051290512,0.055399224,0.02005638,-0.031924076,0.08558224,-0.0913631,-0.05461705,0.07540944,0.041969053,0.015657412,-0.019811962,-0.0070385523,-0.04645267,-0.027919926,-0.02792546,0.073768966,-0.1441955,-0.0044234646,0.016771633,0.06268338,0.02769816,-0.037020244,-0.019844491,0.013737924,0.024167428,0.060390417,-0.11904562,-0.061085407,0.06809529,0.011910571,0.08340567,0.0077013224,-0.0024942856,0.056067422,0.080072574,0.04994327,-0.01213166,0.027352124,-0.053740337,0.034488015,0.0405822,-0.02879643,0.022272943,0.03498565,0.028505746,0.04592419,0.016461017,0.061503753,0.079920195,-0.028807186,0.10894641,0.02434853,-0.0046328004,0.07582358,-0.015378559,-0.10289024,-0.077665284,-0.0040372075,-0.054372936,-0.0042750216,-0.04721016,0.01914789,-0.008169663,-0.05783732,-0.03547644,-0.008808443,0.036342226,0.018946547,-0.0531119,0.048630673,-0.009463642,0.023801042,-0.04494272,0.06392011,0.012891757,-4.1572395e-08,0.025676696,-0.066553034,0.014367462,-0.08145049,0.039071064,0.009963814,0.03503778,-0.012360282,-0.0036444867,-0.029150028,0.041929927,0.069892354,0.020910699,0.029584274,0.06496138,-0.005816774,-0.0228763,0.013375133,-0.011144043,-0.012868919,-0.022442155,-0.01201046,-0.10142601,0.051061556,0.038423527,-0.024036493,0.0034798866,0.022441866,-0.026117694,-0.05777421,0.026442496,0.03341919,0.033862166,-0.036622323,-0.0785036,0.015290805,-0.08792251,0.013838527,-0.06556652,0.06340167,-0.004215283,-0.04464962,-0.019124148,0.05815911,-0.011159427,-0.0040472583,0.007128746,0.009132288,0.012775388,0.0030322585,0.06291313,0.048975054,-0.0056818407,-0.043824106,-0.10328179,-0.010744951,-0.025940562,-0.039916348,-0.05755317,-0.027015727,0.08910165,0.009530963,0.14057122,-0.03296645 +1.7.1.15,"An iron-sulfur flavoprotein (FAD) containing siroheme. This prokaryotic enzyme is specific for NADH. In addition to catalysing the 6-electron reduction of nitrite to ammonia, the enzyme from Escherichia coli can also catalyse the 2-electron reduction of hydroxylamine to ammonia. cf. EC 1.7.1.4, nitrite reductase [NAD(P)H].",384,0.99999994,-0.072516166,0.014035395,-0.06569552,-0.02474565,0.059833463,0.04402967,-0.027104387,0.019547949,-0.01605478,-0.01824452,-0.042116,0.022587607,-0.1058598,0.008378734,-0.075294,0.028229425,-0.05995559,-0.0147116445,0.002449008,-0.032955363,0.0438525,0.024307067,0.063847244,-0.07348722,0.07030048,0.033084586,0.036324564,-0.058166478,-0.019784538,-0.03727142,0.032118093,-0.0041249087,0.013890916,-0.06559577,-0.0081983255,0.061110083,0.03363809,0.019778052,-0.0014533965,-0.00146027,0.021390269,0.009468551,-0.032008097,-0.060712773,0.025844652,0.0450011,0.03234773,0.063697055,0.022067122,-0.0046351845,-0.036538064,-0.041610748,-0.01743688,0.0483756,0.08077343,-0.001479857,0.0020450542,-0.08237744,-0.012698689,-0.002595757,0.02946875,-0.043680035,-0.041587777,-0.020132888,0.0845202,-0.07046665,0.01919922,-0.067313276,0.022647388,-0.07147041,-0.03705432,-0.018726414,-0.03182711,0.02513098,-0.034667134,0.038642593,-0.016160881,-0.06594336,0.09071489,0.018009396,0.050514575,0.052323837,0.07112772,0.09794391,0.06943151,-0.009382813,-0.032496303,-0.010175961,-0.03316065,-0.016509013,-0.039489463,-0.044965286,0.035825104,0.02506098,-0.12573645,0.04234823,0.027594106,0.002960982,-0.007997241,0.001695038,0.018984785,0.08730884,-0.043883905,-0.06973091,-0.1096509,0.01856775,-0.020048816,0.17789619,-0.020627545,0.0068087033,-0.024121925,-0.021057596,-0.03017333,-0.029226726,-0.063269086,0.073608145,0.02689939,-0.016376141,-0.10456487,-0.010773221,-0.015599863,0.097399816,0.031269256,0.072742224,0.022689229,0.0191464,-0.13828056,3.2194527e-33,0.10397482,0.04738209,-0.03470073,-0.06869625,0.04024688,0.023030438,-0.07863491,0.022909539,0.06529781,-0.046391252,-0.0035500615,-0.05922631,0.024970006,-0.09630602,0.008022208,-0.007017075,-0.02623101,-0.028539745,0.0676231,-0.043719597,0.023638261,0.10430763,-0.014164603,0.02393708,0.005483502,-0.025022807,-0.043129064,0.03601465,-0.0032529614,0.00066728867,0.054570038,-0.08011907,-0.10438102,0.03091298,0.02737082,-0.019452054,-0.11280487,-0.06308908,-0.06219906,0.07181433,-0.085842535,0.03935858,-0.020284064,-0.0322865,0.0431985,-0.09797876,-0.027103314,0.068290845,0.034771174,0.061981577,-0.0052904505,-0.009106824,0.101356715,0.002408723,-0.04812208,0.011362781,0.02079062,-0.0011930416,0.020246193,0.058460075,0.019972362,0.026916184,-0.0070644,0.09583341,-0.0775773,-0.025667911,-0.024100026,-0.06870573,0.018994013,0.135283,-0.0505817,0.0759809,0.11496285,0.00897928,0.02960595,-0.09002762,0.00065860664,-0.05515391,0.034483407,-0.007661254,0.049087007,-0.024294034,-0.013185085,-0.022421287,-0.0012593033,0.0068512224,-0.023012672,-0.056598827,0.0060912627,-0.018074222,0.0368072,-0.08850578,-0.06318092,-0.03969831,0.014562199,-3.3112666e-33,0.06888592,-0.038125165,0.010743119,-0.06790836,-0.026859293,0.061146244,0.07196375,-0.039803058,-0.03351903,-0.036655147,0.055510134,-0.022524254,0.05641062,0.023024404,0.04131541,-0.008106263,-0.027776714,0.014500205,0.056937214,0.03132264,-0.019180417,0.072787784,0.012848244,0.0006963224,0.056339104,-0.06338326,-0.017654892,-0.015583944,0.10090457,0.027842127,-0.047401898,-0.004790869,-0.0885638,-0.07585565,-0.009930126,0.03204809,0.011767967,0.03218836,-0.026494142,0.046947904,0.011222031,-0.013661353,-0.011980154,0.05768421,0.040412113,0.079015434,-0.15399618,0.039670978,0.05878844,-0.044933226,0.0550362,0.015566701,0.011709182,0.036618806,0.0618697,-0.019425124,0.055227667,0.03325448,0.032863352,0.041280217,-0.03504619,-0.097765684,0.036155917,-0.008397522,0.071162894,0.026564907,-0.0068684043,0.09739644,0.0028138903,0.023951555,0.044107135,-0.0052811136,0.08051563,0.0599008,0.008040458,-0.0899953,-0.0009718535,0.024408177,-0.008406755,0.002618716,0.08106459,0.02466304,-0.008074444,-0.03757176,0.006958449,-0.04542266,0.053878464,0.09965426,-0.0508413,0.03141564,0.0020113941,0.06771772,0.009391818,0.016875768,-0.02756513,-3.789295e-08,0.041985713,-0.094640434,0.0059907,-0.03635778,0.0507589,0.017658072,-0.023818443,-0.035531368,0.0077055753,-0.026334526,0.0042190785,0.16124201,0.031373627,-0.01104221,0.0350955,-0.039037216,-0.047430146,-0.006403785,-0.026389007,-0.0045940448,-0.061792474,0.029713755,-0.13980067,0.06149841,0.00238125,-0.030246357,0.044861883,-0.049842644,0.006754079,-0.07452746,-0.026153719,0.04268763,0.08602262,-0.050163157,-0.094659775,0.029284822,0.015718054,-0.0046975412,-0.027256554,0.0018281282,-0.03919779,-0.01582152,-0.044123843,0.023570303,0.046169866,-0.0058105737,0.0043072384,-0.022947103,-0.058214575,0.0034719366,0.036285322,-0.02869535,0.06333638,-0.074913494,-0.10985165,0.04944024,-0.02956432,-0.109457664,-0.015440703,-0.044445515,0.056218244,-0.0062662764,0.10488759,0.0015951528 +1.13.11.74,"The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent). The enzyme also has some activity with 2-amino-5-methylphenol and 2-amino-4-methylphenol [1]. The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.76, 2-amino-5-chlorophenol 1,6-dioxygenase [2].",384,0.9999999,-0.08416799,-0.034790643,-0.07849342,0.018377826,0.09131048,0.00577885,-0.043330863,0.020794734,0.02368118,-0.07548186,-0.035048347,-0.10714804,-0.030509762,0.036682677,-0.051403005,0.008442092,-0.02249366,-0.05581247,-0.0055752518,0.021619644,-0.027488954,0.04382085,-0.021340491,0.0055641104,-0.035151467,0.029614564,0.09525141,0.026080986,-0.06177537,-0.039097186,0.021925913,-0.031070784,0.048633944,-0.021411203,0.05054821,0.056277044,-0.0048260544,-0.08156047,0.07206401,0.023922842,0.0076298406,0.07661543,-0.023681631,-0.055638973,-0.034272764,-0.054062273,0.04665892,-0.004672884,0.03383479,0.015728904,-0.038674474,-0.04606048,-0.013259595,0.06927003,0.03734054,0.041213263,0.030096766,-0.030886393,-0.068315305,0.0014383562,0.018341994,-0.034594674,0.04539468,0.016324164,-0.06496491,-0.008158285,0.009204391,-0.07098363,-0.024462167,-0.12941757,-0.082075946,-0.05233014,-0.034889583,0.019646542,-0.04459691,0.021125315,0.052916583,-0.026271338,0.09763882,-0.0774018,-0.05868331,-0.037523605,0.060539983,0.10336441,0.058930676,-0.0017484479,0.021233106,-0.032300368,0.03369309,0.07306261,0.014876852,0.020371275,-0.019764688,-0.06568888,0.0043898793,0.017565327,0.036882833,0.067616895,-0.009380085,0.007651729,-0.019220423,0.05083582,-0.05177963,-0.079753034,-0.033494674,0.00740371,0.0335944,0.083859175,0.05586083,-0.040297862,0.036820702,0.005977795,0.07345073,-0.0016856432,-0.0093623325,0.0412985,0.09667077,-0.025119852,-0.069048636,0.031814244,0.08576561,-0.06115592,0.062231448,0.027169148,-0.07780977,0.03958347,-0.097148396,4.060611e-34,0.049152028,0.015106839,-0.015380752,0.0022485917,0.008132917,0.042583566,-0.104735635,0.021747962,-0.07070753,-0.043304063,-0.049967043,-0.011618726,0.040951084,-0.038675353,0.0059775184,-0.03077979,-0.038370866,-0.014915099,0.0682555,0.00637356,0.05012122,0.05686392,0.0017070695,-0.0053592166,0.025323095,0.07000061,-0.018167013,0.020767521,-0.0005919296,0.0051334114,0.016591083,-0.078250796,-0.11286831,-0.042811982,0.06623897,0.0059829606,-0.005424623,0.01957814,-0.06400305,0.03837733,0.0058974717,0.03906649,-0.03753801,-0.073827334,0.04215012,-0.123045295,-0.03239043,0.11127197,0.03474434,0.06714003,-0.037178054,-0.027032107,0.09693787,-0.07975195,-0.07374405,0.0004351543,0.011876381,0.04494172,0.12800173,0.09967487,0.051656134,0.06476639,-0.040666766,0.07043794,0.04527091,0.019988397,-0.06436701,-0.0057258517,0.04331513,0.08931465,-0.01984992,0.036269758,0.058528386,0.021027904,0.02476894,-0.09003031,-0.08947698,-0.025264723,0.06522854,0.03320364,0.041168083,-0.06791218,0.0588297,-0.037940457,-0.07016452,0.048403386,-0.03614671,0.026723787,-0.019246241,-0.007581297,0.07889892,-0.043691233,-0.066240735,-0.058921702,0.04413942,-1.3936521e-33,0.04240969,-0.059168573,-0.007897602,-0.09475631,-0.0351242,0.05609461,0.019682935,-0.0501583,-0.02542572,0.026946226,0.10806304,-0.017622536,-0.0033617544,-0.038059425,0.034469187,0.056747735,-0.067427084,0.025601989,0.0060631516,-0.0064389226,0.08482513,0.013491254,-0.030416818,-0.012113868,-0.0017911112,0.03218226,-0.10576152,0.0653064,0.048856664,0.060229246,-0.07231406,0.081114925,0.0008527481,-0.08586471,0.031352814,0.03184194,-0.09150587,-0.0046098693,0.034616288,0.024571458,-0.026573148,0.019420033,0.04417793,0.09838268,0.00032782066,0.09512486,-0.12927207,-0.00977368,0.005583219,-0.009587825,-0.04688153,-0.0070584565,-0.07563608,0.033529956,0.019806456,-0.01982147,-0.024844924,0.037075933,-0.046700805,0.0097248675,-0.035370726,-0.0406012,0.034008138,0.019388631,0.044190075,0.06015027,-0.05774959,0.055601336,0.027507577,-0.010354936,0.057839163,-0.051322155,0.061293624,-0.047337625,-0.039893243,-0.013014508,-0.007391062,0.061020125,0.010417723,0.0206239,0.021812262,-0.035632472,-0.015312453,-0.04245993,-0.024233839,-0.101592064,0.017471142,0.04311996,-0.035526145,0.017614745,-0.04646181,-0.011512675,-0.029875768,0.00031842157,0.035755977,-4.5359528e-08,-0.04953143,-0.12689508,0.076391175,-6.205565e-05,0.022914385,-0.0019091893,0.03331212,-0.05338373,0.05077157,-0.0146964155,0.029498916,0.057587236,0.040496457,-0.017624788,0.03760484,0.06798386,-0.043770805,0.020663911,0.023603616,0.021049041,-0.01733008,-0.011028092,-0.04302059,0.005353344,0.01958766,-0.072950065,-0.039233714,-0.031212976,0.0052605863,-0.04045159,-0.064471886,0.049507134,0.0025690158,-0.023569033,-0.08809749,0.028252099,-0.0833703,0.031593606,-0.10835119,0.060596872,0.00905129,-0.051221315,-0.0915859,0.0006324896,0.06198257,0.029356018,-0.00018912039,0.03316107,-0.019775376,-0.06531111,0.065024056,-0.031743944,0.05689191,0.028737776,-0.10958147,0.123493604,0.019499501,-0.06869983,-0.020338006,0.0011196393,0.0021502716,0.037438415,0.14476892,-0.048070617 +1.14.11.37,Requires Fe2+ and ascorbate. Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of the aminoglycoside antibiotic kanamycin B to kanamycin A.,384,1.0,-0.0020804144,-0.034182508,-0.10587433,0.06902836,0.041506074,0.036334958,-0.00821238,0.04422092,0.06075822,-0.039694928,0.05195725,-0.0018969288,0.032281462,0.049883068,-0.067604445,-0.05542768,0.007303711,-0.020777388,0.033176105,0.015498847,0.08641321,0.08802756,0.096386984,-0.063851684,-0.027987227,-0.047549523,0.0056903646,-0.042283952,-0.018683843,-0.10795184,0.02685029,-0.0009382769,0.051910553,-0.047328018,0.07985626,0.06968345,-0.02764138,-0.027516868,0.15833044,0.017310727,-0.06725976,-0.08217187,0.026526954,0.030733312,-0.035714407,-0.0002780981,0.07181912,0.0034021218,0.027924921,0.033840414,-0.05925632,-0.004366392,-0.041179925,0.050902322,0.06037176,0.038223907,-0.04409427,-0.054439694,-0.019922728,-0.047911007,0.05830796,0.0066434047,0.026339391,-0.026941108,-0.11273182,-0.012024675,0.040638212,-0.05535559,0.066400334,-0.004334703,-0.006800662,0.001055316,0.005223637,0.07115152,0.034672957,0.021268576,0.0062376466,-0.072457775,0.014046556,-0.06289981,-0.016969072,-0.029149525,0.029927112,0.09751996,0.034408145,0.03631066,0.031330887,-0.02364628,-0.008677708,0.08828371,0.052218854,0.0047716573,-0.023100087,-0.058437586,-0.03087108,-0.07181244,0.03750173,0.0030754425,0.04308959,0.0011106677,-0.070210546,0.02379802,-0.0028047217,-0.03244231,-0.03256039,-0.049608752,-0.048875198,0.011970552,0.026595654,-0.05550443,0.029713472,-0.0051389355,-0.01335139,-0.06629338,0.025406506,0.033234656,0.17290005,-0.07324919,-0.06131896,0.026271818,0.0401194,0.0038473555,-0.023710994,0.06402702,-0.08214068,0.006723828,-0.09742891,3.209401e-33,-0.01086586,0.07881871,0.031788066,0.0048973034,0.0110203205,-0.008114033,-0.053397387,-0.073517084,-0.0024371773,-0.07828424,-0.077114046,-0.08493238,0.010902064,0.05877519,-0.022700956,-0.062593974,-0.033647507,-0.015287189,0.033462666,-0.022442225,0.040867817,0.09708045,0.04186501,-0.04604139,-0.046204764,0.033705235,0.018137673,-0.0023819995,0.101639226,0.00645997,0.047078602,-0.053087577,-0.059837922,-0.04251875,0.07773009,0.006455132,-0.047179956,-0.009867535,0.0054914244,0.049405403,-0.01204962,0.08375698,-0.058340963,-0.0014261247,0.085756235,-0.068261325,-0.012239772,0.10062114,0.03402863,0.049816657,0.06137767,0.005207922,0.09010592,-0.017278027,-0.029783329,0.0057405164,-0.025202759,-0.012068929,0.044514835,0.0911477,0.066703446,0.010161894,0.030554922,0.029505182,0.025256459,-0.011125141,-0.032911547,-0.013030125,-0.014477085,-0.015959663,-0.061150786,-0.016526945,0.022660846,0.043515347,-0.024320656,-0.00061091676,-0.14773534,-0.0043468317,0.052794006,-0.07214974,-0.06392869,-0.034305137,-0.014987724,-0.044336453,-0.06921605,0.05848252,-0.024347462,-0.085995734,0.010478433,0.052982498,-0.04102913,-0.0394517,-0.094845034,-0.028146023,0.06324634,-5.55334e-33,0.039888885,-0.07237821,0.047954362,0.013540578,-0.04097058,0.07980448,0.019849073,-0.1074929,0.039834365,0.005640576,0.0709188,-0.008149812,-0.003057973,-0.09224561,0.045268055,-0.037006155,0.0045975614,0.06961389,-0.0073201703,0.051101398,-0.00704597,0.062283307,-0.01954344,0.057876285,0.03158642,0.082313605,-0.08782285,0.057297457,-0.020852424,0.04134615,0.028536806,-0.018950665,-0.06227735,-0.105514295,-0.07478669,0.020248275,-0.026235892,0.037323523,0.022832435,-0.050164625,0.03378531,0.020781107,-0.0039877067,0.120546505,-0.006819738,0.018194962,-0.049574453,0.07535156,0.07483942,-0.030021474,-0.012959931,-0.07016538,-0.052673362,-0.06701206,0.0054464317,0.036041208,-0.009917983,0.027718252,0.024899643,0.023297017,-0.039102916,-0.05644634,0.041843135,-0.0021311026,0.08195277,-0.026052035,0.014468353,0.047844213,0.07187922,-0.03205496,0.009062489,0.09142806,0.01736528,-0.025252596,0.0054210257,0.01612342,-0.072387226,-0.034143265,-0.006829146,0.012253202,-0.061400816,-0.029608615,-0.011031608,-0.015411773,0.0015010829,-0.07578003,0.06584992,-0.006348959,-0.025416883,-0.0081266565,-0.061765734,-0.0042932983,-0.036984403,-0.008895716,0.044100847,-3.4363488e-08,0.043441333,-0.010978039,0.03762744,-0.059477642,-0.015652478,-0.058705732,-0.025710605,-0.0354064,-0.019071443,-0.07183964,-0.02465495,0.1318358,0.08942328,-0.026534826,-1.3207176e-05,-0.0123293735,-0.017303573,0.05232407,-0.040820193,-0.08249163,-0.08901499,-0.025244283,-0.07841938,0.015084668,0.036617234,-0.013770406,0.012591606,-0.022094749,0.024913743,-0.06648186,0.06971208,-0.011506926,-0.028638827,-0.04036441,-0.03826188,0.007360055,-0.09493902,-0.019277893,0.007913975,0.0059502413,0.013715457,0.009654382,-0.043205444,0.013392255,-0.057341397,0.043953594,-0.059281092,0.042010322,-0.13259088,0.02640522,0.049409542,0.011857322,0.003908863,0.044981778,-0.12349905,0.06952036,0.008504638,-0.054449268,-0.0071291635,-0.08418436,-0.038019788,-0.01515521,0.15689585,-0.038316816 +1.14.13.172,"This enzyme, which was characterized from the bacterium Ralstonia sp. U2, comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.7, ferredoxin---NAD(P)+ reductase), an iron-sulfur oxygenase, and ferredoxin.",384,0.99999994,-0.05129342,-0.033649147,-0.17443505,0.019250587,0.10523504,0.03289414,-0.04648123,0.042008754,0.0061036665,-0.10395689,-0.0004495061,0.001642971,-0.043060947,-0.016936796,-0.10951784,0.020749284,-0.07537723,0.012735627,-0.016186206,-0.037853785,-0.019631494,0.02934851,0.0181681,-0.03955104,0.004963016,0.056098532,0.054157093,-0.019293701,-0.08064046,-0.051427674,0.030686518,-0.027779954,0.11659306,-0.038831253,0.031107305,0.09948786,0.005585469,-0.050586198,-0.016923923,-0.01030817,-0.0056271553,0.023768784,0.034632247,-0.0053270394,0.01487436,-0.014925665,-0.02182162,0.015888458,0.029981934,0.02070443,-0.04645864,-0.050061915,-0.059738863,0.08532519,0.062333785,-0.0069045015,-0.00048247003,-0.10493099,-0.026262864,-0.04947432,0.016315456,-0.039059337,0.027520578,-0.013439316,0.003065103,-0.0057028253,0.015029846,-0.09313052,0.012336404,-0.07424211,-0.04178634,-0.021210592,-0.046501264,0.02108836,-0.027791198,0.0313817,-0.00032115704,0.00075916486,0.06984543,0.011723897,0.030852426,-0.0015781897,0.029786574,0.07725579,0.071171954,-0.028213795,-0.040484145,-0.018969905,-0.006607311,0.06806013,-0.014910569,0.03534715,0.0035387299,-0.039991636,-0.05317213,0.006600986,0.02264557,0.012494464,-0.0051210425,-0.010581106,-0.04677975,0.046481073,0.031482488,-0.0865291,-0.076488,-0.0660821,-0.052083597,0.13723993,0.036309622,-0.017883757,0.021532424,-0.031527713,0.026968235,-0.049788702,0.036669414,0.045321126,-0.0030109792,-0.04212918,-0.072154805,0.025502574,0.058149062,0.062323526,0.05624968,0.06619536,0.038329788,-0.05234592,-0.15494433,-4.93116e-35,0.06907434,0.057879154,-0.050800618,0.02713667,0.010037429,0.01754602,-0.0833579,0.02946311,-0.021157887,0.002855999,-0.07830786,-0.048190486,0.06077456,-0.063094005,0.0034440502,-0.031788833,-0.012458116,-0.035122994,0.07377132,-0.022991749,0.07065834,0.08346167,0.0031463238,-0.0025444184,0.05710974,0.02363433,-0.037801236,0.024881383,0.02491475,0.0014737982,0.06460037,-0.077944696,-0.12383203,0.017402371,0.045908548,-0.022535738,-0.0689927,-0.048879653,-0.07009029,0.059804235,-0.006509902,0.019672267,0.007913582,-0.043568566,0.09669068,-0.07949331,-0.0811625,0.1325235,0.06234417,0.08905821,-0.010199744,-0.01194329,0.120482706,0.018151319,-0.1051929,0.042087108,-0.029843112,0.06116051,0.028947514,0.026949424,0.02943278,0.06969362,-0.016404875,0.045505088,-0.037802726,0.021604303,0.0050583556,-0.014227557,0.03441099,0.13228524,-0.0021499689,-0.0063332412,0.07881955,0.018186755,0.028736725,-0.06301473,-0.054043625,-0.054464962,0.00835076,0.012952329,-0.065215826,-0.035808343,-0.022348657,-0.024989843,-0.06583362,0.029319786,-0.052644007,-0.01906418,-0.022470523,0.019895248,0.037495174,-0.06289775,-0.061909523,0.002020682,0.023318626,-7.903368e-34,0.04384972,-0.0988823,0.039374996,-0.05979603,-0.029610086,0.04876224,-0.0038422104,-0.014488931,-0.049564354,0.0011561024,0.09415558,-0.024357665,-0.005228312,-0.03222783,0.056661293,0.092488505,0.009833727,0.027926555,0.06604905,0.005593034,-0.01852169,0.020107333,0.018681265,-0.0095875,0.017247988,0.013256526,0.0013795176,-0.0026110015,0.11134355,0.03688895,-0.06982762,0.036449265,-0.028656676,-0.071363255,-0.088852204,0.059793733,-0.035996336,-0.024636302,0.034135528,0.019498125,0.036729034,0.010910857,-0.034375273,0.11315759,0.054884918,0.052536212,-0.07541315,0.078026034,0.06093873,-0.045575716,-0.0038470475,-0.022196976,-0.022611193,-0.0027610085,0.029536119,0.029172413,0.05396686,0.04247762,-0.031253982,0.0073411865,-0.013145383,-0.12273384,0.032607004,0.05125596,0.057665754,0.08720962,0.043991603,0.045140825,-0.0045998655,0.0014223928,0.08700483,0.0039885994,0.034016855,0.06681084,0.017814215,-0.054873306,-0.017672602,0.0865051,-0.014699567,0.021868398,0.031593505,-0.034441058,-0.0011422146,-0.023867944,-0.015811684,-0.15711471,0.03792998,0.070748255,-0.00800142,-0.023697808,-0.032734923,0.054229937,-0.016962051,-0.024165818,0.0065683783,-3.441487e-08,0.0130237155,-0.076152466,0.029967973,-0.051658507,0.11393771,0.055756584,-0.0029624752,-0.010689347,-0.032502912,0.0052059726,-0.014110714,0.12490789,-0.044848267,-0.049143806,0.042601176,0.01966074,-0.066281274,0.03604977,-0.004420302,0.006611292,-0.004046364,0.017051738,-0.14065315,0.029921377,-0.019010438,-0.039134484,-0.015248228,-0.013954734,0.0419746,-0.03602084,-0.004477013,0.03687436,0.02787856,-0.05091286,-0.1555324,0.0027486358,-0.01474708,-0.040068936,-0.02614435,0.020181496,-0.028212786,0.015245711,-0.06105237,-0.015931139,-0.0029388333,0.012887467,-0.017371535,-0.004490572,-0.044622444,-0.015253009,0.0420209,-0.019037357,0.042646963,-0.008727283,-0.08689814,0.059261363,0.057464357,-0.10024012,0.035486754,-0.010106507,-0.004561019,0.012930429,0.104519896,-0.012198033 +1.14.13.173,A heme-thiolate protein (cytochrome P-450). The enzyme is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin in the plant Glycyrrhiza uralensis (licorice). The enzyme from the plant Medicago truncatula can also hydroxylate beta-amyrin.,384,1.0,-0.07057346,0.0142914215,-0.092642486,0.027118172,-0.007843338,0.07805265,-0.029022593,0.06148566,0.025369585,-0.041226972,0.050890863,0.02268819,-0.084092036,-0.04252696,-0.066410124,-0.0037225133,-0.075316414,0.026575917,-0.025385054,-0.045082204,0.02430994,0.059884503,-0.019482568,0.026458258,0.036598515,-0.033589937,0.004820913,0.05036904,0.023444196,-0.048238188,-0.015261028,-0.017086614,0.03667195,0.03467067,-0.014906057,0.10966779,-0.050507173,-0.09418201,0.07419337,-0.011310461,0.11927826,-0.016347716,-0.051350202,-0.0062993197,-0.01917178,-0.02598005,-0.029266607,0.014173778,0.0075832056,-0.03248111,-0.030171515,-0.053178698,-0.03901041,0.054401565,-0.020515107,-0.011738649,0.06590872,-0.007607102,0.0062126247,0.048383325,-0.020952433,0.0963111,-0.017086964,-0.00061359914,-0.04726251,-0.08106659,-0.06599725,0.017469125,0.009754491,-0.05815877,-0.01879644,-0.0871173,-0.051835924,-0.019324409,-0.111568935,0.046846107,-0.05166563,0.03178978,-0.016943123,-0.03422545,0.056875285,-0.010308339,0.056330867,0.17045206,-0.0052561564,-0.050352134,0.010036697,0.061452415,-0.00334128,0.024932168,0.08767268,0.0077075004,-0.020443914,-0.026033744,-0.10020726,0.061940968,0.070799455,-0.07938687,-0.033654526,0.0016573778,0.026567882,0.04086785,0.043553177,-0.13556415,-0.054120574,0.059223462,-0.02209451,-0.0050390917,0.12716702,-0.08333673,-0.06971589,0.00043774344,-0.00933349,0.008608913,-0.021933107,0.0642105,-0.017705666,-0.060446616,0.03360073,-0.035980906,-0.004913762,-0.024262795,0.023768505,0.027366769,-0.00090342766,0.023222206,-0.0838372,4.4876807e-33,0.10385313,0.064232945,-0.016021585,-0.035834875,-0.016061507,-0.017080843,-0.07311947,0.031111628,-0.05851778,-0.045552257,-0.09434603,-0.08144694,-0.03228748,-0.016124317,-0.009462515,0.028861534,-0.09420521,0.037727837,0.11029436,0.035558306,-0.023218894,-0.04223397,-0.09112655,-0.06091603,0.03495196,0.10619343,-0.0056708995,0.005269711,0.05396572,0.0041266624,0.025852092,-0.05641631,-0.049746323,-0.007843576,0.07122922,-0.02961515,-0.03225847,-0.013647927,-0.06989589,0.043507982,0.029722465,-0.0022087037,0.015050721,-0.03713384,0.08316976,0.03290178,-0.069564596,0.018332113,0.046677046,0.07808975,0.05927113,-0.057858355,0.11174586,0.045707215,-0.059299786,0.04650923,0.020677539,0.02268814,0.017394409,0.060553037,0.09395423,0.033591777,-0.008785395,-0.005143906,0.04853331,0.08167342,-0.06731181,-0.05247429,-0.010111645,0.06779457,-0.051021628,-0.07901422,0.065080084,-0.029063096,0.00874949,-0.004407924,-0.032360345,0.0023304992,-0.003136028,0.019434294,-0.03825273,-0.04561719,0.0004625837,-0.047668763,-0.023322143,-0.0032581529,0.029137667,-0.008498544,-0.058744002,-0.003924415,0.09269059,-0.029257756,0.0016002586,-0.014913442,-0.014169482,-4.8584144e-33,0.06506765,-0.094813064,0.037778854,-0.08076303,-0.020917455,0.02742193,-0.02591526,-0.07380888,0.017517688,0.06091276,0.07308479,-0.05625733,0.022149833,-0.015982758,-0.015259804,0.005349931,0.011237133,0.06946111,-0.01010216,0.00039489713,-0.0046728556,0.02527018,0.00882024,0.04150041,0.0038702397,0.0022584605,0.04806413,0.018054968,0.024328679,0.01686905,-0.009686472,0.009710568,-0.07142369,-0.045258835,-0.05521225,0.08326042,-0.04396446,-0.0029453954,0.036973182,0.023184841,0.012336308,0.03059768,0.044081498,0.09924597,0.07423673,0.024798209,-0.09565954,-0.017175894,-0.040586483,0.034794822,0.070837826,0.024575299,0.019561417,0.07172958,-0.024709072,0.015950482,-0.027905287,0.025206044,-0.067082845,-0.06617333,-0.014426918,-0.05513976,-0.04478069,0.0298145,-0.0064349887,0.046066646,-0.033522632,0.06695923,0.029351708,0.00011522532,0.050207466,0.026771935,0.075024575,0.09382685,-0.018065326,0.023221422,0.011242709,-0.07708912,-0.00058587134,-0.032834593,0.012663651,0.05237509,-0.05905015,-0.07688771,-0.071396835,-0.07531364,-0.029071955,0.14427814,0.01082683,-0.010758559,-0.010741587,0.08163254,-0.05811059,0.0414934,0.030062443,-3.8019984e-08,-0.018951083,-0.10196558,-0.0018577623,-0.024462711,0.033660408,-0.023597544,0.014065666,0.017325064,0.022213317,-0.0016611776,-0.01505862,0.08237655,-0.054833107,-0.015274868,0.024900343,0.026639747,0.015811387,0.04987069,0.0090800105,0.030057965,-0.018786645,0.033502657,-0.07066146,0.04063429,0.017425777,-0.123506874,-0.012037342,0.015103635,0.009258651,0.011370607,0.08183148,0.07530559,-0.052977253,-0.02321641,0.011782616,0.070399106,-0.055657577,-0.07858669,0.006061279,-0.03858817,-0.0033746527,-0.026673164,-0.057174135,-0.052769523,-0.03293321,-0.011657382,0.0597209,0.017377287,0.030556936,0.008564019,-0.013120231,-0.026698144,0.0018822086,-0.103604235,-0.07096748,-0.015681664,0.044505715,-0.028108152,-0.047740113,-0.047633275,-0.030917628,0.030932693,0.23968571,0.018002298 +1.14.13.174,A heme-thiolate (P-450) monooxygenase isolated from Aspergillus parasiticus. There is no reaction with (1'R)-averantin. Involved in aflatoxin biosynthesis.,384,1.0,-0.052923117,0.05332858,-0.11241102,0.03932679,0.07821697,0.0038578038,-0.096015446,0.08466052,-0.025221677,-0.053008173,-0.007237128,-0.07203647,-0.06616472,0.044986945,-0.09358552,-0.0021641557,-0.019926801,-0.004648897,0.0051044435,-0.06280349,-0.041893136,0.09569171,0.024970096,0.011132347,0.009266672,0.0014179852,0.056183968,0.06912072,-0.04387759,-0.05027797,-0.033712037,-0.04832912,0.036849298,-0.06250804,0.024715511,0.08983467,-0.037300445,0.014586147,0.095025025,-0.026057884,0.028130526,-0.055453774,-0.036485236,-0.04324197,-0.08549367,-0.08031333,-0.06158076,8.731689e-05,0.020798996,-0.0056256955,-0.030924845,0.00094861543,-0.03352093,0.037604723,0.091600865,-0.03833381,0.023686592,-0.051692717,-0.07888613,-0.05241453,-0.019953074,-0.021229751,-0.03693797,0.056107014,-0.09134422,-0.009730009,0.013764553,-0.02805044,-0.019184241,-0.06773078,0.005823212,-0.050367385,-0.0167366,-0.013386899,0.006360115,0.09319721,-0.022482002,-0.014162127,0.06503362,0.008073827,0.07983974,-0.01019293,0.0503446,0.09068721,0.013577306,-0.053699024,-0.043594375,0.061074756,-0.029569672,0.014982273,0.042922284,0.06518684,0.016978545,0.0014977363,-0.00553293,0.02302809,0.058542196,0.03468103,-0.017557716,-0.0081385765,-0.021871343,0.021059172,-0.07093938,0.01672978,-0.015277711,-0.021437539,-0.026831498,0.03196075,0.0864118,-0.043892108,0.019309737,-0.046476163,0.00377476,-0.034968864,0.013552133,0.029308902,0.005378365,-0.037408963,-0.013716653,0.006862563,-0.008948105,0.03009313,0.008247689,0.023985844,0.049189027,-0.020725885,-0.04174175,2.2360645e-33,0.053408436,0.057966217,-0.061461322,-0.036656756,0.054185763,-0.023533694,-0.026973495,0.013210843,-0.009142893,0.047670916,-0.075052395,-0.039088164,-0.05588902,0.0067290408,0.013965192,-0.049823646,-0.017986627,-0.026879458,0.011975715,-0.009121265,0.001348008,-0.0114046745,-0.06561542,0.06270804,0.008507826,0.06799073,0.035111245,-0.01173569,0.034612555,0.0056283385,-0.009480643,-0.020609265,-0.07400477,-0.054553293,0.017666176,0.007819199,-0.03487589,0.0032736952,-0.1028087,0.016181197,0.0033224043,0.046987202,0.014340267,-0.14764197,0.055672627,-0.055661127,-0.101792544,0.09174514,0.09475056,0.08974664,0.091816425,-0.002879429,0.08702908,0.028048977,-0.01626921,-0.025186677,-0.05834589,0.098137945,0.07562957,0.05499719,0.088842325,-0.01818569,-0.015117606,0.05632115,-0.00016242299,0.05547386,-0.02716435,-0.07328827,-0.029951736,0.07738614,0.03591822,0.009015229,-0.0073748813,-0.020597024,3.1139945e-05,-0.007546436,-0.018474791,0.054204486,0.065371595,-0.04573977,0.041337308,0.019703483,0.025190592,-0.018817777,-0.061317556,0.0148299895,0.0112276925,0.052614603,0.013225386,0.042082414,0.04127814,-0.03336375,-0.07907156,0.025920928,0.007888441,-2.9611e-33,0.11617663,-0.07701096,0.033791948,-0.10795299,-0.08499366,0.11455175,-0.0024922348,0.053425424,0.015628163,0.006317419,0.106107816,0.03831377,0.014791975,0.0033821068,0.0132035315,0.0047199954,-0.021307204,0.049005244,0.05902983,0.045795154,-0.021734852,-0.0074273925,-0.0527586,0.029054841,0.06305618,0.041898943,-0.024852099,0.030604595,0.00017925834,0.010929516,-0.061667874,0.084693395,-0.054938655,-0.028660206,-0.06445997,0.10403616,0.015053042,0.0760435,-0.016855912,0.06803567,-0.050263707,0.047330055,0.0069634053,0.1108351,0.04606533,0.036023512,-0.10309043,-0.054862197,0.05619871,-0.07098154,-0.047188688,0.06796745,0.006962922,-0.012565188,-0.022053087,-0.038413357,0.025009738,-0.04638438,0.034085363,-0.13119327,-0.03987509,-0.020094754,-0.028259406,0.036973983,0.051596418,0.08772847,-0.08817204,-0.051263724,0.04867465,-0.02517,0.07380002,-0.019834211,0.012510682,-0.018274754,0.035181556,-0.024169507,0.03579059,0.014881194,0.045087337,0.058306057,0.049544882,0.024013791,0.009582395,-0.015368633,-0.12547566,-0.15423968,0.057040375,0.08027506,-0.07168858,-0.010315474,-0.001135779,0.09290162,-0.022717768,-0.014795509,0.10492063,-3.132566e-08,-0.013342492,-0.046599373,0.026961397,-0.0077667804,0.018984057,0.0035772747,0.02696478,-0.040145565,0.04511257,-0.04721325,-0.050387833,0.040528208,0.005476554,0.017023657,0.02186001,0.009541426,-0.044630542,0.0030614417,0.014483636,-0.003661467,-0.081824474,0.05289717,-0.017353889,-0.060781226,-0.021569435,-0.019621097,-0.0034699338,-0.058224946,0.06390408,0.046575055,-0.0560318,0.08698717,-0.0070877993,-0.09266686,-0.06508868,-0.0019806505,-0.006350009,-0.056367896,-0.034310017,-0.08648695,-0.044018574,-0.074942894,-0.028570475,-0.06703717,-0.001613909,-0.02130601,0.024261089,0.0038616965,-0.010932441,-0.076514,0.082348235,0.0038764593,0.012881626,-0.06608316,-0.0743683,0.0026737393,0.057185195,-0.017459476,-0.049412046,-0.075078286,-0.006397422,-0.016062949,0.18622576,-0.0011964636 +1.14.13.175,A heme-thiolate (P-450) enzyme. Isolated from the mold Aspergillus parasiticus.,384,1.0,-0.030673439,0.061469544,-0.085189275,-0.0050286064,0.051754553,0.0079259,-0.082593724,0.11246463,-0.013393653,-0.044151768,0.009088571,-0.051073577,-0.07256091,0.045743033,-0.08139223,-0.022945473,0.019484023,0.0014756302,0.0100187585,-0.09394295,0.00958405,0.11656361,0.0055870777,0.028789474,0.0028902183,0.0038644369,0.118643954,0.015974864,-0.06161886,-0.08841725,-0.1034204,-0.06039994,0.027132547,-0.04431668,0.03329252,0.10691828,-0.086581536,0.008969727,0.064720646,-0.03969277,0.063390866,-0.08229294,-0.064043485,-0.041411243,-0.090809695,-0.02193476,-0.041441057,0.04757312,0.019375645,0.003382835,-0.033028986,-0.042366706,0.007483032,0.026544258,-0.027909482,-0.023582188,0.066649586,-0.02135364,-0.027772402,-0.0140757775,-0.010017214,0.04204539,-0.03334314,0.007924482,-0.078498125,0.0022359812,0.044894725,-0.0013682296,-0.07056994,-0.060746174,-0.010877441,-0.034879174,0.023963537,0.015117896,0.042804588,0.02547233,-0.010730018,-0.035024453,0.07643496,0.03804552,0.07637102,0.07162164,0.012787271,0.020220298,-0.0067068976,0.015090765,-0.0064906785,0.10573424,-0.00064235996,-0.06274358,0.00017130637,0.07185139,-0.030673852,-0.0013870413,-0.079745375,0.07310082,0.0047908397,0.0980037,0.020926043,-0.020216636,0.033660706,-0.020284241,-0.0006400314,-0.046505406,-0.007991225,0.0033044345,0.010660559,0.029618224,0.13747764,-0.047543537,-0.017869547,-0.008613561,0.023684222,-0.074768096,0.02650584,0.027854288,0.013621451,0.026834657,-0.008254817,-0.023746949,0.018117687,0.0021808385,0.030499376,-0.02501804,-0.0035507227,0.0028943443,-0.059816547,-1.7902384e-33,0.031224197,0.051413488,-0.02384289,-0.0120232245,0.039079633,-0.043124907,-0.015192207,0.06129773,-0.06746562,0.027391352,-0.06876631,-0.10659499,-0.088460445,-0.0037141123,0.0071477974,-0.03715471,0.016168747,0.040366594,-0.018885251,0.009767947,-0.0034704357,0.011285173,-0.08072228,0.089782506,0.0241254,0.066385955,0.034284584,-0.0073231314,0.066744156,-0.022001207,0.029769069,-0.038158976,-0.050189152,-0.054722033,0.054235548,0.027548233,-0.003105743,0.03653982,-0.07107224,-0.03605265,0.01848086,0.029616145,0.046269756,-0.092500366,0.040049482,-0.035717674,-0.10126978,0.053908296,0.04025752,0.008495099,0.0786262,-0.007961423,0.12178897,0.07143743,0.0015645259,-0.010138456,-0.030004594,0.065954864,0.07142265,0.03335245,0.096267894,0.053624325,-0.050876178,0.07431096,-0.03151961,0.01610238,-0.0513193,0.0005950392,0.0017178913,0.04477731,-0.004788838,0.026435819,-0.05136848,-0.052623197,-0.0038470023,-0.061563153,-0.004097956,-0.022137739,0.026374089,-0.05781274,0.022404537,-0.009651983,0.028269902,-0.026538372,-0.089135066,0.0050756154,0.018567953,0.05265615,-0.009608067,0.027490832,0.016307939,-0.081943534,-0.05007345,0.027823923,0.01632403,1.0552532e-33,0.14770085,-0.08990497,0.04943727,-0.050304335,-0.07677341,0.07778835,0.036344822,0.039936993,-0.067354634,-0.028206814,0.09359045,0.01174423,0.023371493,0.0105961235,0.01995851,0.060221706,-0.004031785,0.041387,0.040250305,0.005826982,-0.051723327,0.060300544,-0.01405664,-0.015405528,0.023297695,0.029648574,0.0070883324,0.07481042,0.012576354,0.009682624,-0.041731257,0.042047672,-0.017302888,-0.036090594,-0.107731245,0.0565583,0.03942397,-0.027235728,0.027095454,0.03781527,-0.05592494,0.011278474,0.012651314,0.088977896,-0.00405341,0.12781174,-0.0063424627,-0.029866286,0.00357444,-0.057178527,0.027425786,0.029632179,-0.044453945,-0.020955393,-0.05159671,-0.033341378,-0.023815643,-0.030313773,0.0069064056,-0.11616923,-0.035887856,0.0021729085,-0.015690086,0.059211563,0.03982237,0.07122552,-0.069405876,-0.03677808,0.070086755,-0.04339442,0.014428566,0.040384673,-0.025001228,0.040595204,0.02576986,-0.037456356,0.025784362,0.012145069,0.06347333,0.01164136,0.019967113,-0.031176945,-0.0077036074,-0.0369274,-0.044649076,-0.13477388,0.06425267,0.08947579,-0.056928847,0.027202467,-0.048290458,0.08888395,-0.041780833,0.052155755,0.10006819,-2.3454643e-08,0.02993535,-0.02430458,-0.0094601,-0.089310825,0.005868654,-0.010485131,0.07379329,-0.010334592,0.08382377,0.007691127,-0.10610829,0.02029015,-0.049827494,0.029010402,0.044174045,-0.02141352,-0.02810625,0.041332755,0.016417393,0.0030250994,-0.028394895,0.04848566,-0.04722355,-0.018406413,0.011266197,-0.020118536,0.019748874,-0.046094112,0.046911824,0.028140008,-0.05240765,0.097759314,-0.033849716,-0.07367869,0.031278133,0.04976275,-0.095978394,-0.013305334,-0.030177152,-0.020490667,0.026247298,-0.07993734,-0.0728134,-0.06549217,-0.07614321,-0.065463,0.04478898,0.03088548,-0.011718643,-0.04551718,0.025154637,0.0111873085,0.020358093,-0.06855862,-0.10259086,-0.009069146,0.1072402,-0.037277516,-0.094603375,-0.086941995,0.0080284085,-0.037127577,0.17305233,0.0028581407 +1.14.13.176,"A heme-thiolate protein (P-450). Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.",384,1.0,0.00493614,-0.0040710033,-0.010480526,0.007413329,-0.007009695,0.1182379,-0.019145183,0.09808631,0.05599692,0.01179382,-0.03864596,-0.065976664,-0.05665781,0.05816725,-0.051162302,0.01741512,-0.027713787,0.033531073,-0.010782664,-0.11674683,-0.057660054,0.097636975,0.096247196,-0.027567944,-0.02341012,0.019494714,-0.0030969218,0.0552688,-0.010599946,-0.038553085,-0.016175734,-0.0372537,-0.030819966,0.0046159434,-0.013656988,0.083884284,-0.13818844,0.002870247,0.07716931,-0.019025112,0.04571668,-0.0806152,-0.12505254,0.049095,-0.033452533,0.002164863,-0.023840168,0.020955946,0.033355672,0.041029613,-0.0018482348,0.0016170802,-0.017394315,0.07482008,0.024901846,-0.02591718,0.061299566,0.10787448,0.007901975,0.02006364,0.0063954047,0.056434684,-0.0102788545,-0.023793353,-0.018562192,-0.051021945,-0.03054404,0.011774611,0.0001657079,-0.019924188,0.023875082,-0.047041923,-0.011720252,0.06005655,-0.03667215,0.098610684,-0.05817481,-0.032823313,-0.09969055,-0.04967343,0.09729342,0.02649309,0.027890902,0.10460812,-0.046799865,-0.015308231,-0.03563864,0.05869765,-0.026250694,-0.0481591,0.03751241,0.024811536,-0.03199406,-0.0421026,-0.021375056,0.037705038,-0.0017579716,-0.006092547,-0.005921165,-0.030296486,0.028682685,-0.012435809,-0.064355314,-0.086108245,-0.019219436,-0.011388431,-0.05163922,-0.042769283,0.06559517,-0.0588017,-0.025726613,-0.025966918,0.0900746,-0.009139363,-0.018629214,0.061850484,-0.061659157,-0.010347595,0.0011890085,-0.04602097,-0.03247649,-0.008155401,0.043109663,0.082341745,-0.071198866,-0.049160905,-0.06187629,2.0060779e-33,0.11261781,0.0042198165,-0.008404221,0.07993936,0.009861618,-0.06887432,-0.0712205,0.005419752,-0.018854953,0.0044152588,-0.078072,-0.09508072,0.03264603,-0.03132919,0.026312893,-0.029008277,-0.11180722,0.0064740395,0.019128416,-0.051056113,-0.11073555,0.030417796,-0.03347009,0.005301911,-0.06633701,0.08702656,0.019833958,0.031667203,0.044044822,-0.034696124,-0.047464997,-0.004199158,-0.020523863,-0.05341822,-0.03106683,-0.015921889,0.018224034,0.02192418,-0.08987506,-0.0014471273,0.048758615,0.08450461,-0.008298084,-0.0069223344,0.07355714,0.005730536,-0.09167682,0.07363615,0.030705886,0.08581749,0.066350795,-0.074306324,0.11069585,0.05134326,-0.060065553,-0.00068612734,-0.008282556,0.00939938,0.00934533,0.07275933,0.04651683,-0.025003454,-0.010760035,0.014757565,-0.008188489,0.026949352,-0.024271615,-0.09459432,0.0047256877,0.097240746,-0.035455287,0.026753351,0.053430192,-0.022575784,0.00205072,-0.0007173668,0.010466962,0.04110296,-0.01721122,0.01913006,0.018435942,-0.044034455,-0.024476333,0.03312609,0.023249757,-0.07257703,0.012078005,-0.05390959,0.002030921,0.0015359045,0.03151317,-0.06795777,-0.057028882,0.08396999,-0.0169405,-2.357303e-33,0.0658222,-0.09487476,0.031197783,-0.024550771,-0.038342327,0.063050136,-0.009415065,0.0006196667,-0.019863972,0.04034571,0.15504962,-0.04889554,0.087188646,0.024190545,-0.03631336,-0.08068841,-0.02549698,0.036859047,-0.022705056,0.11249981,-0.044467635,-0.0018518678,-0.023422578,0.042203803,0.047127623,0.10470352,-0.014784442,-0.010116142,-0.05935035,0.027719643,0.066531576,-0.010168651,-0.16350468,-0.031981766,0.01996341,0.017787797,0.0472156,0.010453,0.0007177073,0.0036422818,-0.005074368,0.10072983,0.051935278,0.041908655,0.02084958,0.06574927,-0.05454824,-0.015263821,-0.02575801,-0.082440466,0.033038456,0.0038286177,-0.022336511,0.008497068,-0.02853582,-0.019203857,-0.009716138,0.003124679,0.00459487,-0.051647823,-0.0469024,-0.019830488,0.058870908,0.0075207166,-0.056378648,0.052892316,-0.034049902,0.028587317,0.08025319,-0.022720257,0.026311934,-0.020105384,0.06863178,0.09778878,-0.013527524,-0.063642696,0.01473822,-0.047796927,0.078670286,0.047139313,-0.0089806365,0.07311245,-0.06256158,-0.05586139,0.03374512,0.0019222688,-0.05028175,0.12130283,0.05582042,-0.013239868,0.0051915,0.03526011,-0.02186171,0.087073766,0.0547474,-3.1116475e-08,0.002616149,-0.09873175,0.0051956913,0.02185064,0.0007202747,9.526826e-05,0.022118108,0.02827823,-0.017067526,-0.0525646,0.00561104,0.029526297,-0.09304787,0.017071148,0.01841193,-0.010917387,0.025831884,0.07390959,0.029593816,-0.040951476,-0.06884252,0.04347902,0.023642365,-0.02060816,0.03394916,-0.0592468,0.0020557933,-0.054590214,0.041546613,-0.051233433,0.03930721,0.039612662,-0.016422797,-0.018795878,0.038546413,0.055219896,-0.006571562,0.03264588,-0.029822465,-0.0243393,-0.005344356,-0.052128516,-0.06345315,-0.044744194,-0.038930416,-0.032766525,0.058841005,0.0812585,-0.00032323907,-0.06100007,-0.013624529,0.0044753044,8.784263e-05,-0.08023271,-0.14622638,-0.04786768,-0.002777456,-0.012578093,-0.023025129,-0.13975331,0.004906393,-0.022115992,0.14746358,-0.009209307 +1.14.15.13,A heme-thiolate (P-450) enzyme from the bacterium Bacillus subtilis. The order of events during the overall reaction is unknown. Pulcherrimic acid spontaneously forms an iron chelate with Fe(3+) to form the red pigment pulcherrimin [2].,384,1.0,-0.047971115,-0.03440145,-0.10847641,0.06407242,0.039792176,0.037989672,-0.0021308716,0.03684056,0.005041468,-0.045113444,-0.0009821083,-0.103550754,0.0012239187,-0.0008943643,-0.07343758,-0.0074554016,-0.08020381,-0.0058825277,-0.008102594,-0.05554826,0.0052276286,0.028344063,-0.029545411,-0.0033483573,-0.054188557,-0.015482468,0.1126565,-0.08114992,-0.073762536,-0.07108361,-0.034061316,-0.103704505,0.1540593,-0.028854072,0.038174175,0.08305326,-0.056928266,-0.010637257,0.06634034,0.0021094352,-0.028317945,-0.06452152,-0.054124545,-0.00055522425,-0.028851597,-0.0115354415,0.12278768,0.041569624,-0.026317643,0.016524255,-0.014715672,0.011965682,-0.060280427,0.01854058,-0.042590164,-0.031583644,0.028193183,-0.028942503,0.01871087,-0.023378797,0.005454804,-0.02223239,-0.010624899,-0.01777297,0.009349057,-0.0042137196,0.10729871,-0.101985045,-0.001976942,-0.06382386,0.0012004905,0.015456451,-0.021348532,-0.009579294,0.015499411,0.07440079,0.00728463,-0.021636363,-0.009476635,-0.044103384,0.053013254,0.016963273,-0.027804418,0.15066911,0.047383793,0.025880976,-0.033473857,0.007937472,-0.05707495,0.024963813,0.0012361837,0.042615265,-0.052821487,-0.031056212,-0.121542886,0.04986982,0.0031907933,0.031408265,0.1094434,-0.045075435,-0.04713727,0.06697242,-0.05750046,-0.046300855,-0.0052288785,-0.051517613,-0.03770914,0.092780985,0.058597542,0.03246949,0.050888695,0.014560481,0.029177323,-0.027197462,0.051552188,0.109915964,0.046417262,-0.05982667,-0.052350342,0.0068362616,0.040714983,0.049732614,-0.027575405,0.023290442,-0.071868464,-0.02368869,-0.08216849,3.3686237e-33,0.057588078,0.03546365,0.0319508,0.012048407,-0.0062570293,-0.019196333,-0.14322709,-0.016042283,-0.02657615,0.015443863,-0.042920105,-0.14776322,0.022640567,-0.034480084,-0.019554852,-0.049387284,-0.011131272,0.016398467,0.0043639345,-0.011703572,-0.064854,0.07959022,-0.005925186,0.008900713,0.025532246,0.10006195,0.00011327988,0.0054641394,0.06679272,-0.04865285,0.056862727,-0.07120392,-0.054397017,-0.054446425,0.04944074,-0.022329848,-0.009511321,0.054999057,-0.08241733,0.0340355,-0.0041088318,0.08525504,-0.0035004232,-0.042232573,0.095894076,-0.062123023,-0.08835453,0.106686935,0.023465304,0.07429257,0.00068489887,0.018601092,0.161306,0.022354435,-0.009288678,0.033243302,0.0480133,0.04358733,0.044497438,0.057862256,0.15147355,0.07971179,-0.02745475,0.06948051,-0.041117862,0.03548658,-0.01310394,0.02194474,0.06978461,0.061263695,-0.06802199,0.09944439,0.035695348,-0.061846532,-0.0007100868,-0.038784016,-0.08597628,-0.023057085,0.033302426,-0.019153595,-0.0058543845,-0.013793545,0.015254635,-0.029173627,-0.080466494,0.024294,-0.015174984,0.04773557,-0.032874804,-0.0140162185,0.032549996,-0.06977256,-0.025695669,-0.035812486,0.018193515,-2.9806812e-33,0.09277814,-0.10671875,0.06487384,-0.043769594,-0.073595196,0.02868551,-0.05498662,0.025202364,-0.083590984,0.04295452,0.103231095,0.02081621,0.02887456,-0.0017995915,0.034471553,0.069678575,-0.013334477,0.08440478,0.018315125,0.014206453,-0.058910623,0.036096014,-0.014761851,-0.039943714,0.03826774,0.05306495,0.01456303,0.06316369,0.05072958,0.016679687,-0.010779726,-0.014172224,-0.0305558,-0.05882837,-0.07953333,0.011142123,0.025636405,0.00026354022,0.075265706,0.028936816,-0.020694526,-0.026954342,0.0458106,0.08639492,0.03251145,0.07414889,-0.0519773,0.019977532,0.014153834,-0.012495815,-0.014601665,-0.020050127,-0.04757118,-0.035213917,0.040558394,0.016666343,-0.011134243,0.031703737,-0.009056771,-0.057326827,-0.065855704,-0.04385225,0.056712512,0.014410823,0.014121199,0.0746919,-0.035777785,0.06692926,0.057902206,-0.035552893,0.0745493,0.024421351,-0.0030574838,0.014158122,0.028509948,-0.036882654,-0.004685461,0.034904044,0.013634457,0.07780214,-0.027460378,-0.0042630234,-0.03755414,-0.0100076385,0.036464017,-0.094075285,-0.0064883144,0.03785098,0.0034027754,-0.06980155,-0.049593743,0.02910258,0.05890646,-0.00051819964,0.009453982,-3.627625e-08,0.02509348,-0.089619406,-0.0037070678,-0.024525926,0.075974785,-0.0068073114,-0.021766588,-0.08607117,-0.008528791,-0.04272826,-0.044929538,0.04092108,-0.0012984256,0.000375468,0.056574948,0.00059073744,0.012193213,-0.022990093,-0.0116601875,-0.032224014,-0.11761746,0.0468342,-0.068958916,0.027845746,0.0141269965,-0.029302238,-0.026812378,-0.083824106,0.00020573438,0.00873329,0.008113292,0.08449934,-0.037737887,-0.051235396,-0.0045416886,-0.0052729715,-0.091966,0.002567947,0.0015323939,0.0313477,0.012840246,-0.0089856,-0.1125506,-0.004038808,-0.017313624,0.023810513,-0.022455223,0.02358566,-0.044606563,-0.013816288,0.010041158,-0.015133576,0.052345283,-0.016440302,-0.10262366,0.075521745,0.06050874,-0.049004752,0.014194239,-0.0005737092,0.020928165,-0.027243413,0.10263065,-0.015475748 +1.14.19.8,A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae.,384,0.99999994,-0.054203473,0.0011682438,-0.10804101,-0.009805684,0.037064455,0.062018726,0.0080114035,0.113965206,0.060788423,-0.03380414,0.0053472165,-0.062369615,-0.038780294,0.067208655,-0.032653008,-0.043285877,-0.00418555,-0.00038302952,0.04145025,-0.0823464,0.006282742,0.13333362,0.0048684888,-0.015460868,0.012702114,0.028167214,0.038009487,0.02187854,-0.067003444,-0.06935044,0.007157426,-0.07223469,0.0802941,-0.030499995,0.09324424,0.12857121,-0.0737399,-0.07833348,0.096262485,-0.057719238,0.058209226,-0.016862102,-0.024319027,0.044834357,-0.05006264,0.07062379,0.03490848,0.105303295,0.037828207,-0.018553652,-0.029494744,-0.07422017,-0.08499565,0.09057941,-0.0020957764,0.031241393,0.0673903,0.031680483,-0.005440304,-0.046299513,0.040306605,-0.008768879,0.042978115,-0.020152343,-0.094271906,-0.012892964,0.013506538,-0.009838399,0.01033336,-0.03171094,-0.012576973,0.018240977,-0.0002916211,0.0898596,-0.03889632,0.10164198,-0.040280808,-0.015017015,-0.013403741,0.019480728,0.07865716,0.024408873,0.009032835,0.111440204,0.018777825,-0.04489006,0.0019519241,0.06536743,-0.006700488,-0.05822135,0.018744878,0.04205047,-0.02684558,-0.048411615,-0.0938797,0.024198001,-0.053847898,0.009915502,0.007197967,-0.0019716856,-0.01841473,0.010986505,0.06263422,-0.043642323,-0.045454033,-0.020451384,-0.023596758,0.033859555,0.07175842,-0.07325542,-0.008053756,-0.016029675,0.0117606595,-0.08107625,0.0335933,0.04286754,0.063072994,-0.031593103,-0.0299736,-0.08262217,-0.056324255,0.00019576309,0.088516936,-0.0019467865,-0.056506045,-0.006672345,-0.11324645,2.247517e-33,0.016162477,-0.004930116,0.077472925,-0.0112310415,0.033249673,-0.02732555,-0.07240915,0.017588034,0.003786936,0.0016981029,-0.05724118,-0.11704842,0.037197586,-0.056424424,0.0438648,-0.026887102,-0.052488253,0.06692569,0.03258712,-0.0057541872,-0.05002352,0.066176675,0.0012225326,0.025134286,0.038797494,0.06649015,-0.002731837,-0.04782079,0.10721821,-0.033673953,0.0033269152,-0.05821166,-0.06444926,-0.07673714,0.04375204,-0.013003653,-0.057842474,-0.016924283,0.0066856043,-0.0253677,0.023422394,0.034716908,0.06547335,-0.03382982,0.036952123,-0.043055274,-0.0826748,0.021246796,0.035816845,0.026913688,0.043139063,-0.061111547,0.12112647,0.021307616,-0.067850254,-0.01344182,0.014952475,0.11988805,0.05774225,0.033805627,0.117901094,0.043830823,-0.041925725,0.019917833,0.009311804,0.056717355,-0.063503824,0.022435132,0.013673196,0.058975887,-0.018748846,0.015529207,0.032029323,-0.086630106,-0.01490365,-0.036221012,-0.04951187,0.003965508,0.028947674,-0.0017738234,-0.045186196,-0.025388544,-0.045608725,-0.027125603,-0.07046623,0.07297406,0.041159328,0.02836113,0.03377767,0.048289157,0.027359761,-0.049030617,-0.08379304,0.068662785,-0.029735526,-1.5236845e-33,0.12674949,-0.0874505,0.043104835,-0.03560989,-0.045050833,0.08554749,-0.02479674,0.03014442,-0.08691419,-0.036278784,0.102044486,0.012117879,-0.0135555845,-0.032163672,0.029364567,0.0070502227,-0.036852386,0.019169023,-0.008148157,0.06530214,0.016673833,0.0076103676,0.026817283,-0.02880838,0.027326677,0.037793346,0.015479853,0.018308103,0.030835973,0.009875011,0.0011779477,0.02712019,-0.06715541,-0.10356012,-0.11177341,-0.004686388,0.016066859,-0.042233292,0.06201018,-0.017652048,0.02569616,0.081150316,0.01791774,0.10745076,0.039209522,0.13098593,-0.027210701,0.0017663155,-0.06033065,0.015777078,-0.019306906,-0.03362567,-0.06816324,-0.012499798,-0.06606214,-0.032476734,-0.022552462,0.062019568,-0.056450095,-0.064269595,-0.018292867,-0.055560008,-0.008286816,0.05440103,0.05590723,0.073033236,-0.06887125,0.04073929,0.06218939,-0.024101112,-0.004479034,-0.01426652,-0.024605516,0.045693446,0.043494634,0.010593639,0.007353342,0.007018476,0.06668279,0.028236773,-0.00976759,-0.030993572,-0.044436675,-0.040833518,0.02935899,-0.04778286,-0.0013496238,0.05353908,0.014541349,0.055290364,-0.06629625,0.046635106,9.399274e-05,0.07171046,0.044481706,-2.9111783e-08,0.003373411,-0.058108114,0.013927142,-0.018855626,0.010856596,-0.04488507,0.011862699,0.023060761,0.050075542,-0.0054651294,-0.031097189,-0.061121464,-0.06110001,-0.022797825,-0.023879698,0.031164384,-0.070198484,-0.00852121,0.028721996,-0.012290123,-0.063105695,0.02292803,0.00081662525,0.044303216,0.037963632,-0.05810028,-0.010152932,-0.06290158,0.0044708676,-0.013565945,0.010026404,0.053273406,-0.047246423,-0.023421327,0.058071833,0.027700802,-0.11108233,-0.0180256,-0.013938346,0.031471968,0.0071811876,-0.040922146,-0.083467655,-0.04454533,-0.05427714,0.04695781,0.019454814,0.05465912,-0.07687959,-0.06046245,0.021410817,0.0051193703,0.014821073,-0.02538474,-0.14936239,0.023004986,0.05618888,-0.03497926,-0.06430778,-0.054948796,-0.006712553,-0.061517816,0.1631178,0.012389282 +1.14.21.9,A heme-thiolate (P-450) enzyme from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product.,384,1.0,-0.074682236,0.031450775,-0.034330282,0.02406519,0.06396377,0.0040133162,0.007601233,0.112365656,-0.028811978,0.027397253,-0.06931349,-0.015323065,0.031074068,0.021823838,-0.03064877,0.055490542,-0.048262462,0.0030606631,-0.026983192,-0.07495283,0.008520134,0.12392497,0.036668953,0.003456028,-0.0016156158,0.009245555,0.09394711,0.040651914,-0.048440117,-0.06853639,-0.024552384,-0.08349029,0.058256663,-0.06808317,0.040391576,0.081839174,-0.051491678,-0.07769816,0.05189717,-0.02066797,0.053116705,-0.069805555,-0.07800748,0.03317629,-0.0015716113,0.015655966,0.0023031395,0.059650674,-0.011124891,0.009318733,-0.05480032,-0.023444938,-0.1132707,0.02294188,-0.0048289797,-0.02942996,0.024406148,-0.012023317,0.040974747,-0.032643046,0.026559042,0.025109962,0.017854005,0.04499324,-0.008430393,-0.028618533,-0.007677402,-0.027509987,-0.06227914,-0.053290173,-0.05234784,-0.047528494,-0.074730694,0.07041862,-0.05088067,-0.015257636,-0.009101413,-0.05136302,0.015899928,0.09299573,-0.01359145,-0.016874177,-0.042134874,0.042802498,0.028436473,0.0047487123,0.03762786,0.02085142,0.009379974,-0.031063601,-0.035622668,-0.0016477662,-0.004029618,-0.03269884,-0.09106186,-0.003312876,0.05536378,0.049030025,0.016261468,0.010001419,0.007647914,0.04119684,-0.0359076,-0.07376891,-0.06140024,-0.010746828,-0.030587276,0.041297257,0.10983016,-0.029875303,-0.021756982,-0.031185923,0.024404895,-0.023000346,-0.0063206893,0.103210285,0.044860166,-0.01137268,-0.07396632,-0.013706498,0.017620556,-0.066470385,0.023277525,-0.00030598982,-0.11546975,-0.012679448,-0.05249355,1.747124e-33,0.033987124,-0.040981594,0.032601297,0.0073966794,0.016222095,-0.027801538,-0.092138305,0.015392184,-0.023572687,0.011829153,-0.09411504,-0.09064702,0.020615643,-0.002079523,-0.037878178,-0.004588441,-0.053369127,0.043462165,0.03896383,0.06167307,-0.018291352,-0.023634644,0.00762378,0.09741819,0.0360272,0.07117408,0.024894329,-0.02761972,0.053919792,-0.0046748305,0.0020822107,-0.030793073,-0.05618899,-0.116042554,-0.046737738,-0.033499762,-0.06979607,-0.010359006,0.012118135,0.02041689,-0.014702536,0.025457336,0.02481522,-0.037980925,0.059659272,-0.0041885115,-0.033244498,0.047728267,0.00082948804,0.029938234,0.040712554,-0.047872156,0.10080601,0.015664851,0.00982849,-0.01185442,-0.007964748,0.10074106,0.06118101,0.03596257,0.13702531,0.08028511,-0.023755202,0.0805338,-0.05211962,0.035312533,-0.016801076,0.00087378745,0.073323585,0.03333771,-0.0012967887,0.062320825,0.010897742,-0.07468603,0.040231332,-0.05300671,-0.029957687,0.010076025,0.06083706,-0.07993015,0.052921012,-0.015538439,-0.018036276,-0.051725358,0.027311828,-0.039303634,-0.07056253,0.020848317,-0.06413431,-0.007821292,0.05527064,-0.0706261,-0.028923623,-0.019272948,-0.043611687,-1.5868645e-33,0.10561201,-0.12818219,0.04190108,-0.07163081,0.018848564,-0.022245301,-0.011744246,-0.035789233,-0.040289506,-0.011431351,0.061557576,-0.028048325,0.044240106,-0.002622129,0.023106463,-0.014910248,0.006879586,0.00058091467,-0.050311014,0.031272527,0.032189105,0.022429053,0.012011127,-0.08997722,-0.004480508,0.078800686,-0.079008564,-0.009242983,0.12974645,0.049310125,-0.07336971,0.040315673,-0.011930239,-0.073424034,-0.1024914,0.03224773,0.022397978,-0.01615695,0.061045583,-0.012108043,0.0068772356,0.061108146,0.021405239,0.045765113,0.005654272,0.064984106,-0.084648676,-0.0625575,0.002497975,-0.047538288,0.046296313,0.03138453,-0.06191537,-0.025768902,-0.013659399,0.004025464,-0.02249111,-0.03338187,0.0063931826,-0.116728045,-0.05161686,-0.022248898,0.056501012,0.04077613,-0.0007761963,0.15041663,-0.0121001955,0.09500946,0.05438214,-0.031255763,0.052107457,-0.010647359,0.012829357,0.018990526,0.055616006,-0.0026927034,0.0040106094,0.038249597,0.059895188,0.05236597,-0.06164692,0.00016324224,-0.04577818,-0.08137208,-0.003298014,-0.11280902,-0.038316317,0.0952086,-0.002378201,0.053586077,-0.044867624,0.06744653,-0.014006771,0.087148845,0.09146218,-2.8054393e-08,-0.019046357,-0.077516235,0.07666562,0.031886138,0.057321623,0.029547973,0.04605734,0.027746066,0.108322605,-0.03520073,0.03905902,0.06552461,0.019009253,-0.042172875,0.0666641,0.01648816,-0.023699688,-0.029050292,-0.002136724,-0.035234805,-0.04166846,0.047828626,0.008662151,0.063219,0.023660896,-0.06885386,-0.030586077,-0.043212447,0.00039520598,-0.021084044,-0.035463896,0.10953053,-0.04620408,-0.056592654,-0.052653782,-0.033898678,-0.0054360945,0.003506408,-0.0045833252,-0.017953176,-0.0075992667,-0.049842305,-0.089891545,0.0058643823,0.0192629,0.03242785,0.022068836,0.010182365,-0.048960574,-0.048713267,0.032497652,-0.005884494,-0.01015529,-0.020460803,-0.10861909,0.07302042,0.044051267,0.006167112,-0.07319584,-0.07965012,0.03700596,0.0025142215,0.22916241,0.0070513682 +1.18.1.7,"The enzyme from the aerobic bacterium Ralstonia sp. U2 donates electrons to both EC 1.14.12.12, naphthalene 1,2-dioxygenase and EC 1.14.13.172, salicylate 5-hydroxylase [1]. The enzyme from Pseudomonas NCIB 9816 is specific for the ferredoxin associated with naphthalene dioxygenase; it contains FAD and a [2Fe-2S] cluster.",384,1.0,-0.073545076,0.023760809,-0.085755646,0.02217667,0.07805264,0.038347524,-0.063248165,-0.011017223,-0.01034314,-0.08043203,-0.001558831,-0.103106834,-0.028430132,0.04407471,-0.05428063,0.01010396,-0.07651591,-0.022798002,-0.00015915885,0.022139654,0.012889781,0.09957014,-0.0012660079,-0.012384608,0.047510736,0.04356367,0.047887757,-0.016853226,-0.05556181,-0.050954465,0.0125040645,-0.009759964,0.07380064,-0.017978976,0.05880659,0.08069144,0.0059599024,0.0018265102,0.07136324,0.029540457,0.009474655,0.018921498,0.02790107,-0.070076324,-0.058209967,-0.004031728,0.038184613,-0.01060546,0.06664949,-0.0021659879,-0.05855754,-0.0564598,0.001528218,0.067319095,0.055766117,0.016206214,0.038132276,-0.06800517,-0.070325784,-0.023816051,0.014053545,-0.04234413,0.024096498,0.050201688,-0.016901623,-0.042611923,0.009777506,-0.06735914,0.025739377,-0.123996735,-0.050013304,-0.04316273,0.064868644,-0.020776281,-0.015430746,0.013587869,0.027148813,-0.061777126,0.065538734,-0.0604489,-0.018088575,-0.06159458,0.05027505,0.07887326,0.03476202,-0.026118586,-0.012590675,-0.035619028,-0.028773272,0.010826193,0.0038802384,0.039596293,-0.020109892,-0.048759345,-0.02829414,0.016964743,0.019671699,0.04314328,0.00041104652,-0.029077098,-0.016299712,0.096397765,-0.026351146,-0.09031953,-0.028848574,-0.047924288,-0.007430904,0.070736684,0.050996084,-0.018117903,0.05155357,0.0016841944,0.07210058,-0.018705398,0.0353304,0.04860489,-0.0021908581,-0.075603925,-0.06438725,-0.010409027,0.00053746044,-0.08638013,0.049725775,0.058806196,-0.0066494695,0.009000325,-0.14554664,3.3684415e-33,0.07199954,0.051658377,-0.07816327,-0.04933134,-0.0034242189,-0.016601324,-0.08441101,0.022183254,-0.013619599,-0.06523365,-0.050658423,-0.008709212,0.077874206,-0.04400262,-0.031110855,-0.05820928,-0.07669138,-0.012336812,0.05660053,-0.010954705,0.04630708,0.061774816,-0.022146648,0.006984085,0.048635658,0.0497792,0.017446088,0.03399173,-0.004884062,0.003319984,0.113476254,-0.022458468,-0.104412235,-0.015627291,0.04559319,-0.014856177,-0.02659883,0.0047613895,-0.046457842,0.042437494,-0.01529084,0.07720224,-0.0039566644,-0.09228933,0.08361655,-0.08185968,-0.05420295,0.15937492,0.08754303,0.09916933,0.0113190375,-0.036187243,0.09654983,-0.035499718,-0.060053036,-0.0057644327,0.0068708453,0.03811099,0.088844545,0.06783091,0.035014227,0.034678765,-0.037818216,0.013436129,0.0026233534,0.03072052,-0.0011979789,0.026282849,0.021365173,0.1267215,-0.02555819,0.0271716,0.08178958,0.005018921,0.036916547,-0.060076278,-0.04770832,-0.022167856,0.048127845,0.017799586,0.057730023,-0.028369358,0.00594903,-0.059953514,-0.045757074,-0.036206122,-0.026477147,0.006944036,-0.035120077,0.044958945,0.051536247,-0.084304,-0.0765264,-0.002021138,-0.004032787,-3.3120314e-33,0.087310776,-0.050217807,0.0049523464,-0.07905491,-0.0063943416,0.08477029,0.035932787,0.017714325,-0.014042274,-0.0065008835,0.12442551,0.03753525,0.058507983,-0.02768607,0.057406794,0.03202054,-0.040626846,-0.006252176,0.010031983,0.025733138,0.035266712,0.019682078,-0.04558314,0.020640535,0.091192506,0.030953009,-0.046989143,0.057721637,0.08909144,-0.010988384,-0.026889494,0.048343584,-0.06955388,0.0020910462,-0.018100772,0.03909759,-0.06686476,0.03793806,0.041846607,-0.028839787,0.024767218,0.010312132,-0.050966885,0.110439084,0.041790508,0.018207492,-0.11440866,-0.026861217,0.017885335,-0.059192244,-0.06553374,-0.004327378,-0.0040481584,-0.029160818,0.0072529665,0.07703175,0.024191692,0.030803358,0.003642285,-0.06305772,-0.029022438,-0.09095591,0.05225963,0.056619618,-0.037702326,0.023372557,-0.014093053,0.0592147,-0.006638481,0.030895695,0.01388684,0.009046462,0.041213643,0.0063421056,-0.11314234,-0.011757082,0.006161592,0.04394834,0.0072582136,0.03395842,0.076339245,0.04302709,0.004675624,-0.059692364,-0.004769545,-0.058896117,0.05788971,0.054238833,-0.019446647,-0.0155713465,-0.024678828,0.030659476,-0.005307715,-0.06283045,0.044218097,-4.122462e-08,-0.0106383795,-0.083331674,0.12003978,0.0026928587,0.05592662,0.039817724,-0.0036400193,-0.018052366,-0.031218072,-0.016706085,0.05435915,0.10397209,-0.024703056,-0.044164162,0.030155148,0.002282603,-0.10172491,-0.022700408,-0.009888457,0.019379057,-0.047731943,-0.029870527,-0.12821531,0.063759685,-0.029076412,-0.036515743,-0.0032537053,-0.033438202,0.0037967486,-0.0757099,-0.08864661,0.002505031,0.011162493,-0.06692245,-0.100537695,-0.011070203,-0.019261071,-0.02697038,-0.07616211,-0.0011153398,0.039843045,-0.055588476,-0.06620601,-0.015250732,0.043736815,0.024139244,-0.0026103354,-0.055432737,-0.0025562467,-0.044121347,0.08544531,-0.051862102,0.021247076,-0.0064758305,-0.12407275,0.105384074,-0.071041904,-0.062236693,0.004636133,0.03805993,0.0010562168,0.051180974,0.13219927,-0.038150407 +1.21.3.9,"This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. The enzyme also possesses catalase activity, suggesting that the secondary product may be hydrogen peroxide rather than water. The nature of the secondary product has not been confirmed as of 2013.",384,0.99999994,-0.040578693,-0.019713113,-0.12640542,-0.024141088,0.024613375,0.042193256,-0.03248295,0.06742719,0.0840345,0.022192843,-0.030603398,-0.036076017,0.024258807,-0.020261131,-0.084364094,0.1047126,-0.038730554,0.04450364,-0.04708741,0.0032357653,0.032243893,0.0024906946,0.029116768,0.008382712,0.077850744,0.063762255,0.047184248,0.08062261,-0.11270253,-0.068071835,0.03534302,-0.058570266,0.036283538,-0.03401656,0.089442916,0.02211011,-0.021830177,-0.019275483,0.10101391,-0.0018024162,-0.028139673,-0.039270826,-0.040868472,0.019105442,-0.09033739,-0.007973699,0.034496877,0.03289483,0.048701648,-0.04388136,-0.051232968,-0.070541285,-0.053240053,0.022672584,0.028573632,-0.039263725,-0.038590357,-0.022908652,0.008963658,-0.0030646997,0.05983053,-0.018601583,-0.024642516,0.014334328,-0.05910471,-0.107218,-0.014715188,-0.060915183,0.017010663,-0.04737288,-0.055084676,-0.05326718,0.03399598,0.049633674,-0.0025410685,0.0045334883,0.021565922,-0.04286636,-0.014026809,-0.026255863,0.018234953,0.024516698,0.056683667,0.15571289,-0.0070086066,0.08169965,0.053401683,-0.00030318764,0.031889386,-0.012364467,-0.01747639,0.02884196,-0.0023376495,-0.07172362,-0.075871535,0.004331369,-0.016786523,0.08452078,0.021350512,-0.002531704,0.017691143,-0.0021922076,-0.01675995,-0.100208394,-0.03647569,-0.014941634,0.0018985232,0.09884903,0.08799558,-0.070473626,-0.0037673481,-0.03150519,-0.01891102,0.0058870856,-0.04327567,0.096433915,0.10862726,-0.06038345,-0.123286836,0.025454227,0.043057766,0.009092799,0.07535862,-0.025838297,-0.043590423,0.03392663,-0.074699074,4.8108855e-33,0.04975703,0.09547656,-0.022519147,0.0009746987,-0.021375623,-0.014648742,-0.1369259,0.011256135,-0.015032859,-0.024524564,-0.11900355,-0.05476882,0.0046757385,-0.045139853,-0.036117677,0.0065019247,-0.061495908,-0.017845524,0.029018626,0.053697184,0.026390838,0.029573614,-0.047653057,-0.012927031,0.0025882262,0.030683221,0.04060579,-0.015513888,0.0692476,0.00043339803,-0.0046637948,-0.029615441,-0.102267414,-0.049640667,0.022561273,-0.017252004,-0.042670246,0.0253091,0.009232117,0.07001686,-0.0035711725,0.032193888,0.015432783,-0.0036109476,0.058930095,-0.06835398,-0.029546378,0.13090856,0.107965976,0.046308115,0.0047333785,-0.027549697,0.16108847,0.03824581,-0.083631195,0.021795869,-0.018618919,0.019896125,0.07525595,0.041360155,-0.0047099823,0.048642922,-0.0034656979,-0.002930733,0.05839167,-0.045123607,-0.004721705,-0.05091204,0.031248987,0.084423654,-0.044414766,0.0091037,0.10392547,0.04492486,0.026182009,-0.05245419,0.01092899,0.010731081,0.092390455,0.022532897,0.045740634,-0.05476038,0.019491749,-0.07853843,-0.037295736,-0.015451834,-0.080145165,-0.037068777,-0.0963957,0.079924546,0.026684657,-0.0906412,-0.09600816,-0.03017218,0.009041488,-5.467822e-33,0.09977685,-0.08564057,0.020498237,-0.057676546,0.025393497,0.037197977,-0.022765154,-0.0015049725,-0.028381266,0.013111321,0.114472836,-0.047237836,0.03554075,0.008681701,0.02227664,-0.04786709,-0.038909804,0.08602457,0.0031074698,-0.029565096,-0.027246933,0.086889386,-0.038275406,0.0033003748,0.06054174,0.04216369,0.009772655,0.038717214,0.027392684,0.05984884,0.044318598,-0.004683922,-0.077415496,-0.048658416,0.0042523793,0.06479413,-0.083272316,0.010247582,0.06251483,0.0054371157,-0.019367805,-0.015205622,0.012516929,0.023171628,0.065362185,0.02580987,-0.07190965,0.06620056,0.024614813,-0.059521932,0.01914789,0.007513995,-0.084988795,-0.017224666,0.046126965,0.034695182,0.04522856,-0.020326331,-0.016037593,-0.0079400465,-0.07734092,-0.025869986,0.08626608,0.0059044734,-0.0323725,0.121511236,-0.008705555,0.05247596,0.07079474,0.0061968924,0.023682388,-0.014615433,-0.006909138,-0.024373004,-0.018108401,0.014016211,-0.02385627,-0.024117745,-0.011379674,0.014282372,-0.027307095,0.007150325,0.03704099,-0.041597914,0.014153416,-0.056078188,0.010740385,0.052244574,-0.024124881,-0.016525878,0.05660928,0.008908008,-0.011287786,0.08615759,0.020873992,-4.5109413e-08,0.05156272,-0.07148921,0.049415782,-0.04444708,0.003886443,0.014879435,-0.01527058,-0.03297785,0.055472095,-0.03774178,-0.005214466,0.08990789,-0.03780323,-0.011222887,0.008137647,0.0068496247,-0.006270862,0.0347657,-0.011635819,-0.004243762,-0.0438482,-0.039097738,-0.06594099,0.0295591,0.0063874996,-0.046027236,-0.007550167,-0.00054057187,0.027993558,-0.036410626,0.050392833,0.0646474,-0.062903054,-0.028978962,-0.06138112,-0.036399927,-0.06407713,0.027015487,-0.05978033,-0.057116102,0.07983195,-0.069799,-0.10689618,0.036427476,-0.03688854,-0.008759192,-0.0161074,-0.023472914,-0.054872327,-0.053913474,0.041409794,0.025605254,0.026809724,-0.026560912,-0.15032089,0.064696506,0.015781272,-0.050236627,-0.02216823,-0.08496484,-0.04300421,-0.030491807,0.14012538,0.0015647601 +2.1.1.269,"The enzyme from the marine bacteria Pelagibacter ubique and Ruegeria pomeroyi are specific towards S,S-dimethyl-beta-propiothetin. They do not demethylate glycine-betaine [1,2].",384,0.99999994,-0.08927512,-0.0249737,-0.11808277,-0.07694824,0.024870617,0.06958916,-0.052190077,0.00035856347,0.014763251,-0.029509958,0.029438501,-0.021269254,-0.025414703,0.078212306,-0.008982789,0.043297626,-0.03142753,-0.0034345884,0.03410936,0.05095965,-0.014554673,0.050243225,-0.0522972,0.01640665,-0.023430329,0.020935493,0.019476531,0.03252264,-0.013091884,-0.025088875,-0.0056615802,-0.037907224,0.066245064,-0.06766914,0.09562519,0.015476972,-0.012501026,-0.05718186,0.023622232,0.077276215,0.05575153,-0.0014755722,0.016422406,0.05637869,-0.014833922,-0.033489693,0.065867424,0.024488645,0.012191555,-0.022839803,-0.06475225,-0.078245215,-0.0133349905,0.006128863,0.07246348,-0.02481993,-0.030467996,-0.026727384,-0.0200604,-0.071915165,0.03390155,0.03213553,0.03892671,-0.053423595,-0.09244692,-0.02129646,0.026300067,-0.060558096,0.05232005,-0.0051544625,-0.028394954,-0.033128276,0.013810514,0.080780625,-0.058128104,-0.021827783,-0.032724895,-0.012483283,0.013791573,-0.03825628,-0.095002376,-0.097547345,-0.017977677,0.026966307,-0.013167358,0.00029849034,0.028838567,0.04349961,0.06947661,0.017957084,0.08906465,-0.024015298,-0.04012271,-0.09739985,-0.026501296,-0.027726198,-0.07512358,-0.03772655,0.018558176,-0.02596628,-0.053861726,0.06593253,-0.028114641,-0.063083045,-0.01730597,0.008688441,0.06284897,0.08831834,0.009929777,-0.0047297473,-0.018801292,0.05339569,0.06765768,0.09230787,-0.031910695,-0.011913088,0.006286426,-0.055310693,0.00057538634,-0.0049629766,-0.015586767,-0.01498268,0.018219918,0.078103594,-0.051281933,0.029317385,-0.111973315,2.1534357e-33,0.122464,0.01133299,0.055496983,-0.031414967,0.04935561,0.009689918,-0.12848829,-0.033529516,0.02825874,-0.045127213,-0.10919164,-0.024253536,-0.014202206,0.122262694,0.015119336,0.055538837,0.012923464,0.014035837,0.066078044,-0.06472598,0.071903564,0.06610961,-0.034533247,-0.09318729,0.097198784,0.02691576,0.08002803,0.020053554,0.042933397,0.0124902185,0.032080323,-0.1511979,-0.04947484,-0.0067383596,0.07566059,0.010261124,-0.04025168,-0.003773625,-0.0079279365,0.04145988,0.025823139,0.012543172,-0.017562203,0.027967678,0.0684042,-0.009606629,0.010766918,0.06588001,0.03362916,-0.01571551,0.06338074,-0.042824127,-0.004516817,-0.026892837,-0.09286232,0.07805765,0.012686144,0.06712224,0.013616491,0.017922314,-0.032876045,0.026893934,0.038283527,-0.0659058,0.09343958,0.06736856,-0.027185963,-0.020340493,0.0038393799,0.0087971715,-0.042418122,-0.027806938,0.060783286,0.044852197,0.0060001356,-0.0825531,-0.02357488,-0.00031021747,0.03778648,-0.012779133,-0.09162926,0.018167928,-0.0386179,0.023010612,-0.08803665,0.01734995,0.04156149,0.034044992,0.02188575,0.018832779,0.033234943,-0.03229174,-0.024592161,0.001756083,-0.0065272874,-2.9958904e-33,0.014478939,-0.1263315,0.07036131,-0.033563238,-0.0027987808,0.009362106,-0.019409137,0.04899901,0.005721577,-0.031252373,0.020085722,0.017616844,-0.009372661,-0.046233892,-0.02693606,0.042525843,0.021503,0.015741581,-0.05382454,-0.049450137,-0.05764647,-0.011946124,0.060343336,0.013381905,0.020180952,0.028508373,0.07230338,0.08784454,-0.03018251,0.031544432,0.028304752,0.0756112,-0.07926963,-0.075664364,-0.13470514,0.03643682,-0.08803275,0.06561642,0.021099143,-0.024514483,0.042302918,-0.017379323,-0.02781608,0.05019697,0.0073506916,0.0616765,-0.00011046482,-0.018460896,-0.027725076,-0.08058406,-0.030261267,-0.02922822,0.05602242,-0.03429735,0.068476476,-0.0012683477,-0.033622086,0.008145102,0.04917423,-0.05613219,0.03708602,-0.0522737,0.017345319,0.06841297,0.0022265068,0.08794199,0.04346864,0.046369642,0.07575898,-0.03174422,0.040601764,-0.033963658,-0.012365642,0.07232698,-0.008571919,0.026560659,-0.113562986,-0.034644112,0.010848015,-0.012344817,0.027678855,-0.029041762,-0.099035606,-0.04162924,-0.06774448,0.00395816,0.09069417,0.1292043,0.062373888,0.007541005,-0.0644733,0.014661558,-0.06595614,0.049402565,0.037975084,-3.4166145e-08,0.069713905,-0.06961999,0.049105644,0.02560834,-0.1022499,-0.030153437,0.0040634996,0.08138829,0.031662095,-0.010132806,-0.024947774,-0.013762983,-0.013103921,-0.032702215,0.028370243,0.020061905,-0.026575174,-0.017668433,-0.02390261,0.0010865186,-0.043517932,0.07244276,-0.084216885,0.05379408,-0.0189317,-0.0062333937,0.0065921396,0.029946346,-0.052811317,-0.021772075,0.088902466,0.047469184,-0.07481005,-0.023360707,-0.0814553,0.008524411,0.023572769,-0.037296697,0.0552794,0.03421361,0.015329235,-0.016624749,-0.060593016,0.00082519517,-0.00015248718,0.03225392,0.051125344,0.0818984,-0.015315525,-0.08296414,0.1051059,-0.008027882,-0.035034385,-0.064211816,-0.16335876,0.06680032,-0.07508235,-0.078744166,-0.03768758,-0.0154641345,0.0018049951,-0.078081705,0.12072782,-0.037406806 +2.1.1.270,"The protein from the plant Pisum sativum (garden pea) methylates (+)-6a-hydroxymaackiain at the 3-position. It also methylates 2,7,4'-trihydroxyisoflavanone on the 4'-position (cf. EC 2.1.1.212, 2,7,4-trihydroxyisoflavanone 4-O-methyltransferase) with lower activity.",384,1.0,0.014272955,-0.04766722,-0.07306278,-0.07957222,0.007716256,0.14444892,-0.060544305,0.0033206842,0.02732958,5.3475702e-05,0.087888755,-0.0078092976,0.01042785,-0.12791163,-0.02677973,-0.0035690905,-0.07924535,0.029469542,0.00043708412,-0.02809163,0.059515946,0.009858729,-0.010242611,-0.0045183417,-0.02915409,0.044908777,-0.029310113,-0.040041324,0.039407093,-0.067034386,-0.028485069,0.07179809,0.016992632,-0.004685013,0.060985714,0.08928846,0.017473558,-0.09663286,0.027870875,0.01440057,0.096517466,-0.024916157,0.07701007,-0.09155845,-0.00042538482,0.045399886,0.0039847856,-0.029849175,0.08127069,-0.03103632,-0.01686869,-0.067344956,0.024130488,0.079529345,0.048073743,-0.0031591954,-0.0029710946,0.03449644,-0.013784889,0.036269348,-0.013298456,-0.0006200726,-0.00061912753,-0.023126086,0.026505977,-0.0254204,-0.047555808,-0.04515362,-0.009628425,-0.016370814,-0.0030448288,-0.0034462463,-0.010687627,0.053288415,-0.055985823,0.086389534,-0.05847731,-0.027684093,0.004849792,-0.043030728,-0.03261417,0.03341764,0.026021102,0.09268992,-0.014420746,-0.007936222,-0.02656772,0.033727124,0.04535794,0.034898728,0.07640291,0.06602818,-0.00950144,0.010687073,-0.013605846,0.055450067,0.004655963,-0.06670172,0.007677249,-0.02887945,0.06663382,0.0112421205,-0.091675796,-0.09143996,0.02206906,-0.009404201,-0.049342718,0.0145730125,-0.022647364,0.027483465,-0.00055352476,-0.032919273,-0.0133324,-0.019407816,-0.08718412,0.041514844,0.07623508,-0.075896665,-0.047150314,-0.13238023,-0.004589681,-0.027928859,0.08092659,0.072104454,-0.08226496,-0.06746004,-0.1696227,2.3465064e-33,0.055330236,-0.007675575,0.0270579,-0.013503103,0.0013268645,0.016720459,-0.018763816,-0.0034250368,0.011371739,-0.111568496,-0.11319878,-0.0070592295,-0.010129895,-0.013973612,-0.017363658,-0.01943075,-0.044434026,-0.03858889,0.021094311,-0.002146969,-0.004674516,0.020567406,-0.015138677,0.0069951615,0.0019227657,0.045456447,0.04294141,-0.09457569,-0.014605122,-0.040037006,-0.033381566,-0.07591414,-0.04781794,0.013771063,0.080855414,0.029849362,0.0014569405,-0.03135388,-0.06448602,0.1474393,0.04109735,-0.036890607,0.058010224,-0.016022097,0.0452797,-0.0072713117,-0.03227978,-0.012851905,0.05228598,0.054986022,0.04963042,0.003490874,0.068352945,-0.028186573,-0.114517294,-0.031056069,-0.01119653,0.031116039,-0.014071997,0.080204055,-0.0815151,-0.0029634489,0.04288014,0.006006704,-0.052820507,-0.01855617,-0.1365049,-0.02123213,0.0066369977,0.083409905,0.010658508,-0.070763186,0.09699233,0.041889373,0.11811601,-0.022608988,-0.056357067,0.031153623,-0.017144928,0.045264196,0.079859935,-0.0076138936,0.003813928,0.0014004095,-0.11223208,-0.0055498485,0.050966464,-0.02064209,0.008587952,-0.0027286308,0.101415716,-0.046429686,-0.018245501,0.050307367,-0.07293222,-2.8331405e-33,-0.013157022,-0.05065688,0.033675965,-0.043061838,0.011699948,-0.0033746057,0.040731203,-0.02179501,-0.03511412,0.012974846,0.08766032,-0.009381052,0.046201374,-0.00087428855,0.019958774,0.07277975,-0.014554066,0.0581515,0.00054053246,0.045069415,-0.06987915,-0.012559936,0.017464623,0.09677316,0.05299204,0.064132,0.07832583,0.012278587,0.011889013,-0.011000104,0.005313531,0.011871972,-0.08127213,-0.013991089,-0.014020959,0.050796866,-0.043368153,-0.043419555,0.012209871,0.032003615,-0.041808113,0.0067832083,0.054120652,0.025703913,0.07554814,-0.018081319,-0.022147665,0.0043445504,-0.094071425,0.05992643,0.05614181,-0.021018593,0.036763307,0.09637458,0.047460776,-0.05174332,-0.028854653,0.108678,0.015460196,0.016896565,0.0238249,-0.08831638,-0.043637097,0.014374688,0.013665825,0.071601324,0.02154389,-0.037583612,-0.047649417,0.045853753,0.055939168,0.01415687,0.060045965,0.03227141,0.010521908,-0.023675453,-0.003912282,-0.0010814592,-0.0819039,-0.017549569,-0.064881265,0.021594089,0.0028385315,-0.09657814,-0.0063055195,-0.007914304,0.037752744,0.10756982,-0.033596598,0.03957247,-0.03256375,0.049933586,-0.10820116,0.042269126,0.05983823,-4.4548106e-08,-0.0014891528,-0.110378966,-0.030775214,-0.038056247,0.016386805,0.0053020674,0.021181475,0.017880991,0.05124286,-0.055064842,-0.003462295,0.016780373,-0.01557523,-0.01802357,0.030649852,0.015196892,-0.025370697,0.057141412,0.01866373,0.06465639,-0.035213325,0.042536717,-0.07577355,-0.00422223,-0.07264168,-0.009567655,0.04075359,0.037399784,0.037575368,-0.02217524,0.09109112,0.0516856,-0.027855547,-0.090290084,-0.066525176,0.077584505,0.06535844,-0.023402026,-0.011745881,0.05247257,-0.07095605,-0.019435894,-0.04891908,-0.007231832,0.02778213,-0.063789345,-0.02534381,0.062156137,0.054168403,0.022022402,0.018148942,-0.006838783,0.017367,-0.12438528,-0.046453524,-0.069894575,-0.009881914,-0.048367795,-0.019048102,-0.009862553,-0.06387751,-0.03235841,0.17549548,0.04503729 +2.1.1.271,"This enzyme, which participates in the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway, catalyses the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A. See EC 2.1.1.133, precorrin-4 C11-methyltransferase, for the equivalent enzyme that participates in the aerobic cobalamin biosynthesis pathway.",384,1.0,-0.058642764,0.07285062,-0.15185092,-0.0057039834,0.090974644,0.07436515,-0.10034985,0.0070757954,-0.0009539548,-0.046728935,-0.022328934,-0.06730126,-0.0843449,-0.015277251,-0.04429705,0.022003,-0.04815576,-0.018506698,-0.08513204,-0.043844957,-0.01806443,-0.024771104,0.034918346,0.038668234,-0.0019674336,-0.051965322,0.020514328,-0.0043349047,0.007938609,0.042028204,-0.03919058,0.0179499,0.037556913,-0.0155880945,-0.01340988,0.08451595,0.012497685,-0.021985695,0.08489728,0.026182808,-0.011848157,0.031809606,-0.006884645,0.0073194103,0.009305821,-0.047977585,0.031085275,0.02416017,-0.01298992,-0.018353265,-0.034522206,-0.003146747,-0.066138275,-0.001680897,0.01748716,0.0149500435,-0.05191325,-0.0949313,0.07530701,0.007380325,0.048991,-0.08435702,-0.01795688,0.031622227,-0.0069447733,-0.014911191,0.05906936,-0.041684955,0.04530423,-0.060291186,0.0028812755,-0.07179519,-0.035778757,-0.019732134,-0.03303204,0.06858421,0.025111344,-0.041734368,0.037326593,-0.012449152,-0.013956266,0.09250342,0.008594673,-0.014445688,0.059532683,-0.014333432,-0.035135947,0.012943576,0.035440106,0.0781706,-0.040639788,0.032229926,0.0185103,-0.0043051564,-0.16121306,0.012812079,0.08882913,0.034881458,0.024510993,-0.012518731,0.051937513,0.08213719,-0.06379116,-0.020726778,0.012199616,-0.032618348,0.08753704,0.16535492,0.016906796,0.03428622,-0.0050471956,0.0372145,-0.03545443,0.017931132,0.010784249,0.12101299,0.020914895,-0.024760017,-0.05391803,0.06183742,0.022165848,-0.032207247,-0.008274969,-0.004711606,-0.045570485,-0.09845191,-0.04466675,1.5824626e-33,0.11923339,0.012573134,-0.008916588,0.029312532,-0.023829872,0.040148396,-0.14877161,0.04513053,0.02567132,-0.039546125,-0.009603682,-0.06874322,0.023527736,0.027621448,-0.114023626,-0.07177982,-0.024784015,-0.09132258,0.041716013,-0.013161432,-0.035775516,0.06399798,-0.029802829,-0.011628378,0.013976894,0.06657009,-0.010952304,0.063904576,0.050489966,0.014053445,0.010528631,-0.057287455,-0.08761361,-0.06443286,0.05882739,0.03283342,0.005021132,0.07121526,0.034438673,0.04494077,0.028237103,0.022495411,-0.07455357,-0.024500282,0.036144327,-0.05539384,-0.049338967,0.08105184,0.028653657,0.014805834,-0.021457916,0.009135639,0.090521246,0.032055665,-0.06177556,0.021667846,0.031545546,-0.029492807,-0.024868777,0.057771973,0.08931758,-0.012814719,-0.018257132,0.123934545,-0.0027824554,-0.07769917,-0.046221536,-0.050686028,0.040307734,-0.010025766,-0.045922965,-0.06084224,0.058204766,0.047217987,0.051782332,-0.009273658,-0.06374712,-0.056689553,0.012086801,-0.02376574,-0.035155352,0.032247663,0.0044873124,-0.038072065,-0.061590154,0.05392884,-0.037472934,-0.07248278,0.008421641,-0.07325962,-0.013931784,-0.024929289,-0.0010458769,0.0042981454,0.024675287,-3.477288e-33,0.078622825,-0.08014181,0.039624266,-0.13485377,-0.052352007,0.07077381,0.06958848,-0.1250585,-0.056967825,-0.0080788825,0.104139395,-0.024548322,0.0009982905,0.03410121,0.040383242,0.044876195,-0.031533472,0.082207754,0.013831289,0.028599378,0.014860586,-0.010611677,-0.0331295,0.0015321655,0.0040856805,0.06011717,-0.0038179962,0.006744532,0.07339431,0.07330477,-0.060543124,0.0029951544,-0.025352426,-0.014346533,-0.015589453,0.060422666,-0.020166399,-0.012477472,-0.03302587,0.0028351278,0.025926972,-0.053967748,-0.06447789,0.03815785,0.023211915,0.045391817,-0.050795674,0.062499765,-0.047235493,0.042948805,0.060702454,0.013600091,-0.056836538,0.031572063,0.09559391,0.026556762,0.044769205,-0.045503784,0.036192533,-0.07003374,-0.06061843,0.043421324,0.014691078,-0.040585525,0.046742912,0.025481531,0.017445473,0.0650042,0.035089795,0.031251352,0.068112746,0.070951216,-0.013422786,0.006900961,-0.108086206,-0.04815282,-0.015321394,-0.04709319,-0.056982886,-0.042646352,-0.04501261,-0.021075016,0.06892214,-0.043920122,-0.095169105,-0.07432867,0.08108137,0.040013563,-0.014302701,0.08898213,-0.021045333,0.0006277007,-0.04144074,0.007922166,0.009413508,-3.3547895e-08,-0.022567386,-0.06841665,0.054814667,0.00281255,-0.021053843,0.06892488,-0.03149033,-0.05236951,0.0709119,0.008693122,0.023335375,0.06992314,0.043639842,-0.013055713,-0.09584193,0.009633059,-0.04903283,0.012564597,0.022584312,0.026952047,-0.08039258,0.041603055,-0.0018163504,-0.0527714,0.039977305,-0.12952773,-0.07258185,0.100498796,0.024877096,-0.03966068,0.020992069,0.059715796,0.07815414,-0.086391084,-0.019003274,0.04503042,0.023186998,-0.033909403,-0.04716454,-0.0137870805,-0.026535401,-0.04454506,-0.099796385,-0.0052763564,0.030437492,-0.05855327,-0.028501526,0.06649252,-0.0065272525,-0.003792417,-0.0002565473,0.0023252543,0.0011451405,0.0057306704,-0.026050167,0.029966645,-0.044326317,-0.039141197,-0.025362065,0.018859819,-0.015706372,0.038365476,0.05204306,-0.119265445 +2.1.1.272,"Isolated from the bacterium Bacillus megaterium. The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin. See EC 2.1.1.131, precorrin-3B C17-methyltransferase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.",384,1.0,-0.05453983,0.03897587,-0.16063437,0.013679335,0.09622957,0.03873765,-0.09747483,0.038127333,0.014622814,-0.056341343,-0.012259212,-0.07954631,-0.0073872413,0.00701335,-0.04460388,0.023306377,-0.034944084,0.0030884708,-0.014223077,-0.055821184,-0.04536091,0.06969278,-0.020948693,0.016208913,-0.0023246508,-0.01560452,0.03359815,-0.010346439,-0.0321278,0.006853977,-0.0520064,0.026540192,0.042802002,-0.058941748,0.016215019,0.14097878,-0.021150954,0.031295713,0.073950715,-0.025648445,0.002674382,0.069720194,0.036681823,-0.014470351,-0.00074116077,0.01997519,0.019952133,0.038413506,0.0010484708,-0.03243742,-0.065627985,0.010068106,-0.03111462,0.032435223,0.024219353,-0.012612624,-0.047229197,-0.117701896,0.055181477,-0.0036262607,0.051949807,-0.08617308,-0.006591174,-0.0052499855,0.026223252,0.00902965,0.06930802,-0.044030175,0.026291132,-0.08231404,-0.011349079,-0.015419933,0.0016725179,0.016827064,0.009741303,0.07694981,0.024310471,-0.03929142,0.04425069,-0.011351825,-0.008142524,0.025051003,0.03972083,0.08437876,0.054506265,-0.042710204,-0.020942047,-0.0075934567,-0.0070877257,0.11358151,0.0023066907,0.058779895,0.031994514,0.006090671,-0.15950637,-0.026736734,0.014835074,0.018110525,0.038433,-0.010108026,0.0031307954,0.06648794,-0.052267637,-0.045999102,0.016110951,-0.04672072,0.044274703,0.15142065,0.09025745,0.046396524,0.03283143,0.061784934,0.008047887,-0.033996146,-0.0048333583,0.11250245,0.043928258,-0.04514784,-0.104336046,0.036882848,0.066443495,-0.012043239,0.0006937999,-0.029351175,-0.031944185,-0.061173562,-0.06204116,3.217862e-33,0.084181905,0.013638665,0.02751662,0.022918578,0.03083872,0.021563984,-0.12082037,0.024085997,-0.004643146,-0.054484088,-0.062100932,-0.09371685,0.0007188912,0.017465526,-0.02933888,-0.09933244,-0.02219077,-0.06434344,0.033314634,-0.018420469,-0.03343363,0.097085,-0.042834617,0.03260155,0.029609669,0.090528764,0.014323355,0.04367686,0.04860346,0.002437421,0.029902421,-0.06707947,-0.12895899,-0.048746355,0.058440298,0.010773819,-0.07640941,0.008913393,-0.01661404,0.06952991,0.007285809,0.05095746,-0.1024928,-0.036965545,0.10400558,-0.043119676,-0.026080403,0.09457554,0.03589938,0.03207819,-0.014087835,0.012720738,0.07729159,-0.0012412511,-0.08764489,0.0049107857,-0.004753985,0.011986044,0.03415691,0.08267509,0.065629244,0.053735364,-0.025671726,0.12635274,-0.006025185,-0.03424758,-0.031891532,-0.07079762,0.00622024,-0.014554895,0.003857557,0.025931615,0.09146811,0.01221375,-0.009305072,-0.03351719,-0.040060185,-0.05255941,0.018043777,-0.102129065,-0.03514191,-0.0027999426,0.03459083,-0.03423783,-0.08060404,0.07189976,-0.006845499,-0.05877374,0.023642655,-0.0084102405,-0.028030135,-0.043663032,-0.09740042,-0.0033078613,-0.034116965,-3.1531648e-33,0.13479896,-0.095982924,0.10689887,-0.11846831,-0.058206387,0.040634412,0.025215456,-0.020824723,-0.02136385,-0.042646278,0.101159655,-0.043749005,0.046437558,-0.027457591,0.036368992,0.05406257,0.016566252,0.09326188,-0.007473232,-0.009731972,0.0034466335,0.006985234,-0.055624325,-0.00048536705,-0.027940063,0.087050214,-0.018165756,0.019578736,0.057130963,0.051927935,-0.04613748,0.022556556,-0.02410677,-0.041203987,-0.05641372,0.10131575,-0.031180836,-0.017846137,0.004375155,0.029829353,0.0116267,0.029808981,-0.038414784,0.040690403,0.02941672,0.067319706,-0.05702117,0.040045276,0.012520203,-0.0016699494,0.08659969,-0.010069434,-0.04442982,0.0069221184,0.055410895,0.014228421,0.019625057,-0.04040814,0.008804614,-0.10992372,-0.016552795,-0.06837897,-0.002194894,-0.06169331,0.07886651,0.036630943,0.042869918,0.07789784,0.06319934,0.00025346366,0.06087866,0.057319432,0.029026996,-0.028966254,-0.061884105,-0.0029384736,-0.018533451,-0.014741364,-0.02043711,-0.014637099,-0.011149089,0.012016392,0.07487329,-0.029043512,-0.029061558,-0.06851563,0.07309918,0.05985245,-0.012493866,0.04693398,-0.074652985,0.004905139,-0.014061839,-0.015165256,0.053188704,-3.9499504e-08,0.060596634,-0.11538548,-0.004040826,-0.014270616,-0.0068700714,0.0604024,-0.028692955,-0.009421751,0.0276321,0.011059937,0.004568644,0.05980631,-0.012101411,-0.072766736,-0.02120038,0.013188347,-0.064398386,-0.026784489,-0.00025552098,-0.011306039,-0.09184792,0.025712706,-0.03211729,-0.017909857,0.041273974,-0.08431668,-0.02204778,0.025532907,-0.0044404897,-0.052882317,-0.009480133,0.014355929,0.035859555,-0.06679403,-0.034315176,0.017360521,-0.048501723,-0.024501195,-0.0047993013,0.0023735983,-0.040674277,-0.042628158,-0.10594044,0.044772528,-0.027373005,-0.056680582,-0.061596494,0.08657882,-0.0479965,-0.046383385,0.027239017,-0.013976562,0.041853327,0.0036466264,-0.05250396,0.074052595,-0.028031282,-0.02463697,-0.045881808,-0.011348612,0.013550065,0.013196736,0.09372139,-0.07262457 +2.3.1.223,The enzyme acts in the opposite direction. The enzymes from the bacteria Escherichia coli and Pseudomonas sp. Y2 also have the activity of EC 2.3.1.174 (3-oxoadipyl-CoA thiolase).,384,0.99999994,-0.06327073,-0.0930779,-0.062074058,-0.011655687,0.045292735,0.002111772,-0.12676124,0.03772014,0.063974954,-0.026957825,0.06383241,-0.06658108,-0.04103973,0.081869766,0.012556263,-0.025333108,-0.06014921,0.0165951,0.06047028,-0.04079692,0.07527878,0.05572234,-0.021051137,0.044558845,-0.03647116,0.006624979,0.056793857,-0.0010632063,-0.029405782,-0.08354726,-0.053741917,-0.06750679,0.05940405,-0.05061715,0.022467624,0.03827636,-0.012598857,-0.0617322,0.07134998,0.02761529,0.055566747,-0.018160366,-0.04615324,-0.062446564,-0.011298888,-0.043438476,8.3957515e-05,0.00991249,0.052956488,-0.008272763,-0.03614642,-0.071191974,-0.04735863,0.09263319,-0.062291447,0.06748764,-0.00036328,0.030722694,-0.013420829,0.014065847,0.05768788,0.010253498,0.028147884,0.033263367,0.018249609,-0.09164219,0.043170888,-0.031470347,-0.03525087,-0.04442705,-0.051763687,-0.05459663,0.03414273,0.010132708,0.038249455,-0.031041058,-0.0021709122,-0.018252345,0.02307265,-0.04087705,0.022483313,-0.045347136,-0.03419959,0.10206281,-0.006272276,-0.03185663,-0.02959529,-0.039014738,0.014394448,0.026055155,0.02741575,-0.034870155,-0.02442742,-0.008581265,-0.017414195,0.051784493,0.00032764202,0.07378091,0.045554735,-0.05901348,0.015963811,0.09707278,-0.06407188,-0.04456242,0.063654356,0.0096988,0.00833633,0.044149294,0.031635784,0.010119169,0.015443623,-0.05633739,0.07949107,0.008090453,-0.011920911,0.07745791,0.010486556,-0.0075631784,-0.0738578,-0.029283859,0.0044215857,-0.05358021,0.05597419,0.06944705,-0.011304194,0.017990619,-0.081666,-1.09801755e-35,0.06648739,-0.0146477595,0.052703395,-0.07688658,0.0033638212,-0.055939425,-0.07424821,0.089593776,-0.025784178,0.0149226915,0.0004382937,0.0060756598,0.066599905,0.028234642,-0.037259,-0.069259375,-0.034708098,0.0066040433,-0.01824594,0.0220208,0.039459765,-0.00548886,-0.04094824,0.029782113,0.047595307,0.016721101,-0.046863806,-0.019732747,0.04953819,0.033836156,0.007837307,-0.09204763,-0.075777486,0.0006705973,0.037828483,-0.01119709,-0.046931773,0.01557552,-0.026669383,0.051866848,0.011959229,0.036175177,-0.02407628,-0.070422605,0.05932688,-0.05580354,-0.020260124,0.13866965,0.07555553,0.057048175,0.040288232,-0.09903561,0.087304585,-0.044181477,0.032075617,0.048414413,-0.0045137512,0.06304596,0.013206844,0.025281208,0.013143579,0.092147656,-0.05976017,0.013199662,-0.08846066,0.06772995,-0.07243422,-0.06368517,0.005317431,0.07877149,-0.103256606,0.09398294,-0.0007899882,0.008599778,0.025841152,-0.040273372,-0.10707092,0.015754187,0.07438228,-0.038253233,-0.042187613,-0.004765246,0.019221516,-0.002958813,-0.018953418,-0.0043714405,0.0042089117,0.013038041,0.010245984,0.065602124,0.08340034,-0.037792,-0.037272345,0.07162814,0.029832568,-1.2182285e-33,0.06215373,-0.07873996,-0.015524569,-0.11842316,-0.086275935,0.04019333,-0.016552765,0.04315326,0.055822603,0.012122158,0.07474466,0.021894386,-0.004618836,0.003127446,0.05817282,0.025994368,-0.0014012454,0.019704098,-0.03407648,-0.028379919,0.0048083193,-0.0059366985,0.02269227,0.007575879,0.055339184,0.02629442,-0.015546093,0.09467245,0.027031526,0.039229628,-0.037440315,0.0019409375,-0.034635313,-0.016094852,-0.07133781,0.029661786,-0.06596061,0.00220413,0.077272564,-0.023565538,0.008729056,0.04764538,0.043552194,0.08029403,-0.01742363,0.10392902,-0.02432324,0.011242161,-0.015072134,-0.090944596,-0.054485608,-0.010342835,-0.005421467,0.060959183,0.0028803193,0.051080197,-0.051285155,0.024276242,0.0035675014,-0.054883204,-0.04214991,-0.07064574,0.018127002,-0.054694813,-0.011347242,0.017727451,-0.055196695,0.057739317,0.045191288,-0.0143159,0.10755567,0.058463193,-0.044088524,-0.06507249,-0.052437603,-0.05405761,-0.04429536,-0.05663415,0.024026377,-0.034621857,-0.00048873323,0.06290182,-0.027681412,-0.08780335,-0.059827283,-0.051738918,0.01402932,0.106598556,-0.013653515,0.037126,-0.04533822,0.0110577345,0.0053264205,-0.0027898513,0.08465912,-3.104805e-08,-0.04219904,-0.06467945,0.140737,0.024115795,0.060649082,0.07243407,0.0033744532,0.056418475,0.054295417,-0.0065888134,-0.036846023,0.09924929,0.047562588,-0.053655583,0.045030236,-0.00453871,-0.011869907,0.016280277,-0.0032046614,-0.04685476,-0.004066128,-0.07716094,-0.06966316,0.05612954,0.017984482,-0.020647189,0.009223122,-0.052187208,-0.086014844,-0.022543613,-0.04085669,0.014378226,0.014959189,-0.016508607,-0.09985479,-0.025097415,-0.02553026,-0.01322675,-0.069487676,-0.002467525,0.04735186,-0.03692621,-0.12597218,-0.0056355945,0.049660977,0.03953062,0.0761724,0.013382219,-0.011874186,-0.10648104,0.011602627,-0.098085426,0.04362403,0.039712343,-0.06955029,0.00841964,-0.032137536,-0.085723266,-0.065188035,0.04738854,0.010871153,0.09077499,0.20058486,-0.004814061 +2.3.2.20,"The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue [2]. The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L-phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl-L-tyrosyl) [1].",384,1.0,-0.02795057,-0.008477506,-0.09547116,-0.046297118,0.03971096,0.042448577,0.011158633,0.04007681,0.10650643,-0.019176845,0.06889808,-0.029014884,-0.019568184,0.100055344,-0.023992686,-0.013404933,-0.09571864,0.0028221682,0.054856315,0.007558101,0.08183265,0.107622795,-0.022471992,-0.010042771,-0.021213576,0.012918135,-0.0013066551,-0.018441167,-0.031085515,-0.06483163,0.019929776,0.039534163,0.009762149,-0.06133406,0.12819766,0.02236698,0.005566231,-0.079942085,0.09479683,-0.03357611,0.019798886,-0.036600407,0.039354425,0.0075972085,-0.01724201,0.050014865,0.06679864,0.049626507,0.03133443,-0.044781722,-0.011203581,-0.06651055,-0.047388118,0.014642064,0.0047619417,0.07775202,-0.07704251,-0.00042103816,0.03878739,-0.09597029,0.019219894,0.047810074,0.031136913,-0.011103709,-0.030091533,-0.08963686,0.0435273,-0.12106211,0.06757904,0.011094356,-0.010676359,-0.06566591,0.043024976,0.0060004634,0.015982812,0.12132924,-0.054017108,0.026848996,-0.015065773,0.011579545,0.003083976,0.011365821,0.023778077,0.10815041,0.00015519737,-0.054398112,0.01616523,-0.02441585,0.11537336,-0.01817445,0.04660651,-0.014760023,-0.049819734,-0.026239622,-0.06706249,-0.025038632,0.013650143,0.030390412,-0.027527565,0.050277904,-0.05144738,0.026637577,-0.0024629314,-0.031600017,-0.000410811,0.015499624,-0.023457883,0.058623627,0.046677884,-0.060805764,-0.030394642,-0.016975721,0.05463765,-0.022915618,-0.014885938,0.015410625,0.011224862,-0.048707984,-0.023278777,-0.06314977,0.0059979204,-0.02127866,0.010450934,0.06638176,-0.015502208,0.062672906,-0.11652682,2.7676e-33,0.060305536,0.02910082,0.11630659,-0.08137199,0.047379594,-0.08878085,-0.069573045,-0.005245752,0.024671244,-0.081830345,-0.10962644,-0.09578198,0.043927435,-0.010747516,-0.0147332875,-0.0067721503,-0.019307597,0.027270475,0.09329942,0.035831142,0.018619277,0.053773873,0.03243243,0.011830999,0.019293617,0.08249406,-0.009836187,-0.042036317,0.04610264,-0.0051050605,0.02456736,-0.08027018,-0.06704504,-0.03058076,0.044071343,-0.010495837,-0.083296746,-0.0653102,-0.008023019,0.022546105,-0.02616661,-0.022394177,-0.035664793,0.030213296,0.022921786,-0.06938198,-0.06006031,0.071747035,-0.039902102,0.01672045,0.010020817,-0.05850987,0.034360316,0.023809884,-0.10787285,0.014713861,-0.0012065549,0.0041295975,0.031623695,0.025573976,0.038909484,0.018586718,-0.0123715,0.014193298,0.053485632,0.030902172,-0.039779756,0.010005528,0.015582029,0.042591847,-0.03760597,-0.010245201,0.08257386,0.013704484,-0.007345109,-0.025954569,-0.11282678,-0.025555177,0.075738646,0.072715454,0.037328817,-0.079026856,-0.038564045,-0.04327797,-0.06824801,0.012436918,0.01631484,-0.0870269,-0.013293708,0.08420249,-0.0011615179,-0.09607478,-0.01868112,0.009587448,0.007791308,-4.5575947e-33,0.0678669,-0.0933648,0.034699984,-0.04540146,-0.061781432,0.049350075,-0.021513397,-0.06452613,-0.016760644,-0.003272506,0.014701635,-0.010903274,-0.00054984115,-0.02495689,0.009997118,0.018655611,0.052167796,0.105245665,0.011392173,0.046408635,-0.0057647857,0.004008936,-0.010374332,0.004749784,0.09607763,0.0022603325,0.043004256,0.06441824,-0.03923595,0.07491825,0.008569975,0.014211435,0.020447483,-0.08183756,-0.027655818,0.069345154,-0.05126188,-0.062390458,0.11976754,-0.043908995,0.07408626,-0.025475716,0.054893915,0.081891015,0.08172152,0.06391863,-0.079393074,0.029340055,-0.016224144,-0.053476788,0.02292115,0.019667227,-0.02367946,-0.10742189,-0.003395924,0.09026156,-0.01860691,0.017480087,-0.029075189,-0.011212413,-0.0070189135,-0.07402221,-0.06061425,0.060983766,0.06919247,0.034341127,0.016751694,0.05441308,0.08310894,-0.080148466,0.028473614,0.03510105,0.05253836,0.064507246,-0.008093584,-0.04414847,-0.044315618,0.03019401,0.012315639,-0.025941178,-0.060926586,-0.07065938,0.019858802,-0.047797695,0.037229948,-0.03590887,0.024433173,0.09515449,-0.03190226,0.035146996,-0.03458633,0.03433614,-5.380483e-05,0.07993426,0.07317955,-5.1220233e-08,0.07767923,-0.08820914,0.022734048,-0.033865415,0.01474368,0.039046768,0.0055573853,-0.06927512,-0.0068854652,-0.03104871,0.011832329,-0.009344627,-0.029698601,-0.03504272,0.0060918545,0.056673247,-0.08967721,-0.048982054,-0.048113182,-0.021588704,-0.067024805,-0.0021915222,-0.062928274,0.048621166,0.023211315,-0.07831154,0.078210644,0.04421834,-0.061984055,-0.07456756,0.027290693,-0.052024458,-0.07995534,-0.004749267,0.01677157,0.023843186,-0.05700118,-0.05705516,0.066141486,0.052544348,-0.07639689,0.023238594,-0.07447889,-0.018552817,0.012943656,0.096369535,-0.039520197,0.019959878,-0.12583053,-0.05365608,0.043200366,0.037800834,-0.030338863,0.0358827,-0.1034937,0.06998628,0.031686034,-0.04692404,-0.0040213712,-0.011235069,-0.011380467,-0.021519573,0.09466591,-0.040654663 +2.3.2.21,"The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1].",384,1.0,-0.02202941,-0.0053422023,-0.05303114,-0.047372628,0.031205846,-0.0007051341,0.09988026,0.10232111,0.06371811,0.05175213,0.00820166,0.024533335,0.03902516,0.07866691,-0.010387865,0.035743367,-0.053251065,-0.0036580856,0.04422422,0.012258131,0.056572147,0.1003535,-0.00018547941,-0.026393436,-0.045598768,0.020587515,0.017797634,0.033125717,-0.022526842,-0.07680722,-0.013806657,0.028690625,-0.011431756,-0.07303403,0.09229705,-0.00708381,-0.011805438,-0.08731573,0.07331657,-0.047682185,0.058466673,-0.02288934,0.027689196,-0.016864287,0.017334133,0.04755483,0.036087178,0.054377384,0.019650608,0.018259116,0.00513351,-0.04451979,-0.036516465,0.012015863,-0.01829059,0.0559289,-0.12005933,0.006663438,0.061787285,-0.057243805,0.004831588,0.05810127,0.016826095,0.031905163,0.057819746,-0.082340926,0.009293983,-0.10049106,0.047357474,0.0010188094,-0.01035396,-0.053018726,-0.00043238045,0.038195867,0.006601526,0.07647633,-0.026366208,0.011122623,0.006479595,0.026022952,-0.054743886,-2.5457823e-05,0.005423786,0.087834105,-0.030223534,-0.015640019,0.08889711,-0.008928581,0.11885547,0.0062490604,0.048679005,-0.02659177,-0.0033323043,-0.0021732186,-0.08737738,-0.027745979,0.09818586,0.034192346,-0.0072404137,0.05774223,0.016437732,0.042030003,-0.011284785,-0.038597964,-0.0019740274,0.024377452,-0.027605783,0.04921909,0.04575137,-0.040200375,-0.07723398,-0.019580051,0.06733671,-0.020378664,-0.029809996,0.012269544,0.060950637,-0.023050759,-0.017117182,-0.0686017,0.044173516,-0.054607257,-0.043643754,0.040251557,-0.04473511,0.065936595,-0.08582131,-7.011553e-35,0.048945747,0.014904614,0.1255435,-0.044316612,0.019919796,-0.08829453,-0.059055466,-0.028089864,-0.025277916,-0.04328962,-0.13911216,-0.08407825,0.05661807,0.01190253,-0.095885694,0.015778376,-0.01535974,0.017325629,0.089770794,0.07585156,-0.0044244365,0.07933183,0.049428817,0.044959795,-0.002971436,0.1104512,-0.02400989,-0.03330165,0.008246623,0.005853398,0.0044123624,-0.037042525,-0.0722704,-0.021095613,0.019173102,-0.035579495,-0.06083155,-0.04652436,-0.0057764086,0.004559534,0.026872808,-0.020711605,-0.039919,0.01250045,0.040215325,-0.084919155,-0.056368567,0.065573275,-0.046333265,-0.010036093,0.04845642,-0.07392637,0.004908564,0.012054666,-0.05582044,0.0051319543,-0.0026255536,0.011148424,0.058710903,0.037256286,0.059673253,0.021185944,-0.022811428,0.07703769,0.011169411,-0.0046169767,-0.05315055,0.005074383,0.007937994,0.017738616,-0.00728811,0.008345379,0.078064784,-0.0115374485,0.040646713,0.012617405,-0.10576196,-0.08666741,0.05226421,0.019086737,0.042934336,-0.0660158,-0.023407718,-0.009141666,-0.051153693,-0.061227,0.0142341675,-0.070954084,-0.061136585,0.069161996,-0.006914628,-0.08465225,-0.031033697,0.0022793673,-0.027475953,-1.5009824e-33,0.058379356,-0.096976236,0.04497864,-0.059659332,-0.03181721,-0.0072120423,0.034409095,-0.089749455,-0.0033185943,0.037455983,0.031711433,-0.04039763,0.028702348,-0.01382166,-0.046976525,-0.034018483,0.07777345,0.07971424,-0.025216317,0.007326063,-0.03930352,-0.0007780505,0.038472798,-0.021064142,0.048213433,0.027852187,0.02301576,0.033325497,-0.047374237,0.114980906,-0.021503638,0.03215979,0.0649569,-0.071410224,-0.036901876,0.06349358,-0.013988894,-0.09498467,0.11787923,-0.09493463,0.019918855,-0.022006245,0.04568977,0.041986965,0.072784536,0.01969485,-0.0731518,-0.020632545,-0.04685479,-0.007086516,0.014342621,-0.014550795,0.009962475,-0.090293854,0.010572384,0.06532717,-0.035192568,-0.0054688132,0.015074527,-0.011600365,-0.0067858347,-0.020482799,-0.054821752,0.0348994,0.06717073,0.063280515,0.0031793572,0.07908853,0.07109141,-0.078278534,0.066610925,0.0729817,0.065212764,0.04233476,0.055993184,-0.060459226,-0.009293912,0.01975983,0.025363164,-0.054150537,-0.13677976,-0.023006251,0.0076904777,-0.05011425,0.0035695406,-0.050880283,-0.015356566,0.124706335,-0.054191098,0.023184529,-0.0018873056,0.045374773,-0.041884623,0.10623403,0.07960784,-3.951234e-08,0.03415309,-0.0815943,-0.0019235122,0.0012614991,0.0021122957,0.10316238,-0.016840968,-0.032556035,0.052396446,-0.05365517,0.0548071,0.03129227,0.021474212,-0.05929335,0.024827627,0.05775866,-0.08540328,-0.08921335,-0.07647469,-0.049334105,-0.03979854,0.024394251,-0.0147507,0.024642784,0.018255653,-0.09073701,0.024084965,0.045652237,-0.07716003,-0.083714314,-0.0027463823,-0.028585048,-0.08458568,-0.0608228,-0.0031846038,0.041783392,-0.027343633,-0.034190714,0.10077255,0.040464792,-0.057447743,0.02092406,-0.08526408,-0.010906635,0.009516195,0.07183244,-0.073377885,0.027107231,-0.08989434,-0.07597587,0.029374197,0.034182165,-0.0423474,0.0014339465,-0.072715975,0.06630595,0.011155995,-0.013188337,-0.0018095475,-0.04439452,-0.021734752,-0.00028356104,0.09549397,-0.042869538 +2.3.2.22,The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue [2]. The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L-methionyl) [1].,384,1.0,-0.048362456,-0.019797444,-0.010419569,-0.05063747,0.013483983,0.021259515,-0.009012483,0.071643725,0.068134576,-0.008342085,0.03778651,-0.053489033,0.041780043,0.084386125,-0.0105475355,0.0012986087,-0.09172075,0.025876502,0.006708986,0.038899478,0.09679962,0.088403724,-0.05992236,0.0058347904,-0.03938128,0.012958633,0.04236142,-0.035617318,-0.02473441,-0.049503583,-0.014998625,0.020730173,0.015335554,-0.06606516,0.10004991,-0.03414465,0.019955708,-0.01564077,0.0989494,-0.04264808,0.015479634,0.005990319,0.044441316,-0.06250575,0.0008348722,0.05166799,0.07185357,0.014032297,0.0032674337,-0.035686135,0.00805491,-0.015469963,-0.04905126,0.038521837,-0.02391941,0.02650872,-0.12564184,-0.0393928,0.055593852,-0.052296594,-0.041190453,0.044634163,0.027002303,0.011047247,0.01863503,-0.09863479,0.01240767,-0.090814345,0.0090838885,-0.0065737073,-0.0052014166,-0.057520933,0.059173096,0.037634745,0.06634877,0.089245476,-0.06646344,0.031317744,-0.006584248,-0.04007962,-0.008210677,-0.020871645,0.0036867864,0.14845714,-0.044698086,-0.04408691,0.05972416,-0.0049232156,0.09484691,-0.0124681685,0.038171213,-0.016817376,-0.050284456,-0.03834527,-0.08037506,-2.2346974e-05,0.020667233,0.042421844,0.0073106415,0.02735439,-0.03639696,0.04025577,-0.022125766,-0.047154125,-0.007137179,-0.028443003,0.03369354,0.07349112,0.07999517,-0.043022905,0.0038847772,0.0014915131,0.05356552,-0.046584602,-0.053903505,-0.009303903,0.009527785,-0.042440552,-0.024382522,-0.11751353,0.035881985,-0.03969558,-0.0126682175,0.033819143,-0.018268928,0.050198253,-0.083428875,1.25271845e-33,0.057162076,-0.00746313,0.09707363,-0.038814206,0.012763289,-0.11091664,-0.059789147,9.416723e-05,-0.004695757,-0.045651138,-0.12539145,-0.078433104,0.048139762,0.019056985,-0.036732417,0.035821468,-0.01201398,-0.038492374,0.06850534,0.010102969,0.020244543,0.042496152,0.07878872,0.045477413,0.029807147,0.07684674,0.028670935,-0.039863463,-0.0021877044,0.003575713,0.040753204,-0.07963567,-0.039683104,-0.014347567,0.05384381,0.024815142,-0.07090165,-0.010252849,-0.06823882,0.03190969,0.018478153,-0.00024310358,-0.06025677,0.0010132513,0.033415295,-0.041015204,-0.061354898,0.10003651,-0.0339465,0.0468167,0.061125323,-0.04141639,0.026672877,0.011321764,-0.06561416,0.029505339,0.0059926286,-0.013472796,-0.004157953,0.05525183,0.060393464,0.07226498,-0.07251132,0.07045252,0.027040172,0.031216407,-0.057446133,0.0018531467,-0.005243074,0.012350235,-0.042580944,0.01899535,0.06774565,-0.0046054125,-0.020422215,-0.0042708535,-0.08559197,-0.055803776,0.03105938,0.061151695,0.057339944,-0.09012106,-0.00064152724,-0.016340664,-0.07639793,-0.048213296,0.024580577,-0.05902383,-0.030587694,0.06862222,0.023108931,-0.10618489,0.019273536,0.051333673,-0.016689785,-2.9650805e-33,0.0667538,-0.10522929,0.09186882,-0.05284294,-0.060071167,0.036030974,0.032909706,-0.06640645,0.003023879,0.015095775,-0.016340032,0.01192838,0.026356153,0.018134065,0.014961026,-0.0050156843,0.06318501,0.07197353,0.024318902,0.023261277,-0.004594518,0.042584173,-0.00055328134,-0.026430108,0.09007007,0.02442308,0.07791112,0.123372644,-0.053748526,0.010816853,0.01504392,0.02458861,0.086959735,-0.10736306,-0.066376604,0.08311702,-0.007839443,-0.06104195,0.07524261,-0.06895199,-0.015248271,-0.03039791,-0.008762096,0.06497592,0.101916194,0.04356168,-0.053256482,-0.007011008,-0.008271734,-0.026198894,0.021916613,-0.03640201,0.018892176,-0.13396099,0.033889934,0.048514064,-0.06683708,0.052091733,0.024569621,-0.07829722,-0.0041740434,-0.063872,-0.015131879,0.056684513,0.041492417,0.07366993,0.021403918,0.017711097,0.02894971,-0.0756698,0.023359926,0.062373914,0.03299359,0.030012093,-0.0018684705,-0.017429575,-0.042257953,-0.017147647,0.0028989036,-0.0006264453,-0.10660886,-0.04569732,-0.010263472,-0.028335178,0.028411636,-0.02479582,-0.009704319,0.104410715,-0.006682588,-0.011013624,-0.06627156,0.03274427,0.04083136,0.06077207,0.0736231,-4.4930093e-08,0.048131965,-0.090433925,-0.039721154,0.019322772,0.009083021,0.06255404,-0.024030972,-0.031172283,0.029389238,-0.059521113,0.007730502,0.040521286,-0.013074528,-0.021915397,0.036646653,0.04644287,-0.071420416,-0.08460988,-0.056330692,-0.0048933686,-0.07655009,0.008254669,-0.04264358,0.044078235,0.012843786,-0.13577618,0.050906412,0.012198,-0.08301817,-0.10189864,0.029051041,-0.037369784,-0.04422454,-0.069010705,0.028617976,0.012695168,-0.08118362,-0.011598959,0.120218664,0.05753393,-0.012868491,0.042327356,-0.07645749,-0.023055019,0.032216668,0.07183796,-0.07552914,0.055487894,-0.1054328,-0.07155963,0.023844536,0.0008086702,-0.029951168,-0.011674625,-0.08033412,0.050082963,0.0464933,-0.0634978,0.023985373,0.0014128787,-0.012135401,-0.0006856182,0.084549844,-0.0083485 +2.4.2.52,"ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (gamma-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase [4].",384,1.0,-0.0630692,-0.017340219,-0.042680867,-0.072865106,-0.014850127,0.009019583,-0.018757988,-0.00025698665,0.033596575,0.05868642,0.09377201,-0.05948633,-0.0899026,0.027409982,0.03218632,-0.035217267,0.014601387,0.0446112,0.008094584,-0.063995436,0.06558006,0.042931624,-0.08874025,0.01906626,0.038370293,-0.008987295,0.041705605,-0.0124603445,-0.061899673,-0.08455305,-0.108375505,-0.08330152,-0.019277377,-0.03442352,0.013596787,0.10376422,-0.1127842,-0.10623976,0.058732048,-0.03572616,0.08099065,0.007868347,-0.0077874484,0.018053025,-0.06304317,-0.0286215,-0.0010354806,0.04384836,0.056993734,-0.06430046,0.021270778,-0.02512257,0.00310897,0.006729672,-0.056805573,0.030375121,-0.046468474,0.0023937398,-0.032349974,-0.0047910823,-0.0485299,0.04581708,0.0008286018,0.016224604,-0.02123395,-0.05896014,0.069566935,-0.02155602,0.005844543,0.02419079,-0.047873504,-0.036066197,-0.0025582402,0.010436811,0.037276335,0.05618765,-0.005227813,0.039202493,0.014994427,-0.0014578109,0.06135722,0.035397638,0.06446533,-0.018923657,0.021126641,-0.062822066,-0.0108193355,0.05856632,0.021627977,-0.05023841,0.046266615,0.0077823265,0.0006802145,0.0014945812,-0.036954664,0.09485898,0.008960961,0.019942446,0.0010844413,-0.025080254,0.044987604,0.13202414,0.024321182,-0.07094691,-0.005879429,0.048390526,-0.034278814,0.0881423,0.012497465,0.06616883,-0.034902442,-0.010299839,0.02961673,-0.05983214,0.024576232,0.10434323,-0.096351534,-0.030140275,0.010207526,0.004183889,-0.001762021,-0.08206216,-0.011319984,0.061551567,-0.037110638,0.053357843,-0.111493774,2.696382e-33,0.04368755,0.030058855,0.046593413,0.036326174,-0.0021319094,-0.027770039,-0.08713031,0.010045992,-0.038006615,-0.06694563,-0.05651004,-0.034422725,0.07264331,-0.035751346,-0.015239206,-0.031125613,-0.030797303,0.026625691,0.12024833,0.041172843,-0.014101988,0.07237973,-0.0015260963,0.002689379,0.019989643,0.121576525,-0.071415134,-0.062940076,0.0012255451,0.024709582,-0.023135597,-0.053544637,-0.074950494,0.02909651,-0.027076662,-0.07174467,-0.08819194,-0.04985951,0.028553491,0.044688087,0.04924346,0.0151584875,-0.0049161906,-0.016557328,0.07767787,-0.03548844,0.019926306,0.02836327,-0.01000858,0.07280478,0.04531871,-0.0844484,0.03887294,-0.012553037,-0.102549054,-0.004600438,-0.025785144,0.012092677,0.08207628,0.018004118,0.068040155,0.12272689,-0.012464346,-0.021441137,-0.004153057,0.04652925,-0.12587115,-0.10815354,-0.018598566,0.082291715,-0.054803338,-0.06777951,0.03627923,0.027177608,0.03529421,-0.07014577,0.0041761985,0.04495261,-0.022779314,0.096119516,0.020599836,0.0033186781,0.003414934,-0.006425638,0.019852037,-0.038978107,0.0035844925,0.015097189,0.012160907,0.045983143,0.0900973,0.011171615,-0.009663096,0.0571865,0.028388424,-4.4306748e-33,0.17644449,-0.10603055,0.05804249,-0.09166203,-0.09299518,0.030420076,0.026711991,-0.05835871,0.023435382,-0.06405309,0.046108235,0.007545091,-0.0055843014,-0.0923355,-0.0004558835,-0.029154414,-0.043030523,0.07155222,-0.0045335423,0.030671878,0.061840024,0.060765292,0.049774375,0.015710875,0.048223462,-0.07852785,0.07168285,0.035214435,0.05469158,0.0104824435,-0.009676886,-0.0024845134,-0.04534362,0.040090226,-0.08549134,0.008581832,-0.049088035,0.04559375,0.015494084,0.06377151,0.054262105,0.090505965,0.07171074,-0.039275605,0.047967006,0.09742447,-0.022689173,-0.021742994,-0.027016092,-0.055468813,0.04179808,-0.025649387,-0.07937326,0.014405788,0.009485027,0.07636105,-0.015996441,-0.020171965,0.0077648945,-0.047697585,-0.08669686,-0.02448773,0.052691694,-0.03423655,0.050743394,0.10361234,-0.0306631,0.017864646,-0.01526127,0.007920052,0.0027397436,0.031748835,-0.010969965,-0.029311413,0.060262576,-0.0071953023,-0.0890686,-0.0022744199,-0.026837619,-0.077653624,-0.03504077,0.032542318,-0.029767213,-0.04580029,0.028896187,-0.044542145,0.029887332,0.11492552,0.006528438,0.00020354218,0.0011260844,-0.012647049,0.046272993,0.06495356,0.0808809,-5.4720967e-08,-0.019022785,0.0225883,0.02451146,-0.03139779,0.0118135465,0.07839506,-0.0036309154,-0.019407077,0.07327362,-0.025534676,-0.02648347,0.031995703,0.03180018,0.024859246,0.010047456,0.07934763,-0.049080204,0.049053684,0.009208276,-0.026302721,-0.047015265,-0.049350943,-0.04680337,0.1149498,0.013200112,0.0032155898,0.058770034,-0.0156929,0.0139330365,-0.08591689,-0.043357447,0.010194627,-0.028440427,-0.001302598,0.016079994,-0.07182702,-0.06469166,-0.04019792,-0.061285384,0.0323916,-0.022377264,-0.029019812,-0.04117491,0.013105557,0.049716968,0.016500315,0.05163694,0.0052711223,-0.07713337,-0.033240538,0.07080573,-0.012901355,-0.045249876,-0.0886824,-0.0580198,-0.06807114,-0.03961579,-0.09482216,-0.039475136,-0.039270423,0.025790015,-0.02071297,0.10787967,-0.040424522 +2.4.2.53,The enzyme shows no activity with UDP-4-amino-4-deoxy-beta-L-arabinose.,384,1.0,-0.0025172587,-0.06027553,-0.037952464,-0.041016556,0.022313248,0.028418578,-0.07686257,-0.012067218,0.008191889,0.0046456023,0.07685267,-0.036792822,-0.02868575,0.049185313,-0.054032058,0.06568835,0.018813083,-0.062484343,0.013230796,-0.051949363,0.00041062234,-0.0030937763,-0.0033817645,-0.014782505,0.10419239,0.016826628,0.06896883,-0.056475908,-0.048195787,-0.06619291,-0.0051576025,-0.042628225,0.015595642,-0.030962743,0.09414477,0.11266897,0.0025782147,-0.0522146,0.05087876,0.00089364755,0.09867356,-0.009568298,-0.01859422,0.0061628297,-0.011496128,-0.018921876,0.008219306,-0.03250562,0.07330337,0.015347172,-0.026972622,-0.07235905,0.00856624,-0.010588573,-0.05410404,-0.049565993,-0.056190867,0.040917598,-0.061599284,0.04327925,0.012305152,0.01752605,0.027363552,0.006579352,0.014671839,0.051955204,0.054237846,-0.062373064,-0.0256754,0.004327417,0.002596786,-0.039982814,-0.056677885,0.05118234,-0.047459297,-0.029911876,-0.028357806,-0.08082367,0.025704794,-0.0048481943,-0.016631149,-0.037621584,0.022346478,0.039436277,0.019023543,0.021235395,0.009507051,-0.009129312,-0.011478202,0.0261838,0.0009630833,0.052653726,-0.08745643,-0.021231368,-0.0005501771,-0.009718442,-0.035575375,0.042856194,-0.08294796,-0.008129978,-0.03975982,0.05941359,-0.05855055,-0.07793126,-0.03417766,0.05012963,0.010439631,-0.018364774,-0.051363043,-0.03210677,-0.005239843,0.0054586264,0.10233255,0.05302678,-0.052956518,0.039525114,0.0060936026,-0.1087405,-0.08784027,0.03162058,0.031174105,-0.03490703,0.13866182,0.041669477,-0.07998878,0.087766126,-0.07280249,-2.6626214e-33,0.047368243,-0.029496973,0.058417875,-0.009656154,0.028533584,0.0271888,-0.023323359,0.05435645,-0.019955572,-0.009362252,-0.061194886,-0.04917151,0.08387558,0.025222108,0.018281257,0.04251043,0.10837707,-0.052158117,0.0544745,0.01869582,0.013432009,0.0064528543,-0.038987298,0.019247934,0.009668801,0.05130517,0.012014481,0.010519607,0.063040294,0.012290913,-0.114407316,-0.043701835,-0.09802037,-0.03123183,0.0058106007,-0.01375103,-0.06233523,-0.028030919,-0.036826458,0.0041565644,-0.02094524,-0.03636457,0.0082709985,-0.07872513,0.06389076,0.011606997,-0.015582839,0.027536618,-0.009836163,0.06893915,0.064431235,0.0056586466,0.05067736,-0.06031432,-0.007065754,0.027676517,-0.044534408,0.009028796,-0.057864565,0.04177834,0.034911882,0.06704203,-0.060205594,-0.023682527,-0.012597792,0.053981066,-0.06863477,-0.078009084,-0.02205466,0.018243369,0.030650688,-0.012383024,0.083948776,0.061986376,0.03903844,-0.05360505,-0.036985558,0.009278986,0.05535371,0.011482312,0.03190137,-0.036826517,0.055622175,-0.005360443,-0.03743855,0.009207026,0.051830087,0.069087856,-0.00557386,0.00992603,0.076753646,-0.015033576,-0.10032705,0.02197025,0.024171535,2.8692688e-34,0.059716042,-0.032939784,-0.031087566,-0.07681085,-0.05516665,0.06527808,0.1040151,0.040564444,0.13121966,-0.010134653,0.1777777,-0.062644064,-0.043960627,-0.09027758,0.073746495,0.054060303,-0.102025904,0.011411204,-0.061796736,0.0148588335,-0.022523936,0.13158531,0.0076483204,0.055266697,0.050526496,-0.021449996,0.036444426,0.13541803,0.021565726,0.040985633,0.040782377,0.05750708,-0.07283224,-0.05539198,-0.048340004,0.069883004,-0.032843646,-0.012908296,0.007414521,-0.031131107,0.009322132,0.088931195,-0.035642788,0.07439447,0.011065098,0.086192995,-0.05936214,-0.008088831,-0.016894681,-0.083619304,0.042424187,-0.004615853,0.0030343528,-0.008397907,0.045957852,0.06920074,0.018523442,0.0066096247,-0.027869359,-0.021450339,-0.018731149,-0.06629661,0.035581484,-0.009572014,0.009525289,0.04581955,-0.0033114988,0.023441738,0.064228825,-0.021366945,0.07071608,0.0028000146,-0.030073976,0.028291184,0.011812408,0.11275197,-0.14285387,-0.0427261,-0.0032076929,-0.09286645,-0.04483538,0.018679725,-0.07788,-0.062670015,0.0737042,-0.058811665,-0.006379144,0.06918196,0.016579036,0.0573772,-0.010038071,-0.04233703,-0.06953237,0.08660105,0.049346726,-2.4607413e-08,0.0756782,0.0076059783,0.07896194,-0.08695046,-0.031683657,0.044351522,0.054154888,-0.0038990278,0.016852176,-0.019355038,-0.047771268,0.04328237,-0.113278836,0.051400173,0.00067198253,0.0046743588,-0.028855842,0.025796326,-0.016865855,-0.04440734,-0.0724064,0.02133962,-0.14574689,0.03705984,-0.021429028,-0.06446762,0.06200422,0.0098099625,0.031493824,-0.05123293,0.008345927,0.007769207,0.013903124,-0.07170638,-0.10830501,0.018237656,-0.02249366,0.032524846,-0.03676989,0.07469431,-0.025413493,-0.07135193,-0.056038238,-0.03626359,-0.015589341,0.0069877338,0.036381755,-0.034482986,-0.016878793,0.02384291,0.094399884,0.013881189,-0.07426118,-0.0028749502,-0.023834273,0.0055903047,-0.011616577,-0.06208019,-0.017936647,-0.04246747,-0.007337715,-0.07095476,0.08901327,-0.026087455 +2.4.2.54,"The enzyme is involved in biosynthesis of tetrahydromethanopterin in archaea. It can utilize both 4-hydroxybenzoate and 4-aminobenzoate as substrates, but only the former is known to be produced by methanogenic archaea [4]. The activity is dependent on Mg2+ or Mn2+ [1]. ",384,1.0,2.5197032e-05,-0.04407453,-0.103882976,-0.07683571,0.06441965,-0.013113925,-0.03939831,0.009055752,0.02295377,-0.0010116743,-0.029272133,-0.09275534,0.023406846,-0.0068495907,-0.10873655,0.0348617,-0.039804354,-0.00396521,0.03170536,-0.03604193,0.06480861,0.09675241,-0.008633183,-0.03128561,-0.053427067,0.013871636,0.015638161,-0.06630262,0.008511761,0.024242025,0.011048832,0.020503098,0.023139497,-0.08140921,0.03742,0.13377132,-0.052326504,-0.0155358035,-0.009964641,-0.027444262,0.075624585,-0.030476267,0.078754194,-0.06322391,-0.046197146,-0.045368448,0.0695909,-0.05140143,0.0103014065,-0.0047048246,-0.053684685,-0.0728156,-0.0160674,0.08147452,0.020152308,0.03859313,-0.0031171723,-0.0389165,-0.042492326,-0.032612037,0.045073587,0.024895186,0.018413141,-0.019777542,0.012444653,-0.009903652,0.0051424047,-0.04647833,0.04121855,-0.05901066,-0.035174917,0.006406918,-0.017577069,-0.0106697455,-0.08588751,0.047854222,0.07637582,-0.03980516,0.0316206,-0.028516497,-0.0063062087,-0.014301326,0.06285109,0.04519646,0.06782799,0.004693208,0.012936424,0.021715814,0.06598367,0.027814329,0.07237198,0.038727503,0.06041675,-0.030041581,-0.058875054,0.00036690355,0.008668488,-0.009160645,0.032766964,0.0040620584,-0.040784117,0.035637796,-0.06604969,-0.05863504,-0.050310224,-0.022228863,-0.022670845,0.14945064,0.06159652,0.05282096,0.02586288,-0.054038513,0.091459036,0.07474747,0.016794244,0.08996366,0.031599008,-0.09983549,-0.016808743,0.013992694,-0.0005235876,0.0092909355,0.079977855,0.046437312,-0.0017320715,0.06752306,-0.12623756,2.6268708e-33,0.111778006,-0.01285956,0.0069848415,-0.028060822,0.063482545,0.026284568,-0.084526986,-0.0027790065,0.040049903,-0.052153,-0.10500688,-0.086105146,0.05686958,0.018370328,0.014166311,-0.044315245,-0.033104666,0.011284102,0.066365875,0.055198472,-0.07401074,0.101694725,-0.06451264,0.007886266,0.037332978,0.0825796,0.030342769,-0.07524207,0.008371568,-0.0003774558,0.0117557915,-0.119210154,-0.14405496,-0.032862876,0.1250184,-0.012468008,-0.03220649,0.02826059,-0.073316425,0.0357025,-0.01203666,-0.010033166,-0.012817027,-0.029284002,0.070043534,-0.022654057,0.017496081,0.09597171,0.047446888,0.007872022,0.05269373,0.019061241,0.04653323,-0.008436857,-0.14367124,0.02985215,-0.053853348,0.01496305,0.11968183,0.018382665,-0.058172457,0.013281394,0.010165048,0.09810959,0.0046724374,-0.0032821668,0.03044846,-0.08999581,-0.0014618202,0.048780445,-0.008676436,-0.04202042,0.08231849,0.024739064,0.023026494,-0.0426673,-0.029400364,-0.038106874,0.015431138,-0.013716188,0.018380312,-0.044297833,0.02470114,-0.010446706,-0.049340084,0.03191571,-0.029888913,0.014155303,0.029335568,0.036712732,0.07078597,-0.049860355,-0.104399815,0.00996208,-0.03825865,-3.366613e-33,0.05611828,-0.087947816,0.0349003,-0.110891335,-0.0932527,0.036411643,-0.06648735,-0.014463842,0.0072417515,-0.051207855,0.12677474,-0.012314159,0.012945147,-0.046647865,-0.01658257,-0.058197953,0.005140547,0.047732286,0.025553068,-0.03252956,0.08735233,-0.016833806,-0.047232013,-0.01137166,0.04185957,0.0112734195,0.03148897,0.08239925,0.012078626,0.030856866,-0.032822162,0.036802318,-0.030303873,-0.05117688,-0.07837944,0.06185405,-0.07737705,-0.030658944,0.030438112,0.02547091,0.08434456,0.05521983,0.03383078,0.058529943,-0.014153576,0.020958943,-0.09203776,0.029932076,0.076309025,-0.03267225,0.004729925,-0.06660823,0.017263995,-0.06772949,0.058708593,0.024028452,-0.021694649,-0.0076236785,-0.0027635493,-0.0009035393,0.031323332,-0.05456134,0.06422918,-0.012050773,0.025559459,0.07715357,-0.005504393,0.064372115,-0.0017004795,0.023810932,0.054731246,0.0076229307,0.062588364,0.08560389,0.04017667,-0.042734403,-0.02778443,-0.00790752,0.018145137,-0.093655296,-0.034582917,0.04304048,0.08603764,-0.0888555,-0.043614898,-0.056339633,0.06296155,0.11089044,-0.0050208005,-0.0075576026,-0.019487504,-0.011944737,-0.068642855,0.0058706366,0.028821511,-3.738991e-08,0.031874154,-0.039477795,0.03306103,-0.07589313,-0.06355973,0.027983697,0.070184484,0.015897207,0.025449906,-0.07083037,-0.0017217527,0.0270218,0.006208488,0.023846507,0.0216307,0.06624334,-0.03333776,-0.03889444,-0.051428087,-0.05029016,-0.023627754,-0.045204915,-0.026885685,0.018405866,-0.024370212,-0.020193662,0.0027376593,0.086847626,0.0055141966,-0.08734906,-0.042204652,0.042605482,0.014693749,-0.026542382,-0.05889998,0.04602606,-0.08529089,-0.0625741,-0.039685342,-0.02171394,-0.07290934,-0.040026873,0.0025802657,-0.025520217,-0.003185779,-0.0453891,-0.010630862,0.05946259,0.0072876285,-0.024960864,0.022651346,0.008022284,0.045106243,-0.06628146,-0.017046321,-0.02600773,-0.00037693285,-0.04752827,-0.0545719,-0.028417123,0.07090882,-0.02620869,0.09290887,-0.05914353 +2.5.1.104,"The enzyme is involved in the biosynthesis of spermidine from agmatine in some archaea and bacteria. The enzyme from the Gram-negative bacterium Thermus thermophilus accepts agmatine, spermidine and norspermidine with similar catalytic efficiency. The enzymes from the archaea Pyrococcus furiosus and Thermococcus kodakarensis prefer agmatine, but can utilize cadaverine, putrescine and propane-1,3-diamine with much lower catalytic efficiency. cf. EC 2.5.1.16, spermidine synthase, and EC 2.5.1.23, sym-norspermidine synthase. ",384,1.0,-0.028231299,-0.046399854,-0.10557624,-0.0637411,0.085916534,0.035506975,-0.0794063,0.061250187,0.038870737,0.0405821,0.0032855857,-0.052241754,-0.04158607,0.06251008,0.006325344,-0.012869652,-0.012568517,-0.021074379,0.019134274,-0.008754253,0.08967978,0.03321499,-0.04482974,-0.045556586,0.04200052,-0.023692848,-0.0075746668,-0.005653087,-0.043719705,0.008453603,-0.009309677,-0.03666086,0.11161382,-0.061390534,0.043389633,-0.018609582,-0.06325065,0.049354374,0.04609405,0.008152789,0.0769747,0.0047285147,0.032867428,-0.035377976,-0.06418146,0.030679898,0.09287901,-0.011557936,0.06951161,0.014990595,-0.06483978,-0.016164728,-0.035179522,-0.041174993,0.019704811,-0.0021157782,0.012177407,-0.117058136,-0.06853164,-0.0010353127,0.008876302,0.0064044935,-0.05665724,-0.0424825,0.031830564,-0.06714181,0.06344861,-0.031391893,0.019547708,-0.036823187,-0.037737943,-0.07409619,0.02927451,0.06629984,0.022636443,0.052317504,-0.024601918,0.001981554,0.076467045,-0.04111037,-0.018477488,-0.07434386,-0.055940226,0.051305603,-0.0037068063,0.011449596,0.09920839,0.029957533,0.10102631,-0.009599021,-0.02205341,-0.017996302,0.016087994,-0.06696292,-0.04065681,0.010474408,-0.005020375,0.038438786,0.009264995,-0.05687413,-0.0155897895,0.045207694,-0.058981977,-0.075301886,-0.10401156,0.00041732413,-0.04734504,0.113433786,0.05416375,0.02912784,0.031401776,0.00068035914,0.03028866,0.027608156,-0.047624584,0.053668745,0.009662108,-0.08953907,-0.058534563,0.027500583,-0.027819129,0.020424796,0.053625103,0.14680435,0.0022166388,0.039669484,-0.043828215,3.473281e-33,0.0572478,0.02890153,0.03288181,-0.018007824,0.050137762,0.086562894,-0.06954218,-0.031241035,0.053895775,-0.065446764,-0.06064875,-0.043575346,0.06695838,0.0118475575,-0.072400056,-0.029281603,0.014469385,-0.06810591,0.018294172,0.033462647,0.035079554,0.06922845,-0.005858399,0.04208767,0.06712548,0.021276338,0.021282196,0.008371902,0.061448015,-0.029396899,0.040316112,-0.08730936,-0.10715448,0.007605539,0.07102038,0.017032996,-0.086529896,-0.051689193,-0.04063213,0.05600224,-0.03683203,0.056479562,0.027321143,0.018374337,-0.0150705185,-0.06864645,-0.028709883,0.14859466,0.020034952,0.078116134,0.0058829435,-0.021958888,0.09879916,-0.0005320154,-0.085488,0.006465558,-0.06543763,-0.019962756,-0.0093755955,-0.019013405,0.049361926,-0.0097794365,-0.007967229,0.04238859,-0.0010878113,0.039526343,-0.05976635,0.018703254,0.042725965,0.09048232,-0.056806915,0.044527493,0.00013647684,0.009621941,-0.015214571,-0.021780787,-0.12597583,-0.01229797,-0.0037233005,-0.07081025,-0.004207685,0.03132547,-0.0325524,0.034788225,-0.0775361,-0.006347102,-0.04292816,0.029972125,0.03659936,-0.0077570467,0.034576245,-0.13201621,-0.025962662,0.020985672,0.0145474505,-3.4805616e-33,0.05184058,-0.12664264,0.025380526,-0.0146267535,0.018507136,0.038260873,0.103371546,0.01151771,-0.061418165,-0.048791688,-0.0006907856,0.012536852,0.15106352,-0.07306836,-0.016190404,-0.02461908,0.038219806,0.07046605,0.05408673,-0.011357219,-0.006308683,0.047294356,-0.025636557,-0.02747225,0.051667556,-0.021849368,-0.02654316,0.047859687,0.0041156677,0.022705648,0.05347172,0.11515006,-0.060799863,-0.05420274,-0.00024098966,0.05728568,0.003019771,0.037723806,0.029156778,-0.016623037,-0.0594149,0.02520325,0.012088912,0.08048743,0.008604289,0.07048904,-0.06284375,0.039081413,0.023981983,0.01036287,-0.0060812435,-0.077786826,0.002063883,-0.07328143,0.02068314,-0.019325037,0.008417168,-0.018712752,0.0051451386,0.009980693,-0.061132103,-0.040035523,0.008561657,0.036417946,-0.04067113,0.06486078,-0.07458521,0.12182998,0.040393688,0.0029180283,0.099859655,0.0015716101,0.051405177,0.021979311,-0.0012244235,-0.022477524,0.020663984,-0.008228498,0.064290516,-0.017573709,-0.0059648766,-0.010504637,0.0050981455,0.030126508,-0.07093368,0.03418702,0.12010908,0.086830266,-0.06239017,0.024761103,-0.057752945,-0.03504282,0.030624952,0.0789353,0.08172152,-4.016413e-08,0.05735796,-0.031335596,0.07773436,-0.005598686,-0.0633413,0.052210707,0.006159376,0.024993734,0.016367944,-0.05939168,-0.031804893,0.022241496,0.013083081,0.0013610154,0.048238315,0.032791216,0.016709726,0.016664326,-0.060361784,-0.043908045,-0.04774626,-0.032057144,-0.16479075,0.027039995,-0.011774461,0.0110155055,0.0026231187,-0.032613926,-0.0058822217,-0.07178093,-0.031898268,-0.013018098,-0.028591894,-0.06915187,-0.090944536,0.010560604,-0.010693716,-0.038921796,0.08237521,-0.04672316,0.07212045,-0.026792834,-0.06639407,-0.0054851403,0.02659779,-0.00030325478,0.0091843875,-0.02700208,-0.08358058,0.05244098,0.023443487,0.038948737,0.010987333,-0.011389323,-0.0789809,-0.06287951,-0.038323738,-0.0909395,-0.011755162,0.04232576,0.020406766,0.006680141,0.15002674,-0.007437624 +2.5.1.105,"The enzyme, which has been studied in the archaeon Methanocaldococcus jannaschii, is involved in the biosynthesis of tetrahydromethanopterin.",384,1.0,-0.06641193,0.015567257,-0.1542831,-0.029649708,0.049230486,0.0056620026,-0.12519212,0.024167627,0.02939536,-0.0047213794,-0.05688261,-0.09906391,-0.07224042,0.023323074,-0.104081385,0.032289594,-0.11765548,0.018625483,-0.0018433166,-0.033983003,0.04249366,0.082521275,-0.007358779,-0.03308174,-0.007644273,-0.04862594,0.0027327582,-0.025586737,0.008492358,0.03658894,-0.018215548,0.00961939,-0.011225558,-0.079012394,0.07988578,0.09854311,-0.0357175,-0.064450465,0.06519681,0.042610493,0.0779209,-0.0155826,0.021244705,-0.039312847,-0.02346585,-0.017545644,-0.014519904,0.01019623,0.040071983,-0.026542744,-0.08752216,-0.09367245,-0.026457049,0.025498323,0.05554782,0.03140727,0.032382466,-0.053781386,-0.005522068,-0.019635215,0.07129926,0.029699933,0.00050359813,0.003214438,0.0032098687,-0.06657018,0.01899321,-0.06646043,0.058266625,-0.05832711,-0.05126626,0.014358682,-0.019139037,0.060830373,-0.043987628,0.036174446,0.0347085,0.02249628,0.004369387,-0.033830326,0.033469185,-0.026861606,0.012972603,0.03854609,0.038326915,-0.009721298,-0.02427278,-0.0021881512,0.051316272,0.032523163,0.016644139,-0.029047916,0.0018649143,-0.08585137,-0.032177452,-0.04511824,0.033398926,-0.050743878,-0.017566543,-0.011680787,-0.04462864,0.022617664,-0.025112359,-0.045488972,-0.039840728,-0.012582055,-0.054507237,0.07187847,0.03929105,0.03972918,0.06377382,-0.025023796,0.12515177,0.029867293,0.003891374,0.07516917,-0.030064054,-0.07462595,-0.0020916634,0.055842083,-7.49509e-05,-0.033967927,0.07879961,0.04697403,0.01098093,0.062342677,-0.10418127,9.441579e-34,0.08496791,-0.012088405,-0.04265381,-0.06971337,0.07320566,-0.034727376,-0.07890699,0.03614478,0.032766342,-0.068385534,-0.08578469,-0.0853129,0.055459734,0.0002893933,0.0053835567,0.014547391,0.020646356,-0.024562014,-0.007733041,-0.0025180664,-0.037729155,0.079073355,-0.036481336,0.011472342,0.04155504,0.09646727,0.0028038083,-0.010686935,0.00030221677,0.0047015273,0.072903454,-0.08610761,-0.093524426,0.0358425,0.1133005,0.010548251,-0.009339827,-0.03037192,-0.031718418,0.039604202,0.014208552,-0.025666472,0.023609063,-0.03556642,0.070454545,0.016012808,0.011992316,0.06895077,0.111776106,-0.025619203,0.042683046,-0.00057460536,0.04004674,-0.022600146,-0.11761958,0.0040587103,-0.051629428,-0.039253864,0.10188439,0.051794276,-0.08991999,0.00075529487,0.005220408,0.09465564,-0.0227378,0.00072326924,-0.04638016,-0.11818599,0.012757711,0.06371615,-0.040960096,0.0108176,0.03397086,0.007416916,0.029374646,-0.026916066,0.019380707,0.04318974,-0.022319414,-0.05485935,0.07287497,0.0039421055,0.03010237,-0.009879519,-0.046986483,0.0039319615,-0.010740019,0.018312633,-0.00518249,0.050807104,0.05493267,-0.07138746,-0.118315086,0.022588104,0.01117575,-2.7049278e-33,0.07758701,-0.11680649,0.017991234,-0.10209253,-0.06409727,0.09936419,-0.07762105,0.020150458,-0.00053399254,-0.09544917,0.101662986,0.0077482276,0.01916997,-0.0150225675,-0.0010573963,-0.051448166,0.031191984,0.078495406,0.021719974,-0.023581462,0.05711981,0.03948811,-0.05429842,-0.09223721,0.06570163,-0.032463852,-0.026690908,0.06534013,-0.034794003,0.029570976,-0.014747279,0.005149579,-0.050750762,-0.072057895,-0.06982406,0.047124762,-0.044832233,-0.010732133,0.079175614,0.03401235,0.0970634,0.07168534,0.01603166,0.040332355,0.028311025,0.036233336,-0.1024662,-0.0039106198,0.030755073,-0.046660017,0.03929827,-0.04421636,0.090353794,-0.03622622,0.037647005,0.06472313,0.033234734,-0.011575543,-0.0012275856,0.018087903,0.016784627,-0.05903711,0.09173027,0.017672403,0.029998971,0.0661113,-0.012558216,0.075077966,0.06814949,-0.008242425,0.049701724,0.04006416,0.029808644,0.07615902,-0.0026644731,-0.054200023,-0.08857242,0.015295086,0.030825412,-0.031189388,-0.0744531,-0.0067769517,0.09289675,-0.020863878,-0.047920663,-0.0030836924,0.0696757,0.09165129,0.023321915,-0.027440589,0.003675777,-0.0067237536,-0.082492456,-0.008638733,0.07940386,-3.0749383e-08,0.068875924,-0.057390552,0.005514682,-0.05627384,-0.024177762,0.0071916794,0.06307208,0.015392543,-0.02310704,-0.009401534,-0.019650834,0.06680316,-0.032406066,-0.021654196,0.0077690496,0.046986874,-0.059259586,0.0006381944,-0.023236964,0.028116966,-0.0016297563,-0.024851251,-0.036135323,0.022673042,-0.007566239,-0.048904285,0.027541777,0.07697907,-0.030862868,-0.061423697,-0.057766818,0.047999922,0.00017023424,-0.032528,-0.09371786,-0.010888969,-0.07161584,-0.07364018,-0.032611538,-0.031272456,0.045274448,0.0062476234,-0.01324487,-0.0026258258,-0.010773642,-0.037688483,0.052096628,0.0151367225,0.0022596167,-0.071930364,0.038277082,0.026184507,0.00844056,-0.025515333,-0.070021525,-0.054860678,-0.011889339,-0.039717276,-0.1023403,0.0034987426,0.08860031,0.02707353,0.14340717,-0.0066773547 +2.5.1.106,"The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2 [1], but also at C-3 [2]. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen. ",384,0.99999994,0.030717637,-0.014206162,-0.098024584,0.010310135,-3.6591286e-05,0.09075348,-0.06549795,0.017192025,0.069874756,0.016350452,0.10173585,-0.057261597,-0.03759727,0.08760019,-0.076752275,0.053699937,-0.0040760334,0.030223744,0.047187455,-0.051216874,-0.003083276,0.086838454,0.044264197,-0.0034763769,0.0067204535,-0.04815593,-0.042448595,-0.0009995158,0.010965331,-0.04726027,-0.06886796,0.024145031,-0.031459834,0.006588445,0.045469962,0.06913294,-0.13197899,0.06647315,0.13795044,0.055022985,-0.06762112,-0.08231271,-0.07626789,-0.015477454,-0.082073025,0.016394213,0.010613579,0.0629063,0.07365746,-0.014371798,-0.054981995,-0.0086683575,0.039156534,0.043583017,0.10295953,0.038024314,-0.035848796,0.032439336,0.0036728573,0.048739992,-0.0150953615,0.028092695,-0.053855162,-0.024291156,-0.01699745,0.005794164,-0.02364241,-0.042217128,0.026578207,-0.001371798,-0.00882462,-0.06949346,0.045614246,0.010833439,0.040913742,0.1317159,-0.018310165,-0.03644447,-0.07230407,-0.10882965,0.09011983,0.04464436,0.05229241,0.04921288,-0.012837113,-0.02089305,-0.012505611,0.048662752,0.02513743,-0.03247738,0.08466633,-0.006889349,-0.0012000945,-0.023730988,-0.025154768,0.053514596,0.054922786,0.0024912779,0.035138458,-0.036477953,0.087863006,-0.065973885,-0.07513002,-0.04450154,0.02141316,-0.047795814,0.0061934865,-0.008846667,0.045404073,-0.007505491,-0.011177821,-0.014577232,0.06948469,-0.069154814,-0.047044963,0.014974711,-0.00695854,-0.01798041,-0.012144661,-0.041096665,0.0119881295,0.039739788,0.030439379,0.0623398,-0.014216512,0.020438496,-0.06996127,5.314658e-33,0.13511124,0.052666824,-0.011455192,0.026716914,-0.041447718,-0.052816924,-0.01871447,-0.031979788,0.0063996944,-0.026770974,-0.10460748,-0.061238874,-0.033692613,0.002369248,-0.042203445,-0.010615977,-0.056021616,-0.066160284,0.049394555,-0.02011493,-0.05680823,-0.028295722,-0.08921185,-0.04440808,-0.03199854,0.062265303,0.020514384,0.03578803,0.039860442,-0.03343667,-0.037826937,-0.020131214,-0.11061672,0.0066880453,0.04170282,0.004153849,0.02288929,0.005671079,-0.09363766,0.030652232,0.014875041,0.11775738,-0.010726282,-0.04621628,0.098890886,-0.019156279,-0.093923084,0.112436846,0.0778478,0.065534085,0.080135554,-0.0020784969,0.063349485,0.046523076,-0.05869837,-0.0049572634,0.011381863,-0.024896119,0.015242924,0.06826556,-0.11493002,-0.041253332,-0.043231603,0.012545169,-0.033700366,-0.005069811,-0.067435786,-0.096328095,-0.009012896,0.057464607,-0.0806804,-0.021226788,0.01693781,-0.0034809164,0.00037746015,0.0119819995,-0.04180059,-0.03456234,0.005076132,-0.003084406,0.02053786,-0.056760166,0.0037285774,-0.00074464997,-0.01866789,-0.07798337,-0.022332845,-0.088278644,0.006035376,0.03574852,-0.024322458,-0.025190333,-0.03870698,0.09759049,0.051453527,-6.393321e-33,0.098836854,-0.109903395,0.035614792,-0.034536097,-0.06888158,0.057057783,0.0021743295,-0.041287884,-0.018490888,-0.011610139,0.08108809,-0.045408353,0.120544136,0.032370582,-0.05503314,-0.041039128,-0.015147098,0.16281146,0.04320795,0.07020582,-0.06031141,0.026142618,-0.019830422,0.01519001,0.084056914,0.07780198,0.010726688,0.03622124,-0.040103104,0.06646244,0.035938498,0.005873932,-0.08985233,-0.009928242,0.036391918,0.07054289,-0.04699636,0.00017962133,0.027921923,0.062583715,0.017229842,0.003240275,0.0503319,0.022068996,0.007895828,0.023883518,-0.05300629,0.053925168,0.025945233,-0.08764845,-0.018733464,-0.015983678,-0.017699473,-0.028072538,0.027324822,-0.021121187,0.03910943,-0.040333018,0.06797499,-0.03353806,-0.07648019,-0.031332824,0.021915648,-0.06514535,0.015176743,0.02804882,-0.0036259028,0.008436689,0.1086082,-0.042233557,0.0412564,-0.018330138,0.02976895,0.028792577,-0.06472378,-0.04478934,0.004999681,-0.03804555,0.06474053,0.03966037,0.014306114,0.04840698,0.020081677,-0.011733151,-0.03346595,-0.026832616,0.035992704,0.033880975,-0.023853349,0.009125993,-3.5126763e-05,0.043032564,0.032366812,0.056421816,0.061906546,-3.9639044e-08,0.05703551,-0.023197785,0.02744633,-0.037178542,-0.013340637,-0.03635237,0.02502938,-0.002176019,-0.0015036679,-0.084387794,-0.05029946,0.08129989,-0.0055317422,0.04356841,0.047427736,-0.030682791,-0.01622723,0.035442013,-0.02065551,-0.015404145,-0.07590536,-0.016904889,-0.034977093,-0.038873557,0.005070724,-0.066641204,0.06358147,0.0115930205,0.05349535,-0.0040115393,-0.020964,-0.0016001601,-0.006656369,-0.07415571,-0.027857704,0.032593682,-0.05260976,0.0192659,-0.024380596,-0.02867307,-0.021233909,-0.08090069,-0.089323305,-0.026721776,-0.086511604,-0.10031388,-0.020655086,0.074446514,0.032961927,-0.03767472,-0.0032093986,-0.0056584617,0.021096192,-0.021288585,-0.0817215,-0.031055769,0.014187694,0.008953313,-0.022962952,-0.12925881,-0.06036759,0.030323645,0.15156521,-0.00018255875 +2.5.1.107,"Found in a number of fungi. Catalyses the last step in the biosynthetic pathway of the indole alkaloid fumitremorgin A. The enzyme from the fungus Neosartorya fischeri is also active with fumitremorgin B and 12alpha,13alpha-dihydroxyfumitremorgin C.",384,1.0,0.055789817,0.0012231428,-0.11491226,-0.047464617,0.0024707732,0.062183414,-0.06847623,-0.018785646,0.06110408,0.0010595708,0.056521587,-0.074483626,-0.0706078,0.020873727,-0.07729411,0.06636834,-0.07273216,0.021173703,-0.014041081,-0.043758985,-0.008693592,0.01884728,0.09319063,-0.038336117,0.007559289,0.00228634,-0.017968077,-0.022466738,-0.018277308,-0.061551582,-0.0032799684,0.03603732,-0.034430787,-0.0085852,0.036606383,0.06529738,-0.08590801,-0.007838951,0.121479966,0.020264247,-0.09902216,-0.06863422,-0.020448927,-0.018964196,-0.058838435,0.0082387,-0.038956814,0.024549931,0.0689653,-0.03552211,-0.012803059,-0.01450574,0.0011657769,0.09328621,0.11194703,-0.006280183,0.030337872,-0.010926312,-0.034514416,0.062191494,0.058786735,0.06308806,-0.026519518,-0.027447034,-0.072663285,-0.059738316,0.0049612164,-0.05166814,-0.008116316,-0.010886865,-0.004157149,-0.07746743,0.0076997983,-0.05771125,0.027100593,0.092451915,-0.01674034,-0.018530035,-0.042789467,-0.06729777,0.05761086,0.026945667,0.075226225,0.054734208,-0.013293699,-0.04279967,-0.0058727185,-0.016499672,0.028363941,0.066780865,0.064510405,0.051926535,0.005936327,-0.073062144,-0.0068103652,0.0006575182,0.050472915,0.07134354,0.053895075,-0.019792585,-0.00867745,-0.011497233,-0.0709661,-0.07773583,-0.07117573,0.002538744,-0.045529626,0.042560216,0.077618055,-0.06991723,-0.024356904,-0.0040901983,0.09829224,-0.0139531065,-0.029517509,0.053631287,0.028913144,-0.024624871,-0.011280536,0.020481108,-0.009689967,0.026096793,0.017498821,0.09343791,-0.047692858,-0.011995506,-0.061374478,4.283903e-33,0.13232756,0.05333454,-0.040471524,-0.015505578,0.04285128,-0.040231977,-0.028547509,-0.00910338,-0.04490558,-0.019829225,-0.076130964,-0.046044335,-0.052804545,0.03314142,-0.029576335,-0.028123097,-0.013802373,-0.04650886,0.0073214322,-0.037628416,0.01749881,0.018142352,-0.062347922,-0.06654337,-0.036957294,0.119591296,0.023275102,0.08131666,-0.0083959885,-0.0239309,-0.010957756,-0.064173765,-0.12763968,0.0219055,-0.007534334,-0.0025608963,0.013416209,-0.002121272,-0.056817625,-0.036852818,0.0592642,0.08212073,-0.008424886,-0.027594212,0.06535726,0.032124277,-0.042222843,0.10730373,0.12651156,0.027604349,0.018959532,-0.004888806,0.0962653,0.022074407,-0.037389114,0.02637917,-0.028253935,-0.006350742,0.015145841,0.08474844,-0.037312165,-0.0025996016,-0.0275855,0.063901745,0.016140362,0.010645049,-0.02741571,-0.092479825,0.028944787,0.084870994,-0.063234895,0.056233436,0.0032405248,0.03369915,0.01644808,-0.022626579,-0.028389748,-0.07385488,-0.06600751,-0.0077951243,-0.0069614933,-0.0064918296,-0.016141668,0.014311539,-0.023088347,-0.015203954,-0.09935466,-0.0790217,-0.019375062,0.07915195,-0.0792139,-0.06135919,-0.050908968,0.09088356,0.045549475,-6.0463385e-33,0.07681334,-0.08069651,-0.009010959,-0.08166903,-0.06192383,0.09773062,-0.025841106,0.01729717,0.009875381,0.041741736,0.036018312,0.007340636,0.12018988,0.035310186,-0.06738713,-0.047138106,0.06675033,0.09540835,-0.014812786,0.036053658,-0.051480494,0.08267899,-0.064496994,0.023056792,0.043774053,0.05608718,0.009231115,0.06335736,-0.107898474,0.039439294,0.06268812,0.010069792,-0.055616405,-0.041885287,-0.028351424,0.03859604,-0.012443119,-0.08120902,0.02841499,0.077537455,0.004343479,0.06648457,0.019904021,0.05810798,0.056284714,0.02159887,-0.075334094,0.06684021,0.02495401,-0.058064155,0.007582593,-0.0025740457,0.032908913,-0.06756351,0.034145936,0.019034615,0.027227042,-0.056246284,0.080276966,-0.019886004,-0.035905935,-0.0197671,0.035612043,-0.0020284725,-0.025377957,0.078904994,0.010146466,0.019900234,0.112438,-0.035439495,0.07904073,0.035112455,-0.010202056,0.12649633,-0.011325272,-0.017606502,0.006246612,-0.03710743,0.007634006,0.035599694,0.024288468,0.008609621,0.05595285,-0.11175459,0.0069880467,-0.012473295,0.02003201,0.050007407,-0.05997296,-0.006844203,0.021233229,0.019256257,-0.07295476,0.029873958,-0.005368859,-3.400357e-08,0.056496736,-0.042916197,0.02617546,-0.07217017,-0.0058386913,0.033002228,0.052870736,0.029321348,-0.034154974,-0.123247944,-0.04475952,0.08569111,-0.005835421,0.07397487,0.019692754,-0.037833527,0.01679121,-0.009162713,-0.040571935,-0.023629496,-0.019025264,0.018916298,-0.02906461,0.007377249,-0.021601574,-0.0573524,0.013964002,0.011355553,0.020228116,0.02350863,0.021764182,0.06942767,-0.027284164,-0.06397635,-0.048737105,0.042973682,-0.014710954,-0.040902074,-0.024830963,0.0060020215,0.0072986563,-0.033705086,-0.08153889,-0.04453922,-0.08637844,-0.048896924,-0.019023536,-0.0025936768,0.003542729,-0.011394055,0.07293307,-0.023920448,0.002005655,0.015620652,-0.12112098,-0.08337024,-0.009553511,-0.030520167,-0.0185464,-0.118422754,-0.0024871852,-0.040725477,0.13323803,-0.041385796 +2.7.1.178,"The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with similar catalytic efficiency. cf. EC 2.7.1.45, 2-dehydro-3-deoxygluconokinase and EC 2.7.1.58, 2-dehydro-3-deoxygalactonokinase. 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+2.7.1.179,The enzyme from the bacterium Amycolatopsis mediterranei is specific for kanosamine.,384,0.99999994,0.0031536494,-0.040926497,-0.058690593,-0.0057193465,0.03675896,0.016557192,0.019737454,0.019907955,-0.0022590205,0.052949388,-0.016643463,-0.07773867,-0.029585306,0.031227859,-0.09463133,0.036199983,-0.05570474,-0.050529025,0.05331653,0.04826107,0.07534505,0.018060032,0.0049852445,-0.014507676,0.0073172036,0.0070130187,0.01351821,-0.039292295,-0.07022733,-0.026808629,-0.052312847,-0.04692078,0.07496793,0.008542575,0.062338483,0.0407623,-0.049161755,-0.027785156,0.020924602,0.0036258695,0.017702064,0.0069098654,-0.0066790986,0.024330791,-0.015726862,-0.0383822,0.024505163,-0.023263104,0.05355341,-0.036006834,-0.070667535,-0.08081909,-0.054663286,0.009940052,0.0060673743,0.025702639,-0.011547043,-0.009205704,-0.00493822,0.016363349,0.005662622,0.071288876,0.07073737,-0.059448767,0.016614066,-0.085306585,0.01136851,-0.010474157,0.046863273,0.010390411,0.03301258,-0.023324117,0.00727151,-0.014471624,0.010028924,0.012002647,0.02306759,-0.0149930725,0.00782991,-0.030080775,-0.047356915,-0.0030956785,0.088750765,0.06257509,0.0079418095,0.002431564,0.09666855,-0.04169896,0.11085284,0.07712625,0.052581545,-0.041534018,-0.04442213,-0.04718839,-0.085394904,-0.0823445,0.05137299,0.01658552,0.08612267,-0.0020476,0.0072513106,-0.032303493,-0.0015310323,-0.15988581,-0.030324247,0.014895343,0.07075514,-0.022170339,0.09916505,-0.025664447,-0.019129094,0.034769714,0.0037215513,0.03762139,-0.021029932,0.052396327,0.0437982,-0.08712676,-0.01734765,0.08662272,0.0045024916,-0.030737884,0.07867642,0.016884048,-0.060519136,0.05867983,-0.13638003,-1.3926096e-34,0.010723277,0.014043108,0.032325856,-0.048529223,0.046893597,-0.07665004,-0.048652753,-0.065493576,-0.10284934,-0.061768238,-0.15057743,-0.059532914,0.00981906,0.079373516,0.02293314,0.05882503,-0.057601847,-0.022389956,0.050998952,0.026843183,0.010103515,0.0033096361,-0.1009088,-0.037014388,-0.009870575,-0.01933953,-0.011256118,0.04006876,0.0721715,0.022916947,0.07419342,-0.070550054,-0.082471766,-0.014028196,0.04019803,0.07925486,0.035529733,0.027769215,-0.035485316,-0.025455523,0.066168815,0.05667011,-0.01971055,0.032299303,0.031594124,-0.04057988,-0.030155921,0.064871095,0.04778204,0.03669883,-0.030484011,-0.061259296,0.10941943,-0.014882697,-0.062083807,0.072678916,0.006646808,-0.032674976,0.09432234,0.03831248,-0.029611532,-0.0019185799,-0.02901815,-0.014677889,0.036372773,0.030029483,0.007692634,-0.032470275,0.0017973178,-0.021339234,-0.09619239,-0.08575998,0.0048739235,-0.0106469495,-0.0448469,-0.028204242,-0.08418947,-0.02607939,-0.023696423,0.016236642,-0.016256157,-0.04510802,0.006973836,-0.059903916,-0.05939367,0.05620544,-0.0031268054,0.020019313,-0.07406249,0.07496034,0.08259192,-0.04709742,-0.010967201,-0.035991233,-0.06572187,-1.4775671e-33,0.051647536,-0.11437673,0.031439237,-0.030227516,-0.014874362,0.043587096,0.017056009,-0.03402096,0.027190631,-0.021130709,0.0753231,-0.022571974,0.030403621,-0.010068287,-0.016268259,0.07641238,-0.037425466,0.047906175,0.04925769,-0.00884508,-0.10820058,0.060849294,-0.07876331,-0.03685996,-0.055910036,0.05223404,-0.031948954,0.088581406,-0.015231006,-0.019159785,-0.03311888,-0.010608604,-0.024245951,-0.027416812,-0.09364054,-0.019611333,-0.051166654,-0.09572808,0.06675411,0.04612855,0.054928303,0.07203601,0.014886471,0.06969038,0.001725189,0.04455668,-0.042552933,0.020582022,0.003505566,-0.03237947,0.04753308,-0.052621454,0.026121277,-0.023453912,0.030007735,0.03857667,-0.01844462,0.03027849,-0.047185365,-0.027496606,0.031008251,-0.040527638,0.04339278,0.03448669,0.039299745,0.08482109,0.021495977,0.060420893,-0.0015736293,-0.10740719,0.038647857,0.08660791,0.04246161,0.083787516,-0.020004347,-0.08095015,-0.06629462,0.032736138,0.027563378,-0.08711495,0.07365313,0.0047405176,0.022197744,-0.101632096,-0.03780264,0.014746525,0.057829224,0.08692985,-0.0066431407,0.009140377,-0.029013865,-0.075026646,-0.04294497,0.08381635,0.055634465,-2.5135302e-08,0.07316767,-0.07734109,0.015086109,-0.055618793,-0.031738482,-0.007639976,0.01966315,0.014730871,0.041275192,-0.008151449,0.0068768086,0.13060144,0.02527226,0.025882585,0.010925139,-0.030459763,0.030023105,0.05143064,-0.032863155,-0.033152863,-0.07456898,0.06377181,-0.07339272,0.03205674,0.074052386,-0.003553504,0.0053392975,0.058516864,-0.07582853,-0.08840662,-0.09033213,0.06782987,-0.06104449,-0.022904122,-0.019544365,0.03227769,-0.0751395,-0.06467238,0.019544885,0.040192276,0.0717153,-0.023091402,-0.02458751,-0.05499165,0.014008714,0.02269651,0.06316309,0.01825382,0.024955709,-0.054156926,0.035197325,0.06578295,0.008214842,-0.0026810132,-0.0856801,0.032700878,-0.031848714,-0.05419458,-0.041909833,-0.062287163,0.041213717,0.018180398,0.16368172,-0.04432217 +2.7.7.85,"Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signalling molecule [1].The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity [2].",384,1.0,-0.08233609,-0.07330471,0.029285623,-0.043158676,-0.001739822,-0.0032790434,0.03283968,0.029964488,0.10422685,0.066004686,-0.0018780875,-0.054683868,0.0078017903,0.043736443,-0.01641272,0.034755602,-0.09243695,-0.02831769,0.0046762885,-0.087313734,0.027647233,0.09797264,-0.008668259,0.030246634,-0.072374,0.07126854,0.06553658,-0.0041755494,-0.025240947,0.015489985,-0.023620212,-0.028895231,0.07596239,-0.00725023,-0.021087533,0.058521423,0.028704401,-0.0028355562,0.05582943,0.038487438,0.029517123,0.00029610327,0.044138435,0.0073877852,-0.032337718,0.012198586,-0.040394384,0.07232191,0.078679614,-0.046517514,0.003246531,-0.02629852,0.032033104,0.01221787,0.0743664,0.037766885,-0.043550104,-0.008094828,0.017709851,-0.025308399,0.077535436,-0.07412021,0.024220904,0.07470861,-0.018821688,-0.068772316,0.02879027,0.00696822,-0.033800695,-0.024760708,-0.041297454,-0.046877682,0.05211735,-0.027243696,0.07432331,-0.010155053,0.010274927,-0.12781882,-0.025187124,-0.06288325,0.0528266,0.06375358,0.12539148,0.07281602,0.004192111,-0.030914925,0.035554595,-0.0069819703,-0.054577246,0.004458674,-0.032847375,-0.06560639,0.027001098,-0.06037198,-0.08203953,0.0055091637,0.046346374,-0.047419757,0.03984209,0.041271478,-0.041939836,0.015835619,-0.08114325,-0.05403365,-0.0032946696,0.050540697,-0.029438468,0.031734742,-0.04591759,0.057412792,-0.0027453282,0.06765158,-0.009942255,-0.05426856,-0.03723936,0.044445556,-0.020996543,-0.04185845,0.06685347,0.027334688,-0.03309332,-0.09050673,-0.004008946,0.08878248,-0.07792656,0.047986813,0.0023322895,2.163867e-34,0.0044970266,-0.006035116,0.07512804,0.015383436,0.029075189,0.030950127,-0.010910861,0.013675706,-0.020222997,-0.089430265,-0.0086005265,-0.07179687,0.065360345,-0.003950528,0.0202474,-0.0012175817,-0.090184495,-0.0020342697,0.02071441,0.010511825,-0.031708375,0.004625496,-0.034680992,-0.015547723,-0.024581458,-0.02479405,0.012086368,-0.02732641,0.093681656,-0.00807288,-0.018004313,-0.004229342,-0.017245574,-0.014778057,0.046378978,0.0449019,-0.079603985,-0.021450901,0.033180512,0.0043745395,-0.010135592,-0.040238407,-0.03739891,-0.06317933,-0.027973,-0.044317372,-0.041716825,0.07931334,-0.030383471,0.05269466,0.11087241,-0.023013221,0.025643725,-0.10043791,-0.06745546,0.059976853,-0.020831808,-0.056354772,0.0022189047,-0.00093712145,0.007585301,0.0032447835,-0.033253018,0.03963256,-0.038863987,0.035701793,-0.023615438,-0.08604873,0.056177173,0.11357343,0.015414417,-0.019415164,0.00023642591,0.055964403,-0.03954846,0.05980885,0.005729097,0.0355489,0.01195815,0.077896796,0.0055099037,-0.06372515,0.02343689,-0.005145691,-0.030048436,-0.002042426,-0.026444774,-0.060594797,0.025452536,0.09827663,0.046975855,-0.10672477,-0.043923542,0.06581256,-0.04338446,-2.5522484e-33,0.046042345,-0.05903561,0.00855723,-0.049293283,-0.03161916,0.014497693,-0.10634558,0.02008126,-0.021317445,-0.011214062,0.08883473,0.10623492,-0.001124809,0.022268208,0.022769801,-0.026091868,0.061067127,0.042125326,-0.098094225,-0.0008434607,0.05219499,-0.03485181,-0.01215851,0.032579232,0.020269055,0.04015699,-0.07692235,0.056320827,0.011031325,0.07713292,-0.06399962,0.07604763,-0.032825816,0.030019807,0.026980748,0.025145859,-0.046636537,-0.072922826,-0.022522336,-0.021018231,-0.046127137,0.09894962,0.035651926,0.11347797,0.007969941,0.12683113,0.043804858,0.08276172,0.017997729,0.0038983072,-0.05185056,-0.050888598,0.02468687,-0.00048325266,-0.024002047,0.07686373,0.038653653,0.0020385985,0.051716514,-0.04220132,-0.04216637,-0.06146806,0.020039331,-0.04714051,-0.011616777,-0.042511933,-0.030247351,0.0095036235,0.008708387,-0.051869888,0.020480754,0.06521845,0.04037817,-0.057215307,-0.13593486,-0.041659594,-0.011892108,-0.06288889,-0.07345747,0.06715797,0.013329123,0.013774358,-0.0071894177,-0.008265483,-0.03214536,-0.012380546,0.08067625,0.08341464,-0.07649614,0.0605895,-0.06496231,0.040244855,-0.06343507,0.07693631,0.03712236,-3.9029896e-08,0.09438054,-0.07007746,0.01514332,-0.10910268,-0.045820404,0.04783857,-0.029524406,-0.015952034,0.037186336,-0.09454025,0.017110983,0.04627275,-0.0006234776,0.08100077,-0.029663498,0.08517568,-0.048118938,-0.10972655,-0.023037136,-0.059267603,-0.092955016,-0.028990956,-0.038619727,0.04556864,-0.07016917,0.016020576,0.071522154,0.040486943,0.0005562983,-0.06808556,0.012762416,0.04074079,-0.06765876,0.0006746757,-0.08006753,0.0065733497,-0.0313882,0.0037225261,-0.061640482,-0.01310276,0.028884126,0.038911827,-0.058448873,0.015930548,-0.07950161,-0.010434559,-0.03666874,0.10238545,-0.039058343,-0.051873233,-0.0022624203,0.010568888,0.0022045975,0.02409834,-0.08829107,0.009908462,-0.01177428,-0.092684105,-0.0010843395,-0.03955501,-0.06896204,0.013749991,0.18386981,0.0051510395 +2.8.3.18,"In some bacteria the enzyme catalyses the conversion of acetate to acetyl-CoA as part of a modified tricarboxylic acid (TCA) cycle [3,5,6]. In other organisms it converts acetyl-CoA to acetate during fermentation [1,2,4,7]. In some organisms the enzyme also catalyses the activity of EC 2.8.3.27, propanoyl-CoA:succinate CoA transferase.",384,1.0,-0.104810424,-0.03373996,-0.096033745,0.0072912807,0.0544972,0.08284684,-0.11951273,0.0025638153,0.031303927,-0.00037889334,0.028229719,-0.115696155,-0.06464141,-0.02990251,-0.044296563,-0.017049767,-0.022589894,-0.012878451,0.035586387,-0.09924118,0.053497307,0.0121653695,-0.07797908,-0.015551758,0.024217738,0.04451958,0.013875587,-0.04592791,-0.05034575,-0.07725339,-0.055756677,-0.01244091,0.0060978075,-0.0063133556,0.046836305,0.05489842,-0.060657285,-0.043884333,0.13542935,0.06435811,0.04694396,-0.030169992,-0.03589148,-0.057908565,-0.0037208954,-0.03834848,0.021572443,-0.011806397,0.037257984,-0.06176811,-0.0478876,0.016258955,-0.056732073,0.027564006,-0.039989363,0.007323,0.02191059,-0.057539556,0.015116217,0.032092534,0.032203358,0.0024066358,-0.011675254,0.03872218,0.015904866,-0.105482474,0.024702404,0.0046554003,0.01343299,-0.025311688,-0.107686505,-0.021806506,-0.029839093,0.065801896,0.061628915,-0.02477,-0.00064482,-0.05317613,0.040009327,0.0020373662,-0.012980818,0.009309337,-0.07359564,-0.0036903943,0.019469988,-0.004073441,-0.011870559,-0.008679036,0.019244958,0.04441894,0.03682128,0.019389616,0.06050738,-0.07246036,-0.067080475,0.048329033,0.026436044,0.00760573,0.10468464,-0.041337952,-0.010213499,0.116089776,-0.057247244,-0.12023188,-0.01160477,0.009149068,0.02607857,0.10752422,0.07749932,0.06327363,-0.022703117,-0.007296246,0.03860942,-0.040883407,-0.020784218,0.112409815,-0.030971548,-0.061112374,-0.024338756,0.055164635,0.036456935,-0.082334496,0.0638047,0.121030316,0.043295912,0.04619727,-0.040214214,1.9813347e-33,0.08832675,-0.0039827772,0.0359534,-0.020955004,0.041649517,-0.035549447,-0.068110906,-0.018648315,-0.014885743,-0.008388147,-0.0047206325,-0.016287263,0.025406465,0.0268162,0.0019579974,-0.013780289,-0.06572346,-0.03593869,0.053880036,0.030744132,-0.03714079,-0.00045569503,0.008427078,0.07155588,0.01661291,0.0060721785,-0.03028824,0.07756636,0.036093727,0.010304571,0.007414756,-0.03304913,-0.049773887,0.0074353437,0.021062177,-0.061880697,0.0032043627,-0.013654156,-0.003957665,0.1245735,0.08276017,0.036319006,0.02192403,0.023666285,-0.010589424,-0.05351872,-0.053395044,0.10370305,0.054018546,0.028168704,0.019682955,-0.025109092,0.14803682,-0.039490677,0.017627181,0.049679246,-0.051341936,0.004782547,0.05621538,0.024111183,0.02100568,0.07966161,-0.025701208,0.023935776,-0.08213996,0.028681822,-0.08093457,-0.03031368,0.05173307,0.04313325,-0.08144973,-0.03365179,-0.00889113,0.052813973,0.09218001,-0.038085826,-0.058963567,0.008225633,0.031996813,-0.026193282,-0.011269329,0.027308352,0.047353823,-0.0040988633,-0.0053275255,-0.037355326,-0.0595245,-0.040583372,0.017535461,0.019688364,0.047483448,-0.022049483,0.028607553,0.05084699,0.02710169,-3.262243e-33,0.11957124,-0.09679809,0.0038953347,-0.11232697,-0.07913473,0.030143602,0.0023318874,-0.04172683,-0.007401356,0.025663005,0.09786331,0.020941885,0.061003458,-0.016660161,0.018525353,-0.042263612,0.06000923,0.02816148,-0.060428932,-0.02046495,0.028419629,0.04116486,0.046866808,-0.03329897,0.079016715,-0.019785479,-0.075395115,0.07230191,0.03456004,0.03465169,0.012030776,-0.043309633,-0.00977062,0.0342172,-0.08452842,0.03955713,0.0007353869,0.04406668,-0.0052788635,0.05313572,-0.037148863,-0.014666674,-0.012408831,0.031037489,0.032173,0.011072365,-0.015114252,-0.035987366,-0.010600294,-0.055209886,0.06175961,0.003758953,-0.035097912,-0.045293503,0.027884373,0.09157974,0.0048236363,-0.028545823,0.04137044,-0.09655182,-0.03458132,-0.07020424,0.02932188,-0.075435005,0.061213065,0.057130817,-0.054816466,0.06813431,0.032126065,-0.043480657,0.083831534,0.048061714,0.026654936,0.022844467,0.0026060136,-0.060321007,-0.04847505,-0.04868226,-0.041471455,-0.012312412,-0.101303235,-0.012989893,-0.055743996,-0.083981454,-0.13558336,-0.05701272,0.049690034,0.023277555,-0.026007708,0.050383568,-0.09542593,-0.036318257,-0.023420423,0.060981765,0.017778479,-3.7678227e-08,-0.0050380793,-0.03120432,0.056386355,0.0323894,0.0516428,0.036213085,0.0030871425,-0.05328294,0.09624908,-0.062865615,-0.069273055,0.12011496,0.10717648,0.02974123,0.030587163,0.0003985249,0.012163852,0.027740575,0.0031497215,-0.058114465,-0.04402438,-0.024623662,-0.05886598,0.055101097,0.008101743,-0.057017878,0.018327931,0.059969395,-0.052899625,-0.05292074,-0.054537114,0.019411903,0.016731817,-0.003639809,-0.008423295,-0.041222706,-0.030920768,-0.026510738,-0.035575666,0.051478557,0.04200946,-0.011191019,-0.1520921,0.0211004,0.010278239,0.0062904432,0.022388583,0.03508182,-0.011781824,-0.06151767,0.05034156,-0.018155519,-0.034218967,-0.018652981,0.014987984,-0.047701158,0.0038481078,-0.07567031,-0.017030751,0.0022104892,0.032572728,0.06646995,0.1644726,-0.04508244 +3.1.1.94,Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.,384,0.99999994,-0.0026724883,0.060570918,-0.14538378,0.08476154,0.062246025,0.0132503295,-0.11627295,0.061857034,0.0037417787,-0.060310487,-0.012529581,-0.05594758,-0.04017293,0.020783367,-0.0975148,-0.0239535,-0.003957368,0.02315139,-0.0105183385,-0.019773984,0.052321244,0.06598852,-0.032268163,-0.0054688384,0.0048188246,-0.028962906,0.035521813,0.0025420354,-0.0440335,-0.07900381,-0.05482425,-0.030995172,0.006467728,-0.034034025,0.09421334,0.057072107,0.028175455,0.020980017,0.11642732,-0.026125947,-0.013224916,-0.04191642,0.0106723765,-0.05703652,-0.08631478,0.012190062,-0.060562607,0.032369778,0.03903646,0.0076498007,-0.115665525,0.015410186,-0.008810716,0.0677489,0.12977543,0.007724327,0.03156322,-0.07838226,-0.051525507,-0.013091251,-0.009831963,-0.030913165,-0.020937383,0.038334385,-0.079964474,0.003612928,-0.036504727,0.0114410715,-0.023373568,-0.079610415,0.016125064,-0.046825882,0.06562501,-0.022916304,0.09051329,0.026609467,-0.04002272,-0.022220176,0.08249529,0.012089477,0.100251436,0.060219247,0.058506247,0.041201904,0.020319263,-0.0567611,-0.011929886,0.08478074,0.011763156,0.08401379,0.0009578939,0.06720106,0.062207974,0.02015675,-0.014845741,0.014759522,0.09276599,0.028019754,0.0055845995,-0.028774245,-0.025122974,-0.023225928,0.018700022,-0.010119447,0.060518466,-0.022942176,-0.005662104,0.04443388,0.062184405,0.011984627,0.03335861,0.015487352,-0.055817522,-0.08824675,0.058899887,-0.029697075,0.08751251,-0.05215725,-0.026455073,0.022170223,0.036575235,0.019470055,-0.0053415434,-0.0021204068,0.0851699,0.0018587732,-0.065052375,-1.0808248e-33,-0.003197335,0.038121425,-0.0781659,0.0033815173,0.12017553,-0.07401124,0.041041516,-0.05765585,-0.021030217,0.07676603,-0.08734821,-0.032968946,-0.118462354,0.044749033,0.033447575,-0.02594224,-0.010689414,-0.05061406,0.022770861,-0.006894672,0.022076657,0.009128694,-0.04374497,0.018729573,-0.0047653476,0.05118486,-0.023187134,-0.0316994,-0.004489107,-0.0008732435,0.066961184,-0.042471964,-0.094198175,-0.03571232,0.06865589,0.016148997,0.0067199846,-0.024219662,-0.13294603,0.009093314,-0.0024628015,0.02216315,-0.009024299,-0.11614606,0.040900722,0.02500599,-0.087549195,0.04833984,0.08044811,0.0030340154,0.10181253,0.012231459,0.088422105,0.0079126125,0.024852285,-0.042086534,-0.08195886,-0.0019692236,0.052775532,0.071527325,0.039633714,-0.02884526,-0.03389379,0.07630294,0.044694353,-0.03828803,0.0042157094,-0.0074911434,-0.017608719,0.018682683,0.03041912,-0.06572592,-0.031288173,-0.0053195534,-0.019402407,-0.009545758,-0.072741166,-0.0391962,-0.030836776,-0.027997475,0.034559205,-0.00015180431,-0.011549316,-0.016585592,-0.09964409,0.04663356,-0.027736854,0.04170179,0.018519789,0.017479133,-0.0048978673,-0.036521237,-0.04446708,0.053565856,-0.028796718,-1.2999572e-33,0.07515918,-0.06509259,0.024057824,-0.08343066,-0.085353635,0.073169924,-0.02122686,0.033205383,0.031348392,0.0248076,0.0021224853,-0.011341383,-0.011527719,-0.013035855,-0.008787105,0.057546977,-0.002537049,0.08387623,0.05698888,-0.0060225576,-0.05870607,0.054035887,-0.08724294,0.008450941,0.00039303122,0.058972605,-0.010087591,0.09246462,-0.00052585796,0.019205187,-0.02373231,0.056445107,0.03736871,-0.038501028,-0.058726113,0.10204202,-0.06417716,0.018884886,0.0120933475,0.03127956,-0.02607755,0.029003127,-0.04924093,0.0446081,0.05839387,0.025932277,0.0041491706,-0.0045148083,0.06828292,-0.029083274,0.016932491,0.012420565,-0.03017219,-0.03282088,-0.03535657,-0.038018342,0.0072587496,0.000564443,0.08211699,-0.05844579,-0.01907879,-0.014611452,-0.040738117,-0.015657634,0.08647746,0.08197591,-0.05972112,-0.075754374,0.038132668,0.014298066,0.021580756,0.008630003,-0.019072015,0.068294145,-0.006708467,0.009201631,-0.023164477,0.0038750626,-0.006994992,0.07883261,0.03956372,-0.0047692293,0.07538068,0.007023563,-0.07171483,-0.14456163,0.12857972,0.026316449,-0.081644125,0.001387065,0.029346319,0.048412044,-0.046072185,0.011399903,0.045143623,-2.4412596e-08,0.046317413,0.020143265,0.006922763,-0.07883854,0.0019151748,0.015324611,0.019214764,-0.012678966,0.026190432,-0.033485763,-0.09351466,0.043838974,0.0069858073,0.06329215,0.05247145,-0.02043595,-0.040868826,-0.003296365,0.007697841,-0.02380045,-0.08673811,0.011967852,-0.046856195,-0.01978585,-0.046902552,-0.00094183156,0.026812326,-0.036732383,0.09929008,0.053150613,-0.05629103,0.07664708,0.042206954,-0.106624834,-0.11448585,-0.013442752,-0.08979318,-0.09114478,-0.017159116,-0.063912876,-0.03892034,-0.08288545,-0.02156096,-0.06179048,-0.08893509,-0.026460804,-0.044659983,-0.0017300901,-0.016967604,-0.021643763,0.107659884,-0.008673914,0.045960117,-0.041067332,-0.060757007,0.006991901,0.045250695,0.0024330576,-0.005593892,-0.0744218,-0.058913648,0.011193796,0.12754402,-0.014802698 +3.1.3.89,"The enzyme, characterized from the bacterium Escherichia coli, shows strict specificity towards deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. A divalent metal cation is required for activity, with cobalt providing the highest activity.",384,1.0,-0.021209024,-0.10420281,-0.0685843,0.018117595,0.0480897,-0.027094256,0.006952455,0.0649591,-0.012236938,-0.006800254,-0.046136573,-0.047400136,-0.040088564,0.08195271,-0.0428264,-0.035755694,-0.022816513,-0.0023464914,0.021153104,0.05815195,0.05503663,-0.058762405,-0.047226015,-0.010339974,0.016326517,0.060928307,0.007232988,-0.026268203,-0.062165707,-0.010013171,-0.06079972,-0.05411461,0.046621807,-0.042883035,0.077580765,0.08047279,-0.042260744,-0.07019829,0.03349061,-0.015740035,0.0020147238,0.054036565,0.048587225,0.01921473,-0.053867105,-0.064707726,0.055666547,0.015422261,-0.019055225,0.019789305,-0.017527208,-0.014801672,-0.014129898,0.016781848,-0.023331085,0.014511131,-0.042660203,-0.053529922,-0.021202544,-0.05583256,0.055058572,-0.05784236,0.028792627,-0.003133169,0.090822056,-0.0071096057,0.062231928,-0.058492865,-0.025224451,-0.025725648,-0.011118207,-0.038763836,-0.018218488,0.003932759,-0.0264448,0.07425241,0.08084883,-0.103910275,0.0619034,-0.034053467,-0.03517022,0.037841868,0.053471863,0.023916576,0.03221421,0.073756754,0.0009556404,-0.003462204,-0.0053132745,0.07616482,-0.005776556,0.013066744,-0.008531961,-0.04077205,-0.09028061,0.038296547,0.05972711,0.10205759,-0.035328314,-0.022473432,0.053605855,0.10658159,-0.059839077,-0.022432525,-0.0074608903,-0.017318668,0.057442024,0.07643175,-0.015593247,0.027959898,-0.003413918,0.013450335,-0.0081674885,0.0058872253,-0.034200218,0.06030433,0.060130134,-0.055982336,-0.06702185,0.054626755,0.04673169,-0.05384074,-0.006939696,0.017801983,-0.059948977,0.041482497,0.006096836,6.892493e-33,0.030464897,-0.006645777,0.061550956,0.006725316,0.03347679,0.054417454,-0.08896804,0.032026447,-0.03002765,0.004172086,-0.10917212,-0.036876224,0.10843828,-0.03669125,-0.04719519,-0.01761813,-0.059264056,0.02465024,0.03840588,0.038415145,0.05773311,0.09176219,-0.02594213,0.051322423,0.04792098,0.03803488,-0.08410055,0.014565184,0.022971977,-0.0126344375,0.04764156,-0.099537075,-0.10113276,-0.013299019,0.13672806,-0.083318755,-0.04785435,0.015513911,-0.006340408,-0.020990571,0.061491102,0.01022432,-0.0891611,0.021677727,0.072266676,-0.053476054,-0.01887846,0.08471597,-0.10262148,0.00974739,0.038552113,0.019222753,0.09079362,-0.09441932,-0.0018829291,0.014891009,-0.012835122,0.039997857,0.08334946,0.09347314,0.029457975,0.06893758,-0.0033121568,0.023782747,0.026502905,0.010446286,-0.058044713,-0.05348516,0.06358947,0.068544336,-0.02485068,-0.01608988,0.03842748,0.05003784,-0.0054530525,0.004058272,-0.01155629,-0.021421324,0.057740238,0.008396136,-0.023387909,-0.024662953,0.036884192,-0.07683777,-0.06286215,0.0043827184,-0.04722995,-0.08158146,-0.020824179,0.033091553,0.055906296,0.006091985,-0.09206268,-0.070507616,-0.016637513,-7.704481e-33,0.06617895,-0.08740944,0.027172761,-0.078826524,-0.14310776,0.04613944,-0.048628125,-0.08124123,0.10000424,0.0003130865,0.12296074,0.007886254,-0.004131668,-0.01907553,-0.0027119848,0.034362108,-0.04493522,0.07494978,0.052958127,0.01397622,0.013332388,0.07345507,-0.034467638,0.003415904,0.04706121,-0.004266139,-0.07531816,-0.033100013,0.067602195,-0.0029525617,-0.021773532,0.052562807,0.06267725,-0.052428048,-0.05661302,0.014394711,-0.024821263,0.014281761,0.016808039,0.029333103,-0.036087345,0.011619171,-0.035110693,0.11283319,-0.0015570452,0.019035386,-0.1353154,0.0070726904,0.005657913,0.016878953,0.02435171,-0.10556088,-0.06507449,-0.009611346,0.117740944,0.03543842,0.031315535,0.0013070484,0.018021727,-0.015944283,0.003977566,-0.00716734,0.020760436,-0.0063731973,0.040123705,0.03805875,-0.06251454,0.037656803,0.030306144,-0.05453271,0.04196979,0.106484324,-0.0017187294,-0.054700598,-0.079431094,-0.039373413,0.044302624,-0.005950739,-0.007542701,-0.0535038,-0.050227396,0.053025544,0.0065901456,-0.06901393,0.034850094,-0.058446176,0.07190873,0.08679456,-0.062082022,0.037936438,-0.048777483,-0.08536602,-0.025533047,0.042008065,0.006608756,-4.3887738e-08,-0.016082963,0.02260409,0.0011354571,-0.07429446,0.006710102,0.08466039,0.03632484,-0.06664421,0.05901529,0.024092322,0.08319867,0.04413677,0.013267625,-0.047948293,0.08637912,0.0015359209,-0.06869432,-0.039407555,-0.042056214,0.05202568,0.0045062164,0.014332677,-0.07067084,0.025770979,0.059071325,-0.07188588,0.017997276,0.02542925,-0.060689602,-0.04034339,-0.03154584,-0.024754409,0.056677245,-0.07692534,-0.035036124,-0.020428894,-0.054584205,0.01821559,-0.08258826,0.038126886,-0.06642801,-0.053297404,-0.044676833,0.0025107204,-0.061557166,0.0064007947,-0.07507821,0.08605611,-0.025153544,-0.034371298,0.03512265,-0.05144184,-0.0012920499,-0.0282214,-0.06821063,0.0880268,-0.009202975,-0.057226464,-0.07238508,-0.0119126635,0.020178046,-0.00530595,0.09741272,-0.06208794 +3.1.4.56,"Contains one zinc atom and one iron atom per subunit of the dodecameric enzyme. It hydrolyses 7,8-dihydroneopterin 2',3'-cyclic phosphate, a step in tetrahydromethanopterin biosynthesis. In vitro the enzyme forms 7,8-dihydroneopterin 2'-phosphate and 7,8-dihydroneopterin 3'-phosphate at a ratio of 4:1.",384,1.0,-0.040463984,-0.00014397946,-0.10114368,-0.029864086,0.05950521,-0.039118048,-0.010531454,0.04199364,0.015977822,-0.014004296,-0.025559092,-0.069551505,-0.020902459,-0.0127927745,-0.06331185,-0.036786586,-0.09449231,0.025923874,-0.022838945,-0.015161264,0.05016444,0.046226177,0.027504278,-0.008188804,-0.010096724,-0.022117436,0.016261596,-0.003949672,0.013026771,-0.007394302,-0.041354623,-0.00061902613,-0.026400642,-0.03722332,0.049538124,0.07022254,-0.058319677,0.0077115777,0.014525766,0.034752283,0.0858924,0.022740047,-0.05282797,-0.07225574,-0.008557228,-0.066866234,0.004607965,0.027237447,0.014731892,0.08593051,-0.05031021,-0.07756056,0.02661489,0.090060115,0.010516213,-0.07198021,0.008797775,0.075925775,-0.03824605,0.020899314,0.042200144,-0.05622585,0.013755902,-0.005030901,0.070507586,-0.030428147,0.014228288,-0.063601196,-0.042364206,-0.081403956,-0.034627754,0.021495707,0.0036355762,0.03365887,-0.06307404,0.057064343,0.01915023,-0.022652049,0.014155137,-0.019617807,0.08024501,0.0467724,0.061820716,0.16306053,0.10736613,0.034163103,-0.05161535,0.034656815,0.023127599,0.02761475,0.06811488,0.027204627,-0.018099226,-0.014675175,-0.049154725,0.0819064,0.0018906321,-0.016617794,0.0060354914,0.045267183,-0.011361956,0.04380777,9.049098e-05,-0.08915079,-0.024472767,0.0482109,-0.027722968,0.073942535,0.007838491,0.041695617,0.01160789,-0.009680171,0.03777948,0.049810365,-0.0083891535,0.040062383,-0.028764307,-0.038200106,0.02068153,0.0024647566,0.06682131,-0.013788885,0.06853987,0.10217583,-0.010898878,0.01056507,-0.07751663,2.3347617e-33,0.055816785,0.052631516,0.03540132,-0.027738241,0.030503673,0.01186673,-0.024558824,0.04521703,0.012132938,-0.0017433426,-0.09894072,-0.13633275,0.066227905,-0.06621077,-0.05488954,-0.09995683,0.003715744,0.006288223,0.051062435,0.038705662,0.05981681,0.1288012,-0.08043345,-0.012290268,0.050222617,0.08886335,-0.07163115,0.0043962332,0.029701518,-0.012642027,0.015829397,-0.08788232,-0.08682629,-0.018880455,0.14303465,-0.091914505,-0.009731153,-0.009737314,-0.039349418,0.016474942,0.020352587,-0.04521721,0.020205515,-0.015877169,0.08147159,-0.04966587,0.011120785,-0.0078508295,0.040297333,-0.02995474,0.03936313,0.065011814,0.05143682,-0.087993965,-0.14130469,-0.036008984,-0.05274669,-0.009118974,0.09326686,0.08029568,-0.03131338,0.0015302392,-0.032858506,0.011064692,-0.03472051,-0.029061843,-0.06802107,-0.04102885,0.0044815396,0.09333006,-0.021611303,-0.03347145,0.038262323,-0.02329372,0.016378986,-0.0077379905,0.02687969,0.0008688393,0.051091842,-0.02919452,-0.02816945,-0.07362208,-0.046233505,-0.0038115492,-0.051784314,-0.018129567,-0.02983747,-0.065596,0.018566241,-0.035757594,0.048422236,-0.019715859,-0.11373438,-0.05183801,-0.014253203,-3.769763e-33,0.033346947,-0.015077104,0.049071394,-0.104140826,-0.051450323,0.03884545,-0.057187274,0.004541764,0.016049284,-0.03432294,0.10418154,-0.013530689,0.0019182231,-0.07308419,-0.05141463,0.120933466,-0.004582971,0.14805771,0.073773734,-0.032367475,0.053884882,0.03840942,0.038313042,0.047405515,0.049533732,0.0014501725,0.028071212,0.053924635,0.13794048,0.089233495,-0.007755489,-0.013800602,-0.014158278,-0.0137550365,-0.095713,-0.012137323,-0.07886321,-0.01464151,0.050792675,0.047262587,0.056490943,-0.056198273,0.04088703,0.06348497,0.07137611,0.04819363,-0.095618,0.025532078,0.01657651,-0.012376551,0.050378192,0.013248859,-0.037036695,0.029676711,0.07917723,0.037978116,0.057437472,0.001978563,0.009793686,0.02407396,0.014344941,-0.042757332,-0.009084407,0.021581752,0.025887936,0.06289494,-0.057615705,0.08609199,0.014918695,0.022663683,0.026594054,0.015571699,0.0062482334,-0.009279025,-0.016087623,-0.07603665,-0.020549392,0.00035257393,-0.0011284006,-0.017847288,-0.032265678,0.030764474,0.0046909302,-0.04787326,-0.068988994,-0.03957397,0.07923381,0.06742456,-0.018053984,0.03534772,-0.011329436,-0.021511542,-0.010928485,0.039985742,-0.025613213,-3.993437e-08,0.05605709,-0.101659685,0.01652202,-0.11691871,-0.015581313,-0.049739577,0.019373469,-0.02789454,-0.06854137,-0.026646735,0.020182364,0.023470249,0.0056520696,-0.008005358,0.07525799,0.037797082,-0.0341482,0.03337974,-0.030502522,0.022826979,0.02882102,-0.007463049,-0.076833226,0.035116497,-0.010227122,-0.025444921,-0.050467927,0.029875573,-0.019460779,-0.04219088,-0.03235579,0.022587324,-0.0012807638,-0.052517414,-0.119279474,0.031290334,-0.065285966,-0.093115084,-0.033255477,-0.04162307,-0.08358978,-0.049099084,-0.0075343004,-0.004627407,-0.008447884,-0.07349746,0.0030967174,0.034910478,0.020860782,-0.040588353,0.029875334,-0.008691551,-0.014378511,-0.06556915,-0.024276173,-0.010053674,-0.005875544,-0.0660499,-0.041991297,-0.04757955,0.029963002,0.013737783,0.1892929,-0.07406595 +3.1.6.19,"Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III sulfatase family. The enzyme from the bacterium Rhodococcus ruber prefers linear secondary-alkyl sulfate esters, particularly octan-2-yl, octan-3-yl, and octan-4-yl sulfates [1]. The enzyme from the bacterium Pseudomonas sp. DSM6611 utilizes a range of secondary-alkyl sulfate esters bearing aromatic, olefinic and acetylenic moieties. Hydrolysis proceeds through inversion of the configuration at the stereogenic carbon atom, resulting in perfect enantioselectivity. cf. EC 3.1.6.1, arylsulfatase (type I), and EC 1.14.11.77, alkyl sulfatase (type II).",384,1.0,-0.11320977,-0.12627757,-0.08381677,-0.014424655,0.058600828,0.014019152,-0.12465853,0.026124857,-0.0015565522,-0.058144797,-0.017006109,0.00032477372,-0.07398373,0.07492663,-0.027317524,0.023281926,-0.060400534,-0.003168338,0.016099365,0.02848314,0.07593597,0.039247595,-0.08854496,0.0032902604,0.042545207,0.050969917,0.06807594,0.028313883,-0.07421467,0.031046072,-0.015894696,-0.06795818,0.045840297,-0.073803455,0.07260091,0.024588732,-0.041152887,-0.013083343,0.07815436,-0.017169207,0.04576953,0.045704972,0.044533994,-0.124388345,0.018300626,-0.07077679,0.015307737,0.034619328,0.04724743,-0.06872706,-0.030491577,-0.025379727,-0.040952966,0.086509675,0.00025180404,-0.027907185,-0.050148893,-0.018108945,-0.0019068731,0.011040708,-0.008204347,-0.011684819,0.019643836,-0.06404159,0.01733231,-0.029456493,0.03029647,-0.07676586,-0.0066707353,-0.012294385,-0.16822122,-0.023190495,-0.02412705,0.060360316,0.004129824,0.031043569,0.047003057,-0.03960762,0.04113452,-0.09653787,0.007095758,-0.021865515,0.014144676,0.11393451,-0.0025565003,-0.012938506,0.0134958,0.018822297,0.053057976,0.08894527,0.03786291,-0.0020512412,-0.038888793,-0.059854973,-0.014991264,0.019727776,-0.00884718,0.18314734,0.031703193,-0.018583087,0.043720663,0.0046530357,0.010716539,-0.14311871,0.021715354,-0.0019925828,0.012265919,0.13804033,0.042744458,0.02542696,0.026771393,0.031024126,0.024164056,-0.035342682,-0.0536876,0.09917439,0.04012989,-0.06965482,-0.11983716,0.018604323,0.046182968,-0.029769044,0.08317289,-0.007342428,0.040774897,0.00010571579,-0.12691702,2.105203e-33,0.024183577,0.042738724,0.03841146,-0.046379123,-0.053714342,-0.014763902,-0.09970061,0.047298547,-0.02389914,0.016462076,-0.016612152,0.008633703,0.039026465,-0.03677332,-0.036246337,0.018072803,0.009718857,0.036173616,-0.002051873,-0.0038103983,0.06798278,0.054594327,-0.04390805,-0.0129855955,0.043151777,0.041768115,0.04530451,-0.01872965,0.0051852935,0.0013335312,0.05664437,-0.12033477,-0.081549026,-0.02256016,0.10598748,-0.05535577,-0.021373246,-0.040031243,0.036506932,-0.047227956,0.050287448,0.04743322,-0.041184776,0.034984373,0.037363995,-0.028910143,-0.021078816,0.09175412,0.0018140521,0.07781731,0.013023096,-0.051621594,0.09608013,0.011849251,-0.014285402,-0.050027676,-0.012850807,0.032735545,0.08290999,0.018138314,0.018937603,0.04959642,-0.046498824,-0.008906843,-0.02342167,-0.008274861,-0.023334078,-0.008655314,0.042623315,0.08386303,-0.047681108,0.006994793,0.015021626,0.08066881,0.009501917,-0.077899866,0.0110871205,0.024682423,0.067988746,0.0066917217,-0.09981351,-0.028901488,0.045606796,-0.0036637522,-0.14054148,0.00245749,-0.027367089,-0.0031983126,-0.044653844,-0.018431988,0.016163815,-0.0317356,-0.08976051,0.05819159,0.010732826,-3.0969302e-33,0.08743093,-0.059578523,0.014522004,-0.14329025,-0.09198102,0.00026259205,0.040661577,-0.0068762642,0.015761672,-0.105701774,0.073612824,0.020158783,0.07627706,0.013698617,0.052182037,0.04515695,-0.053791933,-0.0038606806,0.0030632894,-0.01879664,0.045951057,0.08346114,0.021878066,0.07990767,0.0017577566,0.033190742,-0.014337863,0.059517935,0.04757704,0.105685435,0.006192969,0.030627122,-0.018255502,-0.07714523,-0.056287806,0.02369758,-0.023331845,-0.010862038,0.017736342,0.05688243,0.032896075,-0.023445848,-0.03715925,0.091041915,-0.017397223,0.042745057,-0.03995329,0.05354426,0.02482105,-0.06430267,-0.0062593394,-0.013851598,-0.022821913,0.042087045,0.01637009,0.016570047,0.0010646314,-0.01806351,-0.0784444,-0.013243091,-0.058843404,-0.074170604,0.016753795,-0.05664569,-0.025774227,0.03526514,0.037241988,-0.05542764,0.010344671,-0.037458096,0.022451997,-0.003269456,-0.05340503,-0.046358358,-0.04563195,-0.032607425,0.025883224,0.058848415,-0.010602065,0.016672565,0.028489556,0.055791643,-0.002061151,0.0036951983,-0.0009308906,-0.041230097,0.0020910027,0.10627726,-0.062119097,-0.007143814,-0.016078044,-0.028724397,-0.01938243,0.07045395,-0.043876607,-4.5548198e-08,-0.022958653,-0.021644125,0.091421545,0.0010274624,-0.008011546,0.077566214,-0.03687235,-0.0152987,0.016579986,0.05080267,0.028873794,0.05198628,-0.020138504,-0.02181425,0.09795319,-0.016005121,-0.08901195,0.0017135399,-0.04153606,0.0008731166,0.009814704,-0.07654464,-0.09889921,0.0046461998,0.047115978,-0.061009027,-0.0029675646,-0.06894973,-0.07142371,0.060396012,-0.01716839,0.04527466,0.0058190706,0.0027855404,-0.02090617,0.01245009,-0.029743444,-0.01555369,-0.048345655,0.02170938,0.041522883,-0.003441314,-0.11837382,-0.0039662356,0.024367224,0.0079320315,0.013141046,0.03146328,0.01997016,0.008618426,0.052098364,-0.022269396,0.016883802,-0.013405479,-0.035549,0.0519539,-0.0040034973,-0.06401156,-0.005253388,0.077171855,0.083330356,-0.019124806,0.08998217,-0.012694494 +3.2.1.185,"The enzyme, which was identified in the bacterium Bifidobacterium longum JCM1217, removes the beta-L-arabinofuranose residue from the non-reducing end of multiple substrates, including beta-L-arabinofuranosyl-hydroxyproline (Ara-Hyp), Ara2-Hyp, Ara3-Hyp, and beta-L-arabinofuranosyl-(1->2)-1-O-methyl-beta-L-arabinofuranose.In the presence of 1-alkanols, the enzyme demonstrates transglycosylation activity, retaining the anomeric configuration of the arabinofuranose residue. cf. EC 3.2.1.55, non-reducing end alpha-L-arabinofuranosidase.",384,0.99999994,-0.03389545,-0.050867252,-0.027253343,0.00046708062,0.013363132,0.049117602,-0.07350381,0.022618422,0.055964045,0.0100770835,-0.004141818,0.03949955,-0.027451828,-0.02091684,-0.019650513,0.056919325,-0.07393163,0.053057462,-0.0015807003,-0.013098379,0.12355727,-0.03586327,-0.046260014,0.029772788,0.026997484,0.016286667,0.054828107,-0.011708697,-0.054157104,-0.018298266,0.005976178,-0.0064631714,0.068004906,-0.090501584,0.030617692,0.056057297,-0.028734941,-0.06218676,0.103450775,-0.020638335,0.10328329,-0.013765876,0.052542876,-0.052210193,-0.0509595,-0.0013802833,0.062177382,0.008922064,0.07932121,-0.020781355,-0.05771446,0.016254159,-0.08900997,0.040634114,0.0066735386,-0.061609935,0.010420749,-0.00457308,-0.019527314,0.09668345,-0.017320933,0.04711945,0.0046057086,-0.009842956,-0.078501254,-0.07030769,0.033151012,-0.07524492,0.012886966,0.0036014845,-0.10057434,-0.017905641,-0.0013350857,-0.018971669,0.052823324,0.039531447,-0.008365987,-0.029645298,-0.034340683,-0.034293715,0.03374912,-0.072229125,0.055262648,-0.02471433,-0.061371434,-0.08789359,0.037477355,0.0046257107,0.04868419,0.085858986,0.083209224,0.0051886723,0.048829414,-0.08687313,0.016734207,-0.014352551,0.021081273,0.002649692,0.012816087,-0.0028890006,-0.007136837,-0.0003902034,0.072538495,-0.07240192,-0.046969533,0.044244286,-0.033653494,0.1127452,0.09299514,-0.008954422,0.013860005,0.021592107,0.05156063,0.010829722,-0.046986833,0.038376447,-0.034160048,-0.112268664,-0.06663864,0.05240025,0.007788445,-0.07912312,0.09946793,0.061901223,-0.014411571,0.08974778,-0.08331727,1.8749111e-34,0.06284371,0.0059633213,0.0025979802,-0.07634241,-0.055267468,-0.043811213,-0.068279535,0.012152847,-0.05716313,0.0014114606,-0.01710916,-0.03127691,0.03669775,0.073449545,-0.08218796,-0.013730247,0.019514086,-0.011408774,0.059296776,0.028706001,-0.0077573317,-0.010924661,0.033066813,-0.008347623,0.07156952,0.046654887,-0.0026480267,0.03519831,0.022647593,-0.0028953778,-0.014625059,-0.03857377,-0.09847786,-0.03314906,0.078435324,-0.0047202003,-0.033941433,-0.04622224,-0.021970913,0.0016718353,0.020047469,-0.017460756,0.021984907,0.008031936,0.06670594,0.02283302,-0.00830361,0.074450724,0.03252767,0.09315152,-0.0053788233,0.026450671,0.06435568,-0.028219108,-0.01961558,0.0033612556,0.01692728,0.013675301,0.011936312,-0.0040475447,-0.018384486,0.041400373,-0.040962197,0.0034582913,0.011738141,0.011932102,0.007219488,-0.00077642006,-0.014159463,-0.0365425,-0.009328968,-0.03745851,0.13295084,0.08628067,0.013949519,-0.031927865,-0.06387021,-0.04363155,0.08724628,0.0054236427,0.0086948,0.04151541,0.035970375,-0.053785693,-0.07922599,0.022246812,-0.01531892,-0.034601636,-0.023576701,-0.028768014,0.014394484,-0.0037741186,-0.036891468,0.10983498,-0.009940311,-1.723062e-33,0.11318748,-0.11795006,-0.002484918,-0.046576068,-0.026052123,0.0039746054,0.103049174,0.04527598,0.00418658,-0.013296646,0.13992107,-0.060089264,0.017855326,-0.099977866,0.07224799,-0.04314017,0.035241324,0.050846092,-0.076509126,-0.004041226,0.030028094,0.040050358,0.0017917262,0.0039651217,-0.019566044,-0.020439364,0.011095875,0.07962064,-0.011703386,0.08044933,0.008167899,0.017653357,-0.04536365,-0.07097286,-0.033172872,0.041027077,-0.1058564,0.0035632201,0.010024307,0.019659052,0.07783942,0.04794801,-0.00346495,0.0085332105,0.037982415,0.00374,-0.0937327,0.04169308,0.053288884,-0.12085242,-0.056001224,0.025306799,0.011542026,0.0027969985,0.0004894049,0.041188635,-0.026293997,0.09291454,-0.025078714,-0.028646076,-0.074552536,-0.06332859,0.07987281,-0.05542573,0.05207327,0.059145864,0.026713151,-0.036484543,0.06614782,-0.022977998,0.024135249,0.023136146,-0.036677394,0.028887957,0.027207699,0.054459076,-0.109201506,-0.11916981,-0.09083176,0.0022632272,0.082914636,-0.007693536,-0.09088882,-0.054127622,0.004460188,-0.018685194,-0.0010282282,0.07748875,-0.06694893,0.0058841337,0.033607144,-0.046249695,-0.023157477,0.024292577,0.027251171,-4.329726e-08,-0.007040827,0.012039595,0.09285554,-0.036683965,-0.0052749612,0.095289364,0.0076927436,0.057433557,0.0011451542,-0.033609703,-0.010812286,0.017108792,-0.06030566,0.094701804,0.008749593,-0.0140466355,-0.07719978,0.021347426,-0.000312308,0.019672886,-0.09492231,-0.035087563,-0.12727953,-0.022843828,0.0068240277,-0.09777464,0.018482735,0.05888632,-0.04552458,0.01744711,-0.016038738,-0.012221239,-0.05463721,0.020819765,-0.019037224,-0.058676165,-0.043483913,0.0076558986,-0.040161565,0.052885234,0.0783319,0.009045797,-0.09260981,-0.0015089215,0.045302868,0.012401815,-0.02117965,0.06354195,-0.074488156,0.039915413,0.13493152,-0.0043530115,-0.08810194,-0.07086777,-0.021943966,-0.0057263025,0.015878038,-0.022941142,-0.072101906,0.028619584,0.024229417,-0.06489274,0.10898985,-0.06909054 +3.3.2.12,"The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 1.2.1.91, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway [1,3,4]. The enzyme from Escherichia coli also exhibits enoyl-CoA hydratase activity utilizing crotonyl-CoA as a substrate [2].",384,0.99999994,-0.09590786,-0.081234775,-0.0038382735,-0.02073643,0.13234079,0.0007012944,-0.07924945,-0.02299846,0.017646706,-0.062275507,-0.040784772,-0.068503395,-0.036670975,0.057573628,-0.012729649,0.028273266,-0.07222694,-0.03300109,-0.039611984,-0.047679834,0.06459239,-0.020571513,-0.056914512,0.0961634,0.110174716,0.029209346,0.06427145,0.028493209,-0.06267226,-0.028365392,0.021192035,-0.048222143,0.0073633725,-0.012790873,0.057865,0.09894866,0.013270571,-0.10376752,0.0885672,-0.0022915383,-0.013892514,-0.0010226795,-0.04129685,-0.037880637,-0.028158294,-0.048705235,-0.010072032,0.01596652,0.08599145,-0.027785812,-0.034865644,-0.037651468,-0.029500123,0.015414744,0.031007752,0.051510047,0.0012207114,-0.052283812,-0.029431451,0.014940301,-0.0057951286,-0.019271534,0.036470648,0.034770295,0.013134682,-0.092052124,0.009840165,-0.019428475,0.021734461,-0.018981237,-0.11236415,-0.060432773,0.03740577,0.054685026,-0.06384501,-0.0071675293,0.003368697,-0.054007467,-0.0073554097,-0.010722366,-0.023698153,0.009951555,0.014684262,0.068432346,0.04195591,-0.03520789,0.012856425,-0.04410136,0.0387183,-0.022314629,-0.017427517,0.008473104,0.032394264,-0.049714085,-0.03137854,0.09614488,0.011118711,-0.0052180067,0.027659876,-0.03940253,-0.03926216,0.12538321,0.027240384,-0.03471787,0.0448702,-0.021881409,-0.0007805023,0.19966854,0.0077657686,-0.03969885,0.013077589,-0.04254772,0.1005392,0.051432725,0.022409579,0.090688944,-0.02934476,-0.010781834,-0.048672654,0.04204518,0.01228403,-0.053583723,0.056009274,0.034687426,-0.01585656,0.02616774,-0.05065204,4.1086628e-33,0.06276593,-0.015941609,-0.021276005,0.006717027,-0.0047637387,-0.0018839235,-0.09262151,0.11210353,-0.05032113,-0.024296172,0.0048544114,-0.023489958,0.0910808,0.0005452958,0.008731928,-0.059130512,-0.021506818,0.014758329,0.025161397,0.07222428,0.008643773,0.019706277,-0.0007975482,0.034507837,-0.04500313,0.07070922,-0.017209113,0.06548107,0.047160767,0.011144259,-0.007043606,-0.05108856,-0.07333935,0.0060960525,0.05891716,-0.093674354,-0.09074913,0.031549517,-0.034073655,0.121117905,0.062283874,0.032984097,-0.045275204,-0.078208975,0.028152576,-0.019858984,0.0033106944,0.08384428,0.0070490395,0.007223893,0.034591258,-0.0011804729,0.11085683,-0.06397055,-0.026007356,0.016080044,-0.0038498014,-0.025370259,0.07734538,0.0013112591,-0.037854422,0.037129134,-0.037807647,0.031281002,0.018956212,-0.009092601,-0.036491144,-0.060436077,0.02935551,0.07575537,-0.025987387,0.06381904,0.012403695,0.028221035,0.059464235,-0.07144117,-0.0306844,0.023966402,0.03561001,0.0079030795,0.02445253,0.03697302,0.04612354,-0.014259241,0.00620332,-0.0035203623,-0.023770744,-0.0285075,-0.013775832,0.07707425,0.027859796,-0.13276017,-0.0014647613,-0.06951139,-0.022103699,-3.3456626e-33,0.11807342,-0.10746588,0.02126302,-0.14683178,-0.09885085,0.1046573,-9.6881966e-05,-0.0012461607,0.0101170605,0.014724285,0.104449704,0.07505785,0.005522719,-0.03462836,-0.0013626248,0.05506057,-0.013412021,-0.014164403,-0.029262867,-0.004610626,0.072994106,0.056166552,0.044975456,-0.032892108,0.11482081,0.044713367,-0.01594361,0.021429352,0.040402774,0.016976144,-0.009088316,-0.05051186,0.007847557,0.035742685,-0.048947893,0.0628683,-0.09750103,-0.0032462948,0.027299516,0.02905609,9.059805e-05,0.017730858,0.0035091033,0.00937374,0.0032822443,0.01053001,-0.10243045,0.0008285754,-0.03386141,-0.03687842,0.015468509,-0.057384655,-0.086855516,-0.010978523,-0.017781164,0.0061660903,0.028017947,0.012677867,-0.019591343,-0.033469364,-0.027073983,-0.014383999,0.03659616,0.03266187,-0.002079852,0.04604233,-0.047924973,0.09885215,-0.0017235597,-7.203747e-05,0.06244938,-0.021686265,0.069142915,0.02501149,0.021295486,-0.022163795,-0.056716148,0.02047985,-0.028962761,0.04811822,-0.042095624,-0.03277367,-0.056909986,-0.067181736,-0.06867457,-0.0889932,0.016643541,0.07194988,0.0004893268,0.010967721,0.023766672,-0.07737431,-0.009899721,0.07023937,0.12860674,-3.9912525e-08,-0.008037309,-0.08317862,0.046899125,-0.010277254,0.048273273,0.038943484,0.0118489405,-0.050001483,0.055873614,-0.011364892,0.032491505,0.013680123,0.06008648,0.020133737,-0.046375394,-0.0346698,0.01233031,-0.008954923,0.011264215,-0.022737753,-0.030393738,-0.025402727,-0.084067896,0.07770264,0.05479265,-0.055893887,-0.036739945,-0.0073466776,-0.06143229,-0.05352381,-0.031973023,0.022405764,0.01961162,0.0028841787,-0.036185354,-0.01706447,-0.023486113,-0.03974759,-0.10609058,0.06538326,0.045848288,-0.0026675516,-0.10867114,-0.015953459,0.0672581,0.066594794,0.02341977,0.006618945,-0.031149302,0.00068716676,0.06764117,-0.01793406,0.026443986,-0.006400205,-0.092214674,0.0033865871,-0.008978247,-0.10966973,-0.06500659,-0.033659924,0.028199853,0.040460788,0.18584172,-0.034310237 +3.5.3.24,"The enzyme, which has been characterized from the hyperthermophilic archaeon Pyrococcus kodakarensis and the thermophilic Gram-negative bacterium Thermus thermophilus, is involved in the biosynthesis of spermidine.",384,1.0,-0.07739057,-0.01512965,-0.15664238,-0.028427914,-0.025066262,0.05030036,-0.047822867,0.026388507,0.027620152,0.0580971,0.044869054,-0.07431404,-0.05646296,0.093485,-0.018997999,0.015487625,-0.06993235,-0.019584665,0.07582664,-0.014452142,0.13603517,0.044928025,-0.03185813,-0.004435406,0.0137226535,-0.01433385,0.009048696,0.017444193,-0.03745462,0.036833156,-0.07040527,0.0026019046,0.054950934,-0.05522773,0.0997533,0.08780527,-0.07821012,-0.0039644013,0.10169237,0.0011886235,0.07617515,-0.048561774,0.013168682,-0.0017641349,-0.06791595,0.083316006,0.08991396,0.027189806,0.041620716,-0.006174373,-0.07154011,-0.027094774,0.007771676,-0.03364386,0.015354701,0.038969517,0.025389263,-0.09316883,-0.06792283,-0.047731154,0.011102131,0.029326443,-0.04469238,0.044113375,0.033393547,-0.05662853,0.04013558,-0.022752859,-0.010969437,-0.038184237,-0.06768167,-0.03571863,0.0019784376,0.04989099,0.0091340635,0.05918649,-0.036667973,-0.017487954,0.0063678115,-0.07108597,0.07844102,-0.07671127,-0.042378053,0.062176757,0.011211017,-0.026528254,0.10635296,-0.0014612189,0.08697405,0.0026422704,-0.009089062,-0.03252959,-0.0030086078,-0.048194744,-0.03283527,0.014918116,0.019671315,0.033233624,0.0063828747,-0.07101654,-0.019306893,-6.06569e-05,-0.048500244,-0.062211055,-0.026351523,-0.022568213,-0.07089298,0.053841364,0.09744125,5.4343727e-05,-0.028579408,-0.005314521,0.04030106,-0.009297522,0.0147877,0.03608797,0.034805093,5.481809e-05,-0.06720882,0.041320466,-0.04537081,0.006708304,0.03890892,0.07046147,-0.0751036,0.014317153,-0.081066184,3.819251e-33,0.082697235,0.029137801,0.04043199,-0.020315329,0.048328836,0.063177556,-0.046043057,-0.082280025,-0.031041048,-0.107255,-0.030185722,-0.060051996,0.02683332,0.059704293,-0.04401846,0.015006158,-0.03174842,-0.009272646,0.031206515,0.036257368,-0.043494303,0.11580376,-0.025138563,0.026050668,0.018459197,0.054524865,0.0028120375,0.021679537,-0.009183808,-0.0037915907,0.036731716,-0.085514665,-0.12338409,0.016877687,0.077826805,-0.010816225,-0.076788045,-0.061225723,-0.057365473,0.001995249,-0.0274934,-0.026061622,0.013450932,-0.0007843147,-0.026788626,-0.018147273,-0.017032463,0.10304884,-0.0010367035,0.078488246,-0.00011077861,0.010320419,0.08240652,-0.029486252,-0.12432988,0.026886368,-0.02174942,0.017430712,-0.011949239,-0.008723874,-0.0063971397,0.032812335,-0.037728593,0.06937905,-0.046373397,0.009836207,-0.040020622,-0.062138103,0.011001458,0.10113361,-0.067918845,0.01935765,-0.025282677,0.005244871,0.013953151,0.014429795,-0.08988282,-0.04431297,-0.027634146,-0.074268095,-0.041590884,0.025130508,0.017041072,-0.01586013,-0.075427376,-0.017133823,-0.03210826,0.0113470815,0.020689907,0.0128418645,0.016839137,-0.1307581,-0.031479333,0.04130404,3.0260071e-05,-5.422312e-33,0.04693996,-0.120422065,0.007218299,0.0037730315,-0.014682637,0.066613704,0.08032414,-0.00683611,-0.11358952,-0.030749705,0.07852643,0.0032075369,0.030289385,-0.05469253,0.06096347,0.02997265,0.037441988,0.07055942,0.07033552,0.0046694805,0.029662196,0.062234994,-0.035776746,-0.060080983,0.013662894,-0.012905906,-0.020326365,0.06486677,0.049386606,0.014110716,0.0049984255,0.10011625,-0.06470034,-0.032492988,-0.023418628,0.047968995,0.018154677,0.039154086,0.10922598,-0.0013774475,0.012516248,0.03922098,-0.0041260337,0.029257577,0.0436714,0.053393308,-0.049160905,0.017075457,0.0388427,0.030920945,-0.027148586,-0.016702423,0.008907693,-0.05156342,0.007551756,-0.027044555,-0.060441505,-0.008921836,0.015334556,0.003930296,-0.07398784,-0.08291626,0.03510845,0.078321524,-0.04145528,0.07980685,-0.041529763,0.044184633,0.05869509,-0.03307598,0.12573932,0.01255263,0.015208748,0.013171616,0.003486188,-0.05061704,-0.03337548,0.0024547798,0.06317812,-0.008125548,0.0011456966,0.03531298,0.044381168,0.010692314,-0.009817288,-0.051020075,0.10090462,0.039121836,-0.01843728,0.0136083625,0.013589438,-0.014041596,-0.010425104,0.056864556,0.08587786,-3.768351e-08,0.07546099,-0.047374595,0.10970012,-0.05512686,0.04852646,0.01673382,-0.0019285759,0.019715052,0.04680134,-0.061274596,0.0042975782,-0.0060732597,0.0401417,0.06474336,0.04118694,0.020393977,-0.040015027,-0.0062754345,-0.043537196,-0.01405467,-0.044159062,-0.075029835,-0.14031412,0.07677462,0.01449451,0.037672322,0.011175532,-0.073918365,-0.017446533,-0.0744798,-0.038999006,0.0007905507,-0.081539825,-0.039657347,-0.13837788,0.02981351,-0.06781002,-0.039291244,0.0007087923,0.005958147,0.029687844,-0.05008947,-0.013872016,0.052986126,0.051715236,0.019083535,-0.048298046,-0.007906917,-0.06869357,0.029775249,0.03073444,0.03701849,0.0019893527,-0.027050586,-0.13158993,-0.03820687,0.021858333,-0.03773119,-0.061291154,0.010909236,0.029139694,0.050733037,0.14808555,-0.020243434 +3.5.4.37,"This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4]. +",384,1.0,-0.014307128,0.0007707534,-0.028450908,0.004883059,-0.011835406,0.01726206,-0.07559872,-0.0068318537,0.013351296,0.101234086,-0.02622656,0.015145557,-0.07783442,0.01794432,-0.04325081,0.10785688,-0.075190894,0.026760133,-0.032083586,-0.07973025,0.06983941,0.048291508,0.0355628,-0.009129143,0.01441202,-0.002281907,0.051608328,-0.0018933194,-0.016812915,-0.09684325,-0.09065193,-0.049621522,0.068374835,-0.0041540856,-0.043648735,0.13529184,-0.044116467,-0.058035217,0.07440727,-0.005629898,0.049445957,-0.02833716,-0.059750788,-0.025783435,-0.04604003,-0.008099802,-0.025224766,0.026795227,0.047524888,0.05096232,-0.0075619677,-0.014489463,-0.043309815,-0.040848527,0.0009677109,0.07524229,-0.0234795,0.0547356,0.033452954,-0.062228907,0.06387796,-0.0035641382,0.011463013,0.042295758,0.062700205,-0.101374336,0.07270105,0.00013861051,-0.053280666,-0.030706381,0.0458099,-0.040186007,-0.054358475,0.12654598,-0.020025542,-0.03996523,-0.03283767,-0.012277181,0.04853992,0.038470354,0.0573015,-0.022881778,0.022540232,-0.011636796,0.014050907,0.09993096,-0.00021953907,0.032950576,0.03701968,0.046691716,0.013899966,-0.013006678,0.0014656937,-0.03505813,-0.016153492,0.01113015,0.025597211,0.064743504,0.011521426,-0.026639689,0.077022955,0.07955951,-0.09667716,-0.027850457,-0.022146523,-0.04865703,0.09334909,-0.04787082,-0.03477002,0.045701355,-0.002920296,-0.032537956,0.039484076,-0.033159886,-0.030459095,0.066903435,-0.0020929375,0.015600429,0.0116864005,0.05714442,0.01875197,-0.057380635,-0.015973298,0.1476675,-0.09555539,-0.01328858,-0.057758853,2.5115822e-33,0.05943631,0.012663413,-0.0027833553,0.008939027,0.0014688197,0.00960423,-0.034910273,-0.03719997,-0.12232031,-0.09163711,-0.054946184,-0.06945596,0.02422205,0.03518894,0.002748864,-0.054356813,-0.011703608,0.04657784,0.00751215,-0.00036670515,0.012745602,0.04313414,-0.04889765,0.019831741,-0.030432161,0.018654764,-0.024286844,-0.023080628,0.11525766,-0.035325177,-0.013279618,-0.0033815242,-0.123715095,0.051363952,-0.012761539,-0.08916314,-0.017022261,-0.06910306,0.023894312,0.075435586,-0.014608641,0.007596758,-0.027250709,-0.06307453,-0.0114928875,-0.029018518,-0.004663099,0.039660424,-0.056547847,0.014525114,0.09171,0.019999916,0.029942634,-0.106676884,-0.019906485,0.009824599,0.03365997,-0.10268098,0.025285028,0.08694915,0.007124477,0.006392142,0.013691975,0.06679046,-0.0038418765,-0.0076556704,-0.057186153,-0.10582499,0.011003278,0.0438455,-0.08693222,-0.0421868,0.047028314,0.01650491,-0.08747041,-0.033840068,-0.08304712,-0.01806404,-0.011444803,0.058132302,-0.010519558,-0.09621828,-0.012032854,-0.025152728,0.0093369,-0.039449897,0.0060275323,-0.045612987,-0.013297594,0.046268545,0.05695079,-0.056729037,-0.106394455,0.0018047653,0.09750224,-5.22109e-33,0.02764692,-0.04382961,0.025129853,-0.014598538,-0.13037285,0.06932378,-1.9523446e-05,-0.1003597,0.07992098,-0.023138983,0.036348574,-0.014287597,0.049227063,-0.048928864,-0.038354605,-0.016539697,-0.02583899,0.028597116,-0.086928405,-0.024315197,0.006580967,0.05489854,0.047243588,0.08109984,-0.0029960137,-0.044178504,-0.04203559,0.038080025,-0.0039599254,0.023735218,-0.0550044,-0.033855043,-0.04817173,0.027396915,0.0028043098,-0.0102919685,0.054818824,-0.014008213,-0.010591616,-0.050050654,0.035837777,0.08915535,-0.023479464,0.11326723,-0.012049484,0.061174385,-0.082135335,0.05132983,-0.0012896433,-0.06232934,0.008709208,0.0204292,0.0046307687,0.021397587,0.06361611,-0.015637152,0.004343062,-0.031154597,0.030633464,-0.021173287,-0.08980125,-0.05581897,0.022945264,-0.03674172,0.082375735,0.06928369,-0.021204058,0.06418152,-0.0061430545,-0.072542354,0.08133221,-0.04675874,0.029233444,0.01389073,0.03674791,-0.05777575,-0.020103218,-0.068291344,0.0022821203,-0.04196128,-0.071675174,-0.034888394,-0.042038146,-0.03690558,0.019807452,-0.012957544,0.045578595,0.11094755,-0.03394857,0.06738869,-0.005950924,0.04059653,0.010146803,0.063765675,-0.02582375,-3.1677825e-08,0.017987493,-0.049321223,0.006542113,-0.04885422,0.031992014,-0.0036779419,0.026557941,0.045966294,0.10856338,-0.020523887,-0.04167175,0.038782787,0.019659057,0.0046590315,0.08641583,0.031892266,-0.062352777,0.08199036,0.022545911,-0.041814107,-0.04821256,0.011942822,-0.11008739,0.03874821,-0.010490027,-0.009912261,0.099258,0.09649845,0.02174585,-0.0028450517,-0.060974766,-0.0077029048,0.050532807,-0.011738679,-0.098104626,0.020945434,0.09998206,0.019131701,-0.0341724,0.021667026,0.0020197295,-0.00037931345,-0.044423822,-0.024352603,-0.06437384,0.008045292,0.042965326,0.050963048,0.028666178,-0.024206799,0.023379054,0.057524677,0.03317636,-0.06467235,-0.0883833,0.02958978,-0.060865305,-0.028782107,0.0010531723,0.028282085,0.006765436,-0.013442237,0.18256353,-0.077928215 +3.5.4.38,"The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences. +",384,0.99999994,-0.030432152,-0.011402494,-0.006579286,0.0046887225,0.05547187,-0.02529314,0.026185406,-0.016185515,-0.020739708,-0.022378907,0.013070811,0.07478043,-0.037337966,0.07102806,-0.050463825,0.13795593,-0.09485819,0.030437086,0.010749755,-0.104090884,0.038897414,-0.042586446,-0.010435467,0.030414684,0.020152926,-0.0013389376,0.021077767,-0.019819759,-0.009329993,-0.09913101,-0.02751104,-0.0687828,-0.0017534394,-0.0052035064,0.010402823,-0.02750402,-0.07722375,0.017523272,-0.01789216,-0.013434436,0.07966417,0.03967538,-0.039417915,-0.0033243408,-0.044683,-0.042320035,-0.029943548,0.06828645,0.032978572,0.06385884,0.010422784,-0.042373452,-0.03918231,0.010189234,0.016318569,-0.009990614,-0.14463112,-0.03257234,0.0055814637,0.019658016,0.039774045,-0.018185737,-0.023101447,0.016684046,0.13282275,-0.042418856,0.051205657,0.012841781,-0.023634067,0.035088465,-0.0016504477,-0.09354493,-0.0734258,0.0071037333,0.0742036,0.019931454,0.0054758308,-0.028501196,0.034213375,0.061040677,0.019993111,0.0065300623,0.05946569,0.036142074,0.04993817,0.033850927,0.003597677,0.0066967816,0.06707612,0.009275474,-0.010172002,-0.011977605,0.01225812,0.00017625984,0.0017733296,-0.04879894,0.04169722,0.10375966,0.011656555,0.015085248,0.060482938,0.015216484,0.011701782,-0.078374796,-0.015402031,-0.009203382,0.014320863,0.052749578,0.0056054355,-0.02371766,-0.07537302,0.0109089445,0.06888917,0.030919695,-0.03793634,0.07066633,0.013858832,0.0015441023,-0.032431822,0.015444409,0.034200046,-0.065417215,-0.009668792,0.06564831,-0.037630364,0.123219065,-0.10562617,3.860849e-33,0.026295261,0.0064518875,0.012007551,0.03744521,-0.026704427,0.007507067,-0.01737722,0.02152206,-0.071763046,0.079345435,-0.052405473,-0.03418433,0.0683876,0.05366847,-0.007239933,-0.062159587,0.03951691,0.030229064,-0.024668897,0.021768356,0.015064919,0.08614322,-0.113602236,-0.020903405,0.014361748,0.04644988,-0.06381174,0.07235858,0.048641585,0.010447763,0.022303756,-0.059164904,-0.11513596,0.026433762,0.1329073,-0.012354403,0.0070761517,0.0030150975,0.059450336,0.07477736,-0.041351415,-0.039244097,-0.016879123,-0.042470254,0.114208475,-0.015269717,-0.042560875,0.009011628,-0.05602383,0.027233247,0.10739499,-0.00628118,0.03442949,-0.023201117,0.002529517,-0.0012459313,0.03190856,-0.021939898,-0.010325155,0.058042377,-0.06060829,-0.039988402,-0.08197706,-0.033047143,0.0061874716,0.034385994,-0.046108644,-0.061160427,-0.048129242,0.07808789,-0.017456606,0.019227328,-0.004924166,-0.020894842,-0.015228929,-0.0141821895,-0.00483403,0.024407642,0.027480463,0.01894501,-0.043510906,0.06466435,-0.026806545,-0.024061253,-0.024984138,-0.06766558,-0.028053597,-0.100628495,-0.07608901,0.027661147,0.099784724,-0.0037954566,-0.0526983,-0.035829887,0.034394767,-4.7113127e-33,0.098191984,-0.06713601,-0.001312542,-0.075863615,-0.08015778,0.0057917438,0.08908005,-0.014896962,0.072735526,-0.036168687,0.04119498,-0.051573697,0.0152090965,0.053751405,0.018982388,0.01630988,0.01694628,0.08166994,-0.056139275,0.027332153,-0.014084374,0.09896092,0.07523344,0.0048194183,0.02154864,-0.008836185,-0.024379142,0.12439496,0.10563191,0.00664654,-0.15340404,-0.010041559,0.036957785,-0.05311475,-0.019524219,0.08880115,0.007276251,0.008503672,0.020127418,-0.023238666,-0.081860825,0.021266824,-0.014220856,0.076232545,0.0412477,0.10802706,-0.0580793,0.035437375,-0.004795081,-0.0048247804,0.044902574,0.0018955335,0.008637487,0.010078684,-0.032290805,0.006295375,0.023578174,-0.0044971174,0.016553976,0.018772932,-0.014486579,-0.048273087,-0.0061021405,-0.0069645084,-0.008163946,0.010733557,-0.008708114,0.088180654,-0.028909838,-0.124222,0.019958906,0.0405136,0.050409876,0.002560455,-0.011401886,-0.009447055,-0.05674721,-0.078422174,0.011075376,-0.06624046,-0.0830015,-0.0068294853,-0.008877352,-0.044559233,0.020303404,-0.026205856,0.041681193,0.06212152,4.131815e-05,0.029477151,0.03579458,-0.077119514,0.042718444,0.020443274,-0.048713434,-4.2171635e-08,0.056549314,-0.1186078,0.023897735,-0.10142379,0.0017655352,0.10508124,0.002541962,-0.008960074,0.05043381,-0.025848169,0.005353537,0.106283635,-0.06528528,0.045003828,0.054449826,-0.02602416,-0.09066509,-0.048057977,-0.02913041,-0.015211862,-0.06682537,0.042966403,-0.17257409,0.093032315,0.0027366502,-0.006339704,0.08631428,0.052361175,-0.0046119476,-0.015837142,-0.02477102,0.022792296,-0.030701082,0.018687217,-0.10861595,0.010091777,-0.018655328,0.02373642,-0.04310466,-0.017788045,-0.009841116,0.0177292,-0.05316666,-0.07013099,-0.08592809,-0.0327063,-0.02230723,-0.014171604,0.0023718511,0.029348526,-0.0066044694,-0.07669037,-0.046402737,-0.06352896,-8.367016e-05,-0.058134247,0.039024677,-0.06592526,-0.047022544,0.0011736287,-0.0062109483,-0.00039859506,0.17252842,-0.0513846 +3.5.4.39,"Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29).",384,0.99999994,-0.07672944,0.010396414,-0.07153351,0.012233014,0.11348789,-0.01681715,-0.08070004,-0.023174316,0.019064972,-0.05758083,-0.07817585,-0.08990515,-0.012316023,0.007054357,-0.079670325,-0.012147464,-0.048265316,-0.00920514,0.017670458,-0.01711607,0.06047176,0.11629631,-0.017773226,-0.02450816,-0.04996015,-0.048619427,0.014989854,-0.0032008262,-0.019534966,0.017023649,-0.057323564,-0.007350964,0.07246429,-0.023489093,0.018458616,0.13133249,0.010277358,-0.015665827,0.019325761,-0.011043199,0.05626408,0.03854258,0.07761221,-0.035670124,-0.017530987,-0.0040388326,0.08580472,-0.03558335,-0.00466494,-0.04046224,-0.06545721,-0.02341552,-0.026898708,0.038843766,0.06747624,0.072576955,-0.058577035,-0.089164756,-0.017429242,-0.06734167,-0.006719073,-0.012487658,0.002321161,-0.037535906,0.042502254,-0.029288806,0.02696646,-0.07043661,0.026418071,-0.03040926,-0.043457184,-0.0018141653,-0.06923816,-0.014922216,-0.089065254,0.07641874,0.02705028,-0.06809416,0.06953084,-0.055636905,0.025495958,0.007815783,0.015760722,0.055837058,0.07299931,-0.0048170793,-0.0060858424,0.02089097,-0.05014771,0.03899738,0.07019957,-0.009170505,0.020639043,-0.021550307,-0.08042973,0.0062577915,0.06786575,-0.026074283,-0.0029061635,0.007628914,-0.0041292715,0.04226054,0.04188343,-0.080240086,-0.07702773,-0.027978184,0.0052322214,0.14833727,-0.00038670722,0.090680405,0.05037807,-0.073848344,0.066992424,0.019797428,0.024051242,0.076998614,0.025213959,-0.054538738,-0.07919054,0.012862991,0.006311237,0.0143043315,0.032836046,0.05685257,-0.02428823,0.06191103,-0.12507051,4.0053023e-33,0.060936045,0.016994372,0.009847032,0.0038685475,0.013826347,0.041323453,-0.087427996,0.0005955573,0.02762395,-0.012924727,-0.057866465,-0.07763313,0.060657993,-0.05766541,-0.07616564,-0.030660013,-0.02520658,-0.044023745,0.010346284,0.018812431,-0.017199984,0.065101504,-0.014853203,-0.02184459,0.068615206,0.02356464,-0.010506038,-0.09325986,0.06959391,-0.016206848,0.030500628,-0.11318149,-0.13279016,0.002892392,0.1503809,-0.0072557568,-0.0049962588,-0.04916816,-0.051612686,-0.043644775,-0.020322423,0.024084186,-0.008853717,-0.037487853,0.0673829,-0.014555408,-0.034368683,0.1379903,0.024559628,0.04701454,0.032107286,0.008309586,0.037061498,-0.032657117,-0.12803756,0.0144011285,-0.00994039,-0.0022861129,0.05078398,0.08772062,-0.0387551,0.04087833,-0.02273918,0.08671231,-0.001341039,0.03685119,-0.048311405,-0.023297219,-0.0040163994,0.10264062,-0.014276237,-0.029928643,0.07714217,0.062252335,0.022320706,-0.07470138,-0.047244392,-0.074960835,0.07458211,0.023053102,-0.023588603,-0.08221018,0.0057903617,-0.00037594733,-0.049815755,-0.0050386093,-0.032681867,0.010834574,0.041342355,0.021432921,0.025270946,-0.025735186,-0.016812341,0.050487116,-0.021482574,-5.2041677e-33,0.05464998,-0.06780953,0.076425806,-0.10017708,-0.038103264,0.048085585,-0.0569353,-0.12503922,0.03435341,-0.102735974,0.11257059,0.0077636847,0.07364699,-0.026464673,0.028376482,-0.030728567,-0.04398086,0.09411419,0.03666677,0.029313752,0.04498652,-0.003906576,0.018766053,-0.0049774996,0.0779223,0.0026589287,-0.001035428,0.08011804,0.037629623,0.057023413,-0.018513879,0.07214365,-0.079168595,-0.10870125,-0.12615693,0.0053766454,-0.011244404,-0.02769933,0.0076212455,-0.007246731,0.04644523,0.07078231,-0.009684708,0.08140229,0.061474074,0.06924245,-0.030263703,0.042626873,0.030630479,0.008564234,-0.011591563,-0.050532315,-0.038872678,-0.033846654,0.023160653,0.041392438,0.048228715,0.05294048,0.018768592,-0.024648758,-0.028746752,-0.052815028,0.03652106,0.013087899,0.022747183,0.014564666,0.03706555,0.09191103,0.016873997,0.010061128,0.0473797,0.050398532,0.09413711,0.037169743,0.015891328,0.011047629,-0.044604614,0.010027727,0.04420912,-0.020745005,0.010353187,0.06632275,0.053784687,-0.0034208011,-0.04884569,-0.0681125,0.09366175,0.03377005,-0.037311498,-0.015980294,-0.081573464,-0.024531966,-0.034872256,0.011891123,-0.04906097,-4.128734e-08,0.035981666,-0.027895693,0.03495497,-0.13688904,-0.0045771566,0.024465969,0.038908083,-0.015095228,0.02890657,-0.034876924,0.035711985,0.069658086,0.02266646,-0.011506422,0.016154932,0.031438503,-0.017725851,0.00581725,-0.034015138,0.006824871,-0.03534609,-0.019275075,-0.0868317,0.05627324,0.002269909,-0.0873493,-0.004261227,0.048114546,-0.009985152,-0.04218323,-0.020868745,0.010707731,0.039570183,-0.044206765,-0.07197048,0.015500165,-0.06901399,-0.06198503,-0.0023122812,-0.037035573,-0.043342635,-0.0020387457,-0.025918698,-0.039868265,0.0049598175,-0.0422928,-0.010029477,0.04235194,-0.02324703,0.029502593,0.03907276,-0.042517498,0.06792554,-0.08836306,-0.0011097378,0.009295656,0.011022099,-0.045435015,-0.037530277,-0.0035805814,0.01466062,-0.020498568,0.13371934,-0.049609862 +3.6.1.65,"The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-dCTP and 8-hydroxy-dGTP.",384,1.0,-0.07862387,-0.04184595,-0.045721944,-0.11120305,0.02530871,0.049547505,-0.06517361,0.1074242,-0.004974696,-0.014676928,0.023604512,0.03269565,-0.13233717,0.09489146,-0.015906341,-0.0039148214,-0.03215929,0.013466337,0.05427755,-0.07776104,0.007275558,0.018581063,-0.06481443,-0.029709058,-0.042140566,0.060765866,0.091274366,0.0012452768,-0.045930468,-0.024849366,-0.04868267,-0.085388884,-0.011922003,-0.022552555,0.09419385,0.09645978,-0.09747323,-0.040727153,0.094227195,0.0073736934,0.08240714,0.025849093,0.028149532,0.049107935,0.014293575,0.004447981,0.0031139285,0.08128201,-0.070666626,-0.03425195,0.010210625,0.029855832,-0.009081413,-0.015525574,-0.016564408,0.007880108,-0.034090508,-0.049825627,0.0086592175,-0.018396253,0.009359897,0.042997263,0.025949042,-0.0066578644,0.06863868,-0.0632332,0.10384864,-0.027773064,0.071784906,-0.038183197,-0.073740244,-0.025626976,-0.0018252035,0.07309255,-0.04018982,-0.022387218,-0.020715186,-0.056700796,0.07541613,-0.011121831,0.012605248,0.013154681,-0.009074926,0.041797604,0.07098873,0.0073187323,-0.020936646,0.061976798,0.056492995,-0.00090597634,-0.02008379,-0.014459255,-0.06567669,-0.005469965,-0.11021781,-0.00094683917,-0.033563312,0.00087234355,-0.040162653,-0.055515833,0.047658026,0.083465,-0.063859165,-0.032524083,-0.04515981,-0.097952634,0.030608892,0.041101873,-0.013337838,-0.043887906,-0.045516226,0.12842356,0.011749501,-0.057008088,0.026948376,0.012633343,-0.037342366,-0.038956363,0.005990341,0.006683003,-0.017112019,-0.07606736,-0.033609033,0.08488058,-0.061313957,-0.015529984,-0.07809289,-1.3480775e-34,0.024352316,0.04185578,0.03064147,-0.045967564,0.055797618,0.01629259,-0.05818246,-0.017221196,-0.114177585,-0.011048267,-0.054649323,-0.107880265,0.054818258,0.063614324,-0.07593453,-0.011080012,-0.05542563,0.07911438,0.03367023,-0.084849656,0.019471977,0.15236337,0.008764029,0.06571178,0.05444996,0.060243625,-0.06314476,0.05734915,0.0721142,-0.0075463415,-0.019845963,-0.07616173,-0.07604522,0.05528729,0.09203073,0.0032500278,-0.057816572,-0.061077658,0.026987782,0.07151691,0.009621396,0.038465872,0.0030509974,0.02232485,-0.006717826,-0.0026337737,-0.0933675,0.046069738,-0.026685728,0.016324893,0.0598806,-0.045614623,0.04941428,-0.048182994,-0.028795896,-0.01451763,-0.06368456,0.0075407797,0.029778251,0.060729664,0.06167517,0.0492415,-0.06655113,-0.042695083,0.0136444345,0.033994675,0.0033378664,-0.060337126,0.14692429,0.106457785,-0.048192915,0.010099485,0.09177709,0.03614883,0.078196645,-0.030598242,-0.063239165,0.065105006,0.0023774544,0.022372555,-0.10440298,-0.054499064,0.0337618,-0.03204876,-0.034025338,-0.030946221,0.003170463,-0.010837275,0.00524964,0.014131084,0.0954013,-0.038614884,0.021621102,0.02413064,0.02665265,-1.8181625e-33,0.019903753,-0.08366559,-0.008841639,-0.088404715,-0.0806716,-0.0021270013,-0.0032398775,-0.09681015,0.006719065,-0.045904275,0.10178182,-0.004059263,0.0005463501,-0.0007997967,-0.009711039,-0.0065086028,-0.034009997,0.07179243,0.0023756719,0.014954644,0.007729766,0.0041400096,-0.020512681,0.10570446,0.077273056,0.030072624,-0.0014942734,0.01929113,0.084532194,-0.02391317,-0.013387019,0.055551328,-0.05588829,0.015614432,-0.036831725,0.021300662,-0.059605535,0.08060246,0.0126602715,0.02972373,0.07530912,0.04076799,-0.01748104,0.06508751,-0.038140595,0.06329681,0.004036481,-0.024961572,0.009099715,-0.030433686,0.017753016,-0.01377553,0.034329057,-0.012216691,0.053396117,0.042661067,-0.014228737,-0.012721113,0.0039646295,-0.02746614,-0.04777859,-0.07679854,-0.015138706,0.03419379,0.035316713,0.021124817,-0.012608296,6.652073e-05,0.02303594,-0.034613207,0.026604898,0.07923025,0.043966938,-0.0040705428,-0.11709798,-0.08208759,-0.028615542,0.025753314,0.052306484,0.007914501,0.020888498,-0.0024436133,0.006092607,-0.047730736,-0.036809646,-0.013949989,0.010864495,0.077265665,0.05871693,0.0007270536,-0.027075917,0.007023637,-0.012910018,-0.008398983,0.02069977,-3.569509e-08,0.06034345,-0.054936487,-0.022184161,-0.06248736,-0.019450184,0.08567087,-0.019185172,-0.012326438,0.07364036,0.020408202,0.028418226,0.07753219,-0.00018267993,-0.055737223,0.00973163,-0.0032864453,-0.06434625,-0.0139139285,0.030566463,0.011363106,-0.09223926,0.040610284,-0.12403081,0.026080396,0.02751767,0.008658064,0.01961733,0.04982074,0.009934953,-0.028510002,0.0051124026,-0.008599887,-0.010939548,-0.03614095,-0.041236084,0.049542014,-0.0026163333,-0.030376062,-0.01820466,0.03056556,0.008727865,-0.04505856,-0.06402697,0.018774027,0.01570331,0.028585881,0.011209836,0.006919729,-0.06703852,-0.01047744,0.00834296,-0.004039224,0.005663941,-0.05271237,-0.09634232,0.013132221,-0.045327567,-0.09414399,-0.10967235,-0.041503485,-0.0030222966,0.043780446,0.18701354,-0.004007093 +4.1.2.51,"The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase. ",384,1.0,-0.019438395,-0.072313406,-0.05186477,-0.036938306,-0.035066508,-0.06061792,-0.07283083,-0.013701697,0.056693133,0.057506952,0.022753894,0.018036352,-0.029246368,0.05266584,-0.07331503,0.0016201057,-0.053949315,0.014901558,0.034379654,0.057219714,0.14380497,0.031062318,0.015270303,0.040672418,0.10088825,-0.028133154,0.0712017,-0.016854608,-0.104377545,-0.041118927,-0.02703992,-0.0783256,0.04152621,0.007636975,0.017631896,0.12235068,-0.027637202,-0.0239884,0.0059034857,0.0010351462,-0.013687373,-0.037465084,0.0042118165,-0.021054547,-0.05629467,0.0026923774,-0.03365654,0.07155598,0.034872383,0.015158376,-0.042929,-0.06503013,-0.04546435,-0.029827317,0.03418318,0.057155546,0.01754161,0.011032426,-0.03074758,0.021999106,0.059151657,0.048237916,-0.055133097,0.018867504,-0.009092838,-0.046226393,0.036000144,-0.043609273,-0.04233549,-0.091995545,0.031879537,-0.09224211,-0.0219822,-0.047652297,0.011641124,0.07619167,-0.006761591,-0.055752933,-0.014650327,-0.038290177,0.0855247,0.019668372,0.03835637,0.036955997,0.03518551,-0.04903869,0.047975153,0.013835045,0.02624205,-0.05273034,-0.011723008,-0.02864085,-0.07050096,-0.018634252,0.028130507,0.015111584,-0.0029221773,0.04098196,0.0009432554,-0.043334123,0.0029720925,0.015626313,0.0053542126,-0.037534915,0.022213327,0.0406901,0.046592966,0.13271482,0.01644083,-0.020886917,0.027986478,0.019861476,0.05109776,0.052909892,-0.043291163,0.09375489,0.053138234,-0.08538576,-0.097441085,-0.033494823,0.016454084,-0.036139768,0.066097125,0.0076850755,-0.04439196,0.06902504,-0.00476409,1.478563e-33,0.12006001,0.023912955,0.009131197,0.031521633,0.038351294,0.030780721,-0.08847758,0.019182438,-0.06716924,0.023162395,-0.11865202,-0.0096403295,0.060033944,0.07118966,-0.045487553,0.02308924,0.038424186,-0.021414379,0.09460719,0.00681382,0.00990644,0.081600636,-0.015997658,0.012652427,0.03764468,0.059660386,0.022216031,0.0020536834,0.012250107,-0.019777242,0.032872945,-0.114172,-0.10002951,-0.0124213165,0.00074246083,0.025438331,-0.056004956,0.020663163,-0.0104314815,0.0045523997,0.042404436,-0.0019449494,-0.024505118,-0.096287996,0.023784416,0.011007303,0.024310753,0.054028798,-0.0008003249,0.116401345,0.102197684,-0.0066585937,0.039750066,0.02594681,-0.08061059,-0.0044689993,-0.034635417,-0.02917688,0.099988535,0.07219809,0.03456737,0.06400083,0.013920202,0.057413004,0.021090284,-0.023056783,-0.053813104,0.019656857,-0.0464443,0.041891284,-0.0559795,-0.06962608,0.016145587,-0.02279343,-0.014292282,-0.027018884,-0.015374137,-0.014131162,0.0149203,-0.012172811,0.052972507,0.052671093,0.0049484274,0.040011555,-0.02500548,0.06753121,-0.02619053,0.0011708479,-0.054149114,0.0842141,-0.046554007,0.024180593,-0.09713765,0.026135439,0.060624976,-3.2472745e-33,0.10812559,-0.12500007,0.076244645,-0.120649315,-0.060836837,0.09943649,0.027156712,-0.022766072,0.06976089,-0.055284407,0.084148385,0.023511682,-0.010894331,-0.0886979,-0.004744006,-0.0172939,-0.07410362,0.0074396194,-0.06806133,-0.003195639,0.053147167,0.12015305,-0.05212915,-0.027843358,0.05701289,-0.026375568,0.04101807,0.06385703,-0.0023365607,0.017147992,0.045748435,0.018753693,0.009985974,-0.045001928,-0.013280129,0.11444737,-0.101661414,-0.0016351312,0.0011005307,0.039544694,-0.049720064,0.038188092,0.054528173,-0.007472751,0.06797105,0.04552398,-0.08911566,-0.0693142,0.004979171,0.013343651,0.060532965,-0.03635358,-0.036646597,0.03913802,0.07887912,0.013962965,-0.0097390255,0.047078717,-0.045267854,-0.040525507,-0.030078705,-0.014358533,0.06921346,-0.10471217,0.030155567,0.00019141742,-0.05584225,0.0039596795,0.01934608,0.025380764,0.04899799,-0.016294276,-0.054897282,0.017405292,-0.008132022,-0.001312529,-0.12569512,0.014242584,-0.00291609,-0.030553041,0.016838912,0.006968924,0.028976,-0.00884099,-0.02227502,-0.070626244,0.095887154,0.06684747,-0.0273636,-0.00035000197,-0.004734645,-0.054855604,-0.003941062,-0.032191142,0.099290736,-4.3312355e-08,0.021426547,0.01671947,0.014800417,-0.045058798,-0.07370617,-0.010615966,0.059729975,0.039005585,0.02469609,-0.06376712,0.04116143,0.092518024,-0.018923873,0.004462749,-0.01164962,0.020078463,-0.06352059,-0.028988415,-0.012773618,0.0015662023,-0.03611129,-0.016659655,-0.14861308,-0.029438548,0.016140854,-0.071115986,0.0010594903,-0.017281145,-0.020574346,-0.0286611,0.09340989,0.008538219,0.007683335,-0.07646119,-0.041065276,-0.03101654,-0.09169875,0.0057148817,0.018908866,-0.033054538,-0.019548934,-0.088200875,-2.2115933e-05,0.014898757,-0.10322679,0.043676455,-0.0164312,0.057848617,-0.047821984,0.08775565,0.035218757,0.03361177,-0.035886567,-0.08021319,-0.08062965,-0.006723933,0.049177755,-0.0534862,-0.006186756,-0.0770667,0.042096246,-0.033265937,0.0974182,-0.032478265 +4.2.1.138,"A multifunctional enzyme which also forms (+)-beta-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-beta-caryophyllene synthase].",384,1.0,-0.06819624,-0.04547884,-0.057062153,0.030176248,0.030149959,0.091451764,-0.020513669,0.02199648,0.033074874,-0.03431449,-0.047281217,-0.013115241,-0.09518651,-0.0075064,-0.03697654,-0.00064820517,-0.116782576,0.031587627,0.009839333,0.023098545,-0.005378173,0.0019707473,0.031946644,0.05245383,0.037105747,-0.023809733,0.023620635,-0.0459257,0.0025538674,-0.09017124,0.020633655,0.045758635,0.02461664,-0.056862235,0.061494093,0.04042518,0.0015715959,-0.11157753,-0.04896654,0.041507572,0.077762514,0.004259029,-0.021084711,0.013306704,-0.0040284307,0.004645305,0.041101955,0.044575248,0.03199363,-0.046613637,-0.06748202,-0.051741425,-0.03227065,-0.083028406,0.011398156,-0.0038473227,0.063844845,0.006831283,-0.036694348,0.06694078,0.06737348,0.024767788,-0.0327525,-0.034960993,0.0149776805,-0.026106654,-0.033868685,-0.040952716,0.09033528,-0.040091246,-0.14757651,-0.059074532,-0.05087439,0.066411614,0.048521325,-0.029399998,-0.019440364,-0.0066307383,0.06975523,-0.013559967,-0.014252257,0.008030561,-0.05136453,-0.044706184,0.036807388,0.078842945,-0.031324238,0.07183858,0.04691216,0.017827544,-0.016677776,-0.031266794,-0.039406743,-0.05164003,-0.07448643,0.063825384,0.010444623,-0.064922675,0.020388085,-0.033801116,0.012100474,-0.008175687,-0.042251408,-0.10084566,-0.043110188,-0.013226786,0.023143861,-0.0029938733,0.013785255,-0.03724874,-0.05444773,0.030498078,0.010296795,-0.03320963,-0.034348615,0.049396202,0.029443365,-0.077021606,-0.0066421414,-0.009246194,-0.0023826375,-0.06686028,0.019633098,0.11752152,-0.08147714,0.04172698,-0.120264076,-9.572046e-34,0.089402266,0.09083987,0.05195403,0.0067753405,-0.06154041,-0.010085039,-0.083835706,0.005157306,-0.1127395,0.00071479636,0.0054765297,-0.08076612,0.03227864,-0.0062969443,0.03366801,-0.019838328,-0.0515613,0.06118894,0.08950778,-0.06527264,-0.008672912,0.06041325,-0.06655924,0.05191315,0.084015064,-0.008512492,0.015275982,-0.0021902008,0.10868613,-0.017480876,0.045089226,-0.055016633,-0.063806236,-0.05316454,0.029284516,-0.08076205,-0.0917312,-0.088570155,0.017293826,0.105566174,0.01786911,-0.020772351,0.033569887,0.014865814,0.06878866,-0.040072393,-0.037208542,0.04925772,0.058821976,0.00682524,0.030552039,-0.0084800925,0.08783062,-0.02613721,-0.110603094,0.089868195,-0.043519117,-0.016476067,0.04741444,0.02651061,-0.035637934,0.057551857,-0.04161449,-0.10368301,-0.0029382987,0.023345154,-0.043920983,0.020639598,0.03288541,0.06760742,0.0032222366,-0.0596478,0.041130062,-0.006193563,0.04815372,0.02260514,-0.091256626,0.03370683,0.036989946,-0.017618664,-0.019454194,0.05140226,0.010672488,-0.105670236,0.01696282,-0.015759662,0.012713603,-0.013566057,-0.031666357,0.08254949,0.07050164,-0.014308936,-0.0246251,0.007629518,-0.016773399,1.028244e-34,0.06084947,-0.074369065,-0.057618443,-0.08777374,0.005044199,-0.07569192,0.01341921,-0.11918147,0.03638099,-0.029840004,0.020578507,-0.06428422,0.13069928,-0.048765928,-0.019824484,0.005428185,0.015257576,0.03226129,0.05960823,0.011037168,-0.040114034,0.010536912,0.08819117,0.06677088,-0.043551244,-0.019041741,0.014906114,0.07415972,0.08456997,0.026416983,0.04847123,-0.019122574,-0.005735031,-0.01124672,-0.05362658,-0.027041495,-0.0032702025,0.06657196,0.03555569,-0.027068391,0.0113256,-0.0078074266,0.0070551326,0.020271523,0.07028796,0.079806045,0.0016678383,4.1202402e-05,-0.0073034377,-0.014668163,0.0125878975,0.0054140007,-0.020648764,0.038633738,-0.0071959505,0.015280612,-0.026549565,0.0037370932,0.06575194,-0.054000236,-0.0032202255,-0.06851449,0.065339744,0.0125983935,0.09512641,0.09917486,0.031490617,0.010738506,-0.019889953,-0.05808209,0.0895267,0.04997829,0.004936489,0.09021578,-0.07660376,-0.0014963314,-0.027321827,-0.052898213,-0.018760938,-0.00061909383,-0.012531512,0.013999638,-0.05252078,-0.039717242,-0.034338683,-0.043779626,0.028730609,0.11906853,0.043570906,0.026760105,-0.02763425,0.060512036,0.0114778895,0.024152707,0.090046145,-3.1793416e-08,0.06299596,-0.025784537,0.012692599,-0.04732346,-0.033175662,-0.04202156,0.06337198,-0.023085436,0.00731968,-0.033585675,-0.03757925,0.03502993,0.07458284,-0.008865068,0.13236414,-0.029205954,-0.05008961,0.003404182,0.002764548,-0.01887008,0.039616507,0.0651187,-0.05512873,0.050131418,-0.053427108,-0.0012622096,0.03108966,0.021111699,0.049581964,-0.011389315,0.069700636,0.061488796,0.009237922,0.0025461637,-0.105125375,-0.0007309048,0.015009409,0.06045346,-0.022860713,0.048977435,0.0024115797,-0.0748326,-0.03295831,0.023411678,-0.03043061,0.0021936994,0.06560604,-0.014948763,0.0797227,-0.02720624,0.09811271,0.020660168,-0.014137409,-0.011103536,-0.052400745,0.0075939614,-0.0696426,-0.061378025,-0.004970272,-0.053141683,-0.03739338,-0.043926872,0.19840622,0.0200258 +4.2.1.139,"The enzyme catalyses the formation of the additional ring in pterocarpan, the basic structure of phytoalexins produced by leguminous plants, including (-)-medicarpin, (+)-medicarpin, (-)-maackiain and (+)-maackiain. The enzyme requires that the hydroxyl group at C-4 of the substrate is in the (4R) configuration. The configuration of the hydrogen atom at C-3 determines whether the pterocarpan is the (+)- or (-)-enantiomer. The enzyme contains amino acid motifs characteristic of dirigent proteins.",384,0.9999999,-0.016835466,-0.040545557,-0.14040285,-0.027913634,0.05000143,0.08540191,-0.046433873,0.015699372,0.029166115,-0.04595689,0.1013126,-0.03881821,-0.100661844,-0.038604517,-0.030559096,-0.0035972674,-0.109621115,-0.014993471,0.027708676,-0.048624344,0.03759121,0.00984849,-0.02601967,0.011162333,-0.017931966,0.000117584874,0.03912352,0.0005446159,-0.028485384,-0.008044491,-0.034493357,-0.0051050643,0.042904787,-0.04708201,-0.0524777,0.08275677,-0.043936595,-0.035532273,0.070934914,-0.03683682,0.0827358,-0.0043620393,-0.016085478,-0.013880128,-0.013499418,-0.07053292,0.031090535,0.004408397,0.09083032,-0.08829049,-0.02250087,-0.0069118156,-0.041053195,0.019333506,-0.042860936,0.0002742718,0.043772552,0.08302935,0.036328193,0.0043272544,0.04772816,0.013195509,-0.015690748,-0.02896752,-0.0034962364,-0.058497105,-0.046628557,-0.0085225925,0.028007861,-0.033996414,-0.037905905,-0.04070936,0.03163717,0.044655595,0.012684794,0.09148662,-0.08502878,0.0036356847,0.0046671666,-0.0116290115,0.010418417,0.056926463,0.025200365,0.12953252,0.019319056,0.033503998,-0.011811141,-0.0060173343,0.034254543,-0.01993531,0.12935913,0.032521386,-0.041995026,0.025820566,-0.052893423,0.07848165,0.0712107,-0.028612688,-0.016791519,-0.038466327,0.030409189,-0.050922472,-0.10610317,-0.07650699,0.01254981,0.110631436,-0.033200663,0.040333156,0.10845337,0.018316928,-0.0643704,0.0018185445,0.039471578,-0.038538333,-0.052611966,0.042277154,-0.045387514,-0.021913437,0.047969226,-0.0040960764,0.041499853,-0.013555471,0.015501862,0.04286642,-0.022475408,0.00011109128,-0.08797978,1.8808745e-33,0.057922628,0.042706497,0.025663763,-0.0020187544,0.060239043,-0.058206677,-0.056005493,-0.051430102,0.020831695,-0.04319402,-0.11531867,-0.0868433,-0.04685702,0.0036585238,-0.056033764,-0.0652132,-0.048437797,0.008187925,0.022938447,0.049200296,-0.024944035,0.031057253,-0.1448108,0.03194401,-0.006378737,0.07421848,0.00062016695,-0.045594495,-0.01329431,-0.0050829323,-0.005920965,-0.020398596,-0.10004583,0.004641089,0.034146335,-0.010301374,0.012414258,-0.039063983,-0.02764811,-0.005820671,-0.033806875,-0.008844385,0.0014819304,0.019109076,0.06715996,0.01342322,-0.041936137,0.03733137,-0.002016584,0.03752929,-0.011049954,-0.028542804,0.12635468,0.078422464,-0.022924652,0.02582075,-0.01843445,0.013570244,0.08705176,0.05538436,0.02626096,0.056779977,-0.009695392,0.013430342,-0.0499897,0.025218042,-0.08066062,-0.03882274,0.06704228,0.07489995,-0.04265696,0.023812665,-0.022048669,0.05716536,0.03136013,0.001850723,-0.0794637,0.01689973,-0.064054996,0.005577133,-0.027698305,0.0054819663,0.064151414,0.035239015,-0.042767785,0.03970364,-0.028312674,-0.023485957,0.0017109851,-0.0053885705,0.100687765,-0.028731508,-0.024869747,0.029420678,-0.034728266,-1.8181158e-33,0.10095124,-0.011889123,0.059712023,-0.068396635,-0.06744817,-0.014890014,-0.0732194,-0.04259136,0.0064002937,-0.013195741,0.037054244,-0.020211138,0.0013747832,-0.023445643,-0.030209234,0.12503792,-0.016445197,0.05926172,-0.023203237,-0.05328168,-0.067282245,0.011320249,-0.052008558,0.087709635,0.05233025,-0.032624163,0.0131737385,0.032398492,0.05647966,-0.001517067,0.027982073,-0.026699381,-0.0035694344,0.0752063,-0.02073857,0.04078342,-0.076373786,0.01748919,0.08774771,0.108443685,0.05472854,-0.01635315,0.020341935,-0.003208606,0.0068468098,-0.012008068,-0.006603706,0.034468617,-0.053126153,-0.03640992,0.08246162,0.019457022,0.069270335,-0.021204952,0.03727258,0.069185905,0.06250355,0.018876562,0.01894242,0.007270886,-0.0061654695,-0.05576306,0.006025763,0.034670725,-0.0028644628,0.019374171,0.00418605,0.034605637,0.052152812,-0.0031619347,0.09980915,0.028119227,0.04419591,0.097774476,-0.04453391,0.0025722801,0.019848986,-0.04737879,-0.01392031,-0.015612951,0.03001683,0.00016612056,0.052267008,-0.11387266,-0.031715352,5.2945925e-05,0.038559034,0.09641389,-0.0057275225,0.056733638,0.030270763,-0.010655699,-0.03918711,0.05667241,0.13992676,-4.5528626e-08,0.03339683,-0.082292415,-0.004198817,-0.07290024,-0.061030548,-0.008283981,0.05383986,-0.0014405483,0.023001753,-0.04245512,-0.01703361,-0.0033593369,-0.07187716,0.020596674,0.004135674,0.050084356,0.04923015,0.063823685,-0.041111488,0.020702234,-0.09707366,6.790387e-05,-0.17642492,-0.024602696,-0.016846143,-0.058159836,0.023787094,0.059339304,0.023279553,0.028965252,-0.013151307,0.024312051,-0.043152362,-0.016817046,-0.083073415,0.08554158,-0.09728709,-0.06533424,-0.019022062,-0.012607672,-0.00030714378,-0.04515779,-0.03207014,-0.062143672,0.035461135,-0.0038597302,0.012835782,0.06147882,0.019090042,-0.048412696,0.078661986,0.02227504,0.05428758,-0.11590996,-0.111095384,0.029564004,-0.016722945,0.05395655,-0.005591883,-0.065459125,-0.08354837,0.06659375,0.17227331,-0.026397314 +4.2.1.140,"The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in Picrophilus torridus [3] and via the branched variant of the Entner-Doudoroff pathway in Sulfolobus solfataricus [1,2]. In vitro it utilizes D-gluconate with 6-10 fold higher catalytic efficiency than D-galactonate [1,3]. It requires Mg2+ for activity [1,2]. cf. EC 4.2.1.6, galactonate dehydratase, and EC 4.2.1.39, gluconate dehydratase. ",384,1.0,-0.013662097,-0.112758644,-0.07414007,-0.012165465,0.011400214,-0.04156584,-0.065569974,0.043723382,0.01777153,0.0023852244,0.013164434,0.034103733,-0.027949624,0.06806436,-0.06018286,-0.0095828045,-0.025818303,0.023891456,0.039008312,0.020241512,0.16188648,-0.017895438,0.0007941541,-0.008065186,0.0860508,-0.037575386,0.041912567,-0.06627455,-0.119081154,-0.013060028,-0.0015354296,-0.023011316,0.04689739,0.0035892348,-0.005612629,0.07961002,-0.04032711,0.020980427,0.012111597,-0.035522915,-0.006118018,-0.033435766,-0.003832647,-0.022730332,-0.04162026,-0.034871764,-0.019235563,0.06520788,0.0011998228,-0.014902925,-0.09112919,-0.033675186,-0.077422224,-0.012174171,0.067638695,0.002589716,0.023034712,-0.023280798,-0.012005057,-0.012116309,0.055327076,0.04157693,-0.0025277098,-0.048661597,0.006153061,-0.095153265,0.041834425,-0.027921576,-0.0024177004,-0.041342713,-0.029446337,-0.04367199,-0.024474138,-0.03132234,-0.019931138,0.062234946,-0.0075206454,-0.017859895,0.042852107,-0.03583015,0.059982337,0.032892503,0.029182367,0.07235896,0.048244108,-0.053827286,0.061602958,0.054647394,0.054158084,-0.040381256,0.020856183,-0.009149554,-0.09018499,0.0009209161,-0.062051345,0.028424691,-0.03939482,0.04099227,0.003776997,-0.04286023,-0.0022168222,-0.02176181,-0.0033081337,-0.04589188,-0.047040693,0.025678687,0.0680832,0.12539136,0.016905237,-0.012437277,0.041999742,-0.0004934002,0.028816646,0.08441079,-0.06692695,0.09578188,0.06152116,-0.060832247,-0.14984925,0.06268212,0.011922142,0.010339705,0.07854607,0.0053066425,-0.023615181,0.04978151,-0.036582313,2.9516805e-33,0.09185179,0.034675546,0.03200172,0.01350403,0.01486279,0.01451356,-0.08333382,0.021798905,-0.034232426,0.071514994,-0.092205055,-0.04178979,0.018474074,0.06533359,-0.08292803,-0.0019088171,0.04873386,-0.010872776,0.05950101,0.007635534,0.025269134,0.07996957,-0.0013592466,-0.036666557,0.059313495,0.04916735,0.006368218,-0.0022707134,0.10501479,0.006005991,0.06185994,-0.180446,-0.06571146,0.03105714,0.05337232,0.025859531,-0.062971845,-0.042345177,-0.010533387,-0.026538853,0.013752974,0.027920455,-0.006290195,-0.07576531,-0.0010598198,0.0385784,0.004099594,0.048672833,0.024982117,0.09219992,0.0954523,-0.049899887,0.04922182,0.016161393,-0.053789727,0.017037759,-0.07187385,-0.015539224,0.078603685,0.070014626,-0.004269858,0.03909095,-0.038146876,-0.0055977493,0.030037237,0.024792314,-0.05694274,0.010111214,-0.03699632,0.02867237,-0.07276196,-0.076308675,-0.0063756793,0.030116243,-0.020093083,-0.022031663,0.02996134,0.008677705,-0.008560605,-0.043324795,-0.025835445,0.02357993,-0.025290396,0.032011133,-0.026927812,0.057200365,-0.08252407,0.0029579771,-0.034996826,0.03278479,-0.024932401,0.0088656945,-0.09167071,0.017144281,0.039258335,-3.468644e-33,0.06643454,-0.10153908,0.075507574,-0.09937333,-0.042131193,0.10295963,0.03550372,-0.062034857,0.060305327,-0.062276416,0.036360364,0.019177565,-0.011659763,-0.08104097,-0.057163592,0.016619837,0.017403923,0.027823245,-0.08921471,-0.042325135,0.0023664695,0.1341422,-0.007952539,-0.027905699,0.027398704,0.030715467,0.061004564,0.073983796,0.0018660695,0.012725469,0.07112692,0.0041942764,-0.033507835,-0.1153213,-0.046624303,0.09449874,-0.06282472,-0.017395511,-0.007892281,0.05393686,-0.045510888,0.021764344,0.06159441,0.041738212,0.04116777,0.027886746,-0.10336816,-0.007863536,0.050461885,-0.0154167535,0.0635631,-0.06315619,-0.009875436,0.011930812,0.054323792,0.011585606,0.04965772,0.041890435,-0.061595637,-0.037594046,-0.0034270785,-0.020224389,0.04133158,-0.079530776,0.025121244,0.024547383,-0.033985373,-0.004248965,0.023237364,0.0059110126,0.006699589,-0.03860987,-0.06412329,0.038269363,-0.01290238,0.028689746,-0.10846091,-0.0008510168,0.009010202,-0.023604425,0.022176856,0.02427773,0.008389252,-0.024233872,-0.0042838682,-0.0843395,0.0635135,0.10846758,0.033582117,0.005811497,-0.06646971,-0.050731674,0.010447243,0.0165215,0.06547427,-4.3982325e-08,0.023690138,-0.015034745,0.015467494,-0.057982534,-0.09412458,0.0070568505,-0.0098935515,0.02148994,0.041246768,-0.03136346,0.0538546,0.11106229,-0.011935264,0.027906863,0.0083858045,0.009942141,0.023149122,-0.033399608,-0.035991084,-0.013407646,-0.038463064,-0.031507656,-0.17975236,0.01567036,0.054173853,-0.09461751,0.029722022,0.007650473,-0.043621145,-0.069555,0.101508126,0.05443969,0.021249965,-0.006166573,-0.052575935,0.0065664356,-0.07470944,-0.0039642504,0.03688289,0.03374719,0.04249243,0.011697313,0.011046709,-0.004347607,-0.10784881,0.038599133,-0.03129483,0.06968069,-0.044509403,0.09843398,-0.017727572,0.05648635,-0.08127038,-0.055215683,-0.06258352,-0.005295812,0.040075313,-0.035635795,0.022145731,-0.06599762,0.045583602,-0.05603384,0.107718736,-0.030645013 +4.2.1.141,The enzyme participates in pentose oxidation pathways that convert pentose sugars to the tricarboxylic acid cycle intermediate 2-oxoglutarate.,384,1.0,0.011091419,-0.07927948,-0.03328263,0.01652481,0.00644267,-0.0019658967,-0.03410292,-0.06091013,0.042443145,-0.0014089209,0.022442004,0.024109716,-0.10382149,-0.004782099,0.00035128393,0.03319154,-0.11060705,-0.040356874,0.025036318,-0.034179196,0.17311703,-0.047101412,-0.015119717,-0.06445717,0.021779753,-0.0008277563,0.036369286,-0.055349097,-0.05860521,-0.098450616,-0.042758502,-0.052636515,-0.048963338,-0.045655858,0.04488034,0.036597412,0.017390588,-0.03296448,0.048433356,0.031576633,0.017005045,-0.0052268836,0.003118019,-0.009658472,-0.022922192,-0.060706254,-0.0029274344,0.011973053,-0.02669302,0.06046646,-0.038680173,-0.08002726,0.031058105,-0.026621014,0.0445705,0.027574986,0.05761003,0.057844177,-0.02445226,-0.028915102,0.06737448,0.025437655,-0.031458385,0.033841047,-0.016905343,-0.13108687,0.078162745,-0.046860542,-0.04925814,-0.09501422,-0.113112636,-0.024692966,-0.0378706,-0.07255563,0.028987994,-0.053387236,-0.013992726,-0.05853036,0.059556536,0.043828253,0.054232925,0.03719108,0.05369739,0.080258496,0.012767164,-0.05407439,0.012543923,0.001335959,-0.015606793,-0.0062321196,-0.016723368,-0.029766254,0.007042493,0.036542393,-0.032103844,0.03298223,-0.001095604,0.037588075,0.0070150956,-0.027813654,0.008415391,0.032535885,-0.010349571,-0.105743855,-0.022332197,0.06324556,-0.06844322,0.06763543,0.051791754,0.0287079,0.06555988,0.044993196,0.10904281,0.052244894,-0.029697089,0.11541928,-0.05748906,-0.048840206,0.06501198,0.06078063,0.020486737,0.008035518,0.029888282,0.116364256,-0.027950859,0.016380213,-0.037693374,1.7071293e-33,0.047290996,-0.011013164,0.009749057,-0.002521537,0.008645875,0.0014167317,-0.056997728,-0.025141625,-0.045199007,0.016081158,-0.0393259,-0.043440323,0.046617188,-0.004928259,-0.04751882,0.004750176,-0.043111335,-0.0042022914,0.048708353,0.06761247,-0.04806607,0.0386135,-0.07092147,0.025020627,0.034003142,0.0964206,-0.0231615,-0.009140714,0.017831346,0.017254753,0.08104603,-0.029802326,-0.02880444,0.02225046,0.058774825,-0.0641393,0.027923949,0.0007775907,-0.02023168,0.05552436,0.013344235,-0.026492057,0.03471863,-0.061830144,0.044730328,-0.027970906,-0.042038962,0.10517628,0.038708944,0.08529016,-0.021268303,-0.0047112433,0.040348843,0.07294217,-0.047222696,-0.00054223137,-0.057088498,-0.05497194,0.10298175,0.027823312,0.015447872,0.051286027,-0.054840054,-0.007348774,-0.04551146,0.016641857,-0.023015236,-0.010395568,-0.013512644,0.109413765,-0.08926379,-0.031030415,0.04003064,-0.00026659406,0.03528734,-0.05185547,-0.0074729,0.051817022,0.01703215,0.006377382,0.025287775,-0.058203172,0.0012794888,-0.07800076,-0.09314003,-0.0536663,-0.04124026,0.025045648,-0.030971909,0.060856182,0.0047270977,0.006301832,-0.068093486,0.02942532,0.049110353,-3.4604063e-33,0.13861774,-0.097008355,0.00999156,-0.10653519,-0.04494164,-0.009126961,0.036678404,-0.0880443,0.03449363,0.008562791,0.046042804,0.037193265,-0.008198368,0.03214745,0.051703993,-0.024291815,-0.03611965,0.06207154,-0.019631531,-0.008184315,0.03638845,0.14349742,-0.015984531,0.011161789,0.072999686,-0.03517805,-0.020618029,0.018587055,0.050384607,0.038993724,-0.038442716,-0.09129322,0.052597664,0.0027397526,-0.059252426,0.023811726,-0.06721784,-0.055745173,-0.036575135,0.10539345,-0.013785568,0.0035896287,-0.047991354,0.03458182,0.040948007,0.0319963,-0.11778817,0.018545333,-0.0021440326,-0.076071374,0.050195564,0.022196233,-0.014755451,0.018262492,0.015687771,0.07564139,-0.029441051,-0.05386516,-0.008057153,-0.013784499,-0.08737565,-0.028643928,0.067105055,-0.07275643,0.015089726,-0.010167259,-0.046365198,0.057496052,-0.00043079036,0.04555538,-0.013703298,0.06539184,0.04452805,0.008519648,-0.020348983,-0.039245717,-0.13118717,-0.057586487,0.021810861,-0.08331237,-0.06602891,0.009692104,0.012983622,-0.013044046,0.0178157,-0.054603536,-0.014122472,0.077190526,0.00091275823,0.023060644,-0.048550665,-0.02562007,0.01344563,0.028051259,0.04891976,-2.7299906e-08,-0.03497475,0.023907596,0.08411748,0.008072389,0.030096613,0.030163864,0.09514417,0.053748935,0.017399099,0.00013436652,0.021932619,0.13208258,0.04917209,-0.015435856,2.1786673e-05,0.06243258,-0.015179849,-0.032277036,0.006036666,0.040248584,-0.07016367,-0.039050587,-0.10067522,0.04397234,-0.04453928,-0.030988825,0.06487571,0.07090225,-0.032281432,-0.046398718,-0.019838579,0.043433275,0.015905954,-0.043722216,-0.13214432,0.026021859,-0.022691723,-0.024601623,-0.025360508,-0.037440404,0.0043656025,-0.05751274,-0.05025675,-0.04546212,0.004220868,0.007691885,0.009765885,-0.044916254,-0.0072100335,0.032429248,-0.00043394268,0.025445357,-0.063767634,0.064925864,-0.009075338,-0.019356601,-0.014847812,-0.018535381,-0.0030388779,0.03587206,0.05551276,0.0648073,0.21787225,-0.10382817 +4.2.1.142,"Isolated from the aflatoxin-producing mold Aspergillus parasiticus. The enzyme also catalyses the conversion of versiconal to versicolorin B (EC 4.2.1.143, versicolorin B synthase). Involved in aflatoxin biosynthesis. ",384,1.0,-0.012665022,0.013028692,-0.13581328,0.015449628,0.09925366,0.03961568,-0.10292087,0.055349838,0.0018476115,-0.08442456,-0.014707943,-0.101448655,-0.03677219,0.048680887,-0.08576767,0.04660065,-0.04041327,0.030519908,-0.012715135,-0.048777852,0.01885724,0.0655066,-0.024505677,0.03147624,0.028560571,-0.031741977,0.028029472,0.023116626,-0.0015766271,-0.07317558,-0.046681296,-0.04114153,0.004357268,-0.08269755,0.069273435,0.004048184,-0.01506669,0.040595464,0.11424601,-0.03510672,-0.019980533,-0.051728252,0.010622887,-0.07012967,-0.07678709,0.0331547,-0.019134818,0.01517642,0.020305304,0.0052636755,-0.055966288,0.0036848506,-0.062222954,0.007066369,0.10593158,-0.026306728,-0.008530395,-0.06672576,-0.02176511,0.05179213,0.026019,-0.04181487,0.030806573,0.008881179,-0.053259604,0.0156302,-0.037916146,0.017436024,-0.0070069786,-0.07990717,0.044177663,-0.07661885,-0.0037755969,-0.008545597,0.047596246,0.02818367,0.009204971,0.029564112,0.061510354,-0.005755178,0.089866094,0.0031915277,0.04926918,0.10757085,0.0057687536,-0.032321863,-0.034031127,0.018514339,0.013860604,0.08330958,0.032114457,0.033642653,0.006538352,-0.0072992947,0.04525831,-0.00027540582,0.012605998,0.051129866,0.05812512,-0.01201879,-0.023817588,-0.030571455,0.011022676,-0.04794885,0.02543611,0.0128349,0.00480858,0.03687515,0.07322164,-0.0004335595,0.044892393,0.042437486,0.026525231,-0.050971705,0.018210234,-0.037054483,0.049427167,-0.04585715,0.028849881,0.018526992,0.05228367,0.03071965,0.009401355,0.03437243,0.11744122,-0.04030088,-0.0756245,3.2079858e-33,-0.0064578224,0.057544373,-0.055449355,0.031864885,0.064937405,-0.03250492,0.020088784,0.041083686,-0.049102664,0.034893364,-0.07655924,-0.04091935,-0.08850442,0.020169253,0.040577397,-0.058413967,0.041961294,-0.07777346,-0.0069610355,-0.031610202,0.02524344,0.03761781,-0.10075357,-0.010639441,-0.03035739,0.06435827,-3.0664945e-05,-0.03736145,0.019178556,-0.011685646,0.077126995,-0.013069133,-0.095652625,-0.017874124,0.03913777,0.04704754,-0.027474862,0.0037446523,-0.09121497,0.036972128,0.04003033,0.043565106,-0.07086384,-0.1009212,0.093948334,-0.0012279851,-0.111300245,0.06775575,0.06957653,-0.0078790095,0.09904983,-0.019340046,0.024547955,-0.03476138,0.022761997,-0.05842406,-0.07602413,-0.020216493,0.017018195,0.07134889,0.04783479,-0.003151908,-0.036248904,0.011718581,0.053672824,-0.03496831,0.035686072,-0.06520742,-0.039513744,-0.07336781,0.033281922,0.033555828,0.0068954965,-0.06977023,-0.03650934,-0.026777709,-0.056916412,-0.013107112,0.009472912,-0.04483316,0.022493793,0.03759239,0.019381335,-0.019259924,-0.091118746,0.03517563,-0.015244594,-0.011150707,0.032848023,0.048133437,0.015808143,-0.117509365,-0.10106134,0.08003563,-0.046332978,-3.4390586e-33,0.040254507,-0.08773137,0.057556484,-0.03683937,-0.087033674,0.022614045,-0.022828145,0.050490238,0.039069258,0.0354476,0.027642027,-0.009162452,0.036360912,-0.03468306,-0.02127656,0.030751586,-0.022712335,0.09516157,0.003605108,-0.01742067,-0.09579574,0.051328216,0.0015612931,0.029356312,0.017631382,0.07939537,0.015571003,0.078519635,0.00408655,0.016184434,-0.06666994,-0.019715047,0.022879317,-0.020439481,-0.088953614,0.059541114,-0.057399984,0.023846101,0.031232182,0.016222099,-0.017638419,0.08512856,-0.07047351,0.049656793,-0.0013697215,0.043071385,0.019475086,-0.032554567,0.11358052,-0.055151798,0.08674334,0.006127946,-0.010119589,-0.049138445,-0.038165443,-0.0025494376,0.04184785,-0.03416476,0.016824024,-0.028527329,-0.01135235,-0.016312897,-0.009708483,0.0025213307,0.09259253,0.12823537,-0.07002256,0.0030668166,0.017683899,-0.021931548,0.091024846,0.010097836,-0.0013378592,0.08487661,0.013959218,0.004762753,-0.008080135,-0.062256284,-0.04319415,0.028502079,-0.0077151717,-0.045182925,0.05941085,0.008527723,-0.06579861,-0.13793512,0.11047421,0.057891697,-0.03690178,-0.01382066,0.018427037,0.08894192,0.020343894,0.05150228,0.10227181,-3.0731904e-08,0.03974718,-0.01726494,-0.03579607,-0.016588425,-0.0012812964,0.04427424,0.030317055,-0.012751641,-0.011571365,0.014561612,-0.12799266,0.04896992,-0.05077301,0.010577209,0.058763634,0.013800403,-0.022735242,-0.013916144,0.031590726,-0.046777263,-0.05603937,0.040792365,-0.034224555,-0.048982456,-0.065932594,-0.04853207,-0.019426499,-0.0048042727,0.13802586,0.042140327,-0.036829785,0.05676085,0.012542742,-0.07773186,-0.0838599,-0.033894375,-0.09044641,-0.0887461,-0.016899258,-0.03653074,0.0020632606,-0.0598765,-0.038420387,-0.030276341,-0.06996941,-0.044027857,-0.047649544,-0.017112436,0.0016606174,-0.019971056,0.14527242,-0.012818233,0.068815984,-0.053303167,-0.06966286,0.0064345864,0.009440046,0.053726282,0.01684573,-0.030393103,-0.07586313,0.0425195,0.12399715,0.009543424 +4.2.1.143,Isolated from the aflatoxin-producing mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis.,384,0.99999994,0.019020865,0.035016693,-0.12790005,0.073092744,0.04926006,0.01640499,-0.1034489,0.056748826,-0.0005610228,-0.07539881,0.008811699,-0.06561107,-0.023086669,0.021808019,-0.10337556,-0.019200973,0.027386649,0.0048599,-0.017883167,-0.024388934,0.050811518,0.06661863,-0.035639502,-0.00029337752,0.020124074,-0.024127768,0.058269322,-0.001881765,-0.025016632,-0.08438709,-0.05429053,-0.064874195,0.012601006,-0.06408256,0.08964901,0.039299224,0.012454378,0.024617711,0.13735637,-0.026701454,-0.039958864,-0.036138747,0.008388982,-0.056555014,-0.09338062,0.021835765,-0.060037233,0.033159696,0.045635533,0.0065207533,-0.073701896,0.02999112,-0.008667942,0.036935754,0.12285326,0.003155716,0.014314389,-0.06561435,-0.061018817,0.027132045,0.000706442,-0.011939518,-0.009038066,0.024952913,-0.09456026,0.014465587,-0.032995325,-0.008329958,-0.03707068,-0.07151974,0.0100627495,-0.03990317,0.06719936,-0.017404042,0.116249405,0.029487638,-0.014412642,-0.017144844,0.06844024,0.010643801,0.081712276,0.04020375,0.057832535,0.029243302,0.006584958,-0.03118376,-0.0053241802,0.08440959,0.014063492,0.092348844,-0.00026691996,0.065898314,0.05935595,0.006855269,0.01576231,0.0063192337,0.08197266,0.08020991,0.0007529459,-0.040911738,-0.02507482,-0.032050714,-0.00090770784,-0.014552945,0.048490673,-0.0085780965,-0.022280931,0.0026351288,0.06946404,0.024363225,0.040975507,0.022637112,-0.068451144,-0.08963315,0.034969907,-0.03282503,0.06459967,-0.044243515,-0.030313276,0.026056085,0.05621528,0.031979,0.0059038615,0.037211798,0.082158715,-0.022361014,-0.05100533,3.1752077e-34,-0.019026345,0.04998592,-0.08707037,-0.005574833,0.07629307,-0.0814129,0.050918765,-0.029479442,-0.025059743,0.068653755,-0.0779371,-0.036654595,-0.13048679,0.0033890419,0.033554535,-0.01326362,-0.016187211,-0.05480625,-0.0006312015,0.011574456,0.009473073,0.02131866,-0.061162166,0.04281803,-0.008645144,0.033278827,-0.007426177,-0.033998005,-0.012303613,-0.0071517564,0.052925203,-0.03293096,-0.10149906,-0.037108604,0.085949086,0.021919297,0.0034651826,-0.01366517,-0.1295907,0.0020062348,0.0076652607,0.032954052,-0.023959119,-0.10882858,0.033650424,0.003595084,-0.08948766,0.025438292,0.08302646,-0.014151748,0.09866734,0.012006799,0.07737007,0.014836182,0.016010206,-0.055509396,-0.08342864,-0.007752676,0.051828276,0.049232017,0.04169302,-0.02906519,-0.02260862,0.060042355,0.02872426,-0.016159495,0.039215427,0.006839141,-0.009167792,-0.0115686795,0.029248461,-0.0367817,-0.044815138,-0.041088928,-0.029995766,-0.003579797,-0.06826464,-0.032941166,-0.0012091869,-0.03495467,0.047893435,-0.0015524527,-0.015262238,-0.030423766,-0.08870887,0.055278227,-0.017924806,0.047927994,0.024861006,0.039339405,-0.0048580645,-0.029388895,-0.041697126,0.053098816,-0.01956748,-2.306415e-33,0.08586285,-0.0794292,0.03231715,-0.0616837,-0.117351666,0.07081054,-0.024261614,0.05663141,0.016756782,0.022683183,-0.004960677,-0.0063666403,-0.015308678,-0.022711119,-0.052001692,0.05296068,0.003127958,0.11416323,0.05748611,-0.011506243,-0.069361076,0.05771896,-0.08460099,-0.010297441,-0.0050103143,0.051612947,-0.014379154,0.082721025,0.011378051,0.022872616,-0.01907977,0.04671471,0.04444789,-0.022231935,-0.090667315,0.08484011,-0.0584589,0.025218604,0.02437575,0.038351525,-0.029327298,0.03509157,-0.04714972,0.046308644,0.040434476,0.04035271,0.01927453,-0.018204058,0.056682028,-0.011372106,0.04569434,0.009824658,-0.011587229,-0.06798214,-0.05635619,-0.02008019,0.018263264,-0.003206662,0.08184945,-0.044975236,-0.0037701514,0.010378671,-0.04280345,-0.009894833,0.09541485,0.083419584,-0.07269763,-0.0530935,0.01497058,0.009931427,0.019821975,0.020338783,-0.010744464,0.07409386,-2.7964968e-05,0.0065633995,-0.015764754,-0.0025023385,0.016391832,0.08114842,0.028383221,-0.0019070783,0.09008159,0.030319633,-0.07143955,-0.121111825,0.11497021,0.02744589,-0.0735547,-0.0053594843,0.016202617,0.0642778,-0.0032013077,-0.0029769314,0.04452721,-2.2650026e-08,0.049735915,0.01819507,-0.026013218,-0.08344561,0.0075561185,0.026048724,0.009748663,-0.03349694,0.015373668,-0.04644374,-0.11194303,0.01786601,-0.029488761,0.062178284,0.054905016,-0.020476632,-0.041788522,0.005041202,0.03104637,-0.02002185,-0.07725979,0.028131777,-0.044391766,-0.042271473,-0.06878269,0.007261573,0.02617393,-0.019600092,0.09867933,0.05866311,-0.06975503,0.076826274,0.015913386,-0.12354181,-0.10019558,-0.033187855,-0.094476864,-0.08660658,-0.006237388,-0.06831219,-0.022210058,-0.07314833,-0.0070839925,-0.059602864,-0.07327073,-0.03294035,-0.016711872,-0.03293201,-0.010200801,-0.0046543237,0.11254104,-0.004289033,0.04478715,-0.06255264,-0.058017597,7.213144e-05,0.06878616,0.0101106325,-0.023700284,-0.08932537,-0.077942334,0.011612803,0.14529714,0.012179621 +4.2.1.144,"A pyridoxal 5'-phosphate enzyme. The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-alpha-D-kanosamine [3]. ",384,1.0,-0.059438195,-0.045741558,-0.08700766,-0.07243101,0.031677306,0.0073780837,-0.051347114,0.0055889776,0.039992936,0.042181954,-0.0133076655,0.016073426,-0.0036502734,0.046430565,-0.027012335,0.045551766,-0.13835174,0.027982881,0.012857718,-0.024719086,0.09464085,0.026159413,0.04540061,-0.018838929,0.07027825,0.023172623,0.08941264,0.019743454,0.00058367255,-0.0696488,-0.00012378665,-0.02523859,-0.008825443,-0.0780444,0.057019684,0.11002602,-0.086222194,-0.00610935,0.05762984,0.0062356843,0.039892104,-0.07959181,-0.025846867,0.05636534,-0.03969771,-0.052082065,-0.012914254,0.04768389,0.040737543,-0.058233913,-0.09273749,-0.017833792,-0.00905783,0.0040761707,0.008729641,0.070271626,0.024729347,-0.03336204,-0.027304728,-0.027981328,0.030661631,-0.015768653,0.059686366,-0.038593788,-0.009395982,-0.045947514,-0.00954653,-0.07580399,0.005097263,-0.011724331,-0.07285709,-0.023025934,0.002171363,0.0005089028,0.024044646,-0.020326674,-0.024989888,0.026396206,-0.0323235,-0.043457136,0.028228158,-0.030050665,0.0903244,0.086544834,0.059010316,-0.04903669,0.081242904,-0.007003806,0.031028785,0.06068025,0.036462482,-0.010590204,-0.026754772,-0.025229495,-0.103586584,-0.0016957136,-0.051606175,-0.023023665,0.040629055,-0.044556342,-0.010693197,0.028610444,-0.0356811,-0.08552815,-0.05033779,0.036659583,-0.040476926,0.03206971,0.012041399,-0.018011218,-0.015285642,0.026949983,-0.01669334,0.043332044,-0.0035997054,0.039208494,0.041118767,-0.07055401,-0.066301435,0.018927945,0.00032448178,-0.026273279,0.029339718,0.048915353,-0.07485633,0.03874025,-0.12644814,1.2940647e-33,0.0331839,0.0753263,-0.055135563,-0.03138093,0.031756688,-0.016033372,-0.07581074,-0.028267534,-0.108158454,-0.0636609,-0.08958796,-0.05010167,0.019661397,0.042397354,-0.023410415,0.000126256,-0.021646716,0.021374052,0.05109642,-0.012312394,0.07164816,0.06967092,-0.05642001,0.006280258,0.04597083,0.08535532,-0.028349526,0.06916264,0.06052578,0.0023888408,0.027796818,-0.09194523,-0.11048937,-0.05857075,0.073705494,-0.00085748325,0.0009892792,-0.009324919,-0.024914239,0.032057863,0.00016072326,-0.028910344,-0.015505358,0.0042488584,0.02575727,-0.03563389,-0.01527892,0.09592084,0.05739399,0.08033844,0.04013524,-0.041494675,0.09855881,-0.043668702,-0.10067802,-0.0087965755,-0.0149024995,-0.049612775,0.035770804,0.03618596,0.030729245,-0.0051158275,-0.043672454,0.0061928486,-0.028792173,0.008414529,0.040237874,-0.058178872,0.031359144,0.04931138,-0.04028608,-0.026052434,0.053902198,0.029086623,-0.013559561,-0.01759302,-0.07212159,-0.011441828,0.049710132,0.0031613763,-0.060060225,-0.018583579,-0.032149136,-0.053795192,0.013274894,-0.005933651,-0.02744444,-0.06568048,-0.030662676,0.03345543,0.025333786,-0.0806386,-0.038815223,0.06958683,-0.008526194,-2.314564e-33,0.12295257,-0.108580984,0.06867218,-0.05726947,-0.02015748,0.026436351,0.06890941,0.0059451493,0.050763145,-0.0074150697,0.06269334,-0.012131322,-0.031420954,-0.011851475,0.012760989,-0.015384376,0.04054015,0.088916734,0.024377124,0.016821917,-0.010416478,0.11621023,-0.036745455,0.039016824,0.0020435883,0.08783015,0.014858852,0.03481502,-0.0020761893,0.024388481,-0.028042573,0.008733144,-0.034237552,-0.046065547,-0.09126937,0.049794946,-0.05975337,-0.011980042,-0.006013296,0.011116901,0.04247896,0.079713695,0.004106325,0.047377165,0.0004626979,0.009418095,-0.05719237,0.025721004,-0.034007024,-0.06911907,0.06936158,0.03859269,0.07562162,0.040243823,-0.013440391,0.027805645,-0.025470955,0.027587172,-0.00010227744,-0.013171169,-0.027680457,-0.07111092,0.06370147,0.039155073,0.06321619,0.07552931,0.020105056,0.06749967,0.028731808,-0.032301314,0.035344,0.076957054,0.03830743,0.10941585,-0.036496278,0.0075715096,-0.09044951,-0.013366966,0.062076796,0.0072329678,-0.014702461,0.0016659591,-0.057881873,-0.09238997,-0.073457204,-0.06887895,0.083633676,0.0900544,0.08526905,-0.020645257,0.029677777,-0.016025927,-0.02919654,0.076152526,0.08934594,-3.7777344e-08,0.042830177,-0.038960416,0.012220754,-0.06860252,0.055835057,-0.040661752,0.007900336,-0.031026486,0.061284106,0.0046916516,-0.01158671,0.10311434,0.015587814,0.002191022,0.032418083,0.05776587,0.0061715473,0.028776325,0.0028676516,-0.04923956,-0.05765347,0.023619564,-0.13462369,0.052550465,0.10288416,-0.051469393,-0.049576577,-0.003735502,-0.03399477,-0.0040866695,0.0094581265,0.0022375458,-0.0071667987,-0.019885452,-0.052023984,0.058162186,-0.04414777,-0.08345858,0.01945267,0.010941357,0.031840473,-0.05723482,-0.031859487,-0.035908114,-0.062826015,0.043581013,-0.05188166,-0.016315047,-0.033462733,-0.03778256,0.05655554,-0.018532123,-0.049415555,-0.08037427,-0.15224163,0.044419818,-0.021796724,-0.05198886,-0.02310505,-0.10329634,0.022603886,0.03493496,0.2107793,-0.07781427 +4.2.3.143,"Isolated from the root of the plant Thapsia garganica. The enzyme also produces germacrene D, bicyclogermacrene and traces of other sesquiterpenoids. See EC 4.2.3.77, (+)-germacrene D synthase and EC 4.2.3.100, bicyclogermacrene synthase. ",384,1.0,-0.040267453,-0.0016313114,-0.13330518,0.03232355,0.026837267,0.016158976,-0.012158571,0.051027607,0.052769814,-0.023205722,0.06050542,-0.013966742,-0.003507336,-0.08251094,-0.056245428,0.020703997,-0.011908905,0.008084631,-0.0104557285,-0.051181104,0.06091215,0.025639042,-0.017869143,0.030479392,0.08601963,-0.0068202373,0.042852856,-0.025984842,-0.0030110893,-0.04639965,-0.03328716,0.029807761,0.04096952,-0.10440762,0.055048037,0.032728743,-0.01691945,0.010536572,0.08821347,0.055642974,0.04709668,0.002746517,0.022072494,-0.028761784,-0.06761383,0.011005724,-0.038991842,0.07618735,-0.044095594,-0.024612848,-0.04682617,-0.020090284,-0.0652101,0.03972203,-0.03250532,-0.046312798,-0.022521669,-0.024181804,0.013044342,0.07311897,0.050133944,0.070328996,0.058991294,-0.036563747,-0.007406093,0.022820232,0.0071645873,-0.031186044,0.07503762,-0.055087883,-0.061340094,-0.061975688,-0.0292072,-0.018706648,-0.051494673,-0.0029951609,0.036388133,0.008350501,0.045791317,0.023949109,0.008813019,0.03819984,0.07981212,0.09155192,0.021627853,0.026056085,-0.015770333,0.1129163,0.043943577,0.012383316,0.056163218,0.030430399,0.025641311,-0.054381534,-0.05330391,0.02970331,-0.008829631,0.0044396953,0.01500988,-0.041189123,0.046714675,-0.0006772418,0.0117670195,-0.102024555,-0.1108619,0.06222904,-0.045371093,-0.07291331,0.06617128,-0.03511466,-0.05735952,-0.0020763592,-0.024852104,-0.0060591325,-0.039139338,0.08082946,0.035698976,-0.06273035,-0.016705489,0.03166792,-0.007617265,0.0138816545,0.072977886,0.034175366,0.030252196,0.0626536,-0.10369841,4.0238343e-33,0.07160798,0.016880509,0.03820874,-0.019738648,0.0029362508,0.017029632,0.017500749,0.070548184,-0.10575908,-0.06329594,-0.10157556,-0.10305152,-0.011248139,-0.0041503585,-0.049223904,0.061381467,-0.0055449023,-0.060084417,0.04361838,-0.023042398,-0.0008246334,0.04442229,-0.033055577,0.02883488,0.01899393,0.0751891,-0.04737655,0.024891568,0.08738305,-0.023701694,0.03169485,-0.11188035,-0.08258624,0.00154216,0.02282684,0.052884888,-0.05248419,-0.017277159,-0.07314237,0.08702952,0.011890077,0.07051517,0.07021117,-0.047502507,0.037553273,0.04904307,-0.09214471,0.02255224,0.14420351,0.01696725,-0.005539919,0.021745348,0.027251087,-0.028829755,-0.06635003,-0.017128227,-0.05518518,0.027569707,0.08313037,0.028710855,-0.0014682338,0.044909395,-0.027063677,-0.0259223,0.012501966,0.10833934,-0.12615721,-0.060921613,-0.080242984,0.041696057,-0.03804368,-0.09691463,0.05060269,-0.051873844,0.028042665,-0.02448462,-0.07571102,-0.031023666,0.013184287,0.0103520015,-0.036259342,-0.038391564,-0.031673256,-0.036330447,-0.03225624,-0.08784211,-0.049201634,0.022942645,0.009435381,0.06634452,-0.011732352,-0.044053674,-0.10665053,-0.0040046005,0.027286768,-3.7405784e-33,0.03262466,-0.06405133,-0.006193924,-0.056530513,-0.03000293,0.054025274,-0.022185901,-0.07706843,0.01716388,0.025667606,0.07763584,-0.021977935,0.051245373,-0.01975012,-0.011443088,-0.010377467,0.07353125,0.12244489,0.035146624,-0.0037912389,-0.04281434,0.027799241,-0.015308618,-0.025323974,0.0001806175,0.015670452,0.03643066,0.016977394,0.051712304,0.0065187723,-0.04497747,0.001999671,-0.08759329,-0.029502869,-0.09744974,0.033090524,-0.1148069,-0.030161023,-0.011536562,0.017966976,-0.0717255,0.006162447,0.08996899,0.18167144,0.098361984,0.0086293835,-0.04659962,0.0073164245,-0.025208209,0.02932025,0.0738819,0.022651482,-0.048270483,0.018515715,0.03423125,0.034437984,0.030644817,0.067150004,-0.025590083,-0.08850501,0.00031214248,-0.031650506,-0.07300176,-0.07230474,0.09237347,0.09360912,-0.0029850276,0.05551653,-0.0034555236,0.0043575056,0.09214551,0.017017543,-6.4996435e-05,-0.022978535,-0.034441102,0.011168352,-0.06964799,-0.026893653,0.02428692,-0.035684936,0.037355114,-0.033961985,0.022604933,-0.009837421,-0.02814889,-0.06955884,0.044547293,0.06624339,0.072151214,0.032357562,-0.03707811,0.001281638,-0.08114618,0.106393196,0.112846,-3.5534192e-08,-0.0048422758,-0.020102382,-0.043884456,0.012154568,0.0431488,-0.017015843,0.013009209,0.03757225,-0.0057236827,0.053884376,-0.027847338,0.033100188,0.007446157,0.0061534867,0.14452395,-0.03646036,0.036954537,0.062739395,-4.3461725e-05,-0.00027016574,-0.0057268287,-0.011270553,-0.059021555,0.0027650255,-0.04155662,-0.09393583,0.068517774,-0.061751407,0.06621307,-0.0154608125,-0.0028305552,0.023123162,0.052241184,-0.025838258,-0.04412678,-0.031079855,-0.06771224,-0.0065109264,-0.005386438,-0.005942997,-0.03809716,-0.04125738,-0.043663807,-0.0036464632,-0.027593803,-0.0026635167,0.01314731,-0.016717508,0.018559456,0.042647094,-0.015415351,-0.0587386,0.029352957,-0.017302753,-0.008765605,0.004268988,0.015208653,-0.060322303,-0.03300305,-0.05982201,-0.07277015,0.0076689627,0.1581383,0.046335164 +4.2.99.22,Isolated from the plant Tulipa gesneriana (tulip). The reaction is an intramolecular transesterification producing the lactone. The enzyme also has a weak activity with 6-tuliposide B and 6-O-benzoyl-D-glucose.,384,1.0,-0.015460219,-0.047268838,-0.11496969,0.011376018,0.056060094,0.06325294,-0.073678106,0.015257746,0.0027506598,-0.05208444,0.08411713,-0.03859713,-0.15288833,-0.08531451,-0.009926991,0.086987585,0.008951019,0.05525302,-0.0059937113,-0.06665735,-0.00730306,0.049624298,0.04085705,0.08560861,0.09477055,-0.09165395,0.029344797,0.020971565,-0.04010249,-0.0872601,-0.05110735,-0.03517673,0.023358678,0.014962622,0.012806987,0.11328437,-0.020191107,-0.048787665,0.119760886,-0.020448646,0.059847444,-0.0710149,0.044548284,-0.016404748,-0.01010954,-0.0227128,-0.058723938,0.03255144,0.027327975,-0.033350978,-0.09375261,-0.060506444,-0.037631374,-0.02238274,-0.0072273263,0.053159337,0.03235503,-0.062173713,-0.005608509,0.058287855,0.057046678,0.008274495,-0.03510009,0.016091218,-0.09017028,-0.042514235,0.035465255,-0.0109746475,0.10938457,0.008665898,-0.022939013,-0.083788,-0.0034945542,0.004110012,-0.058522455,-0.0036046738,-0.0025140606,0.02162596,0.07728794,0.041637048,0.05027837,0.006078791,0.032442357,0.018686378,0.016767783,-0.049987048,0.034870747,0.09547267,0.07163214,0.035922322,-0.021951297,0.079929814,-0.04298383,-0.039040323,-0.07975537,-0.029212005,0.049188584,-0.032720827,0.019591833,0.016573094,0.05409212,0.010993899,0.08464563,-0.070137165,-0.0644371,0.04431203,0.013528535,-0.010621708,0.01235333,0.017205779,-0.04609425,-0.02832049,0.015654426,-0.02736162,-0.051923864,0.07103642,0.0075741573,-0.075369135,-0.005465366,0.045262784,0.00790692,0.0122115025,0.080721475,-0.00878695,-0.029111797,0.052730802,-0.053690016,-4.84387e-34,0.07551209,0.048118003,0.0293875,0.015188657,0.0135104805,0.012535298,-0.04848186,-0.017392315,-0.13893045,-0.0112382425,-0.041061983,-0.091710225,-0.007440737,0.040141605,0.03581269,0.012217694,0.04956044,-0.006915381,0.03626454,-0.049019087,-0.07192114,0.038413204,-0.10222138,0.024445057,-0.03224006,-0.0029647711,-0.02368334,0.009952906,0.018338334,0.015109896,0.1042914,-0.037865106,-0.01350009,0.0603239,0.018327912,0.018991355,-0.093941405,-0.03997832,0.048404343,0.101644,0.053817194,0.045212585,0.09262832,-0.018377865,-0.011346921,0.046328597,-0.041266423,0.029578771,0.09376012,0.0078473035,0.034252226,-0.010175561,0.021380503,0.030742507,0.03410873,0.0031723075,-0.035050128,0.1179017,0.08018405,0.005338019,-0.027056174,0.037567195,-0.005415325,0.0052505974,0.0012000978,0.04778733,-0.12504455,-0.058134545,-0.08191795,-0.029509068,-0.021840857,-0.055838507,0.0069489684,-0.051005524,0.029057166,-0.0076586395,-0.013816655,-0.055645395,-0.03969391,-0.0011524275,-0.04345377,-0.014919268,0.0092331115,-0.05188584,-0.08842004,-0.01318774,-0.10569923,0.07461549,-0.014476224,-0.0008584994,0.0051712794,0.0057408134,-0.080791466,0.007722905,0.083835416,-4.7180973e-34,0.044777617,-0.032128777,0.024979006,-0.06336632,-0.0604041,0.03694335,-0.032670163,-0.038596336,0.03331644,0.07259916,0.0410156,-0.0531654,0.05740797,-0.044618107,0.0030216991,0.038531825,0.043545127,0.122855276,0.008686011,-0.027404862,-0.050553605,0.09701155,0.013013571,-0.029281205,0.04785085,0.042804465,0.0008808615,-0.0019190194,-0.00028545197,-0.009731053,0.013512639,-0.050278362,-0.013095742,0.01739879,-0.08206812,0.02845649,-0.052150432,-0.08466713,0.008614976,0.085568994,-0.035224117,0.018015517,0.07146394,0.04290321,0.049169257,-0.01334847,-0.012812327,0.014243737,-0.062750004,-0.008514416,0.033673245,0.03466966,-0.01845582,-0.003182861,0.026475683,0.07792203,0.051356837,-0.018431036,-0.029726349,-0.09198785,0.020449841,0.013120768,-0.034996316,-0.06581144,0.06723075,0.10021904,-0.0503324,0.060960297,2.9355702e-05,-0.022380186,0.028994061,0.11172256,-0.05312679,0.054538958,0.044686995,0.011674259,-0.034869786,-0.07219974,-0.0619983,-0.033072688,0.026090533,-0.045632962,0.07447391,-0.0057963533,-0.014586797,-0.08877608,0.0007327573,0.021319846,0.013189825,0.060637005,-0.0085765775,-0.008381514,-0.09152887,0.12167581,0.11843331,-3.2212874e-08,0.066369504,-0.06865156,-0.008507854,-0.07021665,-0.039879266,0.006240373,-0.005916789,-0.0033561348,0.056487918,-0.004739415,-0.1582073,0.09016904,0.021731881,0.03597931,0.007086493,0.0038863295,0.0104655055,0.026868194,-0.055288263,-0.026630742,-0.023702424,-0.0077350237,-0.03451883,0.0385827,-0.045500882,-0.054517865,0.032714095,0.060392134,-0.0064667463,-0.061878547,-8.028317e-06,0.05926937,-0.03328846,0.0077075595,-0.026216088,0.04276208,-0.03266704,-0.08332497,-0.04317749,0.033948146,0.0030563707,-0.090018705,-0.03902675,0.002051828,-0.06647893,-0.0020331442,-0.0011369747,-0.030623594,0.01578141,0.032289494,0.0035016227,-0.0025968389,0.015531095,0.005185503,-0.0020718726,-0.014956826,0.033528876,-0.006912748,0.0019733263,-0.040483758,-0.005396912,-0.007437908,0.18108454,-0.027573202 +6.3.2.40,Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in several fungi species. The enzyme is a non-ribosomal peptide synthase. It is also active with O-methyl-L-tyrosine forming 4'-methoxycyclopeptine.,384,1.0,-0.03853051,0.006020087,-0.13643916,-0.016658207,-0.026432712,0.062352102,-0.047292065,0.064507365,0.0813336,-0.023740008,-0.0076452647,-0.045469563,0.015538984,0.022729449,-0.11183247,0.08730282,-0.033061016,0.030558579,0.061624613,-0.053612392,-0.011575718,0.103413895,0.07119746,0.02772895,0.005385924,-0.005088383,-0.01797824,-0.01569543,-0.035408657,0.026820624,-0.005495112,0.029670939,0.0049136565,-0.033341758,0.071863964,0.017415734,-0.06529999,0.014400098,0.07118954,0.09177102,0.009641171,0.008967293,-0.0930313,0.012575213,-0.019275373,0.02020932,-0.016220365,0.04637125,-0.013669636,-0.017099475,-0.050369997,-0.045297895,-0.022561457,0.005306694,-0.039814282,0.032987352,-0.046128005,0.042697266,0.040576693,0.101491086,0.053980313,0.06657509,-0.038795993,-0.0016086326,0.030515673,-0.018473145,0.0027828272,-0.03629808,0.05560473,-0.088813886,-0.090754814,-0.08307444,-0.016295085,-0.014187323,-0.001883247,0.017019652,-0.0043701627,-0.01737401,-0.080605134,-0.094687544,0.03719175,-0.02002466,-0.011968057,0.009260762,0.050366376,0.017428197,0.018002262,0.088304676,0.06181651,0.014502963,0.059839413,0.012636955,-0.019346243,-0.0436924,-0.024905924,0.02988911,0.03517657,0.03483279,-0.0018828049,0.03599226,0.08234324,0.013963632,-0.018804586,-0.06623354,-0.058617305,-0.011049058,0.07196584,0.029195309,-0.019193057,-0.027767109,-0.007958435,-0.015618435,0.0079311365,-0.02318712,0.016869763,0.05929294,0.02830235,-0.017004212,-0.041092347,0.07811186,0.0065423665,-0.03364896,-0.036250986,0.031653754,-0.000551081,0.098749444,-0.14444387,3.5283418e-33,0.09171479,0.116388604,0.019212918,-0.019378476,0.021115975,0.038913663,-0.011094896,-0.042946193,-0.019801183,-0.07115831,-0.07091236,-0.06254633,-0.026718732,0.016610947,-0.0059582246,0.011854829,-0.04666357,0.027270025,0.018714897,-0.025155067,0.030389123,0.0072683496,-0.10758676,0.028087847,-0.010699627,0.106076196,-0.02899657,-0.016185042,0.008560896,-0.0030241087,-0.094761446,-0.061114613,-0.0987044,-0.029839884,0.045689903,-0.04884602,0.048924047,-0.093239605,0.033473004,0.016838696,-0.051441696,-0.007828448,0.03966309,-0.00736623,0.07440653,0.025363117,-0.116872564,0.049169138,-0.025593707,0.009232347,0.04678879,-0.05394358,0.099584185,0.017096289,-0.09902303,0.072670475,-0.041996308,-0.017813453,0.018998574,0.024860252,-0.03183105,0.07369071,-0.053754106,-0.002285918,-0.0056978357,-0.061546106,-0.04237835,-0.0732901,-0.027666561,0.058746174,-0.044642996,-0.019184504,0.053046893,0.097068034,0.06218565,-0.060718503,-0.09021088,-0.0014943868,0.0062223645,0.0035278762,0.045123525,-0.022949452,-0.002893859,-0.055231567,0.0057176137,-0.023778673,0.023934545,-0.09628892,-0.06835574,0.06242757,-0.016839813,-0.056116533,-0.0061628427,0.02646196,-0.0025491582,-3.7660683e-33,0.079775475,-0.04610387,0.033249043,-0.059495684,-0.045309633,0.04329905,-0.07616175,-0.06718724,0.00045645883,-0.06615637,0.028719522,-0.04609458,0.09388029,-0.0074252314,-0.04805953,-0.060313847,0.02453373,0.087860845,0.004201009,-0.018026011,-0.051338855,-0.031120429,0.005329355,0.026581628,0.06216745,-0.0007530017,0.015130175,0.08890292,0.01259934,0.09123264,-0.050305672,0.041797087,-0.00086596434,-0.07458855,-0.014031093,0.11321996,-0.061916944,-0.05260669,0.00663479,0.058772787,-0.05523673,-0.023673683,0.056049686,0.04441796,0.050273627,0.015674219,0.01530327,-0.011287526,0.001240188,-0.056241117,0.06817914,0.038077023,0.0045583993,0.012140172,0.055751335,0.020069834,0.018434525,-0.021219647,0.0048495075,-0.037210654,0.002179013,-0.00751128,-0.00097445963,0.018291974,0.07886824,0.03576165,0.020052327,0.105386674,0.100281216,-0.004614301,0.104539216,0.0143291345,0.05503561,0.072123006,-0.06798511,-0.004023929,-0.009728883,-0.047490902,0.016400892,-0.06424844,0.02368289,-0.010442544,0.0672127,-0.016804527,-0.07933909,-0.09640349,0.05635892,0.09947448,-0.027591359,0.021229945,-0.0032248255,0.01866211,-0.005448007,0.077289425,0.04980479,-3.5928426e-08,0.09379491,-0.008817134,0.030258214,-0.061445437,-0.026468018,-0.021886213,0.04163024,-0.05868851,-0.011584722,-0.054824077,-0.04093651,-0.011521112,0.01573652,0.076009795,0.048590366,0.009774808,-0.0023890948,0.079439186,-0.017264927,0.05581609,-0.027876368,0.050049044,-0.06763538,-0.030980656,0.0018075696,-0.10052466,0.027444419,0.03871243,0.10275042,0.012469202,0.0048402934,0.0043401327,-0.0018481185,-0.0373759,-0.06583966,0.015178443,-0.09215823,-0.05198507,0.026431043,-0.06849086,-0.0029818679,-0.043228578,-0.06452909,0.004695659,-0.042285204,-0.08325252,0.049123995,-0.028805986,0.0053808987,-0.018475018,0.020524485,0.03512061,0.05076707,-0.09605485,-0.03773066,0.026405921,0.0013316264,-0.0054652276,-0.0061641075,-0.16770454,-0.07876906,0.015474097,0.1602461,0.0070594023 +6.3.4.21,"The enzyme, which is involved in pyridine nucleotide recycling, can form beta-nicotinate D-ribonucleotide and diphosphate from nicotinate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) in the absence of ATP. However, when ATP is available the enzyme is phosphorylated resulting in a much lower Km for nicotinate. The phospho-enzyme is hydrolysed during the transferase reaction, regenerating the low affinity form. The presence of ATP shifts the products/substrates equilibrium from 0.67 to 1100 [4].",384,1.0,-0.00627138,-0.015154606,-0.006624618,-0.057979688,-0.020569906,0.034174558,0.03311296,0.013165481,0.05069817,0.04737228,0.013133614,0.054076694,-0.08656458,0.039654482,-0.013869851,-0.03366412,-0.04278075,0.091518894,0.037429273,-0.0034764379,0.099814415,0.0070299823,-0.040988814,-0.01758284,0.027676858,0.03201959,0.0067014876,-0.026615191,-0.024508102,-0.008461949,-0.12158637,-0.053101223,-0.02152518,-0.036459696,0.0405248,0.10996241,-0.09814476,0.0075144772,-0.051941734,0.020094398,0.071661055,0.016820798,-0.048060052,0.058208458,-0.0814237,0.04624654,0.05688408,0.1126086,0.016070053,-0.085237585,-0.058601618,-0.020292968,-0.044105332,-0.06424074,-0.028406015,0.101872444,0.0044536265,-0.012182371,-0.016627517,-0.020550586,-0.029150745,-0.0021443504,-0.0055062324,-0.004197787,0.12737142,-0.08818633,0.047821417,-0.036251266,0.022259673,-0.09590241,-0.060221005,0.018919403,0.00535299,-0.02685834,0.05150966,0.017697975,-0.08363327,-0.004259646,0.019568402,0.02731728,0.062985614,-0.05581064,-0.035535816,-0.007278571,-0.007913911,0.009898506,-0.0065129474,0.03416682,0.05235056,-0.014431111,-0.00855424,0.06081081,-0.05073145,-0.0066050454,-0.12897596,0.040329583,0.012577116,0.074759305,-0.045259397,-0.033834197,0.058493514,0.10266844,-0.02490824,-0.045456737,-0.03547932,0.059735857,0.021194167,0.0098838825,-0.022025855,0.048345,0.0023903132,0.076494984,0.003987825,0.03391454,-0.0008148342,0.10754604,-0.039414536,-0.069547676,-0.08471488,0.018173955,-0.06795097,-0.020832436,0.018201869,0.072291486,-0.06951536,0.058835447,-0.034224875,2.9494468e-33,-0.025283292,0.050341014,0.04190482,-0.0134161385,-0.023528801,-0.031135617,-0.09482383,-0.040684223,-0.05594597,-0.07169687,-0.031542797,-0.1035325,0.032987684,0.024155485,-0.048911978,-0.06220566,-0.040545102,0.09867084,0.09931037,-0.020628419,0.013883273,0.03688823,-0.042284098,0.0663997,0.019236907,0.09274453,-0.11212823,0.029366592,0.037553456,-0.018182354,0.07546006,-0.025319148,-0.1054602,-0.09834752,0.03529194,-0.044362016,-0.047061715,-0.00080278766,0.0022865403,0.011031134,-0.012935268,-0.022350837,0.036697105,-0.006103975,0.012634947,-0.12645032,-0.039029613,0.033789743,0.0052784854,0.041130148,0.030057603,-0.082054906,0.10539864,-0.03565913,-0.077000074,-0.018873123,0.0338535,-0.04683434,-0.011992479,0.05279944,0.036242206,0.052617487,-0.028788036,0.0012528688,0.005327029,0.0072656134,-0.04357729,-0.092817366,0.033840515,0.09092206,-0.0048877345,-0.015261959,0.037705183,-0.03201729,-0.004586331,-0.027304448,-0.016409302,0.027516523,-0.058433596,0.03770631,-0.0060831574,-0.02373652,-0.01379112,-0.0053553954,-0.018844437,-0.061258536,0.06184997,-0.08452436,0.018470788,0.07250436,0.05187889,-0.032694943,-0.070408955,0.014328782,0.10102641,-3.6827672e-33,0.07973076,-0.042882334,0.048538137,-0.05488509,-0.03706606,0.0010634862,0.05569161,0.029883336,0.008207111,-0.07218921,-0.059881058,-0.042307965,-0.012098403,-0.03548201,-0.058202803,0.008257573,0.014882184,0.072624944,0.032313187,0.037152037,0.0064545213,0.09068867,0.04535669,0.067871995,0.0637628,-0.05420215,0.015320842,0.051690515,0.026126487,-0.0120810345,0.014265057,0.032697123,-0.0076648123,0.013670513,-0.0038071235,0.035508715,-0.054566294,0.053833712,0.062315963,0.09362736,0.02631894,0.065228336,-0.0148687605,-0.017663328,0.04092568,0.0453432,0.0107163675,-0.010785931,-0.017913722,-0.023920177,0.06897885,0.027448846,0.00493409,0.049786363,0.104271315,0.052742817,-0.021540392,0.08956011,0.01437379,-0.05495977,-0.05083284,-0.10571547,-0.07468855,-0.039970804,0.0996044,0.02508155,0.0003757447,0.043330528,0.0068707285,-0.030208953,0.019170668,0.07403713,0.03365353,0.014286814,-0.019458711,-0.01798118,-0.046452418,0.040204503,0.0057254313,-0.042064704,-0.06752277,0.07824823,-0.063388325,-0.107281625,0.039703213,-0.05409321,0.020546818,0.047839914,-0.033255376,0.009850473,-0.009323469,-0.07206873,0.039699454,0.0024292464,0.034355726,-4.171021e-08,0.046484273,0.0051068184,0.033544984,-0.0050818315,0.030077077,0.028524488,0.040343408,0.0042628017,0.0290302,0.0010082584,-0.007942291,0.030714862,0.04327567,0.04164587,0.0899571,0.048048854,-0.11971102,0.017599316,-0.037327956,0.0068023056,-0.04438495,0.028436365,-0.12991433,0.08385718,-0.00034500024,0.012942501,0.08956823,-0.009667886,0.00019442561,-0.057058204,0.083183356,-0.02427496,0.04771157,-0.06669465,-0.0575707,0.0058866115,-0.053844683,0.059881825,-0.034981187,-0.008926652,-0.046762824,-0.06805345,-0.015655259,0.0020683294,-0.028577529,0.017855361,-0.02100339,0.04667818,0.009360032,-0.026954144,0.040765703,0.03704274,-0.03151329,-0.14858243,-0.11770986,-0.029285211,0.006484946,0.006178288,-0.035949834,-0.07836952,0.071061954,-0.016609801,0.074077405,-0.03637074 +6.3.4.22,"The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNAIle2 at the oxo group in position 2 of cytidine34. This modification is crucial for accurate decoding of the genetic code. In bacteria EC 6.3.4.19, tRNAIle-lysidine synthase, catalyses the modification of [tRNAIle2]-cytidine34 to [tRNAIle2]-lysidine34 . ",384,0.99999994,-0.090536006,-0.023879424,-0.07770595,-0.050728448,0.047292188,-0.09687692,-0.07339706,0.021566518,0.022495538,0.033120442,0.060033735,-0.072743095,0.002368698,-0.013676647,-0.10900458,0.014863535,-0.12786786,0.04473455,0.050676387,-0.018969024,0.032866407,0.0840866,-0.02403293,0.0329909,-0.04122506,0.03873046,-0.07144436,-0.0121193575,-0.031047627,-0.080692805,0.02940587,0.012409474,0.14463918,-0.05190452,0.075036325,0.017320944,-0.036592048,-0.043472376,0.13358302,0.023206094,-0.03746932,0.04944937,0.059007958,-0.035790272,-0.05515255,0.019955462,0.04734827,0.026664013,-0.0039662183,0.08151966,-0.03864318,-0.0012439903,-0.060500834,0.028725654,-0.0028833733,0.120180026,-0.0097414665,-0.011849283,0.014990327,0.0018424361,0.09044313,0.089295425,0.035415515,0.009151007,0.0010953732,-0.08394728,-0.01608738,-0.023629075,0.08352186,-0.04654772,-0.01679704,0.0034818146,0.025448913,0.03452315,0.0026096764,0.09541962,0.005615554,-0.040584195,-0.0051083085,-0.010633922,-0.035267584,-0.060288105,0.044997044,0.015194492,0.059896488,-0.05923556,0.04412538,-0.009462739,0.038014587,0.03545078,0.09877628,-0.010629181,0.046014056,-0.032628898,0.0060731354,0.045067996,0.02801317,0.040505767,-0.03299132,-0.0059011187,-0.035702895,-0.010473529,0.014031635,-0.06519058,0.036846012,-0.07981869,-0.017712973,0.059855055,0.009344404,-0.023081582,0.04148037,0.010542458,0.054371476,0.023362858,-0.014054541,0.050763823,0.028207477,-0.060202774,-0.06363518,-0.037663423,0.011328573,-0.02174095,-0.01467506,0.0003855596,-0.010996452,0.0019534826,-0.11172339,3.8061005e-33,0.01487934,0.037509035,-0.01332644,-0.057700615,0.01750916,-0.040502697,-0.07409822,0.03037335,-0.027983403,-0.034014247,-0.09387511,-0.04365188,0.05769113,0.020952798,-0.024828834,-0.01384817,-0.071804315,-0.0025943154,0.015597478,0.024419272,0.025002023,0.042788967,-0.00466837,-0.037441913,0.049343627,0.11560654,-0.036874108,-0.07828908,0.04488025,0.04153948,-0.012440331,-0.10727504,-0.05883414,-0.021294355,0.079293795,-0.016929314,-0.026977822,-0.071337536,-0.09887686,0.0025126026,0.004264357,0.037355714,-0.0024541167,-0.051972363,0.04073565,0.010230507,-0.0214216,0.063813016,-0.0030038569,0.07297453,0.017184181,-0.019086545,0.005881681,0.040659502,-0.057713713,-0.039446313,0.005449631,-0.0262582,0.05432245,0.029448196,0.017786788,0.058516115,0.028395949,0.00034165516,-0.041952383,-0.035945337,0.0034443503,-0.031847548,0.01894834,0.065413006,-0.020514362,-0.05869804,0.030557426,0.035150293,0.007830599,-0.03186438,-0.047054976,-0.055687465,-0.008940124,-0.016050708,0.013945138,-0.020655543,0.009995639,-0.02020996,-0.025269588,-0.03463804,0.019271536,0.035031777,-0.019265098,0.11196224,-0.009282075,-0.104541354,-0.043891646,0.049943447,-0.009598183,-4.6543063e-33,0.05223174,-0.10959596,0.015514225,-0.08346034,-0.14626224,0.054773886,-0.07004615,-0.0487709,-0.0071676793,-0.069385685,0.08385316,-0.0035622152,-0.035409812,-0.021141436,0.041568425,-0.08219835,0.04007629,0.022311887,-0.021619113,0.00043846504,0.07894946,-0.018285483,-0.010570997,0.03171529,0.089431204,0.011412211,0.086034745,0.014840586,0.010079917,0.052116368,-0.108928435,0.034781195,0.009869837,0.0013849415,-0.035346046,0.036971893,-0.043925125,-0.017269159,0.05288742,-0.0027124914,0.03782162,0.025197776,0.01370464,0.075472586,-0.0050085033,0.030103799,-0.016743729,0.048296995,-0.0005687899,0.037555255,0.088077284,-0.008510691,0.036057983,-0.047624066,0.05919675,0.0077418014,-0.069989994,0.038847107,-0.09039588,-0.0060965642,-0.06494764,-0.092730604,-0.046511687,-0.041285772,0.06494507,0.051932015,-0.052512936,0.1282099,-0.024645,-0.035880815,0.053718507,-0.038409453,0.04857584,0.041993104,0.029401254,-0.05375938,-0.03705355,-0.027817125,0.055934686,-0.067825675,-0.08560817,-0.024238704,0.086126626,-0.031037917,0.005337715,-0.04623654,-0.015706113,0.09061868,-0.013621372,0.019631606,0.0006434447,-0.012196226,0.015681423,-0.05981284,0.075554885,-4.0611404e-08,-0.006502371,-0.053774577,0.02620176,0.012044346,0.019773733,0.09070811,-0.019226668,0.060377434,0.02017272,0.013267385,0.11441331,0.09973871,0.0001965064,0.0028532606,0.005231478,0.1476487,-0.13637674,-0.020655744,-0.03089731,-0.0059359097,-0.06266771,0.026732426,-0.12153866,0.015872408,-0.0067187585,-0.030205032,0.014016179,-0.030984154,-0.04919872,-0.038272057,0.044634532,-0.029784316,-0.047285493,-0.014103406,-0.03180238,-0.008057601,-0.001378736,-0.070485644,-0.041170716,0.029917276,-0.01968854,0.06143149,-0.12581016,-0.017553924,-0.014311712,0.04672868,0.024826836,0.06925652,-0.035135265,-0.0023011924,0.010592883,0.029159987,0.051518127,-0.02040827,-0.09078427,0.029461231,0.02721473,-0.06126373,-0.031597786,0.061715804,0.024762124,-0.01718976,0.16714732,-0.003445699 +1.1.1.354,"The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.",384,1.0,-0.052262317,0.007091498,-0.05007627,-0.06092403,0.070366226,0.07949103,-0.11952471,0.06326582,0.0059101772,-0.033449717,0.08868357,-0.00866996,-0.09865251,0.059887096,-0.021314994,0.0052269017,-0.032463297,0.01731214,0.040393475,-0.03168299,0.014100485,0.017990282,-0.012160979,-0.027828569,0.08899204,-0.014099256,-0.013756092,-0.03497184,-0.0032137472,-0.025297336,0.010413327,0.018432563,-0.020718075,-0.037115358,-0.04859394,0.05643427,-0.015022479,-0.107268296,-0.004018145,0.10922682,-0.005605619,0.020407917,-0.0901449,0.030643143,-0.06950383,-0.033067595,0.008882592,0.036862105,-0.015774777,-0.004320283,-0.1241562,0.008972248,0.046450082,-0.06237165,0.032283396,0.022123622,0.0018975163,-0.031808246,-0.044525,-0.008142441,-0.008811186,-0.06918852,-0.017560882,-0.0073295883,0.0244996,0.010213418,0.06587129,-0.036481783,0.018776251,-0.024341788,-0.057089064,-0.025316909,-0.012084277,0.052532688,-0.055217903,0.03874367,-0.08658307,-0.017266486,0.08035048,-0.061866254,-0.0405401,0.035351664,-0.0073605287,0.07211539,0.0821772,0.0062736166,0.0070940997,-0.01843195,0.027935963,0.017654354,0.044049643,-0.05623308,-0.026536869,0.013274033,-0.07765791,0.079911485,0.046216078,-0.026430769,-0.07809342,-0.052325733,0.016419644,0.07760821,-0.04576559,-0.044492077,-0.0726526,0.0385939,-0.009504854,0.035400614,-0.07839686,-0.019511944,0.019750535,0.014261799,0.059808563,-0.017728353,-0.07606762,0.035535626,0.049805697,-0.06560401,-0.027752638,-0.030541718,0.020759888,-0.019198446,0.0024093199,0.046926852,0.027471187,0.031508423,-0.043788437,3.6051894e-33,0.055378787,-0.021142485,-0.03044181,-0.06880983,0.018137716,0.0026076648,-0.119302094,0.051240556,-0.045760002,-0.04219802,0.0009707961,-0.00097467063,0.019086769,-0.038869973,-0.0036226313,0.052548714,0.032051887,-0.042791855,0.01868059,-0.019471398,-0.0025836863,0.08788179,-0.0072123706,-0.037936017,0.018144693,0.07752258,-0.008064088,-0.01326543,-0.042022273,0.010468141,0.067089684,-0.1770252,-0.11119737,0.0866864,-0.015317027,0.05838059,-0.086305976,-0.06570231,-0.067453444,0.02706094,-0.060203873,0.09695437,-0.00022984987,-0.016417796,0.027671518,-0.10458311,0.0118770795,0.1039196,4.700854e-05,0.043252476,0.059813462,0.0023554864,0.042123932,0.012829322,-0.072731875,0.05897569,0.0074514267,0.04232729,0.021311391,0.08064194,0.017502287,0.021994904,0.0048839645,0.02759723,0.026592042,0.017169928,-0.10412444,-0.04901365,0.04992616,0.07971512,0.0008414979,0.00049838517,0.06056858,0.06992631,-0.051285584,-0.018690418,0.050362684,-0.025885167,-0.030707475,0.011296417,-0.056238845,-0.039104708,0.01800408,0.02667445,-0.037831686,0.07212132,-0.04692609,-0.0028763965,-0.0014043939,0.06323,0.09843459,-0.03916362,0.03367186,-0.0023132176,0.019162165,-3.1311948e-33,0.014069278,-0.055895142,0.023653138,-0.13703863,-0.068929024,0.1414886,0.018106015,-0.046366543,-0.031724755,-0.0345822,0.0068294853,0.04691424,0.030446649,-0.026342973,0.012207138,0.052566845,0.045840714,0.045728903,-0.04344357,-0.042448677,-0.023111949,0.17718716,0.06478563,0.043645382,0.028873784,0.003992258,0.015381055,0.027651554,-0.03025002,-0.0138254175,0.032909114,-0.004993086,-0.08111088,-0.04589259,0.046588976,-0.009288045,-0.073122956,0.031570986,0.039601576,0.01660031,-0.023047969,-0.0064151688,0.013123161,0.0626082,0.095385425,0.054478757,-0.11882811,-0.10616436,0.00458347,0.0004950533,0.013309581,0.10083559,-0.030605149,-0.01116295,0.057421926,-0.030186424,0.02681662,-0.061264053,0.06745663,-0.027107038,-0.01871812,-0.002188192,0.002295266,0.02806789,0.07354063,0.007375589,-0.032448445,0.07068119,0.0339037,-0.03361139,0.07692237,0.06976594,0.022633534,0.07905674,-0.08237148,0.017188596,-0.025715504,0.014990144,-0.006382625,-0.03963373,0.0052500293,-0.023894273,-0.01648521,-0.07992645,-0.019838773,-0.020283729,0.0038903484,0.079692386,0.044532962,0.01792057,0.025648545,0.004117299,-0.064289026,0.07152668,0.06632529,-3.645415e-08,0.023958929,-0.050339714,-0.0047437316,0.0011566245,-0.027554277,0.0022102683,-0.010078926,0.026670042,-0.001597994,-0.020484624,0.017913045,0.0889084,0.010307146,0.06999534,0.053718556,-0.0025427113,0.012865994,-0.027234545,-0.037209127,-0.0274308,-0.053696968,0.0059433803,-0.08971426,0.082991935,-0.025617037,-0.08384379,0.018776245,0.027471064,0.060034294,-0.079654776,-0.015818011,0.04747252,0.021086173,0.047815915,-0.03222142,0.054713774,0.034174696,0.0057147327,-0.04332435,0.056969453,-0.0660204,-0.08615067,-0.007118332,0.017210517,-0.019654676,0.019654442,0.103029065,-0.097912654,0.047784932,-0.006977611,0.07686911,-0.02331741,0.10596628,-0.018995719,-0.11233592,0.02537624,-0.011458598,-0.07841694,-0.00017411516,-0.07310661,0.06587012,-0.006687539,0.11432555,0.042439297 +1.1.1.355,Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin 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+1.1.1.356,"The enzyme is involved in biosynthesis of L-colitose, a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyses the reaction in the reverse direction. The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar. The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H [1]. 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The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. This entry stands for enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known. [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) and EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)].",384,1.0,-0.03075737,-0.04867627,-0.055815462,-0.10406801,0.0065552155,0.018791148,-0.10559184,-0.0018173264,3.782483e-05,-0.018061647,-0.0028334004,0.012313581,-0.10407913,0.020750279,0.032343768,0.046103816,-0.079896264,0.03389239,0.069593675,-0.05269583,0.07450661,-0.018013792,-0.046934787,-0.027486166,0.058671832,0.018943297,0.042493973,0.062469337,-0.09060679,-0.047184568,-0.010949169,-0.00901979,0.034476724,-0.023122089,0.0077027692,0.092173114,-0.123178646,-0.08051857,0.07341092,0.11317097,0.030249448,-0.042953826,-0.07474975,0.0062436415,-0.021592857,-0.04389598,-0.06766817,0.06329388,-0.011387521,0.011916263,0.025527146,-0.05452196,0.041887257,0.05200734,-0.017754657,-0.039241068,0.016472936,0.0114726,-0.061748028,0.034568503,0.014041921,-0.022165967,-0.007933007,0.038018093,0.057040192,-0.005440896,0.024712076,-0.10129792,-0.037050635,-0.024138857,-0.07535816,-0.042713955,0.0050332397,0.04300887,-0.07180186,0.0035544834,-0.016919252,-0.038114697,0.022928134,-0.062147487,0.043780006,0.00763871,-0.031087616,0.058745183,0.07493276,-0.031139327,-0.054081235,-0.019010665,-0.025634892,0.08425864,-0.012410155,-0.0064701713,0.0062304186,0.022166174,-0.02447601,0.06792044,-0.028865697,0.006863839,-0.0051447838,-0.07019463,-0.01856475,0.051359244,-0.0498055,0.012458039,-0.022116283,0.05028728,-0.01114567,0.071875565,-0.07184479,0.01919338,-0.012512901,-0.0533311,0.06697978,-0.00064123847,-0.0014518201,0.15058683,0.059228566,-0.022766147,-0.055817507,-0.0712308,-0.012094957,-0.015383496,0.05460358,0.0020538406,-0.0030479927,0.082130164,-0.06739351,1.4271936e-33,0.086148694,-0.01077381,-0.07760647,-0.0058375695,-0.012726731,0.0622118,-0.017605525,0.06711936,-0.043361757,-0.026610294,-0.012605267,-0.015110746,0.07498487,0.013761657,-0.002184812,0.018810641,0.07382241,0.054645196,0.02022698,-0.01217382,0.0031527742,0.065214306,-0.051434334,-0.01391752,-0.010253136,0.036530152,-0.04691547,0.029999005,-0.021935735,-0.019361202,0.009821208,-0.120567136,-0.045307465,0.008183505,0.05217512,-0.03320632,-0.021908974,-0.027358294,-0.027197361,0.06420386,-0.028195273,0.012529729,0.023030488,-0.05935153,0.039515704,-0.011638266,-0.061974358,0.054478277,0.056712292,0.02072918,0.06016864,0.014057637,0.06307265,-0.0713324,-0.031625886,0.065573156,-0.026639452,0.008408027,-0.023946878,0.05644848,-0.009037217,0.061616514,-0.024746872,0.060596254,-0.03619811,0.020746762,-0.040609278,-0.08631562,-0.026817642,0.10307785,-0.043182764,-0.012551894,0.052165695,0.006114915,0.0016372312,0.029272616,-0.030494938,0.045310207,0.028631156,-0.061654277,-0.052395962,0.0047994815,0.010815876,-0.0005407039,-0.04649245,0.084590845,0.03572238,-0.05085859,0.053894963,0.03294412,0.093936145,-0.036902767,-0.09070524,-0.018783335,0.04502903,-3.0396526e-33,0.0545385,-0.062867954,0.020986792,-0.16623183,-0.042795654,0.16828385,0.0050448705,-0.02391294,-0.0009571436,-0.003464352,0.012381552,-0.0029696533,-0.08468658,-0.11744143,0.055368833,-0.05235112,-0.05575597,0.02060093,-0.08786032,-0.011524434,0.093368776,0.1226902,0.016376,0.06461361,-0.013726644,-0.034377046,0.010260999,0.051582552,0.058598258,0.04995914,-0.024290089,-0.00412309,-0.02861798,0.020555079,0.0969061,0.07304544,-0.052243847,0.018582486,-0.0036102915,-0.00637895,-0.028332146,0.034599904,-0.047592252,0.048566762,0.05148538,0.07163495,-0.08934723,0.030447988,0.023229768,-0.033221953,-0.0074715177,-0.0581493,0.006419606,0.0061346013,0.00013532105,-0.007908896,-0.0030568023,-0.043152012,0.014392753,-0.023053786,0.035122264,-0.057914305,0.031600397,0.039439686,-0.032871276,0.018601445,0.006988382,-0.027990356,0.032011095,0.02905033,0.034875207,-0.0029547452,-0.04026028,0.0483351,-0.066063575,-0.051270213,-0.10475191,-0.01729333,-0.016395861,0.04110084,-0.015226838,0.04187805,-0.013727298,0.036366355,-0.020434646,-0.03129805,0.019390885,0.1301663,0.03130388,0.027445322,0.00871542,0.013634042,-0.14313303,0.018843362,-0.023863662,-4.244417e-08,0.06604066,-0.012883407,0.060941987,-0.032618575,-0.0232451,-0.00611546,0.050400898,0.0061822576,0.124417074,-0.007387166,-0.0075890385,0.12694333,0.049261656,0.031316858,0.07119176,-0.044289887,-0.0075092833,-0.0035856531,-0.011023677,-0.0038325607,-0.074617006,-0.017146364,-0.06148546,0.030789025,0.039825104,-0.011749738,0.003180804,0.057024173,0.0398177,0.020251933,0.04504467,0.0032103225,0.055598192,-0.0030942638,-0.020528708,0.037307292,-0.006336986,-0.04249462,-0.033970132,0.042664185,-0.053605214,-0.09946845,-0.038247842,0.04809042,0.03388633,-0.0038661913,0.0058231195,-0.01803244,-0.011987896,-0.01311534,-0.054562148,-0.049334567,-0.020960672,-0.022792332,-0.09926904,-0.02088854,-0.07417327,-0.10714571,-0.042448837,-0.055539645,0.08916746,0.013156836,0.21571702,-0.021085232 +1.1.1.358,"The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B5). This entry covers enzymes whose stereo specificity for NADP+ is not known. cf. EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific) and EC 1.1.1.214, 2-dehydropantolactone reductase (Si-specific).",384,1.0,-0.088605575,-0.022014981,-0.060904894,-0.106878206,0.07100501,0.0766108,-0.031793423,0.049855478,4.400772e-05,-0.005050498,-0.052794684,-0.00233531,-0.07977073,0.0035440468,-0.0388976,0.03541237,-0.04805012,0.016735893,-0.031484675,-0.059772983,0.03756722,-0.007379396,-0.009397202,0.009027515,0.09777923,0.005500268,0.061273407,-0.007826866,-0.09844291,-0.06608335,-0.06173239,0.054836035,-0.0035073378,-0.062328737,-0.0052158628,0.0689678,-0.0842417,-0.000570367,-0.018648298,-0.051089954,0.056177318,0.0018846564,-0.042221185,0.0454321,-0.0016557531,-0.007439453,-0.052572552,0.06779846,-0.018890783,0.034702424,-0.08405152,0.01745682,-0.01281944,-0.00081364374,0.04954759,0.009297986,0.0059502963,-0.033576,0.008706384,-0.028172899,0.05608656,-0.12784705,-0.024588436,0.005740089,0.043631308,-0.02177692,0.08732128,-0.025388893,-0.030727858,-0.030905949,-0.075225964,-0.04981931,0.0074122115,0.041795593,0.008040974,0.051541973,-0.044390157,0.030209458,0.008750516,-0.0149440905,0.03579281,0.103730775,-0.039686933,0.093690686,0.06721937,0.012787282,-0.031223958,0.023811905,0.005137468,0.00800851,-0.002189433,-0.036730558,-0.020074971,0.021957874,-0.13100201,0.035795294,-0.015932648,-0.039222233,0.015913174,-0.060649153,0.027931882,0.0657492,-0.0061604707,-0.020247495,-0.08799068,-0.051823217,-0.012071172,0.09015352,-0.037019957,-0.0099961385,0.054642297,-0.00035383558,0.03071511,-0.032553874,-0.0020344835,0.09181783,-0.0064626313,-0.032528497,-0.08414167,-0.015522061,-0.012957566,0.006435738,0.049945034,0.0008441035,-0.07050291,-0.053742487,-0.13870572,1.8005159e-33,0.08604858,0.03947055,0.01457219,0.03102807,0.06275196,0.0013422532,-0.07237712,0.056985933,-0.054608684,-0.036154903,-0.09366067,-0.08265746,0.059070926,-0.017187212,-0.07759295,0.047822572,0.017951101,-0.06667391,-0.00922229,-0.013607415,-0.0020329861,0.12834898,-0.08297743,0.031119121,0.025028598,0.048487037,-0.0134373335,0.031117149,0.027330073,-0.0070596817,0.05061509,-0.070890464,-0.06279707,0.03409156,0.10358459,-0.013085905,-0.020787952,-0.036999196,-0.018935034,0.12414448,-0.005846644,0.051882837,-0.037030928,0.040592283,0.08119532,-0.070907585,-0.010710992,0.064206176,0.012048928,0.062127694,-3.5067904e-05,0.022583531,0.12753111,-0.026579544,-0.041207936,0.06353097,-0.049687475,0.03276563,0.008451893,0.07733114,0.061984226,0.053042784,-0.028918587,0.0077679227,-0.055328537,0.05041951,-0.08696659,-0.083159946,0.009277356,0.047070943,0.025405504,0.0044447794,0.07362311,0.04288912,0.05151397,-0.058743987,-0.009636158,0.0162715,0.022900762,0.005214886,-0.02071813,-0.010101157,-0.017678687,-0.0049902555,-0.09468759,0.0176026,0.020071868,-0.065536946,0.028573556,-0.012965967,0.095551655,-0.0625754,-0.03759274,-0.051017825,0.02304679,-2.5023275e-33,0.029135501,-0.087684944,0.04101772,-0.055606067,-0.007674981,0.08699134,0.06928038,-0.12203305,0.0015741691,0.0042160107,0.054751378,0.035023473,-0.019349547,0.013398279,0.008502719,0.005268426,-0.011768002,0.09095013,-0.039373286,0.026562853,-0.011046444,0.088040546,0.052459665,0.007992777,0.022116015,0.024491109,0.0038380222,0.08977917,0.046116143,0.007764472,-0.0153608555,0.0373533,-0.13383234,-0.037131187,-0.009993935,0.050248343,-0.07934111,0.0043449346,-0.080868065,0.05050818,-0.08725164,0.016642448,-0.001415538,0.04277052,0.05637922,-0.024258915,-0.094795085,0.09687557,0.03745262,-0.0754869,0.052084025,0.06616216,-0.020828772,0.033039566,0.05649676,0.0040622414,0.03760135,0.011489057,0.036989365,-0.0017212944,-0.0021503672,-0.109608196,0.06925468,0.048014518,0.07304851,0.060942695,0.029022612,0.07726545,0.022276442,0.008358221,-0.0017403441,-0.025372854,0.042185437,0.0075548235,-0.061935164,-0.040920872,-0.09587977,0.015572256,-0.016731136,0.0052141943,-0.01975312,-0.051618617,-0.0015656371,-0.03168104,-0.045273148,-0.05658531,0.025705127,0.0695323,0.0012622883,0.031553604,-0.045876887,0.01595,-0.101608746,0.070189945,0.030739352,-3.738759e-08,0.10219897,-0.042315986,0.0043034977,-0.034067817,0.03719556,0.005957528,-0.023585023,-0.026764728,0.08584326,0.027952243,-0.06139369,0.09733863,0.035091344,0.037583563,0.030144587,0.053143393,0.022805547,0.021162992,-0.020275092,0.00735517,-0.038929384,0.024095098,-0.10988819,-0.008057279,0.03936026,-0.06747285,-0.01431558,0.021183696,0.09246693,-0.082214095,0.0049550626,0.010322668,0.06270382,-0.027866608,-0.060595095,0.055553388,-0.050097633,0.034053262,-0.032364767,0.036697056,-0.057311546,-0.105884954,-0.03750027,0.05074874,-0.019038495,-0.0062813303,0.0405733,-0.018440614,-0.06413104,-0.0057653966,-0.039574455,0.021766802,0.02700801,-0.035244424,-0.08423304,0.04329088,0.012262587,-0.06118424,0.00472045,-0.029706502,-0.04769106,-0.0039616693,0.08984421,-0.03974768 +1.1.1.359,"The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway. ",384,1.0,-0.039922174,-0.051956914,-0.04322121,-0.017675042,-0.015910873,0.006417706,-0.1049451,0.0014874985,0.050289307,0.019884078,-0.0061032213,0.010149246,-0.05785519,0.035833385,-0.0676946,0.04134274,-0.07085353,0.05378047,0.026440242,0.031152604,0.12790976,-0.0042035365,-0.01562174,0.01354204,0.0812338,0.001407188,0.009453552,-0.022415046,-0.08468764,-0.03190864,-0.02763084,-0.042096566,0.038266145,-0.04301896,-0.013365283,0.10462911,-0.017710628,0.0060924734,-0.010320172,-0.013935939,0.00060292264,-0.048008025,-0.014925956,-0.01169827,-0.03342928,-0.04342236,-0.00895327,0.062099855,0.06559103,0.018955413,-0.06907403,-0.096294165,-0.05216019,-0.038687326,0.0977984,0.009867618,-0.0035956015,-0.0048413672,0.012008496,-0.022491064,0.07026899,0.027489431,-0.058520835,-0.0048116427,-0.011106415,-0.026653118,0.037502967,-0.02691942,-0.021029001,-0.06261704,-0.03395726,-0.042527236,-0.04856784,-0.025663015,-0.0009909325,0.079745546,-0.0353823,-0.06382383,0.003357815,-0.02024228,0.09866872,0.05774159,0.011892492,0.04225378,0.06818222,-0.006912017,0.036128804,0.0406407,0.0089356555,-0.06825999,-0.004255163,-0.06929466,-0.07337537,-0.024565842,-0.0534416,-0.039446186,0.018784365,0.076974116,-0.032162987,-0.025291648,0.036070187,0.029750617,-0.0019562673,-0.09744615,-0.04037109,0.01647864,-0.0024191397,0.14525819,-0.00739426,0.00085601053,-0.00834699,0.010921098,0.021295546,0.027038654,-0.03368591,0.13988082,-0.01558751,-0.06757178,-0.11962115,0.0245839,-0.036045995,-0.0013240179,0.08502699,0.058332473,-0.020560382,0.01979375,-0.060764372,1.0392918e-33,0.11255486,0.012314141,0.01080933,0.0123618925,0.021736657,-0.057175025,-0.05991461,0.06735992,-0.07556274,0.013049613,-0.07038515,-0.009013262,0.029100198,0.09221985,-0.043907724,0.013616452,0.020325504,-0.038082805,0.018179048,-0.012806873,-0.026489366,0.077166766,-0.013384319,-0.010935241,0.06595928,0.0003346495,-0.008463688,0.05118019,0.0110813845,0.003895263,0.021305146,-0.14362505,-0.112292826,-0.0030226088,0.01941422,0.030519886,-0.039069995,-0.0022844083,-0.050534047,0.013871558,0.010549661,0.009405291,0.00053594395,-0.10590575,0.027221328,0.013522649,0.03927455,0.037466634,0.030621665,0.08946233,0.06292027,-0.019965313,0.034492474,0.032252997,-0.07915965,0.003416096,-0.017721532,-0.002705452,-0.011821505,0.07459729,0.030712064,-0.0031815667,0.012188276,0.016445244,-0.036004905,0.020570932,-0.08255605,0.0013916502,0.02918495,0.07278448,-0.053839073,-0.006708335,-0.00078772707,0.01668493,-0.017557036,-0.030813228,0.033832047,0.029310843,-0.016190488,-0.015339797,0.01898902,-0.0025125283,-0.0031183662,0.042747986,-0.06102118,0.052925173,0.019529866,0.011926748,-0.07061254,0.037488323,-0.055386767,0.0013782707,-0.09673975,0.026760595,0.10246517,-3.0470564e-33,0.10911554,-0.10464613,0.097086124,-0.14173546,-0.074726604,0.116753474,0.049382906,-0.05701113,0.019568346,-0.06362415,0.0676657,0.046856448,0.061488666,-0.091134086,-0.007610875,-0.040715046,-0.05953102,-0.018689558,-0.021932144,-0.033532355,-0.01895617,0.14333305,-0.009968084,-0.09056763,0.0412064,-0.02358566,0.0017674023,0.06462781,0.0011969088,0.04953598,0.015833544,-0.0074877045,-0.029716915,-0.037673574,-0.03752513,0.09865191,-0.08599954,-0.0077162473,0.0064918166,0.07301737,-0.046421308,0.05133697,0.063730404,-0.00040653266,0.04465451,0.0036603145,-0.059320774,-0.07688752,0.03261802,-0.026779791,0.11365268,0.01620835,-0.006297788,0.022085598,0.049437113,0.048289787,-0.011399091,0.054857194,-0.06452047,-0.033250604,-0.0518665,-0.0054395054,0.07254708,-0.085021816,0.030433664,0.019200241,-0.04927838,-0.04618375,-0.0215043,0.02504459,0.072631866,-0.03981626,-0.051267713,0.10145168,-0.004330795,-0.021064468,-0.10892524,0.01320937,-0.06843207,-0.004687794,-0.032073133,-0.007612623,0.017785951,-0.029679433,0.008926748,-0.032625876,0.07793859,0.06512455,-0.0032112256,0.008486048,0.023541601,-0.003156538,-0.004961979,0.0021100084,0.026630044,-4.0651152e-08,0.006573601,0.016825704,0.0024460992,-0.0037873602,-0.08996223,0.030134052,0.049047947,0.022689953,-0.00086974923,0.0024917705,0.037546754,0.13322403,-0.02629244,0.053426627,0.03183132,-0.045609787,-0.055105627,-0.007407439,-0.021618715,-0.018769344,-0.036683086,-0.027322939,-0.10766264,-0.0066360794,0.05370227,-0.060242914,0.025885118,-0.00015690344,0.004803578,0.0052284333,0.06111573,-0.0005599212,-0.028831251,-0.07234901,-0.019249123,0.04224273,-0.095661126,0.000441632,-0.034041036,0.019114887,0.058948614,-0.10849376,0.0027362444,0.03800731,-0.03705641,0.06516164,0.034002975,0.07078016,-0.017274698,0.11643432,0.042117614,0.034685735,0.0008823421,-0.10207934,-0.0716852,0.029009959,0.027326183,-0.034716256,0.035385568,-0.06229629,0.08338248,-0.030726427,0.13865894,-0.045778885 +1.1.1.360,"A zinc protein. The enzyme from the archaeon Picrophilus torridus is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. It shows 20-fold higher activity with NADP+ compared to NAD+. The oxidation of D-glucose and D-galactose is catalysed at a comparable rate (cf. EC 1.1.1.119, glucose 1-dehydrogenase (NADP+) and EC 1.1.1.120, galactose 1-dehydrogenase (NADP+)).",384,1.0,-0.039391592,0.0142940665,-0.0703756,0.033557855,0.05610143,-0.008931889,-0.04739211,0.01662829,0.060170583,0.047674846,-0.015009151,0.048967298,-0.0051904707,0.054283466,-0.062649935,-0.010352565,-0.02283808,0.02630674,0.037243173,0.04959065,0.082461804,0.038540013,0.069727644,-0.019869694,0.08095742,-0.083073765,0.024561664,-0.009181121,-0.07453712,-0.027757317,-0.038001228,-0.012836231,0.0438615,0.005038842,-0.012704771,0.08586301,0.0031387128,-0.026196748,-0.0047292477,-0.03305402,0.03779323,0.06486639,-0.028880764,-0.047369827,-0.057046223,0.0109656975,0.008304011,0.042447377,-0.01713422,0.028681794,-0.069670655,-0.030602252,-0.011366127,-0.02127416,0.027087556,0.0361147,-0.021979751,-0.061142214,-0.018790158,-0.10036788,0.033544753,-0.034268234,-0.02609986,0.014349413,0.02648055,-0.09840462,0.04822877,-0.027737917,-0.059287034,-0.090084344,-0.07585314,-0.012989661,-0.04500144,-0.02459003,-0.07807284,0.08427781,0.01030478,-0.096913256,0.04030751,-0.048730347,0.058721647,0.017742116,0.00043110186,0.09089015,0.09307918,0.0056601423,0.057158638,0.052809168,-0.029771963,0.012272611,0.019634463,-0.022059845,-0.0038536007,-0.015428703,-0.11378847,0.033310935,0.019357605,-0.0018606213,-0.021209281,-0.020253737,0.029329726,0.04644233,0.08144985,-0.08315683,-0.04133547,0.07462227,0.040399846,0.13666162,-0.00026537623,0.015204608,0.028251113,-0.01435956,0.04037028,0.031851605,-0.03307171,0.072601736,0.04940724,-0.07307366,-0.11667103,-0.020817043,-0.021984244,-0.032600135,0.023845935,0.002572196,-0.041458413,0.09818446,-0.058162678,2.0846878e-33,0.082363054,0.030722886,-0.010722144,-0.010218964,0.058534965,0.06416129,-0.07507848,0.04771901,-0.00718032,0.031215461,-0.13159409,-0.043041665,0.0792239,-0.0072849514,-0.05757777,0.001348342,-0.0010945539,-0.041331165,0.071527295,0.029651534,-0.011509418,0.08656911,0.004444934,-0.04535491,0.08392234,0.009906078,-0.019489093,-0.039458554,-0.0378284,-0.026324164,0.12116364,-0.09912618,-0.11659932,0.0010703924,0.14943863,-0.00051952025,0.03346435,-0.03205583,-0.019925142,-0.07308887,-0.036106322,0.016553732,-0.05188145,-0.030714486,0.012132873,-0.0543498,-0.02098912,0.07099793,0.032388262,0.06029231,0.095131226,0.017059159,0.060808834,-0.07887845,-0.098326676,0.04426987,-0.054438043,-0.022742651,0.08138037,0.09989056,0.002076795,0.039249808,-0.045725573,0.046937354,0.010031591,0.038970254,-0.10093658,-0.03901262,-0.022245869,0.03202477,-0.031056387,-0.04214872,0.050343167,-0.0340175,-0.013328952,0.01268642,-0.008709769,-0.01782622,0.055913612,-0.012355453,-0.018973583,-0.017829156,-0.043833606,-0.011820387,-0.010276025,0.048539843,-0.018837316,-0.014546514,-0.0006604499,0.051642794,0.053707857,-0.007989104,-0.050455816,-0.031885386,0.04270378,-3.4692864e-33,0.054817352,-0.05400802,0.04919469,-0.13538338,-0.0029810325,0.07701004,0.008198818,-0.06611689,0.013240913,-0.113758594,0.084599264,0.049603518,0.01691193,-0.050022155,0.055959146,0.0045524836,-0.041713968,0.061339475,-0.026419159,-0.045875285,0.00484218,0.14308743,-0.0077458587,-0.02069347,0.03846411,0.010845635,0.011780853,0.07540278,0.0292378,0.010259824,0.04993658,0.033427324,-0.0027191148,-0.06826108,-0.024034021,0.047054462,-0.061964087,-0.014060401,0.005355052,0.013225786,0.006062257,0.010616607,-0.044732418,0.0344389,0.099784285,0.025850331,-0.16993771,-0.0497111,0.015963538,-0.0057860976,0.058961947,0.014369762,-0.016085736,0.008105766,0.11445834,0.032607842,-0.0043463307,0.02157467,-0.007273576,-0.04018905,-0.0178344,-0.012400346,0.03584169,-0.014308837,0.054748118,0.00080507656,-0.020583013,-0.015854875,-0.0035888792,-0.019149713,0.021902323,0.0478579,-0.020370035,-0.004999425,-0.010450267,-0.0046308837,-0.07589222,-0.0035966774,-0.016246725,-0.005192355,0.001600387,0.047905855,-0.008488775,-0.055311814,-0.03948436,-0.047336478,0.0060240575,0.06194061,0.0032205912,-0.016745923,-0.060242917,-0.03147326,-0.012374409,-0.0036502942,0.024054443,-4.1222613e-08,0.038553286,0.016522434,0.032046467,-0.07219736,-0.06616229,0.0017990923,0.04598336,0.0035753036,0.029542938,-0.043926943,0.10906968,0.17143546,0.028032564,0.012180775,0.029482026,-0.00815399,-0.022804528,-0.03172982,-0.035085276,0.025213016,-0.04080607,0.030722087,-0.13701269,0.067512326,0.018615304,-0.09183198,-0.02024799,-0.03721162,0.0025190022,-0.08546979,0.069370314,0.01914581,0.084642425,-0.028384602,-0.08132117,-0.0027652367,-0.024510853,-0.0084584225,-0.0067955996,0.022721777,-0.046489324,-0.057652943,-0.013078301,-0.005034465,-0.084806934,-0.001374413,0.024457168,0.03409231,-0.06187362,0.080623806,-0.008568812,0.026200827,-0.06716794,-0.081455685,-0.043611154,-0.028226668,0.006840068,-0.050919812,-0.038407654,-0.01822666,0.037203196,-0.014080974,0.12988663,-0.04928242 +1.1.5.9,"A glycoprotein containing one mole of FAD per mole of enzyme. 2,6-Dichloroindophenol can act as acceptor. cf. EC 1.1.5.2, glucose 1-dehydrogenase (PQQ, quinone).",384,0.99999994,-0.092761606,-0.06550148,-0.053611442,-0.043257233,0.058953043,0.011844296,0.048792087,0.08286267,0.039014928,-0.019214349,0.029295497,-0.039742146,-0.119451836,0.015608435,-0.03845008,0.07997703,-0.059966993,0.017556582,-0.05093286,-0.021322243,-0.0002531211,0.013843692,-0.040752262,-0.015370894,0.0015121058,0.018542109,0.033289433,-0.004424059,-0.02839391,-0.022683555,-0.012906601,0.0019758649,0.030298091,0.07156652,-0.024767151,0.10839072,0.0035274418,-0.03999603,0.0021793153,0.03681488,0.0034376294,0.0027479792,-0.017263595,-0.028288504,-0.006121999,-0.035498414,-0.039701167,0.11024013,0.007710101,-0.019902728,0.0058989283,-0.0028547787,-0.05772219,0.07453324,0.0139335925,0.07427747,-0.053634055,0.011923716,-0.058689266,0.026686389,-0.036696896,0.0007676271,-0.016151423,0.019935105,-0.00243212,-0.06477137,0.033079926,-0.06937084,0.02741383,0.0019225412,-0.0049330653,-0.052944534,-0.013408187,-0.07231049,-0.026224019,0.054968186,-0.06491646,0.01652701,0.09513055,-0.07440356,0.016843257,-0.0139036095,0.13081975,0.072728775,0.03501706,-0.068255454,0.03621612,0.03569929,-0.027495423,0.038219005,0.016621495,-0.04775236,0.0023918613,-0.07525932,-0.024961317,0.05932056,0.047923498,-0.08240727,0.028563743,-0.0033402028,0.020989839,0.03251146,0.009231793,-0.051288903,-0.13574502,0.05100203,-0.04822081,0.058177367,0.0012448643,0.0018598645,-0.041626647,-0.020675313,0.102114,0.0150063345,-0.007937371,-0.001605544,0.044908162,-0.077836655,0.053586908,-0.03675405,-0.005016279,0.03309493,0.059226662,0.045662645,-0.0154512655,0.088010244,-0.042510547,2.6810225e-33,0.04835853,0.008745968,0.021331768,-0.0052693216,-0.049376935,0.064831406,-0.076745234,0.09138085,-0.041867692,-0.087388426,-0.033281863,-0.008434324,0.020686641,0.054827046,0.030682167,0.0070791445,-0.020695735,0.02077701,0.102232374,-0.09161194,0.00041184272,0.04183033,-0.07366587,-0.01416583,0.02247904,0.05673243,-0.05756473,0.059287976,0.05445719,0.004557989,-0.002022926,-0.09660209,0.02732563,0.061505914,-0.08377282,0.06295766,-0.057923485,-0.049799517,0.00086589385,0.015983637,0.0049944473,-0.02015731,-0.00917159,-0.055643424,0.032655027,-0.016252069,-0.006625615,-0.036473103,-0.025993127,0.08015793,-0.038125984,-0.023900533,0.002029179,-0.07643702,-0.06289993,0.016230684,-0.029055784,0.03754086,0.022215262,0.04275366,-0.01384149,0.13028179,-0.05129596,0.027389197,0.0036514248,-0.019145586,-0.088613056,-0.055766307,-0.05331012,0.12196519,-0.029373849,-0.048227575,0.09568115,0.0003458809,0.009770157,-0.11130234,0.033241604,-0.024806995,-0.029492922,0.043590806,-0.055899765,-0.017612763,0.015946265,-0.0114152385,-0.09315658,0.025397742,0.015580763,-0.13000359,-0.015789947,-0.0045044604,-0.010378001,-0.07463749,-0.08413385,0.0365298,0.036079887,-3.6882542e-33,0.046608087,-0.13815157,0.09518866,0.03992283,0.038685523,0.108453535,0.015324685,-0.071162835,0.094612725,-0.026577031,0.040749367,-0.003480345,0.054076683,-0.06718481,0.018916195,0.015491948,-0.03414371,0.08502067,-0.0025067052,0.07729613,0.02575945,0.024225239,0.020005766,0.07951951,0.044288747,0.0011202431,0.030990556,-0.035713088,0.051925782,0.041494235,-0.039522737,0.04492023,-0.021176899,-0.02341241,-0.013882229,-0.03472066,-0.050381403,-0.010517748,-0.05142898,0.0514177,-0.035773903,0.021823391,0.0069706445,0.06857436,0.053056296,0.023406202,-0.011458795,-0.037851416,-0.0066259876,-0.07272614,-0.019010425,0.037390918,-0.0615504,0.05866387,0.048759587,0.044348404,0.047776744,-0.018873483,0.0050964206,-0.014731681,-0.021863386,-0.07450098,0.023895219,0.028421236,0.05671164,0.01581921,-0.037585538,0.15872392,0.036485706,0.021551099,0.11201558,-0.025669174,0.07290432,0.062617734,0.018431911,-0.038911734,-0.06533362,-0.0056216572,0.006749927,0.01810356,0.022458684,0.0386519,-0.058387384,-0.0037969693,-0.00062060595,-0.13328719,0.040661193,0.11124297,-0.075614266,0.055946536,-0.029984431,0.048088763,-0.0445549,0.07235781,0.09810935,-4.011751e-08,0.028708443,-0.11299961,0.0463419,-0.041954633,0.016528426,0.029566666,0.028796734,0.019549876,-0.02349293,0.026353963,-0.0064185285,0.055606373,-0.02576279,-0.041139208,-0.009088687,0.048278123,-0.08426636,-0.037031274,-0.02790929,0.030783497,-0.06786146,0.04702744,-0.08685028,-0.053827785,-0.004760811,-0.03553914,-0.007405978,0.025097124,-0.05184573,0.037511557,-0.013840708,0.012005222,-0.04918835,-0.053536158,-0.0051953257,0.023725243,0.040237837,-0.039893873,-0.11602238,0.027651211,0.029347947,-0.045208976,-0.031495042,-3.8210095e-05,0.002797849,-0.0023523364,-0.0039413217,-0.026674116,-0.015397357,0.019096099,0.03305096,-0.016041867,0.023109242,-0.044757947,-0.08715711,0.012046374,-0.033337623,-0.06679393,-0.06982669,-0.053389847,0.0021033383,0.043742996,0.17908789,0.030341301 +1.2.1.87,"The enzyme forms a bifunctional complex with EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase, with a tight channel connecting the two subunits [1,2,3]. Also acts, more slowly, on glycolaldehyde and butanal. In Pseudomonas species the enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). NADP+ can replace NAD+ with a much slower rate [3].",384,1.0,-0.037624463,-0.015818138,-0.046673916,-0.019847047,0.004428834,0.0136025315,-0.13170327,-0.017513823,0.021485686,-0.048001666,0.02616189,-0.11778882,-0.046071935,0.05233792,-0.035122797,0.042605713,-0.029519578,-0.0063263187,0.024630038,0.05199162,0.07986048,0.011265139,-0.040280286,0.047012452,0.039586462,0.06868844,0.06314297,0.018227536,-0.035219386,-0.064240664,-0.068036996,-0.08229539,0.0969134,-0.07365021,0.02710052,0.09870003,-0.036396474,-0.053903613,0.08855792,0.009198435,0.08200682,-0.008791943,-0.012727634,-0.05161124,0.022152439,-0.024929777,0.06992273,0.013909171,0.07737131,-0.03608928,-0.039345354,-0.019989012,-0.0071536335,0.030128025,0.014796578,0.015733792,-0.010606266,-0.0011101083,-0.034770504,-8.26819e-05,0.077407345,-0.061146423,-0.006196405,0.03162063,-0.0077046384,-0.037548225,0.06809147,-0.045355268,0.014804653,-0.049702212,-0.061928708,-0.015364502,0.008413111,0.02956141,0.08021755,-0.032474633,-0.02412564,-0.0603061,0.05925372,-0.01808057,0.03272659,-0.026755096,0.0069298795,0.033381876,0.017697744,-0.06107967,0.051708613,-0.024635037,0.0072205267,-0.019995391,-0.018946879,-0.018632188,-0.041773215,-0.049210094,-0.0072576986,0.04761253,0.05016855,0.087065145,0.060855355,-0.09471873,0.01228412,0.0720584,0.0023049247,-0.090531535,0.03255352,0.020026155,0.032909885,0.15339692,0.0088655995,0.019450078,-0.032457933,-0.06206916,0.052073985,-0.019174632,0.0071082423,0.09938843,0.008280334,-0.048906226,-0.07105865,-0.011332757,0.047296975,-0.035285197,0.04992875,0.060603686,0.0027341826,0.06546885,-0.11810541,1.9406905e-33,0.10169456,0.022329906,-0.08395228,-0.029019237,0.047167953,-0.014321774,-0.10123957,0.047184866,-0.03874426,-0.03205245,-0.0077618943,-0.015458504,0.03206062,0.0299168,-0.011682573,-0.0071563595,-0.07058247,-0.016373606,0.053871755,0.04548599,0.03644976,0.04255839,-0.032912254,0.04230336,0.05060852,0.033854023,0.045448255,0.019399242,-0.04933457,-0.0057834154,0.024181683,-0.08696319,-0.19703741,-0.049926374,0.04405859,0.011999671,-0.00921099,-0.049108844,-1.3562189e-05,0.023065927,-0.034738295,0.07193003,0.0036282095,-0.04440349,0.0659424,-0.059863053,-0.03224448,0.123943985,0.05539774,0.11719347,-0.0040551303,-0.08257564,0.099151336,0.012171414,-0.06046329,-0.005252708,0.003710989,0.04364362,0.010765166,0.0658293,0.049709756,0.10237234,-0.0093297735,0.060610987,-0.041002743,0.0067613837,-0.026933076,-0.016845832,0.04235034,-0.012904725,-0.051477525,0.048616007,0.037027102,-0.047210656,0.03366897,-0.08573797,-0.054645557,-0.00958806,-0.011756852,0.023902822,-0.00016569275,0.0002718338,0.09828376,0.0020896557,-0.040915918,0.011942417,0.022762002,0.026770314,-0.023172136,0.03343342,-0.0022226812,-0.01431213,-0.010802448,0.008472102,0.021790208,-2.25396e-33,0.12056735,-0.12659885,0.08991662,-0.04627333,-0.10081554,0.10684503,0.0014773705,-0.015091183,-0.00054744614,-0.025200969,0.10705243,0.03613976,0.068039164,-0.05229718,0.048643287,0.009708809,-0.052610923,0.031995934,-0.024571454,-0.052689075,0.034427315,0.071737684,-0.023927437,0.015640412,0.065853946,-0.00980955,-0.016063692,0.016281502,0.040953595,0.033547737,-0.04878671,0.023591818,-0.08335165,-0.0021042873,0.02113968,0.06724696,-0.093422644,0.053682588,0.050741456,0.03260033,0.050415643,0.01429516,-0.07655345,0.028586663,0.032749247,0.05859531,-0.050547875,-0.025390595,0.03313638,0.007065401,0.015331441,-0.0059754048,-0.085527025,0.021213548,-0.0049893362,0.015849216,-0.013436451,0.015299516,-0.02583368,-0.049464263,-0.08493214,-0.089572646,0.07795264,-0.017023856,-0.02069346,0.03300571,-0.033792287,0.006996966,0.046106294,0.024798574,0.07063117,-0.049597166,-0.0012463618,0.018803552,-0.0065229777,0.015608103,-0.043441996,-0.011209235,-0.006018002,0.017626096,0.07388299,0.018926838,0.046268325,-0.059003934,0.013436583,-0.006909738,0.028986387,0.10457199,-0.094987504,0.007735529,0.041281726,-0.008557952,0.00021468477,-0.012051014,0.021583345,-4.361014e-08,0.039308775,0.0029922202,0.088789694,-0.020560775,0.010355099,0.00912388,-0.04786719,-0.044958897,0.0075479955,-0.020127846,-0.01597134,0.051027406,0.014786108,-0.0018078153,0.022180367,-0.04430239,-0.04522495,0.01916079,-0.03604264,-0.012025168,-0.0787662,-0.087452084,-0.16199772,0.031075738,0.005733008,-0.049108956,0.024867317,-0.042676825,0.056363776,-0.030513449,-0.025394136,0.03360024,-0.013752383,-0.0051170522,-0.06937605,-0.044480704,-0.058337606,0.041509196,-0.06762067,0.015734944,0.051922522,-0.17732494,-0.063244335,0.010449962,0.04895232,0.042843346,0.022921871,-0.031372868,-0.0036795363,-0.0071127405,0.08833755,-0.030956738,0.042571224,-0.029220702,-0.09030115,0.045571495,0.007483961,-0.07842952,-0.0065325475,-0.011247124,0.010809748,0.012441617,0.090424,-0.055686254 +1.2.1.88,"This enzyme catalyses the irreversible oxidation of glutamate-gamma-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity [5].",384,1.0,-0.0520405,-0.08083474,-0.02233803,-0.058326263,0.06467783,0.040923897,-0.039858058,0.044880636,0.021192512,0.0362494,-0.003670404,0.039184768,-0.01879997,0.05663349,0.014159712,0.036577806,-0.05660181,-0.043347754,-0.0088891825,-0.033122476,0.012421121,0.023430234,-0.061705057,-0.027055519,0.05677319,0.031808708,0.09543963,0.035562545,-0.09575397,-0.08617816,-0.018030701,-0.064209945,-0.017274594,-0.0005282628,0.034119274,0.083120055,-0.13131148,-0.04844538,0.06885352,-0.02872897,-0.019160278,0.042069864,-0.07950537,-0.07773246,-0.036600675,-0.03825966,0.032070495,0.02119552,0.020398494,-0.052092344,0.01028929,0.065413564,-0.002285759,0.06304103,-0.028497651,0.016522866,0.014259647,-0.031850915,-0.058123954,-0.022902926,-0.04915139,-0.045687877,0.0049557346,-0.08074279,-0.0023526577,-0.027174555,0.058129884,-0.048053198,0.021190649,-0.025642993,-0.16391578,-0.047930915,0.032565523,0.052305736,-0.031175604,-0.031630408,0.008553731,-0.031349953,0.053628046,-0.049886994,0.01948849,0.012254652,0.037779566,0.036059484,0.03969564,-0.03761779,-0.021475062,0.050361935,0.06911697,0.036498513,0.008000664,0.03553065,0.010819612,-0.013436374,-0.056302436,0.005989432,-0.038839273,-0.011647091,0.015754187,-0.07750222,-0.0041055516,0.08437797,-0.0024094316,-0.078097165,-0.02536486,0.053036474,0.041907214,0.09457546,0.0064606643,-0.018664481,0.005035957,-0.04505861,0.04662162,0.029679917,-0.032786395,0.051919304,0.004842043,-0.030934364,-0.081320025,-0.019984277,0.031390358,-0.015982479,0.09667116,-5.921711e-05,-0.042762265,0.057621498,-0.05807904,4.501148e-33,0.009190112,-0.0064190095,-0.035385106,0.00013906627,0.049645737,-0.0030865239,-0.0959316,0.08384025,-0.0055685374,-0.034118183,-0.045116276,-0.09272135,0.037015516,-0.026377492,-0.0034042364,0.0051486897,-0.0719965,0.003797926,0.009326854,-0.011757473,0.014785079,0.102138504,0.021024909,0.010723016,0.026444143,0.031742252,0.033799008,0.059807062,0.0081463605,-0.025014592,0.05329513,-0.1377124,-0.115527235,0.034150142,0.058447033,0.014512016,-0.015227787,0.005868662,0.030667845,0.09994163,-0.035136405,0.038389355,-0.03161935,0.0039534727,0.04927006,-0.07924017,-0.009612576,0.14538112,-0.028849585,0.08236601,0.05375258,-0.02919453,0.101245,-0.09362576,-0.050311293,0.059088644,-0.01652654,-0.0010500622,0.07847223,0.063468434,0.031613547,0.054399014,-0.06379376,-0.019797724,0.055695903,0.04294252,-0.026331749,-0.09185405,0.023774497,0.023483584,-0.03882853,0.04931614,0.102722555,0.03809484,-0.012122963,-0.006382275,-0.06475768,0.03722376,0.06375623,0.0036011431,-0.08581011,0.03019832,-0.003860217,0.021319166,-0.020097457,-0.015397711,-0.003552463,-0.08379787,0.00450495,0.04954102,0.039440922,-0.08479482,0.0026513264,0.029790377,0.032854468,-4.0356007e-33,0.10174571,-0.05775135,0.03995957,-0.02963968,-0.030972434,0.104855984,0.014869252,-0.047944054,0.048249714,-0.00503735,0.033432618,0.094096124,0.052659217,0.025492642,0.05886976,-0.012293281,-0.05294226,0.08351037,-0.06765331,-0.03050561,0.09865872,0.08034409,-0.015552311,0.040790547,0.037744183,0.023558881,0.040128477,0.022719111,0.07549041,0.04799367,0.038043097,0.03907987,-0.020196682,-0.0827773,0.004818612,0.047417972,-0.08388571,0.031905893,-0.028284285,0.057508104,0.022058103,0.06629744,-0.013273476,-0.04684236,-0.025250852,0.04349803,-0.08437394,0.0023832447,0.012248484,-0.040760305,0.025757058,0.018106166,-0.062457412,-0.048201103,0.03233786,0.023466641,0.028889943,-0.01526314,0.0039486755,0.010038312,-0.06152671,-0.080536775,0.09674535,0.014304034,0.009480584,-0.016725468,0.052066207,0.024694482,0.07873929,-0.031803526,0.0762544,-0.0037201284,0.035325788,0.014671415,-0.010170324,0.053964406,-0.010306476,0.0024723732,0.04410091,-0.017723972,0.06544389,-0.063378565,-0.031709194,-0.095055364,-0.034842458,-0.08886193,-0.016487332,0.13090678,0.060389988,0.019295609,-0.020751104,-0.03933842,-0.0009630374,0.05114908,0.05101264,-4.696887e-08,0.010859799,0.010344221,0.07621635,0.013394837,0.013011901,0.039499264,0.046076737,-0.049127854,0.08099942,-0.054731276,0.012100206,0.0722197,-0.051361687,-0.027996663,-0.013203426,0.011630703,-0.044157095,0.030594343,-0.016211882,0.0019416591,-0.08278155,-0.042969093,-0.14781061,0.019502332,0.0689455,-0.07495976,-0.005356934,-0.00274184,-0.026874065,-0.0448881,-0.039568365,0.07761601,0.05917664,-0.06558088,-0.04427818,-0.0640616,0.003542939,0.04539797,-0.05579992,0.06563817,0.020049404,-0.06539665,-0.06431392,-0.05157448,-0.031212198,0.048915494,-0.016069138,-0.0068218815,-0.087070875,0.009974818,0.04147057,-0.020929663,-0.016517574,-0.021256523,-0.115750045,0.07332259,-0.013350964,-0.090693,-0.038179483,-0.05714473,0.022754287,0.046606246,0.11093194,-0.036224216 +1.3.1.102,"Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde [3]. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones. Has very low activity with NAD as reductant (cf. EC 1.3.1.74, 2-alkenal reductase [NAD(P)+]).",384,0.99999994,0.024172658,-0.09035071,-0.0364727,0.041428972,0.052720886,0.036143817,-0.00084850646,-0.008513952,0.05584822,-0.0013743432,-0.03801693,0.03548319,-0.052714977,0.04401455,-0.0513342,0.05805226,-0.020132031,-0.036205463,0.019807586,0.02680378,-0.094554126,-0.0032552574,0.051460247,-0.01688657,0.076733164,0.0080515435,-0.024929978,-0.04526517,-0.038674653,-0.11772576,-0.0052526877,-0.000662697,-0.0041620275,-0.039889976,0.020964636,0.05439878,-0.11785004,0.01367584,-0.0491883,0.015847819,-0.013140802,-0.04313185,-0.0595021,0.03262974,-0.002031089,-0.019663896,-0.07606788,0.046367392,0.034889072,0.016157402,0.028592093,-0.035547018,0.03917696,0.0984277,0.07823489,-0.055802796,-0.06779097,-0.0042113685,-0.008198765,0.033848632,0.08174916,-0.02629898,-0.035703782,-0.023441484,0.031065138,0.0068846988,0.0984022,-0.08894697,-0.025192373,-0.069303825,-0.12015697,-0.044440262,-0.020131256,-0.03872791,-0.010708665,-0.0088751055,-0.02181112,-0.028847562,-0.024343304,-0.007858687,0.054804265,0.017644655,0.026581455,0.049488302,0.106255844,0.018495897,-0.0688323,-0.006408658,-0.03864461,0.047442157,-0.023758037,0.052775875,0.019030035,0.0106965145,-0.037754405,0.022787683,0.016187267,0.060849626,-0.028868245,0.022024663,-0.0048049884,0.102702774,-0.07649817,-0.06340392,-0.12410149,0.06298356,-0.0018064221,0.021832805,-0.017284863,0.031891454,0.03032023,-0.0051496276,-0.049164064,-0.02866313,-0.060931366,0.08257737,0.05734431,-0.025007555,-0.087883174,0.024790838,-0.05280069,0.010365103,0.05520383,-0.024492573,-0.08952128,-0.012116939,0.036167994,2.9491756e-33,0.038446613,0.043276485,-0.03635792,0.051114354,0.08108313,-0.018058313,-0.14833243,0.031513713,0.07579653,-0.06674077,0.022270463,-0.02926563,0.030656276,-0.06779216,0.0032107013,0.049826235,0.01387582,-0.049026143,0.028452551,-0.072881415,0.0142114675,0.009631506,-0.049632527,0.016822588,0.035784617,-0.02188857,-0.0841663,0.02397313,-0.018262988,-0.0305443,0.013353889,-0.077952854,-0.073994525,0.020967541,-0.00087433733,0.0049598925,-0.066230305,-0.009761026,-0.013689186,0.05315319,-0.052263577,0.030320784,-0.0091357045,-0.04623559,0.04637648,-0.06459618,-0.026604911,0.084555425,0.045200422,0.058199458,0.054051477,-0.03156037,0.037707794,-0.058752615,-0.05023152,0.0697488,0.026060507,-0.019128406,0.015621391,0.10643619,-0.02344744,0.020997785,-0.014700449,-0.036391415,-0.07897876,0.042056173,-0.12973945,0.0008216649,-0.033673197,-0.004889283,-0.027840761,0.06606746,0.13406307,-0.04245487,0.023454895,0.029901827,-0.045470223,0.033220567,0.050086793,0.02211447,0.038097367,-0.028682387,-0.02305598,-0.021910077,-0.03707611,0.031892665,-0.022431957,-0.05901588,0.03136034,0.033661753,0.06435584,0.0039965543,-0.08270131,-0.086561404,0.0651409,-4.336062e-33,0.09378926,-0.058216672,0.033963475,-0.13620546,0.0613533,0.10278296,0.012720388,-0.017769136,-0.007594994,-0.013085565,0.07110874,0.07799028,-0.032553166,0.009322101,0.028564654,-0.062596165,0.022117702,0.059001733,-0.015349429,-0.049884867,0.0064624143,0.0919444,-0.02242247,0.037455678,-0.0043748515,0.010370367,-0.031100858,0.024746768,0.12735929,0.026492424,-0.0066091754,0.021454832,0.0004328822,-0.024010727,0.08515822,0.097042896,-0.09030846,0.03630592,-0.104019806,0.065572254,-0.008235079,0.025071405,-0.10150067,0.0262945,0.11166176,0.07765657,-0.14337702,-0.03750212,0.02117751,-0.07095864,0.11720498,0.04930681,-0.06076248,0.05391759,0.0662579,0.06536755,-0.049208768,0.015108789,0.090867534,-0.010795309,-0.027940253,-0.0052538747,-0.031660877,-0.01177372,0.0075735427,-0.09375273,-0.039327092,0.085479856,0.0069942535,0.0278638,-0.004388592,0.01637083,0.013685158,0.035279386,-0.09967108,-0.047558546,0.04841344,-0.05280489,-0.001612985,-0.007365173,-0.008759832,0.015009246,-0.033814587,-0.064120986,0.022040758,-0.015338098,0.006466829,-0.00372024,-0.039455842,-0.03910206,0.010245568,0.05657506,-0.07987626,0.03468639,0.015988953,-4.3511054e-08,0.08825797,-0.0019867592,0.022499392,0.0073788147,0.011824718,-0.007583433,0.0798563,0.04521626,-0.008755729,0.005806118,0.0025438769,0.101559214,0.073485315,0.00920709,0.012063774,-0.019748773,-0.045308378,-0.032732867,-0.0020385042,-0.0160529,-0.028070658,0.02970846,-0.037335962,-0.014586543,-0.06346323,-0.07017242,0.037263248,0.002101337,-0.01688357,-0.060390685,0.035236154,0.061216198,0.055976074,-0.042165477,-0.037875295,0.029835423,0.028776946,0.042931475,-0.054665446,0.050655685,-0.07017112,-0.06194745,-0.08368058,0.04467604,-0.03967176,-0.018581467,0.015827475,0.0007156352,-0.008484215,-0.028068075,0.05712552,0.013075801,-0.046406474,-0.00057910103,-0.09440465,0.03462364,-0.030219426,0.016659698,-0.021707423,-0.11002814,0.059869934,-0.042783357,0.0687917,0.0049597886 +1.3.1.103,The enzyme acts in the degradation pathway of unsaturated organohalogen compounds by the bacterium Burkholderia sp. WS. ,384,1.0,0.026810963,-0.051167734,-0.081683844,0.014911793,0.039172664,0.05080268,-0.085060015,-0.010467429,0.018749602,-0.08332874,-0.018186707,-0.055587526,-0.057184022,-0.03073642,-0.05845729,0.090997964,-0.06153486,0.022832474,-0.021286666,0.08663103,0.11620181,0.052589547,-0.051934507,0.08943056,0.027801953,0.055415,0.0907788,-0.052005004,-0.009945527,-0.07579382,-0.07389812,0.009293401,0.10761881,-0.06024635,0.09908532,0.13193242,-0.047152434,-0.038483664,0.0883054,-0.054695394,0.021863965,-0.014707928,-0.05540607,-0.028412296,-0.0023536684,-0.013324691,0.0068798573,0.03826247,0.05832339,-0.05752738,-0.060020957,-0.025696944,0.012915525,0.019302202,-0.009596619,-0.028896559,-0.015358421,-0.0079148,-0.071231246,0.020175181,0.07170355,-0.012415163,0.025323393,-0.018456815,-0.021679204,-0.029695813,0.045981713,-0.060196746,-0.004429637,-0.047621857,-0.1061438,-0.036137074,0.008047675,0.021177359,0.037228514,0.033243988,-0.024633376,-0.07296963,0.008254193,-0.036362734,0.09577521,-0.05415043,0.017261231,0.04406883,-0.021375647,-0.009020572,0.01895536,-0.017853169,0.019675935,0.023800932,0.060821805,0.04101316,0.07429282,-0.08966623,-0.013675243,0.03997373,0.04601204,-0.0045221043,0.094762,0.008926335,-0.06280849,-0.0033397428,-0.036843937,-0.095985845,-0.04942846,0.0012373034,0.032142013,0.07448936,0.0962889,0.021409735,-0.0061265514,-0.0166205,0.06298941,0.010876401,-0.03720701,0.06332258,0.03958723,-0.041240115,-0.12110108,-0.016669909,-0.025602305,-0.05064382,0.005117298,0.014296186,-0.041065272,0.006110556,0.023233043,-5.8598916e-35,0.0800836,-0.0029260975,-0.039370414,-0.053337928,0.011727542,-0.06656825,-0.038362093,-0.043568496,-0.019684615,-0.05372284,0.0045455536,-0.05564833,-0.07119174,-0.058983378,0.05123127,0.021356184,-0.016964091,0.10073672,0.08311069,0.042418737,0.009842076,0.044328965,-0.09842588,-0.029523842,0.01470014,0.0563093,0.042172316,0.022175018,-0.00867217,-0.032003235,0.10117895,-0.0036169924,-0.17480364,-0.04884349,0.032857273,-0.0333986,-0.03243076,0.005117234,-0.02476119,-0.018965833,0.043082774,0.03668273,-0.0382745,0.0010423383,0.072732665,-0.096171,-0.043283835,0.120723665,0.06796323,0.06660808,-0.044497646,-0.03117793,0.03797648,-0.012975162,-0.02168926,-0.0062384624,0.06264481,-0.011988237,0.019209621,0.019124847,-0.031187592,0.10997037,-0.022547876,-0.0010015649,-0.032646812,-0.046073947,-0.05662565,0.040892314,-0.015880197,0.026463611,-0.008901975,-0.033751752,-0.01626233,0.051646996,-0.04445035,-0.0675927,-0.047414865,0.02967462,0.019204056,0.005261117,0.015539651,-0.0018631719,0.06686495,-0.01641443,-0.042391572,0.029394843,-0.029789994,-0.04457659,0.012090113,0.014085292,0.07553928,-0.052381676,-0.06017549,0.0534027,0.024738848,-1.0179221e-33,0.15422408,-0.08049348,0.028551206,-0.021054035,-0.09081697,0.019958904,-0.09290159,0.060250055,0.019131273,0.01577027,0.09100991,0.012443768,0.017216628,-0.02774894,0.052428953,0.0044552395,0.07061813,0.060469586,-0.07768694,-0.059651628,0.001443207,0.06990233,-0.0048545417,-0.024286598,0.02496433,0.010723448,-0.009826612,0.08151204,0.006221956,0.047191814,0.051788382,-0.0011307574,-0.052771866,0.024527518,0.00927644,-0.02218035,-0.07669821,0.002192185,0.017241929,0.0340394,0.03506634,0.02484216,-0.055340312,-0.02203887,0.020484772,0.01272075,-0.052066553,0.00400971,0.10009582,-0.06262428,0.066277504,-0.005272871,-0.0009868384,-0.028809857,-0.01746352,0.049040373,-0.011065102,0.009916902,-0.0396416,-0.048785344,-0.03534841,-0.014072345,0.045760076,0.029462798,-0.0371465,0.04094706,-0.039051183,0.04346537,0.035553012,-0.07048867,0.036663663,0.00989635,0.04106931,0.08467525,-0.03290206,0.046741445,-0.076903924,-0.060548477,0.023756575,-0.014233342,0.03696604,0.0087526245,-0.025333954,-0.081915535,-0.012069866,-0.040980116,-0.0146857845,0.037058674,-0.06512869,0.06290262,0.011974974,-0.057005905,-0.025711196,0.057913836,0.05055376,-2.5408438e-08,0.04013661,-0.0091740545,0.027812803,-0.011739812,-0.009040605,-0.03316783,-0.018333921,-0.018549994,0.09419017,-0.013432626,-0.09195437,0.010841815,-0.030831227,0.020977262,0.023598922,0.015253733,-0.03643769,-0.0054127746,-0.039083906,0.033171874,-0.056454644,-0.09672063,-0.045147173,0.05325987,0.06306758,-0.04152854,0.11872721,0.0330543,0.03955965,0.0133090895,0.014328231,0.046545085,0.008499343,0.04480862,0.0068915267,-0.0023679265,-0.047296125,-0.0055747754,-0.10265546,0.12713625,0.019351736,-0.03639287,-0.12091766,-0.040528174,0.020125033,0.01887921,-0.024592666,0.09602325,-0.009906,-0.047402527,0.058187284,-0.050017465,-0.026582345,0.0075499862,-0.07560461,0.031754456,0.06687992,0.009367321,-0.02737321,-0.023716148,0.038603153,0.01689726,0.18273605,-0.0653131 +1.6.1.3,"A flavoprotein (FAD). The main function of the enzyme is to oxidize excess of NADPH, forming NADH that supplies electrons to the respiratory chain. cf. EC 7.1.1.1, proton-translocating NAD(P)+ transhydrogenase. This entry stands for enzymes whose stereo-specificity with respect to NADPH is not known. [cf. EC 1.6.1.1, NAD(P)+ transhydrogenase (Si-specific)].",384,1.0,-0.072803676,-0.034996767,-0.09096727,-0.007956657,0.09128985,0.042634994,-0.011377273,0.079349,0.04403542,-0.0032101297,-0.03324645,0.05443233,-0.14195238,0.02440276,-0.060581684,0.020080358,-0.07793092,0.02052962,-0.04041889,-0.05142414,0.016678117,0.02329598,0.0768919,-0.068162754,0.024430139,-0.020068578,0.00143233,-0.04034914,-0.02142446,-0.011558542,0.060028404,0.036462188,0.021185217,-0.008797657,-0.09464677,0.0848527,0.023514397,-0.023617432,-0.022212682,0.026568186,0.0502706,-0.026212549,-0.02559871,-0.013838968,0.055226237,-0.008922886,-0.002694977,0.05031684,-0.010774062,0.043456286,0.00475449,-0.012239568,-0.08645709,0.04610504,-0.013456324,0.029739449,0.051266428,-0.09648045,-0.03926305,-0.026462883,-0.021775754,-0.055739157,0.015837999,0.048413657,0.08686274,-0.09416599,-0.0007018835,-0.028207567,-0.0067966245,-0.011924867,-0.07530034,-0.015428041,-0.036260758,0.0114027,0.021758277,0.03338148,-0.10347962,-0.041723784,0.044503633,-0.003562014,0.14594142,0.02379274,0.04547709,0.057179455,0.087619655,-0.006624256,-0.028409064,-0.0010201419,-0.06329571,0.060485803,-0.021235846,-0.040860146,-0.021690723,0.03198435,-0.109456845,0.054640137,0.05096254,-0.044369664,-0.031886425,-0.031000355,-0.032277755,0.053867422,0.04597951,-0.032206386,-0.072706535,-0.06838552,-0.06239156,0.11040496,-0.039074633,-0.016281331,-0.017890964,-0.035672817,0.0299542,-0.07261168,0.026645536,0.079953,-0.010012898,-0.04010055,-0.007061824,-0.056049235,-0.035090707,0.08641422,0.030296449,0.110073216,0.061386395,0.025620587,-0.12148904,1.0912652e-34,0.10716014,-0.0070726424,-0.04843531,0.016047012,0.005237806,0.028077602,-0.0429243,-0.0007153116,0.019777002,0.0079704095,-0.009184205,0.004053045,0.033099055,-0.042504337,0.033040553,0.028483285,-0.040782195,-0.018698374,0.06539254,-0.080414556,0.044275746,0.047604673,-0.01881567,0.05918612,0.054329038,0.017329933,-0.0918981,0.08456015,-0.039881792,0.015190175,0.007992363,-0.050873913,-0.09862019,-0.012554101,0.024475507,0.012180801,-0.09910524,-0.080326356,-0.08264867,0.049437005,-0.019019777,-0.01361493,-0.0094649745,-0.001732564,0.024837099,-0.077568136,-0.047081195,0.10924587,0.028853672,0.09105368,0.025599822,-0.050325062,0.098280616,0.046569034,-0.055924647,0.046157874,-0.06843715,-0.06882221,-0.033317078,0.014678181,0.029117484,0.019397093,-0.03633242,0.14382336,-0.112215646,0.018281076,-0.013638987,-0.094252266,0.03375886,0.1264801,0.011211375,-0.0032995834,0.06988916,-0.022130616,0.056475997,-0.004097145,-0.012872584,-0.05306135,-0.03755764,0.0175846,0.013600391,-0.01390424,-0.018682832,-0.014243109,-0.02017661,-0.012463111,0.0022710008,-0.07585531,-0.015188819,-0.010478344,0.039610412,-0.030290028,-0.016415548,-0.0007014514,0.058195483,-1.4657032e-33,0.04074078,-0.054474078,0.054396942,-0.03124689,-0.028987268,0.073430866,0.06333861,-0.07072939,0.006172616,-0.0419634,0.015706228,-0.021272333,-0.01843232,-0.02077045,0.052888464,-0.0057070907,-0.07935074,-0.013309879,0.035012003,0.023445025,-0.039084293,0.09683211,0.052595407,0.06459868,0.04455069,-0.048710786,-0.025941443,-0.041499097,0.030439528,0.02690211,-0.023378488,0.035278156,-0.0861617,0.017625552,-0.054841284,0.008286161,-0.014794639,0.04689084,0.01419055,0.069906004,0.023465266,0.00089652557,-0.020697404,0.013554762,0.06167007,0.037621632,-0.056155797,0.015101719,0.068390556,-0.06007595,0.028254211,0.05571133,-0.00607036,0.04767062,0.075064346,0.061467092,0.0041046017,0.04859609,0.018622389,-0.007988233,0.011889821,-0.10517851,0.014532706,0.0028514215,0.058985155,0.0407571,0.044897076,0.06239453,0.030457415,0.02332636,0.095964886,-0.011197898,0.034727994,0.085286014,-0.0065454557,-0.072185345,-0.058087695,0.061642013,0.00021235978,0.0574809,0.024150725,-0.003446117,0.0031189409,-0.014630848,-0.07344956,-0.09466734,0.016113857,0.08156277,0.00891178,-0.01400193,-0.031170532,0.073279195,-0.043107964,-0.026022207,0.03363299,-4.0988176e-08,0.027636155,-0.04427729,0.00040153306,-0.0508219,0.039950103,0.02971204,0.0060450914,-0.04834016,-0.014065019,0.006141137,-0.061330616,0.14824903,0.038251616,-0.0009422782,0.08332001,-0.03868732,-0.023907784,0.035338033,-0.039250594,-0.040062655,-0.065730736,0.05949742,-0.14354816,0.040139724,-0.03965637,-0.038803197,0.011270573,-0.0076305536,0.035444595,-0.0024303985,0.014651252,0.012664489,0.04549184,-0.005324033,-0.12630183,0.063271895,0.03608327,-0.05434818,-0.040215373,0.06249561,-0.07633994,-0.0518704,-0.013256277,-0.014412426,-0.028058669,0.016603475,0.04985864,-0.02387574,-0.072602,0.039109074,0.037702527,0.0010888753,-0.01091676,-0.029484248,-0.04506146,0.011631583,-0.028739905,-0.113034874,-0.028781895,-0.058071557,0.012145517,0.048328783,0.10901138,-0.0422106 +1.8.1.18,"This FAD-dependent enzyme, characterized from the archaeon Pyrococcus furiosus, is responsible for NAD(P)H-linked sulfur reduction. The activity with NADH is about half of that with NADPH. The reaction is dependent on CoA, although the nature of this dependency is not well understood.",384,1.0,-0.062036347,0.02708822,-0.04425497,-0.04818134,0.07926625,0.07751004,-0.07722155,0.04177482,0.05415716,0.048206024,0.00035935806,0.042433634,-0.09764037,0.071253754,-0.049572174,0.015077697,-0.09158322,-0.01056769,0.020359965,-0.0061009675,0.06468464,0.026390072,0.053129975,0.0041765836,0.008539461,0.014861591,0.048494373,-0.012423455,-0.005141233,-0.04245004,-0.018893719,-0.0044657756,-0.0039003869,-0.065516464,-0.0073523256,0.08044072,-0.021686114,-0.0043043294,-0.00527656,0.00880781,0.049170878,-0.015383493,-0.032927923,-0.0335426,-0.04992087,-0.0099337185,0.03776096,0.04084363,0.0045211934,-0.044680625,-0.022993937,0.0011375054,-0.066273324,0.016131561,-0.007143257,0.043554332,0.01776717,-0.061321523,0.0007092754,-0.10529914,0.008182103,0.010617874,-0.04751545,0.027191974,0.05917098,-0.039898008,0.05273746,-0.04149996,-0.0233594,-0.06590902,-0.06216167,0.004045424,-0.0036667367,-0.0326796,0.007913135,0.08655902,-0.060145337,-0.1021779,0.04784499,-0.038820576,0.06748246,0.025555681,-0.0028002604,0.07613319,0.03733684,-0.03748855,0.037847284,-0.024071831,-0.016588261,-0.046258695,0.002674411,-0.0868235,0.001594927,-0.021439848,-0.13732673,0.054581422,0.058883954,0.041778345,-0.012165306,-0.01019673,0.0028853181,0.06577882,-0.04639892,-0.08776932,-0.09305487,0.01158988,-0.039938316,0.14746007,0.047391348,0.011472413,-0.06984741,-0.020188492,-0.07182557,0.0024577896,-0.03680266,0.083586216,0.06871187,-0.06614714,-0.11572787,-0.02913008,0.011106734,0.02149522,0.066568226,0.0651518,0.007887141,-0.0115904035,-0.13644604,9.071312e-34,0.12347628,0.04158533,-0.0001858479,-0.08601983,0.07643185,-0.026681712,-0.1282342,-0.0010785783,-0.043892644,-0.0050395317,-0.065660395,-0.035832502,0.03505673,-0.044722967,-0.026939996,0.011321628,-0.031435773,-0.004772747,0.022816323,-0.024703031,0.017583622,0.10304555,-0.008003406,0.028233998,0.04792735,-0.0056001693,-0.020235308,0.07209806,-0.025770845,-0.007955147,0.06541196,-0.10022602,-0.10771377,-0.01703622,0.07211689,-0.03827603,-0.10441361,-0.046164885,-0.043425184,-0.024106706,-0.03612808,0.0007613763,0.01485207,-0.04156015,0.03863063,-0.14524843,-0.007075815,0.07032713,0.010544855,0.083283074,0.046806287,-0.03192143,0.07913154,0.021101655,-0.065400116,-0.022301741,-0.029411435,-0.057265118,0.01704929,0.03243698,0.13322924,0.024607033,-0.031688202,0.09081314,-0.049400274,5.2595888e-06,-0.021257007,-0.033029146,0.047813438,0.10748018,-0.038710438,0.020955896,0.027332783,0.036735285,0.023013046,-0.01655217,0.025340024,0.009729752,0.03532122,-0.012051592,-0.0063910163,-0.05309534,0.038692277,0.0016774795,-0.048397608,-0.0039577526,-0.005850989,-0.032943275,-0.037838895,0.05496928,0.05582838,-0.060504872,-0.004972515,0.0009295864,0.044075657,-2.0309517e-33,0.044815857,-0.041590262,0.07420572,-0.15786918,-0.06947192,0.09691766,0.08123991,-0.01554748,-0.009256731,-0.065244794,0.06683681,0.013889514,0.025606707,-0.013016035,0.08303236,0.010813836,0.00878595,-0.027871508,0.03325638,0.033779133,0.014749519,0.094225615,-0.0373723,-0.019058539,0.035381895,-0.04383396,0.017235776,0.049475085,0.04061291,0.05425287,-0.00034882396,0.032518897,-0.062683314,-0.03587022,-0.03215229,0.0008203788,-0.03802023,0.042096537,-0.020492932,0.0208288,0.037211344,-0.03063032,-0.017773744,0.037491202,0.07452521,0.04056965,-0.10471054,-0.010624681,0.035205483,-0.03980372,0.03182002,0.046563827,0.04152602,0.01219407,0.084740914,0.034330938,-0.030237013,0.022730017,-0.0011762665,-0.0118341,-0.009384285,-0.05383756,0.0072900658,-0.007476185,0.07250875,0.0052654394,-0.04191678,-0.009197991,0.03577705,0.014321092,0.08223681,0.078135476,0.0049927374,0.009745639,0.0056637046,-0.05454563,-0.031376377,0.031572,0.02949884,0.021479791,0.0044899518,0.03795093,-0.047836047,-0.09783885,-0.040557887,-0.06967586,0.04294533,0.068133384,-0.02444538,-0.019949647,0.033924326,0.06614883,0.006968236,0.027563859,0.017157659,-3.2477384e-08,0.011261788,-0.016955897,0.01446746,-0.0047684135,-0.0028852827,0.018450415,0.041499298,-0.035440106,0.006694529,-0.010499177,0.0029897827,0.12516312,0.10842522,-0.028876703,0.048546012,-0.018812826,-0.06052267,0.01778469,-0.04038215,-0.058369465,-0.04050741,0.0050660577,-0.12493391,0.07490001,0.03880469,-0.035042685,0.05725903,-0.034481,-0.06495616,-0.06444232,0.06867451,-0.004812606,-0.00805372,-0.038251188,0.011845333,0.067499265,-0.007971371,0.007842379,-0.027038325,0.039295617,0.018790362,-0.022600917,-0.038269337,0.035450466,0.050112396,0.05003794,-0.01703765,-0.015439758,-0.075302646,0.035044696,0.06248375,0.037856527,0.0071129766,-0.09609494,-0.11175578,0.011650194,0.06210936,-0.08641795,-0.08186329,-0.06090227,0.119620994,-0.030979916,0.08626414,0.013995243 +1.10.3.13,"A copper-containing cytochrome. The enzyme from thermophilic archaea is part of the terminal oxidase and catalyses the reduction of O2 to water, accompanied by the extrusion of protons across the cytoplasmic membrane. ",384,0.99999994,-0.09667207,0.0075250315,-0.03367791,0.045433022,0.08619703,-0.012480327,-0.0015642173,0.006609991,0.040569067,-0.03798533,0.007679721,-0.08752698,-0.01807731,-0.008147186,-0.08142921,-0.020863332,-0.05385455,0.005784346,0.0054942016,-0.021726858,0.02010596,0.059764106,0.03343018,-0.004730985,-0.03096465,0.08089859,0.023181466,-0.036433376,-0.054509953,-0.017801793,0.009404473,-0.014100293,0.070938066,-0.015106672,0.03292263,0.06574318,-0.0035164189,-0.016742192,-0.025993163,-0.067398,0.05307546,0.0731191,0.06733488,0.060468014,-0.01836258,-0.0054010185,0.08975415,-0.052761633,-0.009287484,-0.033755157,0.035528596,-0.0758504,-0.10112392,0.065919235,0.020497655,0.08150287,-0.016070314,-0.14313316,-0.032484073,-0.029233633,0.058065396,0.05324754,-0.0653857,0.086859815,0.043620158,-0.06737194,0.050494794,-0.021798404,-0.02710448,-0.036474288,-0.032090273,-0.028236499,-0.039541055,-0.024250088,-0.047590584,0.05554479,0.11345731,-0.091530174,0.0834247,-0.0028040789,0.027020328,-0.010835837,-0.023628363,0.065179095,0.05676673,0.014505791,0.072486855,-0.028572224,-0.01304568,-0.07957575,-0.0012308114,-0.0154824555,0.012245354,-0.057659,-0.06310009,-0.011618346,0.059259277,0.0159553,0.021267476,-0.006914202,0.010880165,0.10887695,0.043407127,-0.11813097,-0.03647782,-0.035410423,-0.042945504,0.12684073,0.07133226,0.010770694,-0.02422555,-0.072245695,-0.00010962858,0.018830765,0.04967501,0.03249433,0.044794317,-0.053387973,-0.07118559,0.0718126,-0.082527,0.0065782918,-0.010727315,0.036384083,-0.045738757,-0.0016486248,-0.09711388,1.75629e-33,0.040133774,-0.026379498,0.0087480275,-0.061950732,0.09969503,0.03186197,-0.05458992,-0.018793888,-0.014900254,0.032103088,-0.078638144,-0.003152492,0.013159713,0.024518838,-0.015344929,-0.0038567253,-0.058469784,0.029309427,0.04123823,0.0032173477,-0.040362857,0.058448296,0.006166031,-0.021912795,0.06671866,-0.0010120377,-0.035964426,-0.057082873,0.03411456,0.00037872238,0.0064355913,-0.078157455,-0.119120784,-0.005582829,0.07217892,-0.03175504,-0.0053810757,-0.025158342,-0.026438246,0.06503718,-0.05761948,-0.0011451364,0.027308112,0.011605257,0.03038422,-0.086156264,-0.0975057,0.15428837,-0.012371106,0.053307198,0.022411434,-0.067663096,0.08612741,0.013332265,-0.099471174,-0.014908359,-0.05546736,0.05084238,0.021728626,-0.00025163346,0.016096398,0.1014114,-0.056482915,0.07312019,0.028078828,0.03969693,-0.01135687,-0.022734609,-0.00032943225,0.08688884,-0.12081881,0.0012010962,0.025615111,0.025467584,0.04355495,-0.025892075,-0.08184765,-0.04494019,0.0127667375,0.063162036,-0.06326548,-0.051696543,0.035081577,-0.0130066285,0.023445437,-0.0041544344,0.0026458045,0.03323914,-0.016093576,0.03577243,0.030991318,-0.062013634,-0.034545694,-0.019986305,0.0008568065,-3.2106615e-33,0.049783822,-0.11095984,-0.00987622,-0.13759075,-0.029913798,0.01112731,-0.03523052,-0.039957933,-0.00907192,-0.033042308,0.07470751,0.022926513,0.046430077,-0.049668208,0.039621815,-0.079687886,-0.014311053,0.115346506,0.0573165,0.031707697,0.010005078,-0.013672751,-0.026067372,-0.041009266,0.03836246,0.0009466133,-0.009980032,0.019682623,0.0662262,0.022776917,-0.05408615,0.07568973,-0.0352662,-0.046197582,-0.07751804,0.08364518,0.015231834,-0.010305256,0.06436173,0.053750243,0.041520793,0.04789185,0.008405604,0.0924813,0.029075293,0.04809206,-0.10313163,0.026873183,-0.012421017,0.030828089,0.052912883,-0.02923906,-0.0032439772,0.025386585,0.04972194,0.056092154,-0.051604487,-0.03469754,0.0077067036,-0.035029538,-0.023845358,-0.071573354,0.0018577299,0.027807925,0.006690629,0.0435204,0.015862275,0.087922074,-0.017203638,-0.040157437,0.057480715,0.027062695,-0.014593277,0.015676124,0.03589258,-0.02186713,-0.013097169,0.007224497,0.07262164,0.005740015,-0.011478269,0.049791016,0.042762186,-0.06233769,0.02940713,-0.10235894,-0.020414254,0.098986775,-0.014603953,-0.04067024,-0.012996503,-0.045826014,-0.03620423,0.05547774,0.015161993,-3.181711e-08,0.04149327,-0.022747181,0.08068414,-0.050617293,0.0085814195,0.07120574,0.061095204,0.025014305,0.019194981,-0.028746322,0.052113224,0.120563135,-0.008458647,-0.039571974,0.00034822096,0.13043544,-0.0059246975,-0.05862351,0.0020539206,-0.0205904,-0.033106677,-0.042667888,-0.0468837,0.038259808,0.005854052,-0.015250161,0.047656097,0.029486677,-0.110168785,-0.017082017,0.005430543,-0.022111652,-0.035167202,-0.01602096,-0.05064758,-0.03690825,0.02536062,-0.068484865,-0.033662047,-0.0318438,-0.024997877,-0.020896466,-0.0695059,-0.00015837218,0.04497762,-0.014487551,0.018004572,0.049250036,-0.0018638992,0.0070575024,0.00044391587,0.004798672,0.020138482,-0.07220646,-0.1018022,-0.03655401,0.059843965,-0.082814075,-0.08962399,-0.005546011,0.05264277,0.03157349,0.16669552,-0.012413869 +1.14.11.38,"Requires Fe2+ and ascorbate. Found in the fungus Aspergillus fumigatus. Both atoms of a dioxygen molecule are incorporated into verruculogen [1,2]. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A. ",384,1.0,0.0021080803,-0.0043418636,-0.11416824,0.082413934,0.056871995,0.02030467,-0.02967787,-0.00057933136,0.038208243,-0.044633783,0.038438827,-0.058537528,-0.046097696,0.015970727,-0.08025504,0.022585018,-0.024504641,0.040211152,0.006475739,-0.0149151385,0.049112804,0.06474154,0.098989405,-0.03415924,0.013877056,0.023822745,-0.0265954,0.023325445,0.016297936,-0.11545887,0.02743667,0.052613277,0.004078522,-0.04177657,0.016078925,0.06308893,-0.08458508,0.054471795,0.11656044,0.015522093,-0.10007931,-0.06412998,-0.01989282,0.014593685,-0.086097345,-0.06718304,0.018557543,-0.004974469,0.053440124,0.010751778,-0.036117576,0.052230034,0.00018259896,0.066998884,0.07030435,0.021828352,0.02178884,-0.019809311,-0.090518266,0.023663303,0.036724273,0.031304274,-0.036411196,-0.030257925,-0.09445671,-0.0044868966,0.0023193865,-0.024104591,-0.0051267524,-0.037811685,0.026050951,-0.03562549,0.03042971,0.007965471,0.011781833,0.11415588,0.040779095,-0.03694664,0.013165896,-0.03812965,0.05116587,0.024097037,0.06576041,0.04400411,0.003471038,-0.007944046,-0.029456737,-0.018398419,-0.044813216,0.05365817,0.04363678,0.070912585,-0.019795531,-0.04018782,0.052318543,0.041227445,0.11558998,0.07743107,0.051912643,-0.009787407,-0.008250632,0.022345683,-0.05853118,-0.02381814,0.00409146,-0.04287032,-0.08056501,0.008028563,0.041723236,-0.043273438,0.0454785,-0.016074937,0.08073787,-0.028308991,0.028033914,0.013865453,0.05043882,-0.03628515,-0.010544484,-0.026615918,0.016612278,0.03735492,-0.017362239,0.06599042,-0.036877915,-0.008549791,-0.054926768,4.728022e-33,0.09376735,0.092684984,-0.071483,0.048556212,0.0050471276,-0.019184697,-0.06937216,-0.023074219,-0.017684394,-0.02766425,-0.13912304,-0.047737885,-0.03490167,0.031514652,-0.021173267,-0.06848253,-0.04492561,-0.071802124,0.051435158,-0.06282943,0.027723074,0.05431214,-0.059683755,-0.024333933,-0.07087274,0.092675015,0.024296602,0.015766641,0.028084585,-0.02602344,0.055982534,-0.050451923,-0.07944007,-0.004413976,0.048926897,0.012480594,-0.05112147,0.027976498,-0.08356745,-0.021943418,0.047158215,0.13065341,-0.04669209,-0.062101826,0.09423151,-0.031805262,-0.046011068,0.107021354,0.083354056,0.093344845,0.037026387,0.048357368,0.092482276,0.015710931,-0.049327422,-0.017894562,-0.011175183,-0.017281204,0.026124073,0.099549875,-0.04124263,0.016470136,-0.017863631,0.047404602,0.035098158,-0.013540226,-0.04720985,-0.028284311,0.00081254647,0.062750846,-0.042916454,0.023679001,-0.0015066983,-0.0038635482,0.0012501827,-0.028958555,-0.079122625,-0.017755156,-0.007554029,-0.030056193,-0.006190134,-0.030423708,-0.0152019765,-0.02583177,-0.034694616,-0.016600024,-0.053959534,-0.056146048,0.017558658,0.065773964,-0.05311283,-0.035347905,-0.055493772,-0.0005778874,0.07834887,-6.630327e-33,0.029094528,-0.078702055,0.05307846,0.0036527007,-0.04912977,0.094185725,-0.012784212,-0.016450584,0.0026625255,0.030696455,0.05260512,0.005399485,0.08817349,-0.032934938,-0.02411459,-0.038076114,-0.0043303464,0.127186,0.013354317,0.06413897,-0.05342851,0.099562265,-0.011504722,0.050713513,0.093336724,0.035250843,0.007734141,-0.0110500585,-0.06925125,0.021585697,0.033014946,0.05145198,-0.064191334,-0.06876678,-0.044412047,0.017659783,-0.03199123,-0.020972896,-0.04103074,0.036566928,-0.01491445,0.054291315,-0.00031102373,0.15111469,0.02826746,0.011001805,-0.12331222,0.061111312,0.07073068,-0.02944908,-0.0112636,-0.02076238,-0.053180434,-0.07685475,0.036842357,-0.027205193,0.04169724,-0.020263325,0.07196805,0.0323178,-0.0585291,-0.038476184,0.004403565,-0.06872248,0.039054222,0.015156112,-0.018888121,0.06358888,0.09383989,-0.013810421,0.086527996,0.040253427,0.03178071,0.012229989,0.0030729023,0.00028414122,-0.011288524,0.010680308,-0.007249998,0.053059936,0.0020535598,0.017328396,0.036987867,-0.05564121,-0.027739782,-0.09877305,0.029581541,0.049679972,-0.1041088,-0.029496487,-0.021376114,0.012568188,-0.054312136,0.017509168,0.05479264,-3.769431e-08,0.010645339,-0.010825478,0.013708282,-0.06865973,-0.00603081,0.017855043,0.061439674,0.01016777,-0.045025915,-0.09071782,-0.019942317,0.12630911,0.0053126914,0.058039036,0.037056696,-0.02672489,-0.03202847,0.05187405,-0.0426515,-0.023749938,-0.050151166,-0.0075382073,-0.07730422,0.023593577,-0.017616805,-0.042102933,0.0193817,-0.06047329,0.064835,-0.0020334297,0.021424625,0.018962607,-0.026108507,-0.09534984,-0.06271847,-0.018151658,-0.041601665,-0.042887688,-0.06416033,-0.04577399,-0.013912695,-0.014621759,-0.046447847,-0.028576115,-0.105410606,-0.043254748,-0.04486787,0.066085555,-0.035747413,-0.01750846,0.051617693,-0.04814985,0.01734676,-0.059708696,-0.13394828,-0.0018968263,0.015319003,0.020172467,0.0069216704,-0.11733114,-0.049624026,-0.036135715,0.15056978,-0.047045223 +1.14.11.39,"Requires Fe2+. The enzyme is only able to hydroxylate free L-asparagine. It is not active toward D-asparagine. The beta-hydroxylated asparagine produced is incorporated at position 9 of the calcium-dependent antibiotic (CDA), an 11-residue non-ribosomally synthesized acidic lipopeptide lactone.",384,1.0,-0.031818464,-0.10378215,-0.047858927,0.044211444,0.02788741,0.020680271,-0.09872487,0.07797694,0.004083921,-0.045303665,0.0030367433,-0.0067536724,-0.02496104,0.034323137,-0.03566304,-0.04721654,0.03289821,-0.013749235,-0.029488247,-0.0034281716,0.02732745,0.037968066,0.05951584,-0.018005224,0.03446402,-0.045553572,0.033052854,-0.08414483,0.0019635467,-0.117661186,0.043254476,-0.058418237,0.05642793,-0.01142423,0.05359829,0.045315895,0.020639796,-0.008985629,0.07157896,-0.0070989025,-0.022767054,-0.024078604,-0.036364514,0.032138318,-0.05130514,-0.08264374,0.0067243846,0.026620336,0.04409021,0.05419346,-0.10106568,-0.0028823246,-0.08978079,0.05646779,-0.076754145,0.08127772,-0.048552573,-0.02350454,-0.013693771,-0.0014128851,-0.015950164,0.037245486,0.037706345,0.009205589,-0.016332839,-0.042059872,0.0011739377,-0.039720196,0.059100043,0.035664994,0.012256299,-0.07633227,0.06374576,0.05867262,0.04633213,-0.027086593,0.06652277,-0.040685408,0.050161548,-0.044678822,0.07777874,-0.067670226,0.0147102345,0.14813471,0.037350792,-0.0009802425,0.016943274,0.02332755,0.047040086,0.054855105,0.008097596,0.03925213,-0.03485947,-0.026619822,0.010057919,-0.030686406,0.07833116,-0.012504353,-0.0641361,-0.008482439,-0.06864949,0.046668533,-0.052345492,-0.035663024,0.028008206,-0.037253954,-0.023699269,-0.01026632,0.005598255,-0.024926556,0.060473334,-0.009538964,0.001039111,-0.0386798,-0.08185599,-0.015707,0.04537108,-0.089598455,-0.060529042,-0.096661545,0.040405847,-0.024123821,-0.03589566,0.10557788,0.008311983,0.04554452,-0.051208913,2.0050611e-33,0.052549504,0.044069096,0.02664934,-0.09126667,-0.08658639,0.014580355,-0.04444391,-0.0557772,-0.0072882455,-0.076804295,-0.04991871,-0.16147889,0.015737737,0.06792873,0.03249922,-0.049546707,-0.0015471416,0.034905694,0.046871893,-0.019825373,0.03996291,0.04125666,-0.022102075,0.045686964,0.024305522,-0.009200689,0.015342151,0.07901072,0.10133127,0.00782727,-0.017926905,-0.100143656,-0.07562329,0.05110007,0.06426899,0.050197143,-0.07291544,-0.056184344,0.038302317,0.06201576,-0.028945638,0.060216375,0.030010013,-0.06543217,-0.00964844,-0.07646734,-0.045641847,0.058647264,0.018445129,0.052427262,0.032939143,-0.014402329,0.050226312,-0.012202081,-0.0223745,-0.002725886,-0.07820056,0.04261855,0.07343457,0.050683085,0.023322096,-0.09564018,-0.018764542,0.026308572,0.04337412,-0.012371722,-0.031682543,0.035577502,0.019546434,-0.0041333474,-0.08062042,-0.016503159,0.053733826,0.019848898,0.035958927,-0.0070887557,-0.07166665,0.022672564,0.115131095,-0.046980657,0.00655917,-0.03196402,-0.019591417,0.0591436,0.036470022,0.04487247,-0.010209777,0.024529973,0.042158503,-0.015290272,-0.0016332148,-0.074748315,-0.07750883,0.04303853,0.031543817,-3.1843664e-33,-0.01247724,-0.02334543,0.04232735,0.037047494,-0.05810328,0.039676256,0.04874719,-0.035141326,0.048964016,0.015525206,0.011819672,0.035681173,-0.03613341,-0.08658224,-0.02674034,0.075489745,-0.03719646,0.05763648,0.0027232412,0.005710166,0.016710192,0.031518728,0.0043043126,0.11727832,0.049777184,0.010949217,-0.042738523,0.013721241,0.03255125,0.10158091,0.06453028,0.0722048,-0.035277564,-0.10938442,-0.089888155,0.069355406,-0.0827524,0.015185208,-0.021425907,0.0545652,-0.037851702,-0.0003957253,0.02497359,0.056817316,0.008259546,0.053038172,0.04669579,0.057129413,0.019022522,0.012115167,0.0038209683,-0.041403897,0.02335209,0.010013368,-0.028555192,0.010597769,0.05171869,0.08492057,0.0065183872,-0.03831106,0.028666548,-0.013265075,0.06383623,-0.14994225,0.021562364,0.0035154335,-0.04672118,0.069348246,-0.006360746,-0.043286093,0.026109418,0.0019697407,0.055209737,0.015362904,0.032650746,-0.06489723,-0.044889424,-0.021397866,0.006098018,0.010736766,-0.026357597,0.049033962,0.008744705,-0.00023571597,-0.0083736405,-0.0018355423,0.044080574,0.050939184,-0.023490122,0.06470785,-0.03759703,-0.045230754,-0.023742821,0.09871479,0.10967205,-3.7627153e-08,0.064045876,0.008648352,0.011416551,-0.09641501,0.0039843535,0.0023696688,-0.009632484,-0.024629341,0.01460849,-0.042966306,-0.06108746,0.086994216,-0.014686707,0.029744124,-0.066627644,0.008411663,-0.03228181,0.07764677,-0.06821322,0.0013592662,-0.08579022,0.011924531,-0.12409179,0.015652891,0.031975456,-0.0038068832,0.0017764857,0.005885144,-0.0064815376,-0.02843648,0.037813317,0.04661765,-0.027334498,-0.114464425,-0.076654315,0.0068044127,-0.034969248,-0.04535117,0.059510205,0.036755312,-0.00986135,0.01710036,0.025962949,0.021388197,-0.039740294,0.016057082,-0.032048408,0.009409357,-0.06370574,0.052777607,0.046210956,-0.08486597,-0.046986893,-0.11167562,-0.05261094,0.05765005,-0.06913167,-0.06824842,0.016289305,-0.10081862,-0.021457924,-0.0660953,0.18208563,-0.06570433 +1.14.11.40,"Fe2+-dependent enzyme. The enzyme is involved in biosynthesis of the nonproteinogenic amino acid beta-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439. ",384,1.0,0.027348543,-0.0008905954,-0.15838516,0.04773349,0.06849841,0.034936856,-0.027273513,0.044795487,0.007832733,-0.06636602,-0.003275307,0.020809706,0.058201917,0.03414111,-0.065281354,-0.06634892,-0.08512185,-0.026908733,0.04270094,-0.035563212,0.067436285,0.050537836,0.0268707,-0.02463581,-0.028182743,-0.00721363,0.0176704,-0.058927167,-0.07685123,-0.05477904,0.020499457,-0.058974594,0.05047652,-0.07217851,0.07308614,0.05529345,0.0027823504,-0.015664816,0.097587936,0.012432375,-0.075723626,-0.035916157,-0.052486278,0.0023564252,-0.058949694,-0.034876764,0.06159472,0.021133764,0.0065322127,0.082973264,-0.061738066,-0.04244988,-0.034498394,0.032118145,0.08043304,0.04757587,-0.017453635,-0.030378615,-0.011244829,-0.026496397,0.023339927,-0.03424405,0.07114743,0.0030310503,-0.04062577,-0.036120173,0.04449353,-0.09809967,0.0488643,-0.047287494,-0.054305945,-0.050367024,-0.012575722,-0.030663794,0.024320588,-0.020939928,0.025487268,-0.054368224,0.07722017,-0.03891784,0.019427447,-0.052706875,0.01901658,0.083936796,0.0020495073,0.038583677,-0.01176355,-0.030706504,0.015686026,0.04244076,0.031702768,-0.016380467,-0.012794519,-0.042137295,0.00039960834,-0.033470325,-0.035613928,-0.014114238,-0.013468523,0.013325819,-0.026642727,0.046422,0.015002651,0.005717361,0.017489562,-0.01834684,-0.0015388179,0.04434753,-0.03203181,-0.013436065,0.034364957,0.084827185,0.024986291,-0.024333062,-0.028616747,0.08205216,0.11246377,-0.048344094,-0.07667773,-0.047863163,0.09733386,0.038938668,0.0059536025,0.06349366,-0.038327668,0.0035965082,-0.10891132,4.3111703e-33,0.01150609,0.054421358,0.048365153,-0.05068584,0.05873241,0.013548368,-0.06629665,-0.02417507,0.020016896,-0.014971717,-0.09013817,-0.08165236,0.0008754719,0.0436203,-0.009423279,-0.035880152,-0.049848087,0.03791478,0.045504298,0.0055688354,-0.01544553,0.101278864,0.028375046,-0.025183326,0.0759317,0.1017148,-0.05870334,0.052004766,0.08976322,-0.0022524195,0.0386835,-0.07921718,-0.07834828,-0.04462302,0.09851533,-0.051546603,-0.061980013,-0.048613343,0.036158763,0.066518754,-0.0138763925,0.019167794,0.016535737,-0.06811271,0.030934794,-0.04925099,-0.015881363,0.1154556,0.004795468,0.07375943,0.0412387,-0.04883626,0.0486626,-0.034981377,-0.041935448,0.016460266,-0.030883376,0.010613441,0.04522782,0.099100515,0.03180319,0.032046497,0.05855204,-0.0038649032,0.035383534,-0.034716,-0.032971025,0.036716357,0.038032226,0.04602885,-0.057856813,0.024349682,0.07138093,0.05048069,0.02842244,-0.06733751,-0.11045954,-0.033097997,0.09103264,0.006981611,0.0077460497,0.005534056,0.0293119,-0.056735408,-0.034597594,0.045822103,-0.09655372,-0.104767546,-0.0040770895,0.038729813,-0.03206348,0.0026604533,-0.086182155,-0.010803878,0.033215377,-6.688968e-33,0.05458128,-0.06958654,0.05901002,-0.057469435,-0.07190349,0.026994526,-0.025547694,-0.048552018,-0.011004757,0.005752035,0.016891558,-0.030826736,-0.0040737493,-0.1284311,0.011076047,-0.0023633377,-0.0370231,0.08496532,-0.015222161,0.021109581,0.0028974065,0.05459408,0.02003742,-0.025576137,0.052566145,-0.0029858747,-0.039981645,0.06394847,0.07602794,0.09046053,-0.020928109,-0.024003545,-0.04631628,-0.10399765,0.0013992221,0.024663864,-0.08302618,0.040098477,0.07163651,-0.037963368,0.0095582055,0.010863513,0.05888508,0.043436486,0.022129128,0.065415755,-0.051901568,0.07666566,0.004738189,-0.011923464,-0.03084437,-0.039960966,-0.04501721,0.015639277,0.031717848,-0.018638847,-0.007140736,0.044999003,0.013000714,0.018167015,-0.03302849,-0.050476663,0.03936274,-0.010223786,0.07842832,0.030341817,-0.052562565,0.046820566,0.1325443,0.021449275,0.07485952,-0.029107278,0.00758594,-0.0003140872,-0.024696408,0.0202614,-0.104052395,-0.037500698,0.010984615,0.011002525,-0.0025799433,0.03501556,0.0035096982,0.00043154808,-0.039054148,-0.081167035,0.024752913,0.08615715,-0.009172571,0.020167746,-0.02495136,0.011390526,-0.060312122,0.026538111,-0.0037283462,-3.703237e-08,-0.007669835,-0.061498243,0.07037634,-0.0579945,0.016722811,-0.033142883,-0.04037501,-0.05671881,-0.016811859,-0.04398034,-0.030739803,0.07630102,0.058331147,-0.06240783,-0.05455815,0.043051794,-0.07562665,0.06416217,-0.019597933,-0.017644046,-0.115042344,0.012778939,-0.13864003,0.05516441,0.016801033,-0.026225146,0.010118019,-0.00035938257,0.005918284,-0.00072169356,0.059567206,0.0019037966,-0.05317978,-0.07600258,-0.09207158,-0.04958854,-0.09263587,-0.045582946,0.03473263,-0.035164513,0.002142534,0.032575898,0.015742198,0.013569955,-0.062329784,0.034852903,-0.049524702,0.012243258,-0.073517345,0.016468994,0.0466777,0.0010546887,0.004070394,-0.039656892,-0.0789637,0.073402464,0.029786795,-0.085121654,0.013540839,-0.03699644,-0.04296544,-0.0038298767,0.22492787,-0.04323902 +1.14.11.41,"Fe2+-dependent enzyme. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It differs from EC 1.14.20.7, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming), because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine.",384,0.99999994,-0.042262133,-0.03735147,-0.10141975,0.056290325,0.10380667,-0.047495313,-0.03977375,0.046371974,0.06493351,-0.082044944,0.017849166,0.009711394,0.031616334,0.052782647,-0.0745822,-0.07368459,-0.06974351,-0.055371664,0.07824379,-0.010218396,0.077513196,0.029726714,-0.018013515,-0.049338195,0.011253229,0.027188834,0.005863502,0.016495138,-0.06824446,-0.08184712,0.023747284,-0.02706793,0.052749198,-0.0751552,0.03156264,0.04861906,-0.047820024,-0.013537355,0.073556006,0.029376077,-0.10736777,-0.013330543,-0.010816675,0.012032671,-0.018020581,-0.044386037,0.048820883,-0.029064449,-0.021028167,0.049174726,-0.061360277,-0.037909865,-0.03131775,0.045175973,0.083328545,-0.0077613145,-0.06443999,-0.06363339,-0.074226886,-0.0011243491,0.05009848,0.0020429404,-0.008050561,-0.003009804,-0.092458844,-0.03694435,0.051609732,-0.070827566,0.017802397,-0.05556785,-0.08336362,-0.0451112,0.013798612,-0.006389414,-0.025778798,0.025411412,0.024518434,-0.022026641,0.055043943,-0.037233587,0.058061164,-0.0002762181,-0.01196775,0.085721925,0.034160517,-0.0022456916,0.07039202,-0.013907255,-0.0051244865,0.094694,0.0671631,0.04865343,-0.0058655175,0.00032329257,-0.02966066,-0.024020579,-0.03443506,0.04668996,-0.030111788,0.006311962,-0.04005212,0.05993228,-0.0037420106,-0.023434272,0.037878502,-0.007622088,0.008563396,0.038484074,-0.035534278,0.007419731,0.015096673,0.03176684,0.015864978,-0.000887685,-0.0105480775,0.1375542,0.08054245,-0.043473482,-0.03799932,0.01497376,0.089880586,0.025894972,0.040469453,0.07726281,-0.033848185,0.06974576,-0.09269222,1.8496756e-33,0.00034902754,0.035029765,-0.007162896,0.013429366,0.026474344,0.038443055,-0.07493812,0.004075669,-0.04583267,-0.0044625564,-0.08350982,-0.07386699,0.06581715,0.03728628,-0.0027332564,-0.07103391,-0.050766192,-0.012395191,0.03380931,-0.000542052,0.047790132,0.078205675,-0.014706207,0.009122833,0.042172812,0.038586944,-0.03041723,0.04405278,0.022352276,-0.02410188,0.023648022,-0.06639561,-0.035467327,-0.043211956,0.11436256,-0.065080665,-0.0037857308,-0.05593175,0.004410424,0.0773641,-0.0013197032,0.04728533,0.050575677,-0.052804664,0.08114317,-0.076110065,-0.08221242,0.16429032,0.028505718,0.06883393,0.016655393,0.0097329635,0.00051110896,-0.055371653,-0.059449717,0.05067119,-0.016550107,0.043776855,0.030257694,0.058140893,0.035780136,0.014003765,0.010327927,-0.008604431,0.02360024,0.047939576,-0.08148397,-0.039971694,0.014443052,0.1358732,-0.0625163,0.02721068,0.0677096,0.017877854,0.076080665,-0.059112735,-0.13100268,-0.01697407,0.08639992,0.030543873,-0.06956196,0.021683415,0.023701923,-0.060242232,-0.039344534,-0.027213737,-0.05185763,-0.014918241,0.036050238,0.03046899,0.02521496,0.0111341085,-0.07288741,-0.015926728,0.07457932,-3.309571e-33,0.037129436,-0.06312441,0.05344692,-0.063114956,-0.050698575,0.09753312,-0.019491116,-0.0780273,0.0094715655,0.007884652,0.04004774,0.005055871,-0.0056119384,-0.09094417,0.033410363,-0.033361316,-0.08357729,0.013666274,0.014654926,0.018867716,-0.021213435,0.071924284,0.031189155,-0.007001581,0.07190878,-0.006629015,-0.011832323,0.0658488,0.061317883,0.065520905,-0.018744545,-0.04755185,-0.029814722,-0.05121266,-0.039027102,0.05506184,-0.050799757,-0.024102727,0.040063906,0.016371436,-0.026137134,-0.02357767,0.024030926,0.048997454,-0.014458179,0.041825335,-0.05678163,0.055830266,0.026438836,-0.09452419,-0.0063928915,-0.020035192,-0.027269358,0.036361966,0.0013737824,-0.03137346,-0.0073898304,0.026245855,0.033507507,0.03654787,0.028515873,-0.05066301,0.04569644,-0.02669973,0.059346028,-9.1099704e-05,-0.057260953,0.082182355,0.090367205,-0.010497359,0.07439539,-0.01862924,0.010168683,-0.023879508,-0.00014057352,-0.02638067,-0.040804066,-0.042537585,-0.008149236,-0.03536879,0.027402662,0.01775768,-0.028161623,0.0024190487,-0.11576946,-0.028824974,0.020042988,0.06788379,0.0069129854,0.027571144,-0.047857873,0.005192401,-0.06105711,0.018030185,0.0015631038,-4.2860453e-08,-0.018733365,-0.05779617,0.04135039,-0.013983372,0.0115770325,-0.014018058,-0.02002345,-0.03085701,0.024278829,0.005960689,-0.010591578,0.11657051,0.06027053,-0.04007941,0.0077277063,0.07524419,-0.033322453,0.07631721,0.005759957,0.06054611,-0.07399824,0.006532823,-0.18306312,0.0035740878,0.0034977135,-0.052839242,-0.025046196,0.014130882,-0.030059323,-0.025374679,0.03175499,0.008297647,-0.0099812,-0.051271092,-0.11881727,-0.008848572,-0.10470411,-0.072697,-0.017747909,0.0012348578,0.046708673,-0.02907129,-0.053375818,0.002604285,-0.035757225,0.02514545,-0.008679153,-0.06956701,-0.06100734,0.0026627139,0.061404817,0.0030783995,0.033051115,-0.0028428973,-0.03375735,0.068816744,0.011886801,-0.09251315,0.061329592,-0.037953038,-0.062540546,-0.012523658,0.24182676,0.0009286042 +1.14.13.177,A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of the indole alkaloid verruculogen.,384,1.0,-0.009217111,-0.02009268,-0.012188741,-0.010105767,-0.03203512,0.108086325,-0.051310856,0.089606754,0.053282924,0.02015933,-0.029277528,-0.040786766,-0.0097884815,0.026803022,-0.024924235,0.0037688937,-0.034810122,0.04551177,-0.030571623,-0.1431313,-0.01658442,0.10070107,0.09166912,-0.023869868,0.041691348,0.0020083392,0.013099108,0.056761466,-0.03552442,-0.058497828,0.027021717,-0.025023613,0.038608585,-0.032993842,0.0021809933,0.062275134,-0.11068974,0.0029783025,0.07986692,-0.02593682,0.060725033,-0.08300096,-0.11922126,0.039989293,-0.027827147,0.011154968,-0.009491742,0.033792526,0.020605188,0.019587308,0.018902447,-0.012195393,-0.039226796,0.08352957,-0.026579438,-0.056591645,0.07033996,0.097735964,0.010154581,0.014727292,0.0027318296,0.074282736,0.0013520784,0.016906973,-0.055512954,-0.05501072,-0.013653914,0.00041205224,-0.0031861067,-0.0072575775,0.013417867,-0.08209793,-0.038187817,0.05803334,-0.052219465,0.058844835,-0.04672459,-0.028824043,-0.08702079,-0.027904943,0.10683374,0.08812613,0.043478366,0.10367428,-0.063722715,-0.007010016,-0.0032042095,0.015600897,-0.043077894,-0.054863244,0.051201254,0.00070919195,-0.023730317,-0.035277523,-0.025086854,0.07782574,0.044350374,0.0015223045,0.006591068,-0.03620532,0.04284071,0.0132790385,-0.051781364,-0.034622625,-0.045904722,-0.01268043,-0.023782719,-0.036206312,-0.0023830808,-0.056457993,0.0136567475,-0.018517118,0.06199164,-0.003269222,-0.034523223,0.06641444,-0.050262354,-0.018917073,0.0051095057,-0.058029503,-0.0694085,-0.029027363,0.021721398,0.060396064,-0.0383443,-0.05971051,-0.06391085,3.0219274e-35,0.09757952,0.020223757,-0.013958453,0.0051825074,0.031228526,-0.06717054,-0.07465497,0.04606343,-0.009109417,0.025594745,-0.05361416,-0.10588152,0.03538088,-0.033724215,0.00011810917,0.017061207,-0.14470217,0.008522984,0.0038727012,-0.037695527,-0.09449417,0.014200661,-0.05908478,0.03255421,-0.08954914,0.096259184,0.054780472,-0.0046663745,0.043770667,-0.025114667,-0.008620456,0.012714381,-0.025743263,-0.03383826,-0.06381428,-0.015632054,-0.014006222,0.038862262,-0.05745077,0.05332668,0.07475636,0.08670613,0.026230764,-0.016202593,0.08478049,-0.010566728,-0.11496755,0.08291059,0.019354826,0.11210806,0.06636317,-0.024080018,0.14474142,0.034488145,-0.039188355,0.026062256,0.0026917553,0.005099959,-0.011660872,0.05218754,0.032448474,-0.015130534,0.029868685,-0.0033287974,0.00029409723,0.029329028,-0.051875737,-0.096177705,0.010002757,0.07941465,-0.039865755,0.0221134,0.046599157,-0.01611374,-0.016313277,-0.006945789,-0.0055169435,0.055782665,0.016669886,0.020213744,-0.0066814795,-0.01915791,0.025071383,0.012735075,0.065653645,-0.06303691,0.004308714,-0.060658477,-0.006379513,0.04341685,0.0684895,-0.05721819,-0.089377694,0.08207736,-0.013306038,-6.5296085e-34,0.097951375,-0.08077219,0.008102504,-0.01966727,-0.029538728,0.032922883,-0.045656413,0.04494069,-0.0048459447,0.079420485,0.14157826,-0.006047029,0.06603825,0.042966437,0.02209044,-0.07643912,-0.013927174,0.071878925,-0.06609915,0.11638672,-0.074360244,-0.004268733,0.0018918554,-0.0039975583,0.070657425,0.052357707,0.0070577273,-0.0027499855,-0.07308632,0.022967478,0.06152102,-0.00043710132,-0.14886779,-0.009525501,0.014068824,0.017488029,0.011577541,-0.004663352,-0.023921,0.021031735,-0.02324832,0.0821059,0.031740148,0.012409344,0.04274163,0.04096014,-0.055898566,0.0091902325,0.014614592,-0.08663757,0.044134643,-0.0004718156,0.021407073,-0.0022393912,-0.02367425,0.0015052026,-0.010914127,0.028353395,-0.013058476,-0.07225568,-0.044841904,0.01054299,0.049892623,-0.0065256283,-0.045972165,0.04091852,-0.04818741,0.032389943,0.060244545,-0.042605914,0.012256012,-0.012340804,0.047584165,0.042640712,-0.008464879,-0.061232597,0.01285028,-0.045016263,0.04353602,0.02274763,0.0054276926,0.077654876,-0.056252975,-0.09450304,0.02465107,0.0013098025,-0.046994943,0.16519617,0.04057922,-0.005781751,0.030550672,0.04735526,-0.055156764,0.08081719,0.09629227,-2.7135727e-08,0.0010274022,-0.06329959,-0.04032095,0.044817366,0.024204526,0.022034835,0.014912614,0.015219046,0.0046284418,-0.04071008,0.018271208,0.014283165,-0.084179126,0.03113189,0.022753345,-0.017851422,-0.0047962903,0.046903633,0.012117385,-0.024239955,-0.046643488,0.020295843,0.013918866,0.01650855,0.039554015,-0.06601936,0.022347918,-0.08758838,0.040277597,-0.056753244,0.037263714,0.045252416,-0.05763701,-0.012624265,0.047447853,0.00089240435,-0.016056249,0.0017328132,-0.014408842,-0.03862787,0.0023106474,-0.06087877,-0.08673762,-0.046416607,-0.02697103,-0.020501187,0.025345087,0.0730778,-0.036908876,-0.047628038,-0.028507238,-0.028613636,0.019069018,-0.10408472,-0.12955508,-0.049125496,-0.013444604,-0.015843913,-0.026863283,-0.10179637,0.0026121228,-0.035820905,0.15721326,-0.02176717 +1.14.13.178,"A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, methylxanthine N3-demethylase, and has a 5-fold higher activity with NADH than with NADPH [2]. Also demethylate 1-methylxantine with lower efficiency. Forms part of the degradation pathway of methylxanthines.",384,1.0,-0.035385262,-0.013346736,-0.11266122,0.03358274,0.06104194,0.056556948,-0.063486174,0.046563633,0.02735397,-0.08090917,-0.015836569,0.025185814,-0.036594965,0.05701672,-0.047868375,0.052257817,-0.060914524,-0.00786532,-0.0027884834,-0.018412339,0.019864427,0.07099132,0.02879089,-0.011463854,0.0041370727,0.01001346,0.054637894,0.006730871,-0.0062358337,-0.010771452,-0.057754364,-0.03449484,0.050448325,-0.06448521,0.05940505,0.04971932,0.019016368,-0.021675764,-0.0041746832,0.0066246893,0.01700905,0.009242435,-0.071393095,-0.04521378,-0.06915599,-0.026710503,0.06653576,-0.00046820482,-0.0031361892,0.020637369,-0.05994944,-0.033142123,0.041078884,0.058846895,0.06307643,0.017596602,0.04628544,-0.044164997,-0.0545041,0.006443398,0.026792886,-0.040152382,-0.022191832,-0.009637977,0.027882772,0.018396858,0.08122903,-0.047323253,-0.07129443,-0.07094363,-0.08553291,-0.01788652,-0.0421878,-0.026541078,-0.032340012,0.0061597307,0.042504985,-0.04485006,0.07320893,-0.03022173,0.0037770935,0.00984077,-0.032928053,0.075771265,0.022303771,-0.02307961,-0.003002363,-0.014301756,0.013871666,0.021291427,-0.07358092,0.01057282,-0.059798915,-0.0696998,-0.064411104,0.03701404,0.022617912,0.10042014,0.046054043,-0.007487186,0.007938433,0.08644446,-0.031053687,-0.06331403,-0.09285923,-0.008301631,-6.163539e-05,0.14788373,0.052344292,0.044713773,-0.011049327,0.0027143548,0.023927543,-0.023143869,-0.046662245,0.052785765,0.041505672,-0.0024729986,-0.14054719,-0.014958417,0.0013271853,-0.024906654,0.022259364,0.056080587,0.06385789,-0.046022303,-0.18435007,2.1721951e-33,0.094679505,0.06601946,0.018263245,-0.018007394,0.0045651253,0.017603176,-0.09165457,0.041920546,0.028210336,-0.016131174,-0.03778494,-0.08492177,0.024710035,-0.034954693,-0.0025042703,-0.07595155,-0.013230158,-0.040839493,0.008916059,-0.02834561,0.0875085,0.09794031,-0.008072218,-0.016821587,0.022411834,0.014184967,0.03976499,0.015291793,-0.029163936,-0.021845877,0.045726083,-0.107375786,-0.13121714,-0.047433425,0.09542466,-0.050654523,-0.06028352,-0.005403199,-0.034653198,0.051726833,0.02626767,0.09071518,-0.01252048,-0.080447726,0.07317139,-0.09120724,-0.037810482,0.10638167,0.027066741,0.11528079,-0.010179714,-0.038317923,0.10811587,-0.021004992,-0.062529825,-0.014719056,-0.031001024,0.018281395,0.02568729,0.051060632,0.06587353,0.016388543,-0.046836916,0.048425104,0.0007398283,0.0017246614,-0.05659192,-0.00046536562,0.083895124,0.021408962,-0.012603106,0.073603824,0.013517732,0.012137062,-0.024143064,-0.07959687,-0.07698875,0.024380306,0.09494184,-0.021282801,0.00942958,-0.056666497,-0.017895455,-0.043041226,-0.049888875,0.01135201,-0.009897648,-0.005107391,-0.053458437,-0.01860147,0.0759349,-0.09920204,-0.009375994,-0.039921068,0.046179954,-2.5090565e-33,0.02904036,-0.033161443,0.09067456,-0.1154343,0.011766245,0.044721413,-0.0071488516,0.070511706,-0.08079932,-0.037226252,0.04436073,0.058774397,0.044042364,-0.061058093,0.03259388,0.01865691,0.006655338,0.014768958,0.03294204,-0.026856756,-0.035715073,0.07530021,-0.03859115,0.015012478,0.035978295,0.046171058,-0.0348352,0.089886904,0.09919732,0.045874353,0.009350418,0.07047484,-0.05423224,-0.054250576,0.0412571,0.01827921,-0.011494094,0.03600763,0.0028088256,0.029744225,0.0457102,-0.009333221,0.03184684,0.08735289,0.005342058,0.10503268,-0.17459881,-0.030982023,0.046200152,-0.048713617,0.013961045,-0.005051181,-0.051381122,0.017711699,0.09268938,-0.034352053,-0.0030393545,0.053659752,-0.020908875,-0.032636244,-0.01992103,-0.04359303,0.027558384,0.06297749,-0.0017606979,0.03279169,-8.270117e-05,0.051887553,0.005372225,0.023513727,0.03661005,0.031114383,-0.01967841,-0.029738959,-0.07807235,-0.045384236,-0.02035093,0.05048255,-0.02429323,0.054332335,0.04644956,-0.08150996,-0.06834908,-0.08946967,0.021361204,-0.051663157,0.0522362,0.0524952,-0.06287911,-0.026225565,-0.018788936,0.027622947,-0.028259596,0.020053495,-0.033856492,-3.8388464e-08,0.024793321,-0.09854519,0.066105366,-0.025400981,0.013322252,0.01519913,0.041156508,0.020743994,0.019981304,0.02132154,0.014476559,0.04124027,0.01901728,-0.05587504,0.032428313,-0.04385639,-0.07450119,0.051518336,-0.016012056,0.008687016,-0.050522268,0.0015874546,-0.09585882,0.0525994,0.017287968,-0.06642015,0.031212516,-0.03419485,0.076983385,-0.070991084,0.00025772757,0.055230565,0.07972964,-0.019011466,-0.13187024,-0.020312749,0.013915786,0.03632508,-0.07436804,0.035118558,0.018389545,-0.03633056,-0.07434865,0.015485357,0.06525107,0.019436916,0.034112453,0.008141924,-0.038923807,-0.06332627,0.023472222,0.026044244,0.00402236,-0.034817874,-0.102366336,0.071376994,-0.0040230933,-0.012018118,-0.011589275,0.031829044,0.011895289,-0.029583823,0.1138816,0.021297447 +1.14.13.179,"A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, methylxanthine N1-demethylase, and has higher activity with NADH than with NADPH [1]. Also demethylates caffeine and theophylline with lower efficiency. Forms part of the degradation pathway of methylxanthines.",384,1.0,-0.035270035,-0.011614397,-0.106622525,0.051663626,0.079458736,0.07549443,-0.053950854,0.054504793,0.034586783,-0.08652132,-0.029127322,0.013943771,-0.023163825,0.058980305,-0.047852885,0.038161572,-0.046993613,-0.017601008,-0.002750064,-0.019275585,0.018761544,0.06253896,0.035655327,-0.015351861,0.013529908,0.021684833,0.054791167,-0.014261925,-0.008855725,-0.015047633,-0.049207527,-0.033804156,0.048796006,-0.06245506,0.0504927,0.06338247,0.024362994,-0.028850148,0.00883136,0.009517195,0.014319385,0.011910494,-0.06307856,-0.03866728,-0.06441738,-0.034375705,0.08076053,-0.0037289471,0.00704236,0.017970601,-0.057638384,-0.035393465,0.054414626,0.060234606,0.074094795,0.016751565,0.04422424,-0.049696844,-0.036563367,0.021475088,0.036873333,-0.052718244,-0.02362569,-0.0011379012,0.019534709,0.021734575,0.07074622,-0.03548401,-0.044032376,-0.08320656,-0.088935085,-0.017302418,-0.026328247,-0.03779293,-0.039250236,0.008509906,0.04153975,-0.04610793,0.06488714,-0.031790808,-0.0040045213,0.0014881992,-0.022174591,0.080703795,0.040391896,-0.026200132,0.013830051,-0.009292878,0.0067433985,0.026777118,-0.06769679,0.017463328,-0.044606403,-0.05703939,-0.06552562,0.025415545,0.028809544,0.09908818,0.03928913,-0.0062071015,-0.009162299,0.08936876,-0.040669817,-0.060937498,-0.08511762,-0.013289404,-0.0054499935,0.13974246,0.06788504,0.037468523,-0.005072148,0.010532355,0.0058790795,0.0013710315,-0.033875372,0.055619933,0.049901314,-0.011504669,-0.14619583,-0.018225776,-0.01014157,-0.029859385,0.027777141,0.044519745,0.059142243,-0.05927176,-0.17400752,3.130877e-33,0.08848374,0.07366451,0.010901374,-0.03346827,0.03825078,0.015927771,-0.082178414,0.05626987,0.047843464,-0.022833038,-0.045808274,-0.08081698,0.013887661,-0.039622862,-0.00215417,-0.08657301,-0.021993067,-0.04618524,0.007901658,-0.028542664,0.090399124,0.08448059,-0.007854351,-0.00971008,0.014124462,0.023177037,0.043996368,0.028895514,-0.018152425,-0.021238832,0.022484792,-0.10980526,-0.1268362,-0.029771265,0.073461816,-0.05261536,-0.055092808,0.0035175958,-0.026510524,0.068144,0.018100945,0.09120008,-0.023057103,-0.07674837,0.06905586,-0.0876039,-0.046858374,0.10641019,0.026022347,0.11492242,-0.024219591,-0.046641026,0.11191106,-0.019187016,-0.05793404,-0.027485622,-0.042544052,0.020137697,0.031423878,0.047491267,0.07037229,0.013575399,-0.040042564,0.040956344,0.00012718911,-0.0031428523,-0.06530258,-0.020914836,0.07688948,0.013042179,-0.0052057616,0.06959103,0.010415675,0.0073170285,-0.0077328836,-0.08361085,-0.09772441,0.030159371,0.07864904,-0.022670945,0.027474146,-0.059570346,-0.0120016495,-0.041142315,-0.052353963,0.01355069,-0.005570229,-0.00834193,-0.053077344,-0.018246867,0.061103288,-0.08695772,0.0040772106,-0.04783171,0.02541897,-2.9298001e-33,0.04872336,-0.03805161,0.08926837,-0.1162415,0.0067931972,0.060987115,-0.011392751,0.059915155,-0.07690196,-0.052665524,0.061112296,0.053498745,0.038336743,-0.04922112,0.010300533,0.003361823,0.005561786,0.027193459,0.011347753,-0.030306581,-0.04271528,0.061684366,-0.045393776,0.011124598,0.05316098,0.057137795,-0.03318391,0.08813747,0.0873648,0.0622685,0.0067300396,0.080675624,-0.066465184,-0.04507937,0.056696765,0.02055683,-0.020940073,0.037487496,0.0038828196,0.04354409,0.051126827,-0.0067003807,0.026034398,0.08819689,0.011748895,0.08928531,-0.1997848,-0.039176032,0.034700494,-0.037988476,0.03549737,-0.011208553,-0.07053061,0.01868826,0.06810868,-0.029255843,-0.009560763,0.050983205,-0.018625462,-0.03656896,-0.016980603,-0.046513814,0.017263507,0.057970624,0.00360186,0.019223792,-0.019748472,0.06865554,0.018267188,0.027082536,0.057607178,0.026504364,-0.006377459,-0.0011873831,-0.08481243,-0.020609137,-0.001786358,0.032867905,-0.01778029,0.045828328,0.050587747,-0.056125116,-0.066370435,-0.100956105,0.008812711,-0.048218925,0.06683604,0.044550806,-0.05453948,-0.02232545,-0.026430305,0.00920303,-0.038579546,0.037487973,-0.008620646,-3.8796895e-08,0.019964004,-0.09684923,0.060870986,0.00263258,0.0031422896,0.01827619,0.03971065,-0.00012602398,0.026333783,0.004764661,0.0065448494,0.045628704,0.020366248,-0.036837462,0.012536288,-0.0499227,-0.0747747,0.05977157,-0.00725134,0.003521562,-0.05410522,-0.010199477,-0.09255044,0.05202667,0.026053604,-0.082666084,0.035710223,-0.020996388,0.08373813,-0.07391453,-0.010915308,0.045114823,0.070021294,-0.019573767,-0.11955234,-0.01852506,0.0028447537,0.03387134,-0.07233145,0.03699776,0.020015618,-0.058536965,-0.086340494,0.008565919,0.05834191,0.007953659,0.03456738,0.017017432,-0.040963385,-0.046455745,0.03673933,0.03942418,0.017601091,-0.044263873,-0.10662706,0.07266771,-0.013112658,-0.006637809,-0.036813896,-0.0020796733,0.009216799,-0.033595655,0.122558475,0.0015508877 +1.14.20.3,Requires Fe2+. The enzyme is involved in the biosynthesis of the carbapenem beta-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. It catalyses a stereoinversion at C-5 and introduces a double bond between C-2 and C-3. ,384,1.0,-0.02455025,-0.03313634,-0.06495712,0.028977098,0.011474532,0.055782698,-0.09416243,0.017587455,0.056056008,-0.025869682,-0.01365286,-0.09653065,-0.04316106,0.0045485706,-0.011526614,-0.018894399,-0.08305979,0.043839097,0.03507158,0.024912236,-0.009374434,-0.0028835766,0.0077144424,-0.032502998,-0.030391267,0.04211617,0.054103997,0.0062745875,-0.029016506,-0.07797796,-0.0058222194,-0.069415115,0.07743984,-0.069956586,-0.0043251347,0.007786305,-0.03493104,-0.07412525,0.117472775,-0.037647717,-0.03621683,0.020385982,0.014506251,-0.013784274,0.0039279354,-0.03606474,0.039223086,0.012988552,0.026296148,-0.055656865,-0.010353591,-0.011413178,-0.085159875,0.016087202,0.032433487,0.012456434,0.035804156,-0.037605204,-0.0054088845,0.019952718,0.057386737,0.013403846,0.052389503,0.013397305,-0.054682054,-0.079783015,0.022834113,-0.07014946,-0.023443418,0.0073329424,-0.11193933,-0.090278246,0.012204824,-0.041147,-0.0040401756,0.01747881,0.027068025,-0.0124918595,0.07218234,-0.014710637,-0.00024251669,-0.027050791,-0.0063744765,0.0783211,0.014558317,-0.03980369,0.02778086,-0.035440963,0.027006585,0.084225245,0.054390036,-0.0054918304,-0.03269572,-0.027474295,-0.04975323,-0.011863191,0.015415321,-0.009062539,0.023282683,-0.04374907,-0.012847735,0.0492525,-0.0019953505,-0.08831561,-0.016397659,-0.016960029,-0.025297282,0.09813096,0.025976177,-0.0016524927,0.009332217,0.014033598,-0.023005921,-0.03288058,-0.09519954,0.061910383,0.037618656,-0.09176507,0.03338098,0.0039754496,0.05941417,-0.0009937357,-0.030645724,0.044757143,-0.08429154,-0.046087418,-0.07993332,1.26607455e-33,0.011044001,0.0086712865,0.049141534,0.017506134,0.047475796,0.028689316,-0.11116062,-0.003556088,-0.020293236,-0.0152134225,-0.088078015,-0.07461777,0.072148375,0.019806525,-0.005400671,0.0061289906,-0.108762324,-0.013048238,0.046357807,0.00313964,0.03355477,0.073394336,-0.0143374,-0.016752355,0.102052584,0.11801052,0.02457186,-0.006365696,0.040420998,-0.013492668,0.010856769,-0.057088323,-0.079899095,-0.0146938525,0.13037178,-0.0033068105,0.03919042,0.00069632236,-0.040338874,0.037372317,0.05702687,0.045176618,-0.03836231,-0.05392055,0.09447813,-0.037005655,0.0050566597,0.1123721,0.008327158,0.106776305,0.06969023,-0.04579818,0.018861229,0.07139737,-0.06221015,0.08224124,-0.054934755,0.015097225,0.023656098,0.001372753,0.051278945,0.059921924,0.051383566,-0.023283869,0.011084951,0.060923643,-0.06183555,0.018306715,0.026906343,0.09236612,-0.055674125,0.04579882,0.017444402,0.01648201,0.027830534,0.02217822,-0.09323339,-0.03893527,0.07642647,-0.011211753,-0.06196828,-0.005906754,0.08250704,-0.059498675,-0.028906928,0.0027834887,-0.114855796,-0.005036354,-0.010333618,0.046615355,0.061987672,-0.041223258,-0.08947521,0.07287257,-0.007910473,-3.9742854e-33,0.08327361,-0.15012242,0.122983955,-0.041089848,-0.046361387,0.0052211555,-0.08327656,-0.13176088,-0.0023727643,0.010799935,-0.0006935138,0.026257854,0.085318886,-0.030704102,0.049065556,-0.005078292,-0.039605618,0.065894775,-0.049028423,0.009272536,0.073124364,0.01206192,0.026942356,0.040846482,0.027135685,0.023639672,-0.018812763,0.0010464841,0.07381084,0.03561222,0.027070418,-0.06293758,-0.033562656,-0.09331053,-0.056420878,0.040042628,-0.015792811,0.03590393,0.051866964,0.061055847,-0.010303362,0.027751777,-0.022128386,0.083775595,-0.01463804,0.008194737,-0.03876625,0.03373631,0.018729066,-0.008052853,0.03562797,-0.072181605,-0.013398837,-0.050359007,-0.0018874207,0.010175551,0.04661257,-0.0069655613,0.03781722,0.038324613,-0.006773633,-0.029633824,0.056773197,-0.053120695,0.028941166,0.012373902,-0.025791494,0.088753775,0.08194531,-0.048091963,0.070628226,0.08098175,-0.026777063,0.06252887,-0.021544943,0.042055804,-0.02734189,-0.067037344,0.056091428,0.05218424,0.0037865061,-0.025480947,0.020674864,0.009953989,-0.0861662,-0.056519423,0.02471261,0.06057939,-0.008271289,0.025906388,-0.05089259,0.03255027,-0.017501801,0.08107974,-0.020357497,-3.7353683e-08,0.0051917187,-0.07001195,0.016524756,-0.035498075,-0.04482581,0.02792895,-0.07877348,-0.054765258,0.025785208,-0.081058465,0.037043896,0.06904029,-0.013383973,0.050142303,0.024363983,0.015300385,-0.0032928735,-0.033615142,-0.018607637,0.022777248,-0.15274024,-0.013736871,-0.091598675,0.015614114,0.0523649,-0.11808583,-0.029097656,0.023683917,-0.033251118,0.008858187,0.015884956,0.040830478,-0.067003,-0.031745985,-0.106330976,0.012886511,-0.05452987,-0.10794652,-0.03824951,0.037510082,0.06329329,0.008460151,-0.05987188,-0.030817203,-0.04774344,0.035513427,-0.04352171,0.020784575,-0.09066478,-0.0366231,0.038920455,0.012066467,-0.0484333,0.029918898,-0.06998924,0.060341723,-0.006698408,-0.03330231,0.03871459,-0.021334834,-0.046024572,0.022267785,0.17629056,0.008122087 +1.14.21.10,A heme-thiolate protein (P-450). The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.,384,0.9999999,0.0025149754,0.021080092,-0.073070645,0.007128703,0.016972812,0.08492098,-0.037924144,0.09604936,0.04584331,-0.006296819,0.017486745,-0.102086924,-0.04499147,0.09757754,-0.08236487,0.033606485,-0.008809601,0.05706848,0.000119214776,-0.10254979,-0.039300594,0.11244492,0.09533414,-0.0017023948,-0.020318568,0.010162637,-0.001273843,0.05381812,-0.009535881,-0.07647408,-0.04242676,-0.033218417,-0.035947975,-0.022313854,0.0068644504,0.08936217,-0.12988771,0.022548754,0.108395666,-0.0023404318,-0.017289924,-0.09355846,-0.08163444,0.012678802,-0.091010384,0.019987054,-0.016741056,0.037154444,0.072738945,0.033286814,-0.012351166,0.0095889885,0.02265601,0.052442465,0.080902,0.0038875858,0.043607563,0.04565005,-0.014606461,0.0269547,-0.015949933,0.03586757,-0.014237981,-0.022368569,-0.038386196,-0.020469556,-0.02943656,0.011831682,-0.038885705,-0.039563924,0.036051024,-0.0429041,0.0036459581,0.028856812,0.017828137,0.12590104,-0.044603206,-0.030457811,-0.05520509,-0.070555344,0.114341676,0.027604753,0.03316666,0.078960106,-0.040919535,-0.044155214,-0.020158226,0.034370944,-0.008898536,-0.028720057,0.075641625,0.055449273,-0.0011288316,-0.045146868,-0.012255745,0.043520775,0.010439778,0.036246926,-0.0198585,-0.035701707,0.022865266,-0.034573734,-0.038907334,-0.05367923,0.005608064,-0.038998414,-0.03679384,0.00457705,0.12212721,-0.054164227,0.00044806427,-0.03942557,0.10261768,-0.045696154,-0.014593862,0.029074136,-0.016666358,0.015344956,-0.027752502,-0.06635095,-0.009884059,0.022473542,0.02931688,0.03639913,-0.048424218,-0.03231974,-0.057924982,4.5794244e-33,0.11415857,0.036903486,-0.06479409,0.07469432,0.03619775,-0.08373113,-0.043067183,-0.0040811133,-0.013575398,-0.013724475,-0.11224349,-0.0775461,-0.04031075,0.017045511,0.004092281,-0.026783636,-0.058545906,-0.041206483,0.0029370768,-0.024555365,-0.03689186,0.0015764164,-0.046345074,-0.0109636225,-0.014830776,0.07529886,0.045173954,0.04682857,0.03018633,-0.042240616,-0.061565433,-0.030064017,-0.06731873,-0.055003602,0.036454014,-0.014615603,0.0105335405,0.027983751,-0.1066509,-0.030187313,0.022887038,0.09101464,-0.053264286,-0.07791936,0.060213905,-0.0036692456,-0.074415125,0.08174174,0.06016158,0.083195426,0.11186968,-0.06037392,0.0910588,0.041974336,-0.0392355,-0.009028428,-7.21397e-05,0.017742569,0.03684042,0.07717508,0.0047543333,-0.017319215,-0.035760347,0.02482884,-0.009307493,0.0010232183,-0.026389733,-0.08149531,0.0028836706,0.05711475,-0.028543973,0.032474354,0.0037548512,-0.044981476,-0.02279498,-0.020472297,-0.040147208,-0.007831112,0.013560681,0.0053333915,0.03390379,-0.035013366,-0.004832593,0.0013314115,-0.045950897,-0.05651238,0.009358753,-0.028830396,-0.0005626941,-0.026105404,-0.008759788,-0.08657099,-0.040864814,0.09418804,0.017102787,-5.093613e-33,0.07515561,-0.10095129,0.06605665,-0.031120097,-0.053678673,0.08457153,0.03733132,0.016902894,-0.025745654,0.009397339,0.13515432,-0.035560276,0.07881793,0.04676874,-0.027512062,-0.05465829,-0.023873352,0.061036617,-0.011679281,0.0869863,-0.049145922,0.039891932,-0.04097842,0.06152292,0.06758744,0.09484312,-0.0023303132,0.025799723,-0.059611153,0.0222204,0.0507314,0.03777082,-0.12233994,-0.026136836,-0.019625176,0.029699564,0.046446722,-0.0016217603,0.0058979657,0.006887959,0.0069761453,0.0776339,0.038054734,0.06903572,0.009646242,0.06516899,-0.07441556,-0.01800265,0.007923714,-0.09613176,0.0039474927,0.010689068,-0.030705964,-0.004817581,-0.028942263,-0.037046377,0.014981678,-0.01783245,0.04061738,-0.052376278,-0.076476775,-0.036510922,0.027306776,0.015544262,-0.026584696,0.07769974,-0.05527788,-0.036122613,0.1266381,-0.042598117,0.052752975,0.01142564,0.07147274,0.07501009,-0.010031259,-0.06747139,0.016437514,0.0012990513,0.0678618,0.06439099,0.0065957,0.018367022,-0.014524493,-0.048982278,-0.00268632,-0.04077608,-0.009847789,0.090281636,-0.011926994,-0.014922421,-0.009862621,0.052413717,-0.024654388,0.08069466,0.07133306,-3.542127e-08,0.007413143,-0.063788906,0.02547265,-0.038502045,-0.01745663,-0.014225213,0.05120579,0.01971805,0.0067779664,-0.06304377,-0.046507508,0.06438255,-0.09869177,0.050129607,0.019695133,-0.0014647996,-0.0065213502,0.07139885,0.02664634,-0.027375033,-0.03745585,0.028747695,-0.0090135485,-0.019216267,0.0052746683,-0.066466324,0.013961514,-0.038702317,0.047996577,-0.022662312,0.011143511,0.03653459,-0.03260796,-0.046238296,0.012630681,0.04042314,-0.017114898,0.0090584615,-0.027995642,-0.0125683835,0.0067541027,-0.05798205,-0.09484956,-0.0623075,-0.072168276,-0.059112247,0.009811525,0.08564142,0.001792145,-0.04785871,0.0402342,-0.020060895,-0.004399757,-0.06685495,-0.14281853,-0.056091513,0.027429543,0.0043141106,-0.052683283,-0.13075761,-0.017234584,-0.03702182,0.16849455,-0.021140173 +2.1.1.273,"While the enzyme from the plant Zea mays is specific for benzoate [6], the enzymes from Arabidopsis species and Clarkia breweri also catalyse the reaction of EC 2.1.1.274, salicylate 1-O-methyltransferase [1,5]. In snapdragon (Antirrhinum majus) two isoforms are found, one specific for benzoate [2,3] and one that is also active towards salicylate [4]. The volatile product is an important scent compound in some flowering species [2].",384,1.0,-0.059780765,0.034745485,-0.03850464,0.01647201,0.110034175,0.046020508,-0.025249043,0.0020660043,0.124070495,-0.07973503,0.092176326,-0.054839924,-0.03110174,-0.051167034,-0.007273148,0.06202096,-0.045090996,0.041031342,-0.068625234,-0.035504617,0.07780882,0.024507388,0.031766612,-0.0092386445,0.01565377,-0.11302339,-0.021574367,0.040391944,0.008923284,-0.09465553,0.12704553,0.067777686,0.016688619,-0.055715844,0.04826731,-0.0058651417,-0.025115397,-0.09470051,0.047829945,0.04602507,0.05330577,-0.017711384,-0.08038735,-0.0701248,-0.10594971,-0.0189775,0.05988876,0.016124072,0.011730485,-0.040281408,-0.08019043,-0.059499662,-0.060452074,-0.035914388,-0.06825508,-0.02313768,-0.034749664,0.0068710498,0.013316398,0.021893406,0.052055705,0.0033589106,0.029601442,-0.0037723775,-0.06624046,0.0029523154,-0.010952748,-0.047302186,0.10027896,-0.10243417,-0.08640382,-0.045885533,-0.04556768,-0.006774866,0.0049074152,0.0034901018,-0.036375135,-0.004551914,-0.02522994,-0.037317816,-0.06345888,-0.005600618,0.01873199,0.042413913,0.056767844,0.03513287,-0.004316,0.0037625316,0.064700104,-0.008183909,0.058887947,-0.042281,0.012480536,0.0067415093,-0.036275122,0.08607315,0.07052872,-0.007061195,-0.018569583,0.0034707258,0.039438806,0.04317832,-0.05877914,-0.12430659,-0.0025198343,0.02248353,-0.00133774,-0.023723966,-0.030759864,-0.036824048,-0.0052887867,-0.050972406,8.184974e-05,-0.029846687,-0.06103767,0.017917275,0.012966437,-0.06708452,-0.052416284,0.021024814,-0.007036683,-0.044632703,0.02520411,0.03197889,-0.030530374,0.05182316,-0.20960002,2.0634005e-33,0.010061609,0.066973224,-0.0068757134,-0.04703783,-0.031411372,-0.04193841,-0.025024818,-0.0067140437,-0.013839707,-0.08551717,-0.13384448,-0.0462664,-0.036768235,-0.000521554,0.0073048915,-0.017878663,-0.016155573,-0.025585238,-0.00740654,-0.028148146,-0.0037065581,0.008110913,-0.06981548,-0.043378178,-0.032238364,0.026021363,0.0003439393,0.0028769735,0.043388344,0.013985887,0.029063463,-0.05460513,-0.066807866,0.003913307,0.04909714,-0.0038530484,-0.045281243,-0.03946085,-0.020562325,0.027246382,-0.027511375,0.11506172,0.049067013,-0.022233274,0.018887123,-0.015765566,-0.06979187,0.10636017,0.15246096,0.0052762018,0.0025106175,-0.005006273,0.11057192,0.02442099,-0.06449976,0.03598196,0.014968202,-0.0034854845,-0.033217292,0.008912073,-0.10994858,0.056769326,-0.0018263588,-0.010184117,-0.051413067,0.051490486,-0.10410107,0.03499048,-0.0009960587,0.0601142,-0.016825605,-0.0075011984,0.043776203,0.025339877,0.05586083,-0.10675847,0.0073938696,0.031049743,0.10130995,0.06430768,0.020790162,-0.021648197,0.00799734,-0.015677897,-0.0675743,-0.07160016,-0.060286887,0.019004127,0.0026416539,0.13110954,0.026821513,-0.012551775,-0.007082535,0.0015137369,-0.027524112,-3.4607608e-33,0.029897504,0.04331621,0.073547006,-0.037828848,0.025877673,0.072503366,-0.031729728,-0.014464891,-0.0435791,-0.013835825,0.0005634827,0.002291384,0.035180025,-0.017873924,0.014809966,0.031727996,0.13007234,0.09053979,0.0062761237,0.00039365533,-0.10037828,0.008119749,0.021379318,-0.00099243,0.033522025,0.003558262,0.09455718,-0.017694429,0.00743165,-0.0119272275,0.029786034,0.039842594,-0.061791692,-0.011034823,-0.012113475,-0.029301943,-0.0294528,-0.009569361,-0.011858311,0.040081624,-0.015705265,-0.081062816,0.08027584,0.11817055,0.050359465,0.05534987,-0.040795527,0.039092783,-0.07587931,-0.053173658,0.024479102,0.041130397,0.0020331007,0.07098794,0.05843352,0.037223198,0.04437238,-0.01383045,-0.06277702,-0.051065143,0.01559585,-0.037409086,-0.011178967,-0.0076695313,0.061512586,0.008258565,0.0044899643,0.020389562,-0.049064543,-0.018925887,0.097185686,-0.013676928,0.024067646,-0.019498834,-0.08270403,0.00949803,-0.04453437,-0.054792903,-0.027527487,-0.09100432,-0.014727568,0.022544444,-0.025832135,-0.12909691,-0.024519967,-0.049498115,-0.009157691,0.10981195,0.03693291,-0.012516747,-0.026570395,0.010683283,-0.04057795,0.045619402,0.12068468,-4.2134978e-08,-0.04085748,-0.13312846,0.051831722,-0.06886403,-0.06612941,0.012043065,-0.015146791,0.035985596,0.004546983,-0.0024336337,0.065332785,0.072109215,0.020516502,0.043585394,0.020390464,-0.023547782,0.06188307,0.067537166,0.0029825103,0.062202826,-0.027842693,0.029001718,-0.055006504,0.0013707927,0.009291036,-0.057005532,0.047170635,0.06360488,0.014432315,-0.064672776,0.061167426,0.022587264,0.0689672,0.04083007,-0.08492881,0.015964974,0.042498615,-0.022622809,-0.038457774,-0.004947217,0.054086838,-0.009922926,-0.017595505,-0.011354933,0.02335649,-0.008458808,0.06303001,0.041587923,0.0340641,0.02114683,-0.010376521,-0.013347547,0.021812003,-0.02824233,-0.057593945,-0.007185381,-0.01442205,-0.04114926,0.0881276,-0.027883094,0.09042999,0.005476919,0.09946914,0.027056206 +2.1.1.274,"The enzyme, which is found in flowering plants, also has the activity of EC 2.1.1.273, benzoate O-methyltransferase.",384,0.99999994,-0.03954266,0.02466287,-0.03891141,0.014824816,0.07322262,0.10604314,-0.046961937,0.035153475,0.09991653,-0.060994353,0.0750717,-0.06871141,-0.06756086,-0.017427683,-0.01907376,0.069880255,-0.06949623,-0.010132942,-0.059937637,-0.039019115,0.06422701,0.048395645,0.021200614,0.04234553,0.027377324,-0.035512745,-0.005127453,0.0010428802,0.022178698,-0.11155184,0.045819443,0.008285157,0.05330759,-0.016447987,0.04595167,0.028430995,-0.004338094,-0.13800722,0.002543603,0.034159206,0.057240903,-0.0021077706,-0.03427899,-0.06914102,-0.012186657,-0.029900376,0.07049903,-0.03555119,0.0072960337,-0.047106516,0.011106525,-0.08699544,-0.022325357,-0.020249564,-0.016828816,-0.005072105,0.004259514,0.07007347,-0.031122042,0.062310394,0.08073094,0.038737822,0.02071747,-0.003517152,-0.057990458,-0.035909027,0.011406564,-0.042530566,0.046249744,-0.061151646,-0.104716055,-0.08208575,-0.028945189,0.048035663,-0.013761455,0.0101011,-0.033330437,-0.0320195,0.04070511,-0.039357275,-0.005024702,-0.05147787,-0.06521453,0.009114276,0.037269086,0.022345651,0.018240737,0.05681189,0.06587168,0.03410474,0.023351252,-0.06274848,-0.035443984,0.000916682,-0.035883058,0.071760245,0.05747262,0.048228778,0.04533911,-0.04030342,0.012661624,0.13329203,-0.06338041,-0.042007864,-0.01833971,0.027238209,0.03180595,0.03681665,0.0067559793,-0.0511361,-0.013308967,-0.07199195,0.040041264,-0.0035548513,-0.026770934,0.049325973,-0.025708068,-0.090313904,-0.019465545,0.046428785,0.047024537,-0.056178685,0.05927713,0.0830451,-0.039640848,0.06491591,-0.17042276,-3.0970507e-33,0.06414947,0.03046771,0.03795973,-0.019479027,-0.022966264,0.003967012,-0.08119875,0.034759857,-0.053224232,-0.14661977,-0.092781305,-0.043785755,0.060932744,0.03626931,-0.0031807688,-0.035938315,0.028036298,-0.0040324708,0.041754644,-0.00313281,0.049650803,-0.036968403,-0.09989971,0.021306463,0.01939884,0.035196442,-0.003962552,-0.018796172,0.035369717,-0.012034806,0.011300787,-0.13109165,-0.06985206,0.0779144,0.029585505,-0.009660907,-0.013784894,-0.025021192,0.018934885,0.04460477,0.032988317,0.06753335,0.08131613,-0.0033084664,0.04594005,-0.0017794701,-0.06287633,0.088026956,0.12541267,0.03745007,0.016135555,-0.02545765,0.083309956,0.00842567,0.002497682,0.033194378,-0.043779004,0.03234498,0.011837417,0.03183089,-0.026399054,0.06814123,-0.05630251,-0.00870528,-0.0050755977,0.029760636,-0.12320242,0.016698917,-0.027035672,0.07281621,-0.056300912,-0.026269088,0.07243749,0.0015113008,0.082651,-0.04861452,-0.059743777,-0.0030576978,0.027878243,0.05802466,-0.017698683,-0.037401803,0.036297128,-0.051091306,-0.05783302,-0.036076616,-0.025274796,0.038279694,-0.037515935,0.11180386,0.039690923,-0.03620579,-0.019482926,-0.011762044,-0.018870253,1.0041999e-33,0.031302646,0.021798687,0.049965724,-0.061301015,-0.004850914,0.06784403,0.0025108666,-0.020761477,0.0052085035,-0.007854002,0.06226438,0.023630863,0.079411134,-0.057407178,0.054988828,-0.037411638,-0.03534321,0.09483159,0.034418873,0.04293665,-0.08618989,0.019206116,0.0055078915,0.004572645,0.040727228,-0.004810989,0.023236623,-0.0046539116,0.014144931,0.0087780375,-0.04936588,-0.00019532075,-0.07369358,0.015521522,-0.01634333,0.01465937,-0.016750151,-0.06523161,-0.009748754,0.0350375,-0.05146247,-0.012451175,-0.010919685,0.073878385,0.05530157,0.09480376,-0.048729002,0.061790958,-0.040811997,-0.046311118,0.012236226,0.02169653,0.009830674,0.06579023,0.037693087,0.0019861613,0.017516036,0.035381082,-0.05667441,-0.016326379,0.01580821,-0.03579197,0.0040928526,0.031325825,-0.046433553,0.0013923942,-0.0355711,0.06931625,-0.041066445,0.026748436,0.0750616,-0.0020288415,0.0066057756,0.04081452,-0.06458289,-0.023637583,-0.05171051,-0.06297456,-0.024112985,-0.06757405,-0.0060477154,0.034746006,0.01668393,-0.14077629,-0.004121935,-0.08124411,-0.016790949,0.087975055,-0.019392334,0.016474517,-0.09530368,-0.018145448,-0.08913694,0.065524995,0.070121914,-2.933806e-08,-0.049258966,-0.10824704,0.063571304,-0.09476573,0.050306227,0.006900315,0.003707241,0.034231976,0.03318603,-0.0043640425,-0.022440845,0.04089119,0.016806616,0.007900095,0.036940567,-0.044570506,0.086338945,0.07295063,0.0022083183,0.05294709,-0.03283196,0.025028123,-0.11883819,-0.014593357,-0.0032131027,-0.040904813,0.030686019,0.09610373,-0.01982861,-0.05919049,0.048412997,0.018611234,0.06377102,0.01708316,-0.10482403,-0.002127993,0.0036061252,-0.021650638,-0.093499005,0.029178996,0.05556302,-0.06881613,-0.01979051,-0.023459774,0.061273504,0.0137052685,0.07184516,0.027525328,0.008836327,-0.02403781,0.038798034,-0.040130403,-0.022197502,-0.09450619,-0.083309434,-0.020085055,-0.019394442,-0.076202966,0.017115818,-0.03238664,0.0060712877,0.03345887,0.16706349,-0.017199295 +2.1.1.275,"The enzyme also methylates gibberellins A20 (95%), A3 (80%), A4 (69%) and A34 (46%) with significant activity.",384,0.99999994,-0.012153943,-0.059128594,-0.07799876,-0.006549691,-0.03545722,0.0052979607,-0.0024845796,0.023943264,-0.02086063,-0.0019668809,0.07474688,0.042815894,-0.06437801,0.027190633,-0.038034905,0.12956047,-0.004728548,0.0047188927,0.0029591122,-0.07004742,0.0219308,-0.0038955612,0.06434735,0.013368803,0.018143037,-0.009288772,-0.0055277357,-0.00398249,-0.015988266,-0.056246135,-0.020072589,0.018091422,0.11247511,-0.025291385,0.020240514,0.10769265,-0.029771313,-0.024647366,0.062261697,0.013258916,0.08730039,-0.018374471,0.009021514,0.013644884,-0.03799298,-0.00091609766,-0.026092239,0.009722759,0.032180108,0.04324378,-0.07288293,-0.08850266,0.016010655,0.02184812,-0.020290172,-0.020147512,-0.06692897,0.004371414,-0.049706616,0.010653654,-0.027224373,0.006639025,-0.01697496,-0.052213773,0.0047204746,0.014456705,0.030348659,-0.049288712,-0.037866797,-0.005246053,0.03658439,-0.07950984,0.012308626,-0.010576896,-0.007296697,0.035169445,-0.0011758333,-0.03794733,0.0016534526,-0.058013923,-0.0015969881,-0.0009102595,0.06933926,0.055128034,0.0343099,-0.004580913,0.015526747,0.13054833,0.011546707,0.0802146,0.042426065,-0.0015011942,-0.049272936,0.006635757,-0.026718454,0.0138120735,0.030846484,-0.008174485,-0.014933975,-0.03773502,0.02966333,0.04440943,-0.06607945,-0.09477268,0.005044228,0.03489602,0.04809625,0.06691779,0.024125181,0.008653775,-0.023709288,-0.0016562685,-0.015096416,0.008687362,-0.039102793,0.09313299,0.015690522,0.011687973,-0.053165995,-0.018778382,0.0346956,-0.014631043,0.066545874,0.038658448,-0.04916738,-0.008571799,-0.20314716,-4.3056007e-34,0.0416908,0.09576726,-0.054645583,0.04309463,-0.03144002,0.075090215,-0.07341568,-0.010627404,-0.02296363,-0.040477976,-0.1823242,-0.075598784,0.05560979,0.032928307,0.022468926,0.049503483,0.009277909,-0.026394136,0.055909406,-0.042977247,0.022545097,-0.0041458085,-0.10844846,-0.015673561,0.0059355423,0.03989531,0.022367349,-0.038600877,0.008607561,-0.04073209,0.030044243,-0.0634642,-0.06042767,-0.038238753,0.1024743,0.038283844,-0.029782156,0.025763117,0.008634515,0.11351993,-0.030758968,0.010192248,0.012055004,-0.031934146,0.075399,-0.07397354,-0.091563605,0.05355772,0.09651961,0.08526821,0.048481908,-0.019869812,0.055728644,0.06680557,-0.061394952,0.0001459546,-0.055083077,0.01951626,-0.021661144,0.012124799,0.02474095,-0.054425657,-0.02882221,-0.05647583,0.009308356,0.000866967,-0.089109264,-0.05271411,-0.09518057,0.10559499,0.006644449,-0.086092435,0.10072416,-0.013927892,-0.045761567,0.0120643405,-0.0042371037,0.005306344,0.037094377,0.051539965,-0.021219948,0.033053745,0.011870941,-0.052433286,-0.14468235,0.030235596,0.06401767,-0.011906572,-0.03274339,-0.010409228,0.102905326,-0.05014845,-0.025592182,-0.012061351,-0.051249173,-4.1678447e-34,0.032470386,-0.015123237,0.04907123,-0.060691092,-0.06059397,0.044951014,0.08544732,-0.07162311,0.05021556,0.0034809108,0.07420718,0.029896664,0.00783778,-0.030815,0.026270147,0.11448578,-0.026158514,0.111278646,-0.029492503,-0.014602315,-0.06997779,0.1352754,0.0077814334,0.08313327,0.013690629,-0.010992848,0.0025377583,0.01932316,0.074044034,0.008282289,-0.046137925,-0.0016628694,-0.03062299,-0.030989327,0.047498353,0.078510165,-0.023306029,-0.018789997,-0.07400962,0.06641645,0.0061225994,0.032699537,-0.020191958,0.09085658,0.029195236,0.082910195,-0.016625509,0.052815754,-0.036778126,-0.014535298,0.06977938,-0.01689288,0.03758655,0.053272247,0.08607356,0.0018138221,0.0027373424,0.019991573,-0.10164689,-0.049675006,-0.014086997,-0.037781786,0.051985677,0.016618645,0.018351577,0.055121806,-0.025443515,-0.0070171314,0.029864244,-0.014549224,0.029905913,0.024678946,-0.047943212,0.030437334,-0.03118263,-0.042780124,-0.066378675,-0.08924608,-0.04317199,-0.096337505,0.019162303,0.026591657,0.014779985,-0.07653268,-0.02969701,0.0027038192,0.000643698,0.084915906,0.016715363,0.005742298,-0.013236188,0.0020542082,-0.083824016,0.05314407,0.053233895,-3.604777e-08,0.04476753,-0.03504218,-0.020962076,-0.09325765,-0.050294552,0.0795331,-0.008624016,0.031275265,-0.008352545,-0.004344433,-0.046383686,0.041579805,-0.055699058,0.0015680934,0.009030535,-0.034336083,0.01667634,0.05259872,-0.017445745,-0.041824974,-0.049616575,0.047278974,-0.10754426,0.014882589,-0.057581943,-0.04276079,0.03165567,0.06346424,0.027716538,-0.024941722,0.05242231,0.013219612,0.050205376,-0.08843247,-0.01653347,0.0470221,-0.009643909,0.013698835,-0.015604621,0.09298295,0.031208763,-0.10415339,-0.038224474,0.024302965,-0.024881832,-0.09684238,-0.007591765,-0.05799043,0.044534292,0.043588176,0.07675965,0.042726785,-0.02236573,-0.030029772,-0.10687686,-0.024846118,-0.018293312,-0.04793982,-0.007414382,-0.10128997,0.012100093,0.001581814,0.12221234,-0.052284162 +2.1.1.276,"The enzyme also methylates gibberellins A34 (80%), A9 (60%), and A3 (45%) with significant activity.",384,1.0,-0.034356963,-0.06541553,-0.0863562,-0.0067165946,-0.017251674,0.007803089,0.004245637,0.022289256,-0.027496722,0.00042583988,0.07948504,0.024045838,-0.0688301,0.035931718,-0.017978717,0.10733965,-0.016385386,-6.5231914e-05,0.0060188863,-0.07585749,0.02309644,0.0065490725,0.071902506,0.009809297,0.040834986,-0.0035431453,-0.010065423,-0.0047332374,-0.016822962,-0.06051253,-0.020256246,0.027918143,0.103477016,-0.024799967,0.015491173,0.11259969,-0.041765254,-0.023228511,0.050707437,0.020158289,0.0919062,-0.015146258,0.010858878,0.026201306,-0.049082585,-0.0025550257,-0.023132026,0.016806133,0.030356172,0.043806165,-0.08077675,-0.10574394,0.016487747,0.0095142415,-0.029247897,-0.020488078,-0.048505686,0.006949057,-0.05545278,-0.011549385,-0.037925664,0.008492042,-0.012100564,-0.057010707,0.0123468265,-0.002420582,0.029106656,-0.062218845,-0.037163027,-0.011875355,0.04209973,-0.07073016,-0.0017209639,-0.01140627,-0.0043054987,0.047081996,0.0052614524,-0.03562158,0.005932511,-0.03707747,-0.0010943037,0.013207603,0.06553361,0.0632248,0.03687676,-0.020232966,0.021083076,0.13339922,0.016275259,0.08045102,0.035599887,0.0057509895,-0.04619287,0.0028936036,-0.019575536,0.016163029,0.027316736,-0.007313825,-0.023221485,-0.040030286,0.026490271,0.04702648,-0.053381927,-0.079611525,-0.00012212465,0.040513013,0.025269797,0.07463993,0.0143580595,0.0062270733,-0.029135684,0.008215569,-0.0059666107,-0.0013577539,-0.03469389,0.08032738,0.01420803,0.0059217303,-0.043021422,-0.018769644,0.025663218,-0.004936617,0.055793755,0.038848393,-0.042789783,-0.0013481198,-0.19999337,-1.1412255e-33,0.025082843,0.08766996,-0.06664059,0.036878593,-0.028390974,0.07230516,-0.08844426,-5.944482e-05,-0.03309491,-0.040383574,-0.19267286,-0.07915464,0.05810361,0.034184165,0.028665232,0.053246003,-0.0035511996,-0.011150515,0.04625648,-0.044791903,0.0059487717,-0.0036068226,-0.10669118,-0.017405262,-0.009068129,0.031073656,0.019940658,-0.03449752,0.012366151,-0.04691105,0.03512888,-0.05950223,-0.053658787,-0.041720647,0.108974144,0.058045927,-0.019619057,0.013177487,-0.0014171184,0.11771468,-0.026909117,0.012806029,0.016534606,-0.033482105,0.07694177,-0.06944133,-0.085090406,0.047891308,0.090969495,0.07560717,0.058463383,-0.016392335,0.05065178,0.07007081,-0.06401527,0.004935919,-0.042189308,0.027177628,-0.02801936,0.011149313,0.016537782,-0.050982088,-0.007661044,-0.06531992,-0.0049648876,-0.0036393984,-0.09219576,-0.05066325,-0.08154529,0.12040954,0.0019869134,-0.079257056,0.09666727,-0.016871244,-0.03718888,0.022926651,-0.0087989485,0.0069759972,0.047579054,0.045260992,-0.01152113,0.022240147,0.003301606,-0.036091518,-0.15025076,0.037927832,0.06541548,-0.014046041,-0.03337401,-0.016623031,0.10885753,-0.052434724,-0.019720947,-0.015620651,-0.05153737,3.3031515e-34,0.02621365,-0.01875907,0.042629242,-0.061560944,-0.058845088,0.040473223,0.068525665,-0.07538302,0.037649337,-0.00829392,0.07201262,0.015499793,-0.0013150097,-0.049032412,0.02768924,0.10494122,-0.016271245,0.1205582,-0.031136326,0.0029601518,-0.06611624,0.13051677,-0.0011217354,0.093601175,0.0040898947,-0.014619654,0.003535926,0.028120415,0.09342317,0.005352502,-0.056710575,-0.012341407,-0.034837313,-0.038240146,0.041506022,0.06625503,-0.02231427,-0.008730225,-0.042438786,0.060258843,0.027565246,0.032236546,-0.016511206,0.10305512,0.028305586,0.100556344,-0.007993671,0.052461006,-0.04871991,-0.011394846,0.069481544,-0.019271998,0.053996664,0.055985145,0.078788675,0.019707216,0.0018462974,0.011708037,-0.087028585,-0.041138794,-0.01341993,-0.025492284,0.046467803,0.0050344192,0.016044203,0.04425555,-0.025863944,0.0015302025,0.041613374,-0.030688783,0.03747817,0.037301034,-0.03846446,0.03292909,-0.016400589,-0.05819167,-0.061279673,-0.065602735,-0.02155787,-0.08732878,0.02319198,0.02558856,0.018242966,-0.08050192,-0.02264564,0.0055357506,0.0043577203,0.08228806,0.03328655,-0.0020958444,-0.019038506,0.013464292,-0.0866498,0.053289335,0.0637634,-3.2641704e-08,0.04948089,-0.04744069,-0.024179539,-0.090490624,-0.05088994,0.083213575,0.009605496,0.029985406,-0.015150869,0.006812244,-0.026855916,0.032606848,-0.0670285,0.009147613,0.016868388,-0.028862998,0.017491467,0.051852334,-0.01645327,-0.034318313,-0.07227452,0.055537738,-0.09083829,0.021625753,-0.06409654,-0.033079017,0.025672749,0.08364066,0.020156194,-0.022195144,0.039440285,0.009483735,0.040162113,-0.08429344,-0.022957126,0.050720606,-0.00072241004,-0.0051528257,-0.004692838,0.08661669,0.03382772,-0.09169798,-0.05397316,0.02140718,-0.039005913,-0.09550731,-0.017315337,-0.05344385,0.042539336,0.04649975,0.08327883,0.04118175,-0.024952233,-0.022554468,-0.12081167,-0.046190977,-0.01771506,-0.06559436,-0.024146957,-0.09475582,0.022705976,-0.0036420298,0.13196784,-0.056914475 +2.1.1.277,"In the plant maize (Zea mays), the isoforms AAMT1 and AAMT2 are specific for anthranilate while AAMT3 also has the activity of EC 2.1.1.273, benzoate methyltransferase.",384,1.0,-0.063125744,-0.02089525,-0.057188366,-0.010710013,0.08008502,-0.031365637,0.00594072,-0.024842786,0.032608442,-0.0021690628,0.14349337,-0.0501618,-0.064343885,-0.035844754,-0.0073179193,0.08958197,-0.015845833,0.058051836,-0.020781342,-0.05090516,0.051823284,0.06827208,0.024550563,0.007919458,0.020186048,-0.059990607,-0.068449415,0.11680638,0.056378875,-0.11216484,-0.012917638,0.06850978,0.0020567065,-0.03729722,0.013841802,-0.017047673,-0.04895102,-0.07243769,0.01905592,-0.017650723,0.038745303,0.008818074,0.019528966,-0.046839222,-0.066303976,0.026981186,0.022061775,-0.022648487,-0.045767203,-0.05608246,0.04875278,-0.04633324,-0.08676139,0.028468424,-0.0500426,-0.075161174,-0.060392965,0.072542466,-0.043086037,0.11636103,-0.027612694,0.048404343,-0.05841282,-0.033952102,0.006071387,0.022615548,0.055663265,-0.05444807,0.012838285,-0.0023831124,-0.065554835,-0.047626715,-0.021493794,0.05145193,-0.066754855,0.072552904,0.02304552,0.0099092815,-0.0007989641,-0.040061336,-0.035869505,0.02225022,0.07431344,0.0013241735,-0.042113546,0.0074787945,-0.07027387,0.13121635,0.032143522,0.003919215,0.05604667,0.040433604,-0.0033632347,0.097286165,-0.019325431,0.054069556,0.11070661,0.00476088,0.058314845,-0.019054225,0.016196428,0.10007978,-0.12718356,-0.007159937,-0.008446006,-0.018928532,0.023229381,-0.035434708,0.017193053,0.041990872,-0.018870188,-0.033455487,-0.010783422,-0.0099623175,-0.05741521,-0.029413974,-0.02055334,-0.07064106,0.0261817,0.03886594,-0.0401561,-0.03463342,-0.029137697,0.04003034,0.029008694,-2.7751475e-05,-0.12229895,2.2357467e-33,-0.035495628,0.088748544,-0.021650057,0.040985525,0.003700559,0.029043756,-0.012583312,-0.056840185,-0.016021438,-0.06952829,-0.088349,-0.057733417,0.0076365103,0.025310857,-0.037312414,0.008476602,-0.04822541,-0.050911054,-0.034357462,0.028173627,-0.03031957,0.02622587,-0.11684107,-0.042635474,0.07179066,0.050465457,0.0046748156,0.0068091787,-0.015156669,-0.01480008,0.06281105,-0.03204593,-0.11219876,0.0116067855,-0.0004199669,0.050166126,-0.008648125,-0.031808663,-0.052417863,0.03971553,0.0044783684,0.13833061,0.053024806,-0.006675526,0.067206,0.03940472,-0.059965547,0.11717818,0.10352141,-0.0074943644,-0.00094129285,0.03300398,0.035720628,-0.08001842,0.032178435,0.057238426,-0.041104402,0.0364244,-0.05982963,0.03850288,-0.025235271,0.020685906,-0.022304686,0.047458015,-0.029915847,0.0714991,-0.11750647,-0.042107064,0.044979595,0.07563577,-0.0059576943,-0.06431121,0.096100256,0.04234093,-0.033567596,0.0018028667,0.012666734,-0.022170633,-0.034800198,0.060649194,-0.020142952,-0.022866782,0.026238088,-0.08108446,-0.10728026,-0.033076175,-0.033357237,-0.013686383,0.048013832,0.07125608,0.071148604,0.008645353,-0.056528423,-0.02527855,-0.037123032,-2.9523303e-33,0.04138687,0.107321575,0.02698918,-0.05357554,-0.038577173,0.039729968,0.010424541,0.0011799699,0.044016816,0.052653756,0.06328626,0.079754375,0.009230438,-0.05038706,-0.005947723,-0.07963482,0.006893165,0.057801798,0.11055705,0.08869466,-0.108035356,0.08255451,-0.04428495,0.0044349916,-0.0024146077,-0.001217431,-0.017140232,0.036028657,0.024398344,-0.100198254,0.011038504,-0.041135523,0.0052771736,-0.015850734,0.0028245922,0.002463791,0.00035457744,0.004259069,-0.06653103,0.02085393,-0.025077397,0.038793083,0.011018949,0.041170802,-0.02285411,0.081216566,0.014254837,0.0027522652,0.017831385,-0.030616993,-0.002028016,-0.043535676,-0.04052488,0.042268936,0.09421338,0.0061783455,-0.007450166,0.014304556,-0.09385122,-0.013723956,0.057180542,0.0009375602,0.042882115,-0.028580267,0.025769733,0.030762577,-0.0031438118,-0.014378981,0.03996616,0.09292218,0.021402977,0.038227797,0.008843242,-0.068659484,-0.07602168,-0.013618734,-0.04866247,-0.05235564,-0.09441196,-0.12434169,0.011599125,0.04596079,-0.03427267,0.026609616,-0.005390048,0.053036023,-0.023861572,0.12820582,0.011756039,-0.014164047,0.03586476,-0.030080473,-0.00992319,0.045879878,-0.008308515,-3.1630837e-08,0.042104017,-0.087646194,-0.027133662,-0.0692967,-0.11049859,0.01284166,-0.02827043,0.06151859,0.057953294,0.062390633,-0.03343686,0.07405092,0.010420556,0.04515718,0.019198788,-0.032113362,5.524952e-05,-0.0011940273,-0.005469727,0.046222754,-0.108128615,0.019406686,-0.07331476,-0.01544465,0.044499725,-0.014770459,-0.003625509,0.04069338,0.055630956,0.0070521347,0.017468251,-0.0017390564,0.069890514,-0.0053368425,-0.0598872,-0.0046511153,0.00560983,-0.033771515,0.01962225,-0.014845345,0.10632692,-0.06950196,0.0043494343,0.014662595,0.049785662,-0.08421958,-0.0020194103,-0.06199199,0.017931512,-0.0728466,0.026390065,-0.04051279,-0.010688055,-0.09491544,0.015119015,-0.026677376,-0.027433831,-0.0031633433,0.08184782,-0.016625408,0.053093456,-0.0065113613,0.09334603,-0.020382153 +2.1.1.278,"Binds Mg2+. The enzyme is found in plants and is important for regulation of the plant hormone (indol-3-yl)acetate. The product, methyl (indol-3-yl)acetate is inactive as hormone [2].",384,0.99999994,-0.07387889,-0.074254625,-0.04470012,0.043232985,0.08174344,0.09333012,0.013639514,-0.041957717,0.014534685,0.017068459,0.1287098,0.016697882,-0.0410964,-0.065148056,0.0057830727,0.07264032,-0.049533263,0.061652564,-0.0008319585,-0.059863612,0.07744452,0.027460441,-0.029256754,-0.026504792,0.005859143,0.047715425,0.0017389983,-0.035360985,0.02315314,-0.051758245,-0.038759265,0.06328096,0.07335517,-0.024120836,-0.045996636,0.08590524,-0.007545017,-0.12834172,0.025274202,-0.011916146,0.02849361,-0.03927546,0.051165737,-0.047500428,-0.004688148,-0.039214917,0.05646855,-0.023533076,0.046140537,-0.019748826,0.009520208,-0.057788838,-0.0024756799,0.0047070985,-0.024712326,-0.006361983,0.025229294,0.054131184,-0.05156407,0.053695727,0.048529338,0.033805605,-0.09576096,0.0057022627,0.033811938,-0.037851706,-0.017611105,-0.034196384,0.04904384,-0.026029889,-0.014199303,-0.08844158,-0.018508084,0.019903269,-0.031343665,0.027750827,-0.027626844,-0.073597595,0.05256462,-0.024302168,0.0077446043,0.04411379,0.06671803,0.07991076,-0.007007599,0.01873607,0.020723132,0.053055793,-0.010302256,0.060725816,0.07141612,0.0033586523,-0.007381147,0.020245738,-0.031962354,0.07894252,-0.017484076,-0.027462123,-0.031298377,-0.01361894,0.008059838,0.068558134,-0.10917129,-0.02495164,-0.06667606,0.049592763,-0.054999754,-0.04677256,0.0033415996,0.05783975,0.0029404731,-0.011185873,-0.006414183,0.082365416,-0.008349333,0.053312566,-0.012709668,-0.070613585,-0.020056525,-0.082360476,-0.011174447,-0.0034111869,0.014672991,0.06872716,-0.01623724,0.04342599,-0.105160214,-1.3502555e-33,0.032726415,-0.0058377064,0.012248415,0.01855306,-0.02668941,0.031849645,0.002521769,-0.02311613,-0.011406943,-0.030279992,-0.104817435,-0.08493473,0.002349327,0.01591475,-0.027020672,-0.064815626,-0.0054813405,-0.0028113197,0.11319761,0.04479697,-0.042314447,0.063178964,-0.053736664,-0.045244087,0.009866381,0.088403046,0.042894505,-0.032721553,0.04824263,-0.017498683,0.08352484,-0.099980675,-0.021930998,0.08364839,0.029728167,-0.06354055,0.0022059537,-0.052350387,-0.025406022,0.03109749,0.025394253,0.039847,0.03988598,0.044224393,0.018390624,-0.047323845,-0.05144669,0.063253485,0.038558677,0.08773436,0.028183516,0.031920385,0.07732569,0.022774283,-0.03415421,0.059192818,-0.08285536,0.018406648,0.008341639,0.028567128,-0.049145173,-0.004067267,0.039823394,0.03539171,0.050447755,0.11214745,-0.117931046,-0.106773764,0.0086676935,0.14772153,-0.014686342,-0.09561095,0.06451747,0.0428097,0.04320915,0.0016589559,-0.04179979,0.034172844,-0.04831846,0.034049124,0.0041237846,-0.043515917,-0.023991564,0.039441798,-0.08278225,-0.07120573,-0.035625763,-0.03433424,0.029341659,0.0114008095,0.06425557,0.017338095,-0.024678433,0.07227508,0.017834777,-1.939668e-34,0.080004044,-0.059458524,0.090985775,-0.07871486,-0.106679454,0.0514461,0.001682459,-0.13597335,0.046265125,0.05959574,0.09488585,0.04666461,-0.004252067,-0.034772284,0.030719154,-0.060671348,-0.027439136,0.09065675,-0.06720802,-0.0135531975,-0.035499915,0.064825445,0.003703289,0.06868399,0.027337624,-0.018903872,-0.007797847,0.011509905,-0.01190741,0.03769968,0.039022196,0.0045611914,-0.089850046,-0.034824304,-0.022601059,-0.00042683285,-0.037857287,-0.043056335,-0.055740237,0.061608966,-0.004756988,0.09512371,0.03534849,0.043717407,0.08649247,0.023396494,-0.00030585512,0.07952746,0.0063784546,-0.04021398,-0.021409772,-0.06516571,0.0084277205,-0.061097715,0.06817441,-0.0024536657,-0.03330655,-0.019477876,0.012085821,-0.030478794,-0.013901106,-0.021487048,0.03983674,-0.007418119,-0.044607148,0.051551756,0.0799894,0.04937977,0.04414032,0.07769239,0.060928013,0.024656788,0.09199503,0.083190195,-0.034193333,-0.016153928,-0.04736988,-0.06697467,-0.034931995,-0.0831418,0.021026473,0.047812972,-0.07121211,-0.07323916,-0.028861115,-0.043200746,-0.035570476,0.13343015,0.05854908,-0.015431569,-0.0806963,-0.012598931,-0.12904763,0.017393228,0.04154367,-3.3466033e-08,-0.03219247,-0.05372158,0.0555433,-0.10472893,-0.026540337,0.054211173,-0.010740919,-0.0040022647,0.07844122,-0.019424066,-0.007934586,0.045775004,-0.038472448,0.0188788,0.005218853,-0.03947546,0.058010027,0.049557623,-0.025044799,-0.03084481,-0.012080765,-0.034274094,-0.093095325,0.041695815,-0.0017707294,-0.091559894,0.028842065,0.10999615,0.0061333617,0.01323177,0.09060338,0.016772356,0.002611014,-0.005180725,-0.04617109,0.030616991,-0.022281287,0.007313963,-0.026380125,-0.019717082,-0.047423434,-0.05642253,0.03875944,-0.029074013,-0.049441747,0.0035329047,0.057897203,0.02718316,-0.0038006585,0.0312868,-0.014330746,-0.021694416,-0.009182776,-0.07486482,-0.0557745,-0.045513418,-2.0300773e-05,-0.070090055,0.02376939,-0.061058667,-0.074041225,0.009289407,0.070859075,-0.041596353 +2.1.1.279,"The enzyme from anise (Pimpinella anisum) is highly specific for substrates in which the double bond in the propenyl side chain is located between C7 and C8, and, in contrast to EC 2.1.1.146, (iso)eugenol O-methyltransferase, does not have activity with eugenol or chavicol.",384,1.0,-0.038599793,-0.032281037,-0.076204576,-0.008148134,-0.01593289,0.08930902,-0.100102864,-0.00211596,0.043578025,-0.021388294,0.10176362,-0.030372554,-0.058112398,-0.017055072,-0.06204849,0.061187625,-0.047104344,-0.007348523,0.03734599,-0.057200562,-0.03152482,-0.0463691,0.017032249,-0.010802636,-0.06878619,-0.062550396,0.031049449,0.036432527,-0.012199901,-0.12145871,0.06648953,0.016840493,0.057090957,0.00045031664,0.016421625,0.0137519725,0.03183086,-0.06695069,0.029522285,0.03603958,0.05621683,-0.0072717634,-0.04457664,-0.0008086725,-0.00012806396,-0.049122073,-0.015480663,-0.01734949,-0.013139172,-0.043389365,-0.0067139,-0.06597017,0.0016092244,-0.049249217,-0.059257593,0.06142748,-0.055848647,-0.024364624,-0.032452866,0.020152437,0.019314975,0.06957095,-0.05001413,0.030321188,-0.06448747,-0.054055355,0.062326398,-0.044177383,-0.026817378,-0.048830863,-0.0056832256,-0.14575359,0.036794905,0.036974996,0.032683354,0.064410776,-0.0013796978,-0.029932505,-0.010804995,-0.1327409,-0.07467322,-0.025160806,0.041019358,0.009497328,0.03762473,-0.024179436,0.024167737,-0.0006758716,0.08355542,0.06628247,0.02630191,0.013103588,-0.01556807,-0.019528084,0.03954325,0.026038513,-0.0024003226,0.05832272,-0.021030642,-0.023414493,0.0074855317,0.10349361,-0.12443278,0.0228572,-0.0024158035,0.013787684,-0.026230054,-0.0058793267,0.09015108,-0.077705614,0.0009330861,0.011408207,0.04145943,-0.036975976,-0.033174604,0.021146169,-0.0053516594,-0.041998576,-0.0021270248,-0.03528951,-0.025230564,-0.032658577,-0.05481758,0.089183,-0.037763465,-0.0035602048,-0.15898529,6.4637023e-34,0.045631886,0.0112510035,0.009793617,0.031133318,-0.097646944,0.040547322,-0.10289989,0.010215364,-0.08247551,-0.099067144,-0.10907291,-0.028896535,-0.031613387,0.045493282,0.03065771,0.006763714,0.06381186,0.026840877,-0.0052668285,-0.041565552,-0.04815106,0.037358563,-0.06822357,-0.02691732,0.09387176,0.03569866,0.043881018,-0.042967897,0.049690787,-0.006910378,-0.06118246,-0.1271758,-0.034656517,0.09309344,0.026349558,0.05637227,-0.02763062,-0.008163458,-0.057735678,0.108884186,0.0010133524,0.053738073,0.057695914,-0.009866279,0.009110319,-0.063883945,0.011217043,0.0023558692,0.09632315,0.028855054,0.0041323313,0.016543597,0.06333167,0.004868738,-0.066276215,0.070901744,-0.07630595,0.03971854,0.023036785,0.034189835,0.03690693,0.06424128,-0.031062506,-0.0534305,0.046962753,0.075440854,-0.07500254,-0.050007906,0.008798418,0.08516461,-0.06932728,0.048342403,0.089131676,0.0448907,0.05988287,0.0019829422,-0.037666213,-0.0071059633,0.04208219,-0.058096714,-0.02899878,0.0138666425,0.03223785,0.044278335,-0.050896406,-0.029325781,-0.01173082,0.098008834,0.0060032755,0.06776455,0.1249302,-0.029552588,0.0036561086,-0.009556303,-0.014633779,-2.3307313e-33,-0.051010944,-0.07892284,-0.01832979,-0.079407945,-0.025402686,0.0723657,0.028917097,-0.012210065,-0.04132137,-0.022322819,0.09940316,0.027383976,0.086646,-0.09410485,-0.0101084,0.085162535,0.014443922,0.13218224,-0.034022152,-0.01189332,-0.08820484,0.06670858,0.053384624,0.065428,-0.0397886,0.060157914,0.014751809,0.004301626,0.03746502,0.0140086515,-0.013874645,0.052423473,-0.06909892,-0.05285531,0.021205286,0.08573038,-0.059853543,-0.014814519,-0.00727453,0.043606155,-0.0741642,0.030234495,-0.028100388,0.03816267,0.07459754,0.08673678,-0.01277379,0.024579937,-0.010096867,-0.020011595,0.01923725,0.029379562,0.056523446,-0.040532906,0.045612227,-0.01337294,0.009774823,-0.045430683,0.008925479,-0.023702152,0.005291861,-0.0057570874,-0.0037258214,0.01208995,-0.0005966768,0.08257732,-0.0409856,0.065538,-0.041388527,-0.024947047,0.103710234,0.06404181,-0.03482146,0.0178255,-0.010280791,-0.05021008,0.014593623,-0.06792695,-0.0025915783,0.02286149,-0.017785095,3.2405937e-05,0.049855348,-0.056580197,-0.02772037,-0.04880849,-0.0058741244,0.012492892,0.055217884,-0.0003760784,0.025070908,0.00069188356,-0.10575491,0.009183237,0.050833203,-3.705865e-08,0.045006845,-0.0930296,0.027826997,-0.080574945,-0.012465293,0.02401114,0.007906599,-0.0016561804,0.017627737,-0.03904894,-0.05913016,0.050644014,0.006533255,-0.00088514015,0.01740081,0.052024025,-0.008770306,0.033309896,-0.00278763,0.03450409,-0.07711176,0.06734449,-0.08234249,-0.035327103,-0.0043070973,-0.04836036,-0.0074533713,0.040831853,0.0034903965,-0.033935703,0.09016425,0.021399545,-0.034253526,-0.0062150094,-0.0151431225,-0.0023041535,0.07186411,0.023690436,0.02345906,0.09813952,0.040360462,-0.043029435,-0.011212233,0.070516445,0.05575708,-0.006802436,0.059268065,-0.024070386,0.0060472563,-0.025769165,0.017139187,0.004131823,0.019530687,-0.06092637,-0.06513114,-0.12302787,-0.034870252,-0.10894577,0.02216178,-0.08961912,-0.021236284,-0.032964643,0.13463956,-0.0071348 +2.1.1.280,"The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine. The enzyme from broccoli (Brassica oleracea var. italica) also has the activity of EC 2.1.1.10, homocysteine S-methyltransferase [4].",384,1.0,-0.01604625,-0.01697355,-0.119362935,0.010510778,0.08046419,0.102871835,-0.1414379,0.07331765,0.0396191,-0.032139223,0.08105406,-0.060957283,-0.038727928,-0.012694718,-0.017896028,0.049640957,-0.029455658,-0.004275281,-0.0025439032,-0.046631683,-0.018631486,-0.010370397,-0.058553882,0.032105904,0.07165745,-0.02880458,-0.008115552,0.0018680594,-0.04888958,-0.029159032,-0.05139797,-0.06703344,0.08341677,-0.00864551,0.0051927813,0.085373536,0.007597676,-0.05018924,0.088359684,0.019492758,0.056554534,-0.043198958,0.008412712,-0.074829735,0.0008447633,-0.007040946,-0.026257863,0.009762589,0.013608821,-0.03431886,-0.028449442,-0.044745743,-0.008482864,-0.0009177452,0.013331495,0.05961006,0.009160887,-0.009037837,0.020607892,0.022343814,0.030647827,-0.06197487,-0.030693233,-0.023084475,-0.026434282,-0.07176029,0.031594854,-0.12379729,0.021798735,-0.04548554,-0.03834895,-0.07958679,-0.062396705,0.084244974,0.036011513,0.03908615,-0.05363129,-0.022844767,0.093290806,-0.04642366,-0.005095237,-0.0067913146,-0.060260605,0.034070402,0.029189365,0.041230083,-0.024741003,0.009457558,0.039714266,0.040803563,0.05015348,-0.011957897,-0.025116613,-0.08094667,-0.07643344,0.003622616,0.06643191,0.07660114,0.011909165,-0.012778751,0.02516344,0.010813979,-0.12357812,-0.11216899,-0.07009843,0.013722699,0.07251141,0.009826206,0.0002869021,-0.039701484,0.029935295,-0.021861682,0.010220353,-0.06251406,-0.07878452,0.055569097,0.05022463,-0.07282274,-0.046443556,0.058823343,-0.0056459336,-0.045883365,0.09719252,0.05813766,-0.027269205,0.004305227,-0.06725264,7.5791752e-34,0.051874317,0.043905634,0.031326845,-0.052936856,-0.007464738,-0.020853937,-0.054877073,0.014223398,0.021662816,-0.101870276,-0.1185759,-0.02776408,-0.011325232,-0.018808346,-0.044730302,0.04487012,0.004433756,-0.058873836,0.03805761,-0.0013035419,0.020361638,-0.029238222,-0.030565998,0.028102748,0.038067926,-0.023199696,0.051003296,-0.02295983,0.041475236,0.028804801,-0.07461433,-0.031811446,-0.042421993,0.021099748,0.049820494,0.031784058,-0.023727443,-0.026110442,0.011470299,0.0996031,0.026138458,0.05337245,0.033224825,-0.000403801,-0.013577598,0.01988901,-0.030099986,0.027220696,0.012720462,0.03925588,0.01342429,-0.07809868,0.05648377,0.013008629,-0.04437455,0.042189833,0.033343717,-0.011566903,0.034267984,0.066363655,-0.03919319,0.060685866,0.023248244,0.02831248,-0.008877612,-0.022608984,-0.12625508,-0.040215787,-0.033190824,0.0048462506,0.026174054,-0.04903986,0.03315357,-0.0017231854,0.02296962,-0.045259964,-0.06593423,0.049153913,0.06620343,-0.003260968,0.045954365,0.027123272,0.036441837,-0.06134723,-0.084191814,-0.022506312,-0.07470109,-0.060141627,-0.020887202,0.028400412,0.045408756,-0.035504185,0.030138142,-0.021969913,0.034857854,-2.2234057e-33,-0.003997311,-0.06050122,0.032023415,-0.07685624,0.0039552217,0.08339994,-0.0011893054,-0.049286854,0.07543476,0.038979188,0.1300021,-0.032535207,0.007268695,-0.061879702,0.061826285,0.048293684,-0.003399898,0.10302441,0.0049715824,0.0013871243,-0.058939762,-0.019672278,-0.0081620095,0.04818734,0.071621396,-0.0060172724,-0.0626633,0.09147088,0.08933839,0.04919951,-0.024788257,-0.015275822,-0.05151679,0.025425345,0.015805323,0.05836083,0.004758315,0.010650167,0.068730004,0.05747578,-0.013743558,-0.015223775,0.06575325,0.11856912,0.055977,0.07053447,-0.08872195,0.03580768,-0.03468713,-0.07234258,0.06533178,-0.0357665,-0.011617594,0.036400087,0.011010702,0.055592734,0.044957343,0.01573804,-0.0671048,-0.052664347,-0.007569995,-0.048969522,-0.05216169,0.047585074,-0.0059287576,0.05187052,-0.05279684,-0.028383408,-0.025541425,0.016412724,0.04436904,-0.032136787,0.025671922,0.029921934,-0.027106127,-0.032787714,-0.064019345,0.017152693,0.008002752,-0.01744819,0.0030700006,-0.02010195,0.010881881,-0.10433382,-0.009985361,-0.040404674,0.027619291,0.07909393,-0.04667736,0.098585896,-0.11063018,0.03899917,-0.065413855,0.058271434,0.09375539,-3.7539543e-08,0.035450015,-0.1485213,0.008784548,-0.054893978,-0.024251444,0.014586353,-0.030872535,-0.0041656215,0.11772087,-0.058577314,-0.056888588,0.061946303,0.011920065,0.043698393,0.0022776509,0.0008091339,0.051668644,0.043830864,-0.0060234875,0.05021985,-0.065475985,-0.014882167,-0.044634666,-0.07161777,-0.007852708,-0.055488564,0.012580149,0.12572294,0.005864551,-0.042347565,0.03264326,0.019841924,-0.10458656,0.009165491,-0.069968164,0.038431074,-0.058403075,-0.0358683,0.01508978,0.080779664,0.04208169,0.027680924,-0.13417354,0.036038682,0.028876677,-0.0142695,0.032048658,0.065509535,0.0057398486,-0.0051790806,-0.015275339,-0.03639205,-0.009353559,-0.047300275,-0.010539646,-0.007146681,0.07589499,-0.040375195,0.02689359,-0.04842387,-0.006804202,0.034239776,0.20004658,0.02889774 +2.1.1.281,"The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.",384,1.0,-0.006182427,0.009287991,-0.16125636,-0.052842565,0.0072632646,0.07338362,-0.05119266,0.06016336,0.06618187,0.044382527,0.03056967,-0.028826263,0.051410496,0.072387345,-0.009137747,-0.017685743,-0.09409557,0.014205945,0.051129147,-0.054013394,0.02795716,0.11899295,0.046051722,0.00088163326,0.047386386,0.002611084,0.031638455,-0.048653226,-0.08586844,-0.039931856,0.071012795,-0.10405289,0.043757237,-0.06505777,0.12797695,0.009809528,-0.027177922,-0.06558817,0.12476554,0.024944616,-0.080020696,-0.032825265,-0.044955887,0.019521195,-0.058950163,0.04481357,0.014158488,0.095549,0.082994334,0.020818759,-0.07737291,-0.069082245,-0.0060774065,0.042202037,0.046118736,0.09934982,-0.033259436,0.0038665337,0.038865868,-0.02878819,0.032865334,-0.017052272,0.12840644,-0.012698753,-0.039887223,-0.0661297,-0.024713147,-0.09198224,0.11560887,-0.0028247107,-0.06033817,-0.06479321,0.006725619,0.01594978,0.024641829,-0.01974518,0.020515783,-0.057045076,0.004735752,-0.04637343,0.034259446,-0.03608484,0.048959177,0.06201162,0.018519565,0.011917241,0.0067771585,-0.0098178545,0.07011223,-0.02204342,0.046419583,-0.030790946,-0.023958556,-0.08459256,0.008503632,-0.048164148,-0.08102366,0.010536087,-0.003131809,0.037558116,0.0022834435,0.0026167708,0.035003476,-0.013554327,-0.007188909,-0.0038200687,0.0070381314,0.028571468,-0.038771193,-0.0355826,0.026969507,0.014009952,-0.00174992,-0.07788522,-0.028957887,0.073438264,0.11252773,-0.057121355,-0.07272427,-0.04025019,0.0017186416,0.01364993,0.022134604,0.0067712422,-0.047285933,-0.0071118004,-0.1119074,2.4540314e-33,-0.02065489,0.05478194,0.0282327,-0.045822285,0.0797735,-0.019807203,-0.02993425,-0.016756374,0.031157902,-0.033057973,-0.08635266,-0.101439565,0.014670442,0.049432438,-0.017472114,0.018564895,-0.039368056,0.075895056,-0.0019404881,0.0016174258,-0.002197047,0.055156857,0.02856434,0.023971373,0.046086375,0.03606453,0.014070023,0.013504267,0.13381079,-0.031137189,0.02691615,-0.04429024,-0.0746687,-0.046127487,0.011822766,-0.06137266,-0.0670025,-0.0821233,0.08464998,0.060484737,-0.022999194,-0.012281502,-0.031514093,-0.012509119,0.0322724,0.011955253,-0.0027602185,0.0796712,-0.017766416,0.03651866,0.07569147,-0.026506001,0.020801235,0.025163176,-0.02995767,0.0070004403,-0.034626644,0.025228225,0.09512632,0.035913937,-0.0056446823,-0.0010425219,0.03036766,-0.010663454,0.034163542,-0.0014292541,-0.0142032355,0.008837343,0.03165962,-0.007911544,-0.050738327,-0.026893418,0.031228604,0.052998044,0.032861482,-0.06013188,-0.10745243,-0.020789612,0.08313782,-0.012396462,0.03896606,0.024262596,-0.012072629,-0.041115247,-0.03975744,-0.010015719,-0.06878909,-0.109577164,-0.014206477,0.04422325,-0.05023927,-0.06499077,-0.11371322,0.068822324,0.013089661,-4.0192055e-33,0.0911037,-0.053998366,0.036957435,-0.05711707,-0.051873084,0.03202014,0.010199867,-0.04773527,0.01275799,-0.04229654,0.0915026,-0.032387137,-0.004301083,-0.07016983,0.03440096,-0.029418837,0.00026571288,0.102221705,-0.05362695,0.039207462,0.02675649,0.034087438,-0.020667112,-0.008704794,0.006421889,-0.008567714,-0.050222415,0.06686838,0.067235194,0.108009964,-0.010529223,-0.018305937,-0.04093847,-0.028669376,0.0036390165,0.048450377,-0.057314835,0.028529968,0.037924323,-0.06321703,0.032473605,-0.007472215,0.009380502,0.013166384,-0.020183334,0.07730719,-0.036025055,0.05442836,-0.049375627,-0.10512907,-0.017728304,-0.030437741,0.008169378,-0.036634117,0.010011283,0.026600666,-0.05178667,-0.0240979,0.024901222,-0.020357713,-0.041952457,-0.07609286,0.06879159,0.00444904,0.043581873,0.029973032,-0.027190292,0.02486732,0.15778872,-0.035963144,0.018886695,0.008829178,0.034212276,0.055828456,-0.004244926,-0.0013996216,-0.06797535,-0.031360842,0.067234814,-0.034717605,-0.024768526,-0.037558127,0.024328914,-0.0010568158,0.028634299,-0.0135337785,0.045784075,0.03421991,-0.0029949232,0.04403195,-0.006159851,0.0325685,-0.016497314,0.0848527,0.060001675,-3.5656228e-08,0.09267983,-0.009547491,0.11221839,-0.046054527,0.045605294,-0.028516503,-0.0026003,-0.015070094,-0.012394626,-0.022200797,-0.03580296,0.017696735,0.00963049,-0.022188507,-0.077395655,0.0081268875,-0.097690634,0.063324206,-0.0046957363,-0.05224089,-0.09142902,0.02957022,-0.04002678,0.029595146,0.06684918,0.020088825,0.03010488,-0.001429667,-0.036335256,0.002311749,0.067583695,0.0015506352,-0.075237215,-0.019295404,-0.027466562,-0.03538291,-0.09228544,-0.0062935264,0.017175037,-0.049767587,0.0064955917,0.031715687,0.0036456233,0.00094229385,-0.07943607,0.044604484,-0.061522704,-0.00057966897,-0.11877886,-0.01828159,0.049371764,0.025511734,-0.043981764,0.028633112,-0.1320409,0.010332157,-0.032482885,-0.07326962,-0.06808548,-0.0486388,-0.01098849,-0.029994704,0.1705095,-0.043120846 +2.1.1.282,"The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs. These modifications are important for translational reading-frame maintenance. The enzyme is found in all eukaryotes and in some archaea, but not in bacteria. The eukaryotic enzyme is involved in the biosynthesis of wybutosine.",384,1.0,-0.05309096,-0.019122565,-0.16337842,-0.052095953,0.028746806,-0.013133267,-0.05190116,0.016237792,-0.01249309,0.014263042,0.045549933,-0.03706657,-0.058513895,0.0299903,-0.061982296,0.04047137,-0.14147681,0.0033424888,0.01066025,-0.05997365,0.08067053,0.10561112,-0.018351726,-0.00543588,0.0025123616,0.015031549,0.023294631,-0.03862719,0.01517337,-0.021244314,-0.035862308,-0.006897183,0.046387177,-0.04254034,0.04920197,0.1003519,-0.09931478,-0.06702693,0.11953183,-0.017925642,0.047777876,0.018171689,-0.027408557,0.02286493,-0.035604328,0.029642656,0.051680256,0.009085091,-0.027025588,0.03277804,-0.04404274,-0.05665083,-0.038640223,0.051460546,0.0043691485,0.032811858,-0.027806232,0.0077476185,0.032385726,-0.04175151,0.061902706,0.027384564,0.034289777,-0.008151788,0.043532804,-0.07499953,0.057192218,-0.03686882,-0.022218425,-0.07341935,-0.034232106,-0.03323552,-0.03728099,0.062719874,-0.044917803,0.031288967,0.026052611,-0.013258629,-0.0028482543,-0.02590175,0.04175246,-0.040064994,0.09052741,0.06387849,0.03686275,-0.042592324,-0.017420366,0.006501465,0.023983724,0.006727482,0.06804008,-0.06690284,0.03865978,-0.02069433,-0.058310594,0.045475926,0.073632404,0.073147625,0.05532,-0.05888906,0.010647591,0.0044375537,0.012066211,-0.018594997,-0.03137531,0.011199309,0.011100324,0.08653518,-0.002765224,-0.011802302,-0.063576184,0.04770386,0.075792395,0.015358973,-0.013624006,0.080153264,0.053324673,0.001764093,-0.016204106,-0.013407416,0.022788147,0.017055148,0.118666716,0.05528471,-0.049548175,0.026221657,-0.08500715,2.2754318e-33,0.06320557,0.03353878,-0.0378339,-0.028609702,0.030270716,-0.042542987,-0.023215082,-0.056191307,-0.05307874,-0.041708626,-0.103248365,-0.051767487,0.093338296,0.020409247,-0.070206486,-0.023544576,-0.0084245205,0.009531808,0.00542755,0.096038185,-0.025722932,0.07891907,-0.069177404,0.029526092,-0.019963602,0.063226245,-0.0005780455,0.014953663,-0.016692322,0.004319352,-0.055403057,-0.11397019,-0.07998379,-0.007153189,0.13136587,-0.0057616616,-0.03557797,-0.039488494,-0.067637235,-0.018848335,0.05029548,-0.032937326,-0.021952791,-0.032151487,0.05482358,0.03269628,-0.057919115,0.10566248,-0.028713891,0.024943506,-0.010758538,0.026908679,0.061672438,0.00047249973,-0.05172116,0.057925772,0.022060372,-0.045689605,0.083472304,0.03721041,-0.028982837,0.013915104,-0.0199607,0.08936457,-0.047428623,0.01333123,-0.085267484,-0.071826085,-0.027220022,0.086908996,-0.079151705,-0.08405462,0.07832558,0.062388446,0.008058612,-0.024869503,-0.036596317,-0.0686822,-0.054122455,-0.02874624,0.026962833,0.012480573,0.04564842,-0.06782831,-0.004229562,-0.03199463,-0.055248916,-0.07758257,-0.05430524,0.020697769,0.06020573,-0.036623903,-0.06873544,0.01140301,0.010893197,-3.8403782e-33,0.07321755,-0.06776549,0.032885518,-0.07749808,-0.08535425,0.04851598,-0.008907984,-0.09856762,0.009093191,-0.04972561,0.075396374,-0.038991462,-0.08433019,-0.01964172,0.013810164,0.034131248,0.06534183,0.02146705,0.0012110181,-0.0484782,0.063093275,0.024669245,-0.025298767,-0.03359229,0.014304463,0.0037963118,-0.07270986,0.07656973,0.027366009,0.07816329,-0.12619516,-0.039496224,0.003931324,0.007727611,-0.025006758,0.078463815,-0.028555661,-0.014040942,0.042927597,0.012792481,0.045606278,0.03873462,-0.0038765192,0.07090605,0.017879581,0.10190041,-0.08334,0.007564559,-0.06423833,-0.047552396,0.06550497,0.029512946,0.06849837,0.017994458,0.044940922,0.06235626,-0.025466302,0.02136719,0.002466577,-0.01760828,-0.0030471657,-0.08368058,0.028873187,0.0020785541,0.004805441,0.013687997,-0.0565804,0.07687346,0.008661482,-0.050003316,0.04434023,0.011287928,0.009165672,0.094893016,-0.028112696,-0.02680729,-0.05337532,-0.099565014,-0.018923417,-0.05038519,-0.025968341,0.038903743,0.045023814,-0.057374943,-0.017002575,-0.08097173,0.036675766,0.098457545,-0.01025539,0.009984231,-0.02089344,0.0023336178,-0.019958388,0.05684846,0.09459879,-3.793263e-08,-0.04941293,-0.03386534,0.013536529,-0.04470768,0.021955855,0.041600265,0.00989771,0.060788948,0.038741607,-0.028632557,-0.03135082,0.035874687,-0.021243291,0.039549988,0.05152812,0.09523953,-0.060521234,0.0023841064,-0.014411504,0.009104593,0.008762052,0.029896168,-0.07458058,0.06565235,-0.018603984,-0.0022734364,0.04387686,0.051803883,-0.037223108,-0.043243077,-0.04014025,0.023075048,0.0012117891,-0.054453705,-0.08330943,0.04185694,-0.052375317,-0.058014542,-0.05492162,0.04707319,-0.041666504,0.010998544,-0.08308683,0.04151741,0.026399657,0.009730242,-0.042783268,0.07141631,-0.022629486,-0.06263275,0.058752175,0.0007860006,0.013673845,-0.04946666,-0.08832994,0.01478336,-0.0053097145,-0.039523248,-0.047325056,-0.00046834038,-0.039502345,0.07518627,0.1861555,-0.08674759 +2.1.1.283,The enzyme is involved in biosynthesis of the seco-anthraquinone (+)-geodin. ,384,1.0,-0.060865756,-0.03888896,-0.09949692,-0.027526846,0.008052268,0.013122429,0.0030471038,0.036882978,0.09251009,-0.02226443,0.02137975,-0.014184975,-0.07663593,0.0245112,-0.09448979,-0.033430185,-0.07277151,0.025774278,-0.01149785,-0.084146895,-0.016651899,-0.0224972,0.0053133667,0.070395425,0.019159533,-0.006400677,0.020925615,-0.035494436,-0.035659626,0.08065092,0.00528147,-0.03788385,0.0072320574,-0.052751064,0.0070301895,0.10533231,-0.002128802,0.006804442,0.104883574,0.09684125,0.0064274506,-0.0766858,0.010922265,-0.0019082633,0.029097913,0.011810373,-0.03972634,0.030442005,0.07589911,0.020008478,-0.07841459,-0.012210885,-0.11085898,0.01470414,-0.0018481564,-0.026751006,-0.043351315,-0.052751612,-0.03890391,0.03675504,0.0171787,-0.021106312,-0.02793718,0.09979577,0.018362012,-0.05020715,0.07251871,0.016386962,0.04716275,0.0080823,-0.026904503,-0.054817278,-0.048986454,-0.030899001,-0.04044216,0.027388686,-0.050997645,0.013241328,0.037540004,-0.07955682,0.08003771,0.055382125,0.0725043,0.1225476,0.029201899,0.04855719,0.074121125,0.042416047,0.06892348,0.035765965,0.04798731,-0.013640218,-0.048141405,0.013215428,-0.044134364,-0.003294044,0.03966122,0.027650138,-0.010217592,-0.027142532,-0.052661993,0.049898677,-0.07871208,-0.07565844,0.020846996,-0.01115188,-0.026751397,0.07669596,0.028560176,-0.017256219,-0.027679596,0.031262487,0.040863216,0.024638303,-0.024542185,0.10195174,-0.0008880595,-0.012846323,-0.0429141,0.07752693,-0.018049277,0.0025166762,-0.06395291,0.0898216,-0.05212599,0.031693,-0.023289306,-2.1167178e-33,0.051527414,0.057997458,0.024725003,-0.06110366,-0.027192812,0.083893836,-0.0968556,-0.017133154,-0.14231907,0.027751591,-0.0029736697,-0.11390905,0.02786802,0.044214144,-0.03747405,0.008643429,-0.017110981,-0.07209954,0.03081583,-0.031176131,0.025560072,0.06260371,-0.019730233,0.029428164,0.02020627,0.07144874,-0.05267021,0.09346377,-0.028984163,0.011612825,-0.021032367,-0.098675154,-0.06716745,0.017708195,0.049536306,-0.058791503,0.00031243043,-0.075066485,-0.016051073,0.057064,-0.009325301,0.077024564,-0.0027021752,0.0064718393,0.041394364,-0.061555035,-0.09186079,0.11579583,0.07858627,0.03987481,-0.04154613,0.04525358,0.09469514,-0.03634515,-0.09077677,-0.023554197,-0.0836048,0.025271632,-0.0050143762,0.044664044,0.0021184017,0.07019646,-0.015964417,0.008148369,0.012917022,-0.010311885,-0.055146202,0.01815662,0.049139403,0.08256677,-0.04415018,-0.01023576,-0.008684152,0.07884876,0.06604067,-0.060926896,-0.043449756,-0.03330202,-0.02420014,0.019254671,-0.08898923,-0.061263446,0.03451401,0.080191284,-0.07391749,0.022199538,-0.00753372,0.017989479,0.020738933,-0.002756715,0.010173328,-0.052987438,-0.06277703,0.00013802189,-0.02329011,-3.0830276e-34,0.040183984,-0.08284233,-0.03329539,-0.08652889,-0.11893616,0.052996494,-0.023444554,-0.039369266,0.02999758,0.049749218,0.040882375,0.04905621,0.055409133,-0.0340965,-0.046321906,-0.0027096933,-0.041021544,0.05696182,0.023250187,0.03447968,0.026755812,0.03828178,-0.023819853,-0.00048166863,0.07817096,0.016273893,-0.00635109,0.0744046,-0.019640815,0.068522066,0.013609299,-0.019277247,-0.11169379,-0.047990445,-0.0183283,0.047379605,0.009920173,0.04245402,0.046686687,0.017089324,0.046412338,0.019818308,0.04929292,0.05783811,0.09319498,0.104360335,-0.05242703,0.10245827,-0.07305905,-0.024311919,-0.0128962565,0.004749711,0.025842665,0.017204085,0.044287033,-0.005869818,7.079602e-05,-0.047980238,-0.045261644,-0.057428963,0.016610995,-0.04314704,0.033091776,-0.033308532,0.026105283,0.06870446,-0.016649637,0.052611478,0.06071217,-0.054662883,0.11815164,0.017879868,-0.018172732,-0.002956215,-0.07477801,-0.013605376,-0.04865566,-0.06323331,0.001299632,0.008269288,0.028982336,0.042056646,0.025056966,-0.04363496,-0.02164471,0.031141682,0.026821401,0.13042872,-0.023721335,0.0247854,-0.032518987,-0.012811816,-0.06917904,0.012486879,0.04443037,-2.419358e-08,0.07300999,-0.053041812,0.047827605,-0.09266537,-0.019693445,-0.0016957405,0.035891864,0.012213606,-0.03427101,-0.016265895,0.017795548,0.052453984,0.009875609,0.030442355,-0.0162785,0.036041528,0.036399964,0.026776075,-0.032839485,-0.015472856,-0.03691196,-0.02159015,-0.06061311,0.008969624,-0.023658793,-0.098346576,0.060115647,-0.010479525,-0.04186998,-0.09732309,0.006763529,-0.048141725,0.009450067,-0.011178255,-0.08515194,0.09531238,-0.09587545,-0.047902085,0.050301824,-0.061934903,-0.038102265,-0.07629525,-0.026679918,0.0122202765,0.03703545,-0.015020516,0.05333093,-0.035063684,0.007889081,0.015176092,0.057841778,-0.038166393,0.031558514,-0.058589675,-0.053152867,0.019619005,-0.034841027,-0.062399995,0.013760496,-0.058731183,-0.06052423,-0.03050731,0.16820459,-0.09267134 +2.1.1.284,The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. 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+2.1.1.285,The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. ,384,1.0,-0.07655132,-0.04117458,-0.10220992,-0.012007542,0.020381158,0.058537118,-0.09953576,0.05696685,0.11252188,0.012584906,-0.033604488,0.012229488,-0.006431249,0.049205065,-0.060948085,0.030242985,-0.075126246,0.007172689,-0.025435759,-0.032301284,0.034022234,0.054225773,0.0044703474,0.0014893318,0.10087256,-0.024448132,0.055853903,0.055355694,-1.2574209e-05,0.026902234,0.051284656,-0.01965188,0.01576081,-0.06740573,0.07080248,0.04772036,-0.04645691,-0.042588446,0.15334785,-0.04431983,-0.049602333,-0.0055633388,-0.068177044,-0.052047465,0.0062341886,-0.044913225,-0.015717681,0.071568735,0.084321305,0.038733594,-0.019784907,-0.0015273653,-0.085708834,-0.003726457,0.12458795,0.07020782,-0.042341556,-0.13252768,-0.019376084,3.6445854e-05,0.030753518,-0.047806036,-0.009728591,0.05662213,-0.04534617,-0.0072641056,0.016373215,-0.035226,0.035957817,-0.04620654,-0.08996099,-0.0808878,0.058877256,0.009151931,-0.0065695704,-0.05531537,0.0042867726,0.005006763,-0.007936771,-0.029463306,0.035940245,0.014464538,-0.007598431,0.0986202,0.021925543,0.0027442472,0.13428482,-0.008460959,0.048281014,0.033505987,0.0106276525,-0.016975107,0.032272615,-0.106488846,-0.042332076,-0.036257375,-0.054633215,0.031134691,-0.0044316933,-0.03001755,0.02230845,0.034235932,0.030526007,-0.060359556,-0.026091773,-0.002602465,0.007674471,0.12050736,0.02091615,0.01117796,-0.031531878,0.00079802837,-0.04307931,0.02458049,-0.06720662,0.08308798,0.057807628,-0.057219386,-0.0873136,0.06314733,0.0018068727,-0.02867392,0.03128706,0.09588978,-0.029203646,0.0007868426,-0.019701097,-2.0418903e-33,0.021121707,0.023759749,-0.014613744,-0.028260803,0.05810861,-0.021353032,-0.066623226,-0.037433464,-0.012778122,-0.040126517,-0.057720073,-0.095500425,-0.02389444,0.07519145,0.010198321,-0.025424395,-0.04494758,-0.009886337,-0.03768263,0.071110874,-0.0042467485,0.07319223,-0.011222893,0.027577566,0.0050111855,0.065642186,-0.069366954,0.077992275,0.060605295,-0.023220187,0.0028927953,-0.0061653797,-0.088674776,-0.027498592,0.06816687,-0.014932586,0.030280784,-0.027972667,0.071637474,0.07297879,0.017009832,-0.0036625972,-0.044130515,-0.007969695,0.061529607,-0.016066981,-0.046523232,0.034025192,0.030731156,0.030432684,0.049786072,-0.029576601,0.08109053,-0.017072208,0.014638106,0.0075787697,-0.036276605,0.020256203,0.010470258,0.051334586,-0.030154567,-0.0076575214,0.014424165,0.09264447,-0.005875104,-0.023314727,0.015264455,-0.030781908,0.023831762,0.067355335,-0.05012931,0.046258308,0.020532776,0.056154184,-0.010439173,-0.030395914,-0.048140675,-0.020549977,0.044193204,-0.011680458,-0.0315099,0.01907179,-0.008944473,-0.016616171,-0.060234398,0.00020084104,-0.01673024,-0.06347057,-0.038553793,0.008218044,0.028235827,-0.07305522,-0.10545454,0.0035167008,-0.01801879,-2.1014845e-33,0.122206554,-0.122517854,0.039696194,-0.072793245,-0.104677305,0.11189836,0.004673484,-0.047583595,0.015275402,-0.0015916044,0.021422382,0.018392716,-0.005286055,-0.024392558,-0.016514894,-0.055437572,0.028265415,0.03767553,-0.057635963,0.0059583876,0.0071069873,0.03303933,0.05711424,-0.0908223,0.043696534,0.037801877,0.026680652,0.089219704,-0.041151848,0.047339983,-0.016276676,-0.029799603,-0.07753623,-0.03866596,0.0025727006,0.102737,0.017757736,0.008806569,-0.050670207,-0.060979743,0.018531393,0.044199493,-0.03871916,0.039714493,-0.020649899,-0.020126697,-0.04091421,0.011732252,-0.037038557,-0.09768241,0.069681585,0.031091426,0.07211019,0.0186154,-0.017881773,-0.016846156,0.054149855,-0.04565582,0.06905095,0.031302575,-0.06098865,-0.019078124,0.040312454,-0.00910668,0.021604508,0.048722748,-0.0031360164,0.04177566,0.053172518,-0.042041585,0.04661393,-0.026560752,0.032184545,0.059433937,-0.049528766,0.02387989,-0.044470213,-0.054918077,0.022630822,-0.009020303,-0.05367924,-0.022985484,-0.04722689,0.008625997,-0.12853797,-0.04395131,0.08048683,0.075316235,0.034626625,0.013458776,0.0069107395,0.02135424,-0.061976727,-0.011133355,0.0055770143,-2.3821265e-08,0.07028109,-0.04675025,0.09325026,-0.052195936,0.06742576,0.026094928,-0.04068781,-0.06301726,0.024411911,0.005102012,-0.016733963,0.10287798,-0.06314233,-0.0006459784,-0.060843598,0.03158349,-0.049680565,0.033549227,0.010717154,-0.038214374,-0.10943925,0.05767886,-0.10748864,-0.04270146,0.05374207,-0.08673102,-0.027469682,0.022747563,-0.01953562,0.03597574,-0.021475442,-0.014941369,-0.012425929,-0.08996703,-0.07751088,0.012225144,-0.033108804,-0.0719192,0.028626611,-0.034291934,0.043510783,0.024513142,-0.0102829635,-0.017282164,-0.082205825,0.05052991,0.011741706,-0.016677182,-0.055722933,3.4042405e-05,0.024004465,0.0007549345,-0.008314228,-0.07415676,-0.14292122,-0.008019259,-0.004090595,-0.12212001,-0.027581267,-0.02203659,-0.08481837,0.032021027,0.17396542,0.011105314 +2.1.1.286,In the yeast Saccharomyces cerevisiae this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin. 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+2.1.1.287,"The enzyme is found in eukaryotes. The adenine position refers to rRNA in the yeast Saccharomyces cerevisiae, in which the enzyme is important for ribosome biogenesis.",384,1.0,0.024490213,-0.034506023,-0.08607917,-0.0805104,-0.016485495,0.03354286,-0.057187617,-0.01992957,0.09107742,0.042761795,0.026590116,-0.0139754275,-0.019550648,0.056489967,-0.07089721,0.027516542,-0.08956891,-0.036362022,0.055530094,-0.06672367,0.04916036,0.13668603,0.07062047,0.0400602,-0.018759111,-0.027353462,0.06910668,0.017949453,-0.016229564,-0.07120663,-8.621432e-05,-0.03107004,0.080815874,0.032495245,0.0053496463,0.095394224,-0.0525952,-0.047489893,0.060103297,0.02876879,0.014484266,0.021687126,-0.04157419,0.027974457,-0.0048975335,0.0695161,0.06322224,0.03124533,0.053535294,-0.00017285516,0.028976325,-0.115284815,-0.0523808,-0.03797544,0.05712654,0.091231905,-0.0428447,-0.071190916,0.033420246,0.016691662,0.09804279,-0.041129768,0.007038734,0.005472544,0.07406759,-0.08785811,0.08689556,-0.0040259715,-0.040887434,-0.08673256,-0.015332952,-0.052907344,-0.022676243,0.069431946,-0.04185545,0.00399908,0.025011167,-0.046761096,-0.015527802,-0.015502265,0.027414557,0.01069943,0.044616614,0.021457689,0.01493375,0.0098403655,0.053235203,-0.0056694234,0.044609923,-0.010951564,0.021912416,-0.0037554598,0.00680827,-0.017512884,-0.0075867986,-0.040574677,0.047050215,0.0747015,0.048898906,-0.074432954,0.057390835,0.031990327,-0.019249802,0.041289482,-0.028333426,0.018917648,-0.05716771,0.061073355,-0.030613817,0.021586653,-0.032470774,0.07648101,-0.0312688,0.017797377,0.039028265,0.041294985,0.026562113,-0.024428912,-0.0037923246,-0.012883679,-0.12406474,-0.0006362152,0.029617187,0.085501164,-0.043293055,0.06368744,-0.102427214,5.5291085e-34,0.031066136,-0.018108139,0.025732104,-0.028141625,-0.008348037,-0.0012677973,-0.02316167,0.04823959,-0.013500837,-0.07127277,-0.08918076,-0.03650887,0.058902696,-0.015164476,-0.026336994,0.006345103,-0.047140222,-0.0030562615,-0.07080302,0.048274413,-0.056576796,-0.012545035,-0.012439165,0.004445542,-0.00045554218,0.011103729,-0.015643613,-0.05019109,0.058186702,-0.034065533,-0.069672205,-0.07704177,-0.10176998,0.014660609,0.048287883,0.010452487,0.0013263435,-4.745972e-05,-0.011307005,0.09550235,0.004246836,-0.014455076,0.030705305,-0.06359499,0.031971622,-0.011687231,-0.032360796,0.09245973,-0.008540905,0.095353946,0.01934949,-0.0027911207,0.097844705,-0.072680235,-0.035362612,0.036559813,-0.030776668,-0.0039122677,0.010200654,0.029376851,0.012483674,0.015270866,0.005036192,0.067647755,-0.02887356,0.051315747,-0.106703185,-0.12033083,0.042565048,0.13639292,-0.033621702,0.0064668762,0.103041254,0.023477297,0.0041375905,-0.0033765503,-0.13353086,-0.0016355985,-0.07281645,0.018952278,-0.020767272,-0.030944424,-0.04663887,-0.013051541,-0.016870951,-0.020607406,0.049761295,-0.09543627,-0.015285922,0.03381143,0.04260106,-0.017639283,-0.05591641,0.0075470125,0.059969332,-3.2983754e-33,0.13689016,-0.09894928,0.06387994,-0.06809842,-0.052717187,0.03554773,-0.0227387,-0.07602023,0.0037869252,-0.04014457,0.022230336,0.045735337,0.024776798,-0.046686735,0.046468645,-0.011518705,-0.05208716,0.031885795,-0.03464608,0.011364068,0.0032668319,0.026027286,-0.022663431,0.0043048733,0.026096132,-0.030213831,0.0011586817,0.033293996,0.03692864,-0.062506944,-0.08920296,-0.009456084,-0.028333716,0.0034650846,-0.062282935,0.060306236,-0.04524226,-0.04407416,0.032701388,0.058083277,-0.012233325,0.124364406,-0.09855477,0.0933488,-0.039969835,0.12576102,0.002336844,0.072727054,0.011182633,-0.07096819,0.04230805,-0.021091014,0.048663232,0.008283987,0.055798754,0.078041926,-0.05775248,0.04626135,0.017127136,-0.011134211,-0.019748218,-0.054460242,0.01565695,-0.008146286,-0.059668336,-0.0060534496,-0.07848643,0.035319977,2.2345155e-06,0.009751033,0.025865609,-0.0048859804,0.0018028079,0.03613967,-0.07506313,0.008399529,-0.01517143,-0.07694939,-0.037243865,-0.060524926,-0.058293864,0.04515713,0.008066634,0.010308929,0.01841956,-0.010308986,0.07592281,0.032731302,-0.04672617,0.00041762696,-0.013270656,-0.0034592866,-0.044921577,0.022110349,0.028270843,-2.8176233e-08,0.040729243,-0.025332417,0.05002025,-0.0768744,0.0348391,0.0962014,0.07358324,0.059160683,0.05079021,0.0066449395,-0.047393944,0.045774207,-0.008977236,0.047044825,0.012119426,0.08233685,-0.06571674,-0.023954565,-0.011864704,-0.0063610654,-0.06237454,0.02796573,-0.06030787,0.070647016,-0.03415149,0.005674972,0.02638859,0.08897013,-0.043451276,-0.051874854,0.0033987942,-0.0048038224,0.052930303,-0.080706604,-0.039897542,0.041000996,0.010448907,0.049359623,-0.044967007,-0.024143616,-0.002840165,-0.102746285,-0.04324208,-0.0064150086,-0.034238134,0.027710063,0.0037197927,0.046660658,-0.016927253,-0.030869223,0.02929971,0.025401715,-0.00013981803,-0.023576096,-0.08287736,0.020881811,-0.09445468,-0.17875738,-0.0454605,-0.040584207,-0.013357946,0.014230079,0.1401034,-0.111527964 +2.1.3.12,The enzyme catalyses the last step in the biosynthesis of the aminocoumarin antibiotic novobiocin. The reaction is activated by ATP [1]. ,384,1.0,-0.07119176,-0.009352642,-0.061678015,-0.019834178,0.024577765,0.05022964,-0.112998955,0.04385948,0.10994722,0.03566986,-0.0065567633,0.0149661545,-0.0017899915,0.02859558,-0.051666446,0.017735891,-0.097450376,0.040031478,-0.010628225,-0.03807113,0.055127565,0.039774343,0.019987557,-0.018078756,0.1082865,0.023984363,0.05112498,0.04121744,-0.01000099,0.010737577,0.028789299,-0.020089649,0.0022687567,-0.07090594,0.061172053,0.05560454,-0.05441875,-0.033345994,0.16424224,-0.03550682,-0.044779003,-0.024973966,-0.054594647,-0.026743932,-0.0111060655,-0.053471737,0.005664699,0.077163965,0.0874696,-0.005266249,-0.015924668,0.016624194,-0.091563374,-0.021800857,0.13057983,0.05389653,-0.038663514,-0.09821965,0.002868859,-0.02072057,0.036171053,-0.05270149,-0.052913908,0.061367128,-0.022094898,-0.031086441,0.0035351736,-0.050341096,0.055891816,0.008166656,-0.094144195,-0.06109563,0.047803912,-0.0046923123,0.0005999373,-0.026566131,0.012473745,-0.0155563485,-0.008321536,-0.026377862,0.036909617,-0.0045736134,0.0055260463,0.08741364,0.042878866,-0.030808384,0.11658877,0.0017131207,0.07422184,0.046723668,0.018974094,-0.0088523375,0.037100468,-0.10729059,-0.047773503,-0.008969073,-0.049897738,0.016437989,0.0039307433,-0.0010688317,0.027454078,0.047447976,0.02909322,-0.07152679,0.0051049925,0.020499261,-0.009901425,0.12620798,0.017243233,0.038220625,-0.048892304,-0.033887237,-0.019528331,0.014125154,-0.058809053,0.11915618,0.038884673,-0.058884006,-0.09567044,0.0292511,-0.0077590193,-0.039960045,0.009177234,0.08979624,-0.053852886,0.022470666,-0.012783368,-6.5471826e-34,0.005934178,0.028399695,-0.00078053033,-0.029150888,0.036661375,-0.027497562,-0.061215494,-0.03368846,-0.01694953,-0.04494328,-0.04470561,-0.0850217,-0.020744283,0.0654355,-0.048620623,-0.07048103,-0.050727345,0.007040602,-0.016098542,0.06893352,0.0031407666,0.041012015,0.026958222,0.0031363417,0.008526588,0.065891236,-0.057400893,0.07698756,0.0398792,-0.01956393,0.0015362559,-0.023567405,-0.105467275,-0.04246382,0.04742638,-0.028568037,0.020287864,-0.026425485,0.093759224,0.061241828,-0.022633344,0.011230922,-0.03732148,-0.019909505,0.04916552,0.00077273505,-0.052766424,0.065514125,0.02699345,0.06544734,0.07087551,-0.05991626,0.07993818,-0.023565786,-0.0005971612,-0.0065256446,-0.036411688,0.022266975,-0.009172804,0.05409814,0.0015112191,0.0023034296,0.017949915,0.079113856,-0.0057774,-0.013560824,0.011090456,-0.033077784,0.045130488,0.08167982,-0.05946668,0.036407948,0.02235649,0.04112455,0.0053114146,0.008552167,-0.017435497,-0.029708546,0.02750637,0.008751841,-0.020431997,0.03920467,-0.034816716,-1.1131221e-05,-0.007137876,0.022693291,-0.040015098,-0.07673619,-0.061976913,0.057837218,0.03068073,-0.06332236,-0.0718546,0.039222483,-0.014978097,-1.9729494e-33,0.15750372,-0.101199254,0.049109176,-0.11493388,-0.11990078,0.080620706,-0.009366524,-0.08580879,0.013157714,-0.0049758307,0.016688982,0.0053996984,-0.014952726,-0.009404696,-0.02092503,-0.07765185,0.054212037,0.059002195,-0.041658957,0.02442449,0.011239646,0.049356047,0.024949672,-0.038657136,0.03589888,0.022873148,0.04144977,0.092335664,-0.012689382,0.034762047,-9.484333e-05,-0.04514504,-0.06484602,0.0009772496,0.0036103476,0.13994254,0.015218379,0.020385098,-0.014575461,-0.027698558,0.046387486,0.058100156,-0.050266556,0.033602487,0.021128515,-0.024815546,-0.038795054,0.040450197,-0.060710333,-0.13197187,0.07671154,0.026059829,0.0525599,0.0070039043,0.0009125929,0.015865019,0.07421252,-0.058515664,0.08609807,0.004366711,-0.07830993,-0.006350978,0.050625194,-0.036661565,0.017582122,0.052992072,-0.022679005,0.07040881,0.009276384,-0.032334745,0.04563947,0.006938128,-0.002104323,0.03361391,-0.000232318,0.040967565,-0.011431833,-0.06439003,-0.0045576333,-0.011412164,-0.06222898,0.00047424747,-0.06776599,-0.006892621,-0.10578104,-0.04264576,0.07444099,0.06391033,0.023304133,0.015015501,-0.00082195137,0.015829805,-0.028255891,-0.0045567,0.0050076093,-2.7306097e-08,0.03242999,-0.032889113,0.10222034,-0.040797263,0.07020125,0.07334629,-0.025181014,-0.05323187,0.04795022,-0.041613843,0.005721021,0.10803572,-0.0087655885,0.010871486,-0.044937555,0.035738852,-0.09309685,0.008531855,0.00021497159,-0.072711006,-0.11926485,0.037633512,-0.12300954,-0.022010243,0.052585885,-0.0891806,-0.01572672,0.00999945,-0.026695985,0.024704773,0.016826153,-0.010409038,-0.03807596,-0.05383798,-0.027414003,-0.023391247,-0.043642763,-0.048566446,0.034700315,-0.04980005,0.0048680026,0.012646847,-0.039029382,-0.012587825,-0.10204183,0.069955796,-0.012669898,0.0075048697,-0.08437524,0.004648789,0.04512755,-0.023067174,-0.012483274,-0.0919818,-0.117422365,-0.023759846,-0.016124086,-0.096655585,-0.0459965,-0.012599713,-0.05949262,0.017340643,0.13352771,0.0151405865 +2.3.1.224,"The enzyme is found in flowers like Clarkia breweri, where it is important for floral scent production. Unlike EC 2.3.1.84, alcohol O-acetyltransferase, this enzyme is active with alcohols that contain a benzyl ring.",384,0.99999994,-0.0557872,-0.029840736,-0.058967065,0.021760719,0.12923792,0.054153007,-0.037740935,-0.0973798,0.10716077,-0.09311827,0.07280891,-0.03308082,-0.12740436,0.01704539,-0.001754217,0.10275881,-0.0145490505,-0.003556062,-0.041436482,-0.04614208,0.06683399,0.021818422,0.10601225,0.026245894,-0.025124859,-0.016415806,0.0031476407,0.027285118,-0.036018416,-0.1310551,0.07560542,0.046352256,0.02620405,-0.054048248,0.03517615,0.017233012,-0.015983138,-0.10488857,0.0992305,0.023400377,0.053775586,-0.021673895,-0.01865305,-0.016112024,-0.04585633,-0.024145093,-0.007638432,0.0058350875,0.04891181,-0.030643398,-0.034256693,-0.07374118,0.012326348,-0.043397784,-0.0051058535,-0.022393607,0.029645829,0.025496488,-0.02239308,0.06257335,0.0905353,0.038208723,0.0052602156,0.049997177,-0.079730175,-0.05037641,0.021922866,-0.023327691,0.05754833,-0.11402159,-0.06273764,-0.065288745,-0.018756501,0.06601592,0.027617628,0.026774472,-0.0055367444,-0.018386545,0.0058107385,0.005387721,-0.01237902,-0.058972217,-0.021850897,0.14079002,0.048717294,0.020723492,-0.010157223,-0.048208337,-0.006375002,0.028555378,-0.0020450791,-0.08992081,-0.09881081,-0.1004587,-0.020302035,0.030674467,0.08136048,0.003912097,0.018941192,-0.003161903,-0.035931107,0.06010091,-0.004593391,-0.08220707,-0.04673245,-0.003270664,0.00048631406,0.029852804,0.04153496,-0.0015023625,-0.020670578,-0.05257207,0.04148877,-0.024723278,-0.034618583,0.021794029,-0.0263732,-0.055625737,-0.018170739,0.023433475,-0.03853096,-0.042435087,0.06747122,0.060889214,-0.033454075,0.053642064,-0.13328369,-5.4728514e-34,0.024333734,0.048704278,0.008735005,-0.02145282,0.007263413,-0.066774175,-0.02615834,-0.004221356,-0.085174404,-0.08822628,-0.098250784,-0.0199835,-0.0046324385,0.029397601,0.053048622,-0.03169446,0.016923813,-0.027453233,0.002796792,-0.020389423,0.050490472,-0.02338598,-0.081387326,0.0073210234,-0.03321919,0.027750352,0.006890682,0.022548795,0.004164122,0.016348043,0.022358045,-0.052306388,-0.012842033,0.04125021,0.0054811058,0.04029645,-0.029120134,-0.064611085,0.042111997,-0.015168411,0.0347658,0.106044285,0.10459211,0.045600682,-0.030799467,0.031800378,-0.08063279,0.064883456,0.13916472,0.025696931,0.004481772,-0.026336582,0.16078173,0.041921254,-0.0070630503,0.058135062,-0.02084229,0.014048426,0.06400796,-0.038376495,-0.017843971,0.0895104,-0.019214703,-0.05797421,-0.004785237,0.047086194,-0.0782843,-0.04605386,-0.02078899,0.035704285,-0.014885515,0.02516036,0.02646234,0.008986999,0.08800199,-0.009277242,-0.02184471,0.009280026,0.08465093,-0.024127446,-0.028335802,-0.065499984,0.0254884,0.028642053,-0.035615873,-0.06699073,-0.027867837,0.045495693,-0.046487276,0.07725433,0.056822985,-0.03042168,0.027652131,-0.0020484622,0.01779125,-1.1648276e-33,0.08622185,-0.043225836,0.10596983,-0.06751245,-0.03841181,0.07539648,-0.060046107,-0.033825967,0.032106023,0.010820702,0.062109176,0.010277617,0.054088578,-0.02641531,0.041927755,-0.0015777128,0.020532085,0.08853507,0.016886102,-0.013718266,-0.027868401,0.06529522,0.0007287082,-0.04351642,-0.0061426954,-0.011325722,0.002633122,-0.0016023424,-0.02806018,-0.030977715,-0.04243167,-0.015120186,-0.04607678,0.0133581655,-0.03426632,-0.0016800511,-0.0767095,-0.033435617,-0.032480825,0.08590826,-0.031324904,-0.008819693,-0.042931,0.07171602,0.084487855,0.061805606,-0.07103089,0.04532356,0.007690311,-0.040669277,0.030236863,0.04226189,-0.045212384,0.02899621,0.016492177,0.069969624,0.03970625,-0.017573163,-0.085864484,-0.050333392,-0.05024495,0.012673047,0.009409663,0.034802828,-0.057752904,0.037888132,-0.024934275,0.08003342,-0.007250962,-0.0039938726,0.04309754,0.013094714,-0.013420109,0.090288475,-0.020278849,-0.045946352,-0.08963106,-0.044806305,-0.0107264565,-0.032030642,-0.030997712,0.03523731,-0.040626615,-0.06513708,0.015072633,-0.085113645,-0.001559153,0.011445542,-0.019940177,0.023506127,-0.04047407,0.038712356,-0.0653334,0.02457884,0.05353927,-3.2436933e-08,-0.04348474,-0.04106781,0.09912797,-0.028569,0.019205643,-0.009870004,0.023497801,0.057572592,0.017909339,-0.021365432,-0.029186632,0.117743015,-0.006060218,-0.026020752,0.045174487,-0.0032470669,0.06874825,0.024890987,-0.021865616,-0.01340371,-0.007221128,0.032358952,-0.047003187,-0.021801608,0.0056899725,-0.03540035,0.032214038,0.03497523,-0.056528635,-0.07217105,0.01729663,0.069093384,0.024381002,0.018194178,-0.092828326,-0.006527918,-0.037545465,-0.047962464,-0.11953583,0.022160241,0.025733955,-0.10840193,-0.051628534,-0.025939012,0.06255508,0.041695718,0.10669608,0.0036637909,-0.005795099,0.014315071,0.015198096,0.023446389,0.0184541,-0.025454246,-0.0892103,-0.008330754,-0.033044126,-0.06762971,0.037970733,-0.06605137,0.043627497,0.023571033,0.19754048,-0.038270503 +2.3.1.225,"The enzyme catalyses the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association. 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+2.3.1.226,The enzyme is involved in the biosynthesis of the carbapenem beta-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. 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+2.4.1.301,Involved in the biosynthetic pathway of kanamycins. The enzyme characterized from the bacterium Streptomyces kanamyceticus can also accept UDP-alpha-D-glucose with lower efficiency [2].,384,1.0,0.0061846143,-0.047543317,-0.08148598,-0.015986526,0.012539661,0.05821449,-0.07792217,0.035327006,0.08649625,0.038524985,-0.011374915,0.06564799,0.018266624,0.0027955656,-0.017388077,-0.044748068,-0.041032683,0.04071665,0.036192052,-0.018726377,0.0876804,0.034341533,0.06856361,-0.040552385,0.086591855,-0.049953412,0.06327417,-0.01836702,-0.079000786,-0.055216752,0.008738434,-0.06354079,0.01988514,-0.03658561,0.084461644,0.13286419,-0.01438739,-0.057267867,0.098703764,-0.003435929,-0.002148159,-0.07293149,-0.003041556,0.040367022,-0.04373834,0.03930645,-0.014196197,0.016179409,-0.010752577,0.005997453,-0.06744389,-0.014846062,-0.010591495,-0.025984166,0.06184539,0.06396411,-0.024419984,0.008849254,0.005092013,-0.11205372,0.042698942,-0.008122936,0.065342076,-0.032631423,-0.11001736,-0.059586283,0.040768117,-0.059349664,0.05342493,-0.009240029,-0.031592116,-0.0024286264,-0.024937198,-0.0021523025,0.027362684,0.032303926,-0.05750445,-0.060746945,-0.023800686,-0.04383594,0.04777254,-0.02415082,0.04261212,0.073299214,0.013690582,0.0040984536,0.089500986,-0.03846346,0.024496423,0.08690117,0.023428911,-0.032433715,-0.018282086,-0.049266443,-0.079679586,-0.102116875,0.03195245,-0.0073631965,0.025513586,-0.039832793,-0.031681065,0.049807794,-0.04836244,-0.080034785,-0.04298023,-0.02537088,0.01927981,0.0022872698,-0.019175733,-0.04507431,0.01969553,-0.011309813,0.03663794,0.011272934,-0.04085028,0.082989186,0.09958005,-0.0845071,-0.05493384,0.032682464,-0.015667038,-0.037567396,0.045275446,0.03844406,-0.085063875,0.064655125,-0.041008234,-4.935935e-34,-0.00446789,0.027190143,-0.023739967,-0.05988926,0.06332514,-0.03560081,-0.113767415,-0.08274513,-0.015760772,-0.032283463,-0.08333734,-0.03811341,0.0028127555,0.061356448,-0.017041098,0.007261925,0.0048899525,0.052471753,-0.0009787431,0.02479705,0.03122847,0.07618815,0.0359579,0.016185775,0.008810079,0.013693962,-0.018967606,0.053331863,0.11762996,-0.007706063,0.019703332,-0.075561546,-0.023266602,0.011817121,0.038349148,0.01124701,-0.05087854,0.0074766395,0.035531618,0.045377307,-0.027076267,0.00035821155,-0.021962369,-0.04050735,0.02412822,0.020766325,0.002719867,0.05249933,0.019004945,0.03967694,0.063249245,-0.0058671073,0.07668013,-0.009617686,-0.02635694,-0.018981561,-0.042411186,-0.025068544,0.024214773,0.046846,-0.014699387,-0.0050987205,0.05980707,-0.021001806,0.052096732,-0.00483804,-0.03734629,-0.024945298,-0.026993355,-0.037644915,-0.027930275,-0.06751061,0.04968967,0.02231169,0.0041543557,0.01802992,-0.06321839,-0.0023905707,0.023937875,-0.035595566,-0.062363204,0.011974676,-0.06550896,-0.08628612,0.026382495,0.048198394,-0.1002667,-0.085103184,0.035963196,0.06872662,-0.05376462,-0.025032016,-0.08759789,0.023323445,0.04811393,-2.2509045e-33,0.07824427,-0.051219385,0.048043292,-0.015842896,-0.026803026,0.10763282,0.022602983,-0.10184442,0.094860174,-0.04903476,0.0764144,-0.015296739,-0.05691769,-0.035560932,0.008836003,-0.047915924,0.0010775307,0.08957828,-0.049419302,0.02538454,-0.001851328,0.07688484,-0.04664823,0.06534756,0.069717646,0.06847253,-0.062724225,0.12699926,-0.008563344,0.0020282078,0.06789358,-0.016233362,-0.03877754,-0.0025010016,-0.020188257,0.056583226,-0.050904322,0.08254439,0.016106041,0.02606894,0.04906006,0.011751446,-0.0223987,0.013420012,0.029976938,-0.03351576,-0.07310867,0.014627282,0.045281533,-0.08673835,0.0044889827,0.023943176,0.013285843,-0.030868825,0.020791685,0.08525367,-0.01260383,0.05539487,0.043736227,-0.017868193,-0.020497847,-0.0925139,0.094444774,0.046264917,0.03542683,-0.0030164039,0.052525584,-0.0072988966,0.046641313,-0.024726119,-0.008540151,0.050688732,0.010394023,0.111021906,0.03191807,-0.033292416,-0.093548246,-0.06172817,0.019867104,-0.046712477,-0.048018467,0.010081775,-0.021152627,-0.08686743,-0.017791793,-0.008355172,0.08109736,0.0052231587,0.023109341,-0.0047514457,0.015972057,-0.02488281,-0.015262411,0.002763636,0.09696199,-3.2676798e-08,0.121360905,-0.03291978,0.032756336,-0.0009792559,-0.031253494,-0.092746615,-0.03580207,0.02072874,0.013462233,-0.07597153,-0.016336294,0.111278236,0.041817572,-0.032571353,0.043103687,-0.027130738,-0.053130966,0.03357734,-0.043799628,-0.03641998,-0.08992164,-0.024810588,-0.12957813,0.0431843,0.06388763,-0.070816964,0.01954621,-0.013600881,0.0020480158,-0.04408374,0.074928194,-0.01768095,-0.037541162,-0.023479417,-0.035052955,-0.0069705825,-0.093988284,-0.0017802728,0.040312734,0.039440554,0.002934521,-0.044698834,-0.042309437,0.0067128767,-0.086708486,0.06784332,-0.0010883892,-0.01454966,-0.106210396,0.065699734,0.030368233,0.04005784,-0.013818457,-0.015743325,-0.08306573,0.030876022,-0.037855357,-0.012811479,-0.10377406,-0.05471808,-0.042131033,-0.007051218,0.17555857,-0.12404286 +2.4.1.302,"The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin. ",384,0.99999994,-0.074619815,-0.042549994,-0.101321384,-0.0065483665,0.017342545,0.060911026,-0.102466404,0.057091627,0.10732879,0.012039394,-0.035907604,0.0082580205,-0.012952071,0.05252915,-0.059679843,0.032828636,-0.07614118,0.009672112,-0.026592521,-0.035104126,0.03284306,0.059236065,0.0131866615,0.0042706016,0.09992638,-0.022597108,0.05083132,0.050198346,0.0022136015,0.022271853,0.05233437,-0.015305384,0.024685577,-0.06553148,0.064192966,0.04384707,-0.0496645,-0.044667035,0.14650147,-0.03885811,-0.04345174,-0.004611539,-0.06723905,-0.05135255,0.0017279547,-0.039638106,-0.015584861,0.07085773,0.07716718,0.04124033,-0.019434923,-0.005868597,-0.08880872,-0.002476272,0.12739436,0.06247028,-0.04042697,-0.13746013,-0.02275837,0.00073419284,0.036093716,-0.036789104,-0.0130884545,0.060401157,-0.05059962,-0.009032425,0.017323514,-0.035628665,0.030400075,-0.043947008,-0.08002358,-0.09572434,0.062356133,0.003838889,-0.010230618,-0.055591553,0.0063737333,0.002140434,-0.009197024,-0.031750713,0.03721251,0.012337432,-0.013515513,0.10042728,0.021943757,-0.0006939759,0.13034107,-0.0082419505,0.045755304,0.02636503,0.0076634903,-0.02495347,0.033737697,-0.10426777,-0.041827817,-0.038374297,-0.050038856,0.026474925,-0.0018618925,-0.029269101,0.016982727,0.038478967,0.02730029,-0.059204523,-0.029643346,0.0019892822,0.008864852,0.121997245,0.022719063,0.012933274,-0.031260755,0.0004715839,-0.035948284,0.03243076,-0.061370928,0.086979955,0.061268397,-0.060419712,-0.08488478,0.06343778,0.0042349105,-0.03507258,0.03313975,0.09370754,-0.02407881,0.0061588157,-0.0230607,-2.4126138e-33,0.029909706,0.014045823,-0.014489008,-0.028274374,0.058663417,-0.014987728,-0.06374129,-0.037815787,-0.008341491,-0.03911389,-0.058344863,-0.08834026,-0.01928684,0.079992644,0.00850953,-0.020646999,-0.045429323,-0.012131245,-0.033275023,0.072426066,-0.006666152,0.07166952,-0.019800732,0.029245812,0.0042085084,0.060584586,-0.06783511,0.07730319,0.066866696,-0.028999101,0.011380132,-0.005962905,-0.089112334,-0.017782077,0.06349145,-0.012655462,0.028248807,-0.027834786,0.065325856,0.07455021,0.011290977,-0.006687783,-0.04997493,-0.0092161475,0.06103655,-0.021374466,-0.05484382,0.042330626,0.036449805,0.032828674,0.04966682,-0.03199756,0.08309727,-0.020601643,0.019405484,0.011278167,-0.039280556,0.023458594,0.012498676,0.058584243,-0.02940884,-0.012070261,0.014960541,0.09066929,-0.0047414647,-0.017980188,0.011831586,-0.036256127,0.023370234,0.06300761,-0.05362771,0.04761835,0.024349434,0.059601486,-0.009194749,-0.029189724,-0.04658213,-0.020115044,0.038581256,-0.017081698,-0.032208543,0.01386196,-0.0033858495,-0.011364329,-0.060283646,0.0014753104,-0.018228216,-0.06177713,-0.043478016,0.0053497143,0.027863959,-0.068207696,-0.109923914,0.0035377087,-0.020263338,-1.7406652e-33,0.12446743,-0.120290235,0.03511751,-0.076792285,-0.10144921,0.11253218,0.00063008425,-0.046654582,0.013529999,-0.0037669044,0.018012116,0.020776987,0.0019064838,-0.023654344,-0.020962818,-0.056066114,0.026322743,0.030347653,-0.05944089,0.0029230872,-0.00076529523,0.029180786,0.05830829,-0.09321994,0.04502393,0.038155586,0.01719375,0.08218563,-0.0443619,0.044978496,-0.016927164,-0.031461723,-0.07920871,-0.048145875,0.003506877,0.10828604,0.013950163,0.004281767,-0.056205988,-0.059840627,0.015040403,0.046156533,-0.02794226,0.04657723,-0.014867726,-0.022036966,-0.051896647,0.01164173,-0.03758963,-0.09862802,0.07071578,0.027968269,0.07698143,0.018955164,-0.01604443,-0.012748798,0.05315448,-0.058966316,0.0713043,0.03217184,-0.05239992,-0.021204062,0.03851993,-0.011406934,0.019654587,0.04451604,-0.0046383664,0.049325835,0.056835484,-0.04507577,0.04747619,-0.02897539,0.030514557,0.067900926,-0.055824716,0.018279977,-0.04432736,-0.057701193,0.023562793,-0.017229775,-0.04492658,-0.023543227,-0.053357016,0.0138702085,-0.133187,-0.046629664,0.08154271,0.07956026,0.040307093,0.014055258,-0.003923085,0.022570575,-0.06313995,-0.011661251,0.016020399,-2.3723281e-08,0.07637335,-0.046473704,0.08952855,-0.050286032,0.06427812,0.029439526,-0.036415827,-0.05431713,0.026396228,0.009995277,-0.0182723,0.10545608,-0.058929842,-0.0015657842,-0.051335614,0.035223942,-0.04331972,0.033439007,0.008925017,-0.044089843,-0.108326845,0.05870482,-0.10840614,-0.039801333,0.04629263,-0.08849116,-0.017666025,0.02872444,-0.027469411,0.030531501,-0.027243491,-0.008958109,0.0018379255,-0.08881625,-0.077271074,0.019190988,-0.026656048,-0.07189224,0.024777642,-0.02885079,0.034645654,0.0250747,-0.007623994,-0.022937376,-0.07098586,0.048840635,0.00908922,-0.011549378,-0.052595966,0.002806373,0.022268081,0.00019111604,-0.010618095,-0.06976346,-0.147426,-0.00870327,-0.009092168,-0.11845379,-0.027648583,-0.019098148,-0.081605814,0.038621817,0.17679012,0.01422572 +2.4.1.303,"The enzyme is involved in the the biosynthesis of the O-antigen repeating unit of Escherichia coli O7:K1 (VW187). Requires Mn2+. cf. EC 2.4.1.343, UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase.",384,0.99999994,-0.02807201,-0.053194635,-0.093703724,0.016634949,0.02582188,0.011921831,-0.039710205,0.036673725,0.030695556,-0.04754534,0.03619306,-0.03115817,-0.036972735,0.0578099,-0.071972236,0.019311793,-0.0320845,0.021155024,-0.0005454474,-0.016134158,0.10910252,0.045970332,-0.032798246,-0.0075360313,0.073298216,0.011371291,0.045409422,-0.0027926846,-8.100819e-05,-0.089270234,-0.041843113,-0.05729208,0.16223377,-0.08492031,0.11497196,0.025052786,0.0603152,-0.047941633,0.0053067743,0.023684569,0.0063994695,-0.011126047,0.08445863,-0.038376857,-0.038193326,0.011938852,0.03012663,0.01320449,0.04062477,0.025646618,-0.017426465,-0.11725078,-0.02180859,0.05855767,0.10449419,-0.00017056835,-0.10943247,-0.09001552,-0.009632908,0.0068619484,0.03377352,0.0019293828,0.016692925,0.037072547,0.0071188845,-0.07080306,0.047124524,-0.05923575,0.0032173502,-0.0592866,-0.042921748,-0.011992217,-0.0145001905,0.04943642,0.0067010573,0.038137827,0.066605695,-0.02416263,0.121475,-0.012077124,0.03924517,-0.037842255,-0.024586111,0.036956787,-0.04970665,0.0029476776,0.0202987,0.050975718,0.049507104,0.002552502,-0.0016379611,-0.07927408,0.014828296,-0.06547683,-0.005003982,0.034659762,0.010742131,0.018989969,0.042403415,0.024005214,-0.037308786,0.04930851,0.015533847,-0.03637039,-0.034097567,-0.05753348,-0.0143409325,0.10902724,-0.017007044,0.0049736956,0.045426395,-0.020165466,0.035059065,-0.001695053,-0.040384695,0.069682546,0.031547047,-0.092660405,-0.07588979,0.033214856,0.062136713,-0.044831883,0.0020287696,0.112588294,-0.019960513,0.04067141,-0.032174803,1.39098855e-33,0.07837243,0.051528577,0.022533974,-0.04487549,-0.0113812005,-0.049044985,-0.026207618,-0.07253636,0.011261036,-0.034236196,-0.109889396,-0.096970975,0.06304919,0.02670408,0.012647929,0.013561841,0.028311035,-0.0013429157,-0.003068807,0.05788562,0.02484787,0.07889691,-0.051176153,0.008968328,0.02073937,0.081096806,-0.00013530924,-0.010013573,0.080970146,-0.0022516965,0.031307768,-0.07214685,-0.116706885,0.04691524,0.09746643,-0.06106308,-0.0524848,-0.09780049,0.020960875,0.04447083,-0.008167038,0.052547444,-0.056730647,0.047495864,0.08929758,-0.059308633,-0.04381569,0.03482449,0.060185216,0.07965342,0.033159416,0.046105247,-0.010078587,-0.025764605,-0.022787463,0.008327521,-0.05874808,0.029360287,0.036917455,0.036326937,-0.06539051,0.03874244,-0.025486099,0.057660837,0.014288605,-0.000695667,-0.033754382,-0.0635869,-0.028619183,0.035282705,-0.013286361,-0.11128234,4.706254e-05,-0.0036202734,-0.033258695,-0.061207615,0.020827278,-0.01888432,0.039598454,-0.034334935,-0.025935637,0.034395967,-0.03204881,-0.028172841,-0.06999728,0.019903997,-0.0015626836,-0.09380022,0.0014205104,0.05055967,0.013071164,0.0031784873,-0.062066082,0.041840147,0.0026923888,-2.7214367e-33,0.08771975,-0.09737022,0.074327454,-0.08254968,-0.1025413,0.05669655,-0.034763977,0.00030403683,0.015053747,-0.011199117,0.05503683,-0.008533065,0.030199734,-0.0326651,-0.018840432,0.00745264,0.03003089,0.09555229,0.0048757955,0.031030446,0.044220272,0.05207356,0.04849905,0.02638187,0.030702192,-0.0041637886,-0.002730976,0.0643956,-5.7760284e-05,0.050480124,-0.0069281575,-0.0810147,-0.015373489,-0.06568347,-0.05062054,0.01918411,0.02415613,0.0102535235,0.036971156,0.011692598,-0.03776325,0.028430052,0.002985336,0.011287672,-0.01909873,0.025410533,-0.013758839,0.039769422,0.05776037,-0.09914274,-0.0076589696,-0.016243264,-0.02580925,-0.010813369,-0.04003655,0.004876601,0.055781025,0.06875648,0.04190321,-0.044019233,0.018951742,-0.10958275,0.046954043,-0.015159437,0.06405691,0.0829307,0.027661124,0.011371816,-0.0065165767,-0.026909383,-0.030641563,-0.019188503,0.027043324,0.0216086,0.05299935,-0.0732915,-0.121719554,-0.03423701,0.04188554,-0.0031040448,-0.003319641,0.013043453,-0.0056008794,-0.0070728487,0.034540895,-0.08184303,0.12965809,0.15234637,0.01954042,0.04101781,-0.06083869,-0.040606357,-0.06383854,0.03999758,0.042516068,-4.1698474e-08,0.03721845,-0.119668245,0.012223584,-0.099300586,-0.027367845,0.042687267,-0.051640492,-0.054561242,0.052137546,0.0005559773,0.057355035,0.13715856,-0.0019267071,-0.029383214,0.05852657,0.0029734778,-0.026505912,0.024259528,-0.0371305,0.021819388,0.01173701,-0.0063110394,-0.08162428,-0.011053957,-0.0037332363,-0.017746052,0.010624308,0.11555571,-0.012563112,-0.09944591,-0.0051492,0.0210913,0.0063174046,-0.07595667,-0.12981366,0.057864036,-0.01909534,-0.0316814,0.023796916,0.048436686,-0.03789737,-0.0025773472,0.014052988,0.005976452,-0.05793302,0.027779728,-0.027002243,0.038053855,-0.08285493,-0.029395154,-0.005795609,-0.09806406,-0.02804304,-0.06344498,-0.06992717,-0.05518111,0.000515692,-0.079200864,-0.011113303,-0.014682225,0.012525922,0.005315722,0.13976215,-0.041518122 +2.4.1.304,"The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Shigella boydii B14. The activity is stimulated by Mn2+ or to a lesser extent by Mg2+, Ca2+, Ni2+ or Pb2+. 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+2.4.1.305,The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O56 and serotype O152.,384,1.0,-0.014946517,-0.043489847,-0.06607136,0.015428631,-0.008998751,0.008829915,-0.048054677,0.014112815,0.094248995,-0.08358198,0.02085945,0.021020118,-0.06411209,-0.0054489234,-0.06140692,0.0054987445,-0.017562091,0.034286205,-0.0047090533,-0.07487371,0.11810633,-0.027388545,0.0034585004,-0.0013509791,0.008342875,-0.01311884,0.043094125,0.008008321,-0.022644142,-0.072512425,0.02533311,-0.00060416973,0.08196002,-0.06808795,0.1008893,0.037629545,0.04714532,-0.08465233,0.079230405,-0.006512876,0.02475106,0.0063093905,0.020411987,0.0066728354,0.0019327726,-0.048505347,-0.025152385,0.036309026,0.035948463,-0.035159487,-0.031159589,-0.06544699,-0.05295821,0.0050729862,0.118413106,-0.016312052,-0.0066324663,-0.085469745,0.018429086,0.004195542,0.008682343,0.0071991147,0.04488343,0.0073014232,-0.021239368,-0.073793985,0.08430736,-0.07689142,-0.053088248,0.0010801991,-0.08857436,0.0074691093,0.0017132078,0.052389566,-0.009631895,0.006660854,-0.043084837,-0.019034008,0.049003586,0.055293925,5.0068295e-05,-0.021135857,-0.04966824,0.09107187,-0.031426642,-0.0531815,0.077308536,0.012148726,0.10654168,0.061415322,-0.07608404,-0.03785448,-0.00039705876,-0.072255105,-0.023650084,-0.04690819,0.054382227,0.009697318,0.05041161,-0.029008158,-0.029431183,-0.005793052,0.08772178,-0.05507051,-0.08548396,-0.048828416,0.020638423,0.117701605,0.033022504,0.009033493,0.00019102528,0.007937624,0.0021031548,-0.02064819,-0.03374123,0.029017966,0.0055393013,-0.07817059,-0.08450568,0.017454721,0.008228173,-0.068268806,0.058852483,0.097869664,-0.054815,0.0029973488,-0.06704351,1.1978125e-33,0.057351448,0.00903838,0.02344934,-0.04880306,0.04991706,-0.054293048,0.025439931,-0.019445054,-0.07682326,-0.031267412,-0.11592846,-0.13036634,0.042945974,0.03739623,0.0090500545,0.008777353,-0.014016768,-0.01959908,-0.009067592,0.023362013,0.017398236,0.09438153,0.02524714,0.026587257,0.055520866,0.026787382,-0.093739875,-0.01521306,0.029483242,0.025661979,0.09683936,-0.035195604,-0.12468401,0.00979777,0.0975538,-0.025555657,0.021022247,-0.038326923,0.054830417,0.007476482,0.043575082,0.08114618,0.031561323,0.0063319914,0.06311394,0.024415636,-0.0067133964,0.08386008,0.03645681,0.111060575,-0.017772455,0.044594295,0.033930566,-0.010716068,-0.06116153,-0.019039826,-0.074512765,0.02242025,-0.011964301,0.068375,0.017884536,0.050394766,0.005230978,0.019294908,-0.042123787,0.011015856,-0.0046794885,-0.0051068054,0.04315538,0.10514781,-0.025086213,-0.050026886,-0.050238233,0.013425323,0.0022727025,-0.053521857,-0.050520346,0.010138165,0.053396706,-0.005740757,-0.004628398,0.014377174,-0.033927195,-0.07327168,-0.08262553,0.07790695,-0.008611506,0.022533908,-0.0409317,0.11695339,0.09319938,-0.13410728,0.032285973,0.052652735,0.016039897,-3.571581e-33,0.05226592,-0.09999674,0.09126561,-0.10056992,-0.10543948,0.022206431,-0.032157414,-0.008049771,-0.051362038,0.01013177,0.046722174,0.008780253,0.042179376,0.0034353475,-0.03323883,0.0024955191,-0.06383287,0.12980482,-0.04370144,0.03593257,0.00539514,-0.0017002226,0.05928728,-0.05410307,0.066462725,0.07589924,0.012854413,0.034357123,-0.022497756,-0.030137617,-0.011810834,-0.022418564,-0.034501456,-0.063349135,-0.064897805,0.0050374675,0.0144915655,-0.017173363,0.04213857,-0.0010055164,-0.054738145,0.056642942,0.009010103,0.04563991,-0.021503182,0.03998105,-0.014206442,0.036539234,0.023499431,-0.07766311,0.010105757,-0.0023002164,0.0017931378,0.011156978,-0.028547144,0.013804341,0.007865541,0.029444927,-0.08214806,-0.0672963,0.023617381,-0.06266799,0.070688404,0.023143891,0.04296388,0.024823096,0.016855238,-0.025784867,0.0029651374,-0.008135788,-0.041852444,0.0022556677,-0.04504495,0.020467931,0.014384021,-0.03707161,-0.10600144,0.012624213,0.005434847,0.03531189,-0.032992333,-0.021661723,-0.02811206,-0.014625673,-0.066305354,-0.069419675,0.10278791,0.09599528,0.03316136,0.091861874,-0.068199396,0.006176128,-0.059350085,0.08419062,0.044073746,-2.9934604e-08,0.016939474,-0.11607239,0.008777551,-0.02687964,-0.020628555,0.04439413,-0.051732097,-0.030919846,0.037838582,0.021234868,0.061360423,0.09629563,-0.00583329,-0.028706338,0.03539808,-0.060301058,-0.03447878,-0.009037689,0.008301674,-0.005523038,-0.029336367,-0.011778668,-0.040908538,0.069246896,0.03305319,-0.062469494,-0.026270963,0.02001346,-0.03165279,-0.03631659,-0.046326347,0.006612733,-0.038894445,-0.065198846,-0.08998611,0.009512977,-0.044234984,-0.062490053,0.01984852,0.033191618,0.08028231,-0.05839329,-0.03419692,0.019230839,0.06694005,0.112442076,0.007590036,-0.042649742,-0.09778614,0.011118631,-0.02284049,-0.06340884,0.0030536267,0.02806573,-0.12328326,-0.017237782,-0.04336346,-0.065947734,-0.014918071,-0.013875754,0.015802244,0.032952182,0.13982965,-0.08320769 +2.4.1.306,The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype 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+2.4.1.307,The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O86.,384,0.99999994,-0.01676372,-0.056527954,-0.07571109,0.02545591,-0.042181503,0.04151388,-0.041049533,0.043908354,0.085000664,-0.081726626,0.014294093,0.01127728,-0.046141498,-0.004309105,-0.05073456,-0.00806995,-0.02749497,0.043081917,-0.0015595118,-0.08365114,0.1372027,0.005846244,0.013913297,0.019429408,0.011017153,-0.012904441,0.050073393,-0.008938815,-0.00018109554,-0.07008459,0.026047356,-0.014219484,0.104484916,-0.02933641,0.11038236,0.037905425,0.06879337,-0.07537859,0.053569183,0.025116723,0.018256072,-0.002176189,0.042194355,-0.018464053,-0.022955284,-0.031746134,0.006215797,0.014947833,0.037676863,-0.013982512,-0.01556547,-0.07697209,-0.07868989,0.012419191,0.11461065,-0.012249932,0.0049947347,-0.094721094,0.010766347,0.038529117,0.019551318,0.0070183747,0.0725552,0.042776283,-0.0241449,-0.08628157,0.09161655,-0.06587214,-0.049010467,-0.012967762,-0.035643097,0.00985337,-0.007630107,0.061889235,-0.009902842,0.009651321,-0.033529285,-0.024558928,0.019940753,0.032980848,0.024815306,-0.031571895,-0.03233176,0.06967276,-0.025237981,-0.05443133,0.07152971,0.0009104914,0.10373993,0.048536003,-0.06421235,-0.013372851,0.012320515,-0.08860866,0.010436897,-0.059975926,0.059510473,0.020936357,0.046656694,-0.03023889,-0.033903576,-0.013578017,0.059934445,0.002434947,-0.071565226,-0.045617286,0.025724478,0.120636635,0.009564201,0.01684075,-0.008965732,0.007695079,0.010122633,0.006420578,-0.061314307,-0.008249151,0.03081635,-0.07627866,-0.08119027,0.02034345,-0.010474027,-0.06543131,0.0654669,0.11534895,-0.054806273,0.0328749,-0.06453566,-1.2274691e-34,0.0401137,0.03190128,0.005586981,-0.0634167,0.04808247,-0.053093895,0.014279488,-0.009566392,-0.08802295,-0.017516894,-0.11044234,-0.09663953,0.053416185,0.056929253,0.027913805,0.014561394,-0.025451163,-0.0013735971,-0.021460569,0.0067424597,0.012923371,0.057057876,0.028410314,0.049394295,0.049944993,0.01751288,-0.07667301,-0.0071050534,0.033262867,0.001240428,0.09129401,-0.039563067,-0.13694252,0.006358335,0.094658665,-0.054549545,-0.0011942791,-0.032956645,0.024925843,0.021757554,0.011069014,0.074805796,0.026783876,-0.039541844,0.05033855,-0.012789341,-0.020456174,0.07018824,0.032189667,0.11326036,0.005150249,0.040132042,0.025078658,0.00478375,-0.088706784,-0.050157532,-0.06858637,0.020318478,-0.014674854,0.0604077,0.05434113,0.048587184,-0.010289626,-0.0023339703,-0.0364963,2.8223485e-05,-0.015049206,0.010797489,0.03801274,0.090847686,-0.021008192,-0.111183345,-0.066127025,0.014057721,0.007344888,-0.050324798,-0.08547268,-0.010210036,0.0380172,-0.031133464,0.030878726,0.022849163,-0.011258173,-0.05165357,-0.07271375,0.054512758,-0.017161328,0.01763346,-0.061482433,0.08821394,0.087816544,-0.11878541,0.038438257,0.04501306,0.011057837,-2.4174851e-33,0.03536302,-0.081958,0.062300403,-0.09775723,-0.0795342,0.027261961,-0.011207915,-0.006585593,-0.047329783,-0.014409286,0.03336375,0.03215522,0.05774268,-0.013198737,-0.033713717,-0.01676065,-0.052860904,0.14219789,-0.036820076,0.015667113,0.02070256,0.00917813,0.07520145,-0.07601217,0.0720803,0.035934694,0.0012808768,0.062047664,0.0063498723,-0.0047951923,-0.0022502386,-0.01740356,-0.056473542,-0.03318939,-0.07955612,-0.004200466,0.010411089,-0.024206726,0.070345305,-0.008272779,-0.03933347,0.014093187,-0.004551798,0.04475814,-0.0057939095,0.060415763,0.0025812732,0.064120896,0.0012557375,-0.06045914,0.019318582,0.008077415,0.011731231,0.017699199,-0.01981742,0.017944077,-0.000644047,0.012840334,-0.06585715,-0.069654346,0.015629975,-0.030088622,0.076253444,0.017505376,0.010721117,0.04226408,0.008194322,0.00046951883,-0.024460588,-0.024764497,0.007763881,0.019697553,-0.07235722,0.03886421,0.03096429,-0.068320036,-0.12833896,0.0048520267,0.0029509093,0.0390434,-0.03378074,-0.022855092,0.001201907,-0.0030005546,-0.035968065,-0.06673286,0.09845426,0.09993007,0.040276047,0.08388376,-0.046399184,-0.013983463,-0.03686183,0.09174518,0.04443813,-2.8482598e-08,0.02475123,-0.12725507,0.012496118,-0.061790317,-0.012762528,0.009480661,-0.03815281,-0.032772973,0.022444282,-0.005025667,0.043814804,0.07621361,3.912899e-05,0.014574202,0.044236735,-0.02773464,-0.039474472,-0.013311858,0.006520787,0.04094567,-0.035695158,-0.017844912,-0.04140386,0.07475668,0.018214788,-0.06319821,-0.015910696,0.03348443,-0.027636025,-0.031546354,-0.014969801,0.025239848,-0.07161584,-0.06820474,-0.10301709,0.005695322,-0.03227732,-0.019246241,-0.00068629044,0.0022298275,0.07301456,-0.05458283,-0.02634986,0.028069513,0.07858816,0.11792961,-0.034693547,-0.03277114,-0.089574486,0.0059231347,-0.010930648,-0.053492345,-0.033460844,0.02226068,-0.142745,-0.06934822,-0.04884778,-0.08856337,-0.02208005,-0.0027700055,0.026320532,0.032831084,0.16517317,-0.11493586 +2.4.1.308,The enzyme is involved in the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O86.,384,1.0,-0.01416221,-0.06044269,-0.075502776,0.022903066,-0.043239564,0.04266407,-0.040759623,0.041127354,0.08733302,-0.08070884,0.012209445,0.0113457,-0.04399563,-0.0067070215,-0.050018966,-0.009912293,-0.028444318,0.044081204,-0.002163432,-0.08292908,0.13852525,0.005743859,0.014312844,0.020650497,0.010248872,-0.013953519,0.05098202,-0.012825268,-0.004431249,-0.06776776,0.02499088,-0.016810175,0.10057753,-0.031093787,0.11258773,0.03948352,0.06662804,-0.07670399,0.054771032,0.024914004,0.019179894,-0.003702021,0.040922232,-0.020241505,-0.024314132,-0.031547733,0.006353704,0.013145799,0.038737055,-0.0149923535,-0.016604312,-0.076943114,-0.07611462,0.007466257,0.11676733,-0.012393392,0.0058048656,-0.094961435,0.011984973,0.03839902,0.021563323,0.0066438387,0.07396469,0.04240731,-0.024647666,-0.0858881,0.090057425,-0.06354876,-0.048809066,-0.014395356,-0.037648115,0.01095997,-0.009157227,0.06313479,-0.009629881,0.0109461825,-0.030989818,-0.022145769,0.019128567,0.03437715,0.02170999,-0.03422108,-0.030966977,0.065342575,-0.021021362,-0.05702454,0.07352788,0.001042391,0.10362858,0.049569625,-0.062684916,-0.012020946,0.014444138,-0.08785912,0.01124073,-0.06329224,0.057671126,0.022913236,0.045637608,-0.034162685,-0.03880266,-0.014349791,0.063435085,0.0054438384,-0.07209988,-0.049995054,0.02762309,0.12121424,0.008748111,0.016689772,-0.009208757,0.007402671,0.007209897,0.006387607,-0.061395336,-0.0033754678,0.031601433,-0.07953118,-0.08345225,0.021843532,-0.00987405,-0.06692033,0.067449935,0.115193054,-0.05447845,0.031157948,-0.060718052,4.098409e-34,0.039861538,0.033040896,0.0042168763,-0.06285915,0.049262494,-0.052632906,0.013474197,-0.009585479,-0.08926989,-0.018462881,-0.10967165,-0.09837315,0.05366574,0.057571683,0.027715705,0.018247811,-0.024164695,-0.00096737,-0.022144852,0.004699467,0.012160302,0.05585853,0.029100312,0.048294015,0.048443533,0.015165063,-0.07736031,-0.006535701,0.033672318,0.0012862482,0.09175872,-0.03901585,-0.13308771,0.0065425904,0.09426361,-0.051696863,-0.00058159383,-0.030171342,0.02536818,0.023761785,0.009756684,0.07802283,0.026639065,-0.04238496,0.049301833,-0.0139189,-0.023557933,0.06792039,0.03150026,0.112411596,0.005901021,0.042703133,0.024252312,0.005577169,-0.088325016,-0.052989073,-0.06947761,0.019383727,-0.014542447,0.06226339,0.053666484,0.049911227,-0.009511019,-0.0027011137,-0.035272855,0.0006471228,-0.0115992185,0.012896342,0.04020476,0.09192303,-0.022206515,-0.112112336,-0.06465248,0.012991929,0.0057330295,-0.05131306,-0.08333898,-0.011485499,0.039417062,-0.030659432,0.031996794,0.024151728,-0.011574934,-0.05033907,-0.07171011,0.053328596,-0.018257279,0.017806964,-0.06000963,0.08636407,0.08865415,-0.11803486,0.039940007,0.04569373,0.010071157,-2.9425632e-33,0.034457516,-0.08091049,0.06511204,-0.09892857,-0.08351167,0.029981548,-0.011269518,-0.0061233095,-0.04778719,-0.014212701,0.03467537,0.031753514,0.05926661,-0.010128788,-0.034364756,-0.016642272,-0.054148532,0.1399041,-0.037012905,0.015456611,0.023289619,0.0074366466,0.074762166,-0.079445265,0.06931413,0.035698455,-0.0021868378,0.062759615,0.0024245954,-0.0067628473,-0.0028543493,-0.017359313,-0.056670174,-0.033353847,-0.08189616,-0.0048312857,0.011782738,-0.023346322,0.07142988,-0.004443756,-0.041064765,0.013802375,-0.0030955481,0.04445561,-0.008182496,0.055537842,0.002891297,0.061912097,-0.00029987903,-0.06153225,0.018892504,0.008346937,0.0104678795,0.017052645,-0.02124568,0.016625267,0.0010900404,0.0134585975,-0.067646295,-0.07137839,0.015953863,-0.027619988,0.07658324,0.015118328,0.009860214,0.039089344,0.009835981,0.00038711226,-0.025275182,-0.024474574,0.0059497636,0.020260632,-0.07059421,0.039936863,0.03175263,-0.07066193,-0.128883,0.0063436236,0.0024713972,0.041348778,-0.03558996,-0.021811098,0.0029190977,-0.0043203677,-0.03447672,-0.066397175,0.096170425,0.0994037,0.043998357,0.082249194,-0.04598576,-0.016088923,-0.035646647,0.09312785,0.042839963,-2.8340372e-08,0.024116965,-0.1255939,0.012192333,-0.060125053,-0.0146595985,0.009535927,-0.039210655,-0.037668366,0.019627215,-0.009385287,0.043871447,0.07675105,-0.0008622582,0.015611707,0.042702172,-0.026797755,-0.042135064,-0.014531443,0.007832112,0.042910866,-0.033234548,-0.017406212,-0.03915778,0.074738815,0.019820763,-0.06140953,-0.016268915,0.033701263,-0.031074543,-0.030915087,-0.015114899,0.023453023,-0.06882092,-0.06580257,-0.10272449,0.0037003069,-0.03275692,-0.018796658,-0.004175298,0.0028366786,0.072207265,-0.05553291,-0.023720443,0.02823407,0.0780396,0.12109568,-0.036106024,-0.03462523,-0.08568572,0.00903724,-0.013167999,-0.054851666,-0.03275689,0.024559777,-0.1399239,-0.06597348,-0.05070099,-0.08604657,-0.022225464,-0.004647859,0.029005613,0.02876772,0.1621004,-0.115474746 +2.4.1.309,The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O86.,384,0.99999994,-0.01676372,-0.056527954,-0.07571109,0.02545591,-0.042181503,0.04151388,-0.041049533,0.043908354,0.085000664,-0.081726626,0.014294093,0.01127728,-0.046141498,-0.004309105,-0.05073456,-0.00806995,-0.02749497,0.043081917,-0.0015595118,-0.08365114,0.1372027,0.005846244,0.013913297,0.019429408,0.011017153,-0.012904441,0.050073393,-0.008938815,-0.00018109554,-0.07008459,0.026047356,-0.014219484,0.104484916,-0.02933641,0.11038236,0.037905425,0.06879337,-0.07537859,0.053569183,0.025116723,0.018256072,-0.002176189,0.042194355,-0.018464053,-0.022955284,-0.031746134,0.006215797,0.014947833,0.037676863,-0.013982512,-0.01556547,-0.07697209,-0.07868989,0.012419191,0.11461065,-0.012249932,0.0049947347,-0.094721094,0.010766347,0.038529117,0.019551318,0.0070183747,0.0725552,0.042776283,-0.0241449,-0.08628157,0.09161655,-0.06587214,-0.049010467,-0.012967762,-0.035643097,0.00985337,-0.007630107,0.061889235,-0.009902842,0.009651321,-0.033529285,-0.024558928,0.019940753,0.032980848,0.024815306,-0.031571895,-0.03233176,0.06967276,-0.025237981,-0.05443133,0.07152971,0.0009104914,0.10373993,0.048536003,-0.06421235,-0.013372851,0.012320515,-0.08860866,0.010436897,-0.059975926,0.059510473,0.020936357,0.046656694,-0.03023889,-0.033903576,-0.013578017,0.059934445,0.002434947,-0.071565226,-0.045617286,0.025724478,0.120636635,0.009564201,0.01684075,-0.008965732,0.007695079,0.010122633,0.006420578,-0.061314307,-0.008249151,0.03081635,-0.07627866,-0.08119027,0.02034345,-0.010474027,-0.06543131,0.0654669,0.11534895,-0.054806273,0.0328749,-0.06453566,-1.2274691e-34,0.0401137,0.03190128,0.005586981,-0.0634167,0.04808247,-0.053093895,0.014279488,-0.009566392,-0.08802295,-0.017516894,-0.11044234,-0.09663953,0.053416185,0.056929253,0.027913805,0.014561394,-0.025451163,-0.0013735971,-0.021460569,0.0067424597,0.012923371,0.057057876,0.028410314,0.049394295,0.049944993,0.01751288,-0.07667301,-0.0071050534,0.033262867,0.001240428,0.09129401,-0.039563067,-0.13694252,0.006358335,0.094658665,-0.054549545,-0.0011942791,-0.032956645,0.024925843,0.021757554,0.011069014,0.074805796,0.026783876,-0.039541844,0.05033855,-0.012789341,-0.020456174,0.07018824,0.032189667,0.11326036,0.005150249,0.040132042,0.025078658,0.00478375,-0.088706784,-0.050157532,-0.06858637,0.020318478,-0.014674854,0.0604077,0.05434113,0.048587184,-0.010289626,-0.0023339703,-0.0364963,2.8223485e-05,-0.015049206,0.010797489,0.03801274,0.090847686,-0.021008192,-0.111183345,-0.066127025,0.014057721,0.007344888,-0.050324798,-0.08547268,-0.010210036,0.0380172,-0.031133464,0.030878726,0.022849163,-0.011258173,-0.05165357,-0.07271375,0.054512758,-0.017161328,0.01763346,-0.061482433,0.08821394,0.087816544,-0.11878541,0.038438257,0.04501306,0.011057837,-2.4174851e-33,0.03536302,-0.081958,0.062300403,-0.09775723,-0.0795342,0.027261961,-0.011207915,-0.006585593,-0.047329783,-0.014409286,0.03336375,0.03215522,0.05774268,-0.013198737,-0.033713717,-0.01676065,-0.052860904,0.14219789,-0.036820076,0.015667113,0.02070256,0.00917813,0.07520145,-0.07601217,0.0720803,0.035934694,0.0012808768,0.062047664,0.0063498723,-0.0047951923,-0.0022502386,-0.01740356,-0.056473542,-0.03318939,-0.07955612,-0.004200466,0.010411089,-0.024206726,0.070345305,-0.008272779,-0.03933347,0.014093187,-0.004551798,0.04475814,-0.0057939095,0.060415763,0.0025812732,0.064120896,0.0012557375,-0.06045914,0.019318582,0.008077415,0.011731231,0.017699199,-0.01981742,0.017944077,-0.000644047,0.012840334,-0.06585715,-0.069654346,0.015629975,-0.030088622,0.076253444,0.017505376,0.010721117,0.04226408,0.008194322,0.00046951883,-0.024460588,-0.024764497,0.007763881,0.019697553,-0.07235722,0.03886421,0.03096429,-0.068320036,-0.12833896,0.0048520267,0.0029509093,0.0390434,-0.03378074,-0.022855092,0.001201907,-0.0030005546,-0.035968065,-0.06673286,0.09845426,0.09993007,0.040276047,0.08388376,-0.046399184,-0.013983463,-0.03686183,0.09174518,0.04443813,-2.8482598e-08,0.02475123,-0.12725507,0.012496118,-0.061790317,-0.012762528,0.009480661,-0.03815281,-0.032772973,0.022444282,-0.005025667,0.043814804,0.07621361,3.912899e-05,0.014574202,0.044236735,-0.02773464,-0.039474472,-0.013311858,0.006520787,0.04094567,-0.035695158,-0.017844912,-0.04140386,0.07475668,0.018214788,-0.06319821,-0.015910696,0.03348443,-0.027636025,-0.031546354,-0.014969801,0.025239848,-0.07161584,-0.06820474,-0.10301709,0.005695322,-0.03227732,-0.019246241,-0.00068629044,0.0022298275,0.07301456,-0.05458283,-0.02634986,0.028069513,0.07858816,0.11792961,-0.034693547,-0.03277114,-0.089574486,0.0059231347,-0.010930648,-0.053492345,-0.033460844,0.02226068,-0.142745,-0.06934822,-0.04884778,-0.08856337,-0.02208005,-0.0027700055,0.026320532,0.032831084,0.16517317,-0.11493586 +2.5.1.108,"A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The enzyme is a member of the 'AdoMet radical' (radical SAM) family and generates the 3-amino-3-carboxypropyl radical by an uncanonical clevage of S-adenosyl-L-methionine. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis.",384,0.99999994,0.04029828,0.0064355507,-0.11155837,-0.06505101,0.068303674,0.05653793,-0.07606477,0.08167102,-0.035697322,0.044712786,0.044059828,-0.07596951,-0.06372795,0.08623777,-0.011021488,-0.032633446,-0.14938216,0.009048607,-0.019815994,-0.08709367,-0.008192537,0.05035561,0.029167423,-0.06624972,0.037739303,-0.00038428034,0.032838054,0.005759653,-0.034328558,-0.06553993,0.05569134,-0.075558275,0.06225803,-0.051159453,0.08844448,0.033711433,-0.043392334,-0.0137614105,0.0802418,0.04308197,0.011085023,0.016684903,-0.0070172064,-0.029541925,0.015555192,0.046543587,0.047334123,0.01805172,0.07784045,0.009377632,-0.028605176,0.0034596273,-0.0043885363,-0.044415627,0.04661912,-0.045632243,0.006299014,-0.063794,-0.0018234507,0.012252819,0.08558365,-0.06669555,0.04257533,-0.019863728,0.01445934,-0.019192677,0.09913037,-0.089713745,-0.0002095181,0.012143929,-0.06826487,-0.010401871,0.0012301862,0.12227504,0.04429533,-0.007847604,-0.05445357,-0.009590923,0.015571675,0.04189954,0.015512174,-0.060459994,0.0342459,-0.039877355,-0.012044252,0.0075873137,0.0038561234,-0.061503794,0.056095093,0.051454578,0.018153992,-0.081481844,-0.0348929,-0.047545504,-0.019435184,-0.0038793941,0.007338569,0.05298559,-0.065747514,-0.03501094,0.0029117141,0.042783067,-0.09348154,-0.031104378,-0.0045064394,0.021711215,-0.014381394,0.124116085,-0.027878901,0.029492486,0.03365259,0.009839844,0.011638233,-0.09753363,0.010755694,0.0749281,0.025012296,-0.074271195,-0.037198193,0.026240543,0.043347754,0.05646494,0.07427374,0.09624173,-0.053378064,-0.036269557,-0.11491863,3.472042e-33,0.036519848,0.106283754,0.02989805,0.03381319,0.02434016,-0.025566615,-0.113967024,-0.0013246413,0.031291373,-0.093953714,-0.073051125,-0.04368331,0.12952891,-0.043815117,-0.12880686,-0.08159659,0.031732943,-0.042276815,0.06940214,-0.032342356,-0.0021257023,0.04015303,0.031736642,-0.0037105612,0.04125287,0.006188313,-0.012193335,-0.027296063,0.063944444,0.027198222,-0.10467891,-0.048070848,-0.10693006,0.045445558,0.05952444,-0.07577512,-0.023571316,-0.1259283,0.029525591,0.034208704,0.077119164,0.033043843,0.044562593,-0.05563606,0.042412557,-0.0663903,0.02444225,0.04090508,0.022131637,0.028023133,0.055623766,-0.008435353,0.1034934,-0.012144893,-0.047790986,-0.005506843,0.015276112,-0.035130996,0.09342272,0.10001306,-0.0003384926,0.060055606,-0.02072109,0.059493832,0.017062582,-0.04073036,-0.06692926,-0.045464765,-0.0384246,0.09093724,0.005065535,-0.057288777,0.08689689,0.030592099,0.033412308,-0.04874443,-0.070392095,0.08242584,-0.02079766,-0.027397357,-0.03199551,0.029463194,-0.05601354,0.0057515944,-0.02588111,-0.030618116,-0.018083528,-0.042984996,0.024548946,0.038890842,0.009540172,-0.035583857,-0.013026784,0.0027567723,0.076931246,-5.517817e-33,0.056570802,-0.06327433,0.00019784922,0.010558962,-0.036378946,0.07880605,0.069704935,0.05884124,0.029731983,-0.06681774,0.09041289,-0.034924597,0.006519508,-0.115961865,0.016310323,-0.04482661,0.05055813,0.08235455,0.027068948,0.01529167,0.041349478,-0.0144445505,-0.02143298,0.014213848,0.049045637,-0.005291785,-0.0015156115,0.011891798,0.025247201,0.0047217915,-0.022283737,-0.027147977,-0.03720855,-0.03593068,-0.016621748,-0.005276834,-0.051754393,-0.019248528,0.030273296,0.008994719,0.036485147,0.06129341,0.017743884,0.053263124,0.025177622,0.07577888,-0.04640226,0.12076387,0.033713028,-0.071366414,-0.005359415,-0.002844222,-0.04432753,-0.03240656,0.002878207,0.021978835,0.08735406,-0.041776713,0.011005124,0.040070917,0.0030463743,-0.08746752,0.029724522,0.010369639,0.011149491,-0.009482061,-0.068589814,0.026918195,0.056397505,-0.031192208,0.020104371,-0.07050576,0.02814111,0.038586106,-0.023421826,0.029805226,-0.015537869,-0.03659991,0.08073711,-0.018926706,-0.029726634,-0.08021651,0.02975786,-0.025798569,-0.019825162,-0.12810877,0.036954477,0.0199987,-0.0062888335,-0.05790717,0.006462653,-0.030979112,-0.04569863,0.07441603,0.059535485,-4.572484e-08,0.02332596,-0.014200122,0.056649745,-0.021246176,0.008401078,0.013520309,-0.010081814,-0.006279274,0.023229014,-0.0587349,0.014566238,0.07152952,0.00463869,-0.013140726,0.0008853704,0.0068161106,-0.060768362,0.040548023,-0.016086202,0.043412454,-0.064840406,-0.023525763,-0.059965357,-0.03389728,-0.009888292,0.0010290799,0.034619793,0.07538656,0.03242196,-0.115927145,0.020070111,-0.062282834,-0.025530566,-0.009385409,-0.14333987,-0.026111681,-0.07172878,-0.03797699,0.0126374625,0.025232777,0.06396622,-0.027835434,-0.057696715,0.03152355,-0.046175014,0.050128542,-0.012782002,0.039563984,-0.103851944,-0.07447785,0.0050824885,0.028974764,0.0053365943,-0.013698868,-0.05952225,-0.0062718936,-0.05872881,-0.065176636,0.034437157,-0.046266396,0.049510613,0.027826734,0.07260396,0.05257147 +2.5.1.109,"The enzyme from the fungus Aspergilus sp. MF297-2 is specific for brevianamide F [1], while the enzyme from Aspergillus versicolor accepts a broad range of trytophan-containing cyclic dipeptides [2]. Involved in the biosynthetic pathways of several indole alkaloids such as paraherquamides and malbrancheamides. ",384,1.0,0.0600835,-0.054685317,-0.14315082,-0.02689604,0.0045567816,0.036270004,-0.07743899,0.05709048,0.04300116,-0.018885413,0.057928205,-0.07700407,-0.056629773,0.050188217,-0.08612839,0.05495957,0.01765384,-0.013617675,0.049176782,-0.032428585,0.0096008945,0.07983565,0.022062842,0.03024378,-0.0012865117,0.016731953,0.009802125,0.005352429,0.0008648659,-0.116806515,0.006865408,-0.0041697095,-0.002336078,-0.0073434194,0.0034102076,0.032832608,-0.14249305,0.06311103,0.1114923,0.038382914,-0.036656205,-0.034191173,-0.051987484,-0.028251072,-0.09806382,-0.01873647,-0.02869173,0.021979555,0.064905375,0.049623948,-0.028058792,-0.0065804627,-0.012319627,0.053473335,0.015071554,-0.044251416,-0.052133035,0.03793169,-0.0007567344,0.037558313,0.026219422,0.040000457,0.010580677,-0.003864887,-0.07132859,-0.022167237,-0.07549176,-0.062821686,-0.036928616,-0.024686398,-0.008304332,-0.117880225,0.028290216,0.003563107,0.052080654,0.071298,-0.03361601,-0.005387657,-0.04932776,-0.09544764,0.07130677,0.0076149846,0.06670742,0.06868844,-0.025170704,0.012613048,0.059752427,0.02514512,0.08767847,-0.012069294,0.14748284,0.032585908,0.01977802,-0.044815376,-0.03466129,0.08575429,0.032732118,0.050304525,2.7297801e-05,-0.0471806,0.041652985,-0.029653823,-0.08601339,-0.03418609,-0.04654768,-0.029769216,0.0011380882,-0.0068844804,0.060481593,-0.06999351,-0.008199128,-0.0076194,0.0735459,-0.023241322,-0.003930645,-0.011778212,0.02454386,-0.017865049,0.0053437683,-0.06720965,0.02662226,0.023843177,0.01972816,0.023706324,0.031216778,0.05990469,-0.086871415,4.5876183e-33,0.11122027,0.06776754,-0.028564965,-0.0043499796,-0.021455992,-0.1303698,-0.02338224,0.007286799,-0.025087109,-0.016471984,-0.12949167,-0.068025835,-0.013919921,-0.028286833,0.028731786,0.014622901,-0.041126598,-0.04421762,0.015095912,-0.0041782553,0.0058724447,0.008273345,-0.08431924,0.045385856,-0.029993635,0.05628684,0.077389084,0.037032474,0.061285023,-0.05347331,-0.010585653,-0.0043757246,-0.08708345,0.028449655,0.044287298,0.010686998,0.020768506,0.013804656,-0.08844957,0.014757018,0.013113442,0.09741045,0.0075040553,-0.04694852,0.10289735,-0.03661361,-0.031607658,0.11400058,0.09315448,0.07110872,0.00082651863,0.01019093,0.10903557,0.037911512,0.030170249,0.057086695,-0.017184393,0.06368917,0.039726675,0.047648683,-0.07978003,-0.06943735,-0.014237754,-0.008961671,0.0061481986,0.020211253,-0.0017021303,-0.065603554,-0.044245187,0.018280946,-0.06880147,-0.026046677,0.020326668,0.018051704,0.01995229,-0.030604297,-0.0079498375,-0.06739409,0.018043399,-0.025603533,0.023131339,-0.029687017,0.025716592,-0.006458127,-0.03275176,-0.087118715,-0.042211752,-0.066034555,0.027641485,0.050605837,-0.03544089,-0.044845294,-0.08045573,0.0739615,0.03320596,-4.5944153e-33,0.08137069,-0.14649016,0.061853636,0.041295696,-0.055792205,0.076007865,-0.011146992,-0.009948454,0.027530877,0.009931797,0.09493071,0.027710605,0.052286744,0.0031968062,-0.061676886,-0.008512971,0.027220657,0.1267749,-0.022359997,-0.01592114,-0.06872147,0.106327735,-0.01498207,-0.023161104,0.061775707,0.0879888,0.03936598,0.07597997,-0.01494916,0.035143193,0.0537861,-0.01642598,-0.046099514,0.01582778,-0.007173835,0.09532494,-0.016118428,-0.035222143,-0.02807494,0.059936967,-0.025646634,0.018964818,0.035402134,0.016360853,0.052681006,-0.030650694,-0.08727104,0.06906119,0.05383103,-0.10707166,-0.017140504,-0.014013631,-0.006508824,-0.003997268,0.010306768,-0.028250176,0.06693278,-0.030416902,0.03417894,-0.02746743,-0.032498587,-0.02071515,0.029769551,-0.012646913,-0.005008564,0.029983899,-0.054435354,-0.008419172,0.032187622,-0.005258159,0.03642632,-0.06332187,0.04730985,0.097160116,-0.0024154577,-0.03940737,0.037516803,-0.049991228,0.007559663,0.02079316,0.04276952,0.017746916,0.037708372,-0.034629084,-0.021144547,0.005129717,0.014863199,0.0355184,-0.02964676,-0.0254152,0.025553083,-0.025179531,0.032166418,0.07948256,0.10794158,-3.857105e-08,0.06369512,-0.0124316085,-0.010779147,-0.08976669,-0.0072719236,0.003122715,-0.005526019,-0.036951587,-0.028958311,-0.058154985,-0.04761244,0.048210695,-0.012469769,0.10772681,0.07524867,-0.01661981,0.014667786,0.0374845,-0.023167105,-0.0089498125,-0.06334766,-0.03244442,-0.07320229,-0.059651986,0.017854866,-0.020394912,0.040696897,0.0029194062,0.0414849,0.0047565005,-0.007751963,0.030435458,0.038394682,-0.049004078,-0.016441619,0.043682244,-0.07593971,0.015198212,0.014346817,0.031298045,0.011425523,-0.08323869,-0.10085468,-0.02497619,-0.0824498,-0.037500203,-0.008579998,0.03240724,-0.013468836,-0.019574927,0.009676146,-0.06224161,0.04385047,-0.0687972,-0.09175035,-0.03862098,-0.0026102697,-0.023154302,-0.0032338991,-0.17301324,-0.04132132,0.0022963714,0.12053222,-0.019590577 +2.5.1.110,The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen. ,384,1.0,0.05283147,0.006339974,-0.1184341,0.021922257,-0.0011805925,0.08072129,-0.066672735,0.010136943,0.06601126,0.0016283294,0.031437844,-0.07991328,-0.058846314,0.061398525,-0.10998531,0.03863425,-0.014155442,0.068642534,-0.02362277,-0.06896134,-0.029165424,0.035573706,0.07941441,-0.021379745,0.024405917,-0.019927584,-0.06105149,-0.00937009,-0.03177851,-0.06643395,-0.038757555,0.0088701965,0.016873349,0.0057929405,0.019618941,0.054266557,-0.112163834,0.020516502,0.12122204,0.023221616,-0.09919877,-0.07536157,-0.043516424,-0.018858219,-0.081175156,0.02456583,-0.0064440984,0.028191086,0.08162732,0.012027378,0.002614553,0.03568598,0.016435144,0.047640007,0.104634926,0.004526098,0.021396024,-0.020567996,-0.06988375,0.047523364,0.017534884,0.07243117,-0.019196963,-0.02673253,-0.09745117,-0.049055554,-0.015989862,0.0031697436,0.0012598585,-0.029425183,0.012139974,-0.08208646,0.06362728,-0.05296056,0.05239848,0.11567121,-0.01122636,0.0074174684,-0.036470573,-0.083820805,0.10397008,0.0062972493,0.046379168,0.028832564,-0.032037202,-0.052698907,-0.009852818,-0.010385917,0.03279716,0.050794262,0.0785282,0.021294804,-0.020280456,-0.07852293,0.024556063,0.009699686,0.031759974,0.0820967,0.011842228,-0.06166741,0.005136937,-0.014949279,-0.023608316,-0.024781704,0.0027872347,-0.042164292,-0.05203184,0.009206907,0.08203783,-0.09105661,-0.0006518909,0.0131908385,0.07911517,-0.04155491,-0.018537283,0.001257111,0.014939707,-0.009818472,-0.020602236,0.014190042,0.004276099,0.041526794,0.034090083,0.08588453,-0.019806096,-0.013709251,-0.03921872,2.8802097e-33,0.09566306,0.066103935,-0.08528791,-0.010942904,0.057778604,-0.08017992,-0.027432363,-0.021687547,-0.018146133,-0.0022754828,-0.09474946,-0.024564324,-0.044501826,0.06099098,-0.0036449134,0.0015509824,-0.023861008,-0.072876625,0.019191518,-0.051748656,0.036353238,-0.014913828,-0.075376034,-0.049447015,-0.033728275,0.079322755,0.016621364,0.08856831,0.0115444185,-0.046427574,0.009270688,-0.04208479,-0.083090186,-0.010850036,0.034067832,0.026337592,-0.022670085,0.017743777,-0.0696654,-0.03948606,0.029190661,0.08289041,-0.052680165,-0.057817847,0.05331962,0.04409252,-0.07469029,0.11557242,0.10734976,0.048947982,0.07522946,-0.03881086,0.09356606,0.029518092,0.0068814657,0.0058579077,-0.018945158,-0.011070948,-0.009594103,0.08904763,-0.08861605,-0.026581079,-0.042638917,0.025324374,-0.0015647744,-0.0208977,-0.0353916,-0.07894201,0.029856043,0.06091121,-0.08365107,0.018206505,-0.03465782,0.007933906,-0.0101144435,-0.012040963,-0.056966495,-0.05350598,-0.05903181,-0.011468206,-0.003453213,-0.019204559,0.023853267,0.0012067788,-0.03203145,-0.04650678,-0.058835518,-0.053513784,0.004318984,0.034728438,-0.056766797,-0.060761806,-0.025258921,0.08356144,0.0632965,-5.3160817e-33,0.021353697,-0.09142827,-0.0036913268,-0.03181016,-0.09322663,0.10258053,-0.00999431,0.04368176,-0.020637963,0.0015218654,0.046126306,-0.009783598,0.11029077,0.05504539,-0.08269461,-0.05751533,0.017407445,0.12212297,-0.014170633,0.077744566,-0.09333294,0.072061196,-0.0015282445,0.0092819575,0.06717429,0.0747107,0.024086177,0.017199125,-0.11008217,0.05026469,0.065230094,0.055626575,-0.04596744,-0.0142073,-0.0059047937,0.006450062,0.019204848,-0.031703107,0.029537657,0.043993946,0.02910627,0.08564512,0.03669176,0.06719987,0.029903473,0.027233355,-0.09966445,0.043521363,0.01692706,-0.082443714,-0.013797939,0.0068908865,0.018764772,-0.053153686,0.02289272,-0.015471467,0.053517096,-0.07488988,0.09228111,-0.009734975,-0.0755405,-0.053780958,0.012146112,-0.033959337,0.019110138,0.047329955,0.0023967451,-0.009295963,0.12619954,-0.050234422,0.05932629,0.012155811,0.015419928,0.08224961,-0.035467945,-0.031132605,-0.029265758,0.013205038,0.02906079,0.077003516,0.0182075,0.011127155,0.04347273,-0.08999605,-0.010159307,-0.048362885,0.0153463045,0.08999535,-0.056256164,-0.0112519665,0.0068884003,0.026493298,-0.04213377,0.013209074,0.049637113,-2.944592e-08,0.049472257,-0.010268119,-0.0025100312,-0.06352064,5.346029e-05,0.021232797,0.009321837,0.024586929,-0.03444392,-0.07523152,-0.065934315,0.10623226,-0.060760498,0.084480524,0.039119665,-0.024192154,-0.01099653,0.024124688,0.0063484143,0.004025917,-0.044878546,0.021920264,-0.06272595,0.02631175,0.0006730468,-0.066554844,0.025208045,0.01489849,0.036217295,0.038620755,0.024885062,0.044477955,-0.008859994,-0.05294441,-0.050074797,0.0080631105,-0.013619499,-0.061555468,-0.02605668,0.011742014,0.010120218,-0.00809572,-0.06932341,-0.043153472,-0.094477095,-0.07275777,0.012784395,0.0439722,-0.0037997302,-0.025216602,0.064896144,-0.024166593,0.007885081,-0.028516,-0.10250933,-0.07287221,0.010290996,0.0018674482,-0.018359985,-0.11080658,-0.05472404,-0.028465811,0.121732466,-0.04131722 +2.6.1.102,A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis. ,384,1.0,-0.04533552,-0.07299311,-0.06304175,-0.10133908,-0.017207833,-0.030725295,0.03750978,0.026162418,0.051643293,0.12306723,0.0007259046,-0.014997491,-0.06219317,0.032471854,-0.07481588,0.06310837,-0.0046065073,-0.01019683,0.052476283,0.034053016,0.10684041,-0.004159312,0.00047283107,-0.046791468,0.026159702,0.103751525,0.064328484,-0.016486024,-0.034641504,-0.06108829,-0.06557889,-0.056939185,0.070206866,-0.0796588,0.08898603,0.0655689,-0.02349759,0.07658962,-0.026035205,-0.02294745,0.014516408,-0.016310401,0.014453207,0.032686274,-0.084613726,0.012503615,0.019481488,0.07424834,0.05662588,-0.1304827,-0.011252794,-0.06329728,-0.075118385,-0.0134956,-0.0012886807,0.0005962389,0.01157072,0.011558064,-0.05556668,-0.0022937167,0.014428342,0.027964566,0.059172485,-0.034209598,0.053884048,-0.048941523,0.046624985,-0.03785884,-0.021524768,-0.04872286,-0.037246104,-0.031599,0.08219092,-0.039769966,-0.012865351,0.031616043,0.024359768,-0.06936471,0.051468953,-0.058649037,0.013701327,0.010102368,-0.008030128,0.111839294,-0.020082464,0.010725387,0.033203933,-0.027003862,0.10320986,-0.004361056,-0.07201649,-0.0230983,-0.02972942,-0.017389739,-0.12241008,-0.0007343157,-0.0016360176,0.048721842,0.08092248,-0.022689767,0.019161394,0.013715145,-0.022499247,-0.078839615,-0.083479784,0.020826124,-0.023384433,0.039437376,0.051080465,-0.010459419,-0.038495358,0.10146244,-0.016037513,0.078219965,-0.075065985,-0.040939238,0.07730569,-0.048268672,-0.05013195,0.008323913,-0.07273352,-0.055630516,0.029184511,0.08523086,-0.00044444372,0.018998805,-0.026798077,1.4703448e-33,0.022242663,0.03487127,0.026935438,-0.049308285,-0.03606177,0.011252735,-0.071676865,-0.055673264,-0.05323809,0.00076887535,-0.076121345,-0.09936545,0.011793962,0.056001477,-0.005685529,0.0019815299,-0.0070231855,0.005935886,0.06798386,-0.020375764,0.010776996,0.102786824,-0.03891885,-0.032222167,0.0911371,0.1003514,-0.0016110592,0.019843038,0.05315326,-0.0021505372,0.030626154,-0.051559124,-0.045549624,0.0030652261,0.036441144,-0.00080574915,-0.082575805,0.009077032,0.010600839,-0.00925833,-0.0047057243,0.010646633,0.0057831504,-0.014782034,-0.014781479,-0.028909925,-0.030968249,0.107095405,0.01654646,0.05850232,-0.008041609,-0.045975864,0.04085097,-0.016422654,-0.11077272,-0.016126063,-0.060316954,-0.04252441,0.06740407,0.05038253,0.06579747,0.06399803,-0.091962725,-0.027470754,0.020303221,-0.042820282,-0.0011663513,-0.01615891,0.106941946,0.01025927,-0.043623824,-0.035349462,0.0045153475,0.06292924,-0.0058081965,-0.06670741,0.017476128,0.037394058,0.068247974,-0.015885657,0.030973112,-0.065083995,-0.020327086,-0.06915425,-0.040179737,0.100088105,-0.05066402,-0.06753839,-0.043587875,0.07906744,-0.0055406145,-0.12266154,-0.08928118,0.076911844,-0.039209895,-3.287261e-33,0.013177601,-0.09453415,0.08484646,-0.058405295,0.004664773,0.014299079,0.043698538,0.031901628,0.023035645,-0.023510925,0.013396184,-0.0089854635,-0.012445662,0.013082618,0.003900316,0.060865767,-0.031161241,0.04706495,0.004702248,0.016923789,-0.067608014,0.06260945,-0.023091584,0.059225067,0.020029332,0.012342313,0.050252546,0.05479449,-0.02901447,0.020216575,0.041590977,0.039865732,-0.027510397,-0.016403848,-0.06378648,-0.054116644,-0.062327374,-0.0070448266,0.01459785,0.03313857,-0.020520505,0.08571818,0.033882655,-0.021663763,-0.05205807,0.072092764,-0.08620685,0.01689327,0.01763494,-0.05514677,0.021883002,-0.008291226,0.06886813,-0.01263656,0.020526916,0.025072152,0.02886808,0.04399187,-0.0026069316,-0.054529335,-0.05842105,-0.10842782,0.07707939,-0.0110954335,0.0442957,0.08222938,0.05257254,0.0111572305,0.0012627351,-0.020484447,0.033072237,0.026616449,-0.056241937,0.0060582776,-0.07291374,-0.016508799,-0.049741786,0.017309416,0.0747533,0.013941583,0.014757913,0.0006773017,-0.0032330637,-0.033529516,-0.0139730545,-0.032926038,0.10016023,0.09413656,0.0050540054,0.07785889,0.0069713565,0.05209042,-0.033552133,0.039007302,0.14644831,-3.73769e-08,0.05376833,-0.064407684,0.02322154,0.010384168,0.0033552458,-0.00902377,0.009202511,0.030282442,0.08020918,0.0042204056,0.03175819,0.11912255,0.018675594,-0.023429094,-0.028796963,0.042805843,-0.020416267,-0.024704456,-0.011698951,0.013685254,-0.09122307,-0.0019310589,-0.13321479,-0.00061152485,0.059918325,-0.051211655,0.039957125,-0.018139202,-0.03324845,0.0017319677,0.01886779,0.040422544,-0.04721935,-0.09878505,-0.01869729,0.034970194,-0.009744439,-0.06659506,-0.019415725,0.005716993,0.075601436,-0.02182237,0.04347805,0.001042567,-0.02286863,0.025750844,-0.09359578,0.025252165,-0.049414676,0.022089751,0.06730044,0.021438867,-0.077293426,-0.094340295,-0.12860966,-0.0025145174,-0.02416282,-0.054607406,-0.06740501,-0.01612937,0.043668073,-0.022636827,0.10928077,-0.05453765 +2.6.99.3,"The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase.",384,1.0,-0.0125379795,0.0064846682,-0.054190647,-0.014837913,0.012938631,0.038750052,-0.064290136,0.03622215,0.055277053,0.0014284279,-0.065773286,-0.040057458,-0.0010697137,0.024560375,-0.043566573,-0.0019878333,-0.059227962,0.034622718,0.038054444,-0.039588083,0.08041,0.047917668,0.057481557,0.032225326,0.032996044,0.019541064,0.049127392,0.033273965,-0.06226927,-0.0009503842,0.0051218076,-0.07053653,0.06338127,-0.029069921,0.09159288,0.06309535,-0.03310852,0.005477914,0.074466914,0.04904984,-0.034382693,-0.022966066,-0.01695156,0.08288721,-0.04591431,0.035378695,-0.006785533,0.05234642,-0.017770959,-0.061049234,-0.004370791,-0.058448564,-0.0413216,0.048244655,0.065405704,0.079371005,-0.04221231,0.028844256,-0.023619948,-0.06408852,0.07313822,0.035913575,0.00013866283,0.01385527,-0.035874568,-0.037192527,0.0059648696,-0.053272683,0.02036738,-0.0845814,-0.05664476,-0.08794284,-0.009087353,0.021162909,0.0054767597,-0.016728869,-0.009932044,-0.06860663,-0.038727198,-0.0438215,0.13989082,-0.013058854,-0.006544717,0.087028444,0.047801,-0.0024967217,0.05458975,-0.008507322,0.018864099,0.03434928,0.05329122,-0.043722525,-0.036455076,-0.046881218,-0.07347062,-0.027163673,-0.026591245,0.09122696,0.05773309,-0.035958145,0.003549494,0.09570391,-0.048327006,-0.034867797,-0.013096048,-0.012610626,0.018422278,0.09880558,-0.021970028,-0.039503556,0.015347687,-0.028366454,-0.01823982,0.03937899,-0.011101863,0.08573775,0.08271229,-0.035896625,-0.047332417,-0.014617369,0.038256135,-0.042731617,0.0059612887,0.0817989,-0.028003614,0.06590566,-0.10624962,3.933661e-34,0.017236952,0.035810668,0.014380182,-0.033969987,0.023911264,-0.005923431,-0.058332328,-0.00446299,-0.02202814,-0.01335152,-0.109572224,-0.08871924,0.048829213,0.06501668,-0.0008155212,-0.03368365,-0.025711617,0.024229685,0.07693948,-0.0155201815,0.03913708,0.022252014,-0.037741948,0.010186531,0.015334656,0.077298,-0.041401695,0.091491714,0.09784274,-0.022078864,-0.083821766,-0.10489708,-0.036191177,0.0070611336,0.042900078,-0.054653745,-0.05219735,-0.030996315,0.037340794,0.03773733,-0.06454062,-0.03346579,0.032438666,-0.04227539,0.025547605,-0.024653664,-0.09226831,0.05650744,0.07130332,0.06053531,0.08422841,-0.05731628,0.08108493,-0.010442425,-0.083520025,0.028540319,-0.022496277,-0.006197368,0.006322193,0.06695598,-0.041923463,0.07951835,-0.015773823,-0.011932956,0.055164292,0.026628919,-0.03671024,-0.049771015,-0.04933428,0.053599004,-0.11861318,-0.04105262,0.079912715,-0.034326762,0.050286364,0.017159339,-0.104469046,0.02541837,0.064186074,0.0055969944,-0.04681457,-0.037236214,-0.0728834,0.0025465465,0.0043740054,0.018277928,-0.035961457,-0.08904172,-0.008945637,0.09195119,-0.037613075,-0.113995425,-0.07604141,0.060526323,0.028104676,-3.2037074e-33,0.07871394,-0.051664032,0.038616493,-0.083642334,-0.062755436,0.08542587,-0.04367073,-0.048114184,0.0489235,-0.03408542,0.044132765,-0.018646756,-0.031142827,0.032094095,-0.015800923,-0.027490383,-0.025163872,0.06663804,-0.046124708,0.03582341,0.04922291,0.024048313,-0.00135837,0.046594284,0.099865146,-0.009256687,0.042919103,0.08155845,0.067526825,0.022077657,0.011880225,-0.03929736,-0.005946017,-0.049910415,-0.05738827,0.124571875,-0.07492217,0.001284591,0.01817233,0.026772754,0.0032167376,0.0071091526,0.00043724463,0.09900362,0.056592114,0.05499081,-0.061393913,0.067754924,0.019686999,-0.05868508,0.004683336,0.037697356,0.029048074,0.014034965,0.009568437,0.036300834,-0.0036723074,0.02153768,0.025178866,-0.022436937,-0.011956995,-0.05884121,0.034409456,-0.0029819563,0.07243166,-0.059396457,-0.061016418,0.074719414,0.044476263,0.008142586,0.058960248,-0.016579047,-0.05077862,0.034125112,-0.076526314,-0.0625523,-0.07742083,0.014148182,0.066878274,0.050692108,0.016424976,0.0059593725,0.0087458845,0.0013251428,-0.06926229,-0.09338344,0.057196863,0.083015814,-0.014734175,0.013094793,-0.02089422,0.02204006,-0.021447554,0.023535453,0.020897169,-3.0795917e-08,0.06621497,-0.07192865,0.049060762,-0.0781215,0.021370454,-0.049814828,0.0055482476,0.019387433,0.00089002325,-0.03442622,-0.03936419,0.052765235,0.042369258,-0.015824337,3.3790704e-05,0.023887618,-0.059262283,-0.0039944863,-0.014661857,0.030502992,-0.05153132,-0.05300766,-0.15898292,-0.00866297,0.029721914,-0.11737092,0.07587007,0.028493265,-0.065206885,0.061302453,0.051271424,-0.011448288,-0.027071515,-0.017478228,-0.031005453,-0.012135818,-0.087383956,-0.074284814,0.02015457,-0.054445084,-0.026001953,-0.029858697,-0.053487897,0.037102494,-0.025582362,0.0050301305,-0.013354239,0.007567947,-0.030082116,0.004797518,0.029383894,-0.028332839,-0.03002796,-0.05814055,-0.04646522,0.015487327,-0.017329523,-0.058703747,-0.028779889,-0.062756255,-0.016979769,0.033521295,0.22392583,-0.0586161 +2.7.7.86,Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.,384,1.0,-0.1345496,-0.023971807,0.008032861,-0.012034197,0.030237084,-0.024527662,0.08753704,0.022225874,0.072944604,0.07200248,-0.043547865,0.032094408,0.026065607,-0.010691941,-0.019453628,0.053808957,-0.08842016,0.017457964,0.0034390287,-0.06428403,0.0062935227,0.025459358,0.040216327,0.051607054,-0.03429727,0.027964594,0.03152507,0.06872783,0.015630731,0.034715164,-0.057161674,0.021934276,0.0035273852,0.006390661,-0.086409375,0.018891567,-0.057062145,0.014102738,0.0048286864,-0.010094539,0.07472047,-0.077258,0.009090047,0.030350605,0.0489456,0.00631145,-0.056556396,0.02217129,-0.0028562981,-0.004580985,0.026804099,0.0068874448,-0.038615834,0.035538804,0.008788075,-0.013741995,-0.1041894,0.005076777,0.08170441,-0.015550763,0.047108803,-0.06951365,-0.0092936,0.06891147,0.021012094,0.026515177,0.02052897,-0.012602765,-0.05946978,-0.036616392,0.018106254,0.03690212,-0.09423467,-0.019942787,0.035117783,0.054623056,-0.014172764,-0.06434686,-0.010653174,-0.022804836,0.0714796,0.031539597,0.16284524,0.067373775,-0.004492464,-0.045610588,0.07859874,0.053871013,-0.082785174,0.021304006,-0.060614955,0.0093164025,0.006041635,0.03284937,-0.05504399,0.019333705,0.017096601,-0.046199244,-0.026375458,0.042256434,-0.028907726,0.025281195,-0.061671056,-0.015141128,-0.06812519,0.04882341,-0.06288601,-0.0026311413,-0.021690477,0.07656109,-0.054764744,-0.037602715,-0.062309034,-0.05000582,-0.036055464,0.062040914,-0.0619857,0.05637467,0.11397119,0.043147326,-0.02127138,-0.014891771,-0.0982865,0.075947054,-0.066880316,0.012922013,0.034458302,-2.6529403e-33,0.0052262316,0.01591256,0.020809619,0.059194323,-0.047008786,0.08966471,-0.029289527,-0.0859024,-0.03955496,-0.108317696,-0.022535648,-0.0033306372,0.07364998,-0.025880465,-0.004789507,-0.011841118,-0.061533544,-0.008407325,0.058309693,-0.018655052,-0.029802194,0.041032374,-0.065108016,0.0046609766,-0.008607178,0.07930109,-0.013415716,-0.037722047,0.06446085,0.01181749,-0.016712409,0.019655354,-0.02599222,-0.0003007712,0.033825293,0.0017260019,-0.0049993536,-0.050858088,0.031712595,0.07451555,0.0025789612,-0.097051166,0.0054135025,-0.02057255,0.07520157,-0.060416795,-0.028021106,0.02774401,-0.067746274,0.056617968,0.033920426,0.038087547,0.0060015316,-0.013545278,-0.11532695,-0.023281822,-0.040291313,-0.03267795,-0.06181148,0.052770548,0.052408475,-0.0059892056,0.019030191,0.11562816,-0.09632527,0.023242127,-0.14668861,-0.07700691,0.07611584,0.14205539,0.02414897,-0.034543533,0.10955362,0.000811696,0.016412029,0.0668017,0.021986468,0.040857606,-0.06947942,0.08858046,-0.03183351,-0.06900071,0.020337582,-0.0013608227,-0.027274827,-0.06736993,-0.025420029,-0.022852644,-0.021121472,-0.04563984,0.045470808,-0.02060236,-0.005921406,0.06427714,-0.01691468,-1.1738248e-33,0.031044608,-0.033476967,0.064571284,-0.04001489,-0.037066806,0.02119675,0.03785081,-0.1092442,0.04759827,0.07030866,0.11090069,0.04744041,0.0072023263,-0.00096927973,0.01874368,-0.035670705,0.01903187,0.04949382,-0.040125564,0.020823348,0.08008364,-0.014423748,0.011549409,0.060385104,0.051993705,0.0060511725,0.0039511425,-0.037097853,0.025544,0.093556665,-0.051425952,-0.044098984,0.033843007,0.020069186,0.06584886,0.021306198,0.012780772,-0.078867875,-0.089570984,-0.023115596,-0.05321575,0.008124766,0.059441686,0.04291106,0.052768968,0.09841374,0.079706125,0.11221631,0.0028657378,-0.016779639,-0.043199245,-0.012501127,-0.061602283,-0.012107035,-0.044662528,-0.04064314,0.039540082,0.022785928,-0.026822777,0.033110302,0.0068923947,0.008797421,0.05509197,-0.026385965,0.038351428,0.0059441384,0.05212738,-0.10858022,0.0044615134,0.01489079,0.031082919,0.02523033,0.007434869,-0.06757798,-0.034711,0.039697234,0.059469055,-0.033889487,-0.07662115,0.013180473,-0.061211787,-0.03242495,0.049467977,0.002952946,-0.07358114,-0.09381868,0.027552502,0.055900156,-0.016164145,0.056347016,-0.04233979,0.04303185,-0.06226139,0.00150396,-0.07695801,-3.224712e-08,0.09279818,-0.038454723,-0.019093625,-0.06012737,0.028041184,0.0059871357,-0.030682454,-0.057260007,0.09917297,-0.012957241,0.008353967,-0.072248824,0.045310527,0.030718265,0.11459161,0.014328453,0.023858616,-0.033863757,-0.014019362,-0.05450293,-0.108743206,-0.06946008,-0.02141376,0.0032810345,-0.07996825,-0.029552333,-0.021614758,0.0088686645,0.011651225,-0.08058052,0.07179279,0.034522012,-0.018616488,-0.04601479,-0.11054419,0.06539873,0.04463397,0.0025718592,-0.025766658,0.02721669,0.011376559,0.0031154852,0.004390468,-0.0043919277,-0.025944445,-0.003744938,0.021239825,-0.045512352,-0.048095707,-0.033364743,-0.06996647,0.009351262,-0.046627745,-0.022780597,-0.030585999,-0.010197991,-0.07437064,-0.1044125,0.033284917,-0.10338591,-0.08059209,0.02771828,0.06813721,-0.054005027 +2.7.7.87,"The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg [6]. ",384,0.99999994,-0.10841674,-0.05158047,-0.113476925,-0.041058168,-0.037265692,-0.03163253,-0.04551563,0.03664895,0.002965488,0.043936916,0.043818474,-0.04595599,-0.06382245,-0.04009493,-0.08331059,0.049569882,-0.0716509,-0.015148773,0.06685217,-0.029227473,-0.024935644,0.08929603,-0.0015622971,-0.012883831,0.039371025,0.008453169,0.017573154,-0.075057566,0.03599189,-0.06557774,-0.047841143,-0.014024384,0.068389274,-0.05381526,0.021241242,0.06072178,-0.1615134,0.0006573,0.13721512,0.019411393,-0.0019215043,0.01416316,0.0042310217,-0.05915596,-0.052211072,-0.075764425,-0.011608454,0.07771411,0.030645212,0.09238353,0.0013165998,-0.036798738,-0.08191405,0.022378193,0.017515535,0.07565566,-0.10979271,-0.010643359,0.005254481,0.07098998,0.12570515,0.067984454,-0.0017637333,-0.03738423,0.05471987,-0.042806976,0.010082249,0.05982986,0.08754281,-0.0014964235,-0.005149472,0.019102013,0.018267136,0.012876611,-0.045479707,0.017358145,0.016677624,-0.01527658,-0.005442471,-0.010913729,-0.035458677,-0.0027950613,0.072924584,0.08669992,0.04767951,-0.011285242,-0.0039407443,0.062890075,0.030802166,0.052256018,0.09687105,0.00457252,-0.037716445,-0.034712087,-0.028391697,0.0472868,-0.012375137,0.09197114,-0.023361742,-0.019232206,0.008099727,-0.017054042,-0.019038502,-0.09761677,-0.022453094,0.020622155,0.015944159,-0.027357552,0.03657757,0.019006263,-0.023739826,0.038334247,-0.0017656547,-0.011767538,-0.056597248,0.017459039,0.004058891,-0.048571397,0.036723454,-0.0043676547,-0.021445598,0.02231394,0.022672562,0.011414943,0.0006230304,0.0096766,-0.026187446,1.9681781e-33,-0.017188614,-0.012639721,0.003198159,-0.017205272,0.07483516,-0.009317058,-0.020435963,0.0063044555,-0.096330106,-0.022684675,-0.078753375,-0.06469952,0.019871261,-0.012571371,0.043915424,-0.027552696,-0.030562742,-0.0067203813,0.038289946,-0.042365216,0.008270731,0.08892279,-0.060756654,0.014992576,-0.031688623,0.07746097,-0.017306453,0.053458612,0.048721623,-0.009307621,-1.2739494e-05,-0.009082807,-0.020869486,0.0071389824,0.0930993,-0.06459146,-0.060223274,-0.024330711,-0.086346455,0.021725817,0.03574264,0.011999205,-0.050683774,-0.02274063,-0.04348103,-0.04327939,-0.014579877,0.06599613,0.017173072,0.02201133,0.044666395,-0.041879058,-0.0040291646,-0.011267,-0.028977148,0.011124649,0.00082616066,0.003248707,0.10830965,0.046795,0.020917693,-0.037906576,0.008739086,0.02171503,-0.036435157,-0.03563968,-0.056750406,-0.034616314,-0.0072136745,-0.001600446,-0.02054766,-0.052895166,0.009004364,-0.011142355,0.043675635,-0.01973135,-0.08194619,-0.007178726,-0.036776215,-0.0072291144,0.057482004,-0.013535022,0.03125942,-0.054664187,-0.05200974,0.015992748,-0.017791726,-0.03714682,0.05400866,0.0992421,0.019410063,-0.038944762,-0.1611526,-0.0024241745,0.057175,-3.2653205e-33,0.106298946,-0.07920267,0.05617745,-0.036362264,-0.1402887,0.057223354,0.007413671,-0.12200897,-0.02339964,-0.04534623,0.10914768,0.0059086042,-0.037032012,-0.016292883,0.030889202,-0.04141972,0.045414332,0.020491358,-0.02427911,-0.07902052,0.0034582338,-0.021084795,-0.042982962,0.014331209,-0.013351531,-0.010566154,0.013598499,0.045950327,0.002700722,0.1124845,-0.012599198,-0.026306976,0.024522293,0.07299297,-0.065636106,0.042515453,0.038366105,-0.0045247343,0.030925322,-0.033784606,0.06256978,-0.03458294,0.03270802,0.06775194,-0.02210645,-0.011663496,-0.04739614,-0.031661306,-0.08762416,-0.054258954,0.12499553,0.039936554,0.06439546,0.0051865536,0.048052307,0.052660223,-0.04351139,-0.070528805,0.08680931,-0.044809084,-0.016586524,-0.06628318,-0.010044189,-0.040607713,0.097962014,0.031429444,-0.10419055,0.1367467,0.042266827,-0.040202033,-0.020589795,0.0135757085,-0.045633115,-0.026655313,-0.032538116,-0.045157865,0.036316227,-0.023541043,0.03178093,-0.08594665,-0.046216838,-0.04748314,0.011274661,-0.056651853,-0.041012637,-0.013865025,0.08891755,0.12136602,-0.043884803,0.09312172,0.03356323,0.031205794,-0.010459947,0.031730607,0.06713558,-3.763764e-08,-0.034807786,-0.102850534,-0.032887835,-0.016907394,0.051478453,0.02176947,-0.022183962,0.05745587,0.012896343,0.04629988,-0.0008876015,0.035129935,-0.0073218984,0.06669401,0.025102615,0.0517935,-0.07094904,0.0014791021,-0.011092515,-0.01784609,-0.1037501,0.050856277,-0.11562316,-0.019626243,0.009740276,-0.017517377,0.02882756,0.029253833,0.010293401,0.047670875,-0.020167353,0.001021824,-0.026440507,-0.08006967,-0.005731058,0.07638414,0.064259864,-0.10265387,-0.030385634,-0.030294556,0.01566753,0.0821496,-0.080102496,0.004360985,-0.059638053,-0.01942558,0.004873041,0.09467122,-0.043417804,0.032273084,0.033317253,0.033405475,0.029426187,-0.017436013,-0.035441115,0.03668184,0.012463799,-0.049427703,-0.084653266,0.07789885,0.01576119,-0.037380744,0.14342032,0.009633835 +2.7.8.39,"Requires Mg2+ or Mn2+ for activity. The enzyme is involved in biosynthesis of archaetidyl-myo-inositol, a compound essential for glycolipid biosynthesis in archaea. ",384,1.0,-0.059253354,-0.04164024,-0.049319606,0.015182757,0.06966313,-0.08533487,-0.027159879,0.029740792,0.024116574,-0.00019065292,-0.01890296,-0.011449204,0.011799928,-0.024593372,-0.070024736,0.04818359,-0.017211078,0.04148435,-0.025422983,-0.0032456403,0.11387163,0.045180343,-0.023101205,-0.014090207,-0.0037279045,0.029899823,0.009897599,-0.03390924,0.0126427,-0.03376934,-0.0459502,0.015336896,0.121329434,-0.10288651,0.038532216,0.17462209,-0.039562844,-0.010342617,0.01621517,-0.06840067,0.035187557,-0.034772478,0.12514058,-0.03888081,-0.022290988,-0.054009374,0.048595168,-0.064877555,0.031206068,0.095454656,-0.06785234,-0.0016729533,-0.07096879,-0.008627823,0.01937811,0.07207109,-0.11218761,-0.018507352,-0.021091793,-0.025680216,0.053455684,0.01537134,-0.028291095,0.049086165,-0.003604444,-0.019181598,0.036025457,-0.037625723,0.014061193,5.1905836e-06,-0.007613089,-0.03151802,-0.031213857,0.045711707,-0.036184378,0.08767899,0.054488495,-0.028018005,0.05097994,-0.031752866,0.018813305,-0.004834067,0.079637796,0.014835057,0.053885795,0.044624582,0.08250261,0.051404566,0.043555286,0.053347364,0.08759063,-0.015000035,0.0058034733,-0.02593563,0.0015771597,0.012368467,0.012522611,-0.0033774748,-0.066736616,0.0049503604,0.0003006282,0.044493653,-0.03178166,-0.05080349,-0.040381916,-0.02567345,-0.029624682,0.04333989,0.04067441,0.093718134,0.056017093,-0.04136602,0.050687876,0.054806307,0.025575643,0.08030106,0.04534021,-0.114539154,-0.052165903,0.015147947,-0.0063061304,-0.012411051,-0.0077065635,0.027184607,-0.09914275,0.08068879,-0.022635864,2.6094255e-33,0.047768515,0.0019595963,-0.00021685378,-0.015749931,0.005352822,-0.007463244,-0.0591454,-0.05420413,-0.011511633,-0.040850107,-0.052740823,-0.06854665,0.026224077,0.060689922,-0.055389903,0.023855979,0.016131688,-0.028797116,0.11189785,0.039124474,-0.03710345,0.07683134,-0.025303682,-0.024498627,0.043280065,0.07683879,0.025460688,-0.082894064,0.03400427,0.008477457,0.057895355,-0.15344141,-0.118976146,-0.0037480514,0.08124536,-0.016216068,-0.0029965825,-0.075534254,-0.05867167,0.020217083,-0.07927963,0.040571805,-0.067820616,0.008928815,0.0334749,-0.051460404,0.0157689,0.05874591,-0.033261664,0.046339568,0.028228838,0.03312765,0.03415924,0.0035626215,-0.10126537,0.020393176,-0.009805445,0.018166924,0.07199334,0.056722533,-0.04347529,0.023578683,0.07718573,0.09769942,0.03856588,-0.0007498853,-0.069127545,-0.025440505,-0.0059762984,0.03310938,0.024886537,-0.14312862,0.033411615,0.038165838,-0.04564608,-0.03200059,-0.0056968536,-0.056860626,-0.021654114,0.016923467,-0.026198078,-0.04325815,0.010572248,0.011107612,-0.043502,0.061997734,0.0041972464,-0.054208424,-0.0012543908,-0.0050266795,0.044638388,0.0032284863,-0.05868177,0.051465657,-0.024965703,-5.105908e-33,0.044268258,-0.09037214,0.09740202,-0.09313026,-0.109562494,0.040315706,-0.029726949,-0.13844599,0.055636972,0.012369691,0.054861624,0.0048398473,0.0069787335,-0.067409895,-0.011930029,-0.06418392,-0.0050292183,0.055814877,0.02168078,0.03443787,0.04748329,0.079919994,0.015292053,0.03652024,0.020474061,0.012045024,-0.007762107,0.0044070296,-0.02973594,0.040209707,0.013913068,0.05108818,-0.058228992,-0.11034838,-0.050946914,0.029029801,-0.030725084,-0.044407528,-0.018424533,-0.0021734608,-0.011331003,0.08994708,0.047378473,0.0420664,-0.010403981,-0.032882735,-0.068003796,0.056096435,0.028470114,-0.057934977,-0.039863832,-0.011159784,-0.01130809,-0.019678904,0.04213387,-0.01838696,0.010512743,0.030955095,0.0064074127,-0.036102433,-0.050578278,-0.059872907,0.009508535,-0.070965596,0.04979487,0.09711836,-0.010089647,0.02554396,-0.019049352,0.02989802,0.02268339,-0.027523505,0.050930385,0.11165925,0.03932406,0.014205448,-0.0044132993,-0.06342102,0.06688093,-0.10268172,-0.06515416,0.053449485,0.0257614,-0.07582714,-0.044955935,-0.13802606,0.06350394,0.12669407,-0.034024898,0.0051673627,-0.0013468611,-0.051948268,-0.07407288,-0.00031389293,-0.012568526,-3.1740843e-08,0.0183462,-0.050511155,0.050810598,-0.09277638,-0.047524612,0.038377754,-0.007346215,-0.012699495,0.07422148,-0.016536018,0.025044335,0.013238905,0.037043337,-0.030962002,0.015266281,0.088987865,-0.0011363258,-0.00081444863,-0.062293302,-0.07158623,-0.037782367,-0.059544217,-0.056617822,0.040511597,0.055993453,-0.035164233,0.0127566,0.065082334,-0.024976071,0.0091846185,-0.026591666,0.0035410505,0.010074909,-0.019752106,-0.052443177,0.07417899,-0.008789997,-0.046790197,-0.047260057,-0.080693185,-0.09341971,-0.05337223,0.046843875,-0.016118888,-0.059648238,0.017277118,-0.005050817,0.05938332,-0.009491794,0.033703834,0.00069720356,-0.063545294,0.032138243,-0.075115904,-0.03191123,0.01126292,0.019248445,-0.032807253,-0.0033145119,-0.031482756,0.05143089,0.02444058,0.06004447,-0.12039116 +2.7.8.40,"The enzyme catalyses a step in the assembly of the repeating-unit of the O-antigen of the Gram-negative bacterium Aeromonas hydrophila AH-3. The enzyme shows no activity with UDP-N-acetyl-alpha-D-glucosamine (cf. EC 2.7.8.33, UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase). ",384,1.0,-0.032139417,-0.06957825,-0.058861088,-0.05298803,-0.0038419059,0.04282483,-0.00576307,-0.009499611,0.028933577,-0.023639845,0.06476582,-0.010707718,-0.050117828,0.046847913,-0.085288905,0.07601837,-0.02913472,-0.032901924,-0.007906591,-0.045266226,0.06933717,0.0698329,-0.047212474,-0.009198196,0.05311629,0.040108394,0.037936352,-0.019591846,0.034232926,-0.101500876,-0.036377665,-0.079556085,0.10299359,-0.07269558,0.12407848,0.026866408,0.047125217,-0.03596329,0.08116186,0.02830152,0.029132565,0.007986053,-0.046817694,-0.032033358,-0.07479083,0.010719215,0.049038935,0.027582087,0.09179994,-0.012966397,0.033313405,-0.05784634,0.04190512,0.06273971,0.022028219,0.013040572,-0.043925174,-0.045111146,-0.049365424,-0.004958545,-0.003939366,0.038807563,0.018848335,-0.011452136,0.07613693,-0.056413196,0.055735394,-0.06541431,-0.034078714,0.0005211392,-0.090512164,-0.046311557,0.05507696,0.022280533,-0.025147611,0.026292868,-0.029147457,-0.020309096,0.10028014,0.02615864,0.035374906,-0.02755312,0.008894735,0.14619194,-0.00061630184,-0.057080712,-0.03981788,0.028334333,0.072820894,-0.0018023526,-0.09239651,-0.11531142,0.03593899,-0.07815235,-0.0035547088,-0.01570701,0.044924136,0.034161232,0.020045176,0.0036908076,-0.041090958,0.015431791,0.022654569,-0.12970597,-0.08673859,0.008983252,-0.05702879,0.09611439,0.09576321,-0.018275952,-0.060816497,-0.02879874,0.044775378,0.04888654,-0.08609692,0.00062610174,0.0049947333,-0.070068546,-0.12391651,-0.017886184,0.02537547,-0.06312572,0.059363723,0.05981728,-0.031922907,0.03755794,-0.05347922,1.4703604e-33,0.0738355,0.04725325,-0.015600485,-0.064075366,-0.00014958516,-0.023768496,-0.029122788,0.01248128,-0.012502937,-0.010358018,-0.06434006,-0.041035622,0.052821163,0.05987472,0.0017851734,0.04708896,-0.022192655,0.0012093447,0.0013167149,-0.0020581798,-0.004496882,0.046454996,-0.050159715,-0.025194053,-0.008205869,0.048420504,-0.049660012,-0.0038590317,0.029929418,3.1313186e-05,0.06606614,-0.041401498,-0.13654038,0.056560937,0.0715736,-0.024874156,-0.010092059,-0.0762203,0.024992192,0.010666216,0.014146413,0.0406887,0.004921512,-0.055521995,0.053332906,0.014199284,-0.023808518,0.01945618,0.01208875,0.09547422,0.050506417,-0.021733595,0.06052293,-0.06840319,-0.04287376,-0.03757472,-0.081867225,-0.021393044,0.019502068,0.050611224,-0.04254975,0.010648419,-0.06506631,-0.010969582,-0.087588124,-0.018094376,-0.008928607,-0.015498028,0.07157784,0.052585907,-0.009480345,0.0036310472,-0.016740482,0.061070263,-0.039978895,-0.08886942,0.027148098,0.015773362,0.039117157,0.0024849812,0.0071511716,-0.0078023397,0.07240794,-0.046714876,-0.03328354,0.012433382,0.050533056,-0.026652792,-0.040248133,0.0503013,-0.00058765494,-0.07144637,-0.04213129,0.07630015,0.04772393,-3.00491e-33,0.10596456,-0.11354166,0.030723276,-0.11666365,-0.08795121,0.0927295,0.028368933,0.037089836,-0.033633098,0.0002077334,0.053338498,0.06609955,-0.008887267,0.029480133,0.08245962,-0.03735267,-0.0054118345,0.037486598,-0.010092836,-0.03605448,0.058865942,0.04179632,0.0057861614,-0.007762108,0.03376702,0.0072512864,0.024625186,0.07285402,0.05261463,0.08238285,0.01709294,0.04025934,-0.010558529,0.011107023,0.00031898366,-0.009232064,0.07094725,1.2280889e-05,-0.015835382,-0.0070753624,-0.0003543466,0.038705464,-0.010960276,0.0030123515,0.0022747451,0.10948135,-0.042949475,0.0050918213,-0.009476101,-0.05417011,0.04840392,-0.014297348,-0.006211242,-0.021121392,2.4681589e-05,0.048158064,0.029095612,-0.026908519,0.0035316786,-0.050601896,-0.06830545,-0.051771212,0.015396623,-0.012425803,-0.0042784093,0.10563676,0.07790502,0.052186202,0.010317341,-0.02642332,-0.04228884,-0.017753687,0.0681749,0.019777229,-0.014947363,-0.036798894,-0.072240286,-0.028326133,0.048362345,-0.07698621,-0.018596178,-0.0375057,-0.031869974,-0.044283237,0.027906762,-0.061648417,0.04786148,0.15043381,-0.006708176,0.08093952,-0.007437971,0.026847245,-0.04945747,0.058200065,0.104348116,-4.6453998e-08,0.038901314,-0.029354092,0.07719091,-0.027316526,-0.041030776,0.098811395,0.003990676,0.011181052,0.07951082,-0.022681732,0.063757725,0.08093317,-0.011933685,-0.017053308,0.009566626,-0.022994218,-0.05081575,-0.008250393,-0.019617645,-0.017558075,-0.10153768,0.009882566,-0.07347299,0.052170854,-0.032518197,-0.0517399,0.030280394,0.021236476,-0.014283706,-0.057970952,-0.06957642,0.063798256,-0.039987154,-0.08190161,-0.10669272,-0.02477012,0.0030712204,-0.068458706,-0.016539993,0.004754706,0.05319571,0.039935995,-0.026635358,-0.023969792,0.061281707,0.044242628,-0.03022241,-0.036812816,-0.067827575,-0.023214327,0.07142109,-0.028811356,0.009684639,-0.013973295,-0.13112585,-0.041601423,-0.0519013,-0.12883945,-0.04066347,0.023608241,0.002078528,0.0073876916,0.11959767,-0.02394259 +3.1.3.90,The enzyme from the bacterium Enterococcus faecalis also has activity with the sucrose isomer turanose 6'-phosphate (alpha-D-glucopyranosyl-(1->3)-D-fructose 6-phosphate).,384,1.0,-0.025700128,-0.13211216,-0.10852152,0.0063477443,0.034695085,0.0024124,-0.038217917,0.0024677378,0.05056225,0.036504045,0.011010786,0.004018593,-0.086423546,0.058792863,-0.06617748,-0.07946961,-0.03424275,0.0017408032,0.024980878,-0.013499553,0.052593682,0.014726407,-0.021079434,-0.028236529,0.07754852,-0.061942104,0.085622415,-0.010656958,-0.03596111,-0.07423253,-0.062028557,-0.10689523,0.13168363,-0.01927309,0.071374476,0.09066894,0.031077772,-0.03537221,0.11156636,-0.026413307,-0.010271969,-0.07729105,0.036731288,0.054310795,-0.06259573,-0.037013453,-0.03128896,0.046262044,0.079579644,-0.033185665,-0.05604747,-0.021718904,-0.051902015,0.06869069,-0.0018721286,0.0042702425,-0.008045603,-0.0517301,-0.026960885,-0.012550503,0.04997984,0.010304851,0.037628468,0.03696742,-0.017914973,-0.05514021,0.020591581,-0.021723941,-0.03185515,-0.014770178,-0.042447474,-0.021318084,0.04418184,0.010222453,-0.007095734,0.041120682,-0.028525613,-0.03912676,-0.00788696,0.037490405,0.06763658,0.012918685,-0.01730228,0.09254977,0.016686417,-0.040702682,0.038606074,0.032569785,0.042513825,-0.0031759446,0.015516559,-0.05626442,-0.011574138,-0.13712761,-0.029785527,-0.09011693,-0.07640596,-0.018811516,0.033219118,-0.047403373,-0.05723622,0.051398076,0.021248238,-0.052731328,-0.013080026,0.03789192,-0.019521872,0.111917235,0.033262312,0.03069092,-0.050935946,0.015146856,0.021670915,0.057106074,-0.05089002,0.026592953,0.0147368815,-0.13187815,-0.051039875,0.056202102,0.015790964,-0.007442938,0.03958364,0.034489453,-0.064649224,0.036368016,-0.02623374,5.7168607e-35,0.004792063,0.036386896,0.024969203,-0.07417767,0.013863342,-0.00045079252,-0.08194215,-0.013094194,-0.07360894,0.071246065,-0.076258026,-0.05259873,0.080372445,0.06995746,0.014662789,0.06372179,-0.011695635,0.023682265,0.03869756,-0.023315236,0.034774978,0.041539155,-0.031075725,-0.012607356,0.07007419,0.04893474,-0.030075625,0.077395186,0.05729907,-0.03237256,0.12947267,-0.031136926,-0.035969183,0.00045216916,0.098928355,-0.022423727,-0.016451966,-0.006662009,0.0006563819,-0.041001596,0.019698305,0.05974421,0.022010295,-0.0047487817,0.004410851,-0.078975774,-0.0644394,0.06842788,0.090332784,0.042200644,0.058968924,-0.038230035,0.018695204,-0.024674792,0.026591131,-0.0040033967,0.008168486,0.004827383,0.045416884,0.019732349,-0.012852346,-0.01751067,-0.020377265,-0.010834917,-0.0036286323,0.003019475,-0.045027908,-0.0087160645,0.0067929397,0.111973606,-0.15175842,0.017696397,-0.026496978,0.020235255,0.003743647,-0.04427742,-0.04450095,-0.0677132,0.0232564,-0.031133771,0.011481642,-0.09086029,0.012844865,0.022357363,-0.08361793,0.02932379,-0.10036099,0.0078081996,0.0008148367,0.0473327,0.05485046,-0.06362795,-0.17300333,0.06226589,0.031685185,-2.2571306e-33,0.11273589,-0.10033558,0.053077918,-0.10556367,-0.018935518,0.053131808,0.041509546,0.0035722386,0.054717746,-0.00070303906,0.09193722,0.068557546,0.010676825,0.009690267,0.03656003,0.011530714,0.026104199,0.0032669802,0.011212938,-0.014498707,-0.06343079,0.031090643,0.022312576,-0.072895005,0.056495685,0.05128069,0.029806316,0.07618811,-0.07878935,0.038360957,0.0035230739,-0.008862639,0.004389267,-0.037446413,-0.0680267,0.009628058,-0.0145060625,-0.061152924,-0.040283173,-0.038283717,0.022359623,0.076541685,0.051089272,0.040476777,-0.03474147,0.047185402,-0.024019536,0.04547558,-0.039934088,-0.016956063,0.023623746,-0.027298244,-0.01875669,0.018859651,0.05179714,0.059498455,-0.031199588,-0.05315935,-0.052118678,-0.027290873,-0.0033862523,-0.036012433,0.019109216,-0.048032723,0.062608786,-0.024267508,-0.07497088,0.06901244,0.0076350034,-0.020151014,0.020067167,0.0120631745,-0.016075265,0.014702307,-0.021261845,-0.060987018,-0.09360024,-0.018890949,0.02806849,0.024824081,0.00439644,-0.00045610682,-0.05543515,0.0048142103,0.012541819,-0.021987757,0.021391828,0.09805347,0.0063653667,0.07047762,-0.08638376,0.026527883,0.004551944,-0.011571391,0.08281869,-3.3496846e-08,0.017471239,-0.04411647,0.018432917,-0.06255243,-0.0025123789,0.010965046,-0.015071328,0.03273085,-0.00808188,0.02472406,-0.0039631044,0.13112469,-0.0017436474,-0.046568677,0.0028774342,-0.011508548,-0.06474899,0.009372044,-0.0031729497,0.015899243,-0.0675013,-0.00080772885,-0.09046562,0.031817764,0.051373824,-0.0049912105,0.0025973457,0.030825112,-0.07632609,0.03981979,0.028063983,0.004694019,0.028310915,-0.031921726,-0.06912329,0.05750712,-0.05772925,-0.033444934,-0.04880332,0.019247146,0.12523922,0.019279638,-0.08564879,-0.008021474,-0.10049032,0.074407935,-0.0092582535,0.059439756,-0.044846233,-0.021505067,-0.011736078,-0.018969703,-0.08137838,0.031655245,-0.017540848,-0.032638557,0.015167833,-0.084301576,-0.012305427,0.032683052,0.038682148,0.007787621,0.21161096,-0.019309094 +3.5.3.25,"The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.",384,1.0,-0.01909654,0.0056167715,-0.09209462,-0.021635415,-0.05419295,0.028553633,-0.050653957,0.033844553,0.059977405,0.0020175974,-0.10054462,-0.009357452,0.018783934,0.046078227,-0.035994187,-0.008063212,-0.04394564,0.015506832,0.07044846,-0.02018929,0.1054793,0.068102315,0.06639082,0.0030770137,0.05712156,0.0036882737,0.028573398,0.028646456,-0.04210744,0.027913844,0.023656992,-0.041305527,0.077288575,-0.041332383,0.1270948,0.06692976,-0.028000198,0.02950759,0.099676006,0.043119736,-0.038508564,-0.0062153544,-0.029805027,0.11304604,-0.065223366,0.03431293,-0.019258974,0.055104617,-0.009860659,-0.06315269,-0.011246725,-0.05947824,-0.0668333,0.07057222,0.07002547,0.0831387,-0.027745305,0.023265962,-0.032464676,-0.07277686,0.06011554,0.021396728,0.02306504,0.038598776,-0.05724025,-0.020297334,-0.013398581,-0.036730196,0.039855685,-0.08795777,-0.05330283,-0.07702488,0.002629019,0.0068268212,-0.011215799,-0.0476141,0.013503927,-0.04618876,-0.07192536,-0.037578825,0.14322858,0.0015781685,0.0041234354,0.10088674,0.048218116,-0.002255893,0.040578872,-0.025722114,0.015226975,0.042685874,0.040618606,-0.03287351,-0.03494388,-0.06355132,-0.057525326,-0.050457925,-0.054529216,0.047845867,0.032679357,-0.028642362,0.00729546,0.07369743,-0.029094595,-0.012492086,-0.005931648,0.0056893877,0.0005480165,0.060685113,-0.018161777,-0.03717721,-0.0016327635,0.009650097,-0.017615143,0.061812963,-0.023340778,0.07260583,0.078838065,-0.026619747,-0.034891967,-0.033710055,0.01112839,-0.045123037,0.018005563,0.053745285,-0.011154641,0.07219794,-0.07956477,-8.852621e-34,0.011969762,0.044853583,0.016083457,-0.07372052,0.014171026,-0.018218221,-0.0455446,-0.03699185,-0.0028032502,0.017159132,-0.113555945,-0.122619584,0.026337462,0.08935812,0.026028523,0.010361606,-0.030038638,0.055454645,0.0788311,-0.031530287,0.023935119,0.036775164,-0.042476524,-0.011836778,0.0022463023,0.07584061,-0.047934286,0.12742542,0.0909428,-0.035730094,-0.0523214,-0.098964036,-0.017688919,0.014091409,0.04564283,-0.048538126,-0.06518902,-0.04432405,0.040006164,0.026495054,-0.07587054,-0.037866987,0.023255043,-0.024407627,0.038559295,-0.001051824,-0.10424674,0.02841912,0.04441974,0.085637696,0.069203265,-0.04858633,0.076398216,-0.0061871377,-0.108924896,0.045292407,-0.0048709046,0.0014543696,0.024031116,0.03500628,-0.056929275,0.040919855,-0.0048721833,-0.008644991,0.09373078,0.02096253,-0.028621035,-0.021808447,-0.047450777,0.046741724,-0.11864872,-0.040791284,0.032113016,-0.053316236,0.048886996,0.020362953,-0.073660426,0.017768158,0.06037346,-0.017804768,0.0014981987,-0.03732567,-0.09236622,-0.030284278,0.0084285615,0.039488655,-0.03309821,-0.10900419,0.008401773,0.07373692,-0.044107445,-0.11174079,-0.08918665,0.05387606,0.029816687,-2.448997e-33,0.08972815,-0.054457955,0.049721938,-0.048207656,-0.058353666,0.06402342,-0.042731814,-0.029597705,0.030326838,-0.025373776,0.029483749,-0.017358033,-0.07375498,0.018852314,-0.036441147,-0.0032995383,0.00047592135,0.070321515,-0.046555366,0.03808286,0.04735494,0.043449294,-0.023758078,0.027121233,0.0708875,-0.032249715,0.045643426,0.052960284,0.052340273,0.008681406,0.058410563,-0.029408233,-0.006923419,-0.062686056,-0.05118773,0.109022275,-0.07690416,-0.0019104864,0.015331413,0.0108216,0.027484003,0.00888024,0.006410963,0.07993041,0.04694104,0.022623938,-0.075442396,0.03969355,0.03051573,-0.028157523,-0.0023715051,0.03935407,0.061520208,-0.0055480045,0.028082188,0.0074852398,0.023799563,0.01872759,-0.008887504,-0.033405527,0.00525123,-0.058431722,0.04739066,-8.957176e-05,0.081655696,-0.053222306,-0.03842826,0.08100704,0.04720421,-0.001392037,0.020062719,0.0007842752,-0.06417965,0.028306069,-0.082376234,-0.05856757,-0.08189906,-0.01716365,0.053927034,0.068398625,0.010395942,0.0029875773,-0.00060218835,0.004132804,-0.07606733,-0.091350354,0.035443176,0.075348586,0.006127354,0.024131091,-0.004197654,0.013335689,-0.009118025,-0.0074907667,0.008589936,-2.7124406e-08,0.05874163,-0.043851323,0.060607623,-0.04912371,0.008507915,-0.0854624,-0.015010382,-0.007028837,-0.016959047,-0.055871204,-0.03856538,0.045685917,0.033711832,-0.017994737,-0.011356845,0.011338094,-0.09335742,-0.03659748,-0.009096275,0.031339094,-0.054862313,-0.052162893,-0.13276297,0.023098709,0.07820974,-0.1034921,0.0714814,0.036839303,-0.030089019,0.07963943,0.048773836,-0.013719054,-0.042563304,-0.028879227,-0.03312293,-0.036188148,-0.07433356,-0.06533919,0.04047412,-0.055058796,0.0010181686,-0.003864618,-0.02216157,0.040738903,-0.056039464,0.028509747,-0.026119428,0.006852928,-0.042308874,-0.00019458568,0.029992225,-0.013545317,-0.05386681,-0.028751856,-0.042334616,0.024457244,-0.020212334,-0.03025977,-0.043573264,-0.057941165,-0.01204391,0.006583776,0.21094802,-0.06789863 +3.6.3.54,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 3.6.3.4, Cu2+-exporting ATPase, which mainly transports the divalent copper ion.",384,1.0,-0.056398325,-0.056265216,0.013140427,0.00035361876,0.024952153,0.010656144,0.058778137,0.02954814,0.030152403,-0.023293529,0.010482175,-0.023249486,-0.060488895,0.07447945,-0.05543361,-0.15112507,-0.022499116,0.039293833,0.06414881,-0.00490216,0.06520131,-0.0041727456,0.019498494,-0.00014766945,-0.037845895,0.041660883,0.011724915,-0.060616303,-0.01604073,-0.020962786,-0.14488524,-0.030420758,-0.04020244,0.020244043,0.037249256,0.1169655,-0.09502834,0.056910682,-0.008972232,-0.058933035,0.18810241,-0.021692649,0.06805922,0.050363258,-0.029340832,-0.053087857,0.05076384,-0.01175547,-0.025538456,-0.05666131,0.0038326068,-0.03251805,-0.06488834,0.044327833,-0.022971908,0.0292407,-0.019530153,-0.041127164,-0.033574797,-0.04006387,-0.0013557666,0.0016619754,-0.004611909,0.042673863,0.08924758,-0.055946834,0.062534384,0.05826137,-0.0028333536,-0.039218895,-0.036591984,-0.008574116,-0.077514976,-0.01278697,0.031341966,0.022980316,0.022856131,-0.0030713559,0.026658498,-0.037359044,0.037409957,0.013304689,-0.029242313,-0.01826344,0.083914295,0.021473682,0.0034026583,-0.0369005,-0.014671887,-0.0238907,-0.0033252202,0.019264964,0.006282869,-0.0069927676,-0.079721116,0.01596948,-0.0026221578,0.037519824,0.019535258,0.018732397,0.08472984,0.16379564,0.016697228,0.013959605,-0.024663817,0.0012568317,-0.04286589,-0.02608637,-0.029414732,0.089289896,-0.028957333,0.023119459,0.03137049,-0.077958524,0.024729207,0.074066415,-0.06988674,-0.0031922574,-0.014951102,-0.00025345347,-0.04572148,-0.06682563,-0.014958655,0.019262211,-0.01886214,0.0297219,0.0030206454,-3.4516149e-34,-0.05371993,-0.020455083,0.078910775,-0.03380948,0.008492087,0.033905923,-0.083175026,-0.05943836,-0.051640224,-0.0928342,-0.049765747,-0.016078332,0.017814085,0.028544417,0.0031873076,-0.042127866,-0.032929715,0.046432458,0.13906057,-0.04352099,0.048893414,0.032922257,-0.00932003,0.055171788,0.07955641,0.002673203,-0.030668616,0.00866814,0.03670418,-0.001073736,0.027254539,-0.05498341,-0.037688226,-0.006959681,-0.043833416,-0.046433374,-0.078045346,-0.023599528,0.086568885,-0.032877285,-0.095681116,-0.032777224,-0.01189335,0.027838435,0.009919814,-0.072156005,-0.039077688,0.065720536,-0.051911738,0.03197863,0.013888609,-0.09186726,0.08120839,-0.025028905,-0.043366738,-0.016124178,0.02727673,-0.002844287,-0.019184556,0.014366821,0.13682096,0.10053933,-0.03766696,-0.01149591,-0.035235114,0.067676865,-0.112060465,-0.038019236,0.0508585,0.07842054,-0.08197359,0.037270363,-0.001398094,0.0011493041,0.09120653,0.01360353,-0.05152317,-0.037823543,-0.009735624,0.03487913,-0.08685671,-0.04481028,0.0432208,0.057664163,-0.05498875,-0.08579322,-0.039630275,0.009613523,0.06547679,-0.016976276,0.084271096,0.028985549,-0.027549248,0.08740838,0.027591579,-7.1224475e-34,0.06330852,-0.014554148,0.054279763,-0.06340997,-0.05343438,-0.028429085,0.026397152,-0.0009834223,0.04288597,-0.022254877,0.0034377894,-0.005582222,0.0007052669,-0.07412885,0.02503506,-0.039746802,-0.060071487,0.108184755,0.026187781,0.05458426,0.012565739,0.064398736,0.00057017355,0.061282024,0.005702266,-0.009960207,-0.004135059,0.069233805,0.034376945,0.0062601166,0.0051302356,0.036176246,-0.050094284,0.024666036,-0.13785651,0.0049327514,0.06384293,0.03303458,-0.012641483,0.083249636,0.08366485,0.06881673,0.048157513,0.05037528,0.056967277,0.070936166,-0.00461443,0.004095634,-0.012219851,-0.033470087,0.03102077,0.086133204,-0.058318563,0.038653214,0.07589658,0.07448318,0.054995283,0.0046628984,-0.03180005,-0.086142205,-0.06858258,-0.108721785,0.0021229135,-0.037122894,-0.014938929,-0.043932818,-0.004923964,0.031920634,-0.031732712,0.028815314,0.038720794,0.1150825,-0.03830424,-0.053577643,-0.005160597,0.016697366,0.010623603,0.008563941,0.02136398,-0.036126647,-0.028012497,0.054858614,0.010587519,-0.07230176,0.017570116,-0.03401473,0.004498167,0.033154283,0.0012757347,0.0138156805,-0.029458228,-0.06684573,-0.0021175994,0.030392988,0.007644023,-3.067107e-08,0.011630037,-0.014254954,0.04993019,-0.057560615,0.014628091,0.019259365,0.032840196,-0.020087583,0.087342106,0.025400825,-0.05446101,0.029621081,0.057019584,-0.06443071,0.083367854,0.10124269,-0.02199415,0.018576667,-0.035303157,-0.09214879,-0.022452516,-0.020241942,-0.13198635,0.08159965,-0.0017612489,-0.009933937,0.030042235,0.01776161,-0.12183902,-0.0685624,0.024973704,0.017192967,0.019627212,0.018678725,-0.037258007,0.02228725,0.00913005,-0.0043238625,-0.049220063,0.032420687,-0.06110042,-0.07179778,-0.04016281,0.001447738,0.05057185,0.06638289,0.015488577,0.024386724,-0.0102118915,0.023144916,0.04551849,-0.01535709,-0.02114623,-0.11958381,-0.04852498,0.015508193,-0.035322554,-0.049079828,-0.050262265,-0.0073123435,0.09337769,-0.0380991,0.13586427,-0.043050833 +4.1.2.52,"Requires Co2+ or Mn2+ for activity. The enzyme is also able to catalyse the aldol cleavage of 4-hydroxy-2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency. In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate. The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate [4].",384,1.0,0.0020543414,-0.0050164857,-0.07337642,0.029320115,0.046180673,0.037686408,-0.09387745,0.017396329,0.03185348,0.0017425105,-0.011581578,-0.06897085,-0.060548417,0.050313987,-0.026402416,0.11106145,-0.004399357,0.0071447655,0.038499426,-0.03141057,0.055504136,-0.010138119,-0.008650362,-0.030215431,0.048287094,0.033038452,0.034705613,-0.02166184,-8.027784e-05,-0.046151873,0.012370469,-0.09522884,0.041273236,-0.113332406,0.048645496,0.10065234,-0.015981015,-0.04245248,0.06212207,0.027898483,0.007605682,0.004840012,0.03503774,0.03666554,-0.019789483,0.010712366,0.08261045,0.046694823,0.044422463,-0.02750642,-0.04330483,-0.02848229,-0.10547124,0.039612062,-0.0072750803,0.033700548,-0.048460048,-0.012811191,-0.02266182,-0.008914505,0.041029576,0.0023701603,0.0069117863,0.01628798,-0.00479867,-0.07380339,0.03144863,-0.06546038,0.02493109,-0.073379695,-0.034350317,-0.04506642,0.035633273,0.003201152,-0.0054871016,-0.01722279,-0.0058284206,-0.03481186,0.06367079,0.05525806,0.038304877,0.0029146997,0.009430466,0.041885253,0.057753786,0.02691029,0.015682627,-0.03817335,0.024236701,0.046996087,-0.04497912,0.028327964,-0.01682738,-0.04933053,-0.021663232,-0.005043953,0.044098902,0.06663236,0.08443723,-0.010476773,-0.020830316,0.060315404,-0.014998572,-0.10187405,-0.045609087,-0.029455198,0.055361073,0.1337042,0.06292591,0.04470245,0.03547918,0.017590532,0.025038373,-0.00090506533,-0.003406491,0.11536415,0.012970735,-0.08816262,-0.1169552,0.023789117,0.014961972,-0.03277974,0.058002397,0.029935138,-0.058042973,0.010922825,-0.05722215,2.7581212e-33,0.0839766,0.018510003,-0.007463293,-0.0016873333,0.022110164,-0.0007709753,-0.103472985,-0.017368702,-0.04986672,-0.0035315591,-0.07479795,-0.08532065,0.06991881,0.102168374,0.004758411,-0.068572305,-0.043780193,-0.013064309,0.08578382,0.0012567331,0.008778628,0.021426646,0.002472424,0.095981166,0.013247725,0.036850017,0.07418726,0.02605228,0.0020756205,-0.026642127,-0.006218612,-0.051835597,-0.122884676,-0.06262921,0.030310191,-0.049128465,-0.07103503,-0.032669507,0.0008317063,0.045697868,-0.03885255,0.054787382,-0.027114047,-0.053580817,0.08883708,-0.090159364,-0.03166536,0.1076321,0.015761148,0.09216488,0.026927713,-0.01156951,0.042008486,0.013694564,-0.10657868,0.00038898204,0.023025181,0.0003692921,0.047683377,-0.0063189096,0.015856257,0.09658694,0.009241671,-0.021042721,-0.037220407,-0.01672255,0.035788815,-0.029605184,-0.02285464,0.040547933,-0.04268179,-0.0600934,0.0035805136,-0.010003427,-0.0017428765,-0.06519307,-0.060368408,0.038540468,0.11863987,-0.0668728,0.033053063,-0.008874913,0.07248304,-0.006183812,-0.038999118,-0.007154306,-0.039502002,-0.014413915,0.031869806,0.084927015,-0.010398646,-0.032761425,-0.033782102,-0.006984655,0.030120596,-3.565574e-33,0.12534355,-0.09965136,0.030469673,-0.08102352,-0.074076235,0.024899999,-0.024492543,-0.081568085,0.004249075,0.007923384,0.0696243,7.4515214e-05,0.0941439,-0.011217773,0.056368176,-0.052494615,-0.06273522,0.05170314,-0.011119192,-0.010696748,0.09069031,0.05552407,-0.013340392,-0.06464587,0.09714277,0.01202814,-0.0144676985,0.014212567,0.09548544,0.05172861,-0.04038749,-0.06553538,-0.02655196,-0.069007084,-0.022758825,0.094305515,-0.06765825,0.025166845,0.015819386,0.04709189,0.03559446,0.00018719994,0.0010796959,0.05698096,-0.024974136,-0.0036156217,-0.08745674,-0.008164652,0.029045228,-0.058684763,0.037500076,0.025224078,-0.110615544,-0.03813121,0.008540827,0.030590387,0.01182832,-0.03257136,0.001922795,-0.07208152,-0.09195392,-0.10236176,0.086194456,-0.036806617,0.028983835,0.037065048,0.018860705,0.025911735,-0.019234058,0.013305766,0.08648563,0.0047770995,-0.00043133364,0.028505635,0.0035181236,-0.043114834,-0.028297583,-0.0156061025,-0.011178962,-0.007734577,-0.01620152,-0.013751206,0.078515366,-0.0991673,0.010126171,-0.084481485,0.034114942,0.08351395,-0.027313862,0.07007172,0.034013253,-0.0365127,0.0045541045,0.010092605,0.028803406,-4.701564e-08,-0.07721876,-0.025921397,0.092194594,0.011146133,-0.07154477,0.029628273,0.04187422,-0.015525474,0.058904346,-0.04949847,0.048168883,0.085882865,-0.0023772246,-0.004601983,0.06113882,-0.024353517,-0.087344095,0.019965416,-0.026594352,-0.028692387,-0.08775153,-0.06427342,-0.08513072,0.008356712,0.029018076,-0.051837537,-0.004277315,0.03481303,-0.025047226,-0.032321986,-0.00868718,0.06474501,-0.008275289,-0.07594583,-0.070225,0.0011868416,-0.051440403,0.0076140957,-0.0461659,-0.027107798,-0.018845642,-0.059286747,-0.08368879,0.057068676,0.015284394,0.0053908867,-0.017949747,0.0019387052,-0.059345383,0.04732019,0.10487216,-0.072770536,0.017922875,-0.022124738,-0.08060547,0.08221228,-0.013841317,-0.052143794,-0.024739081,-0.06064964,0.046376646,-0.0056104935,0.17266889,-0.07421678 +4.1.2.53,"Requires Mg2+ for activity. The enzyme can also use 2-oxo-3-deoxy-L-mannonate, 2-oxo-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) as substrates [2].",384,0.99999994,-0.017014334,-0.07857231,0.022088341,0.0023050914,0.037081547,-0.06762455,-0.02132757,-0.021498427,-0.05002731,0.031301968,0.005446608,-0.057221964,-0.0009915038,0.03765048,0.022558773,0.05949689,0.047850862,0.056270074,0.023031168,0.009618475,0.13908468,-0.022444392,0.0054594735,0.032126363,0.034161925,0.05599821,0.07494763,-0.013880669,-0.009970187,-0.07773791,-0.02236203,-0.042733032,0.029804038,-0.054991215,0.0020185383,0.09917686,-0.10908012,-0.00880858,0.0017996067,-0.05125346,0.03736592,-0.03381287,0.0745572,-0.062890686,-0.026570728,-0.13944381,-0.0031468573,-0.01711258,0.039854415,0.09025539,-0.009874025,-0.03500964,-0.0303885,0.031743754,0.0032796552,-0.011661318,-0.10071554,0.066632725,-0.034444552,0.031588145,0.020633627,0.037131984,-0.039759297,-0.037666094,0.012584202,-0.037991717,-0.0029556833,-0.035736512,-0.004801006,0.014366177,0.00443991,-0.09849378,0.022783186,-0.014591887,-0.01448192,0.029936872,0.056575194,-0.057403307,0.0723262,-0.00048661174,0.026683658,0.013188803,0.09147799,0.1316922,0.047813717,0.045457218,-0.0078935735,0.013658357,0.032254964,0.015267602,0.08327069,0.05147909,-0.07976813,-0.008331309,0.022137836,0.0004036865,-0.07088568,0.08826772,-0.01392274,0.00815016,0.009367198,0.04426545,-0.024839314,-0.047533937,-0.07363478,0.012880552,0.013416679,-0.051952835,0.03287276,-0.02246433,0.028951121,-0.017403072,0.03164155,0.038117807,-0.03576972,0.09256332,-0.022337902,-0.10629179,0.011992866,-0.03126967,0.02001548,-0.0073839184,0.053426944,0.022650652,-0.0784113,0.025447868,-0.061993882,-8.869487e-34,-0.009381793,0.009274394,0.06895133,-0.0137097575,-0.019073615,0.014159003,-0.04840734,-0.022977438,-0.03901014,-0.052383363,-0.109399125,-0.009697857,0.020101959,0.044997334,-0.0060587293,-0.026451023,0.041495115,0.010647289,0.061132275,0.021735422,0.009534239,0.00616322,-0.05291698,0.03321464,-0.01913342,0.11513598,0.05124246,-0.021161122,0.052331302,0.037868276,0.005336206,-0.09981097,-0.014623027,0.01525809,0.0068825274,0.014591813,-0.07628151,-0.009002795,-0.023474222,0.041698534,-0.06419881,-0.0005384363,-0.04300034,-0.011797642,0.019044632,-0.054287314,0.017786203,0.08732101,0.029600065,0.08934884,0.14651658,-0.03857691,-0.029989667,-0.019075617,-0.107208565,0.07368721,-0.044165354,0.04111483,0.15014122,-0.009771921,-0.0406544,0.0042052567,0.0040095407,0.013405051,0.071060434,0.047389384,-0.06311462,-0.030769015,-0.092785776,0.015963547,-0.027005801,-0.026934821,0.0538353,0.03747183,0.014498835,-0.012815339,-0.0012855066,-0.00078728684,0.06996398,0.033635765,0.032149855,-0.057133578,-0.025968509,-0.022722585,-0.042232763,-0.020831438,-0.027720803,-0.033279758,0.026401931,0.058342062,-0.02097753,-0.046936497,-0.06259128,0.034068417,0.0012300502,-1.0484334e-33,0.04011517,-0.03213035,0.046741992,-0.03209607,-0.06771087,0.06670368,0.08662891,-0.13661125,0.107485764,-0.01847105,0.053682677,-0.018000951,-0.011544473,-0.058903925,0.03248839,0.0033045057,-0.08075114,0.066040784,-0.007851253,-0.0150953345,0.072492264,0.08603262,-0.027628332,0.05688304,0.07008686,-0.008575857,0.018591827,0.045037605,0.12226474,0.066733986,-0.040786404,0.023155587,0.039966706,-0.028472528,-0.034021556,0.10679621,-0.05034156,-0.0073588192,-0.044036187,0.06382008,-0.115216516,0.027397607,0.047738664,0.07167731,0.015413986,0.06290456,-0.03424121,-0.01644192,0.048136804,-0.08638811,0.04382721,-0.03154325,-0.08185919,-0.03345669,0.011964746,0.05573953,-0.0525698,0.013665172,0.030456487,-0.035210628,-0.042273633,-0.06406858,0.06329598,-0.029877936,-0.050415333,0.097702496,0.0013624658,0.009299423,-0.054148186,0.035085082,0.033311024,-0.0009945333,0.070665486,0.03761073,9.3260576e-05,0.039225962,-0.08043178,0.010564692,0.008406228,-0.062442593,0.045533102,0.020644251,-0.029131977,-0.05733487,0.025172248,-0.09440758,0.02316877,0.078992896,-0.017314121,0.016369404,-0.05323783,-0.020321488,-0.06482805,0.06724902,0.037076134,-4.6204388e-08,-0.002599822,-0.10135544,0.08916987,-0.074515566,0.010813894,0.06911969,0.033585694,-0.027347794,0.04849702,-0.05414162,0.0063570184,0.015682103,-0.059054393,0.0017308589,0.01581522,-0.015530438,0.016409198,0.05866084,-0.040924825,-0.033548098,-0.065608226,-0.055402312,-0.06592182,-0.02227595,0.02224644,-0.06365753,0.008727884,0.046111617,-0.01244816,-0.023949405,0.0020977552,0.04722503,-0.02295276,-0.05190097,-0.12150507,0.04445906,-0.09784861,0.007100845,-0.048373267,-0.015982948,-0.056757916,-0.040059935,0.07444218,-0.007953149,-0.034997664,-0.011088873,-0.011590973,0.02233953,-0.038192824,0.024742361,0.016073357,-0.07355741,-0.05703771,-0.03817281,-0.04235907,0.029322477,0.040490262,-0.0663695,-0.05090216,-0.14224066,0.0017527741,0.042852104,0.14221533,-0.023371253 +4.1.3.43,"Requires Mn2+ for maximal activity [1,2]. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase [1,2,6]. The enzyme forms a bifunctional complex with EC 1.2.1.87, propanal dehydrogenase (CoA-propanoylating), with a tight channel connecting the two subunits [3,4,6].",384,0.99999994,-0.041499645,-0.035124358,-0.071382776,-0.011820742,0.019040963,-0.008513318,-0.102935515,-0.00097371166,-0.012460643,-0.0036051655,0.023699986,-0.12689401,0.021351017,0.03436118,-0.019254833,0.09708361,-0.045145903,-0.021621697,0.039360546,0.012627814,0.0796348,0.037533596,-0.023785194,0.029103633,0.06272161,0.08352764,0.074501455,0.000114311515,-0.040117007,-0.024142455,-0.033826087,-0.074093744,0.1292485,-0.053858973,0.044952758,0.12851207,-0.05210634,-0.07733182,0.03141735,0.050221343,0.051936198,-0.027639423,0.0550436,-0.053511325,-0.020080118,-0.010337942,0.10454026,-0.017908586,0.05466827,0.019047858,-0.04859876,-0.05845512,-0.01017439,0.034709062,0.013059803,-0.0060863127,-0.057643443,0.004158568,-0.060651835,-0.019858789,0.09585427,-0.020244904,-0.013167728,0.04236262,-0.034182858,-0.053529106,0.016356135,-0.070246525,0.020200454,-0.064046174,0.009226025,-0.053837758,-0.013509617,-0.012963387,0.009621266,-0.0046033375,0.05407026,-0.08541305,0.07111691,-0.042247403,0.009936749,-0.060487013,0.04848334,0.031027041,-0.015887469,0.0265925,0.059780445,-0.0051208497,0.029958226,0.016533578,0.010053752,-0.004823289,-0.019734068,0.0027545376,-0.013259983,0.0027506466,0.017980618,0.08004977,0.059640083,-0.047788884,-0.040051114,0.07490674,-0.04790529,-0.06716243,0.02896804,-0.0249108,0.04015428,0.13749468,0.009443032,0.030840278,0.035509985,-0.02108641,0.06332212,0.05710719,0.04855497,0.08793218,0.03744378,-0.071254365,-0.057397265,-0.014520606,0.05004199,-0.027831702,-0.02082597,0.04336807,-0.032830004,0.06229048,-0.10120759,1.3943932e-33,0.083591275,0.02277556,-0.043273505,-0.032736238,0.011508647,-0.0020633286,-0.06833926,-0.0028665783,-0.004754731,-0.061289623,-0.05135944,0.002727505,0.03726226,0.08839663,-0.024045968,-0.075057186,-0.0009869904,0.004666449,0.09158024,0.048843585,0.009253784,0.047945697,-0.025689587,0.027417982,0.014083564,0.04074627,0.120822,-0.0119118495,0.012757691,-0.009577326,-0.0039440645,-0.16656369,-0.16105212,-0.019741692,0.053698212,-0.036602065,-0.06187505,-0.009116956,-0.054283585,0.02084437,-0.04153043,0.07974194,-0.05474875,-0.021635346,0.05970625,-0.06969534,-0.03143365,0.13905184,0.03426827,0.06759644,-0.008537967,-0.014856738,0.10191304,-0.017805668,-0.07042428,0.0019676094,0.011874733,0.05730485,0.015575292,0.018778602,-0.016251093,0.1093689,0.02554859,0.08658811,0.027476475,-0.012857151,-0.04007845,-0.057569634,0.02333773,0.022867925,-0.057360657,-0.023367364,0.03548912,-0.067127354,-0.0004735487,-0.06965988,-0.058769356,-0.03372022,-0.018046744,0.01493192,0.018362354,0.00063689443,0.10021621,0.022754684,-0.03617884,0.024704607,-0.031791817,-0.009923758,-0.007506081,0.079379156,0.021245163,-0.03141881,-0.026607439,0.02246747,0.004286216,-2.0087689e-33,0.07555407,-0.11335004,0.06741421,-0.053332124,-0.14462677,0.07998721,-0.024496494,-0.045039788,0.0016695582,-0.022692777,0.13501543,0.043735117,0.051988583,-0.06638034,0.038264036,-0.0145223485,-0.027682813,0.09256938,-0.0015671493,-0.027914053,0.027425928,0.093486756,-0.0007933594,-0.022769993,0.00782917,-0.0059928107,0.019811837,0.024418049,0.011132556,-0.0047800126,-0.047335334,-0.023313496,-0.052435897,-0.03279138,0.011478971,0.07067094,-0.076601,0.016089542,0.08900782,0.027230062,0.018170323,-0.025475534,-0.021238089,0.06646931,-0.0008512138,-0.031251367,-0.03952202,-0.015422088,-0.0034394357,0.017959394,-0.011440975,-0.041324567,-0.086429976,-0.042855587,0.012538163,-0.011309169,0.007975674,0.010723139,0.020669488,-0.06765477,-0.037651684,-0.07224781,0.0815397,0.022495277,-0.014293077,0.08531253,-0.04790764,0.011625499,0.050218444,0.031889934,0.08978342,-0.030627267,0.016527103,0.01749386,0.007744544,-0.023681048,-0.060078096,-0.008129926,0.0006173014,0.0097425375,0.0342364,0.017254911,0.063344635,-0.04994404,0.051063523,-0.057139523,0.06404674,0.09431519,-0.08315677,0.014422651,0.039642587,-0.07505855,-0.008855192,0.035992406,0.029780945,-4.5363432e-08,-0.010675319,-0.05977978,0.0763025,-0.028666612,-0.018948147,0.0055427067,-0.04709295,-0.062413987,0.05245399,0.004523514,0.037547108,0.05088316,0.016983343,0.020527355,0.036354166,-0.0337097,0.020490589,0.025278224,-0.051220506,-0.0404584,-0.04888174,-0.112703115,-0.12651277,0.031856384,0.036087297,-0.02722257,-0.029439982,-0.013447494,0.060668197,-0.024423055,-0.014490905,0.029546555,-0.016210357,-0.0571086,-0.044452883,-0.015188463,-0.04526735,0.040399037,-0.060702443,0.023828212,-0.0032230741,-0.113368995,-0.012714522,0.04086991,-0.00122466,-0.004502477,-0.014654781,0.012821989,-0.032413892,-0.01585266,0.07963851,-0.05801474,0.0322959,-0.044960976,-0.09329393,0.053606275,0.0028096552,-0.07456843,-0.024006357,-0.0029649949,0.023655448,0.04424669,0.087542266,-0.093268074 +4.1.99.20,"Requires Mn2+ for maximum activity. The reaction is suggested to take place in several steps. Schiff base formation, double bond migration and dephosphorylation followed by ring opening and closing to form a pyrrolidine ring, and finally dehydration to form the product 3-amino-4-hydroxybenzoate. In the bacterium Streptomyces griseus the enzyme is involved in biosynthesis of grixazone, a yellow pigment that contains a phenoxazinone chromophore.",384,1.0,-0.0035406747,-0.015504169,-0.13705327,-0.057581313,0.045144174,0.041137826,0.08728179,0.04284127,0.027434217,-0.016309913,-0.006371849,-0.013857175,0.021487083,0.029155271,-0.05484156,0.052314837,-0.0742261,-0.010682003,0.035895094,0.0045993244,0.11139359,-0.013659894,0.029822834,-0.08098103,0.052141994,0.062488597,0.07401443,-0.023725618,-0.0346443,-0.07441165,0.038872577,0.073400036,0.034966826,-0.08325265,0.07938916,0.08163467,-0.004208524,-0.007823178,0.030717565,0.04733395,0.010226685,0.034900088,0.027705235,-0.00849894,-0.026304081,0.012652199,0.1098448,0.084852405,-0.0050668893,-0.009594135,-0.05714202,-0.10280785,-0.017358603,0.018883644,0.011881406,0.057766583,-0.035433978,0.0001625052,-0.041934464,-0.08496495,0.044278283,-0.07860205,0.010807504,-0.015194017,-0.023977345,-0.028030867,0.008819911,-0.124416396,0.06256017,-0.023131821,-0.026013022,-0.016185438,-0.009266416,0.0012609869,-0.053952284,0.059831973,0.040185194,-0.0025951033,-0.029194323,-0.034250583,0.013469762,0.00020305955,0.054987997,0.093372345,0.116382845,0.063017994,0.026014127,0.0115977945,0.034239065,0.02184115,0.016922392,0.05870348,-0.023072287,-0.0108701,-0.110969655,0.10019438,-0.044712298,-0.0025770376,0.021328826,0.0109907305,0.024113655,-0.007937055,0.00059654133,-0.045424066,0.04492804,-0.013604024,0.030624345,0.1453601,-0.049251106,-0.03367901,-0.019312436,0.033127178,0.02765096,0.024574714,0.0068441494,0.07767966,0.12980291,-0.025935374,-0.07003307,0.0021550884,0.049247257,0.05265689,-0.02277983,-0.040272396,-0.034169555,0.055550896,-0.081965946,4.8820268e-33,0.038982604,0.0670986,0.00068734755,-0.046442684,0.019340018,0.013740341,-0.09689689,-0.016803563,-0.013516633,-0.060349703,-0.08015966,-0.088230886,0.0103472965,0.021425199,-0.029522333,-0.037683297,-0.012860504,0.036030423,0.10544714,-0.021976793,-0.008032292,0.025506647,-0.052601475,-0.016380297,-0.035514362,0.06661076,0.07147509,0.02670332,0.059373252,-0.045027133,0.030393047,-0.05731608,-0.06483021,0.01144503,0.015744723,-0.0050289566,-0.057448838,-0.035175454,0.01729998,0.044633888,-0.07079717,0.01766548,-0.03580342,0.021121953,0.056723174,-0.04600515,-0.052322045,0.083379045,0.061542794,0.019864442,0.03784182,-0.0025076666,0.093204804,0.06656593,-0.1229217,0.057654515,0.031267647,-0.0063943355,0.060700808,-0.0041643837,-0.036188576,0.042976283,0.012135529,0.04608378,0.032393567,-0.05443074,-0.01932703,-0.058031693,-0.017738186,0.015917698,-0.041115407,-0.06698891,0.06265034,0.017946381,-0.020920629,-0.03607441,-0.0660022,-0.13328882,0.06057206,0.04010701,-0.015192522,-0.009878804,-0.04707262,-0.03867906,-0.091886915,0.009952449,-0.04756177,-0.044376645,-0.0033068098,0.014711772,-0.0067105237,-0.04931815,-0.08069168,-0.026681073,0.019388823,-4.49734e-33,0.075675346,-0.026760317,0.0441611,-0.027805068,-0.05619098,0.004337984,-0.039701752,-0.07147292,-0.029044736,0.012383311,0.075168885,-0.04725681,-0.019711405,-0.024337512,-0.03805852,-0.04702344,0.058787156,0.07437137,0.027598226,-0.032515742,0.017866665,0.08386966,-0.00054506084,-0.00042990467,-0.029849015,0.028448699,0.08631156,0.0062420648,-0.005629788,0.052000254,-0.0146680605,-0.063886836,-0.05305571,-0.039264295,0.036600113,0.039000053,-0.06721889,0.010432529,0.07309544,-0.025095867,0.05692525,-0.057865087,0.06773543,0.11276918,0.083233915,0.004775359,-0.08299306,0.07469922,-0.03948547,-0.018557133,-0.03217883,0.02251608,-0.058387853,-0.049048863,0.07233709,-0.030065794,0.018929716,-0.079707935,0.0115286745,0.021359509,-0.02242086,-0.02212859,-0.022698376,0.013781162,0.05457569,0.075598784,-0.015709559,0.108593285,0.06495851,0.01625895,0.03069957,0.009402955,-0.010730328,0.094329394,-0.04490732,-0.02788865,-0.05454834,-0.0029829058,0.01654349,-0.049151808,0.028067578,-0.0405809,0.053829517,-0.051287834,-0.011423433,-0.14244927,-0.001131614,0.077420674,0.016746232,0.0042401706,-0.015006569,-0.010055133,0.017827772,0.024963744,0.003461133,-4.2391097e-08,-0.02131403,-0.054031152,0.10113398,-0.04654214,0.009119993,-0.039934874,-0.015265408,-0.020667858,0.13037333,-0.07170865,-0.052035183,0.010312817,0.020896215,0.014529733,0.048732266,0.0935338,-0.025708385,-0.031831454,-0.05098142,-0.07197949,-0.0933866,0.0017698652,-0.14116527,0.07626983,0.029154127,-0.008944637,-0.013064528,0.0807388,0.025873601,0.019738136,0.037474416,0.026875537,0.018531337,0.02122724,-0.02106253,0.00506796,-0.071795575,-0.020129772,0.03532507,-0.05619018,-0.0728835,-0.002852722,-0.0430737,0.004167829,-0.07150978,-0.023029635,-0.03089201,0.0035674493,-0.05889142,0.015246806,0.03899126,-0.0267339,0.024588456,-0.013463369,-0.15263844,0.05415416,0.008516696,-0.031929743,-0.022113176,-0.038611878,-0.040002447,-0.021760626,0.08229305,-0.024837963 +5.1.1.19,"The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.",384,1.0,-0.009895993,0.0010167692,-0.091132894,-0.036560584,-0.029522114,0.012804824,-0.029772088,0.074017346,0.06349573,0.005704981,-0.06622575,-0.020249596,0.0069605745,0.051414073,-0.0054067355,0.016308568,-0.105058216,0.036719866,0.08833082,-0.034443386,0.11621741,0.072770976,0.044196725,0.0016537951,0.020980855,0.013246829,-0.00023601616,0.043766562,-0.02446843,-0.027582264,0.036995735,-0.03354701,0.06695722,-0.0036562518,0.04801016,0.06659334,-0.052810095,0.02645476,0.068913706,0.028637806,-0.0058023427,-0.023454998,-0.03158394,0.08063266,-0.052190844,0.03194875,-0.012591561,0.08205877,-0.011861934,-0.03577294,0.031099005,-0.06628813,-0.02851985,0.10615444,0.015240267,0.121850505,-0.038625482,0.052764427,-0.04065287,-0.07236263,0.091060676,0.045635317,-0.01596037,0.028301297,-0.0049462635,-0.059680566,0.0034664168,-0.040053282,0.019533308,-0.0770369,-0.035716224,-0.075168654,-0.011718983,0.007706304,0.036808055,-0.050792743,-0.015570585,-0.037912156,-0.026581649,-0.05026132,0.12010665,-0.008926221,0.03211897,0.13624243,0.051024914,-0.01719883,0.036003705,0.00017681875,0.0028481958,0.016756805,0.07093872,-0.020680215,-0.045733605,-0.0660781,-0.05907447,-0.03026956,-0.041680064,0.070465215,0.048012793,-0.0074902414,0.014239711,0.060875166,-0.028068017,-0.037737653,-0.0047865757,-0.0074721198,-0.038018342,0.047629103,0.023047237,-0.06570903,-0.0030872272,0.015424635,-0.010764918,0.054271102,-0.01163081,0.07935374,0.0539129,-0.020322498,-0.038404323,-0.07458703,0.007168987,-0.058827545,0.009967507,0.051060192,-0.039789636,0.042426858,-0.10391388,-4.3533786e-34,0.023142744,0.037055198,0.031186698,-0.06759627,0.020912554,-0.009032359,-0.06258537,-0.00039502705,-0.035004202,0.040114857,-0.079349674,-0.095566176,0.03997317,0.08229455,0.034386694,-0.06739141,-0.026195195,0.059272293,0.077766344,-0.0020948017,0.021360297,0.06346362,-0.06178833,0.007309361,0.01803006,0.08350682,-0.030181725,0.11598743,0.05072767,-0.021963418,-0.036189914,-0.07637791,-0.058064274,0.008605612,0.058639076,-0.048692085,-0.05503537,-0.03393383,0.013049667,0.015553441,-0.040059924,-0.028877558,0.05084529,-0.037014574,0.028999818,-0.042018585,-0.117616355,0.041649647,0.075994655,0.0642139,0.092272565,-0.07444255,0.104053244,-0.024017692,-0.048424836,0.053689376,-0.027549587,0.008181533,0.025785964,0.032553896,-0.02341067,0.023509923,-0.053629346,0.025572488,0.036771808,0.03850151,-0.04690708,-0.07115442,-0.03493884,0.09770672,-0.1186938,-0.00262013,0.035431698,-0.057508104,0.008481246,0.028006317,-0.076999485,0.025941884,0.054848284,0.0046207486,-0.0036892206,-0.05660208,-0.036290802,-0.01878207,-0.0034724171,-0.000808891,-0.026791522,-0.10011276,-0.02538477,0.073492326,-0.012385876,-0.08456683,-0.0813507,0.052471988,0.08278335,-2.3164564e-33,0.08829661,-0.04322483,0.040687118,-0.08147469,-0.05851264,0.07829705,-0.027599514,-0.069881976,0.0129446555,-0.017133621,0.041608542,-0.008466651,-0.05001429,0.01663113,-0.014327117,-0.0037862165,-0.002117738,0.040591855,-0.067959085,0.030863052,0.02670274,0.031255808,-0.019530592,0.022546664,0.05541476,-0.025257,0.012955019,0.07809666,0.057115994,0.029464658,-0.00091292267,-0.05369719,0.027681848,-0.04974243,-0.040520646,0.101747714,-0.102714665,-0.0038286843,0.03217607,0.008022575,0.03390053,0.007529497,0.017098857,0.09179517,0.046763442,0.07933356,-0.06485368,0.05432792,0.006554467,-0.08701907,0.005055618,0.024773689,0.01274044,0.011522892,0.015633825,0.03783955,-0.012637154,-0.014977014,-0.016628217,-0.054393623,-0.0037053442,-0.06265603,0.008495197,-0.005192995,0.030666713,-0.04715871,-0.06368679,0.04180419,0.025882563,-0.0007424888,0.03538073,0.0089399675,-0.024920516,0.02020206,-0.09169831,-0.053136766,-0.09588979,-0.050822966,0.03374948,0.035678927,-0.0066826562,-0.013967356,0.008237067,-0.030221865,-0.056028653,-0.07787089,0.026581023,0.09265437,0.008289795,0.023316493,-0.020115942,0.062387493,-0.009726177,0.02592017,0.02513308,-3.3173194e-08,0.030887224,-0.0810269,0.06352844,-0.07883927,0.007449599,-0.04547324,0.02864461,0.007717965,-0.0044047083,-0.055968318,-0.08701573,0.07521235,0.0086105,-0.030460833,0.05763211,0.0545155,-0.05537718,-0.018541679,-0.042539567,-0.022321925,-0.07013514,-0.051259078,-0.113645576,0.028414143,0.03421271,-0.054732695,0.062377892,0.045828614,-0.027148893,0.067287326,0.077122,0.0203505,-0.04833566,0.0062956717,-0.036880888,0.011537177,-0.09403704,-0.053385925,0.032394398,-0.062748894,0.01769343,-0.019259987,-0.08052385,0.0564569,-0.030949645,0.037166767,-0.011280397,0.026596393,-0.05477965,-0.006921281,0.011591434,-0.022264564,-0.03765859,-0.02120355,-0.0656991,0.047416054,-0.0068152645,-0.05309701,-0.04597296,-0.05647333,-0.0046636057,0.028193198,0.22935326,-0.06400204 +5.4.2.12,"The enzymes from higher plants, algae, some fungi, nematodes, sponges, coelenterates, myriapods, arachnids, echinoderms, archaea and some bacteria (particularly Gram-positive) have maximum activity in the absence of 2,3-bisphospho-D-glycerate. cf. EC 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent). The enzyme contains two Mn2+ (or in some species two Co2+ ions). The reaction involves a phosphotransferase reaction to serine followed by transfer back to the glycerate at the other position. Both metal ions are involved in the reaction.",384,0.99999994,0.05094894,-0.066960044,-0.03092642,-0.026408268,0.07019817,-0.007946871,-0.010266014,0.021117363,0.037216716,0.05643779,0.039375186,-0.03256094,-0.0152550815,0.03970822,-0.047225054,0.0061364174,-0.03391257,-0.0016654327,-0.056968737,0.0523222,0.19295157,0.00031687293,-0.025602292,-0.016114054,0.023478897,-0.0004221761,-0.024069255,-0.09687627,-0.0350507,-0.034761824,-0.074158594,-0.005599245,0.09895171,-0.03270699,0.07339214,0.067388825,-0.023243368,-0.016526548,-0.028261647,0.007953168,-0.0028545456,0.00099249,0.037850395,-0.07340529,-0.061009463,-0.021392157,0.036706794,-0.076030076,0.016348481,0.0050516617,-0.084058724,-0.077140845,-0.05932475,0.04855294,0.026930494,0.0033008133,-0.085663676,0.064562395,-0.018784551,-0.06498749,0.011802119,-0.02634732,0.09403051,0.004330433,0.09292265,-0.033603206,-0.031303544,-0.06675358,-0.02732968,-0.009951857,-0.040693402,-0.03282419,-0.001134224,-0.045266323,0.011134221,0.05331469,0.024890492,0.009907838,0.04548978,-0.069385424,-0.003012497,-0.004089214,0.05352581,-0.0040966794,-0.0053577847,0.056047056,0.0024178238,0.044266853,0.019389816,0.0103334645,0.023374729,0.0057438477,0.038470462,-0.0196938,-0.026952922,0.04358351,0.015243564,0.03771016,0.0073854364,-0.018252214,0.0049644583,0.11466867,-0.0009446147,-0.07319147,0.00064191007,0.016882706,-0.018190013,0.025795681,-0.010187858,-0.0068517462,0.044624206,0.030319411,0.037349433,0.0698181,0.001942471,0.08285184,0.06631241,-0.07468427,-0.033092596,0.0005327371,0.021367814,-0.069677055,0.024297504,0.046136156,-0.04752655,0.14560951,-0.09222602,2.1986154e-33,0.086190164,0.0021758596,0.015471786,-0.02402635,0.00694895,-0.04905079,-0.047213264,-0.029842174,0.0030183662,-0.034051344,-0.08600154,-0.02684544,0.07750967,0.05866075,0.0058440147,0.0075648236,-0.002619085,-0.027057447,0.119703196,0.0021101045,0.030508121,0.02007111,-0.043057907,-0.0037381847,0.07214593,0.057796706,-0.008126928,-0.022109337,-0.012566971,-0.029141532,0.0793539,-0.114808224,-0.08195275,0.043669198,0.07035127,-0.0086684795,-0.058388896,-0.024246866,-0.04976635,0.0028916576,-0.04701374,-0.002216365,-0.01100321,0.003728123,0.09445035,-0.06726922,-0.0869837,0.071631566,0.05051585,0.09344844,0.024289016,0.012706902,0.05917919,0.00018562956,-0.08207536,0.0038383957,-0.005230892,-0.026254669,0.013273103,0.08277416,-0.055011127,0.034662053,0.0016644802,0.048819546,0.011891564,0.06527021,-0.13970177,-0.026366057,0.026767021,0.09267661,-0.043391846,-0.09614341,0.04340391,0.02513462,-0.029209713,-0.067205,0.005298317,-0.06980388,-0.030404516,0.01850774,0.01694796,-0.01729233,0.010370748,-0.022193765,-0.13483295,0.026357817,-0.03309085,-0.11862195,-0.009525893,0.04449686,0.022632618,0.017971179,-0.06941551,0.014970513,-0.027737074,-3.685129e-33,0.11299872,-0.052978568,0.042960495,-0.078520305,-0.09825208,0.08518964,-0.0042901756,-0.020104034,0.023388052,-0.050577573,0.033471387,0.02793777,0.069451004,-0.044683326,-0.010644066,-0.004297378,0.0633436,0.06164822,0.080005266,-0.011570444,0.03894722,0.10935908,0.023670675,0.042001452,0.079688996,0.014510961,-0.012382515,0.04912699,-0.047671605,-0.0047437353,0.021725433,0.023744754,-0.007181611,-0.07684007,-0.06159588,-0.023042243,-0.10465775,-0.019424604,0.021559218,0.04837197,-0.015853697,-0.022582753,0.10901619,0.1000465,0.027311591,0.03032117,-0.08461144,0.03757238,-0.0057397187,0.003993136,-0.011259099,-0.034001168,-0.01210026,0.012253655,0.11510661,0.032575656,-0.0011829638,0.032072622,-0.057898425,-0.013572917,-0.005272993,-0.057055056,-0.015053516,0.011033371,0.057444554,0.075306736,-0.045723148,-0.016135687,-0.02235013,0.036016,0.030424118,0.018240964,0.022638934,-0.011164816,-0.053287018,-0.04429201,-0.08972943,-0.0066979574,0.020998808,-0.07763955,-0.04529049,0.09823555,0.07193666,-0.0784866,0.004018854,-0.095033176,-0.015281198,0.11397735,0.018148385,0.0061675315,-0.050920244,-0.07484158,-0.040720176,-0.03541995,0.055573236,-4.5726075e-08,0.04333035,-0.01570619,0.021053098,-0.070843965,-0.012384894,0.0059212833,0.026010798,0.020685386,0.024557063,-0.012302044,-0.033787582,0.033642657,0.030490853,-0.050226726,0.09152216,0.059255164,-0.005629466,-0.013149738,-0.06540787,-0.03805124,-0.078534976,-0.0673717,-0.12807067,0.12051491,0.022751879,0.0057848166,0.043491513,0.04838809,-0.053098656,0.0074900766,0.009385183,-0.018140532,0.044842593,-0.037260696,-0.037841376,0.025921602,-0.0627751,-0.034356568,-0.04448051,-0.011290275,-0.07436531,-0.030121945,0.015541234,0.014829533,-0.015698355,-0.0024491542,-0.0311572,0.010733872,0.0046852375,-0.013647526,0.048234757,-0.053627472,0.009908319,-0.052817214,-0.11878018,-0.010195986,0.031339765,-0.018335097,-0.017539445,0.021740688,0.08312098,0.014456972,0.109551154,-0.051910117 +6.3.1.15,The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. 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+6.3.3.5,"The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.",384,1.0,-0.01909654,0.0056167715,-0.09209462,-0.021635415,-0.05419295,0.028553633,-0.050653957,0.033844553,0.059977405,0.0020175974,-0.10054462,-0.009357452,0.018783934,0.046078227,-0.035994187,-0.008063212,-0.04394564,0.015506832,0.07044846,-0.02018929,0.1054793,0.068102315,0.06639082,0.0030770137,0.05712156,0.0036882737,0.028573398,0.028646456,-0.04210744,0.027913844,0.023656992,-0.041305527,0.077288575,-0.041332383,0.1270948,0.06692976,-0.028000198,0.02950759,0.099676006,0.043119736,-0.038508564,-0.0062153544,-0.029805027,0.11304604,-0.065223366,0.03431293,-0.019258974,0.055104617,-0.009860659,-0.06315269,-0.011246725,-0.05947824,-0.0668333,0.07057222,0.07002547,0.0831387,-0.027745305,0.023265962,-0.032464676,-0.07277686,0.06011554,0.021396728,0.02306504,0.038598776,-0.05724025,-0.020297334,-0.013398581,-0.036730196,0.039855685,-0.08795777,-0.05330283,-0.07702488,0.002629019,0.0068268212,-0.011215799,-0.0476141,0.013503927,-0.04618876,-0.07192536,-0.037578825,0.14322858,0.0015781685,0.0041234354,0.10088674,0.048218116,-0.002255893,0.040578872,-0.025722114,0.015226975,0.042685874,0.040618606,-0.03287351,-0.03494388,-0.06355132,-0.057525326,-0.050457925,-0.054529216,0.047845867,0.032679357,-0.028642362,0.00729546,0.07369743,-0.029094595,-0.012492086,-0.005931648,0.0056893877,0.0005480165,0.060685113,-0.018161777,-0.03717721,-0.0016327635,0.009650097,-0.017615143,0.061812963,-0.023340778,0.07260583,0.078838065,-0.026619747,-0.034891967,-0.033710055,0.01112839,-0.045123037,0.018005563,0.053745285,-0.011154641,0.07219794,-0.07956477,-8.852621e-34,0.011969762,0.044853583,0.016083457,-0.07372052,0.014171026,-0.018218221,-0.0455446,-0.03699185,-0.0028032502,0.017159132,-0.113555945,-0.122619584,0.026337462,0.08935812,0.026028523,0.010361606,-0.030038638,0.055454645,0.0788311,-0.031530287,0.023935119,0.036775164,-0.042476524,-0.011836778,0.0022463023,0.07584061,-0.047934286,0.12742542,0.0909428,-0.035730094,-0.0523214,-0.098964036,-0.017688919,0.014091409,0.04564283,-0.048538126,-0.06518902,-0.04432405,0.040006164,0.026495054,-0.07587054,-0.037866987,0.023255043,-0.024407627,0.038559295,-0.001051824,-0.10424674,0.02841912,0.04441974,0.085637696,0.069203265,-0.04858633,0.076398216,-0.0061871377,-0.108924896,0.045292407,-0.0048709046,0.0014543696,0.024031116,0.03500628,-0.056929275,0.040919855,-0.0048721833,-0.008644991,0.09373078,0.02096253,-0.028621035,-0.021808447,-0.047450777,0.046741724,-0.11864872,-0.040791284,0.032113016,-0.053316236,0.048886996,0.020362953,-0.073660426,0.017768158,0.06037346,-0.017804768,0.0014981987,-0.03732567,-0.09236622,-0.030284278,0.0084285615,0.039488655,-0.03309821,-0.10900419,0.008401773,0.07373692,-0.044107445,-0.11174079,-0.08918665,0.05387606,0.029816687,-2.448997e-33,0.08972815,-0.054457955,0.049721938,-0.048207656,-0.058353666,0.06402342,-0.042731814,-0.029597705,0.030326838,-0.025373776,0.029483749,-0.017358033,-0.07375498,0.018852314,-0.036441147,-0.0032995383,0.00047592135,0.070321515,-0.046555366,0.03808286,0.04735494,0.043449294,-0.023758078,0.027121233,0.0708875,-0.032249715,0.045643426,0.052960284,0.052340273,0.008681406,0.058410563,-0.029408233,-0.006923419,-0.062686056,-0.05118773,0.109022275,-0.07690416,-0.0019104864,0.015331413,0.0108216,0.027484003,0.00888024,0.006410963,0.07993041,0.04694104,0.022623938,-0.075442396,0.03969355,0.03051573,-0.028157523,-0.0023715051,0.03935407,0.061520208,-0.0055480045,0.028082188,0.0074852398,0.023799563,0.01872759,-0.008887504,-0.033405527,0.00525123,-0.058431722,0.04739066,-8.957176e-05,0.081655696,-0.053222306,-0.03842826,0.08100704,0.04720421,-0.001392037,0.020062719,0.0007842752,-0.06417965,0.028306069,-0.082376234,-0.05856757,-0.08189906,-0.01716365,0.053927034,0.068398625,0.010395942,0.0029875773,-0.00060218835,0.004132804,-0.07606733,-0.091350354,0.035443176,0.075348586,0.006127354,0.024131091,-0.004197654,0.013335689,-0.009118025,-0.0074907667,0.008589936,-2.7124406e-08,0.05874163,-0.043851323,0.060607623,-0.04912371,0.008507915,-0.0854624,-0.015010382,-0.007028837,-0.016959047,-0.055871204,-0.03856538,0.045685917,0.033711832,-0.017994737,-0.011356845,0.011338094,-0.09335742,-0.03659748,-0.009096275,0.031339094,-0.054862313,-0.052162893,-0.13276297,0.023098709,0.07820974,-0.1034921,0.0714814,0.036839303,-0.030089019,0.07963943,0.048773836,-0.013719054,-0.042563304,-0.028879227,-0.03312293,-0.036188148,-0.07433356,-0.06533919,0.04047412,-0.055058796,0.0010181686,-0.003864618,-0.02216157,0.040738903,-0.056039464,0.028509747,-0.026119428,0.006852928,-0.042308874,-0.00019458568,0.029992225,-0.013545317,-0.05386681,-0.028751856,-0.042334616,0.024457244,-0.020212334,-0.03025977,-0.043573264,-0.057941165,-0.01204391,0.006583776,0.21094802,-0.06789863 +6.3.4.23,"This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase.",384,1.0,-0.06029363,0.004062787,-0.13093476,-0.048827194,0.001330874,0.00766918,-0.116168134,0.03339913,0.0041628336,0.0071942704,-0.048252653,-0.09449422,-0.097650096,0.03965654,-0.06926219,0.03286941,-0.08724457,0.045735642,0.09247734,0.006102179,0.09015411,0.10801492,-0.0011650843,-0.00990125,0.037489884,0.0278572,0.05997261,-0.01007824,0.005150865,-0.013402383,0.024196625,-0.09148236,0.10554496,-0.078957275,0.15198441,0.06268331,-0.025534386,-0.034066465,0.073382445,0.003959894,0.036112264,-0.0027419415,0.100905925,0.01694258,-0.046902936,0.0040703868,0.003062781,0.040974323,0.06270896,-0.0767691,-0.057563562,-0.029452877,-0.06110376,-0.013070466,0.023989985,0.050673362,-0.06299912,-0.08248069,-0.004178268,-0.009559061,0.008675061,0.04702118,0.0028225551,0.00080542255,0.0032077555,-0.033569664,0.042213455,-0.10645178,0.10308714,-0.046595823,-0.041949093,0.0019609865,-0.035714243,0.027684305,-0.06027222,-0.021268707,0.0077324305,-0.014805899,0.052981142,-0.021221887,0.0056297923,0.009040318,-0.003749663,-0.031441256,-0.006072581,0.0006332924,-0.0021683746,0.04012429,0.05401566,-0.029800639,-0.0081218695,0.0027575584,0.043242827,-0.08845335,-0.060739543,-0.007982996,0.044971857,0.10287654,0.055015936,0.006970363,0.04548908,0.07074244,-0.05280676,-0.10435411,-0.027746735,-0.004951627,0.012071511,0.0797398,-0.013020663,0.07232241,0.01946046,-0.03817373,0.016369525,0.011617041,0.0067907055,0.034443855,-0.045051824,-0.0969807,-0.05730646,0.050864294,-0.006856823,-0.11883811,0.054572638,0.030241266,-0.06093857,0.040608183,-0.042821158,5.73127e-33,0.052341737,0.038187753,-0.003718663,-0.032371953,0.0036943643,0.0020721077,-0.084684215,0.030157298,-0.022799443,-0.03784187,-0.07101379,-0.03318194,0.03934437,0.032324046,-0.013265858,-0.046982896,0.0007066363,0.053021997,0.033750866,0.02385965,-0.031136466,0.096854486,0.020479191,-0.015571779,0.06256102,0.00982059,-0.006527184,0.008851426,0.044760983,-0.0056694914,0.046660747,-0.1171446,-0.12014004,-0.023890145,0.05948307,-0.011398431,-0.041762657,-0.059585206,-0.02430755,0.047635615,-0.043073628,0.0026340247,-0.020049697,-0.04812393,0.06410296,0.045917228,-0.010635862,0.07622924,0.0029831452,0.026093572,-0.009866357,0.008117306,0.064994745,0.016788982,-0.053362083,-0.036833934,-0.0012371426,-0.05795788,0.055754162,0.058369145,-0.018509062,0.04952513,-0.022647388,0.022195345,-0.0229941,-0.033758588,-0.016009554,-0.062006433,0.04655574,0.099681646,-0.0019858533,-0.05507215,-0.0108190095,0.05477573,0.03084295,-0.06168891,-0.006161166,-0.013148864,0.006172415,-0.020493617,0.014716258,0.051328912,0.028900174,-0.012898092,0.021484593,0.041513078,-0.0641879,-0.024558004,-0.045046736,0.06037352,0.016443178,-0.121079154,-0.066936865,0.048905108,0.040029064,-5.8909808e-33,0.05125476,-0.113704026,-0.03563068,-0.10893692,-0.07091616,0.046463635,0.0055267103,0.022464983,0.058674295,-0.02426522,0.06540868,-0.018814106,0.060538962,-0.051603492,0.045514207,-0.07246643,0.071885705,0.07702561,0.014003063,0.033553313,0.071124405,0.06846434,-0.050783746,-0.040024273,0.03136312,-0.01672117,-0.02096644,0.08684354,0.0003840293,0.041265912,0.0056314315,0.022753552,-0.04446871,-0.03187617,-0.097424164,0.04265213,-0.03239243,-0.004298525,0.013143727,-0.007894924,0.01450778,0.12320644,-0.018810434,0.012159432,0.025369596,0.058183026,-0.11101747,0.03700303,0.014073645,-0.087392725,0.012769634,-0.027626159,0.03045401,-0.029944923,0.0119015705,0.05991475,-0.028970992,0.013541403,0.019187344,-0.029757576,-0.041126657,-0.08470721,0.08207468,-0.016966196,0.085624926,0.055356197,-0.008093139,0.03139964,-0.028157763,-0.035586335,0.012514685,-0.011706962,0.006778054,0.10523641,-0.021439672,-0.027846595,-0.04574712,-0.015312704,0.052247822,-0.032847643,0.018950997,-0.06303021,0.033575527,-0.010292701,0.0035156286,-0.024266452,0.09936101,0.03759767,-0.044657554,0.083132654,0.03910104,0.017412614,-0.046959914,0.047923423,0.025170466,-4.141877e-08,0.058180705,-0.07987018,0.051374644,-0.085837446,-0.0068857786,0.05221308,0.03296403,-0.012040326,0.055914424,-0.04085604,0.04909223,0.039521795,0.0057451604,0.011387816,0.016258989,0.10124039,-0.07165215,-0.0041240593,-0.03296299,0.03734384,-0.023165481,0.019852985,-0.10120252,0.030972516,-0.020294802,-0.020306194,0.075914636,0.087188944,-0.02752279,-0.038268127,-0.034042563,0.029508652,-0.013270871,-0.015588543,-0.08034403,0.0045705824,-0.019685464,-0.05237488,-0.044043574,-0.0016569981,0.025769986,0.006180085,-0.03670713,0.022484181,-0.0011433631,-0.019740935,-0.04186981,0.044094887,-0.066824585,-0.05639633,0.013711311,-0.014966783,0.022282341,-0.08435113,-0.06391779,-0.058277175,-0.06505034,-0.06815131,-0.06594273,0.03434121,0.0785925,0.0011988478,0.19249314,0.022362454 +5.5.1.22,Requires Mg2+. The enzyme from Tanacetum vulgare (tansy) can also use (3S)-linalyl diphosphate or more slowly neryl diphosphate in vitro. The reaction proceeds via isomeration of geranyl diphosphate to (3S)-linalyl diphosphate [3]. The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (-)-bornyl diphosphate [4]. cf. EC 5.5.1.8 (+)-bornyl diphosphate synthase.,384,1.0,-0.07284573,-0.021186614,-0.017900182,0.00081551564,0.022112371,-0.016225731,0.0017499065,-0.008726687,-0.010934604,0.030566905,0.049662903,-0.041986454,-0.0011123677,-0.0153048765,0.0031200876,-0.01287668,0.017900936,0.043509286,0.035356198,-0.044535022,0.03530927,-7.197098e-05,0.005356987,-0.06286074,0.053456225,-0.03637463,0.09563781,-0.0429861,0.005481451,-0.07121495,-0.07937753,0.011536678,0.0016526548,-0.16653727,0.004745236,0.0691658,-0.06947497,-0.082940966,0.015809005,0.027847614,0.0669522,-0.04449827,0.02772807,-0.0080818795,-0.032073673,-0.03234866,0.06645765,-0.030003529,0.06363798,0.010689115,-0.0889952,-0.023174558,-0.045934774,-0.036394462,-0.054637704,-0.08551744,-0.047872663,0.04787206,-0.053610235,0.0011741176,0.028738836,-0.0010506978,-0.055608053,-0.07231389,0.031627536,-0.0013997991,0.040149454,-0.03615697,0.05599231,-0.027749144,-0.078804575,-0.03757411,-0.022059113,0.08014226,-0.10987825,0.07691349,0.025714656,0.059174165,0.026736245,-0.026197147,0.035685726,0.08049869,-0.007238749,0.04112274,0.017876264,0.061849587,-0.030222677,0.10713065,0.053579856,-0.013251811,0.05144528,0.08043121,-0.059038185,-0.03928964,-0.04924085,0.04655075,-0.031630352,0.054481216,-0.052584313,-0.038704995,0.038903292,0.08221256,-0.039318465,0.029095711,-0.056342196,0.017840829,-0.07717297,-0.019253105,0.0050219614,0.006357991,-0.0070484923,-0.010771895,0.052125227,-0.013362891,-0.029594813,0.0938396,-0.0056826673,-0.07671489,-0.011257045,-0.023326235,0.084947765,-0.04120139,-0.012801934,0.09848341,-0.037527993,0.029629307,-0.034888703,7.224207e-33,0.041057196,0.116605334,0.035924725,0.06997907,-0.052090865,0.041943107,-0.034549586,-0.01074561,-0.12036963,0.028558465,-0.08045065,-0.09117071,0.092245676,-0.02007622,-0.041588437,7.032883e-05,0.029543316,0.04548966,0.068956606,-0.02203732,-0.03935042,0.10457401,-0.029468933,-0.03153207,-0.04057595,0.10093943,0.0060779145,-0.036537495,0.045642298,-0.034059893,0.10877316,-0.09121779,-0.006688007,0.018030455,0.04803378,-0.1272947,-0.040353637,-0.0564367,0.017989645,0.024046514,-0.08902484,0.075957745,-0.0076644,0.0489973,0.017458359,-0.07524974,-0.034476772,0.016495258,0.052474994,0.036499124,0.09428268,0.035299074,0.07211099,0.07212383,-0.0835051,0.027874628,-0.006625385,-0.0067834584,0.029025445,-0.0046447804,-0.0017841997,0.004558932,-0.0209003,-0.016890611,0.03304853,0.07755887,-0.11553696,0.0064648585,0.050923232,0.12471805,0.0049246945,-0.04856917,-0.05104452,0.0989916,-0.019327972,-0.014089043,0.0073730173,0.025343545,-0.015331289,-0.019033697,0.038044337,0.02175956,0.008615377,0.0030361062,-0.046998333,-0.015728079,-0.050214272,0.031238742,0.0139184045,0.04977588,0.065506,-0.0036347692,-0.078220055,0.020426463,-0.038831435,-6.0012337e-33,0.11532472,-0.036462143,-0.1078389,-0.113188796,-0.101821125,-0.026744595,0.046983432,-0.06566195,0.0068295184,0.013614011,0.054039,0.013158637,0.076596305,-0.043363567,-0.05663663,0.016758727,-0.006801818,0.1112438,-0.0474017,-0.034208708,0.021755358,0.046700705,0.050620314,0.009244383,-0.0019534468,0.012131111,0.051826693,0.03347809,0.040830437,0.070533894,0.018148076,0.033601236,-0.051447198,-0.061156712,0.019759858,0.043640606,0.005089439,0.03481501,0.019870784,0.041051622,0.007212104,0.039938666,0.0752742,0.0265724,0.077936515,0.032315444,-0.046932906,0.035679877,-0.082190864,-0.06386079,-0.015829869,-0.01569441,-0.00092894235,-0.01762326,0.037031967,-0.021181148,0.04263001,-0.032405417,0.034743994,-0.06394697,0.018453442,-0.036860272,0.036749,-0.06620362,0.017345002,0.11856189,0.01035061,0.08044849,-0.01689775,0.050027348,0.027966825,0.044923857,0.04715621,-0.0036813256,-0.052409694,0.03231447,0.021310652,0.04761921,0.06299965,-0.08494449,0.010238854,0.028873581,-0.0017186361,-0.08679357,-0.047711883,-0.026065763,0.0039304467,0.11158778,0.053398013,-0.007805147,-0.08086218,-0.04887167,-0.05815975,0.04817591,0.112099476,-4.747624e-08,-0.008148665,-0.034598935,0.0012998763,0.021844743,-0.05479901,0.09278293,-0.018109398,1.0569596e-05,0.04755007,-0.002029382,-0.06616932,0.027420387,0.011392594,-0.033724837,0.021645805,0.065838456,0.015034631,0.04412266,-0.0394176,-0.044396438,0.04693202,0.0021795284,-0.049836762,0.08080502,0.020702729,-0.07979021,0.017127737,0.01580491,0.016655752,-0.06421222,-0.00966684,-0.02801873,0.007902072,-0.0016555381,0.0034581008,0.038569186,-0.1207943,0.020408856,0.0031986102,-0.06501537,-0.10926324,-0.015726352,-0.021028807,0.010331567,-0.053493172,-0.01898069,0.012240482,-0.054320112,-0.027760029,-0.008394303,0.05378522,-0.029050803,-0.027057748,-0.038369745,-0.07772404,-0.026211526,-0.013349971,-0.004242421,-0.031777777,-0.056755632,-0.046620447,-0.0036466063,0.11777751,-0.014408602 +1.1.1.361,"The enzyme, found in the bacterium Bacillus subtilis, is involved in a kanosamine biosynthesis pathway.",384,0.99999994,-0.02729766,-0.022195483,-0.06184839,0.012205773,0.024811052,0.02416953,-0.065047905,0.032664005,0.0069655958,0.03166995,0.03054167,-0.101115145,0.019491555,0.028315384,-0.053142134,0.07115413,-0.09423527,-0.039570276,0.03894605,-0.018301627,0.11892132,0.062070917,-0.016791167,0.0029766134,0.003917916,-0.038179964,0.081106775,-0.084021404,-0.030168047,-0.0038196351,-0.06024361,-0.022217998,0.09065535,-0.059815805,0.07364942,0.06895399,0.013293974,-0.0067652646,0.11003196,0.011432555,-0.005398115,0.0021317939,0.0038532976,-0.014734784,-0.0032521011,0.043146096,0.07342482,-0.026454799,0.0029037925,-0.00946868,-0.07250105,0.00053796143,-0.024486408,0.023349497,0.052922368,-0.006189543,-0.028876396,-0.026786651,0.039467953,-0.0020201036,0.06435435,-0.0006553836,0.025939876,-0.034539204,0.0064623435,-0.097371,0.040407386,-0.018202394,-0.0016251762,-0.057689417,0.008335318,-0.05304784,-0.026642581,-0.0032872602,-0.009771776,0.0077775526,-0.00082693796,-0.015678287,-0.0011741617,-0.06683543,0.019944953,0.012488005,0.054183297,0.08189339,0.034944218,0.024201509,0.09950588,-0.077232465,0.06682441,0.06678509,-0.00029652045,-0.11855523,0.0009826629,-0.06470024,-0.07232143,-0.0725055,0.02865412,0.016633768,0.108236596,-0.02249296,-0.009115852,0.02054823,-0.022943515,-0.071385175,-0.07255053,-0.031456865,0.054625727,0.070940636,0.09001296,0.018490799,0.0045811147,0.051736075,0.04293646,0.02119248,-0.010066931,0.085936494,0.06770785,-0.056508522,-0.052407354,0.05845527,0.010854799,-0.01139406,0.013920349,0.08779482,-0.08292334,0.015727298,-0.124030754,-2.9085943e-34,0.025510998,0.008946986,0.036367018,-0.016104067,0.035427425,-0.056893323,-0.08862506,-0.078752995,-0.08249851,-0.093622595,-0.10493665,-0.078537144,0.0126811685,0.07872411,-0.008676523,0.010385979,-0.05556827,-0.020228866,0.04450218,-0.024123847,-0.036123347,0.02741441,-0.080306284,-0.031467456,0.001262254,0.022879869,0.0788474,0.014290074,0.044350814,-0.010539639,0.067483306,-0.049940497,-0.06724617,-0.003832535,0.045500956,-0.016913781,0.010095148,0.0015297749,-0.06887499,0.013383078,0.0069640875,0.051892336,-0.048046324,-0.027508339,0.034327965,-0.07222725,-0.013987979,0.061700553,0.060990613,0.076351225,-0.03385061,0.018245667,0.14881755,-0.043708704,-0.042235926,0.036570005,0.0016144012,-0.07056896,0.039085407,0.034777902,0.009352822,-0.009373347,-0.034525998,0.056443226,0.01488964,0.038602773,-0.03901443,-0.023124525,0.043318022,-0.011480713,-0.09990166,0.014816986,-0.0007565904,-0.008059533,-0.0593365,-0.0073244898,-0.08878396,-0.012365618,-0.06287584,-0.021795236,-0.04415251,-0.03756939,0.013882889,-0.03744132,-0.036670227,0.039923213,-0.04683263,-0.0898926,-0.039236687,0.07634853,0.046011593,-0.10281352,-0.0865107,0.051825568,0.0039886967,-1.1309665e-33,0.10397536,-0.0938513,0.05541853,-0.09432467,-0.040378384,0.00584634,0.046146292,-0.042512987,0.0289641,-0.0072555537,-0.012932718,0.013394517,0.033612516,0.0040518846,0.027925747,0.026350854,0.04840904,0.066319056,0.035133433,-0.007360951,-0.016779661,0.10000862,-0.03720354,-0.0545931,-0.010295141,0.07053627,-0.038018584,0.14029658,0.005819934,-0.014948109,-0.05317303,-0.014290167,-0.015100769,-0.03722363,-0.055573266,0.011521654,-0.019203365,0.0026215557,0.056947272,-0.012653973,0.010441805,0.09166647,-0.028397582,0.03818126,0.01751461,0.042553257,9.786936e-05,0.05054442,0.021361612,-0.07889222,0.004988658,-0.03817568,0.054102838,-0.06006561,0.04497317,0.028797725,-0.063620776,0.057844553,-0.023659421,-0.065065995,0.00039246108,-0.006090996,0.091006964,0.0077059492,0.027480165,0.11437043,-0.00059325184,0.037006583,0.03305984,-0.08668139,0.036277033,0.05888152,0.03271168,0.054820314,-0.05187122,-0.08111227,-0.12343358,-0.0628357,-0.0073780725,-0.032652956,-0.0064753434,-0.040569235,0.005819266,-0.08157473,-0.036820352,0.019316196,0.0287911,0.0924638,0.025475224,-0.00836919,-0.049562164,-0.029628336,-7.574473e-05,0.07152725,0.059779644,-2.7442427e-08,0.05219195,-0.08300468,0.008953387,-0.024564598,-0.020251174,0.024927897,0.0047104396,0.025462002,0.035099436,-0.057041965,-0.0056868875,0.0747247,0.030607762,0.01237728,0.04245589,0.009596095,0.00065492425,-0.019261079,-0.03162942,-0.024059841,-0.07820832,0.012504054,-0.049831852,0.11003728,0.02655558,-0.04755469,-0.0021692885,0.054826528,-0.011464757,-0.08945968,-0.03092548,0.06836542,-0.032868713,-0.03305145,-0.06762433,0.033686105,-0.093872644,0.0011136507,0.017818477,0.033052593,0.09873048,-0.00045963016,-0.03034634,0.026185226,0.019241858,0.0774441,-0.027889447,0.027552472,-0.020054078,-0.058191847,0.021325784,0.031881083,-0.004934672,0.048075404,-0.09727067,0.028488819,-0.040177338,-0.04568681,-0.033105176,0.00673364,0.0004980171,0.033757437,0.17813514,-0.075868 +1.1.1.362,"The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin. 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The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP+ while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD+. cf. EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+) and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+). ",384,1.0,-0.08472219,0.0036690212,-0.03634758,-0.05657532,0.01755582,0.022550432,-0.06098521,0.04519548,0.054664135,0.040753867,0.018389601,0.0046556317,-0.073597774,0.021086413,-0.06863898,0.004448671,-0.016462348,-0.0053596105,0.059934083,-0.032426447,0.1286632,-0.008099298,-0.011237727,-0.105828755,0.119294815,0.023861133,0.05670831,0.0065821856,0.029479906,-0.08160654,-0.078917846,-0.068505965,0.017285075,-0.12180304,0.05962087,0.071456246,-0.01065058,-0.04985892,0.04357229,0.03630902,0.006170484,0.015822226,-0.015787143,-0.04842672,-0.10129422,-0.04984653,-0.0061542597,0.13449523,-0.0075034685,-0.045121904,-0.06999272,-0.036319524,-0.031509478,0.010481258,0.052614402,-0.023090176,0.015136818,-0.019693935,-0.026077779,-0.07364178,-0.0048151445,0.00037658616,-0.014957499,0.0013676442,0.013251556,-0.10001537,0.033080563,-0.040787153,-0.019527625,-0.0048783673,-0.07401127,-0.014879006,-0.025437713,-0.011559258,-0.033690292,0.048615918,-0.06672019,-0.010451115,0.021269534,0.019308878,0.022477435,0.025961205,-0.0057282774,0.08762735,0.061524,-0.075825654,0.009778242,0.06864413,0.03800634,0.028330803,-0.018801717,-0.075680055,-0.028115207,-0.016920617,-0.10745827,0.0124231605,0.013224204,0.021668313,0.031225258,-0.07649516,0.032569557,0.04433845,0.013168265,-0.06432222,-0.02316386,0.03693226,-0.06328014,0.1692664,0.04449428,-0.030716712,-0.028027978,0.007321537,0.0065819332,0.019988822,-0.06463673,0.036613766,-0.0039466363,-0.047215816,-0.053448994,0.037237193,-0.018345952,-0.013740692,0.0059771654,0.05670514,-0.014741532,0.0930404,-0.10178401,2.1004336e-33,0.044917796,-0.0024352716,-0.0077832215,-0.08574277,-0.0047257524,0.054576814,-0.049559504,0.09209,-0.046539307,-0.02787607,-0.04319991,-0.07175377,0.04462604,-0.006642482,-0.034218527,0.034515206,-0.035233133,-0.027682794,0.017244395,0.09414986,0.034079343,0.04619418,-0.005609877,0.002468516,0.08536395,0.04760726,-0.014514213,0.043320525,-0.05433092,-0.006546213,0.074072205,-0.13047624,-0.09753194,-0.006146066,0.08815123,-0.0015916855,0.010665889,-0.09282864,-0.039333455,0.012544609,-0.08804217,0.04111953,0.020386744,-0.033481658,0.08335705,-0.011788513,0.001464449,0.03160019,0.04502999,0.06572717,0.0325317,0.0040204157,0.09523622,0.010106823,-0.045334917,0.03420065,-0.04755716,0.035017848,-0.0014637405,0.082710594,0.037063703,0.062377203,-0.04297706,0.014702519,0.013421326,0.01547824,-0.05668157,-0.051343866,0.035488307,0.12623177,-0.0828995,-0.008681348,0.03752551,0.01403949,0.024399733,-0.040854402,-0.014035838,4.33065e-06,0.029678473,-0.020681256,0.026008746,-0.049323045,-0.04221522,-0.10351895,-0.0796578,0.027660834,-0.06704972,-0.04784911,0.041189063,0.053041343,0.040487736,-0.025391573,-0.07340004,0.06316134,-0.013249996,-2.895124e-33,0.10495221,-0.059644833,0.077017345,-0.04953724,-0.07765694,0.07708496,0.037985843,-0.06490376,0.026739249,-0.029097771,0.030793391,0.031592283,0.025306959,-0.007318172,0.0022832374,-0.023588339,-0.00076497725,0.06668175,0.016388891,-0.027196947,-0.045935173,0.14838031,-0.006471032,-0.029778516,0.010340314,-0.03537432,-0.0010309746,0.060439516,-0.019567892,0.032903478,0.03417044,0.047742266,-0.025999794,-0.018838186,-0.06452679,-0.0173023,-0.10113463,-0.0037041672,0.07695213,0.09300388,0.051402878,0.05609069,0.013797429,0.028789423,0.015460278,0.023600847,-0.1064532,0.030931195,0.032364782,-0.045277394,0.0050207437,-0.002032586,-0.013459264,-0.01043528,0.019852895,0.012727931,-0.003078676,-0.0037979328,0.026014341,0.018686997,-0.035403624,-0.018813625,0.1083222,-0.031340096,0.06370223,0.030449202,0.026421454,0.083065875,0.033477046,0.016216801,-0.012518733,0.0037342883,0.0013291053,0.026317926,0.01710985,0.014105992,-0.11390195,-0.025731444,0.00893844,-0.09087777,0.011571245,-0.01203014,-0.021334438,-0.0758889,0.00043519717,0.041616805,-0.013436878,0.059515893,-0.0038482423,0.051355507,-0.027020104,0.031882133,0.0067138365,0.0077884304,0.062194858,-3.7954035e-08,0.01949767,-0.0030023472,0.030381002,0.02793019,0.024868486,0.0025070426,0.012719371,-0.0022129328,0.09488483,0.07665521,0.015057486,0.11181693,0.008560797,-0.018567566,0.02010119,0.021215355,-0.028163893,-0.07316472,-0.0031082805,0.025033534,-0.05875105,-0.045006715,-0.13270764,0.08353153,0.063191764,-0.086066775,0.06336442,0.033215515,0.05313756,0.0012245033,-0.03515795,0.062461793,0.003060206,-0.030467205,-0.032981023,0.023973372,-0.08007117,-0.026415752,0.023027217,0.008819307,0.042905662,-0.048402555,-0.05399029,-0.04276425,-0.042952336,0.060121354,0.03134547,-0.017590372,-0.11466504,0.02960098,0.03097249,-0.055470496,0.003165683,-0.008287453,-0.005760556,-0.024303475,-0.02406485,-0.07851377,-0.0089507075,0.0017987951,0.061075095,0.03082141,0.18289919,-0.030754982 +1.1.3.45,"A flavoprotein (FAD). This bifunctional enzyme is a secreted flavin-dependent enzyme that is involved in the modification of the terminal sugar residues in the biosynthesis of aclacinomycins. The enzyme utilizes the same active site to catalyse the oxidation of the rhodinose moiety of aclacinomycin N to the cinerulose A moiety of aclacinomycin A and the oxidation of the latter to the L-aculose moiety of aclacinomycin Y (cf. EC 1.3.3.14, aclacinomycin A oxidase). ",384,1.0,-0.103093736,-0.03460334,-0.1619583,-0.007155507,0.06310447,-0.011969834,0.013807787,0.09363917,0.10424662,-0.04077163,0.0329185,0.05277365,0.035841353,0.0071897707,-0.075893484,0.017810851,-0.09297341,-0.019488243,-0.067214824,-0.036488447,0.034151133,0.012833464,0.04807655,0.0008378818,0.050984807,-0.07542195,-0.008263476,-0.0023577516,-0.06667333,-0.012935345,0.12611319,0.019037986,0.006343897,0.015905105,0.009416949,0.06404903,0.024692353,-0.044118866,0.098255105,0.02872827,-0.015597347,-0.03673523,0.02988639,0.024767715,0.04677427,-0.001209333,-0.08130536,0.03284089,0.0048181475,0.098696634,-0.0384137,-0.029485999,-0.09072263,0.034138158,0.060146227,0.03549011,-0.009257199,-0.0852152,-0.021112852,0.026983097,0.03910718,-0.047699228,0.019517373,0.047868572,-0.045033094,-0.12849836,-0.008686387,-0.06334983,0.057232667,-0.027105665,-0.032091584,-0.04679512,-0.028865295,0.010959514,0.035083264,-0.029729301,-0.056898974,-0.026850805,-0.010617084,-0.012238805,0.0794335,-0.0041859993,0.09425006,0.10068838,0.07397249,-0.0677454,0.043193948,-0.012519582,0.025501644,0.1152235,0.006869821,0.034539036,0.009528443,-0.030121721,-0.054444227,0.022379179,0.057790205,-0.05671071,-0.06157886,-0.019061532,-0.029343097,-0.0015912816,0.042441417,-0.025134668,-0.061366685,-0.025143104,-0.03608366,0.06478905,-0.030451816,-0.045186892,0.0042618206,-0.055038016,0.012081716,-0.10386356,-0.037818015,0.11803945,0.0022828104,-0.06947919,-0.063801266,-0.03648168,-0.078085296,0.08241695,0.010621253,0.08768512,0.037806384,0.0018996329,-0.10053247,2.8820629e-33,0.031466696,0.04736447,-0.07064112,-0.02054799,0.03420272,-0.018320186,-0.044498056,-0.004696445,0.02790867,-0.0059210695,-0.041546643,-0.020087214,-0.0006317495,-0.040750753,-0.0088775,-0.012230432,-0.015810782,-0.045907553,0.030119948,-0.038035907,0.043196272,0.012750974,0.033532646,0.034879018,0.040977318,0.027423454,-0.070624605,0.044264503,0.03189965,0.016791115,-0.0028882406,-0.027933866,-0.05055731,-0.009569857,0.023273425,0.015225867,-0.08360675,-0.06908266,-0.014480706,0.099765606,0.0049689757,-0.04316553,0.02403712,-0.01589409,0.050487492,-0.00552085,-0.09585685,0.11869943,0.0385165,0.098986864,0.04233533,-0.031815298,0.097596504,0.041796606,-0.0788916,0.05505125,-0.06698091,-0.009377747,0.029352058,-0.02208367,0.03486264,0.025697641,-0.016795877,0.016043896,-0.07065495,-0.00016102137,0.020968499,-0.06743738,0.015749201,0.09180348,-0.0041165235,-0.013893586,0.0761849,-0.010667566,0.12638968,0.006942407,-0.058559936,-0.016664417,0.0018745391,0.036330633,-0.039888192,0.0101095615,-0.009986303,-0.037793953,-0.023772458,-0.027844753,-0.02244706,-0.04293013,0.027963959,0.015245314,-0.016699044,-0.092741266,-0.0049876897,0.0023960732,0.05556348,-3.5878784e-33,0.07718213,-0.111771844,0.081405245,-0.022301802,0.015812345,0.009311602,-0.0040962636,-0.005902452,0.015205149,-0.026709784,0.0050039818,-0.021821529,-0.077270895,-0.027289791,0.04186538,0.01947146,-0.04998441,0.072549544,0.0044053076,0.05593948,-0.04911032,0.032862823,0.04651785,0.07467434,0.018846493,0.012771437,0.011984571,-0.0382577,0.061983436,0.044256307,-0.061921727,-0.022198094,-0.043878376,-0.040586755,-0.062262334,0.033506416,-0.028042557,0.016732408,-0.011143453,0.031702414,0.04925429,0.0049665766,-0.035001475,0.021161374,0.036944546,0.035920497,-0.04426286,0.030971508,0.04856109,-0.10372792,0.022043183,0.059379227,0.009891068,0.040020995,0.04173906,0.07474006,0.029003816,0.0524189,-0.0055624708,-0.03396084,-0.007951481,-0.10691196,0.007592246,0.02434306,0.07472609,0.097271405,0.012975016,0.08641833,0.02175282,0.025309484,0.06808348,0.003090172,-0.004109136,0.017976776,0.050147373,-0.039197262,-0.049676448,-0.01918519,-0.009133565,0.03067274,0.00757743,0.005249202,-0.004322334,0.011033759,-0.09104091,-0.063870884,0.02693825,0.040853206,-0.01268068,-0.013289489,-0.004965688,0.053684965,0.029245177,-0.021311386,0.06721518,-3.9042302e-08,0.033462726,-0.012855376,0.045482494,-0.04406993,0.110175475,0.027663384,-0.0833427,-0.050487556,0.020137563,-0.02385623,-0.06465468,0.15989465,-0.011707955,-0.045348324,-0.016365573,-0.022370586,-0.047972813,0.034632675,0.014476115,0.023339955,-0.09363052,0.046644572,-0.101673625,0.026675591,-0.01736292,-0.013921359,-0.014340971,-0.030462027,0.015318823,0.006847862,0.028496932,0.038894884,-0.021561839,-0.03242915,-0.14299525,-0.022104742,0.0353233,-0.114510864,-0.024785785,0.010389676,-0.009498938,-0.033442598,-0.03286283,-0.008907065,-0.040404007,-0.00038172025,0.056164745,-0.057209186,-0.07488287,0.026269699,0.024379758,0.0050242003,-0.0364933,-0.033947337,-0.06539619,-0.03772059,-0.011399878,-0.08166724,-0.053395033,-0.07323968,-0.037385494,0.015061128,0.2115703,-0.03216791 +1.2.7.11,"Contains thiamine diphosphate and [4Fe-4S] clusters [2]. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For example, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).",384,0.99999994,-0.02752035,-0.004763644,-0.10914023,-0.0136799505,0.103834055,-0.027334882,-0.078235164,0.008050904,-0.0384218,-0.06664152,-0.0058405306,-0.08979597,-0.004406453,0.0012591693,-0.06739042,0.004315845,-0.040593155,-0.021154732,0.026383959,-0.04302157,0.005065696,0.066350676,-0.004012106,-0.013343464,-0.014466833,0.08410325,0.077299945,-0.04506159,-0.035666738,-0.0948774,-0.061862346,-0.0012829101,0.070395276,-0.045113858,-0.0048055626,0.08623614,0.007832712,-0.012277901,0.04480733,0.03445168,0.01431005,-0.005351636,0.0020859395,-0.04049112,-0.06107916,-0.06644105,0.021507092,-0.0026447156,-0.014428091,0.040836524,-0.02933101,-0.020530613,-0.04064935,0.089427836,0.047202993,-0.07354795,0.015619685,-3.3017208e-05,-0.06491621,0.05665282,0.06963776,-0.048053704,0.01447464,-0.00463657,0.0664065,-0.008263746,0.03890694,-0.06462942,-0.01573105,-0.13056639,-0.043953862,0.01600045,0.060135666,0.027921418,-0.062508285,0.06680787,0.061951168,-0.021010589,0.07215915,-0.009052368,-0.005832508,0.017524594,0.050278082,0.072592825,0.032084793,-0.0063024634,-0.052677114,-0.05050574,0.028811174,-0.001809636,0.047174618,0.038657572,-0.051738743,-0.004572213,-0.024487372,0.08150904,0.01863981,0.048275005,0.027658887,-0.0084876185,-0.013417152,0.08659651,-0.046387013,-0.05646813,-0.056011364,-0.0069401604,-0.023281569,0.07011899,0.013807423,0.042412315,0.00711088,-0.01242782,0.012217684,0.046701696,-0.026256524,0.05351974,0.03304719,0.0010121216,-0.07639484,-0.00986976,0.026576212,0.023758668,0.09001615,0.04258103,0.025775982,-0.022941211,-0.16410297,3.1762544e-33,0.11188627,0.030358445,0.02123197,0.004628286,0.013046508,-0.012111752,-0.07300788,0.06482132,-0.025673367,0.009609471,-0.05334137,-0.024613542,0.11764525,-0.029995525,0.001098304,-0.13841099,-0.030034812,-0.024966767,0.0806355,-0.01062136,0.0038817714,0.104516886,-0.062166702,0.0335636,-0.060135055,0.069342054,-0.010488272,0.042357218,0.040980693,0.03512087,0.0112783015,-0.08912713,-0.10080253,-0.07565844,0.03737265,-0.06945554,-0.09315515,-0.018765926,-0.090052135,0.0198463,0.02072466,-0.013013857,-0.0144809745,-0.085349955,0.060927756,-0.1055468,-0.034317993,0.084323294,0.017994467,0.05980406,-0.029495414,-0.032056984,0.0922623,-0.07095789,-0.06679514,-0.0120134065,-0.047001462,0.014234164,0.08737451,0.054014076,0.035524815,0.030801944,-0.063859254,0.021940522,-0.0359175,-0.010914799,-0.05547062,-0.04250086,0.00554793,0.07165017,0.056359183,0.013471017,0.08056491,0.020646548,0.033811066,-0.07153239,-0.00666541,0.07897627,0.05860588,-0.043224536,0.036748547,0.0106810825,-0.012874065,-0.05619202,-0.0023587516,-0.02601312,0.004986921,-0.03733855,-0.051540572,0.05119258,0.003303262,-0.010020346,-0.067035384,-0.054517,0.0610132,-3.7006972e-33,0.10563531,-0.07566034,-0.003219567,-0.10803888,-0.053401746,-0.009219135,0.041660164,0.017793184,0.008166784,-0.008792496,0.09456117,0.0021695362,-0.02174774,-0.08679536,0.0228288,0.07000232,-0.014633365,0.032080654,0.06514879,-0.0025033422,0.04242625,0.057620086,0.00984641,0.011278783,0.05811981,0.018069945,-0.01510728,0.031194055,0.054907225,0.09103708,-0.06212247,-0.012226563,-0.022748498,0.015224276,-0.098215826,0.02817478,-0.04937762,-0.03449875,0.031807825,0.03207378,-0.077434495,0.029244531,0.03212158,0.08823567,0.0716241,0.025470356,-0.059029423,0.04028902,-0.013348946,-0.031603552,0.02735011,-0.009200043,-0.058889847,0.0068164915,0.036878783,0.032029796,-0.008123398,0.043637086,0.008040982,-0.012528766,0.011783816,-0.125283,0.04318253,0.034682017,0.055031434,0.06808622,-0.031360947,0.027304245,0.05029369,0.046810552,0.062587135,-0.041661568,0.028196044,-0.029875029,-0.010620296,-0.06501403,-0.026952766,0.030198853,-0.07035284,-0.009149515,-0.009865816,-0.038787335,0.0036132454,-0.04164466,-0.044534378,-0.06498826,0.041166794,0.101152904,-0.008092828,0.04180691,-0.07088795,-0.0077315723,-0.028286371,0.067829624,0.04066436,-4.5379753e-08,-0.03304402,-0.11834366,0.023649357,-0.016272476,0.059138935,0.054208174,-0.021393292,0.018198697,0.053278316,-0.014083487,0.04322291,0.0885256,-0.017693937,0.016136542,0.10062494,-0.04945959,-0.027471988,0.055412892,-0.031524714,0.02739242,-0.017188968,-0.027213948,-0.05560162,0.033907812,0.01759449,-0.026130669,-0.0051968354,-0.07920964,-0.0099528115,-0.0580237,-0.00875133,0.038592655,0.035534568,-0.111173525,-0.08600069,0.007763687,-0.008654153,-0.04768613,-0.06913604,0.043889306,0.00059836113,-0.051514447,-0.058438912,0.034713164,0.044961415,0.013456351,-0.0008717258,0.076622404,-0.03410272,-0.0509334,-0.025919681,0.00093562587,0.011236201,-0.012280531,-0.07716572,0.030636813,-0.033610888,-0.03791493,0.033970825,-0.021156698,0.016381066,0.07431071,0.18603644,-0.039363194 +1.3.1.104,"The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)].",384,1.0,-0.06682268,-0.016555618,-0.069295436,-0.024693362,0.0003975788,0.0907665,-0.06078932,0.036096226,0.015878716,-0.07435266,0.06247471,-0.034495037,-0.061246153,0.0036790373,0.017114533,0.004713639,-0.006306138,0.026099086,-0.0033530719,-0.08328663,0.06598888,-0.030231621,-0.0156122465,-0.0027222205,0.0623487,-0.050939552,-0.0049111336,-0.025095792,-0.09234647,-0.11643036,-0.029949332,-0.039667644,0.022218106,-0.041226536,0.044661026,0.04165063,-0.055397872,-0.04350893,0.039000142,-0.020842435,0.009829674,-0.04117067,-0.07330335,-0.006419307,-0.020838816,-0.053229183,-0.08385318,0.064547636,-0.029390791,-0.01652318,-0.024050808,0.001824579,-0.03255049,0.025044214,0.029598702,0.043700278,0.030585688,0.008347313,-0.06133362,-0.028876336,0.073752426,-0.06584295,-0.009382881,0.015279183,-0.03898652,-0.05890177,0.076128595,-0.0787739,0.0017921054,-0.009785002,-0.0684629,-0.0615044,0.0005323774,0.006707164,0.029441886,0.050338864,-0.028488375,0.010144133,0.038631424,-0.026727626,0.05894575,0.027512286,-0.049432937,0.00040197623,0.09178048,-0.011886962,-0.012678767,-0.016936567,-0.03920796,0.031106457,-0.013359014,-0.047734477,-0.027682856,0.050548594,-0.1022462,0.03655006,-0.026770195,-0.008963531,-0.035456855,-0.047220495,0.059345197,0.069707505,0.016286673,-0.056847576,-0.07954291,-0.025207754,-0.030622816,0.10318651,-0.062161725,-0.026227828,0.002883076,-0.035915356,0.073304996,0.031542365,-0.062130734,0.15402885,-0.043928567,-0.02688308,-0.048143134,-0.029149061,-0.008536593,0.010638339,0.030166687,0.019101165,-0.009004734,-0.07244666,-0.13473494,3.719529e-35,0.06329629,0.012705791,-0.0096093025,0.0025904037,0.069494374,-0.012661697,-0.11812332,0.08221845,-0.044087555,-0.04407315,0.030123083,-0.0787544,0.060551196,0.011913693,-0.012250942,-0.029403342,0.010553117,0.05940886,0.0044133235,-0.019000497,-0.04545994,0.10356358,-0.017958438,-0.035462767,0.014185153,-0.02111264,-0.11259866,-0.005945586,0.0047431393,0.030192608,0.021822592,-0.0690431,-0.066152014,0.056446314,0.110788666,-0.012778509,0.03396429,-0.055882398,-0.014955285,0.054482926,0.006062436,0.08787376,-0.0017848874,-0.056780893,0.029369686,-0.047541726,-0.04342346,0.074441336,0.035387784,0.03534534,0.052893527,0.0013474441,0.10997936,-0.017091786,-0.020273479,0.04822468,-0.08323692,0.019136349,-0.034080774,0.047836445,0.06892333,0.059813693,-0.052323956,-0.0050827926,-0.057962965,0.021702442,-0.092303194,-0.048940245,-0.017128823,0.13128054,0.043797143,0.050802324,0.09172173,0.051242243,0.049269747,-0.040221877,-0.016473975,0.033794988,-0.018079031,0.034548536,-0.06809855,0.045460213,-0.023223558,-0.03909528,-0.100496165,-0.0012985064,0.0333557,-0.01915859,0.07981708,0.026458656,0.054407008,-0.022672249,-0.05463922,-0.0018213708,0.03307326,-1.777052e-33,0.08811334,-0.038927164,0.08554013,-0.14554965,-0.016714575,0.07519418,0.07213538,-0.030510973,0.0021211738,-0.055701535,0.06267117,0.06615039,0.02296212,-0.01354204,0.054595076,-0.0081213955,-0.028015591,-0.024405273,-0.015383766,-0.007841383,-0.0010430008,0.03890656,-1.7082866e-05,0.06315848,0.036209483,0.027765667,-0.04997807,0.1018179,0.030523814,0.008719119,-0.009038714,-0.013351499,-0.09072521,-0.017247325,-0.0044742757,0.08844736,-0.10194108,0.011897626,-0.030874362,0.07032951,-0.031141376,0.021251833,-0.04651161,-0.036324546,0.103089884,-0.00848443,-0.035830837,0.03353018,0.03944231,-0.15071292,0.05434532,0.040627006,-0.011729384,0.0043061334,0.027401125,0.08723587,-0.009226176,0.037897006,0.020367203,-0.03333843,-0.024678614,-0.030115617,0.0059478804,0.005825305,-0.00013990424,-0.006877878,0.023362655,-0.03148633,0.031896822,0.0004501657,0.04168742,0.062810816,-0.02020181,0.081828736,-0.03608724,-0.100428544,-0.057301693,-0.013566357,-0.068624884,-0.030173222,-0.030342825,-0.023440162,-0.033311762,-0.021462608,-9.960003e-05,0.0010784281,-0.0050357534,0.042681824,-0.00945143,0.018361093,-0.017711358,0.031961784,-0.10674229,0.1400473,0.030340368,-4.3432095e-08,0.10731871,-0.038270153,0.03296394,-0.021493776,-0.0191939,0.028711848,0.06223323,-0.078699976,0.036277566,-0.041853026,-0.054491214,0.14029406,0.062168166,0.0520142,-0.0049684993,0.030351548,-0.057608437,0.02468745,0.0015325126,-0.050213322,-0.04592273,0.0063262326,-0.08616584,0.012189051,-0.0062577995,-0.023236463,0.009764628,-0.0035443236,0.053174455,-0.033393227,0.05329974,-0.010181494,0.11741913,0.015428131,0.04814949,0.038995996,-0.05447339,0.012042681,-0.061047316,0.108500674,0.0123979505,-0.04074885,0.010957133,0.050305754,0.07262223,-0.0048833117,0.05361375,0.016939579,-0.039940357,0.009205966,-0.027471714,0.039013904,-0.0056069163,-0.037039377,-0.07352787,0.02012772,-0.051467624,-0.055187605,0.0041925553,0.007437571,0.010853033,0.022529475,0.13000064,-0.011096829 +1.3.3.14,A flavoprotein (FAD). This bifunctional enzyme is a secreted flavin-dependent enzyme that is involved in the modification of the terminal sugar residues in the biosynthesis of aclacinomycins. The enzyme utilizes the same active site to catalyse the oxidation of the rhodinose moiety of aclacinomycin N to the cinerulose A moiety of aclacinomycin A (cf. EC 1.1.3.45) and the oxidation of the latter to the L-aculose moiety of aclacinomycin Y.,384,1.0,-0.10184022,-0.03113042,-0.16843711,-0.011526559,0.05480735,-0.011539351,0.01801741,0.09682632,0.108651154,-0.035240088,0.025926262,0.053193834,0.025963727,0.0051659164,-0.07856225,0.01326873,-0.09469814,-0.019324386,-0.061538495,-0.030297436,0.028173586,0.0130211525,0.04647653,0.0043953178,0.05553685,-0.06898416,-0.0063504116,-0.00071613013,-0.06511332,-0.012779739,0.12497198,0.026945362,0.0058435868,0.011803665,0.007989729,0.066767186,0.011750634,-0.039826535,0.09716067,0.032514002,-0.0063370317,-0.034273557,0.030931594,0.029053137,0.052928552,-0.00042379543,-0.08455627,0.045419008,0.011079809,0.10045336,-0.040251642,-0.023446867,-0.094130725,0.038174435,0.061636735,0.027897453,-0.012544656,-0.077318266,-0.024879795,0.024512487,0.03390887,-0.043210853,0.027714223,0.045052946,-0.039590858,-0.13149032,-0.008568167,-0.0626072,0.06438581,-0.021056743,-0.030997725,-0.039650295,-0.038263984,0.013978557,0.0359836,-0.021986831,-0.05542106,-0.011792721,-0.003397298,-0.012197933,0.08515817,-0.0095496075,0.098804235,0.09394547,0.06850104,-0.06042921,0.039232556,-0.0092085935,0.025449183,0.11434253,0.011083589,0.036317434,0.012129233,-0.038135752,-0.052887257,0.02312908,0.048518173,-0.06123699,-0.059682265,-0.018401342,-0.028175753,-0.013935672,0.04362883,-0.018178642,-0.062515005,-0.027530573,-0.031688176,0.06298716,-0.032593418,-0.049844615,0.0038700174,-0.05874617,0.021809677,-0.104006104,-0.033428065,0.12333256,0.005043368,-0.06266578,-0.055562872,-0.02963888,-0.08483732,0.077000275,0.010923293,0.08795234,0.0358164,0.009320323,-0.106242605,2.542307e-33,0.033416647,0.04494173,-0.06289475,-0.027628848,0.029867567,-0.015534863,-0.039613917,-0.015453051,0.017851707,-0.013806202,-0.036069017,-0.019677155,-0.0016812213,-0.045803733,-0.0060731084,-0.008919413,-0.014896382,-0.04395369,0.02772426,-0.04566573,0.043270838,0.010071169,0.03090256,0.039873984,0.043223493,0.03379854,-0.07063549,0.042353787,0.024534361,0.014980792,-0.009176494,-0.023463786,-0.05185737,-0.007907894,0.030555306,0.012420893,-0.08607241,-0.06959879,-0.017323066,0.1040571,0.00032331466,-0.046690498,0.025760254,-0.009766578,0.046760336,0.0016145485,-0.101747334,0.11715372,0.036753308,0.08780435,0.044630058,-0.02904723,0.09855908,0.053919323,-0.07868188,0.05608753,-0.05838826,-0.014724352,0.02697058,-0.028923273,0.03150512,0.027951924,-0.016937219,0.010597743,-0.072572984,-0.0073514334,0.021171823,-0.059372693,0.016180908,0.094285294,0.0009744853,-0.017179886,0.073770836,-0.006420253,0.121778145,0.01734397,-0.060088467,-0.027512182,-0.0032885917,0.034767732,-0.03999015,0.008551832,-0.006685075,-0.035780754,-0.03302026,-0.027552256,-0.02446128,-0.050037164,0.028156724,0.018945243,-0.013326807,-0.09460867,-0.005621609,0.008132453,0.052305166,-3.2934604e-33,0.07143038,-0.11304863,0.078237906,-0.011812973,0.007861905,0.013775863,-0.0015782525,-0.019037565,0.016649256,-0.02649668,0.0012816084,-0.028916148,-0.08161117,-0.015790142,0.045582622,0.03054515,-0.050921883,0.07914197,0.006029201,0.049894154,-0.052583016,0.023911092,0.050406147,0.0775616,0.012494235,0.0031722873,0.018263238,-0.036893073,0.057554547,0.03784586,-0.066852935,-0.021271538,-0.048192963,-0.03871096,-0.059575148,0.030360319,-0.017283924,0.019147027,-0.008088611,0.025119374,0.05254472,0.0048600165,-0.027602145,0.016897341,0.040649764,0.03552692,-0.03101381,0.028384523,0.04471985,-0.093581244,0.018001998,0.063421026,0.011231767,0.0523252,0.033977862,0.079698086,0.034284353,0.059334904,-0.010466826,-0.026229942,-0.0036435772,-0.1197878,0.0020087091,0.017304983,0.08374659,0.09778006,0.023130931,0.089369774,0.020987768,0.013780823,0.069954254,-0.011755995,0.008050758,0.03274067,0.047082487,-0.03267314,-0.048544995,-0.01715459,-0.004880415,0.021945037,0.012396641,-0.001335727,-0.0021709143,0.011950637,-0.08993607,-0.067988485,0.034723237,0.03315885,-0.016461262,-0.007259767,-0.004393786,0.052199062,0.032059487,-0.028461616,0.06546915,-3.9606782e-08,0.036797553,-0.01819184,0.035825435,-0.043883994,0.115425006,0.030443348,-0.08849466,-0.050708164,0.009505808,-0.01757777,-0.07408716,0.14559579,-0.006188238,-0.04733806,-0.0071974285,-0.014675511,-0.0450736,0.029808845,0.0123628555,0.016716573,-0.09734628,0.04027,-0.1053457,0.02204711,-0.0336079,-0.015518772,-0.01899974,-0.023108806,0.029199937,0.010806126,0.020777434,0.039888352,-0.020942472,-0.027792241,-0.14496663,-0.027892461,0.031567782,-0.12382508,-0.02116486,0.01953499,-0.010518186,-0.033518847,-0.026218304,-0.012567277,-0.046400595,-0.0036050542,0.060429003,-0.057135627,-0.07803489,0.032548983,0.024706647,0.011645287,-0.037114915,-0.02536675,-0.05844047,-0.040308654,-0.010205568,-0.077608965,-0.047266357,-0.0697955,-0.044793986,0.016565403,0.2057914,-0.03831264 +1.5.5.2,"A flavoprotein (FAD). The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor [3]. In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88, L-glutamate gamma-semialdehyde dehydrogenase. Both activities are carried out by the same enzyme in enterobacteria.",384,1.0,-0.12230384,-0.090888284,-0.09994403,-0.042179927,0.06860387,0.02446706,0.011339447,0.10215654,0.020403123,-0.0010415983,0.054395497,0.02284633,-0.06717597,-0.022314437,-0.06005483,0.033975232,-0.075876236,-0.080402076,-0.08505727,-0.006793086,0.0076051187,0.022379968,-0.03346241,-0.062349092,0.042837575,-0.011606436,0.06269013,-0.004363042,-0.039756253,-0.042942528,0.061195124,0.005435276,0.041254282,0.013794471,-0.03325287,0.04928435,0.0024234876,-0.06505697,0.027001822,0.018417098,0.048332155,0.01700301,-0.024646511,-0.05591136,0.057813626,-0.010636874,-0.04623783,0.034672912,0.007374686,0.03591301,0.011094041,-0.021735765,-0.10811014,0.09217273,-0.05819307,0.07107072,0.040113717,-0.06607481,-0.02376067,0.017765768,-0.044165518,-0.0027325707,0.049153414,0.009021038,0.03785207,-0.09526008,-0.025392095,-0.018519988,0.068190165,-0.09355502,-0.04554341,-0.041162036,-0.043276124,0.024609128,0.018623998,0.010124611,-0.05822227,-0.023334948,0.037447236,-0.06801387,0.07521309,-0.023719886,0.06012177,0.044566076,0.059864193,-0.042296134,0.0013087406,0.014568164,-0.0013481954,0.059586897,0.0010001766,0.021173004,0.011636448,0.02254802,-0.106669925,0.071339615,0.002857203,-0.05994268,-0.048644062,-0.017654605,-0.04456361,0.034394767,0.032590296,-0.03435184,-0.055674996,-0.023686953,0.028387485,0.11157092,-0.041706756,-0.04383745,0.06190168,-0.03763918,0.036191806,-0.021986803,0.044345234,0.026035218,-0.008341011,-0.055165403,0.012795228,-0.025454037,-0.039680745,0.051228143,0.05744332,0.0572573,0.0031335042,0.04997254,-0.03772795,2.887878e-33,0.08002211,-0.03398669,-0.01778182,-0.053055603,0.008055115,0.007926329,-0.12674871,0.001522314,0.06705707,-0.062224995,-0.07801217,-0.05550927,0.04175383,-0.032675575,0.03008431,-0.00968659,-0.066395365,-0.021781929,0.07731785,-0.029591992,0.025166407,0.051315665,0.026939146,0.021397324,0.08264566,0.0004658506,-0.038682263,0.027141651,-0.01746414,0.020927897,0.029868593,-0.121075764,-0.067169875,0.044763017,-0.046904698,0.057486158,-0.042763267,-0.09644151,-0.065397955,0.039063934,0.005265165,0.0033741745,-0.018066192,0.017404253,0.018589232,-0.0738734,-0.06547457,0.1282092,-0.00129505,0.10430038,0.01484605,-0.0553056,0.11530364,0.0038817765,-0.07828684,0.057710506,-0.028242992,0.011471264,0.0980374,0.029797854,0.034296308,0.10066027,-0.04417739,0.09230563,0.0007637117,0.021045625,-0.034378804,-0.080053315,0.014138644,0.081359364,-0.06249345,-0.031953126,0.12085276,-0.03211778,0.001489863,-0.024560636,-0.10009758,-0.042685978,0.008963827,0.020020075,-0.009290433,0.019179152,-0.030650146,0.008356069,-0.022271603,0.016970778,-0.02387006,-0.07721273,0.028450677,0.004517025,0.07991305,-0.02002314,-0.004724677,0.0074227834,0.054432005,-2.7921999e-33,0.0674688,-0.072298564,0.027843352,0.011314487,0.0116548855,0.058911864,0.0033329106,-0.02506621,0.051313072,0.014477851,0.00825522,0.0027388667,0.00070991827,-0.031216137,0.09674966,-0.0128812995,-0.060937338,0.05517525,0.03504058,-0.035079885,0.0209763,-0.0066980445,0.08973608,0.06752872,0.04578958,-0.034443934,0.021405483,-0.023943545,0.018177997,0.0056006443,-0.0046994095,0.06547611,-0.05293706,-0.053996455,-0.04581473,0.03414002,-0.010140694,0.06436372,0.025676675,0.019620376,-0.013932463,0.04532324,0.02783277,0.02052419,0.008123557,0.07011612,-0.05948506,0.0012597605,0.038349263,-0.032618273,0.015676482,0.03184759,-0.03999178,-7.4353266e-05,0.05060347,0.08452713,0.025175229,0.023974301,-0.032095905,-0.023728048,-0.031361315,-0.14554048,0.009385945,-0.023185633,0.061495543,0.053381585,0.059608996,0.07294732,0.041525576,-0.011720928,0.12286994,-0.0117205735,-0.020010997,0.036600523,-0.00046992954,-0.041689947,-0.002230108,0.03300385,0.017636742,0.009821563,0.057306528,-0.04140415,0.0076419534,-0.02266453,-0.06474337,-0.13507463,-0.03859767,0.11262983,0.03577241,0.0342471,-0.041059993,0.047899947,0.0023035828,-0.02653427,0.07220402,-4.204983e-08,-0.00014601155,-0.025987877,0.07901136,0.033055358,0.105968244,0.03541006,-0.017310757,-0.033855993,0.068266,-0.054873895,-0.04668591,0.12988721,-0.047449686,-0.026537236,0.041287955,0.036676966,-0.019324057,0.009922025,-0.046309564,0.0016343517,-0.061507363,-0.020360148,-0.11927714,0.044727586,-0.03504823,-0.052830063,0.017587878,0.02207581,0.015170592,-0.013860955,-0.031376716,0.056106724,0.044433635,-0.060854483,-0.09465514,-0.03816346,0.09031295,-0.026584072,-0.046676315,0.05508896,-0.060355067,-0.024392655,-0.03684592,-0.05807171,-0.009094287,0.0044988566,0.021220297,0.008760705,-0.070721395,-0.013381502,0.005275995,-0.040852644,0.009075818,-0.019606547,-0.10532079,0.024732646,-0.027584918,-0.095218614,-0.013120763,-0.050518535,0.036107223,0.05865167,0.15779929,-0.015204292 +1.6.3.2,"A flavoprotein (FAD). NADPH is a better substrate than NADH [1,3]. By removal of oxygen the enzyme is involved in aerobic tolerance in the thermophilic anaerobic archaeon Thermococcus profundus and in Giardia intestinalis, a microaerophilic single-celled parasite of the order Diplomonadida. ",384,0.99999994,-0.07130316,-0.020577094,-0.09339301,-0.013811929,0.0869909,0.009595241,-0.038578495,0.096895635,0.0760886,-0.013990705,-0.018491458,-0.0137518635,-0.0537938,0.074784435,-0.10160843,0.0024529514,-0.017555607,-0.030698223,-0.03256691,-0.025268702,0.030279305,0.026620112,0.05870762,-0.03980172,0.0428606,-0.024717467,-0.009685205,0.0010998283,-0.021557776,0.008854643,-0.010319783,0.08488254,0.08227717,-0.033699717,-0.024545826,0.07820504,0.06173615,0.005057962,-0.030813668,0.045904294,0.024488369,0.014663252,0.003992185,-0.009708703,0.021512773,-0.0030311518,-0.068572134,0.084815346,0.03937137,0.0071465163,-0.057048816,-0.032071363,-0.0877921,0.08263289,0.039418604,0.039081562,0.011200091,-0.06483006,-0.06305902,-0.07117993,-0.0035734375,-0.05305541,0.025445255,0.024275523,0.041727945,-0.108731,0.013167684,-0.035407223,-0.0045644804,-0.024853468,-0.085136764,-0.010803564,-0.019359477,0.022415847,0.019095076,0.082396455,-0.056816194,-0.11128934,0.06536917,0.05234377,0.07381854,-0.039613582,0.026261378,0.045253508,0.06703344,-0.017253213,0.030567566,-0.016488872,-0.010497305,0.037332308,-0.025674688,0.017181713,0.026228298,-0.0029830257,-0.13411063,0.034333155,0.07069353,-0.05523799,-0.07873257,-0.019230135,-0.01768092,-0.011537273,0.027432656,-0.031822674,-0.05725806,-0.051954735,0.0022517205,0.075429596,0.0013864948,-0.033801403,-0.0034916915,-0.032564525,0.03778988,-0.060999162,-0.02281669,0.07795246,-0.034292907,-0.052009456,-0.058000952,0.016387558,-0.09145866,0.0751643,0.03222854,0.07505204,0.0413638,0.003344804,-0.069353074,4.6693152e-33,0.10077174,0.01672872,-0.05325147,-0.03562572,0.024016902,-0.0026384147,-0.054261863,0.0010220588,0.055955734,-0.07232564,-0.027161654,-0.027622497,0.039833605,0.004006841,0.057672653,0.042153865,-0.039174028,-0.02897299,0.004720469,-0.02174008,0.057140324,0.040252775,0.003974566,0.035244126,0.0985328,-0.029321989,-0.069120385,0.049119063,-0.019979654,0.030780245,0.032099303,-0.111928545,-0.10582507,0.021353127,0.0029012528,0.06240776,-0.08381592,-0.10453769,-0.110022046,0.011252567,-0.051591884,0.017189622,0.019707356,-0.006359169,0.05159913,-0.09420886,-0.06532353,0.10036553,-0.007989842,0.09271893,0.059254803,-0.03639892,0.117973685,0.035141964,-0.060136825,0.035233352,-0.03943677,-0.009431767,0.0148862135,0.028011167,0.01673221,0.044572674,-0.04313248,0.14406694,-0.06729424,0.013278839,-0.07577412,-0.054011427,0.020804746,0.13685052,0.009464744,-0.030013459,0.0051639993,0.05246739,0.0064244876,-0.06921421,0.014465587,-0.06373655,-0.011490959,-0.014910905,0.024237318,-0.03293087,-0.043545604,-0.054499075,-0.10234977,0.052939724,0.04859721,0.004077412,0.0444946,0.033698145,0.051517982,-0.0431491,0.025102874,-0.02115453,0.030742574,-4.003371e-33,0.09732698,-0.09819073,0.02087183,-0.044816595,-0.013045273,0.087145016,0.048737224,-0.039585877,-0.002613074,-0.13202609,-0.009205397,0.0025299108,0.0074538095,0.0071656764,0.0796614,0.012808845,-0.01765535,-0.0011376543,0.062847085,0.02214179,-0.066380836,0.050284453,0.040887784,-0.010914753,-0.00023502873,-0.046733472,-0.017007094,0.004757567,-0.022673681,0.013339701,-0.031338084,0.05214969,-0.09711509,-0.03349109,-0.00016400983,0.06555337,-0.011421503,-0.02997892,0.007923038,0.052356504,-0.0022757372,-0.0009532667,-0.063619055,0.07623707,0.05609373,0.04429841,-0.06208507,-0.007643503,0.09770963,-0.04034175,0.019245213,0.00299056,-0.014422799,0.032191046,0.0747511,0.006857634,0.0026011998,0.03968703,-0.00027424106,-0.01320009,0.025043156,-0.06769751,0.004755167,0.021097323,0.089694284,0.08998533,0.0037523934,0.105815664,-0.013544454,0.011889258,0.10135088,0.01920886,0.032791775,0.053209852,0.009090594,-0.06702086,-0.03959593,0.118204996,0.01935502,0.025338685,-0.009901226,0.03803043,-0.0046012797,0.0154982,-0.06417446,-0.08700545,0.0040814676,0.010983768,-0.03943671,0.021873076,-0.0138439275,-0.007717054,-0.002235155,-0.024768353,0.058597174,-4.067166e-08,0.08783241,-0.047323506,0.034056973,-0.015023498,0.033677112,0.010747846,-0.0014911128,-0.076490715,0.037998915,-0.003919727,-0.0124907885,0.15348618,0.045312185,0.009873038,0.06277865,-0.014228877,-0.06620717,0.002324656,-0.04434036,-0.0012824807,-0.09874337,0.02255255,-0.12570588,0.02359645,-0.025490388,0.0059330408,0.02395051,-0.025823826,0.05159612,-0.04216278,-0.027450675,0.0317467,0.023744967,-0.058253694,-0.11999284,0.014901589,0.010005317,-0.014643101,-0.030806331,0.031267177,-0.01889871,-0.027216049,-0.0085047,-0.04007032,0.015547287,-0.0077807033,0.059000168,-0.027066972,-0.047224738,-0.009693589,-0.0010746021,-0.014661118,0.029407863,0.01757739,-0.0747756,-0.05713678,-0.00013976845,-0.075266756,-0.05600978,-0.066102065,0.017782925,0.046529837,0.122678354,-0.011851717 +1.6.3.3,"A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O2-forming enzyme and a H2O-forming enzyme (cf. EC 1.6.3.4, NADH oxidase (H2O-forming)) [1]. The enzymes from the anaerobic archaea Methanocaldococcus jannaschii [6] and Pyrococcus furiosus [3] also produce low amounts of H2O. Unlike EC 1.6.3.1 (NAD(P)H oxidase) it has no activity towards NADPH. ",384,1.0,-0.04048267,-0.063096374,-0.11331294,0.0018393714,0.13264725,0.032866266,-0.09346108,0.069458105,0.05752596,-0.0058533032,-0.01294637,-0.0076478235,-0.060019456,0.017974075,-0.07382159,0.0360327,-0.0593069,-0.027499706,0.041500192,0.030744787,0.09546613,0.02914441,0.026010238,-0.00905386,0.018940048,0.012811128,0.006268501,-0.018836522,-0.032041796,-0.004202672,-0.02108176,0.00085271156,0.06370771,-0.058431853,0.005004971,0.06833626,0.041072924,-0.011977856,0.027120013,0.015203531,0.0061874813,0.011557141,-0.00801256,0.017413558,0.0402269,0.023129813,0.07997052,0.082779825,0.0055441544,-0.002882631,-0.053572617,-0.017116964,-0.11809833,0.001929695,0.021323612,0.022175612,-0.013661922,-0.03419852,0.0099023245,-0.070990644,0.007624351,-0.05765219,0.095157534,-0.0022817713,0.027527304,-0.09683182,0.019144127,-0.03624819,0.02097678,-0.073215276,-0.08723181,0.04177573,0.008345932,0.030427992,-0.018233603,0.10744224,-0.054913893,-0.04798105,0.037075143,-0.0043858667,0.060786664,-0.02500841,-0.007169574,0.08106316,0.07748911,-0.0014365977,0.00845705,-0.0204338,-0.010584009,0.004678329,-0.010899021,-0.007676726,0.004202707,-0.017899338,-0.14358717,0.014026495,0.055055283,0.024125854,-0.057639237,-0.044244654,-0.056918737,0.03894323,0.048085567,-0.039248448,-0.009736216,-0.009046317,-0.049874112,0.089416005,0.02008717,0.022188494,-0.0053227013,0.010751559,-0.044903632,-0.058205444,0.021016786,0.03967933,0.009725044,-0.064988054,-0.15218323,0.031139286,-0.033828616,0.052479293,0.06345215,0.022260766,-0.01510853,-0.03609069,-0.10926849,4.3243175e-33,0.078935556,0.02362634,-0.006685236,-0.030146483,0.040274307,-0.016397484,-0.1133975,0.028802572,0.06400672,-0.023235328,-0.06703908,-0.04663552,0.07486199,-0.016013157,0.044100434,0.0070883087,-0.011753134,-0.04692123,0.029165685,-0.026849775,0.0064375913,0.04568842,0.010325687,0.028052406,0.06712034,-0.016763082,-0.024854869,-0.0063537154,-0.0007992686,0.0025467498,0.043163154,-0.12765619,-0.10170126,-0.040812764,0.07117838,0.019643016,-0.10486837,-0.06606329,-0.05116663,0.012579644,-0.08194226,0.02390304,-0.026828764,-0.041015577,0.04796183,-0.10444639,-0.028220836,0.097679675,0.05178275,0.09861741,-0.0018945024,-0.0694142,0.10291857,0.03604236,-0.066484965,-0.025869789,-0.006141524,-0.018662365,0.054819975,0.074491866,0.010399793,0.045659106,-0.059570767,0.054468647,-0.09228908,0.00920654,-0.07062717,-0.017608423,0.056823898,0.11460895,0.05938947,0.01601228,0.032418188,0.011095688,0.0060992967,-0.0350762,-0.0043716645,-0.020924274,0.06625207,0.025253395,0.042470127,-0.013574579,0.0036104561,-0.038259637,-0.05617979,0.095355056,-0.015018913,-0.0007183665,-0.010278293,0.061938237,0.03644562,-0.043745674,0.0019095236,-0.079936534,0.025689485,-3.5056606e-33,0.059916615,-0.077602886,0.030483572,-0.074132755,-0.0017470584,0.10810542,0.0060926843,-0.056360252,-0.025400175,-0.1275841,0.045459066,-0.0072197854,-0.010266727,-0.013937487,0.0843319,-0.048485614,-0.02444514,0.07518238,0.0607534,0.015716529,0.047107197,0.03191083,0.020002866,-0.037110645,0.06293078,-0.035850815,-0.04662635,0.036765452,0.02806594,0.035173822,-0.0071214214,0.03625662,-0.065244146,0.0010492707,-0.026644327,0.005809099,-0.07227716,0.037201777,0.03632512,0.04626611,0.04666184,-0.0010255367,-0.00075191434,0.04260122,0.044748627,0.07407333,-0.08050748,0.040464673,0.08854314,-0.042988673,0.06596227,-0.0077493456,-0.067783445,0.009457674,0.08006327,0.049454395,-0.038551036,0.06089781,0.0015307181,-0.003129376,-0.015079051,-0.08350497,-0.02006529,0.011433937,0.077080846,0.053724788,0.04067489,0.09753972,0.0056044124,-0.015332347,0.08289033,0.018156052,0.01746988,-0.010281958,0.0030673835,-0.046054862,-0.063624285,0.057389773,0.006841676,0.0039981464,0.02188552,0.006038466,0.010093035,-0.013128951,-0.032385465,-0.04328746,0.023998618,-0.008751341,-0.0075394744,0.04917004,-0.031076936,0.058577787,0.007889877,-0.031640355,0.022452017,-4.301651e-08,0.008341609,-0.03130732,0.12096315,0.002561965,0.050687615,0.02173811,0.032043014,-0.03438476,0.03284005,0.006071012,0.038376946,0.08570961,0.011116096,-0.07407537,0.027876437,-0.029087739,-0.06059089,0.03339495,-0.02312726,-0.007198764,-0.06376307,0.002590755,-0.14087577,0.07495241,0.024682626,-0.05456654,0.02421303,-0.06680081,0.025240682,-0.048993215,0.05211105,-0.0047064745,0.052531302,-0.059617005,-0.102230705,-0.043749347,-0.04164958,0.008874877,-0.07150092,0.015442142,-0.017682713,-0.018326143,-0.01623114,0.00048991526,0.026952237,0.024777249,0.019509712,-0.011311907,-0.07618926,-0.081866026,0.07041574,0.009037019,0.025411664,-0.02973299,-0.14081933,0.010543616,0.033736445,-0.085537985,-0.05323997,-0.08513149,0.053419918,0.008843264,0.1324976,0.04601077 +1.6.3.4,"A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O-forming enzyme and a H2O2-forming enzyme (cf. EC 1.6.3.3, NADH oxidase (H2O2-forming)) [1].",384,1.0,-0.07793207,-0.08681385,-0.118389234,0.0073175593,0.124618776,0.02495516,-0.068683006,0.09168198,0.06264859,-0.032947883,0.017526597,-0.008374754,-0.05625,0.0182425,-0.091605976,0.022539968,-0.08559998,-0.021652628,0.056040004,0.004341833,0.057318006,0.053283338,0.033007592,-0.014694104,0.020202525,0.04177409,0.013391447,-0.03205838,-0.016854264,-0.0019682974,0.026475918,0.008640221,0.058287244,-0.043459263,-0.02284596,0.038308296,0.06851379,-0.009442317,0.03840306,0.037009787,-0.013861121,0.0047455444,-0.0011448854,0.021025257,0.059638713,0.04162544,0.0750795,0.10476887,0.0029257345,-0.00031953512,-0.010434846,-0.03581468,-0.13525836,0.03233361,0.048236523,0.010234936,-0.015963938,-0.054689668,0.016489312,-0.036266882,0.014668884,-0.04742413,0.087318935,-0.0029740883,0.042264268,-0.06851836,-0.007096245,-0.036393806,0.017898142,-0.06497267,-0.061744273,0.02650202,0.00201722,0.044920504,-0.023107957,0.10078994,-0.064980894,-0.052842837,0.024453172,0.0092401225,0.081360176,-0.024494447,0.034510337,0.07860949,0.084245086,-0.015030755,0.028034616,-0.023849344,-0.03230023,0.005415947,-0.016313998,-0.017595122,-0.020637833,-0.009738298,-0.13193703,0.027895484,0.029559508,0.014683011,-0.051816452,-0.018959288,-0.07875937,0.021565948,0.08554634,-0.028044697,-0.029624563,-0.03979472,-0.04512693,0.07403699,0.01662203,-0.016562086,-0.014391225,0.035046466,-0.061477583,-0.058604844,0.035343174,-0.0030606624,0.0006678101,-0.05374489,-0.09547545,0.010305393,-0.025746219,0.07495537,0.05088418,0.038317565,0.0027159543,-0.046771623,-0.11067714,1.687293e-33,0.0645903,0.005740683,-4.324455e-05,-0.022175806,0.035447706,-0.006397401,-0.10869847,0.032384954,0.044588782,-0.038926817,-0.05882024,-0.06397328,0.041056015,-0.0030771317,0.05088589,0.004883821,-0.027024271,-0.056995228,0.07078786,-0.08781543,-0.0013953835,0.078974694,0.013888155,0.034053694,0.076868676,-0.02120536,-0.03430421,0.007946066,0.026312746,0.0067766393,0.016099542,-0.100814566,-0.10584662,-0.02739217,0.019788308,0.020989891,-0.08933509,-0.08702204,-0.031979967,-0.00020161469,-0.040848836,-0.0065035983,-0.021428816,0.0036271194,0.030364169,-0.08794714,-0.052847758,0.084053814,0.046929136,0.11325917,0.012155924,-0.05472031,0.09588615,0.033310443,-0.07164235,-0.024394743,-0.0349701,0.0053536263,0.035094164,0.058019638,0.016937435,0.059231177,-0.063778386,0.05216915,-0.094390176,0.0079169525,-0.08460681,-0.037468266,0.07080558,0.11351578,0.052339956,0.007442364,0.05274286,0.010167521,0.0152778365,-0.05006549,-0.01699582,-0.010359175,0.047912717,0.020735383,0.003447898,-0.0024089634,-0.030715767,-0.04856847,-0.07367345,0.08786776,-0.027837284,-0.035660844,-0.014964394,0.039754376,0.020745726,-0.047148462,0.01122814,-0.063622095,0.022939112,-8.687837e-34,0.04052329,-0.1063497,0.061083484,-0.03894988,0.018416002,0.081825845,0.019911774,-0.03625075,-0.033502348,-0.096191876,0.047949184,-0.03739615,-0.028228143,-0.012159895,0.080543116,-0.014743154,-0.04230167,0.055929486,0.051236875,-0.002024259,0.040215842,0.036725346,0.059359964,-0.010529359,0.043962806,0.0058012884,-0.024499316,-0.0043649115,0.03859219,0.048966404,-0.03859669,0.028805897,-0.057549585,0.027533084,-0.067317255,-0.012660725,-0.035566643,0.03465438,0.018700615,0.029131392,0.018161222,0.0209261,0.0077508846,0.085761905,0.051531017,0.07614235,-0.036735363,0.049739376,0.09294805,-0.06416909,0.03736752,0.020737339,-0.0602442,0.016725956,0.06847447,0.030078238,-0.020874765,0.04410618,-0.0043460215,-0.0076508094,0.0050778356,-0.10260699,-0.01747162,0.0041378997,0.12190402,0.027081741,0.05025424,0.099645905,0.013177456,-0.015917433,0.09461786,0.003065879,0.0051635653,-0.009953828,0.027250156,-0.061425526,-0.06952659,0.07855806,-0.0014381916,0.031714045,0.02675699,-0.016462198,-0.0059928456,0.04319932,-0.060498983,-0.06505705,0.034432203,0.026562702,0.018919999,0.0443479,-0.03043234,0.09267087,0.021399204,-0.012761173,0.060809422,-3.5065497e-08,0.0021224734,-0.05834673,0.09222196,-0.016333822,0.088082306,0.023807263,-0.028638074,-0.023500301,0.019626332,-0.009030617,0.008379513,0.105807245,-0.012200807,-0.044071108,0.017931748,-0.050172072,-0.063845135,0.02559625,-0.007082018,0.005991779,-0.07979937,0.039525833,-0.11621321,0.060557038,-0.0094546415,-0.041977253,0.01152017,-0.04785603,0.030718623,0.014982633,0.05104826,0.0025759,0.03582397,-0.08824041,-0.11906761,-0.04827838,0.0046867416,-0.012870473,-0.06161697,0.026973581,-0.019445868,-0.013418287,-0.008337772,-0.0003263801,0.026732888,0.010331764,0.029678097,-0.002229626,-0.08393392,-0.074437976,0.05917651,-0.0016403159,0.019356297,0.011005335,-0.13543741,-0.01816798,0.0039937696,-0.09024703,-0.04087967,-0.08675455,0.03146593,0.035583947,0.15454915,0.06589662 +1.8.1.19,A iron-sulfur flavoprotein. In the archaeon Pyrococcus furiosus the enzyme is involved in the oxidation of NADPH which is produced in peptide degradation. The enzyme also catalyses the reduction of sulfur with lower activity. ,384,1.0,-0.025164964,0.009941101,-0.09124379,0.049287487,0.103685796,0.047666036,-0.026959885,0.028565358,0.057267178,-0.03086267,-0.011524266,0.04483094,-0.10784866,0.008439084,-0.07819415,0.03036923,-0.106131606,0.03690553,-0.0014563272,0.001267094,0.064707585,0.005685471,0.024378562,-0.006064751,-0.02461995,0.037300613,0.027194655,-0.015049765,-0.039108355,-0.0075268266,-0.020954361,-0.016219484,0.041023184,-0.04374402,-0.02447645,0.07945437,-0.01340839,-0.04363416,0.013473108,-0.017973596,0.032746926,0.011829926,-0.04502388,-0.039490473,-0.023171853,0.028758582,0.03835026,0.07345124,0.0043043597,0.00012287358,-0.073647976,-0.0045626736,-0.095193915,0.04905343,-0.028857067,0.016598478,-0.0037287958,-0.09936899,-0.02011428,-0.09161496,0.040585853,-0.016283778,-0.023303555,0.01992909,0.023265203,-0.08380949,0.07172533,-0.037097033,0.012122829,-0.07428417,-0.054044716,0.014049797,-0.07531484,0.034766745,0.004036625,0.12772681,-0.03196935,-0.07886936,0.051287357,-0.020498488,0.080960125,-0.009266165,-0.014994181,0.09910494,0.07161474,-0.008182805,0.010929452,-0.035442516,-0.016802864,0.0042001694,0.026542433,-0.03844345,0.019778434,-0.010917284,-0.09145797,0.0241137,0.057874836,0.08192449,-0.03239222,0.030921942,-0.056020565,-0.0034309498,-0.018382479,-0.08373967,-0.059854977,-0.012796491,-0.04876563,0.13201495,0.066323094,0.016625859,-0.039458327,-0.06165596,-0.0349765,-0.020263681,0.028888851,0.11172355,0.09361787,-0.030694105,-0.12308403,0.051894236,0.014365809,0.0704321,0.023270447,0.05889892,-0.026514597,-0.002237879,-0.15189667,1.2389411e-33,0.083108865,0.042256624,0.03119581,-0.05256904,0.029872151,-0.012478545,-0.07842776,-0.03364138,0.026940947,0.010345675,-0.0813542,-0.003802103,0.05463846,-0.055989597,0.0014881947,-0.0059656827,-0.007988411,0.010038989,0.076091565,-0.036685698,0.029137244,0.08334684,0.01497229,-0.0045943093,0.028149297,0.040802814,-0.015681729,-0.0074652187,-0.089847274,0.008547745,0.07324845,-0.11069905,-0.13068259,-0.013465851,0.1161618,-0.05670301,-0.008211742,-0.11272311,-0.05948384,-0.009042164,-0.070861906,-0.054443646,-0.017786609,-0.016956644,0.032001495,-0.09930449,-0.06604488,0.11151059,-0.0063172784,0.065105096,0.011449265,-0.021130655,0.12570654,0.063250236,-0.09385995,-0.011912051,0.019768158,-0.08296076,0.015084498,0.03308706,0.077434085,0.041767254,-0.004471753,0.043318454,-0.044061024,-0.026295915,-0.045876518,0.038650922,0.046390507,0.08963624,-0.020943472,0.034569427,0.009770489,0.015759021,-0.024182692,-0.0022988643,-0.0685753,-0.0075226594,-0.004098844,0.01117753,-0.07277608,-0.04507868,-0.024828086,0.033934757,-0.077801965,0.0681277,0.022504266,-0.025572693,0.008864151,0.0013013746,-0.0047958256,-0.028650537,-0.056300804,-0.02267346,0.010274336,-2.2068477e-33,0.04256335,-0.083693705,-0.02607147,-0.06480771,-0.061135713,0.021609718,0.04356235,-0.010162935,-0.042048827,-0.060064275,0.029886786,-0.035955183,0.03284454,-0.045494575,0.10105137,0.021355424,-0.00019790884,0.030084765,0.060539197,0.0076544844,0.005236943,0.045234885,-0.022016354,0.006649459,0.03184574,-0.06253409,0.024620172,0.01972459,0.05959332,0.04114211,-0.014793113,0.021593029,-0.006877984,-0.08179821,-0.014445465,0.01951076,-0.011246068,0.0025518422,0.055355612,0.009949539,0.071690395,-0.013892515,0.027117798,0.07650774,0.08155715,0.05352037,-0.073121585,0.039258298,0.0707997,-0.024954686,0.11649212,0.010230655,0.018045412,0.06414142,0.07387342,0.026181797,-0.024096198,0.041972537,-0.04419631,0.06748121,-0.035576142,-0.08052984,0.02639217,0.008354213,0.056259297,0.040507313,-0.019398665,0.020077579,0.0045600757,-0.015977519,0.09529757,0.043687053,0.015356204,0.018362217,0.002732338,-0.0482178,-0.010891529,0.061983377,0.018289376,0.01179231,-0.018950557,-0.02125783,0.009106025,-0.070881665,0.004722412,-0.12310036,0.022079807,0.096370354,-0.014006015,-0.0359732,-0.0058056843,-0.011844568,-0.029314129,-0.01956441,-0.032689523,-3.070603e-08,-0.005247746,0.016822461,0.044050574,0.023257444,0.027648857,0.00067894836,0.07407076,-0.037566226,-0.027669143,-0.020431813,0.028798591,0.12371263,0.05105043,-0.020742664,0.06634871,0.023202198,-0.04877805,0.044260062,-0.010786159,-0.042432662,-0.057235826,-0.025676029,-0.092562966,0.047456264,0.028929401,-0.0518284,0.038468473,-0.07240997,0.01917764,-0.048004016,0.0312696,0.021985935,0.037651177,-0.048233654,-0.042832706,0.038537066,-0.07955401,-0.03563281,-0.0074792956,0.003309894,-0.08601523,0.029435897,-0.052265868,0.00023149193,0.01634847,0.01690849,0.0005958926,0.022726387,-0.06929201,0.01813318,0.058747068,0.039132543,0.025002843,-0.04897899,-0.106147006,0.012105422,0.10440175,-0.077925086,-0.04032774,-0.044539593,0.07740206,-0.031043684,0.12373026,-0.002085747 +1.13.11.76,"The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent). The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.74, 2-aminophenol 1,6-dioxygenase.",384,1.0,-0.09338513,-0.033501454,-0.06857293,0.026436655,0.07619914,-0.003630452,-0.05118899,0.025369449,0.020897005,-0.08790525,-0.024262223,-0.095840506,-0.05250839,0.019872041,-0.036986675,0.0048917406,-0.028661199,-0.038094483,-0.0027034485,0.024076447,-0.039106704,0.061468326,-0.007362642,0.004711467,-0.028469624,0.016734693,0.08327046,0.03786816,-0.050661825,-0.027435035,0.033097383,-0.039289318,0.0502084,-0.0037971141,0.029002529,0.052691966,-0.0040023034,-0.06460839,0.066616125,0.03431644,0.0072931233,0.07958438,-0.011699829,-0.05707815,-0.028428659,-0.06534476,0.021879103,-0.00056591653,0.028390342,0.019365093,-0.025699748,-0.040143885,-0.02732528,0.08321819,0.06304498,0.052911505,0.026250657,-0.02376785,-0.09029669,0.00941571,0.025403261,-0.030463226,0.046472568,0.018398993,-0.032276466,-0.008964183,0.014810679,-0.062689595,-0.024176223,-0.13417955,-0.07863422,-0.064006455,-0.048940632,0.010679767,-0.046254132,0.030298045,0.028758341,-0.015669832,0.0967287,-0.0868487,-0.054158714,-0.033086915,0.049623262,0.10195381,0.049811732,-0.0006675786,0.020107731,-0.03880201,0.028545782,0.07361192,0.0090543255,0.0067605493,0.0011916696,-0.057592466,0.0070778485,-0.005697816,0.05903675,0.0859067,-0.0025163353,0.018663207,-0.0037976522,0.05109885,-0.048541483,-0.073283404,-0.047919586,-0.011569568,0.025653534,0.07508408,0.03613115,-0.040431257,0.046690237,0.0007468381,0.07568952,-0.010323254,-0.02220091,0.035084717,0.09309054,-0.01837216,-0.04420374,0.01908809,0.07988958,-0.054031998,0.06333629,0.022550019,-0.06699355,0.024299668,-0.089624636,1.0465795e-33,0.042563595,0.0008461093,-0.017865257,-0.0027230117,0.006039935,0.047916606,-0.111785516,0.021503827,-0.09791567,-0.03495994,-0.0565271,0.002963492,0.04299831,-0.028585432,-0.001711122,-0.037112698,-0.04476297,-0.015184859,0.074949495,0.009080312,0.050273936,0.056272622,1.8566041e-05,-0.010686691,0.015846562,0.061671466,-0.020255089,0.02406393,-0.016079407,0.017263547,0.013166247,-0.08152014,-0.1082965,-0.05280007,0.049809203,-0.0143098775,-0.004098687,0.0034517525,-0.048745207,0.037150122,0.01928533,0.040463503,-0.015517257,-0.07721862,0.041153077,-0.10521223,-0.007975733,0.11137652,0.029678568,0.052100297,-0.030894252,-0.01934008,0.10003106,-0.0928707,-0.044846237,-0.0035688381,0.003117735,0.05237177,0.12565328,0.0958196,0.050848916,0.049193863,-0.053230282,0.103961065,0.029629653,0.01968526,-0.053876907,0.00037435425,0.061058115,0.09529603,-0.022687197,0.037935942,0.05953406,0.02220975,0.011836928,-0.078229606,-0.09015693,-0.025583304,0.06589367,0.028209997,0.013180129,-0.056459054,0.038093884,-0.037273705,-0.070226185,0.04526093,-0.054443672,0.022352826,-0.019262517,-0.017168894,0.0691923,-0.041013844,-0.07448247,-0.062222123,0.079988085,-1.8968102e-33,0.02391188,-0.036507048,-0.02634985,-0.10448966,-0.026379736,0.052682906,0.032814804,-0.04718927,-0.011322105,0.03941176,0.09028299,-0.018812316,0.009640361,-0.06798721,0.027466081,0.04848346,-0.09352348,0.005786274,-0.010487223,-0.008377294,0.08824407,-0.0022579748,-0.01732293,-0.03099491,-0.0035389948,0.035074275,-0.11922987,0.08509223,0.04328919,0.054880712,-0.07703529,0.082138516,0.0033219766,-0.086346276,0.023069175,0.03965016,-0.07936133,-0.005688036,0.02629272,0.00041511157,-0.022709174,0.028107993,0.049719285,0.1127018,0.0025568644,0.10005719,-0.11509741,0.0034862102,0.014807055,-0.008771004,-0.052628107,-0.018175606,-0.057288647,0.051581714,0.0133462325,-0.02102212,-0.037225503,0.04393582,-0.06169145,0.029033562,-0.021978924,-0.059766736,0.044407904,0.022066655,0.026984068,0.029561153,-0.066561684,0.04837297,0.039583452,-0.0022556577,0.07439206,-0.04827617,0.050592147,-0.049096048,-0.0379636,-0.024989866,-0.009309436,0.05333117,0.0074748807,0.028431505,0.028647983,-0.034832727,-0.017131416,-0.03578344,0.0031754621,-0.10195191,0.012154953,0.049778845,-0.048212007,0.022264244,-0.04590797,-0.016634597,-0.047583777,0.011029804,0.027550856,-4.4047894e-08,-0.04028693,-0.12901819,0.0908391,0.003326828,0.039785314,-0.007105978,0.028858157,-0.026005145,0.0344995,-0.005839234,0.034632415,0.06632348,0.042434372,-0.018888962,0.05953018,0.07458753,-0.03346468,0.012789686,-0.00053158775,0.008628534,-0.0011086644,-0.013264849,-0.029068787,0.003614434,0.002230266,-0.06714928,-0.06109822,-0.03700149,0.0060032196,-0.035896897,-0.045787908,0.05840606,-0.0049087885,-0.0295138,-0.09814765,0.033700943,-0.06933377,0.028674375,-0.097862504,0.037675418,0.0027261348,-0.06379009,-0.10231114,0.003871919,0.04826876,0.03805502,-0.022613239,0.03747544,-0.021265732,-0.03295551,0.056313735,-0.0293651,0.05132099,0.031259436,-0.113988064,0.12292446,0.008516913,-0.04968373,-0.008935389,-0.0007302229,0.018795397,0.05412654,0.17910561,-0.06802308 +1.13.12.21,The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.,384,1.0,-0.036142554,0.038560607,-0.19773322,0.0069456864,0.017356152,0.010842825,-0.069723584,0.0420456,0.059147898,-0.028586168,-0.031467214,-0.045581423,0.027476395,0.026639782,-0.078159526,-0.0258469,-0.08937887,-0.0034617274,0.037141588,-0.100089505,0.031091098,0.06926602,0.051215608,-0.013623889,0.032998163,-0.017198823,-0.031999037,0.011326188,-0.04699763,-0.0012453045,0.03483651,-0.031647053,0.029722866,-0.079163454,0.059606254,0.08502329,-0.103333525,0.010912326,0.14426933,0.034539163,-0.039079875,0.018001094,-0.036917437,0.058555264,-0.08650144,0.0943246,0.040439393,0.044735294,0.0031133676,0.020129804,-0.033301465,-0.013897964,-0.12506393,0.04701788,0.03153882,-0.009836116,-0.018496877,0.0002331535,0.03401711,-0.011996553,0.10920336,-0.039951693,0.025532516,0.047519695,-0.1015266,-0.046078686,0.010141738,-0.046629712,0.035436396,-0.033074725,-0.0765225,-0.006110262,-0.03026444,0.022762038,-0.022619097,0.039559465,-0.0013000163,0.006902308,-0.03399075,0.03255284,0.062243596,-0.055550743,-0.023484156,0.12265568,0.06341723,-0.017261421,0.022513468,0.055532217,0.06979526,0.05584771,0.0651288,-0.0065636383,-0.029514309,-0.026581075,-0.06977601,-0.03257691,-0.0010235353,0.018508209,-0.026235601,-0.04614502,-0.0757077,-0.005500501,0.021737339,0.0062319087,-0.02789335,-0.013706737,-0.031351876,0.09682425,0.03775092,-0.046317246,-0.04850965,0.05989171,-0.0035141513,-0.034622133,-0.03923571,0.083156295,0.07082435,-0.049484964,0.0068045165,0.026473844,0.03365127,0.02451006,0.006047763,0.05125863,0.013545335,-0.001745137,-0.0711424,4.445128e-33,-0.025284236,0.103136584,0.003382157,-0.08171725,0.035821997,-0.013090742,-0.054783206,-0.018523451,-0.033980004,-0.016549703,-0.03932895,-0.11020336,0.047427304,0.055988215,0.0038161576,0.021316193,0.013690474,-0.0057328977,0.003975661,-0.009180492,0.00793022,0.04842462,-0.053578075,0.038653545,0.023662405,0.071364984,-0.017245749,0.084165946,0.08967601,-0.032427892,-0.006162712,-0.06292768,-0.047712307,0.003785083,0.1259903,-0.02700218,-0.07317257,-0.040027626,0.053312168,0.04330413,-0.022017423,0.012200098,0.03472542,-0.0008589885,0.037244383,0.0075351447,-0.06434468,0.113561064,0.06278088,0.047445677,0.07718253,-0.039446782,0.107907906,0.021453775,-0.059526537,0.03433383,-0.027726077,0.041716114,-0.008548752,0.024020344,0.005193172,-0.03903247,0.007950855,0.06465387,-0.002087301,-0.009932359,-0.06583791,-0.04120222,0.007866222,0.03213984,-0.077143304,0.02766126,0.045176093,-0.0018327556,-0.011779153,0.06482434,-0.09948126,-0.06740491,0.06294359,-0.002689202,-0.08996072,-0.03956782,-0.0042322273,-0.05359704,-0.04233155,0.009206574,-0.06852984,-0.055550843,0.050930668,0.06846034,-0.015930895,-0.103013605,-0.11055277,0.03761089,0.012611449,-5.7339222e-33,0.07348878,-0.033221364,0.06557113,-0.042418372,-0.06857783,0.06468735,-0.0313345,-0.057137225,-0.0105965305,0.0028077865,0.042202163,-0.028004741,-0.04162388,-0.024766542,-0.029633053,-0.07113912,0.07333505,0.09485509,0.015330547,0.056145813,0.03910282,0.05191964,-0.04186842,-0.11096333,0.0025238867,0.0018244834,-0.010246813,0.058534823,0.044342734,0.027058689,-0.010570743,-0.037761223,-0.020357028,-0.030296702,-0.007458412,0.119013704,-0.019038921,-0.014774172,0.11099329,-0.003568272,0.101332836,0.0034692318,-0.027884344,0.09420958,0.03194996,0.0705436,-0.060663342,0.08360292,-0.012895466,-0.049044386,-0.0068397895,0.026157876,0.032812946,-0.0024806475,0.010923413,-0.0064418605,0.022065226,-0.060457185,-0.017289585,-0.07134401,-0.018484872,-0.068220384,0.01670307,-0.01615396,0.018370511,0.034649126,-0.046878055,0.06506437,0.10910488,-0.01414431,0.047736034,-0.017016815,-0.088911384,0.020589415,-0.06274141,-0.048202474,-0.053793374,-0.05769101,0.01491987,0.021537349,0.0029139793,0.029707443,0.051629942,-0.03406168,-0.010175957,-0.010139588,0.024132656,0.070587344,0.017077973,0.03587247,-0.020060496,0.0581469,0.017495781,0.04511943,0.051786378,-3.013476e-08,0.035202235,-0.028328562,0.059931226,-0.04490067,0.0012647689,-0.041331187,0.0111589655,-0.0022145694,-0.019335095,0.0076254345,-0.05071053,0.004588742,0.020535069,-0.019980617,-0.028890666,0.03468877,-0.067830145,-0.06261409,0.022292124,-0.051488426,-0.07468361,-0.031318948,-0.09068924,0.04163637,0.0038438055,-0.0724075,0.011178589,-0.009033973,-0.04106534,0.008759841,0.023915818,-0.02159302,0.0062402934,-0.017889265,-0.07755252,0.0044712196,-0.08212947,-0.061447788,0.0850014,-0.03943714,0.031906914,0.04566843,-0.07630643,0.052097913,-0.056283712,0.019073429,-0.037843797,-0.033885375,-0.038396396,-0.04407219,0.076657645,0.013211891,-0.04744251,-0.020570012,-0.053062312,0.0015313999,-0.019497743,0.002261496,-0.0593724,-0.057783652,-0.03468301,0.010433252,0.17273617,-0.09208561 +1.14.11.42,Requires Fe2+. The enzyme is not active with wybutosine.,384,0.99999994,0.00960974,-0.09394413,-0.09355819,0.07975035,0.087258026,-0.046105605,-0.026920184,0.030550871,-0.077199146,-0.040986992,-0.016554547,-0.044556763,-0.075703315,0.09197929,-0.024997404,0.035671614,-0.047253378,-0.08091558,0.03050419,-0.015734721,0.06691344,-0.0076189497,0.0768169,-0.057272438,-0.010629393,0.013171792,0.041514944,0.0022871117,0.003526249,-0.018876417,-0.020679733,0.0042135306,0.012879296,-0.054296628,-0.018509744,0.07481832,-0.026438674,-0.04933904,-0.050845426,-0.042464145,0.015896592,-0.01425274,-0.050799407,0.00244071,-0.06639233,-0.104477435,0.05562868,-0.01469429,0.074707136,0.095603146,-0.06122379,-0.078936405,0.010828831,0.037522487,-0.0029535869,-0.016557412,-0.033174727,0.013898943,-0.003653991,-0.04887254,-0.047656823,-0.023769433,-0.0019794905,-0.009283751,0.074553356,0.0074714045,0.00692922,-0.02318768,-0.033839177,-0.0072080726,-0.016172642,-0.03442846,-0.013779526,0.018959915,0.017789232,-0.010169352,0.059821915,-0.031987786,0.12727706,0.012682242,-0.074197836,-0.05398685,0.004141253,0.088205315,0.07500066,0.090709105,-0.07370016,-0.0063197664,-0.05369765,0.052479703,0.015819337,-0.008830947,-0.03142674,0.04306829,0.04346833,-0.0058974917,0.019582314,0.04355895,-0.06973246,-0.007226321,-0.088490434,0.017492926,-0.01496932,0.01902828,-0.013165293,-0.011481802,-0.006875306,0.08914521,-0.042823862,-0.040207405,0.023168432,0.012946081,0.10781723,0.035910785,0.010938732,0.076004766,0.029184798,-0.020365778,-0.060253847,-0.022396203,0.07015703,0.055166885,0.022797372,0.029452033,-0.098512985,-0.006870007,0.0074295066,1.6240404e-34,0.09021967,0.019359235,-0.0005014837,0.0044678096,0.0015664687,0.03351548,-0.06666942,-0.02728446,-0.037746977,0.000488724,-0.103052095,-0.11039482,0.07493699,-0.006011353,-0.010516072,-0.088442065,0.047714926,-0.020202672,0.07046452,0.09349794,0.088411175,-0.0065074554,-0.039569385,0.013642775,-0.060705822,0.08870424,-0.044189326,0.071916,0.048852596,0.023680883,-0.010028755,-0.117805965,-0.051455427,-0.031446416,0.036054827,0.026474707,-0.029584592,-0.019522727,-0.015026574,-0.065555766,0.015365483,0.044625804,-0.0049834806,-0.023480425,0.12049579,-0.05880521,-0.025775535,0.13541988,-0.017366972,0.14082745,0.024078414,0.0003640105,0.07157399,-0.019497372,-0.047739074,0.027808232,0.034326296,0.029942552,0.054571405,0.038816128,-0.030162057,0.050936364,0.042870715,0.035874657,-0.01830958,0.017198002,-0.064303905,0.034167554,-0.06733255,0.11925306,-0.04126545,0.042859353,0.04962162,0.049369153,0.06637376,-0.053408977,-0.004756141,-0.04946929,0.048654277,-0.010720677,0.06400327,-0.025748977,0.0013171837,-0.012507563,-0.04139457,0.0068788915,-0.07426761,0.0063806805,-0.018203484,0.043554515,0.060559336,-0.05066593,-0.020130089,0.010227797,-0.016108438,-1.2809939e-33,0.033293508,-0.053788085,0.05533688,-0.04871982,-0.05344741,0.047104035,0.00798025,-0.12199103,0.033071145,0.00382661,0.100011945,-0.036563486,-0.061443094,-0.013928853,0.034905437,0.10159974,-0.06946809,0.01705316,0.080662735,-0.0040952954,-0.047124512,0.12906425,-0.029913139,0.03343488,0.01998363,0.0119364485,-0.021244599,0.052021567,0.041970532,0.044737972,-0.03831123,-0.026305389,-0.08910972,-0.06892575,-0.0031300446,0.005553398,0.005541474,-0.049692027,0.037458118,0.005215667,0.015808975,0.03348478,-0.057125278,0.102136694,-0.010962447,0.08447664,-0.052754536,-0.0132835265,-0.0389879,0.029829219,-0.016778868,-0.015429564,-0.054271076,0.0047534057,0.006992094,0.009764311,0.07862707,0.022603437,-0.061040863,-0.002388382,-0.01338776,-0.047471035,0.025800226,-0.01975206,0.032052238,-0.02433565,-0.0493997,0.17394684,0.04013391,-0.036786392,0.044588722,0.074739255,0.09512493,0.00970964,0.016205326,0.013949187,-0.06920743,-0.0017090366,-0.016001062,-0.04008672,0.0052682976,0.07200555,0.015050368,-0.089157894,0.024193142,-0.09470379,0.017460153,0.07289577,-0.033048242,0.04008428,-0.019255595,-0.0118308915,0.020856513,0.031828005,0.07040205,-2.0764153e-08,-0.07260959,-0.0030395114,0.004600336,-0.0764012,-0.013119365,0.0011531343,0.002434123,-0.07318809,-0.027902335,-0.023747545,-0.064069875,0.0736734,-0.028223429,0.052078992,0.005971426,-0.021776158,-0.05316651,0.03545313,-0.008847671,-0.04605258,-0.08229321,-0.021476716,-0.09930964,0.0612416,0.019249376,-0.047817588,0.015491036,0.00688736,0.00032029516,-0.02318318,-0.01967699,0.018224344,-0.04875142,-0.020851014,-0.12309868,0.013544823,-0.018818324,-0.0040037497,-0.065647095,-0.00088542764,-0.037676435,0.038446378,-0.01043276,-0.029103799,-0.009219367,0.0083377985,0.014430608,0.024677074,0.0044454006,-0.012897509,0.073722355,-0.06280076,0.05203039,-0.07897123,-0.034555443,0.041776065,-0.0023194195,-0.046287246,0.027965972,-0.1027999,0.004339163,-0.024037085,0.16152552,-0.065016665 +1.14.11.43,"Fe2+-dependent enzyme. The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (S)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop [1,2]. ",384,0.99999994,-0.042130556,-0.056963783,-0.05536984,0.01646049,0.18630505,0.016312337,-0.007957179,0.03561063,0.026941609,-0.023272844,0.016006952,-0.012048283,0.008028883,-0.02288032,-0.016700046,0.06064885,-0.020761209,0.052080378,-0.0054832995,0.04589008,0.043632887,0.031172633,-0.09161508,0.030270416,-0.05424462,0.022704441,0.043821286,0.01869775,-0.07957715,-0.056938298,0.005308275,0.07325187,0.050836034,-0.084553935,-0.006711456,0.1323345,-0.079278536,-0.026409633,0.07885995,-0.0043803304,-0.0858106,0.02711205,-0.029769141,-0.076756075,-0.081115045,-0.1131159,0.018999549,0.039483733,0.030563146,0.0008280574,-0.008467788,0.05959894,-0.023494145,0.026887322,0.04538257,-0.0726461,0.023665043,0.041518606,-0.121831894,0.012681964,0.024141656,-0.034704316,-0.0038674579,0.0073867836,-0.031539597,-0.016033795,0.043113206,-0.03076946,0.035052944,-0.003610897,-0.084172875,-0.051874135,-0.029458463,-0.06437149,-0.041758027,0.08565106,0.054424655,-0.0016601967,0.08281271,-0.09549329,0.034455076,-0.015144734,0.039394043,-0.03241699,0.033514634,0.013881878,-0.058298476,0.006359337,0.06978021,0.096502125,0.071402855,0.07545143,0.0045605614,-0.04681379,0.00478684,0.049461074,-0.056136698,0.017412689,-0.047479633,0.042788412,-0.041048564,0.07746959,-0.026373306,-0.06189857,-0.0211366,0.02514718,-0.033877183,0.05448033,0.018391073,0.07793313,0.04347065,0.0065009473,0.04239743,0.021885667,-0.001151126,0.05697392,0.0842186,-0.04317571,-0.026900804,-0.041284233,0.041610774,-0.024525689,-0.03437242,0.0012347895,-0.06019884,0.04944596,-0.05863831,3.7694677e-33,0.027705802,-0.051704116,-0.007161628,1.5923612e-06,0.0011249958,0.009810041,-0.057970308,0.009137853,0.0073495023,-0.02337091,-0.06835326,-0.10354578,-0.014224928,-0.05949046,-0.020995768,-0.0498837,-0.032211468,0.039226584,0.052997954,0.02621285,-0.00917631,0.075846426,-0.07054512,-0.07525155,0.01132521,0.0608735,-0.047970716,-0.02778642,0.01076827,-0.016658224,0.065456145,-0.041804355,-0.15044735,-0.0052795224,0.07068139,-0.06287014,-0.025372269,-0.02351841,-0.007011975,-0.012002869,-0.012089941,0.1031973,0.034139838,-0.034463502,0.008310301,-0.059628718,-0.041096494,0.122078255,0.032680184,0.09988823,0.018532423,-0.013945288,0.035123304,-0.06167465,-0.03447961,0.012874681,-0.029160574,-0.0018946411,0.06836783,0.067289196,-0.015526394,0.07206618,-0.0041044597,0.014053095,0.069576286,-0.10600455,-0.059921958,0.095788054,0.076210864,0.09304394,0.0013546927,0.017202033,0.058557108,0.041147023,0.019201726,-0.10802757,-0.052251495,-0.05303568,0.05362593,0.05889955,0.06479928,-0.028726636,0.01536156,-0.057999223,-0.08030614,0.07955157,-0.08887095,-0.040186245,0.04992157,0.00059444946,0.06399641,0.024923218,-0.09289109,0.031040084,-0.00044471436,-4.5437684e-33,0.010337234,-0.050688878,0.0597653,-0.01805655,-0.107474804,0.04714082,-0.039178327,-0.011398226,-0.039481897,-0.0014152911,0.062481735,0.051291864,-0.0077919676,-0.085277416,0.030562425,-0.01997564,-0.005921109,0.034071967,-0.045982312,-0.0421506,0.002834855,0.042391893,-0.03381712,0.0046404293,-0.023755057,-0.003933699,-0.044629585,0.06771566,0.063910395,0.08714988,0.07009008,0.03781109,-0.061599873,0.007927956,-0.008244761,-0.06590251,-0.08779384,0.0019889057,0.02690307,0.03253531,0.026547803,0.05610552,0.0138185285,0.08657261,-0.02429185,0.010354711,-0.061358333,0.046983372,0.055407777,-0.0007732831,-0.051638335,-0.012082836,-0.06389676,0.003628957,0.019399248,-0.06857386,0.07554119,-0.0034045929,-0.06745052,0.05488911,-0.038377438,0.03476043,-0.011189823,0.014654662,0.050406903,0.08036674,0.02101673,0.09586013,0.084744796,0.008095284,0.00862661,0.015637632,0.033523817,-0.05174967,-0.0039970875,-0.006056987,-0.013415259,-0.022381611,-0.0013294336,-0.027611662,0.097216524,-0.01253655,-0.02997468,-0.0700419,-0.043529376,-0.115945205,-0.052321896,0.023335084,-0.0013876944,0.011163546,-0.02113072,-0.019801736,-0.012468639,0.033316854,0.037045147,-3.7825398e-08,-0.059780024,-0.061051857,0.05874189,-0.024496568,-0.03491164,-0.027088398,0.0037210118,-0.0078739235,0.041740835,-0.043127984,0.01276325,0.07021825,-0.01767111,0.017137311,0.065234154,-0.02795681,0.052936636,0.049185283,-0.026092349,0.009955662,-0.09589069,-0.015940571,-0.12868534,-0.021108003,0.052641198,-0.030868683,-0.032896727,0.008367521,0.08777226,0.055668946,-0.006246256,-0.0045614974,-0.031262424,0.0059930356,-0.023409693,-0.026722679,-0.108113155,-0.026456725,-0.03631638,0.03757798,-0.016460346,0.024786094,-0.0810882,-0.018918477,-0.011565773,-0.023720628,0.010241866,0.05302029,-0.04138216,-0.00772996,0.056263655,0.014244419,0.060970366,-0.038598564,-0.07179527,0.06786951,0.026509702,0.0079968255,0.027020516,-0.06800426,-0.043577246,0.002739465,0.14522232,-0.061368424 +1.14.11.44,"Fe2+-dependent enzyme. The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop [1,2].",384,0.99999994,-0.041242987,-0.05576135,-0.05998342,0.013651387,0.18961397,0.014729483,-0.0068814657,0.03791709,0.025519522,-0.024377747,0.011331525,-0.009281254,0.006401937,-0.017878795,-0.011624587,0.061467946,-0.02360554,0.051532164,-0.01060956,0.046298586,0.040570978,0.038576607,-0.08816587,0.030941777,-0.053755645,0.023560101,0.04725212,0.020419305,-0.07654637,-0.055611763,0.011547118,0.074004784,0.051112667,-0.08453635,-0.011985027,0.13175136,-0.08332077,-0.028936563,0.0862978,-0.0049699615,-0.08853998,0.033882797,-0.025926525,-0.07336751,-0.08376739,-0.11418343,0.0143636465,0.04352368,0.032996114,-0.00028721883,-0.010068646,0.0665316,-0.022320211,0.030146902,0.05012065,-0.07243494,0.016262976,0.03931102,-0.12125325,0.0115174055,0.024299234,-0.033360846,-0.0031912182,0.009040397,-0.04154758,-0.01590482,0.040286098,-0.028805058,0.044071082,-0.0025298013,-0.08730636,-0.049084317,-0.030952679,-0.07404695,-0.03936584,0.08884126,0.055181276,0.0016465309,0.07696486,-0.09397809,0.034102593,-0.013777823,0.039752193,-0.035814896,0.031026643,0.014575844,-0.049125362,0.0013460418,0.06997681,0.093239225,0.08172338,0.083012775,0.00828219,-0.04943044,-0.0033505822,0.04918835,-0.055708572,0.01508966,-0.045498688,0.043947257,-0.041023098,0.076426536,-0.029614083,-0.059600443,-0.032603066,0.02327949,-0.03748557,0.05763835,0.019875577,0.07513621,0.042417657,0.0053593786,0.037626043,0.02606873,-0.0056291413,0.054827478,0.07852584,-0.04374986,-0.028320776,-0.03945614,0.037390973,-0.022761097,-0.035807535,-0.003799119,-0.060068738,0.04820685,-0.06416751,3.742904e-33,0.028924221,-0.05027165,-0.0081886165,-0.0054086614,0.0022960363,0.010374725,-0.060606916,0.009609459,0.009712868,-0.024970556,-0.06306421,-0.10163507,-0.01337828,-0.06434751,-0.025260685,-0.044646844,-0.033004485,0.040348217,0.047581848,0.032767404,-0.0074211527,0.07934876,-0.07000938,-0.07131294,0.0070399405,0.06369452,-0.04322049,-0.026525788,0.013584638,-0.017343964,0.067371234,-0.040404424,-0.15201546,0.001035861,0.0680863,-0.068702064,-0.027699223,-0.024585973,-0.0035731501,-0.011867053,-0.010440237,0.103921,0.031800695,-0.028045839,0.009603008,-0.060849994,-0.034637976,0.1254633,0.03419315,0.1065994,0.017098162,-0.011852929,0.039049894,-0.060913473,-0.031385392,0.009704274,-0.03287801,0.0044858255,0.07349983,0.06356359,-0.016958358,0.07266347,-0.0031166228,0.011980281,0.066585876,-0.10721881,-0.059251,0.0886879,0.07925077,0.09703959,0.005389067,0.010016031,0.058490153,0.042268313,0.021581938,-0.10530616,-0.053420227,-0.058255363,0.053440873,0.06023067,0.059927154,-0.020228358,0.018454056,-0.062366553,-0.07697027,0.07385271,-0.088891976,-0.042409115,0.050966304,0.0034093056,0.06667489,0.019873533,-0.09552073,0.027749877,8.571474e-05,-4.4636334e-33,0.015222715,-0.0519522,0.058390964,-0.012436512,-0.108081646,0.039898437,-0.038773704,-0.013351728,-0.032934535,-0.005133209,0.06702502,0.052843302,-0.008209107,-0.07277759,0.0375767,-0.024171693,0.0029503235,0.03466582,-0.05170842,-0.039831813,0.002726548,0.03800329,-0.033936556,0.0033938412,-0.026868131,-0.0031851267,-0.039239828,0.06631475,0.064418614,0.07846428,0.06789189,0.042902082,-0.06285381,0.0113277575,-0.008653139,-0.063807085,-0.08225699,-0.00085369893,0.023358664,0.035389554,0.024501171,0.05680044,0.009976777,0.08413984,-0.02838053,0.00086537446,-0.061990775,0.048217677,0.054004427,-0.003875437,-0.055325545,-0.0113052195,-0.060187142,-0.0003348471,0.016527707,-0.06855392,0.07418532,-0.0010479972,-0.059547517,0.05723604,-0.034296487,0.032915995,-0.012003591,0.019096594,0.044254642,0.07685792,0.029946802,0.09597895,0.08444666,0.009921291,0.010085989,0.019503241,0.040333446,-0.051010296,-0.008549519,-0.0069820043,-0.011013731,-0.028169638,-0.0017221108,-0.02841954,0.09909389,-0.01369077,-0.030297248,-0.06993814,-0.044281177,-0.11452806,-0.057004787,0.019005025,-0.0029405837,0.011143754,-0.017796068,-0.024251778,-0.012288238,0.038783893,0.043917567,-3.7856672e-08,-0.05513676,-0.063411,0.05844019,-0.024372766,-0.025284149,-0.02534697,0.004475474,-0.015481452,0.037550777,-0.038467348,0.015469631,0.06453291,-0.020607814,0.014922453,0.061938312,-0.027708316,0.052447405,0.0499312,-0.027153075,0.011678127,-0.09743611,-0.018705022,-0.12900285,-0.021260226,0.058249217,-0.031552516,-0.029675132,0.008345689,0.08394109,0.051878396,-0.00425693,-0.004399016,-0.022540659,0.007864175,-0.026749944,-0.028772956,-0.10185153,-0.018960832,-0.043029808,0.035364013,-0.016782444,0.027949173,-0.083438784,-0.020277424,-0.015004961,-0.027142895,0.004280892,0.05129188,-0.0424853,-0.015613956,0.055648778,0.017379547,0.05696418,-0.037444018,-0.075208366,0.06640335,0.017564798,0.014633749,0.020023724,-0.067871235,-0.048664406,0.004464562,0.13866743,-0.06818228 +1.14.13.180,"The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The enzyme from Streptomyces purpurascens is an FAD monooxygenase. 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C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogues (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position. 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The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.",384,1.0,-0.077834226,0.022682296,-0.0506191,-0.029919976,0.051550362,0.051195573,-0.026286693,0.00050900585,-0.030410463,-0.009680515,-0.008259304,0.0035241393,-0.07443695,-0.00072638254,0.010160482,0.06335238,-0.06673706,0.014215925,0.06677314,-0.034975667,0.026266415,-0.04895493,0.02063078,0.0018318613,0.025214108,-0.0073509156,0.045799274,0.048092887,-0.09327877,-0.04277009,-0.012365461,-0.022659533,-0.020679707,-0.036382627,-0.0370874,0.0637593,-0.10760924,-0.09618717,0.015467334,0.049989406,0.040754512,-0.0666846,-0.08458312,0.023961904,-0.030524792,-0.038867444,-0.0048187803,0.036492072,0.025383756,-0.04650337,0.006087698,-0.06468575,-0.05057132,0.0051918076,-0.033150062,-0.08654933,0.01979546,-0.012557707,-0.040111147,0.00010027316,0.011530595,0.020741405,-0.07443832,0.0740642,0.031911306,-0.018654468,-0.0064126886,-0.030975124,-0.06670434,-0.02382704,-0.0045042173,-0.078642555,-0.085817456,0.021977771,-0.033911716,0.014529021,-0.022048429,-0.008010486,0.017986458,-0.028440002,-0.009318054,-0.045021717,-0.011140176,0.1137962,0.09042964,0.00132958,-0.058636155,0.050932642,-0.0353992,0.06309171,-0.064721845,-0.027565489,-0.0066030887,0.046850212,-0.062038563,0.09496159,-0.024999417,0.03702363,0.007002077,-0.01689328,0.031184502,0.1167558,-0.086330995,-0.08619883,-0.07802287,0.03065364,0.025914783,0.05884986,-0.0068117552,-0.027561054,-0.083327,-0.09251352,0.0045283716,-0.010154765,-0.024918443,0.102369845,-0.005672874,0.013371622,-0.016233673,-0.010683026,-0.00555331,-0.008730569,0.06424737,0.08576343,-0.03324338,0.023100685,-0.10734377,1.5993221e-33,0.10990908,0.038716488,0.005675329,0.07359202,-0.024706468,0.15991636,-0.012492841,0.011448355,-0.056779943,-0.069050536,-0.061212085,-0.028189093,0.013263401,-0.041175388,-0.006674529,-0.059318855,0.025305443,0.0752276,0.045517202,0.0025698068,0.0020227858,0.026511753,-0.06355401,-0.009273931,-0.0041626683,0.09118151,-0.04582132,0.052587133,-0.0052935397,0.015499218,-0.048263323,-0.08237392,-0.043838203,0.0044704652,0.019695606,-0.01987394,0.0058726408,-0.017751945,0.009096609,0.06995119,-0.039887,-0.07248706,0.047738343,-0.07605918,0.013903385,0.019632159,-0.08134217,0.06849074,0.0489454,0.07101831,-0.022364613,-0.0019436488,0.07698197,0.034367703,-0.090286486,0.05523968,-0.025804233,0.015450748,-0.04756723,0.018902399,0.09119119,0.084698714,0.035257597,0.02018854,-0.022517225,0.019482667,0.008042922,-0.057578534,-0.04738947,0.1565473,-0.07467606,0.042541742,0.12711841,-0.0043877955,0.07381785,0.03343,0.020955738,0.023602191,0.040101867,-0.018457502,-0.038142137,-0.001468496,-0.018645966,-0.010786388,0.03544348,0.018809399,0.0030890084,-0.04146876,0.06167846,0.08451876,0.013826613,-0.110739686,-0.014098378,-0.042980988,0.0026235653,-2.1759291e-33,0.053793192,-0.07476348,0.024615575,-0.14246078,-0.042588342,0.046447046,0.0866679,-0.04445628,0.00073751167,0.06299909,0.07621616,-0.071186036,-0.0011704251,-0.09469069,0.00015735821,-0.03731216,-0.008884586,0.018260755,-0.00048094158,-0.050372943,0.021300571,0.062682845,0.044956714,0.040455084,0.00603246,0.050540593,0.05525248,-0.027211325,0.09744791,0.04079272,-0.10598341,0.028860258,-0.0408903,-0.0015668918,0.01840843,0.11264386,-0.023406407,0.0653526,0.040488828,0.032125674,-0.028346905,0.073191606,0.012105609,0.018406823,0.060516015,0.07075435,-0.07493848,0.057526816,0.036376946,-0.022732843,0.03481019,-0.02082549,-0.018507605,0.013749791,-0.025828343,-0.012930151,0.0042332206,-0.0077168453,0.020312982,-0.0467321,-0.030058505,-0.028609311,0.0016503226,0.05078018,-0.0428801,0.016299699,-0.005754686,-0.03021686,-0.018991815,0.057874016,0.030376852,-0.07585529,0.007577247,0.1210223,-0.020957002,-0.056359846,-0.019018687,-0.04241102,0.029767813,-0.030593596,0.005767347,0.0073203784,-0.05522203,-0.048619993,0.0069330647,-0.09077139,-0.020044116,0.10175997,0.055791616,-0.016849617,-0.028282776,0.094469756,-0.024520349,0.062685095,0.017028399,-3.6986915e-08,0.022025354,-0.04131278,0.080446035,-0.0073853885,0.053910747,0.00024024444,0.022920707,-0.03118449,0.0976463,-0.090455025,-0.011873509,0.09165658,0.040242825,-0.021210354,0.07737522,-0.007786044,0.021129789,0.032662574,0.013120029,-0.057238203,-0.012732508,-0.018587671,-0.10051094,0.018242897,0.008255004,-0.012838959,-0.0032779346,0.025248308,0.082604855,-0.011053245,0.027569376,-0.006479378,0.0054239086,-0.018258607,-0.014709355,0.052444603,-0.05979041,-0.019308455,-0.029487267,-0.0104772225,-0.058950722,-0.10892039,-0.0035241717,0.031958126,-0.0075971796,-0.013271322,0.019484404,0.010088913,0.024860246,0.03802786,-0.03574242,0.008128972,0.038011607,-0.09585937,-0.08200917,0.007329554,0.040203813,-0.06950899,-0.00925807,-0.10744081,0.026300149,0.0039001347,0.17085859,0.02424881 +1.14.99.48,"This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin. The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % delta-staphylobilin, respectively.",384,1.0,-0.024318362,-0.007202988,-0.15159303,0.0623589,0.09237689,0.0050597475,-0.0028457064,0.08399321,0.0106509365,0.0042573847,0.032017138,-0.06613015,-0.04344555,0.02029919,-0.09261257,-0.03023296,-0.071095236,-0.004129133,-0.059736066,-0.069720484,0.03356149,0.101835445,0.010488088,-0.055881694,0.0008289089,-0.0034544053,0.08608984,-0.06759794,0.016031487,-0.029486917,-0.032269187,-0.044302978,0.083469264,-0.0055197515,0.0067357295,0.0836708,0.010484641,-0.084296554,0.008909711,-0.02334677,0.019070016,0.06172691,0.016076487,-0.00040278648,-0.04464401,0.014849536,0.0029764546,0.044455297,0.003816301,0.058205537,-0.024635987,0.016525246,-0.05509555,0.021685276,0.031239094,-0.006638372,-0.024260866,-0.046313006,-0.07060206,0.00094112504,0.040912513,-0.0053029647,-9.320398e-05,-0.022079201,0.050267052,-0.05841306,0.04620596,-0.055959754,-0.049316186,-0.11088193,-0.04755142,0.012269539,-0.06353451,0.058698144,0.0028325429,0.09244226,0.036426734,0.001128971,0.105541125,-0.010799702,-0.006139316,-0.00545177,0.061170366,0.11129942,0.036204223,0.042143796,-0.0037363805,0.048537064,0.011332495,0.038215972,0.038864814,-0.0149495695,-0.04329531,-0.08645118,-0.060636874,0.05361318,0.018405095,0.042336084,0.028003598,-0.037459545,-0.064694814,0.06638891,-0.032277554,-0.044609025,-0.06395382,-0.034750164,0.017240375,0.08534383,0.08062581,-0.004120601,0.063195735,-0.038582776,0.0701699,-0.00891832,0.03669533,0.10854623,0.07229694,-0.032973308,-0.074528344,0.0071248775,-0.006635886,-0.035071842,0.076484516,0.051926494,-0.01599301,-0.012881411,-0.108567275,1.2876571e-34,0.009960552,0.037263103,0.025257917,0.008133426,-0.01522191,-0.013036654,-0.07771065,-0.015622435,-0.04725519,-0.0053181755,-0.11571886,-0.08106823,0.08267716,0.032391403,0.018919783,-0.056843467,-0.022558397,-0.0068318653,0.05860494,-0.025843976,-0.0073726326,0.10219029,0.019425077,-0.018259348,0.05012512,0.049072713,-0.011395922,0.061848804,0.033349868,-0.00027779868,0.0028099576,-0.068017006,-0.13282141,-0.02460916,0.016886324,0.030198833,-0.024677945,0.01891557,-0.050480522,0.049166106,0.08142763,0.039390355,-0.015252371,-0.025362903,0.043059096,-0.06738938,-0.056137554,0.023453856,0.0021501381,0.06675015,0.0036732003,0.026016314,0.10060785,-0.02787217,-0.056133352,0.051975366,0.020961145,0.011138971,0.087144114,0.11886661,0.027318621,0.08686772,-0.038753334,0.09582024,0.029545384,0.035811253,0.04977471,-0.045522228,0.04376839,0.11269676,-0.037455752,-0.042102065,0.03066195,-0.020695,-0.08381339,-0.025061738,-0.034580823,0.061410856,0.056693327,-0.06632151,-0.042291146,0.03716541,0.018556876,-0.04468676,-0.10460127,-0.004406832,-0.031858094,-0.029112099,-0.116789505,0.016548676,0.09514033,-0.034479782,-0.077734366,-0.0058080596,0.013320514,-1.456922e-33,0.0024627917,-0.060802706,0.020405676,-0.10009113,-0.075323574,0.08460959,0.08760635,-0.02914245,-0.019092033,-0.031097833,0.096139774,-0.010011811,0.010474506,-0.0005526347,0.035577808,0.055763982,0.010120487,0.06604033,0.021262275,-0.0045659076,-0.019660108,0.10478929,0.03759617,-0.011151809,-0.0029380582,0.058187377,-0.07577621,0.039976068,-0.0037112408,0.015512239,0.0027518328,0.0177769,-0.037678942,-0.08979494,-0.09831355,0.0031088018,0.016776798,0.009070217,0.04396408,-0.025251562,-0.010756283,0.03587267,0.012804047,0.105735384,0.017822932,0.06254215,-0.041357413,0.013592454,0.0019249067,-0.037057348,0.013428885,0.015796715,-0.008690931,0.056642238,0.0105467625,0.060958657,0.008760009,0.019905819,-0.10030703,-0.0018017301,-0.026425129,-0.059969977,0.060350463,-0.0055956366,0.049672473,0.020334462,0.008179892,-0.011720685,0.023104927,-0.07879727,0.078282215,-0.015437295,0.0011279925,-0.010199158,-0.050248936,-0.042201884,-0.028991688,0.034190726,0.022949243,0.046967477,-0.042410534,0.0062026,-0.03356001,0.02873913,-0.0025744704,-0.1461763,0.07331003,0.06904184,0.011504723,0.014677205,-0.11780767,-0.01432155,-0.06055962,-0.008371781,0.03348399,-3.771981e-08,-0.037600294,-0.15164356,0.018035905,-0.0712653,-0.012797162,0.062462166,-0.08320698,0.015811054,0.0032667336,-0.032893553,-0.0069102934,0.06269536,-0.08595551,-0.022729976,0.03064149,-0.01305457,-0.052073065,0.012055136,-0.030693747,-0.061547738,-0.035281673,-0.023284977,-0.012552845,0.0031673682,0.018000877,-0.030139437,-0.022805491,-0.039069515,0.014480784,-0.03634653,-0.072392814,-0.030604798,-0.00010565362,-0.0052369814,-0.08768422,-0.027720477,-0.0017578704,-0.040415317,-0.00033051553,0.06028765,0.03374828,-9.889599e-05,-0.07397159,0.023584174,-0.044529505,0.05142971,0.0052387305,0.054252062,-0.041674174,-0.016547497,-0.009843189,-0.04327423,0.020536687,-0.025904017,-0.09402579,-0.0023717312,-0.024017228,-0.026369926,0.0066855126,0.05859038,0.046940926,0.0341408,0.15667512,-0.026596589 +2.1.1.288,The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin. ,384,1.0,-0.07772037,-0.0094683925,-0.18138851,0.038243312,0.039493453,0.0074652657,-0.058187682,0.008284813,0.026392605,-0.040331803,-0.05728756,-0.026396073,-0.056583982,0.05874569,-0.08579295,-0.013867983,-0.059776153,0.04128399,-0.01859422,-0.06455196,0.09621302,0.052783906,-0.0004836147,-0.009862266,0.065989226,-0.029685432,-0.0055919094,0.0034682634,-0.058218013,-0.017946476,0.022450384,-0.04067034,0.046430055,-0.08988112,0.05267787,0.13214256,-0.03645037,-0.0056362525,0.1613591,0.011163699,-0.0122529045,0.0056420024,0.017730804,0.06729382,-0.08327489,0.05704336,0.07114146,0.06183067,0.06791335,-0.04284458,-0.058734294,-0.021759888,-0.079582624,0.010248139,-0.008780006,-0.05125804,-0.03545237,0.010600613,0.017798297,-0.054718252,0.04750901,-0.046172295,0.04817305,0.030430717,-0.09900401,-0.055557523,0.035803642,-0.05548011,0.0360072,0.0056029777,-0.03790349,-0.010317393,0.017888851,0.04855714,-0.031679686,0.10479856,-0.022390686,0.009106576,0.00970057,-0.023118868,0.08495463,-0.023033366,0.025078392,0.13442047,0.03800736,-0.02553246,0.03227253,0.03438571,0.077705964,0.06271651,0.04878419,0.028987207,0.004482853,-0.031609356,-0.10706591,-0.06893649,0.00615425,0.026597383,-0.011260681,0.025641402,-0.02832056,0.03350048,0.051815372,0.011722524,-0.0417576,-0.06409074,-0.036263954,0.06395551,0.0035662926,-0.046802,-0.015088992,0.037884295,0.009059872,-0.036958277,0.00942477,0.04251783,0.012279335,-0.06898098,-0.047674783,0.01275796,-0.030153032,0.012608603,0.030646723,0.09254465,-0.042578958,-0.016418472,-0.08267111,1.857225e-33,-0.011638335,0.037600648,0.054191902,-0.07748283,0.0053577623,-0.0439209,-0.09124579,-0.0098157795,-0.0051038824,0.013676745,-0.029411742,-0.119086936,0.066323094,0.012557256,-0.013281309,-0.007995805,0.0048460457,-0.021307092,0.000809644,0.015356755,-0.0057991776,0.01858318,-0.07421841,0.038525574,0.06326715,0.05883336,-0.014450608,0.07786233,0.04336009,-0.024523573,-0.012924732,-0.10210236,-0.05546735,0.022489501,0.04964562,-0.035744924,-0.08578354,-0.013675387,0.06387491,0.030176077,0.017501086,0.021394348,0.011927616,0.038672466,0.06486974,0.034435757,-0.04932399,0.11597398,-0.0018362774,0.06799397,0.03416569,-0.04373624,0.1306357,0.017182633,-0.049331587,0.033326734,-0.020941941,0.050956998,0.040713143,0.052387282,0.019243352,-0.0058782757,0.005901344,0.022267323,-0.011282118,0.021510404,-0.002479059,-0.048957918,0.029014217,0.032057997,-0.026910283,0.029024463,0.0067342315,0.037198704,0.004211066,0.052540224,-0.06671635,-0.025101693,0.05622679,0.029294545,-0.073055655,-0.037569672,-0.042926975,-0.055698607,-0.0862001,0.10930546,-0.029201055,-0.08179354,-0.025856024,0.10120082,-0.005536726,-0.124046445,-0.063574664,0.037827663,0.047196973,-3.0222564e-33,0.07920778,-0.087018386,0.036793873,-0.057788286,-0.10274814,0.07890561,-0.06761727,-0.023249235,-0.07161738,0.018392049,0.032521944,-0.033294883,-0.026403619,0.059328835,-0.03574152,-0.012805057,0.034356315,0.09338376,0.021412734,0.06118588,0.046689965,0.09317248,-0.029858107,-0.067642964,0.047823712,0.015626771,0.004842638,0.08550251,0.023885865,0.05646438,-0.018577015,0.005413097,-0.052999776,-0.052141793,-0.031331442,0.062098496,-0.023192178,0.010106106,0.0776283,0.010705251,0.03586635,0.049270853,-0.025222803,0.101788394,0.010877932,0.08269234,-0.017454736,0.086740136,0.04482948,-0.0645011,-0.03928416,-0.00807757,0.021043248,-0.027137505,-0.030503333,0.024163187,0.017378286,-0.027385602,-0.04039583,-0.044939388,-0.033608902,-0.08378898,0.02570543,-0.014787234,0.053541884,0.04833472,-0.03625327,0.022536246,0.06690001,-0.03761036,0.0058362656,-0.03193447,-0.024808446,0.054054294,-0.078235626,-0.014953154,-0.017700728,-0.0025464394,0.029361162,-0.0066875527,-0.025027893,-0.0031524473,0.011889222,-0.069765516,-0.021167582,-0.0030155485,0.06547784,0.02996915,0.016948512,0.09831159,-0.045102533,0.053001948,0.006247944,0.029134795,0.020769022,-2.7069941e-08,0.08161594,-0.044766687,0.09792407,-0.07047479,0.022626549,0.018277735,-0.03054001,-0.01602963,0.0055538155,0.0010701464,-0.05246998,0.0034722947,0.009328716,-0.013978797,-0.07070155,0.0178181,-0.0862304,-0.054173395,0.017298901,-0.04478423,-0.021622568,-0.052093055,-0.09457303,0.05646819,0.056829106,-0.119160354,0.030886685,-0.019658849,-0.02790964,-0.014591453,-0.0018064632,0.01482059,0.019846858,-0.06119539,-0.01793029,0.017844966,-0.097220466,-0.094816,0.04243722,-0.052914917,-0.01949699,0.0038567956,-0.07580552,0.01979464,-0.028164074,0.034730673,0.004044405,-0.035005484,-0.017421866,-0.07985493,0.07114101,0.024848247,0.0014426572,-0.00026481543,-0.050764382,0.02434383,0.012646305,0.0182396,-0.04785632,0.046702918,-0.056575682,0.005620585,0.119725116,-0.10329477 +2.1.3.13,"The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate, and the subsequent carbamoylation of kanamycin and tobramycin. cf. EC 2.1.3.14, tobramycin carbamoyltransferase.",384,0.99999994,-0.09322439,-0.040246624,-0.13022992,-0.020266157,-0.022520212,0.12053291,-0.03695041,0.059174966,0.073102586,-0.020711029,0.033978947,-0.0073886844,0.064602606,0.033387102,-0.022890486,-0.011392381,-0.034645036,0.0601694,0.05248362,-0.032935444,0.06367895,0.05614968,0.044550363,-0.040384624,0.08976718,-0.03198343,0.0054027727,-0.011940737,-0.061255388,-0.04476458,0.040520553,-0.056449343,0.053831987,-0.06239939,0.12604898,0.014507307,-0.06400478,-0.08817374,0.12565781,-0.0026003383,-0.00090046757,7.743236e-05,0.011426886,-0.047893636,-0.051074095,0.024058048,0.0874859,0.0708972,0.016129412,-0.05540842,-0.05215618,-0.062469356,-0.020718325,-0.046723656,0.023287496,0.043924365,-0.016900215,-0.0047537624,0.0023572373,-0.05028966,0.042376816,0.013083631,0.044131443,0.018078363,-0.06718099,-0.037593607,0.00013932378,-0.07792093,0.018090816,0.015123505,-0.04216357,-0.02052747,0.043049958,-0.0015140257,-0.018623302,-0.014189701,-0.06339862,0.026170451,0.025575388,-0.051919915,0.042340573,-0.06252571,-0.00037067945,0.022870915,-0.017815541,-0.03827726,0.037488848,0.031189345,0.098894246,0.062295277,0.05391302,-0.03329359,0.02411996,-0.049364407,-0.1175113,-0.07525762,0.042713933,0.0067759817,0.05328143,-0.04182397,0.008046778,0.013156048,0.01630448,-0.06608759,-0.03760134,0.046755835,-0.007512712,0.073601976,0.059790377,-0.057379358,0.010495519,-0.022025725,0.052409276,-0.02927032,-0.07357526,0.043506436,0.050737526,-0.051325005,-0.12681241,0.03280372,-0.014236822,-0.07373302,0.040593587,0.06195574,-0.067673385,0.044804137,-0.08559098,4.9226684e-33,0.053537,0.05545288,0.00611768,-0.0002349915,0.026839826,-0.045825336,-0.08396486,0.0034500705,-0.01798287,-0.09657341,-0.0866183,-0.084756754,-0.014078611,0.03461201,-0.031669386,0.029535724,-0.11267709,0.015482829,0.030741828,0.022619821,0.019501803,0.0459731,0.026041621,0.06522281,0.051463164,0.068885766,-0.0045020664,0.012493149,0.08360649,0.0027871123,0.043976996,-0.07401363,-0.08065576,-0.043067873,0.11959969,0.013419777,-0.023259344,-0.022925803,0.04829953,-0.0039624968,0.0027683927,-0.0422176,-0.0435488,-0.03586815,0.048654113,-0.028189292,0.05886953,0.10882578,0.045713525,0.043176327,0.037879366,-0.04781758,0.08411519,0.008571387,-0.09799386,0.059625093,-0.020011405,0.011899572,0.01961488,0.012938168,0.012622408,-0.01017156,0.0410135,-0.03087498,-0.03335123,0.015265156,-0.026440328,-0.036512345,0.028748028,0.0063852184,-0.0014535745,-0.03513524,0.030013656,0.012660523,0.033208475,0.05178687,-0.029595785,-0.018343968,0.049737632,-0.056953542,-0.0059896843,0.0037976939,0.0007923617,-0.07883239,0.036547616,0.02322804,-0.047608897,-0.09170849,-0.048371296,0.13076906,0.0031008301,-0.091534555,-0.05478817,0.007559317,0.02799621,-5.83153e-33,0.06542082,-0.073716074,0.035668775,-0.042744443,-0.0270056,0.050773997,-0.0024674113,-0.0032782499,0.0090726465,-0.057566047,0.005557276,0.008054878,0.048401978,-0.05489901,0.015089547,-0.03881425,0.07261173,0.12195679,-0.06291463,-0.040562343,0.0098126475,-0.0064710146,0.006203425,-0.031975996,-0.0081739845,0.11621049,-0.040974192,0.07191617,0.083536595,0.07665963,0.052768327,0.007942258,-0.05416047,-0.03185021,-0.07484309,0.07895694,-0.01493375,0.021907618,0.03812037,-0.0010669235,0.021964792,-0.012844197,0.0016211122,-0.041430216,0.016815765,0.017529754,-0.044845156,0.004913821,-0.040482175,-0.04824851,0.038960584,0.017728036,-0.0069815214,-0.02604027,-0.01964384,0.059656724,0.05864462,0.0039006073,-0.026295971,-0.016074423,-0.06251297,-0.037363738,0.048940483,0.023196917,-0.00941873,0.035201106,0.035723392,0.04804773,0.08481603,-0.053695813,0.008665333,0.017554728,0.0051053204,0.0736506,-0.006603668,0.02730106,-0.09226043,-0.05265356,0.045971226,-0.065061785,-0.045027822,-0.052014295,0.019202797,-0.03815535,0.004859196,-0.017836647,0.03898012,0.033174217,0.06411891,0.048734885,-0.0185827,0.04934604,0.02164263,0.003960243,0.053142097,-3.8410565e-08,0.054742847,-0.060487214,0.069351405,-0.07254747,0.022759648,-0.0173334,-0.02981024,0.00016231019,0.028431972,-0.114935495,0.048301414,0.016117224,0.0050754165,0.0079757515,-0.003535252,0.031095615,-0.050323848,-0.041794993,-0.043602433,-0.039027542,-0.12053226,0.005512224,-0.06936694,0.08228898,0.05035215,-0.051021386,-0.011314244,0.04307661,0.0012716925,-0.04416732,0.061393596,0.00718195,-0.09954303,-0.050747663,-0.05651944,-0.0033733342,-0.023812171,-0.036896802,0.037895143,0.012771785,0.031302612,0.011078718,-0.07977679,0.05667801,-0.03493436,0.07120669,-0.061321393,0.049071774,-0.107231654,-0.011696731,0.0084570395,0.038005706,-0.12252622,-0.036228906,-0.15548484,-0.022117885,0.027702235,-0.022822192,-0.046218757,-0.028991835,-0.04686875,0.03706718,0.13938107,-0.08229393 +2.1.3.14,"Binds iron. The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate (see EC 2.1.3.13, ATP carbamoyltransferase), and the subsequent carbamoylation of kanamycin and tobramycin.",384,0.99999994,-0.06003046,-0.049020275,-0.12645377,0.093894705,0.0073055606,0.11113064,0.00531469,0.03847004,0.08462729,-0.06358793,0.012281179,-0.0039677317,0.030189106,0.0039265305,-0.03521534,-0.0573356,-0.016884487,0.04970766,0.02625694,0.025987765,0.034569163,0.037857853,0.0058767055,-0.09086609,-0.008150122,-0.0017852838,0.046688367,-0.0061224047,-0.058166664,-0.04037033,-0.04879047,-0.06356629,0.048900906,-0.037398305,0.047722302,0.03779421,-0.031785674,-0.11539058,0.056535646,0.008195064,0.012223484,-0.017084394,0.014413754,-0.042797666,-0.08184197,0.0012622044,0.13931112,0.09990844,0.009847814,-0.012958098,-0.06240029,-0.04169425,-0.03629881,-0.016275574,-0.005634099,0.020373797,0.02006976,-0.03139901,-0.007013294,-0.041053686,0.060453642,-0.006986737,-0.011416867,0.026216177,-0.03061052,-0.04493721,0.06551491,-0.058084033,-0.026310094,0.0023762616,-0.03261916,-0.016061595,-0.019520905,0.010340855,0.007325125,0.050943322,-0.041512914,-0.036276367,0.06251635,-0.069604784,-0.0145800635,-0.018885324,0.0070705935,0.07312669,0.01592689,0.018010909,0.02043319,-0.013410256,0.038894832,0.08852615,0.029114828,-0.0357493,0.008973772,-0.05659448,-0.10997797,-0.042362235,0.064333975,0.04667251,0.010865257,-0.029773807,-0.023802562,0.08211085,-0.025401257,-0.039734438,0.010442583,0.02763765,-0.039398152,0.0771199,0.013218639,-0.006237481,0.034598846,-0.05230717,0.057393074,-0.04005615,-0.018101059,0.066786274,0.08297583,-0.01659559,-0.12948003,0.025349895,0.01317207,-0.029901357,-0.010672428,0.05655487,-0.04467754,0.02187466,-0.13110515,5.8033293e-33,0.07273532,0.043155693,0.024712762,0.029661762,0.03143884,-0.017753607,-0.11468095,-0.050840694,-0.04885507,-0.014417719,-0.065845564,-0.070828974,0.064973,0.009616498,-0.03988624,-0.015691746,-0.103185646,0.005409945,0.063955896,0.050549906,0.04825125,0.0849772,0.08034667,-0.0035090183,0.019459335,0.11304204,-0.03999576,0.021705726,0.045527153,0.0021701949,0.061904278,-0.07908233,-0.1191976,-0.05653988,0.12828887,-0.03843148,0.0026244866,-0.034663595,-0.021148462,-0.051832724,0.03856346,-0.009852922,-0.09446857,-0.024260893,0.068044394,-0.09492526,-0.00068290904,0.15690392,0.018899592,0.043614212,0.033793654,-0.039850574,0.0981746,0.005526218,-0.087647505,0.051677946,-0.039831776,0.0148967,-0.010602001,0.08600571,0.055834178,0.009013604,0.04741083,0.030294986,0.052576672,0.057809167,-0.044777993,-0.03300674,0.06664925,0.057101227,-0.008831697,-0.009121034,0.08042567,0.03219428,-0.038355004,0.027936233,-0.075266056,-0.07323627,0.037316322,0.00585312,0.01185777,-0.04215743,0.030191915,-0.07291766,-0.05313208,-0.01189368,-0.07342924,-0.049796242,-0.028023135,0.021841984,0.03210404,-0.028945157,-0.044179194,-0.008517217,-0.0054864995,-6.784654e-33,0.073469274,-0.08056814,0.06232075,-0.009137258,-0.053151414,0.019853216,-0.03443667,-0.046549626,-0.024127835,-0.04115451,0.080517784,-0.011247189,0.02155389,-0.056091417,0.04301229,0.016789995,0.010782284,0.063214146,-0.03099525,-0.04622585,-0.050558772,-0.02013348,0.037111443,0.0182271,0.0050289277,0.04141478,-0.06297835,0.027610242,0.022442041,0.07890228,0.07305864,0.020503419,-0.06337559,-0.11177862,-0.08714298,0.038663242,-0.008300221,0.017461067,0.11929302,-0.0041984194,0.06808484,-0.04655802,0.0086703375,0.023862123,0.039578147,0.03527523,-0.06226503,0.020148296,-0.026700972,0.0041159797,0.03782207,-0.015326606,-0.04315639,-0.016187266,0.055107456,0.06345832,0.07490625,0.03424179,0.0032455295,0.026741952,-0.05267154,-0.026900183,0.08211686,0.044505652,0.009114983,0.054112516,0.037653543,0.057400864,0.049008295,-0.019300386,0.03471417,0.022507828,0.034974262,0.008794099,-0.0029205377,0.024240233,-0.051578905,-0.0011464079,-0.028244916,-0.008883739,-0.035484843,-0.04469969,-0.045021493,-0.026605392,0.029355567,-0.013294675,0.011300887,0.03233757,0.024975847,0.025371235,-0.052998163,-0.035326783,0.03977501,-0.052654117,0.001849052,-4.162534e-08,0.034702122,-0.02640295,0.07207414,-0.07272063,-0.0214443,0.009570788,-0.019889513,-0.017770385,0.0078591425,-0.05026399,0.047685932,0.050533053,0.030641928,0.008583526,0.04352564,0.030867526,-0.02035633,-0.029700868,-0.039322972,-0.06417925,-0.09199262,0.0011217336,-0.042746283,0.0848376,0.04956952,-0.10639355,-0.019077476,0.014429144,0.010809001,-0.047331713,0.031274654,-0.0045424677,-0.07966853,-0.06451718,-0.08630967,-0.028147064,-0.05766897,-0.02660586,-0.004913281,0.037685957,-0.011891701,0.022221398,-0.114990935,0.014044214,-0.02823173,0.10211984,-0.05232204,0.0770209,-0.11391255,-0.00794506,0.011395001,0.04928633,-0.014715466,-0.034554895,-0.12021282,0.06234314,0.03313267,-0.029524038,0.01408726,0.037730146,-0.096645564,0.0074205194,0.08543955,-0.10651836 +2.3.1.227,D-Perosamine is one of several dideoxy sugars found in the O-antigen component of the outer membrane lipopolysaccharides of Gram-negative bacteria.,384,0.99999994,-0.06039173,-0.078033656,-0.048276015,-0.06481866,-0.055759363,-0.025128564,0.0786278,0.08467355,0.026248641,0.09268077,0.013352518,-0.03198832,-0.010894814,0.022066629,-0.06509312,0.095950544,0.05901169,-0.03704135,0.0466806,0.084340654,0.066896915,0.023260238,-0.011595101,-0.042006794,0.014498227,0.09255734,0.034943532,-0.008435921,-0.012263712,-0.05124773,-0.07785409,-0.06863313,0.05703392,-0.034882404,0.08508742,0.0038191143,0.048126336,0.061071843,-0.026794944,-0.0332494,-0.003948674,0.041274652,0.037682023,0.042080387,-0.03312438,0.0059622196,-0.0098424675,0.07041675,0.06119076,-0.100032166,0.040742766,-0.08326162,-0.036851194,0.037257686,0.004546964,-0.021803888,-0.012650094,-0.0025716594,-0.0662269,0.0036178676,-0.028302914,0.030678548,0.083466955,-0.006494657,0.028839055,-0.055301573,0.043479905,-0.0016858985,0.03002575,-0.03866914,-0.009342977,-0.017111756,0.043239567,-0.0037246088,-0.00020510255,0.029896509,0.06500861,-0.0494203,0.045701835,-0.073168255,0.0222551,0.021052465,-0.0023207474,0.14176227,-0.060290705,-0.030434953,0.026643826,-0.024766145,0.07815433,-0.0034308233,-0.0711886,-0.06146796,-0.033203833,-0.017201105,-0.1346113,-0.060456295,0.024699157,0.015234345,0.09919408,0.002166925,-0.007365785,-0.041989725,-0.014990281,-0.056696292,-0.062472217,0.013246862,-0.0019079217,-0.015787741,0.03593308,-0.029809814,0.025266927,0.05212282,0.024511809,0.0659561,-0.101686776,-0.071752965,0.07580653,-0.054257013,-0.021008695,-0.035862613,-0.124669984,-0.05064384,0.03805449,0.03708985,0.058414668,0.034198996,-0.011314382,-1.0377747e-33,0.008955784,-0.033934515,0.03125272,-0.07116846,-0.022675551,0.022651223,-0.03729468,-0.028135493,0.002428222,-0.010547232,-0.07882124,-0.10439931,-0.006318641,0.059872966,0.013255672,0.055584814,-0.013547624,-0.054733638,0.050644293,-0.03178924,-0.042938612,0.11245418,-0.014298448,-0.08181783,0.07398105,0.059118144,-0.017546615,0.0035057233,0.035388015,0.0013607118,0.032137614,-0.020796109,-0.009860976,0.057239946,0.047252726,0.060911514,-0.051254306,0.025498584,0.03519066,-0.028425166,0.018736862,0.026038028,-0.015206084,-0.043782167,-0.003779155,-0.02209634,-0.04646155,0.06042233,0.0149937365,0.03898305,0.011507707,-0.06378162,0.020736815,-0.0028270576,-0.08897575,-0.0018205694,-0.06570311,-0.005536286,0.055842265,0.07337659,-0.0032726917,0.07313722,-0.06424209,-0.062218115,0.030306106,-0.05163059,-0.06706471,-0.005876977,0.04957157,-0.035109263,-0.01896879,-0.0646289,-0.020530803,0.036228817,0.0071452647,-0.049791437,0.044473793,0.06829383,0.072051704,-0.028855085,0.06320478,-0.06783993,-0.0023824247,-0.041382454,-0.06495699,0.13732323,-0.0051434655,-0.064899996,-0.044463545,0.09140706,-0.005741142,-0.06140381,-0.111316614,0.05718536,-0.065168284,-2.4005398e-33,-0.0405442,-0.085619435,0.07611294,-0.05123814,0.03542126,0.052010812,0.00679902,0.059407182,0.02888041,-0.025789717,0.017624408,0.01652282,-0.030478934,0.02977213,0.006347431,0.083387,-0.08482103,0.06185238,-0.035053026,-0.005080962,-0.08602241,0.04783625,-0.0039589186,0.04589175,-0.006698384,-0.024673887,0.051687937,0.06402435,-0.016037498,0.03432909,0.079772726,0.0303166,-0.025157407,-0.037375122,-0.031308316,-0.07957471,-0.040342696,-0.017987514,0.0023646115,0.016874017,-0.045415998,0.03793599,0.036707997,-0.0065567456,-0.014446672,0.0724037,-0.09737913,-0.014231303,-0.0025131481,-0.0015822037,0.0007622326,-0.062684745,0.117615506,0.010420679,-0.023673166,0.020866765,0.02084768,0.054317288,-0.0008087863,-0.035370704,-0.057485186,-0.10360397,0.021549745,-0.028675135,0.07158604,0.043012653,0.04284278,-0.009729351,-0.0003270259,-0.083887264,0.012947136,0.008766205,-0.07407783,-0.059229523,-0.04503391,0.0008842086,-0.09831449,-0.016783744,0.07232202,0.024614904,-0.02331636,0.00458166,0.021521302,0.048160106,-0.024870837,-0.00016145245,0.041805007,0.0561119,0.00022532728,0.07425664,0.022429118,0.06313773,-0.048781194,0.0068886764,0.12188612,-2.9104157e-08,0.086440526,-0.07227165,0.027143802,0.011132573,-0.04314562,-0.0030790034,-0.024893124,0.07526041,0.037240572,0.03936486,0.047685202,0.14638312,-0.018459849,-0.055320743,-0.040189743,0.0215614,-0.010381048,-0.05266605,-0.032570936,0.037233658,-0.11608016,-0.03643185,-0.06921345,0.011723724,0.00047566078,-0.0484746,0.06686566,-0.030008221,-0.023641728,-0.022148991,0.0041865674,0.05968183,-0.06967137,-0.1070948,-0.013022053,-0.0068184235,0.016876949,-0.081015915,0.0056970296,0.033155162,0.08993652,0.0031570895,0.04333379,-0.0044610724,-0.00527968,0.004446068,-0.053045332,0.07005286,-0.047782063,0.0093835,0.035157405,0.03305796,-0.08675182,-0.059900206,-0.13150395,-0.05298976,-0.03801446,-0.02516513,-0.016940042,0.025680196,0.035397884,0.0057346583,0.1062106,0.0009514369 +2.3.1.228,"The enzyme, found in the bacterium Bradyrhizobium japonicum, does not accept isovaleryl-[acyl-carrier protein] as acyl donor (cf. EC 2.3.1.184, acyl-homoserine-lactone synthase).",384,0.99999994,-0.08919362,-0.10665932,-0.1002098,-0.0204764,-0.002531235,0.054358955,-0.10948099,0.048732493,0.008271315,-0.08193232,0.13170482,-0.10344217,-0.05701947,0.06480022,0.0153682185,0.033807576,-0.052308902,0.055454593,-0.034126762,-0.06414565,-0.061526954,-0.0021452308,0.010174094,-0.046148814,0.07234606,-0.03597651,0.004647278,-0.0430091,-0.01355711,-0.083210476,-0.018721083,-0.08384593,-0.004254034,-0.08173598,0.124043204,-0.009491867,-0.017600244,-0.08400838,0.13742404,0.018818114,0.027966317,0.0010129174,0.032124046,0.0036137416,-0.040182542,-0.03467374,0.024321433,0.004425342,0.063868314,-0.03588002,-0.08017245,-0.015737059,-0.006005674,0.035199195,-0.07921027,0.055089954,0.05179847,-0.03583093,-0.049110573,0.012280735,-0.013531146,-0.015776753,0.045528244,-0.043423522,-0.06310855,-0.033040386,-0.005470632,-0.06614997,0.08204855,-0.013059272,-0.022505848,-0.10118991,0.029597852,0.07024012,0.011307885,0.02059328,-0.037665702,-0.00018158079,0.11246019,0.012402885,-0.03820877,-0.07990728,0.01757502,0.024435155,0.0365978,-0.044234313,0.024611367,0.047160942,0.00093713764,0.0399625,-0.0037335132,0.024473399,0.0025844194,-0.040208526,-0.16118346,0.025276419,0.020522607,0.07827344,-0.05902111,0.0025107546,0.02304478,0.053114977,-0.05456348,-0.056037586,-0.045893162,0.02193723,-0.07239777,0.04359808,0.00032400404,-0.06049429,-0.03006873,-0.0050251028,0.027997661,-0.02267968,0.02649991,0.042341568,0.0009506327,-0.05353418,-0.02835185,-0.009116568,-0.0302418,-0.02385025,0.054794263,0.054474536,0.027387926,0.028817736,-0.096441835,7.5176266e-34,0.08104102,0.09485014,0.038770717,-0.03933216,-0.049448553,-0.045078874,-0.09810004,0.08086398,-0.0790606,-0.07315292,-0.008481732,-0.08104863,0.023262247,-0.027287131,-0.037413765,0.008161435,-0.045807935,-0.052862834,0.039191134,0.037418924,0.07431782,0.030322349,0.00045066772,0.05761005,0.011574955,-0.005862365,0.035225544,0.04851483,0.052731205,0.047163792,-0.047027644,-0.05533212,-0.057667576,0.0528076,0.0685176,-0.024712272,0.023336621,-0.037217636,-0.055224065,0.052157532,-0.015351275,0.051290337,-0.0029144408,-0.033445995,0.1085108,-0.03471418,0.002296386,0.04705296,0.021093447,0.078826636,-0.02132623,-0.020596322,0.09883457,-0.004581265,-0.020544294,0.0120642185,-0.032347087,0.06631302,0.073280364,-0.025361473,0.02026104,0.044696566,-0.00065963506,-0.014757346,-0.06304083,0.08169105,-0.019833839,-0.043775555,-0.030295601,0.092133656,0.020665752,-0.041529637,-0.018034933,0.056406524,0.05295072,-0.08337808,-0.10928025,0.03528922,0.033181235,-0.052089278,-0.02149301,-0.042856213,0.031646855,-0.016650029,-0.04658372,-0.07412949,-0.008414821,0.060988564,0.03781894,-0.009976468,0.13039437,0.038976878,-0.03681777,0.041596677,0.046027165,-1.4241235e-33,0.13866998,-0.07963133,-0.009056942,-0.08028297,-0.051449552,-0.006775867,0.035638135,0.024981128,0.09489388,-0.0037367526,0.12623069,0.0025259727,0.0089782495,-0.10562476,0.009660261,-0.01853181,0.058841165,0.018079571,0.017717443,0.0068997378,0.0037001274,0.0030295684,-0.013679881,0.029062098,0.0453477,0.039576735,-0.04494407,0.083760604,0.055723805,-0.0045308117,0.036242984,0.024778806,-0.043441053,-0.09418741,-0.020350402,0.017699255,-0.021185657,0.01965215,-0.0017467035,0.02816459,0.0058074174,-0.02093764,-0.034684505,0.11331139,0.028659511,-0.0074813114,-0.049041066,-0.009790547,0.029787539,-0.076315045,0.02817625,-0.041670308,0.05079802,-0.047875654,0.0042296345,0.0942138,0.0041463855,0.019912845,-0.0277878,-0.006517097,-0.020888638,-0.029044634,0.02037962,-0.003553363,0.03432788,0.05799173,-0.018407162,0.07207124,0.003368703,-0.0066356147,0.07985104,0.06271502,0.016680347,0.08647099,0.028376136,-0.017682724,-0.030450778,-0.005493541,-0.01585689,0.0018862063,-0.024256568,-0.029049221,0.028943833,0.013328458,-0.013668473,-0.018828211,-0.0007720897,0.023134882,-0.0038707966,0.031112555,-0.022194043,-0.01218838,-0.04036056,0.06296952,0.06341931,-3.740522e-08,0.024108222,-0.022604411,-0.010715398,-0.055608246,-0.0033102436,0.036443345,-0.042508055,-0.085646525,0.06456315,0.0362416,-0.048480228,0.10682152,-0.007857153,0.08552783,-0.059118494,-0.0022106722,-0.036778513,0.0066285837,-0.018852834,0.016564893,-0.05873995,0.002901611,-0.055053186,0.0121180825,0.022846822,0.037902746,0.010490305,-0.029138463,0.0021269259,-0.052808765,-0.01648844,-0.021476386,-0.012680328,-0.008056201,-0.006249926,0.032322474,0.026286772,-0.07329745,-0.048027005,-0.013258662,0.059516646,-0.018181676,-0.12978646,0.011667983,0.13604172,0.032775633,-0.0025888619,-0.015180424,-0.07575823,0.0070322934,0.07381837,-0.031954546,-0.044001497,-0.020771377,-0.057237852,0.031758163,-0.02274759,-0.06840156,-0.027724227,-0.030740567,0.011980497,-0.042586852,0.18480065,-0.026620202 +2.3.1.229,"The enzyme is found in the bacterium Rhodopseudomonas palustris, which produces N-(4-coumaroyl)-L-homoserine lactone as a quorum-sensing signal.",384,0.99999994,-0.011647176,-0.05761086,-0.093937494,-0.0074966135,0.026154254,0.096544065,-0.10785644,0.04476887,0.05168596,0.008854583,0.009919089,-0.104759395,-0.052777484,0.05795325,-0.02886026,0.046023056,-0.041160893,0.020129321,0.041483816,-0.069535114,0.07517314,0.09685165,0.0029024568,0.004726686,-0.004466394,-0.028343534,0.044225506,-0.041086137,-0.020678604,-0.038937904,0.03632211,-0.05649279,0.1129841,-0.030095244,0.06030296,0.043131173,0.053504884,-0.10527755,0.13221279,0.041996703,-0.019640783,-0.001251585,0.07447632,0.018200722,-0.007698951,-0.01440206,-0.028816411,0.051646903,0.06426241,0.0071180784,-0.08404824,-0.047199637,-0.028831135,0.012985914,0.05486059,0.07020523,-0.046223164,-0.06481913,0.055112332,-0.016886361,0.097506404,0.0048742867,0.024279276,-0.03155528,-0.03740986,-0.017956894,0.035446215,-0.07291609,0.07000327,0.0069200317,-0.023956792,-0.05189767,-0.0029036852,-0.07145841,-0.015949342,0.039837725,-0.017987806,-0.056012396,0.04822989,-0.0042089797,0.04529588,0.01263183,0.0023559292,0.07175635,0.013481059,-0.032416493,0.09098121,0.0046292474,0.050273236,-0.05483934,-0.05380951,-0.043444447,-0.12953001,-0.041044306,-0.17526288,-0.010999958,0.0038968183,0.11561371,0.0124384845,-0.03928941,-0.033835728,0.0030900887,-0.027272334,-0.050478265,-0.11203441,0.021035329,0.015452137,0.07145721,0.07592681,0.020180011,-0.04110909,0.039791714,-0.06485964,0.04780038,-0.014788591,0.08174578,-0.0028641988,-0.053072125,-0.10143513,0.035667557,-0.002022568,-0.054199837,0.052318417,0.0005240886,0.023931148,0.08149884,-0.07622984,1.2051124e-35,0.07523705,0.057176802,0.054045532,-0.073602654,0.013925963,-0.05874013,-0.13093513,-0.0016243709,-0.021977391,-0.07870141,0.022266963,-0.010944419,0.023699941,0.015670193,-0.013524289,-0.040435206,-0.036509838,-0.056931816,-0.0059169144,-0.0019897057,-0.03707972,0.07835312,-0.021457918,0.09125529,0.0042014234,0.0414872,0.07655438,0.010574651,0.07644647,0.011380182,0.039089523,-0.053075723,-0.037201926,0.01081591,0.08087706,0.025010439,-0.041060224,-0.010037525,-0.029510321,0.037455965,-0.0042733876,0.019958237,0.007003128,-0.03332086,0.04157718,-0.078490674,-0.0971895,0.050339248,0.022941036,0.065194294,-0.027567286,-0.032447636,0.06306906,0.06605482,-0.0060964194,-0.011702094,-0.069339275,0.010646435,0.08024319,-0.028521987,-0.016899668,-0.07902873,0.0433278,0.02689163,0.05771883,0.07462028,-0.028520303,-0.08657296,0.08227801,0.047373146,-0.0107666515,-0.021934068,-0.029090393,0.05120824,-0.0014670078,-0.025329694,-0.06375768,0.020182576,-0.04438307,0.00028544434,0.018555524,-0.037125394,0.030103967,-0.025662709,-0.036582597,-0.05040912,-0.017370062,-0.032768264,-0.015810914,-0.04152805,0.040526107,-0.01574698,-0.012681927,0.013790936,-0.020932395,-1.16996365e-33,0.06359389,-0.06678399,0.0378834,-0.012887846,-0.07092592,0.03860288,0.046486642,-0.011534718,-0.018596275,-0.027789187,0.09295428,0.017108493,0.04287498,0.032619145,0.020335434,0.061114464,0.049530357,-0.021522816,0.025953801,0.023314904,0.016544156,0.0137285935,-0.017345631,0.019021891,0.08811263,0.08153461,-0.035850324,0.017502183,-0.028055266,0.027778588,-0.015999595,0.011457812,0.0012866127,-0.06140289,0.006354305,0.058637977,-0.0046668495,0.027171317,-0.017094808,0.04358184,-0.02167964,0.06690303,-0.004802557,0.05213194,0.0052792965,0.038750086,-0.014600045,0.047229823,-0.047982935,-0.062456764,0.0076768855,0.008544914,-0.025220912,-0.056683615,-0.012134165,0.110845156,-0.014210317,0.013106177,0.018404173,0.030378101,-0.0588209,-0.042575322,-0.010535537,-0.011243193,0.020855011,0.063448176,-0.0046125157,0.0049945414,0.042997766,-0.009554539,0.024916494,0.08518743,0.03638889,0.08168672,-0.06361214,-0.03085396,-0.13101375,-0.13219929,-0.092673354,0.027241489,-0.02745463,-0.07287806,0.041690055,-0.042929143,-0.005306732,-0.09664061,0.037852027,0.038910773,-0.025178375,0.056854937,-0.04859384,-0.023363534,-0.07953867,0.053897075,0.120323725,-3.1508463e-08,0.051046163,-0.06467529,0.06012891,-0.056923315,0.05713925,0.06240174,-0.016223026,-0.05049436,0.07756569,-0.023579655,-0.03423377,0.022070844,-0.046451632,0.028163787,0.015924627,-0.003555002,-0.0086960485,-0.024154205,-0.07547606,-0.002074887,-0.03547421,-0.023323918,-0.09721422,0.025150487,0.027063653,-0.04110078,0.033377703,0.022650735,-0.06226096,-0.07411718,-0.010515579,0.09789465,0.08394449,-0.021978233,-0.10179477,0.06636721,0.0049506715,0.013696959,-0.04589031,0.023872284,-0.0044065937,0.002019683,-0.085109085,-0.01896178,-0.020216238,0.02090524,0.037550982,-0.016990475,-0.05230603,0.042861026,0.0041763317,-0.011449977,0.0038578247,0.0025603469,-0.088383354,0.016953273,-0.045844153,-0.046098527,-0.024377154,-0.035984006,-0.019347971,-0.022152891,0.1570201,-0.048845872 +2.5.1.111,The enzyme's product feeds into the biosynthesis of the aminocoumarin antibiotics clorobiocin and novobiocin [1]. 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+3.1.1.95,The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species.,384,1.0,-0.024590759,-0.0030587679,-0.19570267,0.04236423,-0.012240182,0.05147662,-0.082323216,0.017406039,0.049208254,-0.06295794,-0.049231388,0.006025567,-0.017925564,0.0062148087,-0.06860336,0.0069797747,-0.083378114,0.0943571,0.033074096,-0.046094585,0.067391366,0.011436501,0.049472794,-0.040763143,0.09359116,-0.04504242,-0.028377732,-0.026199793,-0.05452187,-0.045770284,0.03186013,-0.039741475,0.050154723,-0.082011856,0.0782016,0.09260283,-0.080790766,-6.174813e-05,0.13015549,0.011555446,0.002511958,-0.014773327,-0.032378633,0.036159635,-0.081205234,0.054933812,0.02643365,0.03517051,0.017024387,-0.0017313374,-0.06713729,-0.036958907,-0.0835121,-0.021289507,0.010208251,-0.06680981,-0.010060911,-0.0035495805,0.0040292996,-0.042235337,0.13819313,-0.034656473,0.015580654,0.011433454,-0.10628052,-0.07061035,0.074683145,-0.058054235,0.049823724,-0.011513356,-0.027378479,0.0058109374,-0.0136205,0.031041041,-0.027491553,0.048043344,-0.022046793,0.0017840593,-0.04297627,0.021712622,0.04605025,0.01611981,0.030781247,0.05790378,0.036765575,0.037375722,0.021043088,0.06711892,0.031428516,0.0696344,0.074503615,0.0014903746,0.0033618861,-0.015239198,-0.07063991,-0.045062844,-0.005651632,0.083218485,0.011057021,-0.00672352,-0.042447213,0.010724252,0.017176813,0.0439566,-0.011524096,-0.035661247,-0.055186104,0.03259065,-0.023618732,-0.059643503,0.008956832,0.022796234,0.010824424,-0.00024691786,0.0051432354,0.026598977,0.060586073,-0.083797015,-0.061641812,0.07487727,-0.010346765,0.031396348,0.017735666,0.046781834,0.0051030754,-0.0075569213,-0.08255567,3.187456e-34,-0.021925997,0.10015948,0.043469343,-0.11250568,0.053163297,-0.03806784,-0.09358339,-0.031569365,0.0016574194,0.02231539,-0.036781117,-0.10360432,0.058971446,-0.0054791886,0.010325086,0.019278904,0.010492747,0.013297107,0.039097983,-0.0115604205,0.0018359269,0.0151257645,-0.069941126,0.04709699,-0.010389156,0.034075193,-0.028875565,0.053861823,0.001974697,-0.04023134,-0.013656489,-0.09168003,-0.07996799,0.04965015,0.028300203,-0.06404055,-0.039338887,-0.050957866,-0.007135912,0.016224429,-0.0219446,0.0103121875,0.0026025693,0.03142164,0.041796885,0.004730811,-0.0562631,0.14776056,0.03605939,0.06471164,0.027193863,0.0047693336,0.14590813,0.03735438,-0.047445145,0.028936742,-0.019472068,0.0011432254,0.05868068,0.07131116,0.025882756,-0.053500336,0.043354042,-0.00085147214,0.01500728,-0.004396153,-0.002187342,-0.00012675786,0.010084974,0.04548881,-0.046730146,-0.04207876,0.02785179,0.047327965,-0.03362164,0.03097224,-0.11043661,-0.03679854,0.017002365,0.034662224,-0.05742201,-0.0065172734,-0.023797037,-0.028112084,-0.059468385,0.028692836,-0.029104624,-0.06908821,0.02513767,0.07386091,-0.03269536,-0.11136593,-0.10459524,0.04365725,0.03910894,-2.6382687e-33,0.12701629,-0.038017932,0.046632547,-0.06546509,-0.092287116,0.104679756,-0.016587147,0.008513691,-0.063602984,0.02028308,0.03538268,-0.01895384,-0.019962253,-0.010278185,-0.018231643,-0.06529559,0.057891004,0.08691337,0.029990245,0.048389267,-0.023666307,0.10460865,-0.03689528,-0.03426562,0.017972115,-0.021071529,0.0005053086,0.03863323,-0.004996971,0.060157165,0.015010475,-0.025954401,-0.036964435,-0.036549345,-0.0089094825,0.119198814,-0.012888929,0.015817968,0.08502305,0.03818357,0.05707771,0.044436127,-0.026072826,0.10077284,0.06733008,0.062028386,-0.038854294,0.03895989,0.01664187,-0.1375093,0.014076676,0.051151685,0.0567566,-0.018084882,0.011926151,0.019118633,-0.0038930331,-0.049189463,-0.010274738,-0.016366519,-0.034635864,-0.08597786,0.022056866,-0.008436199,-0.007953441,0.0121192075,-0.028105555,0.02451097,0.05163986,0.00012604891,-0.013053796,-0.015678292,-0.024496857,0.1083147,-0.06194807,-0.036200535,-0.019871734,-0.018098457,-0.00039452527,-0.03508969,-0.015654365,-0.03061232,0.031830925,-0.07692681,-0.005770876,-0.002732321,0.035649993,0.0781626,-0.00045236075,0.024588047,-0.010151837,0.023530882,-0.005100467,0.060075097,0.034485944,-2.7673662e-08,0.071291484,-0.030685741,0.08656271,-0.070291325,0.018985102,-0.03214287,-0.056132596,-0.020024655,-0.012921174,0.010398282,-0.068486705,-0.0068661636,0.03109798,0.045313887,-0.022792112,0.035535686,-0.05207496,-0.04378711,0.0022718264,-0.027560085,-0.1013167,-0.024334438,-0.10512611,0.018687561,0.07382446,-0.07299848,0.03573548,-0.028407412,-0.015664613,0.06497136,0.025709638,-0.01884996,0.00384684,-0.016842572,-0.029629752,-0.012391434,-0.0514193,-0.09521453,0.06933095,-0.059045635,-0.006331966,-0.030969476,-0.06315801,0.031326346,-0.03423256,0.050973628,-0.04194344,-0.047503863,-0.060097363,-0.08563332,0.12439499,0.021777935,-0.03438186,-0.026249543,-0.06485928,0.045850877,0.03735514,0.0030583446,-0.02429065,0.0028162182,-0.019589422,-0.019292893,0.15023516,-0.115591794 +3.1.3.91,"The enzyme also has low activity with N7-methyl-GDP, producing N7-methyl-GMP. Does not accept AMP or GMP, and has low activity with UMP.",384,1.0,0.01836513,-0.08290516,-0.0021458056,-0.0071831136,0.0052683563,-0.031937554,-0.066864274,0.029650448,-0.052717637,-0.04453362,0.012347285,-0.031193849,-0.081766054,0.05830206,-0.009810693,0.06223828,0.051819254,-0.05138147,0.0016393631,-0.031284902,0.065247476,0.00087981025,0.021434817,-0.025119007,0.03977768,-0.022857651,0.045438625,-0.003324955,0.010561896,-0.08207328,-0.043812998,-0.0053286534,0.050240397,-0.030446313,0.0499041,0.12552087,0.0016527607,-0.019656584,-0.05934897,0.011703532,0.075097516,0.015058368,-0.030676747,-0.008962237,-0.054359913,-0.042601887,-0.0073976344,-0.070943445,0.00427688,-0.019109137,-0.07191859,-0.07365517,0.006033744,-0.038105786,-0.04847866,-0.018840814,-0.10889587,-0.026685745,-0.050743703,-0.010771316,0.0067302855,-0.040921636,-0.009008767,-0.04040926,0.08143597,-0.040721975,0.053794388,-0.068271235,-0.056879636,-0.00883337,0.0018570425,-0.09852806,-0.025333159,0.051064167,-0.0019812712,-0.026002977,0.0045582433,-0.017752754,0.112081975,-0.043282665,0.0077703195,0.03659191,-0.066078976,0.05151857,0.019083917,0.007957815,-0.00747425,0.06396796,-0.025577651,0.034977064,0.035887055,0.05016127,-0.0004301333,-0.004154331,0.028069556,0.027943283,0.0013598776,0.039281346,-0.06900397,0.0018522138,0.0041671405,0.11794458,-0.066427365,-0.042385038,-0.06363783,0.0141355125,0.01882412,0.072494075,-0.008218962,0.032051995,0.04637964,0.04157698,0.06285893,0.034849674,-0.035989035,0.07170155,-0.032213327,-0.08431352,-0.08301871,0.057475794,-0.033460688,-0.06772322,0.034897793,0.10317111,-0.061503954,0.09437407,-0.06774691,-4.7685595e-34,0.06708859,-0.06265113,0.033314377,-0.12284062,0.017315004,0.042194992,-0.098920256,0.045587786,0.0038382288,-0.025385456,-0.049597528,-0.071503945,0.037564605,0.013588357,-0.025906904,-0.004107473,0.04034011,0.008309854,0.10787749,-0.003174528,0.025956437,0.031607274,-0.06744895,0.0061028744,-0.02426818,0.10958298,-0.0382453,0.043138936,0.03336621,-0.025937924,0.013053024,-0.09937863,-0.030204732,0.017368047,-0.008643294,0.035201147,-0.023018349,-0.0070790015,-0.01886308,0.0382894,-0.02065373,0.099261,0.029016301,-0.03200585,0.0562529,-0.058405966,-0.009535214,0.03917289,-0.0022524132,0.12370665,0.048039105,-0.0065554995,-0.0020560715,-0.05994792,-0.03356935,0.037375215,-0.01564122,0.037298772,-0.0026917898,0.005808011,0.011317959,0.056733273,-0.020539474,-0.001107068,-0.0054767407,0.01368928,-0.09774859,-0.030308299,-0.009669462,0.08993229,-0.008349451,0.0061154594,0.0705743,0.018139077,0.072619595,-0.06791096,-0.01661601,0.028344033,0.07337976,0.015825985,-0.00096307014,-0.0325108,-0.022065235,-0.046907675,-0.09059602,0.028994862,0.00051558367,0.031885292,-0.018756952,0.02460249,0.030364493,-0.021379711,-0.08352555,0.060650427,0.017943045,-2.5976449e-33,0.053886447,-0.057428062,0.030759754,-0.035585403,-0.0154240485,0.08271962,0.05542849,-0.024784867,-0.008328963,-0.055647433,0.13795672,-0.039524917,0.009012243,-0.037596755,0.09464739,0.027134292,-0.062172692,0.093665205,0.041398805,0.03475205,-0.06725396,0.13049988,-0.03316993,0.12776998,0.023095477,0.003094413,-0.05413609,0.041899305,0.06990005,0.04618224,0.029792776,0.04120046,-0.10248863,-0.04170484,-0.016187511,-0.0011607356,-0.09508348,-0.004601331,-0.037410803,-0.018319378,0.017675657,0.06874812,-0.008581964,0.049837526,-0.025335241,0.0851963,-0.031134633,-0.038029104,0.02954897,-0.040405575,0.03209418,-0.045356687,-0.029460385,-0.0023543225,-0.008564805,0.102502376,0.015669785,0.04220342,-0.031472728,-0.043717958,-0.02553549,-0.062889606,-0.016161598,-0.037338726,0.014038667,0.088588305,-0.029516675,0.044894617,0.06207519,-0.02169745,0.0015526585,0.0047276854,0.0599456,-0.027567927,-0.035021193,0.030454542,-0.077368826,-0.00668324,-0.0045949267,-0.07126586,0.014552609,0.09599632,-0.040692538,-0.059942946,-0.0054703276,-0.0036259838,0.006520505,0.054729845,0.049081963,0.108492516,-0.056231573,-0.006991383,-0.06169121,0.037057716,0.022608632,-3.2767502e-08,0.076452374,-0.07635508,0.05278591,-0.05531441,0.015300947,0.03873779,-0.06776152,-0.036203105,0.06999048,0.051368132,-0.017873634,0.038924553,-0.13321371,0.023143236,0.033686213,-0.048139773,-0.024949014,0.060224183,-0.001905681,-0.037461463,-0.14712487,-0.013374022,-0.081358254,0.05808283,0.007463159,-0.056675635,0.023281734,0.08250696,0.011107359,-0.08096785,0.017998382,0.045560837,0.023806095,-0.01779536,-0.08950327,-0.0013141786,0.059058525,-0.01007355,-0.05414507,-0.014575608,-0.022276826,-0.068467356,-0.057524513,-0.030517986,-0.02548697,-0.03713368,0.06288117,-0.024642076,0.011266182,0.050610706,0.08674666,-0.05097602,-0.0320962,-0.08482518,-0.038932808,-0.0219959,-0.028591001,-0.07110021,-0.049838245,-0.084038846,0.06540879,-0.04370321,0.116642,-0.04997288 +3.1.3.92,"The enzyme, found in the bacterium Bacillus subtilis, is involved in a kanosamine biosynthesis pathway.",384,0.99999994,-0.02729766,-0.022195483,-0.06184839,0.012205773,0.024811052,0.02416953,-0.065047905,0.032664005,0.0069655958,0.03166995,0.03054167,-0.101115145,0.019491555,0.028315384,-0.053142134,0.07115413,-0.09423527,-0.039570276,0.03894605,-0.018301627,0.11892132,0.062070917,-0.016791167,0.0029766134,0.003917916,-0.038179964,0.081106775,-0.084021404,-0.030168047,-0.0038196351,-0.06024361,-0.022217998,0.09065535,-0.059815805,0.07364942,0.06895399,0.013293974,-0.0067652646,0.11003196,0.011432555,-0.005398115,0.0021317939,0.0038532976,-0.014734784,-0.0032521011,0.043146096,0.07342482,-0.026454799,0.0029037925,-0.00946868,-0.07250105,0.00053796143,-0.024486408,0.023349497,0.052922368,-0.006189543,-0.028876396,-0.026786651,0.039467953,-0.0020201036,0.06435435,-0.0006553836,0.025939876,-0.034539204,0.0064623435,-0.097371,0.040407386,-0.018202394,-0.0016251762,-0.057689417,0.008335318,-0.05304784,-0.026642581,-0.0032872602,-0.009771776,0.0077775526,-0.00082693796,-0.015678287,-0.0011741617,-0.06683543,0.019944953,0.012488005,0.054183297,0.08189339,0.034944218,0.024201509,0.09950588,-0.077232465,0.06682441,0.06678509,-0.00029652045,-0.11855523,0.0009826629,-0.06470024,-0.07232143,-0.0725055,0.02865412,0.016633768,0.108236596,-0.02249296,-0.009115852,0.02054823,-0.022943515,-0.071385175,-0.07255053,-0.031456865,0.054625727,0.070940636,0.09001296,0.018490799,0.0045811147,0.051736075,0.04293646,0.02119248,-0.010066931,0.085936494,0.06770785,-0.056508522,-0.052407354,0.05845527,0.010854799,-0.01139406,0.013920349,0.08779482,-0.08292334,0.015727298,-0.124030754,-2.9085943e-34,0.025510998,0.008946986,0.036367018,-0.016104067,0.035427425,-0.056893323,-0.08862506,-0.078752995,-0.08249851,-0.093622595,-0.10493665,-0.078537144,0.0126811685,0.07872411,-0.008676523,0.010385979,-0.05556827,-0.020228866,0.04450218,-0.024123847,-0.036123347,0.02741441,-0.080306284,-0.031467456,0.001262254,0.022879869,0.0788474,0.014290074,0.044350814,-0.010539639,0.067483306,-0.049940497,-0.06724617,-0.003832535,0.045500956,-0.016913781,0.010095148,0.0015297749,-0.06887499,0.013383078,0.0069640875,0.051892336,-0.048046324,-0.027508339,0.034327965,-0.07222725,-0.013987979,0.061700553,0.060990613,0.076351225,-0.03385061,0.018245667,0.14881755,-0.043708704,-0.042235926,0.036570005,0.0016144012,-0.07056896,0.039085407,0.034777902,0.009352822,-0.009373347,-0.034525998,0.056443226,0.01488964,0.038602773,-0.03901443,-0.023124525,0.043318022,-0.011480713,-0.09990166,0.014816986,-0.0007565904,-0.008059533,-0.0593365,-0.0073244898,-0.08878396,-0.012365618,-0.06287584,-0.021795236,-0.04415251,-0.03756939,0.013882889,-0.03744132,-0.036670227,0.039923213,-0.04683263,-0.0898926,-0.039236687,0.07634853,0.046011593,-0.10281352,-0.0865107,0.051825568,0.0039886967,-1.1309665e-33,0.10397536,-0.0938513,0.05541853,-0.09432467,-0.040378384,0.00584634,0.046146292,-0.042512987,0.0289641,-0.0072555537,-0.012932718,0.013394517,0.033612516,0.0040518846,0.027925747,0.026350854,0.04840904,0.066319056,0.035133433,-0.007360951,-0.016779661,0.10000862,-0.03720354,-0.0545931,-0.010295141,0.07053627,-0.038018584,0.14029658,0.005819934,-0.014948109,-0.05317303,-0.014290167,-0.015100769,-0.03722363,-0.055573266,0.011521654,-0.019203365,0.0026215557,0.056947272,-0.012653973,0.010441805,0.09166647,-0.028397582,0.03818126,0.01751461,0.042553257,9.786936e-05,0.05054442,0.021361612,-0.07889222,0.004988658,-0.03817568,0.054102838,-0.06006561,0.04497317,0.028797725,-0.063620776,0.057844553,-0.023659421,-0.065065995,0.00039246108,-0.006090996,0.091006964,0.0077059492,0.027480165,0.11437043,-0.00059325184,0.037006583,0.03305984,-0.08668139,0.036277033,0.05888152,0.03271168,0.054820314,-0.05187122,-0.08111227,-0.12343358,-0.0628357,-0.0073780725,-0.032652956,-0.0064753434,-0.040569235,0.005819266,-0.08157473,-0.036820352,0.019316196,0.0287911,0.0924638,0.025475224,-0.00836919,-0.049562164,-0.029628336,-7.574473e-05,0.07152725,0.059779644,-2.7442427e-08,0.05219195,-0.08300468,0.008953387,-0.024564598,-0.020251174,0.024927897,0.0047104396,0.025462002,0.035099436,-0.057041965,-0.0056868875,0.0747247,0.030607762,0.01237728,0.04245589,0.009596095,0.00065492425,-0.019261079,-0.03162942,-0.024059841,-0.07820832,0.012504054,-0.049831852,0.11003728,0.02655558,-0.04755469,-0.0021692885,0.054826528,-0.011464757,-0.08945968,-0.03092548,0.06836542,-0.032868713,-0.03305145,-0.06762433,0.033686105,-0.093872644,0.0011136507,0.017818477,0.033052593,0.09873048,-0.00045963016,-0.03034634,0.026185226,0.019241858,0.0774441,-0.027889447,0.027552472,-0.020054078,-0.058191847,0.021325784,0.031881083,-0.004934672,0.048075404,-0.09727067,0.028488819,-0.040177338,-0.04568681,-0.033105176,0.00673364,0.0004980171,0.033757437,0.17813514,-0.075868 +3.2.1.186,"The enzyme has been characterized from the plants Cheilocostus speciosus and Solanum torvum. It also hydrolyses the 26-beta-D-glucose group from related steroid glucosides such as protogracillin, torvoside A and torvoside H.",384,1.0,-0.06903496,-0.00022249944,-0.14327046,-0.026615717,-0.0067664683,0.024173196,-0.06399629,0.03559912,0.012940238,0.022812076,0.03652038,0.003955504,-0.07867768,-0.009613606,-0.047950383,-0.034556556,-0.057360217,0.050272733,0.03596054,-0.069794215,0.08983993,0.021219645,0.045505628,-0.01593329,0.05700028,-0.01913379,0.05015476,0.034341767,-0.02750808,-0.059104584,-9.5457224e-05,-0.036791533,0.019681305,0.04428941,0.031770915,0.068268545,-0.08258734,-0.07483478,0.061673105,0.02530234,0.07081852,-0.04253521,-0.04510296,0.030406937,-0.0057509798,-0.043760687,-0.05577686,0.035875097,0.026101574,0.045544393,-0.024739083,-0.09516413,-0.044376228,0.081918284,-0.014294359,0.0066415183,0.006740592,0.0027150179,0.0056599225,0.02116576,0.05692398,0.056200057,-0.06554293,-0.008888162,-0.06323122,-0.016238308,0.00053861976,-0.013956165,0.04353707,-0.07912529,0.00869383,-0.058316857,0.046378843,0.040032696,-0.10417859,0.02760378,-0.053944442,-0.028946135,-0.039665036,-0.041923136,0.09434772,-0.0032096584,0.029385416,0.09484111,0.0348471,0.017937705,0.05310523,0.038764462,0.07181977,-0.0015134151,0.015304322,-0.005104486,-0.080863744,-0.04073781,-0.026443215,-0.0060190493,0.022018561,-0.053910162,-0.0140336035,-0.0031113627,-0.0048791477,0.0073702065,0.013555301,-0.053283203,-0.0496385,0.10516125,0.029501673,0.04951001,-0.009100755,0.024676727,-0.03479846,0.056139264,-0.011151052,-0.020838987,-0.03428819,0.006450269,0.024093,-0.0449157,-0.008354206,0.061813846,0.025343502,0.004730557,0.021309549,0.0022524707,-0.00050126,0.10106621,-0.09648179,3.1695824e-33,0.052530777,0.0054091807,-0.02458832,-0.01678504,-0.023709463,0.011696116,-0.049685262,0.009780334,-0.07555449,0.019358506,-0.18107755,-0.052421305,-0.012137652,0.0485306,0.00058270164,0.03599725,0.05639418,0.004632198,0.10061696,-0.012335104,-0.02986796,0.03830779,-0.052556504,-0.0416818,0.044786174,0.06092174,-0.03000872,0.03092865,0.07214085,-0.0025106042,0.025072612,-0.0983488,-0.013531466,0.07158031,0.06898982,0.06375524,-0.028946508,-0.01512977,-0.004915809,0.053850934,0.041833773,-0.023988405,0.046091147,-0.03846838,0.032648556,0.025450189,-0.04791293,0.03312703,0.07770451,0.058395486,0.032440726,-0.0038925386,0.02132705,0.03304612,-0.0358501,0.063888,-0.020605667,-0.0031416875,0.012618309,0.062451504,-0.043198697,0.06618297,-0.013441147,-0.023795752,0.049926694,0.052138615,-0.13096772,-0.043128103,-0.03119305,0.040270396,-0.09772851,-0.07985761,0.028765038,0.042001463,0.012244471,0.02202439,0.054459162,-0.029120566,-0.046002593,-0.041777566,-0.0021891724,-0.050852798,-0.008347231,-0.014189379,-0.09628193,0.056206,-0.05221233,-0.060020275,-0.015806703,-0.002216253,0.04026469,-0.031140087,-0.06536223,0.022351824,-0.022579635,-4.872035e-33,0.028126806,-0.025473343,0.04392445,-0.076493904,-0.031802766,0.092343345,-0.030380392,-0.123106994,-0.04158774,0.051481206,0.014105658,0.012904921,-0.028859429,-0.086568914,0.023803564,0.05235931,-0.044594247,0.029052896,0.027884329,-0.009451784,-0.049857564,0.123451434,-0.016935583,-0.014750469,0.07562018,-0.0061508054,0.098755345,0.054792665,0.06900588,0.028017433,0.037162993,-0.05072566,0.0035765865,-0.001979109,0.02267366,0.11736675,-0.030829867,-0.008896157,0.03266055,0.06504721,-0.055280697,-0.011445968,0.04063478,0.024733342,0.10680588,0.006706301,-0.021658586,-0.032605153,-0.043433767,-0.0753915,0.055786323,0.00084137893,0.0017687331,-0.0077596866,0.03461707,0.00485281,-0.014474406,-0.001605721,-0.02166073,-0.061695646,0.091443546,-0.11366185,-0.013566673,-0.002541737,0.034582656,-0.007178825,-0.022225771,-0.056316644,0.0019227987,0.10472444,-0.0059174816,-0.0404555,-0.01021047,0.03443261,-0.042376366,-0.011469781,-0.06807751,-0.029135251,-0.039079554,-0.032128528,0.009934969,0.045862246,-0.003258602,-0.06716931,-0.039381,-0.09912194,0.015474114,0.08115497,0.03781743,0.06601365,-0.005028418,0.026939644,-0.062005855,0.02675664,0.10556945,-3.8659756e-08,0.09643113,-0.031758934,-0.014620007,-0.0041043917,-0.013216553,-0.012194793,0.009247682,-0.032227315,0.078577474,0.0067938087,-0.093860365,0.07917089,0.006789524,0.031260766,0.033069793,0.024393944,-0.029848143,0.0764581,-0.030792244,0.0676928,-0.030166851,0.029754566,-0.158823,-0.0056970427,-0.021958165,-0.12809284,0.040023148,0.04249924,-0.05291719,0.06909327,0.023391094,0.04643107,-0.021141378,-0.10788558,-0.024751348,0.0936669,-0.05518678,-0.007666414,0.021180151,0.022286613,0.014667323,-0.036661353,-0.043265518,0.06098963,-0.06762175,-0.008506456,0.052555546,-0.015898481,-0.035633568,0.028263278,0.03560186,0.016792525,-0.060162324,-0.07620969,-0.09634159,0.02298421,-0.048710663,-0.057887904,-0.049701612,-0.10410843,-0.045287028,0.009590126,0.17081958,-0.03038455 +3.6.3.55,"An ABC-type (ATP-binding cassette-type) ATPase. The enzymes from the archaeon Pyrococcus furiosus, the Gram-positive bacterium Eubacterium acidaminophilum and the Gram-negative bacterium Campylobacter jejuni transport tungsten into the cell for incorporation into tungsten-dependent enzymes. 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+4.1.2.54,The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). 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+4.1.3.44,"This enzyme, which is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters [3,4]. Carbons C2 and C3 from pyruvate are incorporated into 4-demethylwyosine [3]. The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine.",384,1.0,-0.025593564,-0.02851104,-0.1469548,0.057649072,0.0806549,0.017270518,-0.0997481,0.030747533,0.057635438,0.0031405853,0.0047998484,-0.04447056,-0.04477437,0.054900736,-0.030749967,0.068734504,-0.14151974,-0.010108571,0.019385807,-0.053481963,0.03505159,0.05689101,0.051119067,-0.016410466,0.042254366,0.024563119,0.10091068,-0.008406575,-0.010573345,-0.011847405,0.012780584,-0.054463904,0.06321154,-0.024659479,0.05343994,0.14760578,-0.02637309,-0.06623914,0.077973865,-0.0124034975,0.011016776,0.014963437,0.02064712,0.03239565,-0.04787215,0.01691079,-0.006579296,0.053152096,0.012103006,-0.041781347,-0.027800221,-0.09920493,-0.07689991,0.085807145,0.0232514,0.04007944,-0.012694377,-0.0046014125,0.077958874,-0.022538487,0.1148933,-0.014331311,0.035471894,-0.026147965,-0.013964712,-0.018281108,0.07838517,-0.008731922,0.041465584,-0.06800513,-0.06602763,-0.00047528258,-0.0005538544,0.03487302,-0.024454063,0.024885813,0.036055658,-0.054421417,0.063569546,-0.057801414,0.03762868,0.0073748035,0.04597991,0.030427245,0.07577573,0.019281095,-0.045028716,-0.044321783,0.047093876,-0.007066383,-0.03997549,-0.031384576,-0.04225989,-0.06744132,-0.00744546,-0.0117040435,0.08855134,0.045641035,0.031287663,-0.011138388,-0.0062240753,0.040402412,-0.041483898,-0.049873058,-0.047271278,-0.024270512,0.039476745,0.10731267,0.013820821,0.008911945,-0.009286451,0.06890673,0.043537088,-0.009812719,-0.01953404,0.047173653,0.08745197,-0.05046398,-0.074221425,0.031550422,0.013330623,0.015051371,0.0971837,0.02769954,-0.06638475,-0.020040251,-0.12156855,1.7933773e-33,0.10272172,0.037842393,-0.0144114215,0.01835462,0.066631034,-0.030676566,-0.06993057,-0.02844527,-0.07461693,-0.0148054045,-0.13900453,-0.082976975,0.10277794,-0.01889022,-0.053959858,-0.058682878,-0.035941657,0.018400457,0.021500533,-0.0065279277,-0.036677938,0.03665513,-0.0513984,0.00061359676,-0.026408665,0.013169675,-0.010716446,0.054779347,0.074361265,-0.0051155994,-0.060003683,-0.04355604,-0.12110554,-0.056574732,0.050684914,0.014228479,-0.08778776,-0.10348176,-0.0005945928,-0.022527242,-0.0019706592,0.0047067557,0.010429819,-0.07784851,0.06188537,0.005538936,-0.02903144,0.037354216,0.022010934,0.06840473,0.026271915,-0.02704552,0.08869657,-0.024605036,-0.10844441,-0.023455335,-0.005502388,-0.08332348,0.09408748,0.063449666,0.022311004,0.02262575,-0.04251403,0.028186895,-0.023123296,0.035859935,-0.040703543,0.014414983,-0.024581812,0.079188764,0.025302412,-0.05882438,0.07822011,0.022458011,-0.02592281,0.011948348,-0.039192513,0.014746846,-0.032268833,-0.06648781,-0.0046879165,-0.056292713,0.020350842,-0.06575657,0.025756732,0.008770115,-0.061701763,-0.07168933,-0.017282672,0.05661784,-0.02554287,-0.032494858,-0.027313521,0.0321879,-0.01994154,-3.0409855e-33,0.052189842,-0.0181224,0.027557988,-0.103978306,-0.10254407,0.04765417,-0.027350172,-0.07504781,0.007109624,-0.022536907,0.13023965,-0.045856785,0.0077591212,-0.05368536,0.0727456,0.040398024,0.010784076,0.00029318532,0.04700364,0.037912104,0.07707838,-0.005556373,-0.055660844,0.029054862,0.007569129,0.008583277,0.008929002,0.03704733,0.033083156,0.054814376,-0.053821776,-0.0593134,-0.06764375,0.006754416,0.003965441,0.0014709521,-0.0466922,-0.012079882,0.045437947,-0.030768765,0.05668297,0.04984077,-0.033807494,0.13452895,0.01734331,0.06966893,-0.038154196,0.032179154,-0.037267614,-0.04306827,0.026319588,-0.032251816,0.006921473,-0.015153311,-0.0032635028,0.075398706,0.0050740466,0.024247484,0.010672851,-0.0425255,-0.06787403,-0.10444443,0.03856303,0.025154477,0.0652157,0.008872919,-0.06656119,0.047467664,-0.013712,-0.0017738676,0.005331154,0.015085908,0.0029756185,0.04023452,-0.06528594,-0.04099258,-0.012110602,-0.058056854,-0.028696174,-0.028204327,0.0069598937,-0.0013958232,0.05863584,-0.14508738,-0.039628863,-0.09896622,0.08441416,0.10057612,-0.003366458,0.023945073,-0.03854549,0.010603039,-0.0059203953,-0.0033703574,0.09086332,-4.0250164e-08,-0.023429975,0.0021430573,0.038208958,-0.023988131,-0.054246727,-0.0048466013,0.037165467,0.06533426,0.0035056616,-0.005919517,0.002299329,0.06300161,-0.0011200879,-0.02093741,0.0017207784,0.061639387,-0.12452443,0.0135873305,0.022335557,-0.008540265,-0.026052905,-0.023388674,-0.0007888297,0.066797346,0.031019052,-0.045770306,0.041567933,0.0732401,-0.025839211,-0.066719666,0.0071185804,0.039957613,-0.0059504057,-0.008798892,-0.104331866,-0.0073857736,-0.08907462,-0.017959518,-0.063499995,0.0690636,0.02511301,-0.027442547,-0.03289673,0.043099873,-0.039081715,0.058768146,-0.014834905,0.079897895,0.020145033,0.003463587,0.0629647,-0.015315112,0.031438563,-0.022413941,-0.07310387,-0.00884362,-0.05431688,0.02532579,0.006890154,-0.044495158,-0.016084958,-0.0033158907,0.14910693,-0.058376826 +4.2.1.145,A pyridoxal 5'-phosphate protein. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin.,384,1.0,-0.05914056,-0.0072425413,-0.060975414,-0.06841906,0.020191833,-0.027413085,-0.014526965,0.03760209,0.13191035,-0.0014990658,0.04416088,-0.006172342,0.007392683,0.08783744,-0.057007145,-0.026311303,-0.05929043,0.020295493,0.03841961,-0.03235766,0.08323572,0.10165496,0.03625065,-0.018002396,0.021113688,0.05451333,0.01759216,0.10862234,-0.018744512,-0.06115425,-0.00034648154,0.018852418,-0.004064971,-0.09594856,0.07636411,0.06380289,-0.103670456,-0.008757742,0.11266309,0.014319872,0.0014174099,-0.032349296,0.012959574,0.059244085,-0.04640997,0.04061784,0.030517584,0.057313167,0.08147234,0.0065260427,-0.086057425,-0.03165266,-0.035380267,0.03774519,0.0562743,0.035112076,-0.022284774,-0.05439348,-0.027693054,-0.041341085,0.07828763,0.004557492,0.020504488,0.035220433,-0.10835687,-0.028201578,0.0021409479,-0.04737496,-0.0063776392,-0.022268241,-0.08694349,-0.038174096,0.09098939,0.020595875,-0.015740942,0.057947557,-0.06052687,-0.027891103,-0.033913113,-0.008348752,0.06813768,0.0023240126,-0.0104338825,0.14052646,0.058731854,-0.020832479,0.12577508,-0.012772971,0.034576356,0.0023210356,0.0140513955,0.03166857,-0.019620027,-0.044893164,-0.07229026,-0.018713268,-0.05908587,-0.040422443,-0.044992514,1.3969463e-05,-0.014334985,-0.012637076,0.015977018,-0.03128795,-0.065433,0.007606757,-0.01278355,0.07664731,-0.023184542,-0.04215228,-0.07037401,0.038574856,-0.025293408,-0.055976078,-0.020868758,0.053589027,0.026754616,-0.02700438,-0.02675647,0.034364447,0.01366535,-0.013348715,0.0070139663,0.063186355,-0.059398863,0.036235504,-0.07325137,8.358255e-34,-0.024396017,0.09153777,0.03166247,0.019324737,-0.0039956686,0.0014739828,-0.021034919,-0.05623429,-0.094871774,-0.058334813,-0.04092845,-0.1042534,0.0660554,0.056097593,-0.02081164,-0.02896745,-0.04580609,0.046847645,0.022587543,-0.020457674,0.11304617,0.08993704,-0.02452714,0.03886169,0.027033502,0.06871347,-0.03494666,-0.0013752831,0.06279088,-0.024787115,-0.008509961,0.012410732,-0.040003,-0.06849199,0.09382021,-0.062932335,-0.007689441,-0.08416971,0.044552382,0.0701951,-0.012183949,-0.026557699,-0.009550076,-0.0038829753,0.05114115,-0.03347373,-0.06477946,0.09142114,0.010838311,0.01948228,0.06435121,-0.039992694,0.040450457,-0.032544333,-0.12694211,0.007836489,-0.008942668,0.010407721,-0.04452894,0.009678799,0.01009443,-0.0017775204,-0.029553678,-0.02981999,5.7648525e-05,-0.015308499,-0.0047141225,-0.10279948,0.043629155,0.073747076,-0.047884922,0.026817078,0.033224884,0.0056527555,0.026558235,-0.019265454,-0.097312756,-0.02700138,0.019844757,0.042611357,-0.075113714,-0.044227958,0.013645162,-0.089278646,-0.0023390164,-0.06674259,0.0042506605,-0.071062334,0.04008275,0.017273514,0.057445593,-0.093576156,-0.049138673,0.026681442,-0.024794577,-1.9780073e-33,0.07746815,-0.05295719,0.0938168,0.016185623,-0.06652429,0.047009755,-0.01724333,-0.046652034,0.034196693,-0.037625518,0.024734028,-0.010188826,-0.019296322,-0.033535615,-0.013282598,0.0054611047,0.017776858,0.02124923,0.048164528,0.03211526,0.0064610373,-0.0027175134,0.068910874,0.03677256,0.06962967,0.052636232,0.048808154,0.028200652,-0.00021732904,0.06682577,-0.009990541,-0.00750817,-0.018375179,-0.025568059,-0.029980617,0.10250969,-0.057748612,-0.02619929,0.034439366,0.015141094,0.026917638,0.024540938,0.010814297,-0.028483853,-0.06652986,0.002334903,0.012017334,0.090374105,-0.017527947,-0.11508772,0.05081204,0.036282193,0.015172979,0.000731828,-0.017672213,0.020016605,-0.028641166,0.012845574,0.078949496,-0.0023121801,-0.0019718825,-0.037809506,0.044533115,0.05549728,0.015516933,0.059195455,0.016204337,0.038817145,0.07431143,-0.0058207586,0.022773301,0.054795492,0.039195463,0.0329762,-0.003213185,0.03442684,-0.04043338,-0.044226393,0.0088738445,0.008618826,-0.03325345,-0.031660095,-0.060923155,-0.049989343,-0.07842076,0.007966083,0.05825264,0.06301935,0.046647493,0.024647882,-0.011453146,0.01451846,-0.007121103,0.030329427,0.04911172,-2.6580183e-08,0.08755349,-0.03172837,0.02920899,-0.02929056,0.030771134,-0.027322592,0.027032489,-0.033184417,0.09515509,0.041982096,-0.0068545537,0.018113766,0.029165968,-0.024309201,-0.0053114225,0.11266422,-0.052575383,0.033112437,0.0027837553,-0.007146592,-0.06540834,0.020152237,-0.13289769,0.0003859852,0.074794516,-0.040949028,-0.016911164,-0.022608873,-0.041312583,-0.0021707371,0.067007184,-0.016842445,-0.07120271,-0.07135413,-0.07556045,0.05981954,-0.115865886,-0.049696423,-0.015237585,0.0057280012,0.033303227,-0.037030663,-0.04646126,-0.029580016,-0.07435236,0.064090684,-0.05187761,-0.033488154,-0.06993386,-0.027813146,0.03911784,0.03838256,-0.06307329,-0.005357696,-0.14473538,0.02779634,0.061132964,-0.0412252,-0.044714794,-0.12390974,-0.13218695,-0.030965824,0.19303092,-0.030112717 +4.2.1.146,The enzyme takes part in a D-galacturonate degradation pathway in the fungi Trichoderma reesei (Hypocrea jecorina) and Aspergillus niger.,384,0.99999994,-0.011172947,-0.04862383,-0.048011493,-0.05293455,0.031719442,-0.019296521,-0.051654153,-0.00046798273,0.0028053753,0.046331156,0.026065608,-0.0012025323,-0.05408261,0.025314957,-0.11741806,0.009033331,-0.01181949,0.033387475,0.037807465,-0.0061696186,0.12370621,0.052530024,0.020134972,0.044399526,0.03205447,-0.03425882,0.06833505,-0.06736384,-0.12444284,-0.08846627,-0.00611366,-0.026929708,-0.0226633,0.0026612177,0.012311607,0.08723413,-0.025995092,-0.040339235,0.10107618,0.03043015,-0.031302404,-0.0041886475,0.0036040375,-0.054102592,-0.03444772,0.0142059345,-0.0950611,0.03159901,0.03285036,-0.029214121,-0.024141913,-0.021384075,-0.011965397,-0.023602627,0.07533573,0.1263576,0.02466572,-0.063991405,-0.019356493,0.10338349,0.0650118,0.029776428,0.027123414,-0.029100785,0.008706952,-0.059828203,0.045069188,-0.021277154,-0.0012565952,0.0001682074,-0.013977247,-0.056118805,-0.054137476,-0.06446432,0.036093414,0.011788254,0.024059286,-0.05120898,0.07602527,-0.0927368,0.061289486,0.05061097,0.11471779,-0.0018263541,-0.0321924,-0.06515537,0.058862463,0.01595181,0.020830546,0.0055816094,0.07494817,-0.012107593,-0.039707277,0.016660327,-0.069583625,-0.016061787,0.02217975,0.016689885,0.009480405,-0.06412741,-0.010991494,-0.050856307,0.048734795,-0.0674824,0.014563081,0.042153273,0.019206861,0.081349745,0.14669041,0.04513604,0.022409996,0.026658123,0.011336199,0.030854385,-0.04238957,0.07183708,0.036768977,0.0082617365,-0.0593494,0.0141310925,0.01504072,-0.0019086568,0.010974219,-0.011342983,-0.017519217,0.055076215,-0.01308919,2.2864956e-33,0.051591434,0.00123363,-0.0686175,-0.027745757,-0.04238844,0.00055560266,-0.049589697,-0.0050783814,0.0018080147,-0.09251067,-0.045923408,-0.07342317,-0.09589919,0.08198815,-0.027970357,0.057877954,0.01356884,-0.047157697,-0.01070448,-0.010920432,-0.028275479,0.07548543,-0.106593415,0.016110534,0.1078675,0.07006403,0.0057798787,0.05110193,0.062014796,-0.010384291,0.04461943,-0.063926384,-0.07989811,0.0141880745,0.12616348,0.046863712,0.036479957,0.009794945,-0.021981945,-0.04410157,-0.024338827,-0.0064478945,-0.007349682,-0.06910391,-0.00805482,-0.032247014,0.006057814,0.08957849,0.025173768,-0.00012900148,0.029089706,-0.005351553,0.035559453,0.08696282,-0.05659077,0.03644663,-0.046134833,-0.02557962,0.10294857,0.012578569,0.00011782197,0.034158107,-0.029736366,0.077593446,0.045138814,0.01379719,-0.047700882,-0.0434248,0.024889832,0.025924744,-0.0660266,-0.058992453,0.0024091506,0.0058177207,-0.060868494,-0.049560983,-0.030740784,-0.024066268,-0.0064380704,-0.029139439,0.020565353,0.002094322,0.02128765,-0.014000823,-0.026675038,0.027763473,-0.004286124,-0.013814244,0.0070196628,0.02321103,-0.004307004,-0.002615063,-0.0263585,0.021706138,0.027306687,-3.8166626e-33,0.09273811,-0.048925646,0.05385776,0.048555367,-0.07410878,0.09893508,-0.023283387,0.040528707,-0.006112266,-0.14838523,-0.011221368,-0.0058798664,-0.008780361,-0.0594221,0.047554698,0.012841789,-0.029381458,0.111294076,-0.06752392,-0.013934989,0.0063234847,0.09729021,-0.06264214,0.0004050088,0.010419703,-0.027220061,-0.050188623,0.04969967,0.0073280297,0.006949394,0.027989613,0.006489673,-0.013244639,-0.01688119,-0.06341281,0.05768041,-0.019987948,-0.012478747,-0.031037718,0.042502064,0.007765118,0.0027573197,-0.0011393956,0.042062458,0.047277283,0.079192534,-0.05276496,0.055926662,0.023598636,-0.0060105175,0.020008111,-0.07307824,-0.018405035,-0.0126686795,-0.014336043,-0.0055694687,0.07276231,-0.028287625,0.0013514425,-0.015642146,-0.068122864,-0.017898768,0.056530476,-0.036578983,0.047095027,0.015486491,0.0028571433,0.059228823,0.099115536,-0.061584696,0.113284126,0.072631426,0.011054811,0.038648274,-0.031715043,-0.0127795525,-0.1331518,0.022411058,0.018874314,0.0006183632,0.108708434,0.02166269,0.06293644,0.002307433,-0.030853238,-0.042126976,0.087970726,0.100908674,-0.06553657,-0.006465685,-0.038467076,-0.048126582,-0.041403733,0.0150392195,0.013585297,-2.9034535e-08,0.09852658,0.042490374,0.016401524,-0.1301859,0.017273476,-0.014126435,0.09411514,0.085941404,0.055052374,-0.007162996,-0.04813776,0.07336974,-0.09030733,0.04301376,-0.0033221901,-0.0011593893,-0.031528793,0.06467797,-0.026836697,0.06050585,-0.067464605,-0.0372387,-0.11418576,0.04452688,-0.05944014,-0.019069798,0.09489894,0.059064064,-0.009556204,-0.014620609,0.0040724613,0.064044155,0.0047098114,-0.022645367,-0.09375467,0.022559306,-0.037333768,-0.015731351,0.041066542,0.061533026,-0.037575874,-0.017224541,-0.011928793,-0.044266004,-0.08736176,-0.09475564,0.0052756965,0.008123658,-0.036935132,0.054635443,-0.049535222,-0.015557875,-0.07877433,-0.056040812,-0.08380912,-0.07236578,0.024194285,-0.02696857,-0.05987207,-0.11021963,0.037976008,-0.08193039,0.088089004,-0.028539559 +4.2.3.144,"The enzyme is a component of the herbivore-induced indirect defense system. The product, (E,E)-geranyllinalool, is a precursor to the volatile compound 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT), which is released by many plants in response to damage.",384,1.0,-0.030118056,0.046349343,0.0035879181,-0.014249862,0.06321963,0.072724566,0.042316288,0.108225636,0.08135627,0.04793863,0.11084935,-0.050396167,-0.028137112,3.5247605e-05,-0.034894682,0.008754497,0.026239313,-0.018026426,-0.0003648654,-0.09372438,0.016224911,0.06740898,-0.0022232258,0.016025288,-0.0036124291,-0.041949492,-0.008032098,-0.009698494,0.042873405,-0.06414098,0.030656142,-0.01748178,-0.008871223,-0.029905992,-0.08846744,0.04708727,-0.049579404,-0.09583957,0.03993733,0.044818833,-0.0013758498,-0.041214343,-0.05744743,-0.02730306,-0.09954822,-0.033704963,-0.0024264713,-0.01728858,-0.01825103,-0.073139444,0.020307643,-0.031243112,-0.03124842,0.009874269,0.041137654,-0.037679814,0.033320624,0.023139594,-0.032170545,0.04386469,0.13948326,-0.0135792885,-0.04579701,0.0024225642,0.019391496,-0.0033938678,0.052366786,0.03570824,0.039296936,-0.04632383,-0.012375894,-0.105284594,-0.048617,-3.8457445e-05,-0.061351415,0.071726695,0.007904643,-0.026666246,0.043616224,-0.011430322,0.047851823,0.09045579,0.031088388,0.027399618,0.06587487,0.013329694,-0.0525797,0.09160435,0.07889201,0.0074676,0.05611735,-0.037825454,-0.009879011,0.050149567,-0.030980596,0.0531452,-0.009947259,-0.076050505,-0.01676719,-0.0051417383,0.018203305,0.030530814,-0.111183204,-0.019490624,-0.07247181,0.014736214,0.03770114,-0.031159248,0.062187463,0.0151235685,-0.09734489,-0.008763775,-0.016334629,0.011047698,-0.09077828,0.05754972,0.006602523,-0.041886996,0.0696337,-0.017291132,0.08551679,0.001310616,-0.0047689504,0.08087796,0.04676302,-0.018488506,-0.07153155,-3.08321e-33,0.06807636,0.020284811,-0.089099795,0.03518532,-0.010545948,0.015991937,-0.05032325,0.016222946,-0.03992474,-0.039855063,-0.076051876,-0.12960424,0.010276479,0.08319751,-0.032266606,0.0018712623,-0.02880315,0.007862784,0.07647421,-0.08023279,-0.069921255,0.06537148,-0.06235363,-0.007852824,-0.0051804795,0.038532447,-0.05013174,0.023106473,-0.0050157993,0.017747832,0.008680539,-0.11680904,-0.06626978,0.056240905,0.060339052,0.015363142,-0.073302016,-0.014543634,0.0035623782,-0.0062869736,0.011879215,0.06111995,0.042883635,0.006610323,0.06297683,-0.044375353,-0.096320786,0.05604551,0.05175294,0.011507663,0.06300325,-0.017854655,0.08697304,-0.028088832,-0.092952795,0.10557371,-0.019338943,0.0030345768,0.015139129,0.0063889213,-0.032769453,0.08427914,-0.036786277,-0.013052615,0.034004733,0.009993058,-0.06348647,-0.07783301,0.035547588,0.07754833,-0.024026167,-0.04059562,0.06619479,-0.015103689,-0.014274471,-0.020181248,-0.012083885,-0.0060684946,-0.0026721978,0.009923531,-0.040217485,-0.08167855,0.021867903,0.0004978319,-0.06067424,-0.02907397,-0.05439814,-0.02417913,0.024421396,0.06565595,0.09408818,-0.04481272,-0.04634729,0.077911064,-0.010036341,1.4465811e-33,0.024078943,0.010878452,0.027458448,-0.05383446,-0.06594304,0.07780867,-0.025199097,-0.013953183,-0.017347198,0.06710767,0.05528053,0.010686702,0.006099958,-0.06842275,0.07513207,-0.015687175,0.016202724,0.05268307,0.0023537993,-0.09060041,-0.07593495,0.008127783,0.006170042,0.019482011,0.024321783,0.048357923,0.04850738,0.0238352,-0.0005059177,-0.0025916256,0.013623306,-0.07784268,-0.022062536,0.04311593,-0.0047024586,0.034276765,0.0012698701,-0.03213427,-0.036859322,-0.039135836,0.017263591,0.049095124,0.08976147,0.01545492,-0.021853276,0.07725771,-0.009746328,-0.008028345,0.03193835,-0.01383483,0.102605745,0.027139561,0.019716498,0.012439977,0.01392596,-0.010701413,0.08380795,-0.03433081,0.010514376,-0.030067615,0.015750427,0.034107037,-0.011707455,0.0064769825,0.018473059,-0.0075434106,-0.084518135,0.05821838,0.07773709,0.013762805,0.05474688,0.09775108,-0.041982677,-0.046580955,-0.107567325,-0.0501778,-0.06345723,-0.09309204,-0.009943622,-0.057325862,-0.0061016614,-0.0022174355,-0.005047151,-0.089040555,-0.026021635,-0.10902636,-0.047930118,0.16791262,0.09473611,0.020034127,-0.009128915,0.031292,-0.06574541,0.058006275,0.11591294,-4.1550166e-08,0.017714871,-0.087583855,-0.020050889,-0.029915385,-0.036459044,-0.03478902,0.028400188,0.016521597,0.046840813,0.0027112456,0.008635356,0.055984333,-0.013947515,0.0584857,0.024540903,-0.053960588,-0.030314784,-0.029914387,-0.044137765,-0.022521215,-0.050005715,-0.020858718,-0.046210866,-0.023078015,0.007558281,-0.04873219,0.025322704,0.11300522,0.09083595,-0.017820919,-0.0069318893,0.047531284,-0.09150358,-0.0022275592,-0.13751152,0.10292482,0.019030724,-0.049757708,-0.0275661,0.043733887,-0.043886106,-0.033829466,-0.04577514,0.020388698,-0.014788582,-0.022730285,-0.0017034156,0.018482232,0.016811626,-0.06559368,0.023441778,0.024221027,-0.03032185,0.0073886313,-0.07848044,-0.06928338,-0.013750958,-0.051189356,0.074907385,-0.09405313,0.047158115,-0.011821781,0.15261462,0.015557299 +4.4.1.27,"The enzyme contains Zn2+. The hyperthermophilic archaeon Acidianus sp. A1-3 obtains energy by the conversion of carbon disulfide to hydrogen sulfide, with carbonyl sulfide as an intermediate. 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+5.1.3.26,The enzyme is involved in biosynthesis of the repeating tetrasaccharide unit of the O-antigen produced by some Gram-negative bacteria.,384,0.99999994,-0.06298166,-0.03749021,-0.13947426,-0.014932599,-0.031036844,0.030884778,-0.034273665,0.060745377,0.11724221,-0.017750377,0.060385533,-0.062277928,-0.00901274,-0.0004948121,-0.08465515,-0.018158717,0.014776644,0.021269308,0.012630661,-0.11401628,0.090507105,0.015315893,-0.03347285,-0.02417304,0.024981353,-0.028930569,-0.016914817,-0.0059836307,0.0430786,-0.043053236,-0.008757678,-0.060845863,0.0368103,-0.09807656,0.044745296,0.024407035,0.018681882,-0.02716247,0.05896425,0.0034801206,0.012922361,-0.02345952,-0.02927723,-0.04349049,-0.05299607,-0.011922599,0.015984403,0.059957843,0.01533937,-0.020413151,-0.027769076,-0.037872314,-0.081550606,0.040521584,0.035438746,-0.015008934,-0.013208065,-0.027261678,-0.029317707,0.022066405,0.020668129,-0.009699843,0.03204739,0.057581574,0.012414748,-0.09535925,0.01821267,-0.040114757,-0.056602065,0.0012166452,-0.06200049,-0.019460117,0.04008263,0.055211626,-0.003898527,0.05348563,0.01757523,-0.0038961584,0.054844905,0.06985292,0.08511652,0.0063385987,-0.03286561,0.10947129,-0.010848006,-0.08822245,0.002910137,0.006591513,0.086143956,0.017155183,0.0095814755,-0.037482813,0.026246546,-0.053661283,-0.042358465,-0.037223976,0.025980772,0.027871573,0.0706513,-0.04370755,-0.070451796,-0.012824063,0.0572695,-0.075898625,-0.095905155,0.009902944,-0.055410717,0.07459506,0.100872606,0.03405441,0.015108772,-0.0058688615,0.0074973824,-0.022338023,-0.08259199,0.075986534,0.029826019,-0.0923132,-0.026777275,0.013941053,0.007637668,-0.027979566,0.039916195,0.10712651,0.032640543,0.06421916,-0.016951043,-2.226765e-33,0.0724618,0.025599193,0.0068134107,-0.04418186,0.014635228,-0.015720267,-0.019094424,-0.020438524,-0.0207659,0.019887194,-0.044334065,-0.11644196,0.043323502,0.07492358,0.016490629,0.028522545,-0.030582702,-0.07336328,-0.036382526,0.04327406,-0.044196952,0.0946923,-0.010055387,0.011728747,0.03872138,0.083765306,-0.07599364,0.0060893935,0.005014998,0.0063545527,0.08440572,-0.048264593,-0.15462181,-0.0006141433,0.16377534,-0.02189147,-0.010322391,-0.010123084,0.029859493,0.019002289,0.0241566,0.037536435,0.020127816,-0.06368057,0.07836001,-0.02808109,0.017380793,0.031125866,0.041446332,0.06848461,0.08572062,-0.0034498388,0.009995997,0.0018777391,-0.10024415,0.024611048,-0.07600156,0.036289327,0.026173722,0.06427249,-0.047778994,0.013140329,-0.009700387,-0.0031997277,-0.049000584,-0.015445579,-0.023192031,-0.045359645,0.034754075,0.05588149,-0.002751547,-0.05344481,-0.0042471923,-0.02908741,0.016898558,-0.033684816,0.020624753,0.0064632283,0.05351966,-0.05573759,-0.004520414,0.01518725,0.023942675,-0.03956191,-0.078423046,0.013274752,-0.03167888,0.0013567221,-0.040079653,0.032590184,0.06405782,-0.047671,-0.09349007,0.06530948,-0.0071809413,-1.3852083e-33,0.09269804,-0.11611991,0.05583327,-0.091579296,-0.090439275,0.040055614,-0.030546451,0.040801525,-0.030666918,0.021840475,0.06638209,-0.00402831,-0.002441887,0.01565227,-0.015560833,-0.005330613,-0.022242999,0.11048261,-0.054428544,-0.01567747,0.016235128,0.04749614,0.069036484,-0.07650129,0.03243687,0.037011623,-0.02211182,0.0820555,0.033482153,0.0017911715,0.009352337,-0.04975467,-0.012416016,-0.02240322,-0.046302866,-0.009261583,0.015232616,-0.019858317,0.07834935,0.02622622,0.030927747,0.037966654,0.049168225,0.024223208,-0.010292418,0.0374499,-0.03132175,0.04768448,-0.022382608,-0.07307201,0.0428784,-0.026459128,0.019409183,0.0110048745,-0.023722978,0.029144973,0.028033761,-0.022118676,-0.016358588,-0.047082316,-0.012568874,-0.060846727,0.07606431,-0.037305925,0.042462584,0.0801587,0.020929836,0.013082556,0.061377306,-0.026188856,-0.001882412,0.0453894,-0.06704597,-0.05613396,0.0050334334,-0.04515343,-0.14603926,-0.039992988,0.03253714,-0.017364865,-0.09758385,-0.025056055,0.0152185345,-0.02380405,0.023836182,-0.051021807,0.009748835,0.15064304,0.07806825,0.08709345,-0.04066767,0.02567114,-0.005908685,0.0881087,0.10771126,-3.0286344e-08,0.031265277,-0.10589139,0.0033775088,-0.010188302,-0.02610483,0.016523296,-0.028319972,-0.047845185,0.013649274,0.021777421,0.037255142,0.08301038,-0.060655117,-0.011848184,0.04038235,0.05559735,-0.071551666,-0.0452517,-0.023024803,0.0023030941,-0.046538208,-0.015640829,-0.09069258,0.077540085,-0.009966253,-0.0103815785,-0.0018201021,0.040993053,-0.030872341,-0.061550457,-0.024845887,0.06223543,-0.07270491,-0.0732432,-0.15488628,-6.3763815e-05,-0.021841194,-0.06098586,0.0025541582,-0.013082296,0.01748301,0.019494416,-0.02410739,-9.696257e-05,0.0034180204,0.062422357,-0.03842291,0.025830768,-0.06466136,-0.028837824,-0.030991795,-0.04433706,-0.06501379,0.015629796,-0.115435965,-0.089050084,-0.03782048,-0.043163426,0.008060046,-0.013934706,0.0241498,0.04473237,0.16108622,-0.05332391 +5.3.1.29,This archaeal enzyme is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The enzyme is activated by cAMP [2].,384,0.99999994,-0.08485094,-0.06292476,-0.124561235,0.002092454,0.03915342,-0.010068084,-0.03891798,-0.030050114,-0.02528846,0.024650265,-0.022532336,-0.0353312,-0.067360565,0.046680007,-0.010906566,0.026933758,-0.0011506496,-0.00092106423,0.0279517,-0.041618876,0.09246747,0.04938368,-0.00016085901,-0.0039893733,-0.0152308345,-0.021588434,0.0050849435,-0.03757672,-0.064057045,-0.056001954,-0.013929244,-0.008069865,0.013749588,-0.08862256,0.031782817,0.115703955,-0.07169382,-0.054079782,0.054157782,0.0309484,0.019650036,0.004459123,0.0667658,-0.05620374,-0.036378328,0.0069047273,0.010826013,0.028363448,0.08413928,-0.07627859,-0.032565877,-0.06664377,-0.07588718,-0.0035992665,0.007837683,0.04692356,-0.04893173,0.0043548183,0.0274758,-0.0196422,0.089529976,-0.005824981,0.028765302,-0.0086751105,0.036431313,-0.03689566,0.031068696,-0.08895592,0.030896377,-0.0773483,-0.05085145,-0.061568696,-0.041067317,-0.011756428,0.02196403,0.024590515,-0.0037074338,-0.030478649,0.077564366,-0.042570353,-0.016136028,-0.0056285486,0.003395999,0.022726532,-0.011594931,0.02354573,0.10182003,0.0016869688,0.03150589,0.072409056,-0.0077282097,-0.006179904,0.025960844,-0.056300938,-0.060472,-0.010348509,0.047925707,0.079470895,0.009796842,-0.029800914,0.042943384,0.062299877,-0.02043741,-0.13563992,-0.06418881,-0.052261606,0.031423226,0.19380489,0.05252293,0.023059398,0.018503113,0.06590955,0.048173923,0.011734155,-0.0072742044,0.17441308,0.05622366,-0.063097924,-0.064285204,0.060404107,0.040196642,-0.0520103,0.02314592,0.03197432,-0.051775027,0.023485865,-0.051982816,6.968242e-34,0.043737207,-0.028245911,-0.0073670703,0.005419128,-0.006546349,0.00932553,-0.16241245,-0.06532008,-0.015415523,-0.040294066,-0.058774218,-0.021559222,0.08781341,0.07325921,-0.117563166,-0.045893118,-0.015680157,-0.0067616035,0.063631095,-0.021615155,0.041122224,0.058018856,-0.015345397,0.015892938,0.039253335,0.06826116,0.05642761,0.022794137,0.02608983,-0.0021091113,0.06648831,-0.09749833,-0.12148866,-0.01869926,0.05051136,-0.038748953,0.011716279,-0.053870477,-0.050084386,0.009259651,0.010187649,0.09255177,0.0063560354,0.007666765,0.011438138,-0.063725404,0.0060539306,0.12980329,0.06668507,0.08822046,-0.04160568,-0.0022892954,0.09519616,0.0021734352,-0.05733632,0.013466033,-0.009257812,-0.027983582,-0.011683822,0.01208785,0.070441335,0.07822924,0.001634514,0.0655542,-0.005657506,0.01658608,-0.031423002,-0.0412218,0.08917575,0.077469036,-0.046448167,-0.018599698,0.049278174,0.053703442,-0.028416831,-0.07818712,-0.022665478,0.011135752,-0.031627722,0.025094932,-0.08421228,-0.09709359,0.09982471,0.0047081173,-0.08084387,-0.015083653,-0.053326495,-0.029534483,-0.013091511,0.016310045,0.0056019896,0.019519577,-0.07176659,0.029360646,0.0062284167,-2.1649669e-33,0.11962712,-0.10555911,0.03228543,-0.11041803,-0.08671867,0.037824456,-0.029639386,-0.05777642,0.019172247,-0.056713663,0.04584303,0.021776594,0.061760828,-0.031074202,0.07235229,-0.07666408,-0.058133468,-0.0069247186,-0.010232795,0.059098557,0.0026525115,0.043517,0.011953586,0.020961074,0.052343264,0.008911446,-0.003670703,0.07536129,0.011154101,0.029826827,0.04782993,0.016640374,-0.052954763,-0.019441754,-0.027234565,-0.012423136,0.009801723,-0.0047867526,-0.01698679,-0.0447191,0.036537055,0.03699191,-0.061926633,0.046926916,0.03170617,0.02020592,-0.029331194,0.07253627,-0.043326024,-0.0055097295,-0.0053755376,-0.060850535,-0.024966132,-0.039899897,0.069689445,0.017610252,-0.000119665565,0.018062448,-0.030149022,-0.021430029,-0.025469907,-0.08396159,0.049619384,-0.035475332,0.04174433,0.0543754,-0.009433152,-0.004588729,0.04067911,0.011962579,0.099488564,-0.007675277,-0.048306283,-0.0032243384,-0.062222824,-0.048009615,-0.048417777,0.00964423,0.0146901645,-0.07176886,-0.03746609,0.0010112852,-0.014356421,-0.041080993,0.036727734,-0.042658396,0.018045336,0.08507462,-0.013398494,0.023209354,-0.06444764,-0.07004384,-0.040716358,-0.040944654,-0.009261165,-2.6584235e-08,0.016944751,0.023260333,0.034924936,0.050123565,-0.013984035,0.09959137,0.03451123,0.04449659,0.0076003596,0.030452017,0.0067159766,0.061284993,0.10462999,-0.027761936,0.08092268,0.061487276,-0.03255326,0.081397176,-0.020297818,0.0010841046,-0.051404335,-0.08794706,-0.070402384,0.057883132,0.014791263,-0.0667149,0.05579412,0.08770099,-0.033137053,-0.055367805,0.015371741,-0.0212438,0.06930183,-0.08721675,-0.03858354,0.0650855,-0.025543232,0.037979726,0.01674768,0.0336462,-0.057698134,0.020892804,-0.041832224,-0.007418583,-0.05325929,-0.016623182,0.014566577,0.04693628,-0.021758135,-0.014222668,0.05019467,-0.025716512,0.002129946,-0.018854704,-0.038840912,0.023915077,-0.033102445,-0.060714994,0.009627495,0.047907352,0.0662692,0.016268265,0.052753128,-0.116794415 +5.4.99.59,The enzyme is involved in the biosynthesis of the Escherichia coli O52 O antigen.,384,1.0,-0.05519014,-0.019053178,-0.096112095,0.022837432,-0.0010898259,0.006817951,-0.05604823,0.05150762,0.069334626,-0.07127827,0.0061923815,0.01561931,-0.05322086,0.016157871,-0.024846215,0.06151496,-0.0022968543,0.05027294,-0.037150834,-0.07074123,0.08462533,-0.008326915,-0.032878097,-0.035449646,-0.0031302585,0.013297473,0.06781968,0.030249765,-0.0059016584,-0.08026992,-0.020106368,-0.037856188,0.055083014,-0.1000815,0.08014079,0.009661161,0.03277919,-0.116891816,0.08289229,-0.030694246,-0.0051792013,0.00013911133,0.012987537,0.0013841636,0.033544693,-0.008048533,0.00019922554,0.05794527,0.021435041,-0.034515772,-0.07115318,-0.05755415,-0.064713016,-0.0038161697,0.023126414,0.011015875,-0.02168589,-0.10719607,-0.029490447,0.023061385,0.005410014,-0.024844645,0.072157346,0.081469804,0.030163623,-0.09679282,0.06555935,-0.047692314,-0.026896067,-0.082283795,-0.1006653,-0.06267486,0.06675518,0.0682307,0.037711818,-0.024681518,-0.0023463324,0.0097685475,0.075973965,0.043259818,0.03483313,-0.039042383,-0.045197714,0.116370894,0.0010577078,0.021388886,0.015374591,0.040044915,0.06682804,0.050127164,-0.018823875,-0.09081121,-0.027971398,-0.1015443,-0.019355444,-0.04060959,0.03001277,-0.0018589266,0.045833927,-0.026686562,-0.040899683,0.0014407856,0.040947266,-0.025615426,-0.05400802,-0.030527873,0.026093343,0.12052159,-0.009556743,-0.010292076,-0.01635651,-0.057433564,0.036109813,-0.025049968,-0.032801744,0.075010695,-0.0130027225,-0.034776054,-0.036709685,0.022102006,0.014717639,-0.050541338,-0.024103891,0.116317086,-0.044297505,0.052180864,-0.07359582,-5.0526205e-34,0.06850981,0.023918776,-0.0088776965,-0.013968885,0.009264398,0.011455888,0.016583549,-0.04483789,-0.073026426,-0.003751067,-0.04840647,-0.11182418,0.057806365,-0.007890436,0.031161286,-0.0043380903,-0.033201367,-0.037757087,-0.032167554,0.03879909,0.034834277,0.062293228,-0.025457451,0.050390095,0.03601925,0.0899572,-0.07053231,-0.016605,0.0072869193,0.014716943,0.03840582,-0.032749485,-0.10149725,0.011995234,0.11636056,-0.07578064,-0.020672379,-0.0284478,0.00027532614,0.013057282,-0.035594903,0.05568151,-0.061512407,0.0063143345,0.05649067,-0.015150112,-0.01714938,0.05077866,0.07062156,0.068225145,0.024325695,-0.004425058,0.07959251,-0.04830613,-0.039722327,-0.0073786,-0.07093631,0.012609812,-0.0040768445,0.03755493,-0.048918277,0.053511485,0.014922611,0.03408008,-0.01619657,0.0077867755,0.0051803305,-0.039415438,0.024074174,0.13861394,-0.0002599072,-0.02150494,-0.012447572,-0.0011433606,-0.010594756,-0.038475677,-0.026025366,0.006975301,0.038792368,-0.033113576,0.04881011,-0.007592477,0.011246464,-0.019427653,-0.035370227,0.039014567,-0.053855933,0.0032094815,-0.010745303,0.10449698,0.09229146,-0.08042525,-0.033834778,0.02098775,0.020886466,-1.8979873e-33,0.08969226,-0.10748119,0.042689927,-0.08791924,-0.1215576,0.024769118,-0.022008209,0.038456272,0.024582833,0.037407476,-0.011087496,0.034196567,0.008710344,-0.022701086,-0.010509935,-0.008360022,-0.046518758,0.07964548,-0.026000448,0.015668275,-0.018604264,0.028757319,0.06379079,-0.06992476,0.053612318,0.08940915,0.0138392765,0.04964069,0.012697985,-0.012385752,-0.032592285,-0.022516971,-0.02978577,-0.052055713,-0.028664405,0.031895842,0.049234975,0.014963357,0.03283026,-0.011016088,-0.04823331,0.009967495,-0.026977096,0.06799489,-0.019430114,0.04835491,-0.009951246,0.051529676,0.023380369,-0.08676591,0.0230004,-0.020775111,-0.0078065014,-0.008888613,-0.031389266,-0.021880079,0.046526246,-0.029983368,-0.04214038,-0.0041603786,0.0211521,-0.038154505,0.058970086,0.0333455,0.046318423,0.08093051,0.036595676,0.04576401,0.0075195506,-0.022072388,0.006853954,-0.010588738,-0.03745023,0.0052569,0.04168012,-0.014018476,-0.119992584,-0.017233685,0.06504476,0.05933422,-0.083649024,-0.035795406,-0.03314912,0.045570172,-0.015803419,-0.09880927,0.05690845,0.121769175,0.059729107,0.026746694,-0.028733104,0.00523311,-0.034892444,0.054450165,0.030138308,-2.3971104e-08,0.07152605,-0.13246223,0.043541186,-0.039539568,0.009450901,0.09329593,-0.043005038,0.0021579578,0.046585366,0.0480472,0.024783216,0.107924424,-0.0014059687,-0.029036349,0.024091471,-0.01984634,-0.061767608,-0.015278333,-0.021492064,0.0065752454,-0.0019720427,-0.044481874,-0.064265795,0.053675186,0.034344137,-0.08128381,-0.0023723324,0.020876653,-0.019663474,-0.052247398,-0.08259027,-0.009891848,-0.038176954,-0.07202674,-0.1212165,0.027918264,-0.00091205264,-0.08939259,-0.01804921,0.002112665,0.05343134,-0.015575634,-0.035067763,0.0063893353,0.019020157,0.07793888,0.0030725442,-0.060575735,-0.045623183,-0.030381946,-0.019069932,-0.064711064,-0.01648024,0.014926262,-0.16542244,-0.051387034,0.026397247,-0.08978656,0.0174244,-0.0151101565,0.013177835,0.048628803,0.23614101,-0.065489836 +5.5.1.23,"The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.",384,1.0,-0.073970124,0.002121359,-0.1618009,0.007951822,0.03532523,0.048138987,-0.06782597,0.025575405,0.05493306,-0.03284924,-0.05792412,-0.0012419696,-0.0067479503,0.03242668,-0.03271164,0.08444095,-0.094211355,0.04895394,-0.07758491,-0.04057019,-0.008223733,0.015739918,0.096219584,-0.028239045,0.04871234,-0.03222374,-0.010158578,0.005403366,0.008546188,-0.027936328,0.06338418,-0.046299037,0.02179509,-0.030605987,0.022487309,0.08029347,-0.06678311,0.04529317,0.11377873,0.011912396,0.0270473,0.002261427,-0.049509626,0.030764455,-0.016085777,0.019532284,-0.04441684,-0.028831635,0.041986614,0.070946746,-0.0719228,0.005599769,-0.024575977,0.0026985104,0.06449401,-0.05268645,-0.039653964,-0.03171395,0.0058118184,0.010140629,0.11546513,-0.055528406,-0.011905369,0.046281137,-0.12948298,-0.089945905,0.050281025,-0.03666899,0.052112248,-0.019145679,0.006806392,-0.047911264,-0.005312315,0.018316515,-0.016769098,-0.030486528,0.017339138,0.011343976,-0.020619344,-0.034420803,0.0684492,0.0072660986,0.037522368,0.08326925,0.059487026,0.0020450654,0.05146174,0.018100964,0.051318903,0.108412415,0.024332223,0.0038901642,0.022252804,-0.046977237,-0.059214786,-0.0525317,0.055663064,0.029351503,0.011850794,0.022363521,-0.04523718,0.012595233,-0.028561221,-0.022987902,-0.03809025,-0.087098554,-0.035518784,0.012455323,-0.0524642,0.0004301806,0.012879234,-0.023442086,0.022566602,0.0037377465,-0.02080833,0.05985864,0.039175373,-0.0675685,-0.05292688,0.04947834,-0.030801464,-0.012024239,-0.01365112,0.09012613,0.017210875,-0.042560436,-0.065385886,3.63733e-33,0.014755788,0.054463793,-0.05582986,-0.048492767,0.059596606,-0.07307727,-0.08575346,0.0009930482,-0.026329976,0.016655393,0.0033380562,-0.057135798,0.038176935,0.033025116,-0.058129814,-0.04188509,0.03718697,-0.027527643,-0.0069719153,0.016979448,0.015672062,-0.0035210124,-0.03191221,0.08943527,-0.03262234,0.056432765,0.003898423,0.07224956,0.018042766,-0.022447364,-0.046757054,-0.09055536,-0.06029972,0.05766777,-0.013595996,0.009455898,-0.07297954,-0.013657709,0.02596626,0.0685147,0.0029301005,-0.031979743,-0.068568476,-0.0008202148,0.06959966,0.026088027,-0.08659343,0.13109805,0.045354497,0.0856259,0.014608219,-0.05207886,0.12267291,0.06211346,-0.014054773,0.010342862,-0.07087366,-0.015253796,0.029536191,0.009180687,-0.0060107717,-0.102591544,-0.009793599,0.032926608,-0.016945867,-0.024413211,-0.01091931,-0.03534337,-0.01343874,-0.0093170125,-0.02819823,0.026731588,0.02956762,0.0670728,0.0050463662,0.07427721,-0.111545876,-0.040321562,0.022026138,0.05060561,-0.05506211,-0.006544056,-0.016591491,0.015957521,-0.09137355,-0.011358801,0.006518236,-0.04527064,-0.009628683,-0.008886929,-0.05543147,-0.11729455,-0.04505487,0.044412293,0.06215422,-5.4276354e-33,0.12645015,-0.022686133,0.083492234,-0.06503647,-0.038633328,0.1037197,-0.002445701,0.0031983415,-0.009846906,0.054293916,0.03968948,-0.049357012,-0.0121252,0.011526512,-0.019957764,-0.04703212,0.055135,0.0774198,-0.007688162,-0.0027750232,-0.04621596,0.05575879,-0.056553807,-0.00034443074,0.008180946,0.07591301,-0.040687844,0.037565425,-0.037205715,0.13247213,-0.03609442,-0.023916984,-0.022723878,-0.032595254,0.00019171779,0.14805992,0.031555988,0.021342646,-0.05220847,0.036697153,0.020227313,0.029519072,-0.040327135,0.083815895,0.05381758,0.087748505,-0.03615298,0.066717915,0.014463859,-0.14493833,0.044110224,0.063004114,0.07803319,-0.0015940651,-0.015408615,0.066415556,0.005205467,-0.024183787,-0.009170158,-0.03327852,-0.022969877,-0.094122596,0.033747904,0.015445362,-0.058963444,0.068524376,0.011324039,0.027347015,0.03904603,-0.004039817,0.0118544055,0.057031214,0.010044691,0.067051105,-0.05691281,-0.004364458,0.019170165,-0.10680022,-0.013579205,-0.014915085,-0.0106448615,-0.011952382,-0.016343923,-0.02458443,-0.09943203,0.0008376294,0.058043126,0.012854279,-0.011316884,-0.022086978,-0.008176272,0.07496521,-0.049832564,0.077611305,0.045160342,-3.584687e-08,0.084658556,-0.053674206,0.045927424,-0.0714736,0.04663448,0.0081424,-0.047625132,-0.0018434271,0.010329958,-0.010679656,-0.057903614,0.07278195,0.0017027822,-0.0055016777,0.0023851562,-0.011796543,0.0011485813,0.0018879314,-0.011866994,-0.050355475,-0.035396114,-0.008014137,-0.080754295,-0.030538002,0.025414245,-0.069323465,-0.028979456,-0.021240886,-0.023760686,0.008165703,0.019804325,0.033345096,0.0047183116,-0.017950442,-0.059929684,0.008319654,-0.0051396936,-0.14269298,0.04711295,-0.08880296,0.0113870865,-0.0053617023,-0.09441136,0.026412586,-0.028902717,0.013231005,-0.035600774,-0.05274468,-0.024253262,-0.058786634,0.06328445,0.053335655,-0.0075332094,-0.0370411,-0.11824245,0.01992403,-0.03848832,-0.01724558,-0.05516541,-0.025037529,-0.054266945,0.0004156992,0.18346405,-0.09887058 +6.3.1.16,The enzyme is involved in the biosynthesis of the carbapenem beta-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum.,384,1.0,-0.036645025,-0.044745967,-0.04772749,0.025878036,-0.03313216,0.05681024,-0.11315897,0.025206534,0.06699193,-0.008971019,-0.00375509,-0.07589892,0.001232081,-0.019055642,-0.009049109,0.018179614,-0.06765256,0.0332951,0.054364514,0.0043540956,0.00045110416,0.0369035,-0.0024457434,0.0010290284,0.030171629,0.013946013,0.0655374,0.021624967,-0.031430747,-0.056484114,0.012524116,-0.0939297,0.07610701,-0.06378608,0.023878857,-0.006082684,-0.059822835,-0.08327081,0.12879865,-0.033855814,0.0038997757,0.041261286,-0.008960709,-0.03274307,0.016493736,0.02050113,0.02587987,0.047562227,0.022528855,-0.0863424,0.009264196,-0.043535136,-0.07363952,-0.012242762,0.007318665,0.0013143469,0.047310427,-0.0564138,-0.033463467,0.06011316,0.053703677,0.029480489,0.056479234,-0.0056852493,-0.061504442,-0.06339731,0.02235298,-0.061884873,-0.016210552,-0.035309482,-0.1326336,-0.11578272,0.035234094,-0.011826933,-0.035564516,-0.028596697,0.00051480404,0.010147384,0.05555408,0.011653576,0.021581713,-0.073456235,-0.022897456,0.045785002,-0.003083418,-0.060664617,0.07184371,-0.0072284355,0.08418561,0.070340306,0.03611196,-0.029098397,-0.026114514,-0.018989742,-0.06842092,-0.042128157,-0.0049754223,-0.012964608,0.016237989,-0.07471339,0.010317452,0.007360915,-0.007993699,-0.11317972,-0.06405046,0.00508021,0.027512869,0.06868246,0.020503707,-0.0033267564,-0.021132462,0.035009135,-0.030629897,-0.011823852,-0.11749878,0.037342206,0.032339603,-0.09275973,0.02568248,0.027611705,0.024032807,-0.040145732,0.0020842543,0.037828397,-0.050540686,-0.020302359,-0.03966584,2.5210265e-34,-0.0048300773,-0.014816083,0.046035748,0.0028425057,0.059394952,0.03644922,-0.08420751,0.01879477,-0.01481103,-0.0352567,-0.060273007,-0.06655383,0.05272781,0.036661897,0.0278415,0.0573073,-0.12617697,-0.005536258,0.059815403,0.01366831,0.020129623,0.038105424,-0.04795373,0.019902278,0.07063412,0.11628849,0.01448882,-0.0153291,0.04382141,-0.0066383067,-0.00068023766,-0.06648538,-0.08710661,-0.010228549,0.106893726,-0.008526207,0.033455327,0.016192934,-0.034794796,0.038072944,0.056902826,0.009572883,-0.025535885,-0.020085122,0.05481452,-0.0004314948,0.013861235,0.06641711,0.02229375,0.07882047,0.085076176,-0.0652407,0.05170577,0.065723605,-0.026211318,0.103160344,-0.07600436,0.04224454,0.02475536,-0.010569624,0.03996771,0.055442885,0.041607607,-0.029733336,-0.0018836944,0.06620718,-0.06484532,-0.0046792934,0.023614554,0.08991442,-0.035528906,0.007996141,0.006678155,0.016428953,0.02909978,0.02677444,-0.08468055,-0.007725645,0.03827402,-0.02997073,-0.04373114,-0.009855348,0.06932438,-0.06291277,0.0057185558,0.0020135615,-0.07982948,0.025796609,-0.0109704165,0.047085524,0.07177726,-0.056415435,-0.05806824,0.105818674,-0.022333497,-2.8695804e-33,0.10919154,-0.15332688,0.11464438,-0.01830977,0.0056995573,-0.0019142741,-0.084429026,-0.04163272,0.026144201,0.019105133,-0.024749435,0.01674416,0.08383907,-0.008838914,0.07420357,-0.016064832,0.00094163005,0.062191125,-0.07000015,-0.018237429,0.07527657,0.0025789568,0.03941121,0.0029898626,-0.00055175065,0.014680659,0.021197619,0.008066536,0.04378856,0.028593156,0.039006326,-0.054678176,-0.00079458655,-0.04777544,-0.10191314,0.047055453,-0.009160526,0.025425253,0.04233075,0.05896264,-0.0065138345,0.02863876,-0.046309266,0.04293404,-0.019229623,0.0009292715,-0.055839125,0.019383332,0.031905286,-0.05023963,0.05095358,-0.060820285,0.031214893,-0.04219674,-0.0096352,0.028127573,-0.0047171563,-0.021927778,0.045217376,0.015002543,-0.015961807,-0.024704741,0.04733472,-0.046989784,0.016684407,0.008221938,-0.009224573,0.053479787,0.07896237,-0.055482797,0.0444549,0.07711455,-0.06520453,0.092914484,-0.0058612125,0.05257685,-0.05577069,-0.10585462,0.055462755,0.022843504,0.014455045,-0.056054767,0.015351865,0.011030994,-0.11758613,-0.048248954,0.0043174378,0.09207658,0.017374052,0.034898534,-0.04322797,0.02493951,0.0012242517,0.09988169,0.0044855666,-3.209403e-08,0.053697463,-0.07719054,0.023027338,-0.010891381,-0.04676878,0.01755038,-0.07090462,-0.009312888,0.047063135,-0.06634532,0.048088882,0.027196797,-0.05668633,0.07191007,0.022470774,0.006053209,-0.012370057,-0.04560298,-0.015212871,0.062839374,-0.0898525,0.003149199,-0.051381495,0.02827615,0.06320164,-0.10885738,-0.024295028,0.016605178,-0.0797271,-0.009075102,0.0022369947,0.039804712,-0.044093926,-0.03157808,-0.1236818,0.019253517,-0.030928899,-0.09238157,-0.02860635,0.059844144,0.078314565,-0.045686834,-0.062255595,-0.023532744,-0.042323854,0.053478315,-0.051084783,-0.026864141,-0.0717915,-0.067902386,0.026321987,0.0250512,-0.07972945,0.06101185,-0.07293655,0.016710201,-0.0328382,-0.055280812,-0.0071512614,-0.028143805,-0.03742774,0.06654322,0.2099073,0.019666227 +6.3.3.6,The enzyme is involved in the biosynthesis of the carbapenem beta-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum.,384,1.0,-0.036645025,-0.044745967,-0.04772749,0.025878036,-0.03313216,0.05681024,-0.11315897,0.025206534,0.06699193,-0.008971019,-0.00375509,-0.07589892,0.001232081,-0.019055642,-0.009049109,0.018179614,-0.06765256,0.0332951,0.054364514,0.0043540956,0.00045110416,0.0369035,-0.0024457434,0.0010290284,0.030171629,0.013946013,0.0655374,0.021624967,-0.031430747,-0.056484114,0.012524116,-0.0939297,0.07610701,-0.06378608,0.023878857,-0.006082684,-0.059822835,-0.08327081,0.12879865,-0.033855814,0.0038997757,0.041261286,-0.008960709,-0.03274307,0.016493736,0.02050113,0.02587987,0.047562227,0.022528855,-0.0863424,0.009264196,-0.043535136,-0.07363952,-0.012242762,0.007318665,0.0013143469,0.047310427,-0.0564138,-0.033463467,0.06011316,0.053703677,0.029480489,0.056479234,-0.0056852493,-0.061504442,-0.06339731,0.02235298,-0.061884873,-0.016210552,-0.035309482,-0.1326336,-0.11578272,0.035234094,-0.011826933,-0.035564516,-0.028596697,0.00051480404,0.010147384,0.05555408,0.011653576,0.021581713,-0.073456235,-0.022897456,0.045785002,-0.003083418,-0.060664617,0.07184371,-0.0072284355,0.08418561,0.070340306,0.03611196,-0.029098397,-0.026114514,-0.018989742,-0.06842092,-0.042128157,-0.0049754223,-0.012964608,0.016237989,-0.07471339,0.010317452,0.007360915,-0.007993699,-0.11317972,-0.06405046,0.00508021,0.027512869,0.06868246,0.020503707,-0.0033267564,-0.021132462,0.035009135,-0.030629897,-0.011823852,-0.11749878,0.037342206,0.032339603,-0.09275973,0.02568248,0.027611705,0.024032807,-0.040145732,0.0020842543,0.037828397,-0.050540686,-0.020302359,-0.03966584,2.5210265e-34,-0.0048300773,-0.014816083,0.046035748,0.0028425057,0.059394952,0.03644922,-0.08420751,0.01879477,-0.01481103,-0.0352567,-0.060273007,-0.06655383,0.05272781,0.036661897,0.0278415,0.0573073,-0.12617697,-0.005536258,0.059815403,0.01366831,0.020129623,0.038105424,-0.04795373,0.019902278,0.07063412,0.11628849,0.01448882,-0.0153291,0.04382141,-0.0066383067,-0.00068023766,-0.06648538,-0.08710661,-0.010228549,0.106893726,-0.008526207,0.033455327,0.016192934,-0.034794796,0.038072944,0.056902826,0.009572883,-0.025535885,-0.020085122,0.05481452,-0.0004314948,0.013861235,0.06641711,0.02229375,0.07882047,0.085076176,-0.0652407,0.05170577,0.065723605,-0.026211318,0.103160344,-0.07600436,0.04224454,0.02475536,-0.010569624,0.03996771,0.055442885,0.041607607,-0.029733336,-0.0018836944,0.06620718,-0.06484532,-0.0046792934,0.023614554,0.08991442,-0.035528906,0.007996141,0.006678155,0.016428953,0.02909978,0.02677444,-0.08468055,-0.007725645,0.03827402,-0.02997073,-0.04373114,-0.009855348,0.06932438,-0.06291277,0.0057185558,0.0020135615,-0.07982948,0.025796609,-0.0109704165,0.047085524,0.07177726,-0.056415435,-0.05806824,0.105818674,-0.022333497,-2.8695804e-33,0.10919154,-0.15332688,0.11464438,-0.01830977,0.0056995573,-0.0019142741,-0.084429026,-0.04163272,0.026144201,0.019105133,-0.024749435,0.01674416,0.08383907,-0.008838914,0.07420357,-0.016064832,0.00094163005,0.062191125,-0.07000015,-0.018237429,0.07527657,0.0025789568,0.03941121,0.0029898626,-0.00055175065,0.014680659,0.021197619,0.008066536,0.04378856,0.028593156,0.039006326,-0.054678176,-0.00079458655,-0.04777544,-0.10191314,0.047055453,-0.009160526,0.025425253,0.04233075,0.05896264,-0.0065138345,0.02863876,-0.046309266,0.04293404,-0.019229623,0.0009292715,-0.055839125,0.019383332,0.031905286,-0.05023963,0.05095358,-0.060820285,0.031214893,-0.04219674,-0.0096352,0.028127573,-0.0047171563,-0.021927778,0.045217376,0.015002543,-0.015961807,-0.024704741,0.04733472,-0.046989784,0.016684407,0.008221938,-0.009224573,0.053479787,0.07896237,-0.055482797,0.0444549,0.07711455,-0.06520453,0.092914484,-0.0058612125,0.05257685,-0.05577069,-0.10585462,0.055462755,0.022843504,0.014455045,-0.056054767,0.015351865,0.011030994,-0.11758613,-0.048248954,0.0043174378,0.09207658,0.017374052,0.034898534,-0.04322797,0.02493951,0.0012242517,0.09988169,0.0044855666,-3.209403e-08,0.053697463,-0.07719054,0.023027338,-0.010891381,-0.04676878,0.01755038,-0.07090462,-0.009312888,0.047063135,-0.06634532,0.048088882,0.027196797,-0.05668633,0.07191007,0.022470774,0.006053209,-0.012370057,-0.04560298,-0.015212871,0.062839374,-0.0898525,0.003149199,-0.051381495,0.02827615,0.06320164,-0.10885738,-0.024295028,0.016605178,-0.0797271,-0.009075102,0.0022369947,0.039804712,-0.044093926,-0.03157808,-0.1236818,0.019253517,-0.030928899,-0.09238157,-0.02860635,0.059844144,0.078314565,-0.045686834,-0.062255595,-0.023532744,-0.042323854,0.053478315,-0.051084783,-0.026864141,-0.0717915,-0.067902386,0.026321987,0.0250512,-0.07972945,0.06101185,-0.07293655,0.016710201,-0.0328382,-0.055280812,-0.0071512614,-0.028143805,-0.03742774,0.06654322,0.2099073,0.019666227 +6.5.1.5,"The enzyme, which is specific for GTP, was characterized from the archaeon Pyrococcus furiosus. The enzyme converts the 3'-terminal phosphate of various RNA substrates into the 2',3'-cyclic phosphodiester in a GTP-dependent reaction. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by GTP, forming a phosphoramide bond between guanylate and a histidine residue. The guanylate group is then transferred to the 3'-phosphate terminus of the substrate, forming the capped structure [RNA]-3'-(5'-diphosphoguanosine). Finally, the enzyme catalyses an attack of the vicinal O-2' on the 3'-phosphorus, which results in formation of cyclic phosphate and release of the guanylate. cf. EC 6.5.1.4, RNA 3'-terminal-phosphate cyclase (ATP).",384,1.0,-0.056309674,-0.052673817,-0.03303949,-0.0808834,0.05301169,0.023069864,-0.043909624,0.01823177,0.048595805,0.03576245,0.01870526,0.0020933535,-0.0654018,0.07645,-0.04654321,0.007799651,-0.11091764,-0.019194728,0.070603035,-0.00443663,0.12011102,0.038948856,-0.036619246,0.0014745181,-0.00877784,-0.006214696,0.06148771,-0.012832488,0.0021808266,-0.022706904,-0.09011256,-0.0309415,0.021047309,-0.043786507,0.032691482,0.09500067,-0.044259183,-0.031047499,0.018104112,0.042870313,0.06168514,0.015926024,-0.03931645,-0.02068782,-0.019361837,0.038316853,0.090683356,0.053073563,0.026726304,-0.041016635,-0.029031642,-0.035176896,-0.035342913,-0.0064004925,-0.029920144,0.06488751,-0.080954075,-0.047378257,-0.010171136,-0.050106812,0.008507976,0.0036722878,-0.032332845,-0.016347367,0.07274993,-0.019249981,0.037397888,-0.030359693,-0.013930552,-0.0008564445,-0.03243216,-0.020217394,-0.014153075,-0.01856977,-0.043664344,0.11843462,-0.017244356,-0.032958753,0.048959713,-0.009268112,0.042277742,0.014776519,0.06261009,0.04914339,0.03407481,-0.03399616,0.043183304,0.081907146,0.010704355,0.016281135,0.0308187,-0.017422132,0.04216485,-0.023961436,-0.017928604,0.041815247,0.0022304864,-0.015691439,0.042144608,-0.027199237,0.044083517,0.04645127,0.044857133,-0.09624083,-0.042043846,0.06620492,-0.046119075,0.05029787,0.051465932,0.044593908,-0.0619107,0.055366397,-0.021458866,-0.04019281,-0.05900359,0.12274757,-0.028038753,-0.053229995,-0.088350825,0.08116817,0.03299798,-0.053176217,-0.03423278,0.04097787,-0.079295225,0.08253817,-0.09861321,1.0853941e-33,0.033600844,0.0063723107,0.00094075996,-0.04181688,0.06977058,0.02851375,-0.09045068,-0.03867696,-0.09674728,-0.0028344581,-0.090296715,-0.04942558,0.045791216,0.011456569,-0.070906356,0.038183227,-0.07541432,0.040595684,0.046696164,-0.04020815,0.041388225,0.048511427,-0.011977195,0.012995274,0.0092774285,0.07849592,-0.09252429,-0.0466847,0.026414266,-0.023212656,0.039719705,-0.10638623,-0.15096177,0.042378545,0.06419367,-0.06698673,-0.029518664,-0.11495407,0.02296574,0.020571956,-0.022683369,-0.03207189,-0.0016530951,-0.010409015,0.061843675,-0.055570483,-0.039232228,0.010003692,0.010157314,0.044788633,0.10368659,-0.039553225,0.03639411,0.026240123,-0.062022857,-0.030531771,-0.048280016,-0.060556393,0.036576197,0.023707878,0.07596337,0.029485317,0.027067006,0.023555845,-0.029650006,0.044738866,-0.10842272,-0.054240365,0.06420342,0.13339902,-0.024041628,-0.04283256,0.00961561,0.013459646,-0.02661151,-0.026030632,-0.018099831,0.026100457,-0.014556181,0.057009537,-0.022170575,-0.034470543,0.03271457,0.018829407,-0.06831532,-0.01270164,0.019718235,-0.06368566,0.003457816,0.109722495,0.037809886,-0.01391128,-0.04195026,0.02884724,-0.0031883197,-1.5767907e-33,0.14358807,-0.065047346,0.060789276,-0.11264128,-0.10335201,0.03047053,0.04043659,-0.094985805,-0.012371823,-0.0945901,0.014347438,0.026211707,0.06520417,-0.005176811,0.0004567719,-0.020713413,0.07356932,0.071876235,-0.029635912,-0.024908623,0.06153652,0.006617834,-0.030554721,0.014679,0.0318333,-0.011892186,0.036891095,0.011607987,0.038854066,0.074179105,-0.010780892,0.028222246,-0.056984138,-0.015529949,0.03805209,0.012299086,0.0014545132,-0.013440771,0.03586801,0.0027151727,0.016594678,0.06440388,0.06947604,0.022077624,0.03134928,0.10477535,-0.004715751,-0.012397413,-0.018085334,-0.062385283,0.06904531,-0.0018040714,0.0015614273,0.05040183,0.051817518,-0.02133524,0.008532153,-0.056176096,-0.027777793,-0.010229876,-0.03643987,-0.085429735,-0.04216347,-0.05051513,0.050023943,0.06041667,0.019720484,0.027481686,0.006162173,0.02126681,-0.0079972735,0.04761373,0.06660222,0.0035552345,-0.03343169,0.057915572,-0.0002778012,-0.028030429,0.067332566,-0.09691282,0.01216558,-0.0038196812,-0.00957197,-0.05157599,-0.023140458,-0.06875684,0.08703067,0.14376602,0.06174343,-0.01450033,-0.004052324,-0.030295301,0.0077968794,0.061628763,0.095201276,-4.85239e-08,0.015275343,-0.01454004,0.021697301,-0.05319068,0.00036476567,0.06856962,0.024245257,0.027283786,0.07100291,-0.06697032,0.040241934,0.007213768,0.044040035,-0.03367138,0.0929901,0.013119323,-0.06530214,0.020619642,-0.005950186,-0.050427556,-0.12269133,0.02801631,-0.14145365,0.05145582,-0.0051356647,-0.02791883,0.04955266,0.01455239,-0.020877047,-0.00079845585,0.033778843,0.0028877822,0.010068546,-0.03323138,-0.038298063,0.009034577,-0.040212955,0.005078154,-0.0026831902,-0.057432905,0.021077458,-0.0027965752,-0.052760143,-0.03599741,-0.06428392,0.015816625,-0.026725888,0.03792274,-0.0494285,0.06603343,0.08841208,0.037578326,0.012292753,-0.0061062276,-0.07600158,-0.07237902,-0.0005023296,-0.113517895,-0.05885272,-0.05923989,-0.025247468,0.013733925,0.14370836,-0.029662045 +1.1.1.364,"The enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.",384,1.0,-0.016200017,-0.027521614,-0.04699561,-0.044864062,0.03417006,-0.08545652,0.046247337,0.097667746,0.036024943,0.06781912,0.018852586,-0.011641523,0.046490856,0.06646995,-0.05647615,0.035653315,-0.04029271,0.028740576,-0.015561226,0.0063630412,-0.007518827,0.080440715,0.03644415,0.033964083,0.05839886,-0.027355371,-0.004958294,0.108348556,-0.042726003,-0.0918745,0.027083615,-0.07748742,0.039684936,0.030861901,0.08770918,0.010079426,-0.06600716,0.015241271,0.09414248,0.001137389,0.016140826,-0.04782758,-0.024144772,0.02603972,0.0065653683,-0.004145561,-0.07091478,-0.02417351,0.063513,0.092205964,0.0028759025,-0.0010144891,-0.044256147,0.053945087,0.07190484,0.019705221,-0.019173829,0.012141549,-0.06224402,-0.04007013,0.038245756,-0.028572235,0.012049442,0.05999578,-0.06412892,-0.014289982,0.014570955,0.011768742,0.0018066156,-0.01815715,-0.06006494,-0.057043392,0.028474266,0.049352847,0.07405819,-0.06801501,-0.027265593,-0.013438309,-0.021527627,0.007359372,0.034402754,-0.0037213361,0.023680497,0.034238268,0.02266854,-0.010136126,0.11135732,0.0014165783,0.06638721,0.06884265,0.018663514,-0.015052719,-0.040712044,-0.037596285,-0.037554465,-0.055148486,0.008802678,-0.0025109039,0.016847316,-0.038149145,-0.028215101,-0.020467466,-0.05910057,-0.09307304,-0.026448041,0.051233925,-0.010835898,-0.0049732733,0.036095217,-0.018961396,0.026214696,-0.016214864,0.09976658,0.010748876,-0.00054130243,0.12886637,0.1016229,-0.045832373,-0.038774934,-0.063536875,-0.018223988,-0.02098554,0.014430995,0.029568462,-0.108437195,0.05096933,-0.013090733,9.738635e-34,0.0333611,0.06680285,-0.06995303,0.06430993,0.02644783,-0.04971358,-0.085640855,-0.0033678794,-0.121675774,-0.016777096,-0.094038896,-0.071806535,0.031270772,0.08140221,-0.08375009,0.014864924,0.078212745,0.0056524454,0.0097512,0.021265766,0.03203965,0.04135749,-0.034058057,-0.023712713,0.052086364,0.12480884,-0.026052697,0.08782204,0.07120174,-0.029896114,-0.04486758,-0.088575825,-0.02473725,0.016079595,0.037845198,0.017936613,-0.057535112,-0.013840086,0.07639905,0.03316297,-0.035388764,-0.0334075,0.021820748,-0.055625074,0.044270292,-0.06339121,-0.04732065,0.09214939,0.024294376,0.039500166,0.0827065,-0.11766414,0.022628112,-0.044363562,-0.04506686,0.009147992,-0.027910722,0.013142384,0.04263715,0.056495905,0.01563167,0.003014573,-0.071149476,0.030883506,0.01744555,0.0034375738,-0.04636117,-0.00082268286,-0.0491991,0.03751179,-0.07829959,-0.039954044,0.031044938,-0.010139228,0.07538714,0.0386387,-0.05690019,-0.005127966,0.06089561,-0.001011229,0.0036073814,-0.027483214,-0.08499522,-0.020485736,-0.020860227,-0.014991365,-0.030122817,-0.06180622,-0.012415415,0.023829892,-0.047948122,-0.118070155,-0.037487116,-0.0064844326,-0.024676029,-3.3386493e-33,0.08317775,-0.056753583,0.07627617,-0.06709279,-0.044987846,0.1090343,0.015414152,0.0037952617,0.06662265,0.020171477,0.061952136,-0.009324608,-0.03379841,-0.08120258,-0.046486117,-0.014226636,0.031698994,0.013087743,-0.06426254,-0.03980092,-0.012748966,0.0922747,0.02488246,-0.03268934,0.03512963,-0.0011929402,0.031543493,0.09480706,0.070604675,0.06659728,-0.034139816,-0.0380807,0.009707138,-0.031995144,-0.019364279,0.11998088,-0.051351555,-0.02205538,-0.03815263,-0.06474317,-0.0583754,-0.0394703,-0.010512355,0.09388771,-0.00071892864,0.061794724,-0.16338494,-2.6960612e-05,0.019445792,0.007448157,-0.013685484,0.030992933,0.071814634,0.01760042,0.0028317915,0.02576747,0.06941954,-0.044010725,-0.023011258,-0.012612613,-0.0038866505,-0.046209253,0.022501513,0.011280493,0.008243227,0.054228578,-0.08425485,0.031042192,0.043389805,-0.05056476,0.012806888,-0.006692706,-0.06744438,-0.038749743,-0.050561834,-0.001172914,-0.02993741,-0.034341127,0.080225065,0.02602333,-0.05831539,0.027931495,0.02046292,-0.040158957,-0.03373536,-0.06112137,-0.027092734,0.055534694,-0.00935272,-0.01327395,0.0046549323,0.073819555,-0.05059081,0.009849046,0.009638944,-3.7724238e-08,0.038599376,-0.038842056,0.07037573,-0.032704283,0.03783606,-0.023539683,-0.05978032,-0.013420584,0.010335481,-0.021423029,-0.03605958,0.12688465,-0.012765633,-0.08184688,-0.014775774,0.043583345,-0.013725129,-0.016538834,-0.024653224,-0.019593816,-0.042970654,-0.011489589,-0.087237395,0.033294443,0.08103715,-0.033123896,-0.005877342,0.009648415,-0.027547738,0.010802755,0.06639939,-0.0020561968,-0.035243854,-0.025216943,-0.11013943,0.022897618,-0.09229226,-0.039526746,0.03727252,-0.013578721,0.107802734,-0.0030251616,-0.03873026,0.01584273,-0.110632084,0.050664604,0.00021276597,-0.060562048,-0.0001809184,0.03214078,0.09014817,0.010221749,-0.020827211,-0.004645304,-0.14670625,0.028991817,0.023525074,-0.013447972,0.029493714,-0.065559916,-0.015474678,-0.037281573,0.19671346,-0.02768983 +1.1.1.365,"The enzyme from plants is involved in ascorbic acid (vitamin C) biosynthesis [1,2]. The enzyme from the fungus Trichoderma reesei (Hypocrea jecorina) is involved in a eukaryotic degradation pathway of D-galacturonate. It is also active with D-glucuronate and glyceraldehyde [3]. Neither enzyme shows any activity with NADH.",384,1.0,-0.04208184,-0.022599699,-0.09668089,-0.032207754,0.01150242,0.064842515,-0.06881627,0.01788315,0.024633715,0.07501213,0.020189468,-0.006185893,-0.08936202,0.009684028,-0.10116278,0.0020063468,-0.033337362,0.037458993,0.002634622,-0.0071384334,0.06622759,0.04311619,0.030786432,0.012117625,0.0740929,-0.029520016,0.03691303,-0.060887706,-0.08989978,-0.045237232,-0.041608013,-0.05557978,0.020253902,0.0019212501,0.0051193563,0.09344736,-0.041971635,-0.0348695,0.082851335,0.06816337,-0.013313953,-0.014706957,-0.037191052,-0.0075510554,-0.020006735,0.009397038,-0.052323833,0.05591737,-0.0041524405,0.011436861,-0.035870526,0.014814902,-0.0078120325,-0.06312235,0.049021337,0.05939344,0.048500746,-0.042371504,-0.0030834165,0.05825611,0.08173167,-0.02044934,0.026035938,0.0052808095,-0.0012766517,-0.07017823,0.026984908,-0.018880686,0.00030456402,-0.08402767,-0.03308193,-0.07165786,-0.024508823,-0.052938346,0.015670322,0.048665524,-0.024889136,-0.049658045,0.0660417,-0.074138656,0.071896404,0.033243377,0.023276143,0.023866728,0.0019124438,-0.013895121,0.029153025,0.03656671,0.028749913,0.02154575,0.04883919,-0.05298369,-0.06696639,0.01896225,-0.16201833,-0.0007645487,0.076380484,-0.041343506,0.012413579,-0.07091023,-0.00022478851,0.00042389796,0.0711507,-0.06684415,-0.021354105,0.06261182,-0.03753141,0.07811498,0.07963272,0.039301485,-0.032480612,0.007485285,-0.06447275,0.0067840084,-0.041349337,0.11370513,0.07891766,-0.028898232,-0.09733981,-0.03260042,0.027214112,-0.022932243,0.036933552,0.017554184,-0.006513446,0.027444987,-0.038379565,2.218116e-33,0.08304364,0.023833875,-0.056765713,-0.03070535,0.0026667428,0.024196472,-0.062361524,0.021579709,0.013839374,-0.09201836,-0.044859245,-0.08127863,0.005380127,0.060101658,-0.012588941,0.07562883,0.0007875605,-0.11716592,0.023678267,0.0036337755,0.030463707,0.07727375,-0.06958157,0.025028307,0.07170249,-0.00033821928,-0.006307586,0.07606506,0.06801457,-0.021334043,0.06196975,-0.1080671,-0.08492834,-0.031882845,0.1434218,0.015996391,-0.014675951,-0.019183379,-0.007720949,0.003177334,-0.038103264,0.0024564108,0.021010194,-0.06447682,-0.0033692848,-0.050411448,-0.0027466055,0.09386491,0.031204907,0.01893519,0.026887905,-0.00021515865,0.08562207,0.046418972,-0.023832705,0.05493515,-0.039810088,-0.033050448,0.05865131,0.06329594,0.025415283,0.0068841875,-0.019071648,0.071814954,-0.02594061,0.021235475,-0.09994738,-0.036769114,0.019490296,0.028913552,-0.047529627,-0.049226422,0.031181164,-0.018271524,-0.06469677,-0.006921151,-0.035903253,-0.01720185,-0.032253236,-0.04876848,0.008137668,-0.006006679,0.0047516017,0.014643589,-0.011848311,0.052670054,-0.022272198,-0.047150698,-0.005324917,-0.0036677106,0.028270222,0.009085781,-0.033252016,-0.026082365,0.04774063,-4.6563638e-33,0.08486707,-0.051827088,0.09219662,-0.04609463,-0.009853154,0.11417461,-0.011748093,-0.026111886,-0.054272395,-0.107077554,-0.020198451,0.029397042,0.0011956886,-0.038203053,0.055800647,0.016376698,-0.02017074,0.14910616,-0.056341268,0.028415203,0.014154518,0.085337006,-0.026152981,-0.038354743,0.057738937,-0.05901054,-0.043573435,0.048741102,-0.012968012,0.02675763,0.0443929,0.027053867,-0.054795697,-0.04829631,0.0041296734,0.03851219,-0.049143393,-0.036471292,-0.02955308,0.049438834,0.010775834,-0.018327987,-0.013943349,0.062075857,0.07090412,0.064045765,-0.09688663,0.042934183,0.0034613623,0.016828135,0.05229357,-0.049025703,-0.0008021785,0.032268416,0.049871437,0.022388455,0.06354471,-0.012632627,0.015435795,-0.03323546,-0.044593155,-0.055902325,0.03747185,-0.06968508,0.07117485,-0.01135347,0.012896548,0.085117,0.06965885,-0.056397785,0.14158647,0.06081929,4.2656044e-05,0.06488548,-0.05169042,-0.0362124,-0.12902223,-0.0123057775,-0.015087407,0.01523018,0.06426197,0.028021093,0.058113452,-0.009149745,-0.038559563,-0.03544442,0.052440416,0.06483281,-0.059175435,0.018295877,-0.035427846,-0.010191854,-0.033627275,0.048238885,0.025234537,-3.671579e-08,0.06520358,0.046235856,0.015269176,-0.13431518,-0.027079418,-0.04192062,0.084235884,0.046116635,0.018007929,0.0016817185,-0.022123035,0.11579438,-0.012084141,0.061050955,-0.0068889344,-0.006330508,-0.011638769,0.06528491,-0.029156432,0.04268098,-0.058595162,-0.01516961,-0.13322273,0.06996986,-0.062115125,-0.06665952,0.0466492,0.032181878,0.019914927,-0.080223195,0.035080995,0.03258461,0.07583103,-0.068760864,-0.08987974,0.027179834,-0.02358388,-0.00517848,0.012483765,0.057980128,-0.017548712,-0.051853843,-0.01648347,0.022637254,-0.052231334,-0.06849801,0.0061007715,0.013792765,-0.045035895,0.0324686,-0.031099986,0.007953616,-0.079275064,-0.066452384,-0.09833505,-0.05463111,-0.015382284,-0.03911399,-0.047098465,-0.095391914,0.01886315,-0.039009675,0.10550961,-0.04600532 +1.1.1.366,"Involved in the catabolism of ascorbate (vitamin C) to tartrate. No activity is observed with NADP+ (cf. EC 1.1.1.264, L-idonate 5-dehydrogenase).",384,1.0,-0.056373913,0.018466469,-0.099556334,0.055299733,0.024725439,0.0667417,-0.042705756,0.08125336,-0.023503095,0.0072308425,0.005725751,-0.0015874536,-0.07160528,-0.0077855475,-0.088455595,-0.021892851,0.025594268,0.028245198,-0.028981809,0.0006234241,0.0182523,-0.0011095626,0.09575042,-0.033307735,0.09902511,0.014998914,-0.01768259,-0.024888447,-0.03709424,-0.059641413,-0.03669091,-0.010097695,0.0064085857,-0.034999266,0.0039691254,0.09531712,-0.04300325,-0.013425468,0.058112532,0.040342145,0.050286382,-0.031018423,-0.08885606,0.034602165,-0.00049303216,-0.04116869,-0.008628674,0.020671425,-0.02414532,0.052599683,-0.04372699,0.042194024,-0.023623861,0.008503334,-0.073910534,-0.036106404,-0.0002826733,-0.05388035,-0.05791975,-0.029116811,-0.034335148,-0.023573788,-0.003365694,0.009649669,0.059877716,-0.0529962,0.05042942,-0.021194814,0.012172562,-0.059478834,-0.0642809,-0.05035189,0.047299884,0.05570299,-0.021418657,0.06942048,-0.036146827,-0.006608529,0.006156057,-0.03309323,0.04491346,0.016509915,-0.049062327,0.062166315,-0.019126602,0.012611781,-0.012863736,0.013027293,0.0032275075,0.0854231,-0.001419153,0.029347245,-0.06792228,-0.007897309,-0.13225158,-0.01577905,0.13109586,0.02900212,-0.01574927,-0.060730837,-0.050697986,0.0920038,-0.0046706744,-0.03746035,0.003089461,-0.027593846,-0.050944414,-0.006034596,0.03244367,-0.0023366518,0.0037252496,0.008402536,-0.07356536,-0.005544947,0.07086984,0.123153515,0.059717465,-0.058221094,-0.10256926,-0.028324166,0.01190053,-0.012499372,0.0817275,0.03925657,-0.05876328,-0.024685184,0.018303206,-1.2662649e-33,0.050662003,0.01474466,-0.010372887,0.051154982,-0.019096334,0.053271458,-0.08092466,0.0692161,0.046798594,-0.029244615,-0.070174254,-0.067239925,0.09672672,0.027367154,-0.064836666,-0.0011683971,0.0032619077,-0.09165305,0.043004695,-0.045233175,0.0599228,0.058924723,-0.00027998665,0.028804317,-0.04196291,-0.011582915,-0.012349031,0.07793005,0.024139483,-0.032324716,0.100497134,-0.0669107,-0.08389529,-0.051314153,0.109742306,0.042833887,-0.048327196,0.017176056,0.004661319,0.09719873,-0.04871911,0.041409638,0.015383829,-0.07787282,0.013306194,-0.058646876,0.03234692,0.04322308,0.0007235677,0.04473196,0.037915688,0.0355164,0.12835568,-0.011635322,-0.0024449737,0.045385774,-0.034910433,-0.062092796,-0.040784255,0.109812565,0.074199475,0.023727985,-0.024762897,0.03486474,-0.08691432,0.015066731,-0.1216937,-0.03188577,0.064705394,0.015176112,0.0037082927,-0.015776785,0.09935222,-0.019112928,-0.008322782,0.07142039,-0.09184602,0.062277988,-0.024065925,-0.06306429,0.00010266228,-0.01022031,-0.013609551,0.01524712,0.01720596,0.07244237,0.026254887,-0.049828704,-0.020435093,0.00071676855,0.038022768,0.008049475,-0.022286776,-0.12540431,0.1159949,-1.667531e-33,0.13286798,-0.049918845,0.0054869032,-0.046484854,0.006164037,0.063632414,0.08402327,-0.063817166,-0.087986745,-0.022526398,0.05941514,0.054998003,0.014007872,0.0061249165,0.051167537,0.03588906,-0.053928893,0.12224209,-0.006877659,0.05765773,0.0015017512,0.054336257,-0.028841708,0.03825865,0.031443432,-0.0137370825,0.0025567233,-0.031301174,0.03589837,-0.036750317,0.085164346,0.030443909,-0.043028317,-0.05513291,0.011625757,0.07951767,-0.07284742,-0.023700533,-0.08260213,-0.016985668,-0.009917916,0.011896543,-0.07563126,0.0043617818,0.05559024,0.004282203,-0.12650517,0.0012499783,-0.014583159,0.007312663,0.09385554,-0.017747814,-0.055226207,-0.001012643,0.08712545,0.07152828,0.010286234,-0.010230781,0.020971477,0.0020347727,-0.0015050918,-0.023957985,0.017473588,-0.10648381,0.048574917,-0.035423547,0.052439984,0.04417409,0.026134584,-0.028621342,0.069537506,0.003449954,-0.005958369,-0.039321624,-0.04670443,-0.028344182,-0.018117774,-0.0073079364,-0.0056500826,-0.05696994,-0.053918414,-0.038691644,0.008374293,-0.051369537,-0.035803277,-0.050050188,-0.026993206,0.022359537,-0.045545403,0.033613443,-0.024212575,-0.05694242,-0.056674358,0.055150397,0.09100602,-3.1139667e-08,0.02716164,0.05853539,0.037321344,0.025712024,-0.011886682,0.0005529513,0.016659815,-0.033553153,0.01666626,-0.01450089,0.025763355,0.109535016,0.06570781,0.053872462,0.009138481,-0.01968283,-0.029371202,0.038117655,-0.016968053,-0.030748723,-0.083753325,-0.032516107,-0.119310774,0.01518095,0.04313031,-0.07346674,-0.0026088324,0.0057385834,0.06902688,-0.10407233,0.084552854,-0.003351109,0.11267881,-0.09804362,0.017030798,0.012900565,0.02784566,-0.0009792988,0.013378618,0.09384332,-0.05266258,-0.0601514,-0.06950594,0.038846534,-0.0234556,0.025099708,-0.017351303,0.017586797,-0.117075525,0.03906529,0.012108181,0.02180692,-0.021934964,-0.010913104,-0.030404463,0.0394504,-0.04063728,-0.049307995,-0.059815757,-0.047122996,0.015655005,-0.011838058,0.037658073,-0.060016822 +1.1.98.4,An enzyme complex that contains FAD and iron-sulfur clusters. The enzyme has been described in the archaea Methanosarcina mazei and Archaeoglobus fulgidus.,384,1.0,-0.05520172,-0.052365795,-0.11514247,0.033980407,0.080001034,-0.02138556,-0.0769316,-0.030989446,0.035764135,-0.03785271,-0.033715628,-0.0775308,-0.018504871,-0.008633061,-0.06283283,-0.0092298435,-0.07052546,-0.004652688,0.005649207,-0.02988475,0.049545676,0.04184153,0.0039431723,-6.5971435e-05,-0.047692016,0.05418152,0.029400999,-0.044099573,-0.054405212,-0.034016736,0.003305282,-0.020652084,0.06786619,-0.027327135,0.052320823,0.100693054,0.014337713,-0.038355276,0.020488754,-0.05850413,0.019971337,0.0388969,0.07249211,-0.04080704,-0.05993762,-0.024307547,0.023788242,-0.025452897,0.057083387,-0.037717514,-0.06479086,-0.08868105,-0.064474165,0.06320568,0.0269035,0.059733994,0.027453542,-0.10424664,-0.0072268634,-0.026822755,0.05203302,-0.010994498,0.025997235,-0.042669874,0.00040948272,0.0063739032,0.027296878,-0.028555863,0.06654442,-0.062491704,-0.023313584,0.024240216,-0.043031245,-0.027456263,-0.020534942,0.052827124,-0.02364563,-0.08286567,0.09659677,-0.015938664,-0.040616937,0.010070926,0.08558489,0.07064172,0.03657361,-0.03565287,0.06720165,0.00048699544,0.010631086,-0.0077513554,0.028228953,-0.0063935774,-0.06288132,-0.06972838,-0.032015298,-0.00320583,0.012918511,0.069564186,0.0115768965,-0.016845128,-0.006396965,0.009672256,0.0066525238,-0.12283399,-0.0871636,-0.04013677,-0.018933032,0.1557776,0.056801382,0.04759913,-0.024139542,-0.024909073,0.0722753,0.0043311967,0.0016963463,0.03663287,0.08084747,-0.07094319,-0.06072362,0.019007044,0.020547614,0.025827788,0.10424121,0.0723803,0.033174932,-0.016302235,-0.16805464,1.1154302e-33,0.0503863,0.02343649,-0.0021518935,-0.035021883,0.013519521,-0.064146176,-0.11283227,0.02383855,0.0010988746,0.024584591,-0.119400516,-0.01522718,0.014298645,-0.059415862,-0.018044544,-0.027649155,-0.007015445,-0.03287793,0.026187483,-0.04921949,0.0069059636,0.07545172,0.009605236,-0.029143088,0.011788558,0.03138306,-0.014667171,0.00915432,0.020491242,0.02247692,0.07784916,-0.16273493,-0.13601656,0.01570561,0.07348723,0.09420858,-0.014221628,-0.060019564,-0.100570545,-0.008525648,0.006262407,0.015589857,0.029518796,-0.025804494,0.0626624,-0.03209318,-0.047835056,0.08845136,0.03925124,0.021015435,-0.028469682,-0.02088128,0.08741552,-0.0023399103,-0.12083612,0.0011113326,-0.013745677,0.006114724,0.07253754,0.07472339,0.027477348,0.03773365,-0.019402979,0.100285575,0.005990881,0.04330884,-0.011607723,0.036175653,0.08180293,0.12387547,-0.031685024,0.01126227,0.03325424,0.0444068,0.014891175,-0.05823618,0.010431792,-0.06051387,-0.036617577,0.011487657,-0.033426702,-0.14463736,-0.018918648,0.0052463985,-0.02850721,0.028765222,-0.029211767,0.037844952,-0.016393399,-0.003862819,0.021776715,-0.029489284,0.011045851,0.034903806,-0.016330967,-2.3698592e-33,0.039168008,-0.09646132,0.0743361,-0.10094667,-0.08461679,0.09191017,-0.027082998,0.016347049,0.022188557,-0.010704669,0.094775654,-0.030806007,0.049868274,-0.08602459,0.033212774,0.020435086,0.033316597,0.017684113,0.10483997,0.01979841,-0.01979877,0.038417384,-0.028307522,-0.02425643,0.03167264,0.01999845,0.040749416,0.014373826,0.025731158,0.07238794,0.01645639,0.0371425,-0.03028208,-0.061692074,-0.0969205,-0.055422824,-0.031811904,-0.06768233,0.029511683,-0.016019681,0.027341926,0.019756103,-0.011286515,0.12539953,0.030539397,0.0075555863,-0.08237035,0.030777695,-0.0069925687,-0.02518807,0.0116174,-0.07485871,0.01853312,-0.08178932,0.033409946,0.0377104,-0.0047426545,0.072363146,-0.034097727,0.021706164,-0.023082279,-0.09574207,0.05061199,-0.0074448725,0.047901586,0.024037769,-0.026192585,0.025749493,-0.036165528,0.05038576,0.046700075,0.038644418,-0.028819995,0.0856889,0.036720764,-0.010322532,-0.020877823,0.07392872,0.030852508,0.01654212,0.045354813,0.024374925,0.011850965,-0.048886515,0.048609484,-0.061962776,0.039974708,0.12788223,-0.015028945,5.1145602e-05,-0.05793505,0.005822761,-0.029296577,-0.040987033,-0.018713329,-2.6851472e-08,0.021184476,-0.0053674197,0.0356061,-0.035395503,0.0015414972,0.047181092,0.030804537,0.006041948,-0.059003625,0.022678828,0.0122693395,0.12328281,-0.013278741,-0.028329313,0.00031537403,0.06445108,-0.05463182,0.008121727,-0.02043991,0.032808714,-0.00037679038,0.026788445,-0.055344805,0.05943017,-0.0007519544,-0.047675278,0.032749508,-0.00907275,-0.06294049,-0.07210239,-0.03690095,0.03231613,-0.015722066,-0.024460267,-0.09835306,0.045348097,-0.03900014,-0.038229875,-0.0577642,0.028381027,0.036753558,-0.014832994,-0.01827906,-0.030824278,0.012581489,0.016185606,-0.0036056335,0.04501794,-0.033978134,0.023842651,0.057784494,0.043339305,0.039980527,-0.024420017,-0.084758334,0.0027292918,0.009359964,-0.10821774,-0.03228045,0.011976499,0.12788734,-0.041480385,0.07331574,-0.052450966 +1.1.98.5,The enzyme isolated from the methanogenic archaea Methanogenium liminatans catalyses the reversible oxidation of various secondary and cyclic alcohols to the corresponding ketones.,384,0.99999994,-0.06458212,-0.029465484,-0.030216593,0.005336185,0.0948254,0.029021451,-0.12310534,-0.084157996,0.022685746,0.0021746184,-0.013422842,-0.072213456,-0.10809463,-0.028011234,-0.060555305,0.044512235,-0.07701234,0.018609121,0.09295635,0.015743341,0.030853719,0.054260045,0.003936923,0.027057186,0.05011419,0.12660904,0.03393997,0.023642695,-0.012584468,-0.07621242,0.054318972,-0.029004242,0.0661632,-0.032923833,0.025284031,0.091021925,-0.06215565,-0.003084651,0.08461107,-0.030920997,-0.0045160283,0.027120521,0.09457449,-0.014680567,-0.04693081,-0.0032876742,-0.00064287416,0.014179806,0.0450003,-0.06784158,0.031485848,-0.052119337,-0.021775184,0.023113318,0.08218355,0.04833961,-0.022731893,-0.020147953,0.039768413,0.017350545,0.03781837,0.029779023,-0.002730026,-0.017991362,-0.056862593,-0.08659383,0.05230752,-0.051905125,0.111311145,-0.029687611,-0.036163613,-0.022510938,-0.014159614,-0.0706495,-0.046954434,-0.037564218,-0.042608794,-0.047924377,-0.0051576034,-0.064146556,0.0019868226,-0.002709155,0.07154577,-0.00822355,0.049690552,-0.025836175,-0.03328058,-0.031166984,0.05650404,-0.019058231,0.018915921,0.009847168,0.05878236,-0.08532168,-0.022508528,-0.005392282,0.058288183,0.10505349,0.0034216843,0.010243639,0.036033597,0.039771054,-0.063771315,-0.05557027,-0.0794179,-0.032690737,0.051976666,0.07408807,-0.002698531,0.064846076,0.06335497,0.004574889,0.09923117,-0.017868929,-0.019466875,0.058335014,0.02698901,-0.076159954,-0.053335063,0.034362167,-0.062062204,0.0062669637,0.10634389,0.004290341,-0.05535167,0.058224194,-0.030610168,1.4610094e-33,0.026925717,0.008986984,-0.06593631,-0.051477365,0.028438421,-0.069962054,-0.06296743,0.0013077616,-0.0036309278,-0.061012384,-0.035098758,0.053865273,0.029823987,-0.06880027,-0.005965198,-0.020703554,0.04883791,-0.03844014,0.057665076,-0.018648798,-0.089978725,-0.038083076,-0.032913268,0.04061321,-0.036427908,-0.012835034,0.046713095,0.009719027,0.054703172,0.00762925,-0.015334898,-0.0021571333,-0.07300587,0.012179671,0.04127161,0.091971405,-0.054680645,0.0002684541,-0.05215894,0.06603921,-0.001304431,0.03748684,0.014316293,-0.0356783,-0.015169268,0.06284924,-0.043594997,0.14295536,0.022981044,0.021809226,0.0064850673,-0.057006843,-0.00048425084,-0.016868783,-0.10028437,0.040374506,-0.0062120333,-0.05726531,0.052611344,0.050751112,-0.0403795,0.029316707,0.0016275411,0.047251903,-0.037347574,0.013791145,-0.05602953,0.01988586,0.019090028,0.054294344,-0.049956776,0.052046437,0.08775509,0.06012337,-0.027265148,0.017013302,1.6358943e-05,-0.032435305,0.010951977,0.025934963,0.023698526,-0.060272083,0.033026196,-0.048381038,0.029381638,-0.0020312953,-0.049221765,-0.018415371,0.02629479,0.03969277,-0.042440016,-0.091076456,0.030511102,0.036286384,-0.019330945,-2.4581752e-33,0.09652361,-0.06942717,0.044650972,-0.119927615,-0.04996389,0.082884,-0.029137338,-0.039697032,-0.02661039,-0.06954391,0.07783308,0.009713685,0.057695713,-0.014479537,0.03456487,-0.05952419,-0.0034201536,0.11572436,0.0016185903,-0.023635665,0.074905306,0.026134573,-0.093538,-0.032369204,0.04288817,0.02052362,-0.04401249,0.090935744,0.06042876,0.02421249,0.027894467,-0.03925567,-0.009072627,-0.0075338944,-0.022950435,0.055717178,-0.08504908,-0.007708955,-0.01850391,0.05918733,0.015970178,0.057349343,-0.069745466,-0.0020125983,0.061880387,0.01618927,-0.07668586,-0.025904384,0.009068009,-0.114561096,0.07878889,-0.056259774,-0.05587158,-0.023600431,-0.030137777,0.07647213,0.004819829,0.07780569,0.023994766,-0.012378807,-0.051174525,-0.056427885,0.06725651,-0.022651035,-0.00069476286,0.011197241,-0.009494857,0.059418254,-0.046237096,0.016937338,-0.029771134,0.002581789,0.05454128,0.09304714,0.006823853,-0.068428785,-0.09278138,-0.006387488,0.00041426969,-0.08146485,0.041072812,-0.051806286,0.04344139,-0.030489333,-0.005359062,-0.06612659,0.07594056,0.019620202,-0.018462902,0.0316264,-0.01928199,0.00993786,-0.05330144,0.049635634,0.043844488,-2.7622695e-08,0.03991724,-0.021527542,0.08939051,0.05653836,0.032704115,0.1246188,0.08758394,-0.023504043,0.016352331,-0.07727271,-0.021724598,0.048014928,0.054884236,0.0010786297,-0.041493565,0.08813419,-0.05539172,-0.05109063,-0.026226806,-0.01277393,0.010526262,0.0051587042,0.04243528,0.012488673,-0.06914765,-0.059752006,0.02327863,0.063943245,-0.049825083,-0.05929664,-0.036790524,0.03513302,-0.01344737,-0.008016457,-0.06175433,-0.03490756,-0.022622598,-0.0819779,-0.05539495,0.02607734,-0.0260181,-0.077218376,-0.0854149,0.021936005,-0.0072984495,-0.047361527,-0.02300618,0.06304398,-0.048001718,0.07945678,0.060434937,0.053249918,0.04288219,0.008698426,-0.035946235,-0.020868188,-0.02700856,0.022132691,-0.14008678,-0.06499064,0.08028298,-0.03397929,0.12722544,-0.02283339 +1.1.99.39,"Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.",384,0.99999994,-0.026592001,-0.033853013,-0.036901653,0.019353883,0.08413892,0.035202753,-0.05821727,0.06297237,-0.026098326,0.05218376,-0.02433991,0.032165837,-0.07434565,0.08121424,-0.022768306,-0.017192218,4.4796423e-05,-0.03964971,0.04990156,-0.0100825885,0.034439694,-0.011670086,0.03415321,-0.050026193,0.08835737,-0.014173614,0.03452913,-0.05049916,0.028106792,0.016044425,-0.056469534,-0.019804958,0.03195318,-0.06390257,-0.011721589,0.010537642,0.030476552,-0.028425982,0.0056692515,-0.003817637,0.05070144,-0.02232938,-0.01109663,-0.016457843,-0.006396782,-0.043298755,0.033776544,-0.056269415,-0.04222551,0.08255729,-0.050280657,-0.06993563,0.03405353,0.040699314,-0.02193365,0.01924946,-0.03728525,-0.03909795,-0.029239386,-0.04334953,-0.005735783,-0.07476544,-0.0051173423,0.02898122,0.091106184,-0.024922403,-0.01772964,-0.017346645,-0.0055017625,-0.08637103,-0.020365763,-0.047748372,0.022584658,-0.025351416,-0.02653565,0.001802808,-0.006248635,-0.06330128,0.08165586,0.0122267995,0.034895845,-0.018885706,0.042840052,0.118554786,0.063077606,0.05515931,-0.00061754056,0.038624488,-0.08588575,0.036073342,0.041411705,0.0012385652,-0.06989835,-0.007823048,-0.110682555,0.014340714,0.007367402,0.033680297,-0.027852748,-0.030974599,0.047748026,0.07026924,-0.015940707,-0.11570735,-0.055249386,0.04962458,-0.012217025,0.077593856,-0.024721786,0.037146423,-0.02942812,0.025987312,0.015936956,-0.011698869,-0.0036856104,0.08370391,0.024383109,-0.08471529,-0.091668546,-0.03734292,-0.0051235682,0.0007964339,0.07613192,0.058662754,0.014792136,0.018136764,-0.042244576,1.4422912e-33,0.014099827,0.013116842,-0.0473781,-0.04853651,0.0109056495,0.09913748,-0.03377543,0.0724038,0.036422156,-0.04467598,-0.10189029,-0.07701121,0.04679788,0.00024743783,-0.016662678,0.013467322,0.03686386,-0.10577213,0.11255515,-0.036543883,0.08051829,0.035548013,-0.003919098,0.038271718,0.02226371,-0.0065150084,-0.04951785,0.075531,-0.02228943,-0.022770151,0.042302515,-0.14801991,-0.081777625,0.009658735,0.078857444,0.027394963,-0.05171196,-0.028884016,-0.05756294,0.013751873,0.008095383,-0.011948291,-0.017113164,-0.015198211,0.044729598,-0.089904316,-0.059482913,0.018933438,0.039318204,0.040989395,0.0884825,-0.01172925,0.0055838665,-0.042204358,-0.088247165,0.05981824,-0.020881299,-0.0034865083,0.016430842,0.053013034,-0.0024418535,0.011479837,0.013399568,0.107625835,-0.04146648,0.056487326,-0.06902695,-0.08135444,-0.0030726024,0.11212046,-0.017293235,-0.023323016,0.05497395,-0.00012509715,0.06954773,-0.06692634,-0.011157991,0.035410874,0.07616821,0.0042167273,-0.007657875,-0.056148373,-0.030427478,0.024646983,-0.018838018,0.0064948504,-0.015208517,-0.034026407,0.08836061,0.027201753,0.07408648,-0.08262153,-0.07514655,0.00043895608,0.06234425,-3.598419e-33,0.052651376,-0.0492627,0.06585456,-0.10088811,-0.053830553,0.11609294,0.052395523,-0.093872145,0.04389439,-0.08971396,0.09857112,0.006261943,-0.0027692437,-0.006638732,0.032107882,0.03661282,-0.07574855,0.07554797,0.07600907,-0.013427133,-0.03512945,0.07022541,0.045625884,0.035331767,0.058996163,-0.035971567,-0.018132087,0.015497169,0.11040453,0.050099213,0.022646502,0.036434397,-0.09584912,-0.08168478,-0.025854189,0.02920358,-0.046238553,-0.003492568,-0.05753203,-0.016305229,0.009376524,0.00915779,-0.053223193,0.08411863,0.036557697,0.01650518,-0.11848372,-0.05987479,-0.021715932,-0.038220506,0.058693487,0.014412186,-0.02708857,-0.02306975,0.12046567,0.060266815,-0.015579132,0.0130956555,0.04208317,-0.004798881,-0.039793346,-0.04196282,-0.030476963,-0.046914756,0.07844417,-0.0042081275,-0.00792059,0.03825943,-0.0012145678,0.012059587,0.10566177,0.06956659,-0.016311375,0.05882429,-0.031623416,0.052366666,-0.052290533,0.012006397,0.003194628,-0.056674067,0.019653767,0.035446767,-0.05423045,-0.02022819,-0.09608041,-0.010580397,-0.019432213,0.07884692,0.0012824329,0.0083765285,-0.024944883,0.025718171,-0.06340619,-0.04035683,0.022492029,-4.6133003e-08,-0.004670388,-0.04033048,0.041019026,-0.06446851,-0.034654465,0.022475854,0.041967977,-0.05140552,-0.018045865,0.024489043,-0.05113404,0.13741703,-0.017746981,0.006478533,0.025030382,-0.037737675,-0.0033456571,0.045831062,-0.028568713,0.026802769,-0.059221197,0.020274766,-0.12165134,0.058989655,0.021442266,-0.0531195,0.024463944,0.036395762,0.020343302,-0.07564787,0.022955602,0.00029502908,0.10136825,-0.054552615,-0.064801134,0.07324446,0.063004725,-0.044398658,-0.094912514,0.047319964,-0.0274489,-0.0547927,0.027546484,-0.0344663,-0.06167251,-0.03088938,0.040642302,-0.039773468,-0.028518492,-0.034850664,0.010548404,-0.0633641,-0.039623767,-0.10037962,-0.034575395,0.0015957667,-0.0006051187,-0.09495523,-0.016932983,-0.045968663,0.058180414,-0.012319465,0.12728496,-0.045066558 +1.3.1.105,"The enzyme was dicovered in strawberry (Fragaria x ananassa), where it produces furaneol, one of the major aroma compounds in the fruits. It has also been detected in tomato (Solanum lycopersicum) and pineapple (Ananas comosus). The enzyme can also act on derivatives substituted at the methylene functional group. The enzyme from the yeast Saccharomyces cerevisiae acts on (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one and produces homofuraneol, an important aroma compound in soy sauce and miso. NADPH is the preferred cofactor.",384,1.0,0.01671202,-0.078518234,-0.08274877,-0.015676565,0.1316301,0.07674806,-0.0659934,0.008851004,0.10182004,-0.016857076,0.07811326,-0.009484201,-0.08890496,-0.01741165,0.004238267,0.07258739,0.008411155,-0.02313198,-0.0044550663,-0.08103576,0.10162072,0.03429626,0.021747159,0.019869471,-0.027367543,-0.100662805,0.016480923,-0.012209252,-0.052248836,-0.08421855,0.020777864,0.0234555,0.0041147806,-0.04532822,-0.047807172,0.037642352,0.03868798,-0.083393686,0.12585591,-0.024182968,-0.018211512,-0.033101182,-0.030247549,-0.014525018,-0.059099052,-0.033949833,-0.007568552,0.0031511511,0.07427899,-0.00047828682,-0.074116856,-0.05335252,0.01494704,-0.04723521,-0.005092057,-0.0038035386,-0.0018825631,-0.012187325,-0.005909345,0.05074971,0.013309829,-0.039101157,-0.012652208,-0.014782503,-0.04763535,-0.06858834,0.024879543,-0.0407526,0.06556066,-0.058826957,-0.11087469,-0.09071204,-0.016952414,-0.02330557,-0.041228767,0.12997775,-0.013884194,-0.039367475,0.03862229,-0.020092273,0.015586811,0.041175548,0.03264493,0.034500252,0.07282794,0.032597367,-0.02316579,0.02143629,0.026582876,0.035515886,0.04468755,-0.011297885,-0.036012206,0.013542641,-0.06429429,0.036834482,0.046200562,0.043607246,0.022847494,-0.02031916,0.012579286,-0.0008160491,-0.040642604,-0.11091442,-0.09836039,0.019332709,0.009096671,0.02253654,0.0647955,0.0067664334,-0.059582487,-0.03087323,-0.027141092,-0.0026229946,-0.06155295,0.051460136,0.0439754,-0.015692595,-0.05556387,-0.019768937,0.03405256,0.03397383,0.117321275,0.030053059,-0.028494677,0.02286248,-0.08767713,3.9609527e-33,0.029163608,0.060753554,-0.03556091,0.0007274814,0.039459642,-0.02053115,-0.049581517,0.05279618,0.024820473,-0.016598368,-0.07326478,-0.030053236,-0.044075545,-0.026733844,-0.063772336,-0.05322317,0.017904216,-0.024128074,0.013758479,0.018404858,-0.017623521,0.076150164,-0.01892254,-0.0063646166,-0.06945259,-0.0040201135,-0.03914903,0.006848368,0.044950668,-0.009005797,0.046456587,-0.09772937,-0.065140106,0.013879532,0.049882993,0.010034492,-0.055268016,-0.017864548,-0.039155435,0.053716097,0.005281002,0.01637408,0.048107196,0.0125489775,-0.018748555,-0.011232025,-0.06550818,0.092698954,0.03353938,0.03221108,-0.05627303,-0.00057330413,0.11808899,0.023333661,-0.013253612,-0.009255605,-0.020189825,-0.019085377,0.049879026,-0.0047765514,-0.11126064,0.045020368,0.020645324,0.0050711543,-0.06076663,-0.016175913,-0.057855915,-0.025362045,0.05093433,0.116940424,0.044462178,0.040557295,0.018457381,0.030625757,0.045982,-0.0665316,-0.05371618,0.019822383,0.018707875,0.040004633,-0.03482446,-0.06589466,-0.011578359,0.01814994,-0.086103275,0.036324777,-0.065725796,0.0008704094,0.05044069,0.045261834,0.014899297,-0.045926254,0.06540763,0.016516583,0.04670232,-4.1129394e-33,0.060057603,-0.02724632,0.05595393,-0.06475056,-0.027470622,0.10176003,0.07225012,-0.1017519,-0.034811854,-0.087285675,0.039857753,0.009984543,0.046915784,-0.02085467,-0.0059755547,0.1240343,0.03619015,0.061513133,0.013137271,0.0024508808,-0.059686214,0.08921077,-0.01068588,0.05062895,0.11426297,0.021958781,0.059985526,0.010595139,0.0030295085,0.013962673,0.05373756,-0.03282147,0.031795613,-0.026054813,0.018450588,0.03845409,-0.07109965,-0.024830502,-0.0057211826,0.09323406,-0.018428326,0.05942873,-0.031945147,0.05029417,0.012458732,0.028691635,-0.13222025,-0.01532206,0.028558642,0.0068917917,0.019239366,0.019565944,-0.033424713,-0.027601331,0.048038475,0.058464225,-0.012735576,0.032266892,-0.051862378,0.04189037,-0.03154247,-0.041889474,-0.03533091,-0.0035708765,0.048374884,0.04898273,-0.05171136,0.0100637125,0.006975448,0.03986412,0.08511205,0.030879315,-0.00810401,0.07231615,-0.06121573,-0.044203494,-0.0027537504,-0.06892739,-0.085023575,0.0012035216,0.016416162,-0.023094734,-0.015350838,-0.06322979,-0.046116777,-0.064271905,0.025053812,0.08279097,-0.028975418,0.0071724514,-0.0025511116,0.0009985556,-0.07449265,0.09252839,0.13815783,-4.6978062e-08,-0.019331891,-0.11362722,0.063584395,-0.05370632,0.0071988804,0.04365876,0.016395101,-0.028643409,-0.021674205,-0.000101048056,-0.07073859,0.09284919,0.016157191,0.09299629,0.036829047,-0.04986156,0.017075133,0.09422316,-0.011501278,-0.018895851,-0.060353763,0.0144317495,-0.12105428,-0.024983346,0.02767224,-0.06872305,-0.006742644,0.04946585,0.06720454,-0.027775252,-0.002299664,0.027427968,0.018975092,-0.021572934,-0.055801727,0.08168017,-0.061102893,-0.031713035,-0.08130693,0.04196207,0.0006125495,-0.031243145,-0.033053633,-0.011508782,-0.031065043,-0.070118934,0.051803652,-0.003605917,-0.01485142,0.09975402,0.042156383,0.06025789,0.03837,0.021980353,-0.021782039,-0.045511596,0.00060843484,-0.04901591,-0.024318464,-0.08380212,0.05019566,-0.013351558,0.1943628,-0.06734601 +1.3.8.11,"Contains FAD. The enzyme, characterized from the strict anaerobic bacterium Syntrophus aciditrophicus, is involved in production of cyclohexane-1-carboxylate, a byproduct produced by that organism during fermentation of benzoate and crotonate to acetate.",384,0.99999994,-0.03730253,-0.054096866,-0.06904614,-0.0061811716,0.08200535,0.05440981,-0.031953286,0.031140793,0.008585831,-0.038059276,-0.015970822,-0.110013306,-0.03076951,0.01590419,-0.10425032,-0.010208713,-0.028802305,-0.08333829,-0.0076846695,-0.06702172,0.041764762,0.04050247,0.0167966,0.018875116,0.008579125,-0.053835686,-0.018899582,-0.023304978,-0.032676548,0.02731147,-0.020275328,0.05158643,0.049475335,-0.0014251312,0.07376571,0.08417751,-0.004379647,-0.029107215,0.092676595,0.050420757,-0.015311557,0.007531692,0.008799565,0.006839585,0.03600254,0.05160674,0.031518478,-0.00061854604,-0.01682896,-0.07335779,-0.028236615,-0.001537594,-4.2867585e-05,-0.010548696,0.004763884,0.037708182,-0.0056542447,-0.052090615,-0.03813524,0.018134518,0.032344103,0.06417006,-0.009780183,-0.01852261,0.028057693,-0.076199606,-0.013755927,-0.014536603,0.023616372,-0.0015159182,-0.06951823,-0.08290702,-0.020179966,-0.011335438,0.017887628,-0.021056304,-0.04631826,-0.09552831,0.0062913513,-0.06530592,0.0599408,-0.011664548,0.04383817,0.019374654,0.04586144,-0.022558972,0.06670016,0.031142173,-0.0023141294,0.041448314,0.0037923797,-0.0476847,0.004178189,-0.09391847,-0.061357107,0.032142796,0.046194095,-0.012876085,0.041440234,-0.021227393,-0.0059741354,0.07657245,0.07578304,-0.088939585,-0.06245622,-0.026029272,-0.001180973,0.16263679,0.025149118,0.020004323,-0.018321032,0.010720634,0.00586558,-0.045954358,-0.012834121,0.047232594,0.0013856759,-0.08401907,-0.039812554,0.005033161,0.00959819,-0.04558658,0.015304909,0.11617925,0.009760901,0.029441793,-0.12545605,5.1391184e-33,0.08444805,-0.03564815,-0.053734414,-0.06198835,-0.01706983,-0.0072308625,-0.10053335,-0.012404428,0.02865885,-0.006091601,-0.03064919,-0.06695645,0.016889874,0.010038603,-0.031626575,0.021645585,-0.14983872,-0.004437198,0.027849816,-0.017280823,-0.030097665,0.082538545,-0.015248278,0.032823417,0.032461774,-0.009014445,-0.03315473,0.021025067,0.041435458,-0.010558897,0.016780246,-0.062201235,-0.09856903,0.014896384,0.018715246,0.012290755,-0.08371163,-0.07166962,-0.04743057,0.07232046,0.06501513,0.036060236,0.058031913,-0.0517741,0.048905477,-0.020620331,-0.07254497,0.11549254,0.027095892,0.05429763,0.042382568,-0.0098970095,0.081575125,-0.028130723,-0.033922564,0.042335883,-0.0453211,0.04641969,0.067929484,0.04968595,-0.012715222,0.033705696,-0.058479887,0.085157685,-0.038566936,0.010687471,-0.056413982,-0.032832146,0.008525631,0.098007955,-0.065150365,-0.074395545,0.012874692,0.075851455,0.08411585,-0.06352664,-0.02748536,-0.038853902,-0.0016461952,-0.019408908,-0.023709549,-0.067545705,-0.006434786,-0.045957994,-0.05728683,-0.0009744523,-0.06286264,-0.008179633,0.014199152,0.04075524,-0.0055639558,-0.08942302,-0.010928447,0.09350646,0.0148408385,-5.9786488e-33,0.085308835,-0.06347184,0.09159763,-0.08862475,-0.0085262675,0.100803114,0.004506995,-0.04189968,-0.0042815534,-0.03648136,0.055276893,-0.004044666,0.0035075552,0.007922326,-0.011564705,-0.024709826,0.03397597,0.06822,0.003046597,0.07684378,-0.048908744,0.044259988,0.05502428,0.016377388,0.050431762,0.04715768,-0.048337832,0.0874709,0.025394147,0.016556375,0.036166914,0.037853368,-0.034812056,-0.07539142,-0.12260306,0.03368249,-0.027527615,-0.001520678,-0.02882256,0.054093845,0.0095511945,0.018371148,-0.052337904,0.11427105,0.045213684,0.025987724,-0.11252635,-0.032067336,0.05794357,-0.04736344,0.009681725,-0.0123853125,0.030282136,-0.07486241,0.05334772,0.081025615,0.02054723,0.02427752,-0.008608521,-0.015060835,-0.020679371,-0.023535673,0.04022394,-0.041305594,0.08732356,0.0029676869,-0.014983606,0.108741865,0.042734835,0.045795318,0.09429278,0.08953211,-0.020410022,0.066917844,-0.03698661,-0.0036521878,-0.055859905,-0.022572927,0.055748887,-0.010239383,0.027189279,0.030275831,-0.011996915,0.033817988,-0.08235701,-0.09080133,-0.0044774455,0.06549768,0.0014851756,0.016190032,0.0029404818,0.0017652519,0.008650557,0.034145515,0.0692389,-4.114556e-08,0.07857083,-0.08087185,0.035683136,-0.06366442,0.008030218,0.025828326,0.029949712,-0.024461018,-0.018548286,-0.07189365,-0.047622133,0.07153485,-0.012680588,0.011586893,0.038820878,-0.015688987,-0.08045105,0.05638401,-0.062868744,0.05111073,-0.053031627,0.012967901,-0.08596592,0.074473344,-0.036306415,-0.057085376,0.07762414,0.04482546,-0.030439662,-0.008427636,-0.008076235,0.03148513,-0.0028133886,-0.015432987,-0.08223998,0.013935881,-0.013612319,-0.07412953,-0.09451758,-0.032750405,0.0134279225,-0.0019027226,-0.076272406,-0.052370153,0.039619025,-0.020109395,-0.021181073,-0.026169604,-0.04081556,-0.026743837,0.060972538,-0.027709208,0.018130422,0.005024195,-0.052757874,0.0016822414,-0.020108625,-0.07956818,-0.001904942,-0.057876788,0.024806924,0.069493,0.2358496,-0.032877292 +1.5.3.22,The enzyme contains FMN and a binuclear iron center. The enzyme from the archaeon Methanothermobacter marburgensis is Si-face specific with respect to C-5 of coenzyme F420 [2]. ,384,1.0,-0.031553756,0.00087579613,-0.08628957,0.039739743,0.098188855,0.05700796,-0.11428606,0.08367351,0.018951984,-0.045131437,-0.027368149,-0.11968382,-0.063139915,0.0023297882,-0.040099494,-0.02720336,-0.07276641,-0.008034809,0.0061800806,-0.005749579,0.017125793,0.03576686,-0.0042108893,-0.050413422,-0.055045847,-0.033210993,0.045942012,0.007975024,-0.017980624,-0.055333946,0.026128622,-0.03936247,0.11359152,0.0070499745,0.05248891,0.030845406,-0.029189274,-0.06696661,0.07548122,0.015421858,-0.011692775,0.021505564,0.065225266,-0.06688673,-0.016789572,0.0071142893,0.00989847,0.003762705,0.05295769,0.0020312888,-0.067681246,-0.11171144,-0.039274495,0.07733169,0.030051159,0.07459236,0.0039047461,-0.100627765,-0.0072621107,0.06868777,0.060940538,0.042091697,-0.03330707,-0.031514615,0.004871752,0.019264037,0.005644955,-0.08067326,0.067490846,-0.029391069,0.0052935844,-0.022963706,-0.07623392,-0.04926411,-0.03713752,0.0031519786,0.0031957184,-0.038254056,0.086074874,-0.009886997,-0.05421685,0.022336926,0.025346711,0.031144269,0.008999617,-0.02724753,-0.04210412,0.017660776,0.026381187,0.0030290652,-0.0030771166,-0.008833454,-0.08166782,-0.08822463,-0.07832289,0.04007257,0.06123818,0.07581821,0.0049200063,0.019996053,-0.014740109,0.0012317698,-0.015625142,-0.080722585,-0.085300215,-0.013052426,0.034858134,0.13044932,0.06388616,0.009583365,0.012663161,0.02955035,0.049857255,-0.061250977,0.012124779,-0.010339688,0.045725573,-0.08771983,0.028817907,0.062267583,0.052302822,-0.017587066,0.05708645,0.020569902,0.002325629,0.04661111,-0.14752041,1.5247014e-33,0.033783536,0.049668077,0.03280795,-0.0398213,0.01947473,-0.041446485,-0.024746655,0.0411009,-0.06979904,-0.016975012,-0.14590622,-0.04612281,0.034329973,-0.026248012,-0.05397902,-0.028005714,-0.005798807,-0.060995486,0.0038637028,-0.010971136,0.04112117,0.05128687,-0.0021358565,0.019574217,0.023738477,0.014169572,-0.022345217,0.03239175,-0.0053229616,0.0058609173,0.010201512,-0.062239308,-0.07823354,-0.036176898,0.12548676,-0.0061106137,-0.028724214,-0.018563757,-0.09862406,0.013649458,0.10155304,0.02920645,-0.019601401,-0.011974292,0.10568589,0.003231112,-0.09307436,0.110777296,0.0760928,0.04170967,0.049213413,0.017406492,-0.0070004496,0.015269941,-0.045288783,0.03612226,-0.010553736,0.039760362,0.029304827,0.07628338,0.018614525,0.035106853,0.0102038905,0.08513153,0.06320945,0.024560591,-0.03724659,0.028028218,0.02956123,0.07432133,-0.04359382,0.049138334,0.014600433,0.028896825,-0.006112835,-0.032928973,-0.0066939183,-0.021307955,0.07308605,-0.022162346,0.010520125,-0.013518398,-0.01043003,-0.02795456,-0.09514706,-0.029161096,-0.0032008472,-0.016444733,0.019656412,0.01353329,0.07460531,-0.103680454,-0.05977001,0.048827574,-0.07525757,-2.3671626e-33,9.498631e-05,-0.112804934,0.02966249,-0.086374834,-0.09685153,0.10046178,0.007396403,-0.057799753,-0.015579917,0.0053634406,0.15658145,-0.023193527,0.036379486,-0.06482086,0.008965699,0.04745397,0.012955293,0.057208024,0.046948206,0.056086928,-0.020249836,0.061515022,-0.027703065,-0.052869145,0.0155147,0.015596468,0.02268072,0.08331061,0.037375975,0.0876194,0.03104044,0.009953134,0.011656449,-0.08068054,-0.08845129,-0.03744593,-0.0394902,-0.046492778,0.05671451,0.007994156,0.02250682,0.018003536,-0.01877903,0.12322868,0.04267893,0.03288343,-0.089022465,-0.075501345,-0.0012158055,-0.021713758,0.0071295747,-0.1267517,-0.04419275,-0.041676693,-0.035844494,0.031671688,0.01532888,0.06254653,0.0066101793,0.013895204,-0.00449739,-0.056477558,0.06299887,0.0017368044,0.093026176,0.07376369,-0.01726377,0.07913605,0.017818876,-0.025903987,0.049120832,0.029918885,0.071286775,0.05415397,-0.01482674,0.0006041705,-0.015988346,0.07794279,-0.057656933,0.054946613,0.0050662933,-0.036962613,-0.005027155,-0.0448161,-0.020103903,-0.054214798,0.033285316,0.053215303,0.034561567,-0.0025726368,-0.06426377,0.035841715,-0.05579592,-0.04459483,0.058049075,-3.048396e-08,0.008420951,-0.05252789,-0.0023025423,-0.10097992,0.004016459,0.033524573,0.046347965,-0.079215504,-0.026411831,0.049340982,-0.029525615,0.09458661,-0.033402607,-0.022293314,0.019718764,0.005965182,-0.009674305,0.024721289,-0.017997619,0.029142117,-0.073646046,0.045956027,-0.003449679,-0.04187031,-0.016486838,-0.084940955,0.0069882716,0.08988936,0.0067876424,0.0074028815,-0.03849356,0.06634022,0.008760901,-0.03597518,-0.11639935,0.025954323,-0.038925547,-0.047987957,-0.08195714,0.043184202,0.029045431,-0.023634363,-0.078882664,-0.013375484,0.008061879,-0.0372732,0.021645974,0.07319662,-0.009860034,-0.030168632,0.017514143,-0.023971848,-0.018563492,0.0071858396,-0.101516634,0.013974618,0.0023395824,-0.051542282,-0.025798092,-0.05142825,0.032876167,-0.02141423,0.11751381,-0.00049033057 +1.5.7.2,The enzyme from the archaeon Methanosarcina mazei contains iron-sulfur centres and FAD.,384,1.0,-0.030577604,-0.029767837,-0.1331058,0.029354898,0.08257208,0.0039593047,-0.07303632,-0.03547553,0.008430852,-0.03966792,-0.034966424,-0.06458992,-0.06519961,-0.011148019,-0.03672862,0.014575849,-0.049111962,-0.0013451438,0.005065883,-0.018459942,0.07672222,0.02472485,0.018085241,-0.0050481874,-0.05639826,-0.008069309,0.023043156,-0.017436203,-0.047767837,-0.02083526,-0.0021305736,0.014513084,0.0058190846,-0.04613528,0.050995916,0.07732928,-0.006234387,-0.06861188,0.021303209,-0.052984435,0.04128828,0.05279702,0.04158411,-0.04052909,-0.07676207,-0.05529823,0.032683324,-0.02485484,0.062244236,-0.031870622,-0.07481904,-0.09059543,-0.050218586,0.045637805,0.01721381,0.03706652,0.03970457,-0.08550218,0.0021137206,-0.0029432639,0.02509692,-0.001321237,-0.0376917,-0.016784696,0.0209803,-0.012162982,-0.0024304278,-0.042743564,0.061512634,-0.07796292,-0.00085182174,0.01990196,-0.024538236,-0.03700918,-0.016798414,0.04039102,-0.023779422,-0.077700086,0.0846875,-0.025633754,-0.02262752,0.0525,0.12001511,0.08354501,0.038995884,0.03616118,0.039992724,0.015419824,-0.020651054,0.010371044,0.07069641,-0.041533362,-0.065061554,-0.06430514,-0.029632347,-0.00950593,0.04703241,0.08674517,-0.0482591,-0.009332554,-0.020606618,0.005272554,-0.033121027,-0.107304856,-0.057345167,-0.013172348,0.03467135,0.13810582,0.060548607,0.0679537,-0.022576926,-0.047496025,0.06416507,-0.00021099525,-0.023329904,0.046340156,0.08471791,-0.062157106,-0.03447755,0.051492322,0.02688032,0.012907215,0.0959656,0.02213,0.031125316,-0.01531842,-0.14163049,-2.079028e-34,0.071248025,0.018383611,0.013822227,-0.060945608,0.025846817,-0.038966555,-0.10215492,-0.018997194,0.035639107,0.017947843,-0.14058425,-0.03929085,-0.048112582,-0.029897725,-0.0402438,-0.022588978,-0.0016619734,-0.049473196,0.018431477,-0.04271078,0.025867363,0.06292153,-0.019017613,-0.024808506,0.008624251,-0.0005102543,-0.034121353,0.060570836,-0.046290934,0.02753022,0.06510915,-0.14081858,-0.12936813,0.043653324,0.055006735,0.1126762,-0.013674195,-0.051408175,-0.07494098,-0.0071298024,0.04566686,-0.001992465,0.029606055,-0.0024159362,0.04708915,-0.043833144,-0.071888566,0.059384886,0.049772065,0.011732328,-0.029270817,0.043771446,0.054437015,-0.0051657506,-0.10181447,-0.012830552,0.019510217,-0.020911679,0.08466357,0.072502,0.028965631,0.040768147,0.024060871,0.10949411,0.0009559174,0.018762305,-0.045249466,0.005352239,0.07433431,0.1126297,-0.06469617,0.0024070924,0.048015498,0.047190364,0.008260689,-0.043800194,0.030130865,-0.059350036,0.011836192,-0.01557506,-0.0046113264,-0.09769427,-0.042989206,0.033662,-0.047356386,0.05076578,-0.02958398,0.04936163,-0.0070006717,0.0018295655,0.05316916,-0.059846327,-0.023445006,0.03242754,-0.04215179,-9.785467e-34,0.008119923,-0.06762024,0.09763343,-0.12200871,-0.094233446,0.098096475,-0.011380906,0.00077954686,0.05153923,0.0074708792,0.090713084,0.005882472,0.035884134,-0.06791419,0.058124673,0.064931095,0.021571886,0.017460644,0.08733551,-0.006058355,-0.054119453,0.07752591,-0.08368379,-0.06995461,0.033199303,-0.019014215,0.05395899,0.011740072,0.058682185,0.05805762,0.021154355,0.031580552,-0.04373299,-0.06761119,-0.08778098,-0.070494995,-0.01308275,-0.061630614,-0.00406033,0.012471058,0.042161427,-0.008201006,0.029278748,0.14173739,0.071120836,0.021581607,-0.111688234,-0.013011801,0.0069579384,-0.021102615,0.046999812,-0.07236042,0.009126843,-0.045004427,0.0510171,0.037105456,-0.010441948,0.059688363,-0.05130293,-0.01146249,-0.021569187,-0.03339368,0.038366582,-0.003581979,0.04142377,0.030505,-0.028214587,0.026237058,-0.04772872,0.058420114,0.07198137,0.06403352,-0.007016795,0.05799033,0.0047612195,-0.018969906,-0.013333065,0.082607634,0.027457507,0.02171159,0.028927073,0.03918414,-0.0049855164,-0.04088949,0.048191063,-0.0511821,0.05274358,0.07519435,-0.0034167112,-0.015586421,-0.0062356815,-0.01049615,-0.05250777,-0.03861386,-0.008703112,-2.3144839e-08,0.01176027,-0.03468495,0.024064258,-0.01636483,-0.047238257,0.00752258,0.09182162,0.021039942,-0.04192752,0.017935421,-0.0147700505,0.15048555,0.0025942563,-0.029201435,-0.012690569,0.05298796,-0.030493138,0.06455034,-0.0069549335,0.04793158,0.0062876134,0.026491644,-0.016614258,0.029724112,0.003495909,-0.045961376,0.019754844,-0.02650128,-0.03935152,-0.035865378,-0.012541809,-0.006584574,0.041289542,-0.03201592,-0.120214336,0.035437334,-0.02566766,-0.03711224,-0.07912122,0.0033941946,0.041293006,-0.06553625,0.027161676,-0.028749464,-0.022589725,-0.037545845,-0.011113398,0.072009794,-0.007266397,-0.002593531,0.07539669,0.028783994,0.08518342,-0.059233382,-0.07491908,0.009983402,0.036533177,-0.08590214,-0.014498324,0.0044898144,0.11837066,-0.016095279,0.07378854,-0.034479912 +1.13.11.77,"Binds Fe2+. The enzyme isolated from the bacterium Pseudomonas sp. 42A2 has similar activity with all the three Delta9 fatty acids. cf. EC 1.13.11.62, linoleate 10R-lipoxygenase.",384,0.99999994,-0.08398382,-0.11117428,-0.119573474,0.058136515,0.07473621,0.1201321,-0.07489712,0.03360522,-0.029707136,-0.112429686,0.0330717,-0.07279363,-0.055778332,0.035615046,0.029408159,-0.037759338,-0.050789386,-0.027046826,0.012365192,0.014596942,0.07367988,0.06392276,-0.04575695,-0.025659524,-0.051198874,0.081792615,0.09531367,-0.045266423,0.011636578,-0.072109826,-0.050135706,-0.06873571,0.08320727,-0.06436929,-0.010641822,0.018684657,0.008272285,-0.014236966,0.065428786,0.003832407,0.015157565,-0.04308613,0.04484776,-0.08963771,-0.04649763,-0.04741622,0.050965622,0.009140178,0.054732244,-0.0032059744,-0.07268396,-0.03885289,-0.029059066,0.054630347,0.018768212,0.019011838,0.062413525,-0.051833227,-0.08253034,-0.0120897535,0.03741616,0.01133242,0.023055,0.081454575,-0.022329472,-0.049671855,0.06886178,-0.06632231,0.001753701,-0.037547488,-0.06507456,-0.025896804,0.011088527,0.0011369222,0.013967638,0.013516,0.011612875,-0.058772422,0.076758444,-0.08497467,-0.008581405,-0.068942495,0.026892902,0.10165222,-0.03843009,-0.01916223,-0.025985975,0.010139555,-0.0044508553,0.04468727,0.01615771,0.03584408,-0.012930149,-0.029645352,-0.03485048,0.075281166,-0.0063787582,0.067732945,-0.0054598628,-0.03671875,-0.021327883,0.07959818,-0.050632086,-0.06686439,0.037926745,0.0039078365,-0.04415824,0.028283466,-0.0139855435,0.03730506,0.088276975,-0.023847561,0.052320063,-0.0073858276,0.011672095,0.0018703458,0.08383923,-0.0788601,-0.074532405,-0.029080674,0.021603448,-0.06332781,0.028500004,0.04718681,-0.020277409,0.012570822,-0.14531583,5.3661804e-34,0.08808034,-0.036375426,-0.017859174,-0.011279172,0.009972873,-0.012576779,-0.082180485,-0.035404515,-0.06811685,0.025758175,0.009472393,-0.02407117,0.063987456,0.028234363,-0.03733163,-0.035130993,0.013393164,0.012125477,0.08632646,-0.011069013,0.029611425,0.100741714,0.021606319,-0.044001725,0.09633003,0.09956964,-0.03128856,0.0042809737,0.0021419716,-0.0013271727,0.04431272,-0.064966306,-0.1202888,-0.010489986,0.1380163,-0.042605557,0.022359665,-0.023728414,-0.08656036,-0.02448777,0.08294038,0.06154258,-0.023218432,-0.055614654,0.06084636,-0.075440586,-0.053919338,0.14828943,0.07695228,0.083922625,0.0034319295,-0.039315816,0.064346194,0.023353305,-0.046699423,-0.021594245,-0.051284328,0.06246277,0.017581189,0.08825469,0.025619788,0.07037718,-0.03956006,0.04606507,0.06089953,0.0060463715,-0.034523416,0.012622824,0.036654536,0.07017997,0.007264181,0.051119026,0.09684384,0.029389044,0.014603068,-0.06591558,-0.069723085,-0.0470774,0.04229395,0.022199227,0.03805918,-0.054334197,0.062172376,0.004971439,-0.123919114,0.0064661712,-0.06550156,-0.009148817,-0.027787557,-0.030671583,-0.009614271,-0.016700797,-0.036398947,0.055445068,-0.014712355,-2.7814257e-33,0.039231542,-0.06841967,0.064820886,-0.06626062,-0.06577389,0.054544367,-0.006799925,-0.022794029,0.0061059287,-0.003426482,0.097853094,0.043794885,0.076838955,-0.08888237,0.031176845,0.07259483,-0.036787372,0.008906181,-0.021951333,-0.029325092,0.03621659,0.00019353158,-0.04024194,0.1118004,0.068772696,0.017091325,-0.042927742,0.10435031,-0.053481143,0.06362441,0.03281328,0.035267424,-0.068159044,-0.12502788,-0.07648138,-0.064807676,-0.046090472,0.018862046,0.06919606,-0.018507328,0.026232725,0.018020699,0.014812701,0.03029,0.019880665,0.03584875,-0.04774969,-0.023763068,-0.0139174145,-0.02173608,-0.065719426,-0.06537365,-0.035551462,0.027051495,0.030851545,0.04180378,0.019422168,0.07616588,0.029001055,-0.038335446,-0.011092875,-0.054261155,0.014210682,0.012320327,0.014361145,0.054258503,0.018258287,0.011887735,-0.0070611895,-0.0020417722,0.031827822,0.030286696,0.024189835,0.036418214,-0.037956703,-0.02529509,-0.013084153,-0.058249287,0.0051807803,0.07233788,0.07119785,0.0014513087,-0.015047974,-0.09024076,0.02709897,0.009672014,0.019664206,0.048953556,0.008629632,-0.013731073,-0.023790935,0.009712223,-0.04366144,-0.05631663,-0.00878553,-3.2469973e-08,0.0020111136,-0.05625427,0.08710713,-0.048474718,-0.06515883,0.012779839,-0.011993073,-0.020927917,0.011725017,-0.03431115,0.0054549826,0.05438945,0.01747887,0.052190375,0.061770245,-0.020578954,-0.035048634,-0.012887951,-0.044506792,-0.060205717,-0.060164392,-0.05835241,-0.047796108,0.0147004,0.005883857,-0.062075038,-0.033628125,-0.035556376,0.05447229,0.00863705,-0.06666078,0.0058348286,-0.030784192,-0.0364224,-0.037673675,-0.0041348753,0.022049092,-0.05243377,-0.053618506,0.09946702,0.07105369,-0.060271587,-0.08183863,-0.03006668,0.041268073,0.04066883,-0.025545701,0.04589836,-0.018534752,-0.04669801,0.08541673,-0.013930479,0.020152465,0.003617452,-0.07103056,0.0014958202,-0.028746737,-0.0011496135,0.018245915,0.060736027,-0.015945897,0.008660855,0.11006295,0.0054750373 +1.14.13.183,A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from ginseng (Panax ginseng).,384,1.0,-0.055314947,-0.009241568,-0.047270857,-0.0023835814,0.04065394,0.046282824,0.0009792795,0.13178438,0.07880504,0.06317265,-0.062142763,0.064333916,-0.03811692,0.050322905,-0.0295036,-0.0017637343,-0.078459695,0.058380544,-0.032622848,-0.062472396,0.04392394,0.040890243,0.059834454,0.019061634,0.05022266,0.018268984,0.08081268,-0.0066154795,-0.010973832,0.06077507,-0.053228214,-0.020206533,0.020377414,-0.06746554,-0.025302438,0.08393518,-0.0689996,-0.07070756,0.0862868,-0.07973072,0.13197407,0.030417724,-0.008405958,-0.004282549,0.02827737,0.0022887408,-0.042137437,0.0456409,0.02241654,0.09463067,0.015845213,-0.03372131,0.009148284,-0.0015469341,-0.02123038,-0.03251434,0.015469757,0.000705489,0.07122439,0.05784286,0.046298318,0.0046231663,-0.08550178,0.06215582,-0.04660428,-0.03347596,0.055302978,0.104634054,-0.010250019,-0.050282396,0.016841682,-0.04964249,0.02987023,0.044320848,0.026543194,0.012987132,0.010979491,0.030313877,-0.04622496,-0.019728811,0.04653942,0.029508611,0.037318658,0.1648712,5.5240154e-05,0.013890653,-0.017869744,0.11225911,-0.026862124,-0.09012036,-0.03952817,-0.003150565,-0.025750391,0.014420435,0.006817008,0.013597475,0.013664662,0.028048992,0.006281169,-0.009471139,0.011600946,0.06682167,-0.003048646,-0.100040704,-0.02733386,0.05930932,-0.084197275,0.016968679,0.086825095,-0.01708756,0.0141270915,0.013457468,0.04190324,-0.039714355,-0.03336869,0.04360486,-0.03041762,-0.018744646,0.030646538,-0.020773696,-0.01547426,-0.053214822,0.052518763,-0.012611271,-0.07881644,-0.041171115,-0.006850342,-4.4711865e-34,-0.0009474103,-0.026575256,0.0811941,0.0065729334,-0.034543578,0.027512407,-0.022950185,-0.04433107,-0.05272372,0.036979456,-0.089501545,-0.080607854,-0.033426967,-0.066412374,-0.009245248,-0.014326531,-0.032014467,-0.013013799,-0.013305902,-0.016331386,-0.0460354,0.12502658,-0.090041555,0.095889874,-0.0121426005,0.03727695,0.023911582,-0.048813995,0.044859074,-0.024992496,-0.051378895,0.034113597,0.00014004945,-0.07412695,0.01805489,0.024941983,-0.058377985,-0.011676908,-0.027275585,-0.006723923,0.016791109,-0.002098516,0.005793191,-0.046084203,-0.0015620014,-0.045296587,-0.12547873,0.0073144357,-0.0005714564,0.05639105,-0.0387073,0.029362557,0.06785323,0.055897564,-0.093667775,-0.0594068,0.012114855,0.0156109445,0.024583694,0.0076933578,0.07285981,-0.037640784,-0.01962755,0.044493202,0.025412055,0.12655231,-0.066916905,0.003709771,-0.045130454,0.09755001,-0.03674793,0.021118907,-0.08827206,-0.04567854,-0.0046237884,-0.05358697,0.009870796,0.13933165,-0.024705777,0.045704007,0.018270543,-0.03215747,-0.07756261,0.020835314,-0.046782803,-0.012428563,0.02071165,0.046371546,0.01210281,0.007652049,0.050109692,-0.009316147,-0.057831593,0.06350874,-0.05423871,-5.157273e-34,0.008291116,-0.078548305,0.057614513,-0.020806026,-0.04704061,0.063710414,-0.017708784,-0.05693033,-0.06512675,0.0043675243,0.10676098,-0.016685383,0.029975984,0.0028597096,-0.067845404,0.035478782,0.0024291135,0.030396456,-0.06656322,0.10979391,0.020548962,0.07133234,0.006477277,-0.028372994,-0.008164068,0.014207903,-0.022884047,-0.034666657,0.010831835,0.07888993,0.023103999,0.026888939,-0.12300072,-0.012530312,-0.04067673,0.012745601,0.06761639,-0.042674135,-0.047194622,-0.025812548,-0.029736934,0.088807695,0.07144104,0.07623276,0.0776803,0.068855345,-0.07587883,-0.014957114,-0.116719805,0.022015417,-0.02178837,0.062923945,0.016388351,0.0071847723,-0.008249607,-0.09924187,-0.032094143,-0.04149214,0.0028515758,-0.070523575,-0.0317528,-0.023679035,0.012197814,0.03481602,0.03485278,-0.010239703,-0.13612509,0.09154415,4.424425e-05,-0.025080955,0.014538294,0.02171168,0.099291004,0.037726518,0.0012050078,0.007529902,-0.008990049,-0.06630764,0.0034041211,0.0014430498,0.0142211905,0.04899907,-0.032887463,0.021683987,-0.07170588,-0.029263863,0.005252352,0.050953694,0.056649935,0.035598215,-0.0649605,0.06514422,-0.04260432,0.026225025,0.044525377,-2.5795703e-08,-0.0373653,-0.04394834,-0.033275433,0.011784666,-0.061169915,-0.019738335,-0.074814625,0.05268035,-0.009463492,0.0058466834,0.015993897,0.006382034,-0.055573925,-0.063617416,-0.029475348,0.004028835,0.02765272,0.06614547,0.04365066,0.03542523,-0.024536163,-0.0025104994,0.041292712,0.04314802,0.042688686,-0.061672173,-0.016482346,-0.017885158,0.04477078,-0.05028399,-0.008097596,0.05189357,-0.050270624,-0.021003356,-0.009917439,0.079849474,-0.057002887,0.044763356,-0.061380193,-0.033506796,-0.031691033,-0.092760175,-0.07847124,5.7818877e-05,-0.06770084,-0.025173463,0.12314871,0.057813555,-0.014335328,-0.010956764,-0.07109357,-0.016745906,0.015392535,-0.09883536,-0.068020806,-0.05040833,0.06039567,0.024220834,0.019585518,-0.11539226,-0.04718354,-0.044715904,0.13048556,0.031556025 +1.14.13.184,A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from the rhizomes of ginseng (Panax ginseng).,384,1.0,-0.0517735,-0.024798444,-0.07054622,-0.0061220075,0.04709378,0.04858876,-0.00044052524,0.1381011,0.06831422,0.06678126,-0.056365468,0.060495894,-0.03439253,0.08149284,-0.04294368,-0.007594273,-0.08548939,0.079810284,-0.055214368,-0.042371493,0.042283982,0.05469219,0.06415637,0.022225402,0.06846145,0.021956015,0.096627936,-0.006149055,-0.019949462,0.047980864,-0.042116817,-0.028275182,0.0342029,-0.08822492,-0.012274922,0.087183446,-0.061427422,-0.056007635,0.094782904,-0.07683761,0.10922672,0.0424073,0.031645473,-0.013394325,0.03449455,0.007837794,-0.048240732,0.054027505,0.04272182,0.07327663,0.000781637,-0.025826674,0.011270135,0.0367364,-0.026955081,-0.031218518,0.019735003,-0.0107768625,0.03556064,0.056701045,0.044214047,-0.008722536,-0.09928623,0.055391606,-0.069435,-0.03296931,0.04044595,0.113625795,-0.004885273,-0.024355981,0.013783695,-0.049106285,0.029600827,0.025675451,0.033978365,0.022852506,0.025747182,0.041846346,-0.075682364,-0.027285386,0.044930354,0.012442531,0.051785786,0.14709657,-0.00607732,0.036048792,-0.0022363844,0.09985492,-5.3469008e-05,-0.09102855,-0.028571801,0.015407332,-0.008400407,-0.0016971733,-0.002849722,0.0095275035,0.020208493,0.040929273,0.018790944,-0.017694091,0.041612577,0.047403216,-0.0020821926,-0.100250944,-0.02518817,0.06806915,-0.096914984,0.029997597,0.07401537,-0.02700808,0.01599377,0.0189241,0.05102229,-0.03138572,-0.034649752,0.0331725,-0.025455633,-0.012362776,0.013441292,-0.012145455,-0.018920848,-0.052138753,0.055068873,-0.05637477,-0.05340042,-0.04057395,-0.036923904,-5.438228e-35,-0.003098803,0.0015748285,0.058389917,-0.0059425295,-0.024582526,0.051680412,-0.0428134,-0.036248963,-0.06481266,0.0036970796,-0.097722806,-0.058569483,-0.03944447,-0.08685781,-0.032117352,0.0106089115,-0.045021553,-0.019804683,-0.016933909,-0.010663012,-0.034769025,0.109812565,-0.10412391,0.09165216,-0.02471784,0.026826305,0.04145143,-0.05617171,0.008347717,-0.024102008,-0.05283587,0.049506936,-0.020542102,-0.047593888,0.031901665,0.028265629,-0.05666713,-0.013600136,-0.015767593,-0.025725672,0.03158986,-0.003725114,-0.024051007,-0.029597834,0.0044545587,-0.05571795,-0.13388166,0.0222661,0.011082384,0.08164108,-0.04027018,0.028222928,0.079500124,0.07384405,-0.09696247,-0.07839325,-0.007881354,0.01996729,0.046922598,-0.0017325854,0.056407165,-0.046602778,-0.02126924,0.049420815,0.023117997,0.11155358,-0.056848757,-0.0033586626,-0.03570523,0.09964665,-0.032715447,-0.0005792411,-0.08338849,-0.022357065,-0.0012777046,-0.070029505,0.003253063,0.13337602,-0.015593615,0.069062665,0.025520055,-0.03768932,-0.09451343,0.014749181,-0.0647131,-0.005319852,0.028634125,0.044874594,0.0054792436,0.0045708977,0.07818949,-0.026646776,-0.06428672,0.054436352,-0.0484982,-3.5285096e-34,0.027847413,-0.06799556,0.04756155,-0.003775184,-0.028697865,0.018861605,-0.014780933,-0.037386388,-0.056844633,-0.025009863,0.111759506,-0.013967123,0.031479817,0.03357507,-0.054281086,0.022659088,0.033389468,0.030028922,-0.04514223,0.08617895,0.005812057,0.05214403,-0.008495451,-0.018610694,-0.009281038,0.02374049,-0.02473611,-0.01933091,-0.008661933,0.08151982,0.04087076,0.053151384,-0.13156736,-0.032455597,-0.039646044,0.025778081,0.06349578,-0.03481826,-0.037097167,-0.020592052,-0.0055370834,0.085367106,0.05415739,0.078509346,0.083294675,0.055724885,-0.09302617,0.008400194,-0.11803332,0.0012297869,-0.024374079,0.054582633,0.026886215,-0.0024797309,0.0040625287,-0.08981571,-0.046682645,-0.031167367,0.0116588045,-0.03685107,-0.028571304,-0.020825453,-0.008928448,0.032763593,0.02886684,-0.017143784,-0.11025306,0.09046387,0.021135522,-0.011030867,0.013419328,0.035939366,0.123533696,0.045792002,-0.013738334,0.007959011,-0.019052505,-0.061138716,-0.010958502,-0.009626012,0.026519297,0.042269982,-0.011864083,0.028537303,-0.08639456,-0.03986127,-0.008366733,0.0458275,0.040037863,0.027274415,-0.03685611,0.063232236,-0.033441063,0.04460043,0.07331012,-2.6630813e-08,0.0013345438,-0.063307494,-0.023664357,-0.0066985916,-0.048496757,-0.0011592627,-0.06633329,0.042929534,0.00067334034,0.023414655,0.004267724,0.0061972984,-0.039131206,-0.045564845,-0.028680323,0.025767064,0.026351722,0.06831407,0.02519099,0.04126181,-0.0058619278,-0.006969673,0.01809725,0.044242486,0.038668737,-0.049478788,-0.021615818,-0.018324846,0.033262048,-0.063680366,0.0015321072,0.04531017,-0.017346714,0.0008492747,-0.021252217,0.06311694,-0.054215252,0.029068474,-0.07029044,-0.07851597,-0.023945233,-0.08705848,-0.07757401,-0.0046130875,-0.093274586,-0.042890243,0.10656555,0.046286654,-0.011606971,-0.035491128,-0.070941135,-0.003918688,0.020980636,-0.10571612,-0.06918291,-0.05264975,0.06502967,0.040097363,0.020862747,-0.11572631,-0.06654301,-0.0405634,0.1134506,0.021110449 +2.1.1.289,"This enzyme catalyses the methylation at C-5 of cobalt-precorrin-7, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway. The equivalent activity in the aerobic adenosylcobalamin biosynthesis pathway is catalysed by the bifunctional enzyme EC 2.1.1.132, precorrin-6B C5,15-methyltransferase (decarboxylating).",384,0.99999994,-0.038428705,0.05189035,-0.10578963,0.02096381,0.046092223,0.04005097,-0.1123855,-0.03071107,0.03413942,0.01754006,-0.05081592,-0.06498193,-0.072538964,-0.019878553,-0.01735389,0.04388607,-0.0760217,-0.0098057715,-0.06905981,-0.03498706,0.0065187844,0.009132245,-0.02508204,0.04240767,0.051137816,-0.026615396,0.04254032,0.030669063,-0.011297485,0.0007266932,-0.037393592,0.00433905,0.062570915,-0.008476995,-0.018643511,0.1418502,0.016941538,-0.028845137,0.07993838,0.0060795425,-0.008109354,0.014887052,-0.023143789,0.0044324463,-0.021804258,-0.027258562,0.04121527,0.03107352,0.00815141,-0.038392488,-0.009580454,-0.019758876,-0.06440761,-0.056333914,0.022587752,0.010369873,-0.053366452,-0.08669763,0.053687572,-0.00021644462,0.047769137,-0.07673833,-0.049442627,0.027372135,-0.013879266,-0.025398687,0.054455165,-0.052399777,0.048811972,-0.055342425,-0.04932407,-0.093003474,-0.001660105,0.012969038,-0.055933494,0.053574223,0.03434859,-0.053611036,0.040543616,-0.03217668,-0.019932572,0.058232766,0.021719899,0.010636373,0.062397223,-0.010365919,-0.02501319,0.027031198,0.047035184,0.07882384,-0.011604867,0.008215124,0.064658165,-0.024459966,-0.11977267,0.0044438182,0.047584675,0.038542382,0.016993534,-0.013908925,0.052086405,0.11837475,-0.056052122,-0.01545941,0.056806806,-0.047191683,0.03745084,0.1709334,0.0019821373,0.018576883,-0.0066170646,0.07114024,-0.0012249681,0.03105511,0.0036662172,0.13184404,0.026760597,-0.06595084,-0.07794232,0.050736684,0.018690484,-0.022792928,0.022353576,0.029794265,-0.06446091,-0.09159909,-0.00603392,3.638185e-33,0.057937987,-0.00908541,0.035080492,-0.004705989,-0.017705834,0.02264953,-0.1139612,0.045699768,0.031004833,-0.00874785,-0.019778332,-0.080449894,0.05218642,0.023137838,-0.09478895,-0.07477258,-0.048290666,-0.064407565,0.024020074,0.026983324,-0.04937329,0.03560265,-0.031508923,0.007786198,-0.0056705046,0.08511595,-0.011965026,0.06270476,0.0670065,-0.0011229119,-0.003375092,-0.07833148,-0.071598254,-0.06843958,0.026800124,-0.0033919543,-0.021887247,0.065416954,0.038440935,0.11826559,0.03248106,0.012071134,-0.07171104,-0.06887324,0.03951706,-0.018825008,-0.03698241,0.105440214,0.020717265,0.04205975,-0.005461701,0.016296534,0.07761509,0.0006351437,-0.035418082,0.0213751,0.01779943,-0.022211308,-0.009972116,0.07178746,0.08331722,-0.0071075032,-0.023682488,0.054438878,-0.035250563,-0.04898797,-0.058620054,-0.05760026,0.024245616,0.025749084,-0.022208236,-0.008478007,0.072515726,0.039757434,0.030947432,0.011562851,-0.07335214,-0.031333603,0.0076163113,-0.010947143,-0.050664872,0.06690686,-0.023890778,-0.0490219,-0.06307504,0.06105769,-0.02103988,-0.072463565,-0.0027592343,-0.017892852,-0.03941142,-0.03458484,-0.048187096,0.0007900437,0.036430385,-4.991177e-33,0.13865657,-0.10418026,0.064645626,-0.113600366,-0.022528758,0.068679586,0.053801764,-0.1009399,-0.038117073,-0.005428718,0.09376352,0.011733362,0.039638683,0.019919142,0.04105331,0.017333195,-0.018620672,0.106528856,-0.0008558928,0.035248134,0.005018198,0.00802922,-0.03781804,0.039083805,0.019425096,0.046746794,-0.008276089,0.005554067,0.08690655,0.079534896,-0.058429465,0.025612606,-0.008531636,-0.014338035,-0.0020987776,0.09458965,-0.03942218,0.027987018,-0.043846436,-0.009407279,-0.004197325,0.022194609,-0.072379835,0.02059198,0.036559325,0.04782283,-0.05150578,0.046485133,-0.036828224,-0.022817448,0.062256265,0.017191589,-0.068766184,0.046179235,0.06630932,0.04296213,0.03507504,-0.050912913,0.07616789,-0.09233248,-0.084504716,-0.017370047,0.026429925,-0.08913409,0.049459524,0.002430212,-0.0061219097,0.08393865,0.024254655,0.0043622274,0.04747272,0.031751268,-0.0036255987,-0.01298142,-0.086279824,-0.03226475,0.006692082,-0.05689396,-0.05626334,-0.04090005,-0.04218997,-0.002309149,0.034412872,-0.051483344,-0.09327352,-0.029035775,0.082317,0.03791641,-0.061015017,0.05474952,-0.062033374,-0.033908773,-0.047778443,0.0051851794,0.01776986,-3.641159e-08,-0.00195673,-0.117406026,0.059136678,0.005276939,-0.010395733,0.11967346,-0.037139732,-0.02992968,0.06005523,-0.0076103765,0.05496056,0.060476128,0.037565798,0.019158268,-0.105535135,0.007388206,-0.061691746,0.016267404,0.04957474,0.0050567393,-0.082159795,0.023698598,-0.03213389,-0.058946934,0.07568899,-0.10451631,-0.0683703,0.083212085,0.024340177,-0.023461482,0.009809875,0.03379148,0.060514983,-0.05429201,0.0064828694,0.0016061114,-0.012590707,-0.033244666,-0.0461792,-0.014296577,-0.02447085,-0.06359885,-0.081391096,0.02156022,-3.0686657e-05,-0.013912854,-0.008531186,0.077387646,-0.027598849,-0.015081823,0.05693928,-0.028754039,0.012792415,-0.015942642,-0.024706684,0.04164767,-0.06559987,-0.099321775,-0.044123758,0.008860271,0.015510682,0.035967268,0.07577863,-0.13632508 +2.1.1.290,"The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.3.1.231, tRNAPhe 7-[(3S)-4-methoxy-(3-amino-3-carboxypropyl)wyosine37-O]-carbonyltransferase [2].",384,1.0,-0.0063611213,-0.051210087,-0.10511323,-0.023359714,0.037964143,-0.0040434366,-0.0343153,0.028399136,-0.009721202,-0.0007525063,0.027448209,-0.06297619,-0.018854827,0.048676077,-0.057705767,0.0032122345,-0.10696138,-0.041618373,0.041315705,-0.06741472,0.052381113,0.091332965,0.029037314,0.03699416,-1.4880651e-05,-0.03577629,0.049972862,0.0020347054,0.0033079102,-0.07672678,-0.020642105,-0.054306366,0.028728558,-0.026876574,0.046834897,0.0780225,-0.066837184,-0.088408574,0.06651392,-0.0025095236,0.021396056,-0.0023730982,-0.0077014617,-0.02059736,-0.033896983,-0.024201816,0.03513193,0.01443013,0.005072822,0.033678725,-0.01800722,-0.105222486,0.009176531,0.06051212,-0.008187396,-0.013413543,-0.018724162,0.037091937,0.021512628,0.020933885,0.030392677,0.03131582,0.047912348,-0.041925307,-0.005457416,-0.049260102,0.02748714,-0.037833005,0.022849567,-0.06321596,-0.033602007,-0.044649012,-0.00014487031,0.110270165,-0.027759202,0.026364485,0.00446239,-0.03042811,0.0130155925,0.0009876649,0.022828452,-0.045879938,0.05537148,0.073821746,0.046437956,-0.019434484,-0.06990559,0.0336342,0.017844476,0.044767033,0.03426266,-0.0426871,0.01942365,0.0074215815,-0.048419334,0.033473972,0.08290502,0.12987295,0.03248666,-0.04980732,0.009361832,0.022896037,0.0022069337,-0.03896073,0.01989311,0.005419417,0.03916523,0.09633224,-0.0013649311,-0.0513892,-0.06375898,0.022718294,0.043971457,-0.0014397466,-0.041838076,0.07610923,0.051039204,-0.00067954935,-0.014629555,-0.004094679,0.025307108,0.036740135,0.13193902,0.031330723,-0.08780394,0.0349796,-0.073804915,2.8880162e-33,0.03641352,0.0104357265,-0.012367349,0.012989834,0.011561177,-0.0007534957,-0.051736053,-0.0007296672,-0.046172425,-0.08755848,-0.13436508,-0.02866653,0.0742983,0.013332985,0.016062925,-0.02742624,-0.03784941,-0.022149226,0.015429507,0.05874915,0.03342121,-0.0030905406,-0.09087145,0.07624944,-0.037327297,0.0153196035,0.0068422216,0.09663886,0.055251177,0.012329793,-0.057152443,-0.097318955,-0.0488862,-0.027863532,0.09197008,-0.015840527,-0.03167461,-0.028723989,-0.025805198,0.020552827,0.08241111,-0.03965303,0.033272427,-0.07461878,0.07066595,-0.008682863,-0.012341061,0.071748346,-0.0057590753,0.040377885,0.04063737,-0.019147137,0.04433368,0.0031126589,-0.0326249,0.057769377,0.027981617,-0.039178934,0.117638536,0.056767296,-0.0354652,0.053772956,0.03554918,0.024921594,-0.045577176,0.016834589,-0.1025442,-0.05816923,-0.11311852,0.052059956,-0.04479648,-0.07645038,0.09032576,0.02910156,0.084165074,-0.050205234,-0.05773216,-0.029950866,-0.01379731,-0.010606628,0.040600378,0.0001472469,0.049039315,-0.03276262,0.025284266,-0.01860511,0.006518228,-0.056055088,-0.044933178,0.08922273,-0.004403048,-0.06255852,-0.0934026,0.012029079,-0.004864938,-3.4951943e-33,0.046897758,-0.017893879,0.049647994,-0.07224347,-0.08122612,0.016608968,0.016331283,-0.07353848,0.05161226,-0.0647392,0.11821936,-0.0310823,-0.043996505,-0.002892633,0.057960093,0.0136009315,0.001218955,0.0014542253,0.011091104,-0.019792635,0.052959703,-0.027888425,-0.04330213,0.013255169,0.0089999605,-0.028122365,-0.028137475,0.035028398,0.05898127,0.07751618,-0.15022983,-0.03197596,0.0060269292,0.04642479,-0.051321395,0.026291175,-0.06289633,-0.057663307,0.049357116,0.010156818,0.0025334868,-0.0001195472,-0.02257038,0.063689776,0.013368318,0.16016531,-0.056104053,-0.010065186,-0.05266465,-0.01809734,0.07644893,0.016508436,0.03969241,0.031610213,0.0098197,0.021479787,-0.05527839,0.058342837,0.04013269,-0.025043897,0.01080962,-0.0589322,-0.0067258663,0.013580223,0.009209937,0.02234658,-0.091095895,0.09574988,0.00016363821,-0.044123527,0.0323373,-0.00053568714,0.01386755,0.036528997,-0.015927609,-0.050953586,-0.08526737,-0.049882144,-0.024194326,-0.065837145,0.030493211,0.018920548,0.05332501,-0.11328743,0.026123807,-0.059394922,0.0068446617,0.12148844,-0.023477796,0.07999802,-0.037991475,0.027965307,-0.04888203,-0.0037471708,0.10542559,-4.654384e-08,-0.076179385,-0.03149766,0.02545195,-0.04194411,0.013847136,0.02021894,0.013227187,0.04035483,0.05941597,-0.02127041,-0.024803108,0.032286905,-0.04001219,0.031946227,-0.019182382,0.054662768,-0.05247212,0.035254747,0.032533687,0.049682382,-0.011266385,0.035458602,-0.071324006,0.07150159,0.0076860045,-0.0020945584,0.05531496,0.07360785,-0.04912732,-0.086852886,-0.038204256,0.007814819,-0.017578056,-0.010179989,-0.09336996,0.00396043,-0.10019077,-0.012690512,-0.09843306,0.0702214,0.015511797,-0.0003010146,-0.06251213,0.022514746,0.01647658,0.0073463577,-0.028257946,0.115704924,-0.0037969195,-0.05064247,0.09158137,-0.04529388,0.02169189,-0.06840685,-0.06157353,-0.011149827,-0.008209967,-0.0692801,-0.07370354,-0.025023406,-0.05264553,0.03091746,0.205992,-0.03558365 +2.1.1.291,The enzyme from the plant Papaver somniferum (opium poppy) methylates (S)- and (R)-reticuline with equal efficiency and is involved in the biosynthesis of tetrahydrobenzylisoquinoline alkaloids.,384,1.0,0.050442263,-0.004906302,-0.15193748,-0.0033493033,0.036571085,0.13542667,-0.07933631,0.045524783,0.028688997,-0.06404707,0.016269313,0.019760886,0.013588024,-0.059315693,-0.020588446,0.018724881,-0.06784583,0.033743042,0.005793525,-0.05689262,0.043687545,-0.011799683,0.029089084,0.051884912,-0.0039949673,0.06268144,-0.092048936,0.0019085644,0.05057163,-0.055584878,0.05222161,0.08541656,-0.05045816,-0.043542434,-0.042286694,0.077446885,-0.05350894,-0.005996158,0.060634393,0.054141946,0.07039952,-0.034870736,-0.06339329,-0.00020039991,-0.03516561,0.003276541,-0.009309369,0.04086326,0.00059231825,-0.047236215,-0.014452023,-0.057536773,-0.06677972,0.095304675,0.017066892,-0.023185521,0.06086245,0.080715604,-0.030478008,0.059948415,0.0025098047,0.06458667,0.02163105,0.020202402,0.02169086,-0.026313383,-0.07661238,-0.0037139957,0.08240578,-0.053951006,-0.018249469,-0.06772311,-0.0005312967,0.04674508,-0.065309905,0.03356132,-0.039954558,0.03058585,-0.011878316,-0.027359148,0.10860707,-0.0016955914,-0.034457173,0.07259472,0.005744441,-0.03240527,-0.054295987,0.049448453,0.122471675,0.010942381,0.10661373,-0.007823821,-0.07547854,-0.0059751696,-0.06803999,0.002149262,0.052432444,-0.007020367,-0.033039365,-0.04571265,0.027680574,2.8479497e-05,-0.09956437,-0.06955428,-0.022682115,0.02715289,-0.061596584,0.001204729,-0.009492304,0.024749398,-0.025058135,-0.058122918,-0.013003986,-0.0010089548,-0.07318578,0.029498754,0.046868987,-0.055711184,-0.0371911,-0.08643093,-0.030889895,0.024668518,0.069980085,0.017338486,0.032522213,-0.03373336,-0.10680071,2.1788192e-33,0.017731676,0.10093414,-0.016534325,-0.03110196,0.021876879,-0.0897903,0.04521967,0.04529936,0.051525865,-0.06575655,-0.096197605,-0.049015466,-0.042108543,0.010317733,0.022975685,-0.034018096,-0.0299935,-0.058389917,0.011905376,-0.04758144,-0.071252726,0.0502296,-0.09363719,0.0139046535,0.021553008,0.08891719,-0.01892149,-0.009327405,0.016653737,-0.036529236,0.049035326,-0.038869638,-0.08892865,-0.008635792,0.092131644,0.0038924695,-0.031782407,-0.012162004,-0.044095848,0.016939422,0.012153877,0.03484564,0.06435569,0.020200178,0.016827365,-0.005318608,-0.085679315,0.05912894,0.10863207,0.01444288,0.035045747,0.0081488155,0.011027065,0.013927869,-0.0987627,0.042108815,-0.047205053,0.024769628,-0.037802316,0.041553363,-0.034542635,-0.06321342,-0.0077972785,0.036179543,0.055154514,-0.029085914,-0.058652673,-0.020522505,0.021915132,0.07486788,-0.068359226,-0.010843946,0.06356277,-0.013051223,0.022226457,0.01998096,-0.013661459,0.0036109607,0.0398163,-0.03263174,0.014820872,-0.026037425,0.014473554,0.0003412758,-0.057841077,-0.005571603,0.054156065,0.0024556308,-0.009835396,0.054778125,0.00026618276,-0.024732336,0.0007117302,-0.007853707,-0.016281545,-3.4545336e-33,0.041828178,-0.042641107,0.07828762,-0.004114633,-0.008311039,0.083956316,-0.04324702,0.046427105,-0.0022664955,0.09043071,0.012564276,-0.016387764,0.09556736,0.010328211,-0.019649789,-0.035545137,0.0007581004,0.14512028,-0.013206898,-0.021907767,-0.09105883,0.09474251,-0.04508829,0.040922966,-0.012494204,0.015371483,0.01925561,0.004985347,0.04017434,0.056527954,0.06843644,-0.052700955,-0.08714737,-0.006777663,0.00044984245,0.122769915,0.0151490765,0.028206384,-0.021749211,0.07214228,0.019070704,-0.00022234571,0.020169552,0.017154204,0.03427258,-0.029849505,-0.12391126,0.07840441,0.030600421,-0.03140055,0.04680021,-0.005199816,-0.04648446,0.008212318,-0.018286254,-0.037166756,0.0074248603,-0.061944127,-0.043990158,-0.08074162,0.011236852,-0.035501,-0.077160984,-0.08340975,-0.01636439,0.02037997,0.010849987,0.00882604,0.07562037,0.012508764,0.06513668,0.014904641,0.022924654,0.094291694,-0.038183153,-0.071187474,-0.059697136,-0.05545674,0.014566771,-0.043638017,0.055181343,0.01731985,0.035554897,-0.044740595,0.004430341,0.012704097,0.014628822,0.1327368,0.019381016,-0.022902993,0.035639204,-0.02700407,-0.07744959,0.08730092,0.06856831,-3.453164e-08,0.030408219,-0.07070153,0.037354037,0.0037573932,-0.011982627,0.007857761,0.014455239,-0.05944137,0.01682593,-0.048099276,0.0017913976,0.018690627,-0.038114674,0.054837856,0.024780791,-0.03463465,-0.02721861,0.09359934,-0.016226722,0.0077374578,-0.068406284,-0.00020587051,-0.060111105,-0.0555088,0.06071774,-0.008757915,0.016316457,0.048209213,0.019704137,0.062412698,0.06418206,-0.0071756756,0.0022608163,-0.003856869,-0.058937848,0.04303443,0.029971665,-0.03772212,0.026722867,-0.01642736,-0.008450601,-0.056287427,-0.04544987,0.050222464,-0.02965473,-0.07137617,0.008634406,0.0035578096,0.015417503,-0.019200275,0.024262886,-0.020411545,0.028217837,-0.13186976,-0.09123116,-0.058207817,-0.0680553,-0.016752394,-0.0132098235,-0.1588091,0.0067478563,0.008884431,0.21841542,0.0018926716 +2.1.1.292,"The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. In vitro the enzyme from Streptomyces sp. C5 also catalyses the 4-O-methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy-13-deoxycarminomycin [3]. 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+2.1.1.293,"Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.",384,1.0,0.043305136,-0.04391303,-0.02738937,0.013718078,-0.059433796,0.1313912,-0.06464466,0.035479147,0.07832151,0.021275725,-0.015184554,-0.08337065,-0.02431658,0.035616525,-0.06690964,0.025752999,-0.016886903,0.05618368,0.0089608915,-0.067183435,-0.039212056,0.05019453,0.10893718,-0.05828498,-0.0028886155,0.022254005,-0.088783905,0.03150988,0.012240639,-0.021932438,0.008650101,-0.026931414,-0.069106355,-0.0060709957,0.001138623,0.04993785,-0.13604704,0.045694083,0.12256282,0.02508414,-0.044183236,-0.056652576,-0.10881591,0.011503084,-0.033844076,-0.019816311,-0.005586392,-0.008556745,0.05326481,0.034297287,-0.02468166,0.019244984,0.010613194,0.0629569,0.1137651,-0.015360789,0.055382174,0.09557731,-0.0035981038,0.07951096,0.03351841,0.036189433,-0.011211778,-0.048207887,-0.048275564,-0.049463984,-0.060977403,0.0095919985,0.029204862,0.00014173923,0.010596982,-0.05020596,0.016340164,0.033148907,-0.01989809,0.08969294,-0.034202557,-0.033239976,-0.12443569,-0.07106252,0.0924759,-0.0075049675,0.006653421,0.075815216,-0.06918259,-0.022921324,-0.018147359,0.036699697,0.02026238,0.025213333,0.07476298,0.006807371,-0.024863463,-0.060282804,0.05401487,-0.003605834,-0.0059930147,0.007997166,0.0070435135,-0.04454683,0.019556552,-0.044183064,-0.06825637,-0.08814867,0.007588588,-0.012807487,-0.058951885,-0.050924495,0.032940794,-0.05247795,-0.0055053136,0.009846707,0.091321394,0.040102243,-0.04554126,0.032660346,-0.034422085,-0.027254315,-0.0132335005,0.0029012559,0.00049343234,0.020443104,0.05772786,0.112274565,-0.037490517,-0.044535674,-0.0111812,1.9170788e-33,0.1106158,0.01944499,-0.04097553,0.074061036,0.007567765,-0.050905216,-0.05568679,-0.03955443,0.0052548787,-0.0038376031,-0.0841935,-0.04676142,0.031699453,0.013943372,0.029970372,-0.017384568,-0.08452016,-0.059486825,0.019908788,-0.063615605,-0.05604553,0.008282924,-0.051283363,-0.036355503,-0.10295224,0.061007455,0.02542374,0.08551387,0.011696797,-0.049639646,-0.016856864,-0.028804272,-0.01328906,0.021417588,-0.02648501,-0.0061866087,0.027612051,0.01465843,-0.06183146,-0.006555266,0.053131465,0.11534156,-0.03379299,0.026835898,0.0991735,0.050018255,-0.06642959,0.10632715,0.073230065,0.09253502,0.06239692,-0.06792594,0.07030854,0.027486082,-0.05641887,0.0135728195,-0.018616816,-0.018959474,-0.010505041,0.0638695,-0.08181761,-0.06269005,-0.006857891,-0.014512667,0.005749221,-0.011848225,-0.015880985,-0.10435898,-0.024897857,0.051798075,-0.040124726,0.019615473,0.048836287,0.0066649,0.002146997,0.03331739,-0.0064641703,-0.0024365888,-0.05068283,0.012163385,0.011364815,0.010389765,-0.02492316,0.043962747,0.019397026,-0.06786308,-0.04059912,-0.07476034,0.028899575,0.0124487635,-0.032087028,-0.0615851,-0.08244968,0.09434885,0.002357046,-3.596914e-33,0.04592317,-0.08322108,0.034824137,-0.013897361,-0.022306599,0.053771216,-0.028453946,0.023436505,0.023995562,0.04270028,0.09043903,-0.051969405,0.11259225,0.036215052,-0.09472597,-0.1126373,-0.00043533763,0.082639426,-0.01024886,0.07736638,-0.06274484,0.027269673,-0.037927732,0.035436783,0.05219028,0.10276131,0.008277019,-0.009319624,-0.11701848,0.046634305,0.118794166,-0.049782585,-0.14304091,-0.02841782,0.07768013,0.04655994,0.00085461704,-0.00030748948,-0.0063080704,0.0047160224,0.02241541,0.07149358,0.053381357,0.0018244833,0.025104579,0.0057685394,-0.07493612,0.008413257,-0.014940081,-0.077337466,0.0077991737,-0.009913778,-0.007869058,-0.017360272,0.00814407,-0.00014866886,0.03965001,-0.036636155,0.07776831,-0.01298872,-0.040921148,-0.026225995,0.07198945,-0.05941056,-0.09221673,0.036999773,0.009834497,0.011108284,0.08058756,-0.017858392,0.05215691,-0.020998802,0.047669344,0.10239217,-0.04258616,-0.064442344,-0.022039538,-0.08233493,0.036861364,0.042740036,0.024929812,0.06562401,-0.0078241555,-0.053483546,0.027919717,0.046549093,-0.027686294,0.086478546,0.020797893,-0.049027324,0.018706279,-0.006938493,0.000841567,0.056380033,0.027397383,-2.6729149e-08,0.032807767,-0.052725043,0.029742954,0.019236682,-0.019168444,-0.015491312,-0.015972618,0.035803083,-0.053386524,-0.09392568,-0.0072439415,0.059283197,-0.08102311,0.05759558,0.008543892,-0.0005823474,0.0392614,0.04024945,0.016242974,-0.042406157,-0.088367544,0.02318198,-0.003899766,-0.01593218,0.0251778,-0.05854534,0.027510006,-0.03230143,0.040662277,-0.055668242,0.056541197,-0.00485125,0.018692369,-0.028609116,-0.039374873,0.04878502,0.014930868,0.026108533,-0.007991033,-0.028366506,-0.011602459,-0.049605895,-0.025390966,-0.017805273,-0.088492155,-0.06637616,0.037915234,0.0725666,0.032759093,-0.04677931,0.009238968,-0.01668031,0.0031706907,-0.04983161,-0.11748671,-0.05426449,-0.011051584,0.015206068,0.00094264664,-0.11187576,-0.027408687,-0.003946338,0.10268638,-0.014126848 +2.3.1.230,"The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex. The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue. Together with the PqsB subunit, the proteins catalyse the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring.",384,1.0000001,-0.11116868,-0.034387406,-0.07520705,-0.0309545,0.012195813,0.006721911,-0.01959852,0.043289836,0.05364442,-0.008637114,0.038891304,-0.056011193,-0.088495,0.07561742,-0.08435899,0.050962508,-0.10200197,-0.016863314,0.04261063,0.036758054,0.042201538,0.047677696,-0.11528798,-0.026952129,-0.0007048024,0.09637558,0.08795736,0.075957276,0.007516449,-0.0402,-0.053466525,-0.04393808,0.117566586,-0.040443983,0.1025793,0.08461354,-0.023269773,-0.03778426,0.09322718,-0.020346763,0.07157011,0.012009149,0.037316576,-0.048621565,0.08245766,0.041181143,0.0052005746,0.09689527,0.040266756,-0.042256948,-0.010484647,-0.06611473,-0.025133232,0.09115732,0.022304947,0.0923418,-0.03691439,-0.03498279,-0.08550888,-0.01074159,0.043890916,0.030013612,-0.0148291495,0.005378884,0.0269465,-0.0029764243,0.039021056,0.0016207638,0.082003795,-0.06070013,-0.040259365,-0.017713273,-0.018056331,0.007760284,0.051530812,-0.0050750524,-0.039161175,-0.045626342,0.014973539,-0.015069023,0.044409975,-0.027419649,0.011579552,0.068309024,0.042626977,-0.021261603,0.013987263,-0.0040491563,0.0437784,-0.019863343,0.059213225,-0.003711881,-0.05398563,-0.110630624,-0.057572532,0.055661336,0.0037763922,0.021840325,0.055331163,-0.02163424,0.0403531,-0.0038157606,0.017703077,-0.09968602,-0.025542095,0.03396065,0.037089255,0.113372184,0.03946717,0.0077860323,-0.086535364,-0.008865439,0.03121881,-0.08036969,0.027354585,0.07408023,0.024710136,0.011066159,-0.05211507,-0.004482928,-0.012158763,-0.010617885,-0.005795462,0.029706588,-0.0051182406,0.0052464562,-0.11543204,2.585789e-33,0.026548358,0.024120165,0.037511677,-0.05036316,0.049142238,-0.036099616,-0.04075086,-0.0358689,-0.11953801,0.005120611,-0.031292822,-0.08502453,0.007920748,0.008642959,-0.0075438833,0.009906279,-0.13169308,0.0019188141,0.018639619,0.03442387,0.05478485,0.04521911,-0.05788182,0.018689645,0.106286965,0.063983716,0.06969232,0.031886183,0.007245422,-0.005005589,-0.008493838,-0.022632984,-0.095915034,-0.08265022,0.036553264,0.0036141782,-0.0023018327,-0.048876535,-0.03792209,0.03872767,0.017455654,-0.0010819983,-0.016888276,-0.01043606,0.0345024,-0.030906728,0.0054704114,0.08939894,0.019756615,-0.040487703,0.074552484,-0.07644568,0.039506316,-0.0055509205,-0.045584954,-0.031381078,-0.011014214,0.018167466,0.03864708,-0.0010755338,0.07757344,0.01981767,-0.0816244,0.0185058,-0.019310363,0.023848925,-0.049445204,-0.05794654,0.07651699,0.09791161,-0.05518415,-0.07722658,0.033225168,0.0072533707,-0.004991023,-0.06895529,-0.09625887,0.017360281,0.053317975,0.046656042,-0.010690248,-0.04827543,0.05558835,-0.031221464,-0.05476948,-0.061365366,0.045024607,-0.03478426,-0.012526937,0.0033313099,0.03933417,-0.057822384,-0.03703809,0.06598097,-0.013673702,-3.6257565e-33,0.088375084,-0.13073976,0.020827211,-0.038584944,-0.060234483,0.073102325,-0.037054818,0.001147974,0.069376744,-0.044518918,0.045550287,-0.0013810799,0.010556915,0.0015196525,0.10641143,0.021525163,0.010042005,0.028241968,-0.0007699745,-0.009893262,0.032530207,-0.039547663,0.014449359,0.009306779,0.025763545,0.04746761,0.008752758,0.07763058,0.06009426,0.09203704,-0.05831908,-0.032939997,-0.059494153,-0.03422744,-0.05402286,0.06471003,-0.025549114,0.009325019,0.023759617,-0.008754391,0.03803201,-0.018658748,-0.044312302,0.09026008,-0.01623421,0.025945323,-0.005679857,0.017434329,-0.03779851,-0.100859284,0.047731824,0.02173051,0.0046399077,0.07122644,0.005124259,0.025082856,-0.046795975,0.006961332,-0.0018423636,-0.039236028,-0.05345274,-0.1351619,-0.023736479,-0.058007617,0.06141285,0.0440912,0.0323474,0.018367091,0.018033696,-0.101184994,0.02085642,0.008812145,-0.004213215,0.061488472,-0.039992925,0.012683027,-0.08565066,-0.00040379394,-0.007123031,0.026194856,0.026395617,-0.10406172,-0.037150346,-0.0017674787,-0.003740516,-0.06063281,0.07168208,0.13899629,-0.050842483,0.01653765,-0.0071230717,0.013531383,0.00093148765,0.081898056,0.017359767,-4.2237428e-08,0.021314789,-0.050190095,0.009481003,-0.032623507,-0.021482788,0.05235063,-0.0044946414,0.017227916,0.021956092,0.01340417,0.025790546,0.014274949,-0.049215566,0.028992405,0.06292873,0.02035729,-0.0940084,-0.0058019576,-0.018311834,-0.030157926,-0.04717023,-0.023708576,-0.1303745,-0.03442541,-0.03985521,0.011699298,0.056779213,0.047375128,-0.073501475,0.0105434805,-0.026893422,0.024258468,-0.044482514,0.032141678,-0.07304691,-0.009472151,-0.013355076,-0.06828537,-0.016929217,-0.055011433,0.070367984,-0.016998291,-0.14137347,0.014831982,0.021655291,0.012556402,-0.0065917647,0.03860047,-0.02905919,0.018141095,0.07900294,0.00058993185,-0.0048985654,-0.033531472,-0.13450514,0.015291515,0.0040848134,-0.041133612,-0.043273687,-0.0029457323,0.023834728,-0.034121275,0.16942187,-0.005526584 +2.3.1.231,"The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-[2-hydroxy-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.1.1.290, tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase 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+2.4.1.310,The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin. 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+2.4.1.311,The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin. 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+2.4.1.312,"The human protein is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.",384,1.0,-0.11963091,-0.072675526,-0.15119816,-0.020942662,-0.04516363,-0.014405964,0.07847273,0.06165013,0.05092557,0.037291557,0.0061049885,0.04063167,-0.059622798,0.046389244,-0.07964728,-0.11225199,-0.032247536,0.008802859,0.017108845,0.03204257,0.030353159,0.0046373815,-0.03494278,0.026346477,-0.045857713,-0.027996376,0.023653282,-0.025569895,-0.006851441,-0.0060470826,-0.011552561,-0.025118422,0.039736785,0.03240045,0.023604875,0.084391125,-0.0007607565,0.01047595,-0.033986658,-0.079791196,0.1149844,-0.035768934,0.02190849,0.059114914,0.062673986,-0.045184437,-0.03644056,0.017513823,0.052756425,0.13672383,-0.0058361604,-0.009852372,-0.0055323546,0.055252906,0.008998828,0.025147531,-0.013592923,0.08199927,0.07359789,0.009550277,-0.015103669,-0.10055777,0.034273874,0.01960048,0.065723084,-0.118749134,0.0059355972,-0.03604465,-0.07361252,0.071663566,0.047805227,0.043357354,0.014134533,0.036872167,0.03222308,0.0058433022,-0.06514507,0.027551768,-0.012163464,0.02075192,0.15346184,0.09137074,0.11932645,0.12081519,-0.05567003,0.030495439,0.011590638,0.013585911,-0.016489804,-0.032957345,0.0075746863,-0.007758079,0.0179202,-0.028460784,-0.103328675,-0.042707834,0.041096233,0.014366023,-0.015229838,-0.018492628,-0.034367546,-0.020940308,0.008099436,-0.03729697,-0.07371316,0.10554636,-0.046991806,0.025024408,0.082353614,-0.0043528746,-0.024778558,0.03411285,-0.0154870385,0.02125876,-0.03603161,0.0045526414,0.092635386,-0.12316438,0.017432537,-0.085213296,-0.03340946,-0.036812406,0.0653351,0.039528463,-0.030138025,0.019631697,-0.06462349,2.4431307e-33,0.015403808,0.0029398487,0.052285057,0.038435366,-0.044636294,-0.04467134,-0.00018522376,-0.060169604,0.0021127402,-0.053211436,-0.0063382937,-0.025045605,0.0055096587,0.14412194,-0.049443703,0.07363283,-0.024260502,-0.06632223,0.034655664,-0.09601475,-0.024518812,0.066614784,0.027407708,-0.04857999,0.09434971,0.039078403,-0.07773054,0.017259765,0.079259604,0.0027395769,0.028355828,-0.031623863,-0.017849023,0.014817689,0.08780989,0.025382997,0.001982762,0.00034449337,0.051548596,0.05974465,0.02677239,-0.07414363,-0.041921593,-0.083424576,0.011199277,-0.040406276,0.0293481,0.010656585,-0.10871899,-0.0015155012,0.057240337,-0.04826831,-0.0029260279,-0.035644144,-0.12312851,0.029998876,-0.051257685,-0.09990003,0.00899335,0.038638882,0.033182185,-0.029092496,0.009331708,-0.00442458,-0.05161845,-0.054549377,-0.06908294,-0.043595348,0.013666088,0.015812317,-0.013621938,-0.02898459,0.086450115,0.0048691635,-0.039657,0.00020767999,0.0042188945,0.06795528,-0.041368946,0.04273537,0.0055163894,-0.03917494,-0.017837418,0.022416595,-0.07094947,0.030734807,0.07171898,-0.11457421,-0.049656134,0.020669337,-0.0013335731,-0.025382219,-0.06279457,0.06851846,-0.03632899,-5.198578e-33,0.03552583,-0.07222659,0.019888902,-0.0014786741,-0.027232626,-0.024393735,0.026363447,-0.038703922,0.019010983,-0.007978882,0.029810458,-0.021246858,0.022195002,0.03376811,0.08580504,0.016969925,-0.0928901,0.00024410593,-0.013836098,-0.06604559,0.013487423,-0.045133032,0.010760148,0.060999908,0.042128496,0.027231332,-0.028442413,0.036526967,0.0065592322,0.08560133,-0.104378484,-0.014966103,-0.039969765,-0.035660822,0.01281781,0.01484557,0.00097627676,-0.013639104,-0.004026587,-0.049867716,-0.009426993,0.0399402,0.06495303,0.010068895,0.036481332,0.07183331,0.07361535,0.094099715,-0.08385815,0.020276181,0.04117668,0.0031627186,-0.037752744,0.11965721,-0.018244196,0.08152961,0.049710225,0.061879747,0.038619783,-0.015402679,-0.07045371,-0.062636204,-0.07526489,-0.011087559,0.106744714,0.026989583,-0.035646465,-0.034763087,0.022647023,0.01787035,0.020311723,0.0028084517,-0.01030451,0.016011698,-0.008470006,-0.024190288,-0.13251717,-0.07474076,0.0034245905,-0.034737084,-0.076306686,0.023406196,-0.015061496,-0.057830572,0.060743924,0.023100572,0.03752408,0.09038295,-0.027755162,-0.011725093,-0.016085457,-0.0285743,-0.081117816,0.015437302,-0.046932068,-3.849989e-08,0.0125376275,0.022405222,-0.06990212,-0.106263265,-0.026577786,-0.03961599,0.046329748,0.058940228,-0.016239293,0.030470992,0.001993764,0.01390933,0.051632818,-0.05564093,0.0010830911,0.05913133,-0.054421924,-0.009395372,-0.04205606,-0.031080933,-0.00978535,-0.0009807791,-0.11725443,0.061183266,-0.07013981,-0.033835966,-0.007905473,0.036152747,-0.039273795,-0.020487687,0.053968802,0.01835045,-0.042379152,-0.031466816,-0.008665048,0.04309979,0.013316081,-0.018179948,0.035167865,-0.055361062,-0.028119547,0.06564603,-0.01683075,0.003714394,-0.06073484,-0.007405448,0.045997974,0.019102054,-0.024358578,0.037377905,-0.0012174406,-0.056272104,-0.014647393,-0.048503432,-0.078479186,-0.09174462,-0.028828824,0.025896816,0.059113942,-0.00020640722,-0.02315742,0.042877637,0.099368036,-0.016524455 +2.4.1.313,"The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor [1]. The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.",384,1.0,-0.089347035,-0.10475523,-0.11936225,-0.02221852,0.0037226558,-0.02958373,0.06285768,0.06714243,-0.011119607,0.047545876,0.0028125746,0.043070447,-0.067253605,0.05344267,-0.11019513,-0.06858825,-0.016846696,-0.022592638,0.050652303,0.0632001,0.056776624,-0.017523982,-0.014967003,0.022586482,0.01807903,-0.019794015,0.07052634,-0.059763156,-0.03667267,-0.053332675,-0.014251927,-0.052385453,0.06781967,0.021966629,0.035371743,0.07517441,0.01809574,0.014380947,-0.05603561,-0.055601824,0.08238386,-0.03233687,0.034119096,0.02877765,0.034074865,-0.063831255,-0.056094553,0.029652057,0.07900642,0.10665425,0.04088968,-0.029306877,-0.019549523,0.050635036,0.02301026,0.0638424,-0.012137746,0.020984353,0.07149905,0.028489713,0.016559143,-0.025855038,0.039736386,-0.012461835,0.092521675,-0.10770746,0.022992574,-0.042264633,-0.07101038,0.064030886,0.03926137,0.008025866,-0.010493154,0.0035196808,0.031759236,0.022195045,-0.049313895,0.02184514,0.042191762,0.026680026,0.10071697,0.079690345,0.07232908,0.09245615,-0.04424704,0.03705048,0.020594776,0.04446608,-0.008127654,-0.018114628,-0.025332605,-0.016924584,-0.006000801,-0.032675847,-0.13884854,-0.06464917,0.05049011,0.004945486,-0.009123076,-0.011962113,-0.01863125,-0.023313876,0.019903118,-0.06962056,-0.07322417,0.09001839,-0.044403367,0.0014455484,0.09788384,-0.0034905986,-0.040479258,0.046265732,0.0022227566,0.045178015,-0.038982753,0.040972732,0.019301422,-0.13486974,-0.01841211,-0.06576807,-0.011780689,-0.02990882,0.0892608,0.04387448,0.0051069814,0.043072022,-0.0455903,2.4931642e-33,0.024855925,0.020582002,0.04991891,0.015237543,-0.022526992,-0.004705336,-0.00044448566,-0.05868855,0.010633582,-0.062932596,-0.042053815,-0.02522573,0.042150073,0.13825259,-0.070369616,0.099085055,-0.011914252,-0.07658235,0.043588635,-0.062361293,-0.031767827,0.08215872,-0.020762343,-0.03981703,0.10726087,0.009963197,-0.08717625,0.054758925,0.12986384,0.02277336,0.016679648,-0.029349798,-0.044315033,0.023315322,0.055035703,0.038493168,0.020064916,-0.055263232,0.052892923,0.020220388,0.046153538,-0.054514825,-0.03074211,-0.022868354,-0.016458657,-0.022450028,0.0058956235,-0.030177627,-0.10588792,-0.010124476,0.027598295,-0.064295426,-0.015199498,-0.039402425,-0.09416889,0.038500648,-0.10450434,-0.07452625,0.017723352,0.06665316,0.054030366,-0.007535445,0.016610863,0.0055989115,-0.064151384,-0.040497214,-0.03569609,-0.043939956,0.017471071,-0.0051486488,-0.027210923,-0.046179477,0.100818485,0.0143305315,-0.062050626,-0.02647414,0.04078181,0.058464523,0.00085725985,0.019433755,-0.019203296,-0.01514577,-0.0146051105,-0.0005009615,-0.015681455,0.037747625,0.03788923,-0.11676774,-0.029961774,0.039338067,-0.0005133103,-0.051940206,-0.0973629,0.05817695,-0.03131842,-4.9176512e-33,0.06018582,-0.114487156,0.05898911,-0.0067774546,-0.018269265,0.01155113,0.06065222,-0.029855505,0.04997668,-0.046717748,0.040833123,-0.04398878,0.013081816,-0.017239522,0.10102855,-0.0048486227,-0.095868416,0.023718776,-0.012412485,-0.032389373,0.00080646307,0.012207804,0.002378773,0.04891843,0.002740077,-0.003957429,-0.04354646,0.035755895,0.018344041,0.06303114,-0.05071373,0.013710263,-0.09217005,-0.05312943,-0.0018021589,0.014655256,0.017654315,-0.003087545,-0.014523796,-0.028847331,-0.041310873,0.06570011,0.03855492,0.010489663,0.06031562,0.0763735,0.04015882,0.055046324,-0.024829391,0.015772358,0.05789687,-0.02063912,-0.013161985,0.11036135,-0.026685368,0.067427576,0.063822664,0.05598138,0.04898172,-0.017729541,-0.07051734,-0.05127113,-0.050039154,-0.035445094,0.0962947,0.0030462558,-0.013342419,-0.001687598,0.012980379,-0.023111563,0.010947623,-0.0245496,0.0022555764,0.078779384,-0.004265262,-0.01892033,-0.14114973,-0.05617916,0.02292834,-0.0656101,-0.024637112,0.058115106,-0.0101493,-0.023672378,0.04618841,0.033288494,0.093164556,0.1114674,-0.023285666,-0.004155514,-0.049658384,-0.033957962,-0.10825096,0.005329325,-0.008364013,-4.3231154e-08,0.046566162,0.04548955,-0.04039536,-0.11859038,-0.032235827,-0.012858676,0.014388271,0.03173851,0.014446146,-0.005984398,-0.03729404,0.09344722,0.038160324,-0.023552762,-0.046538457,0.046975035,-0.035883464,0.0031855374,-0.031860296,-0.02456454,-0.043378092,0.004043694,-0.11332368,0.035351608,-0.08015188,-0.017113343,0.031549107,0.08250127,-0.036021262,-0.06048868,0.013467875,0.02581368,-0.0496293,-0.047671642,-0.0019529948,0.061168704,0.021572785,-0.03619358,0.07362362,-0.008475442,-0.017484538,0.022224387,0.012737057,-0.019162754,-0.06038176,-0.0055062785,0.03125328,0.0032217253,-0.03800254,0.04363934,-0.016360208,-0.071226895,-0.069239266,-0.09768994,-0.05225961,-0.09593735,-0.046299558,-0.010000214,0.060338296,-0.019966139,-0.028118096,0.0012132467,0.08749242,-0.0067233327 +2.4.1.314,The glucosyl group forms a 1->6 bond to the glucosyloxy moiety at C-20 of ginsenoside Rd. Isolated from sanchi ginseng (Panax notoginseng).,384,1.0,-0.052162312,-0.018602883,-0.06266394,0.02661375,-0.0038040334,0.034225807,-0.0348868,0.07620165,0.11508553,-0.0027139229,0.015259096,0.032570243,-0.0132685965,0.04498845,-0.031258307,-0.010513842,-0.08301706,0.06892052,-0.078533284,0.025717212,0.06721754,-0.0044968016,0.025597433,0.0024285086,0.08283904,-0.0011360395,0.059009552,-0.042052925,0.0039399113,0.051386513,-0.0146332905,0.020842658,-0.005457347,-0.037932906,0.018686352,-0.02366676,-0.013217698,-0.0712984,0.12477267,-0.0640158,0.019671375,0.080856495,0.041041367,-0.031500652,0.052731972,-0.06085326,-0.09186066,0.024328163,0.010728846,0.08180536,0.03983138,-0.028574917,-0.016554577,-0.027635008,-0.0047762925,0.015378162,-0.049677674,-0.0547878,0.05105412,0.08366361,0.11646935,-0.028536256,-0.07648314,0.059664898,-0.103048064,-0.0075613307,0.051808253,0.07148611,0.038121577,-0.05241638,-0.019396512,-0.04061346,0.049339388,0.015113868,0.028403865,0.014663469,0.027168991,0.020804487,-6.026772e-05,-0.027937932,0.042676847,0.0013723933,0.08392722,0.15663758,-0.01094868,-0.0071551986,0.017571963,0.13301578,-0.00803592,-0.04439676,-0.05514484,-0.00615763,-0.03922445,-0.008280433,0.07293598,-0.012481074,0.0054677124,0.047411926,-0.020545296,-0.014897618,0.00018802015,0.074127614,0.03110054,-0.12250595,0.017016957,0.089275934,-0.02860419,0.008141171,0.055109017,-0.036718275,0.028066067,0.05474854,-0.011342955,-0.061357103,-0.045084577,0.013110771,0.01857833,-0.017252695,-0.005176646,-0.020220723,0.017223649,-0.034157827,-0.024720551,-0.044612516,-0.097797975,0.0009001761,0.061846506,1.812151e-33,-0.006130077,-0.007849963,0.07155972,-0.01914478,-0.012571845,0.014449519,-0.0064647016,-0.072723374,-0.08521362,0.03457048,-0.16286245,-0.05640201,-0.0036577724,-0.0012172239,-0.012407762,0.082917646,-0.030283492,-0.102340855,0.024964793,-0.0784876,-0.0003036582,0.16872871,-0.0694806,0.03765857,0.016090304,0.003258749,-0.015828261,-0.02384462,-0.0009723438,-0.022982951,-0.036030993,0.039488357,-0.048216227,0.014006621,0.08173552,0.02234073,-0.07470175,-0.024114002,0.016525906,0.008882351,0.024918811,0.033947613,-0.04341847,-0.025219804,0.0152522195,-0.045503635,-0.07476873,-0.012940881,-0.012178654,0.11138822,-0.02163438,0.05969997,-0.052946206,0.11245639,-0.08304277,-0.052453533,0.056644045,-0.013199226,-0.005757054,0.01810295,0.015014915,-0.04253787,-0.023657778,0.017529141,0.024234181,0.13917881,-0.06749604,0.026892744,-0.08881104,0.055494487,-0.01359948,-0.0019475588,-0.07376871,-0.02911655,0.013185652,-0.051439997,0.02860238,0.0634701,-2.570471e-05,0.041794147,0.010700547,0.03139179,-0.048031554,0.008209447,-0.10405867,0.029882152,-0.021329831,0.031251505,0.025235806,0.04133962,-0.0066306433,0.012991893,-0.04589876,0.028430864,-0.048808586,-3.792758e-33,0.019087179,-0.06536223,0.06538326,-0.04406855,-0.034463186,0.0477644,0.020681782,-0.105559334,0.0026328305,0.020655965,0.07452911,0.020204816,0.043846894,0.01526448,-0.041952558,0.06400096,0.0010640546,0.09557485,-0.06681082,0.047472667,0.050436605,0.090625495,-0.00033022967,0.012464475,0.033934716,-0.018281117,-0.016524289,-0.037784066,0.026848098,0.0907683,0.07773274,-0.015836326,-0.06280018,-0.052389905,0.029400198,0.056203067,0.009365117,-0.033624426,-0.040906563,-0.05005918,-0.06986364,0.054630723,0.054456294,0.08759207,0.10348864,0.042058762,-0.08553227,-0.03838689,-0.14929368,0.0063389703,-0.061653834,0.028000835,0.011371543,-0.017726878,0.021137048,-0.03955463,0.030327227,-0.0822332,-0.019712066,-0.04564032,-0.019441806,-0.033425845,-0.018807601,-0.044897724,0.05634686,-0.0034944706,-0.04190157,0.10135138,0.013833931,-0.0407978,0.032403633,-0.032400273,0.043239444,0.0014713621,-0.019902049,-0.02183772,-0.026706578,-0.04849195,-0.011204836,-0.019953331,0.07029771,0.020266805,0.041828487,0.040956084,-0.07075099,-0.014689997,0.02982601,0.016849922,0.023951292,0.07338124,-0.07981341,0.0864626,-0.036223814,0.01236912,0.070676096,-2.8432854e-08,0.025811052,-0.020759549,-0.009721342,-0.010867377,-0.071349114,-0.020693246,-0.10900031,0.017657226,-0.025181074,0.03941239,0.032731365,0.024906797,-0.08216791,-0.05312847,-0.117895894,0.015022605,-0.024004355,-0.01768155,0.032607786,0.031583287,-0.0749677,0.0251827,0.009345666,0.008617627,-0.028206462,-0.070103794,0.0058875154,0.011215918,0.045051713,-0.010593564,0.011633724,0.023589607,-0.09261864,0.0009830148,-0.04538745,0.042030983,0.0017576008,0.049622476,-0.005347191,0.011309576,-0.00883591,-0.078732446,-0.024638733,0.0388378,-0.07703469,-0.03203713,0.048642825,-0.016337888,-0.033381652,0.034102842,-0.03516201,-0.038409404,-0.036837045,-0.0231171,-0.096891165,-0.019069217,0.008564531,0.045793384,0.05028424,-0.09684394,-0.09673431,-0.05940104,0.054454397,0.04046362 +2.4.2.55,"The enzyme is involved in the biosynthesis of phenolic cobamides in the Gram-positive bacterium Sporomusa ovata. It can also transfer the phospho-D-ribosyl group to 4-methylphenol and 5,6-dimethylbenzimidazole. The related EC 2.4.2.21, nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase, also transfers the phospho-D-ribosyl group from nicotinate D-ribonucleotide to 5,6-dimethylbenzimidazole, but shows no activity with 4-methylphenol or phenol. ",384,1.0,-0.008995433,-0.0339354,-0.14058207,-0.07955685,0.0040386906,0.05690015,-0.07576311,0.03189351,0.088713646,0.037444364,0.09791722,-0.008542851,-0.10514817,0.03000425,-0.017659895,0.04194089,-0.06435535,0.090139896,-0.030283239,-0.0104013905,0.08023569,0.029902913,-0.0014879418,0.04349608,-0.04717529,0.006945714,0.020972436,-0.0150663685,-0.017002046,0.008511785,0.032105904,0.021058524,0.017998494,-0.089644544,0.08282737,0.074089825,0.03459819,-0.08433314,0.08094994,0.07755939,0.064832,0.0026829783,-0.0066035856,0.02150898,-0.08850434,-0.03223228,0.014735935,0.07589903,0.037537467,-0.078066185,-0.10319805,0.0005185747,-0.005125349,-0.04257741,-0.04420784,0.10377694,-0.02754269,-0.03637178,0.006005396,0.029803988,-0.010204535,-0.011599658,0.019956108,0.04361686,-0.07195978,-0.039457105,0.056244835,-0.088762306,0.017715666,-0.050785907,-0.08316848,-0.085994065,0.04929931,0.038002845,-0.0275239,0.07199423,0.0037895693,0.013564329,0.03239659,-0.084321044,0.02366178,-0.042933356,-0.026496703,0.009609059,0.008041451,0.015118097,0.015283105,0.047665738,0.1270993,0.04804306,0.018297935,0.019207215,0.12409656,-0.045331538,-0.12623876,0.06372383,0.029658707,0.08032246,-0.027837574,-0.031987466,0.048617374,0.035934087,-0.018942924,-0.060271613,-0.010072131,-0.02198168,0.004495484,0.105919436,-0.01510062,0.030892082,-0.0051018787,0.023932261,0.00984139,-0.025239078,-0.028728945,0.039287187,0.01574241,-0.054563314,-0.0750288,-0.013036192,0.0036845137,-0.1004854,0.08409597,-0.02221426,-0.024374481,0.059383355,-0.11668595,7.092461e-33,0.08781367,0.06387259,0.10664972,0.015650209,-0.038163744,0.0061919903,-0.118585005,0.023684388,-0.02865504,-0.118208185,-0.113762654,-0.082058005,0.005881259,0.01012545,-0.010177357,0.03907909,-0.08302817,0.0053231767,0.087381266,0.05572127,0.038965598,0.016991097,-0.02173544,0.069751106,0.05459974,0.045605276,-0.07055563,-0.06956318,0.0063756523,-0.0007015779,-0.017680796,-0.043663453,-0.10417103,-0.039532214,0.015715614,-0.0070492313,-0.03063243,-0.05278119,-0.01174421,0.046347674,-0.013474443,-0.013411954,0.035161115,0.02554667,0.018688226,-0.00594074,-0.05679886,0.012057934,0.062606834,0.10220778,-0.029159563,-0.054352336,0.089473456,0.03731211,-0.064029746,0.008408423,-0.013810712,-0.0027372674,0.06341149,0.011147424,-0.029605014,0.09715326,0.038705237,-0.002431797,0.02332213,-0.054234494,-0.034592643,-0.10898934,-0.049312744,-0.0092969,-0.0013320533,-0.047005422,0.033298317,0.031179069,0.050950844,-0.09265675,-0.04867833,-0.08580097,-0.0301128,0.057045437,0.001477665,-0.05357493,0.04929069,-0.046155795,0.009770433,0.02803378,-0.019291641,0.009374846,-0.020435479,-0.007926608,0.023967033,-0.08240494,-0.017777547,0.020114206,0.022641938,-6.540459e-33,0.032014936,-0.04098384,0.066769965,-0.047631215,-0.035115574,0.019311171,0.010720494,0.014269367,0.0006527607,-0.008472391,0.05166562,0.010983983,0.022048775,-0.037460703,-0.024995452,0.015525839,0.045623317,0.03567506,-0.0009822843,-0.0017797116,0.024573535,0.013790984,0.010293719,0.03975184,0.041755836,0.008489313,0.046383057,-0.0048708576,-0.043793898,0.019556696,0.030625233,0.08932442,-0.068409435,0.007457644,-0.0098444475,-0.027467977,-0.05406947,0.0028487185,-0.0041002934,0.011469542,-0.0530825,0.051677894,0.017290184,0.008520749,0.014143623,0.026866814,-0.054626666,-0.016036063,-0.012699371,-0.00806052,-0.0022537492,0.08395814,-0.038725365,0.06898866,0.06623404,-0.010137526,0.014164818,0.0524423,-0.05599042,-0.032833602,-0.0580508,-0.055157933,0.0019687873,-0.03466067,0.116036855,0.087011985,-0.0033237222,0.09298296,0.017617038,-0.045608453,0.0063396073,0.022798385,-0.026532305,0.05791137,-0.037937175,-0.028923387,-0.1006926,-0.059549786,0.015928831,-0.0003885315,0.011181619,-0.07640255,0.07816068,-0.01705982,-0.022589669,-0.06796209,0.055679068,0.021720974,-0.01577034,0.04701273,0.011213153,-0.011035576,0.030434817,0.03652011,0.05957547,-4.652469e-08,0.041033916,-0.027432825,0.016280275,-0.0863629,0.049141515,0.0027364977,-0.06528596,0.009409545,0.10585514,-0.02208759,-0.03935807,0.008619336,0.039023977,0.11031025,0.034350622,0.07261188,-0.085797526,-0.0047915005,-0.015698714,-0.006017867,-0.023617513,-0.008706556,-0.105849765,0.09552817,0.023409298,-0.036574353,0.061679043,0.049697574,0.05188215,-0.044206742,-0.024259597,-0.036644254,-0.020229276,0.03064742,-0.046850633,-0.012007872,-0.029668324,-0.036416557,-0.056590606,0.07115129,-0.015231868,-0.083763696,-0.084450506,0.048788354,0.035590064,0.03387521,-0.010345772,0.06480053,0.003924028,-0.011880239,0.030818336,0.06231705,-0.015155943,-0.092599094,-0.147426,-0.045958847,0.01080478,-0.024888964,0.01623245,-0.04319994,0.010047289,-0.0037253557,0.092130005,0.011864227 +2.4.2.56,"The enzyme from the plant Euonymus alatus also catalyses the 3-O-D-xylosylation of other flavonols (e.g. quercetin, isorhamnetin, rhamnetin, myricetin, fisetin) with lower activity. ",384,0.99999994,-0.07072019,-0.02131036,-0.11634308,0.047047865,0.058369353,0.06140381,0.03104287,-0.011163958,0.0608319,0.037350576,0.0835567,-0.014608784,-0.08763673,-0.043110795,-0.03401098,0.05839215,-0.0077117453,0.09818894,-0.087463275,-0.0012720198,0.084066905,-0.0065581845,0.11057425,0.030801794,0.063832134,-0.02132942,0.0057761255,-0.020267988,0.015587495,-0.1258198,0.026687354,-0.039334506,0.089667074,-0.012361671,0.016143177,0.01761657,0.0035849346,-0.12223832,0.00726634,0.012708846,0.06738678,-0.038678944,0.017010754,-0.055524763,-0.0857424,-0.049449228,-0.07660989,0.045601852,0.04093781,0.017247543,-0.006409717,-0.061098866,-0.06869311,-0.02895943,-0.001651933,0.012915777,-0.013920194,0.046185497,-0.07545317,0.02872244,0.11424243,0.02879045,0.02389287,0.070136935,-0.05521184,-0.042848878,-0.050530054,0.00959186,0.018050669,0.012801985,0.00094583654,-0.08817925,-0.028159263,0.023426922,0.044539258,0.07549199,0.010761699,-0.059476588,-0.018723138,-0.03219756,0.035280034,0.01843116,0.042767353,0.07473447,-0.008234622,-0.028263435,-0.068087064,0.037304565,0.046696447,0.060522337,0.06517767,0.024756197,-0.05288002,0.01775364,0.00828272,0.0732702,0.13243073,0.00059167994,-0.05571248,-0.021497233,-0.02580016,-0.013458644,-0.016669966,-0.073156215,-0.04160578,0.025966369,-0.009978062,-0.036017783,0.009573839,-0.06813147,-0.05179307,-0.10850389,-0.0071711545,-0.027243821,-0.037989717,0.07940014,0.042987,-0.0422681,-0.039500628,-0.03277078,-0.03062563,-0.012826364,0.03528447,0.07110132,-0.004987784,0.015038052,-0.046122633,2.6656728e-33,0.06143114,0.06043533,-0.12805504,-0.037621327,0.0027287283,-0.009444405,0.016235901,0.011844438,-0.05126017,-0.029953294,-0.120106116,-0.008943249,0.022108268,0.017669404,0.032124612,-0.015486974,0.010106261,-0.0076228003,0.04279244,0.002176523,0.11772725,-0.022849374,-0.091988675,0.03760999,-0.030378398,0.04153041,-0.0057892352,0.014863426,0.0009185794,-0.018617267,0.012549266,-0.06632506,-0.03226672,0.049381502,-0.011835656,0.0885305,-0.065118015,-0.07870694,0.0038344115,0.052143607,-0.043234665,-0.002008452,0.036727086,-0.065584555,-0.0019925234,-0.0059982543,-0.08040262,0.009910158,0.07840584,0.030307239,0.08232765,0.0031065475,0.12405698,0.093450576,-0.032203626,0.048787594,-0.057031304,-0.0038303207,0.038204923,0.012325195,-0.04167023,-0.03980705,0.002778526,0.020286186,-0.0046072346,0.065483145,-0.0487698,-0.04229045,0.002486927,0.05190372,-0.02071566,-0.10356513,0.035617806,0.008288239,0.12837946,0.00081564236,-0.03893784,0.00043837132,-0.06551144,0.037135847,0.027792076,-0.0049047195,0.0113722235,0.041584868,-0.014921779,0.039205085,-0.055969644,0.07666275,0.0918775,0.056538835,0.00918839,-0.07143447,-0.050630003,0.0055377525,-0.01981475,-2.8432668e-33,0.057709727,-0.038394306,0.036959898,0.0069908537,-0.050494544,0.050737265,-0.006086158,-0.012107815,-0.0025415926,0.004067014,0.07143685,-0.03235673,0.009557979,-0.022507172,-0.01191115,0.013097533,0.028609676,0.09984463,0.040081657,-0.0025615909,-0.09851627,0.0060569933,-0.035746098,-0.016408298,0.07504045,-0.04782672,0.033281196,-0.044287063,-0.007532164,0.0594908,-0.023698956,0.021150056,-0.045164034,0.025326775,-0.004785888,0.09181781,-0.08068644,0.002453859,-0.0617576,0.057243362,0.026059892,-0.024489535,0.081927344,0.03154166,0.06333637,0.062377412,-0.10446781,0.03150458,-0.06585952,0.06333966,0.051324245,0.079900056,0.026708566,0.07873711,0.062153023,0.02747305,0.06420781,-0.022661943,-0.020945018,-0.019842384,-0.044064093,-0.07085786,0.02203664,-0.029769141,0.07706163,0.075740576,-0.06007683,0.09051268,-0.009746545,-0.02707351,0.10519933,-0.06617338,0.005715349,0.07826828,-0.027111439,0.004206613,-0.050217632,-0.01609837,-0.021138966,-0.0285358,0.022145446,-0.020184474,0.04921549,-0.10481757,-0.061526906,0.011261369,-5.359105e-05,0.068555914,-0.010929383,0.045593332,-0.02792651,-0.04103827,-0.034497168,0.0026012708,0.11971419,-3.5574264e-08,-0.046176232,0.012218798,0.073185965,-0.009073563,-0.009941384,-0.015778175,0.01329897,0.024234697,-0.005333331,-0.0073410915,-0.04828501,0.066194974,0.03233979,0.02336089,0.010855338,-0.025507208,0.05147219,0.05037814,-0.010918629,-0.039124545,-0.089727096,0.029396415,-0.057136334,-0.021927273,-0.009785378,-0.037746653,0.049148936,0.04609984,0.10471594,-0.049843267,0.017112121,0.012442354,0.004796209,-0.016091915,-0.12300092,0.024649912,-0.053659014,-0.07282907,-0.02015671,-0.0090749655,-0.09035356,-0.04006031,0.025354775,-0.0059303613,-0.024904883,-0.003175472,0.05093538,-0.031061018,-0.012090827,-0.0413224,0.008420161,-0.047679998,-0.0076250536,-0.097976804,-0.061950564,-0.019005891,0.047117595,0.00059207814,-0.024384527,-0.07204492,-0.08201346,-0.0031013137,0.15575272,-0.035031077 +2.5.1.112,"Involved in the biosynthesis of cytokinins in plants. The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP [1]. Other isoforms, such as IPT1 from Arabidopsis thaliana [1,2] and the enzyme from the common hop, Humulus lupulus [3], also have a lower activity with AMP (cf. EC 2.5.1.27, adenylate dimethylallyltransferase).",384,1.0,-0.10540326,-0.008295459,0.01171745,-0.031662032,0.008857473,0.023099892,-0.030401606,0.0484443,0.09167097,0.013534335,0.1210113,-0.03765634,-0.0804054,-0.0532485,-0.010373155,0.04884575,-0.03652705,0.12979114,0.0002681454,-0.08077191,0.042001728,0.0711032,0.024956392,-0.027790638,0.050911486,0.0150395455,-0.052084133,0.04141391,0.01637941,-0.077184014,-0.0511013,-0.006723371,0.0712171,-0.011488676,-0.021382375,0.0845623,-0.0032093737,-0.04129683,0.11300247,-0.027584206,0.1719002,0.0035891798,-0.015896032,-0.024708914,-0.06463115,-0.009126995,0.008001327,-0.029954055,-0.0338527,-0.014937255,-0.0039009668,-0.011624146,0.04804856,-0.0048377165,-0.0066043367,-0.015270536,-0.029944703,0.052458256,0.059122182,0.021510456,-0.00465916,0.0024167686,-0.019751806,-0.015121423,0.044087954,-0.045660377,-0.017612927,0.015948236,0.06151649,-0.028565818,-0.04662893,-0.03331551,-0.09725055,0.04013406,-0.0784793,0.14628333,-0.039824933,0.00090614986,-0.05894108,-0.020120842,0.076429844,0.061798774,0.025992187,0.024055118,0.021745082,-0.039944217,-0.0034099128,0.047415107,-0.028707393,0.017182734,-0.0033886288,0.033985537,0.01913052,-0.013645341,0.008331685,0.017341558,0.03999884,-0.009169617,-0.0251494,0.009034408,0.044826746,0.10568219,-0.12037461,-0.06941713,0.021318369,-0.0058167637,0.006233311,-0.02326718,0.0014829753,0.0434562,-0.018730285,-0.05236915,-0.060476486,-0.026960103,-0.0017652733,0.049318668,-0.0767056,-0.014306445,-0.052317712,-0.027688729,-0.06946606,-0.124864995,-0.0023842047,0.028423939,-0.028952379,-0.02183124,-0.14374101,4.060154e-33,0.08070947,0.004718575,0.035661865,-0.003078129,0.003819703,-0.012920312,-0.030636743,0.0009935473,-0.013671249,-0.062181212,-0.09722646,-0.060953528,0.033777762,-0.010310683,-0.09689525,-0.045626283,-0.053784028,-0.01554441,0.13797344,-0.057981774,0.003821204,0.021527488,-0.08664374,-0.013897214,-0.014836075,-0.028333634,0.008226233,-0.051631317,0.020775838,-0.010827606,-0.027751353,-0.048478767,-0.052451998,0.02482366,0.029104747,-0.019678812,0.012902532,-0.06884618,0.02297613,0.032253377,-0.09418631,0.0044647288,0.040106494,-0.03409907,0.093092434,0.06944866,-0.018307699,0.0065787425,0.04999399,0.10123292,0.016830344,0.019819746,0.10531426,-0.07205068,-0.016594607,0.010258681,-0.02041071,-0.013102102,-0.06868138,0.095180325,-0.0074972124,0.05753539,-0.027240597,0.00047049037,-0.023582103,0.1352515,-0.13283823,-0.12926489,0.006075929,0.10657416,0.023748154,-0.06431198,0.059707366,0.0038513876,0.052101627,0.058543637,-0.009087448,0.049410295,-0.048272345,0.019875001,-0.049041845,0.02865776,-0.0061045233,0.019609578,-0.02906817,-0.0687172,-0.0044227242,0.01507489,0.025471821,0.03211774,0.092671484,-0.016707651,-0.13230556,0.074518144,-0.031341452,-3.8328477e-33,0.051577903,0.061846633,0.013656113,-0.09219603,-0.10214853,0.063198,0.019471478,0.033552617,0.020941287,0.05405714,0.039830673,-0.0023315507,-0.0025717919,-0.0070835953,0.0004362366,-0.021268986,-0.025561366,0.048607502,-0.0010692078,0.08386,-0.043655872,0.076793686,0.021700352,0.08910397,0.042500902,-0.003537795,0.06386216,0.07589299,0.00025295955,-0.017166724,-0.008082894,0.039474145,-0.048351236,-0.021947462,-0.00212217,0.004869567,-0.021620415,0.045927897,-0.04952537,0.013223924,-0.05952742,0.0019911209,0.030942917,0.042676467,0.039455034,-0.0086547425,0.024960337,0.032339018,-0.06855548,0.0022512258,0.042221017,0.043526854,0.011208259,0.0738352,0.05647794,0.05006851,0.03642049,0.07187581,-0.023041906,-0.039776236,0.011382322,-0.09060608,0.0449478,-0.034561176,0.04933006,0.0018099142,0.030362867,0.021659214,-0.027376303,0.045857318,0.057473123,0.0017619766,0.047595274,-0.029478421,0.009413948,0.03951867,0.006127272,-0.066925995,-0.055784274,-0.012960848,-0.029294036,0.065996975,-0.039729375,-0.10583653,-0.018099105,0.019964445,0.054223906,0.09439669,0.03361835,0.074690424,0.021161558,-0.00067982334,-0.027583018,0.074525006,-0.015478074,-4.1584652e-08,0.0010501817,0.0024431949,0.05962721,-0.008495325,-0.040532984,0.03403586,0.008799859,0.0484081,0.017942794,0.027996954,-0.021156259,0.043233328,0.0010778926,-0.014287588,0.08754406,-0.016702112,-0.015402534,0.05015718,-0.0072592576,-0.0021394072,-0.11240256,0.009405206,-0.10877531,0.04542402,-0.0017571613,-0.0833674,0.07735095,-0.0052952585,0.03686655,-0.021584127,0.04921247,0.008705883,0.015059531,-0.100988716,-0.076814935,0.009510725,-0.03910481,-0.061978407,-0.026825981,-0.0041803652,-0.11394894,-0.0822031,-0.017462933,0.026079511,0.0044335066,0.0015560706,0.016814658,0.030995682,0.019385196,-0.034482174,-0.009437053,-0.030682398,-0.019709334,-0.14096873,-0.034347445,-0.025868803,-0.054925937,0.0012804723,-0.01768215,0.016164854,-0.026036752,-0.0022472532,0.107086815,-0.01692725 +2.5.1.113,"A pyridoxal-phosphate protein. The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor. The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O3-acetyl-L-serine (cf. EC 2.5.1.65, O-phosphoserine sulfhydrylase).",384,1.0,-0.0325007,-0.069578335,-0.072498776,-0.039895903,0.060555767,0.04267494,-0.019505244,0.074463375,0.061405856,-0.005413734,-0.016840711,0.058500607,-0.0072267456,0.05807004,-0.024449207,0.093831256,-0.02909142,0.026191615,0.006545392,-0.069174245,0.0930568,0.06664295,0.025135703,-0.03244442,0.026467044,0.043240063,0.031623192,0.042242434,-0.069043875,-0.050397757,-0.0605457,-0.060054272,0.0031479953,-0.047052454,0.07643368,0.098858155,-0.06920906,-0.03494801,0.04030447,-0.0073574283,0.043700956,-0.040933713,-0.046497475,0.030304173,-0.05303874,0.013576125,0.002540315,0.027481353,0.026080647,-0.042109683,-0.09535529,0.0020058227,-0.03759434,0.021244772,-0.014624154,0.025266554,-0.012546436,0.032504342,0.0050489483,-0.05451651,0.018132402,0.02068829,0.020089151,0.013484981,0.07313385,-0.026727354,-0.016271891,-0.0857569,-0.019686708,-0.033807416,-0.08581678,-0.040131263,-0.00040403,0.08113662,0.002837737,0.02853005,-0.050050776,-0.014059391,-0.0036078796,0.04575141,0.02014063,-0.02368395,-0.04940646,0.07095628,0.03646493,-0.040338654,0.05320422,0.012982234,0.028681533,0.015038027,0.028926106,-0.03837345,-0.013915589,0.007189509,-0.066034116,-0.031368643,0.07664289,0.027815308,-0.056604158,-0.033758678,0.027018394,0.03388488,-0.005291909,-0.08699533,-0.05667624,0.013999505,-0.03294456,0.05432883,0.0030764174,-0.015643517,-0.029431745,0.0030770567,0.025333505,-0.028695531,-0.01911079,0.086873375,0.081144325,-0.030831084,-0.10852784,0.041709747,0.030881405,-0.055506546,0.0014029522,0.08914853,-0.058997743,0.03715952,-0.14595136,2.0703473e-33,0.10275413,0.03294268,0.08098066,-0.018691935,0.026844924,-0.039071366,-0.0661209,-0.020462794,-0.032340884,-0.003918624,-0.043039568,-0.06504701,0.04594976,0.0074144043,-0.09278068,0.008384553,-0.07744439,0.014097901,0.1234545,0.067548625,0.03835943,0.023446547,0.007082885,0.10312416,0.023547715,0.102493726,0.02688614,0.0068377405,-0.0097428635,0.01703881,0.015317518,-0.11171487,-0.073224775,-0.07489469,0.061572637,-0.078794174,-0.077174015,-0.06797815,0.042281773,0.011122816,-0.03957017,-0.022200644,0.034682967,-0.017666176,0.029754505,-0.08193496,-0.029901514,0.058464408,-0.03047043,0.027675634,0.07319928,-0.09950992,0.051121388,0.019943845,-0.04486005,-0.046300154,-0.04721918,0.037227906,0.024749497,0.04488384,0.08045261,0.023159953,-0.05876478,0.03805288,-0.05892958,-0.025638351,-0.030624758,-0.04347088,0.01387844,0.095533125,0.0054616886,-0.02313319,0.035518356,0.0059255892,0.047873683,-0.011871633,-0.06843608,-0.010315284,0.05504576,0.0073911077,-0.023757959,-0.06439235,-0.055205043,-0.023761488,-0.06976829,-0.07372263,-0.021169003,-0.046206493,-0.041399036,-0.01309975,0.005136079,-0.07280671,-0.052685227,0.08182335,-0.010159749,-3.4567263e-33,0.11045889,-0.11594866,0.13065283,-0.09479,-0.030290544,0.013127744,0.06712952,-0.026834384,0.06607722,0.033021525,0.04270025,-0.017186442,0.031702127,-0.015940197,0.012845971,-0.0029159684,0.006695804,0.0107561145,0.00415157,0.039152905,0.0027897803,0.07826927,0.038754303,0.022834301,0.031546965,0.051207244,-0.052124027,0.039960973,-0.0061764168,0.050207794,-7.034996e-05,0.06793225,0.0068394034,-0.110519305,-0.103719905,0.04276543,-0.071782164,-0.03829518,0.043651454,0.016413476,0.007401925,0.045644473,0.037797425,0.02486415,0.0032312095,0.007517376,-0.05483793,-0.022854222,0.027821321,-0.0605365,0.0338581,0.027311878,0.014032078,-0.005164748,0.045093775,0.05168643,-0.052226722,-0.014903013,0.02585023,-0.012906179,-0.052962866,-0.078278914,-0.007485737,0.040375438,0.029020123,0.09417993,0.014149258,0.026939802,0.0876041,0.0004010203,0.05782089,-0.03511047,0.05508599,0.094454795,0.0011156218,-0.0146860685,-0.07753315,0.112803705,0.026643254,0.02775715,-0.0774789,-0.02206799,-0.024178809,-0.093345605,0.0032138985,-0.084642984,0.009566972,0.103206925,-0.017249992,0.027194092,-0.04196781,0.041553624,-0.0517384,0.055454254,0.05200852,-4.084139e-08,0.027288398,-0.061005898,0.06932605,-0.009739501,0.009820069,-0.011753399,0.04851339,0.05448391,0.07751482,0.023198776,0.041888006,0.04789672,0.0327506,-0.046801202,0.1018725,0.06179397,-0.012425131,-0.010828708,0.0023662343,-0.061366558,-0.018176086,-0.016566837,-0.08695505,0.055439394,0.053643364,-0.057189174,0.019125061,0.00013458372,-0.068621844,-0.01637483,0.008976267,-0.009976263,-0.004701796,-0.074904844,-0.100080475,0.06486759,-0.07125447,-0.05801727,0.00941874,0.0060398257,-0.06348789,0.014061684,-0.06938726,0.008886697,0.017552607,0.04592046,-0.018171318,0.0202754,-0.049250863,-0.050313223,0.048299305,-0.03278831,-0.07865953,-0.058318615,-0.09437963,0.08096818,0.024305781,-0.0094510615,-0.001677565,-0.09323938,0.020156613,0.0013696394,0.124731116,-0.07724902 +2.5.1.114,"The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases. This modification is essential for translational reading-frame maintenance. The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNAPhe.",384,0.99999994,-0.06533232,-0.018881198,-0.12290067,-0.06073018,-0.00093600195,-0.02714597,0.013820365,0.021970958,-0.018313559,0.029290939,0.06822765,-0.06384269,-0.10677006,0.044618785,-0.09482217,0.02380481,-0.14930725,0.011704516,0.019715792,-0.05073337,0.06459244,0.07070484,0.0006436868,0.024088934,0.026219696,0.017904896,0.015218559,-0.029918244,0.022938497,-0.053749118,-0.088213585,-0.04121145,0.06544963,0.03536927,0.013273875,0.094390795,-0.08375521,-0.08115947,0.08140677,0.022714429,0.034889556,0.044780526,-0.029739957,0.042920638,-0.024841223,0.05012528,0.028488941,0.023900075,-0.035346378,0.052924473,-0.038363606,-0.12158754,-0.033380736,0.033006255,0.023081977,0.06103102,-0.031715874,0.020318268,0.049075704,0.01316608,0.05597468,0.018912934,0.052410156,-0.04158024,0.07683199,-0.066168934,0.05294866,-0.02359894,-0.0019382809,-0.05085136,0.036968883,-0.02354394,-0.044739705,0.049092878,-0.107197985,0.05962931,0.0073176236,-0.04928001,-0.019548537,0.032767672,0.013404536,-0.00020921885,0.10925838,0.016269498,0.06973851,0.002018645,-0.06110655,0.016661802,0.021904392,0.012291243,0.10840411,-0.009876032,-0.022029202,-0.02821943,-0.0303644,0.061550476,0.07325038,0.053253133,0.019919965,-0.03928999,0.028779142,0.028794207,0.01193295,-0.03237371,-0.035142653,-0.006691427,0.08682022,0.01812873,-0.05375855,0.0077551776,-0.07259922,0.024925573,0.036828272,0.017078413,-0.012113325,0.05714584,0.02504859,0.03601314,-0.0063901474,0.0012715973,-0.008660143,0.04027797,0.09020563,0.02898999,-0.03338555,0.028667234,-0.068483874,3.374723e-33,0.050126147,0.037148606,-0.07840201,0.01713471,0.015120176,0.0013456305,-0.06836835,-0.029563548,-0.08721947,-0.081429034,-0.116706975,-0.017956316,0.05618159,-0.030890059,-0.04968356,-0.029471504,-0.017900396,0.038190037,0.012438628,0.044544205,0.03718967,0.023090243,-0.048603985,-0.025294503,-0.03351534,0.021856649,-0.04543577,0.025241502,0.007923211,-0.0055916863,-0.036968775,-0.105903745,-0.07630644,0.01118568,0.08154183,-0.026353568,-0.045426227,-0.055699226,-0.07940068,0.005320559,0.03913967,-0.022715926,0.012989835,0.00016169998,0.04793348,0.008761855,-0.034427185,0.058511283,-0.026140606,-0.031193713,-0.022513894,0.012992471,0.053737197,-0.023060966,-0.064409554,0.03739972,0.036255103,-0.09438284,0.07314083,0.021944348,0.004784744,0.01884214,0.0037243837,0.044702876,0.0040849987,0.031171832,-0.12675844,-0.053768,0.000839002,0.050845854,-0.045900363,-0.109055385,0.071630254,0.036797855,-0.011652917,-0.035438914,-0.022690902,-0.059845973,-0.11175101,-0.01912657,0.0106795365,-0.03701043,0.05457126,-0.04027364,0.0339348,-0.03290944,0.0019067508,-0.062288083,0.021167649,0.045883283,0.055583593,-0.03142338,-0.083470024,-0.040482156,0.043485135,-3.4217594e-33,0.045168113,-0.0676254,0.0065492247,-0.063154526,-0.121010974,0.0733483,0.0012050939,-0.09345429,0.003891782,-0.042870697,0.09929745,-0.020408973,-0.0664731,-0.03840979,0.044789165,0.034578152,0.055338275,0.037907705,0.039683737,-0.053235527,0.0039252006,0.027404096,-0.03479167,-0.00857473,0.03912287,-0.0003707774,-0.02047235,0.042680223,0.02936929,0.050698824,-0.115376316,-0.04796164,-0.00096815877,0.03351339,-0.023501582,0.0145583525,-0.011554064,0.00020201622,0.069913395,0.018132022,0.060789187,0.023080032,-0.0054410626,0.06952165,-0.0011682567,0.11280732,-0.03802003,0.022760885,-0.110927515,-0.049084403,0.07822046,0.011198789,0.042434055,-0.005892926,0.085795075,0.05829169,-0.010912146,-0.01010727,0.009090317,0.0064390944,0.026332991,-0.07625798,-0.024416089,-0.013851907,0.039294347,0.03130184,-0.06064963,0.14604755,0.0090046795,-0.03693248,0.010342395,0.022705285,0.034578834,0.06233532,-0.0423337,-0.012726519,-0.024740394,-0.06126887,0.02437464,-0.115823455,-0.01053001,0.018574197,0.02394741,-0.081453934,0.036182977,-0.075370826,0.039253015,0.101190545,-0.005535222,0.059341747,-0.011271691,-0.030744655,-0.01145633,0.08279714,0.10346584,-3.8983547e-08,-0.048572246,0.006549982,0.00942945,-0.039972574,0.03072312,0.0048215766,0.013868052,0.047975898,0.05651537,-0.030587004,-0.06431387,0.007260553,0.018538868,0.05184814,0.061028495,0.10884275,-0.0677342,0.022881055,0.0023298806,0.033754554,-0.0050674435,0.033218727,-0.08440991,0.052282613,-0.06224664,0.034551516,0.05060735,0.095542714,-0.046406575,-0.07274413,-0.013799126,0.016287714,0.02095424,-0.028284496,-0.0595733,0.054046653,-0.041869905,-0.06586101,-0.075833455,0.017222414,-0.035776667,-0.02429431,-0.047830578,0.0136760585,-0.013367991,-0.0019555502,0.008524879,0.07118245,0.01917514,-0.020759147,0.0807568,0.010380556,0.060338166,-0.018222624,-0.08165086,-0.012824559,0.027038949,-0.055845544,-0.081263885,0.00425567,-0.019008698,0.014458567,0.16790465,-0.07254592 +2.6.1.103,"A pyridoxal-5'-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.",384,1.0,-0.06534999,-0.029805971,-0.084469095,-0.08343264,0.018564936,0.015553482,0.033655453,-0.007971107,0.100873895,0.00546925,0.015625475,0.024276806,0.016568603,0.069672436,-0.09710809,-0.005081983,-0.09877231,0.03249969,0.020669289,-0.031675916,0.024782518,0.039878253,0.011165131,0.0053242357,0.036206078,0.0665006,0.047780305,0.003050439,-0.016158821,-0.056994054,0.028403126,-0.014966196,0.008556951,-0.07576469,0.024551604,0.109357595,-0.095907524,-0.049247056,0.10689977,0.019225532,0.019673403,-0.022935638,-0.027390223,0.040290043,-0.07590947,0.036202963,0.0063967984,0.051337745,0.09156719,-0.013379478,-0.07619667,-0.02597822,-0.09129497,-0.008518765,0.049374238,0.04288175,-0.021868348,-0.008224228,-0.014206314,-0.064470954,0.015144639,-0.01974808,0.053237084,0.018547716,-0.07545652,-0.047357716,-0.019151129,-0.0843608,-0.005377451,0.0048279087,-0.082459725,-0.026704328,0.077815406,-0.005973577,0.004566653,0.01874581,-0.05214847,0.009253476,-0.036535278,-0.03340025,0.04417553,-0.036850654,0.051401425,0.121084,0.061516535,-0.043889895,0.058987226,0.0068675214,0.06909214,0.018777618,0.039462212,0.0023811802,0.0015408178,-0.04501447,-0.042557497,0.007990934,-0.089272164,-0.048570674,-0.029646033,-0.03058927,-0.024785906,0.018417763,0.042987447,-0.065299004,-0.05281538,0.0070820567,-0.038513318,0.08520423,0.015714608,-0.02403239,-0.034737784,0.054179188,-0.011625331,-0.047380768,-0.020728609,0.04516726,0.080433354,-0.041542906,-0.06528496,-0.023676965,0.014174482,-0.01725174,0.010948767,0.031237923,-0.052148443,0.05540938,-0.13599968,3.5497105e-33,0.04560208,0.10421878,0.029558305,-0.015730156,0.0194997,-0.045868196,-0.07549534,-0.035430502,-0.041721083,-0.014272105,-0.040467028,-0.06090364,-0.010841068,0.040824678,0.01512864,0.0203165,-0.044025518,0.054281022,0.033075105,-0.010333982,0.036013216,0.06833691,-0.021217918,0.03445476,0.078367785,0.10805263,-0.043641005,0.0010918523,0.07362138,-0.015543001,0.012285201,-0.06774985,-0.13748422,-0.031998977,0.06875659,-0.03243947,-0.024361433,-0.05048281,0.053673755,0.06556192,-0.008594617,-0.027926452,-0.013550549,0.013494966,0.050903805,0.014344221,-0.008957509,0.083154045,0.04228871,0.051695216,0.045004442,-0.09871518,0.09689879,-0.012807412,-0.11506818,0.029438104,-0.013135521,0.007914704,0.028506001,0.060552616,0.024847675,0.032926675,-0.020113913,-0.030595975,0.036596123,-0.01406896,0.033843543,-0.05491917,0.011074845,0.037676405,-0.019583458,-0.026514973,0.079228684,0.050600976,0.004307734,-0.03442244,-0.050812114,-0.07262714,0.045461606,0.05431488,-0.024566503,0.033735916,-0.011178141,-0.07177757,-0.026513236,0.024545174,-0.012867888,-0.081260495,-0.0017011397,0.048932094,0.022359373,-0.059271824,-0.033203267,0.019569872,-0.09881345,-4.1154935e-33,0.06256461,-0.16032614,0.061221812,-0.0030185145,-0.08944734,0.018806426,0.014230651,0.0024259998,0.023877976,0.008531491,0.07542627,-0.011990425,-0.015248206,-0.041095268,-0.0013452057,0.013570556,0.010415918,0.08359392,-0.002136732,0.008427589,0.037233815,0.07151258,0.004797714,-1.3398173e-05,0.013811674,0.10317361,0.033933554,0.039808992,0.05327333,0.036215138,-0.041803945,0.024544023,-0.025865555,-0.05215579,-0.07194321,0.05281949,-0.084235005,-0.029813098,-0.033882767,-0.022719283,0.035179183,0.042968586,0.049365707,0.035428304,0.0160017,-0.023739446,-0.018655365,0.04556636,-0.014193677,-0.09404633,0.002501268,0.032758866,0.006639856,0.031401683,-0.013331269,0.01109745,0.006921691,0.017275993,0.058334026,-0.026821785,-0.029236749,-0.06360994,0.06091329,0.058591638,0.054127213,0.11919408,0.038485225,0.052752964,0.090344995,-0.022741657,0.024152681,-0.0019893313,0.057923738,0.088258564,0.04359098,0.068805166,-0.0701012,0.009067893,0.035271917,0.019307623,-0.003978343,-0.014396493,-0.05842267,-0.03689388,-0.039300397,-0.09995244,0.03006368,0.08948822,0.009866911,-0.00039730495,0.0005107835,-0.0038721221,0.014001273,0.078777626,0.029434789,-4.040329e-08,0.024297839,-0.06932157,0.063514166,-0.07395551,0.027286205,-0.00207702,-0.014321122,-0.026193047,0.041211978,-0.034021713,-0.04634223,0.038134053,0.01664739,-0.014575794,-0.039243672,0.07104643,-0.064226195,0.016747888,0.0033012247,-0.029920872,-0.08347857,0.07002096,-0.13442536,-0.0071814856,0.08189073,-0.041949227,-0.0065898793,0.009339892,-0.079927444,-0.018644037,0.021870892,0.013692217,-0.06739203,-0.03563865,-0.051075716,-0.006651985,-0.075463,-0.037805066,0.061011992,0.0026603497,-0.010591514,-0.0083218105,-0.051801298,0.0035157271,-0.05796326,0.048497185,-0.0459672,-0.01005841,-0.07534259,-0.019649584,0.069404125,0.015248955,-0.033165656,-0.074875236,-0.16000037,0.010797198,0.035254054,-0.103338785,-0.0127994595,-0.0760894,-0.087138236,-0.035368934,0.17623621,-0.023754735 +2.8.3.19,"The enzymes characterized from the bacteria Escherichia coli and Acetobacter aceti can also use formyl-CoA and oxalate (EC 2.8.3.16, formyl-CoA transferase) or formyl-CoA and acetate, with significantly reduced specific activities.",384,0.99999994,-0.12837154,-0.071072556,-0.095657915,0.01446111,0.031436857,0.048426412,-0.11465114,0.044353347,0.01699828,-0.05539104,0.023918089,-0.06196974,-0.07529402,0.08485989,0.005146453,0.011243965,-0.024225054,0.05742117,0.058516163,-0.07805641,0.053965434,0.022861242,-0.06790238,-0.02366843,0.029618843,0.002678971,0.020148814,-0.02600783,-0.0047413893,-0.07241877,0.0062223803,-0.039857775,0.067749925,-0.077679865,0.04484868,0.024884252,-0.00887992,-0.12609099,0.09167864,-0.004985982,0.016247531,0.010516122,0.007988562,-0.026440285,0.009589088,-0.079365924,0.035290655,-0.018961117,0.012107941,-0.058933347,-0.036669437,-0.019208843,-0.060218755,0.033076864,0.050521765,-0.02674945,0.031708404,-0.12349985,0.008668508,-0.008679111,0.013475303,0.008251792,0.044100452,0.00797067,-0.08634807,-0.07542558,0.053295773,-0.025546998,-0.023909487,-0.03889297,-0.10131668,-0.017508322,-0.042712037,0.10126112,-0.0042830105,-0.03764114,-0.012683958,-0.04964528,0.038400088,0.049748987,-0.024460265,-0.011547541,-0.04236207,0.068713866,0.016695129,0.02364046,-0.018261733,-0.012767626,0.0033496106,-0.011722453,0.018577078,-0.030725792,0.031528186,-0.059930746,-0.044740766,-0.013680115,0.033000346,0.0125500355,0.06593533,-0.023863256,-0.034627467,0.07704034,-0.023989195,-0.052897748,-0.014274927,-0.043143492,0.06867238,0.10053199,0.04326008,0.050561532,0.0028189903,-0.078637585,-0.0061865626,-0.04179197,0.0190373,0.040398326,-0.0049184393,-0.050769646,-0.052146077,0.08897004,0.015196776,-0.050041188,0.084067546,0.046793345,0.022714857,0.030404355,-0.07007019,2.0470619e-33,0.063917235,0.057508375,0.023957679,0.0077319737,0.011884991,-0.032323603,-0.10669037,0.028144313,0.055481102,-0.051583152,-0.030973583,-0.039316114,0.03511672,0.037044596,0.033667266,0.02650121,-0.020269495,-0.031953182,0.03463827,0.038078964,0.021643193,0.012328142,0.066645205,0.07765564,0.062793955,-0.029758964,-0.02454426,0.03534554,0.03363075,-0.007506869,0.017102716,-0.07452737,-0.091033265,0.002608083,0.026484868,-0.046058524,-0.044702582,-0.013028886,0.0015323948,0.027345741,0.07400175,0.06241638,-0.036663257,-0.029143322,0.07217925,-0.05608025,-0.036685012,0.11300891,0.029296678,0.059845593,0.016720055,-0.010083778,0.090585165,-0.091923706,-0.02046228,0.07527392,-0.01476342,0.023504892,0.040711105,-0.0021083257,-0.009573342,0.05929841,-0.028441496,0.03521054,-0.027684202,0.039023165,-0.016201694,-0.07451279,0.0014406199,0.035500046,-0.059358537,-0.0126973335,-0.0077635176,0.04176618,0.0500463,-0.10981175,-0.055399936,0.008297761,0.0940679,-0.024206452,0.0194999,0.01864045,0.048982024,-0.013501613,0.030108716,-0.010329146,-0.057587616,0.054592855,0.012233323,0.034674264,0.05478682,-0.046414156,-0.026899897,0.013741701,0.02330327,-3.4490503e-33,0.09139115,-0.08600653,-0.012455693,-0.13895106,-0.06411973,0.04578652,0.015804388,-0.016266499,0.09788334,0.008537352,0.05754636,0.01852524,0.044542596,-0.07054544,0.013520646,-0.035391267,-0.0024429583,0.016604245,-0.045177843,-0.0013237629,-0.009135756,0.0015510925,0.048693933,-0.08033099,0.08039626,0.016439252,-0.1057649,0.04609345,0.021703476,-0.017131278,-0.018781478,-0.009161957,0.017463354,-0.07121526,-0.09208778,0.037054557,-0.011290898,0.0848486,-0.012387942,-0.004040299,0.018797385,0.029701076,0.055141695,0.07757776,-0.0009098369,0.035266597,-0.052557513,-0.038167905,-0.036482535,-0.040906362,-0.010121621,-0.067660026,-0.11011931,-0.041967984,0.028686248,0.06761234,0.0069162846,0.012808273,-0.022067292,-0.055413708,-0.055516418,-0.040116157,0.026569536,-0.019493498,0.047754247,0.079675086,0.002259568,0.02445321,0.04213897,-0.024495643,0.06487335,0.06370782,0.045387547,-0.019106993,0.017175188,-0.042705696,-0.073147304,-0.02185873,-0.004937052,-0.035394788,-0.04488973,-0.025748355,-0.07391342,-0.05433901,-0.046185806,-0.019571433,-0.019073855,0.04011406,0.0024712975,0.050149698,-0.06108751,-0.002400144,0.026465144,0.043834243,-0.015083504,-3.7508652e-08,0.021121684,-0.0341401,0.07924211,-0.05255074,0.035828166,0.025289172,-0.040279005,0.01582391,0.11319669,-0.022347404,-0.013848626,0.13448815,0.031622823,0.010089556,0.019270204,0.0011660584,-0.007493615,0.021011278,-0.02790672,-0.015728276,0.002129762,0.000241586,-0.031134771,0.11487374,0.049955074,-0.089184016,0.034177784,-0.025887355,-0.035203543,-0.028584817,-0.02555466,0.059503324,0.027508754,-0.03451073,-0.047975447,-0.067694634,0.066198796,-0.04223159,-0.05262203,0.097968854,0.06652204,-0.00080782396,-0.16172914,0.0014848019,0.08523548,0.05510089,-0.03122031,0.025478097,-0.026415141,-0.10463455,0.035571616,-0.026260579,-0.04048955,-0.010534487,-0.09637874,0.04648916,0.046125222,-0.086729825,-0.0061814142,-0.011919308,0.04815018,-0.0061051114,0.22124507,0.018951694 +2.7.1.180,"The enzyme catalyses the transfer of the FMN portion of FAD and its covalent binding to the hydroxyl group of an L-threonine residue in a target flavin-binding protein such as the B and C subunits of EC 7.2.1.1, NADH:ubiquinone reductase (Na+-transporting). Requires Mg2+.",384,1.0,-0.09264501,-0.060312893,-0.10536937,0.040514287,0.10698069,0.028740365,0.0030119477,0.07128946,-0.022865476,-0.050549164,0.0049820514,-0.022854675,-0.06495879,0.028227454,-0.05295492,-0.042430934,-0.093188256,-0.006053978,-0.046755496,0.007370913,0.030176496,0.013281934,0.0095836865,-0.020276865,-0.008107452,-0.03225306,0.03956687,-0.0456895,0.012901536,-0.057308916,0.019107364,-0.0019726774,0.039692394,-0.024464058,-0.025111802,0.079393156,0.011057767,-0.07856373,-0.011612259,-0.029811567,0.04655199,-0.049701124,0.112484165,-0.039795592,0.02526237,-0.00010242852,0.041557904,0.09193021,0.05027116,0.11736196,0.0062657148,-0.03910071,-0.08116622,0.09646013,0.037442476,0.06008885,-0.03283271,-0.037398215,-0.044163838,0.023286402,0.00045842578,0.040325385,-0.0276068,-0.021544877,0.088180736,-0.047325533,-0.05933146,-0.05047577,0.013453413,0.027744902,0.041364104,-0.051542796,-0.05193472,-0.021787845,0.04140072,0.047908954,-0.058513854,0.024924638,0.03333457,-0.023061335,0.06997019,0.007888176,0.08604932,0.08864314,0.05236538,-0.051562663,-0.013474858,-0.00522504,0.0041094944,0.0815227,0.046946045,0.024169631,0.0005394244,-0.021367192,-0.11870071,0.05513997,-0.0014429659,0.09373734,-0.02688146,0.037544966,0.02159236,0.09390192,-0.030056076,-0.013393185,-0.12726085,-0.045275267,0.004475084,0.08331442,-0.0044101756,-0.05467091,0.030676832,0.007519374,0.045169067,-0.060502823,-0.058815677,0.044962045,-0.05502173,-0.122988336,-0.07743718,-0.029962987,-0.049957693,0.045802344,0.042789977,0.12972967,0.06324585,-0.065428436,-0.17763002,2.2015986e-33,0.026623145,0.01287483,-0.012465298,-0.053576093,-0.06073252,-0.023880161,-0.05997752,0.019650348,-0.0051499293,-0.040484264,-0.025226409,-0.0077040284,0.05032576,-0.039631926,-0.026151488,-0.06774884,0.005144861,-0.06787106,0.0399429,-0.064243674,0.056379586,0.020449633,0.0016914238,0.013617188,0.025392028,0.058604896,-0.09648968,0.07056158,0.022395004,0.03614539,-0.008394381,-0.08905445,-0.03778435,0.059820227,-0.014345265,-0.015523373,-0.114253625,-0.06306543,-0.056333557,0.087150775,0.041799076,0.018484477,-0.091453254,0.02802444,0.057028674,-0.06597793,-0.047626544,0.12589155,0.037143987,0.07577616,0.06502779,-0.039626833,0.04524513,-0.038182255,-0.06553263,0.038996417,-0.0657605,0.005760983,0.00047086872,0.03596559,0.05128191,0.031280294,0.0011836811,0.1032278,-0.014844668,0.050049234,-0.003673073,-0.08071141,0.024471272,0.074302845,0.009270619,-0.048864283,0.11881245,0.03339121,0.048133302,-0.012214672,-0.026832793,-0.02841493,0.017346622,-0.006344231,-0.034414176,-0.034316335,-0.0604045,0.0153919775,-0.052887745,0.0094783185,0.0049197758,-0.08591141,-0.012784837,0.015929928,0.056813106,-0.06969668,-0.011868122,-0.033832766,0.05732845,-1.9416116e-33,0.032231413,-0.05115305,0.0059784814,-0.049455278,-0.03927145,0.021138709,0.045368087,-0.04430075,0.050854936,0.043160647,0.044403277,-0.043638844,-0.03161479,-0.03618184,0.037719227,-0.010718254,-0.013937229,0.003111473,0.054016247,0.024099622,-0.0035764787,0.016808199,0.03854654,0.0835936,-0.015777076,0.01395531,0.009418865,0.030730065,0.08613568,0.08161253,-0.08144617,0.036936797,-0.061620317,-0.032988157,-0.057149086,0.04454389,-0.0077502937,0.044999707,0.010894478,-0.00059985503,0.047045026,0.009550125,-0.0026471848,0.012118686,0.044094317,0.07405044,-0.06702853,0.045925584,-0.013842418,-0.09457961,0.068844095,-0.002067909,-0.010778051,-0.017637659,-0.028544923,0.079819515,0.050568692,0.0017045168,0.06789103,-0.031336624,0.011121661,-0.09584957,-0.011368509,-0.048029654,0.021673694,0.0014080923,0.0696573,0.11355527,0.0047364784,0.06539196,0.068618044,-0.02207512,0.10225438,0.085891664,-0.017361188,-0.0022917737,-0.0069659967,0.023586605,0.006549735,-0.023216225,0.01854559,0.0044386145,-0.008637256,-0.049013045,0.0127623975,-0.008444139,0.019663345,0.09591909,0.011404802,0.0281769,-0.028370151,0.03345878,0.0053922,-0.02400534,0.018420529,-3.866005e-08,0.012567717,-0.09562835,0.015235266,-0.01038647,0.09309917,0.09931709,-0.0563906,-0.0008262338,-0.029151935,0.020594245,-0.049354874,0.05725419,0.019748978,-0.054561555,-0.0013881184,0.0053119706,0.011210668,0.027451856,-0.07421193,-0.049912356,-0.07213478,0.06899534,-0.0860289,-0.005293682,-0.02161913,-0.03749661,0.01618493,0.02920086,-0.019013315,-0.044590637,0.036255684,0.028579008,0.014008406,-0.038429484,-0.1318787,-0.018690242,0.05147552,-0.047899675,-0.06841538,0.015425462,-0.07541541,0.032579992,0.0046022357,0.009257245,-0.030498086,-0.02187246,0.025010562,0.03218605,-0.041159935,0.01882714,0.056733508,-0.07793896,-0.020462526,-0.07307994,-0.04342612,-0.037902657,-0.031133926,-0.048921272,-0.022168275,-0.059480652,0.0060544736,0.068986595,0.081691965,0.0022824532 +2.7.1.223,"The enzyme, characterized from the bacterium Salmonella enterica, can phosphorylate exogeneously-provided 5-amino-1-(beta-D-ribosyl)imidazole to form 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole (AIR), an important intermediate in the production of both purine mononucleotides and the hydroxymethyl pyrimidine moiety of thiamine.",384,1.0,0.007439323,-0.06517694,-0.0844899,-0.055197358,0.046320803,-0.0035506971,0.07510099,0.04155951,0.021573428,0.0657082,0.03684348,0.018900895,-0.03652723,0.110191286,-0.048711356,0.03095352,-0.055512536,-0.0009726749,-0.034212973,-0.06425022,0.02240059,0.057245366,-0.03466409,0.0069654626,-0.045565907,-0.041064493,0.08022773,0.010030841,-0.04432841,-0.076232575,-0.08650022,-0.09040863,0.117075846,-0.05343209,0.048190717,0.054926362,0.017130962,-0.024469925,0.03940127,-0.0072807637,0.034263745,0.01533446,0.015072078,0.027847923,-0.082511224,0.001128728,0.057048496,0.105254054,0.09165633,0.03239829,-0.11375302,-0.014548181,-0.022431955,-0.047622003,-0.048058286,0.063238576,-0.059979167,-0.07804704,-0.053622954,-0.008965014,-0.0010657553,0.019908775,0.06403371,0.022500716,0.012632418,-0.06499001,0.00407108,-0.02200577,-0.024576241,-0.048782725,-0.04021934,-0.07515063,-0.0016107955,0.009694983,-0.028868241,0.0030894452,0.03223367,-0.06099588,0.053115353,0.04361723,-0.049245924,-0.059016664,0.008332212,-0.024340082,0.031092647,0.066061415,0.03103862,0.059405074,0.08133701,0.044480063,0.011386774,-0.003034713,0.05747254,-0.052073203,-0.01981834,0.014885425,6.0508417e-05,0.031465612,0.021605745,-0.04542065,0.030466985,0.010295028,-0.03707308,-0.06448166,-0.0066037322,-0.027082827,0.04525422,0.008608382,-0.028785432,-0.0064701135,-0.07491024,0.027932948,0.034123514,0.0095075695,0.03898356,0.04233324,0.009234935,-0.053990778,-0.03714208,0.0017171979,-0.032249738,-0.02796361,0.040187716,0.034473017,-0.09495323,0.026033958,-0.056316096,1.0110134e-33,-0.015160753,0.054084644,0.06500464,-0.016553773,0.021389151,-0.0058242567,-0.04336867,-0.010082071,-0.04761114,-0.023529101,-0.15086704,-0.09509269,0.029403614,0.005216246,0.0045496398,-0.042835776,-0.053530354,0.09859025,0.026750326,0.07274508,0.009616017,0.024700921,-0.012720857,-0.008261529,0.028664125,0.07455956,0.022273902,0.059499033,0.10498633,-0.026933474,0.000674455,-0.06668447,-0.1287614,-0.045298006,0.03928637,-0.050263543,-0.046890438,0.06128656,-0.009733976,0.034618456,-0.004727951,0.014956137,-0.055994645,0.027506454,0.026882954,-0.048295993,-0.057723597,0.06965099,0.04607601,-0.011882298,-0.004440187,-0.0027024467,0.101026826,-0.06963081,0.0048394655,0.01997656,-0.007701123,0.022272564,0.059399497,-0.002174627,-0.07431779,0.024307976,-0.04362649,0.054757487,-0.018654365,0.009711209,-0.0056061484,-0.042738996,0.096369624,0.07840802,0.012438312,-0.044807453,0.0034404881,-0.005480827,-0.0036927965,-0.07984814,-0.10933117,-0.055444706,-0.014726305,-0.008418934,0.018994223,0.027494162,-0.0005001262,-0.00032794898,-0.037712634,0.06133096,0.03895094,0.005953375,0.011853547,0.05548718,0.0967724,-0.06961341,-0.032684032,-0.013803812,0.021310043,-2.0647553e-33,0.117226586,-0.09551921,0.002928366,-0.09063094,-0.05631327,0.012008208,0.028652426,0.0028115185,0.053584415,0.010322246,0.03450688,0.036724728,-0.010942954,-0.035442095,-0.048734322,-0.021670373,0.0744942,0.078508094,0.021274496,-0.06175324,-0.037624463,-0.030963404,0.031296708,-0.015129812,-0.019525312,0.050406046,-0.02483949,0.06798486,-0.024703348,0.040123835,-0.041448526,0.076769955,-0.0043658516,-0.009620886,-0.0073138946,-0.006259902,-0.0429162,-0.041823525,0.052419983,0.010740438,-0.055337414,0.092178345,0.020720435,0.0532179,-0.041131303,0.08155617,-0.06975064,-0.005329097,-0.03340212,-0.07581452,0.021185866,-0.022799866,0.0052056005,-0.015363683,0.057107188,0.020662632,-0.033329837,0.064800166,0.0010340887,-0.0076417513,-0.057435676,-0.117131226,0.055831183,-0.068129204,0.06405231,0.021691104,-0.018588426,0.042116504,0.004593328,-0.008174624,-0.025956206,0.06714247,0.013104526,0.045563996,-0.020696534,-0.063352615,-0.0019191856,0.017804703,0.049092807,-0.023955626,-0.021197122,-0.023497794,-0.08508745,-0.07355931,0.0020979152,-0.098710954,0.053400513,0.049970258,0.0034746525,0.08241641,-0.008028374,-0.010605471,0.0031414486,0.049938355,0.06364833,-4.2145118e-08,0.08255379,-0.08521571,0.007123143,-0.07188527,-0.028520402,0.06725735,-0.044458274,-0.039353162,0.17746447,-0.06409446,-0.010570533,0.049690343,0.10305743,0.07660354,-0.015484662,0.033295315,-0.075268306,-0.05792633,0.029111898,0.005914967,-0.041061584,0.059110906,-0.16677172,0.03017624,0.084480286,0.013255432,0.017906513,-0.037805382,-0.043055035,0.025068944,-0.060798008,0.0023977992,0.027190795,-0.06024503,-0.04232836,0.04307878,-0.011991024,0.022784658,-0.06515535,-0.01878511,0.031799745,-0.0017707129,-0.09974885,-0.016781641,-0.0048180087,0.017910102,-0.059025627,0.106799856,-0.04946111,-0.066957004,0.026132427,0.04188792,0.042942375,-0.06282279,-0.06448832,0.017370367,-0.0008831137,-0.09326119,-0.035255108,0.0058528297,0.049310286,0.04790972,0.15159795,-0.008699239 +3.2.1.187,"The enzyme, which was identified in the bacterium Bifidobacterium longum JCM1217, is specific for (Ara-f)3-Hyp, a sugar chain found in hydroxyproline-rich glyoproteins such as extensin and lectin. The enzyme was not able to accept (Ara-f)2-Hyp or (Ara-f)4-Hyp as substrates. In the presence of 1-alkanols, the enzyme demonstrates transglycosylation activity, retaining the anomeric configuration of the arabinofuranose residue.",384,0.9999999,-0.05215377,-0.049438436,-0.095879234,-0.019377334,-0.0027224103,0.013713771,-0.071475275,0.03542488,-0.010509075,-0.024183102,0.016512698,0.0093709165,-0.07990035,0.0004943171,0.0055902563,0.0368939,-0.078825586,0.027378377,0.0048031127,-0.030716596,0.14320004,-0.040436383,-0.04022567,-0.017288076,-0.02094258,-0.009143223,0.061257105,-0.01022342,-0.06508696,-0.034261703,-0.03373213,0.0152442185,0.08407492,-0.047439527,0.031685125,0.07775975,-0.05099966,-0.08295802,0.0861703,-0.008331232,0.061431188,-0.0062812935,-0.008359454,-0.038380012,-0.07638645,-0.039129686,0.070003234,0.024549123,0.08784354,0.03770501,-0.07956214,0.018817138,-0.077875264,0.0060874643,0.05508483,-0.07159054,-0.004733892,-0.012946693,-0.0031550224,0.03452508,0.00685473,0.019387165,0.05170334,-0.02182307,-0.047149137,-0.07591445,0.055166516,-0.06155965,0.01303331,-0.021643786,-0.09416605,-0.023733236,-0.03277968,0.009946585,0.035233386,0.024449348,-0.04365277,-0.036149826,-0.008808826,-0.050658368,0.052861854,-0.062480442,0.06366031,0.04406923,-0.029390542,-0.07791636,0.05153993,-0.018202081,-0.011320345,0.035297126,0.0880658,-0.022843953,0.016405923,-0.0898812,0.024282178,-0.0070628296,-0.01864503,-0.044534698,-0.0048926636,-0.026289135,0.014324889,0.018382974,0.097078964,-0.030055365,-0.05165905,0.072635144,-0.037539784,0.1265565,0.07746734,0.016463395,-0.005216052,0.017292762,0.07941384,-0.039046004,-0.07312802,0.042335622,-0.060030293,-0.096137874,-0.05824848,0.05141524,0.0010867111,-0.03555808,0.087330654,0.06599913,0.014990255,0.079271235,-0.06715965,2.3550686e-33,0.10328607,-0.013115785,0.016294936,-0.06353438,-0.03204461,-0.017533384,-0.06741044,0.016663162,-0.06122235,-0.00029774528,-0.012276332,-0.07399251,0.054279767,0.068297744,-0.08896266,-0.0019999088,0.007883391,-0.029858027,0.04687292,0.0549806,0.0064932597,0.019937854,0.031007081,-0.03179428,0.07755756,0.07251219,0.002116754,0.017718349,0.054638118,0.012247308,0.020083483,-0.089831896,-0.12289894,-0.012850232,0.065135226,-0.022867143,0.010260739,-0.030771486,-0.042275853,-0.009073444,0.065170676,-0.017821692,0.06064841,-0.03980188,0.05607927,0.043762106,-0.029918294,0.09554783,0.030995367,0.14831145,0.0032701262,-0.01724542,0.045134373,0.011187552,-0.028005522,0.016920896,0.014380154,0.03647074,0.039012168,0.014270885,-0.0072784647,0.068712875,-0.040737048,0.011953423,-0.01491698,0.025850877,-0.051884778,-0.010377664,0.040983163,0.001257521,-0.009188649,-0.021679876,0.085920654,0.0833402,-0.025258072,-0.026406813,-0.09035188,-0.04233137,0.052805506,0.0007140332,0.0148159815,0.037455224,0.0698261,-0.03787102,-0.11639665,0.03186598,-0.0730954,-0.08669484,-0.026321754,0.02058995,0.016992882,0.022854095,-0.06396959,0.05675437,-0.020852294,-4.138673e-33,0.121961676,-0.12077982,0.016476402,-0.028553752,-0.02245494,0.013383717,0.031421766,0.086424455,0.0051169847,-0.0015167135,0.13408954,-0.036829714,-0.0007945302,-0.1092217,0.10684656,-0.0028479362,-0.043330006,0.05944214,-0.037800923,0.01765834,0.01216186,0.011368644,0.024827227,0.030321475,-0.0022486292,0.011439379,0.0250075,0.03131505,0.00467073,0.070482984,-0.014675551,-4.2132873e-05,-0.09988555,-0.06904159,-0.029671839,-0.0095556835,-0.086827844,-0.0023152225,0.0074577937,-0.0062013967,0.019427048,0.063591525,0.046300653,0.0012250355,0.04055722,0.03171194,-0.041032396,0.0676761,0.06972112,-0.09203742,-0.04413117,0.0013920191,0.034801148,-0.0037964368,0.013633017,0.055376224,0.026409099,0.08182864,-0.0712956,0.011467954,-0.08731328,-0.071787484,0.09016492,-0.030789752,0.07044987,0.089813225,0.01715305,-0.045564823,0.099263325,-0.03494986,0.061069775,-0.0008153563,0.0020800962,0.06442565,0.033709377,0.034384925,-0.09695726,-0.06420043,-0.050931692,0.01895394,0.07031363,-0.01979468,-0.08957063,-0.019057317,-0.02868889,-0.060349867,0.012745617,0.04031827,-0.0261663,-0.009676626,-0.014730031,-0.053048488,-0.041023154,-0.017804673,0.04337948,-4.182777e-08,0.007304153,-0.010019556,0.06273153,-0.033433214,-0.008660474,0.075729184,0.01198606,0.022441711,-0.008844203,-0.0045753275,0.0021218127,0.06711811,-0.074624516,0.057668135,-0.012468932,-0.02221221,-0.06568427,0.016799796,-0.015781928,0.0055652587,-0.10858783,-0.04288664,-0.13135909,0.0337525,-0.0004936913,-0.05641288,0.00917598,-0.0049364166,0.020571819,0.015603259,-0.025846103,0.020949602,-0.030382121,-0.0028295922,-0.05488176,-0.089701846,-0.06258903,0.0203823,-0.04555701,0.028454479,0.09198207,0.008342139,-0.074560344,-0.04539981,0.021532767,-0.00016811151,-0.0006358127,0.056463946,-0.07085664,0.0061083417,0.07737008,0.03574804,-0.05426408,-0.042748768,-0.04486069,-0.002643801,-0.015732536,-0.052219078,-0.0030544177,0.011944586,0.0318437,-0.028535822,0.123356216,-0.035479616 +3.2.1.188,Isolated from oat (Avena sativa) seedlings. The product acts as a defense system against fungal infection. Also acts on avenacoside A.,384,1.0,-0.023113916,0.012342965,-0.14388345,0.028747214,0.09643863,0.011330708,-0.04261787,0.026607111,0.032689527,-0.025606707,0.11225725,0.014021218,-0.06910646,-0.030171908,-0.09979931,0.016544314,0.01914267,-0.0005670943,-0.013180363,-0.037602425,0.012651679,0.06044078,0.029694477,-0.013052827,0.0074520158,-0.015584693,-0.061551243,0.054807186,0.034461625,-0.1317718,0.030572202,0.009776371,0.04621759,-0.04548211,-0.011577745,0.016874807,0.03178188,-0.016042693,0.010417163,0.0032913575,0.03392114,-0.041433174,0.0041288054,-0.0079840515,-0.048601277,-0.040545274,-0.05133527,0.007987148,-0.0032578523,-0.048354592,0.012958021,0.0082134325,-0.04837583,0.045445926,0.008846226,-0.0083954865,-0.024053244,-0.014102736,-0.006696626,0.07125966,0.066561855,0.031860583,-0.06099186,0.027775893,-0.085440375,0.009247084,-0.041040104,0.025482377,0.04085503,-0.033377506,0.044327892,-0.027174076,0.020282866,0.036679994,0.017130297,0.075835206,-0.013227098,-0.06989264,0.06293525,0.02461014,-0.029398436,0.052461803,-0.015614926,0.06751934,-0.023420123,-0.009874144,-0.039971616,0.058451727,0.05822908,0.0016833338,0.049418215,0.018691108,0.01846887,0.03997614,0.038322974,0.010479221,0.071652696,-0.056023423,-0.080882534,0.012565518,-0.026382115,-0.059872188,-0.02476928,-0.04629323,-0.063860305,0.04313167,0.008522013,-0.11999162,0.07163863,0.0077017713,-0.044403017,-0.011581636,-0.105465315,-0.018253675,-0.080074124,-0.043933153,0.04062125,-0.0292374,0.018970292,-0.10053151,-0.05847451,0.017048806,0.037285145,0.016138278,0.050830796,0.0046602204,-0.06367593,6.0607254e-34,0.015178084,-0.01579541,-0.014383918,-0.05202489,0.09181158,-0.023518996,0.009079545,-0.017796502,0.02837457,0.0059175054,-0.12228672,-0.02171449,-0.03904902,0.08899111,0.05068689,-0.016304605,0.0068391534,-0.060002834,0.012497334,-0.0070328666,0.010218297,0.08696451,-0.08962389,0.031618997,0.015696162,-0.060150515,0.028260235,-0.038715947,-0.010252845,0.002909389,0.037536312,-0.04519468,-0.06836443,0.030094063,0.08972227,0.04494688,-0.061533704,-0.044465628,0.009738885,0.031539768,0.020441527,0.037726533,0.073225334,0.002075208,0.051037613,0.0129577,-0.054408282,0.07263339,0.09556605,0.0062211985,0.06196261,0.003756876,0.010870316,0.01254015,-0.070942886,-0.019900223,-0.08354952,0.065772094,0.087764375,0.04232724,-0.04532544,0.04159167,0.025853952,0.015464387,-0.046241373,0.013986039,-0.12954526,-0.036859285,-0.018020788,-0.0072747697,-0.01891299,-0.021835057,-0.052453604,-0.09758469,-0.021619823,0.009889467,-0.020981923,0.104090124,0.024617195,0.0028704589,0.035899762,-0.06889305,0.037555095,0.025942646,-0.09971915,0.028624319,-0.03417433,0.09072908,0.05199257,0.059376232,0.1020889,0.03724793,-0.04039156,0.03966973,0.0047993953,-1.6855726e-33,0.041572828,-0.05564112,0.10471631,-0.023193993,-0.026879152,0.09632096,-0.062119197,0.024938107,0.021905636,-0.023753054,-0.038163297,0.05279343,0.11404682,-0.06983479,0.0007708877,0.036997955,0.030598523,0.12342558,-0.0042003044,0.033756316,-0.13780102,0.07472297,-0.036187258,-0.050931636,0.046008755,-0.007240736,0.072109036,0.020116564,-0.038924884,-0.035434235,0.082109705,-0.02498691,-0.061061908,-0.074081026,-0.03185845,0.03916732,0.059317414,-0.09006879,-0.07564579,-0.0134168975,-0.026213009,-0.004917902,0.02087419,0.07148894,0.062270503,0.07547895,-0.04837618,0.031791504,-0.07969548,0.004255826,0.06307265,-0.017008146,0.060877454,0.0045377365,0.048670236,-0.07697654,0.027737947,-0.006299802,0.0031652334,-0.04742101,0.060735222,-0.006336987,-0.06392218,0.0043147495,0.0392896,0.04810291,-0.005063102,0.022388848,-0.022151688,-0.011515543,0.07659258,0.06479982,-0.009998538,-0.024312926,-0.013823558,0.0121936,0.0074154795,-0.052240375,-0.011986012,0.00959944,-0.019874588,-0.07028887,0.042787522,-0.016543109,-0.088785194,-0.034068618,0.07148988,0.060722575,0.018324545,0.08269379,-0.020248685,0.034185093,-0.10754723,0.077285476,0.14143482,-2.3956602e-08,0.037465055,-0.040661026,-0.017996758,-0.03693549,-0.087545745,-0.05882615,0.06275106,0.051859606,0.04171252,0.027764909,-0.068997025,0.057523593,0.032831576,-0.014590061,0.043696746,-0.034138147,0.04470331,0.025711933,-0.012571321,0.047358204,-0.0495622,-0.019144623,0.014135142,-0.016065598,-0.06251144,-0.052831266,0.098540075,-0.01803727,0.07677041,-0.030618288,0.030686088,0.056069624,-0.011283722,-0.07452545,-0.057120804,0.08674561,0.0488897,-0.07159102,0.05502102,-0.009944035,-0.04484193,-0.04293967,0.031852204,-0.0193595,-0.075109065,-0.049709942,-0.020415632,0.014245291,-0.012545331,-0.0896736,0.040039983,0.019890878,0.0142037,-0.037990794,-0.07745933,-0.1166388,-0.025920045,-0.035309047,0.027501702,-0.04567189,-0.066500604,-0.043200918,0.08591716,0.060218435 +3.2.1.189,"The enzyme is involved in degradation of the steroid saponin dioscin by some fungi of the Absidia genus. The enzyme can also hydrolyse 3-O-[alpha-L-Ara-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin into diosgenin and free sugars as the final products. cf. EC 3.2.1.190, dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming). ",384,0.99999994,-0.070713885,-0.011632346,-0.10240538,0.00490499,0.054519676,-0.08394646,-0.003650003,0.09658873,0.019993497,-0.008971097,0.08400506,0.08724254,-0.049023002,0.029386021,-0.061661646,0.0028778724,-0.018533142,0.07514035,-0.04766189,0.0005933911,0.11463299,-0.010889898,-0.07147694,0.04540478,0.0877692,-0.0726061,0.03392183,0.034929805,-0.0044545378,-0.053950287,-0.016365087,-0.029427946,0.0772653,0.026865324,-0.017532434,0.13189168,0.008455724,-0.07660368,0.09726365,0.020795973,-0.021445813,0.007593934,-0.004670815,-0.018642616,0.006382201,-0.035158522,-0.07715437,0.030984866,0.08649865,-0.009781049,-0.01729308,-0.03412705,0.008588203,0.031865355,0.039218985,-0.032724753,-0.05718111,0.030742476,-0.070142075,0.037148967,0.04273952,0.013870918,-0.017361447,0.00231434,-0.112315886,-0.019357473,0.019748958,-0.015237901,-0.010161552,0.01131118,-0.03789726,-0.022153687,-0.030100914,-0.017277554,0.017338714,0.07344618,-0.048635338,0.015781356,-0.065931894,-0.080807775,0.1314633,0.02283318,0.035608135,0.06384894,-0.01744172,0.028470626,0.037279665,-0.004390181,0.029489478,0.04729738,0.020806752,0.049438745,-0.00454648,-0.05695028,-0.027654309,0.03931095,0.026889225,-0.0038755652,-0.026743684,0.022623178,-0.06019935,0.015762005,0.0049583693,-0.04254401,-0.103042476,0.04203354,0.0135546625,0.015317339,0.030927954,0.006857441,0.009583653,0.011410272,0.036005396,0.02943797,-0.071116515,0.04858766,0.022419898,-0.044801284,-0.06292201,-0.025639785,-0.013201936,0.015507564,0.0105094155,0.034768373,0.019763347,0.07733056,0.07360751,-1.1783951e-33,0.009327726,0.06362476,-0.08656137,-0.02936904,0.027157338,-0.018936167,-0.06932076,0.028294316,-0.030250251,-0.029946262,-0.058729462,-0.033159956,-0.029059183,0.04037462,0.029543215,0.022281285,0.12607087,0.0349209,0.054633528,0.051825974,0.010054067,0.0040166383,-0.07656127,-0.058934007,0.036664244,0.105128326,-0.042342987,0.025207756,0.04690341,-0.043446288,0.046644654,-0.05425927,-0.022512926,0.036728602,0.04871191,0.005486239,-0.081180595,-0.030779261,0.02511832,0.045715246,0.011031199,-0.00029045503,-0.013053849,-0.006462663,0.020871183,-0.018026602,-0.023152562,0.043360133,0.082950406,0.030665595,0.028928015,0.043897267,0.042350404,-0.0074255127,-0.02753001,0.016553218,0.030032279,-0.049256228,0.051908705,0.033528656,-0.0028848094,0.044869464,-0.075402744,-0.023488423,-0.043633237,0.02205858,-0.116285056,-0.05680952,-0.0013873298,-0.012071991,-0.032975584,-0.098878466,-0.056188203,0.024123466,0.008894368,0.023721531,0.03861557,0.03298111,0.0051649106,-0.008381383,-0.054728627,0.056842513,-0.00038578617,-0.04958284,-0.034552716,0.102986366,-0.011244281,-0.054403003,0.011772703,0.048562154,-0.01982891,-0.05656708,-0.07003539,-0.013850048,0.057541195,-6.1253913e-34,0.06366666,-0.065342166,0.055701718,-0.06084625,-0.013705372,0.10352637,-0.0772113,0.03942486,0.047378488,-0.021972751,0.00833501,-0.051189408,-0.06584061,-0.041982476,0.00043735432,0.0256913,-0.033504803,0.09923914,-0.081977375,-0.033971567,0.035985954,0.16297917,0.06213371,0.010566608,0.050225403,-0.04169019,0.06424012,0.10995481,0.024212752,0.0497174,-0.002070638,-0.047095414,-0.0054653077,-0.00023275538,-0.028583143,0.060396522,-0.061021738,-0.03588134,-0.018784508,0.01499851,-0.03264112,0.0003100113,0.017141538,0.0017094796,0.06274239,0.08191664,-0.06053492,0.066989146,0.010707115,-0.0050650546,0.07829638,0.021447435,0.00895794,0.04709385,0.023805402,0.03999353,0.009962199,0.061175767,-0.019446328,-0.063255616,-0.0010640738,-0.11152111,0.004675016,0.038299136,0.059183527,0.07977868,-0.013714946,0.03756265,0.021192709,-0.031862136,0.041844036,-0.027035322,-0.043146748,0.046380162,-0.030631,0.008882319,-0.12485291,-0.043247897,-0.0053503015,-0.010838504,-0.0621943,0.028851803,-0.05334426,-0.039812885,-0.047043912,-0.042722594,0.027903313,0.06901731,-0.018104156,0.022817785,0.006383207,-0.020976251,-0.056554466,0.04252184,0.08428082,-4.2237232e-08,0.063448526,-0.031721983,0.017898733,-0.078336164,-0.015544268,-0.052101802,0.010460969,0.028794674,0.052213434,0.01689016,-0.06811048,0.12918992,-0.07149998,-0.023188725,-0.029953869,0.03947347,-0.04561207,0.024333263,-0.006105327,0.031105768,-0.016956065,-0.040236916,-0.103432626,0.04473697,0.011997017,-0.08765952,0.034686383,0.02626343,-0.0581535,0.015293287,0.093958676,0.00991606,-0.0027110523,-0.045594364,-0.049170826,-0.019116962,-0.11356871,-0.019810155,-0.0052334084,-0.017824316,-0.030710703,-0.024806818,-0.023788631,0.016018363,-0.09241299,-0.013071445,0.03927504,0.010255741,-0.02864524,0.015863778,0.07001304,-0.024124011,-0.029591424,-0.10060267,-0.12270626,-0.08497428,0.06121872,-0.015088686,-0.053826258,-0.039107528,-0.03248709,-0.020329978,0.24759226,-0.0070875864 +3.2.1.190,"The enzyme is involved in the hydrolysis of the steroid saponin dioscin by the digestive system of Sus scrofa (pig). cf. EC 3.2.1.189, dioscin glycosidase (diosgenin-forming). ",384,1.0,-0.029533392,-0.009009112,-0.09142651,0.024050372,0.054691654,-0.017445587,-0.04882239,0.11028373,-0.00018441817,0.0132610565,0.08643684,0.051605407,-0.029871693,0.05581532,-0.07649806,-0.04276726,-0.03173474,0.05025398,-0.0009563356,-0.030668896,0.10827575,-0.0071412995,-0.08565249,0.027964536,0.084423564,-0.034488216,0.024675043,0.026104866,-0.028480466,-0.008561448,0.0031290124,-0.03498244,0.06005133,-0.020700963,-0.013553404,0.07719127,0.030025622,-0.05827961,0.12518336,-0.009106581,0.00041039204,-0.046264365,-0.03528668,-0.034090746,-0.0008983502,-0.04019852,-0.045144115,0.046514336,0.07554546,-0.011632745,-0.062199052,-0.027856296,0.01712483,0.031124242,0.01780016,-0.016006907,-0.066851415,-0.025727652,-0.026091186,-0.027751908,0.021191224,0.0037932699,-0.016045803,0.023815673,-0.01792683,-0.047304373,0.018417329,-0.009035465,-0.024065197,0.00051849993,-0.04185319,-0.01806654,0.020283964,0.0017342286,-0.029399153,0.03528784,-0.050782762,0.020820638,-0.01406179,-0.06717932,0.14488691,-0.007885643,0.014965261,0.060364768,0.027219266,0.057917554,0.04812485,-0.02104687,0.025890987,0.06016628,-0.019761408,-0.05919499,-0.03786944,-0.1041226,-0.0016832567,-2.6914162e-05,-0.05549261,0.05281528,-0.0181568,0.020972881,-0.04027101,0.029448196,0.032544523,-0.052313898,-0.050926898,0.054013386,-0.011235516,0.043868747,0.0058442256,0.03246622,-0.0017641522,-0.0039227535,0.008688983,0.012611932,-0.0018392818,0.10944491,0.06074307,-0.07109362,-0.098633744,-0.039875228,0.06929007,0.008353843,0.0116733,0.06498102,0.0026406134,0.076442055,-0.0042971172,-4.6374524e-34,0.018438688,0.028784305,-0.046007052,-0.045434833,0.0069106496,-0.022210231,-0.094593115,0.08031233,-0.04155086,0.0111555215,-0.082907416,-0.0086394455,0.052817143,0.0016219735,-0.01602433,-0.03911555,0.069434,0.034915376,0.08980247,-0.0125207435,-0.0015652576,-0.014714126,-0.055425763,-0.056122497,0.024844054,0.035601318,-0.06584134,-0.025277123,0.059975326,-0.02517828,0.014062487,-0.07738166,-0.0023373796,0.050767872,0.042904668,-0.03311724,-0.047282014,-0.079615824,0.061590865,0.041471433,0.09777275,-0.040421244,0.008412392,0.015801543,-0.018181358,-0.015523854,-0.063322954,0.0444525,0.12935159,0.036022056,0.072215565,-0.01886357,0.052059174,-0.033930525,-0.028949196,0.032193355,0.031790327,-0.057494637,-0.012023667,0.06422641,-0.053769536,0.035967708,-0.10950528,-0.01776991,-0.02712064,-0.008304899,-0.1164534,-0.050394688,-0.004612681,-0.0008786995,-0.13551465,-0.056116845,5.960622e-05,0.01714463,-0.034614224,0.030007515,0.029382033,0.082422204,-0.017328963,0.008386428,-0.06728056,0.04859035,-0.039307125,0.005490666,-0.01668725,0.10551026,-0.039798763,-0.084669404,-0.00034514978,-0.034256868,0.015581542,-0.07809095,-0.08320595,-0.0068457415,0.06150315,-1.6538655e-33,0.027150784,-0.050577164,0.0914622,-0.04678545,-0.02331436,0.13151649,-0.0083803935,-0.010484891,0.042337075,-0.027176209,0.0047760415,-0.042577744,-0.014777498,-0.05977808,0.051657606,0.03312986,-0.008653806,0.022074359,-0.044852115,-0.05991088,-0.01651676,0.17199373,0.101997375,0.014867718,0.07167773,-0.011356596,0.085246995,0.07240281,0.020431345,0.103817806,-0.009836324,-0.0637111,-0.027698642,-0.005101536,-0.0066488017,0.04557596,-0.09555427,0.014941509,-0.020643745,-0.01916192,-0.03283132,0.020366129,-0.0020997056,0.047512677,0.036946673,0.0820083,-0.055699855,0.053951707,-0.011913778,-0.017646896,0.07492887,0.020962028,-0.025306124,0.051647563,0.019702457,0.07702214,0.007296602,0.0153879,-0.04194406,-0.08703178,0.020398084,-0.048062686,-0.010117861,0.017271832,0.045470785,0.014351494,-0.053156637,-0.019268332,0.022618713,-0.05353646,0.015093632,-0.029291093,-0.03783198,0.050712798,-0.0063059404,0.038891718,-0.1566138,-0.055275433,-0.00068241,0.01555375,-0.092318825,0.05520247,-0.033717923,-0.030776188,-0.0019256346,-0.0406404,-0.020030834,0.12873617,0.06663394,-0.012167848,0.0029958042,-0.0020606795,-0.04964826,0.036269404,0.065058485,-3.1254547e-08,0.009004485,-0.053620417,0.031839434,-0.025714299,0.001204631,0.0013670643,0.014753302,-0.04493201,0.060608223,-0.00303355,-0.07372156,0.093326576,-0.037715558,-0.057883754,0.00056686817,0.063822545,-0.04715409,0.05434305,-0.01859786,0.018243235,-0.0071994425,-0.07454332,-0.07765435,0.052750964,0.0506529,-0.08440813,0.0032318577,0.036347568,-0.054617334,0.012528365,0.07635306,-0.03586635,-0.036266357,-0.03098884,-0.033633966,0.034069896,-0.051215563,-0.029298007,0.006009807,0.012383411,0.020358598,-0.017581956,-0.009280567,0.04110098,-0.110044815,0.05684959,0.026375065,0.052091625,0.003948046,-0.005149889,-0.005985642,0.00098292,-0.035058256,-0.027553543,-0.07227178,-0.0770336,0.03245609,-0.057369627,-0.014978713,-0.014687321,0.014086929,0.06488966,0.23874243,0.014683912 +3.3.2.13,The enzyme found in several bacterial species is involved in the biosynthesis of macrocyclic polyketides.,384,0.99999994,-0.050227005,0.0009010875,-0.062132988,-0.017375134,0.01714984,-0.0040905634,-0.06076479,0.042609155,0.061980277,-0.015640823,-0.059459016,-0.09767551,0.043258984,0.008878364,-0.062142536,0.034948032,-0.09280271,0.055060126,0.027205145,0.051593732,0.11572635,0.0027958537,-0.019087333,-0.004196882,-0.038422506,-0.03848981,0.088378035,-0.08388051,-0.07975193,0.024431216,0.024334585,0.02884342,0.01742953,-0.06429085,0.115554996,0.11113785,-0.07779864,0.02303076,0.09008939,-0.0052846484,0.056266464,-0.00156669,0.024385061,-0.07302615,0.01835095,0.054276884,-0.010427015,-0.02298644,0.052137993,-0.00766712,-0.06572037,-0.007841398,-0.019434944,0.028093645,0.0538656,-0.054420285,-0.062250637,-0.031004371,0.025597727,-0.059411697,0.07418002,-0.052664094,0.024880396,0.041449167,-0.10033717,-0.02977831,0.024204832,-0.017862985,-0.027717836,-0.0092359595,-0.11288159,0.0010887426,-0.033992317,0.01443262,-0.00072992523,8.404808e-05,0.033938605,-0.00706048,-0.053071927,-0.01028825,-0.002568491,-0.029955773,0.05743331,0.08047304,0.060010437,0.07025407,0.10095418,-0.0017389794,0.032436132,0.105340295,-0.003880856,-0.020158939,0.06901018,-0.051897433,-0.041671757,-0.06811442,-0.011962466,0.042417232,0.084739216,-0.016274234,-0.053307116,-0.04669874,0.014167384,-0.037707277,-0.07026785,0.02831374,0.023690412,0.040269565,0.08720517,0.023298109,-0.03822555,0.029756468,0.024360506,-0.054804705,-0.041230846,0.099646315,0.06755337,-0.016959002,0.029005907,0.020960959,-0.00885961,-0.042560346,0.019207636,0.031189013,-0.023607835,0.018214915,-0.09225256,-1.0521116e-33,0.009801251,0.028684808,0.05154227,-0.067782536,-0.028077278,-0.024374891,-0.03828661,-0.057442375,-0.033353996,-0.10844942,-0.11234516,-0.09227929,-0.0153575875,0.0971198,0.052100077,0.037081834,0.054139715,-0.018194765,0.03424603,-0.030869512,0.001104951,-0.007249689,-0.029789058,0.036110282,0.0032464038,0.022501815,0.054621685,-0.01876359,-0.019249251,-0.019888872,-0.03102933,-0.051605817,-0.045929227,0.09050036,0.059415,0.08397178,-0.010527462,-0.011676707,0.0048183184,0.00646902,-0.051887836,-0.03696859,-0.016753752,-0.07511763,0.06717712,0.017972387,-0.06434571,0.03260516,0.0017605042,0.08160043,-0.011036594,0.05250584,0.07177282,0.04244173,-0.076713994,0.0435606,-0.04395356,-0.035932638,-0.013943989,0.013870156,-0.011369764,0.03078943,0.017162513,0.026647074,0.0006243707,0.031453524,0.0065864893,0.020830212,-0.050286517,0.018085333,-0.04496178,-0.013591754,0.053580116,-0.009921242,0.06635635,0.035170145,-0.12416373,-0.052381657,0.020910807,0.031127494,0.008537945,-0.04205846,-0.0029234823,-0.05196756,-0.05619905,0.015200027,-0.008743287,-0.017725177,0.011374585,0.050043337,0.03668965,-0.1829513,-0.032366052,0.080973126,-0.09278968,-2.6283143e-33,0.052412823,-0.032525793,0.05795738,-0.04779527,-0.052024953,0.046524893,-0.031517763,-0.034837957,-0.057578605,-0.057917543,0.0075039193,-0.015625644,-0.03545308,0.02444693,-0.026649043,0.022923222,0.05391859,0.08251338,0.005132003,-0.06776399,0.033025585,0.025198616,0.0007154596,-0.04558955,0.017639833,0.015898818,-0.015677784,0.124300875,-0.0072576627,0.039979294,-0.077393,0.035020918,-0.0032603664,0.015243623,0.035166476,0.08286713,-0.07389265,-0.036114834,0.073506095,0.078074396,-0.029678429,-0.03783701,-0.039528716,0.0453256,0.048085045,0.062279142,-0.022306161,0.022177327,0.076983385,-0.08365136,-0.0020088074,0.06691155,0.09825077,-0.010228621,-0.0060378877,0.058683395,0.011951734,0.058308993,-0.033055693,-0.073556945,-0.03795239,-0.048154958,0.08494887,-0.0093988525,-0.027252648,0.06829344,-0.010990637,-0.015951281,-0.0036140247,-0.028851394,0.032453127,0.026871657,-0.010067872,0.07863609,-0.036448814,-0.04883645,-0.05645536,-0.076005094,-0.032988213,0.024100754,-0.00010684655,-0.0051031965,0.023996385,-0.047279473,-0.06323019,-0.072025344,0.073313594,-0.06408889,-0.00048932876,-0.0040953034,-0.017996505,0.07803387,0.009233056,0.11572054,0.039902415,-2.8029595e-08,0.07277093,-0.051777046,-0.041936778,-0.04574826,-0.012352291,-0.015832065,-0.07389236,-0.02185765,-0.049246233,-0.06771506,-0.039617416,0.038544845,0.0015024148,0.043402847,0.088227615,-0.0112590045,-0.020659968,-0.11487247,0.010046478,-0.03143431,-0.0682684,0.0024637727,-0.081096224,0.036315102,-0.03551248,-0.080544084,0.038650822,-0.016207334,-0.03126399,0.024937822,-0.03583538,0.0634683,-0.066002354,-0.044602077,-0.047846887,0.04398776,-0.098704904,-0.06992789,0.057801683,0.04135882,0.03966408,0.019593006,-0.055089466,0.027205056,0.026991405,0.015201427,-0.025844406,-0.028954528,-0.03192528,-0.038653575,0.033534996,0.059524756,-0.03820908,-0.015439707,-0.06074523,0.06823153,-0.012452413,-0.052404635,-0.024948524,-0.011094402,-0.08576907,0.006216675,0.1768443,-0.049568053 +3.4.21.121,"The enzyme is a serine peptidase, which has been shown to cleave prothrombin and prekallikrein. It hydrolyses the complement component C5 releasing complement component C5a.",384,1.0,-0.03717666,-0.024165796,-0.04510087,-0.011149873,0.025586635,0.10713632,-0.0066967746,0.10220142,0.030786054,0.0030157887,-0.03479156,-0.054632243,-0.099401355,0.048121747,-0.06269829,0.03991117,-0.008313294,-0.014330582,-0.014244538,-0.10986657,0.0319133,0.04200472,-0.023637462,0.030524997,-0.0062935413,-0.014972702,0.028491475,-0.04034512,0.04874965,-0.021214606,-0.08103014,-0.06735985,-0.016794214,-0.0048441016,-0.0064865793,0.08312846,-0.063638814,-0.039734725,0.037147604,0.048129406,0.046507947,0.004736823,-0.11455526,-0.016485063,-0.024228815,0.003482049,-0.02712819,0.06774504,0.056023292,0.0036681495,-0.04742814,-0.07075426,-0.03265526,0.014833588,-0.012243772,0.0013596922,-0.08751946,-0.09991957,0.055232204,0.012958598,-0.019099355,0.03571069,0.015824404,-0.010474852,0.09956208,-0.08717196,0.006955213,-0.01491503,0.032702662,-0.061378624,-0.036329817,-0.07958547,0.012573619,0.042941127,-0.0005800699,0.009829599,-0.030887822,-0.03448029,0.032656245,-0.013151066,-0.0034293323,0.060184997,-0.004300193,0.14127462,-0.00061850686,0.037097234,0.013987908,0.021148982,0.029275667,-0.03665303,0.024278,-0.018604286,-0.028521962,-0.01882351,-0.0792912,-0.0017880913,-0.014923975,-0.010959066,0.025674967,0.032095756,0.029233163,0.05445533,0.0042222664,-0.06619901,-0.073187366,-0.016952999,-0.00093247776,0.100477636,0.047506478,-0.05637992,-0.01226199,-0.034015,0.035018954,-0.04586552,-0.005119664,0.08691032,-0.0017211328,0.0017051741,0.04649362,0.03708486,0.0054301447,0.0454969,0.021795169,0.05272662,-0.036851533,0.053212244,-0.08245951,2.8232522e-33,0.08540818,-0.051276486,0.053905915,0.028242024,-0.04291283,0.00823863,-0.08011928,0.009131801,-0.027723191,-0.012654338,-0.067075364,-0.06296571,0.0075665205,0.0070909923,-0.027457476,-0.05337106,-0.051062543,-0.032253552,0.06504328,0.044854444,-0.016674126,0.078122996,-0.009066121,-0.0035925517,0.052921064,0.025437402,-0.04605629,0.033787873,0.064091116,0.011912292,-0.048366033,0.0099066775,-0.03714439,-0.06564475,-0.025006332,-0.054136623,0.0609463,-0.010189751,-0.040394966,0.050469495,0.03171667,-0.002442938,-0.048605274,-0.027234334,0.048417147,-0.13362092,-0.1349176,0.09494992,-0.004002144,0.023359299,0.094255775,-0.042351365,0.1088681,0.0032381862,-0.08984116,0.039670587,-0.029609302,0.057575256,0.075003095,0.063972704,0.03435014,0.05368285,-0.032337144,0.024684438,0.019854251,0.019069675,-0.03403065,-0.023889499,0.02911805,0.059481256,-0.13437352,0.041248802,0.05300259,0.09142186,0.03686251,-0.099085264,-0.052305102,0.05563597,-0.0015893901,0.04157661,0.017558206,0.015221091,0.026133513,0.08130715,-0.025013318,-0.059742276,-0.011919696,-0.10130526,-0.05972258,0.034102555,0.05362555,-0.058374465,-0.034222618,0.06267106,-0.041922327,-4.089813e-33,0.08271595,-0.16055425,0.0019360326,-0.031690136,-0.052894313,0.03799799,0.012627081,-0.021259852,-0.032374494,0.04531599,0.12353278,-0.0015374265,0.024262993,0.005442916,-0.0060009565,0.051727783,-0.025363723,0.058996603,-0.032684885,0.0292046,-0.043328203,0.04102816,0.07290505,-0.017176403,0.07910924,0.012265426,-0.00518849,0.06752053,-0.035370853,0.038556088,-0.034582183,-0.008005434,-0.08069145,-0.044372108,-0.08825587,0.00064832054,-0.033353586,0.019329745,0.050671298,-0.029887121,0.003253493,0.037686776,0.04518437,0.102420956,0.026409613,0.070220545,-0.0071389438,-0.035202395,0.008259275,-0.01260537,-0.0020994195,-0.045022916,-0.012520458,-0.016385367,0.02398877,0.013309977,0.006614968,-0.021023782,0.034608264,0.0569579,0.0027321794,-0.040709496,0.010084606,0.027595209,0.115932494,0.003796045,-0.045462683,0.03256637,0.069823235,-0.07858677,0.104918614,-0.02420118,0.044289574,0.015750205,0.0016135797,0.02566089,-0.028802665,0.0037952354,-0.0004431066,-0.027830541,-0.07031535,-0.041810676,-0.020943612,-0.05202127,0.04650744,-0.015238225,0.016238503,0.08634686,0.012358731,0.050960418,-0.062131505,-0.0142483255,-0.044801705,0.0034934308,0.04037703,-3.3333208e-08,0.10864204,-0.11069662,0.010724403,-0.036359485,-0.049045745,0.036852833,-0.038848612,-0.04484573,-0.022572294,-0.030941093,-0.004909349,0.043954443,-0.06450148,0.022730736,-0.0071391356,0.031061396,-0.01575634,0.07479685,-0.02006669,-0.08943766,-0.09179479,-0.018314999,0.021292737,0.013709625,0.0098829875,-0.14684013,0.015965354,0.12556867,-0.028848898,-0.037180517,-0.04895051,0.039303817,-0.0025786692,-0.06767536,0.035121646,0.099037066,-0.014982681,0.0026517347,0.008668588,0.027568506,0.042129308,-0.04594677,-0.06195108,-0.06452096,0.059285864,0.035983462,0.045537643,0.048148267,0.0038676243,-0.052225802,0.02092116,-0.015748987,-0.0033268505,0.017234555,-0.055341464,0.0011137608,-0.017986959,-0.09959428,0.009247813,-0.11971414,-0.036611088,0.06708645,0.15144023,-0.028702553 +3.5.1.114,"This enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). It preferentially deacetylates Nalpha-acetylated aromatic amino acids and mercapturic acids (S-conjugates of N-acetyl-L-cysteine) that are usually not deacetylated by EC 3.5.1.14, N-acyl-aliphatic-L-amino acid amidohydrolase. The enzyme is significantly activated by Co2+ and Ni2+ [3]. Some bacterial aminoacylases demonstrate substrate specificity for both EC 3.5.1.14 and EC 3.5.1.114. cf. EC 3.5.1.14, N-acyl-aliphatic-L-amino acid amidohydrolase and EC 3.5.1.15, aspartoacylase.",384,1.0,-0.015522232,-0.08587065,-0.064007975,-0.009553351,0.08569004,0.09594554,-0.06309743,0.023939827,0.07314664,-0.06255027,0.0040412904,-0.050788887,-0.026082762,0.04918476,-0.06834011,-0.01173829,-0.015415654,-0.08611782,0.0009201171,-0.117436215,0.009680579,0.042321257,-0.067702614,-0.030148594,0.03768604,-0.04458536,0.07041818,-0.05933588,-0.058748685,-0.07132755,0.004696527,-0.09783042,0.05191086,-0.030963767,0.07874754,0.03570684,-0.07511692,-0.059171077,0.07685108,0.029939147,0.018231412,0.009469386,0.010212335,-0.06763218,0.019532954,-0.0059140297,0.014194955,-0.001097419,0.05982027,-0.012636903,-0.065844886,-0.057066817,0.013513051,-0.0027573877,-0.02107297,0.007383074,-0.09922676,-0.06507651,-0.038567636,0.03244553,-0.017311994,0.005324578,0.054549795,-0.063678555,0.008347173,-0.010611587,0.05065654,-0.13941711,0.024846185,-0.008679199,-0.08003097,-0.07904265,0.036407076,0.028860532,0.01425547,-0.046132047,-0.017403094,-0.035683315,0.052570496,-0.056557912,0.02665932,0.023277791,-0.0090154335,0.059395473,0.040444672,-0.045999173,-0.00067429786,0.04408743,0.03389102,0.016413592,0.0054848124,-0.019382173,-0.0031769904,-0.0038277737,-0.020029929,0.009634314,0.030760875,0.07236396,-0.0027774626,-0.030913739,0.006041048,0.103329524,-0.004576432,-0.101715386,-0.05509056,0.035356164,0.042474106,0.13361542,0.059310313,0.006809376,-0.03696204,-0.028679634,0.0067413845,-0.022280578,0.015046,0.10661977,0.030665254,-0.05798634,-0.06515045,-0.013096619,0.051250663,-0.03841262,0.12703739,0.08697914,0.031372067,0.11001536,-0.07888799,3.4569125e-33,0.038200647,-0.006553438,-0.038585767,-0.015746722,0.016114766,-0.038107026,-0.10795112,0.04139287,0.037765022,-0.07248475,0.009879867,-0.04338604,0.030915836,-0.043081466,0.014233948,-0.0029565901,0.013476469,0.01978477,0.03214971,0.021633202,-0.00423353,0.044573475,-0.033462152,0.05550988,0.008882004,-0.029214885,-0.0034470023,0.023958094,0.06623463,-0.014079218,-0.0081429845,-0.10293342,-0.078971855,-0.018333616,0.058761872,-0.032891575,-0.04538894,-0.002076198,0.02042334,0.08776254,0.022193676,0.06970865,0.054543905,-0.04094097,0.016935432,-0.017525828,-0.06694061,0.09716101,0.014209941,0.00013755467,0.040550202,-0.016242623,0.15459417,-0.013321543,-0.036755517,0.032696,-0.06384634,0.017182734,0.047523517,0.0053518224,-0.03663253,-0.004401695,-0.029104546,0.013056004,-0.041871965,0.020040961,-0.037414055,-0.019019347,0.028272273,0.096218064,-0.06750855,-0.0019978085,0.04299742,0.08939091,0.02918338,-0.13307293,-0.085548006,0.06339227,0.045919336,0.026961224,-0.0008303409,0.05204175,0.056577314,0.03096902,0.0016806888,-0.021010976,0.016429212,-0.02334226,0.0068601114,0.002358359,0.024416398,-0.0596636,-0.04099159,0.026413444,0.031766452,-3.9846533e-33,0.11757322,-0.0964454,-0.0324201,-0.077904336,-0.08485741,0.08264784,0.044956587,-0.008195629,0.006892803,-0.070770904,0.08526017,0.02793905,0.048234377,-0.045733787,0.045016237,-0.03771444,-0.03015707,0.10683054,0.014499516,-0.020359576,-0.0073769977,-0.020735575,0.010490779,-0.029888952,0.09902752,0.055705994,-0.05488967,0.06629504,0.07325983,0.06689045,-0.0012904042,0.04672212,-0.027519463,-0.07809657,-0.042061172,0.05308669,-0.025619587,-0.0031425322,-0.06375564,0.0145187825,0.051642027,0.032486044,0.010690756,0.060830466,0.041118454,0.068768546,-0.025149152,0.0018490109,-0.068185985,-0.021223605,0.00933748,-0.021355847,-0.015233867,0.014023078,-0.0053742575,0.113380164,0.031244416,0.049992952,0.06339486,-0.027873348,-0.05770693,-0.04400933,0.014458933,0.002698486,-0.017842751,-0.012208088,-0.074014455,0.048398416,0.051189072,0.017043425,-0.03548684,0.0013854563,0.04768787,0.03735573,-0.03087522,0.01791452,-0.022922706,-0.011216982,-0.008960006,-0.057695214,-0.021107882,-0.019135583,-0.014182141,-0.032806527,-0.03645179,-0.037449524,0.055943105,0.08355333,-0.032773573,0.021578752,-0.024882095,-0.10392458,-0.11694533,0.03712864,0.0014953051,-5.174866e-08,0.035879064,-0.024286732,0.034630023,-0.0554329,0.047405157,0.07858562,-0.020029357,-0.029481674,0.03139708,-0.07840853,-0.013446566,0.03458598,-0.023947557,0.026754888,-0.06609198,0.009714549,0.0038794824,0.034256198,0.004263644,0.077776656,-0.07850952,-0.0046128165,-0.11255944,-0.0009882963,-0.005569253,-0.02384648,0.027102016,0.056605995,-0.079896525,-0.07001027,-0.06905214,0.03039395,0.0938217,-0.061919544,0.02368899,-0.018283753,-0.03774124,-0.041044895,-0.01736486,0.036235183,0.047498744,0.019140862,-0.06344074,0.0022661695,0.08539464,-0.012702988,0.033656117,0.01306075,-0.02470879,0.026773497,0.0116810845,-0.088138565,0.011660533,-0.05831535,-0.031964626,-0.0033671688,-0.007984833,-0.14397565,0.013531406,-0.008159673,0.021004587,0.02569697,0.16866207,-0.0008449994 +3.5.1.115,"The enzyme that is found in actinomycetes is involved in the detoxification of oxidizing agents and electrophilic antibiotics. The enzyme has low activity with 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol as substrate (cf. EC 3.5.1.103, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase) [2].",384,0.9999999,-0.036740813,-0.08634851,-0.037311263,0.016231224,0.049856756,-0.035940845,0.069001585,0.090713374,0.0026151368,0.06851822,0.023266133,0.015477481,0.023163654,0.085816234,-0.08973268,0.10101636,0.0025510064,-0.035330053,0.040127147,0.039747175,0.07666873,0.053738028,-0.030147832,0.004130451,0.10051953,-0.026783893,0.004340957,0.027099252,-0.08183522,-0.13182095,0.04419049,-0.011870029,0.13406171,-0.017173618,0.06694526,0.11394914,-0.059088122,-0.07070466,0.1301492,-0.034458183,-0.017002856,0.038531918,0.0026946277,0.0519473,-0.043236893,0.013288838,-0.04874724,0.044617437,0.070531994,0.038405,-0.05697862,-0.06390463,-0.0109001985,0.022816667,0.022685474,0.016122174,-0.028995343,-0.026646042,-0.0566182,0.043347947,0.058368366,0.016378302,0.03696038,0.005832211,-0.04384406,-0.0066130343,0.07590382,-0.044379175,-0.011180669,-0.0477927,-0.059156638,-0.07256463,0.0029781181,0.03184034,0.00022061056,-0.024669807,0.029867742,-0.06529075,-0.039385132,-0.019545417,0.013739026,-0.02582901,0.04134519,0.044621717,0.042142525,-0.02423504,0.051260922,-0.005995111,0.04880501,0.027189113,0.016466048,-0.008661134,-0.034642488,-0.053061225,0.011062514,-0.045637056,0.0126901725,0.075209305,-0.031066444,0.009589174,-0.0108174225,0.043441936,-0.024167206,-0.08724739,0.0060489993,0.02317927,0.02616368,-0.0058237566,0.05181639,-0.0038906191,-0.019908333,-0.007406125,0.023198158,0.038153503,-0.054942805,0.11026947,0.10392092,-0.03156202,-0.0828133,-0.0022389358,0.024739748,0.027391365,0.04434369,-0.003882216,-0.09985082,0.065805964,-0.024725592,1.9557605e-33,-0.038253173,-0.024845816,9.947177e-05,0.024946807,0.030145839,-0.016148442,-0.054467376,-0.04277064,0.08107488,-0.054726735,-0.14626051,-0.0889649,0.027092338,0.07454141,-0.07699962,0.0049538817,0.0037035043,-0.040735707,0.07920028,0.063134484,0.0052219555,-0.019640816,-0.07157226,-0.026228396,0.009929991,0.0785884,-0.017153386,0.056060564,0.07860892,-0.030641682,0.022000428,-0.011444488,-0.1440696,0.016685493,-0.00025404085,-0.020258028,-0.0498428,-0.026662018,0.036882088,0.018938754,-0.06143215,0.037212834,-0.017498469,-0.010634073,0.05814586,-0.044388387,-0.080134965,0.048833214,0.061573487,0.05046103,0.03787259,-0.06913741,0.094048195,-0.04301796,-0.024879225,-0.0014560688,-0.033621103,0.016397137,0.08865895,0.04434909,0.037028987,0.038615834,0.0028323221,0.02226075,-0.01556626,0.0068856548,-0.066342264,0.009653295,-0.037159827,0.049973544,-0.033901725,-0.014425942,0.025353493,0.0065119187,-0.011747698,-0.049771722,-0.06331188,-0.052068703,-0.017050963,-0.0044900696,0.017499933,-0.07302765,-0.023600407,-0.022597803,-0.0047831805,0.02403445,0.007210197,-0.05880813,-0.029497826,0.027138835,-0.0051635336,-0.062696785,-0.18019159,0.011775447,0.03079334,-3.7615074e-33,0.116827086,-0.081935585,0.077364355,-0.072276376,-0.05268023,0.08945282,0.046249703,0.06012239,0.03571043,0.03948347,0.016113374,-0.0095992405,-0.061690085,-0.09521657,0.046163358,-0.009606302,-0.041838665,0.028065892,-0.014973882,0.008534975,-0.020287367,0.14317247,-0.0074838125,-0.003378232,0.02886897,-0.02174188,-0.07899559,0.04989372,0.04548521,0.022446806,0.011858148,-0.006182621,-0.01915529,-0.059759595,-0.009741409,0.055206224,-0.11497138,-0.010932504,0.002055714,-0.04200074,-0.010772619,0.05088726,-0.012153591,0.09196967,-0.00291931,0.089443125,-0.14578202,-0.02856873,-0.02112412,-0.07003274,-0.012259592,-0.000739477,0.010390856,-0.012895366,0.07205681,0.021884939,2.1313335e-05,-0.011848546,-0.053493004,0.018460633,-0.00046877167,0.018025558,-0.01380113,-0.044234205,0.045034725,0.07969315,-0.06590447,0.09066152,0.012814824,0.044099625,0.02521909,-0.025075162,-0.05175688,0.021007031,-0.025175443,-0.023719838,-0.09767272,0.015447988,0.027262488,-0.06373171,0.051869206,-0.0027271248,-0.014357739,0.011273634,-0.06219265,-0.08703742,0.0013483214,0.09807234,-0.02170356,0.06456473,0.008789947,0.017624324,-0.04528802,0.019366879,0.026012674,-4.862675e-08,0.11813573,-0.036359552,0.12462671,-0.0650457,-0.009958735,-0.008696837,-0.039825123,0.031729557,0.046841417,-0.007955449,-0.006946254,0.06462459,0.010946762,-0.010238411,-0.008810338,0.013893653,-0.034616355,0.049902126,0.01097353,0.07457315,-0.065744296,-0.018819751,-0.10598909,0.010349763,0.05946581,-0.04549697,0.044671502,0.042973757,-0.04824989,-0.005780306,0.015067756,0.0055924547,-0.017012263,-0.015648194,-0.101380445,0.021396648,-0.09128623,-0.055149827,-0.013392144,-0.010857425,-0.026593115,-0.03608388,-0.006874522,-0.020034652,-0.042443655,0.007811532,-0.009749943,-0.035337597,0.03717222,0.040356476,0.022450166,0.036602505,-0.05790731,-0.0014050768,-0.11076164,0.063081,-0.0037268251,0.0015222583,-0.0072432607,-0.07313463,0.00018088742,-0.036228336,0.11180261,-0.02469624 +3.5.3.26,"Binds Mn2+. This enzyme, found in plants and bacteria, is part of the ureide pathway, which enables the recycling of the nitrogen in purine compounds. In plants it is localized in the endoplasmic reticulum.",384,1.0,-0.042053323,-0.036026258,-0.040200002,0.0045627807,0.054298863,0.07791684,0.015531678,0.0003548506,0.04886476,0.03447575,0.078243785,0.00095075206,0.015083505,-0.011860482,-0.07855977,0.05272795,-0.13852058,0.011346636,0.004150745,-0.010059186,0.10048599,0.08415399,-0.07875801,-0.12892537,0.055950798,0.051990606,0.014518826,-0.068183586,0.029133335,-0.082842186,-0.051098432,0.02885208,0.025984645,-0.05218998,0.010771196,0.13789329,0.044134524,-0.06798677,-0.004289316,0.012883036,0.030215662,-0.011777545,0.06675084,-0.029107586,-0.018054068,0.022004453,0.07604122,-0.008342444,-0.0028764529,0.006681612,-0.0055023995,-0.06629387,0.01689522,0.0645728,0.02344254,0.0286693,-0.04861538,0.02507733,-0.044161458,-0.005883662,0.062467244,-0.018094452,0.008438663,-0.018693984,0.08152033,-0.0397841,-0.03809705,-0.038465988,0.020642722,-0.052138366,0.023912387,-0.029591957,-0.018298896,0.0073088543,0.008296,0.04692166,-0.027504753,-0.0036162313,0.033128425,-0.02457718,0.03297216,0.053066485,0.08747575,0.042791422,0.046029657,0.05796025,0.009224531,0.03222908,-0.005867383,0.00045076292,-0.0029525913,-0.032745797,-0.004032293,0.023376575,-0.020002726,0.021916002,0.020304149,0.0031158556,-0.00463845,-0.03826935,0.015641956,0.073433384,-0.07928264,-0.09036174,0.023315402,0.007303271,0.0053922804,0.021547819,-0.002557986,0.026340801,0.011303427,0.048859686,0.010589534,0.041349962,0.034205053,0.04074659,0.062849924,-0.045944486,-0.0749821,-0.053739946,-0.036558606,0.021352619,-0.10647495,0.049477004,-0.033485755,0.026300298,-0.11919135,-1.52525985e-33,0.0713159,0.0014484774,-0.03243292,0.0035867156,0.029317752,0.02026845,-0.0036199538,-0.0710668,0.036099646,-0.068408,-0.109605566,-0.102824606,0.022651074,0.042157177,-0.0442713,-0.080671534,-0.0032677557,0.007933709,0.11817989,-0.028115725,-0.0020974076,0.06870685,-0.06625386,-0.036378924,0.007858167,0.04111806,0.09843262,-0.014260787,0.104956485,-0.048612304,0.05677659,-0.08398759,-0.06943808,0.03240566,0.09462379,-0.035338577,-0.026435502,0.029494653,-0.08822105,0.016125977,-0.0061377315,0.04901079,-0.093166254,0.024788113,0.062307857,-0.10779286,-0.06555029,0.022336828,-0.0069710845,0.0010425278,-0.021239799,0.028272964,0.06710394,-0.010076803,-0.055379964,-0.012680886,-0.007017272,0.0068099755,-0.05994939,0.059481278,-0.018232554,0.042320333,0.03156027,0.09440275,0.05485253,0.06977313,-0.05702719,-0.09803064,0.045816664,0.12644845,-0.019628415,-0.12090863,0.07543914,-0.026310718,-0.021967655,-0.053222463,-0.10986831,-0.012789779,-0.00703399,0.018956596,0.021337379,-0.0811797,-0.005168014,0.0013541437,-0.07626761,-0.055190932,-0.025366887,-0.097648695,0.0050755125,-0.013905151,0.09660888,0.04846893,-0.04598949,0.00085623196,0.010826786,1.1253666e-34,0.09740662,-0.046721186,0.119209245,-0.033728663,-0.12414184,0.04536285,-0.0785443,-0.083568424,0.031014036,0.02619402,0.066150405,0.033795577,0.041838728,0.021667685,0.034025457,-0.017730495,0.037326995,0.07401834,0.0387574,-0.015235233,-0.035393007,0.032175865,0.0058199433,0.057698425,0.0038886622,0.017818429,0.002319397,0.005688417,-0.02432844,-0.05251407,0.010051529,-0.0610396,-0.10089825,-0.088615306,-0.011079056,-0.023569686,-0.060329974,-0.051587325,0.007059969,-0.037059143,0.047518384,-0.034695763,0.022665026,0.08773031,-0.002452571,-0.078154236,-0.08930613,0.05125991,-0.028876808,-0.039779946,-0.011683292,-0.025945788,-0.0156183215,-0.049605474,0.037891075,0.019154003,-0.021856487,0.047359284,0.065613836,0.0037867893,0.0091501055,-0.030016163,-0.007857676,0.049477816,-0.007548615,0.03556682,0.038000025,0.033712745,0.01699006,0.03527712,0.048798088,0.062469628,0.092109665,0.052340835,-0.04698743,-0.07798014,-0.007968851,-0.043988235,0.016869023,-0.08801583,-0.027260495,-0.0056227306,-0.04178344,-0.07473048,0.024834335,-0.012608373,0.032125957,0.11580368,0.00087008113,0.012974076,0.0046888706,-0.050899617,-0.096684664,-0.008345806,0.030079678,-2.9259112e-08,0.010423949,-0.08329701,-0.017419647,-0.07046063,-0.08245571,0.011282951,0.024656693,0.06978003,0.07695772,0.019363567,0.031013966,0.048925515,-0.0022228064,-0.011697462,0.064678445,0.034391224,0.055584464,-0.0010894296,-0.019832207,-0.0015280492,-0.011085657,-0.02595787,-0.08060275,0.08992693,0.05055787,-0.02898877,0.03570275,0.09308885,-0.0033049795,-0.022732027,0.07497711,0.0073625627,0.028456219,-0.05177287,-0.035959013,0.08944492,0.025126684,-0.019655317,-0.009915088,0.0063835043,-0.05157507,0.023307092,0.027796349,-0.011507422,-0.06971644,-0.01717517,0.015899489,0.062116794,-0.0069238427,0.010112516,-0.018132271,-0.052946422,0.04171869,-0.12082529,-0.07640973,0.034636993,-0.000173666,-0.021171559,0.02343327,0.059156407,-0.043315798,0.03498526,0.06977311,-0.04708337 +3.6.1.66,"The enzymes from the bacterium Escherichia coli and the archaea Methanococcus jannaschii and Archaeoglobus fulgidus are highly specific for XTP, dITP and ITP. The activity is dependent on divalent cations, Mg2+ is preferred.",384,0.99999994,-0.06985351,-0.07092416,0.029893713,-0.018376289,0.074750826,-0.06363492,0.0074855355,0.076636836,0.022983735,-0.012397004,0.021486582,-0.012514654,-0.037316397,0.08635155,-0.0078372825,-0.008804749,0.037485234,0.0075704823,0.03929623,0.058804113,0.092381865,0.022414505,-0.082516,-0.05488781,-0.0064760917,0.030746179,0.02384313,-0.07986904,-0.024035875,-0.031999882,-0.02205363,-0.007933236,0.08796001,-0.054209642,0.058127362,0.10781608,0.0011209709,-0.11376716,0.038838327,-0.069065966,0.017668098,0.016055718,0.08746175,-0.035366423,0.0040350975,-0.051731575,0.011722603,-0.0010368965,-0.0030289027,-0.03728422,-0.025172021,0.018576816,-0.02177913,0.019311914,0.09278752,0.008521691,-0.085055225,-0.06516012,-0.08170262,0.0017663122,0.01016205,0.117678694,0.030623546,-0.03152617,0.029750308,-0.051267613,0.009687239,-0.0072040847,0.08665355,-0.051738575,-0.08492186,0.038669992,-0.050873205,-0.02881944,-0.025541855,0.045116186,0.06470884,-0.04929651,0.018580107,-0.058115084,0.023836978,0.06182229,0.058927212,0.04802468,0.028843008,-0.028232912,0.017359732,0.073314466,-0.017013043,0.07429185,0.08313782,0.061758928,-0.012974008,-0.021513704,-0.0043743234,-0.027463464,-0.012594647,-0.019018896,-0.013067945,-0.0021955112,-0.013119391,0.06991283,-0.03234187,-0.064457186,-0.085968144,-0.09130418,0.012418135,0.06051399,-0.0070536635,-0.025546465,0.054756794,-0.056133978,0.032955125,0.022417827,0.0068815267,0.018551603,-0.008240576,-0.092196,-0.057309363,-0.01793138,-0.04038613,-0.10425072,0.016159624,0.07820963,-0.07857226,0.007399988,-0.064826325,5.4589337e-33,-0.035362575,0.03992104,-0.035656255,-0.06362833,0.010624008,-0.013298166,0.01802294,0.019496601,-0.05326386,0.0013893233,-0.1076097,-0.017441222,0.0039109117,-0.013909055,-0.075345695,-0.051421087,-0.022332625,0.076717794,0.06745937,0.019826107,0.040273298,0.05869063,0.012171797,-0.039105866,0.085439794,0.07309024,-0.05068574,-0.057338562,0.028926525,0.010883096,0.04924276,-0.12262714,-0.070439,0.106365964,0.03716617,0.080643214,-0.068590336,-0.07663403,-0.051758062,0.0026382967,-0.049358007,0.055165987,-0.04533306,-0.00087053614,0.043554496,0.023172189,-0.058883026,-0.0077174488,-0.022000013,-0.035657678,0.030237569,0.020339638,-0.008796459,-0.019209547,-0.018445693,-0.010346829,-0.04930839,0.044744983,0.073202536,0.08956769,0.0050793784,0.04795616,-0.096304506,0.010639148,0.05130475,0.057725646,-0.014207004,-0.09824502,0.061651267,0.14814304,-0.06777678,-0.07384574,0.1104596,0.014484327,0.03208016,-0.047420107,-0.06025817,0.035048556,0.0045720595,0.057775114,0.015992116,-0.06123684,0.028467832,-0.011531502,-0.048276488,0.047664497,-0.0011432323,0.0737411,-0.0032070575,0.07802107,0.093682066,-0.04279441,-0.0059159845,0.03510461,0.02010666,-5.2615814e-33,0.017299505,-0.06600526,-0.017948229,-0.024374478,-0.09441681,0.06442794,-0.003233848,-0.07914049,0.07249397,-0.0029430958,0.10971336,0.0019179514,0.04135447,-0.07326127,-0.018051192,-0.011059171,0.048420493,0.019064883,-0.032065604,0.002212278,-0.010707282,0.07280915,0.0097896885,-0.0072850827,0.04796098,0.0285488,0.019080108,0.017970923,0.021390673,-0.008785197,-0.004308061,0.100051016,-0.034367803,-0.06777214,-0.056031063,-0.044036895,-0.090921886,0.04884608,0.016765498,0.053731944,0.051316526,0.07374895,0.05461567,0.094640344,-0.020169575,0.0612381,-0.10509218,0.022876423,0.10084374,-0.011311604,0.018893708,-0.04237315,-0.018045628,-0.061934277,0.009236946,0.07173131,0.02150503,0.036460787,-0.0016472329,0.037547976,-0.04991151,-0.10192331,0.081511535,-0.0033829415,0.023867603,0.025308283,0.011691924,0.020883586,0.001611724,-0.030970354,0.047412705,-0.009350139,0.003388968,0.0025813517,-0.06448971,0.026740817,-0.078734905,-0.010943015,0.084593356,-0.01696091,0.009473552,0.049559288,0.024288552,-0.06305144,0.044554554,-0.049975794,0.039268017,0.112344034,-0.0006087031,-0.0062901904,-0.051473856,-0.03323229,-0.033018705,-0.06103497,0.03658929,-3.8004494e-08,-0.046683263,-0.08476279,0.009730397,0.00025935093,-0.060087707,0.08069235,0.013833918,0.019210145,0.079646714,0.047305893,0.05000938,0.031960912,-0.060968727,-0.044708785,0.026276942,-0.00032284198,-0.0068096365,-0.014250265,-0.051391155,-0.049069207,0.00071106036,-0.016318271,-0.070843674,-0.008289302,-0.0011820431,-0.08573005,0.030319575,-0.0066612177,0.016009212,-0.08307147,-0.07053351,0.0025697942,-0.010873323,0.018588953,-0.058232654,0.060012188,-0.03639186,-0.08801463,-0.046883408,0.008963423,0.0121952575,-0.0639063,-0.019508066,-0.032120604,-0.03234859,0.0662393,0.050488878,-0.00508441,-0.07572591,-0.011512952,0.07025621,-0.045861974,0.025167186,-0.06031488,-0.030704908,0.06961405,0.029468141,-0.06804642,-0.046510722,-0.049956996,0.013166916,-0.010158979,0.12124331,-0.018513225 +4.1.3.45,"The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3].",384,1.0,-0.0075909547,-0.043645114,-0.058466837,-0.022181755,0.107003614,0.075462736,-0.045445092,0.031365514,0.021130685,-0.0070621516,0.07782788,-0.11287902,-0.02503922,0.014552552,0.0074971574,0.031657908,-0.07386905,0.013807184,-0.018975375,-0.057457104,0.0663924,-0.0060930233,-0.01006681,-0.0031109746,0.017518315,-0.022705903,0.06435698,-0.084557116,-0.035929494,-0.100890614,-0.036559455,-0.048012957,0.13687211,-0.082917765,0.05003455,0.072212115,-0.013780697,-0.10737797,0.103116006,0.020441217,0.024601873,-0.040242147,0.03166726,-0.08915985,-0.06235467,0.0015323214,0.054617785,-0.00016819763,0.008045957,-0.016188467,-0.035507474,-0.034024518,0.003850281,-0.0021864737,0.035736155,0.002077836,-0.023592276,-0.045498412,-0.03319548,-0.018656457,0.09719188,0.08656643,0.010957763,-0.016167557,-0.09009616,-0.09443945,0.03952521,-0.04284577,-0.008688189,-0.033523705,-0.034880586,-0.09854425,-0.020700255,0.0417207,0.01983161,0.034344174,0.044651397,-0.07587405,0.02590626,-0.049043633,-0.014905391,-0.011196187,0.006444311,0.04536093,0.012524174,-0.047907956,0.02897993,0.022848949,0.0400025,0.06822088,0.056684535,-0.029644066,-0.038816888,-0.047562663,-0.019260032,0.021195568,0.08000404,0.025102569,0.057125952,-0.051223908,0.011280635,0.028899882,-0.026734529,-0.06676898,-0.032826908,-0.04579921,0.022941947,0.06957739,0.0056209625,-0.028498732,-0.009895413,-0.035557408,0.0158664,-0.012963363,-0.06311924,0.12515037,0.06861399,-0.048703335,-0.08791619,0.05773805,0.06484399,-0.036307503,0.07498378,0.116732396,-0.024080131,-0.0006086899,-0.10011883,1.5265655e-33,0.032946438,0.034502685,-0.04042926,-0.07466579,0.022969669,-0.010329545,-0.060140625,0.014659229,-0.050481178,-0.05547051,-0.08644414,-0.07279905,0.029080598,0.021913543,-0.031104663,-0.0051159575,0.010551878,-0.014860976,0.045304798,0.025264705,-0.010154965,0.041836627,-0.03611657,0.024435926,0.04732705,0.023461672,0.08397898,-0.03334284,0.033575866,0.0050135353,0.015273984,-0.104416385,-0.041222997,0.06027214,0.043487225,0.037550945,-0.009208121,-0.053439446,-0.04918295,0.043728195,0.058295727,0.08285404,0.05211699,-0.045998324,0.025941882,-0.05288253,-0.050910164,0.043183364,0.11292504,0.05647208,0.027089696,-0.009391357,0.101804584,0.009361658,-0.017643623,0.04597472,-0.09866005,0.031466134,0.014171627,0.06025195,-0.045324426,0.047244884,-0.042530995,0.02784445,0.007630546,0.041877232,-0.02273184,-0.08414592,-0.03591537,0.03958833,-0.10758597,-0.12509786,0.085256204,0.009571073,0.065294065,-0.049212195,-0.084603265,0.010313617,0.008810852,-0.013860534,-0.02402249,0.010979334,0.048735887,0.0001554662,-0.08117894,-0.043143038,-0.055366732,0.018647028,0.0072983634,0.08950459,0.026233746,-0.0588292,-0.058066204,0.070434496,-2.7963493e-05,-2.3461888e-33,0.00046599048,-0.054176264,0.07926937,-0.05529439,-0.06655261,0.099401094,-0.022397537,-0.049835827,-0.029855879,0.0037559695,0.057614513,-0.0096099805,0.026800014,-0.061979327,0.012217281,0.070914574,0.061541453,0.08300693,-0.0027594317,-0.006756032,-0.007951835,0.038963687,0.006905635,-0.056470573,0.10343127,0.00918158,0.02377585,0.09682306,0.048358858,-0.033059806,-0.033827186,-0.0013757913,-0.035215903,-0.02652443,-0.03386147,0.0069926395,-0.039350882,0.020158214,0.011833917,0.05267553,0.04294132,0.03073581,0.055585504,0.08117526,0.020143468,0.060241114,-0.017768567,0.017037017,0.05083126,-0.055630673,-0.0056049046,-0.05058183,-0.009153234,-0.017818222,0.032049034,0.04304429,-0.018134452,0.09119031,0.0054586804,-0.04476269,0.0037612622,-0.050361842,0.07874073,-0.017318731,0.037468333,0.0066856514,-0.05870231,0.02442615,0.0055421484,-0.018379167,0.08264102,0.0056635537,-0.043160897,0.025672892,-0.061851755,0.010204715,-0.09630881,-0.113921806,0.008795053,-0.04933129,0.05950788,-0.01224369,0.024313552,-0.07815925,-0.01064884,-0.02970904,0.07615537,0.13536733,0.014806291,0.015024433,-0.02536504,-0.03140315,-0.047016054,0.074072,0.09389662,-3.4303294e-08,-0.020325847,-0.09590494,-0.00022814484,-0.02365837,-0.01598588,0.024630586,0.020927764,-0.007462096,0.039881147,-0.026980288,-0.049235206,0.042265777,0.041244034,0.0019897216,0.04202781,-0.000103674196,0.00849479,0.029314376,-0.03167612,0.047524232,-0.061373264,-0.00064149295,-0.11556582,-0.0031771709,-0.0373719,-0.038450554,0.07193025,0.050693143,0.01715116,-0.059457373,-0.034945477,0.028884716,-0.028702319,-0.024709094,-0.080172874,0.020736909,-0.08829007,-0.07807463,0.0069981753,0.03327971,0.033758502,-0.04643144,-0.06887476,0.024401592,-0.002397492,0.029311134,-1.4686547e-05,0.008084223,-0.01888118,-0.031838167,0.0431239,-0.07678783,0.019909898,-0.065375306,-0.038782228,0.03655768,0.022734703,-0.04473533,0.0033307676,-0.029115537,-0.022188984,0.024370559,0.19125257,-0.01621477 +5.1.3.27,"The enzyme is involved in the biosynthetic pathway of dTDP-6-deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II. 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+4.3.1.29,"The enzyme, from the bacterium Salmonella typhimurium, is involved in the degradation pathway of 2-amino-2-deoxy-D-gluconate.",384,1.0,-0.039359625,-0.033367507,0.00447804,-0.028224794,0.022736471,-0.020466475,0.008954293,0.09676692,0.044352263,-0.00010591473,-0.0064286715,0.013979802,-0.044162583,0.05608813,-0.035813574,0.009865023,-0.05570867,0.009253119,-0.04212634,-0.055378657,0.056732275,0.046980057,-0.009977025,-0.03803258,0.040683102,0.079291046,0.052112564,0.007386476,-0.016724434,-0.055624686,-0.008824357,-0.039303694,0.0666367,-0.040431634,0.069801904,0.09220236,0.011064082,-0.029458921,0.079870746,-0.0044014505,-0.00030430968,0.090692185,-0.026863553,-0.017572429,-0.052610826,0.023515876,0.013103131,0.047947258,0.039649982,0.0006955508,-0.035942353,-0.04040183,-0.00799493,-0.008940927,0.046493497,0.052458607,-0.018994797,-0.074224696,-0.0956148,-0.017621571,0.055538863,0.014510374,0.035278447,0.005851142,0.013429928,-0.061115503,0.071141824,-0.04352559,-0.023281159,-0.07760582,-0.023193007,-0.064443395,-0.028641568,0.010816278,-0.036164884,-0.02389125,0.002237526,-0.115754515,0.061026294,-0.03733097,0.050809935,-0.026977148,0.10336939,0.074628145,0.004165354,-0.03157616,0.00035561918,-0.025487902,0.075051494,-0.006454885,0.0019898193,-0.04833302,0.04032447,-0.029676644,-0.016060814,0.017319385,-0.0013248634,0.031709433,0.04068934,0.0013648311,-0.06197577,0.041573115,-0.04515082,-0.106034815,0.018083237,-0.023858536,0.040526953,0.13461275,0.058900945,-0.040844414,0.021497238,0.013795559,0.09789855,0.050636444,-0.03150747,0.07122195,0.08926844,0.021433398,-0.07288218,9.152299e-05,0.008530132,-0.048133064,0.027953077,0.0027983636,-0.068483,0.07050683,0.00800021,-1.6257809e-33,0.06945403,-0.022218933,0.012514457,0.023772376,0.045852125,-0.03461751,-0.047397744,-0.05441833,-0.01014988,0.009849489,-0.11202059,-0.09669571,-0.014980979,0.03167864,-0.0053863665,0.043867685,-0.027020482,0.0065359427,0.037704855,0.047964633,0.081866294,0.055729885,0.008662993,-0.010965003,0.046205726,0.055105045,0.019621875,0.07623795,0.010870503,-0.02064651,-0.02391632,-0.063398875,-0.15190183,-0.003929354,0.080983706,-0.014439191,-0.058955025,0.034166228,-0.008313705,0.018498013,-0.036782537,0.015733307,-0.027888583,-0.033670355,0.07023187,-0.03634312,-0.0015454313,0.08952849,-0.003124343,0.05662521,0.02493628,-0.0144030275,0.059654307,-0.011016353,-0.03528535,-0.0065797293,0.07018735,0.008555369,0.09774531,0.07275649,-0.0007681188,0.06953425,-0.061900016,0.06868752,0.095083706,0.004146912,-0.008988258,-0.008225187,-0.031661276,0.094699174,-0.033134237,-0.040563017,0.0042957505,0.0018695998,-0.03772598,-0.11053277,-0.08258112,-0.055361994,0.09641218,-0.066907175,-0.017233394,-0.022814168,-0.011186603,-0.02944091,-0.07963027,0.030632572,-0.008185224,-0.047972616,-0.014079255,0.05896493,0.020131996,-0.01895703,-0.09002346,-0.029287823,-0.0056136874,1.752202e-34,0.031170027,-0.06322355,-0.0395056,-0.077680595,-0.08465848,0.030036373,0.011306383,0.04957276,0.06533136,0.0005813957,0.08193329,0.027275631,-0.041158207,0.00237439,-0.028278155,-0.009755462,0.016386962,0.029116338,-0.07719227,-0.07973628,0.027704641,0.05369187,-0.018550305,-0.029045865,0.013825654,0.006538473,-0.003142737,0.108157896,0.04358831,0.026786169,-0.015339085,0.048782606,0.021362811,-0.010313925,-0.02170298,0.06137641,-0.01955266,0.015033523,0.012247858,-0.04982596,-0.0032890623,0.04228062,0.021792592,0.08034964,0.027704187,0.095970236,-0.12888023,-0.026559092,0.0066240267,-0.032301404,-1.1609226e-05,-0.05764795,0.014041639,-0.0041488903,-0.0040382766,0.0042323815,-0.015787777,-0.022833575,-0.050998416,0.028015457,0.008096385,-0.068386875,0.0826903,0.0150379995,0.01754634,0.004417947,-0.03516169,0.08646542,-0.0016462001,0.03875874,0.0045392797,0.030442098,0.0122714145,0.0007359977,-0.0874133,-0.06670488,-0.10095471,0.016202768,0.10061552,-0.07638535,0.050370395,-0.015570347,-0.061820813,-0.022238499,0.018564446,-0.089565046,0.014091129,0.14092605,-0.0036905517,0.06788807,-0.05610744,-0.054625493,-0.059297364,0.044288334,0.05776194,-2.8656835e-08,0.027208097,-0.03941073,0.04572047,-0.019854011,0.0015140385,0.030239688,-0.017986562,0.052682973,0.1340358,-0.063074805,-0.035309277,0.1762353,-0.045473028,-0.021530662,-0.053442676,0.09951301,-0.06666008,-0.05680954,-0.011877622,-0.059892096,-0.0068694986,-0.04777026,-0.08222392,0.016947351,0.035549108,-0.05509952,0.037349526,0.038787503,0.0007573866,-0.04955301,-0.044962205,0.018259527,0.0066169547,-0.022244439,-0.05025835,-0.03067133,-0.116176926,-0.037633084,0.015770365,0.017022103,-0.0070420783,0.039565515,-0.09117468,-0.020634217,-0.0029481219,0.02804656,-0.037814412,0.022351798,-0.052889314,-0.007633895,0.064687766,-0.03860487,-0.00088737905,0.010662767,-0.17673299,0.04330925,-0.0047238707,-0.015924294,-0.04667274,-0.04873456,-0.0067169503,-0.005985412,0.14989266,-0.034986597 +5.5.1.24,The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols).,384,1.0,-0.09696298,-0.0033975993,-0.07295094,-0.017651336,0.069661975,0.11086311,-0.061353605,0.050980285,0.033602953,0.010219185,0.015330773,-0.068198346,-0.03257224,0.04137555,-0.11246876,0.08965307,-0.031473532,0.013667854,-0.013301936,-0.034684747,-0.025848383,0.010919564,0.0029252802,0.073834464,0.06227441,-0.05722651,-0.008234205,0.019889556,-0.07900403,0.0154144475,0.025907071,-0.03872498,0.049182028,-0.05236125,-0.022580096,0.06861155,-0.0106601,-0.06764307,0.06463397,0.010099161,0.01231547,-0.054277636,-0.0757196,-0.00096388586,0.04236367,0.029902887,0.043226577,0.04556211,0.055244885,-0.010479848,0.0089575015,0.02047818,-0.060238104,-0.033070337,-0.030211816,0.031251084,-0.04389611,0.026290754,-0.057000402,0.06943996,0.06790607,-0.02098789,-0.032120705,0.07878372,-0.02348451,0.023213284,-0.0024614874,-0.048550997,0.0055172564,-0.09936053,-0.06337975,-0.14242283,-0.0221727,0.011547495,-0.014594233,0.058009654,1.6707774e-05,0.012821825,0.044337764,-0.07213069,0.04081832,0.011260051,-0.0409639,0.072041936,0.009451896,-0.0064844275,-0.017443804,0.008770054,0.12632678,0.07865594,0.040430788,-0.0043912632,-0.04089351,-0.026826752,-0.08231582,0.04233639,0.0770901,0.005554879,0.07541129,-0.031656634,0.021409897,0.022265662,-0.02008228,-0.103504084,-0.073996775,0.027080342,0.0011100777,0.029452069,0.03098511,-0.012356472,-0.0221752,0.010300894,-0.036104918,-0.03245821,-0.011411755,0.030483114,0.04968254,-0.05941065,-0.087551996,0.08340347,0.017567597,-0.017300382,0.07827981,0.029526744,-0.021044195,0.041334856,-0.037675645,6.087021e-34,0.05256303,0.04129113,0.02582004,0.017842691,0.014954895,0.030214885,-0.06822515,0.060236644,-0.07277785,-0.10445496,-0.06715549,-0.008170931,0.02892516,0.009202124,-0.039824545,0.027585309,0.027243666,-0.027790261,0.03441287,0.00350612,-0.029870443,0.026858957,-0.035409685,-0.006157351,0.031241488,0.054781895,-0.08367627,0.03113791,-0.00013339524,-0.004960113,-0.022412408,-0.12042448,-0.09956496,-0.015314573,0.056453153,-0.0030362634,-0.045705065,-0.011728798,0.010989736,0.06488191,0.050343692,0.02851903,0.015889242,-0.008963873,-0.01736814,0.019178465,-0.062299654,0.03975227,0.08766625,0.010675425,0.056533184,-0.018675243,0.07109147,-0.050101984,-0.03127639,0.04937283,0.001746096,0.06239662,0.01982222,0.0011074567,-0.05753753,0.102325,-0.0129470555,0.019547429,0.029251248,-0.051167127,-0.08679783,0.026339686,-0.064682566,0.03685629,-0.0016061448,0.014330024,0.06714726,-0.010622198,0.037452247,-0.031700082,-0.08411686,-0.03300141,0.025666203,-0.026656952,-0.034178387,-0.058437753,0.04695158,-0.007052341,-0.069304846,0.0056991484,-0.022373946,0.002296517,0.017884582,0.006775858,0.055016886,-0.03511961,-0.026159242,-0.04992218,0.04008113,-3.5523542e-33,0.063933924,-0.048017796,0.0565672,-0.058697738,-0.0061981883,0.101142146,-0.048672885,-0.035158604,0.0078010447,0.07742371,0.0633902,-0.062776536,0.03936405,-0.015546308,-0.006938517,0.02617527,0.023653114,0.14334552,0.011044452,-0.038569916,-0.048945025,-0.014356048,0.027237212,-0.03381662,-0.007705311,0.009472229,-0.018572776,-0.0032366468,0.02858463,0.063761696,-0.033780698,-0.015092605,-0.0071761603,-0.043525226,0.06060804,0.07341129,-0.031800047,-0.017708799,-0.0048887846,-0.01301581,0.0066397134,-0.015094292,0.005288408,0.005417829,0.036190167,0.03835529,-0.09163506,0.025439596,-0.02717921,-0.0017250981,0.09291235,0.020083012,-0.04374191,0.0041289935,0.013404617,0.052641537,0.026638603,-0.045729533,0.030980937,-0.077859215,-0.032768045,-0.0838366,-0.037493307,-0.021115847,0.012901568,0.07380931,-0.014644654,0.10237572,-0.028193379,-0.06527635,0.10224903,-0.04595306,0.038009066,0.053506598,-0.079716496,0.03404642,0.02642454,-0.101660915,-0.03420376,-0.009204546,0.04234463,-0.05542779,0.0375627,0.013925706,-0.06769428,-0.08619499,0.0061239875,0.061278645,-0.014060467,0.015335471,-0.0053501357,0.060106162,-0.10500544,0.06261459,0.09859931,-3.200147e-08,0.06272879,-0.09365179,0.06322218,-0.087327175,-0.025629606,-0.007746494,0.06699785,0.031610258,0.08742537,-0.035616856,0.004917899,0.033218805,-0.0021399374,0.059349257,0.09645789,-0.02153439,-0.00065846875,0.042840064,-0.032274,0.08608781,-0.08702776,0.025932804,-0.07101738,-0.09057278,-0.025900004,-0.11483946,-0.0011456622,0.0625182,0.008863805,-0.05871545,-0.013613254,-0.011546833,-0.047342226,-0.0077986154,-0.100319974,0.010226869,-0.046384636,-0.07044098,-0.06099933,0.06679367,-0.043221507,-0.08948299,-0.049847577,0.035374787,0.031225823,-0.005703819,-0.012504242,0.07470527,0.024278332,-0.012834358,-0.053666238,0.0027385587,0.026805399,-0.13724843,-0.093065634,0.0015159623,0.028631562,-0.04385407,-0.019906487,-0.13528031,-0.011241051,0.059066013,0.14502501,-0.012993449 +1.1.1.367,Part of the biosynthesis of UDP-N-acetyl-L-fucosamine. Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.,384,1.0,-0.04832517,-0.02117294,-0.12484508,0.0026862193,0.04288171,0.019669944,-0.07487227,0.070240214,0.04392278,0.027021395,0.07397173,-0.029542096,-0.050122473,0.028622376,-0.11965997,0.031178584,-0.04589642,-0.075029746,0.05268583,0.06094244,0.0628402,0.12513356,-0.07018386,-0.048124224,0.023266803,0.031372555,0.059999537,0.04015691,0.005564588,-0.034947064,-0.037153732,-0.0018994664,0.08261359,-0.09310175,0.11539619,0.055176202,-0.015356117,-0.012537637,0.19317712,0.015666906,-0.047908258,-0.016970718,-0.00431412,-0.06319354,-0.01460145,-0.015488101,0.027709294,0.07330386,0.05647904,0.03560161,0.04333797,0.0669803,0.045256693,0.07334138,0.039247703,-0.0039459458,-0.058496825,-0.05434559,-0.1262395,0.070333295,0.0032303876,0.06210729,-0.03697306,-0.040547006,-0.02888414,0.031418286,0.04393133,-0.07949621,0.0317852,0.05541227,-0.072941504,-0.020682605,0.1079409,0.010454684,0.04112621,0.021630958,0.031673428,-0.004740473,0.013341187,0.0003851491,0.017679034,0.015147751,-0.0029321404,0.08113278,0.024758669,-0.016128095,-0.02990368,0.039962113,0.031194521,0.007868193,-0.06276057,-0.007376789,-0.016519347,-0.077112556,-0.028012732,-0.006858469,-0.0050679804,0.07391405,0.013966443,-0.023423832,-0.042062864,0.032622702,-0.004414134,-0.13042061,-0.01323759,-0.03083554,0.0050377394,0.025443118,0.036506128,-0.04031619,-0.03483788,0.06770994,-0.012776977,-0.05885788,-0.039813578,0.028766371,-0.002650468,-0.10471358,-0.056431346,-0.018429346,0.019179044,-0.0018144757,0.05008703,0.13273989,0.0019222512,-0.06069907,-0.04127934,-6.314857e-34,0.009243145,0.07184651,-0.007788115,-0.083224356,0.059872076,-0.043877084,0.011692544,-0.0833357,0.004443815,-0.0021566476,-0.06750437,-0.03300086,0.037440334,0.002572719,-0.020452188,0.027593093,-0.010263898,-0.03797213,0.08102552,-0.09812923,0.0015037715,0.11253916,0.0028725883,-0.03301068,-0.053602498,0.045108188,-0.010109804,0.051225163,0.060233846,0.004259582,0.010739434,-0.014867314,-0.04743643,-0.069718786,0.06214102,0.020765157,-0.07708104,-0.057758916,-0.0075097326,0.018494366,0.106425025,0.08159352,0.004836166,0.02876238,-0.023386363,0.057532042,-0.12078427,0.037379064,0.018398026,0.013579152,0.06929763,-0.029743483,0.051941913,-0.012342591,-0.06672518,-0.042317655,-0.08340806,-0.06327823,-0.012773149,0.14072168,-0.025014345,-0.017692016,-0.04440372,0.01916773,-0.0702632,-0.048063826,0.010226121,-0.03847773,0.06451845,0.0077155954,-0.041413072,-0.059760585,0.05504754,0.018695684,-0.0046785786,-0.008144759,-0.036172137,0.036949147,0.016397238,0.02490317,-0.05540795,-0.028668113,-0.045539763,-0.027151302,-0.028073031,-0.01573077,0.00043385572,-0.02071306,0.07200396,0.025488492,-0.049008522,-0.13383242,-0.030284982,0.03792584,0.0056294226,-2.6019637e-33,-0.003548739,-0.060854737,0.016370557,-0.03169365,-0.05438015,0.051824577,0.022423005,0.016506683,-0.02777758,0.021467967,0.082019605,-0.04365581,0.02744904,0.010675837,0.004652597,0.062046442,0.036997497,0.06978119,0.017811375,0.026572753,0.0074105198,0.023337308,0.029387146,0.023929147,0.06917583,0.07790114,0.0025667879,0.017725259,0.00202483,0.06509473,0.004070631,0.06381038,-0.052514724,-0.08854946,-0.018771684,0.027110491,0.01800507,-0.027073966,0.026323024,-0.04879673,0.07911947,0.048780363,-0.008735971,0.032654423,0.0070766304,-0.020373076,-0.07936827,-0.054838557,-0.064301,0.0036516157,0.04550419,0.03608528,0.0010278266,-0.04693829,-0.03716507,0.013664927,0.017403452,0.011607199,0.045335665,-0.015128679,-0.05223696,-0.061555643,-0.06410662,-0.04169343,0.075110205,0.01224517,0.034802765,0.022091853,0.023128211,-0.024717294,-0.021208325,0.022704773,0.0792988,0.07238215,-0.033559762,-0.01972278,-0.06755895,-0.068735585,0.023488665,0.052307367,-0.011607259,-0.060678076,0.006427423,0.039999455,-0.09182607,-0.028272366,0.101729855,0.0416057,-0.025910981,-0.020007493,0.01947177,-0.0014749132,-0.066146314,0.052332375,0.037106864,-3.00307e-08,0.06653744,-0.04013742,0.045544095,-0.020098215,-0.04041938,0.04008046,-0.03887599,0.020597953,0.01941231,-0.027417718,-0.050646447,0.12116479,-0.0034180172,-0.0025409344,-0.036670104,0.024084965,-0.0668998,0.010355253,0.008946671,-0.07601301,-0.10785762,0.0436791,-0.041847028,0.011992022,0.0013808709,-0.051112816,-0.0048465542,-0.038098026,-0.0094965985,-0.0117743155,-0.036897663,0.039504617,-0.07155193,-0.07495249,-0.08917505,-0.0029207056,-0.017901888,-0.119084746,-0.04420235,0.08246372,-0.01144705,0.006193642,-0.042458504,0.0292483,0.028524974,-0.022017399,-0.010525552,0.04687288,-0.03686656,-0.05482875,0.04024094,-0.036118403,0.009164952,-0.08175222,-0.09189206,-0.026775002,-0.03904138,-0.051303197,-0.0014663249,0.02012052,-0.111479215,0.02718969,0.14158516,0.024665456 +1.1.1.368,The enzyme participates in the central benzoyl-CoA degradation pathway of some anaerobic bacteria such as Thauera aromatica.,384,0.99999994,-0.1181173,-0.023472343,-0.07530287,-0.018145626,0.07807325,0.036409326,-0.116289675,0.025946284,0.10285154,-0.03678032,-0.02818056,-0.075594544,-0.015098885,0.04617681,-0.06493285,0.037267268,-0.056721948,0.0015132354,-0.02888552,-0.04697402,0.004588812,0.056564417,-0.02772794,0.031587195,0.011044872,-0.05496595,0.0569811,-0.03826257,-0.069297746,-0.032672945,0.03762266,0.01579669,0.07131122,-0.057068426,0.0881489,0.10374986,-0.002483509,-0.11767339,0.100888595,0.03396516,0.011133987,0.0009355643,-0.07579798,-0.051202256,-0.012394885,0.020475568,0.03260466,0.013530954,0.040795524,-0.053634588,-0.05352789,0.0061891736,-0.079185866,0.03874378,-0.009147121,0.023644442,0.01934656,-0.03162388,-0.106314644,0.04343063,0.016345188,-0.0025423993,0.026992599,0.021820167,-0.05254717,-0.06400312,0.055838887,-0.0082744,0.030188365,-0.03647445,-0.16644932,-0.07994591,-0.011547434,-0.023671744,-0.009472197,-0.003949143,0.0136633795,-0.02062417,0.016736481,-0.0699495,-0.050984472,0.011725303,0.03724901,0.03536376,0.036536098,-0.018187467,-0.020749563,-0.04543366,0.10251427,0.0744568,0.04251637,0.072446756,0.017013792,-0.051488366,-0.07793304,0.036263395,0.06650937,0.0038291195,0.010924391,-0.006204499,0.0152379265,0.06088272,-0.00052593776,-0.07900344,-0.03063755,-0.011607459,0.042709216,0.08963847,0.038037896,-0.020351764,0.0047309217,0.027363554,0.051282007,-0.019010067,0.008539678,0.047301073,0.0359309,-0.009607357,-0.085483335,0.09448437,-0.05931105,-0.07116556,0.031312585,0.022653721,0.001019342,-0.00770395,-0.078591384,3.8799726e-34,0.10015317,-0.0051401127,0.006946718,-0.00046486952,-0.01732464,-0.03421028,-0.09142466,0.010731835,-0.0017060853,-0.051902067,0.03931327,-0.086670645,-0.00826071,-0.03071135,-0.0036113402,0.029102955,-0.03554024,0.01961147,-0.008103884,0.023291506,0.025491644,-0.004568103,0.027218388,-0.043015666,0.07428685,0.07159076,-0.0007259004,0.052304465,-0.06931325,0.009537314,-0.023865674,-0.067720935,-0.12885459,-0.03534228,0.051537704,0.01576597,-0.052979838,0.034524955,-0.03431034,0.057751454,0.027565978,0.048952203,-0.01485774,-0.030296776,-0.0056370804,0.0021457938,-0.02240892,0.119394116,0.06977789,0.0052248025,0.047561716,-0.09027033,0.090437084,-0.030390285,-0.030496726,0.07748283,0.028205235,0.0068094134,0.031310946,-0.035846237,0.041388694,0.033229627,-0.09002471,0.06309286,0.06121097,-0.031602107,-0.092287086,0.030805407,0.0054517365,0.0928966,-0.048695114,0.022563227,0.03902975,0.061547406,-0.0014624605,-0.075833134,-0.097945005,-0.0179154,0.07862488,0.048999865,0.041522603,-0.052007806,0.01369787,-0.10249018,-0.021854503,-0.0035139949,0.06290522,-0.009771961,-0.008333825,-0.01340761,0.0639454,-0.10440484,0.015292114,-0.023227012,0.0156256,-2.0282942e-33,0.13042535,-0.056517947,0.012040208,-0.10363928,-0.019001791,-0.012875315,-0.029188538,0.035901107,-0.04554463,0.01687473,0.07233178,0.004432342,-0.034244344,0.034622293,0.042981174,-0.0076147607,0.081901476,-0.009919469,-0.037980307,-0.049541306,-0.05906706,-0.0370274,0.018443296,-0.083601,-0.0053325016,0.009079413,-0.08278428,0.0776478,0.005492396,0.022704106,-0.006875697,0.032984354,-0.032585308,-0.020975253,-0.024694743,0.06053947,-0.086401686,0.029355913,0.009246823,-0.015276757,0.045467176,-0.035506073,0.018288326,0.048183147,0.019589817,0.017834157,-0.09771662,-0.034237165,-0.026390977,-0.039307322,0.029946104,-0.00010397535,-0.026465863,0.028606206,0.012440338,0.064832665,-0.0039037971,-0.025827387,-0.011598217,-0.06123992,-0.038143873,0.0038384313,0.001531358,0.031297833,0.03016991,0.06001199,-0.0050739544,0.10630022,0.055689663,-0.006885635,0.10364386,0.09567048,0.04615997,0.014488864,-0.10354923,-0.037886396,-0.048230678,0.020643156,0.017566359,-0.019754302,-0.013813147,-0.05705879,-0.06491427,-0.0867655,-0.08666373,-0.09880618,0.0074966573,0.052467506,0.02692031,-0.00765014,0.022671007,-0.061618444,0.015176248,0.090287685,0.004989107,-2.3921004e-08,-0.042825703,-0.06305851,0.01081088,0.008848081,0.045586273,-0.0061925263,-0.03609796,0.012799625,0.09480336,0.001986312,-0.012124435,0.05488883,0.024568891,0.0008644075,0.024202952,0.024071796,-0.06968853,-0.0073352414,0.009765157,-0.018657511,-0.030530471,-0.018690992,-0.074062586,0.086319275,0.08493892,-0.03997832,0.01925592,0.028245246,-0.016860213,-0.011909869,-0.014364465,0.044376303,0.05082031,0.0432982,-0.03966823,-0.039271653,-0.0038483348,-0.061762277,-0.02974163,0.088504456,0.043933023,0.043019302,-0.14023946,-0.023137325,0.10221991,0.04104971,0.0045431256,0.046625398,0.0060648196,-0.0429535,0.0040224805,0.003144396,-0.035710115,0.07474151,-0.080178,0.013415669,0.051174067,0.011759995,-0.006173674,-0.022024516,0.0026920824,0.0026483552,0.15472102,-0.045819715 +1.1.1.369,"The enzyme, found in the bacterium Bacillus subtilis, also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. It shows trace activity with D-ribose and D-fructose [1]. It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.",384,0.99999994,-0.09923949,-0.014549995,-0.051166527,-0.0004483816,0.10064019,-0.039814577,-0.062552825,0.0534583,0.050868228,0.042774174,0.0023242207,-0.06307987,-0.03698657,0.037969273,-0.06633113,0.087562665,-0.030283928,0.0049958397,0.019194383,-0.058762785,0.062149387,0.066141866,-0.0152346,-0.011240329,0.067294925,-0.0285337,0.069456734,-0.00012105541,-0.07112883,-0.1094602,0.0035099955,-0.032125562,0.10372799,-0.019501958,0.04785863,0.13488601,0.038596936,-0.05433647,0.12051541,-0.00432165,-0.012906805,0.0030758206,-0.0028717346,-0.027646918,-0.018362176,-0.039267752,-0.07179375,0.084231995,0.04706226,-0.004525102,-0.025283286,0.00624781,0.012508035,-0.01085729,0.04828298,0.027399454,-0.039188232,-0.028550228,-0.014685386,0.012266961,0.0756684,0.01045325,0.008960227,0.034418963,-0.04983494,-0.06789709,0.03131173,-0.072204895,-0.010250722,-0.03684647,-0.07664523,-0.06592627,-0.041399978,0.099291995,0.036104456,-0.017680192,-0.036083914,-0.09669769,0.053823367,-0.058015328,0.024041578,0.009529776,0.0003499105,0.025107304,0.046598025,0.03234962,0.07705461,-0.049985826,0.052229583,0.04361187,0.025642768,-0.068270825,-0.012047853,-0.058799677,-0.011211939,0.01909842,0.052537795,0.052808437,0.07462043,-0.038865935,-0.011809627,0.087549314,-0.051716607,-0.040135823,-0.058037233,-0.0076581463,0.046065234,0.112703376,0.043409906,0.002803183,0.03248596,-0.09680944,0.04685925,-0.0073538725,-0.015641011,0.09453734,0.056755614,-0.045411915,-0.04985588,-0.0042924737,0.0137906065,-0.06108766,0.011255111,0.095515884,-0.06724823,0.091198966,-0.043329835,8.959219e-34,0.031063307,-0.016862525,-0.031223776,-0.002742546,-0.004761677,-0.045832936,-0.08683844,0.032636173,-0.06410617,-0.03267341,-0.09230765,-0.06448057,0.028446455,0.034429707,-0.025783759,0.017761571,0.015878148,-0.020481292,0.053601135,0.013655205,-0.03523423,0.017634673,-0.012464056,0.012568937,0.04572512,0.07395969,0.00958744,0.03807967,0.07940509,-0.013435504,0.032863572,-0.048641913,-0.10978941,0.034709886,-0.056888163,-0.012658007,-0.07191992,0.022551361,-0.02064152,0.102473095,0.030806547,0.075912856,0.0064241774,-0.08352307,-0.02025636,-0.0176704,0.020328838,0.08479401,0.03262348,0.025368735,0.04483813,0.011655832,0.07710574,-0.085355856,-0.0025738855,0.037904765,0.001149687,-0.008495394,0.07750218,0.074092075,-0.01577854,0.059111487,-0.017465463,0.07341078,-0.056629986,-0.020617735,-0.0739713,-0.0439955,-0.007967619,0.004114006,-0.0889261,0.008656157,0.071506955,-0.04243213,0.01376062,-0.015005766,-0.078204736,-0.02069871,-0.00782345,-0.024416838,0.0292535,-0.022064347,0.018155873,-0.004928346,-0.0030987302,0.056877755,-0.06642094,-0.09148938,-0.02544609,0.06887196,-0.02715767,-0.07813737,-0.09220312,0.03265701,0.057458248,-2.6269557e-33,0.07792725,-0.100082405,0.087990195,-0.13467403,-0.10564461,0.08243852,0.013397343,-0.037251603,0.07123821,0.035931613,0.068448134,0.015975181,-0.012024496,-0.03371985,0.02421856,0.013854266,-0.026850035,0.013564188,-0.05583249,0.009908081,-0.021864213,0.11442515,0.010376788,-0.048968308,0.062436447,0.037899245,0.004228906,0.023273835,0.045210417,-0.009580843,-0.008852802,-0.011923101,-0.004453649,-0.02177069,-0.048309896,0.051371824,-0.051110134,-0.029777102,0.006037696,-0.021885997,-0.05186566,0.07649584,0.031907633,0.017885156,0.028872939,0.042463213,-0.052367713,-0.0010787715,-0.035943642,-0.06690626,-0.02432493,0.0027230226,-0.005254501,-0.005453977,0.017536364,0.08370528,-0.005762314,0.06568747,-0.01972432,-0.047392394,-0.057218358,-0.048907295,0.05876911,-0.0040771207,0.07570885,0.079031095,-0.06684771,0.07386533,0.0003856651,-0.0377915,0.065843865,-0.042697024,-0.027346184,0.03632912,0.006603436,-0.053698976,-0.09185725,-0.033670846,0.015700549,0.0010136728,-0.04080411,-0.017774396,-0.093247615,-0.058174558,-0.03526958,-0.09251585,-0.0057000923,0.11758675,-0.036183167,0.05884663,-0.040678754,0.029170744,-0.029059043,-0.00529386,0.06581765,-3.8644043e-08,0.032008074,-0.0892942,0.052402094,-0.034601074,0.0753885,0.021474203,0.014122153,0.054072153,0.07222304,-0.033375412,-0.067169756,0.116161786,0.04938439,-0.020650856,0.029514767,0.014395106,-0.05027198,-0.020924283,-0.0054032155,-1.1917644e-05,-0.042882025,0.00064015115,-0.086159125,0.013368117,-0.026465926,-0.10284465,0.07002715,0.033277772,-0.028606668,-0.03147653,-0.07781963,0.06781673,0.021293184,-0.040197495,-0.002115596,-0.008384185,-0.08062395,-0.0057724304,-0.036270026,0.041100416,0.056250945,-0.017943958,-0.051579725,0.012215458,0.012723411,0.06308612,-0.016618991,0.031501345,-0.0151651,0.018485753,-0.012885975,-0.0033030447,-0.016641328,-0.012196586,-0.06929792,0.011774839,-0.041808277,-0.082715094,0.023695178,0.008377992,0.029956289,0.00014454243,0.1482467,-0.035811923 +1.1.1.370,"The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC 1.1.1.371, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA.",384,0.99999994,-0.11137428,-0.01742363,-0.06934283,-0.011769783,0.057621945,0.04158549,-0.13776009,0.030364992,0.017176582,-0.022579953,0.023709819,-0.046294503,-0.02791993,0.07907553,-0.062083114,0.06316199,-0.025220364,-0.04267773,0.07417962,-0.034868814,0.011462051,0.06079129,-0.01835232,-0.00489694,0.10746416,-0.019090176,0.027407698,-0.023200896,-0.06733871,-0.033191346,-0.031505533,0.039666895,0.012087308,-0.07774879,0.09253873,0.08912244,-0.00063012604,0.010776187,0.08520871,-0.015421805,-0.01092325,0.008517359,-0.10369971,0.011664925,-0.044766515,-0.036608577,0.004234417,0.034907203,0.025727192,-0.020490093,-0.066896826,0.02227375,0.031584267,0.011849666,0.026746547,-0.053552926,-0.007866328,-0.017453872,-0.0198759,-0.06193498,0.042129565,-0.06530726,0.011979141,0.035256483,0.015703656,-0.03721119,0.08404252,-0.03883288,-0.050800733,-0.01748905,-0.109024465,-0.02265242,-0.0044476236,0.115986,-0.0060574845,0.0080204895,-0.0559517,-0.06967646,0.09805584,0.004614314,0.022543032,0.011601816,-0.054192625,0.07722999,0.08657555,0.0055977097,0.02743995,-0.006425578,-0.016518153,0.002935269,-0.014277512,-0.033633485,-0.040669054,-0.032100257,-0.08974807,0.020739842,-0.0055323895,0.0064299107,-0.029387293,-0.0375358,-0.005438735,0.11945787,0.014484448,-0.029907452,-0.019521605,-0.0010063421,0.00870669,0.09679223,0.0018713747,0.02106006,0.029697873,-0.058818467,0.04847062,-0.085983016,0.016564677,0.07602293,0.003809239,-0.010261108,-0.09378876,-0.0018162235,0.008239677,-0.0455266,0.02649897,0.06469946,-0.03256798,0.027720017,-0.057108283,1.4311958e-33,0.07785993,-0.015729766,0.010514161,0.02003747,0.03812183,-0.016550507,-0.057823326,0.07238656,-0.05967134,-0.055558756,-0.043830443,-0.11650862,0.03352118,0.017311785,0.010106138,0.064678654,0.0023681337,-0.09718064,0.032482084,-0.007983542,-0.026996497,0.052873377,0.0023736795,0.034634624,0.030057888,0.038060915,-0.025791897,0.053248744,0.017637745,0.0035245132,0.09558307,-0.06296723,-0.15282181,0.022983314,0.030150265,-0.011587902,-0.060924713,-0.034471333,-0.042893484,0.07409559,-0.03351771,0.11818864,-0.004792108,-0.04997344,-0.0029283797,-0.081562154,0.003176547,0.07261147,0.021210155,0.048911348,0.046843108,0.021027012,0.075774685,-0.10367171,-0.00018534335,0.08596304,0.028590979,0.014330136,-0.0066221734,0.058874313,0.0471065,0.01351531,-0.028042288,0.066421926,-0.04937253,0.049345355,-0.109606735,-0.07604172,0.054877684,-0.002576651,-0.012928773,0.07313145,0.042587303,0.03870272,-0.024302648,-0.045524098,0.015294576,0.0028095378,0.023855994,0.021768535,0.0047904574,-0.099564634,0.01829681,-0.002720123,-0.010135262,0.048145715,0.013288095,-0.039123,0.015830537,0.03698393,0.06302417,-0.057153575,-0.045705173,0.007014154,0.0649376,-3.162795e-33,0.092377946,-0.062125318,0.0514358,-0.15291914,-0.09840609,0.109429516,0.01607347,-0.07141329,0.0031960374,-0.015954616,0.10760144,0.049086,0.0022688531,0.0097132195,0.06969001,0.02398175,-0.0044316114,0.025740884,-0.03702705,-0.0074505676,0.011925839,0.13117811,0.07025505,-0.05920958,0.023152268,-0.0056478987,-0.060579482,0.0405605,0.015747668,-0.011364726,-0.00094720215,0.040776324,-0.08668434,-0.044544507,-0.029440433,0.025898797,-0.07090127,-0.0076910253,-0.0139851365,-0.00828385,0.010953173,0.070581496,-0.068068765,0.026493717,0.056163806,-0.0058549,-0.058830623,-0.011033047,0.031033374,-0.10774997,0.0079756975,0.045173723,-0.037701927,0.0014861326,0.07911009,0.07339836,-0.030710356,0.066114515,0.052624255,-0.091141135,-0.06546179,-0.004041831,0.0045591914,0.008354863,0.09376753,0.09312779,-0.041046824,0.031891245,0.04881071,-0.086458735,0.033986133,-0.015557834,0.0031772002,0.024813121,-0.033178784,-0.00073289784,-0.12534079,0.009310855,-0.034424707,-0.008889505,-0.01709367,-0.027021239,-0.07847715,-0.041839853,-0.03166705,-0.051466838,-0.03421831,0.056903843,-0.0007744581,0.016385594,-0.016770206,0.08308754,-0.029381132,0.027610375,0.007265121,-3.6129926e-08,0.056574933,-0.021814413,0.02821355,-0.059042823,0.047414083,0.003996242,0.025805186,-0.0475722,0.07510783,0.029846298,-0.049681053,0.1281875,0.018491294,0.023229508,0.015696222,0.0064847,-0.03210438,-0.04280563,-0.009408857,-0.052707605,-0.07869567,8.086528e-05,-0.04811084,0.08242612,-0.020093208,-0.07127497,0.0085921,-0.03483893,0.052168403,-0.0783954,-0.025672251,0.04465835,0.049314726,-0.024371177,-0.024514114,0.02191716,-0.06705527,0.03262304,-0.06339148,0.092875026,0.023350237,-0.064592004,-0.039198842,0.00885941,0.036564384,0.0886063,0.03786781,-0.0096101705,-0.079460464,-0.039221182,0.009043348,0.02066753,-0.003539472,0.009686047,-0.06578141,0.026658846,-0.00053895765,-0.06669242,0.004113487,-0.015740082,-0.009081548,-0.031042475,0.0697012,-0.03207372 +1.1.1.371,"The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)].",384,0.99999994,-0.07894725,-0.03894313,-0.098307945,-0.02374204,0.0065040053,0.03981364,-0.13198727,0.018540941,0.018939672,0.015737463,0.031264506,-0.07145431,-0.014190241,0.074898645,-0.033141892,0.04694521,-0.041670047,-0.040758435,0.06535054,-0.034009468,0.04116711,0.05378528,0.01530889,-0.0025284223,0.08646683,-0.012023697,-0.0033761838,-0.031124584,-0.045666765,-0.03278587,-0.0460038,0.016123747,0.03668572,-0.06070654,0.086079404,0.057410058,-0.041106075,0.034614123,0.0792678,0.014051269,-0.03453011,0.0106561985,-0.066964924,0.0112806745,-0.048209157,-0.031681605,0.027360592,0.018891208,0.044030227,-0.0046315943,-0.07115733,-0.0052514705,0.021922478,0.006347445,0.05759086,-0.040829096,-0.014987979,0.015862627,-0.024307707,-0.059007417,0.05052935,-0.07636096,0.015010326,0.021461798,0.009575639,-0.03776767,0.05893774,-0.03631493,-0.043743018,-0.046809636,-0.09955136,-0.007656654,0.020166818,0.087250784,-0.009428634,0.021353036,-0.066882126,-0.050287448,0.06490013,-0.0032902663,0.023252197,-0.036987733,-0.06659662,0.07643521,0.0720606,0.0070802774,0.027346997,0.016389456,-0.009673141,0.011306793,-0.009432441,-0.01816546,-0.05882176,-0.036280744,-0.078479685,-0.008590839,-0.005575176,0.060202584,-0.016769402,-0.058082383,0.016274242,0.107770465,-0.026065765,-0.012950188,-0.020887017,0.03094095,0.025330873,0.10440785,-0.031028962,0.026698202,0.029024193,-0.03632089,0.08015225,-0.0657456,-0.038487244,0.060616985,0.051279344,-0.039544526,-0.12022184,-0.03200401,0.026891138,-0.023348682,0.03992336,0.03280302,-0.058691412,0.03779784,-0.06379098,-3.555637e-34,0.0758055,-0.005869268,0.016661832,0.032922566,0.022386454,0.037149977,-0.056284122,0.07753622,-0.054666307,-0.052100856,-0.060098484,-0.07137952,0.050334476,0.014530678,0.033653345,0.07998092,0.05381331,-0.13460237,0.018804101,0.0035703785,0.033437226,0.044186734,-0.018776389,0.029040355,0.034706976,0.03485809,0.024949627,0.0137084965,0.008602386,-0.006255492,0.05961445,-0.11830776,-0.10792989,0.038424652,0.06111047,-0.027633915,-0.06588631,0.012718958,-0.05026774,0.045716763,-0.07900545,0.09873244,-0.0034475196,-0.08823126,-0.0034138055,-0.095132075,0.025350312,0.07197108,0.025721787,0.08440785,0.04174967,0.014572561,0.06091744,-0.09594199,-0.0067907805,0.089005545,0.05092498,0.047955602,-0.02418964,0.0682583,0.02580844,0.016573269,-0.026689304,0.046851322,-0.044378184,0.034252457,-0.13034612,-0.05564614,0.022906367,0.011855606,-0.0088081295,0.0643422,0.041020453,0.02206302,-0.012161856,-0.028960602,-0.016967436,-0.04148251,-0.0005580042,0.0019750474,0.03411881,-0.08527946,0.0367302,0.02110652,-0.02488867,0.054232825,-0.016014721,-0.020463001,-0.009157644,0.042151097,0.04051097,-0.09084116,-0.059449505,-0.020057313,0.088555306,-1.7362588e-33,0.084003896,-0.024279611,0.050768718,-0.15798545,-0.08482594,0.13692842,0.032510087,-0.07319663,0.015038818,-0.03194393,0.10412293,0.06499448,-0.0037375272,0.0006430194,0.073049664,0.02695068,-0.03999902,0.048430048,-0.025668176,-0.008827035,0.0069009936,0.15504631,0.03287574,-0.05439136,0.013502537,-0.0053128097,-0.04245033,0.09602634,0.0025351564,-0.0033820579,-0.013166717,0.008516178,-0.046990804,-0.05712662,-0.01225686,0.008128311,-0.05337628,-0.042214386,-0.006259222,0.0032109972,0.006682856,0.048897844,-0.039708726,0.040339835,0.062422648,0.020407477,-0.090173624,-0.022706116,0.046693794,-0.07911008,0.006326831,0.007401575,-0.027405135,-0.022044647,0.1304568,0.026270017,-0.022758143,0.052520417,0.045840696,-0.07359383,-0.028611783,-0.015199724,-0.005329483,-0.018376032,0.031382877,0.07822328,-0.055521283,0.0495752,0.06504225,-0.09067281,0.05781305,-0.010976761,-0.042618707,0.013729468,-0.04864766,0.014303503,-0.12312635,0.0029813664,-0.016540268,0.002471125,-0.019016705,-0.008058496,-0.0456643,-0.06283064,0.048577026,-0.0188128,-0.0206329,0.029088836,-0.032318242,0.026444577,-0.025844311,0.08351636,0.00032149482,0.037512504,0.0046961657,-3.2695265e-08,0.066236384,-0.024175677,0.02741398,-0.054318164,0.029277926,0.018017674,0.03515778,-0.054125864,0.048274312,0.04343518,-0.034644086,0.06880515,0.008132115,0.052166592,0.026240163,0.028645977,-0.0472632,-0.055672962,-0.03578932,-0.035718653,-0.07436092,0.006503148,-0.10995547,0.09181252,-0.022083562,-0.07236947,0.029563524,-0.06863529,0.04232294,-0.08729939,0.0023197825,0.03563014,0.04293454,-0.021436337,-0.07658096,0.008081576,-0.04603295,0.0664291,-0.07151951,0.06504758,0.04110087,-0.07611227,-0.042202983,0.024483783,0.031089969,0.0787958,0.011548021,-0.021095112,-0.05738326,-0.017479425,0.04641361,0.035968315,0.01707592,0.02477884,-0.08343077,0.058760274,-0.0095292,-0.041263122,-0.001954933,-0.025530955,0.043606266,-0.056768782,0.07499723,-0.025711393 +1.1.5.10,"The enzyme from mammalian kidney contains one mole of FAD per mole of enzyme.(R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors. ",384,1.0,-0.006456885,-0.048376307,0.003816869,-0.04674604,0.06359946,0.018840179,0.02852251,0.05508574,0.06156683,-0.017371783,-0.04152974,0.004667556,-0.06988904,0.057575,-0.10050927,0.0048077167,-0.07654394,-0.038703963,-0.0063694394,0.022528697,0.035965454,-0.02637237,-0.023991873,-0.058733515,0.053559326,-0.035918772,0.08694627,-0.022847522,-0.019594254,-0.04585356,-0.050944973,-0.07444094,-0.042417627,-0.021989794,-0.021171896,0.04240412,-0.02129709,-0.03978373,-0.053873464,-0.0038323482,0.05330164,-0.038019303,-0.022585697,0.05143442,0.0015341103,-0.048607767,-0.02632199,0.044865455,0.053227015,0.06995551,-0.05029041,0.04715367,-0.022073187,0.100543864,0.011240947,0.032539874,0.0023988497,-0.0020906527,-0.01533549,-0.086907566,-0.04752084,-0.035035156,-0.002567147,-0.051199183,0.07729072,0.011778144,-0.009476348,-0.072087236,0.0044325693,-0.090578616,-0.019347424,-0.0471899,0.029651675,-0.03566967,-0.011888675,0.06886469,-0.08000218,-0.008249577,0.038428005,-3.4066066e-05,0.0313157,-0.016981449,0.073090255,0.069158845,0.071503066,0.0072047976,0.00086756086,0.041641645,-0.044375755,0.053137533,0.018263787,0.00061664503,-0.026172983,-0.034576602,-0.09432041,0.016678918,0.05629752,0.017540347,0.013936707,-0.025269475,0.022221195,0.05907157,-0.00085875293,-0.08545457,-0.12457069,0.04882274,-0.045515705,0.06423344,-0.003970681,-0.00824302,-0.038276583,-0.006004925,0.036880072,0.064471565,-0.006634188,0.014951479,0.055030458,-0.11416655,-0.07246675,-0.0011105958,-0.054980956,0.04597933,0.07519674,0.08388482,-0.0068002604,0.05062561,-0.050358765,2.5690574e-33,0.08904987,0.019779889,-0.010178247,-0.028854588,-0.02710144,0.09245992,-0.07183406,0.05589609,-0.019048303,-0.118893735,-0.05659454,-0.033726957,0.023964837,-0.018359317,0.0061632236,0.05354778,0.024323814,-0.038046785,0.09530401,-0.09427758,-0.003441701,0.08239423,-0.0021566781,-0.012203861,0.03278883,-0.053986937,-0.098053426,0.12648277,0.018042201,0.00061329396,0.012373675,-0.07658985,-0.03264021,0.032530077,-0.03368871,0.026768224,-0.057436943,-0.06591768,-0.030784484,-0.004946106,0.020174565,0.022662668,0.038690303,-0.03216554,0.09098836,-0.05722578,-0.07169767,0.0032729683,-0.05627393,0.094595775,-0.026019208,-0.0034292007,0.04439592,-0.07278352,-0.066187605,-0.008138406,-0.051405035,-0.0069380696,0.025728235,0.060991995,-0.04964418,0.074592195,0.011965498,0.07767423,-0.034803595,-0.010844493,-0.08324259,-0.029025195,-0.018235303,0.08873928,-0.04120035,-0.048665725,0.07812426,-0.0109713515,-0.011825654,-0.07983056,0.04075642,-0.052668355,0.03847094,0.015243412,-0.058593553,0.006580418,-0.045204353,0.010679657,-0.040731236,0.040595777,0.03856047,-0.091896415,0.0242929,0.029544206,0.03856559,-0.05634109,-0.14431627,-0.009884042,0.05549645,-4.5961326e-33,0.090188816,-0.116047546,0.104450606,0.0038307407,0.025009466,0.072451174,0.0721236,-0.04703099,0.10351312,-0.026953507,0.08429518,0.0070147975,-0.0017050144,-0.035968795,0.025909826,0.007337859,0.027741175,0.08283327,0.07424136,0.016237447,-0.0126032485,0.061022565,-0.008961717,0.088768005,-0.003954181,-0.023354977,-0.0068389634,-0.056626502,0.058097016,0.0117918,0.035233416,0.08115675,-0.022733415,-0.052443795,0.008586467,-0.017535102,-0.015978368,-0.018539472,0.02570435,0.099233255,0.00358092,-0.007118157,-0.046820354,-0.0017695444,0.0011231304,0.016745007,-0.036417227,-0.021952854,-0.00046222747,-0.10561534,0.055428706,-0.016814359,-0.04794386,0.0035755385,0.0873764,0.03580883,0.088593744,0.05143909,0.031045267,0.031581547,-0.0074042296,-0.014106553,0.004530944,-0.052340057,0.025410876,-0.025590127,0.014443635,0.074203566,0.0045780246,0.00149256,0.1281593,-0.005978292,0.06391508,0.089890316,0.017855221,-0.025711592,-0.044777643,0.022334244,0.0049225576,-0.040498767,0.03172852,0.05803239,-0.051588476,-0.009410983,-0.051027194,-0.019122634,0.047383316,0.10362286,-0.036402185,0.029811276,-0.026052468,0.03551954,-0.086169265,0.006278369,0.09930323,-4.296909e-08,0.0805208,-0.023309777,0.058630005,-0.051179223,-0.048771277,0.030846199,0.030542603,0.045741502,-0.009976129,0.04865361,0.0012940265,0.06669341,-0.022392973,-0.028847525,0.037809357,0.0005256582,-0.03714715,-0.04074454,-0.059972722,0.026843946,-0.073392175,0.036194492,-0.11063817,-0.018921394,0.040821943,-0.065912485,0.01396446,0.011665029,-0.05998946,-0.031960227,0.044194683,-0.038296543,0.022437494,-0.09301445,0.00885436,0.06853609,0.075853676,-0.071519665,-0.046021383,0.027145784,-0.020825956,-0.08608154,-0.010054941,-0.043132205,-0.0093176,0.009148511,-0.013442692,0.002652574,-0.08941659,-0.028284863,-0.0030953481,-0.058218606,-0.030815702,-0.09683236,-0.048835676,-0.0026874891,-0.033353858,-0.03878939,0.016793722,-0.11799063,0.07650549,0.03140606,0.10639102,-0.04942312 +1.2.1.89,"The enzyme from the archaea Thermoplasma acidophilum and Picrophilus torridus is involved in the non-phosphorylative Entner-Doudoroff pathway. cf. EC 1.2.99.8, glyceraldehyde dehydrogenase (FAD-containing).",384,1.0,-0.049341563,-0.026855307,-0.12858318,-0.03121119,0.081962444,-0.0013556908,-0.108091824,0.0022104208,0.05509463,0.022623904,0.041247334,-0.029119305,-0.014248088,0.042166572,-0.054682225,-0.011061402,-0.10403488,-0.008067548,-0.0019798253,-0.029164769,0.042758178,0.0757719,0.012010654,-0.013789519,0.0043517444,-0.031413905,0.042170398,-0.027577465,-0.07609346,0.01878477,-0.0019828633,-0.04758111,0.03997459,0.026509136,0.017541345,0.117480926,0.0005538812,-0.010595189,0.033328347,0.012634207,0.048951965,0.019414365,0.009892247,-0.0050572273,-0.06388605,0.03893275,0.027498763,0.0012804379,-0.0035928262,0.031508323,-0.041090164,-0.010468236,-0.041793406,-0.0064787683,0.023001527,0.06400954,0.024472388,-0.049011547,-0.012266966,-2.381619e-05,0.020268513,-0.027309826,0.0013734882,0.05593234,0.0040856125,-0.10046503,0.08240953,-0.032092832,-0.059065703,-0.04941616,-0.028252473,-0.0171518,-0.025803283,-0.017656712,-0.020236935,0.11508778,-0.026903965,-0.052574888,0.058654733,-0.056288872,0.07114927,-0.009080455,0.0036125921,0.06724809,0.0074263928,-0.047271665,0.0850765,-0.0049638115,0.04495762,0.03097137,-0.0069275466,-0.042760227,-0.036076542,-0.06272568,-0.048669096,0.032021623,0.024624992,-0.0036964007,-0.022866616,-0.065859996,-0.07386457,0.0014345484,-0.011646759,-0.02984414,-0.08870219,-0.03541385,-0.029174903,0.08581893,-0.0022285427,-0.009103164,0.025135815,-0.013839471,0.098340616,0.021267794,0.01871654,0.0102541195,0.061893426,-0.12431537,-0.07160386,-0.03292914,-0.06242723,-0.014732766,0.029675253,0.07434743,-0.06460243,0.015647616,-0.087931335,2.1842206e-33,0.09757275,0.024053348,-0.00082668476,-0.03002051,0.053863153,-0.013349377,-0.09953597,-0.0040693516,-0.053616144,0.006109481,-0.01958056,-0.00599461,0.066927664,-0.004546811,-0.0519436,0.034271445,0.016010124,0.012926172,-0.0053652227,-0.01203036,-0.0019740984,0.095097035,0.05288284,-0.0338123,0.06723356,0.07965559,0.009627314,-0.034997243,0.07793147,-0.01961228,0.050334986,-0.16319561,-0.13992459,0.04255213,0.06653034,0.02175187,-0.06174791,-0.027353609,-0.08429042,0.0007378732,0.0067322995,0.04671505,-0.01760245,-0.035397198,0.0023246803,-0.02203513,-0.013829368,0.05966008,0.015165936,0.13150436,0.039405897,-0.024234112,0.10141409,-0.06421645,-0.11140769,-0.025573667,-0.06400353,-0.015100106,0.04947146,0.059528846,-0.01119461,0.055192538,-0.038494408,0.05434923,0.022613948,0.0010347846,-0.062521555,-0.067553334,0.02581871,0.05860183,-0.029360896,-0.0031162759,0.02819692,-0.008077806,0.0016660423,-0.014580928,-0.043504883,-0.056863613,-0.07552038,-0.016806688,-0.049080063,-0.027745973,0.051819783,0.0037311395,-0.014495242,0.025951259,-0.035708304,0.04157709,-0.01978997,0.029006658,0.060843546,-0.049376663,-0.012813464,0.052192956,0.051024023,-2.8647212e-33,0.09448693,-0.09840889,0.05932283,-0.11855966,-0.031796552,0.13084073,0.016558845,0.024216102,0.01105124,-0.036353618,0.05991829,0.019981159,0.043993156,-0.081081994,0.076087795,-0.062240265,0.04612606,0.054611284,-0.013900802,-0.025806746,0.033086896,0.060861193,-0.03749846,-0.028095089,0.047983844,0.051240373,0.028104754,0.07860017,-0.070066154,-0.0024935587,-0.0064148935,0.09535261,-0.05933973,-0.031889305,-0.044777684,0.051877882,-0.019152954,0.044457123,0.0070744716,0.010149286,-0.007332003,0.016629104,0.00447673,0.08267686,-0.0052663283,0.029022876,-0.12996274,0.03581042,0.07261836,0.0246128,0.01301239,-0.018631535,0.0011197475,-0.026766175,0.08549069,0.022581981,-0.035008736,0.06470104,-0.026704205,-0.069865696,-0.014261554,-0.080340184,0.032142367,0.027609674,0.03451722,0.06733957,-0.0123857735,-0.0087660905,-0.00036563797,0.008470318,0.0588055,0.041462436,-0.026511336,0.035335295,0.040294975,-0.016755689,-0.048147142,-0.012708132,0.0818113,0.040177226,-0.012999596,0.04322401,0.009203251,0.011109485,0.04395292,-0.08964477,0.037483748,0.058062896,-0.0062884586,-0.018235555,-0.02405453,-0.030996718,-0.0074690073,0.007957494,0.055117454,-3.4663856e-08,0.034884106,-0.03715361,0.027716689,-0.07178892,-0.008938474,0.027476067,0.026559224,0.068457745,0.04601162,-0.03857141,0.08683656,0.075880565,0.06018162,-0.005885903,0.030528465,0.03974982,-0.055189077,-0.02405987,-0.039170526,-0.007984777,-0.06856085,-0.035738777,-0.1334268,0.088172965,0.020375583,-0.015465361,0.008939943,-0.034341283,-0.021702742,-0.047610775,0.0038587027,-0.029952437,-0.02193329,-0.046419065,-0.08791849,-0.017818518,-0.0037544048,0.004270551,-0.058854777,0.034311816,0.029530365,0.032510053,-0.02239124,0.01521009,-0.036511596,0.05507746,-0.026387243,0.023175998,-0.058967687,0.048225332,0.037606947,0.036975715,0.00886993,-0.04186401,-0.17358315,-0.09326181,0.044563636,-0.0984305,-0.08416156,0.039439168,0.04283738,0.009815452,0.18128893,-0.0080078235 +1.3.1.106,"The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of cobalt-precorrin-6A. The enzyme from the bacterium Bacillus megaterium has no activity with NADPH. See EC 1.3.1.54, precorrin-6A reductase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.",384,1.0,-0.059843298,0.051443532,-0.08316929,0.022774726,0.027960692,0.08953932,-0.12580074,0.019606818,0.058292124,-0.0058536488,-0.023807993,-0.024559911,-0.038386982,0.005249028,-0.009201081,0.03396314,-0.0720738,-0.0035743015,-0.037062276,-0.014416642,0.008166734,0.023674123,0.0045720404,0.024493093,0.06319781,-0.05054816,0.032734543,-0.021931076,-0.05187061,0.028387228,-0.015654776,0.0065304735,0.06580306,-0.0054499106,0.030732658,0.10699024,0.009779511,0.022710668,0.06096452,-0.003100728,-0.006665272,0.038972463,-0.012394161,-0.019702967,0.007591007,-0.0045842053,0.0076110326,0.06680081,0.017333673,0.0028648465,-0.057883296,-0.023470007,-0.049218252,-0.02830255,0.0589987,0.016108047,-0.07264856,-0.06294231,0.0824448,-0.034242075,0.033309765,-0.1042406,-0.0035496042,0.048506387,0.040725112,-0.042218793,0.0763929,-0.056844495,-2.8458155e-05,-0.10007756,-0.06292635,-0.052344766,0.012241129,-0.04054418,-0.034078736,0.077515885,-0.029549815,-0.053250212,0.0317199,-0.024689779,-0.012776569,0.0067368546,-0.010886696,0.06603937,0.06098827,0.012752333,0.040981695,-0.018881274,0.020936238,0.06526113,-0.016023021,-0.0006743008,0.013181492,-0.023657484,-0.2011687,-0.03794966,0.04302485,0.049130127,0.00331055,-0.008571363,0.085132584,0.108292304,-0.027125709,-0.03773769,0.013129821,-0.038409583,0.04606451,0.17332633,0.042728145,0.04778072,0.029830897,0.06286326,-0.015344702,0.01517322,-0.031134376,0.1431641,0.01725486,-0.044033453,-0.13694912,0.02212272,0.029490467,-0.026538672,0.00037369336,-0.009478388,-0.040757105,-0.053500567,-0.035100173,2.7807092e-33,0.078544654,0.0013819479,0.02589683,-0.018463451,0.027790502,0.027890466,-0.12748893,0.05155438,-0.0001487996,-0.048659384,-0.025976146,-0.06355649,0.045370817,0.024193026,-0.019935356,-0.006533707,-0.008706447,-0.08094344,0.048066955,0.036295403,-0.005153059,0.06529198,0.00521582,0.0482392,0.020273399,0.010624968,-0.0035152354,0.044593807,0.013840171,-0.008428935,0.015445289,-0.07602583,-0.097947486,-0.034640208,0.043439306,-0.02903671,-0.07553393,-0.016506584,-0.038507763,0.04337285,-0.026603973,0.06736268,-0.10511721,-0.041497335,0.06156623,-0.10145554,0.0038156104,0.10576573,0.029451836,0.048390836,0.011259872,0.022629458,0.1091991,-0.004430464,-0.016534442,0.06712647,0.0015445594,-0.0042603207,-0.0044513578,0.09400024,0.09922504,0.024285862,-0.020603957,0.12868515,-0.045486532,-0.013668826,-0.050670307,-0.035304334,0.043392804,0.028369296,-0.031141557,0.023428548,0.047197957,0.045597717,-0.023859829,-0.02872531,-0.028082695,-0.057510607,-0.0036559536,-0.066923566,0.006390315,-0.001566648,0.03345755,-0.06660768,-0.064789936,0.06613881,-0.031074585,-0.04415421,0.014615061,-0.032201238,0.032065462,-0.076201476,-0.10171994,-0.02399768,0.03422149,-3.4484144e-33,0.1488078,-0.062419243,0.11229896,-0.15704021,-0.026985308,0.058689024,0.06566317,-0.10803476,-0.019101229,-0.081579424,0.06441303,0.012422636,0.0466348,0.017438242,0.04551107,0.00800608,0.01631956,0.08001757,-0.003954616,0.015628401,-0.04747196,0.04309329,-0.007519094,-0.05847046,-0.0067830184,0.03626982,-0.021455586,0.040002186,0.04689098,0.019074721,-0.028172078,0.03658825,-0.007321206,-0.05562888,0.0035598394,0.07924979,-0.016812436,-0.007611204,-0.021733588,-0.00052010285,0.0027062187,-0.0042288415,-0.07990938,0.042637262,0.04027052,0.05453267,-0.0823131,0.028601544,-0.0220265,-0.026095556,0.06800229,-0.0060571,-0.053626236,0.01583621,0.10639303,-0.0030658653,0.019871982,-0.04345315,0.027024481,-0.11669512,-0.030083535,-0.031368297,0.013495284,-0.04595085,0.050452236,0.022412267,0.030007185,0.07880794,0.053905293,0.0027696274,0.07220781,0.08470082,0.005267108,0.009732341,-0.08818632,0.0043392004,-0.0016458296,-0.035367586,-0.005361117,-0.02510972,-0.051098786,0.027633043,0.0189679,-0.043719966,-0.040667,-0.024756983,0.059932347,0.014817859,-0.06842637,0.051684298,-0.06433131,0.0052329786,0.017939517,0.0051410277,0.021815974,-3.5943756e-08,0.06889632,-0.089907,0.010806314,-0.008330348,0.02496146,0.028620703,-0.010279349,-0.031626962,0.01071436,0.019090774,0.0039298343,0.08489308,0.03846564,-0.061753184,-0.044612326,-0.032938696,-0.06665373,-0.025136001,-0.034906562,-0.0050844033,-0.08201091,0.03419896,-0.06952146,0.041987654,0.060239553,-0.111303985,-0.022953482,0.024739739,-0.028371118,-0.015898947,-0.0015376883,-0.047157012,0.066413656,-0.060061403,-0.0048593744,0.00063247874,-0.028686685,0.01290076,0.0059920577,-0.0059717386,0.0054244017,-0.090224475,-0.06054784,0.02935629,0.011763942,-0.009641139,-0.041110996,0.039568216,-0.07137767,0.010201201,0.008267337,-0.015412476,0.008233592,-0.0039181914,-0.053335443,0.08053164,-0.013605128,-0.08133566,-0.053496134,-0.010234618,0.04256016,-0.0075492035,0.07671873,-0.1029285 +1.3.98.2,"The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)], EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)], and EC 1.3.5.4 [fumarate reductase (quinol)].",384,1.0,-0.057245888,0.053655796,-0.15846653,0.0076266695,0.093110316,0.0046451157,-0.10526394,0.04051745,0.018578896,-0.020944733,-0.03620065,-0.10233555,-0.09116864,-0.023826351,-0.07028591,0.024972096,2.296106e-05,-0.013044255,-0.0045727286,0.013328019,0.06629235,0.04904974,-0.0067503206,-0.025382422,0.03109061,-0.017333306,0.014305085,0.022143278,-0.055089794,-0.06084309,0.013868014,-0.058545712,0.10101226,-0.05619169,0.043742403,0.110060975,-0.046504453,-0.10265382,0.024078077,0.040635537,0.011019066,0.02589752,0.02851158,-0.0075134994,-0.0524013,-0.0106877405,0.020998066,0.028295038,0.043445695,0.022584734,-0.04036796,-0.058089964,-0.06185929,0.01969154,0.02672583,0.044932336,-0.0041905227,-0.02677494,-0.059761558,-0.06640552,0.04838598,0.021905033,0.007124827,0.017121589,-0.019164627,-0.0062050554,0.004728138,-0.083101325,0.05119218,-0.05974527,-0.025446458,-0.0010237028,0.01958579,-0.017466672,-0.07347422,0.039824057,-0.019034564,-0.049222153,0.08264919,0.004983416,0.01579885,-0.08671391,-0.0135917645,0.015456995,0.061339673,0.017862627,0.003521675,-0.00883796,-0.0073133293,-0.00529152,0.04599353,0.006103693,0.025335642,-0.039626896,-0.1024222,0.040260423,0.0586779,0.10314034,-0.027660808,-0.014910245,-0.0007570954,0.08602741,-0.0135738645,-0.095089786,-0.12182608,-0.0031958616,0.038710136,0.080530755,0.031026017,0.024742786,0.0027703168,-0.042247523,0.069239646,-0.033246018,-0.025972836,0.09213,0.0031210354,-0.096415594,-0.09628719,0.030988408,-0.008138777,-0.019920522,0.13786083,0.025824536,0.037491284,0.014821159,-0.11902611,4.826747e-33,0.093706064,-0.00019354689,-0.030535478,-0.03616052,0.021207018,-0.00731579,-0.082222246,0.022120846,-0.073549956,-0.011391587,-0.06591125,-0.0034848528,0.09087465,-0.0663669,0.005134245,0.031882633,0.019135855,-0.08514271,-0.0073308386,0.021025734,0.021581639,0.02354821,0.005772919,0.02147754,0.028503196,-0.0019131028,-0.00976917,0.032524247,0.021671927,0.028355343,-0.00736942,-0.1271246,-0.12112459,0.012519035,0.03515586,0.020067023,-0.11080992,-0.020683711,-0.089372754,0.0076145898,0.01987072,0.048190307,0.04329694,-0.031298243,0.14201537,-0.012621319,0.0035569689,0.13965051,0.06600112,0.07047788,0.010333988,0.0019360437,0.08242086,-0.02343192,-0.056569047,0.0020998444,0.0016620138,0.04265389,0.026197216,0.07732325,-0.0066836723,0.062976,-0.016119601,0.08735067,-0.026527213,0.060594853,-0.049543083,-0.030750278,0.02712789,0.04976176,-0.0007980259,-0.020069486,-0.0022517093,0.014232369,-0.012763577,-0.028385751,0.057516627,-0.03782392,0.022553308,-0.0458641,0.021373436,-0.010796268,0.028227985,-0.014055894,-0.034885917,0.012062552,-0.028268307,0.022855883,-0.004427943,0.077708736,0.07514445,-0.097170666,-0.054334715,-0.067391634,0.030887274,-3.6245935e-33,0.050261226,-0.06588025,0.008163129,-0.10461742,-0.033593196,0.13145325,0.020330714,-0.0155622475,0.037460543,-0.054202106,0.096448325,0.0012150864,0.051986314,-0.09839302,0.08107843,0.0063920245,-0.02154329,0.031443913,0.025099123,-0.011022822,0.039216574,0.08020986,0.006341479,-0.05574665,0.025290564,-0.0022160118,-0.037239257,0.020319559,0.04993364,0.01191745,-0.044712115,0.054143902,-0.054628596,-0.03655161,-0.07306253,0.0069269403,-0.070231974,-0.012068549,0.04932247,0.04367688,-0.009489849,0.05752054,-0.021319054,0.022534117,0.05456283,0.06279514,-0.13887404,-0.040086795,0.027227936,-0.014392825,0.021183467,-0.08110029,-0.04902897,0.00016737731,0.044602863,0.017631069,-0.01139889,0.044846606,-0.013426497,-0.011571407,0.024390316,-0.07287568,0.04034184,0.0317494,0.05134858,0.06046374,0.025948819,0.104335696,-0.0057304194,0.04387774,0.07248735,-0.0001386496,-0.00087791693,0.10205851,0.024686622,-0.022022137,-0.04101336,0.062053382,-0.011734872,-0.012423168,0.01764296,0.013188136,0.04212867,-0.09074843,0.061253253,-0.048509296,0.029782034,-0.004033661,-0.027589403,0.048125643,-0.043049317,0.010257906,-0.021532375,-0.0012470357,0.040150914,-4.6400007e-08,0.024019511,-0.007145825,0.07844454,-0.040897142,0.039724592,0.040972833,0.011850685,-0.014166324,0.014413335,0.027900063,-0.0062701665,0.07256844,0.05566832,0.005368832,0.02681883,0.003133507,-0.021270514,-0.003308785,-0.046446208,0.010895012,-0.0011228895,0.003973411,-0.09388456,0.032757293,0.02807201,-0.029322196,0.01620065,-0.03935465,0.008024709,-0.050120622,-0.04135051,0.0017775137,0.05281555,-0.04862766,-0.15994905,0.02378644,-0.0025389553,0.010999946,-0.1293415,0.03811441,-0.0010437692,-0.06253957,-0.035628777,0.031769656,0.019546568,-0.019393886,0.04548603,0.0022257662,-0.030826503,0.019840749,0.053314134,-0.038412284,0.02143368,-0.06252855,-0.12043372,-0.010221688,0.005822503,-0.005706068,-0.042809792,-0.050796088,0.06605128,-0.043298844,0.1304281,0.013873008 +1.3.99.35,"The enzyme, together with EC 1.1.1.396, bacteriochlorophyllide a dehydrogenase, and EC 4.2.1.165, chlorophyllide a hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. This enzyme catalyses trans-reduction of the B-ring; the product has the (7R,8R)-configuration. The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of nitrogenase (EC 1.18.6.1), which catalyses an ATP-driven reduction. ",384,0.99999994,-0.0466149,0.025961021,-0.06517609,-0.04809253,0.07735217,0.040467117,-0.04672617,-0.0022791598,0.062431164,-0.08730114,-0.034966383,-0.0522578,-0.0065762387,0.04735337,-0.03947252,0.034965135,-0.13972425,0.013038467,-0.03645231,-0.06441678,0.025686081,0.014240735,-0.023435272,-0.009265322,-0.023115907,0.04264816,0.05494859,-0.020648697,-0.028198099,-0.09861438,-0.041467134,-0.010228954,0.045994557,-0.048210483,0.026103463,0.08970033,0.018483113,-0.066535555,0.06417012,0.028195204,-0.003540918,0.048936225,-0.010210915,-0.053788003,-0.034125563,0.043132648,0.026191678,0.026915949,0.017543988,-0.06398045,-0.018230926,0.00033220826,-0.03739512,0.060734253,0.019913182,0.008315438,-0.07470568,-0.061480258,-0.00042634478,0.037891325,0.04792052,-0.011806045,0.022167915,0.02922245,0.037789006,-0.024864368,0.046687413,-0.06663329,0.031738706,-0.056387976,-0.06740512,-0.039839618,-0.014314527,0.03538289,0.00314947,0.0042253598,0.044029657,0.012183966,0.013994685,-0.023811596,0.016919313,-0.0058257296,-0.014768654,0.046549797,0.044903226,-0.048940156,-0.024209443,-0.024635948,0.05038639,-0.0061775967,0.00032726547,-0.011448453,0.015103725,-0.046748325,-0.07803213,0.104590796,-0.040372428,-0.03770482,0.045717154,0.0038474677,-0.016999513,0.04176177,-0.028201798,-0.08384232,0.0356415,0.028053649,-0.0020663044,0.16045937,0.025180459,0.023190554,0.033328008,0.018994201,0.06422495,0.034892436,-0.013356048,0.06491367,0.031120239,-0.015886543,-0.06484605,0.02642187,0.0245043,0.0017548765,-0.0015906912,0.042474262,-0.0648571,0.09770633,-0.17086507,2.422137e-33,0.081159174,-0.016496396,0.029064113,-0.023085196,0.035803266,-0.034636267,-0.078651786,0.03252988,-0.051622424,-0.052862234,-0.010892391,-0.07317961,0.082809314,-0.08554405,-0.025885323,-0.08464251,0.019345308,0.037070617,0.00476116,0.017348018,0.006114116,0.10449269,-0.06534365,0.06520561,0.042179342,0.09532843,0.015252289,-0.036233786,0.11186205,-0.016125014,-0.041855264,-0.061710257,-0.11085837,0.007970378,0.06759506,-0.05116517,-0.034278825,-0.022475809,0.016447257,0.07676227,-0.08055166,0.034724824,-0.07057106,-0.034363054,0.06365794,-0.061587594,-0.013789507,0.06356685,0.06307058,0.07048606,-0.007141507,-0.033987314,0.09061765,-0.055312432,-0.06068657,0.013847256,-0.0030385915,0.009813407,0.009631943,0.07245974,0.018202947,0.039031886,-0.055273376,-0.0018337594,0.0051164124,-0.04262895,-0.03614285,-0.04391059,-0.00022002702,0.044468805,-0.11114765,0.026071113,0.07197737,0.03177125,0.09171169,-0.0506515,-0.027265484,-0.07696678,0.027195139,0.016576992,0.00043632332,0.07325078,0.1339765,-0.07069557,-0.053757865,-0.03959072,-0.02464371,-0.090650074,0.0041932873,-0.041673616,0.051876012,-0.048424702,-0.061767727,0.00705058,-0.008842833,-2.6520993e-33,0.1106694,-0.1066002,0.068650976,-0.0854917,-0.07090999,0.027031332,0.0042882324,-0.082904086,-0.021140866,0.008477276,0.07951063,0.0045628604,-0.00037231992,-0.051889263,0.011614876,-0.013093261,0.074263394,0.07151492,-0.011140772,0.018281687,0.007141251,0.09419212,0.047107175,0.002490943,0.019753678,0.001419683,0.004996887,0.052962713,0.12303949,0.0030885644,-0.040253114,-0.05320288,-0.02683788,0.019482916,-0.011232341,0.026468785,-0.04180174,-0.0059124273,0.033434536,0.014735539,0.013947285,-0.020161673,-0.03848495,0.039677653,0.024522878,0.051797085,-0.06162912,0.04111665,0.020781135,-0.051268697,-0.0020696153,0.011951486,-0.046017073,0.013413396,-0.018232765,-0.014134486,0.11265863,0.00032059065,-0.011850623,0.005804758,0.014911547,-0.08346305,0.09953981,0.02028463,0.021427104,0.09597251,-0.037512355,0.07632411,0.03528156,-0.040235776,0.0030827087,0.033372846,0.06455704,0.019263733,0.009742023,-0.030443465,-0.0019282144,-0.10336056,-0.046358883,-0.043379553,-0.067198105,0.037571587,-0.016718417,-0.09300577,-0.011106743,-0.034566954,0.0049276105,0.053265054,0.008797851,0.028210497,-0.00441497,-0.014635598,0.010905883,0.07070737,0.02446749,-4.3660936e-08,0.02505707,-0.036077082,-0.01767328,-0.035389908,0.014434818,0.07881729,-0.06344371,-0.027473228,0.07337808,-0.07894239,0.008191989,0.04157109,0.03379009,0.003611619,0.015597663,0.019990047,-0.021799445,-0.04921225,-0.0030030757,0.0022001562,-0.05540023,-0.027297292,-0.13142969,0.07648861,0.025937911,-0.04826264,0.0016022765,0.047161188,0.007853064,-0.07537861,-0.034569964,0.015175724,-0.025558326,0.021117859,-0.008556761,-0.011005409,-0.036591277,0.017823257,-0.035275664,0.08922587,0.082761765,-0.03662818,-0.08798957,0.06607832,0.05291797,0.037382025,-0.028686486,0.022425601,0.0019300389,0.058907323,0.0750414,-0.024320275,0.03946319,-0.025339287,-0.12353264,0.008279584,-0.03325551,-0.103774056,-0.03110803,-0.029555794,0.012868124,-0.043007776,0.17516984,0.009541253 +1.5.98.1,"Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus.",384,1.0,-0.056675483,0.007187765,-0.107432984,0.03400711,0.0402146,0.02315767,-0.098498,0.12448278,-0.019878894,0.0005758712,-0.018756848,-0.10542138,-0.10557406,0.016386762,-0.00936895,0.03415811,-0.03087688,-0.051832765,-0.020477962,-0.06721353,0.0032109376,0.06552481,-0.034665797,0.017887732,-0.017564174,-0.004681147,0.008817018,0.0059609017,0.03129338,0.021432634,-0.02493502,-0.014838502,0.07427198,-0.017048314,0.02478477,0.062474515,0.011260043,-0.07266212,0.10394256,0.04379922,0.0122556705,0.03363899,0.027037019,-0.018658102,-0.024118872,0.004168751,-0.02823117,0.031227037,0.044002585,-0.06751911,-0.002802959,0.027028063,-0.0639629,0.023368029,0.09119146,-0.005871966,0.013177141,-0.063493416,0.021785086,-0.038384527,0.08416958,-0.036684237,0.031047028,-0.009412065,0.039326,-0.024884036,0.06686697,-0.10050175,0.099217616,-0.012844646,-0.064460225,0.01764606,-0.023513556,-0.011560753,-0.045146637,-0.03670507,-0.038152825,-0.04998965,0.0766038,-0.021502035,0.075755276,0.0087448675,0.05444702,0.010865736,0.038041484,-0.05701515,-0.035180748,-0.014125965,0.055869855,-0.04095585,-0.046243098,-0.018949322,-0.03696314,0.025277598,-0.1836688,0.00479015,0.106616236,0.0038845984,0.027244398,0.042592667,-0.036677666,0.02182436,-0.10948538,-0.04369083,-0.07754568,-0.009398692,0.0775668,0.09671556,0.04301322,0.039894115,-0.023655232,0.0013234931,0.04763341,-0.009536697,0.0091076195,0.004949324,-0.0031125469,-0.05723965,0.05901242,0.07719078,0.049736314,-0.016277093,0.039307106,0.07713407,-0.011273879,-0.008694968,-0.09393462,4.1308642e-33,0.06903333,0.06401324,0.026848719,0.036190998,0.060705688,-0.03148575,-0.063802935,0.032986954,-0.029709417,0.013173264,-0.05287863,-0.068330884,0.04470702,0.022916332,-0.07077204,-0.0752324,-0.06375232,-0.02833108,-0.008168165,0.028772725,-0.010828298,0.073910266,-0.0030696427,0.0422838,0.060530894,0.02642683,-0.012743105,0.043597296,0.055903498,-0.007907976,-0.0062464895,-0.06342603,-0.14608881,0.0124169085,0.029006023,-0.03640506,-0.07837827,-0.046276446,-0.0902789,0.05720668,0.036167588,0.0015848358,-0.027292814,-0.041386325,0.080284484,0.0027622825,-0.025055638,0.07809012,0.056530938,0.04982035,-0.030049572,0.014867885,-0.03208388,-0.032779373,-0.057517525,-0.059402782,-0.006735967,-0.027120737,0.03228071,0.059067246,0.025613079,0.005133013,-0.027344797,0.051869288,-0.03225619,0.021519223,-0.015558353,-0.060943022,0.07880525,0.058493398,-0.03451411,0.0287736,0.030521331,0.09642668,0.05104328,-0.05475392,0.0018998609,-0.032321952,0.040213246,0.0019380215,-0.007979218,-0.020136215,0.022522077,0.0033603965,-0.09005301,-0.029818883,-0.058933493,-0.061647374,0.03998122,0.03786439,-0.02622279,-0.034325067,0.024454491,0.009995121,0.025917497,-4.054367e-33,0.03272929,-0.037385307,-0.01714242,-0.09887896,-0.045826286,0.065134004,-0.04393862,-0.03946283,0.026618648,-0.032438073,0.19069283,-0.036771502,0.054991577,0.014699223,0.052275527,0.06259786,-0.029737566,0.029548703,-0.028018657,-0.05365653,-0.012148709,0.0045791273,-0.008671211,-0.011018662,0.056400273,0.015954746,0.001177948,-0.0017074884,0.050114103,0.095158964,-0.031635523,-0.020306008,-0.04412635,0.036837373,-0.09110724,0.049879435,-0.049545936,-0.007554452,-0.028962547,-0.015872672,0.00026296725,0.043032587,-0.018753877,0.03611762,-0.015520515,0.009503768,-0.031448685,-0.06781144,0.055526324,-0.000116399075,0.015917474,-0.08158849,-0.09425671,-0.06007088,-0.076322876,0.092183955,0.05150425,0.0050468305,0.061394986,-0.004211144,0.036482405,-0.018133687,0.057632048,0.08199923,0.05382312,0.07072516,-0.041155852,0.051725335,0.096477814,0.02945665,0.068913944,0.01991683,0.054546133,0.09298575,0.020984087,-0.045601442,-0.03333185,-0.019476896,-0.07479357,0.02107564,0.015710773,-0.04584548,0.047349267,-0.009133872,-0.0754312,-0.10369794,-0.003562154,0.021471022,-0.015686741,0.06523794,-0.03298322,-0.0065477733,-0.030020796,0.019697646,0.045772687,-3.7122888e-08,0.041603472,-0.030411223,-0.02587017,-0.039057262,0.0100706685,0.02848863,0.023072839,-0.09220785,0.005332848,0.0010485179,-0.02979107,0.068821006,0.044464953,0.0407786,0.015188467,-0.0036703534,-0.029618222,-0.02650495,-0.027803637,0.028088495,-0.06670437,-0.009526554,-0.04744602,-0.014422279,-0.011040092,-0.053737246,0.009205963,0.15037553,0.04487627,-0.048911013,0.0020289873,0.09274815,-0.023376899,-0.038106024,-0.08778133,0.07463219,-0.0020576555,-0.023483027,-0.11493668,0.044163316,-0.0091046505,-0.006821235,-0.079561904,0.010833483,0.11819067,-0.037326824,-0.0052084327,0.013102181,-0.0037390694,-0.037044145,0.06666633,0.0039979895,0.0041446895,0.022611491,-0.061894223,-0.02023657,-0.075678736,0.0033458879,-0.029437058,-0.05942387,0.008982003,0.0031708407,0.17229857,-0.07798516 +1.5.98.2,Catalyses an intermediate step in methanogenesis from CO2 and H2 in methanogenic archaea.,384,1.0,-0.04083024,-0.014810478,-0.038822502,0.018510692,0.06977898,-0.025024135,-0.084126316,-0.021410061,0.0016629532,0.0005074492,-0.052588005,-0.09734422,-0.04915339,-0.045125604,0.0021846595,0.008579933,-0.048721425,-0.021776997,0.056835614,-0.009670534,0.07300032,0.07736591,-0.04971632,-0.016707625,-0.0364498,0.043382652,0.036534294,-0.024517925,0.020053215,0.0035416458,0.046632644,-0.067502,0.06202202,-0.022468958,0.045790132,0.06922924,0.06876819,-0.030835053,0.0507297,-0.026381616,-0.005658304,0.016107991,0.09888294,0.012212314,-0.006658954,0.0373357,0.08738035,-0.0122191245,0.0015860304,-0.112888895,-0.06493869,-0.040916312,-0.059313856,-0.024945192,0.04268121,0.112636544,-0.005624586,-0.019963587,0.080045834,-0.072182745,0.043919,0.012675288,0.02304675,-0.019008981,-0.0020802312,-0.06343438,0.07329077,-0.0415099,0.13181604,0.019812206,-0.03503771,0.065950304,-0.039159317,-0.10918293,-0.030873038,-0.012730002,-0.012502352,-0.051729664,0.06414537,-0.015490468,-0.031425152,0.040280744,0.04785001,-0.033143472,0.009974169,-0.040094305,0.016210135,-0.005399336,0.039273914,-0.054298535,-0.038867615,-0.008274627,0.013026687,-0.0051734615,-0.10388341,-0.015495034,0.15968429,0.05025599,0.03688918,0.0115022585,-0.0066760005,0.03962941,-0.071281,-0.04890215,-0.040088978,-0.06948703,0.052667364,0.16327913,0.041299343,0.10242963,0.062132,-0.036700882,0.0676147,0.020093985,0.008231971,0.07819995,-0.0040215743,-0.060417254,-0.063025706,-0.0017742922,-0.01188,0.010569692,0.046651285,-0.010722752,-0.07811607,-0.0061183823,-0.061819687,5.965588e-34,0.08297874,-0.010502665,-0.040637,0.013462202,-0.0012292789,-0.024344241,-0.10715752,-0.040979587,0.027891746,0.023635605,-0.039180383,-0.026765173,0.06632092,-0.018747106,-0.06577921,-0.037916195,-0.030957414,-0.031724177,0.010842629,0.04752303,-0.09087298,-0.016142014,0.008952065,0.0064678434,0.018036984,-0.013356441,0.049066808,-0.057933163,0.053917307,0.014246324,0.017918529,-0.075019695,-0.089292996,0.027804224,0.06772366,0.022806564,-0.095755234,0.019809237,-0.07007931,-0.028881002,0.027877577,0.047517568,0.0032392864,-0.075030655,0.019364092,0.034530647,0.022105461,0.12198364,-0.0005809628,-0.003365772,-0.056844667,-0.002465676,0.050270177,0.00945198,-0.08088908,-0.040894724,0.038745135,-0.05127231,0.045027576,0.05254187,-0.043530356,0.06027673,0.020375365,0.106885195,-0.057680123,0.050181255,-0.0038171776,0.016843721,0.11533311,0.102683224,-0.007187797,0.02739471,0.026224714,0.058678366,-0.017345749,-0.057325877,0.04712945,-0.093812995,0.050416127,0.050710063,0.054561503,-0.055958394,0.049446933,-0.058136422,0.011683787,0.0056200447,-0.09985163,-0.008512574,-0.009099636,0.077268586,-0.028823083,-0.03179101,0.04714853,-0.015991567,-0.02437232,-2.2871426e-33,0.05084417,-0.04199112,-0.028623419,-0.13283654,-0.08800137,0.054270066,-0.0408493,-0.09597616,0.0140399365,-0.04876408,0.07335975,-0.0036179188,0.04693579,-0.03206709,0.02054982,-0.098342285,-0.0074207475,0.066403076,0.076873586,0.023497388,0.13541505,-0.024569705,-0.10319701,-0.07197889,0.05374,-0.008860123,-0.0054695923,0.043703154,0.009366578,0.029365322,0.046670068,-0.0072113615,-0.05113797,-0.029776996,-0.112479284,-0.0020383762,-0.058065724,-0.023913065,0.006708557,-0.0001247485,0.034575682,0.033216868,0.018402932,0.04117837,0.04103488,0.0031526398,-0.04452126,0.019519538,-0.030679772,-0.033622127,0.007680547,-0.10023259,-0.067629546,-0.117092445,-0.03183459,0.06838871,-0.0011075847,0.055323806,0.032848865,-0.016841225,-0.014480455,-0.06687318,0.027172878,-0.008660245,0.009062702,-0.026480798,0.00058692036,0.03258976,0.0027995268,0.008499249,-0.029795727,0.050964978,0.018575164,0.03908769,0.020098384,-0.041690763,-0.036545146,-0.013525432,0.05239901,-0.056809112,0.0004945962,0.024791718,0.09580566,-0.04512439,0.038582027,-0.066891626,0.042623468,-0.016071692,-0.062611304,0.046677273,-0.06588349,0.0018133875,0.020413991,-0.020948807,0.015322876,-1.9952054e-08,-0.0042314455,0.0216207,0.067683235,0.036258794,-0.02233842,0.13580605,0.048565228,0.02538775,0.029559596,-0.042603128,0.0043301648,0.017554589,0.064742744,-0.037355047,-0.029490357,0.065511525,-0.018280422,-0.06354827,-0.058242645,-0.026740054,0.024845412,-0.05817475,-0.011501642,0.03958276,-0.0024185288,-0.053398747,0.033622637,0.07319159,-0.057499748,-0.11332125,-0.0182346,-0.0028899205,0.017933533,-0.038903065,-0.025059616,-0.03139244,-0.03096997,-0.024725925,0.0019355386,-0.07293047,-0.006212076,0.072253816,-0.04598572,0.017248277,0.018776607,0.010172483,-0.046514057,0.029804131,-0.04292694,0.039477058,0.066436164,-0.019696975,0.09454337,-0.040165633,-0.012377856,-0.0077618137,0.0065164305,0.006633148,-0.0694739,0.04036306,0.12183069,0.024970202,0.03191218,-0.03711644 +1.6.3.5,"Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta-NAD(P)+. These isomeric forms, generated by nonspecific reduction of beta-NAD(P)+ or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.",384,0.99999994,-0.08200034,-0.037226282,-0.036160287,-0.0020262902,0.021524265,0.028093485,-0.0483657,0.03396299,0.03969079,0.018817795,-0.07489524,0.073556446,-0.101835646,0.002988437,-0.11441511,-0.043242287,-0.073813036,-0.0065210206,0.0034620655,-0.024469608,0.029637018,0.0009950192,-0.015913002,-0.044368077,0.0740403,-0.0065446137,0.04824308,0.0014703153,-0.040562224,-0.00074003416,-0.033549715,0.021327002,-0.018617542,-0.022871066,-0.049120776,0.1159442,-0.019345956,-0.028576756,-0.072107695,0.0015337034,0.078668974,-0.09733575,-0.07271069,0.02310481,0.019691085,-0.0031721871,-0.07114679,0.0618579,0.019882586,0.06951529,-0.08711702,-0.029283859,-0.05111184,0.10232373,-0.03338092,-0.010832767,0.034586415,-0.0141260605,-0.024035567,-0.06927343,-0.0762659,-0.014590393,0.03734308,0.021955144,0.07367371,-0.009900509,-0.0071634557,-0.044338036,0.025800463,-0.06997986,0.014895197,-0.01398505,-0.05366698,-0.010737083,-0.057852995,-0.0087247705,-0.13358076,-0.045656495,0.004929681,0.023197431,0.11403045,0.01378663,0.04703384,0.05049924,0.06747368,0.008322424,-0.018333592,-0.01589378,-0.04455121,0.062353108,-0.05758068,-0.018086655,0.032589752,0.022581585,-0.089861706,0.013560237,0.024734445,-0.0041152653,-0.06749311,-0.044451594,-0.047331046,0.07915516,-0.017158354,-0.030708421,-0.04708128,-0.013763217,-0.0004890651,0.04178723,-0.03707289,0.004797143,-0.026175845,0.026755394,0.039215397,-0.002067557,-0.0040247096,0.07813847,0.023469735,-0.024746593,-0.09693686,-0.024010343,-0.03785283,0.03586624,0.015591274,0.08041843,0.047258127,0.027526487,-0.103906095,7.856793e-34,0.100770004,0.04924966,0.00029545612,0.025985723,0.0040492103,0.060153857,-0.021919258,0.033618536,0.032263946,-0.04532938,-0.036781482,-0.050223187,0.013324408,-0.024802845,0.042231873,0.036970627,0.015159491,0.015046384,0.15622324,-0.095340386,0.07546723,0.061562058,-0.004722666,0.00081166154,0.042292334,-0.008977042,-0.056457337,0.091558225,0.019282209,0.020079048,0.039267857,-0.0960644,-0.02563812,-0.034161273,0.00055194733,-0.05902986,-0.08445745,-0.055007916,-0.04546689,0.028455378,-0.024026668,-0.05001729,0.0011718001,-0.07081636,0.074690774,-0.07662358,-0.06282922,0.026040519,-0.033199128,0.11570594,0.013656542,-0.05018969,0.12621342,-0.006664011,-0.0757867,0.0009509574,-0.05496572,-0.11161597,-0.028723361,0.07441362,0.0095080845,0.07584453,0.00028516614,0.05904902,-0.08583475,-0.05356801,-0.068348065,-0.06969635,0.011578482,0.07723799,-0.054501478,-0.06757068,0.04765335,-0.014337513,0.030284384,-0.011497737,0.0033571047,-0.044110417,0.039387103,-0.026249133,0.03462234,0.006782348,-0.015421748,0.080173,0.01687102,-0.005785028,0.027671834,-0.05878133,0.012536808,-0.0031439897,0.014600604,-0.04979763,-0.0987435,0.011779541,0.06445005,-2.497026e-33,0.09714311,-0.09675264,0.025158754,-0.030483091,0.0065741716,0.07216112,0.054409944,-0.071698576,0.102774985,-0.009811264,0.012552095,-0.012524929,-0.02365772,-0.07817698,0.053028986,-0.04339738,-0.00888382,-0.027628507,-0.008456905,-0.0026209494,0.00035504487,0.061380118,0.03140108,0.05378908,0.026291952,-0.04369277,0.022234807,0.008233829,0.037723195,0.062403172,-0.04381663,0.08124786,-0.041657984,-0.053296313,-0.03222919,-0.0017723948,-0.042013712,0.047999106,0.025203051,0.03844371,0.03945167,-0.017785149,-0.012780368,0.020932958,0.039779603,0.03870938,0.018757941,-0.002726445,0.03599031,-0.048359804,0.05992761,-0.0011920555,-0.040678594,0.11192907,0.081867516,-0.014342003,0.003733313,0.06693184,-0.025007436,0.029573193,0.04132863,-0.02336116,0.061181694,-0.015328837,0.0079101585,-0.010992651,0.067444906,0.08156862,0.0027196566,0.010314567,0.07764186,-0.014289075,0.055245906,0.12387477,0.016088657,-0.10885633,-0.056681484,0.029890591,-0.0067787883,-0.010287387,-0.012061281,0.011193168,-0.03721036,-0.038845357,-0.049716376,-0.09461769,0.045646295,0.051415093,-0.0031474289,0.0124866525,-0.03735153,0.034299225,-0.06734802,0.020791452,0.04602324,-4.393266e-08,0.047961485,0.012227442,0.062073592,-0.015006607,0.020531835,-0.038278878,0.05485134,0.031715084,0.014783106,0.0078015984,0.0034411326,0.07521876,0.07032549,-0.015426916,0.06362891,0.031253997,-0.024645146,0.021829737,-0.037050545,-0.04672769,-0.0015432293,-0.016880317,-0.1185013,0.06855432,0.030926596,-0.0823414,0.006683857,-0.06834072,0.015348074,-0.0088951,0.014809414,0.017749127,0.0935259,-0.030873131,-0.08887119,0.052485406,0.06108791,-0.0074958075,-0.028193906,-0.026551254,-0.08207082,-0.02551414,-0.03059474,-0.010261781,-0.009860301,0.037257914,0.08303416,0.020038351,-0.031161662,0.017193075,0.030102756,0.020568604,-0.016213996,-0.08887606,-0.0474013,0.07359089,-0.030424237,-0.12416148,-0.015328694,-0.08509437,0.12169333,0.022030128,0.10455649,-0.050637357 +1.10.3.14,"This terminal oxidase enzyme is unable to pump protons but generates a proton motive force by transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water. The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) is 1. The bd-I oxidase from the bacterium Escherichia coli is the predominant respiratory oxygen reductase that functions under microaerophilic conditions in that organism. cf. EC 1.10.3.10, ubiquinol oxidase (H+-transporting).",384,0.99999994,-0.052875362,0.016528508,-0.12741193,0.06753472,0.06497377,-0.0043808995,0.036702503,0.032511327,0.00063978403,-0.07048582,-0.00259642,-0.019223075,-0.00223879,0.05329148,-0.06711853,0.03797059,-0.0288117,-0.00849263,-0.08974833,-0.057945233,0.09280293,0.027238915,0.05084292,-0.07408417,-0.009128684,-0.069038995,0.06992025,-0.031031333,-0.022903712,-0.06589561,0.045492478,-0.09584008,0.051327243,-0.13506725,0.039190426,0.08722623,0.012983345,-0.08113742,0.009883458,-0.0029115865,0.027643971,-0.02509073,-0.00077208015,0.06724615,-0.012078192,0.023031706,-0.034343034,0.034385517,0.05324643,-0.030383987,-0.0016950404,-0.022500454,-0.06971493,0.040044565,-0.018671848,0.039825145,-0.03984135,-0.023196645,-0.00017988194,-0.05778366,0.018261364,0.03863244,0.093993396,0.011187937,-0.009521797,-0.057533804,0.025658326,-0.042514004,-0.02472087,-0.03669667,-0.03650791,-0.074685775,-0.06795718,-0.057945985,-0.051015347,-0.028519413,0.011912799,-0.05296126,0.021985209,0.006599444,0.04859636,-0.059363432,-0.0027862135,0.07051461,0.04403726,0.001615938,0.014044848,-0.11282578,-0.0007561739,0.04855505,-0.04819274,-0.027715463,-0.0027266957,0.0056191906,-0.08539982,-0.029233005,0.06649247,0.09556689,-0.026109425,-0.032994933,-0.034015253,0.13703851,-0.01849968,-0.05892353,-0.04043926,-0.033083607,0.04381997,0.12450846,0.0729925,0.007797678,0.057846267,-0.009900625,-0.014522822,0.016466672,0.0425161,0.08628022,0.010942153,-0.016843112,-0.08554698,0.018001188,0.008524827,-0.0067783957,0.0047114864,-0.016443266,-0.036524344,-0.06723839,-0.09236163,2.6426028e-33,0.056003492,-0.043461487,-0.008344684,-0.020610934,-0.039208807,-0.036928736,-0.101546854,-0.011852242,-0.0036702193,-0.0016781774,-0.12660475,-0.042114984,0.049261767,0.027455123,-0.0047312514,-0.070541985,-0.040784944,-0.019586409,0.048592135,0.06534212,0.026177585,0.0106406165,0.006415527,-0.07829064,0.09978907,-0.03460751,-0.008956538,0.028002156,0.06619083,-0.0030729624,0.056011885,-0.06320578,-0.12668014,0.0012510766,-0.032109343,0.017941954,-0.0704109,0.005286203,0.0006575093,0.035329264,-0.033876687,0.05255309,-0.0047992296,-0.047294248,0.11320399,-0.039703492,-0.022175986,0.07780399,0.046184525,0.051745076,-0.023543168,-0.013032155,0.12585169,-0.014884206,-0.005196976,-0.07178187,0.013252609,0.07042658,0.020970266,0.1019656,-0.0014428957,0.11077102,-0.06586196,0.07064583,0.01103976,0.061762895,-0.010472597,-0.025589595,0.0015539409,0.07120752,-0.045631435,-0.0063512786,0.030846756,-0.039865494,0.015935358,-0.026688455,-0.04354485,0.002501768,0.04706323,-0.026472481,0.01014898,-0.0053761518,0.00374588,-0.029958261,0.037202783,0.0005421136,-0.03720302,0.0010788755,-0.03190698,0.022209788,0.10431348,-0.05358731,-0.020940555,-0.08642682,0.0321578,-3.4123437e-33,0.10115019,-0.038568813,-0.011044943,-0.09790402,0.018883536,0.07882156,0.008591046,0.03652667,-0.010663661,-0.0031493679,0.0030699573,0.04890165,0.009920534,-0.022007687,0.04947363,-0.017372567,-0.0608828,0.0015234502,0.04216448,-0.010711878,0.02109502,0.10347988,0.0327705,-0.015617951,0.02086341,0.024834476,-0.07577995,-0.0078158695,0.0711397,-0.003476046,-0.044412617,0.017498624,-0.027542418,0.0003441411,-0.08991919,0.07388796,-0.10063376,0.046634715,0.09992664,0.033953745,-0.026178205,-0.030749347,0.0048380806,0.027660975,0.007890507,0.113230236,-0.13896129,-0.01877972,0.010171138,-0.034623336,0.041400056,0.022771321,-0.086475104,-0.02866891,0.026498578,0.01591767,0.012240351,0.008415565,-0.011598546,-0.06293297,-0.005395858,-0.0043420647,0.07167389,0.0011344906,-0.04558653,0.057805553,0.07500663,0.04310978,0.019362913,-0.030698676,0.039611056,0.0040840013,0.006221642,0.022860011,-0.033204135,-0.044072565,-0.028253289,0.0032935461,0.011278245,0.033779092,0.015556535,0.040094044,0.00995508,-0.092161365,0.036174156,-0.10840907,-0.0042621545,0.020411696,0.03282138,0.055461086,0.037516728,0.002985175,-0.016179254,0.04708797,0.04090769,-4.1413653e-08,0.03190292,-0.05600482,0.08494795,-0.03701535,0.030447418,0.031133572,-0.0036678226,0.03279512,0.030703695,-0.024219546,0.002607435,0.08337648,0.018832924,0.009994385,0.10286804,0.050400775,-0.009828519,-0.012476969,-0.0026618596,-0.060664285,-0.023588052,-0.018260283,-0.15719669,0.062203266,0.04550354,-0.056519035,0.022829168,-0.031632327,-0.03536225,-0.08036643,0.014822785,0.049397986,-0.035182405,0.026451454,-0.07669108,0.009131642,-0.039868113,-0.007598686,-0.044747118,0.010261257,-0.050242763,-0.028185826,-0.034259442,0.03525654,0.037591968,0.044025015,-0.018526325,0.02386962,-0.03798419,-0.011161215,0.033774663,-0.098877095,0.051069215,-0.06882208,-0.114843965,0.13143903,-0.04013983,-0.06425094,-0.012371747,-0.038962673,0.05347776,0.046455037,0.12824444,-0.012774383 +1.14.13.185,A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin. ,384,1.0,-0.08653374,0.03393119,-0.06225093,-0.09295905,-0.019405108,0.029517207,-0.013937036,0.13105898,0.038986146,-0.0121177165,-0.0066913282,0.022207323,0.09417869,0.10258937,-0.039246056,0.0018041546,-0.025504358,0.022946741,0.009367599,-0.01848361,0.00065447536,0.048317198,0.05021983,0.030297767,0.0255271,-0.02351571,0.015432372,0.06960666,-0.067558505,-0.035704404,0.071355514,0.04066633,-0.01661417,-0.021345831,0.067442976,0.07052528,-0.114265285,-0.01629276,0.09438795,-0.0023721692,0.027206097,-0.008925526,-0.009606088,0.07222894,0.0132447835,0.0020273498,-0.07620055,0.048119266,0.039546188,-0.021955654,-0.025612816,-0.016518127,-0.076706834,0.11682453,0.07452215,0.043592807,-0.072358504,-0.08610541,-0.021333966,-0.033611737,0.013108803,-0.0013720097,-0.011898102,0.041911907,-0.0552058,-0.055972055,0.019767819,-0.04716039,0.013297572,0.019049406,-0.050121162,-0.0747769,-0.0075869183,0.029252023,-0.061120395,0.0003235094,-0.052072342,0.012798186,-0.06368776,-0.0367898,0.036515296,0.024467265,0.007749344,0.10044357,0.072473414,-0.0500806,0.050576985,-0.0050755898,-0.04140427,0.033385996,0.0159023,0.015993344,-0.0005128153,-0.033505682,-0.1408437,-0.05460433,0.006537386,0.018219016,0.0045913355,-0.008023248,0.03796823,0.06537204,0.0024768908,-0.07269379,-0.04168677,-0.02648971,0.031550713,0.06257598,0.018637158,-0.033350524,-0.04793302,-0.034656193,-0.007091099,-0.058051378,-0.025725504,0.12239152,0.10591085,-0.01333964,-0.011089315,-0.055121753,-0.03843536,-0.03627271,-0.016287273,-0.043361325,-0.059007958,0.050263844,-0.08414215,5.5757205e-33,0.07217321,0.023726141,-0.034044456,0.05064718,0.04090337,0.02211456,-0.084204145,-0.0058929897,-0.042253535,-0.035675813,-0.072799586,-0.011187566,0.020139415,0.06283962,-0.04539458,-0.004238104,-0.055185355,0.04797321,0.013099208,0.0068354495,-0.0045834165,0.028430436,-0.024532566,-0.017309034,0.042278517,0.13132344,-0.09645249,0.029296275,0.0072904993,-0.00039143598,-0.064280644,-0.030847896,-0.057552807,-0.010251486,0.03618263,-0.036663808,-0.017160216,-0.04872253,0.089125164,0.010216279,-0.057441596,-0.050022874,0.012342577,-0.07222171,0.07918915,0.007579311,-0.09105577,0.06122084,-0.02064271,0.048502937,0.103555635,-0.064565115,0.056601882,-0.013271789,-0.08091331,0.040684734,0.003865356,0.040066965,-0.029581193,0.06379803,0.11507549,0.040702846,-0.0071903775,-0.0007059949,0.08493038,0.039543997,-0.044787392,-0.025161995,-0.035794765,0.08844674,-0.086934805,0.044276442,0.09414471,0.014783351,0.07194038,0.028868096,-0.047390167,0.019114403,0.08457265,0.04541881,-0.0188848,-0.005607073,-0.051092412,-0.015778307,0.00796271,-0.016884403,0.039317004,-0.05649573,-0.0054519586,0.009716604,-0.014515804,-0.14253287,-0.011592851,-0.0011618931,-0.028456956,-7.09958e-33,0.07599728,-0.033214167,0.027442247,-0.03976615,-0.01654925,0.06467825,0.039162774,-0.0603639,0.014019667,0.025362356,0.09902986,-0.01743062,-0.07267072,-0.018663844,-0.03405435,-0.058983747,-0.026902556,0.026500486,-0.058095362,0.022384768,0.02271318,0.021972135,-0.019689409,0.014392303,0.008488275,0.050497208,0.016677,0.018617775,0.090179525,0.06629695,-0.059342094,-0.0032516515,-0.077201925,-0.07077338,-0.0708167,0.13296808,-0.03099494,0.026354743,-0.0063657444,-0.038841072,0.006405884,0.03627036,-0.023303377,0.03963352,0.02495804,0.05323987,-0.046250366,-0.018226406,0.027151464,-0.030497197,0.0383084,0.04053174,0.0367347,0.08284451,-0.080549,0.03568611,-0.007899516,-0.0059771417,0.00562284,-0.033246946,-0.07677167,-0.02138647,-0.019837832,0.026154527,-0.0368402,0.05447634,-0.06884862,0.030959273,0.05576674,-0.028085353,0.0037992646,0.0314056,0.042126883,0.0023467878,-0.013100262,0.03473976,-0.015737483,-0.07191604,0.020019094,0.059352316,-0.017007353,-0.006891061,-0.0513551,0.01123756,-0.044780307,-0.03852893,-0.034687296,-0.0016230734,0.034297217,-0.0683597,0.010844547,0.081931055,-0.03649083,0.06162632,-0.010759511,-4.3022563e-08,0.036007445,-0.041070998,0.053820048,-0.02842797,0.071266755,-0.0041537676,-0.036101636,-0.04200604,0.038424212,-0.038432423,0.02007414,0.10305934,-0.057333425,-0.06367992,-0.018971816,0.062032383,-0.0069817225,0.022957625,0.027337888,-8.115506e-06,-0.07460175,-0.001597052,-0.05818012,0.050712083,0.04254594,-0.061728522,0.013602708,-0.006544633,0.010832091,0.008644813,0.074051864,0.032398976,-0.083080545,0.008800408,-0.007898559,-0.032979824,-0.11244577,-0.057463683,0.029796416,-0.029592797,0.019990198,-0.046591084,-0.1368787,0.03393793,-0.0034807192,0.019138008,-0.017409885,-0.028680997,-0.07490238,-0.0012794187,-0.00057518954,0.027881049,-0.002677684,-0.06999419,-0.118861504,0.042057637,0.036025383,-0.080873385,-0.061979104,-0.09401685,-0.058800142,-0.004575847,0.202201,-0.007827885 +1.14.13.186,"A cytochrome P-450 heme-thiolate enzyme. Involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.",384,0.99999994,-0.042097025,0.04032055,-0.080023736,-0.018219715,-0.01225257,0.062199,-0.054088473,0.11898407,0.038886696,0.012256763,-0.025630232,-0.034508,0.03750064,0.065139,-0.064228535,-0.011344664,-0.06521158,-0.02221432,0.012460602,-0.07281419,-0.00032412796,0.07791198,0.079750404,0.03135272,-0.018861476,-0.017418122,0.009434068,0.051767584,-0.06558781,-0.023558108,-0.04476147,-0.020963874,0.07742781,-0.053046376,0.06084047,0.09213978,-0.0425033,-0.009720764,0.12086587,-0.047699302,0.010419538,-0.05276635,-0.05891074,0.050113358,-0.019134697,0.00039305488,0.025791295,0.044273276,0.025148889,-0.021622296,-0.04841949,-0.0310853,-0.040473774,0.062193826,0.028382575,0.035020307,0.021503687,-0.047869723,0.00040390002,-0.086097874,0.028088627,0.012538034,-0.005904529,0.023780566,-0.07864044,-0.036156207,0.025933165,-0.026214283,-0.013447022,-0.05084197,-0.04417237,-0.06659879,0.0011814267,0.050829515,-0.060256597,0.03871091,-0.0023931093,-0.046081256,-0.033375636,-0.0033147032,0.08250191,-0.032489885,-0.04318585,0.11836241,0.047022864,-0.052607358,0.021470882,0.029147035,0.007940504,0.02843757,0.013782978,0.007781081,-0.010947959,-0.057048008,-0.114861764,-0.023706166,-0.06723613,0.02346633,0.07588806,-0.017657574,-0.0007879843,0.06193831,0.030843547,-0.039129164,-0.0035448465,0.008713416,-0.0011035354,0.060103424,0.09091864,-0.08638663,0.006611037,-0.027534777,0.02336671,-0.027023429,-0.0339055,0.07287916,0.07032417,-0.009275275,-0.017242456,-0.0016568044,0.015676513,-0.00336302,-0.0010359429,0.012874771,-0.0010530262,-0.018487776,-0.06027204,1.655274e-33,0.07090574,0.038571663,-0.018447533,-0.004096979,0.059445653,0.0031701059,-0.08514623,-0.014436161,-0.03958876,0.008445544,-0.1017975,-0.14833242,0.007073414,0.027709281,-0.019843686,0.004978898,-0.052473444,0.053354397,-0.009557633,0.02297157,-0.022918854,0.03497486,-0.039555583,0.009615422,0.047113508,0.14940123,-0.0095712375,0.03247349,0.04772348,-0.022959055,0.023236012,-0.035886172,-0.05968944,-0.018958582,0.062823966,-0.046576347,-0.032192856,-0.013239537,0.026985103,0.024263117,-0.04253194,0.019823004,0.03301103,-0.07656273,0.05740948,-0.051342033,-0.08178564,0.063284166,0.057756703,0.05924258,0.09862993,-0.10190609,0.07038906,0.038952164,-0.017648695,0.009869898,0.010079716,0.0806854,0.07291959,0.0567409,0.08345095,0.035309326,-0.017832767,0.054655164,0.06872876,0.030904641,0.0010796748,-0.008786056,-0.026615225,0.083925925,-0.06038528,0.044484425,0.02571634,-0.0095487945,0.0005759913,0.030435361,-0.05252819,0.0036983835,0.09993729,-0.02864326,-0.020417009,-0.02809731,-0.011056312,-0.029646344,-0.005207893,0.08464127,-0.0020514536,-0.0365475,-0.025477225,0.018074593,-0.03558033,-0.117887534,-0.0656806,0.0067155524,-0.0352627,-3.0716628e-33,0.08735211,-0.05304749,0.041214194,-0.10173388,-0.108787596,0.061885376,-0.08640371,-0.019910077,-0.04820911,-0.01349854,0.10162135,-0.039703988,-0.011266297,0.012551061,-0.015193417,-0.0766787,0.045066606,0.013490985,-0.07316517,0.010909337,-0.020771103,-0.0150412265,0.023163991,-0.03026511,0.046029057,0.029319912,-0.006945626,0.06491144,0.033607192,0.052236024,-0.056491233,-0.020301148,-0.03524226,-0.07681624,-0.027025966,0.1307171,-0.0031789313,0.008858363,0.084105134,0.010260076,0.049131934,0.021139875,0.009271253,0.067923605,-0.024989275,0.12090032,-0.099381015,-0.0012753761,0.042672295,-0.059460733,0.016274903,0.041498363,0.025369165,-0.009823395,-0.045628082,0.00045727598,-0.00968839,-0.05042563,-0.021668125,-0.08680999,-0.017926117,-0.025767962,0.05982916,0.020228455,0.013003425,0.08163992,-0.076403216,0.07145217,0.06341778,-0.029010015,0.002248708,0.03686042,0.015366769,0.03518425,-0.023532381,-0.00925908,-0.020859728,-0.052445598,0.09413996,0.057615317,0.021859605,8.165323e-05,-0.04651726,-0.044073354,-0.037395958,-0.07847333,-0.053909402,0.063716784,0.033182025,-0.025007341,-0.027156273,0.08669043,-0.01926331,0.02621037,-0.016185094,-2.9955896e-08,0.07019036,-0.05574539,0.03733084,-0.033590343,0.028401515,-0.012956539,-0.04192338,-0.022587053,0.042359658,-0.054042812,-0.0027269493,0.052420147,-0.053921133,-0.039125703,-0.01004899,0.024210837,-0.05582769,-0.02762886,0.0019766747,-0.040840793,-0.06130052,0.0025890511,-0.04786965,0.050338227,0.091558255,-0.078604855,-0.015858803,-0.03582938,-0.0031993673,-0.00048078995,0.054905437,0.043685544,-0.05925419,0.015444194,0.012662012,0.002209808,-0.10571968,-0.05982493,0.0038682846,-0.031468738,0.0073090084,-0.015582137,-0.11674659,0.0003834561,-0.056349043,0.0138188545,0.021455195,0.0120594315,-0.068483055,-0.02414512,0.030733773,0.04157831,0.052647345,-0.005791058,-0.14756693,0.04701189,0.09010283,-0.04458314,-0.06136877,-0.069412895,0.014060785,-0.062111314,0.20851658,-0.02220008 +1.14.13.187,"Requires FAD. Isolated from the bacterium Micromonospora carbonacea var. africana. The nitroso group is probably spontaneously oxidized to a nitro group giving dTDP-beta-L-evernitrose, which is involved in the biosynthesis of the antibiotic everninomycin. The reaction was studied using dTDP-beta-L-4-epi-vancosamine (dTDP-4-O-desmethyl-beta-L-evernitrosamine).",384,1.0,-0.06166482,0.04411762,-0.06615576,-0.023531409,0.059049614,-0.0023131801,-0.024919864,0.022066223,0.11829364,0.052625734,0.04987693,-0.03785172,-0.04191774,0.07898962,-0.049417112,0.023495484,-0.019987734,-0.051360834,0.0790001,0.03136445,0.040843014,0.044921238,-0.00608643,-0.028525606,0.02055631,0.017823383,-0.00935047,0.015817193,0.018834243,-0.07599784,0.019111188,0.06421917,0.026029255,-0.0760322,0.068650536,0.031993154,0.012418209,0.022738669,0.07123324,0.0315578,-0.027603772,-0.007660835,0.026145194,-0.0065709846,0.010896097,0.035155997,-0.042018604,0.086694255,0.051890913,-0.02757413,-0.032579422,-0.05723632,0.051631887,0.07024351,0.075681254,0.028917639,-0.08524094,-0.12072997,0.023351386,0.010596436,0.08657964,-0.029883679,0.04591988,-0.0055579753,-0.008443602,0.023965782,0.01365358,-0.080676086,0.043751113,0.0066619576,-0.06072532,-0.040642433,-0.004472049,0.07893107,0.035063524,-0.014008143,0.009893549,0.029377522,-0.010283041,-0.010994364,0.04988606,0.061555337,-0.012206957,0.06005834,0.054798752,-0.022586036,0.029810758,0.03521003,0.0644946,0.020526955,-0.046974283,0.059944827,-0.0010080156,-0.05587859,-0.018407404,-0.03930869,-0.059870128,0.030800037,0.04425969,-0.0037753747,-0.021222834,-0.052114926,-0.08290217,-0.0046861395,-0.1340598,-0.026163265,0.014638624,0.056318358,0.110176265,0.04682719,-0.032426517,0.028023219,-0.06556559,0.03789715,-0.077620246,-0.034031052,0.056175806,-0.027572775,-0.11360778,-0.013946467,-0.044286933,-0.014889256,-0.029241102,0.041860744,-0.0394409,0.0789315,0.015429513,1.5852844e-33,0.059926897,0.06727043,-0.056829806,-0.04536271,0.060443882,-0.03930087,-0.05316246,-0.0149708055,0.020431757,-0.051966842,-0.10313803,-0.06173184,-0.05969912,0.053660437,-0.0074189166,0.07466281,0.05278834,0.045134947,0.054350544,-0.041632783,-0.00064626645,0.06766652,-0.034633853,-0.020887451,0.030181807,0.07915605,-0.013668456,-0.010264485,0.10930886,-0.045845624,0.0627633,-0.09584556,-0.003871202,-0.026548441,0.058665175,-0.09015738,-0.054192837,0.00760041,0.044452928,0.036529016,-0.045294587,0.08753704,-0.050530743,-0.041633643,0.0318687,-0.015203717,-0.099814154,0.04399461,0.06789518,-0.008394374,0.040213674,-0.025539506,-0.03994222,-0.0096296165,-0.093045555,0.026525995,-0.022617726,0.006150437,0.028982526,-0.052535765,0.012704427,-0.003523095,0.05270785,-0.066888735,0.04521258,-0.02034695,-0.03303693,-0.007245236,-0.020667855,-0.028117334,-0.05140712,-0.018490683,0.005301832,0.05005058,-0.01210837,-0.0135865435,-0.05198656,-0.010061891,0.040721554,0.061534856,-0.011812819,-0.0040949592,-0.02052851,-0.050329477,0.03282966,0.031453017,0.011975809,-0.01605579,0.047388233,0.014354041,-0.013946003,-0.09762736,-0.07068733,-0.04628638,0.0065129395,-3.7629077e-33,0.12012703,-0.04309607,0.029674383,-0.05784721,0.025599785,0.07691446,-0.19203278,0.009371001,0.0154048605,0.008404729,0.07882603,-0.0278754,-0.007938436,-0.012319679,0.029059203,-0.06361712,0.009921488,0.100806266,-0.07934128,-0.0049422006,0.0042330455,-0.013313799,0.022244336,-0.014279514,0.023268474,0.00081100414,0.069764435,0.10019056,0.024935966,0.07114966,0.032232385,0.002613217,-0.09457687,-0.062886864,0.05893065,0.02426574,-0.031915694,-0.021116,0.017304609,-0.0051759225,0.086578846,-0.04145944,-0.05176034,0.006315595,-0.034613926,0.027496524,-0.119212836,-0.03781769,-0.018890359,0.026099402,0.078625806,0.037151292,-0.002246855,-0.05714038,-0.03364675,0.02017289,0.04183699,0.0511561,0.0025096193,-0.06636881,-0.014542324,-0.038528766,0.00045026722,-0.03154915,-0.025164267,0.105054386,-0.055191446,0.105738774,0.05427272,-0.0016576146,0.020942751,0.013393519,-0.015545284,0.03821142,-0.04909974,0.048125435,-0.040738583,-0.0789417,0.07719293,-0.018498654,-0.06805994,0.012770414,-0.01457477,0.004140304,-0.07654665,0.017975174,0.10423962,0.074097484,-0.0007923673,0.0398544,0.042085577,0.013199347,-0.009098304,0.033130616,-0.026746193,-4.505467e-08,0.07359835,-0.035371315,0.07640186,0.059785567,-0.039955545,-0.011313428,0.007145193,-0.022546042,0.048496567,-0.019940203,0.038617186,0.10495855,-0.008495303,-0.09744605,0.035037953,-0.008245344,-0.028739257,-0.039975952,-0.023777373,-0.004056906,-0.04767235,0.034266487,-0.016079096,0.01725236,0.03646082,-0.08981955,0.06163379,-0.046800748,-0.024081437,-0.03122545,0.00063159235,0.051654022,-0.0818567,0.03658932,-0.051194143,-0.05506199,-0.092273116,-0.04043905,-0.014582656,-0.049775172,-0.009058207,0.029388905,-0.08057781,0.017171007,-0.10565838,0.0059568267,-0.015086908,-0.014159166,-0.09975229,0.026581855,-0.020763857,-0.010647847,-0.0684841,0.01991209,-0.17676307,0.05042858,0.016657032,-0.05631388,-0.046945345,-0.07191298,-0.041910086,-0.069458425,0.102942176,-0.010213588 +1.14.13.188,A heme-thiolate protein (P-450). Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin.,384,1.0,-0.061320793,0.03434149,-0.10320672,-0.015067238,0.061583675,0.0259425,0.017709257,0.13738711,0.07548276,-0.032472268,0.0043957983,-0.018249664,-0.021195114,0.074862175,-0.02092303,-0.007631007,-0.05218789,-0.00020448501,0.014345888,-0.0995158,0.001057327,0.106516436,0.049567457,0.038390215,-0.005093253,-0.009414617,0.07809091,0.06275905,-0.041883882,-0.06676015,-0.0016683865,-0.07098994,0.06295121,-0.029209863,0.062286936,0.12015767,-0.08517414,-0.03869297,0.095212206,-0.037416715,0.08942051,-0.07922282,-0.042926032,0.045999944,-0.03170707,0.06209469,-0.032720633,0.06926195,0.032770168,0.007544808,-0.016786685,-0.024084354,-0.05761997,0.074528426,-0.011391831,-0.020818565,0.029905794,0.006604161,0.002911306,-0.04639832,0.04320009,0.0373437,0.01606903,-0.004397639,-0.084151424,-0.032686017,0.035714652,-0.042796127,0.024838982,-0.046648156,-0.035945594,-0.02968764,-0.013641912,0.12103405,-0.0346189,0.010860187,-0.015390242,0.007283732,-0.00056043005,-0.009919962,0.095865645,0.02289923,0.014866977,0.14233539,0.029115112,-0.005789881,0.008703464,0.049059328,-0.005245813,-0.07224285,0.028708572,0.023210397,-0.025057355,-0.027544025,-0.09335926,0.012266334,-0.031128239,-0.015268439,0.023162758,0.013037004,-0.0019524177,0.02995422,0.026040085,-0.07676242,-0.08347267,-0.010614271,-0.025192209,0.040730566,0.05687236,-0.0688867,-0.030970743,-0.028790904,0.02058413,-0.0664905,-0.023772612,0.08924449,0.035308186,-0.008248235,-0.029480284,-0.05891068,-0.029184835,-0.0065933354,0.069482654,0.035481732,-0.050003354,-0.017291395,-0.13311179,2.4753521e-33,0.053100854,0.029812643,-0.004148223,-0.0037042482,0.0019024613,-0.03102731,-0.042783804,0.022689478,-0.04589854,-0.016238848,-0.054945067,-0.1574975,0.009656182,-0.015778111,-0.016294513,-0.027383374,-0.024870379,0.060887076,0.020119352,-0.0015198361,-0.055000518,0.05909096,0.0126097975,-0.0007741977,0.061006263,0.07472096,-0.008793862,-0.011462735,0.10767886,-0.028338484,-0.009453122,-0.049911715,-0.027914677,-0.052239414,0.049106766,-0.027418764,-0.057933737,0.0037037304,0.0007237907,0.033360306,0.011010352,0.05844873,0.04411507,-0.06626314,0.06313828,-0.023061827,-0.09401468,0.052841853,0.03216536,0.0141121475,0.06514265,-0.05484108,0.096122034,-0.014600834,-0.081201985,-0.019929454,0.0037188241,0.09458623,0.0630791,0.0390383,0.12854522,0.06410622,-0.029188925,0.004524827,0.032941718,0.057352774,-0.058417756,-0.027766433,-0.027550647,0.09314973,-0.04729137,-0.0054697664,0.03077961,-0.040198274,0.006780528,-0.029875744,-0.0576326,0.031110534,0.04228197,-0.00033860005,-0.035659853,-0.022343092,-0.019908644,-0.009058946,-0.056520913,0.022637038,0.035043094,0.010326129,-0.030605955,0.012436452,0.040768072,-0.09696519,-0.05958402,0.04078774,-0.007291355,-2.2069188e-33,0.10664777,-0.046529595,0.04352796,-0.06574151,-0.010362001,0.06741158,0.0028196485,0.012246872,-0.044787843,0.044186752,0.14340013,-0.030057946,-0.02019694,-0.033611875,0.04843012,0.029560607,-0.0042096516,0.029490301,-0.040348526,0.06247404,-0.0062718247,0.039049458,0.026769014,-0.0188224,0.012307737,0.04511722,0.010255438,0.037102006,0.020059932,-0.0064071617,-0.080873884,0.004116671,-0.08713716,-0.07959206,-0.11822601,0.028649803,0.014080515,-0.033658244,0.031752553,-0.022501,0.0073824767,0.06306991,-0.0033325106,0.09412652,0.030179894,0.07679337,-0.038348604,0.004603807,-0.012082408,-0.029980082,0.010229493,0.0018458694,0.0009097572,-0.007024822,-0.055435244,-0.0079879435,-0.009630935,0.06906716,-0.03168228,-0.08215894,-0.05956163,-0.03728069,0.027277716,0.057288,0.031059949,0.08399397,-0.09616381,0.026071431,0.061076324,-0.039306644,0.041658252,0.018570181,0.0025851862,0.037501086,0.010659003,-0.0102963075,-0.012787938,-0.030210264,0.047719277,0.064186685,-0.035796545,-0.0148831345,-0.06869631,-0.015468734,-0.008475005,-0.064887635,0.0051668575,0.06737203,0.030312845,0.022396708,-0.008610713,0.050115753,-0.021193033,0.09693909,0.04665916,-3.193291e-08,-0.008243606,-0.1012015,-0.010364306,-0.04072457,0.010878903,-0.029143061,0.016697329,0.004360225,0.02162447,0.009064283,-0.035688583,0.029527957,-0.04875967,-0.020991668,0.026455758,0.0269585,-0.027025143,0.054216012,0.013819922,-0.016689587,-0.014184366,0.01593336,-0.021813769,0.010512062,0.06998469,-0.06837584,-0.029830169,-0.10089297,-0.029575443,-0.036093604,0.018741405,0.06204112,-0.06340309,-0.0025026093,0.051294222,0.056172084,-0.11661921,-0.024153972,-0.027302707,0.019615784,0.027962452,-0.012481961,-0.09009134,-0.008412876,-0.009902231,0.03989787,0.01017029,0.0138263395,-0.070999674,-0.06383539,0.018026993,-0.017788585,0.0016292415,-0.0686314,-0.16565877,0.025109231,0.035198525,-0.067711346,-0.034576293,-0.081761226,-0.0032378943,-0.055100862,0.23597261,0.0010944661 +1.16.1.10,"A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).",384,0.99999994,-0.01909311,-0.023731474,-0.13235259,0.11144909,0.0834983,0.006833335,-0.03224099,-0.010452666,0.0310092,-0.097273245,-0.019402483,9.040462e-05,-0.08037435,-0.035299126,-0.1096451,-0.031677943,-0.026588343,0.001970105,0.00056907826,0.038656604,0.037704296,-0.0387051,0.04384037,-0.03346669,-0.04824303,-0.018116368,0.00047065638,-0.018002061,-0.108397715,-0.08017807,0.002545643,-0.009767137,0.040703837,-0.047567032,0.0031819574,0.096161164,-0.047382805,-0.06282333,-0.0032346293,0.011507066,-0.030395921,-0.046119355,-0.030662809,-0.03539855,-0.04340222,-0.010901342,0.030979332,0.031354263,0.0138025815,0.10179802,-0.10889334,-0.0065683187,-0.11230818,0.07338483,0.024209272,0.02991981,0.010897729,-0.098641574,-0.044894177,0.0007505001,0.04143482,-0.013267518,-0.02738551,-0.014198081,0.0017279746,-0.05931332,0.036358047,-0.057096712,0.0013979742,-0.05606543,-0.01664379,0.039750844,-0.062030304,0.008367467,0.011924556,0.12120966,0.004160457,-0.018955147,0.083460994,-0.016511433,0.015683325,-0.029104346,0.011881226,0.047439434,0.049718175,0.013272913,-0.04099288,-0.018727293,-0.0012070403,0.0389033,0.06903065,0.06014081,0.016159644,-0.001397609,-0.02664977,0.009456477,0.020889387,0.060322568,-0.048777547,-0.013315287,-0.029239604,-0.003299691,0.04500933,-0.06624508,-0.023078086,-0.019044304,-0.064771645,0.13744505,0.01675722,-0.013489898,0.019223459,-0.05968505,0.07762569,-0.0043864925,0.024022188,0.11992475,0.06403977,-0.048286177,-0.11332681,0.02715264,0.04564759,0.039806087,0.04555475,0.039591525,-0.00042924896,-0.009968238,-0.14455843,3.494256e-33,0.08645432,0.08115191,-0.02164626,0.015495536,-0.00603884,0.014887735,-0.07913102,-0.03794483,-0.012760202,0.047413692,-0.07164257,0.013055021,0.04391925,-0.07513343,-0.013395772,-0.054950897,0.011238116,-0.034329206,0.03345859,-0.030973244,0.06628865,0.104312524,0.015945416,-0.0143431,-0.00088205043,0.044379987,-0.11335437,-0.0043411646,-0.029682767,0.035496976,0.049786024,-0.14316252,-0.09529292,-0.018604476,0.10101971,-0.01835614,0.0020807916,-0.089967944,-0.13336901,0.0006817866,-0.045297634,0.006352622,-0.044787526,-0.0064164884,0.07339353,-0.06620348,-0.04767646,0.13847212,0.026943183,0.04864536,-0.0103643285,-0.004140978,0.08826974,0.026096933,-0.09419042,0.030477826,-0.018256104,0.020113325,0.0134382835,0.079584636,0.052808374,0.056625716,0.020408498,0.050491814,-0.02890982,-0.027833153,0.0030623116,0.029180478,0.01474849,0.10106658,0.012697676,0.060209364,0.076785855,0.03230395,0.012118099,-0.03767682,-0.061213404,-0.08120681,0.023121677,0.0011941431,-0.013422372,-0.0127772065,-0.008066306,0.013347931,-0.046724554,0.060971137,-0.026864037,0.017045137,0.020375041,-0.013329414,0.0105245,-0.020489745,-0.043523725,-0.030806553,0.025080055,-3.888854e-33,0.029680843,-0.14034462,-0.011896398,-0.034206707,-0.051901903,0.049603213,0.031598225,-0.038052704,-0.030258106,-0.022422263,0.05726884,-0.023788223,0.0046404717,-0.09574869,0.049557574,0.010585446,-0.00060334645,0.024291225,0.038093504,0.03129523,-0.042464104,0.008781601,0.023132207,0.043489512,0.04370387,-0.0058264076,-0.016744984,-0.018944426,0.012953896,0.060533423,-0.02417239,0.024259426,0.0019931127,-0.113439105,-0.031677727,0.004982277,-0.015893025,0.014353718,0.09331138,0.051736362,0.04093768,-0.008234967,-0.007698058,0.03382615,0.06808291,0.01858182,-0.09666236,0.0823369,0.07924572,0.03966058,0.0181024,-0.008246918,-0.024613818,0.028560169,0.05279181,0.01366287,0.034178115,0.04914499,-0.047651548,0.10028604,-0.044959668,-0.078328654,0.06939689,0.010099152,0.09930412,0.12045016,0.022546917,0.10584651,0.04550663,0.015128666,0.09423306,0.004469067,0.010966181,0.028610962,0.05557211,-0.013440449,-0.007466685,0.07456957,-0.020995626,0.009962334,0.007942196,-0.010468442,0.056343433,-0.05530186,0.020482108,-0.13720408,0.029459333,0.02157441,-0.0098918965,-0.047031585,-0.0047164694,-0.072552584,0.010871909,-0.037462596,-0.019497557,-4.065772e-08,0.012086729,0.04428142,-0.0018099836,-0.061187867,0.059563402,0.0037975619,-0.010629626,-0.059049133,-0.033731885,-0.01213247,0.002389755,0.10996667,0.04784455,-0.0050653717,0.070985734,-0.0121703,0.008915245,0.04680306,-0.022345487,-0.021374019,-0.008467253,-0.023533205,-0.08367694,0.021830391,0.006592789,-0.050420687,-0.012285377,-0.08926947,0.06074227,-0.038119413,-0.030909847,0.0054645026,0.0036363632,-0.04391764,-0.06797098,0.03973306,-0.068087935,-0.028854487,-0.0662479,0.0638101,-0.06208388,0.0069405087,-0.03680145,-0.0144125605,0.005431893,0.014374742,0.022411587,0.0088068815,-0.0013642749,0.03452556,0.009898965,0.004998838,0.044054683,-0.05368982,-0.085720316,0.051521342,0.05679193,-0.023276614,-0.009592822,-0.084996864,0.0288692,-0.011397765,0.09084538,-0.05699333 +1.21.99.2,"This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.",384,0.99999994,-0.06999642,-0.051646844,-0.1846295,0.052636273,0.00928703,0.0047300784,-0.06923235,0.0053947447,0.047499355,0.01931333,0.07040588,0.025365952,-0.0866375,0.05257985,-0.01644929,0.10148831,-0.13749078,0.0019178042,0.022050325,-0.009805077,0.06438485,0.027358457,-0.0062725055,-0.08735731,0.052363947,0.025861278,0.059879225,0.0064216196,-0.017101794,-0.010672214,0.11002372,-0.013037688,0.107656956,-0.015231434,0.014726653,0.07205282,-0.040231228,-0.059268206,0.0931492,0.024142122,-0.022044526,0.025659068,0.025006458,-0.018474279,0.03286198,-0.00095280405,0.011289721,0.020708503,0.0717666,0.060193628,-0.056388646,-0.025279807,-0.035694424,0.008431707,0.07538958,0.01129028,-0.0076562637,-0.036358677,-0.0050248383,0.021704998,0.081160866,0.0035246734,-0.06284522,-0.026321525,-0.0509119,-0.0058613927,0.013363591,-0.06072273,0.04412994,-0.031610243,0.018991876,-0.048846517,-0.021771412,0.03440652,-0.034591768,0.04085913,-0.020116176,-0.040790983,0.02215743,-0.0045672064,0.038955774,0.01986138,-0.0013102256,0.11664086,0.066939674,0.031602424,-0.0152699435,-0.015773626,0.0045599965,0.07088544,-0.022468159,-0.045338653,-0.027439164,-0.08347602,0.0172263,-0.011761332,-0.017997531,0.04089256,-0.06755882,-0.041452512,-0.02944044,0.03330784,-0.03502653,-0.1130242,-0.059404265,0.019366957,-0.0028555272,0.08922887,0.05294187,-0.0017979086,-0.064747564,0.06037819,0.009629709,-0.038617574,0.016718507,0.043511935,0.055172794,-0.038523484,-0.072243564,0.044076093,-0.007675203,0.061285857,0.029443156,0.090229504,0.010541213,0.01609084,-0.12536438,-5.7303917e-34,0.055089805,0.09376252,0.016254574,-0.05028454,-0.01002629,-0.037379537,-0.0500013,-0.08376638,-0.006511093,-0.01855699,-0.080310196,-0.051359504,0.017445534,-0.040374253,-0.046453573,-0.018878238,-0.012282664,-0.042147357,0.043966163,-0.04888229,-0.09007136,0.053532287,-0.09193408,-0.089848466,-0.006855028,0.025237385,0.034389377,0.0041466947,0.038189657,0.022356063,-0.068404004,-0.016853841,-0.13636656,-0.027323565,0.03150527,0.013737874,-0.06431532,-0.1153811,-0.026764778,0.059182122,0.05159049,0.01744108,0.009343252,0.06064139,0.04797307,0.00401531,-0.033864442,0.060191255,0.1172877,0.038172815,-0.008232712,0.003956397,0.10993371,0.006499698,-0.058871843,-0.05339259,0.016598709,0.07314588,0.012242195,0.09522443,-0.009827838,-0.06858565,-0.026558986,0.06847107,-0.05554183,-0.030424235,-0.053545702,-0.061783627,0.0040352973,0.116575494,-0.0138531625,-0.0054442077,0.06686697,-0.0049606203,-0.0015170627,-0.030546622,0.0013883015,0.06335172,0.022891656,-0.05822907,-0.06844775,-0.072489314,-0.011425335,-0.02432511,-0.03197179,-0.007138887,-0.022314763,-0.042301916,-0.051238786,-0.017673219,0.027382014,-0.07456715,-0.051459525,0.0594929,0.048499633,-1.135973e-33,-0.04388935,-0.08530513,-0.000968098,-0.08006844,-0.07511373,0.042341817,-0.0053434926,0.028437175,-0.002613952,-0.0022840367,0.050903596,-0.07239515,0.076244436,-0.058861185,0.018639524,0.0152741615,0.057118535,0.059617694,0.006957766,-0.026672855,0.016138982,0.08729667,0.059221186,-0.017004281,0.025583949,0.02819402,0.020396132,0.0569574,0.04361965,0.08685514,0.03021827,0.04223407,-0.07878513,-0.07550593,0.028611928,0.033686757,-0.010894083,-0.0025184497,0.016927054,-0.015924232,0.025182553,0.05339885,0.044806685,0.11666012,0.05054086,0.09478324,-0.0047876956,0.059164077,-0.021541605,-0.08468022,-0.015589374,-0.0044928095,0.00797967,0.038047507,0.010170578,0.029896315,0.020215409,-0.037622094,-0.026974373,-0.046872802,-0.09825467,-0.025246946,0.0440926,-0.029152853,0.0127715655,0.036245026,0.052610476,0.03314263,0.026352957,0.006054293,0.03342616,-0.016587239,-0.012548493,0.1015527,-0.047264267,0.017643489,-0.08622189,-0.032685287,0.028699351,0.00840379,0.011330729,-0.02042158,-0.026567934,-0.020421755,-0.023273032,-0.10129499,0.040577143,0.09596302,-0.014159782,0.017670479,-0.028554749,-0.0010850123,-0.104936615,0.0595527,-0.0016908945,-2.8610957e-08,0.035544112,-0.051232733,0.04012856,-0.050704677,0.067398235,0.030385643,-0.03362426,0.060393073,-0.00624694,0.011791327,-0.05747954,0.08215032,-0.027329708,0.002559686,-0.0064986343,0.026622484,-0.011383413,-0.009609644,-0.0036066642,-0.03793653,-0.01623113,-0.0019230099,-0.041473735,0.04537274,-0.07413352,0.015470903,0.052289817,0.044550158,0.019836573,-0.016430404,0.0324561,0.052365474,-0.046972785,0.010372312,-0.179261,0.04853623,0.035581212,-0.022483105,0.005824528,0.05074985,-0.006643051,-0.09490245,-0.0209171,0.056324396,-0.0070519596,0.016997863,0.017833661,0.03310326,-0.027583644,-0.044278547,0.004354815,-0.031222476,-0.04060967,-0.008393641,-0.13895068,-0.009097501,-0.059051502,-0.03678508,0.05299594,-0.055476982,-0.014448151,0.016582357,0.14386036,0.012942341 +2.1.1.294,"The enzyme is involved in the biosynthesis of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a. O-Polysaccharide structures vary extensively because of differences in the number and type of sugars in the repeat unit. The dual kinase/methylase WbdD also catalyses the preceding phosphorylation of alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.7.1.181, polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase).",384,1.0,-0.040418904,-0.035132468,-0.1265464,-0.043083012,-0.007639293,-0.008665932,-0.0051354226,0.013631172,0.11048379,-0.001445778,0.009274215,0.0041101673,-0.08262401,0.0052440385,-0.049892634,0.008484253,-0.10625581,0.068591066,-0.026130846,-0.0298965,0.10745064,-0.04898971,-0.03585788,-0.019825643,-0.045629058,-4.0368795e-05,0.040320765,0.009043685,-0.007969234,-0.08861918,-0.009295795,-0.04236801,0.10877904,-0.021000449,0.08210317,0.086473554,-0.01766846,-0.04787019,0.020219518,0.0112660015,0.05657036,0.015363544,0.032242242,0.03331757,-0.05852063,0.033069722,-0.10564384,0.020718193,0.04717723,-0.015387391,0.014099037,-0.08287083,-0.04337781,0.07490529,0.080460206,0.017430106,-0.039031472,-0.032443512,0.016655784,0.009273238,4.4419605e-05,0.019211978,0.044316523,0.03217984,0.010054011,-0.041906673,0.050989926,-0.047759786,-0.012171659,-0.031231698,-0.050161436,-0.006839147,-0.008716018,0.010526373,0.009833226,-0.012097138,-0.047587488,0.015053324,-9.8947334e-05,-0.04199342,0.07780628,0.02472604,-0.025092635,0.06325334,-0.054711264,0.035404414,-0.056514792,0.02615653,0.11449516,0.08973024,-0.031526625,-0.048821066,0.016728196,-0.07324191,-0.061379608,-0.0009746035,0.032646697,0.10122071,-0.006704752,0.020675218,-0.013554986,-0.03026869,0.020929378,-0.07602583,-0.027430149,-0.019998921,0.023641193,0.0645043,0.004767124,0.020267593,-0.047761515,0.043204322,0.04335835,0.021542773,-0.08174495,0.0106933145,0.038734958,-0.06996243,-0.029258834,-0.0150926085,-0.022538187,-0.04473088,0.074880086,0.06429019,0.0016693637,0.051881585,-0.06398256,-2.8288793e-33,0.06587654,0.036102958,0.051850602,-0.03454491,0.0155670475,-0.044295687,0.027068729,-0.068215385,-0.042463925,-0.028950464,-0.095057994,-0.08479668,-0.0052740728,0.04744572,0.021002872,0.007580789,0.03464745,-0.040324695,-0.038286865,0.012670918,0.0015430464,0.061380666,-0.0276459,-0.04334459,0.07885877,0.014513705,-0.034452185,-0.0024123595,0.07228086,-0.014553933,0.011959843,-0.0203169,-0.10758689,0.1053758,0.103346005,-0.04358501,-0.09911377,-0.041701272,0.0050072116,0.054492056,-0.012650965,0.027434466,-0.024025805,-0.028034467,0.041753367,-0.044660058,-0.011148388,0.08216437,0.07402865,0.04616892,0.0018958868,0.024531972,0.06478081,-0.02124034,-0.041936673,-0.048413035,-0.041011035,-0.02855793,0.0061672223,0.10774425,0.013647305,0.047599155,-0.005439194,0.043573175,0.0074669705,-0.001180188,-0.094963595,-0.01808574,0.0021931762,0.059821893,-0.026610736,-0.12727569,0.03652898,-0.007355452,0.06313376,-0.007646657,-0.022708232,0.026910216,-0.023373337,0.015082275,0.039510645,0.025247673,0.008550466,-0.033633478,-0.14867455,0.07995213,0.032326084,-0.06537228,-0.042440526,0.10521081,-0.0031719585,-0.079129346,-0.037989307,0.072066255,0.052695498,-3.4570396e-34,0.028921202,-0.09181115,0.10528668,-0.11197131,-0.055037394,0.051472425,0.0015456768,-0.017282585,0.027859116,-0.025656937,0.025626548,0.08729699,0.023391694,0.0122795375,0.0007837765,0.0009153547,-0.023800882,0.16576993,-0.0039345166,0.008634504,0.014702132,0.08073163,-0.02034851,-0.022031337,0.0661714,0.0026933185,0.052332174,0.12607577,0.00391384,0.020677237,-0.014564808,0.0048840665,-0.05282026,0.03668824,-0.048553687,-0.018119592,-0.029393274,0.007751172,0.026099807,0.053460192,-0.07751021,0.062210854,0.016457766,-0.022750188,0.052148554,0.11177869,-0.06194761,0.023385683,-0.0029312286,-0.034145113,-0.007319179,0.009607555,-0.045627426,0.065760955,0.030443083,0.010682945,0.058313012,0.048290376,-0.032724053,-0.08602907,-0.05204547,-0.057226107,0.044066112,0.015952082,0.046501786,0.04731496,0.04045056,-0.042598672,0.024435895,-0.0143625345,-0.019417308,-0.033831663,-0.047675233,-0.015431936,0.016273249,0.00081646896,-0.09287886,-0.03625074,-0.02790101,-0.0401345,-0.071665816,-0.032587897,-0.013551403,-0.0005097709,-0.032444704,-0.018978244,0.120907225,0.08162254,-0.04320449,0.07478285,-0.014411852,-8.65439e-06,-0.068533204,0.10581659,0.10059686,-5.6307808e-08,0.030723399,-0.09815458,-0.044153385,-0.07801597,0.011720023,-0.0016202023,-0.01919502,-0.03534303,0.04862625,0.039200813,-0.008471467,0.120001815,0.03142792,0.0036564935,0.039373476,-0.0100619495,-0.033060864,-0.020550799,-0.0061515495,0.010073443,0.0012709916,-0.038991466,-0.08632164,0.040863853,0.023222843,-0.09025615,0.005155712,0.049416896,-0.055902217,-9.191642e-05,0.040871374,0.021834584,-0.016059384,-0.10726141,0.008893812,0.027272483,-0.060257107,-0.057431407,0.050887965,0.04576272,0.055781476,-0.018659435,-0.008478769,0.044521432,0.027660199,0.014919477,-0.0077864397,0.05427547,-0.055431392,-0.0023746998,0.06375016,0.0003736408,-0.02815894,-0.086501345,-0.07535193,-0.08774734,-0.03243708,-0.034770276,-0.009911517,-0.03594314,0.02842145,-0.049915053,0.13354523,-0.061896127 +2.1.1.295,"Involved in the biosynthesis of plastoquinol, as well as vitamin E (tocopherols and tocotrienols).",384,0.99999994,-0.055641286,-0.056399025,-0.04456944,-0.012289078,0.050465558,0.08935488,-0.06634775,0.078003615,0.006813028,-0.011489278,-0.0008621322,-0.038421538,0.04304089,-0.016307244,-0.06533237,0.04692797,-0.06324591,0.064605236,-0.040839,-0.025227664,0.025746062,-0.035850294,-0.006407723,0.076264754,0.061755568,-0.0020498207,-0.060030956,0.028084185,-0.06315519,0.030957518,-0.0114539955,-0.027175713,0.0022397698,-0.1083353,-0.04923533,0.12480443,0.031559635,-0.019311337,0.03070484,-0.0068241567,-0.020389207,-0.07567859,-0.08453338,0.02405451,0.06258335,-0.0020406495,0.03604743,0.06482029,0.013953735,0.047850944,-0.023202963,-0.0074231736,-0.12752947,-0.04718262,0.08662693,0.05488577,-0.04733372,0.02478674,-0.05554663,0.01794728,-0.019569479,-0.08149709,-0.022898857,0.0681578,-0.02107627,0.038079944,0.032502923,-0.022553345,-0.026998207,-0.03763384,-0.03369868,-0.09254158,0.0093859965,0.03609594,0.017658481,0.0958067,-0.024767678,-0.019666323,0.04190663,-0.021896238,0.05329396,0.041610286,-0.061980728,0.098335974,-0.024133088,-0.042932034,0.038644865,-0.057036795,0.0657232,0.07496708,0.045166507,-0.03113325,0.009123439,-0.018525798,-0.064110145,0.059598003,0.044639464,-0.02064608,0.05383626,-0.07554092,-0.0042229015,-0.036456045,-0.03832944,-0.060571935,-0.081357494,-0.008374,-0.06425582,0.016594648,-0.016227758,0.015966848,0.012859035,0.007746902,-0.01838021,0.022420745,-0.054136205,0.01968031,0.06924285,-0.07121263,-0.08052993,0.010858832,-0.0034385982,0.041077763,0.057554554,0.043651823,-0.057497416,-0.07094306,0.0453923,-1.981243e-34,-0.014621869,0.0501718,0.016606066,0.0313058,-0.0058214427,0.0048191394,-0.06613582,0.048096813,-0.03486844,-0.05299492,-0.031032965,-0.027826458,0.0030351393,0.066644706,-0.018236289,0.024734361,0.044520978,0.0008375304,-0.018451178,0.0068957126,-0.04992984,0.06312065,0.013029439,0.0048414133,0.017885275,0.04346062,-0.085177265,0.011130165,0.01152503,-0.018269036,0.028052032,-0.09135435,-0.014227533,0.005831594,0.017123073,0.009274896,-0.07767519,-0.031927433,-0.013830118,0.09730734,0.053327534,0.05873985,-0.07605045,0.012957023,0.0003758366,0.01176217,-0.01868073,0.054864332,0.056189682,-0.011259547,0.0177269,0.055423066,0.07730184,0.0090197595,-0.044207815,0.008385559,-0.0014378236,0.0065893196,-0.008141543,-0.009148512,-0.04790058,0.095310934,0.08477939,-0.015877573,0.007501971,-0.033378266,-0.11895828,0.034068253,-0.031735964,-0.0043483027,0.07479952,0.031207204,-0.014413218,-0.02642919,0.051395908,0.0028333568,-0.041791417,0.0145590035,0.0010275678,-0.04856599,0.009439163,0.020934286,0.05655562,-0.017057765,-0.07221374,0.028117942,0.009677308,0.008894535,0.01989542,-0.010189597,0.067684144,-0.038815618,-0.019003691,-0.0631783,0.021455968,-2.5075998e-33,0.030560935,-0.08243511,0.09337722,-0.022405846,-0.015071167,0.07587621,-0.087788135,-0.022322997,0.02258467,0.07480953,-0.0046088854,-0.04666171,-0.0068501695,-0.026080083,-0.03324223,0.049674965,0.023381555,0.14993232,-0.017552387,-0.032287803,-0.026403043,-0.013315953,0.042036712,0.01448325,0.012396504,0.028566655,-0.031597238,-0.04570949,0.053979453,0.045686048,0.014320474,-0.06955063,-0.06406152,-0.014906204,0.054806292,0.04412823,-0.0048918184,0.06285284,-0.018172657,0.004489863,-0.0045950646,0.0030653223,0.057758827,-0.04990009,0.029908303,0.028163804,-0.0796628,0.028350458,-0.022228425,-0.009794328,0.13229762,0.0393428,-0.019006938,0.017836291,0.0548606,0.004210337,-0.0041012825,-0.041329894,0.0799963,-0.11382543,-0.06569866,-0.11015065,-0.076256834,-0.024032677,0.024822114,0.07434377,-0.055119723,0.03227239,-0.02426357,-0.056723207,0.09342062,-0.04641719,0.013253904,0.010765258,-0.009400739,0.046576854,-0.02682007,-0.1276226,0.0014708143,0.034866974,-0.009404424,-0.0318368,0.026814025,0.0053657196,-0.07885653,-0.05220601,0.037807964,0.059438217,-0.02124215,0.024498519,-0.015396818,0.011062025,-0.07902544,0.059760712,0.14815028,-2.7568497e-08,0.090666585,-0.08105605,0.014969161,-0.029639583,-0.038806576,-0.026238872,0.0701787,0.03451016,0.07145426,-0.029235084,0.016157432,-0.004343139,0.06261123,0.04559396,0.09191987,-0.006669703,0.0322174,0.021943497,-0.03066425,0.02581712,-0.11476446,-0.013476014,-0.049658015,-0.041579455,-0.0062484914,-0.11590641,0.03739837,0.01673117,-0.009603627,-0.016227592,0.011631766,-0.05728557,-0.048679516,-0.0665689,-0.09135647,0.032046143,0.0008632902,-0.010880486,-0.00478949,0.07970925,-0.052412495,-0.10866452,0.008022774,0.08925796,0.011056975,-0.028487181,-0.004727621,0.088860884,-0.0018271606,-0.024611225,-0.03399229,0.01741998,0.053078458,-0.17930534,-0.11721452,-0.0141768055,0.04325051,-0.021309642,-0.00085033226,-0.08771529,-0.03974146,0.028827664,0.17181975,-0.041834664 +2.1.1.296,"The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the ribonucleotide at the second transcribed position of mRNAs and snRNAs. This methylation event is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream ribonucleotide is not methylated (see EC 2.1.1.57, methyltransferase cap1), but with lower efficiency [2].",384,0.99999994,0.04647933,-0.030345226,-0.112627394,-0.03169349,0.022056416,0.056083698,-0.03941602,0.022437835,0.02295185,0.011637719,0.030108515,-0.025459338,-0.08424789,0.035568353,-0.029494831,0.051473934,-0.123110786,-0.035324484,0.07008339,-0.0005665515,0.08637409,0.11363513,-0.006813714,-0.047433816,-0.012962218,0.017739246,0.00019220798,-0.024336265,0.055668525,-0.032099955,-0.02920472,-0.023115499,0.0434989,-0.01655128,0.016543357,0.080239266,0.013638869,-0.0390116,0.034011174,0.037424713,0.048335508,0.044408847,-0.033265144,-0.019934507,-0.028552804,0.020095643,0.05369404,-0.038794927,-0.020566948,-0.0031207774,0.0024492205,-0.097486615,0.0062655346,-0.028596006,0.0074257366,0.024285346,0.024632623,-0.05664423,-0.011273758,0.004170321,-0.001621532,-0.002700162,-0.040834364,0.0007111847,0.10691305,-0.038514923,0.056317937,-0.016692251,-0.040361233,-0.06088713,-0.0763583,-0.08296254,-0.102870286,0.06639073,-0.03763039,0.0074952478,0.038458537,-0.03584394,0.07374199,-0.0034674753,-0.08403246,-0.042740174,0.04644923,-0.046875812,-0.036412362,0.054638274,-0.020505382,0.091915146,-0.016031757,0.026214598,-0.047229156,0.010590324,0.05677482,-0.022731049,-0.04923015,0.041180104,0.05412329,0.08403725,0.07530353,-0.03292466,0.018675167,0.036907773,-0.11951556,-0.052636378,0.058278814,0.05768599,0.039683897,0.03437351,-0.017460043,-0.01044151,0.008338205,0.08221106,-0.0034157683,0.00091707153,0.044061746,0.02909994,0.069298685,-0.062999465,-0.0074875723,-0.046122078,-0.02948439,-0.04622585,0.06211005,0.0081547825,0.009793288,0.006986248,-0.11244991,-7.460681e-34,0.05642394,-0.0013799089,0.03175495,-0.03327913,0.008023822,0.06627368,-0.04717414,0.018616568,-0.0024932188,-0.035286084,-0.08374064,-0.15870301,0.04540028,0.03137009,-0.0013543,-0.0066000177,0.001909823,-0.021894615,0.004688078,-0.03364308,-0.013554003,0.03372429,0.025881404,-0.028334932,-0.021932922,0.025762282,0.0043659885,-0.0753904,0.0809589,-0.027672471,-0.018782135,-0.064858064,-0.052181333,0.05209878,0.06597298,0.021983912,-0.017855078,0.043354735,0.0060497257,0.11597462,0.12934458,-0.014034657,0.0172624,-0.053893924,0.03979531,-0.02775261,-0.1041947,0.011793944,-0.04175554,-0.021045301,0.0077850157,0.021320993,0.05096155,-0.038934045,-0.013975092,0.022553397,0.037156507,0.008877725,-0.060547784,0.07430474,-0.049928684,-0.038136177,0.02102016,0.08847456,0.02070522,-0.06194162,-0.06182542,-0.07448626,-0.027834339,0.09520687,0.007011497,-0.06423798,0.12408792,-0.02213276,-0.0022732548,-0.030967072,-0.07257596,-0.018918557,0.0639739,0.044907223,-0.040400222,-0.0091937,-0.012062787,-0.0647509,-0.026821267,-0.0389194,-0.0040538823,-0.122184396,-0.007902631,0.082755886,-0.038532875,-0.024019726,-0.045646753,-0.023225723,0.039281726,-2.628894e-33,-0.0002113519,-0.032946985,0.04389843,-0.09142047,-0.038407117,0.049322363,0.06303694,-0.054304503,-0.08398946,-0.08327788,0.07599146,0.040897097,0.028707825,-0.025696367,0.037734374,0.018225962,0.00031216771,0.08024955,0.054159988,-0.024386762,-0.007942702,0.01814184,-0.030583754,0.062146194,0.062341742,-0.029520463,-0.037393223,0.051400382,0.058739796,-0.013019671,-0.065981284,0.06832247,0.015207384,-0.061184045,-0.0011041331,0.028851755,-0.054735173,-0.052529406,0.03149039,0.057471536,-0.02788715,0.07564143,-0.02713072,0.06292777,0.018175405,0.033416882,-0.08670294,-0.056076303,-0.022083692,-0.036071576,0.04887127,-0.028995506,0.048366334,0.05455776,0.024032388,-0.0034499385,-0.027364183,0.022598317,0.043215446,-0.006668042,-0.047073208,-0.050035316,-0.031712975,0.030227525,0.033656027,-0.025687667,-0.022651384,-0.0041893525,-0.01393883,-0.051210996,0.071266286,-0.03223056,-0.029163407,0.037342474,-0.06886493,-0.06311001,-0.079688676,-0.0338822,-0.056005314,-0.08837794,-0.009644169,0.05439871,0.0018678757,-0.020602839,0.008789072,-0.09760745,0.03005117,0.10042867,-0.051996868,-0.027672471,-0.05241214,0.0061199437,-0.1021995,0.069632925,0.018005297,-4.1980364e-08,-0.026520634,-0.07180486,0.024040774,-0.057409894,0.0021496713,0.09022081,-0.041448932,0.030905815,0.051986963,0.0024561551,-0.007181005,0.04550055,-0.0033711803,0.035225384,0.064869456,0.04664383,-0.0528962,0.029597279,0.0069077075,0.027046897,-0.06748885,0.09537192,-0.09012773,0.03842691,-0.08585029,0.017663963,-0.020474859,0.15037891,0.06978769,-0.057740364,0.031251404,0.07442098,0.07288933,-0.04819561,-0.05556463,0.0036999176,0.062895,-0.052648827,-0.019404683,0.029335665,0.07407896,-0.010204418,-0.049454093,0.0024496722,0.0022217138,-0.016726838,-0.0058678635,0.11914439,0.0305373,-0.038456608,0.019422263,0.026546644,-0.010923136,-0.06834033,-0.056638855,0.0048720017,-0.088874735,-0.03406028,1.4728577e-05,-0.0029725798,0.08766291,-0.012917604,0.15080917,-0.082514256 +2.1.1.297,"Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity.",384,1.0,-0.008713166,-0.027861819,0.034659836,0.02138395,0.004921875,0.077901766,0.047613367,0.026018295,0.03512324,0.027124729,0.013826339,0.04632739,0.009311236,0.020012105,0.0002700125,0.020797009,-0.01561568,-0.0153562855,-0.113134205,-0.019062135,0.070623145,0.043891266,-0.013841982,0.0060993144,-0.07369392,-0.020405121,-0.018153196,-0.032530036,0.096889555,-0.040093414,-0.0055655204,-0.02665784,-0.0723702,-0.0041882945,0.046880875,0.09836208,-0.09523437,0.020199127,0.050881226,0.0071675256,0.01777423,0.03804275,-0.04937443,0.0033162448,0.0152715845,0.043337867,0.0146025,0.03058979,-0.03624997,0.06957939,0.08750677,-0.017675819,0.034759693,0.051957063,0.06251018,0.037599508,-0.11975078,-0.016528757,-0.0600001,0.079472795,-0.11948148,0.042263255,-0.06416605,-0.09369086,0.03214001,-0.032907832,0.06839458,-0.024503943,0.031250197,-0.017574769,-0.072442286,-0.053668335,-0.031180467,-0.03823745,-0.02973067,-0.0006757865,-0.07208549,0.013426722,-0.0037675407,0.034566347,0.11123705,-0.07907635,0.07873308,0.11732839,-0.07965612,-0.03547537,0.062306315,-0.015076639,0.027810592,-0.04003946,0.018022478,-0.06977012,0.0614013,0.0029914223,0.01213068,-0.09255081,0.03096653,-0.05757395,-0.038830735,0.03279506,0.018478433,0.036027525,-0.06845217,-0.0176894,-0.01401819,0.027225506,0.037037645,0.058487818,0.049028866,-0.008136053,-0.0015620942,0.11891912,0.02849208,0.022012904,-0.06898168,0.053571295,-0.0006786598,0.018202813,-0.0155145265,-0.046690863,0.031014305,0.02324175,0.014006605,-0.009102927,-0.10565837,0.013957371,-0.0057176366,2.5648693e-33,0.012420875,0.003978188,0.047613483,-0.032239597,-0.050894894,-0.03205806,-0.081772916,-0.03693877,0.055006415,-0.0006083163,-0.052882858,-0.06076653,-0.047613412,0.10053777,-0.03758032,0.08051489,-0.07384742,-0.026162326,0.11928313,0.008099104,-0.019038796,0.02361839,0.046855584,0.02083524,0.018436177,0.070807464,-0.049326014,0.008449534,-0.034642998,0.0019605267,-0.031889975,0.014872386,-0.072266996,0.015791124,-0.0033840446,0.038869537,-0.018561235,-0.103842214,0.07539727,-0.022612156,-0.025934072,-0.011516169,-0.011013775,-0.042489227,0.010621423,0.003961996,-0.061846104,-0.03942554,-0.093304075,0.013930192,0.038372114,-0.032608062,0.03006719,0.05202564,-0.098582044,-0.029667081,0.024456926,-0.081015795,0.003385646,0.10095471,0.005165077,0.09697658,-0.006838626,-0.021137837,0.06257703,0.03303722,-0.0752413,-0.005533025,-0.07045515,0.043671444,0.013765726,-0.017793676,0.047486145,0.014228814,-0.0012306097,-0.061259124,-0.04346479,0.010402041,0.030364748,0.019454164,0.021052107,-0.023008814,-0.01715167,0.008551955,-0.053673197,-0.032329418,0.09258915,-0.11081176,-0.008040587,0.00085338985,-0.0660903,-0.006300451,0.029169153,0.035352416,-0.043804176,-4.8954807e-33,0.031668283,-0.06204671,-0.003836746,-0.0051876935,0.030185837,-0.054270804,0.021178814,-0.011860072,0.018502492,0.03477136,0.033600207,0.03342706,-0.097354904,0.09244627,0.030173628,-0.04844581,-0.060313113,0.05718951,-0.064927705,0.014182948,0.05574821,-0.023060963,-0.033818994,0.03184837,0.10524247,-9.7404234e-05,0.018912623,0.026421163,0.03816204,0.046475556,-0.08790411,0.049138974,0.027435709,-0.09003613,0.072411396,0.027213743,-0.053890385,0.035329692,-0.0826013,-0.049934432,-0.040847063,0.09519618,0.04432215,0.06279588,0.1061489,0.11778652,-0.049442753,-0.009078526,-0.037288144,-0.010890549,0.055505607,-0.028935116,0.015354604,-0.038789764,0.019859256,0.020564893,0.009156625,-0.043127634,-0.012117709,-0.009099506,-0.045018885,-0.012865227,-0.0818614,-0.045161325,0.089802824,-0.0034294736,0.09045672,0.0070331865,-0.007006539,0.020255793,-0.00368847,-0.09181967,0.11187156,0.018810565,-0.027366174,0.054715253,-0.14692959,-0.0594439,0.0025420235,-0.040386666,0.035676174,-0.010762474,0.018437857,-0.012948471,0.0132457465,-0.05141769,0.0013192081,0.07747283,0.003436096,0.015212779,-0.042243127,0.017237127,-0.0052147456,0.02070398,-0.0102470815,-3.180466e-08,0.06934219,-0.045554776,-0.032700922,-0.020097408,-0.0064700935,0.030675035,-0.03353383,0.043873683,0.00035921935,-0.030637044,0.027737094,0.07787844,-0.05682758,0.03239118,-0.08122827,0.051577035,-0.07657436,0.015134812,0.0040609105,-0.053623475,-0.14481279,-0.0103138685,0.03174077,-0.012309199,-0.03101841,-0.12038357,0.031858966,0.08914183,-0.016530853,-0.037310142,0.09314844,0.029878752,0.023731573,-0.010320264,-0.03956416,0.073406264,-0.010243845,-0.015253334,0.12916252,-0.018949239,-0.07658495,0.055141535,0.00017687028,0.02168977,-0.008965232,-0.018558608,0.050211348,-0.0018270342,-0.031344716,0.026597677,-0.046032976,-0.010876834,-0.06190195,-0.025630325,-0.000952597,-0.035892267,-0.11504838,-0.03754015,0.069813855,-0.1321537,-0.008884852,-0.0039987788,0.08450896,-0.009301804 +2.1.1.298,Modifies the glutamine residue in the glycylglycylglutamine (GGQ) motif of ribosomal protein uL3 (Gln150 in the protein from the bacterium Escherichia coli). The enzyme does not act on peptide chain release factor 1 or 2.,384,1.0,-0.030119967,-0.062004883,-0.05821506,-0.019160403,0.0044659227,0.044011258,0.007050787,0.028463777,0.011544204,-0.021773834,0.03064214,0.025540862,0.01739982,0.030061234,-0.043816175,0.012160469,0.024270399,-0.010381549,-0.09462201,-0.086742125,0.13452104,0.047950033,-0.01423993,-0.026847038,-0.025113134,0.0056860573,0.034662142,-0.0595975,0.055766653,-0.057732265,-0.026508555,-0.06485684,-0.013716563,-0.018675212,0.05740138,0.040994808,-0.09211419,-0.005834228,0.07710474,-0.0069743223,0.03258564,0.02089833,-0.010620444,-0.015913585,0.025233433,0.043618053,-0.013135615,0.10726264,0.011485025,0.04443221,0.05842724,-0.04570225,-0.00020155669,-0.011506271,0.09163558,0.007981019,-0.088039264,-0.06412682,-0.015633287,0.03572547,-0.07084934,0.039985836,-0.04794592,-0.065542445,0.069376245,-0.06514321,0.12688713,-0.05797277,0.0037039258,-0.003924105,-0.022002818,-0.09934092,-0.037364066,0.014184327,-0.007537994,0.030649154,-0.037029833,0.001246514,0.02680871,0.008842563,0.060287215,-0.08839167,0.1281978,0.12002352,-0.06120776,-0.021156125,-0.007799079,0.0018039504,0.010745375,0.0052430285,0.06839453,-0.05981812,0.037137132,-0.015905127,-0.0010026435,-0.026407046,0.009470946,-0.04022464,-0.01099164,0.010756635,0.022587398,0.059151854,-0.006748649,-0.012496579,-0.02493883,0.044947926,0.024956692,0.09752776,-0.018771196,-0.020698385,-0.0019534973,0.08675469,0.038372215,-0.027537266,-0.03609244,0.053380415,0.11072886,-0.0535044,-0.073914744,-0.038473006,0.030482028,0.011859414,0.011863425,0.08394976,-0.07574115,0.025514632,-0.02620849,4.3000256e-33,0.037612606,-0.012072631,0.046164494,-0.060310517,-0.019887537,0.031024007,-0.09903585,-0.020109067,-0.007879369,-0.0038845623,-0.082174435,-0.053559184,0.017158164,0.035645667,-0.03894398,0.07220233,-0.090308815,-0.06682864,0.07026584,0.012287801,0.0060190344,0.027008729,0.03987808,0.010195451,0.014891115,0.12697074,-0.013842246,-0.016734514,0.0032405653,-0.0023656397,-0.021559477,-0.03670832,-0.14109224,0.04891103,-0.037364956,0.07416916,-0.037068248,-0.09349372,0.062040407,0.052712947,0.016427938,-0.008150984,-0.008405951,-0.020284155,0.043422177,0.020995393,-0.03189475,0.0112463385,-0.08831968,0.07836942,0.06995346,-0.023181777,0.065540686,-0.006462384,-0.058219846,0.03668311,0.02496321,-0.0367766,0.03016946,0.06506995,0.030398607,0.05913342,-0.026137754,0.03091843,0.043464843,0.041971367,-0.08874533,-0.035432015,-0.017965268,0.08432517,0.009017698,-0.025496438,0.08310788,0.06374732,-0.097012825,-0.042711504,-0.107253484,0.02427165,-0.008291361,0.048242982,-0.03613418,-0.004428979,0.016958835,-0.007083549,-0.08165581,-0.0073724305,0.05260426,-0.088633716,-0.012505814,-0.04491295,-0.00017580499,0.018754663,0.021381736,0.065870225,-0.049383637,-5.256806e-33,0.11317693,-0.10927138,0.037549175,5.301684e-05,-0.019452067,-0.03989362,0.022297975,-0.052537393,0.039179828,0.04964952,0.08550767,0.026647504,-0.034042995,-0.015835961,0.050740976,-0.040859193,-0.073226705,0.045862537,-0.069295086,0.03363259,0.03301086,0.003149989,-0.027395925,0.01260618,0.017714214,-0.00027621532,0.03836666,-0.019186413,0.0015996654,0.018168649,-0.0481825,0.0535637,0.04231567,-0.099446,0.008875442,0.014688319,-0.020242449,0.03666839,-0.05527677,-0.058436032,-0.040909342,0.1535566,0.009600102,0.076904275,0.11220886,0.15385231,-0.015167614,-0.047351215,-0.042058617,-0.10786237,0.05664053,-0.03964228,0.07633002,0.019779317,0.012929878,0.02163048,0.038388364,0.004299032,0.018105457,0.0113262925,-0.0404343,-0.0063499305,-0.022218615,-0.060108703,0.07669613,-0.002098934,0.029197529,0.003693271,0.0149542065,0.02086392,-0.0068743736,-0.08271196,0.069470085,0.05208565,-0.0201753,0.020300811,-0.10691397,0.0008343064,-0.00923494,-0.06554869,0.03853915,-0.027731108,-0.012641082,0.029354775,-0.0002648357,-0.107224144,0.0066112406,0.16744438,0.017123407,0.023073273,-0.09321835,0.015234607,-0.005547144,0.023555456,0.006140612,-3.616238e-08,0.025452007,0.00031207583,-0.049841143,-0.031841982,-0.040405307,0.044306215,-0.01252605,0.033942323,0.027436193,-0.027493212,-0.004129411,0.0772799,-0.07159606,-0.02821935,-0.032480814,0.06487026,-0.0881986,-0.03321765,0.015405995,-0.053377427,-0.10288424,0.029024413,-0.03663176,-0.003810915,-0.025843892,-0.06951852,0.0035896634,0.057296645,0.0020646316,-0.041498665,0.0060643693,0.04377552,0.045069527,-0.027166616,-0.05958249,0.0089854095,-0.002461371,-0.029806156,0.11697853,0.008354991,-0.026507856,0.007145343,-0.039597332,-0.0419509,-0.03197328,-0.006404748,0.052753013,-0.031305976,-0.0386165,0.029265055,-0.00015205194,-0.012058085,-0.019913152,-0.028401263,-0.05803209,-0.02258614,-0.07033866,-0.09823782,0.07013991,-0.085312866,0.02825786,-0.025204875,0.06912796,-0.02826293 +2.1.1.299,"This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.",384,0.99999994,-0.024663014,-0.02672686,-0.090024345,-0.028282233,0.088105306,0.06745464,-0.06715043,0.0753677,0.055812247,-0.075600654,0.055044834,-0.06324376,-0.028314402,-0.01827515,0.033789165,0.055872083,-0.122907326,-0.051225595,0.033330426,-0.025252083,0.08802285,0.07271157,-0.031095972,-0.036126345,-0.0019761364,-0.012741911,0.02664353,0.023204874,0.095674485,-0.049781762,-0.005346621,-0.023923313,-0.0064158197,0.0074562724,0.04804068,0.05754394,0.0037339665,-0.014160555,-0.0015019065,0.032746848,0.12109107,0.0073031746,0.0025044817,-0.0973089,0.00031507172,-0.043550976,0.0054213866,0.012565357,-0.016701868,-0.0042304313,-0.020503743,-0.10322844,0.013139726,0.056792203,-0.01677824,0.012602951,-0.0431032,-0.020235123,0.027693627,-0.023461828,0.0073714126,0.033285454,-0.02250568,-0.04971009,0.10204225,-0.098333016,0.053799372,-0.08287852,0.027463507,-0.00094576617,-0.086560294,-0.08225593,-0.016747111,0.059723407,0.001500801,-0.008485097,-0.010721435,-0.006988979,0.058961235,-0.04809105,0.022700017,0.038983624,-0.0035037142,0.010669957,0.02706681,-0.0049980856,-0.035730284,0.051011737,0.0510398,0.0047469144,-0.04419274,-0.09401949,0.0028708058,-0.0036402026,-0.0994823,0.032752905,0.0063408683,0.07661165,-0.008298192,0.054668017,0.0070474567,0.072543554,-0.11489554,-0.044488337,-0.06454237,0.007353569,0.044128243,0.083842404,-0.016708786,-0.0414874,0.057172284,-0.050257307,0.08750249,0.005704125,-0.03656864,0.086235315,-0.056623958,-0.051368423,0.034981403,-0.032219112,0.0006325907,-0.033524923,0.057522804,0.03521992,-0.020444995,0.06811263,-0.12140359,-8.917885e-34,0.10404487,0.012483903,0.035081267,-0.040764064,0.013953536,-0.032428104,-0.092912205,0.0357192,-0.0116121285,-0.1125606,-0.053469747,-0.07704721,0.019567834,0.047286645,-0.045770206,-0.053917732,0.024502316,0.020398501,0.014954861,-0.010298763,-0.018463088,-0.0009189864,-0.019840475,-0.03138824,0.019122615,0.035042923,0.008666561,0.0052808453,0.039312866,0.035929073,-0.05485755,-0.039193053,-0.045163177,0.047441244,0.052819002,0.020906914,0.016607326,-0.039755825,0.0441808,0.06428127,0.045154613,0.04013064,-0.020737609,0.0035885528,0.0072355126,-0.056758076,-0.0643778,0.024361767,0.0019704856,0.0484602,0.0279419,-0.07272572,0.06720986,-0.051670413,-0.10287964,-0.0082333395,-0.09816928,-0.05547798,-0.020678671,0.09517978,-0.028816395,-0.02610828,0.00929721,0.095487386,-0.011435032,-0.046154495,-0.04555226,-0.041053053,0.02285412,0.0719006,-0.056113712,-0.029089317,0.13799894,0.03813974,0.017724534,-0.043441202,-0.105178855,0.045066845,0.024121333,0.07067127,0.010274023,0.04817319,-0.062701836,-0.07718921,-0.04110841,-0.026306286,0.049098134,-0.09859528,-0.016184758,-0.0131397825,-0.013781072,-0.0558019,-0.0060982215,0.06463056,-0.0071532633,-8.622129e-34,0.012932864,-0.018794324,0.07106132,-0.09735977,-0.05500213,0.021086918,0.06393547,-0.06276315,-0.023338716,-0.0407011,0.10655572,-0.0020249858,0.065072626,-0.034884684,0.054235447,-0.012559059,-0.02562704,0.05488114,0.035800677,-0.03216908,0.08451197,-0.033568308,-0.03432546,0.05953767,0.040869366,-0.013381899,0.0015874178,0.0952703,0.061325297,0.052653737,-0.028340874,0.018728603,-0.040685933,-0.024542822,-0.019902393,0.09278019,-0.005119741,-0.012018519,-0.0069756247,-0.03414284,0.053014167,0.047298275,-0.006838729,0.056889996,0.037488557,0.06862499,-0.013911108,-0.0408251,0.015603095,-0.08686232,0.028362188,-0.029664965,0.045669593,0.02585019,-0.039019283,0.06656117,-0.009169082,0.07062085,-0.041081026,0.0021172422,-0.029582687,-0.014550184,-0.028066002,0.030858336,0.04876068,-0.0118990885,-0.0023393387,-0.011321897,0.008017897,-0.0052535934,0.049648512,0.019043753,0.014132348,0.052733038,-0.07300231,-0.074246794,-0.11553945,-0.06665461,-0.0536348,-0.069007695,-0.048358567,-0.06787756,-0.017989047,-0.076603435,0.001088347,0.026408197,0.03596318,0.11113502,-0.04006715,0.06522575,-0.08086112,-0.021974143,-0.08193288,0.03150055,-0.028507218,-3.8901426e-08,0.048537325,-0.13381228,0.009185279,0.0005955452,-0.02973425,0.054800767,-0.04939438,-0.04207809,0.032136835,0.02478294,0.0037688937,0.050090224,-0.018292107,0.009789706,0.004962316,0.07147559,0.050642923,0.082210235,-0.008655632,0.0059603807,-0.02336531,0.026352787,-0.018226957,-0.0032452692,0.0007174667,-0.02026623,0.015883168,0.16561846,0.0048498637,-0.065234154,0.024565764,0.00094303355,0.017068181,0.0049178787,-0.042913012,0.020082155,-0.008832753,-0.05979298,-0.010062199,0.07583885,0.098826244,0.017715508,-0.05278701,0.008097799,0.026572186,0.021139063,0.0069058486,0.043512408,-0.060257223,0.01761289,0.04080842,-0.06367744,0.001095985,-0.074943796,-0.07411114,-0.020938715,-0.058391634,-0.021195536,0.036847793,0.017833658,0.05543805,0.064822875,0.15577492,-0.06822392 +2.1.1.300,"The enzyme, isolated from the plant Thalictrum flavum, also methylates (R,S)-stylopine and (S)-scoulerine (11%) with lower activity (14% and 11%, respectively).",384,1.0,0.0139387,-0.08373993,-0.19772166,0.057957105,0.12079255,0.16851349,-0.103105344,0.06965259,0.019562457,-0.05530602,0.012373745,0.025732486,-0.040223125,-0.051923666,-0.0123140495,0.040511794,-0.031037373,-0.0020517937,-0.029414605,-0.035862055,0.026335431,0.010172789,0.008650538,-0.002531165,0.04159394,0.02716286,-0.041425925,-0.05769114,0.009909254,-0.013737062,0.021172522,0.025388708,0.08158558,-0.05113462,0.0013419043,0.036062997,-0.037010774,-0.031206757,0.059565127,-0.005082334,0.04546936,0.021286951,-0.010185305,-0.057032764,-0.05642948,0.0021574995,-0.0046265074,0.035686765,-0.0414034,0.0041564093,-0.030021299,-0.08046038,-0.047742598,0.048703767,-0.04223834,0.018828245,-0.00852752,-0.047273554,-0.015487329,0.0066673034,0.080100685,-0.007120686,0.05545633,-0.015649853,-0.013603207,-0.036009677,-0.01751065,-0.0025952181,0.10471265,-0.020790303,-0.027349781,-0.04486155,-0.03210645,0.034176502,-0.044373844,-0.008359565,0.022461308,0.043092795,0.057543565,-0.00317694,0.035133682,-0.023718033,0.037267577,0.05548827,0.035408553,-0.010200369,-0.07775475,0.096766904,0.103586726,0.039092343,0.07293552,0.034086574,-0.059832502,-0.02751708,-0.06187597,0.00948726,-0.00804597,-0.021086257,-0.06878251,-0.03236632,0.01942009,-0.019331839,-0.002868483,-0.07544492,-0.032099668,0.05457619,-0.02730155,-0.02764957,0.003584738,-0.023806855,-0.039847694,-0.02053839,0.016042253,-0.02303726,0.030205691,-0.0031258995,0.04250222,-0.040242396,-0.035011612,0.0054149325,0.018143814,0.044518474,0.11174288,0.033632196,0.017796168,-0.038050577,-0.1997488,-1.17819615e-33,0.058978193,0.058236513,-0.024130737,-0.057438698,0.07095253,-0.04081466,0.0086713685,0.10452531,-0.00704569,0.0008706388,-0.103183866,-0.0871248,0.026593475,-0.042199396,-0.020683507,0.019535717,0.004337146,-0.058343593,0.04664499,-0.09365672,-0.012504332,0.049419537,-0.048124418,0.058553096,0.011835369,-0.011680806,0.03228637,0.021580039,0.05436415,-0.04224348,0.0052701705,-0.12686346,-0.051201537,0.016986942,0.07764118,0.058031153,-0.07023796,-0.02680419,-0.053662103,0.08765258,0.022611825,0.003682169,0.013449815,-0.022701312,0.0067335945,-0.010777222,-0.08941524,0.037186015,0.12036282,0.01497563,0.03552458,-0.049614057,0.07540816,0.049912773,-0.07405867,0.017459378,-0.031305544,0.06112377,0.046164792,0.056774963,-0.05997165,-0.057613198,0.015174214,0.009544001,0.030584864,0.05334699,-0.112031184,-0.0758591,-0.032206908,0.039933536,-0.0044067698,-0.034404352,0.08731539,-0.04039678,0.07956536,-0.03004366,-0.03398277,-0.0054078074,0.036780495,0.06734697,-0.016312072,-0.011504106,-0.000832423,0.015956324,-0.09799295,-0.0419931,-0.032719906,0.027264412,0.018740803,0.033090513,-0.0006123769,-0.12054395,-0.029973168,0.025958456,0.027947932,-3.1415727e-34,-0.0021085513,-0.03889239,0.054135192,-0.009014009,0.0033217196,0.13170394,0.04307145,-0.040974017,-0.006628974,0.0047754017,0.08447201,-0.016706958,0.005308926,-0.011244418,0.0468783,0.05144587,0.04546745,0.11377851,0.01893128,0.0018124449,-0.08681569,0.03533653,-0.015186496,0.025097163,0.02981904,-0.014693064,0.020240618,0.008836335,0.0619224,0.021041807,0.009902488,-0.01585879,-0.07874795,-0.06384122,-0.05424546,0.05357642,-0.10282369,-0.009614167,-0.0617635,0.062788665,0.04406104,0.021318546,0.03669133,0.12576102,0.05152069,0.023361113,-0.11886862,-0.026985409,-0.030893046,-0.0014161636,0.03760775,-0.012214735,-0.047667384,0.06571705,0.068297796,0.02066395,0.010238468,0.02381064,-0.072492704,-0.022914914,0.0017397278,-0.07084852,-0.10563375,-0.006085397,0.084211044,0.05568847,-0.0033479212,0.06175717,0.03503143,-0.033281907,0.102455154,0.0006485575,0.023827922,0.07674427,-0.022343526,-0.036234412,-0.0529202,0.0027704353,-0.023439508,-0.025050418,0.053804416,-0.058707245,0.01815786,-0.07457054,-0.04980284,-0.05179415,0.015224683,0.07271837,0.07526111,0.025997777,-0.035278574,-0.018562827,-0.038198285,0.0386648,0.081378065,-3.4797907e-08,0.00019426634,-0.10855722,-0.021520287,-0.017952735,0.01354055,0.037109993,-0.0109886555,-0.049766336,-0.04030643,0.037646476,-0.033503022,-0.017048832,-0.010863077,-0.00033261962,0.018206814,-0.047293603,-0.011798054,0.08925626,0.033350468,0.015181161,-0.020915687,0.028410748,-0.0768386,-0.007447641,0.0057123555,-0.027770149,0.029987212,0.047094963,0.057134904,-0.03921862,0.038873054,0.020031294,0.056961443,0.015163819,-0.104789734,0.007230724,0.013976569,-0.019798614,-0.022134565,0.082820155,-0.022375477,0.018936722,-0.03072674,0.0050006304,-0.03483895,-0.030401273,0.0013375093,0.02425761,0.019138912,-0.071751826,-0.009197699,0.027536927,-0.069323055,-0.04217652,-0.038410846,-0.009859203,0.0118104555,-0.057332322,-0.09761625,-0.073566355,-0.023731878,-0.015003561,0.13112095,-0.0057631093 +2.3.1.232,"The enzyme from Concord grape (Vitis labrusca) is solely responsible for the production of O-methyl anthranilate, an important aroma and flavor compound in the grape. The enzyme has a broad substrate specificity, and can use a range of alcohols with substantial activity, the best being butanol, benzyl alcohol, iso-pentanol, octanol and 2-propanol. It can use benzoyl-CoA and acetyl-CoA as acyl donors with lower efficiency. In addition to O-methyl anthranilate, the enzyme might be responsible for the production of ethyl butanoate, methyl-3-hydroxy butanoate and ethyl-3-hydroxy butanoate, which are present in large quantities in the grapes. Also catalyses EC 2.3.1.196, benzyl alcohol O-benzoyltransferase.",384,1.0,-0.011408975,-0.010028492,-0.07936937,-0.00067980954,0.0785476,0.07724889,-0.09538312,0.009593977,0.03544309,-0.020444628,0.0055443184,-0.023096977,-0.064943954,0.0137293115,-0.088200025,0.061207015,-0.015550677,0.009679006,0.027495977,-0.04802111,0.08501255,-0.030967826,0.048702408,-0.013707523,0.057328917,-0.028612921,-0.025240848,0.052195996,0.015572656,-0.12653735,-0.022797456,-0.06455992,0.01991888,-0.07195991,-0.015841298,-0.06593977,0.052981455,-0.08860158,0.06899939,0.064597435,0.009003126,0.036875937,-0.07463231,0.03732693,-0.038911182,-0.01297343,0.057145778,0.003879086,0.01729322,-0.032714915,-0.039601903,0.0019124448,-0.039253257,-0.07913147,-0.065015756,-0.0852259,-0.008122389,-0.0157065,-0.011493136,0.06549508,0.060144026,0.0144741805,-0.023763368,0.015028185,-0.058194824,-0.041023813,-0.0048266607,0.04974531,0.016576936,0.0047400263,-0.07856437,-0.044400558,-0.030895893,0.04196368,0.0074848346,0.0697326,0.069913395,-0.023641424,0.029023234,0.01958527,-0.026725201,0.003282665,-0.071300805,0.0983026,0.0047665173,0.03653656,-0.029804993,0.032717083,0.069669284,0.06110781,-0.004614937,-0.06439525,-0.048131753,-0.10148318,-0.0063812416,0.048422743,0.07912139,0.0018682719,0.07257019,-0.011300953,-0.07044101,0.055041336,-0.00027304346,-0.08324025,-0.081999615,0.053171948,-0.08632508,0.062841855,0.068625264,0.02688419,-0.01645363,0.017167106,0.00177185,0.02980467,-0.042056274,0.12575349,0.0004249259,-0.0863067,-0.044977874,0.009899745,-0.00034199597,-0.019361211,0.06839348,0.13933487,-0.03898083,0.06125075,-0.04183352,5.022241e-34,0.0019398895,0.019182744,-0.067341186,-0.0071492414,0.0005572159,0.028865522,-0.055974275,0.03975522,-0.08560137,-0.059578937,-0.077471375,-0.039823655,0.061287086,0.02393689,-0.0010661634,-0.03129895,0.11087749,-0.01620404,-0.044736408,-0.020419026,0.039210036,-0.04775926,-0.035520073,0.059915133,-0.014869183,0.040209837,0.02285084,0.066710666,0.0188866,-0.04689247,-0.007372789,-0.04532689,0.00499774,0.016028296,0.055037376,0.03991896,-0.06003311,-0.027246322,0.0540344,0.049533915,0.068142325,0.11288109,0.057035435,0.053101633,-0.0042222645,-0.005332192,-0.08288707,0.10412515,0.025620747,0.010328997,-0.031695127,0.03357487,0.09519583,0.0023849446,-0.01699681,0.073474504,-0.0024570196,-0.002840763,-0.03986921,-0.032906055,-0.019000303,0.019992251,0.014970679,0.062185265,-0.023562802,0.0056323186,-0.053946376,-0.014756913,-0.0010909208,0.06308711,-0.08297184,0.016133657,0.062164787,-0.024943989,0.025688894,-0.027321516,-0.08500273,-0.014017029,0.05235411,0.017508475,-0.06480638,-0.06968615,0.004607793,-0.052653614,-0.041007385,-0.01759985,-0.048725758,-0.0061180065,0.028744023,0.10112217,0.028726472,-0.056603175,0.013462564,0.0028516315,0.02825517,-2.2845086e-33,0.06229427,-0.060066372,0.06398615,-0.12042743,-0.035595775,0.09785608,0.017249608,-0.05536719,-0.054079,-0.05755584,-0.0113532655,-0.032960244,0.040538754,-0.04248343,-0.014470344,0.030549694,0.03916135,0.108589925,-0.0155593455,-0.015164901,-0.047980458,0.10289339,0.015268874,0.0018012837,0.07001424,-0.04999533,-0.022837592,0.009701434,-0.0115905,0.014946585,0.025074113,-0.033267565,-0.008746073,-0.052645065,0.024241962,0.072212525,-0.013380573,-0.033980116,0.022595784,0.085007444,0.0103948815,0.029261854,-0.11623119,0.04485441,0.024113618,0.09906285,-0.11235993,-0.0027937042,0.009876573,-0.056924127,0.048780777,-0.023234097,-0.034255568,0.08480388,0.03435104,0.07517591,0.004683622,-0.007993103,-0.042860467,-0.042960256,0.012984022,-0.033040646,-0.023553636,-0.083878696,0.00081812765,0.018616239,0.00017226319,0.034366194,0.001036882,-0.023874033,0.082809635,-0.009842642,0.005086251,0.08642002,-0.03929095,-0.07535565,-0.07486512,-0.094674945,-0.07787733,-0.05098708,-0.022264458,-0.0013748539,-0.020067997,0.049506713,0.0012927639,0.021983357,0.023525935,0.10247211,-0.0051480685,0.08319801,0.0037465403,0.026930748,-0.047548264,0.052786563,0.053843047,-4.3700524e-08,0.040465962,-0.07369993,0.016635904,0.0039837016,-0.059855666,0.034857944,0.024230914,0.0185049,0.0088976035,0.0018008099,-0.03846903,0.042405583,0.012605154,-0.013720203,0.026287727,-0.02390279,0.04746716,0.076162525,-0.031401113,0.012953733,-0.081161,0.035972703,-0.06369014,0.029187243,-0.009921324,-0.090682246,0.010130045,0.035194933,0.057647664,-0.04854211,-0.038235914,0.011638998,0.0048982385,0.00020442433,-0.0853744,0.039784398,0.025737308,-0.013699232,0.008499457,0.08232792,0.036178574,-0.06363432,-0.090236865,0.037835494,0.012584981,0.030966131,-0.0085075945,-0.017850183,-0.004797846,0.009735672,0.04919424,0.031094108,0.04653419,-0.046657395,-0.100891694,-0.011857022,-0.0484512,-0.05188044,-0.020377522,-0.03610285,0.052612025,-0.040620744,0.21813574,-0.08755176 +2.4.1.315,"The enzyme is found in several bacterial species. The enzyme from Bacillus subtilis is specific for glucose [1]. The enzyme from Mycoplasma genitalium can incoporate galactose with similar efficiency, but forms mainly 1,2-diacyl-diglucopyranosyl-sn-glycerol in vivo [3]. The enzyme from Staphylococcus aureus can also form glucosyl-glycero-3-phospho-(1'-sn-glycerol) [2].",384,1.0,-0.011411816,-0.02391526,-0.113138445,0.025043063,-0.025273195,-0.016930772,-0.022349343,0.06408103,-0.01842932,-0.029822953,0.017610885,0.01659463,0.009773905,0.08857773,-0.090911314,-0.0057577146,0.043359857,-0.019856246,0.027501078,-0.032727018,0.15013681,0.05603167,0.00050612487,-0.030975033,0.09017729,-0.08475935,0.030987699,-0.0413364,-0.053355757,-0.05599855,-0.0061841467,-0.08528768,0.061369922,0.0016193324,0.05198872,0.0512245,-0.036759734,-0.0068110637,0.0943567,-0.007388042,-0.0073110615,-0.031671133,0.018826876,-0.036903918,0.010736567,0.013819771,-0.024415541,0.005344249,0.041230835,0.05153705,-0.005612888,-0.051845826,-0.04514262,0.02231996,0.09973998,0.0052463682,-0.069878876,-0.033115678,0.0044505666,0.040105637,0.035977658,-0.0017959267,0.01879111,0.014925298,-0.031246893,-0.060982686,0.038339198,-0.06911494,0.02656424,0.010200683,0.0035894176,-0.012966733,0.001331388,0.052159682,-0.0010811534,0.02074363,-0.008349503,0.01140851,0.07088077,0.0014902366,0.031275526,0.0059532383,-0.007275906,0.070088685,-0.042594533,-3.8164868e-05,0.13039535,-0.006186894,0.021326153,-0.0035327657,-0.007023782,-0.053063706,-0.049288306,-0.055023998,-0.010120779,-0.039321095,0.009725268,-0.059317697,0.015937813,-0.0827714,0.013045537,-0.02507916,0.0671857,-0.037609436,-0.07828474,0.06836911,-0.0007443346,0.011735119,0.09504648,0.028472347,0.0007812837,0.13477798,0.048284113,-0.00020076011,-0.031728044,0.072543666,0.056474537,-0.055063784,-0.055058148,0.017435974,-0.023808874,-0.065046504,0.059495278,-0.0042450144,-0.051468816,0.06742514,-0.019376848,2.9843294e-33,0.014345708,0.016651107,0.018208604,-0.033281166,0.07629497,-0.031488758,-0.08232564,-0.0073499787,-0.073805846,-0.016079808,-0.071625,-0.035372294,-0.004382647,0.11426342,-0.07392239,0.08291667,0.11662523,0.0022429482,0.029654592,-0.031013777,-0.0022888111,0.03397959,0.024851989,-0.049336623,0.058006864,0.0862841,0.041728724,0.016121136,0.11088278,-0.0004580919,0.06562126,-0.09297748,-0.03632676,0.0013668409,0.09476846,0.079518996,-0.045826472,-0.019204354,0.023047585,0.019018656,0.014167659,0.0066264435,0.04579221,-0.04437546,0.022164363,-0.018742036,-0.08886332,0.037603043,0.0044062342,0.059145365,0.02984964,-0.019284701,0.015187235,0.024014488,-0.0051429365,0.03687641,0.0268532,0.02522939,0.05162118,0.03162382,-0.011484722,0.07377968,-0.049814336,0.033983152,0.0052564414,0.012727109,-0.03973615,0.02597433,-0.07283148,0.027215686,-0.051267203,-0.029688884,0.007476048,0.009137386,-0.03696289,-0.05661103,0.016774848,-0.011258718,0.014113009,-0.054394603,-0.038518947,0.04630342,-0.0046988055,-0.08581143,-0.055652898,-0.010588324,-0.0774431,-0.07476926,-0.030996738,0.018913563,-0.019906458,-0.038143113,-0.0483187,0.031987503,-0.058908727,-4.869493e-33,0.10659504,-0.17009096,0.111846365,-0.07995305,-0.03491601,0.055440284,0.02447279,-0.0119019,0.012532054,0.03557236,0.0033356473,0.03967982,0.042015877,-0.048508484,0.020539561,0.049745332,-0.008205047,0.0658492,-0.054951876,-0.0372759,-0.041169245,0.13684618,0.008896958,-0.048372276,0.043896705,-0.03363057,0.0068292883,0.10287372,-0.033584364,-0.018223733,0.0045358697,-0.048909903,-0.05039092,-0.10701202,-0.037643872,0.0069683753,-0.02782738,-0.01864033,0.025561843,-0.04058577,-0.035053022,0.093597695,0.016511237,0.01545036,0.0690038,0.060786247,-0.075421534,0.0017790722,0.0369759,-0.013910398,-0.020948045,-0.034836713,-0.022830652,-0.0028114368,0.059053473,0.029011674,-0.00019403764,0.013762583,-0.060929336,-0.04267722,-0.053326793,-0.100750335,0.039880995,0.016717069,0.0631193,0.09190181,-0.017303275,-0.01334485,0.020472424,-0.019339317,0.0020038488,-0.052880947,-0.06597855,0.050594468,-0.04019892,-0.0040110424,-0.0896523,0.0022132308,0.005630877,-0.06156739,0.071104,0.007885613,0.005578288,-0.07527888,0.011979252,-0.094782606,0.045121185,0.13163741,0.017109528,0.023949185,-0.047336556,0.0674111,-0.04643429,-0.060740564,0.06648849,-4.039625e-08,0.042118333,-0.026927881,0.044512354,-0.064330176,-0.008332531,-0.018051302,-0.023998234,-0.0076492885,0.014182243,-0.09044053,-0.08802325,0.037199605,-0.04126117,-0.05618486,-0.022903023,0.018779438,-0.059835378,-0.008463823,0.0008929059,0.014211257,-0.050026402,0.0023133548,-0.10296979,0.09674546,-0.0004849877,-0.021221682,0.0720583,0.072606385,-0.08947478,0.0093168495,-0.024064086,0.05777381,-0.043204065,-0.028977484,-0.09328665,-0.03036247,-0.03677703,0.01714337,0.033073682,0.015213556,0.09932327,-0.02451254,0.066295266,0.0008026064,-0.1026336,0.053342104,-0.0010077698,-0.027654085,-0.0011508482,0.10109265,-0.030601194,-0.025202576,-0.044688918,-0.034163125,-0.07632572,-0.024497729,-0.008299469,-0.045453936,-0.03860057,-0.02839738,0.017462203,-0.01386588,0.19152947,0.014410624 +2.4.1.316,"The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene.",384,0.99999994,-0.0023991454,-0.03178237,-0.1087834,-0.02354302,0.0009101186,0.04471965,-0.045864116,0.0415398,0.09026039,-0.011509737,-0.0032491551,-0.01372496,0.027407933,0.08500974,-0.026876336,-0.011970287,-0.06666849,0.013394628,0.0067148,-0.07741623,0.046573807,0.07791023,0.074426204,0.015753986,0.00073124113,-0.060622476,-0.007491288,0.0056714835,-0.038326517,-0.0482468,-0.030095741,-0.05328178,0.079715975,-0.068703756,0.082094684,0.05639813,-0.019892924,-0.028681243,0.11726321,-0.029854918,0.0076751746,-0.07152971,0.0055110706,0.00844296,0.003819338,0.02413776,0.05913544,0.020420853,0.098640196,0.027645763,-0.073680975,-0.033011198,0.0038640972,0.052156165,0.058942225,0.04621392,-0.0061427443,-0.02683656,-0.017522119,-0.07454018,0.046175778,-0.029899843,0.031649422,-0.025824582,-0.073556155,-0.05408806,0.019192742,-0.058102556,-0.01240032,-0.027667416,-0.039475027,-0.05655256,0.029399827,0.03885152,0.004855759,0.043544408,0.0076882765,-0.014580489,-0.05693006,-0.015035373,0.06579523,-0.03670669,-0.019131329,0.13338909,0.023913927,-0.06992546,0.020141846,-0.010852543,0.039558794,0.08107117,0.02566494,-0.05544261,-0.012875681,-0.043783672,-0.053498536,-0.044773668,-0.08631797,-0.03431431,0.045581587,-0.0034237104,-0.07021586,0.030758696,0.073796935,0.01923665,0.014842854,0.0511182,-0.020000324,0.065310374,0.051421132,-0.06173288,0.04500151,-0.018597726,0.06719166,0.009898739,-0.038750667,0.033258747,0.06328453,-0.016414493,-0.012898871,-0.010266717,0.064008996,0.0050712917,0.0485477,0.022058472,0.0052895593,-0.012563959,-0.061545275,-7.294071e-34,0.05095016,0.05617091,-0.028535087,0.013815273,0.032032896,-0.034062825,-0.08637103,-0.03762264,-0.04661541,-0.010809627,-0.101948224,-0.14598194,0.058126055,0.09497578,-0.006185473,0.0057585174,-0.017075751,0.03501136,-0.024926577,0.030757504,0.01199343,0.057446998,-0.072861984,0.024100289,0.06489496,0.11121536,0.023161648,0.029206518,0.031532653,-0.03934115,0.045305222,-0.02367559,-0.049569674,0.0334882,0.10406266,-0.0048214197,-0.0036062559,-0.041476715,0.06967683,0.028780535,-0.023979815,0.036691643,-0.023774793,-0.06721521,0.033310283,-0.04249517,0.017177362,0.068550594,0.07018008,0.043613333,0.12821074,-0.06777981,0.048278414,0.01928339,-0.027678294,0.016956905,-0.03051414,0.07920781,0.11400308,0.018567853,-0.03912602,-0.051194772,0.011230926,0.025436427,0.03979928,0.01360366,0.005241402,-0.012856829,-0.015724888,0.03014412,-0.050104182,0.03331051,-0.005627216,0.024098191,-0.02619362,0.037637804,-0.07469865,-0.027775463,0.124986336,-0.015515695,-0.054840926,-0.054212198,-0.021281794,-0.029654495,-0.066167824,0.09566805,-0.026736304,-0.0868749,-0.019992877,-0.02864219,-0.011737699,-0.10176838,-0.08333949,0.045283332,-0.028760688,-1.9024504e-33,0.07991539,-0.07175586,0.060304556,-0.09228523,-0.11678653,0.051028308,-0.08788959,-0.0357294,-0.056341685,-0.01618092,0.06634252,-0.030823616,-0.033593293,-0.031505242,-0.00717709,-0.057050996,0.016052406,0.029490007,-0.080210425,-0.010552511,-0.02002287,0.014771484,0.012661287,-0.016394923,0.036534403,0.038606703,-0.053209864,0.11026477,-0.011346874,0.07979519,-0.044769622,-0.046051186,-0.012418536,-0.05253536,0.006751196,0.14547886,-0.044056423,-0.009134379,0.06558685,-0.032287616,0.089093566,0.012052116,0.0042866655,0.046319164,-0.011477704,0.08283331,-0.05943457,0.024612367,0.050759394,-0.05352777,0.01863319,0.046491254,0.08439104,-0.066331245,-0.026741039,0.019518707,0.06879921,-0.06946175,-0.013870375,-0.017026762,-0.003324068,-0.01562618,0.12213406,0.03214889,0.023184987,0.051399942,-0.05587744,0.059850067,0.09984633,-0.04360879,-0.012739803,0.021832205,0.041223146,0.02704836,-0.002297869,-0.02717342,-0.09073073,-0.021168692,0.052391168,0.02657324,-0.037081517,-0.016922874,0.0034699964,-0.06046791,-0.03686954,-0.009551736,-0.013522795,0.045735598,0.016775426,0.009915251,-0.022115132,0.047158513,-0.036173142,0.014912832,-0.026179371,-3.060632e-08,0.09764278,-0.0059148637,0.044438187,-0.06254354,-0.0426357,-0.002864846,-0.09209054,-0.00015925798,-0.010369451,-0.03868325,-0.003607723,0.02467091,-0.061440717,-0.041599352,-0.0056672404,-0.0022628277,-0.08610438,-0.046414204,-0.044215433,-0.06454359,-0.049227286,-0.0025425775,-0.06533063,0.019993514,0.09480504,-0.065392144,-0.028286941,0.019348087,-0.022190617,-0.024240097,0.028746877,0.007816712,-0.04758135,0.023478026,-0.04502977,0.0025321834,-0.07722122,-0.06981666,0.015096996,0.011377304,0.027688542,0.024731705,-0.09751735,-0.02133784,-0.076233104,0.040070023,-0.021402918,-0.032938547,-0.071739085,-0.017621914,0.07950594,0.034175646,0.024200773,0.07151441,-0.12764862,0.047064945,0.002580397,-0.010196477,-0.01243619,-0.026063329,-0.031545836,-0.08294511,0.1516364,-0.047123294 +2.4.1.317,"The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. 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+2.4.1.319,"The enzyme, isolated from the ruminal bacterium Ruminococcus albus, catalyses the reversible phosphorolysis of beta-1,4-mannooligosaccharide with a minimum size of three monomers.",384,1.0,0.03191719,-0.041434694,-0.04863589,0.019454425,0.012679593,0.034709863,-0.0023845534,-0.032694187,0.042899847,0.08623794,0.02872607,-0.021841696,-0.13325366,0.08310732,-0.07309521,0.00678817,-0.05500597,-0.023147639,0.043430272,0.013789839,0.11188536,-0.01953118,-0.026686722,0.082200326,0.08893241,-0.024723642,-0.014928095,-0.042156328,-0.025450839,-0.07263994,0.0041981987,-0.06355119,0.06326017,-0.046676606,0.03945684,0.0037621208,0.06973435,-0.030660955,0.13692634,0.023747813,0.0036797572,-0.022804588,0.0232762,-0.030280787,-0.05586379,0.027302118,-0.031625632,0.09645967,0.11262338,-0.008286799,-0.03249861,-0.029432276,-0.044662908,0.039142687,0.019735973,0.026757415,-0.007217393,-0.02747855,0.046850357,0.047382988,0.024262978,0.030738572,0.02080098,0.044499643,-0.02948514,-0.04955793,0.0026466898,-0.058213994,0.0113693215,0.047278482,-0.05058726,-0.094402626,-0.022370115,-0.02185417,0.07380459,0.003759873,-0.011293686,-0.037248015,0.030597182,0.012801515,0.04303784,0.035354223,0.005583108,0.020289518,-0.01785384,-0.031983554,-0.003122161,0.019224614,0.080814615,-0.03491819,-0.0053151525,-0.053488504,0.03425106,-0.058680456,-0.009728133,-0.044800483,-0.022038657,0.02718563,0.08183482,0.004499955,0.0316441,0.030422227,0.06588781,-0.16511686,-0.04932004,0.109823376,-0.033581693,0.08246618,0.052674398,-0.0013802757,-0.036464304,0.032357346,0.011755838,-0.0059953965,-0.064606495,0.04188821,0.0015694064,-0.106098585,-0.13063739,0.048453026,0.043248035,-0.04267726,0.098490916,0.02480455,-0.035989095,0.050736833,-0.07966524,2.1444385e-33,0.032922845,0.003631842,0.039813995,-0.061182316,0.082427934,-0.015149884,-0.0461196,-0.039627414,-0.06326933,0.0004389449,-0.00696874,-0.04990678,-0.015511349,0.07449549,-0.026155813,0.008921891,0.013186448,0.0027734514,0.014585365,-0.0458229,-0.05821788,0.052550633,-0.048393965,-0.026034188,0.063300654,0.06174822,-0.006420811,0.02273789,0.077565804,0.029201686,0.08435792,-0.06071593,-0.119014695,-0.046528388,0.04948219,-0.037081536,-0.077552795,-0.063544326,0.03874709,0.0023246221,0.0029007352,0.029008456,-0.014680721,0.0025050761,0.028654644,-0.03520949,-0.05559771,0.070186645,-0.016709682,0.035503317,-0.00078295416,-0.013396256,0.0026537224,0.022731336,-0.043053027,0.022427365,-0.03757966,-0.077747956,0.023583315,0.04030962,-0.020901432,0.07791937,-0.08785956,-0.031228129,-0.06358389,-0.01653146,0.016425302,-0.035560016,0.010546632,-0.015975308,-0.07386823,-0.03853265,-0.009795649,-0.026041916,-0.024196513,-0.050785363,0.014349762,-0.01578627,-0.004556805,-0.025222013,-0.029427307,0.027634988,0.04311421,0.025305266,-0.07811799,-0.010830735,-0.019533794,-0.056072563,-0.05464244,0.040295966,-0.036048714,-0.04232851,-0.08426888,0.053465825,0.008610405,-3.8407882e-33,0.10928142,-0.07771458,0.06504892,-0.1074672,-0.08916767,0.014387696,0.084171675,2.6484142e-05,0.020482479,-0.04570269,0.025906807,0.005848823,0.011257338,-0.048549045,0.045046207,0.032881018,0.06252788,0.05395009,-0.022736251,0.025490528,0.014518698,0.09591821,0.057698306,-9.179984e-05,0.049076613,-0.023884151,-0.011547471,0.09182686,0.11255134,0.033338685,-0.0035508801,-0.03577629,0.0036512127,-0.08423127,-0.0483102,-0.034440678,-0.053071134,0.011746224,0.036771007,0.032284938,0.033323593,0.04208698,-0.010602359,-0.062133998,0.051025223,0.087775886,-0.07391305,0.038352333,-0.0023661822,-0.023242313,0.0137453405,0.012503833,0.0032079858,0.05991872,0.065036595,0.015764851,-0.025081504,0.014457893,0.010506522,-0.059895787,-0.051880985,-0.0551882,0.10251034,-0.022945734,0.068432555,0.022568904,-0.03749363,0.014808423,0.019837381,-0.043504637,0.04278889,0.06355149,-0.0127924625,0.033555396,-0.042151213,0.024112448,-0.14246783,-0.091443144,-0.013015642,-0.01799955,-0.003438113,-0.025401687,0.020732714,-0.050863247,0.058813006,-0.10159164,0.10096684,0.14004943,0.022779252,0.061821558,-0.025417464,-0.05379194,-0.0055760825,0.07164056,0.07084486,-3.071964e-08,0.02681701,-0.038381115,0.035104726,-0.08246102,-0.04877956,0.05329143,-0.02460169,-0.019803882,-0.03645848,-0.058794204,0.028086606,0.060150582,0.008356339,0.06754368,0.009430599,0.021489158,-0.08894902,-0.034564808,-0.00641939,0.009909846,-0.07653306,0.012165654,-0.05509565,0.03775662,-0.04352078,-0.043147143,0.04571686,0.008779499,-0.09816245,0.012300949,0.0073191635,0.12172808,-0.058867242,-0.031430274,-0.028189123,0.013091069,-0.11928396,0.006139657,-0.014079332,0.0067721447,0.025333056,-0.030170597,-0.007600689,-0.012483701,-0.008236772,-0.00515168,0.012223499,-0.0071567902,-0.04563636,0.029483395,0.0642606,0.042656247,-0.07320318,-0.019515337,-0.072107784,-0.027646165,-0.0426797,-0.052653365,-0.033398412,-0.046093464,0.08614574,-0.027825842,0.16318619,-0.008720494 +2.4.1.320,The enzyme isolated from the anaerobic bacterium Bacteroides thetaiotaomicron is involved in the degradation of host-derived N-glycans.,384,1.0,-0.06561665,-0.018842766,-0.05475489,-0.0031933608,0.019978061,-0.028961303,-0.08629972,-0.0016958027,-0.012174174,0.008922391,-0.008641874,0.0779254,0.037776496,0.017396765,-0.099458545,0.0033270326,-0.038226184,-0.028437313,0.014283191,-0.0023601002,0.0314391,0.049933907,-0.015735129,0.0033971826,0.013590959,-0.00840543,0.0075417357,-0.045995824,-0.009263709,-0.035774,-0.077863045,-0.020149542,0.09772357,-0.03641645,0.06119773,0.09734301,-0.013521645,0.0011316432,0.011972919,-0.009011608,0.011936315,0.034527633,0.042226706,-0.05077064,-0.0031765706,-0.038641658,0.001221811,-0.0012039309,0.10986475,-0.0027638357,-0.040865425,0.012339449,-0.025969105,0.02701785,0.067618616,-0.014338546,-0.12869368,-0.10337337,0.008975403,0.06094785,0.068767734,0.07742552,0.009876313,-0.087253995,-0.047694296,-0.055477936,0.06930924,-0.04146009,-0.015373145,0.037343886,-0.044542275,-0.027246345,-0.045418773,-0.025079004,-0.012639022,0.06731686,-0.05491167,-0.022503497,-0.0030317253,-0.00027235888,0.0034905865,-0.029949572,0.05140547,0.064983174,-0.061226517,-0.021180723,0.018094582,0.034654718,0.088861436,0.020708129,0.002890589,0.01638266,0.045422748,-0.081970714,-0.04104507,0.00046121213,0.0018915865,0.032493044,0.016466646,-0.008330119,-0.033665806,0.03974911,0.03015969,-0.0823437,-0.07388201,0.033340245,0.07217291,0.105883114,0.11559836,-0.010081072,0.008980691,0.11040642,0.01297091,-0.006422962,-0.077261336,0.017129539,0.027324598,-0.029768184,-0.0971175,0.01124926,0.022405785,-0.017862683,-0.0052116555,0.02878609,0.0032788406,0.049844924,-0.013983806,-4.3210047e-34,0.09035579,0.034924652,0.03646307,-0.011579642,0.01795489,-0.045139965,-0.08450531,-0.03910707,-0.016354289,-0.06561429,-0.014374868,-0.045332316,0.009963279,0.08715275,0.010515072,0.098821715,0.014918121,-0.05525799,0.08906253,0.030639714,0.023158997,0.04817304,-0.0060860584,-0.027794003,0.05862847,0.02709158,-0.0044845357,-1.8147071e-08,0.012557755,-0.0376308,0.101507254,-0.09177155,-0.10500211,0.010405514,0.04796196,0.024800444,-0.017736992,-0.002593012,-0.0075015,0.06229996,0.009796145,0.09493267,0.03152217,0.027001744,0.017021235,0.022408828,0.012169617,0.0696164,0.051422082,0.07576255,0.02643062,0.0020689247,0.056776226,-0.06824217,-0.058686227,0.061749525,0.09006947,0.029042616,-0.021492355,0.09780861,0.053952657,0.0075171595,-0.0016504485,-0.0070164436,0.03665232,-0.030190201,-0.05052448,0.048398986,0.026329823,0.016194806,-0.07686299,-0.021666506,0.031131607,0.06409433,-0.058715213,-0.058686282,-0.0053584347,-0.054255452,0.040088538,-0.04672929,-0.043242436,-0.012079069,-0.019701365,-0.00947332,-0.08292695,0.049803823,-0.05149254,-0.018234588,0.050585754,0.013322889,0.023995098,-0.027850516,-0.06397216,0.02539898,-0.11382456,-1.4611632e-33,0.07659091,-0.06422329,-0.006627498,-0.021488653,-0.09833711,0.012694692,-0.03427663,0.05883655,-0.05193545,-0.049154185,0.050666004,0.013133647,0.040324163,-0.013712576,0.035736155,0.033015393,0.030078039,0.041114282,-0.070693836,-0.03087893,-0.05266555,0.07897329,0.02402081,-0.081724435,0.0014760141,0.048197053,0.042035993,0.12744732,0.022488013,0.029542435,0.027421068,0.053457048,-0.06830426,-0.112774804,0.01884644,0.104985245,-0.0073725055,-0.020736985,0.009662637,-0.06650585,0.10424365,0.09510031,0.0017913795,0.025586054,0.030452792,0.04212664,-0.061060883,-0.0013077949,-0.004737079,-0.0047099893,0.0019190245,-0.058938727,0.0063228537,-0.004647382,0.030972935,0.04704213,-0.011052893,0.06932973,-0.009479272,-0.054983992,-0.034703843,-0.023824928,0.0073535866,-0.03040229,-0.015326379,0.08267829,0.01782606,0.04995234,0.02115622,-0.010197038,-0.036406994,0.014593894,0.017364768,0.0009866429,-0.059381057,0.053370394,-0.06199278,-0.06839712,-0.04465824,-0.03155504,0.02997081,0.020293055,-0.03873777,-0.084709,0.052261565,0.0048818775,0.025575517,0.1226448,0.0259202,0.06288315,0.0014347465,-0.1052985,-0.060043518,0.03015445,-0.082403086,-2.6882786e-08,0.057356868,-0.012629534,0.0047490466,-0.03466605,-0.03357764,0.05140292,-0.04510973,0.007872266,0.045569297,-0.01246786,-0.043629028,0.01657514,-0.03759253,-0.055648122,-0.02987355,0.10786042,-0.07704949,-0.013891825,-0.046694312,0.029556109,-0.15822074,-0.020047346,-0.11518339,0.13801815,-0.0049416455,-0.057660833,0.057632998,0.0026211438,-0.029231839,-0.035902414,-0.03164145,0.059850547,-0.045804013,-0.039729554,-0.036774438,-0.12373697,-0.052150123,-0.019423915,0.077595994,-0.0043142876,0.0021442827,0.011311029,-0.10036278,-0.0025388969,0.026087057,-0.022954656,-0.0361532,0.003962406,-0.041492414,0.03174644,0.066476464,-0.075066954,-0.00600244,-0.015261238,-0.10095619,-0.037875414,0.029376846,-0.015292087,0.0133806905,-0.03816521,-0.06450684,-0.012768081,0.16296583,-0.064293385 +2.4.1.321,The enzyme occurs in cellulolytic bacteria and fungi. It catalyses the reversible phosphorolysis of cellobionic acid. In the synthetic direction it produces 4-O-beta-D-glucopyranosyl-D-glucuronate from alpha-D-glucose 1-phosphate and D-glucuronate with low activity.,384,1.0,-0.056419484,-0.013714533,-0.07683575,-0.005837156,-0.017083257,-0.0066542574,-0.02205171,0.02275643,0.06884545,0.06548684,0.002481127,0.0378575,-0.0769199,0.026502054,-0.09801673,-0.019349538,-0.002641733,0.04231709,-0.03595661,0.022233393,0.12015195,-0.006252969,-0.013748472,-0.032714292,0.10662648,-0.0014859895,0.056360513,-0.045338564,-0.04129871,-0.02905398,-0.04182899,-0.029911825,0.095535725,-0.023865819,0.0537513,0.11596499,-0.011018545,-0.03859725,0.07745473,0.034007624,0.008732285,-0.027965896,0.007070326,0.01575863,-0.063747205,0.018576946,-0.019349415,0.04855769,0.031697374,-0.009116157,-0.016391383,-0.0449127,-0.052009,0.002621684,0.028466249,0.004458796,-0.006351781,0.04675849,0.041016426,0.042256616,0.053611178,0.011579153,-0.02082246,0.029360747,-0.007905156,-0.086971864,0.039678283,-0.07253114,-0.027867718,-0.07368644,-0.014364327,-0.0073897145,0.020069325,-0.029796956,0.03241038,0.0430818,-0.02577317,-0.09114461,0.05252867,0.014518691,0.14070693,0.029457865,0.0075283656,0.055833038,-0.0055559343,0.035852287,-0.0004586354,0.033765197,0.06141349,-0.02280694,-0.004128599,-0.030272549,-0.029463146,-0.03453868,-0.06988517,0.034461394,0.05252078,0.023710102,0.07454647,-0.04535709,0.008523924,0.046510424,0.11477326,-0.10348666,-0.07220558,0.0038098737,-0.022548383,0.1013644,0.013171251,0.012351615,-0.042311408,0.05700886,0.016963866,-0.0045412066,-0.11551016,0.112882316,0.06889348,-0.0841783,-0.1509775,-0.003524356,0.000101159814,-0.107796595,0.027533391,0.041017488,-0.08774242,0.04435112,-0.028151793,1.0233395e-33,0.03167588,0.028274877,0.011652662,-0.07992247,0.010260854,-0.03707952,-0.055795174,-0.04333088,-0.033300523,-0.025387285,0.01383846,-0.043889724,0.01697509,0.09065385,-0.05016712,0.049332004,0.01802263,-0.032697316,0.058113806,0.03174337,0.06309137,0.059060797,-0.041062944,0.017128274,0.051614955,0.055308487,-0.025436273,0.01819573,0.0757122,-0.017877443,0.030671267,-0.05410701,-0.07145994,-0.011762782,0.015391446,0.018866325,-0.11293068,-0.043918505,0.01763485,-0.0013380181,0.020752862,0.012652424,-0.0021250206,0.0064937416,0.059488438,0.02167841,-0.04345867,0.05602447,0.011892666,0.10626742,0.046260733,0.051508773,-0.0070323,0.03324618,-0.03760603,0.032223772,-0.024221681,-0.09954519,0.04036017,0.041647583,0.038968567,0.074309416,-0.052917197,0.02820767,-0.026305463,-0.08360417,-0.047028195,-0.035860837,-0.04510959,0.039590426,-0.042855676,-0.075795494,-0.035832226,0.033793215,-0.046432987,-0.0476156,-0.010338547,-0.024211422,0.046051268,-0.09834982,0.008891172,0.033567686,0.009155027,-0.04058542,-0.08706076,0.03409559,-0.029500186,-0.04757453,-0.08325817,0.022323148,-0.009816437,-0.07533881,-0.07232007,0.04333582,0.014621107,-2.8984082e-33,0.121505976,-0.11211247,0.04933228,-0.08595566,-0.026573034,0.038686343,0.012344915,-0.044662964,0.010456343,-0.0044343653,0.031024948,0.010748874,0.004266486,0.04343413,0.016825577,0.027299633,0.0007656059,0.06348044,-0.06446322,0.016981168,0.033024047,0.06850607,0.08265583,0.0077539794,0.04196001,-0.029157639,0.033488262,0.040133715,-0.0053834543,0.07198679,-0.019511696,-0.005486178,-0.022420194,-0.021026278,-0.04336152,0.0347711,-0.06860212,-0.027109424,0.05269435,0.0046258955,-0.0005336389,0.036692146,0.03683208,-0.016459202,0.037057053,0.06623242,-0.04107282,0.052980546,0.014182495,-0.06604257,0.011516375,0.07169397,-0.037530355,0.033756103,0.05585437,0.06952954,0.0065727765,0.023159962,-0.09209921,-0.08419712,-0.06343211,-0.049671736,0.05604581,-0.053707782,0.07293676,0.08001804,0.003916956,0.036109585,-0.01263304,0.04639785,0.05664687,0.048485797,-0.06629313,0.03876194,-0.046954595,-0.041974712,-0.09748962,-0.0035109078,-0.018783337,-0.0036833298,0.033930574,0.056610193,0.02196108,-0.026649054,-0.0010202887,-0.13407686,0.06726151,0.10058289,-0.020139115,0.08500683,-0.044418566,-0.0043763528,-0.01913386,0.04539081,0.14005406,-3.310983e-08,-0.037555195,-0.016210098,0.029591799,-0.101074785,-0.029646983,-0.026496878,0.013028239,0.012228806,0.039800584,-0.052976385,-0.029509665,0.11393855,-0.013277174,0.03028212,0.024924448,0.049239226,-0.08200398,0.0036249734,-0.025622282,0.0035963487,-0.05496348,-0.0007778389,-0.065826446,0.031709734,-0.053681295,-0.052031696,0.060705017,0.0026223834,-0.05584223,0.03810865,0.01640576,0.03716135,-0.03539295,-0.1098327,-0.07426318,0.002325159,-0.02995457,-0.047744043,-0.019235043,-0.009645948,0.03898902,-0.011567675,-0.03334821,0.04130389,-0.04147457,-0.012229233,-0.026885696,-0.01198519,0.0018000097,0.08845239,0.0558018,-0.033108003,-0.07397426,-0.091413625,-0.08147591,-0.012366659,-0.040607683,0.0074508884,-0.014765056,-0.0023549139,-0.008182092,-0.01785474,0.16950007,-0.011837647 +2.4.1.322,"The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin. ",384,1.0,-0.054031216,0.02528883,-0.095023,-0.035269387,0.06567391,0.016961614,-0.07605129,0.00016797711,0.06651559,-0.024843462,0.0032775858,-0.022404993,0.0574874,-0.012455943,-0.047522623,-0.006888094,-0.07157453,0.038803957,0.020272233,-0.027245669,0.018485935,0.0062993513,0.057156477,-0.01157965,0.06322313,0.022305349,0.03248359,0.0211839,-0.027794264,-0.07145163,0.049841024,-0.028334646,0.029001068,-0.04142514,0.060430307,0.007968153,-0.09833699,-0.026856737,0.15368979,-0.028603552,-0.018114122,-0.03333625,-0.030027084,-0.011753815,-0.045067687,0.010787269,-0.003506262,-0.053555235,0.05397606,-0.021414656,-0.022630332,-0.02655626,-0.034991078,0.032800525,0.05168753,0.056074653,-0.037839603,-0.028070722,-0.03333543,-0.023859931,0.08072609,0.020052673,-0.0058989245,0.0255543,-0.10968639,-0.06570007,-0.0046123513,-0.03609419,0.054436017,0.01048845,-0.09814508,-0.024893867,-0.022149907,0.049164098,0.050054528,-0.01224502,0.010871666,-0.034381732,-0.018107936,-0.020986294,0.029974192,0.038186308,0.027132763,0.101624094,0.048241265,-0.041396316,0.12661684,0.004735471,0.11496916,0.07236017,0.05945804,-0.0073637725,-0.026530499,-0.08091442,0.006769202,-0.03620229,-0.01513795,-0.042249836,0.054602906,-0.03624364,0.005405346,0.021208065,0.04292911,-0.13688897,-0.004277616,0.021536544,0.009838926,0.06294319,0.055067685,-0.028756248,-0.0007002725,-0.030712992,-1.7849487e-05,-0.0046061645,-0.073086224,0.05875678,0.091468394,-0.060180422,-0.075739875,-0.031345878,0.01726512,-0.0151697425,0.035577428,0.07057626,-0.04340074,0.016815623,-0.10967362,-7.713193e-34,-0.028922265,0.09375755,-0.030676303,-0.061159074,0.06941426,-0.031287663,-0.057662748,-0.013472199,-0.056635745,0.019885756,-0.123271056,-0.097375795,0.0061902283,0.079344794,-0.011106255,0.008481985,0.025712179,0.026173458,-0.0036211805,-0.0024003112,0.047381602,0.05673529,-0.014076604,-0.03644125,0.007037548,0.025905104,-0.0008355454,0.03281523,0.08224563,-0.020913115,-0.019239059,-0.045460396,-0.032497488,-0.0013794602,0.05634372,0.025679946,-0.012776595,-0.04508701,0.08914704,0.042993117,0.06805289,0.065142594,0.007962504,-0.050199967,0.011099605,0.042251453,-0.023808682,0.098573744,0.06999382,0.061282888,0.054884765,-0.07167888,0.047016803,-0.037787553,-0.054731134,0.0490465,-0.02672743,0.033186015,0.039024457,0.063447826,-0.04866826,-0.009276753,0.018112753,0.018332772,0.05061643,0.026229896,-0.033502765,-0.04305723,-0.054568805,0.011129168,-0.08469808,-0.039150894,0.06510284,-0.053340983,0.06759122,0.004351997,-0.07663394,-0.052599408,0.08546525,0.0057619414,-0.06203438,0.053950388,-0.010248635,-0.056240257,0.025732242,0.0080607,-0.06965393,0.01699723,-0.045837108,0.08829904,-0.014124454,-0.093022205,-0.05965395,0.052542005,-0.02422704,-1.6245499e-33,0.09935217,-0.09865007,0.061976563,-0.07265341,-0.027734982,0.057736997,-0.040700376,-0.023013266,0.0040149796,0.030712662,0.056554794,-0.043585517,0.047394272,-0.019834323,-0.013377577,-0.038137663,0.05515598,0.13309468,-0.01095428,0.040385015,-0.0064479713,0.046168603,-0.021142686,-0.05818743,-0.006099731,0.039537538,0.024537517,0.0685476,0.021318156,0.045887515,-0.024474801,-0.036681693,-0.03602522,-0.06329463,-0.048792973,0.1318849,-0.031087404,-0.050499324,0.031413104,0.005021689,0.027795685,0.0075526447,-0.018889226,0.018166596,0.02868469,-0.022873383,-0.063930735,0.048485316,-0.0013975851,-0.06805154,0.041389115,0.0008747482,0.06215668,0.015738478,-0.022056103,0.05108151,0.0038485972,0.0049692127,0.01458645,-0.08042986,-0.058512386,-0.017870873,0.043822866,0.013292676,-0.004625646,0.086865194,-0.045465667,0.06972042,0.06617178,-0.0988494,0.0539115,0.07844529,-0.012668781,0.030447768,0.029253237,0.02017001,-0.025641942,-0.10428886,0.027534211,0.025414322,-0.019894946,-0.005885453,-0.042159215,-0.055560365,-0.10432297,-0.04017283,0.02802618,0.07513018,0.010452082,-0.01415608,0.008303237,-0.018712543,-0.022011813,0.09275812,0.02674232,-2.8012744e-08,0.0108198235,-0.056219306,0.07221885,-0.03694861,-0.0035450058,0.015885515,-0.008517613,-0.0070611183,0.0050789965,-0.02209413,0.009420184,0.09691581,-0.024067547,-0.012869496,-0.0065905536,0.029047769,-0.052335493,0.03872069,-0.0052972245,-0.016465621,-0.06590501,0.019724475,-0.08581847,-0.0076020663,0.06339407,-0.05448485,0.00671324,-0.01812897,-0.090759255,-0.06441306,0.0033544444,0.037460875,-0.07767978,-0.038430646,-0.05357109,-0.032693714,-0.0731793,-0.062143907,0.083250396,-0.038930528,0.0741711,-0.012975338,-0.071991414,-0.0030763764,-0.099955775,0.04350051,-0.02268158,-0.01306652,-0.047673047,-0.03917812,0.06521669,0.02863983,-0.013195734,-0.05767122,-0.0636502,0.02736496,-0.0065681185,-0.060637023,-0.023393383,-0.05415155,-0.050054614,0.0024956719,0.2395402,-0.0053253267 +2.4.1.323,Isolated from the plant Catharanthus roseus (Madagascar periwinkle). Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetin. cf. EC 2.4.1.324 7-deoxyloganetin glucosyltransferase.,384,1.0,-0.08501502,-0.028557424,-0.16313207,-0.028087243,-0.014250722,0.048274614,-0.032043345,-0.014171946,0.062056653,0.0045591565,0.112297505,-0.045353405,-0.057250444,-0.022646325,-0.10571329,0.08744435,-0.049726844,0.055264574,-0.052238766,-0.015198409,-0.0028737034,0.060856488,-0.0065638083,0.023825154,0.033663683,0.044600926,-0.06910231,0.062493384,0.04556815,-0.049801257,0.014500767,-0.01985956,-0.030478211,0.028166482,0.06008869,0.078326546,-0.04080345,-0.040594332,0.11709207,0.061756056,0.026415933,-0.026991365,0.017636348,-0.03463586,-0.013636989,-0.022272201,-0.047983952,0.014131482,0.041792363,-0.098146364,0.0071555274,-0.042318158,-0.04739616,-0.037247468,0.011383153,-0.122801505,0.026068494,-0.05651478,-0.04355999,0.025567843,0.02169021,-0.016470075,0.018769285,0.015565093,-0.066248715,-0.013788199,-0.035873827,0.015610468,0.12047902,-0.0954026,0.036300924,-0.044303454,-0.019782498,-0.017977312,-0.09820312,0.06748212,-0.019165779,0.047779776,-0.037164837,-0.004990525,0.07458475,-0.013348326,0.14918311,0.11931795,0.04624593,-0.043714643,-0.001277368,0.09171528,-0.0303984,-0.0019180543,0.015617609,0.01834499,0.066405706,0.02357103,-0.023109004,0.026737383,0.021804214,-0.042662103,-0.04447049,0.026157709,-0.046616167,-0.00029294286,-0.0424365,-0.08395722,-0.049988788,-0.007956347,-0.017967595,0.06251584,0.08923666,-0.06174292,-0.027024534,-0.020666104,-0.021227382,0.053763367,0.012229587,0.02720027,0.06739026,0.032442886,-0.0028338726,0.021664884,-0.012513677,0.012058413,0.021512061,-0.0019030304,-0.028459007,0.021767814,-0.022771638,4.3619995e-33,0.12627912,0.03908163,-0.05114584,-0.03740918,0.0062022083,-0.0059732283,-0.06982804,-0.017274754,-0.031179158,-0.027069123,-0.1411258,-0.08508587,-0.024694212,-0.019903075,-0.021922836,0.027907368,0.03147567,-0.0684931,0.072754905,-0.030155046,0.04140964,0.036822483,-0.06912064,-0.017262544,0.014828134,0.05495823,-0.016322628,0.0072504985,-0.019000929,-0.022417022,0.007716525,-0.12004321,-0.022303736,0.0025788932,0.048625015,-0.02552317,-0.103401475,-0.027001902,0.02216477,0.10083953,0.026948163,0.0041374974,0.0068945666,-0.03940567,0.14895858,0.047884427,-0.0015357914,0.10791766,0.07366634,0.03932057,-0.008697211,0.050025385,0.053977802,0.03537178,-0.09528311,-0.04103195,0.060616028,0.03914973,0.072066255,0.07497132,0.020150147,0.018696696,-0.033460487,-0.06751288,0.060036045,0.006232932,-0.046210244,0.027277665,-0.069528304,-0.0035419133,-0.013456417,-0.03956065,0.036459915,-0.03297463,0.07499236,-0.049271315,-0.012151882,0.06533358,0.026597165,-0.015165997,-0.012761616,0.02386439,-0.0008345922,0.0030497597,-0.097927086,0.057123568,-0.026826512,0.054073833,-0.010365857,0.035345726,0.0009930385,0.015041462,-0.06226895,-0.05888239,0.06943601,-4.502002e-33,-0.009973681,-0.0052189347,-0.037065066,-0.07825868,-0.053449295,0.09799042,-0.074108124,0.052771162,0.03571794,0.03285485,0.021886418,0.03301817,0.08829848,-0.008896564,-0.044033017,0.018645506,-0.0048255534,0.12480023,-0.029430274,-0.023791252,-0.0035399431,0.05724615,-0.044172287,-0.0010827801,0.08289355,-0.016598577,0.03925685,-0.0030973426,0.026333574,0.017707206,0.000335932,0.02267642,-0.07098155,-0.049056236,-0.10429865,-0.0018935272,-0.079554476,-0.02009118,-0.028182384,0.026613597,-0.0055850586,0.022138014,0.014919185,0.08526423,0.090395406,0.037369154,-0.058993645,-0.008956108,-0.06723508,0.05378786,-0.0019914992,0.05659514,0.04875184,-0.007452889,0.029146876,-0.015286193,0.06815242,0.00841153,-0.0035936383,-0.026762884,-0.016810644,-0.080435805,-0.0017082536,0.026641661,-0.0014069062,0.10308129,0.0046130274,0.06223892,0.06761619,-0.046622507,0.047138415,-0.050423104,0.0014151364,0.004110572,-0.0036583007,0.010939615,-0.06685072,-0.05729609,0.0032163977,-0.030533921,-0.02351466,-0.03544271,0.03682241,-0.08786628,-0.026749121,-0.03559186,0.07788029,0.044636387,-0.003029547,-0.009012789,0.022153651,0.07957921,-0.02943932,-0.031280622,0.050833054,-3.413117e-08,0.044698495,-0.026363358,0.0323077,0.007555175,0.013774439,-0.03007073,0.01249461,0.033495933,-0.020802062,0.026607256,8.1337115e-05,0.01997742,-0.025409343,-0.016822929,0.0060540484,0.028841194,0.11404252,-0.02956835,0.009586799,0.008406803,-0.07692135,0.027036868,-0.007813338,0.00991969,-0.0244673,-0.12110024,0.05179525,0.03265453,0.04664437,-0.066496275,0.043461367,0.023340395,-0.02950083,-0.094673015,-0.09523189,0.03832517,0.02321021,-0.048342258,0.06940191,-0.071865745,-0.07119921,-0.07741076,0.036289196,0.025765214,-0.04102117,0.02272614,0.072134845,-0.02178834,0.018616857,-0.042941444,0.06773961,-0.050244257,0.030924179,-0.07302657,-0.10994637,0.055042136,0.021687299,-0.034584872,0.027528072,-0.053152338,-0.06320666,-0.05034747,0.09194646,-0.024434287 +2.4.1.324,Isolated from the plants Catharanthus roseus (Madagascar periwinkle) and Gardenia jasminoides (cape jasmine). With Gardenia it also acts on genipin. Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetate. cf. EC 2.4.1.323 7-deoxyloganetic acid glucosyltransferase.,384,1.0,-0.08523454,-0.033202384,-0.12210017,-0.023523524,0.01909829,0.049155675,-0.003684877,-0.03962282,0.04215166,0.0044333446,0.10777739,-0.043177616,-0.053336512,0.012247449,-0.09347971,0.10175991,-0.009526923,0.037739407,-0.060645014,-0.004485086,0.014413583,0.061098948,0.005452512,0.017162105,0.020424213,0.043998726,-0.044857606,0.06420211,0.022838285,-0.061642572,-0.03169543,0.04361527,0.0008750461,-0.0020205842,0.042110696,0.04899627,-0.037794393,-0.035964504,0.11445067,0.034113232,0.008064539,-0.056633055,0.0397647,-0.09420806,0.0074769487,-0.038557548,-0.07287429,0.005757389,0.057452023,-0.045699716,-0.012893676,-0.04256566,-0.02478147,-0.0077766073,0.003407022,-0.14536862,0.041161995,-0.037392303,-0.032315128,0.038501672,0.037407633,-0.009701739,0.01014167,0.025085635,-0.06903737,-0.032405473,-0.03913932,0.012358976,0.08293302,-0.120748386,0.007796969,-0.082675435,0.02368332,-0.021414438,-0.08314934,0.097549014,-0.035824224,0.04085069,-0.0404291,-0.018898271,0.043550305,-0.012550612,0.12841542,0.14314954,0.0021719593,-0.023428624,-0.000802148,0.076095656,0.02306904,0.017008841,0.0052369335,0.01698683,0.07127871,0.035791337,-0.029035872,0.02541962,0.032073256,-0.1122156,-0.03728669,0.025997596,-0.029890366,0.006860638,-0.009714988,-0.059226982,-0.09503604,0.03171186,-0.052984696,0.026016984,0.052767195,-0.08545113,-0.032180097,-0.01189115,0.007281543,0.048109353,-0.02397623,0.017220767,0.09045539,0.016042326,0.0035227844,-0.00938779,0.0076063666,-0.032277796,0.03164107,0.012069215,-0.0077827876,0.068642244,-0.078776345,6.0015422e-33,0.15815425,0.031794764,-0.011080537,-0.016447872,0.0036585603,-0.0016809201,-0.069363,-0.026493488,-0.04080502,-0.06088423,-0.12801658,-0.07267994,0.046733834,-0.031601824,-0.006828767,0.04014094,0.01751624,-0.060995594,0.075332575,0.011061577,0.06392222,0.07355443,-0.07318847,-0.028686522,-0.0041908557,0.07805409,0.008626682,-0.012005168,-0.012960023,0.002721593,0.06865697,-0.08645625,-0.023679413,0.023059934,0.047790803,0.012124693,-0.09193435,-0.050126053,0.0011854846,0.08941844,0.007815781,0.014796398,0.010939844,-0.027876358,0.09462462,-0.0069333026,-0.027140059,0.08256529,0.08179252,0.06338709,-0.03322574,0.04716064,0.029833375,-0.0024935596,-0.07413013,-0.022994127,0.03025196,0.049017947,0.07635016,0.05894272,0.015050086,0.019872747,-0.053062525,-0.07000982,0.06531857,0.010643346,-0.06611758,-0.0080764815,-0.09407226,-0.0077853585,-0.0026355248,-0.03618774,0.051288556,0.011183964,0.053510632,-0.06207515,0.033692736,0.07025265,0.007561696,0.015193739,0.01912144,0.0019729275,0.008182478,-0.014689945,-0.088024795,0.03319287,-0.041226413,0.024547614,-0.045236908,0.011320966,0.02170521,0.006927689,-0.07804173,-0.05282037,0.019476384,-5.6774412e-33,0.02344429,-0.019266492,-0.029346718,-0.052707154,-0.031448137,0.03652624,-0.100810334,0.03333291,0.016633801,0.038650118,0.02526469,0.053650044,0.107813634,-0.010670834,-0.041587457,0.030723782,0.030745711,0.092202045,-0.01895236,-0.033196323,-0.0041339616,0.063100815,-0.0039439197,-0.022407178,0.058787666,-0.014121754,0.037149206,-0.0218289,-0.007862554,0.022616617,-0.0022152374,0.018967982,-0.07528936,-0.0710875,-0.040210914,-0.020758398,-0.10019219,-0.046239283,0.011535249,0.03196774,-0.044064324,0.02374283,0.054788284,0.06991865,0.10848662,0.016197987,-0.08559904,0.038777035,-0.023559103,0.043319378,-0.0050355396,0.0676927,0.04145319,-0.029556794,0.07088894,0.003802473,0.09555515,0.011322201,-0.022809384,-0.0020365498,0.035888504,-0.054347955,-0.0033839503,0.023738466,0.018579999,0.14315642,-0.014298002,0.08124207,0.052996427,-0.042441443,0.056784384,-0.04677901,0.03233268,-0.0076065366,0.004727596,-0.022547046,-0.0725088,-0.034394488,0.0011183105,-0.028183362,0.028635804,-0.00019831413,0.04044014,-0.09779065,-0.005174951,-0.029830443,0.029663846,0.059434146,0.011210332,-0.027407303,-0.007490256,0.04666649,-0.03421395,-0.026920201,0.088480726,-3.8749494e-08,0.05514867,-0.05275431,0.02544538,-0.01949771,-0.02799962,-0.029568383,0.036805168,0.013370793,0.021260792,0.0082824305,0.00016018539,0.064975776,-0.003802154,-0.00017274045,0.011429506,0.030268645,0.109345056,-0.009314705,-0.03244392,0.023767835,-0.027694715,0.00074627245,-0.017732935,0.004618501,-0.039366342,-0.12860146,0.04058413,-0.02104541,0.05433959,-0.11231397,0.0057753786,0.023258619,-0.030571528,-0.12506692,-0.09032923,0.050761435,0.010285648,-0.04708172,0.049974635,-0.045710545,-0.048001587,-0.10487076,0.03320576,0.023317348,-0.031072836,0.0053487676,0.048382923,-0.028545724,-0.014122507,-0.04798301,0.057602208,-0.038958907,0.03829141,-0.05809621,-0.10090172,0.04050906,0.05944299,-0.033541333,0.07888986,-0.042263135,-0.091447674,-0.03996816,0.093417265,-0.018129788 +2.4.2.57,The enzyme from archaea is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The activity with CMP and UMP requires activation by cAMP [2].,384,0.99999994,-0.0951866,-0.061371066,-0.048888974,-0.00011503945,0.043350182,0.022051178,-0.060015824,-0.03466347,-0.03320892,0.04372702,-0.02670346,-0.0376156,-0.0748964,0.05640559,-0.0069230227,0.034923248,-0.0017416395,0.02301528,0.04238536,0.00014377445,0.074105285,0.03253694,-0.013907908,-0.010162164,-0.022221388,0.004949662,0.019385215,-0.02884209,-0.06974356,-0.06903955,-0.024412494,-0.0034669493,0.049305197,-0.10318228,0.0346318,0.11095304,-0.059117157,-0.062263086,0.0338856,-0.0154837025,0.035795342,0.041512124,0.07905122,-0.02787148,-0.021888068,0.0036080969,0.064005144,0.0027155238,0.042204287,-0.07125444,-0.015426733,-0.020864025,-0.07781001,-0.008911533,-0.03884339,0.046634458,-0.051494714,-0.013975651,0.025498588,-0.060310557,0.05559117,-0.0013203991,0.02727044,-0.0021863945,0.051428173,-0.024982747,0.0023486759,-0.06286621,0.054856226,-0.04157085,-0.07526136,-0.07184426,-0.03684774,-0.0082432525,0.032426834,0.066348664,0.02788803,-0.015625492,0.08676741,-0.04026835,-0.025563758,0.0187999,-0.017731017,0.0076208236,0.02167181,0.008250717,0.088513814,0.032692462,-0.0005277355,0.051109593,-0.00058219914,0.0045066187,0.028477803,-0.03505074,-0.042295128,0.0011445582,0.0371464,0.07515245,-0.009983471,-0.054095462,0.028920658,0.088001885,-0.0055324407,-0.11780745,-0.04991286,-0.08458489,0.021138612,0.16555391,0.08383434,0.017396456,0.036132004,0.05881656,0.019464746,0.010332358,0.046369545,0.122025155,0.051704254,-0.06756259,-0.0736241,0.06894099,-0.028734637,-0.08562877,0.0017962097,0.02468159,-0.05453664,0.024992302,-0.041229587,8.5333185e-34,0.052532233,-0.0614794,-0.00858288,-0.016839914,0.019366832,-0.009196119,-0.15261064,-0.06896423,0.021489281,-0.04017108,-0.046368573,-0.015882373,0.077326894,0.036327977,-0.13293274,-0.015726158,-0.02450791,-0.003631565,0.09304307,-0.051711164,0.008411837,0.06511545,-0.0068387133,0.0119754635,0.07221185,0.07843904,0.028594907,0.0076279095,0.037653644,-0.00952075,0.054415856,-0.104239464,-0.12796606,-0.019173456,0.03983188,-0.004727373,0.0121698715,-0.06433042,-0.046686,0.012551057,-0.02879379,0.09954916,0.004544437,-0.00093007484,0.01701584,-0.057714693,-0.018724281,0.12286216,0.04547342,0.07175894,-0.03095962,-0.012997256,0.103987426,0.018552963,-0.04858398,-0.008323368,-0.03722704,-0.010935273,-0.0047606057,-0.0013032268,0.086186856,0.080053926,-0.012462486,0.0955667,-0.0028279384,0.03255044,-0.029831816,-0.0016769256,0.10205618,0.102819815,-0.04805744,-0.02697556,0.057699036,0.026210915,-0.020955,-0.06797237,-0.011443026,0.0057040313,-0.014296572,0.065313786,-0.060465727,-0.10429332,0.055562228,-0.0127559025,-0.03180669,-0.004637144,-0.046692654,0.00022199692,0.033908427,0.02475757,0.059739936,0.027121918,-0.05243476,0.05992822,-0.024407562,-2.1881045e-33,0.112487346,-0.12479944,0.045112755,-0.09954308,-0.09477294,0.038269624,-0.055663638,-0.08295109,-0.0011709215,-0.08290453,0.04195252,-0.002882042,0.05278471,-0.05837801,0.06392496,-0.092503555,-0.045131058,0.04338332,0.03727049,0.08562849,0.011960589,0.022534763,-0.014387686,0.010726173,0.044303466,0.023041977,-0.0035079801,0.05544689,0.03515989,0.010739394,0.07164374,0.07632738,-0.089535646,-0.049814094,-0.03237347,-0.030915486,-0.017395904,0.043113884,-0.01772167,-0.026668891,0.06430426,0.047189683,-0.081687056,0.04606928,0.032276407,0.03032885,-0.03351773,0.05562136,-0.032384634,0.0137796635,0.020227084,-0.09231799,-0.043440964,-0.05367608,0.051727507,0.03083338,-0.0077449563,0.028529705,0.008580799,-0.02647329,-0.036003206,-0.08503758,0.023619123,-0.033528317,0.0077749034,0.10230738,0.009998187,0.021682862,0.009425721,0.033736907,0.052583646,-0.0069978787,-0.01303868,0.0015934166,-0.04227929,0.01656225,-0.040179625,0.0051871054,0.027722485,-0.07099333,-0.056371357,0.023031268,-0.023063585,-0.04889994,0.02319444,-0.01536808,-0.0026752483,0.06320663,0.000638921,0.019144313,-0.058540802,-0.06407082,-0.009742264,-0.05013047,-0.005441739,-2.8145866e-08,0.015095656,0.045079865,0.04361824,0.039055888,-0.051568143,0.11012333,0.013447865,0.041841235,0.04373395,0.03829641,0.050080128,0.04651656,0.08899131,-0.053493116,0.080140896,0.04778646,-0.011973163,0.034414906,-0.012635524,-0.0058800383,-0.08052065,-0.07201593,-0.035597656,0.100194626,0.014667643,-0.05308812,0.041085493,0.089259416,-0.047297895,-0.07041948,0.02108802,-0.03542177,0.061215024,-0.054388463,-0.030852558,0.02151671,0.011019492,-0.015305428,0.008617539,0.021531578,-0.061261833,-0.008695446,-0.06237253,-0.020973645,-0.056887325,-0.026893452,0.019723728,0.045937683,-0.062023025,-0.041351836,0.035410408,-0.03706742,-0.020003747,-0.06609971,-0.020432556,0.022193952,0.0026952494,-0.060749102,-0.017750787,0.030766847,0.051212415,-0.019867415,0.012388358,-0.12267027 +2.4.99.20,"This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.",384,1.0,-3.0435043e-05,0.030489532,-0.0013904871,-0.014943529,0.0404035,0.022397878,-0.050427966,-0.035901736,0.08081049,0.050745122,-0.008103029,-0.021197539,-0.016077662,0.026340831,-0.016735582,-0.039005376,-0.06923972,0.037790377,0.038679548,-0.039354756,0.09674679,0.020954918,-0.010004559,0.023169873,0.011011096,-0.0032748221,-0.01140266,-0.019103747,-0.034036193,-0.0045223758,0.013561425,-0.020024562,0.0050837523,-0.06471664,0.00017250184,0.064102836,-0.112183645,-0.024696993,-0.10479124,0.010500291,0.040403858,0.045433946,-0.03542651,0.015927695,0.009507064,-0.0064059393,-0.02243071,0.01541332,0.028193055,-0.034628004,-0.047843087,-0.013322662,-0.021122469,-0.016153557,0.01390495,0.042900126,-0.09245617,-0.027114317,0.016308786,-0.04894248,0.03500857,0.0043054367,-0.022486674,0.015020998,0.0944778,-0.039044447,0.041116875,-0.048487432,-0.002349829,-0.012361825,-0.11085224,-0.049787633,0.020363307,-0.01629193,0.028360806,-0.018213425,-0.06855456,-0.03274604,0.108498335,-0.032389745,0.06201576,-0.014709714,-0.02982233,0.07057108,0.046598118,0.060570225,0.049766567,-0.00482137,0.03751341,-0.020156251,0.015066274,0.033717915,0.04845261,0.026255196,-0.14017381,-0.0025618817,-0.0049390653,0.10147593,-0.05377057,-0.042020697,0.06837055,0.17783196,0.010633283,-0.10389476,-0.025661001,0.040659882,-0.026708636,0.081371896,-0.02992459,0.03351305,0.014979587,0.009683803,-0.059920777,-0.056860857,0.041328672,0.22576596,-0.036364615,-0.04640188,0.011741775,-0.038675662,0.0048010782,-0.0992405,-0.017355198,0.01732862,0.019421015,0.05390966,-0.08446235,3.1643276e-33,0.01193825,0.01859478,0.0029275292,0.01428922,0.03962655,0.0036279645,-0.08758812,0.009280757,-0.036928274,-0.04458779,-0.018448532,-0.06936704,0.008575336,0.042067297,-0.0010483768,-0.051788505,-0.06430636,-0.052453093,0.07646147,0.011386635,0.027293568,0.0441295,-0.023847278,0.07804145,0.015809134,0.05331468,-0.060455404,0.011475844,0.025192227,-0.006738208,0.06842014,-0.017244356,-0.15746213,-0.012494317,0.037627798,0.003177378,-0.0037820928,-0.013687223,0.028836694,0.09984222,-0.041298505,0.004710292,0.104524635,-0.03367401,0.033815946,-0.07892733,-0.10300509,0.054780412,0.07078764,0.014480296,0.06916947,-0.041806437,0.10101572,-0.022598648,-0.055139948,0.056058228,-0.052328177,-0.054121632,-0.058095958,0.017332783,0.017450284,-0.019797964,-0.012853738,0.0953407,-0.07945316,0.054332994,-0.018240519,-0.12435489,0.05072724,0.022957928,-0.0655175,0.053106584,0.1358706,-0.036547344,0.008153159,-0.026124576,0.011585809,0.0076792897,-0.035209298,0.05890371,-0.037069622,-0.094979614,0.004285207,0.083939515,0.099491596,-0.03307241,0.024076872,-0.010944967,0.00037990676,0.0941047,0.005575187,-0.010888076,0.003301036,0.05352015,0.005474244,-3.6064152e-33,0.117868915,-0.037233736,0.04025956,-0.08045132,-0.02709053,0.028805096,0.04419772,-0.11117377,-0.00094193086,-0.097331576,0.01479609,0.0413407,0.124962635,-0.009854141,-0.029432742,0.0134365875,0.05072576,0.043361455,-0.031935785,-0.0095952,0.008326655,0.06877568,0.0048547685,0.00051126955,0.097773485,-0.026840135,0.0164511,0.03186322,0.040552374,0.007049894,-0.02097698,0.01260543,-0.025904892,-0.027612997,-0.047842238,0.07223833,-0.014951917,0.018829647,-0.019361008,0.07192947,-0.04972248,0.020311391,-0.05499919,0.010467237,0.06358102,0.051844083,0.0017486876,0.033599548,-0.09198513,0.0047740727,0.053170774,-0.0020282331,-0.06692952,0.08490451,0.018192332,0.09755376,0.037584018,0.07109405,0.015187471,0.0035933515,-0.03924293,0.027167033,-0.03147471,-0.051233843,0.051312383,0.030777765,-0.0063092406,0.01986739,0.0034476514,-0.025376022,0.032280203,0.019628976,-0.016220342,0.01685538,-0.008597056,-0.0010455893,-0.10240565,-0.00857244,-0.003989933,-0.07114865,-0.005622929,0.005184351,0.06750444,-0.014461782,-0.074035704,-0.07886527,-0.009016868,0.07148623,-0.040908623,-0.007109132,-0.026820647,-0.04658562,-0.028153822,0.018775743,0.022240998,-3.8858648e-08,0.022388024,-0.006277434,-0.046815824,-0.1397241,0.048718866,0.009225599,0.02113111,0.021694835,0.026563955,-0.06250501,0.007991856,0.06749281,0.023797596,0.037495796,0.014209069,0.039130215,-0.0028393797,0.04101652,-0.061978176,-0.05819091,-0.07011286,0.0056688916,-0.11782662,0.042926922,-0.050070755,-0.010377544,-0.016605614,0.015352046,0.04120661,-0.020883141,0.017205294,0.0027109985,0.08375619,-0.079047605,-0.064837866,0.008645919,-0.029065577,-0.028336266,-0.00532813,-0.012919812,-0.023539493,-0.0873539,-0.03864968,0.005539702,-0.028965728,-0.017144633,0.04133108,-0.03202557,-0.011270073,0.046478577,0.025590857,0.020722935,0.0010086168,-0.07878019,-0.07601954,-0.037587382,-0.017917193,-0.07393942,0.02214707,-0.04756764,0.01994181,0.022245316,0.11051826,-0.06135369 +2.5.1.115,"Requires Mg2+ for activity [3]. Involved in the biosynthesis of the vitamin E tocopherols. While the enzyme from the cyanobacterium Synechocystis PCC 6803 has an appreciable activity with geranylgeranyl diphosphate (EC 2.5.1.116, homogentisate geranylgeranyltransferase), the enzyme from the plant Arabidopsis thaliana has only a low activity with that substrate [1,3,4].",384,1.0,-0.12914419,-0.03378215,-0.08077846,-0.0091839945,0.046448633,0.03386376,-0.06503882,0.04409353,0.004885772,0.045482907,0.056498982,-0.02211719,-0.03312099,-0.0023350306,-0.013717011,0.011179534,0.004551756,0.0618051,0.015578696,0.0048016324,0.053605206,-0.010547255,-0.034181893,-0.0015275611,0.04430021,-2.4373132e-05,-0.008013584,-0.0021177402,-0.04098388,0.037921906,-0.090422705,0.015144383,0.031730387,-0.03626707,0.046366543,0.14510293,-0.0021264402,-0.09555405,0.017695801,-0.01725664,0.07212145,-0.0239471,0.027325943,0.015203347,-0.020465646,0.005481912,0.04203225,-0.047603596,0.015098224,-0.04629323,-0.045706704,0.033134095,-0.025875485,-0.06463713,0.013452387,-0.0046684155,-0.08308622,-0.018228805,0.032440275,0.067189544,0.03287468,-0.04202949,-0.038013037,-0.0152143845,0.09512952,-0.057601117,0.030137664,-0.0516191,0.03998295,-0.027728623,-0.071581304,-0.05021056,-0.009518612,0.035088096,-0.048416957,0.09270093,0.006914163,-0.0023293982,0.0100019835,-0.0686023,0.058229692,-0.020715898,-0.052548055,0.050898477,0.012936832,-0.04755495,-0.0230366,0.09143835,0.07166632,0.082774386,0.10479364,0.046716426,0.040550962,-0.08979591,-0.078423806,0.09530938,-0.017484365,-0.01883853,-0.047063395,-0.013005619,0.01877888,0.08241362,-0.007742239,-0.027781622,0.02133017,0.005295834,-0.026179388,0.08874439,0.008152893,0.057426333,0.007929375,0.022511961,-0.066742904,0.010349033,-0.038720004,0.033244144,0.022419715,-0.04665043,-0.08958416,0.056536134,0.02528973,-0.03366855,0.026445977,0.04835073,-0.02777374,-0.020916196,-0.04164748,5.6614523e-33,0.04219857,0.017647982,0.025563417,-0.011250798,-0.053109102,0.040579215,-0.06280222,0.030519413,-0.020265212,-0.042177364,-0.08577292,-0.05845645,0.028494446,0.07146062,-0.097230434,-0.023667501,-0.024193635,-0.0013840628,0.12251409,0.011640474,0.004732266,0.028194724,0.016475664,0.014618358,-0.009235425,0.028134242,-0.060825497,-0.062421855,0.070957184,-0.019399777,0.06422914,-0.12613976,-0.058626775,0.022175461,0.10405753,-0.07859044,-0.020631375,-0.065046735,-0.0018055749,0.007706585,-0.07834302,0.040490773,-0.015832534,0.010736418,0.015871797,0.0086913025,0.029601118,0.044980068,0.023175241,0.0017217222,0.074417084,-0.015874801,0.026576431,-0.006296235,-0.04633853,-0.007365287,0.021851573,0.062925346,0.05155068,0.04892957,-0.020018686,0.059943832,-0.013393351,0.016969804,0.06764176,0.029389795,-0.13023321,-0.0496258,-0.03362033,0.0782468,0.036801074,-0.08539048,0.041117527,0.11484235,-0.010496485,0.005041057,-0.060858995,-0.01936219,-0.0130794365,-0.018631665,0.0031701096,-0.06862016,0.0154647315,0.028939867,-0.0765554,0.025734177,-0.05976909,-0.035198998,0.01566239,-0.005037877,0.087510385,-0.011414353,-0.039350078,0.010219546,0.035778552,-6.233086e-33,0.08453667,-0.023917895,0.025533715,-0.06409524,-0.043375544,0.07810626,0.036436852,-0.08785031,-0.05224912,0.016690876,0.10766037,-0.029344667,0.022482371,-0.07849412,-0.03871156,-0.010333827,0.01539637,0.15782157,-0.00992298,-0.00460004,-0.038414463,0.04588913,0.05683697,0.013603375,0.01931682,0.0038991463,0.021828081,0.047891427,-0.008354364,0.047720704,-0.031833377,0.046974875,-0.061006315,-0.03513333,-0.015606474,0.035655018,-0.05498578,-0.014464535,-0.01719341,0.045131687,0.028011393,0.036885466,0.015243603,0.050790932,0.03430182,-0.0037823196,-0.02478556,0.086717226,0.0061887195,-0.010478279,0.016272273,0.016977364,-0.05426176,-0.00032969422,0.07549779,0.01846628,0.06852814,-0.05192568,0.04255498,-0.08012578,0.002202834,-0.06415366,-0.032763887,-0.07319663,0.08041051,0.1356585,0.068725795,0.12261329,0.0070205797,0.011157852,0.087594494,-0.06327085,0.06892057,-0.07487311,-0.039671846,0.035586927,-0.016500484,-0.076548226,-0.005076376,-0.09970808,0.01498928,0.01437319,-0.002008562,-0.014429155,-0.029586218,-0.062428217,0.050855797,0.086145446,-0.0014225814,0.018208146,-0.036583573,-0.007559197,-0.04628865,0.09646021,0.083358265,-4.9054616e-08,-0.011685989,-0.044378284,0.062465757,-0.074464545,0.013207915,0.050449237,-0.0029545058,0.032032933,0.086198285,0.030217996,0.03228748,-0.036629952,-0.012218576,-0.0013062817,0.07547813,-0.04606492,0.01830147,0.08022988,-0.040329732,0.014090257,-0.063528724,-0.08483951,-0.113787815,-0.008513516,-0.027834252,-0.08447176,-0.021540534,0.07988886,0.045393556,-0.052844986,0.018236654,-0.05466243,-0.03448667,-0.015878169,-0.0652093,0.029337602,-0.07164093,-0.064046904,-0.052592784,-0.02281805,-0.11291969,-0.020743432,-0.059896603,0.06210449,-0.06859292,0.013213773,0.004072803,0.059928603,-0.035329808,0.051748056,0.023846226,-0.030110776,-0.019880366,-0.09897646,-0.06911695,-0.03604667,0.011338875,-0.03357004,-0.08384594,-0.049174577,0.020764563,0.004848946,0.064475,-0.05167739 +2.5.1.116,"Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].",384,1.0,-0.095517896,-0.09055874,-0.0945484,0.009635466,0.080967605,0.060434204,-0.07944247,0.033295453,0.009813322,0.014327017,0.050881587,-0.002771662,-0.02826664,-0.028053816,-0.0212222,-0.00899349,0.014625505,0.06417119,-0.013780527,-0.03566049,0.026485436,-0.027178563,-0.003556581,-0.015404478,0.052799664,-0.022394408,0.040694267,-0.0065473886,-0.033658706,0.050167616,-0.07671381,0.01749635,0.044600423,-0.07650063,0.015213518,0.17126107,-0.019233797,-0.09278326,0.013926364,-0.05283579,0.01317359,-0.03462165,0.042439207,-0.006870344,0.03643498,-0.010697679,0.042964146,-0.03416455,0.024062974,-0.043042943,-0.041833952,0.034711976,-0.035159,-0.06963519,-0.000759301,0.00733211,-0.08659917,-0.016622707,0.016069114,0.07425362,-0.015632262,-0.016771708,0.0055655926,-0.0096892165,0.09700536,-0.030768558,0.023315338,-0.06623825,0.038106598,-0.0644798,-0.056749474,-0.057216547,-0.011761144,0.04562878,-0.039545927,0.076302126,-0.026075132,-0.026497222,0.009336055,-0.07730216,0.032030854,-0.014737012,-0.034511175,0.07207323,0.0116624795,-0.05504455,0.009047315,0.068948895,0.04740253,0.07304995,0.1144223,0.03472203,0.017857676,-0.015615003,-0.028958352,0.049374025,0.0018890848,0.008286284,-0.069084294,-0.02120014,-0.008568892,0.08076669,-0.04213021,0.0002121787,0.01699158,0.0023883188,-0.026243407,0.08537554,0.017208919,0.046367638,0.0655996,-0.0025754548,-0.052258197,-0.00030297902,-0.022510424,0.020040248,0.023571791,-0.093979865,-0.099618256,0.06574366,0.03988098,-0.002327209,0.038777277,0.055348888,-0.025805155,-0.033231534,-0.012303653,2.9058498e-33,0.012097306,0.034955196,0.043323398,-0.023289548,-0.045378786,0.027539015,-0.08209157,-0.0061537325,0.03623517,-0.070813395,-0.081208244,-0.047424924,0.014531266,0.07061334,-0.028810171,-0.040829293,0.016129024,-0.021042842,0.1252661,0.0802233,-0.035049763,0.031772114,0.026941786,0.02794106,0.032062013,0.027578335,-0.009134727,-0.042212192,0.056495275,-0.025975268,0.10242588,-0.1231112,-0.0652434,0.04591384,0.09173305,-0.03586332,-0.029789567,-0.037121817,-0.013831487,0.052004367,-0.048171867,0.042135764,-0.009330255,-0.0014096214,0.034913935,-0.01662869,0.05099865,0.0670227,-0.010559442,-0.014067275,0.058973644,0.035273053,0.0667079,0.03571137,-0.023547055,-0.03863049,0.02418937,0.041028883,0.031452708,0.085011855,-0.004856609,0.05738426,0.020724645,0.045632813,0.023736866,0.0032053788,-0.14362945,-0.049722835,-0.022778569,0.04877282,0.03915076,-0.05952268,0.04660947,0.08556681,-0.010172119,0.01064991,-0.07588944,-0.00042276608,-0.03452862,-0.047223456,0.01157186,-0.04378854,0.036846835,0.038976606,-0.11072818,0.04495741,-0.09041165,-0.028434966,0.031159883,-0.038269725,0.058354836,0.008939881,-0.051830847,0.036311507,0.0347138,-3.4872774e-33,0.0632836,-0.028696619,0.023003807,-0.044743203,-0.048198547,0.0773686,0.035122763,-0.1261845,0.023854034,0.04880918,0.12659256,-0.02947468,0.017694741,-0.12102095,-0.006402183,0.016742896,-0.0029696182,0.20348565,0.002492239,-0.02368789,-0.03335654,0.05867218,0.033142857,-0.0077146553,0.046033207,0.02926509,-0.0195559,0.0258615,-0.0018959551,0.020699134,0.018802345,0.028637115,-0.07051102,-0.0050086197,0.02136956,0.047694292,-0.039002053,-0.04708819,-0.01613569,0.10285995,0.03860918,0.03993717,0.049544863,0.0140770655,0.020283617,-0.0014972927,-0.046500895,0.09421147,0.016837291,-0.027686276,0.08786183,0.002629984,-0.04224828,-0.011700694,0.08786631,0.017054234,0.03926105,-0.017372057,0.018773818,-0.08722126,0.022007326,-0.034727775,-0.013185832,-0.043338124,0.025580121,0.061627906,0.009158597,0.124490604,2.603325e-05,-0.009264685,0.07433343,-0.07450323,0.077528305,-0.029158415,-0.032065764,0.050847955,-0.004575833,-0.05734293,0.06421589,-0.06976646,-0.01107975,0.0034286424,0.03335704,-0.022410655,-0.03732709,-0.0627705,0.02146197,0.05353181,0.012035528,0.014444775,-0.021644115,-0.071953855,-0.050927825,0.048931286,0.05822516,-4.2351697e-08,0.02626011,-0.0762686,0.023061525,-0.06277203,0.0043613072,-0.010521594,0.050411213,0.0352891,0.09218545,0.029507156,-0.00036126233,-0.029852353,-0.03616633,-0.006617684,0.053610936,-0.025841344,0.002763423,0.069863446,-0.03884886,0.0065141716,-0.060390238,-0.10909361,-0.1043505,-0.021806354,-0.027620068,-0.10418578,-0.050510287,0.054008078,0.02025777,-0.026706666,0.015026957,-0.07452104,-0.05438798,-0.06242672,-0.05292957,0.041174658,-0.0542176,-0.033697378,-0.047998063,0.03835793,-0.10945751,-0.09828076,-0.017625103,0.024313902,-0.025647972,-0.0069551356,-0.01696477,0.063284904,-0.034623966,0.026777584,0.007984401,-0.027790517,0.012922464,-0.100339495,-0.05701381,-0.01954112,0.026054598,-0.061547313,-0.05182502,-0.062800676,-0.001712074,0.036305014,0.08992757,-0.063673906 +2.5.1.117,"Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10 to C20 prenyl diphosphates, producing main products that are not decarboxylated [2].",384,1.0,-0.11849616,-0.07754528,-0.030575544,-0.0518515,0.024730146,0.05305525,-0.067982204,0.023271281,-0.073936775,-0.018091595,0.05605913,-0.017407201,0.032706335,-0.046317123,-0.019966077,0.050381232,-0.06572616,0.06431352,-0.031941585,-0.03462008,0.113709204,0.020584581,-0.0218938,0.008483858,0.08194122,-0.0061916383,-0.027139992,0.0045267595,0.029248038,-0.02134519,-0.040154886,0.01766745,0.007895229,-0.09879896,0.02287238,0.14676137,-0.0066425125,-0.06660621,0.027691085,0.010796872,0.06366647,-0.07765688,-0.021955444,-0.0043801237,-0.029008992,-0.052404273,0.117859475,0.044287615,0.0022746634,0.013293082,-0.033942737,-0.04080887,-0.06716506,0.045037135,0.085914776,-0.009091116,-0.052013963,0.04886971,-0.024362762,-0.0240431,-0.019669315,-0.011911775,-0.0075358995,0.023565518,-0.016239759,0.0204047,-0.051062178,-0.046334986,0.042669956,-0.0016636979,0.019706596,-0.05526819,-0.010460843,-0.03573784,-0.058757853,0.10776811,0.003786296,-0.032508686,-0.022952057,-0.0014018194,0.0531988,0.0024175888,0.045596927,0.06112873,-0.018973567,-0.045752663,0.036811326,0.039871883,0.031774376,0.05066841,0.076770864,0.027680483,0.008268185,-0.02195954,-0.108245656,0.10083814,0.0039057739,-0.033768713,0.022764536,-0.019409139,0.009005242,0.02923817,-0.027307509,-0.07574138,-0.040556267,0.03843897,-0.088157944,0.031562068,-0.07434674,-0.0011509156,0.022692014,-0.020169096,-0.049796503,0.048013795,-0.02395999,0.041561455,0.017184699,-0.097635694,-0.060673997,-0.04268645,-0.029639171,-0.008328456,0.038126323,0.01150636,-0.070126005,-0.00035313217,-0.12136329,5.366927e-33,-0.028865421,0.02068366,-0.0122229,-0.06143971,-0.039510183,-0.017984953,-0.0952573,0.062852055,-0.024218736,-0.05174964,-0.04199293,-0.07510281,0.0068127266,0.035896562,-0.010255587,-0.05854143,0.006575404,0.0131765045,0.05595994,0.0056192703,-0.022729803,0.07417724,-0.05689625,-0.041299745,0.004442356,0.10504071,0.0034393354,-0.064040095,0.06678752,-0.037843075,0.06516325,-0.08342262,-0.0112429,-0.025190197,0.072715074,-0.026389247,-0.08116683,-0.06293643,-0.05607782,0.044810712,0.002424796,0.013674705,-0.06890135,-0.017558582,0.11357099,-0.042215683,-0.040463958,0.061322443,0.026192365,0.027970633,0.06008112,0.09243839,0.0849215,0.0043113767,-0.06998907,-0.007019905,-0.023178706,-0.0050011897,0.019649059,-0.00036400833,-0.044837534,0.02100104,0.02227195,0.021585474,0.0044007935,0.015049814,-0.11526873,-0.027415726,0.017945444,0.08331301,-0.0016326145,-0.058269937,-0.044092663,-0.0108827455,0.085232876,-0.0031115187,-0.008604106,0.044391986,-0.0008922862,0.0048510395,0.050959367,0.0067492374,0.013896511,-0.019333864,-0.034798987,-0.015611097,-0.046586465,-0.002222836,-0.009215053,0.060572304,0.086244665,-0.00558826,-0.019230587,0.041838016,0.015878154,-6.1806e-33,0.10035017,-0.064037964,0.0953364,-0.078737944,-0.08161142,0.053739842,-0.0174355,-0.06683013,0.034813512,0.053101297,0.019857364,-0.011500792,0.023141814,-0.04698113,-0.027294176,-0.033790722,0.024014007,0.1713236,-0.021128278,9.861902e-05,-0.006776262,0.10264441,0.03285234,0.035582397,0.044407893,-0.019480018,0.015488806,0.06292976,0.034973055,0.0525388,0.00272212,0.0007191763,-0.0766449,-0.013791843,-0.061759353,0.00738003,-0.009120543,0.056022752,0.044737484,0.07987265,0.08597367,0.023219805,-0.022869142,0.039029557,-0.013414788,0.034812156,-0.06742067,0.091991924,-0.033486415,-0.055838276,0.021620417,0.024627585,-0.03579706,0.012683566,0.10396364,0.026059411,0.013075378,-0.040103666,0.068328045,-0.047527794,-0.008720889,-0.098319,-0.0073097674,-0.040297944,0.061242014,0.071545884,0.04078712,0.03398971,-0.07388862,-2.7207374e-05,0.083311215,0.052572854,-0.024323061,0.03439412,0.00038326695,0.07089482,-0.041246254,-0.095472515,-0.006346885,-0.040004015,0.015999496,0.004555766,0.012019619,-0.032461844,0.0038565816,-0.0814683,0.020819778,0.09087532,0.029337032,0.023547025,-0.008412337,-0.029204462,-0.014364746,0.09208172,0.076269865,-4.04856e-08,0.0002626952,-0.049164344,0.045411583,-0.05658225,-0.010325621,0.020732041,-0.022729667,-0.013492757,0.06570611,-0.024964264,0.011545488,-0.04730649,0.04350771,0.0247406,0.08798897,-0.025163326,0.049771447,0.02376348,-0.022964481,0.02087371,-0.07788618,-0.060053293,-0.09259328,0.09627073,0.0051471824,-0.0844078,0.045790084,0.05799346,-0.0057421136,-0.0064126276,0.027443698,0.0050843996,-0.0017688345,-0.09136424,-0.08077042,0.013739326,0.024081064,0.0009764533,-0.020542083,-0.046435203,-0.05880691,-0.048399307,0.040332876,0.0029270835,-0.03365698,-0.05708936,0.00857957,0.021376064,-0.022017546,0.034305017,0.045939997,-0.027769232,0.037907466,-0.16390374,-0.059066653,-0.06387647,0.026184034,-0.04975939,-0.08191757,-0.03433087,-0.0029647192,0.029764228,0.17643577,-0.058846515 +2.5.1.118,"The enzyme from the plants Lathyrus odoratus (sweet pea) and L. sativus (grass pea) also forms 3-(5-oxoisoxazolin-4-yl)-L-alanine in vitro (cf. EC 2.5.1.119). However, only 3-(5-oxoisoxazolin-2-yl)-L-alanine is formed in vivo. 3-(5-oxoisoxazolin-2-yl)-L-alanine is the biosynthetic precursor of the neurotoxin N3-oxalyl-L-2,3-diaminopropanoic acid, the cause of lathyrism. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, beta-pyrazolylalanine synthase.",384,1.0,0.0045464695,-0.08161986,0.004386499,-0.020364404,0.09179406,0.10782076,-0.080248006,-0.0048259036,0.072388776,0.049969025,0.0450885,0.0034224284,-0.004889058,-0.0013262536,-0.0026107419,0.09637489,-0.094574966,-0.008669737,-0.020981776,-0.06718023,0.052196424,0.05829353,0.032197442,0.020221263,0.031622056,-0.0065653953,-0.03031933,0.043953534,-0.02688685,-0.07709246,-0.03326291,-0.07246173,0.026520967,-0.058434617,0.0012090167,0.026705168,-0.0717011,-0.11097348,0.025347842,0.052812297,0.032857426,-0.040815838,-0.05600215,-0.008902991,-0.05092303,-0.06017912,-0.0573537,0.009210332,0.036783442,0.00087694236,-0.034784183,-0.071339644,0.012180186,-0.007952448,-0.04576149,-0.009194768,-0.03789377,0.08549964,-0.05596138,0.034316003,0.021275187,0.0656631,0.00022014235,-0.052810136,-0.02949858,0.03109986,-0.029767672,-0.07787797,0.05393072,-0.012710892,0.0021352125,-0.13320106,-0.009599264,0.0039106174,-0.032850217,0.049547337,-0.030614333,-0.020084469,-0.048469592,-0.050204992,0.08362132,0.048333894,-0.073768616,0.084796034,-0.008219716,-0.037146468,-0.04347201,0.04896692,-0.00922084,-0.018754207,0.07194111,-0.051876456,-0.014172897,0.022290621,0.06322582,0.034903042,0.0007787558,0.031042233,0.01429525,-0.042909,0.0063790954,0.033230245,-0.06973842,-0.009912086,0.07010289,0.09315224,-0.02943932,-0.027722565,-0.02199046,-0.045844257,-0.0064467853,0.0059928386,-0.022923727,0.047972914,-0.05613132,0.074970044,0.022305368,-0.0298357,-0.07797236,0.0057899854,0.070431605,-0.03860914,0.061242945,0.01917984,0.044115696,0.032775104,-0.15829672,4.6396555e-34,0.051826395,0.046477284,0.0023769515,-0.018138582,0.07643228,-0.04593088,0.024021985,0.06396287,0.056735158,-0.013581846,-0.11196,-0.024601704,0.059661586,-0.041409142,-0.044931997,0.01752813,-0.07394554,-0.021155,0.08842906,0.031008838,-0.018817086,-0.037074205,-0.048823614,0.01513507,-0.08915125,0.012565675,0.03413279,-0.005822931,0.054602515,-0.01172427,0.0062294584,-0.1045603,-0.038036704,0.016311234,0.06380046,0.008976102,-0.0031537376,-0.040878214,0.015199302,0.04131617,0.006690466,0.039945573,0.058014106,-0.012911389,-0.0044465857,0.0028043683,-0.116551474,0.07222444,0.10723755,0.033154152,0.10336114,-0.017191483,0.087901026,0.0275557,-0.028640395,-0.023322362,-0.072155125,0.024802815,-0.021998554,0.02374517,-0.0071521085,0.0076358495,0.03165831,0.0047236797,0.0041617374,0.0060301805,-0.045712408,-0.064400084,-0.022681465,0.04337865,0.025439184,-0.08038676,0.0049527427,0.0285321,0.063324794,-0.041592337,-0.07479418,0.04608972,-0.0035382197,-0.017922474,0.016583176,-0.0051786443,-0.0207158,0.0579564,-0.061327532,-0.031164398,0.028563507,0.020610984,0.050620224,0.05681879,0.04910212,-0.034089237,0.0019615348,0.007633551,-0.054140497,9.939879e-36,0.032756295,-0.06257704,-0.0032908048,-0.019619243,-0.029197136,-0.005464022,0.0185025,0.073544495,0.023907498,0.02927994,0.109094284,0.04816545,0.022582373,-0.025055481,0.01801466,-0.0039182655,-0.027022395,0.093888916,0.03179957,-0.013874185,-0.01258567,-0.0045125834,-0.0016631252,0.052801672,0.07490416,0.033227284,0.03603811,0.053962156,0.008717637,0.049721085,0.007852037,0.040298674,-0.058441535,-0.04347582,0.03953117,0.07076671,-0.030481124,-0.018391788,0.023718666,0.03782392,-0.028346512,-0.0059451847,0.0945178,0.008620711,0.08524206,0.017216314,-0.059495203,-0.031348623,-0.039237052,-0.015011235,0.0587717,-0.020566242,0.010835379,0.06293877,0.017761728,0.059963755,-0.0136347,0.050535984,0.020448247,0.026556369,0.038339306,-0.031727757,-0.057411987,-0.025123062,0.009812546,0.026873028,0.008983433,0.04194541,0.02504399,0.0679668,0.013916654,0.041406937,0.028991494,0.06839402,-0.07943476,0.0047829454,-0.06255942,-0.0558622,-0.013696599,-0.08030277,0.044978846,0.019754764,-0.005717425,-0.03912833,-0.046111047,-0.060796723,0.03230087,0.19616953,-0.02323473,0.02401264,0.012634884,-0.0704056,-0.11388537,0.052638702,0.09073213,-4.5999673e-08,0.0477455,-0.036140006,0.01936154,0.0030587653,0.041366827,-0.006941057,0.04001522,-0.0037782413,0.05666918,-0.048525162,-0.038147815,0.04987839,-0.02913114,0.0070461254,-0.0026181769,-0.030347105,-0.008968444,0.11520425,-0.01666428,0.019118717,-0.027563864,0.035248253,-0.13750082,-0.053900067,0.04408952,-0.08526494,0.054040063,0.03646949,0.047842793,-0.017402194,0.06402003,0.029887917,0.03178045,-0.091119945,-0.08648472,-0.030741028,-0.022102937,-0.0470354,0.013619837,-0.074700154,-0.108515,-0.0381202,-0.08893877,-0.02830709,0.05355174,-0.11173235,-0.033520922,-0.017545465,0.022448879,0.009477277,0.06430761,-0.005481175,0.030066269,-0.09036852,-0.060397033,-0.04427283,-0.002773775,-0.019090174,0.022635885,-0.10615176,-0.07210324,0.050374437,0.20724583,-0.0046362607 +2.5.1.119,"3-(5-Oxoisoxazolin-4-yl)-L-alanine is an antifungal antibiotic produced by the bacterium Streptomyces platensis. The enzymes from the plants Lathyrus odoratus (sweet pea), L. sativus (grass pea) and Citrullus vulgaris (watermelon) that catalyse EC 2.5.1.118 (beta-(isoxazolin-5-on-2-yl)-L-alanine synthase) also catalyse this reaction in vitro, but not in vivo. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, beta-pyrazolylalanine synthase.",384,1.0,-0.0258007,-0.036209904,-0.098360546,0.006753384,0.09951264,0.09611729,-0.048950497,-0.01678286,0.090435155,0.025690913,0.0072160396,-0.02481841,-0.023298569,0.0059083793,-0.046469245,0.06481551,-0.06373697,0.011031447,-0.020434981,-0.08508747,0.05204292,0.08376255,0.035048746,0.036727183,0.048796937,0.045475483,-0.02578967,0.037473988,-0.05550219,-0.11296837,-0.016398722,-0.068258226,0.10089066,-0.07339354,-0.005429053,0.024357527,-0.054906588,-0.12863553,0.071152434,0.049381506,-0.033257175,-0.01369038,-0.017182741,-0.024051158,-0.082452565,-0.022834796,-0.0103191575,0.027775314,0.06187284,-0.039394286,-0.04580816,-0.07521847,-0.01779114,-0.029566491,0.011559476,-0.012805654,-0.06018071,0.003605499,-0.034430202,0.003096452,0.0796015,0.028185522,0.0019149343,-0.013507202,-0.11270323,0.03378148,-0.053837273,-0.1180791,0.03647991,-0.015581204,-0.10156548,-0.10192946,-0.046142098,0.021083502,-0.0022906847,0.081043735,0.020494858,-0.06846118,-0.065646864,-0.008281988,0.04529644,-0.017285304,-0.058429807,0.013154167,-0.0097469585,-0.037416708,-0.008827989,0.044012748,0.06281871,0.008693354,0.10493318,0.014242495,0.016785974,0.04065586,0.014102989,0.036214784,-0.007265138,0.048148748,-0.0068814117,-0.013626227,-0.022993965,0.05945115,-0.06265801,-0.022060432,0.028385475,0.022887522,0.009511298,0.074235596,-0.014715069,-0.073088475,0.009074802,-0.04002465,-0.041196708,0.042676523,-0.029449813,0.044598278,0.09335968,-0.038912248,-0.06475381,0.002847798,0.09777903,0.0019360824,0.06138083,0.0068484596,0.020529924,0.03084395,-0.15305488,1.0860728e-33,-0.0021320789,0.098627016,0.008872166,-0.006465757,0.056179017,-0.0066716536,-0.05698752,0.06803521,0.051895574,-0.037987426,-0.10090366,-0.010576353,0.037678227,-0.00443941,0.0041748653,0.016576817,-0.03346315,0.01491341,0.07216684,0.04191541,0.0029081122,-0.040444326,-0.07491502,0.01831676,-0.0104840165,0.05695952,0.07521253,0.026322423,0.10410285,-0.015387993,-0.013463264,-0.040860947,-0.055504654,-0.022720609,0.051923797,-0.0028262683,-0.052334275,-0.019658731,0.039460376,0.0573689,-0.005290424,-0.0077832094,0.02007998,-0.005580682,0.02502565,-0.014243498,-0.085771844,0.09249408,0.08428488,0.021411296,0.07964039,-0.015743515,0.10412143,0.053612575,-0.023954397,0.00685637,-0.058961403,0.093483776,0.009637866,0.052064877,-0.033941336,0.07267871,0.016475964,-0.0012318628,-0.042389907,0.0020488012,-0.03438359,-0.07805828,-0.029010706,0.05094644,-0.014509517,-0.00049681816,0.037853494,0.02183597,0.0373724,-0.046652142,-0.11197387,0.015283663,0.06986692,0.03809181,-0.043327983,0.02530571,-0.011247847,0.004382636,-0.067337684,-0.028149465,-0.021500077,0.021613602,0.043025613,0.07989613,0.01522213,-0.06666875,-0.03901421,0.042906832,-0.013521679,-1.858243e-33,0.0887456,-0.12476717,0.028685473,-0.043462377,-0.038845062,0.029429357,0.009460299,-0.0072621545,0.04420768,-0.012741511,0.09026111,0.025239749,0.021987528,-0.044307753,0.05533156,-0.07485097,0.024996193,0.029389761,-0.016890062,0.0154174045,0.036848255,0.03559849,0.029606298,0.034782335,0.069796495,0.00037672243,0.057972293,0.049759302,0.01680168,0.056968052,0.013767972,-0.021162707,-0.012479009,-0.085912555,-0.049676113,0.11712794,-0.012837612,-0.0030213024,0.05010682,0.023121767,-0.0038424176,-0.0045037186,0.0016208948,0.041579686,0.036149144,0.11004793,-0.03964779,0.0050418386,-0.015148438,-0.037611887,0.034009356,0.019047726,-0.0380076,0.009736984,0.03331275,0.016125824,-0.03250866,-0.0011276297,0.026473813,0.011039191,-0.024362281,-0.045829188,0.033164512,-0.023681045,0.023900194,0.038154364,0.009983973,0.06482157,0.09695238,0.025155332,0.07354126,-0.012699834,-0.016001688,0.07222396,-0.058440764,0.0074598915,-0.015274406,-0.055674374,-0.010369445,-0.051846337,0.022276375,-0.02428826,0.024117101,-0.009916866,-0.04889075,-0.102466114,0.04923806,0.15079574,-0.06914109,0.06279052,-0.026377661,-0.022949332,-0.06497744,0.066664666,0.08157887,-4.5238465e-08,0.030417899,-0.05930129,0.03712107,-0.058987826,0.030137405,0.021501794,0.019310271,0.013349508,0.07880921,-0.040280372,-0.05674989,0.017488306,0.01706433,0.029858038,-0.020553812,-0.026237452,-0.04835793,0.05290715,0.016670948,-0.006354305,-0.07384401,0.03372385,-0.14783812,-0.056062773,0.03222669,-0.10038836,0.044019375,-0.0011821415,-0.027224507,-0.010165648,0.036046896,0.029474795,0.007621786,-0.0061854,-0.07628796,-0.050842583,-0.037841164,-0.05042125,0.003998386,-0.042708524,-0.06478067,-0.04905035,-0.1069636,-0.025065208,-0.030747699,-0.04580128,-0.036483057,-0.0024075615,-0.028446935,-0.048056945,0.09022665,0.020063005,0.011682669,-0.046964686,-0.05125812,0.0013246618,0.00443401,-0.08541135,-0.023886792,-0.036936138,-0.028769383,-0.03682802,0.20091848,-0.0023563094 +2.5.1.120,"This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.",384,1.0,-0.073761486,-0.04904737,-0.16328156,0.053423475,0.019464519,0.031687338,-0.07881029,-0.011968926,0.051930677,0.037331954,0.048471924,0.012312568,-0.04938388,0.026759364,-0.017377073,0.11349473,-0.14193243,0.007957922,0.012744993,-0.012208406,0.06075314,0.031974442,-0.025888368,-0.052973125,0.09470927,0.020542745,0.031200808,0.011975053,-0.01680594,-0.0029781247,0.096956946,-0.028625881,0.07955659,0.0037291525,0.023826992,0.10864588,-0.040363017,-0.023880588,0.096790284,0.030196847,-0.006093561,0.0069067283,0.05054203,-0.008747354,0.011631215,0.003170414,-0.0039276606,0.051508773,0.05775925,0.020545036,-0.048827913,-0.044423673,-0.04533922,-0.0025380899,0.06890463,0.047251694,-0.0037161373,-0.025955372,0.0011115142,-0.010751833,0.07794117,-0.02252236,-0.038561795,-0.019154098,-0.03408363,-0.053301223,0.028180437,-0.0478271,0.050532572,-0.03418033,0.008685261,-0.061670873,-0.01507458,0.03037948,-0.03090077,-0.0076208944,-0.03191749,-0.02506973,0.019319672,-0.02611656,0.07124013,0.012070621,-0.011495076,0.07628624,0.07334972,0.03097512,-0.014186455,-0.016308516,0.006066871,0.055014066,-0.054245867,-0.0637828,-0.008147073,-0.10479053,0.014042655,-0.03365367,0.01338854,0.05294371,-0.07472534,-0.010873804,-0.013045642,0.04896403,-0.056658544,-0.088309065,-0.07108098,0.002606567,-0.021597382,0.07994578,0.023187,0.020441744,-0.033305783,0.08177406,0.017453723,-0.035273097,0.009618238,0.046018973,0.034030855,-0.051264144,-0.06438989,0.047234964,-0.017199636,0.03886792,0.03836313,0.09728007,0.01989409,0.02943144,-0.10025876,7.4694745e-34,0.0668176,0.09135788,0.009211914,-0.04861007,0.0012106223,-0.056654677,-0.06250527,-0.0530493,0.0039002213,-0.024196835,-0.09719695,-0.03872863,0.029212635,-0.03941219,-0.06525131,0.002511877,-0.043838628,-0.02511951,0.036126144,-0.045231257,-0.11433401,0.0145372795,-0.08404427,-0.055243712,-0.013013302,0.010660291,0.025163807,0.0042836983,0.042406447,0.023686042,-0.07625066,0.015211654,-0.11141951,-0.0036972626,0.01130132,0.022822294,-0.092253014,-0.12721652,0.015114489,0.0671679,0.051278733,0.016992198,0.014453495,0.023927564,0.044774164,0.0218745,-0.058562335,0.060541335,0.09591158,0.061048515,0.01564818,-0.035443008,0.104640454,-0.009878127,-0.0765679,-0.045587253,0.008073179,0.03293036,0.014521,0.11526012,-0.0029900898,-0.04438407,-0.030401815,0.059560888,-0.052601587,-0.020774852,-0.05277206,-0.060251135,0.020605093,0.1165881,0.008069599,-0.0020932024,0.05503135,0.037017368,-0.0074051837,-0.0037961088,-0.014309538,0.07956799,0.008070413,-0.035339113,-0.035674363,-0.054109976,-0.023690408,-0.04762848,-0.023508526,-0.0017325768,-0.019748073,-0.06299817,-0.05812455,0.004694089,0.017802246,-0.08766588,-0.031549785,0.043085735,0.053890195,-1.8360076e-33,-0.032486204,-0.05681682,-0.0053262278,-0.08005643,-0.046931997,0.057853226,-0.014036349,-0.0108597325,0.006119195,0.0047537824,0.041904878,-0.050992772,0.04753685,-0.07545802,0.030968657,-0.040275056,0.06996116,0.034197453,-0.0048671593,-0.031210419,0.043148436,0.076577894,0.049757283,-0.02122392,0.048029117,-0.0041323206,0.001754971,0.078206174,0.057448275,0.088773586,0.029884364,0.043440428,-0.08382922,-0.05712458,0.023929754,0.065534286,-0.027665416,0.038576283,0.012604403,-0.00061228673,0.042924672,0.0775821,0.042717487,0.15298498,0.047049053,0.09382967,-0.02469761,0.044740163,-0.031833693,-0.119030334,0.0066463733,-0.022073384,0.023083318,0.0049175033,-0.0030708362,0.06958677,0.02239322,-0.024002142,-0.041252583,-0.08378511,-0.098979995,-0.04773677,0.0039377664,-0.04118568,0.003722792,0.014704021,0.033976097,0.012771702,0.022735806,0.023399854,0.028234705,-0.0151464185,0.021840101,0.09701457,-0.07155785,0.00880369,-0.08535574,-0.025860516,0.032502122,-0.02357589,-0.001660618,-0.014142425,-0.007924592,-0.010036252,-0.03141998,-0.08083037,0.047708724,0.08886295,-0.009188428,0.024073781,-0.05362266,0.0217058,-0.07800929,0.03962017,-0.006709913,-3.475993e-08,0.053308863,-0.06463771,0.045107227,-0.03121838,0.07803833,0.07208166,-0.03872984,0.056420535,0.010067594,-0.01868799,-0.079651475,0.104678184,0.005850838,0.007782608,-0.006340563,0.03499909,-0.0068149418,0.0016210059,-0.007379711,-0.052295297,-0.036655787,-0.008846017,-0.033258647,0.049910147,-0.0630213,0.014043166,0.066423304,0.07071834,0.0045975978,-0.006418305,0.055768408,0.009935489,-0.077650204,0.020014288,-0.16212893,0.014714905,-0.001138761,-0.02969718,0.026354162,0.032610122,0.019338042,-0.05917698,-0.032548428,0.08398826,-0.047616117,0.022340788,0.0034282003,0.01296609,-0.045778587,-0.022365557,0.032215666,-0.052806336,-0.02613403,-0.02862031,-0.12328789,-0.029095573,-0.042246968,-0.03742422,0.054770872,-0.051438108,-0.018448092,0.043003246,0.16273706,0.015337593 +2.6.1.104,"A pyridoxal-phosphate protein. The enzyme, found in the bacterium Bacillus subtilis, is involved in a kanosamine biosynthesis pathway.",384,0.99999994,-0.04130373,-0.054146666,-0.05492932,-0.04165168,0.03744663,0.020068571,-0.018367814,0.015075752,0.05631488,0.03516305,0.051714372,-0.05097752,-0.016475998,0.06947046,-0.03424421,0.054165393,-0.08935545,-0.022115083,0.04906895,-0.035700712,0.12774518,0.077197075,0.00928682,0.008079527,-0.004275655,0.036370628,0.080553144,-0.030214839,-0.023859296,-0.017684888,-0.05287897,-0.00570779,0.05044296,-0.09008168,0.08853807,0.10300518,-0.040711034,0.013867806,0.08694206,-0.007976223,0.034142252,-0.026873637,-0.0004494674,0.011437199,-0.053029105,0.051804185,0.093593106,0.011308971,0.04999099,-0.032717895,-0.08276965,0.0033331343,-0.042981204,-0.006428557,0.038068626,0.009341185,0.0074152565,-0.016305495,0.014033755,-0.03485217,0.036736872,-0.0042243153,0.043021575,-0.019772585,0.027405092,-0.06589093,0.026668658,-0.041258648,-0.02546934,-0.043927077,-0.015054583,-0.036068354,0.061728746,0.013813453,-0.020661365,0.04559381,-0.041353013,-0.032426152,-0.023448655,-0.039440617,0.026314305,-0.010050155,0.03485296,0.09189366,0.05353421,0.0076459832,0.07365911,-0.056622222,0.028979195,0.0052633495,-0.0092028985,-0.06504787,0.0245748,-0.035716236,-0.061440717,-0.030969903,0.015535029,-0.015396948,0.06285072,-0.038919598,-0.014684573,0.02137359,-0.0027453434,-0.06959469,-0.08932481,-0.0167209,-0.014211173,0.06880952,0.066302136,0.013909039,-0.0399492,0.07879917,0.0032414228,-0.00031920214,0.0109131485,0.046574842,0.07155756,-0.034884997,-0.06863449,0.053906836,-0.0021376987,-0.03248226,0.0032299256,0.11431422,-0.07267239,-0.0085004885,-0.14475977,7.3658565e-34,0.03854935,0.049805094,0.05474057,0.009737024,0.017167645,-0.045037713,-0.07530496,-0.085115045,-0.09058845,-0.09130442,-0.06442884,-0.07122117,0.042656235,0.06274757,-0.040115375,0.0001494651,-0.091649644,0.027903935,0.07293796,-0.02372423,0.0038333696,0.07966175,-0.03961303,0.015568239,-0.0007587868,0.05908089,0.035849538,-0.012604575,0.023554567,-0.007587413,0.066227004,-0.07362753,-0.10564296,-0.042280983,0.05014811,-0.07945914,-0.022352446,-0.045561675,-0.061970387,0.004253267,-0.028755108,-0.0067214286,-0.037644546,0.0022942687,0.013385169,-0.10903323,-0.016211227,0.056601007,0.014656467,0.05867743,0.0061787292,-0.018992634,0.12040356,-0.047554377,-0.10250535,0.0013578952,-0.006526313,-0.04891672,0.03174057,0.03957047,0.06257136,-0.0039588623,-0.05789531,0.027636552,-0.008514871,-0.0016066418,-0.0019031018,-0.051196285,0.08543616,0.034348156,-0.037177276,0.031844586,0.031679694,0.027272094,-0.049063735,-0.012594485,-0.076830134,0.011281407,-0.060827676,0.045364555,-0.05717292,-0.06765685,-0.022532195,-0.05607339,-0.058976837,0.01807647,-0.005482383,-0.103567444,-0.026331345,0.054071035,0.047766436,-0.117945805,-0.079643644,0.06288346,-0.021730958,-1.6797517e-33,0.10235884,-0.09292101,0.09531802,-0.0680685,-0.04898208,-0.021960689,0.08922025,-0.027836766,0.023219846,-0.00919533,0.011530333,-0.0040968526,0.029974177,-0.009728419,0.029096436,0.053425662,0.018441739,0.03546634,0.072654516,0.028295467,0.0045006587,0.071410514,-0.005177026,0.010001122,0.022038488,0.09254139,-0.026712297,0.08067203,-0.040102743,-0.026426865,-0.03860948,0.038050145,-0.0060635763,-0.06798849,-0.08773569,-0.008774337,-0.063444965,0.0011837375,0.03305711,-0.009863217,0.030236265,0.1114699,-0.0054684035,0.010634557,-0.0069488813,0.043067563,0.024994096,0.03703297,0.033405587,-0.076022506,0.014399025,0.01563669,0.035750795,-0.07289187,0.062990814,0.0237643,-0.093534775,0.07660208,0.011712948,-0.026014728,0.0007666941,-0.061556146,0.07781225,0.077854484,0.033973485,0.11967969,0.028679775,0.012281604,0.043054666,-0.022353187,0.044608813,0.05661692,0.05826382,0.08086482,-0.060448647,-0.04435665,-0.09924634,0.0025995343,0.0037422115,-0.010442965,-0.0036225063,-0.052129146,-0.031830058,-0.075707674,-0.00087143556,0.0016277098,0.06198844,0.08391603,0.017520757,-0.025497822,-0.039945606,-0.009286343,0.012108544,0.070402674,0.08737555,-3.034882e-08,0.07338435,-0.08079872,0.014731985,-0.041085895,0.010024747,0.00044373728,0.028964208,-0.010033512,0.060992412,-0.0427672,0.014309251,0.015398156,0.031046383,7.819778e-05,0.041575182,0.05459049,-0.018958798,-0.0208492,-0.0035683424,-0.05680968,-0.057877295,0.031500306,-0.09247841,0.09848221,0.06022907,-0.015886098,-0.0064238124,0.022199979,-0.014758526,-0.06708472,-0.0041454346,0.026779039,-0.024100725,-0.049235128,-0.03672903,0.07146173,-0.10497159,0.0006105325,-0.012749755,0.029786054,0.023783674,0.0063554193,-0.0171965,-0.011779106,0.0012915435,0.11020998,-0.06211918,0.039118167,-0.04380717,-0.055492394,0.04705437,0.018429045,-0.060587186,-0.0013839916,-0.15463293,0.05207011,-0.0071528265,-0.043354873,-0.028361658,-0.057182714,-0.004849286,-0.0021471074,0.13315308,-0.08736675 +2.6.1.105,"A pyridoxal 5'-phosphate enzyme [2]. Participates in the pathway for biotin biosynthesis. The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyses an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8-diaminononanoate (cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase).",384,0.9999999,-0.06544291,-0.034917794,-0.009094368,-0.04599568,-0.0008194128,0.035961818,-0.08882225,0.10686319,0.023251591,0.027119786,-0.014506559,-0.05775585,-0.05274942,0.08386033,-0.061499983,0.0022858465,-0.11329345,0.042905197,0.01932619,-0.05996592,0.12671426,0.070682876,0.00997379,0.014104472,0.059559364,0.0047131097,0.036366858,0.016912024,-0.02169607,-0.01852614,-0.051104534,-0.04838866,0.0077167437,-0.07981801,0.075704,0.12064868,-0.002871954,0.017850546,0.09310543,0.036607683,0.04105523,-0.05015544,-0.028738132,-0.03443649,-0.031947736,-0.065796755,0.047062732,-0.024802603,0.063550636,-0.030529793,-0.09936183,-0.003521069,-0.059060216,-0.041689433,0.08170865,0.004365499,0.064732194,-0.06779977,-0.0033275564,-0.042320423,0.054758944,-0.08902065,0.014287023,-0.023421813,-0.03226864,-0.07938788,0.026482366,-0.06710242,0.0081485845,-0.019586883,-0.03576581,-0.038271043,0.040531136,0.051815152,-0.0055297855,0.017110547,-0.08420632,-0.0042945733,-0.03488616,-0.024870787,0.08459707,-0.06112208,-0.0100751445,0.055081055,0.057156235,-0.00010791171,0.009252077,-0.0013667468,0.052324064,0.006018333,-0.048113633,0.03855043,0.023959799,-0.059769794,-0.062909886,-0.03735086,-0.035235956,0.044772666,-0.03069376,0.0011784306,0.030770734,0.049628872,-0.0709214,-0.032661177,-0.04720072,-0.04948846,0.0058153872,0.06619618,0.049302444,-0.01394018,-0.033768736,0.06207308,0.026469173,-0.014290258,-0.058983885,0.076348156,-0.011674123,-0.046673644,-0.07078799,0.049142357,0.013505846,0.0010591456,0.066400014,0.08402556,-0.017200796,-0.07493352,-0.0385714,3.583974e-33,0.04855118,0.04420064,0.04480346,0.0014574149,0.023533447,-0.03576637,-0.119495325,-0.040786855,0.006898131,-0.08940414,-0.0958106,-0.044319242,0.0044632563,-0.0012977907,0.00063554494,-0.015178506,-0.03220816,0.015326952,0.036890652,-0.02677626,0.06349405,-0.019487245,-0.03291848,0.11332805,0.017986028,-0.024862183,0.043578684,0.049698465,0.053987112,-0.0144735,-0.030815214,-0.07959989,-0.071832836,-0.0794836,0.027593574,-0.078748025,-0.07321104,-0.038705282,-0.007539344,0.088857085,-0.015299598,0.014112862,0.021369569,0.0033664582,0.064849496,0.008067635,-0.029510243,0.13023359,0.041214064,0.11361073,0.03781773,-0.035648398,0.06081487,-0.021310145,-0.10505433,-0.010202806,-0.009928973,-0.03643218,0.022456653,0.06710105,0.09115164,-0.011968295,0.007999367,-0.036722645,-0.055406854,0.035430066,0.015868217,-0.007827909,0.033339668,0.049881604,-0.01985663,0.045395713,0.050365552,0.11993914,-0.011670219,-0.058377765,-0.052840326,-0.009489585,-0.005782512,-0.052577965,0.0126749575,-0.0056987167,-0.035425246,-0.026689677,-0.007119893,0.015926087,-0.049081676,-0.06858229,-0.016286794,0.048360236,0.037012145,-0.13218375,-0.07596467,0.03563878,-0.04886397,-3.3189576e-33,0.08452254,-0.043667283,0.04308806,-0.043550335,-0.028944036,-0.0060287598,0.03901803,0.04501758,-0.019372877,-0.04728889,0.05586259,0.023144282,0.08750139,-0.0037520586,-0.003332677,0.0030518179,-0.006039254,0.05234731,0.06165158,0.026847882,0.053283624,-0.003927879,-0.025269883,0.004982289,0.09519977,0.090467766,-0.047682036,0.052389238,0.031858902,0.0022263236,-0.0021121895,-0.0003406186,-0.047863625,-0.010488924,-0.07327406,0.08736048,-0.015597707,0.006963177,0.025007877,0.04249891,-0.00419022,0.044268712,0.022363633,0.02290521,-0.0055334647,0.007859528,-0.012012864,-0.04029762,0.005111732,-0.07458438,0.04502018,0.035918195,0.0045437706,-0.06545641,-0.00764793,0.042975787,-7.4791526e-05,0.06932292,0.016372867,-0.031090256,0.012402122,-0.078409776,0.081426926,0.01661729,0.00894318,0.10509494,0.015096179,0.04891178,-0.011837227,-0.02181925,0.03454839,-0.0059373514,0.06840962,0.06318636,-0.017566245,-0.018561678,-0.030916965,0.01995091,-0.015442196,-0.016314983,-0.04940947,-0.030201528,-0.009006092,-0.10736483,-0.010160762,-0.035830803,0.10597531,0.043920804,0.02047978,0.025967095,-0.01423945,0.005913207,0.018990705,0.028020522,0.06921192,-4.5651113e-08,0.08595143,-0.11796546,0.025345268,-0.030606596,0.073127925,0.0025797514,-0.019875484,-0.043993615,0.070832424,-0.07683077,-0.031053482,0.021922424,-0.03533904,0.060399923,-0.01116682,0.064040445,-0.05975682,0.02697632,0.015067317,-0.029556656,-0.103185624,0.03402441,-0.14904973,0.033990335,0.063977115,-0.0115160765,-0.039179638,0.08291574,0.0056661763,-0.066638306,0.06257426,0.01548909,-0.004835674,-0.03797453,-0.07793079,0.009840337,-0.110437766,0.027334629,-0.035558283,-0.041276347,0.0156503,-0.02078601,-0.039252013,0.06345035,0.052849796,0.03399184,-0.05791256,0.103463836,-0.0027413997,0.014722205,0.120873064,-0.007890181,0.0043247333,-0.06221445,-0.10103074,0.018428113,0.0019216218,-0.038635027,-0.021028167,-0.04030553,-0.0010288394,-0.044089563,0.14964604,-0.0335624 +2.6.1.106,"A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction.",384,1.0,-0.08541274,-0.03342514,-0.056863815,-0.117540926,0.004650738,-0.044915836,0.035328995,0.086983554,0.06612284,0.09938041,0.021469412,0.013471355,-0.019427327,0.06717325,-0.018972596,0.028950619,-0.06061369,0.031147776,0.045381837,-0.01726872,0.059574835,0.059933666,0.040195983,0.030514946,0.047017746,0.088189684,0.09421787,0.064933226,-0.007867035,-0.08294022,0.0023458824,-0.041814346,0.038148534,-0.03452527,0.065414764,0.07184051,-0.09001579,0.008168284,0.075934045,-0.029324867,0.05590436,-0.013947815,0.02537301,0.019723885,-0.028810067,-0.014527885,-0.056157388,0.105498664,0.04914088,-0.003570814,-0.016566046,0.016371692,-0.021788066,0.04506524,0.05743001,0.018995037,0.0455023,0.009749962,-0.06454532,-0.013681835,0.060446296,0.0048271865,0.023425294,-0.003478835,-0.0058545363,-0.027618295,0.0141156195,-0.056001138,0.030979848,-0.024318153,-0.071595,-0.066653915,0.07458585,0.04237364,0.007823715,-0.015409423,-0.030216413,-0.015749464,-0.057201613,-0.06234456,0.06660822,0.019077856,0.032751635,0.112754665,0.025444152,-0.025490835,0.07664287,0.000403297,0.10296538,0.019620795,-0.004708099,0.004673158,-0.029543063,0.021383127,-0.11065221,-0.019732742,0.0046110987,0.0070896796,0.022697512,-0.008323402,-0.036913052,0.027000915,-0.041468125,-0.06971368,-0.07425614,-0.005875922,-0.011949589,-0.0068342304,0.010751907,-0.030063929,-0.029273428,0.040240012,0.017145963,0.083493076,-0.0588896,0.0066110766,0.078223854,-0.06296957,-0.06290193,-0.042471886,-0.020674704,-0.045165833,-0.018805785,0.06985135,-0.031138008,-0.009566668,-0.101290315,7.184443e-34,0.078822985,0.0345219,-0.05265532,0.005073472,0.043029893,-0.000191888,-0.06244851,-0.014936212,-0.07693229,-0.031364918,-0.09514563,-0.079266705,0.046511214,0.068995625,-0.08853477,-0.030748054,-0.001972917,0.09501361,0.056731116,-0.0031752973,0.034783784,0.10287122,-0.071585126,0.02233353,0.023457497,0.15613316,-0.0667942,0.06368025,0.10508723,-0.005440189,-0.039355207,-0.0952083,-0.053805444,0.008886956,0.069972895,-0.055941265,-0.10550659,-0.029321969,0.057479568,0.016811391,-0.034769993,-0.041220203,-0.053107884,-0.020480793,-0.022216877,-0.026085412,-0.00029175033,0.027498255,0.011937598,0.04611873,0.07806241,-0.0930621,0.057119064,-0.049374808,-0.08158073,-0.008985964,-0.093648754,-0.007140494,0.0457216,0.042766526,0.038804147,0.0011340103,-0.050048158,-0.022888942,0.037595857,-0.033985183,0.0018922517,-0.03033802,0.044609707,0.022210913,-0.04598277,-0.023377856,0.04734392,0.024806276,0.01847302,0.017429754,-0.02235239,0.025978407,0.033600084,0.05190641,-0.06068014,-0.058254033,-0.06421114,-0.097673364,-0.03724988,0.040061865,-0.0202009,-0.09746614,-0.039926104,0.02884555,-0.054657362,-0.12416031,-0.07855129,0.026131446,0.034717645,-3.5882138e-33,0.06759225,-0.06401639,0.10202289,-0.05863717,-0.040510025,0.033325333,0.02160765,-0.019728983,0.07736452,0.008370392,0.055142466,-0.04383108,-0.05036345,-0.03362166,-0.014508479,0.020586785,-0.005195939,0.050254736,-0.022347668,-0.00064106967,0.022628829,0.073359355,-0.0095280595,0.011517204,0.049033776,0.059696015,0.028477727,0.06856578,0.0059800283,0.043489106,-0.016818147,0.0035662893,-0.04909135,-0.035156284,-0.06854864,0.066301644,-0.07157683,-0.046482112,-0.025028758,-0.020171696,0.010744504,0.017135076,0.039597064,0.023354195,0.032912247,0.03318401,-0.05395679,0.04181696,0.0074705025,-0.03826229,0.06138475,0.06150048,0.05830268,0.00062741246,-0.030914867,0.012408586,0.03892956,0.048282072,-0.012870931,0.010814019,-0.0013273404,-0.10744295,0.022271026,0.0721273,-0.031656493,0.04974091,-0.011013046,0.022211015,0.09125894,-0.0055786604,0.066111304,0.04480873,-0.0061294027,0.026003746,-0.07365008,-0.024566166,-0.06258777,-0.018375922,0.048095837,-0.0041925022,-0.037228126,0.006921721,-0.016024053,-0.020416034,-0.08131949,-0.014283366,0.056771055,0.019398669,-0.024904337,0.011054819,-0.018637959,0.025130585,-0.02662629,0.09012933,0.059625935,-3.97648e-08,0.083472416,-0.03833424,0.035054162,-0.031000724,0.038137555,-0.020040838,-0.06633587,0.02299659,0.0582709,-0.03657516,0.009238997,0.07788876,-0.010496976,-0.01967987,0.035301346,0.03898455,-0.06103553,-0.019752756,-0.029507596,-0.03490837,-0.023356777,-0.02146328,-0.11526566,0.057689782,0.06655515,-0.018484332,0.0042892112,-0.027133599,-0.02382417,-0.007353077,0.06561655,0.004664264,-0.04727824,-0.04145108,0.0123222135,0.019661836,-0.087274194,-0.1076115,0.027459206,-0.025613682,0.02349922,-0.010843662,-0.023291703,0.015938658,-0.08235277,0.07409411,-0.042343035,-0.0039615175,-0.062774055,-0.0037071914,0.06144913,0.028133681,-0.0914432,-0.075126536,-0.15437165,0.04392732,-0.010265965,-0.0651356,-0.03592117,-0.06827305,-0.02405067,-0.010605641,0.15070914,-0.06811951 +2.6.1.107,Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.,384,1.0,-0.033008035,-0.0023572808,-0.15355413,-0.09103954,-0.0057491027,0.039640278,-0.006405626,0.04882405,0.046764273,0.018328767,0.03146979,0.01593426,0.0066676927,0.066520154,-0.03592474,-0.048142795,-0.035933387,-0.0061526997,0.02721829,-0.041914992,0.08232396,0.14328226,0.053116582,-0.0046370053,0.008294431,0.029163588,-0.008132109,-0.002885199,0.0074194223,-0.05578976,0.029242622,-0.020263024,0.011984488,-0.10679424,0.11471921,0.10040093,-0.08772592,0.004358774,0.13354164,0.009595858,-0.0047573913,-0.0682739,-0.010755784,0.03174886,-0.065474205,0.06298713,0.046141587,0.08128336,0.041602246,-0.001098631,-0.07906593,0.0023338473,-0.041689537,0.0071857995,0.05083726,0.03912222,0.0026913856,-0.0013130936,0.016627202,-0.04716653,0.017705422,-0.035506744,0.08659993,0.018652266,-0.067143306,-0.037151076,0.039476592,-0.09099741,0.07153097,-3.1825646e-05,-0.035625264,-0.02943126,0.05521012,0.031249989,-0.034313217,0.060889058,-0.00952436,-0.08096639,-0.0020397082,0.0036535496,0.06327639,-0.018044036,0.051258385,0.10969493,0.027640834,-0.012297652,0.004215045,0.0063231443,0.0132077895,-0.021714794,0.040863816,-0.013706523,-0.0039069806,-0.06798455,0.0015069272,-0.021517225,-0.05952295,-0.017298235,-0.022744427,-0.01842864,-0.03319483,-0.009229016,0.041444547,0.017985657,-0.06485172,-0.010387257,-0.03917854,-0.010142294,0.00793172,0.00078097463,-0.044509996,0.09043041,-0.05671434,-0.0835887,-0.009211782,0.00488704,0.13818936,-0.041395523,-0.090346865,-0.014863852,0.00063859724,-0.017436238,0.009535154,-0.00040279274,-0.015190127,-0.002419085,-0.08392823,5.7553085e-33,0.008454895,0.08682707,0.0537426,-0.04790038,0.04426809,0.0042482736,-0.045406032,-0.08708022,-0.041769512,-0.03974384,-0.035450876,-0.05391788,-0.0068651047,0.061928894,-0.055388168,0.024068942,-0.047681626,0.068735056,0.0334743,-0.045573175,0.048563376,0.05414553,0.0066701598,0.03670903,0.006574637,0.09727814,-0.004017587,0.012153916,0.08893663,-0.025991611,0.07490363,-0.067211956,-0.0856451,-0.052391104,0.071696766,-0.07384891,-0.11444012,-0.09456823,0.06169279,0.05940118,-0.0243693,0.01600223,0.010581536,-0.002855636,0.06420291,-0.018523786,-0.033938963,0.07551063,0.023259427,0.051960476,0.057957947,-0.045427196,0.02626707,-0.025192492,-0.06749877,-0.030110836,-0.020691302,0.002811983,0.052998416,0.047389165,0.027612222,0.021422625,0.008900989,-0.015136198,0.095576465,-0.028567836,-0.023333268,-0.02707342,-0.010000469,-0.0019034678,-0.0068700444,-0.046391007,0.018487664,0.038194876,0.003798243,-0.016953269,-0.039583873,0.0011029387,0.02487388,-0.008449343,-0.035130475,-0.03652565,0.00943444,-0.04694242,-0.066982344,-0.0065412545,-0.053087298,-0.08720354,0.015845584,0.04840634,-0.047964882,-0.06524799,-0.10524406,0.02610369,-0.037062667,-7.210227e-33,0.087136894,-0.018000612,0.09748178,-0.01777839,-0.033989016,0.057518177,0.023495696,-0.039040104,0.047248762,-0.013152671,0.036537442,-0.018701782,0.02760525,-0.0637313,0.0010129792,-0.0033461433,0.012957066,0.10452495,-0.020748064,0.056267425,0.049055636,0.04775528,0.000814207,0.0013871432,0.03897362,0.027383097,-0.021710034,0.012494357,-0.014776671,0.039253123,-0.007013681,0.018877415,-0.080594696,-0.0942221,-0.06529179,0.006757085,-0.09231398,0.02126691,-0.0032231417,-0.067205936,0.058914836,0.050668668,0.06043608,0.010874765,-0.015315515,0.036885433,-0.011481034,0.05821044,0.008726094,-0.024580503,-0.020150652,0.038508106,-0.018213259,-0.023353998,0.05695204,0.019115442,-0.0204341,0.003282581,0.03040959,-0.04305325,-0.016030803,-0.051946267,-0.00012576216,0.007068245,0.06174203,0.09259527,0.040772658,0.0069737216,0.09041624,-0.0024858022,0.028975934,0.03808557,0.054849226,0.034543768,-0.015908929,0.08853717,-0.097125635,-0.027519096,0.050880868,0.022745218,0.028548324,-0.03482151,-0.016652415,-0.013959743,0.04146166,-0.05600119,0.07192717,-0.0062855855,0.00368663,0.017259862,-0.024328789,0.012345833,-0.009470028,0.04811815,0.049793884,-3.5097607e-08,0.08700444,-0.021984419,0.06313454,-0.08080488,0.024071874,-0.055917397,0.01736096,-0.007319195,0.02933661,-0.010368539,-0.01656209,-0.0075166924,0.04813529,-0.054574266,0.013944344,0.033693857,-0.07653602,0.03994574,-0.021051995,-0.07167314,-0.114432946,-0.00633524,-0.069718234,0.06563458,0.06723194,0.011889812,0.059269153,-0.034868855,-0.0014317514,0.021104764,0.07464584,-0.0067344825,-0.057681162,-0.05947285,-0.06765562,-0.008554355,-0.10259846,-0.0067536808,0.009287497,-0.032025352,-0.059023302,0.003471298,0.005414228,0.018676711,-0.10302461,0.06695394,-0.10524658,0.018173316,-0.13417545,-0.0070719174,0.0429549,-0.008883348,-0.040586058,-0.036431994,-0.1811301,0.050247017,0.050430074,-0.09023045,-0.049828824,-0.094778515,-0.04687541,-0.033827983,0.16579042,-0.044064894 +2.6.99.4,"The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg [3]. ",384,0.99999994,-0.10390316,-0.056419604,-0.11983688,-0.038314633,-0.021178562,-0.032473788,-0.043961585,0.021785203,0.010826548,0.0374555,0.04982082,-0.043973044,-0.07161725,-0.03534051,-0.089181885,0.046909835,-0.07402095,-0.032396995,0.07966157,-0.033197004,-0.023355514,0.096240796,-0.0059775305,-0.019122217,0.044863354,-0.0012128227,0.026385857,-0.07591457,0.043864593,-0.06696818,-0.054297827,-0.016747616,0.064157754,-0.049883667,0.029524587,0.06393415,-0.16203402,0.00013646139,0.13437705,0.010651193,0.004029406,0.010551271,0.00817097,-0.063507736,-0.050720263,-0.07064013,-0.00407022,0.06645628,0.031772677,0.08129549,-0.0031100796,-0.04436562,-0.07326584,0.024526274,0.016108626,0.059946842,-0.089548334,-0.020188186,0.0005627466,0.07029717,0.13734919,0.066990614,0.0020007242,-0.050585162,0.056986175,-0.04145829,0.01815954,0.05156488,0.09328707,-0.012773152,-0.0019378928,0.02050829,0.012149522,0.023756102,-0.055064905,0.026328033,0.027043933,-0.024061292,-0.0017054552,-0.004834293,-0.032155827,0.003004156,0.06913104,0.08107303,0.046780564,-0.01538639,-0.013076813,0.06462977,0.03388602,0.034496322,0.08830969,0.0146969855,-0.046528336,-0.04420842,-0.034969237,0.050353143,-0.0123577155,0.098399915,-0.0075113853,-0.024459397,0.004951891,-0.012503546,-0.009454056,-0.09607199,-0.0408441,0.036382966,0.013331232,-0.021550693,0.040633205,0.017541416,-0.032733433,0.05060888,0.008670951,-0.007134677,-0.046216786,0.020777222,0.0071113645,-0.050507262,0.028783143,0.00437728,-0.03706318,0.01656114,0.033825904,0.01538234,0.0021025878,0.024625896,-0.049251083,1.904231e-33,-0.012386759,-0.010439267,0.010650905,-0.019782893,0.07669886,-0.0077801454,-0.010568728,0.007225481,-0.09514312,-0.029239967,-0.07780428,-0.06084776,0.018689007,-0.020099165,0.02556318,-0.031369787,-0.029209653,-0.017900938,0.029593486,-0.046049893,0.00059932994,0.07621341,-0.05998,0.0073496527,-0.020161081,0.072674684,-0.005150373,0.043013938,0.0507838,-0.012317165,0.0049139587,-0.017666759,-0.027517427,0.007212758,0.10459658,-0.06286241,-0.054477647,-0.013712494,-0.09506864,0.027202845,0.054547776,0.011786004,-0.03596802,-0.019231297,-0.037841756,-0.041118316,-0.020701084,0.06453603,0.019090086,0.008875009,0.042048413,-0.038177088,-0.010046213,-0.022029381,-0.016025124,0.0030349784,-0.0019595495,-0.0054312972,0.12715827,0.052682962,0.026627034,-0.03177327,-0.005021816,0.034435205,-0.039764177,-0.032479174,-0.06320426,-0.0357638,-0.016289955,0.0053250273,-0.026017739,-0.052582394,0.015621336,-0.012299262,0.042308353,-0.03289393,-0.09323593,-0.006943766,-0.032181613,-0.024736369,0.05126251,-0.029633624,0.030623754,-0.046070702,-0.052875377,0.013340353,-0.01827495,-0.04907539,0.037783924,0.105806954,0.023039492,-0.030525634,-0.16054058,-0.0058525,0.05575986,-3.4407715e-33,0.104589224,-0.088294655,0.064021826,-0.045766376,-0.13269556,0.05878755,0.012832861,-0.11505736,-0.010978166,-0.040510733,0.11179798,0.0054674246,-0.03251002,-0.021801846,0.050425496,-0.031535726,0.04888156,0.019593993,-0.017829329,-0.08186818,0.016028157,-0.016369317,-0.033981517,0.016862612,-0.01940892,-0.018012257,0.014497446,0.053136423,-0.0016508217,0.1040866,-0.028863918,-0.02366507,0.020808393,0.07133249,-0.07246765,0.024732599,0.032985087,-0.018765114,0.03532734,-0.032009702,0.060856503,-0.027453987,0.02146981,0.075501114,-0.0290089,-0.002697023,-0.049757954,-0.02754336,-0.08192172,-0.0635007,0.13279188,0.022205766,0.06293257,-0.0040038177,0.04923421,0.06853605,-0.04375854,-0.053083546,0.081101306,-0.0306568,-0.01433837,-0.06457233,-0.012387912,-0.03857182,0.10414166,0.030841006,-0.09768838,0.13396874,0.0332113,-0.030103479,-0.028897204,0.020595605,-0.056800574,-0.019335084,-0.03559232,-0.03231618,0.024139015,-0.025958758,0.037563946,-0.085307494,-0.040145665,-0.046815917,0.017375393,-0.058011997,-0.027925227,-0.023202803,0.07989138,0.13392076,-0.033273637,0.09301126,0.021837551,0.030472508,-0.022500573,0.025582263,0.072433874,-3.8469903e-08,-0.04793169,-0.10054835,-0.02754008,-0.018246979,0.04917831,0.021518178,-0.00930708,0.0715826,0.019074444,0.042791385,-0.005227509,0.02788464,-0.0028197265,0.0646262,0.028722668,0.040387534,-0.07256155,0.0034411026,-0.014390633,-0.016691616,-0.092718124,0.05463401,-0.11380896,-0.0028789865,-8.380604e-05,-0.009243467,0.029874945,0.032192316,0.007465099,0.028302263,-0.028602354,-0.000207358,-0.016458308,-0.08176588,-0.011395129,0.07302699,0.055931944,-0.09771765,-0.047643412,-0.023712862,0.018116217,0.07656717,-0.077793956,-0.008058952,-0.058285777,-0.006104131,-0.005774376,0.094055206,-0.04550581,0.03055196,0.036280617,0.031222202,0.031309422,-0.006994483,-0.039785065,0.027723245,0.00092294364,-0.056689013,-0.084313214,0.06931809,0.018407343,-0.031194152,0.1441479,0.012442774 +2.7.1.181,"The enzyme is involved in the biosynthesis of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a. O-Polysaccharide structures vary extensively because of differences in the number and type of sugars in the repeat unit. The dual kinase/methylase WbdD also catalyses the methylation of 3-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.1.1.294, 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase).",384,0.99999994,-0.029090872,-0.04080807,-0.13305297,-0.047604892,0.0009978589,-0.0025399623,-0.025461394,-0.0036943546,0.116830245,0.003770182,0.02696043,-0.011550575,-0.084801294,0.0042546517,-0.024824532,0.01752593,-0.09785494,0.08287571,-0.040400192,-0.009948416,0.13019791,-0.053615063,-0.032770578,-0.018029513,-0.061556205,0.020342678,0.049032304,0.008795778,-0.00027198787,-0.10803887,-0.016178977,-0.032985296,0.111322634,-0.03889308,0.08408143,0.0806059,-0.024292385,-0.049004886,0.020452155,0.022323217,0.058100667,0.023245143,0.03366547,0.011624044,-0.050208334,0.015485249,-0.109323904,0.017929861,0.05181914,-0.03742575,0.013927883,-0.08602262,-0.040537618,0.07977516,0.06072738,0.017782357,-0.031260587,-0.017328057,0.014975389,0.0112187965,0.0124999145,0.024424063,0.049313154,0.023486877,0.005725425,-0.026000021,0.039840873,-0.05594218,-0.012257817,-0.023278935,-0.06498852,-0.021191576,0.005087692,0.014209895,0.024965676,0.0013952663,-0.0145843625,0.011742211,0.0064882003,-0.040249065,0.07207945,0.026804252,-0.047784306,0.06239573,-0.04770729,0.026115013,-0.06479333,0.026933497,0.12240343,0.08534078,-0.04456303,-0.036627226,0.00820937,-0.07799945,-0.05404273,0.013516528,0.02451215,0.10186166,-0.002053208,0.016362544,-0.015268405,-0.012151561,-0.00038954706,-0.07586133,-0.023519749,-0.016221369,0.017180162,0.05859019,0.0016690869,0.031823833,-0.047447767,0.040106658,0.0377421,0.0071935104,-0.08772598,0.013918094,0.0486815,-0.084220245,-0.009407045,-0.0150003405,-0.02155544,-0.05862446,0.08876399,0.052575894,0.0043127923,0.030295508,-0.066927135,-4.1350405e-33,0.05569993,0.043443706,0.03189814,-0.04291805,0.033982642,-0.048054572,0.027223656,-0.06592461,-0.038910884,-0.028509757,-0.106367774,-0.07461152,-0.0044235648,0.05356618,0.03938326,0.023193955,0.036470313,-0.038537372,-0.05806431,0.010618604,0.008992827,0.058180854,-0.036604077,-0.038409065,0.068371035,0.018214887,-0.027293911,-0.017123502,0.07357337,-0.02006728,0.04130809,-0.022050273,-0.10290098,0.095041074,0.09741822,-0.029351821,-0.1120562,-0.03411724,0.004997141,0.07184792,-0.016895073,0.032656033,-0.013532069,-0.009781248,0.028258406,-0.057454083,-0.008110569,0.07526693,0.0906898,0.04606175,0.008718159,0.020752333,0.057946406,-0.014225079,-0.04843341,-0.0645372,-0.04874531,-0.025435334,0.0048825126,0.09939298,-0.0047049643,0.043831997,-0.0065108472,0.049946643,0.009794426,-0.000433956,-0.09203517,-0.0007121511,0.0048638615,0.04321081,-0.026862472,-0.11828911,0.03703412,-0.013287467,0.060415167,-0.0060242177,-0.028745385,0.029033627,0.0005696283,0.018382438,0.05845952,0.02857968,0.015034903,-0.029355329,-0.15116346,0.09284273,0.027043963,-0.061245084,-0.022192357,0.112538524,0.00045371734,-0.07880158,-0.034383316,0.054471467,0.05214905,1.1587555e-33,0.038874008,-0.0911358,0.10871712,-0.11932159,-0.048661307,0.040835153,-0.016281636,-0.010365926,0.023017589,-0.03952037,0.026156422,0.08755612,0.037986204,0.018882435,0.006569978,0.0153079685,-0.015474134,0.15516357,0.0062071285,0.004923056,0.037179302,0.080710776,-0.031013237,-0.0036212984,0.06871171,0.009801329,0.050191555,0.11410076,0.019612018,0.022192655,-0.01551868,0.0036142208,-0.050043106,0.038056783,-0.04229065,-0.0063540484,-0.045716524,-0.0030233727,0.026242707,0.065551326,-0.075169474,0.051922623,0.011278068,-0.028548965,0.03829758,0.11296601,-0.06425688,0.024286013,0.014010898,-0.021356767,0.008635359,-0.010359188,-0.034026094,0.06924227,0.034031298,-8.5312175e-05,0.04623733,0.04186485,-0.03506547,-0.07336714,-0.04400598,-0.048794188,0.043454472,0.0011631022,0.039829858,0.06354154,0.037439905,-0.03960467,0.028866967,-0.015452965,-0.014724573,-0.037864976,-0.04668112,-0.017696807,0.021342337,-0.00538392,-0.099469855,-0.01723761,-0.03455131,-0.033995368,-0.04083944,-0.035830617,-0.008337926,0.0028660404,-0.03807595,-0.013028841,0.10895514,0.08962182,-0.048572425,0.06066485,-0.014743388,0.004755509,-0.0661523,0.11564454,0.10910478,-5.6831098e-08,0.028312778,-0.108577825,-0.027070211,-0.07294111,-0.0067665824,0.004974176,-0.019716864,-0.04912942,0.04886506,0.043028384,0.0043463386,0.10851319,0.011443676,-0.0038646634,0.033269867,-0.009851022,-0.019309375,-0.0065837186,0.0058224034,0.008886366,-0.0155512225,-0.025180338,-0.08035205,0.018895172,0.034373973,-0.085703604,0.0024803556,0.04238304,-0.050117582,0.012127895,0.043778826,0.028396849,-0.003506706,-0.0898147,-0.00069667364,0.008901796,-0.064001195,-0.06691536,0.02084321,0.04207541,0.070058934,0.0029704568,-0.0073401686,0.039414275,0.027930297,0.0005523394,-0.0093216915,0.06507487,-0.055432077,-0.013564166,0.04903909,-0.006920917,-0.019463694,-0.08821008,-0.089626655,-0.100424364,-0.030556682,-0.034096967,-0.012648901,-0.025497837,0.029784435,-0.054275718,0.13798729,-0.04959646 +2.7.1.182,The enzyme is found in plants and photosynthetic algae [2] and is involved in phytol salvage [1]. It can use UTP as an alternative phosphate donor with lower activity [2].,384,1.0,-0.10392074,0.010900077,-0.02267979,-0.0316599,0.039849777,0.07053132,-0.032929216,-0.0061989157,0.0072680493,-0.0007496992,0.048849847,0.024270952,-0.052253723,0.06419058,-0.038492117,0.08191812,-0.0028853656,0.061694182,-0.019305037,-0.017515209,0.048870485,0.024013966,-0.029650243,-0.03146891,0.080712706,-0.021426896,0.018734893,0.010287204,0.006693723,-0.08559734,-0.0640489,0.015747927,0.019775508,-0.08507337,0.0061933845,0.12713885,-0.066341415,-0.12444037,-0.005821823,-0.026407126,0.047489204,-0.043170895,-0.037476197,0.027964847,-0.058964558,-0.03242098,-0.009396791,0.020268248,0.037464965,-0.07006834,-0.047016747,-0.019153705,0.017595744,-0.028602773,0.0045762253,0.017137486,-0.008475013,0.028288642,-0.03852923,-0.00018302078,0.0691687,0.006268459,0.016441083,-0.024774773,0.04396245,-0.020139726,-0.03832307,-0.07239779,0.049537387,-0.10796701,-0.045394186,-0.11475134,0.019656472,0.042375393,-0.022749506,0.0017082801,0.021366455,0.022952782,0.007710827,0.039277907,0.06098425,0.053680446,0.022502998,0.058268096,0.099364065,0.016946102,-0.016442865,0.06881668,0.009755213,-0.032010347,0.043905813,-0.0017624251,-0.0158201,-0.005303064,-0.06281363,0.088958256,-0.07020005,-0.008349259,-0.025767725,-0.04826104,0.031840295,0.043636117,0.007981132,-0.1406943,-0.01928431,0.01869348,-0.03733668,0.047672436,0.004794881,-0.032516148,-0.020585308,0.036090244,-0.016467031,0.036349524,0.059977144,0.10056358,-0.012086493,-0.08017106,-0.06477017,-0.015398886,-0.014383289,-0.100564994,0.01500178,0.049728572,-0.05041715,0.042199746,-0.12733696,-1.6802518e-33,0.053459015,0.015493018,-0.024074184,-0.051432412,0.032527912,-0.017971288,-0.00074746367,-0.040262293,-0.043517493,-0.17203951,-0.08178596,-0.027851343,0.040106136,0.012226138,-0.094726995,-0.05315659,-0.020371117,-0.013816591,0.07794178,0.02934949,0.04632393,0.055914387,-0.06412051,0.027968405,-0.009203697,0.06267125,-0.010379892,-0.017564539,0.07835162,-0.017912978,0.07259607,-0.06452701,-0.10857853,0.022912348,-0.03321353,-0.0058788517,-0.06687171,-0.07428616,-0.06196927,0.054378908,-0.025303952,0.08785798,0.031074507,0.08238129,0.094609246,-0.050791673,-0.06867049,0.062003408,0.031218655,0.06831639,0.019648224,0.011166515,0.04229716,-0.0313847,-0.08900274,0.0054790145,0.012474016,0.006078066,0.0009824255,0.016387636,-0.009373576,0.0056110877,0.009451704,0.061864447,0.020188862,0.057668496,-0.034316998,-0.024312459,0.0033778918,0.0926499,-0.051842414,-0.035733543,0.017974311,0.021618363,0.02313424,-0.10208213,0.026414713,0.01607941,0.0017973917,0.05175754,0.032118123,-0.07840249,0.006640201,-0.013401561,-0.048593,-0.03960233,-0.03383126,-0.044233415,0.03820963,0.0011905372,0.10700625,-0.016855448,-0.0669785,0.019390518,-0.007765978,3.3453164e-34,0.16810443,-0.091263086,0.057404477,5.3888572e-05,-0.032609098,-0.009501331,0.031865,-0.04397841,0.08082541,0.03806233,0.0739976,-0.019461641,0.07288451,-0.024397312,0.019072529,0.04270143,0.041738424,0.066676244,-0.03056222,0.024697406,-0.059148297,0.10738729,0.07892301,0.013406809,0.027373409,-0.012167234,-0.0075706975,-0.035349473,0.023110619,-0.021494877,-0.01207343,-0.015111189,-0.07894265,-0.06316176,-0.058061805,-0.0088803815,-0.04011656,-0.053701203,-0.014284038,0.052013863,0.060805503,0.007525434,0.00515733,0.052635655,-0.029147506,0.0688223,-0.050643716,0.06835216,-0.04828208,-0.059545577,0.05417519,0.069392554,-0.0012932882,0.04978824,0.014194497,0.05377199,0.052040447,0.039121486,-0.048389744,0.018003153,-0.016842779,-0.032767132,0.0504436,0.01518055,0.00015321339,0.12826705,0.0010432015,0.06271613,-0.062874116,0.037911966,0.028984616,0.015037804,0.030917248,0.061364405,-0.03816895,0.0526279,-0.088046186,0.010797165,-0.01764427,-0.028790547,0.021905333,-0.027068786,-0.04080894,-0.07868794,0.027293276,-0.08530674,0.015666895,0.08570834,0.016337913,-0.011626857,-0.03401925,-0.046324626,-0.058702484,0.046177708,0.13082479,-2.882018e-08,-0.015386145,-0.025130834,-0.009631748,-0.06353747,0.02017022,-0.022607105,0.020240538,0.04522947,0.034884635,0.03544099,-0.058148798,0.07718419,-0.035587516,-0.017933773,0.0678102,0.00842339,0.076185405,0.024786854,-0.00044072542,-0.0026948282,-0.037859235,-0.019787308,-0.078290574,0.06179681,0.007610027,0.040022295,0.0414602,0.043665342,0.019900654,-0.078805506,0.033552386,0.015021732,0.022795226,-0.01001679,-0.039868914,0.08119058,-0.016195413,-0.047891293,-0.06112698,0.054882985,-0.04420306,-0.07781322,0.0042519555,-0.02951286,-0.022795185,0.03701032,0.032011725,-0.010676254,-0.0383689,-0.015104607,0.0706994,-0.09133751,-0.030120458,-0.101709716,-0.094950914,0.04261825,0.04518621,-0.08168611,-0.013379573,-0.037789434,-0.0019301749,0.032618545,0.14266679,-0.033038292 +2.8.3.20,"The enzyme, purified from the bacterium Clostridium tetanomorphum, can also accept itaconate as acceptor, with lower efficiency.",384,0.99999994,-0.03771958,0.02978427,-0.110641345,0.009390738,0.056598447,-0.030728327,-0.021589007,-0.000119179786,0.025370356,0.022348456,0.050337177,-0.058358736,-0.044469062,0.09194887,-0.021485517,-0.005533805,0.008867239,-0.022283483,0.08524304,-0.0016604859,0.017746057,0.080180936,-0.028269194,-0.035855122,0.011560503,0.020210773,-0.003602842,-0.041044764,-0.025887938,-0.07758657,-0.07426809,-0.08036779,0.036529955,-0.007915768,-0.02434883,0.09744247,-0.087982096,0.019922238,0.09237194,-0.04156534,0.018499024,-0.0010564151,0.010952581,-0.050759554,-0.09680155,-0.0018093162,-0.020175813,-0.0016198878,-0.021905327,-0.036689803,-0.04221353,-0.006543066,0.022271184,0.0028817179,-0.023796441,0.04025427,-0.010819112,-0.008662584,-0.067358844,-0.043986317,0.018590888,-0.056423698,0.0062813433,0.038376436,0.030987762,-0.10951175,0.0574445,-0.048621885,-0.049047478,-0.045836534,-0.014152986,-0.025824763,0.043750137,-0.031179328,0.07576848,0.04868361,0.008763136,-0.0085029965,0.031176982,0.054631244,-0.022440013,-0.023526236,-0.04233868,0.031746216,0.011623761,0.0293076,-0.013410281,0.023669228,0.02723899,0.0873336,0.11505574,0.040143315,0.027810609,-0.07216523,-0.013707609,-0.009444304,0.050791584,-0.019487537,0.0174125,-0.07483295,-0.026434591,0.025581937,-0.11908099,-0.09649504,-0.08362285,-0.021148723,0.050805185,-0.03551659,0.09439671,-0.019616388,-0.046971727,-0.00014701128,0.08947971,0.07500302,-0.02072366,0.07783598,-0.0023219706,-0.09635995,0.018923135,-0.0077028847,-0.0715187,-0.020898862,0.04984016,0.056816515,-0.05317184,0.039363254,-0.009691109,9.534495e-34,0.011416932,0.0675326,-0.014356923,-0.08005148,0.007363498,0.028075088,-0.051344924,0.027564459,-0.04256354,-0.06103066,-0.14322226,-0.09585696,0.018263474,0.06887634,-0.005609135,-0.006574,-0.015435727,0.024133055,0.043953724,-0.030610587,0.053672686,0.05456549,-0.05733966,-0.0034647007,0.045101386,0.07206557,0.018704467,0.029779423,0.0019680986,-0.0028106913,0.068403006,-0.06505391,-0.07177721,0.015275512,0.10181642,0.0037994466,0.015401795,0.0415832,-0.05946607,-0.015256278,0.0065589435,0.04719934,-0.05566942,0.050247908,0.04959687,-0.018296836,-0.0012392469,0.04365045,-0.046514682,0.03365122,0.017542383,-0.0047425297,0.011279465,-0.10590405,-0.031583417,0.059228472,0.038955025,0.05828729,0.07211642,-0.0047081583,-0.014261912,0.08507551,-0.0350665,0.0075881286,-0.008342283,0.023998844,-0.03627362,-0.08149535,0.009758191,0.03673377,-0.057778545,-0.011921215,-0.08937288,0.029996643,0.014892342,-0.06295777,-0.031061703,-0.010740775,0.0489696,-0.06423761,0.004364357,-0.073915355,-0.0015704894,0.004129603,-0.018836433,-0.04232237,-0.055565033,-0.0125835445,0.058306873,0.031003831,0.079701945,-0.05152065,-0.06104458,0.013929372,0.07732049,-3.0934897e-33,0.13558452,-0.12760705,0.04166226,-0.00050247257,-0.014125069,0.12163593,-0.018558936,-0.012954594,0.052732065,-0.08003374,0.036664747,0.03168461,0.075998195,-0.017808398,0.027426336,0.0107915215,-0.0013953632,0.056060158,-0.05363905,-0.016001016,-0.038416117,0.058978796,0.02222508,-0.03385958,-0.0029223545,0.076214656,-0.046879526,0.08609341,0.07044464,0.016742347,0.0145699885,0.0090560205,-0.024323719,-0.07164444,-0.019046303,0.021101538,-0.099181235,-0.007862647,0.04248713,0.026334906,0.0077009886,-0.012194842,-0.02876585,0.054152366,-0.0024404782,0.02893578,-0.02048996,-0.012145514,0.04223352,0.004766144,0.0691066,0.03190048,0.023541477,-0.016604856,0.12298734,-0.021078926,0.07330001,-0.08748027,-0.04590678,-0.07832669,-0.055453643,-0.066443294,0.083314985,0.0015170032,0.047236,0.014319832,-0.016586147,0.07608205,0.051797483,-0.07574314,0.080094844,-0.0587066,-0.0017908607,0.0157822,0.010811297,0.061586216,-0.03650768,-0.0027609135,0.058415134,0.00945464,-0.06478369,0.0670888,0.041798603,-0.084603,0.06665991,-0.07328217,0.021690927,-0.03004218,-0.025863165,0.04514533,-0.03683909,-0.027096448,0.029419992,0.023138246,0.09414345,-3.222048e-08,0.0111572975,-0.06324283,0.10242326,-0.01866807,-0.011781212,0.020310638,0.022522362,-0.008219067,0.0059288833,-0.068115994,-0.016631596,0.040377203,0.052571088,0.036653567,0.0961764,-0.011337906,-0.056580886,-0.0033284766,-0.04952717,0.0028054123,-0.12926444,-0.05292412,-0.07981356,-0.07805134,0.05844656,0.028213084,-0.007572584,-0.027044587,0.004608389,-0.04553201,-0.059263997,0.002583329,-0.025189498,0.0037891592,-0.10671207,0.05231316,0.008389747,-0.05257895,-0.04335266,0.015470606,0.0843038,-0.026301732,-0.103384346,-0.014140545,-0.07429649,0.030867344,0.025575193,-0.01220279,-0.09710342,0.022130854,-0.016852362,-0.03528339,0.03525039,0.022659805,-0.053435743,-0.006636865,0.019092768,-0.043627936,-0.059184115,-0.06418572,0.046985146,0.019754661,0.18581395,0.010223773 +2.8.3.21,The enzyme is found in gammaproteobacteria such as Proteus sp. and Escherichia coli. It has similar activity with both substrates.,384,1.0,-0.07424014,-0.09548211,-0.13495216,-0.021175807,0.034817584,0.067874715,0.0060225492,0.09921386,0.030820213,0.022416277,0.08829754,0.0035272622,-0.010747477,0.09021603,-0.017524216,0.023600295,0.023033088,-0.06381938,0.05103304,-0.060897615,0.089100204,-0.00020489823,0.0017109179,-0.01832395,-0.040163796,-0.018745318,0.102693215,-0.041258205,-0.002510928,-0.017608015,-0.045535788,-0.06319686,0.053444974,-0.0030234207,0.07458358,0.07633347,-0.04722499,-0.085463956,0.06821538,-0.045884505,0.019459046,0.03611467,-0.050075132,-0.052577354,-0.014640336,2.9128458e-05,0.020948747,-0.018334873,0.05338616,-0.027764393,-0.020923533,-0.07191518,-0.00064742996,0.04236072,0.0035196408,0.06793966,0.0096290745,-0.086623855,-0.026764339,0.06674154,0.027750384,0.018992312,0.015499072,-0.0052876733,0.026342858,-0.05193904,0.016221713,0.012578139,-0.039098207,-0.104010105,-0.04900101,-0.025165895,-0.061082847,0.10245388,-0.030942991,0.00049238786,0.016158015,-0.040423356,0.015345322,-0.050894585,0.0074186106,-0.019766347,0.045813434,0.09053517,0.047397997,0.012622985,0.09982181,0.075493924,0.09745298,0.008456713,-0.01711702,0.01030197,-0.03943266,-0.074509725,-0.08126997,0.02065064,-0.070331946,0.026282456,0.08067144,-0.04359991,0.0011044435,0.033390198,0.038015455,-0.048514877,-0.08050772,0.044046476,-0.04056602,0.101445556,0.07378053,0.008059623,0.02026487,0.022171443,0.030217506,0.024471728,-7.9528345e-06,0.058920585,0.04527351,-0.04417983,-0.057844162,-0.01020534,0.008789752,0.0038179208,0.026708974,0.03912704,-0.026297055,0.07184408,-0.11650716,4.6125586e-34,0.027142154,0.011032633,0.032317042,-0.040282175,-0.0019243095,0.032271393,-0.032732345,0.017276153,-0.01411396,-0.05146717,-0.06239343,-0.071560144,0.026931815,0.019038597,-0.003423908,0.0015435676,0.020368647,0.044524666,0.014199476,0.017705677,-0.014516184,0.048007116,0.03662468,-0.056381803,0.056418784,0.05307581,-0.035803,0.008242661,0.038073156,-0.021547595,0.01726396,-0.05022481,-0.08645723,0.08417366,0.099235125,-0.004312246,0.018536903,-0.046200633,-0.03296348,0.062943436,0.038197473,0.008518233,-0.008060755,-0.023071093,0.047691464,-0.10414991,-0.06607471,0.052605644,0.08339699,0.028304039,0.034179382,-0.01947212,0.081638984,-0.08329693,-0.019087251,0.07787827,0.013514138,0.027979847,0.11093363,0.0256407,-0.01735282,0.029496217,-0.062269088,0.055739153,0.046288606,0.03125853,-0.06850252,-0.06061103,-0.048917815,0.10027017,-0.066909134,0.026031889,0.04655799,0.01722595,0.010552202,-0.08945522,-0.115294546,-0.029340873,0.010417675,0.004506997,-0.07286828,-0.038064666,-0.009780062,-0.009472104,-0.05962063,0.024499228,-0.02128442,-0.042110305,-0.0045927097,0.031694263,0.08851288,-0.016040025,-0.11997016,0.04741414,0.0034606738,-2.8989441e-33,0.05074829,-0.10656007,0.007440737,-0.08486501,-0.037682492,0.059078537,-0.006083636,-0.045112617,0.025372822,0.014782007,0.043416783,0.027679525,0.008899257,-0.061826747,0.030562578,0.061359987,-0.019687202,0.094858654,-0.019923305,-0.038520508,0.0159432,0.060143996,0.05347425,-0.0071734227,0.021972226,-0.034822065,0.0018351754,0.06799537,0.018928418,0.019675821,-0.06944512,0.00033363808,-0.024334671,-0.10631498,-0.036047265,0.01630497,3.3427168e-06,-0.029681453,0.06953161,-0.009240756,-0.034475356,0.08046705,0.022112925,0.044741515,-0.023978895,0.12808456,-0.039754555,0.002663175,0.0007494253,-0.03673654,0.0069317888,-0.07539393,-0.022838598,-0.048436057,-0.027580768,-0.008711896,-0.071492285,0.0037930743,-0.063799426,-0.007175698,-0.001096413,-0.018932942,0.009092135,0.030754609,0.033842877,0.08833541,-0.04979826,0.029729115,-0.012219065,-0.03639815,0.07854936,-0.013417306,-0.090609446,0.02659926,-0.027549991,-0.0015172332,-0.09417821,-0.00079559407,0.039426077,0.004996902,0.054752707,0.01622824,-0.05982808,-0.08081388,0.0006593311,-0.061548304,-0.014037103,0.10614735,0.045830093,-0.0012195122,-0.095550925,0.01747451,-0.021053111,0.019784892,0.05944323,-2.9398764e-08,0.018379552,-0.031409524,0.07182919,-0.055543933,0.0063487384,-0.010853036,0.027991636,-0.005311535,0.08902064,-0.027484693,-0.070373066,0.07416116,-0.0014643345,-0.011190376,0.013474958,0.03211283,-0.024543675,0.00032878286,-0.03638574,0.035959087,0.00846907,-0.02224927,-0.06504851,0.03185631,-0.01580117,-0.07946634,0.019687362,0.033298474,-0.059186578,-0.06658169,-0.07574456,0.031026993,-0.014893482,-0.054175712,-0.023681628,0.057049,0.027306978,-0.021780053,-0.0038540773,0.032054026,0.042373125,-0.092769414,-0.061785445,-0.030471165,-0.013632153,0.10088991,-0.02739016,0.00043858023,-0.020890431,-0.010232914,-0.013435384,-0.030421091,-0.030903254,-0.042336673,-0.1134651,0.003391286,0.024549734,-0.119619146,-0.021095589,-0.08085485,0.023889707,0.046393894,0.21936584,-0.012863214 +2.8.3.22,"The enzyme, purified from the bacterium Chloroflexus aurantiacus, can also accept itaconate as acceptor, with lower efficiency. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.",384,0.99999994,-0.05259968,0.007726765,-0.1061764,-0.017941058,0.041708358,0.025645867,0.028478896,-0.02537971,0.009846345,0.018152451,0.023638299,-0.12182282,-0.032625925,0.020752585,-0.031228352,0.0009816104,-0.048629813,-0.03549172,0.023780553,-0.039810825,0.015544222,0.03233949,-0.08281021,-0.025641127,0.030114263,0.009845612,-0.03784311,-0.08997353,-0.016807893,-0.07709474,-0.04420362,0.0067053153,0.07370874,0.00902925,-0.011464347,0.066573784,-0.065663815,-0.069754556,0.059406757,0.007648961,0.0070883404,0.029046781,-0.0016346843,-0.033099473,-0.0910743,0.0038332127,0.020126367,0.0035583468,0.022841206,-0.06414231,-0.021584004,-0.024532111,-0.041590597,-0.025549434,-0.059048176,0.051018454,-0.00839683,0.00044246472,-0.01995648,-0.028240437,0.014291577,-0.029357469,0.0023607763,0.075601526,0.04917063,-0.09057575,0.03309336,-0.05404966,-0.044465356,-0.062165022,-0.058204234,-0.04982775,0.012295065,-0.015374869,0.065956034,0.06844648,0.030179203,0.0045653186,0.029442295,0.00094705465,-0.034263182,0.009686928,-0.031540927,0.048786733,-0.011486347,0.026966149,-0.021058794,-0.017235275,0.018594142,0.08761052,0.07848687,0.010669334,0.004912625,-0.03931024,-0.047848698,0.032373726,0.10807509,-0.012017679,0.07922844,-0.06583327,0.021639442,-0.0133578,-0.053321574,-0.122596584,-0.098071426,0.0021761262,0.01513911,-0.0052243266,0.07461825,-0.009434354,-0.09123992,0.028443588,0.029652104,0.0378541,0.01323082,0.113584824,0.042515043,-0.10978307,0.0077863564,-0.025430938,-0.056570612,-0.062920496,0.07544539,0.062317695,-0.06636882,0.04341217,-0.016221568,2.006718e-33,-0.0067767156,-0.003598705,0.008015846,-0.061965693,-0.015880283,0.00542996,-0.07020419,-0.010862752,-0.07753032,-0.11679462,-0.13545294,-0.027136358,0.0030378466,0.044265322,-0.01054454,-0.022159433,-0.036684286,-0.003148238,0.050579328,0.0013113972,0.026898004,0.02736602,-0.080527484,0.0033232842,0.04296971,0.03650298,0.045390803,0.024195032,0.040135927,-0.0016611349,0.077660285,-0.06285579,-0.07618727,0.037546072,0.082130276,0.0067325155,0.0483349,0.029971171,-0.06787355,0.00800382,0.009113094,0.054967944,-0.028908966,0.019287094,0.07645551,-0.02227542,-0.010738971,0.023436962,0.008471366,0.037311614,-0.053987753,0.019338166,0.07392103,-0.072380506,-0.003540812,0.10137557,0.058375783,0.02403601,0.01805564,0.0020951368,0.0059268028,0.10822794,-0.03482213,-0.0012603052,0.0017738413,0.117074266,-0.06373436,-0.056783136,0.02982564,-0.009441604,-0.11573374,-0.022255298,-0.048648767,0.05369995,0.045111798,-0.07815327,-0.016784385,0.021401478,-0.00091258745,-0.07163905,0.009773431,-0.023062361,0.0322006,0.03219887,-0.032707907,-0.022232022,0.0073425667,-0.022932729,-0.0017778052,0.055188444,0.13632353,-0.05061319,-0.021017024,-0.00922947,0.0581931,-3.6729695e-33,0.10817281,-0.13021141,0.022755554,0.000624928,0.015760805,0.07097498,0.0039666183,-0.006560483,0.016556785,-0.049881488,0.059439853,0.05753323,0.05272076,-0.015061059,0.014808583,-0.014557184,0.025444794,0.10017635,-0.06444886,0.012946945,-0.04250743,-0.008077277,0.060296044,-0.044901196,-0.02141921,0.040537678,-0.049083408,0.055334207,0.06708886,-0.016539445,-0.025015004,0.049692713,-0.024174973,-0.06373283,-0.041072816,-0.045567393,-0.09408854,-0.0043830196,0.009431582,0.04380286,-0.049265597,-0.03356853,-0.021980396,0.01748617,0.033516772,0.082852095,-0.047081165,-0.0053359624,0.005245688,0.028220167,0.070936315,0.038203705,0.03765747,0.051177803,0.13170512,-0.011411601,0.14451115,-0.004971493,0.020952761,-0.075710446,-0.058432262,-0.02593461,0.08021054,-0.045980893,0.071867004,0.030598985,-0.04210739,0.08839438,0.016785618,-0.042435557,0.12128096,-0.08089741,-0.021918384,0.0150960535,0.0012253111,0.02011433,-0.038585465,-0.030080559,0.013737039,0.022607569,-0.07429933,0.07711884,0.04455699,-0.05017765,0.039724033,-0.11961576,0.025257437,-0.037478805,-0.039931428,0.06863334,-0.025359092,-0.0151365725,-0.03158051,0.026795696,0.13440467,-3.6755175e-08,-0.050075367,-0.033861805,0.054898128,-0.013377163,-0.008830134,0.026416166,0.042488586,-0.021785725,0.05590095,-0.061597247,-0.008608069,0.036638666,0.082158856,-0.014868255,0.06471246,-0.008323519,-0.02916416,-0.014148721,-0.019600626,0.034097526,-0.11535954,-0.036156993,-0.10191577,-0.058945592,0.088254064,-0.016131226,0.03542155,0.033130657,0.0381863,-0.024436407,-0.094396114,0.022097725,-0.008391764,-0.028820077,-0.08985139,0.04372193,-0.04572838,-0.0441196,-0.037593294,0.028097484,0.067666054,0.0014303325,-0.072327815,-0.014973271,7.2607094e-05,0.06605515,0.03555822,0.015976256,-0.03322055,0.0026186353,-0.006775147,-0.04365976,0.025873471,-0.011674248,-0.08501627,0.009005047,-0.008845755,-0.066367276,-0.032261983,-0.03556412,-0.005853945,0.03866362,0.14484012,0.015331143 +2.8.4.3,"This bacterial enzyme binds two [4Fe-4S] clusters as well as the transferred sulfur [3]. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover. The identity of the electron donor is not known.",384,1.0,-0.03264635,-0.065718904,-0.13388939,0.061239053,0.04158761,0.032568045,-0.041756198,0.0457952,0.028334223,-0.06356207,0.045709167,-0.019051528,0.0004349645,0.06444981,-0.049512036,0.08238155,-0.09692051,0.008277995,-0.00597556,-0.048319478,-0.02501067,-0.011462722,-0.012041912,-0.08716226,0.047327098,0.10348438,0.07114345,-0.07472119,-0.04682305,-0.07011172,0.026874421,0.00083904143,0.034743268,-0.04144682,0.02514089,0.11007354,0.014224072,-0.05924642,0.058240227,-0.0004343521,0.020373745,0.010569552,0.027897758,-0.028590895,-0.032026242,-0.0023672283,0.004050004,0.0522877,0.06566943,-0.12411925,-0.005083534,-0.024802709,-0.051907662,0.11451291,-0.0066813002,0.014751894,-0.00970249,-0.055330534,0.032446697,-0.01986178,0.11439542,-0.008636112,0.02873492,-0.000958891,0.02955369,-0.034460824,0.0841497,-0.07837904,0.011415801,-0.048989635,-0.03854876,0.01362721,0.008850915,0.020960683,0.02122886,0.015728867,0.033377457,-0.054615594,0.11150542,-0.01599381,-0.008821558,-0.04346405,0.025818115,0.059077237,0.032425586,0.006795562,-0.024988806,-0.049263846,0.02573472,0.020366149,-0.05450213,-0.0099041425,-0.048830144,-0.057209354,-0.06833069,-0.007848779,-0.025976542,0.0769199,0.025176948,0.015669558,-0.018116843,0.059340086,-0.07167013,-0.059869416,-0.02904658,-0.04596952,0.027124273,0.089032374,0.011897324,0.04144865,0.045604803,0.008442513,0.04141267,-0.00597315,-0.065146945,0.08304615,0.03611504,-0.053591855,-0.0993404,0.006383635,0.016819084,0.033869907,0.01651462,0.041866444,0.003310847,-0.019832596,-0.18909347,-1.0767309e-33,0.080958955,0.06951836,0.06050752,-0.022701252,0.015124025,-0.044839922,-0.076293096,-0.008845414,-0.059696723,-0.018447082,-0.10324105,-0.07444877,0.096911095,-0.04332689,-0.06615946,-0.06678376,-0.026310988,0.02093168,0.06404448,-0.030789118,-0.034111038,0.03228011,-0.049332917,-0.014463185,0.025319036,0.025297966,0.013465854,0.0291887,0.07039143,0.026639465,-0.006740944,0.011960077,-0.10283663,-0.037697077,0.038001377,-0.025085673,-0.016572297,-0.09704657,0.012681179,-0.00387403,-0.017113859,0.022442274,0.023101538,-0.052715424,0.06469012,-0.030820824,-0.053939518,0.01779137,0.041606538,0.07654917,0.003697864,-0.07341754,0.12240393,-0.02360212,-0.079298615,-0.024657425,-0.0025403888,-0.012646319,0.028828086,0.034972336,0.014474126,0.022312108,-0.0927068,0.01816992,0.00024725558,0.041316908,0.040144224,-0.019064816,-0.0041161114,0.09609062,-0.035805196,0.027094547,0.052256558,0.032075312,-0.050393425,-0.0034596915,-0.0045772167,0.040247418,0.04455217,-0.03882243,-0.030062636,-0.078838125,-0.009004109,-0.048622612,-0.019248117,-0.0332321,-0.048385583,-0.056955993,-0.041785967,0.026121678,0.026897157,-0.03279861,-0.06627244,0.032910794,-0.022268774,-7.955655e-34,0.04363818,-0.017930288,0.012880817,-0.063421436,-0.06468909,0.055363294,0.005624927,0.035271082,0.021493914,0.046474952,0.10793618,9.062924e-05,0.040701285,-0.090049446,0.05369788,0.045656156,0.020210309,-0.03567802,0.016328996,-0.001262604,0.075530656,0.05700689,0.008736328,0.040021665,-0.0032484462,-0.00815743,0.03913413,0.009295822,0.03830603,0.08107153,0.02761637,-0.06941901,-0.047727518,-0.050635625,-0.014193332,0.015771007,0.017273622,0.016172763,0.06027193,-0.05716509,0.030529138,0.025803113,0.022003504,0.1717166,0.03312007,0.030626189,-0.0068683587,0.06873946,0.031083208,-0.037159905,-0.01738543,-0.03708236,0.0014537805,-0.028759921,-0.030280659,0.06665161,0.014396772,0.0035529726,-0.0461295,-0.038577303,-0.053298667,-0.12739846,0.07116462,-0.008826018,0.03514982,0.009311974,-0.028004551,-0.023943882,0.0023524554,0.008730979,-0.0015839081,-0.003200909,-0.01636016,0.0137451785,-0.06475786,-0.049208276,-0.055168513,0.0016293374,0.016758684,0.03387976,-0.0056691286,0.010178385,0.010342815,-0.095184445,0.08201443,-0.0895293,0.07148437,0.14637886,0.044847768,0.013624654,-0.07579473,0.032707784,0.01863691,-0.03575886,-0.01731781,-3.6695784e-08,0.028318238,-0.03482817,0.030499183,0.000795187,-0.0096818535,0.05635169,-0.04643844,0.005570918,0.019590477,0.030706026,-0.024548147,0.15235262,-0.063495316,-0.0057864133,0.05505705,0.0038232845,-0.097930856,-0.040516946,-0.024374112,-0.067300424,-0.023645267,-0.04591915,-0.061810065,0.04868258,0.04317052,-0.03742778,0.04675355,-0.007425255,-0.04531424,-0.0808273,0.028015802,0.024088379,-0.07414834,0.013417972,-0.1147484,-0.023724802,-0.08223452,-0.015614024,0.015847776,0.083624974,0.05055304,0.012480016,-0.07236173,0.06538852,-0.048598465,0.12140095,-0.040782154,0.030511394,-0.05099244,0.015850918,0.04929243,-0.0470817,-0.005820328,-0.018152487,-0.09604956,0.043798327,-0.020380953,0.017002892,0.11990678,0.008154703,0.020050846,-0.0053102,0.08057957,0.023094827 +2.8.4.4,"This bacterial enzyme binds two [4Fe-4S] clusters [2,3]. A bridge of five sulfur atoms is formed between the free Fe atoms of the two [4Fe-4S] clusters [6]. In the first reaction the enzyme transfers a methyl group from AdoMet to the external sulfur ion of the sulfur bridge. In the second reaction the enzyme catalyses the reductive fragmentation of a second molecule of AdoMet, yielding a 5'-deoxyadenosine radical, which then attacks the methylated sulfur atom of the polysulfide bridge, resulting in the transfer of a methylsulfanyl group to aspartate89 [5,6]. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes.",384,1.0,-0.049148474,-0.09132242,-0.100143544,0.07768524,0.067057595,0.018773828,-0.07949553,0.07826021,0.029023122,-0.059866484,0.020321222,0.0001280027,-0.04750435,0.049297865,-0.037250645,0.07987354,-0.10897421,0.024552338,0.005414097,-0.040583473,-0.002091125,-0.009077407,-0.026124878,-0.07176697,0.015875645,0.08292015,0.09444707,-0.037075106,-0.07590141,-0.08396994,0.001664539,-0.03762803,0.02873706,-0.019479135,0.017256323,0.13180408,0.02303071,-0.05538454,0.05141944,-0.04021809,-0.00080297026,0.041142426,0.012315435,-0.030246237,-0.02653972,-0.009745905,-0.011796841,0.05225681,0.043180034,-0.09123056,-0.049085274,0.006463132,-0.017513754,0.083514325,-0.033486694,0.013678464,-0.0013662783,-0.053977314,0.0072331186,-0.030568099,0.09367591,-0.016394103,-0.011668484,-0.006040809,-0.0072021703,-0.01128526,0.1058257,-0.035859514,0.0033588302,0.0041554994,-0.055167962,0.045156024,-0.018519735,0.023708928,0.034179974,0.008405582,-0.00031857577,-0.052841794,0.09683259,-0.018413242,-0.00082147605,-0.010378748,0.035314385,0.08984407,0.03065926,-0.01534596,-0.00704723,-0.005345151,0.06603671,0.051576585,-0.067390926,0.03398378,-0.03780074,-0.054773163,-0.03890794,-0.030274566,-0.020254882,0.057592683,0.004168667,0.012726642,-0.03708445,0.09642416,-0.07291195,-0.04173774,0.036558595,-0.04307772,-0.00645729,0.09063648,0.060439013,0.040875964,0.017446196,0.01365295,0.06363203,-0.022742026,-0.055359565,0.08449588,0.03971898,-0.057902843,-0.0947824,0.013754777,0.041545287,0.03883072,0.0010746539,0.04603351,-0.022326153,-0.0128707485,-0.2052708,1.26523205e-33,0.06260446,0.0527504,0.06619469,0.013849838,0.022421319,-0.03443608,-0.11095421,0.022905562,-0.026593471,0.011555342,-0.09324681,-0.1215363,0.1082782,-0.034695845,-0.0136158895,-0.060272455,-0.010778929,0.024986958,0.04073489,-0.0475942,-0.03349419,0.06303646,-0.06615757,-0.017629556,-0.011152544,0.007197352,0.025978478,0.037429,0.057985198,0.012418525,-0.04504147,-0.056353264,-0.11978859,0.012235502,0.060468778,0.007272825,-0.03278478,-0.08706042,0.002434555,-0.012696956,-0.010606645,0.016454946,0.016796779,-0.050101,0.07149763,-0.07073293,-0.06142381,0.050228007,0.060883008,0.10728771,0.017336661,-0.027125767,0.11322674,0.007947821,-0.10210726,-0.005258001,-0.02159607,-0.0032033473,0.009853954,0.086901754,0.039701167,0.0009815366,-0.061523683,0.01334503,-0.004058072,0.0400522,0.03387405,-0.025958506,-0.003484235,0.08002414,-0.06028198,0.026304873,0.074980594,0.056616608,-0.07434347,0.018748108,-0.0060659563,0.022707934,0.08833849,-0.021754919,-0.05876843,-0.05451135,0.029778898,-0.017330132,-0.0039936034,-0.029040983,-0.023483276,-0.06632346,-0.06664585,0.031265374,0.0024573363,-0.08775267,-0.07021692,0.04929867,-0.0035856452,-3.8006528e-33,0.025911145,-0.013041176,0.024956195,-0.113190584,-0.09555606,0.045018252,0.018791618,0.067786865,-0.0068266224,0.0030541387,0.10570283,0.024651276,0.030042274,-0.06312435,0.036605157,0.03556075,0.03672397,0.013977975,0.013172562,0.014976226,0.06242947,0.091553725,0.014137096,0.049127724,0.007663035,-0.0035536378,0.089250274,0.009078039,0.024526913,0.08022448,0.045274384,-0.03806171,-0.02117346,-0.042245038,0.004750953,0.030835766,-0.016453678,-0.017320674,0.030481571,-0.044704918,0.03067053,0.0062218476,-0.0199079,0.14356032,0.043005332,0.03802088,-0.051617023,0.04479119,0.0047846455,-0.058158908,-0.021319887,-0.03377327,0.0017955103,-0.013711586,-0.030770652,0.028331332,0.03666873,0.0035755653,-0.07768195,-0.009832379,-0.041928407,-0.06821664,0.04669616,-0.013933162,0.01158705,-0.007567176,-0.041544564,-0.024723155,-0.0015262008,0.0039606136,-0.03876011,0.041859183,-0.0058513205,0.02423732,-0.04321496,-0.06523577,-0.039836966,-0.0026706785,0.012746664,0.0320178,-0.0096839005,0.0022130036,0.035157114,-0.081918,0.0460772,-0.111010134,0.05789293,0.10731345,0.01524964,0.013115278,-0.05855531,0.007828549,-0.022588816,-0.005986304,-0.029695744,-4.3283585e-08,0.054359283,-0.052572083,0.04904812,-0.03542438,-0.029188884,0.055152733,-0.063259095,-0.0022645446,-0.037732884,0.0016932698,-0.0171313,0.111824945,-0.079639055,0.0042441715,-0.026675293,-0.01320022,-0.08688331,-0.02435968,-0.035634916,-0.074170575,-0.08667345,-0.038599554,-0.036378976,0.060910847,0.06305442,-0.04313041,0.018789424,-0.027298743,-0.00941108,-0.05559527,0.030067988,0.033437554,-0.074089766,0.022441829,-0.10438753,0.0021152166,-0.09009256,-0.023278069,0.020056456,0.09488552,0.053317,0.027355494,-0.06463171,0.07044155,0.014503128,0.09501707,-0.03360699,0.05129306,-0.022027427,0.0075368495,0.059328776,-0.0098257605,-0.008059202,-0.037885785,-0.11135603,0.034843594,-0.03733991,-0.033814233,0.043321535,0.026197677,0.011255284,-0.0047529303,0.093819395,0.00482888 +2.8.4.5,"The enzyme, which is a member of the S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes superfamily, binds two [4Fe-4S] clusters as well as the transferred sulfur. The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover. The identity of the electron donor is not known.",384,0.99999994,-0.021555083,-0.043442734,-0.12157405,0.08268433,0.06547148,0.051569186,-0.04047651,0.039282914,0.030611536,-0.049757745,0.03321933,-0.008930111,-0.015566738,0.04323751,-0.043381162,0.09647359,-0.09855924,0.013882758,-0.023283744,-0.06845173,-0.028019857,-0.050684337,0.005760088,-0.08423728,0.060826465,0.09051003,0.0513705,-0.07213999,-0.037711788,-0.061385665,0.021982463,-0.0075621083,0.004660402,-0.009133326,-0.02395773,0.12406246,0.0063721095,-0.03476623,0.008908462,-0.018497117,0.03026206,0.000433567,-0.0076380367,-0.010337596,-0.0399141,-0.048161075,-0.015420535,0.023752622,0.050155688,-0.088548504,0.015991788,-0.034960173,-0.059298683,0.09689326,-0.010424054,0.04277685,-0.0076822434,-0.035353735,0.029192831,-0.008846999,0.10849667,-0.021485658,-0.0007278754,-0.007287428,0.040541746,-0.031712517,0.09179122,-0.06509823,0.026538258,-0.058984444,-0.024833774,0.02188108,-0.011724299,-0.0040065907,0.0073512206,0.026245955,0.0046646674,-0.04655213,0.114307776,-0.0018608206,0.022430252,-0.019750586,0.036141966,0.027338095,0.062340014,0.03628534,-0.026141133,-0.0543365,0.009759607,0.0090811,-0.05177886,-0.021936044,-0.053674057,-0.024970973,-0.05877063,-0.00010022053,-0.019275066,0.09085275,0.01342606,0.031976353,-0.0063045654,0.05827991,-0.091730416,-0.06773547,-0.038021185,-0.043531545,0.0070091523,0.070302166,0.0039888644,0.051180433,0.03332694,0.00370562,0.052638434,0.012513511,-0.05296128,0.1030029,-0.0018034669,-0.038020086,-0.081775844,0.002114372,-0.0063995854,0.07186215,0.022987064,0.067864805,0.0280257,-0.02227391,-0.1860764,-1.5227321e-33,0.09988931,0.096751384,0.08290887,-0.012424905,-0.005637439,-0.053206526,-0.073742904,0.022438888,-0.03001806,-0.0076987054,-0.10407488,-0.06886773,0.09405512,-0.071874596,-0.081892334,-0.07550307,-0.03229782,0.011376012,0.07016253,-0.04509316,-0.073366605,0.022330523,-0.07297385,0.008003648,-0.014658875,0.024574863,-0.004878613,0.029855035,0.047923665,0.03593117,-0.044993803,0.031230481,-0.08192795,-0.012559503,0.012669332,-0.02289357,-0.01767781,-0.10405059,0.030203508,-0.011692312,-0.017265117,-0.007530686,0.042606324,-0.074800014,0.06006943,-0.047926623,-0.07462724,-0.006616919,0.03673504,0.07558215,-0.015137669,-0.08300703,0.12022298,-0.0019592897,-0.09547455,-0.026108483,-0.0021291713,-0.04713769,0.022927722,0.057341073,0.019281514,0.028837677,-0.07437899,0.024147686,-0.019836795,0.03485294,0.018564632,-0.010109476,-0.038108665,0.093529895,0.0026994622,0.031489406,0.048614096,0.026490038,-0.041831996,0.0070175678,0.023376103,0.063745745,0.02850159,-0.019836526,-0.025089381,-0.060899355,-0.03196952,-0.049540162,-0.01614657,-0.027007708,-0.042786382,-0.063406244,-0.018934583,0.030758103,0.0014868014,-0.022112269,-0.064383864,0.0061495434,-0.0033798544,-5.057478e-34,0.03726753,0.01219679,-0.009312282,-0.05688783,-0.035809595,0.05824529,0.032759048,0.008196505,0.03270438,0.04873595,0.094831906,-0.017496241,0.0378712,-0.12484271,0.056358445,0.03701712,0.010749387,-0.044877183,0.04046845,0.007040563,0.060238753,0.07313121,-0.0006346169,0.043734893,0.03683587,-0.037776116,0.05745454,-0.0045570983,0.07907007,0.08674405,0.04401297,-0.088224806,-0.053823043,-0.022627212,-0.010421762,0.028370908,0.014729628,0.03873802,0.049927913,-0.031507466,0.016895814,0.017102115,0.0436129,0.18818666,0.043584295,0.022674365,-0.007975493,0.063467234,0.034494188,-0.069935195,0.012264434,-0.033485625,-0.013775095,-0.026759077,-0.046082992,0.086668484,0.007112928,0.0029668862,-0.058635958,-0.031857617,-0.047983017,-0.11186224,0.05106691,-0.012360894,0.009795954,-0.012655033,-0.034380637,-0.029331015,-0.019265017,0.020357694,-0.00255187,-0.012169792,-0.016531857,0.03359172,-0.0657378,-0.05813657,-0.048201237,0.021071546,0.0021146126,0.0026836854,-0.012038221,0.032962896,0.028150186,-0.10930838,0.07391405,-0.082639806,0.050786946,0.13887082,0.05438801,0.013396585,-0.08000152,0.036268614,0.008609966,-0.027288133,-0.022195332,-3.9540012e-08,0.018281555,-0.021605417,0.033514567,0.004335615,-0.008328643,0.039800383,-0.019294865,0.008835919,0.008516229,0.03418064,-0.056070197,0.16586152,-0.05347116,0.003718774,0.039889377,0.0051381383,-0.08931036,-0.006822831,-0.02515032,-0.04803509,-0.028880635,-0.050021604,-0.06435147,0.036708664,0.019993426,-0.022749892,0.05700195,-0.0012853415,-0.028918361,-0.07546725,0.053661197,0.0038445,-0.07678103,0.005560115,-0.09487365,-0.0075820084,-0.049264904,-0.018782359,0.010947669,0.058707997,0.017257305,-0.012142433,-0.046303827,0.08345515,-0.054373946,0.09630358,-0.03690644,0.0013333573,-0.025997058,0.05614997,0.0378777,-0.030371131,-0.015774218,-0.059339758,-0.07668268,0.04001511,0.008268988,0.026987195,0.13798015,-0.02371106,0.03400212,-0.00066744763,0.08300847,0.014996485 +3.1.2.30,"Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters.",384,0.99999994,-0.053791232,-0.121390514,-0.05139903,0.041293968,0.055811122,0.006152478,-0.06538595,-0.020366607,-0.023585279,0.004168664,0.04401695,-0.034283478,0.020917391,0.016323594,0.07213285,0.03846099,-0.0120166,-0.0093496395,0.01488742,-0.025751326,0.11067278,0.026780916,-0.00978787,-0.012255552,0.07358967,0.014342221,0.07480703,-0.059717793,0.03458365,-0.019751059,-0.048682213,-0.021265397,0.06413363,-0.0708007,0.050219614,0.07980683,-0.038524132,-0.04399992,-0.03993808,0.0011864115,0.059593063,-0.070413284,0.0866676,-0.051536553,-0.07326557,-0.10950939,0.043563135,-0.08727466,0.008288518,0.055009406,-0.059708722,-0.07709204,-0.031076375,0.04437969,-0.012649381,0.006941611,-0.1180504,0.012904285,-0.03301303,0.023716362,-0.029398581,0.038546246,-0.03435781,0.0154224895,0.042077705,-0.005726187,0.018822093,-0.020042716,0.043371383,-0.05923992,0.042095874,-0.09346967,-0.056836013,-0.017339863,-0.03874907,-0.02479618,0.07295205,-0.06209835,0.0514282,0.034515172,-0.034638982,-0.04183635,0.10043208,0.08680849,-0.023354998,0.034716472,0.017451111,0.044414807,0.008221273,0.08062178,0.07135992,0.039680477,-0.08595744,0.032568164,-0.026431523,0.054264344,-0.025781719,0.0025242765,0.00026660517,0.037306674,0.0012918344,0.112131804,-0.09595279,-0.036544766,-0.050597545,0.036303587,-0.0038306122,0.06955558,-0.03371011,0.047948133,0.0921648,0.000622893,0.051348727,0.021007428,-0.019862264,0.059892762,0.017706618,-0.09461492,-0.0461801,0.03675391,0.04758308,0.0054841656,0.016641995,0.024270266,-0.03902086,0.06170689,-0.056518868,5.6477503e-34,0.02188468,-0.034430448,0.044694833,0.0064171366,-0.06832572,0.056156334,-0.02553185,0.052518692,0.015863013,-0.02011554,-0.085974485,-0.060438197,0.020155804,0.044782788,-0.015813354,-0.06179133,0.062291067,-0.03084228,0.11937831,0.012571479,0.017826812,0.07339453,-0.039907455,0.017710336,-0.024036849,0.09829889,0.035229787,-0.0002439561,0.0646334,0.01856185,0.010808115,-0.12063013,-0.0153341815,-0.007036916,0.01697757,0.005358698,-0.07370357,-0.00961656,-0.041087255,0.029647129,0.020500146,0.0012923632,-0.08441912,-0.035801817,0.0026882193,-0.06999369,-0.031367283,0.02456296,-0.02162175,0.04509283,0.0978546,0.03249452,0.0011006865,0.009391439,-0.06501918,0.071293905,-0.012258001,0.030243428,0.0043685585,-0.020177703,-0.024016539,0.005979292,0.056845214,0.03338844,0.093244016,0.040455468,-0.0681728,-0.11387583,-0.044241074,0.049822617,-0.06319597,-0.046810087,0.053803485,-0.029239934,0.03757878,-0.08103689,-0.07417842,0.043658428,0.06537668,0.027868127,0.05837541,-0.055849493,0.04437512,0.032067116,-0.056046836,0.0037383493,-0.03458817,-0.028068867,0.0056638457,0.003528878,0.055682532,-0.038529027,-0.035717454,0.037555452,-0.00078236184,-2.8496294e-33,0.07179993,-0.08281091,0.043937594,-0.10886838,-0.09381935,0.09018488,0.06579032,-0.066090405,0.018796803,0.024045123,0.1363395,0.024613848,-0.040962055,-0.07093185,0.016012905,0.034702934,0.019363742,0.100543685,-0.031123988,-0.007661134,-0.022355327,0.11205594,0.0340435,0.05584662,0.031215033,-0.029678043,-0.010261528,0.051582977,0.015296196,0.098255895,0.026768113,0.0029189482,-0.022680862,-0.06848334,-0.05022078,0.07948856,-0.018751713,-0.006357643,-0.01535217,0.045520756,-0.023744067,0.054870933,0.060545996,0.09938053,-0.00903434,-0.031124689,-0.060148202,-0.02529017,-0.014808885,-0.069534905,-0.044100415,-0.021039885,-0.06339004,-0.022538219,0.049874756,0.011336357,-0.03467002,-0.037049714,0.032791417,-0.062422045,-0.061938204,-0.025160907,-0.03331444,-0.0809148,0.066065416,0.09721987,-0.009366622,-0.025525786,0.058762573,0.017743384,0.09753483,0.017098974,0.04396178,0.006769687,-0.03935698,0.018647641,-0.056808893,-0.040685724,-0.021966457,-0.122966036,0.03394076,0.04545104,-0.03306756,-0.07869644,-0.030077338,-0.11388298,0.030988447,0.106008016,0.008059606,-0.0063832044,-0.066126786,-0.022118863,-0.029315341,0.02519293,0.06757898,-4.0435445e-08,-0.05457467,-0.08176153,7.579829e-05,-0.025615368,-0.0022125894,0.07702598,-0.029936526,-0.04446884,0.047269657,0.019839391,-0.020192064,-0.002233865,-0.028738327,0.028527476,0.08036907,-0.02549827,0.030548586,0.070616305,-0.064189345,-0.08010413,-0.07452855,-0.010591481,-0.07513779,0.041271612,-0.009254963,-0.041493528,0.0027684036,0.052341036,0.044261213,-0.0026932915,0.023002883,0.022648325,0.004958658,-0.011604862,-0.1003288,0.050383985,0.006058741,-0.026207302,-0.08606998,0.024284674,-0.027965475,-0.037757274,0.015934153,0.016494477,-0.04121187,-0.012650374,0.014191485,0.03360572,-0.028469915,0.0013809879,0.042672314,-0.066469796,-0.094744734,-0.032373283,-0.014856831,-0.032122303,-0.0068375985,-0.041667335,-0.033396702,-0.04946199,0.04247446,-0.012205733,0.06610843,-0.079293855 +3.1.3.93,"The enzyme from plants also has the activity of EC 3.1.3.25, inositol-phosphate phosphatase. The enzymes have very low activity with D-galactose 1-phosphate (cf. EC 3.1.3.94, D-galactose 1-phosphate phosphatase).",384,1.0,-0.039322194,-0.06368756,-0.048143428,-0.037758924,0.07679937,0.039201967,-0.020429458,0.019799063,0.07384416,0.056593977,0.034902263,-0.026560761,-0.08135497,0.021544138,0.0013190733,0.007461079,-0.024871584,0.011530072,-0.013312599,-0.013440215,0.1274164,-0.010759976,-0.0101209665,0.046728317,0.08046894,-0.08638837,0.019355169,-0.046508558,-0.06773618,-0.105954155,-0.075775035,-0.05403212,0.12629822,-0.022014717,-0.013733077,0.113881335,-0.010843592,-0.13194333,0.0048262053,0.00026110554,0.04175226,0.020134568,0.00015300978,-0.048103318,-0.061013203,0.0029502655,-0.049400277,0.026674394,0.06382642,-0.09534189,-0.05869812,-0.086293325,0.016016878,-0.056347664,-0.053381644,0.012411098,-0.046729546,0.08340498,-0.023846813,0.006064216,0.03387203,0.0047867037,0.07076979,0.04968096,0.0029898866,-0.03230163,-0.01615793,-0.039279304,-0.039977707,-0.01636716,-0.069624886,-0.102240846,0.0043323874,0.032500047,0.0068323533,0.046174258,0.008510169,-0.017297368,0.032027587,-0.03211155,0.022320842,-0.04866399,-0.07739904,0.041495137,0.014111451,0.03664035,-0.026144154,0.032856997,-0.015974283,0.013644399,0.058590252,-0.0456153,-0.02229337,0.020083794,0.02554195,0.097478256,0.009539777,0.023706635,0.026459035,-0.059983604,-0.007914708,0.11401852,-0.022757703,-0.054827344,-0.031441174,0.0872744,-0.018118888,0.007950253,-0.018121853,0.031110514,0.008728856,-0.09672298,0.025855869,0.017837832,-0.052287918,0.06798742,0.010798836,-0.09872784,-0.067225784,0.02414132,0.040787738,-0.11059379,0.049971744,0.060504287,-0.050060548,0.10353219,-0.05690392,6.4734116e-34,0.045703676,0.0069550658,0.0017000407,-0.054190416,0.008474937,0.008302238,-0.024198132,0.006658446,-0.06768096,-0.060551822,-0.084419206,-0.0052994858,0.080411196,-0.020898724,-0.028497173,-0.00036818575,0.02374894,-0.0028793241,0.063053064,0.009342074,0.021802662,-0.049241573,-0.103422984,0.046611406,0.04463268,0.017366005,-0.055208847,-0.011570925,0.06491188,-0.017365895,0.045798786,-0.10058251,-0.06992718,0.053562924,-0.009892912,-0.014019774,-0.05508366,-0.028987901,-0.029860025,0.027238188,0.0055444716,0.027789224,0.05501721,-0.037065335,-0.017823612,-0.025012752,-0.03768568,0.081625305,0.10181271,0.076924965,0.02214749,-0.017994048,0.065499164,-0.06442097,0.033320244,0.040260207,-0.021383313,0.011058368,0.055603325,0.054016992,-0.031409733,0.058282334,-0.045233656,0.023694536,0.010732842,0.056532394,-0.10252764,-0.03331254,-0.017307727,0.07905035,-0.042038873,-0.076889455,-0.0061315093,-0.0033238626,0.021745123,-0.0015844934,-0.020409813,-0.018756652,-0.061695207,0.054787077,0.027176041,-0.03895401,0.022893522,0.027221892,-0.030312585,0.036943015,-0.036658764,0.004045901,0.015535285,0.0515032,0.06974737,-0.043417014,-0.0587273,0.052423656,-0.0026487946,-1.5747152e-33,0.08704515,-0.038284782,0.06579733,-0.07670901,-0.03631319,0.08945472,0.03700186,-0.024615614,0.091046475,0.017292993,0.06939641,-0.022774361,-0.016067024,-0.06860917,0.00041621344,0.025703022,0.010408256,0.049547445,-0.013876678,0.041119568,-0.028555254,0.07991858,0.010221449,0.07692658,0.038739525,-0.010165648,-0.04510622,0.02515701,-0.04317154,-0.015056799,-0.01851465,0.025596974,-0.029402763,-0.013340402,-0.041463673,-0.025505709,-0.095904805,-0.042280555,0.028956821,0.02577611,-0.0010351127,0.07923654,0.08787319,0.014677739,0.02689825,0.065602496,-0.04896615,0.06777436,-0.019344274,0.0105689075,-0.04551704,0.020367496,0.020747313,0.12317204,0.07359929,0.059482,0.025726566,0.122439526,-0.01918719,-0.021891642,-0.00060553005,-0.07963352,-0.0030337698,0.00303575,0.039087635,0.050699335,-0.070815995,0.052835528,-0.013158211,0.028973997,0.039897893,-0.036357056,-0.0018293116,0.016787888,-0.04608625,-0.018103927,-0.11816578,-0.026084196,0.014879384,-0.024117446,0.046355247,0.07906522,-0.04327462,-0.0684874,-0.0036550884,-0.011851587,-0.037932027,0.08307493,0.023887267,0.07473093,-0.0926576,-0.047269218,-0.03128027,0.013926571,0.07527604,-3.657991e-08,0.05591055,-0.029753871,0.089001,-0.07523218,0.01987192,-0.044415686,0.03903699,0.06062008,0.041625164,0.029462576,-0.0454881,0.055672456,0.01357507,-0.034728967,0.07980106,-0.010479772,0.032125164,0.064335,-0.0048872465,0.024081228,-0.014317423,-0.017150197,-0.14122197,0.025313113,0.033617,-0.0040724697,0.055013057,0.033595983,-0.029161364,-0.002973263,-0.014885175,0.010554995,0.045438822,-0.027038727,-0.11587668,0.008359072,-0.048450068,0.008935557,-0.09541855,0.049692705,-0.0127252145,-0.09565811,0.01050848,-0.008655378,-0.063588396,0.018557707,0.029043283,0.028930394,0.021031255,-0.017567825,-0.0005790198,-0.07100862,-0.05741167,-0.09702939,-0.09591761,-0.040941924,0.05026755,-0.057280846,-0.02237451,-0.025480594,0.041537788,0.023608854,0.17247288,-0.011179067 +3.1.3.94,"The human enzyme also has the activity of EC 3.1.3.25, inositol-phosphate phosphatase. The enzyme has very low activity with L-galactose 1-phosphate (cf. EC 3.1.3.93, L-galactose 1-phosphate phosphatase).",384,1.0,-0.014487608,-0.07871001,-0.053979628,-0.033818364,0.040221043,-0.0063330927,0.008194294,0.04498809,0.052920617,0.040430214,0.006771095,-0.02267778,-0.10054298,0.07037314,0.009911812,-0.00083090767,-0.026244348,-0.025956964,0.008442352,-0.006872424,0.121850334,-0.025513109,-0.017676065,0.049195163,0.044074826,-0.093047105,0.08281279,-0.059704598,-0.06621602,-0.07725626,-0.056740962,-0.084731266,0.12898336,-0.04104564,-0.010412337,0.121590175,-0.040032636,-0.11995178,-0.026949937,0.024696063,0.039486337,-0.02745102,-0.03474902,-0.021554943,-0.029680092,-0.010770717,-0.04266724,-0.013882164,0.058860384,-0.008247838,-0.07481279,-0.041612573,-0.0018261997,-0.028759228,-0.059569955,-0.006703125,-0.09617785,0.05067471,-0.020903561,-0.007778687,-0.00037806472,0.007576973,0.078865506,0.07208635,0.0644653,-0.034475036,0.037386708,-0.08420807,-0.073246196,0.0070757098,-0.043743916,-0.088804595,0.018411888,0.042989355,0.029132059,0.012178783,0.010166917,-0.01980757,0.017481916,-0.018189395,0.04034344,-0.063072555,-0.0850995,0.035099138,0.017942868,0.03277129,-0.030294705,0.053189278,-0.05302246,0.041233737,0.024233839,-0.03810059,0.005264855,-0.004270806,0.029302767,0.07893128,-0.031999756,0.072316706,0.0221708,-0.046237037,-0.015584089,0.119542174,-0.02670491,-0.033350177,-0.017651882,0.09176022,0.021748267,0.019074108,-0.018077295,0.0340558,0.0336529,-0.08799928,0.016573628,0.02722282,-0.015284828,0.06076026,0.0040383046,-0.110761024,-0.044060826,0.06472748,0.053806067,-0.08623923,0.049213845,0.054999936,-0.0269085,0.09793527,-0.0366424,-2.239032e-34,0.016874779,-0.0011762393,0.04482662,-0.051457286,-0.013716338,0.04551571,-0.023760345,0.011628546,-0.0615853,-0.04053704,-0.038360946,-0.0067928825,0.06871269,0.02129197,-0.04932666,-0.00018213857,0.025598919,-0.0010344787,0.05144968,0.018093659,0.024907354,-0.049163602,-0.07185424,0.040075906,0.038258832,0.027914932,-0.0879561,0.011297023,0.045038324,-0.007870314,0.020492429,-0.071801595,-0.09148685,0.031624828,-0.028985487,-0.016234268,-0.046998255,-0.020921918,-0.025476182,0.035980802,0.010457557,0.029750872,0.03498183,-0.05846535,-0.0143964905,-0.053265836,-0.02632176,0.08115554,0.0676272,0.026423696,0.030945964,-0.035533335,0.04035939,-0.0819122,0.025544915,0.02505549,-0.032698907,0.002716738,0.022919899,0.06478313,0.008521928,0.06887075,-0.03441403,0.042930685,-0.007023065,0.012989108,-0.07482109,-0.05925229,-0.047404855,0.07732384,-0.03232258,-0.053062383,0.021060877,0.0032149216,0.01818707,-0.0024408507,-0.008540995,-0.008734513,-0.064149834,0.046496294,0.018588765,-0.059040654,0.027056046,0.034934714,-0.0433701,0.030726954,0.009382255,-0.018657217,0.012089624,0.054248083,0.04842797,-0.0748629,-0.076305605,0.058728036,-0.021044219,-1.9733114e-33,0.06077902,-0.064359345,0.07562146,-0.10779975,-0.027734414,0.10158776,0.10781046,-0.00630061,0.080674134,0.03536338,0.10969926,-0.042976417,0.016453095,-0.096068285,0.0384305,0.035316613,-0.01687006,0.0313457,0.01878292,0.016664974,-0.015479533,0.08444849,0.0030994746,0.082165875,0.028867358,-0.0072268774,-0.06231929,0.02732863,-0.019935822,-0.00016593837,-0.07340686,0.017017454,-0.047373872,-0.07765218,-0.024493309,-0.025752349,-0.090440616,-0.020126136,0.043909352,-0.0029426238,0.011567994,0.112220444,0.08661136,0.0068042236,0.018071169,0.09091621,-0.035400625,0.019784356,-0.044844277,0.0010270078,-0.041783836,0.016472328,-0.023176314,0.076729625,0.050744344,0.066982605,0.00033013796,0.055264257,0.027092366,-0.029308023,-0.028326876,-0.06347775,0.001591522,0.021836264,0.029771911,0.020602742,-0.07123016,0.033534177,-0.010352573,0.016952988,0.03988407,-0.0744125,-0.0005838863,0.005305738,-0.01967071,-0.017434891,-0.1321151,-0.036936425,0.07169583,-0.06397141,0.045432534,0.0602344,-0.0641855,-0.061508916,-0.0013025681,-0.027410347,-0.019233044,0.10248343,0.0073329005,0.07491798,-0.10974802,-0.037526693,-0.08308778,-0.015884914,0.018413987,-3.712914e-08,0.06944241,-0.021781063,0.093994096,-0.050318446,0.017632402,-0.010497206,0.035124555,0.058575686,0.04240793,0.033741407,-0.055143267,0.03959227,0.042788193,-0.028041923,0.08110072,0.020905519,-0.022805922,0.060448844,0.0043699867,-0.015451396,-0.004263676,-0.013055995,-0.11600039,0.03685404,0.044250797,0.027736051,0.03339905,0.057843264,-0.059333943,-0.027168527,-0.037193,0.016466603,0.04185917,0.0036132662,-0.10400528,0.0056024157,-0.046721637,0.031381432,-0.11261809,0.052025437,-0.03511952,-0.08635196,-0.0027586906,-0.0023074746,-0.03356405,0.019564271,0.04610546,0.03202771,0.013675688,-0.048833508,0.0019874054,-0.093432344,-0.08633164,-0.046228066,-0.05699213,-0.053937797,0.021513924,-0.06598148,0.012139792,-0.072985776,0.08001896,0.051646482,0.15998615,-0.017722145 +3.1.3.95,The enzyme is found in both plants and animals. It also has the activity of EC 3.1.3.64 (phosphatidylinositol-3-phosphatase).,384,1.0,-0.031931713,-0.024288064,-0.08611052,-0.01468511,0.08791423,0.091313325,-0.065276496,0.005118445,0.06601164,0.010350015,0.065257,-0.06011303,-0.07569413,0.0058334866,-0.0041370206,0.00784169,-0.06065446,-0.018891448,0.00010431403,-0.057091635,0.056110065,0.027489044,0.021051975,0.038284644,0.013025527,-0.04930453,0.0042759776,-0.029413102,-0.018706443,-0.08662387,-0.037564896,-0.042868793,0.1120948,-0.010846516,0.0020669205,0.05596887,-0.027439509,-0.15124734,0.049209286,0.043457516,0.047001272,-0.010256055,0.0024649822,-0.05635539,-0.033394508,0.0075342893,-0.029514387,0.0059712194,0.111662105,-0.061449695,-0.031237738,-0.09653655,-0.005640242,0.022274025,-0.074777104,0.025746118,-0.03330698,0.048894227,-0.04672101,0.049864803,0.035623334,0.010089265,0.070429936,0.05351745,0.0050059673,-0.027925575,-0.025652474,-0.07546184,0.0131239565,-0.052354842,-0.026949124,-0.12958898,0.019082967,0.024121871,-0.025621906,0.049998973,0.032087345,-0.015284964,0.06376269,-0.051354934,-0.0075502056,-0.028691577,-0.04717018,0.047766574,0.044880055,0.027667023,-0.03434615,0.032259356,-0.013745661,0.024111435,0.05147857,-0.06568182,-0.049866028,-0.008910591,0.0032835407,0.09287817,-0.006655741,0.04602105,0.06442802,-0.07406677,-0.00708201,0.065444164,-0.030741114,-0.056334004,-0.035214055,0.078012116,-0.030115731,0.027327364,0.0050352975,-0.0052108993,-0.03834831,-0.027060913,0.03291352,0.021594591,0.050348602,0.09441181,0.0052777994,-0.091487505,-0.014042821,0.005359842,0.032781318,-0.069605656,0.05518451,0.060147777,-0.027146848,0.08300126,-0.11741862,-1.5978089e-33,0.036712423,-0.01997205,-0.008426534,-0.058310285,-0.007174438,0.04298775,-0.019209541,0.053982656,-0.08460656,-0.0962008,-0.0743021,-0.007931261,0.07529937,0.02039663,-0.03656242,-0.032710254,0.018588709,-0.018526088,0.06320334,-0.021853626,0.05455961,-0.046890836,-0.05869254,0.045781795,0.023162713,0.030812435,-0.039613787,-0.0397966,0.07344114,-0.010726991,0.020476548,-0.11245669,-0.09114115,0.059826408,-0.028053217,-0.020606728,-0.014042682,-0.061626326,-0.050640162,0.068466336,0.03917751,0.021628093,0.0678874,-0.032002643,0.02794021,-0.035504654,-0.09086711,0.09497603,0.13990518,0.055518854,0.038093895,-0.020927086,0.13354269,-0.04457362,0.029633824,0.051651176,-0.042042788,0.019032378,0.031814158,0.023551675,-0.006164001,0.0832646,-0.019363046,0.020282423,0.06067988,0.08606829,-0.112822756,-0.04665903,-0.037971485,0.09196093,-0.033541307,-0.039725497,-0.0018236933,0.00013309327,0.041417737,-0.053616244,-0.070532195,0.0079954695,-0.043904196,0.04653756,-0.01708361,-0.031709928,0.026812414,0.05856386,-0.058282305,0.012393207,0.0058284937,-0.0051159044,0.020136515,0.039943513,0.06921687,-0.03015843,-0.0670645,0.039391678,-0.0007223472,-2.9450404e-34,0.07929072,-0.06718854,0.057447307,-0.06538455,-0.044286855,0.08544649,-0.0023950092,-0.01444181,0.104524046,0.043418944,0.0510672,-0.005417636,0.02625249,-0.07729772,0.04375763,0.021379191,-0.057443626,0.033374142,0.021873113,0.0035847803,-0.08094527,0.030079907,0.0066644875,0.052306764,0.06485412,-0.02682743,-0.017859574,0.01164301,-0.027108654,-0.036023363,-0.06235014,0.0045816586,-0.055392083,-0.011318522,-0.011088159,-0.007864088,-0.07965775,-0.076708466,0.044122927,0.0132859275,0.012155325,0.050235372,0.042137682,0.030034442,0.046019368,0.106232464,-0.04392479,0.08550583,-0.057913072,0.021780496,-0.010450685,-0.003920044,-0.0023310937,0.039904486,0.05840671,0.07456751,-0.01751837,0.06366241,-0.014111228,-0.049846668,0.010775155,-0.046978306,-0.013237517,0.05171351,-0.0025304751,0.058253914,-0.054320954,0.033304553,-0.005323402,0.026630677,0.06751371,0.031566992,-0.013613855,0.026232962,-0.049125448,0.027150491,-0.05428944,-0.020773368,0.020185051,-0.03813286,0.054361757,0.0137696,0.0066512357,-0.07078223,-0.018697705,-0.0412177,-0.024020651,0.10012464,0.03101276,0.022745373,-0.07024617,-0.05571086,-0.087274864,-0.006099243,0.10239243,-3.0687413e-08,0.050485615,-0.04592153,0.06969986,-0.09567395,0.03917496,-0.014322006,0.05224959,0.0071117864,0.02291988,0.044138618,-0.019508747,0.014454857,0.011134178,-0.022836441,0.060177103,-0.040160682,0.041549724,0.060845435,0.008702571,0.06390196,-0.032666575,-0.016058031,-0.09192286,0.011850839,0.014299165,-0.04114862,0.03682267,0.039730754,-0.024805961,-0.025831215,-0.023838865,0.016993707,0.033116337,-0.03556699,-0.036087904,0.011269459,-0.052122194,-0.04491678,-0.072698414,0.0454107,0.018866155,-0.067567974,0.0006672856,-0.063517876,-0.019427707,0.025641048,0.03840622,-0.01028107,0.008114141,-0.039104726,-0.027852822,-0.043416657,-0.0093443245,-0.081963904,-0.112470806,-0.042832747,-0.006915931,-0.12587635,-0.016672684,-0.06171181,-0.004844446,0.074743815,0.20168085,-0.0006041309 +3.1.21.8,"Requires Mg2+. This phage T4 enzyme is involved in degradation of host DNA. The enzyme primarily catalyses nicking of the bottom strand of double stranded DNA between the first and second base pair to the right of a top-strand CCGC motif. Double-stranded breaks are produced 5- to 10-fold less frequently [3]. It does not cleave the T4 native DNA, which contains 5-hydroxymethylcytosine instead of cytosine.",384,1.0,-0.04906038,0.010548666,0.043327384,-0.053793877,0.057040907,-0.07436264,-0.053787123,0.0367876,-0.06678957,0.03820292,0.021805322,0.06615021,-0.05867562,-0.009256935,-0.03473808,0.05335288,-0.053044796,0.040740848,0.0038567183,-0.08836331,0.056819357,-0.012940135,0.05233043,-0.0002738832,-0.038225107,0.021223055,-0.021385223,-0.022880977,0.049982987,-0.040677603,-0.015463042,0.038150504,-0.027170617,-0.028806077,0.055303827,0.045318723,-0.010960235,0.04091212,0.01493662,-0.010969029,0.09168043,-0.006239237,0.01797127,0.0021397835,0.019119948,-0.033121448,0.0705228,-0.017741865,0.00068707025,0.01613101,0.0030970748,0.061035626,-0.013590843,0.03394445,-0.026803635,0.05223218,-0.08821303,-0.0115079805,0.020560967,0.06915009,0.058586985,0.034901783,-0.035085622,-0.014853434,0.16144584,-0.023138855,0.03034805,-0.069412485,-0.0049648983,-0.023380132,-0.03375134,-0.05785273,-0.06390944,0.026759632,-0.04034133,0.051491585,0.014110669,-0.1119014,0.049252123,0.07628424,-0.042668376,-0.04916098,0.08155184,0.021508034,-0.0074450416,-0.038659707,0.07520808,0.047138155,0.010975711,0.086495526,0.04396677,0.077328384,0.025553396,0.0064446013,-0.05054908,0.07152135,-0.050107677,-0.006721688,0.05321721,-0.03931473,-0.025989814,0.014931822,0.008461974,-0.012993066,-0.028381819,-0.028524319,0.008596427,0.042109087,0.07196403,0.01420808,0.047645178,0.10614432,0.034512073,0.012461512,0.024758987,0.01761649,-0.03800864,-0.000714595,0.0005498617,-0.01934855,-0.005525941,-0.04744169,-0.011200902,0.016378636,-0.027782228,-0.0037638661,0.0043834257,3.2563302e-33,0.036314484,0.07137901,0.049394615,0.019003699,-0.057665378,0.05791099,-0.085655324,-0.019979633,-0.108906105,0.043620165,-0.019991327,-0.11045049,0.019949906,0.024579704,-0.019261545,-0.03775657,-0.013270844,-0.0060583185,0.045324862,0.04717163,-0.07261461,0.078418285,-0.0123396525,0.025559537,0.06442074,0.10506401,-0.039342195,-0.061463308,0.063460544,0.0015849256,-0.0076148612,-0.054421213,-0.08384264,0.03878632,0.044769064,0.050680257,-0.018156458,-0.016074264,-0.019348785,0.10844008,-0.09450497,-0.01591819,0.030349365,-0.02666378,0.05805288,-0.10888921,7.0894435e-05,-0.006751352,-0.07482689,0.06048996,0.013841496,-0.011128664,0.027033113,0.026649207,-0.06283263,0.013931573,0.004858139,-0.06405293,0.05431608,0.046569686,0.035416607,-0.009801957,-0.06279811,0.017772412,0.07616332,-0.006906998,0.012523757,-0.077787794,-0.029868461,0.068456516,-0.009351017,-0.051889647,0.029048447,-0.022449154,0.004053253,-0.012027673,-0.021896275,0.015930641,0.057779137,0.008801949,-0.06776011,-0.037649743,0.043417998,-0.05732027,-0.03405096,-0.031956367,-0.04861515,-0.040117417,0.046809584,0.015656494,0.07378302,-0.07663327,-0.03400833,0.0092721945,0.0079409275,-3.4840793e-33,0.077702604,-0.04868585,0.020591792,-0.011141569,-0.10153727,-0.049956903,0.032048233,-0.0001065295,0.013176332,-0.039917927,0.09742397,-0.09284277,-0.043759845,-0.058138303,0.0051705576,-0.06248533,0.017575826,0.07224079,-0.0230315,-0.049334608,0.047449782,0.10594664,-0.010266879,0.104952626,0.09742474,0.0123718,-0.0056520756,0.043422323,0.06550069,-0.002280265,-0.058539655,0.05955331,0.043068897,0.046906423,-0.0002988541,0.093397945,-0.050166965,0.051592294,0.052293457,0.022482134,0.036819525,0.07051606,0.0016335738,0.07453931,-0.021622641,0.055034082,-0.034115564,0.09429113,0.08850745,-0.015776586,0.08027136,-0.022043584,-0.03700666,-0.08177153,0.03326671,0.0064922334,-0.027673796,-0.053075567,-0.06527009,-0.021742841,0.022703938,-0.072779454,0.09095699,-0.023408206,0.043366507,0.04299037,-0.008141389,0.0473289,-0.0058565894,-0.014633006,0.026036609,0.047786452,0.04906363,-0.052815076,0.0019783692,0.0460514,-0.14040318,-0.0660842,0.054754097,-0.07478568,-0.020081852,-0.0012781986,0.007046511,-0.0686006,0.043901496,-0.10803182,-0.018226208,0.088254265,0.032274142,-0.026773952,-0.043954212,0.011325877,-0.04746795,0.05182832,-0.040050536,-4.3042206e-08,0.050350774,-0.082769565,-0.045070354,-0.046722278,-0.02453344,0.09473171,0.025330998,0.0059089777,0.13325515,-0.05018617,-0.036772758,0.02070716,-0.06693793,0.0016197666,0.058941126,-0.022447424,-0.10363943,-0.040206872,-0.051047437,-0.052656226,-0.13346319,-0.048934788,-0.11429179,0.05690274,-0.05275794,0.027863596,0.038444314,0.06644867,0.015092728,-0.05975728,0.05098388,-0.0264909,-0.024600722,0.056349598,-0.047055367,0.029870909,-0.030819163,-0.022495534,-0.008725772,-0.0036790608,-0.06007417,-0.009754871,-0.014472087,-0.02261059,-0.06702243,-0.061880503,-0.002249493,0.05209595,-0.03046353,0.019265605,0.010198067,-0.029021755,-0.06346136,-0.07402233,-0.025604978,-0.008557093,0.10118141,-0.013354429,-0.015604426,-0.0757712,-0.015203194,-0.017735366,0.14548846,-0.08043215 +3.1.21.9,"This phage T4 enzyme is involved in degradation of host DNA. The enzyme does not cleave double-stranded DNA or native T4 DNA, which contains 5-hydroxymethylcytosine instead of cytosine.",384,1.0,0.022260591,0.058501933,0.017288202,-0.10324919,0.053136513,-0.0617587,-0.049363997,0.024320852,-0.0020726435,0.012717457,0.009244337,0.06378811,-0.056943737,0.056478955,-0.0743968,0.07793093,-0.08004334,0.010045336,0.0007454821,-0.06644062,0.0009363367,0.03960617,0.0396703,0.01573791,-0.03553506,0.019241286,-0.027848108,-0.024017353,0.017923344,-0.039679985,-0.030102761,0.041706704,-0.08460249,0.0022668582,0.04465091,0.046743266,0.0031025023,0.006206328,0.04530852,0.055806477,0.1167056,0.019868594,-0.06955377,0.012569327,-0.02831024,0.01836391,-0.023215778,-0.023169655,-0.016416755,-0.025547726,0.0025709856,0.029317716,0.016228689,0.025191847,-0.06933724,0.069819175,-0.059414804,-0.0051714354,0.004703933,0.07651333,0.05839525,0.024486214,0.025683783,0.014398338,0.12476946,-0.03239186,0.0152801,-0.06252314,-0.042162538,-0.050158467,-0.056732215,-0.06012202,0.0014932484,0.0690439,-0.005543856,0.037550136,0.006106436,-0.060070604,0.01055287,0.0639246,-0.024723059,-0.068623446,-0.019463146,0.0012963202,-0.021536995,-0.057515454,0.042280585,-0.0017941769,0.0036263503,0.058915034,0.010873822,0.02657099,0.0031107417,-0.037893176,-0.055878386,0.05175738,-0.03297292,-0.011546054,0.050085936,-0.049162477,-0.051228117,0.022209337,-0.041559022,-0.04724485,-0.045888595,0.007641171,0.05296458,0.03888596,0.033752915,-0.0077930363,-0.024516707,0.078475796,0.0741229,0.009309982,0.03766045,0.008553365,-0.024216691,0.021190444,-0.008369031,-0.037721686,0.015836162,-0.059033312,0.032511145,0.005360595,0.012608467,0.0049520163,-0.002263161,2.451745e-33,0.07713724,0.05353382,0.027467646,0.0150153395,-0.0034906967,0.018516717,-0.0362507,-0.0014156594,-0.12070668,-0.04671268,-0.019746799,-0.13473321,0.02763186,0.0075158505,-0.025313552,0.026093865,-0.02548887,0.029912002,0.059716098,0.07560205,0.014539192,0.06750797,-0.020862866,0.029038986,0.06653602,0.062069762,-0.059187636,0.0055098147,0.047936726,-0.011970759,-0.046401326,-0.027256526,-0.11609457,-0.0009919811,0.053699408,0.07815838,0.025446864,4.3003798e-05,-0.010779866,0.10177768,-0.040882353,-0.013398859,0.056314886,-0.04213473,0.061726034,-0.10199015,-0.02205804,0.014878335,-0.064849705,0.032178357,-0.012760417,-0.061261956,0.054640986,-0.035174616,-0.029368713,0.0030546712,0.019352086,-0.04157316,0.00076933834,0.017387908,0.03190245,-0.013345658,-0.10860818,-0.014124304,0.0833749,-0.026320374,0.032591753,-0.08828119,-0.043608703,0.0757351,0.01021157,-0.014445683,0.020967297,0.011029348,0.03304316,-0.053917058,-0.03016092,-0.0011791456,0.040890772,0.016397558,-0.056862995,-0.08283839,0.026564084,-0.024298588,-0.03370785,-0.051093277,0.021808589,-0.015298099,0.046127062,-0.00024640374,0.07976635,-0.08116626,-0.065010965,0.0018893393,0.009095423,-3.3008862e-33,0.06929345,-0.043175556,0.007823868,0.01679232,-0.077202775,-0.022097854,0.023744969,0.045066193,-0.0120963715,-0.06948693,0.11241099,-0.114417255,-0.03944345,-0.064216286,0.030282555,0.031744305,-0.0065676165,0.012412097,-0.02860448,-0.012456148,-0.018802788,0.11150518,0.0007805871,0.093310684,0.07952665,-0.0077093383,-0.04519375,0.0791993,0.040585596,-0.05625004,-0.056729753,0.010693335,0.049570814,0.02498249,0.010260413,0.08065105,-0.025960585,0.010587701,0.04740336,-0.031372335,0.04904999,0.06251328,0.008893951,0.050331227,-0.019246181,0.08076672,-0.06341665,0.066680126,0.076611295,0.011023569,0.082013756,0.000991153,-0.0065341177,-0.056389626,-0.00019128366,0.032405134,-0.0069564776,-0.02894701,-0.065089226,-0.029950894,0.04201018,-0.0960533,0.041082848,0.06258487,0.025622563,0.041415174,-0.03267869,0.068222806,0.008214158,-0.059590694,0.019305341,0.0036213927,0.0225569,-0.017767325,0.029383784,-0.013551911,-0.18330854,-0.022047024,0.049165025,0.005471934,0.0061240485,0.0064442633,-0.016395966,-0.11071628,0.07171021,-0.029221963,-0.017543364,0.09395332,-0.01847972,0.021206245,-0.000756308,-0.0035010097,-0.06433322,0.028803375,-0.0034224198,-3.313291e-08,0.13534907,-0.05668382,-0.03515866,-0.039606377,-0.08426572,0.009468948,0.030104358,0.022714674,0.13521609,0.0009384928,-0.09239885,0.024466585,-0.059285525,0.01461593,0.09436519,0.005957621,-0.14065726,-0.06709162,-0.022818513,-0.014089381,-0.105791956,-0.01702737,-0.13502948,0.06758751,0.006872495,0.065636516,0.05401501,0.03498165,0.035726815,-0.07605544,0.055794783,0.018765949,0.020772904,0.03696516,-0.03274141,0.023772553,-0.00040106496,-0.03969841,-0.031001065,0.109776385,-0.053302914,-0.010630717,-0.09021535,-0.051791318,-0.009136362,-0.054817006,0.0100774905,0.04206094,-0.01009492,-0.036630906,0.025993561,-0.02295148,-0.071435116,-0.069152616,-0.0399186,-0.026337156,0.089464724,-0.026111383,0.017459802,-0.0865101,0.00591163,0.019392906,0.18719323,-0.064995505 +3.2.1.191,"Ginsenosidase type III catalyses the sequential hydrolysis of the 3-O-beta-D-(1->2)-glucopyranosyl bond followed by hydrolysis of the 3-O-beta-D-glucopyranosyl bond of protopanaxadiol ginsenosides. When acting for example on ginsenoside Rb1 the enzyme first generates ginsenoside XVII, and subsequently ginsenoside LXXV.",384,0.99999994,-0.04878523,-0.10426315,-0.08192771,-0.020117594,0.015511545,-0.036414493,-0.05763655,0.032894466,0.09455989,0.07776538,-0.037097525,0.119681776,-0.06414355,0.051035546,-0.05864235,0.018012276,-0.049305778,0.100534454,-0.025434831,0.017263584,0.09940949,-0.03916257,0.0551125,0.03280875,0.13867544,0.016078388,0.05185915,-0.07136,0.01903903,0.044739116,-0.00455461,-0.05859798,0.08143626,-0.07242765,0.04544962,0.004144103,-0.06562359,-0.07391945,0.0368503,0.002653893,0.039997518,0.028557666,0.00643393,-0.03754341,-0.033138815,-0.065567896,-0.08020884,0.046303153,0.08435646,0.018915698,0.050057814,-0.078606084,-0.06988326,-0.018641116,-0.049412146,-0.037170134,-0.05150703,0.018324895,0.07516378,0.16674985,0.0735146,0.058214393,-0.050920337,0.010861104,0.021343702,-0.022841444,-0.024103124,0.049794305,-0.03233914,-0.012155339,-0.030852629,-0.047081918,-1.57856e-05,-0.0423329,0.0654274,-0.04417468,0.012031418,0.014558834,0.006018318,-0.06944825,0.046809807,-0.0069856187,0.02964358,0.12543312,-0.019432375,0.07211309,-0.0069220965,0.1016948,0.0700029,-0.013158991,-0.06547335,-0.047245428,-0.02045862,0.05975309,0.06339325,0.026073309,0.09339446,0.018331822,0.005458303,-0.030739484,0.0048905667,0.04541278,0.007128958,-0.06866273,0.021291744,0.070398234,-0.06498075,0.07679112,0.056464933,0.018762372,0.029213259,0.024807638,0.023602214,0.00038155902,-0.1351792,0.030383406,-0.02792951,-0.025207112,-0.016803648,-0.014476655,0.056659482,-0.05372884,0.013073485,-0.028805204,-0.08892926,0.029003331,0.06899159,4.4790927e-33,-0.021557882,-0.0029249096,0.008195901,0.02630398,-0.053557925,0.06887868,-0.07889527,-0.09205084,-0.042053565,0.02100804,-0.08057424,-0.022257706,-0.023429302,0.0024428584,-0.04566482,0.014189659,0.012867565,-0.00040459793,0.006893953,0.06889062,0.06539038,0.072020486,-0.13186464,0.0544823,0.019719262,0.023613935,-0.029584186,0.017029008,0.04490275,-0.022638837,-0.03420357,-0.013039131,-0.069040395,-0.003444512,-0.0050099096,0.050530683,-0.054005392,-0.10381222,0.023008544,-0.02177307,-0.042259477,0.006356403,-0.06363318,-0.028646875,0.018429073,-0.0349291,-0.01417874,0.033427224,-0.021414148,0.085719086,-0.03251767,0.091084905,0.031700898,0.086596295,-0.04386843,-0.0644239,0.008082841,-0.017100424,0.06122136,0.020929204,-0.008895495,0.0002286382,0.0066014384,0.015383455,-0.030176274,0.051156554,-0.092233635,0.026187412,-0.022763183,0.05298934,-0.10281964,-0.0043175737,-0.07399314,-0.005024778,0.015111082,-0.055141363,0.05415552,0.06628471,-0.0020715485,-0.0049585504,-0.014613609,0.00533233,0.012578976,0.038165446,-0.049734764,0.03596335,-0.03942379,-0.049845524,-0.036160044,0.028659107,0.0138438195,-0.027710795,-0.041614212,0.0841829,0.01305447,-4.9255237e-33,0.08986378,-0.08969103,0.050434507,-0.109318905,-0.053728767,-0.010740877,-0.035901938,-0.08437246,-0.062441334,-0.04138956,0.017094124,0.016228173,-0.05219155,0.012144403,-0.055536598,-0.008672838,0.0044300156,0.026240248,-0.064098604,0.04245739,0.038747646,0.12280401,0.03349248,0.018386839,-0.029491311,-0.046767876,0.018068835,-0.02585294,-0.00096808834,0.085716054,0.05082876,0.0036970584,-0.024959363,0.040431343,0.023373881,0.0859125,0.06541424,-0.04141578,0.0071669007,-0.0077808667,-0.031385582,0.044579007,0.016480314,0.010692081,0.080456905,0.08380538,-0.09149751,0.060770493,-0.054913804,0.0083640935,-0.015025292,0.044242773,-0.025415767,0.037347544,0.054426257,-0.08020422,0.022571104,-0.025364274,-0.03057803,-0.039773546,-0.020458007,-0.024538133,0.051593643,-0.006651288,0.051499095,-0.0009092647,-0.08477943,0.1336158,0.048143506,0.019620167,0.032262005,-0.013398141,0.0053484756,0.053788725,0.029256199,-0.034241512,-0.03231743,-0.06884287,-0.00022649993,-0.07687859,0.027438847,0.07257422,0.03321166,0.01898024,-0.04992405,-0.035560828,0.04340696,0.10207477,-0.018690169,0.04971614,-0.0007227156,-0.0010733177,-0.014318371,0.082274385,0.13489136,-3.7920337e-08,-0.02620618,0.027619118,-0.0023109647,-0.037947945,-0.054518327,0.014122219,-0.08583265,0.05361775,0.02102704,0.0136611285,-0.007414932,0.039036755,0.009558079,-0.019144345,0.009278646,0.037473172,-0.007313087,-0.0099342,-0.010578034,0.0386868,-0.057585556,0.003050623,-0.04910784,0.017189236,-0.05161471,-0.10582107,0.02451317,0.043431174,-0.009326952,0.019299285,0.004953201,0.02636778,-0.03828612,-0.049975444,-0.029548813,0.05684437,-0.041254777,0.0500402,0.005163804,-0.039471876,-0.024295216,-0.06650517,-0.0066454345,-0.008557944,-0.06687286,-0.0015975725,0.0044735195,-0.0013205761,7.542784e-05,0.04423058,0.003929223,-0.04023829,-0.025187656,-0.09221005,-0.07756214,-0.03730481,-0.052331287,0.053691942,0.052114695,-0.1205937,-0.021001462,-0.038588908,0.1119529,-0.0022227287 +3.2.1.192,"Ginsenosidases catalyse the hydrolysis of glycosyl moieties attached to the C-3, C-6 or C-20 position of ginsenosides. They are specific with respect to the nature of the glycosidic linkage, the position and the order in which the linkages are cleaved. Ginsenoside Rb1 beta-glucosidase specifically and sequentially hydrolyses the 20-[beta-D-glucopyranosyl-(1->6)-beta-D glucopyranosyloxy] residues attached to position 20 by first hydrolysing the (1->6)-glucosidic bond to generate ginsenoside Rd as an intermediate, followed by hydrolysis of the remaining 20-O-beta-D-glucosidic bond. ",384,1.0,-0.043742727,-0.07810891,-0.07538978,0.04718887,-0.015298851,0.021170467,-0.049615476,0.03398341,0.07970221,0.027485378,-0.02832133,0.14361043,-0.016954938,0.061972003,-0.08496083,0.010072735,-0.030106843,0.084619954,-0.09173329,0.03768469,0.08432725,-0.062198043,-0.007326841,0.020176267,0.12059649,0.0030714406,0.044666998,-0.07365878,0.010213848,0.015911067,-0.026484763,-0.0408594,0.026069751,-0.05763207,0.019468687,0.011870367,-0.047390074,-0.069455646,0.09543774,-0.027322661,0.022903193,0.03776179,0.026271032,-0.043625083,-0.013482216,-0.04554946,-0.020199286,0.10135698,0.059832677,0.04589435,0.049321078,-0.064119324,-0.06582381,-0.023806714,0.0051939855,0.016566653,-0.07481861,0.012906223,0.10355141,0.14983757,0.079817936,0.026369303,-0.071268715,0.041357376,-0.08852993,-0.06821309,0.021292374,0.06836494,-0.02336501,-0.010113565,-0.022492602,-0.04112754,-3.5130186e-05,-0.047433928,0.06125496,-0.011725607,0.010336791,0.009901683,-0.010843829,-0.031227281,0.027503138,-0.0012949489,0.090619884,0.08880991,-0.00085821666,0.03395875,0.016474765,0.07501918,0.03807947,-0.02364055,-0.014029184,-0.06871451,-0.020565953,-0.0024178938,0.061012648,-0.0072094505,0.06377408,0.030967323,-0.012750559,-0.031772297,-0.027385825,0.050776448,0.038126826,-0.069322355,0.019603617,0.091034554,-0.07191529,0.087885134,0.09425845,0.008512291,-0.034110103,0.08961153,0.024125801,0.010983952,-0.08229668,0.0020188647,-0.025684237,-0.008157284,0.0016904001,-0.018817138,0.059278663,-0.034875475,-0.0033615213,-0.021469008,-0.09268001,0.038872182,0.057450376,2.9672506e-33,0.016318683,0.01813579,0.038161892,-0.0003683827,-0.016625628,0.034197316,-0.044189114,-0.08995941,-0.033960633,0.07084078,-0.06586038,-0.005174862,-0.026392777,0.050421298,-0.03941417,0.050778586,-0.0035872173,-0.033697765,-0.00026695727,0.027194494,0.027030664,0.09996876,-0.107545346,-0.0097305365,0.016175676,0.046179842,-0.034976006,0.058198232,0.037759937,-0.020042296,-0.04103469,0.0330497,-0.057441693,-0.018435206,0.023907388,0.0376868,-0.030058715,-0.075262085,0.05245005,-0.026133113,0.0010951152,0.012660187,-0.09039849,-0.033754926,0.027753536,-0.03904501,-0.03122079,0.033588234,-0.032769524,0.11858364,-0.046369877,0.066550136,0.04297121,0.082477696,-0.038850978,-0.06994559,-0.0031595337,-0.04265872,0.025601167,0.06239406,0.0028445516,-0.008218744,-0.0012724604,-0.023003876,0.035739806,0.06013103,-0.11590264,0.06453115,-0.02758386,0.015096388,-0.07444359,0.0050316737,-0.045019306,-0.0044435696,-0.0028495763,-0.08524215,0.06858937,0.04569054,-0.005185872,0.017067943,0.0093322955,0.04295861,-0.017059192,0.008621475,-0.034521908,0.040225085,-0.04491986,-0.091300674,-0.04132149,0.006408426,-0.035748925,-0.040081944,-0.031430233,0.07465339,-0.030732032,-4.707608e-33,0.13028963,-0.11722594,0.08572893,-0.065471984,-0.03338477,-0.031170754,0.0008756499,-0.13064772,-0.03929143,-0.04596363,-0.02721279,0.031930156,-0.052423075,0.028057419,-0.079376325,-0.0064363624,-0.009329865,0.036745,-0.082476355,0.061562046,0.039241225,0.09084243,0.013189671,0.016227158,0.016725482,-0.04663301,0.017176567,-0.034745205,0.03241261,0.10430192,0.050556004,-0.022721682,-0.022800935,-0.032167435,0.0030744905,0.0704912,-0.04154261,-0.04022702,0.03928236,-0.04539213,0.019500261,0.050093375,-0.012786511,0.00619539,0.12415368,0.086603366,-0.10072984,0.019095616,-0.09806247,-0.0385246,-0.022122774,0.04505093,-0.03626944,0.08189983,0.034571167,-0.058162652,0.03478637,-0.018362375,0.03039688,-0.050285745,-0.03341876,-0.0020081631,0.013841121,-0.06468897,0.02270985,0.027186211,-0.061529934,0.08929301,0.03631647,0.010931047,-0.012755671,-0.07170331,0.03853711,0.031567704,0.027167197,-0.0298027,-0.061882168,-0.07029819,-0.037508853,-0.03617159,0.016766502,0.05425468,-0.014880156,0.005034006,0.0030476495,-0.021475816,0.03664459,0.07461686,0.015481832,0.059224598,-0.029288944,0.014053006,0.03177094,0.06601064,0.11439892,-4.0324682e-08,0.03144651,0.0048766998,0.011153866,-0.050182648,-0.08700229,0.027997125,-0.08326394,0.025749924,-0.051561534,-0.005892771,0.02029592,0.04728878,-0.02539238,-0.042401657,-0.03450886,0.029617948,-0.03494069,-0.010357324,0.025493247,0.053547304,-0.082969695,0.010037012,-0.0035642309,0.053518236,-0.017787341,-0.1360243,0.046706207,0.05045769,-0.039092395,0.04446895,0.040125538,0.033776414,-0.062823206,-0.016099492,-0.0013206598,0.046484493,-0.04653849,0.07113922,0.0023313614,-0.045949914,-0.022278344,-0.08341574,-0.041857477,0.024569916,-0.032300964,-0.029956445,0.021384137,-0.012509692,-0.029825196,0.04845272,-0.018346742,-0.03525264,-0.03811827,-0.12188716,-0.06338783,-0.011957634,-0.03592163,0.027745223,0.020130895,-0.07768276,-0.051551227,-0.016683167,0.0578055,-0.031923838 +3.2.1.193,"Ginsenosidase type I is slightly activated by Mg2+ or Ca2+ [1]. The enzyme hydrolyses the 3-O-beta-D-(1->2)-glucosidic bond, the 3-O-beta-D-glucopyranosyl bond and the 20-O-beta-D-(1->6)-glycosidic bond of protopanaxadiol-type ginsenosides. It usually leaves a single glucosyl residue attached at position 20 and one or no glucosyl residues at position 3. Starting with a ginsenoside that is glycosylated at both positions (e.g. ginsenoside Rb1, Rb2, Rb3, Rc or Rd), the most common products are ginsenoside F2 and ginsenoside C-K, with low amounts of ginsenoside Rh2.",384,1.0,-0.032298747,-0.11166988,-0.08854295,-0.006822772,0.005491257,-0.040439416,0.0035899237,0.0906253,0.10259365,0.07641818,0.0029710676,0.105350725,0.002641332,0.10201803,-0.042136006,0.0053358176,-0.0014803251,0.07437113,-0.041787874,-0.0013853372,0.13240498,-0.028549336,0.028664976,0.018405411,0.08428477,0.029151458,0.05751796,-0.06687528,0.026578367,0.028536687,-0.06578987,0.0060892715,0.06426654,-0.07775971,0.006181456,0.012929306,-0.07660563,-0.031747557,0.04305172,-0.022297168,0.051052447,0.02319245,0.050871894,-0.03855544,-0.003689707,-0.078465216,-0.010131655,0.07744779,0.07344317,0.0713317,0.06970932,-0.044334546,-0.029087448,0.020992594,-0.0063732136,-0.033191368,-0.083004005,0.027225785,0.093607396,0.12812486,0.06251204,0.017776096,-0.06956507,0.005484913,-0.04344094,0.010487758,0.0039596693,0.06545113,0.020191578,-0.016784362,-0.0050569926,-0.014159813,0.0013026462,-0.022279559,0.07985003,-0.011758588,0.059753053,0.0015577946,0.006041383,-0.053567637,0.053797476,-0.010671352,0.0723432,0.09753213,0.0137816025,0.044724483,0.025610708,0.12244088,0.037895028,-0.013243528,0.0213728,-0.024658734,-0.011633552,0.010815101,0.08177764,0.007534215,0.029893445,0.029406723,0.0004765074,-0.011223381,-0.0181017,0.016221434,0.028086908,-0.07235155,-0.004001513,0.09869517,-0.09433727,0.013142097,0.057650004,0.026758863,0.020872548,0.053895146,-0.030742273,-0.009898368,-0.101753764,0.036743157,0.008885689,-0.03516392,-0.012932658,-0.005617256,0.018355608,-0.046926264,0.018187495,-0.044399768,-0.067609884,0.056163095,0.034424737,4.6075602e-33,-0.042931598,0.033646554,0.021244727,0.03928264,-0.008454635,0.041597724,-0.025097968,-0.077255696,-0.033594698,0.027676882,-0.07326456,0.0151817,-0.035146777,0.003312727,-0.020655628,0.008424471,-0.004636597,-0.077370934,0.021620203,0.041330215,0.067615755,0.14499973,-0.10977548,0.036732454,-0.00097232126,0.025416458,-0.0378903,-0.015069283,0.0009654387,-0.017754925,-0.028508738,-0.03218707,-0.0600256,-0.005831495,0.026729396,0.03858509,-0.041003663,-0.10555056,0.026815472,-0.04544301,-0.058006406,-0.0052379346,-0.071189575,0.002494378,0.008346104,-0.0844831,-0.07050738,0.01968292,-0.025528355,0.14665756,-0.013675608,0.09436465,0.031769194,0.035205968,-0.09623229,-0.05879503,0.0071448013,-0.041649863,0.051171258,0.020102317,-0.0017267732,-0.046741005,0.008112845,0.031688895,0.030495754,0.08058015,-0.12923975,-0.0032281873,-0.03602778,0.03893052,-0.046099257,-0.0297243,-0.08178537,-0.013087991,0.008051765,-0.050823387,0.064949304,0.096898586,-0.02438326,0.025588749,-0.016680982,-0.018741407,-0.02501212,0.042388268,-0.09568487,0.035647318,-0.05947778,-0.064618714,-0.044995356,-0.006532107,0.01691625,0.00022972724,-0.034862727,0.0884754,0.007631929,-5.3811766e-33,0.099902965,-0.09167707,0.10624632,-0.043916687,-0.048546765,0.021805784,0.01976426,-0.087742545,-0.023053924,-0.036105398,0.054801296,0.009850277,-0.031223873,0.01822339,-0.07843692,0.014544498,-0.013696808,0.07747154,-0.064296916,0.04346268,0.023857757,0.09859503,0.01279879,0.025275016,0.023024242,-0.040750038,0.008352472,-0.05468696,-0.030315127,0.1071756,0.020776236,0.019093651,-0.05533575,-0.019295845,-0.0060297786,0.028050289,0.020634277,-0.06729399,-0.026178418,0.0023163743,-0.022712741,0.07415974,0.048258353,0.06901283,0.07408523,0.04825155,-0.100291066,0.055959232,-0.070391245,-0.026142832,-0.07284657,0.04126395,-0.0330671,0.06332066,0.044932775,-0.047543537,0.057493538,-0.012671098,0.010207152,-0.013084579,-0.036134742,-0.04331565,-0.014354744,-0.04728206,0.074394405,-0.03045755,-0.040005215,0.06292712,0.023472441,0.009603671,0.052535746,-0.039916754,0.025819909,0.022860052,-0.009892326,-0.0045690327,-0.014205012,-0.0789143,-0.0010765706,-0.08563159,0.03389299,0.039602403,0.027714131,0.038645573,-0.051809307,-0.031477213,0.017633835,0.05448012,0.0305572,0.07287295,-0.03781977,0.013987317,-0.03905722,0.045153446,0.10957721,-5.2066483e-08,-0.021949394,0.012815473,-0.025289783,-0.06323716,-0.051716115,0.009476452,-0.11007467,0.039635323,-0.018225336,0.00021741937,0.0026713305,0.04535829,-0.050049745,-0.05099177,-0.004931277,0.05180325,-0.00889626,0.019553501,-0.002770149,0.029651757,-0.09132725,-0.0362854,-0.02624704,0.02317089,-0.052425448,-0.09989477,0.039865255,0.08269595,0.008041068,0.01554703,-0.0005553038,0.004489916,-0.047179345,-0.069991425,-0.054448403,0.0751338,-0.044231948,0.04122742,-0.048528574,-0.055962756,-0.018083602,-0.09403914,0.004418938,0.0034042525,-0.038890474,-0.013954251,0.04339087,0.008371197,0.00036585395,0.02745499,-0.004396812,-0.04262322,-0.029676683,-0.09545224,-0.09892254,-0.027113011,-0.0235601,0.04214667,0.07714797,-0.117716536,-0.03230911,-0.0124617675,0.055778828,-0.021725344 +3.2.1.194,"Ginsenosidase type IV catalyses the sequential hydrolysis of the 6-O-beta-D-(1->2)-glycosidic bond or the 6-O-alpha-D-(1->2)-glycosidic bond in protopanaxatriol-type ginsenosides with a disacchride attached to the C6 position, followed by the hydrolysis of the remaining 6-O-beta-D-glycosidic bond (e.g. ginsenoside Re -> ginsenoside Rg1 -> ginsenoside F1).",384,1.0,-0.017215721,-0.054274693,-0.027130099,0.030536162,-0.03573482,-0.022756718,-0.054997895,0.058691353,0.06432927,0.0828299,-0.054874044,0.13028486,-0.10275852,0.059650004,-0.09708165,-0.008378048,-0.0297157,0.09674952,-0.037450686,0.05900598,0.0657935,-0.0308744,0.039245613,0.022902219,0.14471005,0.014846358,0.05028392,-0.021362843,0.025923414,0.024032565,-0.0049327803,0.024799248,0.03662131,-0.05783944,-0.0049849013,0.0428527,-0.016936393,-0.052219294,0.07369983,-0.027491959,0.019829273,0.03635081,0.046201732,-0.04125138,0.009106291,-0.08832849,-0.0670693,0.09042707,0.09057848,0.06208485,0.062128596,-0.05539248,-0.08030618,0.014293127,-0.020008812,-0.0039420137,-0.07831297,-0.024984343,0.101606585,0.1742812,0.075747944,0.047755547,-0.04358012,0.07122062,-0.04916917,-0.045111433,0.015845846,0.10139426,-0.027741967,-0.0015297844,-0.025942732,-0.03114831,0.006738798,-0.038814418,0.07167776,-0.03231492,-0.017811425,0.0095922435,0.017705653,-0.04043919,0.04442745,0.0025491447,0.019870182,0.13059258,-0.020161858,0.034234807,0.0029479596,0.08151484,0.08678149,-0.009491363,-0.045160037,-0.020171123,0.009243409,-0.01265753,0.02912664,-0.006814163,0.043434545,0.03917132,-0.0038922925,-0.011404811,-0.0054996293,0.035956938,-0.01509932,-0.07572689,0.012054328,0.070582,-0.07089336,0.057399094,0.074733704,0.024113275,-0.009173824,0.042116154,0.013739592,-0.0078623425,-0.10095669,-0.007160023,-0.035908956,0.000514714,0.0059129107,-0.033690337,0.020791814,-0.058699556,0.021842021,-0.030551407,-0.083841495,0.027912758,0.079250045,2.3754768e-33,-0.0046289125,-0.026290342,0.05958404,0.010238687,-0.032982655,0.054897398,-0.030132998,-0.10844,-0.06198111,0.024650816,-0.094427966,0.011567732,-0.04899237,0.009283443,0.028598972,0.013456784,0.023316726,0.007762719,-0.016912885,0.035086855,0.04144073,0.11018957,-0.11865715,0.025452958,0.03715614,0.047491286,-0.011072231,0.023316704,0.008896871,-0.019616548,-0.05263585,0.026918761,-0.049037926,-0.0013649943,0.032246232,0.035782855,-0.043502875,-0.078501165,0.059843197,-0.033119936,-0.03871737,0.008374251,-0.089847274,-0.025860373,-0.0019553278,-0.030138507,-0.035183042,0.03474656,0.0007738629,0.1006329,-0.05050408,0.08236201,0.019581806,0.0779427,-0.063674904,-0.050690446,-0.0024709068,-0.015668657,0.029494839,0.0578243,-0.03753483,0.002702167,-0.0031819742,0.007964774,-0.028229374,0.045159604,-0.10285946,0.026190069,-0.040676273,0.021343444,-0.08006717,-0.020846931,-0.07401867,-0.018897105,0.005739501,-0.0683179,0.06655648,0.099583484,-0.021101316,-0.0013120198,0.016715473,0.012566201,-0.02201679,0.046794552,-0.014057706,0.0727952,-0.059502915,-0.06130095,-0.0070720967,0.029458987,0.022862146,-0.015721675,-0.07690398,0.06562807,-0.0016163547,-3.6621344e-33,0.0824812,-0.0925517,0.053352263,-0.049094547,-0.05303646,-0.010782882,-0.010745075,-0.07378591,-0.075200066,-0.08282088,-0.0029067593,0.01771609,-0.05096701,0.021654734,-0.09169382,-0.00301775,0.01562532,0.05098181,-0.052450404,0.05960535,0.033756606,0.08370293,-0.009849793,-0.005807768,0.0021906872,-0.042588856,0.04657224,-0.032439087,0.0060541313,0.0688326,0.07378291,-0.012485084,-0.045337066,-0.00915397,0.022165505,0.055034876,0.008478559,-0.053840924,-0.020005839,-0.00026488956,-0.015720338,0.056543577,0.022893174,0.03162605,0.10245215,0.039732333,-0.087884724,0.04416451,-0.05615483,0.030072074,-0.016046116,0.018192159,-0.04405577,0.07585691,0.026904648,-0.09479246,0.06978425,-0.05608154,-0.010701641,-0.042818673,-0.010860738,-0.010512501,0.03584848,-0.04997028,0.048853055,-0.0056323763,-0.052383922,0.109458156,0.010058701,-0.035345092,0.039020065,-0.06268182,0.037899308,0.00455885,0.04380035,-0.024839645,-0.02923701,-0.086383335,0.0032097658,-0.024957156,0.0008334746,0.0892449,0.016790664,0.023184404,-0.038601257,-0.03812996,0.06258161,0.07418074,-0.008872854,0.1339426,0.0055272994,0.023389857,-0.024271928,0.046001468,0.12205041,-4.2609617e-08,0.005094262,-0.025964867,0.0049536205,-0.043831475,-0.051995266,0.013548332,-0.073708594,0.034288403,-0.03608321,-0.011247888,0.020760518,0.06169078,0.023043571,-0.041289505,-0.02618119,0.041784845,-0.0033954086,-0.0047493023,-0.02467735,0.06470726,-0.070918836,-0.029478028,0.0017242371,0.03791838,-0.03385384,-0.119229324,0.025574636,0.035754137,-0.006268292,0.018947467,-0.013939832,0.027461221,-0.06564638,-0.030054262,-0.025219008,0.044447605,-0.032805208,0.04850995,-0.03632967,-0.06522455,-0.067051195,-0.089807004,-0.0074248365,0.016629616,-0.04623142,-0.016773706,0.01738232,0.0072137224,-0.01967714,0.08375873,-0.037087597,-0.029483123,-0.020312244,-0.1326378,-0.068580516,-0.040619843,-0.025248235,0.06399507,0.004194942,-0.09991051,-0.039082967,-0.03802324,0.09350807,-0.03006576 +3.2.1.195,"The 20-O-multi-glycoside ginsenosidase catalyses the hydrolysis of the 20-O-alpha-(1->6)-glycosidic bond and the 20-O-beta-(1->6)-glycosidic bond of protopanaxadiol-type ginsenosides. The enzyme usually leaves a single glucosyl residue attached at position 20, although it can cleave the remaining glucosyl residue with a lower efficiency. Starting with a ginsenoside that is glycosylated at positions 3 and 20, such as ginsenosides Rb1, Rb2, Rb3 and Rc, the most common product is ginsenoside Rd, with a low amount of ginsenoside Rg3 also formed.",384,0.99999994,-0.014625804,-0.0860614,-0.12281162,0.0016561465,0.033857424,-0.0128402505,-0.022607435,0.1036826,0.09245667,0.013602012,-0.012143292,0.1401271,-0.03023408,0.081983805,-0.06419559,0.008498187,-0.010621822,0.08180699,-0.06410731,-0.0020767252,0.107688814,-0.05455991,0.046473663,0.013020816,0.1048528,0.0051974547,0.05215663,-0.08482694,0.031023439,0.01636464,-0.002373578,-0.032666165,0.061336346,-0.07259491,0.0020134333,0.008730424,-0.07255646,-0.05048788,0.05911521,0.00030703406,0.021658998,0.041436505,0.029291954,-0.04799899,-0.0016593171,-0.072194025,-0.03547051,0.06977801,0.07235056,0.060708538,0.04974987,-0.07015861,-0.07100537,-0.0037310433,0.013982934,-0.03357032,-0.08850201,-0.0026481852,0.07373496,0.12675126,0.075286455,0.013684948,-0.06494139,0.021707194,-0.07981277,0.002674069,0.033169765,0.069775134,-0.025097122,0.02627911,-0.03684545,-0.023683034,-0.024126366,-0.024462627,0.034405764,0.02646833,0.044569828,0.010090754,0.015221548,-0.038942244,0.03802128,-0.0004245004,0.05702778,0.12932326,-0.007938082,0.0640027,0.018708427,0.09952994,0.06812152,-0.017683698,-0.04861498,-0.019826503,0.01639547,0.004788521,0.04425854,0.004747557,0.043482017,0.037505936,-0.005717537,-0.033995505,-0.03097104,0.046730064,0.048579972,-0.0742305,-0.017791351,0.09862724,-0.07524287,0.042727146,0.10908077,0.03503961,0.006305846,0.05477745,-0.022233244,-0.023955835,-0.08682342,-0.0103437975,0.005325477,-0.020293262,-0.007637839,0.008596807,0.020931937,-0.04553218,0.037229586,-0.022609571,-0.061646104,0.05252479,0.0491539,3.1426838e-33,-0.02029394,0.031987783,-0.006139031,0.028073357,-0.012658585,0.06908414,-0.025249232,-0.06155918,-0.047810677,0.040566698,-0.09226085,0.023760594,-0.026096903,-0.00073932717,-0.0039876904,0.006878116,0.004189289,-0.028351057,-0.020461777,0.04728837,0.050059438,0.13423324,-0.11278405,0.048011653,0.010157774,-0.00085577666,-0.017059945,0.015133309,0.0073854425,-0.040350396,-0.011856334,0.0014296742,-0.08555688,0.012596802,0.011513008,0.015084714,-0.08181239,-0.072474405,0.06134167,-0.014199121,-0.044029567,0.028436381,-0.05392315,-0.014386209,0.03195895,-0.06749392,-0.038459584,0.03212334,-0.018679257,0.12207985,-0.06259073,0.11804985,0.0366859,0.07038309,-0.08441914,-0.059318013,-0.0024985375,-0.007456699,0.056787167,0.047994163,-0.021345692,0.007982727,0.016087517,0.0082045505,-0.00024654684,0.091560565,-0.10430197,0.00983479,-0.026275858,0.045706805,-0.020570058,-0.0107880775,-0.05926423,-0.020705609,0.0074134897,-0.07763406,0.08415531,0.07809457,-0.020708201,0.021663535,-0.01780316,0.009956259,0.0005354373,0.030150509,-0.08762733,0.04165937,-0.056722928,-0.07424332,-0.04384578,0.051984265,-0.0094691785,-0.058539517,-0.054840107,0.055796802,-0.03936062,-2.8764003e-33,0.11942953,-0.09815325,0.07542831,-0.0470661,-0.027077157,0.0012369611,0.0062350417,-0.065115295,-0.051696885,-0.034236245,0.032870267,0.02439994,0.015030549,0.037735794,-0.06855222,0.0026839746,0.004912984,0.087912634,-0.049336422,0.030084815,0.032198638,0.113355994,0.012574505,0.030262517,0.03515361,-0.022086423,0.0038539094,-0.076952256,-0.028999742,0.058070026,0.04915626,-0.00016713394,-0.018777614,-0.020833839,0.012367134,0.040814705,0.04011514,-0.055171154,-0.014725541,-0.039215643,-0.02162564,0.07160314,0.048130706,0.049921706,0.06789288,0.048382908,-0.1428253,0.043962557,-0.07083358,-0.0015795303,-0.057577524,0.03250977,-0.042337444,0.058647092,0.05046249,-0.06520106,0.04870239,-0.005722784,0.00021009907,-0.019786565,-0.015461065,-0.04032205,-0.00057979074,-0.013599782,0.06421077,0.011645988,-0.06684488,0.07517708,0.025370648,0.011690784,0.034490224,-0.03446434,0.040889524,0.009534096,0.01723015,0.014231506,-0.00792784,-0.084992856,-0.0017346657,-0.070534274,0.010149202,0.0039273826,0.03231035,0.04301777,-0.058738932,-0.05879887,0.026082465,0.072276786,0.011435351,0.107859045,-0.020686695,0.022864765,-0.009404567,0.06278939,0.1295183,-4.1006604e-08,0.01384264,-4.8491638e-05,-0.0040781857,-0.048841815,-0.055633537,0.009920511,-0.08517221,0.016468896,-0.028207418,0.0040542306,0.018710237,0.045528572,-0.05507502,-0.054273937,-0.0315595,0.03066871,-0.042511344,0.017726129,-0.0014805269,0.05942311,-0.09738273,0.02614769,-0.021765513,0.033493936,-0.025738437,-0.08677318,0.058779266,0.06329292,-0.010979227,0.00061193254,0.014725912,0.014302265,-0.027481785,-0.03186762,-0.028909279,0.04286627,-0.035955317,0.09043663,-0.028077789,-0.018864138,-0.056931004,-0.1311063,-0.0004152256,0.019542804,-0.047579437,-0.03804855,0.009275619,-0.021434383,-0.023699963,0.003160214,-0.013766627,-0.039695274,-0.021314401,-0.10280765,-0.08777899,-0.046132393,-0.019830761,0.018242702,0.0590198,-0.09585745,-0.061927833,-0.0042958707,0.07933134,-0.00010965511 +3.2.2.30,"The enzyme, found in several bacterial species, catalyses a step in a modified futalosine pathway for menaquinone biosynthesis. While the enzyme from some organisms also has the activity of EC 3.2.2.9, adenosylhomocysteine nucleosidase, the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine [7].",384,1.0,-0.038183674,-0.0162808,-0.12819089,-0.053606465,-0.028701525,0.014195903,-0.06631238,-0.022275172,0.056558277,0.043247506,0.05541685,-0.02743027,-0.07230807,0.0037643793,-0.02044045,0.07181279,-0.12875116,-0.03809364,0.025414297,-0.05486152,0.08013582,0.042075064,-0.023824083,-0.048299782,0.0028014001,0.01396537,0.024075415,0.048280507,-0.03096955,-0.03779431,-0.0066788974,-0.027472217,0.06176414,-0.037754353,0.051764056,0.11377226,-0.12012381,-0.08161536,0.12667607,0.06400405,-0.019306755,-0.027337141,-0.013904247,-0.046945937,-0.037388384,-0.014643811,0.04128083,0.040421877,0.09883101,0.027008586,0.024625732,-0.032057464,-0.006825414,0.0030011768,0.06623849,-0.008731166,-0.06444405,-0.01086237,-0.0033284272,0.009591096,0.043428857,0.024336237,0.038333483,0.04054518,0.03022125,-0.09095177,-0.056269545,-0.049518127,0.04334721,-0.03266198,-0.017921865,-0.008452959,-0.039233092,0.0426343,-0.01213698,0.031191872,-0.051961508,-0.08045802,0.005714873,-0.0048976494,-0.011128128,0.012440316,0.055842727,0.09174463,0.09001885,-0.008365298,0.019401103,-0.017387172,-0.02594616,0.08275585,0.07778825,-0.021449478,0.036623236,-0.053069234,0.009940523,0.013930499,0.015084053,0.060275625,-0.031645127,-0.03612964,-0.0078250095,0.0038063794,-0.09247837,-0.068347335,0.04438858,0.040748138,0.023640536,0.07475436,-0.0038349659,-0.014778058,-0.084803596,-0.007294252,0.029992227,-0.0018769025,0.026949588,0.066659965,0.08210054,-0.024621464,-0.016694358,-0.003318418,-0.00017208661,-0.0056879646,0.08396727,0.07533504,-0.028555525,0.06412095,-0.074684866,3.489622e-33,-0.004556346,0.0222799,0.013808877,-0.01248302,0.023973873,-0.0053479206,-0.017805787,-0.024614127,-0.0035098512,-0.055398785,-0.09827952,0.002860819,0.049555477,-0.046450082,0.0023183955,-0.0068487064,0.0031465178,-0.013254977,0.038169667,0.013532704,0.025743242,0.014652942,0.02668946,-0.084196836,0.0054236404,0.031207621,-0.010206047,0.049279444,0.061140817,-0.0045342296,-0.076127514,-0.042687833,-0.10042641,-0.06367782,0.019452583,0.0062663658,-0.11211436,-0.0386398,-0.08127617,0.100143395,-0.0074510677,-0.01774127,-0.061574947,-0.046023827,0.02331043,0.061124384,-0.020333152,0.081871055,0.072124556,0.0026819096,0.02563703,0.034800675,0.10184177,-0.095966935,-0.02304133,-0.051405083,0.055031907,-0.0034923144,0.031302232,0.10567242,0.030989423,0.018955676,0.0039540846,0.007256704,-0.04841948,-0.045539718,-0.0026946869,-0.032555573,-0.008129785,0.042735994,-0.060735714,0.0073587988,0.07392649,-0.0044268663,0.06443607,-0.008921283,-0.1019631,-0.071357474,0.0031111634,-0.07750164,0.019507648,-0.059209514,0.039361745,-0.038518876,0.0067986725,-0.009647111,-0.078973256,-0.032580465,-0.009018611,0.039663054,0.021781951,-0.08342893,-0.08307233,0.018905785,0.06074595,-4.496442e-33,0.0048891767,-0.08047021,0.009591907,-0.12479893,-0.014595545,0.09272032,0.0124034695,-0.02377044,0.014008066,0.022651756,0.06929375,-0.032462087,0.041446883,-0.047790676,0.036438484,0.0026652669,-0.031329982,0.059809756,0.01477241,-0.028945334,-0.0037265536,0.040417463,0.0103350375,-0.006290738,-0.0027094448,0.022204852,0.012612226,-0.010031228,0.081659816,0.017441247,-0.058266677,0.00478637,-0.053742405,0.04023726,0.028367076,0.025392246,-0.026350468,0.012826561,0.09699569,0.0014039167,0.049034663,0.04289898,0.049470436,0.0767405,0.006241457,0.1075551,-0.04162889,0.033358753,-0.058305036,-0.018848222,0.044938456,-0.013849335,-0.026515447,0.03949975,0.055497807,0.05578455,0.013035657,-0.021786673,0.036940683,0.019723454,-0.10339015,-0.05484624,0.0075980173,-0.02237145,-0.004063463,0.018832095,-0.08670136,0.097335294,-0.026118338,0.013018354,0.07742502,-0.029496519,-0.03179856,0.0008465693,-0.039505273,-0.010874085,-0.008662836,-0.038240008,0.06963216,0.0048608053,-0.014233917,0.0054847994,0.016678857,-0.0021924227,-0.026262604,-0.07485335,0.10054022,0.04860789,-0.07437781,0.08744436,0.018186463,-0.0013477633,-0.06407991,0.0510601,0.019925892,-3.6746453e-08,-0.014061125,-0.1003068,0.029395923,-0.043219693,0.12844387,0.04598527,-0.04894159,0.07156344,0.05312045,-0.033721574,-0.02285696,0.056590773,0.043481622,0.027542245,-0.013962164,0.06729034,-0.05569837,-0.011890152,0.048080426,-0.043264728,-0.04374611,0.0007284258,-0.15039188,0.036120288,0.0050231395,-0.00748795,0.015970664,0.058006953,-0.04581933,-0.025087416,-6.7439316e-05,0.014282192,-0.06929513,-0.04053994,-0.080264114,-4.625358e-07,-0.034256604,-0.05999985,-0.02860782,-0.02041921,0.02475024,-0.04506015,0.0019737573,-0.017982997,0.008407371,0.02854119,-0.0041730874,0.04669122,-0.05834125,0.013105283,0.033586405,-0.062496282,0.045749012,0.0043219323,-0.06451274,-0.054143637,-0.025366072,-0.109114066,-0.049379945,-0.046675105,-0.020611957,0.02744703,0.27448106,0.00014066866 +3.5.1.116,"This plant enzyme is involved in the degradation of ureidoglycolate, an intermediate of purine degradation. Not to be confused with EC 4.3.2.3, ureidoglycolate lyase, which releases urea rather than ammonia.",384,0.99999994,-0.015730208,0.029052587,0.025836237,-0.0014784841,0.08005142,0.08907444,-0.014801088,0.00906188,-0.015236418,0.011406884,-0.018397648,-0.0136231035,-0.058084495,-0.01031534,-0.10339784,0.021257801,-0.07797061,0.0027988625,-0.018646276,-0.048736647,0.11521687,0.011806419,-0.07590186,-0.042893253,0.051252834,-0.015782334,0.027091967,-0.05908704,-0.005007098,-0.11128248,-0.033769965,-0.019436851,0.036224715,-0.047806494,-0.0025956444,0.10669383,-0.032432035,-0.103846185,0.019894563,0.052848727,0.04985754,-0.0072811856,-0.030840067,-0.071478985,-0.04364828,0.045761812,-0.005091199,-0.010797567,-0.008789355,-0.08839134,-0.0508576,-0.039185025,0.050003417,0.00393719,0.0021068787,0.0014489903,-0.031092746,0.016962033,-0.030108547,0.030832052,0.05938891,0.061512675,0.04472983,-0.056967217,0.042788588,-0.06347163,-0.020493768,-0.020078316,0.029932665,-0.042548977,-0.06532445,-0.05035382,-0.044004913,-0.01011318,-0.0077060275,0.0151603855,-0.05715714,-0.035550736,0.031525694,-0.022881025,0.070630275,0.013899071,0.09639672,-0.0012594193,0.0054753083,-0.01615854,0.009034202,-0.05555369,0.022009928,-0.038260587,0.068447925,-0.010481816,0.027510481,0.031149242,0.013090271,0.04172383,0.049666367,-0.0281953,0.03059081,-0.036317732,-0.042678066,0.086095974,-0.06424585,-0.14722158,0.0029639108,0.024337023,0.014619408,0.058484703,0.091693215,0.026902176,-0.058491897,-0.0321004,-0.023911634,0.0266736,-0.050789643,0.052326526,0.046670612,-0.01514979,-0.0979044,0.026779825,0.016689567,-0.0073226793,-0.031535823,0.07147542,-0.036477804,0.016782308,-0.05662317,1.0329056e-33,0.064264745,-0.004045378,-0.05859166,-0.03484342,0.023893083,-0.018397562,-0.03679086,-0.040163744,0.029857049,-0.1312418,-0.100109406,-0.033873342,-0.07907899,-0.00761167,-0.052620642,0.007424457,-0.03950571,0.034530114,0.12831299,0.009280293,0.056078006,0.04836082,-0.081679076,-0.027713118,0.015926441,0.03276935,0.052502096,-0.020614656,-0.015817298,-0.028472472,0.056907915,-0.054023486,-0.10931378,-0.021911222,0.019997142,-0.04186272,-0.039252568,-0.031889893,-0.06792507,0.034561247,-0.011062743,0.04650972,0.05002242,-0.048616514,0.0499365,-0.03252902,-0.048288126,0.0568256,0.04520132,0.08518726,-0.02479545,-0.022929832,0.08909102,-0.00380027,-0.044812895,-0.043750256,0.013431936,-0.03722548,0.019669974,0.07004157,0.024099583,0.08614254,-0.019981515,0.0063565364,0.021340163,-0.0150956325,-0.07773812,-0.015594726,0.0437304,0.048652947,-0.10305752,-0.06378831,0.052312996,-0.03879041,-0.0014841524,-0.14409633,-0.10108445,0.030305004,0.0007631588,-0.036898572,-0.009352416,-0.053926513,0.02221521,0.02454798,-0.019020302,-0.02132809,0.0075791096,0.021370731,-0.0040948046,0.019423403,0.06191822,-0.02823858,-0.023211313,0.06805141,0.03696764,-2.1224024e-33,0.15693642,-0.065738454,0.08414987,0.028079366,-0.060834363,0.05464105,-0.02413647,0.06570452,0.03084287,0.06095908,0.071434386,-0.017237773,0.058691934,-0.023534311,0.015755223,0.048400324,0.0368473,0.030360011,-0.06056869,-0.039254177,-0.08624926,0.048176244,-0.017202554,0.0276425,0.03573751,-0.0012807581,0.05788119,0.0022635942,0.02867756,-0.03353042,-0.003491987,-0.028731061,-0.066236034,-0.03339075,-0.060629696,-0.011148474,-0.029084835,-0.008551151,-0.021249378,-0.023708697,0.08254156,-0.014128001,-0.009637587,0.06921225,0.046781827,0.07997991,-0.08997042,0.040322956,0.044995427,-0.026378931,0.06098165,-0.028706905,0.025335455,0.04325665,-0.015391495,0.012453159,0.0018644184,0.055450417,-0.089231946,0.057329364,0.017760422,-0.019369878,0.0349025,0.022449994,0.0059741023,0.018721296,-0.060742505,0.06498629,0.06839244,0.0075568235,0.10286409,0.0013393604,0.06129115,0.024953926,-0.006737921,-0.009926577,-0.045951027,-0.04677319,0.0064978455,-0.07401009,0.022848105,-0.013051482,-0.033336837,-0.067438014,0.025913808,-0.044142824,0.040032987,0.1194252,0.0144735165,0.020876547,0.008169134,-0.059884183,-0.08639247,0.048065916,0.055076018,-3.319746e-08,0.04479068,-0.07247862,-0.0066408687,-0.039995637,-0.009627941,-0.022494461,0.0591775,0.10301649,0.054421958,0.011690098,-0.018420646,0.05163535,0.00519408,0.0016645866,0.12107492,0.025834259,0.020371873,0.085480645,0.0028201991,0.0702742,-0.101818696,-0.061514035,-0.08721103,0.05952664,0.04684525,-0.024770841,0.11741555,0.05325323,-0.056011815,-0.044610996,0.09307025,0.0700909,0.027016668,0.03884478,-0.068747066,0.0771549,0.029611398,-0.0595315,-0.036790557,-0.0063877,-0.07120933,-0.003269854,-0.043826643,-0.06498788,0.017072467,-0.012664773,0.0387189,0.0019395944,0.0096779205,-0.012055612,-0.0009561712,-0.05100647,-0.00966529,-0.08805836,-0.04380398,-0.0061763013,0.013614451,-0.07320799,0.028727612,-0.050403796,0.067044325,0.0031411222,0.17847535,0.010631366 +3.5.4.40,"The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.",384,1.0,-0.036374237,-0.00533791,-0.15641314,0.0013402831,-0.019513471,0.021820175,-0.09373021,-0.009748817,0.07885712,0.018641893,0.023650894,-0.075554274,-0.090793625,0.017597493,-0.0328256,0.02298524,-0.11597564,-0.0042005046,0.05042183,-0.026620518,0.10464261,0.027761038,-0.019610927,-0.10594998,0.01961221,0.00762793,-0.012553173,0.05281027,-0.008717704,-0.019743849,0.015747013,-0.003456542,0.08784059,-0.052497733,0.04750175,0.0945993,-0.03940232,-0.07293196,0.120428585,0.028633097,-0.02849372,-0.017463194,0.0107001215,0.016741974,0.03481543,0.035610955,0.0142209735,0.011060472,0.07626992,0.065771185,-0.0466045,-0.010718983,-0.03609923,0.026629357,0.08702053,0.0018422512,0.008005069,-0.02744991,-0.005408898,-0.004675853,0.043569382,-0.0010766145,-0.019628422,0.031015975,0.0047264956,-0.046387043,-0.067524716,-0.05652936,0.010256547,-0.004765632,0.03318678,-0.048236553,-8.465253e-06,0.015462485,-0.015800675,0.06826128,-0.01760266,-0.008641864,0.02567767,-0.0051145954,0.030138575,0.048034176,-0.0068979235,0.13460785,0.040834066,-0.008139715,-0.019329447,-0.035171222,-0.00053376483,0.1074292,0.016423665,-0.01740466,0.003090491,-0.07170386,0.025935069,0.0015315181,-0.019523993,0.07213108,0.001070184,-0.06671288,-0.00842378,-0.024018623,-0.04267254,-0.08304051,-0.037456658,0.021205928,0.019359406,0.09824562,0.050896917,-0.025252424,-0.10622729,0.053400367,0.021785047,-0.03198279,0.039754618,0.05880549,0.06382148,-0.024912044,-0.044583317,0.03674526,-0.03370153,0.019204408,0.05883553,0.096007325,-0.007792356,-0.0076194364,-0.083479464,-7.6218787e-34,0.04165163,0.029134167,-0.0041731037,-0.026088145,0.03391657,-0.0257183,0.011398113,-0.098882146,-0.06792482,-0.039611388,-0.08836007,-0.040287253,-0.03775201,-0.009585722,-0.017076932,0.0042150654,0.01795154,-0.042262044,0.058038536,-0.045983568,0.001148322,0.013456886,0.0023569504,-0.09464158,0.03801537,0.033719182,-0.011454224,0.03978539,0.024761649,-0.0051341504,-0.054498684,-0.052515462,-0.098273315,-0.050212882,0.04356936,-0.0063872975,-0.05393636,-0.05180989,-0.06780367,0.06072089,0.03509709,0.035006467,-0.04984228,-0.00078343216,0.06562416,0.023450458,-0.06528905,0.09951232,0.12088764,-0.00032731032,0.008388426,0.014453836,0.13356186,-0.060787126,-0.07333108,-0.020562064,0.018000457,0.041237213,-0.031069206,0.08206476,-0.009480855,0.022481453,0.007861,0.07018384,0.0050981124,0.015067043,-0.021326734,-0.0347667,0.04390994,0.088150315,-0.051660214,-0.023982745,0.036596227,-0.02148927,0.050275885,-0.03281455,-0.106406115,-0.05390991,0.022657774,-0.08441611,0.007396353,-0.100081705,-0.04974685,-0.024264023,-0.027510822,0.013875245,-0.041435413,-0.06913727,-0.006501613,0.022211408,0.05490657,-0.11430515,-0.043736596,0.038616974,0.044101294,-1.707961e-33,-0.01542141,-0.08676106,0.023897074,-0.07963595,-0.08448392,0.06366891,-0.03433283,-0.012857174,0.016001059,0.07489076,0.027991174,-0.05903932,0.059020612,-0.0462325,-0.072554514,0.0018481731,0.019113518,0.06601565,0.016543543,-0.027447859,0.017265767,0.052187864,0.06662493,-0.035312835,-0.0068926867,0.070771545,-0.006486853,0.04577496,0.026371233,0.06717882,-0.023347536,0.058772273,-0.09471731,-0.08719771,0.03660082,-0.008120916,-0.02976782,0.040168323,0.11824656,-0.012270355,0.046791673,0.06381062,0.036154225,0.056865104,0.04939143,0.08331877,-0.039154686,0.06853987,-0.064209744,-0.041186944,-0.021592658,-0.007822191,-0.052291747,0.046528913,0.021699544,0.038015418,0.017437171,-0.038645282,0.024650857,-0.018600916,-0.111692384,-0.067181334,0.025292154,-0.033796873,0.037003554,0.07695198,0.015824422,0.07447701,0.04888107,0.011173063,0.08506431,-0.017036287,0.019607933,0.06652541,-0.058999017,0.034986615,-0.03967869,-0.058261044,0.04017732,0.03518037,-0.023497157,0.0058888113,0.0101888925,-0.0055839745,-0.06490255,-0.1179797,0.07120262,0.07971842,-0.046266586,0.08107194,-0.011154692,0.0040809857,-0.07248692,0.022625454,-0.009268138,-2.4795e-08,0.017203385,-0.055374883,0.04684519,-0.020862447,0.06764177,0.016695566,-0.08750664,0.07162298,0.07489777,-0.01019552,-0.072624676,0.057320476,0.009882269,-0.010635802,0.0016915188,0.053453494,-0.0021566548,-0.033555157,0.015224335,-0.06162863,-0.047008008,0.0069484217,-0.083262354,0.047181435,0.006577375,-0.06278926,-0.01829299,0.043385852,-0.010476297,0.0020891866,-0.01887457,0.04558566,-0.036145516,-0.02979735,-0.10448845,0.046950236,-0.037607983,-0.06748731,-0.009383213,-0.04706762,0.013298197,-0.034156997,0.014765757,0.02351465,0.002285096,0.019124102,0.0120673,0.083128035,-0.035556152,-0.033498634,0.019980982,-0.036350187,0.01499342,0.0042919065,-0.10945416,-0.0024530524,-0.041775785,-0.039906297,0.011446246,-0.05388059,-0.045855854,0.010842565,0.18462971,-0.05821953 +3.5.99.10,"This enzyme, which has been found in all species and tissues examined, catalyses the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19, threonine ammonia-lyase and EC 4.3.1.17, L-serine ammonia-lyase. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates.",384,1.0,-0.02546309,-0.049021617,0.0050247354,-0.056632604,0.11839183,0.0008767505,-0.013905378,0.026422907,0.01772214,0.07635541,-0.008675088,-0.002918128,-0.069472805,0.062761076,-0.06273939,0.08006656,-0.09866292,-0.038219646,-0.0197021,-0.05738434,0.061386466,0.019794224,-0.0687144,0.016002547,0.047785394,0.021918634,0.06456692,0.014520859,-0.06975051,-0.10731849,-0.07645789,-0.032856636,0.043715075,-0.09293767,0.0017969557,0.0839909,-0.12027199,-0.053689335,0.015773235,-0.01890106,0.037711643,-0.046822276,-0.10185294,-0.10460789,-0.04198567,-0.018442048,0.03267273,0.019215364,0.04168955,0.015199287,-0.07142853,-0.016864723,0.0050353296,-0.0003887482,-0.008386853,-0.05591261,-0.048620597,0.035481114,-0.057337247,0.003973619,0.046073407,0.04306252,0.015612873,-0.055390134,0.012673408,-0.02947457,0.05534345,-0.047713194,0.022571748,-0.038097803,-0.029732356,-0.12583119,0.05028477,-0.043848217,-0.019997437,0.013948525,-0.00812676,-0.027435765,0.027534721,0.012916346,0.0227373,-0.008553926,0.117569655,0.006807459,0.054787956,-0.0079511,-0.0382949,0.001241767,0.083258495,-0.0010001936,0.040979926,0.0060747326,0.010311582,0.053280752,0.027666481,0.03049794,0.00840601,0.03621751,0.013426986,-0.044237573,0.01694123,0.055535834,-0.11022252,-0.064356215,0.00274853,0.0041233334,0.07706074,0.054566313,0.000642762,-0.045657586,-0.045615397,-0.033872575,0.001560493,0.08115164,-0.0062482017,0.097841755,0.08004223,-0.011986716,-0.06919757,-0.020299252,0.047349878,-0.015973065,0.10794442,0.11810385,-0.036778625,0.0781995,-0.09235251,1.2865899e-33,0.03920345,0.01826339,0.041782025,-0.022187276,0.020910397,-0.029386103,-0.08547385,0.0700157,0.01718622,-0.09119571,-0.060675167,-0.011943082,0.04899187,-0.031076293,-0.059051495,-0.05812307,-0.021870924,-0.005806874,0.083493896,0.024220807,0.028077628,0.03149504,-0.06200036,0.032098055,-0.06383653,0.082164414,0.024014398,0.038094237,0.043003805,-0.012588535,0.0043419325,-0.18616754,-0.062970586,0.009776592,0.0053872387,-0.0016731194,-0.10853927,0.034509085,-0.033465143,0.10530017,-0.005907648,-0.003043905,0.01998893,-0.06553669,0.025380153,-0.0044907485,-0.06940759,0.09730681,0.013559484,-0.00018503335,0.024188709,-0.02738674,0.093638696,-0.05973976,-0.0842626,-0.023067722,-0.01170723,0.00032376507,-0.005331905,0.10761681,0.0027533856,-0.003841422,-0.036460996,0.056126032,-0.036732443,-0.019949827,-0.05735212,-0.05719998,0.022480428,0.048345003,-0.0600912,0.0007584436,0.1221754,0.015777975,0.012691151,-0.055418063,-0.06967477,0.0857346,-0.07717345,0.054370776,0.026177129,-0.014357638,-0.0076710302,0.038475756,0.030265179,0.003104678,-0.02543703,-0.061435234,0.023048375,0.0912504,0.00952248,-0.071171366,-0.06073872,-0.0022013318,0.029692886,-2.7193613e-33,0.09174186,-0.07408081,0.038812827,-0.03934962,-0.06860317,0.09209428,0.057982277,0.05949657,0.063235186,-0.009172192,0.061016485,-0.0107156355,0.03084696,-0.031788196,-0.0099158175,-0.008824542,0.012208179,0.0029637732,0.00069249456,-0.0235481,0.034274906,0.030058578,0.060364153,0.0033602528,0.08216312,0.034292974,0.021365635,0.0013082512,0.046724495,0.045227174,-0.023060538,0.042008895,-0.0058585983,-0.045615178,-0.021634879,0.027146408,-0.06552524,-0.02616771,-0.00076969917,0.032809027,0.007854424,0.006182562,0.022153033,0.06145301,-0.0060029845,0.065079816,-0.06928178,0.011111271,-0.0035792624,-0.035325795,0.0400588,-0.0066847764,-0.01820468,-0.018704176,-0.0006726836,0.0125616025,0.039952066,0.024488842,-0.02001314,0.05908447,-0.0055922866,-0.06636484,0.042313673,-0.030847883,0.0037189517,-0.004591855,-0.017858034,0.073724635,0.0417892,-0.0025038416,0.03632873,-0.046035826,0.02720064,0.04933782,-0.04379581,-0.0032081539,-0.023378361,0.004804079,0.05124852,-0.09018141,-0.019770257,-0.03244975,-0.026741643,-0.13425393,-0.00046009166,-0.049978618,0.037548173,0.12637705,-0.023225877,0.043376602,0.032335658,-0.073015444,-0.06894457,0.06380778,0.035981525,-4.826072e-08,0.07031665,-0.14916259,0.010332486,0.00083556405,-0.01007607,0.050212577,0.00720694,0.08203526,0.063543,-0.055530105,0.020094227,0.03608125,0.05588195,0.011843581,0.00063319935,0.026777519,-0.012283736,-0.0032180294,-0.005352562,-0.026924113,-0.06673687,-0.043470133,-0.16372745,0.03818968,0.036994383,-0.0015762327,0.015341731,-0.023558946,-0.013105672,-0.0662331,0.0096315835,0.026576439,0.03752399,-0.014631868,-0.040641055,0.011547733,-0.047033902,-0.030959278,-0.10047082,0.0017624955,-0.06307131,0.014057289,-0.07334643,-0.01477688,0.038141165,0.015711091,-0.03878627,0.04355581,0.01915153,-0.015257638,0.019334283,0.0006400464,0.04150195,-0.026917554,-0.06429938,0.04344574,0.043222208,-0.08273373,0.010255716,-0.04047079,0.057325404,0.011590738,0.14587581,-0.03408865 +3.7.1.21,"The enzyme, which participates in the anaerobic benzoyl-CoA degradation pathway in certain organisms, catalyses the addition of one molecule of water to the double bound of 6-oxocyclohex-1-ene-1-carbonyl-CoA followed by the hydrolytic C-C cleavage of the alicyclic ring.",384,0.99999994,-0.09208451,0.027471023,-0.06915796,0.043451454,0.08757477,0.023003945,-0.06776199,0.015558161,0.027701812,-0.034885027,-0.049241282,-0.12491934,-0.022557998,0.0398857,-0.0999669,0.06600666,-0.14964266,0.009059671,-0.06586957,-0.04055706,-0.017598547,0.021329235,0.010613308,0.07585619,0.050687265,-0.050597362,0.018364344,0.01745226,-0.07720145,-0.062499356,0.021805499,0.018995043,0.12443051,-0.016899217,0.07480208,0.09933412,-0.0036088282,-0.09406018,0.077343896,0.014240734,0.017997723,-0.008956517,-0.044917803,-0.041614935,-0.012477336,-0.01020257,0.018560512,0.023333363,0.034745216,-0.0024276457,0.026295356,-0.048082028,-0.12524989,0.022027886,-0.028605511,-0.0140029,-0.042315364,-0.029471314,-0.03761691,0.02842273,0.07786719,0.0073984587,-0.024662402,0.10344597,-0.010756248,-0.1185371,0.031886864,-0.03269686,0.007305636,0.005504651,-0.10609561,-0.090929575,-0.0107881725,-0.036900878,-0.02050812,0.027165534,-0.005836928,-0.065925494,0.022644298,-0.06024271,-0.033852614,-0.002527957,0.02719388,0.021375231,0.037837565,0.033062976,0.059797775,-0.09641848,0.069100566,0.0040632044,-0.0044811657,0.011113913,0.017885027,-0.073593415,-0.04527294,0.062125117,0.0806435,0.0058736703,-0.031396937,0.029181452,0.013897991,0.10067696,0.007781026,-0.09551037,0.09185664,-0.0023962888,0.0306141,0.12511687,0.036151916,-0.010911163,-0.0417368,-0.0055054645,0.04669915,0.012778503,0.045556918,0.12548494,0.0049738004,0.030744165,-0.0429217,0.07383922,-0.025352279,-0.062865056,-0.020114157,0.013603295,-0.01750328,0.007294527,-0.023101026,1.8222106e-33,0.06537652,-0.021496411,0.028081888,0.009872044,-0.011295306,-0.052570853,-0.1028532,0.019588294,-0.036585085,-0.043750793,-0.0058214366,-0.005059218,0.058976784,0.042207982,-0.00608528,-0.037870757,-0.01983329,-0.0023866014,-0.006847072,0.018469883,-0.03954494,-0.029001428,-0.041451544,-0.019425252,0.0327851,0.028244676,0.003570979,0.06837031,0.019552698,0.0067165433,-0.024738133,-0.010692767,-0.10685253,0.021412492,0.019173969,-0.0025284856,-0.013879437,0.009855593,-0.0044903406,0.090432316,0.04676673,0.0037672264,-0.027161539,-0.07227022,0.034608778,-0.039974328,0.015677014,0.12848853,0.03898988,0.014465133,0.033113603,-0.06045182,0.07614978,0.00047815032,0.0049219774,0.050726656,0.009649389,-0.0062600533,-0.001058501,0.022364933,0.017792536,0.034794394,-0.039359003,0.048580322,0.024638135,-0.024614692,-0.09497097,0.008469275,0.0056330436,0.033217043,-0.09667036,0.021069754,0.047711167,0.084563866,0.002349212,-0.032851472,-0.05244799,-0.045856655,0.02274823,0.03760959,0.003111405,-0.03215359,0.059486203,-0.046970807,-0.027175087,0.027859941,0.00975795,-0.040872425,-0.022634977,0.035635047,0.046676543,-0.06322644,0.0070673623,-0.063536815,0.026250478,-3.398819e-33,0.12611105,-0.08758059,-0.030307736,-0.10517625,-0.023179946,-0.017275505,0.0033948575,-0.053117868,-0.031215953,-0.016332535,0.06217033,0.022145908,0.0010886854,-0.033028044,0.049248364,-0.044949252,0.056935415,0.017887669,0.0036939264,-0.0025437952,-0.024589175,-0.0071812323,0.006960544,-0.08871852,0.029452011,0.043323375,-0.07375081,0.026462225,0.04046052,0.06243432,-0.088507354,-0.00094460294,0.0064988513,0.053604115,0.028012712,0.11903623,-0.042196605,-0.0040892316,0.019914996,0.03975351,-0.03463935,-0.044968907,-0.02054754,0.001810232,0.121066935,0.034751512,-0.04112337,0.012367233,-0.03974019,-0.06448548,0.05548161,-0.009887443,-0.019465698,0.05536755,0.029940952,0.093043186,0.03460573,-0.068112515,-0.009814202,-0.044248577,-0.04894589,0.035925757,0.030481132,-0.005994313,-0.009512727,0.071690634,-0.046715166,0.11323277,-0.0017081187,-0.03200066,0.08624115,0.047148902,0.025879286,-0.018375361,-0.0991222,-0.024458367,-0.029882718,-0.012123411,-0.066608906,-0.034336563,-0.030437592,0.048653,-0.05650962,-0.08487936,-0.055401754,-0.11854149,-0.010736255,0.011672001,-0.002754609,0.05075051,0.01625754,-0.042138558,-0.047526278,0.08546921,0.076619156,-3.6800355e-08,0.0010637674,-0.06916408,0.031283207,-0.01003302,0.08809553,0.03601899,-0.022676406,-0.027825736,0.07488333,-0.058009185,-0.03880563,0.073035166,0.06072161,0.01684395,0.018652959,-0.0043323995,-0.020360772,-0.013556935,-0.024153968,-0.011410163,-0.07034809,-0.061589587,-0.050021812,0.0482833,0.011069593,-0.056794845,0.025379816,0.041513734,-0.048870154,0.01059838,0.046646424,0.03371485,0.03485011,0.043265093,0.041700754,-0.018922854,-0.019227684,-0.060224622,-0.078913085,0.069302335,0.025974978,0.009023456,-0.12927589,-0.014445668,0.13793364,0.023799548,-0.011044729,0.018046832,-0.00022508774,-0.018866442,0.034052063,-0.0025052966,-0.029906292,0.0028183411,-0.028455876,0.03063566,0.026404856,-0.03260308,-0.06492693,0.02528753,-0.056868557,0.045585338,0.19476971,-0.07368527 +3.7.1.22,"The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol degradation pathway leading to acetyl-CoA.",384,1.0,-0.10858522,-0.024363698,-0.05592898,0.0118150655,0.08728178,-0.06039861,-0.047699086,0.07205129,0.034048807,-0.017466098,0.028619206,-0.06924202,0.010907401,0.062334843,-0.10408566,0.097608246,-0.01872938,0.0027052178,-0.006996735,-0.048843406,0.050787736,0.105403826,-0.065657705,-0.0030115733,0.0509516,-0.040328115,0.05241185,-0.008945599,-0.05119752,-0.08142005,-0.03239087,0.026894549,0.10149858,-0.025299435,0.08846937,0.14558816,0.013413063,-0.06497582,0.1509305,-0.012284459,0.022416359,-0.009177605,-0.0029851515,0.0010929446,0.0014929273,0.003114104,-0.043099012,-0.009872709,0.057296384,0.036552664,-0.080334164,0.0075999172,-0.022505732,0.032529913,0.0044025597,0.0050637354,-0.026794044,-0.047409758,-0.01859384,0.052370828,0.07185004,-0.010262719,-0.019459682,0.0527515,-0.020694219,-0.05202842,0.0566492,-0.005672285,-0.0342722,0.0075551365,-0.039917644,-0.040492736,-0.04792885,0.15018313,0.053886857,-0.019579988,-0.032315448,-0.0501516,0.04473355,-0.03027132,0.013785714,0.033794492,-0.018985303,0.014868974,0.06559517,0.034830805,0.089523226,-0.077388436,0.020130055,0.029159263,0.031101856,-0.07433805,-0.007976042,-0.088060096,0.009127371,-0.0042286813,0.049785953,-0.041296683,0.029066779,-0.022649791,-0.030717371,0.049090818,-0.028314138,-0.03139347,-0.060383018,-0.009760509,0.026091915,0.077823415,0.089711726,0.07639193,0.0030192442,-0.05486103,0.064152054,-0.07131064,0.037648976,0.09545924,0.014739993,0.004078934,-0.055034105,0.05642288,-0.031573176,-0.027773712,-0.013971708,0.070455536,-0.052256275,0.051804043,-0.027885089,-4.7489935e-34,0.016919319,-0.021566778,0.0101393545,0.019960193,0.024419075,-0.12321174,-0.077060185,-0.023647867,-0.06653317,-0.08393484,-0.03220132,-0.09796295,-0.020660952,0.07044028,-0.04164681,0.058310773,0.011464435,-0.03497121,0.040847864,0.024212344,-0.07030694,0.0035933242,-0.015818808,0.009740966,0.014971133,0.06286593,-0.0075189034,0.022465676,0.040812496,-0.004003543,0.0593469,0.008237671,-0.117199875,-0.014260932,-0.012257938,-0.033315588,-0.040453974,-0.035285704,-0.044380352,0.09193241,0.021012673,0.06909287,-0.011815243,-0.010520591,0.02005692,-0.07192131,-0.018392116,0.06431994,0.006994811,-0.005872021,0.01771719,0.006942223,0.09478962,-0.058684062,-0.01623662,0.023887126,0.006091465,0.00036518325,0.030401984,0.02108178,0.032090627,0.062224418,-0.022974232,0.122998305,-0.076638296,0.011262743,-0.068579264,-0.017449837,0.045424283,0.031263616,-0.035589147,-0.0013654958,-0.023215853,0.024858402,-0.008599576,-0.028261164,-0.060057923,-0.0023533704,0.00617157,-0.046143178,0.017958662,-0.029872982,0.02704874,0.0062792837,-0.014496997,0.02237513,0.031905804,-0.08165861,0.0023504307,0.036879074,0.04273639,-0.07454685,-0.053715274,0.045355134,-0.00016660543,-1.7807391e-33,0.116790995,-0.124607585,0.09748987,-0.14193851,-0.13609703,0.022441775,0.007138132,0.010087456,0.037820436,0.06802905,0.064465344,0.009749183,-0.027704539,-0.020873323,0.03131565,0.019312637,0.021849101,-0.0032582174,-0.01746368,-0.01448457,-0.011042376,0.10830123,0.073425435,-0.081042826,0.042306583,0.02361074,-0.068650626,0.06263013,0.022236692,-0.00023638539,-0.015390271,-0.012060384,-0.03468017,-0.06588566,-0.06034811,0.04934846,-0.055000648,-0.013701073,-0.008784943,-0.06523642,-0.023762893,0.074251674,0.0018292704,-0.014107788,-0.0032497512,0.0058958563,-0.045651924,0.013339613,-0.015976906,-0.10518839,-0.021132616,0.008229906,0.02660564,-0.015122979,-0.0035291244,0.06651376,-0.03103058,0.039734323,-0.0017864075,-0.084816605,-0.06937555,-0.029671242,0.012533846,0.000579716,0.08080666,0.1180361,-0.008954534,0.07601433,0.017798338,-0.08343119,0.032396056,-0.014619195,0.032858416,0.04441516,-0.009603773,-0.061255205,-0.087124616,-0.0017167187,-0.00043605364,-0.018893138,-0.09659258,-0.025675977,-0.10440578,-0.03674835,-0.08625724,-0.09763937,-0.0014223411,0.1066447,0.00296512,0.019564599,-0.009146847,0.041175943,-0.062308326,-0.009969043,0.008046772,-2.7088872e-08,0.06774473,-0.07291134,0.05439018,-0.033682145,0.05976568,-0.006778588,-0.014922138,0.043962374,0.0876678,0.023170343,-0.06292888,0.10547616,0.052742995,-0.043691833,-0.0026081614,0.026841365,-0.040103517,-0.045329157,0.024125485,-0.04302651,-0.061346933,-0.00092334254,0.012336488,0.06088643,0.024399742,-0.061578166,0.06794886,0.07661318,-0.042640273,-0.029138112,-0.042852536,0.06040076,0.0113486955,-0.01868243,-0.04496144,0.032789033,-0.058837052,-0.015551925,-0.015840508,0.05160639,0.057203107,-0.004539754,-0.052183326,0.0040046955,0.03733788,0.07011744,0.014057631,0.025564047,0.03845768,-0.03513198,-0.04865985,0.003299614,-0.029708656,0.032943245,-0.0536669,-0.027096873,-0.0054698396,-0.01906297,0.03919072,-0.017954636,0.0177929,0.003389257,0.12823,-0.058298416 +4.1.1.97,"This enzyme is part of the pathway from urate to (S)-allantoin, which is present in bacteria, plants and animals (but not in humans).",384,0.99999994,-0.06499974,-0.02746285,-0.061441276,0.016711278,0.028552307,0.0149539225,0.012561207,0.03419463,0.053485584,0.051893692,-0.010854845,-0.041211564,-0.036654696,0.033432085,-0.12131222,-0.014110826,-0.08873918,-0.013395398,-0.00660814,-0.028608529,0.109819815,0.09575219,-0.04077089,-0.06008594,0.026347075,-0.036806963,0.029844277,0.005178621,-0.014569664,-0.097045094,-0.017039077,-0.0036688726,-0.0071044527,-0.05779985,0.03393943,0.10215573,0.013778712,-0.074931204,0.02000211,-0.089698404,0.09750269,-0.051374614,0.062836,-0.02622505,-0.0359507,0.044228327,-0.048021633,-0.009760158,0.036640927,0.029883359,-0.09600621,-0.05156886,-0.0055197794,0.0835248,0.06796741,0.0030115768,-0.046844903,-0.06256809,-0.041207563,-0.017224217,0.053828597,-0.03902183,0.067011006,-0.0015373045,0.015881607,-0.021738341,-0.031800397,-0.023900105,-0.0009803023,-0.09964523,-0.013867855,-0.10761106,-0.029464064,0.092752345,-0.0028233186,0.020586997,-0.01619996,-0.01560623,0.013051779,-0.03790017,0.06815543,0.014480594,0.08819911,0.065369315,0.034034234,-0.0005944336,0.052296788,0.022627806,-0.009538795,0.044056423,0.044470124,-0.040366866,-0.010939249,-0.10028211,0.06635379,-0.03326365,-0.017611086,-0.04274323,-0.025230924,-0.02474222,-0.048535075,0.059504583,-0.019538423,-0.11191888,-0.026137063,0.022895401,-0.048112836,0.0474868,0.06733657,-0.019507017,-0.02407252,-0.0048678583,0.01756808,0.06289052,-0.007934266,-0.00021625597,0.050759155,-0.030549556,-0.032747194,0.055255063,-0.069846995,0.033713207,0.024058426,0.09435262,-0.009447329,-0.017827865,-0.055549726,-5.1435317e-33,0.06459334,-0.0029081746,-0.04238194,-0.062302347,0.010059517,-0.013935434,0.014709657,-0.0019709182,0.014905215,-0.07878076,-0.13239208,-0.13337605,-0.007867676,0.034796212,-0.040508673,0.03666578,-0.0076199444,-0.021291709,0.060681596,-0.055124864,0.05522123,0.04841487,-0.07281069,-0.02560045,-0.0051451046,0.044672202,0.05499754,-0.007263644,0.034791898,-0.023046058,0.024429593,-0.01563371,-0.07709349,0.006493033,0.080253646,0.03981906,0.058457162,0.000244857,-0.053180177,0.091411486,0.016398652,-0.03403283,0.029678723,-0.06691697,0.04745927,-0.03888191,-0.11112756,0.0011426142,0.02462029,0.06861249,0.003894482,-0.034815915,0.103314765,-0.032690316,-0.11322627,-0.0005234334,-0.067081146,-0.0443937,0.010343144,-0.008078876,-0.0131410025,0.0053455723,0.005291608,0.041577075,-0.01639775,0.029989492,-0.03785114,-0.07917759,-0.020643916,0.10944479,-0.057789657,-0.070981085,0.045635484,-0.044100247,0.01637772,-0.01874585,-0.118085824,0.03797235,0.051578842,0.01961437,-0.023543723,-0.04260007,-0.0076892274,0.028816909,0.022579528,-0.02567469,-0.041175924,-0.017855288,-0.007324793,-0.058392923,0.106130995,0.0058541824,-0.1120594,0.023509895,-0.011025598,1.1915367e-33,0.09497575,-0.07667039,0.104877524,-0.011025552,-0.060840752,0.065952115,0.006691237,0.00640972,0.06162058,0.08047985,0.053484417,-0.0050858413,0.053899426,-0.11543736,0.016872084,-0.014496097,0.0039111795,-0.0039685983,0.055587705,-0.009814208,-0.11056941,0.012975842,0.021657676,-0.016457135,0.012041569,0.0018447895,0.0020038292,0.0068565835,0.048858497,0.012362926,-0.003853835,-0.008653717,-0.08003882,-0.11627047,-0.057184864,0.08661013,-0.04039551,-0.031547528,-0.026591407,-0.04201016,0.08637301,-0.014341009,0.0075715105,0.06117868,0.010481964,0.024600495,-0.0849963,0.016280504,-0.071846396,-0.06821073,0.032514513,0.038144786,0.043960277,-0.00036385574,-0.020988166,0.066850334,0.023094382,0.004325795,-0.0727441,0.026378233,0.00061459665,-0.0099923955,0.01042351,-0.021597745,-0.017782936,0.05958106,0.00016905909,0.020424755,0.0140829915,-0.056616113,0.09898449,-0.016538315,0.03577938,0.059017222,-0.002732656,-0.0641075,-0.033920527,-0.030224543,0.05914585,-0.1057544,-0.029776925,0.011429121,-0.041180626,-0.047041107,-0.012845665,-0.088997744,0.02298814,0.13826817,0.060286075,0.019692391,-0.05997749,0.03056913,-0.09190992,0.005497994,0.038305555,-2.9176244e-08,0.040997576,-0.03089046,0.02368212,0.0022819042,0.015432106,0.014755554,0.053425327,0.12597822,0.058572453,0.011159776,-0.04309787,0.038427107,-0.007295235,0.0050685476,0.08628744,0.04733936,0.016509514,0.005172566,0.0037225336,0.002568735,-0.022857748,-0.04000621,-0.05872568,0.029779982,0.048216384,-0.03783622,-0.019534033,0.09414622,-0.07547575,-0.027947363,0.02177281,0.056015864,0.010559656,-0.0074952105,-0.09025974,0.0826045,0.039675795,-0.1022529,0.029637815,-0.029995551,-0.023139447,0.022628902,0.002671611,-0.037296806,-0.021381581,0.007784685,0.032316994,0.036887087,0.0055726347,0.008319767,0.010925582,0.018804185,-0.015181394,-0.034025535,-0.011302255,0.04474443,0.050413113,-0.13007301,0.07575583,0.029784616,0.099522494,0.033588044,0.113677494,-0.0037339593 +4.1.2.55,"In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. In vitro the enzyme can also catalyse the cleavage of the non-phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with much lower catalytic efficiency. cf. EC 4.1.2.21, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, and EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.",384,0.99999994,-0.049207084,-0.09472616,-0.03476015,-0.056908816,0.015514873,-0.036965992,-0.09897683,0.040919542,0.0480902,-0.006882978,0.008687809,0.019617997,-0.08930445,0.03761974,-0.03901643,0.015452731,-0.07104422,0.042542942,0.054081533,0.03284249,0.192663,-0.019222034,-0.045233306,0.020603448,0.07882095,0.0083395885,0.018296987,-0.05817492,-0.08752105,-0.04860824,0.023144394,-0.064315714,0.05580052,-0.018230012,0.0003082504,0.100221805,-0.034130808,-0.03163588,-0.021342628,-0.032169417,0.00010918912,-0.03203975,0.010522251,-0.051845957,-0.023257636,-0.04710614,-0.04645435,0.060060587,0.019451678,-0.039803997,-0.061429977,-0.0864684,-0.077533066,-0.017568242,0.06823328,0.057710465,-0.016787797,0.0057309754,0.018134778,-0.020594396,0.05799314,0.06001073,-0.020762438,-0.028155992,0.005233986,-0.054172736,0.03535883,-0.05843958,-0.0036704824,-0.016616898,-0.014417927,-0.053000335,-0.004343845,-0.010487502,-0.007257339,0.112623416,-0.018247169,-0.025331914,-0.0072333543,-0.05094887,0.090166144,0.0283523,0.03350486,0.03486818,0.0329851,-0.04658606,0.033377018,0.044527184,0.03259102,-0.060152557,0.025512425,-0.026437914,-0.05120865,-0.00092950853,-0.0078206,0.053297307,-0.0085791815,0.08463186,0.023464711,-0.016182367,0.041469272,0.056865126,-0.021605093,-0.110248536,-0.0007276211,0.054131955,0.032387454,0.1281937,0.016314255,0.020470303,0.029412182,-0.030215463,0.028722037,0.05638864,-0.08648038,0.1524376,0.046291333,-0.051634133,-0.1153345,0.04710447,0.02134085,-0.019317193,0.09190835,-0.017053608,-0.01369045,0.054389462,-0.06615665,2.717726e-33,0.08456246,0.04334624,0.030805107,-0.0013348128,0.02851783,-0.038723253,-0.065592945,0.034849137,-0.0490188,0.012935293,-0.11656236,0.014861718,0.03761299,0.029331055,-0.07175956,0.009894993,0.017486406,0.015196142,0.014675207,0.015843749,0.022113804,0.030565714,-0.047188617,-0.0047510886,0.041816022,-0.0027321626,-0.007022801,0.011985399,0.057011943,0.006241369,0.030032888,-0.15019338,-0.09237316,0.005256318,0.037623893,-0.002039065,-0.07052883,-0.024404155,-0.0070781643,-0.020124942,0.049138643,-0.012403692,-0.008800398,-0.025644502,0.041131385,0.019373363,0.020788202,0.03585833,0.036862332,0.045122586,0.07262239,-0.010760711,0.0132678915,0.049777623,-0.039454877,0.009234086,-0.030084033,-0.008985684,0.07275564,0.050129447,0.021335976,0.044742975,-0.020549454,0.023916008,-0.0025233037,0.0064197695,-0.042948857,0.035309356,-0.035725057,0.05240893,-0.04298726,-0.05886562,0.03297935,0.033185177,-0.004464862,-0.03732195,0.06537761,0.036784846,-0.036669843,-0.027140424,-0.01743058,0.0112917265,-0.0069806688,0.0628215,-0.058521006,0.072471075,-0.03497287,0.010654458,-0.055529643,0.06847093,-0.036142237,-0.009593193,-0.096759625,0.015659472,0.010669305,-2.8087622e-33,0.117568366,-0.09364944,0.076466955,-0.122934915,-0.061136093,0.11242195,0.056507614,-0.055222686,0.083780095,-0.07512679,0.039512284,0.030391457,0.05723261,-0.09692594,-0.018072166,0.02608542,0.0056152456,0.0033707868,-0.06332431,-0.015548806,0.05047099,0.16759983,-0.020691555,0.019047607,0.030989608,-0.009766684,0.044960946,0.047907718,-0.0058351043,0.055006426,0.046257887,-0.017845022,-0.008135778,-0.08549141,-0.077057086,0.05754433,-0.10251386,-0.04805214,0.004265917,0.04890682,-0.055236045,0.04227781,0.054318517,-0.00025299581,0.07654021,0.027056936,-0.056594137,-0.026605537,0.028163154,0.0039744466,0.06558041,-0.05955768,-0.0433651,0.04168801,0.041602466,0.013882079,0.019609448,0.06724191,-0.049567148,-0.012502429,-0.014656103,-0.021715952,0.062418893,-0.10658969,0.03162136,0.019335186,-0.05347859,0.0036490539,-0.0047177374,0.018037131,0.017496074,-0.026519114,-0.07043924,0.0885045,-0.011546683,0.039038826,-0.09311572,-0.019997004,-0.045194246,-0.07075083,0.005285974,0.01571933,0.027986297,-0.026764736,0.011290794,-0.060450528,0.07396694,0.10381892,-0.023026071,0.018505512,-0.034912623,-0.039699662,-0.013944893,0.011536635,0.057837754,-4.90212e-08,0.030173983,0.018214297,0.015493985,-0.032678623,-0.07829556,-0.0012460258,0.041985735,0.04422335,0.03720887,-0.0780976,0.015139796,0.085403346,-0.025048187,0.008598181,0.0018612792,0.014525091,-0.039989125,-0.00916344,-0.044223167,-0.039133664,-0.003401007,-0.010372052,-0.10193636,0.0026614508,0.0446308,-0.03775167,0.06893055,0.015301216,-0.046654858,-0.042564694,0.06153837,0.018033756,0.025592178,-0.023708994,-0.0069340896,0.041466773,-0.090072125,-0.0043247016,0.0064644367,0.033143785,0.040596563,-0.06393771,0.01267794,0.01921521,-0.084302716,0.043783277,-0.027372701,0.103114955,-0.0029669653,0.085213795,0.034852423,0.016828448,-0.07056926,-0.088970356,-0.06614958,-0.01840998,0.020374585,-0.039658677,0.042973083,-0.05693081,0.0990971,-0.042778406,0.13452527,-0.008811707 +4.1.2.56,"Part of the pathway for the biosynthesis of grixazone, a mixture of yellow pigments produced by the bacterium Streptomyces griseus.",384,1.0,-0.03470821,0.06430951,-0.14633556,-0.035405066,0.004574552,0.070465535,0.063234754,-0.01268394,0.05422971,-0.045691133,-0.04455442,-0.040111165,0.03011157,-0.0148423845,-0.06347063,-0.027687814,-0.083860144,-0.0041302475,-0.01839182,-0.01096692,0.13096154,0.011734189,0.038074702,-0.034082334,0.04617637,0.037350718,0.034639835,0.0044129565,0.02448832,-0.075411245,0.055285215,0.05228917,0.07140803,-0.07303492,0.04963088,0.061405603,0.025401661,-0.026975207,0.06579562,0.07743528,0.01595038,0.050995156,-0.011528738,0.049634136,-0.05547544,0.04140071,0.039859623,0.10196087,-0.057682328,-0.023711184,-0.07612872,-0.11333624,-0.030576866,-0.012024506,0.037011985,0.07629845,-0.01087893,-0.01939657,-0.002350049,-0.043606266,0.082402445,-0.06442977,0.0023414774,0.0040012836,-0.09871715,-0.033682816,0.016540717,-0.102926515,0.0021407097,-0.06841453,-0.040500395,-0.034089796,0.005207812,0.022978788,-0.05039769,0.098484114,0.06744094,-0.022144224,-0.088301264,-0.055688456,0.09863519,0.038015354,-0.007604247,0.1024498,0.11511195,0.022258228,0.035522867,0.037513815,0.03395934,0.05874835,0.038190473,0.0027516538,0.06413549,-0.030988533,-0.057606284,0.09537233,-0.041153904,-0.056713935,0.042723212,-0.038103886,0.0086419545,-0.04781116,0.066682264,0.018042568,-0.020317385,-0.011599324,-0.0551444,0.12339817,-0.07541254,-0.029450826,-0.011415502,0.008308526,0.047117736,-0.00642025,0.01766944,0.07000582,0.11039513,-0.008497129,-0.045994688,0.038426567,0.02125736,0.039314337,-0.01251985,0.0063210474,0.004638814,0.02659942,-0.054037184,2.2115969e-34,0.02485016,0.050128218,-0.041939694,-0.06906869,0.014989623,0.012272837,-0.07319267,-0.037440006,-0.02182934,-0.071250364,-0.07861185,-0.05831039,-0.04390781,0.04224962,-0.012928583,0.047996577,0.022632997,0.02721344,-0.008883933,-0.031333223,-0.027155537,0.028046358,-0.068164654,-0.017847935,-0.05211227,0.059375428,-0.00490664,0.013771829,0.060551796,-0.07835329,0.056959566,0.01134949,0.030262496,0.04664001,0.021734007,0.006550812,-0.003125727,-0.026816033,-0.018653642,0.08085765,-0.06104683,0.054149203,0.00052396546,0.007849847,0.0601588,-0.022916166,-0.08495573,0.03725182,0.0890243,0.033604316,0.020140892,0.030213974,0.08452096,0.05795292,-0.13290878,0.056750376,-0.0046251053,0.03649522,0.06271144,-0.05380695,-0.054140657,0.05873934,0.06331885,0.03694114,0.05045598,-0.01806098,-0.028079,-0.005151586,-0.040684473,0.057525277,-0.043593805,-0.052433796,0.047800004,-0.026170177,0.020294879,0.0046203323,-0.06934423,-0.12974963,0.0036461165,-0.011121325,-0.04833916,0.014304101,-0.09126104,-0.07934763,-0.07601363,0.015101847,-0.046405215,0.022725305,0.010186464,-0.0063063023,-0.017594054,-0.027533282,-0.101501636,-0.00815689,-0.009588034,-1.0361588e-33,0.09927654,-0.040641844,0.06360002,-0.025648884,-0.030315936,0.04225299,-0.060871635,-0.059140824,-0.06340615,0.0432788,0.035940286,-0.025845297,-0.023148773,-0.007607705,-0.04972179,-0.056597844,0.08805874,0.16340835,-0.029002381,-0.046572357,-0.013348068,0.06162626,-0.038879618,-0.045442205,-0.0006330819,0.036172718,0.043298114,0.031833075,-0.01618456,0.04850359,0.016596941,-0.06436809,-0.07564956,-0.074359916,0.01155021,0.06428573,-0.017813103,0.01319135,0.030320896,-0.02810806,0.012825621,-0.04247633,0.058014963,0.121938564,0.1231865,0.037011366,-0.021649577,0.04789351,-0.029626274,0.0030311656,-0.0128921205,0.0497816,-0.006786756,0.010030323,0.044601846,-0.0479267,-0.015251303,-0.03090632,0.010798844,0.009806553,-0.019666942,-0.00040364082,-0.05886636,-0.029710187,0.07108075,0.020066423,-0.004582946,0.12537622,0.06569885,0.014661829,0.037735645,0.053808942,-0.014364404,0.07580664,-0.026620377,0.017813118,-0.10271706,-0.07135143,-0.020736014,0.0046100738,-0.01521092,-0.011665965,0.031665947,0.0025424513,-0.024172155,-0.076012455,-0.022708233,0.06843335,0.076351315,-0.030717716,-0.011977706,0.03837754,-0.005315586,-0.009976066,-0.01064316,-2.5055595e-08,0.06608284,-0.06371286,0.05111746,-0.028070776,0.025558583,-0.03634139,-0.03908114,0.015540581,0.124696985,-0.040486686,-0.057575367,0.006959029,0.00082441035,0.02049,0.039250106,0.06668199,-0.0005659952,-0.05918833,0.00966702,-0.023307325,-0.080760725,-0.029898327,-0.08984138,0.045666195,0.0060837413,-0.089526065,-0.012573592,0.04423154,-0.014010448,0.042556893,0.051275972,0.029496942,0.026880454,0.024686921,-0.0022252162,0.007941908,-0.033360425,-0.036185306,0.016253484,-0.0954786,-0.018333957,-0.065147735,-0.024534289,0.008854628,-0.09121944,0.0028551053,-0.008995311,-0.04116487,-0.0319319,-0.006302827,-0.0022471268,-0.005733211,0.00902059,0.015218421,-0.10365953,-0.046987306,0.031758543,-7.103587e-05,0.0078997435,-0.03542713,-0.045885917,-0.008545921,0.116839714,-0.033794772 +4.1.3.46,"Requires Mn2+ ions for activity. The enzyme, purified from the bacterium Chloroflexus aurantiacus, has no activity with (3S)-citramalyl-CoA (cf. EC 4.1.3.25, (S)-citramalyl-CoA lyase).",384,1.0,-0.058886427,-0.09310908,-0.06898841,-0.020701267,0.06983683,0.0072470224,-0.014027899,-0.016771605,0.014374295,0.023730472,0.029428918,-0.12523763,0.07474635,0.07709999,-0.0048871925,-0.0058115628,-0.06565451,-0.03914397,0.010339735,0.0034430115,0.06865887,0.028801335,-0.07124086,-0.04624761,0.054564357,0.080870725,0.040220533,-0.14140981,0.0023094947,-0.028782997,-0.048261672,-0.0054505887,0.15214825,-0.10603112,0.08032456,0.08287043,-0.040524352,-0.092082635,0.005695393,0.036765713,-0.035317928,0.025813503,0.056407977,-0.019902159,-0.074664585,-0.0185945,0.1030726,-0.108494245,0.017494597,0.058951754,-0.048318554,-0.037789635,-0.024295406,0.03478379,-0.053250197,-0.008302482,-0.08327063,0.015467723,-0.04007151,-0.02567916,0.033855036,-0.0021884006,0.059368998,0.046717465,0.018998371,-0.04983347,-0.0001269478,-0.05265443,0.013172734,-0.052705057,0.0057872576,-0.02972187,-0.07128016,-0.009446116,-0.015239965,0.019636584,0.11356925,-0.04879035,0.011816739,0.00078494335,-0.09066533,-0.0040573454,0.08074161,0.09488012,0.036092333,0.075006716,0.0084307175,0.002159755,-0.028273016,0.014755559,0.05134141,0.04308673,-0.027619833,-0.031060949,-0.020844812,0.06658759,-0.0458004,0.02945372,0.0064197266,0.007879502,-0.010495678,0.10166895,-0.062127672,-0.04518851,0.012528108,-0.017889844,-0.016478349,0.06602516,0.0011522425,0.040533904,0.05295432,0.012942555,-0.002878729,0.035288066,0.050690938,0.058455512,0.105665974,-0.109892845,-0.02240106,0.048329946,0.048816986,-0.0350054,-0.012984131,0.03164543,-0.03272413,0.11339106,-0.017913949,6.046159e-34,0.0064181676,0.0037699253,0.038496546,-0.017586883,-0.04322211,-0.011129724,-0.055232972,0.0033623043,-0.003959594,-0.07454823,-0.065760806,-0.022224225,0.055141512,0.04879,0.008666049,-0.0061768126,0.029606028,-0.09776601,0.13321082,0.023873266,0.03823489,0.034424026,-0.009656242,0.025247857,0.009387266,0.041959375,0.10436593,0.0065687974,0.09575132,-0.013296135,0.016162157,-0.13336718,-0.056774024,-0.005867459,0.060383063,0.0736962,-0.07362697,-0.0018675502,-0.06649566,0.03440352,0.01822696,0.050944123,-0.08653274,-0.001162291,0.0736347,-0.06532677,-0.05400525,0.0380773,-0.033631764,0.0091473,0.0019534314,0.048784085,0.07546408,-0.04509473,-0.03380119,0.061294984,0.05007989,0.038484666,0.011075369,0.0138234645,-0.02166742,0.050966453,-0.0065645757,0.09945477,0.04757249,0.04733824,-0.07316483,-0.066112265,0.015660267,-0.0001931644,-0.09286347,-0.07755021,-0.0043718866,-0.00556617,0.034461603,-0.08346574,-0.06724007,-0.027963016,0.06312355,-0.0007054785,0.015633106,-0.055656653,0.07212889,-0.012335843,-0.05251037,-0.05729668,-0.0415237,-0.017222917,0.009847793,0.0042033,0.09654238,-0.012086759,-0.047808517,0.037585873,-0.030259786,-2.2730114e-33,0.041910697,-0.082422666,0.042945817,-0.07085904,-0.10416343,0.0789835,-0.04195492,-0.07021549,0.03338283,-0.014093829,0.110994466,0.038675375,-0.08471389,-0.030592691,0.04844943,0.021041118,0.05406432,0.0871838,0.003172012,0.015786514,-0.024712427,0.06982698,0.041055765,-0.009174631,0.0063836253,0.024962354,-0.0029695444,0.038108006,0.0076903794,-0.030729638,-0.03070101,-0.033374287,-0.021438425,-0.07098682,-0.043685734,-0.029562714,-0.056973632,-0.018242966,0.019841792,0.029709443,0.0034027738,0.029306173,0.04478647,0.071399435,-0.035618417,-0.011467739,-0.08597456,-0.0031888566,-0.023395384,-0.040028594,-0.0028336663,-0.029023472,-0.055707365,-0.036822017,0.07444237,0.021691997,0.018633697,0.040569454,0.050870072,-0.061026644,-0.031294294,-0.03384898,-0.014153785,-0.023046862,0.07602517,0.08040391,-0.017908169,0.10600396,0.0023596808,-0.038394064,0.05970951,0.034808517,0.046233833,-0.039550778,-0.039356276,-0.031490806,-0.06733755,-0.0027985603,0.041933917,-0.064543635,-0.0006834002,0.019901538,-0.0137131475,-0.09172481,0.02604388,-0.079232246,0.017289162,0.032159448,-0.014926987,0.014745092,-0.02714328,-0.057198826,0.0004958238,0.035203867,0.08200564,-3.9392408e-08,-0.016811702,-0.02520273,-0.015634624,-0.06517943,-0.007861369,0.034716118,-0.017864982,-0.06677592,0.081483394,0.038500376,0.028095545,-0.001015271,0.017012237,-0.013318144,0.059751634,0.026614854,0.033168618,-0.0054944227,-0.008833303,0.015569238,-0.07244922,-0.003395027,-0.12699553,0.074563324,0.03541774,-0.0028491432,0.042609874,0.014232473,0.011808961,0.010818673,-0.06876805,0.041868884,0.00022606779,-0.023931738,-0.07881935,-0.017234333,0.020629942,-0.060519326,-0.06683731,0.038109854,-0.040145446,0.04779355,-0.043870047,-0.02011774,-0.02528217,-0.02548967,0.008611259,0.052549686,-0.036552504,-0.04825277,0.01926515,-0.074935645,-0.046893902,-0.01342383,-0.05336031,0.02169691,0.014637005,-0.113277994,-0.07513068,-0.020135228,0.041537847,-0.016902046,0.13161632,-0.020707658 +4.2.1.147,Found in methylotrophic bacteria and methanogenic archaea.,384,0.99999994,-0.02405837,0.0030422823,-0.06327446,-0.014055304,0.032238718,-0.008101544,-0.07137217,-0.02948215,0.03604439,-0.028038718,0.017540941,-0.12028583,-0.013359853,-0.025287276,-0.026582526,0.07690415,-0.023924364,-0.07127676,0.07056555,0.06574767,0.070606664,0.17545718,-0.04771798,-0.042226177,-0.064585395,0.040287692,-0.01787217,0.0069633266,0.0044158367,-0.0085995495,0.020037444,0.049750764,0.102667704,-0.005805367,0.13798259,0.08493381,0.022087215,-0.037606537,0.08125878,-0.018849412,0.03850865,0.021777617,0.12462436,-0.006038442,-0.06938238,0.038214974,0.03919126,-0.029982446,0.05207256,-0.1337974,-0.043060895,-0.06483086,-0.0041339765,0.066056594,0.05747934,0.048662193,0.0019718097,-0.059402086,0.004556369,-0.055607945,0.061728146,0.03037049,0.025696887,-0.041740935,-0.06427371,-0.0056350655,0.024160294,-0.051014364,0.13575931,-0.022023799,-0.024248444,0.033832874,-0.025561925,0.028283972,-0.06842649,0.012525813,0.079694055,-0.105557136,0.05010586,-0.0781989,-0.026123906,0.035839364,0.037030302,-0.066807784,0.054507047,-0.04395607,0.020555276,0.049816255,0.016228834,-0.047400113,-0.012682252,0.00077665935,0.023473546,-0.121480666,-0.08321229,-0.012612786,0.08770125,0.03693549,0.056254126,0.016243657,-0.00429824,0.023538664,-0.09152136,-0.03673595,-0.07040348,-0.053597473,0.053113937,0.11972702,0.006736821,0.05483936,0.047782756,0.037265185,0.0096256,-0.0032815402,0.016869288,-0.029381184,0.07390759,-0.03791519,-0.08088897,-0.03342177,-0.08422955,-0.07130525,0.08827433,-0.04031161,-0.005182661,-0.037144996,-0.10609467,-1.0815035e-34,0.08817097,-0.02708887,-0.0021786967,-0.07572473,0.06566126,-0.03075015,0.00038523154,-0.024739118,0.050622895,-0.038732782,-0.067610785,-0.060348812,0.027081242,0.006486444,-0.086243294,0.017431358,-0.07318431,-0.014301395,-0.0040007047,-0.056064647,-0.07975426,0.040126927,0.047606673,-0.047172945,-0.023227016,-0.05038643,0.02123152,-0.086807355,0.08575028,0.013645225,0.026303727,-0.095325366,-0.08050749,0.019803748,0.08253404,0.10946092,-0.09888509,0.017395865,-0.047199342,0.030063516,0.028694818,0.04010305,0.026041191,-0.03815188,0.02043608,0.056653183,-0.033678725,0.07269759,0.0050528846,0.0015002273,-0.04021108,0.0024092204,0.0033485123,-0.03134452,-0.09150384,-0.03371216,0.053659335,-0.013574487,-0.0141732395,0.057356313,-0.041195404,0.057662774,0.0011401842,0.08606221,0.014122561,0.002343066,-0.019205892,-0.0027773723,0.049523573,0.04343068,0.023128884,-0.047822762,0.030336063,0.040298432,-0.024144152,-0.029539159,-0.02241335,-0.08150685,0.019437011,-0.007532316,0.045295473,-0.031722,0.026322454,-0.04618677,-0.052494373,0.067772694,-0.00616521,-0.04348011,0.0349717,0.02182548,0.011700567,-0.0400441,-0.029355304,-0.015977923,-0.06836823,-1.561776e-33,0.042447824,-0.029756801,0.06833094,-0.06978736,-0.025203401,0.0756918,-0.056154836,0.011147497,-0.026601186,-0.07426827,0.16962543,0.050243482,0.024706367,0.0020260843,0.08740089,-0.024248827,0.04908868,0.051631425,0.02516174,0.018595636,0.078479886,-0.043466814,-0.09012005,0.003995552,0.0073022824,-0.00080499024,0.0018652603,0.009797596,0.0035609817,-0.017100845,0.017549321,0.050566576,-0.05726573,-0.092571214,-0.04206387,0.013191956,-0.07257065,-0.08176615,-0.05363432,0.014805433,0.020514293,0.04802926,-0.02904391,0.06336337,0.030538028,0.022239296,-0.061564732,0.006830015,0.063204296,0.024077907,0.011769724,-0.119413264,0.014641277,-0.07383311,0.014369331,0.039567173,-0.035179246,0.09273765,-0.0038356357,-0.008714436,-0.054134984,-0.04445553,-0.0015501826,0.011510108,0.043992877,0.047978923,0.056742452,0.024334867,-0.047403228,-0.00809512,-0.03730424,0.024850436,0.003357011,0.022153758,-0.039921377,-0.044337526,-0.07098869,0.015561789,0.046654433,0.012169028,0.037934266,-0.0067636743,0.057787556,-0.001099024,0.012021593,-0.0168688,0.048128225,-0.017155163,-0.05540601,0.018521843,-0.087808475,0.012283355,-0.052536782,0.012396699,0.040640745,-2.02242e-08,0.07403191,-0.03739403,0.040209852,-0.03983026,-0.02255167,0.05806188,0.018065669,0.023482619,0.03282359,0.0012591077,0.053494103,0.004884703,0.011818839,-0.00014565681,-0.037923004,0.03492935,-0.04982344,-0.06423555,-0.018929897,0.007763759,-0.026930049,0.024637097,0.04687553,0.0153887905,-0.004977185,-0.009464139,0.014363922,0.0442691,-0.01373554,-0.04619908,0.010945511,0.04857546,0.015180479,-0.0120590255,-0.04239547,-0.014740967,-0.085229434,-0.03081953,-0.04998675,-0.007908571,0.054190926,0.062324207,-0.06427767,0.008542295,0.058358416,0.0045290366,-0.07123926,0.13354367,-0.07428463,-0.014550013,-0.0076469425,0.021451894,0.056724463,-0.008517074,-0.07808023,-0.033881973,0.0007278027,-0.038690984,-0.08294077,0.049532756,0.059844535,-0.036890782,0.07633555,0.0062664477 +4.2.1.148,The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.,384,1.0,-0.053242575,-0.060322918,-0.068384565,-0.04093896,0.052273616,0.033516582,-0.01462609,-0.04123601,0.025288157,-0.013940716,0.01787962,-0.15106085,0.017638685,-0.004891532,-0.03194453,-0.016503202,-0.08814292,-0.020847205,0.003036615,-0.0395703,0.065764844,0.011132333,-0.07774432,0.024461478,0.04468589,0.010335686,-0.028843014,-0.08297934,-0.003485016,-0.028059546,0.0005597545,0.05786665,0.03930747,-0.03126557,0.097287595,0.070982724,-0.024224516,-0.106087506,0.052346576,0.04551179,-0.016956307,0.029780246,-0.011653648,-0.021337966,-0.035529684,0.030998886,0.04417149,0.045212954,0.091294475,-0.055409484,-0.026630184,-0.079628944,-0.10599327,-0.008858817,-0.035793714,0.037523635,0.015871163,-0.0012029229,0.061234627,-0.0024766019,-0.015000936,0.030030034,0.033542626,0.07357997,0.066892944,-0.064827725,0.00012283107,-0.050444964,-0.035002314,-0.03460194,-0.08374928,-0.023983996,-0.024759319,-0.007469071,0.027541837,0.031187888,0.04024774,-0.05731116,0.012464188,-0.058982633,0.0028241118,0.014227097,-0.02416905,0.07229661,-0.014143701,-0.03402497,0.012227487,-0.079567716,0.036009174,0.039758805,-0.018247945,0.0208406,0.004202773,-0.02560111,-0.069052316,0.08996492,0.052214064,0.04299173,0.12448819,-0.042541437,-0.015192832,-0.04421283,0.021026408,-0.11488384,-0.07151671,-0.016041655,-0.03511695,0.10897782,0.042381573,-0.0014923854,-0.08199218,0.06993874,0.010377652,0.010714597,0.051032823,0.11145102,0.09800468,-0.06513765,-0.043243267,0.01382444,-0.008576281,-0.063728586,0.056873616,0.04072175,-0.04180935,0.08631608,-0.0069529493,1.2547365e-33,0.002622366,-0.047439877,0.026795981,-0.051509053,-0.014266966,-0.009384036,-0.106337026,-0.07318177,-0.092112735,-0.11754073,-0.048756577,-0.005077816,-0.0071200477,-0.004564555,-0.018151546,-0.051146,-0.057469245,0.014146405,0.03524347,0.045395263,-0.006617267,0.0105283335,-0.047616284,0.02752505,0.014421176,-0.011638446,0.048989158,0.015163645,0.049316447,-0.012044679,0.053171884,-0.02805192,-0.093632415,-0.008505336,0.07020065,-0.009518561,0.05020792,-0.022723688,-0.059941456,0.04969451,0.014611666,0.046370734,0.0144492155,-0.101128675,0.07523494,-0.038578082,-0.045923166,0.051349685,0.0801037,0.057952467,-0.048949886,0.02355227,0.13414863,-0.052715853,-0.038050767,0.06619868,0.034237828,-0.03426741,-0.012870102,0.002428171,-0.00890413,0.09716707,-0.04091528,0.012726228,0.011856358,0.085891515,-0.022511888,-0.0020085324,0.07271421,0.020040656,-0.12066567,-0.0294416,0.015764922,0.06424677,0.059774876,-0.06272378,-0.043700974,0.001867235,-0.004911221,-0.040960994,-0.037758205,0.022540778,0.04802642,0.020655632,-0.044224925,-0.010815409,-0.022553278,0.0032651762,-0.03164797,0.03764797,0.124193564,-0.07826199,-0.0231303,-0.009322885,-0.057266254,-2.6311141e-33,0.101168565,-0.09867864,0.041397743,-0.035737872,-0.009531925,-0.0052998653,-0.0028631496,0.015074765,-0.028123993,-0.009080004,0.103297345,0.051128387,-0.027834052,-0.006041846,0.013896944,-0.010009881,0.03758368,0.07960796,-0.022745201,0.027947173,0.035548393,-0.034301728,0.07194774,-0.017610546,0.011522024,0.018554315,-0.015762078,0.06364741,0.08915236,-0.008642485,-0.08261827,0.045109764,-0.013337214,-0.012361096,-0.06218185,0.01845499,-0.04737983,0.016996833,0.019389395,0.023126103,-0.062849246,-0.0030145552,-0.041974,-0.033347804,0.030855263,0.12072591,-0.0175353,-0.003730261,-0.018483993,0.041181985,0.028139025,0.0030425715,0.046933983,0.037163,0.037115276,0.0012148763,0.08180655,0.08596558,0.05100767,-0.0962465,-0.06491704,0.0095275715,0.032010905,-0.05735138,0.032543074,0.05215638,-0.048400495,0.053877294,0.029065723,-0.03840808,0.070214786,-0.019717952,-0.0055199284,-0.020168932,-0.050951425,-0.039603937,-0.047613047,-0.050873853,-0.019353626,0.005893585,-0.014836208,0.06061477,-0.004080348,-0.027055066,-0.013601584,-0.11347629,-0.016382694,0.016247688,0.01071541,0.07588301,-0.042598173,-0.011019853,-0.049001362,0.023875752,0.10311691,-2.8479361e-08,-0.041053843,0.024923908,0.08632603,0.009805324,0.032395177,0.020708568,0.044519242,0.0016325142,0.0895269,-0.020318128,0.020924473,0.05767371,0.10511963,-0.060345907,-0.027474811,0.02114208,-0.05901759,-0.044623755,0.017860059,0.02769244,-0.06813061,-0.016798465,-0.11593445,0.05947466,0.060071513,-0.05460853,0.048060976,0.058768257,-0.0060315924,-0.02631072,-0.07481303,0.051753577,-0.0015981132,-0.04677502,-0.071033336,0.0069472836,-0.13494413,-0.011024554,-0.0333717,0.034056686,0.028445875,0.046875637,-0.053056546,-0.02142428,0.072878696,0.033698756,-0.04813619,0.032164387,0.036557242,-0.03533793,0.049460843,-0.043393444,-0.039290074,-0.008347945,-0.06581854,0.024441078,-0.013151931,-0.11600681,-0.021906275,-0.0077425726,-0.04095369,0.053818554,0.12829472,-0.050588623 +4.2.1.149,"The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2].",384,0.99999994,-0.031190917,-0.08407877,-0.03724938,-0.024791978,0.012234302,0.022479357,-0.077114105,0.06398812,-0.021580936,-0.011760391,-0.009790248,-0.038335584,-0.056352723,0.08472703,-0.0008075261,0.06675892,0.03484161,-0.05903377,0.05058325,-0.015880529,0.059879,-0.03775206,-0.041313846,0.045384064,0.070924334,-0.0012216064,0.003528809,0.015477249,0.049896337,0.015533268,0.022870716,-0.019276153,0.0035623633,-0.027793942,0.0014558139,0.053302314,-0.047880307,-0.06488605,0.016078832,0.010707434,0.03650593,-0.015623081,-0.042062342,-0.016654294,-0.07289388,-0.08503397,0.022957288,-0.013198782,0.011915393,-0.003832874,-0.053349663,-0.03896682,-0.060058456,0.009332367,0.010942102,0.07266138,-0.071938,0.0097413985,-0.019565811,0.030735793,-0.01110951,-0.009016512,-0.018709652,0.00027302036,0.020174354,-0.05327791,-0.021784592,0.01118156,0.041409895,-0.00078093656,-0.022286275,-0.08291634,-0.027746672,-0.0071686557,0.022044366,-0.062191717,-0.0035203295,-0.058202866,0.013240279,0.029553788,-0.036602292,0.044870406,0.024860224,0.11027356,0.07104719,0.07088949,0.030185863,-0.029298278,-0.0011758304,-0.051188502,0.054462556,0.0077272286,-0.006686126,-0.024512162,-0.06454363,0.0511388,0.030930588,-0.02125705,0.012298417,-0.027117712,0.008645028,0.07467443,-0.05175167,-0.068956256,-0.081928775,0.024740102,0.012621864,0.12099184,-0.011527148,-0.02193495,-0.009862976,0.04091286,0.031672575,0.00039377104,0.0048772953,0.103532255,-0.059538197,-0.021300733,0.021795714,0.052241012,0.008442267,-0.037744205,-0.024929726,0.0404223,0.0003039479,0.05143746,-0.051522426,-2.726922e-33,0.033981662,0.053955425,0.0013277933,-0.080490224,-0.04894803,0.01824545,-0.0872638,0.06681514,-0.08991587,-0.09311854,-0.02758901,-0.08370193,0.034350883,0.07076825,0.045239396,-0.059873864,-0.007949066,0.009176681,0.10894467,0.057641067,0.01870318,0.0074776663,-0.040049676,0.040769376,-0.044596776,-0.0034668278,-0.013979636,0.12276513,0.025856767,0.008312059,0.01897207,0.030099856,-0.05089924,0.016146831,0.029466853,-0.01867427,-0.09036749,0.03185591,-0.06091017,0.11045065,0.05867047,0.07052176,0.015769644,-0.063044816,0.08249085,-0.10620976,-0.058233052,0.033243515,0.024356743,0.031913158,0.08938032,0.018177604,0.076871745,-0.011914351,-0.04100033,0.048233386,0.0076971003,-0.042980224,0.07295787,-0.0010321615,-0.06701843,0.012091241,-0.009843026,0.040730726,0.025061097,0.046488296,-0.045790806,-0.063614495,-0.06867683,0.0573659,-0.030118879,0.03216743,-0.0049786284,-0.044936065,0.063854456,-0.09058967,-0.02886577,0.043537375,0.08259936,-0.009155452,0.040436085,-0.053079143,0.030472727,-0.022449866,-0.049429473,-0.10192333,-0.0006512945,-0.020705912,-0.017365852,0.06372058,0.06386727,-0.11120436,-0.018416204,-0.0072735087,-0.052782606,1.51918355e-33,0.10860155,-0.08869322,0.04436055,-0.050567903,-0.077049576,0.1311372,0.08550563,-0.07396079,0.07824069,0.02098725,0.093953,0.039558712,-0.04975217,-0.027690768,0.021217516,0.08584255,-0.04759838,0.012100746,-0.004746853,-0.001498091,0.01828107,0.095786974,0.03064296,-0.0037808155,0.08134067,-0.017151548,-0.0346042,0.06934533,0.06457467,-0.03092706,-0.037342645,-0.07030473,-0.020985914,-0.046578906,-0.03802258,0.06218641,-0.041132502,-0.0020511062,0.0023963558,0.008858103,0.041890595,0.054478716,0.03617877,0.084080234,-0.045844037,0.05579814,-0.09226419,-0.008819391,-0.03567117,-0.033358235,0.0044481466,-0.012924985,-0.06937215,0.0032224345,0.0082599055,0.024402207,0.0038395855,0.018821513,-0.008264058,-0.03989103,-0.051545527,0.00021478735,-0.046736993,0.008063271,0.08920097,0.055568572,-0.06868786,0.063805886,-0.0333677,0.0072384817,0.08403286,0.038302872,0.06253623,0.040789884,-0.03650315,-0.03752249,-0.089728855,-0.001704776,-0.04034325,0.0101181865,0.019870955,-0.01035596,-0.012468289,-0.06656542,-0.046505924,-0.07255055,-0.006928905,0.05942837,0.030937383,0.04438462,0.0016833398,-0.02729232,0.032888494,0.041502986,0.19587137,-2.4500107e-08,0.016061151,-0.15106615,0.012231268,-0.031210087,0.004209116,-0.010860098,0.008631927,-0.021791795,0.039260656,-0.007206053,-0.06619342,0.029634356,0.006066892,0.0354868,-0.0056062476,0.021685736,0.009820669,-0.012812302,-0.030284999,-0.043968137,-0.08012149,-0.0053592254,-0.05490806,0.060730737,-0.005576776,-0.068173826,0.006428896,0.085695244,-0.021699838,-0.036734115,-0.018479541,0.012889379,0.008111065,0.024069646,-0.0773656,0.01848536,-0.01391773,-0.038512047,-0.08290706,0.035845432,0.056040104,-0.06618875,-0.052389715,-0.011419628,0.06271001,0.0057508238,0.007953146,0.008061246,0.007050598,0.03270601,0.05986281,-0.0010742157,-0.01508505,-0.084870696,-0.09632806,-0.0061108153,-0.01846481,-0.094803415,-0.052717496,-0.078092724,0.026401108,0.07488972,0.21292883,-0.03381151 +4.2.1.150,"The enzyme from the bacterium Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents. It is specific for short, C4-C6, chain length substrates and exhibits an extremely high turnover number for crotonyl-CoA. cf. EC 4.2.1.17, enoyl-CoA hydratase and EC 4.2.1.74, long-chain-enoyl-CoA hydratase.",384,0.99999994,-0.037831515,-0.06891743,-0.06648575,-0.05021523,0.07768485,0.051261544,-0.08685179,0.015720079,0.047414266,-0.06537067,0.014344691,-0.09316527,-0.016377317,0.03280855,-0.07659867,-0.020584574,-0.0398778,-0.1027964,0.041504152,-0.0074582887,0.054129664,0.033383828,-0.017104033,0.043572832,0.039742894,0.022459831,0.043452628,-0.0020366383,-0.016685883,-0.057710685,-0.0059894775,0.018558454,0.07448078,-0.0017239698,0.099071,0.06673927,-0.025902122,-0.039632984,0.14218716,0.06742516,0.040985662,0.019023823,0.0030431596,0.0009331521,-0.07469538,-0.04868933,-0.015418514,-0.0042919973,0.010017003,0.020133156,-0.019850506,-0.058091935,-0.02787904,0.028888453,0.052225236,0.029980808,-0.029416198,-0.052295357,-0.009080091,0.04890227,0.051893815,-0.034938484,-0.020105278,0.009604816,-0.0013718136,-0.08533518,0.05424222,-0.0169986,-0.0044138767,-0.023398437,-0.06778718,-0.025485976,-0.01856217,0.055779845,0.044839937,-0.022317098,-0.00554785,-0.087064706,-0.0144306235,-0.061755043,-0.04165679,0.004670558,-0.025113162,0.073468156,0.057870287,-0.012573273,0.06949958,-0.050633185,0.030457268,0.0011715859,0.040176034,-0.009818139,0.0076742778,-0.13858603,-0.06436458,0.08726463,0.034062073,-0.02002295,0.03897463,-0.040448487,-0.022112614,0.09138938,-0.015415259,-0.0727879,-0.031560473,-0.012904518,0.022863956,0.19295311,0.00219215,-0.030637866,-0.0027552065,0.025492726,0.04005471,0.001368388,0.04606582,0.022458375,-0.009175742,-0.04827725,-0.03341859,0.06037086,-0.010775698,-0.025091304,0.020415772,0.063948676,-0.006664608,0.058481466,-0.027334135,1.4706171e-33,0.076477244,-0.0048673684,0.020299079,-0.019552562,0.008015881,0.034485307,-0.08260828,0.03263639,-0.064907745,-0.043633293,-0.039748758,-0.08014973,0.026635578,0.0034683626,-0.00013476369,-0.014996138,-0.011685472,0.043175537,0.023179665,0.034577556,-0.0077950135,0.025578551,0.023517054,0.014392617,0.014375213,0.026270963,-0.019571388,0.07338243,0.019718263,-0.016215766,0.038467947,0.0651485,-0.048236035,-0.015332577,0.056038912,-0.02611248,-0.057394776,0.010334961,-0.047320895,0.10765744,0.06927731,0.09582975,-0.016999444,-0.06397028,-0.032663666,-0.05256518,-0.03596594,0.11101941,0.007790266,0.045964826,0.032505482,0.02449153,0.11778893,-0.051457833,-0.045174,0.04968688,-0.035271112,-0.043439586,0.05617966,-0.012485561,-0.010558635,0.087170325,-0.040577028,0.045019362,-0.013144299,-0.0074681984,-0.06909997,-0.05109967,0.067076325,0.061704487,-0.03763663,-0.040949136,0.0012587287,0.056641277,0.051944736,-0.04486951,-0.119113415,-0.057880614,0.021064179,0.020371294,-0.027538136,-0.012360693,0.07622564,-0.04207805,-0.022833321,-0.06914304,-0.10760966,-0.054371823,0.015668234,0.04799057,0.012763822,-0.08555607,-0.002396686,0.013050427,-0.040509168,-1.6148332e-33,0.12478227,-0.08368263,0.06287206,-0.11124622,-0.056595173,0.0878301,0.018347032,0.029278623,-0.030828826,0.04604354,0.14742833,0.07318335,-0.023266334,-0.047648646,0.052097294,0.049733188,0.024860552,0.042079933,0.0017035698,-0.015114456,0.045167763,-0.0013647368,0.026103487,-0.032604683,0.080135815,0.077570595,-0.044034243,0.04152797,0.01925787,-0.01090932,0.025084088,-0.020192109,-0.009543403,-0.02485033,-0.079161845,0.033871893,-0.0810428,0.009731447,0.034025256,0.027261252,0.035179883,0.034737155,0.01571749,0.031897362,-0.0033727114,-0.020225992,-0.011201714,-0.01081996,0.0129072415,-0.036747675,-0.009421358,-0.04585626,-0.030858388,-0.02202937,0.032292496,0.04691846,-0.052100196,0.022134468,-0.008066368,-0.0921795,-0.08313657,0.04383576,-0.011598309,0.0069129844,0.07010953,0.01953408,-0.040261757,0.06635354,-0.009937165,-0.06593188,0.030676723,0.005063254,0.0484982,0.045951754,-0.037956722,-0.025893735,-0.10189851,-0.057599664,-0.0071292147,0.041681822,-0.028798666,0.0007134545,-0.061548684,-0.054816548,-0.08836439,-0.09739125,0.020706419,0.037193727,0.028587567,0.06340949,-0.042396564,-0.06242902,0.015736599,0.04538397,0.1071737,-4.192554e-08,0.04736602,-0.078195,0.076546445,0.020033782,0.03067302,0.00064774224,-0.006284338,0.04770036,0.051182833,-0.0011913092,0.006702571,0.06846944,0.037356824,0.04977935,-0.019468054,0.018652735,-0.04296743,-0.05232988,-0.03106433,-0.029892592,-0.105845325,-0.031840406,-0.050662253,0.084048055,-0.0045192977,-0.077816576,0.0012970193,0.10139585,-0.05683127,-0.065210834,0.009746274,0.022068173,0.011953209,-0.00091892964,-0.02735046,-0.011676678,-0.057423253,-0.036049206,-0.039737996,0.069653295,0.0541612,-0.029975258,-0.12728912,0.0009786658,0.041427378,0.029612971,-0.07307121,0.056626886,-0.066822544,0.012614912,0.008601796,-0.0035663433,0.012930671,0.0140032945,-0.014374132,0.004309641,-0.008880937,-0.08657192,-0.021462874,-0.05276693,-0.009823805,0.038552392,0.1964494,-0.05743028 +4.2.1.151,"The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.",384,1.0,-0.036374237,-0.00533791,-0.15641314,0.0013402831,-0.019513471,0.021820175,-0.09373021,-0.009748817,0.07885712,0.018641893,0.023650894,-0.075554274,-0.090793625,0.017597493,-0.0328256,0.02298524,-0.11597564,-0.0042005046,0.05042183,-0.026620518,0.10464261,0.027761038,-0.019610927,-0.10594998,0.01961221,0.00762793,-0.012553173,0.05281027,-0.008717704,-0.019743849,0.015747013,-0.003456542,0.08784059,-0.052497733,0.04750175,0.0945993,-0.03940232,-0.07293196,0.120428585,0.028633097,-0.02849372,-0.017463194,0.0107001215,0.016741974,0.03481543,0.035610955,0.0142209735,0.011060472,0.07626992,0.065771185,-0.0466045,-0.010718983,-0.03609923,0.026629357,0.08702053,0.0018422512,0.008005069,-0.02744991,-0.005408898,-0.004675853,0.043569382,-0.0010766145,-0.019628422,0.031015975,0.0047264956,-0.046387043,-0.067524716,-0.05652936,0.010256547,-0.004765632,0.03318678,-0.048236553,-8.465253e-06,0.015462485,-0.015800675,0.06826128,-0.01760266,-0.008641864,0.02567767,-0.0051145954,0.030138575,0.048034176,-0.0068979235,0.13460785,0.040834066,-0.008139715,-0.019329447,-0.035171222,-0.00053376483,0.1074292,0.016423665,-0.01740466,0.003090491,-0.07170386,0.025935069,0.0015315181,-0.019523993,0.07213108,0.001070184,-0.06671288,-0.00842378,-0.024018623,-0.04267254,-0.08304051,-0.037456658,0.021205928,0.019359406,0.09824562,0.050896917,-0.025252424,-0.10622729,0.053400367,0.021785047,-0.03198279,0.039754618,0.05880549,0.06382148,-0.024912044,-0.044583317,0.03674526,-0.03370153,0.019204408,0.05883553,0.096007325,-0.007792356,-0.0076194364,-0.083479464,-7.6218787e-34,0.04165163,0.029134167,-0.0041731037,-0.026088145,0.03391657,-0.0257183,0.011398113,-0.098882146,-0.06792482,-0.039611388,-0.08836007,-0.040287253,-0.03775201,-0.009585722,-0.017076932,0.0042150654,0.01795154,-0.042262044,0.058038536,-0.045983568,0.001148322,0.013456886,0.0023569504,-0.09464158,0.03801537,0.033719182,-0.011454224,0.03978539,0.024761649,-0.0051341504,-0.054498684,-0.052515462,-0.098273315,-0.050212882,0.04356936,-0.0063872975,-0.05393636,-0.05180989,-0.06780367,0.06072089,0.03509709,0.035006467,-0.04984228,-0.00078343216,0.06562416,0.023450458,-0.06528905,0.09951232,0.12088764,-0.00032731032,0.008388426,0.014453836,0.13356186,-0.060787126,-0.07333108,-0.020562064,0.018000457,0.041237213,-0.031069206,0.08206476,-0.009480855,0.022481453,0.007861,0.07018384,0.0050981124,0.015067043,-0.021326734,-0.0347667,0.04390994,0.088150315,-0.051660214,-0.023982745,0.036596227,-0.02148927,0.050275885,-0.03281455,-0.106406115,-0.05390991,0.022657774,-0.08441611,0.007396353,-0.100081705,-0.04974685,-0.024264023,-0.027510822,0.013875245,-0.041435413,-0.06913727,-0.006501613,0.022211408,0.05490657,-0.11430515,-0.043736596,0.038616974,0.044101294,-1.707961e-33,-0.01542141,-0.08676106,0.023897074,-0.07963595,-0.08448392,0.06366891,-0.03433283,-0.012857174,0.016001059,0.07489076,0.027991174,-0.05903932,0.059020612,-0.0462325,-0.072554514,0.0018481731,0.019113518,0.06601565,0.016543543,-0.027447859,0.017265767,0.052187864,0.06662493,-0.035312835,-0.0068926867,0.070771545,-0.006486853,0.04577496,0.026371233,0.06717882,-0.023347536,0.058772273,-0.09471731,-0.08719771,0.03660082,-0.008120916,-0.02976782,0.040168323,0.11824656,-0.012270355,0.046791673,0.06381062,0.036154225,0.056865104,0.04939143,0.08331877,-0.039154686,0.06853987,-0.064209744,-0.041186944,-0.021592658,-0.007822191,-0.052291747,0.046528913,0.021699544,0.038015418,0.017437171,-0.038645282,0.024650857,-0.018600916,-0.111692384,-0.067181334,0.025292154,-0.033796873,0.037003554,0.07695198,0.015824422,0.07447701,0.04888107,0.011173063,0.08506431,-0.017036287,0.019607933,0.06652541,-0.058999017,0.034986615,-0.03967869,-0.058261044,0.04017732,0.03518037,-0.023497157,0.0058888113,0.0101888925,-0.0055839745,-0.06490255,-0.1179797,0.07120262,0.07971842,-0.046266586,0.08107194,-0.011154692,0.0040809857,-0.07248692,0.022625454,-0.009268138,-2.4795e-08,0.017203385,-0.055374883,0.04684519,-0.020862447,0.06764177,0.016695566,-0.08750664,0.07162298,0.07489777,-0.01019552,-0.072624676,0.057320476,0.009882269,-0.010635802,0.0016915188,0.053453494,-0.0021566548,-0.033555157,0.015224335,-0.06162863,-0.047008008,0.0069484217,-0.083262354,0.047181435,0.006577375,-0.06278926,-0.01829299,0.043385852,-0.010476297,0.0020891866,-0.01887457,0.04558566,-0.036145516,-0.02979735,-0.10448845,0.046950236,-0.037607983,-0.06748731,-0.009383213,-0.04706762,0.013298197,-0.034156997,0.014765757,0.02351465,0.002285096,0.019124102,0.0120673,0.083128035,-0.035556152,-0.033498634,0.019980982,-0.036350187,0.01499342,0.0042919065,-0.10945416,-0.0024530524,-0.041775785,-0.039906297,0.011446246,-0.05388059,-0.045855854,0.010842565,0.18462971,-0.05821953 +4.3.1.30,"The enzyme, which is a member of the 'AdoMet radical' (radical SAM) family, is involved in biosynthesis of TDP-alpha-D-desosamine. The reaction starts by the transfer of an electron from the reduced form of the enzyme's [4Fe-4S] cluster to S-adenosyl-L-methionine, spliting it into methionine and the radical 5-deoxyadenosin-5'-yl, which attacks the sugar substrate. 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+4.6.1.16,The enzyme catalyses the final stage in the maturation of tRNA molecules.,384,1.0,-0.027365288,-0.07725942,-0.118089475,-0.04576172,-0.008461073,-0.032510053,-0.029994762,-0.017924404,-0.029669683,0.0389544,0.071872726,-0.039160166,-0.07560799,-0.0032966544,-0.030196238,0.046000317,-0.14784886,-0.06966351,0.006555812,-0.034488156,0.065047145,0.056598622,-0.09158738,0.009703957,0.009258361,0.022734156,0.06960329,-0.08783509,0.015107973,-0.045404065,-0.056361087,-0.017843537,0.044450946,-0.03718641,-0.008600726,0.059702594,-0.13229914,-0.029017605,0.09498172,-0.00093207957,0.03705246,-0.017297888,-0.036807775,-0.021306433,-0.031243067,-0.090824574,0.10405916,0.036233976,-0.016925246,0.023799328,-0.009765289,-0.062085096,-0.027166981,0.031693626,-0.018508788,0.09366116,-0.05145062,0.020632418,-0.0014369856,0.0046649994,-0.0044882395,0.018905923,-0.041863263,-0.03864609,0.107725546,-0.08631815,0.04198735,0.028367154,0.04036912,0.004714189,-0.04949905,0.019372199,-0.0055495617,0.06051917,0.011202618,0.01701134,-0.0011036561,-0.037710473,0.006937909,0.06345505,0.008093641,-0.0223074,0.025857005,0.041913774,0.0031506857,0.04897507,0.00040622664,0.04343053,0.037250437,0.056780063,0.06875882,0.04809163,-0.034009334,-0.016501747,-0.07072541,0.08023599,0.06000304,0.017827401,0.08377697,-0.06835677,-0.010044412,0.007727426,0.01271967,-0.04427245,-0.048455503,0.008576224,0.012699327,0.048909515,-0.008267479,0.046825867,-0.00012910532,0.028442571,0.11913059,0.020218024,0.01667984,0.09192162,-0.006015374,-0.0075227628,0.043877013,0.03320551,-0.032770496,0.081978336,0.051979434,0.080573045,-0.046590462,0.02387412,-0.060804266,-3.129347e-33,0.0050933156,-0.013076572,-0.005365929,0.04489324,0.046986993,-0.056908607,-0.05542168,-0.015178713,-0.10532499,0.02502586,-0.10320665,-0.05510317,-0.0016778606,-0.08683681,0.015505612,0.00080962724,-0.028175846,0.039904088,0.031003084,0.013213353,-0.022746405,0.06082166,-0.01879487,0.018094953,0.024521017,0.07068775,0.0016172937,0.008984757,0.0027085533,-0.022663005,0.05104313,-0.06928851,-0.09024781,-0.016713826,0.090719186,-0.017043777,-0.00090959435,0.023884404,-0.097132295,0.047751456,0.031623226,-0.039710402,0.015254909,-0.01852271,-0.0147646405,-0.010727618,-0.004031488,0.042703114,-0.0017052429,0.048364464,0.03089799,-0.028780324,0.028938143,-0.021759499,-0.060591154,0.019860988,-0.036402885,-0.05960232,0.07859434,0.021114845,-0.004753929,-0.0025276076,-0.061510377,0.06696805,-0.05308509,-0.016201273,-0.055161756,-0.01954151,0.026480336,0.104480125,-0.056356426,-0.041746844,0.0703919,-0.073501915,0.06257737,0.017321197,-0.04735175,-0.033971965,-0.023458568,-0.010185593,-0.008627176,-0.0299113,-0.010234096,-0.030465819,-0.024905134,-0.05046704,-0.0032271266,-0.036929112,-0.017497282,0.07781404,0.008076256,-0.025583854,-0.06713368,0.00072591123,0.02690852,7.862317e-34,0.14031444,-0.12349638,-0.006604052,-0.036722876,-0.094059095,0.048352297,0.00012305153,-0.06313722,-0.014397813,-0.027619492,0.03993188,0.04864843,-0.03372236,0.0031194428,0.023491912,-0.021494051,0.041862193,0.04133461,0.02435893,-0.074937455,0.0071706134,0.06247818,-0.05677633,0.014073677,0.04723324,-0.047432054,0.022988074,0.12029919,0.052518804,0.07056195,-0.01375348,-0.069860235,0.053833093,0.08875438,-0.08432963,0.0665813,-0.004728222,-0.024439799,0.09574131,0.034098852,0.0022782763,-0.035320986,-0.02885273,0.05197786,-0.026537813,0.056546647,0.007325042,0.045448963,-0.03695686,-0.0756512,0.13555916,0.017598152,0.051606845,-0.04513744,0.047498334,0.06579407,-0.0060292734,-0.027793039,0.052370694,0.0047312565,-0.009880592,-0.09072185,-0.020915385,-0.039755214,-0.030350478,-0.006209231,-0.03061326,0.08922748,-0.0018111697,-0.0033056284,0.022798311,0.039983332,-0.02609452,0.055296108,0.021953488,-0.027095119,-0.026915234,-0.028867655,0.061924506,-0.10367872,-0.07875489,0.022918558,0.0059152157,-0.08661323,0.045303427,-0.046703503,0.0009515273,0.093427785,0.02573844,0.0763226,-0.008525516,-0.0147179505,-0.016460657,-0.01846618,0.033069324,-2.0888345e-08,-0.056019183,-0.023562266,0.005130606,-0.006835723,0.054302357,0.1438967,0.04246793,0.038863692,0.076491185,0.0067529026,-0.053168688,0.0037207403,0.01930246,0.07982835,0.026029151,0.060098074,-0.114329085,-0.037138026,-0.027634045,-0.032964267,-0.07992268,0.05459926,-0.16452295,0.024602091,0.0045053246,-0.024296766,-0.026576765,0.101540774,-0.05027903,-0.02856266,0.018544294,-0.010508344,0.048969507,-0.034534436,-0.055598643,0.029842736,0.02702427,-0.05774139,-0.035931017,0.0376192,-0.004968224,-0.016818544,-0.06190615,-0.050391108,-0.09165647,0.02621893,-0.024268078,0.10987164,-0.0035268217,0.025883904,0.10547076,-0.019896185,0.00037494866,-0.0137918545,-0.034975253,-0.023025803,0.0006768981,-0.05799449,-0.065094225,0.015120616,0.021288466,0.037180185,0.11657158,-0.08659996 +5.1.3.28,Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Involved in bacterial polysaccharide biosynthesis.,384,1.0,-0.04829913,-0.06594764,-0.13711205,0.028779449,-0.023181174,0.090485826,-0.078547284,0.025243914,0.050117187,0.028817575,0.059274733,-0.046519447,-0.029356582,0.019813936,-0.087597676,-0.017272204,-0.017099518,0.036997635,0.04430084,0.0254796,0.09089354,0.050939325,-0.080972224,0.007502856,0.047374316,0.01863963,0.050946638,-0.043931935,0.0142763015,0.0004961843,-0.06957955,-0.089351825,0.11708047,-0.07131367,0.09596955,0.081300735,8.163277e-05,0.041846253,0.19342957,-0.00863993,0.023260465,0.006107302,0.068114,-0.09807016,-0.034468967,0.036157973,-0.006341112,0.039636556,0.048929248,-0.051440954,-0.024195636,-0.009917741,-0.020776305,0.039295096,0.06477182,0.016988993,0.0051228018,-0.07001628,0.001083699,0.0068609836,0.022146521,-0.044608206,0.048196446,0.012356457,-0.10964491,-0.0181113,0.008060481,0.02938748,0.07884212,-0.020867197,-0.047231298,0.04394037,0.0521552,0.04860959,0.0100083435,-0.007376994,0.016944183,-0.0625613,-0.03055993,0.010671719,0.039225806,0.005174276,0.014889918,0.096413195,0.02486826,-0.062703826,0.024884071,0.0572069,0.039536987,0.03982949,0.0084909685,0.014304138,0.009171956,-0.07933783,-0.062397446,-0.038451087,0.023645842,0.0007835192,0.08190847,-0.061962802,-0.0068469374,0.004639134,0.07929793,-0.10899893,0.008349385,-0.0011496823,-0.018328656,0.00045702304,0.0753161,0.04409339,-0.0041986727,0.06772492,-0.09985128,-0.083606325,-0.046451066,0.045402806,0.10007949,-0.10722995,-0.054695763,-0.021153701,-0.027272638,-0.049300276,0.12479742,0.027192768,-0.017459244,-0.069059566,-0.056814123,1.5274549e-33,-0.031182105,-0.015955854,0.016426103,-0.050056327,0.07869956,-0.016581414,-0.0007401395,-0.07572597,0.0153626455,-0.045268316,-0.036885228,-0.08297906,0.026230892,0.049076363,0.04209119,0.03704867,0.0023203578,-0.07725535,0.06775253,-0.06577283,-0.00028242025,0.08111002,0.0015936528,-0.011621945,0.045742508,-0.014060023,0.038082454,0.0061657093,0.02623388,-0.006241401,0.019498719,-0.011176203,-0.04636361,-0.03688362,0.110584036,0.018421277,-0.09970743,-0.014629298,0.06525605,0.063669406,0.07069653,0.03555597,0.044733755,-0.019635381,0.03253668,0.019294914,-0.05686728,0.09901587,0.02670538,0.08191311,0.02579268,-0.023693489,-0.03732012,0.05865688,-0.06616816,-0.029503748,-0.018658398,-0.026684353,0.01032622,0.08963191,0.027556853,0.030863086,-0.026360676,-0.003550851,-0.0044313823,-0.0033778222,-0.02581292,-0.00053793256,-0.045603417,-0.016507253,-0.051179253,-0.09081916,-0.024187203,-0.030485239,-0.02264077,-0.012113157,-0.039467033,0.035695292,0.03558688,-0.0051330477,-0.020309063,0.054493763,0.01938743,0.0066416543,-0.09692426,0.037099652,-0.0018866727,0.026223212,-0.028729713,0.004641556,-0.0063075316,-0.13066618,-0.05772522,0.0997313,-0.048147984,-4.5869332e-33,0.071239986,-0.08612199,0.071305126,-0.069546424,-0.040530138,0.056814864,-2.1639691e-05,0.03646536,-0.02584058,0.009818039,0.0383736,0.0123143485,0.0546496,0.020715816,0.0033569827,0.059734035,0.052247748,0.08889101,-0.060318988,0.01897608,0.017155113,0.002438412,0.031435605,-0.05764645,0.05375436,0.02583653,-0.018220538,0.0753875,-0.01435118,0.052713472,0.0028891992,0.020739404,-0.08862768,-0.063096955,-0.08411878,-0.008589718,-0.070826985,-0.0381923,0.069185995,-0.025434256,0.06256863,0.045382146,-0.016767342,0.04399896,0.012973141,0.015824376,-0.0451864,0.013524691,-0.017184833,-0.053155627,-0.009765212,-0.014262262,0.036865246,0.023505202,-0.025420358,-0.014845171,-0.00013939082,0.05073896,-0.010428842,-0.117250666,-0.01963726,-0.052047,0.016899534,-0.04892782,0.028790655,0.054008804,0.0034104523,-0.04353158,-0.021039065,-0.053892374,0.031868543,0.031906854,-0.06583933,0.016860645,-0.080322735,-0.026955977,-0.13051133,-0.0665938,-0.0009857845,0.04638882,0.050925493,-0.023767853,0.027832879,-0.012967139,0.0037521217,-0.02489261,0.081142,0.060334202,-0.014327481,0.02631104,0.016029116,0.038053278,0.00684643,0.079435624,0.031735584,-2.8370435e-08,0.0345881,-0.051238645,0.01967191,-0.0009032641,-0.09314814,-0.009264027,-0.10572972,-0.034652103,-0.044961628,-0.014699642,-0.049270254,-0.0141473785,-0.057371546,0.03365677,-0.008071689,0.014168872,-0.1055218,-0.023138145,0.018393196,-0.039125867,-0.11222116,0.0036839326,-0.070386775,0.04396301,-0.02395589,-0.030209597,0.08322177,-0.078488626,-0.016635817,-0.061260257,-0.0044410387,0.029258817,-0.06326797,-0.082410194,-0.038168352,0.01403853,-0.012283308,-0.086516745,-0.0075861253,-0.013823541,0.04637976,-0.02270109,-0.026687633,0.05968264,-0.013600147,0.030793548,-0.053415105,0.045066435,-0.0052714767,-0.04563479,0.07514975,-0.012624114,0.005647895,-0.027369827,-0.0877695,0.015200845,-0.03251073,-0.052653026,-0.03543363,0.032796036,-0.044130478,-0.010941381,0.12742701,0.0879548 +5.3.1.30,"The enzyme, found in the bacterium Bacillus subtilis, is part of a myo-inositol degradation pathway leading to acetyl-CoA.",384,1.0,-0.11227885,-0.023668239,-0.05606769,0.009598154,0.08273556,-0.057188597,-0.048919715,0.07023697,0.033683375,-0.020653917,0.028435426,-0.07284978,0.011399593,0.060722195,-0.10277835,0.09498176,-0.020520864,0.00025056308,-0.007885654,-0.047358416,0.046967696,0.10879195,-0.06714976,-0.0042292005,0.049675502,-0.03979936,0.054595508,-0.011286899,-0.051790867,-0.08322419,-0.029497992,0.026105853,0.09738512,-0.026069382,0.08981089,0.14556557,0.014905035,-0.06593126,0.15058593,-0.011432908,0.024679735,-0.009012959,-0.0035998186,0.00087085424,0.0002449939,0.003598027,-0.045110133,-0.011097388,0.0547891,0.033883374,-0.08082271,0.009503379,-0.021597408,0.032983743,0.0051361793,0.003888379,-0.024202032,-0.04983502,-0.015013937,0.053808715,0.07308757,-0.010614945,-0.021543391,0.05248253,-0.0173604,-0.052312538,0.05354306,-0.007876936,-0.031457525,0.011595703,-0.042406593,-0.039465133,-0.05287107,0.1542441,0.05170045,-0.021787172,-0.033319674,-0.054069486,0.0441789,-0.030061107,0.010376917,0.032697745,-0.018517504,0.018390825,0.065686695,0.030646432,0.09334727,-0.079688355,0.019860826,0.031422403,0.029566605,-0.074571416,-0.0035039107,-0.08634076,0.00770772,-0.0012840689,0.046361096,-0.041466776,0.027568376,-0.018660527,-0.033379458,0.049900874,-0.02864784,-0.030406658,-0.05970011,-0.010883269,0.025710272,0.08014635,0.08950969,0.07240721,0.0020961347,-0.05404811,0.06362882,-0.07412815,0.037355747,0.09707812,0.015514024,0.0005166991,-0.056709316,0.05585004,-0.028838404,-0.02555215,-0.01467299,0.070133105,-0.05297294,0.050543457,-0.029460723,-4.395124e-34,0.020443162,-0.019729009,0.012445666,0.023190726,0.027562743,-0.12390339,-0.081915304,-0.024239643,-0.06700829,-0.08004129,-0.02795599,-0.09665119,-0.02370976,0.071162604,-0.038233187,0.05725341,0.012178398,-0.033006717,0.039586034,0.022255642,-0.068850994,-0.00017104259,-0.0153357135,0.0059824316,0.013408621,0.058893487,-0.008128049,0.02479822,0.041608293,-0.003494643,0.060476344,0.007166473,-0.115829416,-0.0155728655,-0.011241227,-0.03428475,-0.04127056,-0.03636289,-0.043316722,0.09098842,0.02087585,0.0702987,-0.010714388,-0.010916954,0.023414508,-0.07417216,-0.016598305,0.06735906,0.004018002,-0.0031036048,0.019676298,0.0067937034,0.09633018,-0.0553605,-0.019318417,0.022555947,0.006734381,0.0010682743,0.028690433,0.019776953,0.03497441,0.062234584,-0.026600184,0.12210966,-0.07479683,0.012942244,-0.067825615,-0.019974373,0.047610674,0.028042616,-0.036564324,0.00045295802,-0.022993194,0.022887226,-0.005945811,-0.029473674,-0.059472077,-0.0022348177,0.006604607,-0.04666329,0.014794643,-0.03132725,0.02571949,0.004093478,-0.017028093,0.01941423,0.027941858,-0.08272224,-0.0011424725,0.036190998,0.043796975,-0.07462994,-0.055120654,0.04641039,0.0022193836,-1.876141e-33,0.11799807,-0.12674241,0.09758811,-0.13900946,-0.13067916,0.020309513,0.004364512,0.0127912965,0.034306236,0.069744594,0.06332442,0.011989132,-0.022584308,-0.02138782,0.034310807,0.020300465,0.022531265,-0.005776834,-0.018831246,-0.015113321,-0.013216867,0.11019611,0.070745885,-0.080553606,0.04462556,0.026470076,-0.066139325,0.06798919,0.021181775,-0.0019417837,-0.018683145,-0.011533394,-0.03568803,-0.066637754,-0.06134759,0.0507182,-0.05239922,-0.015308608,-0.007967101,-0.06562255,-0.026907006,0.077513896,-0.00021616003,-0.010560037,0.00070696214,0.0038800722,-0.04378568,0.0147757055,-0.014570072,-0.105022945,-0.023273649,0.009100338,0.029715795,-0.016037934,-0.0039034255,0.06511708,-0.03169362,0.040050633,-0.0025362668,-0.0856954,-0.06901602,-0.027691962,0.014531556,0.0031077408,0.08234975,0.1160309,-0.009665094,0.07512139,0.017943917,-0.0866812,0.034086686,-0.0124178445,0.0335654,0.043413952,-0.0081889285,-0.06323567,-0.085213974,-0.005170188,-0.00044443473,-0.018025404,-0.09660984,-0.028970055,-0.10012571,-0.037350375,-0.082176134,-0.098223425,-0.00075130415,0.107598245,0.0026764548,0.022567457,-0.009925905,0.03917303,-0.059512053,-0.0082748,0.009552039,-2.6955515e-08,0.06572038,-0.06838127,0.052609716,-0.033191226,0.061488435,-0.0058919345,-0.017889736,0.039199647,0.0880102,0.01935624,-0.065834,0.10620784,0.055175107,-0.042008456,0.000448386,0.025146913,-0.03891238,-0.047510512,0.02109231,-0.045203328,-0.0634142,0.0019357869,0.013854893,0.06298975,0.022445565,-0.060338315,0.06984238,0.07739704,-0.041010328,-0.028510997,-0.042983744,0.06562249,0.008746181,-0.018670868,-0.046030458,0.031208174,-0.0620293,-0.017718587,-0.01350464,0.0511371,0.057888348,-0.00043643283,-0.056369975,0.0050837523,0.03552202,0.07151639,0.013099342,0.025480198,0.035506472,-0.034987777,-0.044912387,0.003532323,-0.029322447,0.034258872,-0.05538685,-0.024696467,-0.0074283173,-0.018126864,0.035938658,-0.020018183,0.01885317,0.0013625395,0.12465765,-0.059427604 +5.3.99.11,"Requires a divalent metal ion for activity. Mn2+, Fe2+ and Co2+ can be used. The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.",384,1.0,-0.07129741,-0.07306016,-0.044579167,0.045201845,0.08078083,-0.03269027,-0.024968335,0.051451337,-0.009105205,-0.0032516473,0.036169913,-0.078240104,0.033350233,0.09333324,-0.052113585,0.03939345,-0.033123493,0.007157533,0.013294778,0.013049885,0.057351936,0.08874806,-0.047524907,-0.056689095,0.01680092,0.030160993,0.05495719,-0.057089895,-0.020613218,-0.043953456,-0.032945286,0.030066712,0.11785763,-0.07380021,0.028135896,0.116620205,0.0058089923,0.01481476,0.08362988,-0.0062516816,-0.027018644,-0.016454197,0.06765554,-0.005431391,-0.0068380926,-0.068438634,0.05761304,-0.0774532,0.053625617,0.050006803,-0.06479357,0.026650691,0.0002476116,0.06568224,-0.0062263226,-0.013980591,-0.049662296,-0.043133292,-0.016847448,0.0051225238,0.06082477,-0.027604582,0.019472448,0.0024406414,0.005131344,-0.045246895,0.017417153,-0.018106446,-0.014133142,0.015654795,0.010950271,-0.033928018,-0.0667423,0.057896186,0.0175201,0.02628987,0.08949466,-0.11484513,0.08870486,-0.0026201447,-0.06371116,0.035386123,0.03765549,0.06757678,0.088692375,0.123405725,0.05965318,-0.04872059,-0.020200469,0.036323972,0.039847106,0.013081299,-0.003766751,-0.08564619,-0.013130563,0.0026015027,0.015732203,0.0015910534,0.050736763,0.024164792,-0.016271727,0.077064656,-0.07410693,-0.017088428,-0.01387369,-0.047664247,0.050032575,0.09249574,0.057457156,0.07256923,0.06538917,-0.0046295994,0.019779157,-0.054765776,0.043758404,0.065537624,0.067656405,-0.06139301,-0.05212232,0.017552594,0.027458508,-0.024680326,-0.061986774,0.06546112,-0.04634266,0.042111937,-0.042101484,2.392386e-33,0.020845724,0.013117796,0.0316528,0.019979026,-0.033340663,-0.047208354,-0.07057027,-0.037657555,-0.0022615173,-0.08934638,-0.06663005,-0.07118379,0.01579953,0.07478617,-0.03643801,-0.006814358,0.00971301,-0.057690162,0.11311725,-0.003221381,-0.025480961,0.011207157,0.027603183,0.039935995,0.051208183,0.053708103,0.08410584,-0.009166693,0.049218003,-0.011219942,0.0842509,-0.06027355,-0.083160974,-0.0046618693,0.023087455,-0.013573161,-0.08556623,0.015884036,-0.046939876,0.03249244,0.039103255,0.1100675,-0.07793718,0.028113596,0.047973953,-0.098432735,-0.018142369,0.11430496,-0.03056931,0.013994878,0.028385468,0.06195307,0.047641434,-0.062206067,-0.036866974,0.0419782,0.012158027,0.011568903,0.04566346,0.045586165,-0.025553634,0.029641345,0.029572956,0.15488781,-0.0049641766,0.010233322,-0.050329816,-0.04554199,0.020962441,-0.0066147246,-0.056631792,-0.051593605,0.024544578,0.03136433,-0.060853973,-0.022270074,-0.065350465,-0.06196607,0.06154598,-0.034665022,0.013907859,-0.06704193,0.017531108,0.0014928238,-0.06410786,-0.005040618,-0.023914974,-0.09807849,0.00621276,0.012695268,0.029338142,-0.034642708,-0.06317522,0.011343932,-0.024177138,-3.9134473e-33,0.081792474,-0.076759204,0.1055258,-0.12969366,-0.1425725,0.03528619,0.002546626,-0.1136643,0.05541646,0.054311253,0.040774178,0.008275432,0.01188897,-0.05453953,0.004468328,0.045846447,-0.009798851,0.046145882,0.032495387,0.012609352,-0.03400009,0.11920154,0.050209396,-0.044937145,0.06185147,0.037851047,-0.064388156,0.011262413,0.009759751,-0.006444816,-0.018074647,-0.027632164,-0.015050813,-0.12410586,-0.060584057,0.046244398,-0.0060906745,-0.044426013,0.007854993,-0.03550403,-0.041260485,0.02684341,0.019884808,0.06576821,-0.061952237,-0.015897451,-0.05176613,-0.0036698275,-0.013991336,-0.04904706,-0.015297443,-0.051791623,-0.066840425,-0.07204545,0.04451754,0.0414062,0.0023950895,0.05057853,0.0059086415,-0.06428479,-0.046904795,-0.0369309,0.030578379,-0.028521301,0.03296153,0.09832202,0.008324401,0.065804966,-0.011535056,-0.07378184,0.027613439,0.06263745,0.092443004,0.007528386,-0.014896708,-0.056019377,-0.053586602,-0.0131544685,-0.015504063,-0.014043273,-0.06636674,0.0104339635,-0.072584584,-0.048004773,-0.030801196,-0.08974272,0.021478895,0.11068561,-0.059699144,-0.003106145,-0.06174249,-0.01731107,-0.019016067,0.00718664,0.024284506,-3.8271345e-08,-0.005400118,-0.068969734,0.049540088,-0.107073806,-0.00915494,0.024165906,-0.019585343,-0.04240069,0.075072795,-0.0122825615,-0.0065796226,0.09795334,0.0445214,-0.034447875,0.0478099,-0.014807868,-0.0059088613,-0.01239891,-0.05212696,-0.05456486,-0.06461198,0.012915057,-0.053634644,0.042736165,0.016959494,-0.04747916,0.03897395,0.05333849,-0.060521692,-0.021786828,-0.03620262,0.06008705,-0.002278542,-0.034450334,-0.037501957,0.025062881,-0.038808018,-0.031321503,-0.041786123,0.039509363,-0.009189628,0.018790634,-0.05636966,0.017487964,-0.02103535,0.030180091,-0.08720097,0.10652027,0.00570958,-0.023516817,-0.004751047,-0.047274653,-0.028527394,-0.007081456,-0.057160106,0.08243865,0.022403762,-0.06294303,0.012262439,0.0025472138,0.01665549,-0.023750283,0.080341734,-0.103426486 +5.4.1.3,"The enzyme, purified from the bacterium Chloroflexus aurantiacus, acts as an intramolecular CoA transferase and does not transfer CoA to free mesaconate. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.",384,0.99999994,-0.08873736,-0.07221552,-0.07690949,-0.0399979,0.07058226,0.032178964,0.008601753,-0.022730766,0.013923319,-0.028828127,0.01751935,-0.12898028,-0.009388407,0.039970804,-0.07924041,-0.022617294,-0.04100997,-0.021768669,0.017050138,-0.028460057,0.04708829,0.0018320568,-0.069604486,0.015327815,0.07888894,0.018926028,-0.0032450287,-0.103316315,0.044684127,-0.05628614,-0.04137475,0.040826768,0.019700376,-0.04334889,0.06828787,0.1106904,-0.002183993,-0.11385428,0.020782534,0.031009598,0.04752183,-0.001072714,-0.02054456,0.018464955,-0.06403121,0.025458653,0.0567724,0.01260143,0.026203219,-0.0137385335,-0.06021814,-0.066317014,-0.12293857,0.056563348,-0.07457981,0.0868054,0.03944999,-0.010396745,0.019964708,0.013988103,-0.019528871,0.052775387,0.011654702,0.07739387,0.042821024,-0.088458136,-0.002441925,-0.018317252,-0.049254283,-0.092575155,-0.018072492,-0.03890055,-0.08365224,0.008597489,0.0557739,-0.005620029,0.030525401,-0.017625244,-0.014401236,0.008376702,-0.009673154,0.016728936,0.029036038,0.052931078,-0.036712576,0.019138714,-0.0141337365,-0.029618444,0.015925875,-0.05563797,0.013851834,0.022832355,0.0049762507,-0.05247602,-0.08451972,0.054058664,0.043984488,0.042257838,0.091242895,-0.035130166,0.0071253837,0.015379757,-0.016318182,-0.050207596,-0.06939979,-0.009614707,-0.00940251,0.0954148,0.019363688,0.0019328947,-0.053081308,0.052921984,0.061862342,0.032585718,0.07734721,0.061354764,0.035533752,-0.056530517,-0.06073412,0.06729698,-0.0054244827,-0.04742348,0.07621675,0.0715988,-0.0023996518,0.11517884,-0.020156622,3.4611076e-33,0.015937591,-0.0096355025,0.04726222,-0.044843614,-0.03137142,-0.019577341,-0.053330027,-0.068389446,-0.08446133,-0.06997158,-0.025101217,-0.004673004,-0.0034092101,0.065544836,0.004868171,0.0021432738,-0.0045033908,-0.035288967,0.0912392,0.047391154,0.012660658,0.067595124,-0.053651605,0.036724973,0.033084236,0.013042662,0.008233871,0.057833426,0.061536536,-0.011648311,0.022044834,-0.05549912,-0.09083479,-0.03051026,0.027974807,0.002327455,-0.0263166,-0.005237105,-0.077871256,0.035656102,0.02425657,0.026694216,-0.037407946,-0.027357783,0.087311685,-0.09790737,-0.05647209,0.011728212,0.0067531047,0.016182093,-0.01627465,-0.0004926799,0.10517688,-0.061460756,-0.031503696,0.08338907,0.029140275,0.0041768816,-0.013921668,0.0066980827,0.031401817,0.06404936,-0.051252376,0.04566271,0.011858407,0.076397896,-0.055621058,-0.013164619,0.04962836,-0.0046499083,-0.14232136,0.015641648,-0.0310276,0.062332727,0.06463669,-0.10924047,-0.054180495,-0.033958506,0.038601376,-0.07533181,-0.006921796,-0.013035918,0.08188403,0.022582231,-0.0030263544,-0.035881214,0.010028537,-0.014792972,-0.048682142,0.041308478,0.14506088,-0.049540855,-0.05942742,0.015500731,-0.019081285,-3.600382e-33,0.1249109,-0.12709844,0.013440994,-0.08266288,-0.05870123,0.011923047,0.022771912,0.035947584,0.04937577,-0.017883867,0.07401433,0.04381967,-0.054303106,-0.012423165,0.015376516,-0.011502606,0.071805835,0.023523957,-0.08080729,-0.010136799,0.009468835,0.026723947,0.074401535,-0.032940045,-0.014312603,0.0036015713,-0.044548657,0.10679447,0.06028327,0.0070860023,-0.041100368,0.0051193233,-0.035582874,-0.06471841,-0.08566474,-0.0040482734,-0.006113338,0.018877853,-0.00040572515,0.013058561,-0.040396623,-0.00093448244,-0.024334775,0.01025229,0.02047173,0.092996225,-0.060777843,-0.024014894,-0.018350763,0.008320804,-0.010749783,-0.006284745,-0.019516747,0.05492092,0.05688955,-0.019442776,0.10808144,0.07131693,0.03432421,-0.113582626,-0.046472277,0.021841936,-0.015289426,-0.06595614,0.13298303,0.083984315,-0.005614758,0.08413561,0.059404414,-0.041293982,0.099044494,0.01667174,-0.00067001616,-0.020901298,-0.02320594,-0.002439167,-0.06496304,-0.024022082,-0.017771168,-0.06376303,-0.032734767,0.015597419,-0.038036834,-0.0593378,0.011993167,-0.11640579,0.013977107,-0.016420769,-0.0146955475,0.04990647,-0.027298862,-0.032676857,0.0054864665,0.019471906,0.09637903,-3.4284955e-08,-0.019540343,0.018953523,0.008250747,-0.007028705,0.005883932,0.015452347,0.0029904458,-0.04405809,0.09431439,0.026660988,-0.05489608,0.068302095,0.092277415,0.018626586,-0.006712445,0.015408017,0.013749248,-0.06455398,-0.0028807279,-0.055174287,-0.07062263,-0.004506664,-0.07869466,0.089782104,0.011523867,-0.060249932,0.047073316,0.044359926,0.008488323,0.0034378853,-0.06263712,0.06634304,0.015007768,-0.0015484919,-0.0038724167,0.02014223,-0.028472103,-0.014611184,-0.016801363,0.03236564,0.052577354,0.031155331,-0.061738446,-0.045008495,0.06319723,0.020604188,0.016165722,-0.0074174805,0.05934438,-0.0053887563,0.063371755,-0.030705782,-0.036804274,-0.023041597,-0.06612835,-0.020398814,0.026381696,-0.09379099,0.022135647,-0.018635547,-0.010111744,0.0055755475,0.18939584,-0.070278175 +5.4.99.60,"The enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of cobalt-precorrin-8 to cobyrinate by methyl rearrangement. The equivalent enzyme in the aerobic pathway is EC 5.4.99.61, precorrin-8X methylmutase.",384,1.0,-0.035497915,0.049233656,-0.103956565,0.03163453,0.07287381,0.077949986,-0.086386524,-0.0076840194,0.019099686,-0.018065484,-0.005211591,-0.0629847,-0.088734075,-0.028607113,-0.026454607,0.039397884,-0.06083185,-0.02537456,-0.050780103,-0.028453836,0.034181163,0.0014495958,-0.004712398,0.076248646,0.03428424,-0.016962528,0.03423573,0.009079763,-0.021516839,0.014780942,-0.021192355,0.0014842418,0.052116867,-0.0087390775,-0.00592694,0.123788975,0.033021193,-0.029268151,0.040073037,0.040275514,0.004793381,0.033722844,-0.0054865545,0.007938963,-0.014348928,-0.01255555,0.048866313,0.02478973,0.00965079,-0.021116355,-0.029738562,-0.03305089,-0.076788515,-0.034679595,0.014684344,0.07506959,-0.05336494,-0.087283626,0.05123837,0.017312894,0.034992427,-0.07667254,-0.0041712574,0.053101644,0.015140926,-0.02744321,0.05765411,-0.038079508,0.03794396,-0.054099057,-0.024686728,-0.07559082,-0.04789799,-0.0001914398,-0.062297106,0.0756454,0.03279327,-0.06713678,0.04684881,-0.022695389,-0.021821065,0.038890056,0.029022327,0.008662062,0.06635459,0.0020794037,-0.0054281233,-0.011178776,0.023263086,0.06376302,-0.04552856,-0.019757636,0.033253025,-0.02465954,-0.122670494,-0.022982696,0.056147233,0.035186302,0.04028524,-0.01877158,0.048929065,0.10505753,-0.050999314,-0.016352281,0.02068344,-0.044769198,0.08516614,0.1392071,0.04404499,0.055606242,-0.028258624,0.089559734,0.008599425,0.020840984,0.016410194,0.13585334,0.018720023,-0.054083873,-0.10577069,0.07651427,-0.021540502,-0.040376145,-0.005975065,0.027478522,-0.060545396,-0.06415692,-0.0058265966,2.2322441e-33,0.05623323,0.026939727,0.009927969,-0.011636951,-0.0099944165,-0.004897503,-0.13009328,0.024961378,0.03495649,-0.031366788,0.0005251995,-0.031097708,0.04089745,0.016558457,-0.08378008,-0.11261533,-0.05609145,-0.029853841,0.032634903,-0.004890687,-0.04495302,0.060518645,-0.049620822,0.009628999,0.008538076,0.043043885,-0.03677669,0.05278329,0.081453435,-0.009355271,0.024670118,-0.08462741,-0.11122443,-0.055079542,-0.0016084164,-0.01693368,-0.044102795,-0.0020659205,0.03940147,0.07134732,0.015997883,0.03519164,-0.06427771,-0.05429819,0.04462857,-0.071086764,-0.047901068,0.09633721,0.047217563,0.033449285,-0.028611494,0.023343857,0.11657103,0.002726501,-0.048398405,-0.004569666,0.015952406,-0.026816266,0.00012898949,0.06138942,0.07057223,0.035791237,-0.015048626,0.05810064,-0.0045642015,-0.035659723,-0.04052893,-0.057410866,0.04048736,0.036398802,-0.025688889,-0.047601182,0.023230372,0.07127502,0.025276657,-0.024314905,-0.07837224,-0.05125855,-0.037363708,-0.035144594,-0.018320944,0.033734445,0.03930676,-0.051252317,-0.06456249,0.03838655,-0.0043388894,-0.045458656,-0.012727547,-0.038957693,0.009519021,-0.025345596,-0.011330702,-0.0050839335,0.045563687,-3.182291e-33,0.11460628,-0.08206043,0.09154896,-0.14849836,-0.021576434,0.08644466,0.06801559,-0.09607181,-0.032962013,-0.012679691,0.051817805,-0.010521882,0.056005087,-0.029410357,0.029954016,-0.016591465,-0.01948849,0.08303652,0.0012284004,-0.008168694,-0.0018715998,0.036171813,0.008248317,0.0210812,0.029528132,0.03138954,0.016663127,0.05788669,0.07122683,0.034158405,-0.04896267,0.012165896,-0.01674539,0.019383967,0.00249688,0.079151414,-0.030076137,0.030350156,-0.03213595,-0.01540925,0.014941679,-0.016766556,-0.04490426,0.0577477,0.02018696,0.066271156,-0.07575792,0.025640875,-0.025130708,0.0009074867,0.04092674,0.041275796,-0.08862337,0.020945081,0.10941093,0.036527287,0.0494672,-0.07562115,0.02928377,-0.12442334,-0.09266393,0.024853183,0.043702137,-0.08330422,0.028082412,0.02090568,0.0005031388,0.05799559,0.019232154,0.0142770475,0.06272566,0.08294621,0.021260759,-0.0052032033,-0.07565772,-0.022093024,0.030946856,-0.035842758,-0.033588633,-0.09046651,-0.0793932,-0.012006619,0.087736994,-0.04782719,-0.10398182,-0.03087408,0.06621621,0.012965849,-0.042447902,0.060256235,-0.03339293,-0.05584287,-0.022068316,-0.03106123,0.023588546,-3.34722e-08,-0.0035079878,-0.08178287,0.10871943,-0.00015727966,-0.00026574504,0.10930418,-0.007968065,-0.048422378,0.05350714,-0.010637633,0.026781077,0.091828994,0.09727186,-0.010750189,-0.085106894,-0.028679611,-0.052696433,0.032154206,0.017703343,0.019839415,-0.08339168,0.011387024,-0.015498744,0.00314031,0.0679005,-0.07630317,-0.06923046,0.098121494,0.017330078,-0.027811788,-0.009102189,0.029678212,0.05534465,-0.037163127,-0.025519565,0.015578073,-0.0013059066,0.020127006,-0.10173337,-0.023455404,-0.027844157,-0.07120669,-0.07057132,0.024201872,0.024903936,-0.033294976,0.0071055763,0.054399576,-0.0026317453,-0.019661551,0.042796757,-0.04486941,0.005959795,-0.017001377,-0.048181992,0.02293666,-0.07371465,-0.09516687,-0.0544231,0.021471392,0.008851107,0.013677155,0.09690232,-0.12982534 +5.4.99.61,"The enzyme, which participates in the aerobic (late cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of precorrin-8X to hydrogenobyrinate by methyl rearrangement. The equivalent enzyme in the anaerobic pathway is EC 5.4.99.60, cobalt-precorrin-8 methylmutase.",384,0.99999994,-0.031324733,0.06649411,-0.098474964,0.016755179,0.04911236,0.101522654,-0.08172305,-0.00090232154,0.010030561,0.030420993,-0.015858572,-0.075627096,-0.109020025,-0.022866005,-0.00026550304,0.070885345,-0.06363291,-0.0070486357,-0.054193523,-0.010709662,0.017532187,-0.015144485,0.011641365,0.06624569,0.049776826,-0.032218937,0.04372999,0.043283124,-0.058275588,-0.009618767,-0.011571446,0.001072162,0.059378285,-0.042750146,0.019877328,0.1356451,-0.0013284956,-0.046440907,0.07061319,0.015102611,0.0615571,0.010777864,-0.013139322,0.011824817,-0.01902262,-0.014259946,0.06619549,0.028323613,0.019822532,-0.039999444,-0.022352597,-0.044341266,-0.08403696,-0.018586766,0.012890496,0.0777842,-0.0217677,-0.05652365,0.046652026,-0.0062770746,0.023863323,-0.0574103,0.0001997933,0.021010058,0.0020439983,-0.06016043,0.06372451,-0.07975541,0.043626,-0.051454134,-0.05244257,-0.06426904,-0.03407908,0.025441121,-0.04178272,0.04584314,0.04270536,-0.031806957,0.041998796,-0.04150905,-0.041659955,0.03511334,0.019838354,0.007819472,0.042758055,-0.011878072,0.004560646,-0.033997424,0.03699192,0.038497735,-0.03315984,-0.02057049,0.039623894,-0.066298425,-0.12187063,-0.026500333,0.039877523,0.029128686,0.063199334,-0.007888227,0.08220768,0.089067,-0.08759056,-0.028161012,0.02627506,-0.018776214,0.056874454,0.13121757,0.026604889,0.027064834,-0.03410199,0.09939688,0.017490001,0.040729303,0.020614665,0.09173412,0.026793579,-0.040116902,-0.07635371,0.09454513,-0.032679573,-0.052746408,0.05160966,0.04105784,-0.043323245,-0.08043374,-0.05425756,2.7244833e-33,0.06703121,0.008219202,0.023982355,-0.02507854,-0.015473796,0.0009831812,-0.11396549,0.021844126,0.032501347,-0.03380344,-0.018034564,-0.034180988,0.061992753,0.025518078,-0.10895553,-0.09697519,-0.08112873,-0.010337482,0.008951913,-0.004399185,-0.07623191,0.02025782,-0.03936407,-0.0012446671,-0.0011615774,0.07136927,-0.019246902,0.027984748,0.09150862,-8.9646375e-05,0.0135586085,-0.07420799,-0.12771869,-0.049200404,-0.0051005064,-0.0020817756,-0.0088786995,0.010762322,0.03995413,0.065534174,0.014123454,0.04393515,-0.049927555,-0.07096459,0.073312216,-0.043210972,-0.040148858,0.09921975,0.064076625,0.03703757,-0.0026941213,-0.042546622,0.121889025,-0.008296074,-0.044324603,-0.0068908436,0.021462237,0.013122976,0.009010575,0.07381705,0.073925965,0.05733703,-0.035550468,0.076688915,-0.014403848,-0.051969294,-0.025862342,-0.060508788,0.043674767,0.03074264,-0.029466901,-0.036888022,0.055297725,0.07367861,-0.01378418,-0.011694574,-0.10434364,-0.0562154,-0.012235272,-0.039746836,-0.025648395,0.031788573,0.038147997,-0.07704156,-0.03346246,0.04350397,-0.017978903,-0.067511216,-0.031233981,-0.009648035,0.043665454,-0.033308435,-0.034407448,-0.028218506,0.033688217,-3.1478556e-33,0.12438412,-0.048059013,0.04288023,-0.12221044,0.02507006,0.045286592,0.09156331,-0.06442474,-0.03742609,-0.044736296,0.061854027,-0.030692182,0.070325665,-0.025545241,0.048657607,-0.036859058,-0.008109652,0.06910416,0.0012172791,0.0053799665,-0.018502759,0.012506127,0.007615859,0.013635557,0.029923014,-0.00068454153,0.0037385856,0.097836055,0.06342408,0.024783779,-0.047526915,0.013289139,-0.034212407,0.015203477,0.010163671,0.08133054,-0.066071756,0.021456737,-0.01251436,-0.018776165,0.024241382,-0.022420192,-0.0543022,0.028594214,-0.018274244,0.08908135,-0.088626504,0.030757237,-0.015739845,0.0075350194,0.050263934,0.002867319,-0.059607062,0.0025129307,0.062180694,0.035678722,0.028105693,-0.06532163,0.018059509,-0.06424855,-0.08394407,0.033063613,0.09592739,-0.078989826,0.017452028,0.049832873,0.029691424,0.055496052,0.021778094,0.0029765673,0.123863414,0.07216921,0.0012770154,0.022844214,-0.07211525,-0.013507154,0.012183924,-0.009743915,0.009068153,-0.071068056,-0.060114916,-0.002479139,0.03711341,-0.038954057,-0.08402197,-0.02837621,0.03739564,0.023074424,-0.045019586,0.0758028,-0.0035362255,-0.040439554,0.0016063224,-0.0029750152,0.0274053,-3.401969e-08,0.009346246,-0.10345679,0.111065626,0.017409116,0.019837273,0.080734566,-0.016102996,-0.04223864,0.062465675,-0.016137913,0.030005164,0.085634254,0.08958601,-0.010270119,-0.0713965,-0.016956693,-0.012580755,0.034562368,-0.0038256028,0.0016390077,-0.08898653,0.026377711,-0.0345964,-0.010836197,0.097248055,-0.07832445,-0.094725035,0.07928194,0.025147157,-0.021495333,0.019236935,0.021894464,0.04948486,-0.011936981,-0.023558348,0.036126953,-0.019279297,0.008738288,-0.0846149,-0.043378394,-0.021475732,-0.06838415,-0.07881645,0.0039651636,0.0066208025,-0.033718992,-0.03932401,0.03942591,-0.045610387,-0.038998414,0.037183426,-0.022666562,-0.003935599,-0.019294262,-0.0742378,0.055665962,-0.040208675,-0.09501188,-0.073376164,0.033741996,0.021681637,0.035025455,0.09297674,-0.11225802 +6.2.1.40,"Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle. cf. EC 6.2.1.56, 4-hydroxybutyrate---CoA ligase (ADP-forming).",384,0.99999994,-0.055864125,-0.0096716285,-0.048544034,-0.0020896157,-0.013503629,-0.019991942,-0.06986915,0.025300428,-0.06281302,-0.09756784,0.06979201,-0.14083411,0.009003165,-0.05644418,-0.07247685,-0.024170667,-0.025964828,-0.021647306,0.009327753,0.048847873,0.07913942,0.01578472,-0.043228798,0.022645926,0.052473873,0.031322647,0.0129866395,-0.049391523,0.03637434,-0.08910064,-0.020265527,-0.025519488,0.029836733,-0.098239385,0.102777734,0.012301189,0.00086836587,0.031193335,0.017094746,0.037544165,0.07171491,-0.016953656,0.02740706,-0.06928509,-0.05098583,-0.05652207,0.022448188,-0.022090642,0.019894427,0.026478518,-0.0057773427,-0.10790383,-0.03665809,0.10741379,-0.00036716452,-0.029799324,0.025354622,-0.02731593,0.018431732,0.050305657,0.0614759,0.069469005,-0.07254745,0.0075708986,-0.0037556349,0.009243968,0.043389264,-0.0035943901,0.02392392,-0.022289626,-0.0036484338,-0.021344636,-0.018335447,0.06388998,-0.064134,0.0864796,0.07547186,-0.113639854,0.09483452,-0.01361253,-0.037634764,0.014455673,-0.004884717,0.017117195,-0.0065709967,0.0014000097,-0.02405544,-0.0013202148,-0.013460826,0.036422618,-0.03386116,0.075572334,0.03177148,-0.098527834,-0.0007682246,0.12763257,0.034146562,0.079046905,0.07136133,0.034882683,0.022617461,0.07155765,0.022940593,-0.10008348,-0.055947576,-0.029765585,-0.073031135,0.051558528,0.092756525,0.026344037,-0.014909415,-0.034383353,-0.0045158183,0.006233802,-0.015345289,0.078026555,-0.006961252,-0.03225777,0.0016935534,-0.018591227,-0.017796466,-0.029587569,0.048348114,-0.018538421,0.097752206,-0.018739201,-0.07370614,-4.6412636e-34,0.083370954,-0.08140552,0.033651527,-0.007870317,0.05243376,-0.057295687,-0.058993664,0.014056235,-0.066272244,-0.035852186,-0.052363276,-0.058414705,0.028753312,0.0099389255,-0.029887332,-0.10102293,0.015345002,-0.0009039052,0.018206308,-0.00878942,-0.011616284,0.06787635,-0.026467035,0.006912213,-0.018406263,-0.056642167,-0.032075875,-0.0126349935,-0.01211345,0.03867017,0.0020139613,-0.06874573,-0.12817912,-0.015683126,0.114914246,-0.043311205,-0.005341447,-0.079183415,-0.06538344,0.05646199,0.045602974,-0.0075563937,0.0069794822,-0.0017778532,0.10866977,-0.015384447,-0.04022905,0.065351926,0.079862155,0.015596729,0.041520476,0.04264315,0.024629613,-0.026555695,-0.060644213,0.025649095,-0.09203727,-0.021355823,0.059906088,0.037301123,0.053910516,0.14444035,-0.051887456,0.037633467,0.00365651,0.03233826,-0.047286946,0.0018497701,-0.028633254,-0.072159566,-0.014017941,-0.058368266,-0.008791177,-0.00096019526,0.026723893,0.0225046,0.02114521,0.03357073,0.03962011,-0.008099871,-0.019698229,0.060999244,0.07480919,0.02234824,-0.0330484,0.006263761,0.040156413,0.080747426,-0.02446604,0.048811514,0.10669327,-0.021563005,-0.07348788,0.0011340766,-0.025764965,-3.9842536e-36,0.055316452,-0.039560653,0.045028802,-0.16006902,-0.07650554,0.042893175,0.022359092,0.09830444,0.014862374,-0.005311165,0.09912189,0.05103424,0.046482764,-0.08302482,0.0075734514,-0.010983952,0.053980716,0.04890295,-0.0027971268,0.029413067,0.053238917,0.03061864,-0.0068862494,0.04066618,0.039821465,-0.048243098,0.012873285,0.02627544,-0.012510604,0.095767,0.0049236068,0.052887164,0.03694864,-0.07797609,-0.14271209,0.005342052,-0.08009478,-0.06875892,0.022473978,-0.002739626,-0.06486554,0.049513876,0.02218833,0.06088854,0.0790374,0.05604895,-0.038116116,0.009872156,-0.006029487,0.07724373,0.042893466,-0.018914504,0.039574478,-0.070191056,0.009575218,-0.011815157,0.013898286,0.06931351,-0.015695328,-0.0039007512,0.021063816,0.046725307,-3.2975742e-05,-0.0325439,0.11131736,0.11638826,0.009694282,-0.0038404858,-0.07459444,-0.040123317,0.07023854,0.027225636,-0.01699869,-0.012839586,0.04429653,-0.05101643,-0.044856653,-0.025091449,-0.06408499,0.030661695,0.00047729042,0.027875789,0.041612424,-0.07166435,-0.0055989395,-0.087388046,0.006068534,0.06735303,0.0019804381,0.021784114,-0.054863792,-0.032986987,-0.100171864,0.088799454,0.111704074,-3.5106297e-08,0.009875345,0.020001287,0.026384449,-0.042780966,-0.017790793,-0.012076469,0.022813803,-0.056575518,0.058711108,-0.027255291,0.028376462,0.004752914,-0.009243001,-0.026493996,0.040114224,-0.05263798,0.032464467,0.026776478,-0.048929103,-0.03334064,0.002882625,-0.01675609,0.018206708,0.04879059,-0.008731803,-0.030714221,0.093808144,0.014752592,0.025327329,-0.03564263,-0.026884383,0.03678033,-0.05418221,-0.035055954,-0.06906222,0.026237253,-0.06721383,-0.005607022,-0.03510562,0.031410284,-0.034659803,-0.059661496,0.0060092015,-4.152143e-06,0.03920868,0.029095855,-0.050623372,0.08431971,0.0034995778,-0.09903904,0.043854672,-0.05841481,0.032670442,-0.052068338,-0.028934313,-0.03880759,0.020732015,-0.049307715,-0.06871984,0.009450585,-0.03090467,-0.024899898,0.13272153,0.024260044 +6.3.1.17,"The enzyme, found in animals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.",384,1.0,-0.08944726,-0.056451682,-0.07050582,0.03056445,-0.0009542979,0.10581899,-0.07277018,-0.01089532,0.04161541,0.0003254935,0.023495933,-0.03913456,-0.09360789,-0.006175427,-0.07436153,-0.0055175675,-0.060368,-0.029582372,-0.037380964,-0.08156548,0.022918193,0.007169218,0.022967404,-0.022012435,0.05528393,-0.042530064,0.04080449,-0.067267224,0.028397655,-0.10740647,-0.0007458158,-0.05627764,0.0774356,0.0013595222,0.050248627,0.035888705,-0.0482325,-0.09278169,0.03765994,0.027387591,0.057534546,-0.02998076,-0.038437933,-0.07233086,0.0024860452,-0.042700484,-0.049871586,-0.011202078,0.050603427,0.0113495905,-0.022907946,-0.10493537,-0.004038289,-0.0008853192,0.00027237018,-0.00841376,-0.096101224,-0.05178325,0.015936393,0.056084104,0.072885975,0.041929968,0.04098608,-0.04489875,0.016517244,-0.0667667,0.08772569,-0.08562751,-0.054828882,-0.0053635784,-0.049700793,-0.07949087,-0.025057033,0.06935878,-0.022718793,-0.02956089,-0.044396535,-0.08157708,0.084711246,-0.03138935,0.03550246,-0.013187716,-0.054744847,0.08156566,0.061288126,0.018538572,0.011607146,0.03529602,0.020008989,-0.0012131149,-0.008308632,-0.08774665,-0.033287764,-0.023997879,-0.009425585,0.06200316,0.0034949337,0.09101327,0.06861855,-0.049465895,0.0057984744,0.09194893,-0.0084611755,-0.050144814,-0.0029765705,0.043924063,0.0032274742,0.114422426,0.028763195,0.020293241,-0.052302092,-0.06027635,0.013900867,-0.006271202,0.0014301741,0.09721689,-0.048125025,-0.1040167,0.008128502,0.009211628,0.055157907,-0.0041265064,0.07765903,0.11858219,0.020099763,0.08920923,-0.04891118,-2.3269895e-33,0.059436303,-0.010269689,0.005495174,0.011962128,0.030792367,0.030784247,-0.059356242,0.03647247,-0.046593625,-0.074434064,-0.054119747,-0.013111718,0.055263527,0.03671616,0.02628565,0.017896434,0.018149685,-0.037077874,0.020753562,-0.02806071,0.033536464,-0.024924723,-0.05580675,0.047819838,-0.017208064,0.02495274,-0.043575753,0.029391875,0.07405111,-0.00055122655,-0.0054402263,-0.0943007,-0.03166452,0.052671812,-0.010257428,-0.0072136517,-0.01684816,-0.059915747,-0.01946496,0.056427103,0.08237416,0.05087244,0.031096168,-0.052498672,0.0155364,-0.018779911,-0.057017617,0.029820342,0.065695494,0.030187428,0.035165414,0.00058712,0.13155286,-0.04351973,-0.00010193693,0.08804363,-0.066540726,0.01551816,0.032214597,0.06303895,-0.030098649,0.09394377,0.0108155655,0.0034027535,0.014964707,0.06219025,-0.062289473,-0.047250744,-0.035865724,0.038577504,-0.05077282,-0.055036355,0.044852868,0.051793795,0.061681062,-0.067028895,-0.07900633,0.046804637,-0.024879053,-0.05168794,-0.007491733,0.02241837,0.03092136,0.03083567,-0.04227044,-0.032415997,0.014955518,-0.026489832,0.014758574,0.047513038,0.06403978,-0.059152693,-0.10583013,0.04052809,0.015758157,-8.068e-35,0.08690918,-0.057092875,0.021351561,-0.05727402,-0.09278421,0.10430456,0.014836921,-0.008778146,0.051560514,0.05995504,0.1002406,0.0134215485,0.06111494,-0.08522379,0.05971404,-0.04191467,-0.046487175,0.04473649,0.015550791,0.0066396436,-0.04476815,0.019850342,-0.0013096617,0.035944194,0.07399175,0.01302155,-0.0037047109,0.009705189,0.04037863,-0.016713863,-0.077842,0.0051171915,-0.036631893,-0.04776587,-0.031789932,-0.018116934,0.016080432,0.0008158871,-0.07004783,-0.040149335,0.017216964,0.06127335,0.00388015,0.07229963,0.089228965,0.08701263,0.005928078,0.03149016,-0.078693904,-0.044492763,0.045931462,-0.030948535,-0.010556459,0.01878985,0.037237532,0.062043414,0.0002517015,0.0337616,0.056878887,-0.04830841,-0.032997213,-0.03419431,0.035643324,-0.010528916,0.02490335,0.025911257,-0.05620483,0.062285278,0.02186056,-0.021364814,0.03311806,0.01571223,-0.0031702183,0.0022278503,-0.03319696,-0.0038515022,-0.03561336,-0.08128752,0.027542753,-0.10471459,-0.0036790527,-0.0048192353,-0.01831877,-0.042225767,-0.038710088,-0.04444662,0.019231642,0.14402486,0.004163293,0.05589936,-0.09797362,-0.051977847,-0.13332197,0.0107062245,0.009679199,-2.8413071e-08,0.027176095,0.021092014,0.03346128,-0.09885246,0.06271018,0.0030115112,0.03644254,0.042386785,0.07177752,0.021692257,-0.044934202,0.06748414,0.061579816,0.010254298,-0.022140663,-0.0075918585,0.012302798,0.049296923,0.0061754882,0.06964146,-0.05557204,0.021839717,-0.0564021,0.0043790517,-0.003972175,-0.07463957,0.06674636,0.06931828,-0.04130834,-0.03783067,-0.06413298,0.040009603,0.0422006,-0.026829617,-0.030132836,0.010849972,-0.009101517,-0.06195065,-0.033691484,0.042637754,0.016199663,-0.06217383,-0.035480373,-0.03530333,0.027545175,0.02776268,0.023742499,-0.05399328,-0.022885539,0.010094253,-0.035817545,-0.051430397,-0.0331666,-0.09030202,-0.08672364,-0.036259264,-0.043262396,-0.12626334,0.021592688,-0.04855492,0.039914705,0.018616663,0.1982631,0.04027851 +6.3.2.41,"The enzyme, found in animals, produces the neurotransmitter N-acetyl-L-aspartyl-L-glutamate. One isoform also has the activity of EC 6.3.1.17, beta-citrylglutamate synthase [2], while another isoform has the activity of EC 6.3.2.42, N-acetylaspartylglutamylglutamate synthase [3].",384,1.0,-0.08380108,-0.09754668,-0.06334918,0.017168263,-0.06199045,0.11463201,-0.058369964,-0.0075128432,0.07902135,-0.03079544,0.05028862,-0.060807746,-0.06890035,-0.0073509663,-0.035444897,-0.022408267,-0.036819823,-0.041960698,-0.040634137,-0.08609598,0.022903198,0.03973119,-0.016372839,-0.037218247,0.077941984,-0.0026670399,0.03514602,-0.088945165,0.09932335,-0.11014592,0.015978236,-0.066735186,0.037981376,0.009568263,0.044847753,-0.0006286724,-0.11482311,-0.088718385,0.083111815,0.008243249,0.0547737,-0.0011504916,-0.014344819,-0.037535578,-0.0165549,-0.034801196,-0.019471275,-0.022500906,0.02915069,-0.040124033,0.017106147,-0.095802665,0.014100362,0.061940163,-0.0076725357,-0.017117478,-0.09393296,-0.046892196,-0.019620594,0.110128865,0.03057561,0.10442303,0.010064301,-0.08086294,0.009563115,-0.014462776,0.052066043,-0.08501033,0.011423156,-0.057611085,-0.09354515,-0.085416734,-0.02501035,-0.0011396122,-0.05331581,-0.02746854,-0.009964809,0.0014004416,0.019108653,-0.060693085,0.04484495,0.0141173545,-0.023023661,0.05575022,0.050810587,-0.0040339143,-0.04005769,0.09501797,0.026783777,0.028512824,-0.023355626,-0.0480115,-0.03590895,-0.06873167,-0.04263306,0.016241191,0.010956289,0.09812522,0.067066155,-0.019965205,0.02370834,0.13444194,-0.025618015,-0.06927569,-0.0061455932,0.074181676,0.03173753,0.062644206,0.06059632,-0.015105455,-0.06806625,-0.005260118,-0.022561656,0.014682174,-0.03102378,0.054187097,-0.053205814,-0.06432431,0.030107094,0.0373421,0.065931775,-0.022265127,0.046362076,0.090125985,-0.019854844,0.06531625,-0.06824103,2.5675475e-33,0.046072956,-0.0032721735,0.007933837,0.018720496,0.03505037,0.04340195,-0.055202357,0.022612229,0.023067798,-0.0802912,-0.07925675,-0.04113945,-0.011109165,0.09666838,0.06618596,0.016883176,-0.027508387,-0.03520937,0.07716804,-0.040106688,0.018870741,0.032645665,-0.054380625,0.016703272,0.008126049,0.028363217,-0.05752307,0.068157144,0.019377211,-0.009545331,-0.014528375,-0.0884028,-0.042832453,0.022659095,0.00877234,-0.0001703119,-0.010608862,-0.030167956,-0.0011207003,0.03672303,0.07365282,0.05665398,-0.055431426,-0.026190313,0.043605216,0.00096700626,-0.059477262,0.011826356,0.08133566,0.00797878,0.036734585,-0.017955206,0.12437668,-0.04416128,0.021930251,0.06803696,-0.056520183,0.003306075,0.04867487,0.06778484,-0.03519389,0.06556803,-0.017277118,-0.015321795,0.015194822,0.09346762,-0.05651658,-0.07758135,-0.031985793,0.006213105,-0.07100315,-0.016259428,0.036250442,0.05103471,0.033009287,-0.07362457,-0.119586974,0.013053498,-0.016998516,-0.039631754,-0.03645602,0.0492974,-0.0031321042,0.016236681,-0.010391213,0.0026656808,0.042354632,-0.032824542,0.032686792,0.023293987,0.02498083,-0.032894492,-0.07201737,0.041485608,0.05754827,-3.3583392e-33,0.029613819,-0.054795247,0.0073800655,-0.07710329,-0.092324175,0.08368582,0.01314089,-0.041264217,0.015106342,0.102954924,0.052671168,0.050442286,0.05144884,-0.058199067,0.050949477,-0.067343846,-0.030400652,0.09974706,0.034099,-0.0014756434,0.018230991,0.039362725,-0.0076080887,0.027137198,0.06769422,0.015980976,0.0064377594,0.06434893,0.03751623,0.051119503,-0.0243627,0.025139078,-0.001283725,-0.09828742,-0.043805957,-0.013245796,-0.004048184,0.03600593,-0.09142251,-0.044937,0.059003714,0.10821514,0.054085623,0.086732,0.06421305,0.055093184,-0.028294561,-0.020357281,-0.06630842,-0.04126188,0.048619617,-0.04801285,-0.029028868,-0.04245831,0.0291293,0.060909044,-0.0052409386,0.001985303,0.050158337,-0.05818906,-0.0708338,-0.050830472,0.02556137,-0.052732226,0.060463198,-0.000715485,0.023654958,0.119201645,0.029248394,-0.00093639985,0.031899758,0.012142679,0.030467788,0.006895036,0.00079758686,-0.0012500582,-0.05056357,-0.060798924,0.021091875,-0.088341646,-0.019169902,-0.02840846,-0.062810324,-0.0778135,-0.023598924,-0.024103189,0.021090377,0.14559539,0.020476943,0.050795473,-0.057759352,-0.025411103,-0.08367509,0.022783484,0.03982615,-4.2970925e-08,0.05049826,-0.007490572,0.039162446,-0.0529328,0.047463804,0.029898709,-0.008603416,-0.018426929,0.03508151,0.01824864,0.0044370405,0.02952854,0.010125504,0.0117142275,-0.049319297,0.025372626,0.012396048,0.082196705,0.02216053,0.056885354,-0.015991176,0.02834038,-0.043660957,0.0035384553,0.032770116,-0.08798225,0.032542065,0.10683026,-0.04958485,-0.010489731,-0.027035728,0.06251894,0.065751545,-0.04927653,-0.026898138,-0.030968135,0.034484256,-0.05115773,-0.0063315146,0.013336519,-0.008841246,-0.07614211,-0.027542304,-0.016667768,0.010626874,0.032203995,0.042394817,-0.045182668,-0.010545096,-0.023810938,-0.009178826,-0.08727343,-0.019983936,-0.061522063,-0.069401346,-0.033103865,-0.07315331,-0.069543146,0.019202502,-0.080900244,0.036737904,0.039157733,0.14322849,0.030769398 +6.3.2.42,"The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.",384,1.0,-0.08942304,-0.04823939,-0.0829101,0.029096764,0.0039319065,0.098029695,-0.07173196,-0.0029989725,0.030561948,0.016158178,0.01965961,-0.047142886,-0.109618366,0.0017881213,-0.062038854,-0.017454397,-0.06928514,-0.030983837,-0.02075941,-0.08154806,0.02613336,0.016302511,0.020377083,-0.024673356,0.04932531,-0.04698578,0.046369646,-0.066359036,0.028127903,-0.117435746,-0.007701559,-0.074383534,0.091364175,-0.009636861,0.061114237,0.031240668,-0.046575833,-0.08949821,0.035661917,0.023583187,0.064508945,-0.025295308,-0.03135235,-0.061457418,0.0030103992,-0.037877664,-0.047508158,-0.008173354,0.0406841,0.030767791,-0.009157935,-0.09151387,-0.0125408005,0.0029530192,0.002976767,0.0057968292,-0.09060808,-0.059812907,0.024484674,0.051451076,0.06534985,0.03980051,0.026606398,-0.051481783,0.0197637,-0.07084001,0.08973071,-0.09759227,-0.06251313,0.0007308577,-0.052178126,-0.07734538,-0.03556568,0.088767804,-0.031362206,-0.023993757,-0.03995874,-0.07798243,0.07816706,-0.018973012,0.04791629,-0.01129779,-0.06724981,0.0757861,0.055627223,0.02113836,0.002733347,0.030708408,0.014668135,-0.0050399434,-0.011758501,-0.088785335,-0.032762412,-0.034901965,-0.025288157,0.06495026,0.0006554513,0.1027202,0.061392244,-0.050187584,0.0091004595,0.08756834,-0.0063109486,-0.050301265,-0.010635602,0.046468195,-0.0025647155,0.1094088,0.0436189,0.014250799,-0.04879972,-0.053196803,0.0041387216,-0.008379226,0.012938023,0.09246621,-0.04346457,-0.10175323,0.018060729,0.006382046,0.04813879,0.008774123,0.07954173,0.12402565,0.018155249,0.0810359,-0.0325786,-2.6110455e-33,0.060843036,-0.0072301296,0.016913418,0.01324325,0.020803865,0.040804178,-0.051040065,0.03756949,-0.051845763,-0.076997824,-0.05008434,-0.018355127,0.06559537,0.038800273,0.012138437,0.020856021,0.017343692,-0.03900357,0.0062085427,-0.03455319,0.036985163,-0.022472488,-0.05139321,0.05186289,-0.013046085,0.019088108,-0.042489797,0.020524582,0.07724224,-0.0058974423,-0.020723704,-0.068664715,-0.03844791,0.058078587,-0.010455413,-0.017888244,-0.008149315,-0.055609424,-0.003298249,0.051250033,0.070863165,0.04932743,0.024410427,-0.06133045,0.009047612,-0.017730867,-0.04687144,0.023570273,0.06008403,0.015329258,0.031355463,-0.008244501,0.12575793,-0.022861367,-0.003930784,0.07720557,-0.05793805,0.01679517,0.022959394,0.060694747,-0.0081999265,0.091740094,0.0034897781,0.017753685,-0.0011653221,0.06570035,-0.061341774,-0.056729157,-0.020684721,0.0454491,-0.05150796,-0.06010243,0.047326256,0.053858485,0.059688285,-0.06152289,-0.08055156,0.06760045,-0.022966266,-0.03610254,-0.010687528,0.024196243,0.033668935,0.028367847,-0.023812547,-0.03844987,0.009281466,-0.030086527,0.021909753,0.053704724,0.059211813,-0.055842772,-0.10649615,0.049605593,0.014761115,-8.436776e-35,0.09181974,-0.05460553,0.030452123,-0.061197657,-0.08876292,0.10301413,0.016234407,-0.0061229453,0.034845408,0.042948127,0.107761465,0.0069026262,0.063799575,-0.09062049,0.08263541,-0.039403405,-0.046233088,0.054923687,0.019376455,0.01121619,-0.02706129,0.007114441,-0.018000802,0.037162077,0.088215016,-0.0055042203,-0.0011507269,0.00028634095,0.037645046,-0.016745659,-0.089013144,0.008771419,-0.03880298,-0.045370854,-0.020919362,-0.015481525,0.015053214,0.008385879,-0.073071174,-0.041040245,-0.00019734929,0.07665072,0.021706982,0.07957713,0.08867497,0.07280603,0.007604366,0.03640784,-0.09130756,-0.031231374,0.045828678,-0.040621817,-0.020895092,0.010111101,0.017805127,0.05950287,0.0015828194,0.03014004,0.058695864,-0.045633584,-0.03849023,-0.034986556,0.014933882,-0.02873722,0.03327598,0.02401425,-0.057837274,0.06584991,0.012939138,-0.010248908,0.03925956,0.0007740383,0.0052053058,0.0027455036,-0.022226557,-0.0056093293,-0.031413242,-0.08181038,0.029387496,-0.10074132,-0.009453309,0.014077914,-0.015123115,-0.037384406,-0.0405261,-0.039171845,0.023124682,0.13174635,-0.0068781003,0.06350982,-0.10673972,-0.049698353,-0.13647133,0.010581375,2.6231608e-05,-2.8435815e-08,0.027467338,0.031769235,0.02507849,-0.090879805,0.0539246,0.009768576,0.04411412,0.047511403,0.078542344,0.01409029,-0.057088096,0.066006675,0.07440712,0.015688771,-0.026390849,-0.006124893,-0.0035240569,0.05572625,0.0071177385,0.0746802,-0.045082908,0.011817736,-0.0656192,0.02277069,-0.004971283,-0.065589465,0.064767346,0.069618866,-0.03453374,-0.03609808,-0.056427024,0.027771337,0.039560884,-0.020397278,-0.027072504,0.018654114,0.0029214283,-0.06550512,-0.043840777,0.030908592,0.017326979,-0.061237406,-0.031082282,-0.026531154,0.019792415,0.017234098,0.0066618617,-0.05741725,-0.029660027,0.006847643,-0.039225295,-0.06322799,-0.03151937,-0.08104671,-0.07388215,-0.05295808,-0.044006176,-0.12702835,0.014271535,-0.043001015,0.04639669,0.023087278,0.20296916,0.041685574 +1.1.1.374,The enzyme from the archaeon Methanococcus maripaludis is activated by KCl (200 mM). 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+1.1.1.372,"The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.",384,0.99999994,0.013440766,-0.013494976,-0.029586248,-0.01479974,0.0006720644,-0.010976714,-0.06212652,0.00024794738,-0.013495177,0.03402852,0.014850817,0.049275674,-0.065173194,0.00892955,-0.124948606,-0.013373922,0.010690235,0.049404927,-0.003970082,0.027738199,0.106537335,0.025907809,0.02892075,0.02898496,0.08114919,-0.03648251,0.027877871,-0.06035112,-0.05477356,-0.08893805,-0.007254897,-0.042219676,0.006444475,-0.0052598338,-0.017932594,0.08395402,-0.03353517,-0.01732645,0.06051418,0.03544958,-0.026892588,0.0013971824,-0.008700561,-0.05620763,-0.06475744,0.009555724,-0.07073413,-0.009369194,-0.005661662,-0.0048824577,-0.008619315,-0.043290533,-0.015077729,-0.022850355,0.067972906,0.10514113,-0.020592095,-0.046260238,-0.006614333,0.094372615,0.06460957,0.035672873,0.024920486,-0.0053490824,-0.010780571,-0.080750905,0.06788155,-0.03602422,-0.03830321,-0.041698653,0.009001386,-0.060638066,-0.056174953,-0.08420009,0.03755479,0.040200893,-0.0020767308,-0.051269617,0.09750029,-0.056962807,0.09956819,0.046902318,0.09012336,0.0143682165,-0.047876496,-0.033628475,0.03404212,0.010419193,-0.020783225,-0.020396078,0.08347379,-0.013142128,-0.051046494,0.021167036,-0.050014492,-0.029855715,0.05656728,0.013396864,-0.016225388,-0.040588487,-0.008524318,-0.005316396,0.006132431,-0.07514496,-0.014412331,0.06186255,0.016197063,0.066441886,0.13180919,-0.0040100566,0.016153496,0.037170965,0.013986205,0.021239642,-0.055915903,0.06713002,0.05632127,-0.007393842,-0.04523266,-0.024275897,0.029018722,-0.016310548,0.03658088,-0.038683623,-0.016411597,0.050801273,0.01978873,3.8765956e-33,0.09451238,0.041410033,-0.0782443,-0.043348428,0.0013650939,0.001145039,-0.08027915,-0.01787253,0.02170406,-0.06530627,-0.071902886,-0.0540202,-0.071297206,0.0972323,-0.03980076,0.07286815,0.018721968,-0.06422716,0.039777115,-0.039731264,0.0064040003,0.054128084,-0.08101742,0.0012562345,0.095436566,0.055389777,0.01810934,0.05315916,0.047592342,-0.0029266956,0.040177077,-0.08327366,-0.11288256,0.029858219,0.09476017,0.054398347,0.0016804513,-0.00793374,-0.0103332605,-0.015210033,-0.03563194,0.013263478,-0.034936164,-0.06655268,0.005122974,-0.0074874186,0.00010233886,0.079111084,0.032012694,0.036644857,0.059743397,-0.013552329,0.035605073,0.06738022,-0.059735008,0.06127268,-0.016957844,-0.022142993,0.07983648,0.06605108,-0.00059216295,0.048217,0.00724081,0.049436808,0.056839317,0.039046817,-0.06760397,-0.041492175,-0.023284532,-0.018920725,-0.07437973,-0.0592113,0.0638195,0.0045121238,-0.073512636,-0.05418989,-0.0019271187,-0.019917438,-0.005592312,-0.056333154,0.014631184,0.035373915,0.010849444,-0.040577613,-0.009455257,0.042774465,-0.031075617,-0.059902996,0.018599173,0.02310154,-0.04190477,-0.014308453,-0.021007339,-0.019220684,0.0020066071,-5.1915315e-33,0.08406499,-0.07823073,0.06389784,0.022552697,-0.06024661,0.09257556,0.00557201,0.048965324,-0.006898495,-0.109594174,0.0012310805,0.025592225,-0.00046200896,-0.038680017,0.034991268,0.008944453,-0.016893543,0.08576922,-0.08177426,-0.0051808604,0.0072162477,0.112708464,-0.071022406,0.015346315,0.049841657,-0.039634775,-0.023645572,0.034085874,0.053554483,-0.0042683454,0.049638882,0.015811253,-0.044986185,-0.029088827,-0.056552127,0.07159207,-0.051200144,0.021508863,-0.057826526,0.038139887,-0.0032172864,-0.01019133,0.030626256,0.057557527,0.086967856,0.09388694,-0.12355672,-0.0044984715,0.050008398,-0.014926977,0.010720296,-0.024454521,-0.0024549132,0.03687181,0.034974825,0.020567313,0.07546361,-0.031007923,-0.040260356,-0.009087586,-0.06407222,-0.02633615,0.07304517,-0.06936378,0.068144016,0.037362024,-0.02612755,0.0324386,0.08027981,-0.04634076,0.10816199,0.024412315,0.004796862,0.049724255,-0.017311564,0.006159574,-0.116085604,0.022017008,0.016845394,0.03107183,0.09829307,0.039775327,0.03930654,-0.021318972,-0.029396236,-0.07589095,0.030760113,0.14126343,-0.052873485,-0.002160641,-0.02949998,-0.028909838,-0.040470112,-0.008077636,0.043356404,-3.808251e-08,0.08227778,0.008310312,0.028335942,-0.13133185,-0.029308591,-0.0074720876,0.087779365,0.06669563,0.021689396,-0.05927897,-0.057956308,0.10465276,-0.07206315,0.011565117,-0.029559964,0.02448834,-0.056809988,0.052614596,-0.036867265,0.06095411,-0.077230096,-0.049890004,-0.11462285,0.05502956,-0.046841845,-0.060268,0.08846833,0.05849748,-0.025301024,-0.010240234,0.012203451,0.08702172,0.01477422,-0.018708387,-0.07955484,0.000233668,-0.027612353,0.009487846,0.015943099,0.03721266,-0.0380001,-0.045897037,-0.0041679954,-0.021482626,-0.081462555,-0.07634696,0.012326198,-0.002477457,-0.04869425,0.069884,-0.035147935,-0.018262545,-0.09176364,-0.045551483,-0.10128718,-0.04847921,0.006519006,-0.012505158,-0.06886825,-0.10594179,0.008376528,-0.072216086,0.11303386,-0.018128064 +1.1.1.373,"The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea.",384,1.0,-0.081105225,-0.048594564,-0.10848376,0.008835624,0.046745438,0.032828197,-0.049831737,0.032870505,0.07586287,-0.02913979,0.05445136,0.009486292,-0.059808504,0.07226813,-0.03937746,0.070400394,-0.1304683,0.029386794,-0.024048015,-0.028893366,0.05958483,0.045026932,-0.09444737,-0.0056915265,0.019239303,0.0630403,-0.059983052,-0.049416408,-0.09797374,-0.008290234,0.027908891,0.012696363,0.057618678,-0.035901356,0.07355347,0.1522308,0.028199598,-0.10104334,0.0683804,-0.004423828,-0.018378016,0.0072768857,-0.054817714,-0.0065369243,-0.035815757,0.026034571,0.010792563,0.058089305,0.060984876,-0.13011214,-0.068549275,-0.03453788,-0.06960186,0.019426117,0.028898627,0.030748924,0.051367465,-0.029543107,-0.014377658,-0.030635532,0.01817062,0.004598654,0.024005316,0.0049432805,0.0040045623,-0.025003677,0.03586843,-0.061665494,0.07767121,-0.002634982,-0.10855647,-0.034419484,-0.04132187,-0.021449795,-0.053963292,0.058112852,0.002740639,-0.045448102,0.0063986606,-0.06776737,0.061440136,0.03541591,0.023777848,0.08512765,0.048423767,-0.024969043,0.06765369,-0.050296754,0.067554966,0.02532024,-0.0014836654,-0.05090578,-0.008883265,-0.07645724,-0.05743536,0.025233941,0.013815054,-0.021189751,-0.0104850605,-0.013478761,0.018099561,-0.024771795,-0.048207175,-0.114914246,-0.0254176,0.018596342,0.014751947,0.06833244,-0.0031445203,0.001346658,-0.044024188,0.0033087449,-0.02154747,-0.011625926,-0.018472224,0.054106038,0.08257015,0.0059516155,-0.1299897,0.10004439,-0.07007859,-0.013911042,0.0050511532,0.0149930725,-0.0122365225,0.08648806,-0.14280026,1.1601745e-33,0.123134084,0.01616118,0.05361562,-0.07913103,-0.025008857,-0.04411759,-0.050337482,0.01412914,-0.03370879,-0.056220617,-0.059754733,-0.06865937,0.008383214,-0.015326728,-0.007194241,0.021339592,-0.053300068,0.03258519,0.017026197,0.004868905,-0.06462804,0.012327643,-0.01905368,-0.06327321,0.034399852,0.026704304,0.012897256,-0.03153275,-0.028984167,-0.00077295443,0.09466792,-0.09642048,-0.12007767,0.04579283,0.13495424,-0.0058387783,-0.009034631,-0.026895141,-0.01834693,0.027129447,-0.046964817,0.062556654,0.037711397,0.0032459437,0.027164161,-0.020968975,-0.045867275,0.09211938,0.03900813,0.06517287,-0.03568121,-0.012652869,0.07132777,-0.017910345,-0.011031827,-0.02958268,0.014312298,0.016845088,0.003154783,0.0004091409,0.03579222,0.044870023,-0.07905116,-0.033796947,0.05636474,0.07166189,-0.024296843,0.05565058,0.022828927,0.032644838,-0.06066331,-0.07223315,-0.019470055,0.07090165,0.036945608,-0.030262005,-0.026062299,-0.002204743,0.012109821,0.030730639,-0.042406786,-0.06855791,-0.0038989258,-0.09200474,-0.107197665,0.024448235,0.010689955,-0.0024143988,-0.071096554,0.018730402,0.010029817,-0.032258693,-0.0031681375,0.009040636,-0.0059305755,-2.7808596e-33,0.015003369,-0.05452655,0.023027115,-0.11637855,-0.093934,0.03149038,-0.06955213,-0.008205699,-0.0065954006,0.06255354,0.014117333,0.06334124,0.03594257,-0.046110697,-0.017452555,0.013863838,0.04405759,-0.027869068,0.029875813,-0.029873336,-0.008636987,0.10606709,0.046726547,0.022122815,0.023141013,0.018018931,0.0035001736,0.02622125,0.063791856,0.01568855,0.013999732,0.00057380646,-0.001937919,0.0029858793,-0.07605887,0.007589528,-0.046934437,-0.022978526,0.04898236,0.031662956,0.044483267,-0.03377986,0.060680397,0.07631676,0.018495454,0.0053169583,-0.09346859,0.07669296,-0.007932083,-0.0059235473,-0.02240669,0.027454212,0.015097388,0.04584151,0.018141516,0.023740614,-0.0030809965,0.03453002,-0.058558963,-0.029093096,0.03317917,-0.055878572,-0.00011734147,0.027557913,0.023823801,0.061577402,0.014241196,-0.011455841,0.0041630627,-0.023307366,0.04750189,0.0108008385,0.0051804595,0.0019943805,-0.059286524,-0.018024353,-0.05478696,0.017430909,-0.027145715,0.017571095,0.03176348,0.034560975,0.0026827103,-0.080313444,0.06640434,-0.10730782,0.014470957,0.045994163,-0.025761962,0.012708649,0.0050877533,-0.0109651815,-0.057757158,0.044751782,0.04352304,-3.234832e-08,0.035897054,-0.01923053,0.087022826,-0.020596482,0.00695203,-0.019256637,0.04693385,0.093760826,0.06628972,0.045912772,-0.0037790635,0.09116307,0.032803293,-0.01146838,0.09288415,0.028900972,0.016244136,-0.019734358,-0.014771229,0.0028765146,-0.021691596,-0.10516877,-0.10397288,0.040435523,0.02400715,-0.061237276,0.11301135,-0.0095522385,-0.06994482,-0.014365158,0.053652797,0.033525847,-0.020851094,-0.041746866,-0.04165446,0.03375187,-0.09469202,-0.07120259,-0.03269431,0.05770823,-0.025293592,0.05529502,-0.09381548,0.03377349,0.0580351,0.07190426,0.06753908,0.042631783,-0.06782231,0.030712964,0.062613115,-0.032731947,0.027466508,-0.051476676,-0.15002768,0.031094102,0.08546457,-0.02689769,0.00089231535,0.04779797,-0.0015588738,-0.030498687,0.14564575,-0.013327105 +1.1.3.46,"A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.",384,1.0,-0.051401444,-0.026837885,-0.1336671,-0.0031466053,0.048820846,0.039193075,-0.037965637,0.047422137,0.087068304,-0.085017726,0.05019017,0.03462697,-0.017594961,0.026398543,-0.13196474,-0.0003261958,-0.06922924,-0.022747455,-0.07550895,-0.003092705,-0.038331665,0.04256747,0.02926237,-0.027755367,-0.010966581,-0.029583283,0.018039357,-0.02249595,-0.018531585,-0.016066968,0.111671165,0.02167171,0.051379666,0.012043556,-0.014014233,0.03317199,-0.005736503,-0.069955885,0.11074044,0.02578301,0.0007154226,-0.029902587,0.034231078,-0.04986441,0.044981044,0.0011172936,-0.014983637,0.030640662,0.044626117,0.049920984,-0.04171409,-0.036113158,-0.089175105,0.06953759,0.05860114,0.026192874,-0.048517454,-0.06377264,-0.069265686,0.03862078,0.0043201554,0.06625031,0.038877714,0.004895646,-0.026949627,-0.07051246,-0.04531862,-0.055559553,0.040337496,0.0064142435,-0.024589159,-0.04455428,-0.036733925,0.02530264,0.0057866736,0.0420693,-0.046532266,0.064444326,-0.0032509116,-0.063358925,0.06491595,-0.021338727,0.0042684334,0.1003329,0.016800517,-0.071592174,0.004657287,0.03826693,0.04548157,0.10335341,0.007829313,0.022793667,0.040467646,-0.05219868,-0.026218858,0.0011755006,0.010412388,-0.052808143,-0.049111433,0.031581476,-0.035933465,-0.019647801,0.053392626,-0.060408324,-0.081378765,-0.021751573,-0.009596274,0.022123013,0.03399551,-0.08571199,-0.00047510868,0.0108990865,0.009610284,-0.090090744,-0.03108809,0.041044302,0.030316291,-0.07705687,-0.023135453,-0.02046437,-0.015059391,0.056432944,0.045319013,0.095961496,0.022882326,0.048224576,-0.16945584,2.544272e-33,0.055397637,0.050763372,0.02535388,-0.042413227,0.05410321,-0.051705685,-0.010474512,-0.020886984,0.0020427753,-0.028562203,-0.13721363,-0.03147713,-0.0017842428,-0.03593279,0.024391575,0.03996707,-0.028520666,-0.0049522878,0.030363712,0.007012478,0.064097166,0.012647199,-0.006516568,0.0049364776,0.0664277,0.033239327,-0.021746537,-0.025740301,0.06174889,0.007931481,-0.065929696,-0.055515457,-0.058987252,-0.019715074,0.054288127,-0.0048331176,-0.054672267,-0.092681356,0.02701189,0.08927991,0.060163233,0.002204158,-0.022186998,0.01976385,0.03893021,0.09826171,-0.061257727,0.10343869,0.018392967,0.072183736,0.06949859,-0.09854803,0.08232865,0.027316155,-0.044109177,0.059104253,-0.02665154,0.052288614,0.028982589,0.06391589,-0.04365911,0.036291067,-0.005532459,0.013582315,0.016602267,-0.0022163552,-0.01847538,-0.032624006,0.012593411,0.027515616,0.008320666,-0.061440617,0.118205935,0.019313304,0.045486815,-0.0087051205,-0.095090695,-0.074368075,0.02292303,0.019507445,-0.028869921,0.031106217,-0.045955483,-0.05711657,-0.04325131,0.028397672,0.012119435,-0.032050002,-0.030884486,0.016451133,0.037695993,-0.062071595,-0.009219426,-0.026526377,-0.025712438,-3.370547e-33,0.0025123402,-0.14365785,-0.03688516,0.022326572,-0.008177765,0.0020956178,-0.032516442,-0.021755228,0.0138411205,0.024288911,0.032429036,-0.08865378,0.0062468937,-0.03553934,0.002912456,-0.0071911854,-0.006522622,0.1065722,0.037116606,0.017706767,-0.046578724,-0.016996648,0.03763465,0.006710791,-0.0035710153,0.04834376,0.035239328,0.07077837,0.019507034,0.059909116,-0.065952264,0.029477764,-0.06509619,-0.08466152,0.007959505,0.09330964,-0.012265655,-0.030955812,0.01973775,-0.021231031,0.018561712,0.032604564,0.04177945,0.0679588,0.027352188,0.049203563,-0.05322724,0.04128073,0.021552019,-0.036968067,0.024874002,-0.021797001,0.015473183,0.071509786,-0.03619054,0.036181644,0.033859186,0.07008645,-0.00686677,-0.007497112,-0.040890187,-0.115979575,0.02753142,0.011629005,0.033063985,0.07335249,0.040016264,0.10635471,0.04865433,-0.04668975,0.0792837,-0.030913156,0.092072375,0.08652122,0.0360085,0.051650017,-0.044252675,-0.0021443635,0.017232457,0.007649599,-0.0015470887,-0.035565842,-0.030714478,-0.017073967,-0.07144945,-0.10443072,0.03389935,0.12406473,0.056004148,0.011101662,0.022683054,0.024862692,-0.05284118,-0.02579522,-0.0015956255,-3.8603314e-08,0.026060807,-0.084641784,0.030912934,-0.004146788,0.07627469,0.019061865,-0.027467566,-0.002821742,-0.023914592,0.0020850152,-0.029495172,0.089947,-0.07573892,-0.06085237,-0.017555285,0.020992763,-0.020670496,0.063896626,-0.0045164125,-0.008809518,-0.07930029,0.06487182,-0.107622504,-0.017320933,-0.000640258,-0.057289995,-0.019290864,0.000537388,0.03577624,-0.063430965,0.018763568,0.053408414,-0.02922118,-0.050204664,-0.16465598,-0.06965526,-0.040694512,-0.04817311,0.032692138,-0.025392197,-0.054804634,0.00552484,-0.048388466,-0.035123866,-0.05272184,0.0028348304,0.01721987,0.030299623,-0.031216746,-0.0381221,0.014001854,0.033042695,-0.0221593,-0.017752562,-0.10068128,-0.03513306,-0.0055710915,-0.050963745,0.004668841,-0.08559657,-0.115995914,0.04655537,0.19021204,0.048055425 +1.3.99.36,"Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide.",384,1.0,-0.032456916,-0.027740482,-0.089316964,-0.045958117,-0.002961064,0.028884271,-0.041892093,0.109519064,0.080193765,-0.01512403,0.021645973,0.014569381,0.11594572,0.050551426,-0.07667217,-0.0026731237,-0.008066166,0.004738661,0.04835953,-0.003705698,-0.018629033,0.13108301,-0.004111675,0.025100183,0.049724866,-0.00058050745,-0.021520862,0.02717157,-0.04535746,0.006743739,0.06368085,-0.033759635,0.015587007,0.0096990345,0.063224986,0.06740242,-0.053252447,-0.010636686,0.14169648,-0.008580103,-0.048208967,-0.005637103,0.010238962,0.0043011457,-0.004547547,0.073006704,-0.008891172,0.053627774,-0.0034656595,-0.03243662,-0.0060729575,-0.05539602,0.009984685,0.047179632,0.055144764,0.021355193,-0.044974808,-0.0676537,-0.036159195,-0.059547134,0.03509363,-0.023565369,0.03829203,0.0060683447,-0.10331501,-0.059306864,-0.02457509,-0.058097854,0.044619054,-0.051554706,-0.046874445,-0.06736813,0.01791585,0.040948205,0.014488327,-0.024766633,0.020732239,-0.030395905,-0.08535684,-0.027224509,0.06764043,0.008995717,0.014713423,0.089895494,0.054419246,-0.03446547,0.08457736,0.056892134,0.012936592,0.011723165,0.096016295,0.05925469,0.012504643,-0.055372622,-0.09321181,-0.06510618,-0.014140607,0.027622508,0.024015062,0.04836556,0.015776142,0.017328283,0.018683745,-0.02156262,-0.014017511,-0.019651288,0.03076618,0.07748792,-0.0063124364,-0.08114711,-0.007748275,-0.05383716,-0.0677185,-0.051399346,0.011032639,0.07233242,0.15769073,0.010457386,-0.03802415,-0.05937902,0.024156725,0.025244504,0.03778906,0.07659293,-0.044354647,0.048010178,-0.14835086,1.6715058e-33,0.0043472294,0.01619525,0.046894863,-0.007920927,0.03906349,-0.003705285,-0.055910923,-0.043050393,0.058762386,-0.035886955,-0.07729061,-0.06346346,0.024675637,0.056249306,-0.011209756,-0.050672572,-0.052467212,0.035379548,0.054028973,-0.03402403,0.043169163,-0.00520789,0.01930258,0.023921493,0.052091688,0.064391725,0.007409951,-0.015085008,0.079094544,-0.03524792,-0.073822044,-0.020558385,-0.06916133,-0.02842628,0.069312744,-0.044305265,-0.03888149,-0.079858035,0.12786423,0.057104576,-0.059770245,-0.041894484,0.046204265,-0.07046717,0.102237925,0.014345211,-0.07568394,0.020434942,-0.03204488,-0.0049018404,0.09250216,-0.07978434,0.014574565,-0.028370887,-0.09692579,0.024318218,-0.02019072,0.06134233,0.023966175,0.02840248,0.019600019,0.009372059,-0.03919954,-0.011545582,0.030066937,-0.008407235,-0.04333083,-0.036508556,-0.028807335,0.0592685,-0.055130485,0.02720567,0.080789275,0.01846577,0.086699426,0.001633857,-0.12813021,0.031045701,0.08777004,0.041904017,-0.056676608,0.011901013,-0.123088,-0.043252904,0.029177967,0.025874175,0.04299936,-0.07553779,0.026856724,0.04940277,-0.035410132,-0.06033356,-0.08294105,0.02679267,-0.024442008,-3.796957e-33,0.08441471,-0.052364375,0.053074934,-0.006846271,-0.016337264,0.03345058,-0.084325016,0.01912666,0.03723937,-0.056986775,0.052870166,-0.027733464,-0.057762466,-0.018149259,0.044108693,-0.022610748,-0.033387963,0.036200292,-0.064012915,0.044974364,-0.020000655,-0.019852236,0.028825825,-0.0134742465,0.0403204,0.0109170545,0.016932823,0.07388085,0.09842447,0.0343828,-0.056083236,0.004094066,-0.0055965455,-0.105549626,-0.03527471,0.124327704,-0.12770028,-0.015640043,0.056897286,-0.037160177,-0.012583613,0.0019203128,-0.031169526,0.057358023,0.020143775,0.032730613,-0.018317115,0.064312994,0.022225168,-0.07313249,0.026860101,-0.014124019,0.047293495,-0.035718083,-0.0016759019,-0.01834946,0.008151537,0.03610072,0.036646023,-0.009425295,0.00010741073,-0.019130303,-0.006517916,0.021395018,0.022709738,0.009807174,-0.020126516,0.025615655,0.06431041,-0.017903632,0.050815567,-2.3071525e-05,0.003569229,0.01626618,0.043109782,-0.010220163,-0.09362741,-0.033630718,0.01689967,0.027195288,-0.023574645,-0.042823344,0.00738304,0.012347733,5.4064833e-05,-0.085000806,0.030824868,0.050578028,-0.020786142,-0.023384957,-0.0139338495,0.052340522,0.046665803,0.068542905,-0.010134092,-4.3777444e-08,0.0953684,-0.0087637715,-0.0013133204,-0.07197926,-0.009231251,-0.033580683,-0.020900635,-0.08955515,-0.02818759,-0.044767775,0.01870203,0.058101054,-0.02347702,-0.009572135,-0.04823191,0.054783247,-0.10542241,-0.011601026,0.036364056,0.021978535,-0.0776499,-0.0036371492,-0.10238356,0.010896763,0.025239637,-0.026501218,0.026424479,0.011273161,-5.3218006e-05,-0.02749525,0.082338236,0.023048103,-0.020532662,0.01870875,-0.024025755,-0.0026900203,-0.15004362,-0.044400495,0.066763595,-0.029687274,0.00011222401,-0.033820465,-0.078424335,-0.020209964,-0.107905366,0.009888843,-0.019146552,0.011077273,-0.090127245,-0.024203258,0.038962655,0.040839646,0.007357047,-0.013742216,-0.06363071,0.032851834,0.0051194825,-0.06359174,-0.004486379,-0.0931642,-0.07019578,-0.05565128,0.16974877,0.018659273 +1.5.1.48, The enzyme from the bacterium Streptomyces sp. GF3587 is highly specific for its substrate and forms only the (R) isomer.,384,0.99999994,-0.0032003766,-0.08113042,-0.12761272,-0.025848564,0.061135307,0.031542473,-0.0419725,-0.0012842288,-0.026644576,-0.033547875,0.023392899,-0.034999028,-0.06073774,0.088482834,-0.0006792533,-0.10209704,-0.037902027,-0.0128353685,0.03297215,-0.07597773,0.08017623,0.085582376,-0.025469221,-0.034130063,0.079662144,0.004952274,-0.015574696,-0.01557867,-0.01566456,-0.10301589,0.042669043,-0.054574605,0.10723845,-0.061175294,0.042257376,0.044658113,-0.09102243,-0.06849413,0.11502942,0.025052283,-0.03193281,-0.00017863208,0.02877277,0.059555687,-0.10370106,0.029269917,0.0515174,0.050277192,-0.0011466824,-0.053950846,-0.064544745,-0.058815677,-0.092233226,0.034078673,0.01684475,0.002694965,0.0049651493,-0.050989646,-0.04991313,-0.075111665,0.04893178,-0.043702357,0.03826717,-0.0331423,-0.03842581,-0.022119937,0.052596685,-0.09553143,0.053533785,-0.022150785,-0.06667743,-0.0021658505,-0.06342848,0.010068688,0.011706273,0.075915776,-0.040597606,0.013429695,-0.022254284,0.05400619,0.054678325,0.011535257,0.04016894,0.07782084,0.046617966,-0.034473993,0.03916798,-0.00569845,0.027379295,0.0043838616,0.08182662,0.04014906,-0.008247866,-0.039418165,-0.05697466,-0.01219282,-0.036046162,0.014281195,0.008048977,0.0027825567,-0.05774442,-0.012547741,-0.011643312,0.013608109,-0.049463905,0.012564516,-0.06656295,0.06729076,0.03375193,-0.04267959,-0.027928175,0.06813673,0.0044293026,-0.03341325,0.007693352,-0.027477503,0.06125608,-0.07441878,-0.05759874,0.021066153,-0.0070296917,0.026043866,0.052443877,0.053535696,-0.060589027,0.015256961,-0.15208434,-2.7762456e-34,0.03190841,0.058218203,0.0942297,-0.082920246,-0.012087373,0.010303844,-0.12090441,0.012639772,0.028800022,-0.010315509,-0.086077884,-0.10119196,0.0657476,0.0050601927,0.005797306,0.015936423,-0.009227172,0.060933053,0.028898604,0.0034425142,0.030614479,0.06574383,-0.08000673,-0.036928263,0.038203213,0.058545474,-0.008852979,0.02593034,0.07885952,-0.032489236,-0.019725412,-0.08153741,-0.09102787,0.008533256,0.10677447,-0.05670423,-0.036703482,-0.037557643,0.01277379,0.00034323725,0.0318916,0.026995927,0.047893427,-0.0017457252,0.07934497,-0.039841067,-0.029686663,0.0663222,0.04140629,0.12116623,0.020496896,-0.017847287,0.085042596,-0.0043233847,-0.06358906,0.064304195,0.0125907,0.057419773,0.033718783,0.008609556,-0.018035762,0.09842047,0.016814983,0.014080609,0.035048824,0.08302872,-0.03615853,-0.057464298,0.024132766,0.10345678,-0.04378053,-0.010064043,0.066871874,0.0035314432,0.017352441,-0.04218086,-0.083577745,-0.021989826,0.11122938,-0.0160794,-0.10949811,0.030013489,-0.042359147,-0.086278535,-0.10829959,0.017018631,-0.016709454,-0.047252752,0.025263423,0.07399995,0.023536906,-0.07983355,-0.068405956,0.033066977,0.030899525,-1.4525028e-33,0.1218843,-0.11704689,0.014774866,-0.048966616,-0.053934716,0.0432005,-0.022407657,0.0069257077,-0.029341757,-0.018422712,0.075957075,-0.004248091,-0.034360453,0.0133039,0.016928485,-0.022379551,0.0023878338,0.109691456,-0.020693384,0.060508333,0.0014665509,0.058288664,0.02206222,0.03798453,0.039640125,-0.017613083,0.058766745,0.10948325,0.067289494,-0.00033638993,-0.021138916,0.0028438857,-0.034768436,-0.06302543,-0.05340339,0.035138573,-0.038844142,0.059175845,0.052662473,-0.053284597,0.018457003,0.05628095,0.010525989,0.07395589,0.005692091,0.029305428,-0.014688356,0.021515831,0.03053908,-0.064324304,-0.036140375,-0.003850435,-0.051192727,-0.056777984,0.0022883199,0.07566055,-0.022513898,0.013432359,-0.034912016,-0.011916968,0.01274438,-0.03601978,0.02674288,-0.0065597454,0.093154564,-0.0066653364,-0.009663444,0.03291076,0.053450353,-0.029774865,0.037060782,-0.05761634,0.0030635062,0.08155505,-0.0032811484,-0.064288266,-0.04827925,0.021736016,4.016169e-05,0.0345067,0.08275121,-0.03499067,-0.008764092,-0.031032896,0.013190273,-0.050048426,0.022691894,0.03180157,0.06628003,0.071802296,-0.056480534,0.02550631,0.0054940004,0.045169197,0.06728642,-2.7366937e-08,0.08030435,-0.000381328,0.062513985,-0.06604536,-0.009243163,0.025100097,0.0009675937,-0.1203414,0.0047051734,0.01113582,-0.012915611,0.012385231,-0.021346424,0.0015145695,0.009652817,0.008615858,-0.11239756,-0.028735962,-0.0023047384,0.032447845,-0.10514478,-0.059959296,-0.07730046,0.022026554,0.0407862,-0.07002655,0.052664317,0.07411347,-0.016760267,0.010122211,0.026955867,0.007591617,0.016509103,0.035694536,-0.061483018,0.0022478737,-0.00019821653,-0.010330579,-0.0063826065,0.07201351,0.0051732017,-0.051375866,-0.06582995,0.0049669566,-0.03778821,0.0400263,-0.036913145,-0.020178366,-0.021539468,-0.010188394,0.0494774,0.03865375,-0.07084796,0.044474635,-0.05067754,0.0073807007,-0.014193423,-0.013267454,-0.04269113,0.0019570228,0.034464177,-0.024872677,0.14137186,-0.05824958 +1.10.3.15,"A type 3 multi copper protein. The enzyme, isolated from the bacterium Streptomyces griseus, catalyses an 8 electron oxidation. Activation of the enzyme requires a copper chaperone (GriE). It also acts on 3-amino-4-hydroxybenzaldehyde, giving grixazone A. The second aldehyde group is presumably lost as formate. The enzyme also catalyses the reaction of EC 1.10.3.4 o-aminophenol oxidase.",384,1.0,-0.09053684,-0.046721485,-0.086943105,-0.007213132,0.0819751,0.029945526,0.0057659205,-0.0037057581,0.03750518,-0.07571374,0.022937357,-0.072600506,-0.0694777,-0.0032490364,-0.06201954,-0.03858927,-0.076427706,-0.018263131,0.005067928,-0.05735707,0.051030234,-0.016531548,0.046973173,-0.0386618,0.028485097,0.071672074,0.019724382,-0.024135815,-0.023685906,-0.098895594,0.07118378,-0.025102384,-0.00018456545,0.025912499,0.032104656,0.02776111,-0.06730678,-0.040306047,0.044457078,0.051082604,0.0422262,0.057442036,0.025368866,-0.037204873,-0.02150081,-0.046679482,0.06764163,0.062660605,0.0052636014,-0.028788734,0.0509419,-0.07393792,-0.030967848,0.053791996,0.049032427,-0.013370703,-0.03011344,-0.07156151,-0.01971904,-0.06280616,0.07870392,-0.013963019,0.0020059247,-0.009552756,-0.0038331666,-0.02303217,-0.0033620885,-0.10998292,0.009310818,-0.033148285,-0.06706722,-0.06198312,-0.07467639,0.010297365,-0.035749897,0.07919544,0.09803968,-0.054982804,0.042972315,-0.01554545,-0.0060914755,0.033198003,0.04734908,0.096642345,0.12695362,0.00057666906,0.037410807,-0.01678138,-0.009043997,-0.02457571,0.04963753,0.03268989,0.0018312132,0.0054571475,-0.044209607,0.084497854,-0.017425317,0.011090385,-0.028197553,0.035026446,0.050581172,0.08765602,0.0498416,-0.031389438,-0.0041981474,0.05494165,-0.045407843,0.12555663,-0.016141424,-0.0515109,-0.020662732,-0.011756542,-0.013481799,-0.021754928,0.02208956,0.07496259,0.06575583,-0.03751422,-0.061604932,0.006082514,-0.004148022,0.0046713334,0.025467087,-0.033390496,-0.03335785,0.03631763,-0.0900798,3.4502302e-33,0.014885992,0.05295337,-0.033699226,-0.06248762,0.09661981,0.029367724,-0.109366216,0.08916437,-0.016516479,0.0071817525,-0.08255695,-0.044363506,0.053811755,0.0010339062,-0.0058746687,0.014279331,-0.051679187,0.019059977,0.08051588,-0.0601313,0.044988267,0.042651355,-0.022779796,-0.003404453,0.028655706,0.028788153,-0.005431765,-0.005799563,0.043062866,-0.022805126,0.02437853,-0.062338855,-0.05168048,-0.0146482205,0.0010408392,-0.014789313,0.0106111895,-0.058611464,0.0688771,0.0764637,-0.016571127,0.026373137,0.022553151,-0.01556511,0.051859066,-0.046295356,-0.049974613,0.08243603,0.025416568,0.019198451,0.062457632,-0.037108816,0.101243764,0.023862954,-0.092299365,0.03495982,-0.033737946,0.06321851,0.12808967,-0.026210032,0.054039005,0.08273914,-0.01715789,-0.01604967,-0.0073433965,0.047080465,-0.02152958,0.00048561164,-0.006120745,0.099341564,-0.09629346,0.009660136,0.036274325,-0.035011742,0.055728685,-0.023811633,-0.11037696,-0.07332364,0.09848681,0.04269184,-0.07927029,-0.005977804,0.042037733,-0.027267935,-0.050643668,-0.05237505,-0.07094204,0.0021979236,0.025701363,0.016089471,0.03051154,-0.015731988,-0.087944455,-0.013967162,-0.0076851686,-2.6182656e-33,0.07327005,-0.06210974,-0.023829699,-0.09165558,-0.020575443,-0.028475882,-0.052856494,-0.023310464,0.0069606546,-0.025179232,0.09957089,-0.033632714,0.06887261,-0.06498194,0.097693905,0.005563838,-0.09583148,0.08629719,-0.0033640552,-0.0039558304,0.028659381,0.041717514,-0.018575173,-0.0037372035,-6.537948e-05,0.020902954,-2.418349e-05,-0.012126606,0.09701669,0.028464906,-0.05492386,-0.019141218,8.9621506e-05,0.02107085,-0.033744413,0.053816035,-0.010428646,0.042433385,0.055744126,0.027386716,0.07510789,0.023226025,0.041374605,0.16141382,0.091353275,0.0769783,-0.076702245,0.0073484597,-0.034823284,0.039806742,0.039263003,-0.0029554327,-0.026669972,0.009755722,0.032405723,0.053495426,0.011466851,-0.09141589,-0.05709326,0.048372358,-0.054316442,-0.05658632,0.0016917516,0.021428809,0.044239454,0.017906195,-0.09423854,0.11735698,0.019047065,-0.032735717,0.06793682,0.019669583,-0.04443614,-0.02418548,-0.007155134,-0.027175715,-0.05450659,0.046939284,0.054840744,-0.009990767,-0.019795526,-0.00014125447,0.06361165,-0.02704682,-0.026345318,-0.07116784,0.021684282,0.1429375,0.0453922,0.019221421,-0.03458658,-0.03194587,0.03204702,0.071395636,0.03404726,-3.728309e-08,-0.023933306,0.0031675065,0.09141179,-0.041140385,0.025047977,0.044344205,0.030563263,-0.026597885,0.049211133,-0.029091042,-0.0036064635,0.046190668,-0.042444296,-0.024145547,0.03951002,0.08462581,-0.0588953,-0.051203355,-0.005095852,-0.04250518,-0.07265208,0.031266846,-0.04647069,0.05335583,0.0008341279,-0.010819178,0.0028778308,0.025839245,-0.14565593,0.029063381,-0.030052269,0.04671145,-0.038372084,0.015376779,-0.054119624,0.0013309123,0.0064938427,-0.03339726,0.020376766,-0.038832046,-0.050953787,-0.07832723,-0.08420903,-0.029921116,-0.018376948,0.0028412372,-0.030485654,-0.0321325,-0.005437409,-0.014635156,0.04275343,-0.02962028,0.017417753,-0.0018175608,-0.10745297,0.030074058,-0.060809273,-0.078840874,-0.056318596,-0.05640152,0.02932796,-0.025477543,0.15893048,-0.009341883 +1.11.1.23,"This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate [7].",384,0.99999994,-0.00047254082,-0.013675049,-0.16201094,0.022658575,0.05656975,-0.018194284,-0.035257332,0.081444755,0.04998366,-0.048164275,-0.03323713,0.012011814,0.053087376,0.04772529,-0.06930211,0.012924446,-0.051055845,-0.006346811,-0.015069757,0.0128711,0.032976307,0.08574272,0.03787488,-0.02770528,-0.008638452,-0.030934578,0.005630833,0.045150183,-0.07076139,-0.06763151,0.06928662,-0.007081326,0.09617845,-0.0516475,0.09231476,0.0794086,-0.00068643765,-0.06203639,0.10519646,0.022009404,-0.044075888,-0.059554167,-0.0188055,0.018691372,-0.021921271,0.019071672,0.06215664,-0.009496381,0.048174158,0.035916243,-0.05930923,-0.040726963,-0.07139993,0.057868883,0.078461096,0.070018426,0.028073872,-0.059894934,-0.034654707,-0.019446932,0.07025446,-0.04773831,0.004425439,0.04842476,-0.07617581,0.0006767242,0.026426738,-0.08017616,0.015222843,-0.08859091,-0.05812043,-0.017440952,0.009279799,0.006336673,0.008315297,0.006893014,0.035049655,-0.04556017,0.004794338,-0.021894008,0.025493557,-0.0007511925,0.043948185,0.10280546,0.032261066,0.019759174,0.019458327,-0.042390034,0.0115622915,0.109177485,0.015138979,-0.0028806108,-0.04852661,-0.063812114,-0.03865819,-0.0064627486,0.004777398,0.030228604,0.012668437,0.013615122,-0.041820318,0.0020182042,0.019431531,-0.03575718,0.021092458,0.0022960033,-0.010202823,0.09028319,-0.0016847127,-0.027368613,0.00259986,-0.009260153,0.009821333,-0.047102608,0.00043604983,0.053681303,0.12041604,-0.0414045,-0.06811777,0.008117196,0.057320762,0.06416964,0.008176947,0.02903644,-0.033179995,-0.014430365,-0.07084333,7.5506284e-35,-0.022487948,0.10961102,0.01688866,-0.058252186,0.036086343,-0.014463046,-0.10531548,-0.0431521,0.019101366,0.008847932,-0.102954306,-0.081161335,-0.014409293,-0.0026373542,-0.022036608,-0.06745911,0.001352232,0.051993147,0.007871585,-0.00046797888,0.10746163,0.04850041,0.008515582,-0.044196233,0.04355899,0.10979216,0.0042409026,0.030806983,0.06792796,-0.019084869,0.012149998,-0.034659117,-0.070735864,-0.05201795,0.07572593,-0.0594904,-0.048839748,-0.051714156,0.040866613,0.034010045,-0.021055816,0.016879914,-0.043943387,0.0013311884,0.07631692,-0.08141026,-0.08442145,0.06497166,0.048669517,0.076279595,0.011409961,-0.056063663,0.059023723,-0.013388853,-0.088850364,-0.020869322,-0.034264755,0.0452958,0.05678305,0.054327648,0.010997172,0.044484675,-0.019010525,0.0344398,0.039112017,0.011141603,-0.008167668,0.0074438215,0.04090044,0.0642708,-0.0294291,0.05109327,0.035597045,-0.0075203557,0.03801324,-0.020712448,-0.08338402,-0.05542983,0.08134576,-0.011245018,-0.007085687,-0.018797556,-0.037504774,-0.01802644,-0.021007108,0.065987185,-0.028109353,-0.050212055,0.01241683,0.01966968,-0.04349898,-0.089363985,-0.05980258,-0.04587659,0.014897213,-1.934022e-33,0.09303903,-0.06747291,0.098722234,-0.073238105,-0.05060226,0.06670882,-0.050584935,-0.000565571,0.01901331,0.02449757,0.07104265,-0.05395027,-0.038478136,-0.08444483,-0.011051406,0.025676614,-0.017426977,0.06724329,0.002217124,0.025457112,-0.0038466011,0.026943311,0.005269231,0.04992881,0.05980217,-0.0058536036,-0.029409159,0.01257787,0.04723328,0.0916346,0.014419236,-0.06926279,0.0119979335,-0.078068554,-0.03191816,0.070267946,-0.059184432,0.045211636,0.06500484,-0.017950086,0.07286127,-0.04747397,0.03863417,0.059377827,-0.027473224,0.043071155,-0.17334843,0.07492906,0.052504305,-0.052316718,-0.011582569,0.021326113,-0.030449625,-0.012274777,0.0052579865,-0.022778368,0.032446083,0.0277631,-0.050998032,-0.031059839,-0.060260806,-0.06048572,0.03963312,-0.00026505013,0.09558072,0.034682658,-0.019270437,0.05115943,0.039879702,0.0042031463,0.071096264,0.0274349,-0.033797354,-0.007259788,0.050652854,-0.015744809,-0.02605243,-0.029797425,-0.015392765,0.10856153,0.04000691,-0.0119413035,-0.0063549154,-0.025885597,-0.009630552,-0.096627235,0.03502139,0.036943708,-0.022569673,-0.03289129,-0.013575205,0.037377194,-0.03790854,-0.03483604,-0.011199498,-3.4091745e-08,0.030811872,-0.025201092,0.044775374,-0.06358989,0.014927197,-0.043255817,-0.034616012,-0.066840515,-0.009958252,0.0066839578,-0.003446131,0.12557653,0.01845075,-0.0815765,-0.0036677357,-0.0024376689,-0.03413394,0.016110597,0.029184308,-0.014810453,-0.06502783,0.013988929,-0.1099936,0.005815497,0.059370577,-0.051269334,-0.013275854,-0.06163072,-0.007328545,0.015433549,0.0931182,0.02949635,-0.05003299,0.0034386115,-0.11487081,-0.013144111,-0.072310634,-0.032234363,-0.04667176,0.022102201,0.026041707,-0.01698119,-0.039420217,0.0080768475,-0.11180732,0.0443958,-0.0043999474,-0.013284221,-0.0604571,-0.034896336,0.08234898,0.036916576,-0.015648585,-0.0064291516,-0.13734142,0.09794699,0.027869973,-0.041553274,-0.023517217,-0.044146836,0.01344242,-0.06192027,0.21203119,-0.058746196 +1.11.2.5,"The heme-containing peroxygenase from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family. ",384,1.0,-0.086288296,-0.010679606,-0.17554194,-0.022097139,0.02656902,0.04577114,-0.10565191,0.09299972,0.06198555,-0.039531082,-0.0034689184,-0.016012358,0.1003346,-0.0009775471,-0.03650254,0.036196213,-0.07669206,-0.0069005815,0.044347614,-0.07352626,0.024579829,0.109091535,0.032813918,0.021012751,0.09382218,-0.005606743,-0.018895812,0.011685949,-0.07021559,-0.039326232,0.12739083,-0.0029630067,0.06729262,-0.067685485,0.08194176,0.07130498,-0.064173535,-0.016177768,0.07337745,0.028713778,-0.048306502,-0.037093606,-0.025826123,0.0266913,-0.08659058,-0.025398055,0.019503498,0.018404821,0.023092408,0.040788874,-0.055970885,-0.07917215,-0.0917219,0.042545345,0.033422165,0.036749467,0.022711989,-0.0214046,-0.003171269,-0.03176979,0.0180474,-0.032111786,0.017779155,0.06252654,-0.09229204,-0.07291988,0.055116322,-0.0880939,-0.011478153,-0.07345589,-0.04323587,-0.04974553,0.009986608,0.05180762,-0.046914402,0.02866696,-0.005736949,-0.017685711,-0.02404349,-0.015178305,0.029342879,-0.025783801,0.037408084,0.10767496,0.043350123,-0.014413706,0.028705716,-0.027659498,0.060853973,0.0621682,0.027610622,0.011044951,-0.02217141,-0.08249682,-0.007658197,0.019773223,0.0023374732,0.03296383,-0.00096581737,-0.037237123,-0.01457078,0.03706567,-0.018481022,-0.0006283281,0.035321243,-0.0024032097,-0.04507615,0.051897984,0.02944173,-0.06361259,0.020798163,-0.03149281,0.04393783,-0.043465666,-0.025417851,0.067888305,0.14045317,-0.026869636,-0.097006544,-0.02918497,-0.027173545,0.034163956,-0.0059267036,-0.053202305,0.040416706,-0.011104453,-0.082414754,3.5463687e-33,0.044445265,0.060497,-0.049326975,0.0038459322,0.011900434,-0.02015497,-0.119392976,0.034367874,0.012396968,-0.019421319,-0.11526048,-0.037767686,0.0058427574,0.026114069,-0.000727362,-0.0033988918,-0.019396823,-0.03151385,0.025087874,-0.02021893,-0.0144808665,-0.00486946,-0.0088698305,0.025488583,-0.019966586,0.09561056,0.0482278,0.05517223,0.0165315,-0.0032328062,-0.017575495,-0.024831373,-0.070395656,-0.065994136,0.0815766,-0.048843823,-0.085898034,-0.00906346,0.008068525,0.09625959,-0.017505977,0.04900157,-0.0071307947,-0.06008732,0.07971671,-0.078916684,-0.04445638,0.08394401,0.07419308,0.10866224,0.050184943,-0.04654044,0.09033482,0.0029473875,-0.08411954,0.028452752,-0.03782254,0.07400299,0.062081322,0.056485757,-0.0031293177,0.025657067,-0.00071095244,0.0047593364,0.07426792,-0.012939158,-0.020279236,-0.030199306,0.0042679673,-0.0024513537,-0.004317157,0.041021567,0.028523011,0.029763348,0.017860314,-0.003842526,-0.06743477,0.041144595,0.10150315,-0.0305807,-0.032076385,0.015354341,-0.009103623,-0.056670725,-0.032087993,-0.0028752976,-0.03399725,-0.040836297,-0.035866085,0.003442598,-0.011111164,-0.13662952,-0.047936894,-0.028058248,0.047647096,-4.707405e-33,0.08488383,-0.049915694,0.070390254,-0.07143612,0.011701472,0.09948068,0.016301563,0.032458358,-0.01579784,0.04228443,0.053894706,0.06233984,-0.02135059,-0.07318425,0.062024772,-0.028363373,0.057292137,0.021000227,-0.057879344,0.03263248,0.044449467,0.06598401,-0.002813174,0.010907109,0.05093817,0.010047884,-0.012561276,0.0047065015,0.018148955,0.07549202,-8.033926e-05,-0.034638982,-0.02105073,-0.041477986,-0.03154025,0.05957463,-0.032017145,0.09080959,0.038339805,-0.025700707,0.08081978,0.036904577,0.025698088,0.072118714,0.017516932,0.04446382,-0.16456023,0.0021569838,0.01613515,-0.079623535,-0.042685475,0.034907997,0.020990508,-0.033985857,0.021796128,-0.041111823,-0.0068932693,-0.042211264,-0.014352726,-0.07584009,-0.037531972,0.013478443,0.028640928,0.026290588,0.012694957,0.061750248,-0.060554083,-0.006488488,0.057091773,-0.033657998,0.030890172,-0.00523818,-0.03150068,-0.0026264258,-0.006314071,-0.04481746,-0.029375937,-0.033694394,0.035847146,0.031482033,0.027031172,-0.014645924,0.03391281,-0.06688697,-0.004223784,-0.05913206,-0.010057364,0.02627877,0.027988696,-0.038786486,-0.009576621,0.08372471,-0.0083386,0.028019607,0.08919914,-3.2298317e-08,0.028567364,-0.048449274,0.0924355,-0.0031975843,0.04117276,-0.040347233,-0.04164763,0.01410662,0.03208822,-0.0064389175,0.0074819657,0.07593825,0.019424997,-0.0495006,-0.0031782892,0.08127767,-0.02163094,-0.016522828,-0.0015429473,-0.004799964,-0.0453859,-0.008461475,-0.04146681,0.05099231,0.062137548,-0.084943384,-0.043030176,-0.035604406,0.0034216652,0.019426681,0.04387082,0.009382782,-0.045623247,-0.033298984,-0.061567515,-0.07553216,0.018502684,-0.07354807,0.05236886,-0.017813476,0.028579509,-0.0049106395,-0.07327575,-0.0007734736,-0.048412874,0.055400025,-0.0075852303,-0.012471966,-0.11084357,-0.014479688,0.04785594,-0.02082423,-0.037370898,0.015993064,-0.12446496,-0.040066253,0.025802912,-0.07177794,-0.041434027,-0.097243205,-0.03288489,0.008606619,0.21269205,-0.049328767 +1.13.11.78,"Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway.",384,1.0,-0.041796755,-0.04139679,-0.022887528,0.01462572,0.0704979,0.014577424,-0.050104663,0.014492987,-0.013923242,-0.031887032,-0.069195785,-0.053941958,-0.024345933,0.060164634,-0.045574054,0.008004848,-0.09305695,-0.015186159,0.010438188,0.04418512,0.06582952,0.054818206,-0.015857166,-0.07081561,-0.022235252,0.048529103,0.023054691,-0.03755116,-0.029707987,0.00064552645,0.0020560147,0.028649237,0.0937675,-0.13886277,0.040496334,0.12043299,-0.020964717,-0.075180456,0.01133541,-0.017827066,-0.058395877,-0.0028601906,-0.00987873,0.005668965,-0.06295974,-0.091931306,0.058554806,-0.03613654,0.041957654,0.0561709,-0.06619589,-0.049036674,-0.023134097,0.025222348,0.033536736,0.045138564,0.007273897,0.0064404774,-0.08022839,-0.033086423,0.04988609,-0.031571843,-0.029064247,0.042293698,0.04337344,0.0054999506,0.09651724,-0.06683465,0.0059350757,0.034366474,-0.048149332,-0.027502654,-0.02940952,0.003608888,-0.02009773,0.028176585,0.0809201,-0.07452981,0.08926856,-0.018221779,-0.03535366,-0.051283665,-0.002272153,0.021441832,0.0478091,0.04717104,-0.010606356,-0.06903959,-0.045520213,0.08720461,-0.01718334,0.0020370628,0.032271132,-0.07042841,0.020680543,0.045125388,-0.015522652,0.03163166,0.034587473,-0.0039568283,-0.053994,0.082681075,-0.0059597916,-0.08406781,-0.009173138,-0.052328013,-0.060165167,0.10582782,-0.032589678,0.010999559,0.022193814,0.028980035,0.054804664,0.03547199,0.03749356,0.10673379,0.035606936,-0.06657757,-0.07189843,0.05117826,0.033613972,-0.014071626,-0.016196402,0.044028327,-0.085485525,0.027814241,-0.096787885,-1.8112632e-33,0.0781457,0.008345473,0.015042322,-0.041109633,0.029154062,-0.005816472,-0.107677914,-0.026533017,-0.010418504,-0.056009587,-0.041128866,-0.06671111,0.025841622,-0.027187362,0.029753232,-0.039844386,0.021564748,0.011066049,0.05014085,-0.03196669,0.055186175,0.06490281,0.05193749,-0.029304607,0.07555131,0.05037259,0.0090631265,-0.013502531,0.0026217285,-0.0037408464,0.03441101,-0.13456738,-0.12657236,-0.023528019,0.11434404,-0.036369685,-0.01243027,-0.027709562,-0.05113174,-0.020566834,0.006063551,0.09189903,-0.014708979,-0.009967366,0.09995946,-0.10152657,-0.0332897,0.1353153,0.013975311,0.09861024,0.03892221,-0.009674818,0.036623646,0.0032266153,-0.05493993,0.019531278,0.04630223,-0.026441477,-0.009763614,0.03145292,0.0071592596,0.040784154,0.079697974,0.06618839,0.10056211,-0.00079543504,-0.04273805,0.028205708,0.022329547,0.08786061,-0.04963031,-0.008649963,0.057220247,0.053004954,0.014446047,-0.08913763,-0.06797072,-0.06715854,0.09648496,0.045532785,-0.0016968669,-0.02634814,-0.0035605275,-0.029998546,-0.0688138,-0.017335286,-0.015146602,-0.05452465,0.02682127,0.04393731,0.026380006,-0.051838595,-0.08573108,-0.015944783,-0.018311994,-1.0740357e-33,0.044927135,-0.050613154,0.042949338,-0.042176574,-0.06612653,0.06070936,-0.0052195876,-0.04811491,0.021455728,-0.0042113927,0.036940455,0.029149614,0.053450424,-0.08543144,-0.01606665,0.0022805913,-0.01813166,0.060015596,0.038106997,0.00034566605,0.043589726,0.06566211,0.022552148,0.042807426,0.04613411,-0.013389888,-0.0813637,0.04776296,0.009672606,0.07807191,0.0035121304,0.048426118,-0.04497977,-0.109508604,-0.045335785,0.03195707,-0.013075081,0.024070581,0.061807122,0.0066077258,0.04704884,0.04522296,0.045425896,0.05092504,-0.036506277,0.021952266,-0.021268958,0.03913161,-0.021120578,-0.04091703,0.0072389664,-0.0626142,-0.036981132,-0.0017702029,0.023539744,-0.008211277,0.02318607,0.025652217,-0.040703256,0.03239734,0.005814801,-0.054993965,0.05380657,-0.017805738,0.02430384,0.02927741,0.008651849,0.10669822,-0.005393043,-0.0005546809,0.07169572,0.05241571,0.062465716,0.054277472,-0.015626399,-0.031754844,-0.13646854,-0.005780486,-0.017813334,-0.020368025,0.019764833,0.07356832,-0.03768254,-0.05434942,0.022168329,-0.13278165,0.0460787,0.027724829,-0.03755384,-0.017718235,-0.04761018,-0.020526024,-0.09211562,0.014008247,0.008840409,-2.6008513e-08,-0.0107010035,-0.0074205017,0.05752312,-0.0694784,0.012477881,-0.011782154,-0.0073246635,-0.0030046813,0.029645838,-0.07174781,0.0004029262,0.07318391,0.037756864,-0.010755609,0.018809116,-0.0076908004,-0.0071589765,0.0409418,-0.06511774,-0.05332752,-0.08702128,-0.017669814,-0.09763889,0.05823609,0.014954925,-0.014731528,0.020465521,0.031380467,0.02294311,-0.028718939,-0.005322239,0.026697762,-0.065272234,-0.044687852,-0.12138414,0.004868599,-0.035641495,-0.06339884,-0.0666912,0.06399402,-0.066205606,0.093134485,-0.07600969,0.019122727,0.014187906,0.008731761,-0.01184661,0.06809946,-0.059943046,-0.008164231,0.09345281,-0.04062851,0.024966376,-0.07264378,-0.08217546,0.09523566,0.024334159,-0.0074787233,-0.0036708454,-0.005434636,0.017772838,-0.031603422,0.1782642,-0.07261434 +1.13.11.79,"The enzyme catalyses a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12. This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor [4]. The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet.",384,0.99999994,-0.07125154,-0.02980007,-0.15053177,-0.002007865,0.0716009,0.0103495885,-0.007862797,0.06067799,0.018021079,0.029726494,-0.014963074,0.025642782,-0.05290445,0.039094478,-0.06500374,0.027221723,-0.050565723,0.07136596,-0.08035687,0.0137248505,-0.016156664,0.02632346,0.08854287,0.009558212,0.010161956,0.0135577675,0.048279956,0.00039767657,0.0053719105,-0.06342891,0.033199064,-0.0611696,0.09227913,-0.01697646,0.03685665,0.034775075,0.057604637,-0.04396383,-0.029214293,-0.0074132863,0.027534481,0.014244201,0.054046523,0.024947884,-0.022448886,-0.03373729,0.014960388,0.040494177,0.038589638,0.059317835,-0.067103826,0.0192222,-0.10166891,-0.051044174,-0.0020146999,0.05967829,-0.05596125,-0.015896467,-0.031416483,0.045175802,0.044724856,-0.017490188,-0.008525857,-0.0036405541,0.019157602,-0.018463647,0.035663653,-0.061154168,-0.0025231068,-0.09363414,-0.025470108,-0.043532867,-0.033264562,-0.021185912,-0.011784828,0.035546996,0.0076271896,-0.008881083,0.028174095,0.02895319,0.006363794,-0.0011641459,0.004805089,0.08601328,-0.0063276193,0.014378788,-0.066861756,0.08983739,0.020630652,0.06461998,-0.005957838,0.036129136,0.08903893,-0.0084615,-0.074191384,0.08277237,0.035188314,0.0729565,0.040821575,-0.013104364,-0.0038799788,0.036263883,-0.02507821,-0.060463365,0.0026438767,-0.034921404,0.0045293006,0.080561005,0.027080003,-0.025278091,0.050454553,0.011887011,0.04163376,0.023222826,-0.04022668,0.08840088,-0.031382307,-0.03096227,-0.0764785,0.0065882336,0.0067362585,0.036774687,0.10660929,-0.019706197,-0.052091062,-0.006500809,-0.070892066,4.5502365e-33,0.04611204,0.060191847,0.015816813,0.05296429,-0.040045824,0.012170539,-0.057966605,0.026841627,-0.052986618,0.0049357275,-0.12995651,-0.055572208,0.05941532,-0.0056802286,-0.05756328,-0.06249318,-0.0029331106,-0.065248325,0.086512335,0.052039742,0.04685241,0.04457651,-0.011999286,0.0604952,0.057202265,0.010952741,0.021344034,0.067863286,0.07743707,-0.008322694,-0.03192861,-0.14219606,-0.11507303,-0.021157596,0.080251604,-0.042293474,-0.06591357,0.049084403,0.0076676863,0.056732494,-0.050045464,-0.020881549,-0.1112826,0.04223005,0.10917355,-0.012345716,0.022581415,0.043849565,-0.007233963,0.024290668,-0.012955978,-0.02316505,0.097495414,0.015163831,-0.08766227,-0.034388386,0.015883459,0.00045507506,-0.0053912723,0.051805563,-0.006399787,0.055216525,-0.0098324455,0.056620672,0.0072067585,-0.021574952,0.0067494907,-0.09603933,-0.004614539,0.03936199,0.096007645,-0.0703076,0.078726746,-0.0037599744,0.049665388,-0.03791064,-0.047266837,-0.047511667,0.06296401,-0.019821981,0.0017540168,0.070455566,0.017414792,-0.00021024371,-0.0786853,-0.02740881,-0.05114981,-0.0849336,-0.010642906,-0.019375673,0.042055313,-0.13203855,-0.0030607048,-0.11004571,0.04834059,-3.8223958e-33,0.07568491,-0.04162517,0.007600097,-0.027914397,-0.022922223,0.030286249,0.08310879,-0.08636114,0.035926517,-0.0019681086,0.09993938,-0.053397693,0.012524694,-0.038635403,0.0038077796,0.049800564,-0.030621,0.07109981,-0.0039766403,-0.0025970065,0.008515814,0.060893904,-0.017048957,0.0049691973,0.0063958378,0.034839686,0.07222457,-0.005077796,0.04060367,0.115413256,-0.04589008,-0.007711395,-0.07380843,-0.026168656,-0.05627591,0.07576814,-0.02904996,-0.00020580305,-0.094036266,-0.0020287463,-0.048130956,0.003097557,0.018029109,0.0053987433,-0.0010105493,0.061430156,-0.09100861,-0.00055755983,-0.022787206,-0.034130342,0.03775617,0.044815216,-0.031131914,0.045554467,0.037372418,-0.007369889,0.0850956,0.03112888,-0.014316739,-0.04855557,-0.030375868,-0.13846193,0.078147195,-0.022919152,0.039300513,0.039077457,0.052507404,0.07642464,0.03233585,-0.06472795,0.038961124,-0.06839052,0.10550277,0.014663246,-0.025156438,0.029894305,-0.004639661,-0.01535806,-0.012252319,-0.036905862,-0.009437218,-0.05438599,0.017406438,-0.020190643,0.024558237,-0.09665833,0.06320253,0.042693604,-0.046206053,0.11647351,0.011282137,0.051063024,-0.029020306,0.027588177,0.07593851,-5.043363e-08,0.022396771,-0.07545341,-0.034214884,-0.053850934,0.017068213,0.04526141,-0.057965398,0.01145717,0.07601892,0.01784533,-0.030629518,0.06285538,0.0122167375,0.009861428,0.030329337,-0.0078034876,-0.06676666,0.011485191,-0.024218757,-0.002867353,-0.05632278,0.049397644,-0.15618093,-0.07986901,-0.010713228,-0.064920865,-0.079109706,-0.007210257,0.08897194,-0.047897886,0.053297255,0.019994522,0.006942302,-0.06037432,-0.078123406,-0.07174,0.062301558,0.0037784812,-0.04836804,0.02497459,-0.049249157,-0.055114515,-0.074876264,0.06829599,-0.028391467,-0.006823133,-0.0106153255,0.08257759,-0.033296924,0.06607366,-0.00024468923,0.008605762,-0.049321517,-0.07907863,-0.07902809,0.061015096,-0.012600576,0.0036049641,-0.03733534,-0.0082691945,-0.02198863,0.014834163,0.084536344,-0.04753733 +1.14.11.45,"The enzyme, characterized from the bacterium Bacillus thuringiensis, can also catalyse the hydroxylation of L-leucine, L-norvaline, L-norleucine, and L-allo-isoleucine, as well as the sulfoxidation of L-methionine, L-ethionine, S-methyl-L-cysteine, S-ethyl-L-cysteine, and S-allyl-L-cysteine.",384,0.99999994,-0.043802787,-0.03982241,-0.02072238,-0.04353952,0.068242185,0.09077871,-0.110734336,0.049760647,0.004849678,0.009792264,0.025310293,-0.0586291,0.047095094,0.0010315458,-0.058958784,0.10272236,-0.064066865,0.06723954,-0.0064637866,-0.04735343,0.056553587,0.09760092,-0.09207241,0.0030028287,0.05856445,-0.015406573,0.02050216,-0.06750693,-0.040575173,-0.07370982,-0.026901579,-0.054436713,0.0027884557,-0.023827486,0.06510841,0.05079387,-0.07604361,-0.016263658,0.096695,-0.046449997,-0.034120385,-0.032837253,-0.005422829,-0.08376686,-0.03456589,0.015991691,0.025015848,0.03628037,0.02151264,-0.08102527,-0.018042376,-0.03577366,-0.07332932,0.05542006,-0.015126798,-0.059566036,-0.043548718,-0.016230514,0.008425047,0.06679773,-0.0055734604,0.03187623,0.008649112,-0.004152868,0.06065103,-0.069481954,-0.018252239,-0.027251845,-0.0013426408,-0.01079964,-0.010770517,-0.07698249,0.0072615244,0.030140806,0.014688709,-0.03156935,-0.039751213,0.039066993,0.08451588,-0.039038364,0.0027275188,-0.0019286354,0.002594797,0.13120717,0.035346232,-0.04304427,-0.021789825,0.03845999,0.12798043,0.022455536,-0.0008147047,-0.0038194912,-0.08696404,-0.0061213677,-0.052171946,0.018539114,0.007046569,0.059578363,0.0024457283,-0.04087389,-0.0036101283,0.027731672,-0.13030356,-0.11741391,-0.061008878,-0.0367812,0.104435295,0.08685625,0.06639946,-0.036280233,0.014295331,0.0363302,0.036819864,0.019417215,-0.08967679,0.0070704003,0.08384768,-0.081217185,-0.049475033,-0.066355206,0.016397571,-0.04075671,0.015382437,0.049461525,-0.0026345463,0.01863481,-0.03432504,1.2168531e-33,0.06467821,0.056117207,0.00014545514,-0.016569968,-0.0007283799,0.011490352,-0.06724336,0.06597283,-0.028344067,-0.061396796,-0.08897846,-0.0643553,-0.027153105,0.052747462,-0.03630813,-0.0005470461,-0.00020829159,-0.025770057,0.07165466,-0.04295866,0.005183667,-0.041436248,-0.037016783,0.03507388,0.019672139,0.021856703,0.086935915,0.041130576,0.0057204883,-0.018071182,0.018787056,-0.088056006,-0.008300677,0.0022283231,0.0489204,0.04212331,-0.055920783,0.04024172,0.0006472374,0.095113285,0.0032992894,0.04688982,0.008682025,-0.08227636,0.0148119135,0.010817628,-0.06423357,0.08661514,0.021502338,-0.0021861643,0.05580621,-0.05841423,0.05906308,-0.06551801,-0.04387834,0.031186415,0.017875852,-0.021877645,-0.028366966,0.041581374,0.017536541,0.07449153,-0.0075357263,0.024456792,0.025733212,-0.01087958,-0.017022563,-0.0104648005,-0.020119056,0.0038330366,-0.083663054,-0.03115802,0.10465329,-0.012999056,-0.024612656,-0.013974872,-0.07155248,0.03643624,0.091617845,-0.0046454873,0.037646238,-0.06451267,-0.0039799875,-0.007809911,-0.0061205835,-0.03393405,-0.04600869,-0.056024153,0.029006287,0.06529648,-0.009935674,-0.1236107,-0.06365608,0.013941966,-0.031657416,-2.3757909e-33,0.042205025,-0.092761494,0.09776871,-0.07874768,-0.016594633,0.009192445,0.010844916,-0.008701589,0.0660569,0.028313302,0.0429208,0.028119132,0.028497446,-0.029695604,0.035113577,0.0007007734,0.06182634,0.05439265,-0.013289196,-0.002662229,-0.020460408,0.06370168,-0.022109592,-0.02422823,0.056906607,0.05081801,0.040629577,0.12484289,0.10447539,0.036271155,0.04772706,-0.009880463,0.036368392,-0.08725211,-0.021288358,0.11576445,-0.011074803,-0.0017310972,0.07246983,-0.043832537,-0.0055790036,-0.029839525,-0.024246067,0.007100794,0.07091857,0.019001452,-0.07811514,-0.056006644,-0.008352365,-0.041506913,0.07065398,-0.024096992,0.029843455,-0.03853823,-0.025477754,0.03534666,-0.025200462,-0.019085286,0.06308136,-0.11933071,-0.034401458,-0.07025817,-0.012993762,-0.026131356,-0.032444738,0.096089184,-0.08505106,0.033451125,0.02430962,-0.007237285,0.011245728,-0.028205134,0.0037857932,0.025348429,-0.09142659,-0.017426318,-0.032061964,0.016736623,0.005608964,0.02296182,-0.010837707,0.013697493,-0.013325118,-0.10062043,0.027387604,-0.006204942,0.0067499937,0.15453002,0.045088824,0.012014845,-0.06433277,-0.0073600956,-0.022448787,0.028664334,0.059218343,-4.7473172e-08,0.0007690324,-0.14565961,0.01780864,0.0135337105,-0.023976851,0.030249774,0.063483745,0.01870224,0.0635529,-0.02696781,-0.03596668,0.10430253,-0.021040088,-0.032181956,0.052684467,0.0054362444,0.0059665246,0.0038317076,-0.023768408,0.03719609,-0.03997405,0.009977314,-0.08464396,0.020013804,0.02493456,-0.09698883,0.032320224,-0.06125107,0.0029431481,-0.030616812,0.0023675587,0.034685276,-0.0037246943,-0.043731567,-0.050421514,0.013884605,-0.09246308,-0.040690154,0.04687643,0.031891294,0.023191292,0.08548368,-0.091559865,0.05050347,0.036782857,-0.030865673,-0.02240315,0.075391285,-0.036604516,0.018953353,0.054316502,-0.047673743,-0.032581225,-0.0717903,-0.0680017,0.016288623,0.03684137,-0.03874182,-0.023157006,-0.027967345,0.027968312,-0.006466922,0.20045404,0.0009008636 +1.14.11.46,"Requires Fe2+ and ascorbate. The enzyme, characterized from an uncultured marine bacterium, is involved in a (2-aminoethyl)phosphonate degradation pathway.",384,1.0,-0.057737373,-0.026750218,-0.06387159,0.057714913,0.04552223,0.020605668,-0.048029587,0.009859216,-0.021690099,-0.024723409,-0.03452044,-0.04398872,-0.061987713,0.058556113,-0.045341004,0.016642006,-0.06666533,-0.018377071,-0.010632878,0.03337518,0.1064299,0.0855496,0.00047326702,-0.03908295,-0.016706273,0.008172581,0.013158022,-0.049181845,-0.032739185,-0.0377046,0.0036973977,0.004202448,0.10451136,-0.12043484,0.05000797,0.10775383,-0.019641722,-0.083940096,0.035402764,0.020609641,-0.028321756,-0.0017138277,-0.007067074,0.024704356,-0.047979217,-0.07975617,0.043228466,-0.016173195,0.04009742,0.037822954,-0.07475457,-0.022280449,-0.021644864,0.0113816345,-0.036175493,0.076912805,-0.021592489,-0.008211737,-0.077339925,-0.020771535,0.025144946,-0.0013442718,-0.024310574,0.022675527,0.015506576,-0.010012061,0.06837381,-0.055040598,0.005565673,0.034015436,-0.04279348,-0.04633533,-0.0052001905,0.040506106,-0.0002650535,0.02867607,0.05978521,-0.042052563,0.054763265,-0.028352112,0.005215363,-0.07292393,-0.0054399003,-0.0073648007,0.042496968,0.045060564,-0.024267495,-0.0348964,-0.015721733,0.118078254,-0.015981946,0.01644136,-0.0027209804,-0.083715335,-0.009144523,0.020211581,0.030384611,0.027422093,0.047703493,-0.011576318,-0.037704542,0.085076034,-0.009046485,-0.08092662,-0.0015452158,-0.05060532,-0.07476359,0.071556814,0.015125003,0.003481662,-0.000947878,0.03760458,0.018179974,-0.0067877728,0.06446531,0.11771293,0.021860316,-0.09766149,-0.08686996,0.028545672,0.038864598,-0.042685572,-0.029447965,0.0925869,-0.08349925,0.036747865,-0.08111657,-1.1080678e-33,0.07221571,0.023702146,-0.004041783,-0.046260457,-0.013828599,0.00028405365,-0.10005868,-0.030314485,-0.016941188,-0.0895964,-0.020902641,-0.061562985,0.04592668,0.0079751555,0.02186767,-0.052694283,0.022930656,0.006280945,0.07082036,-0.03442046,0.0660771,0.087644584,0.02020851,0.0161003,0.029858526,0.035644583,0.00018246642,0.0085518155,0.0171669,-0.009519349,0.06692923,-0.14396018,-0.120919354,-0.039691,0.11750328,-0.029653298,-0.039595842,-0.026647218,-0.058875963,-0.013271065,-0.014998213,0.08576241,-0.04262697,-0.0005430042,0.08164617,-0.097814634,-0.019146668,0.12778056,0.03804244,0.095995225,0.036974143,0.007939489,0.083049364,0.038474068,-0.04116998,0.036399044,0.027556265,-0.053965088,-0.00847305,0.011186182,0.040926024,0.010440965,0.02082799,0.06538854,0.046411976,0.03793245,-0.016007641,0.01802192,0.030010344,0.077253066,-0.069183365,-0.025707766,0.0067962515,0.036488034,-0.01983969,-0.043266468,-0.076841384,-0.04213432,0.04652448,0.026283251,0.0060373056,-0.006811551,-0.009545651,-0.012807958,-0.05468921,0.0003342633,0.019376086,-0.032690775,0.045641273,0.022453371,0.04329553,-0.06376223,-0.06421616,-0.03942409,0.039154857,-1.9858104e-33,0.07815105,-0.059691034,0.051840942,-0.009352942,-0.06579063,0.06569407,0.032790277,-0.02288018,-0.007799539,-0.04685128,0.007892169,0.02209622,0.060564343,-0.0808457,0.022954583,0.008036061,-0.02835594,0.10692659,0.04568343,0.0179909,0.030221751,0.08877991,0.027359905,0.06502178,0.030167738,-0.02132492,-0.10563697,0.033775873,-0.0035612714,0.07334496,0.044171188,0.060656797,-0.03988262,-0.12110972,-0.053041212,0.047334865,-0.049371947,0.04982944,0.021266593,-0.011210796,0.042769484,0.03727308,0.035915688,0.06503954,-0.03696091,0.044113472,-0.075400025,0.079224855,-0.008044377,-0.0077869464,0.00190453,-0.031194553,-0.03465959,-0.03884394,0.031167759,-0.0055654696,0.0113630425,0.005036921,-0.044175506,0.03262633,-0.0041426034,-0.09560489,0.03021419,-0.03862185,0.045398466,-0.000972376,0.054197777,0.101428136,0.002807464,0.0042642294,0.0680042,0.08294553,0.034225646,0.03330475,-0.024899583,-0.022289578,-0.13809139,-0.001126375,-0.013298302,0.018262776,0.007617334,0.049903058,-0.0135503905,-0.05837108,-0.012084225,-0.12828557,0.054405488,0.0067195687,-0.032950692,-0.0012830304,-0.050534654,-0.07364891,-0.06669571,0.0093796225,0.035310317,-3.1876866e-08,0.0023389433,0.0073169996,0.08326491,-0.07323734,0.016879894,-0.009460414,0.020228246,-0.02772022,0.02616182,-0.07232656,-0.0072923466,0.07008771,0.046983592,0.0024020686,0.021787496,-0.021520441,-0.02207291,0.061089147,-0.045861233,-0.037552055,-0.08259741,-0.025481844,-0.12609501,0.05855395,0.025305443,-0.0077428636,0.042636845,0.04792268,0.042460974,-0.031606812,0.028136425,0.007822581,-0.018009873,-0.046938315,-0.13537346,0.00013641152,-0.05407257,-0.060567427,-0.07386042,0.06440958,-0.07594433,0.06803501,-0.0691001,0.030569158,-0.015671909,0.01844669,0.014462476,0.050128296,-0.06583356,-0.0043754424,0.061389916,-0.042787775,-0.010797185,-0.06990316,-0.10072542,0.074891575,0.017560437,-0.008144641,-0.024996262,-0.026513923,0.020552298,-0.022082357,0.17247352,-0.075038835 +1.14.13.189,"The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B. ",384,0.99999994,-0.058738362,-0.00366256,-0.18512686,0.006581956,0.0076628807,0.046851363,-0.027725363,0.012375312,0.07711548,-0.007762147,-0.023864428,0.0068038786,0.12865815,0.0140374005,-0.023469668,0.034299266,-0.07187257,-0.010616736,0.017910862,-0.031781893,0.0676338,0.09787942,0.026231365,-0.004688673,0.0961897,-0.024007455,0.030050589,0.007873465,-0.10358572,-0.033329017,0.04402653,-0.04888694,0.044301264,-0.04794055,0.1041017,0.0888334,-0.08116134,-0.025920823,0.13120651,0.041555777,0.0035380237,-0.017752638,0.0247024,0.015444091,-0.047494058,0.015271157,-0.02154819,0.05830291,0.034042653,0.015842043,-0.11715537,-0.031592265,-0.087089285,0.05339797,0.07324974,0.033816732,-0.021240357,-0.002145743,-0.059274416,-0.006996669,0.0821019,-0.034953672,0.04895016,-0.0077673784,-0.061354768,-0.09135172,0.0145408,-0.107225545,0.03431022,0.011006916,-0.06932486,-0.07101846,0.04427567,-0.01724023,0.001726711,-0.05176441,0.031436015,0.012029665,-0.024462538,-0.055324297,0.0686234,0.0008683221,0.044643935,0.112101674,0.030861303,0.0036561955,0.046256624,-0.002848261,0.077974804,0.07814223,0.044984113,-0.025930779,-0.05990593,-0.08658205,-0.08937105,-0.06269004,-0.072836414,0.007934133,0.0021561289,0.013515164,-0.014924426,0.0123807555,0.031656362,-0.049420368,-0.012561136,-0.009537935,-0.00042888627,0.09150291,-0.05709443,-0.013679525,0.04227495,-0.009379774,0.0006711748,-0.04673636,-0.01817483,0.07879332,0.1452644,-0.07416896,-0.12093355,0.0063122683,0.002579176,0.009723415,0.04226196,-0.006139077,-0.04744242,0.01356093,-0.11623951,7.837133e-34,0.004613123,0.049597446,-0.020278102,-0.039618004,-0.0095430715,0.009654394,-0.057302967,0.010939672,-0.017556557,-0.04517234,-0.063712895,-0.083337665,0.030992819,0.018312056,-0.009878632,0.014910655,-0.045272674,0.011004453,0.027346171,-0.026097378,-0.010268271,-0.009731677,-0.060660694,-0.01823898,-0.024887552,0.047252446,0.0044054845,0.032391265,0.045015626,-0.028574696,0.017597841,-0.014861949,-0.06583931,-0.02203653,0.07175336,-0.0015846252,-0.07367982,-0.01058175,0.08997488,0.05670733,-0.026996588,0.004174192,0.007236377,-0.01896472,0.023972187,-0.009818972,-0.067409694,0.083086625,0.09655355,0.04124273,0.03917038,-0.07576111,0.14040956,0.023029082,-0.078786045,0.008593684,-0.016660117,0.025094021,0.003995893,0.06442704,-0.037328683,-0.05994301,0.01621128,-0.01212168,0.040603064,-0.027358776,-0.013307247,-0.010718436,0.018721515,0.037607893,-0.039937142,0.007647337,0.06690074,0.02281596,-0.035366658,0.009427458,-0.07324892,0.00035676244,0.06774354,0.075093575,-0.0011834282,-0.0028347995,-0.03712761,-0.033793733,-0.08301333,0.053465072,-0.017416459,-0.1055608,0.018368645,0.06594425,-0.045853883,-0.11044492,-0.074746594,0.019084971,0.037329577,-2.8541513e-33,0.0944556,-0.07339529,0.09665479,-0.050579585,-0.069474034,0.045017216,0.004488074,-0.03243325,-0.047937255,0.009016259,0.09725892,0.01577204,-0.019249527,-0.066653594,0.042481367,-0.04267061,0.044062745,0.07161974,0.042947054,0.049638465,0.061980337,0.07799136,-0.011548263,0.00229927,-0.00019440378,0.016803779,0.03174915,0.038248274,0.067476295,0.105023876,-0.00087446027,-0.09040837,-0.054806408,-0.05698813,-0.05867395,0.08893304,-0.04337098,0.05202322,0.015694609,-0.031679694,0.082178295,0.0138147725,0.0163807,0.07483635,0.034656785,0.038675394,-0.091149345,0.062203806,-0.013106963,-0.0984839,-0.0052829063,-0.016904151,0.007959123,-0.0199638,-0.030075755,0.027515197,-0.004916621,-0.047591854,0.0018340652,-0.018631175,-0.048217423,0.016273499,0.020922981,-0.03224803,0.034471866,0.037630655,0.0170985,0.0043564187,0.09521081,-0.034257893,-0.020733029,0.0033591872,-0.022619806,0.043476757,-0.038029343,-0.02073116,-0.081658535,0.006624664,-0.0026165203,0.029281594,0.040324505,-0.011239121,-0.0026585732,-0.019128779,-0.027964776,-0.027554005,0.05134781,0.025937064,0.024905799,0.006433259,-0.054405548,0.080708094,-0.00043699687,0.04670034,-0.051246103,-3.30956e-08,0.055970423,-0.07545687,0.078080885,-0.044055488,-0.014933692,-0.017206572,-0.06189902,-0.053247124,0.03445602,0.038333382,-0.029773148,0.057242405,0.0025592896,-0.034739234,-0.033965886,0.022583505,-0.056830503,-0.0006889716,0.01630652,-0.025755921,-0.07559003,-0.035826113,-0.07952617,0.020164965,0.07844235,-0.03772328,-0.042464387,-0.011542551,-0.020972755,0.00039030006,0.06158977,-0.0056976173,0.010999438,0.03255624,-0.039271284,-0.033465993,-0.07961234,-0.087463126,0.03953172,0.010251217,0.055976786,0.02536422,-0.028515706,0.04360272,-0.07694433,0.009746765,-0.04786124,-0.05282483,-0.062382303,0.009428723,0.03300297,0.010289217,-0.02492042,0.009595547,-0.10443161,-0.008390658,0.04773948,-0.07162651,0.00067644677,0.00695315,-0.010069675,0.014699895,0.15194167,-0.056211334 +1.14.13.190,"The enzyme is found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.",384,1.0,-0.063344404,-0.041938562,-0.15170287,0.03695137,0.07074622,0.09690939,-0.1302365,0.006969332,0.065491855,-0.10235406,0.0478554,0.009321739,-0.09276203,-0.04323076,-0.041942094,0.07500373,-0.05794235,0.0053495266,-0.03594566,-0.010535825,0.03461878,-0.0047388677,0.035700917,0.019459078,0.07315986,-0.032554533,0.05604496,-0.031762365,-0.03514157,-0.019149922,0.076684125,-0.0013523787,0.08758602,-0.10205332,0.009824393,0.08431795,-0.042279404,-0.019538997,0.07542186,0.0071084695,0.009550657,-0.045303505,-0.04909697,-0.05563067,0.03417742,-0.038069136,-0.00845255,0.037291206,0.08081805,-0.01396573,-0.07018764,-0.052603047,-0.06243311,0.011526624,-0.04225681,-0.014677911,0.00046933594,-0.0104895765,-0.057532042,0.08667297,0.04426687,0.0049653025,-0.02993431,-0.028142858,-0.079971194,-0.025099022,-0.011172081,-0.05531939,0.03229989,-0.09153609,-0.010391911,-0.092188515,-0.0811861,0.02543991,-0.0423454,0.01521417,-0.0027681487,0.019806402,1.4138288e-05,-0.0634475,0.06125537,0.048233826,0.012522181,0.081886016,0.06414714,0.07930649,0.02495503,0.03595389,0.043496177,0.027584862,0.009295524,-0.028384965,-0.0127190985,-0.03214117,-0.060004395,0.0010052267,0.0058287685,0.026277294,0.002739054,-0.02971476,0.018314937,0.03243217,-0.05047652,-0.12639837,-0.07382457,0.09484446,-0.054242514,0.018749809,0.024351297,-0.061686777,-0.019399595,0.04085566,-0.010292943,-0.056174893,-0.020876737,0.009383663,0.055293374,-0.05229454,-0.09921095,0.019480774,0.016192352,-0.043332707,0.052489456,0.023779854,0.035995293,0.050750073,-0.09146371,4.5928225e-33,0.042955663,0.0053509604,-0.023060186,-0.006356433,-0.039019335,-0.027256645,-0.056693044,0.09681036,-0.047910865,-0.056024328,-0.056729972,-0.07651719,-0.021889986,-0.012568425,0.028581908,0.024178091,0.04751653,-0.054734427,0.070827484,-0.008812356,-0.04986903,0.0723689,-0.057495344,0.00061251305,-0.039941445,0.051609755,0.017797267,-0.022813462,0.025840584,-0.013829475,0.09705407,-0.09698512,-0.06603364,0.005422675,0.03924841,0.039840244,-0.05714464,-0.07275054,-0.04236993,0.048413754,-0.0028178024,0.08707258,0.01128998,0.020673009,0.019895649,-0.012781678,-0.053614244,0.030129962,0.14785638,0.033527326,-0.031233357,0.048195813,0.17537925,0.074734055,0.008057334,-0.02580794,-0.0024015962,0.056675337,0.0029309785,0.056006983,-0.023813443,-0.031527493,-0.031667303,-0.005393822,0.0070953146,0.04821353,-0.06522236,0.0341092,-0.03574202,0.055551533,0.021819348,0.022485098,-0.019750053,0.044862624,0.011899366,-0.035768688,0.006113956,-0.01660501,0.025009355,-0.024568314,-0.04077238,0.038581192,0.032974113,0.041866366,-0.07212081,0.0042709247,-0.06249675,0.010094831,-0.026260532,0.04127758,-0.009367077,-0.012255125,-0.054602314,0.03153719,0.001066873,-4.3299367e-33,0.06056556,-0.08251213,-0.004903332,-0.08967632,-0.04236171,0.10560562,-0.037309084,0.008072944,-0.045300465,0.051136818,0.028245414,-0.037124097,0.020901792,-0.033159725,0.0066650724,0.036774967,0.0073256134,0.097104356,-0.029286472,-0.035601538,-0.08165458,0.10145361,0.06265633,-0.0064797592,0.03346691,0.034699544,0.011478641,0.04558208,-0.003663861,0.03150224,0.033104558,-0.04169143,-0.07472958,-0.020795004,-0.031753644,0.09824037,-0.016040258,0.020758742,-0.022927796,0.0753593,0.0034364448,0.039723597,-0.016325448,0.0083292695,0.06429433,-0.0028045268,-0.12717879,0.05971192,-0.058167838,-0.01726856,0.056049068,-0.02449173,0.06158043,0.023629462,0.04573061,-0.005274578,0.047375236,-0.031235235,-0.004301629,-0.06744548,-0.017880041,0.009227012,-0.025971493,0.045903802,0.0058921915,0.05996948,0.0032533938,0.05731611,-0.016569689,-0.008377958,0.025041,0.028590074,0.034136493,0.11666323,-0.051010016,0.058780827,0.013377815,-0.065178975,0.006539376,-0.011881631,0.0068227258,-0.040127855,0.034939833,-0.05369894,-0.09369352,-0.040434226,0.018435791,0.01547994,0.021392947,0.024371227,0.009384423,0.052205082,-0.03648959,0.03551373,0.0921908,-3.7344563e-08,0.04140777,-0.08293378,0.041568883,-0.06734426,-0.028823508,-0.0369127,-0.00096284365,0.01894087,-0.03708784,0.03857487,-0.024962729,0.09059564,0.020053852,-0.031188725,-0.006054532,-0.012825605,0.08025904,0.07713765,-0.02375156,0.04768732,0.008474312,0.038587302,-0.09457954,-0.010562453,-0.013782992,-0.14374115,0.0029019874,0.03276464,0.03494437,0.0065936227,0.04090551,0.0066784928,0.057568144,-0.059660885,-0.047497254,0.03345174,-0.035908863,-0.073520854,-0.028459296,-0.0013962181,0.028118273,-0.078321464,-0.02705565,-0.0149874445,0.0150654055,-0.026287975,0.04175682,-0.015271064,0.017592907,0.019390069,0.0126375975,-0.03599604,0.015513387,-0.039053567,-0.11883098,-0.039010935,0.017186131,-0.05149858,0.049926743,-0.10282587,-0.048248656,0.084193155,0.18572867,0.021629352 +1.14.13.191,"A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Participates in the pathway for the biosynthesis of oryzalexins, a group of related phytoalexins produced by rice.",384,1.0,-0.090008445,0.016080901,-0.05747123,0.038045045,0.06393509,0.09648642,-0.037044,0.034648936,0.019827414,-0.04400165,0.11099957,-0.021752764,0.023265695,0.020104786,-0.03840886,0.050823778,-0.04956671,0.04140532,-0.09630101,-0.09823149,-0.001790365,0.10441235,0.0059706047,0.04352704,0.012069748,-0.0507649,0.025133261,0.052664556,0.015895551,-0.034415763,-0.07448502,-0.035319213,0.00972871,-0.018376408,0.019709565,0.07769893,0.010641066,-0.08407887,0.049798075,-0.08700766,0.05985913,-0.06106069,-0.077633046,0.018303975,-0.04204142,-0.045334447,-0.005727645,-0.04400931,0.043438673,-0.06573867,-0.023026478,0.0014341553,-0.037076797,0.056163467,-0.030057821,-0.021763684,0.033008773,0.012725413,-0.057001892,0.041052308,-0.03912493,0.040905643,-0.018660817,0.04322744,-0.044196006,0.012575049,-0.05499332,0.017745046,0.013418743,-0.097101636,0.024026632,-0.108483255,0.0077566635,0.07537427,-0.03369164,0.027865183,0.0026580624,0.041749213,-0.015993176,-0.05476748,0.04270862,0.032091722,0.059932757,0.15071802,-0.010835364,-0.029965186,-0.0712919,0.10529656,-0.010222995,-0.058683623,0.04082201,0.051930755,-0.00014154345,-0.0033750425,-0.030312588,0.05047532,0.0400731,-0.023997279,0.016717177,0.014468369,0.050138157,0.054113522,-0.06231607,-0.06644994,0.011111857,0.025039665,-0.019186638,-0.025950562,0.026587686,-0.047580093,0.0028773325,-0.06407716,-0.001602904,-0.00047722968,-0.06285012,0.022398336,0.014456748,0.016930047,-0.013771,-0.055611704,-0.01466084,-0.007709283,-0.027143227,0.037011623,-0.027638499,-0.012125365,-0.10590604,1.5280944e-33,0.08399873,0.050903987,0.031677276,-0.015237221,0.010247662,-0.037759215,-0.027380131,0.022320192,0.0007141691,-0.010772849,-0.103846684,-0.086905554,-0.049798943,-0.026792642,0.03784659,-0.032957148,-0.08851997,-0.011991788,0.046303563,0.0057503246,-0.07663924,0.02232521,-0.096523166,-0.017695714,0.007760546,0.07928467,0.010183655,-0.078576446,-0.014621032,-0.0141923465,-0.02088903,-0.05203551,-0.091892555,-0.071403496,-0.029129578,-0.029167458,0.0062605026,-0.010350682,-0.09932422,0.0444354,-0.022843502,0.055205997,-0.015520481,-0.075417064,0.07498122,0.011709588,-0.11229709,0.085430354,-0.01604656,0.038148828,0.017167542,-0.043808457,0.08665135,0.056115594,-0.04390065,-0.04662816,0.035711493,0.021200016,0.010836751,0.071764186,0.06850894,-0.0057557467,-0.020702982,0.087110005,0.030256582,0.034547232,-0.08078756,-0.0690021,-0.008238762,0.084356666,-0.059898935,-0.024960523,-0.011443935,-0.05878984,-0.011780244,-0.054293495,-0.04319081,0.027138611,0.029452782,0.03516475,0.054620437,-0.031447586,0.027065782,-0.016160665,-0.05472094,0.047837444,-0.0035972584,0.016109493,-0.024159031,-0.010578153,0.06095052,-0.013584917,0.024806382,0.0152012985,-0.03755961,-1.8112032e-33,0.077368274,-0.040374715,0.040698893,-0.080291264,-0.02819207,0.004254736,-0.046017803,0.07787326,0.044046126,0.06196722,0.080193706,-0.024947954,0.06019829,-0.020363417,-0.008582576,0.07618361,0.005587523,0.09351679,-0.02368684,0.07753988,-0.073162,0.038368214,0.014078379,0.0042528724,0.034635436,0.057070818,0.008814268,0.050401974,-0.0076222094,0.05095212,-0.00072822423,-0.019611225,-0.09230817,-0.050115515,0.014149142,0.040077787,0.03168401,-0.02956723,0.030630771,0.075366184,-0.05143844,0.08919827,0.051931143,0.04988756,-0.018229844,0.0800205,-0.07701143,0.01258568,-0.039299294,-0.060739085,0.014166934,0.014484738,0.0011026582,0.034976725,-0.07098973,0.00097452535,0.019846305,0.02742811,-0.05916536,-0.07360871,-0.0015164868,-0.00029711262,-0.04041801,0.05782445,-0.013109587,0.09413854,-0.050463814,0.032591846,0.030787565,-0.0073084165,0.0072197355,-0.012085051,0.041964784,0.07509922,-0.037952628,0.045772035,0.005587397,-0.04211029,0.03722938,0.0820688,-0.0033145242,0.010783334,-0.03429781,-0.05444859,-0.011247889,-0.051198725,-0.030632976,0.16297193,0.06566916,-0.0068764864,0.020038221,0.038432702,-0.03371805,0.10573031,0.067546636,-3.308669e-08,0.017232072,-0.139914,-0.033742666,-0.0004043253,-0.032839645,-0.0066821375,0.02241105,0.009550487,0.09740252,-0.0014030526,-0.033896573,0.03015874,-0.08389355,-0.0017021627,-0.002398923,0.043655053,0.07540002,0.08242116,0.037339527,-0.011153355,-0.0060919644,-0.024965515,-0.025875367,0.0066789063,0.013628698,-0.05864642,-0.042721417,-0.024347791,0.08023316,-0.015111821,0.010183589,0.015217773,-0.03474284,-0.02838681,0.0200839,0.09898652,-0.018680535,-0.090127535,0.025298696,-0.053947266,-0.04594096,-0.057053264,-0.046740398,-0.04598605,0.041753404,-0.043984603,0.0723929,0.046518385,0.007064485,-0.051256936,-0.019750012,-0.04967734,0.06954582,-0.11619251,-0.07559036,-0.006360612,0.05569198,-0.0019018918,-0.024647864,-0.07977038,-0.014901877,0.03769955,0.21240817,-0.005560193 +1.14.13.192,A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Oryzalexin E is a phytoalexin.,384,0.99999994,-0.079354405,0.0067695915,-0.062427066,0.039974492,0.056564867,0.097489126,-0.021312911,0.054634977,-0.0043871463,-0.044530902,0.10297946,-0.02150767,0.015133594,0.06811299,-0.04047426,0.040836684,-0.007981586,0.028777355,-0.08475605,-0.0631923,-0.012899724,0.09004279,0.03258301,0.05522166,0.017058406,-0.035923455,0.010375343,0.07834303,-0.0017534283,-0.053564817,-0.06732136,-0.0365562,0.005779859,-0.024885872,0.014376164,0.03695924,-0.022646513,-0.07404277,0.03982551,-0.07531067,0.05357332,-0.040047605,-0.06905118,0.016878363,-0.031845085,-0.07030564,-0.044881515,-0.027568726,0.084020145,-0.06232928,-0.01184306,-0.026137654,-0.036910366,0.056911364,-0.021547535,-0.03132968,0.01755269,0.0055959816,-0.056922354,0.0597685,-0.022083681,0.04799305,-0.0021640784,0.044886347,-0.038623236,0.055667393,-0.04046749,-0.013351851,0.034343984,-0.08633777,0.017098976,-0.117596924,0.003685656,0.07818441,-0.029007465,0.025245942,0.011464895,0.037859462,-0.021444669,-0.023676837,0.023931053,0.023193382,0.02397773,0.15641467,0.0027960048,-0.00990357,-0.05510405,0.11958767,-0.013831562,-0.06636289,0.045291126,0.07460192,-0.005461959,-0.005329146,-0.0069350516,0.03844723,0.017778132,-0.006649671,-0.007697031,0.015471367,0.048650037,0.058643688,-0.062456388,-0.07028919,-0.006879668,0.034620557,0.012498242,-0.029297942,0.03065885,-0.070049725,-0.012425498,-0.08908981,0.0042671463,-0.022612352,-0.051849484,0.016876765,0.011282829,0.038471475,-0.002735365,-0.019077297,0.00020836348,-0.019374061,-0.008339236,0.034170013,-0.016530087,-0.010415661,-0.08232052,2.2523006e-33,0.070021965,0.05314536,0.045441892,-0.008442893,0.020142348,-0.005369172,-0.04706979,0.057995997,-0.0077932924,-0.044332094,-0.11089642,-0.051807337,-0.035709318,-0.0087394845,0.039347466,-0.05175621,-0.077323094,-0.030017022,0.061720937,-0.008055811,-0.052397233,0.032796804,-0.08825427,-0.020277724,0.00801811,0.055940937,-0.016732644,-0.062464513,0.006289451,-0.007531769,-0.009822457,-0.081440374,-0.107019395,-0.050523963,-0.050781153,-0.030329319,-0.0016860393,-0.013169033,-0.08149982,0.03737315,-0.024327122,0.049534347,0.00865962,-0.05676951,0.06523942,0.0010750327,-0.1389451,0.08569933,0.0041152444,0.019078255,0.042634543,-0.052045077,0.054115575,0.026824296,-0.070997134,-0.023402946,0.032619264,0.06077353,0.02022261,0.05147408,0.098563805,0.02769243,-0.0007642879,0.04329797,0.03899611,0.038544398,-0.0924865,-0.08688693,-0.021012966,0.03866055,-0.03997277,-0.03454308,0.022681894,-0.04337763,-0.0073533515,-0.043010656,-0.04431006,0.038298845,0.03730262,0.04273536,0.02530661,-0.044966362,0.028808149,0.00868634,-0.07746042,0.04734133,0.005232427,0.046210732,-0.014632482,0.023535404,0.040736713,-0.009067277,0.008672501,0.0077748094,-0.03371841,-1.9501277e-33,0.090689056,-0.0476962,0.056392238,-0.057223253,-0.022941064,0.011771206,-0.025539504,0.08567637,0.06343096,0.063217886,0.102236114,-0.049381934,0.06897418,-0.048967533,-0.0070525487,0.10684099,-0.025732726,0.08172394,0.0009755355,0.06991512,-0.09111442,0.024617447,0.016344031,0.006269514,0.047763508,0.07065439,0.033538513,0.02054045,-0.01503822,0.04493471,-0.00914173,-0.010632735,-0.09109768,-0.049750373,-0.018302074,0.062156342,0.023343166,-0.07824222,0.008219101,0.06595196,-0.053986847,0.1117774,0.0505742,0.038111534,0.0059459032,0.071877465,-0.0719473,0.004220878,-0.040827796,-0.022149103,0.04188652,0.02578752,-0.01849968,0.004794663,-0.054826647,0.018504197,0.015549134,-0.0032020493,-0.06554953,-0.074693695,0.029862978,-0.002147835,-0.058996957,0.0756831,-0.025545739,0.09279819,-0.05058888,0.032948054,-0.0008169842,-0.04096037,0.034845307,-0.04195572,0.05052521,0.059487313,-0.021569341,0.0467884,0.012532225,-0.02947476,0.024373231,0.04728529,0.015004447,-0.016949486,-0.04712815,-0.023968665,-0.00725316,-0.044467576,-0.022551976,0.13885266,0.060895707,-0.011944404,0.025487991,0.03642905,-0.053227473,0.08838347,0.09721351,-2.9887946e-08,0.07848305,-0.12009619,0.008637954,-0.021372044,-0.013332676,-0.022844309,0.038321357,-0.0054929163,0.091147035,0.009247519,-0.032431286,0.02250188,-0.094857894,0.0013775128,-0.014535256,0.038607758,0.057603173,0.07682715,0.04127167,0.0010336104,-0.015549119,-0.016691893,-0.009915567,-0.01661596,-0.011930959,-0.053727236,-0.019866599,-0.015480457,0.08359065,-0.022579705,-0.014840008,0.020262973,-0.036838043,-0.051582128,0.0115647875,0.11075987,-0.003626291,-0.09351612,-0.025681667,-0.019650938,-0.05229998,-0.098863006,-0.022625048,-0.06486539,0.060058214,-0.05175676,0.07103399,0.04203443,0.0006786435,-0.07470509,0.013140103,-0.051379483,0.059281833,-0.12649116,-0.10124816,-0.015211296,0.033544924,-0.0074899103,-0.040944315,-0.09148069,-0.016158665,0.020827627,0.20042886,0.020146044 +1.14.13.193,A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Oryzalexin D is a phytoalexin.,384,1.0,-0.08681269,-0.010392285,-0.0602382,0.02654855,0.048498824,0.08637516,-0.03671867,0.05521617,-0.00013653228,-0.034908988,0.095305234,0.003524336,0.01091899,0.06279927,-0.044062227,0.0494925,-0.0047750887,0.050141476,-0.07804332,-0.045032125,-0.019772487,0.10974386,0.03967127,0.053933337,0.03029803,-0.02891088,0.028962726,0.076806225,0.008990266,-0.030593216,-0.08191754,-0.029531796,0.0009820884,-0.026208853,0.03432237,0.031447273,-0.014054551,-0.053294327,0.037163816,-0.061987553,0.056868214,-0.035500955,-0.056556337,0.021432253,-0.04967653,-0.05309705,-0.06604267,-0.019973405,0.07934582,-0.051801626,-0.011519533,-0.024610013,-0.03784864,0.069212504,-0.026092988,-0.026933793,0.0143992035,0.013490431,-0.057733078,0.05330794,-0.03446695,0.05846118,0.0017850361,0.04228546,-0.020225216,0.048015747,-0.07025066,0.008174319,0.038918298,-0.09523923,0.020966606,-0.10914402,0.010082508,0.067285635,-0.030073011,0.003999827,0.017317526,0.005672088,-0.00935957,-0.05805757,0.036369305,0.033554118,0.040763848,0.16557086,-0.008457181,-0.0066919792,-0.053637173,0.12343616,-0.019010073,-0.07285357,0.047973853,0.077407934,-0.015119785,-0.023491975,-0.02826619,0.03679306,0.03088423,0.0019832468,-0.008772533,0.007846269,0.051273294,0.05162205,-0.071083635,-0.083603375,-0.012132717,0.039054528,-0.0064870673,-0.037250623,0.030779071,-0.075543866,-0.0058136443,-0.059557196,0.015825998,0.0052962634,-0.059561078,0.0043063574,0.023177994,0.03213425,-0.011749155,-0.04101944,-0.007185952,-0.03218375,0.0014776927,0.034730103,-0.015131514,0.0016589937,-0.07548381,2.1858496e-33,0.076956496,0.039040644,0.0404072,-0.0028366013,0.002927551,-0.022009285,-0.043082364,0.045040995,-0.017138321,-0.02502162,-0.12207398,-0.07713847,-0.049724776,-0.0124572655,0.04223995,-0.04749562,-0.07015946,-0.025205202,0.066748686,-0.013557708,-0.036987122,0.053670485,-0.089367084,-0.0027095573,0.025448862,0.061436314,-0.010542051,-0.045713805,0.014756833,-0.0062629515,-0.02004614,-0.07841084,-0.09400113,-0.054019287,-0.06010135,-0.016538914,-0.018322732,-0.009563394,-0.09760664,0.036935527,-0.025780845,0.025838144,1.6848404e-05,-0.059087932,0.05678119,0.014695497,-0.1409103,0.097412705,-0.009213983,0.029075295,0.0317522,-0.046569422,0.04762204,0.020831883,-0.071974896,-0.040033147,0.02506051,0.041266575,0.020236004,0.06704454,0.092489496,0.017642433,-0.010952559,0.06643593,0.03883613,0.015698096,-0.090175174,-0.0837659,-0.019793773,0.040012017,-0.041966084,-0.03304998,0.015415191,-0.046354473,-0.0020311368,-0.05826274,-0.02054996,0.029005554,0.039999362,0.01710076,0.029992256,-0.046211746,0.018912982,0.0051433872,-0.07270499,0.04408738,0.0013913311,0.02768338,-0.035204213,0.01703431,0.019575322,-0.010049971,0.0048571606,0.01244567,-0.028816393,-1.9672322e-33,0.0683412,-0.04462464,0.06006012,-0.06070274,-0.03124064,0.020455582,-0.024404772,0.09894603,0.064667106,0.04427571,0.09856046,-0.04419871,0.03439904,-0.038937148,-0.021464678,0.116628334,-0.02657293,0.0667955,-0.016908102,0.07309295,-0.09933464,0.031602297,0.007274634,0.013560957,0.053829968,0.073688224,0.030444156,0.027605122,-0.010931975,0.074400485,0.012065542,0.009056951,-0.08582678,-0.04400746,-0.020274235,0.06858888,0.018543353,-0.07433148,-0.00787272,0.082927756,-0.08250505,0.099934086,0.054166183,0.046237502,0.0037715915,0.060341764,-0.07257736,-0.007195738,-0.036478885,-0.021708287,0.038219493,0.014836226,0.014782965,0.025409602,-0.045635603,0.024451321,0.020591294,0.017144918,-0.06787478,-0.07052754,0.02987928,-0.008705188,-0.060938794,0.06269472,-0.015405704,0.091911785,-0.047354426,0.042843368,-0.005509585,-0.043427795,0.029913146,-0.022194048,0.058074396,0.061150733,-0.031696714,0.023193588,0.014330266,-0.014943247,0.031404816,0.07213985,0.008762124,-0.0005617473,-0.050808895,-0.009954548,-0.012923197,-0.041783728,-0.006073371,0.14098333,0.054046094,-0.0047477097,0.010452107,0.040606406,-0.052208357,0.08500468,0.09748687,-3.036468e-08,0.07473312,-0.12832431,-0.008848676,-0.034653608,-0.0072741047,-0.012404844,0.014964774,0.008201638,0.08317979,0.015299337,-0.042752557,0.03523296,-0.097171016,-0.0046182657,-0.011327438,0.042654958,0.04847875,0.06822847,0.028312728,0.0036287964,-0.009831184,-0.007795706,-0.027840784,-0.010825061,-0.018252434,-0.053392638,-0.020913305,-0.030973626,0.08526084,-0.0076618628,-0.00611417,0.016415302,-0.04193975,-0.05994065,0.029524677,0.12619527,-0.014373293,-0.095663846,-0.003729765,-0.020692592,-0.048666235,-0.0894099,-0.023092357,-0.049822547,0.050234172,-0.07402848,0.05843498,0.04403372,0.0003343573,-0.05005539,0.007136555,-0.050260928,0.054978963,-0.1363784,-0.08984303,-0.00061086164,0.034685902,-0.005569455,-0.06178011,-0.09608609,-0.020563096,0.018661939,0.1931513,0.024938347 +1.14.13.194,"A heme-thiolate protein (cytochrome P-450). Isolated from human tissue. The enzyme will also act on menaquinone-4. Prolonged action of CYP4F2, but not CYP4F11, on the omega hydroxyl group oxidizes it to the corresponding carboxylic acid. CYP4F2 also oxidizes leukotriene B4; see EC 1.14.13.30, leukotriene-B4 20-monooxygenase [1].",384,1.0,-0.04163094,0.032920357,-0.04269597,-0.027692793,0.05480441,0.08395362,-0.06043664,0.07369744,0.0006827446,-0.033938393,-0.024907662,0.0153888725,-0.02768848,0.06968343,-0.03696652,0.051777966,-0.029546358,0.05364569,-0.023556937,-0.07776885,-0.038275823,0.014700262,-0.013811032,-0.020914765,-0.021190623,-0.015632775,0.040250402,0.038663074,-0.031719524,0.008076053,-0.018691674,-0.015973443,0.014228116,-0.013705663,-0.0097355405,0.091221906,-0.049215224,-0.07144092,-0.0312338,0.004609298,0.037731472,-0.024369612,-0.10083552,0.0424122,0.027391866,0.00061598787,0.029018618,-0.036226027,0.011866129,0.014774201,0.010036977,0.04082206,-0.050288856,0.03397943,-0.020521143,-0.034396123,-0.060003653,0.00050601625,0.0007737694,0.020935297,-0.03296928,0.0071884594,0.02638056,0.06207846,0.048949383,0.022845844,-0.036827482,-0.011722808,-0.036700647,-0.09488729,-0.018162822,-0.06914729,-0.050756518,-0.017069556,-0.066713214,0.0617807,-0.06662038,-0.07337789,-0.0066944556,-0.03498512,0.04896932,0.013654627,0.015640456,0.118167065,0.061656576,-0.015068031,-0.015560703,-0.00907007,-0.09908713,0.030433709,-0.0057132496,0.06377298,0.013740002,-0.0066077565,-0.04974049,0.02868623,0.040500328,0.02656446,-0.016336014,-0.0009946225,0.0038926487,0.04798272,-0.0546303,-0.11304991,-0.057407964,0.018282536,0.0091865035,0.04770293,0.036279593,-0.006652397,-0.018044205,0.0070371414,-0.05546537,-0.02731008,0.049785707,0.068460196,0.027740438,-0.03804753,-0.07712169,0.0018734161,-0.032437928,-0.04309868,0.04916064,0.01039486,-0.0038977969,0.049375117,-0.04268625,3.8603157e-33,0.06919745,0.027499951,0.08147841,0.055059966,-0.004678411,0.008747132,-0.04190187,0.044465773,0.004181036,0.0014723737,-0.009732301,-0.002340439,0.016601589,-0.03591216,-0.06805036,-0.02704077,-0.004520252,-0.015865104,0.11264527,-0.0106386645,-0.00996059,0.035797697,-0.03012778,-0.01627861,-0.01004438,0.08101911,-0.013759987,-0.016430805,0.042917494,0.022596156,-0.09197835,-0.057163306,-0.109351456,-0.06794589,-0.013667834,-0.04069124,-0.051699195,0.006058062,-0.083590984,0.06331454,-0.023526244,-0.03247252,-0.00492192,-0.13225912,0.10868158,-0.06751405,-0.10003794,0.06428938,-0.018052157,0.026594546,0.04432534,-0.041564696,0.08718943,0.0037940214,-0.0684866,0.00039760812,-0.026175497,-0.018336,-0.012424174,0.100624114,0.13149779,0.072425075,-0.07942309,0.05057178,0.06395329,0.008275616,-0.0438819,-0.10110598,-0.12773502,0.10985994,0.015049826,-0.008639261,0.14147106,-0.01190971,0.048833456,0.010460941,-0.028725842,0.11612073,0.061941914,0.010663879,0.00081184186,-0.020208089,0.014054943,-0.024534727,0.008156101,-0.028605996,0.062547445,-0.039501023,0.020905731,0.016644076,0.06705297,-0.13309357,-0.029774673,0.011178344,0.025049243,-5.024466e-33,0.06944952,-0.03169381,-0.0045522368,-0.089619696,0.022156406,0.09236861,0.054585576,0.02607414,0.024034921,0.08682053,0.13595553,-0.06861086,0.048741926,-0.013141139,0.026504058,-0.013196674,-0.038717784,0.036904965,-0.053372514,0.0366394,-0.0039383667,-0.0026691414,0.057268348,0.06704661,0.09176103,0.030346084,0.015964964,0.0024633757,0.03923635,0.06193332,-0.067108184,0.07299052,-0.09070483,-0.0583864,-0.00635932,-0.0017813484,-0.057040475,0.04236378,0.024933236,0.034240875,-0.06285995,0.050292645,0.026841892,0.0965543,0.06004377,0.07461749,-0.0974185,-0.0027188465,0.01041652,-0.011543079,0.029419396,0.06022288,-0.09026464,0.004603317,0.026031861,0.07296578,0.0079457695,-0.012225961,4.7744848e-06,-0.04367197,-0.05046752,-0.061548274,-0.013099531,0.0802261,-0.015700167,0.029274708,-0.07271518,0.015149211,-0.0032986063,0.014619285,0.056832865,-0.043481976,0.053505734,0.030681511,0.01571336,0.028004274,0.020203236,-0.05221135,0.005557445,0.026748467,0.01326815,-0.006619006,-0.035329796,-0.06736188,-0.072908334,-0.1405875,-0.013608088,0.102514535,0.0100297555,-0.029584374,-0.024987897,0.05609711,-0.10488251,0.046004247,0.004205461,-4.177263e-08,-0.032987908,-0.012675682,0.093370825,-0.03254497,-0.031055404,-0.026963215,0.024969626,0.008093193,0.083292,-0.031075275,0.0012745984,0.07264992,0.013526607,-0.049879123,0.029580478,0.03873334,-0.0026795706,-0.036319178,0.025279827,-0.0066395197,-0.037418753,-0.00022256588,-0.020513974,0.027873928,-0.0045507615,-0.10995808,-0.0042670737,-0.0427411,0.038739897,-0.015264036,0.04060505,0.034471516,-0.033611342,-0.031313106,-0.022126826,0.014249338,-0.0077334377,-0.007080307,-0.029904887,0.0006979497,-0.08038017,-0.10844507,-0.08421291,-0.012654627,0.045973085,-0.0056519452,0.046585124,0.03998056,-0.026339114,-0.030316526,-0.05613086,-0.0129676685,-0.023424523,-0.09522225,-0.028999785,0.03823405,0.03321218,-0.07044859,-0.013378016,-0.16171226,-0.037020233,0.012458877,0.15022416,0.025056787 +1.14.14.15,The enzyme from the bacterium Streptomyces globisporus is involved in the biosynthesis of the (S)-3-chloro-5-hydroxy-beta-tyrosine moiety prior to incorporation into the chromoprotein antitumor antibiotic C-1027.,384,1.0,-0.084058955,0.039788675,-0.20006688,-0.03472723,-0.036426213,0.03813761,-0.01024902,0.05141316,0.07083211,-0.01490064,-0.026554404,0.015498416,0.010981343,0.031111378,-0.054546818,0.0040661567,-0.03730125,-0.003414307,0.045313664,-0.07269693,0.019629642,0.031403106,-0.027774982,0.017457923,0.050222676,0.023917409,0.013440883,-0.050497465,-0.07465287,-0.0032893533,0.015039906,0.028775347,0.1276786,-0.054926943,0.06862883,0.049567625,-0.068051204,-0.08008566,0.064017415,0.06502874,-0.022374148,0.009292754,-0.0153356185,0.13521345,-0.057523336,0.04458813,0.023445703,0.117168315,0.042618796,0.019487636,-0.05434119,-0.028110059,-0.11513678,0.028771894,-0.0008364468,0.041378032,-0.029668266,-0.009516789,0.024528436,-0.037436847,0.048181817,-0.039194092,0.1153751,0.026581066,-0.042575505,-0.04041647,0.017295182,-0.10618458,0.042240236,-0.055069778,-0.026546005,-0.02014625,0.014608757,0.01837209,-0.061072867,0.03437498,0.020495465,0.049939644,-0.0047209417,-0.033456657,0.10122216,-0.01646979,0.044323146,0.093051605,0.06392965,-0.020660048,-0.0016025999,-0.0064575877,0.076182336,0.046465356,0.084793665,-0.056744497,-0.045482725,-0.030301837,-0.08166469,0.019243147,-0.03720835,-0.053780016,-0.042080272,-0.057764396,-0.039404266,0.027825348,0.07451628,-0.0033042512,0.0023372148,0.02352309,-0.023396105,0.11548144,0.004841514,-0.042556692,-0.03611903,0.006700863,0.011306344,-0.040420327,0.019246295,0.03401249,0.11712944,-0.030349975,-0.036072634,0.018595148,0.0021156596,0.0021058898,-0.010422841,0.0005445838,-0.03096607,0.06826284,-0.08732753,2.0892166e-33,0.014640519,0.054513764,0.028858626,-0.0059723686,-0.02383196,-0.030885369,-0.07339406,-0.00038711072,0.0022692734,-0.048215188,-0.044263557,-0.08303878,0.041933663,0.02568594,0.014651647,0.026249092,-0.0052986923,0.051473066,0.062667355,-0.04636585,-0.018793281,0.04740297,-0.059406266,-0.03025793,0.024464019,0.118100114,-0.04428231,0.045416992,0.13622753,-0.0078836875,0.018302355,-0.039840367,-0.041673463,0.004033154,0.05451824,-0.007329857,-0.07634182,-0.07772448,0.041327044,0.03943712,-0.07482216,0.006511019,-0.016781038,-0.03854354,0.062154867,-0.040525973,-0.038572673,0.057446577,0.012378474,0.051305663,0.031652264,-0.04003316,0.048979014,0.06146023,-0.032185093,0.051887665,0.019925313,0.0208342,0.037059966,-0.01109063,-0.015645988,0.028871704,-0.035906088,-0.056088734,0.05000684,-0.06396206,-0.04572467,-0.024693256,-0.058973104,0.005529018,-0.026026083,0.015508779,0.042076852,0.048803978,-0.028233651,0.044341613,-0.020280976,-0.07948334,0.041201152,-0.0041240817,0.0012777097,0.0052318536,-0.00062413345,-0.03726326,-0.020371241,0.075263515,0.0145262135,-0.07730367,-0.035677344,0.056243565,0.010581564,-0.05934641,-0.067967765,0.033359323,0.008980396,-3.4822014e-33,0.0867922,-0.18640545,0.013177615,-0.070236765,-0.04460487,0.04303602,-0.06651107,-0.12306238,-0.0295154,-0.009959762,0.026721623,0.0019914496,-0.04324875,-0.056709465,0.015896354,-0.064436935,0.016834298,0.121612415,-0.067392305,0.010333407,0.07139736,0.015734974,0.05833023,0.020893108,-0.025877075,-0.0084627215,0.025539972,0.057969663,0.070592515,0.106505044,-0.023828141,-0.07294981,-0.038435243,0.008959163,0.0354425,0.05596064,-0.050131455,0.032699637,0.13338715,-0.026207006,0.046087116,0.0079690125,0.007577974,-0.0368508,0.057903886,0.07752433,-0.006107389,0.077720694,0.03401004,-0.034833748,-0.0017056318,0.0003217349,-0.024513712,0.048853222,0.0027789834,0.01637773,0.03525631,-0.013414247,0.01734773,-0.059526667,-0.034201834,-0.011456695,0.025304444,-0.004511235,0.074777715,0.08220542,-0.025946116,0.1296603,0.07840644,-0.06737982,0.002383163,-0.01911192,-0.05128908,0.06699365,-0.006783667,-0.056636706,-0.04145286,-0.025639586,0.024107704,-0.029878648,-0.037456032,-0.0038981969,0.049660657,0.009453224,-0.0480822,-0.06971125,0.017888805,0.03975126,0.052977603,0.058672912,-0.042984925,0.039213307,0.0066833566,0.030751247,0.045503635,-3.651174e-08,0.018174237,0.005275012,0.08315432,-0.06024414,0.011495493,-0.008843137,-0.10960475,-0.05096267,0.05253476,-0.017540492,-0.017762097,0.017729046,-0.0030639798,-0.028360516,-0.015548965,0.022317888,-0.07946412,-0.113225855,0.029839534,-0.019672614,-0.07269418,-0.010221856,-0.036096152,0.02360823,0.01635801,-0.07105612,0.022747245,-0.031799346,-0.0061616143,0.020702634,0.023235807,0.011576026,-0.059448358,-0.027935691,-0.032316368,-0.047724485,-0.028608698,-0.055172548,0.06579752,0.040845264,0.008920762,-0.0076460415,-0.059645005,0.041526034,-0.019913783,0.025131404,0.0007031722,-0.039702155,-0.11678724,-0.05256237,0.021771247,0.0160584,-0.078182474,0.034151305,-0.09180148,-0.0068637454,0.00018960267,-0.045951597,-0.009166845,-0.04444492,-0.057307873,0.003364734,0.14674814,-0.02674602 +1.14.16.7,"The enzyme, characterized from the bacterium Streptomyces coeruleorubidus, forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine), which is one of the building blocks in the biosynthesis of the uridyl peptide antibiotics pacidamycins. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.",384,1.0,-0.037471004,-0.08683655,-0.11804529,-0.05995723,0.045485586,-0.010704277,-0.06785676,0.074605525,0.096624054,-0.009120099,-0.005038628,-0.009789677,-0.0036570511,0.09111521,-0.051222313,0.00027154572,-0.12582445,0.0077550686,0.0369611,-0.044545975,0.07677075,0.026291786,-0.012231622,0.033411957,0.06993881,-0.019883962,0.059708595,-0.032556444,-0.06778096,-0.06745342,0.06731634,-0.019552581,-0.017097097,-0.06931257,0.06876544,0.087107554,-0.037722126,-0.019856973,0.13963819,0.05588801,-0.0038502915,-0.048064597,-0.015410427,-0.006357995,-0.04415027,0.0251927,0.012142133,0.13283211,0.005114782,0.058744647,-0.015439149,0.0063120653,-0.0024934274,0.048746806,0.04134248,-0.005697894,-0.03143654,-0.010011963,-0.001943612,0.0048195245,0.1019341,0.02717407,0.05997187,-0.017675512,-0.06680841,-0.051927384,-0.019459512,-0.06693972,0.08741496,-0.09665381,-0.089216195,-0.032017928,0.052991856,0.06303077,-0.031417746,0.025128145,0.008158308,0.0088378675,-0.027811782,-0.0023295972,0.047763083,-0.025623754,0.0061785458,0.09514658,0.102752715,-0.085928455,0.053413443,0.0034813469,0.07202928,-0.026130734,0.09833808,0.022547979,-0.0023997475,-0.035489783,-0.04093099,-0.017147051,-0.033908878,0.013972817,0.0033278037,-0.014041625,-0.06553874,-0.0051621776,-0.019173456,-0.015185514,0.021252384,-0.053637713,0.053681042,0.14337644,0.006703348,-0.045082822,-0.001976517,-0.024614293,0.0546407,0.06358865,-9.162125e-05,0.05367171,0.017162574,-0.081861846,-0.10451569,-0.029422374,-0.018785909,0.016502397,0.07180651,0.0056104627,-0.0036170706,0.07489087,-0.10493509,6.083818e-33,0.04275732,0.041689705,0.03573113,-0.021704668,0.040670827,-0.01947339,-0.06919995,0.026143802,0.03739284,-0.029752139,-0.0645456,-0.10265517,0.033976275,0.016204644,-0.017185347,-0.0578509,-0.034414165,0.009264395,0.023560446,-0.012551606,0.0251279,0.0945606,-0.044244375,0.03047007,0.07263598,0.045218956,0.0056204,-0.0068652947,0.11208618,-0.027528709,-0.06682725,-0.10800259,-0.0646644,0.00837149,0.072698034,-0.026298106,-0.06625452,0.0025161502,0.019233467,0.06882512,-0.016965304,0.018803658,0.052491866,-0.0785129,0.058739394,0.00836094,0.008757404,0.067507096,0.001986807,0.03689594,0.06385926,0.008398914,0.08113586,-0.022087794,-0.05656527,-0.049191844,-0.04225751,0.0004233346,0.051919263,0.033524577,0.01959609,0.03612853,-0.027594224,-0.013601203,0.0013576376,-0.049398966,-0.022035208,-0.020412026,0.01765627,0.022293137,-0.07118963,0.017443746,0.06256041,-0.020026619,0.064828604,-0.027341517,-0.07042687,-0.020716302,0.062367644,-0.061339404,-0.018182453,0.049456384,0.015331512,-0.0020865102,-0.0067286873,0.03370683,-0.0064337165,-0.0607694,-0.0037331264,0.031330597,-0.028723504,-0.08415417,-0.098024055,-0.017661186,0.06594092,-5.4202603e-33,0.10624612,-0.09660957,0.059775274,-0.045844544,0.01367759,0.10792117,0.01031734,0.040627778,0.061763465,-0.08169292,0.08649464,0.005661107,-0.067237064,-0.054046847,0.023715641,-0.0151405,0.00889863,0.04373196,-0.014430366,-0.017921194,0.03830986,0.027464276,-0.019291474,-0.012077971,0.04475182,0.041239753,0.037818648,0.050214995,0.12538467,0.0425229,-0.024621919,0.017966283,-0.032340936,-0.001840835,-0.02837425,0.09397707,-0.1374046,-0.000931993,-0.015255401,-0.008284132,0.017773064,-0.05575965,-0.018569719,0.048899908,0.032170333,0.0072906567,-0.069532566,0.009250511,0.010868296,-0.03415921,0.06121409,-0.08114957,-0.007846031,0.00044272613,0.010760798,-0.006235739,0.081606574,0.021319898,-0.03687776,0.013891988,-0.034087583,-0.06327437,0.025731856,-0.015817536,-0.019322434,-0.026955057,-0.03434125,0.10674699,0.10522971,-0.022356726,0.057667784,-0.02802234,0.0009843794,0.04234748,0.056526855,-0.03571058,-0.08189492,-0.04664947,0.05467844,-0.02278948,-0.044314675,-0.014564842,0.0039413422,-0.044719525,-0.0037285057,-0.01986388,0.059915926,0.02325887,-0.017996052,0.09372946,0.025130916,-0.024116756,-0.0034183492,0.070300564,0.024072364,-4.9957663e-08,0.08620645,-0.04670161,0.059393737,0.0007491472,0.03099933,0.016420662,0.0028534592,0.005442449,0.0022417055,-0.095346145,0.03533328,0.019640815,0.005906635,0.024327796,-0.011710093,0.0133755775,-0.07938374,-0.04997254,-0.012314332,-0.0140422,-0.082952864,-0.054126285,-0.13067372,0.02360032,0.068917215,-0.014072546,-0.05030057,-0.010221668,-0.034587737,0.0018284161,0.060915936,0.0070677567,-0.054962818,-0.03449468,-0.022471432,0.020395136,-0.100583225,-0.04351346,0.02215498,0.0063929916,0.0077578407,-0.01177668,-0.07895619,0.020589279,-0.012163504,-0.01680834,-0.06411376,-0.0001222289,-0.05031813,0.0038547725,0.032661024,0.032369636,0.006052486,-0.045047235,-0.10079871,0.038146816,-0.010664826,-0.08036062,-0.06144268,-0.07230696,0.013128655,-0.014697368,0.1542041,0.013825377 +1.16.3.2,"Ferritins are intracellular iron-storage and detoxification proteins found in all kingdoms of life. They are formed from two subunits that co-assemble in various ratios to form a spherical protein shell. Thousands of mineralized iron atoms are stored within the core of the structure. The product of dioxygen reduction by the bacterial non-heme ferritin is hydrogen peroxide, which is consumed in a subsequent reaction.",384,1.0,-0.019918278,-0.033577908,-0.11522777,0.09342773,0.121344574,-0.02300664,0.038044322,0.044250093,0.083850846,-0.048723474,-0.016181866,-0.0042682504,-0.03721427,-0.011632589,-0.13279852,-0.082504675,-0.071032,-0.011014479,-0.010141033,0.04138731,0.010933685,0.025303105,-0.00032437217,-0.018422633,-0.030634154,0.057350025,0.00094867265,0.043529097,-0.03294594,-0.06692257,0.05179166,0.002539527,0.059990402,-0.030586917,-0.016194219,0.1048309,-0.020171804,-0.04041618,0.04624028,-0.05034052,-0.050212342,-0.035433665,-0.053792894,-0.054865558,-0.032643132,-0.02173134,-0.0076873424,-0.08057741,0.04217463,0.040223114,-0.062204666,-0.030256085,-0.08213751,0.062773205,0.06825248,-0.008339803,0.019968498,-0.08441305,-0.024906147,0.009077039,0.05951483,-0.042407602,-0.019394794,-0.0143676745,-0.021939285,-0.012390289,0.070061274,-0.034364868,-0.053638175,-0.08106095,-0.009844774,0.058740065,0.010829331,0.0014584407,-0.0034747317,0.13065326,0.06737955,-0.028270071,-0.0059923055,0.04099515,0.0013638082,0.06584325,0.06332747,0.058278184,-0.04980346,-0.022169951,-0.0448201,-0.066436976,-0.07736163,0.030081628,-0.019719047,0.13713439,0.056897886,-0.035394806,-0.036994424,0.005726044,0.04557995,0.09896475,0.028495356,0.00953723,-0.07899126,0.014781305,0.07147005,-0.055662114,-0.008264879,-0.064044505,-0.03849057,0.1295349,0.06666379,-0.008658794,-0.0037084764,0.0092947185,-0.00759613,-0.021346314,0.032696456,0.05958493,0.052538123,-0.04007177,-0.033716403,0.05743396,0.051293075,0.048470173,0.040150743,-0.0023651521,-0.039999716,-0.03394866,-0.07349761,1.1856841e-33,0.05074618,0.04711261,-0.0023079582,0.07103372,-0.069547564,-0.022661924,-0.07343224,-0.07912615,0.100700915,0.03152696,-0.09638799,0.01840572,-0.013377286,-0.011896099,-0.006595499,-0.11701479,-0.022160755,-0.0567725,0.024843348,0.012499791,0.0655291,0.12152249,0.02199816,-0.0512034,0.06171646,0.021989202,-0.034526706,-0.024823595,-0.03850161,-0.020362966,0.03986724,-0.032497145,-0.07774589,-0.08619562,0.136406,-0.05479476,0.018117059,0.032653067,-0.05139918,-0.0010317739,0.06517764,0.014344189,-0.023570977,-0.013932526,0.12078896,-0.06947859,-0.06815577,0.09358981,0.0067536305,0.01571905,0.03326272,-0.01679163,0.063001245,-0.03935212,-0.08480415,-0.004049724,-0.007252587,-0.04285927,0.02335647,0.08424525,0.061935,0.032001,0.016184675,0.065345995,0.027999934,-0.030889675,-0.031180039,0.05922539,0.058984052,0.03212159,-0.026689654,0.024966849,0.11969546,-0.029431751,0.009484726,-0.07299674,-0.10693159,-0.004273374,0.04503792,-0.02190417,0.036566507,0.011100929,-0.04501327,-0.0426129,0.012535518,0.034371406,-0.061930805,-0.015130792,-0.017911637,-0.055707663,0.02616479,-0.033161588,-0.048836846,-0.06917591,-0.037542425,-2.7731818e-33,0.05092321,-0.08432544,-0.013389719,-0.012561988,-0.0046975804,0.102604255,-0.04555673,0.022678236,-0.05059282,0.022456663,0.004945368,0.0002733507,0.045168765,-0.09444473,-0.0067067556,0.007574654,-0.028260477,-0.018816527,-0.027105913,-0.064197004,-0.056692984,-0.011238247,0.020690588,0.015428312,0.057683244,0.018068219,-0.05197404,0.0060564703,0.046316613,0.05230565,-0.016021254,0.011544428,-0.00094301504,-0.08876399,-0.029496409,-0.061182067,-0.020246034,0.0059307003,0.037148986,-0.10668892,0.024337262,-0.05475354,-0.0046417946,0.061383158,0.02632533,0.034110144,-0.078340314,-0.0077385167,0.049280874,0.08578453,-0.014430101,-0.0023050432,-0.09566996,-0.04009869,-0.03749154,0.007027713,0.038280666,0.047395524,0.04889051,0.075089335,0.012208535,-0.051445358,0.12271374,0.090586334,0.023066288,0.066478774,-0.0015898293,0.07953086,0.054526806,-0.009461074,0.03757168,0.004956835,0.02101248,-0.047156975,0.05908987,-0.01594496,-0.015475057,0.014106303,-0.014516167,0.06223081,-0.031185871,-0.033750754,-0.02493353,-0.0070348466,0.014610354,-0.1286153,0.04042871,-0.006290523,-0.0736994,-0.055925287,0.0037230337,-0.036900584,-0.041677367,-0.013249835,0.00012647164,-3.7685552e-08,0.00916829,-0.00019400613,0.033705816,-0.0008240171,-0.019140583,0.007548368,-0.005611611,-0.0029881678,-0.0023989342,0.035016675,0.033646174,0.107859485,-0.054712005,-0.039909557,-0.024473315,0.047430526,-0.020890474,0.036536466,0.009319161,0.023619495,0.00016250683,0.017632747,-0.0075318557,0.055772252,0.04140335,-0.08206837,-0.06492319,-0.017703239,0.031520575,-0.010224554,0.00842272,0.047494493,0.0140096545,-0.041293282,-0.047937863,-0.026812045,0.0036047506,-0.020384377,-0.062080108,-0.0037403882,-0.031252883,-0.016222931,-0.07516772,-0.038702045,-0.0541266,0.033351902,-0.00950617,0.110200495,0.02462036,0.011514546,0.021236146,0.02559832,-0.008767509,-0.03349827,-0.09780327,0.11043828,0.080289744,0.0136577515,0.080818765,-0.033439882,-0.06380189,-0.06519439,0.11917741,-0.0027916143 +2.1.1.301,"The enzyme, isolated from the bacterium Streptomyces sp. OH-4156, can methylate a variety of linear oligopeptides, cyclic peptides such as nisin and haloduracin, and the epsilon-amino group of lysine [2]. Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. ",384,1.0,-0.02947086,-0.039043274,-0.14269708,-0.0530527,0.019325837,0.035827592,-0.046695374,0.062946804,0.07918737,-0.032213088,0.02499636,0.010380419,0.06458638,0.07294079,-0.021975394,0.01316395,-0.036293805,0.010019467,0.07135023,0.010485113,0.016635612,0.1331439,-0.019582493,-0.0041840225,0.012465186,-0.0056736027,-0.01952691,-0.0100159785,-0.02686282,-0.01682339,0.06495145,-0.024779255,0.00095866213,-0.01187677,0.105175704,0.06809226,-0.058642365,-0.032243427,0.11430454,-0.004145578,-0.005777055,0.027600406,0.009214017,0.0038247113,-0.03736282,0.048293613,0.03380007,0.009329528,0.0033471286,-0.027952038,-0.020323437,-0.10508264,0.010004806,0.031066291,0.012493848,0.013015186,-0.09361145,-0.05290274,0.018963708,-0.038082123,0.047481604,0.040254273,0.055105723,-0.010540892,-0.08939331,-0.027413204,-0.036951106,-0.057635695,0.055235613,-0.052148074,-0.04033747,-0.08497939,0.010198875,0.068203524,0.035878234,-0.01832703,0.01694609,-0.01683185,-0.06318792,-0.047904264,0.013257149,-0.013237944,0.021494426,0.09517198,0.05334285,-0.008507428,0.05490287,0.09009072,0.031385686,-0.011604155,0.09287792,0.042170666,0.03361375,-0.082858495,-0.053850096,-0.0716298,-0.04995073,-0.0025712615,0.033511583,0.06586681,0.026183428,0.012809444,-0.045720827,0.014383439,-0.026942221,0.023687838,0.06815459,0.08092531,-0.001768433,-0.07376143,-0.004604097,-0.011980753,-0.0014811279,-0.061089247,0.0028318285,0.05101173,0.1347783,-0.007675447,-0.037981745,-0.04743513,0.025681965,0.026641488,0.08669337,0.069168225,-0.033179026,0.087738045,-0.14017142,1.0923002e-33,0.03523979,0.06368899,0.062434226,-0.0748745,-0.006283018,-0.015555681,-0.04087388,-0.04329085,0.07884245,-0.04680502,-0.0899241,-0.07968858,0.034560017,0.04998448,0.022322584,-0.0062639974,-0.016795266,0.033907913,0.062135376,-0.04348691,0.014006958,0.022383519,0.008187049,0.027160801,0.046871528,0.055398054,0.03020554,-0.027443964,0.1205656,-0.030176265,-0.031779446,-0.038400352,-0.07103346,0.043972462,0.07116169,0.0056226794,-0.042384144,-0.04108635,0.12481637,0.04842804,-0.05587831,-0.011352537,0.038193222,-0.05624703,0.08857964,0.024172228,-0.06744721,0.051171787,-0.019304669,-0.038737882,0.05757494,-0.07114033,-0.016517283,-0.038810283,-0.10700537,0.044800583,0.0020346134,0.06499918,0.019269515,0.028208362,-0.0010813202,-0.023017732,-0.010873386,-0.02873576,0.021575125,-0.014801613,-0.033825718,-0.056730475,-0.0059809596,0.043088056,-0.07816306,-0.0036904004,0.08386741,0.014386098,0.07251593,-0.010405896,-0.100458,-0.034263782,0.06402616,0.047943313,-0.003330621,0.02579007,-0.07074814,-0.06764464,0.012042941,0.0018334086,0.041141517,-0.09615849,0.020267857,0.047017295,-0.0512361,-0.06195751,-0.06435591,0.005721573,-0.053776488,-2.7773163e-33,0.036535952,-0.042309552,0.061370656,-0.005575307,-0.03435615,0.014093755,-0.05327358,-0.009990746,-0.021406485,-0.09223954,0.090690464,-0.02575412,-0.0368438,-0.016191494,0.036279753,-0.01107594,-0.03347729,0.05596905,-0.015257454,0.044536754,-0.030859474,-0.026428511,0.027867349,0.0001616922,0.08521266,0.03473697,-0.005836609,0.0948997,0.13403979,0.044015914,-0.056995507,0.018767096,-0.016725035,-0.13204487,0.013111736,0.103391595,-0.10481105,-0.037525874,0.029825233,-0.06578126,0.008814298,-0.014656602,-0.0049356297,0.038620602,0.020520141,0.04381436,-0.020432899,0.034865465,0.008017684,-0.04900969,-0.0011339381,-0.010994813,0.040835217,-0.023646576,0.009144072,-0.041728854,0.029261287,0.0569979,0.002381195,-0.025363134,-0.02075105,-0.018987523,0.017169585,0.018572243,0.05580695,0.008622445,-0.011291437,0.019293226,0.043722197,-0.03007985,0.027154632,-0.039572187,0.04383488,0.033830293,0.017075246,-0.011055782,-0.08737943,-0.067260355,-0.022429712,-0.029632626,-0.018320754,-0.0019105141,0.007903111,-0.00515833,-0.0057801944,-0.049702022,0.051872544,0.06690259,-0.003008227,-0.0071942545,-0.025382746,0.030591628,0.03389712,0.040834688,0.010802155,-4.0668723e-08,0.08278189,-0.029372754,0.026732426,-0.06820734,-0.034064446,-0.019977858,-0.04606397,-0.116887994,-0.022267183,-0.030595906,0.01571565,0.05444498,-0.032295864,-0.0494639,-0.09147815,0.068312444,-0.10734207,-0.011619223,0.029842379,0.006820027,-0.0951008,0.054752927,-0.12122573,0.006437989,0.024322378,-0.036911603,-0.035033256,0.02917636,0.035663564,-0.017376756,0.068305306,0.036303952,0.02831186,-0.019608777,-0.04170912,-0.010649207,-0.12065689,-0.022155728,0.05462098,-0.029332502,0.021212412,0.0108905155,-0.09387368,-0.0031749788,-0.07197828,-0.011496184,-0.0074950336,0.013587288,-0.09212185,-0.020695694,0.02250813,0.014632433,-0.0014439039,-0.022222554,-0.08269448,0.016688537,-0.017113522,-0.07553999,-0.022838598,-0.072537854,-0.08543377,-0.06997503,0.18405074,-0.0023181385 +2.1.1.302,"The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B. 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This compound is part of the enediyne chromophore of the antitumor antibiotic neocarzinostatin. In vivo the enzyme catalyses the regiospecific methylation at the 7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1-naphthoate. In vitro it also recognizes other dihydroxynaphthoic acids and catalyses their regiospecific O-methylation. 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+2.1.1.305,The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin. 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+2.1.1.306,The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin. 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+2.1.1.307,The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin. ,384,1.0,-0.020878408,0.008024918,-0.13303144,-0.013765424,0.045722514,0.029211916,-0.061882794,0.04152414,0.114703394,-0.059569675,-0.047185823,-0.037480056,0.06689319,-0.05320912,-0.06619234,-0.0009794022,-0.04530513,0.007927343,0.0072767613,-0.021688513,0.14337166,0.03032532,0.0034766532,-0.036061507,0.044490013,-0.037143763,0.03514258,-0.06530316,-0.081359364,-0.07024885,0.08992186,-0.013580335,0.053624302,-0.080363,0.089957386,0.12314397,-0.036675498,-0.059915718,0.12330655,0.035261765,0.0031961545,-0.021822043,0.0032430592,-0.014095692,-0.09157977,0.052789744,-0.0057785874,-0.01389834,0.028178317,0.008097568,-0.015382776,-0.07505303,-0.068496086,0.025109613,0.09124012,0.03442227,0.004625528,-0.007431959,0.010931564,-0.04358368,0.09664278,-0.019142214,0.072835796,0.035253987,-0.12041235,-0.05014862,0.073162876,-0.06858792,0.013893047,-0.067300305,-0.07906489,0.09197393,-0.038416754,0.034644585,0.023492757,0.013397512,-0.005239616,0.016114743,-0.060196456,0.012764822,0.03617847,-0.01630696,0.024472326,0.061986107,0.06484225,0.0028959117,0.06915617,-0.0075823544,0.07103174,0.05956388,0.013729148,-0.03196761,-0.050450593,-0.0626023,-0.011137074,-0.067175016,-0.0835032,-0.04153126,-0.014598848,-0.010196788,-0.073969476,0.021447113,0.043344885,-0.011226691,-0.017037766,-0.0062940926,-0.0014867804,0.06670565,0.040289216,-0.046642605,0.0037946033,-0.052041207,0.07655236,-0.044522576,-0.028422378,0.089157656,0.098344445,-0.073749565,-0.055375896,-0.019728968,0.034092974,-0.009299057,0.006783735,0.027138928,-0.049515273,0.050930686,-0.10212354,1.5108723e-33,0.035003286,0.02993893,0.03824001,-0.037658643,0.0099962745,0.025624206,-0.042106077,-0.023906702,-0.01949785,-0.1339493,-0.061536316,-0.12161508,0.005178336,0.063781336,0.047368836,0.020470347,0.014157499,0.028069794,0.0075871754,-0.00782575,0.005013116,0.015254289,-0.041632324,0.040788304,0.004395863,0.026832389,0.018133702,-0.007626517,0.08844506,-0.03086458,0.0017941007,-0.042742517,-0.06307055,0.072718486,0.060829878,0.029860009,-0.02461968,-0.052697305,0.09079066,0.02179373,-0.06608819,0.01240725,0.035729118,-0.037195537,0.05393386,-0.023268988,-0.04933792,0.037013736,0.093022734,0.07598942,0.00819621,0.01349535,0.08738245,0.0028934102,-0.08376794,0.023602625,-0.06086271,0.013932396,0.0045126863,0.06437811,0.03352051,0.04269239,0.043856036,0.031903755,0.049846478,0.025447918,0.00039922356,-0.038087133,-0.014357703,-0.007131776,-0.054810558,-0.054363575,0.010853177,0.017410005,0.023926426,-0.006726315,-0.07975281,-0.06940651,0.03898883,0.013710404,0.016774695,0.0011719472,0.0018725074,-0.09815568,-0.06681218,0.017790444,-0.042647455,-0.020882329,0.01751457,0.107865185,-0.02585382,-0.10298348,-0.083215244,0.037300307,-0.015326751,-3.0137967e-33,0.08086182,-0.08154104,0.07953138,-0.03653316,-0.05648051,0.1021969,-0.023087649,-0.0039446354,-0.046481326,-0.02945337,0.06897423,-0.021847924,-0.018008841,-0.024269193,0.024191966,-0.052901257,0.017082645,0.106060244,-0.012430068,0.036112327,0.029670456,0.07413829,0.008334579,-0.032428384,0.05428063,0.035757747,-0.0069730794,0.06969724,-0.046249196,0.026047818,-0.05515269,-0.018592697,-0.058843013,0.043470174,-0.038718197,0.0832183,-0.05033584,0.0017654089,0.09296965,0.014426621,0.006149931,-0.022198621,0.032247275,0.01618632,0.015769808,-0.0048243394,-0.088684656,0.034969226,0.032043435,-0.07544052,-0.03721174,0.06319871,0.010103251,0.0034602776,-0.0114203105,0.00039352127,0.002810097,0.007263636,-0.045185734,-0.06415857,-0.039205667,0.024456471,0.038656455,0.025174834,0.022689572,0.06150589,0.026784863,0.024451412,0.068883106,-0.031884376,0.038357954,0.0015712484,-0.026202854,0.069458336,0.034681484,-0.036916357,-0.12769333,-0.022390164,-0.035350136,-0.007406991,-0.014256457,-0.041370038,0.065511726,-0.06470603,-0.0302843,-0.06382403,0.06375362,-0.0080969855,0.019570362,0.021467803,-0.039890345,0.029727662,-0.023535322,0.060480937,0.0768667,-2.7318736e-08,0.03385745,-0.022872306,0.05227218,-0.023815846,-0.001622659,-0.051771857,-0.015877727,-0.03525473,-0.052961685,-0.011504325,-0.057221353,0.03362713,0.01863874,-0.03057065,0.024487887,0.0012759756,-0.042753164,0.0036930353,0.026060103,0.0050052805,-0.07451293,-0.02588765,-0.08078418,0.05341214,0.03945121,-0.06336634,0.030113172,0.018282989,0.032329552,0.036236186,0.013349768,-0.003919729,-0.060591456,-0.069708526,-0.056236085,0.023616754,-0.077959836,-0.042883243,0.05204704,0.02454225,0.01639558,0.04627869,-0.03399617,0.001819652,-0.034730107,0.030271,-0.0006975511,-0.06304922,-0.094360046,-0.022093605,0.062158186,0.016827898,-0.0039021499,0.0479586,-0.0999945,0.0061777933,-0.01970856,-0.04771313,-0.06231909,0.003987417,-0.068502784,-0.012272836,0.22531171,-0.049853005 +2.3.1.233,"Isolated from the fungus Colletotrichum lagenarium [1], and the bacteria Streptomyces coelicolor [2,3] and Streptomyces peucetius [4]. It only uses malonyl-CoA, without invovement of acetyl-CoA.",384,1.0,-0.05238375,-0.06564818,-0.13823915,-0.02153109,0.022641556,0.02726354,-0.10960734,0.062478285,0.044298787,-0.09399181,0.03874104,-0.037222374,-0.07381162,-0.013084203,-0.10705669,-0.07436618,0.02302157,0.010290417,0.08380575,-0.017436413,0.052865177,0.10835174,0.010608214,-0.009919386,0.08251814,0.035235252,-0.020733878,0.027664933,0.030229544,-0.109714754,0.05810681,0.022717897,0.078653775,-0.057604637,0.07752939,0.05282831,-0.01379756,-0.0063599977,0.121476255,0.010498096,-0.030631429,-0.08425061,0.027248647,0.05383317,-0.12089618,-0.04991639,-0.042707164,0.0709047,0.03587326,-0.054556973,-0.005862489,-0.052133176,-0.07237626,0.086670056,-0.0031456845,0.036449417,-0.00388028,-0.021603055,0.0008380134,-0.013520438,0.010152289,0.050214496,0.017469136,0.01285584,-0.1169448,0.019021614,-0.0009359567,0.0015812748,0.056806993,0.008949648,-0.040937684,-0.011242913,0.0068060993,0.07876075,-0.029679598,0.076824605,-0.018067775,-0.061671257,-0.0040524118,0.0537023,-0.03475937,0.06958587,0.03938054,0.057336666,0.0017454348,-0.030794678,-0.015896168,0.031562056,0.0403894,-0.012820319,0.055788748,0.06644513,0.02609603,-0.040865663,-0.05554249,0.08866265,0.022372078,0.01067039,0.03292607,0.015329591,-0.03150566,0.012641677,0.03530212,-0.010456153,-0.028929738,-0.009979422,-0.017940097,0.0067778532,0.08750119,-0.041104887,0.0025404058,-0.023598634,-0.028799282,-0.09594232,0.04784275,-0.060219135,0.08873182,-0.05838925,0.010414069,-0.0030358946,-0.058743984,-0.009297745,0.055279206,-0.065538116,0.027391752,0.0522708,-0.020296913,3.4401816e-33,0.04083374,-0.007525123,0.013324568,-0.032608368,0.024950674,-0.026836261,-0.015253644,0.015887225,-0.06262918,-0.026735043,-0.030056182,-0.0392473,-0.04056528,0.022839593,0.028327696,0.04951101,0.015841532,-0.012870674,0.052919567,0.0095391385,0.045758057,0.06107331,0.0017918441,0.07066304,0.013446241,0.02388634,-0.0026216926,0.029029988,0.10356152,0.023198433,0.00760033,-0.031340938,-0.039709765,-0.009167694,0.015909852,0.014912587,-0.13067196,0.0060217776,0.009737986,0.079310626,0.07771189,0.044928737,0.043938104,-0.039189294,0.06174435,-0.030646777,-0.022348702,0.069399394,0.039824273,-0.010909338,0.010459005,0.018447625,0.02693296,0.039799124,-0.038060676,0.04788869,-0.0121053085,0.109236225,0.05342374,0.010896801,-0.019443695,0.12642322,0.028064748,0.0461336,0.06775344,0.01779093,-0.07486707,-0.026017185,-0.06648952,-0.015048138,-0.015022612,-0.0014685768,-0.061055038,-0.028726572,0.032527894,-0.046275057,0.008663545,0.010714242,-0.0041526337,-0.031059837,-0.046175767,-0.041545298,-0.0218367,-0.019707698,-0.10789316,0.057022624,-0.03991826,0.022631947,0.015602964,0.019945223,0.009960506,-0.078759365,-0.039369714,0.001915973,-0.019786427,-4.002854e-33,0.14015119,-0.103214435,0.071291156,-0.040187556,-0.079634264,0.10668097,-0.07373142,0.00044938977,-0.0441536,0.04024263,0.015425535,0.07098277,-0.019329298,-0.055878494,-0.025042584,0.032783903,0.07322477,0.028419891,-0.0465334,0.0343235,-0.004258266,0.071267776,0.023159053,-0.044830203,0.06280942,-0.04567805,0.011092261,0.01376211,-0.061597645,0.006645456,0.030170215,0.013819201,0.028511638,-0.096568204,-0.16096127,0.017616468,-0.07968663,-0.07539123,0.014700238,-0.014679086,0.008576225,0.024237014,-0.006589084,0.06481714,0.08812816,-0.051724415,-0.09714365,0.004059626,0.029517455,0.03612511,-0.03807093,0.0117036635,-0.033499703,-0.037477974,0.02240025,-0.03731634,-0.0011298987,0.025034724,-0.01508145,-0.03921428,-0.035360917,0.0030301923,-0.09421011,0.029817753,0.20370655,0.08988791,-0.06609756,0.06170266,0.025904836,-0.0039222767,0.040306605,0.015489595,0.019124666,0.02098678,0.07565121,0.047577567,-0.008875602,0.020090329,-0.05123741,0.02093688,-0.022077134,-0.08883593,0.028570045,-0.06542866,-0.058365554,-0.07318283,0.031514723,-0.0069330633,-0.05379037,0.06571969,-0.025230218,-0.0010286934,-0.019204592,0.01042792,0.07388702,-3.620594e-08,0.06578549,0.026732018,-0.0019943328,-0.019172575,0.0417392,-0.048628114,-0.014897109,-0.013001888,0.026938131,0.098331995,-0.09107934,0.0046900962,0.046079412,0.029550726,0.04222424,-0.0015282988,-0.011812825,-0.0048573655,-0.052761476,-0.023438495,-0.06456572,0.000107871114,0.023666324,0.051655255,-0.028410282,-0.047721837,0.085425526,-0.06637548,0.012446083,0.036206305,-0.04562617,0.060281146,-0.03652217,-0.06835063,-0.012580779,-0.00483683,-0.06354837,-0.065714374,-0.031281736,0.07550564,0.043494616,-0.0381321,-0.036380343,-0.01588186,-0.066430785,0.01089742,-0.022256514,0.012532696,-0.036715467,-0.0928812,0.017790345,0.0054650344,-0.05925142,-0.00784754,-0.07994903,0.006666909,0.052831996,-0.038912874,-0.025751239,-0.057785224,-0.05690072,-0.06692662,0.11030674,0.010884155 +2.4.1.325,Involved in the enterobacterial common antigen (ECA) biosynthesis in the bacterium Escherichia coli. The trisaccharide of the product (lipid III) is the repeat unit of ECA.,384,0.99999994,-0.07405063,-0.058782324,-0.13284348,-0.0596193,-0.05841431,0.054731756,-0.0549022,0.00033075182,0.09433802,-0.031835254,0.05538392,-0.15384984,-0.0605494,-0.013676113,0.045331314,-0.060422417,-0.00819233,0.019142967,-0.057524487,-0.09389531,0.0693316,0.046442673,-0.021607123,0.038638182,-0.14174591,0.023662215,0.08201551,-0.02254243,-0.024677701,-0.082094856,-0.009225829,-0.06884474,0.09423373,-0.08494074,0.06876215,0.052888066,0.046399634,-0.10396772,0.13375263,0.011009212,0.00911582,0.008776595,0.0037131517,-0.032717273,0.052312274,-0.018372582,0.0043892283,0.07992405,0.05511757,-0.054649316,0.025993016,-0.02812582,-0.043699715,0.06303522,0.014366149,0.029208956,-0.01642423,-0.08315782,0.031976275,0.01365708,0.036408897,-0.0045773736,0.12301578,0.08274508,-0.04697099,-0.11458361,0.07688018,-0.07996493,-0.031760134,-0.012525409,-0.116278075,-0.08071074,-0.03897087,0.07886529,0.029115327,0.037812114,0.0040337094,-0.040042244,-0.022283657,0.010634978,0.046890836,-0.02678957,-0.037116442,0.09483757,0.026736384,-0.087672055,-0.008149119,-0.03268927,0.01655427,0.054000817,0.027417013,-0.09335972,0.09571277,-0.010894939,-0.02785682,-0.0076798303,0.014258345,-0.040547613,0.078875974,-0.038379606,-0.05986608,0.016008815,0.006586638,-0.033774853,-0.025579568,-0.03174286,0.019185383,0.0853803,0.013297931,0.04556178,-0.039278805,-0.0596293,-0.01817067,-0.0058700377,-0.05195658,0.056284625,0.053540636,-0.10063919,0.049135692,0.014726312,0.018980175,-0.08133278,0.061320417,0.075641744,-0.009920709,0.009989224,-0.070882745,2.8521683e-34,0.020216973,-0.044724938,-0.023877632,0.01264036,-0.07584651,0.011783595,-0.032129813,-0.056254663,-0.039357312,-0.01746539,-0.0511082,-0.05988071,0.07383635,0.074533224,-0.040273007,0.08864919,-0.07959798,0.014145263,-0.013836056,0.0036402529,-0.04473254,0.0569108,0.038687684,-0.006736139,0.11741859,0.05942143,-0.069403395,-0.029256849,0.054711748,-0.004576532,0.03933982,-0.003952535,-0.05623722,0.006544299,0.09093031,0.0006478233,0.0671935,-0.008072716,-0.0045989812,0.028383246,-0.013556441,0.052413385,-0.0026086406,-0.029069103,-0.002015393,-0.030346893,-0.096013695,0.034627244,0.07326501,0.0055788024,0.05303525,-0.005646134,0.082986414,-0.0040729046,-0.025434343,-0.04522918,-0.023608966,0.028222634,0.018158738,0.067918666,-0.070709586,0.11963498,-0.03487008,0.04169631,-0.004286344,0.0145290885,-0.041615132,-0.019396666,0.01187396,0.0102067925,-0.022074565,-0.044729427,0.013166361,0.041058566,0.035012875,-0.071835615,-0.042867973,0.010259097,0.022760129,0.026776863,0.008031331,0.019241229,0.03994861,-0.034826275,-0.044095755,0.037656337,-0.053176325,-0.028559092,0.0069174077,0.028501555,0.05511408,0.03332509,-0.030771816,0.10042614,-0.0022777743,-3.427343e-33,0.04378431,-0.030567685,0.017072285,-0.0933468,-0.010102259,0.027910244,-0.045218248,-0.024633294,0.0404822,0.050666712,0.04597582,-0.014009325,0.040673554,-0.032253094,0.038201112,0.015656287,0.008916995,0.012718218,-0.044498365,-0.05278221,0.07223472,-0.09724444,0.056514233,-0.077991635,0.00575336,0.022638341,-0.060651716,0.052502584,-0.007608503,-0.017193383,-0.052100234,-0.045167938,-0.04926094,-0.011357532,-0.09345793,-0.022517255,-0.024124669,0.03766394,0.034820896,-0.07909526,0.0012533373,0.051972486,0.014261957,0.083319165,-0.00191213,0.05281088,0.03273636,0.065974616,-0.0005110727,0.036943123,-0.044231247,-0.050388765,0.04281402,0.017853089,0.022524782,0.057966024,0.036286414,0.004263104,0.027209323,-0.023989502,0.01201278,-0.02925423,0.07214581,-0.0413559,0.07866055,0.03253407,-0.06458993,0.021959791,0.054914832,0.015868898,0.078426495,0.041280992,-0.08290175,-0.055100538,0.009306966,-0.052621573,-0.13310097,-0.09628872,0.032465585,0.042877756,-0.012301083,0.022927005,0.021172239,-0.0063031497,0.017253406,-0.016967354,0.041582286,0.031224964,0.007411972,0.056235984,-0.032417163,-0.036771856,0.0043936935,0.038007528,0.013636686,-3.1418764e-08,0.021437054,-0.069541685,-0.021158986,-0.035328142,0.011294735,0.0027470763,-0.060169198,-0.007429117,0.07327332,-0.033712063,0.04860802,0.0735547,0.013963964,0.004404459,0.040169682,0.06548563,-0.056954656,0.002296207,0.0046053287,0.0019516407,0.005507356,-0.0074245897,-0.057164382,0.019559335,0.028914202,-0.04402097,0.00024176808,0.0062007457,-0.08771348,-0.052488063,-0.064274974,0.0016771291,-0.020299206,-0.023091126,-0.05108214,-0.029176507,0.00014618915,-0.034055058,-0.052328672,-0.03124185,-0.0063456534,0.015244008,-0.07294909,0.0039872588,0.035820413,0.07061227,-0.048661806,0.057819214,-0.06802612,-0.05408171,-0.02776005,-0.09139623,0.043123562,0.023649706,-0.0701357,-0.060341988,0.0061297626,-0.045899253,0.058312368,0.039333448,0.02389742,0.03951276,0.16736047,0.042622566 +2.4.1.326,"Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-beta-L-fucose. Involved in the biosynthesis of other aclacinomycins.",384,0.99999994,-0.06243343,-0.04388275,-0.15872794,-0.053056814,-0.038923573,0.012894054,-0.018989516,0.054339096,0.10043118,-0.036373787,0.101484746,-0.016222145,0.042430356,0.028678065,-0.014330113,-0.011245814,-0.057549346,-0.023626681,0.028920032,-0.052929793,0.04657318,0.10748338,0.0003247896,-0.03674097,0.07751645,-0.009112582,-0.0028649608,0.046884503,-0.01444159,-0.11570708,0.04879797,-0.034413226,-0.013254639,-0.01585931,0.10233561,0.09685221,-0.071454935,-0.0032818583,0.14948419,0.023898527,-0.03511692,-0.019142536,0.032071464,0.012931076,-0.011182311,0.00017286788,-0.06690389,0.02278212,0.05206713,0.0054113483,-0.011955276,-0.00981083,-0.0025247424,0.07174883,0.070023805,0.012666755,-0.0070003984,-0.0008164567,-0.033126436,0.0009932565,0.12805644,-0.008068705,0.017151477,-0.01628091,-0.10915255,-0.018528182,0.02092205,-0.06182826,0.077518746,-0.03730341,-0.055713374,-0.024986383,0.00025508646,0.058555454,0.026343113,-0.008779344,-0.009650202,-0.06663109,-0.014986387,0.02604477,0.07876158,0.05354107,0.02737836,0.08691163,0.008870833,-0.0405532,0.0811817,0.03157603,0.01598774,0.038174182,-0.003726387,0.030666158,-0.021283723,-0.075823225,0.012034229,0.0003288413,-0.026172575,0.0050677564,0.01570831,0.011554479,-0.03656929,0.019507792,0.03368272,-0.024139244,-0.028040143,0.013118115,-0.043637644,-0.007311868,0.03038535,-0.04190708,-0.030240903,-0.008137225,-0.016055835,-0.050662242,0.01816932,0.06378658,0.104146115,-0.091688976,-0.061970837,-0.08185248,-0.041389506,0.0007712612,0.035706002,0.03902717,0.017681219,0.024195435,-0.13161558,3.889597e-34,0.04352301,0.0639274,0.024894644,-0.024762712,0.08236214,-0.028174132,-0.08557832,-0.0620486,0.018436223,-0.014937485,-0.10595133,-0.06553202,-0.022641597,-0.0036132298,0.009114951,-0.02268843,0.025304876,0.059582718,0.040845,-0.033237603,0.021884376,0.07058795,-0.0071677268,-0.038375523,0.024721514,0.062075656,0.007547078,0.022060461,0.09259652,-0.012495419,-0.027891684,-0.07880786,-0.07309423,0.031168947,0.06072783,-0.009346788,-0.1439676,-0.050672002,0.07339086,0.025288636,0.033588782,0.029831633,0.050450277,0.008102352,0.050636884,-0.0062643103,-0.04586855,0.002216231,0.034787755,0.034588277,0.018027516,-0.01644644,0.052352626,-0.044135127,-0.07223486,-0.0068876916,-0.07750981,0.07986047,0.08032331,0.073248856,0.027267737,0.029084733,-0.042197146,0.010016814,0.046619132,0.005609917,-0.05520588,-0.011246537,-0.028815294,0.017950628,-0.025246622,-0.024121648,0.036997743,-0.062326368,0.0859881,0.024546005,-0.010215938,0.006427457,0.0035485704,0.0037808197,-0.09578005,-0.05030789,-0.025465762,-0.037171744,-0.060707584,0.017396977,-0.014526845,-0.019765016,0.014591847,0.054948274,-0.06218292,-0.029851109,-0.14399278,0.03987908,0.0614843,-2.2439667e-33,0.08446953,-0.07439625,0.08908205,-0.1118823,-0.02444473,0.09341013,-0.039642535,0.027016737,0.0009812617,0.026427401,0.046452913,-0.00081757107,-0.043677326,-0.11267814,0.01182063,0.0077101756,0.029161928,0.098278485,-0.052726995,0.09181105,0.015881969,0.098482795,-0.011385021,0.013262719,0.0076534385,0.040717702,-0.013563016,0.022908531,0.015669758,0.03887933,0.016921164,-6.310679e-05,-0.07015944,-0.08564695,-0.07909628,0.008407509,-0.0764051,-0.040643618,0.037211917,-0.008036235,0.07162993,0.051174436,-0.025621517,0.032736372,0.078889415,0.045533027,-0.026060738,0.016010534,0.01486032,-0.025312033,0.021815088,-0.0012598037,0.015393042,-0.02684392,0.016458115,0.014714396,0.026127595,0.028521018,-0.031908907,-0.00986327,-0.0061256145,-0.075967826,-0.03555958,0.014353915,0.044232804,0.038059272,-0.031556144,0.034756847,0.03907197,-0.015730007,0.025852894,0.029551776,-0.054083142,0.01295936,0.02193046,0.023228629,-0.100431375,-0.052956317,0.045618165,0.017563453,-0.006905865,0.003079759,-0.0006243076,-0.03182775,0.004030453,-0.049383268,0.020330107,0.0068791513,-0.0043487307,0.019091345,-0.032203577,0.069755465,-0.040648237,0.10391591,0.008027852,-3.587391e-08,0.07540745,0.024469638,0.072616294,-0.05478322,0.0033615285,-0.034662597,-0.07880152,-0.014936067,0.054089345,-0.010692728,-0.07990223,0.031304546,-0.0018661725,-0.060671512,-0.005370785,0.04707297,-0.05118121,0.0104947835,-0.001584844,-0.04274698,-0.05682363,-0.020299561,-0.049901348,0.07100587,-0.0062759575,0.0060128537,0.056887858,-0.025794603,0.011456497,0.008231697,0.06498742,0.041161515,-0.11318376,-0.02695209,-0.06438994,-0.020228585,-0.02519889,-0.07309038,-0.01731998,0.038871065,0.026955236,-0.0596018,-0.06616355,0.040416628,-0.10080854,0.06505345,0.002866399,-0.060584974,-0.07247348,-0.010070297,0.06892009,0.013558797,-0.026443094,-0.011402477,-0.12482003,0.03206437,0.018760752,-0.06357818,-0.027096793,-0.058771554,-0.049626254,-0.05536843,0.21583414,0.007751313 +2.4.1.327,"The enzyme, isolated from the bacterium Streptomyces galilaeus, is involved in the biosynthesis of other aclacinomycins. Also acts on idarubicin. It will slowly add a second 2-deoxy-L-fucose unit to aclacinomycin S in vitro.",384,1.0,-0.07065447,-0.027274404,-0.16886984,-0.027498059,-0.026523085,-0.009780544,-0.061025847,0.039429273,0.10150877,-0.009857366,0.0635204,-0.023238044,0.07366994,0.0376085,-0.034145482,0.010842217,-0.09356384,-0.004399957,-0.018937442,-0.069071464,0.07548353,0.059843272,0.009449409,0.0053621735,0.07972136,-0.06616291,-0.04145048,0.07323275,-0.05938493,-0.08391058,0.059662268,-0.042888273,0.028089963,-0.017818313,0.080287844,0.0823021,-0.06128179,0.003155733,0.17442243,0.019155908,-0.07724141,-0.035700493,-0.012273103,0.040713407,-0.019433826,-0.006755439,-0.022900496,0.018953795,0.03881504,0.039140522,-0.027828615,0.0025012444,-0.04416786,0.036412355,0.06872991,0.02446439,0.016457906,-0.041069746,-0.032114677,-0.005073385,0.05824127,-0.020941785,-0.008874555,0.051034205,-0.1354131,-0.053959727,0.0388912,-0.072417594,-0.0115069365,-0.042181548,-0.04385088,-0.07200031,0.045863196,0.003428082,0.04287276,-0.0120825805,-0.0018332179,-0.031177523,-0.06518512,0.0026611667,0.076670334,-0.020140074,0.041656308,0.0832587,0.039576907,-0.047517695,0.07537477,-0.021777425,0.049146593,0.06869658,0.02490088,-0.003495662,-0.028710127,-0.08182092,0.022341259,-0.011668198,-0.018083265,3.6594967e-05,0.0312938,-0.022819385,-0.03274902,0.0032627997,-0.012851451,-0.040316492,-0.00057963183,0.017659362,-0.016496079,0.05751172,0.028392904,-0.02827801,-0.0039795833,-0.03231266,-0.00040968982,-0.0427169,-0.012438359,0.1541716,0.13164386,-0.07307496,-0.10138418,-0.036947023,-0.042076956,0.015927717,0.02400889,0.049822483,-0.015962107,0.024296515,-0.112413265,2.1079328e-33,0.019112041,0.07000706,-0.05140906,-0.011373232,0.08218475,-0.0015727554,-0.074420586,-0.010246256,-0.0016588636,-0.040166125,-0.096294634,-0.04470422,0.017936451,0.014556563,-0.041119736,-0.029253801,0.033878766,-0.002411368,-0.01887475,-0.0018799611,0.030439336,0.018750858,-0.0046814485,-0.0129652405,0.027293118,0.101354405,-0.009612693,0.082124084,0.06424427,-0.022842148,-0.03866255,-0.071024455,-0.046637923,-0.006216333,0.10178832,0.012147915,-0.082248114,-0.026257427,0.072385,0.039361123,0.028452886,0.029743368,0.02085218,-0.020128593,0.04321304,0.0029254332,-0.07623559,0.07573232,0.06541191,0.050980184,0.054323573,-0.02837928,0.068434924,-0.04221532,-0.051364675,0.028852863,-0.079452716,0.023628026,0.06639997,0.040194787,0.022823064,0.004499899,-0.034945104,-0.0015630651,0.01744163,0.030047156,-0.00366266,-0.012553705,-0.035686668,0.016751133,-0.071557924,-0.016172076,0.009835214,-0.01365246,0.06291857,0.055538524,-0.03226759,-0.0044887676,0.055298373,-0.027537206,-0.043624576,-0.03660113,-0.044086378,-0.042348217,-0.040092375,-0.02356135,-0.04447977,-0.059800245,0.018625315,0.045610245,-0.023751827,-0.07290046,-0.050819684,0.019420039,0.07221139,-4.7375207e-33,0.06801495,-0.06472039,0.1065601,-0.09136575,-0.019962339,0.08073253,-0.040113997,0.00096531835,-0.016127322,0.017099781,0.023506412,0.0061508557,-0.039413545,-0.0708669,-0.041533872,0.00073021266,0.024929699,0.08033063,-0.045096613,0.083833955,0.022539902,0.095221825,0.013188922,-0.03292452,0.04565443,0.03804504,-0.026774906,0.044835486,0.06325187,0.035720162,-0.03613417,-0.02951214,-0.045053467,-0.07382392,-0.05607127,0.055307962,-0.052414726,-0.013711884,0.04515456,-0.039265133,0.07644359,0.016764313,-0.007992333,0.06311893,0.024314113,0.04143126,-0.06623341,-0.00066264335,0.002580652,-0.075519726,-0.004323711,0.025901644,0.008218052,0.0028957264,0.00619982,0.01426372,0.04291511,-0.01762082,-0.0029763712,-0.041659907,-0.019985395,-0.057797212,0.00157925,0.008574284,0.032307,0.05190099,-0.057365477,0.016507447,0.046658605,0.0008761948,0.032487817,0.00840981,-0.08137248,-0.007200138,-0.0258147,0.026845863,-0.10358245,-0.11252965,0.0077555478,0.03211406,-0.024619859,0.020890124,0.0060209013,-0.028979963,-0.044133004,-0.05031688,0.050699733,0.019952776,-0.027007317,0.0043664714,-0.01306189,0.053250883,0.018045096,0.049664557,0.013244313,-3.5634997e-08,0.008636441,0.019209146,0.11206731,-0.05367763,0.025204599,-0.022939095,-0.052052908,-0.014648736,0.043068163,-0.051632836,-0.07509313,0.12269973,0.034364436,-0.047880493,-0.040860504,0.044013616,-0.06829443,0.009486939,0.043135505,0.0006913363,-0.051125847,-0.0014221135,-0.08153246,0.047931623,0.0385744,-0.038646292,-0.014037696,0.0064750337,-0.008203331,-0.001312683,0.062888145,0.012213607,-0.045256563,-0.055288676,-0.105834074,-0.043739658,-0.050322477,-0.093183935,-0.009056459,-0.018772883,0.07242194,-0.016524965,-0.052547343,0.039516207,-0.07582005,0.046803728,0.016466513,-0.06291613,-0.07838706,0.028984535,0.09870183,0.0040412834,-0.016223004,-0.015106501,-0.09617927,-0.0017747565,0.019231593,-0.035942398,-0.00718339,-0.014198084,-0.07367761,-0.027567875,0.24142891,-0.040975776 +2.4.1.328,Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin. ,384,0.99999994,-0.021886557,0.03824334,-0.17848918,0.012274395,0.03338201,-0.0033834118,-0.017653944,0.046511713,0.09344952,-0.046576653,0.043720845,-0.03334036,0.028136572,0.038698826,-0.01786375,-0.0021167733,-0.019801693,-0.015820585,0.009601116,-0.039027132,0.041685816,0.03982608,0.063479334,0.006946784,0.050843343,-0.033229344,0.051486563,0.02720288,-0.04277728,-0.06382109,0.035375096,-0.07917667,0.061815914,-0.04361515,0.082160085,0.0814661,-0.07475147,-0.009754181,0.13702019,0.0070704184,-0.034345575,-0.026016222,-0.009352953,0.016055403,-0.048730794,0.06428782,-0.039785083,0.04377497,0.03947297,-0.03483124,-0.028980948,-0.012752886,-0.03092216,0.06465884,0.033779114,-0.018347692,-0.0056927414,0.003431223,-0.0005627688,0.006021077,0.097605616,0.0012508378,0.0129003525,-0.014604308,-0.15184937,-0.021954618,0.029729478,-0.0661228,0.062100112,-0.044207644,-0.089340664,-0.040741123,0.0064890166,0.12445843,-0.0073127183,-0.049265537,0.027771631,0.032432184,0.0309613,-0.0045337537,0.0966805,-0.009263798,-0.0027675105,0.13078542,0.022622082,0.039987188,0.058559857,0.041365888,0.0626271,0.0018620571,0.04859033,0.0016847652,-0.01951826,-0.03677066,-0.04739749,-0.03213936,-0.042131234,-0.0078316415,0.027646977,-0.008831596,-0.019608913,0.0084147155,0.052625585,-0.077699155,-0.07233538,-0.0012184109,-0.016965866,0.04634419,0.015952861,-0.051472295,0.0049431273,0.01753882,-0.0005644688,-0.036621854,-0.05751844,0.08024588,0.089137055,-0.051469035,-0.05560097,0.01756363,0.02321034,0.01901553,0.100543566,0.043419667,0.0007138165,0.0023796621,-0.1051988,2.1122194e-33,0.019507736,0.03496538,-0.06114444,-0.04372407,0.029222695,-0.01068792,0.00089540886,-0.013788561,-0.041833162,-0.04865753,-0.067781165,-0.122431956,-0.0069035036,0.03213512,-0.036216322,0.020178013,0.071526565,0.0055837003,0.04848571,-0.03323466,0.016182102,0.07545546,0.015039509,-0.05842455,0.0110013485,0.012231562,-0.03952793,0.019849483,0.109712146,-0.037522018,0.06227582,-0.10806719,-0.019316636,0.020525703,0.10245637,0.0069075106,-0.048773773,0.009759969,0.053528965,0.05445987,-0.0026656545,0.12147858,0.04333965,-0.00820314,0.05612399,0.02211302,-0.055721745,0.06069732,0.1097116,0.014076522,0.033327125,-0.03181962,0.05829728,-0.042519476,-0.07696967,0.004601231,0.018720418,0.055771474,0.062185183,0.027937416,-0.003888609,0.05052614,-0.026469855,-0.004837643,0.072397806,0.024322106,-0.067935,-0.035195526,-0.112334915,0.03284987,-0.06564983,-0.04357215,0.047361504,-0.015213034,-0.0110607445,-0.0039624157,-0.06485989,-0.042704087,0.024992825,-0.016190788,-0.07055095,0.0003487633,-0.032505445,-0.0034117994,-0.08376869,0.076948576,-0.06405042,0.0002647451,-0.029713778,0.045225583,-0.004649976,-0.07203615,-0.075165376,0.008694704,0.021884074,-3.299978e-33,0.109414466,-0.022159414,0.033401106,-0.0860844,0.034014594,0.095138766,-0.01887811,0.031235645,-0.013075479,0.073667,0.04049727,-0.022113543,-0.0033528828,-0.012216787,0.008906334,0.046123732,0.06714829,0.12638804,-0.036651187,0.030986305,0.0067647286,0.088142194,0.013609603,-0.075158134,0.0055389893,-0.0071734698,0.03151756,0.0495723,-0.021145862,-0.016593855,-0.04706052,-0.07187421,-0.042772405,-0.08704159,-0.09195538,0.06291377,-0.048550535,-0.0850786,0.021250766,-0.029647624,0.01969278,0.008141103,-0.04734401,0.081505984,0.06349914,-0.0046249167,-0.06898534,0.08405318,-0.010651551,-0.0021250248,-0.0005419592,-0.021355977,0.037937865,-0.045973778,-0.016337443,-0.012519786,0.025936399,0.06382394,-0.012207032,-0.05403029,-0.04246128,-0.024239771,0.013478542,-0.0018903792,0.05658295,0.11522571,-0.07127503,-0.0014671688,0.04497235,-0.046173967,0.057670802,-0.027774349,-0.08438106,0.010356724,-0.017919531,0.0060604694,-0.06410041,-0.084865935,-0.01451835,0.038308453,0.02343588,-0.024803286,0.025865301,-0.010494609,-0.026879018,-0.03688093,0.043898527,0.009235996,0.031169262,0.047446366,0.016939636,0.007919257,-0.029469043,0.07506897,0.039028507,-2.6443715e-08,0.021011015,-0.063174434,0.01039455,-0.052760556,-0.023590231,-0.04624525,0.0042482074,-0.012902965,-0.019008646,0.023915488,-0.059512142,0.05707127,-0.027503394,0.011285639,0.061549366,0.0031097902,-0.015940854,0.036727156,-0.013088289,-0.015437145,-0.017639358,-0.021857591,-0.0377316,0.009366576,0.06133004,-0.083069,-0.021362988,-0.08984904,-0.05494518,-0.032679364,0.030384663,0.040631596,-0.033333518,-0.0099813035,-0.024093175,0.024817735,-0.1349497,-0.022338599,-0.031054819,0.037641626,0.012894429,-0.0060640937,-0.019693494,0.03943008,-0.069969706,0.04978101,-0.024149274,-0.08487714,-0.03263365,-0.046683595,0.04084909,-0.057086684,0.0019689319,-0.036474213,-0.13928883,0.021171032,0.0040245103,-0.0680235,0.015959784,-0.04264129,-0.032398213,-0.009430942,0.22017401,0.00024808454 +2.5.1.121,"The enzyme is involved in the biosynthesis of prenylated phenazines by the bacterium Streptomyces anulatus. It is specific for both prenyl diphosphate and 5,10-dihydrophenazine-1-carboxylate.",384,1.0,-0.07715513,0.0023520123,-0.09157301,-0.04912828,-0.004554746,0.06537414,-0.025239408,0.06533607,0.0384375,0.07096406,-0.009508441,-0.01275085,-0.03164738,0.013459383,-0.054580584,-0.01802954,-0.08009026,-0.033427805,0.006189284,-0.000908124,0.09068535,0.04481631,0.023673382,-0.03815557,0.05697642,0.022807246,0.07652669,0.032183856,0.04592207,-0.062215343,0.030511564,0.000994687,0.068296425,-0.008258574,-0.0033323322,0.09586874,-0.06429618,-0.06485261,0.100052685,0.04868849,-0.0013285462,0.015008838,-0.08528328,-0.0026787368,-0.0613816,-0.014740599,0.03256279,0.12719019,-0.03620587,-0.008148659,-0.04365036,0.0016004092,-0.0012920587,0.0062648244,-0.018528223,-0.0021165174,-0.023678508,0.027130894,-0.042268924,0.017128276,0.03237977,0.0036257042,-0.064322814,-0.059764512,-0.0016844163,-0.008768175,0.0062416424,-0.024682183,0.055791132,-0.08222236,-0.08859904,-0.05666197,0.059695885,0.052889142,0.008752617,0.041999254,0.034812752,0.038092695,-0.03345246,-0.031214893,0.04994429,-0.055605628,-0.01279612,0.0095595615,0.07268906,0.012714045,-0.014918272,0.060395364,0.13798709,-0.012180676,-0.0020917796,-0.055550255,-0.030949183,-0.006316823,-0.12271388,0.04813645,-0.04528855,0.006451765,0.017063024,-0.0018539731,0.07135961,0.036265586,0.004244791,0.012277833,-0.053031817,-0.08018597,0.060241606,0.058151606,-0.029521994,-0.030924467,-0.034403127,-0.0023380197,0.033397544,-0.0086908275,-0.06680909,0.062106013,-0.015002172,-0.07318545,-0.06673635,-0.055480186,-0.016117001,0.0038030264,0.017781412,0.022460978,-0.037909262,0.0021919222,-0.18580961,2.9288481e-33,0.034696937,0.07494996,0.038993757,0.0115796635,-0.040071752,0.016094726,-0.10701688,0.035780758,-0.02059007,-0.084408365,-0.05382409,-0.09306554,0.014065824,-0.016490132,-0.03286258,-0.048912004,-0.028614627,0.001994322,0.091958694,-0.0048776004,-0.0327085,0.044354465,-0.08628497,0.07184579,0.082079105,0.10083163,-0.017879637,0.02711748,0.04994134,-0.020770509,0.043413695,-0.07834177,-0.060860746,-0.050790235,0.056125015,-0.027266959,-0.08395909,-0.024102405,-0.013375425,-0.0019773294,0.016145093,-0.0090478035,-0.014775157,0.0648081,0.0137084555,-0.039743766,-0.036803667,0.04420926,0.051889766,0.012484791,0.032448627,0.031286202,0.1107815,0.036191337,-0.12013668,0.08503992,-0.016317582,-0.043137453,0.07233099,0.034139868,0.02906434,0.037453625,-0.042545427,0.051750105,0.016164072,-0.003815736,-0.04094196,-0.0038253677,0.051611006,0.12440334,-0.07562474,-0.046834547,0.036353376,0.025415713,0.025257748,0.04707272,-0.0023966515,-0.033611186,0.015279762,-0.03952656,0.03766155,-0.019443924,-0.020417199,-0.029323181,-0.093413405,-0.0030739605,-0.006981521,-0.077413715,-0.004948781,-0.0033296014,0.10261069,-0.08895819,-0.053812113,-0.03118186,0.024516832,-3.904128e-33,0.089365296,-0.07126851,0.017587364,-0.028734116,0.02438701,0.08130088,0.041984726,-0.0985087,-0.05214165,0.0025532476,-0.0014610281,-0.041864175,-0.00992208,-0.03357505,0.026410526,0.042994823,0.06194922,0.017696835,0.06481798,0.048128586,-0.0070840237,0.0817343,0.029054778,0.004660607,-0.03833466,0.029675763,0.05552901,0.054994524,0.0074738543,0.07143727,0.019842485,-0.008406087,-0.018249128,-0.091130264,-0.039430477,0.058007363,-0.06708007,0.017084327,0.0031654532,-0.013863013,0.020307435,-0.01333997,0.01097177,0.019857127,0.016903957,0.03237002,-0.05600406,0.013226562,-0.043302953,-0.033472538,0.02211517,0.10939865,-0.00045317868,-0.06264502,0.06930846,-0.048086204,-0.019719437,-0.08129624,0.042497363,0.0025520301,-0.027698055,-0.08605115,0.011134604,-0.031889185,0.039668042,-0.043047376,0.02187931,0.12703656,0.09818568,-0.04922516,0.061679956,0.012404573,0.012470559,0.0490519,-0.10259421,0.04211366,-0.043338448,-0.026576474,0.030106567,0.007891446,-0.036758646,-0.05917787,0.034932517,-0.043272957,-0.0628204,-0.047488693,0.048580743,0.020416293,0.02625412,0.070396826,0.002466775,0.007772439,0.05617821,0.06679653,0.0073642507,-3.4752972e-08,0.05718745,-0.093350224,0.050502427,-0.020008948,0.02682971,-0.038016353,-0.022910472,-0.0025056934,0.004254126,-0.033473387,-0.022888001,-0.024969315,0.013182338,0.022819579,0.053339705,0.01868932,-0.09882707,0.06820837,-0.054290004,0.02653937,-0.047013972,0.0565556,-0.1259632,0.009948378,0.08007221,-0.035012532,-0.0324578,-0.019883674,0.0071498826,0.015858876,0.023588417,0.031942118,0.026329663,-0.075795345,-0.08356912,0.0030073246,0.012690933,-0.024262978,-0.070132464,-0.0004372979,0.06403276,-0.014335239,-0.030754752,0.04835807,-0.08041206,0.058444187,0.018783145,-0.037888154,0.022195384,-0.05755357,0.014723645,0.07611069,-0.0051489715,0.0072895894,-0.1169361,-0.0051466064,-0.085304335,-0.02983815,-0.017748436,-0.05977451,-0.041204955,0.0737709,0.15976948,0.003726895 +2.5.1.122,The enzyme is involved in biosynthesis of the phytotoxin sirodesmin PL by the phytopathogenic ascomycete Leptosphaeria maculans. ,384,1.0,-0.06825973,-0.07494235,-0.058654513,-0.01116393,0.048695143,0.07678508,-0.117660224,0.043547068,0.041922215,-0.0110639045,0.014403355,-0.021341246,-0.0063084546,-0.0067127864,-0.07427172,0.023302395,-0.033605102,0.038091946,-0.027125062,-0.042965468,0.121126994,0.035483602,-0.0003527261,-0.0018985833,0.019606419,-0.023725856,0.05668545,0.0009309558,0.013249662,-0.04380316,-0.0011070673,-0.09808856,0.06581883,-0.04404967,-0.006011835,0.10666958,0.08941241,-0.006425125,0.03551405,-0.044893514,-0.00052399654,0.027267702,0.020051498,0.0049725613,-0.016046029,-0.01342372,-0.056466274,0.027301095,0.11162668,-0.052452803,-0.060863715,-0.06703173,-0.02883974,0.016154818,0.007325266,0.07889142,-0.015158569,-0.07118211,0.03263444,0.036411688,-0.041946348,-0.04618704,0.029359128,-0.0031496137,-0.009715747,-0.032987643,-0.05704669,-0.011392485,-0.0054024165,0.028786965,0.02088741,-0.058856122,-0.049178705,0.027062764,0.022424992,0.034908827,-0.03761958,-0.035847552,-0.006054816,-0.0015694782,0.032674316,0.018076964,0.08532104,0.097074084,0.020557463,-0.0505178,-0.009496983,0.035043247,-0.0016049545,0.024366267,0.013205564,-0.01580459,0.011901052,-0.0073080277,-0.011825933,0.075578675,0.027116792,0.065160334,0.021062925,-0.055936314,-0.00461404,0.039037094,-0.089010425,-0.08267909,0.00070774456,0.0148508465,-0.0004785005,0.057573427,0.050152633,0.007482097,0.029141696,0.002727836,-0.050620623,-0.008296914,-0.045919828,-0.007302998,0.052825663,-0.03517846,-0.08988451,-0.035453323,0.046770677,0.03048014,-0.03887479,0.07709871,-0.016579514,-0.014134676,-0.03873284,3.3703252e-33,0.016489256,0.010568688,-0.03975112,-0.011655287,0.03226256,-0.04441277,0.014442324,0.010690367,-0.013007568,-0.067911156,-0.06632557,-0.099223964,-0.09608892,0.01940044,-0.0035767984,-0.0043156687,0.03610091,-0.03409862,0.031339366,0.0022956918,0.06445915,0.009212626,-0.03325261,0.036624312,0.028629305,0.036966283,0.018384129,-0.010457277,0.05931691,-0.01328509,0.007139266,-0.059885815,-0.08511739,-0.032417644,0.01351877,-0.016985675,0.0022741233,-0.0514291,-0.06678744,0.004339779,-0.08737651,0.042330045,-0.079789974,-0.032341003,0.058117673,-0.027945822,-0.030538583,0.050273452,0.041404776,0.034197167,-0.046056937,0.025355674,0.14329842,-0.0050577247,0.01269144,-0.029300129,0.005242541,-0.022554383,-0.039210975,0.03157264,0.06599294,0.0068131527,0.009531461,0.09923803,0.032552835,-0.005588133,0.022306507,-0.022354914,0.011047831,0.099913545,-0.07037985,0.013088556,-0.06158542,-0.005294304,-0.03650052,-0.060894433,-0.040964477,-0.0074017914,-0.031151162,0.0418036,0.062767915,-0.017201452,-0.024693873,0.049469743,0.022102915,0.02577237,-0.0046065575,0.0037291686,0.0039594485,0.006674835,0.026763394,-0.061005875,-0.031673394,0.080896825,-0.12229737,-4.7587442e-33,0.07313557,-0.06627291,0.056623623,0.022131618,-0.09299261,0.08354868,-0.097044446,0.095040776,0.055985175,-0.014065095,-0.0028556322,-0.052241977,0.007893183,-0.042871933,-0.03764839,0.03960974,-0.009165168,0.10579574,-0.078140214,-0.015022929,-0.08833298,0.09583064,0.056011498,-0.0021176375,0.06923782,-0.010220524,-0.000940133,0.12174618,-0.048561055,0.09809417,0.013843375,0.037013102,-0.07305739,-0.056016978,-0.019480731,0.05795169,-0.003910098,0.0065915706,0.060149755,0.066347554,0.09172436,0.0383785,-0.024894962,-0.0006810719,0.0054263016,0.056456927,-0.099430785,0.0773737,0.011268244,-0.06703603,-0.018299233,0.008810613,-0.010450167,0.08309952,0.03499939,-0.068151906,0.005773789,0.05316084,0.03776562,-0.06910897,-0.059749987,-0.07693554,-0.043250307,0.008686081,0.013943541,0.12650166,-0.07944458,0.05343379,0.0073454934,0.03541535,0.04036336,0.011687125,0.04060205,0.034865946,-0.039495163,0.021196073,-0.064732715,-0.063848,-0.02500141,0.06288832,0.06286508,0.010898858,0.043185882,-0.07750572,-0.012247865,-0.026458208,0.09832728,0.113055386,-0.04715811,0.036683496,-0.014555674,-0.054056123,-0.058186997,0.04287026,-0.004637212,-2.7516734e-08,0.07160363,-0.0016147473,0.021868719,-0.12231803,-0.0003710308,0.015024938,-0.036374245,0.0003719386,-0.0015130681,0.0580676,-0.034348767,-0.00033707672,0.013504513,-0.004536539,0.006330108,0.008925986,-0.009145183,0.09558221,0.048205726,-0.013153313,-0.04276674,-0.0069896164,-0.050458744,0.072417274,0.014585873,-0.04481899,0.04881932,0.017268946,0.03507388,0.0033754776,-0.0055777,0.01578524,-9.512366e-05,-0.019955466,-0.11997107,0.03290671,-0.09919338,-0.056459036,0.055481825,-0.06447502,-0.03691139,-0.072259955,-0.04034847,0.0028509717,-0.04041196,0.0044436287,0.061865814,0.02531038,-0.02188203,-0.018836435,0.024413224,-0.08006116,0.058185734,-0.08733805,-0.112035766,-0.014237189,0.050957087,-0.1287186,0.011681434,-0.13660505,-0.0057953503,-0.0015567954,0.19232549,-0.03848489 +2.5.1.123,Does not require Mg2+ or any other metal ions. Isolated from the bacterium Streptomyces cinnamonensis. In vitro the enzyme also forms traces of 3-geranylflaviolin.,384,0.99999994,-0.0518052,-0.039854668,-0.07109632,0.040241078,0.01923524,-0.031268205,0.034544546,0.030187393,-0.0052937986,-0.043817993,0.052088663,-0.050228897,0.040292934,0.028517265,-0.008379913,-0.08026444,0.0031366074,0.08657596,0.010194222,0.0038975973,0.098908246,0.008176633,0.0064716283,-0.0298343,0.015504159,0.06470308,0.028102344,-0.029857771,0.039852787,0.012255521,0.01359328,-0.0076104794,0.05212851,-0.07964328,0.07560333,0.04573573,-0.09490706,0.01391809,0.040717117,-0.019802585,0.0035819889,0.015780702,0.10989144,0.01794963,-0.009857098,-0.08281211,0.0943557,-0.036991134,0.00037292257,0.023219043,-0.060733613,-0.019451529,-0.038135216,0.032249045,0.04172894,-0.035776746,-0.06999412,-0.041241568,-0.01884666,0.0010874784,0.028344037,0.014012788,-0.003277553,-0.03997979,-0.042266786,0.038278565,0.011676468,-0.052366447,0.11462321,-0.019276474,-0.0029423,-0.031739622,-0.0036539554,0.024070058,-0.09080375,0.0679433,0.075353116,-0.05260817,0.022011587,0.010402625,0.032028656,0.029379828,0.07442867,0.097183466,0.018170297,0.009386579,0.026236389,0.094421156,-0.03588671,0.08327207,0.10720408,0.042086855,0.018915175,-0.047239777,-0.065051965,0.054729186,-0.083885744,0.016165668,0.02296,0.02685959,-0.010377336,0.045756634,0.043557055,0.019024799,-0.054729175,0.017140793,-0.07295911,-0.023939896,0.00900926,0.020107757,0.051795445,0.0241573,-0.028717482,0.007113533,0.042339813,0.041223027,0.08387851,-0.10196039,-0.04805585,0.03658009,0.028585156,-0.018435836,0.03180173,-0.011865207,0.033242952,0.028619882,-0.02764207,1.9384785e-33,-0.07241004,0.03020745,0.058602713,-0.005060875,-0.011767243,0.025555609,-0.03151443,0.0034767608,-0.012111747,-0.023806524,-0.11277823,-0.027232733,-0.021853955,0.01421017,-0.013134925,0.022804232,-0.022854656,-0.026387217,0.16562395,-0.009612578,0.0077342982,0.045834173,0.007293064,-0.035235904,0.031922672,0.103661895,-0.0021615375,-0.089978725,0.09990349,-0.0079787,0.07909203,-0.10295247,-0.056252375,0.035825245,0.0334079,0.0063977772,-0.0687564,-0.071001865,-0.01760103,0.023081731,-0.023236359,0.056414273,-0.013563743,0.054309487,0.069241814,-0.09717031,-0.07260716,0.076483205,0.034285773,0.05955437,0.049709182,0.021680424,0.029040972,-0.0081892125,-0.10343728,0.0454472,0.002757778,0.073540695,0.08509165,0.042671595,-0.02248411,0.054895405,-0.021588791,0.048288144,0.100337125,0.04382894,-0.069201216,-0.05273921,-0.032879878,0.063688375,-0.048999194,-0.09717489,0.01488765,0.014162998,-0.023375358,0.0003767661,-0.06654704,-0.012440988,0.07453157,-0.01688557,-0.06759812,-0.043742042,0.030696318,0.011124546,-0.08553242,0.022328068,-0.070578516,-0.018107446,0.0074383197,0.008825876,0.009610575,-0.0062567056,-0.112149425,0.034121983,-0.025897611,-3.270147e-33,0.049219124,-0.028763708,0.05340109,-0.0367415,-0.07754821,0.08142716,-0.0051121074,-0.05509755,0.031345233,0.032637566,0.09180843,-0.022459155,0.008812184,-0.08955395,-0.0003003336,-0.030074475,-0.010600094,0.15623242,0.0014538418,-0.002360335,-0.0041236365,0.09113779,0.00025776404,-0.012433932,0.04350021,0.0020150524,0.06660305,0.008687732,0.0031745355,0.062183022,0.021222224,0.045381,-0.005939956,-0.12875754,-0.081494175,-0.019071007,0.00814478,-0.011858026,0.004714907,0.04182639,-0.015437878,0.05907361,0.08606195,0.115970634,0.0060711578,0.064770244,-0.06419955,0.04947379,0.06703961,-0.07381861,-0.0020576187,-0.018294064,-0.11826705,-0.08320292,0.021914816,-0.0065091397,0.011806743,-0.060909413,0.0024629482,-0.042728864,-0.014255892,-0.031863727,0.013175055,-0.08241406,0.04796698,0.064510465,0.04818082,0.057391223,-0.004614345,-0.009070788,0.062222585,0.009544658,0.024895417,-0.03186692,-0.025572535,0.08551237,-0.060459442,-0.044387043,0.05889698,-0.07484249,0.06554874,0.011786354,0.013593417,-0.025776984,0.041043155,-0.13697594,-0.0144315185,0.046551503,0.0044717523,2.9136203e-05,-0.07790117,-0.017758789,-0.03303056,-0.021407718,0.0021975543,-3.0078976e-08,-0.04501636,-0.028179137,0.06023623,-0.050784953,-0.005898821,0.0689572,-0.07413325,-0.02145129,0.045077566,-0.010349029,0.0045829727,-0.04295835,-0.07829582,-0.022714306,-0.02620261,0.022634722,-0.026400642,-0.0064112716,-0.07000443,-0.05787179,-0.07667087,-0.0075184167,-0.063535355,0.024460778,0.033098537,-0.066532254,0.03390344,0.03473018,0.002508339,-0.018717308,-0.035354298,-0.01630064,0.007011498,0.018773137,-0.06589584,-0.022272302,-0.05260484,-0.059956487,-0.04839966,-0.082260504,-0.04710289,-0.076042525,0.009060042,-0.016245345,-0.055575993,0.0013133095,-0.057963092,0.025413807,-0.06174359,-0.010218955,0.06802759,-0.063380644,-0.028128155,-0.017225737,-0.08251724,0.04230211,0.044281434,-0.08419258,-0.049479872,-0.10625855,0.015076095,-0.04726978,0.10390761,0.019682888 +2.7.1.183,"In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.",384,0.99999994,-0.10842204,-0.08752948,-0.14826883,-0.024009401,-0.01317628,0.0039828853,0.06334238,0.06673027,0.053183876,0.035823032,0.02556431,0.043201804,-0.04923187,0.036398027,-0.10156902,-0.09314266,-0.024275409,-0.009259843,0.01790996,0.027228542,0.016807262,0.011966583,-0.026397174,0.02618714,-0.03515395,-0.02174072,0.0058214935,-0.037697643,0.0065399194,-0.01868024,-0.017610775,-0.018403279,0.027011,0.03222948,0.004339103,0.07530574,-0.011304076,0.009496859,-0.009895775,-0.053633396,0.10596405,-0.049088914,0.037367914,0.04161696,0.048690677,-0.047862966,-0.059317525,0.0055644303,0.021065528,0.121662,0.014818355,-0.016341936,-0.009395925,0.066840604,-0.0024854415,0.040022913,-0.016074462,0.081530266,0.07674871,0.049795754,6.005115e-05,-0.07215028,0.03522218,0.020812443,0.048716266,-0.11842897,0.013912231,-0.06340575,-0.07393438,0.0644626,0.028860955,0.02103016,0.0021754224,0.04241762,0.038352262,0.010572868,-0.055365868,0.016678076,-0.015457277,0.027146956,0.14900535,0.10791599,0.10464126,0.12599225,-0.051552337,0.0029862379,-0.0060895695,0.0076879524,-0.005877496,-0.032257896,0.014334168,-0.003885339,-0.014662612,-0.028616363,-0.11608158,-0.052078452,0.047237813,0.015896043,-0.03837291,-0.037287682,-0.025960056,-0.008813535,-0.013585565,-0.036731146,-0.08367818,0.08255083,-0.027660511,0.022291241,0.10039159,-0.032498278,-0.017900469,0.051179703,-0.023473717,0.023447558,-0.06021959,0.0061370046,0.09315186,-0.12238951,0.02878501,-0.073083766,-0.01771027,-0.043665405,0.06385542,0.021433432,-0.03196093,0.0066492744,-0.060646236,2.3646718e-33,0.025453202,0.02017471,0.04516071,0.033632938,-0.03577998,-0.03412821,-0.011444885,-0.0912794,-0.019703357,-0.06260854,-0.008076596,-0.0060927602,-0.010100488,0.16270746,-0.069237806,0.081556715,-0.03263565,-0.070879884,0.028601965,-0.09919275,-0.0039950437,0.053222142,0.018136088,-0.039961297,0.11066844,0.061012253,-0.053220823,0.030804113,0.089863144,0.012055063,0.03197101,-0.020298379,-0.0045224414,0.020615451,0.07803965,0.043240774,-0.013145787,-0.013325822,0.06320082,0.059042037,0.040483918,-0.056825895,-0.028637081,-0.06611816,0.015944768,-0.041506946,0.029422661,0.02195311,-0.1138951,0.006044621,0.07692416,-0.05690699,-0.0102247335,-0.02007952,-0.102765135,0.036496866,-0.060093403,-0.10117084,0.012574883,0.03798127,0.056616772,-0.018995848,0.0053919326,0.002799628,-0.02792099,-0.035796504,-0.06899231,-0.054535735,0.019994894,0.002722993,-0.023743533,-0.053983584,0.10013622,0.014997701,-0.02754078,-0.0026836167,0.0025570684,0.06616635,-0.028704468,0.020088196,0.015651848,-0.051605865,0.009512646,0.023547873,-0.056383472,0.006576743,0.0412844,-0.12620483,-0.056644663,0.02015116,-0.01750932,-0.008891393,-0.037971772,0.061043948,-0.044884007,-4.7179527e-33,0.042902283,-0.08138299,0.02586461,-0.0031088062,-0.03328581,-0.031670608,0.01297958,-0.06057989,0.035686776,-0.019317966,0.034740478,-0.007151995,0.0129035795,0.034935907,0.098984644,0.014111928,-0.07549049,9.896318e-05,-0.03589397,-0.07531477,0.028949855,-0.045888584,0.03600678,0.0709714,0.064675726,0.02513679,-0.03744848,0.020084899,0.02408203,0.06418904,-0.11742277,-0.0354557,-0.045693424,-0.06756354,0.015399667,0.03842172,-0.003546133,-0.01283946,-0.024052145,-0.04827319,-0.013494181,0.027307933,0.071578935,0.00979976,0.03932417,0.06359444,0.06968975,0.08238904,-0.06287734,0.026270242,0.028715467,-0.011915879,-0.036432084,0.114850245,-0.0011412691,0.088039555,0.04013413,0.06664545,0.02771191,-0.03913911,-0.06575553,-0.042083297,-0.095283434,-0.025226332,0.10365971,0.032735232,-0.01938585,-0.034375925,0.025939278,0.0045477175,0.04665072,0.0066889147,-0.02712386,0.017572463,-0.042111862,-0.04021957,-0.12654237,-0.07755799,-0.0056921854,-0.022653678,-0.069770955,0.019578107,-0.010872705,-0.06664343,0.061533682,-0.0035130451,0.022654738,0.09379399,-0.03167681,-0.026929084,-0.017259682,-0.026647303,-0.0830276,0.00087031734,-0.023102466,-3.857581e-08,0.027895682,0.02103657,-0.09752754,-0.10787508,-0.012989268,-0.045588,0.04150053,0.07327595,-0.010706247,0.029317887,0.021799296,0.034548294,0.04675951,-0.055131976,0.010771465,0.059972413,-0.04195769,0.0057397964,-0.035362665,-0.0091649145,-0.021016108,-0.012911205,-0.09912112,0.045605253,-0.076513596,-0.03847069,0.0005235426,0.051132582,-0.029892487,-0.018368859,0.056803532,0.024890432,-0.03423945,-0.021844685,-0.0113054,0.049511656,0.006792246,-0.016379336,0.04153523,-0.04608205,-0.022474656,0.07650849,-0.0025695653,0.030066196,-0.056406356,-0.013261427,0.040217012,0.017407605,-0.013229442,0.051920623,-0.0149505045,-0.060674362,-0.0069105444,-0.038809747,-0.06551483,-0.07873222,-0.018692985,0.035697695,0.053813886,-0.009065851,-0.015120519,0.047939442,0.09476717,-0.0111215785 +2.7.1.184,"The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea.",384,1.0,-0.081105225,-0.048594564,-0.10848376,0.008835624,0.046745438,0.032828197,-0.049831737,0.032870505,0.07586287,-0.02913979,0.05445136,0.009486292,-0.059808504,0.07226813,-0.03937746,0.070400394,-0.1304683,0.029386794,-0.024048015,-0.028893366,0.05958483,0.045026932,-0.09444737,-0.0056915265,0.019239303,0.0630403,-0.059983052,-0.049416408,-0.09797374,-0.008290234,0.027908891,0.012696363,0.057618678,-0.035901356,0.07355347,0.1522308,0.028199598,-0.10104334,0.0683804,-0.004423828,-0.018378016,0.0072768857,-0.054817714,-0.0065369243,-0.035815757,0.026034571,0.010792563,0.058089305,0.060984876,-0.13011214,-0.068549275,-0.03453788,-0.06960186,0.019426117,0.028898627,0.030748924,0.051367465,-0.029543107,-0.014377658,-0.030635532,0.01817062,0.004598654,0.024005316,0.0049432805,0.0040045623,-0.025003677,0.03586843,-0.061665494,0.07767121,-0.002634982,-0.10855647,-0.034419484,-0.04132187,-0.021449795,-0.053963292,0.058112852,0.002740639,-0.045448102,0.0063986606,-0.06776737,0.061440136,0.03541591,0.023777848,0.08512765,0.048423767,-0.024969043,0.06765369,-0.050296754,0.067554966,0.02532024,-0.0014836654,-0.05090578,-0.008883265,-0.07645724,-0.05743536,0.025233941,0.013815054,-0.021189751,-0.0104850605,-0.013478761,0.018099561,-0.024771795,-0.048207175,-0.114914246,-0.0254176,0.018596342,0.014751947,0.06833244,-0.0031445203,0.001346658,-0.044024188,0.0033087449,-0.02154747,-0.011625926,-0.018472224,0.054106038,0.08257015,0.0059516155,-0.1299897,0.10004439,-0.07007859,-0.013911042,0.0050511532,0.0149930725,-0.0122365225,0.08648806,-0.14280026,1.1601745e-33,0.123134084,0.01616118,0.05361562,-0.07913103,-0.025008857,-0.04411759,-0.050337482,0.01412914,-0.03370879,-0.056220617,-0.059754733,-0.06865937,0.008383214,-0.015326728,-0.007194241,0.021339592,-0.053300068,0.03258519,0.017026197,0.004868905,-0.06462804,0.012327643,-0.01905368,-0.06327321,0.034399852,0.026704304,0.012897256,-0.03153275,-0.028984167,-0.00077295443,0.09466792,-0.09642048,-0.12007767,0.04579283,0.13495424,-0.0058387783,-0.009034631,-0.026895141,-0.01834693,0.027129447,-0.046964817,0.062556654,0.037711397,0.0032459437,0.027164161,-0.020968975,-0.045867275,0.09211938,0.03900813,0.06517287,-0.03568121,-0.012652869,0.07132777,-0.017910345,-0.011031827,-0.02958268,0.014312298,0.016845088,0.003154783,0.0004091409,0.03579222,0.044870023,-0.07905116,-0.033796947,0.05636474,0.07166189,-0.024296843,0.05565058,0.022828927,0.032644838,-0.06066331,-0.07223315,-0.019470055,0.07090165,0.036945608,-0.030262005,-0.026062299,-0.002204743,0.012109821,0.030730639,-0.042406786,-0.06855791,-0.0038989258,-0.09200474,-0.107197665,0.024448235,0.010689955,-0.0024143988,-0.071096554,0.018730402,0.010029817,-0.032258693,-0.0031681375,0.009040636,-0.0059305755,-2.7808596e-33,0.015003369,-0.05452655,0.023027115,-0.11637855,-0.093934,0.03149038,-0.06955213,-0.008205699,-0.0065954006,0.06255354,0.014117333,0.06334124,0.03594257,-0.046110697,-0.017452555,0.013863838,0.04405759,-0.027869068,0.029875813,-0.029873336,-0.008636987,0.10606709,0.046726547,0.022122815,0.023141013,0.018018931,0.0035001736,0.02622125,0.063791856,0.01568855,0.013999732,0.00057380646,-0.001937919,0.0029858793,-0.07605887,0.007589528,-0.046934437,-0.022978526,0.04898236,0.031662956,0.044483267,-0.03377986,0.060680397,0.07631676,0.018495454,0.0053169583,-0.09346859,0.07669296,-0.007932083,-0.0059235473,-0.02240669,0.027454212,0.015097388,0.04584151,0.018141516,0.023740614,-0.0030809965,0.03453002,-0.058558963,-0.029093096,0.03317917,-0.055878572,-0.00011734147,0.027557913,0.023823801,0.061577402,0.014241196,-0.011455841,0.0041630627,-0.023307366,0.04750189,0.0108008385,0.0051804595,0.0019943805,-0.059286524,-0.018024353,-0.05478696,0.017430909,-0.027145715,0.017571095,0.03176348,0.034560975,0.0026827103,-0.080313444,0.06640434,-0.10730782,0.014470957,0.045994163,-0.025761962,0.012708649,0.0050877533,-0.0109651815,-0.057757158,0.044751782,0.04352304,-3.234832e-08,0.035897054,-0.01923053,0.087022826,-0.020596482,0.00695203,-0.019256637,0.04693385,0.093760826,0.06628972,0.045912772,-0.0037790635,0.09116307,0.032803293,-0.01146838,0.09288415,0.028900972,0.016244136,-0.019734358,-0.014771229,0.0028765146,-0.021691596,-0.10516877,-0.10397288,0.040435523,0.02400715,-0.061237276,0.11301135,-0.0095522385,-0.06994482,-0.014365158,0.053652797,0.033525847,-0.020851094,-0.041746866,-0.04165446,0.03375187,-0.09469202,-0.07120259,-0.03269431,0.05770823,-0.025293592,0.05529502,-0.09381548,0.03377349,0.0580351,0.07190426,0.06753908,0.042631783,-0.06782231,0.030712964,0.062613115,-0.032731947,0.027466508,-0.051476676,-0.15002768,0.031094102,0.08546457,-0.02689769,0.00089231535,0.04779797,-0.0015588738,-0.030498687,0.14564575,-0.013327105 +2.8.2.37,The sulfation of trehalose in the bacterium Mycobacterium tuberculosis is required for the biosynthesis of sulfolipid-1. 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+3.1.1.96,"The enzyme, found in all domains of life, can cleave mischarged glycyl-tRNAAla [5]. The enzyme from Escherichia coli can cleave D-tyrosyl-tRNATyr, D-aspartyl-tRNAAsp and D-tryptophanyl-tRNATrp [1]. Whereas the enzyme from the archaeon Pyrococcus abyssi is a zinc protein, the enzyme from Escherichia coli does not carry any zinc 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+3.1.4.57,"The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.",384,0.99999994,0.017509948,0.028795626,-0.042015806,-0.05765197,0.019770157,0.052775335,-0.07625814,0.056649424,0.015455932,0.00888345,-0.050719798,-0.0056799003,-0.015166877,0.019109173,-0.07606768,0.036910925,-0.06704074,-0.011364718,-0.0426692,0.048692867,0.050461702,0.052769896,-0.01874386,-0.029983982,0.049679503,0.057808615,0.020297285,-0.039324503,-0.048797324,-0.020548271,-0.030154226,0.06364084,0.05586754,-0.104507476,0.0494904,0.16122282,0.03287388,-0.0668694,0.02903751,-0.038053017,0.039782304,0.031080518,-0.055683028,-0.055072293,-0.055769257,0.011187163,-0.00034397157,-0.035692334,0.06376981,0.03043145,-0.05798223,-0.0832542,0.0381968,0.03792308,-0.052793726,0.052734833,-0.004836275,-0.0031876247,-0.0792737,0.011459627,0.04931713,0.025543869,-0.0410874,0.047678158,0.059748426,-0.01926119,0.07792549,-0.05129341,-0.0036409625,-0.018587567,-0.06691902,-0.050450627,-0.009596152,0.059025582,-0.027726939,0.044839833,0.022846399,-0.04731905,0.06901813,-0.03522683,-0.028387034,-0.020634212,0.02897628,-0.0047500343,0.022140536,0.056289293,0.019669548,-0.028247437,0.09313893,0.027641885,-0.008786012,0.038904607,0.031924896,-0.08484744,0.05773739,0.032927193,-0.017429352,-0.008533458,0.04257428,0.0077183624,-0.008965053,0.025220642,-0.07082077,-0.114422366,-0.01852893,0.01802248,-0.057463035,0.015614711,0.009322346,0.00094945665,-0.009652845,0.040383242,0.060495753,-0.0037326987,0.009090503,0.0742062,0.048276518,-0.027238056,-0.123007745,0.018180218,0.00827335,-0.13530183,0.055566106,-0.0178496,-0.061630394,0.032514554,-0.07849624,-1.4684943e-33,0.07483628,-0.012786087,0.04632924,-0.12163187,0.09888268,-0.011348321,0.0037454392,0.053846445,-0.017878965,-0.11794209,-0.019225243,-0.056676593,-0.01811022,-0.026231332,0.014842989,0.056395516,0.04650463,0.0605076,-0.0044136094,-0.038491115,0.041585695,0.031221813,0.014087243,-0.022089643,-0.012548579,0.020333186,0.05763577,-0.025959807,-0.0037871418,-0.022502977,0.03961848,-0.09107832,-0.08303864,-0.04871752,0.05957784,0.0018225375,-0.020984558,0.0048533725,-0.007364173,0.08226826,0.05344902,-0.009212587,0.023382444,-0.012294905,0.00052542606,-0.069739684,-0.07499483,0.06503525,0.024899414,0.033297744,0.06459463,-0.017911434,0.010260856,-0.010731233,-0.055176992,0.027603533,0.03322049,-0.052445877,-0.015471342,0.01503514,-0.04255406,0.008610295,0.009600311,0.05470347,-0.0009770865,-0.071070164,-0.10247741,-0.059089173,-0.03392295,0.058968443,-0.03495624,-0.091807224,-0.05049366,0.056673855,-0.030027607,-0.053303506,-0.04355597,-0.0051489756,0.042190813,0.0040947935,0.034895357,0.043198112,-0.0013585681,-0.079141304,-0.07600013,-0.028270585,0.03210811,-0.1199136,-0.028227039,-0.010877848,0.04634562,-0.024181094,-0.03829418,-0.0044784104,-0.057625182,-1.480603e-33,0.05995183,-0.04074035,0.051887657,-0.04490743,-0.019984363,0.063817374,0.004938731,0.089799814,0.0032074288,-0.082317315,0.03645426,-0.024091803,0.07190077,0.019139268,-0.014496465,0.003016009,0.07262029,0.060108043,0.009031409,-0.050995175,0.010486477,0.08421995,0.049819387,0.03626252,0.0042235553,-0.0701606,-0.07284527,0.06805323,0.016374184,0.060322978,0.02140947,0.035064634,-0.027938306,-0.0014392483,-0.016663136,0.11499422,-0.0019864803,-0.049397655,0.069578685,0.026009688,0.04537496,0.0061958013,0.025522828,0.0030970732,0.015240587,0.014616902,-0.08321427,0.031814776,-0.030811066,-0.0067716455,0.08361296,-0.038119785,0.04718153,0.028323472,0.040063914,0.03388275,-0.035241533,0.005832168,-0.064900726,-0.011743721,0.013437153,-0.04920193,0.029616745,0.017817073,0.05220233,0.077089444,0.04136614,0.03375562,-0.03087254,-0.043121047,0.08236702,0.04357865,-0.007015642,0.11832407,-0.054679643,-0.05751577,-0.1013275,-0.035273373,-0.012889227,-0.055511277,-0.0015728622,0.044647004,0.003861802,-0.115885176,-0.039317023,-0.051488776,0.07189507,0.052143395,-0.039511025,0.055526663,-0.06005457,-0.03739797,-0.11924989,0.06559093,0.09805129,-2.512155e-08,0.08810491,-0.05867392,0.013740833,-0.046044126,-0.01610558,0.0010633531,0.032245338,0.0046047783,0.091480635,-0.0644965,-0.04200087,0.033262786,-0.02276313,0.013350365,-0.01209377,0.0330005,-0.032481298,0.061394695,-0.055071395,-0.03295409,-0.016847894,0.045635268,0.037386015,0.023551706,0.024207424,0.009082205,0.060433596,0.060507648,-0.0323595,-0.007896922,-0.047640264,0.052085124,0.018821271,-0.033766527,-0.1188725,0.032588277,-0.021175392,-0.030524962,-0.054370176,0.07679522,-0.0028866413,0.071363404,-0.09490245,0.0047890577,0.019397393,-0.054119464,0.031584308,0.028559914,-0.026080865,-0.052379034,0.066263266,0.047606133,0.0019704094,-0.090048015,-0.120101705,-0.0002134802,-0.031423684,-0.0027481657,-0.046234902,-0.028581418,0.019434761,-0.06260916,0.2159846,-0.057814527 +3.1.12.1,"Preference for single-stranded DNA. The enzyme from the archaeon Sulfolobus solfataricus contains a [4Fe-4S] cluster and requires a divalent metal cation, such as Mg2+ or Mn2+, for activity. 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It degrades linear or cyclic oligomers of poly(6-aminohexanoate) with a degree of polymerization greater than three (n > 3) by endo-type cleavage, to oligomers of a length of two or more (2 <= x < n). It shows negligible activity with N-(6-aminohexanoyl)-6-aminohexanoate (cf. EC 3.5.1.46, 6-aminohexanoate-oligomer exo hydrolase) or with 1,8-diazacyclotetradecane-2,9-dione (cf. EC 3.5.2.12, 6-aminohexanoate-cyclic-dimer hydrolase). ",384,1.0,0.009619548,-0.036553755,0.03885471,0.01163414,0.05932832,0.03079872,0.019322747,-0.0034785334,0.05899639,0.05143047,-0.08176671,0.10977834,-0.009226976,0.08819522,-0.06680557,0.10322031,-0.0837129,0.000639667,-0.020185588,0.04596005,0.055208515,-0.012407085,0.034280583,0.034571297,0.06514348,-0.038120102,0.023821596,-0.03451147,-0.024009481,-0.010630911,0.020051014,-0.00922898,0.0132514415,-0.010920457,0.0591892,0.11479743,-0.045362145,-0.06824843,-0.06889727,0.0233447,0.06442862,0.024927862,-0.041240044,-0.08617183,-0.015451821,-0.03061557,-0.07029612,0.033245087,0.01875645,0.01699434,-0.0093392655,-0.05045621,0.0033456625,-0.020671085,0.058010314,0.011876925,-0.060762715,-0.073149174,-0.07606172,0.045726407,0.065548845,0.041930303,0.016416956,0.023377273,0.01285123,0.03985879,0.09267721,0.00902004,-0.009236716,0.021163922,-0.118424214,-0.008004431,-0.02071347,-0.040396847,0.037905954,-0.069096126,-0.009561823,-0.048392452,-0.006545417,-0.060003974,-0.0062543815,-0.025891908,0.05027689,0.047852445,0.019073382,0.11207936,0.037741423,0.020786164,0.028958322,0.016344195,-0.009275657,-0.000499492,-0.00074329594,-0.101185024,0.027865373,-0.022679472,-0.012503628,0.04804578,0.070687816,0.011436334,0.0062280367,-0.01753873,-0.023040308,-0.11526062,0.008908401,0.045196723,0.031965185,0.102606006,0.033489738,0.035171684,-0.06024935,-0.02094486,0.09335715,-0.02748501,-0.07915717,0.11040242,0.0064191096,0.055375047,-0.012933994,0.03864176,0.007381357,0.003827514,0.06216296,0.033543542,-0.043294266,0.06499255,-0.012045071,4.076562e-33,-0.012307494,-0.020277113,0.035039432,0.013311415,0.01717053,0.045580633,-0.007340754,0.0008525429,-0.07367494,-0.05888689,-0.023171926,0.010354369,0.009073408,-0.0024113313,0.12732564,0.033523615,0.00015928526,0.043357108,0.030597871,-0.005300335,0.019612886,0.030341825,-0.0686732,0.033704165,-0.019978361,0.020847877,-0.010823705,0.039807823,-0.043030433,-0.03945579,0.045342684,-0.0007425032,-0.12427566,0.030225532,0.024697676,0.009196701,-0.06618595,0.016716277,-0.00461155,0.058794603,0.043967735,0.03563143,0.003992454,0.041638043,-0.006317197,-0.055756383,0.08403401,0.0974804,0.015486705,0.0009605409,0.03659218,0.03986188,0.052672956,-0.06713463,-0.06119217,-0.012509141,0.024375405,-0.03880144,0.019769236,0.001971575,0.017922582,-0.015059836,-0.0406181,-0.045942146,0.004167877,-0.051921472,0.037785295,0.06051424,-0.0034148274,0.05487215,-0.053137362,0.00471731,-0.0026641157,0.059025552,0.05246514,-0.046690922,-0.056640573,-0.06887254,0.054456566,-0.02532551,0.067860834,0.012344467,0.043688454,-0.05523057,-0.04641268,0.014585974,0.032056477,-0.043238588,-0.00959282,0.13988188,0.034377567,-0.16329521,-0.097434774,0.034402788,0.0067277006,-4.184179e-33,0.07307494,-0.008682327,-0.0004169744,0.005201586,-0.084769316,-0.06429174,0.049746223,0.08183154,-0.016193839,-0.13528459,0.13092631,0.00941994,0.07752914,0.026623918,0.023545614,0.043108165,-0.04059919,0.034822114,0.00871657,-0.081223786,-0.05427073,-0.014285761,-0.040989347,-0.046838973,0.033381216,0.04969569,-0.010084337,0.020707792,0.042842597,0.006435659,-0.027332349,-0.055462234,-0.013199688,0.035305522,-0.021116015,0.07206217,-0.06305445,-0.047657352,0.018275045,-0.018349396,-0.0054382817,-0.0037478125,0.05798739,-0.023620298,0.016266007,0.035763443,-0.11661935,-0.015306141,-0.0040416163,0.013175098,0.01658617,0.031349696,-0.062118553,0.03449449,0.013977566,0.027496502,0.031280756,-0.01649963,-0.0747169,0.029683013,0.0029791223,0.05679282,0.08224416,0.0678099,-0.015100139,0.08880441,0.0036600458,0.106831595,-0.057795644,-0.061678488,0.029935429,0.018824555,0.03330593,-0.016061725,-0.010412047,-0.030254962,-0.09190074,0.043190114,-0.03812753,-0.021999544,0.04193767,-0.06562657,-0.019323345,-0.027864598,-0.04220705,-0.05550812,0.12905928,0.04970722,-0.039142273,0.05555496,0.06461354,-0.059053276,-0.05603812,0.009181924,0.034993876,-4.5579267e-08,-0.028432908,-0.07926675,-0.018252544,-0.09928934,0.021159276,-0.015861299,0.01871504,-0.0073510283,-0.0029774387,-0.07351028,0.0054450496,0.032103032,-0.052961465,0.04310951,-0.01057626,-0.08522847,-0.06221032,-0.018454185,-0.027441159,-0.058277413,-0.12806803,-0.026186127,-0.03950826,0.006252681,-0.030429926,-0.03557942,0.028144836,0.037195288,0.026918402,-0.0429523,-0.056034014,0.011918651,-0.060204472,0.0012620549,-0.045401275,0.07792868,-0.021842588,-0.046403345,-0.051677026,0.077563316,0.036846697,-0.058960084,-0.034107197,-0.009746267,0.09043085,-0.050226673,0.011835462,-0.005835946,-0.0861726,0.022975147,0.08299616,-0.043694645,-0.040234722,-0.055743832,-0.081700236,-0.044962358,-0.004136533,-0.009960947,-0.050048783,-0.03738911,-0.06712464,-0.041594148,0.21678187,-0.0377076 +3.13.1.4,The enzyme from the beta-proteobacterium Advenella mimigardefordensis contains one non-covalently bound FAD per subunit.,384,1.0,-0.06709272,-0.08932456,-0.13392276,0.0024213775,0.05244437,0.004581489,-0.04783645,0.06022378,0.033329513,0.009157935,0.03583122,-0.022944659,-0.072669476,0.06269627,-0.009916829,0.005431244,-0.08278108,-0.013257962,0.032281734,0.0071695666,0.04711026,0.0031300648,-0.0025305767,-0.013993501,0.04051303,-0.015712539,0.072317526,-0.018990377,-0.009155515,-0.046613973,0.004058509,-0.028382853,0.07846468,-0.021838829,0.08574045,0.09466913,-0.020747,-0.10323933,0.056360878,-0.016465683,0.09369834,0.05712277,0.015410469,-0.03715034,-0.043886334,0.021332227,0.0056158244,0.089376464,0.09403648,-0.025905918,-0.05595488,-0.12125419,-0.07325616,0.017337665,-0.060906604,0.09115055,0.06993977,-0.046333052,-0.022446355,0.03154531,-0.012511061,0.001472157,0.043840263,0.012443405,0.04318464,-0.021358646,-0.060312383,-0.049177554,-0.034152497,0.00019120584,-0.019406663,-0.003603677,0.0078002727,0.03536953,0.036426507,0.035231724,-0.055545483,-0.038009662,0.06993126,-0.058778822,-0.010395139,-0.0022799673,0.045781717,0.048545487,0.02474377,-0.051124126,0.10162941,-0.0259223,0.060881782,0.042758554,0.007228604,0.020121222,-0.009979054,-0.041370332,-0.1113203,0.013794838,0.0022120844,0.043461196,-0.06388321,-0.049506173,-0.047362946,0.057788786,0.0381836,-0.054448694,-0.01215873,-0.07156166,-0.0083847,0.094574265,0.0332663,0.056014556,0.014287489,0.009229515,0.043188363,-0.06626994,-0.024122141,-0.06415853,-0.06289226,-0.07480285,-0.008526697,-0.028094055,-0.0143568,-0.015583801,0.00959345,0.03916846,0.06784217,0.06478738,-0.13211834,2.8886049e-33,0.07710195,0.0060066707,0.021028757,-0.0006033907,0.002754605,-0.013482398,-0.07380565,-0.033147547,-0.0075266045,0.018042734,-0.07703022,-0.041917767,0.017660504,-0.01354598,0.04195662,-0.00061367906,0.006935639,-0.039100304,0.056812994,0.025739672,-0.014877131,0.031164287,-0.05211607,-0.00016006659,0.055185035,0.02912244,-0.011990882,0.06731768,0.032339007,0.017257787,-0.003482096,-0.119557045,-0.13656546,0.04504272,0.040587675,0.0036492008,-0.037560996,-0.09084901,-0.08357822,-0.013086549,0.05007075,0.046610873,0.05423375,-0.0012664883,0.09613088,-0.09195757,-0.0057996344,0.07088773,0.0488656,0.10296378,0.03435417,-0.014780828,0.14344221,-0.026298402,-0.09510726,0.027247582,-0.038841035,0.049486395,0.04494283,0.012757809,-0.026149774,0.035973996,0.0043874555,0.06847876,-0.027966322,0.075112686,-0.04171866,-0.06566298,0.008967381,0.055210024,-0.01964574,0.0015608269,0.033109747,-0.013937248,-0.078832276,-0.030232916,0.05056392,-0.08541456,0.034097567,-0.043934114,-0.069133446,-0.012356261,0.018554434,0.01941128,-0.012210485,0.007202379,-0.0005193394,0.028854514,-0.008148534,-0.0010506589,0.11535373,-0.031093389,-0.08335978,0.07725756,-0.0021232588,-3.139053e-33,0.05335022,-0.092869714,0.06320592,-0.12739971,-0.052691463,0.05026286,-0.026328105,0.023966847,-0.006084404,-0.0693162,0.032991573,0.01583757,0.0017334246,-0.057677824,-0.010134393,0.021100271,0.0062175463,0.04805277,0.026916152,0.0012288553,0.013451062,0.07233767,0.07833191,0.01257503,0.004750145,-0.027155174,0.09111882,0.086384475,-0.012008885,0.021163015,0.05497024,0.07699372,-0.041356713,-0.08741246,-0.124688946,-0.04157871,0.012514011,0.004500898,0.08214495,0.011365164,-0.0025868916,0.012403596,-0.052152462,0.05213028,0.05056245,0.049403887,0.0117942635,-0.029877128,-0.011214705,-0.0066180318,-0.035917446,-0.09316877,0.012094143,-0.03010031,-0.00049760926,-0.02402205,-0.028852629,0.057067115,0.035162587,-0.05454154,0.036126424,-0.009649998,0.045801062,0.06866025,0.030299045,0.053555552,-0.0113500655,0.051962342,0.010304709,0.05840716,0.022620117,0.082822666,-0.1007293,0.022212321,0.001546167,0.0061781076,-0.070890315,-0.013224254,0.042524092,0.017215438,0.016682297,0.0030745964,-0.052704174,0.003001646,-0.048664052,-0.028045999,0.043609202,0.08304662,-0.06752974,0.08321879,-0.048148587,0.032388687,0.0062011685,0.022581318,0.053180184,-2.759782e-08,0.0661389,0.020214725,0.07668956,-0.062495954,0.05864578,0.024271907,-0.087127954,-0.039569475,0.04374565,0.009417389,-0.04252981,0.044562228,-0.047067814,-0.0074410536,-0.0074348752,0.01427904,-0.054751374,0.0017762925,-0.09671654,0.048831634,-0.03554187,0.038448073,-0.06084752,0.045634896,0.01439404,-0.07116905,0.052288942,-0.029268632,-0.07824403,0.03551089,-0.05343756,0.049758777,-0.063902326,-0.056401655,-0.06780011,0.0034573767,0.03347756,-0.032026783,-0.036071565,0.040260818,0.033879116,-0.085986465,-0.027647959,-0.018723333,-0.004345646,0.061073583,-0.0011012764,-0.044326637,-0.00964209,-0.031558037,0.041896574,-0.006539447,-0.06790012,-0.041178785,-0.13061288,0.033564504,-0.0024128698,-0.024774633,-0.08694871,0.0148828095,0.029672084,0.00806911,0.13726504,-0.027549192 +4.1.1.98,"The enzyme catalyses a step in prokaryotic ubiquinone biosynthesis, as well as in plastoquinone biosynthesis in cyanobacteria. The enzyme can accept substrates with different polyprenyl tail lengths in vitro, but uses a specific length in vivo, which is determined by the polyprenyl diphosphate synthase that exists in the specific organism. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.",384,1.0,-0.07486866,0.0030568251,-0.07984794,-0.027698865,0.039270833,0.06010216,-0.06308267,0.08153263,-0.010595854,-0.050115116,0.050550893,-0.047708314,-0.08906671,0.011552116,-0.056187477,0.04450763,-0.11287861,0.033358723,0.011414725,0.006622378,0.116731584,-0.012818331,-0.006559723,0.038569137,0.0007531698,-0.03662537,0.00655531,0.04601111,0.025478562,-0.017449459,0.00989474,-0.052443054,0.061092008,-0.086290814,0.039303258,0.08791335,-0.010096334,-0.13180794,0.05827528,0.0384693,0.10469504,-0.05661626,0.0100206025,0.06995957,0.045672808,0.03787432,0.031156993,0.10185493,0.04448935,0.049238034,-0.05206073,0.004943983,-0.02369424,0.026962647,0.03094808,0.03656981,-0.06767885,-0.00658595,0.011575412,-0.033446312,0.036856472,0.028181259,-0.02928378,0.020196998,0.01192771,-0.008252801,-0.05862615,-0.058910053,0.04972185,0.044747047,-0.0585957,-0.029833378,-0.09047298,0.057837464,-0.0643651,0.059209876,0.009018536,0.026844973,-0.030260095,-0.009650037,0.04602817,-0.022597807,0.04846756,0.003754787,0.013449696,-0.011456604,0.020713167,0.013933357,0.023765841,0.055677764,0.058873706,-0.023728304,0.01697142,-0.05990482,-0.09430792,0.06389202,0.056060392,0.05225427,0.04357497,-0.007072477,0.0059446003,-0.036902346,0.029322835,-0.04599575,-0.042692248,-0.023696264,-0.008480441,0.06447965,0.033650916,0.0045684166,0.019630764,0.0021132242,0.0067843823,-0.024465289,-0.029282529,0.050291233,-0.04622625,-0.07416357,-0.06460914,0.028618319,-0.025809985,-0.0076901806,0.05476321,0.08262023,-0.03251394,-0.018443512,-0.14611793,4.7022665e-33,0.07632398,0.012992519,0.021012295,-0.057923686,-0.02908741,0.004006238,-0.030509066,-0.005630261,-0.074362166,-0.0575036,-0.0489906,-0.024570346,0.037784602,0.022730462,0.0047715656,-0.029360801,0.012242957,-0.048609976,0.07937334,0.0022666291,-0.027781352,-0.05204862,-0.023021266,-0.022451043,-0.00071347307,0.041739367,-0.08301188,0.018202044,-0.024136018,0.01676242,-0.03033476,-0.101417646,-0.040668435,0.013476611,0.048625037,-0.110390894,-0.097706735,-0.10040506,-0.0022535145,0.060326133,0.0010891554,0.035465892,-0.013099464,0.0049954467,0.07941233,-0.026721526,-0.025158754,0.14114615,0.03673344,0.010571595,0.0641652,0.054214083,0.06069463,-0.026909266,-0.073052384,0.033409074,-0.00520771,-0.0054601426,0.0001405204,0.026967961,-0.03888102,0.06400165,-0.0067963195,0.02569793,-0.01636622,0.039513413,-0.03383877,-0.022663571,0.050103478,0.056189183,-0.030721707,-0.09089646,-0.027224956,0.040244274,0.044065177,-0.026393743,-0.012673026,-0.013534532,0.05375488,-0.009504053,-0.05554614,0.00054894586,-0.011340856,-0.050669316,-0.01987964,0.0045577553,-0.022545094,-0.07447873,-0.023608394,0.03388562,0.05284986,-0.045046493,-0.019792259,0.0036071134,0.027604263,-5.4097212e-33,0.08073981,-0.09044168,0.015658077,-0.036852274,-0.024971196,0.06459153,-0.0069614137,-0.005677573,0.014211206,0.043395482,0.036946874,-0.041430235,0.034654368,-0.008956548,0.0037893264,0.072087996,0.01489001,0.077791214,0.023168804,-0.034964968,0.06346495,0.02936828,0.024655657,0.020058002,-0.017590193,-0.025327764,-0.016720098,0.026543625,0.010557975,0.055544157,-0.078977734,-0.016747072,-0.08898978,-0.024704337,-0.036959298,-0.016538816,-0.028826583,0.07917298,0.09667108,0.037273154,0.08118749,-0.018282568,-0.029321402,0.015326551,-0.0035062393,0.07091686,-0.07886137,0.043685757,-0.0362829,-0.045149226,0.018016852,0.043370213,-0.033337638,0.010403706,-0.019371334,0.024664957,0.078330696,-0.0034300946,0.029996881,-0.0308487,-0.023375854,-0.15783003,0.0439919,-0.010096345,0.07554638,0.111519516,0.04430756,0.113144934,-0.024446035,-0.05099047,0.06810623,-0.032951813,0.0075971554,0.035660245,-0.07337652,0.07338588,-0.033862624,-0.10769264,0.007674764,-0.012099576,0.009822292,-0.056246217,0.030778147,-0.0691168,-0.059972487,-0.03502575,0.07528712,0.07298392,-0.03306402,0.097567715,-0.003195829,0.048204813,-0.009517196,0.025734758,0.074072115,-3.9654772e-08,0.013821144,-0.06817679,0.0761836,-0.030771887,0.040211823,0.093500905,-0.015047333,0.011119849,0.032806505,-0.017993342,-0.017909434,0.014604248,0.05706357,0.015465832,0.071136355,-0.017798137,0.011786459,0.018800655,-0.05676168,-0.014184497,-0.096755594,0.047375917,-0.083657965,-0.0011811362,-0.022240877,-0.0977928,0.041132774,0.073137805,-0.020971633,-0.019056004,0.000110150264,0.03724905,-0.06812379,-0.036105894,-0.12903583,-0.004197607,-0.018410046,-0.104020365,-0.0114393355,0.02136415,-0.09596231,-0.025907427,-0.012568676,0.04360315,-0.0029281422,0.003693007,0.07221605,0.043329787,-0.023941997,-0.006265174,0.052549094,-0.052601475,0.014210003,-0.11818522,-0.058042265,0.0068861097,-0.024831457,-0.028944863,-0.068066955,-0.06333734,-0.001956851,0.021979585,0.22306973,-0.054950833 +4.1.2.57,"The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea.",384,1.0,-0.081105225,-0.048594564,-0.10848376,0.008835624,0.046745438,0.032828197,-0.049831737,0.032870505,0.07586287,-0.02913979,0.05445136,0.009486292,-0.059808504,0.07226813,-0.03937746,0.070400394,-0.1304683,0.029386794,-0.024048015,-0.028893366,0.05958483,0.045026932,-0.09444737,-0.0056915265,0.019239303,0.0630403,-0.059983052,-0.049416408,-0.09797374,-0.008290234,0.027908891,0.012696363,0.057618678,-0.035901356,0.07355347,0.1522308,0.028199598,-0.10104334,0.0683804,-0.004423828,-0.018378016,0.0072768857,-0.054817714,-0.0065369243,-0.035815757,0.026034571,0.010792563,0.058089305,0.060984876,-0.13011214,-0.068549275,-0.03453788,-0.06960186,0.019426117,0.028898627,0.030748924,0.051367465,-0.029543107,-0.014377658,-0.030635532,0.01817062,0.004598654,0.024005316,0.0049432805,0.0040045623,-0.025003677,0.03586843,-0.061665494,0.07767121,-0.002634982,-0.10855647,-0.034419484,-0.04132187,-0.021449795,-0.053963292,0.058112852,0.002740639,-0.045448102,0.0063986606,-0.06776737,0.061440136,0.03541591,0.023777848,0.08512765,0.048423767,-0.024969043,0.06765369,-0.050296754,0.067554966,0.02532024,-0.0014836654,-0.05090578,-0.008883265,-0.07645724,-0.05743536,0.025233941,0.013815054,-0.021189751,-0.0104850605,-0.013478761,0.018099561,-0.024771795,-0.048207175,-0.114914246,-0.0254176,0.018596342,0.014751947,0.06833244,-0.0031445203,0.001346658,-0.044024188,0.0033087449,-0.02154747,-0.011625926,-0.018472224,0.054106038,0.08257015,0.0059516155,-0.1299897,0.10004439,-0.07007859,-0.013911042,0.0050511532,0.0149930725,-0.0122365225,0.08648806,-0.14280026,1.1601745e-33,0.123134084,0.01616118,0.05361562,-0.07913103,-0.025008857,-0.04411759,-0.050337482,0.01412914,-0.03370879,-0.056220617,-0.059754733,-0.06865937,0.008383214,-0.015326728,-0.007194241,0.021339592,-0.053300068,0.03258519,0.017026197,0.004868905,-0.06462804,0.012327643,-0.01905368,-0.06327321,0.034399852,0.026704304,0.012897256,-0.03153275,-0.028984167,-0.00077295443,0.09466792,-0.09642048,-0.12007767,0.04579283,0.13495424,-0.0058387783,-0.009034631,-0.026895141,-0.01834693,0.027129447,-0.046964817,0.062556654,0.037711397,0.0032459437,0.027164161,-0.020968975,-0.045867275,0.09211938,0.03900813,0.06517287,-0.03568121,-0.012652869,0.07132777,-0.017910345,-0.011031827,-0.02958268,0.014312298,0.016845088,0.003154783,0.0004091409,0.03579222,0.044870023,-0.07905116,-0.033796947,0.05636474,0.07166189,-0.024296843,0.05565058,0.022828927,0.032644838,-0.06066331,-0.07223315,-0.019470055,0.07090165,0.036945608,-0.030262005,-0.026062299,-0.002204743,0.012109821,0.030730639,-0.042406786,-0.06855791,-0.0038989258,-0.09200474,-0.107197665,0.024448235,0.010689955,-0.0024143988,-0.071096554,0.018730402,0.010029817,-0.032258693,-0.0031681375,0.009040636,-0.0059305755,-2.7808596e-33,0.015003369,-0.05452655,0.023027115,-0.11637855,-0.093934,0.03149038,-0.06955213,-0.008205699,-0.0065954006,0.06255354,0.014117333,0.06334124,0.03594257,-0.046110697,-0.017452555,0.013863838,0.04405759,-0.027869068,0.029875813,-0.029873336,-0.008636987,0.10606709,0.046726547,0.022122815,0.023141013,0.018018931,0.0035001736,0.02622125,0.063791856,0.01568855,0.013999732,0.00057380646,-0.001937919,0.0029858793,-0.07605887,0.007589528,-0.046934437,-0.022978526,0.04898236,0.031662956,0.044483267,-0.03377986,0.060680397,0.07631676,0.018495454,0.0053169583,-0.09346859,0.07669296,-0.007932083,-0.0059235473,-0.02240669,0.027454212,0.015097388,0.04584151,0.018141516,0.023740614,-0.0030809965,0.03453002,-0.058558963,-0.029093096,0.03317917,-0.055878572,-0.00011734147,0.027557913,0.023823801,0.061577402,0.014241196,-0.011455841,0.0041630627,-0.023307366,0.04750189,0.0108008385,0.0051804595,0.0019943805,-0.059286524,-0.018024353,-0.05478696,0.017430909,-0.027145715,0.017571095,0.03176348,0.034560975,0.0026827103,-0.080313444,0.06640434,-0.10730782,0.014470957,0.045994163,-0.025761962,0.012708649,0.0050877533,-0.0109651815,-0.057757158,0.044751782,0.04352304,-3.234832e-08,0.035897054,-0.01923053,0.087022826,-0.020596482,0.00695203,-0.019256637,0.04693385,0.093760826,0.06628972,0.045912772,-0.0037790635,0.09116307,0.032803293,-0.01146838,0.09288415,0.028900972,0.016244136,-0.019734358,-0.014771229,0.0028765146,-0.021691596,-0.10516877,-0.10397288,0.040435523,0.02400715,-0.061237276,0.11301135,-0.0095522385,-0.06994482,-0.014365158,0.053652797,0.033525847,-0.020851094,-0.041746866,-0.04165446,0.03375187,-0.09469202,-0.07120259,-0.03269431,0.05770823,-0.025293592,0.05529502,-0.09381548,0.03377349,0.0580351,0.07190426,0.06753908,0.042631783,-0.06782231,0.030712964,0.062613115,-0.032731947,0.027466508,-0.051476676,-0.15002768,0.031094102,0.08546457,-0.02689769,0.00089231535,0.04779797,-0.0015588738,-0.030498687,0.14564575,-0.013327105 +4.2.1.153,The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.,384,1.0,-0.053242575,-0.060322918,-0.068384565,-0.04093896,0.052273616,0.033516582,-0.01462609,-0.04123601,0.025288157,-0.013940716,0.01787962,-0.15106085,0.017638685,-0.004891532,-0.03194453,-0.016503202,-0.08814292,-0.020847205,0.003036615,-0.0395703,0.065764844,0.011132333,-0.07774432,0.024461478,0.04468589,0.010335686,-0.028843014,-0.08297934,-0.003485016,-0.028059546,0.0005597545,0.05786665,0.03930747,-0.03126557,0.097287595,0.070982724,-0.024224516,-0.106087506,0.052346576,0.04551179,-0.016956307,0.029780246,-0.011653648,-0.021337966,-0.035529684,0.030998886,0.04417149,0.045212954,0.091294475,-0.055409484,-0.026630184,-0.079628944,-0.10599327,-0.008858817,-0.035793714,0.037523635,0.015871163,-0.0012029229,0.061234627,-0.0024766019,-0.015000936,0.030030034,0.033542626,0.07357997,0.066892944,-0.064827725,0.00012283107,-0.050444964,-0.035002314,-0.03460194,-0.08374928,-0.023983996,-0.024759319,-0.007469071,0.027541837,0.031187888,0.04024774,-0.05731116,0.012464188,-0.058982633,0.0028241118,0.014227097,-0.02416905,0.07229661,-0.014143701,-0.03402497,0.012227487,-0.079567716,0.036009174,0.039758805,-0.018247945,0.0208406,0.004202773,-0.02560111,-0.069052316,0.08996492,0.052214064,0.04299173,0.12448819,-0.042541437,-0.015192832,-0.04421283,0.021026408,-0.11488384,-0.07151671,-0.016041655,-0.03511695,0.10897782,0.042381573,-0.0014923854,-0.08199218,0.06993874,0.010377652,0.010714597,0.051032823,0.11145102,0.09800468,-0.06513765,-0.043243267,0.01382444,-0.008576281,-0.063728586,0.056873616,0.04072175,-0.04180935,0.08631608,-0.0069529493,1.2547365e-33,0.002622366,-0.047439877,0.026795981,-0.051509053,-0.014266966,-0.009384036,-0.106337026,-0.07318177,-0.092112735,-0.11754073,-0.048756577,-0.005077816,-0.0071200477,-0.004564555,-0.018151546,-0.051146,-0.057469245,0.014146405,0.03524347,0.045395263,-0.006617267,0.0105283335,-0.047616284,0.02752505,0.014421176,-0.011638446,0.048989158,0.015163645,0.049316447,-0.012044679,0.053171884,-0.02805192,-0.093632415,-0.008505336,0.07020065,-0.009518561,0.05020792,-0.022723688,-0.059941456,0.04969451,0.014611666,0.046370734,0.0144492155,-0.101128675,0.07523494,-0.038578082,-0.045923166,0.051349685,0.0801037,0.057952467,-0.048949886,0.02355227,0.13414863,-0.052715853,-0.038050767,0.06619868,0.034237828,-0.03426741,-0.012870102,0.002428171,-0.00890413,0.09716707,-0.04091528,0.012726228,0.011856358,0.085891515,-0.022511888,-0.0020085324,0.07271421,0.020040656,-0.12066567,-0.0294416,0.015764922,0.06424677,0.059774876,-0.06272378,-0.043700974,0.001867235,-0.004911221,-0.040960994,-0.037758205,0.022540778,0.04802642,0.020655632,-0.044224925,-0.010815409,-0.022553278,0.0032651762,-0.03164797,0.03764797,0.124193564,-0.07826199,-0.0231303,-0.009322885,-0.057266254,-2.6311141e-33,0.101168565,-0.09867864,0.041397743,-0.035737872,-0.009531925,-0.0052998653,-0.0028631496,0.015074765,-0.028123993,-0.009080004,0.103297345,0.051128387,-0.027834052,-0.006041846,0.013896944,-0.010009881,0.03758368,0.07960796,-0.022745201,0.027947173,0.035548393,-0.034301728,0.07194774,-0.017610546,0.011522024,0.018554315,-0.015762078,0.06364741,0.08915236,-0.008642485,-0.08261827,0.045109764,-0.013337214,-0.012361096,-0.06218185,0.01845499,-0.04737983,0.016996833,0.019389395,0.023126103,-0.062849246,-0.0030145552,-0.041974,-0.033347804,0.030855263,0.12072591,-0.0175353,-0.003730261,-0.018483993,0.041181985,0.028139025,0.0030425715,0.046933983,0.037163,0.037115276,0.0012148763,0.08180655,0.08596558,0.05100767,-0.0962465,-0.06491704,0.0095275715,0.032010905,-0.05735138,0.032543074,0.05215638,-0.048400495,0.053877294,0.029065723,-0.03840808,0.070214786,-0.019717952,-0.0055199284,-0.020168932,-0.050951425,-0.039603937,-0.047613047,-0.050873853,-0.019353626,0.005893585,-0.014836208,0.06061477,-0.004080348,-0.027055066,-0.013601584,-0.11347629,-0.016382694,0.016247688,0.01071541,0.07588301,-0.042598173,-0.011019853,-0.049001362,0.023875752,0.10311691,-2.8479361e-08,-0.041053843,0.024923908,0.08632603,0.009805324,0.032395177,0.020708568,0.044519242,0.0016325142,0.0895269,-0.020318128,0.020924473,0.05767371,0.10511963,-0.060345907,-0.027474811,0.02114208,-0.05901759,-0.044623755,0.017860059,0.02769244,-0.06813061,-0.016798465,-0.11593445,0.05947466,0.060071513,-0.05460853,0.048060976,0.058768257,-0.0060315924,-0.02631072,-0.07481303,0.051753577,-0.0015981132,-0.04677502,-0.071033336,0.0069472836,-0.13494413,-0.011024554,-0.0333717,0.034056686,0.028445875,0.046875637,-0.053056546,-0.02142428,0.072878696,0.033698756,-0.04813619,0.032164387,0.036557242,-0.03533793,0.049460843,-0.043393444,-0.039290074,-0.008347945,-0.06581854,0.024441078,-0.013151931,-0.11600681,-0.021906275,-0.0077425726,-0.04095369,0.053818554,0.12829472,-0.050588623 +4.2.1.154,The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens.,384,1.0,-0.036142554,0.038560607,-0.19773322,0.0069456864,0.017356152,0.010842825,-0.069723584,0.0420456,0.059147898,-0.028586168,-0.031467214,-0.045581423,0.027476395,0.026639782,-0.078159526,-0.0258469,-0.08937887,-0.0034617274,0.037141588,-0.100089505,0.031091098,0.06926602,0.051215608,-0.013623889,0.032998163,-0.017198823,-0.031999037,0.011326188,-0.04699763,-0.0012453045,0.03483651,-0.031647053,0.029722866,-0.079163454,0.059606254,0.08502329,-0.103333525,0.010912326,0.14426933,0.034539163,-0.039079875,0.018001094,-0.036917437,0.058555264,-0.08650144,0.0943246,0.040439393,0.044735294,0.0031133676,0.020129804,-0.033301465,-0.013897964,-0.12506393,0.04701788,0.03153882,-0.009836116,-0.018496877,0.0002331535,0.03401711,-0.011996553,0.10920336,-0.039951693,0.025532516,0.047519695,-0.1015266,-0.046078686,0.010141738,-0.046629712,0.035436396,-0.033074725,-0.0765225,-0.006110262,-0.03026444,0.022762038,-0.022619097,0.039559465,-0.0013000163,0.006902308,-0.03399075,0.03255284,0.062243596,-0.055550743,-0.023484156,0.12265568,0.06341723,-0.017261421,0.022513468,0.055532217,0.06979526,0.05584771,0.0651288,-0.0065636383,-0.029514309,-0.026581075,-0.06977601,-0.03257691,-0.0010235353,0.018508209,-0.026235601,-0.04614502,-0.0757077,-0.005500501,0.021737339,0.0062319087,-0.02789335,-0.013706737,-0.031351876,0.09682425,0.03775092,-0.046317246,-0.04850965,0.05989171,-0.0035141513,-0.034622133,-0.03923571,0.083156295,0.07082435,-0.049484964,0.0068045165,0.026473844,0.03365127,0.02451006,0.006047763,0.05125863,0.013545335,-0.001745137,-0.0711424,4.445128e-33,-0.025284236,0.103136584,0.003382157,-0.08171725,0.035821997,-0.013090742,-0.054783206,-0.018523451,-0.033980004,-0.016549703,-0.03932895,-0.11020336,0.047427304,0.055988215,0.0038161576,0.021316193,0.013690474,-0.0057328977,0.003975661,-0.009180492,0.00793022,0.04842462,-0.053578075,0.038653545,0.023662405,0.071364984,-0.017245749,0.084165946,0.08967601,-0.032427892,-0.006162712,-0.06292768,-0.047712307,0.003785083,0.1259903,-0.02700218,-0.07317257,-0.040027626,0.053312168,0.04330413,-0.022017423,0.012200098,0.03472542,-0.0008589885,0.037244383,0.0075351447,-0.06434468,0.113561064,0.06278088,0.047445677,0.07718253,-0.039446782,0.107907906,0.021453775,-0.059526537,0.03433383,-0.027726077,0.041716114,-0.008548752,0.024020344,0.005193172,-0.03903247,0.007950855,0.06465387,-0.002087301,-0.009932359,-0.06583791,-0.04120222,0.007866222,0.03213984,-0.077143304,0.02766126,0.045176093,-0.0018327556,-0.011779153,0.06482434,-0.09948126,-0.06740491,0.06294359,-0.002689202,-0.08996072,-0.03956782,-0.0042322273,-0.05359704,-0.04233155,0.009206574,-0.06852984,-0.055550843,0.050930668,0.06846034,-0.015930895,-0.103013605,-0.11055277,0.03761089,0.012611449,-5.7339222e-33,0.07348878,-0.033221364,0.06557113,-0.042418372,-0.06857783,0.06468735,-0.0313345,-0.057137225,-0.0105965305,0.0028077865,0.042202163,-0.028004741,-0.04162388,-0.024766542,-0.029633053,-0.07113912,0.07333505,0.09485509,0.015330547,0.056145813,0.03910282,0.05191964,-0.04186842,-0.11096333,0.0025238867,0.0018244834,-0.010246813,0.058534823,0.044342734,0.027058689,-0.010570743,-0.037761223,-0.020357028,-0.030296702,-0.007458412,0.119013704,-0.019038921,-0.014774172,0.11099329,-0.003568272,0.101332836,0.0034692318,-0.027884344,0.09420958,0.03194996,0.0705436,-0.060663342,0.08360292,-0.012895466,-0.049044386,-0.0068397895,0.026157876,0.032812946,-0.0024806475,0.010923413,-0.0064418605,0.022065226,-0.060457185,-0.017289585,-0.07134401,-0.018484872,-0.068220384,0.01670307,-0.01615396,0.018370511,0.034649126,-0.046878055,0.06506437,0.10910488,-0.01414431,0.047736034,-0.017016815,-0.088911384,0.020589415,-0.06274141,-0.048202474,-0.053793374,-0.05769101,0.01491987,0.021537349,0.0029139793,0.029707443,0.051629942,-0.03406168,-0.010175957,-0.010139588,0.024132656,0.070587344,0.017077973,0.03587247,-0.020060496,0.0581469,0.017495781,0.04511943,0.051786378,-3.013476e-08,0.035202235,-0.028328562,0.059931226,-0.04490067,0.0012647689,-0.041331187,0.0111589655,-0.0022145694,-0.019335095,0.0076254345,-0.05071053,0.004588742,0.020535069,-0.019980617,-0.028890666,0.03468877,-0.067830145,-0.06261409,0.022292124,-0.051488426,-0.07468361,-0.031318948,-0.09068924,0.04163637,0.0038438055,-0.0724075,0.011178589,-0.009033973,-0.04106534,0.008759841,0.023915818,-0.02159302,0.0062402934,-0.017889265,-0.07755252,0.0044712196,-0.08212947,-0.061447788,0.0850014,-0.03943714,0.031906914,0.04566843,-0.07630643,0.052097913,-0.056283712,0.019073429,-0.037843797,-0.033885375,-0.038396396,-0.04407219,0.076657645,0.013211891,-0.04744251,-0.020570012,-0.053062312,0.0015313999,-0.019497743,0.002261496,-0.0593724,-0.057783652,-0.03468301,0.010433252,0.17273617,-0.09208561 +4.2.3.145,Isolated from the fungus Aspergillus clavatus. The product is a sesterterpenoid (C25 terpenoid).,384,0.99999994,-0.002280434,0.03476887,-0.11993656,0.0044304463,0.021026887,0.0077727875,-0.06605986,0.064128764,0.0188462,-0.07637125,0.10158985,-0.06320458,-0.019028742,-0.015297386,-0.11095944,0.025528166,0.107746795,0.0073885657,0.014938176,-0.01653989,0.022474784,0.11382787,0.03890335,0.017503327,0.01921264,0.03549046,0.048790704,0.014354279,0.00937086,-0.12088536,-0.078616954,-0.014947376,-0.007400797,-0.049385574,0.049098153,0.024340842,-0.09100086,0.0595506,0.106849425,0.089414686,0.0021414594,-0.067164764,0.0018792049,-0.08128373,-0.0525221,-0.026462557,-0.077017106,0.04713476,0.059342206,0.007132446,0.0067822095,-0.015210436,-0.015598489,0.045699786,0.044051915,-0.030317936,0.030267432,-0.07400812,-0.047220275,0.035837356,0.050482407,0.014059702,-0.03111149,-0.008353652,-0.085719205,0.012505292,0.0022865008,-0.0032137749,-0.0063737477,-0.05873447,-0.0010643406,-0.043094862,0.039818637,0.02414133,-0.031631675,0.013955663,0.021943,-0.035506777,0.069767766,0.008341771,0.048024718,0.053719368,0.020342628,0.03127683,0.021879414,0.008775097,-0.0009744718,0.06467527,0.020213125,0.021636318,-0.006348425,0.11211717,0.0058054933,-0.014582028,-0.053316202,0.06693065,0.050456762,0.0738372,0.012371245,0.0056475657,0.04999182,-0.047335993,0.054803994,-0.05965034,-0.028347306,0.02427359,-0.0060106236,-0.049935438,0.07468746,-0.07879716,-0.012267046,-0.020252183,-0.06707684,-0.09988129,0.04886524,-0.041279163,0.087051764,-0.0012046042,0.057369642,-0.031371094,0.030122418,0.04245175,0.033727974,-0.04979539,0.025522279,0.046349034,-0.017972417,9.620953e-35,0.027205242,0.01448945,-0.014672003,0.021185473,-0.01251258,0.021444606,0.006837979,0.026352689,-0.10441881,-0.049439564,-0.079247035,-0.06508358,-0.067147866,0.03334403,0.048159678,-0.024690257,0.06521894,-0.01199968,0.047643617,-0.07578085,0.0432412,0.07557553,-0.07048672,0.011679019,-0.0040804553,-0.018420113,0.010796044,-0.038562004,0.056226134,-0.025605138,0.04667468,0.005066155,-0.04235252,-0.0679783,0.08145737,0.0006708726,-0.029495604,0.02532344,-0.09549373,0.048184104,0.028769087,0.007943631,0.01719151,-0.049758155,0.01063273,-0.030850476,-0.07910045,0.018535214,0.11451505,-0.025525063,0.017666392,0.040931247,0.034950454,0.023226712,-0.024081914,-0.028511453,-0.037133697,0.05597538,-0.0013121128,0.06672278,-0.026781354,0.08976572,-0.04587564,0.025279062,0.0187729,-0.0021685036,-0.11260456,-0.019312259,-0.037396993,-0.055448603,0.013750396,0.0037874053,0.07896883,-0.081338294,0.0687187,-0.015460933,-0.058072772,-0.015803846,-0.028910063,-0.068948194,-0.07503156,-0.032569744,0.042103536,-0.033674207,-0.14384891,0.03622848,-0.009037794,0.032109745,7.526012e-05,0.050213695,-0.025340501,-0.03587175,-0.09172216,0.028577574,-0.0028849186,-1.7891063e-33,0.10348008,-0.087371334,0.04723475,-0.023802873,-0.014685276,0.12285716,-0.03127996,0.020916797,-0.092762515,0.011979695,0.020870036,0.026850808,0.10057519,0.011265014,0.022009104,0.06390196,0.0013952303,0.14364202,0.018699184,-0.022867896,0.00588226,0.030164717,-0.0069373013,0.056527782,0.025905572,0.008033304,0.06512517,-0.056252122,-0.030000659,0.043752402,-0.013238656,0.01197562,-0.006155313,0.01169908,-0.100243315,0.08065002,-0.028829249,-0.07828327,-0.044687442,0.03495771,-0.06456861,-0.0019545967,-0.03887926,0.08552967,0.059675593,0.0056558214,-0.033305198,0.038723502,0.033417676,-0.0012398807,0.04098417,-0.0075024143,0.016898224,-0.074340165,-0.009856641,-0.012109956,-0.02729775,-0.028597407,0.073670104,-0.030285751,0.0003482943,-0.005519746,-0.088574775,-0.010446731,0.10274785,0.052036885,-0.043626375,-0.0054450096,0.02090296,-0.06496212,0.020182326,0.069031,-0.026727336,0.004467559,0.050717212,0.009840653,0.0370771,-0.06036264,-0.021025402,0.036630798,0.014644059,-0.09331574,0.05973521,-0.008661919,-0.088737935,-0.0919615,0.09342227,-0.029922107,-0.03854861,0.027623894,-0.031530358,0.07522071,-0.13610192,0.05904053,0.08773653,-2.2575525e-08,0.10040086,0.0074052685,0.0005475707,-0.043027926,-0.0079532135,-0.021853834,0.05212227,-0.05474025,0.07217014,0.06364286,-0.105731145,0.02255761,0.019600233,0.07601021,0.084042594,-0.01405244,0.0068499404,-0.026102392,0.022821967,-0.009013426,-0.02004174,-0.027494991,0.0005537241,-0.017995575,-0.061976414,-0.08251743,0.021444865,0.0064978455,0.073800415,-0.013210866,0.0017291711,0.04920377,-0.035754733,-0.052037597,0.035871666,0.0802558,-0.038530458,-0.011576788,-0.029764984,0.07407641,-0.022380464,-0.09441649,-0.03873008,-0.009726267,-0.075752065,-0.062156055,-0.029335722,0.010120363,-0.03254085,-0.0570481,0.02095765,-0.018339712,0.010696483,-0.009556544,-0.030535245,-0.050687246,0.039952777,-0.037989005,-0.03455028,-0.065384164,-0.084187225,-0.004364886,0.104121596,0.069134995 +4.2.3.146,"Requires Mg2+. Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase.",384,0.99999994,-0.07810077,-0.07056563,-0.075040154,0.040695064,0.041118536,0.012589398,-0.042459566,0.048376426,-0.008956196,-0.03783403,-0.0063797133,-0.044517238,0.015316423,0.025681935,-0.04281053,0.015783783,-0.0012398725,0.037510466,0.049366333,-0.01425936,0.10977188,0.09067397,0.038863532,0.002437179,0.04352751,0.050690524,-0.008150623,-0.01050452,0.04944583,0.0087436335,0.009437686,0.005927653,0.065195434,-0.11466004,0.098960884,0.11829251,-0.053502463,0.013155433,0.062696494,-0.06806939,-0.0010711504,-0.050253537,0.064753465,-0.0028066253,-0.014907743,-0.027532123,0.08202336,0.033112045,0.027421921,0.01862368,-0.05401865,-0.036508746,-0.10236243,0.03608527,0.00806371,-0.030230464,-0.11341369,0.03478752,0.03767585,-0.03231798,0.020427007,0.025606649,-0.040501833,0.012783159,-0.020422464,-0.0031490442,-0.010692951,-0.1082197,0.0870387,0.041082308,-0.05322835,0.004824569,-0.012266622,0.051009133,-0.028693562,0.12643048,0.06371012,-0.07084985,-0.021570332,-0.026581258,0.11754159,-0.008597475,0.078638524,0.11680274,0.028017802,-0.048591096,0.02234067,0.06931281,0.0022223366,0.028557159,0.08161676,0.038222477,0.035752688,-0.007394412,-0.045172505,0.009923804,-0.13655393,0.0027142237,-0.038810402,0.0503129,0.0036570765,0.013826385,0.028438965,-0.015582158,-0.002379278,0.013961921,-0.06382606,0.0126874605,0.037762225,0.002178821,0.06488128,-0.0063625453,-0.030101802,0.014222317,0.023798529,0.057968725,0.07681784,-0.10607406,-0.06006395,-0.004648194,0.02684676,-0.015755704,0.023223044,0.009317674,-0.06821943,0.020734387,-0.11104064,3.6575356e-33,0.0068399156,0.022545656,0.079596676,-0.031121545,0.015392539,7.552401e-05,-0.045774106,-0.06691128,0.033776037,-0.03951795,-0.068621814,-0.03763876,0.01891733,0.055482812,-0.015481019,-0.007214378,0.0062864316,0.02463928,0.10447655,-0.014795647,-0.0004975049,0.04869663,-0.027783647,-0.040361956,0.040235367,0.08850956,0.0033137335,-0.025982507,0.08508123,0.017650083,-0.0077378172,-0.123731405,-0.07315312,0.023180641,0.06398997,-0.05388243,-0.07736646,-0.13784723,0.02852904,0.006362385,-0.10660579,0.023908058,-0.045396887,0.013396256,0.0813174,-0.06370053,-0.05223182,0.058847938,-0.042048328,0.052789256,0.08457526,-0.042072155,0.008883141,0.040143143,-0.08597478,0.02185749,-0.02552228,0.047544792,0.071829155,0.029734157,0.018484602,0.042522274,0.023108257,0.04433681,0.073037006,0.017631967,-0.055997286,-0.057325453,-0.11540517,0.016123598,-0.013196391,-0.084754,0.018401455,0.02597079,-0.034079295,-0.05161115,-0.0029537296,0.0127046555,0.008503003,0.035378333,-0.01446762,-0.047614917,-0.05040596,-0.04517598,-0.09637713,0.063139595,-0.0046006567,-0.036203515,-0.0074060517,-0.00043607914,-0.044260062,-0.083627984,-0.049836446,0.08700663,-0.07309994,-4.5478675e-33,0.04947601,0.0017953304,0.084840134,-0.032406095,-0.085124165,0.039559286,0.011651037,-0.11259565,0.021744614,0.012818279,0.024779007,-0.0011884959,0.06132185,-0.04068654,0.016469136,-0.052628323,0.031568952,0.08829742,-0.026981052,0.023223963,0.027737224,0.0731777,0.030104274,0.044537526,0.030134957,-0.014590534,-0.0052589984,0.023470115,-0.015479244,0.07691237,-0.06796614,0.054827888,-0.064157,-0.15289089,-0.06261174,0.04572755,-0.008501944,-0.038571995,0.026855683,0.021416489,0.029724821,0.054166254,0.031583518,0.073940605,0.022139825,0.046766847,-0.042124264,0.04672265,0.02357372,-0.029459452,-0.02953607,0.017057458,-0.048839316,0.023606224,0.009470951,0.035918333,0.01083014,0.05311768,-0.0075379484,-0.02570866,-0.034422204,-0.041381016,-0.008458175,-0.049378283,0.13536632,0.112252206,0.043723844,0.06031598,0.022802971,0.03778113,0.061069768,0.011886831,0.042562015,0.030233005,-0.017736485,0.10538077,-0.03766229,-0.055716056,0.012436913,-0.05617951,0.058985736,0.0050508655,0.058796458,-0.019196397,-0.00283546,-0.11108987,0.045009673,0.056645874,0.010188642,0.008687532,-0.031269114,-0.027089316,-0.0049940767,0.050588883,-0.0016552104,-3.2502438e-08,0.021926226,-0.039561495,0.022139374,-0.098751456,-0.010895844,-0.0019938909,-0.05149498,-0.03581671,0.005572692,-0.004701386,-0.021972023,-0.04275105,0.009782094,-0.02414942,-0.015001512,0.039661527,-0.0038048036,0.010947411,-0.049065616,-0.058605187,-0.04299932,-0.062884256,-0.05575598,0.05864601,0.040859684,-0.104917414,0.043019537,0.0122369835,-0.027391136,0.035362665,-0.0006443099,-0.007984638,-0.0556918,-0.0013803821,-0.07239244,0.0053825458,-0.098808,-0.03790101,-0.03815071,-0.050484415,-0.062609695,0.016530901,0.04312182,0.009311258,-0.076952375,0.02378439,0.0014851113,0.04903925,-0.046606235,0.03617999,0.02503992,-0.022793304,-0.035546474,-0.057918053,-0.041722275,-0.0105124675,0.044875707,-0.03437027,-0.034527674,-0.07225068,-0.03712681,0.014242205,0.11630439,-0.061649226 +5.1.3.29,"This enzyme shows no 1-epimerase activity with D-glucose, L-rhamnose and D-fucose (cf. EC 5.1.3.3, aldose 1-epimerase) [1]. 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+5.3.1.31,"The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea.",384,1.0,-0.081105225,-0.048594564,-0.10848376,0.008835624,0.046745438,0.032828197,-0.049831737,0.032870505,0.07586287,-0.02913979,0.05445136,0.009486292,-0.059808504,0.07226813,-0.03937746,0.070400394,-0.1304683,0.029386794,-0.024048015,-0.028893366,0.05958483,0.045026932,-0.09444737,-0.0056915265,0.019239303,0.0630403,-0.059983052,-0.049416408,-0.09797374,-0.008290234,0.027908891,0.012696363,0.057618678,-0.035901356,0.07355347,0.1522308,0.028199598,-0.10104334,0.0683804,-0.004423828,-0.018378016,0.0072768857,-0.054817714,-0.0065369243,-0.035815757,0.026034571,0.010792563,0.058089305,0.060984876,-0.13011214,-0.068549275,-0.03453788,-0.06960186,0.019426117,0.028898627,0.030748924,0.051367465,-0.029543107,-0.014377658,-0.030635532,0.01817062,0.004598654,0.024005316,0.0049432805,0.0040045623,-0.025003677,0.03586843,-0.061665494,0.07767121,-0.002634982,-0.10855647,-0.034419484,-0.04132187,-0.021449795,-0.053963292,0.058112852,0.002740639,-0.045448102,0.0063986606,-0.06776737,0.061440136,0.03541591,0.023777848,0.08512765,0.048423767,-0.024969043,0.06765369,-0.050296754,0.067554966,0.02532024,-0.0014836654,-0.05090578,-0.008883265,-0.07645724,-0.05743536,0.025233941,0.013815054,-0.021189751,-0.0104850605,-0.013478761,0.018099561,-0.024771795,-0.048207175,-0.114914246,-0.0254176,0.018596342,0.014751947,0.06833244,-0.0031445203,0.001346658,-0.044024188,0.0033087449,-0.02154747,-0.011625926,-0.018472224,0.054106038,0.08257015,0.0059516155,-0.1299897,0.10004439,-0.07007859,-0.013911042,0.0050511532,0.0149930725,-0.0122365225,0.08648806,-0.14280026,1.1601745e-33,0.123134084,0.01616118,0.05361562,-0.07913103,-0.025008857,-0.04411759,-0.050337482,0.01412914,-0.03370879,-0.056220617,-0.059754733,-0.06865937,0.008383214,-0.015326728,-0.007194241,0.021339592,-0.053300068,0.03258519,0.017026197,0.004868905,-0.06462804,0.012327643,-0.01905368,-0.06327321,0.034399852,0.026704304,0.012897256,-0.03153275,-0.028984167,-0.00077295443,0.09466792,-0.09642048,-0.12007767,0.04579283,0.13495424,-0.0058387783,-0.009034631,-0.026895141,-0.01834693,0.027129447,-0.046964817,0.062556654,0.037711397,0.0032459437,0.027164161,-0.020968975,-0.045867275,0.09211938,0.03900813,0.06517287,-0.03568121,-0.012652869,0.07132777,-0.017910345,-0.011031827,-0.02958268,0.014312298,0.016845088,0.003154783,0.0004091409,0.03579222,0.044870023,-0.07905116,-0.033796947,0.05636474,0.07166189,-0.024296843,0.05565058,0.022828927,0.032644838,-0.06066331,-0.07223315,-0.019470055,0.07090165,0.036945608,-0.030262005,-0.026062299,-0.002204743,0.012109821,0.030730639,-0.042406786,-0.06855791,-0.0038989258,-0.09200474,-0.107197665,0.024448235,0.010689955,-0.0024143988,-0.071096554,0.018730402,0.010029817,-0.032258693,-0.0031681375,0.009040636,-0.0059305755,-2.7808596e-33,0.015003369,-0.05452655,0.023027115,-0.11637855,-0.093934,0.03149038,-0.06955213,-0.008205699,-0.0065954006,0.06255354,0.014117333,0.06334124,0.03594257,-0.046110697,-0.017452555,0.013863838,0.04405759,-0.027869068,0.029875813,-0.029873336,-0.008636987,0.10606709,0.046726547,0.022122815,0.023141013,0.018018931,0.0035001736,0.02622125,0.063791856,0.01568855,0.013999732,0.00057380646,-0.001937919,0.0029858793,-0.07605887,0.007589528,-0.046934437,-0.022978526,0.04898236,0.031662956,0.044483267,-0.03377986,0.060680397,0.07631676,0.018495454,0.0053169583,-0.09346859,0.07669296,-0.007932083,-0.0059235473,-0.02240669,0.027454212,0.015097388,0.04584151,0.018141516,0.023740614,-0.0030809965,0.03453002,-0.058558963,-0.029093096,0.03317917,-0.055878572,-0.00011734147,0.027557913,0.023823801,0.061577402,0.014241196,-0.011455841,0.0041630627,-0.023307366,0.04750189,0.0108008385,0.0051804595,0.0019943805,-0.059286524,-0.018024353,-0.05478696,0.017430909,-0.027145715,0.017571095,0.03176348,0.034560975,0.0026827103,-0.080313444,0.06640434,-0.10730782,0.014470957,0.045994163,-0.025761962,0.012708649,0.0050877533,-0.0109651815,-0.057757158,0.044751782,0.04352304,-3.234832e-08,0.035897054,-0.01923053,0.087022826,-0.020596482,0.00695203,-0.019256637,0.04693385,0.093760826,0.06628972,0.045912772,-0.0037790635,0.09116307,0.032803293,-0.01146838,0.09288415,0.028900972,0.016244136,-0.019734358,-0.014771229,0.0028765146,-0.021691596,-0.10516877,-0.10397288,0.040435523,0.02400715,-0.061237276,0.11301135,-0.0095522385,-0.06994482,-0.014365158,0.053652797,0.033525847,-0.020851094,-0.041746866,-0.04165446,0.03375187,-0.09469202,-0.07120259,-0.03269431,0.05770823,-0.025293592,0.05529502,-0.09381548,0.03377349,0.0580351,0.07190426,0.06753908,0.042631783,-0.06782231,0.030712964,0.062613115,-0.032731947,0.027466508,-0.051476676,-0.15002768,0.031094102,0.08546457,-0.02689769,0.00089231535,0.04779797,-0.0015588738,-0.030498687,0.14564575,-0.013327105 +5.4.4.7,"Binds Fe2+. The enzyme from mammals accepts a range of hydroperoxyicosatetraenoates producing one or several different hydroxyepoxyicosatrienoates. The human enzyme has highest activity with (12R)-HPETE producing (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate, followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate [1]. The mouse enzyme has highest activity with (8S)-HPETE, producing (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate [2]. The enzymes also have the activity of EC 4.2.1.152, hydroperoxy icosatetraenoate dehydratase.",384,1.0,-0.031081755,-0.07657862,-0.08117637,-0.053286906,0.015637299,0.03141134,0.055565003,0.055471662,-0.015067406,-0.04629831,0.025624564,0.0065936763,-0.059615698,0.03873776,-0.050716285,0.013493473,-0.029271314,0.0015643827,-0.028102048,-0.03882005,0.077241965,-0.038949873,0.0183582,-0.018146465,-0.08029766,0.019918233,0.06970069,-0.045536965,-0.0071297092,-0.09460413,-0.020225346,-0.05108414,0.041956287,-0.023242202,-0.042201106,0.062063888,-0.03753006,-0.09620984,0.019738853,0.021067923,0.0058175977,-0.08036105,-0.03004765,-0.010932757,-0.05686256,-0.06589429,-0.022205068,-0.014580908,-0.006859106,0.071942806,-0.015083654,0.009628897,-0.07639519,0.06278692,0.0125750415,-0.039607707,0.0013741442,-0.025604183,-0.047321416,0.017266747,-0.010106256,-0.012002066,-0.015311157,0.026936904,0.0032104505,-0.026168896,0.053207956,-0.046593808,-0.0864202,-0.015138071,-0.039877206,-0.018169051,-0.015089023,-0.0052712457,-0.011200694,0.014588938,-0.0055592763,-0.036016252,0.07281914,-0.07296098,-0.0019758781,0.008845646,0.030422065,0.11055662,0.06304707,0.006593183,-0.1302197,0.046074763,0.011986244,0.11991716,0.0071527353,0.052345004,-0.04031994,0.033869147,0.0036330277,0.074224964,0.09011014,0.024674209,0.0009903664,-0.022404855,0.0046936492,0.05568506,-0.05302837,-0.10563212,0.006312811,0.057930924,-0.019502455,0.007403309,0.023114948,0.049789637,-0.0124607645,-0.0055157845,0.014041755,0.017470812,0.024117164,0.08628517,0.047627706,-0.028337715,0.030268053,-0.011215862,0.05547545,0.01798844,0.03869452,0.046242423,-0.010420057,0.058036108,-0.0666746,2.575361e-33,0.073597685,0.038265433,0.010333695,0.037833426,-0.005879933,0.110822745,-0.05925726,0.036313556,-0.04501744,0.007499341,-0.093134135,-0.026585761,0.040501587,0.013484447,0.021577334,-0.02061216,0.024871526,0.011623049,0.04816234,-0.03217055,0.018664056,0.0068417815,-0.03904404,-0.039880063,0.0032358149,0.08282602,-0.110283725,0.07356118,-0.029640557,-0.022738973,0.026567118,-0.114338204,-0.08371703,0.019929444,0.06810002,-0.037206165,0.025853414,-0.016320335,-0.05051107,-0.01889856,0.05479655,-0.007017248,0.0042297123,-0.08249254,0.0861084,-0.07726552,-0.072217636,0.09431718,-0.0044927164,0.06548708,0.003925176,-0.041285194,0.07844167,-0.029693404,-0.11639001,0.056063943,-0.006072263,0.029936746,0.04152806,0.1534628,-0.0043731155,0.11456425,0.0709447,0.0589338,0.07719189,0.020227646,-0.052672844,-0.027898304,-0.040373977,0.15611897,-0.012689693,0.012546404,0.106797114,-0.033729825,0.10384545,-0.044764414,-0.027611569,0.019400261,0.0033779119,0.04445185,0.0048714085,0.003279867,0.04757434,-0.0015567843,-0.11470752,0.009882891,-0.061114147,-0.021623878,-0.015707815,0.052835565,0.048417035,-0.050344072,-0.011757189,-0.06106575,-0.023527218,-3.5693394e-33,0.03414439,-0.044850554,0.08477659,-0.058694802,-0.041426,0.06270538,0.038079683,-0.055061653,-0.007259368,0.0007435893,0.12511072,0.022398125,0.043471437,-0.08317164,0.047932994,0.08519392,-0.05254184,0.11381751,0.048201837,-0.06988696,-0.0055585415,0.03781039,-0.037575167,0.13146698,0.07241365,-0.032624085,-0.024301294,0.004804867,0.068471946,0.045296047,0.018877123,-0.0020521341,-0.04301304,-0.028287994,0.019188406,-0.03714962,-0.0567532,-0.0069182506,0.040779937,0.03475649,0.033698156,-0.009005652,0.025355909,0.07037033,0.03040994,0.083527595,-0.08132741,-0.0012518538,-0.005018601,0.07474244,-0.0054008793,-0.016856989,-0.13834698,0.03456911,0.0628367,0.0150792375,0.043273695,-0.04819035,0.053569123,-0.03821638,-0.011820827,-0.0128661655,-0.049709138,0.07658851,0.044063248,-0.019450996,-0.064485714,0.05678605,-0.007087253,-0.0002310441,0.06865411,0.001555817,0.02235896,-0.041648246,-0.04116051,-0.0080025345,0.037659895,-0.05961946,-0.0029814444,-0.015818445,0.00033120485,0.021800186,-0.015536685,-0.07447946,-0.04480182,-0.03390957,-0.037774466,0.107764766,0.03247919,-0.006201477,-0.0122189475,0.0063694464,-0.092004195,-0.048169687,0.006520594,-5.8163664e-08,-0.018950615,-0.08442482,0.02148444,-0.07749055,0.0034375968,0.026509883,0.034743987,0.05756679,0.048360236,-0.046760425,0.007230997,0.04086346,0.0027827872,0.035697117,0.08768029,-0.020004585,-0.013369968,0.038406156,-0.016138691,0.0068795877,-0.04707701,-0.0009814596,-0.063193634,-0.0040120226,-0.0038777369,-0.09602358,-0.038431488,0.039684776,0.031370867,-0.012514674,-0.0072672237,-0.004803727,-0.062162865,-0.033254184,-0.06696554,0.02243654,-0.010114231,-0.023375941,-0.06591816,0.0656156,-0.07224284,-0.09450806,-0.08503292,-0.022151882,0.018258372,-0.02403484,-0.011698018,-0.0053314897,0.041876774,-0.026779328,-0.0124936225,-0.012374662,0.073297985,-0.10034844,-0.035152573,0.01772747,-0.031504214,-0.049004056,0.043825623,-0.07961225,0.04033502,0.026474986,0.13803805,0.0065486333 +6.1.2.2,Requires Fe(III). The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin.,384,1.0,-0.05466259,-0.06789695,-0.12138446,0.043550074,0.025533201,0.08824677,-0.018095497,0.011594483,0.037401125,-0.0672527,-0.007239178,-0.01358031,0.048037954,0.03824,-0.023224281,-0.061506018,-0.019895706,0.04060738,0.03997742,0.026345285,0.07422873,0.035131462,0.05728271,-0.0696144,-0.007982782,-0.0181913,0.037319664,-0.017118353,-0.05987594,-0.06498097,0.0057963836,-0.033962842,0.10321707,-0.08803713,0.066352434,0.051962234,-0.068500906,-0.08968625,0.097188726,0.0028606332,-0.058672022,-0.046238683,0.005563119,-0.038795955,-0.04538906,-0.024294866,0.11900045,0.047940057,0.022874808,-0.02623142,-0.07871126,-0.014530911,-0.01956704,0.0010026606,0.017691202,0.029560601,0.00052123563,-0.0064900005,3.0916188e-05,-0.051161543,0.025170324,0.016696792,0.029739756,0.011946764,-0.04844364,-0.020558165,0.019326689,-0.101741605,0.0007245716,0.062074408,-0.029474633,0.005715925,0.009525466,-0.0198605,-0.024426192,0.024139358,0.01884632,-0.0152264,0.056632742,-0.044167098,0.0006220138,-0.051988598,0.0018541985,0.0712485,-0.0057286466,0.01936341,-0.009502267,0.0053475583,0.035015795,0.09723292,0.065953195,-0.024215247,-0.021753194,-0.038846195,-0.058707926,-0.068894014,0.046227474,-0.027050857,0.04120177,-0.02285791,-0.039739527,0.044519477,0.020905847,-0.044619188,-0.021416834,0.036515713,-0.0341542,0.08378321,0.017799687,-0.008155464,0.032081563,-0.027538955,0.04773495,-0.027628897,-0.05089848,0.039247356,0.07861817,-0.07232913,-0.10593271,0.0365859,0.031177197,-0.018950455,0.013167912,0.059070293,-0.08324996,0.017963367,-0.10325935,5.200968e-33,0.058801897,0.07428102,0.015932241,0.00028883855,0.0069519407,-0.012721262,-0.089896955,-0.042673167,-0.0145686725,-0.06591753,-0.09739713,-0.08417433,0.02406606,-0.015670415,-0.045840744,0.0028563542,-0.103586994,0.0058253217,0.05030799,0.011536129,0.054245163,0.05872974,0.054678246,0.012660369,0.039893553,0.104041845,-0.019174665,0.0032998335,0.062216744,0.0067865807,0.07592842,-0.078782834,-0.084361,-0.046895895,0.12051115,-0.0017192439,-0.026963763,-0.023999847,0.018560259,-0.0051632165,0.005315794,0.029645223,-0.04222177,-0.030976398,0.08194018,-0.060645726,0.045406677,0.1728386,0.03875443,0.09487979,0.05114229,-0.05101707,0.05878225,-0.022001773,-0.10123815,0.022006288,-0.03752679,0.009458394,0.02434171,0.04752593,0.022077478,-0.016765451,0.079856925,0.028506512,0.0029684023,0.006713681,-0.052254423,0.017087478,0.04694951,0.026441101,-0.039512027,-0.017829996,0.04821935,0.026689831,0.010389507,0.025112566,-0.06188964,-0.05727337,0.08837393,-0.025466273,-0.0050443965,-0.032792043,0.010657097,-0.06627392,0.00058315194,0.033606436,-0.077691324,-0.05233685,-0.02628354,0.09379944,0.03181758,-0.061576378,-0.061297342,-0.0010078059,0.02459171,-6.691688e-33,0.07631606,-0.07203114,0.0903837,-0.03329083,-0.062295046,0.020667525,-0.013667667,-0.08383183,0.0007104544,-0.03886227,0.009066011,0.0014306967,0.053013105,-0.10392887,0.012291848,-0.0038715415,0.024684034,0.07311051,-0.041682195,-0.02584487,-0.0071842633,0.009555427,-0.017905695,-0.005727671,0.011944244,0.09200822,-0.061357524,0.041129228,0.07331414,0.10139448,0.057872564,-0.008688362,-0.053878997,-0.081371665,-0.040187955,0.0469806,-0.009909095,0.025289504,0.09773219,0.007871384,0.02721308,-0.00268527,0.00835843,-0.003052968,-0.0015512467,0.025321176,-0.042077772,0.025557492,-0.005326909,-0.008020097,0.0011988409,-0.054371875,-0.0632341,-0.04160715,-0.0023987314,0.05008444,0.0916929,0.030203335,-0.032490715,0.023898449,-0.044399746,-0.028984519,0.099761896,0.0068404847,0.000993331,0.028009444,0.024469193,0.10278659,0.10698996,-0.030805647,-0.0034255593,0.029653547,0.033232167,0.025919015,0.007823039,0.034859717,-0.06790925,-0.0058753286,0.0121135535,-0.02337151,-0.027633632,-0.0055942503,-0.01834975,-0.022122711,-0.0018004572,-0.039677333,0.047772877,0.003326158,0.032871235,-0.0050559957,-0.044342484,0.012312099,0.03093675,0.00234548,0.03956966,-3.78967e-08,0.015630567,-0.042161703,0.052517507,-0.071135,0.023992803,-0.012126036,-0.05218229,-0.05032477,0.0016736374,-0.10204637,0.05536776,0.075147465,0.052444417,-0.0014265657,0.013358462,-0.020742385,-0.03589952,-0.022144493,-0.057114065,-0.07680856,-0.14649676,-0.022963716,-0.12194874,0.06541273,0.06926612,-0.058064796,-0.032310136,-0.0062032696,0.008115459,-0.019556973,0.04815393,0.008846447,-0.1063118,-0.06150967,-0.07567819,-0.012480619,-0.046435706,-0.05209503,0.0020381508,-0.0047246027,0.045817517,0.04621671,-0.064834096,0.014067232,-0.048224974,0.07244651,-0.07989783,0.07469631,-0.119676515,0.00978584,0.019922689,0.010268503,-0.07326696,-0.008768978,-0.10939819,0.060673773,0.03193951,-0.029318018,0.0039086277,-0.04562673,-0.038353983,0.012954769,0.14116581,-0.110323206 +6.2.1.41,"The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol and cholate. The enzyme is very specific for its substrate, and requires that the side chain at C17 is completely removed.",384,0.99999994,-0.041317735,-0.0556932,-0.056690652,0.0154223265,0.008417502,0.025999049,-0.044073086,0.08358382,-0.053862542,0.011912674,-0.03843703,0.032033786,0.029136263,0.04998451,-0.037247878,0.08000072,-0.058676474,-0.027713517,0.022312073,-0.02010168,0.0011296696,0.027525954,-0.036456812,0.02353278,0.015941711,-0.01020512,0.0315212,-0.025668541,-0.06485392,-0.10266964,-0.0008214718,-0.02783129,0.08737622,-0.049832534,0.057183772,0.033955794,-0.00884076,-0.027088324,0.10485318,-0.010607073,0.03737914,-0.01006717,-0.011361865,-0.015410144,0.015032253,0.005761234,-0.023665436,0.03314467,0.00026401557,0.04307636,-0.08057709,-0.030202603,-0.083294846,0.02700842,0.033438217,0.02506504,-0.07662647,-0.041130155,0.061945286,0.0027381673,0.03947777,-0.0009868796,0.046404287,0.03737402,0.043244522,-0.07057945,0.02264864,-0.07013655,0.025380868,0.027422024,-0.088565916,-0.07772285,-0.11371846,0.041806445,0.051647518,-0.03395858,-0.078945965,-0.04962781,0.0063837906,0.03401449,-0.046283625,-0.031582568,-0.020122692,0.058320384,0.05519882,0.024433384,0.07941099,-0.015537103,0.054112952,0.03176256,0.037790395,-0.0016877681,0.03133906,-0.023064146,-0.067079924,-0.053284485,0.059972752,0.040215965,0.027707528,0.016555704,0.041490305,0.031103266,-0.012122519,-0.0805713,-0.06041715,-0.021994589,0.006642661,0.07267015,0.06437152,-0.0152551355,-0.012162157,0.0135377785,0.030063512,-0.041179847,-0.01150525,0.09070393,0.096482635,-0.025723252,-0.09742008,0.061888594,0.054604612,-0.056570537,0.012128679,0.005157114,-0.060094744,0.028710747,-0.039798565,9.2825455e-34,-0.011203329,-0.09103545,0.03464873,-0.0037202553,0.01928315,-0.028072499,-0.051911104,-0.011392139,-0.017499859,-0.03627793,-0.025852391,-0.07463992,0.013434433,0.058630876,-0.06584133,0.030053921,0.02103251,0.025135215,0.07006104,0.06702705,0.005057265,0.041745316,-0.054474782,0.014254533,0.0076506785,0.058482505,-0.023751857,0.05625743,-0.021361955,0.00027736722,0.01282266,-0.05950954,-0.15289865,0.011608421,0.03568311,0.0037176139,-0.0474862,-0.040605955,0.036589198,0.083523564,0.0018112828,-0.0018004775,-0.031758364,-0.02924573,0.04279552,0.013060832,0.0127538815,0.07471386,-0.011414858,0.012769361,0.06385477,-0.056325473,0.090743795,-0.0038322797,0.01997416,0.047222406,0.009477337,0.03544422,0.02544734,0.019773325,0.101403676,0.036642402,-0.10217796,0.07853471,-0.03986371,-0.018892337,-0.06640676,-0.006431921,0.021096837,0.018082555,-0.030666979,0.0150923515,0.011418392,-0.018369254,0.05673423,-0.005112738,-0.091496706,-0.035282556,0.033891756,-0.06460321,-0.042325,-0.0012704442,-0.02382419,-0.08441425,-0.03698263,-0.02714803,-0.06222577,-0.11574892,-0.051243633,0.024429023,0.011895986,-0.071301326,-0.13953884,0.08109409,-0.01279992,-2.2089548e-33,0.054723214,-0.105547525,0.05081752,-0.047437582,-0.06755036,0.0035717748,0.05842745,-0.029349852,0.05112883,-0.044201225,0.032937307,-0.014259292,-0.00030177968,-0.0011842818,0.05099266,0.080973074,0.026661668,0.00073146005,-0.06281031,-0.032427028,-0.041382663,0.09026636,-0.003298052,0.03228735,-0.05381878,0.06245163,-0.043914925,0.025570383,0.16329063,0.08276388,-0.04894684,-0.02181244,-0.011151586,-0.042673253,-0.14549778,0.03411388,-0.07333674,0.0076667154,0.06452921,-0.077023216,0.014857947,0.08356994,-0.012173705,-0.02659359,0.035960127,0.04237039,0.00046617942,0.040171534,0.017629076,-0.048674785,0.025155367,0.023425614,0.04513418,-0.009916363,0.009020088,0.084746666,0.035680912,-0.05646027,0.025325472,-0.0645231,-0.06804898,0.037930593,0.011529749,0.030718101,0.05081308,0.120227836,-0.008357293,0.017061263,0.029903911,-0.07634502,0.051473074,0.041274045,-0.017230827,0.036017716,0.031901333,-0.0036850637,-0.0710802,0.008310542,-0.01742701,-0.009216121,-0.0313752,-0.024020992,0.0034338615,-0.10358523,-0.060538515,-0.09688096,-0.062061086,0.04387115,0.023865337,0.05231324,0.029178096,-0.0010612367,-0.0904588,0.05305957,0.042200215,-3.3707067e-08,0.025195258,-0.07680434,0.04644207,-0.03961814,0.0015814302,0.028147535,0.012134655,0.04855467,0.12882285,-0.020415196,-0.0064355545,0.1133266,0.007358628,-0.004264554,0.044994794,0.06286956,-0.023192178,-0.0588451,-0.028296156,-0.01415063,-0.07142013,-0.04865895,-0.03228788,0.07679438,-0.017208327,-0.056847647,0.025379645,0.10691022,-0.028896527,-0.01695237,-0.014432328,0.03695296,0.0011583206,-0.020954635,-0.06127101,-0.0008387892,-0.012075239,-0.053620756,0.04232093,0.09626067,0.029397834,-2.8188284e-05,-0.07894143,0.0007795681,-0.02273376,-0.024201218,-0.078690216,0.018038355,-0.018884208,-0.013708128,0.038007777,0.011788166,-0.072013505,0.019128995,-0.04865284,0.0336128,0.033074833,-0.007942073,-0.054385796,-0.04914182,0.038575705,0.04277413,0.23009,-0.036836334 +6.2.1.42,"The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol. It is responsible for the activation of the C8 side chain. 3beta-hydroxycholest-5-en-26-oate can also be used as substrate.",384,1.0,-0.08007132,-0.047362767,-0.06906753,0.005616208,-0.023726152,0.04973196,-0.017409164,0.11063548,-0.017929535,-0.008593449,-0.041139923,0.018860439,0.0035107636,0.028624462,-0.023370977,0.08141763,-0.0509106,0.0060130195,0.017297717,-0.0400482,0.021215092,0.025895242,0.0038531378,0.0014042842,-0.039719813,-0.027671918,0.06329523,-0.028597144,-0.09939908,-0.13549414,0.024891473,-0.02275896,0.056035887,-0.055145677,0.018416205,0.061537124,-0.022370756,-0.06505931,0.056897666,-0.024537114,0.041672163,-0.033371333,0.0037251932,0.008366976,0.014063786,-0.05367704,-0.034797046,0.06875279,0.040406317,0.048120458,-0.06120085,-0.051358245,-0.062244862,0.021442886,0.043741427,0.044921327,-0.054406248,-0.007851155,0.06954871,0.0023562885,0.044796634,0.020457333,0.043767754,0.030942885,0.0009739479,-0.072163485,0.012410488,-0.04230322,-0.010707649,0.028266368,-0.08815519,-0.07227617,-0.10897501,0.059245992,0.032387592,0.003636963,-0.06371361,-0.07095392,0.024075905,0.013374399,-0.04874799,-0.03990479,0.006015991,0.0985271,0.05456819,-0.0094841225,0.047589812,-0.010388122,0.06679048,0.054199617,0.010969199,-0.01281121,-0.00861872,-0.024310675,-0.055659924,-0.045801673,0.060192846,-0.01300831,-0.010240216,0.022574965,0.03064243,-0.004526489,-0.01467186,-0.029729737,-0.05909237,-0.018089056,0.013983838,0.043839164,0.05537033,-0.026210966,-0.028424507,0.0032780613,0.008615809,-0.08129629,-0.027840972,0.06885797,0.055015456,-0.053848848,-0.0757567,0.0025798336,0.015053085,-0.028985122,-0.020635799,-0.038471498,-0.08341401,0.044793136,-0.024408154,1.0995598e-33,0.050792854,-0.07846507,0.0032988924,0.005221287,0.020841513,-0.0033949516,-0.04002975,-0.008874033,-0.0023559374,-0.08329126,-0.02912886,-0.06549115,0.027917681,0.050867844,-0.022319375,0.035711665,-0.0131800845,0.06189867,0.09242589,0.03962155,-0.0086311875,0.021584313,-0.023027316,-0.010188,0.004200787,0.042413376,0.0070733526,0.029340232,-0.0021490245,0.0040410706,0.019475559,-0.046738196,-0.12547702,-0.02000861,0.07091118,0.0085283825,-0.04951843,-0.03174579,0.037233137,0.0699785,0.053519882,-0.0035454233,0.019712932,-0.043833535,0.033999696,0.046300277,-0.02374865,0.07596805,0.020592023,0.05377961,0.09157769,-0.03893368,0.06826286,0.037787538,0.03192987,0.07479005,-0.034908272,0.05777241,0.035846565,0.016119229,0.07490405,0.06509791,-0.054574948,0.061623503,-0.06801446,-0.008644548,-0.078727566,-0.025108816,-8.171519e-05,0.028524337,-0.015135735,0.03463316,0.029168991,-0.008262498,0.035941567,0.019824922,-0.12704259,-0.020856544,0.04900606,-0.04957793,0.0011282357,-0.013522346,-0.010041966,-0.10670505,-0.023317924,0.0077402974,-0.057998393,-0.0858439,-0.05805393,0.020339655,0.0075080683,-0.08054444,-0.107732154,0.07724297,-0.029535383,-2.5568183e-33,0.034340497,-0.121905535,0.095860526,-0.08163419,-0.02337502,-0.027065674,0.06773791,-0.059286557,0.047448047,-0.025076736,0.0009566787,0.031031158,0.0253586,-0.013419814,0.07613519,0.034307636,-0.037272803,0.013603479,-0.038837112,-0.040631115,-0.016948331,0.092213765,-0.00044938878,0.10197834,-0.016756175,0.03431407,-0.04521705,0.023021108,0.14265628,0.08673196,-0.007624121,-0.0160031,0.0038132966,-0.022072088,-0.097877,0.06250939,-0.02731698,-0.018622188,0.069419734,-0.07403079,0.010683708,0.054939564,-0.0048303814,0.00808925,0.011800765,0.097895056,-0.015711695,0.06260582,0.0026312498,-0.033555392,-0.0042406637,-0.021763315,0.0072264113,-0.011955699,0.010696179,0.059875436,0.026271189,-0.06909109,0.044059932,-0.06560595,-0.06163777,0.03588958,0.0541327,-0.0094492715,0.030568775,0.14103864,0.029212259,-0.008152266,0.039176624,-0.047270328,0.07816126,0.05038759,-0.030200604,0.036805823,0.031480145,-0.040335413,-0.062795825,0.043497518,-0.014112195,0.0070382664,-0.047075886,-0.018876038,0.025840448,-0.10598815,-0.040991098,-0.12307511,-0.025022274,0.035284594,0.041498166,0.08237738,-0.00095767656,0.04106725,-0.10702486,0.070530504,0.04450939,-3.613237e-08,0.04985579,-0.09338971,0.047289073,-0.015888719,-0.058684025,-0.016797544,0.0053528645,0.051090907,0.14322168,-0.046537317,0.0058987923,0.12792544,0.008094509,-0.023490975,0.04705412,0.015176563,-0.01681827,-0.020136226,-0.046201658,-0.016415967,-0.0644951,-0.020857917,0.0084674405,0.0785943,-0.026564669,-0.053301472,0.015686026,0.05338603,-0.0051375018,-0.026154106,0.011588893,0.06749184,-0.010056355,-0.004741122,-0.054153312,0.008247449,0.006598668,-0.026051635,0.027482308,0.110139325,-0.009061559,-0.02373876,-0.06335417,-0.01381181,-0.028373128,-0.036249656,-0.10144466,0.050932012,-0.024110964,-0.045699123,-0.03260665,-0.009479416,-0.060793824,0.01801341,-0.064579025,-0.012903872,-0.015956813,-0.046624385,-0.044070747,-0.041280348,0.024553632,0.033269938,0.24543442,-0.02712016 +6.2.1.43,"The enzyme from the bacterium Streptomyces carzinostaticus is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1-naphthoate moiety of the antibiotic neocarzinostatin. In vitro the enzyme also catalyses the activation of other 1-naphthoic acid analogues, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate.",384,1.0,-0.046083525,0.0011287779,-0.15940836,0.050505072,-0.0335722,0.064067096,-0.024773233,0.068035506,0.07933299,-0.06548136,-0.062195435,-0.0404853,-0.0010800352,0.08679897,-0.0763537,-0.036943384,-0.071947,0.028070701,0.08635168,-0.057840973,-0.007693972,0.09901782,0.049729165,0.013526659,0.036765553,0.022611653,0.030136922,0.0061947005,-0.04225812,-0.010663006,0.009073101,-0.062080953,0.00419201,-0.009944103,0.048259657,0.08668975,-0.02777516,-0.044397656,0.07201225,0.050363224,0.005108438,-0.042969164,-0.029752955,-0.01167983,-0.047214605,-0.017127061,-0.013209509,0.07900806,0.038482904,-0.003976451,-0.052189708,-0.07801885,-0.056494597,0.06396837,0.06952388,0.007804033,0.010920577,0.021230912,0.014179901,-0.023293292,0.12761912,-0.0036642281,0.017643616,-0.036573734,-0.0707997,-0.088889964,0.06448509,-0.10078983,0.0071555953,-0.004959005,-0.08023031,-0.035670076,0.03439699,-0.010226302,-0.032502897,0.023395268,-0.0053259577,-0.03570633,-0.021005172,-0.020057263,0.0998942,0.019356683,0.0085168285,0.1056622,0.0028000798,0.023230974,0.024249744,0.034750443,0.04908528,0.023649301,0.052648365,-0.0121224765,-0.076218344,-0.032174814,-0.117356405,-0.10497404,-0.019560615,0.052975196,0.020604687,-0.033550214,-0.027096044,-0.002305206,-0.018986847,-0.038485743,-0.0011399151,-0.0026113375,-0.01576458,0.08696674,0.04062485,-0.087946944,-0.021820696,0.03383397,0.008453055,-0.030087462,-0.05934584,0.07840348,0.045463637,-0.017847061,-0.07576417,0.046558302,-0.001414662,0.004529218,0.029972952,0.011680094,-0.016416436,-0.0050244206,-0.09492155,3.8571312e-34,-0.00031002634,0.096518874,0.030276174,-0.014423115,0.04699759,-0.0050775483,-0.08579795,-0.005838703,0.01693696,-0.026618322,-0.027727801,-0.029887663,0.056721352,0.02566477,-0.006785429,0.0012921722,-0.07118581,-0.02323324,0.027925074,-0.007433728,0.019809257,0.023562623,-0.039796587,-0.012711094,-0.0038043964,0.069752716,-0.009935519,0.09798767,0.006195996,-0.023224175,0.009591724,-0.064795285,-0.056903597,-0.014714149,0.10421706,-0.03615407,-0.022324456,-0.047778256,0.087477565,0.014615624,-0.026933478,0.011798044,-0.028160952,-0.020939909,0.03579714,-0.05499485,-0.055410005,0.121578574,0.040585328,0.058118213,0.091615066,-0.07693697,0.04573591,-0.02646941,-0.09955095,0.027586011,-0.016246632,0.020219926,0.037516713,0.074949116,0.04192083,-0.057409447,-0.014195474,-0.015358658,0.024017924,0.009706523,-0.025720963,0.03331966,0.01297185,0.03228664,-0.06747518,0.059818137,0.07377654,0.00025240335,-0.01492305,-0.012599827,-0.06584788,0.018482352,0.08855521,0.031497136,-0.036628958,-0.029032331,-0.019829042,-0.03351604,-0.06974639,0.09503548,-0.003995193,-0.012402196,-0.026731025,0.06864393,-0.032439224,-0.12201029,-0.0842319,-0.035246734,0.05592549,-2.8623194e-33,0.102056466,-0.07113142,-0.008307714,-0.08043062,-0.006203445,0.048568312,0.019855117,-0.083298065,-0.085057415,-0.022938138,0.10098017,0.040294748,-0.015542868,0.025104066,0.0016998615,-0.036457017,-0.028789813,0.017961724,-0.015807796,-0.012152231,0.040587682,-0.0070122173,-0.071514845,0.07173166,0.039941248,-0.01900652,-0.0018567358,0.066174895,0.049483653,0.09498463,0.046957403,-0.07821791,-0.04608467,-0.057688467,0.019958476,0.11604191,0.006069082,0.039381266,0.058914427,-0.044992577,0.03653443,-0.036683075,-0.04263988,0.05685019,0.04890035,0.10480797,-0.046008725,-0.012075443,-0.013215455,-0.024633624,0.0064583253,0.058774587,-0.044085115,-0.02485056,-0.06568202,0.042242855,-0.0062963166,-0.052341957,0.04997213,-0.0046185236,-0.0048494134,-0.015122461,0.029263938,0.0089314375,0.021489829,-0.013890076,0.028523535,0.021077463,0.16430338,-0.09091005,0.0114293825,-0.027586907,0.014404699,0.044211984,-0.12172569,-0.05978184,0.015629962,-0.0076928623,0.03075528,-0.008786333,0.03735152,-0.03501308,-0.001204128,-0.084840104,0.012523054,-0.0041355365,0.045430526,0.053674214,-0.012476384,0.023514505,-0.027792498,0.052007113,-0.053428132,-0.039762374,-0.020600788,-4.3953307e-08,0.07078877,-0.11402502,0.076892644,-0.050492704,0.011793503,-0.035659857,-0.047616486,-0.035755903,-0.030955046,0.00087077403,-0.008869534,0.049640205,-0.0065085087,0.0354517,-0.055822127,0.027177786,-0.069641985,-0.010537189,0.012482468,-0.0026187124,-0.11431271,-0.0053693014,-0.08629993,0.015469161,0.0708894,-0.06619016,0.019625945,0.03376195,0.023986742,-0.003718552,0.0685989,0.021355934,-0.0052872477,-0.019365754,-0.029004216,0.012090938,-0.09025366,0.016766261,-0.018383518,-0.019970626,0.04559555,0.016832458,-0.05073776,0.020536859,-0.007954714,0.043342296,-0.053409778,-0.050800182,-0.023818528,0.020530442,0.100483306,0.0007101278,-0.027549274,0.028865993,-0.107206345,0.033794113,0.014152805,-0.060034696,-0.007603609,0.015817758,-0.04549689,0.0037925541,0.19429126,-0.05238611 +6.3.1.18,"Requires Mg2+. The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the first step in the degradation of aniline. It can also accept chlorinated and methylated forms of aniline, preferrably in the o- and p-positions.",384,1.0,-0.10769842,-0.040133696,-0.033137556,0.052445292,0.0077912104,-0.0026133372,-0.006330663,0.0051751947,0.02546451,0.031200938,0.0025011213,0.02346529,0.0017722654,0.08097481,-0.03283486,0.0729274,-0.053067423,0.050445914,-0.01358169,-0.035080943,0.076184675,0.0025517812,-0.04901622,-0.039626908,-0.013189212,0.013925044,0.014988169,-0.009668957,0.054803755,-0.084664814,-0.0141274985,-0.025706934,0.09809312,-0.038946252,0.06068104,0.11858503,0.018793494,-0.056016054,0.031667158,-0.046568524,-0.024434287,0.0001593826,-0.02673133,-0.023873731,0.037748225,-0.068407305,0.044365305,-0.018845579,-0.0021442138,-0.0348791,-0.028941693,-0.010378484,-0.067791075,-0.028094348,-0.027468104,-0.037285406,-0.049375594,-0.04006524,0.012744207,0.0053438195,-0.006097362,-0.0020146898,-0.07400481,0.0013355229,0.045677416,-0.07661381,0.09017232,-0.05872346,-0.02511812,0.019605584,-0.014382968,-0.13543232,0.01462034,0.041264802,0.023787003,0.022317108,0.041135367,-0.06293016,-0.008608798,0.012306687,0.032122,-0.032180276,0.053973082,0.08765839,0.10333716,-0.032631166,-0.025894664,0.0028237975,0.050461497,0.10950425,0.017254638,0.10249406,0.032355737,-0.031033717,0.049819257,0.03954365,-0.0150676,-0.035877384,0.0042998786,0.016063206,-0.02357889,0.08452354,-0.050337143,-0.0019803643,-0.0035911398,0.014202956,-0.025354996,0.009189179,0.11120328,0.042511743,-0.00333251,-0.0048362385,-0.004605459,-0.0048554754,0.021298448,0.07700596,-0.021646317,0.0069591594,-0.0453319,-0.03228994,-0.033608295,-0.026096929,-0.06257555,0.046270274,-0.046509627,0.041335832,-0.10757493,3.6008875e-34,0.023770085,0.04590146,-0.039516088,0.017500184,-0.06879247,-0.01082792,-0.0684581,0.01661456,0.0051700925,-0.121946394,-0.040893245,-0.09292199,-0.055150274,0.022120627,0.0024775818,-0.038006477,-0.005430192,-0.021822087,0.05131475,0.00074094755,-0.06628646,-0.020832207,0.031565618,0.023020064,0.094433635,0.050868258,0.080733426,-0.039610412,0.006531247,0.0006365522,0.007720512,-0.10183401,-0.09211987,0.029111529,0.06998471,-0.016315468,-0.036872946,0.0374221,-0.013088722,0.09331707,-0.07002568,0.03266492,-0.056089837,0.033072807,0.060337324,-0.022505155,-0.018780345,0.10356612,-0.0010255638,0.053678,0.032688826,0.030313157,-0.03239628,0.0072699534,-0.11300778,0.06307429,-0.0042439206,0.005654913,0.07203532,-0.017445384,0.057853054,0.026183348,0.03245076,0.0065886597,0.03517492,0.051265392,-0.104659006,-0.012234153,0.01180368,0.046584833,-0.04933977,-0.014052574,0.07107623,0.06352744,0.029275034,-0.045055363,-0.0031488163,0.0061957096,0.08656147,-0.056280784,-0.03231159,0.005173199,0.04976334,0.017877905,-0.12269412,-0.046917856,0.035414774,-0.022255283,-0.017272795,-0.051028334,0.08124522,-0.069445506,-0.0233402,-0.020895412,-0.009531678,-1.0874579e-33,0.08886636,-0.018332928,-0.007400667,-0.020965107,-0.062468596,-0.050785758,0.039750528,-0.089521326,-0.00051873137,-0.007524758,0.025880713,-0.012088479,0.039846897,-0.0647636,0.022184586,0.053407636,0.028775148,0.057734434,-0.07575098,-0.05492092,-0.008612641,0.07426154,0.047296576,0.02551917,-0.011606854,0.06526878,-0.042581107,-0.0007108653,0.09832679,0.07212171,0.014778843,0.07789249,-0.019407129,-0.09196648,-0.055048507,0.092149496,-0.0077122985,-0.037759572,-0.0362898,0.07814063,0.09353316,0.02553984,0.019114736,0.054776076,0.0139962295,0.07976499,0.046503853,0.017710194,0.023103356,-0.1593893,0.10686245,0.027177602,-0.03895179,-0.041320052,0.029033177,0.020096578,0.03772888,-0.036778767,-0.043074507,-0.038268,-0.03942321,-0.03643623,0.10215646,-0.04739755,0.0011857027,0.024197929,0.07689332,0.063508496,0.031023074,-0.016018996,0.07507241,0.051071882,0.04749312,-0.021180365,-0.039428625,-0.023839664,-0.026734034,-0.0435909,0.020293456,-0.06824735,-0.053008214,0.064235136,-0.030507125,-0.029447544,0.0012184089,-0.07932393,0.012076237,0.02836651,0.004367071,0.011423665,-0.0010969274,-0.009212805,-0.04569387,0.07788405,0.042947873,-3.5893812e-08,-0.011912482,-0.10105365,0.045460675,-0.021632567,0.07079447,0.08722653,-0.032034054,0.020458749,0.11080559,-0.082528956,-0.05365364,0.02247459,-0.032574277,0.0018079396,-0.028818153,0.04901264,-0.0443493,0.03537041,-0.031271152,-0.056454156,-0.08575698,-0.008246857,-0.15292768,0.03165003,0.0259216,-0.043948572,-0.054089736,0.0056428444,0.022551375,-0.0017917395,0.014147845,0.048149094,-0.020011459,-0.055075243,-0.045258157,-0.014362531,0.08770148,-0.07316896,-0.044668186,-0.026734328,-0.02810543,0.06618319,-0.048694868,0.04714608,-0.009857023,0.004879548,-0.0166351,-0.004003265,-0.07578388,0.04069138,0.10173512,-0.060933467,-0.024113983,0.016740149,-0.07495271,-0.047542058,0.020169752,-0.073238984,-0.0117688235,-0.109712735,0.020282852,0.0045743594,0.1362562,-0.03661377 +1.1.1.375,"The enzyme from the archaeon Methanocaldococcus jannaschii catalyses the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3-sulfolactate has the same stereochemical configuration as (2S)-2-hydroxycarboxylates) [1]. The enzyme can use both NADH and NADPH, although activity is higher with NADPH [1-3]. The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP+ [1]. The same organism also possesses an NAD+-specific enzyme with similar activity, cf. EC 1.1.1.337, L-2-hydroxycarboxylate dehydrogenase (NAD+).",384,0.99999994,-0.050148442,-0.059181526,-0.0765794,-0.02471637,0.026527936,0.043300383,-0.1452906,-0.0013678272,0.06700389,0.02849095,-0.07529854,-0.013859352,-0.12576352,0.035151575,-0.044864614,0.044400625,-0.04661955,0.022466065,0.07354195,0.054865614,0.08830066,0.026849233,-0.01740877,-0.013474545,0.10487649,0.0690985,-0.0023362306,0.012865629,-0.058810074,-0.053403735,0.027254058,-0.006277128,0.03815746,-0.07793412,0.028641777,0.08162631,-0.038184434,-0.07662048,0.07209304,0.0127664395,-0.024452243,0.039745435,0.0031808987,-0.059147738,-0.055813108,-0.02921829,-0.020420283,0.007182689,0.08971418,-0.039924894,-0.052804448,-0.027339052,-0.030780522,0.03603466,0.020331912,0.030654093,0.02317464,-0.0055560293,0.026111364,-0.05092173,0.0053438037,-0.030157646,0.04381531,0.0072547346,-0.022303332,-0.044692215,0.030734874,-0.10178202,0.044467885,-0.068286575,-0.13815337,0.015569806,0.014440042,-0.014304793,-0.050941635,0.047198057,-0.014007636,-0.04386011,0.022267027,-0.06116975,0.023487791,0.041080095,-0.005334326,0.042418014,0.013688918,-0.022267934,-0.012514896,-0.005437359,0.050759636,-0.005126489,0.010624325,-0.019457085,-0.020162096,-0.04990485,-0.051291615,-0.03734119,0.04444776,0.119314745,-0.0028648768,-0.022887612,0.07015513,0.05891766,-0.003387379,-0.10190532,0.004905346,0.04508973,-0.039394945,0.103162654,-0.014251517,0.061468977,0.03171927,-0.0031469136,0.055276677,0.009553498,-0.07177883,0.10571618,0.0033941525,-0.070004545,-0.14914905,0.020639969,-0.0045804707,-0.06774284,0.07717308,-0.057647936,-0.012379102,0.015721247,-0.07559571,1.723055e-33,0.078398444,0.014228609,-0.013963394,-0.035077333,0.073106535,-0.03837589,-0.0759204,0.07104415,0.032342814,0.011335526,-0.063849516,0.015178503,0.036305662,-0.010291037,-0.014379013,0.04755327,0.015602589,-0.08603668,-0.017057374,-0.02978479,-0.012109953,0.017394807,-0.009387021,-0.021039085,0.032177933,0.0014756767,0.03438734,0.020654233,-0.008329334,0.002184747,0.11493868,-0.12903267,-0.072514854,0.030195715,0.10015526,0.011123113,-0.022799786,-0.07645335,-0.014711924,0.00024577277,0.008056632,0.01993641,0.01726322,-0.06837361,0.016770737,-0.05137923,0.0080729015,0.118481465,0.045684293,0.018978983,0.02947592,-0.022039162,0.048195418,-0.012373234,-0.036658693,0.007074278,-0.011545044,-0.034715604,0.10704969,0.098629735,-0.03314107,0.029224286,-0.0034554617,0.011490821,-0.04453671,0.020535633,-0.09728948,0.010883642,-0.009559205,0.048605405,-0.0014812474,0.006669221,-0.0057666083,0.06497878,-0.020326622,-0.00039621632,0.034407604,0.025326403,0.03534241,-0.002956987,0.029289968,-2.6860816e-05,-0.010576641,0.020155204,-0.071985275,0.045297887,0.032277543,-0.009669712,-0.054710828,0.07812065,0.003968566,-0.085500255,-0.05368787,-0.0035251281,0.041465927,-3.949284e-33,0.08184579,-0.062067572,0.035462987,-0.1657814,-0.035632167,0.10872116,0.04389084,0.004783338,-0.0046089264,-0.084505424,0.040402282,0.08016313,0.044321485,-0.047970958,0.047574416,-0.04705496,0.03541415,0.032507695,-0.0261262,-0.0027255048,0.046179265,0.13212466,-0.03552257,-0.031407967,0.022264266,-0.041355334,-0.019924017,0.028662695,0.008212234,0.09135971,0.03369691,0.015000179,-0.014785262,-0.070962034,0.0013603067,0.0061003314,-0.063148096,-0.049204096,0.00067252683,0.06756787,0.03332434,0.019065754,-0.038408,0.041765276,0.08867334,0.004091913,-0.15605001,-0.021805625,0.01583301,-0.091988705,0.029021492,-0.010658858,0.017971758,-0.010047212,0.06482668,0.06653138,-0.029222198,-0.0012522531,0.043142885,-0.023314206,-0.03764939,-0.024800442,0.074158475,-0.07262468,0.02076254,0.050600953,-0.029785646,-0.037573233,0.0328938,-0.004069246,0.022686595,0.032259453,-0.029006837,0.025314381,-0.05281324,-0.033097837,-0.11307084,0.06467374,-0.003858672,0.0041122963,0.03206185,-0.034197036,0.04834587,-0.07160802,0.018824805,-0.0354683,0.037935436,0.080835044,-0.04713488,-0.021344721,-0.0037854908,0.008984018,-0.09791316,0.03345393,0.029935805,-4.4111307e-08,0.0041638906,0.028382337,0.104888126,0.02362077,-0.052605018,0.04255354,0.08317574,-0.0094852615,-0.016373029,-0.024033237,0.023900606,0.12898567,0.0046801222,-0.03801122,0.0075242794,0.036811545,-0.08001374,0.013677522,-0.032546584,0.044884823,0.008477762,-0.016447064,-0.04515975,0.044031903,0.032850858,-0.053379867,0.040008537,-0.08036147,-0.02263728,-0.022122866,0.018246502,0.04276163,0.02496515,-0.055440556,-0.06478526,-0.054592207,-0.07704414,-0.04862339,-0.051453818,-0.010256498,0.033672918,-0.038549565,-0.055808302,0.045996264,-0.0058080964,0.008275513,0.037771072,0.02382864,-0.09832575,-0.04087783,0.102161415,0.017893381,-0.015713628,-0.038487136,-0.08125936,-0.0012252914,0.015869655,-0.03939515,-0.0834,0.008496177,0.05538352,-0.046768803,0.108156845,-0.016614553 +1.1.1.376,"The enzymes from the bacterium Azospirillum brasilense and the archaeon Haloferax volcanii are part of the L-arabinose degradation pathway and prefer NADP+ over NAD+. In vitro the enzyme from Azospirillum brasilense shows also high catalytic efficiency with D-galactose. The enzyme is specific for alpha-L-arabinopyranose [3,4].",384,0.99999994,-0.037590872,-0.01556231,-0.06564462,-0.03906209,0.03908394,0.0800433,-0.07888151,0.032147508,0.08320747,0.07936341,-0.029297704,0.018710217,-0.03094518,0.022008767,-0.028802494,0.042496502,-0.024067795,0.023310294,-0.0023529914,-0.002955417,0.11799147,0.018394953,-0.03728493,-0.0022839403,0.10695374,0.0014605738,0.019156631,-0.07675143,-0.06589011,-0.04423244,-0.01135189,-0.03389186,0.12119686,-0.08202106,0.04964762,0.083534464,-0.018190434,-0.102641076,0.08035012,0.0020006355,0.048253004,0.018310469,0.027058013,-0.049876593,-0.08642712,0.027207827,-0.0069614057,0.055509772,0.05717511,-0.00472041,-0.06600294,-0.0725536,-0.040473644,-0.025728026,-0.0012964748,0.03117625,0.01565502,-0.0254131,-0.04334664,0.00802919,0.041927826,0.048391517,0.027330657,0.032009482,-0.03984381,-0.060338575,0.08671702,-0.056951232,0.0070546777,-0.037596967,-0.084825315,-0.014928886,-0.055026054,-0.004345374,0.017564442,0.05658871,-0.0015762382,-0.06801619,0.0046428577,-0.048432864,0.058280878,0.010612505,0.012962576,-0.0024473923,-0.014734614,-0.036353342,0.059612185,0.010327987,0.0829327,-0.0024800946,0.06359465,-0.015807856,0.04292689,-0.034770835,-0.06168675,-0.027085818,0.015471595,-0.004029094,-0.008612639,-0.05443765,0.035212286,0.019585663,0.0010566524,-0.12270969,-0.04871502,0.03415963,-0.037422925,0.11800847,-0.0009397856,-0.011713497,0.020143043,-0.026438817,0.024154909,0.019496638,-0.048800997,0.09043134,0.046897233,-0.10052592,-0.1250578,0.0431386,0.009176921,-0.082687125,0.080147,0.024184588,-0.031334892,0.06879786,-0.11747357,3.3093035e-33,0.0571374,0.0531869,-0.06614004,-0.0586246,-0.043946892,0.0034106765,-0.065967955,0.03434763,-0.042588543,-0.088884726,-0.055143498,-0.031021597,0.0015365842,0.053157635,-0.005988749,0.097001016,0.013048962,-0.030620206,-0.016857952,0.06400272,-0.01014222,0.00826025,0.0040069805,0.02124033,0.084431425,0.10223513,0.040668998,-0.038702317,-0.0069779907,-0.0033843636,0.040783748,-0.08910208,-0.13701862,0.002027452,0.05153873,0.039097246,-0.060441058,-0.013714152,-0.050906517,0.025652904,-0.06505255,0.05181344,0.0014897633,-0.013880777,0.04438391,-0.028341996,-0.029109254,0.052671954,0.06825086,0.01667949,-0.007892778,-0.0071029756,0.09484215,-0.033692457,0.003440531,0.047375012,-0.039910983,0.035200663,-0.007127194,0.042574838,0.053348493,0.046909735,0.005464995,0.08685443,-0.06063253,0.038623236,-0.027519587,-0.028573858,0.029011015,0.071026176,-0.014582168,-0.057915404,0.07669489,0.049144562,-0.024961969,-0.08326645,0.023475895,-0.040340956,0.02078705,0.014612681,0.013540881,0.009815005,0.001325948,-0.021488974,-0.026096413,0.04287157,0.03373919,0.0032242225,-0.03909057,0.062313642,0.0070740655,-0.0352902,-0.009176081,0.03172891,0.0037997016,-4.2586805e-33,0.126827,-0.07044689,0.06618358,-0.09851743,-0.06315325,0.07280936,0.0687028,-0.016055694,0.035763834,-0.057518136,0.03269765,0.0028833156,0.02990786,-0.07386983,0.046500098,-0.07589224,0.06928881,-0.007165479,-0.01721447,-0.0074569634,-0.009372146,0.09103024,0.033382293,-0.062495444,0.03234902,-0.09811879,-0.032679632,0.10307991,-0.00800191,-0.021708403,-0.005136521,0.044792447,-0.051149536,-0.060556065,-0.0856238,0.06812541,-0.059079938,0.02137644,-0.01656037,0.026121723,0.03784184,0.023090031,0.01884424,-0.01918361,-0.0065713977,0.03143406,-0.11735055,-0.023904795,0.04610473,-0.048277363,0.031077893,-0.033069253,-0.020172229,0.06369741,0.0127447685,0.024012068,-0.020488447,0.10019858,-0.034919463,0.0019645682,-0.06698219,-0.044007998,0.09995858,-0.026730243,0.050501294,0.042259093,0.04493633,0.0074890023,-0.015911067,0.016737001,0.09971434,0.021396954,-0.022245156,0.11707958,0.0075869286,0.028878136,-0.16096245,-0.048641846,-0.03596451,-0.0841849,0.038067434,-0.0015866221,-0.02677818,-0.017563337,0.014931134,-0.035358213,0.035825793,0.079382315,-0.018791564,0.00582765,-0.0064743673,-0.07592055,-0.020096298,-0.04058663,-0.0044051176,-3.6588773e-08,0.020354174,-0.009017135,0.047531873,-0.063477,-0.019226275,0.03453544,0.020723391,0.01820778,0.043649055,-0.03527602,-0.0053312113,0.07335676,0.022382911,0.064594366,-0.00252075,-0.037614617,-0.04442941,0.06170129,-0.010774657,0.0257999,-0.065600514,-0.0075543295,-0.11420311,0.004991525,0.026960997,-0.028052406,0.04039234,-0.030093297,0.0005230376,-0.046780016,-0.01683671,-0.00044526008,0.047107525,-0.037071377,-0.071525924,0.0077756215,-0.06676312,-0.022647843,-0.045978628,0.028012095,0.05288164,-0.041689325,-0.0563619,-0.007852127,-0.021394247,-0.01937571,0.042025972,-0.03358132,-0.043044683,0.09349983,0.069224484,-0.041144695,-0.043379683,-0.0780876,-0.025515206,-0.038227867,0.07010965,-0.077094465,-0.0027598261,-0.008161834,0.06628464,-0.06066934,0.13645172,-0.07401447 +1.1.1.377,"The enzyme from the archaeon Thermoplasma acidophilum is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+. ",384,1.0,-0.03516419,0.00510236,-0.08270217,-0.032723658,0.132448,0.086004995,-0.104336396,0.039345074,0.01775429,-0.007029683,-0.00690231,-0.031057976,-0.07732727,0.011007689,-0.051930983,0.002356571,-0.11060958,-0.030250525,-0.0060877996,-0.045109995,0.100111455,0.05530845,-0.022848478,0.010832277,0.0705027,-0.015195469,0.041383993,-0.005341337,-0.03057358,-0.029747713,-0.023388086,-0.005709112,0.061620604,-0.01766,-0.011930177,0.121136844,-0.009278164,-0.09583603,0.037259307,0.0670135,0.008182344,0.050102398,0.010527105,-0.054342728,-0.062507,-0.00078834477,-0.051014487,0.014868986,0.015754014,0.049506415,-0.002823425,-0.058337707,-0.0002955965,0.025838206,-0.008049171,0.068483315,-0.032003757,-0.02447248,-0.055227432,-0.0047784257,0.04359835,0.0045696725,-0.054765444,0.08261477,0.0015990671,-0.07097998,0.09333957,-0.06405566,-0.029969696,0.0035899018,-0.09672785,-0.014053426,-0.021322146,0.01564821,-0.004355633,0.09780523,-0.013574013,-0.08650533,0.0054767346,-0.035589978,0.08231633,0.017531708,-0.03500946,-0.0009873392,-0.010727119,0.014304022,0.047656555,-0.002013978,0.055235494,-0.011764233,0.016658546,-0.050891083,-0.0070682,-0.0186026,-0.039882,0.04976808,0.06689368,0.028930087,0.009048748,-0.09642837,-0.04077918,0.06831735,0.0057288893,-0.06544643,-0.058987785,0.022206863,-0.0757135,0.07184661,0.04328123,-0.00015905677,0.026357155,-0.025165692,0.05997636,-0.019403044,-0.050184116,0.05372102,0.01158707,-0.08706955,-0.11960436,0.012381179,-0.0094097,-0.042721007,0.03299515,0.011752708,-0.04147292,0.014673882,-0.12676823,1.5015428e-33,0.06581091,-0.012374335,-0.047413234,-0.055167943,0.05732124,-0.015427534,-0.08944619,0.013692651,-0.026888462,-0.048415385,0.0020602345,0.036466993,0.021113947,-0.061035722,-0.036140457,0.098987706,0.027420558,-0.017652217,-0.0731698,0.027068399,-0.015362515,0.09491821,-0.030140424,0.0057069617,0.030711282,0.0705864,0.052601032,-0.010117073,-0.030980965,-0.013463529,0.0063151633,-0.10449856,-0.14502761,0.06395892,0.057980202,-0.014030239,-0.043651607,-0.053728137,-0.035280906,-0.016945329,0.04848295,0.020017741,0.008214975,-0.0052273446,-0.0058817267,-0.108489804,-0.018968724,0.055385824,0.016473088,0.09631844,0.007498724,0.022832597,0.072122835,-0.024490492,-0.06343026,-0.024905933,-0.048773043,0.045043286,0.054633833,0.03811797,0.0068614935,0.058305554,-0.0077906204,0.06579957,-0.008580793,-0.020387333,-0.09063506,-0.08433036,0.039547466,0.05413628,-0.017287547,-0.0411338,0.033002865,0.04475151,0.018757919,-0.04815735,-0.0073525,0.019867409,-0.027149312,0.032895043,-0.023290988,0.014376591,0.027101438,-0.0025988717,-0.017139405,-0.019228807,0.05714842,0.022267375,-0.022826253,0.051091854,0.03954195,-0.06982407,-0.010455944,0.05167004,0.020895084,-3.1927874e-33,0.097015396,-0.10661123,0.06582651,-0.10317253,-0.05260349,0.0805406,0.06358197,0.0063231196,-0.016246775,-0.060641356,0.05162623,0.05082057,0.019617606,-0.03382244,0.12468871,-0.04075597,0.037039943,0.02680925,-0.0159502,0.015043211,0.014385091,0.096381985,-0.0060687084,0.008604875,0.01867989,-0.04317438,-0.025706066,0.045167383,-0.032632522,-0.002933008,-0.043528374,0.04588759,-0.049127962,-0.0439699,-0.04491887,0.0189651,-0.009187458,0.019847883,0.042976953,0.02967314,0.048880797,0.033666093,-0.013743495,0.006207948,0.070281014,-0.00077395665,-0.12546094,-0.018221905,0.050658096,-0.007641026,0.011023426,0.00013133681,-0.021172393,0.02040871,0.061039858,0.032709796,-0.097529836,0.05082362,0.021991625,-0.01705921,-0.049992837,-0.058845297,0.0013532629,0.06930719,0.034565706,0.07334599,0.012445058,0.018510226,0.02294602,0.017334586,0.1134126,0.075741924,0.032879803,0.049794987,0.0031825462,-0.09275854,-0.08179166,-0.019766033,0.0056490465,-0.041591134,8.2408464e-05,0.0067454083,0.015936939,-0.030107532,0.045044355,-0.07372413,0.025585532,0.076023124,-0.04476159,-0.055347394,0.06352758,-0.09530344,-0.08352534,0.036695924,0.061537653,-3.2717637e-08,0.05866196,-0.0123356925,0.056756627,-0.07648969,0.047589976,-0.014254784,0.0484057,0.02895975,0.051038995,0.01263184,0.03385832,0.08238639,0.030660285,0.042773634,0.0076620975,0.0030084252,-0.09726821,0.074007966,-0.013521929,0.06475785,-0.02238339,-0.07428894,-0.0655781,0.040867835,0.04009539,0.044048596,0.076750405,0.0020210491,-0.010334168,-0.053221703,-0.020723095,0.0074818456,0.03749836,-0.0063494574,-0.07977341,-0.030790765,0.034794416,0.04660801,-0.09374535,0.021985324,0.025462516,-0.040385995,-0.024820337,0.022643847,-0.013775617,-0.007742155,0.0137854675,0.0058842245,0.0005492717,0.007773526,0.06569888,-0.039383695,-0.023549188,-0.09093797,-0.116965055,-0.13213208,0.043563686,-0.035919424,-0.03138191,-0.04169015,0.07892671,0.005693717,0.16807443,-0.015137017 +1.1.1.378,"The enzyme, which occurs in the bacteria Azotobacter vinelandii and Sphingomonas sp. SKA58, is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+ and EC 1.1.1.377, L-rhamnose 1-dehydrogenase (NADP+). ",384,1.0,-0.04200911,-0.031415608,-0.096309856,-0.031885095,0.11105496,0.09046511,-0.07804127,0.039859593,-0.004628933,0.007890392,0.023295611,0.0073040077,-0.049445838,0.045978107,-0.036798242,0.05594286,-0.08247494,-0.052466787,0.005482756,-0.022846146,0.07048267,0.07398339,-0.060829125,0.0026231431,0.10175416,-0.0007689447,0.05018476,0.013645089,-0.03680912,-0.054185037,0.03665252,0.00059474463,0.06305559,-0.08643944,0.011195427,0.1289395,-0.014972449,-0.0805708,0.08394242,0.07172647,0.0056840456,0.06768516,-0.016218692,-0.030305432,-0.029311705,0.019839209,-0.043199398,0.11453895,0.00792174,0.013428815,-0.05260594,-0.05433531,-6.734043e-05,0.030854879,0.03595834,0.0016975766,-0.02623913,-0.0076139104,-0.059093658,-0.0060667726,0.035283066,-0.023802426,0.0065531055,0.04113182,-0.0043884115,-0.08551069,0.08534906,-0.07370603,-0.023714826,-0.010238858,-0.12642613,-0.051370956,-0.03490517,0.019274699,0.0096429465,0.06870745,-0.027604146,-0.047092058,-0.027067663,-0.030017024,0.040684566,0.007387603,0.014795788,-0.015890792,-0.008278547,-0.02449826,0.05457486,0.0068373056,0.058753546,0.014003489,0.01936085,-0.044636685,0.015232735,-0.037005287,-0.08561781,0.028778912,0.0331864,0.05280167,0.016797608,-0.074716136,-0.017245997,0.056848656,0.005433853,-0.06935419,-0.06805148,0.021329144,-0.048110407,0.12606221,-0.019185055,-0.003941267,0.026376273,-0.0027226782,0.043535266,-0.057865612,-0.047300603,0.036816977,0.028518675,-0.058621313,-0.12234048,0.03408289,0.01830141,-0.058218766,0.03591076,-0.007206574,-0.013399271,0.03392162,-0.15909922,1.8392925e-33,0.0701504,-0.0074113887,-0.039354242,-0.06563761,0.016942233,-0.026831204,-0.09271907,0.03617492,-0.025877338,-0.041768834,-0.02755473,-0.032964684,0.037477825,-0.07249776,-0.0356876,0.11662865,-0.004718915,-0.044389702,-0.028043171,0.08053458,0.0035050171,0.047442734,-0.082057185,0.0065754126,0.038944546,0.11504119,0.05354319,-0.02564925,-0.05001987,-0.022562006,0.054536328,-0.09141082,-0.15682353,0.033207282,0.06620258,-0.048425082,-0.051916145,-0.038329605,-0.036595874,-0.01770219,0.02108066,0.05645785,0.00636355,0.009795917,0.030912606,-0.077147074,-0.029697344,0.03501461,0.05943372,0.089474104,0.025125721,-0.008574235,0.09718036,-0.013675637,-0.040167186,-0.007375038,-0.052043933,0.034915704,0.04639681,0.030712588,0.031496376,0.030649398,-0.018848516,0.036016848,-0.00092702755,-0.029369295,-0.056127794,-0.08334751,0.056274906,0.04951319,-0.057897635,-0.032391705,0.07316261,0.020867446,0.005712169,-0.077648096,-0.015792178,-0.044366848,0.014791103,0.041771244,-0.06464833,-0.009352132,-0.0040574865,-0.041299865,-0.006509056,-0.026301906,-0.0029328025,-0.03697474,-0.011420332,0.020415045,0.057751093,-0.05188144,-0.03774973,0.021956798,0.04665071,-3.1928965e-33,0.09322447,-0.06907252,0.06256056,-0.06466942,-0.032751422,0.080294736,0.06802144,0.007124292,-0.011744183,-0.054890763,0.04780075,0.048985988,-0.016247857,0.011252383,0.09424948,-0.022877578,0.06530423,0.003695797,-0.0033495834,0.00397798,-0.0014257843,0.09070377,0.020632943,-0.0064048483,0.025909549,-0.022057125,-0.027792914,0.06881927,0.038458817,0.035050754,-0.03163155,0.03117447,-0.029888257,-0.0475663,-0.05878555,0.017518934,-0.039748155,0.019400677,0.009859927,0.042287353,0.087530896,0.032728557,-0.036071856,0.057872817,0.030624775,0.016550623,-0.12992018,0.02941936,0.03130764,-0.06165472,0.0060043833,0.048913993,-0.035747986,0.039059255,0.03294492,0.047639318,-0.042057514,0.07841724,0.00891672,0.01694076,-0.046240475,-0.055774275,-0.012464416,0.06864302,0.05125529,0.09454834,0.03923746,0.063731186,0.030972233,-0.023178449,0.046287585,0.055247616,0.013120482,0.036310203,-0.025905825,-0.06252857,-0.119148195,-0.030249055,-0.008542686,-0.023537131,0.06768978,-0.026016884,-0.024560405,-0.02056245,0.03285648,-0.04007277,-0.007883578,0.042934217,-0.043543454,-0.04549613,0.041724052,-0.04947929,-0.06658736,0.042866226,0.016864307,-3.997447e-08,0.04235917,-0.043661036,0.058146257,-0.08287739,0.06518126,-0.0045242286,0.010925042,-0.0015462281,0.047752064,0.03513698,0.03266777,0.08298909,0.019471815,0.030303383,0.089757025,-0.013588516,-0.06828865,0.0664368,-0.038574837,0.0791236,-0.041267097,-0.05509515,-0.14489596,0.040133838,0.012422833,-0.008985902,0.06404612,0.01902125,0.03291468,-0.06125432,0.00270625,0.025073286,0.059573986,0.032161314,-0.12104954,-0.04701559,-0.04089769,0.012951637,-0.058988843,0.031850565,0.0005829228,-0.03485946,-0.0751048,0.00886272,-0.0054466915,0.021512404,0.04299661,-0.03971545,-0.03632066,-0.016118864,0.02735148,-0.02051817,-0.007616246,-0.065783724,-0.08136364,-0.034026694,0.05372993,-0.034929886,-0.025665818,-0.040057965,0.038438354,0.0075335307,0.16456333,-0.044717703 +1.2.99.9,The enzyme from methanogenic archaea is a involved in formate-dependent H2 production. It contains noncovalently bound FAD [1]. ,384,1.0,-0.06172024,-0.036345188,-0.06965393,-0.025659222,0.09999013,-0.01869063,-0.11629221,0.03590881,0.018317606,-0.013248527,-0.051744364,-0.033633336,-0.07857549,-7.523495e-05,-0.057842582,-0.016405413,-0.07289722,-0.03915184,-0.00059763336,-0.0042652288,0.09031289,0.102467135,-0.021099957,0.005932066,-0.003955405,-0.00996674,0.055783894,-0.05200647,-3.1834676e-05,-0.047331367,0.032095637,-0.05057137,0.09630134,-0.018110821,0.08186402,0.082584105,0.063896224,-0.0547001,0.030519832,-0.055116285,0.076651834,0.017334219,0.0680151,-0.0072714672,0.0019626918,0.022970868,0.08178625,-0.013138021,-0.03230434,-0.05874325,-0.023011228,-0.071226075,-0.079095885,-0.012159762,0.039932396,0.113810785,-0.0104720425,-0.055965874,0.01432732,-0.009491218,-0.0063707293,0.013068706,0.03383908,-0.042220157,0.054871753,-0.043842897,0.044821758,-0.04325675,0.050240446,-0.021731725,-0.036785368,0.004637885,-0.039998636,-0.06944658,0.00083627645,0.029860346,-0.021251282,-0.07888854,0.07504095,-0.055695523,0.005313904,-0.018954562,0.093061194,0.050438985,0.014297229,-0.05349938,0.045721263,-0.021451645,0.025536211,-0.036366142,-0.02678621,-0.020667916,0.024210546,-0.043917257,-0.09553278,0.050772615,0.105968334,0.049961258,0.027546491,-0.011823853,-0.016602235,0.03218367,-0.034816615,-0.060582574,-0.058412336,-0.09979305,0.025748761,0.16228561,0.01806644,0.06690595,0.075642124,-0.006830252,0.038334265,0.0012990672,0.0030778525,0.019103717,0.0005748371,-0.08613828,-0.048814084,-0.019498179,-0.03530798,0.02589018,0.08229356,0.032271616,-0.011475237,-0.017389558,-0.06513959,1.418514e-34,0.08580781,-0.054834597,-0.028250223,-0.021160105,-0.01930429,-0.021853112,-0.16647775,-0.039250314,0.024189591,0.013081853,-0.0298895,-0.050745774,0.03639592,-0.03322846,-0.027090253,-0.006523767,-0.0042170556,-0.0068322346,0.013960288,0.04382601,-0.06577884,0.0504922,0.002341396,0.009997738,0.051893756,-0.051445566,0.003697912,-0.008125832,0.08095519,-0.0012155136,-0.0044298097,-0.09442498,-0.08295678,-0.0025002286,0.03200216,0.05727059,-0.11646072,-0.020082163,-0.08437004,0.035841603,0.044577915,0.065919995,0.056496173,-0.06139935,0.073064096,-0.007658504,0.010251755,0.10175637,-0.010317739,0.0516671,-0.04148341,0.014387312,0.078818515,0.0023922275,-0.056562535,-0.04510298,0.0002692099,-0.015301052,0.08695695,0.04476591,-0.029105306,0.061917048,0.009984279,0.13236865,-0.065268695,0.02998765,-0.0029496162,-0.02505287,0.063389875,0.14189383,0.0048754993,-0.025384387,0.061253063,0.03563402,0.018577611,-0.103210576,0.017568229,-0.08169464,0.07470618,0.007843278,0.020615328,-0.065666944,0.038138114,-0.044763025,-0.06126734,-0.01712011,-0.0874705,0.004657528,-0.003374934,0.080803014,0.020221509,-0.07216036,-0.0067746337,0.013603965,0.023148842,-6.654146e-34,0.037381794,-0.07190165,0.0429249,-0.101010494,-0.055663638,0.090361595,-0.027385289,-0.0043387837,0.041994408,-0.060672957,0.1079336,0.002771816,0.00028744823,-0.050427556,0.019510677,-0.029214118,-0.045037873,0.040531393,0.07286342,0.048466712,0.061227296,0.0057070516,0.005701985,0.01945145,0.058587793,0.0020232876,-0.0061230226,0.078805484,0.0055635907,0.03704824,0.004712495,0.005322857,-0.04477106,-0.03696976,-0.1424306,-0.04502017,-0.0022598554,-0.005520539,-0.03418313,-0.03807687,0.039298218,0.06656642,0.007263962,0.098965794,0.02184582,0.04735937,-0.07161482,0.041322105,0.05815389,-0.04599373,-0.028996339,-0.08304018,-0.013268207,-0.06288743,-0.006901994,0.042466253,-0.015132643,0.07670646,-0.029982178,0.008224417,-0.011951382,-0.07661508,0.066549264,-0.023706418,0.060213827,-0.016465923,-0.0007089553,0.069424875,-0.008421062,0.055201862,0.0795248,0.026480207,0.024748845,0.06851756,0.029249515,-0.049794897,-0.03912458,-0.005173386,0.0789925,-0.012515487,0.019806884,0.063298985,0.0073496294,0.0025319064,-0.0023413384,-0.066295534,0.06745857,0.055929817,-0.061157677,0.03623273,-0.032553174,0.019711796,-0.022917887,0.007489709,0.005886937,-2.5815211e-08,0.055005655,-0.07419322,0.08490352,-0.027787799,-0.024972493,0.08230421,0.023004306,0.008350775,0.062077217,0.019385409,-0.035104845,0.07502236,0.0004559114,-0.038259275,-0.01570002,0.064750835,-0.05132404,-0.004471045,-0.09860142,-0.02714121,-0.03047916,0.0066097286,-0.0307666,0.018162573,-0.007700217,-0.030534467,0.02792471,0.051309064,-0.06444056,-0.071745485,0.0107428925,-0.00035880986,0.039207652,-0.021883888,-0.07761157,0.018533895,0.004819916,-0.015179643,-0.037907086,0.019174384,-0.019042628,0.024003793,-0.035078004,-0.0014942205,0.01788073,-0.012954905,-0.037167095,0.03801575,-0.06648944,-0.006564327,0.040937006,-0.0013430981,0.057445657,-0.08554781,-0.07734537,-0.031203652,-0.0044134473,-0.04470994,-0.041818406,-0.0071779317,0.1368287,-0.034479965,0.09339004,-0.01245737 +1.3.1.107,"The enzyme, purified from the California poppy (Eschscholzia californica), is involved in detoxifying the phytoalexin sanguinarine produced by poppy itself (cf. EC 1.5.3.12, dihydrobenzophenanthridine oxidase), when it binds to the cell wall of the poppy cell. The reaction with NADPH is up to three times faster than that with NADH at low concentrations (<10 uM) of the dinucleotide. At higher concentrations the reaction with NADPH is inhibited but not that with NADH [1].",384,1.0,-0.06820439,-0.017962335,-0.06204731,-0.013156805,0.039593097,0.05124464,-0.02278927,0.0034706446,0.08677252,-0.0028295899,0.015542424,0.03537614,0.006957917,0.019606626,-0.05428291,0.041864097,-0.08963518,-0.010056116,-0.014837004,-0.023263175,0.04842007,-0.0045511117,0.037138145,-0.004956874,0.06081758,0.039393965,-0.029430356,0.00032285036,0.002545315,-0.049735405,0.04247742,0.023924252,-0.009979537,-0.037845008,-0.095134914,0.080937795,-0.07587968,-0.02712243,0.07443752,0.012418155,0.058729317,0.0050819633,-0.09028148,0.043450814,-0.011748098,-0.0355253,-0.03725247,0.021366501,0.054248273,-0.04174769,-0.01003061,-0.06118216,0.049176972,0.046300307,0.010829754,-0.019173028,0.08959449,0.07106968,0.028405348,0.022390308,-0.020043792,0.033438317,0.015578477,-0.025459593,0.028620483,-0.05278643,-0.040588822,-0.026514795,0.02009772,-0.07254365,-0.07531974,0.03764774,0.039301872,-0.021138582,-0.023794051,0.004858908,-0.046338063,-0.0049480214,-0.03302372,0.004666547,0.049532324,-0.016558869,-0.033839423,0.117371075,0.08045797,0.021599669,-0.031243078,0.022340706,0.017554497,-0.001990826,0.05641461,0.021454768,-0.00988572,0.037591826,-0.0679327,0.013492412,0.07535858,-0.046459623,-0.08116387,0.0009250705,-0.03557408,0.077568576,-0.117476225,-0.116566,-0.07972896,-0.0044380403,-0.031524036,0.032451097,-0.074548475,0.016762177,0.020306304,-0.038850516,0.0066080983,0.075555734,-0.11573036,0.08209676,-0.0011046296,-0.038028367,-0.049472153,-0.059597973,-0.011128709,-0.032278597,0.055911083,0.0041861855,0.018918151,0.020650936,-0.024703965,3.2342496e-33,0.05356144,0.0568326,-0.061427724,0.04842103,0.05017218,-0.043602403,-0.013415575,0.03529539,0.053155538,-0.10707039,-0.050178528,-0.078775,-0.025450012,0.0039685224,-0.008723486,0.0059179463,-0.05825183,-0.06392168,-0.015958875,-0.036524486,0.047363907,-0.021823756,-0.053018764,0.003204161,0.009951314,0.014873408,-0.12206355,0.0072801155,0.05851847,0.026316911,0.053408124,-0.035690453,-0.11195556,0.018350236,0.10290484,0.028837765,-0.034575973,-0.07666018,-0.04958485,0.045114473,-0.06871308,0.0202616,0.063915685,0.00038178565,0.051951427,-0.04793959,-0.0616759,0.05146459,0.08420019,0.037511148,0.048313197,-0.006156013,0.11285711,-0.058791243,-0.009933892,0.012930738,0.03750858,-0.101837285,0.005630483,0.07586724,0.047914363,0.03568971,-0.05215996,0.01578334,-0.023282962,0.0567494,-0.09899423,-0.0037633954,0.012798104,0.04686468,0.013217447,-0.008226215,-0.013307351,0.0008214876,-0.02305975,0.031606417,0.017875602,0.047792856,0.032375615,-0.039546996,0.05252824,-0.13128372,-0.065047204,-0.01855608,-0.011460268,0.048679296,0.030501531,-0.016700815,-0.016609441,0.023250485,0.07372939,-0.034188103,-0.031997457,-0.1320774,-0.02155818,-2.769309e-33,0.07400577,0.0007745635,0.04794328,-0.020313306,0.009711913,0.03985141,-0.0024883137,0.040147167,0.047612064,-0.0077363593,-0.030031277,0.06493259,0.03400302,0.011449075,-0.011719598,0.03681833,0.04631731,0.08488567,-0.08035873,-0.075611345,-0.0753853,0.07601991,0.00948581,0.028643671,0.041334547,-0.031980094,-0.010497865,0.09431746,0.076207906,-0.015897145,0.0017340214,-0.026420133,-0.07214541,-0.014733222,0.01605388,0.055393167,-0.02184306,-0.013349988,0.031666204,0.08590467,-0.04042242,-0.101227246,-0.074439295,0.027879158,0.04203275,0.041330475,-0.13287665,0.052496348,0.07719661,-0.056034572,0.104892835,0.0605871,0.04639662,0.06559181,0.059729293,-0.023970844,-0.0049104686,0.0027616501,-0.019804318,-0.07889408,0.021873916,0.0007865908,-0.056687903,-0.0032187684,0.03304904,-0.05166988,-0.050946083,0.09262982,0.053830184,0.01461662,0.020451674,-0.0019375331,0.018351916,-0.0149256345,-0.08528761,-0.042782348,-0.08121634,-0.016588239,0.06751258,-0.025640257,0.01967934,0.051648427,0.0007668169,-0.11585268,-0.0053663184,0.013121829,0.021886177,0.047367007,0.000971997,-0.013073832,-0.0020553882,0.0061615845,-0.05436697,0.05057424,0.09399034,-4.358654e-08,0.07673689,-0.028809758,0.022558028,-0.039066352,0.0027583097,0.012724341,0.041858576,0.031390626,0.0134727135,-0.039261397,-0.0512735,0.10441628,0.043560848,0.06451416,-0.016085729,0.011696938,-0.025494624,0.03787332,-0.04309149,-0.0337041,-0.031393267,0.022215439,-0.10637294,0.018203195,-0.0054735816,-0.025143119,0.027938046,-0.035726257,-0.0039715674,-0.05447552,0.057869222,-0.0069915866,0.009932007,-0.044635285,-0.11275177,0.07469121,-0.008265446,-0.01427582,-0.017291885,0.020610925,0.012967579,-0.017548949,-0.0854592,0.023598224,-0.02447255,5.0419185e-05,0.03898913,-0.0051821047,-0.05178864,-0.0016690077,0.09875241,0.036903083,0.0009458514,-0.0054106275,-0.12707388,-0.031331573,-0.03952035,-0.034002163,0.010123575,-0.0617321,-0.004676046,0.017451799,0.23532678,0.049135562 +1.3.4.1,"The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)] and EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)].",384,1.0,-0.060142413,0.052791264,-0.15367582,0.017896898,0.085421436,0.012126016,-0.10621584,0.039063677,0.0037634715,-0.025328519,-0.031114286,-0.098314606,-0.08405239,-0.02374752,-0.060859345,0.022748841,0.0050911065,-0.009038523,-0.0037733642,0.017369183,0.06661426,0.057380624,0.0034092304,-0.026364798,0.03214315,-0.015387554,0.01035529,0.01700326,-0.04045812,-0.06301613,0.02396043,-0.06275657,0.100028045,-0.06013493,0.049187057,0.10708488,-0.046410713,-0.095559694,0.019100357,0.041982386,0.00887685,0.02318684,0.033555668,-0.009988867,-0.05684522,-0.02060242,0.018142782,0.01727153,0.0408775,0.014115426,-0.037726592,-0.057182018,-0.055564057,0.011789454,0.02196224,0.04263202,-0.012936999,-0.029258054,-0.066098504,-0.08023747,0.04225281,0.023638442,0.010566868,0.025554348,-0.0027194112,-0.0056110346,0.010008458,-0.08826962,0.049640946,-0.058451124,-0.02201996,-0.004546089,0.010758455,-0.0069015524,-0.07223609,0.049101055,-0.022911588,-0.058885366,0.08579836,0.0050835386,0.028066255,-0.096018806,-0.02022797,0.021488154,0.056917563,0.017880548,0.012914373,-0.014457601,-0.015160479,-0.0061772824,0.039658923,-0.0004532215,0.02198504,-0.031805065,-0.109881505,0.029149974,0.07067133,0.11272164,-0.03156754,-0.014354352,-0.002834501,0.098003976,-0.022727262,-0.08678713,-0.11245364,-0.0072884266,0.040363967,0.06478509,0.029331574,0.028695965,0.0042895046,-0.047386095,0.05177391,-0.035020474,-0.027077332,0.08473658,0.0065763076,-0.09302884,-0.0965737,0.025794134,-0.010321399,-0.014496339,0.13012636,0.028420264,0.032398622,0.025491353,-0.12782586,4.5910556e-33,0.093488365,-0.006322618,-0.0325311,-0.046530925,0.01878696,-0.013092226,-0.08643378,0.022711216,-0.07704256,-0.01034041,-0.06444092,0.0054609077,0.10166717,-0.057679273,0.01647367,0.019623537,0.022025835,-0.08540914,0.0028032688,0.01924262,0.016917476,0.018662924,0.011214892,0.030428644,0.026101122,-0.013017918,-0.0072283926,0.03745728,0.02008813,0.030633992,-0.005480031,-0.12910122,-0.12730628,0.008024379,0.036616117,0.011963257,-0.11074439,-0.023935016,-0.072986834,-0.003080111,0.014771243,0.04499493,0.046096563,-0.029912587,0.13699768,-0.015038989,0.006245492,0.13145739,0.05691193,0.07235115,0.0112402085,0.0035586949,0.07808642,-0.02471708,-0.045656428,0.004157917,0.004163077,0.052333724,0.01809994,0.082771964,-0.0126590375,0.062393773,-0.02012973,0.0868061,-0.0269035,0.054661676,-0.05117667,-0.020708477,0.021085398,0.034910057,-0.0052416134,-0.025819164,-0.0012424409,0.013370794,-0.012268159,-0.019236477,0.058231965,-0.028095182,0.02506571,-0.05487233,0.018540919,-0.007504694,0.016953038,-0.007391357,-0.032610957,0.024098782,-0.029504942,0.031927172,-0.013022585,0.07977603,0.078299776,-0.09498966,-0.042041738,-0.07038046,0.031662796,-3.7606393e-33,0.047462676,-0.05326248,0.0043244865,-0.10890856,-0.030064564,0.1326074,0.02914774,-0.014810433,0.03682736,-0.05885269,0.0964944,0.00518726,0.06443178,-0.11138782,0.08327384,0.007039269,-0.030239874,0.036526095,0.03000108,-0.01053616,0.04708184,0.08655786,-0.008117103,-0.054796305,0.020717857,-0.009191049,-0.038837653,0.018454555,0.0514761,0.008090291,-0.04565573,0.0578477,-0.057548083,-0.033169553,-0.0792575,0.0057601477,-0.0651733,-0.012209257,0.046209067,0.051397864,-0.015524157,0.05510393,-0.029886518,0.030251523,0.07097475,0.06632244,-0.13573158,-0.05126087,0.02782211,-0.0040752776,0.0136079,-0.08395819,-0.047187086,-0.0054010083,0.04105486,0.013002158,-0.008986347,0.0439711,-0.011800583,-0.014499965,0.037206843,-0.056760933,0.04243144,0.03603041,0.03806698,0.05713397,0.025839081,0.08884271,-0.017305866,0.031343862,0.083772235,-0.006283206,0.0018392317,0.09344149,0.029745286,-0.022441681,-0.03919739,0.06175179,-0.014769318,-0.01749651,0.01751211,0.020793822,0.049855124,-0.08923118,0.076496854,-0.042159922,0.025001237,-0.025468007,-0.028661214,0.05396194,-0.048762556,0.011667633,-0.018453421,0.00028894417,0.035490163,-4.297815e-08,0.02851994,0.00032708238,0.08256434,-0.045960035,0.044722114,0.03953213,0.010612297,-0.020410163,0.010688586,0.021619985,-0.006282951,0.074795745,0.052141253,0.009454061,0.031833176,-0.0066611143,-0.015951544,-0.00096715306,-0.05408353,0.0046513816,-0.009740229,0.0018735769,-0.084960364,0.04417026,0.024835937,-0.023614187,0.013626753,-0.046038408,0.019104848,-0.056911763,-0.03608219,0.009391384,0.05595355,-0.054742914,-0.15149179,0.016266044,-0.0009884888,0.004847596,-0.12406137,0.042377602,-0.0025778266,-0.068220645,-0.03144994,0.03676217,0.02565168,-0.010743453,0.04490383,2.4160956e-05,-0.039472535,0.026052296,0.05239979,-0.044227086,0.010437818,-0.06226313,-0.11650985,-0.009812353,-0.0038386541,-0.012067577,-0.04318971,-0.058227435,0.06914839,-0.03937331,0.12787642,0.003543263 +1.5.99.15,"This archaeal enzyme catalyses the last step in the biosynthesis of tetrahydromethanopterin, a folate analogue used in methanogenesis. The enzyme, characterized from the archaea Methanosarcina mazei and Methanocaldococcus jannaschii, is an iron-sulfur flavoprotein. cf. EC 1.5.1.47, dihydromethanopterin reductase [NAD(P)+].",384,1.0,-0.037339523,0.014165514,-0.18537883,-0.017655876,0.093143284,-0.0016494443,-0.08680285,0.02549735,0.022145662,-0.025800047,-0.059876375,-0.061360795,-0.07664923,-0.02815239,-0.09537,0.054195937,-0.07228496,0.00797638,-0.005747415,-0.024374392,-0.005472744,0.06261836,-0.015286523,-0.01768187,-0.054718442,-0.02143076,0.03269588,-0.02685497,-0.063666485,0.005006711,0.015876776,0.014098366,0.028989688,-0.052232597,0.018913124,0.12710194,-0.063385546,-0.045233384,0.023238713,-0.015637537,0.040690135,-0.035027202,0.034771163,-0.010847028,-0.025388556,-0.0443342,-0.010858797,0.03682617,0.051864114,-0.006046296,-0.085622616,-0.057213526,-0.053857576,0.046813536,0.08710599,-0.0018239061,0.049178228,-0.06232734,-0.011718729,-0.013161615,0.039550878,-0.02775471,-0.0057800035,-0.04013544,0.03625177,-0.01391023,0.04314289,-0.11929067,0.07163337,-0.038959507,-0.04322292,0.032026008,-0.026363354,0.015843092,-0.028129624,0.051140025,-0.010034236,0.012876325,0.060529537,0.00388521,0.038047057,0.027385596,0.019124493,0.06704413,0.11219934,-0.020682553,-0.0647418,-0.012053073,0.05878848,0.023520013,0.003584591,0.0032915093,-0.013758913,-0.013419238,-0.10984049,-0.04199772,0.05729369,-0.03030883,-0.025041495,0.0035765045,-0.06340335,0.026038965,-0.052789763,-0.054787498,-0.07522795,-0.031088155,-0.006402312,0.15010774,-0.010202655,0.04817111,0.013029648,-0.058478743,0.113004915,0.022149159,0.0038748882,0.08532144,-0.019240653,-0.07176875,-0.021005817,0.05474564,0.025002768,0.038486708,0.07208283,0.05565479,-0.03020766,-0.041898176,-0.15520199,4.1564966e-33,0.10036943,0.056268096,0.007618783,-0.00026717212,0.06691408,0.0029658787,-0.0870477,0.042638093,0.05565869,-0.040470976,-0.07011564,-0.08085519,0.042894393,-0.020748725,-0.017153962,-0.06890898,-0.0034230337,-0.03454281,0.038076557,0.0002727568,-0.009894502,0.07683126,-0.010803819,-0.012517819,0.051983453,0.07539031,-0.015856266,0.017189236,0.016018428,0.028754722,0.070960395,-0.106600195,-0.13944773,-0.023780216,0.06566872,0.0058968733,-0.048120156,-0.026269676,-0.05425745,0.07686412,-0.026662337,-0.009473068,0.022909774,-0.044938967,0.032481033,-0.00023732703,-0.011708216,0.079105206,0.060626764,0.010531435,0.033842724,-0.003997545,0.06532149,-0.009622838,-0.14145975,-0.03510652,-0.06945327,-0.025351146,0.047595676,0.081851184,0.0033020477,0.0046534105,-0.001248767,0.09638005,-0.07728738,-0.017966745,-0.03769663,-0.08923675,0.04927252,0.06639084,0.044818666,0.02655571,0.110897556,0.021458995,0.021336347,-0.014701713,0.014769424,0.003651326,0.00086626696,-0.03172427,0.024775703,-0.024076298,-0.030015336,-0.0019213051,-0.052761335,0.048534904,-0.040923666,0.006785838,-0.01396268,0.024119051,0.022246748,-0.07410267,-0.060712382,-0.009906397,0.022836694,-4.019822e-33,0.058515415,-0.10711304,0.040685013,-0.123416565,-0.029820789,0.07921379,-0.03423657,-0.025980476,0.023381745,-0.03815659,0.09407544,-0.016517129,0.046481226,-0.035747223,0.020192608,-0.0022125875,0.012399329,0.038421787,0.041164745,-0.030507894,0.043845244,0.025645474,-0.07667985,-0.08614462,0.057774626,-0.012505076,-0.013779652,0.07468379,0.029261738,0.053569973,-0.01730916,0.028865581,-0.045385536,-0.06491178,-0.050575603,0.079077326,-0.06014794,-0.040936213,0.020793725,0.039007086,0.05614427,0.05216616,0.026575215,0.041184228,0.056771226,0.0639295,-0.07845423,0.034799986,0.09216978,-0.03089032,0.061702624,-0.025757441,-0.0064512994,-0.0052671432,0.03624921,0.08049086,0.015144576,0.02177703,0.00022143692,-0.007354498,-0.004940958,-0.06482398,0.06755231,0.009986935,0.032577984,0.035789542,0.007755758,0.058803026,0.039555162,0.042953018,0.0841631,0.026052605,0.04144718,0.10247663,0.0061187134,-0.059157554,-0.018942336,0.07533126,-0.009364564,0.010668091,-0.0091163125,-0.06672505,0.08133174,-0.011853069,-0.011528607,-0.079751484,0.08150917,0.046733093,-0.027728759,-0.0056886855,-0.011717765,-0.010296854,-0.06709697,0.013103667,0.037792157,-3.7791615e-08,0.050293256,-0.09239544,-0.03317434,-0.06285857,0.014628937,0.03866564,0.07887207,-0.01074789,-0.051700316,-0.041582663,-0.023262894,0.10675843,-0.004440541,-0.0039313366,-0.0049547716,0.06646177,-0.026803996,0.017690493,-0.005879894,0.030305052,-0.0057155667,-0.0052306126,-0.083320335,-0.009322098,-0.027204456,-0.04442938,0.011394312,-0.0075934073,0.0023038045,-0.09224506,-0.0124175735,0.06604947,0.051280674,-0.022715108,-0.124719925,0.03805294,-0.067402735,-0.041297354,-0.03926517,0.021800432,0.008032931,0.0071629332,-0.032671373,-0.016843783,-0.0035468042,-0.040252913,0.008157299,0.0371589,-0.050478075,-0.04158615,0.026931508,0.050533447,0.049829952,-0.019023553,-0.046426706,-0.0014357028,-0.019454705,-0.028581508,-0.037571207,-0.0057304273,0.101216815,0.013464572,0.12261434,-0.044145335 +1.8.98.3,"The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, is involved in sulfite detoxification and assimilation.",384,0.99999994,-0.09062797,-0.031553634,-0.09245437,0.020913867,0.06893077,0.02100467,-0.051082138,-0.003023757,0.006802562,-0.046726167,-0.020250468,-0.013670894,-0.07070263,0.03015287,-0.11758083,0.07543465,-0.07574708,0.047534443,-0.0020589973,0.016411861,0.079431035,0.07784724,-0.07464463,-0.016601184,0.10317265,0.02077848,0.0043478445,-0.048358634,-0.039668337,-0.0038008157,0.02041534,0.0034423273,0.07275066,-0.05569018,0.061048795,0.12506491,-0.03947165,-0.08062236,0.0503829,-0.02275733,0.018005723,0.043222956,0.049606573,-0.075055934,-0.008224686,-0.01200093,-0.028203575,0.012931133,0.110774815,-0.09205652,-0.070622295,-0.06477206,-0.100189134,0.018355101,0.05713042,0.0347482,-0.028603958,-0.055360578,-0.00092842913,-0.023584204,0.026809894,0.08609667,0.023232494,-0.0074002612,0.054949712,-0.032169938,0.038754657,-0.03108627,0.08916235,-0.09691139,-0.07174248,0.013218835,-0.035829682,0.0062952414,-0.049378715,0.01710197,0.019483393,-0.043533582,0.01970077,-0.027792532,0.026961297,0.01189469,0.021583205,-0.0023171136,-0.026716579,-0.021042613,0.01666673,-0.011425801,0.080347046,-0.046749223,-0.0010554108,-0.02231968,-0.01994775,-0.09315771,-0.023702728,-0.07810118,0.038241014,0.12185124,-0.035602625,0.032496464,0.028819457,0.03810194,-0.030231744,-0.127333,-0.034212008,-0.01068457,0.021309229,0.07991037,-0.0022248584,0.07242281,0.027958252,0.006346726,0.054129146,0.0066851377,0.022461077,0.088529244,0.05527195,-0.06473937,-0.11069769,0.06346491,-0.06013567,-0.04353117,0.07585832,-0.04235752,0.012490246,0.04426648,-0.05055185,1.8441709e-34,0.06951961,0.003218953,0.027120912,-0.020676674,-8.629378e-05,-0.061192356,-0.059001796,0.04182347,0.0526674,-0.024398543,-0.092387386,-0.009145409,-0.006766899,-0.0001607217,-0.054870617,0.018509861,0.008907513,-0.032473315,0.02212081,-0.03566504,-0.0011970797,0.011803528,-0.006968779,-0.036906794,0.02871246,-0.03300525,0.024626443,0.0072338986,-0.022989783,0.00017326375,0.06675583,-0.0939193,-0.08799766,0.011338304,0.08536867,0.022152148,-0.023610549,-0.061633624,-0.04257496,-0.01231941,0.012380381,0.039479144,0.033235747,-0.06409704,0.052375328,-0.018765258,-0.0679188,0.09306347,0.092932686,0.0033605667,-0.023448471,-0.040413532,0.03560993,-0.02107192,-0.0725979,-0.050079223,0.038956564,-0.054573677,0.07725107,0.06359873,-0.061098184,0.024581641,-0.06374962,0.03440146,0.024307882,0.04916998,-0.07742139,0.02982371,0.03261961,0.0671604,-0.063943274,-0.037182845,-0.064377055,0.04828683,-0.054210335,-0.054251447,0.042844202,0.014285651,0.006845365,-0.0076425844,0.009768587,-0.046129122,-0.06360098,0.030295935,-0.07280034,0.0369035,0.015802251,0.027943559,-0.028396964,0.043480393,0.027313784,-0.012430094,-0.10457015,0.019277532,0.019112004,-2.0238005e-33,0.1006424,-0.0937109,-0.015160337,-0.12589045,-0.0466303,0.08226675,0.04461099,0.07806563,0.036264893,-0.05536573,0.014475849,0.046868216,0.09722252,-0.028076876,0.01921167,-0.01933303,0.079312466,0.04143276,-0.0075378437,0.05858721,0.013646255,0.10338357,0.026282152,-0.072720826,0.04911514,-0.04022882,-0.013043812,0.058242433,-0.008927993,0.040080708,0.03385057,0.026702601,-0.028399229,-0.08978702,-0.09866308,0.03434082,-0.044719353,-0.033011325,0.035787184,0.020206694,0.013564719,0.011677148,-0.0380772,0.11008938,0.05245965,0.026505256,-0.07923891,-0.019497918,-0.024810119,-0.055112023,0.076690376,-0.044424217,0.07310005,0.0015393802,0.016890815,0.029951919,-0.0115959635,0.016491614,-0.0406253,-0.027195957,-0.035209883,-0.014848711,0.018926505,-0.10632148,-0.00092835503,0.040897693,-0.027512403,0.008015702,-0.006062625,-0.030617148,0.008743961,-0.02711682,0.0047958214,0.026996443,-0.07862933,-0.036925543,-0.118851006,0.08791297,0.028878944,0.013617603,-0.018123543,0.0020065873,0.059083976,-0.051072665,0.034766763,-0.058543265,0.030481463,0.059453804,0.04465021,0.013904121,-0.041359197,-0.01575245,-0.09364458,-0.004532161,-0.021305567,-2.5924868e-08,0.0052297036,0.012154131,0.058821946,0.056041714,-0.075864345,0.048622895,0.088357225,0.021979662,-0.023436898,0.057616606,0.032351743,0.1355895,-0.026410157,-0.022128193,-0.012119639,0.039811857,-0.08475612,0.02900324,-0.044192582,0.020182716,0.043814063,-0.044486947,-0.029280389,0.05678752,0.06743899,-0.034617953,0.0734668,0.003987893,-0.048010778,-0.042680845,0.021284739,0.013511459,-0.022242522,-0.056556977,-0.06013662,0.043933764,-0.0005642153,-0.028737266,-0.023845898,-0.021967793,0.019007621,0.05616329,-0.08844701,0.006354255,-0.029021583,0.01937471,0.004674575,0.05275913,-0.03837217,-0.0046910685,0.120842,-0.021464707,0.0040815137,-0.039906837,-0.081676885,-0.01620257,0.043786053,-0.019502096,-0.049043987,0.0318761,0.084953085,-0.022877077,0.12111282,0.013631247 +1.14.11.47,"The enzyme, characterized from the bacterium Escherichia coli, hydroxylates an arginine residue on the 50S ribosomal protein L16, and is involved in regulation of bacterial ribosome assembly.",384,1.0,-0.01568358,-0.052713063,-0.09463274,-0.044333845,0.0072985827,0.035951626,-0.016274378,0.01941046,0.0126896845,-0.030045047,0.027982943,0.018373126,0.02817617,0.11591044,-0.08551886,0.05716253,-0.07135868,-0.01036389,-0.010667273,-0.037031837,0.055474527,0.06911855,-0.09908907,0.02112514,0.023990907,-0.02070612,0.051823214,-0.00833682,-0.02575633,-0.0581518,0.031230582,0.036060564,0.06782734,-0.06869437,0.04341897,0.060436796,0.009924436,-0.102614395,0.13962214,-0.004321367,0.02591945,0.017242454,0.019044258,-0.030125538,0.015332243,0.044062104,0.07901106,0.13401426,0.061702263,0.011936239,-0.03925532,-0.03372451,-0.051512685,-0.011090213,0.0009870969,0.025476443,-0.05861098,-0.10832786,0.023121992,0.03659934,-0.008417494,-0.018770276,-0.017948966,0.040079072,-0.0020572136,-0.13697495,0.09650817,-0.016118523,0.020669617,0.0069601913,-0.009856724,-0.059125256,-0.037362166,0.06972465,-0.016758509,-0.040943507,-0.0039272285,-0.042536955,0.07217388,-0.027261619,-0.043183673,-0.054423004,0.04296077,0.11203227,-0.0006779025,-0.014169375,0.008619178,0.0063653,0.056550745,0.040883824,0.024279745,-0.068148,-0.006252781,-0.018394519,0.0035597759,-0.029484086,0.024522075,0.011194921,-0.0073643145,-0.034204435,-0.00085010176,0.06404004,0.011103818,-0.067477725,0.011942352,-0.008618383,0.0592599,0.13695255,-0.034112364,-0.0044217655,-0.010498905,0.037790254,0.016040053,-0.019325309,0.0071465536,0.05952318,0.08694989,-0.09703004,-0.08034296,-0.034897376,-0.021242203,0.0059394636,0.042493653,0.07841618,-0.09031052,0.023334518,-0.075075276,7.870751e-34,0.03760637,-0.014526992,0.013443193,0.011265549,-0.012251393,-0.0031148419,-0.061972655,-0.010302157,-0.019762654,-0.041625008,-0.125498,-0.061304443,0.062660605,0.0040655867,-0.037353314,-0.059265383,-0.038914952,0.018759323,-0.0014645456,0.03312429,-0.05893602,0.06286855,0.0009591008,0.026680851,0.003365468,0.05048634,0.033901185,-0.011784209,0.04660291,0.014254255,-0.02528602,-0.022055874,-0.102176465,0.037246123,0.021566998,-0.017962376,0.02419398,-0.027594833,0.078851275,0.061319385,0.007988668,0.035630237,-0.017573088,-0.06942753,0.051706016,-0.011153928,0.018249735,0.08599946,-0.018467914,0.053923033,0.054012027,-0.007972295,0.066652045,-0.120551914,-0.061769325,0.027484767,-0.022496996,0.03757358,0.009231632,0.017193057,-0.0066886027,0.039243545,-0.030416057,0.11640084,0.015245029,0.008706631,0.015068732,-0.11738096,-0.024317114,0.09038324,-0.076843455,-0.000831247,0.13865484,-0.017772423,-0.024852108,-0.045872457,-0.11412448,-0.027203409,0.039349306,0.06333586,-0.029352495,-0.031890944,0.011297785,-0.02651199,-0.02551054,-0.005761458,0.069189705,-0.006315271,0.011514201,0.012585259,0.074563,-0.04900216,-0.024746694,0.036572874,0.023208722,-2.5513356e-33,0.1011964,-0.14384273,0.03769661,-0.026752215,-0.092732355,0.023199134,0.04699637,-0.030658962,0.059298884,-0.023707198,0.066329055,-0.0041023227,-0.032437287,-0.07493141,-0.006853327,-0.031795166,-0.027957618,0.01584989,-0.05063725,0.009131415,-0.017230842,-0.0031513164,0.016770333,-0.0068874955,-0.027630072,0.01269513,-0.022939546,0.01641828,0.011359187,0.03910338,-0.03719402,-0.06939265,0.030761287,-0.04242967,-0.048920594,0.09919088,-0.007558786,0.030538658,0.02554954,-0.09998659,0.0066084038,0.07469908,-0.020155162,0.07145082,0.03354607,0.062370308,-0.015026528,-0.011263045,-0.07498298,-0.12838267,0.03144407,-0.04941484,0.10643923,0.04132727,-0.05232462,-0.006598284,-0.033386946,0.039810225,0.01029342,-0.008981155,0.002736024,-0.053929266,-0.013712836,-0.013843144,0.029090783,0.035161134,-0.0720516,-0.024866795,-0.011918032,-0.014958111,0.051020395,-0.010869511,-0.013375331,0.059677575,0.0480427,-0.050324727,-0.08683315,-0.09065016,-0.058805156,-0.032132152,-0.0047484967,0.012012371,-0.076322,-0.012198135,0.017097563,-0.08537631,-0.0096103605,0.13377947,0.021461895,0.04651294,-0.0064895796,-0.0013356452,-0.049588136,0.032266866,0.07310133,-3.0409872e-08,0.017231947,-0.0053668306,0.015740633,-0.048059337,-0.035349652,0.073843434,-0.008638617,0.03844248,0.10392215,-0.026827998,0.05726898,0.06689603,-0.023946557,-0.03684575,0.01967045,-0.009489213,-0.08864527,-0.016897535,-0.011941301,0.01734579,0.01833835,0.058117904,-0.060008783,0.027843019,-0.030538741,-0.027000606,0.017917348,0.026071047,-0.029762452,-0.07556881,0.018096589,0.048166864,-0.013335549,-0.024330473,-0.10064954,0.03793181,0.016134873,-0.010157293,0.06285103,0.041882977,0.018893402,-0.018444948,-0.1256804,-0.046522204,0.011903305,0.05251109,-0.062391773,-0.009836213,-0.00983537,0.0038822114,0.078763984,0.05086493,0.052511472,-0.032223918,-0.09708805,0.01886347,-0.064073235,-0.11867015,0.030368451,-0.040565953,0.033798274,0.043835685,0.11401742,-0.06967773 +1.14.13.195,"A flavoprotein (FAD). The enzyme is involved in biosynthesis of N5-hydroxy-L-ornithine, N5-formyl-N5-hydroxy-L-ornithine or N5-acetyl-N5-hydroxy-L-ornithine. These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa). The enzyme is specific for NADPH. cf. EC 1.14.13.196, L-ornithine N5-monooxygenase [NAD(P)H].",384,1.0,-0.10454447,-0.03293692,-0.07687387,-0.030140458,0.12097266,0.06256921,-0.103139855,0.06349737,0.0504761,-0.018556604,-7.998406e-05,0.025993029,-0.058795754,0.037929013,-0.082554035,0.04677621,-0.061690476,-0.03889997,-0.027942142,-0.011409538,0.051940262,0.05855354,0.028432505,-0.033198334,0.049226794,0.009947678,0.03281915,-0.009641231,-0.0077440073,-0.027118294,0.009865626,-0.011417277,-0.021962127,-0.039987613,-0.011257155,0.08357983,-0.023687609,0.013959066,0.023063663,0.017675461,0.019386819,-0.040205773,-0.08559948,-0.015300458,0.05212192,-0.037450112,-0.049284432,0.073980235,0.024580091,0.037758477,-0.059793364,-0.028004399,-0.052586414,0.027923029,0.029403782,-0.021322645,0.009432672,-0.09182437,-0.047533162,-0.0070464322,-0.00289327,-0.08388968,0.030346429,0.009348021,0.030179467,-0.05982659,0.014612087,-0.04764514,0.009693523,-0.03321329,-0.071429506,-0.016210698,-0.021453297,0.0578547,0.007092661,0.04254254,-0.03888849,0.036674798,0.048115406,-0.04169268,0.09590429,-0.0056601507,-0.031317364,0.14503247,0.06795519,-0.03281831,-0.027040526,0.075647675,0.018433021,0.030100958,-0.014679164,-0.014038798,-0.002355644,0.012357383,-0.08647248,0.041483887,0.0063816,-0.037687074,-0.030775309,-0.05140914,-0.03844341,0.024188159,0.036523145,-0.03552403,-0.06396842,-0.024599047,-0.041357666,0.0968102,-0.0022132,-0.038815245,-0.01481228,-0.021658504,0.016990677,-0.060548045,-0.03484197,0.054054137,-0.0046452973,-0.050432608,-0.024689533,-0.035395995,-0.035646897,0.06045924,0.02584623,0.12467072,0.0080194995,0.023900326,-0.15712178,4.7054907e-33,0.12151628,0.023532987,-0.019731998,-0.0010423872,0.029799571,0.041098986,-0.03154592,0.022337776,0.06047893,-0.05477155,0.0028271321,-0.08171002,0.03878938,-0.07283823,0.051487867,-0.009369932,-0.03628906,-0.03340366,-0.013061321,-0.04533882,0.017316772,0.041580096,-0.09530056,0.061437964,0.023828518,0.014721972,-0.047354534,0.005716356,-0.01720983,-0.009510676,0.02203569,-0.11520087,-0.05816885,-0.059311427,0.08245815,0.0041497448,-0.042139523,-0.04874374,-0.044831105,0.055039305,-0.046229098,0.036239427,-0.017869685,-0.015301119,0.057169594,-0.053215217,-0.08673836,0.14872679,0.012454512,0.10335811,0.040558033,-0.043886546,0.11797222,0.013593425,-0.06703989,0.05223304,-0.072058536,-0.0062462073,0.0053772405,0.026508708,0.06370203,0.025750782,-0.011041809,0.051306274,-0.07418028,-0.015162943,-0.02302844,-0.06942502,0.03263426,0.10206146,0.008102225,0.016889017,0.08817004,0.063146956,0.024489645,-0.041301813,-0.07210998,0.009322219,0.032310802,0.02452607,0.021876678,-0.008527241,-0.018987356,-0.05978133,-0.049593747,0.05737069,0.021377666,-0.08910727,-0.00067171373,0.0034971333,0.08856483,-0.0933881,-0.02775319,-0.0069711697,-0.0012137614,-4.8756225e-33,0.06331275,-0.11933055,0.027317474,-0.05342695,-0.016423745,0.07115981,0.028722078,-0.029983481,0.012961033,-0.027847638,0.043582086,0.0061865617,0.022106612,-0.012968706,0.072036356,0.016472645,-0.041801855,0.082038164,0.070312046,0.051121462,0.0063977223,0.061717268,0.031686384,0.068200536,0.063882224,-0.0006135628,-0.023738965,0.05438904,0.0109639745,0.077621855,-0.026212445,0.029909354,-0.07897251,-0.042396314,-0.00614043,0.013166666,-0.043859683,0.015394884,0.039636645,0.024363317,0.015884647,0.024252968,-0.011808443,0.017589923,-0.015692346,0.037672132,-0.07781875,0.016781686,0.06776191,-0.09227863,-0.0012999459,0.037524767,-0.0042305207,0.05226468,0.034359325,0.03711061,0.01471885,0.040095296,0.022111086,0.0023431608,0.0058353054,-0.10176319,0.0034375114,0.024851972,0.033148877,0.113729425,0.0024101492,0.055720612,0.027826482,-0.033883907,-0.003586556,-0.0319979,0.05442709,0.058723394,-0.009779121,-0.03804676,-0.048207443,0.0053772572,-0.016253771,0.008996855,0.013171373,0.009653529,-0.053156376,-0.01236663,-0.073952585,-0.10978982,0.056069907,0.09813263,-0.005095201,0.026272753,-0.015380335,0.03842703,-0.038172886,0.021850819,0.07190678,-4.759303e-08,0.07306952,-0.08331611,0.05939044,-0.022998426,0.05430333,0.007906786,0.0043163984,-0.10365893,0.028981216,-0.010102195,-0.020399896,0.11192526,-0.009554347,0.006823057,0.028811377,-0.022837507,-0.028706854,0.047352355,-0.020937836,-0.03601997,-0.068866566,0.02366968,-0.09831323,0.012745579,0.003532493,-0.031154832,0.0068181194,-0.038492225,0.11519009,-0.07352908,-0.036310457,0.018207874,0.04410194,-0.053484388,-0.11453606,0.06541723,-0.04475595,-0.034180317,-0.029385228,0.051444165,-0.0688941,-0.04283367,-0.011777293,-0.018167237,0.06292462,0.013320746,0.03776155,-0.014863026,-0.069689,-0.019909808,0.013813307,-0.019991057,0.058055423,-0.054227155,-0.11510722,0.03616398,-0.031053824,-0.06856113,0.006344436,-0.07034453,-0.028411318,0.05047017,0.17816983,0.023196716 +1.14.13.196,"A flavoprotein (FAD). The enzyme from the pathogenic fungus Aspergillus fumigatus catalyses a step in the biosynthesis of the siderophores triacetylfusarinine and desferriferricrocin, while the enzyme from the bacterium Kutzneria sp. 744 is involved in the biosynthesis of piperazate, a building block of the kutzneride family of antifungal antibiotics. Activity of the fungal enzyme is higher with NADPH, due to the fact that following the reduction of the flavin, NADP+ (but not NAD+) stabilizes the C4a-hydroperoxyflavin intermediate that oxidizes the substrate [3]. cf. EC 1.14.13.195, L-ornithine N5-monooxygenase (NADPH). ",384,1.0,-0.08030421,0.0014691815,-0.14897744,-0.016718121,0.06740966,0.05613388,-0.13109949,0.06860425,0.06648042,-0.004935179,-0.008004978,0.012793754,-0.06346707,0.102378726,-0.1305326,0.037171923,-0.07195847,0.019323176,-0.057219703,-0.011427354,0.004295553,0.017788066,0.10184209,0.012837002,0.024292955,0.06287787,0.011991376,0.015604297,-0.023660982,-0.10864998,0.012438505,0.061622173,0.0060006236,-0.087070964,-0.03397089,0.077810496,0.0041017174,-0.012168649,0.09055062,0.042526707,-0.024791775,-0.0055963728,-0.053369895,-0.014412338,-0.010124895,-0.0120486375,0.012715644,0.086513266,0.09212673,0.026213929,-0.063442245,0.038726114,0.0054941135,0.050009448,0.027268114,0.0233274,0.015162607,-0.06197854,-0.06590536,-0.02159498,0.015219276,-0.04341268,-3.8298338e-05,0.06666521,-0.09078678,-0.019586263,-0.039824586,-0.05764614,-0.014457093,-0.04897735,-0.0708354,-0.06444611,-0.0134276105,0.036781814,0.020463616,0.11445478,0.029854177,-0.0034614317,-0.012839949,-0.003222999,0.12757072,0.017058844,0.02023354,0.081686996,0.058195166,-0.03129357,-0.01107731,0.0038435834,0.054689053,0.07551163,0.034233376,0.036148928,0.05276063,0.0012460253,-0.07779224,0.044021703,0.057891283,0.039870147,-0.056175448,-0.031846967,-0.009611259,-0.04313963,-0.014401358,-0.015768755,-0.004270364,-0.05353102,0.03473351,0.099129654,0.0291631,-0.025637217,-0.002415933,-0.023516815,0.024522182,-0.062462084,-0.022556266,0.029633002,0.05481616,-0.029583432,-0.067166336,-0.031614624,0.011713844,0.033695627,-0.018321605,-0.0021152447,0.014773315,0.012975589,-0.09835546,4.2273936e-33,0.09721139,0.0325595,-0.036197796,-0.03757607,0.06328473,-0.02804991,-0.012251605,0.042237412,0.010965384,-0.074707076,-0.05481282,-0.010415533,0.0030044818,-0.03526946,0.0019168531,0.02189017,-0.027188119,-0.06998588,-0.0020368786,-0.032253783,0.08894667,-0.029779421,-0.09252721,0.05685799,0.030305227,0.052310582,0.029194422,0.038409624,-0.03134902,-0.03319723,-0.027742118,-0.084843874,-0.06080022,-0.023945173,0.07017975,-0.007324577,-0.0498148,-0.04332742,-0.074763045,0.050935045,-0.11188491,0.01664536,-0.08494796,-0.04903812,0.07399677,-0.0625199,-0.106396854,0.11751037,0.06231277,0.09891521,0.096526474,-0.01786024,0.09753881,0.09828253,-0.034947824,0.069576904,-0.023968607,-0.029931873,-0.0052083004,-0.013058048,-0.012479737,-0.001237503,0.0039821365,0.013918856,-0.0048517874,-0.025049478,-0.041715667,-0.067900605,0.021780252,0.05610058,-0.016740793,0.035756502,0.006750687,0.057568353,0.044869553,-0.015898477,-0.08232485,-0.06189988,0.05065024,0.04270563,0.010088346,-0.0052830838,0.031456262,-0.0020583041,-0.089025,0.026521137,0.021402288,-0.010266083,0.018698042,0.0023616678,0.011282515,-0.085003465,0.005753727,-0.04281996,0.036390528,-4.5818863e-33,0.1255862,-0.06126479,0.0058234045,-0.0030219068,-0.048006915,0.082545795,-0.019260997,-0.023528336,-0.015795503,-0.07692564,0.023331434,-0.0019846107,0.044238653,0.02099176,0.040599104,0.038603317,-0.0044458825,0.08972194,-0.011210128,0.0031508608,0.01452208,0.072855555,-0.0073243924,0.052642282,0.05339592,-0.035930146,0.051311124,0.0143520925,-0.011494883,0.08911937,-0.0020360213,0.02548668,-0.040927418,-0.035557006,0.031201554,0.10166509,-0.048266742,0.018937219,0.00810126,0.032415416,0.026654268,-0.010260239,-0.013623871,0.009728026,0.035262123,0.059149634,-0.10329597,0.0059887553,0.061735567,-0.069991484,-0.010943659,0.06383633,-0.046013054,0.03901501,0.047840893,0.019084413,0.034915492,-0.0040083835,0.05651466,-0.027180301,-0.03699551,-0.07474007,0.009046077,0.007406241,0.033213407,0.03040426,0.00037734723,0.060740013,0.07468099,-0.041493274,0.040607523,-0.004791767,0.07296496,0.08652594,-0.019487226,0.020916427,-0.0066232737,-0.006742005,-0.014974445,0.03131466,0.008580565,-0.016070068,0.026707282,-0.076978795,-0.1051858,-0.08757119,0.057219896,-0.001207782,-0.057721674,0.021169148,0.035493426,0.03824411,-0.038106006,-0.014945991,0.07851891,-4.6237847e-08,0.06282809,0.0030197948,0.019571032,-0.0048236586,0.0064924094,0.026903203,0.01623963,-0.050384376,0.041635945,-0.042585716,0.011764005,0.10304692,0.015823642,0.03784235,0.0610407,0.0032221577,-0.038757116,0.0036892158,-0.026224183,0.003823762,-0.07669128,-0.0058706417,-0.1448328,-0.006321492,0.018999849,-0.038693346,-0.018643714,-0.05777198,0.09073887,-0.004656217,-0.005446068,0.027001463,0.04555681,-0.04716315,-0.07942172,-0.018430203,-0.039977495,-0.045849077,-0.021966524,0.027781505,-0.033214033,-0.09605523,-0.05681827,-0.0007667682,-0.042513855,-0.011340826,0.011678259,0.008036291,-0.065394215,-0.042697955,0.07410012,-0.0050844913,0.02630298,-0.036666267,-0.10991884,0.03315581,0.025924403,-0.0063117463,-0.074275464,-0.111793354,-0.08608705,0.0016272202,0.14088474,-0.015291931 +1.14.13.197,"A heme-thiolate protein (cytochrome P-450). The dehydration of 3alpha-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous [1,2]. The enzyme from fungi also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase [3].",384,1.0,-0.055995096,-0.028013494,-0.017995201,-0.021036811,0.106367454,0.044082753,-0.023719316,0.090302825,0.0148121435,-0.0038335854,0.023282813,-0.08763973,-0.07744923,0.024775056,-0.05334214,0.005123081,-0.072935335,0.0053085634,-0.02547113,-0.019614993,0.021014985,0.036117245,-0.05623326,0.03774075,0.05040614,0.0014042788,0.09915497,0.034944784,-0.072683945,-0.07073812,-0.03613677,-0.016297186,0.012541746,-0.044517994,0.058846835,0.10655671,-0.086640716,-0.07522754,0.05343298,0.008926172,0.06305875,-0.07102723,-0.06548912,-0.006210831,-0.07101947,-0.011037653,-0.027243411,0.057285715,0.037871387,-0.021735927,-0.024777295,-0.021407343,-0.008518587,0.015260978,-0.06929196,-0.024697939,0.014008439,0.026695265,-0.028711345,-0.022942511,-0.013846511,0.04699155,-0.03721187,0.021681165,0.025728548,-0.04384229,0.052558947,-0.053096205,0.024136119,-0.038620416,-0.04261283,-0.06343433,0.028971236,-0.013122835,-0.020357864,0.06020431,-0.034633607,-0.027022608,-0.014663811,-0.027844356,0.04693692,0.012126866,0.0010499493,0.10182272,0.0063975365,-0.085909516,-0.03756623,0.050871138,-0.0031531195,-0.022233613,-0.03456329,0.052664064,-0.054576095,-0.0015524547,-0.11767481,0.089925125,0.06906864,-0.007868755,0.045969073,-0.0041345656,0.024401236,0.09581168,-0.007950964,-0.083188124,-0.0115231825,0.008424376,0.012328936,0.1148153,0.08084723,-0.06221627,0.0029729153,-0.09361753,0.06133315,-0.015226025,0.0018268168,0.07746689,0.013134664,-0.05969612,-0.04602679,-0.072093494,0.021576408,-0.039242525,0.026296828,-0.04295165,-0.07390915,0.040515035,-0.0919438,1.5004325e-33,0.09696952,-0.0013900487,-0.040291842,0.020337962,-0.0055563115,-0.017131455,-0.116170995,0.07567248,-0.025471233,0.002089134,-0.038954422,-0.07497474,0.013635993,-0.049644504,-0.057181448,0.005315816,-0.02396313,-0.005628282,0.025787422,0.07390376,0.004582356,0.020006578,-0.04326193,-0.043734565,0.0575345,0.116735324,-0.003318898,-0.03592797,0.011929505,0.02699732,-0.03172106,-0.08894553,-0.083447084,-0.010361423,0.05169288,-0.04602752,-0.0152102895,0.0011817004,-0.0014266643,0.0067605916,0.0124315545,0.010437069,0.06539652,-0.11287538,0.045565337,0.0074360836,-0.09055813,0.0627522,-0.018666066,0.022797577,0.101219214,-0.0590242,0.12254052,0.018183352,-0.024982834,-0.011006059,-0.0069725965,0.06390943,0.039739277,0.09717069,0.0789222,0.13852209,-0.07080538,0.07058771,-0.010698371,-0.008719675,-0.046977337,-0.045990445,0.0074699153,0.0370792,-0.08142548,0.028557284,0.07620642,-0.0720777,0.0021013662,-0.06248283,-0.022599936,0.013870887,0.018290598,0.053127185,0.052320134,-0.029380824,0.021924112,-0.010137809,-0.057321504,0.04415141,0.048456993,0.008167698,-0.08895565,0.045846604,0.009290293,-0.09913872,0.049828276,0.00053947367,0.04049049,-2.8904692e-33,0.13306789,-0.08762233,0.030240737,-0.09156628,-0.029012728,0.112491824,0.021340204,0.029643442,-0.012939395,-0.0060782013,0.11537894,0.0019182106,-0.03664419,0.01800245,0.04291971,0.008153098,-0.001727322,-0.0018645293,-0.012212929,0.018491544,0.025890183,0.039033543,-0.0004952273,0.032553453,0.115449466,0.0045068655,0.03773742,0.048232954,-0.0015435655,0.07094365,-0.05515965,0.07254656,-0.043975826,-0.049871977,-0.041123886,0.044563357,-0.020411491,-0.032082506,0.030988222,0.046542298,-0.024538288,-0.0020614634,0.034425765,0.053252567,0.0338219,0.10061638,-0.09319148,-0.066953965,0.025266489,0.027844472,0.030745106,-0.013043462,-0.06341352,0.02035217,-0.04686124,0.01718962,0.010516764,0.02573175,-0.027178332,-0.032116577,-0.067149855,-0.031235669,-0.025520362,0.063305825,0.006257125,0.08053212,-0.06301434,0.02994828,0.07645508,-0.035639573,0.0709119,0.012805911,0.013984059,0.09060405,0.021486022,-0.011147844,-0.009040909,-0.021161225,0.044926256,-0.014925897,0.026906233,0.005197684,-0.010598889,-0.07192684,-0.009996666,-0.13484895,-0.042256873,0.08935945,-0.055860233,-0.038973235,0.021093255,-0.0073889177,-0.034665193,0.040653903,0.052338365,-4.168752e-08,0.0063144527,-0.07481036,0.022681763,-0.011816368,0.041121226,0.012676712,0.061414972,0.025203787,0.08685913,-0.02817596,-0.0010445005,0.059909344,-0.01636705,0.036383614,0.011991383,-0.00090814545,-0.023666423,0.0013660459,-0.011151577,-0.0030294536,-0.019084986,-0.02333375,-0.09564013,0.019481953,0.005354642,-0.09573569,-0.0023022732,-0.029806755,0.031492338,-0.010049418,-0.0158501,0.041641362,-0.015459398,-0.01103516,0.013739692,0.01107057,-0.06757413,-0.04779435,-0.049176544,-0.0587347,-0.00032242143,-0.012573329,-0.1266724,-0.048823025,-0.026730066,-0.036381748,0.024967266,0.06779175,0.03731482,-0.016312774,0.02596306,-0.010039727,0.015338946,-0.05876937,-0.07646996,-0.0067552226,0.05893834,-0.054024693,-0.060954683,-0.08257689,0.07247106,0.017818281,0.1561382,-0.031091545 +1.14.13.198,"A heme-thiolate protein (cytochrome P-450). The enzyme from fungi also catalyses the reaction of EC 1.14.13.197, dihydromonacolin L hydroxylase.",384,1.0,-0.05341716,0.03367635,-0.023055028,-0.03623209,0.09093297,0.039740518,-0.032032188,0.07967203,0.0035036195,0.011699665,0.025996152,-0.098979935,-0.079803124,0.024887722,-0.05459759,0.026272766,-0.06262585,-0.0046657487,-0.019808458,-0.048702367,0.011878019,0.052000903,-0.011457255,0.06023145,0.008077781,0.015607532,0.067860976,0.061368022,-0.07342394,-0.069979034,-0.03183345,-0.03549604,0.060253948,-0.027383475,-0.010799251,0.10325378,-0.072605826,-0.08066769,0.048155453,-0.017496264,0.039276894,-0.053301685,-0.05592111,-0.0037064604,-0.077189416,-0.032749984,-0.00030909735,0.050675347,0.055300362,-0.04280912,-0.027099112,-0.013131862,-0.01235049,0.028678821,-0.0095324265,0.006392384,0.010054121,0.0004013781,-0.008490056,-0.03325067,-0.031698193,0.019354627,-0.03217553,0.009239919,-0.0220113,-0.057913486,0.0140987635,-0.043378074,-0.028403955,-0.043052044,-0.05580324,-0.07227847,0.0029693726,0.006746912,-0.017856881,0.081969954,-0.040339194,-0.03508082,0.014711605,-0.011399346,0.03994616,0.0194917,-0.014012369,0.08600791,0.01956111,-0.06724156,-0.0019955016,0.040842187,-0.0014873046,-0.0323872,0.027721591,0.044021532,-0.016558804,0.010456505,-0.09864329,0.085631914,0.05829481,0.047429644,0.047680948,-0.022869878,0.04778911,0.09924731,-0.03205678,-0.106297605,-0.062909104,0.008255605,0.022025956,0.14207101,0.07780489,-0.0717185,0.000750056,-0.098481916,0.045690645,-0.023343842,-0.0010030022,0.057522595,0.022268726,-0.036220253,-0.04267981,-0.04521014,0.015571169,-0.033696767,0.014491121,0.0026471997,-0.06712861,0.027248455,-0.11859669,1.1266224e-33,0.097964905,0.04525175,-0.068544544,0.0022205696,0.008159903,-0.010864979,-0.08737186,0.07827032,-0.03387522,-0.03609311,-0.06308617,-0.037782934,-0.018933952,-0.030227654,-0.042540867,-0.010675853,-0.0235856,0.006660882,0.02518584,0.07205006,-0.007850251,-0.0050399024,-0.06699039,-0.013567276,0.05392257,0.106288575,-0.019246997,-0.01683406,0.021469522,0.014471634,-0.039423242,-0.076741874,-0.07930292,-0.019594088,0.043101564,-0.03551951,0.009338448,0.008342486,-0.021297883,-0.0012679917,-0.021765748,0.009979787,0.043068778,-0.1174401,0.063506834,-0.0015887652,-0.08392417,0.06450192,0.006613531,0.04473954,0.0889765,-0.044318683,0.14171468,0.006142671,-0.028397266,0.0115405265,-0.011748683,0.05508979,0.02318663,0.085656635,0.07810961,0.12411468,-0.047598697,0.080584764,0.0003235933,0.010868331,-0.021303024,-0.022174943,-0.0038582692,0.08366377,-0.084909424,0.023308003,0.06604975,-0.08015681,0.026212858,-0.053183563,-0.04879822,0.021133939,0.0017304382,0.070352904,0.030196872,-0.013173669,0.011892341,-0.031960733,-0.011618412,0.024732394,0.016840138,0.031074407,-0.06504366,0.032742746,0.008024535,-0.10258378,0.021039383,0.01738245,0.0041490463,-2.2535797e-33,0.13902245,-0.10087171,0.04513437,-0.08591822,-0.058761984,0.11323521,0.012922014,-0.015555627,-0.029301684,-0.023486072,0.10601952,-0.048689973,0.00828226,-0.014260626,0.020136163,-0.012795048,-0.038156305,0.03719219,-0.02097197,0.027373306,-0.002898996,0.026917843,-0.0025270793,0.028100256,0.091914825,0.0049802004,0.03823969,0.04763924,0.03948123,0.025537139,-0.061346248,0.03464848,-0.034308907,-0.05288387,-0.049319785,0.06708299,0.0010902949,-0.027690005,0.0290722,0.029294813,0.0047164625,0.0207276,0.03855531,0.06686374,0.016674481,0.10075157,-0.08703972,-0.013509444,-0.0037843522,-0.014253761,0.034923673,0.027516227,-0.03465932,-0.005594519,-0.040437266,0.012361085,-0.000714185,0.026975865,-0.005870954,-0.03724802,-0.07111272,-0.04778433,-0.009079553,0.08274606,0.0070495615,0.093641184,-0.09470485,0.029627493,0.057382677,5.443227e-05,0.095999606,0.0056333872,0.02898934,0.08177488,0.029467171,0.020152252,0.009663595,-0.010400953,0.042128604,0.039240047,0.042020656,0.0056073065,-0.0016365682,-0.08435598,-0.0137725845,-0.10580056,-0.01792073,0.09140411,-0.090288766,-0.014884245,0.014655123,0.02028197,-0.019289916,0.03847435,0.057424985,-3.204829e-08,0.0064361165,-0.07248334,0.034954727,-0.06953317,0.040037856,0.018573707,0.07281157,0.012113811,0.06722926,-0.031441797,0.0025036505,0.057818152,-0.011761147,0.035053063,0.034719832,-0.010347454,-0.0042524547,0.006739297,0.0075821267,0.026050182,-0.011859381,-0.022936178,-0.08231447,0.052387297,0.0239263,-0.10682469,-0.013853144,-0.019090932,0.012108278,0.0010856377,-0.021689672,0.02540201,-0.041234158,-0.018230034,0.036368478,0.0129417265,-0.08453243,-0.08423545,-0.039503787,-0.04903199,0.013551458,-0.046436656,-0.105966635,-0.054724526,-0.011148963,-0.021668356,0.028074943,0.06776997,0.009971836,-0.02142097,0.04502702,-0.017310366,0.030378064,-0.112416424,-0.10416627,-0.011369348,0.1011089,-0.0616831,-0.05743811,-0.0830593,0.06497784,0.0031638858,0.1971778,-0.03018289 +1.14.13.199,Isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.,384,1.0,-0.0063548586,-0.09132315,-0.008088085,-0.033967633,-0.020277763,-0.065279305,0.035439882,0.087510064,-0.011200097,0.06627135,0.0796249,-0.05221888,-0.046788696,0.00020382229,-0.06615173,0.07104137,-0.10909999,-0.023000792,0.02730371,0.013790351,0.11129719,0.024734508,-0.027033707,-0.022488222,0.012413961,0.031746168,0.08570504,-0.015470359,-0.024921274,-0.07361389,-0.0813452,0.028309384,-0.048672326,-0.030387053,0.093909904,0.023233833,-0.0339671,-0.0034705442,0.012478525,0.0038415624,0.035615478,-0.049968228,-0.023331542,-0.03482859,0.025736725,0.017509472,-0.042425927,0.061919797,0.0005134114,-0.012489079,-0.09208611,-0.06764973,0.0010760574,0.0020021333,0.020928325,-0.008324146,-0.054047674,0.04762985,-0.002491512,0.10068495,0.074149825,0.00021381366,0.0063981684,-0.036524277,0.0460762,-0.02881762,0.043331705,-0.08585725,0.0483407,-0.07757071,-0.030016994,-0.057767354,0.017334018,0.018172512,-0.036731236,0.025053373,0.006456692,-0.0821299,0.07793828,-0.053347994,0.07926992,0.07259538,0.064904556,0.040737223,0.02888617,0.025372105,0.008874195,0.026815679,-0.0105037335,0.018787928,-0.010979535,0.009718477,-0.115840144,-0.06392185,-0.054930937,0.0053310054,0.0586979,0.04480603,-0.0052211597,0.027476856,0.042955488,-0.015082001,0.071796596,-0.047430687,-0.08877261,0.05733912,0.054613113,-0.042949785,0.036228534,0.008923315,-0.0038622152,0.10635217,-0.044129394,-0.03866849,-0.031577628,0.0051786313,0.0072129285,-0.0988797,0.04293926,-0.016994322,0.014370294,-0.013274621,0.079951175,0.052185036,-0.014269682,0.058063075,-0.026263086,2.7497302e-33,0.04572952,0.097824074,-0.0093718385,-0.03963119,0.015084187,-0.02834332,-0.041571535,0.015290411,-0.13010003,-0.091276675,-0.05587914,-0.058953464,0.031915,0.036000043,-0.033974472,0.026964294,0.0049448167,0.030869335,0.05560439,-0.040194217,0.003610996,0.08175165,-0.098152295,-0.016075037,-0.030738117,0.002636979,-0.052232273,0.00044641114,0.05481265,0.009535957,0.0650727,0.009150166,0.0016155838,-0.025492785,0.027586278,0.013694965,0.022246797,-0.018145064,-0.072376795,0.055131286,0.0038927852,0.044992875,0.057396896,-0.06281362,0.047265187,0.0069312355,-0.013935664,0.066678494,-0.006193364,-0.024179308,0.02375896,-0.0022422096,-0.010530746,-0.090585954,-0.0471078,0.059050944,-0.025254242,-0.094667755,0.043456264,0.11380322,0.03241761,0.07147274,-0.02607412,-0.004069727,-0.015884558,-0.060225513,-0.074762195,-0.031192094,-0.07654925,0.0072740926,-0.061993346,-0.063084796,0.04366226,-0.023606924,0.0040971166,-0.027156474,0.0032165304,0.05000568,-0.014965929,-0.07874134,0.044981502,-0.029264646,0.09856658,-0.04193188,-0.028846337,0.081776045,-0.009605177,-0.0019539932,-0.0829456,0.043185282,0.07772796,-0.06579121,-0.13203283,-0.028687244,-0.008199425,-5.1255572e-33,0.044888582,-0.0625111,0.03243729,-0.09902334,-0.00931748,0.10058846,0.044570852,0.063871235,0.05988754,-0.023289952,0.08811713,-0.055708677,0.030783286,-0.07649176,-0.016815947,-0.00715132,-0.05241801,0.065485194,0.038545273,0.07057801,-0.0072977818,0.085672475,-0.005566021,-0.0023877718,-0.010286981,0.02532184,0.0123929,0.027228855,-0.002532703,0.037286054,0.0073644994,-0.01289735,-0.08704112,-0.078818984,0.039003003,0.03343848,-0.13060085,-0.03249217,-0.03503211,0.028366901,-0.056612022,-0.0013126634,0.037713192,0.056106877,0.06620603,0.0059765386,-0.0755539,-0.018312484,-0.048031498,-0.002735902,0.03155478,0.01719374,-0.01973475,0.01847018,-0.07833812,0.060611136,-0.011266103,0.07574108,-0.040022552,0.044374336,-0.03823717,-0.066262804,-0.004282649,-0.051280208,0.12744871,0.038055185,-0.07681066,0.042847484,0.046196774,-0.013341764,0.06966771,0.023425343,-0.09206561,-0.003369541,-0.021972904,0.005192359,-0.08953424,-0.019358924,-0.029255413,0.03613618,0.046431303,0.01534643,0.062070694,0.063867204,-0.05462043,-0.043321434,0.056351062,0.07725293,-0.016574811,-0.017107313,-0.028807655,-0.01012561,-0.16957633,-0.012079012,0.026140781,-3.408784e-08,0.0037337793,-0.019441258,-0.007218266,-0.031092744,-0.053210814,-0.08257831,0.036281247,0.04699158,0.026264478,0.008033773,-0.07814268,0.085446656,-0.029271012,0.051812787,0.041976586,-0.0018577809,-0.006543894,0.072068796,-0.03146366,-0.009804053,-0.058817152,-0.04316369,-0.010140826,-0.010976031,-0.049674854,-0.004190562,0.064111106,0.045512408,-0.04417138,0.04315456,0.04864791,0.011201408,0.0013422819,-0.019671476,-0.02191769,-5.0400067e-06,-0.06759728,-0.0018292512,-0.058305796,-0.010167249,0.027518863,-0.07313862,-0.003377497,0.054740593,0.022790605,-0.0020201048,0.030689366,-0.021096265,0.098751985,0.0007074422,-0.009030137,-0.029119464,-0.040413328,-0.060159076,-0.08741751,-0.059329674,0.04544094,0.008812778,-0.0067606657,-0.081930965,0.04825669,0.041835416,0.17513359,0.015501052 +1.14.13.200,"Isolated from the bacterium Streptomyces glaucescens. The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis. The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide. Water opens the epoxide giving two hydroxy groups. The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group.",384,1.0,-0.068004854,0.004677551,-0.14046782,-0.012884718,0.03723399,0.0076612653,-0.06723311,0.06050743,0.047897737,-0.046149977,0.035711817,-0.008596007,0.08921425,-0.0035901417,-0.06498218,0.0011277697,-0.05426053,-0.02024784,0.028628385,-0.06777888,0.098490514,0.059138767,0.014810529,-0.032789648,0.06699538,0.020854628,0.025209054,0.047700185,-0.040125623,-0.10548855,0.086982585,-0.020116653,0.03304258,-0.06954746,0.05840079,0.110029645,-0.06231433,-0.015145876,0.12392813,0.030987022,-0.053925797,-0.0031359086,-0.031881105,0.03389901,-0.049400236,0.020460699,0.0077142245,0.06414279,-0.012399507,-0.0242886,-0.013513761,-0.058467425,-0.06312838,0.04032942,0.06777645,0.0030332324,-0.0070288302,-0.035681773,0.014600609,-0.021739027,0.10585307,-0.01673593,0.01708506,0.032511853,-0.11002607,-0.025565742,0.028382061,-0.08896112,0.06161871,-0.08575205,-0.042373892,0.022605695,0.035262052,0.023188982,-0.013583074,-0.01970723,-0.010371276,-0.03205747,-0.052579764,0.034804102,0.029750083,-0.04145278,-0.0044277892,0.102634415,0.04650551,-0.046225443,0.028790051,0.0028780375,0.030641243,0.061307043,0.041386493,0.023900354,-0.016417632,-0.042378224,-0.027972624,-0.030485025,-0.0063126725,0.0014076114,0.010921869,-0.003752073,-0.07639777,-0.02921195,0.016288277,-0.024986718,-0.008034435,0.01797114,0.02523844,0.06830171,0.039521426,-0.06620152,0.0032103565,-0.014716409,-0.0003774808,-0.028229898,-0.018680284,0.06569403,0.14399783,-0.07386784,-0.045346085,-0.010240527,0.021786584,0.03499513,0.049184494,0.0026542088,-0.03536392,0.10373761,-0.06502096,3.8534942e-33,0.0043289014,0.038286954,-0.05396672,-0.02922544,0.04993644,0.041618984,-0.08621729,-0.019511482,-0.01989316,-0.05448096,-0.0706122,-0.03749432,0.016482346,0.03585064,-0.016301187,0.0071458984,0.007357031,0.03977804,0.031758886,0.0042667584,0.013666389,0.017980402,-0.0754864,0.043783687,0.0026285697,0.06651593,-0.0016574052,-0.0042229183,0.14389141,-0.016124396,0.038805816,-0.041134745,-0.05971408,0.0049765543,0.104879215,0.012484658,-0.08096826,0.00947403,0.06343601,0.011054405,-0.0065132705,0.045365114,0.028785046,-0.068458885,0.09046121,-0.05349244,-0.06930755,0.06656203,0.104737535,0.02140101,0.047157872,-0.014522397,0.09456926,-0.031495698,-0.08759929,0.032899726,-0.003660358,0.06339392,0.05950429,0.030413494,0.0075254943,0.066854864,-0.007016505,-0.0071576815,0.05763988,0.03556774,-0.06249204,-0.04052766,-0.03690271,-0.001487213,-0.05915096,0.019515926,0.05386099,-0.012428726,-0.0020194503,0.01502114,-0.0535605,-0.041901402,0.04147181,-0.009699084,-0.019775778,0.011244151,0.0064635114,-0.07473062,-0.045595516,0.062457714,-0.03538049,-0.05200819,0.039890382,0.09551962,-0.028329464,-0.072897345,-0.13081904,-0.03421893,0.044032257,-4.8120775e-33,0.095167145,-0.034202166,0.08990151,-0.06313765,-0.012409116,0.115688056,-0.036773726,0.002504862,0.0220055,0.035805635,0.0805917,0.0067757973,-0.043311305,-0.06905094,0.011731979,-0.05821488,0.027536845,0.12721951,-0.025794964,0.043140758,0.024935082,0.081494674,-0.010731707,-0.018600103,0.036214203,0.024207726,-0.02711049,0.0482852,0.03698459,0.041241508,-0.02920137,-0.042575855,-0.032067224,-0.03039148,-0.03595213,0.08869902,-0.13958149,-0.0119086,0.082122535,-0.004044723,0.037551567,-0.03424319,0.007995574,0.051794734,0.049770508,0.061891895,-0.049819667,0.024971768,-0.01411856,-0.033327043,-0.0009536302,0.042752635,-0.047349274,-0.00884503,0.010924222,-0.023656247,0.036915638,0.013342518,-0.040101677,-0.06622738,3.4046105e-05,-0.04387574,-0.014373962,0.022821572,0.015442561,0.05965453,-0.026187683,0.08002453,0.054086834,-0.034592584,0.005159673,-0.0068827355,-0.014417808,-0.014281195,0.06719827,-0.0060163653,-0.13212565,-0.064167954,-0.06252512,0.008394967,0.031366706,0.008884749,0.047289263,-0.059880197,0.0024172193,-0.093004964,0.0049041123,0.020685222,0.022927733,0.027189177,-0.004539999,0.037132084,-0.04914403,0.0060771084,0.083177514,-4.1003787e-08,0.033556063,0.008549657,0.121405505,-0.026130984,-0.009850138,-0.051630676,0.015845224,-0.013373207,0.027984835,-0.019441362,-0.043536697,0.038429163,-0.016574685,-0.04345892,0.0012863604,0.034826063,-0.08231219,-0.04186656,0.010418716,-0.020752648,-0.0796123,-0.04017894,-0.025127871,0.07001729,0.0069592837,-0.053532273,-0.01666034,-0.06038316,0.013090925,-0.023387078,0.06951357,0.021039126,-0.0683166,-0.021105096,-0.099089466,-0.02002717,-0.08016326,0.023557896,-0.006860942,0.003285809,-0.009717341,-0.03343879,-0.09809104,0.0322983,-0.086500995,0.036632095,-0.02094494,-0.03342594,-0.09163186,0.003966253,0.065508895,-0.0013688984,-0.006705764,0.0032255962,-0.13334882,0.00070619007,-0.005792418,-0.054234,-0.06719824,-0.07106501,-0.0635783,-0.013254998,0.17518893,-0.015950268 +1.14.19.9,"A flavin-dependent halogenase. The enzyme from the bacterium Lechevalieria aerocolonigenes catalyses the initial step in the biosynthesis of rebeccamycin [2]. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. Also acts on bromide ion. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.59, tryptophan 6-halogenase.",384,1.0,-0.06409644,0.0081485985,-0.15263765,-0.028326644,0.09481302,0.069120735,-0.076250106,0.06250304,0.076456666,-0.000742836,-0.0071596946,-0.11210874,0.03733079,0.052439995,-0.100877695,0.04256925,-0.043702014,0.015633542,-0.0011207269,0.0047938065,0.006483257,0.021887451,0.0019979088,0.04410505,0.027789844,0.023552286,0.05136412,0.006086307,-0.078849025,-0.059593417,0.048788305,-0.010009166,0.075105354,-0.034840677,0.07568318,0.090469204,0.03515049,-0.04321255,0.13611239,0.02037476,-0.06974678,-0.0069296155,0.013726278,0.0020401732,-0.013885651,0.0017521961,0.04171881,0.06779187,0.018569348,0.016268505,-0.044960868,-0.040153224,-0.047484905,-0.014801983,0.08580739,0.013000579,-0.106433965,-0.04353384,0.04017614,-0.016586978,0.019439165,-0.009984749,0.0051049185,0.027358579,-0.042406823,-0.102082185,-0.023380565,-0.07438681,0.06623918,-0.05071444,-0.052751858,-0.049927276,-0.0077906395,0.02001043,0.0075815264,0.02332756,0.004567763,-0.061111584,-0.0123167755,-0.041031238,0.02184527,-0.025407411,0.07035599,0.121292315,0.037659578,-0.013408107,0.027754597,-0.003617366,0.024218446,0.05890914,0.025993025,0.014372171,0.031551603,-0.06832852,-0.055394676,0.0034309006,0.003110195,0.009029409,0.0097222105,0.0077675306,-0.020646652,-0.0086507145,0.011743112,-0.03917021,-0.030144757,-0.035740573,0.03976248,0.111019254,0.03228976,-0.06868541,0.03504278,-0.022242337,-0.010108429,-0.043300737,-0.031089786,0.13754739,0.0748156,-0.16146235,-0.15914293,0.012911855,0.01636962,-0.010509986,0.008211356,0.039007064,-0.03205478,0.035958383,-0.10638243,3.386449e-33,0.07535154,0.026457231,-0.014478652,-0.0005746145,-0.046316847,-0.04099038,-0.059959035,-0.04162836,0.011404579,-0.07909254,-0.05399356,-0.019468676,0.0049279095,-0.04783746,0.026347054,-0.010460337,-0.06447897,-0.025027486,0.009789443,0.038493413,0.002169498,0.012855271,-0.0006165172,0.007373458,0.07979865,0.047567893,0.010764308,-0.024531737,0.10267475,0.018481914,0.013896235,-0.024213452,-0.043479335,0.01641086,0.022086006,0.043704696,-0.0725327,-0.022668878,-0.03917809,0.079765536,-0.0411444,0.06756578,-0.025237588,-0.030804534,0.057712708,-0.08582826,-0.02827195,0.106902786,0.09867936,0.0645582,0.018340096,0.004474887,0.09224975,-0.0024169667,-0.061134793,0.057931066,-0.005901931,-0.00881238,0.04547848,0.01896719,0.024202637,0.013986807,-0.03408201,0.009920069,0.10463273,-0.010247177,-0.011635511,-0.045660112,0.014299044,0.0593044,-0.025390742,-0.031168506,0.11091965,0.026878303,0.032827724,-0.009233902,-0.022129636,-0.018574802,0.009820918,0.0077994945,0.12146481,0.014647185,0.06237714,-0.0694315,-0.060198057,-0.0032732682,-0.023445144,-0.07553948,-0.06792601,0.03156788,0.032443725,-0.09351287,0.00053891656,-0.034583475,-0.021000328,-3.6440178e-33,0.07924216,-0.0944443,-0.02077526,-0.015531879,0.002058348,0.13198254,-0.033833556,-0.08079916,-0.039472736,-0.0016063801,0.06587945,-0.043405086,0.017596489,-0.024026494,0.08261847,-0.012013491,-0.009305117,0.07084624,-0.02314976,0.016773785,0.042016033,0.04557276,-0.0023961586,-0.0028123492,0.030112125,0.06681677,-0.0105675245,0.017575989,0.07202952,0.05598513,-0.096141726,0.0154267885,-0.03559715,-0.045187168,0.01499237,0.03963748,-0.07069709,0.05540216,0.012922692,-0.0043806303,-0.00884005,-0.029861972,0.02930952,0.012294101,0.028432712,0.059768014,-0.048860114,0.023752306,0.047754817,-0.07755702,-0.02728731,-0.009178118,-0.09442583,-0.00035365715,0.035500824,0.028566385,0.07504887,0.03237885,0.032171417,-0.060316823,-0.08863176,-0.03611496,0.027157469,-0.0011717225,-0.0028576117,0.07080919,-0.041889805,0.041158427,0.021273253,0.00031183046,0.035799906,-0.02425499,0.107274085,0.014486892,-0.004506279,-0.0075063813,-0.040282954,-0.050864995,-0.01756551,0.04777626,-0.0027528086,0.039612588,0.053432874,-0.011354327,0.005205725,-0.10387804,0.03692265,-0.006163745,-0.033566583,0.016901053,0.028307928,0.01056183,0.021856053,-0.015298285,0.051175244,-4.3462816e-08,0.038158525,-0.055994075,0.07316482,-0.020092268,0.0017173385,0.059332553,-0.014221055,-0.027040761,0.03584471,-0.060223166,0.004202846,0.06748209,0.08893457,-0.051204264,0.01891252,-0.0030242016,-0.043513425,-0.011986507,-0.043579645,-0.012858307,-0.13126299,-0.010715034,-0.04148251,-0.0076098843,-0.0022341774,-0.007256296,-0.035890833,0.013677059,0.014415498,-0.022591064,0.007722435,0.069636166,-0.041934453,-0.07194782,-0.13548358,-0.03053473,-0.018773027,0.00387921,-0.056370795,0.0045634913,0.038184512,-0.011284664,-0.13358152,0.050353184,0.035718054,0.028888075,0.026408521,-0.019928027,-0.08768266,-0.023663651,0.041811164,-0.0073874383,-0.013095672,-0.021190599,-0.09221518,0.04192488,0.026449943,-0.11169078,-0.017777836,-0.07547465,-0.02984613,0.0161587,0.14466242,0.021032274 +1.14.99.49,A heme-thiolate protein (P-450) enzyme involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.,384,1.0,-0.05551668,0.022412421,-0.17502552,0.043693587,-0.0052597905,0.09910364,-0.025172943,0.108678386,0.04214792,-0.076908775,-0.07144542,-0.03414269,-0.02603177,0.068065114,-0.106849395,-0.05972232,-0.05486352,0.039229933,0.07849228,-0.1305322,-0.00086982554,0.108161286,0.074772865,-0.002482345,0.02119327,0.0060340385,0.03836726,0.05432724,-0.051466335,0.013394692,-0.014772062,-0.059871074,0.008804553,-0.014388706,0.060022164,0.09394101,-0.024231443,-0.06762838,0.084252246,-0.018396266,0.048620075,-0.027393905,-0.08218183,0.07358879,-0.02856978,0.010393925,0.013245195,0.072377585,0.016735416,-0.028727012,-0.017806144,-0.06943352,-0.056395244,0.06396886,0.015263677,0.011263951,0.042037595,0.009328212,0.06496253,-0.05392121,0.08492063,0.011562891,-0.030207679,-0.05687978,-0.054325428,-0.04006896,0.05779944,-0.031359285,-0.008525356,0.02185872,-0.04974095,0.0074745542,-0.022516228,0.05166626,-0.07405528,0.07789034,-0.00070813973,-0.050098125,-0.088792376,0.03516956,0.09628406,0.013282909,0.03580893,0.08062654,-0.014633237,-0.0045938636,-0.014217096,0.075084634,0.0016588508,0.0038035808,0.014213741,0.029147068,-0.02819404,-0.03635647,-0.095158204,-0.026980545,-0.033299483,0.02284088,0.046851505,-0.05716122,0.01062262,-0.008713163,0.025358915,-0.025008203,-0.0025278965,0.031013642,0.01698897,0.09184785,0.05154619,-0.06835825,-0.04570727,0.006064071,0.04169381,-0.069355056,-0.00780685,0.08699345,-0.007212433,0.028789647,-0.049127664,0.062282003,-0.02176063,0.046312653,0.0041305996,0.02952816,-0.028655397,-0.02294693,-0.12836841,1.1750672e-33,0.04812198,0.077826634,0.050989825,0.007213452,0.039877612,0.008602245,-0.09209003,0.0066808225,0.012071132,0.015473734,-0.028796086,-0.13430643,0.027407078,-0.03053532,0.015199317,-0.022291115,-0.042442862,0.00092415843,0.019420395,-0.0006698606,-0.034886844,0.034694526,-0.015458261,-0.01056719,0.022850703,0.06304818,0.009175804,0.05780532,0.06565461,-0.0359443,-0.03803229,-0.042644545,-0.05555078,-0.049736377,0.10434147,-0.06796984,-0.017018951,-0.010146551,0.040784605,0.015964104,-0.0150985,-0.017498644,-0.015773557,-0.022399738,0.041654035,-0.06785093,-0.0778548,0.079154745,0.020703433,0.06281775,0.04163881,-0.08046971,0.07088415,0.038382605,-0.09157489,0.008711945,0.0019403241,0.079798914,0.044484153,0.034563676,0.10900765,-0.01631954,-0.019777613,0.010974116,0.02256839,0.060573902,-0.047395296,0.011805705,0.0018809956,0.088251,-0.043669865,0.030845122,0.01707215,-0.013675689,0.03271306,-0.023902893,-0.09978172,0.022149025,0.060184505,-0.02280078,-0.040758617,-0.018894669,-0.07452023,-0.04923326,-0.042296536,0.057403322,0.0064315577,0.011664258,0.0051467596,0.050136093,0.028252702,-0.13020422,-0.02739799,0.019819703,-0.0026494416,-1.4511661e-33,0.10764403,-0.05164132,-0.0025058386,-0.032346684,-0.049881987,0.042573597,-0.034217663,-0.06827913,-0.11973615,-0.03937303,0.117712416,0.012746065,-0.03366188,0.009266367,-0.02119954,-0.026869202,-0.01888434,0.0010233909,0.001988101,0.022066908,-0.018676132,-0.022607807,-0.038161267,0.02899222,0.016590929,0.010126545,-0.015722342,0.05720618,0.04212203,0.06786639,0.017552987,-0.031449072,-0.080544226,-0.08222549,-0.043275833,0.04754061,0.030321278,0.027211709,0.08826422,-0.011881178,0.0069174822,0.02986953,-0.005014957,0.084695935,0.044577777,0.12956728,0.008417944,-0.06342663,-0.02323806,-0.014973056,0.013904359,0.046119016,-0.03814399,-0.019570252,-0.057109002,-0.004736788,-0.0029865352,0.015075053,0.04980488,-0.046969708,0.018026663,-0.029862534,0.049211066,0.045989845,0.07076376,0.051335633,-0.008889873,0.075477,0.15709917,-0.046073616,-0.009712118,-0.017513638,0.030048436,0.08269323,-0.05530494,-0.010045845,0.0406253,-0.023411416,0.07457313,-0.0038080027,-0.013814602,-0.033944704,-0.049565148,-0.093174286,-0.00808667,-0.026165009,0.01968822,0.07796656,0.0043259547,0.026544608,-0.020290917,0.015579674,-0.010886801,0.03482545,0.009275129,-2.6825585e-08,0.030599788,-0.0950931,0.020982668,-0.038651865,0.05643277,-0.03024745,0.018729907,-0.0328066,0.02540521,0.0073272455,-0.03602977,-0.039902903,-0.0321089,0.0180181,-0.05302743,0.0057224547,-0.051029764,0.0136967115,0.04854078,0.016412538,-0.08343802,0.038007792,-0.090005025,0.054511946,0.07600555,-0.09137892,-0.005445915,0.043173507,0.051157426,0.023725491,0.050093975,0.028664256,-0.025435673,-0.038616125,0.0150364535,0.025226323,-0.11168053,-0.016603686,-0.0011967638,-0.07481264,0.049660634,0.021414194,-0.05787342,-0.011541565,-0.044440784,0.023801835,0.03069829,-0.0069892853,-0.06492,-0.018880151,0.06833895,0.00094707066,-0.005984087,0.0077532856,-0.112949334,0.025619784,0.045265827,-0.04013707,-0.061558265,-0.041391727,-0.06267788,-0.046142936,0.13840716,-0.055821437 +2.4.1.329,"The enzyme, isolated from the thermophilic bacterium Thermoanaerobacterium thermosaccharolyticum, catalyses the reversible phosphorolysis of sucrose 6F-phosphate. It also acts on sucrose with lower activity.",384,1.0,-0.08594938,-0.028026005,-0.110596605,0.05094253,0.02899414,0.05180764,-0.042644594,-0.028053299,0.018153816,0.09844915,-0.014392665,0.010967523,-0.07259932,0.029392002,-0.05244209,-0.006220923,-0.08450216,0.0094413245,0.020814834,-0.008844749,0.13589153,0.04955283,-0.051224813,0.004954107,0.10475527,0.00564157,0.04353457,-0.011766615,-0.032476086,0.021965744,-0.04924702,-0.05771398,0.053086992,-0.02276993,0.06845272,0.13477446,-0.033329938,-0.02455168,0.0396367,-0.00013537526,-0.00815935,-0.028236207,-0.0052276994,-0.039180987,-0.07495714,0.009198213,-0.031627122,0.014288673,0.05168676,-0.042575385,-0.02730415,-0.038694564,-0.09133062,0.008574084,-0.0069633503,0.008696714,-0.04256666,-0.0137124965,-0.008793839,-0.0021902253,0.0022067628,0.0031589519,0.0085541075,0.096596844,0.05786932,-0.06695955,0.039634362,-0.0146651575,-0.03722149,-0.002418843,-0.06646132,-0.045846455,0.04508127,0.0051036924,0.037438355,-0.008993678,-0.035023555,-0.031114152,0.018801298,0.0065965466,0.074679464,-0.08385513,-0.012750373,0.09942855,-0.0144006405,0.007622048,0.052142423,0.0055086752,0.116788805,0.011619909,-0.023748461,-0.009629127,0.03060094,-0.11354131,-0.06363021,-0.0017911438,-0.0641194,0.029194348,0.08229769,-0.04255133,-0.0015679896,0.03649352,0.03446257,-0.09981925,0.0088514015,0.07116472,-0.061753742,0.061616603,0.047951363,0.036147524,-0.031481657,0.072312236,0.03866771,0.00020477525,0.0126863895,0.040887643,0.028395046,-0.09537222,-0.09760029,0.0059530633,-0.020312712,-0.045795366,0.05650399,0.08989291,-0.08788708,0.087183185,-0.091811836,4.3098982e-33,0.039678488,0.027243668,0.07292798,-0.08767488,0.02564439,-0.020176632,-0.041447908,-0.013395248,-0.116340086,0.017629571,0.021779727,-0.009723559,0.07135152,-0.01725372,0.012696876,-0.017233692,0.025744418,0.048759498,0.039665803,-0.0045263707,0.002199877,0.059497714,0.014378992,0.0004322612,-0.0010543538,0.065511584,-0.033346422,0.008027594,0.0039351187,-0.0042094216,0.06620175,-0.064015284,-0.106640026,-0.014438496,0.06837357,-0.07010724,-0.09907862,-0.04173386,-0.0026935728,-0.007452248,0.013463108,0.030420648,0.024490487,0.020314503,0.016701313,-0.01990385,-0.03591235,0.10654644,0.04538533,0.079541005,-0.031440437,-0.033799183,0.056701276,-0.01894113,-0.05525353,0.019606093,0.018140042,-0.0051935352,0.01689102,0.024469968,-0.024560405,0.04914844,-0.07600326,0.018317359,-0.016112728,-0.04785017,-0.03740303,-0.06464717,-0.016740754,0.07832669,-0.11681943,0.0011032182,-0.01313282,0.0037747303,0.03364217,-0.015205935,-0.004290248,-0.04442251,-0.06399926,-0.005201865,0.0021122906,-0.042425238,0.031110413,-0.04824198,-0.060084652,-0.009014417,-0.0388241,-0.07190801,-0.047201235,0.054486167,0.016179746,-0.12517373,-0.06501251,0.07158794,-0.019666174,-5.6459508e-33,0.12182343,-0.09398911,0.032517254,-0.06654844,-0.039263334,0.025355352,0.07179873,-0.015175343,-0.033134602,-0.025189906,0.046544075,0.0136653595,0.09624189,-0.047450468,0.058716875,0.04677928,0.09064424,0.05796266,0.0445164,0.007137451,-0.014319203,0.12686272,0.019672012,-0.02305803,0.016982496,0.0074207494,0.015364553,0.07418738,0.023377879,0.0058140387,0.005308166,-0.023839165,0.003576552,-0.08736802,-0.11999023,-0.020258643,-0.05076797,-0.027723836,0.09318876,0.008344671,0.03972337,0.04419958,0.014509901,0.014396827,0.004998297,0.030518921,-0.06798529,0.058405392,-0.027807092,-0.00088529027,0.018231478,-0.021094559,-0.011274648,0.031312604,0.020648189,0.021052223,-0.027794816,0.0028782878,-0.053071596,-0.03723177,0.033178944,-0.061393067,0.0699424,0.03708271,0.031157237,0.10639051,-0.004132993,0.00765579,-0.011855099,-0.03372733,0.0028767209,0.010511773,-0.025896776,-0.018972306,0.0288648,-0.015316282,-0.09913776,-0.012637365,0.006547716,0.013388311,-0.023220086,0.048235394,-0.005503282,-0.05867995,0.036419395,-0.11114106,0.050215773,0.041523676,-0.009119738,0.029353471,-0.05639222,-0.047814343,0.008085254,0.03854506,0.07831709,-3.2596763e-08,0.011400349,-0.050981406,0.08853335,-0.078627765,0.0288329,-0.0062465407,0.017132081,-0.018743481,0.026295051,-0.023440829,-0.00034365468,0.033852093,0.056070447,-0.0029033136,0.04365816,-0.010938486,-0.065048836,0.010972591,-0.051427197,-0.033731688,-0.021333298,-0.06681624,-0.10127815,0.08194567,0.040605586,0.022873608,0.027688712,-0.042927805,-0.06260071,0.00018248484,-0.06613414,0.018815842,-0.033196364,-0.020548405,-0.06995403,0.065119185,-0.022487108,-0.046907693,-0.05339378,0.045990635,0.060828462,0.02064627,-0.043828614,0.07865701,-0.07441394,0.047587868,0.011571291,0.018371021,-0.03382358,0.024691204,0.057122752,-0.03253158,-0.11038028,-0.040332377,-0.08427373,-0.053146012,0.035320666,-0.06518006,-0.051583663,0.03023531,0.069145285,0.014398459,0.20899652,-0.035572253 +2.4.1.330,"The enzyme, characterized from the plant Gardenia jasminoides, adds a glucose to several crocetin glycosyl esters, but not to crocetin (cf. EC 2.4.1.271, crocetin glucosyltransferase). ",384,1.0,-0.07394173,-0.0132995825,-0.15264376,0.007823741,-0.020233158,0.02452233,-0.021691257,0.01786741,0.00436208,-0.02228498,0.061689343,-0.05534288,-0.072350726,-0.020831289,-0.07876813,0.0046046977,0.006317,0.033477526,-0.026031287,-0.035916734,0.07471024,-0.0002469905,0.049636666,0.06690863,0.09047933,-0.05108495,0.006527636,-0.0003585038,-0.041885983,-0.031468373,-0.084925026,0.0038546026,0.058253508,-0.002552391,0.07499737,0.093068324,-0.0013185627,-0.077838,0.0669671,-0.04361256,0.03397139,0.0013407056,0.01880156,-0.037378844,-0.020646838,-0.08238176,-0.019910209,0.0248369,0.047272988,0.012786141,-0.044740964,-0.06911059,-0.09634322,0.011752712,0.020122679,0.041966293,-0.078413844,0.01453907,0.010648348,0.024399634,-0.054991078,0.03444811,-0.016923254,0.05376372,-0.05302979,-0.10295429,-0.044491697,-0.02644386,0.0012783429,0.012490011,-0.007042682,-0.05763074,-0.00292709,-0.06121641,-0.018581009,0.029682763,-0.060474284,0.0403208,-0.027248014,-0.011892072,0.020609973,-0.02862353,0.093716234,0.03722269,-0.009864966,-0.0016935172,0.048742965,0.01816437,0.024820711,0.037912644,0.060067374,-0.012899959,0.009902697,-0.057399735,-0.01727965,0.019780459,0.037746288,-0.06339632,-0.011868915,-0.0012868907,0.0326157,0.029196065,0.04398705,-0.07203594,-0.073008336,0.061846543,-0.009717306,0.08078848,0.037106268,-0.003268036,-0.0498951,0.086052164,0.01097913,-0.03532898,-0.0684928,0.035468586,0.0021772636,-0.033677943,-0.009891039,0.049196403,0.03125003,-0.06576284,0.026466157,-0.05651081,0.013304283,0.07473179,-0.08153434,3.224254e-33,0.052104864,-0.0105497455,0.01861396,-0.043437567,-0.019211648,0.0076950626,-0.10694907,0.04377506,-0.061377138,-0.100208476,-0.15739731,-0.024717854,0.026107369,0.048729043,0.0362835,0.06621031,-0.0045671216,-0.03859108,0.11091791,0.0778579,0.029988352,-0.0025804932,-0.038507205,-0.02514059,-0.019657169,0.05193372,0.012998358,0.09313116,-0.02578233,0.005125551,0.04535572,-0.026891014,0.0010381412,0.052712075,0.120024286,0.057993934,0.02484717,-0.06385783,-0.044664115,0.060727764,0.013104983,0.037038054,-0.004104406,-0.06960739,0.061478373,-0.010594716,0.029983269,0.0062268064,0.046340708,0.114109784,-0.039834168,0.012022415,0.0708483,0.092661485,-0.02240503,0.08912486,0.051195625,0.0058083776,0.030289868,0.011048011,-0.02761897,0.07892359,0.00901682,-0.015445147,0.0042624287,0.059854813,-0.09914889,-0.053741116,-0.00710823,0.045559745,-0.00934132,-0.07451141,0.0069964994,0.06607854,0.0748805,-0.08358799,-0.00017354605,-0.02015669,-0.0359443,0.0023493273,0.11239273,-0.049154676,0.063311815,-0.058746155,-0.04056355,0.033080813,-0.09089311,-0.05492213,-0.0051293555,-0.008073604,0.043124292,-0.038967233,-0.061416544,0.005983501,-0.042072937,-4.2088336e-33,0.027344575,-0.067971356,0.034123562,-0.027764088,-0.088537104,0.024765808,-0.012991548,-0.14653265,0.052024625,-0.034666423,0.056176394,0.017371695,0.03592031,-0.034980226,0.018340759,0.06274237,-0.018422153,0.051744636,-0.023988176,-0.031644292,0.0022750194,0.063225485,0.024669038,-0.060244385,0.04419733,-0.043035876,6.071809e-05,0.14269824,0.024358563,-0.020779798,-0.006669443,-0.07629244,-0.08881163,-0.023558892,0.0075103203,-0.027221669,-0.087240174,-0.013588824,0.013754572,0.029517895,0.050414164,0.08190705,0.043304,0.031853642,0.062225554,0.006117284,-0.07702057,0.040170603,0.0070000915,-0.048793223,-0.031012403,0.034962296,-0.04036105,0.0065510734,0.10054581,0.011790999,0.041319206,0.033590827,-0.048942693,-0.0036722235,-0.042281404,-0.05674952,-0.002901566,0.005057142,0.08686851,0.07532594,0.025455898,0.032802068,0.04195434,0.07863826,0.04542008,-0.07365294,-0.010113451,0.03807576,-0.05705331,-0.010970838,-0.10946978,-0.0011096527,-0.03526872,-0.010114928,0.06346794,-0.013740656,0.009256248,-0.10139146,-0.011423133,-0.089961685,-0.032451317,0.056207463,0.030973375,0.08621535,0.080880694,0.032807168,0.039816774,-0.011818959,0.06678429,-3.4533564e-08,0.02868246,-0.0884087,0.039825704,-0.018736225,0.034672454,-0.023405643,0.0026500553,-0.072633594,0.023239119,0.0082451375,-0.035576534,0.077264525,-0.036814112,0.023782697,-0.036062945,0.053450137,0.005950023,0.048324134,-0.0022545338,0.13007714,-0.08136008,-0.011766163,-0.079275645,0.064043425,0.02076708,-0.104115434,0.009084985,0.054379407,0.00086936133,0.029871384,-0.006077942,0.03390796,0.06539354,-0.04882844,-0.13280141,0.008497958,-0.035515685,0.025702678,-0.06339759,-0.01553814,0.043795817,-0.076166876,0.032083586,-0.0025353935,-0.0353222,0.013928045,0.017294345,-0.0042034606,-0.005131979,0.010665142,0.0486001,-0.008243036,-0.01616145,-0.09237036,-0.00011649317,-0.056634836,0.03440683,-0.04690634,0.0022720199,-0.0030669926,-0.050415296,0.037990164,0.10593044,-0.042748008 +2.4.1.331,Isolated from Streptomyces olivaceus Tu2353. Involved in elloramycin biosynthesis. In vitro it can also utilize other 6-deoxy D- or L-hexoses.,384,1.0,-0.03693437,-0.030331187,-0.15373702,-0.02180198,0.0331433,0.023970395,-0.02709517,0.040273316,0.08122343,-0.053107686,0.024469139,-0.0088452725,0.08885532,-0.033026062,-0.034717895,0.0014131921,-0.024733135,-0.0050831996,-0.017600676,-0.043599088,0.088588305,0.09205711,0.018358072,-0.06291171,0.07766141,0.012087367,-0.0034781953,-0.0011982952,-0.035345178,-0.11195251,0.07501411,0.0007977907,0.07090334,-0.08343381,0.11737143,0.08370414,-0.06305369,-0.018669993,0.12604643,0.03415385,-0.044234704,0.00032592425,0.019901918,-0.006549856,-0.099963285,0.0074544232,-0.04716636,0.020929413,0.05223051,-0.021976896,0.04033835,-0.054691195,-0.046790045,0.04383728,0.04137288,0.000667385,-0.014940764,-0.035381928,0.002669766,-0.026343947,0.12195156,-0.02679699,0.06839504,0.017397124,-0.10640367,-0.015723636,0.06074605,-0.07893183,0.05838477,-0.075107425,-0.036311734,0.063976154,-0.007566012,0.06686979,0.026954997,0.035293184,0.038347635,-0.062370006,-0.050695922,0.028957961,0.034377094,0.015365707,0.028233515,0.08805217,0.01281433,-0.052254688,0.046498336,0.045816407,0.04719508,0.044660706,-0.013306556,0.043475382,-0.02998206,-0.096391566,0.0047466094,-0.05484629,-0.0741531,0.021208527,-0.0541086,-0.004712507,-0.020048572,0.052022748,0.048983913,0.007736242,-0.0018253045,0.0058616945,-0.01774494,0.04096328,0.0007936749,-0.10085487,0.031127727,-0.058841538,0.076045536,-0.105340265,-0.005935213,0.0733954,0.102363184,-0.0943772,-0.054668553,-0.047172226,0.050206322,0.0037008328,0.042903148,-0.005226793,-0.0034157778,0.06587879,-0.05220625,1.5939544e-33,-0.021802802,0.058017924,0.01303583,0.008071816,0.047444798,0.027504582,-0.020065382,-0.03632941,-0.038706794,-0.10131201,-0.10070789,-0.061305244,0.029216962,0.0130501,0.04251006,0.02419734,0.06311061,0.0022479682,-0.007042886,0.01684724,0.041159526,0.021626616,-0.028359283,0.009243029,0.011754109,-0.0045454875,-0.008864918,-0.016801918,0.131903,-0.024465684,0.00066695386,-0.027919054,-0.041943185,-0.0010535872,0.039915416,0.008712606,-0.07600689,-0.02466499,0.08536929,0.026922872,0.0018687304,0.07541174,0.042977877,0.0148591725,0.036317732,-0.017359518,-0.052328322,0.044186983,0.09922884,0.014989596,0.023947617,0.0016631713,0.03688456,-0.099058695,-0.05184615,-0.023239765,-0.018723883,0.06204584,0.04857279,0.09216412,0.05800306,0.035434376,-0.00065384223,0.07196237,0.096539274,-0.020798348,-0.0142657645,-0.040857248,-0.097405806,-0.034328844,-0.07338847,-0.0646804,0.035891954,-0.059813987,0.039753757,-0.026551036,-0.018176088,-0.064367615,0.052186966,-0.0022908873,-0.0016755279,-0.006400068,-0.012347563,-0.06781515,-0.066697076,0.044345737,-0.06769605,-0.012391368,0.03409921,0.11485816,-0.06421119,-0.055909827,-0.17216493,-0.009756952,0.009039882,-3.0588804e-33,0.06491291,-0.028670313,0.059753574,-0.048972666,-0.057991963,0.16212842,-0.038295887,0.053542897,-0.0067396415,-0.013426564,0.09463234,0.02530198,-0.024773194,-0.073865056,0.016579451,-0.046936598,0.012361433,0.11263986,-0.039299972,0.08444159,0.008832668,0.058859874,-0.020576756,-0.0118327625,0.06714938,0.01445443,-0.011356272,0.008612563,-0.0015853856,0.019468473,-0.021368202,-0.022686206,-0.03564634,-0.004991878,-0.07173057,0.069314085,-0.047949657,-0.054739825,0.06895206,-0.014217196,-0.027672725,-0.014099202,0.033045217,0.033932388,0.011538341,-0.0027600357,-0.09801246,0.03085974,0.015142007,-0.018453052,-0.0005335631,0.011568149,-0.0673626,-0.022050502,0.011604616,-0.030065319,0.018254926,0.014937902,-0.023395585,-0.03838683,0.00545237,0.009685962,-0.015229111,0.0042886776,0.059178106,0.07622087,-0.033620927,0.053179614,0.026635937,-0.06390805,-0.0152915185,0.007278059,-0.042265225,-0.006636587,0.05457116,0.011582159,-0.09210463,-0.01921487,-0.014082811,0.031339478,-0.0029059495,-0.048123274,0.06754911,-0.014895163,0.011635165,-0.059631497,0.047625836,-0.018372208,0.041281033,0.031102967,-0.041753642,0.010913661,-0.040388223,-0.00050657784,0.054701913,-3.1021298e-08,0.06863157,-0.03580719,0.07373118,-0.022114933,-0.027560653,-0.038185284,0.00016298491,-0.039693084,0.004396317,0.024795465,-0.06793997,-0.0051770224,0.03380563,-0.069284745,0.0012876726,0.032576147,-0.046441264,0.030832706,0.023280688,0.0011976148,-0.050329033,-0.038672842,-0.021861196,0.05270293,0.03897398,-0.07718327,0.040567152,-0.033733904,0.05907858,-0.00615672,0.037398778,-0.06915328,-0.080721825,-0.05330377,-0.036406685,-0.020964632,-0.09518581,-0.030792842,0.025804542,0.013541024,-0.0034797443,0.008403257,-0.06303799,0.008749322,-0.095450304,0.04654079,-0.005861144,-0.051964156,-0.08207527,-0.014252838,0.027509639,-0.021294717,0.046703354,0.014949145,-0.09413393,-0.0013519784,0.032491077,-0.063069254,-0.006414145,-0.05867728,-0.061755147,-0.003390288,0.17372261,0.008271654 +2.5.1.124,"The enzyme is involved in biosynthesis of the polyketide-isoprenoid furaquinocin D in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 6-linalyl-2-O,3-dimethylflaviolin and 7-O-geranyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.125, 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase) in a 10:1 ratio.",384,0.9999999,-0.010158687,0.023227986,-0.15254162,0.032011885,0.0031525537,0.07649256,-0.07510104,0.039278533,0.10250967,-0.036391433,-0.016423509,-0.03933045,-0.05943439,0.013737371,-0.0720665,-0.050856505,-0.061381932,0.061757818,-0.0040522884,-0.009404672,0.05793582,0.012578107,0.025313715,-0.01346833,0.06757258,-0.04336701,0.034610085,-0.040974583,-0.017991485,0.04816637,0.03791722,-0.07141643,0.044290837,-0.0399439,0.057423096,0.0984533,0.016981108,-0.084876984,0.1025731,0.07102809,0.038791258,-0.0020983384,0.013961358,0.055480596,-0.09320157,0.022831263,-0.020962432,0.033417083,0.0082499515,-0.07952143,-0.10640808,-0.07584047,-0.1010287,0.031247206,0.050206825,-0.01672255,-0.018691026,-0.013653128,0.013165203,-0.06699644,0.07330685,-0.035936065,0.07256232,-0.005764142,-0.06713474,-0.044949006,0.055611555,-0.04656652,0.04011317,-0.02601087,-0.052523118,0.029663667,-0.01122071,0.007299161,-0.011094112,0.077665456,-0.0647898,0.014673095,-0.046078946,-0.05358693,0.071883306,0.023108508,-0.005097992,0.08184921,0.0056119086,0.005793009,0.04925099,0.0402784,0.06003326,0.068477854,0.07957253,-0.021536604,0.038441412,-0.10091142,-0.04664979,-0.015275298,-0.011607224,0.06723102,0.034414478,-0.012643151,-0.06563735,0.00899225,-0.019861544,-0.019701062,-0.0072618797,-0.022215784,-0.031900745,0.09465696,0.065137155,-0.021821396,-0.030202629,0.036218144,-0.021802565,0.00866722,-0.016511515,0.048046123,0.06711141,-0.03124787,-0.07614055,0.011153485,-0.0057194736,-0.016147336,0.06797245,0.05194932,-0.04177558,0.0061021834,-0.069080465,2.192669e-33,0.055319183,0.036960974,0.07499114,-0.008850271,-0.023565603,-0.020507965,-0.11032231,-0.013835584,-0.012160008,-0.011142539,-0.10944132,-0.07963806,-0.0064961025,0.05052913,0.046430804,-0.017475216,-0.023533087,0.024380106,0.10461936,-0.043753587,0.01809538,-0.00091888965,-0.020149281,0.0025829233,0.010174434,0.07565211,0.005951355,0.011552829,0.029924607,-0.030023536,-0.0031625428,-0.08628415,-0.062153317,-0.0007079982,0.045230445,-0.027785651,-0.0727796,-0.061450403,0.05645631,0.021964964,-0.043790337,-0.006695055,0.032582253,-0.030771406,0.07131604,-0.0073649166,-0.05988626,0.039972782,0.06072212,0.047711387,-0.017063808,-0.0039442712,0.09147658,0.010374314,-0.110322334,-0.06011519,0.0509875,-0.030420052,0.047945894,0.035794448,0.00046019745,0.026220484,0.031506196,-0.060082417,0.026300048,-0.012045542,-0.028834479,0.006691207,-0.0050317594,0.03935762,0.0038231744,-0.04788917,-0.0027155026,0.036190137,0.011120591,0.023769911,-0.07495354,-0.07540273,0.044696048,-0.012068702,-0.04133846,0.05164725,-0.033386912,-0.09673257,-0.03227568,0.064423464,-0.05339563,-0.0678557,-0.05197014,0.119614236,-0.011804921,-0.03021709,-0.09019407,0.03504281,0.019446693,-3.5834828e-33,0.11030899,-0.104712084,-0.0036182909,-0.091145314,-0.08338176,0.07719014,-0.04419229,0.03883475,-0.025513068,-0.028271658,0.0731829,-0.029391002,-0.00600594,-0.009283182,-0.007794021,-0.034662288,0.0025057013,0.067676,0.007510236,-0.023100857,0.047705784,0.000108824635,-0.01666092,0.031692836,0.042031776,0.01922801,0.04925448,0.097257935,0.0074759545,0.11186765,0.023180943,-0.07818058,-0.07779791,0.030010238,-0.03537869,0.050036576,-0.055678997,0.061332405,0.05990223,0.010901194,0.0045810626,-0.01646097,0.022612024,0.035987813,0.056876723,0.08400807,-0.012386431,0.03280139,0.025906414,-0.027356379,0.039765105,0.026658881,-0.0210215,0.02283842,0.031576294,0.05780784,-0.003973328,-0.03669044,-0.012781981,-0.10190036,-0.0171403,-0.016990066,0.058186974,-0.015168746,0.019329999,0.102609225,0.02851197,0.06699591,0.053682715,-0.056999587,0.067776166,-0.0036918349,-0.028222458,0.011606477,-0.07332912,-0.046628036,-0.066226475,-0.012852238,0.011163813,0.007990167,0.0096499985,-0.036663402,-0.0040107425,-0.049078427,-0.035076536,-0.063593104,0.1440858,0.07464457,-0.01223011,0.073970415,-0.04680421,0.08288775,-0.010339904,0.025599454,0.07794983,-4.9107673e-08,-0.019559111,-0.025261804,0.07236535,-0.025132261,0.05878401,-0.05821247,-0.067578524,-0.02727062,-0.0033816688,0.0073094843,-0.031635057,0.019412894,-0.01101959,0.0064134034,-0.0022145484,0.008015411,-0.09943162,-0.023386337,0.022775406,-0.03504984,-0.057767205,-0.032623593,-0.053012095,-0.025503306,0.0070968596,-0.121671975,0.01194454,0.0692457,0.01580219,0.004559321,0.061971013,-0.013906713,-0.048900954,0.03129324,-0.02307438,0.008639024,-0.11627699,-0.074619055,0.039150834,-0.038730964,-0.0024499793,-0.02526538,-0.03067334,0.056342144,-0.024234345,0.045961414,0.004635567,0.025115225,-0.09502154,0.025069294,0.13237505,0.0200057,0.0077328975,0.028450802,-0.102062404,0.016508684,-0.01336112,-0.01208794,-0.07835187,0.025277564,-0.0353336,-0.02687468,0.16294159,-0.011159613 +2.5.1.125,"The enzyme is involved in furaquinocin biosynthesis in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 7-O-geranyl-2-O,3-dimethylflaviolin and 6-linalyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.124, 6-linalyl-2-O,3-dimethylflaviolin synthase) in a 1:10 ratio. ",384,1.0,-0.04493566,-0.0053462316,-0.2235571,0.037156347,-4.3572774e-05,0.07495687,-0.080057934,0.057900626,0.081969224,-0.04519622,-0.0027638252,-0.0415114,-0.087107874,0.02833889,-0.054884,-0.049732845,-0.07539011,0.056260277,-0.036501393,-0.007953216,0.05729194,0.027790515,0.04797218,0.018794945,0.07254427,-0.026556669,0.008645455,-0.019414298,-0.0045462167,0.012283322,0.019870816,-0.051217925,0.05805628,-0.034961823,0.055754866,0.052009374,0.0131628625,-0.10511406,0.09457703,0.049929753,0.033724938,0.016798584,0.0002675385,0.050108902,-0.0954853,0.0026935295,0.015789188,0.03557033,0.02045715,-0.04545098,-0.10979902,-0.0828013,-0.12958926,0.045300655,0.021845559,-0.026663322,-0.032485228,-0.035273366,-0.0015039083,-0.012090493,0.06577978,-0.022366991,0.05892853,0.012771871,-0.06868905,-0.052911997,0.039728012,-0.07156296,0.014388338,-0.03473654,-0.041913047,-0.03546682,0.010288218,0.025235994,-0.019903861,0.10845009,-0.063449375,0.044587802,-0.049732342,-0.046504162,0.08813856,-0.014881092,-0.034068145,0.10329086,0.00013995329,-0.033178214,0.039454583,0.03554713,0.06413923,0.0694623,0.094821066,-0.00793113,0.032249995,-0.12724195,-0.040009696,0.014144899,-0.015296774,0.049834676,0.025364136,-0.015568379,-0.04287625,0.010675927,0.017195359,-0.014663199,0.0019140699,0.005008529,-0.038234446,0.11167545,0.070854805,-0.042428937,-0.025308711,0.010403836,-0.029788317,0.014282542,-0.016958853,0.05282031,0.08324203,-0.04921378,-0.08956509,0.06710612,0.03182104,-0.009759538,0.06596031,0.03213208,-0.021654692,0.0018706414,-0.043435838,2.373098e-33,0.060026158,0.04766321,0.02734592,-0.037683856,-0.0014364773,-0.011886014,-0.1143321,-0.0021866607,-0.008945606,0.019083446,-0.08943893,-0.07338815,0.018950148,0.023052653,0.024538388,-0.031296544,-0.006951001,-0.0027794559,0.080762275,-0.0016339351,0.05867655,0.024388684,-0.017263692,0.015733005,0.027844002,0.091022074,-0.008276173,0.0055308957,0.02631205,-0.027890317,0.054339457,-0.08327869,-0.08008419,-0.017113402,0.05409101,-0.040055756,-0.08646481,-0.069026776,0.07843064,0.022503713,-0.033430982,-0.029124679,0.0043432917,-0.0034244987,0.064006396,0.006192687,-0.050915614,0.03836379,0.04351138,0.01897622,0.005797753,-0.017511066,0.09510996,0.035301365,-0.057193995,-0.03760842,0.046917804,0.006585348,0.056005765,0.02951506,0.014072616,0.012783201,0.00507229,-0.054529447,0.018207887,-0.019189488,-0.022208665,0.024129076,-0.024406223,0.025295628,0.0030581334,-0.03697964,-0.019821983,0.030333946,0.0038378306,0.036310624,-0.06637442,-0.05202962,0.00931703,-0.031654447,-0.021863999,0.04020142,-0.006136609,-0.03158602,-0.05762176,0.054002546,-0.083098695,-0.051198784,-0.0857467,0.07304896,-0.012401208,0.008976088,-0.07599069,0.010296098,0.02824233,-3.7764655e-33,0.1277567,-0.11319987,0.0147788115,-0.07563768,-0.09247465,0.09705938,-0.040325604,0.026255004,-0.03867433,-0.0036230255,0.069256715,-0.01939862,-0.0040258067,-0.05791005,-0.019268228,-0.020215102,-0.019741926,0.087895386,-0.0066969157,-0.037452977,0.053747706,0.0032131232,-0.011872786,0.017799163,0.04538417,0.0059873285,0.032528095,0.06210318,0.030231759,0.09864525,0.025171826,-0.10832358,-0.092267245,-0.03320003,-0.051506974,0.05156467,-0.014724421,0.049574476,0.052795,-0.0029773815,0.036022823,-0.009462148,0.036379162,0.0051445006,0.06609589,0.06933162,0.006035821,0.012974471,0.021927657,-0.007773731,0.05260676,0.040404078,-0.023753861,0.032120716,0.031456925,0.045888823,0.052924957,-0.094633445,-0.0063688694,-0.06950797,-0.043892376,-0.034488294,0.043260526,-0.0184092,0.014502467,0.08180864,0.023527708,0.065759026,0.06647915,-0.034130827,0.08457288,-0.0137866,-0.032338325,0.022177128,-0.06730586,0.014398953,-0.04951016,-0.03135335,0.023663078,-0.0034000967,0.018462896,-0.043031905,-0.0066201696,-0.026593864,-0.023379711,-0.09103679,0.1385955,0.082841,0.01569507,0.04657376,-0.045280974,0.034195814,0.014129581,-0.003253386,0.06589334,-4.3755737e-08,-0.006184613,-0.047930114,0.070489064,-0.00822621,0.09893617,-0.010396099,-0.06623695,0.0024138675,0.006373755,0.015309306,-0.023736797,0.0008036381,-0.012536799,0.0068412605,-0.0061928257,0.019907568,-0.068528816,-0.015088041,0.052889805,-0.04874543,-0.03880483,-0.050498396,-0.05003507,-0.00035156042,0.013153435,-0.11597962,-0.021684164,0.0834651,0.0018562258,0.001582701,0.043700565,-0.0009305226,-0.01379896,0.009443415,-0.058980342,-0.058441494,-0.11605987,-0.08024116,0.008923298,-0.051581137,-0.019357666,-0.0014256192,-0.034049794,0.02661958,-0.028717088,0.06223425,0.026060307,0.025042454,-0.08002383,0.010640773,0.12598678,0.023964774,-0.005753458,0.044551425,-0.10912334,-0.003490464,0.017357592,-0.037082627,-0.07082468,0.026088258,-0.04147334,-0.014752657,0.14243108,-0.027394168 +2.5.1.126,"The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.127, caldopentamine synthase, this enzyme does not accept norspermine as a substrate.",384,1.0,0.008142929,-0.044571433,-0.06606131,-0.06798076,0.029785281,0.012011782,-0.061992828,0.010874567,0.002288332,0.018117737,0.005755868,-0.023567118,-0.04660483,0.053114858,0.023817088,0.02217336,-0.027698934,-0.017335901,0.044413283,0.013610522,0.09757764,0.034703862,0.028204031,0.004836862,-0.042799015,0.019852892,0.007934041,0.017689783,0.018864311,-0.029462459,0.013828725,-0.0194827,0.020799393,-0.056810796,0.09261685,0.008869916,-0.051155716,0.021047005,-0.06631238,0.0645932,0.07881987,0.04234918,-0.013590928,0.036252163,-0.06679968,-0.032880325,0.06468191,-0.0051283496,0.06435159,-0.004094951,-0.014027778,-0.024635278,0.012647681,-0.0075741136,0.002135782,0.09712944,-0.05252685,-0.017032355,-0.032580554,0.024568427,0.014753469,0.09943344,0.0029243866,-0.05895644,0.084623784,0.0048503694,0.0899257,-0.03940139,0.034113295,-0.043615837,-0.05269213,-0.042801734,0.040360015,0.05824751,-0.012701822,-0.01140094,0.0076712216,-0.031452004,0.070533805,-0.00048817217,-0.047954205,-0.15467551,-0.10570947,0.013279781,-0.01777337,0.06287395,0.048138093,0.023063585,0.08257784,-0.0022599513,-0.027790269,-0.033895366,0.05194482,-0.07949044,-0.045065366,-0.026988214,-0.00095126685,0.063046955,0.024895385,-0.07708301,0.004872594,0.050181974,-0.09011089,-0.07471322,-0.057234198,-0.0018829765,-0.0032121092,0.016238289,0.03205403,0.045780156,-0.0040217196,0.016499074,0.091527395,0.031629264,-0.06722073,0.047229342,-0.053038307,-0.040082593,-0.056036033,-0.0046448847,-0.009617616,0.0042837216,0.026389137,0.11384867,-0.047086008,0.016838713,-0.037466854,2.7192613e-33,0.039402433,0.08508689,0.0033165887,-0.0008200069,0.01453953,0.07876134,-0.02813507,-0.015155001,-0.027917324,-0.15519822,0.010481562,0.0020963072,0.044381738,0.0809904,0.0028508308,-0.03511617,-0.00070328586,0.00057238975,0.044800688,-0.004620047,-0.0051222644,0.033845305,-0.0069430214,0.02168599,0.03698336,0.031412665,-0.020820905,0.05474287,0.10834618,-0.031704254,-0.00072005496,-0.06997616,-0.080485456,0.05379167,0.08157725,0.016386114,-0.025571367,-0.025468297,-0.064523734,0.097608596,-0.093621075,0.028314553,0.03295898,-0.05055638,0.0038304073,-0.10538234,-0.057524584,0.13926466,-0.018801372,-0.028913658,-0.012520045,-0.002265058,0.011180397,-0.0215881,-0.059004933,-0.041329656,-0.007968123,-0.059848282,-0.017143153,-0.04182178,0.04660525,-0.00064067263,0.002965735,-0.003172906,0.05523313,0.0126680685,-0.031364422,-0.0027171692,0.08688836,0.057736926,-0.025255008,0.026894176,-0.00411753,0.013638812,0.008514367,-0.0020646725,-0.16708362,0.004256418,0.0392888,-0.027046692,0.01268147,-0.07201973,-0.0042370153,0.020270245,-0.033055503,-0.024969548,0.028874343,0.07501967,-0.0030302373,0.05245394,0.017315999,-0.14844933,0.025151277,0.010231064,-0.0014664531,-3.022116e-33,0.037032954,-0.07743577,0.015137366,-0.024966212,0.010706387,0.005592324,0.11094788,-0.018249331,-0.078424774,-0.122696206,0.034283593,-0.06034294,0.08863113,-0.09882885,0.013640681,0.02599435,0.01977849,0.09974529,0.026194468,-0.04816654,0.0058404114,-0.009732881,-0.08219616,0.09251319,0.019661626,-0.02855772,0.011542384,-0.023743842,-0.015879793,0.06334987,-0.043534398,0.06071716,-0.03472431,-0.053379603,0.011292495,0.07354067,-0.008339104,0.019291885,0.038591698,-0.07956768,-0.04922359,0.066602066,-0.016368525,0.027496396,-0.018284563,0.06716152,-0.052472997,0.0093719335,0.054446496,0.03731498,0.021991663,-0.02654042,0.0014266432,-0.043404497,0.036719117,-0.024648767,-0.014975558,-0.043916106,0.02456567,-0.04530017,-0.06791125,-0.059870943,0.015244016,-0.006480352,0.010484209,0.055111244,-0.060084667,0.08466083,0.031033931,-0.026106175,0.1071135,-0.012397223,0.1254463,0.04097868,-0.05299595,-0.06281176,0.0066967164,-0.0036441267,0.060063854,-0.04445279,-0.0029437905,-0.0025443153,0.01421534,-0.008654718,0.036395535,-0.016435292,0.07488633,0.05428603,-0.007266366,0.03073799,0.020261899,-0.049034584,-0.049440164,0.057173174,0.105394155,-3.964691e-08,0.07411641,-0.06047825,0.038142607,0.0060311607,-0.040260587,0.057195615,0.028737348,0.003979143,0.042211723,-0.04065255,0.041015107,0.061346713,0.03169353,0.026898256,0.04767731,-9.989603e-05,-0.0015835841,0.08109119,-0.026339414,-0.07013276,-0.057636835,-0.027521903,-0.12253229,0.015588042,-0.030458318,0.034438998,-0.025196943,-0.014621506,0.0525397,-0.032339312,-0.049962193,-0.052466407,-0.025720447,-0.095350035,-0.053742304,0.019789174,0.044188198,0.019671932,-0.021229252,-0.011752817,0.05938809,-0.00692149,-0.04877844,0.026346907,0.10856086,-0.07852778,-0.011736837,-0.0068341135,-0.043792676,0.061404333,0.08421519,-0.009109967,0.055756837,-0.07078481,-0.13046332,-0.03980173,-0.081926316,-0.0066642943,-0.077717766,0.010976874,0.035136655,0.01636834,0.16899054,-0.031514194 +2.5.1.127,"The enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.23, sym-norspermidine synthase and EC 2.5.1.126, norspermine synthase, this enzyme shows no activity with propane-1,3-diamine. ",384,0.99999994,-0.015756782,0.0035079767,-0.05493932,-0.06362718,0.042728394,0.013110797,-0.084790096,-0.027917905,-0.026114883,0.026823483,0.029529758,-0.009348105,-0.035176553,0.022840656,-0.0052041844,0.034258958,0.025897542,-0.0078086997,0.035233155,0.024759276,0.118388034,0.017752571,0.0124838045,-0.0064464477,-0.030037506,0.005625758,-0.028495064,0.029364247,0.0146190245,-0.07120556,-0.00087549805,-0.03590963,0.012133355,-0.02731995,0.062486287,0.01786793,-0.014922234,-0.001740103,-0.03244594,0.104518816,0.082647935,-0.012813957,-0.011984767,0.025635336,-0.06912334,-0.045212913,0.022262296,-0.013836995,0.054462273,-0.0044970713,-0.02670001,-0.04105503,0.051119342,-0.032497305,-0.031451702,0.08568254,-0.073810205,-0.019545812,-0.072299935,0.010769917,0.04547124,0.12505,-0.037240885,-0.03511917,0.071203485,-0.0034122514,0.07582109,-0.023782555,0.027939074,-0.048438776,-0.019334959,-0.072712086,0.03421392,0.04469846,-0.023299443,-0.011466503,0.015973477,-0.018966973,0.063775994,-0.015233232,-0.04482729,-0.14143835,-0.10107385,0.014417244,-0.007563186,0.046057694,0.06751466,0.02595819,0.061074518,-0.03788636,-0.034685675,-0.051490817,0.04432046,-0.058125984,-0.028901206,0.018529098,0.002316788,0.08792258,0.04202554,-0.072666205,-0.006420438,0.025116203,-0.08994235,-0.08376316,-0.0143736815,-0.035013985,-0.024965804,0.03231651,0.094632536,0.033915885,-0.025261529,0.016745856,0.07760483,0.08641436,-0.05639653,0.032520484,-0.063748926,-0.04071702,-0.052094888,-0.0018723111,0.035823133,0.010429141,0.033679433,0.12720916,-0.0059432155,0.060025893,-0.029314872,2.4194414e-33,0.06122832,0.055296175,0.0028101108,0.0016672784,0.01619808,0.09943568,-0.017038418,-0.0026693363,-0.044829823,-0.11725157,-0.010289427,-0.005058376,0.06326761,0.08499022,0.0010362957,-0.0435587,0.03871421,-0.02217167,0.06197955,0.0012422188,-0.04124946,0.05324251,-0.01997737,0.03060333,0.054687567,0.01416554,-0.007368194,0.016394591,0.10903532,-0.035053186,0.023186058,-0.110505946,-0.064372204,0.075270616,0.06681984,0.052621093,-0.038393926,-0.023726098,-0.052788716,0.05821778,-0.0497439,0.043554496,0.032507665,-0.07529472,0.0023007446,-0.08839096,-0.062324967,0.12907396,-0.0328158,-0.030432986,-0.02542844,0.02386147,0.04647316,-0.021745382,-0.046447482,-0.020358162,-0.012526835,-0.0047312337,-0.047877684,-0.02763477,0.0019118715,-0.0075021344,0.006456251,-0.0057302415,0.077550605,0.013662095,-0.044485573,-0.0061070556,0.07157535,0.058903985,-0.023568556,0.026215192,0.004362858,0.0027400535,0.00565333,0.0005288378,-0.13671833,0.024052577,0.047618177,-0.037853427,0.017951474,-0.026271872,-0.0062592966,0.039222673,-0.05166317,-0.0075736823,0.025554385,0.06897071,0.03497363,0.065457605,0.06052607,-0.1506725,-0.009248443,-0.032905336,0.032491136,-2.2628933e-33,0.0384532,-0.08381021,0.01072448,0.008268023,0.029017016,0.014891644,0.09148567,0.00924286,-0.09428604,-0.09430458,0.06568666,-0.045689467,0.06499467,-0.11582926,0.0043299715,0.042653214,0.012732019,0.111962594,0.03158881,-0.025570307,-0.026217328,0.006947835,-0.047445826,0.08774003,0.009982944,-0.019999523,0.0135226445,-0.0070028272,-0.04333933,0.04529755,0.0035092982,0.08867281,-0.048538983,-0.063489966,0.03662382,0.10661741,-0.037213728,0.018161556,0.045720153,-0.070510425,-0.06345284,0.06478829,0.011878499,0.0017395754,0.03428492,0.07316706,-0.053106077,-0.01888031,0.0013319332,0.03976269,-0.0006673259,-0.057670012,0.014176016,-0.057083536,0.031643208,-0.04433713,-0.04613997,-0.04489689,0.016183184,-0.062732294,-0.040676527,-0.01905464,-0.033984534,0.017865416,-0.034652986,0.042868525,-0.07629939,0.06705788,0.023512475,-0.010743425,0.105657734,-0.032253034,0.0965769,0.022619773,-0.05237191,-0.05188293,-0.02104705,0.0028629852,0.052608144,-0.057411786,-0.011550618,-0.0011509287,-0.0013042107,-0.0038508642,0.014018586,0.0018956474,0.08043026,0.09140322,-0.008653323,0.048829347,0.024683252,-0.05486988,-0.05498854,0.061970744,0.12094659,-4.0333834e-08,0.10695042,-0.07435632,0.053768754,-0.012720911,-0.043938275,0.06844451,0.022673644,-0.0008730327,0.048697945,-0.02025685,0.034207452,0.058454357,0.037004344,0.011624267,0.030719727,-0.0325886,0.064358234,0.07556533,-0.03054695,-0.05210287,-0.06565022,-0.014584637,-0.103640154,0.021680295,-0.0072124884,0.02674954,0.020030651,-0.020096032,0.076747514,-0.036478043,-0.054740675,-0.018070642,-0.022204772,-0.0766297,-0.057628673,0.016612075,0.053828854,0.032256708,0.026263095,0.00077040103,0.043234296,-0.022271955,-0.061381415,0.021350972,0.08485478,-0.099569455,0.002847735,-0.028145358,-0.035588924,0.019503653,0.03170124,-0.034556296,0.06252869,-0.101069964,-0.11536137,-0.047133192,-0.07103425,0.012830161,-0.062389903,0.009723247,0.027780663,0.011893104,0.13876614,-0.027389383 +2.7.1.185,"Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea. 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+2.7.1.186,Mevalonate 3-kinase (EC 2.7.1.185) and mevalonate-3-phosphate-5-kinase act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. 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+2.7.14.1,"The enzyme, characterized from Gram-positive bacteria, is involved in the regulation of the bacterial stress response.",384,1.0,-0.08804422,-0.07481996,-0.07308352,0.0316401,0.033241503,0.07436154,-0.044325557,0.08954402,-0.0036565368,0.010010795,0.0026117105,-0.055957943,0.011679046,0.06495968,-0.026358034,0.027395157,-0.055925112,0.039186124,-0.020184262,-0.044704687,0.11338144,0.05472626,-0.056708325,-0.015137512,0.029336972,0.018698726,0.08235641,0.0036478254,0.009322038,-0.032941747,-0.026663307,-0.056468703,0.10438825,-0.038772885,0.058311407,0.10880868,-0.049008094,-0.086367264,0.07169483,-0.05291604,-0.046375774,0.016494142,-0.0063621188,-0.03364274,-0.014916435,0.022192914,0.08954154,0.061580345,0.047473304,-0.061839353,-0.035613712,-0.010497135,-0.02572051,-0.0313943,0.030645158,-0.0015651998,0.023328248,-0.072050445,-0.07222546,-0.016943999,-0.0212352,-0.0378756,0.027757496,0.050524842,0.039637208,-0.046045296,0.015264018,-0.004548602,-0.018413207,-0.029220132,-0.08294121,-0.06590048,0.03983981,0.048890766,0.010551872,0.009052295,-0.033164423,-0.0075194254,0.055457946,0.0016189588,0.096914105,-0.029780421,0.014940672,0.10098618,-0.01761963,-0.08515909,0.10478427,0.019900933,0.07381055,0.088501126,0.055262607,-0.059070643,-0.012472012,-0.0461388,-0.05549858,-0.016157642,-0.05128621,0.0004024715,0.02092777,-0.06254535,0.005803231,0.021436224,0.021307444,-0.019777674,-0.07662263,-0.03324994,0.008613448,0.061047044,0.059789713,0.047377523,0.026512545,0.049974617,0.041658647,-0.07307256,-0.08160699,0.025810476,0.023157239,-0.06516428,-0.055890687,0.032536488,-0.019405955,-0.052852523,-0.007032649,0.021751892,-0.050220422,0.05291615,-0.080315754,-5.7246843e-33,0.027513586,-0.009008137,-0.019751579,-0.06985486,-0.030761188,-0.029546557,-0.11118546,-0.009279402,-0.06772063,-0.053474933,-0.040752742,-0.101476,0.033634834,-0.0030123629,-0.021642193,0.040646687,-0.056554448,0.025405318,0.015810875,0.021503456,-0.084109396,-0.030488856,-0.014176598,-0.011768172,0.044832487,0.020155268,0.05659516,0.013684009,-0.05408782,-0.039031696,-0.016328461,-0.07708287,-0.05511516,0.014597113,0.10419151,0.01801332,-0.0036258576,-0.029197844,0.01965739,-0.015506141,-0.008734931,0.06338168,0.012732174,0.04233709,0.08889095,-0.020770455,-0.055120956,0.070672594,-0.02311739,0.09041897,0.08256379,-0.002678021,0.05942103,-0.04042601,-0.030936712,0.0489362,-0.009364448,0.0077873175,-0.021612832,0.020001564,-0.015872698,0.020279879,-0.06769883,0.012722192,0.031015292,0.0455469,-0.017264334,-0.023293696,0.009171029,0.13355586,-0.05799121,-0.015353272,-0.00085406116,0.007129161,-0.024126211,0.005319639,-0.09222004,0.0007641669,0.020019948,-0.049576875,-0.043245494,-0.064730264,-0.004893471,-0.004591374,-0.098099634,-0.0012248371,-0.029562727,-0.031968273,-0.021039296,-0.030196602,0.11823315,-0.053870123,-0.07142916,0.13322492,-0.0067742486,2.3444772e-33,0.07352658,-0.13926557,-0.03992956,-0.0689489,0.0129579315,0.078037284,-0.03160812,0.017535077,0.012454785,0.03165867,0.067210294,-0.037745327,-0.052878466,0.05569499,0.013305852,-0.0072721625,-0.052565284,0.08282531,-0.05802537,0.005686606,-0.0014138008,0.083323695,0.034760017,0.01414729,0.03733949,0.013957879,-0.070835724,0.11121652,0.01967944,0.09009163,0.037743244,0.024266273,-0.038662154,0.013358519,0.03286296,0.0045975493,0.023580246,-0.0036007976,0.02205647,-0.004687509,0.061120078,0.116524495,0.037307046,0.06362538,0.004530628,0.062421627,0.007563792,-0.026492352,-0.0049546943,-0.057443324,-0.037803773,-0.04771339,0.05193543,0.019167671,-0.005837692,-0.0034121345,-0.06270448,-0.023792826,-0.051051416,-0.023896616,-0.0978344,-0.068593346,0.051155005,-0.013618598,-0.00039331944,0.012377351,0.020229654,-0.021950325,0.058627263,-0.023591166,0.016715417,0.05588178,0.017643413,0.033116452,-0.07070103,-0.019801965,-0.097404845,-0.061001744,0.030967971,-0.013147229,0.01854204,0.04009265,-0.049023412,-0.02656627,-0.026669532,-0.02422114,-0.011389513,0.14566758,0.079463996,0.061176974,-0.044428803,0.045920942,-0.0733001,-0.02526384,0.03700363,-2.5923903e-08,0.011090429,-0.05977638,0.015772449,-0.04164376,0.03555394,0.06621195,0.0075820033,-0.0072885966,0.06882763,-0.004492003,0.0023463517,0.056157958,-0.064455986,0.012296053,-0.0028484922,0.016880382,-0.05988018,-0.020751888,-0.00080517936,-0.012801828,-0.03239812,-0.04621545,-0.056312326,0.11757945,0.074398,-0.065202236,0.056322586,0.047538593,-0.020955674,-0.043968327,-0.009134022,0.045862798,-0.020816991,-0.038538896,-0.13073303,0.072469205,-0.017738836,-0.03524341,0.006498425,0.049246185,0.039764885,0.049565572,-0.100455225,-0.035097938,0.019454964,0.090317495,0.0099917725,0.049608134,-0.036754243,-0.07576429,-0.0020790154,-0.011776649,-0.02191279,0.0560518,-0.118852496,-0.002802012,-0.035463635,-0.02105725,0.032586444,-0.001361225,0.0533161,0.030809358,0.17059599,-0.040788326 +3.5.4.41,The enzyme from the archaeon Methanocaldococcus jannaschii is involved in the recycling of 5'-deoxyadenosine. 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+3.9.1.2,"The enzyme, characterized from Gram-positive bacteria, hydrolyses the phosphoramidate (P-N) bond of Nomega-phospho-L-arginine residues in proteins and peptides that were phosphorylated by EC 2.7.14.1, protein arginine kinase.",384,1.0,-0.04719949,-0.036237128,-0.112522684,-0.004176262,0.05515866,0.08439073,0.017677383,0.04316486,0.09039736,0.032143366,0.06643503,-0.025756948,-0.03528591,0.090697385,-0.07166255,0.027668811,-0.09386203,-0.0017979399,0.037884,0.0060986225,0.073670566,0.08087509,-0.09766568,-0.01914289,0.006154789,-0.011045279,0.06947648,-0.027566565,-0.0034865642,-0.077119686,0.044573564,-0.058524746,0.112593085,-0.04775831,0.09367896,0.1243089,-0.0061794827,-0.12769082,0.07053835,-0.046076167,0.06576643,0.024584014,0.001670889,-0.057476,0.008751836,0.075504474,0.072086416,0.08690569,0.066311605,-0.049073588,-0.03594744,-0.060735572,-0.048925195,-0.0158946,-0.043981265,0.06341324,-0.14114265,-0.03310247,-0.004215587,0.020340132,-0.0077721113,0.024965847,0.066476084,0.04040674,-0.01634173,-0.070013665,0.0860675,-0.06799274,0.0449064,0.009100062,-0.086489685,-0.024167163,0.049509216,0.036109637,-0.029095499,0.057550557,-0.033698663,-0.005913303,0.014336002,-0.06871478,0.013178394,-0.06701087,0.0045966445,0.06434728,-0.034164518,-0.06278562,-0.015087766,0.034761712,0.07362492,-0.016126454,0.04810129,-0.07619485,0.08056027,-0.023382165,-0.03291319,-0.018875573,-0.014867567,0.064484425,-0.035289265,0.009029014,-0.015926233,0.06589015,-0.022765232,-0.034998514,0.059917673,0.043351363,0.0007217496,0.011375166,0.056684855,0.015626807,-0.038129415,0.017999131,0.03125012,-0.059058525,-0.03089335,0.03587595,0.0015324967,-0.07578356,-0.07483684,0.01584222,-0.027163722,-0.08790691,0.0043493584,0.072667144,-0.09253555,0.080513254,-0.062583596,1.4413911e-33,0.01875508,0.008610721,0.11186892,-0.0782627,0.000780507,-0.07379183,-0.051479403,-0.05202321,0.029506106,-0.108398646,-0.049170617,-0.04592044,0.06375132,0.01309315,-0.018130846,0.025611367,-0.0153227635,0.04856985,0.046879515,0.06466104,-0.04236416,-0.008152518,0.0049082865,0.0033701884,0.082629114,0.018865919,0.017294245,-0.037709754,0.031688742,0.00020381095,0.006196688,-0.038633913,-0.049270973,0.016985046,0.054631826,-0.089560926,-0.022827944,-0.033616453,0.02948776,0.022935513,-0.06923634,-0.013777742,-0.028832337,-0.010679444,0.023431992,-0.039069805,-0.06788493,0.08751774,0.0019080947,0.059100203,0.009401252,-0.038072865,0.027317738,0.0048200106,-0.0422914,-0.0028690638,-0.03763462,0.012216982,0.051238846,-0.02983835,-0.0074455943,0.04495157,-0.027652074,-0.019846214,-0.035467435,0.021401435,-0.009281168,-0.04261489,0.019119106,0.091828205,-0.07807707,0.013924015,0.029247703,0.007650417,-0.038525667,-0.07850684,-0.04429831,-0.002549277,-0.011814643,0.1054495,0.025632992,0.007402577,0.04704273,-0.0052987332,-0.024677621,-0.048690643,0.035611127,0.011662142,0.03396587,0.005155425,0.044082556,-0.025331797,-0.06904679,0.084462136,-0.028929621,-2.4053482e-33,0.13334069,-0.07443184,0.011274222,0.0010752437,-0.04053125,0.041259736,0.014818539,0.06347199,0.040797714,-0.006608067,0.083440684,0.019661557,-0.012348532,-0.055250384,0.05530167,-0.04032901,0.024657076,0.09321475,-0.01766328,-0.026781408,-0.021732258,-0.007111994,-0.01371947,0.0005668425,0.04501106,0.0069409176,-0.07565385,0.06813088,-0.08144291,0.04555551,-0.012371859,0.0139432615,-0.043231804,-0.081667684,-0.009052155,0.0053830165,0.0010764445,-0.03256766,-4.3906468e-05,-0.056008853,0.07496209,0.07230015,0.052401036,0.016586734,0.017901346,0.089171536,-0.008217155,0.010271522,-0.0367382,-0.10127359,-0.005138645,-0.030500393,0.026207693,0.01410337,0.009648157,-0.0024372702,-0.004371454,0.105466135,-0.0026782888,-0.0103563145,-0.026760826,-0.14053014,0.03946148,0.008969902,0.02755888,0.0412447,-0.0051463656,0.04505073,0.015286427,0.00753458,-0.00126845,0.06630654,0.033528578,0.0930957,-0.023392595,0.015988559,-0.084844455,-0.07609965,0.02394746,-0.11734493,-0.017330768,-0.004929854,-0.070723355,-0.03917197,0.016487053,0.037386347,0.052972972,0.054939844,0.012823968,0.04759479,-0.051521465,-0.032045573,-0.085252225,0.0640245,0.030716844,-3.7564572e-08,0.057259243,-0.02928863,-0.011671638,-0.03880245,0.022997206,0.05658409,-0.017668962,0.03114352,0.05748048,-0.010781315,0.07949738,0.0074258624,-0.019917775,-0.017155746,-0.0042954283,0.052350525,-0.08279314,-0.00051112764,-0.008879027,0.020779833,-0.00026385652,0.020298263,-0.06656697,0.04315674,0.07862175,-0.039312135,0.07676921,0.057157487,-0.06660538,-0.071913585,-0.0052888133,-0.027049981,-0.051818587,0.002392726,-0.016305182,0.021979734,-0.07767435,-0.05320482,0.0025119428,0.06295015,-0.022635031,0.067418694,-0.059208546,-0.022048222,-0.009180092,0.08535664,0.050085437,0.0066497885,-0.08756283,-0.051159266,0.014158772,-0.03163166,-0.03971453,-0.09621328,-0.1400771,-0.04081258,-0.014554804,-0.06313168,0.0145814335,-0.06507951,0.029756255,-0.027610544,0.11229536,0.01268625 +4.1.1.99,"The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase.",384,1.0,0.029518588,-0.06084491,-0.040155407,-0.07394783,-0.0029600968,0.021041851,-0.031417612,0.035099242,0.07070802,-0.0038466016,-0.032014944,-0.14910828,0.014742733,0.072677806,-0.080830164,0.05730386,-0.063449234,-0.040524017,0.024810279,-0.0059112133,0.07486393,0.06021805,-0.068534814,0.00486776,-0.040553458,0.058069274,0.037157893,-0.04294176,-0.004240791,-0.091295965,0.03325917,-0.008866445,0.126736,-0.02290511,0.09206043,0.11336665,-0.038539268,-0.074318014,0.09095039,0.007248351,0.008907781,0.020165676,0.004316708,0.0025397604,-0.043395672,0.06479276,0.045297008,-0.020453388,0.03528655,0.029314538,-0.015708284,-0.004441667,-0.042944234,0.07403313,9.5280935e-05,0.047117885,-0.028043931,-0.0065306737,0.026664566,-0.043964308,0.058793396,0.0144423675,0.070541136,-0.0067595104,-0.009912735,-0.014737381,0.025165183,-0.018589409,0.057069436,-0.108773656,-0.021015434,-0.05717518,-0.034168985,-9.816362e-05,0.055766735,0.048754938,0.00773502,-0.093031995,0.005103231,-0.05566991,-0.007467122,-0.018966613,0.033665244,-0.0076157055,0.014274268,-0.02213223,0.058072656,-0.023650862,0.065257154,0.023805358,0.03019228,-0.082145855,-0.03492847,-0.061648272,-0.048627403,0.022485867,0.008402043,-0.015963478,0.032567017,-0.042901423,0.014788422,-0.018521886,-0.0568392,-0.06823957,-0.05252172,-0.03475201,0.025531352,0.045365468,0.012801456,0.0010751925,-0.0150346365,-0.040563386,0.07816705,-0.03859315,0.046700258,0.10679779,0.07226067,-0.043868735,-0.094644964,0.052375328,-0.02131406,-0.08241419,0.011152216,0.033547573,-0.07160226,0.068956,-0.16316415,2.8648314e-33,0.073278956,0.027353832,0.048076414,-0.016052729,0.007219319,-0.05577298,-0.059647504,0.007264001,-0.07249158,-0.17732215,-0.016981585,0.0035803774,0.035903625,-0.030817784,-0.04094963,-0.013479477,-0.059615,0.017640362,-0.032498788,-0.009263755,-0.038621556,0.015267274,-0.0070481272,0.013577688,0.053495128,0.033814423,0.011074653,0.0055897725,0.0670926,-0.005851625,0.008427498,-0.12064813,-0.0844699,-0.0046413327,0.12451977,0.09435216,0.00082112633,-0.022542471,-0.08223075,0.030281205,-0.04226698,0.015555263,-0.040573835,-0.041559484,0.05971935,-0.105745405,-0.03868453,0.047352657,0.017992234,0.008717888,-0.0042552073,-0.028716614,0.077875376,-0.0655263,-0.055339698,0.045984853,-0.022964466,-0.04259617,0.070927575,0.0062365616,0.043008056,0.034372505,-0.0722904,0.028495636,0.062292002,0.0017469046,-0.051673602,-0.00407465,0.052761998,0.052915774,-0.0928826,-0.047601547,0.008680092,0.0554749,-0.0017777297,-0.026726788,-0.08718197,-0.046533454,0.0022732697,0.005743239,0.037453692,-0.036076147,0.032513376,-0.04619421,-0.029861996,0.01870975,0.024109766,-0.07309473,-0.009696391,0.034563765,0.019952593,-0.057140913,0.016883232,0.03378656,-0.0590934,-3.6832143e-33,0.0846687,-0.12217617,-0.0035922965,-0.010232899,-0.0015044714,0.092334755,0.013823374,0.01126995,0.011077303,-0.014570318,0.08173747,0.0065282094,0.0073701763,-0.025566425,0.017838338,-0.015596571,0.116730444,0.086425364,0.027051607,0.018696215,0.0252897,0.04380811,0.011877444,0.0051612044,-0.07035709,0.027243383,-0.00071800326,0.02315472,0.048303444,0.044837877,-0.018150026,0.10833623,0.002025044,-0.038127903,-0.074907854,0.011620387,-0.055710286,-0.037996083,0.029946074,0.0016790014,0.017325995,0.01632178,-0.0056896326,0.03397322,0.014199271,0.015507627,-0.029431505,0.084380046,0.04540422,-0.07999878,-0.0009824211,-0.060881957,0.02174926,-0.009306231,0.037834838,0.049456414,-0.008192974,0.05628431,0.058850728,-0.030388942,-0.09953027,-0.018531928,0.04708033,-0.04245845,0.058073647,0.07794523,-0.03853279,-0.004432475,0.011974923,-0.097895116,0.018493932,-0.005291686,0.041483708,0.0022696105,-0.030991107,-0.044802286,-0.08320611,-0.014547604,0.0624929,-0.04361046,-0.03417413,0.0059725805,0.042047992,-0.07184617,-0.007315734,-0.11393312,-0.024597617,0.042936485,-0.034378957,0.023103436,-0.067947,-0.00033581528,-0.009679023,-0.02815138,0.06970459,-3.812854e-08,0.05620912,0.008181702,0.022813275,0.010922499,0.005150194,0.053269874,0.036274683,-0.005050661,0.05295638,0.0004901678,0.050913256,-0.0124513535,0.032391325,-0.03219455,0.043469045,0.15128672,-0.0070513343,-0.0023745538,-0.01810373,0.033679955,-0.018313045,0.016008435,-0.0038906208,0.05376095,0.024972307,-0.00044164882,0.07002929,0.031991698,-0.039077215,-0.062196027,-0.023555655,0.046481106,-0.01919227,-0.0417104,-0.074280664,0.018847132,-0.068002194,-0.0042043314,-0.03691954,0.097034596,0.07067827,0.075741954,-0.115960516,0.0024943256,0.02219585,0.07336266,-0.01319142,0.07872071,-0.07205824,-0.049785532,0.021709627,-0.022184078,0.03814041,0.007653574,-0.09846567,0.029775416,0.027427802,-0.10100373,-0.031669214,-0.033016015,0.05216746,0.023586385,0.15213077,-0.028367974 +4.2.3.147,Isolated from the plants Pinus banksiana (jack pine) and Pinus contorta (lodgepole pine).,384,1.0,0.0029438424,-0.0702542,-0.11241409,0.036375023,0.024766743,0.0051842835,0.0026731421,-0.038634982,0.089762546,0.025891554,0.08352425,0.03207752,-0.09614652,-0.0037228393,-0.07306068,0.034278505,-0.01796326,-0.01066383,0.02951418,0.053687878,0.07996254,0.032349475,-7.910877e-05,0.027476145,-0.0078069167,-0.063712284,-0.06014854,0.03447183,0.0034287947,-0.09444878,-0.032056976,0.033649866,0.057095848,0.015238195,0.004739973,0.05305963,0.010091479,-0.009496885,0.09900019,0.06381437,-0.068277195,0.019426506,0.08202857,-0.07230539,-0.03890789,0.02398506,-0.06314633,0.025852894,0.04837912,-0.036718644,0.027162129,-0.0115400795,-0.044696853,-0.0027090786,0.008899123,-0.058476403,0.04865025,-0.052949116,0.028001552,0.04573881,0.080045536,0.05902711,-0.0117712775,-0.0043677255,-0.047790326,0.033106714,-0.14603172,0.09258914,0.12446768,-0.066057265,0.007823963,-0.04961167,-0.021276439,-0.028844846,-0.03192518,0.035237227,-0.038618762,0.014384259,0.05294134,0.019093577,-0.06149438,-0.0024931931,-0.028216245,0.011954353,-0.05233365,0.021427115,0.011030877,0.12614241,-0.043035083,-0.06792678,-0.03736235,0.052879103,0.0014172007,-0.028421,-0.008697509,-0.0284918,0.05104457,-0.025555236,-0.049286455,-0.00026950584,0.067304544,-0.020248706,0.062096745,-0.18191028,-0.06741816,0.016989322,-0.0390671,-0.018634116,0.06507228,-0.030432574,-0.0460699,0.024745753,-0.020872248,0.03306062,0.02036741,-0.004599208,0.071265794,-0.04581478,0.03131005,0.0027796621,-0.033358693,0.0016812326,0.09819721,-0.038483556,-0.009871522,0.0629351,-0.06634233,5.765926e-34,0.08682983,0.003923166,-0.027906781,-0.030763425,0.049081475,-0.01493741,-0.0013950774,-0.07351993,-0.075512774,0.06799193,-0.09415912,-0.08111563,-0.001267884,-0.04823579,0.005096103,0.0269538,0.028206965,-0.0078596985,0.028446432,-0.035324045,-0.045447707,0.1132962,-0.042128157,0.00028573445,0.04409244,-0.049468774,0.0032853892,-0.068951234,0.052632887,-0.024282044,0.099073336,-0.054554924,-0.025171295,0.0008372974,0.06264948,-0.010066539,-0.028749796,-0.048515357,-0.055887666,0.031646796,0.1016952,-0.0012352675,0.08881067,0.022784008,0.03906385,-0.00799847,-0.05423176,0.014801025,0.077868916,-0.01819428,-0.011921027,0.041912362,-0.009816773,-0.02238175,-0.062921174,-0.080920324,-0.0078451075,0.06814614,0.07087527,0.058433596,-0.020853445,0.004176746,-0.06654602,-0.06065719,0.015341643,0.03697025,-0.118175074,0.06986363,-0.115569495,0.008709954,-0.040000413,-0.11573021,-0.05000248,-0.09235302,-0.026127318,0.0066393665,0.024547495,0.039137546,-0.020745166,0.018132886,-0.05714577,0.059991427,0.022064775,0.04047951,-0.05523243,0.0006978147,-0.0058594947,0.035755355,-0.008849822,0.057476725,-0.0052643022,0.051443506,-0.05733602,-0.06616313,0.06423032,-1.5627926e-33,0.0017751245,-0.012417621,-0.006060883,-0.058312904,-0.037385806,0.08920347,-0.059996914,-0.03509297,0.032914974,-0.051515784,-0.03073852,0.02231062,0.08838086,-0.0057405205,0.0075525064,-0.012155525,0.040169362,0.12695308,-0.051135004,-0.015661145,-0.06633562,0.07883618,0.008166789,-0.0977765,-0.0239667,0.00500645,0.0031301156,0.021439554,-0.018989882,-0.05631631,0.11391871,0.01555336,-0.056867693,-0.018732773,-0.11923165,-0.019173637,-0.039684113,-0.11700984,-0.00027602908,0.029746046,-0.039317936,0.00840788,0.054129135,0.06629489,0.07813868,-0.015523997,-0.03205274,-0.035281166,-0.07291851,0.1435818,0.015864275,-0.0263336,0.028921297,-0.033675805,0.031683672,-0.045254223,0.01761844,0.0540352,0.044448286,-0.052027877,0.02264432,-0.026507674,-0.01600741,-0.016104762,0.082377635,0.06909431,-0.043406703,0.03917122,-0.047103923,-0.016399605,0.0070701917,0.08973497,-0.009504429,0.06300557,0.052384175,0.05629618,-0.03223331,-0.047632996,0.008847009,-0.023073347,0.0061094696,-0.009230233,0.030641714,-0.020503836,0.03340812,-0.020534234,0.035682403,-0.033045195,0.037634686,-0.011482674,0.009272192,0.015428855,-0.046256576,-0.009792579,0.079688005,-2.1299757e-08,0.037789356,0.035091046,-0.05374441,-0.0358103,-0.03815085,-0.017417956,0.024540361,0.038898095,-0.014095164,0.02242342,-0.010061315,0.010343106,0.017292744,-0.03938819,0.041182186,-0.025454447,0.04406671,0.04675061,0.000583229,0.06000192,-0.044197544,0.0060110264,-0.015850306,0.11180106,-0.056078993,-0.07695823,0.10139749,-0.001282308,0.079682834,0.02157044,0.06678951,0.07990449,-0.024340972,-0.017099658,0.0069669574,0.036424436,-0.017771557,0.11469799,-0.035969328,0.041899778,0.011490451,-0.092690095,-0.056662384,-0.037829153,-0.08070229,-0.03774275,-0.009801147,0.060288917,-0.016246643,0.014285328,0.0076638767,0.030900054,0.064415075,-0.008624412,-0.030656852,-0.039335586,0.054094166,-0.055961017,0.060029835,-0.027701424,-0.051801864,-0.008596229,0.062244717,0.057078272 +5.1.3.30,"The enzyme is highly specific for D-psicose and shows very low activity with D-tagatose (cf. EC 5.1.3.31, D-tagatose 3-epimerase). The enzyme from the bacterium Clostridium scindens requires Mn2+ [1], whereas the enzymes from the bacteria Clostridium cellulolyticum [2,5], Clostridium sp. BNL1100 [3], and Clostridium bolteae [4] require Co2+ as optimum cofactor. The enzyme from Ruminococcus sp. [6] is not dependent on the presence of metal ions, but its activity is enhanced by Mn2+.",384,0.99999994,-0.010123176,-0.094692975,-0.05881859,0.01672557,0.11143967,-0.040851247,0.0025743225,0.022612158,0.017398715,0.02307335,-0.0026849972,-0.0070674536,-0.04108706,0.07581276,-0.018868692,0.0029295462,0.0118335085,-0.06344684,-0.0028845302,0.07181804,0.12253629,-0.030755587,0.041309502,-0.0020349186,0.059961867,0.054386646,0.03420792,-0.020174421,-0.041958228,-0.017532645,-0.021149402,-0.02886373,0.08211199,-0.0704506,0.07547067,0.03643169,0.04687121,0.04688516,0.034930125,0.008527867,-0.0024655163,0.04460175,0.077243514,-0.0026628033,-0.058484826,-0.057246756,0.03019938,-0.023768123,-0.018935552,0.08152818,-0.04474486,-0.055503335,0.06094901,0.0058705606,-0.0012630254,0.081952974,-0.04082194,-0.0138065815,-0.0026191568,-0.06464845,0.03571738,-0.025575174,0.04121548,0.040124983,0.02905477,-0.06391238,-0.009222588,-0.038898144,0.025876652,-0.06499996,0.006332529,-0.03767885,-0.03148653,-0.01823581,0.038791023,0.056968257,0.06067846,-0.12684265,0.045630373,-0.071094215,-0.014557103,0.02927791,0.06862875,0.023949245,0.0125969155,0.04713135,0.08279055,0.0016576418,0.013342236,-0.0007940309,0.062054507,0.002651214,-0.012595148,-0.04970804,-0.021950543,0.04697048,-0.013658916,0.06515008,-0.018449195,-0.00028965934,0.0034226626,0.061797675,-0.09125727,-0.12774143,-0.009988775,-0.0020466829,0.06289076,0.1063244,0.03290873,0.0025480564,0.07506776,0.04709529,0.021201432,0.059055176,0.016130589,0.008374965,0.14412898,-0.077091604,-0.09333328,0.04247791,0.060464073,-0.057758022,0.022898078,-0.017238298,-0.020235235,0.10377135,-0.041699912,3.7079357e-33,0.041864987,-0.028791571,0.018092105,-0.055387836,-0.009463119,0.032181866,-0.08050035,-0.06508252,-0.004857634,-0.007412296,-0.086693995,-0.094440326,0.06097863,0.030314034,-0.015985636,-0.015988892,0.010084118,-0.014510744,0.11323567,-0.011377764,0.040952653,0.058550045,-0.03576814,0.016786773,0.03150677,0.075562365,0.07444578,-0.0037269632,0.039755132,-0.013336399,0.059228867,-0.09399868,-0.06389384,0.010714634,0.10219015,0.047368873,-0.06079582,-0.009053434,-0.038002964,-0.026887063,-0.03393696,-0.007944062,-0.072068445,-0.0005067182,0.00030521018,-0.13194945,-0.07052765,0.07461727,-0.023375025,0.045093335,0.0181016,0.028948214,0.06928125,-0.0500287,-0.07146698,0.017540047,0.00089970924,-0.007145582,0.12210547,0.03025892,-0.07146723,0.038018797,-0.016433874,0.05465921,0.05668791,-0.044081617,-0.02115538,-0.0651666,0.0016441435,0.07724044,-0.0281313,-0.08398235,-0.026927542,0.0050511337,-0.0071687168,-0.030511476,-0.045763083,-0.033182558,0.08526369,0.012545476,-0.05124013,-0.047978707,0.029481454,0.0028451409,-0.084367305,-0.039772473,-0.15932935,-0.07324493,0.025011692,0.026290914,0.041432843,0.025442472,-0.07697576,-0.008440632,-0.009779887,-4.2749192e-33,0.047965467,0.008064902,0.10278904,-0.06191682,-0.09367882,0.04513516,-0.0046571144,-0.03135982,0.0493972,-0.06936504,0.09424512,0.0017405426,-0.07727353,-0.0049416586,0.042082228,0.099391535,-0.043283038,0.057228565,0.08709014,0.007063248,0.012183766,0.091443524,-0.019151082,0.04989446,0.07742972,0.028664669,-0.013829544,0.057597857,0.06400154,-0.037531737,0.040817004,0.022913815,-0.011224682,-0.064698935,-0.048616707,0.041820187,-0.027080918,-0.007496768,0.020297488,0.043960754,-0.058107972,0.011056248,0.04244183,0.030278182,-0.0154909985,-0.0156040415,-0.086008705,-0.023695415,0.037256192,0.007944682,-0.010110115,-0.025617938,-0.040005524,-0.051470384,0.0849587,-0.02109252,-0.00071641797,0.0010511467,-0.06282196,-0.056811612,-0.049193118,-0.01834029,0.033029996,0.010216846,0.043180354,0.012971561,-0.039044913,0.067149594,-0.012922264,-0.090822116,0.041722644,0.044978578,0.031375658,-0.0046493285,-0.06800014,-0.062297028,-0.010057641,0.04122546,0.08428516,0.0067734043,0.012353692,0.060399935,-0.026014287,-0.047671746,0.0043767905,-0.033283226,0.030436553,0.055698186,-0.030932363,0.03319302,-0.07091293,-0.07038109,0.01612549,0.043430604,0.061458033,-4.4187793e-08,-0.009670607,-0.077781714,0.04893243,-0.08379236,-0.016017744,0.03688556,-0.035392363,-0.038874436,0.02172093,-0.016468378,0.056408748,0.05619765,0.009506347,0.01656453,0.01528129,0.0024718416,-0.030710611,-0.02142841,-0.0508666,-0.0014522419,-0.049556952,-0.035746314,-0.13124254,0.062595986,0.024070106,-0.041016623,0.039306886,0.05069141,-0.047596548,0.0074017625,-0.030076252,0.030723676,-0.022908967,-0.013382304,-0.039543517,0.026260836,-0.05834559,-0.04629914,-0.051353578,0.023535984,-0.06446512,-0.040546484,-0.010666332,-0.030764902,-0.04669411,-0.11247496,-0.06318388,0.050411507,-0.042138718,-0.04029212,0.031449333,-0.06608898,-0.004573941,-0.0400079,-0.022133106,0.10290807,0.038245007,-0.07748956,-0.03966322,-0.05168396,0.054430682,-0.03145467,0.10760126,-0.063404925 +5.1.3.31,"The enzymes isolated from the bacteria Pseudomonas cichorii [2], Pseudomonas sp. ST-24 [1], Rhodobacter sphaeroides [3] and Mesorhizobium loti [4] catalyse the epimerization of various ketoses at the C-3 position, interconverting D-fructose and D-psicose, D-tagatose and D-sorbose, D-ribulose and D-xylulose, and L-ribulose and L-xylulose. The specificity depends on the species. The enzymes from Pseudomonas cichorii and Rhodobacter sphaeroides require Mn2+ [2,3].",384,1.0,-0.047495198,-0.07821108,-0.10048993,-0.04303855,0.07315294,0.04200004,-0.09169905,0.0054748035,-0.010010504,0.039514825,0.047068313,-0.09601625,0.020567592,0.0322717,-0.0638085,0.030311259,-0.06335197,-0.0054978686,-0.0036168091,0.06590274,0.104733095,0.02093954,-0.07953391,-0.008956866,0.074046776,0.0893693,0.098320894,-0.081011996,-0.08391071,-0.022131573,-0.055837013,-0.06407158,0.11355109,-0.102300644,0.16090614,0.08016978,-0.022590261,0.008744502,0.13571283,-2.2022738e-05,-0.014386115,0.0068425736,0.0868315,-0.10210397,-0.093550436,-0.019348128,0.0368898,0.0067393146,0.002825818,-0.049125046,-0.06389883,-0.056918453,0.023302635,0.07107098,0.06504857,0.06711031,-0.039180577,0.022009423,-0.04038432,-0.004093937,-0.0052407766,-0.05234565,0.010319195,0.0111348,-0.028824884,-0.054041043,-0.0115232505,-0.056397405,0.028797552,-0.020016927,-0.058498673,0.009451547,-0.017231256,0.012621826,0.02873995,0.03191258,0.06294642,-0.028577834,0.012666298,-0.034085233,-0.045494657,-0.014474391,0.059079558,-0.016466502,0.028285453,-0.039364,0.032389525,0.08198278,0.07644057,0.034991097,0.051211573,0.030841047,-0.036565587,-0.07335897,-0.061228294,0.056692515,-0.013594683,0.051267345,0.050137997,-0.04736716,0.023466412,0.0147272535,0.008729884,-0.12179292,-0.004864133,-0.011437727,-0.013219803,0.13261358,0.016405247,0.038943034,0.06372453,-0.0074163727,-0.0032350703,-0.015917452,0.008979558,0.041249372,0.09939872,-0.11019963,-0.056580964,-0.01739671,-0.013480817,-0.013658565,0.028476182,0.027465649,-0.019890588,0.06787852,-0.100709975,2.5402196e-33,0.02087286,0.025826028,-0.032040555,-0.09076757,-0.01752034,0.009325407,-0.06979455,-0.0045908587,0.032145344,-0.06062633,-0.059185598,-0.02145925,0.035831265,-0.04318181,-0.008703052,-0.0047843647,0.007968955,-0.006662871,0.084730804,0.05636554,0.015628424,0.011589129,-0.067768306,0.0023079554,-0.0015989705,0.06260025,0.107255936,-0.08937097,0.0054352754,-0.015223374,0.03843991,-0.066587344,-0.08043874,-0.0034725834,0.12054881,0.018719394,-0.045657538,0.0035273682,-0.015293696,0.055935163,0.006325523,0.014226997,-0.044643983,-0.023944851,0.033924688,-0.027868135,-0.04935963,0.0891056,0.0076884665,0.05275422,0.024248667,0.018844912,0.0729081,0.021346133,-0.079041794,0.00963093,0.0143595375,0.024334371,0.11031821,-0.016923133,-0.028608633,0.07315804,0.0094969785,0.031920332,-0.017581157,-0.045768693,-0.050290763,-0.040898446,0.03558722,0.08921882,-0.10221324,-0.07040594,0.037598617,0.013515331,0.0073479097,-0.078391336,-0.095355056,-0.024615953,0.032001264,0.033056706,0.010830354,-0.021465814,0.010720409,-0.06484879,-0.053404808,-0.028668212,-0.106094584,-0.047782816,-0.034367952,-0.0058377758,0.05497367,-0.05996981,-0.064938925,0.07584269,-0.01706992,-4.2802427e-33,0.1337051,-0.083196886,0.093736045,-0.072864495,-0.07459515,0.053086124,-0.013156266,-0.026818365,0.01922289,-0.065719455,0.05268623,0.017443474,0.0151942205,0.038403973,0.015382557,0.018545827,0.028581528,0.08089514,0.06133307,-0.04587404,0.032868102,0.026889056,-0.079320125,0.05299688,0.039503973,0.033119198,-0.015082113,0.07869419,0.020241488,0.039524104,-0.006242836,-0.0068090293,-0.045566615,-0.08685158,-0.04923945,0.019261416,-0.090193205,-0.017552482,0.10075022,0.050915275,0.027312355,0.01451273,-0.0018701061,0.06066838,-0.06831338,0.015269537,-0.06319159,-0.006921956,-0.0012886545,-0.065858856,-0.06627707,0.028218536,-0.051020917,-0.060414135,-0.01610235,0.012411295,-0.016797658,0.033847764,0.005046957,-0.066025384,-0.07955802,-0.08432982,0.04650697,0.0014367587,0.016305119,0.08530873,0.04230498,0.029809687,-0.014775841,-0.015568803,-0.007103514,-0.019999456,-0.00799918,0.045496326,-0.020668881,-0.055510074,-0.035779126,0.019071655,0.057673,0.006778582,0.06401454,0.005613671,0.0005876063,-0.021838874,0.03983114,-0.028611245,0.06477312,0.04884873,-0.07017623,-0.00450839,0.0160291,-0.000112193615,0.040350467,0.034979273,0.07795309,-4.5054694e-08,0.03303464,-0.0858165,0.039891407,-0.010754576,0.0021236958,0.040447276,-0.02363275,-0.020570707,0.052536245,-0.04280427,0.00028892062,0.012920168,-0.0251871,0.010829803,0.053134456,0.009126167,-0.078805804,-0.025732858,-0.030268073,0.020889485,-0.055959355,-0.037204817,-0.12626082,0.042274464,0.008541478,0.029052084,0.038386974,0.008978005,-0.02995327,0.045556508,-0.06088375,0.029623576,0.02715728,0.0018780506,-0.030589374,0.012718327,-0.036342345,-0.038022615,-0.09105366,-0.03361509,-0.01725113,-0.04120574,-0.04816624,-0.011495403,-0.004472864,-0.010858954,-0.02082638,0.07834514,0.008281482,-0.027030015,0.03155196,-0.026377972,-0.00359306,-0.026972286,-0.01364093,0.070822574,0.012131842,-0.06422642,-0.08500778,0.03473795,0.025095193,0.04057336,0.08249602,-0.019958638 +5.1.3.32,The enzyme is specific for L-rhamnopyranose.,384,0.99999994,-0.0051074955,-0.08286943,-0.09463466,0.004732705,0.123318136,0.062216774,-0.097555555,0.099757776,-0.02206362,-0.025152517,0.0066804267,0.055884168,-0.07195153,0.07895985,-0.06935638,0.117594965,-0.032339107,-0.0010503875,0.016031576,-0.013284224,0.058259457,-0.0047201617,0.0036570968,0.0042009423,0.10096965,-0.027893268,0.04756277,0.015765747,-0.023361549,-0.006667104,0.00092444237,-0.06687832,0.06063333,-0.035779387,0.00076400983,0.091517285,-0.057157643,-0.039249092,0.08716235,0.09210826,0.028963257,-0.045706157,-0.007109651,-0.014142317,-0.040858366,-0.03240073,-0.084503636,0.047382805,0.015714075,0.06018857,-0.037715055,-0.08394881,-0.06302629,0.041595634,-0.076432824,-0.054674234,-0.11237533,0.03363915,-0.012529103,0.043165952,0.032547474,0.032169353,6.13713e-05,0.036714252,0.025409203,-0.029572152,0.0009995188,-0.035739325,0.05461651,0.028822586,0.031069124,-0.07333125,0.012422799,-0.010684427,0.03293581,-0.050791837,0.02200582,-0.014445301,-0.023727616,0.013673089,0.006211167,0.056136,-0.0011250075,0.017296644,0.03537715,0.020224568,0.007237327,0.08059558,0.002045387,-0.03536292,0.03753584,-0.06945645,-0.101145975,-0.02351639,-0.056955595,-0.043519907,-0.025407217,0.022945566,-0.030990325,-0.048918776,-0.03133457,-0.013613276,-0.0036046046,-0.065710396,-0.06458228,0.014904654,-0.003157129,0.013472236,0.005612025,-0.06287026,0.009988603,0.035382625,0.045099575,0.04348768,-0.058042582,0.073516645,-0.030995319,-0.06487695,-0.079720296,0.092817225,0.05548765,-0.027865062,0.05165209,0.007847183,-0.022639086,0.049527835,-0.10223779,-1.6497971e-33,0.0463438,0.026228387,-0.0057768817,-0.031029101,0.028714126,0.059307907,-0.063567296,0.040249113,-0.0410396,0.011687955,0.006815173,-0.019103788,0.023735473,0.008148901,-0.07704916,0.054659262,0.026241198,-0.0117731495,0.041490745,-0.010007133,0.022575058,0.033035297,-0.096912555,0.024383614,-0.032633897,0.05176918,0.020478254,0.0348924,0.06616101,-0.006785483,-0.01899829,-0.0566433,-0.03834364,0.02867315,-0.0155187305,0.039107334,-0.055790283,-0.09131849,0.0102885775,-0.012267985,0.039083842,0.049018722,0.0035025356,-0.004228778,0.040540718,-0.07867095,-0.07869829,0.015473892,0.042646278,0.07060884,0.056269478,-0.019974634,0.08085515,-0.0056516975,-0.006946723,-0.03070107,-0.1122078,0.062978685,0.033447344,-0.006387473,0.02799444,0.006722217,-0.0034434288,-0.012997828,-0.0021401083,-0.022992345,0.014152594,-0.066059284,-0.017024357,0.056414895,-0.05760534,-0.05189329,0.1016557,0.05463352,0.04714723,-0.077703305,-0.005135931,0.008243561,0.06485267,-0.0030516896,-0.04133777,-0.029518077,0.022492005,0.011233554,-0.058653615,-0.064791605,0.009110167,-0.034699786,-0.025377864,0.008377019,0.0076237433,-0.11269167,-0.08550337,0.036939025,-0.0025489263,1.1404169e-34,0.061273474,-0.11157345,0.069024265,-0.04367204,-0.009261565,0.04238924,0.07136352,-0.0053009707,0.03371622,-0.0042623654,0.08514514,-0.03865243,-0.03314302,0.00041544766,0.06972527,0.036775168,-0.023138694,-0.013010312,-0.008339999,0.012959898,-0.06463637,0.076933034,0.047515996,0.04754282,0.055561297,0.015044845,0.00119896,0.085197546,0.005147659,0.03341159,-0.049292892,0.00024432794,-0.0806255,-0.07904517,-0.027020495,0.10531485,-0.055966806,0.003815791,0.012264964,0.021203782,0.06142818,0.023205055,-0.01287332,0.05289686,-0.014657149,0.049876977,-0.03196873,0.007592261,0.041108593,-0.09986375,-0.032466076,0.04713176,-0.030610517,0.028990185,0.03688161,0.0591376,-0.091926575,0.019829625,-0.050602674,-0.029704219,-0.024425816,-0.053746194,-0.029588109,0.028378615,0.027321763,0.07144804,0.0014988077,0.05532328,0.052249365,0.018354597,0.10122837,0.052607283,0.06931325,0.08135852,-0.073633656,-0.09204164,-0.064674325,-0.11444946,-0.02227727,-0.051779892,0.03572286,-0.02895046,-0.005999261,-0.00061205006,-0.0047243857,-0.027223565,-0.0052190935,0.10378207,0.03380025,-0.021210376,0.04373497,-0.05588188,-0.09557455,0.014948103,0.10427741,-1.9230887e-08,0.08387229,-0.084240794,0.096216306,-0.09396608,0.0065865116,0.007609139,-0.012684045,-0.0024520298,-0.075001344,0.08277062,0.00060916546,0.04909981,-0.020647606,-0.027371127,0.02049161,-0.020531356,-0.014013897,0.09825784,-0.016905535,0.03628699,-0.063027844,0.0060775355,-0.048217993,-0.016598308,0.027319144,-0.015434461,0.028516937,0.055931672,-0.020553404,-0.018806567,0.047403034,0.010246504,0.058848064,0.05992905,-0.121620014,0.029947579,-0.04466085,0.032400068,-0.047982883,-0.03593707,0.035428904,0.0025584907,-0.029708453,0.030691793,-0.028024731,-0.049885973,0.026730562,-0.044532865,0.048466854,-0.04915814,0.016692253,-0.05004246,-0.033267517,-0.07591516,-0.04695974,-0.03532949,-0.027246594,-0.0044319527,-0.016140906,-0.11732417,-0.032209385,0.043062974,0.22318706,-0.038083926 +5.4.99.62,The enzyme also catalyses the conversion between beta-allopyranose and beta-allofuranose. ,384,0.99999994,0.033012502,-0.03574222,-0.09319646,-0.0045823893,0.048895147,0.059408545,-0.028333504,0.0070317546,-0.02998059,0.036597867,0.011350695,-0.01696313,-0.09198154,0.020378606,-0.044300653,0.057448145,-0.05349151,-0.028234337,0.021571128,-0.020259086,0.07602526,-0.060804915,-0.045632873,0.0358711,0.07759698,0.025723523,-0.031347856,-0.058272656,-0.035029475,-0.080789626,-0.062465973,-0.041395273,0.059784967,-0.005746619,0.034186255,0.006527752,-0.065314874,-0.027502334,0.0022018682,0.008484438,0.010794267,-0.020268505,-0.052838765,0.0015582202,-0.028717754,0.0046189656,0.0026653914,0.06146738,0.076497264,-0.01051425,-0.04919086,-0.111315735,-0.09011664,0.0095670195,0.03858241,0.07563778,-0.045171,0.0013331848,-0.015882168,0.038372807,-0.05762397,0.040649932,-0.049294885,0.070066854,0.055484995,-0.040967256,0.013190588,-0.034970548,-0.04891075,-0.032119364,-0.06195128,-0.033343423,-0.04536744,0.019284392,0.07542588,-0.024060303,-0.05274948,0.014726137,0.016972259,0.045645304,0.03423058,0.04199428,-0.00091155164,-0.01827496,0.02445432,0.09774131,-0.029334491,0.07149015,0.0839884,0.04680758,0.016887965,-0.036066357,-0.020212872,-0.015576357,-0.021415927,0.053930562,0.05907618,0.0057334253,0.10144584,-0.039082028,-0.015246362,-0.048880864,-0.0010458806,-0.104176275,-0.054163784,0.098768696,0.03350629,0.035648424,0.032882407,0.014042551,-0.03303401,0.031286605,0.08875852,0.073120296,-0.0821348,0.036154624,0.00015954333,-0.071115226,-0.05742383,0.0410082,0.03104288,-0.034557447,0.02954353,0.124559164,-0.0730326,0.10348575,-0.08874018,-2.3057322e-35,0.027676953,0.0626257,0.035975017,-0.06387111,-0.010982101,-0.0013454215,-0.0657654,-0.0070472513,-0.029388666,0.06522327,-0.07448998,-0.05107781,0.016199185,0.054671958,0.022407373,0.027385073,0.043340996,0.07191215,0.066169865,0.04612996,-0.040417146,0.05893579,-0.10493355,-0.015986314,0.021125408,0.074102886,-0.019230781,0.082972564,0.03522309,-0.0011759877,-0.004166559,-0.05674288,-0.0889323,0.037286505,0.048102498,0.00015529664,-0.020207915,-0.064334415,-0.0055622766,0.031313345,0.029530004,-0.008947669,-0.04294637,0.025457613,0.029297655,-0.035559352,-0.045690455,0.016117968,0.04268796,0.04165561,-0.013588132,-0.039442625,0.034246977,0.0027307374,-0.054645568,0.07099126,-0.009034069,-0.049474306,0.021335842,0.04642601,-0.06539464,0.010575108,-0.012066721,-0.06097179,-0.030264875,-0.033019833,-0.049321346,-0.052506927,-0.042794198,-0.0026214789,-0.048385147,-0.02921169,-0.00394861,0.00748835,0.03894349,-0.05302098,-0.018066444,0.025420954,0.06274953,-0.05686868,-0.025427798,0.043466143,-0.0066931406,-0.054120786,0.0054167914,0.019390915,7.221228e-07,-0.04811675,0.0034995389,0.06974617,0.03768351,-0.06074336,-0.07841468,-0.00033956033,0.021251328,-1.6391688e-33,0.0978633,-0.11496192,0.0020550634,-0.073341556,-0.03127118,0.057316035,0.002480034,-0.102475375,0.04430358,0.010696018,0.02011027,0.00034422008,-0.012251427,-0.10911232,0.0004435428,-0.0117584625,0.05834313,0.0556676,-0.03248092,-0.013078317,0.00074929494,0.080877036,0.037400525,-0.001641541,0.001847988,-0.058828127,0.04102444,0.13741203,0.10886689,0.09390486,-0.0061250255,-0.074705355,-0.041280434,-0.039081953,-0.020476626,0.039569706,-0.019212147,0.07456737,0.07009657,-0.0036461349,-0.012782693,-0.005516731,-0.0039371415,0.018640505,0.04284659,0.14576705,-0.06573846,-0.020103788,0.0071400045,-0.07539335,0.08719513,-0.0021374195,0.025503566,0.033346567,0.0016160328,0.028502496,0.032566547,-0.025363034,-0.011113548,-0.11791823,-0.011715224,-0.056874517,0.0072441637,-0.03787683,0.03225259,0.06574417,-0.035942852,0.015534454,-0.007847642,0.007870342,0.03565935,-0.058883607,-0.06921975,0.09567971,-0.01328717,-0.005557889,-0.079764165,-0.08512088,0.05726522,-0.023993619,-0.053799063,0.062685125,0.010361136,-0.072939605,-0.022463473,-0.08493254,0.08631232,0.105857566,-0.011140397,0.051360022,-0.030284183,0.018265888,-0.019244436,0.034927152,0.12668097,-2.3721949e-08,0.019243283,-0.0689556,0.027578149,-0.036730785,-0.022414701,-0.02390356,0.06020452,0.018060673,0.056657966,-0.058076058,-0.063518055,0.10054605,0.060234606,0.05849445,0.07043367,-0.0004524519,0.0073495233,0.005250697,-0.022198163,0.010010637,-0.08318391,0.022264067,-0.057028133,-0.016943073,0.029406816,-0.07282809,0.025101157,0.058636524,-0.009323616,0.028900744,-0.01246149,0.017785234,-0.032000694,-0.057297386,-0.036791578,0.013512889,-0.020334017,-0.011541127,0.09626016,-0.0025752187,0.01868221,-0.08375676,-0.017088942,0.00494473,-0.064969026,0.0022017004,0.038826384,0.004533229,0.021712696,0.022632908,0.114209086,-0.03185057,-0.07542562,-0.10852224,-0.08535531,-0.043249514,0.02022065,-0.049896054,0.017010273,-0.03859511,0.041396488,-0.007487192,0.17575829,-0.049577363 +6.1.1.28,"The enzyme attaches two different amino acids, proline and cysteine, to their cognate tRNAs. It has been characterized from the archaea Methanocaldococcus jannaschii and Methanococcus maripaludis, the protozoan parasite Giardia intestinalis, and the thermophilic bacterium Thermus thermophilus.",384,1.0,-0.095224425,-0.074143134,-0.1396798,-0.07273185,0.015134202,-0.0053105364,-0.048201226,0.07242362,0.034109514,-0.00032279853,0.03488536,-0.10411945,-0.02403535,0.057627197,-0.10989827,0.018110843,-0.054921284,-0.065441884,0.036645435,-0.04115169,0.03274748,0.06612774,-0.06205492,0.017812502,0.010843767,-0.023392795,0.093477905,0.053680375,-0.057461005,0.04109378,-0.0719025,-0.08314629,0.09621098,0.0029461072,0.07207945,0.09070793,-0.056781664,-0.035280943,0.054085,0.025412908,0.041904118,0.053952258,0.052186836,-0.028065458,-0.021614458,-0.014503871,-0.0077960547,0.03527737,0.048531048,-0.017285703,-0.047676582,-0.05054951,-0.026310725,0.077233344,-0.029294183,0.10925123,-0.0496019,-0.050299957,-0.04991247,-0.022308873,-0.0037783545,0.036401577,0.010289353,-3.4976925e-05,0.03892892,-0.051053658,0.027371462,0.008772662,0.018493652,-0.030919926,-0.07461086,-0.007227508,-0.048707064,0.055994514,-0.007609854,0.033049624,-0.009747227,-0.06034185,-0.023503494,-0.047843315,0.01264066,-0.0042495932,0.0074859536,-0.00064561627,0.03389205,0.036804445,0.05302494,0.041972578,0.07925806,0.0005412999,0.061144337,0.014290911,-0.009611947,-0.03010363,-0.120512225,-0.028021285,0.03132751,0.024950163,0.042807724,-0.041570436,-0.022345174,-0.02589686,-0.0014672226,-0.076255195,-0.05631899,0.0018719954,0.021663181,0.06431385,0.0055121877,0.006324237,0.02525064,-0.014071138,0.070231706,-0.028392388,0.028312353,0.056292284,-0.019232841,-0.008524443,0.0050353515,0.04603652,-0.047560852,0.022469882,0.06204911,0.08382738,-0.048711278,0.08046777,-0.07855426,5.4785523e-33,0.009404399,-0.0025363616,0.038838662,-0.013469395,0.059710216,-0.02713723,-0.060704954,0.009903875,-0.02895243,-0.06940408,-0.06792325,-0.011766904,0.03427303,-0.029597737,-0.020867432,0.06395001,-0.03665807,-0.024500465,0.009777583,0.1035327,-0.03654097,0.090887524,0.035842717,-0.0069097956,0.10881041,0.02124108,0.018279463,0.015624627,0.022472806,-0.008218621,-0.00943984,-0.13971846,-0.1105021,0.011992715,0.06609729,0.024819192,-0.003929115,-0.050505947,-0.078987144,0.0205605,0.01245032,-0.019129604,0.03984355,0.00832197,0.011302313,-0.03635929,-0.06633498,0.10601813,-0.009902908,-0.0072523085,0.056707613,-0.029592322,0.041736063,-0.037346322,-0.083944745,-0.006023797,-0.043938234,0.021727027,0.096759036,0.07529294,-0.021550305,0.046443064,-0.05125627,0.07687881,-0.0016790925,0.02888216,-0.07428108,-0.069444455,-0.0014399855,0.11725643,-0.12187987,-0.03435141,0.00824688,0.05916076,-0.016472504,-0.06814528,-0.05611457,-0.093502365,0.024423502,0.00036315274,-0.038299456,-0.02339432,0.06366468,0.0019739112,-0.082163915,-0.025707567,0.0040827026,-0.008602792,-0.014237266,0.07301879,0.049987778,-0.043982733,-0.03729936,0.06581779,0.0042378674,-6.235072e-33,0.062229425,-0.09120649,-0.00820098,-0.05979503,-0.09081896,0.1110052,-0.010971576,-0.06328931,0.0099217445,-0.06256033,0.09459656,0.011889556,0.0068571283,-0.016181601,0.08188237,-0.0055367183,0.043534435,0.055095207,0.014568132,-0.058041684,-0.0089372285,0.019080132,0.013637555,-0.097171046,-0.036148824,-0.012645474,0.030620847,0.108500615,-0.04245012,0.048343062,0.013618965,0.045915607,-0.052204426,-0.049089603,-0.068665266,0.08742341,-0.03002623,-0.05468978,0.12519398,-0.005370565,-0.013157892,0.011529416,0.0034134989,0.08197895,-0.05183905,0.06368368,-0.038838755,0.016030775,-0.0026920524,-0.0020312327,0.04614436,-0.025247782,-0.0047254907,-0.036472525,-0.014652181,0.01979724,-0.051305324,-0.009682449,0.02128206,-0.011765376,0.010906133,-0.0817383,0.0023387263,0.01041946,0.042323936,0.027718209,-0.030912038,0.0036931802,0.02641797,0.012269278,0.07173322,0.0029296696,-0.039314296,0.04849139,-0.029265627,-0.01580199,-0.03625519,0.04083956,0.0479841,-0.021718554,-0.010379011,-0.004241593,0.077220164,0.0015141563,0.015029837,-0.04119299,0.03726674,0.09316407,0.012123685,0.06606352,0.04273498,0.0050314306,-0.018529875,0.031983268,0.02340835,-3.8698257e-08,0.082061596,-0.071641855,0.068325356,-0.06216562,-0.027765494,0.04343678,0.030378537,-0.027202645,0.05670551,-0.024414046,-0.013648346,0.09409987,-0.030466253,0.077751644,-0.026597466,0.08235997,-0.11027482,0.0039800107,-0.042728268,0.01786163,-0.053029034,-0.0028661392,-0.1551646,-0.0059123,-0.035828248,-0.021416666,0.022098573,0.098121144,-0.061825633,-0.011617879,-0.049816784,-0.022388238,-0.010974131,-0.06884897,-0.05380261,0.019442037,-0.02257644,-0.005339176,-0.047901116,-0.010343978,0.0858504,0.0010436979,-0.06291288,-0.012374615,0.008973856,-0.026222177,-0.030064328,0.045728188,0.01550713,0.054636285,0.021838685,-0.00828563,0.06431252,-0.013008306,-0.09099764,-0.09316376,0.015607941,-0.074393995,-0.064320154,0.009267677,0.0050099096,0.0029749041,0.15708728,0.0034364338 +6.2.1.44,"The enzyme is part of a dimethylsulfoniopropanoate demethylation pathway in the marine bacteria Ruegeria pomeroyi and Pelagibacter ubique. It also occurs in some nonmarine bacteria capable of metabolizing dimethylsulfoniopropionate (e.g. Burkholderia thailandensis, Pseudomonas aeruginosa, and Silicibacter lacuscaerulensis). It requires Mg2+ [2].",384,1.0,-0.0875273,-0.01963206,-0.063753515,-0.01812395,0.011817039,-0.0257833,-0.05621888,0.019461168,0.0046383347,-0.059863083,0.011714358,-0.05307764,-0.012634536,0.0022886689,0.011493827,0.082840554,-0.07463306,0.051953513,-0.011780382,0.049338464,0.11345297,0.08820437,-0.048942126,0.001606227,-0.033529505,0.035444953,0.10205507,0.047658555,-0.007198101,-0.02301184,-0.017861675,0.012153293,0.078053355,-0.1020299,0.10927177,0.07495054,-0.0053238035,-0.01934973,0.0141575765,-0.025967086,0.07370454,-0.009142698,0.0260245,-0.010842467,-0.02239868,-0.08067489,0.070165776,0.015831735,0.010617222,0.0005453521,-0.06543732,0.0007224232,-0.04542687,0.042976875,0.061371252,-0.017077534,-0.029046798,-0.02166677,-0.030618187,-0.05895236,0.01613996,0.03279043,0.0067404257,-0.07261102,-0.06974166,-0.030794716,0.06885648,-0.06503217,0.060267407,-0.06539688,-0.05395035,-0.026007472,-0.023991901,0.046245333,-0.028859546,0.016635742,0.0053110956,-0.056971855,0.07914297,-0.028184004,0.0076881815,-0.019910203,0.027815556,0.08336984,-0.0027042276,-0.05578659,0.07366873,0.022007037,0.10662999,0.052549906,0.05466118,-0.016455038,-0.05930863,-0.071039796,-0.10225372,0.02598366,-0.07932905,0.03593098,0.011966185,-0.0012475876,-0.0006939237,0.012140611,-0.026427304,-0.100765415,-0.042779792,0.0012483437,0.061143793,0.1249552,0.05190562,-0.016488872,0.0343624,0.04014066,0.039936554,0.046901025,-0.018638266,0.06199604,0.024967046,-0.1515518,-0.02854024,0.003453286,-0.011906318,-0.028115252,0.025849115,0.056106508,-0.019718578,-0.0016700799,-0.10296821,6.129164e-33,0.043954156,0.044749267,0.043262262,-0.080932416,-0.0030689116,-0.022036174,-0.10829185,-0.027595524,-0.0090098865,-0.047086094,-0.07581251,-0.07106471,-0.026387447,0.07924875,-0.016797611,-0.01828057,-0.0073201004,0.069902465,0.095034145,-0.051690344,0.034878906,0.06848101,-0.029757716,-0.07477444,0.015672445,0.099889964,0.055307653,-0.061777934,0.05945784,0.02918418,0.07691077,-0.13106675,-0.07212553,-0.036217194,0.11918408,0.025380677,-0.042851508,0.02129304,-0.038671877,0.063885435,-0.08140176,0.028387139,-0.038937464,0.006976046,-0.0027067687,-0.054926574,-0.021657838,0.09893996,0.047909997,0.027774477,0.03994591,-0.040855385,0.036580462,0.020802451,-0.08082052,0.03650359,0.014501687,-0.0013988222,0.07927392,-0.036242373,0.026386714,0.01453692,-0.01011872,0.03514993,0.079103425,-0.00038281808,-0.0028432934,-0.02123146,0.014225542,0.031214992,-0.06101398,-0.07068625,0.04079938,0.043250766,-0.036167298,-0.057914343,0.004675422,-0.014922255,0.0679512,0.041349556,-0.07261547,-0.0601016,-0.00051357195,-0.08664221,-0.08182613,0.025378585,-0.045193456,-0.020891748,-0.011419067,0.0103485435,0.007574797,-0.05158287,-0.05950973,0.02108535,-0.013630069,-7.441529e-33,0.04494331,-0.070239484,0.09889964,-0.07749102,-0.050352585,-0.005007879,0.033830877,0.06661871,-0.00032736218,-0.024583822,0.03562049,0.008552739,0.0065037864,-0.022627123,0.048289124,0.045406234,0.07979888,0.0514523,-0.04637663,-0.044397466,0.036439,0.0111568915,-0.034784343,0.059421755,-0.0048822216,0.021261603,0.02801147,0.046354387,0.027679533,0.06301429,0.035092644,0.06957086,-0.036287036,-0.056161717,-0.10527772,0.031488113,-0.028958473,0.012088627,0.021391636,0.033885334,0.023428194,-0.044133704,0.005725507,0.086640276,-0.032934878,-0.008007997,-0.04273764,0.025383363,0.040264655,-0.10383956,-0.013917715,0.034113813,0.01130888,0.0081984745,0.0054903543,0.018783698,-0.021513492,-0.00739597,-0.0050953864,-0.061993677,-0.02970249,-0.068733424,0.003606486,-0.032741472,0.014160285,0.13134281,0.051052902,0.0012272684,0.0130962245,-0.023462756,0.022400074,0.024438908,-0.03853044,-0.007041504,-0.05157234,-0.0017483166,-0.09919421,-0.029868053,0.0060889977,0.014886537,0.079821125,-0.029210886,-0.019919593,-0.055643655,-0.07054144,-0.12083316,0.057724837,0.15368436,0.010207253,-0.03339804,-0.052912295,-0.02857901,-0.080043,0.031283773,-0.034494955,-4.5738304e-08,-0.060585883,-0.098950386,0.046086736,0.038743384,-0.07758781,0.04146477,-0.021727175,0.040611707,0.0427231,-0.009751337,0.050717436,0.052552532,-0.058670502,-0.015440752,0.052807663,-0.00055663777,-0.008036465,0.022408886,-0.027335161,-0.032407675,-0.056738857,-0.006196,-0.0910488,0.0048438297,0.021146437,-0.01861256,0.035741467,0.03657675,0.0018573164,-0.041660614,0.03652737,0.04640943,-0.07637224,0.009514056,-0.048115667,0.037337814,-0.030174188,-0.060640264,-0.044983562,-0.024484638,0.03472648,0.031863045,-0.03147551,0.012712725,0.010430876,0.042393964,-0.014226717,0.09172754,-0.04751208,-0.014990325,0.06488297,-0.019667948,-0.025083125,-0.021495886,-0.108455054,0.058964625,-0.01725601,-0.07848514,-0.076836586,0.010814631,0.07795025,-0.012507281,0.12594958,-0.035453588 +6.3.2.43,The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW. This reaction is part of the lysine biosynthesis pathway in these organisms.,384,0.99999994,-0.051453862,-0.082233176,-0.11126691,-0.010187702,0.09218729,0.10338968,-0.079234235,0.013217135,0.028458914,0.019767487,0.019337418,-0.07952338,0.008669935,0.005669397,-0.032573245,0.06961541,-0.10350855,-0.039676294,-0.027788615,-0.09188726,0.09358614,0.060145207,-0.095010914,-0.022504516,0.024211822,-0.02708211,0.009610545,-0.03969796,-0.032605346,0.038782638,-0.031882253,-0.057165213,0.052892588,-0.02415267,0.011967526,0.09803333,-0.078803115,-0.08199203,0.08823689,-0.006201421,-0.0007519986,-0.0027130132,0.009499219,-0.047107194,-0.08674577,0.042754043,0.040063385,-0.011510907,0.027579585,-0.013162119,-0.027081633,-0.023592029,-0.017306399,0.022326404,-0.07399504,0.03230396,-0.050139856,0.0028843726,-0.001153182,-0.04008289,-0.03229499,0.08640454,0.0027760742,0.05417319,-0.024099685,-0.07086101,0.047317162,-0.010973234,0.00785321,-0.025914185,-0.03876425,-0.0690571,-0.008855091,0.035167456,0.052339576,0.045318365,0.02015209,-0.036272347,0.036441248,-0.087463744,0.039323103,-0.07165468,-0.014472706,0.09546345,-0.027659046,-0.03240195,0.052119583,0.036533047,0.10037669,0.0005190628,0.037789755,-0.0723871,0.008935464,-0.026856475,-0.070472725,-0.010508191,0.029507454,0.0029598249,-0.013819488,-0.057583567,-0.022766791,-0.019312365,-0.042840105,-0.04782702,-0.040008362,-0.03642072,-0.011426682,0.022209883,0.04188141,-0.025011193,0.046380427,-0.00199606,0.06260472,0.015203767,0.0030750385,0.035463464,0.023359355,-0.035832845,-0.060202986,-0.018071543,-0.013681481,0.04062487,0.07547859,0.072833486,-0.11470538,0.028100314,-0.09754458,5.4479274e-33,0.091924354,0.025437051,0.008446794,-0.062578306,0.010026609,-0.06460345,-0.07411534,-0.011864503,0.03992508,0.012726335,-0.052799236,-0.07095449,0.035788313,-0.015471195,-0.031094579,0.046894502,-0.011960961,-0.037961487,-0.0027432323,0.099231206,-0.111446485,0.06619558,0.06491582,0.037887935,0.07210427,0.03198763,0.0787917,-0.06012095,0.022765286,0.05130293,-0.04309528,-0.16386685,-0.115551956,0.0075349533,0.053106774,-0.006760919,-0.04596478,-0.044905722,0.012697489,-0.05224465,0.029677555,0.04478266,-0.0015055425,0.0036511621,0.028394924,0.034484874,-0.042895097,0.097647816,-0.040115636,0.05129341,0.004894304,-0.083052695,0.07297625,-0.07607855,-0.07010661,-0.009636285,-0.019734517,0.042940967,0.036194526,0.064425096,-0.018263012,0.06942486,0.015357399,0.038689736,0.001128153,-0.011232064,-0.033288393,-0.09158139,-0.025504416,0.026584681,-0.11311553,-0.04651747,0.06513376,0.040496774,0.01764769,-0.02911062,-0.024264582,-0.05672818,-0.007207093,-2.216676e-05,0.0021584178,-0.030289318,0.027309978,-0.019523848,-0.0028605226,-0.072864644,-0.0009885735,-0.0061593116,-0.049929976,0.026244687,-0.0051783063,-0.07027444,0.03445519,0.08770974,-0.011696523,-7.1356114e-33,0.054757386,-0.10173652,0.005289849,-0.08083869,-0.08123331,0.033042174,0.028430542,-0.026369708,-0.030565633,-0.0029800318,0.06760183,0.027133431,0.024467029,-0.066476144,0.06360266,-0.01723321,0.09441207,0.0970508,-0.01172392,-0.049636748,0.0084678745,0.017878223,0.0037652424,-0.03632512,-0.014496157,0.006202049,-0.049211584,0.097244,0.039067175,0.012455839,0.041964497,0.017820988,-0.058218326,-0.09135267,-0.03107032,0.037058856,0.016337892,0.02179344,0.11207822,-0.0021262772,0.04716058,-0.011813087,0.013562147,0.06162013,0.0018374312,-0.02931088,-0.05950766,-0.06421528,0.026512276,0.0056943246,0.033498753,-0.08007634,0.02038984,-0.033322383,0.010325936,0.030361356,-0.043080308,0.03222999,-0.0441388,-0.02565278,-0.05753124,-0.06913372,0.046457477,0.08079866,-0.034576025,0.09579497,-0.022880731,0.028813278,0.02745113,-0.007424191,0.10692564,-0.0159952,0.03683744,0.04974571,-0.022453865,-0.052176893,-0.08508429,-0.017414682,0.056760214,-0.002703189,-0.03055639,0.043173406,0.049023602,0.00828749,0.06799049,-0.12651837,0.054308806,0.093147494,0.034065604,-0.036354396,-0.0007310029,-0.042821534,-0.030708555,0.03353312,0.04824512,-3.716021e-08,0.051188592,-0.029216465,0.11438862,0.03213795,-0.02498931,0.04067431,-0.017429575,-0.00077834306,0.0019002284,0.0033854668,0.030447848,0.09237915,-0.014103365,0.015866213,0.005694144,0.08686111,-0.0657851,0.062361322,-0.034030218,-0.014477508,0.009424427,-0.07554821,-0.064631864,0.020179935,-0.009770966,-0.01478646,-0.0073661203,-0.07607066,0.025077766,-0.03115761,-0.054156344,-0.007337678,-0.04660605,-0.0784951,-0.06268789,-0.007816388,-0.02645308,-0.042109225,0.05302328,0.03369762,0.020842616,0.07629254,-0.029743036,0.093376786,0.070112556,0.02458967,-0.008989535,0.041159023,-0.036888313,0.007143784,0.049262844,-0.013686622,-0.005662282,-0.006965264,-0.1285743,-0.056644578,-0.015195184,-0.019893778,0.03437316,-0.034716718,-0.055219278,0.06740068,0.13422705,0.008854784 +6.3.2.44,"The enzyme, characterized from the archaeon Methanosarcina mazei, is involved in the biosynthesis of pantothenate. It is different from EC 6.3.2.1, the AMP-forming pantoate-beta-alanine ligase found in bacteria and eukaryota. ",384,0.99999994,-0.017429596,-0.0030444644,-0.08215498,-0.076777354,0.0017985957,0.055055752,-0.07262499,-0.022853833,0.0565805,0.012551573,-0.07457341,-0.08473215,-0.070915915,0.0004903604,-0.037289917,0.024061142,-0.07530559,0.0034673996,-0.03227418,-0.05722258,0.05763185,0.061903123,-0.01825849,0.03357017,0.03436527,-0.038239144,0.043796927,-0.04233665,-0.056135528,-0.04952948,-0.049600888,0.0030006464,0.0025443141,-0.045262534,0.037435208,0.04289799,-0.04151142,-0.053635,0.05405938,-0.048888613,0.13071693,0.03609286,0.069854714,-0.029132476,-0.043277115,0.032706544,-0.032723356,-0.017496407,0.0016642403,-0.047319528,-0.09655816,-0.09210799,-0.011421634,-0.025001261,0.07979222,0.069021046,-0.012880534,-0.049928725,0.010688718,0.032488033,0.023174731,0.009787007,-0.03993121,0.040180773,-0.023201767,-0.0785972,0.05050465,-0.07434728,0.04698906,-0.053875145,-0.050455254,-0.060470782,0.047633316,0.029295208,-0.015840445,0.04113642,-0.02743054,0.027159946,0.012949762,-0.06942323,-0.030423084,0.032708857,0.0016182539,0.062492676,0.032795742,0.024511442,0.044030305,0.04514189,0.03496743,0.02159509,0.07850889,-0.021379018,-0.007748183,-0.07317213,-0.06309696,-0.023779431,0.04840366,0.012441249,0.024991302,0.008986447,0.057668667,0.060904857,-0.03317583,-0.08538192,-0.085784,0.0042994474,0.04384167,0.07269966,0.029259633,0.06865058,0.026473818,-0.028972685,0.0724533,0.0022219091,-0.06266084,0.07103867,0.016032476,-0.06815036,0.06250982,0.060151055,0.052034948,-0.10063589,0.083099104,0.03759713,-0.061555095,0.021822242,-0.1277011,-2.1880004e-34,0.07768902,0.007467469,0.03735283,-0.01014328,0.023298478,-0.02500552,-0.057350744,0.009120361,-0.04085526,-0.069859035,-0.14860119,-0.040068876,-0.011503286,0.03243268,-0.011882305,0.044210427,-0.030639727,-0.032427557,0.016261911,-0.026838223,-0.030210037,0.049511977,-0.089691855,0.0693012,0.051863577,-0.0054481113,0.018648876,0.0033726105,-0.034389965,0.036001004,0.06041061,-0.04879206,-0.06089606,0.06740332,0.00421013,0.026171694,0.0006992843,-0.060890075,-0.039737727,0.0862184,0.028870001,0.0123968385,0.020004695,0.025836183,0.034088742,-0.053535044,-0.02735991,0.07805363,0.050134342,0.027754107,-0.04558386,-0.0014000987,0.14222506,0.0034550123,-0.043616597,0.038236808,-0.011896781,-0.0030687647,0.1067133,0.05632307,-0.0026728492,0.102610536,-0.028757,0.0376457,-0.005769101,0.07398434,-0.056676332,-0.058133427,-0.0018276441,0.016804684,-0.034686096,-0.048728596,-0.0033892223,0.08650379,0.048927344,-0.06808123,-0.030955357,-0.029865013,-0.034743357,-0.01416884,0.08667663,0.009636529,0.001398476,0.0031896348,-0.048807528,8.568369e-06,-0.015632793,0.07265129,-0.044363376,0.050517365,0.11517477,-0.032678127,-0.015133749,0.059645105,-0.0025311927,-8.993609e-34,-0.012590834,-0.07726518,0.05358172,-0.056288708,-0.058626913,0.06845237,-0.008347856,-0.049033333,0.023559267,-0.032772124,0.0643476,-0.014597318,0.07239883,-0.071944624,0.031986713,-0.068723366,-0.019975824,0.041645553,0.014548145,0.026740767,-0.0059734993,0.0271895,-0.07426854,-0.069255136,0.04099404,-0.009671627,0.012063379,0.1063817,0.016255936,0.040557344,-0.00016972657,0.029410645,-0.05178224,-0.038445804,-0.07329385,0.014487779,-0.033231836,-0.03843526,-0.011498449,0.013988285,-0.038957793,0.06403743,0.049184404,0.05919528,0.05990445,0.015972553,-0.060562015,0.052374296,0.022531651,-0.030923419,-0.021252697,-0.029377423,0.04554377,-0.045351554,0.031839874,0.02062714,0.021424169,-0.009010844,0.0035226217,-0.03816197,-0.016608477,-0.032565966,0.082293056,0.03008097,0.06817495,0.06490071,-0.06391298,0.118846804,-0.039109673,0.030900657,0.023888893,-0.013696317,-0.006056486,0.04142555,-0.05239728,-0.024023594,-0.08429231,0.018587492,0.019618427,0.00854955,0.019589078,0.013414243,0.060207322,-0.08709935,-0.031365357,-0.013179972,0.089815535,0.087095164,-0.03993719,0.04926669,-0.021122864,-0.018805675,-0.099578775,0.051681582,0.032374397,-3.6521424e-08,0.08315641,-0.12611555,0.0063225175,-0.052028436,-0.034671802,0.016267927,0.042958543,0.049271856,0.047641598,-0.03179274,-0.058311652,0.055462677,0.01421908,0.00034345806,0.00835819,0.07528811,-0.020503568,0.036939472,-0.029915564,0.09412958,-0.0072744857,-0.014212523,-0.056599822,0.002259268,0.011279312,-0.056536485,-0.014629089,0.09978973,-0.052674733,-0.076295026,-0.089074485,0.014440677,0.018156886,-0.024393877,-0.15427275,0.05982448,-0.051765744,-0.04127659,-0.019322928,-0.014276367,0.081057705,-0.11321524,-0.03305189,-0.00071532716,0.007671896,-0.02353614,0.052528355,0.021384273,-0.06642407,-0.082186036,-0.0042405054,0.03247544,0.03809991,-0.043979477,-0.06015717,-0.043816764,0.0044038524,-0.06301422,0.0135381995,0.014144483,0.041163225,0.013020044,0.16351265,-0.007977811 +6.5.1.6,"The enzymes from the archaea Thermococcus fumicolans and Thermococcus onnurineus show high activity with either ATP or NAD+, and significantly lower activity with TTP, GTP, and CTP. The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP or NAD+, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. Different from EC 6.5.1.1, DNA ligase (ATP), EC 6.5.1.2, DNA ligase (NAD+) and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP).",384,1.0,-0.042533956,-0.056886185,-0.024423031,-0.053373497,0.01653225,0.004795999,-0.097702354,0.026304975,0.04098933,0.08870231,0.021237321,-0.011919028,-0.08428644,0.063519284,-0.058277067,0.0048304508,-0.14149329,0.024916088,0.039395295,-0.0040817163,0.09556357,0.033884265,-0.02742119,-0.002640117,0.008802557,0.075622,0.027200056,0.019988628,-0.038783476,-0.038057037,-0.07983841,-0.06781612,-0.02097502,-0.034783952,0.03474441,0.102647446,-0.031751975,0.004634435,0.052121542,0.020473167,0.05674877,-0.035048965,-0.013891147,0.035492223,-0.0646534,0.021699108,0.059477035,0.10089492,0.0684803,-0.032330032,0.0020085128,0.039047867,-0.0102238525,0.00083952333,-0.024256162,0.054794457,-0.0645365,-0.044648983,-0.0036368347,0.007681036,0.0044493116,0.0057343403,-0.024768285,0.043326285,0.096307546,-0.071688674,0.082155265,-0.05088758,0.0019277161,-0.0041218135,-0.08317497,-0.058853418,0.046047367,-0.0057785697,0.019660713,0.078216955,-0.014200151,-0.07776918,0.033228017,0.04379316,-0.020429166,-0.05472612,-0.016953073,0.043344732,0.013141884,-0.04847946,0.060479224,0.019771144,0.033282295,0.030357992,-0.015812691,-0.012871689,0.057872046,-0.06769326,-0.049725395,-0.019699285,-0.041510925,0.054532595,0.04294967,-0.0400037,-0.005253088,0.0096547725,-0.025867451,-0.069111705,0.0026615018,0.008913065,-0.059571728,0.052535962,0.054452695,0.040629715,-0.033937663,0.035348907,-0.009359247,-0.04373573,-0.0195692,0.070097804,-0.044726804,-0.08565374,-0.046538908,0.03453324,-0.023097849,-0.09906965,0.023168085,0.0691958,-0.109924816,0.033024114,-0.09412538,2.752136e-33,-0.0005779398,0.042907216,0.015002949,-0.010444392,0.045935325,-0.00056246837,-0.07020057,-0.0033427095,-0.09397901,0.0363752,-0.02397343,0.007109403,0.09480927,-0.02357066,-0.052645788,0.011306696,-0.022155879,0.030390965,-0.036541868,0.0033537326,-0.0121971555,0.06980889,0.076689,0.023054082,0.08583125,0.019957526,-0.074982814,0.006219188,0.040964656,-0.012428125,-0.008515608,-0.1316374,-0.11284958,-0.008692666,0.075381495,-0.00964243,-0.037094302,-0.047077004,-0.02549711,0.049602255,-0.10525764,-0.006422448,0.008451351,-0.02710993,0.029321976,-0.037961744,-0.0049142325,0.064943895,-0.03668122,0.05991759,0.05465442,-0.0901938,0.10632501,-0.017944073,-0.04637677,-0.024980592,-0.04154682,-0.0626,-0.017178323,0.09093242,0.011225773,0.036353905,-0.03638694,0.0031437392,-0.045428652,0.058321755,-0.020479178,-0.02214815,0.0860389,0.05673581,-0.054357544,0.056024835,0.044830576,-0.0063929134,0.018025622,0.05724136,-0.05919019,-0.0056479876,-0.022867238,0.04830042,0.008106316,-0.053177536,0.061094,0.0048910542,-0.030950665,0.049215715,-0.041426614,-0.027571758,0.030149126,0.08142292,0.08472945,-0.07120733,0.019414114,0.011222146,0.048904147,-3.9166215e-33,0.111263715,-0.14402884,0.0069396296,-0.118311204,-0.067932606,0.016487861,0.023704508,-0.0030296487,-0.041712567,-0.14409664,0.07261009,0.016323423,0.023085063,-0.024873815,-0.03306423,-0.067455724,0.06664876,0.10076328,0.026099725,0.03215441,0.08878285,0.055232134,-0.056339636,0.039104275,0.040833116,-0.01357962,0.002899421,0.013928995,0.05531953,0.039433006,-0.03406881,0.04486814,-0.008674447,0.004486482,0.021577768,0.061289676,-0.01858801,0.012453513,0.07844273,-0.017146917,0.036685906,0.07572372,-0.00626092,-0.0011132626,-0.011535722,0.06528407,-0.04077087,0.060082536,-0.03533301,-0.0148429675,0.074018136,-0.04300051,-0.022442505,0.0054209526,9.112083e-05,-0.004834442,-0.008733859,0.010360637,-0.003781834,0.038376644,-0.025787886,-0.100966424,0.024499219,-0.02441238,0.052761536,0.005844026,-0.06667857,0.011446492,-0.014277903,-0.008763701,-0.012268285,0.035690278,0.022561576,-0.0006322205,0.01977674,0.02947451,-0.03380168,-0.038769737,0.048765887,0.006739413,-0.03834236,-0.0038149941,-0.038725134,-0.0330649,0.07780894,0.014903579,0.07646534,0.058117107,-0.024209457,-0.004012833,0.0080435155,0.0015150808,-0.014622138,0.03473525,-0.026562715,-5.2430345e-08,0.110181965,-0.050005507,0.033542432,-0.079363644,0.03676853,0.12988542,0.019491432,-0.005401941,0.08591011,-0.042740583,0.047274504,0.11454266,0.012818248,-0.014266653,0.024855893,-0.020872928,-0.10675646,4.420194e-06,-0.015198419,-0.06169681,-0.12627064,-0.019779926,-0.13694191,0.044801664,0.028802428,-0.014446287,0.04753414,0.020716412,-0.012110212,-0.02220554,-0.008164468,-0.034882195,-0.05114231,-0.008709305,-0.03646855,0.024109125,-0.015837573,0.0010678588,-0.068107285,0.045194406,0.06308984,0.02242306,-0.058928873,0.020838274,-0.0003443982,0.05623919,0.0019501833,0.04877565,-0.07555543,0.020788852,0.06622285,0.00047117786,-0.011663382,-0.062859975,-0.097694896,-0.07843852,0.03756229,-0.06911742,-0.046782546,0.030213423,0.016042452,-0.025055785,0.16535585,-0.02482057 +6.5.1.7,"The enzymes from the archaea Hyperthermus butylicus and Sulfophobococcus zilligii are active with ATP, ADP or GTP. They show no activity with NAD+. The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, ADP, or GTP, forming a phosphoramide bond between adenylate/guanylate and a lysine residue. The nucleotide is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine/guanosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the nucleotide. Different from EC 6.5.1.1, DNA ligase (ATP), and EC 6.5.1.6, DNA ligase (ATP or NAD+), which cannot utilize GTP.",384,1.0,-0.09964127,-0.045091055,-0.025338897,-0.0592141,0.0018211763,-0.015942624,-0.06651435,-0.007878321,0.020029811,0.062209252,0.05468759,0.018483961,-0.09265177,0.05180406,-0.05331859,0.03928687,-0.08215303,0.04312344,0.050696258,0.017364616,0.1204811,0.04246343,-0.03150207,-0.03737663,0.0175561,0.06901069,0.013137727,0.012721738,-0.047785074,-0.053378932,-0.05056397,-0.10005085,-0.055370905,-0.045803912,0.059264578,0.10381778,-0.030868018,-0.026939537,0.024271324,-0.0048014782,0.07774201,-0.01288089,-0.061104134,0.034952167,-0.06339169,-6.399051e-05,0.009553126,0.09329297,0.033266403,-0.060372066,-0.02377487,0.007240897,-0.010472859,0.0070785834,-0.03449216,0.057999115,-0.09502175,-0.06301695,-0.0094324155,-0.03840239,-0.013118797,-0.011713555,-0.0033243007,0.0059706597,0.08302462,-0.04959668,0.08993456,-0.06584804,-0.00047652907,0.00022312407,-0.103278,-0.0568612,-0.009769867,0.021190079,-0.03683542,0.083638884,-0.030633705,-0.04791233,0.08326268,0.01717086,0.01849025,-0.024940575,-0.012307918,0.08919267,0.04805113,-0.07162932,0.069118336,0.0566683,0.028897878,-0.025058582,0.01700086,0.004663805,0.036108185,-0.03371429,-0.06250705,-0.008745796,-0.03805832,0.07289871,0.013400835,-0.029312233,0.035846546,0.027622655,0.012573329,-0.100604825,-0.0013655757,-0.011526557,-0.052487306,0.10102146,0.033526737,0.046942472,-0.076578215,0.01646286,-0.0021016665,-0.02911011,-0.028122587,0.076507255,-0.02378584,-0.0396499,-0.093507245,0.025771104,-0.0071231565,-0.08354859,-0.00039395344,0.022256544,-0.047277063,0.04980955,-0.11539972,3.7342675e-33,0.036761936,0.01055849,0.005337885,-0.014990604,0.035232164,0.06332168,-0.073328406,0.025724757,-0.073150426,0.04285439,-0.03520788,-0.04338546,0.082931094,-0.011727402,-0.055960227,0.021525787,-0.013861454,0.023648864,0.010608437,-0.0013384533,-0.01486251,0.06917789,0.02244345,0.0098307645,0.052136168,0.033512425,-0.111255504,-0.050075162,0.04359406,0.00026128182,0.026282238,-0.16093874,-0.13306864,0.013839225,0.078345895,0.010700102,-0.015389485,-0.072233826,0.0030401582,0.018439962,-0.12132696,0.0049529104,0.029461797,-0.041559532,0.04101222,-0.031176584,-0.021798473,0.063632265,-0.0009153585,0.042248316,0.06179038,-0.10096477,0.10174996,0.00093692075,-0.049348105,0.022636177,-0.045037616,-0.021740517,-0.035115607,0.08174124,0.05176315,0.06464526,-0.026622,0.017798007,-0.028001852,0.077770926,-0.0634382,-0.036642917,0.066791445,0.092375584,-0.021580918,0.02031658,0.047322046,0.02666092,-0.0196836,0.015918357,-0.020035671,0.0044158115,0.007064772,0.058998253,-0.026915677,-0.07257411,0.03831034,0.0033115896,-0.037869483,0.059299752,-0.030415652,-0.018140936,0.039435208,0.042424694,0.11541902,-0.027072765,-0.04749609,-0.03327927,0.031128628,-4.7607933e-33,0.14396444,-0.097140506,0.029447189,-0.12604131,-0.036143497,0.046470568,0.035962462,-0.028626688,-0.03470411,-0.15020196,0.085665315,0.025115969,-0.0017971629,-0.008847857,-0.0031651019,-0.034195844,0.028265836,0.0773425,0.019940771,0.0007645952,0.08364682,0.06507975,-0.019552246,0.049184885,0.057080843,-0.058198676,0.027835634,0.012737031,0.07915314,0.033112016,-0.02907191,0.055212066,-0.041982736,-0.03377568,0.044004507,0.052981358,-0.014694486,0.031319443,0.02289703,-0.0088440245,0.0034574072,0.03851285,-0.011304102,0.024071448,0.043833062,0.05035454,-0.04083109,0.030261062,-0.044269446,-0.049681406,0.06778487,-0.03822986,-0.021558186,0.0076124114,0.032265168,0.024116017,0.0027362336,-0.013609815,-0.046588615,0.02383556,-0.011764792,-0.0524127,-0.0031300029,-0.040736556,0.050589245,0.042990915,0.0009163351,-0.034858193,-0.036492117,-0.0398733,-0.016317246,0.02176064,0.0075225728,-0.010643232,-0.014505067,0.05311527,-0.054974705,-0.012005499,0.05690939,-0.045493476,0.004265093,0.016915321,-0.033920143,-0.011282678,0.051094558,-0.0064269523,0.057114363,0.0801378,0.008247302,0.007045423,-0.012639866,0.02277686,-0.013956856,0.059766013,-0.032463703,-5.4079447e-08,0.09771339,-0.013589744,0.030380089,-0.090599954,0.026267525,0.1483166,0.015831154,-0.055093843,0.098464504,-0.0031893472,0.054449644,0.117473416,0.0016241054,0.022605017,0.032864165,-0.00066928705,-0.05508327,-0.011854388,-0.015585254,-0.03957293,-0.118565634,0.0035681257,-0.14125657,0.080366336,0.04187146,-0.052951418,0.054202672,0.0010840802,0.01620127,-0.02559548,0.021111129,-0.007977941,0.0020080209,-0.0008787263,-0.022674132,0.042520873,-0.05354191,-0.02459115,-0.03922467,0.03830156,-0.0045988676,-0.0009918242,-0.037412766,-0.006872139,0.02580519,0.052540757,-0.0010622989,0.0059299604,-0.08624943,0.05535589,0.0294438,0.0046943133,0.011277119,-0.08968456,-0.0656925,-0.039533075,0.036634155,-0.06628731,-0.052554518,0.024345992,0.020289822,-0.02851934,0.12490658,-0.03319635 +1.1.1.379,"The enzyme, found in bacteria and fungi, can also accept a number of substituted mandelate derivatives, such as 3-hydroxymandelate, 4-hydroxymandelate, 2-methoxymandelate, 4-hydroxy-3-methoxymandelate and 3-hydroxy-4-methoxymandelate. The enzyme has no activity with (S)-mandelate (cf. EC 1.1.99.31, (S)-mandelate dehydrogenase) [1,2]. The enzyme transfers the pro-R-hydrogen from NADH [2].",384,1.0,-0.05497145,-0.032771055,-0.13067889,-0.028330877,0.07589544,0.07345899,-0.09216936,0.06959368,0.01493747,0.046007764,0.015387609,-0.0011087812,-0.06261449,0.05075904,0.040138293,0.037478365,-0.022165611,0.026334248,0.10986295,0.006650995,0.014627311,-0.01059528,0.0017005646,0.006386295,0.034441955,0.042987615,0.06087608,0.02403082,0.0038711783,-0.020542545,0.02000129,-0.036518175,0.02200639,-0.060255192,0.08528697,0.05902162,-0.08406291,-0.03696369,-0.0080589,-0.0009651182,0.0704482,0.02872066,0.0040444667,-0.029777948,-0.03777205,-0.06908208,-0.012271291,0.069458425,-0.0064089224,-0.007913339,-0.024407974,-0.037562978,-0.053058963,-0.0025872656,0.00680819,-0.027714465,0.022253081,-0.0033863354,-0.018389417,-0.035231683,0.059407935,-0.034970947,-0.04802813,0.013082068,0.0102852695,-0.08192094,0.058810484,-0.033923853,0.06344582,0.012403353,-0.06884907,-0.073614046,0.041786063,0.004630874,-0.05763888,0.034209315,0.022085568,-0.067376785,0.036895007,-0.020725673,-0.014933217,-0.0030718583,0.117420144,0.016836884,0.08073452,0.042369533,0.004569118,-0.017521981,0.06264912,-0.011032801,0.009779401,-0.037737522,-0.025958285,-0.03785811,-0.19080523,0.056245256,0.028777072,0.08910292,0.048555594,-0.014700223,0.020774355,0.10584804,-0.040069837,-0.10013118,-0.02744167,0.04825817,-0.013548511,0.12210564,-0.0019719608,0.018640028,-0.024857571,0.0066019944,0.07998801,0.09439197,-0.042287905,0.038182195,-0.0065341503,-0.11924962,-0.093272164,0.043022174,0.015322206,-0.053280424,0.065724745,-0.029388824,-0.04879754,0.050218757,-0.055860195,-4.39673e-35,0.091056965,0.0010556104,-0.004122291,-0.0032264742,0.031135628,0.018830122,-0.078804575,-0.003143505,-0.071291976,0.007766086,-0.016265614,-0.07309621,0.062996686,0.021616492,-0.04147885,-0.022796497,0.009439892,-0.074869,0.062459454,0.07459689,0.03020337,0.08553587,0.00507672,0.05030853,0.02139006,0.04660826,0.055274926,0.056468856,0.07961381,0.02335582,-0.0035066004,-0.10092349,-0.09059592,0.017271714,0.052481752,-0.0057016234,-0.10482276,-0.077314295,-0.0015325898,0.0034015568,0.028089512,0.016117727,-0.046615407,-0.036220185,0.016700959,-0.08953193,0.06561342,0.08392175,0.02493609,0.028503716,0.009296511,0.004755668,0.021122184,-0.05857329,-0.07049093,0.041031145,-0.052288458,0.038696364,0.09496645,0.023679096,-0.0016502255,-0.0004571536,-0.035783462,0.007812449,0.09600554,-0.014124391,-0.07691506,-0.05808785,0.024788762,0.010976036,0.010674579,-0.052388832,0.07780506,0.06877416,0.047526192,-0.04654866,0.0077841086,0.019242799,0.061271954,-0.04389721,0.006484723,0.018362336,-0.0090771075,0.032438427,-0.029341646,-0.04021972,-0.04035306,-0.06376461,-0.008114658,0.022214955,0.045425512,-0.10494836,-0.02793109,-0.013716019,-0.00930796,-1.9018262e-33,0.053595405,-0.01265454,0.031467702,-0.07966425,-0.01298632,0.09857969,0.033573754,-0.027442046,0.021483602,-0.1045486,0.10472486,0.020588115,0.0056350194,-0.019125069,0.05123217,0.01773398,-0.008460013,-0.021736946,-0.054246724,0.0032155958,0.051239394,0.075527,0.02324183,0.013087862,0.015570326,0.01584856,-0.01978094,0.030522346,0.06363524,0.11103228,-0.016063482,0.07661474,-0.026268892,-0.03327194,-0.04451038,0.045684393,-0.041830584,0.03201536,-0.010267167,0.049890008,0.0020524652,-0.006063886,0.03398574,-0.020950036,0.09142993,0.0518148,-0.12804538,-0.014106653,0.006316383,-0.056991886,-0.06444469,-0.04158284,-0.09691063,-0.03868545,0.04098347,-0.012063573,0.007886623,-0.059275188,0.05454845,-0.037246566,0.0015076558,-0.013534719,0.029624121,0.027989792,0.010916548,0.07462116,-0.0026276659,-0.021915963,0.043013874,-0.022788325,0.060695615,0.008665767,0.0056516645,0.02888224,-0.012600347,-0.049113348,-0.07682797,-0.037542604,-0.038195457,-0.10929463,0.006316745,-0.018039118,0.021292368,-0.06532838,-0.0071419193,-0.050701026,0.029425789,0.047503304,-0.0020587423,-0.007398879,-0.0034612436,-0.012831603,-0.033641662,0.01999075,0.08831431,-4.7977174e-08,0.003897397,-0.06978658,0.099572085,-0.049833458,-0.0056092106,0.034380186,0.0048470204,-0.08349545,0.07111007,0.011089374,0.036720026,0.061897147,0.031892456,-0.00036850534,0.00569078,0.013322396,-0.0064342446,0.017272552,-0.09698824,-0.010951967,-0.08839918,0.027576074,-0.06577332,0.01728817,0.072641596,-0.007829081,-0.06575693,-0.010526134,-0.03009495,-0.07582478,0.024350416,0.06773911,0.055251155,0.014207109,-0.05115956,0.01476484,0.025485298,0.01610358,-0.03860364,0.031905178,0.032595206,-0.08457677,-0.041396353,0.05611944,0.035300374,0.038014375,-0.023223959,0.035547536,-0.08759031,-0.020294096,0.03417677,-0.024393382,-0.08965185,-0.09619758,-0.04913717,0.013859918,-0.04991082,-0.086853236,-0.0373441,-0.12126275,0.02962297,-0.064657,0.117031574,-0.095000684 +1.1.1.380,"The enzyme, characterized from the bacterium Halomonas elongata, participates in a pathway for L-gulonate degradation.",384,1.0,-0.049773067,-0.057650585,-0.05375613,-0.01027171,0.05930826,0.06658749,-0.056262985,0.030832926,0.0086449105,-0.041182686,0.037128102,-0.032355726,-0.038566113,0.04088385,-0.07239319,0.056461126,-0.05531096,-0.01722823,-0.008992378,0.0050348756,0.10066559,0.032141387,-0.10492165,0.033894807,0.0684727,0.05881567,0.039487373,-0.0845449,-0.041794393,-0.11630463,-0.03475216,0.009905491,0.09868867,0.0034816645,0.097393215,0.102658525,-0.026096871,-0.060261793,0.095703855,-0.01051283,0.02352338,-0.007351294,-0.009833148,-0.051794596,-0.0019180641,0.010225815,-0.0057051973,-0.010315552,-0.041876897,-0.033401128,-0.03891795,-0.103756994,0.0016858086,-0.013791611,-0.0050644744,0.03444668,-0.020496095,0.013456926,-0.032855902,0.032134533,0.056635503,0.028530775,0.0054628025,0.00397328,-0.038150564,-0.07092889,0.11810236,-0.04860186,0.008569786,0.011294852,-0.060330138,-0.07652388,-0.027895952,0.0032814469,-0.0067849583,0.034619458,0.04422867,-0.012868644,0.007952539,0.005816067,0.064058475,0.0601428,0.05987385,-0.039566558,0.059522502,-0.048464373,0.03249506,0.003151211,0.09812905,0.01084871,0.01878604,0.011815945,-0.008631056,-0.07276358,-0.048350576,0.0642343,0.016518584,-0.06869971,0.009993627,-0.015044867,0.03350124,0.023692349,-0.022235334,-0.063442826,-0.025577169,0.01030597,0.0449838,0.081790954,0.040846284,-0.006655457,0.015958142,0.002639094,0.057471666,0.054662313,-0.012030205,0.05931875,0.054113053,0.02694239,-0.08799765,0.091829605,-0.005649382,-0.045842715,-0.0049621905,-0.024644451,-0.09792005,0.040736113,-0.121936776,-1.605096e-33,0.11440268,-0.043879308,-0.10183165,-0.048335973,0.031365544,-0.036930997,-0.08408394,-0.016160766,-0.0958088,-0.09232222,-0.05018292,-0.026369734,-0.030330624,0.023000263,0.020775167,0.10932801,-0.022475302,0.026956396,0.006530613,-0.047994178,-0.021329902,-0.00014836954,-0.04033613,-0.013178715,0.0053855255,0.05610946,0.058941502,-0.05161744,-0.024906095,-0.012986109,0.0010764139,-0.05561845,-0.058813132,0.05751855,0.09854112,0.051672924,0.015427076,-0.052417222,-0.005009501,0.0055861226,0.008126193,0.09157655,-0.021121914,0.005743572,-0.00024782494,-0.050462905,0.0052293153,0.082141005,0.048853777,-0.00795295,0.0185618,-0.047912724,0.042533327,-0.022394858,-0.024722772,0.083640784,-0.040797513,0.02420798,0.026760021,-0.061490513,0.037815847,0.01425622,-0.003965393,0.027620722,0.059081703,0.012913744,-0.08090358,0.028029695,0.069933504,0.056290414,-0.07746533,-0.08366321,0.048967913,0.04177031,0.0052601225,-0.108907916,-0.032539997,-0.013651981,0.021646993,0.013596904,0.027531512,-0.031151153,0.015261684,-0.07507905,-0.062942915,0.008882753,0.02088121,-0.012675816,0.006298165,-0.0042900243,0.038909238,-0.025019133,-0.004310935,0.025152357,-0.025787614,3.6761219e-34,0.08985446,-0.07077495,0.025003225,0.018328078,-0.08202118,0.049645375,-0.039651185,-0.063594736,-0.015782831,-0.03215422,0.0007003515,0.036658473,0.059549093,-0.015180189,0.03181249,-0.01895573,0.06346237,-0.051953442,-0.053995576,-0.06764997,-0.0051778518,0.024774047,-0.015200157,-0.02051826,-0.0034933945,0.0023930937,-0.061529465,0.03493644,0.059720483,0.022026092,-0.040055797,0.027766714,-0.019630564,-0.088153556,-0.055930816,0.028231474,-0.007241362,0.0057067596,0.003215043,0.004341808,0.044892367,0.009621462,0.059030805,0.007918334,0.039703734,0.07093042,0.02523559,-0.026842922,-0.0018773704,-0.062047493,0.03055578,-0.001207743,-0.07061039,0.045189492,-0.027941525,-0.02112916,-0.012295429,-0.02448148,-0.09941969,-0.013326548,-0.05151032,-0.058578774,0.009840867,0.021765118,0.0698683,0.06889763,0.022756029,0.09454415,-0.013983692,-0.03594415,0.09683547,0.03379502,0.0551233,0.06364232,-0.048022214,-0.06876421,-0.12819783,-0.04396931,0.018023422,-0.094072714,0.041628793,-0.009705349,-0.052566845,-0.06672046,-0.0079030795,-0.1384872,0.020767065,0.10797131,0.04402421,0.032600887,-0.008984078,-0.07256643,-0.053493578,0.0011211168,0.07050361,-2.4149632e-08,0.017527679,0.030674864,-0.0036527137,0.0036773186,0.031050079,0.07749708,0.044142276,0.09119112,0.13502225,-0.0422298,-0.05705262,0.014898062,0.014012736,-0.00048324888,0.058955085,0.055610612,-0.01552864,0.0555552,-0.01013865,0.039572615,-0.06079597,-0.029239729,-0.06348297,0.06487011,-0.002465275,0.0038784198,0.030353049,0.11190667,-0.014702772,-0.036152847,-0.046120957,0.08291278,0.11202799,-0.02049094,-0.11674756,0.03514108,0.018226009,-0.044494182,-0.0010810976,0.052016586,-0.003035739,0.04900971,-0.10593346,-0.017500838,-0.040615138,0.045877464,0.07274338,0.009699838,-0.037374146,-0.0018532051,0.08104093,-0.05926385,0.0036872018,0.01575838,-0.08098615,-0.005953031,0.06193348,-0.043806005,0.016213503,-0.058558073,0.01466566,-0.015517976,0.15865439,-0.04347274 +1.1.1.381,"The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase).",384,1.0,-0.030603558,-0.120962,-0.07839774,-0.069171794,0.060111646,0.095157176,-0.121627025,0.07657638,0.049214043,0.033172365,-0.029423503,0.010615372,-0.059831608,0.047835376,0.00076868624,0.018284518,-0.0002458468,-0.025950933,0.048609633,-0.040927473,0.06407269,0.019883143,0.023963522,0.02442997,0.08316147,0.017378595,0.008319207,-0.02901246,-0.029835032,-0.06178586,-0.044939503,-0.06278059,0.03876292,0.011970164,0.045800675,0.07916363,-0.052211344,-0.066097625,0.09863934,0.041339714,-0.0018161867,-0.056492932,-0.04192903,-0.04209994,-0.0119142225,0.005958785,0.0020740784,0.0066864854,0.05532526,-0.0028119215,-0.04796084,-0.046044007,0.022440074,0.013974741,-0.046989672,-0.06268852,0.042201944,-0.0068780156,0.007773349,0.021896249,-0.028423628,-0.04879278,0.0487081,0.0065087597,0.034307923,-0.08703989,0.007690749,-0.044625357,-0.0016957436,-0.04655268,-0.09684862,-0.024631517,0.006104205,0.06597272,-0.006460923,0.023387449,0.02047366,-0.06062814,0.023170654,-0.04032325,0.07900728,-0.014352212,-0.02021808,0.13017024,0.033432823,-0.015066092,-0.04944922,0.049536843,0.086024456,0.07425642,0.004545861,0.03096111,-0.059439853,0.03344002,-0.039575003,0.035973575,-0.023796214,0.02576614,-0.04098524,-0.041095726,0.037069224,0.06327802,-0.004276739,-0.05736234,0.015349139,0.087935865,0.034200586,0.102996044,-0.012358758,-0.026522482,-0.0064305575,-0.0143635385,-0.0073464573,0.038778305,-0.098892875,0.053200852,0.1163475,-0.10935737,-0.09877982,-0.0737414,0.024269985,-0.023416499,0.12381891,0.009820859,-0.045666035,0.022450617,-0.026926072,1.9578771e-33,0.0704991,0.044456832,-0.028902058,-0.055382784,0.03342116,0.054325186,-0.10303629,0.069846556,0.010681755,-0.010101472,-0.06220194,-0.01934533,0.027442351,0.021830345,-0.013677417,0.0026604033,0.04076778,0.0029384075,0.009971199,-0.054187357,0.026496256,-0.03695476,-0.019265523,0.04625397,0.015019718,0.035235133,0.025566598,0.05511364,0.017886454,-0.040165775,0.016589437,-0.12943386,-0.035547446,0.030356351,0.063718215,-0.005048315,-0.10348625,0.010750421,-0.009957665,0.10556421,-0.022860775,0.06292987,0.021531181,-0.11845863,-0.02264297,-0.052605275,0.0066795126,0.09561772,-0.002821376,0.087057844,0.06795221,-0.050454725,0.044438828,-0.09294233,-0.039917532,0.040919367,-0.0036680265,0.04887006,0.04491424,0.052688543,-0.027035572,0.03530471,-0.005561756,0.064677104,-0.06385078,0.003090025,-0.1168746,-0.030106612,0.027546708,0.06925123,-0.012048909,0.009669567,0.084180504,-0.030366924,0.039729342,-0.044503067,-0.12357786,0.0027244014,0.007844341,-0.008266208,0.03069396,-0.042204946,0.03259595,0.053564403,-0.079334825,0.09416975,0.010590329,-0.04059173,0.0005108985,-0.00033315655,-0.0013873469,-0.07803285,0.035351474,-0.030656615,0.028850798,-3.1530072e-33,0.070337,-0.014039687,0.09077572,-0.12907997,-0.03660022,0.08095889,-0.0030343973,-0.01651944,-0.008148389,-0.026116043,0.10338764,-0.03547302,0.032872673,-0.07031772,0.056816667,0.0046332125,-0.05314463,0.023269325,-0.040576085,-0.005696372,0.045068916,0.0503939,-0.016138453,0.048572555,0.08045638,-0.02545104,-0.0004164886,0.033586178,0.07296151,0.05446707,-0.00873803,0.03182625,0.019729448,-0.027198331,0.004265025,0.04805159,-0.042890802,0.010956859,0.030589378,0.05428446,0.0023903958,0.0046031293,-0.0041302233,0.055341937,0.014267556,0.11483794,-0.106871784,-0.05473765,0.016946675,-0.042372685,0.014398518,-0.0414369,0.026273802,0.013753221,0.084723406,0.06106059,-0.023288868,0.015904699,-0.028596964,-0.07417513,-0.02111139,-0.06268142,-0.02679203,-0.023970352,0.032509524,-0.007843216,-0.10237835,0.025736233,0.03033045,-0.03127875,0.08883693,0.024477784,0.0032797332,-0.00786487,-0.05213969,-0.056552842,-0.0733439,-0.054933287,-0.028295878,0.018117175,-0.0052366536,0.011821019,-0.024019472,-0.07293575,-0.020277241,-0.03936351,-0.0108514,0.075862125,-0.05495557,0.051297247,-0.0516341,0.030504849,-0.090819605,0.048389334,0.039380457,-4.602001e-08,0.02441043,-0.04017006,0.035723474,-0.028967071,-0.0058086202,0.035899255,0.07539305,0.060981132,0.03278248,0.010474688,-0.032855146,0.058366433,-0.0025308426,-0.0054256646,0.03607934,-0.060387798,-0.06962737,0.012290368,-0.0065186988,0.014131202,-0.046757843,-0.021681402,-0.084891856,0.0013443092,0.018457402,-0.03312077,-0.0014241931,-0.023118744,0.01619536,-0.0017874637,-0.0404383,0.03908733,0.05119294,-0.07702952,-0.07777057,0.012007964,-0.07420088,-0.014329198,-0.06900635,0.07369359,0.056999933,0.0037166316,-0.08840063,0.053590227,-0.004071831,-0.00036784093,0.009390995,0.028702565,-0.02006926,-0.072390124,0.068002015,0.00048847136,-0.01692001,0.0101277465,-0.055494666,0.06920638,-0.0429075,-0.08908272,-0.066498995,-0.06858019,0.08236516,-0.03236399,0.14336699,-0.050090544 +1.1.3.47,"The enzyme, characterized from the bacterium Methylovorus sp. strain MP688, is involved in the degradation and detoxification of 5-(hydroxymethyl)furfural. The enzyme acts only on alcohol groups and requires the spontaneous hydration of aldehyde groups for their oxidation [3]. The enzyme has a broad substrate range that overlaps with EC 1.1.3.7, aryl-alcohol oxidase.",384,0.99999994,-0.020672178,-0.05268682,-0.055010527,0.06384112,0.1107632,0.046551667,-0.060311627,-0.0031396875,0.037206102,-0.040062983,0.008838019,0.021867614,-0.0894746,0.018253393,-0.028373143,0.053737782,-0.13083807,-0.08609302,-0.021677062,0.0032268309,0.08899034,-0.00035405107,-0.039826185,0.012202785,0.017128179,-0.013757847,0.04019543,0.038636945,-0.011306445,-0.073578045,0.08024793,-0.0014796086,0.025273405,-0.046458505,0.048980698,0.054880988,0.033156294,-0.04214188,0.06252618,0.009239322,0.022025615,0.008385307,-0.017606864,-0.049942162,-0.029244248,-0.0119365,0.028330548,0.008089333,0.012574861,-0.030522827,-0.027500147,-0.08108865,-0.023300013,0.01265072,-0.035855345,-0.057910744,0.018680312,-0.028465785,-0.04268022,0.036164984,0.030384103,0.0618977,-0.015941644,0.03551223,-0.010881464,-0.09181327,0.085307,-0.070829526,0.012175909,0.0017328677,-0.1318302,-0.10471355,0.0036031841,0.0078265,-0.024211165,-0.0005735821,-0.0075835474,-0.05717975,0.04764123,0.008351153,0.020054562,0.013325642,0.041804396,0.05683319,0.03184876,-0.07748421,0.039586738,-0.043546002,0.0923265,0.014311394,0.0049224333,0.04425882,-0.014155083,-0.09121323,-0.05327651,0.06130145,0.058678813,0.017709421,0.037617546,0.03145346,-0.01236615,0.022213465,-0.05557101,-0.100718625,-0.041391175,0.02509995,-0.01039784,0.12772936,0.0805417,-0.021283971,-0.032062363,-0.005379825,-0.0071696984,0.0075898543,0.033190113,0.091362804,0.014167829,-0.08746609,-0.08561701,0.012445333,-0.007945288,0.005014979,0.10372255,0.05798237,-0.09313756,0.060443915,-0.092132404,9.107251e-34,0.023435703,-0.042912874,-0.062494263,-0.055762365,-0.017124737,-0.03877568,-0.043777347,0.028637024,-0.05906147,0.03069019,-0.06445362,-0.06270314,0.065535165,-0.02237186,-0.024022182,-0.0055637644,-0.020058306,0.015330647,0.029828096,0.007826167,0.044605512,0.014522231,-0.019911848,-0.04008562,0.01311154,0.11530205,0.06365422,-0.0074678436,0.046706524,-0.013262276,0.028056303,-0.06388433,-0.14841412,-0.021287952,0.020131618,-0.0038328415,-0.0542372,0.016983418,0.00097213185,0.052508127,0.083072126,0.04905695,0.06384609,-0.027551794,0.05421256,-0.01843112,-0.06090998,0.12536645,0.047369685,0.047530685,0.0047825878,-0.0033750846,0.08600656,-0.01792862,-0.0700617,0.012458356,0.020604027,-0.025449956,0.009234749,-0.024830805,0.018924015,0.0041613462,-0.031339522,-0.054120187,-0.00090737967,0.026507232,0.040362295,0.0099889925,0.02955526,0.0736345,-0.095428966,0.03637645,0.075599395,0.021054136,-0.017652646,-0.03889325,-0.04825757,0.025768545,0.04735118,0.05093886,-0.082697116,-0.019894581,0.05496162,-0.036048897,-0.06553316,-0.06793653,-0.024761127,-0.0024214683,-0.028115515,0.025524417,0.06885183,-0.090852804,-0.010207109,0.025841435,0.0031335698,-2.1144216e-33,0.09178969,-0.08059121,0.008289379,-0.11981893,-0.023926187,0.08201293,0.042782735,0.066796996,-0.063472316,-0.014085414,0.051432107,0.0425968,0.043031096,-0.017915167,0.07586316,0.04847111,-0.01907934,0.019605728,0.036529258,-0.02689602,-0.0061771525,0.06807845,-0.030820098,0.035375345,0.065219134,-0.004936934,0.016127778,0.011438645,0.11488247,0.0125990175,0.016183738,-0.023374144,-0.0023345584,-0.0027064984,0.0066608447,0.08101866,-0.090833545,-0.002848375,-0.02147698,0.051144097,0.046153344,0.017434586,-0.021134838,0.06717141,0.025083756,0.05605342,-0.118412025,-0.04751606,-0.0040858723,-0.035457943,0.05296669,-0.0071539637,-0.014304764,0.013024706,-0.0004472837,0.012277522,-0.029211376,-0.0046651443,-0.08567158,0.020578861,-0.013987486,0.0054117045,0.011210324,-0.01547999,-0.008097113,0.0384201,-0.050144188,0.008525379,-0.06180516,-0.022991868,0.09052448,-0.0071410206,-0.03094226,0.038760263,-0.015467794,-0.03781087,-0.03208234,-0.034942806,-0.00542062,0.010625333,0.063507125,0.02269669,-0.03614102,-0.06445607,-0.015698804,-0.07778522,0.02740057,0.10812999,0.03342605,0.01280004,0.024888163,-0.04181052,-0.05924224,0.01882652,0.06529898,-3.995226e-08,-0.017499115,-0.06564906,0.080273405,0.013254614,-0.007364676,0.087777995,-0.0026856984,0.013452246,0.011552278,-0.024397206,0.01736322,0.020635977,0.009011136,0.06737071,-0.027757399,-0.02200711,-0.06287544,0.059603788,-0.013253159,0.004204047,-0.092242084,-0.013440064,-0.09221478,-0.012577599,0.03312607,-0.05044824,-0.012774945,0.05992358,-0.030181535,-0.08011719,-0.043104123,0.10807462,-0.05586353,0.032261565,-0.0870664,0.055117678,-0.03377289,-0.014251257,-0.08463371,0.070864394,0.024086878,-0.040851764,-0.11333663,-0.037494507,0.071873866,0.045315586,-0.013028331,-0.055637706,-0.014193801,0.056171786,0.06823342,-0.022339903,-0.010390602,-0.006805449,-0.12874329,-0.0018144496,-0.039844286,-0.05319629,-0.055547882,-0.039269336,0.07560945,-0.01112804,0.21231678,-0.016607413 +1.2.1.90,The enzyme is part of the modified Embden-Meyerhof-Parnas pathway of the archaeon Thermoproteus tenax. cf. EC 1.2.1.9 [glyceraldehyde-3-phosphate dehydrogenase (NADP+)].,384,0.99999994,-0.10328866,0.046901666,-0.07860068,-0.10492799,0.05247828,0.009481363,-0.13130139,0.005918063,0.01684554,0.012044359,0.0076971212,-0.064187795,-0.11944642,-0.018227305,-0.09431264,-0.0030136216,-0.06010607,-0.003923493,0.0624332,-0.023598282,0.042969663,0.11341717,-0.045900308,-0.027707098,0.090778254,0.010179043,0.010102096,0.005504621,-0.03856573,-0.029330067,-0.027438229,-0.063646145,0.08765776,0.0029425486,0.010478603,0.11322994,-0.03256504,-0.06226109,-0.008109162,0.03943778,0.05005882,-0.009268288,-0.031877328,-0.04177506,-0.09369821,-0.007713204,0.044100355,0.03352006,-0.02290484,0.056918718,-0.03746404,-0.08275685,-0.04377202,0.006847228,0.049029596,-0.0015452346,0.019715887,-0.03267568,-0.0767246,-0.10698754,0.09439016,-0.009285806,-0.041494235,0.042429022,0.00014845593,-0.059491783,0.03467092,-0.06035948,-0.01782148,-0.07448805,-0.04014094,-0.02642807,0.004168988,-0.017523248,-0.08794886,0.110688105,-0.046563365,-0.0070908843,0.08405536,-0.05699152,0.0691637,0.01644349,0.038970433,0.031081224,-0.022572387,0.0019808374,0.015425514,0.036821164,0.005377899,-0.012741028,0.047735933,-0.07475854,-0.031432286,0.0066384748,-0.064807996,0.091272555,0.020447196,-0.014836188,0.00044670215,-0.06863591,-0.02202192,0.06039752,0.02070291,-0.07677638,-0.06619039,0.01360143,-0.024616685,0.08334951,0.039824452,0.00014535467,-0.0333556,0.04543002,0.036498886,0.03895813,-0.006491046,0.045210518,-0.006487588,-0.06568215,-0.053445715,0.031736527,-0.058345445,0.013629462,0.03269594,0.07875066,-0.03740998,0.04514743,-0.109399945,7.0580014e-34,0.08949931,-0.013444915,-0.0117982635,-0.046657197,0.08548302,-0.0031156088,-0.08538063,-0.0030427033,-0.08700724,-0.028160017,-0.049133934,-0.06536932,0.06721351,-0.0074492395,-0.040015724,0.061120134,-0.034667894,0.0017549904,-0.00910767,-0.011932992,0.021694604,0.0769988,-0.053015202,0.008381839,0.06638458,0.0688455,0.015559986,0.017633341,0.0072615063,-0.010249921,0.042428985,-0.16100742,-0.1431322,0.005499456,0.14967136,-0.013009864,0.037994422,-0.06690796,-0.06599104,0.0031794722,0.02643073,-0.012635701,0.004932489,-0.024246851,0.069977,-0.01953297,-0.0044952533,0.10184608,0.046623845,0.025563704,-0.0033275685,0.021911552,0.09892486,-0.05904064,-0.07481715,0.067719355,-0.016991725,0.036027145,0.026191877,0.02597593,0.030365825,0.057791933,-0.00607624,0.04509111,0.03403771,0.02603957,-0.10328575,-0.022172486,0.054246545,0.09353545,-0.05169382,-0.012964664,0.017474778,0.013597002,-0.034189712,-0.031953324,0.025271717,-0.007429611,-0.045979504,-0.006733378,-0.039585635,-0.026378732,-0.0009292418,-0.037654653,-0.0004510351,0.035361998,0.0046530343,-0.014918427,0.018880108,0.11043719,0.069864996,-0.032658044,-0.064421706,0.009558219,0.003453677,-1.4528355e-33,0.052691568,-0.11533808,-0.0014003585,-0.04807643,-0.075774476,0.09277498,0.020139925,0.0049063265,-0.0029432126,-0.023192562,0.041474547,0.08691299,0.07042382,-0.117055215,0.045615055,0.012444774,0.021395434,0.041835967,0.013684521,-0.01317987,0.031072117,0.08834905,0.033989053,-0.032549165,-0.033684444,-0.007281825,0.04196485,0.083095714,-0.043180704,0.01913503,-0.017328987,0.04688154,-0.072474726,-0.025111413,-0.089974225,0.0043218625,-0.057283517,-5.2130792e-05,0.0475668,-0.009654091,0.013517231,0.026648892,-0.059222713,0.05897155,0.07014686,0.028717995,-0.07871456,0.011580923,0.004245109,-0.034566704,0.03887061,-0.01914188,0.035332944,0.06292762,0.0819422,-0.010649431,-0.01799846,0.058250546,0.044495877,0.012104225,-0.020745547,-0.022098674,0.051668417,0.0377726,0.08034136,0.06956773,-0.034710504,0.0510547,-0.011900787,0.035556246,0.06854117,0.016786758,-0.0031506398,0.056911495,0.02670548,0.0017168984,-0.024538433,0.023348223,0.009878491,-0.040372398,-0.02034473,0.035933368,0.011562219,-0.04460956,0.028433932,-0.05629476,0.044409707,0.15023568,-0.018735113,0.00945515,-0.0074536917,0.021911466,-0.06325114,0.010069092,0.030058905,-3.2890853e-08,0.0083203465,0.00062539073,0.052851442,-0.048108786,-0.0044958023,0.008176109,0.081221744,0.04123533,0.047095887,-0.033522367,0.029147979,0.079872206,0.071144305,0.015872324,0.059348647,0.0034449361,-0.026190113,-0.026731394,-0.023019178,-0.01063757,-0.05266511,-0.010163325,-0.050623685,0.053224444,0.049973384,0.01838555,0.034976795,-0.048380163,0.041253157,-0.030991193,-0.051706683,0.021803603,0.02548851,-0.06502968,-0.07132238,0.057286758,-0.032257788,0.013157914,-0.010712311,0.008886619,0.014012925,-0.05997657,0.009693221,0.00391445,-0.08350985,0.030544588,0.011498893,0.05142322,-0.031091342,0.010333959,0.036893222,-0.0062522446,0.018301649,-0.07817747,-0.14525959,-0.07505146,0.026286237,-0.10149502,-0.037963655,-0.009430677,0.040259223,-0.04160686,0.08784311,-0.03624456 +1.2.1.91,"The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 3.3.2.12, oxepin-CoA hydrolase. Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway.",384,1.0,-0.08180422,-0.06267593,-0.007487644,0.012544114,0.13008367,-0.02289423,-0.054026008,-0.011878113,0.045664754,-0.09022036,-0.008057244,-0.06420435,-0.05899351,0.048440296,-0.010605396,0.02688803,-0.09329661,0.038552277,-0.05613172,-0.08307909,0.055156432,0.0047603804,-0.02900411,0.052911136,0.059043337,0.0055203093,0.052072648,0.014288414,-0.044770952,-0.07190676,0.03566716,-0.059197206,0.022443486,-0.027961943,0.074252285,0.050830975,0.03828969,-0.1557928,0.07623355,0.012861575,0.0073554036,0.023082439,0.0143295415,-0.061468717,-0.0015205691,-0.043141756,-0.013044325,-0.021006254,0.08328303,-0.037530378,-0.022633696,-0.050508752,-0.06138462,0.019579552,0.045449246,-0.0015696702,-0.015240414,-0.07510546,-0.02545029,0.0190424,0.015454492,0.0214101,0.052498627,0.046628147,0.009526261,-0.113926604,0.037303638,-0.05134393,0.0060587847,-0.026125304,-0.11194009,-0.07673991,0.0666401,0.04550259,-0.0043471702,0.00797744,0.01690229,-0.08275942,0.012650685,-0.0020520212,-0.030222997,-0.0033021308,-0.03015098,0.078768015,0.009251791,-0.064699516,-0.038131658,-0.05399572,0.007930357,0.014984273,-0.034325503,-0.008527498,0.03417716,-0.0060034823,-0.008401594,0.06783832,0.017863898,0.005746764,0.023614038,-0.011023114,-0.0515871,0.1328293,0.0323476,-0.07037486,0.024168665,-0.021249946,0.0038691168,0.18996567,0.040348712,-0.008823647,0.015381299,-0.07494844,0.10277002,0.00983293,0.020710941,0.10018146,-0.0177471,-0.018947078,0.0038498568,0.041743744,0.021816544,-0.0391606,0.0565715,0.059029106,-0.0529777,-0.004129037,-0.05176672,3.130067e-33,0.0669013,-0.0044790227,-0.005997899,0.023440756,-0.014358645,-0.030873789,-0.1059585,0.051876202,-0.03395338,-0.013181554,-0.018657085,-0.024512429,0.06977803,0.019743199,-0.018740784,-0.10486126,-0.030352352,0.016444879,-0.0052253664,0.069048785,0.014994247,-0.0053335456,-0.0049154866,0.03952839,0.050898135,0.06654408,-0.0090199495,0.025846468,0.026178526,0.018440006,-0.009281445,-0.04875091,-0.115846194,-0.000645892,0.012117007,-0.08016247,-0.06431713,0.0058655716,-0.011847171,0.0905833,0.04097263,0.010544351,-0.050778788,-0.06372795,0.06592188,-0.0075324224,0.015241488,0.11215535,0.024157882,0.03340545,0.027753932,-0.026700938,0.11750703,-0.0647654,0.000689687,0.01779127,-0.024011813,0.027230091,0.087672696,-0.0070648068,-0.012763415,0.0875835,-0.055944946,0.06120789,-0.017204287,0.028895773,-0.012148631,-0.06749708,0.035263136,0.09656637,-0.060323138,0.06496681,0.030590866,0.012449057,0.0776521,-0.08319228,-0.04392708,0.032399412,0.046572026,0.032306265,-0.0043808552,0.019752046,0.0040325793,-0.029464751,0.00037823548,0.051454075,-0.01679933,0.03394609,-0.017087251,0.08983271,0.065553196,-0.106813796,-0.0025030037,-0.041941646,-0.025190402,-3.0023048e-33,0.109089136,-0.122231714,0.0029416513,-0.15188907,-0.10577792,0.021243952,-0.028524142,0.020788468,-0.022131938,-0.017288545,0.06267439,0.018330654,0.035298936,-0.05153703,0.0025999253,0.01740159,-0.041617237,-0.0016344097,-0.0043218397,0.024185698,0.06472598,0.032089572,0.01491859,-0.016023323,0.08363018,0.03471379,-0.01483512,0.015403318,0.049383007,0.012731568,-0.056510646,-0.053938616,-0.021743521,-0.002159386,-0.06815923,0.053975116,-0.08669265,0.024174716,0.03141868,-0.014623969,-0.014097639,0.025030011,-0.042231426,0.029173324,0.034290213,0.06706749,-0.040029682,0.0039167167,0.036029425,-0.028909096,-0.009095095,-0.059241887,-0.06939468,-0.03495553,-0.025795765,0.021095969,0.020051321,0.020206556,0.0016949987,-0.042193897,-0.04082656,-0.040261872,0.09859726,0.031074313,0.020221027,0.10494244,-0.043364555,0.07848127,0.036083557,-0.00049890054,0.07520686,0.007145204,0.05577391,-0.0032291592,0.02766477,-0.0322355,-0.051052146,0.025215972,-0.024938442,0.04223509,-0.06375649,-0.043669906,-0.04376815,-0.040670462,-0.030389626,-0.06321479,0.032745983,0.09039792,-0.0066497787,-0.002208975,-0.0059300964,-0.044625215,-0.03744762,0.021106217,0.037415843,-3.6581508e-08,0.003568299,-0.07108382,0.05908904,-0.023997065,0.06348299,0.09234021,0.00164114,-0.02844331,0.067825995,-0.010185845,0.037418593,0.072430626,0.047926906,-0.013784214,-0.002633341,-0.06704528,-0.029796591,0.0223992,0.024203978,-0.031939283,-0.013878206,-0.02088246,-0.045947462,0.092039876,0.048518334,-0.023530088,-0.0054331603,-0.018907744,-0.053467285,-0.081987105,-0.03216673,0.03540215,0.005128443,-0.0029295597,-0.033107046,-0.026179252,-0.0048390077,-0.023488285,-0.09852076,0.058160756,0.006982371,0.0067585027,-0.11235212,-0.028339092,0.02965251,0.057492685,0.013404012,-0.009263048,-0.037976656,-0.042441513,0.08464706,-0.066463135,0.005690408,0.02735824,-0.07211036,-0.028287368,0.009799915,-0.1077199,-0.054514077,0.0044850153,0.037305743,0.011885256,0.19699466,-0.026583087 +1.2.1.92,"The enzyme, characterized from the marine bacterium Vibrio sp. EJY3, is involved in a degradation pathway for 3,6-anhydro-alpha-L-galactose, a major component of the polysaccharides produced by red macroalgae, such as agarose and porphyran.",384,1.0,-0.043570172,-0.07430617,-0.090811014,-0.002198424,0.058883622,0.05903751,-0.018499969,0.024893878,0.034534104,-0.0015415327,-0.011677366,-0.04146682,-0.0897516,-0.014832075,-0.038521767,0.017312227,-0.006996491,0.053252287,-0.044538062,0.0053419787,0.15394068,0.028275758,-0.052762307,-0.014013849,0.028183227,-0.07541386,0.02959677,-0.06255979,-0.07713829,-0.06741917,-0.039599724,-0.02759497,0.12305974,-0.011720075,0.07445527,0.1018516,-0.019045273,-0.12410557,0.030446894,-0.01426357,-0.031789158,0.03617248,0.061727475,-0.016632674,-0.022922074,-0.0021243899,-0.018435813,0.027338706,0.057673022,-0.080807,-0.051161345,-0.09801887,-0.06686873,-0.037279498,0.031487647,0.016374076,-0.037555266,-0.12343746,-0.03962423,0.023613147,0.076462336,0.08696509,-0.0013763085,-0.00018830568,-0.049035378,-0.078175336,0.11693975,-0.018921606,-0.04100341,0.05127066,-0.12793124,-0.02260255,-0.058580086,-0.002519315,-0.0067042615,0.07467713,0.00516559,-0.016801551,0.04204778,-0.057194006,0.03351287,-0.0029921317,0.009309647,0.066961356,-0.027390413,-0.067770876,0.04997093,-0.021027116,0.03572791,0.046062622,0.025642134,0.00070082117,0.024636019,-0.049729634,-0.045609776,0.030490547,0.01137446,-0.06798483,0.12130695,-0.0028560106,-0.048611443,0.02244874,0.10311502,-0.08540188,-0.036500584,0.069971085,-0.023585394,0.15657885,0.09407745,0.065205924,-0.023586888,0.015751746,0.0083711725,-0.016246201,-0.053345695,0.108474046,-0.0046911514,-0.039788235,-0.04467946,0.033340067,0.055426814,-0.024970243,0.07822715,0.027606431,-0.04849751,0.021077786,-0.0005958273,-4.2146377e-35,0.037893884,-0.04676142,0.011069978,-0.008919796,0.013032418,0.021072442,-0.059131853,-0.05706103,-0.042722154,-0.0051576844,-0.12756619,-0.05597517,0.026108792,0.08309065,-0.0013520322,0.045120426,0.008112416,-0.05803373,-0.00848487,0.044131268,0.005641653,0.021444773,-0.003076593,-0.039716367,0.024373045,0.03553665,0.037548628,-0.02518005,-0.0139253065,-0.009932784,0.050649855,-0.05425697,-0.09862375,0.049060557,0.111830786,-0.013165849,-0.05880065,-0.03111346,-0.03063004,0.01102305,0.056973275,0.05490168,-0.05398897,-0.021780334,0.06340912,-0.041008707,-0.034944504,0.1101285,0.0455918,0.08778463,0.023340315,-0.0026635586,0.03578817,0.032260995,-0.056517042,0.03143093,0.01569568,0.06770685,0.0076953764,-0.02974893,-0.009238906,0.09586319,0.020909298,0.03104143,0.03731843,0.06498613,-0.0154147465,-0.0017832458,0.0038057535,0.029851323,-0.06936832,-0.03826375,0.0066614044,-0.015532838,-0.037639067,-0.07437353,-0.082758866,-0.030244432,0.008400569,-0.025274798,-0.03144934,0.007982018,0.04693606,-0.010682454,-0.08969845,-0.007911631,-0.029039169,0.026412787,0.0074305166,0.03803591,0.072225474,-0.057752732,0.00014781725,0.03386628,0.004019908,-2.5328011e-33,0.064441726,-0.037730258,0.060669355,-0.04260416,-0.028040567,0.006444151,0.020227013,-0.0059104743,-0.03413536,-0.036147952,0.00838929,0.031025067,0.012102674,-0.042402457,0.045019984,0.033430558,0.026176218,0.032873597,-0.07193519,-0.01007284,-0.024445321,0.047340915,0.07167796,0.0074490597,0.007693429,-0.03781262,-0.011251697,0.093359984,-0.06462511,0.023524974,0.07944409,0.016048025,-0.013023241,-0.055559833,-0.06986941,0.00091182964,-0.048310593,-0.004961449,0.05670427,0.04130834,0.049882773,0.068088956,0.020375995,0.0071979626,0.035511065,0.10184869,-0.07955791,0.033890244,0.021469438,-0.06089495,-0.00465912,-0.042562917,0.05399628,0.018143049,0.013913516,0.060982637,0.02542702,0.0034711796,-0.02915107,0.017167093,-0.05418627,-0.015134912,0.11199042,-0.013789492,0.07458915,0.03868941,0.032626208,0.06615896,0.026532786,-0.028252024,0.097303055,0.03979372,-0.061436757,0.044572443,0.001252932,-0.05075601,-0.12746838,-0.039358474,-0.053786207,0.0018316316,0.05739776,0.020678876,-0.01465153,-0.0559584,-0.03220522,-0.09192617,0.023812128,0.096481174,0.037111823,0.011720642,-0.03022156,-0.038450606,-0.07981813,-0.009282632,0.056515463,-3.414841e-08,0.06711796,-0.030298775,-0.01243632,-0.05239693,0.013538176,-0.011436917,0.004691764,0.10304779,0.055276327,-0.012707459,0.0012496038,0.0710514,-0.027363682,-0.016943589,0.031380735,-0.014687395,-0.037234895,0.028359987,-0.036966562,0.023905111,-0.026626028,-0.030683657,-0.10717108,0.023410177,0.010179154,-0.06983145,0.016696831,0.02651003,-0.02426159,-0.037387215,0.015419035,0.08817902,-0.015564118,0.0077397567,-0.14223482,0.009466882,-0.015571255,-0.032325976,-0.024864329,0.03596049,0.0006251086,-0.009138877,-0.031676468,-0.05274307,-0.034126718,0.061804175,-0.023081299,0.023698537,-0.017071934,0.01693123,-0.013422961,-0.01288624,-0.10428939,0.014677136,-0.0884466,-0.072216846,0.015602159,-0.0012169348,-0.031542666,-0.064178064,-0.007882301,-0.08181253,0.1522124,-0.04002384 +1.9.98.1,"The MtrC and OmcA proteins of the bacterium Shewanella oneidensis MR-1 are decaheme c-type cytochromes that reduce iron oxides extracellularly, passing the electrons to MtrA, another decaheme c-type cytochrome located in the periplasm.",384,1.0,-0.10686849,-0.019372245,-0.055231888,0.04672296,0.013263532,-0.02919838,-0.017565465,0.058240775,0.014392831,-0.029924497,0.022441875,-0.059255466,0.028531263,0.01696549,-0.029283341,0.015049775,-0.026081098,-0.03613443,0.07526141,0.047531586,0.05386478,0.028193478,-0.038428914,-0.010493292,-0.018456483,0.024509927,-0.025465975,0.036895234,-0.025725912,-0.097527705,-0.004363241,0.0074355463,0.09237737,0.01759193,-0.0026997952,0.0655899,0.018212752,-0.033832572,-0.009910986,-0.043322925,0.035856508,0.045417324,0.1096336,-0.03435067,-0.04611677,-0.054521803,0.08164021,0.04439853,0.039818544,-0.04222707,0.026598519,-0.032293573,-0.064326555,0.00063762354,-0.01313486,-0.039425135,-0.09633748,-0.058629606,0.003585634,-0.06360563,0.0060998267,0.02329492,-0.010916054,0.033284415,0.10837835,-0.05321439,0.014952385,-0.08919689,0.035647772,-0.029837571,0.013074294,-0.021411944,0.0032249962,0.021183608,-0.03451714,0.1587636,-0.009849513,-0.009326989,0.032391593,-0.0018732892,-0.051978055,-0.01648771,0.017346127,0.12124383,0.009805243,0.02247365,0.012756714,0.030981695,-0.030352077,-0.06592426,0.041271824,-0.013010749,-0.050884638,0.021464672,-0.11686736,-0.039088868,0.0044163647,0.06520258,-0.016784318,-0.015488394,0.022651058,0.099844076,0.014093014,0.028108016,-0.05663843,0.001276116,0.005947081,0.0751209,0.031273745,-0.002870835,0.046985343,0.02103943,-0.045606796,-0.061392725,-0.04952762,0.016069658,0.034955025,-0.0020492699,-0.019459525,0.0055857156,-0.08234062,-0.028482715,-0.01781376,0.006837559,0.010296868,-0.025332876,-0.1231804,2.8835813e-33,-0.010501544,0.0029798143,0.014042124,-0.032732215,0.037064392,-0.009049171,-0.010474658,-0.048828404,0.0074585774,-0.016895304,-0.06678675,0.05099954,0.0434328,0.0330956,-0.06322555,-0.048645962,0.03846263,-0.07490062,0.055752963,-0.049354617,0.014364387,0.10498011,0.033305988,-0.060686074,0.09393562,0.044668406,-0.0025439651,-0.0066357716,-0.007373866,0.044859022,-0.004062298,-0.06677321,-0.15476519,-0.007030825,0.048749093,0.006584017,-0.04330127,-0.050008602,-0.017162997,0.013589777,-0.033672422,0.025599714,-0.052271247,-0.04387851,0.008761292,-0.08227889,-0.04657989,0.09690247,-0.024776485,0.027863491,0.021919357,-0.010254588,-0.0021095392,-0.057858963,-0.09295865,0.0043450063,0.03321001,0.030121922,0.060602665,0.10010534,0.083965234,0.11449037,-0.051137224,0.087942354,0.090646826,-0.0016404006,-0.0067691025,-0.055612914,0.03538358,0.09306457,-0.059671234,-0.047177806,0.10395836,0.007372495,-0.030497769,0.03392539,-0.076424435,0.011160651,0.060980733,0.025527963,0.006954349,-0.08712422,-0.0117516555,-0.05708891,-0.040988818,0.050151315,0.09412631,-0.06328707,-0.058735836,0.020398283,0.07275287,-0.0077671674,0.013183696,-0.006985427,-0.064395204,-4.645072e-33,0.010795949,-0.075477056,0.08759362,-0.06461202,-0.066313684,0.046550192,0.0021692892,-0.018539798,-0.0207521,0.020092068,0.15136284,0.0009082595,0.0031751848,-0.08356228,0.045265745,-0.04133888,0.02718415,0.055624913,-0.017949637,0.005346396,-0.09136969,0.058298618,-0.0076557235,0.003766047,-0.052193496,0.00477578,0.03014348,-0.0057495045,0.034405857,0.0019870584,-0.02827675,0.11820723,-0.013327294,-0.11164924,-0.055188067,-0.023946123,-0.051981382,-0.0008876332,0.14712721,0.007139749,0.06923116,0.031410977,0.037296817,0.03800211,0.032555815,0.027878242,-0.12644719,0.059155293,0.04929327,0.026024025,-0.0047984137,0.011475767,-0.024147393,-0.0095336195,0.07094956,0.0055883126,0.051649418,-0.005906217,-0.0016418258,-0.01820065,-0.06265459,-0.0907402,0.015970584,0.03971534,0.07666918,0.10461051,0.004037301,-0.005608643,-0.0038674383,0.028957285,0.056399092,0.036013644,0.019412873,-0.09147214,-0.002806701,0.036148667,-0.09911527,-0.0151884835,0.040130906,-0.021931453,-0.01285438,-0.031242428,-0.03295648,-0.041181773,0.09861832,-0.06590003,-0.005080403,0.026848268,0.020109404,0.022283996,0.002157961,-0.04010613,-0.005457241,-0.026946617,-0.0027020248,-3.314732e-08,-0.0036594488,-0.100462854,0.03789096,-0.010827334,-0.054890983,0.022300927,-0.07469181,-0.04331846,0.09894128,0.04953937,0.058669124,0.089419656,-0.014143923,-0.07010052,0.002405903,0.08439301,-0.007688639,-0.036422424,0.0018470922,-0.004733444,-0.07464511,-0.022451054,0.04810678,-0.004059336,0.070844635,-0.057828043,0.048216175,0.03422046,0.0067335623,-0.038363874,-0.033153422,0.01222593,0.028003406,-0.026776591,-0.040583182,-0.0637234,0.030405177,-0.0033330603,-0.025532562,0.014009541,0.036660496,-0.02909093,-0.052340962,0.010626709,-0.009860798,0.024199937,0.032718025,0.10738311,-0.13912237,-0.08010953,-0.028531946,-0.0018515299,0.013624494,-0.06468517,-0.103415936,0.034493152,-0.016025951,-0.03596573,-0.02190665,0.035733145,0.013839161,-0.019672906,0.094509795,-0.06531892 +1.17.4.4,"The enzyme catalyses the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, peptidyl-glutamate 4-carboxylase, back to its phylloquinol active form. The enzyme forms a tight complex with EC 5.3.4.1, protein disulfide-isomerase, which transfers the required electrons from newly-synthesized proteins by catalysing the formation of disulfide bridges. The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2). Inhibited strongly by (S)-warfarin and ferulenol.",384,1.0,-0.02139711,0.035166625,-0.06240292,0.00809089,0.03572104,0.036452774,-0.046096258,0.0106893815,0.026985051,0.049725626,0.016605565,0.0068400153,-0.031065326,0.024377793,-0.04050088,0.0024080032,-0.07155513,0.063811384,-0.044170097,-0.015566481,-0.00703304,-0.09362168,-0.014435985,0.009142767,0.027508313,0.05821895,0.07126931,0.03404205,-0.039710913,-0.0022999726,0.012006202,-0.11846387,0.0853051,-0.025010217,-0.03924876,0.053130075,-0.022514185,-0.058938302,-0.033639316,-0.00016756436,-0.028103188,0.01930554,-0.076277345,-0.023729878,0.0595755,0.011515365,0.05333612,0.048022997,0.02726805,-0.020192517,-0.030279847,-0.033189505,-0.03470743,0.046332337,0.007286672,0.036357842,-0.116296925,0.033516455,-0.010354439,0.08749599,0.052564915,-0.060719956,0.014105632,0.020011237,-0.025842596,-0.026345683,0.008652756,0.003474702,0.017813835,-0.037088137,-0.0013355566,-0.07577967,0.041984268,-0.0014258884,0.016841874,0.040310014,-0.066648945,-0.033452947,0.0541225,-0.010911211,0.045600727,-0.018004078,-0.05643547,0.1283746,0.03992213,0.0026476933,-0.019218575,-0.05578769,0.04459983,0.04784294,0.045906972,-0.02200275,0.03213813,0.048785318,-0.056001313,0.048163168,0.024791816,0.059562184,-0.014859737,-0.019765476,-0.016421845,0.061853673,-0.0641118,-0.10582841,-0.0078390185,0.023023304,-0.012480539,0.09346747,-0.017489886,0.0047170236,-0.00607203,0.0083473185,-0.043205015,-0.005614244,-0.0072908015,0.074926145,0.107112244,-0.056212485,-0.0990099,0.09002492,0.026813338,0.031642724,0.055743728,0.009740193,-0.066946,-0.0046929047,0.024007887,1.5106984e-33,-0.0015032465,0.052139252,-0.013360547,0.038608477,0.037362583,-0.0031744817,-0.12287133,0.053737756,0.018545998,-0.06142544,-0.06038278,-0.04273213,0.07981371,0.00074091717,-0.03489579,-0.016231794,-0.006309306,-0.05018468,0.07181495,0.060378596,0.06491853,-0.020127073,-0.025946936,0.04682781,-0.028020004,0.09140538,-0.020184431,-0.0047445465,0.057795677,0.020106336,-0.005926177,-0.12756929,-0.059703946,-0.020083206,-0.019116724,0.011080081,-0.08122989,-0.014237856,-0.0016818127,0.07943228,-0.04851759,-0.025276233,-0.070554264,-0.006884559,0.06179569,-0.08269263,-0.00473118,0.12381812,0.045316115,0.009444335,0.04825125,0.0110862125,0.06864335,-0.015727466,-0.03926113,0.07775511,0.040490773,-0.041656774,0.039477523,-0.0077682384,-0.02396674,0.060274508,-0.025552837,0.036757205,-0.022255154,0.0043374323,-0.064312585,-0.055972442,-0.08357331,0.030833503,-0.02319955,0.038391132,0.06926536,-0.02111297,0.00021731961,-0.020124467,-0.07908143,0.0033629837,0.031248795,0.004988964,-0.06499171,0.015322669,0.048622455,0.04079186,-0.02529508,-0.05166612,-0.0441393,-0.016560989,0.039696574,0.0007936377,0.0032735576,-0.061318193,-0.029844625,-0.006140271,0.053193904,-2.5135607e-33,0.124823615,-0.06813551,0.039769594,-0.046715487,-0.004298099,0.11195704,-0.023039507,0.021000924,0.042910486,0.04485544,0.076291636,-0.057370808,0.037534073,0.002942012,0.0041123913,0.026434617,-0.048824843,0.108571716,-0.0065933648,-0.0732879,0.017956331,0.021916062,0.055490267,0.08913855,0.028439537,0.018476706,-0.001951415,-0.0048871175,0.074431956,0.112166025,-0.013238124,-0.09995435,-0.050012574,-0.028059185,0.010390111,0.09725225,-0.08198394,0.013102371,0.012078999,0.0212882,0.017331513,0.005775012,-0.017842738,-0.024534522,0.017162884,0.08475532,-0.041191444,0.08497654,0.0042691743,-0.099969454,0.061830174,0.058739714,-0.10074472,0.04128011,0.033662625,0.05698666,0.012748434,-0.0037242547,-0.011253106,0.0033176334,-0.070411496,-0.18043293,0.04824586,0.029499887,-0.009304486,-0.0017683147,0.0011011605,0.12835588,0.029678747,-0.035394616,0.04462182,-0.058999375,0.038844198,-0.022242472,-0.033351928,0.011499639,-0.043389034,-0.07402322,0.011157993,-0.042037603,0.02717469,-0.06928104,0.005645711,-0.015852489,-0.045608956,-0.069296926,-0.035267226,0.118230015,-0.029816907,0.04764041,-0.038299214,0.0020610797,-0.07434959,0.030299097,0.07752339,-3.9929915e-08,0.055901118,-0.0048116026,0.07538502,-0.031910703,-0.012138245,-0.01631426,-0.06621549,0.05783858,0.083636954,-0.0682067,0.062199656,0.069500275,-0.019266553,0.032569226,-0.033156484,0.036143973,-0.004689518,0.06264573,-0.009486363,-0.024909584,-0.05613737,-0.024372382,-0.050628185,-0.034998357,-0.009371698,-0.09324146,-0.011361564,0.007322415,-0.07077508,-0.05407318,-0.0020599787,0.021830808,0.006617013,0.0071074907,-0.120364994,0.02652697,-0.033906925,0.0061532347,-0.046880417,0.027598115,-0.03717904,-0.07942147,-0.048797596,0.042265054,0.004118153,0.027154911,0.07435672,0.048684586,-0.045426436,-0.031387478,0.00019332801,0.0120686265,-0.00059283565,-0.0934749,-0.11170974,0.06200927,-0.05099152,-0.08791241,0.021482581,-0.14007214,-0.04539189,0.03671259,0.10820339,0.01297039 +1.17.4.5,"Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)].",384,0.99999994,-0.022749148,0.04772508,-0.07912263,0.00452588,0.059423517,0.011087347,-0.031187795,0.033016406,0.033754118,0.06144228,0.027754234,0.026599076,-0.082416475,0.04176359,-0.058812432,0.034492902,0.018213548,0.10811076,-0.041205432,-0.0031893025,-0.043221638,-0.06567892,0.05972411,0.06631048,-0.0065438417,0.11767218,-0.00076256995,0.07662197,-0.033359233,0.029286973,-0.006819952,-0.038337823,0.039937332,-0.058787525,-0.04662684,0.04040892,-0.0007681629,-0.0033282458,-0.10755267,-0.0019355576,-0.024410382,-0.02273687,-0.0651092,-0.017924823,0.05200499,-0.012128459,-0.033363413,0.07943638,0.013113429,0.03048992,-0.0052354084,-0.06674617,-0.062210485,0.05184381,0.08827985,-0.022039339,-0.0789366,0.03304399,-0.001915347,0.055974927,0.012362993,-0.10935471,0.033796147,0.036452428,-0.038164057,-0.049231015,0.029212832,0.032711178,-0.031828053,-0.009894005,0.031403393,-0.0340345,0.075343564,-0.0007944444,-0.0070805103,0.08556407,-0.047237586,-0.0035857132,0.07920922,-0.065211914,0.0408077,0.01929887,0.0032283096,0.16130874,0.044141117,-0.029573178,-0.09927502,-0.05750243,0.02793464,0.038220566,0.03759334,-0.00017211732,0.039070733,0.07052581,-0.03966384,0.048037518,0.043413676,0.038611814,-0.061358295,0.021575747,-0.03211613,0.024802634,-0.09686024,-0.061397385,-0.020153232,-0.027808597,-0.03551238,0.073966324,-0.054449063,-0.0066995807,-0.009804273,0.020639233,-0.059423007,-0.008410378,-0.027268939,0.036304783,0.09416272,-0.0802201,-0.07275739,0.08694011,0.016939534,0.010978999,0.031923305,-0.0119751515,-0.035637457,-0.055974305,0.10664846,-5.55681e-34,0.031218216,0.050071664,-0.029409789,0.017868306,0.035874803,0.02317921,-0.06109815,-0.04515081,0.054275796,-0.05835714,-0.023782963,-0.011321138,0.07395873,0.03676081,-0.031052431,-0.03950953,0.0012269987,-0.0015190558,0.03734809,0.0347582,0.10691224,-0.040690314,-0.075833656,0.023486773,-0.06330287,0.02336657,-0.04424263,0.0309235,0.04248043,0.030957777,-0.021413228,-0.08188838,0.01423808,-0.029509565,-0.020351855,-0.00010051124,-0.11724123,-0.033583604,0.0020954446,0.08386209,0.0061168787,-0.0030213713,-0.06952915,-0.008646599,0.05211952,-0.08632068,0.019940747,0.06038857,-0.00047232286,-0.006719234,0.07955686,0.059978023,0.03153728,-0.040622924,-0.010312648,0.091696985,0.059158888,0.0005133769,0.048671313,-0.04773402,-0.06023995,0.045162868,-0.066778496,0.0546511,-0.062873125,-0.014931591,-0.06036625,-0.069960564,-0.13251202,0.00019811977,0.031498782,0.051148746,0.091973476,-0.006155092,-0.024065068,-0.019294212,-0.002659718,0.06555082,-0.0062839636,-0.017346026,-0.067321114,0.020177703,-0.0036916654,0.07015375,-0.06107996,-0.003160336,-0.025547376,-0.0430903,0.03278366,-0.028437542,0.023325069,-0.057457443,-0.011336176,-0.1005185,0.05621316,-4.8962026e-34,0.03701383,0.020276098,0.0407319,-0.03239101,-0.020621354,0.14485098,0.003649738,0.023799695,0.03488051,0.0070349593,0.0930578,-0.03396043,-0.056685023,0.0142348735,0.005263166,0.081336185,-0.043506682,0.08315163,-0.007018856,-0.05420011,0.07164994,-0.03464067,0.061504584,0.09386447,0.017229073,0.013345877,-0.0012236239,0.007862313,0.025253657,0.082195476,-0.0014295597,-0.098706916,-0.07064603,-0.031052731,0.025437744,0.054915544,-0.09281967,-0.03226144,-0.041029286,-0.010437508,0.0075288587,-0.037150316,-0.002365069,0.014516989,-0.026366444,0.071148425,-0.038735036,0.061406206,0.07115167,-0.06791984,-0.0045099426,0.07077519,-0.073326655,0.11980977,0.01637849,-0.027440064,-0.004889126,-0.010340351,-0.027393654,0.015766071,-0.028691873,-0.11026414,0.016138991,0.051608726,0.031441752,0.010860386,0.02000905,0.10570277,0.039644975,0.017166061,-0.000101183046,-0.051118564,0.061354093,-0.05502448,-0.0006452906,-0.05806577,-0.022754781,-0.0543565,-0.07860453,-0.019220008,0.052711613,-0.03537611,-0.037663464,-0.020682178,-0.039817695,-0.049902182,-0.028566163,0.10315675,-0.061502192,0.017592318,-0.011228046,-0.026626503,-0.076640345,-0.009668358,0.03715678,-3.4895717e-08,0.035062205,-0.018985936,0.08425051,-0.021809101,-0.06406005,-0.055699907,-0.06680941,0.0702805,0.03979733,-0.04215403,0.091547705,0.082158126,-0.0018109399,-0.011886651,-0.02260775,-0.0007130541,0.011586388,0.05631477,-0.0031457806,-0.05929703,-0.0019898983,0.004359249,0.05274869,-0.04935574,0.0048182416,-0.0034416039,0.00088205584,-0.093133144,0.006807235,-0.08168189,0.044721615,0.019451672,0.020737246,0.048921246,-0.09480448,0.0524578,-0.011479136,0.04906635,-0.09691481,0.04228939,-0.06427316,-0.026487676,-0.024539066,0.06299804,0.001436472,0.005682305,0.0424739,0.03969706,-0.039845552,-0.06507449,-0.034478478,0.05670472,-0.026488757,-0.07274373,-0.106191635,0.039543346,-0.030908622,-0.042933516,0.005269315,-0.09150336,-0.02281042,-0.026836045,0.073697686,0.048354536 +1.17.98.1,"Under physiological conditions, the reactions form deoxycholate. This enzyme is highly specific for bile-acid substrates and requires a free C-24 carboxy group and an unhindered 7alpha-hydroxy group on the B-ring of the steroid nucleus for activity, as found in cholate and chenodeoxycholate. The reaction is stimulated by the presence of NAD+ but is inhibited by excess NADH. This unusual regulation by the NAD+/NADH ratio is most likely the result of the intermediates being linked at C-24 by an anhydride bond to the 5'-diphosphate of 3'-phospho-ADP [2,5,6]. Allodeoxycholate is also formed as a side-product of the 7alpha-dehydroxylation of cholate [6]. The enzyme is present in intestinal anaerobic bacteria [6], even though its products are important in mammalian physiology.",384,0.99999994,-0.014600705,-0.078048415,-0.06966798,-0.0027277404,0.020697767,0.07824762,-0.07305383,0.02367308,-0.01668351,0.06754114,-0.004142243,-0.028811561,-0.068638645,0.03610552,-0.05199264,0.067819566,-0.06492968,-0.034454826,0.043702222,0.008267031,0.0025169728,-0.0007443587,0.01228261,0.009951771,0.077921316,0.012382723,0.07650268,-0.021924054,-0.06844515,-0.06342564,-0.03618234,-0.031403936,0.10805186,-0.0329082,0.002154125,0.071917124,-0.07877507,0.01090112,0.031302333,0.043240372,-0.021776618,0.02206492,-0.08177289,0.013380351,-0.03401619,-0.044790555,0.008178984,0.037413612,0.0530501,0.020833462,-0.036229342,0.0080280565,0.022064015,0.0024458633,0.042698212,0.020361725,-0.018504312,-0.019967342,-0.03698761,-0.0653503,-0.025710292,-0.07181415,0.028535172,-0.035883475,0.018775323,-0.035301905,0.10048141,-0.05260251,-0.011562984,-0.09670135,-0.07075012,-0.037819937,0.02039965,0.0010464645,-0.026549192,0.08515353,-0.0677384,-0.056104045,0.033465628,-0.006822967,0.01783849,-0.033948805,0.004911227,0.09422842,0.08737511,-0.04214888,0.007251872,0.050732836,0.0039767995,0.018737499,-0.029191235,-0.013166146,-0.063868955,-0.030139765,-0.065048344,-0.016896948,0.058789626,0.03464248,0.022458917,-0.05547002,0.044602565,0.12736277,-0.035992607,-0.08280745,0.010284112,0.038974185,0.033385742,0.070158646,-0.009773505,0.013216085,-0.001976612,0.012122436,0.03896126,-0.046359062,-0.034416392,0.12496053,0.0011790898,-0.047411047,-0.10257371,0.03376448,-0.0056623374,0.026012735,0.003051122,0.067758866,-0.027634157,0.006220919,-0.07920935,2.3630237e-33,0.069331475,0.05130882,-0.04098415,0.03928257,0.03411893,0.050435852,-0.077869564,0.037732065,-0.009300399,-0.022431502,-0.020129278,-0.04656027,0.094673,0.0048091677,-0.069482416,0.025865745,-0.0054210816,-0.06193002,0.07013812,-0.0034624045,-0.02178426,0.056863178,-0.07855287,0.010734504,-0.014418717,0.02263035,-0.031291965,0.09363998,0.0072665773,0.0029692715,-0.0036117737,-0.10922161,-0.050422776,-0.0064925817,0.09238714,-0.027556462,-0.107811674,0.0225169,-0.02893279,0.081426114,-0.006170524,-0.014573808,-0.031060047,-0.04836746,0.056777094,-0.07844633,-0.016826052,0.06922375,0.05673043,0.06832375,0.05644373,-0.054856233,0.10247262,-0.059834115,-0.053228926,-0.014774882,0.0089824805,-0.029463483,-0.014922996,0.09354288,0.043054406,0.022087043,-0.08313351,0.058721002,-0.054399967,0.003740954,-0.102451816,-0.073685266,-0.050483543,0.007801625,-0.023378743,-0.015523412,0.06469542,0.048439447,-0.06262032,0.008690191,-0.027717859,0.022120254,0.013644234,-0.03685817,-0.010074011,-0.016050914,-0.032492775,-0.02026335,-0.031636856,0.04994158,-0.025825659,-0.04754687,-0.02670801,0.03862068,0.03718313,-0.076891735,-0.07325092,-0.01289923,0.061590213,-5.028074e-33,0.09213381,-0.0742232,0.04306022,-0.14999658,-0.019604232,0.18550922,0.06795182,-0.045902308,0.05420696,-0.05565308,0.058460213,0.011630255,0.030533217,-0.033099987,0.037076876,0.041927617,0.013280721,0.09635788,0.0022404254,-0.04947512,0.03630124,0.13133432,-0.012686998,0.06352468,0.06299382,-0.0019155943,-0.026573664,0.023787607,0.060444057,0.15624858,-0.02044343,-0.01673848,-0.04723463,-0.00881981,0.034935135,0.06284566,-0.13266946,-0.030288232,-0.032364793,0.057265945,-0.08172435,-0.043344226,0.033232715,0.0005453729,0.062664874,0.03336242,-0.061965026,-0.02684239,-0.004135154,-0.011647619,0.06449489,-0.01356282,-0.0009788962,-0.0075406907,0.0357978,0.059222646,-0.07932016,-0.004161872,0.058024388,-0.08563856,0.0022129558,0.001995916,0.008004529,0.0016030694,-0.04910877,0.04103942,-0.052406512,-0.003400922,0.028168622,-0.07275223,0.0021159041,0.05331097,-0.012946051,0.07748194,-0.020828452,0.010686552,-0.08840345,0.014475443,0.007858408,0.0075832796,-0.05271014,0.017266043,0.025165655,-0.021455895,-0.03227872,-0.055756874,-0.016216826,0.02273298,-0.012171934,0.008853261,0.013942714,0.0078091384,-0.11746111,0.03354987,0.027480401,-5.330782e-08,0.06350533,-0.043354835,0.0056994027,-0.040984526,0.00940106,-0.040782295,0.047475178,-0.060180202,0.027703904,-0.012119174,0.024608236,0.1328215,0.024000363,0.035932314,0.0217037,0.018512154,-0.07307817,0.013127261,-0.03137001,-0.027306575,-0.067069225,-0.04340296,-0.0631244,0.05215293,0.03262248,-0.03740573,-0.012611423,0.012170166,0.019510098,-0.049392637,0.11930678,-0.03300876,-0.03976925,-0.06586325,-0.045843042,0.046536416,-0.023404112,-0.01890789,-0.016479101,0.08052047,-0.007318719,-0.065702654,-0.057449047,0.05347898,0.031491112,0.016101355,-0.03821055,0.03135019,-0.038064633,0.011541108,-0.0064828782,-0.005133638,-0.008147783,0.0049121045,-0.04580951,0.010877837,0.004062674,-0.09461191,-0.011428918,-0.049829133,0.010379082,0.0570036,0.14052144,-0.058939945 +1.17.99.6,"This enzyme catalyses the last step in the bacterial biosynthetic pathway to queuosine, the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. Two types of enzymes are known to catalyse this activity. QueG enzymes are cobalamin-dependent, while QueH enzymes contain a [4Fe-4S] metallocluster along with an adjacent coordinated iron metal.",384,0.99999994,-0.08284552,-0.0864675,-0.086668774,0.030717801,-0.023165181,0.014666863,0.044158064,0.052944157,0.028817866,-0.023145001,0.030863237,-0.023576524,-0.058260467,0.031278763,-0.035910744,0.023075545,-0.088512816,-0.031736292,0.019191008,-0.06908745,0.020947905,0.024009105,-0.05214386,-0.033509713,0.027004747,-0.011614738,0.022326432,-0.06618536,0.015552624,-0.057295438,-0.007259772,-0.0035275307,0.02282508,-0.0010882718,0.043229125,0.045927692,-0.026741423,-0.050498594,0.0694677,-0.033859655,0.028239269,0.014010316,0.033660747,-0.053382073,0.047810465,0.0037824386,0.050129928,0.042371243,0.0017992137,-0.026628789,-0.086357154,-0.0140598975,-0.0736455,0.011195127,-0.008083485,-0.025943704,-0.058171403,0.039524514,0.004746837,-0.004326632,0.07364336,0.0032105192,0.016869115,-0.011878356,0.048071492,-0.030443048,0.071108006,-0.0035531102,0.07772593,-0.010772296,-0.03677433,-0.02549202,-0.054360315,0.013695919,-0.049687255,0.11020725,0.009487107,-0.043610394,0.02804167,0.022215115,-0.0064869085,-0.0061735897,0.0636887,0.055553764,0.06513693,-0.029358475,-0.018130641,-0.03569626,0.11502314,0.07232473,0.06878533,0.0045392034,0.015234718,-0.104965,-0.08425945,0.044290937,0.0005035712,0.051687364,0.061677244,8.497734e-06,-0.006475907,0.0076654577,0.022149485,-0.009164464,-0.025876548,0.06708939,0.06956237,0.034710206,0.09680176,0.001308013,-0.034237932,0.024433834,0.07395313,-0.004059442,-0.009505036,0.08242637,0.0065818275,-0.043605182,-0.046470474,0.012191604,0.04135314,0.03534863,-0.035489537,-0.012654555,0.017288428,0.0046152603,-0.10730899,3.9954667e-33,0.063589625,0.067010075,0.019086689,-0.10298153,0.03823661,-0.037104934,-0.07104674,0.07754541,-0.06390958,0.049857687,-0.05624816,-0.10843847,0.027598584,-0.0015995188,-0.00976386,-0.035493534,-0.057853244,0.0010476972,-0.0075236685,0.026064185,-0.008876172,0.049422048,-0.0607625,0.031254444,0.05198741,0.06872027,-0.017319722,0.036556482,-0.060831174,-0.02557109,-0.0064116023,-0.08263967,-0.100333035,0.015250949,0.070731565,-0.06931212,-0.013349718,0.0030203834,-0.030245813,-0.03527086,0.006348958,0.037369076,-0.032922067,0.0019012827,-0.0018927299,-0.085420266,-0.06027898,0.064433195,0.047784157,-0.0448929,0.040150564,-0.04878937,0.036433287,0.03279329,0.07157711,0.013934323,-0.018265333,-0.021523047,0.08177091,0.07899609,0.034503352,-0.047192074,-0.009730902,-0.03978859,-0.01887545,0.026114924,-0.0412391,-0.058615584,0.05662265,0.11477044,-0.0042194305,-0.066589974,0.060700096,0.010516719,0.035813604,-0.048228804,-0.046493184,-0.016881535,0.04142877,0.004803712,-0.027074069,-0.0946943,0.0025867615,0.010304575,-0.11681956,0.043217402,0.033951,-0.06343467,0.05099766,0.057134382,-0.002204989,-0.066116005,-0.05592969,-0.01737821,-0.0016077539,-2.8406473e-33,0.024055827,-0.08037372,-0.010260756,-0.09442398,-0.12811224,0.07113363,0.009490927,-0.11903996,0.0361565,-0.05375565,0.073245876,-0.0030512244,0.06312504,-0.06082255,0.014390387,0.014500233,0.05374428,0.03516958,0.0034501208,0.028896982,-0.025083605,0.058658734,-0.034932364,-0.029207861,0.04629987,0.050260805,-0.000925516,0.07439016,0.04569272,0.13850762,-0.10010637,-0.06504763,0.008922984,-0.036835335,-0.03238853,0.041639406,0.012408942,0.010515124,0.0026426206,-0.056775033,0.06966791,-0.0060905614,0.05858181,0.17504132,0.004077957,0.0757062,-0.10773233,-0.0028273433,-0.04685407,-0.021603948,0.094735175,0.05157713,-0.029040668,0.022982297,-0.014531012,0.027813429,-0.005609261,-0.07781057,-0.053138956,-0.033175543,-0.030272411,-0.10119881,0.03895907,-0.07207657,0.08252103,0.026136998,-0.05407236,0.094243675,0.0017893421,-0.029502545,0.002688071,-0.022289742,0.06485531,0.06124674,-0.02601499,-0.024328748,-0.040522363,-0.05734091,0.031448558,-0.03644084,-0.04361202,0.004255035,-0.0062392107,-0.047565404,-0.009141142,-0.027345914,-0.0058321115,0.14035448,0.03885266,0.0410433,-0.0259592,-0.056302004,0.039166916,0.06690178,0.033552445,-3.5877598e-08,-0.06868081,-0.064500764,0.004560888,0.00766462,0.007319922,0.07976353,-0.045178942,0.02595421,0.01568801,-0.008217092,0.002253684,0.10572773,0.021412443,0.0007099976,0.05876059,-0.014900867,-0.06625397,-0.008912369,-0.050314553,-0.118642464,-0.048592985,0.044297017,-0.12921979,-0.012939174,0.0028849114,0.021114176,0.006530242,0.074877106,0.0022742313,-0.016388185,-0.04023134,0.031036587,0.02767809,0.0038551413,-0.012310385,-0.027912982,-0.0056145308,-0.034597274,-0.021088772,0.0015354773,-0.025631497,0.0513248,-0.13908923,0.0401663,-0.056483787,0.04310858,0.04374492,0.01376422,0.01754376,0.06784247,0.08659486,-0.014185674,0.032133374,-0.0038951922,-0.086384654,0.012679108,0.028750746,-0.02030924,-0.064623944,0.0135297775,0.013188321,-0.04118944,0.13488004,-0.04929814 +1.21.98.1,"This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.",384,0.99999994,-0.06999642,-0.051646844,-0.1846295,0.052636273,0.00928703,0.0047300784,-0.06923235,0.0053947447,0.047499355,0.01931333,0.07040588,0.025365952,-0.0866375,0.05257985,-0.01644929,0.10148831,-0.13749078,0.0019178042,0.022050325,-0.009805077,0.06438485,0.027358457,-0.0062725055,-0.08735731,0.052363947,0.025861278,0.059879225,0.0064216196,-0.017101794,-0.010672214,0.11002372,-0.013037688,0.107656956,-0.015231434,0.014726653,0.07205282,-0.040231228,-0.059268206,0.0931492,0.024142122,-0.022044526,0.025659068,0.025006458,-0.018474279,0.03286198,-0.00095280405,0.011289721,0.020708503,0.0717666,0.060193628,-0.056388646,-0.025279807,-0.035694424,0.008431707,0.07538958,0.01129028,-0.0076562637,-0.036358677,-0.0050248383,0.021704998,0.081160866,0.0035246734,-0.06284522,-0.026321525,-0.0509119,-0.0058613927,0.013363591,-0.06072273,0.04412994,-0.031610243,0.018991876,-0.048846517,-0.021771412,0.03440652,-0.034591768,0.04085913,-0.020116176,-0.040790983,0.02215743,-0.0045672064,0.038955774,0.01986138,-0.0013102256,0.11664086,0.066939674,0.031602424,-0.0152699435,-0.015773626,0.0045599965,0.07088544,-0.022468159,-0.045338653,-0.027439164,-0.08347602,0.0172263,-0.011761332,-0.017997531,0.04089256,-0.06755882,-0.041452512,-0.02944044,0.03330784,-0.03502653,-0.1130242,-0.059404265,0.019366957,-0.0028555272,0.08922887,0.05294187,-0.0017979086,-0.064747564,0.06037819,0.009629709,-0.038617574,0.016718507,0.043511935,0.055172794,-0.038523484,-0.072243564,0.044076093,-0.007675203,0.061285857,0.029443156,0.090229504,0.010541213,0.01609084,-0.12536438,-5.7303917e-34,0.055089805,0.09376252,0.016254574,-0.05028454,-0.01002629,-0.037379537,-0.0500013,-0.08376638,-0.006511093,-0.01855699,-0.080310196,-0.051359504,0.017445534,-0.040374253,-0.046453573,-0.018878238,-0.012282664,-0.042147357,0.043966163,-0.04888229,-0.09007136,0.053532287,-0.09193408,-0.089848466,-0.006855028,0.025237385,0.034389377,0.0041466947,0.038189657,0.022356063,-0.068404004,-0.016853841,-0.13636656,-0.027323565,0.03150527,0.013737874,-0.06431532,-0.1153811,-0.026764778,0.059182122,0.05159049,0.01744108,0.009343252,0.06064139,0.04797307,0.00401531,-0.033864442,0.060191255,0.1172877,0.038172815,-0.008232712,0.003956397,0.10993371,0.006499698,-0.058871843,-0.05339259,0.016598709,0.07314588,0.012242195,0.09522443,-0.009827838,-0.06858565,-0.026558986,0.06847107,-0.05554183,-0.030424235,-0.053545702,-0.061783627,0.0040352973,0.116575494,-0.0138531625,-0.0054442077,0.06686697,-0.0049606203,-0.0015170627,-0.030546622,0.0013883015,0.06335172,0.022891656,-0.05822907,-0.06844775,-0.072489314,-0.011425335,-0.02432511,-0.03197179,-0.007138887,-0.022314763,-0.042301916,-0.051238786,-0.017673219,0.027382014,-0.07456715,-0.051459525,0.0594929,0.048499633,-1.135973e-33,-0.04388935,-0.08530513,-0.000968098,-0.08006844,-0.07511373,0.042341817,-0.0053434926,0.028437175,-0.002613952,-0.0022840367,0.050903596,-0.07239515,0.076244436,-0.058861185,0.018639524,0.0152741615,0.057118535,0.059617694,0.006957766,-0.026672855,0.016138982,0.08729667,0.059221186,-0.017004281,0.025583949,0.02819402,0.020396132,0.0569574,0.04361965,0.08685514,0.03021827,0.04223407,-0.07878513,-0.07550593,0.028611928,0.033686757,-0.010894083,-0.0025184497,0.016927054,-0.015924232,0.025182553,0.05339885,0.044806685,0.11666012,0.05054086,0.09478324,-0.0047876956,0.059164077,-0.021541605,-0.08468022,-0.015589374,-0.0044928095,0.00797967,0.038047507,0.010170578,0.029896315,0.020215409,-0.037622094,-0.026974373,-0.046872802,-0.09825467,-0.025246946,0.0440926,-0.029152853,0.0127715655,0.036245026,0.052610476,0.03314263,0.026352957,0.006054293,0.03342616,-0.016587239,-0.012548493,0.1015527,-0.047264267,0.017643489,-0.08622189,-0.032685287,0.028699351,0.00840379,0.011330729,-0.02042158,-0.026567934,-0.020421755,-0.023273032,-0.10129499,0.040577143,0.09596302,-0.014159782,0.017670479,-0.028554749,-0.0010850123,-0.104936615,0.0595527,-0.0016908945,-2.8610957e-08,0.035544112,-0.051232733,0.04012856,-0.050704677,0.067398235,0.030385643,-0.03362426,0.060393073,-0.00624694,0.011791327,-0.05747954,0.08215032,-0.027329708,0.002559686,-0.0064986343,0.026622484,-0.011383413,-0.009609644,-0.0036066642,-0.03793653,-0.01623113,-0.0019230099,-0.041473735,0.04537274,-0.07413352,0.015470903,0.052289817,0.044550158,0.019836573,-0.016430404,0.0324561,0.052365474,-0.046972785,0.010372312,-0.179261,0.04853623,0.035581212,-0.022483105,0.005824528,0.05074985,-0.006643051,-0.09490245,-0.0209171,0.056324396,-0.0070519596,0.016997863,0.017833661,0.03310326,-0.027583644,-0.044278547,0.004354815,-0.031222476,-0.04060967,-0.008393641,-0.13895068,-0.009097501,-0.059051502,-0.03678508,0.05299594,-0.055476982,-0.014448151,0.016582357,0.14386036,0.012942341 +2.1.1.308,"Requires cobalamin. The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. It is a radical S-adenosyl-L-methionine (SAM) enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. The enzyme uses two molecues of SAM for the reaction. One molecule forms a 5'-deoxyadenosyl radical, while the other is used to methylate the cobalamin cofactor. The 5'-deoxyadenosyl radical abstracts a hydrogen from the C2 position of cytidine 5'-{[(2-hydroxyethyl)phosphonoyl]phosphate} forming a free radical that reacts with the methyl group on methylcob(III)alamin at the opposite side from SAM and the [4Fe-4S] cluster with inversion of configuration to produce the (S)-isomer of the methylated product and cob(III)alamin. Both the [4Fe-4S] cluster and the cob(III)alamin need to be reduced by an unknown factor(s) before the enzyme could catalyse another cycle.",384,0.99999994,-0.071764626,-0.045155194,-0.13813047,-0.054606024,0.01393032,0.041479368,-0.11436263,0.01360208,0.025166614,0.0065510697,0.039232768,-0.022406492,0.038438518,0.046495967,0.014041849,0.035405613,-0.059173312,-0.0055340664,-0.054079864,-0.026921859,0.0059146835,0.026200347,-0.051091593,0.005140772,0.04604178,0.026458023,0.04525153,0.024837632,-0.06477995,-0.032424208,0.10310074,0.016320037,0.06434718,-0.029665116,0.013277515,0.11007885,-0.048933677,-0.045648713,0.15594591,0.054575827,-0.0710492,0.04795601,-0.0063578747,0.033639856,-0.026003642,-0.049784977,-0.013422563,0.05030776,0.056561083,-0.055832323,-0.068769656,-0.003140211,-0.063115835,0.0666439,0.06712512,0.030746626,-0.01956043,0.013272083,-0.0016273137,-0.017169133,0.06272302,-0.08006604,0.017152552,-0.023089448,-0.04851562,0.018197674,0.03752515,-0.076119386,0.06462852,-0.019099448,-0.04547652,-0.028165463,0.027568365,-0.0023361219,-0.047578104,0.00050069136,-0.01688344,-0.051449697,-0.012866997,-0.005205017,0.012718775,0.0020135483,0.02904958,0.02960622,0.07828464,-0.022445954,-0.041525405,-0.0087526245,0.030795205,0.059626833,0.058190778,-0.0076203337,-0.023444867,-0.106422596,-0.030744748,0.004657594,-0.025343327,0.04772488,-0.032824818,-0.0076705175,-0.0073452955,0.036156047,-0.060803007,-0.04596409,-0.012385841,-0.008740524,0.043193188,0.122172974,-0.020139175,0.017529126,0.0068486575,0.029423552,0.005431803,-0.03559447,-0.006916588,0.08999651,0.1475158,-0.052374605,-0.06768526,-0.006607466,0.065857746,0.015360912,0.066738814,-0.0076782983,-0.073212594,0.0410258,-0.11488259,5.1950712e-33,0.061370097,0.08438873,0.0040432694,-0.010817792,0.01580786,-0.027279519,-0.11936515,0.038180165,-0.00041706793,-0.056196265,-0.047199015,-0.009863603,0.072865896,-0.0637785,-0.07531523,-0.09321941,-0.02062234,0.012669747,0.033214238,0.009608978,0.034776233,0.015033735,-0.044520624,0.033381376,-0.02052417,0.06325858,0.028615111,0.028478911,0.060293853,0.027105344,-0.11153859,-0.04220492,-0.09515268,-0.02936215,0.049889654,-0.03438266,-0.108196005,-0.045149494,0.042400815,0.026386091,-0.026016265,-0.007157686,-0.027372077,0.042134568,0.08847249,-0.018692892,-0.05976942,0.08664054,0.04372213,0.089686096,0.037920415,-0.036027446,0.08055901,0.00044383743,-0.08160608,-0.009228681,0.036614563,0.0074614156,0.04048163,0.097886935,-0.0009818646,0.03584963,-0.03238795,0.022809334,0.029099451,0.008814413,-0.07880251,-0.03151573,-0.022567496,0.059116643,0.0036820448,0.02327325,0.08454927,0.072982185,0.0267292,0.0010018885,0.03833638,0.021889502,0.03810342,-0.009829403,-0.016338918,-0.022645442,-0.02056501,-0.039242435,-0.046081398,0.035310164,-0.009586479,-0.055079255,-0.022185046,0.031936374,-0.02800003,-0.05333324,-0.0044469074,-0.006547434,-0.0021522546,-5.4231307e-33,0.069301896,-0.071980365,0.04903436,-0.110244825,-0.022915376,0.0972923,0.03570018,-0.086130455,0.027656185,-0.049189143,0.07676627,-0.029399998,-0.0063084043,-0.029755363,-0.015106597,0.045743216,0.0054417998,0.084433556,-0.026089845,0.030468274,0.051744007,0.065373436,0.026144609,0.007102847,0.055097323,0.019594131,0.052445263,0.032922734,0.06395444,0.10170162,0.015190692,-0.055810858,-0.049436726,-0.07455775,-0.031235522,0.07172923,-0.10659102,-0.00456634,0.0047936034,-0.045464378,-0.0069250683,0.047021065,-0.0016141937,0.103672825,-0.0049834563,0.049361534,-0.07719596,0.029569687,0.020745523,-0.04912563,-0.010351148,0.02489121,-0.086063854,0.015481513,-0.03729175,0.012923879,0.05298037,0.020020964,-0.026460394,-0.03372401,-0.04894888,-0.07472647,0.02262107,-0.030731915,0.07132017,0.006622798,0.034264755,0.08331683,0.06741718,0.012454927,0.007606334,-0.0025952614,0.03135774,0.019811634,-0.0065012574,0.026798144,-0.09094892,-0.0108443955,-0.013403332,0.03390355,0.0014995807,-0.025708653,-0.011810345,-0.064658254,-0.026157076,-0.08891823,0.05357612,0.0829169,-0.00568063,-0.011089951,-0.07924128,0.017021565,-0.042933736,0.02871989,0.083091706,-5.7176795e-08,0.04016869,-0.04187714,0.05074835,-0.03345025,0.037238017,0.07533091,-0.067030646,-0.08639951,0.045820083,-0.04024815,-0.0116815595,0.06960356,-0.045638103,0.042523563,-0.078074545,-0.02478557,-0.118681744,-0.002288169,0.027003061,-0.01585677,-0.060227577,-0.014048326,-0.08200529,0.0076447953,0.026622271,-0.034413457,0.018931093,0.038726576,-0.0008830411,-0.00527476,0.07554215,0.0034729072,-0.050812807,-0.0038563113,-0.118975006,-0.024381654,-0.07260197,0.036669876,-0.034287978,0.10071071,-0.02195812,-0.07391599,-0.12532099,0.08846594,-0.047783297,0.00953617,0.025078602,0.045526527,-0.053613562,0.018906867,0.08393885,-0.02754047,-0.004460692,-0.0007559679,-0.10518576,0.032607317,-0.023971124,-0.04871551,-0.00798636,-0.030594232,-0.024075143,0.0019885993,0.12119323,-0.00635397 +2.1.1.309,"The enzyme, found in eukaryotes, is involved in pre-rRNA processing. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1].",384,0.99999994,-0.050642136,-0.0372945,-0.10088247,-0.04822652,-0.014327036,0.04647742,-0.08411021,0.008940188,0.03087352,0.027038857,0.011781109,-0.018563464,-0.06567019,0.06308859,-0.08072223,0.0069513307,-0.06267922,-0.014965436,0.023927132,-0.06955687,0.059125107,0.10295514,0.019789994,0.024216343,0.05110355,-0.05340212,0.0741905,-0.022285862,0.014517286,-0.028861193,-0.003135065,-0.030333491,0.13170528,-0.015382174,-0.023396976,0.07672567,-0.060270797,-0.08599519,0.04522671,0.036264528,0.050860118,0.0028752852,-0.032968815,0.023915282,-0.015752418,0.05989963,0.044206735,0.024049139,-0.026262095,-0.013381295,-0.029856497,-0.07630033,-0.06350192,0.016914492,0.07453029,0.07780761,-0.020819528,-0.0958883,-0.0018284932,-0.005967637,0.015147656,-0.070103176,0.008321086,-0.015084603,0.028299697,-0.03764331,0.06676117,-0.03026991,-0.0012663836,-0.06816957,-0.03858556,-0.012913791,-0.017362747,0.060200844,-0.04033486,0.030005388,0.023813497,-0.040707424,-0.014230823,0.0056768293,0.04251224,0.015629798,0.020207422,0.018354286,0.015623551,0.044177573,0.10769879,0.012557701,0.06729359,-0.022442672,0.027862113,-0.005903672,-0.014727643,-0.0022812705,-0.11839432,-0.028191237,0.026527923,0.08290785,0.06802282,-0.087941065,0.067906804,0.053597946,0.010875522,-0.003732184,-0.039171025,0.022014474,0.014336999,0.08517159,-0.008156135,0.033843547,0.026840055,0.045406293,0.0123368,0.007777598,-0.029139409,0.022533102,0.039861716,-0.009285795,0.02414252,0.00786512,-0.052020676,0.027308712,0.055408932,0.02415793,-0.07475081,0.023403736,-0.15993202,-1.6848447e-33,0.01830572,-0.0015967017,-0.025941528,-0.03061321,0.003186202,-0.013849571,-0.046443462,-0.004641289,-0.014717891,-0.051711503,-0.07341899,-0.009195635,0.0017292423,0.042221144,-0.0661314,-0.009462198,0.013935526,-0.014081567,-0.030559894,0.02094295,-0.04854003,0.031471804,-0.03953475,0.0014830151,0.022845544,0.07082309,0.000698559,-0.0629037,0.049200214,-0.034155134,-0.030970192,-0.0922781,-0.11186584,0.04630736,0.05883974,0.019929968,0.061714362,-0.044491783,-0.023095537,0.050611805,0.016979335,0.0014324299,0.0066256654,-0.020379461,-0.009289317,-0.072133094,-0.082539044,0.1302174,0.05566938,0.066249736,0.0030573276,-0.012289694,0.11028529,-0.030391607,-0.07241198,0.0219514,-0.022211011,0.022662278,0.046118155,0.034928642,-0.042666897,0.0142353615,-0.049284168,0.09964411,0.013271244,0.005099209,-0.030356305,-0.079360366,0.039325874,0.08554326,-0.09748957,-0.011352483,0.05408068,0.004453609,0.058277324,-0.009487888,-0.113230735,-0.044463295,-0.027693912,0.06405271,-0.06952681,-0.017783273,-0.023783913,-0.029558126,-0.037240934,0.0093952175,0.035643864,-0.048138145,-0.010827713,-0.025205594,0.07800756,-0.023194255,-0.026988566,0.056314096,0.03600279,-1.0118964e-33,0.13782102,-0.085579745,0.05094689,-0.037940998,-0.04837972,0.046378206,0.030275187,-0.099809356,-0.0074916226,-0.067805074,0.04156605,-0.021925395,0.03232439,-0.0191204,0.07999424,-0.0081844935,-0.00026672063,0.051997714,-0.021585373,-0.007167281,-0.0070113163,0.0740407,-0.060408413,-0.008966968,0.036980323,-0.0029932149,0.074137606,0.070050865,0.034156647,-0.013628241,-0.06574498,-0.011128896,0.031610984,-0.0071376017,-0.07980932,0.072690725,-0.0012305635,-0.02621205,0.02235712,0.033619486,0.05694971,0.07568082,-0.08457319,0.09426807,-0.08083408,0.05705046,-0.04580974,0.092444636,0.024209812,-0.07308679,0.006401253,0.0115655,0.013626442,-0.023430165,0.07249922,0.01829248,-0.02133533,-0.0028004432,0.03766235,0.0029469025,-0.004373471,-0.06516651,0.050914228,-0.00046671287,0.013133455,0.055886306,-0.05498528,-0.00023593577,0.0067648315,-0.061224975,0.0851473,0.06081942,-0.0174224,0.006269923,-0.06016308,-0.040770624,-0.099163786,-0.049135197,0.0024076959,-0.05883377,-0.0059967875,-0.017624356,-0.001149299,0.021013545,-0.018316908,-0.084404044,0.07686042,0.013359921,-0.028071955,0.02400681,-0.007053118,-0.02615875,-0.028208194,0.06052565,0.025985952,-3.064067e-08,0.060815044,-0.054370463,0.03917491,-0.07497423,0.07364855,0.07893762,0.027236683,0.058155414,0.015011012,0.040001336,-0.05880325,0.042785153,0.0073980633,0.028588811,0.07426959,0.05575557,-0.014898347,0.032863464,-0.013891132,0.007138503,-0.04414965,0.011953336,-0.07723231,0.011627528,0.0037084697,-0.053671002,0.043706335,0.11269559,-0.029851677,-0.07692434,-0.029794326,0.009733869,0.05520422,-0.056038138,-0.07847058,0.08509397,0.009986997,-0.013281575,-0.027021805,-0.030761713,-0.030474111,-0.07454527,-0.065431274,-0.008418121,-0.09410533,0.010730876,-0.03344494,-0.0046155155,-0.024833571,-0.047442038,0.040334273,0.042505175,0.042287227,-0.032920063,-0.13456172,0.02810011,-0.036706366,-0.102747686,-0.033421822,-0.011688157,0.03943889,0.033389762,0.20517573,-0.12013976 +2.1.1.310,"The enzyme, found in eukaryotes, is specific for cytosine2870 of the 25S ribosomal RNA. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1].",384,1.0,-0.0017616013,-0.010826716,-0.046723045,-0.074295044,-0.017728169,0.015544585,-0.05375656,0.03888018,0.003164106,0.022571998,0.0022994992,-0.01812475,-0.041495945,0.059799474,-0.11257434,0.008397328,-0.044275437,-0.037592776,0.029375058,-0.062323675,0.030756285,0.112601444,0.025113473,0.0070133605,-0.0030433382,-0.03476106,0.04599136,-0.0072908825,-0.04901667,-0.052111678,-0.004449348,0.0027152793,0.10274811,0.018850725,0.0029879238,0.006100697,-0.058593646,-0.07357833,0.07647443,0.0304746,0.0371087,0.009638216,0.03489549,0.017824652,0.0020266522,0.08703425,0.0035948732,0.060952038,0.047973305,0.037734367,0.0009813901,-0.059205655,-0.049181964,-0.0147146415,0.022581823,0.033161733,-0.00744049,-0.047040552,0.01756322,0.03495642,0.026314951,-0.06920959,-0.008827766,-0.0053084837,0.04113734,-0.043388676,0.057435285,-0.030412046,-0.05730992,-0.047100883,0.021222467,-0.04913066,-0.022444751,0.08890313,-0.019475572,0.026365707,0.05797456,-0.056969587,-0.02949648,-0.045434024,-0.03319637,-0.029303584,0.055832632,-0.002019386,-0.017136823,0.020481013,0.041513745,0.10219577,0.06961838,0.021729806,0.011983833,0.026272636,0.0020569013,-0.0050864527,-0.040277936,0.041199617,0.013755631,0.1781133,0.018920235,-0.06635204,0.066114604,0.07477939,0.032847535,-0.020892115,-0.015184349,0.09336754,0.073940106,0.026453396,-0.016472967,-0.012707372,-0.034178417,0.030906381,0.0023996364,-0.061630145,0.057197426,-0.029028388,0.07137768,0.01834645,0.030307109,0.027067332,0.011213893,-0.016800469,0.046712715,0.042476453,-0.10253581,0.08132897,-0.17629014,1.2852821e-34,-0.021046251,-0.022122787,0.026325736,0.036161352,-0.011237494,-0.0018074338,0.008137241,0.003917479,-0.07289523,-0.08245565,-0.15954554,-0.076180235,0.054309383,-0.038187537,-0.06341631,-0.004457336,0.021073861,-0.026755732,-0.041650236,0.0150665995,0.018613402,0.015190847,-0.061876506,-0.003711425,0.038029127,0.021082355,0.020998525,-0.043512736,0.06857995,-0.03056194,-0.06257202,-0.046898372,-0.05174774,0.023802772,0.071755365,-0.015531839,0.014794763,0.021817543,0.018561747,0.042462837,0.02135423,0.0013049303,0.018127456,-0.03276341,0.050050188,-0.011432258,-0.037276533,0.039341465,-0.009384759,0.058791094,0.052930064,-0.010342617,0.057291824,-0.023471368,-0.003773527,0.062178228,-0.02361218,0.041623004,0.03811382,0.030535305,-0.027095325,0.01225481,-0.010330301,0.09134808,0.006920315,0.029360404,-0.07085329,-0.09212323,-0.053779673,0.1290021,-0.08169113,-0.006894848,0.1140702,-0.014066854,0.008313922,-0.06998553,-0.08534623,-0.072986946,-0.061471332,0.08581526,-0.012682936,-0.03542238,-0.07254807,-0.013340465,-0.011375254,0.015055309,0.028720375,-0.022032969,-0.025180124,0.013169732,0.049138665,-0.12590063,-0.06408909,0.027334752,0.020758219,-2.2326607e-33,0.093655914,-0.021457799,0.054367345,-0.03496873,-0.05518261,0.01572734,0.0059109763,-0.06342268,-0.017944757,-0.017204938,0.08164016,0.002669419,0.0313533,-0.047047272,-0.017220581,0.024801359,-0.04846262,0.08941085,-0.03743207,0.03415051,-0.03736066,0.07062674,-0.043145154,0.03612179,0.037946366,-0.003403816,0.01652497,0.075944446,0.030751657,-0.05857149,-0.12588811,-0.008668653,0.043027442,-0.017506804,-0.037174165,0.035789464,-0.0004976257,-0.08549649,0.06065269,0.00300682,-0.04822679,0.10806916,-0.033080414,0.099623695,-0.044525523,0.09712329,0.0037567255,0.014399936,-0.004135257,-0.06906032,0.024274055,-0.026566297,0.013165205,0.052703753,0.042188656,-0.006420209,-0.030142913,0.10519405,0.031213949,0.007906401,-0.022886252,-0.051980585,0.046118915,0.011037988,0.05361401,0.036200855,-0.1105301,0.06380192,-0.0420473,-0.0535081,-0.004678565,-0.015596949,-0.05261775,0.027819555,-0.005883465,-0.06801847,-0.053280752,-0.045956735,-0.054837044,-0.023275454,0.021812996,-0.03234744,0.026997788,0.023104204,0.044743687,-0.12524505,0.10087927,0.07920972,-0.022772945,0.025171291,-0.013822505,-0.031162726,-0.02701791,0.05039104,0.031118391,-3.1099184e-08,0.032541927,0.021227244,-0.023404894,-0.09653212,0.026109042,0.06244622,0.003243188,0.03854331,0.021976834,0.013040514,0.020330943,0.00037561133,-0.01647613,0.06427446,0.06876069,-0.023396453,-0.11678423,-0.0071954867,0.03217381,0.08950233,0.020636084,0.05840442,-0.08279248,0.048862215,-0.07053567,-0.018313708,0.023275165,0.051890813,-0.018483136,-0.0979266,-0.061203886,-0.020455353,0.005784695,-0.049882356,-0.08905568,0.07373339,-0.006611808,-0.02028282,0.0031989452,0.0074160183,0.032514356,-0.110964596,-0.077535555,-0.028867248,-0.07633857,-0.048651423,0.0031716144,0.0144400345,-0.00021238187,-0.0349761,0.0049977237,0.06269078,0.021253588,-0.061374012,-0.03903912,-0.004346133,-0.058720585,-0.09243373,0.008009502,-0.048337646,0.014429096,-0.0037496798,0.14831972,-0.097228214 +2.1.1.311,"The enzyme, found in eukaryotes, is specific for 25S cytosine2278. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1].",384,1.0,-0.038317114,-0.035201054,-0.023979438,-0.07618191,0.0057270955,-0.011791236,-0.033020698,0.044728115,0.027153203,0.016984997,0.012808014,-0.028223597,-0.056128148,0.042934444,-0.11255576,-0.0036390235,-0.046443038,-0.02696468,0.015392081,-0.09315562,0.059631437,0.063404955,0.009554746,0.02988733,-0.006705164,-0.03166679,0.016696725,-0.007585424,-0.043125857,-0.05347708,-0.010232727,0.018948544,0.08573639,-0.0075634434,-0.016437666,-0.005010316,-0.087380536,-0.07929064,0.07442333,-0.00578026,0.06462293,0.009414933,0.024585314,0.04667684,-0.00021497678,0.05038276,-0.019993488,0.02399051,0.012239496,0.03667311,-0.020751107,-0.057405304,-0.030755414,0.022150343,-0.0155469775,-0.033750623,-0.046778664,0.009957708,0.006250604,0.046571318,0.03212334,-0.049241673,0.0073221084,-0.02414974,0.017613307,-0.038721688,0.07035221,-0.077525795,-0.07491311,-0.038522158,-0.0096583795,-0.032699585,0.017317563,0.053381246,-0.01789504,0.055714514,0.046540685,-0.066675834,-0.019182956,-0.037442327,0.016432157,-0.013960499,0.06769682,0.04106022,0.00630764,-0.07392711,0.0802424,0.06827206,0.09659374,0.026491014,-0.016494581,0.01948751,-0.057615045,0.0082574375,-0.06100163,0.043106396,0.008443969,0.1540842,0.044580106,-0.042041384,0.058406264,0.08074502,0.046339203,-0.033528697,-0.03193973,0.06419998,0.031810503,0.043658767,0.0060017537,-0.015267379,-0.014168819,0.033335056,0.009873576,-0.031416703,0.06446962,-0.008526583,0.018824559,0.051376376,0.055004008,0.008304896,0.0030785543,-0.0028830376,0.028860109,0.017891875,-0.13159253,0.09753162,-0.20964733,8.276665e-34,-0.033677578,0.011353117,0.019086836,0.057454217,-0.03189187,-0.01579995,-0.0002528169,0.027515974,-0.10497182,-0.03210583,-0.12406119,-0.07863776,0.0628596,-0.012706036,-0.04514157,0.01093494,0.058846217,-0.017953174,0.0018393826,-0.014197184,0.02225097,0.001127663,-0.117411524,-0.06955108,0.066640876,0.039018225,-0.005544284,-0.006609904,0.053093355,-0.0118309045,-0.046927102,-0.06802773,-0.036178377,0.0041090967,0.10076763,-0.025276601,0.044638332,0.004412647,0.011196926,-0.00786752,0.054421306,0.04263736,0.02864883,-0.045082938,0.06304801,-0.011114344,-0.045398515,0.04857582,0.04573147,0.059507858,-0.0136297345,0.013554933,0.062229622,-0.01169468,-0.013844356,0.058854535,-0.01764205,0.044116616,0.030475706,0.0409209,-0.0059628715,0.05296623,-0.009739056,0.04097487,0.039670616,0.04278816,-0.058813825,-0.046430442,-0.049906418,0.1378739,-0.09159034,0.032691587,0.063707836,-0.021110969,0.054125283,-0.10396535,-0.026239138,-0.044714116,-0.024782771,0.07334742,-0.013372041,-0.018810807,-0.06545279,-0.01801892,-0.02734332,0.013969385,-0.02493696,0.04388839,-0.026466293,0.021201698,0.07596455,-0.17923374,-0.019244187,0.047548816,-0.046837073,-2.7443965e-33,0.07410035,-0.009572553,0.05735606,-0.06350692,-0.011060402,-0.01166242,0.040777225,0.0071750036,0.0010977872,-0.0032612989,0.12266998,-0.017932871,0.017313551,-0.005006504,-0.0023750435,0.039430853,-0.06682826,0.068291456,-0.029833285,0.015598332,-0.047987822,0.062436193,-0.0062505202,0.05562219,0.05253783,0.022520196,0.042517636,0.0643946,0.033502284,-0.027177012,-0.15177067,-0.031725954,0.030587858,-0.011446404,-0.049346898,-0.0014820945,-0.012226284,-0.08595323,0.012225324,0.011472419,-0.017694201,0.09342205,0.0054605105,0.124213554,-0.046552673,0.08860058,0.006214115,0.0487121,0.0121703865,-0.05864776,-0.024986925,-0.0070338617,-0.013426931,0.0111023,0.05683078,0.010482781,-0.042740498,0.0917269,-0.011650022,-0.007971574,0.010438878,-0.048200484,0.0461515,0.02547521,0.05419988,0.06887565,-0.117718905,0.04221098,-0.038473163,-0.032534428,0.017803406,0.01209646,-0.07135962,0.0069176424,-0.051888898,-0.071048535,-0.025016824,-0.015269835,0.005974531,-0.031550616,0.074432835,0.0014393165,0.02256208,-0.02201456,0.017895529,-0.121290915,0.08801673,0.08133436,-0.01943443,0.023108704,-0.016285297,-0.02356702,-0.035956644,0.02665116,0.030339802,-3.102537e-08,0.078158036,-0.001041399,-0.013250967,-0.08051708,0.030712051,0.09689512,-0.022044409,0.027643768,0.024852538,0.042061385,-0.021640304,0.042714633,-0.0061896844,0.08725417,0.0467531,-0.05558689,-0.08071568,0.017331282,0.02215889,0.059050918,0.008584005,0.028113648,-0.06622173,0.037236664,-0.018159224,-0.056306973,0.016892573,0.068787135,-0.06151981,-0.070239365,-0.0672487,-0.016976772,-0.049438898,-0.02040565,-0.0561411,0.07516236,-0.09682056,-0.039840862,-0.025779422,-0.025397481,0.02960792,-0.106184155,-0.063723914,-0.0021687231,-0.044190213,-0.04484636,-0.010309806,-0.02240486,-0.010678504,-0.042551123,-0.037355606,-0.009791523,0.03003597,-0.035734527,-0.03865202,-0.01650314,-0.035763633,-0.08452302,-0.024207536,-0.050249267,0.030833002,0.0047011077,0.14075148,-0.094615355 +2.1.1.312,"The enzyme, described from the yeast Saccharomyces cerevisiae, is involved in ribosome biogenesis.",384,1.0,0.032467425,-0.027570436,-0.11020644,-0.040570565,0.03777015,0.012721169,-0.0953398,0.014920026,0.054679073,0.012058784,0.013169665,0.002431173,-0.03535716,0.054777544,-0.09872815,0.02568326,-0.06553409,0.0029253673,0.026861217,-0.026797922,0.072424725,0.09361111,0.044903725,0.021766134,0.01418464,-0.047724467,0.06495474,-0.0005118937,-0.026233053,-0.053969722,0.0089707365,0.014895046,0.09848788,0.0002985878,-0.03857739,0.09977787,0.038563784,-0.026392112,0.046476953,-0.0057632136,-0.0051416773,-0.03504406,-0.044875953,0.022434082,0.013141668,0.052079722,0.022348134,0.07128452,0.051336788,0.018017326,-0.068302505,-0.06305343,-0.07109199,-0.08975857,0.052729372,0.051200423,0.019088088,-0.07847895,0.0120120235,-0.008075648,-0.0026824414,-0.058819335,-0.009328272,0.050399043,0.056537356,-0.06733944,0.04069211,0.057018723,-0.019164983,-0.023966739,-0.010311013,-0.05239716,-0.08402812,0.050038327,-0.00495507,0.010605221,0.041155163,0.0018897263,0.047054693,-0.017682485,0.005858643,-0.002358598,0.047803868,0.01968064,0.00027425928,0.07244796,0.058500767,0.042924546,0.05427661,0.0016278067,-0.024709089,0.0027942162,0.013872261,-0.00576071,-0.039452147,-0.002118804,-0.00742434,0.039162938,0.028374644,-0.09256362,0.046433944,0.033315334,0.04768419,-0.01706765,0.024795718,0.04532993,0.022093577,0.07904975,-0.02227971,0.020616474,0.0458327,0.03047461,-0.009748011,-0.019959562,0.0349162,0.08903822,0.069908194,-0.04451117,0.0077211144,0.021451429,-0.021680506,0.060043335,-0.018311253,0.057468638,-0.13423043,0.019815365,-0.098329596,-1.1450639e-33,0.021572078,-0.005450251,-0.034933705,0.04710983,-0.023783684,0.012034566,-0.059147574,-0.034204166,-0.034780193,-0.045701813,-0.13099453,-0.07022136,0.037478503,0.007269233,0.022361599,-0.049321506,-0.023814768,0.0069650905,-0.017005788,-0.008098197,-0.054545004,0.043539517,-0.03744469,0.022175506,0.048305262,0.024646487,0.039622378,-0.046386532,0.043097798,-0.06987645,-0.01649907,-0.049321268,-0.082558475,0.05056437,0.03411799,0.049159765,0.006557912,-0.0032255258,0.03812484,0.05768758,0.025894452,-0.027172457,-0.010763562,-0.059038654,0.00730759,-0.015569362,-0.03309483,0.034276202,-0.010819454,0.052646317,0.051213484,-0.02191357,0.10154041,-0.040400106,-0.053307123,0.04733356,-0.06832979,-0.005143932,0.029448023,-0.006083866,-0.06567624,0.0015754945,0.00042604312,0.15244189,0.0074723195,0.015371857,-0.049459003,-0.09274009,-0.014157702,0.08521033,-0.043094166,-0.00043574462,0.07916199,-0.037635162,-0.023594063,-0.01663142,-0.13850929,-0.04149711,-0.045143276,0.08744757,-0.014849141,-0.06471511,-0.08514364,-0.04561624,-0.044693906,0.048327338,0.049119532,-0.05658884,-0.03186991,-0.038207103,0.033271465,-0.047340743,-0.038065936,0.052259956,0.044495273,-2.2642212e-33,0.11737766,-0.09245554,0.06881228,-0.047599416,-0.10240256,0.062408183,-0.029997213,-0.09468051,-0.04862916,-0.04828563,-0.020305533,-0.016082982,0.037662294,-0.08676675,-0.032403927,-0.028477384,-0.016768219,0.030624958,-0.033961013,0.03170516,-0.005248792,0.100558944,-0.044912398,-0.025141062,0.0056516766,0.0010003834,0.029009635,0.089221805,0.024829298,-0.009298455,-0.03960229,-0.0006295213,0.02175545,-0.025259353,-0.045960173,0.107858054,-0.00017149882,-0.02556214,0.05648495,-0.019270655,-0.040218573,0.12876621,-0.080460854,0.07373546,-0.015441469,0.07340108,0.024982171,0.011008443,-0.019451901,-0.09439415,0.038355358,-0.008249734,0.047453426,0.01842443,-0.0021642623,-0.008632505,-0.0046144794,0.03966441,-0.02630596,-0.026939055,-0.06297552,-0.050158232,0.04990378,-0.014301573,0.040927432,0.05877905,-0.07615637,-0.011958155,-0.012522449,-0.0037010221,0.058228146,0.05347603,-0.032128036,0.06759596,0.009175687,-0.03468857,-0.086992465,-0.04326626,-0.058644738,-0.036203,-0.04567902,-0.022195768,0.04989292,0.0076793632,0.02394036,-0.14006416,0.011619887,0.063117795,-0.030800102,0.045306604,-0.0058391043,-0.019042598,-0.05272705,0.046243172,0.046627197,-2.457589e-08,0.066725664,0.053708967,0.017730532,-0.10887318,0.017408527,0.04029402,0.0675533,0.03155014,0.017540216,0.006200531,-0.09730075,0.06474998,-0.021249408,0.014948967,0.04532964,0.036359582,-0.07606809,-0.019347062,0.019450985,-0.007298361,0.029448945,0.022319634,-0.07962876,0.08159308,-0.054509267,-0.028605511,0.03645257,0.02318016,0.06168489,-0.06772798,-0.027535671,0.079713516,0.054988053,-0.08659356,-0.07684788,0.048594005,-0.0023229306,-0.02689304,0.02018973,0.029970303,0.019880427,-0.050227955,-0.04695539,-0.040626016,-0.095937766,-0.018347593,0.031794995,0.007747896,0.029650878,-0.017728154,0.07107572,0.107370734,0.0039375513,-0.06780714,-0.10291625,0.045835227,-0.055583566,-0.09287026,0.046975512,-0.03210162,0.02030459,-0.024848824,0.15462615,-0.11428766 +2.1.1.313,"The enzyme, described from the yeast Saccharomyces cerevisiae, is involved in ribosome biogenesis.",384,1.0,0.032467425,-0.027570436,-0.11020644,-0.040570565,0.03777015,0.012721169,-0.0953398,0.014920026,0.054679073,0.012058784,0.013169665,0.002431173,-0.03535716,0.054777544,-0.09872815,0.02568326,-0.06553409,0.0029253673,0.026861217,-0.026797922,0.072424725,0.09361111,0.044903725,0.021766134,0.01418464,-0.047724467,0.06495474,-0.0005118937,-0.026233053,-0.053969722,0.0089707365,0.014895046,0.09848788,0.0002985878,-0.03857739,0.09977787,0.038563784,-0.026392112,0.046476953,-0.0057632136,-0.0051416773,-0.03504406,-0.044875953,0.022434082,0.013141668,0.052079722,0.022348134,0.07128452,0.051336788,0.018017326,-0.068302505,-0.06305343,-0.07109199,-0.08975857,0.052729372,0.051200423,0.019088088,-0.07847895,0.0120120235,-0.008075648,-0.0026824414,-0.058819335,-0.009328272,0.050399043,0.056537356,-0.06733944,0.04069211,0.057018723,-0.019164983,-0.023966739,-0.010311013,-0.05239716,-0.08402812,0.050038327,-0.00495507,0.010605221,0.041155163,0.0018897263,0.047054693,-0.017682485,0.005858643,-0.002358598,0.047803868,0.01968064,0.00027425928,0.07244796,0.058500767,0.042924546,0.05427661,0.0016278067,-0.024709089,0.0027942162,0.013872261,-0.00576071,-0.039452147,-0.002118804,-0.00742434,0.039162938,0.028374644,-0.09256362,0.046433944,0.033315334,0.04768419,-0.01706765,0.024795718,0.04532993,0.022093577,0.07904975,-0.02227971,0.020616474,0.0458327,0.03047461,-0.009748011,-0.019959562,0.0349162,0.08903822,0.069908194,-0.04451117,0.0077211144,0.021451429,-0.021680506,0.060043335,-0.018311253,0.057468638,-0.13423043,0.019815365,-0.098329596,-1.1450639e-33,0.021572078,-0.005450251,-0.034933705,0.04710983,-0.023783684,0.012034566,-0.059147574,-0.034204166,-0.034780193,-0.045701813,-0.13099453,-0.07022136,0.037478503,0.007269233,0.022361599,-0.049321506,-0.023814768,0.0069650905,-0.017005788,-0.008098197,-0.054545004,0.043539517,-0.03744469,0.022175506,0.048305262,0.024646487,0.039622378,-0.046386532,0.043097798,-0.06987645,-0.01649907,-0.049321268,-0.082558475,0.05056437,0.03411799,0.049159765,0.006557912,-0.0032255258,0.03812484,0.05768758,0.025894452,-0.027172457,-0.010763562,-0.059038654,0.00730759,-0.015569362,-0.03309483,0.034276202,-0.010819454,0.052646317,0.051213484,-0.02191357,0.10154041,-0.040400106,-0.053307123,0.04733356,-0.06832979,-0.005143932,0.029448023,-0.006083866,-0.06567624,0.0015754945,0.00042604312,0.15244189,0.0074723195,0.015371857,-0.049459003,-0.09274009,-0.014157702,0.08521033,-0.043094166,-0.00043574462,0.07916199,-0.037635162,-0.023594063,-0.01663142,-0.13850929,-0.04149711,-0.045143276,0.08744757,-0.014849141,-0.06471511,-0.08514364,-0.04561624,-0.044693906,0.048327338,0.049119532,-0.05658884,-0.03186991,-0.038207103,0.033271465,-0.047340743,-0.038065936,0.052259956,0.044495273,-2.2642212e-33,0.11737766,-0.09245554,0.06881228,-0.047599416,-0.10240256,0.062408183,-0.029997213,-0.09468051,-0.04862916,-0.04828563,-0.020305533,-0.016082982,0.037662294,-0.08676675,-0.032403927,-0.028477384,-0.016768219,0.030624958,-0.033961013,0.03170516,-0.005248792,0.100558944,-0.044912398,-0.025141062,0.0056516766,0.0010003834,0.029009635,0.089221805,0.024829298,-0.009298455,-0.03960229,-0.0006295213,0.02175545,-0.025259353,-0.045960173,0.107858054,-0.00017149882,-0.02556214,0.05648495,-0.019270655,-0.040218573,0.12876621,-0.080460854,0.07373546,-0.015441469,0.07340108,0.024982171,0.011008443,-0.019451901,-0.09439415,0.038355358,-0.008249734,0.047453426,0.01842443,-0.0021642623,-0.008632505,-0.0046144794,0.03966441,-0.02630596,-0.026939055,-0.06297552,-0.050158232,0.04990378,-0.014301573,0.040927432,0.05877905,-0.07615637,-0.011958155,-0.012522449,-0.0037010221,0.058228146,0.05347603,-0.032128036,0.06759596,0.009175687,-0.03468857,-0.086992465,-0.04326626,-0.058644738,-0.036203,-0.04567902,-0.022195768,0.04989292,0.0076793632,0.02394036,-0.14006416,0.011619887,0.063117795,-0.030800102,0.045306604,-0.0058391043,-0.019042598,-0.05272705,0.046243172,0.046627197,-2.457589e-08,0.066725664,0.053708967,0.017730532,-0.10887318,0.017408527,0.04029402,0.0675533,0.03155014,0.017540216,0.006200531,-0.09730075,0.06474998,-0.021249408,0.014948967,0.04532964,0.036359582,-0.07606809,-0.019347062,0.019450985,-0.007298361,0.029448945,0.022319634,-0.07962876,0.08159308,-0.054509267,-0.028605511,0.03645257,0.02318016,0.06168489,-0.06772798,-0.027535671,0.079713516,0.054988053,-0.08659356,-0.07684788,0.048594005,-0.0023229306,-0.02689304,0.02018973,0.029970303,0.019880427,-0.050227955,-0.04695539,-0.040626016,-0.095937766,-0.018347593,0.031794995,0.007747896,0.029650878,-0.017728154,0.07107572,0.107370734,0.0039375513,-0.06780714,-0.10291625,0.045835227,-0.055583566,-0.09287026,0.046975512,-0.03210162,0.02030459,-0.024848824,0.15462615,-0.11428766 +2.2.1.12,"Requires thiamine diphosphate. The enzyme, characterized from the bacterium Serratia marcescens, participates in the biosynthesis of the antibiotic prodigiosin. The enzyme decarboxylates pyruvate, followed by attack of the resulting two-carbon fragment on (E)-oct-2-enal, resulting in a Stetter reaction. In vitro the enzyme can act on a number of alpha,beta-unsaturated carbonyl compounds, including aldehydes and ketones, and can catalyse both 1-2 and 1-4 carboligations depending on the substrate.",384,0.99999994,-0.053657077,0.028631622,-0.1012102,-0.035609856,-0.007978739,0.042232648,-0.0963365,0.06969497,0.018178346,0.056417923,-0.017106865,-0.07593539,-0.053877473,0.027441913,0.0022254658,0.012325036,-0.07214715,-0.01410317,0.061398927,-0.02116226,0.06305441,0.048230093,-0.017585233,-0.010538356,0.012856084,0.014592001,0.09042549,0.0032453102,0.023970483,-0.08223914,0.006867783,-0.03182226,0.07858926,-0.071671665,0.052664615,0.09740702,-0.03767407,-0.024304349,0.060484268,0.051559743,0.038396996,0.046674207,-0.06102388,-0.0004742711,-0.004554716,-0.050983265,0.058556322,0.113233745,-0.0003835064,-0.024301369,-0.06244297,0.009898503,-0.040166352,0.02231617,0.0027543576,-0.019278279,0.025035644,-0.03282812,-0.05276086,0.0012232303,0.062940866,-0.04843002,-0.008330653,-0.026918245,-0.006253892,-0.06967188,0.031787727,-0.082740486,0.033605363,0.0031566562,-0.095472835,-0.029241247,0.037590582,0.039909665,0.003782417,-0.002091967,-0.029328264,-0.06264746,-0.033396136,-0.010020858,0.018169105,-0.05930675,-0.03576942,0.0630979,0.10115043,-0.00630224,0.04398965,0.0007160226,0.05795631,0.06664347,0.04854408,-0.023528961,-0.0021843323,0.0016883616,-0.11121261,0.010557194,0.033933032,-0.017484581,0.01629295,-0.03565032,-0.015724448,0.025632873,-0.04075729,-0.05361518,-0.029496849,0.027243234,0.026228463,0.07847055,0.0076732486,0.036024302,0.009034209,0.031808835,0.0076136515,0.016961053,-0.072045006,0.0917233,0.05062227,-0.056631718,-0.062193953,-0.015636282,0.005283705,0.011411062,0.03865615,0.029826708,-0.06289295,0.030400887,-0.10231029,2.4920484e-33,0.060100365,0.05496557,-0.019563023,-0.02946512,-0.007791572,-0.006552227,-0.12758979,0.028073002,-0.041776363,-0.054353517,-0.019473823,-0.1156526,0.07482921,0.06974519,0.057496887,-0.07085828,-0.02278579,0.029080186,0.079146914,-0.039098855,-0.00897139,-0.006857426,-0.071889766,0.043197073,0.015268824,0.08724719,0.079576895,0.09619103,0.024764126,-0.0054174415,0.043716304,-0.068436034,-0.066235326,0.0027780875,0.14296758,0.0036185123,-0.011065163,-0.024057642,-0.029314827,0.048670195,0.013154065,0.020013738,-0.024251003,-0.024954036,0.025324628,-0.13881297,-0.024297463,0.08628906,0.054818526,0.020344283,0.061859604,-0.0022914298,0.104792796,0.008225643,-0.048163954,0.05716252,0.014319215,-0.008694864,0.054967787,-0.018953081,0.0053352644,-0.0070656645,-0.031978153,0.029584046,-0.0489871,0.036169227,-0.10914353,-0.04436064,-0.028112538,0.039462358,-0.08264593,0.03273577,0.030511735,-0.0054649706,-0.056830738,0.018307684,-0.08376068,0.033882953,0.05722429,-0.020769734,0.039730188,-0.01739479,-0.007328639,-0.053303264,-0.055558007,-0.035238277,-0.021662228,-0.014125155,-0.0014631241,0.034290526,0.03432565,-0.010464201,-0.038186453,0.02430321,0.03904863,-3.6330868e-33,0.08396804,-0.08814445,0.06681628,-0.04719692,-0.021145666,0.043059953,0.012425458,-0.07252643,-0.0092113055,-0.0784276,0.014708139,-0.029485378,0.039265506,-0.026320431,-0.008259997,0.05722692,0.034340646,0.085189305,-0.008134202,-0.07461893,-0.008050951,0.09534317,0.009149872,-0.028499031,-0.008415865,0.03367966,0.01638703,0.04455243,0.01620749,0.07486939,0.021905579,-0.007125589,-0.04681424,-0.027796062,-0.08793292,0.10874405,-0.047375143,0.015587341,0.03424363,0.06057903,-0.021571876,0.011157709,0.014763307,0.08124383,0.07007198,0.022665177,0.017850673,-0.017936528,-0.016864331,-0.03990442,0.07410174,0.012284617,-0.009249963,0.0035130624,0.04899885,-0.014388926,-0.03897796,-0.048181765,0.05857011,-0.044090662,-0.0071468083,-0.057413355,0.035617474,-0.04433052,0.025644964,-0.025374334,-0.024539573,0.043326553,0.08837196,-0.04934934,0.12063456,0.07060343,-0.050339773,0.0403131,-0.06894464,0.023062773,-0.09876678,-0.047964144,-0.033136405,0.012697296,-0.042395163,-0.036852922,-0.00097319676,-0.025160424,-0.07180868,-0.072626226,0.011412034,0.035581183,-0.04152195,0.040685154,-0.080886625,-0.019408999,-0.0016742385,0.093191914,0.12277054,-4.491001e-08,0.01518335,-0.05427498,0.021533493,0.004119829,-0.042108648,-0.015937151,0.0031608394,-0.06868008,0.10586143,-0.10813496,-0.032259755,0.06839212,0.024663687,0.076702945,0.061218206,0.0076974863,-0.035821233,0.040480312,-0.040222418,-0.018169653,-0.06781587,-0.04018912,-0.063059986,0.027933298,0.0021834497,-0.053122416,-0.0023260238,0.008037724,-0.017485596,-0.024064312,-0.027962683,0.037254445,0.0011205821,-0.037927963,-0.05572101,0.041044343,-0.022238363,-0.009012079,0.01597056,0.054330483,0.07500767,-0.034703165,-0.12838991,0.054591294,-0.04326277,0.057650615,-0.010148516,0.041336235,-0.10810306,-0.040590063,0.07453892,0.011321611,-0.021685328,0.028893735,-0.08716166,0.092187285,-0.06585525,-0.037131596,-0.035710648,-0.01894755,0.0399939,0.025216302,0.17279668,-0.08788248 +2.3.1.234,"The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg [3]. 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It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules.",384,1.0,-0.06814039,-0.0026877595,-0.15236741,-0.0030168565,-0.05179777,0.039174434,-0.022941783,0.061329223,0.10976482,-0.06304685,0.020216543,-0.08666047,0.07025772,0.0307206,-0.12119047,-0.057975266,-0.068039626,0.026854774,0.053233612,-0.09449452,0.025307612,0.07615301,0.032479234,-0.044141773,0.036186166,-0.005948411,-0.008629292,0.025215464,0.00021189154,-0.06699704,0.015766224,0.02485215,-0.023817247,-0.041921422,0.09487906,0.10969562,-0.05506064,-0.009854789,0.09776645,-0.0033027935,0.060302593,-0.03693775,-0.014090821,0.0736186,-0.03983694,0.021906516,-0.041086234,0.046963602,0.008648827,-0.07183921,-0.034783807,-0.031978846,-0.112207696,0.086391926,0.056261413,0.028141998,-0.01865969,0.031465683,0.017909769,-0.043964315,0.08179007,-0.011090387,-0.00052334246,0.0036708913,-0.01935972,-0.03106099,0.012355601,0.009631245,0.0196073,0.032305606,-0.11861221,0.0121709965,-0.04295843,0.14065368,-0.0006582285,5.6650642e-05,-0.045119744,-0.03560582,-0.07013994,0.0480983,0.042863186,0.0005605811,0.005544466,0.057750307,0.027829189,-0.04447729,0.05125372,0.030391358,0.012170867,0.08820008,0.03909661,0.025328139,0.0051642875,-0.062569775,-0.039269805,0.024939368,-0.013595607,0.0048125214,0.023870552,-0.03151191,-0.08487306,-0.032369964,0.027178656,-0.010774182,-0.037692547,0.005853916,-0.04703975,0.04936838,0.08481084,-0.05856763,-0.06592818,0.028540758,-0.00045982352,-0.08451459,-0.01876201,0.0681758,0.012247485,-0.056358404,0.063690946,-0.034712415,-0.02411436,-0.020194884,-0.035064746,0.043169864,0.00083966367,0.018122599,-0.10446857,2.3858333e-33,0.077946365,0.073502764,0.033828378,0.032517508,0.052998815,-0.018218512,-0.026243022,-0.029724833,-0.06296114,-0.008633571,-0.066941105,-0.10931707,-0.014134731,0.028720831,0.07806022,-0.0320631,-0.05961382,0.035423953,0.049939044,-0.019664593,-0.0014429196,0.07319145,-0.008128075,0.019416932,0.020876735,0.081483595,-0.012906615,0.046238907,0.06254372,-0.017100409,-0.03318299,0.041402027,-0.058938645,0.024458744,0.099790856,-0.024658548,-0.023512932,-0.05608777,0.114420965,0.04520034,-0.010429329,-0.026485207,0.025277263,-0.02642178,0.009637325,-0.01951667,-0.075303815,0.020741386,0.031611152,0.07269216,0.041668527,0.01125405,0.042661823,0.027808942,-0.059711616,0.07582546,-0.050933886,0.006768709,0.0076686083,-0.007846155,-0.024688695,0.009862311,-0.043146167,0.005855134,-0.01784723,0.06996664,-0.066182695,-0.07029288,0.0024677082,0.028854582,-0.040660568,0.025641587,0.040992394,0.022234729,0.086967014,0.045637902,-0.1007172,0.0051557785,0.025236996,0.016050328,-0.020066831,0.002853138,-0.01026211,-0.10709317,-0.027295923,-0.019494055,-0.034314647,-0.016012719,0.03649306,0.019307334,-0.0035087683,-0.055678017,-0.02827611,0.05981302,-0.019624507,-3.9608146e-33,0.12502418,-0.07452942,0.053071875,-0.04302513,-0.10076382,0.019029485,-0.039253052,-0.039628107,0.013308399,0.05900664,0.082579374,0.019181406,-0.010193914,-0.046363425,-0.006237004,-0.046374522,0.041036036,0.03679731,-0.06340413,-0.037317593,-0.0060413056,0.035925113,-0.044859495,0.015287079,0.027179817,0.025478417,-0.061889328,0.06669428,-0.00985064,0.04046994,0.0030858521,-0.092144445,-0.01883558,0.020843968,-0.061347086,0.039696887,-0.042038493,-0.016698541,0.039413225,0.04277357,0.07962655,0.017913599,0.0005026224,0.047557622,0.07325157,0.05980574,-0.045681704,0.04006109,0.01905311,-0.097165264,0.033102285,0.07892636,0.01484423,-0.052289546,-0.03533906,0.034983907,0.04944074,0.00077366387,0.028368158,-0.07580524,-0.012675134,-0.08986769,0.027780363,-0.02484777,0.058516875,0.07398528,-0.03357997,0.067394815,0.08611586,0.0043437253,0.033752505,-0.004529034,-0.03429722,-0.025740055,0.015906183,-0.08299383,-0.08543785,-0.015295957,-0.050140724,0.011665058,-0.0031664744,-0.015882967,0.0008530274,-0.056128614,-0.024711614,0.0132818045,0.029901106,0.053193472,0.006836671,0.026752254,-0.048226606,0.055231094,0.015721053,0.111436814,0.072059564,-4.222991e-08,0.0023842626,0.0050948528,-0.045256287,-0.041351374,0.030514829,-0.04301996,-0.015435655,-0.01029763,0.078305036,-0.013739363,-0.07564534,0.021672836,-0.0018284207,0.051828295,-0.014170732,0.030525291,-0.07532321,-0.024648925,0.036634892,-0.0552005,-0.07721843,0.021113865,-0.071602926,0.10204332,0.007999194,-0.042381506,0.07524744,0.048349977,0.019416181,0.065206856,-0.0022577029,0.040425714,-0.067043364,0.06394873,-0.08155786,0.0030728406,-0.084835,-0.047289737,0.029180327,0.037512787,0.029800983,0.023785165,-0.069839574,0.056860138,-0.050269447,0.031469904,0.021308292,-0.066257596,-0.05480531,-0.070996396,0.058914613,0.078408375,-0.06379285,-0.014518857,-0.055408627,0.030938858,-0.039571878,-0.03249848,-0.069747254,-0.090799995,-0.06119518,-0.06466148,0.16763762,-0.047833733 +2.3.1.236,A multi-domain polyketide synthase involved in the synthesis of azinomycin B in the bacterium Streptomyces griseofuscus.,384,1.0,0.0090702865,-0.027814897,-0.13697611,-0.08252507,-0.016614484,0.034128126,-0.022448463,0.032846287,0.07774232,-0.0061591556,-0.065763585,-0.026478203,0.15401597,0.011698512,-0.050636385,-0.020675186,-0.07798161,-0.0030167613,0.061177053,-0.019864898,0.093055956,0.07637559,0.015524288,-0.03358403,0.04718915,-0.009783826,0.013945388,-0.03732899,-0.09558225,-0.041403383,0.054089054,-0.01441962,0.018576663,-0.064676255,0.075979225,0.0634901,-0.0576544,0.0016879529,0.15186551,0.00073890603,-0.012911758,0.030908545,0.043052185,0.024187962,-0.03801958,0.101253815,0.02469776,0.03450183,0.0033650682,-0.033388462,-0.045828566,-0.0588826,-0.049569804,0.06197238,0.10231497,0.062861115,-0.023525646,0.034650527,-0.004696861,-0.015730256,0.083844714,-0.0058310996,0.09489741,-0.056531683,-0.0822447,-0.043563545,0.02527903,-0.019729864,-0.0061707227,0.016348364,-0.12568021,0.06264075,-0.029207785,-0.010264682,0.018554984,0.032886658,-0.029399917,0.0129478,-0.04296542,0.019469054,0.06308796,0.0033210267,0.06397475,0.037154,0.04927841,-0.017982082,0.09154016,-0.0024895642,0.06750994,0.05792317,0.056108765,-0.02630262,0.015857773,-0.05001511,-0.020830628,-0.0602932,-0.107619755,-0.008237058,0.067621075,-0.03140265,-0.019244831,-0.05934642,0.08200736,-0.013384404,0.014716839,-0.0048583555,-0.0016310753,0.09869012,0.022321507,-0.019876443,-0.017554104,0.01696285,0.015928235,-0.07043107,-0.025230788,0.056534342,0.12562434,-0.02299811,-0.1044072,-0.023915518,-0.01443448,0.07417271,-0.02013899,0.0022293092,-0.042177975,-0.011644157,-0.114296585,1.0450036e-33,0.005946597,0.097776584,0.02884741,-0.025081126,-0.007376708,0.027366782,-0.050436445,-0.028599158,0.033458047,-0.03606053,-0.050276075,-0.12986577,-0.0028668628,0.076823436,0.03252611,0.040709965,0.015073689,0.03646939,0.030011952,-0.035214018,0.0017805697,-0.004917931,-0.06593277,-0.049269736,-0.0034627027,0.087163955,0.057849836,-0.002057743,0.10524161,-0.075870976,-0.057333995,-0.010637996,-0.08395779,0.029109731,0.06465712,-0.044828787,-0.0153937265,-0.02745691,0.11996706,-0.0037120334,-0.042560037,-0.020622903,0.019016387,-0.033933334,0.07505705,0.02932682,-0.045491684,0.036939643,0.0602615,0.009208138,-0.022871472,-0.023691421,0.059830707,0.05449889,-0.04497427,0.03106677,-0.010733483,0.026307948,0.014522889,0.030025948,-0.020710478,0.0017257303,0.030245729,-0.002645718,-0.020414926,0.04226064,0.020171963,-0.036800627,0.022635274,0.042862285,-0.0029228474,-0.057349633,0.026837537,-0.02387386,-0.015082643,-0.011343016,-0.106061354,-0.0795311,0.07350696,0.04680393,-0.005908607,0.0062504713,-0.09499457,-0.07306054,-0.03028301,0.011414659,-0.044501957,-0.04188905,0.019922,0.108633064,-0.055730116,-0.074546754,-0.032800227,0.059692286,0.012254739,-1.6521843e-33,0.106039345,-0.021555634,0.07797053,-0.03901824,-0.07331263,0.017928451,-0.020310825,-0.051676273,-0.037149556,-0.022282014,-0.0014004441,-0.02181742,-0.063888535,-0.011925685,-0.044779524,-0.06710915,0.062006596,0.063215695,0.0061187404,-0.007629164,0.028552664,0.029768977,-0.012844775,-0.031703267,-0.005849272,0.012669739,0.012322906,0.09709508,0.029045125,0.08055284,-0.017810116,-0.10172858,-0.076022185,-0.021084776,-0.072354086,0.04128757,-0.011592812,0.022055654,-0.005039657,-0.025278695,0.022055348,-0.011989652,0.028798416,0.08936458,0.016455786,0.045327853,-0.055994254,0.051003393,0.042397983,-0.05871604,-0.030641649,0.04846624,0.026683936,-0.036308553,-0.04109933,-0.042372588,0.0048533543,-0.017081069,-0.06199163,-0.056597337,-0.053172328,-0.006040801,0.026864082,-0.048705224,-0.002808099,0.07551485,0.039618753,0.040004537,0.09300206,0.016802419,0.025725491,0.026663119,-0.0106163975,0.05279954,0.025647122,0.0122629255,-0.08366233,-0.05667693,0.008059888,-0.0010570033,0.05376416,-0.009612021,-0.016075274,-0.019043867,-0.0042373296,-0.010089659,0.04681613,0.03236714,-0.0017370699,0.012487672,0.021279164,0.06476294,0.029105153,0.06585288,-0.05336126,-2.2760394e-08,0.05099957,-0.008607426,0.0070440653,-0.065399654,-0.027004248,-0.02016258,-0.066146694,-0.059292946,0.03834756,-0.056082595,-0.060042933,0.0053315284,-0.014239814,0.05279731,-0.0015812179,-0.023672516,-0.055823475,-0.0059642135,0.037415605,0.009842436,-0.08088251,0.01867856,-0.117731094,0.021949118,0.05329327,-0.056578737,0.028911637,-0.02930844,0.016116269,0.10134455,0.07936941,0.06414495,-0.035145156,0.030838747,0.0070944605,-0.05853512,-0.03789298,-0.03655882,0.054998748,-0.041299846,0.05871525,0.055405196,-0.043587223,0.024421113,-0.08781551,-0.004883171,-0.05253922,-0.07944552,-0.025766732,0.033409562,0.08725776,0.08305065,0.027628185,0.006009335,-0.0831878,0.04165341,-0.018897306,-0.0581684,-0.030536354,-0.001675252,-0.08877655,-0.11770494,0.12031537,-0.026468944 +2.3.1.237,A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.,384,1.0,-0.032311153,-0.021879734,-0.18631852,0.02573984,-0.047053672,0.08171626,-0.06630134,0.06163994,0.08016667,-0.08663725,-0.086435065,-0.058432613,0.017423613,0.0210048,-0.14382239,-0.04919554,-0.09142465,0.06774106,0.10414012,-0.07077049,0.029585462,0.07690932,0.0931409,0.0035808806,0.020603864,0.01180386,0.016216064,-0.031197129,-0.047214683,0.033809297,0.027049588,-0.015548227,-0.044645917,-0.03503275,0.070185415,0.09194399,-0.0016771596,-0.03652744,0.10684923,0.011917407,0.037351537,0.0011978616,-0.0038257127,0.013176418,-0.018858042,0.036175895,-0.007387477,0.023878621,0.02921895,-0.058536116,-0.011996954,-0.06702392,-0.049063966,0.0600854,0.08070874,0.029391386,-0.0021170552,0.036253482,0.07945067,-0.027911268,0.111839026,-0.013839616,0.016999926,-0.0720836,-0.037872303,-0.038153015,0.049266085,-0.009383975,-0.0047966926,0.03539738,-0.10173353,0.061819926,-0.021015575,0.015168683,-0.02677011,0.08046411,-0.006972976,-0.025504572,-0.08108726,0.040128022,0.09870822,-0.003612787,0.054960135,0.05024585,0.0037354806,0.018354123,0.00909145,0.05243074,0.047966342,0.057843037,0.022468207,-0.0029696734,-0.00025174368,-0.026964966,-0.05643728,-0.08542375,-0.030733796,0.045187242,0.071046226,-0.054421764,-0.022613743,-0.03432661,0.055065427,-0.01949496,0.040570274,0.0057250103,0.016880915,0.10406966,0.048551325,-0.060488105,-0.05626473,0.027356965,0.05103417,-0.0734518,-0.012710856,0.07676135,0.00012713988,0.028127626,-0.036023214,0.06666627,-0.027800329,0.059281357,-0.03031428,0.05197261,-0.0127217965,-0.04357076,-0.11486439,7.615877e-34,0.047527358,0.11275706,0.100630835,0.011727278,0.022841386,0.02772028,-0.059985097,-0.06261584,0.012793528,-0.019653512,-0.015264578,-0.09826609,0.009804278,0.053216893,0.055224158,-0.00026456406,-0.0062736915,-0.035036463,0.054470584,-0.05388828,-0.011302092,0.02746907,-0.0578622,-0.026127744,-0.0037480183,0.03642387,0.03715822,0.06703693,0.024502855,-0.05326985,-0.05872092,-0.014251753,-0.065058306,0.02749455,0.1117709,-0.06121179,-0.013516397,-0.05332758,0.0979773,0.020037308,-0.037808105,-0.049688756,-0.029012926,-0.033513237,0.06445562,-0.029478392,-0.040845364,0.08652743,0.012032218,0.06660865,0.0042597856,-0.033925682,0.039995894,0.053480677,-0.08869578,0.018177342,-0.013274099,0.009176107,0.019908488,0.047616363,0.017295491,-0.028427681,-0.029842572,-0.007374999,-0.008924872,0.047125075,-0.021469114,0.004538477,0.0030577541,0.023908427,-0.03910749,0.004536203,0.016129352,0.020592244,0.034697838,0.016665468,-0.14492339,-0.022167182,0.04433442,-0.00416943,-0.03692776,0.018042726,-0.09925493,-0.048459984,-0.031988688,0.059898116,-0.018761558,0.0028475674,-0.012881673,0.08355871,-0.025377626,-0.13431479,-0.017337361,0.040058285,0.008602329,-1.8145972e-33,0.09299552,-0.019275924,-0.008913883,-0.04958265,-0.05223522,0.0034081913,-0.01857868,-0.08578974,-0.07514368,-0.062393796,0.052700873,0.0059728175,-0.008923256,0.013549246,-0.040565073,-0.035232197,0.016215404,0.025558468,0.01922144,-0.046349738,0.0032130696,-0.018319458,-0.06922964,0.06399784,0.012333727,0.010276167,-0.0144631,0.09640596,0.007592126,0.09115918,0.0086611435,-0.08144038,-0.026307803,-0.023384877,-0.03733542,0.038121957,-0.0009837038,0.014143971,0.0803543,-0.0027918573,0.016134102,-0.01566112,-0.021835878,0.08150213,0.07080086,0.10052082,0.0045608203,-0.0032108654,0.018523926,-0.009034448,-0.035971183,0.055773016,-0.013998278,-0.04276848,-0.043294888,0.0040889797,0.020011386,-0.0078822775,0.05600524,-0.071119,0.01593991,-0.015768085,0.06777225,0.0047182916,0.019366436,0.05698278,0.054342717,0.051265903,0.16010872,-0.04133564,0.039106887,-0.010605974,0.020816924,0.07184203,-0.07091327,-0.04596115,-0.014524254,-0.036372658,0.004190376,-0.027094683,0.010527312,-0.051116616,0.026143963,-0.08456479,0.005665703,0.013859663,0.0668137,0.024497036,-0.026939968,0.020095821,0.00869245,0.037728198,-0.027978389,0.047586285,-0.0006644877,-2.3885775e-08,0.0766257,-0.055663448,-0.0020847556,-0.07105262,0.016022392,-0.037311185,-0.014489539,-0.0429345,-0.006554587,-0.020115327,-0.07471662,-0.049643844,-0.0143741425,0.04069368,-0.02917498,-0.011627904,-0.046694104,-0.0108697275,0.020051405,-0.017155033,-0.09581612,0.04187567,-0.08925253,0.04892186,0.04345685,-0.10257699,0.025432069,0.04940285,0.052601818,0.068393335,0.08070599,0.016588695,-0.018509425,-0.033539567,-0.021870373,0.003305455,-0.06953013,-0.05204629,0.0360498,-0.08806584,0.01226698,0.0635991,-0.028691333,0.021003122,-0.045358155,0.004204455,0.006496069,-0.040234186,-0.017917847,-0.0012202872,0.08574671,0.029609231,-0.0070779803,0.020258332,-0.059476733,0.062718764,-0.015154598,-0.002368469,-0.05589466,-0.0068154787,-0.12580316,-0.0917696,0.11044715,-0.06266504 +2.3.1.238,The enzyme catalyses the ultimate reaction in the lovastatin biosynthesis pathway of the filamentous fungus Aspergillus terreus.,384,1.0,-0.046374712,0.03011431,-0.14289066,-0.035430342,0.11279986,-0.013497328,-0.112431794,0.061840534,0.016638717,-0.04640291,0.035568643,-0.05554415,-0.03656584,0.0016163,-0.071550526,0.009542177,-0.013416033,0.009417457,-0.014622475,-0.04705146,0.123665415,0.01780151,-0.00047187053,0.045405496,0.036521237,0.0059856568,0.052311365,-0.050721228,-0.04057231,-0.08408139,-0.07129552,-0.017753435,-0.03230693,-0.081882425,0.028258111,0.06141233,-0.029067865,0.0021153274,0.07318548,0.009766563,0.023040963,-0.08068833,-0.014595273,-0.110119395,-0.048690073,-0.06268035,-0.026161488,-0.001009517,0.05074255,0.013501065,-0.110747315,-0.020670556,0.0044584363,-0.018924009,0.06695949,0.017389428,0.00024606977,-0.07256534,-0.026427645,0.047165908,0.006152079,-0.045170993,-0.019990636,0.0017052151,-0.051242914,-0.080660865,0.02476364,-0.016531134,-0.0678949,-0.0026440977,-0.026221339,-0.038037628,-0.030192707,0.0014926407,0.121484645,0.07926032,-0.059587736,0.004303537,0.010684554,-0.016807504,0.10264557,0.01657444,0.059349075,0.041389614,0.03754343,-0.010092452,0.032140017,0.08152252,0.01647079,0.061256237,0.034516156,0.03763535,0.0017063689,0.010927049,-0.060762256,0.10189292,0.015662704,0.057628978,0.025957678,-0.026503026,0.028674986,-0.016777406,-0.0011204056,-0.06574797,-0.004380319,-0.06901567,0.012022019,0.08834463,0.09986673,-0.05278247,0.033423174,-0.06454932,0.04199327,0.019562222,-0.019606683,0.024176292,0.037409946,-0.011031681,-0.099598214,-0.00786917,0.072672755,0.047067847,-0.025799789,0.06266505,0.0044952496,-0.003116742,-0.07794138,1.8182756e-33,0.105875425,0.06931353,-0.05739118,-0.040921953,-0.013645847,-0.042999655,-0.01385333,0.004702638,-0.020962676,-0.020267459,-0.096749574,-0.056157477,-0.09253416,0.045143627,-0.043531753,-0.043881204,0.03314907,-0.03617979,0.03540713,-0.0244436,0.06972342,0.014398495,-0.08733142,0.048219703,0.06659724,0.109454975,-0.014953269,0.04968487,-0.019498823,-0.0049093454,0.061617456,-0.07959517,-0.048809253,0.008971308,0.13440047,-0.046097178,0.008149274,0.014053071,-0.045526505,-0.0061828215,-0.025416484,0.046649292,-0.05559201,-0.0782969,0.025872698,0.018136643,-0.058919102,0.07994028,0.0722067,0.06124595,0.035950415,-0.004255885,0.14120363,0.040912718,-0.021035017,0.0040094657,-0.082357325,-0.061979573,-0.009487859,0.013193211,0.0010747132,0.010714202,-0.016793638,0.039804365,-0.015963271,-0.023774726,-0.041759256,0.03583317,-0.0014000608,-0.011663701,0.017584464,0.07193133,-0.057602685,-0.02935381,0.04359757,-0.021230131,-0.036443513,-0.0039568176,-0.037557803,-0.0015390962,0.009326267,0.047911774,-0.007879282,-0.05431043,-0.064712554,0.067225836,0.027138442,0.04184331,-0.02595817,0.04433543,0.014031677,-0.074438766,0.037501816,0.014380283,0.010488486,-2.4585518e-33,0.09589767,-0.11212215,0.04385499,-0.02594219,-0.053950295,0.0759941,0.013880311,-0.019596366,0.0056599625,-0.010244583,0.012826508,0.02452904,0.0123447655,0.0068627526,0.0014850363,0.003561321,-0.006311651,0.055178918,0.019697592,0.0021800674,-0.038000528,0.05632642,0.020624323,0.026765138,0.08419116,0.034100838,0.011171311,0.0090741655,-0.019945666,0.10639432,-0.03246164,0.0015802695,-0.04869212,-0.006868688,-0.081825174,0.103289016,0.015083752,0.017659774,0.029824948,0.06477122,-0.0119879125,-0.030034909,-0.0051709334,0.03670176,0.020717243,0.048788674,-0.009568958,0.031693906,-0.010611743,-0.062321424,0.030709993,0.0811783,0.0329737,-0.025027936,-0.0054491875,-0.05590491,0.051776398,-0.008772586,-0.009774461,-0.0854297,-0.057194587,-0.059040487,-0.072423056,0.007099882,0.04502324,0.096878186,-0.07648605,0.010576843,0.020440893,-0.085254766,0.11004655,-0.0041752537,-0.035753615,0.037051797,0.047175445,-0.035443928,-0.05641531,0.010820745,-0.010061862,0.035328113,-0.037879247,3.7135556e-05,0.0018828078,-0.11061705,-0.07642801,-0.08538884,0.08287054,0.029327432,-0.048642065,-0.015330073,-0.033312734,0.041866165,-0.0068611405,0.050908633,0.022263626,-2.503543e-08,0.043985818,-0.033177722,0.020493153,-0.07091396,0.022496331,0.015161772,0.087103546,0.02702204,0.05403308,-0.012147719,-0.035364594,0.09399808,0.060574733,0.017078014,0.07637334,-0.0329704,0.016149707,0.03576888,0.015128811,-0.0025328514,-0.024058014,-0.008693204,-0.16091588,0.045074467,0.041231427,-0.04379546,-0.025724476,-0.041814923,0.08309,0.0150506785,0.021068173,-0.0013249388,0.0071649672,-0.06701936,-0.06734596,-0.024276452,-0.018509187,-0.05309901,0.044447016,-0.025560712,-0.021022627,0.009828923,-0.07475585,-0.038864717,-0.11516605,0.0026012573,0.04152129,0.023529364,0.0011887588,0.020347165,0.023323558,-0.067086846,0.00024840137,-0.011868861,-0.09469306,-0.058222223,0.1130652,0.0045292163,-0.026866307,-0.0274641,-0.007262658,0.032115582,0.17246844,0.0014124451 +2.3.1.239,"The product, 10-deoxymethynolide, contains a 12-membered ring and is an intermediate in the biosynthesis of methymycin in the bacterium Streptomyces venezuelae. The enzyme also produces narbonolide (see EC 2.3.1.240, narbonolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis.",384,0.99999994,-0.050728586,-0.0686084,-0.13261412,-0.07763265,0.040897425,0.058375824,-0.03726711,0.0912774,0.06216452,-0.021770297,0.041862432,-0.011109941,0.052559327,-0.00043224843,-0.040128604,0.03616803,-0.04799156,0.0034329158,0.059398454,-0.08110089,0.054475214,0.08721158,0.028039679,-0.0717598,0.069871396,-0.06480135,0.006483556,-0.0154244425,-0.041760333,-0.058329906,0.05170284,-0.016654208,0.015581615,-0.045591038,0.09850635,0.08980341,-0.09970484,-0.063644215,0.09672281,0.016207328,0.043779053,-0.018207256,0.054884113,0.012491834,0.016477156,0.006475948,-0.07759579,0.07764894,0.02819771,-0.06373614,-0.034714513,-0.06187663,-0.01910523,0.0812014,0.021374673,0.035488125,-0.07160202,-0.02533277,-0.019858446,0.004734145,0.06597458,0.0199605,-0.028784953,-0.02762353,-0.056103386,-0.05394492,0.07931886,-0.025990024,0.077137336,0.050955053,-0.03802949,-0.03364299,-0.009605149,0.034502942,-0.020731488,-0.026033891,-0.02357027,-0.05272647,-0.042671993,-0.03825687,0.01603219,0.030894551,0.10494432,0.0010771112,0.04052554,-0.037253857,0.030709088,0.053896587,0.0053305025,0.032148022,0.036667947,-0.04807794,0.008393626,-0.053888164,-0.080706574,0.0049739676,-0.022652846,0.045606975,0.024978412,-0.010161165,0.008892453,0.026616026,0.048985817,-0.08028244,-0.031101562,0.024637915,-0.0060592704,0.042066406,0.01274279,0.014832395,-0.033144794,-0.02514712,0.0075712334,-0.044418976,-0.0020981035,0.050468743,0.055069756,-0.074446015,-0.04851318,-0.035265446,0.010442563,-0.027199542,0.04904705,0.02640893,-0.047103427,0.013342636,-0.13711627,2.9291545e-33,0.043992735,0.019278152,0.005853482,-0.044975087,0.035090055,-0.01861772,-0.094870225,-0.0014726965,-0.03107167,-0.040797733,-0.11594357,-0.07325555,0.047497302,0.03844298,0.0045625386,-0.04318603,0.0120191,-0.0132236825,0.050588936,0.035175055,-0.011010081,0.04646693,-0.0704666,0.09313974,0.011739086,0.08684229,-0.04421579,0.030703967,0.0138677675,0.00014497402,-0.008116968,-0.03606854,-0.07996861,0.0946073,0.05721977,-9.912562e-05,-0.028514763,-0.06506079,0.03216608,0.02313307,-0.027565733,0.0024754505,-0.011172177,0.009980214,0.09516537,-0.053931948,-0.062145803,0.09190509,0.08299883,0.08749008,0.03430682,0.008378079,0.122959666,-0.026744163,-0.064978026,0.026818678,-0.06582232,0.021769721,0.07581739,0.087820485,-0.02960653,-0.006123233,-0.010252164,-0.029821249,-0.02019105,0.057250727,-0.04565303,-0.054049116,0.053479698,0.07418777,-0.054195166,-0.0033080266,0.055981815,0.04591709,0.0725602,0.011193664,-0.06589722,0.009565359,0.009341846,0.055241145,-0.017401593,0.003614135,-0.023519136,-0.052069094,0.01430185,-0.0093972,-0.056596078,-0.037683167,0.0063201757,0.011790162,-0.0005662217,-0.05804219,-0.062248662,0.05596347,-0.003243393,-3.0281535e-33,0.12431544,-0.048877925,0.009932285,-0.034383945,-0.05493921,0.046192143,0.02168771,-0.0034320124,0.00995438,-0.017347168,0.062219255,0.000262152,0.0015748488,-0.057356514,0.0019422099,0.013899171,0.0020059461,0.118214466,-0.028992083,-0.0037541585,-0.0314619,0.05449282,-0.017297052,0.02640902,0.022560878,0.041685775,-0.044228464,0.0013050177,0.054374825,0.022449447,-0.02700925,-0.071186945,-0.06974693,-0.039061096,-0.075314626,0.068464905,-0.08773184,0.0245227,0.009341323,0.021320656,0.12162575,0.04583243,-0.023956452,0.049136892,0.033425838,0.047746744,-0.08818863,0.056057684,0.009788624,-0.15409732,0.024292024,0.009203495,0.04338011,-0.01558662,0.0120373815,0.0748374,0.079245955,0.011648366,-0.039245684,-0.023434712,-0.03134985,-0.06042875,0.047082376,0.030881006,0.060832903,0.072295964,0.004429565,0.15038441,-0.0058221337,-0.0025433768,-0.011789774,0.08516886,-0.015806954,-0.020682348,-0.036852114,-0.05672757,-0.09293589,-0.058104366,0.003651608,-0.020979235,-0.007892038,-0.05437378,0.016813472,-0.05929243,-0.014670951,-0.012082621,-0.0052319122,0.0030558659,0.053655267,0.020518512,-0.010410342,0.05506043,-0.08088067,0.11355598,0.019326756,-4.5996178e-08,0.08655274,0.009228529,0.057483576,-0.09431808,0.079390585,-0.011170642,-0.0028820627,0.009690249,0.009101695,-0.0062456117,-0.0092404615,0.05752497,-0.027003737,-0.020924876,0.0044023935,0.01419394,-0.0073214155,0.075414926,-0.032549743,-0.019422142,-0.044805374,0.017120745,-0.04740528,0.07235898,-0.0022233245,-0.020550778,0.042626016,0.04940486,0.008331108,-0.045322955,-0.012718194,0.025442043,-0.07898557,-0.005173597,-0.05087353,-0.0009133733,-0.049347878,-0.06368704,-0.0047053304,0.024239095,-0.013295207,-0.08652298,-0.02169556,0.05827722,0.0033456408,0.02496479,-0.0028550054,-0.056434084,-0.060627792,-0.023371872,0.021066891,0.028000219,-0.0076855756,-0.026245425,-0.1329846,0.007852663,-0.023746692,-0.07061298,-0.03107233,-0.06382182,-0.06842406,-0.013333214,0.2166955,0.005188795 +2.3.1.240,"The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae. The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239, 10-deoxymethynolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis.",384,1.0,-0.06405402,-0.061194167,-0.15874873,-0.05627319,0.029933594,0.058848873,-0.03900889,0.0936061,0.08009144,-0.034333862,0.04349007,-0.004775384,0.051553067,-0.0015023319,-0.043173984,0.016903682,-0.05305062,0.02052191,0.059035264,-0.084271856,0.05941364,0.060279436,0.019656159,-0.05870588,0.059577346,-0.05259967,0.017744387,-0.051199645,-0.0657338,-0.07288988,0.048084427,-0.02450686,0.012413621,-0.052413374,0.10781698,0.08408169,-0.10919565,-0.061573386,0.105008915,0.008430116,0.046429873,-0.005222809,0.043777023,0.014462404,0.0062363734,0.023376726,-0.07591258,0.062408637,0.024844697,-0.0569375,-0.026193097,-0.040543683,-0.027889201,0.08619922,0.014316608,0.017760826,-0.06608643,-0.035539888,-0.011004019,0.021998297,0.06829186,0.013208695,-0.026920898,-0.025411298,-0.09095181,-0.04315049,0.07381203,-0.040991057,0.033067994,0.043700255,-0.041610822,-0.029150648,-0.0014214085,0.06122845,-0.015553286,-0.0014169778,-0.018408936,-0.02914706,-0.07370078,-0.008585854,0.023969864,0.015969785,0.096160024,0.021514906,0.03551906,-0.035265762,0.024654808,0.074713916,0.00823804,0.0706485,0.057048045,-0.015537225,0.013249633,-0.049901724,-0.069690295,-0.015105026,-0.055383913,0.045460463,0.01570377,-0.02308235,0.0048418283,0.016539192,0.06460381,-0.09386959,-0.028240202,0.026248667,-0.0136961015,0.041522708,0.039200723,0.010002624,-0.04631104,-0.017384985,0.00052365824,-0.063304245,0.0023333393,0.0670927,0.064989954,-0.07418926,-0.047533564,-0.028626028,0.018746026,-0.027458759,0.04275724,0.029140484,-0.048485216,0.0105320485,-0.14594764,3.1082995e-33,0.020384267,0.039647456,0.013654938,-0.041106425,0.024085259,-0.003400913,-0.0930309,-0.01909572,-0.03663468,-0.059074905,-0.10735758,-0.062122755,0.040349662,0.026761692,0.029592603,-0.021379305,0.003345588,-0.00055067195,0.06816931,0.038177826,-0.0052932086,0.044451725,-0.076102346,0.09171989,0.032608546,0.09819093,-0.040053822,0.0017013527,-0.015916256,-0.012491218,-0.016705751,-0.03990361,-0.060214955,0.08118223,0.06897376,-0.026951917,-0.0048108115,-0.061945528,0.03299731,0.040765755,-0.04443465,-0.0055960612,-0.015161903,0.017989026,0.09487432,-0.065774634,-0.053978413,0.09029984,0.07374173,0.1048988,0.02987409,0.0064286757,0.12701412,-0.020664796,-0.06785636,0.036634315,-0.06704164,0.03582245,0.08618275,0.058001325,0.007267492,-0.011800594,-0.004527759,-0.05652408,0.0082898885,0.06694887,-0.06040716,-0.048341196,0.03324705,0.07125876,-0.06638086,-0.018149026,0.06569365,0.039653007,0.07210237,-5.5823915e-05,-0.08982772,0.027990352,0.012253879,0.06284651,-0.036650475,0.01296357,-0.025833528,-0.070028715,0.020117125,-0.006699651,-0.04432634,-0.026802815,0.0033177112,0.0053245947,0.0029089975,-0.057004526,-0.06074143,0.05923567,-0.003552904,-3.5376686e-33,0.12390416,-0.06168955,0.004054219,-0.035316307,-0.039423298,0.05371584,0.010489881,-0.0050398093,0.00203696,-0.017753607,0.049462836,-0.014905784,0.0077065737,-0.055534802,0.01213395,0.0074434234,-0.014795783,0.12756614,-0.028420566,-0.023394814,-0.037270326,0.060174894,-0.0087866625,0.04426191,0.01599449,0.036355175,-0.050106496,0.015735563,0.058610834,0.033343147,-0.0332093,-0.05871658,-0.051358845,-0.023734566,-0.074954145,0.077456705,-0.08080315,0.041874196,0.035367534,0.012146112,0.10893496,0.024739338,-0.010834981,0.033644617,0.015002894,0.027538983,-0.06285518,0.055713195,0.013070393,-0.1567695,0.012649385,0.036135793,0.026236799,-0.009800303,0.0012613139,0.06682437,0.06383726,0.027662657,-0.030153545,-0.031697527,-0.043172847,-0.06236517,0.05642759,0.030095018,0.046465807,0.061845176,0.0050862953,0.1295953,0.014063546,-0.009494134,-0.014867189,0.07528217,-0.030190624,-0.012027512,-0.02540571,-0.0475926,-0.080480084,-0.064588435,-0.013564739,-0.008253319,-0.0078768395,-0.049008742,-0.001212439,-0.065099604,-0.013078918,-0.017750055,0.005013841,-0.011506695,0.045260504,0.011344709,-0.0075389254,0.05874569,-0.07109132,0.11013438,0.008938699,-4.6252396e-08,0.07503133,0.016553681,0.05808021,-0.07042816,0.076155335,-0.02394403,0.0016039565,-0.0034460952,-0.014501727,-0.013150579,0.0012765132,0.040077217,-0.023689866,-0.007866197,0.025909884,0.03035922,-0.032961015,0.080585726,0.003158477,0.004045673,-0.036582705,0.00926199,-0.058605276,0.068101645,-0.011290757,-0.018753765,0.047998063,0.030862203,0.016947081,-0.022366697,-0.009720544,0.019151594,-0.0785935,-0.011511444,-0.04134082,-0.013683289,-0.06487967,-0.06773159,0.0015526043,0.024055988,-0.015557519,-0.07179027,-0.040722154,0.058518928,-0.021206021,0.03278685,0.007420296,-0.07040912,-0.054466136,-0.026165932,0.023827806,0.026387237,-0.028469041,-0.031927604,-0.11509471,0.03225102,-0.008669089,-0.06675048,-0.020811917,-0.053560793,-0.06957278,-0.005015648,0.22417009,-0.0022292738 +2.3.1.241,"The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A. It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached to the nitrogen of the non-reducing glucosamine molecule. The enzyme from the bacterium Escherichia coli is specific for lauryl (C12) acyl groups, giving the enzyme its previous accepted name. However, enzymes from different species accept highly variable substrates.",384,0.99999994,-0.070173934,-0.049468815,-0.09077245,-0.027998243,-0.031601153,0.021238903,-0.06602039,0.002746888,0.041049518,-0.060028028,0.034439627,-0.01069938,-0.07514294,0.043381676,-0.044396456,0.044094477,-0.04701333,0.01319155,-0.089404315,-0.078592815,0.120179616,0.0028946,-0.037639514,-0.06427673,0.008334628,-0.0395421,0.049250122,-0.062459793,0.009705057,-0.029421574,-0.04349799,-0.051745296,0.06609751,-0.07918833,0.06120791,0.04913714,-0.00094533025,-0.045756686,0.103530854,0.04424971,0.019787483,0.0017671568,-0.00048120713,0.004039436,-0.054468516,-0.044316743,0.025372583,0.07947312,0.007479104,0.019297294,-0.011487613,-0.045674812,-0.041192412,0.039509494,-0.06715276,0.080333576,-0.037811708,-0.062354583,-0.065443896,0.02809223,0.025985714,0.02937832,0.042835034,0.027439348,0.02489507,-0.11782741,0.08168762,-0.053139076,0.012165259,-0.0526235,-0.10846071,-0.060849708,0.053907663,-0.0053279772,0.06377732,-0.059672724,0.008368303,-0.0007360217,0.057753824,-0.033879444,0.052706897,-0.059801266,0.03134726,0.1142822,0.041895036,-0.07099203,0.026847789,-0.00015110397,0.042149514,0.03199811,-0.025797036,-0.06267153,0.007388677,-0.013071956,-0.046222176,0.037030272,0.08744639,0.027224848,0.0075632413,-0.008367256,0.012600249,0.034231767,0.05179313,-0.02767005,-0.04347751,0.018056037,-0.017323425,0.07784369,-0.047351748,-0.03592477,0.0038017265,0.075036675,0.04205491,0.016463703,-0.029599875,0.040417004,0.013414632,-0.055760913,-0.034128565,0.0024573647,0.014128615,-0.0046463064,0.03815188,0.0569487,-0.06266571,0.108470306,-0.08402265,2.996073e-33,0.033668466,-0.006034371,0.0017985648,-0.09162836,-0.022470372,-0.027061427,-0.072328754,-0.010165349,-0.06467726,-0.010762184,-0.023895217,-0.089259535,0.039072376,0.02737181,0.01904044,0.0072555705,-0.030441247,0.07214419,0.07662387,0.014944702,0.05090179,0.08649131,-0.013865898,-0.050018925,0.041954603,0.037065722,-0.026459338,0.012327598,0.020189097,0.020060284,0.043803006,-0.08861539,-0.053379204,0.041157085,0.06791916,-0.011529994,-0.07342967,-0.045682814,0.0003899798,0.003289154,0.019532353,0.02656162,0.0044229925,-0.052303128,0.011501038,-0.03888686,-0.09581841,0.06914439,0.030652793,0.078914724,0.01005789,-0.011639412,0.08393918,0.03633338,-0.017388338,-0.011448681,-0.033347655,-0.021496024,-0.011957927,0.0029981632,-0.0129661,0.09420648,-0.084528685,0.03527636,0.018604957,0.037171334,-0.02598862,-0.032995675,-0.009357675,0.10756678,-0.04967042,-0.022421308,-0.0006364071,0.11896024,0.060330708,-0.05422644,-0.027411252,0.0335338,-0.03795579,0.0003169186,0.010111917,0.024517898,0.008899859,-0.040860154,-0.12567033,-0.0010206957,-0.019183928,-0.04160072,-0.0023762726,-0.01833363,0.03127741,-0.030676654,-0.039946336,0.0501439,-0.009785784,-4.4709325e-33,0.096566126,-0.09708821,0.08575939,-0.11411928,-0.04837426,0.0284001,0.0103522865,-0.023428774,0.01482114,0.020857729,0.029413393,0.041390214,-0.032042973,-0.016631298,0.049288,0.04352846,0.022553276,0.026343131,-0.013088318,-0.025477976,0.0324002,0.03798106,0.015827315,0.0322306,0.01656053,-0.05600344,-0.022571918,0.033318672,0.00196577,0.06542995,-0.0507577,-0.011277344,0.0029620742,0.0014802587,-0.028898727,0.018097255,-0.06700882,0.008797247,0.023207404,0.020549629,0.040039208,0.038506396,0.037042968,0.048741255,0.010574489,0.07390596,-0.10107402,0.0035612744,-0.03938981,-0.058585953,-0.015617145,-0.01212741,0.058268864,-0.0026890745,0.06897131,0.10494903,0.054430835,-0.048527412,-0.0014129722,-0.065704085,-0.01849338,-0.0012128042,0.00079564255,-0.009237658,0.05890347,-0.011127271,-0.08338531,0.04491598,0.021356462,0.00073587685,0.049659155,0.033479013,0.030419659,0.0676629,-0.0012380823,-0.018849395,-0.06186118,-0.07687534,-0.032271456,-0.0022893194,0.03871599,0.024899842,0.06973751,-0.045741923,-0.027809974,-0.056685172,0.051734727,0.07915292,0.069283426,0.055612087,0.021320334,-0.031685308,-0.09092044,0.059745833,0.07832111,-4.2576243e-08,0.027759505,-0.07335379,0.07156608,-0.061970484,-0.06947906,0.082838885,-0.010851862,0.018112984,0.058393624,0.026344543,-0.07170501,0.124834195,0.039477754,0.0021304307,-0.04859165,0.051443662,-0.06557104,-0.019571183,-0.016781604,-0.07041197,-0.08457855,-0.012649298,-0.07345969,0.078489885,0.055447523,-0.039410967,-0.03170855,0.032426577,-0.084305234,-0.033355992,-0.01343303,0.0017598387,-0.009631961,-0.023238128,-0.064317256,0.032152843,0.0067223255,-0.08063268,-0.06710577,0.07703789,0.0609341,0.001190263,-0.03422483,0.026973568,0.09883007,-0.024378013,-0.031483285,-0.005945389,-0.035780903,0.0073811086,0.049271006,-0.045723993,-0.0055381376,-0.0638679,-0.10160318,-0.046084892,-0.082391985,-0.045085315,-0.024245117,0.020900182,0.01931729,0.09976122,0.23779263,-0.028238906 +2.3.1.242,"The enzyme, characterized from the bacterium Escherichia coli, is induced upon cold shock and is involved in the formation of a cold-adapted variant of the outer membrane glycolipid lipid A. ",384,0.99999994,-0.11733588,-0.069274805,-0.072690345,0.06699303,-0.038011055,0.053660877,-0.036050938,0.115561455,0.044380173,-0.045934834,0.02531464,-0.012677082,-0.026507718,0.0661811,-0.010167207,-0.046187855,-0.012085886,0.0067023006,-0.09114765,-0.083181426,0.087473676,0.05032471,-0.054835673,-0.029277653,-0.02498799,-0.0014176704,0.040450875,-0.01917883,-0.024917157,0.006482315,-0.031202536,-0.0497808,0.053629357,-0.035037387,0.071865045,0.06987685,0.015505514,0.038689908,0.044114813,-0.010213518,0.023857784,-0.057297982,0.01922889,-0.00030901475,0.034269042,0.010449566,-0.014880941,0.120113924,0.039378993,-0.015523257,-0.045519423,-0.020002535,-0.06303706,0.03218455,-0.05687744,0.051721893,-0.04713787,-0.07231204,-0.009703843,-0.00984471,-0.0049517043,0.039596673,0.11441508,0.069259524,0.06334368,-0.11551564,0.08158694,-0.05821643,0.04805968,-0.030977422,-0.023556892,-0.008652846,-0.061171345,-0.056228485,0.0073291147,-0.031192929,-0.012364277,-0.014999782,0.037490036,0.0026015113,0.13144672,-0.11573958,0.034119997,0.11711395,-0.030074297,-0.021483108,0.11141671,-0.044781234,0.052569043,0.10689894,-0.0025083558,-0.038207155,-0.005223675,-0.0027014357,-0.09222658,0.0017277076,0.0067319004,-0.049465552,-0.035925753,-0.026704062,-0.028733749,-0.039074432,0.006499525,0.026897477,0.023621365,-0.026344562,0.04895691,-0.04862841,-0.030782815,-0.022390613,0.0227913,0.010401835,0.013477717,-0.066382356,0.027262043,-0.0040985853,-0.027570087,-0.036507968,-0.03846634,0.0036064202,-0.022473522,-0.001030017,-0.018382512,0.042404275,-0.056246985,0.098177515,-0.07161972,-7.174895e-35,0.08680709,-0.01949885,-0.002631881,-0.008435701,0.001307644,-0.10654567,-0.05793889,-0.008009522,-0.093542494,0.029345058,0.0032076337,-0.093539275,0.043114796,0.06923709,0.03866636,0.052741885,-0.0675917,0.01530294,0.041079156,0.03607731,0.003431939,0.0593678,0.0773152,-0.01060035,0.06276733,0.051724385,-0.08151078,0.029742757,0.03522633,-0.010520364,0.0036693155,-0.13869815,-0.12928677,0.034699835,0.083168216,-0.004123435,-0.030197652,-0.04945011,0.0033467351,0.0023373596,8.1696366e-05,0.016541831,0.021873824,-0.056862447,0.05479631,-0.009900975,-0.12462694,0.053683512,0.03856825,0.005370533,0.05215127,-0.012145596,0.13153023,-0.024794169,0.027445043,-0.028271893,-0.006062236,0.07674807,0.013685273,0.019753156,-0.032530084,0.07331209,-0.08138161,0.006815407,0.054737672,0.068873666,-0.038742617,-0.05233888,0.017369568,0.049961742,0.00046030633,-0.035934057,0.027400503,0.056283824,-0.022459839,-0.048459675,-0.013752213,0.026205286,0.01056834,-0.030389681,-0.010688816,-0.021559967,0.037762884,0.0011473956,-0.078153335,0.024587683,-0.038861882,-0.0344338,0.002976875,0.04448922,0.046871778,-0.04655332,-0.013340281,0.0964209,-0.0055956286,-2.429645e-33,0.04336522,-0.102032036,0.026771817,-0.06554911,-0.08617644,0.1179819,-0.069390856,0.015186059,0.030395865,0.01639231,-0.01054319,-0.005918099,0.01048211,-0.020136941,0.016455242,-0.00080017396,-0.00619413,0.020283094,-0.036545377,-0.0018384126,-0.029698648,0.013036778,0.017541489,0.02353798,0.026544312,-0.0009250847,-0.017906355,0.07874671,-0.08060585,-0.010756786,-0.017765645,-0.03812685,-0.064825386,0.013958673,-0.08092665,0.049863614,-0.04361827,-0.018840592,0.036976125,-0.0581528,0.015686346,0.0357618,0.07314258,0.113931164,0.056671247,0.0556434,-0.062239867,-0.022219922,0.008408246,-0.02491987,-0.04682198,-0.029544665,-0.009379617,0.058600966,0.008685922,0.029720388,0.0429158,-0.009251826,-0.010780929,-0.059131023,-0.033082783,-0.118176565,-0.0030062068,-0.047958195,0.05949559,0.013766456,-0.055783443,-0.012438566,0.050786544,-0.058212515,0.1149916,0.03270012,-0.03439075,-0.05281669,0.0050029573,0.014270379,-0.06098489,-0.058608327,0.017817045,0.025784388,-0.014275199,0.07817772,-0.024144828,-0.022881929,0.08905565,-0.076869376,0.06918768,0.074238785,0.034853105,0.045611404,0.018825063,-0.039393205,-0.053211577,0.040691204,0.049326453,-2.9911313e-08,0.08742937,-0.007127037,0.02207701,-0.06456786,0.0371294,0.044818494,-0.017077113,-0.036389675,0.014261925,-0.013726241,-0.042581674,0.14556459,0.074157506,0.053611297,-0.021544054,0.033852108,-0.080581546,-0.004946004,-0.018454801,-0.09543764,-0.04138348,-0.04367235,-0.08241597,0.0563165,0.039987974,-0.042282324,0.045736667,-0.006375299,-0.024968736,0.008337797,-0.13334633,-0.006547882,-0.004821083,0.002108593,-0.016562968,0.0070812777,0.03337123,-0.013141684,-0.035443354,0.024245743,0.05745383,0.03431055,-0.064268604,-0.033026844,-0.0038227248,0.031963795,-0.033929475,0.008860736,-0.07309748,0.052078635,0.013010285,-0.02345198,0.018434357,0.023263976,-0.1412811,-0.0137993395,-0.035067353,-0.060576927,-0.0028953212,0.017197074,0.008087486,0.04468829,0.106172584,0.00425949 +2.3.1.243,"The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A. It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached at the 2-O position of the non-reducing glucosamine molecule. The enzyme from the bacterium Escherichia coli is specific for myristoyl (C14) acyl groups, giving the enzyme its previous accepted name. However, enzymes from different species accept highly variable substrates.",384,0.99999994,-0.057109553,-0.0658451,-0.10793554,-0.030881079,-0.051890433,-0.029874206,-0.022350293,0.049703702,0.07734445,-0.035204634,0.036624573,-0.023800807,-0.0104155885,0.050107375,-0.07930052,0.04301468,-0.013985701,-0.017614711,-0.053630903,-0.08663373,0.10178508,0.03705135,-0.03702699,-0.038877014,0.011577674,-0.0043231016,0.04073869,-0.031120999,-0.0051321667,-0.07139775,-0.0455429,-0.047717046,0.07574928,-0.04648188,0.08972497,0.10518372,-0.042504676,-0.06981939,0.1302476,0.035952765,0.030709704,-0.011327678,0.0022761105,0.027334189,-0.0066780234,0.012838605,-0.0096004,0.038901262,0.0059804134,0.012070708,-0.017796597,-0.044832498,-0.032936968,0.03308131,-0.03328136,0.039905615,-0.013182941,-0.026104558,-0.042125776,0.09039693,0.0427358,0.0059521645,0.037040003,0.050320953,-0.032995224,-0.100263305,0.064329945,-0.0221557,0.012634072,-0.028864907,-0.07432688,-0.03617201,0.03322448,0.021195723,0.058866315,-0.0659634,0.029595476,0.0062128394,0.033004627,-0.057546917,0.009516976,-0.07641405,0.0016203073,0.056358915,0.048725862,-0.0352303,0.052847855,-0.02822531,0.033396687,0.08367602,0.012779209,-0.074330434,-0.035200503,-0.047564078,-0.05646961,-0.036727972,0.11320832,-0.047427982,-0.03428227,-0.018842887,0.032409526,0.025634147,2.4956746e-05,-0.0050694575,-0.01873725,0.03143603,0.011446344,0.0496295,-0.05176681,-0.0127021605,-0.021151034,0.07049921,0.028671347,0.013108261,-0.03293635,0.074526995,0.020240089,-0.05389802,-0.043565102,0.00094291684,-0.007393224,-0.042945247,0.0044660093,0.05787135,-0.12425244,0.08119154,-0.03978564,2.9435466e-33,0.038313836,0.017007643,-0.04788478,-0.07106596,-0.011541108,-0.069013506,-0.08507228,-0.0076757153,-0.0665026,-0.01920822,0.011147909,-0.12763177,0.038202304,0.102606475,-0.031468328,0.020509567,-0.031293366,0.059818517,0.08246999,0.025999663,-0.005515052,0.06502028,-0.0029773766,-0.016224006,0.022349063,0.0536604,-0.05052205,-0.007269173,0.031691004,0.009190249,0.031748176,-0.076637566,-0.085964076,0.036270373,0.06332376,0.010616052,-0.015607846,-0.08959081,0.033661056,0.036113657,0.008056772,0.022232806,0.031176921,-0.021020943,0.03946677,-0.037156492,-0.087597415,0.048166513,0.015742641,0.035397038,0.0051313955,-0.015780745,0.13720207,0.007002323,-0.0359369,-0.033540417,-0.0647609,0.00034052102,0.01297904,0.017273001,0.01782616,0.109340526,-0.0882107,0.057415888,-0.00041407454,0.05095249,-0.053279415,-0.05890966,-0.0018477069,0.11198229,0.001141417,-0.03666548,0.01740898,0.0982611,0.07445176,-0.017016513,-0.05137108,-0.0030027337,-0.026771339,-0.030719759,0.017066063,0.046093147,0.0019119355,-0.059496477,-0.08511797,0.022274066,0.019486733,-0.059229057,0.010621259,-0.00042761205,-0.0074695894,-0.048342105,0.00488406,0.047135673,-0.02865766,-4.837903e-33,0.055315565,-0.09382365,0.114731885,-0.11845432,-0.08168515,0.012578747,0.0061685177,-0.02537477,0.045667235,0.03503807,0.017008876,0.054880686,-0.026123052,-0.008287939,0.009899738,0.050377097,-0.04445539,0.004034548,-0.0123977475,-0.03306125,0.0065297056,0.058207296,0.043309152,0.033295557,0.029322546,-0.0146402335,-0.06634344,0.033130124,0.009644156,0.036354017,-0.03024446,-0.05342178,-0.011230904,-0.03452696,-0.045002684,0.06996935,-0.088971,0.0032222765,0.013523342,0.02986804,0.0042990427,0.0838181,0.04026783,0.013582427,-0.016915757,0.04708787,-0.13393791,0.05072687,-0.023259671,-0.07245185,-0.06353727,0.04441932,0.07761797,-0.0043535046,0.07137249,0.073528,0.057097886,-0.05974628,-0.020741656,-0.09453681,-0.03485385,-0.06714,0.033775937,-0.0028682898,0.105040446,0.017197372,-0.012269766,0.043628242,0.033048827,-0.026483294,0.059681945,0.008201326,-0.0041284594,0.05360144,0.019261966,-0.028491473,-0.027018083,-0.05422589,-0.02607794,-0.009165752,0.01678379,0.03154896,0.04224379,-0.09900874,-0.05462238,-0.06992874,0.06166381,0.10322397,0.031437315,0.025071716,0.028081428,0.018060086,-0.06823382,0.021484604,0.06576072,-4.33772e-08,0.08408156,-0.044796478,0.10321334,-0.053260293,-0.016013552,0.043077935,-0.026478918,-0.020514037,0.05655723,0.016290002,-0.08324473,0.11041948,0.078090765,-0.063545376,-0.024411986,0.06405759,-0.075721346,-0.034057774,0.0015257936,-0.065935574,-0.0499527,-0.011916615,-0.090084225,0.040710844,0.08390672,-0.04038551,-0.008166956,0.042525582,-0.07932274,0.0029870817,0.0019310175,0.032453485,0.010584584,-0.023693915,-0.020217558,0.013819462,-0.050087698,-0.049854264,-0.059876744,0.07722595,0.035407368,-0.031204036,-0.027263978,0.043938026,0.035668552,0.011667324,-0.0050513516,-0.035505787,0.009056306,0.054216567,0.006909457,-0.026186714,0.018516993,-0.02108278,-0.08117682,-0.027499452,-0.080020286,-0.008498296,0.0016317955,-0.041987635,0.023838947,0.09819892,0.1768375,-0.04886428 +2.4.1.332,The enzyme has been isolated from the bacterium Bacillus selenitireducens. In the absence of glycerol the enzyme produces alpha-D-glucopyranose and phosphate from beta-D-glucopyranose 1-phosphate. In this reaction the glucosyl residue is transferred to a water molecule with an inversion of the anomeric conformation.,384,1.0,-0.087981276,-0.047420677,-0.07764564,0.006943648,-0.037622295,-0.0070865517,-0.04746332,0.057514194,0.044823423,-0.042439234,0.05632838,0.009062476,0.014095721,0.052594155,-0.111092225,-0.03024989,-0.033995662,0.022460112,-0.03427749,-0.028635861,0.023787284,0.05043489,-0.053851787,-0.015341102,0.051366102,-0.028411107,0.08229968,-0.079883315,-0.030824784,-0.031533066,-0.014447912,-0.13593076,0.11943635,-0.037276223,0.100650236,0.049508087,0.0009266318,-0.0058101667,0.10602612,0.022615762,0.0061559645,-0.00520718,-0.030193647,-0.010277905,-0.08955674,0.012053216,0.011555641,0.04530435,0.034893174,0.039674494,-0.00641845,-0.0818061,-0.08135006,-0.036282033,-0.013050062,-0.045773026,-0.007983027,0.013774004,-0.0005018966,0.031038897,0.057444483,0.028954463,0.010434851,0.04006188,-0.046398524,-0.082306266,0.07289563,-0.058297087,-0.010434741,-0.047370687,-0.029544685,-0.037099518,0.054196257,-0.044192698,0.03913579,-0.029799702,-0.053819206,-0.04173619,0.052098915,0.018035732,0.08389684,-0.084907606,0.036637526,0.109735854,-0.032342225,0.030378293,0.008470405,0.021699687,0.024712455,-0.021144697,0.029038444,-0.04676796,-0.03844336,-0.11092272,-0.017787725,0.003380988,-0.008516347,-0.015014059,0.039219413,-0.022447662,-0.05568611,0.055432573,0.04768303,-0.0387104,-0.047974315,0.056370813,-0.012713259,0.047319997,0.11098708,-0.012421661,-0.01971214,0.09329832,0.0749834,0.019284673,-0.046542242,0.02562998,0.0077412296,-0.023553153,-0.071266234,0.025069576,0.057188194,-0.046170954,0.024555184,0.06602633,-0.025249263,0.09823652,-0.012934098,2.7209087e-33,0.060165133,0.05233541,0.034548517,-0.03797924,-0.022153491,-0.038556013,-0.051946104,-0.03405077,-0.11089363,-0.04277497,-0.06506163,-0.09772736,-0.005080031,0.10695586,-0.05116573,0.053417597,0.048348133,0.00828873,0.08104422,-0.029218651,0.055750433,0.0024764382,-0.02797083,0.00560852,0.06318744,0.02612561,-0.03349344,0.10431347,0.08533286,-0.031803418,0.052359022,-0.09272678,-0.06684273,0.017207125,0.05355117,0.031174108,-0.05720607,-0.0064701787,0.022144593,0.02145429,0.015423187,0.014551374,0.008881566,-0.07644862,0.07979224,0.01018852,-0.024497043,0.06387335,0.075650476,0.066405654,0.015023182,-0.010547773,0.04089438,-0.01537843,-0.009006567,0.036861993,-0.013997374,0.0019679195,0.023192119,0.063179374,0.06758362,0.09803882,-0.03966406,-0.039762568,0.060396925,0.020418303,-0.05382848,-0.0088198045,-0.018221693,0.00093747576,-0.056050364,0.033931643,-0.010462206,0.058622796,-0.05414931,-0.04615524,0.00741024,-0.036058363,0.014059457,-0.07541198,-0.043417174,0.021995123,0.0228617,-0.039071325,-0.09606497,0.0022020256,-0.01845149,-0.053403493,-0.027769651,0.03840936,-0.007287227,-0.09579557,-0.12733357,0.022221684,-0.03399709,-3.5445416e-33,0.09832894,-0.11661794,0.06689497,-0.04067847,-0.06718856,0.018753815,0.06159868,0.04915344,0.016197983,0.027332602,-0.0070606796,0.0495013,-0.018847229,-0.039883167,0.0032474028,0.05144581,0.039843403,0.061353184,-0.025262635,0.0056154495,0.011270474,0.05310306,0.06712731,-0.012200186,0.018612811,-0.016789014,0.028573358,0.04265691,-0.015347303,0.05824004,0.019344361,0.009608898,-0.0059452225,-0.079089776,-0.09111845,0.07968896,-0.086007625,-0.033253536,0.04368641,-0.004555521,0.0028360565,0.054433785,-0.0067364722,0.022670861,0.093769096,0.0933442,-0.03206417,0.022962652,-0.018645074,-0.08838255,-0.02981206,0.024091527,0.034552235,0.011080492,0.0586756,0.04127459,0.032073397,0.027518336,-0.06285357,-0.107132986,-0.023219718,-0.054273814,0.004374033,-0.021368094,0.056271017,0.11460781,0.02053546,0.05673682,0.025563862,-0.028461372,0.0017502599,-0.04936239,-0.00518489,0.03855241,0.0014103687,-0.045498203,-0.12819025,-0.0370761,-0.03788628,0.003525657,0.029392919,0.037333358,-0.02330052,-0.042021226,0.05909641,-0.06181368,0.029092299,0.0685915,0.055571765,0.04306438,-0.054570906,0.017738221,-0.012811599,0.028179059,0.11968557,-3.7554784e-08,0.05941401,-0.0332526,0.07609604,-0.07287957,-0.009554055,0.0017115497,0.024843516,-0.004999971,-0.032626506,0.0047766245,-0.14023806,0.025035122,-0.054559153,-0.022710778,0.015622578,0.06113839,-0.042444084,-0.021675969,-0.034470387,-0.0066277753,-0.087053895,0.037699673,-0.090730004,0.06022407,0.029325191,-0.059077274,0.026979366,-0.008505604,-0.054449987,0.029861366,-0.0052882815,0.027708998,-0.038256127,-0.08339307,-0.053146113,-0.027480157,-0.08822789,0.048636634,0.024749218,0.033956904,0.035623707,0.02073851,-0.033967722,0.021224823,-0.01370895,0.032536846,-0.051783275,0.0073684813,-0.004876744,0.04168472,0.06161008,-0.06038412,-0.050604355,-0.026624965,-0.11085556,-0.021660294,-0.01424368,-0.05327414,-0.008657232,-0.02746156,-0.0035607333,0.0025627213,0.1640378,-0.010077855 +2.4.1.333,The enzyme has been isolated from the bacterium Listeria innocua. It catalyses the reversible phosphorolysis of beta-(1->2)-D-glucans. The minimum length of the substrate for the phosphorolytic reaction is 3 D-glucose units. In the synthetic reaction starting from sophorose and alpha-D-glucose 1-phosphate the average polymerisation degree is 39.,384,1.0,-0.03531688,-0.028204989,-0.080618136,-0.029476801,-0.008774243,0.0114156995,-0.018253705,0.08018654,0.034164447,0.04659067,0.024672639,0.03155577,-0.10063697,0.07089211,-0.10064881,-0.036515888,-0.024773205,-0.0034143142,-0.021519726,-0.010330221,0.1234051,0.0011853233,0.032573238,-0.013078076,0.07261067,0.013306738,0.06675862,-0.047624785,-0.037683725,-0.0462639,-0.037725326,-0.06332139,0.10994458,-0.07263689,0.06553183,0.061218686,0.05957369,-0.05374066,0.06337654,0.024098132,0.027177816,-0.0020824985,0.028937731,-0.027027022,-0.0103939315,0.031524647,-0.10248389,0.10363485,0.081854895,-0.060176853,-0.0553318,-0.028429471,-0.048805494,-0.027535178,0.027051954,-0.0067909053,-0.044109616,0.02187663,0.024404272,0.053420506,0.03554884,-0.013490816,0.0074404264,0.052851066,-0.03062297,-0.0734908,0.028045828,-0.08558063,-0.030737594,0.048929866,-0.03889046,-0.024821635,-0.028600914,-0.022602374,0.10668009,-0.02537284,-0.017109308,-0.027856719,0.023017952,-0.010729211,0.082693934,-0.028595567,0.03252037,0.049010996,-0.048264075,0.015944341,-0.026175523,0.048980355,0.08701175,0.042000975,0.014655912,-0.048084196,-0.022313217,-0.12074682,0.035622682,0.026035704,-0.009574243,-0.019025033,0.06318577,-0.029747939,-0.029417869,-0.027271787,0.04281505,-0.084426805,-0.024930056,0.095182374,-0.0042900536,0.07610071,0.033640083,0.048640445,0.0041591222,0.066892035,0.030904131,-0.014360257,-0.086087584,0.04906,0.07938932,-0.088599205,-0.08427367,0.019102998,0.026363116,-0.060960297,-0.0021927785,0.025210172,-0.089267544,0.09027522,-0.045840282,2.9772783e-34,0.037660528,0.059798174,0.037869688,-0.11057887,0.004211995,-0.005141346,-0.015160442,-0.055756383,-0.038600642,-0.060342643,-0.018767238,-0.057837777,-0.040785577,0.041418564,0.030092075,0.041014712,0.0786816,0.08902377,0.018450584,-0.036026366,0.02737715,0.0056057894,-0.031002695,0.0069890693,0.07246641,0.039508335,-0.029028289,0.011547493,0.029968435,-0.019844757,0.055148583,-0.009001757,-0.0634662,0.025030784,0.031892337,-0.0010544527,-0.102364436,-0.04461281,0.059414692,-0.020354195,0.039950516,0.032155145,0.032647543,0.023333909,-0.017648576,0.0047177267,-0.014171061,0.02961236,0.033986446,0.060590904,0.008095831,0.03499448,-0.023150504,-0.015048684,-0.003910508,0.055147156,-0.005783484,-0.046675634,0.046315942,0.027042272,-0.050711315,0.122121595,0.013601821,0.014708837,-0.0399241,-0.065835774,-0.06417444,-0.038657837,-0.07422665,0.037991278,-0.026603958,-0.07777612,0.005737501,-0.013411685,-0.043155372,-0.027081551,0.021974057,-0.050475076,0.026608363,-0.030321069,0.036480285,0.022809759,-0.027543005,-0.044461973,-0.10915774,0.014090266,-0.020870933,-0.053065334,-0.021521054,0.074224055,-0.03619675,-0.10927005,-0.08099876,0.021293519,-0.036406957,-2.1432963e-33,0.08407217,-0.09238998,0.07145163,-0.072295874,-0.08271188,0.037822116,0.024763087,0.053580295,0.045697328,0.0113906525,0.001147477,0.04072857,0.0042944704,-0.04325081,-0.020717915,0.056170285,0.06676663,0.08547654,-0.05051026,-0.04877063,0.013813047,0.04318216,0.07520196,0.02352562,0.012114417,-0.029526163,0.0101764845,0.060166303,0.0016253019,0.035421144,-0.014265117,-0.044672195,-0.04697875,-0.009808502,-0.014403306,-0.005999847,-0.021786299,0.0016758615,0.08375493,-0.018917916,0.043256488,0.013668576,-0.001852226,0.0032710636,0.0770503,0.08520542,-0.015694346,-0.007075395,0.007166283,-0.034313586,-0.029810026,0.059481744,-0.010660478,0.0512107,0.020720795,0.031209735,0.00060958473,0.020821499,-0.08329471,-0.08966148,-0.028759228,-0.08318048,0.04484656,-0.036650945,0.10173276,0.07581076,0.027471052,0.05937449,-0.030001108,-0.03713541,0.03759172,0.043285504,0.03269085,0.04675388,-0.060325444,-0.08602114,-0.07807504,-0.061775096,-0.008869898,-0.02043718,0.032230757,0.05825156,-0.025737422,-0.04740659,0.069432415,-0.112514324,0.12331528,0.12319484,0.0073085055,0.09297627,-0.027050752,0.0010617191,0.0038559055,0.044541545,0.093941174,-3.7485492e-08,0.060189024,-0.0359073,0.02141503,-0.052013908,-0.048859205,0.011962632,-0.031887755,-0.044328842,0.030634914,-0.044944957,-0.07369895,0.08913252,-0.0227709,0.0227102,0.03586852,0.0063578924,-0.12313823,-0.035847154,-0.011919402,-0.03110952,-0.047350038,0.031449553,-0.10161027,0.008730247,-0.057090677,-0.0011670598,0.0922186,-0.004394601,-0.05043234,0.0037810346,-0.02121778,0.060125314,-0.077021174,0.00013644017,-0.054045737,-0.07851178,-0.0636594,0.034975965,-0.021728225,0.016666932,0.007068848,0.010577529,-0.010334315,0.06747688,-0.059322704,0.0312189,-0.018140921,0.0275847,0.010726092,0.04713982,0.07204232,0.01722137,-0.067557245,-0.062476616,-0.102322966,-0.008931876,-0.016062133,-0.050910257,-0.025385056,-0.029837755,0.030543434,-0.025237128,0.15805894,0.028494481 +2.4.1.334,"The enzyme, isolated from the bacterium Clostridium phytofermentans, catalyses a reversible reaction. Substrates for the phosphorolytic reaction are alpha-1,3-linked oligoglucans with a polymerisation degree of 3 or more. Nigerose (i.e. 3-O-alpha-D-glucopyranosyl-D-glucopyranose) is not phosphorylyzed but can serve as substrate in the reverse direction (cf. EC 2.4.1.279, nigerose phosphorylase).",384,0.99999994,-0.022156827,-0.0328459,-0.087665014,0.0248379,0.05431401,0.0011856632,-0.012303956,-0.028542604,0.046315838,0.022308834,-0.030503962,0.038283937,-0.07742686,0.07405036,-0.08771082,-0.009541155,-0.008370385,0.0034231665,0.05455896,0.038605016,0.0769748,0.0069752387,0.029831884,0.027345886,0.071927324,-0.03583329,0.06405481,-0.07555046,-0.021714069,-0.07552219,0.023539875,-0.09017433,0.01801118,0.017076561,0.06154764,0.07227607,-0.014833332,-0.057337258,0.06862685,0.01815398,0.03780709,0.0007914596,-0.03788787,-0.040995687,-0.08927441,0.017900227,-0.05907832,0.057431705,0.03932098,-0.03252806,-0.018315662,-0.07950709,-0.09724204,-0.008944313,0.040127523,0.03194209,-0.058385946,-0.007672136,0.0009023338,0.04213894,0.021396058,0.012217745,-0.0057169395,0.038169242,0.004855592,-0.053491615,0.056082398,-0.061127678,0.004317194,0.0006136754,0.020704549,-0.01550989,0.02598576,-0.05334019,0.085288584,0.04786919,0.0035118952,-0.010871026,-0.01087276,-0.019193357,0.043452885,-0.029039815,0.037668742,0.056302432,-0.022854747,-0.028852899,-0.023617897,0.03856198,0.095571,-0.015697373,0.03967444,0.023355901,0.06329863,-0.07698171,0.013998986,0.0014429785,0.010677554,0.015114334,0.028011573,-0.020515453,-0.025873644,0.012015796,0.07582945,-0.054444302,-0.087241724,0.060637295,-0.008269903,0.086537614,0.011934673,-0.0009638519,-0.015570067,0.064703576,0.120476745,0.04366231,-0.068928,0.0037011316,-0.016674891,-0.093821086,-0.04303872,0.01692868,0.022304697,-0.023552027,0.028848559,0.03845909,-0.08989678,0.08767052,-0.018262355,2.5973323e-33,0.06346849,0.07499778,-0.0023549353,-0.1251889,0.018571334,0.015419426,-0.047878765,-0.02967977,-0.063176244,-0.047358178,-0.015135025,-0.023932643,0.0075081247,0.10143639,0.007246611,0.006817444,0.02737021,0.11276811,0.058855698,0.0027503602,-0.00021542537,0.034038987,-0.03322528,-0.019494578,0.058093,0.01641454,-0.08901666,0.040914286,-0.00614104,-0.032146763,0.1189756,-0.031912543,-0.06611482,0.011219638,-0.0049260673,-0.041765213,-0.0869709,-0.09515554,-0.030642536,0.012976184,-0.0027460535,0.02635308,-0.029312117,0.0057042614,0.05508308,-0.004726079,-0.026682759,0.08402631,-0.031685356,0.07827104,-0.013521465,-0.010899318,0.028800424,-0.04226209,-0.0008350912,0.04247232,-0.012779054,-0.05298968,0.108224705,-0.0053995554,0.014876136,0.116330616,-0.050233286,-0.04744582,-0.009109746,-0.017728332,-0.033116654,-0.023467796,0.0034030804,0.03236632,-0.019778766,-0.042882487,-0.070398375,0.042387724,0.013862456,-0.080780126,-0.015749732,-0.08728186,0.024932822,0.014951647,0.0070912754,-0.0088319415,-0.030134287,-0.006858169,-0.06655866,0.0038159825,-0.07338111,-0.027703932,-0.057320546,0.06534944,-0.05754447,-0.10929839,-0.08349907,0.055575076,-0.012452929,-4.0959348e-33,0.14260866,-0.0999434,0.03675415,-0.036436975,-0.075586505,0.034062438,0.022410316,0.0076239863,0.023173993,-0.02472066,0.027049057,0.017848598,0.024253488,-0.03331332,0.0071660117,-0.014869991,0.011422082,0.08851654,-0.049536947,-0.004267642,-0.023783773,0.09324168,0.040425945,0.03709426,0.091038465,-0.026252069,0.0038899854,0.101551026,0.011447556,0.0406831,0.014364245,0.027460573,0.0057231127,-0.023551492,-0.013329211,0.06267832,-0.025368445,-0.05165387,0.033901326,0.001993046,0.059695344,0.07874365,-0.021785289,-0.0036630519,0.0046087345,0.082966834,-0.08022619,0.04621621,0.038862333,-0.050966434,-0.047217842,0.07011226,-0.009868339,-0.0106792785,0.06849347,0.02378694,0.039495964,-0.024587614,-0.016002972,-0.10678645,-0.053799808,-0.05801106,0.07660372,-0.023986451,0.0853131,0.08989453,-0.027239488,0.06304168,0.047070157,-0.03445641,-0.0057071946,0.0052186497,0.0045557595,0.018170757,-0.04139346,0.0334074,-0.10535859,-0.040107217,0.008933958,-0.021394385,0.054747194,-0.03344628,0.057835992,-0.05345729,0.018432068,-0.06432411,0.02673287,0.08965699,0.038884893,0.090971656,-0.022184014,-0.12887539,0.0038274566,0.05527042,0.07817638,-4.4114717e-08,0.034599233,-0.027529733,0.09137517,-0.08240654,-0.030049073,0.009631292,0.010205783,-0.032471646,-0.040158447,-0.0367876,-0.023999905,0.04967469,0.012944525,0.041114856,0.034507032,0.028706841,-0.06112576,-0.0313973,-0.016504323,0.0031764586,-0.06928966,-0.048010584,-0.121526524,0.08460364,0.033967502,-0.044556357,0.03460087,0.019717854,-0.056954157,0.023592338,0.012321258,0.02305924,-0.014679225,0.003706384,-0.0024284713,-0.04008871,-0.07292992,-0.016882503,-0.033786383,-0.018541899,0.009847737,0.016320217,-0.03843276,-0.0025616325,-0.04569202,-0.023445088,0.009298641,0.010481248,-0.07958333,0.005800296,0.08885555,-0.079587854,-0.08384364,-0.034860075,-0.056167006,-0.101436414,-0.011642646,-0.06357853,-0.068656035,-0.03157457,0.052129947,0.0031533197,0.22230278,-0.04913745 +2.5.1.128,"The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N4-bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. When spermine is used as substrate, the enzyme forms N4-aminopropylspermine. ",384,1.0,-0.033842057,-0.02255409,-0.1358593,-0.03904045,-0.0021855547,0.059216492,-0.020681899,0.013145564,0.03032732,0.09017715,-0.009070531,-0.03878965,-0.014023466,0.13335459,-0.04766493,0.029489692,-0.05699739,-0.0314047,0.062808566,-0.017743083,0.07306141,0.004498663,-0.036103375,-0.010344459,0.03079363,-0.02764596,0.028133184,-0.008766418,-0.026616707,0.0531011,-0.019090079,0.02233237,0.071763165,-0.041216686,0.045606513,0.051518254,-0.03428951,-0.0064794496,0.065632075,0.06929652,0.101178735,0.034904853,0.049392466,-0.026303122,-0.018466402,0.051734313,0.058523856,-0.0068246606,0.10186338,-0.012146431,-0.04183663,-0.057323266,0.051012915,-0.0024923107,0.034240052,0.027817626,-0.046088923,-0.060675964,0.0046536266,0.044173323,0.043800697,0.05093359,-0.024154969,0.0060473178,0.07250804,-0.023051813,-0.008430565,-0.009786953,0.02084547,-0.01903688,-0.051693864,0.02073869,0.022438314,0.054176345,0.008753292,-0.0514439,0.018202988,-0.047133587,0.06363805,-0.03516456,-0.05362273,-0.063444175,-0.049608637,0.023127014,0.010776034,0.07209875,0.13969246,-0.023687633,0.0946198,0.0033529133,-0.046658985,-0.0021457584,-0.032957856,-0.10015129,-0.10242199,-0.03029269,-0.027082074,-0.004311649,0.026217395,-0.0139179565,0.024230067,-0.0007343475,0.0025049173,-0.101208664,-0.025822232,-0.009104598,-0.018277993,0.07012847,0.05624212,0.046784986,-0.029504888,0.0054177865,0.032241754,0.044421922,0.008818451,0.03249694,-0.056389213,-0.06853518,-0.079002135,0.03504467,-0.043669477,0.0028196622,0.015191693,0.08490439,-0.116932616,0.0523559,-0.047842182,2.3592016e-33,0.07078732,0.022940813,0.06682655,0.052810833,0.046572246,0.034126844,-0.0280613,-0.045964085,-0.005794906,-0.16406119,-0.0012359543,-0.025688183,0.06436481,0.07877941,0.0030395582,-0.03392583,-0.03459993,-0.015744856,0.06155487,0.067241214,-0.05333569,0.09530948,0.010864059,0.04932737,0.042714234,0.013187922,0.014831221,0.011641513,0.04605414,-0.011361349,-0.017250152,-0.06621048,-0.14190342,-0.015002135,0.06320967,-0.00065422815,-0.041861553,-0.05430016,0.00016650939,0.055921737,0.020462433,-0.019768834,0.051100507,0.01840022,-0.024022743,-0.0017586012,-0.03426888,0.09478666,-0.017337522,0.051470052,0.034135852,0.037003715,0.05809128,-0.055452105,-0.10921181,0.037554193,-0.05849844,-0.07114014,0.02318525,-0.03400658,-0.011178298,-0.032030754,-0.07483927,0.0749628,-0.029199839,0.0074439156,-0.003208473,-0.06172064,0.04096737,0.02707427,-0.061858345,-0.018578796,0.035320517,-0.0059399437,0.014081918,-0.009291413,-0.116928436,-0.024640987,0.037915647,-0.05715229,-0.042368725,0.01852469,-0.016322082,-0.016579095,-0.06149883,-0.05283369,0.060342375,0.019058822,-0.0040149274,0.043385718,0.0049378243,-0.18718505,-0.010361417,0.040588252,0.0063879723,-3.3697867e-33,0.07420177,-0.111731045,0.007319589,0.008493518,-0.0672664,0.015402777,0.10494419,-0.044039376,-0.0776713,-0.057784546,0.123944424,-0.023332123,0.089742176,-0.018137516,0.059161097,0.016111124,-0.00576325,0.05519857,0.02896805,-0.019495422,0.013744612,0.032595813,-0.029918058,-0.039050393,0.011938773,-0.009485525,-0.028614992,0.03729559,0.05422222,0.04345502,-0.058779564,0.030180402,-0.065232,-0.004444561,-0.008171447,0.025652904,0.027605856,0.0025250101,0.06357613,-0.05127614,0.00095347984,0.06360019,-0.023531957,0.07149462,-0.01608671,0.056931663,-0.02790837,0.06109991,0.04065306,0.06634815,0.02443943,-0.061474755,-0.0464706,-0.07415917,-0.051809933,-0.028785966,-0.03911848,0.0016243143,-0.01895252,-0.0282735,-0.09848055,-0.09284979,0.07726339,0.048368007,-0.058669943,0.050952416,-0.078213744,0.0855473,0.016070046,-0.04473012,0.0939925,0.0077755866,0.11480014,0.0044665993,-0.023699883,-0.083670676,-0.035498086,-0.0058439826,0.018611623,0.0056410115,-0.0400489,0.0034844356,0.014276489,0.017566558,0.0007950353,-0.03564671,0.11744981,0.022279402,-0.011488145,0.014755262,0.012698148,-0.03190879,-0.024550382,0.05855929,0.07417848,-3.5604717e-08,0.037359834,-0.0034797024,0.10836476,-0.06958022,-0.0037771272,0.012132493,-0.010216792,-0.03136619,0.073477656,-0.10179545,0.010339654,0.074817315,0.022603253,0.05620264,-0.004814346,0.02552563,-0.06333288,-0.008988505,-0.03539318,-0.060593046,-0.10341499,-0.07446362,-0.10759679,0.07230493,-0.0050017717,0.025275588,-0.01938303,-0.014380106,0.00466164,-0.06162567,-0.040147707,0.012036891,-0.05699401,-0.052939225,-0.030144583,0.03170895,-0.010618145,0.0005241562,0.011519555,0.013402085,0.06008418,-0.044327796,-0.02799971,0.021005996,0.04825717,-0.03590401,-0.025451008,0.0140190665,-0.037232738,0.038468096,-0.0039516683,0.03779274,0.0023547835,-0.039175816,-0.08926835,-0.035265382,-0.04219998,-0.053228557,-0.03141245,0.03244325,-0.036453623,0.03315412,0.12340829,0.019729456 +3.1.1.97,The protein is only present in eukaryotes.,384,1.0,-0.009955922,-0.007894568,-0.08492097,-0.006440032,0.061160367,0.018645952,-0.025316218,0.003305779,0.06055351,-0.006022545,0.062061053,-0.074418515,-0.096759096,0.019994102,-0.0079119485,0.0004311612,-0.022450304,-0.0379104,0.02407083,-0.06892592,0.025630264,0.054598182,-0.010431838,0.0044165584,-0.014170516,-0.025198888,0.022668928,0.008422271,0.0052092583,-0.092045374,-0.06854154,-0.06595218,0.009315884,0.03950864,0.065296896,0.021270242,0.010185445,-0.09331373,0.03424665,-0.089397885,0.062942095,0.030907234,-0.024858808,0.013090152,0.056776352,0.090947725,0.037902206,-0.019782253,0.04200603,0.0026712376,-0.030274963,-0.052297175,-0.049184073,0.042798847,-0.015506861,0.0022990273,-0.0354233,0.0058574714,0.026678573,-0.05184112,-0.046340767,0.008552434,0.07539831,0.02233679,0.05800829,-0.09978335,-0.021364952,0.028345507,-0.0545104,0.03171993,0.04619172,-0.040395055,0.033886805,0.12119608,-0.017741697,0.011858605,-0.0747613,-0.050479293,0.040603757,0.07447602,-0.014581117,-0.0063539473,0.079478905,0.055605363,-0.019410083,-0.020833736,0.004916359,0.035610527,-0.06918412,-0.0068313833,0.041597307,0.013189686,0.0125057995,-0.045182753,-0.022303639,-0.03859506,0.051255036,0.050215453,-0.013897522,-0.045853384,0.008236533,-0.0075617754,0.12676218,0.015236733,-0.0252708,0.00983349,-0.011739607,0.027980324,0.0052237557,0.016543828,-0.0105486205,0.013057193,0.07019388,-0.06986623,-0.017358204,-0.046219174,0.029840115,-0.02473345,-0.07000105,0.06195444,-0.05915542,0.017075079,0.078542404,0.103744954,-0.05752353,0.018485364,-0.11244354,-2.7921705e-33,0.032604992,-0.06489669,0.02646402,-0.04823346,-0.04411924,0.015517155,0.013740223,-0.025527777,0.036799353,-0.03154661,-0.09244604,-0.054665547,0.121306546,-0.012490779,-0.003160724,0.10171549,0.040014222,-0.0012378531,0.059660167,0.047356714,-0.04858438,0.06346226,0.0058541414,-0.044028416,-0.0049513187,-0.039621178,0.017362311,-0.103132635,-0.013078023,-0.0011508594,-0.11384498,-0.034808315,-0.10033087,0.087256365,0.07393457,0.0048345155,0.07066965,-0.071390316,-0.06432875,-0.028223872,0.050359756,-0.028794399,-0.02236912,-0.115201056,0.05949525,-0.03976053,-0.019750196,0.021687225,-0.065163404,-0.027997028,0.0497124,-0.032954983,0.057830967,-0.022986041,-0.04005899,0.017222805,-0.009842092,-0.0075070877,-0.022973109,0.046263155,-0.021469621,-0.0016404049,-0.06665691,0.06083024,0.014482781,0.05081635,-0.13092932,-0.09818434,0.001223674,0.0013511815,-0.028455004,-0.07518735,0.098627426,-0.046636425,-0.03024793,-0.08689276,-0.029165536,0.021293972,-0.000294432,0.10081188,0.011316373,-0.08137679,-0.03403821,-0.0056342753,0.021079889,0.031190494,0.055999402,0.03167514,0.025983073,-0.0054547423,0.0897151,-0.067964524,-0.082685255,0.013266965,-0.0032128552,-1.6114823e-34,0.031362783,-0.05743874,-0.0047447886,-0.028220288,-0.053134393,0.11861284,0.056593474,-0.005919337,0.019238608,-0.021932,0.15527654,-0.04804528,-0.03191992,-0.019100914,0.027428208,0.10757499,-0.105574645,0.08071238,-0.015246013,0.0352411,-0.05242887,0.04755384,-0.013079264,0.089199245,0.0048635486,0.010449495,-0.027484199,0.06909515,-0.038372993,0.015124703,-0.030760791,0.024147836,-0.11997332,-0.1103328,-0.040300533,-0.08862793,-0.020008009,-0.039588746,0.03886108,0.0070474423,0.038951103,0.063942485,-0.01114749,0.064966954,0.033102863,0.022907304,0.03235627,0.00916669,-0.023262372,-0.032379404,0.046314426,-0.04266045,0.016431948,-0.0707995,-0.024793258,0.020537348,-0.0067003635,0.050582156,0.00090277503,0.03923527,0.0088965595,-0.054200184,0.0012661009,0.013479477,0.041964635,0.07383339,-0.029185856,0.07767985,-0.014721361,-0.032036282,0.08764083,0.057304576,0.050857835,0.020562422,0.043189477,0.06574065,-0.06493777,-0.014514298,0.054855887,-0.06418078,-0.058424924,-0.0056190705,0.0024151255,-0.058551192,0.10022816,-0.047125723,0.020552834,-0.033464022,-0.034784906,0.024639899,-0.042285524,-0.08516543,0.020852994,0.079981074,0.042996325,-1.7643226e-08,0.0633546,0.039187945,0.024549639,-0.056608498,-0.013453765,0.07324689,0.06433826,-0.015770309,0.04202217,0.08697754,0.03496886,0.022898285,-0.064163625,0.054959115,0.025638085,0.0738879,0.0074298223,-0.028115982,-0.00423319,0.012877293,-0.03429151,0.025018064,-0.06927326,0.053633306,-0.030455235,-0.060733486,0.077405736,-0.018601801,0.07416028,-0.1028002,-0.08833898,-0.0036268139,-0.03965478,-0.013187885,-0.035491873,0.023399241,0.047098655,-0.010071946,-0.054974083,0.044155568,-0.039811447,0.015474473,-0.06951669,-0.05098675,0.011851381,0.037668265,0.012848936,0.013579154,-0.08316904,-0.010923252,0.03722915,0.036275715,-0.009247304,-0.01688927,-0.07928919,0.02459546,0.031561833,-0.032072484,-0.03761355,0.023481216,0.0006422391,-0.006694122,0.16100612,-0.01561345 +3.1.3.96,Requires Mg2+ for activity.,384,1.0,-0.060790077,-0.05960818,0.06589377,0.025950506,0.018331017,-0.079263404,0.061365385,0.015990194,-0.06144127,0.03116765,-0.007677045,0.016300902,0.018964745,0.047117166,0.09703121,-0.0022578633,0.07970149,0.05329479,0.02340152,0.03721413,0.09611903,-0.034432918,0.06627953,0.0071463482,-0.023372581,0.057631455,-0.019427558,-0.014400437,0.07025708,-0.0104233995,0.009573419,0.054991324,0.08037698,-0.059439946,-0.04362916,0.067596085,-0.0136954505,0.0075166733,-0.092280746,-0.07094738,-0.0149473315,-0.046715602,0.07469269,-0.0059906486,0.040474005,-0.09520747,0.061074156,-0.106486775,0.059206817,0.0668154,-0.023336597,-0.0387117,-0.046784703,0.026113793,0.026994562,0.01564008,-0.11781437,0.022217566,-0.0062410235,0.022554787,-0.04108908,-0.026231876,-0.053445384,0.026524452,0.06058778,0.06590911,0.0454534,-0.07451168,0.022208873,0.00017079707,-0.012213516,-0.031215033,-0.008536567,-0.021984685,-0.06149867,0.013690624,0.034637626,-0.09154157,0.06656534,0.0037888254,-0.03434827,-0.016332863,0.03747744,0.080097,0.062395312,0.025384326,0.030066242,0.010601766,-0.031048525,0.05969741,0.06153535,0.052400324,0.029620638,0.06294733,-0.013354378,0.002077971,-0.11711153,0.0039812094,-0.06477191,0.050145395,-0.028145898,0.049771123,-0.037076335,0.05172549,-0.036933098,-0.025267024,0.02390069,-0.032861453,-0.012979366,0.07779052,0.06427688,-0.034115884,0.030582765,0.041521266,-0.0062323306,0.07245949,-0.03959666,-0.048715375,0.004187488,0.028155038,0.018543465,-0.030824356,-0.012990507,-0.022339359,-0.050811328,-0.03165901,0.03027758,-2.0637453e-33,-0.0053508016,-0.0197835,0.071408,0.050433725,-0.063727655,0.040408738,-0.07832165,-0.0417292,0.037224203,-0.048125207,-0.07391685,-0.005648808,-0.045858886,0.10248045,0.05842552,-0.08516803,0.05751184,0.012287835,0.13700674,0.015277692,0.02997533,-0.021483501,-0.010012857,-0.026880657,0.009206558,0.17837198,0.082225494,-0.06813276,0.07635362,0.027991062,0.012448565,-0.11149579,-0.030480294,0.022800315,0.01646083,0.06308423,-0.052112512,-0.046288136,-0.0008042059,-0.018704228,-0.06508811,0.045802448,-0.07584181,-0.006930916,0.04689446,-0.09165215,0.057161096,0.012002658,-0.033102963,0.055371538,0.0642887,0.03727322,-0.02156047,0.023536824,-0.043999173,0.044765215,0.013470396,0.034324728,0.08825868,0.07401302,0.0076112263,0.013177398,0.09110007,0.047731705,0.03911454,0.054985527,-0.09773124,-0.048735965,-0.046318498,0.02406073,-0.0055457745,-0.05691338,0.092528395,0.03324215,0.028597841,0.0009887328,-0.008272652,-0.030911312,-0.005269611,0.016616536,-0.060429107,-0.092700906,-0.0004873265,0.020429714,-0.06318938,-0.023279816,-0.007002953,-0.06362018,-0.0394266,-0.008020647,0.010152225,-0.039577264,-0.054881472,0.04639239,-0.022701195,1.483864e-33,-0.04912281,-0.0214795,-0.008231579,-0.010753594,-0.023654386,0.033242058,0.022361038,-0.14278644,0.032284737,0.07845521,0.03712812,0.031232292,-0.045562953,-0.062041976,0.051909804,-0.055861853,-0.032928433,0.038101777,-0.013590829,-0.008670128,0.033317678,0.12016287,0.022404645,0.041800823,0.03337177,0.05347675,0.015493491,-0.0019724788,0.0414988,0.037192315,0.047791217,0.08024261,-0.10704589,-0.082046896,-0.04802206,0.030799506,0.021402523,0.009556856,-0.093700975,-0.013893651,0.0343629,0.07431838,0.05944028,0.10196152,-0.008598897,0.023211202,0.055077255,-0.004433255,0.016091647,-0.021730807,0.023474373,-0.04812101,-0.07550035,-0.078594,0.04172412,-0.008541541,-0.033007704,-0.061791506,-0.017096959,-0.075885035,0.06992493,-0.029262861,-0.021871684,-0.086994685,-0.005904143,0.044553824,0.04126407,0.061756372,0.0011206452,0.06849599,0.02756689,0.039894782,0.08222994,-0.034087125,-0.036098007,0.0973054,-0.024729343,-0.044662625,0.051950186,-0.14311704,-0.04167455,-0.0014784962,-0.011616141,-0.06057205,-0.0028408398,-0.116224,-0.043837365,0.04181758,-0.0118485,0.023558624,-0.049966738,-0.019522585,-0.014123883,0.08152368,-0.049955036,-1.5596209e-08,-0.032438,0.008350817,0.06394643,-0.011276234,0.002076065,0.03788979,-0.017993338,-0.0023198614,0.07000531,0.03785883,0.05812419,-0.03889634,0.0116652595,0.008817594,0.035463385,0.022386644,0.007971011,0.01745687,-0.10230079,-0.06774167,-0.055057954,-0.08878699,-0.061989997,0.017453242,-0.007650655,-0.06793563,-0.008166877,0.055408172,0.035667818,0.018378478,0.027859949,-0.025465064,0.022290692,-0.007056007,-0.03179426,0.022648748,0.030921517,0.023490686,-0.039901372,-0.05900549,-0.0977618,-0.041318357,0.098855495,0.010589146,-0.0881415,0.0013632965,-0.054603256,-0.047250886,-0.04033571,0.0069687944,0.05462693,-0.03198077,-0.034533396,-0.018924005,-0.013385598,0.07012223,0.04762606,-0.04565856,0.007486575,-0.091579534,0.0321474,-0.034122285,-0.051311363,-0.031446107 +3.5.2.20,"Requires Mn2+. This enzyme, found in several bacterial species, is involved in the degradation of indole-3-acetic acid.",384,1.0,-0.029322678,-0.09694616,-0.042180628,0.013668219,0.0679629,0.015719468,-0.034002587,0.001925305,0.0129846465,0.026515247,0.052779492,-0.04048703,-0.00011491795,0.0670296,-0.01617714,0.056362163,-0.07548594,-0.011263836,0.0064092674,-0.026287686,0.06416717,0.03512375,-0.018263368,-0.104177974,0.06863145,0.05301625,0.07351406,-0.10352112,-0.035657343,-0.04464644,-0.0035901123,-0.000509736,0.111696854,-0.07077426,0.06540856,0.09189173,-0.066981144,-0.060734212,0.06952903,-0.019473856,-0.036680516,0.022609528,0.031682957,-0.052849192,0.017006623,-0.0059564905,0.047301315,-0.07755407,0.07074763,0.0008118368,-0.050251216,0.010022357,-0.02280577,-0.001991722,0.034429442,-0.04217075,-0.056280278,0.014011076,-0.096324116,0.014734109,0.029498564,-0.0082745105,-0.0056790356,-0.016614068,0.01537438,-0.043485638,0.028211575,-0.057724237,0.03765825,0.06977627,-0.028224746,-0.05783514,-0.06587991,0.042954143,-0.0026162334,0.0023587488,0.053541306,-0.07149657,0.031171156,-0.058032364,-0.022909215,0.028877148,0.06947807,0.06693878,0.04429292,0.05120098,0.036205232,-0.026601324,-0.01057761,0.02618093,-0.0137263285,0.03231928,-0.0070865713,-0.020386532,0.032621246,0.024124814,0.006393801,0.025944682,-0.015202858,-0.0064063524,-0.005302493,0.08206673,-0.07251411,-0.08545026,-0.032817487,-0.038263537,0.019846544,0.07275996,0.010085131,0.058852155,0.07709706,0.014584213,0.003707478,0.00402612,-0.0008538672,0.087143354,0.06687911,-0.09285352,-0.07276413,0.037017215,0.02423733,-0.015339403,-0.022936247,0.03790346,-0.07889565,0.05752345,-0.013589566,-2.0239603e-33,0.039840568,0.038464975,-0.034535635,-0.04658243,-0.0018121001,-5.1667324e-05,-0.08041167,-0.047454294,0.03861096,-0.11566562,-0.042721402,-0.115813136,0.02042356,0.032666374,-0.015889566,0.004818312,-0.05714422,-0.046132263,0.09569153,0.005085977,-0.024186615,-0.012391682,-0.04551072,0.016140882,-0.06408547,0.024362486,0.14498757,-0.01966843,0.044696175,-0.030537503,0.0540537,-0.092899516,-0.11326716,0.00816416,0.03118453,0.041454457,-0.043919597,0.008187052,-0.036448456,0.03844725,0.029692678,0.115038626,-0.037131585,0.039942328,0.06403814,-0.08636318,-0.034962755,0.1177943,-0.003755387,0.03883216,-0.018577809,0.008309004,0.10722457,0.015029923,-0.0029538064,0.031965595,0.048353486,-0.004156948,0.021710496,-0.0032464275,-0.04523913,-0.014359351,0.02739085,0.12697944,0.027639141,0.011464795,-0.0691045,-0.05695546,0.008531554,0.0439155,-0.036707535,-0.10233376,0.053213283,0.03605754,-0.06680575,-0.06505613,-0.057392824,0.005491298,0.051701855,-0.0034000827,-0.036852937,-0.034134485,0.04839121,0.002755301,-0.037484832,-0.0358975,-0.05006992,-0.06475005,0.011838672,0.052077517,0.08493125,-0.0012229809,-0.117662914,0.09663095,-0.0250571,-4.258101e-34,0.052758534,-0.027164103,0.01833982,-0.08767334,-0.13153724,0.055126414,-0.015039068,-0.067761846,0.025382474,-0.0029696908,0.046021778,0.0020267498,0.06642899,-0.016567506,0.01013936,-0.04121866,0.008132294,0.08449505,0.012361942,0.042320937,0.028419666,0.12406007,0.0181039,0.020493483,0.018175043,0.060267534,-0.08867553,0.056110643,-0.04268254,0.0155863855,0.03290851,-0.04685616,-0.061700437,-0.07066406,0.021044126,0.02066802,0.0049144523,-0.047416653,-0.014989511,0.034564573,0.01034634,0.030276274,0.018177276,0.052553818,0.0291705,0.009359913,-0.022640256,0.04392581,-0.031287674,-0.06694403,-0.004321002,-0.061263807,-0.054609634,-0.07798587,0.010965829,0.02863885,0.008858336,0.042505987,0.0020743501,-0.041722458,-0.064087294,-0.051712207,0.07151806,-0.026985958,-0.027461693,0.051630493,0.06112561,0.093683794,0.04348333,-0.049664002,0.0068076225,0.07256259,0.078861736,0.04135342,-0.035009954,-0.06031501,-0.10323828,0.025332663,0.039516613,-0.06558101,-0.0068985526,0.042061046,-0.035175614,-0.06787461,0.010370627,-0.070945196,0.022138638,0.09379898,-0.051405385,0.021254238,-0.005119846,-0.073466465,-0.097670324,0.04401903,0.014053543,-2.734592e-08,0.007933475,-0.051641002,0.022035133,-0.0765733,-0.029166555,0.033069592,0.012691072,0.031351548,0.0939357,-0.0805867,0.011278256,0.071174584,-0.0379767,0.045364756,0.029837789,-0.013782394,-0.014697671,0.0304745,-0.06127924,-0.077461995,-0.08151019,-0.02357293,-0.06629162,0.09219908,0.02891389,0.024350764,0.04417594,0.03186308,-0.013699679,-0.066229634,-0.008702182,0.062844284,0.0027775555,-0.025061931,-0.07874708,0.05105126,0.04078027,-0.0043610157,0.013820245,0.04902443,-0.08580403,0.041793697,-0.08181637,0.011982254,0.03245751,-0.02751519,-0.03147867,0.040181316,-0.041005187,-0.0657518,0.022255858,-0.08466144,0.0232348,-0.049086433,-0.09093579,0.024526196,0.0033826586,-0.041149747,-0.006889414,-0.01792778,0.035189632,0.013691691,0.114816986,-0.029413788 +3.6.1.67,"The enzyme participates in a folate biosynthesis pathway, which is found in bacteria, fungi, and plants. Requires Mg2+.",384,1.0,-0.028893704,-0.04457829,-0.082066536,0.020995662,0.11783249,-0.014726009,-0.080759875,0.027189836,-0.002105306,0.01042338,0.048113655,-0.04279072,0.008357269,-0.02811871,-0.020823102,0.019073159,-0.040944394,0.05481635,-0.027991457,-0.0020361342,0.10624477,0.056034636,-0.019497158,0.010666153,-0.015272534,-0.026854658,0.077074856,-0.03824898,-0.0058105397,-0.012631806,-0.03968332,0.01817082,0.11410998,-0.044388723,0.0010778506,0.12151804,-0.021580676,-0.014411286,0.035007812,-0.04982619,-0.02495983,-0.051276777,0.071364,-0.045236617,-0.006903351,-0.04944876,0.074946225,-0.023826476,0.034411337,0.07021602,-0.07846441,-0.0022998594,-0.05327586,0.009407026,0.03329594,-0.0016387161,-0.03529439,0.002875562,-0.060706094,0.038917262,0.02315955,-0.03789181,-0.06273451,0.006594491,0.042286623,-0.010407187,0.016252998,-0.09662913,0.0044556237,-0.08344209,-0.0026857178,-0.07769564,0.009726792,-0.03430884,-0.034479875,0.05458403,-0.019089768,-0.03348808,0.053728558,0.022274982,0.056112047,0.035262194,0.055052303,0.07320043,0.07167046,-0.032838352,0.04467734,0.057965484,-0.00822521,0.10581416,0.058347836,0.015697896,-0.024174057,0.03840553,-0.095919326,0.018478677,-0.00045199363,-0.0097103575,0.019873792,-0.03510992,-0.03724901,0.05494117,0.002578134,0.011650345,-0.06248388,0.0067099165,-0.030107316,0.0496604,-0.0071034143,0.02338464,0.057187993,0.058157764,0.018016294,0.04059768,0.037980348,0.06351072,0.01201414,-0.1129249,-0.060192302,0.032925323,0.001962992,0.023971127,0.0053579193,0.06835701,-0.04994306,-0.008161208,-0.08620469,-2.0348918e-33,-5.5054472e-05,0.071918674,0.000746161,0.017386952,-0.0028670284,0.008577675,-0.030152231,0.015993547,0.009243963,-0.055181313,-0.07985897,-0.09497058,0.00074462465,0.04654292,-0.027085874,-0.05872246,0.018204384,-0.06416036,0.10485752,0.06943043,-0.0018377305,0.043519728,-0.00996225,-0.027339356,0.029992491,0.12120828,0.040516242,-0.018891597,0.04737607,0.0032520762,0.05130668,-0.14160852,-0.07963855,0.023955857,0.1070767,-0.012292585,-0.032576032,-0.03649121,-0.05695932,0.05118464,-0.056976225,0.020637944,-0.039734438,0.0026431833,0.03987011,-0.07398293,-0.015318724,0.073042504,0.064309366,0.07805812,0.0726588,0.013760213,0.04385638,0.04394503,-0.054919004,-0.0090929605,-0.06451166,-0.0026494954,0.012164957,0.02828294,0.012474398,-0.01355181,0.035847712,0.07920723,0.037573423,0.03285537,-0.11615968,-0.05545147,-0.0073708566,0.095156185,0.008181856,-0.041554257,0.08071856,0.015290846,-0.005494711,-0.0058112848,-0.050663766,0.0018476414,0.054037843,0.016657041,0.005453135,-0.04055986,-0.024158284,-0.038305573,-0.10721531,0.004300579,-0.030942239,-0.067409895,-0.015907567,-0.046992064,0.052095607,-0.036063954,-0.06662581,0.060203314,0.051336735,9.5741725e-35,0.12529236,-0.056754444,0.09290955,-0.07142879,-0.072462924,0.050719544,-0.00377098,-0.107687384,0.05657257,0.047779508,0.028105417,0.005322321,0.011722952,-0.06559783,-0.0134914145,-0.021886582,0.0123492,0.069541015,-0.030068405,-0.03797147,-0.025547145,0.09688796,-0.0016037863,-0.018019862,0.041690752,0.046642743,-0.029533666,0.050774332,0.021216493,0.07968323,0.01014264,0.06659523,-0.041324176,-0.06832907,-0.042310122,0.078614816,-0.041607667,-0.013247168,0.0020503553,0.07426314,-0.0021139695,0.051841836,0.07789679,0.060576838,0.03981589,0.04836468,-0.01880007,0.068119965,0.030578466,-0.12021202,0.035570838,0.016608605,-0.06740448,-0.017723627,0.020581387,0.016934061,-0.04473881,0.010747651,-0.004300543,-0.061857305,-0.02522883,-0.024331968,0.019243108,-0.027035177,-0.02383616,0.046330694,0.007341014,0.040156465,0.064412735,0.10037587,0.0789028,0.039255735,0.0630552,0.06620482,-0.046104215,0.07220656,-0.06543692,-0.044279337,0.015485899,-0.02439128,0.039112065,0.0056823357,0.023836093,-0.01346898,-0.062795915,-0.17818718,0.009322152,0.043565094,-0.0024585775,-0.03166851,-0.07795408,-0.019543253,-0.066779114,0.015012169,0.06951418,-2.547036e-08,-0.017196935,-0.10249243,-0.012087506,-0.07464608,0.01920574,0.04819514,-0.021666143,-0.002158015,0.064995445,-0.0044525755,-0.08034523,0.025111368,-0.071782425,0.00038341776,0.0048347632,0.0077477656,0.016852265,0.024957197,-0.043463938,-0.028963,-0.06966603,-0.040796157,-0.14580229,0.03287638,0.009234004,-0.09200912,-0.04170187,0.028375862,-0.026054988,0.016207715,0.027809579,0.01057855,0.010668725,-0.045399997,-0.09478592,0.081074856,-0.034852505,-0.047975823,-0.025689602,-0.05021659,0.012321457,-0.037592772,0.0091886325,-0.022694139,-0.045192216,0.009616328,-0.014558693,0.046521205,-0.046495892,0.023682531,0.049073823,-0.019696062,-0.0415381,-0.011803054,-0.064441666,0.0019336601,0.033050034,-0.06255219,-0.016585005,-0.07726746,-0.034229558,0.05362127,0.13614,-0.08409235 +4.2.3.148,"Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This bifunctional enzyme also produces (R)-nephthenol. See EC 4.2.3.149, nephthenol synthase.",384,1.0,-0.047619823,-0.05771314,-0.071091644,0.028371364,0.009751957,0.007619652,-0.03894271,0.022987738,0.014709608,-0.02374128,-0.011458569,-0.06501511,0.03321707,0.066291444,-0.0526485,-0.040568076,0.00043283578,0.023108354,0.02595305,-0.032629628,0.10293976,0.065206215,-0.026052518,-0.06265243,0.07824054,0.006123007,0.020413501,-0.07027266,0.0001662525,-0.062341392,0.015423636,-0.028271329,0.04752392,-0.11807508,0.12216717,0.10327721,-0.06531121,-0.008871361,0.05542009,-0.012796902,0.0046670637,-0.022276752,0.05250676,0.027911674,-0.04913636,-0.0062375674,0.057106342,0.046801876,0.043096025,-0.011579734,-0.115041874,-0.00623367,-0.059533726,0.03505192,0.070593424,0.016803782,-0.075243406,-0.028898478,-0.038695652,-0.041596908,0.05858111,-0.0026295437,-0.0023564547,-0.079137124,0.0050661736,0.036337882,0.022219194,-0.09129196,0.089280695,0.019848092,-0.046540048,-0.013027897,0.001242139,-0.008636071,-0.07241347,0.04000585,0.04903763,-0.07787976,0.024024308,0.029672131,0.0024577624,0.012319778,0.012463974,0.059325486,0.04922183,0.010382858,0.027865056,0.0658931,0.02000803,0.08126201,0.03906166,0.019941898,0.0005689849,-0.070310146,0.0045285607,0.031995736,-0.10738339,0.02954443,0.03029237,-0.024418794,-0.031524315,0.06532808,0.03408236,-0.0142954495,-0.072070174,0.0064588753,-0.036721304,0.027791278,0.04326363,0.022057425,0.04093889,0.005743936,-0.0034488998,0.006750393,0.008977145,0.06031069,0.039369714,-0.11999737,-0.092598096,0.0015900221,0.017005691,0.013051956,0.00074103096,0.029090028,-0.028203651,0.074885435,-0.11052652,2.8640595e-33,0.013170949,0.047292773,0.082893156,-0.004194884,0.006490065,0.05709312,-0.07096902,-0.017690392,-0.013481072,-0.066422366,-0.08392327,-0.107541494,-0.002787886,-0.0054629985,-0.03726794,-0.027208894,0.022785699,0.0015642724,0.06597283,0.022688909,0.0028830338,0.0676648,-0.05009234,-0.024024015,0.009642527,0.07227436,0.016621795,-0.04740697,0.09404277,-0.012834106,0.043548457,-0.079578236,-0.038399883,0.036162324,0.0822674,-0.074083984,-0.08333237,-0.02913882,0.002344549,0.025220009,-0.045393553,0.06605167,-0.02038757,0.020790586,0.073307574,-0.09063223,-0.036430318,0.072610304,0.06201108,0.08008939,0.04729801,0.036072027,0.038951002,-0.012998583,-0.060130823,-0.007252612,-0.04013364,0.074117646,0.12083084,0.045123525,-0.0057413355,0.071671225,0.03237941,-0.025445664,0.1269484,0.046927303,-0.06844079,-0.06628177,-0.029984549,0.03762975,-0.017526098,-0.060502302,0.043688875,0.03689459,-0.0015619782,-0.026986718,-0.04361896,-0.028659623,0.08266292,0.003561658,-0.041522697,-0.003907729,-0.0031114235,-0.059302554,-0.053929545,-0.0038480526,-0.036974814,-0.048143044,0.0066739847,0.059823137,-0.0044206474,-0.074776515,-0.10523028,0.030619022,-0.024651665,-2.9543301e-33,0.074295685,-0.056560997,0.014439532,-0.018085105,-0.104089215,0.049135473,-0.012980207,-0.08245545,0.030248564,0.045972552,0.11075675,0.014614652,0.029152177,-0.035220604,-0.004027346,-0.054141656,0.030385714,0.097593755,-0.005394495,0.027823843,0.05352842,0.12307318,0.0043871175,0.02448891,0.07407732,0.040685374,0.035818823,0.0666311,-0.020347293,0.047277395,0.0009962813,0.050475128,-0.05031683,-0.102339245,-0.090394415,0.01986792,-0.03698656,-0.011985243,0.043646492,0.016992636,0.040869925,0.086006366,0.07595845,0.08688129,0.013785088,0.000996711,-0.04140167,0.050014656,0.06063262,-0.09416583,-0.019869365,-0.03213445,-0.06396597,-0.058045972,0.017911594,0.0133019835,0.009975474,0.04683783,-0.014652734,-0.07121657,-0.03542442,-0.050222784,0.042643774,-0.069419704,0.045032386,0.06783513,0.0058194874,0.08143107,0.026046684,0.023563288,-0.02484344,0.028253244,0.06905009,0.0014382541,-0.004344759,0.01964671,-0.0604687,0.025180303,0.080841295,-0.090642914,0.02244625,0.018585585,-0.010744663,-0.03861494,0.027360227,-0.11003468,0.035657868,0.015205584,0.019016452,0.052442845,-0.09986913,-0.017941244,-0.07540348,0.063638344,0.05937875,-3.297207e-08,0.039677225,-0.018322045,0.0601628,-0.04523825,0.07834413,-0.000289892,-0.05591609,-0.07461071,0.056618143,0.03398704,-0.016002914,-0.07361843,0.006471053,-0.06933813,0.0032413406,-0.0012139395,-0.026878936,0.02661233,-0.04298111,-0.06356463,-0.027457278,-0.046004955,-0.09775688,0.055674836,0.055448387,-0.07921032,0.038599342,-0.014470038,-0.024863698,-0.005063914,-0.0022556614,-0.012766823,-0.026826024,-0.017530436,-0.060388934,-0.02897775,-0.08792921,0.014596972,-0.049066655,-0.054137703,-0.042749863,0.02569458,0.025790691,0.02977662,-0.06387552,0.02786779,-0.054390978,-0.027476478,-0.06381952,0.05146009,0.0736994,-0.021816215,0.003890195,0.011923106,-0.057526935,0.0522534,0.047418818,-0.054075807,-0.085017905,-0.04269299,0.01571029,0.0130485315,0.09091529,-0.029542854 +4.2.3.149,"Requires Mg2+. Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase).",384,1.0,-0.076284096,-0.05249329,-0.08930197,-0.014228242,-0.019953825,0.004525865,-0.06924802,0.050321925,0.066555135,-0.03011743,0.020470157,-0.12755056,0.06390571,0.043824837,-0.07024321,-0.037989248,-0.061037242,0.037652984,0.062105764,-0.05874673,0.029314252,0.0973275,0.022067849,-0.044366688,0.02449849,-0.026364079,0.07312487,-0.033620324,-0.04786754,-0.061124496,0.028305784,-0.015366349,0.04158631,-0.09327883,0.11869852,0.060264125,-0.052501217,-0.041650947,0.12055963,-0.0040127696,0.00075664476,-0.016635291,0.04353901,0.042951677,-0.023940522,-0.013837454,0.07188288,0.06356133,-0.0036685586,-0.028919471,0.021610342,-0.025587019,-0.07141754,0.08010517,0.061943118,-0.0281528,-0.07419088,0.03415238,-0.011456816,-0.010241385,0.08654165,0.021487024,-0.016369458,-0.06113513,-0.044178348,0.01436554,0.03253071,-0.07761838,0.06891535,-0.058526065,-0.06930109,-0.03937981,0.037109144,0.06654867,-0.040840063,0.07017397,0.030292833,-0.04613787,-0.0070438874,-0.032180406,0.02902938,0.013381462,0.024474077,0.04000598,0.030915722,-0.03816552,0.057159994,0.068487905,0.07162392,0.08705987,0.13639385,0.049207788,-0.05130121,-0.00338652,-0.02991626,-0.012225409,-0.026993873,0.091418184,0.04008993,-0.030305661,-0.05641479,0.035101775,0.018191267,0.0025861536,-0.0075453836,0.014136279,0.033191476,0.012998747,0.033764616,-0.047789827,0.061164733,0.036873065,-0.010098974,-0.043646097,-0.026341872,0.04159189,-0.016958814,-0.063518986,-0.015069924,-0.012936432,-0.03485073,0.04202701,0.028920442,0.021601317,-0.0048283553,0.02448341,-0.07413802,4.0159512e-33,-0.0031184466,0.041623104,0.06562395,-0.02204495,0.037380878,0.018647838,-0.05929468,0.040849254,-0.034475397,-0.031244596,-0.09180631,-0.094135806,-0.010367204,0.0603273,0.022712795,-0.023377111,0.010495228,0.017058682,0.039594628,-0.026125481,0.0042654057,0.04518913,-0.031435933,-0.031893734,0.06480051,0.07939341,-0.005555257,-0.015123929,0.0971307,0.008532137,-0.056176215,-0.12275103,-0.015580871,0.035630547,0.06272266,-0.003123055,-0.050402552,-0.020746246,0.015818479,0.024309441,-0.063807644,-0.00594592,-0.035433892,-0.017843667,0.0031243246,-0.061620496,-0.054456867,0.031232083,0.011738253,0.058091413,0.04944779,-0.03639844,0.05853096,0.005336899,-0.072798654,-0.010855901,-0.01292829,0.03368105,0.0667817,0.018153463,0.035609968,0.05917731,0.0036301939,-0.039992336,0.096703425,0.031589203,-0.07997148,0.018308327,-0.023634983,0.020891681,-0.036097143,-0.0717633,0.035513844,-0.026625212,0.016687682,0.027567988,-0.0926406,0.011288722,0.06115483,0.015935352,-0.065107964,-0.049053155,-0.01628298,-0.078959994,-0.04464106,0.084371515,-0.0703263,0.020395264,-0.013722029,0.09506049,-0.011075368,-0.022266397,-0.073539875,0.04008022,-0.0044980193,-4.8454406e-33,0.06536477,0.008592061,-0.0120564215,-0.071217455,-0.051943783,0.004903128,-0.055852283,-0.07698479,-0.0155637115,-0.04343093,0.08886364,-0.039148364,-0.022572666,-0.07322038,-0.019274365,-0.011818446,-0.033289056,0.15179919,-0.09126325,0.030506395,0.05711098,0.055672232,-0.05922806,-0.017943611,0.045692522,0.012076282,0.06863963,0.10240978,0.04757501,0.10825517,0.0013445873,0.026208717,0.002546452,-0.0139715485,-0.05477789,0.06109659,-0.034986217,-0.034608234,0.08790515,0.0780179,0.026847929,0.059143566,-0.009634466,0.11048408,0.08192958,0.0920617,0.020009596,0.012753709,0.057908442,-0.08267447,0.05198245,0.008836059,-0.0055538956,-0.038734734,0.0030939414,0.027664721,0.025324624,-0.014745332,-0.008502575,-0.088198766,-0.026570123,-0.08643961,0.032649443,-0.029865041,0.06803287,0.048282307,-0.061779678,0.06142929,0.024403222,-0.029960787,0.023234785,-0.056677956,-0.030668044,-0.01603106,-0.08486522,0.005767121,-0.046340704,-0.0032375085,0.06265823,-0.032360137,-0.002078334,-0.059559837,0.076863684,-0.04729268,-0.0015726354,-0.061052866,0.016524836,-0.01270101,0.008653051,0.09583499,-0.09223918,0.038400576,-0.038109396,0.06645619,0.07419083,-5.7254965e-08,0.059677977,-0.071972065,0.011744895,0.0030326666,0.080815054,-0.025778811,-0.06374301,-0.00010188535,0.0684325,-0.008533887,-0.058008872,-0.046848353,-0.052046392,0.00417661,-0.0006072377,0.010145101,-0.07974047,-0.02094469,-0.009273017,-0.022750197,-0.04587021,-0.06659618,-0.05377897,0.06181057,0.0053984444,-0.07866016,0.018692339,0.05727767,-0.008955376,-0.00442125,0.02256059,-0.010914242,-0.06297783,-0.017337956,-0.020669563,0.006497614,-0.09590209,-0.06086073,-0.02423481,0.04745882,-0.0046721213,-0.038873103,-0.05809089,0.027315246,-0.033069216,0.017060537,-0.0021797684,0.033919618,-0.09492757,-0.00707258,0.06743317,0.0059610587,-0.016858924,0.00830697,-0.05196875,0.090241864,-0.026857607,0.0068144766,-0.09973449,-0.024389429,-0.05041662,0.0242014,0.1364464,-0.0954776 +4.2.3.150,"Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol. See EC 4.2.3.149, nephthenol synthase and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase.",384,1.0,-0.017562047,-0.05546548,-0.079053424,0.03863046,0.014977997,-0.0045160465,-0.053820293,0.026957287,0.031437162,-0.034900572,0.003735475,-0.04895653,0.062025283,0.059796434,-0.06901874,-0.04706338,-0.037315737,0.038472664,0.029441116,-0.03582008,0.06643282,0.060494628,0.013343717,-0.08592844,0.023299096,0.04238104,0.06487478,-0.09734555,-0.018576978,-0.067909695,0.014808163,-0.014938977,0.033643167,-0.14499243,0.1389112,0.10548093,-0.033770785,-0.0023604168,0.06691037,0.0055938265,-0.0008839549,-0.013518417,0.05866784,0.013505125,-0.03590692,-0.03274695,0.051115483,0.031304426,0.054429203,-0.014063959,-0.067872256,-0.019568166,-0.06763099,0.055050306,0.09176809,-0.011871345,-0.09023773,-0.031280342,-0.012831193,-0.009795386,0.09453137,-0.00663074,-0.009501887,-0.054190613,-0.03160808,0.058919698,0.06187879,-0.07856862,0.08621904,-0.029451353,-0.02954371,0.01711865,0.014232351,-0.0008374293,-0.078821816,0.069281615,0.06693525,-0.048576914,0.028609794,0.036987837,0.018408662,-0.006020595,0.04465347,0.050834753,0.06409769,-0.00049966347,0.02441228,0.031314835,0.05324784,0.09456698,0.06044154,0.052014105,-0.024290202,-0.053805716,-0.023321558,0.005601765,-0.10389852,0.05043577,0.031576373,0.0052164537,-0.039421506,0.046389256,-0.0008512575,-0.010418775,-0.064458944,0.008872628,-0.021744186,0.036292225,0.05052744,0.014515009,0.06717859,0.025786808,0.032658014,0.00019545354,-0.018695353,0.05101772,0.02525461,-0.11168159,-0.05848834,0.012328115,0.005077465,0.028843196,0.013924986,0.036937896,-0.0104063265,0.059612576,-0.11747172,3.2516036e-33,0.008187643,0.070155196,0.10952193,-0.01040371,0.00572263,0.049466453,-0.08376904,-0.0014944831,-0.028218564,-0.0668693,-0.07561434,-0.10262564,0.0013858541,-0.00016294976,0.0019804253,-0.04777319,0.022248097,0.03389279,0.0686799,-0.022005213,-0.025989804,0.07845089,-0.046456933,-0.016097872,0.009226931,0.10906078,0.009611396,-0.07825832,0.109847724,-0.0018309939,0.004770157,-0.0742257,-0.049250845,0.038026843,0.042933967,-0.0476139,-0.059754644,-0.06489486,0.003219818,0.0009898298,-0.093249775,0.036229443,-0.012216548,-0.0017494075,0.06304556,-0.07879429,-0.061138414,0.042147525,0.037013233,0.06670349,0.017791277,0.032814153,0.051714525,0.0043400433,-0.10947658,-0.007924004,-0.03506538,0.040577617,0.12006343,0.040908303,0.010729015,0.07473242,0.00078369025,-0.049058467,0.11051481,0.036736485,-0.038613547,-0.047653843,-0.026531955,0.051181406,-0.000534586,-0.036113147,0.03441856,0.02412669,0.0037257636,-0.013212835,-0.04699697,0.0020703294,0.07530893,0.0058930954,-0.014252404,-0.03645913,0.014673258,-0.062847875,-0.04711116,0.0040960186,-0.04409547,-0.02981888,0.009932299,0.072747506,-0.0060220603,-0.022411464,-0.10888698,0.0512656,-0.044202257,-2.78474e-33,0.07581881,-0.03848832,0.006741613,-0.03687719,-0.11382562,0.035384934,-0.023055121,-0.049000837,0.009438024,0.032801352,0.12244024,-0.0076458384,0.029532043,-0.08375931,-0.015954923,-0.04345786,0.023540689,0.102992214,0.001469149,0.018944215,0.061922442,0.07803468,0.010268278,0.036403965,0.091533534,0.021526365,0.063121095,0.038311876,0.008232441,0.09566145,0.029140085,0.02193536,-0.036802858,-0.04798127,-0.08020326,0.026699187,-0.030113807,-0.039246984,0.06797831,0.039344758,0.022458265,0.07122196,0.051758282,0.08703093,0.02717133,0.026405782,-0.03831546,0.088978484,0.038888767,-0.09713834,-0.0027883982,-0.026835237,-0.06470626,-0.05490848,0.027067924,-0.0006094057,0.025228694,-0.011912753,-0.034769602,-0.054654285,-0.02226407,-0.08265613,0.044475347,-0.060831938,0.066005655,0.08848443,0.0051299264,0.0648484,-0.01749999,0.030972397,-0.021979032,0.012779475,0.04354646,0.021732667,-0.014836562,0.029837029,-0.024386805,-0.01823635,0.062243614,-0.08678082,0.021113861,-0.01909145,0.01711092,-0.062172607,0.028568063,-0.11147481,0.056253362,0.055411786,0.037200265,0.07120266,-0.11000813,0.0272893,-0.05054819,0.049237113,0.028528599,-4.6606182e-08,0.030898437,-0.057781667,0.056616493,-0.042248398,0.0580079,-0.019872045,-0.040614493,-0.05929921,0.054635357,0.011183824,-0.014659211,-0.062612295,-0.030781927,-0.060818356,-0.008711502,0.019105636,-0.055137217,0.009591903,-0.03351111,-0.043466974,-0.031626787,-0.040924612,-0.101620056,0.03181472,0.0404891,-0.11179323,0.03877772,0.008480161,-0.0093185855,-0.038679518,-0.005367235,-0.017802918,-0.040001813,-0.021882262,-0.080134094,-0.010230621,-0.102295555,0.0040373225,-0.037418943,-0.010052151,-0.058346577,0.005492373,0.017946942,0.019296424,-0.06363688,0.011867549,-0.037463795,-0.009013558,-0.079994634,0.045919437,0.058662813,0.008337631,0.016852845,0.009305549,-0.05464737,0.054233845,0.016951507,-0.04483221,-0.06451671,-0.040631242,-0.015990496,-0.014080768,0.09896706,-0.007967151 +4.2.3.151,"Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (R)-cembrene A. See EC 4.2.3.150, cembrene A synthase and EC 4.2.3.149, nephthenol synthase.",384,0.99999994,-0.016524483,-0.051503778,-0.08212731,0.042095844,0.031645775,0.03467429,-0.05749385,0.017458942,0.020567048,-0.041894697,-0.0032109118,-0.09403032,0.05044973,0.06942012,-0.07475779,-0.06483332,-0.014597219,0.03894019,0.03264853,-0.0601024,0.06262231,0.04741789,-0.0037481852,-0.06821285,0.04556946,0.018167889,0.03673387,-0.09025335,-0.008862212,-0.081362136,0.028974362,-0.016069576,0.05748549,-0.11596572,0.11209087,0.10079974,-0.020010816,-0.015720053,0.083618395,0.006621652,-0.020248275,-0.01410596,0.064838596,0.031557035,-0.04843912,-0.012620055,0.03355162,0.048669845,0.045144178,-0.038627673,-0.08709731,-0.016639568,-0.058129936,0.06750795,0.069553494,0.016923957,-0.077203095,-0.02996182,-0.02036626,-0.0063965335,0.10904703,-0.016483955,-0.0029553387,-0.05641182,-0.0046155937,0.07170959,0.029734505,-0.08162463,0.09361654,0.010604609,-0.034271326,0.0035781602,0.028931187,-0.0022263755,-0.063957915,0.06424897,0.066501,-0.0770514,0.03488349,0.021068843,-0.013235384,0.021667887,0.031157618,0.03640656,0.06593264,0.012094392,0.017447546,0.01633183,0.025983362,0.06480723,0.06376477,0.03863812,-0.035951838,-0.058038834,-0.0016450216,0.03291355,-0.10040244,0.021735659,0.05802841,-0.027867772,-0.021082288,0.07799316,0.0015422293,-0.00945922,-0.054474145,0.011462718,-0.011563536,0.04662834,0.03993667,0.02460732,0.041727204,0.014431527,-0.005214184,-0.0022324424,-0.016576776,0.043076243,0.046610944,-0.10374899,-0.09980588,0.0043369983,0.016621554,0.028622929,0.0071383542,0.020830523,-0.009082195,0.04584102,-0.1398038,1.568992e-33,0.027118694,0.058843926,0.0827834,0.0003436403,0.02086335,0.04818772,-0.091591515,0.009575592,-0.030305823,-0.06333808,-0.08327043,-0.08979678,0.002158221,-0.015766708,-0.024085525,-0.053242635,0.030261312,0.0069872243,0.061685853,-0.013928496,-0.018155448,0.07025295,-0.045819554,-0.016861351,0.0055366545,0.093732215,0.016832137,-0.04537832,0.10995573,-0.00035642923,-0.003570124,-0.07207618,-0.055873744,0.018672332,0.06440205,-0.06115318,-0.06687176,-0.042241577,0.0021220136,0.026872026,-0.05755728,0.07458949,-0.010357445,-0.0036047997,0.061399512,-0.088856295,-0.039611038,0.04453649,0.07455905,0.071795136,0.040287245,0.015607558,0.0584618,-0.001532362,-0.08161391,-0.013876679,-0.05428869,0.060500305,0.11865025,0.04222899,0.004686689,0.0581356,-0.00042001097,-0.03669445,0.13783337,0.048334844,-0.04559977,-0.03914375,-0.030086363,0.051531278,-0.017220309,-0.051561356,0.061721005,0.031791717,-0.0062114517,-0.012726608,-0.058807902,-0.02509933,0.060811747,-0.016069917,-0.046128884,-0.01924841,-0.005125041,-0.062065467,-0.03067405,0.0067081237,-0.042686537,-0.028172487,0.02617583,0.05196185,0.0003613921,-0.045228593,-0.09017436,0.017866809,-0.043509826,-1.4289333e-33,0.07131598,-0.02896853,-0.0016935462,-0.020852514,-0.10378749,0.035912763,-0.0074385465,-0.06665516,0.02824269,0.042511348,0.11833772,-0.003244506,0.038748372,-0.07957357,-0.006565071,-0.016835801,0.020410102,0.08348285,0.008826863,0.033569593,0.067478,0.09807952,0.0059495815,0.01994161,0.09703888,0.05250241,0.04468738,0.061775282,-0.0018594614,0.06822303,0.023223562,0.018980253,-0.041020084,-0.06980484,-0.089510664,0.0066002198,-0.032852657,0.000801668,0.06433662,0.0134395035,0.040407047,0.10144987,0.057878625,0.11863403,0.038581472,0.0105676595,-0.021665847,0.067797914,0.052090865,-0.07563323,-0.024558287,-0.05476545,-0.07826757,-0.05731407,0.0115666855,0.008397238,0.0010749488,0.036679495,-0.03787676,-0.04753646,-0.036379937,-0.08714759,0.05102606,-0.070141196,0.07509895,0.06676018,-0.012256066,0.08567743,0.024029758,0.033499323,-0.0058398377,0.023619542,0.050653245,-0.0047412873,-0.0318706,0.019387834,-0.04965821,-0.011403987,0.04742968,-0.06718594,0.014202726,0.0121997,0.011784637,-0.07428352,0.031680282,-0.1079739,0.04157308,0.037089802,0.03436873,0.054511167,-0.0941692,0.0010135269,-0.043790545,0.041074414,0.046065174,-3.9728302e-08,0.046173718,-0.014886656,0.04413161,-0.038751815,0.08382498,-0.0021951492,-0.05503708,-0.06423355,0.051944178,0.02355078,-0.022243915,-0.07590913,-0.017921716,-0.08100452,0.008901865,0.0005295275,-0.056585588,0.01967272,-0.04296413,-0.03721267,-0.031539373,-0.039710898,-0.11261327,0.057345904,0.050287236,-0.087240756,0.043590605,-0.031196173,-0.021718191,-0.024720468,-0.013127429,-0.009299149,-0.017266588,-0.011210284,-0.06611573,-0.029406333,-0.101332866,0.02392228,-0.049179368,-0.032573815,-0.031201763,0.011285359,0.0091716405,0.035045505,-0.08411373,0.028610488,-0.051539596,-0.018177418,-0.050585303,0.0459868,0.062082894,-0.015349525,-0.0054354747,0.034849137,-0.066971384,0.0578381,0.0023395987,-0.0266561,-0.069441065,-0.05964982,-0.013929821,-0.011263508,0.09538471,-0.034823436 +4.4.1.28,"The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster and is specific for L-cysteine (cf. EC 4.4.1.1, cystathionine gamma-lyase). It cleaves a carbon-sulfur bond releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The same reaction can also be catalysed by some pyridoxal-phosphate proteins (cf. EC 4.4.1.1, cystathionine gamma-lyase).",384,1.0,-0.04914146,0.010014748,-0.057337757,-0.015239371,0.12416677,0.05451582,-0.099145174,0.03094105,0.027807709,0.004456738,-0.025306815,-0.052612916,-0.04775541,0.09351281,-0.1138544,0.07935664,-0.053682234,0.042096157,0.00061460584,0.014272146,0.047163405,0.050577644,-0.015243639,-0.006342736,0.05638542,0.021772172,0.056954283,-0.034872025,-0.051980715,-0.0030254351,-0.02949147,-0.08465294,0.037560996,-0.07698984,0.08936275,0.14558034,-0.02982363,-0.06711661,0.06728802,0.01018247,0.02535946,0.029491307,0.055864137,-0.05695237,-0.014137935,0.03128885,-0.009032336,0.032578763,0.07306629,-0.07284151,-0.07805285,-0.030558797,-0.032740828,0.036951967,0.015290148,0.02500737,-0.104144335,-0.040236842,-0.0173908,0.028873568,0.10472666,0.019954791,-0.024330955,-0.038834583,0.018298991,-0.024637893,0.017344723,-0.061185,0.07396377,-0.06326442,-0.045114208,0.003939044,-0.021104993,0.027221281,-0.014713656,0.04744233,0.013477752,-0.022900851,0.008313363,-0.039980084,0.00847289,-0.008651814,0.014223226,-0.008358044,0.030896291,-0.008328954,0.004301372,0.010557029,0.067693345,-0.00054308004,0.0016060511,0.033430524,-0.030773027,-0.069586396,-0.033042498,-0.06108047,0.039417513,0.06697298,0.029041585,0.021743584,0.03549473,0.06802432,-0.0700352,-0.10923416,-0.05525964,-0.030505953,0.02123735,0.10776508,-0.016841544,0.021110756,0.04961039,0.008636871,0.03786239,0.023110822,-0.010016898,0.07132222,0.058489155,-0.03299851,-0.13495103,0.05939377,-0.011994603,-0.038566474,0.072767004,0.0336655,-0.04428215,0.038355548,-0.14795204,2.2680956e-33,0.05852726,0.017618768,0.035838265,-0.023466025,0.017382279,-0.023309126,-0.08346075,0.068271704,0.018256133,-0.035794485,-0.08943511,-0.013536793,0.057337273,-0.06203128,-0.07291417,-0.029671764,-0.01781362,-0.0075523094,0.057449035,-0.018932799,-0.01612633,0.05365667,0.031623926,0.0034409487,0.018817674,0.023359174,0.05815433,0.007885448,0.011363041,0.0057550096,0.036184054,-0.080743186,-0.12538496,-0.03984254,0.0760359,-0.0032268807,-0.03574003,-0.072251886,-0.006809301,-0.005248218,-0.077868454,0.034590583,0.010600704,-0.07103394,-0.004044136,-0.020472065,-0.033059124,0.08459796,0.03499193,-0.03570909,0.051091526,-0.051108327,0.044597168,-0.01141956,-0.11759382,-0.05570321,0.01407554,-0.05094224,0.0511498,0.10332937,-0.017502168,0.05043406,-0.057600632,0.015625209,-0.02172723,-0.029770207,-0.03386899,-0.06141021,-0.011469279,0.0874112,-0.017271176,-0.059957117,0.057521556,0.03466005,-0.034763917,-0.072834425,-0.056336697,0.00940484,-0.0041588596,0.027631175,0.021641392,-0.027438242,-0.008990182,0.027321119,-0.014589156,-0.029419817,0.016139682,-0.02731927,0.019671071,0.07469434,0.007871883,-0.07014341,-0.016116368,0.042236943,-0.011511717,-3.4833876e-33,0.10845442,-0.07845413,-0.031365816,-0.084513724,-0.050916508,0.081753686,0.026403768,0.01803449,0.019492267,-0.06552142,0.11274377,0.005274566,0.047342535,0.019225981,0.03735734,-0.028706156,0.0502328,0.04058429,0.048605643,0.023820626,0.0172436,0.050201315,0.020276615,-0.010235577,0.1127947,-0.002215982,0.023853926,0.06916184,-0.028886762,0.06960151,-0.015383259,0.01692221,-0.061690148,-0.08534907,-0.06977109,0.03441542,-0.03619729,-0.064448655,0.088972785,0.029637462,0.05134567,0.062234882,-0.007988094,0.10770432,0.01813794,0.021184772,-0.060670502,0.031431954,-0.03875021,-0.02589652,0.048931103,-0.061107982,-0.00096258597,-0.053406645,-0.006188801,0.05102882,-0.017227562,0.028419321,-0.011911302,0.03731927,-0.049785145,-0.10533373,0.018848903,-0.02577844,0.040211044,0.056098644,-0.016047407,0.016553111,0.029509824,0.022344295,0.023039076,-0.037580594,0.0697843,0.07144547,-0.06853428,0.0062496946,-0.051398892,0.04084671,0.046393894,-0.049400404,-0.010855804,-0.024609016,0.053190917,-0.0650148,0.009317838,-0.09308026,0.09120206,0.12531568,-0.009604063,0.001030439,0.012066053,-0.004657623,0.0018492945,0.061576307,0.053696975,-4.5818428e-08,0.061391026,-0.079785705,0.018078223,-0.005623384,-0.08163563,0.010559746,0.06867441,0.033070695,0.032371204,-0.034288608,0.054020956,0.09228775,-0.032037254,-0.033469025,0.001903513,0.04238169,-0.08567277,0.06565359,-0.040212248,0.02699416,-0.019307373,-0.033258438,-0.14290294,0.01536099,0.011097869,-0.08208864,0.043639336,0.021770056,-0.040154822,-0.06128522,0.030893253,-0.009065218,0.017620945,-0.036110606,-0.08835638,0.00501492,-0.10926966,-0.04047871,-0.0149656,-0.039175373,-0.0013279673,0.040559288,-0.09374023,0.022447528,-0.029775957,0.023699393,-0.01662333,0.06085927,-0.041062366,0.008879348,0.045384876,-0.009756658,0.03005569,-0.07104466,-0.06755362,-0.00031697808,-0.0011113437,-0.041252572,-0.012668631,-0.04434247,0.03716732,-0.005447969,0.124585815,-0.016504584 +5.5.1.25,"The enzyme, characterized from the marine bacteria Vibrio sp. EJY3 and Postechiella marina M091, is involved in a degradation pathway for 3,6-anhydro-alpha-L-galactopyranose, a major component of the polysaccharides of red macroalgae.",384,0.99999994,-0.011702053,-0.0880534,-0.09154425,-0.03566142,0.012393591,0.07953671,-0.04252858,0.012997027,0.018908203,-0.017485768,-0.010423255,-0.03463839,-0.08306736,0.0012933858,-0.055084713,0.059045844,-0.006833744,0.042283684,-0.035735797,0.02292217,0.13197945,-0.003184226,-0.10561827,0.02298369,0.026748162,-0.046990454,0.0059719114,-0.037761718,-0.093411185,-0.06701405,-0.03682621,-0.0036814983,0.12964283,-0.01721049,0.061084833,0.101780474,-0.03688782,-0.15082105,0.043599423,0.014038217,-0.041017246,0.01786837,0.080853954,-0.024822775,-0.014299087,-0.004929154,0.008226625,0.048058506,0.097475536,-0.0826495,-0.06348767,-0.09073098,-0.061159432,-0.019722844,0.04962232,0.06264295,0.004068476,-0.110121235,-0.0064734947,0.0109599875,0.0736971,0.08316958,0.014396634,0.027194966,-0.069036715,-0.043552976,0.058451843,-0.03108185,-0.037945397,0.049119126,-0.14902198,-0.04986815,-0.06937713,0.015434438,-0.0051073246,0.08037422,0.028624594,-0.02565042,0.012046919,-0.052486137,0.040436164,0.012364367,0.016914062,0.02442523,-0.028766135,-0.06735654,0.05184782,-0.007937309,0.06373323,0.02126183,0.033833567,0.027567027,0.015590704,-0.065219305,-0.048356865,0.032284733,-0.00038147875,-0.05474149,0.09123906,-0.0029012924,-0.053808525,-0.0052440534,0.07934652,-0.059858665,-0.061648108,0.06335983,-0.0016206239,0.10469739,0.07805562,0.039622653,-0.043333236,0.002575838,-0.015600894,-0.031412493,-0.047504067,0.09722386,0.03214415,-0.039058033,-0.053112835,0.013568792,0.08251342,-0.04903549,0.109943934,-0.008842582,-0.025560286,0.029355617,-0.03579489,4.250344e-34,0.037624564,-0.050135072,0.046151746,-0.0071267607,0.07680609,-0.020552276,-0.06136982,-0.05813043,0.007764741,-0.016152598,-0.09883068,-0.048537116,-0.007076456,0.06198121,-0.0024396044,0.072973065,0.031428203,-0.030350342,-0.040190227,0.046476834,0.0049997726,0.05175462,0.02153081,-0.04525835,0.03319941,0.047136135,0.03413677,-0.026037037,0.037996966,-0.0064185425,0.033740368,-0.057865966,-0.14603433,0.045918632,0.10270018,0.0069441674,-0.067165986,-0.041280042,-0.010530123,0.011555637,0.033012796,0.0297895,-0.052989542,0.0047140336,0.044012368,-0.06389229,-0.018822853,0.04483916,0.05735325,0.03837691,0.031128349,-0.013293161,0.0044413633,0.04770873,-0.056137558,0.028958056,-0.014111505,0.06688481,0.014673262,-0.005970484,-0.035561293,0.049042415,0.015731465,0.027648536,0.056967877,0.05606882,-0.03065926,0.0148242125,0.0287652,-0.009291318,-0.05417796,-0.03953035,0.007220729,-0.03437458,-0.028541861,-0.067686334,-0.050895814,-0.04296646,0.013822343,-0.042032503,-0.03761701,0.011560105,0.063163005,-0.0125854835,-0.07813007,-0.008394949,-0.0032183104,0.03436705,0.022270838,0.030151382,0.054961234,-0.03636893,-0.021714935,0.010331477,0.03720718,-3.0056557e-33,0.04535416,-0.038340144,0.05102393,-0.027534084,-0.006071336,0.024924839,0.027685324,0.01549775,-0.057954784,-0.064286865,-0.0029060289,0.025265569,-0.02551999,-0.07003931,0.0422634,0.029630681,0.0589367,0.06413775,-0.08530844,-0.016091032,-0.011160768,0.03802382,0.081326045,0.01239145,-0.012971467,-0.041756157,0.011012257,0.07029393,-0.013727968,0.028832207,0.07120454,0.041808672,-0.010286381,-0.04816461,-0.04543157,0.019021515,-0.07054444,0.00853345,0.056016944,0.059321202,0.07366924,0.051038746,0.0071267644,-0.017412407,0.033889562,0.093301386,-0.1086265,0.046834704,0.03085694,-0.06462121,0.009264618,-0.04982689,0.046559073,0.020381214,0.025067056,0.053154092,0.05533283,0.030056069,0.02224411,0.013909842,-0.05075955,-0.013907343,0.06036907,-0.018587561,0.09441911,0.034332782,0.040369824,0.053296696,0.02609609,-0.016428918,0.11231268,0.03510114,-0.07835019,0.070762485,0.0035499474,-0.034007754,-0.12850113,-0.04435201,-0.013084245,0.025537364,0.07371334,0.010693316,0.019810518,-0.0597636,-0.014300402,-0.10235251,0.058348563,0.073705904,0.0024848122,-0.018228173,0.0033338012,-0.03759146,-0.09314919,0.0034372865,0.04290899,-3.425264e-08,0.09561461,-0.064654045,-0.021917563,-0.06546892,0.012787969,-0.031222729,-0.021176755,0.07303566,0.07295248,-0.037494235,0.007392573,0.048754673,0.0049450034,0.0074833287,0.006515865,-0.007583448,-0.03641281,-0.01271474,-0.03779045,0.064764604,-0.06025214,-0.011595387,-0.13645232,-0.018578682,0.014901271,-0.07563425,0.008946734,0.077497736,-0.012940621,-0.021563198,0.037335258,0.0647446,-0.012284125,0.0040253364,-0.10396224,0.0068964697,-0.017611006,-0.034286607,0.013534879,0.013747261,-0.004698686,-0.06534662,0.0023800414,-0.06259711,-0.06182644,0.0597071,-0.031974003,0.027700538,-0.03562357,0.014800425,0.01600666,-0.012681311,-0.0802642,-0.02516204,-0.093292,-0.0729172,0.047712438,0.0062923688,-0.029651344,-0.08511568,-0.024166074,-0.08836307,0.13136227,-0.023254715 +6.3.2.45,"The enzyme catalyses the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division. The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in vivo and in vitro. Requires Mg2+. ",384,1.0,-0.046883725,-0.06935451,-0.06307345,-0.015813893,0.00678977,0.010557338,-0.010925323,0.07305266,0.040466346,0.06435152,0.003316035,0.06931703,0.080343075,0.097120985,-0.0072532753,-0.0056634075,-0.032695156,0.017712686,0.0131985,-0.030019453,0.04494373,-0.019682426,-0.054859784,-0.042288188,0.026690373,0.05638781,0.04607475,0.01906125,0.048495676,-0.07152224,0.012297977,-0.06781867,0.021862421,-0.06925277,0.09084789,0.05434067,-0.048710916,0.03808041,0.09465963,0.011604846,0.01892205,0.049534593,0.01878796,-0.073262215,0.067383364,-0.0716441,-0.062119145,0.049753442,0.062526055,0.00985121,0.02250169,-0.015057635,0.004165096,0.061744105,0.029781058,0.058661178,-0.077425644,-0.022475721,0.04897888,-0.015214624,-0.021481097,0.031479605,0.06484308,-0.05605529,-0.08719781,-0.07746721,-0.029204967,-0.0226297,0.0822365,0.035364047,-0.041123394,0.019138865,-0.01667409,0.002619322,0.05979258,-0.041434385,0.009991397,-0.04108144,0.0404661,0.014907126,0.039054543,0.008757641,0.062017452,0.0953854,-0.0010233864,-0.022994125,0.068818755,0.015841313,0.051331434,0.019072255,0.06411779,0.0062864474,0.006271982,-0.033089343,-0.05857199,-0.07640085,-0.071371324,-0.011077687,0.027265327,-0.010369587,-0.017571034,-0.004337361,-0.06090651,-0.049408175,-0.036453187,-0.0032189912,-0.03659879,0.09525361,0.1252238,0.006149505,0.045683853,0.031142233,0.024446726,0.06521447,-0.02061575,0.114231765,0.018086089,-0.07193743,-0.00066855334,-0.044838488,0.064536236,0.041417856,0.035558753,0.020084115,-0.0010912074,0.06544449,0.021566233,3.0324597e-33,-0.011082203,0.030247616,-0.00084823463,0.057919342,-0.0418152,0.016509399,-0.029913643,0.01394397,0.011537176,-0.0745074,-0.12332464,-0.06116495,-0.052775037,0.09422651,-0.008588794,0.053013276,-0.0071421512,0.043658964,0.0500318,0.022791624,-0.021147948,0.04113265,0.016070064,0.004433807,0.12246231,0.046146594,0.037486453,-0.007208962,0.05402219,-0.012483176,-0.01738102,-0.07490536,-0.052993365,0.007675285,-0.017130211,0.027667454,-0.02981083,-0.030940128,0.054413863,0.0413364,0.010437927,0.018233825,-0.02349301,-0.043850213,0.03088691,-0.010711856,-0.014328254,0.08457438,-0.01000491,0.03337744,0.07153606,0.03597559,0.077632874,-0.046029102,-0.14280707,0.009818783,-0.060487777,-0.03639188,0.09988522,0.01956302,0.07230571,0.02144977,-0.00977411,0.056756914,0.06242207,-0.0119661465,0.025518999,0.014678813,-0.04055326,0.049637202,-0.06640928,-0.049008276,0.055836968,0.01513671,-0.019668717,-0.062491614,-0.021919552,0.051248487,0.05510761,-0.029863445,-0.030891832,0.018731214,-0.03234541,-0.03403901,0.0048943413,-0.02426715,-0.002127559,-0.07840429,-0.014306277,0.039696172,-0.013119818,-0.08275593,-0.057364427,0.09793824,-0.033105116,-3.5972493e-33,0.07520632,-0.12483856,0.029557489,-0.043949693,-0.11429793,0.048195455,0.005605707,0.028648913,0.057806574,-0.0194671,0.014332198,0.043545354,-0.023733174,-0.02447257,0.036160834,-0.060532477,-0.058445174,0.08452984,-0.082383126,-0.009084312,-0.033846542,-0.012928672,0.015820427,0.008662359,0.068722345,0.039533645,0.022721633,0.016018638,0.08470759,0.069875576,-0.00070528896,0.012691726,-0.051178556,-0.050105456,-0.05890923,0.084698975,-0.014038741,-0.078238465,0.014528247,0.028421085,-0.013549657,0.06255435,-0.005331124,0.027441263,-0.014704507,0.07544322,-0.007977449,0.010948047,0.021152664,-0.039252736,-0.03427555,-0.065446354,-0.010317327,0.016629674,-0.016946992,0.023453234,0.013439415,0.024903348,-0.012993647,0.016586,-0.038325872,-0.05566861,-0.0025338358,-0.037432816,-0.00483632,0.10209835,0.036665663,0.05513485,-0.008486995,-0.02763757,0.033161037,0.039766345,0.031182665,0.0464173,-0.006317036,0.08210881,-0.060299177,-0.09205145,0.008811365,-0.07161893,-0.0138975475,-0.043907028,-0.056643397,-0.037807867,0.012050705,-0.13604319,0.004060261,0.1399233,-0.01628689,0.06754809,-0.02323527,-0.107284546,-0.002567455,0.01008803,0.05841422,-5.303886e-08,0.002526525,-0.055160426,0.027782308,-0.07560509,-0.013702332,0.0015714003,-0.02295314,-0.025844084,-0.0057505034,-0.063231274,0.00081165635,-0.0010126102,-0.062652044,-0.013822847,-0.08309092,0.11870192,-0.101021476,0.017514916,-0.014005786,0.0041992054,-0.12712197,-0.03534307,-0.06847491,0.022877276,0.036360294,-0.087221295,0.047465548,0.056039434,-0.046134055,-0.03938258,0.004895007,0.036416937,-0.0424624,-0.03352617,-0.037468694,0.0009861405,-0.046142414,-0.018353423,0.044399012,-0.064063884,0.034928594,0.0014107114,-0.07241167,-0.04578483,-0.024057323,-0.01426761,-0.063253224,0.056158826,-0.11054751,0.017655743,0.017316274,-0.023174541,-0.028156346,-0.05289593,-0.11456843,0.03565715,-0.05054968,-0.113725536,0.063498706,-0.069899574,-0.040512163,0.047507014,0.1714136,-0.0123064695 +6.3.4.24,"The enzyme, which has been characterized from the archaea Methanocaldococcus fervens, participates in the biosynthesis of the cofactor methanofuran. Requires a divalent cation for activity, with Mn2+ giving the highest activity, followed by Mg2+, Co2+, Zn2+, and Fe2+.",384,1.0,-0.020931913,-0.069450945,-0.11974562,0.0391865,0.081362724,0.01091647,-0.056596722,0.005712304,-0.021459453,-0.02506003,-0.050551962,-0.08479131,-0.016480591,0.035706963,-0.048205767,-0.0031786682,-0.042139966,-0.027497023,0.05085783,0.0038796875,0.09143442,0.094156995,-0.010115702,-0.040869053,0.0027956318,0.03650405,0.018506926,-0.07001405,0.002456287,-0.024952108,-0.004045975,0.00028756878,0.10416544,-0.057801034,0.045159936,0.116580874,0.013325658,-0.027720159,0.059704777,-0.0028031277,0.0058683716,0.018157572,0.12116574,-0.04651068,-0.027816733,-0.04694798,0.09649396,-0.0439382,0.014176829,0.016906697,-0.052446064,-0.022727888,-0.064747095,0.049650766,0.07094562,0.061038412,-0.05740644,-0.058150977,-0.014043646,-0.05299349,0.011279422,-0.010909466,0.008135944,0.024030417,0.03726412,-0.057108212,0.033457723,-0.08814378,0.06881161,-0.039227996,-0.014966248,0.032269105,-0.04066805,-0.12400446,-0.05253131,0.040468812,0.03462284,-0.07847263,0.06473325,-0.03328619,0.015810957,0.035695747,0.06368967,0.032653425,0.062558904,0.018733485,0.039280858,-0.037636705,0.04110872,0.040501863,0.020954106,0.009022876,0.029518303,-0.025665548,-0.11897755,-0.023797782,0.058106672,0.06276589,0.009723007,0.033882495,-0.012069107,0.046544053,-0.025030721,-0.0486684,-0.05315484,-0.020623952,0.03430436,0.13223174,0.04251576,0.11948772,0.092349544,0.02516627,0.043770056,0.037808754,0.017877165,0.08053031,0.030919382,-0.13040848,-0.055126578,-0.0038121021,0.054535437,-0.031282645,0.026169812,-0.0009914367,-0.07071264,0.047769506,-0.102475755,3.1570865e-33,0.04964439,-0.0072748293,0.0017494971,-0.028339006,0.026071228,-0.03534372,-0.09493253,-0.014454794,0.04210216,-0.04766067,-0.09742719,-0.0075584133,0.08461443,0.008600333,-0.07955779,-0.08097236,-0.003880318,-0.047870062,0.0794239,0.041764375,-0.022857416,0.08295247,-0.04833369,0.02000256,0.025984718,0.028476333,0.021947203,0.00547808,-0.014179458,0.0022471892,0.027216574,-0.15338834,-0.07606473,0.03528341,0.11793529,-0.022790516,-0.055105377,-0.032448985,-0.040948376,-0.0334291,0.00378711,0.02513127,-0.057929147,-0.015959615,0.059749186,-0.02509332,-0.011431049,0.13429104,-0.03181483,0.07047817,0.027234951,0.009457577,0.039331295,0.010577418,-0.10081629,0.040069994,-0.014959737,-0.046135973,0.057454094,0.09154976,-0.068640865,0.013524171,0.03682477,0.093447305,0.012229458,-0.008714091,-0.006154935,-0.060052134,0.06890525,0.09283502,-0.03677048,-0.017673904,0.011551788,0.07978361,0.018228522,-0.024648998,-0.001597677,-0.027930988,0.0372584,0.009121562,0.043123618,0.011628981,0.03898076,-0.040105745,-0.070386715,0.03469488,-0.060435545,-0.07706756,-0.029944453,0.021139827,0.023147495,-0.05049707,-0.011189399,0.009915778,0.0005409996,-3.92688e-33,0.058037184,-0.09501742,0.06482276,-0.10658399,-0.13762891,0.074609436,-0.0060284105,-0.10348423,0.00030678016,-0.041209485,0.08945308,0.008770893,0.06883653,-0.048439026,0.03416256,-0.0393575,0.01818729,0.09454959,0.042494733,0.019844841,0.04425843,0.06792929,-0.052962866,-0.060045104,0.033297703,0.020122785,-0.030198762,0.022041138,0.026813539,0.034793213,-0.016958067,-0.014216219,-0.05404795,-0.09283526,-0.09432716,0.024007676,-0.030577766,-0.03230441,0.009206898,-0.01004173,0.034504015,0.053534623,0.013979229,0.08836523,0.019068532,-0.013787292,-0.095266744,0.016274584,0.020958116,-0.026541052,-0.024783242,-0.05422347,-0.053231772,-0.060867358,0.026167719,0.04604992,0.04839131,0.015412021,0.050777122,0.0064277668,-0.015522481,-0.04094235,0.056192104,0.007983535,0.0629172,0.038853034,0.005536534,0.03895327,0.014105967,0.02122802,0.05134598,0.06972306,0.045945324,0.056071978,-0.020946532,-0.046911124,-0.06760593,-0.026779845,-0.008704961,-0.011727978,0.014333946,0.011649355,0.0490026,-0.073139206,-0.02998692,-0.060969114,0.09042766,0.038571835,-0.0061830143,0.018944293,-0.050213207,-0.021934697,-0.06544841,-0.01897026,-0.009827471,-3.8765503e-08,-0.045879886,-0.040525522,0.026244614,-0.06935105,-0.029559989,0.07951481,0.0127056185,-0.07024896,0.033159472,-0.028030192,0.06992278,0.06172799,0.013748796,0.012932495,0.015450269,0.0073922332,-0.029693363,-0.00871967,-0.069947,0.0038387612,-0.03739822,-0.028412595,-0.06952204,0.05274476,0.017281339,-0.07818605,-0.0052201464,0.09040695,-0.032989275,-0.025430765,-0.036857188,0.026654586,0.013608162,-0.067235686,-0.105031885,-0.010026713,-0.022717496,-0.042706378,-0.04949016,0.0074790963,-0.02259259,-0.000605182,-0.0066601266,0.035568617,-0.040176563,-0.025075166,-0.046553645,0.04941515,-0.022559725,0.024162179,0.050192595,-0.041232124,0.016534097,-0.06527184,-0.055697,-0.02647979,0.020565243,-0.012954832,-0.06105084,0.030795481,0.036027882,0.015049719,0.095970124,-0.0549331 +1.14.99.50,"Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and gamma-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine.",384,1.0,0.008654353,-0.044318605,-0.075139165,0.030169856,0.11549344,0.03851275,-0.0112654595,0.060464203,0.018597499,-0.028362278,-0.014554679,0.004526425,-0.008141893,0.070272416,-0.032029543,0.014725732,-0.044410557,-0.03407116,-0.007244146,-0.034940798,0.025026532,0.019431744,0.032835204,-0.035109255,-0.036839,-0.0067874584,0.09260633,-0.009683003,-0.042307153,-0.04784719,-0.055921808,-0.071116194,0.06330766,-0.021310063,-0.016127469,0.10390618,-0.06734055,-0.031336162,0.046699487,-0.023985015,-0.05261493,-0.039846737,-0.021924557,0.04353471,-0.023577955,-0.044182584,0.046128638,-0.021034177,0.041423727,0.024617782,-0.008917246,0.016195359,-0.041566264,0.046169907,0.05108112,0.037956968,-0.065442204,-0.027861325,-0.03255987,0.014344641,0.054926615,-0.008460113,-0.037124265,-0.0061036446,0.021909235,-0.030395258,0.07086228,-0.04892317,-0.0050613754,-0.03396246,-0.021231327,-0.04913717,-0.021773964,0.023964781,-0.0068804654,0.02220769,0.05203979,0.014286227,0.033486202,-0.02461105,0.0098320935,-0.05615694,0.07575023,0.12790008,0.05370192,0.042300213,-0.045061305,0.026600111,-0.005092423,0.08135776,0.054426555,-0.00083621754,-0.06064219,-0.048049938,0.017133586,0.019964362,-0.0108830435,0.002287127,0.057853352,-0.031076357,-0.035043083,0.07536454,-0.0051614903,0.019044364,-0.025005313,-0.0034008306,-0.011017761,0.057255335,0.004030083,-0.03332157,0.086233586,0.019262185,0.015484421,-0.016050294,-0.026143784,0.07274002,0.08747267,-0.059292372,-0.10665576,0.032303277,0.024603166,0.0372212,0.019326845,0.06050089,-0.042967867,-0.026257737,-0.13641977,2.8254038e-34,0.06995442,0.08748491,0.0023195343,-0.039256178,-0.028380893,0.105393425,-0.043906115,0.0009318128,0.020546582,-0.040261712,-0.11081918,-0.094797425,0.053978343,-0.011384572,-0.019550638,0.003860692,0.010706403,-0.077480584,0.10239732,-0.022927724,0.023621308,0.005346277,0.0028971003,-0.047125872,0.0005024341,0.11778812,0.024710264,0.050432783,0.01095728,-0.00043265085,-0.004159228,-0.10607533,-0.06120302,0.07179875,0.10707589,0.0041153003,-0.045325384,-0.008510087,0.031943724,-0.011483898,0.029442871,0.09041627,0.020317279,-0.04094705,0.020578928,-0.08292226,-0.053580668,0.07719992,0.01516111,0.109558605,0.028402692,-0.027847122,0.07035074,-0.052752692,-0.0639549,0.03959217,-0.0121468445,-0.005723352,0.05757735,0.08212709,0.018097622,0.0509926,0.0068189423,0.10102891,0.08283176,0.029982733,-0.057102315,-0.010306054,-0.0536378,0.101047985,-0.03689256,-0.028970052,0.08974893,0.019408954,0.0071369647,-0.04171135,-0.13031884,-0.022851653,0.07586249,-0.015568072,-0.0050667566,-0.08793102,-0.020822575,0.030365948,-0.0645358,0.012195546,-0.025374994,-0.06796815,0.014579157,0.050014604,0.017313674,-0.041015446,-0.04678426,0.009503854,0.019648297,-2.6235838e-33,0.05601268,-0.09426905,0.043239158,-0.08595568,0.008754008,0.06831726,-0.017317096,-0.13169828,0.03810118,0.051773556,0.074936785,0.013691165,-0.05533958,-0.06978973,-0.03637681,0.019388514,-0.058304723,0.077468276,0.016182857,-0.007911699,-0.043105718,0.050856043,0.004038017,0.039136533,0.06917441,0.007651197,-0.02549323,0.026399508,0.021307327,0.07829398,-0.049368087,0.020772636,-0.047598142,-0.13309263,0.0082565285,0.025999524,-0.035426553,0.002582901,0.057928044,-0.002842083,0.024715431,0.056086283,0.011016553,0.09625944,0.02171438,0.11130084,-0.059287902,0.06407311,-0.02633042,-0.059351277,-0.009909264,-0.03784177,-0.037768252,-0.009755276,0.008164676,0.01551013,0.056075707,-0.01933976,-0.012668004,0.02459688,-0.024102736,-0.062693276,-0.021677637,-0.0045006042,0.025071627,-0.00024771402,-0.015877659,0.1004138,0.021149868,0.02369447,0.03991669,-0.053047884,0.04869781,0.05045515,-0.08875368,0.024920061,-0.041863807,-0.03289655,0.05093406,0.029928694,0.055264812,0.046515606,-0.011804342,-0.040907603,-0.018685758,-0.13801266,0.0051695453,0.09429288,-0.045616355,-0.013085485,-0.01908823,0.008083327,-0.056319185,0.031288616,0.025531033,-3.3583927e-08,-0.006390646,-0.07863562,0.010977767,-0.1073402,-0.016541509,-0.0089372685,-0.002938357,0.03010666,0.041068204,-0.028184202,-0.04226058,0.10192377,-0.0030319993,0.0063259676,-0.0023496917,0.0075576045,0.013577601,0.044230975,-0.0473885,-0.0015713046,-0.10819164,-0.04055812,-0.10006157,-0.035161935,0.017185425,-0.08704784,-0.045734446,0.016046913,0.0010979741,-0.04427288,0.01786103,0.02092468,-0.018607713,-0.04616685,-0.14017712,0.00040964925,-0.018628225,-0.08744531,-0.009158892,-0.03233829,-0.010815163,0.021582102,-0.047801055,0.0048565078,-0.009728151,-0.0013054811,0.009009717,-0.0005594642,-0.03364984,-0.018757507,0.023805441,-0.059110906,0.029213628,-0.09269038,-0.06486784,0.064819716,0.02363286,-0.061341356,0.05106262,-0.11841585,-0.01619907,0.0046927184,0.17018782,-0.064181596 +1.1.1.382,"The enzyme, characterized from the bacteria Thermacetogenium phaeum and Desulfococcus oleovorans and from the archaeon Archaeoglobus fulgidus, is specific for NADH [cf. EC 1.1.1.86, ketol-acid reductoisomerase (NADP+) and EC 1.1.1.383, ketol-acid reductoisomerase [NAD(P)+]].",384,1.0,-0.099512145,0.004228773,-0.08559377,-0.028741395,0.014277165,0.049965344,-0.12953585,0.041834287,0.029981457,-0.006797945,-0.027000137,-0.07536984,-0.08525463,0.027765093,-0.072960846,-0.037053507,-0.039507598,0.023814572,0.039923705,-0.042204976,0.1009563,0.07446661,0.00038374937,-0.01594378,0.06151378,0.04641986,0.017972475,0.009659787,-0.04083828,-0.09120489,-0.055574413,-0.05616511,0.07909025,-0.07309838,0.08418748,0.09237528,-0.08738339,-0.055705443,0.009091662,0.009461383,0.02905458,0.019029183,-0.008448953,-0.02573257,-0.049198665,-0.02247182,0.011847056,0.107669786,0.08625542,-0.008213754,-0.032963403,-0.032539677,-0.047474734,0.03344458,0.04540116,-0.01321505,0.072120145,-0.04315439,-0.02740475,-0.06747315,0.028061107,-0.012643911,-0.021772666,0.009277663,-0.019648483,-0.018011805,0.078086846,-0.09356147,-0.02015206,-0.07473136,-0.16894028,-0.022862013,0.046253975,0.062014617,-0.02983819,0.05326351,-0.05839927,-0.018127767,0.033473194,-0.01691154,0.05121573,0.007484242,-0.065645255,0.007918992,0.038613275,0.038508177,-0.0066661225,0.00603062,0.08966386,-0.028662002,0.0515013,-0.048795637,-0.060641695,-0.020053709,-0.13049814,0.040007744,-0.0036587806,0.09481427,0.012907502,-0.05101658,0.024415672,0.05441596,0.025231903,-0.07984373,-0.090238616,-0.0077041923,-0.0693783,0.08846007,0.018959757,-0.0091356775,-0.036045354,-0.03196037,0.038977984,-0.024810428,-0.009669761,0.048526958,0.030038835,-0.080877006,-0.069902,-0.011286136,0.019186921,-0.048179027,0.09369638,0.04968817,0.015936716,-0.006076974,-0.13948497,3.8939573e-33,0.09333407,0.019243915,0.018173419,-0.018263647,0.007893308,0.008887307,-0.09672012,0.06043327,-0.03365116,-0.045754436,-0.04657189,-0.021511417,0.046041757,-0.063794926,-0.024454447,0.09179214,-0.03847781,-0.037589714,-0.0449106,-0.009296986,0.009050224,0.086411275,-0.02296924,0.052220777,0.020233773,0.046046015,-0.042194203,0.01802848,0.0022253762,-7.909389e-06,0.093162484,-0.14768837,-0.123563886,0.02151111,0.056567598,0.03509691,-0.057407018,-0.037356403,-0.021462716,0.023779381,-0.056518145,0.057854965,3.666376e-05,0.0039447513,0.041956495,-0.05434547,-0.019922018,0.10380569,0.061415497,0.090628035,0.023348546,-0.024697775,0.09172292,-0.05936883,-0.0545998,0.07889648,-0.006287366,0.02132345,0.0045981454,0.08333267,0.040302057,0.0707556,-0.026080167,0.06011661,-0.04847724,0.014496678,-0.061529618,0.009413454,0.06511696,0.08379725,-0.023215557,0.01830598,0.03751024,0.06635399,-0.015024903,-0.059841935,0.014378369,-0.04079608,-0.0037008622,0.00538194,-0.041123997,-0.037055127,-0.043903578,-0.03974031,-0.06995675,0.047698084,-0.00032302662,0.0051872605,-0.007330053,0.04817796,0.052212305,-0.02610533,-0.027234158,0.010193881,0.03573677,-5.986271e-33,0.09774603,-0.0682145,0.04303213,-0.12060104,-0.0111866975,0.077225216,0.028814977,0.0068510748,-0.011974729,-0.07523228,0.0787348,0.06797309,0.05907623,-0.0034663398,0.06646722,-0.015994996,-0.013955429,0.014074602,-0.0080568995,0.03676117,0.029093672,0.07801016,-0.023824874,-0.04692796,0.044337794,-0.032882754,-0.02268083,0.07668247,0.010163781,-0.0025018984,0.014678132,0.044469927,-0.036113195,-0.038194824,-0.04896059,-0.0021868981,-0.03507538,-0.020482609,0.027151491,0.04605214,0.016436012,0.05394652,-0.060149536,0.0025362042,0.06329611,0.056940835,-0.080914296,-0.008599752,0.034920342,-0.065264635,0.021439571,0.04813433,-0.018333897,-0.0035880655,0.011351142,0.026705677,-0.05157265,0.0590586,0.014714273,0.029748542,-0.03651741,-0.077719286,0.033668377,0.02434674,0.044933148,0.008654758,0.018534627,0.018501593,0.016614309,0.014013477,0.053085506,-0.009925537,-0.034020383,0.03674431,-0.044706322,-0.088871285,-0.058666814,0.040403903,-0.041006178,-0.042593867,0.03321631,0.0031312222,0.02507078,-0.06108886,0.010548771,-0.034351178,0.035003122,0.040647816,-0.01887584,0.004593169,-0.027483752,0.020240638,-0.06981581,0.038999677,0.019630302,-4.5039044e-08,0.051587388,-0.0065180156,0.022521557,-0.069023,0.04785777,0.043852795,0.023969406,-0.015043503,0.027224895,0.005590521,0.022765223,0.114795506,0.012019374,0.034459002,0.045154624,0.015246269,-0.09678737,-0.0102264285,4.9491624e-05,0.031813424,0.021977648,-0.023031842,-0.11850524,0.038439512,0.011137259,-0.03061288,0.031365305,-0.03208662,-0.011681294,-0.048635073,-0.013943372,0.03308168,0.08456469,-0.060723405,-0.048302595,0.03254028,-0.06064833,0.022397831,-0.07217116,0.062305406,0.032979883,-0.08568305,-0.022957891,0.0042334134,-0.008657591,0.038696904,0.088596694,-0.027275883,-0.018279707,-0.040056452,0.022640478,-0.006473858,-0.007428339,-0.08933942,-0.100489564,0.004467824,0.005457758,-0.057521783,-0.05479899,-0.044037033,0.08671335,-0.022668367,0.1367375,0.0050980514 +1.1.1.383,"The enzyme, characterized from the bacteria Hydrogenobaculum sp. and Syntrophomonas wolfei subsp. wolfei and from the archaea Metallosphaera sedula and Ignisphaera aggregans, can use both NADH and NADPH with similar efficiency [cf. EC 1.1.1.86, ketol-acid reductoisomerase (NADP+) and EC 1.1.1.382, ketol-acid reductoisomerase (NAD+)].",384,1.0,-0.06473954,-0.037237316,-0.09734074,-0.021124776,-0.010498459,0.04429886,-0.0878195,0.028370138,0.055596728,-0.02193323,-0.030456185,-0.051709257,-0.07634887,0.015275927,-0.037331257,-0.0031819772,-0.004944376,0.018133158,0.013668255,-0.04824169,0.045567513,-0.0074752565,-0.021351054,-0.02391352,0.056007266,0.03548588,-0.03453777,-0.03428715,-0.060107306,-0.082903385,-0.050801173,-0.07998565,0.03338618,-0.08796035,0.057063658,0.07632383,-0.06081582,-0.030648736,0.0035312623,0.006334776,0.047812406,0.011667186,-0.007792584,0.012553212,-0.061030015,-0.028849239,0.016428571,0.07793217,0.084017105,-0.028481001,-0.045306083,-0.0632188,-0.018225987,0.032337718,0.08996882,-0.02687799,0.02240507,-0.03626394,0.011764611,-0.07289388,0.012013452,-0.025990274,0.020707142,-0.02867879,0.0062345397,-0.057910774,0.08723238,-0.046270635,-0.03951002,-0.02515121,-0.14686638,-0.0009267857,0.0074121105,0.032982185,-0.01942765,0.04885534,0.0017831177,-0.01522338,0.08163803,-0.017513886,0.020015324,0.06833741,-0.059596818,0.015574648,0.032883897,0.04321805,-0.009530594,-0.007957219,0.04322765,0.0011021671,0.02595183,-0.027432105,-0.01122208,-0.109260514,-0.12250234,-0.009115514,0.02332591,0.06129273,0.038825493,-0.058107544,0.017696368,0.06939046,0.022179903,-0.100545846,-0.101809345,0.0068823304,-0.05292264,0.14145713,0.064529404,0.029003607,0.009668996,-0.01586375,-0.011852619,-0.004726382,-0.012420574,0.053599726,0.019953853,-0.04482773,-0.080047384,0.0032652286,-0.02341118,-0.030280272,0.05405385,-0.0047660093,0.030003335,-0.026498906,-0.14140648,3.7221944e-33,0.11150219,0.025005857,-0.031997565,-0.031451233,0.04450974,-0.01657321,-0.09625931,0.05416791,-0.005590573,-0.019320859,-0.06000047,-0.06125437,0.04037186,-0.056424316,0.039266475,0.069700055,-0.011332985,-0.031469166,-0.06901552,-0.0037307367,0.033689808,0.0533649,-0.0027573335,0.01073249,0.05229963,-0.003892278,-0.01988848,-0.0011006602,0.0063182903,-0.017849669,0.07285864,-0.115797795,-0.14457102,0.03014667,0.10684092,-0.029284993,-0.02951569,-0.035372313,-0.017946525,0.011606154,-0.06398625,0.09523796,0.013033056,-0.0352014,0.07843869,-0.06129324,-0.023818742,0.09948042,0.07155903,0.046272818,-0.005763266,-0.014251945,0.1165044,-0.02822933,-0.019911412,0.094646394,-0.005142239,0.034816116,0.061541934,0.10267559,0.00030089158,0.074640065,-0.021956448,0.031812344,0.002874419,0.049555223,-0.07841588,-0.021370439,0.06950332,0.08625301,0.0068984847,0.02462813,0.000713531,0.04427444,-0.0055592563,-0.084174804,-0.008070477,-0.04401005,0.02678256,0.00846966,-0.023528572,-0.054564428,-0.03074849,-0.0042293556,-0.037311714,0.058565024,-0.009571012,0.011466468,-0.04233183,0.027616208,0.095167615,-0.040038224,-0.0017909735,-0.06619432,-0.015837599,-5.088715e-33,0.13255887,-0.07916928,0.05047845,-0.121130966,-0.039261624,0.094024606,0.004916868,-0.030067114,-0.07184401,-0.09134195,0.066191025,0.11608663,0.07215821,0.047537915,0.046720117,-0.028434042,-0.009904432,0.027847786,-0.004113584,-0.015183159,0.028791737,0.061264712,0.006859175,-0.047782626,0.041258227,-0.09196217,-0.05540718,0.1333454,-0.017239148,-0.010490284,0.0016598915,0.036963608,-0.05228281,-0.11445274,-0.034937624,0.018475085,-0.055709373,-0.023830421,0.0029157805,0.05546089,0.05584612,0.006540464,-0.068938576,0.04735202,0.045548026,0.05774066,-0.14835119,0.0051518246,0.04672461,-0.0033330263,0.0551165,-0.02181964,-0.044191796,-0.043303013,-0.006056786,-0.029792031,0.0069484683,0.035514586,0.027347757,0.018540235,-0.05786174,-0.053421725,0.06885662,0.06974344,0.046946745,0.01878845,0.032015834,0.0035592075,0.025346754,0.0101811765,0.03997848,0.008137208,0.020974759,0.06215181,-0.009368991,-0.06387178,-0.011475832,0.023441335,0.010007393,-0.03904582,0.015487392,0.010606376,0.0030270107,-0.05905253,0.045387503,0.001906181,0.044791725,0.0278712,-0.060326837,0.04241738,0.019916536,0.015394739,0.010680736,0.05748924,0.015097279,-4.5086058e-08,0.04847953,0.007855771,0.052492592,-0.03312601,0.029174417,0.067327,0.015976494,-0.009667113,0.024420785,0.015689464,-0.010284755,0.09457578,0.026597938,0.014832153,0.047277614,0.017350923,-0.016111791,-0.015225893,-0.015564368,-0.0010574567,0.019941315,0.0037583788,-0.11494063,0.07202777,0.026605401,-0.053539068,0.031084098,-0.016084293,-0.04420539,-0.09261963,-0.027077096,0.059187524,0.081493765,-0.022542005,-0.043057,-0.003982479,-0.08575866,0.05622826,-0.058365237,0.038906135,0.005009561,-0.043502495,-0.04091166,-0.009347917,-0.027188811,0.01505339,0.03848416,-0.010965919,-0.007036535,-0.04604806,0.067764156,-0.01768601,0.035080086,-0.06483856,-0.06319243,0.021846712,0.011137929,-0.07369967,-0.041144103,0.010000964,0.09740354,-0.050084885,0.069721766,-0.032041676 +1.1.1.384,"The enzyme is involved in the biosynthesis of several deoxysugars, including L-digitoxose, L- and D-olivose, L-oliose, D-mycarose and forosamine.",384,1.0,-0.09623909,-0.018644104,-0.06326073,-0.00050369586,0.0265855,-0.017535595,-0.08707689,0.024177099,-0.01275743,0.046197023,0.00940116,-0.049210176,-0.06646777,-0.021553807,-0.02015039,0.11183624,-0.07687073,-0.0085713705,-0.010211349,0.0045278356,0.10838063,0.03940114,-0.047193993,-0.0044490118,0.050814986,-0.03268939,0.015979316,-0.0024782228,-0.010051843,-0.056578077,0.00058191904,-0.089685835,0.08779864,-0.033501018,0.0255065,0.0532717,-0.0469805,-0.0339716,0.062696636,0.061399426,0.023123974,0.005906826,-0.03959846,-0.00417104,-0.09387964,-0.06500015,-0.0747149,0.01772846,-0.037398193,-0.013369839,0.00036329302,-0.03094338,-0.084301256,0.016349824,0.01853444,-0.029940216,0.018481368,0.008961064,-0.07037216,0.011735187,0.068533175,0.068102375,-0.03777703,0.0366587,-0.018040678,-0.05501195,0.056964956,0.014310551,-0.020242471,-0.07953805,0.010081525,-0.08601978,0.024704376,0.003968732,-0.038746327,0.017413814,0.028638424,0.0035073995,0.009822463,0.0077756783,0.08332787,-0.009374513,0.014852161,0.041918024,0.0141902445,-0.0050964556,-0.002502254,0.024478586,0.049026944,0.028760808,-0.012716068,-0.119765356,-0.059220485,-0.03079819,-0.051559974,-0.021277498,0.09611093,0.07745813,0.023633348,-0.044005297,0.009819113,0.023132939,-0.027030664,-0.08128838,-0.046951212,0.010326602,0.014074527,0.061641335,0.03737872,-0.0064229993,0.033517845,-0.0023988036,0.11571897,0.10506845,-0.05458395,0.079813674,-0.029819455,-0.10093081,0.024042586,-0.028073406,0.07832212,0.005796896,0.056365274,0.04709053,-0.046601605,0.061705735,-0.07439875,-1.7274733e-33,0.062219042,0.028870659,-0.05665687,0.006260266,0.004747308,-0.025256542,-0.10371748,0.024098018,-0.07138322,0.011295512,-0.120848075,-0.062381722,0.06839552,0.058012716,-0.016537726,0.010535575,-0.011543771,-0.027659588,0.048035473,0.049824383,-0.022410711,0.028098768,-0.11665231,0.02171726,-0.0033507345,0.104512274,-0.051200874,-0.013287202,-0.01905615,-0.006706484,0.049645063,-0.12935056,-0.062357616,0.012532526,0.068767,-0.027868709,-0.030956315,-0.054068483,-0.037261937,-0.037553556,0.0175278,0.007311102,-0.03475739,-0.029006466,0.0557013,0.020849347,-0.024998125,0.07314205,0.056823045,0.07426876,0.048634026,-0.02536391,0.05466562,-0.023879664,-0.06891805,0.034923203,-0.026337247,-0.06546039,0.044680346,0.052925184,0.012842914,0.01955878,-0.025132691,-0.006268544,0.06819993,-0.016826697,-0.01764073,0.011180655,-0.01835866,0.04151676,-0.100923054,-0.08903925,0.038266607,-0.04583308,0.062483236,0.010009807,0.0032896418,0.03157742,-0.025829183,-0.026520614,0.08763161,0.0041703107,-0.04074498,-0.059543177,-0.0072660884,0.016506407,-0.007450219,-0.03808089,-0.017357463,0.093195766,-0.0073517845,-0.07205918,-0.062380888,-0.04032232,0.022412498,-1.3144935e-33,0.019478187,-0.07218149,0.06620564,-0.09318326,-0.036631197,0.108626835,0.03269729,-0.019710464,0.03628134,-0.0418126,-0.0043645804,0.02477609,0.03237993,-0.046418753,0.012633236,0.06030192,-0.07285386,0.03668299,0.006606553,-0.037661873,0.027331866,0.08688492,-0.03304535,-0.023705535,0.0890566,-0.0078032,0.02092996,0.06486256,0.09931619,0.022636708,0.0026389395,-0.015181442,0.025981005,0.006914873,-0.052988,0.07257489,-0.05996417,0.019005464,0.01552358,0.032502312,-0.050251015,0.013250484,0.029139332,0.03279837,0.013300942,0.02959371,-0.14977965,-0.041019693,-0.0047525885,-0.008009486,0.038778026,0.031603884,-0.008534516,0.013777508,0.015729072,0.044274744,0.0041030436,-0.02401342,-0.0022573057,-0.028666005,-0.019327236,-0.048818257,0.029849706,0.025160912,-0.004821834,0.028540077,-0.036961917,0.027759247,-0.016136942,-0.03781092,0.06693055,0.0147081725,-0.037656404,0.021796042,-0.018207263,-0.057758585,-0.13918163,-0.036382005,0.0122426925,0.010235718,-0.020694343,0.009383417,0.08485162,-0.01940911,-0.06233945,-0.060419142,0.031540047,0.13938561,0.036554616,-0.011264021,-0.0088071665,0.0074175606,-0.037658263,0.033348847,0.10174222,-3.58338e-08,0.018931381,-0.08648727,0.044996962,-0.032695465,-0.039496668,0.017564083,0.024957985,0.012203294,-0.019668166,0.03246702,0.050054874,0.115165256,-0.06391651,0.016647644,0.07393748,0.00308909,-0.0026236463,0.024413353,-0.018081577,0.07901477,-0.025202971,-0.004999145,-0.094072774,0.0222074,0.017593365,-0.06503926,0.017850937,0.047323704,0.07978375,0.010866299,-0.0012334924,0.05678632,-0.012362281,-0.112367235,-0.11885519,0.015841378,-0.062947586,-0.07655802,0.027274877,-0.013303551,0.03381465,-0.056104355,-0.031354375,0.055556256,-0.021626256,0.0032246236,0.039245874,0.010123069,0.0074023535,0.019103697,0.014150403,-0.019819085,-0.043326218,-0.04764306,-0.10186856,-0.016137717,-0.032647062,0.018830081,-0.015960747,-0.009402364,0.018317847,0.12581486,0.23181537,-0.08271966 +1.1.1.385,"The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. ",384,1.0,-0.054114148,-0.043262508,-0.076806754,0.0040784767,0.045104705,0.029596783,-0.07769043,0.058457904,0.04288337,-0.0015421248,-0.0050192787,-0.042066474,0.044441357,0.04008682,-0.09961491,0.034633495,-0.09337516,-0.013609543,0.008343253,-0.00911404,0.01983062,0.081035785,-0.010782381,0.008028047,0.06289524,0.014254041,0.05796092,-0.026410054,0.053108677,-0.044574328,0.020681264,-0.048884045,0.09165112,-0.13893998,0.057807427,-0.0069052414,-0.03255201,0.011733752,0.19245535,0.025359504,-0.041254852,0.038753934,0.0034811632,-0.07547501,0.0047300276,0.037569266,0.044095803,0.004272752,0.020513665,0.06753663,-0.03142497,-0.0084637785,-0.021096837,0.0053493343,0.019542657,-0.027087213,-0.109340176,-0.036940657,0.02330828,0.026269149,0.016404059,0.0053698933,0.08261084,0.005100206,-0.05895422,-0.008989324,-0.023171823,-0.05516615,0.05270139,-0.043652788,-0.11281906,-0.06032527,-0.015922705,0.04898762,0.06293691,-0.0044401917,0.026540123,0.045924135,0.003748306,-0.044361923,0.059914853,-0.059474003,-0.023016289,0.12235638,0.020920625,-0.015914934,0.055426754,0.0020479918,0.07649269,-0.05386841,0.01839824,-0.04147589,-0.014082317,-0.08933085,-0.025933934,0.008224277,-0.08085868,0.014210303,-0.0077487156,-0.02954697,-0.021319307,0.07128814,-0.025552757,-0.056714308,-0.027079344,-0.07454753,0.06018048,0.0879653,0.03321229,-0.030331459,0.08312453,0.036862947,0.013177514,-0.056726072,-0.058228925,0.046874914,0.066546455,-0.03639187,-0.052278403,-0.055552945,0.053647548,0.006402395,0.0235039,0.04493198,0.0065391576,0.027720587,-0.050845806,1.9159002e-33,0.05607728,0.059593637,0.006621186,-0.010441109,-0.017019086,-0.07820748,-0.062691316,-0.0010451017,-0.03531207,-0.012113707,-0.064796284,-0.088678576,0.034275357,0.095401004,0.077719495,0.02721803,0.061148766,-0.04080754,0.04677974,-0.026910136,-0.027712682,0.051565707,-0.009048143,0.052854594,0.0633759,0.07896426,0.09142556,0.041279607,0.07698381,-0.03122524,0.0111324005,-0.020264657,-0.07887081,0.01187641,0.06296546,-0.07294695,-0.0697205,-0.012054585,0.048402093,0.09435351,0.036237083,0.068741806,0.0053478777,-0.03423132,0.04770164,-0.0062790946,-0.020098684,0.0745342,0.05762767,0.031368997,0.022485657,0.005554724,0.088570006,0.0061138617,-0.011315647,0.030517241,-0.002787768,0.053818807,0.0015655117,0.0560809,0.002064645,0.007102029,-0.028128989,0.03992126,-0.037488602,0.06373993,-0.0043004113,-0.015098378,0.018128876,-0.028742146,-0.062491827,0.0063340184,0.0025067942,0.051597632,-0.0514288,-0.027428832,-0.042012323,-0.021308728,0.060080305,-0.009202285,-0.0024983124,0.011757076,-0.025941906,-0.010665116,-0.03157403,-0.07565937,-0.023233417,-0.06466378,-0.0037081775,0.039022714,-0.049933076,-0.046940476,-0.059237465,0.069306836,-0.014472492,-3.1960387e-33,0.08108963,-0.12440212,0.023477362,-0.105311096,-0.13248396,-0.0016995085,0.0020969112,-0.062198635,0.023841366,0.014020914,-0.0082591595,-0.018070213,0.032667518,-0.022353724,-0.037161995,0.01604213,0.050128713,0.03403006,-0.013538952,-0.022683017,0.018974548,0.08326711,0.088822804,-0.11092401,0.06517163,0.05756313,0.013842386,0.09937231,0.034484427,0.024383275,-0.030703502,-0.008042879,0.0024546988,-0.08059127,-0.10828176,0.09186448,0.020496795,-0.024431858,0.026172642,-0.06355771,-0.0029111379,0.009135805,-0.006131385,0.045375906,0.058194976,-0.01770358,-0.054471698,-0.029439263,0.008228413,-0.12658627,-0.047229122,-0.014442308,0.10281158,-0.015645003,-0.018066052,-0.024801617,-0.055785373,0.0068544117,0.052168675,-0.075169355,0.008796981,-0.085723475,0.040919237,0.0005640212,0.013742299,0.11072522,-0.029417146,-0.021009384,0.035792153,-0.095801204,0.0541021,-0.056161575,0.061903898,0.055944547,-0.049210902,0.030056765,-0.047523815,-0.086401455,0.0053205164,-0.051673472,-0.053340062,-0.03513171,-0.052615393,-0.008323613,-0.058453057,-0.029073872,-0.048022002,0.085463084,0.012873223,-0.0016279295,-0.0195414,-0.0057518478,0.010903038,0.069399856,0.045475062,-3.3073743e-08,0.06322305,-0.054217745,-0.013505031,-0.029282248,-0.030437194,0.07595847,-0.040310256,-0.0704054,-0.03915166,-0.053728856,-0.041579705,0.02691262,-0.05829435,-0.008506399,0.004946393,0.055628426,-0.06915733,0.011819553,-0.011056852,0.045834746,-0.028029678,0.020951428,-0.08554225,0.034627035,0.0010577203,-0.081356384,0.008546964,-0.08054449,-0.022861736,-0.02618389,-0.0050280597,0.042206604,0.011131956,-0.05193488,-0.044993445,0.0019907537,-0.081336744,0.024326488,0.036945477,0.013094037,0.07893635,0.04036225,-0.1359218,0.012182227,-0.0116208,0.029024618,-0.02964706,0.066965446,-0.026994362,-0.022083078,0.030329803,-0.023359561,0.02859179,-0.008093505,-0.115123674,0.03893268,-0.008375192,-0.040748347,0.024204211,-0.024706686,-0.03140365,0.03486814,0.14552741,-0.0010070472 +1.1.1.386,"The enzyme is involved in pheromone production by the pine engraver beetle, Ips pini. ",384,1.0,-0.047358267,-0.05675506,-0.030277671,0.053959884,0.034971528,0.021365443,0.018946758,-0.029439589,0.016607752,0.017497592,0.039460372,-0.016107865,-0.10761906,0.025434846,-0.054722,0.06682632,-0.024032753,-0.052143227,0.015557625,-0.020407634,0.11549465,0.022124315,0.017209694,0.0027106027,-0.09058841,-0.0838674,-0.028038139,-0.045097362,-0.03547784,-0.046977285,0.044284873,0.057628866,0.08302001,-0.032991372,-0.082105,0.058313955,-0.037167188,-0.09514641,0.15485278,0.05076183,0.041056667,0.0094175665,-0.01776491,-0.07743352,-0.120710984,-0.018598048,0.049758375,0.048618723,0.05679471,-0.05259944,-0.04898246,-0.0778256,0.026670873,-0.0051699462,0.014471346,-0.005942406,0.06549533,-0.12669691,-0.029300774,0.017482022,0.03980318,0.08608984,-0.040559173,0.008207694,0.05084199,-0.045635775,-0.0800885,0.022005662,0.031762686,-0.086186685,0.003907506,-0.033287857,-0.085753374,0.016944392,0.057329904,0.018918784,-0.07963112,-0.007628915,0.05816725,-0.056587525,-0.083609276,0.0052508917,-0.008577471,0.070112534,0.03017667,0.057080258,0.013983213,0.081937775,-0.0028005466,0.031176338,0.03630604,-0.06316504,-0.08390178,-0.0104920305,-0.0071064406,-0.012257424,0.03641146,-0.047648497,-0.0651853,0.018487157,-0.031422034,0.026965016,-0.05730915,-0.14160632,-0.07340706,0.021587782,-0.045528814,0.057995908,0.05092311,0.008629814,-0.007141697,-0.04842459,0.05632273,0.034606624,-0.015854739,0.015846118,-0.024599139,-0.05161621,0.07077041,0.056336936,0.038477927,-0.0054456727,-0.0015915795,0.05815191,-0.02281816,0.010941974,-0.13148728,-1.9716804e-33,0.033081852,0.05674599,-0.028246785,-0.033057764,-0.011742539,0.03848708,-0.059657745,-0.038519487,-0.0046031484,-0.038063344,-0.07638338,-0.044510186,0.0049784863,0.012539552,0.026172893,0.016128685,0.040076982,0.053604938,0.0821418,0.015695538,-0.05641688,-0.04559615,-0.10594999,-0.054009184,0.05525708,0.09968174,-0.043790568,-0.029022371,0.04031839,-0.0018850849,0.1478666,0.018602949,-0.059207823,0.02609356,0.057042666,-0.016849583,0.00044772192,-0.08708491,-0.054011557,-0.015606433,0.04979906,-0.015689967,-0.008891192,0.025635686,0.02545743,0.0159034,-0.12750414,0.06826609,0.1023059,0.06510035,0.0367529,0.040513095,0.13349016,0.0017942255,-0.020510517,0.027582932,0.0034144053,-0.055868864,0.015326837,-0.0404945,-0.0563848,0.037857804,-0.004807379,-0.0017200706,-0.0007752931,0.0099295005,-0.030632282,-0.017444663,-0.063402295,0.12015801,-0.04597633,-0.057957646,-0.04027088,-0.06606099,-0.025338683,-0.00050459936,-0.028539343,0.009128263,0.006584496,0.012354805,-0.04405634,-0.007935484,0.02105177,0.0027149199,-0.04232199,0.007783885,0.013150191,0.001543842,0.023234354,0.06996889,0.04819855,-0.051730856,-0.05423345,0.0019632543,-0.023316845,4.6489475e-34,-0.0475527,-0.104825586,0.020126455,-0.060400505,-0.031778634,0.060800888,-0.016852023,-0.02116794,-0.030039113,-0.00089554547,0.023081994,0.04808824,0.014760495,-0.026191253,0.038260385,0.01616959,0.03306928,0.10419591,0.051014856,-0.018348966,-0.029095516,0.061626922,0.0013114534,-0.028293008,0.011364514,0.005328016,0.079116456,0.114841595,0.021371221,-0.042499024,0.09544427,0.014357367,-0.03819038,-0.055694412,-0.0008118168,0.03570467,0.00551127,-0.0379873,0.08760489,0.0504131,-0.0029874423,0.0013472766,0.052065954,0.056371756,0.014756545,0.02455678,-0.082150385,-0.012367457,0.014830367,0.011909617,0.07657699,0.029906012,0.010085641,-0.0628688,-0.06592032,0.030387435,0.029770272,-0.0048234006,0.02736441,-0.1024731,-0.062454216,-0.039692473,0.029128619,0.08972332,-0.07110223,0.018014882,0.024351997,0.037183315,0.047243036,-0.013524657,0.08641945,0.079819106,0.0804345,0.07120309,-0.037770517,0.014796664,-0.007282235,-0.055802595,0.009596719,-0.021802565,-0.015329391,0.021624783,-0.016396455,-0.046935175,0.0069458387,-0.060667362,-0.018676944,0.11250902,-0.028700134,-0.02096795,0.0059264917,0.034710303,0.0095649455,-0.029452423,0.07775327,-2.183901e-08,-0.015661983,-0.04509859,0.00931886,-0.048546348,0.00622101,0.018911466,0.019763282,-0.05199123,-0.050148018,-0.030056281,-0.004527707,0.056126427,0.013019075,0.023433447,0.112617865,-0.036278963,0.0073676514,-0.02217875,-0.038041707,-0.020798622,0.022030827,0.043075256,-0.0561996,0.056046654,-0.06326277,-0.057668652,0.07662708,0.014606226,-0.021336546,0.0043057846,0.050099507,0.11607947,0.02116041,0.02364557,-0.051905867,0.06588403,-0.056543775,-0.013386886,-0.0133939115,0.0035290448,0.019206492,-0.039441187,-0.055842627,-0.059236836,-0.01629716,-0.04556604,0.052555036,0.04395199,0.011076885,0.02942178,-0.0037004906,0.11340164,-0.010074278,0.022219611,-0.07495794,-0.06739792,-0.0010304517,-0.10487945,0.020865036,-0.011047036,0.085396335,-0.043869115,0.12482621,-0.027824353 +1.2.5.2,"Wide specificity; acts on straight-chain aldehydes up to C10, aromatic aldehydes, glyoxylate and glyceraldehyde. The enzymes contains a PQQ cofactor and multiple hemes that deliver the electrons to the membrane quinone pool.",384,1.0,-0.05450194,-0.028496763,-0.05933274,-0.056189474,-0.015201203,0.06772082,0.011034104,-0.02209959,0.03122692,0.012583824,0.02276121,-0.059655648,-0.08537667,0.07466949,-0.02037338,0.049256906,-0.05480297,-0.047845524,-0.04832225,-0.055648305,-0.004666194,-0.010014345,-0.051831674,-0.04142022,-0.005867674,-0.010484246,0.05771738,0.010629167,0.012121871,-0.061755486,-0.03990167,0.024405308,-0.03082567,-0.011487357,0.048326243,0.059976768,-0.059274577,-0.028848635,0.059183136,0.02440356,0.07287576,-0.0005059467,-0.0055753086,-0.024793727,0.040470958,0.0053921016,0.040773995,0.055737477,-0.054709304,0.024056846,0.017352032,-0.049478784,-0.04842626,0.074384026,0.06089717,0.05602053,-0.08184859,0.05431743,-0.014729986,0.03350391,-0.0067711025,0.025620861,-0.003309017,0.025853392,-0.0004446722,-0.075959876,0.023260761,0.0011037493,0.029519582,-0.08381255,-0.08538926,-0.06923224,-0.07676513,-0.063778244,0.08109153,0.043352284,-0.08024707,-0.0074223396,0.024590146,-0.02031631,-0.0042219334,-0.020120205,0.07431214,0.105851,0.065467216,-0.0077471617,0.009317247,-0.0038984066,-0.049792044,-0.023436379,0.047272682,-0.065495215,-0.028039623,-0.0488372,-0.012239348,0.09786574,0.03905676,0.012397788,0.05618419,-0.018092051,0.03579917,-0.018121345,0.018971665,-0.028102411,-0.07333394,0.047209933,0.04809294,0.10493117,0.059880808,-0.060336318,-0.028213367,0.010251883,0.08620129,-0.06704103,0.009426711,0.033011876,0.06687875,0.007296783,0.043196455,-0.037376955,-0.042512625,0.023725307,0.018087849,0.028935712,0.008826944,0.07522368,-0.07355696,4.3372832e-33,0.09386642,0.0023903872,0.057539098,-0.021160955,0.0038303116,-0.037767462,-0.06806648,-0.0052148188,-0.094022036,0.03007505,0.015347487,-0.036097363,0.04279405,0.023889706,-0.044525657,0.04544248,-0.15007712,-0.06877294,0.03630781,-0.0058817468,0.0024342944,0.021532305,-0.0780215,0.031798124,0.06028531,-0.0028020972,0.015716238,0.041553542,-0.037902363,-0.024519952,-0.00042961794,-0.016919212,-0.07259306,-0.02098494,-0.0787417,0.07224321,-0.08662513,-0.025584418,-0.022053646,-0.008856887,0.0030144288,0.0054552215,0.018481737,-0.08122642,0.00045922652,-0.04537193,-0.05182326,0.041867226,0.003393634,0.043060113,0.0480523,-0.037296496,0.05487049,0.01778765,-0.09485057,0.052042253,0.01635282,0.023522962,0.06953441,0.05396208,0.060468636,0.028337833,-0.10049151,-0.027990421,0.044535417,0.07164613,-0.024428898,-0.026553746,0.00987118,0.10455451,-0.05549225,-0.0400922,0.08070223,-0.06652567,0.015974997,-0.04930955,-0.08418909,0.0009687529,0.061490875,-0.0060422206,0.005709026,-0.031495996,0.09786142,-0.014010077,-0.09077616,-0.11979575,0.015905898,-0.05419206,0.0016611556,0.005488734,0.008886528,-0.025332931,0.006637438,0.03676981,-0.017156074,-3.918987e-33,0.05671362,-0.069848016,0.010936151,-0.060217947,-0.0034734963,0.015433655,0.005040364,-0.03642699,0.03246339,-0.03603521,0.092351034,0.06071495,0.010600484,0.010059627,0.030129738,-0.018977055,-0.007144954,0.022613807,0.054977678,0.017956477,0.019197814,-0.0020607426,0.0034187913,0.052923802,0.0954297,0.021504277,0.0102303615,-0.0040897233,0.11416656,0.055173125,-0.07345922,-0.035931073,-0.02376447,-0.03548561,-0.04423916,-0.036301937,-0.019524796,0.10049515,-0.018656213,0.012725581,0.01907841,-0.05142339,0.033156037,0.11896096,0.02972043,0.13539462,-0.13658541,-0.029874684,-0.085709006,-0.014031668,-0.0372759,0.106884874,-0.026019365,0.08830057,0.0024755122,0.108395554,-0.003282566,-0.037678007,0.03653622,-0.065191895,-0.118561186,-0.026261242,-0.01284835,-0.07674094,0.017476758,0.052947886,-0.06087191,0.012521476,0.02116303,-0.055366036,0.049371187,0.010292868,-0.011842882,0.0065401234,-0.04837501,-0.07167151,-0.021039996,-0.04456442,0.03253042,0.07379445,0.07193757,0.004144802,-0.02953784,0.0027968683,0.027351664,-0.06830226,0.007931173,0.1261608,0.010282537,0.03578894,0.014825654,0.012716631,-0.0072063785,0.045231465,0.016129935,-3.8047318e-08,-0.05101227,-0.034461617,0.036292356,-0.020027177,-0.03960687,0.041380804,0.094851375,0.086991265,-0.016300581,0.043719023,0.039006483,0.029084576,-0.02120017,0.014833683,0.06452211,0.052073427,-0.09738051,-0.02351994,-0.034108244,-0.035045467,-0.0905848,0.0059238714,-0.07458721,0.048324764,-0.014551197,-0.033198036,0.00061127497,0.009396616,-0.071053,0.038910322,-0.026935639,0.065653734,0.010501317,-0.021091403,-0.07699192,0.017468698,0.008958707,-0.041510053,-0.015014729,-0.024267696,0.0033675656,-0.07295036,-0.068830274,-0.016185997,0.03245342,-0.030175624,0.0031279358,-0.023296658,0.016591843,0.054123383,0.09540323,-0.01256305,0.033748347,-0.0332352,-0.10639953,0.019266007,0.01500564,-0.04623686,0.02742432,-0.053757966,0.057157073,0.031042142,0.21537404,-0.004127168 +1.2.98.1,"The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein) [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2].",384,1.0,-0.09105136,-0.00010693185,-0.05918497,0.0035376363,0.079575114,0.007033696,-0.07275523,0.015933448,-0.0120285,0.030622896,-0.04956438,-0.028131235,-0.061398145,0.016053187,0.019706886,0.036933497,-0.0029890167,0.005502988,0.029206265,0.04197752,0.03554281,0.052566558,-0.009188184,-0.07112813,0.058061555,0.038652383,0.06432845,0.049376298,-0.03645006,-0.0675142,-0.023225855,-0.044769,0.012294749,-0.057798702,0.10910754,0.040450204,-0.048994385,-0.05506073,0.012520323,0.018190335,0.06616998,0.054131873,-0.027242707,-0.00791028,-0.0099382615,-0.031019669,0.038597994,0.06392034,-0.06540721,-0.033733975,-0.068640105,0.0071267732,-0.004083728,0.006422081,0.04396339,0.009871875,0.023865595,-0.025015708,-0.012840771,-0.042499654,-0.012578593,-0.051522017,-0.03361159,-0.014304,0.06784428,-0.07855116,0.061784208,-0.051584505,0.063312344,-0.032761976,-0.11603871,-0.03464202,-0.012083602,0.026036212,-0.018651215,-0.0042705834,-0.065958075,-0.06062729,0.07984127,0.01723743,-0.04213195,-0.0018559215,0.018719293,0.08361705,0.0641383,-0.027614117,0.057592787,0.016330143,0.007861901,0.06601636,-0.0002123691,-0.029755265,-0.021452116,-0.009816685,-0.119191274,-0.001937516,0.12664118,0.10597656,0.061192814,-0.054116573,0.009766118,0.08784188,-0.0059469515,-0.091140255,-0.05234053,0.021399671,-0.00073200674,0.12382561,0.050895896,0.07445782,0.007261408,-0.021403102,0.046435583,-0.035901163,0.004391663,0.09115796,0.027686065,-0.083846845,-0.07259905,-0.03200184,0.004866809,-0.027922055,0.08513617,0.015761137,-0.0447169,0.055073295,-0.115623906,4.908658e-33,0.06435147,-0.009758163,-0.06128548,0.013033322,-0.003936397,-0.024647068,-0.08915582,0.07435377,-0.025956785,0.004910024,-0.025274102,-0.05300738,0.07183909,0.012730146,-0.07283928,0.046683617,-0.042540528,-0.08593377,0.021649946,0.07919474,0.007578625,0.0044914503,-0.029964998,0.050600126,0.008721261,0.03428677,-0.05099898,0.061511118,0.007573416,0.0061155753,0.06346977,-0.11560004,-0.057433225,-0.01523145,0.028968405,0.005626075,-0.061548334,-0.048426487,-0.022879994,0.009210464,-0.012756018,0.007967703,0.037303004,-0.01715146,0.037095923,-0.036390238,-0.038058806,0.059092816,0.005476694,0.030486489,0.02694615,-0.058438312,0.094374634,-0.079872526,-0.093631215,0.03218149,-0.0019064173,0.004516523,0.041513737,0.062402934,-0.005781544,0.074446894,-0.022590829,0.09632549,-0.04574162,0.016364023,-0.040713947,-0.0056076655,0.06371759,0.009908111,-0.03331511,0.04364244,0.04863967,-0.01676822,0.015111545,-0.02511856,0.0076452475,-0.0104099605,0.0706424,-0.01940243,0.020701896,0.009596178,-0.02081233,-0.049453724,0.013559477,-0.08317507,-0.06826799,-0.03127324,0.00022661556,0.036013536,-0.010201811,-0.09300775,0.0019107945,-0.011988591,0.005914756,-6.821559e-33,0.122539975,-0.06000261,0.0777482,-0.12565592,-0.047372907,0.060852088,0.0067014815,-0.03783217,0.05342306,-0.06541369,0.06814673,-0.005263429,0.1036137,-0.026535885,0.018715871,0.0020079976,-0.0627851,0.07375063,-0.040385403,-0.06885819,0.044312842,0.09329847,0.014046262,-0.03620486,0.0122559965,-0.012459467,-0.05577897,0.016240943,0.08368015,0.07404534,0.006745511,0.00024938423,-0.044680208,-0.08245515,-0.040553153,0.016058793,-0.08714341,-0.025225483,0.03206902,0.00073324965,0.015635625,0.005082784,-0.04652008,0.05049246,0.06320878,0.004853727,-0.13148163,-0.062051605,0.036123414,-0.045085397,0.02775517,-0.00069106324,-0.06876871,0.0036799214,0.035113715,0.06438325,0.017725997,-0.01374379,0.035598047,-0.00808958,-0.07337718,-0.050864697,0.06737362,0.0032811419,0.011697579,0.031271927,0.04344056,0.08060986,0.049296834,-0.027990365,0.06727916,0.030610096,-0.034712575,0.08128061,0.011403102,-0.05064956,-0.07218123,0.09910726,0.020680107,-0.006291809,0.035928145,-0.0054839263,-0.008352201,-0.035099328,0.013067187,-0.056474753,0.01784855,0.068205014,-0.049077008,0.02328381,-0.02392147,0.05131619,-0.0046716756,0.059583094,-0.027903348,-4.748529e-08,-0.0066790227,-0.032391615,0.12509501,-0.0012433358,0.039808083,0.06407441,0.021104503,-0.049771722,0.05416732,0.01854518,0.024845598,0.10288052,-0.008968241,-0.022138074,0.00022015772,-0.033691894,-0.10446026,-0.054147027,-0.068255655,-0.038935848,-0.074074276,-0.013462482,-0.03894763,0.085987516,0.04425293,-0.060130652,-0.011710147,-0.003727549,0.0016444676,-0.026590653,-0.046911504,0.07812398,-0.030015128,-0.06756576,-0.14995807,-0.043518137,-0.0066214595,-0.065435804,-0.036623724,0.039610576,0.039833914,-0.10554908,-0.07502259,0.013901617,0.030449683,0.014546779,0.0069323042,-0.033502053,-0.094009206,0.026503488,0.06166479,0.00057779736,-0.014197835,-0.005694482,-0.086606525,0.046413463,-0.010958824,0.013549461,0.0027557153,-0.04875838,0.05388834,0.01341593,0.12510692,-0.032304753 +1.3.8.12,"The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD. ",384,1.0,-0.119225405,-0.0655451,-0.09101984,-0.031027831,0.100236125,0.036217894,-0.116245665,0.03424319,0.015571943,-0.006484434,0.04569159,-0.10959462,-0.02372771,0.010882943,-0.023070397,0.017346907,-0.087484345,-0.0016623316,-0.017684702,-0.03136815,0.032035273,0.027378935,-0.081027254,0.0027658578,0.080869526,-0.0044231946,0.072843775,-0.05348589,-0.06410442,-0.023190422,0.045466613,-0.0011866125,0.045986716,-0.012113023,0.029143088,0.09954032,0.041689347,-0.03025498,0.08736301,0.044393506,0.0075863437,-0.03672637,0.02566003,-0.04465186,-0.07859162,-0.009521962,-0.020847116,0.045301877,-0.0040842206,-0.034166604,-0.038549803,-0.028511748,-0.103301734,0.008695229,0.058833074,0.05314391,-0.0012377683,-0.055214047,-0.015892226,0.0023801245,0.039263155,-0.031442687,-0.03213799,0.063942514,0.013473348,-0.07737974,0.029281002,-0.07264239,0.003295656,-0.025184665,-0.04663078,-0.026735403,-0.015013189,0.02940645,0.027802423,-0.0058488543,-0.0114858225,-0.06158827,0.053709406,-0.030104078,-0.018677466,0.05078068,-0.0024352402,0.04709797,0.032549232,-0.027433503,0.051033255,-0.013535041,-0.018218229,0.056000814,0.03571685,-0.018938955,-0.018174957,-0.088743456,-0.1327067,0.10612496,0.019330064,-0.050629675,0.02923096,-0.021433774,-0.03170332,0.08360699,0.006713174,-0.08130799,-0.088019125,-0.083512686,-0.06506615,0.10736546,-0.019368965,0.026821595,0.010042309,-0.032626018,0.012504822,-0.023771772,0.019693557,0.07765753,0.008305303,-0.10069014,-0.080355026,-0.0011232663,-0.056906886,-0.007848356,0.033398144,0.105163224,0.05955462,0.03436292,-0.09613756,5.0990635e-34,0.08180158,-0.0076424205,-0.04028392,-0.02416185,-0.011584387,-0.030140802,-0.07057689,0.05511904,-0.022455812,-0.046288755,-0.017360358,-0.01634071,0.014333156,-0.0107271485,-0.035308145,0.040418383,-0.041035306,-0.007838715,0.025325,0.030774936,0.03739399,0.017845737,-0.023373717,0.030198887,0.02063378,0.001831094,-0.035324663,0.034730863,0.04531504,0.01999969,0.010175357,-0.097503014,-0.06613338,0.009507198,0.02237026,-0.018800683,-0.034601655,-0.037718758,-0.025862204,0.054322045,0.08765965,0.021934813,-0.015365371,0.016362485,0.058736302,0.01222903,-0.046501942,0.055830304,0.049396753,0.08426044,0.048225563,-0.0269094,0.15895095,-0.0046927063,-0.048211228,0.027709134,-0.07733655,0.012839119,0.010870487,-0.013159523,0.03094302,0.08249763,-0.0014235278,0.08827385,0.041261062,0.01653328,-0.0025805142,-0.09139745,0.04418191,0.058090657,-0.022953339,-0.030572105,0.06370066,0.036666583,0.05495882,-0.06789566,-0.0017688664,-0.021707572,0.050927117,-0.013186861,-0.040147025,0.007905094,-0.008914585,-0.041754015,-0.011858282,-0.04717044,-0.028356712,-0.038355798,-0.019671503,-0.008605694,0.13193925,-0.070953995,-0.05050534,0.0168216,0.02994743,-1.6663865e-33,0.1255621,-0.15328287,0.032842875,-0.10934806,-0.033371173,0.08166271,0.054712277,0.021804815,0.035095204,-0.03900199,0.0986847,0.010367043,-0.02564158,0.03318055,0.039441872,-0.05358547,0.033420943,0.019182235,0.021297272,0.07035469,-0.043485925,0.020932246,0.098812915,0.013921459,0.08624388,0.0072358367,-0.059714563,0.06226395,-0.063654184,0.043290894,0.011100794,0.045055505,-0.060112536,-0.030815493,-0.12108858,0.045610502,-0.028420856,0.039540995,-0.021478675,-0.015527279,-0.035631035,0.02850997,-0.03616806,0.030628456,0.029386763,0.0054345117,-0.07413486,-0.00070581585,-0.026638662,-0.09799108,-0.033355996,0.038759913,0.010751759,-0.0032955136,-0.015648477,0.06821383,-0.023787998,0.04113605,0.014401742,-0.0773455,-0.071485505,-0.062127337,-0.016192373,0.026426986,0.085778125,0.107228644,0.018051066,0.08168045,-0.01471828,-0.00653203,0.09185679,-0.0015547017,0.020298405,0.06472562,0.0075778216,-0.08303371,-0.04843273,-0.015602812,-0.034755424,0.052112065,-0.012676004,0.027588297,-0.056763306,0.01151453,-0.085010275,-0.07567562,0.022173284,0.049575992,-0.010697582,0.0296662,-0.04010299,0.0336015,-0.01736004,0.03340256,0.08956339,-2.9361257e-08,-0.00033137866,-0.036137078,0.0648268,-0.024016773,0.099360414,0.029002722,-0.036321964,-0.031196408,0.032977138,0.019834945,-0.05165685,0.10641147,0.034739785,0.020287393,0.06396526,-0.0010803372,-0.03381623,0.008754155,-0.04039027,-0.0166073,-0.060361747,0.023057606,-0.08397662,0.063244715,0.055515952,0.014407485,0.05102547,0.0013904045,0.0023406926,0.0038612636,-0.018528523,-0.011648153,0.0078007355,0.031156566,-0.075168,0.038016748,0.019544015,-0.012258327,-0.07779005,0.03940433,0.012477265,0.008606941,-0.086033955,-0.020390417,0.048850827,0.04387793,-0.048150055,0.00942037,0.03050119,-0.038585614,-0.002726974,0.002670482,-0.04565028,-0.041651584,-0.11050507,-0.03204971,-0.03807633,-0.078661956,-0.047839474,0.030430678,0.023023415,0.09080068,0.12816879,-0.008091519 +1.5.1.49,"The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.",384,1.0,-0.03690512,-0.10560502,-0.14448959,-0.01565082,0.047966663,0.042512756,-0.06898225,0.05416464,0.03507767,-0.024451613,-0.055230595,-0.005404393,-0.074086405,0.010134928,-0.055485066,0.03855515,-0.058240954,-0.06784574,-0.008589924,-0.04814985,0.017809644,-0.0098932935,0.013358637,0.016993457,0.060001757,-0.009432977,0.035287984,0.06257078,-0.08323184,-0.042775795,-0.029812798,-0.014334276,0.008431363,-0.008311554,0.059106056,0.07710956,-0.056248344,0.012882211,0.07499661,0.026445994,0.0086112525,0.0039212294,-0.07147361,0.011099369,-0.058533162,-0.021727698,-0.014399531,0.057452038,0.03113702,-0.055987787,-0.05258238,0.0036872672,0.005270552,0.074050546,-0.08338398,0.025076931,0.037182245,0.028406085,-0.052184,-0.035656307,-0.06079249,-0.040435378,-0.010726842,-0.022713393,0.041258927,-0.046047553,0.0118431,-0.064171135,0.035622783,-0.068043694,-0.1340334,-0.038749013,0.050849676,0.022207184,-0.006583999,-0.004029179,-0.05519542,-0.016444394,0.0068846545,-0.0013762485,0.0035660495,0.038115658,-0.010699818,0.0791707,0.059070747,-0.014879923,-0.0063606407,0.045820184,-0.01273469,0.03904158,0.021429898,-0.039436806,-0.021584388,0.072509706,-0.12201624,-0.008288759,0.024855185,-0.024570221,0.013952258,-0.05804765,-0.04511021,0.05733519,-0.005377507,-0.026263995,-0.051598538,0.003034693,0.024228048,0.13956614,-0.008863568,-0.005806992,0.029035106,-0.026544657,0.00320478,0.050620396,-0.019904608,0.09673823,0.010235903,-0.031089932,-0.08967246,-0.023426285,0.0065671755,-0.017645007,0.0631372,-0.0010734822,-0.0229221,0.011217851,-0.07828014,1.9327658e-33,0.06847415,0.0031994644,0.007838684,0.00065270654,0.059803113,0.034789886,-0.15064396,0.07472234,0.013641128,-0.035303064,-0.042679805,-0.043087386,0.058009226,-0.04250344,-0.013347044,0.032187812,-0.060831428,-0.017482191,0.004951403,0.00032749568,0.08370144,0.03707986,0.01288984,0.03813564,0.031051612,0.0044791903,0.009543732,0.073752634,-0.0059968927,0.0011507738,0.035211623,-0.16951361,-0.031911664,0.011203258,0.024794795,0.014526418,-0.04084286,-0.09786318,-0.0068091126,0.12296008,-0.043921452,0.052428313,0.067854874,-0.048399996,0.02754062,-0.090208344,-0.055407938,0.1333696,-0.004539227,0.07436977,-0.01824792,-0.01685934,0.1440674,-0.036450706,0.00789291,-0.009548083,-0.02909366,0.025141317,0.06627401,0.04234359,0.06903847,0.055064116,-0.031656113,0.009918797,0.00038994604,0.035376925,-0.11161115,0.0013165349,0.016195456,0.096423715,-0.079794794,0.073083326,0.03318188,0.034768578,0.036621984,-0.042040605,-0.026893983,0.019928407,0.004665729,0.028397705,-0.02286025,-0.0022254342,-0.035841543,0.048547894,-0.06851733,0.03381852,0.0062510567,-0.048591465,-0.02175458,0.052582234,0.042376794,-0.047227178,-0.032728016,-0.00021357957,0.035403844,-2.9108383e-33,0.057939284,-0.04238673,0.0304702,-0.104125775,-0.010400246,0.1259054,0.02372953,-0.023016743,0.032082517,-0.0051246104,0.053343955,0.07819976,-0.03257509,-0.006094707,0.04858181,-0.03761351,-0.0060679927,0.010004529,0.013721904,-0.004226987,0.024250302,0.09986995,-0.033960823,-0.04241503,0.019227827,-0.077274434,0.01231685,0.084453404,0.0064453916,0.057071377,0.09837367,0.05452676,-0.021360708,-0.06309023,-0.030602988,0.06609087,-0.09401326,-0.022658372,-0.0066585545,0.06697155,0.033486247,-0.03607333,-0.0029058119,-0.019546984,0.05343886,0.042807337,-0.10769879,0.012472371,0.03791133,-0.03174312,0.04333029,-0.011440914,-0.033905502,-0.0077594575,0.086332165,-0.013492469,-0.048260164,-0.016951725,-0.017495735,-0.04964771,-0.014275125,-0.046982516,-0.014218439,0.013734801,-0.010542163,-0.022912506,-0.0040702512,0.02631563,0.11737962,0.04531473,0.093111955,0.008049474,0.018204957,0.07904613,-0.0877368,-0.02204043,-0.03075892,0.025954364,0.00020209915,0.0005791428,0.016058695,-0.050486382,0.034428313,-0.117715254,-0.0069305236,0.0016610124,0.01153289,0.09203869,-0.015564867,0.016601406,-0.009981974,-0.029580785,-0.06074451,-0.009110049,0.032553352,-4.2863697e-08,0.07090032,-0.041742403,0.07673509,0.019285904,-0.025251465,0.032599896,0.07375249,0.012114854,0.0024836734,-0.004303424,-0.0154653955,0.07882375,0.053330693,-0.026900219,0.017190397,0.070209146,-0.015196874,0.00798355,-0.012929587,-0.018512785,-0.082820155,-0.067459695,-0.114821166,0.05230325,0.030326128,-0.050491527,0.010737753,-0.0069384715,-0.034618136,-0.066696584,0.03078725,0.0019536763,0.13103059,-0.03427663,-0.043429937,-0.012267215,-0.07495875,0.068171605,-0.04437245,0.05852528,0.08634866,-0.09196205,-0.072115146,0.010874292,0.010980328,0.02465526,0.00545399,-0.006534174,-0.028367212,-0.04597598,0.0509888,0.0061737266,0.011606097,0.026113696,-0.06687893,0.0825195,-0.030947631,-0.089438185,-0.059950504,-0.0671467,0.04316797,0.04602822,0.12267528,-0.050717186 +1.6.5.11,"Menaquinone can act as acceptor. Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives.",384,0.99999994,-0.029463084,-0.04176969,-0.11876462,-0.004798976,-0.07154791,-0.000874984,-0.00085232186,-0.015785271,0.039381877,0.038197666,0.01626278,0.02433999,-0.024635358,0.083967656,-0.0058102757,0.021095837,0.008226189,0.010445388,0.015854053,0.07455797,-0.02048591,-0.012175191,-0.03253368,-0.100193724,-0.040104643,0.007926458,-0.051276375,0.08024704,0.0028854713,-0.04276673,0.010420557,0.028123336,0.060115587,0.027473597,-0.11393455,-0.005880246,-0.08829773,0.0046593132,-0.010003617,0.082137965,0.0010145282,-0.019990327,0.0076912823,0.0039030293,0.032344256,-0.06581086,-0.0673397,0.02712602,0.042351227,0.0717318,-0.04234809,0.026772218,0.038744498,0.08169293,-0.022661407,-0.045174085,-0.07283503,0.023701638,0.026865287,0.005761463,-0.0011711153,-0.04658812,-0.0069646286,-0.0052396096,0.002530663,0.007950689,-0.09822983,-0.067669965,0.011367541,0.059696365,0.09244503,-0.060458012,-0.012029789,-0.0688776,0.04264122,0.066470444,-0.07622732,-0.010574223,0.06471452,-0.030133422,0.018621432,0.03449591,-0.018162427,0.13060525,0.025164194,0.03551512,-0.03558409,-0.0032902625,-0.03496448,0.080208726,-0.009183289,-0.031795193,0.029273817,-0.0627746,0.012865793,-0.05783097,-0.004489301,0.050392285,-0.10740576,-0.020529551,0.020510143,0.013566573,-0.14368558,-0.08049624,-0.089806,0.0426611,0.064846925,-0.014366293,-0.047382746,-0.012218443,-0.10015494,0.022423008,-0.03137015,0.023993215,-0.028220167,0.021860017,0.0964556,-0.073087275,-0.06703768,-0.020173417,-0.039923117,-0.047111668,0.04624049,-0.034914214,0.01888692,0.046265315,0.015198846,1.5134077e-33,-0.03660999,0.02574633,-0.008030182,-0.013571469,0.017892558,0.01105257,-0.03375418,0.0009104114,0.011159122,-0.0951262,-0.037159927,0.03677185,-0.023507653,0.03634628,-0.0032816096,-0.02874333,0.046431188,-0.04207827,0.076693244,-0.070806764,0.08883463,0.077814944,-0.07040633,-0.013262249,-0.052024577,0.03489476,-0.023684915,0.08402192,0.040909488,0.015205136,0.01508901,-0.0055171545,-0.017930498,0.0007662654,0.0037238244,0.03504992,-0.015642043,0.03819133,-0.044412155,0.0034618375,-0.00051920547,-0.004613798,-0.14879021,0.044058926,0.077018276,-0.049531788,-0.05261095,0.0026327476,1.6668964e-05,0.0069879643,-0.015555283,0.0263806,0.00885321,-0.06687069,-0.013325018,-0.014336239,0.0052687274,0.035218917,-0.011053638,0.057431772,-0.008867019,0.014244263,0.0053580236,0.029508876,-0.08283196,-0.015399378,-0.0058974517,-0.098267674,-0.07024871,-0.00013304222,0.022682568,0.008184529,0.048919834,0.05356047,0.04646907,-0.04417113,-0.011221151,0.07853154,0.043821268,-0.046701185,-0.009553396,-0.08015993,-0.030370014,0.10838573,-0.0687252,0.01588573,0.054720808,-0.06775862,0.011691052,-0.04318827,0.030378168,-0.027721379,-0.03877181,0.016356392,0.11787782,-3.6109603e-33,0.07305598,-0.026932776,0.04866805,-0.01084284,-0.008631839,0.118984856,0.020316496,-0.04501943,0.064091444,-0.013899479,0.10531174,-0.019841516,0.031740647,-0.012151334,-0.06928066,-0.038872156,0.022898471,0.027993716,-0.072275065,-0.015703827,-0.029359896,0.03973876,0.090116516,0.034776855,-0.010788799,0.045666784,0.03768641,0.022657318,-0.008605391,0.13633338,-0.003910942,0.034944184,-0.05570819,-0.11456781,0.05559316,-0.012344549,-0.10978736,0.049667105,-0.0570615,-0.009979942,-0.0073568835,0.010367912,-0.012023326,0.06631837,0.08896613,0.042464938,0.010187897,0.039754815,-0.036232345,-0.045019187,0.021125715,0.025293728,-0.054213267,0.03244238,0.11906833,0.053774823,0.08643593,-0.11246583,0.021044292,0.013855498,-0.08871283,0.009250514,-0.020178622,-0.049521763,0.049193893,0.009665607,0.0021125318,0.08906479,0.11147108,-0.028729035,0.087944455,-0.12045252,0.09796843,0.070257016,-0.041649744,0.03502062,0.008360164,-0.056753825,0.029020673,-0.039801195,-0.08563378,-0.008158866,-0.0043541947,-0.023613794,-0.06407942,-0.060549024,-0.0011405121,-0.031557422,-0.07940029,0.124406725,-0.0026134625,0.020555157,-0.035424713,-0.019240025,0.03908362,-3.1046206e-08,0.07326177,-0.019759709,0.0703132,-0.035651717,-0.024195869,-0.04288711,-0.06912421,-0.043289747,0.08071475,0.049171813,0.0022998576,0.06481814,0.050333753,-0.01624803,0.01338837,0.033676285,0.07041861,0.025274908,-0.021236463,-0.031188143,-0.12744503,-0.014715894,-0.014673973,-0.08203547,-0.018460862,-0.037549876,-0.009458688,-0.043684904,-0.0094266385,0.016688518,0.03208025,0.029033938,0.032635067,-0.035387266,-0.00943186,0.07868596,0.030414745,0.011399763,0.018602202,-0.039304473,-0.017760376,-0.041756768,-0.0031541479,0.029096544,-0.061930675,0.023722174,0.04752075,0.025635505,-0.05454623,0.00962002,-0.013956339,0.002991985,0.07203214,-0.085311644,-0.08859757,0.047372956,-0.042463113,-0.035662293,0.020481747,-0.112568416,-0.037889052,-0.00023969538,0.05742228,0.041289236 +1.10.5.1,"A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3].",384,1.0,-0.053198025,0.034514032,-0.06917472,-0.037711557,0.06674449,-0.011764428,-0.05092604,0.02375404,0.029101806,0.008134588,-0.06036129,0.028470002,-0.09234694,-0.0029736587,-0.05685167,0.09042059,-0.011560803,0.017986992,0.020126143,0.02468567,-0.06473982,-0.05134789,0.002281836,-0.0129602365,0.03387469,0.012494654,0.0034291875,0.034129158,-0.12281977,-0.04021179,0.038315848,0.013199684,-0.0109166615,-0.012439054,-0.088271216,0.07647805,-0.077395916,-0.010055295,-0.024692506,0.052964855,-0.002154282,-0.0139643485,-0.050762936,-0.04448899,0.02309972,-0.09366863,-0.072414264,0.07991228,0.012591311,0.024314327,-0.061995897,0.010919458,-0.05079241,0.08869037,0.061183464,-0.053102113,-0.06664423,0.06633207,-0.029128203,0.029524963,0.020862585,-0.03946874,-0.04902088,0.007513292,-0.03227318,-0.022450687,0.015031276,-0.051733274,0.013399348,-0.03147235,-0.031267416,-0.009842701,-0.012847203,-0.0030613183,0.00018605098,0.07351894,-0.03649757,0.030750114,0.08321689,-0.030443236,0.040564723,-0.02741426,-0.009530677,0.06392545,0.099872194,0.040333424,-0.06151723,-0.012335851,0.007992102,0.03155036,0.0363031,0.015712334,0.057504006,-0.019809235,-0.052516133,0.08459731,0.01745623,-0.009770554,-0.08146,-0.008484694,-0.010256664,0.05343028,-0.04431992,-0.070587054,-0.14953221,0.013982333,0.05609943,0.07313876,-0.055958077,-0.016486673,-0.045953956,-0.02377268,-0.013254407,-0.011050873,-0.029317152,0.09653359,0.050507657,-0.08679747,-0.047959413,-0.009546936,-0.03357859,0.008969075,0.08606854,0.024351567,0.06525566,0.0205289,-0.07775796,5.8173375e-33,0.09660511,0.06379623,-0.00742767,0.009495338,0.03840677,0.05347307,-0.080753274,0.052911814,-0.03222096,-0.06831163,-0.0013561278,-0.044320118,0.0677711,-0.056280065,0.04755318,-0.007069885,0.03550122,-0.0021957431,0.048263066,-0.03241447,0.09675592,0.03008903,-0.068981946,0.016788054,0.0077275946,0.024885384,-0.050339665,0.07890719,0.026723878,0.024451768,-0.038307656,-0.09085537,-0.038159586,0.059997376,-0.016870031,-0.002756243,-0.14680204,-0.023869358,-0.018103728,0.057482727,-0.07213437,0.016428316,-0.044745598,-0.0472458,0.026919503,-0.035221353,0.0018326534,0.055647545,-0.038766176,0.08827453,0.014297023,0.011262877,0.09166465,0.010559273,-0.06187613,0.065759264,0.0023210784,0.01556074,0.0335097,0.06196214,-0.010475909,0.07146385,-0.02925925,0.03484962,-0.042809457,-0.033445735,-0.037713826,-0.09066626,-0.009861268,0.08735205,0.0037290626,0.0076428265,0.13629682,-0.0006236127,0.07358708,-0.022303661,-0.012584301,-0.036673784,0.040269256,0.01547796,0.02967022,-0.061181545,0.016208503,0.025106663,-0.03551586,0.004818428,-0.006989548,-0.03536074,0.021745984,-0.01917765,0.020709038,-0.07876022,-0.012366318,-0.081942774,0.07651515,-4.5180735e-33,0.069986075,-0.016256886,0.033411022,-0.0015743205,0.025048388,0.106576756,0.08760638,-0.11350386,0.07227381,-0.0787751,0.11813227,-0.035179093,-0.0027157506,-0.038379077,0.015353914,-0.009138889,-0.056843486,0.0051640077,-0.0068012956,-0.011281847,-0.02615459,0.048757013,0.018084379,0.032744326,0.013803664,-0.012288784,0.026207441,-0.012640405,0.06831724,0.038838916,-0.092589214,0.05530829,-0.034082793,-0.031766675,0.026763242,0.0415952,-0.107049435,0.033573672,-0.030906895,0.048538197,-0.0022740648,-0.039576463,-0.010654374,0.019218294,0.037026267,0.04826454,-0.09807846,0.08346856,0.08127817,-0.005001696,0.024668865,0.05470798,-0.039855156,0.08672953,0.100965306,0.017154573,0.08881434,-0.01909843,0.0376213,0.022748899,-0.07892767,-0.077108815,0.048338998,0.04739143,0.056954786,0.03848316,-0.01702809,0.13458729,0.014497851,-0.023851633,0.07713052,-0.046246216,0.07145853,0.0685483,-0.037463285,-0.05444894,0.042604,-0.00862776,-0.052380096,-0.010856606,0.054207735,-0.035258617,-0.023117883,-0.08361011,-0.034316644,-0.038805336,-0.034572147,0.003861374,-0.05395286,0.049455274,0.0067621176,0.02901273,0.023753999,0.06473622,0.021219593,-4.7996515e-08,0.027565256,-0.061342355,0.026552383,-0.012259594,0.03229476,-0.027687188,0.008924671,0.03300449,0.014962893,0.0005404463,0.010780002,0.11549953,0.006798293,0.01972759,0.057622153,-0.03181247,-0.005057536,0.019526163,-0.034905702,-0.026353415,-0.007511341,-0.022849508,-0.16189332,-0.03251123,0.010842152,-0.053121846,-0.014957136,-0.06582258,0.038966537,-0.02707647,-0.00088701723,0.009334731,0.09455168,-0.0067354743,-0.060622055,0.006498981,-0.04075196,0.03906281,-0.08589134,0.0053720362,0.003035463,-0.014737164,-0.032676313,0.014013619,0.0036187486,-0.032678,0.038811248,-0.014705297,0.022538958,0.032273132,0.015314333,0.06874403,0.0447312,-0.103011616,-0.049187858,0.070599794,-0.004564973,-0.08322284,-0.012553654,-0.1077709,0.04189265,-0.07445958,0.12749235,0.04765236 +1.13.11.80,"The enzyme, characterized from bacteria Streptomyces toyocaensis and Amycolatopsis orientalis, is involved in the biosynthesis of (3,5-dihydroxyphenyl)glycine, a component of the glycopeptide antibiotic vancomycin. 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",384,0.99999994,-0.025490774,0.018102044,-0.12498748,-0.04706609,-0.019461151,0.051816385,-0.062301375,0.03163911,0.12190303,-0.06612645,0.0026100138,-0.032466467,0.029126395,-0.02357339,-0.083088286,0.025526587,-0.020343062,-0.004543464,0.032093067,-0.027282268,0.09591196,0.06375302,-0.006619954,-0.0378705,0.062004037,-0.028879296,0.016327506,-0.05624845,-0.05812831,-0.08570579,0.08448616,-0.003452405,0.004098746,-0.04508941,0.11721253,0.0943793,-0.06963982,-0.037724398,0.10439481,0.043330643,0.021482408,-0.032138407,-0.009335362,-0.0147883175,-0.072777264,0.0562355,-0.003152775,0.0072463052,0.008360103,-0.03445412,-0.07214168,-0.059965197,-0.02581765,4.6865895e-05,0.11430481,0.03578573,-0.007819034,-0.031619776,-0.06709168,-0.050893124,0.0899496,0.0007880851,0.06068578,-0.00739096,-0.08557368,-0.0054685012,0.021066504,-0.0835872,0.06293966,-0.05518836,-0.11199969,0.019490028,-0.05000204,-0.0010584699,0.004803575,-0.044406448,-0.067553736,0.032643072,-0.013521247,-0.003907596,0.04090418,-0.00045724667,0.01063462,0.069331884,0.045425296,0.011763567,0.057202127,0.05625494,0.08421389,0.030616974,-0.022978395,-0.03289081,-0.021237146,-0.044635557,-0.03605663,-0.033434287,-0.06167352,0.00027575155,0.023020666,-0.008796678,0.0034793678,-0.010409831,0.015325842,-0.052965548,-0.05706158,0.016249934,0.016641838,0.021805786,0.07831633,-0.03909914,-0.024288194,0.016034955,0.023460945,-0.029265374,-0.040193338,0.06904189,0.09580589,-0.07291081,-0.053045303,0.011179965,0.015843159,-0.031144818,-0.0003001772,0.061660647,-0.043288436,0.054083064,-0.13548584,5.2850327e-34,0.015705004,0.060506035,0.058467675,-0.0645202,0.042465556,-0.013045069,-0.05638521,-0.06725043,-0.009753456,-0.099435836,-0.07289053,-0.10716257,-0.053506505,0.035201214,0.044882514,-0.012392408,0.0019200527,0.05472481,0.044639602,-0.0039261533,0.0044964296,0.05141832,-0.07930918,0.018743422,0.012358649,0.05722659,0.025819913,-0.0063605965,0.06049436,-0.03850338,-0.0011584329,-0.07197165,-0.04678164,0.03129278,0.09230141,-0.0069814166,-0.049901124,-0.007983993,0.02880586,0.032688342,-0.04989014,-0.0075526247,0.0058210744,-0.010955207,0.02527523,-0.018492332,-0.04969812,0.08200893,0.06876616,0.06863206,0.019266183,-0.0038575951,0.118414916,0.040504057,-0.065607026,0.017966151,-0.05067334,0.030253606,-0.028130842,0.0005271742,-0.016503967,-0.026262326,-0.007684599,-0.022775287,0.059925973,0.014678274,0.013782874,0.024299402,0.03964286,0.017598609,-0.075436406,-0.02043043,-0.0028654728,0.04856615,0.00853615,-0.0011036065,-0.1103877,-0.040200688,0.07034154,0.031161869,0.008886295,-0.0058065658,-0.008801184,-0.13102025,-0.08515638,0.021622026,-0.013389887,-0.044668596,0.019361943,0.081027575,0.003597012,-0.11553972,-0.061071537,0.069198005,-0.0041786893,-2.6881319e-33,0.08103109,-0.086514816,0.07371177,-0.009750976,-0.012531634,0.07142699,-0.011785355,0.01097135,-0.0046440875,0.007836803,0.064695746,-0.040429436,-0.01991982,-0.045705672,0.038182206,-0.009408098,0.038113568,0.1376307,-0.010329985,0.04394507,0.008350212,0.06660459,-0.054993723,-0.0003261417,0.018611826,0.0898182,-0.0019084691,0.09699109,-0.011466591,0.042667683,0.016036587,-0.018627893,-0.039948855,-0.041691627,-0.02000449,0.06279571,-0.052970212,0.05411864,0.08922253,-0.0013738595,0.054657374,0.007014057,0.066105105,0.07980667,0.022558404,0.019418146,-0.10761166,0.031468797,0.023458954,-0.10454192,-0.03632947,0.064987555,0.04737771,0.0044301446,-0.009795359,0.04574525,0.014215158,0.008578726,-0.03907028,-0.052109875,-0.07063898,-0.04726851,0.031361654,0.045276262,-0.0023523744,0.023983806,-0.018613739,-0.0076215733,0.06305798,-0.023570603,-0.014245104,0.021126654,-0.040673837,0.07869666,-0.004092474,-0.037102718,-0.11285821,-0.02599915,-0.012180789,-0.025658397,-0.018588489,-0.04828339,0.0089004375,-0.13224453,-0.00228237,-0.052754525,0.101513304,0.009264713,0.03688899,0.01863691,-0.014278048,0.054519612,-0.0715728,0.0628999,0.02068566,-2.8124218e-08,0.058981553,-0.082797654,0.03471472,-0.02893203,-0.01406391,-0.045385025,-0.0021056652,-0.02900522,-0.030057833,-0.026095508,-0.015403038,0.032131333,-0.025020825,-0.013704851,0.03392951,0.0063166833,-0.04225488,-0.023531735,0.0188513,-0.056277636,-0.07495468,-0.012005879,-0.09947092,0.03825594,0.04638063,-0.035170183,0.05200555,0.05377051,0.03789163,0.008676265,0.022537585,0.038355466,-0.040439084,-0.0056526973,-0.0959219,0.024408128,-0.04058918,-0.038861796,0.0837496,0.0049358797,0.027231645,0.023688156,-0.065104015,0.007911874,-0.02781739,0.047751747,-0.02026217,-0.03205913,-0.068664886,0.017400173,0.045254346,0.02380812,-0.03582958,0.036098585,-0.117126,0.050596513,0.016429026,0.01740495,-0.05940811,-0.047815073,-0.04047968,-0.03549,0.20043898,-0.058465432 +1.14.11.48,"Requires Fe2+ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine.",384,1.0,0.02513193,-0.107790075,-0.06733192,0.012008965,0.06734093,0.019122139,-0.015909737,0.07003945,-0.04971622,-0.030224416,0.06479361,-0.041243114,-0.04825168,0.032884818,-0.03883185,0.04147076,0.022035664,-0.052617956,0.02011621,0.019223796,0.120509736,0.010941886,0.046805892,-0.030858433,0.0035928693,0.010377821,-0.022766832,-0.0405625,0.029914478,-0.07549022,-0.049848318,0.02358029,0.06317541,-0.04806984,-0.0092538055,0.08574677,-0.03986733,-0.037208006,0.030272197,0.015101708,0.027612666,-0.07620648,-0.02180354,0.008187062,-0.042989086,-0.058534816,0.039697137,-0.002376524,-0.0028963855,0.08499148,-0.041561406,-0.03426061,-0.01092799,0.018808478,-0.0139130205,-0.023636,-0.04906039,-0.012235754,-0.054118823,0.05145817,0.007437393,0.084088005,0.0096359085,0.0048745647,0.031743076,-0.05066227,-0.03177874,-0.048453946,-0.008890532,0.024176275,-0.016364705,-0.036215644,-0.0054243,0.031842202,-0.006297892,0.03690914,0.056150507,-0.059847414,0.036314126,-0.016162068,-0.041816875,0.06991846,0.014891278,0.066335246,0.013452805,0.021572834,-0.028386058,0.038434677,-0.06277172,0.11314702,0.071933016,0.05243671,-0.06937131,0.0015492043,0.036331356,-0.008180679,0.12903598,0.005280555,0.019598523,-0.04333739,-0.011172978,0.037681427,-0.016466906,-0.00348551,-0.04491926,-0.065978,-0.05387054,0.018367385,-0.008298065,-0.01678101,-0.025847953,-0.039810248,0.03859313,0.003262263,-0.00043379512,0.07122125,0.036496457,-0.03264802,-0.0805862,-0.012993305,0.048016317,-0.03835191,-0.05493938,0.08697315,-0.0112008145,0.005734411,-0.08410613,-2.4372235e-33,0.051065188,0.114279635,-0.01992039,-0.043684043,-0.043796636,0.041941825,-0.020875923,0.045277003,-0.013621185,0.014787062,-0.02667086,-0.0787227,-0.01869454,-0.0042128926,-0.035556797,-0.034770474,0.012971656,-0.03394886,0.042354178,0.005920391,0.08601168,0.024834877,-0.054137506,0.029658647,-0.07414788,0.08633729,0.018358473,0.023765441,-0.01115962,-0.0324952,0.028029008,-0.06359679,-0.043687213,0.096392445,0.048721258,0.015533529,-0.01731835,-0.063851394,-0.005763462,0.0012577013,0.013947389,0.0837265,0.023196448,-0.06047589,0.0815028,-0.072787695,-0.11813969,0.021299759,0.07790154,0.019951673,0.045090713,0.04097366,0.09191513,0.052916918,0.012510106,0.018232262,-0.10734599,0.030627271,-0.04967545,0.022556363,0.0023642855,0.0045876796,0.0068638646,0.067483805,-0.012402347,0.02319394,-0.09266022,-0.04103342,-0.027951732,0.061326474,-0.08802163,-0.054888234,0.04879021,-0.040004224,0.05307489,-0.019143876,-0.1178148,0.035209652,0.040400323,-0.038684785,0.042117424,-0.047135353,-0.0079661915,-0.0034936415,-0.08910692,-0.0050480124,-0.004941809,0.04592251,0.033332113,0.023732316,0.035563666,-0.09560797,-0.061271667,0.019506766,-0.0022251282,1.7271788e-34,0.020599427,-0.028170314,0.096079245,0.04340161,-0.041904073,0.095279545,-0.010469848,-0.10591183,-0.020551706,0.00456895,0.027586596,0.04409633,-0.0053850785,-0.06873722,-0.016260743,0.093209155,0.018481966,0.076183714,-0.004432362,-0.023912553,-0.054181278,0.12630488,-0.043168668,0.0071597775,0.09038427,0.018765703,-0.009705908,-0.005043166,0.061997693,0.023563474,-0.011743652,0.031748302,-0.018468479,-0.11220188,-0.012527389,-0.036245946,-0.040928878,0.030660514,-0.020622289,0.045707326,0.0190838,0.006364647,0.044923615,0.11563345,0.020443974,0.07038882,-0.03490342,-0.05629186,0.070414364,0.078789026,0.027126422,-0.022250356,-0.07457129,-0.025477178,-0.009578233,0.030877879,0.009374714,0.025986755,-0.041671973,0.0046696025,-0.046353217,-0.057649616,0.014945082,-0.09635177,0.028533569,-0.018951561,0.015399575,0.1134625,0.08408196,-0.0071629835,0.1185065,0.05007668,0.031238124,0.017215423,-0.0482065,0.009894701,-0.023193909,-0.051102925,5.6646327e-06,-0.050311133,0.018751208,0.05217154,0.060941175,-0.046225112,0.007259578,-0.052791066,0.04450675,0.08855417,-0.048652343,-0.031384367,0.008639478,-0.04696505,-0.012901279,-0.017842172,0.13033256,-2.5227903e-08,-0.04788082,-0.05117209,0.00678887,-0.06842634,-0.013921845,0.0093834,0.043456346,-0.01404319,0.026334925,0.0021206776,-0.04162166,0.061525248,0.0652832,0.003965985,0.06306107,-0.103059426,0.054042663,0.087135114,-0.06605511,-0.033917315,-0.10517189,-0.053008575,-0.13474083,0.004028796,-0.022488564,-0.112490445,0.019530531,0.03367089,0.058500484,-0.0032621871,-0.05011686,0.03992508,0.023498647,-0.06742803,-0.09064625,0.07252363,-0.05204512,-0.09431485,-0.0019084585,-0.0417202,-0.018200869,-0.020825412,-0.021386852,0.007957515,0.005601125,-0.029930186,0.010621743,-0.047825564,-0.0014791648,0.0069077113,0.046067476,-0.0021998344,0.030041216,-0.11980751,-0.035702463,0.09502436,0.0018738515,0.009434114,0.03004606,-0.08613666,-0.010265507,-0.022875752,0.14070727,-0.11230749 +1.14.13.201,"The enzyme, found in plants, is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can also convert alpha-amyrin and lupeol to ursolic acid and betulinic acid, respectively. The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not catalyse the reaction to completion, resulting in accumulation of both intermediates.",384,1.0,-0.056584325,-0.017323205,-0.15047105,0.0047366377,0.03131536,-0.005128448,-0.08249559,0.047961585,0.063189335,-0.0026116373,0.019535813,0.07114923,-0.09079587,-0.053731788,-0.06890492,0.015453928,-0.090804085,0.04602515,0.012465269,0.025360173,0.09160172,0.0048435223,-0.0126765,0.019615753,0.044682235,-0.054846726,0.02112461,-0.004890483,-0.04502942,-0.0005222042,0.02806112,0.012051806,-0.02366156,-0.07390291,-0.028776966,0.029281324,-0.12820491,-0.08340564,0.06842515,-0.014261482,0.08429414,0.0009500166,-0.020505771,-0.029061945,0.015220619,-0.085302524,-0.06741552,0.031376217,0.048880626,-0.020913208,-0.07940818,-0.04817469,-0.015451783,0.0098386,-0.024067426,-0.024206527,0.00053019455,-0.07012262,0.00361035,0.11357794,0.014067087,0.06464766,-0.026848264,-0.02372642,-0.04351188,-0.053888176,-0.07367425,-0.02251824,-0.007986127,-0.062009044,-0.08539016,-0.08904459,0.0015289754,0.03765398,0.006142847,0.029332973,-0.010468922,0.06350632,0.010713451,-0.02625145,0.041478015,-0.052491892,0.009799084,0.1204628,0.018340718,-0.01259697,0.053141266,0.026438614,0.06732825,0.034080878,0.088004224,0.051954705,-0.032458175,-0.0056548985,0.02752951,0.020575525,0.021400468,-0.02950481,-0.026322579,-0.014512212,-0.012977191,0.031743877,-0.012266649,-0.20405993,-0.05277943,0.07800085,-0.015997123,0.0040466003,0.047544904,-0.018530913,0.008933374,-0.03381485,0.017544111,-0.00043898256,-0.04397256,0.06345444,-0.038364746,-0.12942669,-0.030320432,-0.042189058,0.005669188,-0.043130964,0.090615734,0.028770072,0.007680501,0.010681468,-0.058865063,2.653916e-33,0.080454595,0.0024563293,-0.019397596,-0.05554125,-0.011891058,0.037716303,-0.017126068,-0.036204387,-0.028391216,-0.099278696,-0.17345855,-0.03409255,-0.03340006,-0.033442274,-0.012438165,0.020954736,0.01730702,0.0133121135,0.07122097,0.03763431,0.030922236,0.037134107,-0.09712137,-0.026467862,0.0082044285,0.10089382,-0.052878316,-0.013665509,0.038731545,-0.009450612,-0.0010404956,-0.040003385,-0.05083204,0.024461513,0.10272514,0.04377386,-0.026575878,-0.064504355,-0.06557381,0.029528456,0.028918048,0.03191758,0.07765399,0.05040968,0.05628144,0.022176087,-0.064375386,0.059494577,0.066972494,0.08148454,-0.014650571,0.020936042,0.062874325,0.027434424,-0.07434724,-0.009219141,-0.036019947,0.021953944,0.056773007,0.0055943164,-0.036539994,0.01628404,-0.015526186,-0.0015413382,-0.044865623,0.09579878,-0.09216887,-0.03654673,-0.019099819,0.061915815,-0.039408688,-0.059770167,0.043976657,0.0033019993,0.016146762,-0.014963279,0.014061548,0.013730554,-0.020064292,0.034349702,-0.0009664026,-0.0417952,-0.037301376,0.016520645,-0.024186203,-0.01683696,-0.033805486,0.013039481,-0.014959048,0.0060461313,0.058061022,-0.0013159845,-0.06313963,0.075962454,0.0026273106,-4.7998704e-33,0.106526725,-0.12147311,0.06308771,-0.04490875,-0.007498637,0.05881521,-0.03507548,-0.11841993,0.037422355,0.02094746,0.069405615,-0.0689131,0.05706213,-0.028732376,-0.012431882,0.018860739,0.05642472,0.08296883,-0.06358799,0.0029727991,-0.027492872,0.12098095,0.051070202,0.04057011,0.009915352,-0.053188466,0.05996668,-0.0018614961,-0.042583227,0.01112159,0.04151006,-0.015115514,-0.06726497,-0.011299733,-0.0486431,0.08426328,0.01599749,-0.04558734,0.0367004,0.04156848,0.02155463,-0.035539918,0.01984072,0.080825895,0.08688348,-0.034208994,-0.100206666,0.008120898,-0.05053057,-0.009209689,0.13893612,0.026215222,0.05398607,0.02669053,0.058357675,-0.005098357,0.0333836,-0.017868191,-0.0592333,-0.015965287,0.025314147,-0.057039257,-0.008690254,-0.017650578,0.010982267,-0.006461942,-0.042263724,0.037882682,-0.00012422529,0.003520962,0.08383424,0.0457024,0.03850926,0.10927247,0.030778171,0.030892419,-0.033336688,-0.10065556,-0.023144295,-0.046084784,-0.012883318,0.019500848,0.05022481,-0.06418492,-0.11966324,-0.068268664,0.011249423,0.053438645,-0.009806724,0.04185917,-0.020055799,0.009428489,-0.036961522,0.0398398,0.036323875,-4.123021e-08,0.0056144875,0.011860127,0.0070236023,-0.003961652,-0.038406655,-0.033746853,-0.0016638979,0.015427218,0.01571056,-0.04071414,-0.0072226925,0.10901828,-0.0028878895,0.006308511,0.09345223,-0.015869604,0.036501117,0.050494213,-0.001343959,0.049050126,-0.017002758,-0.030040348,-0.07589556,-0.0015485636,0.01202071,-0.10988874,-0.023525117,0.03949312,0.001933594,-0.007234668,0.032628328,-0.018238429,-0.0035070833,-0.030608872,-0.051985722,0.06892074,0.012610154,-0.063754365,-0.024028739,0.036962163,0.0017286837,-0.05043768,-0.04509194,-0.04391849,-0.051749002,0.00033482883,0.0835756,0.004397245,0.05098889,-0.007432126,0.029633082,-0.003918942,0.009860933,-0.06542177,0.0129107395,-0.06597042,0.025859,0.009072773,0.0334069,-0.050000876,-0.016225575,0.01958636,0.18348816,0.041507553 +1.14.13.202,"A heme-thiolate protein (cytochrome P-450). The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.13.203, farnesoate epoxidase) [1,2]. ",384,1.0,-0.021049658,0.03130591,-0.04136808,-0.02395036,0.08239378,0.10969798,-0.01907119,0.056859273,0.008231939,-0.0141905155,0.029280175,-0.07262374,-0.087219365,0.0472202,-0.018744279,0.07632623,-0.03664964,0.013184581,-0.008554224,-0.05994189,0.03276531,0.06055109,0.035297584,0.016225567,-0.028479386,0.016589027,0.010314686,-0.013057506,0.010496162,-0.08573084,-0.045659456,0.0031599575,0.050796498,0.020339228,0.038738817,0.09820265,-0.047035664,-0.07749761,0.025286958,-0.025171382,0.08473764,0.030687293,-0.070670485,0.031429753,-0.06371438,-0.016216015,0.028291995,0.023051439,0.020613432,-0.00021435157,0.0031080516,-0.10697225,-0.05598279,0.04964429,-0.026528986,-0.017910872,0.024912927,-0.03300383,-0.019593267,-0.012266966,0.04208897,0.058570813,0.014255304,-0.012213761,-0.0034759333,-0.057515893,-0.014155598,-0.046844777,0.024266023,-0.1340069,-0.043104082,-0.08064857,-0.07669504,0.08518218,-0.057037726,0.036584225,-0.023176141,0.004106926,0.020162668,-0.014085874,-0.035669625,-0.027095523,0.030368198,0.10019996,0.09899035,-0.022106057,-0.036319267,0.08225054,-0.02692286,-0.014191306,0.018345984,-0.038638458,-0.0341768,-0.030217346,-0.04950046,0.018563563,0.030672079,-0.013135877,0.012476237,-0.007835417,0.06307986,0.019915815,-0.016380962,-0.056955,-0.05846305,-0.01004052,0.014080312,0.030221084,0.07548077,-0.07842438,-0.06520912,0.007721049,0.10002291,0.018504595,-0.01802985,-0.03311123,-0.046037994,-0.057490896,0.034623038,0.009725289,-0.035931833,0.024362464,0.049808837,0.032494422,0.019841108,-0.018655222,-0.1763611,3.9439893e-34,0.085121185,0.057062533,0.020781627,-0.027441673,-0.06604748,-0.019839834,-0.035551194,0.10158019,-0.013032927,0.008767162,-0.07306533,-0.060549397,0.047488794,-0.024194105,0.0027758009,0.031156367,-0.029539019,0.009801848,0.10588279,-0.05150851,-0.07700075,-0.0025194308,-0.025969926,-0.06083526,0.06977845,0.10771686,-0.02492995,-0.02836274,0.049953792,0.020385263,0.033264987,-0.08787181,-0.021547304,0.016499648,0.03711998,0.0051457337,-0.03267668,-0.039991885,-0.09810617,0.03697002,-0.0018633043,-0.048141975,-8.7385604e-05,-0.07886559,0.056510635,-0.09428926,-0.16293755,0.051863614,0.04725551,0.01789993,0.053198744,-0.022233838,0.07847052,0.016320786,-0.09536198,0.016118737,0.015129075,0.02497054,-0.017320868,0.0070341807,0.06400494,0.061261017,-0.04351252,-0.0005877212,0.06475264,0.026442075,-0.03963608,-0.014010414,-0.05593526,0.09693314,-0.00032110966,-0.043238327,0.047014907,-0.041907568,0.010092977,-0.036834028,-0.04929878,0.020095864,0.056317527,0.019662805,0.03167871,-0.031244233,0.0037203687,-0.037017528,-0.053637166,-0.039426766,0.06909371,-0.014748091,-0.0145998495,0.09343749,0.022398984,-0.109770454,-0.009306152,0.014550141,-0.0122388555,-6.844254e-34,0.021117106,-0.048972018,0.026109738,-0.08685501,0.042523142,0.05122688,0.019807259,0.006927547,-0.027660562,0.00089586276,0.11548682,-0.0068062907,-0.015703876,-0.051675618,0.032824162,0.040812947,-0.01968231,0.0069178618,0.06919533,0.0266936,-0.047096357,-0.016445117,0.0073255706,0.055920392,0.021231228,0.02587369,0.054496597,0.024656836,0.049578883,-0.0041981423,-0.04478034,0.042237647,-0.007186986,-0.0640021,-0.045416735,0.014383916,-0.02702336,-0.027898405,0.032241948,0.025332812,-0.035059236,0.047365125,0.024365153,0.059382856,0.046229184,0.13030346,-0.084952064,-0.059539706,0.021042632,-0.009067145,0.04453318,0.030459942,-0.0073481654,0.025992183,-0.034899928,0.027414914,-0.07023967,0.03223211,-0.010014236,-0.083317794,-0.04911692,-0.030262237,0.008515922,0.10611607,0.0016577553,0.06626911,-0.10833066,0.081887834,-0.02907358,-0.008265815,0.062204286,0.007927048,0.048878003,0.09054703,-0.058102697,-0.019597733,0.06498983,0.015020642,0.06967382,0.007125446,0.007848465,0.045355387,-0.05179429,-0.04569101,0.003433942,-0.07446986,-0.054845735,0.10543447,0.0056698923,-0.033850808,-0.03393132,0.030751185,-0.042817935,0.042826988,0.0953614,-3.509726e-08,0.01605394,-0.1419109,0.0042314115,-0.0545686,0.032795884,0.02240936,0.04384024,-0.00481301,-0.0016841152,0.0027579046,0.048060544,0.03486454,0.010825124,0.00040071766,0.05583248,-0.020765347,0.0012965101,0.02082178,0.020678934,-0.0044229273,-0.033381376,0.09062401,-0.03454604,-0.0030749459,0.03258421,-0.059359696,-0.029403377,-0.015746824,-0.021773815,0.019764794,0.016196182,0.085672,0.007964428,-0.0024703646,-0.043825496,0.042896368,-0.0036997509,-0.047636215,-0.051836222,-0.0034998711,0.015017349,0.009172561,-0.06663341,-0.055945244,0.049859084,-0.035993423,0.110114016,0.06887405,-0.0057959235,-0.05176611,-0.015138789,0.016873265,-0.034612343,-0.094218,-0.11489767,-0.007908278,0.031506877,-0.09245098,-0.06283336,-0.087756544,0.07571181,-0.026522359,0.19230247,-0.005041038 +1.14.13.203,"A heme-thiolate protein (cytochrome P-450). The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.13.202, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.",384,1.0,-0.0362831,0.042271193,-0.047162186,-0.00803428,0.07576646,0.099547155,-0.036698844,0.053537913,-0.0028334572,-0.01771355,0.018564548,-0.06663662,-0.10422984,0.042301945,-0.030262677,0.06715141,-0.049992364,0.022173446,0.0009524754,-0.07313429,0.020565005,0.03733204,0.041558597,0.03373867,-0.020555353,0.0028524802,0.008272691,-0.006184936,-0.016964385,-0.08499836,-0.025534179,0.00031499003,0.05657286,0.010706948,0.021808226,0.09076127,-0.032693636,-0.087509796,0.032551132,-0.009711104,0.08819301,0.012019197,-0.08373235,0.040974528,-0.06729358,-0.008477528,0.0045729843,0.033581585,0.011258893,0.016900843,-0.00078601146,-0.12836449,-0.04038058,0.06334578,-0.019548332,-0.0054251966,0.0246804,-0.013943611,-0.00966397,-0.014679948,0.024847146,0.062927425,0.0012725755,-0.00013059055,0.0047361036,-0.06565006,-0.009156548,-0.028571133,0.030188559,-0.13311443,-0.0021234413,-0.083593324,-0.045755245,0.080003545,-0.04349244,0.01782549,-0.040738136,-0.0039531225,0.0297039,-0.021594392,-0.021774758,-0.0279524,0.03719051,0.10989007,0.07909124,-0.04576098,-0.03000371,0.060765926,-0.04061213,-0.0115189385,0.023732053,-0.045448903,-0.03723271,-0.024370406,-0.045982804,0.031471837,0.010021194,-0.029182855,-0.0035666155,-0.023688676,0.06472946,0.015160406,-0.0043424615,-0.051027667,-0.07365915,-0.016025461,0.009831312,0.026974604,0.05479578,-0.06748817,-0.059284274,-0.00559838,0.10763775,0.028212743,-0.027987225,-0.015968388,-0.057421822,-0.048135154,0.019748649,0.0046491968,-0.034700792,0.04141789,0.048500646,0.052692328,0.00468516,-0.016609164,-0.17181455,-6.0756573e-34,0.0877724,0.055230148,-0.002205519,-0.017182002,-0.06295423,-0.011966399,-0.02663174,0.092105925,-0.03800315,0.003665874,-0.067585975,-0.062321965,0.033212513,-0.04295871,0.020516869,0.010438982,-0.023986084,0.028684355,0.1057665,-0.019896166,-0.05476548,0.003938315,-0.022211604,-0.06349054,0.06674689,0.11416374,-0.026974188,-0.01813625,0.03278247,0.020635197,0.047143776,-0.09614615,-0.012600243,0.016503638,0.025120078,-0.01851688,-0.02708335,-0.048387174,-0.09849577,0.04863029,-0.0055949874,-0.059365157,0.0086229695,-0.07714441,0.048439465,-0.09135125,-0.15219049,0.05227741,0.056506775,0.043253545,0.065869235,-0.042294916,0.07682182,0.008674864,-0.083680436,0.04528117,-0.004459659,0.0046044495,0.016921801,-0.008554406,0.07711747,0.068037614,-0.035012085,-0.021310952,0.05992315,0.018280532,-0.035474,-0.0033096524,-0.06331535,0.11937022,-0.0029749689,-0.061734166,0.024271555,-0.046988744,0.024232956,-0.026616458,-0.031325184,0.045574956,0.037814427,0.0017575964,0.062175833,-0.043725368,-0.014748082,-0.019875813,-0.044022117,-0.046741188,0.0565792,0.0053902096,-0.013584453,0.12244054,0.026825367,-0.12577984,-0.010930791,0.014266568,-0.0064798696,4.2522985e-34,0.044695653,-0.06640322,0.0287198,-0.087409474,0.044958826,0.063695714,0.02525643,0.018232122,-0.002506239,0.026278047,0.11598316,-0.0042212415,-0.017131077,-0.06541125,0.030462915,0.041546073,-0.016586307,0.013634407,0.06804284,0.011088213,-0.058112856,0.005850425,-0.011468673,0.0597733,0.024602778,0.020986311,0.055085678,0.019357456,0.04691069,0.012559272,-0.039484505,0.020914113,-0.002924453,-0.04800949,-0.04968512,0.016568758,-0.028873965,-0.0018302922,0.028668394,0.0030595649,-0.02887063,0.044314604,0.026641844,0.06211842,0.038885564,0.118295185,-0.08270874,-0.0348738,0.020378703,0.006584257,0.03501748,0.025772821,-0.0010485275,0.027259167,-0.06659428,0.014973599,-0.0627777,0.02205205,-0.013501856,-0.08633793,-0.039750192,-0.039883237,0.0064433957,0.09274107,0.012351636,0.05920124,-0.13057238,0.065958604,-0.025141584,0.013088753,0.08024998,0.018573018,0.053314205,0.0946391,-0.049862657,-0.03696643,0.047911454,0.011577939,0.075680144,0.011493834,0.016214402,0.034614906,-0.040904753,-0.04909457,0.012651317,-0.08293816,-0.039562885,0.10905815,0.01176001,-0.0379495,-0.03901074,0.036086086,-0.049652968,0.029521683,0.10777081,-3.5075605e-08,0.010579641,-0.13223079,-0.0017793524,-0.02881268,0.030190043,-0.006837621,0.0392849,-0.007471783,-0.0065011955,-0.0069460887,0.01819383,0.054982543,0.02649028,-0.015422571,0.06668031,-0.027240327,0.012796099,0.034055647,0.024076998,-0.0008466996,0.00024970292,0.08089762,-0.039594553,-0.006586299,0.02322565,-0.062359005,-0.007759787,-0.012967509,-0.03278319,-0.0028387127,0.042878382,0.07592231,0.01210186,0.0031355387,-0.031783395,0.04034817,-0.018599954,-0.04871502,-0.046421323,-0.029735904,0.007667624,0.008105128,-0.056705102,-0.047957167,0.031993758,-0.037243348,0.12960479,0.04821002,0.0042304695,-0.017576383,-0.013746654,0.004668542,-0.01823126,-0.09117583,-0.09867901,-0.012349875,0.04071632,-0.09896311,-0.056173295,-0.080561884,0.077209845,-0.016735192,0.21627912,-0.007874658 +1.14.19.10,"The enzyme, characterized from the plant Limnanthes douglasii (meadowfoam), is involved in the biosynthesis of (5Z)-icos-5-enoate, an unusual monounsaturated fatty acid that makes up to 60% of the total fatty acids in Limnanthes sp. seed oil. The enzyme only acts on saturated fatty acids.",384,0.99999994,-0.08267086,-0.027318552,-0.047113195,-0.0030817743,0.11587719,0.05891018,-0.052488092,0.008918688,0.0060966434,-0.012663489,0.05724811,-0.08008577,-0.117697686,-0.046676826,-0.07153637,0.00146646,-0.02890666,-0.010979361,-0.107246265,-0.098822795,0.12835152,0.029496862,-0.03393062,0.055585586,-0.05083892,-0.009911531,0.015506627,-0.026422778,-0.0022889604,-0.08589363,0.015847152,0.035527833,0.035122946,-0.051615167,-0.01362284,0.09036218,0.0015341282,-0.084385455,0.057072956,0.025843525,0.06742065,-0.04296726,0.0016859982,-0.0115417745,-0.008631414,-0.041327007,-0.051224925,0.023390587,0.01123788,-0.03613948,-0.08658015,-0.08198756,-0.07251031,-0.052978206,0.003986324,-0.03482105,-0.012708419,-0.024547685,-0.07437451,0.002398434,0.10106604,-0.0019880363,-0.017500686,0.074015304,-0.055410225,-0.04162711,-0.032703668,-0.036062874,0.0055741714,-0.034701794,-0.030745689,-0.059884805,-0.018949935,0.021827998,-0.050296497,0.07262814,-0.059395105,-0.05107616,0.08399648,-0.0874481,0.024207992,-0.0068377866,0.010690743,-0.007142455,-0.0044595543,0.025022456,0.027666265,0.043407567,0.07556927,0.017590508,0.110852525,-0.04111866,-0.039245375,0.02895641,-0.061031263,0.042922888,-0.01995732,-0.05694727,-0.03971916,-0.031518955,0.021540519,0.03315677,-0.0054381215,-0.072637685,-0.062431358,0.0057397163,-0.017959563,0.014440472,0.0021573824,0.046055637,-0.08609565,-0.016116573,0.06239961,0.06688876,0.0045331125,0.01985461,0.022231255,-0.08274756,-0.015522296,-0.0048642564,-0.02167238,-0.008481295,0.025935864,0.027888123,-0.049033526,0.05377534,-0.0864953,1.2149656e-33,0.028948769,-0.036989693,-0.034469724,-0.058613256,0.018935181,-0.026856212,-0.04668281,0.023966393,-0.13547848,0.028229691,-0.043529946,-0.03998233,0.026230065,0.034347743,-0.0050549633,-0.023231966,0.02699076,0.10632507,0.03720469,-0.0155621115,-0.039393634,0.079006165,-0.09780937,-0.046802785,0.00017060117,0.039508328,0.0073041236,-0.026384763,0.06416383,-0.001758371,0.02937856,-0.014694328,-0.06308357,0.026370859,0.10878631,0.034530707,0.07079564,-0.037614718,-0.026305549,0.048856944,0.068779945,0.008510722,0.039668128,0.02611103,-0.015134312,0.014822409,-0.08127298,0.059938915,0.091199435,-0.016472409,0.059037235,0.043989427,0.036496427,0.0098857265,0.0150498785,0.018492296,-0.06488236,0.065645956,0.02411263,-0.0048759244,-0.054142755,0.048435543,-0.06440927,-0.0051847682,0.0070693763,-0.041519668,-0.09555786,-0.021722028,-0.023091393,0.13445961,0.07134636,-0.03400508,0.031516936,0.057834193,0.017122073,-0.05132305,-0.017494343,0.040697586,-0.09246504,0.03595547,0.0040409043,-0.022152746,0.008699538,0.011394557,-0.11189403,-0.0084374305,-0.023004409,0.087786265,0.033950493,-0.036976583,0.07410057,-0.06817464,0.0011364387,0.001103563,-0.039280172,-1.8986493e-33,0.058106463,-0.02735634,0.04765896,-0.03948843,0.013713724,0.08012576,0.0447828,-0.0019914499,0.0087247025,-0.025666215,0.08264709,0.035852943,0.087131836,-0.032027766,-0.033410408,-0.011850863,0.04565381,0.07776016,0.028528236,-0.06103263,-0.0038020322,0.0024228133,-0.032990918,0.09638847,0.057919264,0.08629932,0.0032844662,0.121839635,-0.08042227,0.0002664653,0.051993057,-0.027547069,-0.10888699,-0.042219814,-0.045824166,0.04410979,-0.026486501,0.023550402,-0.043128617,0.07539875,-0.06321712,-0.014297355,0.055149898,0.07478197,0.056291215,-0.035233434,-0.032726694,-0.010626152,0.03860677,-0.009308448,0.042339474,0.028440896,0.018121136,0.07083499,0.0641469,0.00210362,-0.012298664,0.03263467,-0.05060905,-0.043924246,-0.016531648,-0.020709157,0.031894118,-0.07852026,0.047451504,0.057043303,-0.028303662,-0.031640563,-0.025360718,-0.0055723963,0.08263372,0.055044748,0.031082707,0.042162266,-0.033340223,-0.04685269,-0.024877943,-0.07724137,-0.015694534,0.009896241,0.013793313,0.0011074428,0.042452753,-0.022620866,-0.07055353,-0.09822389,0.024915112,0.040398583,0.034880515,0.06505204,-0.022126656,-0.056309737,-0.094506375,0.028097456,0.07141903,-3.5952993e-08,0.008825589,-0.07407946,-0.00567631,-0.028248765,-0.05102417,0.022879764,0.024264894,-0.05584709,0.1074054,-0.03301123,0.033106986,0.048531093,0.052520663,0.12761462,0.06986282,-0.06741181,0.025189977,0.021007659,0.003367351,0.006316775,-0.04894192,0.0040854923,-0.04563707,-0.076692194,0.029100092,-0.05127951,0.05039306,0.029731594,0.05515523,0.044050265,-0.08277698,0.039939974,0.051246203,0.030495854,0.03728858,0.08482235,-0.061520033,0.012430847,-0.074073836,0.07938591,-0.0020343773,-0.063720554,-0.0012777539,0.00060856144,-0.008844435,-0.047647778,-0.012214373,0.06301451,0.02879705,-0.01512826,-0.019569792,0.025367348,0.02312115,-0.010112724,-0.043797474,-0.074659444,-0.01625658,-0.026814906,-0.037817314,0.012517471,-0.033898342,-0.01599255,0.19476448,0.026874017 +1.23.5.1,"Along with EC 1.14.15.21, zeaxanthin epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle for controlling the concentration of zeaxanthin in chloroplasts. It is activated by a low pH of the thylakoid lumen (produced by high light intensity). Zeaxanthin induces the dissipation of excitation energy in the chlorophyll of the light-harvesting protein complex of photosystem II. In higher plants the enzyme reacts with all-trans-diepoxides, such as violaxanthin, and all-trans-monoepoxides, but in the alga Mantoniella squamata, only the diepoxides are good substrates.",384,1.0,-0.026758438,0.026838565,-0.123429,0.014668912,0.10020221,-0.014615489,-0.007927432,0.058798783,0.06876544,0.037290763,0.122182205,-0.047229756,0.015176704,-0.024704235,-0.013301015,0.060117535,-0.058760457,0.006062099,-0.053385463,-0.058755264,0.097092934,-0.070282504,-0.009436988,-0.07163197,-0.010460819,-0.023074944,-0.09036663,0.021978617,0.07448708,-0.04626865,-0.014567753,0.0030388143,0.0012201886,-0.011564543,0.0072770608,0.121755384,-0.034903705,-0.17033698,0.008662827,0.010700859,0.022514584,0.023707906,-0.038953718,-0.034944575,-0.071877435,-0.024385283,0.024195423,0.006994948,-0.0952067,-0.01574318,0.046005797,-0.06832668,0.019009728,-5.2469957e-05,-0.012226977,-0.021083271,0.0052819606,0.031397026,0.013268451,-0.007887035,0.034226846,0.008582865,0.013241653,-0.043761864,-0.02564194,-0.05338266,-0.06616545,-0.06908938,-0.035551716,-0.07024616,-0.07197414,0.0047870046,0.06750491,0.064236484,0.018784724,0.016500821,-0.048321452,-0.04890423,-0.024011202,0.018004308,0.06289433,-0.007110167,0.008809213,0.07574534,0.0869594,-0.009156164,0.00096164714,0.03894284,0.0073376237,0.02425801,0.0031898443,-0.00064060785,-0.045877717,0.045311354,-0.044059847,0.09556932,0.05284582,-0.09518409,-0.045314364,-0.061667394,0.020245481,0.008502194,-0.025316015,-0.040392518,-0.014317686,-0.022745369,-0.010103372,0.12528554,-0.08738337,-0.01559485,-0.019048873,-0.018562285,0.037161667,0.005390412,-0.055183385,0.08058671,0.010200716,-0.032017242,-0.0836739,0.015040212,0.04244043,-0.010031616,0.002564161,0.042667072,0.018423807,-0.0010795665,-0.04346131,3.338318e-33,0.033380654,0.034157395,-0.033511475,-0.03661892,0.028326087,-0.038017906,-0.026462216,-0.027326213,-0.0006431806,-0.069116496,-0.081631064,-0.05801787,0.036249947,-0.013407377,0.006222582,-0.04821269,-0.057141487,0.0054555493,0.017359203,0.029075548,0.028171055,-0.04142019,-0.08899443,0.027597649,0.0261162,0.074141644,-0.007054463,-0.05016096,0.019956632,-0.025385445,0.04770924,0.0043044086,-0.07160007,0.050279472,0.112836406,0.10175655,-0.0067101573,-0.03771611,-0.028108675,0.0090573905,-0.0274378,0.07967546,0.018594258,0.009585165,0.061928473,0.016290484,-0.05850923,0.06657153,0.09801384,0.0076376763,0.043131746,-0.014663843,0.035349082,-0.014271753,-0.045807477,0.06831395,-0.013378062,-0.036007527,0.00095860683,0.027324349,-0.049368273,-0.006291059,-0.008570617,0.040690307,0.005039384,0.055246968,-0.09098806,-0.089614406,-0.040911365,0.08940226,-0.07576007,-0.08359655,0.04591839,-0.01214856,0.05981352,0.019129016,-0.014591759,0.05373763,-0.040624265,0.022413308,0.085484564,-0.008290578,-0.036288105,-0.11594447,-0.060828928,-0.039463036,-0.055019785,0.026448436,-0.0022621024,0.051393077,0.14573152,-0.012576404,0.0011075824,-0.002375856,-0.074195035,-3.247299e-33,0.056408484,-0.02414726,0.068100445,-0.025982497,0.034863714,0.07688703,-0.07139203,-0.049585003,-0.030830966,0.006629631,0.09954586,0.077558815,-0.061819598,0.06118923,-0.02763065,0.026844509,0.07366304,0.08129475,0.01831111,-0.03739395,-0.09420986,0.08855589,0.0034097573,-0.020471781,0.06525629,0.01768232,-0.000482798,0.0038694546,0.03604769,-0.0029539869,-0.067972854,-0.055429716,-0.046590324,0.024494775,0.05039556,0.030315608,-0.01818544,-0.021296691,0.005763432,0.121630035,0.015753001,-0.058620185,0.033157922,0.043126073,0.02284312,0.060086176,-0.092771165,-0.017586347,-0.041697852,-0.017216995,0.0109423,0.04616364,-0.06307566,0.046100944,0.062319066,0.057123303,0.022932718,0.027313387,-0.06549524,-0.0069260364,0.007296931,-0.03969627,-0.00458717,0.022010315,-0.0043083713,-0.0026857143,0.050577164,0.058464188,0.04634762,0.0060329544,0.096967764,0.031719867,0.035136096,-0.02604258,-0.008803146,0.0016308383,-0.064773865,-0.03430161,-0.058867395,-0.06463593,-0.009922948,0.05795993,0.04152106,-0.06662023,-0.03799538,-0.053594645,-0.043766987,0.10226298,-0.026325395,-0.065298565,-0.011571403,-0.026221693,0.022169227,0.033765532,0.11136008,-4.215685e-08,-0.09974396,-0.011200549,0.0078243455,-0.07351619,-0.010172789,-0.054599762,0.03729434,0.01177057,0.053396214,-0.014762455,0.023857411,0.09764142,0.054683346,-0.037993394,0.04217189,0.024278313,0.04701706,0.001992768,0.018434752,0.06210828,-0.11323139,-0.04682246,-0.12746556,-0.01844669,0.025522644,-0.021035902,0.08579898,0.033638332,0.031506874,0.0017313001,0.06397646,0.051156074,0.053226825,-0.03645729,-0.1298501,0.027434653,-0.06941455,-0.013764331,-0.048640348,0.0029910507,0.006005938,-0.0116570685,-0.012759703,0.0040972205,-0.015266004,0.064605415,0.067643166,-0.0049827755,-0.009640695,0.03424817,-0.0051564947,-0.0714945,0.02028918,-0.048107713,-0.07387181,-0.040427078,0.04312194,0.01073683,-0.0021409017,-0.00053552503,0.0076375823,0.038805068,0.1701646,0.04166757 +2.1.1.314,"This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98). The relevant histidine of elongation factor 2 is His715 in mammals and His699 in yeast. The order of the 4 methylations is not known.",384,1.0,0.02138838,-0.024451498,-0.09303094,-0.0872457,0.04033001,0.03307325,-0.06709155,0.047039237,-0.05956266,-0.035056982,0.06289461,-0.08956576,-0.08782556,-0.0049789064,-0.02400606,0.060759906,-0.107260354,-0.05291557,-0.013316087,-0.09508082,0.03692041,0.06097697,0.02643173,-0.04492109,0.036083866,0.025744855,0.019462185,0.009286503,0.069488384,-0.09442175,0.004748492,0.012493809,0.020795982,-0.061059408,0.055161163,0.066543,-0.015396489,-0.009577167,0.038982287,0.11281116,0.11188013,-0.00036871887,-0.0049709864,-0.060116157,-0.007829226,0.0631034,0.0133320065,0.010798467,0.04020523,0.024930213,-0.066424996,-0.08878005,0.051618166,0.014621681,0.025425814,-0.05803532,-0.037222035,-0.017346106,0.001037707,-0.011324569,0.04199905,-0.004373584,-0.022723354,-0.017424274,0.04641823,-0.062387254,0.07471874,-0.1226125,-0.03140456,-0.0018637005,-0.048076425,-0.056449514,0.009397112,0.0991349,0.009974261,-0.0013267925,-0.0032766494,-0.055320375,0.030531827,-0.0141753815,-0.021569947,-0.017577581,-0.0041381805,-0.008172225,-0.04855909,-0.03486648,0.01194186,-0.035881337,0.036101177,0.019145489,0.040637597,-0.059957065,-0.046052188,-0.08546945,-0.07734583,0.060386535,0.05621868,0.022180894,-0.022333678,-0.0011296453,0.007932989,0.046570573,-0.10017028,-0.016119832,-0.003415263,0.027292117,0.0024280273,0.10326232,-0.0071310117,0.008336649,0.0017821827,0.0031534461,0.058431048,-0.057098705,0.0016501994,0.0597218,0.023942387,-0.0420702,-0.017430568,-0.017765524,0.027434016,0.05691753,0.096300356,0.094247036,-0.027293835,-0.05971209,-0.12020252,1.4926086e-33,0.10027191,0.052697472,0.00551163,-0.010523028,-0.040310543,0.012255695,-0.09550756,0.029506298,-0.008183413,-0.106820695,-0.062635995,-0.114257686,0.10872345,0.0036889946,-0.08285045,-0.051794514,0.055526875,-0.018865881,0.067099735,-0.05236914,-0.046295237,0.07249599,-0.008506392,-0.02565628,-0.0006853731,-0.0048969123,0.04902479,-0.0071435454,0.037648063,0.0024318793,-0.018171847,-0.0021103031,-0.14303266,0.03562333,0.06584933,-0.028514398,0.020442704,-0.0738112,0.037937753,0.05546849,0.03542876,0.056559388,0.051654626,-0.08707507,-0.0015945823,-0.06696831,-0.012967158,0.012600957,0.062469985,0.00038539228,0.04390795,0.0113656605,0.1404325,-0.018409142,-0.01897924,0.015163142,0.0022421211,0.005050118,0.04532458,0.10522431,-0.050364338,-0.00052546506,-0.0407196,0.072785616,0.0066784173,-0.028993553,-0.07156151,-0.035040043,-7.343828e-05,0.07073628,-0.036092743,-0.035183784,0.09068218,0.019735418,0.013684402,-0.088200435,-0.096331276,0.021045916,-0.021707103,0.013984429,-0.017740363,-0.004263491,-0.02986451,-0.011133646,-0.05169532,-0.019908713,0.026885899,-0.030995687,0.007518259,0.054306664,-0.047226943,-0.057731677,0.030903976,-0.008831354,0.079241954,-3.333628e-33,0.024291115,-0.09638588,0.048333254,-0.065749764,-0.026660684,0.034757912,0.08469716,0.060857337,-0.058411554,-0.04350641,0.11474685,0.023191499,0.02277623,-0.08191014,-0.0035265158,0.061077617,-0.0007813372,0.10583315,0.034325182,-0.005395471,0.017658347,0.033870157,-0.02491331,0.0606228,0.02729326,0.014861905,-0.014516458,0.06293379,0.037828684,0.03913662,-0.08606135,0.0017838338,-0.033524085,-0.017953308,0.023974312,0.028790522,-0.06093612,-0.008111459,-0.02220631,0.021491995,0.015524206,0.046565868,0.01697429,0.037976507,0.0627268,0.09191011,-0.061416853,0.07820333,-0.0008160548,-0.06321169,-0.03983534,0.012601543,0.04361564,0.052656334,0.06623854,-0.010588997,0.024032786,-0.0015192678,0.05892955,0.006488169,0.00047510312,-0.06739284,0.01033321,-0.07822824,0.055184606,0.04073642,-0.08234823,-0.016633889,0.018814016,-0.026094856,0.027177034,-0.029390823,0.06251787,0.011747998,-0.044559583,-0.053126056,-0.013062396,-0.03484937,-0.005906109,-0.059642762,0.028902618,-0.03702523,0.0077854656,-0.038687594,-0.048871018,-0.06089308,0.057061758,0.06235285,-0.025897333,-0.06348959,-0.013683352,-6.906846e-05,-0.053637322,0.09139272,0.09920487,-3.9395704e-08,0.048247553,-0.09649658,0.061414752,-0.03587195,-0.027490975,0.085640155,-0.03097265,0.010782335,0.0335013,-0.019545324,0.029028226,0.108906925,0.03826054,0.023363983,0.023866689,-0.024378212,-0.029794276,0.028195933,-0.006011044,0.0071384385,-0.041508775,-0.023852076,-0.021608116,-0.018617634,-0.015157846,-0.011143602,0.018375406,0.09978108,0.024174657,-0.117370576,0.026646512,0.013203052,0.04913391,-0.017991913,-0.07133725,0.0399494,-0.04571345,0.003952046,0.060572717,0.0052915807,0.046742417,8.956196e-05,-0.11873097,0.007607222,0.0031172268,-0.0027782505,0.0064723883,0.050951198,-0.031844337,-0.065094166,-0.052242927,0.0076692128,0.07050542,-0.013572681,-0.03926202,-0.05680834,-0.10244862,-0.048765875,-0.018974643,-0.020371975,0.08642598,0.01314305,0.13592194,-0.037363146 +2.1.1.315,"The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the antitubercular drug rifamycin B. 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The overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta-enoyl 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+2.3.1.245,The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule 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+2.3.1.246,"The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin. ",384,1.0,-0.05393319,-0.011789393,-0.11507215,-0.07892142,0.0593953,0.028105127,-0.03925958,0.025183685,0.07737565,-0.02685507,-0.016709896,-0.023754114,0.063283965,0.025228688,-0.04950872,0.0017300197,-0.09829043,0.01232046,0.008779775,-0.046211574,0.013512162,0.08402847,0.0063548377,-0.022036888,0.053214155,-0.012859871,0.08348098,0.031720426,-0.0522602,-0.02182964,0.030893559,-0.06273932,-0.02235122,-0.03908087,0.045140255,0.047762793,-0.094618306,-0.0042979317,0.14137301,0.010722312,0.017623238,-0.007916983,-0.07501438,0.006761684,-0.0284268,-0.011403274,-0.023583325,-0.023948649,0.049312722,-0.016706394,-0.036841463,-0.053194307,-0.038048703,0.06783106,0.035563037,0.047019016,-0.032498963,-0.057878356,-0.0625989,-0.046324085,0.022955082,0.021045873,0.044567794,-0.032131474,-0.07807496,-0.057705324,-0.02201033,-0.0678543,0.05328915,-0.007810397,-0.06709234,-0.06749378,-0.016590336,0.033953264,0.024845129,-0.030933987,0.0033567955,0.008924325,-0.0046336614,-0.06561646,0.021806266,-0.057577644,-0.015367542,0.14633973,0.024116851,-0.04903425,0.113317035,0.01023136,0.07825231,0.05929326,0.020966383,-0.0065579633,-0.042390678,-0.078500405,-0.033944566,-0.038937464,-0.014157924,-0.04618423,6.172024e-05,0.010210873,0.0031845788,0.028610477,0.056812316,-0.10601881,-0.02321278,0.0042058397,0.02229917,0.04971973,-0.0118796,-0.018974345,0.008990469,-0.026851956,0.005836345,-0.019566314,-0.06440166,0.079217084,0.09291576,-0.07164952,-0.055305406,-0.00014846503,0.026055446,0.024096992,0.08648489,0.06695132,-0.02221194,0.046658788,-0.13225679,1.1405763e-33,0.009104881,0.042918112,-0.025834749,-0.0014690591,0.058662962,-0.03317648,-0.0666647,0.007326978,-0.008979236,0.017701056,-0.13524228,-0.10499454,0.021743277,0.063679785,0.003694919,0.028110506,-0.02101241,-0.011095836,0.012862149,0.02513524,-0.012417851,0.05977535,-0.020793717,-0.020169746,0.030017026,0.012634361,-0.0016085845,0.026261907,0.11087095,-0.01445088,-0.026070526,-0.050030712,-0.033532016,-0.055477258,0.07663009,0.016911104,-0.02277111,-0.022262158,0.0953634,0.05625507,0.106203675,0.016768195,0.015158395,-0.03945753,0.018100062,0.05780911,-0.03248647,0.089145415,0.027630253,0.036373645,0.07809301,-0.08462268,0.09428008,-0.040449034,-0.038372934,0.027525175,-0.025240665,0.047625612,0.053320613,0.05017117,-0.011772397,0.011544674,-0.007628098,0.02280877,0.05089792,0.00876702,-0.022161003,-0.036909446,-0.029287556,-0.0393161,-0.08923181,-0.070607394,0.06064091,0.017987384,0.026366897,-0.035449736,-0.082919985,-0.006123022,0.084416725,-0.0053053764,-0.013823551,0.03875352,-0.012875926,-0.052769475,-0.019771839,0.01808114,-0.01902171,-0.04152084,-0.022948626,0.059428275,0.0066347024,-0.0563942,-0.07300515,0.044970036,-0.020971712,-3.6289645e-33,0.034454975,-0.1340983,0.03798187,-0.031950146,-0.013169984,0.053709738,-0.033422064,-0.013889984,0.051905207,0.03525787,0.08488922,-0.03451162,-0.00315034,-0.061774235,0.023363562,0.01772838,-0.00040884892,0.061748613,-0.0074207443,0.0121912975,-0.04302173,0.051561862,-0.010793959,-0.038701177,-0.018958509,0.06624752,-0.015999233,0.09867899,0.04082278,0.04189846,-0.01849686,-0.014497841,-0.018125692,-0.031623628,-0.057490777,0.091106,-0.00048429478,-0.026560796,0.00047064162,-0.011454153,0.028259428,0.018797576,0.023744797,0.04504508,0.018643139,-0.0043414184,-0.0507395,0.0072944313,-0.027453879,-0.077895604,0.014627308,-0.04985669,0.03053153,0.02673613,-0.0156944,0.048045665,-0.014656287,0.026922861,0.042231534,-0.043186896,-0.033882644,-0.066842094,0.034150545,0.010713009,0.014355672,0.05005084,-0.07332859,0.02262396,0.10779531,-0.07843177,0.03499812,0.04253379,0.012400974,0.042473145,0.019193761,0.02743882,-0.04806072,-0.03316047,0.030586755,-0.027242655,-0.03355328,0.014648594,-0.07469865,-0.014238918,-0.11453052,-0.08119945,0.02481854,0.09596684,0.0028048574,-0.031090531,0.028833378,-0.0052110874,-0.06876267,0.09801216,0.0068856147,-3.771025e-08,0.06339997,-0.055672985,0.054684833,-0.030536942,0.0024824871,-0.01865025,0.018550768,-0.0026991344,0.03383257,-0.0008471199,-0.006051527,0.0900308,-0.03418761,-0.028227732,-0.0337667,0.060204394,-0.07695435,0.09884306,-0.010183065,-0.026106482,-0.03511106,0.066046596,-0.11227203,-0.04089192,0.079300396,-0.0556786,-0.018980386,-0.007292672,-0.08665772,-0.05902227,-0.006531466,0.028286202,-0.03709236,-0.065180555,-0.06678056,-0.025168449,-0.07109747,-0.06151209,0.09327147,-0.014070267,0.09965473,0.013689675,-0.097289644,-0.009258505,-0.035307057,0.034623463,-0.010337485,0.039965495,-0.02468055,-0.032553293,0.030855205,0.06507271,0.01877186,-0.060123414,-0.09746195,0.010707796,-0.030929724,-0.0975256,0.00553685,-0.07665627,-0.059564006,0.037376076,0.23714171,-0.007344995 +2.7.1.187,"The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose. 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SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose. ",384,1.0,-0.107837446,-0.029546956,-0.1498913,0.0067699873,-0.020532751,0.027613472,-0.050691962,0.0507828,0.06836167,0.07040726,-0.006701526,-0.06985501,-0.08445623,-0.011161052,-0.07517887,0.042768236,-0.036136407,-0.046217334,-0.016756192,-0.0758303,0.08859979,0.032208364,-0.043980848,-0.0056906985,0.028781753,-0.04542118,-0.0069949497,-0.038770694,-0.048345808,-0.07904159,0.034335356,-0.07388727,0.091981396,-0.043735735,0.06750891,0.052181806,-0.023524752,-0.08609307,0.08277355,-0.029508132,0.027796667,-0.021446416,0.020302108,0.04704937,-0.058848348,-0.01975821,0.004242869,0.063551575,0.03141658,-0.018115062,-0.08959308,-0.07886366,-0.10833002,0.0049385354,0.049909815,0.011376021,-0.020561742,-0.08202589,0.027836233,0.03994421,0.049051,0.012286137,-0.0002311139,0.04638678,-0.07876704,-0.08014618,0.07540809,-0.07810572,-0.031245096,0.017223988,-0.047383647,-0.047392607,-0.012122836,0.0202537,0.030869173,0.003837532,0.0016023983,-0.0025764639,0.018605974,-0.016467353,0.002515217,-0.010183142,0.033832625,0.061641887,0.011839279,-0.04910128,0.02779018,0.010711773,0.09557511,0.024781333,-0.015938979,-0.02548734,0.019832816,-0.055028956,-0.037071325,-0.00073285215,0.025783151,0.017020477,0.049159296,-0.01734689,-0.022320878,0.05107896,0.036271393,-0.081211396,-0.104590744,0.021001684,0.023389569,0.10451409,0.026702786,0.06893894,-0.04999619,0.0030583818,0.0046035037,0.0017889951,-0.037209183,0.056026157,-0.015924044,-0.08771507,-0.0037546658,-0.008994057,-0.004950693,-0.01389088,0.040941373,0.07879794,-0.064173475,0.054566234,-0.094843835,-1.055991e-33,0.05479648,-0.033604857,-0.00068279373,-0.017788162,0.04034668,-0.03569265,-0.025825968,0.005970977,-0.03381887,-0.016004877,-0.060607493,-0.1232334,0.05155718,0.07222789,0.011320991,0.037373748,-0.015148046,-0.07311173,-0.003944584,0.03966654,-0.026645405,0.06364354,-0.052022573,0.037572283,0.055985376,0.018878503,-0.042796068,0.013571727,0.0065244487,0.012934018,0.07849091,-0.04853877,-0.105315015,-0.013715644,0.085709006,-0.03515576,-0.0021690363,-0.023740383,-0.025939764,0.02621144,0.023101231,0.03352579,-0.0012124557,-0.0029802653,0.07932684,0.018656693,-0.03608238,0.1055509,0.06829517,0.10773052,0.0010829786,0.0061759087,0.112004414,0.021400414,-0.053697277,0.0772172,-0.098195754,0.016823504,0.039147228,-0.003407857,0.017966628,0.04336418,0.024535716,-0.00024739705,-0.014446533,0.03721605,-0.02815465,-0.054125648,-0.024176357,0.068652205,-0.057938203,-0.0424516,-0.009437795,0.0023587458,0.027190398,-0.031842,-0.052088626,-0.061551772,-0.009659775,-0.0130084455,0.018010972,-0.016886462,0.026327305,-0.06513852,-0.06480225,-0.020733872,-0.041133832,-0.025136597,-0.056957144,0.055387307,0.05396374,-0.07550942,-0.084749475,0.08027214,0.02111105,-1.8938024e-33,0.10868431,-0.10847928,0.039803475,-0.049443386,-0.08884812,0.055800095,0.0072525637,0.0038614706,-0.02943125,-0.033352196,0.03348595,0.052425604,0.04188531,-0.03753337,0.0062344777,-0.029407427,-0.051014267,0.07496914,-0.0068580154,0.061060287,-0.024108779,0.091716506,0.09053701,-0.07177677,0.08691574,0.013193091,-0.030244565,0.11097521,0.008218935,0.011754395,-0.017537847,-0.006291941,-0.025195338,-0.061835196,-0.122141555,0.025052128,-0.034801353,-0.029933529,0.055163395,-0.00596903,0.03256806,0.06286412,-0.030628055,0.028159417,0.024565432,0.06866736,-0.047651,0.017480642,-0.03493637,-0.14938717,-0.013606868,0.020961953,0.049288925,0.03794202,0.06483399,0.084115714,0.016687142,-0.007813116,-0.005661127,-0.07151461,-0.0183728,-0.005648051,0.08446655,0.0033375062,0.10013124,0.06773139,-0.027482908,0.035896394,0.04260614,0.01693035,0.010326275,-0.0040202173,-0.09926678,0.025234591,-0.016152654,-0.034437437,-0.07528109,-0.05565603,-0.05812654,0.000101358586,-0.014843189,0.00391432,0.044295926,-0.03107645,-0.058974855,-0.03776758,0.071261235,0.07852859,0.023088068,0.1142647,-0.025213463,0.009512855,-0.0056625926,0.101711564,0.07307077,-3.0580185e-08,0.034804076,-0.0022886992,0.052522812,-0.04606059,0.018987477,0.034963794,-0.049909092,-0.026280606,0.0050685704,0.037266977,-0.03244702,0.050014522,0.038061973,0.062239714,0.012369705,0.010724019,-0.025571737,0.0061667175,0.00060548494,0.036541343,-0.050028455,-0.002681716,-0.053224515,0.08654815,-0.030944359,-0.071998574,0.022403903,0.015359491,-0.023029944,-0.0007854425,-0.109773844,0.08126752,0.017525708,-0.050933715,-0.0770637,0.03249086,-0.045505557,-0.09491359,-0.010532784,-0.021855764,0.043121018,-0.010139984,-0.023922345,-0.0004126366,0.048273407,0.03000827,0.017435787,0.011805812,-0.070464864,-0.022953322,0.04243641,0.03737426,-0.06741697,0.0048599173,-0.10306557,-0.02198725,-0.07828529,-0.05164125,-0.016141707,-0.014341746,0.025396552,0.014798184,0.10681794,-0.08803323 +2.7.4.29,An inner-membrane protein. The activity of the enzyme is regulated by PmrA. In vitro the enzyme can use diacylglycerol 3-diphosphate as the phosphate donor.,384,1.0,-0.08257708,-0.070745796,-0.05643854,-0.06510843,-0.0368927,-0.025066704,0.037516486,0.0609875,0.04290837,0.016270457,-0.023380987,0.006804093,-0.06477543,0.07819722,0.0649957,0.068377785,-0.00013517795,0.02107844,-0.012377985,-0.030410651,0.15124315,-0.025151914,-0.03037808,-0.082625024,-0.054116376,0.0041610245,0.04366983,-0.008685472,0.029098786,-0.05579302,-0.08369151,-0.0370216,0.03156337,-0.07400375,0.08251588,0.055770297,-0.081480496,0.034463726,-0.050296247,-0.083805054,0.1286884,-0.03440258,-0.04626645,-0.03584553,0.007052921,-0.0068626176,0.008030395,0.013734193,0.041760463,0.023445453,-0.063777514,-0.053392168,-0.03827596,-0.024786603,-0.043501586,-0.020731626,-0.024168042,0.029320626,-0.0026909965,-0.047051847,0.005460235,0.0314617,0.041405067,-0.023589185,0.07801936,-0.14720227,0.006948415,0.013952234,0.060506184,-0.072490856,-0.013045018,-0.060512636,0.027849177,-0.05059793,-0.0042200545,-0.004123766,-0.035854805,-0.0024618497,0.04618135,-0.0060955486,0.10977721,-0.005173075,-0.019966241,0.12939872,0.057885524,0.06995347,0.016299434,-0.007967364,-0.051084466,0.0074244593,0.0006734826,-0.052396115,-0.0661445,0.05160476,-0.08009841,-0.034006238,-0.05968623,-0.036100894,0.029571839,0.037156586,0.061083358,0.017484907,0.013965834,-0.03800433,-0.08283576,0.017901868,-0.01603843,-0.001375009,0.037332166,0.0031178999,-0.020245092,0.047026087,0.095563635,0.0013958513,0.014759461,0.06739967,-7.447466e-05,0.00161322,0.07419456,0.008347369,-0.04467495,-0.022828495,0.035566136,0.031429805,-0.0019704807,0.12200287,-0.0977943,-1.7026038e-33,0.022109177,-0.008781288,0.049799997,-0.042267114,-0.10644546,-0.015176285,0.0161041,-0.033438932,-0.028720213,-0.06735007,-0.012156431,-0.14312671,0.055486303,0.035353053,-0.028338311,-0.025582058,-0.016869867,0.0006071339,0.10523653,-0.0060089245,0.0068804706,0.043668605,0.0072186836,0.0037068422,0.08166203,0.007389143,0.004375086,0.014300053,0.064526685,0.016214984,0.049133062,-0.06277178,-0.041421387,-0.0009142303,0.021464486,-0.036718484,0.009675237,-0.060194045,-0.07135178,-0.021147389,-0.07134208,-0.04144452,0.008025164,-0.015925994,-0.000144163,-0.05441386,-0.089505,0.115496755,-0.00032300534,-0.06098567,0.06769019,-0.070008,0.056057297,-0.05599629,-0.04607145,0.0115249995,-0.054510374,0.00880246,0.039880037,0.006910586,0.08285081,0.018401835,-0.060640972,0.066844836,0.054174565,0.04867163,-0.082152285,-0.009479865,0.0155415125,0.08383588,-0.04678585,0.0043799696,0.022274578,0.033072162,-0.000646292,-0.03518602,-0.02823896,0.061500747,0.032978293,0.011916203,0.08186761,-0.015426433,0.008571379,-0.012213092,-0.056141913,-0.0015987161,0.030996444,-0.075452514,0.007739596,-0.017852405,0.04504927,-0.06922428,-0.068849444,0.1115951,-0.044842783,-1.1603546e-33,0.060894374,-0.01758423,0.07997655,-0.053488046,-0.0027671775,0.008752994,0.0454723,-0.023647483,0.056745425,0.03212143,0.027876992,-0.044761375,0.08318856,-0.051920857,0.017582273,0.0307899,-0.08964722,-0.0065275636,0.0009202346,-0.0024594087,-0.043741185,0.066701554,0.044382803,0.10880297,-0.04064095,-0.03136586,-0.0692427,0.04648373,-0.028019607,0.042996235,0.007210477,0.06660009,-0.07688011,-0.04810093,-0.08770418,0.000865388,-0.015433927,-0.084553614,0.0196605,0.02693864,-0.044052538,0.084601685,0.07974975,0.0074599385,-0.019212237,0.071023434,0.007398581,-0.015185887,-0.013949501,-0.061050918,-0.031000717,-0.014508361,0.043476146,0.026718456,0.045712076,0.07263228,0.010647541,0.045668412,0.02460086,-0.009370043,-0.049129255,-0.13246292,0.050062273,-0.019441828,0.033622034,0.11821289,0.04259463,-0.03902292,0.035908908,0.013620119,0.04543924,0.08094015,-0.043837395,0.061383054,-0.029293647,0.020898625,-0.1010061,-0.018874278,-0.007950693,-0.040234115,-0.028588763,0.007587607,-0.04897016,-0.07482234,0.04944856,-0.010319285,0.045177434,0.039286777,0.029195752,0.0040549138,-0.0222682,-0.019715019,-0.0684215,-0.009219946,0.025022287,-2.9966934e-08,0.06568462,-0.07742436,0.016784143,-0.028679986,-0.09573938,0.00020536462,0.017864855,0.016947804,0.056652445,0.02242366,-0.027896116,0.03545647,-0.018877255,-0.05732005,0.01986485,0.02714438,0.036184896,0.054626744,-0.003960134,-0.12370631,0.035113856,-0.020395325,-0.07550229,0.10552125,0.056776788,-0.07233442,0.021157026,-0.011348856,0.0032765102,-0.021309296,0.0050812433,0.040159278,0.03638806,-0.05445424,-0.10181499,0.10653828,0.03923036,-0.01257996,-0.012224075,0.04788542,0.05509707,-0.018623907,-0.031731255,-0.048619594,-0.0061781798,0.022291193,-0.01241202,0.03675284,-0.08221397,-0.0054424177,0.05206006,-0.023733454,-0.016664444,-0.027225776,-0.07445599,0.003341899,-0.07404836,-0.0056376145,0.027774228,-0.019393826,-0.0066115395,0.07274699,0.1378035,-0.06673207 +3.1.2.31,"Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.",384,1.0,-0.056982473,-0.065451674,-0.0854064,-0.07246361,0.10366562,-0.01644808,-0.12578146,0.0705353,0.023712376,-0.07367921,0.0021211184,-0.10640491,-0.030892469,-0.033317097,-0.040243912,0.062007368,-0.061380956,-0.0116852205,-0.01381039,-0.004432582,0.074765965,-0.01819641,-0.04676757,0.015872268,0.028202673,-0.014637175,0.074036166,0.0115276575,-0.012885549,-0.022783328,-0.045184806,-0.004550495,-0.023162933,-0.058558747,0.026828162,0.046383716,-0.040320594,-0.038742788,0.11362658,0.03747336,0.093784034,-0.03236986,0.0038369545,-0.034386337,-0.04740522,-0.018831521,-0.021212999,0.007054257,0.0013270361,0.014696133,-0.10351602,-0.04494327,0.03346119,0.030126784,-0.06427845,-0.0012034893,0.018896155,0.07956684,-0.015218193,0.048771344,0.0075438563,0.03451389,0.01584407,-0.023139752,-0.027348438,-0.07308462,0.057011142,-0.013513025,0.008521947,-0.031150838,-0.078252465,0.036094725,0.01283467,0.046979856,0.06545104,0.09044585,-0.0032831375,0.003950628,-0.0025029238,-0.053471036,0.12414849,0.010755355,0.037528325,0.102064595,0.021844603,-0.0485533,-0.0074092434,0.04649678,0.0018237536,-0.0013499818,0.02472429,-0.008161256,-0.061667103,-0.025180385,-0.075603716,0.04431851,0.022312261,0.028456375,-0.02088474,0.011363565,-0.010996227,0.04569687,0.009464407,-0.073067814,-0.055173308,-0.026768899,-0.033641357,0.053534888,0.007402124,-0.06947082,0.057431772,-0.042167727,0.0699626,0.018579714,-0.037926555,0.056575835,-0.019430298,-0.08324178,-0.038707763,-0.03160178,0.047161993,-0.083015084,0.047842108,0.06620999,-0.051178295,-0.0274083,-0.09166262,3.944539e-33,0.1302818,0.028617147,0.008835853,0.014895305,-0.007215696,-0.016492436,-0.07873933,0.02889056,-0.0477111,-0.060954608,-0.026484601,-0.06841006,-0.025966533,0.03280166,-0.0059964587,-0.036390886,0.061601732,-0.036403123,0.03780929,0.013135099,0.048012566,0.038407914,-0.089306206,0.011163932,0.040572707,0.17016405,0.024172463,-0.024657793,0.011971135,0.018015837,-0.04789105,-0.100355774,-0.0039334088,0.08067662,0.051722046,-0.043195438,-0.07882477,-0.023769798,0.04148287,-0.030626945,0.04327466,0.026032906,0.0123190805,-0.08042284,0.063361585,0.009214118,-0.028493525,0.042014178,-0.019235132,0.0343162,0.03103157,-0.022129279,0.08426686,-0.037326045,-0.02520136,-0.039124157,-0.07384502,-0.020229839,-0.002982573,0.014363229,0.045188744,0.074924044,-0.08394199,0.060100365,-0.08495593,-0.008736179,-0.036096774,-0.075104564,0.045042723,0.00842069,-0.014089759,-0.009701289,0.03926385,0.009108736,0.026537573,-0.023022585,-0.064650126,0.05552229,0.0013708837,-0.013715383,0.059720363,0.028147364,-0.04537716,-0.04480404,-0.06262279,-0.0016166153,0.013235271,0.04769012,-0.069830135,0.015888551,-0.018391386,-0.080751956,0.044884138,0.052875545,0.059749536,-4.9016307e-33,0.06469899,-0.09951136,0.060220666,-0.09658916,-0.07085487,0.08179281,0.01898596,-0.017553853,0.055662848,-0.024433143,0.038762085,-0.04098593,-0.035294782,-0.038234584,0.058694456,0.028460987,-0.029331898,-0.049476095,-0.03640029,-0.019690685,0.032240506,0.025128735,0.058227073,0.07419196,0.06582183,0.023793539,-0.026709745,0.0499302,0.009584344,0.11657406,-0.093076766,0.014539086,-0.042711794,-0.03613099,-0.09924165,0.0009652019,-0.0557277,-0.019092843,0.0012247596,0.06251814,0.013395397,-0.04432501,0.032861605,0.044849966,0.0030220293,0.104397416,-0.05535587,-0.05947494,0.08367124,-0.05767023,0.013948572,0.007873346,0.013575963,-0.031143468,-0.0050885687,0.049018238,0.031143907,0.031028243,-0.06514156,-0.09740329,-0.048387278,-0.10137,-0.047313582,0.01926347,-0.035390433,0.12741505,0.0032125344,0.09551051,0.05208377,-0.0481234,0.10959034,-0.0025225214,0.023732694,0.052664224,-0.012752145,-0.02492423,-0.07480624,-0.044426743,-0.0076465225,-0.019548716,-0.016681446,-0.021504672,-0.056000605,-0.060511164,0.020928513,-0.06340696,0.05071284,0.049020395,-0.046306185,-0.013364469,0.04742021,0.06725041,-0.040101793,0.06788293,0.04878335,-3.6667753e-08,0.061842218,-0.10800819,-0.016888388,-0.03735353,-0.026192112,-0.0071568536,0.04735874,0.033169303,0.01763006,0.03055157,-0.0042875395,0.030396286,-0.00985767,0.054494165,0.03302155,-0.0007726089,0.0111747375,0.07376892,-0.005246009,-0.002662067,0.013081998,0.012194283,-0.0969127,0.021179512,0.01765633,-0.057701904,-0.04221055,-0.09477984,0.035825763,0.043513674,-0.007145475,0.030339763,0.0095714955,-0.027344016,-0.030262534,0.03640798,-0.0127022015,-0.050836135,-0.03935339,-0.031185884,0.05911808,0.08605181,-0.092739224,0.016197683,0.020481123,-0.02014401,0.06212427,0.017749533,0.040538974,0.021716272,0.01915624,-0.02352361,0.050037093,-0.03393814,-0.08709104,0.045360483,-0.02875494,-0.023723131,-0.0052134767,-0.038668077,-0.00029165152,0.0075086094,0.21216668,0.0036984945 +3.1.3.97,"The enzyme, characterized from the bacterium Chromobacterium violaceum, has similar catalytic efficiencies with all the bases. The enzyme has similar activity with ribonucleoside and 2'-deoxyribonucleoside 3',5'-bisphosphates, but shows no activity with nucleoside 2',5'-bisphosphates (cf. EC 3.1.3.7, 3'(2'),5'-bisphosphate nucleotidase).",384,1.0,0.003163242,-0.091406174,-0.10392413,-0.029176071,0.03499734,0.053072818,-0.052863102,0.053778335,0.07158675,0.045090962,-0.03500631,-0.07507529,-0.05737387,0.08237992,-0.019728383,0.047098447,-0.044931274,0.010624869,0.06334894,-0.03953239,0.051906385,-0.039348483,-0.015144237,-0.015746707,0.055716872,0.04222936,0.01833927,0.0031938688,-0.013737263,-0.0657532,-0.033366155,-0.041113347,0.12845758,-0.08210116,0.11101787,0.08374742,-0.06726941,-0.10759924,0.047815852,-0.0032094293,0.035588242,0.06956226,0.009269381,-0.019393222,-0.07890195,0.0067636357,0.030493496,0.04412472,0.025393343,-0.026135774,-0.015027234,-0.091426186,-0.049519733,-0.03156506,0.005146636,0.064193174,-0.011784883,0.013187382,0.031311806,0.05713974,0.03813323,0.0056113508,0.08544209,0.0082512535,0.033138353,-0.013407069,0.015310293,-0.050090984,-0.012013568,-0.04272506,-0.044406496,-0.044625957,-0.013003807,0.016876949,-0.04311335,-0.008314775,0.014080901,-0.020712603,0.05223011,-0.06171467,-0.100617334,-0.07757333,0.019937716,0.01208231,0.018945253,0.020548625,-0.013856054,-0.011794971,0.050445244,0.033232972,0.048751723,0.03890989,0.02933202,-0.15087643,-0.0051384484,0.04155801,-0.01206684,0.06812418,-0.032758847,-0.032544527,0.019488895,0.1085987,-0.044058774,-0.114001006,0.007979498,0.059598163,0.01084151,0.049993996,0.024205385,-0.00412597,-0.025798945,0.032180127,-0.020780182,0.018617803,-0.018500993,0.048697628,0.053514212,-0.08057392,-0.06653258,0.0538755,0.056938782,-0.1501925,0.06205395,0.0391113,-0.050785784,0.065659046,-0.06773824,3.7446577e-33,0.037764043,0.04458944,-0.01080562,-0.03724361,-0.032216158,0.03453051,-0.058724698,0.032767415,-0.06345445,-0.008826234,-0.10136465,-0.015903419,0.10657967,-0.0161309,0.01762544,-0.018078456,-0.0075872494,0.036742497,0.048546016,0.002168456,0.044369582,0.029938094,-0.024922013,0.042161137,0.073109336,0.037034974,-0.039826836,0.026802761,0.04250027,-0.034201805,0.014774703,-0.023148667,-0.11531794,0.001216645,0.09594601,-0.02560498,-0.053730078,-0.019603254,-0.052567996,0.046956517,0.010372232,-0.002340677,-0.017117936,-0.046984363,0.047820777,-0.063371904,-0.017161557,0.022489144,0.08669397,0.024834685,0.022667158,0.014575957,0.119948216,-0.09299214,0.0040182425,0.017055167,0.06737068,0.02099023,0.06525345,0.034770094,0.008203294,0.015531258,-0.038098153,-0.016460303,0.007073262,0.029852195,-0.053745646,-0.08111991,0.055913538,0.0685542,0.00082878006,0.0061720344,0.020708218,-0.0077021127,-0.009350662,-0.04508508,-0.067479126,-0.061121374,-0.016317254,-0.010356365,0.033483922,-0.03676308,0.082213685,-0.08666775,-0.019224843,-0.0063461885,-0.05058682,-0.0730777,-0.04155429,0.013311333,0.08398582,-0.044498377,-0.1134126,0.033416588,-0.004351878,-4.2061998e-33,0.0802024,-0.059292596,0.0017782013,-0.08488094,-0.069379516,0.061133005,0.045000155,-0.06296281,-0.00041671155,-0.008032519,0.090309836,-0.022869525,-0.015331986,-0.033739224,0.00819205,0.07210293,0.047441993,0.06528798,-0.0116013475,-0.02942869,-0.0081813745,0.090046726,0.04756428,0.012126397,0.046518836,0.009825559,-0.03116875,0.015833564,0.032650203,0.0045570293,-0.034056228,0.01812916,0.003259496,-0.041038543,-0.0024028772,0.035342164,-0.04279834,-0.0002222949,0.026735788,0.007499674,-0.016904654,0.08769204,0.020733895,0.07364333,-0.025624938,0.03796112,-0.060799677,0.033014584,-0.048811037,-0.05270778,0.04319933,-0.0444949,-0.024782468,0.02082268,0.06608374,0.05898581,-0.0006617736,0.02555519,-0.06657959,-0.024683937,-0.052167665,-0.0535747,0.031470634,0.004510413,0.073052146,0.11189143,-0.069789015,0.08539653,-0.00332194,-0.035578243,-0.0004777039,0.0014820024,-0.039542854,0.029704876,-0.07776544,0.009011162,0.021563139,-0.013608112,0.005395427,-0.05931656,-0.009083264,0.010112968,-0.041430645,-0.089728,-0.012207873,-0.04021783,0.005173809,0.08874341,0.00039303172,0.09226753,-0.024997253,-0.011784329,0.0063708248,0.014135598,0.117235534,-4.7655853e-08,-0.010521256,-0.016043797,0.04114145,-0.08079625,0.08133252,0.0018387953,-0.032285832,-0.060420025,0.04870935,0.012717911,-0.05838033,0.01634892,-0.022397185,0.013567725,0.095201224,0.056018192,-0.05697319,-0.01893497,-0.020154795,0.05116844,-0.0047046887,0.019469433,-0.1503214,0.042166065,-0.0017475886,-0.04156109,-0.010353556,0.0044926936,-0.035260763,0.04872857,0.0017908452,0.011729536,-0.015696459,-0.085732386,-0.04846457,0.021321679,0.0007701475,-0.041225396,-0.12965466,0.06892473,0.0116233155,-0.072585694,-0.079399884,0.018170014,-0.054878525,0.021172272,-0.028475458,0.016600003,-0.027224781,-0.046274763,0.06398769,-0.06679451,-0.051257893,-0.022587504,-0.0463768,0.011741176,0.022320285,-0.08435112,-0.03492821,0.0019208688,0.0610619,-0.022322686,0.19502486,-0.028018903 +3.3.2.14,"The enzyme, characterized from the bacterium Nocardioides sp. JS1661, is involved in the degradation of 2,4-dinitroanisole. Unlike other known O-demethylases, such as EC 1.14.99.15, 4-methoxybenzoate monooxygenase (O-demethylating), or EC 1.14.11.32, codeine 3-O-demethylase, it does not require oxygen or electron donors, and produces methanol rather than formaldehyde.",384,1.0,-0.08783341,0.009032662,-0.06698493,0.025325082,0.07733822,-0.07601458,-0.05361605,0.026500512,0.034026615,-0.07501115,-0.008435807,-0.03739843,-0.054716717,0.050179437,-0.06049385,0.074965596,-0.03280944,-0.030834287,0.0038904678,0.00013421407,-0.0071268314,0.07695554,-0.031194268,-0.020611027,0.057517592,0.010529978,0.034695692,-0.04311362,-0.028039558,-0.06584656,0.115044534,0.020897087,0.1300671,-0.020723457,0.09585206,0.071640864,0.027129224,-0.069820896,-0.028911762,0.090005785,-0.04356513,0.040661905,0.0017287135,-0.051422432,0.0036176352,-0.043126475,0.021154067,-0.0016476827,0.016016036,-0.06343196,-0.045334347,-0.017278418,0.018263921,-0.02726297,0.047369078,-0.07293786,-0.04992392,-0.06620664,-0.09917641,0.032199558,0.029463565,0.037955116,0.029517617,0.0048419004,0.030693319,-0.017706852,0.08056896,-0.07218509,0.04450286,-0.008839813,-0.07682081,-0.04494062,0.056698218,-0.01691848,-0.037698623,0.0131725045,-0.002727927,-0.08804972,0.1064838,-0.025808306,-0.041897647,-0.0111931525,-0.041405715,0.03349196,-0.007920884,0.0072694523,0.034322876,-0.017372463,0.04196957,0.030756565,-0.028102335,-0.00047240648,0.004569315,-0.033392858,-0.04444077,-0.0073844916,0.07838635,0.10899068,0.016783103,0.013010451,-0.032039803,0.06719732,-0.10300289,-0.043053325,-0.034281023,-0.032281525,0.11906402,0.07753067,0.053302187,0.050134674,0.036111977,-0.00029371312,0.056222126,-0.00443793,-0.026943076,0.08081755,0.055093773,-0.037622996,-0.0642504,0.074400716,-0.02319763,-0.08082032,0.038534127,-0.0063203326,-0.0050782235,0.09910718,-0.051881067,1.956953e-33,0.06195755,0.06036258,0.014804455,-0.050962634,-0.011581296,-0.035692353,-0.12130335,0.04307136,-0.02806336,-0.034678113,-0.0475226,-0.027370898,0.018577753,0.02900509,-0.005287583,-0.046956934,-0.045322258,-0.008506645,0.03942493,0.02128043,-0.019902455,-0.013810899,-0.07772009,0.071438394,0.02304718,0.05910672,0.045367993,0.027666152,0.022441177,-0.0061279004,0.010492456,-0.091169216,-0.062103562,0.016092293,0.019806629,0.037938885,-0.09054823,0.0074372846,-0.04262785,0.017644467,0.00013837304,0.03272754,-0.0057151844,-0.0927591,0.0692871,-0.019264309,-0.056801543,0.11542043,0.03429448,0.028160349,0.021498408,0.011857324,0.10525791,-0.04309869,-0.022498287,-0.005875794,-0.036227666,-0.058624003,0.108738266,0.012230385,-0.044902753,0.0010421914,-0.05552124,-0.04238583,-0.009784722,0.0037158895,-0.043589678,-0.02930722,0.008242111,0.020065408,-0.0025054896,0.021084215,0.011809471,0.070720576,0.018568415,-0.019796323,-0.019937068,0.05025297,0.09263252,-0.036996853,0.026708372,0.0007941317,0.0362603,-0.028578216,-0.0033498276,0.0056689796,-0.0049348464,0.053596325,0.0076548746,0.091422684,0.01238731,-0.12649426,-0.07531943,-0.073070526,0.021407675,-1.975817e-33,0.07323779,-0.012593639,-0.01905596,-0.0905566,-0.023638953,0.04384069,0.005539737,0.074676715,0.050906032,-0.039753813,0.08002691,-0.010851715,0.087440975,-0.07119726,0.063904844,0.02553924,-0.00830398,0.01629872,-0.056945343,0.0054856767,-0.00039674493,0.062212843,-0.03425101,-0.059564404,0.034985818,0.07052141,-0.029060896,0.023474285,0.031589475,0.008612477,0.009488982,0.034320522,-0.042775203,-0.035186913,0.010179065,0.014954985,-0.06775523,0.022273833,-0.023925772,-0.07088956,-0.04480612,0.031720743,0.03384024,0.13786969,0.033344164,0.07674463,-0.106363334,-0.04306122,0.055866376,-0.09644618,0.0030247448,-0.0067720064,-0.032201774,0.02272154,0.015781434,0.048166882,-0.008859177,-0.009630661,-0.025017714,-0.03586019,-0.009358716,-0.09911257,0.07241556,0.011531632,0.005392783,-0.011769979,-0.07341456,0.06943452,-0.020856563,-0.04452717,0.048338618,0.00053350127,0.016953971,0.023423674,-0.098996684,-0.024379374,-0.06545357,0.0061991536,-0.01937634,-0.030441007,0.004795821,-0.057991236,-0.0003887254,-0.049498893,-0.017659688,-0.04367723,0.07516906,0.055984095,-0.023679174,0.049405072,-0.07738774,0.018906519,-0.06590301,0.02579689,0.017719174,-4.191209e-08,-0.0067449845,-0.08742978,0.075635366,-0.03019364,-0.029315243,0.06668066,0.049970098,0.07208175,0.07837759,-0.020097984,0.06276118,0.12303571,-0.034852,-0.015447206,0.0057909456,-0.027520057,-0.082274646,-0.036532663,-0.02918645,-0.010859571,-0.058780488,0.011767271,-0.057352427,0.05264259,-0.0102748405,-0.018910173,0.09002208,0.009668867,0.013512209,-0.07876825,-0.020709781,0.096109316,0.062156413,-0.018110704,-0.12196547,-0.055553515,0.014047998,0.0024175523,-0.025042934,0.05923163,-0.008672914,0.0025390827,-0.14079513,-0.0073818066,0.057472184,-0.0029447335,-0.0053781806,0.016476413,-0.07064034,0.010054668,0.06391965,-0.009205769,-0.022712734,0.020098876,-0.039286945,-0.01549933,-0.008371186,-0.024607975,0.012908917,-0.018404746,0.012595547,-0.029545743,0.20127809,0.012415532 +3.4.14.13,"The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the recycling of the murein peptide. ",384,1.0,-0.110457435,-0.08439219,-0.044895206,-0.022388617,0.046168428,-0.012815487,-0.018346945,0.0633595,0.06791358,-0.047583614,0.020428475,-0.048071105,-0.015496275,0.09932341,-0.07417196,0.097104736,-0.060873862,0.039902907,0.015720159,-0.026309585,0.10165283,0.05415653,-0.031208878,0.03576844,0.028825594,-0.04356006,0.055529226,-0.025689555,0.019130157,0.031614404,-0.008785983,-0.006619648,0.011865935,-0.013900673,0.016581312,0.11663024,-0.026269507,-0.047222573,0.101631075,-0.015109137,0.017701596,0.020553386,-0.018735895,-0.06178011,-0.018087411,0.03177117,0.028592179,-0.009444586,0.03633926,0.010158895,-0.02956858,-0.019328516,-0.035133895,0.017518632,0.030609189,-0.033602133,-0.06681314,-0.08077323,0.00021914724,0.0009362694,-0.028431602,-0.02120494,0.09377026,0.01712781,0.005985074,-0.07404131,-0.015977947,-0.062130187,-0.015253769,-0.06792362,-0.030491903,-0.06801747,-0.008933249,0.01286836,0.05085209,0.013364802,-0.043343093,0.016579958,-0.051782362,0.014655267,0.052662212,0.015995808,0.025640203,0.115133904,0.04698975,-0.009280255,0.067732744,-0.02931106,-0.017670102,-0.010816714,0.043265767,-0.037097223,0.017819133,-0.05557151,-0.027685938,-0.030409317,-0.06772281,-0.01889422,0.06372309,0.041586462,-0.08896075,0.087587476,0.016479474,-0.060784537,-0.085700765,-0.066578895,0.040522113,0.06855221,0.08745754,-0.030597126,0.042181477,0.035161506,0.086501576,0.040169287,0.03789957,0.0370423,0.036213234,-0.0029344202,-0.033342674,0.03955207,-0.016826145,-0.022930369,0.034818582,0.104080595,-0.06548387,0.048638735,-0.056018934,-2.3048199e-33,0.03439948,-0.04824394,0.05684307,0.03838832,-0.040322773,-0.06763586,-0.068943344,-0.0032452627,-0.00368423,-0.092900716,-0.052793156,-0.07756124,0.016815076,0.07630691,-0.03878358,-0.06652081,0.037159715,0.017956339,0.045347735,-0.05744213,-0.0046640225,0.0627687,0.017906647,0.006541499,0.07772423,0.048759714,0.0069146594,0.023883123,0.04360811,-0.05174732,0.029408451,-0.012504211,-0.12587118,0.026368104,0.00060871843,0.016774626,0.011334485,1.6800828e-05,0.009630869,0.06710573,-0.019800138,0.027358573,0.014230209,-0.0630983,0.09550418,-0.020601055,-0.016202897,0.04915951,0.0015173908,0.046469934,0.022634897,-0.030773006,0.076309584,-0.042176317,-0.07435152,-0.012011572,0.017319486,-0.039792176,0.0040569296,0.01897923,0.0014384291,-0.00692489,-0.081985116,0.036067758,-0.02676944,0.040615056,-0.06403394,-0.012599033,0.013905818,0.099476695,-0.035956748,0.05475036,-0.011476544,0.017073091,-0.007090768,-0.02716608,-0.066736855,-0.02350303,0.020692024,0.031802144,-0.03608457,0.0345504,-0.024890615,-0.0032921121,-0.07205875,-0.010888073,0.008081765,-0.1057913,0.03035261,0.0023295775,-0.0062781824,-0.07669966,-0.09748701,0.022223223,-0.040403143,1.256451e-33,0.10764282,-0.13953254,0.032801,-0.029998539,-0.094219215,0.02891185,-0.016542034,0.056320462,-0.022300621,-0.048405472,-0.008374298,-0.032700025,0.007987293,-0.01779488,0.036366265,0.05415484,-0.04135764,0.02387052,-0.04707213,-0.03066083,0.005733248,0.08474255,0.1060193,-0.089002214,0.073781,0.0630932,-0.023838967,0.14227885,0.12692869,-0.03741536,-0.108525775,-0.018089578,-0.020882456,-0.048060417,-0.05846672,0.04416175,-0.018040834,0.035079945,0.045631632,-0.07116546,-0.00096829096,0.07020748,4.237847e-05,0.09390643,0.049338866,0.07265385,0.016951818,0.029372353,0.051957633,-0.09062266,-0.0045069386,-0.054193094,0.06487763,-0.09559021,-0.01687467,0.04901017,-0.030042278,0.020234073,-0.039896794,-0.075381555,0.009797838,-0.027078584,0.046914,0.012215867,-0.0016419981,0.12340959,0.0112097645,0.0028394947,0.023857228,-0.063626006,0.05367751,-0.012927292,0.021866,-0.0007647557,0.025918258,-0.024642907,-0.14775923,-0.02155661,0.025292741,-0.030071493,-0.08754013,-0.024709435,-0.0745485,-0.038716838,0.0069258935,-0.001011134,0.027469771,0.026730064,0.047708306,-0.029825611,-0.034660596,0.049932115,0.045342688,0.03185465,0.005271542,-2.3840823e-08,0.07996984,-0.0680627,0.041146815,-0.0025010891,0.015325598,0.022894043,0.0040862104,-0.01912397,-0.03263689,-0.033577483,-0.044613034,0.038395435,-0.06765257,0.01945408,0.012843391,0.06815417,-0.059723996,-0.05417625,0.0022249944,-0.035993334,-0.046441555,0.034037083,-0.058852855,0.1413408,-0.00036397672,-0.053102035,-0.02295899,0.090996705,-0.021888724,-0.020300223,0.002675555,0.06270241,0.021757338,-0.014034814,-0.06942284,0.01062408,-0.096970014,-0.0374168,0.023931922,0.024460293,0.07936459,0.047253206,-0.03253858,-0.016860904,-0.008605257,0.0026795778,-0.04233177,0.059068803,0.01749247,-0.012855802,0.06625689,-0.009910865,-0.02981191,0.07133012,-0.12735344,-0.014382927,0.018690228,-0.06090293,0.043917764,-0.01899122,0.022757685,-0.005571784,0.15997544,-0.028049191 +3.5.1.118,The enzyme is part of the biosynthesis pathway of ergothioneine in mycobacteria.,384,1.0,-0.04229295,0.019850502,-0.11682355,0.006938443,0.022487843,0.012211895,-0.003870782,0.093552366,0.010519552,0.01622039,-0.037830044,-0.026039453,0.026946452,0.008891696,-0.009839406,0.0615023,-0.04311967,0.007252475,0.010898677,-0.04239467,0.088042654,0.09384991,0.015368447,-0.068511076,0.061397795,-0.013671218,0.08351218,0.009657607,-0.07011638,-0.07576943,-0.030033495,-0.1293694,0.074220955,-0.031966604,0.0724475,0.092768736,-0.04630422,-0.06421997,0.10618523,0.0073974216,0.030045511,0.03183731,-0.0031243444,0.0056158975,-0.038043473,0.028396307,-0.07388105,0.039972164,0.008526503,0.0059880666,-0.050123785,-0.0011794851,-0.057597935,0.0033248535,0.06995931,0.029613052,0.0042334977,-0.03308029,-0.03133317,0.044513535,0.13336697,-0.042105246,-0.040931456,0.014842144,-0.0054352037,-0.057439193,0.04288284,-0.02134954,-0.020271175,-0.06769618,-0.07705135,-0.04480134,-0.057828333,0.06298579,-0.004926498,-0.04414285,0.02719899,0.02864338,-0.01586837,0.014411093,-0.040273182,-0.048849843,0.023788854,0.006300616,0.017146327,0.0017858992,0.07505603,0.029098043,0.003254127,0.10117531,0.06069774,-0.09585488,-0.014550522,-0.041451167,0.0025402103,0.018733189,0.023105038,-0.0032122887,0.03973969,-0.04000834,0.022863593,0.013052702,0.0055074897,-0.047251422,-0.049198307,0.03153146,-0.012546933,0.042317297,0.020978075,-0.012351834,-0.047256604,0.0128141185,0.032499988,0.02690424,-0.031645656,0.080554895,0.08742944,-0.009299767,-0.11780204,0.09257745,0.018392848,-0.012560056,0.023063565,0.061405078,-0.0655385,-0.05562472,-0.10118407,1.4261631e-34,0.051966704,0.0006419789,-0.03268586,-0.05479462,0.036092993,0.0617586,-0.061654788,-0.011052453,-0.06409927,-0.07515154,-0.055824682,-0.13283041,0.03474434,0.021449126,-0.12699507,0.047008034,-0.033726647,0.01819567,0.080242015,0.031300742,-0.013975409,-0.035443474,-0.026029749,0.00084040413,-0.05189567,0.077727616,-0.03404448,0.05480165,0.009037209,-0.008297619,0.03368717,-0.1114539,-0.062207803,0.025968663,0.06440458,-0.04936336,0.028149087,-0.037479907,0.06277774,-0.04678027,-0.008659521,0.021438332,-0.015445811,0.008804467,0.022768373,-0.045633927,-0.039990004,0.007227102,0.046397127,0.08710664,0.005949441,-0.07665004,0.11410404,-0.069619134,-0.031365078,-0.012163238,-0.0417297,0.050084233,0.0709775,0.04321704,0.038758185,0.10159194,-0.02187875,0.07772164,0.025860973,-0.005836623,-0.026101358,0.0089920685,-0.020746516,0.089307666,-0.017659273,-0.07382607,0.01450545,0.01637987,0.014011486,-0.039762404,-0.10901623,-0.037379116,-0.019543517,-0.045202795,0.021286005,0.0054243356,-0.08414672,-0.011813843,-0.010844391,0.006800816,-0.060424563,-0.067621656,0.0155980075,0.018025681,0.053609755,-0.065255575,-0.08078702,0.03957684,-0.011502031,-3.148962e-33,0.15078345,-0.10761545,0.07490647,-0.08223516,0.028313803,0.0005587226,0.06157024,0.03512585,0.011244556,0.05830391,0.0662032,-0.018218083,-0.036096245,-0.04167536,-0.01610862,-0.028513044,0.021429842,0.068806194,-0.019800229,0.004673929,-0.033439513,0.057065956,0.0018232564,-0.034776744,-0.0016166735,0.012732617,-0.072470516,0.057586025,-0.016943663,0.06919291,-0.032698505,-0.021048425,-0.072960444,-0.115251064,-0.057173442,0.050601922,-0.08207206,-0.026226103,0.04202688,-0.07665135,0.049017,0.058791157,-0.017216917,0.0034075077,0.03207514,0.023354435,-0.05546245,0.03302776,-0.031514667,-0.08333566,-0.053571656,0.034118213,0.07895739,-0.0036777821,-0.01151925,-0.007263767,0.04742288,-0.044238716,-0.003559577,0.016710436,-0.056156542,-0.028583346,-0.0004248696,0.027371785,0.052199706,0.051829237,0.008294922,0.10756084,0.09737301,0.0018379181,0.06431176,0.0018480163,-0.011778729,0.041877788,-0.08466429,-0.043335326,-0.038782313,-0.01291025,0.0125721255,0.031626806,0.038315065,0.034943037,-0.032870233,-0.09417959,-0.060286853,-0.112910785,0.024141775,0.112255335,-0.02714873,0.031345684,0.008838268,0.022934115,-0.06623597,0.05474863,0.006432394,-2.5350227e-08,0.043922067,-0.057858665,0.1268298,-0.025802927,0.040952664,-0.029178012,-2.1397285e-05,0.045674685,0.036162812,0.014371432,0.013814034,0.038439583,0.011973411,-0.04042851,0.07680411,0.019890005,-0.026756294,0.022414364,0.027895855,0.020271474,-0.008674378,-0.016768549,-0.046437863,0.01704188,0.082114436,-0.046164516,0.00078762235,0.022100525,0.032213308,-0.009850126,0.02683829,0.00032638354,-0.0073949513,-0.021520708,-0.12685765,-0.024601508,-0.05390629,-0.07720319,0.012438385,-0.07442866,0.032074675,0.02364275,-0.03650313,0.032677986,-0.048438292,0.07665063,0.026251512,-0.029360011,0.015355271,-0.041274972,-0.013324627,-0.020116283,-0.034069516,-0.03340671,-0.074851595,0.08192528,-0.009216703,-0.0077312742,-0.02824609,-0.036403134,0.0397923,0.036481574,0.15287502,-0.046934895 +4.1.1.100,"The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme isomerizes only the pro-R double bond in prephenate. ",384,1.0,-0.06577004,-0.04439395,-0.090547524,-0.007058139,0.04633898,0.021021398,-0.06980483,0.05470963,0.037947472,0.004642681,0.018458271,-0.021407584,0.029570425,0.055589523,-0.07874655,0.026766827,-0.10973575,0.00028987488,-0.0035599517,-0.010215482,0.025956782,0.07218435,-0.017596127,0.028676793,0.09579167,0.013431249,0.078274965,-0.017545689,0.04458816,-0.030968832,0.029158702,-0.060792986,0.098799534,-0.13279328,0.054747127,0.0018662218,-0.038531493,-0.002039532,0.2003715,0.022319362,-0.034929242,0.036064204,-0.0066222227,-0.081869304,-0.0018171057,0.030988907,0.0368967,0.01913595,0.008118869,0.037780873,-0.04159197,-0.018361973,-0.0314803,0.0076977843,0.005574463,-0.010372001,-0.11086416,-0.032141317,5.5568824e-05,0.005187942,0.02465616,1.9861869e-05,0.06027859,0.022772528,-0.05827787,-0.0032829046,-0.02075026,-0.04277708,0.0559046,-0.043899417,-0.09629998,-0.04836947,-0.0059531294,0.049426634,0.07079206,0.0018579179,0.02236077,0.048535418,-0.015935771,-0.038473066,0.05542859,-0.050604194,-0.0072817625,0.12679002,0.038541205,-0.0014523949,0.06311405,-0.01959301,0.05875486,-0.060357884,0.026996855,-0.010547672,-0.011674099,-0.09168096,-0.06686613,0.007036411,-0.08710189,0.03604626,-0.0056701177,-0.0004982606,-0.014431584,0.068391,-0.03603328,-0.059809845,-0.046475634,-0.061754227,0.042507965,0.080143064,0.045292165,-0.019235296,0.09472141,0.032438748,0.03490348,-0.050995983,-0.07422483,0.047163624,0.04203021,-0.037144646,-0.018710436,-0.06541423,0.03842841,0.0063361386,0.022477308,0.04373569,0.008573988,0.028974984,-0.056273844,3.1027225e-33,0.058793712,0.06350307,0.0068788505,-0.012075123,-0.031417914,-0.06886725,-0.06610919,0.011734188,-0.046618722,-0.014776714,-0.07373219,-0.08100325,0.038912255,0.07036556,0.05918239,0.018409202,0.05629356,-0.00053931377,0.049945746,-0.010937016,-0.036289755,0.06933263,-0.016088573,0.054000992,0.075613245,0.06590223,0.08760049,0.014580901,0.072306745,-0.020872323,0.024204219,-0.01821761,-0.086025864,0.03281472,0.049021333,-0.052962862,-0.0673942,-0.010872928,0.026555581,0.10567758,0.035631206,0.06404224,0.0026494921,-0.024274802,0.060938627,-0.030959116,-0.017852144,0.07752015,0.055551577,0.04251436,0.028744526,0.017977132,0.07735821,0.01466172,-0.036426622,0.0371948,0.012393454,0.045854706,0.0130724,0.048686527,-0.011594788,0.014147681,-0.0440484,0.028438032,-0.033737168,0.06527713,-0.011722325,-0.021986928,0.025517024,-0.011773069,-0.08395096,0.008133536,0.009125495,0.05704608,-0.055888504,-0.028554589,-0.045395765,-0.032414317,0.07688987,-0.015934762,-0.034980226,0.022617377,-0.019531881,-0.0098391,-0.04704363,-0.09115757,-0.015760606,-0.058071095,0.0007901304,0.040628087,-0.01609738,-0.04260101,-0.060137346,0.0630959,-0.007291412,-3.5273298e-33,0.0883314,-0.12646692,0.023427771,-0.098004825,-0.12758051,-0.005975403,-0.00013506829,-0.062305648,0.021242056,-0.010242667,0.01674212,-0.028393798,0.031842835,-0.0059775417,-0.025171394,0.0118400585,0.05038348,0.05861422,-0.02287068,-0.01418395,0.028802581,0.08247498,0.09596351,-0.0852081,0.05312832,0.039840925,0.018880524,0.105679624,0.05218514,0.03914334,-0.024629163,0.00091477484,-0.01281177,-0.09422992,-0.11672377,0.09385964,0.012384827,-0.02227444,0.036877144,-0.06620625,-0.011338815,0.002483155,-0.027153138,0.048352752,0.060239617,-0.013365172,-0.057523962,-0.031716056,-0.0039058689,-0.12698738,-0.04659709,-0.004388605,0.095381185,-0.032045268,-0.007914198,-0.029131176,-0.06863931,-0.0023121685,0.038141742,-0.07296503,0.019482175,-0.08102349,0.056146573,0.017574044,0.015894955,0.0824056,-0.014817177,0.00018410273,0.029806837,-0.09965272,0.05622007,-0.050508503,0.031372286,0.06188551,-0.050943185,0.010489921,-0.039595127,-0.08136341,0.010918584,-0.03866023,-0.057321113,-0.040686954,-0.049764883,-0.017602438,-0.05603027,0.0009722731,-0.054300588,0.09068762,0.015348874,-0.0007755484,-0.022692883,0.024303956,0.018882856,0.06270632,0.06388834,-3.694064e-08,0.0709431,-0.066607215,-0.0066345,-0.020286158,-0.035118386,0.06602607,-0.02779506,-0.09090362,-0.036566816,-0.05942747,-0.04963456,0.042797666,-0.0699314,-0.028362893,-0.006435187,0.05857843,-0.08424159,0.018741371,-0.037022468,0.0495727,-0.022469096,0.021739919,-0.10403092,0.026705483,0.0253197,-0.07992116,0.008277032,-0.05275246,-0.03717222,-0.0074754586,-0.0023072222,0.027233038,0.022282213,-0.033557966,-0.029187234,-0.0046172696,-0.05772034,0.0562548,0.018944535,0.02124019,0.0783832,0.008771294,-0.14324363,0.011695801,-0.008661419,0.031666897,-0.01674633,0.06074639,-0.03485407,-0.032422077,0.031465866,-0.015101446,0.01762767,-0.017016893,-0.121075235,0.04745813,-0.008386639,-0.015505927,0.003881047,-0.01624654,-0.019961461,0.017334716,0.14239669,-0.017698778 +4.1.99.21,"The enzyme catalyses the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran. Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea.",384,0.99999994,-0.056279734,0.01458984,-0.090102896,0.00076378754,0.03948283,0.017633032,-0.063893564,0.0028621494,0.029793741,0.012921307,-0.020247746,-0.051775537,-0.053204097,-0.019114638,-0.05888,0.035214495,-0.07479185,-0.005822353,0.030154279,-0.045183506,0.13436563,0.09836762,-0.014093014,0.0071294066,-0.009510969,0.009094337,0.029261656,-0.016376425,0.0053297575,0.0102145625,0.02771734,-0.010454098,0.033173077,-0.052158725,0.032182056,0.10587598,0.04945549,-0.024779018,0.06236467,0.010968599,0.04237553,-0.01202916,0.064892195,-0.012686507,-0.015983447,-0.031346846,0.008587775,0.018262375,0.018793184,-0.12395009,-0.114504635,-0.06674366,-0.076048926,-0.00464566,0.05360552,0.03961398,-0.01278182,-0.013400275,0.0039606486,-0.031262472,0.06982828,0.023915218,-0.047773514,0.0005668391,0.044320546,-0.07677087,0.030921254,-0.088295944,0.07950625,0.017242176,-0.036861468,0.014745342,-0.0049069948,-0.15019394,-0.04401423,-0.025032133,0.0068723005,-0.039584372,0.031815853,-0.03766237,0.07496017,0.03265037,0.009084297,-0.010976077,-0.0018793354,-0.03273912,-0.012817156,-0.021037064,0.05467664,0.012905821,-0.038336333,-0.025714684,0.06334914,-0.042775583,-0.11479073,-0.0016229597,0.08885606,0.046107914,0.044334367,0.06372518,-0.00931314,0.008548652,-0.059572447,-0.08424366,-0.10409998,-0.005467627,0.0009554547,0.10312078,0.06319203,0.07439468,-0.01008157,0.02044715,-0.0006048286,0.080044426,-0.037183188,0.12832783,-0.014232439,-0.11144136,-0.005919891,-0.03061836,0.0056377635,-0.06449473,0.06083049,-0.013262452,-0.07162522,0.009159708,-0.08146429,2.30591e-33,0.12713312,0.008828737,-0.0036791032,-0.05039626,-0.00085239817,-0.057717975,-0.07213203,-0.028494379,-0.0029648447,-0.011124441,-0.050028723,-0.085489824,0.047194075,0.024091536,-0.08288258,-0.08653284,-0.027799105,0.0019395,0.024846544,0.06323958,-0.0394196,0.0607553,-0.053129673,0.006380257,-0.0036607154,0.005169495,-0.053186487,0.018643491,0.046150234,0.022715304,0.042700786,-0.056751437,-0.09849716,0.020217713,0.077399895,-0.00950081,-0.098456375,-0.045526624,0.011723814,0.0014555298,0.04152813,-0.01251356,0.020455236,-0.015947748,0.05036188,0.058294237,-0.022240577,0.11953686,0.03135772,0.061530255,-0.0146630155,0.026041957,0.07615013,-0.027333934,-0.06006436,-0.0009769092,0.02144625,-0.0675373,0.026104474,0.0470387,-0.058724895,-0.005381981,-0.0059804893,0.049442537,-0.036913447,-0.01318637,0.0040006684,-0.045845546,0.10481712,0.08266467,-0.022364698,0.028366646,0.011532316,0.08539059,0.033427626,-0.039760537,0.03072275,-0.003549038,-0.00016872348,0.026278224,0.05355322,0.02497184,-0.0046187015,-0.085689336,-0.019824244,0.06961766,-0.0680316,-0.06450016,-0.0011568557,0.038291734,-0.046957623,-0.094422385,-0.011911968,0.03064721,0.01581703,-3.5580807e-33,0.06767525,-0.054684237,0.030621054,-0.122534,-0.108655706,0.03487817,0.030444017,-0.05249807,0.0088768145,-0.00944747,0.08006243,-0.01971346,0.100562945,0.011647129,0.043482352,-0.016654275,0.023319827,0.052249607,0.023936832,0.014812127,0.06943446,0.027409008,-0.08073902,-0.041710854,0.048051324,-0.007999032,-0.0096293725,0.07983045,-0.0026776963,0.029133338,-0.020260243,-0.066449136,-0.060539655,-0.049479373,-0.100710616,0.038823035,-0.10011244,-0.022704447,-0.018509017,0.01667175,0.01277621,0.07458567,0.015284251,0.052109007,0.010098068,0.055898204,-0.09423284,-0.018382221,0.020796895,-0.059308317,0.023550676,-0.019473806,-0.0010352652,-0.037285578,0.023101676,0.07699774,-0.009751215,0.07349007,0.013219771,-0.046767812,-0.027579885,-0.0730886,0.07982545,-0.051775686,0.07316163,0.05780976,0.0028702717,0.026439894,0.044037934,-0.013167116,0.022963539,0.08139681,0.03455903,0.055153646,-0.043304514,-0.069706716,-0.11197116,-0.03361874,-0.015798818,0.012662585,0.054084297,0.025301779,0.037761085,-0.08617397,-0.025729448,-0.047137268,0.10524225,0.04818202,-0.03413858,0.055258274,-0.020357078,0.030402834,-0.030782541,0.0394041,0.05115199,-3.527269e-08,-0.010236874,-0.074983664,0.08089057,-0.037925154,0.008346483,0.08109721,0.053416263,0.003745617,0.041725516,-0.038185954,-0.008663726,0.05353109,0.059469093,0.026049316,-0.021727052,0.00963697,-0.031444717,-0.038833734,-0.040670045,-0.035499692,-0.0260392,-0.006485191,-0.0256277,0.041160196,0.04017687,-0.047501802,0.040750854,0.1100843,-0.027201101,-0.036389507,-0.027191726,0.039224256,0.026952054,-0.05612107,-0.10296178,0.0067527937,-0.04962565,-0.026779389,-0.016416837,-0.020916088,0.02606367,0.046811894,-0.018933225,0.07749455,-0.0055174115,-0.020010008,-0.04404483,0.08536652,-0.04806771,0.013560929,0.013193628,-0.012619742,-0.00757409,-0.06056738,-0.056404382,-0.06405389,-0.019675821,-0.011484562,-0.094889745,0.032061543,0.061120443,0.020849546,0.13554747,-0.032477193 +4.2.1.155,"The enzyme is involved in the degradation of 3-(dimethylsulfonio)propanoate, an osmolyte produced by marine phytoplankton. Isolated from the bacterium Ruegeria pomeroyi.",384,1.0,-0.10291422,0.025797773,-0.07996028,0.004944184,0.04492736,-0.0039577484,-0.04529063,0.0178724,0.014006129,-0.016037177,-0.021015957,-0.03168993,-0.07766534,0.0052843797,-0.050971422,0.06654106,-0.064664796,0.03185309,-0.037302785,0.070238546,0.09391019,0.045194216,-0.068355925,0.033746015,0.05479683,0.02518078,0.029698806,0.05298036,-0.030233892,0.027651796,-0.025005806,0.0038230282,0.091483235,-0.077969044,0.13361147,0.07146345,0.005483374,-0.11268755,-0.0015309546,0.044397917,0.039308924,0.00598174,-0.029185936,-0.009320721,0.014391742,-0.026728243,0.037391853,0.026363721,0.016829854,-0.0672467,-0.09549068,-0.055911288,-0.08845145,-0.011390009,0.0215426,-0.024214678,0.015522621,0.018625522,-0.0013336411,-0.024302274,0.08888537,0.013371735,-0.013013481,-0.058860354,-0.011374224,-0.054327633,0.05130097,-0.06289212,0.057438433,-0.01825698,-0.05564666,-0.02307088,0.034924258,0.055577938,-0.021731798,-0.013094903,0.0030352331,-0.04953969,0.022570504,-0.03083885,0.013063182,-0.048487585,-0.03745058,0.03283762,-0.05530808,-0.020903263,0.005964123,-0.0023893188,0.06357777,0.050598353,0.019090366,0.016364086,-0.013861306,-0.1006415,-0.050562125,0.035872076,-0.006101638,0.020501282,0.05380205,0.022662101,-0.031631354,0.037124917,-0.010410094,-0.14565179,0.026901681,0.038502164,0.019092478,0.10128433,0.011987373,0.068932734,-0.017774671,0.049066648,0.02521764,0.058051776,-0.023978697,0.0764728,-0.0014274252,-0.07902122,-0.06558793,0.026384186,-0.034523286,-0.05018624,0.035321888,0.04891337,-0.010141169,0.01659334,-0.020752711,1.5142229e-33,0.09607076,-0.016170029,0.025152463,-0.060334004,0.024716595,-0.055315822,-0.04615949,-0.065959714,-0.007919156,-0.078683965,-0.04024854,-0.06563985,-0.04527493,0.033705395,0.0065103318,0.0009803519,0.029632557,0.04321104,0.009893356,-0.012649971,0.059795998,0.01601384,-0.041482177,-0.06825059,0.021150954,0.039779156,0.0017766241,-0.030924944,0.056702644,-0.00802945,0.11482346,-0.10898526,-0.084683426,-0.04944061,0.13051264,-0.03075646,-0.075361766,-0.051852565,-0.029560544,0.042367883,-0.04356627,0.010336195,0.012261838,0.029787498,0.01558779,-0.015789831,-0.0027226226,0.14973897,0.075580105,-0.036644068,0.014588297,-0.044755876,0.027130688,0.0066521247,-0.07114489,0.041109655,0.06353219,-0.06914354,0.06541253,-0.020681506,-0.018341193,0.06603318,0.006590173,0.05667684,0.059080284,0.032925684,-0.04054271,0.011076267,0.06809311,0.004600999,-0.055786412,-0.06174999,0.008949796,0.011072723,-0.053129815,-0.063678876,0.027292302,-0.013390335,-0.053316806,0.003674774,-0.0033453812,-0.054112975,0.0058847414,-0.013528247,-0.121561944,0.05153319,-0.019892816,-0.03446,0.020855326,0.08965387,0.028771274,-0.07577181,-0.09106264,-0.02768488,-0.07396816,-2.4534137e-33,0.09151521,-0.046391807,0.031988725,-0.045692213,-0.09364107,0.022408843,-0.09745714,0.0462054,-0.018506238,-0.061192993,-0.0066693784,-0.033019457,0.10522602,-0.035986293,-0.015997209,0.08107261,0.061052807,0.047549155,-0.03807036,-0.030439248,-0.0047891135,-0.0058304095,-0.01116841,0.039786555,-0.03086838,-0.042436596,-0.024894003,0.023038657,-0.016779179,0.05794072,-0.0005971897,0.009351301,-0.018430198,-0.089222044,-0.042759944,0.050294023,-0.04799326,-0.00068969827,0.061807785,0.02532071,0.026283745,-0.019625641,0.013215918,0.053459723,0.012795755,0.034327045,-0.01957801,0.0061566075,0.020380286,-0.02086882,0.05041774,0.0140001,0.039589774,-0.0024832666,0.06933013,0.05122078,-0.030478576,-0.0119622545,-0.033315428,-0.05143091,0.0435833,-0.11030644,0.027386848,0.0139950365,0.047035348,0.10418721,-0.01557188,0.040510833,0.013675641,0.0049027777,0.06495775,0.04588846,0.007056099,0.005611868,-0.06206614,-0.037981026,-0.10951418,0.023621963,-0.055258144,0.053516816,0.06682328,-0.0012304325,0.01356205,-0.07321377,-0.051515568,-0.06425082,0.11403165,0.12829249,-0.029942779,0.049813017,-0.007047985,-0.028135806,-0.111769654,0.08781759,0.019171555,-3.018287e-08,0.013089088,-0.02448939,0.06167323,0.04882695,-0.030682787,-0.0015295527,0.09533786,0.06204828,0.043297358,9.842173e-05,-0.03844546,0.010591461,-0.027923413,-0.08923073,0.07103545,0.01796174,-0.016525647,-0.006173126,-0.032699786,0.013482779,-0.01477705,-0.05016983,-0.061739102,0.018105391,0.05307235,0.039299738,0.06475887,0.039217092,-0.043196853,0.035241734,0.04914221,0.012236371,-0.07200167,-0.019487496,-0.06984039,0.033280104,-0.014077902,-0.047156647,-0.05007199,0.04363471,-0.06076448,0.063113734,-0.07566307,0.036427002,-0.021327674,0.053857993,0.024901843,0.06722182,-0.04676053,-0.033345204,0.11159378,-0.010790258,-0.017585825,-0.036453813,-0.102452055,0.06315601,0.04838737,0.009651361,-0.10004029,0.051981132,0.0292492,-0.012393416,0.15627529,-0.0042799185 +4.2.3.152,"The enzyme is highly specific for alpha-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.155, 2-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.",384,1.0,-0.08660858,-0.006528717,-0.1187767,-0.004289486,0.050630018,0.04249622,-0.05031744,0.08506139,0.03368768,0.054403845,-0.016458144,-0.024973797,-0.03699708,0.0062345886,-0.09535107,0.0034553686,-0.03605814,-0.005939298,0.044664487,-0.07272744,0.051194854,0.050138485,0.00024666838,0.023869507,0.085412614,0.0016346588,0.048814505,0.015202181,-0.07191582,-0.056924116,0.008606945,-0.0618897,0.116418324,-0.033031452,0.07666247,0.116857804,-0.035852067,-0.06922629,0.028106153,0.077630915,0.03352064,-0.02028494,-0.02762963,0.0035819954,-0.0749334,-0.09566528,-0.033531535,0.028966462,0.07739166,0.044779446,-0.054103874,-0.053297356,-0.025721237,0.013424632,0.025387628,-0.038331706,-0.07454432,-0.0007073014,-0.026006911,0.010962408,0.066376634,0.008594483,0.018941252,0.016531384,-0.038856708,-0.053535264,-0.005295516,-0.03907515,-0.0077445838,-0.051286448,-0.031304568,-0.0027071682,0.029003037,0.04594948,-0.008154317,0.02250384,-0.0130556375,-0.075389564,-0.005215047,-0.08061909,0.06359173,0.024703171,0.06954515,0.05473351,0.04858676,0.035514776,0.07250111,0.020085005,0.0651777,0.03009471,0.09608076,-0.009100811,-0.038370155,-0.030237878,-0.0342499,0.044360694,-0.009163321,-0.022244686,-0.025846688,0.015518192,-0.009986624,0.06994461,-0.05333686,-0.069106795,-0.021810867,0.060995758,-0.00074413355,0.075184666,-0.0004910708,-0.0060619256,-0.009181009,0.015452116,0.034564015,0.01985294,-0.08035709,0.12275455,0.021285323,-0.022776628,-0.065962784,-0.01212492,0.033145946,-0.016493816,0.07541437,0.061568987,-0.025218995,0.043916978,-0.06453374,2.7927562e-33,0.10054303,0.08852472,-0.01971712,-0.024529167,0.0003455666,0.02162359,-0.03637986,0.05914367,-0.053935204,-0.068799436,-0.083663985,-0.07540706,0.08213282,0.04859003,0.012788732,-0.01672736,-0.013414868,-0.019837867,0.073959276,0.015888928,0.038210977,-0.0022220197,-0.06725763,0.09301732,-0.0105021885,0.07152341,-0.02714,0.070891716,0.07306319,-0.0015705933,-0.066229664,-0.021607378,0.009221418,-0.014010862,0.10050625,-0.024527444,-0.055534467,-0.043254722,0.03688585,0.066867135,-0.006950941,-0.008199728,0.02603014,-0.048554074,0.0687524,-0.062332813,-0.06318852,0.07201006,0.029134661,0.058515355,0.049516458,0.006965434,0.103405185,-0.019703783,-0.053784262,0.02435906,-0.071675554,-0.0059031867,0.07073513,0.0006143648,0.058872778,0.00047900033,-0.0127538,-0.052128594,0.026093518,-0.029221442,-0.047962632,-0.07465946,-0.07720989,-0.009971713,-0.034499623,-0.07222879,0.010313481,0.04044494,0.047635317,-0.03267947,-0.06344508,-0.008579914,0.04451947,-0.053089112,-0.044463955,0.02217194,-0.038320575,-0.05712579,0.03751607,-0.020990288,-0.043611754,-0.029967394,-0.021851981,0.031045225,-0.03205374,-0.050368592,-0.1123749,0.01966961,0.019984929,-3.0952676e-33,0.07084927,-0.064910255,0.021653982,-0.025032993,-0.0698763,0.020011263,0.009322579,-0.0011775192,0.030480146,-0.054507576,0.09714175,-0.034455605,0.015005387,-0.04820066,-0.0048413957,0.053984918,-0.056374744,0.0664982,-0.05415706,-0.011091994,0.007517269,0.08956916,0.02457086,0.08495459,0.07344084,-0.008961583,0.010076819,0.07371165,0.023457944,0.1072379,-0.023794867,-0.04763789,-0.08059541,-0.004284455,-0.07886352,0.11315457,-0.083878696,-0.059005514,0.05062009,0.06398559,0.032331876,-0.007698128,0.0056586945,-0.030248635,0.05950022,0.027030833,-0.03965237,0.08268111,0.026677791,-0.088173546,0.005089638,0.017859694,-0.016117904,0.044268854,0.0129722105,0.034076475,0.019459764,0.021710128,-0.0036380515,-0.06038163,0.026665386,-0.0404259,0.057158478,0.02060946,0.06352222,0.07141149,-0.0062165535,0.08432202,0.047123842,-0.03966918,0.05276894,-0.022122527,0.010195149,0.0637274,-0.0013125476,-0.11452919,-0.08751851,-0.04332254,-0.025614219,-0.024137262,-0.011573205,0.010719778,0.0144414045,-0.044913337,-0.069129646,0.009541026,0.07011489,0.029031755,0.0003659555,0.04368816,-0.009042233,0.01792323,-0.027614549,0.042106617,0.0785654,-4.8649547e-08,0.08884343,-0.06610689,0.057677362,-0.07854882,0.016575204,-0.050279204,0.010276587,-0.067591414,0.026275808,-0.05704139,-0.02256464,0.11692122,0.01645972,0.04875377,0.008499615,0.013488474,-0.0050048,0.09978405,-0.031172989,0.003656002,-0.020992588,-0.048741765,-0.0719595,0.03724576,0.02386153,-0.079584844,0.004194995,-0.016635355,0.025760189,-0.01756267,0.047071543,-0.011114891,0.035814125,-0.058419764,-0.086039245,0.06414314,-0.05388373,-0.050134167,0.034454744,-0.0356376,-0.018326318,-0.06067163,-0.024824768,0.01759905,-0.034856148,-0.0037696725,0.04602472,0.024864892,-0.02787216,0.020515217,0.007497648,-0.028906427,0.005627903,-0.115195155,-0.049294103,-0.056224074,-0.037320092,-0.04292983,0.04989789,-0.105137974,-0.05562674,-0.020169195,0.18836051,-0.04741903 +4.4.1.29,"The enzyme, found in cyanobacteria and red algae, catalyses the attachment of phycobilin chromophores to cysteine 84 of several phycobiliproteins (the numbering used here corresponds to the enzyme from Anabaena, in other organisms the number may vary slightly). It can attach phycocyanobilin to the beta subunits of C-phycocyanin and phycoerythrocyanin and to both subunits of allophycocyanin. In addition, it can attach phycoerythrobilin to both subunits of C-phycoerythrin.",384,1.0,-0.12403246,-0.04800774,-0.10750817,0.035577185,0.053355258,0.06848608,-0.031880822,-0.023945088,-0.014850222,0.005021018,0.055071775,-0.05077109,-0.086359315,0.10435346,-0.09531455,0.0722436,-0.114964,0.034014948,-0.047277916,0.061005354,0.02104054,0.035665274,-0.01956648,0.055164304,0.059466254,-0.073854856,-0.01970366,-0.0113291275,-0.06656988,0.012953404,-0.011153866,-0.06457614,0.033261225,0.000664067,0.11156711,0.052707627,-0.030305862,-0.12929569,0.07726822,-0.037402377,0.042239085,0.013578511,-0.0029519766,0.024378596,-0.044247746,0.017896986,0.004246868,0.022822306,0.039829165,0.008710229,-0.024785014,-0.02440776,-0.074016236,0.017257836,0.022972915,0.05126522,-0.0870895,-0.024700692,0.053897116,0.015181771,0.048178643,0.02147646,-0.029655242,0.06444928,-0.008315475,-0.0657621,-0.009856762,-0.06795923,0.007556708,-0.04331948,-0.025431922,-0.08103296,0.017727312,0.013371766,0.020413257,0.07065362,0.056690745,0.020968884,-0.052603714,-0.053129204,0.012259751,-0.008033481,0.023884276,0.059510995,0.05058697,-0.029627686,0.029429022,0.009461785,0.0020410619,0.031243253,0.08654056,0.05151859,0.040363207,-0.090737425,-0.09619552,0.024816316,0.031058708,-0.0068972665,0.008482402,0.0038410425,0.003961928,-0.006395479,0.09499496,-0.09184547,-0.013820542,0.02690427,-0.021472482,0.019621294,0.056413874,-0.016865727,-0.017764932,0.009965834,0.028967366,-0.010651679,0.02997677,0.06187598,-0.054444157,-0.004891126,-0.021605164,0.03304429,-0.020859987,-0.07020637,0.0575672,0.05804781,-0.028937452,0.008953108,-0.09896499,6.3717054e-33,0.084590524,-0.006649243,0.038068566,-0.03466686,0.038043134,-0.021031946,-0.051749784,0.055060264,-0.0063788476,-0.09015745,-0.061679807,-0.001004912,0.044658214,0.0013714383,-0.09575431,-0.023496477,-0.039921988,-0.03970904,0.052978784,0.07726785,0.0035565987,0.02938818,-0.044619117,0.026152907,0.021279713,0.04543207,-0.0743642,0.046581555,0.04093113,0.022038002,0.039193586,-0.10364265,-0.08823666,0.0045594187,0.029402008,0.0017448721,-0.01502921,-0.079829834,0.007819049,0.02738538,-0.034758158,-0.047816135,-0.031352792,0.040315703,0.006560131,0.0025563363,-0.0334985,0.052764263,-0.016282402,0.042860195,0.00033780164,-0.08017487,0.052088447,-0.008475588,-0.068632506,0.007257713,-0.02069944,-0.02344229,0.04397797,-0.011224804,0.012544887,0.021298373,-0.016302194,-0.03784233,0.035923388,0.03471399,-0.026389461,-0.03832946,0.019764123,-0.033237096,-0.06625447,-0.026441185,0.036602564,0.0074023707,0.028578425,-0.028158573,-0.013469978,-0.04264867,-0.006613681,0.016159631,-0.050427455,-0.0010962713,0.0183107,-0.047620825,0.0017205045,0.007246042,-0.012223871,-0.043219622,-0.013035282,0.0031433052,0.03855994,-0.0981774,-0.022545531,-0.015798092,0.007390745,-7.272688e-33,0.10530728,-0.12792914,0.006460981,-0.033512328,-0.03475196,-0.003626251,0.012407729,-0.05957602,-0.06036836,-0.05743653,0.086132444,-0.036577515,0.024671653,0.022472367,0.00061665085,0.09193505,-0.022039717,0.08722248,0.0045601707,0.046051186,-0.041815665,-0.010139661,0.06995695,0.029058112,0.054022256,0.032975014,-0.055582948,-0.023050811,0.032057036,0.0697397,-0.10639195,0.0116305705,-0.04465623,-0.049570482,-0.03340234,0.072829746,-0.069329634,-0.041410852,0.06691284,0.030498441,0.04983368,-0.0375408,-0.05072821,0.027365364,0.024401024,0.07248446,-0.0032160254,0.059188787,-0.06009172,0.01843546,0.025587011,0.09552667,-0.015487861,0.05775327,7.6882985e-05,0.16068546,0.11014792,0.014027952,-0.009543619,-0.02590504,-0.07710722,-0.053348955,0.008565354,0.035683054,0.052505422,0.10641231,-0.0023194128,0.119301744,0.00455438,-0.052986257,0.024436833,0.0064523225,0.09147594,-0.0019552447,-0.06613207,0.01799899,-0.01664099,-0.057476267,-0.05035194,0.034919675,0.012054461,-0.0022930782,0.011990824,-0.030407961,-0.032474972,-0.07715631,0.11585745,0.03576841,-0.05156428,-0.025942625,0.011039743,0.060876496,-0.005951367,0.059579726,0.11386933,-3.9725688e-08,0.06113496,-0.027622685,0.039917324,-0.11904677,0.096639365,0.01328429,-0.030097382,0.0033362291,-0.026004357,-0.014169697,-0.0029834332,0.028207138,-0.06479055,0.0035874194,0.034624007,0.05212654,-0.05451048,-0.0418302,-0.01273249,0.027470686,-0.07276474,-0.00027070584,-0.08480385,0.06287105,-0.060602102,-0.028075483,-0.008010718,0.0435935,-0.05678502,0.012109616,0.038540807,0.00046896908,-0.102256805,-0.033137146,-0.028687522,0.06580784,-0.03044263,-0.110637486,-0.038117196,0.018084034,-0.057549827,-0.018779516,-0.060861774,0.02481461,0.034234073,0.01628198,0.035738003,0.011284957,-0.005764131,0.02903849,-0.012385801,-0.040722482,-0.06201654,-0.06797872,-0.059502937,-0.014779671,0.059266098,-0.005936709,-0.13380916,0.07460867,-0.080893,0.07241388,0.16425794,-0.0458973 +4.4.1.30,"The enzyme, found in cyanobacteria and red algae, catalyses the attachment of the phycobilin chromophore phycocyanobilin to cysteine 155 of the beta subunits of the phycobiliproteins C-phycocyanin and phycoerythrocyanin. The numbering used here corresponds to the enzyme from Anabaena, and could vary slightly in other organisms. 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PCC 7120 and Mastigocladus laminosus, catalyses the covalent attachment of the phycobilin chromophore phycocyanobilin to cysteine 84 of the beta subunit of the phycobiliprotein phycoerythrocyanin and its isomerization to phycoviolobilin.",384,1.0,-0.12026384,-0.015423884,-0.09185028,0.03509371,0.038016465,0.042261254,-0.03788959,-0.014902657,-0.028837647,0.035126228,0.048952546,-0.05003985,-0.07354751,0.10611896,-0.08956832,0.028056169,-0.08419713,0.03731028,-0.0016750518,0.09838495,0.028473035,0.06396392,-0.035328403,0.07625999,0.041695263,-0.024000669,-0.017015686,-0.016244289,-0.042665444,0.016723659,-0.023114888,-0.09008872,0.09306585,-0.02422302,0.105807036,0.009670626,0.009202639,-0.13267289,0.07446378,-0.011969058,0.08882782,0.026302133,0.014659212,0.033162616,-0.045218848,0.028284524,0.017176481,-0.02194495,0.072262876,-0.026428774,-0.031696055,-0.049036086,-0.08759165,0.016936818,-0.018819353,0.07897113,-0.056377564,-0.02405348,0.04302417,0.039938796,0.037086826,-0.005876862,-0.004506793,0.05960016,0.012049652,-0.08837753,-0.02748006,-0.034272525,0.027326033,-0.042664804,0.0034007386,-0.056377582,-0.009228217,0.018238889,-0.00091802515,0.083267845,0.042445764,0.04697855,-0.02433883,-0.033963297,0.012890325,-0.052609622,-0.014981934,0.053438015,0.027088484,-0.032852657,-0.018029287,0.027889665,0.013845362,0.020043945,0.088246934,0.0694756,0.032760452,-0.112610064,-0.09406143,0.007448537,0.075115286,0.036386263,-0.0128533,0.02680977,-0.020895991,-0.005332493,0.06945535,-0.10733749,-0.00038435176,0.010716986,-0.0111013735,-0.016924025,0.037649736,-0.003235061,-0.040280994,0.010433983,-0.0035058267,-0.02854591,0.014000936,0.0046323244,-0.021129828,0.00583295,0.0070181894,0.04154426,-0.0052526304,-0.06670574,0.07150463,0.02729804,-0.03770822,0.009256173,-0.06164762,7.1907e-33,0.08373602,-0.02006208,0.043341834,-0.056945547,0.0077496995,-0.025986174,-0.030490043,0.020706007,-0.011227985,-0.08075674,-0.051857077,-0.012881624,0.066134445,-0.0061748293,-0.083457924,0.018622871,-0.047352366,-0.032247704,0.078558624,0.036495328,0.0050315196,0.03867844,0.0015049572,0.053652633,0.03667615,0.00666684,-0.10119776,-0.020619731,0.028716208,0.028583227,0.0046114745,-0.100060046,-0.08143149,-0.030974818,0.038184445,-0.014494275,-0.037742127,-0.112086564,0.012105936,0.033351995,-0.06727455,-0.091041155,-0.019547045,0.011550215,-0.034480534,0.046079133,-0.021633368,0.041234322,-0.032192394,0.04156406,0.00763253,-0.09049364,0.002961482,0.011620322,-0.07582998,-0.0076738526,0.011373237,-0.037409957,0.025893461,-0.054116294,0.019897792,0.028501846,-0.007878764,-0.025041109,0.037200533,0.0011520253,-0.055090155,-0.016099283,0.003549391,-0.0025244532,-0.031588037,-0.047266148,-0.004197572,-0.0064911013,0.027171927,-0.013065685,-0.0349829,-0.052976836,0.045007247,0.029347526,-0.04613935,0.008110234,-0.022313364,-0.03777927,-0.0123566445,0.017382069,0.021410417,0.00846507,0.0022393935,0.016667543,0.0019198995,-0.05364384,0.020450091,0.02036315,0.019356504,-8.393758e-33,0.10501146,-0.09255681,0.025393674,-0.019525085,-0.039678507,-0.024251906,-0.024457611,-0.0361411,-0.06794385,-0.04775681,0.07322695,-0.0907478,0.02149799,0.035218835,0.024244811,0.076291345,-0.034806047,0.07893884,-0.0033635534,0.008517999,-0.015563794,-0.041882902,0.057689905,0.02180745,0.06703957,-0.033719387,-0.059624024,-0.004284161,0.07805633,0.0641767,-0.11398635,0.050967522,-0.045612227,-0.02333422,-0.032022778,0.08162784,-0.032158345,-0.037167694,0.11877906,-0.0030341598,0.035917107,-0.015146446,-0.045489654,0.024268102,0.040557217,0.0506117,0.030837346,0.0691662,-0.0057019037,0.018867603,0.023205856,0.084903605,-0.036645543,0.0554417,-0.024043176,0.1474322,0.06993388,0.035302795,0.01053353,-0.047867052,-0.020002907,-0.11025397,-0.039836526,0.018948844,0.065477274,0.10386349,0.013761197,0.108711466,-0.014446801,-0.076068744,0.004879478,0.0032403194,0.104692094,0.0071965475,-0.044407267,-0.01234765,-0.022818651,-0.07364973,-0.07507509,0.034928102,0.04433955,-0.021472745,-0.004535542,-0.026155958,-0.029340034,-0.042401325,0.09579348,0.041521955,-0.050770175,-0.0067750253,-0.036672845,0.053892013,-0.022030149,0.09769183,0.074999,-4.0643748e-08,0.059698507,-0.054046944,0.035133466,-0.09928982,0.07878463,0.07673531,-0.04120057,-0.03330076,0.005607659,0.005521632,0.041217152,0.018721413,-0.05855137,0.03887899,0.024368191,0.07263119,-0.09508193,-0.03685916,0.026715044,0.049571153,-0.03554595,-0.039128665,-0.082733504,0.06788573,-0.0862789,-0.035452362,0.0019199293,0.07575018,-0.07337455,-0.025608456,0.045990374,0.017620549,-0.08908938,0.0007034243,-0.0392324,0.04668518,0.002633245,-0.09050558,0.0088428985,0.02613651,-0.07227516,0.03546781,-0.11556111,0.027696574,0.014671582,-0.011816934,0.052075494,0.053446714,-0.03784096,-0.010688655,-0.002164805,-0.0380155,-0.055949498,-0.050289143,-0.03320006,-0.0053166994,0.050119746,0.017828664,-0.13443373,0.033450224,-0.07014886,0.022288615,0.17508997,-0.054152936 +4.4.1.32,"The enzyme, characterized from the cyanobacterium Synechococcus elongatus PCC 7942, catalyses the covalent attachment of the phycobilin chromophore phycocyanobilin to cysteine 84 of the alpha subunit of the phycobiliprotein C-phycocyanin.",384,1.0,-0.107522346,-0.029940477,-0.088196315,0.019687427,0.033159614,0.05347861,-0.032928187,0.008782682,0.0017154084,0.0051203095,0.04760165,-0.06252638,-0.075282104,0.08961645,-0.09268173,0.045569252,-0.09264707,0.019622166,-0.009931215,0.06554107,-0.0007856978,0.016488174,-0.048729133,0.054035842,0.011805048,-0.018542424,0.011544575,-0.002129027,-0.053038042,0.0461674,-0.04305725,-0.0770595,0.07327279,0.0055502183,0.091358155,0.031515647,-0.03068999,-0.12790947,0.08339258,0.013031094,0.077051006,0.019311598,-0.02103252,0.021470482,-0.007902576,0.027601045,0.03025192,-0.004739178,0.06299628,-0.008913676,0.012464689,0.0012685688,-0.083665945,0.017347014,-0.002736373,0.056085706,-0.08330014,-0.008411682,0.073999725,0.0340014,0.037962683,0.007027609,0.03400907,0.032168187,0.041597713,-0.10879508,-0.00450576,-0.02774309,0.049122244,-0.042414416,-0.027459329,-0.03744441,-0.011782187,0.0059725037,-0.017810758,0.110074356,0.04153242,-0.0013893049,-0.027133757,-0.08441256,0.049450744,-0.03809169,-0.044731826,0.06705825,0.052934848,-0.03604631,0.019078858,0.015504299,0.023650583,0.017771993,0.069139645,0.043875415,0.016345024,-0.13110943,-0.0853545,0.018145563,0.06678413,0.017977202,-0.031773865,0.016757924,-0.013208626,0.042570688,0.12511714,-0.10452177,-0.0062364163,0.014823707,-0.0027372376,0.03006538,0.054470684,0.0055598733,-0.029705662,0.009833634,-0.021810614,-0.060773898,0.029405374,0.024575925,-0.047333464,0.024095543,-0.019542798,0.05922929,-0.013238337,-0.0705969,0.03485646,0.017429244,-0.046447363,0.0072472985,-0.06528726,6.55137e-33,0.07049527,-0.017696869,0.020953387,-0.07404217,0.029767904,-0.025842005,-0.029126974,0.041978754,-0.0419798,-0.08272927,-0.05273597,-0.023328396,0.1109936,-0.015429492,-0.09998951,0.0035539053,-0.054311045,-0.04043499,0.056327198,0.043705855,0.028197926,0.025401913,0.0017891643,0.047400422,0.013186252,-0.042648975,-0.09769075,0.007900826,0.02880206,0.0018709536,-0.021468595,-0.044562664,-0.1176507,-0.024146166,0.07354243,-0.057268567,-0.006759809,-0.11268404,0.025385208,0.008971239,-0.04958698,-0.07774863,0.021382222,0.014233372,-0.0054392214,0.041422896,-0.021526726,0.058212906,-0.027328514,0.0059753824,-0.0055220593,-0.07309832,0.008404418,0.0100550065,-0.04486733,-0.038200773,-0.009605161,-0.020435799,0.036771476,-0.017871767,0.04791674,0.067944,-0.0560417,0.021725764,0.0021910663,-0.015405423,-0.08349572,-0.021650363,0.0293282,-0.020568227,-0.010894216,-0.039388675,0.007097391,0.0049865847,0.022375746,-0.024074953,-0.044825,-0.045925144,0.039660532,0.014094289,-0.06582058,-0.0068110125,0.0018248407,-0.025878115,-0.031429894,0.024899889,-0.002235046,0.0011064708,-0.019359306,-0.013529955,-0.013935863,-0.0557177,0.006467837,0.020289235,-0.012402574,-6.93855e-33,0.10559221,-0.10455827,0.018103234,-0.02981419,-0.029398413,-0.013635394,0.003452614,-0.050487224,-0.06904124,-0.0582361,0.10919331,-0.08463117,0.02848922,0.018940838,0.036853556,0.0782659,-0.045629192,0.103274964,-0.0065569286,0.0275238,0.020333242,-0.055951085,0.03363654,0.029473413,0.061700255,-0.014174764,-0.041070186,-0.002818014,0.05475917,0.063801564,-0.11988217,0.028287448,-0.04894964,0.0028710559,-0.031192787,0.047191802,-0.016792145,-0.07330492,0.10617601,0.014650748,0.06290675,-0.016743744,-0.07001034,0.059150778,0.055903427,0.052489504,0.035658725,0.090993054,-0.016573487,0.024100497,0.038681783,0.04954737,-0.021273408,0.042699926,-0.021240374,0.14879774,0.10522989,0.0018907327,0.011878301,-0.007037492,-0.025000893,-0.09579409,-0.0118512595,0.025094692,0.067292415,0.09824582,0.02339341,0.13880587,0.01051657,-0.089872964,0.04826651,0.014961513,0.09113851,0.0032796152,-0.030818243,-0.020339228,-0.008501667,-0.052879035,-0.027970074,0.010749932,0.0495684,-0.047530632,0.0110775335,-0.009074938,-0.017360345,-0.019628247,0.06100132,0.011704041,-0.056595236,0.005424683,-0.002148163,0.027812084,-0.0074384995,0.106325746,0.09527883,-3.529454e-08,0.05921374,-0.023151191,0.045981888,-0.10599185,0.09897342,0.061130866,-0.015038235,-0.030413853,0.006400634,-0.004893085,0.028171312,-0.005283194,-0.074008666,0.03171263,0.043954317,0.060603276,-0.07125296,-0.010020847,0.013954967,0.04407616,-0.024380555,-0.051682003,-0.09670203,0.0725798,-0.073988564,-0.05158238,-0.005764916,0.07534408,-0.09414169,-0.03565495,0.03515072,-0.028002802,-0.0727156,-0.0038684504,-0.011756305,0.054818783,-0.029255807,-0.08739156,-0.034886315,0.025364416,-0.06697559,0.03527457,-0.094599985,0.0038508198,0.047662295,-0.01846887,0.018660365,0.050752543,-0.0344896,-0.001945618,0.014382528,-0.03741737,-0.02324216,-0.04749407,-0.019860217,-0.037263706,0.026298119,0.006547329,-0.1142992,0.023147058,-0.040367913,0.062178746,0.1609231,-0.04352699 +4.4.1.33,"The enzyme, characterized from the cyanobacterium Synechococcus sp. WH8102, catalyses the covalent attachment of the phycobilin chromophore phycoerythrobilin to cysteine 84 of the alpha subunit of the phycobiliprotein R-phycocyanin and its isomerization to phycourobilin.",384,0.99999994,-0.10964962,-0.044158313,-0.093773454,0.028804936,0.030633518,0.045572635,-0.03269339,0.011441891,-0.015057508,0.012930408,0.06485539,-0.022753816,-0.084368326,0.11410132,-0.08332671,0.045647684,-0.10688155,0.02066111,-0.017888198,0.07399818,0.018147554,0.029848248,-0.03888093,0.044680126,0.04016737,-0.010311567,0.020831624,-0.025242493,-0.045610737,0.0520593,-0.019467887,-0.092244245,0.04663477,-0.019970832,0.07489931,0.026182016,-0.015107982,-0.1276447,0.107070796,0.01133375,0.06460926,0.015565275,-0.0005761695,0.01122187,-0.018446544,0.031005884,0.034141965,0.0029568237,0.062474992,-0.013042559,0.0044907215,0.0053539285,-0.06985602,0.028979056,0.025767954,0.066830516,-0.08923437,-0.012151224,0.014306434,0.023753807,0.033610452,0.016035946,0.024985695,0.032299865,0.04098672,-0.09269464,-0.012646852,-0.02979651,0.043032743,-0.041603662,-0.022788776,-0.041037202,-0.0033343176,-0.015811343,-0.005107102,0.10671037,0.031665146,0.020757044,-0.026562393,-0.077211305,0.048107196,-0.041817036,-0.03429753,0.09136615,0.048904303,-0.05282978,0.021653157,0.008613831,-0.0023181338,0.035617705,0.06902635,0.03957082,0.03710286,-0.13208401,-0.10300571,0.027570464,0.045200765,0.021723894,-0.018319033,0.024199434,-0.019526877,0.018110186,0.10300472,-0.09370526,-0.0027028045,0.029888883,-0.0072448784,0.016535504,0.05407383,0.0020926818,-0.017091038,0.020674007,-0.017703725,-0.03930872,0.013141492,0.03516401,-0.050838474,0.029278148,-0.010166329,0.04689833,-0.0047697504,-0.052090306,0.031519778,0.020335859,-0.06084212,0.0070742327,-0.070919596,7.101385e-33,0.07885168,-0.013009503,0.020396762,-0.09173691,0.026726471,-0.025500588,-0.04743048,0.041026596,-0.021878934,-0.063297026,-0.04837098,-0.02420563,0.0875374,-0.028603872,-0.10805168,-0.013235922,-0.058358617,-0.013745917,0.07647742,0.04832142,0.027876344,0.04690879,-0.010422489,0.05836459,0.012538905,-0.027622832,-0.09041877,0.0063896957,0.034718446,0.0035324837,-0.005257517,-0.07845856,-0.12787049,-0.029417805,0.045527972,-0.07048551,-0.011697206,-0.116556935,0.016626451,-0.004215899,-0.015763134,-0.08074027,-0.009642758,0.03416485,0.00020725893,0.057653323,-0.0027876224,0.048092954,-0.008507703,0.033335015,-0.022455262,-0.0694139,0.02808912,0.015730895,-0.051222734,-0.039625518,0.00024418597,-0.012815227,0.051287193,-0.02705919,0.023296665,0.06667438,-0.042191382,-0.02033766,0.012283778,0.012415668,-0.06286515,-0.051113974,0.030952431,-0.008630601,-0.021451345,-0.029258471,0.0070662973,0.022226427,0.035112455,-0.03067616,-0.026369609,-0.048379835,0.044256367,0.009068011,-0.073562644,0.025327528,-0.0069757556,-0.018584283,-0.011325527,0.036100335,-0.002828937,-0.010502617,-0.022659542,-0.016853027,-0.0062641352,-0.055453792,0.0027395329,0.00809705,0.0026748874,-7.190591e-33,0.08150037,-0.11173401,0.013850663,-0.028207019,-0.030736258,-0.029804513,-0.0016081439,-0.021840893,-0.06581091,-0.056026764,0.095540464,-0.07141139,0.020390254,0.026589487,0.030740034,0.07067432,-0.05355733,0.10771438,0.009201945,0.01644717,0.0141591625,-0.020254314,0.045517385,0.03404779,0.055307962,-0.017757578,-0.038230907,0.017013436,0.061139263,0.0723977,-0.10609454,0.040071916,-0.06864786,-0.020375997,-0.04351483,0.06194401,-0.03891067,-0.06927967,0.07395498,0.008659755,0.049798165,-0.025545256,-0.06336012,0.05353492,0.055555277,0.046913896,-0.0038562415,0.07901373,-0.019132145,0.021865664,0.025041323,0.06914094,-0.026195338,0.032431457,-0.0127247,0.15016408,0.08074027,0.020228872,0.018098408,-0.014491439,-0.029298993,-0.09755569,-0.0072929203,0.03055634,0.04811915,0.093220204,0.027590735,0.12846766,0.009070526,-0.07479111,0.046908047,0.03084867,0.1285026,0.0059864204,-0.0065764994,-0.006087546,-0.01329751,-0.06900824,-0.031224651,0.028941551,0.053560987,-0.034883082,-0.011467163,-0.010262608,-0.031354886,-0.018818595,0.07802595,0.028078588,-0.06688907,0.008368441,-0.0002201982,0.023989253,-0.01454394,0.09006466,0.06778053,-3.9089247e-08,0.05995703,-0.047986712,0.06040656,-0.102896474,0.105511025,0.070673496,-0.024968047,-0.03868799,-0.008162807,-0.011141683,0.032470867,-0.021441052,-0.09127487,0.035801116,0.0355319,0.07083284,-0.08271164,0.0022596428,-0.0019475011,0.039753348,-0.013035949,-0.044390094,-0.09701733,0.07423743,-0.048504308,-0.032484766,-0.005490089,0.046637315,-0.09624964,-0.042139877,0.056779318,-0.0042010774,-0.0738763,0.009376387,-0.030549858,0.040573083,-0.025774429,-0.06282177,-0.04769513,0.026805889,-0.07423486,0.03353797,-0.0974265,0.031060634,0.03742188,-0.0147993835,0.014639759,0.06794236,-0.04562088,-0.01529964,0.01754528,-0.035833042,-0.0480597,-0.06314272,-0.044474963,-0.03429045,0.033340022,0.008261752,-0.139764,0.037503075,-0.056582253,0.06102778,0.17393243,-0.04880371 +5.1.1.20,"The enzyme, characterized from the bacteria Escherichia coli and Bacillus subtilis, is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. In vitro the enzyme from Escherichia coli epimerizes several L-Ala-L-X dipeptides with broader specificity than the enzyme from Bacillus subtilis. ",384,0.99999994,-0.105902374,-0.12895451,-0.01741786,-0.03426767,0.06659704,0.010100837,-0.017363356,0.053713076,0.058812995,-0.031960208,0.05211402,0.008135519,-0.02084279,0.087130405,-0.047673285,0.061999228,-0.08100179,-0.012051025,-0.04270905,-0.01711213,0.103955746,0.043530125,-0.04518115,0.037384823,0.07464195,-0.046763435,0.05452601,-0.036991503,0.062917165,-0.04163395,-0.011400911,-0.008750852,0.0147413695,-0.05617437,0.04096069,0.048354283,-0.05199573,-0.05664806,0.106739275,-0.001377334,0.03908929,-0.016248832,-0.013776819,-0.07067535,-0.031357035,-0.003050198,-0.0017990416,0.04372308,0.017156783,0.039181143,0.026604077,-0.07427624,-0.023194905,0.019107994,-0.017058775,-0.055721827,-0.06779993,-0.070132844,0.018824378,0.017461754,-0.018052416,0.037009545,0.108789586,0.03184811,-0.027435865,-0.08301819,-0.0058725523,-0.087020956,-0.027532324,-0.08150582,-0.03960346,-0.07620842,0.0038145501,0.053012937,0.09497719,0.013523884,-0.015543144,0.0051845983,-0.04077586,0.01837957,0.11261689,0.03325549,-0.014595235,0.12799363,0.023804434,-0.0152567355,0.03273242,0.016229238,0.0131551875,-0.07673174,0.06478949,-0.10044843,-0.047387227,-0.03776842,-0.00888987,-0.021811726,-0.043661915,-0.05634542,0.0025752615,0.008138058,-0.08762769,0.0733813,0.017076738,-0.0029487936,-0.075878814,-0.05693972,0.03165144,0.074597895,0.033170577,-0.118464984,0.05178844,0.007744651,0.07511589,-0.017208636,-0.036466938,-0.012410921,0.0654103,-0.058262553,-0.04070427,-6.7342255e-05,-0.0032846534,-0.04985679,0.07221345,0.10531228,-0.017439654,0.03791141,-0.031242643,2.1418053e-33,0.09401789,-0.035665162,-0.014807776,0.003201776,-0.024406081,-0.037440374,-0.066471316,0.0021021268,0.0019429773,-0.031287044,-0.06885433,-0.07844838,0.020861818,0.07747896,0.0028781753,0.017490957,0.032309897,0.015936887,0.019501356,-0.049384326,-0.013070848,0.015921623,0.014138247,0.039411258,0.05336999,0.103986405,0.01792254,0.015945144,0.022220127,-0.020478932,0.002609482,-0.042878985,-0.107748814,0.06861802,0.022429977,0.026313884,-0.013175518,-0.02797102,0.08688896,0.057072718,0.0038074574,0.04665837,0.02234335,-0.08178498,0.06999493,-0.038970936,0.004380108,0.019459704,-0.013070646,0.03698519,0.0933032,0.0047797305,0.047321808,-0.029700993,-0.048001416,0.034669645,-0.028014876,0.0057802857,0.026419237,0.034414433,0.028837837,0.038166028,-0.072028466,0.030378565,-0.043579467,0.023899915,-0.029543689,-0.026760666,0.01756944,0.08329084,-0.06709757,-0.037214495,0.021149272,0.011623779,-0.00364861,-0.062091086,-0.03152486,0.047789607,0.05499591,0.008859009,0.024243897,0.014779311,-0.029253192,0.005333238,-0.0947521,-0.024896683,0.028577337,-0.10597291,0.028834803,0.0133803785,-0.061043106,0.0056206067,-0.03659782,0.019644773,-0.0030015982,-3.0593006e-33,0.085574605,-0.15343916,0.053396206,-0.071988024,-0.11020183,-0.0044011157,0.01228343,0.030694999,0.03343723,0.0030605684,0.009526807,0.022814188,-0.03784911,-0.040672574,0.020949742,0.055972755,-0.04560393,0.042457364,-0.023926862,-0.050928988,0.0052907453,0.02799608,0.14902142,-0.09243401,0.10773579,0.033613198,0.017871136,0.08844819,0.10598863,-0.03876514,-0.087024815,-0.0035473497,-0.0067952783,-0.045518294,-0.10523959,0.02398849,0.014211834,0.06435371,0.026384985,-0.09659963,0.015802927,0.06142096,0.029474357,0.027677892,0.06921134,0.04622564,-0.006453225,-0.03598147,0.03701311,-0.08462967,-0.017704276,-0.03665543,0.06479924,-0.06865788,-0.026660023,0.044165984,0.015137533,0.003491048,-0.038472246,-0.03688486,-0.0029530202,-0.05060471,0.025414292,0.015974289,0.02518497,0.06570303,0.022837771,0.0019345211,-0.0008617816,-0.048424132,0.070089735,-0.040598024,0.00040395278,-0.004643716,-0.016528774,-0.004871717,-0.1334197,-0.057478562,0.067975774,-0.07119387,-0.06138162,-0.03177257,-0.080730595,-0.011983118,0.023150846,-0.01802582,-0.021527603,0.0903421,0.062161848,-0.015619746,-0.06920805,-0.009876499,0.06342411,5.024835e-06,0.076483786,-3.7437648e-08,0.041503612,-0.020100394,-0.01673313,0.00047765137,-0.0017012479,-0.00033070345,-0.04379259,-0.031952873,0.018617254,-0.037367605,-0.02879749,0.070642695,-0.075742245,0.00089382584,0.025015121,0.068936765,-0.06173109,-0.0028214555,-0.0014641706,0.042616248,0.0013334196,0.018236628,-0.02825378,0.032724686,-0.012318093,-0.051626112,0.008838343,0.07094928,-0.042083424,0.0145684,-0.044995114,0.04951368,0.028833486,-0.04472617,-0.022956725,0.013237908,-0.11187987,-0.047700107,0.009126774,0.022016289,0.059109922,0.03878529,-0.016913012,-0.044212915,-0.031149983,0.019437583,-0.022525975,0.057013564,-0.008704923,-0.0029543117,0.06150601,-0.069320194,-0.022321474,0.022310218,-0.10877939,-0.0141367065,0.027784336,-0.07080577,0.0819158,-0.089214586,0.019760327,0.057243597,0.15966707,-0.020648679 +5.3.1.32,The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule 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+5.5.1.26,"The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin.",384,0.99999994,-0.025490774,0.018102044,-0.12498748,-0.04706609,-0.019461151,0.051816385,-0.062301375,0.03163911,0.12190303,-0.06612645,0.0026100138,-0.032466467,0.029126395,-0.02357339,-0.083088286,0.025526587,-0.020343062,-0.004543464,0.032093067,-0.027282268,0.09591196,0.06375302,-0.006619954,-0.0378705,0.062004037,-0.028879296,0.016327506,-0.05624845,-0.05812831,-0.08570579,0.08448616,-0.003452405,0.004098746,-0.04508941,0.11721253,0.0943793,-0.06963982,-0.037724398,0.10439481,0.043330643,0.021482408,-0.032138407,-0.009335362,-0.0147883175,-0.072777264,0.0562355,-0.003152775,0.0072463052,0.008360103,-0.03445412,-0.07214168,-0.059965197,-0.02581765,4.6865895e-05,0.11430481,0.03578573,-0.007819034,-0.031619776,-0.06709168,-0.050893124,0.0899496,0.0007880851,0.06068578,-0.00739096,-0.08557368,-0.0054685012,0.021066504,-0.0835872,0.06293966,-0.05518836,-0.11199969,0.019490028,-0.05000204,-0.0010584699,0.004803575,-0.044406448,-0.067553736,0.032643072,-0.013521247,-0.003907596,0.04090418,-0.00045724667,0.01063462,0.069331884,0.045425296,0.011763567,0.057202127,0.05625494,0.08421389,0.030616974,-0.022978395,-0.03289081,-0.021237146,-0.044635557,-0.03605663,-0.033434287,-0.06167352,0.00027575155,0.023020666,-0.008796678,0.0034793678,-0.010409831,0.015325842,-0.052965548,-0.05706158,0.016249934,0.016641838,0.021805786,0.07831633,-0.03909914,-0.024288194,0.016034955,0.023460945,-0.029265374,-0.040193338,0.06904189,0.09580589,-0.07291081,-0.053045303,0.011179965,0.015843159,-0.031144818,-0.0003001772,0.061660647,-0.043288436,0.054083064,-0.13548584,5.2850327e-34,0.015705004,0.060506035,0.058467675,-0.0645202,0.042465556,-0.013045069,-0.05638521,-0.06725043,-0.009753456,-0.099435836,-0.07289053,-0.10716257,-0.053506505,0.035201214,0.044882514,-0.012392408,0.0019200527,0.05472481,0.044639602,-0.0039261533,0.0044964296,0.05141832,-0.07930918,0.018743422,0.012358649,0.05722659,0.025819913,-0.0063605965,0.06049436,-0.03850338,-0.0011584329,-0.07197165,-0.04678164,0.03129278,0.09230141,-0.0069814166,-0.049901124,-0.007983993,0.02880586,0.032688342,-0.04989014,-0.0075526247,0.0058210744,-0.010955207,0.02527523,-0.018492332,-0.04969812,0.08200893,0.06876616,0.06863206,0.019266183,-0.0038575951,0.118414916,0.040504057,-0.065607026,0.017966151,-0.05067334,0.030253606,-0.028130842,0.0005271742,-0.016503967,-0.026262326,-0.007684599,-0.022775287,0.059925973,0.014678274,0.013782874,0.024299402,0.03964286,0.017598609,-0.075436406,-0.02043043,-0.0028654728,0.04856615,0.00853615,-0.0011036065,-0.1103877,-0.040200688,0.07034154,0.031161869,0.008886295,-0.0058065658,-0.008801184,-0.13102025,-0.08515638,0.021622026,-0.013389887,-0.044668596,0.019361943,0.081027575,0.003597012,-0.11553972,-0.061071537,0.069198005,-0.0041786893,-2.6881319e-33,0.08103109,-0.086514816,0.07371177,-0.009750976,-0.012531634,0.07142699,-0.011785355,0.01097135,-0.0046440875,0.007836803,0.064695746,-0.040429436,-0.01991982,-0.045705672,0.038182206,-0.009408098,0.038113568,0.1376307,-0.010329985,0.04394507,0.008350212,0.06660459,-0.054993723,-0.0003261417,0.018611826,0.0898182,-0.0019084691,0.09699109,-0.011466591,0.042667683,0.016036587,-0.018627893,-0.039948855,-0.041691627,-0.02000449,0.06279571,-0.052970212,0.05411864,0.08922253,-0.0013738595,0.054657374,0.007014057,0.066105105,0.07980667,0.022558404,0.019418146,-0.10761166,0.031468797,0.023458954,-0.10454192,-0.03632947,0.064987555,0.04737771,0.0044301446,-0.009795359,0.04574525,0.014215158,0.008578726,-0.03907028,-0.052109875,-0.07063898,-0.04726851,0.031361654,0.045276262,-0.0023523744,0.023983806,-0.018613739,-0.0076215733,0.06305798,-0.023570603,-0.014245104,0.021126654,-0.040673837,0.07869666,-0.004092474,-0.037102718,-0.11285821,-0.02599915,-0.012180789,-0.025658397,-0.018588489,-0.04828339,0.0089004375,-0.13224453,-0.00228237,-0.052754525,0.101513304,0.009264713,0.03688899,0.01863691,-0.014278048,0.054519612,-0.0715728,0.0628999,0.02068566,-2.8124218e-08,0.058981553,-0.082797654,0.03471472,-0.02893203,-0.01406391,-0.045385025,-0.0021056652,-0.02900522,-0.030057833,-0.026095508,-0.015403038,0.032131333,-0.025020825,-0.013704851,0.03392951,0.0063166833,-0.04225488,-0.023531735,0.0188513,-0.056277636,-0.07495468,-0.012005879,-0.09947092,0.03825594,0.04638063,-0.035170183,0.05200555,0.05377051,0.03789163,0.008676265,0.022537585,0.038355466,-0.040439084,-0.0056526973,-0.0959219,0.024408128,-0.04058918,-0.038861796,0.0837496,0.0049358797,0.027231645,0.023688156,-0.065104015,0.007911874,-0.02781739,0.047751747,-0.02026217,-0.03205913,-0.068664886,0.017400173,0.045254346,0.02380812,-0.03582958,0.036098585,-0.117126,0.050596513,0.016429026,0.01740495,-0.05940811,-0.047815073,-0.04047968,-0.03549,0.20043898,-0.058465432 +6.3.2.46,"The enzyme, characterized from the bacterium Enterobacter agglomerans, is involved in biosynthesis of dapdiamide tripeptide antibiotics, a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the presence of an L-2,3-diaminopropanoate (DAP) moiety and two amide linkages in their scaffold.",384,1.0,-0.11412727,-0.08575182,-0.16277765,-0.019859549,0.003259995,-0.0016894084,-0.05385713,0.08182604,0.042813003,-0.017088862,-0.012454048,-0.07664433,-0.07046499,0.05530273,-0.021151256,0.084660485,-0.03117045,0.019660933,0.029505843,0.029185154,-0.0042153774,0.04689054,-0.0023979745,-0.0071241786,0.025296424,0.005772,0.059940167,0.028347183,-0.03086293,-0.065774836,0.028043693,-0.02367011,0.06795273,-0.023126414,0.10329759,0.052914187,-0.03600912,-0.021762691,0.092504516,-0.020677716,0.053159796,0.024674961,0.041504182,-0.02436705,-0.003687322,0.0027784586,-0.058846336,0.122102365,0.04749688,-0.001749406,-0.065490656,-0.012224844,-0.050430067,0.041450627,-0.038938798,-0.009326919,-0.011832324,-0.044115648,-0.10494943,0.02776275,0.023771994,0.03290016,0.0043034437,0.010252684,-0.082822666,-0.037529904,0.008463636,-0.09714877,0.02899057,0.004651195,-0.107081585,-0.07593921,0.037601788,0.060302563,-0.0021419774,-0.013265286,-0.016191492,0.078600414,0.016296206,-0.062087778,0.08896517,0.051962946,-0.008169412,0.093213335,0.020121079,-0.007778321,0.0009966937,0.02515021,0.07837292,-0.008769513,0.04220523,-0.060332097,0.0034372353,-0.04094999,-0.06057613,-0.06353726,0.021318493,-0.015354229,0.0155792665,0.031106582,-0.04688224,0.024400793,-0.00047940706,-0.065418914,-0.06483897,-0.07992503,0.022884704,0.05821469,0.033326175,-0.008064507,0.01212611,0.009953867,0.07160585,-0.014094844,-0.054844573,-0.006775153,-0.0038804188,-0.13205895,-0.0020453467,-0.029686702,-0.010840957,-0.05556195,0.07506502,0.060899623,-0.05907397,-0.044458132,-0.06279185,2.5389635e-33,0.06297529,-0.00031132787,0.026829662,-0.048527908,0.028507497,-0.04645189,-0.07054348,-0.027325097,0.016100038,0.009901293,-0.11481167,-0.08548179,0.049392518,0.07323217,-0.027698006,-0.010213479,-0.015032908,0.0688174,0.007904801,-0.04809912,0.027326006,0.039096177,0.007824768,0.07043205,0.094910495,0.09304412,-0.01774323,0.023145543,0.11045742,0.008425902,0.0002205829,-0.10759112,-0.08597861,-0.0056040054,-0.0058231517,0.0072010313,-0.055949055,-0.12474157,0.02299736,0.030028904,-0.0066023604,0.032278895,-0.020389775,0.0058334977,0.049414095,0.005731389,-0.022823138,0.09757011,0.021100443,0.04374825,0.045802392,-0.08103556,0.067739986,0.05171501,-0.07698446,0.012779209,-0.084532395,0.008441889,0.08414597,0.004382296,-0.055929143,-0.020731201,-0.021474708,-0.022119764,-0.014473488,0.0030649756,-0.01948651,0.015550264,0.054202802,0.104267366,-0.025343142,-0.038088005,0.018577712,0.08656613,0.028571144,-0.05904569,-0.035034426,-0.021235684,0.06923902,0.022373928,0.01301128,0.0004526676,-0.0020742337,-0.03708281,-0.047191706,-0.017700274,0.0067610196,-0.05640592,-0.022682505,0.0230752,-0.013118531,-0.032520425,-0.039532803,0.076412834,0.08384078,-4.9583325e-33,0.06525701,-0.11278122,0.01895409,-0.04933351,-0.030068096,0.009263698,-0.030845826,0.08150226,0.047264963,0.004896189,0.037588976,0.033769246,0.06026463,-0.058427602,0.03171681,-0.046735976,0.0072495206,0.048278734,-0.025245275,-0.011257343,0.053231463,-0.03506175,0.029016694,-0.0847789,0.032308772,0.043263216,-0.016208153,0.06288748,-0.004447868,0.08314175,-0.00041042586,0.072203755,-0.05214869,-0.05731745,-0.016217513,0.06209509,-0.030049805,0.025162043,-0.052783635,-0.05048889,-0.0015949747,0.06676791,0.018524798,0.059328247,0.019935427,0.036920458,-0.076856464,0.032888293,0.025615044,-0.12453311,-0.015683496,-0.007536132,0.0003548081,-0.015410152,-0.0046910243,0.04752605,-0.0135662295,-0.05663974,-0.06811564,-0.0014872195,-0.049861304,-0.09903024,0.04565965,0.03231298,0.031241018,0.032930348,-0.0060791615,0.05654473,0.055773016,0.018803272,0.025209306,-0.005999006,-0.0067759138,0.049372863,-0.023590682,-0.0127863055,-0.10686979,-0.052383132,0.026063437,0.0025495628,0.01157914,-0.07605442,0.029496681,0.054165363,-0.11342778,-0.06712939,0.056538407,0.09904064,-0.049611554,0.060319986,-0.015804807,0.009062697,0.022720508,0.09941957,0.030160453,-4.1878167e-08,0.084144674,0.00067824894,0.10299792,-0.014827569,-0.04735999,0.011552895,-0.09782433,-0.0006617301,0.00252761,-0.03085101,0.015810244,0.07485287,-0.045457803,-0.0032849887,0.035475206,0.025132604,-0.012647484,0.0060644257,-0.029500552,0.026987486,-0.037731737,0.022284105,-0.023601782,-0.023705253,0.05955444,-0.014601171,-0.043077305,0.010764508,-0.03483648,0.05203242,-0.0060660737,0.057780012,-0.004675078,0.03233157,-0.09806122,0.0003585382,-0.05331289,-0.1142936,-0.016593676,-0.061121024,0.050868973,-0.010089816,-0.04465083,0.006804275,-0.023652801,0.040605813,0.029345615,0.0029288437,-0.1011124,-0.06361198,-0.00018131883,0.0075044474,-0.04632044,-0.002252938,-0.087769486,-0.0028566436,-0.0776777,-0.03351261,-0.020978292,-0.039713945,-0.06464808,0.016976694,0.17949663,0.008788199 +6.3.2.47,"The enzyme, characterized from the bacterium Pantoea agglomerans, is involved in biosynthesis of dapdiamide tripeptide antibiotics, a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the presence of an (S)-2,3-diaminopropanoate (DAP) moiety and two amide linkages in their scaffold. ",384,0.99999994,-0.09354526,-0.041064434,-0.15266052,-0.04075435,0.03057575,0.005642108,-0.042554855,0.07201918,0.051168013,-0.031342763,-0.040169027,-0.050950583,-0.065411806,0.0575555,-0.031099308,0.08359301,-0.05098142,0.036296226,0.020269498,0.014493464,0.009837113,0.07093464,-0.0062391614,0.017631348,0.03485617,0.030998632,0.044941626,-0.002451027,-0.07035558,-0.028840728,0.009813017,-0.0042176284,0.043176163,-0.020292534,0.0881727,0.038179126,-0.04822302,0.0029876865,0.08462868,-0.041440573,0.059084885,0.038616322,0.045244467,-0.040670842,3.795685e-05,0.024342561,-0.052853208,0.09765482,0.03418755,0.022465315,-0.083935544,-0.021222608,-0.034674834,0.019402886,0.01579747,0.0007161725,-0.031183131,-0.07659698,-0.10208692,0.026474737,0.021126948,-0.0070928326,-0.048908707,0.027817773,-0.060306676,-0.053240884,0.036930244,-0.093886495,0.03106663,0.010840395,-0.10671278,-0.06497341,0.05480907,0.059647325,0.026128221,0.0017374016,-0.024898203,0.06935163,0.03390891,-0.0692306,0.0655969,0.060300115,0.0026514332,0.11138248,0.044268433,0.0072030365,0.0029699893,0.029868953,0.06241068,-0.02286885,0.053977583,-0.025845135,-0.00556324,-0.03656596,-0.087887906,-0.05616389,-0.004208556,-0.018452402,0.001980647,0.048996642,-0.00676303,-0.0023830193,-0.00644438,-0.0714258,-0.08951465,-0.064871244,0.015838884,0.052660134,-0.0035435911,0.01770144,0.04426407,-0.010802111,0.062865704,-0.04651752,-0.057638295,0.026890816,-0.018142039,-0.103245266,-0.020103965,-0.055117074,-0.002918726,-0.08152823,0.07101349,0.075779445,-0.06666664,-0.03453784,-0.054393813,2.5213463e-33,0.07699598,0.025246145,0.0409734,-0.028076004,0.028732648,-0.049688186,-0.04345337,-0.006267093,-0.019423505,-0.0047455635,-0.120884836,-0.049184594,0.022740755,0.05621337,-0.04653372,-0.012078743,0.020391705,0.04378045,0.043295834,-0.069750614,0.03475358,0.085839994,0.0014057285,0.08284095,0.082395405,0.05552818,-0.005715143,0.02278375,0.077849545,0.024940439,0.018286115,-0.07133457,-0.06141289,-0.0026087835,-0.011525338,0.0090149455,-0.059540834,-0.12085387,0.013183505,0.10751783,-0.008347645,0.021733252,0.0028012404,0.013641814,0.04057935,0.013142649,-0.022940349,0.10201527,0.0032642656,0.047149967,0.009363457,-0.08433907,0.091059074,0.059653703,-0.09667442,0.028410053,-0.08884867,-0.0025646521,0.10023727,0.024884226,-0.05301007,-0.015567398,-0.0467131,-0.051557656,-0.0070952256,0.026693676,-0.020090433,-0.0047553284,0.0304215,0.0953401,0.008452637,-0.011747878,0.0060815173,0.11023158,0.051441107,-0.07326852,-0.021129917,0.002793679,0.04153643,0.037262987,0.035995238,0.018685382,0.007480395,-0.03633883,-0.07085505,-0.033120513,-9.7980934e-05,-0.029681519,-0.045736704,0.021001091,-0.0055402,-0.038917303,-0.009624924,0.06570579,0.07016381,-4.097478e-33,0.041246787,-0.13140152,-0.008011242,-0.012838087,-0.05630986,0.025129288,-0.020147223,0.03852405,0.031189023,-0.007501664,0.027055781,-0.003943286,0.06685156,-0.059308447,0.0013611712,-0.0397048,-0.006959189,0.048982013,-0.0202171,0.013761466,0.008288393,-0.012355126,0.021156553,-0.06407133,0.037843697,0.047660787,-0.01335928,0.042906955,0.01987776,0.089607716,0.0005951853,0.05647891,-0.068910584,-0.060174305,-0.027346855,0.08518193,-0.02572819,0.047419835,-0.06041086,-0.010891294,-0.029049743,0.060998205,0.050248295,0.035733342,0.059491813,0.018225767,-0.08694559,0.078593574,0.012653317,-0.13687238,-0.013954149,0.02509049,0.02006248,-0.03180963,0.031006847,0.029298814,0.012291713,-0.061660744,-0.044773035,-0.027833957,-0.0410315,-0.09845745,0.048087135,0.045826662,0.047640115,0.057976324,-0.04231124,0.05164951,0.02961063,0.0339314,-0.044934634,-0.027106447,-0.015389752,0.028829994,-0.057616193,-0.0005101287,-0.11639152,-0.034652136,0.032180756,0.03603947,0.025868094,-0.07935549,0.04657185,0.017682726,-0.13206878,-0.038705155,0.08009675,0.10061216,-0.027864536,0.05388533,-0.026676208,0.012755752,0.0005001798,0.08852566,0.013831491,-4.0702698e-08,0.11456551,-0.03366061,0.09720515,-0.021277983,-0.06762022,0.015757546,-0.038661975,0.0003960197,0.025843265,-0.060278717,-0.033783857,0.084003456,-0.023144273,-0.017577004,0.026433,0.049637202,-0.00016693224,0.0010074559,-0.0335931,0.017599408,-0.032969013,0.0139413765,-0.055330105,-0.017670274,0.054318644,-0.0263851,-0.017454097,0.024217293,-0.013946913,0.012587374,-0.043833442,0.01736599,-0.036546882,0.016751844,-0.07546093,-0.0074745305,-0.07836345,-0.110204645,0.009158214,-0.058093015,0.059355877,-0.025914265,-0.044501837,0.020953499,0.0040339287,0.03012643,0.06299594,-0.025163084,-0.100271896,-0.06389229,-0.022211088,0.025610423,-0.03729477,0.0040977127,-0.090140946,-0.02360586,-0.03513411,-0.043313447,-0.03495312,-0.045491636,-0.062301125,-0.0067957495,0.16556074,0.040162034 +1.1.1.387,"The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC 1.1.1.276, serine 3-dehydrogenase (NADP+)].",384,0.99999994,-0.08392992,-0.0560815,-0.0677371,-0.02149243,0.08600611,0.09164698,-0.12871982,0.11068586,0.021067502,0.0057544494,0.008253192,-0.016577026,-0.049056515,0.08013467,-0.04208571,0.025608849,-0.01258538,-0.013765972,0.073732615,0.016797163,0.04924801,0.083187155,-0.044662915,-0.0058600046,0.13303071,0.04743383,0.03719147,0.010781034,-0.01856,0.004434068,-0.08302691,-0.06906736,0.072698414,-0.07694901,0.062357564,0.090571254,-0.065561146,-0.0390371,0.1217477,0.02516067,0.02771913,-0.019108746,-0.08057577,-0.09136793,-0.027105121,-0.010465404,0.0046798615,0.04597757,0.016597496,-0.0052483357,-0.036721822,0.0017640102,0.04528806,0.047915284,-0.0725282,-0.05170831,0.039481256,-0.02640331,-0.06880768,-0.041934602,-0.0101977475,-0.046592448,-0.0038546398,0.0074241892,0.037962254,-0.05530212,0.04552172,-0.024026481,0.03634014,-0.046884015,-0.06671488,-0.013987948,0.044459876,0.08702514,0.00539438,-0.03784748,0.004706066,-0.028303897,0.038527146,-0.031726744,0.06554704,-0.027193338,-0.026043266,0.113137275,0.023145463,-0.052064143,-0.014217384,0.049471837,0.040538818,0.010474301,0.025640406,-0.0065005026,-0.11008625,-0.046439998,-0.07004579,0.054631133,-0.02137237,0.028137721,-0.04892895,-0.052964233,0.012757563,0.081067696,-0.040248457,-0.079359576,-0.0020972325,0.060726956,0.03538837,0.056410607,0.0112845665,-0.051741395,0.011993467,-0.07013857,0.011433869,-0.008069383,-0.04394431,0.066949986,0.057124924,-0.10009449,-0.09586543,-0.002439156,0.035648055,-0.053266175,0.117240004,0.06157698,0.022419387,0.034571737,-0.08125552,1.3361726e-33,0.06888168,0.036862556,-0.042333383,-0.08934115,0.05571569,0.01667512,-0.08297101,0.063554764,0.0115858745,-0.05382909,-0.034277894,-0.06290011,0.032804184,-0.019824494,-0.026786666,0.010110724,-0.0059589655,-0.032090202,0.051247027,-0.04119731,0.04435633,0.012310569,-0.0026422944,0.034553714,0.057868157,0.0433961,0.06099536,0.056211084,-0.01219389,-0.009791158,0.06983295,-0.09214846,-0.090843566,-0.038647033,0.105745584,0.024607297,-0.08175053,-0.029330632,0.029122593,0.081741415,0.016715849,0.08257906,0.013916657,-0.06256931,0.021746054,-0.06444963,-0.030791909,0.119689874,-0.004231269,0.06391734,0.1248592,-0.091111496,0.018486165,-0.098166615,-0.041453496,0.04064955,-0.020601885,0.025512386,0.051708918,0.07459317,0.085445516,-0.008948605,-0.032873344,0.052424237,-0.064745784,0.01818348,-0.10305298,-0.02873205,0.048475508,0.05555656,-0.05337787,-0.01178357,0.09107245,0.020253517,0.017643148,-0.032108318,-0.063803345,0.026197096,0.012039589,-0.019426636,0.011082735,-0.06026732,-0.0027643552,0.014313145,-0.061904896,0.023540985,0.022659129,-0.027579986,0.008129569,-0.026498493,0.047016487,-0.09178078,-0.01611757,0.0050264625,-0.0015416315,-2.3214566e-33,0.03124338,-0.053087067,0.07506217,-0.08309077,-0.048984706,0.08135841,-0.01916607,0.00596696,0.014973776,0.000872917,0.11173476,-0.0061522615,0.014298455,-0.025727175,0.081737496,0.05597832,0.008309394,-0.0048633455,-0.03469039,-0.033816904,0.02050649,0.02540621,0.020101646,0.00063817395,0.061987247,0.0003823017,-0.039776333,0.047894582,0.059282675,0.06282891,-0.021550022,0.048704248,-0.04172445,-0.062321123,-0.013418583,0.07088927,-0.0025572213,-0.01588967,0.03795017,0.014715176,0.0681774,0.016828716,-0.020244397,0.08780132,-0.0133315995,0.03378163,-0.05862237,-0.06852992,0.011062957,-0.101445325,0.034339502,-0.003696633,-0.018110858,0.021801235,0.019461773,0.050767045,-0.018119948,0.019626237,-0.035901193,-0.055254817,-0.015589677,-0.06319673,-0.03500404,0.0198112,0.058086764,0.009687611,-0.037725046,0.047416024,0.032104,-0.03752332,0.06012538,0.009196428,0.028872255,0.007126252,-0.063027166,0.003926451,-0.07424244,-0.021383613,0.0011233934,-0.010390918,0.018689366,-0.017167266,-0.067516014,-0.091613136,-0.03399693,-0.026650928,-0.0153359845,0.10713699,-0.0622587,0.027610244,-0.042337704,0.030760005,-0.02184952,0.04139207,0.029970648,-3.9551693e-08,0.04186861,-0.03265855,0.06395958,0.0050377306,0.0045770286,0.029978031,-0.009636958,0.009242039,0.006278255,0.005808806,-0.039736614,0.0602528,-0.057048514,-0.028128047,0.06832561,-0.024064593,-0.0590127,0.031574644,-0.03655002,-0.025837773,-0.045418605,-0.0018838607,-0.09809868,0.0035107262,0.028453581,0.010813804,-0.004793787,-0.06102748,0.04006911,-0.052790936,-0.036014874,0.029406931,0.044491667,-0.05397765,-0.07902941,0.013325291,-0.06117047,-0.034787152,-0.09843132,0.044728722,0.03894471,-0.01359258,-0.085077636,0.035456445,0.006280817,0.03561571,0.057937995,-0.02425345,-0.053559065,-0.092605054,0.06632287,-0.061964806,0.037511315,-0.009035736,-0.07427164,0.054133624,-0.036858227,-0.066936284,-0.03196727,-0.023422597,0.01217687,0.022323437,0.13932061,0.03305003 +1.1.1.388,"The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+). ",384,1.0,-0.05622095,0.007811031,-0.047700144,-0.0723772,0.011974112,0.04357281,-0.0793186,-0.018784108,0.05479883,0.021730537,-0.0026457855,-0.0040382696,-0.11831364,0.01888551,-0.048873074,-0.00868083,-0.08727278,-0.012319188,0.066884466,-0.0028216024,0.124941334,0.01602847,0.005425968,-0.040646788,0.09581859,0.042365354,0.08221148,-0.013608632,-0.012062632,-0.0962032,-0.043759644,-0.024744129,0.026836783,-0.078842446,0.08680212,0.08597665,-0.04068024,-0.030257205,-0.0032230227,0.026597932,0.040815774,0.0076416386,0.0070977784,-0.03304263,-0.056916337,-0.049902264,-0.021451853,0.09809003,0.0155967595,0.0106676705,-0.05351804,-0.0881841,-0.0014625964,-0.014217182,0.07490024,-0.011221153,0.029835217,-0.0053678616,0.021939758,-0.090531014,0.03399596,-0.041746333,-0.04343234,0.021255098,0.029408667,-0.059326254,0.08688466,-0.050071582,-0.039675448,-0.06556785,-0.11303627,-0.0061733774,-0.017800828,-0.0143562695,-0.009818982,0.08944714,-0.10104595,-0.029730376,0.011904533,-0.006005762,0.050217967,0.05256724,0.005598534,0.066806175,0.080625504,0.0055692866,0.02176062,0.04720805,0.036346138,0.01056977,-0.022638468,-0.04802569,-0.0005284646,0.0025516748,-0.10921416,0.0370762,0.039919145,0.0127740735,0.03504149,-0.056068912,0.06300021,0.06474265,-0.03737657,-0.046835914,-0.029224819,0.066025324,-0.052677337,0.14665382,-0.0054946216,0.0017222401,-0.022251185,-0.030225782,0.07141717,0.007368035,-0.03262398,0.092195176,-0.036207233,-0.04389818,-0.06065675,0.04073379,-0.019657662,0.005413482,0.016848626,0.062401142,-0.03702989,0.06490016,-0.15613087,1.5424626e-34,0.09735004,0.04690328,-0.0014535752,-0.037373673,0.021635728,0.0048538363,-0.048718773,0.04110232,-0.09950426,-0.06133365,-0.07235726,-0.029514628,0.060188763,-0.0304241,-0.02322337,0.04296038,-0.008623046,-0.009842437,-0.0135091655,0.054949112,0.031315196,0.047586393,-0.04084925,0.0077303224,0.04105575,0.040435743,-0.0516324,0.019565951,-0.03230323,-0.006793369,0.065751694,-0.12138333,-0.05168642,-0.00010511457,0.10850008,-0.016013928,0.024688961,-0.07744609,-0.06272183,0.03239333,-0.057449684,0.021970399,-0.018334141,-0.016991997,0.0017695938,-0.07828981,0.0007763919,0.026492633,0.062304016,0.059992317,-0.013930171,0.0028610646,0.095416546,-0.06356165,-0.052641965,0.037747614,-0.05072872,0.004447314,0.034687866,0.055622287,0.048425525,0.04236308,-0.022609215,0.027922448,-0.029184781,-0.0048736306,-0.066524185,-0.020223005,0.034150388,0.09587743,-0.066062994,0.009356543,0.05073267,0.013406965,0.02229093,-0.03998694,0.021057889,-0.023089055,-0.0148585625,-0.001087591,-0.005798915,-0.04980268,-0.012177873,-0.08377208,-0.043293048,0.027397,-0.009553164,-0.05197061,-0.033329412,0.071231045,0.020263398,-0.027261702,-0.07189883,-0.0026486807,0.03490998,-1.2611962e-33,0.118628465,-0.05376083,0.041688856,-0.13685454,-0.07638055,0.12531178,0.048123088,-0.122897096,0.04441343,-0.053287573,0.014510667,0.06730158,0.07326538,-0.055105418,0.028880745,-0.03098905,0.005033374,0.052885145,0.043445375,-0.003380173,-0.007148299,0.110248335,-0.022467427,-0.005568242,0.018816063,-0.035826463,0.016597584,0.060924802,0.012578941,0.04148519,-0.012216203,0.027077843,-0.0309459,-0.027827468,-0.09560139,0.0067441235,-0.06725811,-0.019800995,0.034852628,0.077798665,0.009540353,0.00085380994,-0.03458505,-0.010992459,0.03529956,0.015983392,-0.050178926,0.042301465,0.028194996,-0.07212193,0.07098086,0.02113816,0.003945597,0.0686885,0.07137062,0.0024543281,-0.012357286,0.009259088,0.035293154,-0.013946767,-0.037261676,0.00464475,0.07195625,-0.0032530392,0.06650463,0.030906381,-0.017910885,0.01792445,-0.016417412,0.0038293635,0.003953217,0.03250586,0.016605694,0.0677244,0.011740713,-0.045627642,-0.114599355,-0.008183652,-0.0065899855,-0.06056253,-0.016063444,0.03599751,-0.0019950012,-0.06560687,0.020985607,-0.010392775,0.023914391,0.07523207,-0.02739465,0.04708859,-0.039883394,0.013037271,-0.01874074,0.0029324894,0.023186477,-3.4513867e-08,0.037042238,0.017161598,0.0159473,-0.020350093,0.01208837,0.035807658,0.09500624,0.004236733,0.06390142,0.01774996,0.021236328,0.08784245,0.10663529,-0.0050157793,0.047617823,0.021876985,-0.0036140548,-0.00758248,-0.034606233,-0.012936018,-0.04156128,0.0037662927,-0.07670213,0.06265462,0.046967454,-0.027319873,0.06389303,-0.0007949583,0.02892573,-0.056221116,-0.021609807,-0.0017793746,0.03814499,-0.098106876,-0.05398939,0.0840455,-0.02246015,0.0011789587,-0.009551544,0.026172774,0.0054655406,-0.09722781,-0.06665403,-0.02616066,-0.034513213,0.0970418,0.048319656,0.008341462,-0.09437498,0.034922164,0.02309,-0.015952988,-0.03438157,-0.03225179,-0.06280329,-0.0019683598,0.03261981,-0.102157265,-0.0014051696,-0.06122226,0.08073667,0.009511936,0.17694524,-0.05936357 +1.1.3.48,"The enzyme, characterized from the bacterium Shewanella oneidensis, is involved in the formation of 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate, an aminated form of Kdo found in lipopolysaccharides of members of the Shewanella genus. cf. EC 2.6.1.109, 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase.",384,1.0,-0.04612133,-0.07052794,-0.049914207,-0.03607093,-0.07625466,0.036136493,-0.025185559,0.064433895,-0.004513113,0.089991525,0.047688767,-0.083666556,-0.08879747,0.04571245,-0.009670681,0.02105837,-0.08207926,-0.0041204146,-0.0013127129,-0.028176658,0.11216398,0.06192907,0.022470567,-0.01502025,0.03951556,0.06752631,0.06047282,-0.008316219,-0.0109614385,-0.03931169,-0.07908576,-0.03113739,0.08020955,-0.04836416,0.10858044,0.08254795,-0.014965209,-0.06330573,0.08129237,-0.035010364,0.013643153,-0.0388225,0.08259203,-0.0818156,-0.0575682,0.0013863975,0.04779713,0.10825296,0.09717039,-0.04735513,0.005812827,-0.090516195,-0.00572955,-0.028066585,0.0072632125,0.03331778,-0.02444359,0.012651635,-0.015507902,0.0037169594,0.015821466,0.047253694,0.03206807,0.035431907,0.02132189,-0.054993104,0.040553916,-0.06032492,0.04223793,-0.02761923,0.039619423,-0.068468064,-0.014616371,0.07600081,-0.024638278,0.021571083,0.08097136,-0.011128604,0.049303938,-0.051501554,0.026381198,-0.041338954,0.02872735,0.08498296,-0.047893416,-0.03052585,-0.035898,0.033630844,0.105604045,0.0067597018,0.039738398,-0.0043992107,-0.022891387,-0.1006264,-0.04634613,-0.005140377,-0.015435779,0.04185083,0.06056506,-0.02953555,0.047634136,0.014969285,-0.043946203,-0.02084981,-0.03918872,0.004668669,-0.0030696113,-0.023128392,0.03649503,0.022732116,0.027127694,-0.01068566,-0.012579379,-0.049593035,-0.074596144,0.017549325,0.032138072,-0.072215565,-0.081164226,0.0071047586,-0.062108483,-0.07283945,0.09608047,0.10585969,-0.0417157,0.026335604,-0.07794257,-1.4288481e-33,0.018072672,0.018078376,0.045281913,-0.057437185,0.057595223,-0.04891704,-0.0366998,0.03425729,-0.07619859,-0.04657063,-0.13380186,-0.056103606,0.024626542,0.024973657,0.027815504,0.045581587,-0.014212183,0.010590551,0.06257532,0.03202024,0.032573335,0.06510226,0.02689134,0.027380403,0.06751863,0.062830515,0.025152633,-0.021150557,0.03077544,0.001739897,0.040210854,-0.09243704,-0.09969136,-0.047602903,0.00018575367,0.012338797,-0.07170402,-0.03776342,-0.007801193,0.06542109,0.0039270762,0.015349964,-0.012486733,-0.047929753,0.029384583,0.006579263,-0.020602275,-0.0040918663,0.044777088,-0.006161642,0.035422433,0.036548264,0.0735253,-0.020222867,-0.05035975,0.05455849,0.03831248,0.0016656455,0.10221514,0.053811494,0.020686107,0.08331195,-0.050804324,0.02767741,-0.006591446,0.03325948,0.0182406,-0.04068742,0.03431691,-0.012883237,-0.090334155,-0.048029885,-0.020575467,-0.0208735,-0.002145581,-0.03428952,-0.086781435,0.0073107793,0.021424396,-0.03641658,0.076741055,-0.017880889,0.018683545,-0.029558752,-0.021799607,0.012914257,-0.020422338,-0.04100072,-0.06943385,0.040539138,0.03370348,-0.06948292,-0.10480766,0.063098475,-0.018870959,-2.051555e-33,-0.00057230494,-0.10473849,0.0023746488,-0.061406504,-0.02259726,0.050481126,0.019000512,0.07960961,0.04140454,-0.029298391,0.12124918,-0.027276257,0.021828974,-0.04685389,0.008613196,0.017452247,-0.04951646,0.11613434,-0.01650048,-0.03197432,-0.056636196,0.024917023,0.030648582,0.017144566,-0.02568008,-0.02584301,-0.026760703,0.09349953,0.024510494,0.054543037,0.027450394,-0.016383234,-0.02172968,-0.039958246,-0.02259883,0.008623357,-0.027538467,0.009826453,0.09572874,0.022317242,0.021056702,0.068441086,0.068751626,0.0053516217,-0.04351999,0.04912106,-0.097722396,0.053228304,-0.050804887,-0.048125345,0.014267982,-0.012905828,0.0008597189,0.023264475,0.031051548,0.027791208,0.01704247,0.046482284,-0.043697275,-0.026838828,-0.092750564,-0.15899868,0.092061274,0.03565366,0.085350566,0.08494607,-0.0568978,-0.003972983,-0.003766274,-0.029330157,-0.026381446,-0.01294136,-0.018610178,0.05368754,0.005897578,0.018355772,-0.0982485,-0.04982696,0.066591255,-0.039783128,-0.030546505,-0.046582002,0.031748943,-0.0028619394,0.062296197,-0.07758609,0.10216188,0.10311664,0.03350973,0.059396215,0.0041892016,-0.015980827,-0.068146944,0.0034040122,0.045252636,-4.2335866e-08,0.03042317,-0.09713678,0.08314725,-0.060358573,0.0304861,0.026802108,0.001065696,-0.00078396336,0.096310906,-0.068964995,0.006933593,0.06744294,-0.020138402,0.015789803,-0.030378658,-0.018741176,-0.10082689,0.020415787,-0.033979826,-0.010461896,-0.09666352,-0.01781043,-0.03607413,-0.05926486,0.021427006,-0.0062793856,-0.004342267,0.026515348,-0.044986706,-0.018481,-0.06784293,0.012220028,-0.060630023,-0.03535511,-0.086311795,-0.015416491,-0.035141155,-0.039866697,-0.05067652,0.010869677,0.041767336,-0.05698097,-0.036102064,0.013796602,0.054818947,0.044715226,0.012087438,0.09165782,-0.042804316,-0.037649445,-0.009802955,0.013693016,-0.036331568,-0.09320539,-0.09365806,-0.05320696,-0.050492816,-0.035427514,-0.014611377,0.029212007,0.05664381,-0.014080599,0.1499653,-0.014390631 +1.2.1.93,"The enzyme complex, isolated from the bacterium Gottschalkia acidurici, couples the reduction of NAD+ and the reduction of ferredoxin with formate via flavin-based electron bifurcation. ",384,1.0,-0.09597785,0.055500273,-0.08925011,0.066885374,0.022489984,0.04767421,-0.1095796,0.041667357,0.022375617,-0.05915887,0.00221082,-0.007041797,-0.03857207,0.030782707,-0.06360871,-0.035748124,-0.10599717,0.05085649,0.024771765,0.025444182,0.03530551,0.003404481,0.027982142,-0.016052457,0.007305733,0.05726346,0.031098088,0.019706238,0.0044724243,-0.07383074,0.03251449,0.004626676,0.049128942,-0.06355055,-0.018700315,0.044375803,0.019237291,0.03148888,0.070237376,-0.06264332,0.002346681,0.032511324,0.014095695,-0.08945621,-0.018887226,-0.013115473,0.08284052,-0.0003034028,0.044753443,0.03948332,-0.073635854,-0.03064507,-0.03196565,0.02405598,0.09805275,-0.03529223,0.006057825,0.009122664,-0.031962015,-0.019235484,0.068794675,-0.0018175615,-0.037408065,0.061032914,-0.036635228,-0.03532447,0.05053704,-0.02543479,-0.0021464701,-0.06884859,-0.030047666,-0.015444039,0.032374304,-0.009070554,0.013924627,0.08674896,-0.026709137,-0.0112844305,0.026633296,0.06418781,0.05142391,-0.04583844,-0.002739115,0.13016832,-0.049132317,-0.028643439,-0.027403215,0.030039543,-0.002918855,0.010733737,-0.0016907551,0.061085068,0.013584204,-0.016279312,-0.08744876,0.035795838,0.07002352,0.043401908,0.01386672,0.012754041,0.034062106,0.052215282,0.002644586,-0.14873452,-0.013028055,-0.018669907,-0.03378526,0.121951506,0.012473714,-0.017609784,0.021511786,0.023761991,0.071149565,-0.0015176984,-0.02998836,0.14737597,0.03353376,-0.07169627,-0.08162564,0.0173483,0.07423308,0.010249314,-0.0051331096,0.026787555,-0.013982444,-0.00990245,-0.12285078,1.2652781e-33,0.09490623,0.001028277,-0.025753383,0.008425658,0.026588872,0.009374974,-0.08766504,0.005754928,-0.023291718,0.016464751,-0.04728367,-0.08561424,0.058211327,-0.06373514,-0.049389843,-0.049944784,-0.010142518,-0.10689615,0.010320137,0.024794621,0.079090856,0.04396571,0.022802392,0.029435566,0.057405643,0.08454553,-0.0059590028,0.03563123,0.03166693,-0.03391252,0.08357477,-0.097346045,-0.15015057,0.014298641,0.09690892,0.0056108497,-0.055923004,-0.035036843,-0.043605037,0.052768435,-0.04938216,0.04271538,-0.027331967,-0.057325494,0.14395128,-0.08299427,-0.024524134,0.12355367,0.09614703,0.14592913,0.0038963216,-0.034784697,0.086127974,-0.0007615222,-0.050121266,0.066691935,0.02095715,0.021371145,-0.026650459,0.07004893,0.026798032,0.019468881,0.035209145,0.00571735,-0.049265016,0.023545159,-0.006171191,-0.03982619,-0.01822418,0.016423184,-0.004389366,0.059865333,0.09345722,-0.022904295,0.06566588,-0.06889933,-0.07386326,-0.062877536,0.06444489,-0.019955607,0.010155063,-0.013380727,-0.00010649154,-0.029908217,-0.04749315,-0.038278084,-0.04422689,0.036259968,-0.04031484,0.009246039,0.03715631,-0.09734067,-0.052613255,-0.0581944,0.018084094,-2.3698058e-33,0.04492337,-0.08422966,0.018069394,-0.06470188,-0.05405964,0.10139918,0.014929001,0.0022969693,-0.043837342,0.00626138,0.09515035,0.023099113,0.05209524,-0.046159666,0.06928852,0.03753434,-0.005674514,0.013279856,0.07509956,0.0026084522,-0.011469837,0.048062846,-0.00856809,-0.02243352,0.09305686,-0.006257297,-0.0111297015,0.029822592,0.09049706,0.060856137,-0.03974774,-0.07008105,-0.080610864,-0.07022078,0.029529156,0.044271473,-0.06856069,0.009309569,0.013521158,0.0043842015,0.0009990516,-0.008916968,-0.065144114,0.070592925,0.09525939,0.07786543,-0.16071203,-0.012549281,0.025510618,-0.04174064,-0.00512711,-0.017387692,-0.020105075,-0.029185286,0.028076306,-0.016481217,0.03668927,0.063061774,-0.03607014,-0.00090909074,-0.024027657,-0.11544158,-0.015978301,0.028175471,-0.009378609,0.033020318,-0.035058144,0.017005336,0.010751869,-0.03392556,0.040986244,-0.036999352,0.008398402,0.048519913,0.008137976,-0.0041937996,-0.027546924,-0.016505502,-0.00979716,0.016582398,0.039425705,0.042121395,0.012618462,-0.11079636,0.041708414,-0.06824195,-0.026824247,0.03417695,-0.03181196,-0.011949785,0.005830654,0.05789637,-0.004567793,0.0008689134,0.016375974,-3.052116e-08,0.029459387,-0.063944235,0.0063745473,-0.022655483,0.020343445,0.010358141,-0.013772768,-0.033128295,-0.030738093,-0.005541544,0.0014313118,0.057030555,0.0033824164,0.0004913874,0.027337788,0.029881429,-0.01787551,0.018926242,-0.07543234,0.002890352,-0.065525725,-0.00580117,-0.18688197,0.05544665,0.0376489,-0.0391749,-0.025690816,-0.047648,0.014165119,-0.07316215,-0.045045655,0.010619303,0.04152658,-0.039139412,-0.12847768,-0.019815983,-0.040934145,0.0005288244,-0.005872604,0.01763891,-0.008074177,-0.015343976,-0.03752144,-0.00073473336,0.015898608,0.025382638,0.044820335,0.010081619,-0.002130456,0.012193063,0.054887068,-0.011693027,0.0022674864,-0.086584695,-0.10138168,0.069471456,0.008539893,0.0035623757,0.004703944,-0.01513779,-0.036205094,-0.0011814868,0.081230536,-0.016401265 +1.2.1.94,"Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito). ",384,1.0,-0.04738671,0.023593167,-0.10290726,0.029001383,0.027279802,0.063524604,0.019347921,-0.043060824,-0.01820192,0.058317896,0.09573345,-0.067839496,-0.10067903,-0.004073863,-0.0060831206,0.11239693,-0.047873646,-0.027550388,0.018427607,-0.14718267,0.06536886,0.046581965,0.0012304572,-0.049844965,0.02317528,-0.02229452,-0.00844131,-0.02918964,-0.016627295,-0.07964821,-0.012068766,0.015029397,0.06995306,-0.015821606,-0.00078632624,0.024829661,-0.038888957,-0.07080082,0.068383574,0.0020798624,0.09677776,0.026686719,-0.0825703,-0.057661697,-0.06338094,-0.0068641645,0.0378624,0.027672812,0.066242985,-0.008116954,-0.009457967,-0.098254986,0.0050776373,0.059147295,-0.019834392,-0.020314759,0.0038462814,-0.078048036,-0.03336896,-0.019795282,-0.020070896,0.060759656,0.018267335,-0.0006836039,0.04730433,-0.04205579,0.001582725,-0.019833043,0.012502425,-0.081111915,-0.01579605,-0.04381373,-0.052361574,0.064815275,-0.018678911,0.0036186315,-0.020773526,-0.046463877,0.052016106,-0.044160184,-0.06583748,-0.024911946,0.04451386,0.08470121,-0.00078238023,-0.0017777646,0.011105358,0.03411873,0.008004287,0.070189774,0.0037699377,-0.063645095,-0.027434396,-0.0030545017,-0.0012024028,0.024555556,-0.030733343,-0.087203,0.008339969,-0.011618926,-0.008801848,0.02357601,-0.0448647,-0.060025617,-0.15636343,0.001826328,0.026037505,0.0010155187,0.050572377,0.034043014,-0.031729747,0.005559376,0.03335416,0.06271662,-0.015843648,-0.07249884,-0.051705148,0.0050023296,0.011879812,-0.008667591,0.032398865,0.037260715,0.00091934495,0.055368733,-0.012377659,0.029796032,-0.12886257,3.3670052e-33,0.07236969,0.013554172,0.022386707,-0.019236816,0.006649337,0.020778676,0.027462382,0.0726545,0.010060369,-0.10200897,-0.11684927,-0.10479984,-0.008803368,-0.017859684,0.028213635,0.024991892,0.048878103,-0.00799545,0.1100114,0.05951529,-0.041274704,0.048328772,-0.046398338,-0.108122945,0.0913947,0.10219952,-0.036359135,0.03218757,-0.0074114613,0.014296236,0.09961242,-0.04672035,-0.010056759,0.100492336,0.07434372,-0.0074593597,0.046177197,-0.045871474,-0.04920587,0.04213401,0.04714299,-0.059304386,0.02326451,-0.0053807427,-0.0013364275,-0.010595687,-0.08155873,0.035661686,0.10130018,0.076599106,-0.028445296,0.073437415,0.12534226,-0.08811421,-0.011785792,0.097816765,-0.0718241,-0.05071163,-0.044694856,0.009698912,-0.07682438,0.015131428,-0.028572012,-0.0065533477,0.0021212627,0.013184587,-0.028059253,-0.056797512,-0.01996567,0.04258376,-0.05634712,-0.02722106,-0.03966839,-0.061064325,0.0056391642,0.029378207,-0.03231073,-0.005720747,-0.025517154,-0.018048214,0.0115057025,-0.058968086,0.0141258165,-0.03214876,-0.023243349,0.006538923,0.034840155,-0.006681067,0.10968181,0.055025928,-0.00621047,-0.062414568,-0.0014963155,0.031474587,0.044226494,-5.0329298e-33,0.0076255137,-0.078907445,-0.0153736705,-0.050651502,-0.007211528,0.0634441,0.03111952,0.0055193277,-0.014413399,0.027738104,-0.005375405,0.010475155,-0.019304276,-0.123281054,0.050158884,-0.010892481,0.03195497,0.10232368,0.072873704,-0.043387473,-0.054686077,0.11895142,0.037083294,-0.04626561,0.0726063,-0.012452006,0.061770122,0.09039205,0.05140088,5.2949024e-05,0.02782529,0.003673206,0.046633188,-0.045255672,0.0038491695,-0.035279267,-0.05443682,-0.028993912,0.08589484,-0.0051240483,0.029125292,0.061834004,-0.029480647,-0.015970435,0.04147683,0.04092904,-0.07561217,0.028360534,0.02545997,-0.022177467,0.017973308,-0.0557594,0.008712739,-0.05173524,0.00033078287,-2.6501084e-06,0.016183438,-0.014862817,0.044376504,-0.062187936,-0.02383186,-0.10403788,0.032568406,0.041045252,-0.062577724,0.038183104,0.03199894,0.032800086,-0.002698785,0.038791478,0.055209387,-0.06209453,0.012759397,0.06253863,-0.09984339,-0.041186687,-0.019003354,-0.022474961,0.04290936,-0.028329823,0.030897828,0.0066869077,-0.02780844,-0.083923504,-0.020056546,-0.061215684,-0.018378487,0.060555253,-0.0059954617,0.0378225,-0.05840891,-0.013834178,-0.07619735,0.053933132,0.013245067,-3.5385284e-08,0.051923383,-0.024176769,0.04570645,-0.019381886,0.037589185,-0.028791651,0.028467942,-0.022943959,0.07776766,-0.016669046,-0.026198652,0.017331809,0.10685265,0.02121525,0.10081318,0.00070253504,0.02884872,0.049380045,-0.024732232,-0.07659923,-0.03265065,0.06846231,-0.08846198,0.03625337,-0.04591377,-0.047069483,0.0074597956,0.038197435,0.015195544,0.012569996,-0.03991659,0.10085072,0.07262838,-0.061295383,-0.051212415,0.030418456,0.0045033097,-0.07290724,0.06012038,-0.026369149,0.011327627,-0.00019319564,0.045463793,-0.03955773,0.01401762,-0.05641423,0.080528766,-0.00030762807,-0.03481381,0.013697413,0.02182454,0.050207067,-0.012786462,-0.051489186,-0.082619056,-0.041379075,-0.03416582,-0.15780327,-0.06124,-0.03018857,0.062255096,0.023583584,0.14089027,-0.033407055 +1.2.1.95,"This enzyme, characterized from the yeast Saccharomyces cerevisiae, catalyses the reduction of L-2-aminoadipate to (S)-2-amino-6-oxohexanoate during L-lysine biosynthesis. An adenylation domain activates the substrate at the expense of ATP hydrolysis, and forms L-2-aminoadipate adenylate, which is attached to a peptidyl-carrier protein (PCP) domain. Binding of NADPH results in reductive cleavage of the acyl-S-enzyme intermediate, releasing (S)-2-amino-6-oxohexanoate. Different from EC 1.2.1.31, L-aminoadipate-semialdehyde dehydrogenase, which catalyses a similar transformation in the opposite direction without ATP hydrolysis.",384,0.99999994,-0.007159366,-0.06542949,0.01433159,-0.03178794,0.08616673,0.058351576,-0.09750451,0.023990659,0.06970683,0.044019956,0.012600243,0.0013313162,-0.054074146,0.008429253,-0.011648174,0.045857042,-0.06761649,-0.031968374,0.035836257,-0.045065667,0.08892622,0.022655157,-0.0109992325,0.009905095,0.10529277,-0.022591094,0.046233844,0.007631306,-0.04221629,-0.04413475,0.0038922003,-0.08697322,-0.016607342,-0.02328023,0.03451973,0.090762444,-0.035945904,-0.012430972,0.03189662,-0.0040928214,-0.0044573704,-0.06787832,-0.0941037,-0.0039433986,-0.054611493,-0.003565861,0.012966457,0.08150598,0.005698482,-0.010444658,-0.0061029955,-0.037830368,-0.008813884,-0.03367107,-0.07380077,0.03295471,-0.035961684,0.0017004096,-0.011172145,-0.014944916,-0.04277158,-0.049126573,-0.030893927,0.039332718,0.027302312,-0.104467176,0.07235533,-0.054213088,0.010915365,-0.032676246,-0.104341365,-0.08457589,0.004216994,0.035887644,0.04662449,0.006618834,-0.012112046,-0.04376975,0.0432377,-0.030598715,0.10297976,0.028818455,0.040286478,0.04135422,0.051689643,-0.03612034,0.021492194,0.009501467,0.045698114,-0.02566188,-0.013093123,-0.029638434,0.033844735,0.031904556,-0.03911748,0.04089309,0.07992266,0.03684422,-0.040101226,0.009618143,0.044777803,0.15424444,-0.026097283,-0.08799362,0.031164328,0.03548211,-0.07832248,0.12859075,-0.024176406,-0.056771908,0.04487897,0.007247285,-0.006704537,0.0057624914,0.01744318,0.13241178,0.0036556688,-0.017920965,-0.050930418,-0.08130459,-0.016426422,0.01382754,0.01879623,0.051884107,-0.059281774,0.00357175,-0.10406125,2.4380544e-33,0.053467955,0.017759187,-0.061983947,-0.0064973906,0.031345252,-0.043404695,-0.099367976,0.046453338,0.02092971,0.041337676,-0.05314417,-0.033738963,0.039299577,-0.03969548,-0.027075317,-0.026439395,-0.011735975,0.020681622,0.05695405,0.05960355,-0.057198152,0.0130327605,0.006870472,0.015560786,0.029134486,-0.005074179,-0.053422462,0.02615388,0.010486543,0.020249326,-0.04613737,-0.097832285,-0.0796908,-0.016651453,0.029142518,-0.07126879,-0.034515873,-0.08624885,0.067752935,0.013099577,-0.032291543,0.03875914,-0.021707566,-0.011590869,0.026970752,-0.027683223,0.041707512,0.07220864,-0.013931216,0.045362182,0.084699735,-0.052581772,0.15095156,-0.05909296,-0.05341927,-0.004132909,-0.04802111,-0.03251239,0.030217804,0.06447872,0.0014489135,0.071792975,0.024440525,0.05111116,-0.027987022,-0.06889204,-0.06568866,-0.08079884,-0.002685595,0.08769727,-0.07232824,0.04171988,0.13984466,0.01090205,0.057847507,-0.06902429,-0.030420817,0.026423289,0.008927369,0.04424698,0.04128753,0.014814428,-0.023974242,-0.020122206,0.030237768,-0.022151612,0.013261731,-0.08821505,-0.0358175,-0.021785684,0.019331237,-0.029998824,-0.0021691236,0.036141455,0.07615843,-3.640279e-33,0.13401021,-0.075227864,-0.013279415,-0.08915603,-0.081380464,0.058668375,0.07781653,-0.05186252,-0.036711283,-0.080507234,0.053027403,0.019513085,0.0008147491,-0.04416307,0.08835928,-0.05771992,0.0030975803,0.03619803,-0.056453064,0.0048883464,0.018204952,0.077798545,0.012004053,0.015195464,0.089758545,-0.016911224,-0.041198444,0.065713264,0.060814064,0.019875167,-0.044353943,-0.012090397,-0.015374145,-0.017871143,-0.009813484,0.06819525,-0.09257688,0.02862713,0.0052180127,0.07764183,0.057277385,0.05959879,-0.08436699,0.03432993,0.044339478,0.0457948,-0.044621166,0.02049298,0.020188343,-0.12559882,0.026798883,-0.024220672,-0.04476705,0.018816138,0.06829928,0.041121464,-0.0155341895,-0.0113506,-0.009088508,0.015563811,-0.062845975,-0.058548898,0.0018287668,0.041493475,0.020096887,0.009098629,-0.056641307,0.042702798,-0.0037233366,0.040147558,0.058106277,0.013652811,0.015333313,0.02908115,0.0066557718,0.009610979,-0.040437493,-0.071710944,-0.08167346,-0.062030993,0.006063002,-0.0007593332,0.020450504,-0.045365267,-0.0064082807,-0.05328701,0.006651929,0.10548305,-0.031666163,0.048456073,0.06762898,-0.017085789,-0.02832112,0.079873435,0.084143706,-4.5379267e-08,0.024506995,0.019306248,0.098567195,-0.053375565,0.039473202,0.060199983,0.024387663,-0.02016421,0.01767331,-0.085017964,-0.06297481,0.089768164,0.030653268,0.041971624,0.020597538,0.03195259,-0.04293888,0.10978239,-0.025309434,0.0025950652,-0.054077446,-0.042571384,-0.10029275,0.01896571,0.034560576,-0.050487813,-0.021816691,0.0013928433,0.040432286,-0.060202345,0.015484931,0.0004150976,0.020779138,-0.02991182,-0.023557473,0.00083217915,-0.06925957,-0.035105262,-0.030210331,-0.008444488,-0.029268913,-0.020567521,-0.026923735,0.054051016,0.017636528,0.06608462,0.04821955,0.014838915,-0.028525863,0.0071429657,0.042275634,-0.030701108,-0.023762325,-0.06881328,-0.04039859,-0.008254329,-0.09721283,-0.07442266,-0.0018522138,-0.11517962,-0.014066654,0.059794623,0.14919588,-0.080056034 +1.3.7.11,"A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4].",384,1.0,-0.059831165,0.0037293355,-0.12743023,-0.0012764093,0.06480965,0.025359534,-0.05392165,0.009940296,0.074148886,-0.0679347,-0.021306906,0.029392155,-0.093480796,0.020601084,-0.046806976,-0.021948786,-0.03156951,0.005084136,-0.025090927,-0.0018567248,0.03946725,6.257905e-05,0.0261405,0.021825932,0.0126289865,0.010443796,0.02819483,-0.08910975,-0.09519724,-0.02173012,0.043453757,-0.059774145,0.118449904,-0.045055825,-0.017526122,0.07494178,0.005042991,0.042427357,-0.013117016,-0.010393803,0.038586047,-0.024437115,0.046764947,-0.028329019,0.015613925,0.0037229327,-0.027084796,0.010512758,0.03229851,0.028124038,-0.04757235,-0.030720845,-0.10238758,0.0019067659,0.04384186,0.04923082,-0.059755582,-0.04781943,-0.03620543,-0.017292492,0.04595077,-0.05448882,0.059455678,0.038325265,-0.0530999,-0.08101328,0.0655672,-0.044890925,0.060285978,0.0022009742,-0.019228632,0.0030771773,-0.033697143,-0.021729078,-0.024089593,0.09605923,-0.028333137,0.028146828,0.07810887,-0.040412676,0.06778153,-0.077558555,-0.012257166,0.1055546,0.039924745,-0.023492485,-0.04163926,-0.015782505,-0.004706263,0.05131247,0.04194147,-0.008868048,0.0645242,0.015285059,-0.11249447,0.03389436,0.04892365,-0.056642972,-0.096034825,-0.013154963,-0.0049260855,0.036304493,0.043845598,-0.077325806,-0.038963348,0.0011016828,-0.06872825,0.07939701,-0.024761645,-0.0120685,0.021350449,-0.03590029,0.09675944,-0.027248539,-0.010260903,0.06706606,-0.013733859,-0.048521638,-0.08079662,0.05965657,-0.047829967,0.025577514,0.06500318,0.043756213,0.012404465,0.02127465,-0.10407707,5.2440816e-33,0.09385375,0.033379085,-0.021725764,-0.0034760027,0.01679499,-0.008655719,-0.07736112,0.024528908,-0.007812811,-0.003784526,-0.022226084,-0.079230934,0.041136805,-0.004591569,-0.0045682406,0.019128421,0.0074585527,-0.027266052,0.09514018,-0.06711207,-0.005165651,0.04283186,0.029543757,-0.025767067,0.09319349,-0.007632024,-0.0477887,-0.020604013,0.03287228,0.015910372,0.03240935,-0.1421417,-0.106012516,0.02293913,0.073024675,0.029225493,-0.08391182,-0.077993445,-0.074889995,0.051683728,-0.07891046,0.015749464,-0.022663843,-0.046118826,0.06873051,-0.012236623,-0.0967984,0.12862466,0.06075882,0.10984251,0.025532357,-0.051002223,0.093508795,0.10458728,-0.088533126,0.00076599256,-0.022848139,0.030811971,0.0014183725,0.0518974,0.037411973,0.09047831,-0.04181518,-0.0022262437,0.0147540085,0.05242152,-0.061249748,-0.03040933,-0.030664017,0.06777358,0.09626522,0.0035129392,0.07841179,0.052666266,0.022270693,-0.028783247,0.022894062,-0.031783767,0.0004187466,0.04143621,-0.0024751327,0.010203962,0.022763958,-0.012110022,-0.038973544,0.065985605,-0.031825833,-0.040277135,0.01886578,0.043372404,0.011091081,-0.05231975,0.00022811699,0.011003303,-0.034545034,-4.1033804e-33,0.055876486,-0.1279725,0.070964366,-0.050969373,-0.0075734654,0.08830063,0.0016969148,-0.035112936,0.03404759,-0.086702295,0.02478955,-0.010086615,0.04600602,-0.013196277,0.0241296,-0.0049019917,-0.020999117,0.02070432,0.048978418,0.004596075,-0.011742956,0.025862236,0.004870169,0.105374746,0.021806823,-0.040454406,0.004919763,0.010347348,0.0057584583,0.07832024,0.008304285,0.0041400017,-0.11376586,-0.04309744,-0.07411044,0.038041204,-0.04405444,0.057653844,0.003984131,0.015844705,-0.0005496697,0.026187832,0.020093197,-0.038731337,0.08360393,0.07008398,-0.083464,0.0770176,0.04200055,-0.05530062,-0.021607717,2.0283132e-05,-0.030814908,0.07319634,0.08522452,0.03980217,0.07112275,0.06200435,0.01239889,-0.058278136,-0.05245741,-0.11515825,0.017079439,-0.00029940082,0.07068627,0.14572355,0.033517227,0.055870987,-0.0076198233,-0.017093023,0.0649081,-0.01814911,0.0077963956,0.07196262,0.047638807,0.011080319,-0.03179599,-0.02078809,0.010350974,-0.00344684,0.051140472,-0.010779381,0.036709473,-0.0650707,-0.015259931,-0.082885034,0.049957488,0.057081155,0.004231218,0.035840902,-0.010900176,0.029093932,-0.044547204,-0.03889587,0.057863034,-4.6983626e-08,0.060164206,-0.03638992,0.025749465,-0.07407719,0.020678151,0.03511669,0.05861284,-0.019123187,-0.018715499,-0.08007836,-0.030190751,0.10724653,-0.00140699,-0.03389885,0.024477677,0.00898676,-0.041902393,0.03632494,-0.025431557,-0.08614143,-0.03164579,0.0090541495,-0.13553277,0.036740478,0.004039369,-0.054123282,0.008207138,-0.022276122,0.045132846,-0.049337175,0.021991504,-0.012213923,0.03940535,0.012337026,-0.043250434,-0.03632571,-0.042681295,-0.031007944,-0.042872,0.08626173,-0.08138543,-0.013190337,-0.0065613235,-0.0024389003,-0.003313827,-0.010783889,0.04103946,0.03333473,-0.090614304,0.020627141,0.027653106,0.024076732,0.029650027,-0.06619004,-0.110161684,-0.038362738,0.027447663,-0.051678892,-0.056317743,-0.021907171,0.026018916,-0.028248135,0.11048291,0.014825303 +1.3.99.37,"The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the desaturation of the C-3,4 double bond in dihydroisopentenyldehydrorhodopin and the desaturation of the C-3',4' double bond in dihydrobisanhydrobacterioruberin. ",384,1.0,-0.10782935,0.0016465525,-0.1152879,-0.03139156,-0.017679218,0.049364824,-0.11481323,0.05107507,0.01784279,-0.03983697,0.030967118,-0.077938445,-0.04121737,0.025764948,-0.016634768,0.01792633,-0.09450785,0.041712284,-0.06655113,-0.051330872,0.0036562386,-0.038490742,-0.040828746,0.023551725,0.06753062,0.036613222,0.04083179,-0.04889365,-0.012924664,-0.030495258,-0.02440498,-0.038584597,0.11832964,-0.048996773,0.13831736,0.014650204,-0.033354715,-0.12123366,0.07429399,0.016722878,0.020465456,0.05225997,0.005306381,0.008506577,-0.021327708,0.047865886,-0.078026965,0.065878786,0.04326145,-0.022278817,-0.074953884,-0.033461876,0.003081952,-0.062638074,0.0016229475,0.049130592,0.0018938575,-0.034111302,0.060136367,0.030584471,0.08103518,0.01994353,0.059111807,-0.023389926,0.0051952885,-0.11344297,0.015687605,-0.051702745,0.05655044,-0.070291184,-0.048229888,-0.08195279,-0.0057299114,-0.031850312,0.015046498,0.031264707,-0.028188668,-0.027639408,-0.03293269,-0.09246634,0.07614936,-0.044003412,0.05304617,0.030580029,0.0055082487,-0.039755657,-0.0024036996,-0.005523411,0.024627842,0.110434495,0.0031627188,-0.008424864,-0.05684215,-0.042744767,-0.11448621,0.055503104,0.07356161,-0.02294334,-0.04455025,0.0011786224,0.016541593,0.058292456,0.0015241953,-0.09086931,-0.03676498,-0.035078652,-0.03184105,0.061889738,0.00817105,-0.02285805,0.05695618,0.014318011,0.043496255,-0.031250097,-0.017684467,0.05795385,0.015426318,-0.008965714,-0.05740962,0.027032517,0.06476069,-0.078444816,0.06865187,-0.010066024,-0.06303096,0.024049997,-0.12275445,4.939251e-33,0.09399073,0.030286936,-0.008126601,0.018010495,-0.0010113149,-0.07766944,-0.101760834,0.04888875,-0.08428773,-0.1295977,-0.090868376,-0.033239692,0.053496625,-0.06551232,-0.07656547,0.012125161,-0.022630211,-0.009055129,0.008482256,0.01296078,0.024865557,0.06349909,-0.015538282,0.021802498,0.079423316,0.031656563,-0.013333407,0.008605968,0.03665669,0.01471243,0.06189725,-0.04778077,-0.06287247,-0.0022938664,0.16424832,-0.0123100765,0.00083285343,-0.06872614,-0.110317945,0.057925794,-0.011657108,0.019308323,-0.021401377,0.021609403,0.022001395,-0.011494254,0.043974023,0.03392289,0.036918275,0.035653405,-0.0011219091,0.023452714,0.075108945,-0.045511924,-0.027415242,0.064561486,0.015917838,-0.03504125,0.049180027,0.0047863415,-0.0022505743,0.087305374,-0.05434942,-0.0029156143,0.014263504,-0.010969875,-0.07392895,-0.014325144,0.016693788,0.048411384,-0.051690225,-0.05911529,0.04098875,0.039988834,0.030881183,-0.022776002,-0.038728017,-0.0062663965,0.01890753,-0.12764604,-0.02557781,0.037186332,0.0960799,-0.051249243,0.001983434,0.0308189,-0.065668695,-0.047062505,0.015712231,0.0696957,0.0068948553,-0.04526804,-0.002853634,-0.016892223,0.030303748,-5.2673832e-33,0.10507215,-0.11262646,-0.042493355,-0.0060155718,-0.054008525,0.06369789,-0.043868817,-0.091377005,-0.008245691,-0.03996959,0.10777621,0.029492393,0.08392438,-0.012361473,0.03114177,0.051777408,0.09811302,0.080036454,-0.08675288,0.0036177675,0.055860825,0.010343122,0.034338538,0.017015852,-0.02743612,0.019871542,-0.009954829,-0.013608474,0.06586458,0.035238504,-0.003634843,-0.011952828,-0.040489785,-0.08220258,-0.048744284,0.057961855,-0.07066152,-0.030147543,0.01628887,0.06126147,-0.07063814,0.030089663,0.00048653377,0.01629001,0.019360764,0.03425002,-0.023000767,0.022357136,0.039043475,-0.021724112,0.035215348,-0.072712086,0.011848483,0.04690964,0.0036183086,-0.009381804,0.097682096,0.03388595,-0.008818132,0.015967166,-0.0048852945,-0.07019752,0.044367585,-0.027260168,0.06995304,0.0077303797,-0.015438029,0.116209,0.08469656,-0.091172054,0.050168402,0.019727657,0.049916998,0.056068983,-0.030636486,0.003821075,-0.018012503,-0.059212737,0.04760611,-0.03423618,-0.031595424,0.05047987,0.036546476,-0.048110764,-0.05426494,-0.09861575,0.043815568,0.05094143,-0.027106993,0.018682245,-0.016631799,0.029229013,-0.018624786,0.04714333,0.06628832,-3.9854807e-08,-0.010821557,0.0013382013,0.022985158,-0.056869347,0.07504584,-0.0075193415,-0.03641903,-0.0055679926,0.073305294,-0.06568277,-0.015539714,0.04876499,0.057787057,-0.007813456,0.004919178,0.056002345,-0.006917955,-0.0113482345,-0.020503346,0.08524538,-0.044072963,0.014366161,-0.084944196,-0.009479555,0.014118151,-0.056324247,0.00901453,0.019012153,0.002696336,0.01085337,-0.020590052,0.008068677,0.023000436,-0.050175015,-0.058037348,0.024628699,-0.012094015,-0.03326332,-0.0612175,-0.003771292,0.037600927,-0.05610049,-0.07257421,0.050022714,-0.04261964,0.018047549,0.005313614,0.069223374,-0.09087864,0.027685495,0.03548566,-0.02972467,0.017614817,0.011879397,-0.059690278,-0.0045323777,0.071751185,-0.03472409,0.0028488932,-0.042141106,-0.0049758176,0.030643212,0.15428153,0.0117780445 +1.4.99.6,"Contains a non-covalent FAD cofactor. The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.1.25, L-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine. The enzyme has a broad substrate range and can act on most D-amino acids with the exception of D-glutamate and D-aspartate. However, activity is maximal with D-arginine and D-lysine. Not active on glycine.",384,1.0,-0.08082645,-0.13100551,-0.09012663,-0.090791956,0.049222514,0.057002492,-0.0656303,0.048444845,-0.007906601,0.04956468,0.011376078,0.012809933,-0.067805976,0.07183526,-0.038407095,0.025183361,-0.048168972,-0.06123793,0.005625601,-0.012513835,0.026301248,0.11214658,-0.09607636,-0.049062192,0.06065278,0.004066961,0.077660486,-0.010869589,0.007953427,-0.026178876,0.0098810885,-0.09923431,0.06700565,-0.030442443,0.04073004,0.058692385,-0.010774533,-0.018669987,0.12263036,0.020492278,0.029372336,0.01916409,-0.0074422876,-0.10469106,-0.010268969,0.01702178,-0.0030830367,0.039337292,0.03447233,-0.018526984,0.003896294,-0.047471263,0.002946611,0.004194212,-0.03399525,0.046748593,-0.05244792,-0.03070918,-0.022795033,-0.020041395,-0.005504668,0.019073308,0.049941,0.026623033,0.0034861309,-0.049221605,0.05134916,-0.052746505,0.090284795,-0.055981684,-0.0019424751,-0.05627837,0.014120596,0.015972275,-0.0066370657,-0.0420576,-0.038429845,-0.07489562,0.059428517,-0.097206905,0.044661757,-0.030903047,0.070495,0.07182113,0.015234655,-0.05145387,-8.198176e-05,0.044627495,0.073636964,-0.007004552,0.024233935,-0.010139495,-0.027836394,-0.056294326,-0.028098138,0.024030173,0.015354938,0.045129415,-0.048027255,-0.044612292,0.0015847131,0.08964371,-0.03761881,-0.02261806,-0.015277486,-0.019347498,0.026691811,0.04413173,-0.040317148,-0.036131155,-0.0033045607,0.0047771325,0.020650452,0.010038453,-0.062110633,0.0096047,0.08872576,-0.09082728,-0.07135318,-0.011641947,0.0063345353,-0.04414223,0.107262306,0.101791404,0.0212778,0.05497474,-0.07361683,5.6177187e-34,0.046728294,-0.032394286,-0.0116002215,-0.082686365,0.0051126922,0.0056606797,-0.109470144,0.042939167,0.029021516,-0.021289732,-0.06845304,-0.014456708,0.06898724,0.044416647,0.02241257,0.050877415,-0.008874863,-0.030762222,0.05754153,-0.023527805,0.059819836,0.08234922,-0.014270627,0.049931765,0.046349354,0.011511876,0.08104663,0.061548635,-0.011947581,0.02110592,-0.079809286,-0.13355668,-0.065772526,0.010872515,0.046172727,0.023780117,-0.08190519,0.004580585,0.061274234,0.054651164,0.023742475,0.014053255,0.0018006667,-0.051356297,0.007981943,-0.01580032,-0.059303142,0.08566733,-0.060125995,0.07566156,0.06354785,-0.07903079,0.045426548,-0.043114506,-0.06361334,-0.025154471,-0.047980994,0.0056721685,0.10653447,0.08237729,0.022603048,0.04198317,-0.026554102,0.09106099,-0.023247309,-0.019946449,-0.05545908,-0.0919269,0.009611205,0.06116203,-0.052743517,-0.08716643,0.09519661,-0.028936377,0.018870141,-0.09819712,0.022694616,0.021313109,0.023462141,-0.019019052,-0.009143028,0.003186956,0.019637963,-0.010205104,-0.04203707,-0.023427501,-0.01489568,-0.076078594,-0.0150703415,-0.02487449,3.4048375e-05,-0.042988803,-0.065008305,0.04728064,0.06461802,-2.133915e-33,0.04084275,-0.08354115,0.06673883,-0.06554759,-0.06739982,0.11170614,0.075821176,0.049308315,0.07973542,-0.03694802,0.04474117,0.04700864,-0.018494375,-0.0036577757,0.03870609,0.05169642,-0.01693415,0.016546044,-0.009616269,-0.029723901,-0.014235058,0.03257401,0.019571021,0.009662219,0.053380482,0.023124248,-0.06383563,0.035692446,-0.007240702,0.075686105,-0.0042942916,0.012931265,-0.037316173,-0.045719046,-0.074172266,0.06661526,0.0031937656,-0.0001372647,-0.042793665,-0.04729637,0.02472869,0.03166957,0.03136444,0.08192348,0.024788525,0.020558389,-0.027268825,-0.06570864,-0.06496257,-0.1121821,0.03191267,-0.057631116,0.0748311,-0.0074698045,0.011350211,0.0064047542,0.043833215,0.07527368,-0.11480699,0.026026338,0.03631391,-0.09371638,-0.0342658,0.020665029,0.065696515,-0.0036361082,0.018505039,0.059015173,0.007320389,-0.020535009,0.082312375,0.03979997,0.018231768,0.06261995,-0.03358392,-0.0064925975,-0.050735336,-0.02601593,0.05483196,0.021115864,0.020446502,0.0041842717,-0.061971556,0.001484335,-0.07930372,-0.061490715,-0.0020107483,0.14680351,-0.0013582599,0.033587057,-0.046237145,0.009178937,-0.017197097,0.05544312,0.076518714,-4.206447e-08,0.071546525,-0.00534838,0.063814946,-0.0128113385,-0.0043080305,0.052343745,-0.03250197,-0.02524188,0.028861962,-0.03591006,-0.00660493,0.049767338,-0.03912883,0.0028880585,0.013942507,0.04497037,-0.1217622,0.025343468,-0.038155153,0.06372113,-0.026204998,0.02118345,-0.13116181,-0.018524043,-0.03061978,-0.031175582,0.051555872,-0.007847755,-0.03670789,-0.00044773446,-0.04187828,0.012143254,-0.04051208,-0.039098345,-0.09353986,-0.011887787,0.0042465767,-0.020672992,-0.04745599,0.011508582,-0.015271697,0.03465847,-0.07028966,0.01244456,0.013557332,0.031901844,-0.01734682,-0.0318477,-0.02588955,-0.010117248,0.03689716,-0.023556441,0.04192527,-0.048940994,-0.11875799,-0.012906271,-0.105323784,-0.109482236,-0.0105446745,-0.054310255,0.0415863,0.01611459,0.11085614,0.07458974 +1.5.1.50,"The enzyme, found in many Gram negative bacteria, also slowly reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). The enzyme has no activity with NADH.",384,1.0,-0.051658303,0.011928107,-0.044206616,-0.034149244,0.04592749,0.032919228,-0.09633128,0.08464058,0.020136863,0.016914222,0.008526066,0.0044584554,-0.067301996,0.07544736,-0.041855972,0.0022926896,-0.037974317,0.03051525,-0.020884356,-0.06402404,0.036107805,0.0063381954,-0.003620467,-0.011633677,0.05442698,-0.016768433,-0.0004048699,-0.013938877,-0.01666081,-0.07905199,-0.040590473,0.03639878,0.032903153,-0.043610934,0.057958387,0.12618802,-0.032623343,-0.005209541,0.019272646,0.082723476,-0.0039719935,-0.024536503,-0.05524474,-0.029178869,-0.050077043,-0.02363061,0.013172227,0.080531806,0.076259986,-0.025330832,-0.10794474,-0.0033040137,-0.038755935,0.051690355,0.059287667,-0.02677239,0.030343765,-0.010360788,-0.07980679,-0.010357104,0.03733837,-0.059944343,-0.04030589,-0.0063980655,0.025402792,-0.013689593,0.06481454,-0.093057685,-0.04565357,0.0001264464,-0.06351057,0.00015488741,0.061196636,0.062918045,-0.0492386,0.042911705,-0.02218238,-0.07338717,0.058370214,-0.01602957,0.08443254,0.0074641537,-0.022076614,0.044581838,0.030595444,-0.04683855,-0.029487126,-0.016964948,0.02537477,0.0065699075,0.04743439,0.0077125323,-0.043791674,-0.062377416,-0.15232986,0.042296544,-0.007632372,0.024791341,-0.009207159,-0.013947637,0.023607872,0.10492753,-0.048137106,-0.053197615,-0.0728873,0.057742886,-0.013921341,0.11061441,-0.062564455,0.0089353,0.0053896233,0.010913351,0.018827938,-0.011327031,-0.07502884,0.09233673,0.056309618,-0.033639356,-0.1458034,-0.007376999,-0.0090889605,0.0053196717,0.097848356,0.055268984,-0.017823694,0.048650797,-0.096514456,7.0669605e-34,0.057327602,0.01590241,0.0031099953,-0.025501681,0.045339853,0.01588202,-0.104631655,0.070532836,0.0140935285,-0.03461239,0.015336503,-0.062338997,0.054368377,-0.048394267,0.032140497,-0.0041198283,0.037545826,-0.05829926,-0.03488519,0.012937064,0.03680266,0.023518628,-0.037683934,0.011411023,0.04405592,0.055773433,-0.023697332,0.041959472,-0.0026396906,-0.018901011,-0.0015938159,-0.10508239,-0.08874561,0.007388665,0.12773435,-0.039844368,-0.07907531,-0.011194531,-0.00494089,0.03468475,-0.036956564,0.06679061,0.0028760773,-0.022512425,0.069277965,-0.09197364,0.040916983,0.06034596,0.04078725,0.06627985,0.122278854,-0.005626252,0.04313171,-0.06101312,-0.053267878,0.03387099,-0.00036449477,0.008542908,0.03626376,0.06768047,0.0427655,-0.014452655,-0.06458325,0.01317301,-0.019251563,0.01658177,-0.07369883,-0.10508403,-0.005045021,0.07012806,-0.049398478,0.038012084,0.0659803,0.01966023,0.03424374,-0.03728611,0.013911007,-0.007558869,0.06258325,-0.087549664,0.0083310725,-0.019074596,-0.01020499,-0.017967723,-0.045889124,0.0243776,0.008808978,-0.03844563,0.002784503,-0.039822668,0.11071022,-0.10401279,-0.076308824,-0.06346568,0.032951605,-1.9524491e-33,0.06514351,-0.053044237,0.014087313,-0.110208705,-0.032221243,0.124692544,0.08788593,-0.010449146,0.014725868,-0.069540925,0.08802184,0.055480305,0.016790286,-0.0050119106,0.038012393,0.042680863,0.003140624,0.056273095,-0.027900986,-0.041894425,0.002098927,0.12613833,0.03732209,-0.003890231,0.04532657,-0.038335502,-0.05525358,0.08177768,0.072871044,0.021738308,-0.0015440243,0.016124656,-0.049114645,-0.026434176,-0.013639989,0.060867026,-0.11193155,-0.009689646,-0.014401657,0.051092148,0.009961913,-0.012149678,-0.014042701,-0.02410329,-0.0018841341,0.082138315,-0.12555352,-0.01650865,0.048200272,-0.03134119,0.057322837,0.017822798,-0.050994385,0.026188908,0.06323138,0.024156416,-0.009450721,-0.016349724,0.030173343,0.014679219,-0.02125574,-0.058329742,0.024392854,-0.00064656837,0.039843198,0.035049025,0.00536851,0.072828926,0.06306526,-0.040641267,0.075396925,0.03904862,-0.008854809,0.031200895,-0.044680465,-0.04742757,-0.059968054,0.014950165,-0.03936423,0.009439887,-0.0137676755,0.009655299,-0.056647405,-0.07449028,-0.01130484,-0.037073564,0.031671505,0.03141941,-0.008761504,0.10228809,0.008635521,0.023621624,-0.0076808063,0.03849334,0.036102686,-3.637306e-08,0.03528532,-0.07109922,0.03809858,-0.059811253,0.06411288,-0.008536608,0.01867333,0.017892146,0.051391546,0.008581804,-0.00030937095,0.10464561,0.03386007,0.06226797,0.010842897,0.012808218,-0.041638713,-0.04686397,-0.028494343,-0.01775352,-0.03883279,-0.012640071,-0.1275648,0.050603587,0.029684993,-0.04631887,0.022471497,0.00050908694,-0.04658523,-0.10641025,0.016342547,0.05571727,0.038724095,-0.021065634,-0.09306495,0.036010303,-0.043477297,0.04950214,-0.06356628,0.07803171,-0.00998717,-0.05748528,-0.08786923,0.043691542,-0.0015520836,0.004531053,0.0026338329,-0.015946774,-0.0071037416,0.020132484,0.07656454,0.05667301,-0.02763833,-0.04157241,-0.087405406,-0.02617681,-0.019511357,-0.060469043,-0.041094523,-0.07331706,0.04114515,-0.030518476,0.14311175,-0.042538136 +1.6.1.4,"The iron-sulfur flavoprotein complex, originally isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH.",384,1.0,-0.08743866,0.05262652,-0.13066697,0.07379199,0.10514714,0.038378913,-0.046625283,0.0013942731,0.038771167,-0.049971357,0.013245094,0.042836837,-0.03610607,0.031292148,-0.062217005,0.0021467968,-0.024491122,0.032491103,0.004132592,0.0782839,-0.021311529,0.026436327,0.065373145,-0.031458393,-0.01903613,0.07736718,0.058357064,0.006511999,-0.043293525,-0.043068197,0.0085788425,0.0078019598,0.029499022,-0.077352606,-0.00013102192,0.05889048,-0.013448188,0.031202368,0.04200493,-0.049907953,-0.012382745,0.017457737,-0.007606591,-0.04754919,-0.015496429,-0.006383241,-0.016111944,0.061256167,0.026211439,0.00088648585,-0.019936088,-0.012017512,-0.04860899,0.05379452,0.08199876,-0.037907083,-0.023665853,-0.036927246,-0.021514557,-0.02365174,0.056246966,-0.0561265,0.00928925,-0.009316525,-0.0067171305,-0.049650352,0.08630945,-0.018417282,0.018777812,-0.06927334,-0.041122492,0.037076637,-0.052907944,0.06359402,0.011266758,0.11990324,-0.03248224,-0.017911892,0.067987956,0.022872828,0.046340447,-0.0043362156,0.005255761,0.103204764,0.031115131,-0.025372284,-0.028910635,0.03209986,-0.02603406,0.019686313,0.0019832011,0.005115926,-0.00037206372,-0.0054269047,-0.046466585,0.020253854,0.021351187,0.054528523,-0.031018596,-0.000348034,-0.02973556,-0.00049377006,0.025440564,-0.115753576,-0.05875234,-0.05321051,0.011623051,0.11723387,-0.017752988,-0.021180542,-0.018118028,-0.057253852,0.022566983,-0.07072033,0.062920816,0.088885486,0.075675406,0.0051705115,-0.06504971,0.01274182,0.021590523,0.09322426,0.030286485,0.0451917,0.020762438,0.046559844,-0.11289018,3.626067e-33,0.09958901,0.06377583,0.02553566,-0.0016695233,0.064346105,-0.016066115,-0.06322951,0.0026382734,0.031246945,0.019691959,-0.0668979,-0.06797787,0.05688898,-0.10097051,0.009503761,-0.023510437,-0.06825067,-0.04479262,0.05604092,-0.049141463,0.058742933,0.11256898,0.05890495,0.021032408,0.00509906,0.070199154,-0.04876636,-0.022185048,-0.02309316,-0.014717524,0.07811148,-0.08012889,-0.1474573,-0.01521231,0.11461461,0.028433902,-0.06395331,-0.107651226,-0.06982448,0.034826893,-0.03981187,0.039573014,-0.039686438,-0.019250002,0.048536893,-0.079539455,-0.0917687,0.088514864,0.0147947,0.060222015,0.016568208,-0.03848268,0.06890595,0.0018867549,-0.119434856,0.05678093,0.01710342,0.01559114,0.021962518,0.054974865,0.01540282,0.072852485,0.00061156217,0.056355063,-0.027647534,-0.0041080653,-0.081339955,-0.022207273,-0.022881478,0.029666783,0.034897808,0.042624004,0.05734735,-0.01282415,0.06009574,-0.01861164,-0.09336411,-0.062957734,0.019751616,0.026403124,-0.029034635,-0.039862268,-0.027057951,-0.012524266,-0.062410858,0.0578181,-0.02322442,0.03871015,0.038153343,-0.022812033,-0.012960979,-0.011144426,-0.03175022,-0.07774477,-0.003308684,-4.5054314e-33,0.024815023,-0.06015026,0.041031282,-0.07121151,-0.03274222,0.086847804,-0.009960419,-0.068582155,-0.06077885,-0.030424027,0.08177529,-0.02663578,0.068314165,-0.022308137,0.06651009,0.036161736,-0.045962144,0.05838551,0.041513227,-0.0272148,-0.019889183,-0.012987318,0.019921055,-0.018026559,0.06159273,-0.027936457,-0.009629748,0.023932282,0.08844026,0.05892755,-0.05182132,0.029477298,-0.076863356,-0.089568056,-0.011302238,0.031117717,-0.09475376,-0.022212243,0.04986634,-0.0046985857,0.004429444,-0.007662699,-0.0516061,0.0707125,0.09147795,0.0395877,-0.081333615,0.047389325,0.055385645,-0.0025441782,-0.004059303,0.016480375,-0.04722595,0.0024472394,0.05657911,0.010319758,0.043555703,0.060494322,-0.03560198,-0.0002693012,-0.08100331,-0.07426981,0.014755691,0.034408882,0.09073916,0.07992592,0.06876342,0.051114943,0.0036198092,-0.096360475,0.031827528,-0.04070428,0.029298022,0.02061295,0.07803009,-0.011068779,-0.03882244,0.1088735,-0.04581578,0.039147235,0.018395083,-0.03741875,0.004075709,-0.07545005,0.03573246,-0.07384446,-0.04887841,0.01389606,0.0148903895,0.006141381,-0.05023326,0.042669088,-0.018413376,-0.006468629,-0.06315141,-3.1206802e-08,0.03747355,-0.0072177635,0.028158542,-0.027553188,0.055639736,-0.022842027,-0.027803095,-0.024519678,-0.058304846,0.0038745373,0.04556712,0.11386124,0.041957352,0.00064372754,0.0407918,-0.026884377,0.0015011798,0.014667385,-0.009863258,-0.048872437,-0.053911828,-0.036187064,-0.09044517,0.047589403,0.0091721555,-0.0235831,-0.021072008,-0.14339685,0.058659155,-0.11123353,0.037003916,0.05368698,0.011898138,-0.054616887,-0.09570634,0.034613956,-0.046010513,0.011113534,-0.027055858,0.070267916,-0.08484336,-0.04143102,-0.072141215,0.005245418,0.023227962,0.025185632,0.01782072,0.010802419,-0.11023911,-0.023416981,-0.0023745424,0.021909915,0.011456285,-0.04125088,-0.07897266,0.07446197,0.053386766,-0.05745127,0.033063736,-0.06215674,-0.05765478,-0.023447584,0.05623437,0.012484919 +1.8.99.5,"Contain siroheme. The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. In sulfur reducers it catalyses the reduction of sulfite to sulfide (reaction 1 in the right to left direction), while in sulfur oxidizers it catalyses the opposite reaction (reaction 2 in the left to right direction) [1]. The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. During the process an intramolecular disulfide bond is formed between two L-cysteine residues of DsrC. This disulfide can be reduced by a number of proteins including DsrK and TcmB [5]. This enzyme is different from EC 1.8.1.2, assimilatory sulfite reductase (NADPH), and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin), which are involved in sulfate assimilation. ",384,1.0,-0.06678002,-0.029121967,-0.03918696,-0.00011997277,0.0376793,0.009736556,-0.052173942,0.08425389,0.075504795,-0.015423872,-0.031037565,0.031449575,-0.05320475,0.026990296,-0.03599086,0.062339455,-0.017231712,0.09908797,-0.05189357,-0.0776888,0.06964231,-0.022043718,-0.06281743,-0.013808871,0.038263045,0.040058155,0.0098666735,0.001585891,-0.097013,-0.049099937,-0.010722472,-0.08534873,0.02962751,-0.0082524875,-0.004979071,0.123305626,-0.032318868,-0.016152043,0.00092178374,-0.088183366,-0.012449016,0.07002901,-0.0378108,-0.03289375,-0.028283158,-0.016915314,-0.054308143,0.027323129,0.010682071,-0.09770853,-0.062232923,0.039421517,-0.045873906,0.113119364,0.012936868,0.033202283,-0.06680935,-0.01660694,0.00781496,-0.09637639,-0.060951646,-0.018814007,-0.008718381,-0.047707338,0.062294867,-0.041016884,0.06695648,-0.03162942,0.024805365,-0.00886052,-0.09649333,-0.0073126894,0.008829714,0.063087724,-0.016413327,0.07973221,0.002336501,-0.021831246,0.06553712,-0.019729715,0.09236342,0.061086558,0.025571536,0.10468669,0.025783608,-0.03430895,-0.006476124,-0.03527112,-0.01200681,-0.028638272,0.035658978,0.020524971,-0.0096698655,-0.039765697,-0.048246376,-0.016882585,0.002612196,0.117481016,0.009161927,-0.028172117,0.012822316,0.05236757,-0.061962534,-0.10122141,-0.03430016,-0.018303696,0.02455163,0.13871817,0.026771387,0.046714958,0.011543048,0.03105966,0.037143715,0.024979409,-0.049025234,0.101160064,0.044956125,-0.011746719,-0.09019826,0.00510576,-0.014632306,0.027919235,0.027046973,0.036222227,0.0077573387,-0.02656419,-0.16125236,4.367501e-33,0.09171073,0.05898641,0.03563064,-0.030823627,-0.003804413,-0.04825313,-0.052034732,0.047666844,-0.0031884462,0.02951899,-0.05556396,-0.047735512,0.033210125,-0.04063491,-0.035366002,-0.042097766,0.018901233,0.0075428216,0.04294007,-0.015809266,0.011053009,0.054364942,0.010119373,-0.01571544,0.05905771,-0.015026448,-0.0072039175,-0.00796571,-0.027885193,0.016874138,-0.03347493,-0.115788735,-0.053033274,0.06758563,0.107592635,-0.048372965,-0.05622359,-0.022055915,0.01869487,-0.0035642479,-0.039132774,0.021779831,-0.034889504,-0.054760396,0.042266354,-0.08794023,0.004407253,0.03793165,0.014177955,0.064893655,0.048927195,-0.056642663,0.12792183,-0.0070827105,0.0044185943,-0.03322716,0.0027527418,-0.035902295,0.035856403,0.0761519,-0.003531791,0.04068189,-0.09148169,-0.013278296,0.02329183,-0.00990442,-0.062637426,-0.026187642,-0.024212614,0.10330091,-0.055158556,0.014424649,0.04863531,0.015363278,0.03081469,-0.011413695,-0.013408373,0.019996453,0.041845724,0.014226146,-0.059503637,0.004368674,-0.05160291,0.006996404,-0.062699124,-0.056102872,0.019897697,-0.0128962835,-0.012001654,0.00079523714,0.0050805816,-0.12785372,-0.09801524,0.021614755,-0.005873391,-5.5333076e-33,0.06290315,-0.0328266,0.023429163,-0.074732594,-0.06437867,0.05675768,0.054455303,-0.00017675367,0.0892737,-0.04872433,0.06649909,-0.015274667,0.026678286,-0.0024904362,-0.016324172,0.040514287,-0.028921036,0.050128374,-0.042279284,-0.006855148,-0.03048522,0.15205353,0.0704072,0.029385785,0.061964337,-0.013136325,0.07167441,0.115155496,0.0638737,0.06844427,0.0067457356,0.025255894,-0.05690783,-0.056172412,-0.034622576,0.063093156,-0.093821675,0.0019372024,0.03645584,0.044825844,0.029108744,-0.00474151,-0.014596569,0.061763093,0.040938348,0.008576613,-0.073135525,0.0476252,0.064149745,-0.06457429,0.077557996,-0.046004113,0.0022989789,0.04096208,0.021451125,0.012064113,-0.0050871405,0.015284106,-0.050550506,-0.0076070307,-0.041453242,-0.11041271,0.020811846,-0.016482873,-0.011824832,0.046978697,-0.0137186255,-0.0031273782,0.06515386,-0.007987211,0.016725566,-0.009594135,0.016590247,0.012055955,0.022851242,-0.0547803,-0.0815032,0.041345485,0.02093773,0.057893045,-0.025031237,0.057013046,-0.0142012825,-0.11893719,0.049297813,-0.048750233,-0.024486601,0.09969246,-0.045769867,0.027714022,-0.023796834,0.007937709,0.0053893947,0.10415955,-0.0064015766,-4.816385e-08,0.06055698,-0.011691551,0.08108448,0.03262278,-0.01721715,0.04131756,0.033189774,-0.018327871,-0.015390488,0.033263285,0.0031100714,0.12097454,-0.036052093,-0.064799905,0.041795306,0.0016426519,-0.057130687,0.0035754708,-0.013027217,-0.07211396,0.020969989,-0.07754204,-0.10894808,0.08219006,0.08783503,-0.07177141,0.059496835,-0.10820291,-0.044409025,-0.022716578,0.060006477,0.03434729,-0.0057672793,-0.04802517,-0.0410388,-0.0047820425,-0.04417992,-0.014060436,0.043376528,0.009545815,-0.029114904,0.03060391,-0.10708677,0.06294511,0.018999446,0.020854177,-0.016172636,0.06123926,-0.042038273,0.015492323,0.034873214,-0.021268358,-0.031799234,-0.093038015,-0.0925874,0.035667494,0.033853225,-0.04917387,0.005126314,-0.028511599,0.011395464,-0.030856915,0.08952801,-0.05308537 +1.14.12.23,"This enzyme is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms of a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It can typically act on many different nitroaromatic compounds, including chlorinated species. Enzymes found in different strains may have different substrate preferences. Requires Fe2+.",384,0.99999994,-0.061125766,-0.00095038913,-0.10257068,0.023892926,0.10519493,0.0021697325,-0.039870273,0.0118044885,0.058776222,-0.12594645,-0.08523841,-0.059989605,-0.030361312,0.00079004915,-0.06473391,-0.02382968,-0.05049199,0.019397276,-0.019874057,0.015400878,0.03849559,0.034975644,0.016360326,-0.049030557,-0.028166713,-0.005254135,0.12183139,-0.040854946,-0.04581577,-0.11796551,0.04928839,-0.0037735803,0.0058462303,-0.030079786,-0.013680534,0.092941225,-0.017080631,-0.024704909,-0.017500667,0.058470502,-0.011497648,-0.003980648,-0.044664007,-0.025725843,-0.029483613,-0.04581072,-0.021217715,-0.0006703494,0.043450654,0.013643339,-0.09327205,-0.052862722,-0.009936779,0.09979902,0.07067831,-0.056525502,-0.00847607,-0.019040998,-0.049020886,-0.012142892,0.048993587,-0.018454151,0.018653972,-0.012261632,-0.015023805,-0.020225458,0.02036934,-0.032814533,0.013467057,-0.108343326,-0.046682462,0.020156203,-0.0465823,0.057315074,-0.015816916,0.042456094,0.0915364,0.040271055,0.05026385,-0.03107717,0.029836074,0.066772,0.11617515,0.11758378,0.09238573,0.026823267,-0.063203864,-0.026817894,-0.007881842,0.04788717,-0.0019567208,0.06984826,0.0075684907,-0.022976054,-0.030744556,0.005659737,-0.033775855,0.03390565,-0.02415886,0.0039331857,-0.06540527,0.091996215,-0.012257806,-0.053675976,-0.067111775,0.0022868235,-0.050424516,0.0660699,0.0537251,-0.012784418,0.029038351,0.012404404,0.0595045,-0.02602463,-0.01824448,0.03315607,0.034702808,-0.0461106,-0.06514502,0.04243821,0.03194868,0.0046897484,0.0028382654,0.0046458216,-0.07481773,0.05615863,-0.11615105,3.584769e-33,0.029773481,0.049232285,-0.053860616,0.015867922,-0.0072477716,-0.029131182,-0.10264848,-0.0027068187,-0.043870773,-0.04643414,-0.013810818,-0.046639994,-0.00792382,-0.07107874,0.04445506,-0.06242721,0.0049232934,0.009493211,0.04068898,-0.031254817,0.011837212,0.066444695,-0.0177523,0.007827465,0.012025529,0.061271593,0.0024337268,-0.007356321,0.002613928,-0.019566001,0.08823001,-0.073122084,-0.076223165,-0.009543837,0.018754732,-0.034655523,-0.03636093,0.024691135,-0.046464745,0.045535054,-0.060760047,0.054434907,-0.033883248,-0.099270985,0.08277929,-0.14059165,-0.078533396,0.15831874,0.0883593,0.11430448,0.011301023,0.0069728247,0.091488354,-0.0013489922,-0.08804794,0.0112351775,-0.01801422,-0.022826832,0.09466272,0.06195953,0.018725926,0.05765995,0.010847659,0.03202702,0.023461258,-0.0030273253,-0.09730182,-0.020191487,0.03461001,0.12553176,-0.013085967,0.018175133,0.08560011,0.011548952,0.025960106,-0.09626885,-0.08866432,-0.035262056,0.11198667,0.014542887,0.04593497,-0.0007868567,-0.008263264,-0.035605792,-0.06506236,-0.017724587,-0.05594774,-0.010842809,-0.07540948,0.04090889,0.039591316,-0.03916852,-0.107665695,-0.07261836,0.024241976,-3.5237706e-33,0.11353759,-0.060377017,-0.030925322,-0.078820236,0.014517515,0.086469986,0.018139414,-0.0314774,-0.048424006,0.020272754,0.057460893,-0.020232905,0.017571967,-0.019241434,0.035354577,0.025007645,-0.033251856,0.043581247,0.01966058,-0.016550964,0.03274349,0.06719765,-0.023239639,0.06520824,0.0073562665,-0.022232303,-0.050771955,0.067448854,0.10466812,0.032773852,0.00022427789,0.007632725,-0.024185475,-0.031117454,-0.00082998944,0.048572708,-0.03723554,0.030232329,0.0021341515,0.0038094218,-0.024725566,-0.024129294,-0.017701512,0.08172119,0.04101273,0.0840331,-0.09832947,-0.006686298,0.04184308,-0.027985454,-0.0018731578,0.010683723,-0.02792034,0.046124086,-0.036806505,0.007697182,0.018132824,0.008417691,-0.0339744,0.0053618234,-0.0030114914,-0.042871986,0.046372797,0.011923244,0.028040243,-0.008978448,-0.015857562,0.06256582,0.0825393,-0.00083397346,0.063131645,-0.021905554,0.10612339,-0.022239381,-0.039435484,-0.035017774,0.014681678,0.040500928,-0.0003619288,0.0034217676,0.00053434906,0.015949521,0.016802935,-0.058921866,0.002288899,-0.09092892,0.03985125,0.010476528,0.02438209,0.00062052935,0.001250937,0.017741155,-0.046039116,0.013279072,0.02728328,-4.3307146e-08,0.0030568251,-0.14116897,0.047405157,0.018405523,-0.0060785823,-0.021413127,0.027448311,-0.032426,-0.07754002,0.017364407,0.015299143,0.116846055,0.0022986983,-0.041181516,0.08730632,0.02993586,0.026914818,0.060822878,-0.017162656,0.019796219,-0.030080574,0.02477977,-0.095413856,0.03956547,0.0078497315,-0.074453376,-0.04604179,-0.054413617,0.041217227,-0.0011464502,-0.01685733,0.057425573,0.0354967,-0.05271481,-0.094691955,0.0036922742,-0.05431222,0.006158065,-0.022662522,-0.020444978,-0.023501055,0.03590259,-0.04005321,0.0076015387,-0.016839555,-0.0022469093,-0.014920421,-0.03096785,-0.013353576,-0.01496419,0.052875537,-0.02280056,0.023044327,-0.005571631,-0.1008902,0.13552795,0.004230597,-0.071410686,0.058860168,-0.05067164,0.03122281,0.021647368,0.16816936,0.0010714734 +1.14.13.204,"The enzymes from solanaceous plants are involved in the biosynthesis of stigmatic estolide, a lipid-based polyester that forms a major component of the exudate.",384,1.0,-0.023943966,-0.08224988,-0.07197131,0.009766513,0.056526646,0.06424112,-0.00059006526,0.04717196,0.036099635,-0.01859016,0.061153505,-0.086720996,-0.13286014,-0.068114266,0.03257911,0.08375986,-0.09668749,0.02754269,-0.003175171,-0.016554154,0.103068106,0.069395445,-0.03268181,-0.0015665705,0.020694863,-0.05231816,-0.010300098,-0.07261919,0.0010323564,-0.066457495,-1.3985183e-06,0.041532446,0.034587882,-0.08705569,0.031172482,0.076288596,0.0096382825,-0.04360338,0.06478708,-0.016571745,0.025701063,-0.047439262,-0.065092124,-0.028452458,-0.030112734,-0.045848355,0.03429696,0.10168708,0.017281096,-0.09312413,-0.030265262,-0.075686276,-0.079281054,-0.060186025,-0.06788761,-0.0062784334,0.08061204,-0.008285864,-0.03905769,0.059072837,0.043206185,0.0038065906,0.05737477,-0.011012725,-0.02522495,-0.03457382,0.020785658,-0.025332583,0.056624122,-0.09364567,-0.020439077,-0.070078306,-0.106863014,0.021157188,-0.03910174,0.07944922,-0.05222718,0.0033315457,-0.0032960505,0.008757811,0.029363345,0.0010019578,0.037562165,0.033726543,0.06403872,-0.014192442,-0.011817743,0.055621058,0.022387812,0.053165272,0.01916884,-0.04592217,-0.05849975,0.05306013,-0.008873667,0.053733777,0.044906307,-0.049865644,0.039212186,0.0035290814,-0.0302365,-0.047220606,-0.11399355,-0.038345356,-0.041609667,-0.041042466,0.046821736,-0.03325243,-0.069654405,-0.010318643,-0.068684645,-0.038812153,-0.009239239,-0.0030035598,-0.081055075,0.06803193,0.030905193,-0.03028296,-0.028268375,-0.06911272,-0.032862626,0.06273962,0.06747931,0.09584723,0.017983072,0.016435301,-0.06088667,1.0905439e-34,0.060108032,0.022024512,-0.0036724908,-0.023011247,-0.010907727,-0.009331391,-0.03103314,-0.04383191,-0.002178278,-0.04752817,-0.086798124,-0.118937224,-0.025040226,0.047661148,0.033585943,-0.020361489,0.0039021864,0.048071552,0.0679638,-0.018180162,-0.01782849,0.01758311,-0.042724613,0.02376706,-0.022535892,0.008416005,-0.05739219,-0.025812153,0.05094741,-0.02820793,-0.009402208,-0.11264943,0.0017766282,0.07249003,0.07592582,0.04899293,-0.043683458,-0.05223063,0.00039066354,0.036590245,0.020657856,0.084087275,0.08669312,-0.038093697,-0.030631544,0.056283116,-0.08539984,0.08020985,0.059375398,-0.021064145,-0.029159019,0.106095,0.14851765,0.079445094,0.0317073,-0.019132104,-0.020209586,0.035690177,-0.016315544,-0.02909332,-0.015739605,0.031050114,-0.004642346,0.0008417035,0.008026935,0.07398507,-0.081756495,0.06621198,0.03640239,0.035259232,-0.013264726,-0.021675635,0.0618658,0.06754081,0.03617856,0.01415255,0.0022082962,0.057167172,-0.039127234,-0.014133768,0.013761665,0.006266953,-0.083719075,-0.06336727,-0.042946927,0.061920624,-0.04042205,-0.00022390063,0.050938763,0.043199837,0.033041414,0.0021369567,-0.085714564,0.064591676,-0.027915964,-1.1176161e-33,0.035462465,-0.010305759,0.02307606,-0.06877744,-0.008473602,0.012893505,-0.04815503,-0.014257131,0.014923247,0.0033617546,-0.01887866,0.031249892,0.06286119,-0.009735017,-0.07416852,0.029509993,0.047659792,0.086628556,0.007930989,-0.068113856,-0.10862114,0.05529356,-0.014957154,-0.047623165,0.046856757,0.017237697,-0.023439415,0.004999267,-0.040652227,-0.037640307,-0.00017903835,-0.023767173,-0.056031536,-0.04206472,-0.026594594,0.008785295,-0.027572816,-0.0044766557,0.027245743,0.058705274,-0.05486785,0.012631004,0.0659617,-0.0024865745,0.02128342,0.007277112,-0.060990416,-0.0041842107,-0.036852546,-0.026878113,0.009301906,0.018370703,0.06081649,0.044743024,0.055797603,-0.044517852,0.01931142,0.031623848,-0.039219152,-0.02229243,0.005301416,-0.043230526,0.00059221906,-0.051736042,0.04736896,0.0119504705,-0.023374252,0.0066999537,-0.014821339,0.0332,0.11488005,0.040429465,-0.040182233,0.13383049,0.010795566,-0.0406042,-0.036502086,-0.10329174,-0.062477883,-0.048474666,0.024252295,-0.026118498,0.017214406,-0.079257704,0.022035979,-0.00773975,0.03303047,0.044974957,0.011852035,0.04435357,-0.062405426,-0.040108956,-0.025136033,0.07694743,0.121853046,-3.0133062e-08,0.0050126994,-0.026169395,0.014138094,-0.061273027,-0.036654074,-0.014731799,0.034877293,0.021694604,0.02117981,-0.0749195,-0.090946466,0.064908005,0.045333482,0.033269312,0.06137456,-0.022559658,0.0501891,0.045400992,-0.024011375,-0.09212884,-0.028777078,0.004245991,-0.11725027,-0.018265737,-0.008101235,-0.046964195,0.076508865,0.034806214,0.052456085,0.07621067,0.060497228,0.022411233,0.04746062,-0.05082861,-0.049783245,0.08063908,0.00079218094,-0.08181084,-0.0016907429,0.05233749,-0.01260085,-0.027891856,-0.034439784,-0.0049639056,0.023531437,0.028746137,-0.042374484,0.08175393,0.018625071,0.052854206,0.065536715,0.0014892846,0.02850661,0.0051779784,-0.03450057,-0.0038186293,0.0029968466,0.07114298,0.05018603,-0.010632307,-0.024837751,0.005694278,0.2568299,-0.03407495 +1.14.13.205,"The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1). The plant enzyme CYP86A1 also acts on laurate (12:0). The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position. The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).",384,0.99999994,-0.056016266,-0.03480802,-0.0050795786,-0.05961993,0.059595224,0.083067134,-0.051775437,-0.03331995,0.0062331795,0.008989866,0.07801372,0.016693484,-0.07062981,0.07200006,-0.04052611,0.05247663,-0.023646869,0.012237453,0.025520533,0.039022356,0.093518004,-0.016802495,-0.030949026,0.027253123,0.046302833,-0.03798409,0.012305142,-0.023788111,-0.034048606,-0.05730006,-0.009972206,0.061955806,0.0149589395,-0.038252033,0.034971453,0.033085063,0.014701643,-0.0861227,0.038645275,-0.025402332,0.072275534,-0.041236535,-0.055882305,-0.022623766,-0.03567392,0.013827629,0.0377117,0.016167302,0.038512833,-0.047219373,-0.07087151,-0.06743699,-0.013609913,-0.02443077,-0.039392695,0.028589496,-0.031046472,0.03959031,-0.0027935684,0.033728074,0.018416299,-0.029974451,-0.013472005,0.03653103,8.909161e-05,-0.06793363,0.0030668678,0.011786591,-0.015652299,-0.048908792,-0.047882363,-0.07127423,-0.007622218,0.04223429,0.018883718,0.065228894,0.014423312,-0.085015215,-0.04900823,-0.026801677,0.020644104,0.0058720903,0.008970146,0.034850676,0.082862064,-0.049679097,0.019174233,0.08994269,0.007103619,0.05208414,0.09769882,0.060829528,-0.059733253,0.022824178,0.0073931203,0.112192884,0.02908108,-0.04699324,0.0258424,-0.031677794,0.022470033,0.030286303,0.0026547883,-0.10216274,0.015170397,0.05514097,-0.05585612,-0.006495849,-0.020374676,0.03419741,-0.038975842,-0.0063370937,-0.00870804,0.004557577,-0.024324859,0.012366764,0.021806955,-0.033925913,-0.08734549,-0.035030644,-0.03239073,-0.056462582,0.030066852,0.09632942,-0.0062719663,0.049661554,-0.10246064,2.1711908e-33,0.09476375,0.010832206,-0.0105266,0.0039253724,0.004903882,-0.069048606,-0.017523268,0.0038570839,-0.103142574,-0.046177372,-0.09128487,-0.08417176,0.012214934,-0.017369049,-0.047327902,-0.010051499,0.024699561,0.02381866,0.064441524,-0.004536222,0.006592369,0.061191224,-0.09195917,-0.04186919,0.003589009,0.05450395,-0.05841945,-0.041122302,0.04317494,-0.0300918,-0.015820704,-0.08838995,-0.10662553,0.07920705,0.08987166,0.008980746,-0.021524388,-0.119540066,-0.008582828,0.042379387,-0.041245587,0.008212075,0.08288551,-0.014946107,0.03689787,-0.009383184,-0.09799743,0.042184085,0.08045362,0.06505495,0.08497531,-0.027255774,0.07782046,0.056539204,-0.10328378,0.046998072,-0.044444136,0.004172423,0.0034972092,-0.042348474,0.0066656433,0.030938637,-0.05598725,0.02136188,0.034557667,0.028676191,-0.09405419,-0.023179447,-0.038960554,0.081976995,-0.020247504,-0.076779194,0.07419922,0.06525356,0.072488114,0.0001371195,0.0021974174,0.018392248,-0.019688746,0.075595364,0.030877732,-0.025404692,-0.013481279,-0.031360902,-0.09989968,-0.023887714,0.009999405,-0.00042431042,0.028559078,-0.029405873,0.09453359,-0.097713545,0.025282547,0.013637269,-0.037117276,-4.1146134e-33,0.09734277,-0.026778743,0.10561395,-0.07268959,-0.0890414,0.046681385,0.00041646694,-0.08259904,-0.019065285,-0.034414496,0.029016977,-0.06630218,0.03372514,-0.03095093,-0.07859196,0.054647762,0.035344355,0.08679324,-0.07323786,-0.020716395,-0.08329659,0.075977616,0.022390503,0.08738577,0.059768956,-0.060556974,0.101972535,0.059782468,0.028824836,0.01024227,-0.020460732,0.023929602,-0.061849035,-0.02455364,0.0014465473,0.025902636,-0.1280268,-0.009962534,0.023756532,0.046862446,-0.02975759,0.016540889,-0.0117644165,0.06928475,0.060039192,0.042840715,-0.04397801,0.022245267,-0.027963396,-0.0067595127,0.0040904414,0.07252858,0.047559362,0.01343225,0.0919857,0.016728438,0.049292352,-0.006708025,0.004784551,-0.05737267,0.041039012,-0.038641542,-0.01904002,0.036521222,0.023015093,0.07969087,-0.07276416,0.010252919,-0.06447664,0.014988051,0.021315271,-0.0037861927,0.03839774,0.08803097,-0.032315224,0.018229818,-0.02784374,-0.06780477,-0.056349494,-0.040205866,0.010062467,0.018531121,-0.01208969,-0.059943285,-0.035281498,-0.03964621,0.048028328,0.09057692,0.03145369,-0.04546759,0.0031015042,0.018658761,-0.010047985,0.0482135,0.057114985,-4.8752877e-08,0.04285967,-0.023073537,0.059643894,-0.11474997,-0.07384634,0.017623276,0.050708264,-0.056575615,0.04965273,-0.09431468,-0.08286409,0.069799155,0.010018394,-0.008343556,0.05418288,0.0064299465,-0.02851852,-0.001528899,-0.031721115,0.030854661,-0.03821496,0.020712726,-0.16149668,0.054280635,0.017773943,-0.0035727094,0.030552525,0.14952081,0.048403464,-0.029185504,0.03126091,0.038192667,0.00026830644,-0.028645383,-0.06464274,0.081026174,0.013508194,-0.021520434,-0.009527006,0.07387445,0.00075136713,-0.09850304,-0.033486247,-0.037244644,-0.040964805,-0.011636721,-0.0032165693,0.013327712,0.055918045,0.030247862,0.08680271,0.049295165,-0.066316605,-0.07225815,-0.049019966,0.004995096,0.019418927,-0.030999763,0.0019512891,-0.05783629,-0.06452219,-0.041325532,0.10763298,-0.01148651 +1.14.18.4,"The enzyme, characterized from the plant Ricinus communis (castor bean), is involved in production of the 12-hydroxylated fatty acid ricinoleate. The enzyme, which shares sequence similarity with fatty-acyl desaturases, requires a cytochrome b5 as the electron donor.",384,1.0,-0.09238296,-0.05885973,-0.11585376,0.012525237,-0.033166833,0.067429855,-0.037460305,0.022253169,0.0047937864,0.0023365065,0.07181794,-0.086970575,-0.04894867,-0.048033677,-0.024885241,-0.042379405,0.008688811,0.0046761394,-0.072240315,-0.13739422,0.08776458,0.026428252,0.0025166227,0.050692298,0.018243853,0.004380278,0.015916588,-0.06287798,-0.008724435,-0.07254629,-0.01741341,-0.027921423,0.075234406,-0.07520044,-0.0017966401,0.04975201,-0.0103173,-0.07727333,0.06715712,-0.03306932,0.037287913,-0.0418005,0.03961258,0.035322145,0.010306236,-0.09168655,-0.000817182,0.065002546,0.057821076,-0.117709585,-0.063654505,0.014356702,-0.03278852,0.013262349,-0.020400373,-0.0066899536,-0.009182702,-0.03087995,-0.035815,0.01307607,0.0029548118,0.0031767106,0.016108684,0.023301214,-0.03708353,-0.0656658,-0.058062356,-0.031838696,0.072926335,-0.0013409302,0.0015467769,-0.12639292,-0.029722404,-0.024296785,-0.031322576,0.08694171,0.011439134,0.025445607,0.013106897,-0.026818536,0.037441384,-0.032765914,0.032088436,0.05144364,0.0084839435,0.03475583,0.057262845,0.009521264,-0.027130904,0.022259895,0.07797749,-0.016950028,-0.031195968,0.0009999226,-0.11224586,0.015071332,0.01881636,0.009803717,0.02980877,-0.0121204415,-0.020770099,0.0223208,0.005881362,-0.06082471,-0.111443676,-0.0037655584,-0.09278643,0.04513637,0.07975991,-0.041704036,0.014176304,0.012122594,-0.05157631,0.11537171,0.013183412,0.028178522,0.025295911,-0.085467935,-0.009642189,-0.0083649475,0.01663415,-0.0494084,-0.024774529,0.06399956,-0.020393072,-0.04491567,-0.08234317,1.2408568e-33,0.0789828,-0.028962882,-0.06898355,-0.016224066,-0.008597334,-0.03817469,-0.09480812,0.041854657,-0.07230392,-0.026551304,-0.066105865,-0.013402788,0.02564755,0.059175577,-0.030642645,0.0063223233,-0.042720307,0.045225047,0.09460694,-0.03637947,-0.016350381,0.12174406,-0.05040889,-0.032005277,0.0035888322,0.09720159,0.0014838899,-0.08762188,0.03575106,0.025355881,0.0059224763,-0.07781173,-0.031472318,0.07171516,0.042104743,-0.0030008361,0.035972834,-0.01937289,-0.046794154,0.07456091,0.013695525,-0.0026891376,0.011025707,0.0019291708,0.07449027,-0.005493404,-0.027875835,0.09304435,0.0678246,0.093665406,0.02595654,0.011012268,0.18957385,0.053898986,0.02092618,0.07712264,0.0020529989,0.016690407,0.011798459,0.047226112,-0.013448242,0.086919114,-0.066766135,0.030489504,0.015661014,0.015533343,-0.032037456,-0.079254024,0.00016218188,0.14471489,-0.016787339,-0.00015395039,0.005360232,0.038654383,0.047583476,-0.0073578246,-0.0016614624,0.032717224,-0.060777314,0.08169292,0.001120339,0.04036223,0.0141050145,-0.006494265,-0.10741363,0.06820991,-0.047281664,-0.017535208,0.015617423,0.038447928,0.036356878,-0.015093179,-0.08653909,0.07055821,0.031797815,-2.1267273e-33,0.105103254,-0.12961613,0.04908866,-0.017994562,-0.086608864,0.0071906354,0.0042671263,-0.019507507,0.10208878,0.01681767,0.0732611,-0.012872232,0.0242203,-0.023430152,-0.032462448,-6.7429e-05,0.0010832621,0.09284949,-0.06809233,-0.020360678,-0.03663746,0.12256054,0.0066715996,0.0354224,0.025150117,-0.01114156,0.036676526,0.10652287,-0.033546455,-0.015097499,-0.019654352,-0.07714456,-0.025514895,-0.08966723,-0.054726213,0.05510045,-0.061902437,0.043261267,0.0011980516,0.08319253,-0.0057112314,0.07287031,0.038241275,0.023780938,0.049578074,-0.035031695,-0.0689978,0.07622241,0.030866213,0.0015616559,0.05563507,-0.0103388,0.027054083,0.025830284,0.011194541,0.031289786,0.020006321,0.054834623,-0.057946134,0.012847603,-0.013334645,-0.09311831,0.06403464,-0.037595242,0.049403083,0.06650446,0.0049482915,-0.029671406,0.050000794,0.021614226,0.07696083,-0.022364229,0.0051338775,0.10367171,0.000643446,-0.021208249,-0.07331492,-0.04147828,-0.029942818,-0.040562246,0.0028124307,0.006376145,0.03877412,-0.07734588,0.027387109,0.018763376,-0.019612197,0.07398399,0.11223925,0.057012685,0.01090406,-0.017049475,-0.031080117,0.0047049727,0.057692356,-3.668707e-08,0.014531793,-0.031748414,-0.005662675,0.00017481437,-0.021278383,0.035861168,0.025097538,-0.072382554,0.034298718,-0.045442663,-0.0705691,0.08803093,-0.064603396,0.03981897,-0.022858676,-0.0041389926,0.0027364064,0.0032192324,-0.006212607,-0.035190158,-0.048074182,-0.05381743,-0.04075144,0.0036093493,-0.01505672,-0.05601028,0.030987553,0.04917111,0.04722102,0.0046854457,0.0018621576,0.006464622,-0.022909947,-0.026440466,-0.023316685,0.030930966,-0.044722084,-0.03722759,-0.052622195,0.056712266,-0.034580875,-0.044051316,-0.030270064,0.00224793,-0.04379529,-0.016570894,-0.05173476,0.025515065,0.002722571,-0.0070025916,0.015854806,-0.022219064,-0.006667762,-0.0778876,-0.11335717,-0.05632194,0.048862953,-0.0472991,-0.00091641786,-0.011649821,0.01535128,0.0034597055,0.16723348,-0.052622084 +1.14.18.5,"The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase [4].",384,1.0,-0.06432606,0.009008634,-0.11438801,-0.021518862,0.016279338,0.04252358,-0.05474218,0.023567565,-0.026443006,-0.013687337,0.004212964,-0.08219138,-0.1057917,0.051498022,0.00242789,0.0641947,-0.12833099,-0.022806538,-0.03617218,-0.08992175,0.060542606,-0.047064807,-0.045432344,0.05653285,-0.012491332,-0.020215854,0.041275322,-0.04530473,-0.05457371,-0.069235876,-0.03273095,-0.02570517,0.02061578,-0.080857225,0.025746437,0.10955945,-0.02545852,-0.021101145,0.01541189,-0.036870092,0.05096176,0.028160779,-0.08250036,-0.0021106168,0.00407918,-0.00965374,-0.0030965533,0.037454274,-0.027872046,-0.019152483,-0.02766564,-0.048792943,-0.08522313,-0.014981881,0.012929133,0.001006266,-0.046599835,-0.035295594,-0.018403316,0.016624756,0.036107026,-0.023136431,-0.03923089,0.01029525,-0.035032984,-0.071261674,0.036344256,-0.10507546,-0.0129211405,-0.012358946,-0.021387063,-0.14546433,-0.06414401,0.011779932,-0.028967194,0.07471591,0.0003684528,-0.0024506103,-0.011124233,-0.038114436,0.062812835,-0.031591717,-0.0052307346,0.08770453,0.05883133,-0.026394254,-0.0212717,-0.012529687,-0.0022260174,0.0349173,0.04640136,-0.041104693,0.0028643932,0.011692054,-0.05409165,0.048857905,-0.020701421,0.024688154,0.018041736,-0.04821131,0.037907712,0.06400713,0.040485635,-0.05397195,0.014430769,-0.019725,0.03338383,0.09080755,0.021963544,-0.026012262,0.010489494,-0.040670056,0.08469455,0.0067698187,0.015988626,0.07077471,-0.009528336,-0.048766132,0.020885078,-0.00042699472,0.040666368,0.058382403,-0.018831713,0.03253714,-0.004832892,0.018009031,-0.13071151,3.367668e-33,0.03244719,0.0067319106,0.0009209702,0.0216187,-0.06180198,-0.004573286,-0.06578381,0.0015004298,-0.07542454,0.0060106586,-0.09531946,-0.021404674,0.038210426,0.012433469,-0.0074122488,0.015762556,0.00012929244,0.016491998,0.03901188,0.050470963,-0.02687583,0.016480818,-0.08171107,-0.11868506,0.070195735,0.08473371,-0.08029095,-0.011456938,0.007570995,0.007306033,0.01536129,-0.06527715,-0.1028588,0.028155971,0.066389546,-0.031636763,-0.0028600693,0.0021248737,-0.03145951,0.03903687,0.009865433,0.0011234521,-0.04691823,-0.055464048,0.075914964,-0.026972001,-0.09694941,0.0681226,0.07037854,0.028205568,0.030042104,-0.03439391,0.1270143,0.043533437,-0.016710151,0.06656017,0.030413128,0.019871192,-0.010930105,0.06497294,-0.0062495368,0.11968633,-0.064198166,0.03220942,0.093259394,-0.013934604,-0.006612419,-0.030932426,-0.09596098,0.024193749,-0.039378922,0.013948606,0.13403516,-0.0062991013,-0.016117444,-0.018021805,0.0057574534,0.023966545,0.00017854937,0.06990775,0.035386674,-0.035754815,0.006430305,-0.0630119,-0.0029961674,0.024248185,0.0046822187,-0.03514243,-0.01281371,0.06583557,0.0012298474,-0.09322361,-0.043115772,0.060779363,-0.035077926,-5.6712085e-33,0.03235125,-0.088345215,0.05421608,-0.15427586,-0.08037642,0.11769136,0.031315304,-0.04362695,0.0402924,0.06630079,0.011561266,-0.03226646,0.06366217,0.008676039,-0.013127066,0.020982806,-0.052813545,0.04381692,0.048013482,-0.037605852,-0.008634361,0.09980112,-0.024789281,0.07380935,0.06853312,0.011802251,0.02592044,0.06564629,0.012039376,-0.0389767,-0.040696748,-0.047114506,-0.030189674,-0.046147034,-0.000135785,0.0011695321,-0.05480278,0.06558338,0.07416791,0.014798769,-0.044583187,0.09203061,0.052583586,0.048905514,0.098741844,0.04798163,-0.094369106,0.08661309,-0.020520166,-0.07594317,-0.0329435,0.016859274,0.014158213,0.029238636,-0.027229263,0.013056888,0.004504641,0.05924998,0.0125080375,-0.06188856,-0.043441653,-0.091517426,0.062329974,0.020295376,0.037129283,0.06707457,-0.06535155,-0.005826378,-0.022531953,-0.038296912,0.013667946,0.0113138985,-0.06729893,0.060546674,-0.0360273,0.0083902925,-0.053769547,-0.11725807,0.05506451,-0.014215396,0.03805184,0.020637322,0.013781147,-0.027017204,-0.0028592185,-0.1065322,-0.019688727,0.059620865,0.06257996,-0.024904098,0.01160625,-0.021340718,-0.046087317,0.013679017,0.07076489,-4.0267558e-08,0.07743823,-0.0023777229,0.03071352,-0.06128129,-0.01868571,-0.0011067174,0.025326818,-0.022369877,0.06131407,-0.0268867,-0.042205498,0.057200726,0.036852125,0.03218842,0.029516181,0.077387035,0.0039625457,-0.032127623,0.05465048,-0.0043161246,0.03741797,-0.035919227,-0.077366285,0.03620783,0.02529524,-0.0811186,0.06417521,0.030804537,-0.008658148,-0.016333023,-0.00040865477,0.018069651,0.023649449,0.048983376,0.022917937,-0.037381846,-0.01858359,-0.040226378,-0.056919508,0.05986922,0.0013109024,-0.09814078,-0.052672513,-0.007391831,-0.040091168,-0.023949843,0.05299007,0.01436683,0.05644412,0.035352707,0.0023113443,-0.032201342,0.013682842,-0.08823865,-0.10503322,-0.024747254,-0.0037377698,-0.020521848,0.0046051666,-0.011454346,0.03125644,0.12587641,0.20056613,-0.03676694 +1.14.18.6,"The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase.",384,1.0,-0.049301717,-0.05159756,-0.05137207,-0.018214613,0.010609052,-0.03396867,-0.099742524,0.044044793,-0.02333883,-0.03223784,0.020820996,-0.13723332,-0.0964178,-0.009937572,0.028175175,0.006207387,-0.028063223,-0.014330931,0.022489158,-0.040928707,0.09685531,0.0059602205,-0.024945421,0.0121189505,0.021046316,-0.002572204,0.05056746,-0.035869833,-0.010320559,-0.118490346,0.11239602,-0.057268742,-0.009072563,-0.0027713566,0.0015174545,0.029283917,0.0041444777,-0.07006612,0.0410443,-0.0101912385,0.029182484,0.0015582234,-0.012185359,0.021472467,0.022050278,-0.012785993,-0.021396685,0.11157978,0.06685018,-0.038953066,-0.05266201,-0.04888151,-0.034659382,0.036407273,-0.052588403,-0.013431603,-0.0023281216,-0.009908355,-0.018830916,0.009557793,0.039791714,-0.0057850266,0.0058260467,0.029717585,-0.033362307,-0.0656552,0.0015212332,-0.0850767,0.01658405,0.00054076355,-0.09452541,-0.11511899,0.049899556,0.026493184,-0.052916367,0.04709812,-0.038374282,-0.04744557,-0.00065321865,-0.067108,0.076741986,0.004581874,0.069575734,0.098044544,0.07354642,0.035112854,-0.009017292,-0.058241967,0.0075768903,0.053463858,0.025926119,0.009666536,0.016376939,0.08230558,-0.07186942,0.06809947,0.060934056,0.08662927,0.013054536,-0.017284574,-0.0057004,0.053528305,-0.013114534,-0.08832555,-0.085101075,0.0044668987,0.014578758,0.08813212,0.011609772,-0.05450346,0.013256127,0.04833698,-0.004954841,0.07226159,0.0037083875,0.060191885,0.05417209,-0.07212968,0.024221173,-0.112983,-0.034435384,-0.02105784,0.035164464,-0.042064637,-0.07397459,0.01088221,-0.0800009,1.673338e-33,0.039170027,0.004390078,-0.01953316,0.002641131,-0.038065042,-0.00040853495,-0.125906,0.049975704,-0.07652023,-0.0065514487,-0.021424672,-0.03864128,0.017635768,0.07922522,-0.027090171,-0.07729028,0.06707377,0.060721204,0.107391015,-0.028240543,-0.02316231,0.053209964,-0.025102533,-0.070109926,0.024139272,0.08962493,-0.029126326,0.020455169,0.018065674,0.020487638,-0.081631094,-0.095593214,-0.05055693,0.09408095,0.053459864,-0.017872069,0.0145841185,-0.019848514,-0.0049520205,0.0239535,0.036091153,-0.044788122,0.025645845,-0.075445056,0.008887577,0.015490767,-0.03398753,0.040759727,0.021672105,0.045991845,0.019764785,0.0122940615,0.069391064,0.014219758,-0.020326013,0.016302843,-0.023247713,0.009525136,0.025154104,0.008858611,-0.049994156,0.11440262,-0.0921135,0.009415351,0.00466433,-0.020396305,-0.047545858,-0.052161593,-0.03765581,0.089998424,-0.027469879,0.0062103155,0.15764636,0.043002944,0.06537226,-0.024069704,-0.044583805,0.04767243,0.015743075,0.091458574,0.027612485,0.0014439672,-0.03385586,-0.020190228,0.015621354,0.05094435,0.021197747,-0.027483562,0.009494661,0.045695223,-0.0323983,-0.10413908,-0.0057815704,0.02015263,0.06268814,-3.0355219e-33,0.066188075,-0.048859943,0.030038368,-0.057477117,-0.023637474,0.02050261,0.044841327,-0.06275884,0.059798744,0.009781911,0.08817248,-0.008512461,0.041653045,-0.067199185,0.043455932,0.0143244825,-0.047988553,0.011607991,-0.051536717,-0.065845035,0.12254186,0.06549157,-0.03351402,0.098121025,0.08742365,0.0061283098,0.0711506,0.062904485,0.04896461,0.022307668,-0.0655946,0.024908213,0.010117245,-0.033269875,-0.021448854,0.028937723,-0.1277678,0.07959257,-0.013333359,0.01727926,-0.07624869,0.060005557,-0.04767259,0.04656207,0.09813674,0.066714756,-0.048201997,0.026930375,0.029490704,-0.004311619,0.051777203,0.022764208,0.04016122,0.0066721262,0.035051662,0.026721872,-0.017070768,0.061520852,0.037136357,-0.044650067,-0.049579144,-0.07882417,0.032134145,-0.043738876,0.018374784,-0.007993913,-0.079750046,-0.0013337552,0.0025767444,0.040032554,0.051389612,-0.020445893,-0.042314086,0.05085965,-0.06587254,-0.04981141,-0.047642227,-0.112952195,-0.068584114,-0.0025928712,0.019650394,0.013629796,0.06673374,-0.0627588,0.021882802,-0.036205143,-0.035945337,0.06145799,-0.033845257,0.03154919,0.006097614,0.010454995,-0.05758091,0.059043247,0.09655862,-4.006652e-08,-0.019935641,-0.020386005,0.062197253,-0.03416626,0.0026350922,0.00597105,-0.015693942,-0.010911612,0.07345205,-0.0845037,-0.049326655,0.10588876,0.04079708,0.0794796,-0.032975234,0.032417852,-0.0004950673,-0.035161898,0.023031853,-0.013845126,0.03450766,-0.050288018,-0.07261326,0.04683879,-0.017088952,-0.07213848,0.01451583,-0.010205267,0.022754513,-0.0026025486,-0.011979162,0.034360122,0.04424205,0.0047179847,0.03616706,-0.013800976,-0.07418547,-0.06713139,-0.04196268,0.05362263,0.03545618,-9.9128076e-05,-0.0023999056,0.041568283,-0.0623751,-0.014965024,-0.0049451804,0.0341742,0.0040207445,-0.0066642435,0.042639688,-0.025422167,-0.053621043,-0.065341264,-0.09270558,0.021238593,-0.06873873,-0.040803604,-0.03826139,-0.05081965,0.03654613,0.02969952,0.17729728,-0.06044756 +1.14.18.7,"The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase. ",384,1.0,-0.066981494,-0.0684737,-0.047686037,0.014338185,0.060341366,0.032879233,-0.08919732,0.042614814,-0.033401463,-0.033727113,0.06490201,-0.1281387,-0.091630384,-0.014659704,0.0015882826,0.05586435,-0.06146992,-0.018169975,0.02679763,-0.069185324,0.041162908,-0.03289578,-0.04088851,0.028146358,0.015616066,-0.012809334,0.0040722387,-0.0451412,-0.015039547,-0.050444655,0.102105685,-0.02369534,-0.0058484795,-0.02909903,-0.009601075,0.045014784,0.008557357,-0.07057576,0.030942354,-0.010960109,-0.0043658037,-0.011663076,-0.011001221,-0.040404946,0.05430805,-0.0227876,-0.024457706,0.102246135,0.0070473333,-0.069330566,-0.07334293,-0.085731894,-0.07706122,-0.010900871,-0.033967912,-0.01681463,-0.03830116,0.0119655365,-0.020133313,0.041651856,0.045454726,0.0009290077,-0.0060541285,0.04455267,-0.025997479,-0.0842299,-0.024392473,-0.09955086,0.008533971,0.037874136,-0.08071717,-0.129394,0.07415292,0.016433429,-0.04232651,0.03643802,-0.045376137,-0.036231138,0.01736114,-0.07322833,0.033852942,-0.018083822,0.0044115093,0.11039025,0.058679663,0.05237602,0.015115963,-0.009015837,-0.012494759,0.08138054,0.056513004,0.03010276,-0.019709714,0.059319578,-0.08806411,0.073880956,0.06900776,0.04919749,0.007689387,-0.021755395,-0.0060282284,0.03182867,0.013795314,-0.12818961,-0.076455444,-0.016817128,-0.016933303,0.07035085,0.050714713,-0.030106623,0.016663432,0.06197687,-0.016304541,0.005635371,0.00096190424,0.091488816,0.029679114,-0.06842296,0.0014135388,-0.056716748,-0.020898286,-0.009414417,-0.020667654,-0.034440454,-0.09438638,0.0029061274,-0.054683745,2.7821999e-33,0.05068639,0.022034505,-0.0022114085,0.020540182,-0.04363968,-0.0076056477,-0.12084096,0.04142551,-0.07020212,-0.016646286,-0.056657884,-0.053215105,0.01114249,0.05203662,-0.0068765185,-0.06684158,0.0049714604,0.038212206,0.14094396,-0.016994428,-0.027178714,0.001277358,-0.038260303,-0.03255819,0.03114368,0.079866275,0.026736615,-0.024207953,0.014906508,0.027031532,-0.035886403,-0.056628387,-0.07256341,0.05468995,0.040821113,-0.0364318,0.021865593,-0.027448291,-0.027513528,0.056653436,0.054591313,-0.016548356,0.04544731,-0.029804599,0.014593023,0.010097573,-0.042553734,0.058973126,0.07862296,0.030318065,0.01852972,-0.012150098,0.075275384,0.06188462,0.0031081364,0.031634532,-0.020957801,0.015563709,0.033647344,0.0069963085,-0.014296169,0.10916266,-0.055261098,0.014900815,-0.025087196,-0.015605129,-0.06293925,-0.054492358,-0.04128546,0.026577864,-0.016229214,-0.009276225,0.15694527,0.052118246,0.054014403,-0.026482536,-0.019822141,0.010738367,0.016444411,0.086433165,-0.02534569,-0.015813125,0.0027406944,-0.016246922,0.004485682,0.036804277,-0.014384703,0.009024088,0.019285934,0.042788375,-0.0023242198,-0.12552753,0.002737991,-0.0022884058,0.013942194,-3.1275203e-33,0.040746965,-0.059372954,0.0046373038,-0.08542756,0.0020093494,-0.021737326,0.04216339,-0.0715732,0.084058076,0.029165218,0.047908626,0.017100882,0.077371,-0.03176938,0.018345607,0.014381031,-0.042432047,0.013941189,-0.03596048,-0.037616145,0.09219574,0.034584403,-0.022877086,0.10828685,0.06179015,0.068438075,0.020726064,0.059156593,0.061443686,0.050877534,-0.062296383,-0.012373725,-0.025952084,-0.008390635,0.019419136,0.033762,-0.075358175,0.076435246,0.0014217355,0.050137997,-0.10747688,0.06362539,-0.04947406,0.07850965,0.12636404,0.05565158,-0.050495014,0.033188056,-0.009756627,-0.023871677,0.017251603,0.051562473,0.019789757,-0.0019217632,0.027513713,0.0030539436,-0.06565312,0.07136976,0.01757862,-0.054612298,-0.0392962,-0.087118,0.016644098,-0.02353907,0.019018121,0.05852864,-0.04982763,0.030126808,-0.033075593,0.004103103,0.01446616,-0.032931548,-0.02958942,0.06697578,-0.05493615,-0.056219444,-0.02828982,-0.09589495,-0.071131095,-0.004034178,0.06471643,0.019749995,0.078873195,-0.044818208,0.023927042,-0.039095476,-0.032402325,0.043293886,0.011939232,-0.013434028,-0.004118183,0.055773612,-0.051820807,0.05563279,0.129347,-3.9811408e-08,-0.031551328,-0.077659436,0.085500695,-0.04826076,0.035004243,0.019724654,-0.02813017,0.0010077921,0.10655743,-0.13370177,-0.09542878,0.108730316,0.04615573,0.07792915,-0.023141269,0.02576974,0.0027574508,-0.034329206,-0.0035713094,-0.03222057,-0.014176105,-0.03433291,-0.08328402,0.032392032,-0.017210942,-0.06915831,-0.01481311,-0.0019866915,0.004372639,0.03248617,0.012333968,0.045142855,0.04681933,0.05660381,0.030580122,0.040566638,-0.048126213,-0.034082696,-0.0608185,0.059392404,0.01636027,-0.014203155,-0.028620461,0.029792143,-0.01412874,-0.034309953,-0.025902554,0.017035611,0.04181444,0.031407297,0.069600634,-0.025958443,-0.040863354,-0.06754031,-0.07345692,-0.008664382,-0.032009438,-0.025251865,-0.0070497617,-0.0548065,-0.0007,0.054790094,0.20499854,-0.03440483 +1.14.19.11,"The enzymes from the plants Coriandrum sativum (coriander) and Hedera helix (English ivy) are involved in biosynthesis of petroselinate [(6Z)-octadec-6-enoate], which is formed by elongation of (4Z)-hexadec-4-enoate. The ivy enzyme can also act on oleoyl-[acyl-carrier protein] and palmitoleoyl-[acyl-carrier protein], generating the corresponding 4,9-diene.",384,0.99999994,-0.031239511,-0.054047253,-0.08516531,-0.05673145,0.01916871,0.07549077,-0.10330909,-0.04615945,-0.017349193,0.01516962,0.05754221,-0.040892996,-0.10871092,-0.02415248,-0.039580733,0.014707876,-0.15021223,0.036218245,-0.07512832,-0.0806441,0.04715353,0.0034743792,-0.028635874,-0.036751274,0.035199795,-0.015050189,0.024815442,-0.034581695,0.023232102,-0.054941706,0.034384355,0.038938858,-0.052680757,-0.061990682,-0.016642937,-0.0056593963,-0.027906785,-0.11721154,0.07776745,0.052960195,0.07638639,-0.0021551866,-0.06694017,-0.0060000094,-0.116819516,-0.08086237,-0.025767196,-0.02370787,0.034825396,0.005955217,-0.014027076,-0.0023445645,-0.09134416,-0.055687495,-0.0680612,0.038717367,0.03587789,0.037268132,0.011133529,0.053472657,0.10035572,-0.008403832,0.019969849,0.029781785,-0.041717462,-0.011461939,-0.05406215,0.02091312,0.009950614,-0.03453877,-0.03547673,-0.081895776,0.015153895,0.077968165,-0.05798699,0.096101575,-0.036294628,-0.04397469,-0.0009767304,0.014156588,-0.003907385,0.045881588,0.0067659263,0.04925837,0.049533334,0.041845094,0.009311726,0.04046464,0.10854422,0.03311924,0.08461751,-0.016330896,-0.0969688,-0.02878279,-0.049677443,0.11417342,0.06618101,-0.028726723,-0.044662304,-0.0648531,0.0077837077,-0.0023998143,-0.004296341,-0.0029658051,-0.018092072,-0.009124048,-0.032166805,0.06930733,-0.052790605,0.017765468,-0.02267021,-0.041650113,0.013755322,-0.035555795,-0.012129003,0.10502666,-0.042529907,-0.06895642,-0.025370175,-0.07541063,-0.013112045,0.026311383,0.043689504,0.050180178,0.0025417788,-0.0059245448,-0.14320193,1.2841862e-33,0.039398704,0.084178925,0.018039063,0.0056880894,-0.041881986,-0.102323316,-0.07280009,0.07117107,-0.050589904,-0.07122133,-0.075821124,-0.02349129,0.056376237,-0.056981437,0.017184902,-0.03713995,0.032282334,0.004036588,0.024639336,0.010429819,0.009193852,0.08143659,-0.0797065,0.04265164,-0.044319328,-0.0026523354,0.009423414,-0.044198114,0.050576326,-0.03148379,-0.013250686,-0.075240865,0.0019106071,0.049448732,0.10244153,0.029293792,-0.05637893,-0.059760794,-0.046545804,0.03953118,0.08604469,0.05537094,0.03378441,0.019709118,0.0061532254,-0.00059980457,-0.030076245,0.026547845,0.04250301,-0.01683145,0.046068233,0.08407971,0.11754904,0.043632086,-0.069067255,0.03217736,0.020427736,-0.006642369,0.06211724,-0.0015611039,-0.023070714,-0.08353347,-0.007392575,0.051341444,0.044318523,0.015450698,-0.09440049,-0.0064574447,-0.012728785,0.08327713,-0.035172734,-0.02687189,0.021080466,0.032393545,0.076514296,0.042384047,-0.022077687,0.03568457,-0.056147803,-0.021242674,0.020089522,0.04989129,0.013791867,-0.030673867,0.016661055,-0.043930244,-0.066283554,0.031077374,0.06090816,0.029636068,0.11194068,-0.014108697,-0.047523078,0.023740444,0.011695516,-3.624657e-33,0.018031921,-0.09446144,0.038664997,-0.04774627,-0.045889262,0.14974263,-0.017862877,0.027179254,-0.015213066,-0.014484682,0.06075804,0.06330535,0.07337713,-0.09063197,-0.035350922,-0.03626356,0.039345454,0.09406721,0.042648703,-0.006864068,-0.048831075,0.04458364,-0.035835367,-0.025294129,0.040708907,0.0058163796,0.04363447,-0.018810792,-0.023589458,0.0405174,0.11040591,-0.014541488,-0.019628014,0.055333897,-0.018512087,0.0030217248,0.030984161,-0.031245263,0.0006568464,0.04141835,-0.024750022,-0.050059054,0.066397876,0.048516907,0.06026748,-0.074782446,-0.04411959,0.09710984,-0.061192308,0.03909965,0.014870228,0.013440604,-0.05659717,0.0022098455,0.039843664,-0.007840507,0.09171522,-0.05423407,0.035176255,-0.019795457,-0.0205845,-0.04502394,-0.015667234,0.03927829,-0.00793863,0.017627073,0.0008567014,0.06213216,-0.049071334,-0.0023383468,0.061745897,0.034448855,-0.026601044,0.09516555,0.040987656,-0.04325903,0.019333921,-0.08141644,-0.0544297,-0.011670204,-0.07828754,-0.040717218,0.073590115,-0.064911865,-0.022038788,-0.055058908,0.03941084,0.09251262,0.00092131505,0.017704563,0.0057958807,-0.039352797,-0.04634786,0.05382579,0.069473445,-4.3959453e-08,-0.03234331,-0.032750133,0.017000845,-0.046008848,-0.049392268,-0.0015599297,0.031067032,0.0024701757,0.09511764,-0.043568578,-0.015940038,-0.03197005,-0.04196059,0.015390368,0.013637157,0.0027565218,-0.010896912,0.06158831,-0.0073063835,0.003935025,-0.04225684,-0.013186409,-0.025980432,0.015019359,-0.03310585,-0.043659266,0.029375868,0.07726258,0.03559185,-0.027392024,-0.006778572,-0.0025665136,0.013051619,-0.036023255,-0.096360266,0.049296387,0.100170165,-0.060887124,0.0141184265,0.078215696,0.0043013645,-0.06763677,-0.05976739,-0.0059457063,0.042055592,0.052735943,0.020499112,0.007934413,0.04560647,-0.013307582,-0.024898708,0.0012770073,0.03986718,-0.13462025,-0.06743054,-0.023777418,-0.044529833,0.012690093,-0.012354614,-0.043257367,-0.024589267,0.028348548,0.17626764,-0.0036664847 +1.14.19.12,"The enzyme, characterized from the green alga Chlamydomonas reinhardtii, is a front-end desaturase that introduces a cis double bond in omega9 unsaturated C18 or C20 fatty acids incorporated into lipids, at a position 4 carbon atoms from the existing omega9 bond, towards the carboxy end of the fatty acid (at the omega13 position). When acting on 20:2Delta(11,14) and 20:3Delta(11,14,17) substrates it introduces the new double bond between carbons 7 and 8. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor for the active site of the desaturase. ",384,1.0,-0.13155557,-0.023286037,-0.11935632,-0.031018788,-0.052080963,0.015557354,-0.09836446,0.020836907,-0.019915331,-0.036974076,0.038984906,-0.11263873,-0.10931623,-0.011456214,0.0749058,0.031065438,-0.03822506,-0.036914364,-0.07024076,-0.03544417,0.13937162,0.020538535,-0.010803367,0.012151887,0.031312965,0.00037351597,0.006464986,-0.02266498,0.008525503,-0.11471363,0.04930202,-0.03698043,-0.030338991,-0.021339944,0.04877274,0.060982544,-0.057710372,-0.09557903,0.005076134,-0.00495755,0.076909296,0.026427606,-0.020186307,0.030825814,-0.03488705,-0.08845806,-0.026087765,0.12793593,0.061269827,-0.038239162,-0.009980227,-0.06867746,-0.030260004,0.03996297,-0.0030930212,0.03454509,-0.0073726103,-0.012616044,-0.0071408283,-0.0054905443,0.11098564,0.0069612176,0.041950047,0.014224592,-0.021462977,-0.101179786,-0.015933465,-0.101221316,0.0367256,-0.02823806,-0.06810014,-0.06921102,-0.02414227,0.032498784,0.011691244,0.061399102,-0.042776417,-0.061445486,-0.03906479,-0.015015857,0.051545914,-0.00771822,0.05941822,0.15679806,0.05836309,-0.022765543,-0.024925867,-0.0009939367,-0.042303775,0.005726696,0.03301687,-0.03219317,-0.014447513,0.052786026,-0.13013992,0.040912576,0.051965993,0.042228464,-0.021882178,0.017964752,0.050143857,0.025687668,-0.0560085,-0.10805765,-0.06688309,-0.014587135,0.0127726635,0.08765681,-0.03845614,-0.039047737,0.015331067,-0.015955087,0.019989356,0.03867527,-0.002740889,0.06552164,0.025655035,-0.078181,0.03278541,-0.06125738,-0.03039132,-0.063966446,0.052117735,-0.029883347,-0.03453441,0.002119231,-0.16104592,2.1837401e-33,0.037759952,-0.032789968,-0.015753921,-0.034972288,-0.028562933,-0.046379972,-0.09420837,0.0016321033,-0.09468039,-0.0047599315,-0.043778323,0.019265998,0.06499819,0.05242275,-0.05151974,-0.04344618,0.035996966,0.06593457,0.040094394,0.030665454,0.040038794,0.09970555,-0.047022,-0.06351497,0.031808734,0.08081556,-0.060146596,0.002126959,0.05641654,0.015390463,-0.004599069,-0.03894147,-0.10218534,0.04880872,0.13611445,0.016127096,-0.020388698,-0.025152907,-0.039590087,0.023074575,0.06899926,-0.034605294,0.011434839,-0.057310957,0.0733037,0.009453567,-0.077970885,0.07208844,0.037718963,0.04806719,0.0584034,0.04236248,0.07602367,0.019531716,-0.093891636,0.029333299,0.048760865,-0.009774034,-0.008856472,0.018965669,-0.06532279,0.07434425,-0.08289167,0.0065401895,0.010337198,0.0036634551,-0.023546273,-0.041320376,-0.016573057,0.08504555,-0.056663096,-0.006274247,0.092068166,0.028744556,0.04782148,-0.01563856,-0.05111691,0.028299436,-0.01687725,0.079302974,0.05530963,-0.007024371,0.010819582,-0.09315856,-0.0931932,-0.018398782,-0.025947258,-0.051588595,0.040910404,0.0628203,0.011977021,-0.046887465,-0.0087463055,0.013989349,0.012550772,-4.2282848e-33,0.08765163,-0.05959592,0.06104948,-0.06790973,0.007852778,0.0555995,0.009500614,-0.043127827,0.069080755,-0.017724134,0.14738372,0.025817899,0.016737634,0.027339995,0.038382795,0.01950908,-0.031724896,0.046988636,-0.0046986635,-0.062140204,0.0207296,0.073860444,0.023690606,0.1004121,0.061242465,-0.03254248,0.05082987,0.025392648,0.030785508,-0.014460945,-0.042919714,-0.03246483,-0.03264676,-0.022840032,-0.08074228,7.240763e-05,-0.07680116,-0.011677963,0.01006789,0.027417447,0.0026441505,0.020547668,0.00795383,0.05275409,0.05908076,0.07153423,-0.061809786,0.028727282,0.010903821,0.0275263,0.07357448,0.004236975,0.03886476,0.023067785,0.061571553,0.07927294,0.003281526,0.019624678,0.03472312,0.021703793,-0.009160506,-0.08102916,-0.0073561333,-0.0043770624,-0.013042584,-0.010839764,-0.060219105,-0.030669698,-0.0041942243,0.0019502548,0.043018434,0.07814724,-0.074685924,0.035479482,-0.037938338,-0.05128107,-0.047612213,-0.09419245,-0.019299041,-0.03676166,-0.04090141,0.014331009,0.03529084,-0.05907507,0.094718285,-0.03382835,-0.011619484,0.06404012,-0.016501041,0.050488498,-0.019372383,0.0067352853,-0.047516163,0.043030463,0.05953797,-4.0823203e-08,0.018770423,0.00188263,0.0070180898,-0.0020186685,-0.010198928,-0.01321478,-0.013559539,-0.06065364,0.0648976,-0.03064064,0.008590292,0.0913205,0.0032350188,0.028531328,-0.011546138,0.03490218,0.0139097255,-0.040055644,0.029096512,-0.016180545,0.025445309,-0.03151256,-0.074825294,0.052853003,0.018884515,-0.035305463,0.042960882,0.08077765,0.021749223,0.037698638,0.0048281,0.006542942,0.019949099,-0.018169435,0.0052743275,-0.008891937,-0.031012569,-0.030420331,-0.045800712,0.055361096,0.035696913,-0.015774677,-0.02543697,0.0071277237,-0.030438162,-0.019646661,-0.0038387333,0.053709902,-0.028966118,0.003231034,0.0035565202,-0.019747332,-0.004614965,-0.057233237,-0.094963886,0.027228376,-0.024373652,-0.028628591,-0.09085646,0.029133944,0.060078427,-1.210728e-05,0.17302233,-0.016560085 +1.14.19.13,"The enzyme, characterized from the the plant Sorghum bicolor, is involved in the biosynthesis of sorgoleone, an allelopathic compound produced in root hair cells. The enzyme inserts a cis double bond at carbon 15. When acting on its natural substrate, (9Z,12Z)-hexadeca-9,12-dienoyl-CoA, it produces a product with a terminal double bond.",384,1.0,-0.02557488,0.016769238,-0.111707084,-0.023278873,0.010985766,0.052042577,-0.09033433,0.048020463,0.03294347,-0.027768856,0.12846683,-0.012435955,-0.06755902,-0.084836155,-0.049055483,0.024984645,-0.014019571,0.05563353,-0.03695591,-0.06048754,0.10060863,-0.02035028,0.05026396,0.017028684,0.05939932,0.0037548267,0.0011964563,-0.013898896,0.0035484089,-0.08987973,0.02339678,0.041386914,0.059019484,-0.03719808,-0.04543942,0.068376385,0.03443306,-0.017317323,0.05151928,-0.0109669855,0.05406676,-0.06986016,-0.004773852,-0.045933615,-0.016065147,-0.06396992,0.002954925,0.04555582,-0.011602848,0.0010224052,-0.026290737,-0.07410733,-0.051951103,-0.024266481,-0.0202151,0.07941863,-0.04963002,0.007126642,0.003912271,0.03225306,0.08525167,0.019672677,-0.03615456,0.054624666,0.032470345,0.008646154,-0.024014967,-0.072969034,0.003655081,-0.07622017,0.0032868343,-0.1236648,-0.018329782,0.041057933,0.012426603,0.07603208,-0.0075686565,0.029781999,0.051142797,-0.041519515,0.02972558,-0.0013594353,0.078219734,0.069771096,0.02469373,0.008484626,-0.016688645,0.09985632,0.04565788,-0.012956154,0.044320006,0.0107746525,-0.07713028,0.021848168,-0.07320357,0.08706383,0.056447722,0.031418905,0.010345769,-0.035047553,0.06839965,-0.02719834,0.0010074025,-0.039107356,-0.008643856,0.040751055,-0.06782431,-0.01718344,0.051101092,-0.03740811,0.008801592,-0.03927575,-0.06201546,-0.045322187,-0.023526412,0.07312391,0.008193272,-0.044216435,-0.05934665,-0.0026136276,-0.012368916,0.03561801,0.0061396887,0.09302414,-0.025074918,0.019226165,-0.117345765,-1.627129e-33,0.037514213,0.06858111,0.020536093,-0.0572912,-0.056658506,-0.009202028,-0.042571433,0.02022896,-0.10537278,-0.041098654,-0.035031486,-0.055668432,0.024955072,-0.00751219,-0.017872108,-0.022120167,-0.00435993,-0.03920081,0.134626,-0.036948644,-0.061979488,0.080715254,-0.1305821,0.02248339,0.07060039,0.025500126,0.010857768,-0.013089153,0.080643125,0.0037668885,0.0830612,-0.03819947,-0.048748557,-0.029126085,0.05369232,0.0025288602,-0.043646317,-0.0050822278,-0.043512683,0.047760732,0.007452254,0.034531888,-0.0032862497,-0.0011077563,0.037738644,-0.0492541,-0.061272964,0.086410575,0.07849036,0.049772326,0.016207376,0.03686046,0.06384666,0.08821487,-0.09176545,0.113334626,-0.007884038,0.047801316,-0.028357906,0.06328731,-0.004388869,0.03039624,-0.013011434,0.04555878,0.0063480735,-0.012114328,-0.038429007,-0.026930561,-0.044285905,0.040846504,-0.0902306,-0.059159283,-0.008493312,0.0029136748,-0.060587358,0.024291331,-0.0328041,0.014356359,0.0021608735,0.024582794,-0.033467624,0.040555365,-0.016236968,-0.095027074,-0.057374105,0.040944614,-0.050789475,-0.056774218,-0.061668642,0.05397531,0.09464883,-0.01615628,-0.050471764,0.017825857,0.03706473,-7.725512e-34,0.05529136,-0.09405779,0.041056715,-0.01854235,-0.02823687,0.05087826,0.024341917,-0.09661443,-0.017765699,0.034158867,0.09820852,0.02431885,0.05587376,-0.066160396,0.032927446,0.005985145,0.021288224,0.1597849,0.025272207,0.019419812,-0.015754122,0.13115653,0.030196965,-0.008014123,-0.035158206,0.005118545,0.041116267,0.012014254,0.04916175,0.080648065,0.06197372,-0.031960998,-0.08333454,-0.025722055,0.02831602,0.03057041,-0.029219601,-0.017318806,0.04422279,0.0064910958,-0.05936849,-0.02564972,-0.019819349,0.054502293,0.061519362,0.04747035,-0.040522564,0.046353407,-0.040664095,0.016235959,0.016112627,0.014616117,-0.016007364,0.061409198,0.024492325,-0.032081172,0.041119065,-0.014823026,-0.085545786,-0.07216301,-0.02530985,-0.0012942685,-0.01685316,-0.063205175,0.052215386,0.027957227,-0.09124387,-0.06694563,0.044901524,-0.034419023,0.04466666,0.045475565,-0.08441902,0.04837967,-0.06272803,0.051903207,0.0028887745,-0.06740524,-0.04933154,-0.0045317984,-0.054259207,0.04481836,0.09188339,-0.008230728,-0.011259238,-0.12163383,0.033351544,0.18430853,0.06663648,0.04239693,-0.021136545,0.0026165664,-0.0756168,0.044699844,0.068198,-3.6423415e-08,-0.06278154,-0.059055224,0.046282303,-0.07905081,0.022445932,0.016901031,-0.0007533127,-0.08443678,0.044873424,-0.018383957,-0.06527219,0.07441656,-0.053262006,0.0040131,0.012944955,-0.06863782,0.017446486,0.024794657,-0.026294952,-0.04510148,-0.071159765,-0.03495054,-0.052838266,7.628574e-06,0.012383323,-0.07429482,0.012204428,0.034177277,0.038032614,0.060254905,0.044341743,-0.03046261,-0.015935365,-0.07115028,-0.05156078,0.006319072,0.003832146,0.007877542,0.06708548,-0.004143145,-0.0054825414,-0.08167249,-0.004697144,0.049209055,-0.0048669083,-0.037255663,0.04038713,0.013553588,0.014368951,0.051544324,-0.044924606,-0.013778932,-0.017143209,-0.039014768,-0.08179136,-0.0048343055,0.016645039,0.01311053,0.025744228,-0.029333217,-0.00016536197,-0.044144742,0.13676472,-0.054826874 +1.14.19.14,"The enzyme, characterized from the plant Calendula officinalis, converts a single cis double bond at position 9 of fatty acids incorporated into glycerolipids into two conjugated trans double bonds at positions 8 and 10.",384,1.0,-0.036933966,-0.015158866,-0.07683139,0.039373104,-0.026605245,0.057984114,-0.09341202,0.031402167,0.04911778,-0.08761126,0.07968144,-0.069051154,-0.089225054,-0.06745049,0.026793849,-0.041030034,-0.038315624,0.05540921,-0.064454965,-0.04060057,0.07845832,0.021560568,-0.028876469,-0.007168183,0.040082145,-0.021287857,-0.044212945,-0.05184003,0.024273023,-0.004824903,0.04530002,-0.0154780885,-0.009734424,-0.038163085,0.014482801,0.03243697,-0.002574273,-0.03480226,0.09266606,0.018493256,0.08917803,-0.06630381,0.017249899,-0.05455236,-0.060121723,-0.036789928,-0.019527854,0.051814824,0.028057959,-0.026580462,-0.029309204,-0.07850923,-0.09174734,0.011354312,-0.018267076,0.070639804,-0.03965204,0.056408715,-0.03642125,0.050053738,0.066460185,0.02248626,0.017398804,0.064073086,-0.07173617,-0.09279101,-0.02711553,-0.039640073,0.050234437,-0.021708304,-0.060793456,-0.010946944,0.0034873115,-0.03351588,0.044158716,0.0418565,-0.11805256,0.013712783,0.07256696,-0.08090842,0.054757345,-0.0044928156,0.033483263,0.049579374,0.01618388,0.012308949,0.021734357,0.086970486,0.032434583,0.010867358,0.07785646,0.01035657,0.00116109,0.029083636,-0.13799895,0.03332384,0.0018757147,-0.004304026,-0.02195691,0.004827547,0.03763152,0.04371032,-0.053049672,-0.085639425,-0.10154677,-0.0011930868,-0.10975671,-0.024640903,-0.0026084916,-0.009286166,0.0004696018,0.0122296335,0.058545157,-0.02528303,-0.021691153,0.054746088,-0.038720604,-0.022928188,0.010209584,-0.0303351,-0.025617398,-0.024742784,0.024102867,0.064571016,-0.051694646,0.040761035,-0.028783519,3.5398488e-33,-0.008895026,0.055699166,0.022273313,-0.020922955,-0.024162253,-0.05350359,-0.14065875,0.019847186,-0.116230644,-0.004520681,-0.010443496,-0.05616341,-0.010555671,0.07191182,0.00981077,-0.00254111,0.06513371,0.0596043,0.14423363,0.005135697,0.014975967,0.08455596,-0.038388062,-0.009975278,0.053239226,0.10116467,0.020416351,-0.006414774,0.051905546,-0.011209695,0.012009123,-0.11637071,-0.06319016,0.042954512,0.11194366,0.05671121,0.01556941,-0.031002497,-0.044665493,0.063135296,-0.017944215,0.0077653877,0.035692666,-0.051921327,0.0645276,0.018716797,-0.0073050098,0.021585789,0.15411776,-0.020895299,0.010854532,0.008922152,0.11397573,0.052880105,-0.09450167,0.044731732,0.019058246,0.07741842,-0.048258208,-0.01533667,-0.032228418,0.031038964,-0.04604608,-0.035181563,-0.023051992,0.0414869,-0.10830663,-0.050164796,0.012908971,0.089387335,-0.05209189,-0.016771557,0.068111464,-0.007464201,0.03823127,0.002148447,0.019539848,0.0028148754,-0.01619308,0.046988565,-0.059765317,0.04978114,0.036790356,-0.070215374,-0.04216369,-0.062492914,-0.07524254,0.035925392,0.0380961,0.07345084,0.02470323,-0.055253208,-0.052001208,0.017939622,-0.0037897066,-4.494812e-33,0.07817568,-0.058611326,0.048987083,-0.032314744,-0.015842417,0.016670685,-0.037850384,-0.05548665,0.039943967,-0.014737016,0.10158157,0.018266354,0.053780448,-0.02399007,-0.03419332,0.0035769462,0.00079522526,0.12171485,-0.04216153,-0.020840457,-0.042911027,0.020689411,-0.028414674,0.06876618,0.035090026,0.053287383,0.05833619,0.07284447,0.01397646,0.023198802,0.023255413,-0.08868028,-0.076310776,-0.009386876,-0.059658192,0.06988595,-0.07282138,-0.0033945695,0.015838537,0.04037478,-0.022299381,0.04934538,0.027081814,0.01509184,0.04760745,0.0074056876,-0.07557543,0.046584938,-0.029370766,-0.053352203,-0.00508358,0.032128938,-0.07121749,0.025881805,0.053338733,0.018573115,-0.0057202745,0.026439715,-0.058726586,-0.073860854,-0.05735211,-0.060492583,-0.015769137,-0.04112281,0.026465828,0.05594885,-0.030955652,-0.03452849,-0.0035335121,0.02042435,0.052991312,0.048109718,-0.03553929,0.04640618,-0.001177727,-0.004550612,0.0013197176,-0.105713725,-0.033847615,0.0010633804,-0.05104288,-0.05065061,0.02238776,-0.078442454,0.014535609,-0.047763474,0.00078513206,0.10486724,0.045726556,0.037069872,-0.0049886955,0.047486607,-0.025942573,0.018684158,0.09349112,-3.4324945e-08,0.027057508,-0.07758641,0.018384043,-0.08528882,-0.032425564,-0.03843233,-0.0018344591,-0.060122292,0.016225208,-0.05884155,-0.06557843,0.035478618,-0.0008781554,-0.0025001497,0.025401944,0.03480609,-0.01782186,0.05314342,-0.026495865,-0.029865142,-0.047379218,-0.039590552,-0.095211826,0.023057379,0.0038632336,-0.08016272,-0.01289781,0.06836277,0.012417945,0.08616849,0.04865021,-0.016074592,0.0017798003,0.003786647,0.015757376,-0.007650718,-0.040699508,0.027697206,-0.010790125,0.07683627,0.102090254,-0.04024432,-0.08439795,0.035793066,-0.014642432,0.019204214,-0.019097371,0.06740793,0.0045123883,0.061996613,-0.02649868,0.042943437,-0.017749704,-0.04663806,-0.09973519,-0.017706983,-0.0035673939,0.014203013,-0.064411305,-0.016423743,-0.04950867,0.008672088,0.18147047,-0.03574245 +1.14.19.15,"The enzyme, characterized from the silk moth Bombyx mori, catalyses a step in the pathway for the biosynthesis of bombykol, a sex pheromone produced by the moth. The enzyme converts a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds. Prior to catalysing this reaction, the enzyme catalyses the introduction of the cis bond in position 11 (cf. EC 1.14.19.5, acyl-CoA 11-desaturase).",384,0.99999994,-0.092294335,0.01352684,-0.08415069,0.03367323,0.03731888,0.039531995,-0.013899797,-0.016058387,0.022109158,-0.038887814,0.06744898,-0.046407714,-0.059424605,0.008987216,0.018073794,0.07663402,-0.0420628,0.014690269,-0.081230775,-0.08704277,0.08811281,-0.027517382,0.054176748,-0.009138077,-0.03186736,-0.05083852,0.015621707,-0.0012546014,-0.01596552,-0.038688857,0.06667013,0.030342909,0.0012977209,-0.0299603,0.021108141,0.038020354,-0.026726615,-0.13022311,0.09754158,-0.0049850103,0.008609494,0.0058262628,-0.08399585,0.00024247314,-0.09041335,-0.039107256,-0.036323905,0.035240613,0.015362523,-0.078266405,-0.01798204,-0.038054455,-0.019852305,0.06454756,0.02127942,-0.012378619,0.011658356,0.0029311292,-0.013066181,0.01766068,0.034243267,0.051515866,-0.006142376,0.01093973,0.024590716,-0.041604415,-0.013843114,-0.01990304,0.02405069,-0.049436316,-0.03919905,-0.06381229,-0.03243795,0.0131927505,-0.0007675927,-0.0052130627,-0.018922083,-0.03530025,-0.013826851,0.0054714754,-0.059844732,0.004514274,0.08372301,0.085269965,0.04007713,-0.014217812,0.015518737,0.044739444,0.007269188,0.07628921,0.029540822,-0.007032959,-0.020913934,0.001442868,-0.07830093,0.071914494,0.024582142,0.026987024,-0.03221835,0.048229907,-0.0018730746,0.018404942,-0.11042792,-0.13922186,-0.12893793,-0.03217304,0.020522965,0.03651517,0.021942902,-0.00957395,-0.058681138,-0.077364,0.03783645,0.043687124,-0.0775796,-0.003119309,-0.040634055,0.0019369998,0.07633786,0.0038626173,0.051522255,0.021169754,0.010751964,0.11409574,-0.015344721,-0.0036015033,-0.13902971,1.1187824e-33,0.05533778,0.09685212,0.0051506553,0.041535147,-0.07300278,-0.05039421,-0.07339284,0.016780661,-0.09534532,-0.0071641714,-0.028667772,-0.039404865,-0.0038425662,-0.017697848,-0.017025033,-0.04951769,0.049843382,0.011107718,0.07340264,0.06785333,-0.03757166,0.05194326,-0.0109824,-0.055036012,0.04596228,0.115868695,-0.10390613,0.031780757,0.0057075494,0.024112977,0.07373721,-0.06969461,-0.04185862,0.09929297,0.030791033,0.06548765,-0.01417308,-0.03853698,-0.1017718,0.017910477,0.017236687,-0.046536915,0.0069610425,0.0022742592,0.029631456,-0.058015067,-0.118966356,0.06874752,0.07626965,-0.005746907,-0.023764826,0.03611319,0.09949188,-0.01742933,-0.06916947,0.035167858,0.040153548,-0.083512045,0.028242802,0.018594079,0.009241246,-0.029646065,-0.035247773,-0.026646288,0.09750591,-0.0333287,-0.040271416,0.026456533,-0.08997852,0.08096292,-0.08126331,0.010322155,0.04044621,0.036695212,0.03661442,0.019204997,-0.007441043,-0.02205468,0.02869415,0.042811193,0.007360337,-0.0044045895,0.030435758,-0.064093,-0.046898108,-0.065982744,-0.084760256,0.03237514,0.06286697,0.119411975,-0.0020641366,-0.111080326,0.04742235,-0.009677313,0.039171714,-2.7930846e-33,-0.0005142152,-0.038301434,-0.08636007,-0.0949871,-0.009117486,0.08385569,0.0347382,-0.07236673,-0.019476512,0.07339548,0.108891614,-0.039345276,0.015910676,-0.009834322,0.009120769,0.051042676,0.056067087,0.08197184,0.051103763,-0.010017532,-0.034026302,0.09604605,-0.00090335455,0.020262238,-0.04649696,0.015092011,0.09676906,0.08389449,0.05178118,0.030555535,0.025476765,-0.06779394,-0.021733338,0.050224643,0.02005241,0.04515657,-0.047532372,-0.042009275,0.051544648,0.07467105,-0.040597882,-0.03921431,-0.03152075,0.010435648,0.017541591,0.019707236,-0.091816306,0.024065457,0.034192488,-0.039021946,0.038120173,0.0958972,-0.04681943,-0.053163894,0.014411887,0.029440813,-0.0016936841,-0.037893716,0.053982187,-0.041782923,-0.04357767,0.023103628,0.0124961035,0.081093594,-0.032493826,0.033025067,-0.0735391,0.0143702235,-0.027550202,-0.013453464,0.07282482,0.020144982,-0.01140742,0.022636812,-0.1279167,-0.098907806,0.020368343,-0.023959331,0.008909376,-0.018341618,-0.00092941156,-0.03963582,-0.014703373,-0.058391467,0.0073377513,-0.05242241,0.017056594,0.09223756,0.009364991,-0.060619593,-0.026172226,0.020164054,-0.01869493,0.09144325,0.08950332,-3.8305824e-08,-0.06517278,-0.0901634,-0.018256593,-0.035364296,0.041405797,0.049836256,-0.02357991,-0.10995322,-0.026596079,-0.043457713,-0.034118384,0.040070545,0.04885102,0.014718653,0.04056023,-0.015716935,0.04858817,0.05110407,0.021452019,-0.0337858,-0.010466478,0.014513742,-0.049852144,-0.037406493,-0.010486894,-0.03925016,0.03431338,0.05600545,-0.0021415357,0.015760574,-0.013910129,0.041169364,-0.036511894,0.032001656,-0.033734005,0.04935086,0.009820435,-0.04970953,0.0015012608,0.031405102,0.015143763,0.0034753159,-0.056961525,0.016306346,0.05458855,0.025861124,0.07212014,-0.0041758367,-0.042218436,0.08272877,0.014591655,0.058980435,0.022920573,-0.01861209,-0.06748452,0.023020575,0.031651568,-0.05380169,-0.04697936,-0.00950538,0.049949918,-0.017559513,0.16071925,-0.078077845 +1.14.19.16,"The enzyme, characterized from the plants Punica granatum (pomegranate) and Trichosanthes kirilowii (Mongolian snake-gourd), converts a single cis double bond at position 12 of linoleate incorporated into phosphatidylcholine into conjugated 11-trans and 13-cis double bonds. cf. EC 1.14.19.33, Delta12 acyl-lipid conjugase (11E,13E-forming).",384,1.0,-0.072389215,0.0026330785,-0.10796927,-0.030664023,-0.06690351,0.0049412963,0.00020308122,0.05255679,0.03282342,-0.03377752,0.072642595,-0.045579966,-0.04394944,-0.014712687,0.010954226,-0.0017249561,-0.017687412,0.06828844,-0.029243976,-0.07515021,0.10042407,0.022637304,0.04701075,0.012228671,-0.052750353,-0.05475935,0.004193511,-0.11146277,0.009458764,-0.070556596,-0.03767921,-0.05769035,-0.055134736,-0.040568978,0.05307632,0.012605649,0.0016634801,-0.01197282,0.056877244,0.019317107,0.13610755,0.012599149,0.0123622995,-0.021591278,-0.02760659,-0.042673703,-0.05133948,0.026643243,0.035504546,-0.01634992,0.020014605,-0.056232873,-0.10429585,-0.0027459208,-0.04991482,0.11429251,-0.07882857,0.0054237004,-0.020256912,0.08962116,0.05018612,0.052308485,0.044471566,0.03669839,-0.04110039,-0.086778454,0.0065523046,-0.02917968,0.05560957,-0.04390623,-0.06654869,-0.05946598,-0.025842179,-0.027822873,0.016675929,0.058637798,-0.024998521,0.035263047,0.03858274,-0.085149765,0.016646478,-0.007823108,0.07564001,0.047487598,0.07824544,-0.005588779,0.0018664598,0.038213328,0.05821995,0.020770317,0.07061322,-0.0050929356,-0.004731119,0.047652613,-0.10690653,0.03374171,0.026577376,0.040810004,-0.04748954,0.01774838,0.05567476,0.0031616387,-0.0058121984,-0.10810055,-0.064189136,-0.021329712,-0.046904188,-0.022849567,0.0430566,0.027457902,-0.030554933,0.005525583,0.09313805,0.0043915072,0.028178278,0.045873877,-0.019343322,-0.029179404,0.047276348,-0.07597603,-0.03791735,-0.0567362,-0.018014329,0.046888903,-0.042497672,-0.0037069598,-0.09115804,5.0552976e-33,0.055850647,-0.0036286302,0.05189996,0.017336776,-0.11345682,-0.014446101,-0.13063148,-0.056328803,-0.13245979,-0.030424995,-0.0426501,-0.079346955,4.1599185e-05,0.057673037,-0.04831404,-0.000310852,-0.0057141893,0.07395949,0.14238322,-0.047043264,-0.026555045,0.11969286,-0.042271663,0.04402513,0.08154015,0.06875725,-0.06427885,-0.04590642,0.022420803,0.024672644,-0.00039060728,-0.106536135,-0.059899185,0.09050478,-0.0029437796,0.03684303,0.021759102,-0.06907798,-0.028807946,0.014710207,-0.013240096,-0.030081388,0.046923954,-0.03001593,0.037800863,-0.007664053,-0.075956605,0.114952356,0.06921459,0.015098891,-0.07316584,0.0019755345,0.08615962,0.09926,-0.12823075,0.05092838,0.06418179,-0.0030817902,0.03767936,-0.02529797,-0.0087105585,0.058113534,-0.07351421,-0.008921309,0.092387065,0.029556906,-0.08924621,-0.031844873,0.01931831,0.10778177,-0.04957537,-0.010928844,-0.05574721,0.0022117738,0.05165979,-0.074787736,-0.041762456,-0.008635248,-0.054548148,0.11503899,0.025897156,0.011419603,0.014048092,-0.056053422,-0.01545591,0.0045841453,-0.0031800333,0.0462816,0.066003054,0.037348773,0.047213856,-0.011332851,-0.027058952,0.057918154,0.018967248,-3.8997047e-33,0.034542345,-0.056172237,0.030575933,0.019169193,-0.019782145,0.0010545508,-0.014181427,-0.061911404,0.018919168,-0.032328214,0.08127456,-0.012987056,0.056084298,-0.013534994,0.0052763163,-0.0018718498,0.0026319304,0.09824573,0.0322471,-0.035359085,-0.06700775,0.012623431,-0.0216196,0.06572664,0.01895974,-0.013670128,-0.0041261637,0.027662853,-0.011392742,0.06293634,-0.006710875,-0.03902122,-0.046742283,0.011342495,-0.070583425,-0.052767724,-0.023440009,-0.003942929,0.004302679,-0.008165182,-0.044104572,0.012787517,0.08478834,0.011987921,0.02116664,0.06981542,-0.038797297,0.027439635,-0.06112231,0.031148309,0.014039529,0.031881053,0.0512228,-0.01170462,0.0605147,-0.016218662,0.0161434,-0.003443579,-0.026199864,-0.07282515,-0.013584336,-0.034964748,-0.06431987,-0.05675023,0.025545934,0.09949529,-0.004936233,0.041861754,-0.010826574,-0.0127506,0.05688127,0.08812257,0.0042386986,0.031020315,0.0028624812,-0.029961094,0.037803933,-0.04788145,0.029820595,-0.022940757,0.007827874,-0.009806176,0.058942594,-0.09733096,0.017526431,-0.001344374,-0.015132714,0.14947776,0.0878394,0.072796896,-0.031862363,0.021794835,-0.035728164,0.031774852,0.07705653,-4.4961922e-08,-0.011147348,-0.043567035,-0.019605711,-0.0606691,-0.021945596,0.000159416,-0.00049201184,-0.080182426,0.025857406,-0.0491047,-0.016291585,0.058372375,0.013192359,0.011548487,0.03341198,0.05295367,0.059339385,0.06478409,-0.024234023,-0.03131163,-0.0484217,0.018617986,-0.099886835,0.045027204,-0.0034265232,-0.016187,0.006834805,0.009800883,0.0189018,0.06764833,-0.024955254,-0.016077,-0.024975743,-0.05891974,-0.030994106,0.044042483,0.017186204,-0.0096197445,0.055162977,0.055332575,0.041156456,-0.017442606,-0.008635908,0.0016938426,-0.022096662,-0.0046757315,-0.007358222,-0.0007165311,-0.014119096,0.028280567,-0.030998657,0.022334525,0.030528294,-0.06754995,-0.13358657,-0.03959785,-0.00068080804,-0.012825462,-0.07055582,-0.0068393922,-0.014085389,0.0046183486,0.19460422,-0.017047124 +1.14.19.17,"The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids [1]. The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide [2]. Unlike EC 1.14.19.29, sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain [4] and requires an external cytochrome b5 [3]. The product serves as an important signalling molecules in mammals and is required for spermatide differentiation [5].",384,0.99999994,-0.09462255,-0.03608867,-0.08724131,-0.06521412,-0.0007449654,-0.026482776,-0.032469373,0.062447824,-0.021528771,0.0070566926,0.04808959,-0.06108964,-0.12118769,0.074383505,0.028340591,0.07980618,-0.05178592,-0.016972385,0.033512414,-0.018445225,0.07058141,-0.027709277,-0.05435716,0.049820226,0.010115338,-0.044149403,0.02302142,-0.0022337195,-0.05712066,-0.04055737,-0.029966684,0.016130475,0.0286803,-0.089114554,-0.009694577,0.074419804,-0.046909314,0.018662361,0.06397906,-0.025408756,0.066862084,-0.026392825,-0.04457798,-0.0046077096,-0.026376748,-0.0027873865,-0.021103635,0.09275411,0.03843063,0.007995981,-0.028005686,-0.0513895,0.009959427,0.0065016723,-0.008983491,-0.0018574995,-0.06316541,0.041187964,-0.05578416,0.055450864,0.006716025,0.016544802,-0.025810871,0.012937316,0.007348251,-0.056044467,0.00059134886,-0.06827731,-0.009174594,0.014115974,-0.0021777514,-0.06966741,0.03752634,0.026690347,-0.025272908,0.09910875,-0.04696943,0.010782977,0.0027361736,-0.083723135,0.03801763,-0.061546233,0.05257279,0.0965592,0.039260145,0.004261438,-0.01579101,0.0022583038,-0.045456164,0.039302602,0.038461413,0.03245342,-0.029240975,0.026430095,-0.12501512,0.08502454,-0.028461438,0.035314005,-0.07083083,-0.003759398,0.00643895,0.04880593,-0.037653103,-0.07896316,-0.042997044,-0.001893413,-0.024383293,0.00073461834,0.0127504915,-0.04190585,0.027576935,0.028404493,0.047092866,0.03243402,-0.021117963,0.0024524948,-0.042706523,-0.03395331,0.011148726,-0.03510268,-0.023054646,0.017947195,-0.028448027,0.01649622,-0.039338887,-0.03352699,-0.04354813,2.7818636e-33,0.08329257,0.015659586,0.043357965,0.054151073,-0.10287832,0.04537525,-0.05228104,-0.024323355,-0.10205132,-0.013562541,-0.054634705,-0.061198536,0.036617115,0.028369626,-0.0046008904,0.01998173,0.032406442,0.0018726863,0.15045151,0.06671393,-0.008506808,0.038622584,-0.108432606,-0.091765806,0.06285035,0.07850489,-0.09251807,-0.028277189,0.035090756,0.010549237,-0.0077751144,-0.009123239,-0.09551002,0.035109542,0.0785543,0.005929801,-0.03349633,-0.03223693,-0.09148533,0.04904443,0.043657564,-0.05333027,0.027430074,-0.033468384,0.022073755,-0.02260225,-0.09415027,0.035422295,0.07238047,0.03386852,0.036338575,-0.013378173,0.09415517,0.022029823,-0.067448996,0.04778924,0.035846688,-0.045919474,-0.02279088,0.049990486,-0.010061709,0.05827305,-0.06841593,0.032170914,0.024668995,-0.010241048,-0.063881986,-0.09065816,-0.115982175,0.045549043,-0.0338884,-0.027413314,0.105577365,-0.031683914,-0.065094106,-0.03408897,0.0036673842,0.061437313,0.017388051,0.048474006,0.052585937,-0.052470658,-0.028814964,-0.05380791,-0.044566333,0.036463145,0.030468723,-0.028592126,0.04453687,0.022200057,0.0068454645,-0.123392,-0.02954525,0.0039668228,0.02173089,-4.5768497e-33,0.043870874,-0.092388764,0.04292746,-0.05680151,-0.06092936,0.13327287,0.09886142,-0.056653254,0.0037246356,0.0096619455,0.060626164,0.0450439,0.020227307,-0.011446086,-0.033873104,0.0631753,-0.006554685,0.031361595,0.030059207,-0.08708355,0.009253105,0.17211244,-0.0046440535,0.10343772,0.0518409,-0.036211982,0.023081338,0.052412577,0.020137558,0.01475678,-0.05730902,0.033685777,-0.031153962,-0.018869944,0.03338026,-0.022924487,-0.06328298,-0.007342733,0.04097455,0.014245364,-0.15502137,0.06863408,-0.0004900994,0.08925089,0.115910985,0.12332051,-0.07663373,0.07769826,-0.01570578,0.050758865,0.0040028784,0.033134975,-0.042459834,-0.039964642,0.019616175,-0.01843369,-0.030411907,0.017751338,0.029243184,-0.022827623,0.006947422,-0.032635886,-0.042459767,0.042331036,0.0043555587,0.08223404,-0.068294674,0.039836198,-0.0054640104,-0.002613814,0.014197722,0.002681042,0.00080989016,0.04912917,-0.045539178,-0.023045732,0.011395101,-0.053979237,0.019193338,0.028170926,0.020453878,0.0029521699,0.033409506,0.018255815,0.054765873,-0.02150033,-0.024919052,0.040360387,0.036585357,-0.010001237,-0.018263938,0.033155285,-0.03759214,0.027651163,0.09296935,-4.516693e-08,0.047453262,-0.04175637,-0.015536329,-0.100108095,-0.027173422,-0.050438523,0.0066403206,-0.06856335,0.057500888,-0.09823309,-0.10683501,0.042609926,0.0052105873,0.08676654,0.0699665,0.045839027,0.07268694,-0.03766853,-0.023660349,-0.019470612,0.00013717754,-0.038040634,-0.12048263,0.02353707,0.02286867,-0.018482294,0.04199425,0.01681497,0.032555923,0.041001584,0.043088038,-0.0057381974,-0.01888355,0.037513673,0.0691018,0.028740885,-0.07405446,0.0023777436,-0.017759353,0.07119153,-0.020015245,-0.10520785,-0.004947995,0.0039825044,-0.030022953,-0.025817115,0.021854691,0.025154795,0.038237765,0.05480365,-0.04798272,0.03134112,0.010865994,-0.063499734,-0.07002089,-0.025604019,0.012879331,-0.026446225,0.0017795721,-0.05298076,0.0044831703,0.029475046,0.14588869,-0.043580495 +1.14.19.18,"The enzyme, characterized from the yeasts Kluyveromyces lactis and Candida albicans [1] and from the diatom Thalassiosira pseudonana [2], introduces a trans double bond at the 8-position of sphingoid bases in sphingolipids. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase [3]. The homologous enzymes from higher plants, EC 1.14.19.29, sphingolipid 8-(E/Z)-desaturase, act on phytosphinganine (4-hydroxysphinganine) and produces a mixture of trans and cis isomers.",384,1.0,-0.0760786,0.0043604122,-0.11650982,-0.040004227,-0.013004988,0.027107233,-0.044594716,0.052038006,0.031921078,-0.0042763883,0.075792566,-0.05112039,-0.10172946,0.047277015,0.023826689,0.030431861,-0.072001524,0.062324595,-0.0039693834,-0.010646588,0.15957206,-0.010979449,-0.042325158,0.039585494,0.04929535,-0.02102359,0.006293893,-0.011169432,-0.028160201,-0.107896686,-0.0028261573,-0.014377215,0.025863256,-0.02724645,0.024487602,0.02110275,0.029437,-0.044119496,0.12329084,-0.0091803465,0.057410005,0.004274405,-0.02211455,-0.005902167,-0.06658936,0.016995909,-0.00405395,0.101703994,0.021908388,-0.07472523,-0.0011523638,-0.002903197,-0.00311646,0.044317257,-0.054268416,0.043306056,-0.004644363,0.039901547,-0.032422844,0.04416126,0.06768307,-0.01094435,0.013932341,0.034733362,-0.08489983,-0.07851736,-0.006962415,-0.03476525,0.063719645,-0.023834184,-0.06692529,-0.09226248,-0.017548334,0.037675794,0.03234817,0.09042431,0.0045961016,-0.013748527,-0.028271263,-0.062245157,0.045981593,-0.034698598,0.09129073,0.09579119,0.023757836,-0.030607525,-0.027120624,0.042083222,0.007623094,0.015670976,0.07341523,0.0061180885,-0.008153464,0.050851718,-0.05033577,0.10404929,-0.013385664,0.076550335,-0.025072943,0.0033529368,0.04138505,0.03132346,-0.04038469,-0.07520448,0.012221268,0.025659624,-0.0006316908,0.01653782,0.002541549,-0.018385246,0.006948283,-0.0026957914,0.03571551,0.0017590785,-0.048873305,0.0012883951,0.0017437027,-0.009469171,-0.01855754,-0.0937333,-0.0326208,0.022886036,-0.0011384058,0.016976494,-0.02025462,0.017547978,-0.07850583,2.6290892e-33,0.029683124,0.057246495,0.017190088,-0.040976245,-0.092867896,-0.07751099,-0.06818907,0.02548773,-0.10745585,0.024406198,-0.06791141,-0.039710212,0.017539091,0.044893757,-0.06473834,0.000119302356,0.061103497,0.01755802,0.083056,0.063313074,-0.031050231,0.06569668,-0.10985076,-0.047746547,0.07544182,0.081002355,-0.058336947,-0.011274949,0.025613394,-0.026927648,0.012622573,-0.0649467,-0.07045423,0.056831487,0.0876872,0.019209359,0.010265859,-0.0051204213,-0.045973595,-0.004902396,-0.0006462106,0.0033098892,0.001960765,0.0015235572,0.046251208,0.046260547,-0.104929745,0.031362645,0.05597032,0.07480633,-0.0076309424,-0.0036218744,0.06540962,0.08314198,-0.05321293,0.025419263,0.032490723,0.01336325,0.06902073,0.0049927435,-0.067489594,0.05587109,-0.07424874,-0.009429282,0.062483326,0.007459435,-0.07744927,-0.06422331,-0.06892001,0.067160405,-0.08559112,-0.021099834,0.024634564,-0.0010692453,0.01622213,-0.028870597,-0.05423687,-0.032430395,-0.0003883944,0.092503466,0.024312729,-0.047530122,0.00051359285,-0.10677919,-0.08252155,-0.014021656,-0.037606556,-0.024714803,0.039966058,0.022572808,-0.00093817845,-0.05725958,-0.038462948,0.05206232,0.06381499,-3.9500008e-33,0.113607936,-0.06468233,0.033857565,-0.06710758,-0.04839873,0.07780954,-0.0057915878,-0.03612241,-8.597201e-05,-0.0054634046,0.074782684,-0.00936057,-0.015505959,-0.008742261,-0.044604342,0.0075016934,0.0036261433,0.08466871,0.03053621,-0.0055918167,-0.008031298,0.19820261,-0.06055891,0.11517855,0.07711751,-0.044238474,0.05233348,0.091828525,0.0063647525,-0.0022353034,0.004873695,-0.058085233,-0.017437525,-0.025343794,-0.02773577,0.015666489,-0.08171152,0.0112915775,0.00959746,0.010569246,-0.037616756,0.0061827865,-0.018210916,0.041557554,0.11593928,0.10715109,-0.09867404,0.07302493,-0.014183227,0.008156493,0.004120809,0.056755226,-0.010982937,0.013485603,0.07016053,-0.005746261,-0.038495332,0.028019309,0.00056657003,-0.02756241,0.00944975,-0.088777885,-0.015684374,-0.024419209,-0.013824713,0.057741705,-0.065471336,0.022218918,-0.010318328,-0.018830417,0.02171593,0.05079774,-0.07759183,0.037094835,-0.0730162,-0.034286737,-0.04658238,-0.11654356,-0.030923251,0.015582952,-0.011529238,-0.01433353,0.07476617,-0.015623467,0.055389702,0.019534348,-0.018644175,0.04289953,-0.006411159,0.034525562,0.020615831,-0.02792531,-0.027618086,0.06294855,0.051498033,-4.6531326e-08,0.05531446,-0.0057332693,0.04457609,-0.08881094,-0.055811446,-0.03841622,0.007417193,-0.061486717,0.037465505,-0.06047918,-0.08343684,0.077120245,-0.01656486,0.063103735,0.08733755,0.0014654287,0.008809889,-0.011555397,0.0013981118,0.01418723,0.017009828,-0.04280066,-0.121907055,0.032196727,0.04724859,-0.037469316,0.077564016,0.02869331,0.06295104,0.043694362,0.0268776,0.005313444,0.0069220904,0.04129867,0.047057047,-0.022664022,-0.06696473,-0.048158605,-0.017593857,0.009333702,0.013968446,-0.11841742,-0.011756905,0.008998619,-0.05727554,-0.0033346135,0.042294536,0.013880884,0.03096745,0.004894125,0.028806688,-0.008735744,-0.02017904,-0.037911054,-0.10808808,0.021364702,-0.0063854354,-0.00082870707,-0.0625632,-0.04131877,0.0032184054,-0.028513553,0.15410282,-0.05041311 +1.14.19.19,"The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product. Similar triunsaturated sphingoid bases are found in some marine invertebrates. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.",384,0.99999994,-0.089131534,-0.0049016825,-0.09910181,-0.09478611,-0.012133277,-0.018386025,-0.03668047,0.06112101,-0.0026178444,-0.013238787,0.053575378,-0.10782337,-0.10112314,0.015427575,0.0052805264,0.08671301,-0.03299868,0.03811238,0.034190524,-0.035870053,0.14914133,0.04395921,-0.05135529,0.0017941311,-0.0014070969,0.018208021,0.028358487,0.009346653,-0.0153458305,-0.113934785,-0.053718932,0.043406814,0.021385448,-0.044006165,0.08600309,0.033716984,-0.048827343,-0.043715935,0.06440666,0.041369937,0.054113347,-0.0049615777,0.02472335,0.0019513873,-0.030721936,-0.035419766,0.0034557255,0.10818322,0.0042635016,-0.04691401,-0.027166445,-0.028414791,-0.063389845,0.07651915,-0.035511,0.07720957,-0.022714477,0.01619081,-0.0578083,-0.005488899,0.07212445,0.0667427,-0.0041458188,-0.024066241,7.9572106e-05,-0.045803163,0.014511737,-0.054180965,0.018892042,-0.04039918,-0.02978358,-0.07105494,0.012710603,0.04510772,-0.009383985,-0.004207183,0.021860076,0.017697606,0.010938754,-0.03325476,-0.015887627,-0.029407166,0.09076506,0.09089139,0.054658003,0.0054773637,-0.00748444,0.019600434,-0.016753634,0.03699148,0.038535308,-0.0021209163,-0.049056474,-0.060924746,-0.097858585,0.074959666,-0.021919321,0.08360361,0.055639286,-0.010487038,0.050312832,0.020444307,-0.012473123,-0.14359309,-0.057384074,0.03239613,0.0057617174,0.06317105,0.05441935,-0.040165562,-0.05508677,0.04665682,0.0241144,0.034504194,-0.05430727,0.053862683,-0.015142366,-0.07372987,-0.015173181,-0.07994418,-0.028194861,-0.008851329,0.039185572,0.100655325,-0.0027172873,0.031620678,-0.10859657,1.3939199e-33,0.06695218,0.040581,0.022840187,-0.06286131,-0.14043169,-0.04508407,-0.056484763,0.022029113,-0.10422312,0.027210008,-0.08680852,-0.0011481426,0.009407153,0.059472118,-0.019685352,-0.010905018,0.034945924,-0.0077993255,0.054256447,0.03704964,0.00016354429,0.09962786,-0.10987109,-0.048424996,0.040291823,0.09400097,-0.023107223,-0.010625588,0.0046840226,0.01993444,0.01704542,-0.06985209,-0.03791549,0.03804856,0.084398165,0.017781105,-0.01181701,-0.013628735,-0.06825247,0.05513455,0.043574717,0.014409234,0.038222134,0.012707226,0.07809411,-0.04348953,-0.07244451,0.05919575,0.09110202,0.02900545,0.00085661793,-0.011138463,0.05455243,0.0038040217,-0.048966583,0.04649946,0.0166455,0.0136135025,0.019376662,0.023685932,-0.052125845,0.0050230036,-0.07522696,-0.0019101404,0.024685364,0.03808928,-0.040919546,-0.12124687,-0.048153277,0.04580487,-0.060360495,-0.031876568,0.09373791,0.006393153,-0.005946422,-0.03599768,-0.04719537,-0.029082544,-0.023779301,0.030188186,-0.0141295595,-0.036670517,-0.0022614405,-0.103042096,-0.06925304,0.004444216,0.013164827,-0.05392546,0.021619491,0.0749199,0.038411517,-0.07598507,-0.08869082,-0.012198275,0.08260666,-1.35852975e-33,0.053476967,-0.10214097,-0.01902936,-0.06216425,-0.03211475,0.04643666,0.006355414,-0.008927077,0.017841049,0.041429024,0.055501875,0.0014343443,-0.039242994,-0.07386978,-0.021854483,0.02305702,0.07411554,0.059069134,0.029595533,-0.03536634,0.0033215121,0.13784094,0.008386041,0.057257675,0.007466101,0.022047935,0.0014928654,0.098035716,0.023943499,-0.0012224532,-0.054657724,-0.013596432,-0.0024591784,-0.034549877,-0.050081316,0.011709687,-0.10192882,0.047719564,0.01950824,0.0057695797,-0.063583985,-0.019433059,-0.023148622,0.09787648,0.091067806,0.07235066,-0.061008196,0.03590238,0.0067426516,-0.008642212,0.056753922,0.026679479,0.073139705,-0.038509075,0.06010324,0.028695522,-0.07138975,0.002933016,0.006926022,-0.0074938373,0.029212365,-0.061200988,0.020604275,-0.012243844,0.029904155,0.08566746,-0.03791557,0.09049707,-0.030911146,0.028028209,0.029174438,0.05802925,-0.09095964,0.04327165,-0.07976382,-0.07302582,-0.07600304,-0.055992875,0.0055903434,0.020247651,-0.03434811,0.019121248,0.027985524,-0.059379097,0.05162195,-0.02137894,0.006858742,0.060490254,-0.007472497,0.010766676,0.006882707,-0.01056104,-0.08394145,0.042503733,0.037865598,-3.6959275e-08,0.067687385,-0.05209132,0.030808346,-0.013277196,-0.052134365,0.0036730296,0.023003755,-0.004808493,0.01847345,-0.050642382,-0.0796141,0.073501326,0.024641639,0.011898745,0.11425561,0.0454468,0.061585907,-0.028671136,-0.041466992,-0.037394024,0.023291674,0.008898205,-0.08853596,0.02799272,-0.029504515,0.020233162,0.079495244,0.018661963,0.06457632,0.063780464,-0.0050886725,0.016196234,0.005115584,0.027702611,0.028294358,0.0026934652,-0.033634886,-0.010666862,-0.039638888,-0.00044946995,-0.02091455,-0.05376897,-0.04261567,0.032714836,0.01695639,0.02108431,0.06648541,-0.019383531,0.05191729,0.024308896,0.029372172,-0.025066007,-0.039443437,-0.053773366,-0.13224812,0.038576093,0.018245181,-0.048768874,-0.059007794,-0.037691604,-0.006905906,0.0066319923,0.15531434,0.016386583 +1.14.19.20,"This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Delta7-sterols, to yield the corresponding Delta5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound.",384,0.99999994,-0.08012635,-0.019189382,-0.12385055,-0.005771057,-0.03801387,0.059058353,-0.073955625,-0.0048390627,0.046117373,-0.01104504,0.04450302,-0.053603135,-0.16539744,-0.028088983,-0.0058402102,-0.0089916205,-0.07870392,0.020040873,-0.0024652444,-0.0894628,0.051091976,0.008866159,-0.018210975,-0.0012600647,0.012262843,0.03006652,0.03008548,0.0142391175,0.026806151,-0.15068781,-0.013936863,-0.054996327,0.026820764,-0.025932096,0.00021197234,0.06432887,-0.020102706,-0.06727004,0.009871518,-0.0089818295,0.049875956,-0.032267414,0.02558708,-0.03627925,-0.037063908,-0.034832854,-0.022962516,0.03181134,0.040657055,-0.035150122,0.01773759,-0.11308511,-0.0362953,0.011972157,-0.04111428,0.021568319,-0.024434146,-0.054851115,0.0035910772,0.00758286,0.06458382,0.023326358,-0.023475057,0.043487806,-0.094690375,-0.06521981,0.03615595,-0.044923354,0.0036794564,0.017788816,-0.05257896,-0.031614855,-0.06521501,0.090169854,0.02424163,0.018361326,-0.046319507,-0.079638414,0.060486104,-0.040766675,0.07401683,-0.00046418732,-0.012146407,0.111670464,0.038917545,0.0028047478,-0.048871808,0.052388396,0.08868599,0.007417708,0.09937462,0.011439359,0.0035773627,0.0011806596,-0.112900734,0.076672696,0.0140554765,0.04342325,-0.022951698,-0.045263387,0.044813577,0.05497635,-0.046897892,-0.021589223,0.013744617,0.015934521,-0.022299128,0.052705877,0.03114495,-0.05363244,-0.03322339,-0.032269206,0.06870222,-0.0016258266,-0.009775195,0.008286973,0.034726128,-0.039297603,-0.029598327,-0.045980528,-0.024100292,0.014683042,-0.00053814147,0.031114811,-0.008558796,0.014390066,-0.096643776,-6.859291e-35,0.074274935,-0.013714517,0.02234711,0.046580035,-0.023422588,-0.017003318,-0.0051743384,-0.00016685008,-0.06890063,-0.055574562,-0.07262542,-0.06299977,0.012655873,0.047149498,0.027187418,0.0064671515,0.0499535,0.031929772,0.04645654,-0.044563815,0.010004196,0.098254114,-0.057852905,-0.02008532,0.0391028,0.051806618,0.0036376663,0.016411854,0.035166048,0.009165055,-0.032811966,-0.030347113,-0.056972608,0.022891317,0.14743295,0.044781607,0.013552918,0.007883018,-0.029627275,0.078107454,0.07298724,0.01373502,-0.044373624,0.020387746,0.041764658,-0.003235889,-0.07361126,0.061998975,0.12620051,0.045374345,0.029678605,-0.0026442115,0.065691665,0.049763646,-0.048196882,0.09864238,-0.054558992,0.06464284,0.0052965838,0.009879008,-0.009645186,0.11209118,-0.06812654,0.07100028,-0.0032819456,0.026897654,-0.008023255,-0.09156466,-0.07681717,0.07664562,-0.047331158,-0.034822375,0.010561087,0.0068963016,0.066152245,0.026571471,-0.06746845,0.0065164836,-0.009419115,-0.023979168,-0.061846476,-0.11667676,0.01850391,-0.018461974,-0.027033294,-0.01378985,-0.016942142,-0.038315408,0.020400364,0.007414598,0.026144182,-0.047557186,-0.07348987,0.08117353,-0.021592725,-2.3094038e-33,0.07757956,-0.12662718,0.10813366,-0.048170514,-0.08575076,0.063766755,-0.012270514,-0.074119106,-0.0022824386,-0.024117183,0.020637661,0.04430467,0.056532897,0.028087556,0.06396316,9.585023e-05,-0.030252647,0.03937304,-0.009533675,-0.017346708,-0.05939615,0.041129004,0.009193746,0.15398549,0.02698643,0.026015047,0.07203153,-0.006601055,0.038428098,-0.021757279,0.0008988223,-0.07526722,0.008723191,-0.036397595,-0.10899033,0.0025186397,-0.015876362,0.017885711,0.038062252,0.00045346073,-0.018798774,-0.016043132,-0.027165622,-0.058660533,0.028328309,-0.0028143374,-0.026100012,0.026541842,-0.039928973,-0.05204793,0.0066520567,0.019236246,0.031219527,0.035200577,0.02515628,0.01575491,0.02102807,-0.011592937,0.1013897,-0.039729744,-0.020381177,-0.02457297,0.017296307,0.011048772,0.072652146,0.07471291,0.036461096,-0.025508607,0.0077709313,-0.08918143,0.051480394,0.045885455,-0.02088839,0.08056248,-0.017145012,0.0035785746,-0.005135293,-0.103591844,-0.0012961953,-0.036059704,-0.05150489,-0.022253076,0.064606465,-0.06676535,-0.08595119,-0.071436524,0.050425358,0.091288336,0.058369417,0.04812678,-0.0067330487,0.011314975,-0.07930513,0.03796523,0.10912355,-3.5663156e-08,0.013883821,-0.022806475,0.04856192,-0.089411646,-0.076082036,0.013549406,0.058695648,-0.014634844,0.07399635,0.002893841,-0.026499862,0.086109824,0.07234457,0.034036607,0.009374991,0.029869562,-0.023672117,-0.030691465,-0.014015204,-0.052306022,-0.030486932,-0.036377348,0.024550159,-0.025011647,0.0065249647,-0.10560631,-0.01131067,0.11134686,0.010758584,-0.043141976,-0.026107127,0.011838916,0.045535877,0.010828559,0.027719855,0.07281813,0.021578504,-0.12311748,-0.011448625,0.0935761,-0.0033786662,-0.055032533,-0.008676096,-0.019810883,-0.025771458,-0.007784114,0.060205843,0.06765761,0.019182356,-0.005226116,0.010014533,0.011779221,-0.03860146,-0.05469031,-0.11629849,-0.040143173,-0.07109566,-0.02227906,-0.013435422,-0.023234183,0.04170458,-0.0003936071,0.14570974,-0.0068681356 +1.14.19.21,"The enzyme, characterized from several organisms including the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the ciliate Tetrahymena thermophila, is a Rieske oxygenase. In insects it participates in the the biosythesis of ecdysteroid hormones. The electrons are transferred from NAD(P)H via an electron transfer chain likely to include ferredoxin reductase and ferredoxin. The enzyme differs from regular desaturases, such as EC 1.14.19.20, 7-sterol 5(6)-desaturase, which are cytochrome b5-dependent and contain the three His-boxes that are typical to most desaturases.",384,0.99999994,-0.090657175,0.023253031,-0.05453988,-0.038680516,0.026484488,0.02809366,-0.03607305,0.016739022,0.0027900876,-0.0009402364,-0.002401301,-0.08911436,-0.077827565,-0.012602603,-0.04107061,0.032831386,-0.0386554,-0.005556337,-0.033771843,-0.1185949,0.09658631,0.04122598,-0.00865311,-0.018994259,0.034169134,0.011120832,0.005052918,0.0018586891,-0.05443814,-0.12782486,-0.03413862,-0.06868516,-0.020381251,0.020062862,-0.0031417664,0.09436146,-0.06070681,-0.089585975,0.022875708,0.022781678,0.0703594,0.032719973,-0.076217584,0.010409098,-0.086581245,-0.05844541,-0.01781695,0.03274229,0.04732663,-0.052135188,0.007545416,-0.030541068,-0.0006574664,0.105056845,-0.014602259,0.0011277581,0.035696764,-0.049167976,-0.055438496,-0.10184398,0.05106813,0.023336032,0.029713588,-0.0036968112,-0.015970107,-0.01703955,0.015312945,-0.067970894,0.04067259,-0.101120844,-0.09803134,-0.013930162,-0.023993796,0.04693897,-0.030197782,0.021249237,-0.023841303,-0.015874622,0.010462862,0.0009450352,-0.017716477,-0.008378238,0.05588474,0.08446819,0.095223434,0.023290493,-0.019525038,-0.01009764,-0.062286165,0.01064794,0.026900657,-0.041631922,-0.0031742514,0.061213676,-0.09098883,0.04547225,0.0016751713,0.024489926,-0.028232494,-0.024542186,-0.0076100645,0.10477148,-0.023254998,-0.05597576,-0.038486026,-0.015624631,0.051961165,0.036168877,0.0032335469,-0.047077853,-0.033448495,-0.036430277,0.08423316,0.09153981,0.006771347,0.0345485,-0.03511972,0.017626284,0.068908155,0.00227358,0.041574303,0.021338692,-0.008785633,0.015101868,-0.006040226,0.031862926,-0.16242991,2.8094423e-33,0.084555,-0.0030246668,-0.020233415,0.04926481,-0.047822114,0.03363312,-0.08362256,0.09019437,-0.031273734,-0.044906907,-0.09128751,-0.006000694,0.04987717,0.01582699,-0.0064934036,-0.0110946875,0.008352798,-0.002053763,0.082487606,-0.0044395053,0.01652287,0.05906509,-0.07966686,-0.050795794,0.06663409,0.07220274,-0.104889065,0.04532699,-0.010379993,0.017731948,0.02859461,-0.07184202,-0.038365964,0.10106851,0.07841811,0.025885312,-0.026920956,-0.017014809,-0.024553021,0.04644029,-0.023952693,-0.02784515,-0.0028456473,-0.078326546,0.0446974,-0.061464276,-0.09822329,0.07710641,0.08815644,0.06733705,0.06566955,-0.0064217504,0.14300916,-0.06343645,-0.015530188,0.03123654,0.006661467,-0.030434035,-0.005593546,0.05226575,-0.011657525,0.10280692,-0.036295712,0.023069147,0.08429124,0.042323403,-0.06825848,-0.04242329,-0.10149125,0.07423571,-0.073208235,0.016368376,0.046309266,-0.010620088,0.0312957,-0.020276261,-0.06301829,-0.022840608,-0.026638748,0.02102411,0.018433118,-0.0908588,-0.039501306,-0.081845,-0.048724573,0.014083957,0.019736994,0.0042447336,0.06729949,0.07318705,0.03972544,-0.07677824,-0.05061405,-0.01641807,0.043760948,-3.4833645e-33,0.03393233,-0.044399723,0.015364846,-0.05354281,-0.040991336,0.12817404,0.04487091,0.0019914003,0.046163652,0.03389362,0.048074238,0.049204737,0.0023705799,-0.07999798,0.033305768,0.010896909,-0.04256461,0.008251309,0.0831161,-0.04499202,-0.004222513,0.15587318,-0.009616952,0.00408217,0.06424769,-0.058284003,0.035886247,0.05719433,0.048349448,-0.07294327,-0.015575675,-0.005962619,0.014189348,-0.0011018829,-0.06909256,-0.0130470935,-0.0700081,-0.016655982,0.06195232,0.0024769385,-0.00092812825,0.015322298,-0.009751173,0.054607604,0.09939607,0.12110404,-0.11339793,0.0030270913,0.055106506,0.02762893,0.027221859,0.023235368,-0.01742847,0.0020621885,0.008439539,0.05612661,0.0068373596,0.035584807,0.036648564,-0.018469747,-0.023266282,-0.08322965,0.022264726,0.068592794,-0.034835994,-0.008048598,-0.045034885,0.048597783,0.032812346,-0.012187576,0.07393077,-0.0040878267,-0.0157232,-0.035065368,-0.09767102,-0.06519158,-0.015687825,-0.022805788,0.021708872,-0.02415871,-0.0433144,0.028062457,0.048730303,-0.083003886,0.00793885,-0.030506575,-0.045249864,0.043718558,0.022752937,0.0067423508,0.0017647401,0.0022446238,-0.023652786,0.029887794,0.048485894,-4.150808e-08,0.07288533,-0.0077776667,0.033618987,-0.013590962,0.007182259,-0.027055832,0.052738108,-0.008513379,0.046493728,0.01869232,0.027980896,0.06876581,0.029361997,-0.012838218,0.08408438,0.06441735,0.017392943,0.007853395,0.024382232,0.024653357,-0.012810671,-0.037488457,-0.08855028,0.10885411,0.015213773,-0.03433286,0.07725459,0.035318185,0.011788063,-0.009619133,-0.034355875,0.0136273615,0.08551669,-0.023566363,-0.07800122,-0.013353469,-0.034454312,-0.048601322,0.0011460136,0.019475488,0.0057358285,-0.047884565,0.0011175523,-0.0042165187,-0.014351743,-0.023769056,0.085459866,-0.05024395,0.0030697442,-0.0055004577,-0.00031042157,-0.008844446,0.019602021,-0.04758592,-0.11480633,0.028596397,-0.009500154,-0.06748998,-0.05933352,-0.02986423,0.04954249,0.05632174,0.1696225,-0.0460694 +1.14.19.22,"This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. The most common substrates are oleoyl groups attached to either the sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. EC 1.14.19.23, acyl-lipid omega-6 desaturase (ferredoxin).",384,1.0,-0.0551271,-0.042940453,-0.10052227,0.03200844,0.006521151,0.027794754,-0.081711896,0.04580247,0.02412392,-0.09600352,0.08622435,-0.047196057,-0.11685015,-0.016408067,0.013702325,-0.014253781,-0.0067220633,-0.0046373797,-0.06676742,-0.015451609,0.10902698,0.023133593,-0.031413216,0.00079618767,-0.05426645,-0.052798726,0.014367682,-0.011653122,0.012181083,-0.048768014,0.05792029,-0.060965933,0.059994176,0.01811006,0.0129941385,0.037510686,0.0055644354,-0.01631084,0.031192647,-0.014875514,0.06331186,-0.025883434,-0.0031340695,-0.027708478,-0.0005470032,-0.11582661,-0.052003816,0.062290765,0.029810088,0.030543217,-0.019134441,-0.09220218,-0.051076178,0.026846062,-0.057011053,0.063422516,-0.046437204,0.0038003835,-0.07449532,0.042052496,0.08433856,0.0013686026,0.0070949853,0.056105398,-0.0021611217,-0.06203059,0.04013365,-0.10289537,0.03584818,-0.014796816,-0.08026903,-0.089894205,-0.02246723,0.0044788183,0.02433499,0.056164227,-0.07686484,-0.054310035,0.07692681,-0.073349714,0.023735989,-0.0097196875,0.013207728,0.10903331,0.053120743,-0.015550841,-0.01562193,-0.018348837,-0.012788675,0.034633443,0.038389638,-0.021811375,-0.048713654,0.042608093,-0.098173924,-0.003527608,0.0105725415,0.035082918,-0.041815232,-0.0065801367,0.03239708,0.039278176,-0.07219975,-0.07449314,-0.03585102,0.037512727,-0.0681803,-0.017081833,-0.02837366,-0.0045326035,0.00013573321,0.035730325,0.06079457,0.02850255,0.007545406,0.055115875,-0.011294201,-0.024099251,0.039328072,-0.035747178,-0.024392035,-0.019193467,0.02947152,0.026517175,-0.032013033,0.00779555,-0.086614735,2.5714033e-33,0.05811542,-0.034565393,0.027678732,-0.026573678,-0.011969869,-0.037969667,-0.09432857,0.025401946,-0.1259425,0.028953966,-0.0181392,-0.038652822,0.042609397,0.08062075,-0.04479051,-0.09066565,0.04685527,0.07164301,0.089524105,-0.0103045385,-0.028406033,0.08295364,0.006470535,-0.06560634,0.041337404,0.06894441,-0.08782645,-0.008539815,0.05555399,0.031450108,-0.041848958,-0.08714118,-0.07006551,0.073915444,0.07261968,0.06763363,-0.019203413,-0.030681964,-0.021609448,0.07438896,0.08202227,-0.009003908,0.017928228,-0.060100812,0.032140527,-0.018775115,-0.08065129,0.07303533,0.073596865,-0.0075681605,-0.00798056,-0.03830985,0.058625124,0.030172296,-0.041439403,0.026065135,-0.033698555,0.011809372,-0.024368338,0.005438524,-0.029625598,0.07552329,-0.08753386,0.025543496,0.055352334,0.023875302,-0.09547391,-0.007763971,-0.04137364,0.09831101,0.028452585,0.030270958,0.09365444,0.06771297,0.044627707,-0.0042022266,-0.038406037,0.07417225,-0.001612171,0.064817205,0.026655942,0.0460288,-0.046000633,-0.09693238,-0.11935547,0.030117052,-0.037961297,-0.03447154,0.04121189,0.05559204,-0.05770845,-0.056065366,-0.010653644,0.013802021,0.01695844,-5.1193543e-33,0.039228957,-0.10332604,0.10151696,-0.03522098,0.014033203,0.062016632,0.018107723,-0.026152655,0.03717118,0.019685052,0.092081815,-0.005185579,0.055021953,-0.031494204,0.03161292,0.07827278,-0.056302983,0.04241665,0.08005835,-0.055367254,0.031407047,0.026337648,0.014315547,0.16275029,0.057303496,-0.0443644,0.014453837,0.04170672,0.00777236,0.042752966,-0.01080107,-0.025365833,-0.02209081,-0.039274346,-0.04655786,0.050600145,-0.109870054,-1.9281802e-05,-0.016652111,-0.014460252,-0.03124059,-0.00071741303,0.032911938,0.030470518,0.09068863,0.035021625,-0.074082986,-0.01087653,-0.039687492,-0.033294804,-0.02224894,0.00504608,-0.009711323,0.022925423,0.035297725,0.13428551,0.019888924,0.017788252,0.020486489,-0.057352815,-0.007346864,-0.044937048,-0.081447326,-0.03706828,0.037120193,0.04291099,-0.015573821,-0.029021787,0.0010165597,-0.008855862,0.093072325,0.047321297,-0.012717734,0.01139026,-0.04164608,0.003930127,-0.041507453,-0.09099593,-0.016442172,0.014927523,0.011885347,0.011714675,0.019805448,-0.062527664,0.031669818,-0.02424941,0.012550338,0.090937324,-0.019539038,0.044523556,-0.049708348,0.010624349,-0.11116239,-0.012443608,0.052744206,-4.421899e-08,0.087104894,-0.07915528,0.029228209,-0.06119886,-0.0554766,-0.03172155,0.058315136,-0.053416684,-0.014903727,-0.103542045,-0.028453588,0.08427416,0.00728124,0.024852673,-0.008733557,0.018086424,-0.037397955,0.0077965655,-0.0115411235,-0.04764683,-0.016581858,0.00096524414,-0.033277757,0.009646806,-0.013967428,-0.034811843,-0.0013314888,0.115075074,-0.012121453,0.042086054,0.033733703,-0.0046246164,-0.014283858,0.023431394,0.022669358,-0.009376726,-0.0716913,-0.03317856,-0.038988657,0.11549883,0.028685082,-0.06760264,0.027881904,0.026568994,0.017637463,0.0113243265,0.03298621,0.071234524,-0.03043464,0.051665705,-0.06738102,-0.000114174516,-0.020418808,-0.023159796,-0.070681974,-0.021165483,-0.0203343,-0.025268225,-0.056654442,0.025957959,-0.025179757,0.03191224,0.19024225,-0.036014985 +1.14.19.23,"This plastidial enzyme is able to insert a cis double bond in monounsaturated fatty acids incorporated into glycerolipids. The enzyme introduces the new bond at a position 3 carbons away from the existing double bond, towards the methyl end of the fatty acid. The native substrates are oleoyl (18:1 Delta9) and (Z)-hexadec-7-enoyl (16:1 Delta7) groups attached to either position of the glycerol backbone in glycerolipids, resulting in the introduction of the second double bond at positions 12 and 10, respectively This prompted the suggestion that this is an omega6 desaturase. However, when acting on palmitoleoyl groups(16:1 Delta9), the enzyme introduces the second double bond at position 12 (omega4), indicating it is an (n+3) desaturase [3]. cf. EC 1.14.19.34, acyl-lipid (9+3)-(E)-desaturase.",384,0.99999994,-0.09312434,-0.0572353,-0.10530661,-0.012512834,0.026361678,-0.00022372123,-0.10123811,0.060970973,0.03312331,-0.10111756,0.06069046,-0.025820466,-0.12646747,0.013169325,0.032703687,-0.032890104,-0.008499261,-0.02153808,-0.05718269,-0.00082889944,0.14996669,0.008835145,-0.0013436022,-0.0042769625,0.010574998,0.021900222,0.007974445,-0.042385537,0.050059907,-0.07644842,0.043447487,-0.0585806,0.019149138,0.00088809466,0.038784947,0.016006524,-0.0052815992,-0.009996528,-0.023603007,-0.00940428,0.10786912,-0.01596448,-0.009996161,-0.022930074,-0.032554917,-0.082330234,-0.056100193,0.045217138,0.011371307,0.024600374,0.010564758,-0.065459944,-0.02613909,-0.011846104,-0.015224375,0.0053439066,-0.06896111,0.00057584577,-0.037396412,0.02683251,0.0966607,-0.008292219,0.020570902,0.020477975,-0.049403317,-0.024494784,0.0376384,-0.08114741,0.0011856726,-0.022799669,-0.06267259,-0.064641975,0.029709006,0.058418974,0.027148508,0.07368163,-0.048760746,-0.003671862,0.052072216,-0.043459523,0.0615806,0.009167642,-0.016272584,0.112778254,0.05288143,0.014941657,-9.5502146e-05,0.01218918,0.025002453,-0.012425301,0.05643545,0.0028779656,-0.05478978,0.038770057,-0.09076857,0.072617516,-0.009523991,0.017609995,-0.039565146,0.02274557,0.05889934,0.032521248,-0.05151191,-0.08519022,-0.062929496,0.01323622,-0.03744712,0.020426014,-0.040810604,-0.003472894,-0.04668094,0.047833145,0.04390069,0.046916284,-0.06300703,0.025310129,-0.024338784,-0.01597728,0.0352999,-0.05850281,0.006392763,-0.049902692,0.03185111,-0.0014207343,-0.02487472,0.0048212283,-0.06254643,3.977112e-33,0.03841824,0.023080906,0.041224264,-0.058904923,-0.0020545674,-0.08096517,-0.07703055,0.041497376,-0.15493554,-0.001509855,-0.012254687,-0.047506224,-0.026889017,0.096024826,-9.864295e-05,-0.02349646,0.079923145,0.07811943,0.03608355,-0.021979252,0.038462285,0.12488239,-0.007860006,-0.043086007,0.0042908196,0.08316773,-0.0511658,-0.01940294,0.08504407,0.023318158,-0.042632576,-0.081795655,-0.07064233,0.060686108,0.083514415,0.03987097,-0.034281038,-0.06059382,0.020222813,0.016889617,0.061934922,-0.038190637,-0.023763921,-0.01126715,0.018445797,-0.0016576137,-0.03847946,0.060103167,0.05230755,-0.01043835,-0.016034806,0.027660519,0.06286428,0.071194194,-0.045582872,0.052820414,0.008504456,0.06769419,-0.03934619,-0.024305493,-0.04602335,0.049066722,-0.0692646,-0.0012532653,0.020558499,0.015831362,-0.10966855,-0.035997756,0.009362193,0.03945518,0.021868156,0.0074397223,0.041670557,0.09156662,0.06669923,-0.041070476,0.033332225,0.118803106,-0.010438345,0.04432617,-0.0020870452,0.04104797,0.0060484097,-0.07362937,-0.1549456,0.014341687,-0.03613986,-0.058826547,0.03053854,0.06409143,-0.019813566,-0.059162937,-0.0019308198,0.03405979,-0.03253945,-5.2881946e-33,0.08213195,-0.050062448,0.11664296,-0.043960374,-0.0023997147,0.021496326,-0.016064452,-0.004373515,0.042784255,-0.05191027,0.09963831,-0.02257068,0.061136782,-0.0028110445,-0.024682391,0.1087678,-0.015968738,0.061203934,0.0075303647,-0.056228764,0.044882167,0.08562944,0.047100812,0.1428253,0.07644261,0.0032740033,0.098532036,0.031854138,-0.0250342,0.015974075,-0.017078994,0.01934652,-0.010710169,-0.019460721,-0.08183244,-0.027742164,-0.064083904,-0.022796214,-0.043004215,0.008990049,-0.036368657,0.019791396,0.02702852,-0.011726266,0.068799816,0.018548245,-0.044431504,-0.01185652,0.011733168,-0.047249593,0.01027854,0.027311318,-0.017626667,0.06844901,0.07446538,0.068055674,-0.0026143813,-0.0069148694,-0.0070327395,-0.06526059,-6.789906e-05,-0.03296757,-0.044904955,-0.03672044,0.07797383,0.0113171805,-0.025052508,-0.058174487,-0.0045554982,-0.010253302,0.02958716,0.021138225,-0.05440808,0.034364007,0.016959699,-0.026571153,-0.06022896,-0.10925314,-0.051525798,-0.035137285,-0.01964269,-0.005888112,-0.02227025,-0.045422494,0.008002067,-0.024202585,0.04417273,0.10573029,0.00029715395,0.07220353,-0.05596236,0.013007737,-0.1020395,0.10115519,0.105795175,-4.998845e-08,0.0733309,-0.04613239,-0.034767367,-0.076528125,-0.081996426,-0.0563929,-0.02287353,-0.08049924,0.018831255,-0.08397561,-0.05405311,0.050829012,0.007630195,0.0020294397,-0.02180494,-0.005881891,-0.027915657,0.0015298501,-1.9586478e-05,-0.04704234,0.022788163,-0.02507513,-0.010953338,0.03256632,0.0006496074,-0.031678308,0.006862393,0.076220036,0.039902158,0.055275965,-0.043597024,0.016351813,0.018962968,0.013133894,0.03563095,0.0654163,-0.04961688,-0.02998313,-0.021250557,0.12221744,0.06620751,-0.03355676,-0.023249805,0.050985474,0.008853147,-0.016908031,-0.01209331,0.08122275,-0.020209685,-0.019935444,-0.030481057,0.035002146,-0.04130628,-0.079157986,-0.11237193,0.007988307,-0.06220725,-0.001891979,-0.06639026,0.01714347,0.027361218,-0.0500888,0.14691694,-0.002203475 +1.14.19.24,"Involved in sex pheromone synthesis in the Lepidoptera (moths). The enzyme from the moth Spodoptera littoralis prefers 13:0 and 14:0 substrates. The product is formed by the stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. cf. EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase.",384,1.0,-0.07991897,0.018583622,-0.06776716,0.011493526,0.057669044,0.08392301,-0.016460687,-0.023117615,-0.023087323,-0.023905553,0.07165738,-0.09438937,-0.08001886,0.013701473,0.020480663,0.06871613,-0.004840981,-0.019780194,-0.027165059,-0.040721256,0.096600816,-0.041933738,0.01565595,-0.029743815,-0.0088663455,-0.059373405,-0.02785397,-0.03591439,-0.013151415,-0.065704845,0.031423405,0.06863484,0.052276634,-0.035754267,-0.024670502,0.0055577685,-0.039054185,-0.0763789,0.13422118,0.01919034,0.044901382,0.01879617,-0.096214086,-0.032336287,-0.11278119,-0.024016878,-0.013773586,0.028431088,-0.027669283,-0.021821141,0.013113999,-0.021521328,-0.016147556,0.13082111,-0.029922457,0.0033396813,0.005249263,-0.047692653,0.020122709,-0.002415331,-0.0058328877,0.053558324,-0.017172119,-0.009181218,-0.008630394,-0.10776676,-0.05401331,-0.057076454,0.05331057,0.009928137,0.018889552,-0.06047059,-0.026783718,-0.0039894064,0.058085643,0.07823846,-0.002414995,-0.09424357,0.0049558003,-0.03879954,-0.057820264,-0.01358859,0.023006918,0.12467605,0.053365253,-0.08586918,0.013098913,0.022963692,-0.050054807,0.015773805,-0.022438483,-0.027402317,-0.030926818,0.0050598164,-0.09180462,0.08620378,0.03135115,-0.03471646,-0.018058807,0.05849172,-0.018899377,-0.0011077208,-0.073174976,-0.06549718,-0.11152507,-0.032522213,0.03320969,0.07546351,-0.035554267,-0.01490836,-0.009733244,-0.054162722,0.0397738,0.051829252,-0.06696661,-0.028173337,-0.032816723,-0.02909055,0.06195008,0.0010723592,0.029990463,0.014278424,0.013515602,0.071910106,-0.0049315514,-0.0058831414,-0.1345704,5.65685e-34,0.06605073,0.027216027,-0.011954226,-0.011818339,-0.033373926,0.032926537,-0.03032444,0.05309673,-0.0055111577,-0.065895066,-0.040726107,-0.01726237,-0.006929521,0.005022866,-0.006113692,-0.028012782,0.10710302,-0.015697433,0.058997814,0.020679383,-0.06254591,0.04391671,-0.03536531,-0.09386608,0.066918984,0.081304304,-0.091217116,0.009956747,-0.0401256,0.0077311536,0.10047223,0.0057317796,-0.01776617,0.14100567,0.065633,0.04902095,-0.0059127845,-0.03327895,-0.051046252,-0.009801254,0.028453872,-0.018284807,-0.03353324,-0.016175553,0.02888398,0.017203819,-0.08197399,0.09715503,0.08060954,0.06447822,-0.020407379,0.038149484,0.10291575,0.019538453,-0.047859542,0.0890474,0.01049839,-0.08909674,0.022550426,-0.05498089,0.02385617,0.034863994,0.029266575,-0.015654197,0.052929107,-0.025648847,-0.031266052,-0.040010165,-0.10205826,0.040046398,-0.05531591,0.008461959,0.025237465,0.029378233,0.03657251,0.050744697,0.0022719363,-0.0029855052,0.039617732,0.028935507,0.052913643,-0.00027747796,-0.00044685818,-0.062559664,-0.033494443,-0.10369511,-0.075019434,-0.03204954,0.061673723,0.08854087,-0.026560988,-0.07813362,-0.020814553,0.0024104284,0.012223698,-1.678818e-33,-0.022646315,-0.056591354,-0.01850465,-0.07808571,-0.05150215,0.08760249,0.03178193,-0.0419978,-0.02418988,0.09186706,0.08138981,-0.01995448,0.009977346,-0.06812619,0.01982713,0.043993242,0.030648185,0.07895227,0.068162635,-0.0400365,-0.047047168,0.13059008,-0.04433432,0.017450098,-0.01802416,-0.010122749,0.13456632,0.09145656,0.076127805,0.0018805338,0.03976019,-0.03396197,-0.014672993,-0.04289053,0.04056261,0.0054613017,-0.055181634,0.0023525138,0.057779144,0.06726376,-0.02588674,-0.01814868,0.010709668,0.008604341,0.069065414,-0.0024369806,-0.03616617,-0.0079435175,0.039842457,-0.03028155,0.0403715,-0.01430591,-0.0621526,-0.09780557,-0.027113117,0.02718338,0.036026396,0.013129172,0.040676456,-0.07110239,-0.00025413788,0.020508442,-0.04606791,0.06037363,-0.098084696,0.039586235,-0.041449454,0.024220938,0.030252192,0.021197557,0.08620993,0.028304823,-0.0076354626,-0.0081671355,-0.10794307,-0.08137475,0.0029326745,-0.04251017,0.058083147,-0.018253021,0.018553952,-0.012886955,0.009077581,-0.02773767,-0.02430731,-0.033855043,-0.04738206,0.05823359,-0.045427293,-0.0005646238,0.0051884097,0.0069540106,-0.009605577,0.08187495,0.041162115,-3.7664613e-08,0.008630056,-0.07331042,-0.00076336635,0.005318019,0.008955692,-0.009110622,-0.001592435,-0.15785883,0.016634513,-0.037570808,-0.06318269,0.02541786,0.07334873,0.003993946,0.07209019,-0.031367496,0.07005813,0.050774388,-0.016934467,0.011382503,-0.018650325,0.034437496,-0.056210447,-0.010064484,-0.0038410285,-0.021932416,0.06766869,0.0029501163,0.00074330263,-0.0005717781,0.056682926,0.09442575,0.04356335,0.026903607,0.027447302,0.022442138,-0.014272325,-0.087963335,-0.009150229,-0.001773065,0.024363903,0.029954651,-0.03641864,-0.0070989337,0.019301547,-0.0016417551,0.06277401,0.017295891,-0.03919462,0.0991312,-0.016273776,0.09922927,-0.033162788,-0.039021246,-0.06634777,-0.043039653,0.029878894,-0.094273716,-0.065044366,-0.004291206,0.079787485,0.0138240745,0.12773354,-0.037076928 +1.14.19.25,"This microsomal enzyme introduces a cis double bond three carbons away from the methyl end of a fatty acid incorporated into a glycerolipid. The distance from the carboxylic acid end of the molecule does not have an effect. The plant enzyme acts on carbon 15 of linoleoyl groups incorporated into both the sn-1 and sn-2 positions of the glycerol backbone of phosphatidylcholine and other phospholipids, converting them into alpha-linolenoyl groups. The enzyme from the fungus Mortierella alpina acts on gamma-linolenoyl and arachidonoyl groups, converting them into stearidonoyl and icosapentaenoyl groups, respectively [3]. cf. EC 1.14.19.35, sn-2 acyl-lipid omega-3 desaturase (ferredoxin).",384,1.0,-0.043212164,-0.051045783,-0.1514729,-0.00082773913,0.06205362,0.04471408,-0.1265304,0.0011231807,0.04261764,-0.060837764,0.11473647,-0.037765715,-0.0926774,-0.029288715,-0.013864863,-0.01852959,-0.048352502,0.03339989,-0.042218685,0.01989589,0.09744708,0.019570954,-0.03850403,0.031765606,0.0025718138,-0.026762448,-0.03173628,-0.055175036,-0.034781408,-0.08684738,0.006479647,-0.056407914,0.047797203,-0.025483962,0.05873348,0.029863315,-0.013374307,-0.014587236,0.019029714,0.04202624,0.043378893,-0.024944428,0.019525755,-0.019322738,-0.07376195,-0.06876887,-0.07434668,0.049445532,0.039039,-0.021492917,-0.056695107,-0.090912126,-0.0332659,-0.008398953,-0.042666186,0.075774744,0.009244097,-0.023630766,-0.0660852,0.062671036,0.07364668,-0.005666283,-0.012833526,0.0068159522,-0.05839093,-0.04361752,-0.027044447,-0.11455371,0.046035673,-0.012634545,-0.08244528,-0.07774089,-0.02542136,0.05194839,-0.009833218,0.06699624,-0.039443254,0.0091367345,0.077395216,-0.05799549,0.019849604,0.012761816,0.010345059,0.06327834,0.012529332,0.016949357,-0.00766907,0.046297986,0.030400144,0.08224879,0.07044855,0.022049988,-0.010307132,0.028540283,-0.045420755,0.055467732,0.10527147,0.023610977,-0.041773934,-0.027098771,0.05495657,-0.010109097,-0.038861997,-0.110619314,-0.059904892,0.059344735,-0.08479851,-0.04572908,0.02440763,0.024766482,-0.037855204,0.026183099,0.026812622,-0.009116065,-0.02398083,0.012167288,0.042913772,-0.0547362,-0.011532422,-0.010430664,0.011547614,-0.019053316,-0.0020838678,-0.0012901245,0.025446737,0.047973525,-0.06759677,5.3191667e-33,0.0706256,0.042813085,-0.049524494,-0.009305915,0.012554887,-0.077654615,-0.07152397,0.052614696,-0.08596603,0.00096375623,-0.060177423,-0.091860384,-0.03214818,0.04611467,-0.03117136,0.017479017,0.02825073,-0.003784049,0.07519093,-0.010701427,0.0036056838,0.04329887,-0.08402197,-0.012956253,0.044801332,0.046782758,-0.064964205,-0.026030647,0.06665387,0.014333953,0.034073196,-0.13204451,-0.10546866,0.056541003,0.082332924,0.047314104,0.023239225,-0.0659712,-0.022013117,0.07583579,0.053586043,0.021302,0.0038520058,-0.03195811,0.05126735,0.0113832345,-0.04267076,0.09296783,0.11578627,0.0070954747,0.027300198,-0.0027271793,0.08105433,0.050875567,-0.051179558,0.057948865,-0.016524807,0.035256032,-0.025793267,-0.001558199,-0.02114554,0.06703973,-0.00354736,-0.01579277,0.0745797,0.051764317,-0.11436162,-0.03413163,0.014062288,0.0077562965,0.0017715058,-0.021510055,0.041980557,0.08102198,0.023201648,0.0017308001,-0.043474905,0.05752421,-0.012182921,0.037627965,-0.009214233,0.047846474,0.030992169,-0.09440006,-0.061026823,0.002383731,-0.018171202,-0.023128962,-0.0061228457,0.014136365,-0.004617094,-0.04756098,0.025106544,0.050661292,-0.021972574,-6.395035e-33,0.07912515,-0.102478,0.102519564,-0.037505403,-0.038789064,0.089296736,-0.09003023,-0.014211473,0.051065363,-0.014093317,0.06301198,-0.00640509,0.08263879,-0.021254156,0.027292328,0.012556468,-0.005120724,0.06838534,0.03374443,-0.016625185,-0.0048849024,0.051092237,-0.0076481267,0.09985554,0.046624467,-0.030529793,0.04603725,0.02576676,-0.008831112,0.040218443,0.06981792,-0.030160826,-0.025229162,-0.06112704,-0.05841388,0.025441851,-0.09199177,0.029918525,-0.01111657,0.04668101,-0.03206087,-0.035945006,0.069732875,-0.019400507,0.061024047,0.014752116,-0.089942634,-0.025305776,-0.024424296,-0.02223942,0.0034273043,0.003415072,0.011458802,0.08368264,0.033522364,0.06523675,0.027563052,0.039870024,0.033704083,-0.085386075,-0.016475182,-0.038395204,-0.08976419,0.005694613,0.05751818,0.071250014,-0.06551476,-0.0627532,-0.0012890195,-0.01029236,0.040734794,0.061682224,0.025381,0.08926192,0.001628505,0.028087368,-0.019596472,-0.100358084,-0.05411353,-0.02857702,0.012752955,0.009813773,0.0427279,-0.081621826,-0.014049975,-0.028231928,0.033364784,0.11411467,-0.026696263,0.04192986,-0.029923253,0.011621141,-0.07247454,0.0013418682,0.10362853,-4.850323e-08,0.055356942,-0.00037366495,0.013898337,-0.11371339,-0.060876634,-0.03274731,0.059301157,-0.041476633,0.055974122,-0.07545583,-0.058550667,0.096677095,0.023184221,0.041851714,0.032795496,-0.027998751,0.0105865775,0.03088709,0.014864865,-0.013364468,-0.037140638,-0.012324268,-0.060603596,-0.012551732,0.009459636,-0.059424452,0.03848059,0.09427538,0.0028573724,0.06338946,-0.008663486,0.059854724,0.010664397,-0.00018864601,-0.02855746,-0.01929009,-0.06344726,-0.054757107,0.00902867,0.10376735,0.07591197,-0.058192633,-0.03938606,0.0135045,-0.01285951,-0.07473369,0.017940037,0.041974675,-0.00065308256,0.021279246,0.007458768,0.011175571,-0.024069825,-0.06283849,-0.074957415,-0.051314946,0.027286187,0.008699863,-0.077859886,0.020471158,-0.06684811,-0.026833955,0.15690988,-0.024178643 +1.14.19.26,"The enzyme, characterized from the endosperm of the plant Thunbergia alata (black-eyed Susan vine), introduces a cis double bond at carbon 6 of several saturated acyl-[acp]s. It is most active with palmitoyl-[acp] (16:0), but can also act on myristoyl-[acp] (14:0) and stearoyl-[acp] (18:0). The position of the double bond is determined by its distance from the carboxyl end of the fatty acid.",384,1.0,-0.07789134,-0.05436893,-0.12810375,0.020918455,-0.004802657,0.049939305,-0.06000061,0.048711553,0.026745005,-0.009165758,0.10639429,-0.028022822,-0.09261867,-0.04469701,-0.032977108,0.04329416,0.008965879,-0.017254895,-0.04473582,-0.0047751595,0.044540156,0.04644005,-0.02263923,-0.017982934,0.0421981,-0.006561573,0.023889882,0.02418869,-0.010930436,-0.07957417,-0.024773572,-0.010992403,-0.011073741,0.0012135432,0.049397025,-0.0012828778,-0.03580449,-0.11201983,0.08500895,-0.03552564,0.07559456,-0.073613055,-0.007041512,0.015077766,0.0029948633,-0.06426962,-0.043711793,0.08990492,0.055803288,-0.04291905,-0.03868154,-0.06712667,-0.042792443,-0.016224753,-0.09293904,0.004387371,0.012399373,0.01821588,-0.01920269,0.093713656,0.11970578,-0.013366441,-0.01503904,0.04541154,-0.0025618796,-0.05263609,-0.02158277,-0.03898697,0.038141582,0.016350513,-0.06914258,-0.042068206,-0.018838117,0.014458272,0.013988639,-0.010491009,-0.008804034,-0.04496351,0.04593787,0.014594812,0.007008297,0.03800374,0.06444097,0.048645325,0.041170556,0.0069667925,0.0098419,0.060707275,-0.020150587,0.01780727,0.07954808,-0.0043614004,-0.056650706,-0.02131358,-0.07864351,0.023622496,0.040787168,-0.055584684,-0.08000667,-0.00662452,0.035627622,0.018182708,-0.07167571,-0.10895223,-0.04937991,0.04020015,-0.06578588,-0.006412815,0.043701645,-0.015169769,-0.023083093,-0.013386215,0.006343347,-0.014233258,-0.021896707,0.05125539,-0.03404431,-0.07035616,0.023758555,-0.04760671,-0.067250185,-0.07335709,-0.001039931,0.07656684,-0.01184157,-0.010959311,-0.08327253,3.1715836e-34,0.042839855,0.025054136,0.03946268,-0.074803695,0.051652756,-0.07496535,-0.11087039,0.030661916,-0.17540444,0.01244997,-0.033481855,-0.115243636,0.003173076,0.0080584325,-0.021985501,0.005588173,-0.008393331,0.059493616,0.073250175,-0.000654807,0.018861955,0.107369795,-0.018078668,0.06414869,0.0056375125,0.08334115,-0.0010770839,0.0041662455,0.032707047,0.018329702,0.0022717481,-0.010639026,-0.086605355,0.04827587,0.067483455,0.019051485,-0.0033275776,-0.025005259,-0.0049462724,0.024349526,0.06715062,0.070476204,0.06386478,-0.018958006,0.0751633,-0.07376176,-0.080217324,0.038575515,0.07758965,0.01499817,-0.02905527,0.020609168,0.055884063,0.0592298,-0.09695716,0.05014442,-0.04547752,0.06241815,-0.009783274,-0.014498105,-0.0032789984,-0.008995928,-0.070470646,-0.011269864,-0.06878824,0.1013513,-0.10410132,-0.041249406,0.06176135,0.09682301,-0.018520113,-0.025541037,0.03284166,0.010289585,0.04742841,-0.00034714854,-0.019712009,0.056189112,0.0004309956,0.09133594,-0.034053415,-0.018504448,0.029472008,-0.078205444,-0.08644793,-0.043498438,-0.041028097,0.016020514,0.075652644,0.034582954,0.049284354,0.0102355825,-0.028969629,0.0052610175,0.024283482,-2.594105e-33,0.13090225,-0.07639062,0.061133757,-0.02791463,-0.011833709,-0.0144840805,-0.07772749,-0.07164713,0.0049576536,-0.012218727,0.15382935,0.035944656,0.025632564,-0.02365396,0.035314966,0.019517478,0.019779423,0.05746556,-0.010055383,-0.03024422,-0.05279342,0.031113753,0.06930231,0.0035438756,0.03200787,-0.040149536,0.008075693,0.0070720944,0.057897512,0.052397724,0.039133023,-0.016279494,-0.052877367,-0.00839779,-0.08332253,-0.009080842,-0.11440625,-0.003162251,0.015486967,0.13816646,0.05933764,-0.009723556,-0.027092095,0.0444474,0.03746815,-0.023878353,-0.07970221,0.009627167,-0.05735319,-0.13511148,0.034496713,0.02744643,0.036942534,0.0341365,0.08895607,0.06681555,0.05185419,-0.012714848,-0.026727157,-0.055531267,0.013392252,-0.020877298,-0.043383516,-0.06658515,0.056560703,0.060916066,-0.043380044,-0.0012516789,0.028538026,-0.018159172,0.049707882,0.09294589,-0.026185673,0.06297471,-0.010861654,-0.03086117,0.0014200456,-0.05356866,-0.025375998,-0.010392245,-0.08941301,-0.004370209,-0.0063023525,-0.059823014,-0.050205544,0.015389494,0.013581308,0.106408745,-0.016623143,0.06135115,-0.07389067,0.061987918,-0.04955793,0.014220226,0.063406184,-4.4074316e-08,-0.020144375,-0.03244344,0.015630411,-0.07388608,-0.025447683,0.0067038494,0.010187308,-0.014473973,0.065687664,-0.039929744,-0.06551765,0.09547463,0.052832693,-0.03127332,0.011293775,-0.049500618,0.079681516,-0.031848922,-0.0010272303,-0.009097551,-0.07558873,-0.012548425,-0.01808617,-0.012733458,-0.06413415,-0.00466696,0.01389523,0.023229875,-0.0024555002,0.099286154,-0.011624501,0.017280646,0.008292861,-0.022554051,0.019047102,0.061629195,-0.0283212,-0.043005925,-0.036302406,0.079245426,0.067163065,-0.07232011,-0.04123642,0.040749595,0.004787154,0.02617258,0.13085853,0.02850446,-0.011554243,-0.03376439,-0.012310016,0.023855986,-0.06124935,-0.014262837,-0.03817007,0.03663282,-0.009810871,-0.018928362,-0.036938626,0.01263528,0.03777509,-0.049493395,0.10269994,-0.03725183 +1.14.19.27,"The enzyme, characterized from the cyanobacterium Nostoc sp. 36, introduces a cis double bond at carbon 9 of palmitoyl groups (16:0) attached to the sn-2 position of glycerolipids.",384,1.0,-0.1153444,-0.043381386,-0.12197609,0.026345078,-0.0010639462,0.046848364,-0.11027592,0.0557012,0.024019685,-0.020123731,0.07764204,-0.039368726,-0.121824,0.031179907,0.018866414,-0.016389096,-0.02116872,0.01359079,0.033105284,0.05710375,0.059025507,0.04657187,0.003096704,0.031054644,0.031627506,0.050211225,-0.015266143,-0.0017869456,-0.0030032913,-0.01983033,0.043253127,-0.05401785,0.03294295,-0.014708291,0.101665735,-0.05282794,0.041959226,-0.020925833,0.045066185,-0.024189817,0.091480754,-0.03254497,0.03503739,0.018896248,0.011369467,-0.024040213,0.0034752518,0.017570475,0.024871577,-0.011116895,0.0076572355,-0.090464845,-0.10761059,-0.017941121,-0.0056911865,0.072387114,-0.09498564,-0.032092083,0.027517678,0.037684295,0.11924498,0.0012657963,-0.011413388,0.058503006,-0.002980883,-0.10178523,0.04281244,-0.06692503,0.06860835,0.044787526,-0.009766646,-0.05821767,-0.03375639,-0.015034299,-0.045690406,0.05270565,-0.00030385316,0.003133153,0.04326862,-0.038241923,0.053016115,0.0027982364,0.062261,0.09295191,-0.019140705,-0.035152614,0.010187626,0.030907527,-0.009400712,0.013486914,0.044756588,-0.0057650646,0.007794756,-0.06773821,-0.09782841,0.009463171,0.066057675,0.041348435,-0.025918847,0.022898857,0.06639779,0.036761347,-0.034792542,-0.121020675,-0.0107756145,0.058334313,-0.03809707,0.0076666093,0.033242065,0.02139977,-0.009305127,0.07837074,-0.020858364,-0.057937216,-0.020991307,-0.003410298,-0.01076707,0.005589779,0.037692703,0.041066226,-0.047418714,-0.09074329,0.017993674,0.017726311,-0.023313625,0.06584148,-0.083080515,7.540397e-35,0.076869555,0.011540984,0.056751817,-0.030051,0.0005558452,-0.06338086,-0.076923214,-0.004575626,-0.16982618,-0.0074810106,-0.08429164,-0.06213623,0.03535412,0.02562846,-0.067575306,0.057435837,-0.04331683,0.008808891,0.10485913,-0.045861606,0.0028092032,0.056813713,0.026457246,0.02086109,0.06477004,0.07181526,-0.033267453,-0.0045157475,0.07664628,0.014952494,-0.030249994,-0.04993943,-0.07499788,0.010213611,0.13407274,0.0349314,0.0062437486,-0.057007413,0.037921563,0.044078294,-0.013092782,0.0035672889,-0.002564844,-0.08375605,0.04409031,0.01179388,-0.06653787,0.04629656,0.056883305,-0.019112227,-0.0046963673,-0.05596154,-0.01567767,0.09664028,-0.083832435,0.017561488,0.038957372,0.07449453,-0.043360077,-0.017271748,0.009902162,0.052707177,-0.07360433,-0.012208765,0.075602956,0.07515074,-0.08913905,-0.0018670915,0.035801843,0.00874603,-0.03375762,-0.017470963,0.061712172,0.022302499,0.021988014,-0.03855546,0.00044756374,0.036259666,0.0266291,0.08195885,-0.03909214,-0.0147515265,0.004014682,-0.071722455,-0.07079009,-0.016366206,-0.06303246,-0.06379066,0.03455199,0.060286153,0.0067239427,-0.07259701,-0.007121306,0.028091677,-0.07686365,-2.6048567e-33,0.07519801,-0.042610962,0.06557254,-0.004073185,-0.026946034,0.032128952,-0.06945042,-0.095837615,0.008573845,-0.008936497,0.10709961,-0.027929192,0.10072245,-0.01602962,-0.012648182,0.004714994,-0.0415497,0.052929513,-0.014237508,-0.01623666,0.0076721446,-0.028394967,0.020390425,0.085296065,0.027312659,-0.03199649,0.018526042,0.031655025,0.03589512,0.026141629,-0.0047161584,-0.0064124316,-0.07551309,-0.083352186,-0.07029607,-0.019039951,-0.07128167,0.023912054,0.038968824,-0.008637594,0.020569533,0.020047354,0.004818287,0.054345235,0.073730186,-0.014898777,-0.0499616,-0.013259165,-0.06404923,-0.067743145,-0.01218543,-0.011896428,-0.056047093,0.0472074,0.028066814,0.07141952,0.04651095,0.010478077,0.028645232,-0.03165311,-0.008814505,-0.074690804,-0.05547344,-0.05661619,0.09276886,0.094181515,-0.032247253,0.011603714,0.027333274,-0.05999989,0.0073892004,-0.0030951623,-0.0035159995,0.022955695,0.0019038355,0.0074730976,-0.014814137,-0.09076845,-0.014898446,-0.02631173,0.031178378,-0.047406156,0.01143404,-0.04438388,0.033530183,0.05099155,0.07573251,0.15360679,0.004056777,0.025948957,-0.06249937,0.065539084,-0.058054578,0.04878836,0.034323454,-3.1257105e-08,0.03912119,-0.07991274,0.022228047,-0.08866129,-0.028886007,0.0709878,0.030261474,0.00652814,0.025312012,-0.04127427,-0.010745115,0.032865085,-0.0077378373,-0.078392014,0.053950008,0.04084717,-0.035270385,-0.0136205265,-0.024425087,-0.00473832,-0.050705075,-0.01624957,-0.035233986,0.030284384,-0.05651054,-0.05964784,0.009229305,0.11186782,-0.03505634,0.061839677,0.005163342,-0.03100647,-0.04968329,0.042029906,-0.022391811,-0.027005637,-0.009484032,-0.0686352,0.03914968,0.0686735,-0.00014990705,0.021641545,-0.10045645,0.046682246,-0.040641885,0.02911672,0.01911944,0.10202517,-0.09464872,0.0021572986,-0.063929476,0.021875637,-0.0849238,-0.043398973,-0.09642117,0.018472474,-0.0027703182,0.0100865085,-0.10379495,0.008974188,0.0050725997,-0.07981263,0.10553686,-0.011680451 +1.14.19.28,"The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 9 of stearoyl groups (18:0) attached to the sn-1 position of glycerolipids. The enzyme is nonspecific with respect to the polar head group of the glycerolipid.",384,1.0,-0.1292015,-0.032735523,-0.11177994,0.02890908,-0.026794005,0.052952453,-0.088672526,0.058654673,0.008328645,-0.03744095,0.088844255,-0.060412984,-0.12010723,0.056461245,-0.00044835612,-0.0015841256,-0.0539273,-0.007054941,0.021714946,0.043838333,0.04843455,0.040700987,-0.035190485,0.07068251,0.032289304,0.034204304,0.01348876,0.029764144,-0.0039173113,0.004110275,0.024069605,-0.10417742,0.028499486,-0.0065437113,0.10052235,0.0035273854,0.035465706,-0.04805493,0.07908129,0.030132959,0.09066846,-0.0055756615,-0.007728225,-0.013497153,0.047976933,-0.009092519,0.007962676,0.034643836,-0.0051161447,-0.0313901,0.01695886,-0.11153038,-0.089404844,-0.015226033,-0.02879446,0.045557916,-0.11291608,-0.034829013,0.013086482,0.007931205,0.1058104,0.007018388,-0.00014083527,0.041129183,-0.018140256,-0.07177668,0.01636024,-0.08589019,0.061475236,0.03668415,-0.019483048,-0.058337826,-0.09188454,-0.006532896,-0.03549534,0.04846041,0.005033411,-0.010928891,0.020716498,-0.040276952,0.06469327,-0.023396574,0.05052522,0.10141186,-0.0058728983,-0.01696128,0.009585362,0.04023022,-0.011017028,0.011503493,0.029060092,0.022579333,0.02710655,-0.06520757,-0.10179862,0.014207765,0.054312613,0.043015227,-0.012800035,0.032107715,0.054620814,0.018668758,-0.044220563,-0.087774836,-0.016241645,0.0427106,-0.011849034,0.014902644,0.031806137,-0.009621186,-0.010842901,0.040141053,0.023982681,-0.0447544,-0.021820217,0.031082066,-0.031583294,0.022591557,0.031498287,0.06436503,-0.018466517,-0.07105784,0.023302957,0.052603275,-0.018186819,0.078989685,-0.11809853,7.840289e-34,0.06401748,0.0345008,0.063183814,-0.039767046,0.003471816,-0.045202564,-0.07230776,0.02274385,-0.1645198,-0.035725225,-0.088246435,-0.031335782,0.04513359,0.022769684,-0.08561414,0.048622385,-0.017928952,0.042521093,0.10014745,-0.013546737,-0.015582389,0.04205961,0.000787114,-0.009800196,0.05342095,0.04119022,-0.06001723,0.0072601684,0.050665498,0.0014324449,-0.037091635,-0.08768376,-0.08732785,0.003355085,0.15090606,0.009915412,0.011907764,-0.047903325,0.022256989,0.049903933,-0.006282555,-0.0013480682,-0.01217164,-0.056749273,0.07333333,0.018986724,-0.081524886,0.027759109,0.05105887,-0.017771894,0.0051750615,-0.03177532,-0.0024722323,0.04765634,-0.08304237,0.02772682,0.040144186,0.10501538,-0.02651557,-0.0055654896,0.008849203,0.10359746,-0.0856411,-0.025025023,0.053785317,0.06757997,-0.059764773,-0.0039814953,0.026030123,0.023481352,-0.06460352,-0.013673522,0.032440063,0.0073698172,0.036636993,-0.03958675,-0.01119057,0.04130091,0.029095508,0.07560941,-0.088925846,-0.030530423,0.01613079,-0.09564111,-0.07954695,-0.02003481,-0.012892586,-0.060352575,0.03761674,0.064590625,0.023905993,-0.05908746,-0.035449028,0.011647962,-0.041142743,-3.4490834e-33,0.054056287,-0.08397595,0.02318521,-0.0425087,-0.05456328,0.051462736,-0.048965074,-0.09910181,0.036117878,0.004746584,0.12614493,-0.021280177,0.07296772,-0.0007923946,-0.003347958,0.036119998,-0.048563216,0.072862744,-0.009253772,-0.022318684,0.002747934,0.008166254,0.027503915,0.09651196,0.008821449,-0.011793078,-0.0050334465,0.0618082,0.064169094,0.030780341,-0.016018568,-0.031023437,-0.062226936,-0.10116695,-0.062271122,0.03471204,-0.065866016,0.0040511545,0.060615126,-0.006469557,0.024943775,-0.016549751,-0.00020448607,0.08309818,0.056050085,0.030532682,-0.041479792,-0.011423038,-0.06076319,-0.05165791,-0.0397917,0.0013761261,-0.03344493,0.05281195,0.021976834,0.055152208,0.040118936,0.051246017,0.0040780455,-0.023778427,0.0028371243,-0.08995061,-0.0533236,-0.030012337,0.07989665,0.07016792,-0.029932508,-0.039263766,0.043727256,-0.07290285,0.05212349,0.013247845,-0.021339659,0.01609756,-0.0301723,0.01910972,-0.010787741,-0.105312414,-0.03813811,-0.017990712,0.032155808,-0.018511405,0.005071187,-0.024252526,0.01254007,-0.005415227,0.046607643,0.14689192,-0.018054279,0.01739773,-0.009950344,0.05050439,-0.049410038,0.030773483,0.03588898,-3.361743e-08,0.0454538,-0.078961186,0.055517133,-0.0994647,-0.033603266,0.041472904,0.04206179,-0.034111198,0.012508527,-0.050867394,-0.0259407,0.024677856,-0.0044048196,-0.06138305,0.07247103,0.03303492,-0.056396805,0.00027503064,-0.017487748,-0.008717262,-0.047268588,-0.023178173,-0.051268537,-0.00046467548,-0.041675035,-0.08208188,0.03930626,0.08730919,-0.040332213,0.048267115,0.027314281,-0.032277934,-0.045805667,0.05561062,-0.0060035423,-0.008543914,-0.042260416,-0.032623257,1.3937773e-05,0.059537996,0.00068005075,0.0026116816,-0.106167495,0.03857255,0.0009939417,0.05274102,0.0403846,0.07462925,-0.05946442,-0.0027208,-0.046646845,0.0046624276,-0.059767395,-0.03221428,-0.1150576,0.021624394,0.015576813,-0.01119353,-0.11137841,0.025536625,-0.009967492,-0.030702617,0.14824396,-0.033405293 +1.14.19.29,"The enzymes from higher plants convert sphinganine, 4E-sphing-4-enine and phytosphinganine into E/Z-mixtures of Delta8-desaturated products displaying different proportions of geometrical isomers depending on plant species. The nature of the actual desaturase substrate has not yet been studied experimentally. The enzymes contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase [1]. The homologous enzymes from some yeasts and diatoms, EC 1.14.19.18, sphingolipid 8-(E)-desaturase, act on sphing-4-enine ceramides and produce only the trans isomer.",384,1.0,-0.057614,-0.004853712,-0.06128415,-0.07189749,0.030255433,0.030493816,-0.012981576,0.043879777,0.003196164,-0.011983523,0.08153349,-0.100573435,-0.08598194,0.04252615,0.049004775,-0.0004255067,-0.04680518,0.07398464,-0.06141523,-0.058764312,0.11896411,0.00086771674,-0.064869024,0.050123364,0.037329804,-0.07929626,-0.020496132,-0.07436728,-0.0046623833,-0.12584043,0.019519519,-0.0011223216,0.008878808,-0.02804441,0.024000512,0.02728417,-0.009278509,-0.045086086,0.07547141,-0.033805594,0.038475975,0.04327533,-0.04096777,-0.027367644,-0.076321706,-0.017068692,-0.007769907,0.04969505,0.021266099,-0.08587078,3.412064e-05,0.014243972,-0.018790668,-0.010905925,-0.07810601,-0.029372647,0.035760626,0.046095543,-0.011321598,0.019090192,0.06406995,-0.010377015,-0.0028955778,0.0009410891,-0.055391908,-0.022327974,-0.0021381283,-0.068917654,0.04858597,-0.020433523,-0.06984375,-0.083028495,-0.06194516,0.057127677,-0.023427906,0.10685405,-0.009408464,0.0039916434,-0.06379419,-0.049418226,0.034735937,0.0057071964,0.059016816,0.03705237,0.038737547,0.047196724,-0.073474616,0.042757876,0.04112581,-0.00103533,0.06470223,0.018614337,-0.007438488,0.07637569,-0.04562552,0.11354803,-0.004679651,0.057559688,0.021032609,-0.0046432144,0.03679313,0.033670373,-0.048541978,-0.058635823,-0.014160236,0.01786976,0.061129954,0.013075942,-0.05273948,-0.0076952237,0.0064197863,-0.014240141,0.04842415,0.04095003,-0.060805794,0.0017856769,0.010453662,-0.023936253,-0.022140441,-0.0537381,0.008415977,0.05317867,0.009185518,0.008340999,-0.0015627302,0.06488093,-0.062794276,3.2304767e-33,0.04163637,0.020848602,0.038358822,-0.025940448,-0.0880737,-0.048808247,-0.048744474,0.019448517,-0.039656185,0.0013767324,-0.12011624,-0.027190827,-0.004065637,0.034761716,-0.035971433,0.011599801,0.06291082,0.040954538,0.053025626,0.029434808,-0.05288204,0.0536493,-0.13701867,-0.06414752,0.030111672,0.045490585,-0.07381768,-0.0047654384,-0.012620554,-0.036924206,0.018464731,-0.053316392,-0.053722966,0.06875121,0.09693465,0.0034560866,0.03717699,0.020519791,-0.030542932,-0.012306701,0.029006485,0.03043091,-0.001909155,0.014450881,0.032249346,0.06669039,-0.11614945,0.013737522,0.03433921,0.062023055,-0.00023695097,0.027607862,0.088666216,0.009433156,-0.014394464,-0.0057308725,0.043435913,-0.0041477554,0.07428339,0.016291209,-0.06959941,0.11188642,-0.054137878,-0.015972095,0.06287832,-0.011512354,-0.0688626,-0.04653193,-0.07216565,0.04789745,-0.11113587,-0.032904744,0.059322976,0.0283334,0.064640485,-0.04281549,-0.08473218,-0.0044201924,0.01322488,0.08239674,0.054638136,-0.019935967,-0.050308585,-0.10437779,-0.024635442,-0.0048498306,-0.034249138,0.004729352,0.040658664,0.020858623,0.06687529,-0.04558252,-0.0127143925,0.057778753,0.031918917,-4.2479104e-33,0.03508244,0.019431567,0.02677979,-0.042889602,-0.04492657,0.069239795,-0.013030316,-0.01829453,0.020383531,0.028004749,0.057910636,0.015773676,0.010287769,-0.02345562,-0.054975837,0.02041409,-0.00076077675,0.11192982,0.040984605,-0.03579732,-0.0076802564,0.15744731,-0.043801263,0.08218486,0.08152447,-0.022027643,0.08551402,0.101413645,0.0084153395,-0.038187668,0.023170473,-0.050852228,-0.0027359473,0.0009926544,-0.054237593,-0.0737442,-0.047074966,0.04583385,0.017984992,-0.028562112,-0.086913474,0.026471015,0.021605445,0.054926053,0.09070605,0.080735154,-0.06683384,0.023514196,-0.042250108,0.059465446,0.023001082,0.045267664,0.0015266964,-0.028512767,0.050343342,-0.0022508146,-0.010100482,0.06585043,-0.046360496,-0.005527689,0.007478134,-0.07494589,0.0065207924,0.0030813944,0.0016780633,0.041300103,-0.020746503,0.061378937,-0.032171786,-0.02115133,0.012732429,-0.0030813687,-0.043544717,0.025971249,-0.056084152,-0.023590112,-0.0652818,-0.10822955,-0.02639209,-0.0043860697,-0.042510908,0.023276107,0.069951355,-0.057527456,0.061188396,-0.018354189,-0.07452542,0.02463917,0.06458953,0.034429707,0.021868976,-0.07317695,0.0030552915,0.08593702,0.13656007,-4.1827537e-08,0.053244982,0.0007770423,-0.0033017974,-0.07945437,-0.096586294,-0.06519538,0.0036035771,-0.039509643,0.061244268,-0.060000937,-0.06205579,0.087424465,-0.03776521,0.106856026,0.08720803,0.004973479,0.040878296,-0.010032616,0.012822632,0.05198532,0.03126293,-0.030234845,-0.10317495,0.020873029,0.05352203,-0.051177338,0.05974237,0.07649175,0.074644096,-0.0012964762,0.040808458,0.0059472644,0.03380278,0.035361644,0.023384355,-0.04151088,-0.07147224,-0.064537674,-0.0124441795,0.03657428,-0.033070084,-0.13614638,0.006027883,0.0037089372,-0.044357207,-0.013279314,0.047576513,0.029352376,0.042233814,0.022955723,0.015768537,-0.039802022,-0.009861888,-0.10002155,-0.102219366,-0.0029840001,0.0044565345,0.033941448,-0.020693228,-0.050734524,0.012075589,-0.00051461975,0.12164387,-0.04691876 +1.14.19.30,"The enzyme, which has been characterized from multiple organisms including the moss Physcomitrella patens, the marine microalga Rebecca salina, and the filamentous fungus Mortierella alpina, introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Delta8 double bond. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.",384,1.0,-0.08757647,-0.044760745,-0.10734662,-0.01959677,-0.022383647,-0.01652567,-0.08733572,0.0049294564,-0.0013743091,-0.049695026,0.07018708,-0.091421604,-0.11705008,0.026253274,0.006448269,-0.009621549,-0.042984664,0.010937844,-0.064126074,-0.00022299298,0.13256551,0.025840597,-0.03599357,0.019427544,0.007076191,-0.039823562,-0.013258037,-0.024496656,-0.032158308,-0.11389682,0.0070452765,-0.017097345,0.006416279,-0.024691528,0.0918901,0.057727996,-0.024131458,-0.07997438,0.027622163,0.026972799,0.0482971,-0.051380582,0.008856314,0.017198691,-0.060060345,-0.11208638,-0.03266241,0.046457514,0.060407065,-0.054560702,-0.09100969,-0.08807571,-0.07888715,0.0006775145,-0.012459131,0.037642818,0.016730614,-0.020837652,-0.041582007,-0.02880869,0.0909727,0.04162795,0.009033826,0.016050968,-0.031593323,-0.061398298,0.013558811,-0.115306035,0.034902126,-0.017554468,-0.06609062,-0.07993501,-0.02515248,0.029424591,0.003121148,0.041914105,-0.062571354,-0.03867299,0.025433013,-0.0068425955,0.0143401725,0.002334948,0.019806067,0.09404392,0.054132607,-0.009470901,0.0127793765,0.017854223,-0.034735393,0.010954205,0.045654707,0.0034809562,-0.023330104,-0.011535403,-0.11710223,0.054517526,0.017227467,0.046929214,-0.04459389,-0.024156917,0.05157354,0.02347539,-0.054773286,-0.09603529,-0.051627267,-0.008220147,-0.0032100587,0.057551604,0.015249224,-0.052683994,-0.02719669,0.049856722,0.01272129,0.027113304,-0.0038045722,0.03745505,0.027350552,-0.07186023,0.054546207,-0.064001605,-0.021122137,-0.044590957,0.02917651,-0.009066629,0.005875729,0.022640157,-0.13904022,2.7294593e-33,0.07562662,0.026480304,0.012458441,-0.04721434,-0.034301,-0.06407591,-0.08778326,-0.006133939,-0.107147954,0.00030404446,-0.04365538,-0.015062483,0.004436668,0.08010748,-0.041821722,0.002950454,0.045073636,0.01800523,0.09474181,0.045636225,0.04765019,0.123168014,-0.026427044,-0.044843446,0.07129517,0.07799573,-0.028421672,0.014559484,0.03181299,0.045613434,0.008051344,-0.12221995,-0.11157823,0.0382526,0.16024461,0.021000162,0.023917386,-0.014018501,-0.06787576,0.04373043,0.044323754,0.012851403,0.021325348,-0.030802708,0.07884647,-0.0016750648,-0.0747823,0.07192772,0.053982303,0.025460733,0.041022997,0.016661758,0.049350318,0.023562403,-0.07561916,0.07951254,0.020483296,0.012211945,-0.06398301,0.02167374,-0.027654106,0.058228917,-0.06834226,0.0062285475,0.07122676,0.06657557,-0.04943453,-0.0015130576,0.014341616,0.0775884,-0.050441284,-0.022311391,0.09395305,0.014977005,-0.013539378,-0.010511583,-0.057919506,0.011920995,-0.019670239,0.04652999,0.038744915,-0.04229384,0.02091754,-0.06540018,-0.10818893,0.014726486,0.02348584,-0.008083982,0.032493677,0.04146051,0.031225095,-0.08792524,0.014404158,-0.028370915,0.009457717,-4.2680304e-33,0.095717706,-0.08929164,0.058489125,-0.037808016,-0.020297328,0.028321182,-0.018724155,-0.045092233,0.031891007,0.006979751,0.09526683,0.025450055,0.045789987,-0.03809306,-0.0066036335,0.03732824,-0.005136689,0.053848654,0.03980183,-0.029100325,-0.012458483,0.05868846,0.06542006,0.09294615,0.09572224,-0.010391501,0.042099927,0.06122702,-0.022207236,-0.05258105,0.015043894,0.015653562,-0.007448167,-0.10429713,-0.10381111,-0.006102057,-0.099022724,-0.004723108,0.04413761,0.015198912,-0.006129205,-0.0027150537,0.04672098,0.07035654,0.05169873,0.050511196,-0.07313586,-0.0022500886,0.006095232,-0.011580872,0.013689506,0.017121164,0.029400926,0.0028185954,0.06372414,0.058660425,0.017391339,0.09087806,0.04444148,0.022384524,-0.020974347,-0.041400548,-0.028052276,0.0020918387,0.058635533,0.0630468,-0.048372947,-0.045172475,-0.01881985,0.03557643,0.057511132,0.07280599,-0.048910912,0.055516466,-0.07297288,0.010854033,-0.062242694,-0.06360348,-0.02314479,0.03409898,0.0062938933,-0.021513876,-0.0057752687,-0.086402915,0.039266903,-0.08238302,0.0019541304,0.09312775,-0.015532494,0.024884908,-0.029680904,-0.0025156755,-0.063432306,-0.009109121,0.07007485,-4.0768573e-08,0.050450895,0.003915367,-0.038647354,-0.048890974,-0.038516536,-0.041362923,0.010545506,-0.05416933,0.04388947,-0.030917626,-0.026701711,0.08188554,0.008630929,0.035146434,0.026294142,0.011072726,0.022167128,-0.026121452,-0.0059898184,-0.0053357626,0.008116318,-0.019738203,-0.119347095,0.058784608,-0.0020482927,-0.029786037,0.06429814,0.05378354,0.059745625,0.07979403,-0.002739877,0.025487015,0.016733255,-0.014283034,0.00607666,-0.0055797845,-0.050732344,-0.030367527,-0.021109838,0.055606764,0.043693855,-0.04715047,-0.07014688,0.022304261,-0.012196089,0.022886097,0.02216365,0.029384363,-0.020882837,0.022048455,0.026168557,-0.016370893,-0.018664207,-0.01858645,-0.13060455,0.048685145,0.029832738,-0.006995168,-0.069309354,0.012139453,0.019477835,-0.010878647,0.19006224,-0.036914755 +1.14.19.31,"The enzymes from several algae introduce a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Delta7 double bond. The enzyme from the fresh water alga Chlamydomonas reinhardtii acts on the 16 carbon fatty acid (7Z,10Z,13Z)-hexadeca-7,10,13-trienoate [5]. The enzyme contains an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome.",384,0.99999994,-0.092657946,-0.0077870437,-0.10406538,-0.016457267,-0.07100977,0.04604753,-0.0651275,-0.034130514,-0.021950122,-0.019128464,0.05481451,-0.13703106,-0.07907043,0.027906979,0.060335945,-0.00921297,-0.036711685,-0.04807548,-0.04373403,-0.03265997,0.103534274,0.017051222,-0.041745007,-0.0043628835,0.029983241,-0.0076550175,-0.010748553,-0.010775136,0.009387081,-0.099003635,0.054164216,-0.021109316,-0.014965373,-0.03724749,0.071426235,0.03167504,-0.035199843,-0.13009626,0.032372285,0.0363059,0.07189086,-0.0012258934,0.023903541,-0.0013307893,-0.040046398,-0.0808237,0.002261961,0.08083311,0.07105228,-0.06221228,-0.04552516,-0.070588045,-0.030118758,0.02365553,0.020600846,0.013208829,0.012778731,-0.010314768,-0.03217151,0.019764887,0.12170249,-0.009373123,0.02665869,0.03457664,-0.06692642,-0.0843203,-0.027558869,-0.1130791,0.025118075,-0.04027894,-0.078550614,-0.06369597,-0.02709365,0.017007597,-0.0048460667,0.042420473,-0.024762578,-0.10413624,-0.03672475,-0.033829994,0.029675398,-0.02297574,0.05152455,0.10010961,0.04827002,-0.039418306,0.026622158,0.0071123275,-0.007928857,0.0168283,0.073280245,-0.008729992,0.0050520524,0.007006664,-0.14725316,0.06294422,0.03538148,0.05489598,-0.021315135,-0.003983082,0.041142832,0.0114887245,-0.05684636,-0.10754212,-0.03265913,0.0042886767,0.01594813,0.11034621,-0.018001232,-0.045388322,-0.013699452,-0.016718872,0.02152295,0.0680712,-0.011139891,0.05892022,0.04247285,-0.10042115,0.00837487,-0.05076444,-0.07753468,-0.097243346,0.08477366,0.0010260727,0.013894226,0.018724168,-0.14583686,8.114501e-34,0.0499567,-0.024058187,0.016936073,-0.07118393,-0.019723939,-0.07532474,-0.077850014,-0.03366338,-0.073662795,-0.04356341,-0.048906494,0.017316593,0.042883098,0.064284205,-0.05826503,0.011240045,0.038404997,-0.00810611,0.05100652,0.04044435,0.028249541,0.08983278,-0.04715616,-0.05606094,0.04272882,0.07237334,-0.016028408,-0.00031893837,0.053556003,0.015966045,-0.0150156645,-0.06699152,-0.09135764,0.054116175,0.14640054,0.02864822,-0.008499076,0.008649905,-0.065404095,0.01831912,0.073062256,-0.008425807,0.029848855,-0.03135631,0.08828167,0.026437527,-0.08623345,0.0596815,0.050855685,0.034938656,0.050026998,0.0547041,0.049498063,0.01103797,-0.11571929,0.06367958,0.019096324,0.029369144,-0.004086708,0.00831676,-0.081648305,0.025486207,-0.096606836,0.01615809,0.040286776,0.029923107,0.033593163,-0.024031622,-0.003240198,0.042501982,-0.08168665,0.0035043994,0.10601389,-0.003816981,0.03176621,-0.0020539619,-0.065991685,-0.032828312,-0.012264514,0.071971014,0.04600459,-0.021985302,0.07063804,-0.06613743,-0.07941975,-0.015592246,-0.011879298,-0.001181117,0.065034695,0.042292345,0.048588697,-0.034962438,0.009334419,0.00077301066,0.05076102,-2.5780988e-33,0.10970005,-0.07413188,0.04551887,-0.0790533,0.0044241496,0.02722203,-0.0024902376,-0.041393653,0.042147398,-0.03436862,0.15048248,0.011195822,0.026377818,0.008833569,0.026606852,-0.017380696,-0.019622538,0.076039754,-0.005382545,-0.05008978,0.0041169655,0.030146793,0.025123205,0.12976551,0.07224848,-0.0064412975,0.050587207,0.0043378123,0.02123355,-0.014107314,-0.0329546,-0.02006955,-0.012803545,-0.044232674,-0.068355866,-0.029777573,-0.09976082,-0.016584368,0.026348017,0.057116944,0.023520311,-0.016826015,0.027710434,0.0034712232,0.04769045,0.056696493,-0.053874806,-0.010940597,-0.035981003,-0.0047674137,0.033677787,0.0028285836,0.025760852,0.015172823,0.08741772,0.0753564,0.023358598,0.05967908,0.062779196,0.006824445,-0.013235879,-0.06767163,0.021828467,-0.02899798,-0.022665512,0.034373473,-0.035153806,-0.05802519,-0.034875873,0.0038540158,0.03647633,0.057596575,-0.08924148,0.06816366,-0.052552078,-0.050094802,-0.061170217,-0.083474554,-0.050935954,-0.009719798,0.0012932165,-0.0004517408,-0.0011050922,-0.055304267,0.065035716,-0.03586164,-0.001848828,0.057894126,-0.008469278,0.02868028,-0.009963945,-0.0036327785,-0.057198502,0.0333567,0.055480488,-3.8607503e-08,-0.0063569644,0.016831608,0.0022192972,0.008986801,-0.0076772985,0.005426656,0.0005594006,-0.038763672,0.07750893,-0.059437964,0.026139218,0.053619754,0.02714069,0.04940208,-0.015839517,0.024131771,0.02779316,-0.10187201,0.022517841,-0.011794128,-0.0027971545,-0.057501674,-0.06415218,0.064613424,-0.016056675,-0.018424628,0.030296408,0.0942953,0.03848592,0.024718989,0.0030554307,-0.012435254,0.031799216,-0.004409044,0.020436192,-0.00028724392,0.02676641,-0.059212536,0.0013671141,0.065634556,0.058698956,-0.034776405,-0.029527085,-0.011126874,-0.008083158,0.04211016,0.019746494,0.033055495,-0.005583864,0.022610016,0.029797517,-0.02147926,-0.005781593,-0.041598506,-0.07744116,0.042692162,-0.005764222,-0.017746875,-0.09824298,0.034758493,0.08393539,-0.019000689,0.15968683,-0.013193307 +1.14.19.32,"The enzyme, found in the moth Ostrinia furnacalis (Asian corn borer), produces a mixture of (E)- and (Z)- isomers. The products are subsequently truncated by partial beta-oxidation to a blend of 12(E/Z)-tetradec-12-enoyl-CoA, which are converted to the species-specific sex pheromones (E)- and (Z)-tetradec-12-enoyl acetates.",384,0.99999994,-0.064406104,0.020443408,-0.048441384,0.07207522,0.0936571,0.025763677,-0.011158872,-0.08121418,0.018039666,0.013606806,0.11627552,-0.087230965,-0.063093096,-0.020218983,-0.020478936,0.026122143,-0.06552088,0.004037188,-0.019748593,-0.032186214,0.05963617,0.022687618,0.042032305,-0.020588372,0.024838945,-0.051749744,-0.024369383,0.012986355,0.022577511,-0.104637675,0.013162342,0.043848023,0.056677,-0.030503511,-0.034631774,-0.0060936357,0.008344719,-0.089470595,0.043717884,-0.013019972,0.045994584,0.011892012,-0.0792896,-0.0026481305,-0.111589864,-0.071432844,-0.025393514,-0.040044773,-0.030119186,-0.040870205,0.01575106,-0.11878904,-0.054470204,0.0867553,-0.026707977,-0.005217285,0.015783781,-0.026894538,-0.005210261,0.06599753,0.068983465,0.022953331,-0.05106168,0.018008549,0.013352045,-0.056917004,0.007938251,-0.033746056,-0.005566335,-0.05736224,-0.03951804,-0.06842058,-0.0065594264,0.013901308,-0.029294908,0.09312202,0.0129578505,-0.06733734,0.050380696,0.038077086,-0.075753674,0.0018874741,0.008961257,0.07533034,0.08601187,-0.027784593,-0.05522342,0.007023509,0.018177152,0.06402754,0.026765602,-0.0136484,-0.032543935,-0.032021623,-0.058823343,0.035970975,0.04532577,0.059160233,0.03410796,0.029800577,-0.022713834,0.011019022,-0.07553699,-0.1316414,-0.12647809,0.0051521356,0.06939527,0.020085666,0.041513514,0.038054787,-0.10867015,-0.062985234,0.015881134,-0.0053689866,-0.06786621,-0.028724039,-0.035112537,-0.06337538,0.057965145,0.029371163,0.03291718,0.030728407,0.007644559,0.07780487,0.08073683,-0.0014055286,-0.07852557,-8.431032e-34,0.017581971,0.08300951,-0.02101321,0.03791718,-0.0159723,0.029790172,-0.025290249,0.028079392,-0.06783281,-0.048057713,-0.10403191,0.04192347,-0.014641909,0.024071421,0.043534935,0.011073515,0.056739178,-0.036699038,0.08621515,0.01838598,-0.02704265,0.032575835,-0.07781524,-0.072101876,0.006911556,0.06373551,-0.07083804,-0.009123628,-0.01455774,-0.0009473711,0.14916582,-0.047332183,-0.064623944,0.06420972,0.08738366,0.028674489,0.025156694,0.01515933,-0.065658085,-0.0067020124,0.06384748,0.020451771,-0.010294967,0.028093422,0.03487943,-0.0316644,-0.054431487,0.07257344,0.099093765,0.007032288,0.035114758,0.0046693794,0.08093737,-0.002939287,-0.068025716,0.1336006,-0.0006849048,-0.09842961,0.011074569,0.030168375,-0.01879,0.060148466,0.07764255,-0.043048363,0.03269442,0.0016955996,-0.038858764,-0.021612108,-0.09031695,0.07869606,-0.029726934,-0.0088594835,0.055232543,0.02108789,0.026642822,0.037120223,-0.042006947,0.012922955,0.023653807,-0.04640747,0.025221389,-0.0680053,0.009532965,-0.009706738,-0.05877151,-0.06661807,-0.061514042,0.032478444,0.09324718,0.14399709,0.04174505,-0.0727304,-0.008687696,-0.024675848,-0.00016991347,-9.768214e-34,0.030803291,-0.029411417,-0.0061341436,-0.12549491,-0.048978947,0.07927442,0.012725902,-0.028254325,-0.013047847,0.053846348,0.09433613,-0.023929138,0.063597254,-0.07478009,0.0005907626,0.036325157,0.001627056,0.11986581,0.09163765,-0.050131578,-0.067355536,0.06079019,-0.013215006,-0.010882926,0.0075924993,0.033039086,0.11361076,0.08706587,0.049721163,-0.013438447,0.0303055,-0.114624314,-0.004018547,-0.042338986,-0.0078849085,0.04305663,-0.05440143,-0.010348838,0.023982406,0.024387002,-0.030720456,0.0031358858,-0.003944458,0.0063864286,0.04876626,-0.023572478,-0.028712746,-0.033637427,0.009202031,-0.040068705,0.1129871,0.04422092,-0.09784975,-0.021566926,0.0019669859,0.04394745,0.00908474,-0.045972332,-0.035394695,-0.033394545,-0.00033135677,-0.009436855,0.006997927,0.008744731,-0.012760481,-0.02286339,-0.011500296,0.023783604,-0.0032764706,0.034872934,0.07597656,0.018490704,-0.000808351,-0.011752415,-0.06934819,-0.04977275,0.012713812,-0.043306876,-0.004602188,-0.032824904,0.001029232,-0.0461563,0.0041052783,-0.034953613,-0.04717279,-0.048216574,-0.009402817,0.12164981,0.014101138,-0.019607037,-0.03735306,0.024410417,-0.015488211,0.09144188,0.08474614,-4.3186912e-08,-0.01626282,-0.101671085,-0.016166585,-0.021385128,-0.019817326,0.0020328905,-0.037168045,-0.12961885,0.007624392,-0.019606968,0.00836868,0.09396153,0.034781802,0.02527495,0.051376276,-0.05564298,0.03360866,0.07615913,0.013845488,0.026947558,-0.07160425,0.04863934,-0.048435085,-0.03412426,0.00971947,-0.025854427,0.03867916,0.056639496,0.01661489,0.028260874,0.008632399,0.069938414,0.018455395,-0.015953723,-0.041140903,0.029117318,-0.043917775,-0.10791505,-0.054714106,0.024020026,0.005228037,-0.031707577,-0.028918212,-0.012678524,0.009220064,-0.0025032274,0.0762089,-0.0033253042,0.021692246,0.062207233,-0.0009801298,0.033333316,-0.05567828,-0.04096894,-0.047074225,-0.05137439,0.024447877,-0.04426427,-0.03497273,-0.026027145,0.058825802,-0.042179465,0.12545526,-0.017202245 +1.14.19.33,"The enzyme, characterized from the plants Impatiens balsamina, Momordica charantia (bitter gourd) and Vernicia fordii (tung tree), converts a single cis double bond at carbon 12 to two conjugated trans bonds at positions 11 and 13. The enzyme from Vernicia fordii can also act as a 12(E) desaturase when acting on the monounsaturated fatty acids oleate and palmitoleate. cf. EC 1.14.19.16, linoleoyl-lipid Delta12 conjugase (11E,13Z-forming).",384,0.99999994,-0.070531435,-0.017161952,-0.08266897,-0.013008242,-0.018939445,0.02614132,-0.07783968,0.06587488,0.022251662,-0.04195616,0.07600924,-0.0555591,-0.13248868,-0.04239861,0.018544232,0.0052113533,-0.027134668,0.047252562,-0.073248394,-0.017117701,0.1482723,0.019355604,-0.006858157,0.021817677,0.03336122,-0.026422836,0.009691544,-0.053445674,0.04161209,-0.06626137,0.013738498,-0.050457623,-0.029652167,0.009377721,0.00026489882,-0.029667297,-0.010754258,-0.038271893,0.07986389,-0.03797727,0.07562788,-0.010403275,0.032106355,-0.03645614,0.01145059,-0.057626687,-0.053104367,0.072169326,0.046937823,-0.052067045,-0.0031577952,-0.03967246,-0.077902205,0.0006469877,-0.01642736,0.022352614,-0.030811017,0.023762058,-0.032348994,0.119642556,0.10368348,-0.0012725089,0.044061594,0.0069053606,-0.060435478,-0.074934885,-0.0019340785,0.0041430094,0.05766942,-0.059206784,-0.04969778,-0.058114316,-0.05876302,0.0010063547,0.0007869875,0.069919035,-0.023966491,0.014348905,0.04278094,-0.033772282,-0.012643332,-0.018403314,0.021753676,0.06176983,0.04806672,-0.033222508,-0.019237783,-0.0061169607,0.03174628,0.009729991,0.05402974,-0.00052365515,-0.02911564,0.02673206,-0.12366477,0.07193952,0.040371157,-0.0057576275,-0.0048418855,0.018231908,0.015769301,0.040972292,-0.044572722,-0.12433349,-0.16096744,0.006995622,-0.01877518,-0.006199562,-0.031037161,-0.031310856,-0.01448156,-0.012814812,0.053350303,0.058074687,-0.026995279,0.02060862,-0.0007469314,-0.09936887,0.05176658,-0.06300458,-0.075402394,-0.048418023,0.042883746,0.084665366,-0.028550422,-0.01296967,-0.030482383,4.3421068e-33,0.07401396,0.019346684,0.00918999,-0.0011722336,-0.045243878,-0.031087467,-0.11300847,0.011295308,-0.17340784,-0.013543191,-0.04214897,-0.10625171,0.02065055,0.02063113,-0.025315642,0.011509501,0.062280696,0.023220288,0.11335498,-0.048168432,-0.0136519065,0.13999149,-0.043225173,-0.071165256,0.023754057,0.07252326,-0.038775012,-0.0030687319,0.052613813,0.022233872,0.026879622,-0.08995515,-0.055644993,0.0720245,0.039269365,0.034818005,-0.021386992,-0.020310495,-0.0048191966,-0.043662608,0.094684415,0.043176584,0.0153402435,-0.030506363,0.050043393,-0.0075387903,-0.027334562,0.039616305,0.099681094,0.028431391,-0.030347005,0.021310633,0.07831961,0.0442548,-0.07224189,0.054566957,0.06420546,0.040424198,0.033750914,0.030231902,-0.069091655,0.03294231,-0.10205842,-0.011445185,0.048886653,0.021268615,-0.0995042,-0.015864562,-0.019850675,0.040623777,-0.022245178,-0.037049446,-0.012914144,-0.0073847016,0.010891582,-0.023203056,-0.026794111,0.06798511,-0.017764673,0.101536416,-0.029970124,0.042759907,-0.006174637,-0.08548122,-0.07167463,-0.0074279476,-0.079757884,-0.05020829,0.0748649,0.06817427,0.04617311,-0.048099283,-0.051325828,0.05102106,0.0541663,-5.0672446e-33,0.052795283,-0.045032736,0.04572342,0.004957294,0.023666682,0.018870361,-0.019715516,-0.062012717,0.04698219,-0.03475718,0.10740243,-0.027172754,0.039924737,-0.047961686,-0.010972666,0.0011617223,0.035427622,0.11215524,0.007178724,-0.041559417,-0.0072727595,0.07134453,0.0072481707,0.042283446,0.01846501,-0.00011873028,0.05043543,0.05982409,-0.011198433,0.025171697,0.039808054,-0.037172854,-0.03228597,0.021774253,-0.097252995,-0.049770672,-0.06963246,0.029472778,3.3939952e-05,0.0354736,-0.016647516,0.022369957,-0.009171132,0.025533954,0.023750471,0.034418557,-0.058413953,-0.0034538782,-0.012956076,-0.01258364,0.08836734,-0.012111696,0.03521714,0.021776577,0.09485123,-0.0024739671,0.061426807,0.031761233,-0.017427607,-0.03154919,-0.0011192838,-0.045946784,-0.043991413,-0.113239035,0.020986153,0.058456413,-0.05195283,-0.009739766,-0.0015837336,-0.020388236,0.021914294,0.043308202,-0.060512148,0.03681527,-0.06037108,-0.074260615,-0.021704972,-0.08810855,-0.029369941,-0.026885044,-0.043800063,-0.054985087,0.012219685,-0.091749914,0.015769877,-0.016633358,-0.017102381,0.11863073,0.04543121,0.088155754,-0.065830104,0.023105083,-0.045992386,0.04580528,0.11928747,-4.614563e-08,-0.009065094,-0.057205826,-0.0028073383,-0.0026478043,-0.0847192,-0.028747473,0.018474156,-0.047151472,0.0102340365,-0.037191313,-0.019719351,0.07203548,0.022763314,-0.005609465,0.0046595284,-0.0069935475,0.045539785,-0.013135923,-0.030636204,0.0070482153,-0.00010844522,-0.035786718,-0.05194833,0.015647786,-0.008273376,-0.078336924,-0.008776244,0.07852282,0.057220154,0.047274407,-0.004180581,0.031149756,0.04034038,-0.0133306,-0.008338761,0.027637944,0.013565627,-0.02881426,-0.03346323,0.10709414,0.09448961,0.012467087,-0.062369384,0.0094033275,-0.0203127,0.022668812,0.0051014526,0.087215014,0.014944264,0.0004829999,0.00089271745,0.03163035,-0.011078232,-0.027406562,-0.11174977,0.0020949165,-0.004446453,0.0277768,-0.02777924,0.036670826,0.076712996,-0.04345608,0.16831762,-0.010380817 +1.14.19.34,"The enzymes from the plants Dimorphotheca sinuata (African daisy) and Vernicia fordii (tung oil tree) insert a trans double bond in position C-12 of oleate and palmitoleate incorporated into glycerolipids. The enzyme introduces the new double bond at a position three carbons away from an existing double bond at position 9, towards the methyl end of the fatty acid. The enzyme from tung oil tree also possesses the activity of EC 1.14.19.33, Delta12 acyl-lipid conjugase.",384,1.0,-0.073875375,-0.021012392,-0.10719928,0.05874428,0.014339359,0.05292011,-0.09720581,0.016240992,0.017463997,-0.060187887,0.0832853,-0.065797545,-0.16435608,-0.06217198,0.0054324507,0.015398041,-0.03701758,0.0019696716,-0.05349753,-0.03700987,0.12215464,0.02734017,0.021865003,-0.007836282,-0.005783464,0.002641152,-0.018285299,-0.091066375,0.010655377,-0.060736172,-0.021158813,-0.052817833,0.036866575,0.016575499,-0.004747993,0.008494754,0.0012232297,-0.015902124,0.044817716,0.0037068014,0.075222366,-0.07216357,0.032549575,-0.0652041,-0.019874278,-0.04677018,-0.035284124,0.036281906,0.04863943,-0.009333199,-0.04415157,-0.08668576,-0.072001584,-0.026059108,-0.04465658,-0.034132417,-0.0035595552,0.03895009,-0.0154162105,0.0906265,0.1391464,0.036684584,0.041660134,0.05672705,-0.101383016,-0.12099142,-0.0044274535,0.0011227982,0.030939497,-0.05068507,-0.03941944,-0.07022709,-0.07799925,-0.010812043,-0.020730548,0.059139896,0.014632895,0.0034790356,0.097245686,-0.03809411,0.007680232,-0.0052979407,0.00040114092,0.072450176,0.042179104,0.014574501,-0.032225948,-0.015118754,0.0034942487,-0.0007302483,0.070088506,-0.040045206,-0.071072325,0.056793433,-0.10076611,0.06906279,0.052916743,0.0034055493,-0.032329846,0.00016812573,-0.04835113,0.02255972,-0.07104347,-0.13532774,-0.12749562,0.0309665,-0.04652533,-0.01998503,0.03924083,-0.0006875921,0.0016590949,0.020025017,0.03268069,0.026880478,-0.052439146,0.0038871332,-0.03734087,-0.1047782,0.004523012,-0.034711294,-0.014578158,-0.065268494,0.047753204,0.02546404,0.0028094621,-0.032939624,-0.015018445,3.9799407e-33,0.09334138,0.017366193,-0.02499614,-0.031814344,0.011144228,-0.061008446,-0.087834135,-0.0028311328,-0.17196728,0.030983604,-0.047567163,-0.07431581,0.002303352,0.036658593,0.00019450438,0.023034822,0.060102478,0.05298753,0.10354964,-0.044610754,0.016570525,0.08149601,-0.026165336,-0.056602094,0.03262588,0.068042144,-0.016493266,-0.051324908,0.048450146,0.02516869,0.06679253,-0.11330097,-0.048145976,0.030099953,0.035796747,0.035259005,-0.03333601,-0.048614524,-0.02513727,-0.010472429,0.04227426,0.054226875,0.029612478,-0.02189152,0.03171987,0.022030298,-0.06272986,0.073627196,0.09716889,0.052583218,-0.036123123,-0.009980192,0.09960519,0.06888741,-0.034955636,0.061300583,0.014600634,0.03777466,0.014683825,0.020810451,-0.032481275,0.04481191,-0.08677684,-0.036899406,0.0410033,0.016310638,-0.10371192,0.009230832,-0.0029056547,0.034197036,0.007859052,-0.039784502,0.017345166,-0.009523433,0.011522743,-0.03127902,0.031254154,0.052709863,-0.030295657,0.070544355,0.013856413,0.016829703,0.053717166,-0.0705153,-0.08789903,-0.007389618,-0.090728566,0.0050881472,0.057590496,0.03530616,0.0028141227,0.0022436893,-0.028885389,0.046591215,0.0051710308,-4.832223e-33,0.07164797,-0.025525538,0.08627347,-0.03998398,-0.010574041,0.045687027,-0.048504647,-0.029477743,0.009854166,-0.06684859,0.08851085,-0.0065298704,0.049497843,-0.01436107,0.007064091,0.009417948,-0.0008628366,0.08215821,-0.010242469,-0.030284707,-0.011976042,0.053793445,-0.0021136752,0.07479155,-0.0021104808,-0.028254332,0.030952524,0.014993919,-0.04005624,0.03690348,0.022903513,-0.008238241,-0.06755972,-0.02923701,-0.07537493,-0.036507167,-0.062010217,-0.025949163,0.048276037,0.056499343,0.050576553,0.03765046,-0.018423691,-0.014318804,0.07160621,0.008143185,-0.08499801,0.0013283255,-0.00951837,-0.058828972,0.033575576,-0.0074282307,0.009329572,0.044382263,0.07437792,0.072782256,0.042576063,0.032443468,0.027670208,-0.093632035,-0.03390906,-0.044271067,0.020033915,-0.025412409,0.0116922865,0.122140385,-0.006499289,0.013158521,0.011152133,-0.0010221525,0.017975666,0.06951996,-0.048072897,0.04002534,-0.014598709,-0.05561558,-0.037011757,-0.11166817,-0.06356209,-0.014144896,0.023601199,-0.002044795,0.02892488,-0.11777872,0.03840375,-0.010794705,-0.023484537,0.113760285,0.054404262,0.052911464,-0.09589258,0.0135133,-0.047588926,0.044852126,0.07128956,-4.314769e-08,-0.03691331,-0.0034826698,0.05023332,-0.025859386,-0.08567304,-0.014765586,0.042408355,0.033455677,0.011179927,-0.026893714,-0.03992798,0.13638446,0.0032682621,-0.031232923,0.054239158,-0.00941708,0.004275903,-0.013576458,0.0052049686,0.003459308,0.032122523,0.003168836,0.018805498,0.020353185,-0.010672229,-0.042226765,0.05369129,0.046063177,-0.0047585615,0.026260363,-0.01922603,0.05737002,0.03377888,0.05754051,0.023975058,-0.026717696,-0.03692157,0.014431723,-0.0868932,0.08422205,0.03474973,-0.026788596,-0.034954753,0.0013822417,0.0037084904,-0.006181038,0.026472747,0.09039207,0.01699229,-0.036468733,0.029017124,0.0067761787,-0.009873728,-0.06547065,-0.087022476,-0.05726742,0.007150471,0.009178161,-0.0353532,0.030174188,0.037525278,-0.047121882,0.17371802,-0.008327856 +1.14.19.35,"This plastidial enzyme desaturates 16:2 fatty acids attached to the sn-2 position of glycerolipids to 16:3 fatty acids, and converts18:2 to 18:3 in both the sn-1 and sn-2 positions. It acts on all 16:2- or 18:2-containing chloroplast membrane lipids, including phosphatidylglycerol, monogalactosyldiacylglycerol, digalactosyldiaclyglycerol, and sulfoquinovosyldiacylglycerol. The enzyme introduces a cis double bond at a location 3 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. cf. EC 1.14.19.25, acyl-lipid omega-3 desaturase (cytochrome b5) and EC 1.14.19.36, sn-1 acyl-lipid omega-3 desaturase (ferredoxin).",384,1.0,-0.0910002,-0.06261336,-0.12313523,-0.0375639,0.022489073,0.039752256,-0.09811137,0.048530027,0.04919088,-0.11070547,0.06305487,-0.030047346,-0.07402899,0.026675403,0.031990472,-0.022345321,-0.014335051,0.024753746,-0.058201678,-0.04504436,0.14577602,-0.0043153223,-0.02920284,0.03693373,-0.030710325,-0.014475821,-0.016269926,-0.025735268,-0.05538879,-0.0495222,0.07227261,-0.0989127,0.042320788,-0.02073273,0.04626364,-0.006930546,-0.017324068,0.007304159,0.014424021,0.007827456,0.058563665,-0.00013226496,-0.03527002,-0.02180343,0.045117296,-0.0757263,-0.0516191,0.05531264,0.019900538,0.0038019265,-0.0059530074,-0.07607543,-0.024680808,0.0032757458,-0.014392405,0.061033525,-0.09253972,0.015756728,-0.03532092,-0.0018464107,0.050798304,-0.036684632,0.026069952,0.015917487,-0.018587144,-0.062868804,0.034328792,-0.118850164,0.010143261,0.00061757315,-0.08315471,-0.06302091,-0.016421856,0.019480053,-0.016571354,0.059848126,-0.027403915,0.0053123794,0.03374048,-0.07138522,0.07138605,0.0065153786,0.02214396,0.13095267,-0.0038964713,-0.034277953,-0.029730054,-0.0025029816,-8.72372e-05,0.047582373,0.076326616,-0.056055147,0.005065076,0.05612924,-0.052642077,0.037949856,-0.000649406,0.028669795,0.0044840337,-0.00860693,0.046391074,0.02964546,-0.061901797,-0.11349906,-0.0009050085,0.052832372,-0.053927377,0.0029320256,-0.004912594,0.015615075,0.012125559,0.042809986,0.08865731,0.032707643,0.019451069,0.06665303,-0.017422298,-0.000673188,0.049079098,-0.012938904,-0.022436665,-0.065641865,0.018145261,-0.004023999,0.00076025334,0.06562344,-0.09534357,5.7457014e-33,0.01718964,0.00074605155,0.008348212,0.00039740308,-0.01153762,-0.07295402,-0.067816444,0.08706273,-0.11965107,0.0020367203,-0.064709224,-0.039599217,-0.0040902607,0.025417272,-0.052324455,-0.007896473,0.0947363,0.026992267,0.04479449,-0.032093093,0.0005528378,0.060509246,-0.009705225,-0.06915525,0.04769021,0.03324582,-0.06204827,0.0019949863,0.07068416,0.002975409,-0.048777886,-0.092921995,-0.05828531,0.07185363,0.1215278,0.041137435,-0.02189912,-0.02560155,0.0051790955,0.046256837,0.046654064,-0.0024779371,-0.010311148,-0.017940445,0.07414672,0.00082784984,-0.08003835,0.0831575,0.069822006,0.019533265,0.015131036,0.025011482,0.059291832,0.046975274,-0.025333105,0.016386244,0.026259407,0.040940702,-0.011545237,-0.02079791,-0.040155947,0.07516705,-0.07669624,-0.04720757,0.08703171,0.05365621,-0.12842551,-0.047294516,-0.027463855,0.027450442,0.00070706545,0.042705346,0.052031193,0.077625744,0.06970872,-0.036841404,0.031258784,0.077547766,0.011110338,0.062758386,-0.017830389,0.08491836,0.022502296,-0.06486664,-0.118794635,-0.013196369,-0.0031068225,-0.05676384,0.029919496,0.005110128,-0.022913516,-0.09591813,-0.005981744,0.06611582,0.009204381,-6.6789745e-33,0.03583704,-0.06531888,0.09769825,-0.053313047,0.0012373441,0.067359686,-0.011182779,-0.002164652,0.08076523,0.010636288,0.117064714,-0.03469833,0.04033018,-0.016478036,0.038465742,0.07550961,-0.03964815,0.040550165,-0.044376105,-0.035743672,0.015379545,0.08980364,-2.9158015e-05,0.15867078,0.033467278,-0.007703967,0.065975815,0.04651258,0.0076724347,0.030584425,0.007992514,-0.048602406,-0.052390363,-0.044580918,-0.05341159,-0.005514418,-0.09634287,0.03215283,-0.0348483,0.014870412,-0.01576912,-0.012416674,0.056400232,0.03056568,0.07193806,0.06859185,-0.067544006,-0.02164578,-0.010030494,-0.041470792,-0.0057906695,-0.0041153,-0.019777998,0.103423044,0.09331575,0.08312593,0.0073069874,0.044936027,0.003908184,-0.09332668,-0.030120088,-0.08215682,-0.04964449,-0.036632985,0.048407797,0.052656807,-0.069902144,-0.0722376,0.045012,-0.020019015,0.021453934,0.020302003,-0.028575202,0.008271789,-0.045293532,-0.024225999,-0.056467228,-0.10746197,-0.02815565,-0.020398175,0.021827955,0.026413515,0.018594433,-0.061100747,0.03356644,-0.025471255,0.04378899,0.06505007,-0.02079108,0.030392295,-0.006504789,0.012396484,-0.085409455,0.013747534,0.06394064,-4.9138535e-08,0.070497036,-0.046070985,0.00694444,-0.06781312,-0.06494086,-0.030702759,0.049381923,-0.023541786,0.012846662,-0.09730313,-0.039493997,0.056010384,0.0048360364,-0.018864121,0.015832292,-0.0054512676,0.008950087,0.027709533,0.024524203,-0.035472564,0.008476451,-0.018286048,-0.060015112,0.03334415,0.01579908,-0.07418508,-0.0025355069,0.051064916,0.02645623,0.03950356,0.019697355,-0.03179389,0.03901931,0.03252864,0.012291639,-0.016660603,-0.08468192,-0.04561815,-0.00019001488,0.11874017,0.05007143,-0.05407536,-0.022034846,0.06414693,0.017710738,-0.06924094,0.03029635,0.063335255,-0.04707704,0.0061388067,-0.044719394,-0.0036849238,-0.020557107,-0.07308366,-0.08030359,-0.0438928,-0.0029898214,-0.03749371,-0.08427174,0.047647186,-0.010105662,-0.015892282,0.13949776,-0.010696978 +1.14.19.36,"The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 15 of linoleoyl and gamma-linolenoyl groups attached to the sn-1 position of glycerolipids. The enzyme is an omega desaturase, and determines the location of the double bond by counting three carbons from the methyl end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid. cf. EC 1.14.19.35, sn-2 acyl-lipid omega-3 desaturase (ferredoxin).",384,1.0,-0.1376351,-0.019019332,-0.124570586,0.025628196,0.023893943,0.041565083,-0.086260766,0.06661371,0.018382266,-0.08323778,0.06677333,-0.0694873,-0.10239228,0.0324342,-0.009439189,-0.020764912,-0.03292696,-0.0046979054,-0.0200649,0.03285255,0.09134506,0.02672289,-0.039597332,0.053416,0.039348718,0.03070436,-0.00020422548,0.008650312,0.0127530275,-0.03600598,0.022295099,-0.09527784,0.04552013,0.03431654,0.077890925,-0.0045597176,0.010868343,-0.03866172,0.066277646,0.016999427,0.09143135,0.023883699,-0.0020711403,-0.010017396,0.016659228,-0.036201175,-0.0655722,0.0520479,0.02442146,-0.0059861206,-0.007384172,-0.08432295,-0.06572794,0.00036986638,-0.02365609,0.047777124,-0.05945351,-0.05871652,-0.022768337,0.031704407,0.12671126,-0.021201698,-0.0011486871,0.046509743,0.0029674948,-0.06587006,0.0009012319,-0.09974507,0.038766332,-0.013132706,-0.048929732,-0.07278044,-0.05730439,0.033999126,-0.03888525,0.05197156,-0.030397976,-0.001653529,0.023101188,-0.04441716,0.029512076,-0.012869693,0.031954397,0.13611108,0.035924528,-0.009001494,-0.028025564,0.014008515,-0.020959452,0.0341968,0.031665467,0.021532713,-0.0014736088,0.017275238,-0.08995399,0.055476263,0.054561462,0.04047207,-0.013654352,0.043588065,0.025046036,0.03379449,-0.024285125,-0.11000136,-0.018453805,0.014766526,-0.037741106,-0.0031426807,0.027930282,-0.008883187,-0.028703684,0.018453058,0.043688383,0.037863113,0.007739959,0.038687054,0.017692242,0.005405905,0.036386542,-0.013085787,0.0040386575,-0.09281713,0.03202465,0.017332295,-0.0284643,0.048333246,-0.104101926,1.9002393e-33,0.09027188,-0.010599416,0.037647106,-0.01367047,-0.0053385664,-0.03744394,-0.08521607,0.030682271,-0.11745601,0.017523183,-0.08445276,-0.016242877,0.036411032,0.020455113,-0.08655614,-0.0061318437,0.009998806,0.046701092,0.08121883,0.0044416655,0.019109204,0.048412643,0.012178192,-0.034675606,0.046526875,0.047043305,-0.098870814,0.001627844,0.0525497,0.021120764,-0.032185238,-0.1183472,-0.08283284,0.045674775,0.13146985,0.004940157,-0.009381553,-0.04657993,0.010906104,0.070539035,0.035250887,-0.02923853,0.0024245135,-0.079770796,0.05124637,0.024578847,-0.09116297,0.062361866,0.055235203,0.018117623,0.019981787,-0.016773188,0.010936347,0.030735161,-0.05393007,0.04126227,0.03933081,0.082755506,-0.037311003,0.012595888,-0.014793337,0.09307455,-0.06648332,-0.026873287,0.07935781,0.03540083,-0.101727195,-0.013608847,0.01577176,0.03812987,-0.026528187,0.014846992,0.090333305,0.03632154,0.050749876,-0.056802236,-0.046044737,0.082027,0.026604297,0.0745112,-0.058668293,0.02847621,-0.0013859892,-0.086577624,-0.1021663,-0.010315897,-0.019973017,-0.06441316,0.04143154,0.034528576,-0.02139538,-0.03588944,-0.040833384,-0.0062960093,-0.0104508,-3.8885805e-33,0.056941576,-0.09713987,0.06483176,-0.027768647,-0.023134664,0.04511439,-0.07323123,-0.068405345,0.06852907,0.014872047,0.15020815,-0.011494138,0.06503223,-0.0057551637,0.020118302,0.095640875,-0.04572874,0.052357305,-0.014460257,-0.052998446,0.023281049,0.009346798,0.02636572,0.104565315,0.041003972,-0.024394603,0.02134083,0.031364996,0.020827446,0.038561326,-0.030529315,-0.00800258,-0.046849385,-0.10684091,-0.06218178,0.009852216,-0.09544391,0.030975498,0.024771605,-0.029485948,-0.004095663,0.009801284,0.02852481,0.060384575,0.08513967,0.061514918,-0.043619968,-0.035268795,-0.0068218983,-0.012213178,-0.0031838,-0.00833042,0.0037320654,0.06641073,0.016442211,0.07898038,0.027333582,0.06509087,-0.011910084,-0.015323624,0.013032418,-0.093738474,-0.06449078,-0.018206162,0.032846477,0.060297124,-0.079906985,-0.031153107,0.024027633,-0.0336843,0.051821016,0.011488319,-0.01560115,0.017477527,-0.05318685,-0.013729605,-0.021402448,-0.109212264,-0.057988357,-0.031577285,-0.004599994,0.018851215,-0.021650052,-0.056180958,-0.015061674,-0.011435801,0.037453208,0.11627438,-0.020063482,0.010459905,-0.06032114,0.04855127,-0.106260985,0.02252419,0.059853688,-4.2193555e-08,0.039487217,-0.0791279,0.032893807,-0.07116992,-0.028792521,0.035315048,0.026303252,-0.056560054,0.042046525,-0.086442254,-0.0016151443,0.08270717,-0.013519579,-0.035067722,0.027678993,0.022911688,-0.025801832,0.024551054,0.0010831294,-0.00978908,0.0042178296,-0.013906204,-0.025244536,0.014684975,-0.0123659475,-0.067916706,0.01331182,0.09355338,0.0026060415,0.053827953,0.017615847,0.0034588005,-0.009099427,0.019309614,-0.015674341,-0.012540109,-0.07078386,-0.05669438,0.0023011013,0.0845646,0.0001538279,0.009435764,-0.083088815,0.030385744,-0.0028239666,0.02669348,0.02754346,0.07968796,-0.04150928,-0.000694297,-0.05843372,-0.005904459,-0.030269414,-0.04857773,-0.11631318,0.054725662,-0.0016038022,-0.020474503,-0.116035864,0.016948037,-0.050907508,-0.021889947,0.17157386,-0.014179785 +1.14.99.51,"Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine.",384,1.0,0.027479379,-0.009541292,-0.10310555,0.038725466,0.12596957,0.039115384,-0.062007908,0.015878802,0.01080334,-0.06834027,0.036648884,-0.0646304,-0.060638897,0.0074375467,-0.017176587,0.025054652,-0.052834462,0.009939879,-0.03283785,-0.059609227,0.050357305,0.014563141,0.00905049,-0.038977794,-0.0044430792,-0.04143743,0.035927344,-0.033209596,-0.031361714,-0.12207222,-0.008330372,-0.073193096,0.04526133,-0.04495708,0.015781779,0.08300617,-0.034877807,-0.012443237,0.020190775,0.01888417,-0.032002248,-0.067723855,-0.01793445,-0.025667995,-0.047573667,-0.07123808,0.006906636,-0.013010427,0.04861554,0.031160459,-0.035159595,-0.01791386,-0.014783937,0.00022211045,0.031859882,0.038076278,-0.0570945,-0.00805507,-0.048841856,0.024092752,0.08795314,-0.0016485254,-0.0069870157,0.005948994,0.0163909,-0.078177124,0.07681953,-0.07834577,-0.022125462,-0.063033044,-0.045993306,-0.067947336,0.010045663,0.038002465,0.041961487,0.025613945,0.01137273,-0.037269514,0.08353066,0.026434446,-0.025544655,0.006113603,0.029352162,0.03432195,0.06603671,0.03907806,-0.052239686,0.032515764,-0.04420868,0.07708311,0.07554369,-0.006599538,-0.0067774807,0.0038281968,0.05560873,0.078587115,0.014578725,0.06286317,0.042101324,-0.03395607,-0.019808643,0.08246572,-0.045408875,-0.031684827,-0.018040732,0.0058099274,-0.0047080764,0.08007429,0.018336572,-0.028669486,0.08759154,-0.02047148,0.03919853,-0.046169356,0.03326607,0.08397333,0.076414645,-0.049274907,-0.008714694,0.025505695,0.060346518,0.013745324,0.0029421286,0.06891272,-0.015226284,0.004307006,-0.102636315,2.0865572e-33,0.10316865,0.10679841,-0.05535756,0.015582777,-0.042501472,0.08215591,-0.061126404,0.044207733,-0.037392378,-0.0763976,-0.09978271,-0.057148714,0.044093624,0.036117923,-0.04339596,-0.054303885,0.0520869,-0.06228001,0.08900799,-0.023823671,0.022380184,0.011205947,-0.020582125,0.006608444,0.026708111,0.08703696,0.011561733,0.007192369,0.031989947,0.0045305933,-0.0072254706,-0.094141625,-0.09853744,0.074134834,0.09192733,-0.004386135,0.0043415157,0.019384684,-0.028204098,0.004415523,0.030959409,0.096871205,0.0032356314,-0.07737298,0.030694062,-0.09168071,-0.022774892,0.0965309,0.049490474,0.043591376,0.026064169,-0.011839292,0.091058806,-0.034673173,-0.03141968,0.011047223,-0.02824517,-0.008296935,0.055874016,0.079045676,-0.012954144,0.057668768,0.0072436603,0.084800154,0.05655913,-0.00024014334,-0.06172381,-0.040825274,-0.044924226,0.037567776,-0.045335267,0.0005443541,0.059106734,-0.011314294,0.033084515,-0.07964178,-0.14219563,-0.018228982,0.025634706,0.015661748,0.005848774,-0.03452148,-0.011257644,-0.03049814,-0.059365638,-0.010567608,-0.027577424,-0.0367001,0.02501936,0.013828586,-0.013393999,-0.07040568,-0.053831197,-0.0050914325,0.064368434,-4.0915245e-33,0.067642234,-0.10937831,0.04119543,-0.085340634,-0.039816063,0.071444646,0.021898886,-0.07556213,0.0084772315,0.031071384,0.07003567,-0.022830954,0.03536134,-0.0976606,-0.017012915,-0.019157467,-0.06152815,0.090636685,0.050615434,0.023069752,-0.057839263,0.09569135,-0.003209158,0.060258873,0.10915585,0.006737375,-0.042275093,0.02662614,0.03249576,0.0433436,-0.06191035,-0.01708541,-0.036324874,-0.08474128,-0.051081065,0.064607516,-0.077963576,0.00090607454,0.04366097,0.009409259,0.021049997,0.01904709,-0.0085246805,0.091181725,0.042232625,0.09060173,-0.055927876,0.10062917,0.0026470637,-0.066536695,0.011102037,-0.03101409,-0.04244918,0.021698745,0.040050276,0.015264466,0.024963347,0.0015018496,-0.028047567,0.0040014656,-0.0458705,-0.03279974,-0.007182809,-0.009592602,0.055573687,0.010515039,-0.09216757,0.057938103,0.03828065,0.029143402,0.08645002,0.0055045295,0.039677948,0.022645576,-0.059063047,-0.061981145,-0.0535769,-0.025368487,0.027395101,0.013228965,0.016443828,-0.02023304,0.04607197,-0.06583422,0.0045708786,-0.09442261,0.039248597,0.070432626,-0.06280552,-0.0041644853,-0.028398018,-0.014860454,-0.101721704,0.07907356,0.018475927,-4.1955577e-08,0.028425274,-0.05547587,0.029363373,-0.13746543,-0.016278591,-0.004546785,0.04491777,0.0027601584,0.027107634,-0.011190542,-0.064554475,0.114161566,0.03471057,-0.0028368572,0.04341791,-0.0011208437,0.049031775,0.11303772,-0.016143242,0.002314312,-0.046803568,-0.054189976,-0.11721409,-0.004115617,0.013915821,-0.053309802,0.0050154193,0.007366715,0.07370982,-0.037901927,-0.0024264771,-0.010040897,0.028644051,-0.03513749,-0.10730505,0.023751052,-0.05905678,-0.07708699,-0.011326531,-0.02869914,-0.008613218,0.0021981706,-0.06256527,-0.014053167,-0.057282735,-0.06182017,-0.00067044783,-0.0043977825,-0.03452568,-0.014297877,0.027310316,-0.081029326,0.0064335023,-0.058986124,-0.05052029,0.037268408,0.024423674,-0.046367686,0.04402609,-0.06259534,0.002730014,-0.0026181561,0.16906269,-0.038827866 +1.14.99.52,"Requires Fe2+ for activity. The enzyme participates in ovothiol biosynthesis. It also has some activity as EC 1.13.11.20, cysteine dioxygenase, and can perform the reaction of EC 1.14.99.50, gamma-glutamyl hercynylcysteine sulfoxide synthase, albeit with low activity [4].",384,0.99999994,-0.03976428,-0.049800623,-0.09221359,0.06926741,0.07057673,0.022192353,-0.056827076,0.05718934,0.05155306,-0.05331257,0.008204451,-0.027194379,-0.0353219,0.0016512971,-0.08807475,0.04906102,-0.031268995,-0.0014261662,-0.03817965,-0.057200633,0.0137073975,-0.0102163125,0.00979659,-0.011341966,-0.022804955,0.004554714,0.034382038,0.013028963,-0.062709406,-0.082407504,-0.016213499,-0.07661213,0.074362166,-0.031145439,0.0029302652,0.09147206,-0.024418283,-0.06756328,-0.036301557,-0.028737327,-0.018495295,-0.07332961,-0.023548726,-0.049394965,-0.0014996156,-0.08792511,0.067544855,-0.03562698,0.009675156,-0.0054931627,-0.063050374,0.004601764,-0.039954055,0.043262966,0.07829902,0.01738332,-0.06140533,-0.012798672,-0.01715737,0.0015305827,-0.024489898,0.01465592,-0.010482554,-0.033840172,0.010718138,-0.010819607,0.039145738,-0.10780075,-0.01857307,-0.054652423,-0.036850486,-0.034300327,0.0017191616,0.017103052,-0.018849822,0.02967528,0.016594958,-0.022733286,0.15012814,0.018693604,0.004859038,-0.057273816,-0.018836116,0.09902509,0.037492175,0.012171401,-0.028439954,-0.0037096627,0.027254565,0.083230324,0.027295848,-0.02368861,-0.033577982,-0.014883737,-0.026261251,0.013749857,0.06519001,0.038026445,0.008741676,0.0010849346,-0.07617318,0.08938843,-0.038950887,-0.04928193,-0.06288978,-0.008788557,0.045976922,0.078518495,-0.02358666,0.001079737,0.0877153,-0.0636022,0.025882516,-0.009318383,-0.031180993,0.115046695,0.03430839,-0.07055591,-0.08997762,0.015363579,0.023703076,0.023908637,0.0071926396,0.102298975,-0.03620818,0.023234334,-0.08702886,3.0826965e-33,0.11142052,0.11461679,0.030834153,-0.038132258,-0.0228997,0.060534142,-0.054217704,0.028872572,0.0420904,-0.08405076,-0.05800855,-0.03274226,0.05210907,-0.02265831,0.006750753,-0.04611635,-0.018094955,-0.080637254,0.082265906,0.0008707993,0.05589167,0.016280532,-0.01326606,0.02356258,0.010690086,0.08436563,-0.016482448,-0.0063594724,-0.005674016,0.03778296,0.019190993,-0.08418342,-0.09922898,0.013659576,0.063803986,-0.016398221,-0.072308846,-0.04623868,0.01659277,0.011186115,-0.00882515,0.046935998,-0.037406635,-0.07030672,0.047934283,-0.03133786,-0.0315381,0.1354892,0.057791546,0.11291383,0.008528204,-0.02505304,0.06970029,0.006635061,-0.05652436,0.021470396,-0.040037755,-0.044246133,0.07619535,0.09855908,-0.017917575,0.07139959,0.00020129002,0.020277286,-0.0032259466,-0.011951683,-0.069505654,-0.0014858712,-0.033663776,0.04398869,0.008850223,-0.024497215,0.05242838,0.015241359,-0.0046482715,-0.030843329,-0.058261093,0.0017833073,0.07368711,0.0008313625,0.03243207,-0.04942791,-0.0058082086,-0.006381662,-0.021609964,0.026453733,-0.04694331,0.008397082,-0.024624804,0.08912168,0.01663193,-0.058207422,-0.011252466,0.0237303,0.01768967,-4.3839647e-33,0.039580572,-0.077895515,0.008839132,-0.073012434,-0.0058283256,0.035627052,0.0038527623,-0.087925516,0.08144158,0.00940038,0.0071924194,-0.022826532,0.04772625,-0.0627546,-3.8999762e-05,-0.002179248,-0.05630182,0.11575176,0.026240382,0.027455807,-0.02888006,0.078417294,0.0045663496,0.06082281,0.11580481,0.021858715,0.004413398,-0.001396808,0.035645936,0.09447397,-0.026541008,0.016478326,-0.018759405,-0.073318765,0.017331598,0.061485793,-0.040793896,-0.02614394,0.080367364,0.029221533,-0.016812697,-0.01646734,0.02664216,0.09475166,0.014561479,0.11767724,-0.07127073,0.09170661,-0.008320661,-0.052402884,0.031803235,0.024455918,-0.045001965,0.033822767,0.004423683,0.017127555,0.053907923,-0.01639917,-0.034843083,-0.023617866,-0.0113723045,-0.06593816,0.026050748,-0.024854643,0.014150158,0.031993188,-0.0073613008,0.022349663,0.0112220775,0.008049838,0.031770725,-0.09125684,0.073177524,0.03802056,0.0055573243,0.025867674,-0.043179676,0.05207457,0.0172809,-0.020358726,-0.002638944,0.031373296,0.059699617,-0.09740195,-0.031149808,-0.11020694,0.03198679,0.09941141,0.00091823656,0.07827002,-0.053284947,0.032583576,-0.062111724,0.04289134,0.052113004,-4.17695e-08,-0.031567916,-0.11573554,0.052265465,-0.058633346,0.0015037651,0.013925648,0.07286087,0.013279862,0.025076209,-0.0042582564,0.03004833,0.13647595,0.049559627,0.002154452,-0.0006527628,-0.010843265,0.034371413,0.05598681,-0.03974077,-0.018724967,-0.11121348,-0.06478649,-0.09158308,0.011331534,-0.038098376,-0.10995876,-0.01599622,-0.017334662,-0.05180996,-0.0634132,0.043577895,0.02331689,-0.006874604,-0.06322769,-0.14012982,0.034151122,-0.0053484864,-0.049111765,-0.020254204,-0.014083623,-0.066699006,0.015314004,-0.029075839,-0.007772381,0.012982614,0.015824843,-0.020808844,0.011599401,-0.039550286,0.014137917,0.017608708,-0.06909526,0.011340535,-0.10667522,-0.07213777,0.04437753,0.03489218,-0.07437294,0.046517096,-0.078250244,0.013398543,-0.012662878,0.17751184,-0.050167255 +1.18.1.8,"This iron-sulfur and flavin-containing electron transport complex, isolated from the bacterium Acetobacterium woodii, couples the energy from reduction of NAD+ by ferredoxin to pumping sodium ions out of the cell, generating a gradient across the cytoplasmic membrane. ",384,0.99999994,-0.11189398,0.01178913,-0.14136665,0.08377347,0.037912454,0.034872256,0.045356188,-0.0038421648,0.041458797,-0.03768832,-0.017713984,-0.051607415,-0.022151208,0.0021362377,-0.054591957,-0.060252957,-0.031156367,0.046126477,-0.02702123,0.054265346,0.01908793,0.03734318,-0.003085484,-0.06603617,0.023560887,0.060207542,0.009258392,0.0014855312,-0.020473914,-0.10003446,0.04179461,-0.015791966,-0.005574324,-0.025632197,0.015932085,0.10498774,-0.030099617,-0.04078684,0.062134992,-0.009196095,0.017265419,0.043481655,0.07822087,-0.027914291,-0.027115632,-0.05521853,0.029041808,-0.004662553,0.06382883,-0.031477895,-0.03429742,-0.019407729,-0.03881557,0.07415338,0.034086306,0.01509604,0.0126493955,-0.100055836,0.019609295,-0.029981734,0.048305064,-0.008996968,0.017543646,0.024724986,-0.034728114,-0.062161453,0.040048666,-0.022042472,0.009045535,-0.059546143,-0.06626431,0.013486821,-0.05432038,-0.013144374,0.0025461903,-0.0045349007,0.01125627,-0.017874172,0.08523888,0.026673673,0.00041774946,-0.016414043,-0.05997288,0.12499582,-0.012418684,0.00029617923,0.0033491072,0.03359764,-0.04605025,0.0354287,-0.017114446,0.011052463,0.007789925,-0.026867157,-0.10901511,0.0053148484,0.06976275,0.034764096,0.035982184,0.033728786,0.016474953,0.10729272,0.0633696,-0.10960604,-0.02502738,-0.049711727,0.01742726,0.17389928,-0.0033725507,0.01355399,-0.002319825,-0.04778966,-0.023972735,-0.06567599,-0.029148165,0.105779886,0.041590963,-0.042967822,-0.051933542,0.05132644,0.011229296,-0.0011167058,0.02487029,0.027338622,0.010783791,-0.013166841,-0.13400124,2.0523206e-33,0.04877644,0.0062489966,0.017097237,-0.012903835,0.031803463,-0.040985215,-0.09405365,-0.05574968,0.023370432,-0.022593936,-0.14564267,-0.034415618,0.04373903,-0.040559135,-0.04976217,0.0007570783,-0.11014339,-0.10480652,0.103760734,-0.00017669583,0.085233025,0.04215149,0.02405668,-0.0037407386,0.06562915,0.024157614,-0.03295555,0.015572361,0.011968739,0.0065803993,0.11492172,-0.051326446,-0.13409841,-0.018720457,0.11102981,0.02762459,-0.043352243,-0.0504124,0.0074428604,0.04606739,-0.022237474,0.021323739,0.0021763665,0.0014199383,0.07587693,-0.039361253,-0.043957178,0.05212655,0.041606117,0.052904535,0.0057262215,-0.084936075,0.080420725,-0.034465846,-0.07781259,0.015274862,0.020003842,0.06273504,0.00978095,0.07103535,0.07240742,0.06587533,-0.009756393,0.053626403,0.017543286,0.06488568,-0.02784208,-0.012916977,0.017024927,-0.033039834,-0.029982666,-0.013070486,0.08819703,-0.044807944,0.091432214,0.051943645,-0.079033345,-0.064168856,0.031120418,-0.021846918,-0.02567192,-0.061755635,0.04001465,-0.034355965,-0.04766127,-0.022040015,-0.033329718,0.022133417,-0.013723234,0.003138609,0.079537496,-0.024911553,-0.06440278,-0.07202878,-0.03296414,-3.7034354e-33,0.0312405,-0.023603085,0.04839668,-0.0993412,-0.055222444,0.09196292,-0.021073705,-0.025260027,-0.007545231,0.076864816,0.081465155,0.023848783,0.035077307,-0.06292012,0.066203766,-0.003336047,0.01690982,0.015146458,0.029741604,0.008485845,-0.009779705,0.022855908,0.0026937013,-0.025219038,0.034655184,-0.018917166,-0.024931684,-0.028575944,0.060240697,0.05932258,-0.036748298,-0.02560162,-0.059371278,-0.11576835,-0.078356095,0.017240906,-0.028795213,-0.0064095985,0.004700067,-0.00045847092,0.0028891796,-0.04996531,0.014473605,0.084636025,0.06258977,0.050291225,-0.08500857,-0.032055378,-0.015681637,0.03409575,0.039610464,-0.008307548,-0.04127458,-0.04705305,0.02465028,0.056990705,0.053739335,0.06822689,0.038232233,-0.06181636,-0.038118944,-0.085667506,0.0013507054,-0.035379738,0.053245284,0.08024373,0.0130471485,0.006209955,-0.007923312,-0.078600116,0.043394614,0.0017872051,0.01893605,0.0076948903,0.02988773,-0.016559517,0.018783508,-0.0064078844,-0.040317476,0.01651445,0.044185158,0.030749109,-0.02748344,-0.098209806,0.09896533,-0.036402073,-0.016431961,0.030240392,-0.030877046,-0.017886465,-0.015557235,0.03284898,-0.025120718,-0.03979603,-0.058595672,-3.074949e-08,-0.024418963,-0.018018879,0.0004240724,-0.07897364,0.04966468,0.036105555,0.010538213,-0.009055039,0.010336027,0.017090693,0.024666017,0.16850892,0.04180921,0.0031331659,0.058493953,0.066588715,-0.040763456,-0.009686527,-0.013432368,-0.059994865,-0.0021162962,-0.027145186,-0.095453516,0.10375383,0.07743676,-0.062452983,0.02864328,-0.08849566,0.025371905,-0.08098592,-0.023189602,0.0687521,-0.007917135,-0.021158522,-0.1357883,0.010705328,-0.035949096,-0.034248736,-0.026365839,0.04502343,-0.01472573,-0.017110473,-0.07189527,0.011031904,0.007602704,0.07936307,-0.029784897,0.063398026,-0.06865441,-0.0035157439,0.029958649,-0.013538848,0.013081235,-0.051833272,-0.10001694,0.056843027,0.001981669,-0.067816,0.0522978,0.020976502,0.034841206,-0.029834924,0.06813045,0.021912642 +1.21.1.1,The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.,384,1.0,-0.04732591,-0.124504685,-0.13080528,0.012236849,0.008630884,0.0054645604,-0.0051550474,0.05032982,0.01258118,-0.04408672,0.016587343,0.008670598,-0.09522941,0.062230792,-0.036362212,0.036162514,-0.056723572,0.008924196,-0.08422513,-0.06399267,0.08566975,-0.027401645,-0.0012054865,-0.017053876,0.019110646,-0.009315655,0.05357547,-0.058445193,-0.018672291,-0.041656848,0.005009969,0.029316802,0.019383648,0.0053720945,-0.0057108635,0.06194932,-0.0837086,-0.09699803,0.01277199,-0.066257864,0.08289319,-0.013513658,-0.04652264,-0.08613505,0.023363357,-0.041206755,-0.06694482,0.037298683,0.09532823,0.045061972,-0.031589888,-0.025344035,-0.05367081,0.067953475,-0.009821925,0.038635995,-0.036835365,-0.008675023,-0.06398179,0.091243885,-0.032137733,0.03916018,0.06395741,-0.018521138,0.10939172,-0.038982835,-0.007991787,0.0065222387,0.029134376,0.023527121,0.016964665,-0.07107389,-0.07247183,0.015850982,0.05114155,0.027518405,-0.015235366,0.05091292,0.0004385727,-0.05707985,0.07334022,-0.0228999,0.11974293,0.1409962,0.0051992596,-0.02410344,-0.049136963,0.0011269319,0.01611871,0.13262266,0.025338942,0.04252839,-0.034700695,0.020072082,-0.0252159,0.06607566,-0.027195862,-0.0014325271,-0.0973068,-0.007613255,-0.015767515,0.026988482,0.024968632,0.003883468,-0.027073793,0.019386591,0.009686305,0.013646773,-0.021015815,-0.06638252,0.009464777,-0.03786092,0.08906541,-0.07780677,-0.014972872,0.07624693,-0.031609956,-0.025619384,0.016482169,0.049422424,-0.01443264,0.077555194,0.0704611,0.09891898,-0.010543783,0.087080136,-0.12387516,7.357271e-34,0.04495285,-0.0009349606,-0.0057260315,0.00795318,-0.040225714,-0.021078039,0.0044400506,0.06608324,-0.013071178,-0.03646838,-0.02440845,-0.048029788,0.074401796,-0.04716762,0.03492394,-0.06538772,0.042968467,-0.010471943,0.04084941,0.0066054803,0.08158944,-0.024063738,-0.042113364,0.005176567,0.07211759,-0.010117646,-0.05010809,0.0015320936,0.04398715,0.027853547,-0.011111267,-0.105932556,-0.07173677,0.012218068,0.061720975,0.021847762,-0.011489848,-0.02497645,-0.0962755,0.11182546,0.036614124,-0.051128913,-0.0560935,-0.058524694,0.036923196,0.02540435,-0.06753672,0.08151361,-0.041128118,0.09625028,0.0632718,-0.024616681,0.10754963,0.022236884,0.007847479,0.03313687,0.017040778,0.017580649,0.065401055,-0.048022673,-0.041809138,0.04743523,-0.07470988,0.053861625,0.02677929,0.040896144,-0.088950306,-0.042148698,-0.006355175,0.071402065,-0.08174438,-0.01486712,0.064418174,0.057123575,0.05522541,0.0041516176,-0.12037989,-0.021471065,0.004199134,0.034011923,0.00084302924,0.003697576,-0.012111436,-0.009609609,-0.03587448,0.00087054475,0.0046822224,-0.07064121,-0.04594386,0.0017002056,0.113994665,0.018141538,-0.027026532,0.009510066,-0.015998978,-1.2329163e-33,0.023980716,-0.121421635,-0.03969027,0.008280182,-0.051245917,0.03418275,-0.013465003,-0.054021336,0.060559556,0.0066247964,0.07592894,-0.035633992,-0.034524582,-0.06039042,-0.02399215,0.057334166,-0.040699586,0.091789715,0.06124271,0.005789404,-0.064595394,0.06847982,0.047441524,0.09446708,0.017594265,-0.0112414155,0.07190003,0.03771111,0.06277522,0.0493776,-0.041184716,0.01919019,-0.017351221,-0.04058105,-0.00943532,0.05458068,-0.029667616,-0.027333423,0.057737973,0.019835498,-0.016191246,0.04829091,0.029010033,0.057255395,0.015952991,0.06993282,-0.052244034,0.058347095,0.047831614,-0.021464992,0.011157962,-0.027436996,-0.017237408,0.08072806,0.0042439336,-0.008673079,0.09026342,0.04169169,0.014088466,-0.0011875733,-0.011343964,-0.089696795,0.03108624,-0.06064201,0.046624456,0.08581329,0.033323526,0.0950128,0.026669089,-0.08343547,0.07504327,-0.06846572,0.012674956,0.03639515,0.0050265864,-0.0022688296,-0.048513755,0.034900825,-0.037540752,-0.057354204,-0.032831863,-0.023858977,-0.026521642,-0.09090983,0.0078110136,-0.07796149,-0.009881943,0.06302169,-0.008938594,0.0014708658,-0.007892221,-0.03722477,-0.07214994,-0.019027399,0.024173047,-2.9867106e-08,0.028925207,-0.048269406,0.028482664,-0.016644694,0.0809407,0.040152375,0.014656962,-0.026948795,-0.03465013,-0.019918144,-0.07074093,0.05983612,-0.07948656,0.045025516,0.06931958,-0.04312898,0.008787301,0.030599816,-0.030981805,-0.07367227,-0.05218534,-0.013722578,-0.10911339,-0.008491703,-0.0063601183,-0.03729538,0.007402415,-0.022302918,0.084800325,-0.054108996,-0.034553587,0.05919369,0.050188825,-0.011846962,-0.13964301,-0.0355544,-0.0060326075,-0.034662947,-0.04417662,0.06877404,-0.040234905,-0.011316543,-0.052749813,-0.044389732,-0.008072343,-0.022882992,0.10132435,0.01337174,-0.041230623,-0.02760628,-0.0063467827,-0.0019604692,-0.016042061,0.036415093,-0.017915437,0.023214879,0.024566982,-0.04422262,-0.032877505,-0.06932111,-0.021431861,0.035635665,0.11717955,-0.030535076 +1.21.1.2,"The enzyme, characterized from Corynebacterium strains able to grow on 2,4-dichlorobenzoate, forms part of the 2,4-dichlorobenzoate degradation pathway.",384,0.99999994,-0.03176643,-0.042889174,-0.042565867,-0.0136043215,0.04700088,-0.024494832,-0.04044953,0.042300455,0.018902157,0.0029421884,-0.011603522,-0.05053279,-0.03538084,0.05042485,-0.04292563,0.12300861,-0.05580366,0.03037659,-0.057279743,-0.024345448,0.063032314,0.010814823,-0.06091877,0.015774313,-0.0014750115,0.0059659737,0.08151067,0.010997894,0.008070587,-0.08824505,0.052646335,-0.0038936918,0.07857971,0.0016227043,0.11499271,0.08138957,-0.04319834,-0.10162869,0.1210144,0.043522134,0.007109802,0.13597353,-0.037083227,0.0026736916,-0.118494645,0.053573787,-0.036834523,0.03419698,0.05957213,-0.038052842,-0.0018578756,-0.009137161,-0.074458286,0.02308346,0.043590214,0.017696636,-0.026368197,0.013975737,-0.012220949,0.038563617,0.06611202,-0.0041553555,0.038085543,-0.00048600262,-0.0719252,0.032942113,0.029974531,-0.039643396,0.077856615,-0.091169655,-0.11973092,0.0014593502,0.0019131828,0.0608391,-0.034904737,-0.007255711,-0.01095857,0.012322933,0.00866088,-0.065776475,-0.018692447,-0.02321624,0.03420227,-0.019531919,-0.013922332,-0.04758222,0.034419067,-0.0997733,0.11659649,0.054346297,0.044153355,0.061661646,0.04706249,-0.09638265,-0.0015669822,0.035177883,-0.024671381,-0.04916086,0.027483074,0.011037039,0.021580627,-0.016465483,-0.023394687,-0.04882066,-0.05984327,-0.04607936,0.0025086922,0.03145466,0.034761768,0.068931974,0.06267567,0.06889061,0.10173298,0.000694504,0.009836891,-0.023998851,0.07376622,-0.025708284,-0.06278606,0.09931506,0.018295143,-0.05621023,0.050263602,0.009664618,-0.07659528,0.06743737,-0.06934006,1.7646611e-33,0.011117568,0.008257034,7.234756e-05,0.03596274,0.0016941678,-0.035804957,-0.03260397,0.009015295,-0.04916212,-0.1266931,-0.03669513,-0.061750732,-0.019118726,-0.057925664,-0.015469203,0.007274876,0.025011452,0.052279145,-0.0071162893,0.06573514,-0.041743696,0.012800349,-0.00024214148,0.013701865,0.0406205,0.05540906,0.036331024,0.01725373,0.04420626,-0.029038468,-0.03150993,-0.07405897,-0.123969205,-0.026726326,0.02320376,-0.033037513,-0.003947697,-0.0118866,0.034013167,0.024560073,-0.00207708,0.009238713,-0.018036103,-0.02775313,0.089211695,0.00767904,0.0135566555,0.07477728,0.0021585093,-0.002108833,-0.0047438405,-0.054338276,0.1161566,-0.047751587,-0.027818603,0.0052976497,-0.020041522,-0.046013787,0.081695184,-0.019314658,0.051839225,0.09247126,-0.07492041,0.040244006,0.012047207,-0.05115904,-0.049823843,0.018966772,0.019545235,0.05033176,-0.032608293,-0.0695149,-0.03039689,0.0057341387,0.017882861,-0.09569387,-0.077693865,-0.031710476,0.028407594,-0.018482815,-0.021448335,-0.0025901226,0.031150313,-0.06427345,-0.10569403,-0.04946823,-0.041031025,-0.047494028,-0.016665272,0.008866518,0.044964656,-0.08725095,-0.057615224,0.05659741,0.0066188583,-2.39601e-33,0.08401743,-0.0386504,0.011939995,0.004994655,-0.0072963024,0.021009091,-0.014087911,0.05147542,0.007720253,0.0012386037,0.05064493,0.014356763,-0.015694048,-0.014322212,-0.012244382,0.060625236,0.08262885,0.092458285,-0.041942377,-0.052982245,-0.035834327,0.030304132,0.0042009642,-0.018350707,-0.016265038,0.037800457,-0.01893162,0.08424964,0.08319753,0.043198783,-0.031225055,0.07966598,0.06175638,0.03594432,-0.10617578,0.0057758624,-0.03945748,-0.05500727,0.022460934,-0.007988169,-0.0029943998,0.0076515777,-3.5977395e-05,0.024609685,-0.021251032,0.0026984313,0.0151313115,0.01312098,0.0475587,-0.047080964,-0.009607894,-0.04696431,-0.026214883,0.034346975,-0.10219378,0.0065467404,0.014491515,0.015426844,-0.0529258,0.009439208,-0.07074371,-0.09520838,0.08983885,0.051722974,0.009804996,0.06486381,-0.012240851,0.10751183,0.038933337,-0.011820206,0.035480477,0.056623057,0.026522538,-0.0194126,-0.055501018,0.066308685,-0.02407375,-0.00903218,-0.043449286,-0.034305774,-0.061481677,-0.024980828,-0.020002438,-0.023357783,-0.05348658,-0.10107647,0.02485741,0.070341505,-0.06738468,0.082044125,-0.030885758,-0.069560796,-0.057017148,0.0787924,0.066162676,-3.025714e-08,-0.02124555,-0.021260269,0.055378042,-0.019072052,0.032733187,0.05765476,0.02361567,0.084873326,0.07585281,-0.03691823,-0.093481794,0.011722822,-0.03135769,0.08018211,0.05348669,0.11771796,-0.120192505,-0.044279702,-0.0033933278,0.04269022,-0.026519751,-0.059279386,-0.03816722,0.06357534,-0.016123138,-0.068063766,0.0064942474,0.056987632,-0.053677723,0.013340154,0.029767897,0.07047695,-0.031211367,-0.036007613,-0.06972199,-0.015846865,-0.041204147,-0.031437475,-0.0026232535,0.08108879,0.0133356005,0.05559428,-0.11443027,0.01786204,0.021465065,-0.011145662,-0.013986918,0.021845935,-0.0078570815,-0.017867988,0.0898212,0.0018800749,-0.10037876,0.010723284,-0.058035377,0.012301418,0.00015620723,-0.020577613,-0.049863264,-0.03764772,0.014951068,-0.017383182,0.18289167,-0.035120007 +1.21.99.3,"The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine. 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+2.1.1.316,"The enzyme, characterized from the bacterium Streptomyces lavendulae, is involved in the biosynthesis of the quinone-containing antibiotics mitomycin A and mitomycin B.",384,1.0,-0.07179675,-0.0031572608,-0.15751387,-0.05440178,-0.009196884,0.019852584,-0.060465757,0.07851232,0.0723512,-0.00767154,0.050860528,-0.052884016,0.06129053,0.034476317,-0.033327222,-0.0003321337,-0.08299847,-0.017672976,0.010658619,-0.08668837,0.07299569,0.06479957,-0.010492461,-0.00806054,0.09175181,-0.022623245,0.01959688,-0.0014159984,-0.08291888,-0.047396902,0.034074187,-0.009259699,0.0042205458,-0.05111512,0.07718964,0.06814123,-0.04490073,-0.034146823,0.15345846,-0.0022003504,-0.053580947,-0.021809421,0.009539491,0.04639723,-0.023382993,0.082740024,0.04073382,0.07788463,0.01459798,0.0056166165,-0.07697528,-0.04695478,-0.06871214,0.067879714,0.07901098,0.072767355,0.027986797,-0.007102584,0.017274512,0.048663966,0.01284975,-0.00988124,0.00427609,0.0337042,-0.11148043,-0.037836548,0.007521513,-0.10071611,-0.0014464577,-0.017464548,-0.037187967,-0.08678954,0.0005056984,0.022459242,0.03626208,-0.013276458,-0.047117367,0.014927005,-0.0824239,-0.0010508965,0.042664945,-0.042092446,-0.0123430975,0.10878642,0.054537747,-0.038903527,0.09840533,-0.01862276,0.116327204,0.072113015,0.04386371,-0.0014890475,-0.04397432,-0.12134917,-0.05420095,0.044731144,-0.07428346,-0.0010029566,0.015718946,-0.009583597,-0.012878428,-0.028373238,-0.0019044876,-0.02798525,-0.04157648,0.00024137442,0.0342017,0.09654532,0.03621631,-0.030665182,-0.00670324,-0.0041129524,0.007980992,-0.057133015,-0.041240644,0.05643629,0.1413996,-0.068909995,-0.040782373,-0.02157238,0.017033137,0.049172074,0.026543632,0.013382524,0.020341035,0.0071376855,-0.09471441,1.6645586e-33,0.019136555,0.040471453,-0.024062527,-0.022407299,0.0020811018,-0.042764004,-0.085471824,-0.011764963,-0.056004178,-0.06827602,-0.073515065,-0.09760943,-0.033453524,0.038623348,-0.0136691965,0.032966908,0.0387549,0.02500988,0.016566757,-0.0005117265,0.037040953,0.017910615,-0.04010473,0.014297275,0.04350121,0.08544737,0.057230577,0.06034493,0.068100475,-0.055229966,-0.016804742,-0.083285965,-0.005168576,-0.011370655,0.058918037,-0.023602279,-0.054017108,-0.017913545,0.034012392,0.0714248,0.022490902,0.023713237,0.0038063957,-0.027259586,0.036190588,-0.038807213,-0.0050678174,0.05823389,0.059457723,0.048250977,0.05995499,-0.0325679,0.12753938,-0.005277843,-0.097137205,0.068736814,0.0055170893,0.036752157,0.047740504,-0.0119779445,0.014416819,0.020642858,0.012295101,0.015843214,0.0634895,0.040263128,-0.07330668,-0.052717377,0.013037509,0.042707644,-0.08664757,-0.04315863,0.06872422,-0.011278948,0.05118901,0.01748935,-0.09783559,-0.03988429,0.055290475,-0.02001578,-0.025991542,-0.020981219,0.0023450435,-0.02904128,-0.0522834,0.0052620154,-0.0367188,-0.08401998,0.010236519,0.016619228,-0.025223974,-0.11667692,-0.06319988,0.009162998,0.036704082,-3.0926092e-33,0.043889552,-0.04978434,0.082446225,-0.017078554,-0.03662557,0.07677878,-0.065088436,-0.049690906,-0.008684586,0.005514529,-0.0032050405,-0.04599253,-0.030125605,-0.06158753,-0.025738927,-0.044098884,0.058939364,0.029769022,-0.018194169,0.055540696,0.016463185,0.06777048,0.062237013,-0.054139074,0.027395807,0.017996695,0.033003893,0.12162762,0.047580592,0.019333802,-0.042227585,-0.04313993,-0.0059121605,-0.033060856,-0.05259204,0.1084647,-0.041592885,0.026442898,0.07453772,-0.039036788,0.04061328,-0.034189325,0.017817046,0.08535358,-0.0066039944,0.010743761,-0.06372678,0.045005225,-0.026193935,-0.07511754,-0.021991597,0.09087151,-0.021918075,-0.035508886,-0.016927911,0.016572436,-0.005202892,-0.030834006,0.042719238,-0.045246575,-0.0630185,-0.063835025,0.040046606,0.033561286,0.046222243,0.056730434,-0.09527332,0.052119777,0.0828562,0.010066864,0.050967753,0.0058058687,-0.04749018,0.010995409,-0.02582175,-0.0052212663,-0.062804885,-0.06635546,0.025031205,0.03653453,-0.009468574,-0.030949885,-0.027057685,-0.019494718,-0.041711118,-0.06960873,0.02796352,0.040812824,0.0346979,0.02155645,0.0030976953,0.04125031,0.011033416,0.066588566,0.0014575451,-3.0319743e-08,0.032923255,-0.011890292,0.04437768,0.031367846,0.02609344,-0.049403872,-0.0104186,-0.0074427146,0.025806075,-0.008691189,-0.056400135,0.0013970087,-0.03370077,-0.018681012,0.03517306,0.07228429,-0.0919184,0.006165754,-0.00954535,0.044108115,-0.025756609,-0.008646471,-0.12152605,0.025036337,0.03558359,-0.05883095,-0.0027560575,0.015500236,-0.06360273,0.017152134,0.0069337245,0.018141229,-0.06535163,-0.03566753,-0.049583558,-0.038600076,-0.09124335,-0.013223353,0.035047147,-0.02844856,0.06406901,-0.0077550234,-0.10317089,0.057571173,-0.07926862,0.04656286,0.008338033,-0.039468978,-0.0060838596,0.0295467,0.06770955,0.018673709,-0.0016168435,-0.011398374,-0.104690515,0.030557966,0.046865493,-0.050468273,-0.040132023,-0.04436942,-0.023006493,0.011809202,0.21464284,-0.03230774 +2.1.1.317,"The enzyme, characterized from the fungi Komagataella pastoris and Fusarium graminearum, acts only on ceramides and has no activity with free sphingoid bases or glucosylceramides.",384,0.99999994,-0.009577362,-0.07736438,-0.10131674,-0.047246322,0.05997837,-0.013429233,-0.09115557,0.017687501,0.065497026,-0.024512058,0.078663036,-0.09039409,-0.04600418,0.032986693,-0.007972934,0.0059219906,-0.0040849317,0.059074894,0.030189928,-0.024598835,0.048927195,0.002185288,-0.0106685655,-0.001373311,0.017020334,-0.014821276,0.025910158,-0.033552494,-0.02542775,-0.059058756,0.0033464662,0.039625663,0.055493567,-0.020354465,0.03528386,0.07029309,-0.056677718,0.013100679,0.08186512,-0.03182886,0.0053986576,0.0023911565,0.021909842,-0.05961699,-0.025417127,-0.027391197,-0.028093101,0.0306287,5.6254346e-05,-0.032509983,-0.028078847,-0.09599036,0.009117166,0.05133335,-0.06549261,0.022211296,-0.071816005,0.017372863,-0.057323907,0.04026233,-0.021068562,0.017716086,0.0036080861,0.02800927,-0.046313684,-0.028057273,-0.026711041,-0.042309385,-0.012620185,0.017900545,-0.008328004,-0.062099952,0.08361171,0.033626117,-0.019590514,0.048761386,-0.0017216663,-0.04486863,0.04201657,-0.032569237,-0.018873205,-0.027959812,0.07422844,0.054064155,0.04459275,0.016232071,-0.0032489472,0.087040536,0.05696138,0.0021455735,0.08063935,0.05348551,-0.0009854985,-0.05578597,-0.033266913,0.052860007,-0.030906882,0.06053681,-0.06489283,-0.020160412,0.013236057,0.04107885,-0.004520135,-0.06528031,-0.030567346,0.06313563,-0.0080735665,0.052913528,-0.02367799,-0.05966659,0.010853615,0.01680983,0.054628663,-0.044643424,-0.041160323,-0.050256476,0.06849828,-0.0796682,-0.14368643,-0.008713644,0.0019968508,-0.025728218,0.047533125,0.03700835,-0.09142395,0.053909488,0.0026206593,4.9808293e-33,0.04002513,0.018496841,0.029313765,-0.097887605,-0.044365253,-0.043848746,-0.034389302,0.00966156,-0.08138619,0.02127681,-0.09375273,-0.0026830323,0.0071433526,0.011198243,0.06289305,0.053871963,0.05972821,-0.033129193,0.118008256,0.001382851,0.050215606,0.034002826,-0.052091014,-0.012404223,0.055650238,0.043777455,-0.01671454,-0.015490342,-0.029734425,-0.012456889,-0.04089623,-0.036718212,-0.07390305,0.07109117,0.04012894,0.050552495,-0.05749979,-0.007267308,-0.092285074,-0.019467445,-0.020072771,0.034730878,0.015565391,-0.026101097,0.02180912,-0.0183184,-0.037736923,0.05491001,0.05702074,0.09373676,0.07365659,0.015799306,0.07110312,0.029244363,-0.0072696065,0.05428277,0.03168265,0.025322597,0.020562854,0.049643658,-0.090192206,0.018636338,-0.09750968,0.031568103,-0.024734162,-0.0063243443,-0.055789456,-0.06759003,-0.07690399,0.01802305,-0.021960659,-0.011543673,0.013845134,0.07277583,0.0040635206,-0.055085402,-0.021591065,-0.08500845,-0.058685906,0.040696252,0.04957008,-0.12249462,0.01196031,-0.04218932,-0.024567602,0.023390217,-0.076451056,0.049361352,-0.0062869466,-0.04996184,0.047879443,-0.06592344,-0.06941603,0.08617119,0.045333833,-5.7238758e-33,0.036486324,-0.07005497,0.005066798,-0.044931304,-0.063258536,0.12399435,-0.021921054,-0.0025789642,0.04375275,-0.022919197,0.013194928,-0.0025737826,-0.064870305,-0.030921191,-0.008233102,0.04620701,-0.023576839,0.059612636,-0.03981471,-0.029531308,-0.014791248,0.15073419,-0.06181683,0.045706674,0.046847608,0.073013626,-0.013903483,0.11709407,-0.0007027469,0.072882645,-0.011271528,0.028888946,0.01497678,-0.06462611,0.03412901,-0.017999014,-0.042316318,0.013547403,0.043151185,0.02014746,-0.04600207,0.10110061,0.011263156,0.112637855,0.065359026,0.0873593,-0.088364,0.06922823,-0.0140419835,-0.032642227,-0.053328685,-0.003646071,0.02359737,-0.051520094,0.110365994,-0.0008125429,-0.021964408,-0.033936888,-0.052023698,-0.06412977,0.006373928,-0.07055276,-0.054907694,0.008948113,0.08650671,0.09093774,-0.013729217,0.08436496,0.028213203,0.0031715895,0.015880398,-0.017893866,-0.053538345,0.036934253,-0.02802168,0.06301387,-0.05020311,-0.044463303,-0.0019921507,-0.013869097,0.08765693,-0.009435734,0.09688798,-0.07605438,0.068569176,-0.018288411,-0.024593668,-0.015217972,0.010828803,0.04061411,-0.017300555,0.039573997,0.061897546,0.04256203,0.073352404,-3.469844e-08,0.083008915,-0.0038258503,0.023149177,-0.11741387,-0.020285457,-0.02466484,0.023950338,-0.044144224,0.0658069,-0.013682651,-0.0995944,0.06715746,-0.024898384,0.08506121,0.03668543,0.019152684,0.0030166465,-0.038645398,-0.059143193,-0.031769134,-0.05844768,0.005264133,-0.10097068,0.053414285,-0.03604709,-0.03816766,0.0373779,0.0387537,-0.004522166,0.074679814,-0.03664484,0.028207257,-0.029053535,0.010160734,-0.04203652,0.077408485,-0.04416292,-0.048166536,-0.052894063,0.044710685,-0.0011766629,-0.06420673,-0.025859239,-0.018662794,-0.0496374,-0.007779619,0.032696787,-0.018213706,0.047250755,-0.021429624,0.01610431,-0.004229,-0.08166101,-0.031114677,-0.1439331,0.00043383575,0.030534629,0.0106486725,0.021780692,-0.14821161,-0.005620597,-0.0688597,0.14239742,-0.013940994 +2.1.1.318,"The enzyme, characterized from the yeast Saccharomyces cerevisiae, enhances the activity of EC 2.4.1.15, trehalose-6-phosphate synthase, resulting in elevating the levels of trehalose in the cell and contributing to stationary phase survival. In vitro the enzyme performs S-methylation of L-cysteine residues of various protein substrates. ",384,1.0,0.005997034,-0.036474206,-0.06503609,-0.065941975,0.052337147,0.0685576,-0.04997185,0.03184074,0.009225707,0.02138597,0.019133389,-0.014339994,-0.04006801,0.0016010413,-0.055442933,-0.012240086,-0.033072323,-0.018211037,0.00033043526,-0.05775111,0.088107765,0.0050313114,-0.031739857,-0.00053679297,0.067806624,-0.046852734,0.006855949,-0.032833703,-0.032519944,-0.035423808,-0.08388452,0.014515281,0.03170614,-0.00067301973,-0.0016458435,0.14279148,0.0059889643,-0.036428697,0.025746742,0.0077305716,0.013480598,-0.040642664,-0.073523276,-0.0040173223,0.00918919,0.01001282,0.07953134,0.017177362,-0.033526614,-0.033403557,0.0047620437,-0.07911379,0.02815332,-0.013629036,-0.03777837,0.046241906,-0.037614282,0.019828752,-0.029387707,-0.008833808,0.05653788,-0.028289335,-0.032556,0.0069732713,0.04369791,-0.11935223,0.07499887,-0.04657959,-0.024979115,0.009886445,-0.08673213,-0.04082307,-0.016248232,0.05863869,-0.061069265,0.045258284,0.0095917545,-0.15588851,0.027822876,0.036453042,0.08526667,-0.027540512,0.0029800963,0.03594091,0.07148659,-0.10029219,0.039893337,0.08491028,0.046863385,0.059731677,0.04950099,0.025931893,0.030284397,0.025921173,-0.09951829,0.07671573,-0.0447038,0.04462487,0.081025735,-0.062037252,0.030274255,0.06162929,0.01558985,-0.0055969735,0.06759897,0.008987478,0.0033632873,0.13326757,-0.018377552,0.014250996,0.045530185,0.046374857,0.08471248,0.019729435,0.0015735982,0.082124494,0.0073590493,-0.07254731,0.0029412017,-0.007985231,0.055812236,0.06518168,0.031970087,0.052578866,-0.021673298,0.049165245,-0.056313697,3.140349e-34,0.07571772,0.078707516,-0.00906878,0.014109948,0.039855625,0.0029964652,-0.057615586,0.03257475,-0.0694807,-0.016697232,-0.071406655,-0.08022746,0.035626274,0.025970722,-0.037943747,-0.009006122,0.02949132,0.02297446,0.06941979,-0.061667997,-0.059775654,-0.04120013,-0.07225734,-0.00879303,0.007562695,0.032976538,0.032422174,0.013279181,0.029870536,-0.01636616,-0.019339709,-0.07176439,-0.027143287,-0.023545198,0.105588295,-0.00018854345,0.013644091,0.06597587,-0.0035944323,0.038191553,0.0657235,0.03372407,0.03594641,-0.059645366,0.0055321213,-0.07709099,-0.09937357,0.10707598,0.019755153,0.036838815,0.027176123,-0.049328987,0.0684343,0.01273195,-0.011185136,0.051359996,-0.021682348,-0.02095015,-0.035577234,-0.01116611,-0.046082392,0.014855523,-0.06506988,0.069594726,-0.02205424,-0.014003499,-0.03357995,-0.11803336,-0.103043035,0.055350624,-0.08789254,-0.04769265,0.10364609,-0.02091869,0.024081798,-0.047894623,-0.082251,0.020524645,-0.03642701,0.062341645,-0.006075949,-0.048633255,-0.044327002,-0.034338374,-0.03573117,-0.051899537,0.01936322,-0.029860783,0.012190476,-0.011469792,0.029160695,-0.07361345,-0.034275062,0.041845262,0.015559977,-1.3457583e-33,0.076854356,-0.0419502,0.07256102,-0.07690112,-0.04908116,0.06763928,0.03629808,-0.054071374,-0.0038705696,-0.102358066,0.09999997,-0.038408674,0.0057816026,-0.02480696,0.009651445,-0.039148375,-0.043854054,0.08020078,-0.031333074,-0.01717406,-0.019926384,0.04898637,-0.031140612,0.0952897,0.083099104,0.0031045931,0.014677284,0.09336616,0.0092877075,0.04038576,-0.0076516196,-0.091005266,0.0034945114,0.012447922,-0.055868,0.07059192,-0.045536496,-0.047832765,0.02929774,0.069421984,0.051540956,0.045483742,0.024036389,0.051662296,0.039563708,0.04816294,0.004753889,0.0055537988,-0.00981868,-0.08150763,0.022884471,-0.022920793,-0.025997765,-0.008178106,0.07865796,-0.007715197,-0.03494554,0.011899587,-0.025386646,-0.037029333,-0.024905302,-0.042536993,0.0128105385,-0.02558754,0.033355698,0.022918953,-0.091259,0.050354254,0.019268991,0.01418303,0.034902114,0.029802635,-0.043967515,0.013755599,-0.05866637,-0.07116914,-0.12405254,0.049886316,-0.009041633,-0.036080137,-0.015713837,0.041889414,-0.0072973017,-0.035832774,-0.017807595,-0.04366407,-0.006287166,0.11424165,-0.041881807,-0.0074749845,-0.09749732,-0.058112215,-0.052782238,0.08540368,0.063651524,-3.688674e-08,0.09057557,-0.041003376,-0.032728076,-0.1135632,-0.026384477,0.08294389,0.06288286,0.033076588,0.07055333,-0.02034293,-0.019668255,0.04567576,0.054085556,0.07666868,0.012189764,-0.006081622,-0.025820062,0.034247257,-9.279464e-05,-0.01927684,-0.0059610875,-0.008041411,-0.10116839,0.02811724,0.0342989,0.0070050834,0.026656395,0.090926096,0.0059922393,-0.003024155,-0.011059638,0.032662157,0.027751608,0.0807343,-0.05387802,0.06501895,-0.08008868,-0.0354213,-0.03093471,0.06791595,0.013738834,-0.027378403,-0.11875609,0.029895866,-0.04477124,-0.018198347,0.04766069,0.08034328,0.02009084,0.017589567,0.0017593441,0.0356621,-0.052085288,-0.049654156,-0.025735091,0.030016888,-0.01763134,-0.07189287,-0.034658257,-0.074773684,0.06809726,-0.015647365,0.09742114,-0.13830726 +2.3.1.248,"The enzyme from the plant Arabidopsis thaliana has no activity with 4-coumaroyl-CoA (cf. EC 2.3.1.249, spermidine dicoumaroyl transferase).",384,1.0,-0.05364581,-0.04500804,-0.09340504,-0.04754952,0.06317571,0.050034583,-0.11796145,0.009170817,0.087611035,0.034202464,0.09099587,-0.092884295,-0.098476164,0.010163135,-0.0057698213,0.010908644,-0.030434648,-0.0015237917,-0.012408757,-0.09232013,0.03718364,0.05460374,-0.017966436,-0.005724376,0.06110608,-0.0039923787,-0.056021854,-0.02439541,-0.0055650775,-0.077033855,-0.06453476,0.05153608,0.008311711,0.00760441,0.016862331,0.08036781,0.021056632,-0.12141037,0.071263805,0.019566024,0.1011551,-0.04081987,-0.036071565,0.00837204,-0.11445769,-0.012179415,-0.013073205,-0.004480698,0.06590542,-0.0191944,-0.05877468,-0.024151249,-0.040242612,0.018236414,-0.0014865495,-0.0049310955,0.046641994,0.0041844384,0.027705219,0.11099058,0.030605517,0.00643649,0.023171743,0.0038062667,-0.0048317,-0.024631986,-0.031079182,0.021496043,0.04167328,-0.03597024,-0.02656812,-0.02885451,-0.041611042,0.003945098,-0.033570953,0.049310192,-0.06628671,0.029662628,0.040196568,-0.040511385,0.0014017029,-0.024980133,0.026333882,0.03966091,-0.009771378,0.009372202,-0.05224794,0.0017726879,0.04906674,0.0040981434,-0.004068361,0.04309859,-0.012266456,-0.030561466,-0.056370445,0.094091505,0.028899793,-0.031663656,-0.09980642,-0.036752895,-0.007588197,0.06750875,-0.01958708,-0.050376076,-0.057232466,0.01303131,-0.011603105,0.010049003,-0.005903364,-0.009372804,-0.022455387,-0.009668303,0.0105004,0.023512527,-0.008534705,0.03094772,-0.044505667,-0.055853598,-0.06719293,0.039588172,-0.019414557,-0.045078643,0.07304908,-0.0014252245,-0.031084504,0.011492277,-0.05471543,1.1866144e-33,0.10931636,0.06883211,0.022231095,0.04466554,-0.023742085,-0.02296925,-0.037011847,0.07637739,-0.021384256,-0.08443887,0.005338728,-0.03728427,0.022325445,0.009519324,-0.028529964,-0.012845444,0.018370626,-0.09820635,0.07884252,0.056486562,0.053900227,0.007527447,-0.10152327,0.06450713,-0.024455424,0.05519166,-0.023884716,0.0010213671,0.09763083,-0.0009854687,-0.038093943,-0.058808044,-0.0013452601,0.013337579,0.053379487,-0.032607727,-0.10760651,-0.0316125,-0.094250605,0.05174934,-0.015681678,-0.011195818,-0.027214693,-0.06261939,0.028937511,-0.04854683,-0.02496156,0.011472827,0.012384991,0.08720067,0.016118757,0.047152065,0.09655156,-0.07884288,-0.027970204,0.034909423,0.007125139,0.023549715,-0.026153937,-0.012044303,-0.015155435,0.018222699,-0.03788029,0.06309352,0.018606793,0.10007559,-0.12188924,-0.11874617,0.006767597,0.110705405,0.0057841726,-0.040193807,0.0098100705,0.016910309,0.09900485,-0.04699338,-0.048548274,0.011305629,0.0013844126,-0.008740906,0.040227596,-0.03155517,0.032295417,0.013623628,-0.060692027,-0.016552595,-0.0070963856,0.029220147,0.0037905194,-0.013092396,0.09229355,-0.039595257,0.025166895,-0.026552767,0.07491796,-1.4508355e-33,0.09671469,-0.041835777,0.043067407,-0.073269114,-0.065556474,0.11851258,0.06553511,-0.027210355,0.039243966,0.019682536,0.16383438,0.04663647,-0.028849287,-0.04982262,0.016214656,0.049964227,0.05003308,0.0063410588,-0.021096935,0.039486874,0.0056173042,0.051655896,0.07754543,0.0039644428,0.051979974,0.00072506827,0.040741872,0.021664437,-0.04528484,-0.015178508,0.02761009,0.009137626,0.0076791258,0.005466229,-0.08073909,-0.04684211,-0.04854037,0.031658873,-0.057595406,-0.031214558,-0.027694652,0.017057864,0.018109187,0.08381478,-0.011003493,0.0019755526,-0.09606145,0.047720432,0.00928914,0.02366549,-0.035627346,0.043912604,-0.13044429,-0.0049055354,0.040585756,0.0069106715,0.0990862,-0.01357979,0.010491943,-0.030699592,-0.06513038,-0.031239944,-0.044953335,0.037425872,0.10206467,0.0816267,-0.004624052,0.09460081,0.035532042,0.02160624,0.10655728,0.024770204,0.07353269,-0.028103402,-0.030316042,0.0046708044,-0.030171975,-0.039763678,-0.08265123,-0.024291186,-0.048652735,-0.0020672814,-0.03888567,-0.0656442,-0.036116507,-0.06865627,0.027095916,0.083308086,-0.008939619,0.101076744,-0.040455937,-0.018090429,0.02228651,0.04693493,0.10101795,-3.209392e-08,-0.017143484,-0.0044690627,0.047658417,-0.07587852,0.04812936,0.057695728,-0.02633435,-0.012836473,0.065634094,0.06186756,-0.06538071,0.017628605,0.015891148,0.065159135,0.049572688,-0.026372792,0.076064944,0.03851545,-0.009584655,-0.028773976,-0.055413697,-0.015713643,-0.11129386,0.05123318,-0.026706716,-0.027271613,0.053200953,-0.012173803,0.041540124,-0.02434914,0.016688734,0.054438397,0.042679787,-0.042600866,-0.13368917,-0.022474226,0.07088376,-0.0036616747,-0.10306354,0.03940823,0.010989016,0.034944527,-0.053623907,-0.015558214,0.0153457085,0.016871026,0.06759233,-0.02487072,0.02756314,0.089775145,-0.013787809,0.028531037,-0.03251256,-0.046290163,-0.05400543,-0.048943583,0.025590796,-0.051264033,-0.052835852,-0.07246757,0.026282676,-0.057255045,0.14369257,0.0027016893 +2.3.1.249,"The enzyme from the plant Arabidopsis thaliana has no activity with sinapoyl-CoA (cf. EC 2.3.1.248, spermidine disinapoyl transferase).",384,1.0,-0.112151355,-0.040336058,-0.08835492,-0.01905999,0.062053263,0.011464324,-0.12360377,0.0031550932,0.052104767,-0.0074747377,0.09782346,-0.08602932,-0.06239785,0.016078167,0.020727815,0.011945165,-0.025333919,0.011129595,0.023270437,-0.060456306,0.031171856,0.08096053,-0.016195187,-0.057442702,0.034634497,0.031295624,-0.038454592,-0.02594414,-0.014973299,-0.10132666,-0.08136895,0.06273743,0.055143338,-0.038003206,0.0067764674,0.101002775,-0.029604953,-0.09406784,0.065446384,0.026797991,0.089574166,-0.030503072,-0.046673506,-0.020205153,-0.116659656,-0.03524756,-0.0016304825,-0.010897453,0.024986915,-0.0023959607,-0.05959587,-0.025946867,-0.024128636,-0.01512311,-0.046124324,-0.02357735,0.06678094,-0.013600586,-0.017812422,0.073648445,0.033102512,0.029285936,0.0032232562,-0.012827826,-0.022848394,-0.031616442,-0.015402783,0.031993035,0.04353071,-0.044538263,-0.041489616,-0.038880732,-0.029805293,0.07546681,-0.031021789,0.022195779,-0.029225335,0.06893528,0.048072446,-0.026142433,-0.073797904,-0.057730004,0.0038942343,0.07540236,0.022045255,0.084033,-0.08711859,0.03785719,0.027274007,0.019549811,0.030010996,0.08043173,-0.053380657,-0.030624611,-0.0039830683,0.065425515,-0.0044877077,-0.0075315153,-0.14428577,-0.017856507,0.011509717,0.06649929,-0.05011527,-0.0818191,-0.015390401,0.0063858344,-0.012508729,-0.04919042,-0.018891377,-0.05404889,0.017357567,0.01584955,0.047346134,0.03166153,0.0047205305,0.024020888,-0.046642452,-0.02176479,-0.05059296,0.052016757,-0.0147193875,-0.047624264,0.039445564,0.034118157,-0.07900836,-0.022964822,-0.08033422,1.9852481e-33,0.06454872,0.0760117,-0.025124386,0.0131059,-0.03000268,-0.028625095,-0.013807282,0.07111319,-0.01963776,-0.053589426,-0.03112789,-0.021643355,0.017462842,-0.0023606722,-0.012626258,-0.022325402,0.026947841,-0.06084855,0.06019942,-0.010863209,0.058495354,-0.04408691,-0.04716113,0.024915133,-0.030469444,0.0669138,-0.020949228,0.0048235157,0.08044073,-0.001450346,-0.014221859,-0.084219255,0.005247714,0.010334124,0.0684092,-0.046939995,-0.077520184,-0.038129445,-0.1103447,0.060205072,-0.0023346506,0.008162592,-0.015649963,-0.020002533,0.004024527,-0.04177324,0.0030784796,0.066873685,0.065096475,0.07371127,0.039396808,0.0006673032,0.11084421,-0.11748683,-0.032582927,0.028179428,0.010943369,-0.0053905295,-0.07605225,-0.0006803752,-0.026216662,0.00011945191,-0.017553568,0.0069760308,-0.010472535,0.122271396,-0.12716404,-0.11407064,0.012299717,0.08743405,0.031270754,-0.011201989,-0.011344055,0.048094515,0.07338924,-0.057151902,-0.053029124,0.062414885,0.036593594,-0.00015660451,0.0803233,-0.024602197,0.02116143,-0.050938714,-0.032141954,-0.008965383,0.054942932,0.005904521,-0.006658408,0.033947308,0.09662834,-0.009674258,-0.011762554,-0.013869694,0.08022232,-1.9965805e-33,0.040460337,-0.041712265,0.021649975,-0.10546836,-0.072764084,0.06585489,0.071108855,-0.014777007,0.054401435,0.0073285033,0.10206477,0.015331407,0.017389301,-0.04732736,0.021222439,0.06536941,0.05604176,-0.024765242,-0.013447466,0.004803435,-0.049851544,0.06288042,0.06531284,0.016390337,0.022193383,-0.011604283,-0.0030744334,0.023341496,-0.0035810368,-0.014508429,0.0189813,0.040224854,-0.022886215,-0.0035490347,-0.053095352,0.023875713,-0.03949244,0.04867001,-0.027381158,-0.042196345,-0.03450322,0.017018015,0.012966543,0.10707652,-0.019534089,-0.009006805,-0.06620372,0.026773807,-0.056827597,0.024013698,-0.0013834725,0.032206986,-0.060941286,0.016927628,0.02979404,0.037161093,0.07100246,0.019619875,-0.028440392,-0.075526975,-0.027094439,-0.065343395,-0.07012926,0.039598297,0.10641524,0.10739308,0.02289393,0.08117022,0.020453084,0.039738197,0.119796805,0.014381064,0.06390904,-0.08102319,-0.054816227,-0.0011722196,-0.0235603,-0.011280391,-0.10063841,-0.06952549,-0.019780058,0.033920676,-0.07442507,-0.06657855,-0.031057231,-0.0475271,0.015151832,0.07666651,0.00083521643,0.0990463,-0.0505206,-0.02500628,0.003127022,0.088275015,0.12643348,-3.0280468e-08,-0.022923216,0.007042465,0.01754231,-0.049821466,0.05900179,0.046056926,-0.002932673,-0.020799289,0.062566504,0.073690556,-0.09840413,0.0467126,0.038431723,0.029384248,0.053491045,0.0043804385,0.053363476,0.081179455,0.025073284,-0.04458689,0.04030109,0.023857879,-0.08068283,0.056874216,-0.008094281,-0.017517323,0.044862892,-0.029780943,0.043716867,-0.027795838,0.036869124,0.0020321195,0.019128015,-0.04787551,-0.085057475,0.013202545,0.050606206,-0.019981708,-0.06660335,0.040810093,0.018194895,0.07042919,-0.06426353,0.016597144,-2.1744518e-05,-0.038934663,0.031891745,-0.020690612,0.068151735,0.06844932,-0.0035102062,0.032160677,-0.016484872,-0.077290766,-0.09576868,-0.02669608,0.037884265,-0.021459928,-0.045885857,0.0141992085,-0.0022263518,-0.027916936,0.15848923,-0.034182392 +2.3.1.250,"The enzyme, found in animals, modifies a specific serine residue in Wnt proteins, e.g. Ser209 in human Wnt3a and Ser224 in chicken WNT1 [2,3]. The enzyme can accept C13 to C16 fatty acids in vitro, but only (9Z)-hexadecenoate modification is observed in vivo [1]. cf. EC 3.1.1.98, [Wnt protein]-O-palmitoleoyl-L-serine hydrolase.",384,1.0,0.014993238,-0.07535187,-0.07608086,-0.02702634,0.09026348,0.036144506,0.020943085,0.05993579,0.03986951,-0.04437429,0.0017177981,0.025143538,-0.11333675,0.023504166,-0.018528016,-0.029672377,-0.065128945,0.017958967,-0.028262697,-0.047209665,0.10145523,0.06377153,0.104942374,-0.059272423,-0.04166375,-0.0019543865,0.012034412,0.008340396,0.07832175,0.0026774202,0.0339777,-0.01457822,0.002721625,0.0037883476,-0.019915499,-0.02469322,0.00036967918,-0.043322366,-0.026189685,0.027041389,0.101624034,-0.029695556,-0.06874149,-0.0039128647,-0.014471503,-0.1079571,-0.051242117,-0.02097825,-0.0018103516,0.07391301,-0.05724616,-0.087526925,0.0040962463,0.01469425,0.014540159,-0.08115377,-0.01819104,-0.015789494,0.027256219,-0.05079249,-0.019959811,-0.0009970412,0.07611167,-0.07660101,0.12312729,-0.06885837,-0.026937533,-0.07783421,0.020793054,-0.07812792,-0.07340154,-0.044997208,0.011279214,0.03876891,-0.07308562,0.10166356,-0.05027956,0.022916017,0.06063715,0.023116035,0.030668624,-0.0038247844,0.043225504,0.120359935,0.09230547,0.020735124,-0.09952786,-0.001564949,0.04570003,0.010301776,-0.000836528,-0.07658121,-0.09856377,0.055774607,-0.023720488,0.00025408546,0.038311332,0.021215396,-0.017775247,0.022563355,-0.022815792,0.014187268,-0.048927,-0.055778,-0.04430667,0.04160201,0.018709864,0.13480344,-0.05602939,-0.083783425,-0.07536221,0.0029236001,0.017445661,0.020810856,0.01977485,-0.010486274,0.019418256,-0.047785092,-0.081574254,-0.07612442,-0.008143956,0.0077401167,0.110665806,-0.011005157,0.025066346,0.04245209,-0.019008491,2.0784806e-33,0.07987761,0.026242448,0.044105772,-0.04181428,0.012291569,-0.067896545,-0.08702028,0.011947277,-0.001056701,-0.03782296,-0.02942462,-0.021792991,-0.019217031,-0.04455698,0.054896854,-0.07383739,0.0376525,0.04456307,0.113601826,-0.0024022076,0.029988157,0.06616071,0.04493713,-0.0015294092,-0.0050304895,-0.043560877,-0.09161757,-0.051677674,0.04906642,0.0076599405,-0.032823578,-0.06650438,-0.048359904,0.018004538,-0.022246903,0.0067149447,-0.03383754,-0.07494263,-0.023659486,0.017595727,0.12618968,-0.059700634,0.049834646,0.004785748,0.031393904,-0.045904785,-0.010206438,0.049180992,0.030621547,0.0020772915,0.012768574,0.030239044,0.07314538,-0.057823434,-0.09232435,-0.0012818954,0.03970801,-0.0063104816,0.052066397,0.068673335,-0.090874046,-0.024432339,-0.027851135,0.07251421,-0.009348619,-0.065082885,-0.119091205,-0.0075187245,-0.07994901,0.15365799,0.023985047,-0.041648746,0.079875454,0.0036995113,0.024825284,-0.038775615,-0.024926888,0.09277552,-0.026994882,-0.019804943,0.08883969,0.07881368,-0.05743739,0.035507955,-0.08129061,0.065573685,-0.031647436,-0.089561805,0.044898923,0.017357236,0.07487858,-0.030598784,-0.05292097,-0.03213993,-0.007980437,-2.6569352e-33,-0.01249246,-0.03429875,0.03403146,0.01438882,-0.060946763,0.05258374,0.06336778,0.0045017353,0.018038763,-0.067312896,0.10595018,-0.041960906,0.0257019,-0.07249077,-0.042872883,0.03996673,0.006196072,0.07024232,0.037094567,-0.062433325,0.04458434,8.783558e-05,0.042753838,0.08714239,0.029554827,0.047665093,0.03986068,0.060123183,-0.027116442,0.0032314726,0.03398573,0.033199456,-0.008097783,-0.060658976,0.022500502,-0.019671323,0.00082299736,-0.0042701536,-0.0012954817,0.032540444,0.01568416,-0.033494327,0.043828376,0.03384257,0.05114872,0.03228385,-0.045366216,-0.0367354,0.009567722,0.002503331,0.024140019,0.026476806,-0.01668803,-0.025939452,0.063268356,0.12982027,0.040106364,-0.01594381,0.037414595,0.048080657,0.009209765,0.0679269,-0.015965622,0.054135755,0.035968877,-0.03398722,-0.013834023,0.013890048,0.055215545,-0.041998643,0.019992588,0.034988876,0.07432389,0.07923017,0.061402377,-0.0030808337,0.0039219377,0.011621088,-0.043174263,-0.051315404,-0.033998687,-0.0013260746,0.012095664,-0.121109225,-0.0070349993,-0.02734919,0.012945274,0.103850886,-0.04240448,0.012919554,-0.04163186,-0.05937583,-0.10292049,0.016067136,0.03161114,-3.9951345e-08,-0.049808934,-0.087095186,0.019869642,-0.027218726,-0.05972889,-0.021098249,0.009536712,-0.05031582,0.029236203,-0.05905653,-0.0028348065,0.019097613,0.010584769,-0.011410027,-0.016366383,-0.019698856,-0.056320127,-0.028577665,-0.014015028,-0.088571645,-0.044145912,7.099457e-06,0.039042145,0.05589294,0.036588866,-0.012120865,-0.032188747,0.120631434,0.0049108854,-0.02098467,-0.020930171,-0.023643892,0.023866648,0.028698996,0.01329529,0.011764464,-0.029831821,-0.028830051,-0.015593681,0.11437587,0.008413024,-0.0016409137,-0.06069466,-0.013605665,0.047949705,0.06846986,-0.06882115,0.087005265,-0.023331396,-0.06364937,0.023742536,0.018168176,-0.01795479,-0.020720962,-0.059848428,-0.0048695495,0.005571434,-0.065479055,0.04818112,-0.0688644,0.0038389377,-0.03378649,0.14589301,-0.036007077 +2.3.2.23,The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.,384,0.99999994,-0.06212013,0.025728911,-0.056294464,0.033402164,0.047207136,0.035976797,0.03426555,0.059605196,0.01619047,-0.022008426,0.007157391,-0.02420037,-0.025088213,-0.027191252,-0.035937566,0.0021598218,-0.028637255,-0.06030737,0.01516654,-0.10017709,0.07025548,0.0022062338,-0.006463822,-0.05160831,0.012718041,-0.06468143,0.02030782,0.03845614,0.044061124,-0.1299356,0.00072572305,-0.0564263,-0.029395234,-0.031762842,-0.019007972,0.05966902,-0.027477894,-0.056247357,-0.008848936,-0.066563495,0.071021706,-0.047182538,-0.017999863,0.02981342,-0.011238881,0.002319766,-0.0006183144,0.0337282,0.03765794,0.039309427,-0.00526115,-0.024257533,0.007411815,0.0749873,0.055441264,0.037664995,-0.017872365,0.0053038783,0.05278096,-0.02319265,0.09227961,0.014939135,0.06496247,0.035155497,0.03289143,-0.08086853,0.08405748,-0.06005095,-0.017540473,-0.052554417,-0.0381711,-0.05548678,-0.0738358,0.03714711,0.03685128,0.033618324,-0.076461226,0.036300804,-0.0073287697,0.0041316017,0.03863291,-0.02566244,0.11625336,0.058810737,-0.009080888,0.012439637,-0.030648228,-0.017009398,0.043585245,0.037252255,0.044405185,-0.05092112,-0.023058074,0.0018640858,-0.054289002,-0.006787284,-0.0030741303,0.090720646,-0.030235758,-0.008216661,0.011743819,0.0832551,-0.07190251,-0.05704524,-0.019245535,0.022849044,-0.007551548,0.072431654,0.061149836,-0.03761228,-0.05714379,-0.034249365,0.02768797,0.003399714,-0.0024468477,0.08086435,0.041944597,-0.014130283,0.07664583,-0.033082224,0.0012252263,0.07191297,-0.0030420877,0.06911631,0.014574502,-0.010322158,-0.15452275,2.7076765e-33,0.06706673,0.006945699,0.051666636,0.06437184,-0.06889506,0.017677346,-0.083176225,-0.003796121,-0.0849912,-0.037275556,-0.0329338,-0.027104724,0.04583139,0.07422466,-0.016979748,-0.09825766,0.006137052,-0.034371823,0.011155116,-0.02064781,0.01462441,-0.022076013,-0.058295883,-0.010112053,-0.021290863,0.04756949,-0.0029851801,0.080998465,0.018019777,0.017869728,-0.057433736,-0.044727683,-0.10435649,0.03329868,0.023713773,-0.019499738,0.013227797,0.020135988,0.009579784,0.053970847,0.09365362,0.023832165,-0.019258102,-0.05410978,0.11961075,-0.07731333,-0.059855253,0.10726772,0.064945795,-0.0034094998,0.06562581,-0.051891144,0.07553403,-0.06611474,-0.059678942,0.07003921,-0.0044028466,-0.007858716,0.033266943,0.028630262,0.013097768,-0.009080054,-0.05143689,0.04955058,0.025994375,0.07410053,-0.032629784,-0.088826306,-0.062299643,0.09782415,-0.06934336,-0.05940332,0.14330208,0.020271165,-0.012077555,-0.015951749,-0.12488568,0.0018000314,0.030338151,0.03940127,-0.031025393,-0.023687419,-0.09728684,0.011819182,0.004510888,-0.071251616,-0.049553283,-0.0939352,-0.044644766,0.04809535,0.06033032,-0.04189202,-0.04982077,0.06525084,0.03653031,-4.5274808e-33,0.10583733,-0.042306848,0.08727293,-0.00962979,0.051988885,0.03812385,0.08011432,-0.033522826,0.00865802,0.02410153,0.10559703,-0.036348432,0.033281367,0.008686879,0.02781962,-0.025929889,0.0026197534,0.045499414,0.033465672,-0.025579784,-0.0064250166,-0.080764905,0.009747986,-0.032490194,-0.014738127,0.003346692,0.00067670847,0.06438973,0.039374284,-0.018917127,-0.12210883,-0.034158107,-0.118043825,0.03348368,-0.093952976,0.039926164,-0.062295634,-0.025614642,0.08865625,-0.055675946,0.040974833,-0.011082083,-0.059052177,0.07150563,0.061329294,0.098160036,-0.03237144,-0.002772319,-0.106204405,-0.04969876,0.05797236,0.061637096,-0.039680887,0.030159427,-0.061194237,0.13258915,0.05720885,-0.014179692,0.04152266,0.030560357,0.024929667,0.05508287,0.02161622,0.058614813,-0.06537726,0.017106099,0.025653578,0.09607396,-0.01663299,-0.020751277,0.07598053,-0.058499772,0.02828266,-0.03797112,0.02593445,0.022697303,-0.027920136,-0.04469217,0.01595355,-0.074719764,-0.029557172,-0.02357145,-0.051711388,-0.058191355,0.02162687,-0.03655274,0.002665194,0.111126475,0.040982433,0.028874466,-0.084398955,-0.012631406,-0.07205285,0.01124193,0.04572195,-4.1617838e-08,0.0013273861,-0.059268516,0.06731968,-0.032025848,0.01577559,0.04046459,-0.0091689825,0.03519972,-0.030306878,-0.015497329,-0.07238277,-0.0053060167,-0.00690566,-0.043585535,0.051051445,0.074406125,0.016216924,0.042815905,0.00078921963,-0.017812798,-0.04439405,-0.03351193,-0.035040922,0.00944722,-0.042045765,-0.04965588,0.0074827317,0.08461345,-0.036283255,-0.04166289,0.0011096905,0.037776746,-0.028381495,-0.039091706,-0.08244621,0.007115492,-0.04978322,-0.07044228,-0.034518544,-0.043188073,-0.008565523,-6.9541675e-05,-0.03514242,-0.011414791,-0.0007926321,0.05724639,0.05688988,0.072488725,-0.05774576,-0.007662476,-0.01030226,-0.08593117,-0.03644009,-0.07550713,-0.059392318,0.04368099,-0.026019646,-0.095707715,0.03201484,-0.05933041,-0.006084869,0.043806825,0.05775438,-0.050028186 +2.3.2.24,"The enzyme transfers a single ubiquitin directly from an ubiquitinated E1 ubiquitin-activating enzyme to itself, and on to a lysine residue of the acceptor protein without involvement of E3 ubiquitin transferases (cf. EC 2.3.2.26, EC 2.3.2.27). It forms a labile ubiquitin adduct in the presence of E1, ubiquitin, and Mg2+-ATP and catalyses the conjugation of ubiquitin to protein substrates, independently of E3. This transfer has only been observed with small proteins. In vitro a transfer to small acceptors (e.g. L-lysine, N-acetyl-L-lysine methyl ester) has been observed [1].",384,1.0,-0.052824132,-0.06033655,-0.015881345,0.053966932,0.07253679,0.020407965,0.047756918,-0.020834504,0.023677148,-0.032413673,0.021605292,-0.03054183,0.022076672,-0.0128204385,-0.017460216,-0.0069544497,-0.03948499,-0.04983762,-0.016372554,-0.058609057,0.07388823,-0.001275825,-0.05432126,-0.023980675,0.026322475,-0.06494085,0.023950608,-0.035997614,0.0011142057,-0.14441106,-0.019941067,-0.088579945,-0.010410311,-0.0753748,-0.00774456,0.086155444,-0.08019204,-0.018910132,-0.032365136,-0.045586884,0.10494396,-0.058582414,0.034844935,0.03186282,-0.05126896,-0.025230223,-0.006508974,-0.02577936,0.08393203,0.049035832,-0.018460536,0.023960268,0.020153672,0.07263671,0.03334964,-0.023453131,-0.066288486,0.033781957,0.016440786,0.023626244,-0.018562432,0.084697045,0.050470214,-0.031353522,0.038873777,-0.0739557,-0.0061388672,-0.047436234,0.025974968,-0.02507601,-0.011203698,-0.018160367,-0.07023804,0.034598324,-0.0066769863,0.078833036,-0.07953783,0.11534532,-0.034816954,0.04383767,0.002098885,-0.054877054,0.08342804,0.013118096,-0.0027964213,-0.006827978,-0.047667027,-0.00877889,0.03726281,0.038834665,0.06490957,-0.031925753,-0.032779038,0.050120424,-0.011895318,-0.029032173,0.016460968,0.033522237,-0.06852312,0.030830385,0.033052925,0.06817452,0.012683249,-0.040566903,-0.008477237,0.04408506,0.04600308,0.016392086,0.060852323,-0.04111681,-0.0583629,-0.008692668,0.020324526,-0.012687987,0.0223645,0.0667985,-0.02283138,-0.10734215,0.011069869,-0.033446334,-0.017898837,0.078288615,0.0661296,0.054076064,0.012227976,-0.041818388,-0.083496734,3.5148776e-33,0.055980194,0.004341919,0.0116739925,0.05416737,-0.10367451,0.033100292,-0.08407899,0.022080105,-0.02423474,-0.08508144,-0.029277511,-0.030090114,0.061094016,0.064212374,-0.016638547,-0.03892156,0.024447218,-0.060769852,0.13683395,2.7229578e-05,-0.040329326,-0.074799806,-0.06929563,0.022845922,-0.06183179,-0.0024667145,-0.0192572,0.038479276,0.031672683,0.003673299,0.00019553235,-0.05713106,-0.07606342,0.041103844,-0.04223871,0.0016110834,0.031111963,-0.009323118,0.01894916,0.00065632607,0.02304402,-0.016242195,-0.098243244,-0.051297,0.12035055,-0.03553422,-0.05585662,0.05682482,-0.054658055,-0.0007275685,0.10142534,-0.058644384,0.09949843,-0.12545021,-0.11277204,0.08098334,0.020380264,0.04483275,0.019311335,0.020201461,-0.01586296,0.018477771,-0.031111822,0.046808448,0.010077298,0.10062719,-0.042102043,-0.030596167,-0.052073825,-0.00059651164,-0.08402149,-0.07628044,0.06682331,0.017661473,0.025575204,-0.031664412,-0.13733886,0.020065717,0.06148481,0.052875236,-0.005261838,-0.039494865,-0.09195304,0.023721024,-0.02522644,-0.0027565,-0.009585902,-0.079491,0.008073129,0.045643,0.09850876,-0.022992294,-0.022230497,0.08771174,0.044806905,-5.1626742e-33,0.11702345,-0.040702138,0.101391636,0.014808829,0.0658678,0.045130305,0.11707508,0.034885023,0.041324638,-0.020707665,0.1014022,-0.064305134,0.020170448,-0.078212544,-0.009268601,-0.013599366,-0.046988003,0.062338956,0.0395829,0.03354571,-0.0003045425,-0.033732403,0.01704403,-0.03923832,-0.0230011,0.08641257,-0.03695658,0.071019,0.0342911,0.017556801,-0.04153976,0.005547826,-0.042601522,0.01220888,-0.060168613,0.02909334,-0.015049547,-0.018351227,0.060241465,-0.03516477,0.034418263,-0.021401294,-0.018449452,0.024069007,0.071538165,0.0962909,-0.060360845,-0.038616367,-0.085156776,-0.056999616,0.0072665955,0.06837644,-0.09489666,-0.0003154246,-0.05107519,0.117267594,0.10580199,0.037910137,0.07835606,0.03001435,-0.05029576,0.022891972,0.02591444,-0.0027394462,-0.03101231,0.023158126,0.0364768,0.09597674,0.028757714,-0.022931755,0.08260536,-0.049105916,0.10027057,-0.022294749,0.09093234,0.057889607,-0.01726231,-0.035940897,-0.03049246,-0.060679603,-0.053999476,-0.029154696,-0.029889826,-0.06473635,0.04533211,-0.0078515345,0.023818621,0.04591926,0.017951868,0.014455116,-0.055663615,-0.040083293,-0.021087052,-0.013250733,0.08451293,-4.67134e-08,0.026093237,-0.034332935,0.017541772,-0.022530423,0.022597231,0.06302214,-0.037040114,0.027027942,-0.05163942,-0.009203113,-0.051188,-0.015866064,-0.051213663,-0.008134152,0.03420378,0.0037460756,0.01962681,0.040032584,0.012976349,-0.03292203,-0.036156923,0.0067072557,-0.024128392,0.007904647,0.007407369,-0.05819231,-0.007745851,0.03854162,-0.014165445,-0.06652213,0.014763416,0.045992315,-0.015214835,-0.04545776,-0.04003092,0.0068284594,-0.030156653,-0.08794644,-0.011847346,-0.002692861,-0.050828867,0.015174553,-0.05096421,-0.041156113,0.026707543,0.053580336,0.036306262,0.06239718,-0.066806376,-0.022996508,0.035488114,-0.10382625,-0.04189992,-0.077496715,-0.013115324,0.041979905,-0.05539381,-0.074740574,0.02752421,-0.1283911,-0.03524515,-0.024870088,0.047308426,-0.05525198 +2.3.2.25,The enzyme ubiquitinylates the N-terminus of the acceptor protein. It is not reactive towards free lysine.,384,0.99999994,-0.059217088,-0.09274215,-0.07416804,0.03300472,0.11499153,0.046826288,-0.020872405,0.011630673,0.03776485,-0.010495151,0.05252561,-0.018571258,-0.03379621,0.05083213,0.0044013713,0.05424529,-0.0777311,-0.08062589,0.0066302433,-0.025441376,0.027478946,0.07600097,-0.045334972,-0.014137491,0.013901511,-0.09464158,0.059550103,-0.041562665,0.06237792,-0.07759197,0.0026365072,-0.05519824,0.010496093,-0.034278855,0.004165519,0.034182988,-0.06463042,-0.043228712,-0.010661317,-0.0013851239,0.011590401,-0.034823306,0.0027035854,-0.0073853787,-0.015522542,0.015450881,0.022523642,0.020452617,0.053189028,0.070979856,0.002303848,0.014350506,-0.007580987,0.054955103,-0.041244946,0.01477144,-0.120982945,0.029603576,-0.0018459933,-0.017567689,-0.02715186,0.06245544,0.008565232,-0.009854635,0.09608925,-0.07329691,-0.011262874,-0.019374557,0.04701216,-0.059464827,0.009020024,-0.059682347,0.03533557,0.0057874355,0.0488162,0.018756652,-0.044883337,0.06108031,0.014168622,0.045120124,-0.02563982,-0.04773714,0.051448017,0.121192545,0.015622353,-0.01973464,-0.07971521,0.049421623,0.010083223,0.002149355,0.026028719,-0.037006844,0.005422779,0.022535693,-0.020385303,-0.038894117,0.0545934,0.016329814,-0.07397274,0.019150177,-0.0060600876,0.048323862,-0.057050064,-0.0054085474,-0.042162847,0.0060705077,0.05465872,-0.0072044544,-0.019334462,-0.052266587,0.013371017,-0.022861179,0.12147511,0.052935608,0.010052242,0.018858107,-0.013181364,-0.10273243,-0.018707613,-0.04911808,-0.0025927708,0.039704166,0.02900813,0.10395629,-0.062517904,0.023212537,-0.09409333,-1.3096313e-33,0.042964473,0.026573423,0.036554277,-0.04960737,-0.06751705,0.021011455,-0.0721509,-0.0019441885,0.0140640745,-0.0522607,-0.025843238,-0.014770817,0.11894632,0.045877207,-0.04146619,-0.054825775,-0.0061907256,-0.02481683,0.08118477,0.016619882,0.0014252735,-0.0129387695,-0.037144493,0.03908008,-0.04832109,0.0059107062,-0.021236949,0.063766696,-0.005969088,-0.0050976607,-0.06529758,-0.07326067,-0.009706236,0.03927066,-0.018897573,-0.024707437,0.007946824,-0.03406933,-0.01116959,-0.032770444,0.016089268,0.02588187,-0.07933003,0.013725466,0.105041884,-0.035838075,-0.093923464,0.015000464,-0.082228154,0.0023188589,0.099958465,-0.04365733,0.018042509,-0.12751119,-0.07782606,0.03429271,-0.0263184,0.06469186,-0.016298605,0.07138094,0.029372005,0.015379686,-0.027519917,0.04621711,-0.029101113,0.04609491,-0.02006288,-0.09059103,-0.025738636,0.046128534,-0.06921803,-0.015636299,0.14138705,0.06333682,0.020576783,-0.04079736,-0.10519202,0.077592745,0.056313016,-0.007728782,-0.009996367,-0.051249392,-0.08214346,0.06988436,-0.0016980107,-0.048623312,0.051731147,-0.07198778,0.013713378,0.015705936,0.03574584,-0.07614095,0.0029863315,0.089230396,0.06638397,-3.6101707e-34,0.08383406,-0.08447494,0.048294246,-0.0020297163,0.06270737,0.05710267,0.097611584,-0.006962501,0.1259006,-0.039920565,0.13421158,-0.021976752,-0.028209822,0.037919704,0.05974813,0.045546416,-0.03458756,0.06575871,0.0060608746,0.03290534,-0.024786578,-0.016518516,0.03206323,-0.05729507,0.027322805,0.043285664,-0.057165463,0.024602134,0.012641843,0.044364605,-0.0553494,0.0057213497,-0.08749608,-0.08256493,-0.028992048,0.035727683,-0.065927096,-0.018279891,0.035002373,-0.072092965,0.05153754,-0.039899446,-0.049036473,0.0736099,0.012863183,0.05594495,-0.028670175,-0.062144153,-0.04779054,-0.06884635,0.027112545,-0.003923462,0.028265284,0.006685808,0.004877597,0.11550235,0.057304915,0.044607773,0.009373184,0.028102469,-0.050079726,-0.009644465,-0.030764623,0.06327558,0.022952251,-0.016353752,-0.018542212,0.071920216,0.0541037,-0.07080912,0.14059523,0.006664005,0.1150819,0.044178918,0.033140853,0.043131527,-0.0707911,-0.10233015,0.003005578,-0.07418523,-0.10219643,0.012486808,-0.027326355,-0.035182893,0.010911056,-0.022145018,0.016062794,0.03536479,0.042432863,0.043593213,0.0137896985,-0.045760486,0.012756548,-0.0053345347,0.105920866,-2.7398137e-08,0.073873706,-0.069441564,0.012744969,-0.030241076,-0.024409052,0.08098737,0.0021728585,-0.03408226,-0.07522532,0.049151573,0.026317948,0.018624749,-0.042784844,-0.020309472,0.011464742,0.032026175,-0.017454872,0.043896362,-0.026563888,-0.010528708,-0.04391047,0.04521765,-0.017241,-0.012608978,-0.025317434,-0.040818814,0.009490466,0.00035278543,-0.02681564,-0.08039077,0.0461435,0.00149408,-0.01912966,-0.08045212,-0.060341876,0.04941867,0.033180997,-0.04312597,0.029326053,0.035711087,-0.022107609,0.04813236,-0.060590774,-0.039206512,0.022482483,0.04171127,-0.0001763095,0.035484076,-0.035803095,0.015688648,0.019645019,-0.08634683,-0.01431189,-0.092698336,-0.017631073,0.0067924433,-0.073615916,-0.030822407,0.063159786,-0.093198605,-0.05089061,0.045856383,0.1428535,-0.06977859 +2.3.2.26,"In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27, RING-type E3 ubiquitin transferase and EC 2.3.2.31, RBR-type E3 ubiquitin transferase.",384,1.0,-0.072108656,-0.032682054,-0.07626445,0.007978282,0.101106346,0.03118278,-0.012056568,0.053065144,0.03720153,-0.070715815,0.052774422,-0.028013635,-0.00037856633,-0.006851198,-0.049044833,-0.046952337,-0.052155234,-0.04999904,-0.021550985,-0.06607594,0.046377502,0.038906306,-0.038256824,-0.010574736,0.017058453,-0.039288215,0.04782578,-0.016410904,0.019432062,-0.12329808,-0.039600447,-0.07828147,0.009224917,-0.06486394,0.0118381,0.10323383,-0.06669978,-0.07526265,-0.032551493,-0.043522228,0.09726872,-0.03436901,0.033634037,0.043687247,-0.037786584,0.004244513,-0.0043615163,0.021074004,0.06985267,0.04176855,-0.005712194,7.450545e-05,0.007884818,0.061837547,-0.016831717,0.0059109563,-0.04614319,0.031500347,-0.0049424055,0.03125855,0.006301363,0.06629218,0.028222278,-0.033222675,0.030766588,-0.07009816,0.07574937,-0.039570723,-0.017413894,-0.02740629,-0.018764824,-0.03219457,-0.09945718,0.032829583,0.018222013,0.0682941,-0.104921676,0.082689285,-0.012460629,-0.004838797,-0.002161443,-0.053735144,0.092020854,0.027641006,-0.016062273,0.017238827,-0.056161683,-0.027503213,0.009232772,0.032694664,0.06522568,-0.028373327,-0.037244096,0.028969558,-0.03131164,-0.012199854,0.030153027,0.09820863,-0.030840086,0.01871635,0.027578253,0.0793193,-0.027666112,-0.045138955,-0.014288966,0.010919582,0.029983146,0.07475741,0.0641919,-0.008490745,-0.024940342,0.0010046967,0.049368624,-0.038374122,-0.00080701447,0.092778884,-0.0030973095,-0.039381906,0.015175692,-0.0022208677,0.02472499,0.07555544,0.03263394,0.06691628,-1.6196196e-07,-0.06754363,-0.12477515,3.1135587e-33,0.10301928,0.043436095,0.051935054,0.044625573,-0.09427734,0.026440537,-0.12717143,0.024549102,-0.04280495,-0.03781552,-0.033852316,-0.0349423,0.06123208,0.019319355,-0.01986881,-0.079909645,-0.0041180192,-0.05077612,0.073600054,0.011201864,0.03212718,-0.031371105,-0.05893615,0.018603848,-0.017308217,0.032784317,0.0073548304,0.053821914,0.037562247,0.016445115,-0.039854154,-0.041144304,-0.097234674,0.025459956,-0.008695378,-0.019966675,0.025974585,-0.027271641,0.027419455,0.033650458,0.08231791,0.0064228363,-0.045543,-0.03854977,0.13551079,-0.060992572,0.0032092861,0.08979555,-0.008179461,0.006696637,0.05034895,-0.07624919,0.07589939,-0.06909453,-0.073945135,0.028176911,0.024737624,0.047623873,-0.019007247,0.055339385,0.035926796,0.056565218,-0.046225943,0.04625925,0.00060441316,0.067761384,-0.099377565,-0.055732068,-0.053659376,0.03842484,-0.08130325,-0.048345067,0.1113758,0.03178638,0.0062948125,-0.06346204,-0.15697622,0.02050378,0.06281454,-0.008923895,-0.06623998,-0.0012553071,-0.09290138,0.010310005,-0.061506,-0.02657697,0.020667212,-0.06319758,-0.0035237041,0.040283598,0.108281136,-0.03855486,0.001845468,0.061413154,0.047714822,-4.2002746e-33,0.13325195,-0.049976535,0.05806849,0.0022293192,0.06806834,0.018141668,0.0637592,0.027570374,0.05416431,-0.071640804,0.11670911,-0.041280814,0.015748132,-0.045147505,0.036326814,-0.01630601,-0.03137079,0.053939883,-0.00606072,-0.009088338,-0.002689674,-0.088673145,0.0087229,-0.0143275615,-0.026465489,0.048071932,-0.015707176,0.07507973,0.014653195,0.03538791,-0.07810448,-0.020276692,-0.09484248,0.018445754,-0.07900893,0.0137662,-0.04599066,-0.0042531365,0.082812764,-0.07727347,0.02978041,-0.023439161,-0.021895206,0.041582793,0.072375394,0.1114053,-0.032401025,0.0014880938,-0.061254986,-0.063144594,0.024730884,0.012439426,-0.070050165,0.039920818,-0.064345226,0.101296805,0.08257588,0.015182197,0.05161463,0.044641558,-0.023032183,0.040834296,0.014686455,0.03756271,-0.027994696,-0.025773257,0.025507776,0.07537281,0.06962452,0.006147658,0.05457042,-0.06156252,0.066363,0.004130886,0.069192246,0.018743768,-0.015905479,-0.018443162,-0.013080208,-0.081716135,-0.049932346,-0.039722215,-0.01577859,-0.032995444,0.049583547,-0.025412763,0.016006313,0.05682763,0.011927415,0.016146697,-0.08095227,-0.007644695,-0.0044827936,0.050187245,0.09833385,-4.7608204e-08,0.04076712,-0.058282558,-0.016803779,-0.035796005,0.051194787,0.06830069,-0.04257328,0.02202923,-0.031577174,0.0020563644,-0.063685544,0.01165051,-0.053724326,-0.07109971,0.05260682,0.06846523,0.026325608,0.057637386,0.012369348,-0.023375832,-0.04818282,-0.021917874,-0.038076233,-0.033194143,-0.051657803,-0.032915965,-0.0013645643,0.0722229,-0.010671525,-0.006788295,0.008589021,0.03149694,0.010494636,-0.04605652,-0.06085651,0.021171529,-0.029046247,-0.0555132,0.017892852,-0.020088028,-0.002023754,0.0012090743,-0.1201014,-0.023066178,0.07050278,0.0133660585,0.049196124,0.08707049,-0.060634345,-0.03784001,-0.029782498,-0.06690144,-0.025867173,-0.047918055,-0.018504674,0.03291812,-0.05445954,-0.09424393,0.051160526,-0.0843008,-0.041772522,-0.018634154,0.06701008,-0.024056792 +2.3.2.27,"RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase.",384,0.99999994,-0.11241577,-0.05995598,-0.07409532,-0.02558028,0.13689029,0.012085761,-0.008946347,0.04072553,0.047501825,-0.084467225,-0.019907147,-0.053813998,0.03539269,0.013438934,0.013460941,-0.03718586,-0.04315015,0.029456455,-0.033138186,-0.10763941,0.06752457,0.053176116,0.018044565,-0.03487099,-0.017650446,-0.02711059,0.034772325,-0.017225254,-0.0015584629,-0.113417685,-0.008167095,-0.050042395,-0.031560514,-0.07600626,-0.0025246155,0.10628778,-0.095913135,-0.054639306,-0.076350905,-0.08190954,0.110908166,0.008162618,0.052742563,-0.023917796,-0.058944963,-0.008588715,-0.0029157163,-0.0056156637,0.055045947,-0.014532605,0.020906512,-0.012741906,0.020840067,0.08788743,-0.001770673,0.05090279,-0.034270372,-0.014833571,-0.011844443,-0.0026872358,0.013592325,0.03980579,0.0498698,-0.028839512,0.002650197,-0.03901341,0.03649355,-0.0040076682,-0.010517756,-0.01460737,-0.011570078,0.020197095,-0.09587584,0.080099575,0.023373302,0.07766996,-0.042856,0.083242714,-0.02141732,-0.0011130937,-0.027801314,0.0011600812,0.12242617,0.012135079,0.019692976,0.012381393,-0.0728595,0.0025140715,-0.0022313774,0.03351717,0.05016369,-0.016435418,-0.05557806,0.023441581,0.0010874609,-0.02151942,0.02166802,0.03982567,-0.049140863,0.011045127,0.010778045,0.09381188,-0.024517128,-0.035499778,0.0110910805,0.019243106,0.04001607,0.07459573,-0.0011625503,-0.033746827,-0.045919664,-0.03456665,0.06589281,-0.06480638,-0.03308817,0.09342908,-0.056870658,-0.038364157,0.07025933,-0.007867864,0.024525022,0.060421344,0.004064435,0.023902414,-0.0037380045,-0.015150456,-0.10412889,6.180423e-33,0.034082755,0.0749342,0.003995625,0.023581041,-0.09233436,0.002068588,-0.13384187,0.028599078,-0.037073486,-0.03950195,-0.037397604,0.018528882,0.044612724,0.025567284,0.01780259,-0.07390655,-0.0069077364,-0.015664894,0.041426525,0.017155187,0.017173227,-0.01653774,-0.07377383,0.04138451,0.0054592285,0.026569521,0.051787782,0.06606055,0.061233774,0.012496485,-0.042143807,-0.0067810398,-0.023713455,0.009013286,0.017678538,0.0097412,-0.007071387,-0.023499452,0.064781055,0.05685229,0.09375775,-0.021768332,-0.07802863,-0.036808077,0.0682434,-0.06834959,0.00607945,0.047803305,-0.047352172,-0.0034793667,0.11251707,-0.08458382,0.059211228,-0.0921314,-0.056457736,-0.0048899725,0.0094512,0.0077863117,0.026750956,0.0033192735,-0.015963648,-0.0161391,-0.033979047,0.07584188,0.0060691354,0.10148571,-0.09894752,-0.0535765,-0.04192108,0.046783995,-0.06603425,-0.01439519,0.07774151,0.01719337,0.044356074,-0.05858953,-0.1440161,-0.039962318,0.071802706,0.04876929,-0.020202367,0.00087532814,-0.096824676,-0.019932639,-0.04393656,-0.081540816,-0.02474456,-0.019977918,0.035460558,-0.007005555,0.119676,-0.04159837,0.015684405,0.10467908,0.024884503,-5.5506535e-33,0.120135576,-0.058542635,0.08755065,0.010221569,0.02661184,0.052834745,0.08909388,-0.015670987,0.07278257,-0.06458151,0.082289845,-0.066657685,5.9146158e-05,-0.057661384,0.013264937,-0.034183383,-0.02681252,0.030942861,0.008382675,-0.017468112,0.012932608,-0.053535473,-0.02466913,0.0040357984,-0.06758066,0.067511104,-0.06812161,0.060070265,0.024088554,0.033467203,-0.049917564,-0.058184613,-0.07627137,0.06998234,-0.07314543,0.042252883,0.042196818,-0.0058026747,0.06111207,-0.06367953,0.06844471,-0.012744806,-0.0039136116,0.06338652,0.03864164,0.10620332,-0.03843945,-0.017039012,-0.027496384,-0.060858753,0.02662231,0.042166207,-0.07870968,-0.013487023,-0.04747887,0.07653738,0.11922058,-0.042006604,0.005075545,0.025516663,-0.02241492,0.014641044,0.05503744,0.041659333,-0.03510008,0.022658566,0.005778316,0.09867829,0.08650849,0.01749855,0.012703366,-0.025791157,0.07045876,-0.042224687,0.04702722,0.014239428,-0.026707668,-0.01631526,-0.012505149,-0.046724994,-0.025172194,-0.050732397,0.0058107655,-0.065046564,0.049301192,0.0012732216,0.008841126,0.08036365,0.013830843,0.004442795,-0.06742678,-0.022264214,0.009726769,0.070737936,0.110495955,-5.0709026e-08,0.039772194,-0.018522752,0.012141541,-0.029022252,-0.004674789,0.027317002,-0.024217032,0.026154993,0.024419952,-0.030594865,-0.073114045,0.004339194,-0.051467083,-0.090926334,0.063800886,0.10512908,0.028653374,0.024999827,0.035845157,-0.060853917,0.020909078,0.004775047,-0.024412725,0.00653295,-0.04330229,-0.030816484,0.007231735,0.08930996,0.02283932,-0.036164597,-0.038541835,-0.0054910565,-0.035782605,-0.009642035,-0.032033093,0.0013577827,0.015291854,-0.09203489,-0.001285783,-0.012464492,0.023247339,0.032139253,-0.121302724,-0.055425398,0.040510364,0.0083579235,0.06491158,0.067565076,-0.07860513,-0.009488497,-0.027457248,-0.040635373,-0.024956996,-0.032209225,-0.051183652,0.05792171,-0.055893265,-0.096009016,-0.0035224846,-0.06416844,-0.040376052,-0.026685093,0.085887656,-0.016983634 +2.3.2.28,"The enzyme, characterized from the bacterium Pseudomonas syringae, is involved in the biosynthesis of the toxin coronatine. ",384,1.0,-0.05031992,-0.016441898,-0.11039472,0.06685454,-0.0017780268,0.018335259,-0.06906725,0.1003509,0.03919395,-0.06074985,0.029597383,-0.085279554,-0.034077063,0.08172043,-0.05121648,-0.018134566,-0.084539786,-0.016663438,0.05874259,0.035677023,0.07393429,0.10687017,-0.06603978,0.07609798,0.047377896,0.041696936,0.022978012,-0.030833641,0.0010626917,-0.000603924,-0.026645815,-0.107118554,0.051277805,-0.07252757,0.09975213,0.05163334,0.00097576145,0.0017314531,0.14806919,-0.006977412,0.020225598,-0.020266563,-0.019971812,-0.07438658,0.06297803,0.046482928,0.006759758,0.025931917,0.056511465,-0.003652569,-0.065302506,-0.06357919,-0.025953235,0.015379086,-0.0007562841,0.045021646,0.024496047,-0.06663297,-0.0058137714,0.012123056,0.023652088,-0.0389356,-0.017623464,0.07726602,-0.03112621,-0.09055258,0.031203821,0.010354115,0.054541633,-0.04426298,-0.013644753,-0.037491206,-0.009383472,0.05741318,0.030670075,-0.016722322,-0.0071532335,0.013749258,-0.013751879,-0.054039683,0.085742526,0.019449722,0.013234387,0.117998876,0.06111294,-0.0067621823,0.05802738,0.0024749078,0.06189514,-0.0033169629,0.0386833,-0.0150402775,-0.016842974,-0.021686338,-0.08672338,0.016648913,0.023012005,0.053080726,0.04543577,-0.03128201,0.030579476,0.03963191,-0.057035428,-0.03553639,0.067697495,-0.022075955,-0.03967672,0.04643947,0.054416504,-0.06247546,0.004487722,-0.006618613,-0.02729818,-0.05210075,0.031016883,0.12638207,0.049779072,-0.07740536,-0.09438436,0.011263729,0.024149235,-0.07172422,0.019764816,0.071533024,-0.011078804,0.017478593,-0.11285903,-1.4372783e-33,0.043835342,0.056225553,0.012381106,-0.019442827,0.014598402,-0.025527991,-0.08443871,-0.021111274,-0.035285912,-0.035713755,-0.057085037,-0.0867038,0.025914827,0.027446039,0.030340457,-0.023980953,-0.038510114,-0.037060793,0.00817452,-0.042559624,0.0053154435,0.030590232,-0.026703216,0.038795456,0.013619461,0.043530285,0.032937992,-0.016116288,-0.017314365,-0.0135169,0.013163896,-0.07773602,-0.019320201,-0.014868822,0.07653509,-0.036084343,-0.02356237,-0.057425044,0.0034406916,0.09754581,0.035746522,0.058201637,-0.05655572,0.01091899,0.065524496,-0.042644493,-0.04390031,0.11579015,0.010235731,0.062299307,0.0060442486,-0.005068841,0.13579087,-0.010694576,-0.048603117,-0.0023348872,-0.01018505,-0.027487595,-0.00952813,0.016033197,0.033898704,0.0074430853,-0.0683792,0.06113636,-0.082152,0.03828489,-0.013025933,-0.012668479,0.04739215,0.049931478,-0.092791945,0.029986847,-0.060002573,0.0037262358,0.007910375,-0.04447367,-0.089978926,0.07109778,-0.037106838,-0.047980357,-0.060298253,-0.04491044,0.02219783,0.011164878,-0.08017074,-0.0017657116,0.029257022,-0.02667962,-0.044295657,0.006683752,0.055836078,0.014178665,-0.031210668,0.05780232,-0.059535585,-3.1099055e-35,0.04381324,-0.08429157,0.03277617,-0.08435156,-0.028174048,0.07460135,-0.05650648,0.040612813,0.05090194,-0.034363817,-0.0014375062,0.016174532,0.044163506,-0.025649674,9.735843e-05,0.07706114,-0.028991317,0.019998623,-0.051235896,-0.008721277,0.02675864,0.060365513,-0.015173564,-0.036008038,0.059141885,0.061954755,-0.060349043,0.034567717,0.12486598,0.05092471,0.006810549,0.06509516,-0.02397108,-0.01901133,-0.041676342,0.055155467,0.02073384,0.06750184,0.05150888,-0.0033907897,0.024228873,0.057044815,-0.04653815,0.03741746,0.0090031205,0.072109506,-0.011450495,-0.0032689946,-0.05349416,-0.09235978,0.025809139,-0.041678548,0.042702563,0.09252262,-0.012039892,-0.044556268,-0.019077055,-0.0025417097,-0.04017478,-0.08419494,-0.030037096,-0.08189019,0.026052466,-0.070463695,0.038022608,0.019128505,-0.021746611,0.00019691559,0.0009945917,-0.08174406,0.08664354,0.021684775,-0.064348646,0.0127172405,-0.1123995,0.022124697,-0.10014923,-0.08657808,-0.0072399643,0.0105679985,-0.030420715,0.056057073,0.05269667,-0.058513377,-0.04976301,-0.056833353,0.03317172,0.070884414,-0.026327528,0.035853483,-0.02610593,0.0012133102,0.0070081237,0.043044586,0.01499191,-2.5483192e-08,0.05929518,-0.06984201,-0.0011888793,-0.0148267755,0.0058402754,0.061768547,0.0036827517,0.01847067,0.02530963,-0.019418651,-0.045871515,0.040821027,0.0396288,-0.030735208,-0.023236515,0.04005963,-0.06437741,0.002030181,-0.021265076,0.010986259,-0.03226837,-0.004759864,-0.07676965,0.015548672,0.016915634,-0.05837629,0.034614198,0.0062517724,-0.018855497,-0.07529504,-0.032803323,0.016933193,0.036189735,-0.035008967,-0.098521486,0.0785022,-0.009739815,-0.08470908,-0.014064695,-0.026929813,0.048719898,-0.05873918,-0.09940764,0.026151229,0.012400393,-0.029728416,-0.004435758,-0.032274548,0.029665478,-0.006015105,0.09613391,-0.0024499523,0.026436798,-0.039471067,-0.12652703,0.018428877,-0.0027009053,-0.05505501,-0.03844572,-0.02158022,0.048963543,0.02645134,0.25583982,0.020852825 +2.6.1.108," A pyridoxal 5'-phosphate protein. The enzyme, characterized from the archaebacterium Methanocaldococcus jannaschii, participates in the biosynthesis of the cofactor methanofuran. Requires pyridoxal 5'-phosphate.",384,0.99999994,-0.08178193,-0.047863565,-0.092701584,-0.061474644,0.057782415,0.024445139,-0.08124636,-0.005758391,0.04307952,-0.0036633094,-0.047616057,-0.05041585,-0.102104545,0.06605739,-0.055269845,0.040332153,-0.07457842,0.03629493,0.023766268,-0.03354724,0.13796096,0.08250677,0.0014432678,-0.019028995,0.0146307135,0.03266424,0.031187138,0.016371211,-0.0015075487,-0.036240164,0.015493267,0.003784253,0.012373838,-0.10992016,0.086062446,0.11754183,-0.033193566,-0.052336358,0.09263959,0.039382715,0.108571835,-0.016397182,0.0509964,0.007957408,-0.04416721,-0.005716127,0.033802047,0.045826383,0.08735651,-0.051415198,-0.12469535,-0.026845846,-0.07313124,-0.03543957,0.026678378,0.07393533,0.02063594,-0.07120644,-0.0033034347,-0.07015564,0.052788682,0.008379383,0.04202086,0.013519824,0.021630744,-0.05032869,-0.01733705,-0.10714395,0.057340465,-0.02168308,-0.067547336,0.0071983775,0.05183119,0.006697796,-0.061977208,0.041271266,-0.051523827,-0.02696163,0.013390404,-0.025252843,0.01412523,0.013130181,0.005226315,0.0223097,0.044731323,-0.00642636,0.011917694,-0.009293243,0.032463327,-0.043711495,-0.01960609,-0.03911712,0.02769064,-0.050139852,-0.061157215,-0.030595807,0.050871104,0.0021821037,-0.05109186,0.0065049888,0.0037755328,0.0050611584,0.005147457,-0.0506923,-0.10181664,-0.0415189,-0.025722034,0.07397658,0.0019605844,0.06729969,0.009071161,0.01853024,-0.003431565,-0.011636723,0.024950301,0.011944787,0.0038019118,-0.083716966,-0.05319983,0.033969864,-0.0030188314,-0.08926882,0.043864623,0.027884867,-0.055028178,0.00906137,-0.116335854,3.82493e-33,0.068627976,0.044981685,0.004810384,-0.015953058,0.019980775,-0.037238784,-0.07578925,-0.01825904,-0.03509096,-0.049918976,-0.02134817,0.0071393107,0.06677369,-0.00018209773,-0.099142514,0.011531319,-0.05022734,0.028259803,0.058082264,0.0024235975,0.021667687,0.102636136,-0.03460367,0.08973441,0.026270602,0.04000938,-0.027409792,-0.0038709526,-0.0053659673,0.014709531,0.03461167,-0.087078825,-0.099090606,-0.015665408,0.10796624,-0.05195453,-0.039660674,-0.077517994,-0.047872044,-0.019026339,-0.007538076,-0.030374212,-0.0016391336,0.015300279,0.031407796,-0.014764265,-0.01573245,0.086708605,0.013925091,0.02397817,0.030057842,-0.025941277,0.07396092,-0.0029365057,-0.12196757,-0.043812983,-0.021261752,-0.038328573,0.05969379,0.055783678,-0.006698381,0.0060473764,-0.04511179,0.05189452,-0.031753127,-0.02509677,0.042005956,-0.06079543,0.12521088,0.0903001,0.0012559136,0.0024488487,-0.02047117,0.11488853,-0.018785063,-0.04151833,0.0074109524,0.0063633216,-0.010377872,0.045007378,0.050425988,-0.03830902,-0.0039604865,-0.057381984,-0.04898851,0.013197087,-0.00052748836,-0.06292563,-0.020174757,0.016444083,0.0636392,-0.11864577,-0.027578214,0.08436814,-0.010030397,-4.2764404e-33,0.10110746,-0.11083248,0.0633238,-0.054579232,-0.080055274,0.041831672,0.055430193,-0.023991609,0.011721322,-0.038355093,0.09031386,0.00024255262,0.06545094,-0.0035845644,0.030312387,-0.014172254,0.04411378,0.031854354,0.062848635,0.04973983,0.07025259,0.0514977,-0.023061479,-0.02216555,0.06064354,0.062373325,-0.016897429,0.019119913,-0.06730934,0.0029354757,-0.014560287,0.04688533,-0.03926807,-0.10076223,-0.11626548,-0.019331587,-0.077646926,0.000912761,0.012139815,-0.019286064,0.06376799,0.09401908,0.013689496,0.020422097,-0.0030963034,-0.0043225028,-0.03605312,0.0035474638,0.013004024,-0.05496074,0.0066070016,-0.0048721763,-0.0067767887,-0.04674831,0.0076308576,0.053046603,0.0014793412,0.061206836,0.049535114,0.03689174,-0.033030644,-0.06266402,0.09087419,0.05595108,0.057024386,0.10205854,0.018545767,0.037059505,0.0423813,0.040994093,0.032800872,0.07005463,0.07705319,0.11697233,-0.054728348,-0.012680173,-0.06981565,0.06830274,0.020157227,0.019203879,-0.019015279,-0.05825951,0.019417275,-0.06577185,-0.007857724,-0.045242447,0.11798844,0.061348755,0.026849853,0.0328748,0.005977868,0.0031903186,-0.05499554,0.016630655,0.059851393,-3.543048e-08,0.03972245,-0.034976814,0.034041215,-0.06596369,-0.0058903596,0.020328099,0.047798607,-0.048368633,0.08787865,-0.019363344,0.048748493,0.0131429685,-0.0018162837,0.012505316,0.014015487,0.070152655,-0.082884364,-0.018904127,-0.00959468,-0.0245073,-0.0035515192,0.00978817,-0.07718781,0.048662756,0.05423993,-0.05755951,-0.010870025,0.0408434,-0.018497882,-0.031509552,-0.02402347,-0.0029236549,-0.0006558032,-0.0550429,-0.08449113,0.062359035,-0.046644293,-0.051075194,-0.04965651,-0.008638742,0.0008663784,0.0015019611,-0.02618166,-0.01622775,-0.017459422,0.030378638,-0.05630443,0.029798256,-0.054664623,-0.0447962,0.047371756,-0.025603704,-0.042314086,-0.062680125,-0.15001811,-0.0073280353,0.019915253,-0.034358654,-0.09127295,-0.031509727,0.036083993,-0.004980725,0.13088553,-0.039937854 +2.6.1.109,"The enzyme, characterized from the bacterium Shewanella oneidensis, forms 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate, an aminated form of Kdo found in lipopolysaccharides of members of the Shewanella genus. cf. EC 1.1.3.48, 3-deoxy-alpha-D-manno-octulosonate 8-oxidase.",384,0.99999994,-0.056318916,-0.064734645,-0.034623075,-0.020467363,-0.03778822,0.04613351,-0.01054974,0.034775585,0.016110964,0.08346595,0.048407312,-0.084566005,-0.084448345,0.02315329,-0.013049923,0.021930622,-0.061400708,-0.010817306,-0.0014041406,-0.02312869,0.11468352,0.067716144,0.022169635,0.0029744501,0.024655463,0.083997935,0.08422791,0.0012513078,-0.039050836,-0.052846555,-0.06277085,-0.053609055,0.09575485,-0.040277105,0.10146821,0.069921866,-0.0053160223,-0.07309821,0.08058015,-0.038323708,0.001383784,-0.0061956844,0.0746754,-0.073582925,-0.06954139,-0.011814256,0.048292644,0.08809783,0.10216223,-0.043690853,0.011252731,-0.091614425,-0.025458105,-0.0212229,0.031447347,0.011653158,-0.02364966,-0.010188211,-0.017986024,0.024528367,0.022305075,0.051812112,0.040821,0.056900293,0.0044159573,-0.040061526,0.0528102,-0.08415167,0.022989262,-0.04988938,0.028591065,-0.061574034,-0.0016763756,0.061312538,-0.028805466,0.023791919,0.09272943,-0.047035728,0.056124926,-0.03508238,0.025683131,-0.023997752,0.028847743,0.09173389,-0.034473356,-0.029606111,-0.041712675,0.0037059397,0.123254284,-0.016158866,0.009118459,-0.002394012,-0.026115013,-0.0877453,-0.036741648,-0.0074732634,0.008383141,0.06706525,0.04098885,-0.020998685,0.046160873,0.022328641,-0.03533057,-0.03487371,-0.031297736,0.019784741,0.006837583,-0.046571918,0.043449476,0.032532487,0.0207087,-0.013420086,-0.029545033,-0.0410799,-0.063575916,0.013439224,0.022338808,-0.07924146,-0.09411708,-0.0036556523,-0.050063312,-0.08583141,0.090744145,0.07490926,-0.045554228,0.01448189,-0.0830809,-8.372864e-34,0.0029111945,0.02125906,0.04632585,-0.06350916,0.06916307,-0.0640689,-0.015792307,0.036986608,-0.07180674,-0.018763624,-0.13427103,-0.04869215,0.019111227,0.018350732,0.021151109,0.04974898,-0.03565826,0.019771663,0.05464015,0.054822903,0.033409264,0.04477196,0.014083418,0.019713959,0.074312754,0.04706394,0.02994199,-0.01950233,0.049435265,0.0045211087,0.045236424,-0.08804045,-0.10882376,-0.046739828,-0.024373172,-0.022114418,-0.08877524,-0.0206787,0.009287104,0.044605188,-0.0038244128,0.020711292,-0.014881244,-0.052072696,0.019897591,0.006508437,-0.016006133,0.005658289,0.06050625,-0.0055764476,0.03249094,0.022928027,0.07673513,-0.025407398,-0.05385256,0.060423393,0.034590807,0.025046028,0.112237215,0.046016548,0.036290105,0.084995806,-0.050867114,0.022832263,0.014444677,0.036295056,0.02132563,-0.041948408,0.058048867,-0.008569387,-0.058746208,-0.035310183,-0.02282569,-0.03356563,0.010762076,-0.037919354,-0.08296397,0.0098218825,0.048880786,-0.014157724,0.07163698,-0.021420198,0.01028573,-0.03553133,-0.021647183,0.021482894,-0.026056485,-0.0030714856,-0.061925024,0.0382603,0.036009546,-0.072239235,-0.08684183,0.025062092,-0.05083374,-2.141759e-33,-0.0055901185,-0.09851324,0.006133139,-0.070590176,-0.004971775,0.043877624,0.013649383,0.084224604,0.06382285,-0.027393855,0.12033039,-0.029672101,0.0344571,-0.036428347,0.028817017,0.036209945,-0.06676149,0.095792264,-0.02094329,-0.03353218,-0.03279303,0.015104501,0.02972074,0.010370187,-0.0138283875,-0.040810406,-0.037477802,0.08523896,0.03637065,0.04396138,0.011046007,0.00052995683,-0.010671723,-0.044329025,-0.030435469,-0.0069147283,-0.056823958,-0.016475547,0.09553199,0.05095067,0.010798903,0.064713486,0.06584394,0.016557114,-0.045595825,0.049818676,-0.11159328,0.040964708,-0.016924595,-0.041969977,-0.00013199374,-0.009879789,-0.032527104,0.013369503,0.036437474,0.0526222,-0.006834115,0.044440743,-0.034389105,-0.033142045,-0.09578,-0.14110927,0.094940096,0.07035172,0.06255213,0.09447308,-0.063843496,-0.016271308,-0.013167992,-0.027066719,-0.013701236,-0.023106258,-0.025252264,0.040972304,0.022024712,0.0023233567,-0.08855315,-0.017186431,0.05336611,-0.018027136,0.014862291,-0.053725265,0.015312512,0.007893066,0.04855367,-0.08847733,0.096479796,0.09391974,0.02827296,0.06597021,0.0032857459,-0.012726718,-0.07064299,0.016042082,0.042667303,-3.9379763e-08,0.01997711,-0.10463114,0.11505479,-0.06403231,0.026674451,0.030887812,0.017241267,-0.012142821,0.10295698,-0.06544978,0.052120853,0.07966379,-0.025519254,0.014075168,-0.042336475,-0.037991874,-0.09835656,0.023798566,-0.022167202,0.015151042,-0.054242674,-0.003306189,-0.031681035,-0.059689645,0.03648937,0.009172308,-0.012626647,0.0024996132,-0.06898298,-0.011579253,-0.08158309,0.03766708,-0.05615192,-0.058379877,-0.08988733,-0.025288282,-0.026172556,-0.022635443,-0.067667015,0.017616658,0.032368086,-0.06503203,-0.040369045,0.00089407404,0.051656827,0.055790737,0.007903665,0.07993221,-0.034897164,-0.05151179,-0.020670261,0.013060962,-0.04248833,-0.08936241,-0.0984185,-0.04384991,-0.0523473,-0.038758077,-0.030382024,0.014051445,0.045862723,-0.0110687995,0.1611219,0.002258452 +2.7.1.189,The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.,384,1.0,-0.08197574,-0.08826789,-0.0004119165,-0.00032917113,0.056786448,0.010500812,-0.065540306,0.059818942,0.052951876,0.012712621,-0.030589828,-0.07187696,-0.046713423,0.08366318,-0.0652956,0.09222302,-0.06640537,-0.047468837,0.031817216,-0.09023387,0.057498906,0.070203096,-0.051789407,-0.023330139,-0.016815187,0.045712616,0.010533925,-0.034682147,-0.010507026,-0.052784126,0.031178603,-0.036502186,0.096090846,-0.07271254,0.094362244,0.026349168,-0.0089983195,-0.10501934,0.10604085,-0.03362762,0.061264068,0.0016483095,0.025595872,-0.044273794,0.03173833,0.035844952,0.01289737,0.04977834,0.104103826,0.031716015,-0.10058342,-0.007644083,0.01070917,0.015219313,0.06428546,0.12030193,-0.03312458,-0.018088697,0.026866117,-0.0061433045,0.07706873,-0.012847806,0.05040121,0.024619948,-0.051908515,-0.023481246,0.03609333,-0.018859688,0.01456923,0.05080188,-0.06443535,-0.037456878,-0.047279026,-0.017814938,0.07462364,-0.040046208,-0.04191016,-0.10249688,0.018244967,-0.016246092,-0.015624894,-0.03770193,0.119542845,0.072556145,-0.077482276,-0.043988585,0.07701923,-0.07870705,0.021935225,-0.029828511,-0.032270133,-0.092881404,-0.04788315,-0.049512573,-0.06281005,0.011736903,0.0001207596,0.062983215,0.011425271,-0.035903465,-0.08990724,0.017521944,-0.06934727,-0.07057435,-0.028948927,-0.0027354974,0.025703382,0.057557296,0.09326636,0.07305392,0.032832425,0.06788926,0.008084772,0.0076497793,0.009085122,0.06789863,0.017354634,0.02270055,-0.040614042,0.07778287,-0.004374041,-0.049085807,-0.004297645,-0.0037632359,0.031352393,0.058082446,-0.0765957,-3.1649285e-33,-0.024495022,-0.012363084,0.010263366,-0.09756023,-0.0037649944,-0.17019495,-0.08400071,-0.006458135,-0.011737798,-0.06721641,-0.01600904,-0.076849215,0.00090574037,0.0022388482,0.04035826,-0.04829951,-0.011920028,-0.011540789,0.023182549,-0.033623837,0.052270044,0.030023167,0.010269397,0.017714508,0.02915194,0.028496893,0.07066213,0.04563554,0.064465135,-0.026468653,0.044237826,-0.007745581,-0.09645964,-0.024817144,0.08996804,-0.013240881,-0.009251542,0.014068585,-0.058262024,0.013657229,-0.0027508116,0.08553941,0.017353063,-0.039903264,0.059431694,-0.08793019,-0.024215955,0.056328665,0.065850854,0.02082925,-0.027334018,-0.08194439,0.054183822,0.06075785,0.04332869,-0.011262022,-0.019885842,-0.029899262,0.04610577,-0.025024982,-0.09031486,-0.05443445,-0.03604038,0.039258514,0.0587041,0.09290122,-0.020558596,-0.023073828,0.07312991,0.06256427,-0.02644987,0.045324903,-0.0031971915,0.03791029,-0.01681663,-0.022170993,-0.08084136,-0.023458159,0.0289998,0.01915861,0.0034918564,-0.026932117,0.04150295,0.010309199,-0.021698851,-0.08016521,0.026024193,-0.05182744,0.024801508,-0.012249703,0.09864436,-0.054945488,-0.046937704,0.033879463,-0.0652452,5.309474e-34,0.0391123,-0.06028266,0.03981899,0.051416595,-0.021936355,0.020340824,0.03262534,0.052239023,0.007378396,-0.019754965,0.03011278,0.0946774,-0.012221718,0.02287971,-0.01410866,0.029879812,0.011907125,0.012922835,-0.04226013,0.009853911,0.0015437758,0.039554685,0.017267521,-0.025304196,0.050266862,0.073021345,-0.019426307,0.05354616,0.0005958341,0.042958736,-0.0029352126,0.039188497,-0.055231668,-0.06376331,0.031218559,0.066603884,-0.041082468,-0.049166966,-0.027756713,0.036499497,0.048891827,0.082049906,-0.012486972,0.08308179,0.008730079,0.05479528,-0.010067714,0.106572464,-0.05810847,-0.08417145,-0.069302164,-0.014786189,0.0094497055,0.031708326,-0.041149464,0.016222384,0.07704646,0.01575283,-0.025833081,0.048349287,-0.025414674,-0.06376874,0.04570625,0.02497198,0.0024581181,-0.023837779,0.06288032,0.06553544,0.02407734,-0.03441508,0.022998631,0.0017125258,0.0825136,0.016859455,-0.009513342,-0.023836212,-0.15012091,-0.0367426,-0.036186002,0.0049226736,-0.04443208,-0.005791384,-0.0703653,-0.056257267,0.019260751,-0.078505315,-0.031046757,0.048319377,-0.046629664,0.06324041,-0.009490662,-0.048543837,-0.017356744,0.043067366,0.003009513,-2.1095703e-08,0.056093507,-0.008874892,0.08649612,-0.056286734,0.067851156,0.03207015,-0.09126717,0.046020143,0.05535505,0.0044860723,-0.006698059,0.0011742081,-0.05117109,-0.031832997,0.02187902,0.01270728,-0.0005990079,-0.04693375,-0.060163006,-0.020915486,-0.044121284,-0.037255555,-0.14406879,-0.013234585,0.038626656,-0.045172606,0.013760505,-0.020259555,-0.08708746,-0.03788021,0.0016724558,0.13007124,0.068035044,0.0049136323,-0.100697406,0.043709446,0.047995873,-0.045446243,-0.02819922,0.028269896,0.0053541,0.0685418,-0.15951295,-0.03228031,-0.011658372,0.03610758,0.031869557,0.008852806,-0.047885902,-0.038535617,0.03342899,-0.056838658,-0.0092200665,0.03234728,-0.056543637,0.002026901,-0.024065886,-0.021447103,0.049274966,0.041568354,0.0072517125,-0.018335592,0.08703573,-0.048677076 +2.7.4.30,"The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.",384,1.0,-0.04068853,-0.02918945,-0.021479836,-0.0601334,-0.011014141,0.047678333,-0.03421827,-0.002230999,0.050524194,0.030996038,0.06323858,-0.07471935,-0.0763958,-0.018925192,0.004457645,0.071841165,-0.046516024,-0.009599415,0.0115707815,-0.07283989,0.11255424,0.005478521,0.007964118,-0.0033221876,-0.008387737,0.09634279,0.044149294,0.014414219,0.028256256,-0.059275944,0.005830926,-0.028302377,0.02189837,-0.080155656,0.013843395,0.084702656,-0.015016517,-0.027405828,0.044100188,0.04520031,0.11308013,-0.03955869,-0.00556951,-0.019102326,-0.04530582,-0.078532316,0.013121159,0.03903623,0.095312946,0.008409052,-0.013264609,-0.08012333,0.006560021,0.017321656,0.009913096,-0.005521916,-0.08674155,0.062094066,-0.06668352,0.08165981,0.029418958,0.04060034,0.049527578,0.033251192,0.05243993,-0.06980047,0.0681396,-0.08648794,-0.010431802,-0.101507984,-0.07324566,-0.059861384,0.05843243,0.01667702,0.015673373,-0.03254633,-0.044439413,-0.020005358,-0.0045697275,-0.05616174,0.04042261,-0.06623243,-0.035866536,0.040480573,0.021615375,-0.01886698,-0.0071199383,-0.03749794,0.054345574,0.044913407,0.005477542,-0.04965447,0.0047795447,-0.023767304,0.0022364645,0.021362491,-0.003537673,0.0276436,-0.01970798,0.023189355,0.005207922,0.06086332,-0.09337996,-0.08506179,-0.040272027,-0.028576782,-0.009641495,-0.021410936,-0.06913822,0.0023489422,0.0064467113,0.0010383982,0.05314523,0.024835153,-0.06041668,0.10494653,-0.012857967,-0.048691515,0.0061778985,-0.03768901,-0.008232237,-0.029311014,0.10355262,0.10133762,-0.024812512,0.08792829,-0.1139939,3.3884234e-33,0.038923737,0.035568014,0.0037266037,0.01696365,-0.047045734,-0.0027216657,-0.08079009,0.039176967,-0.08419807,-0.01984268,-0.07229674,-0.07174003,0.11383798,0.09171939,0.023990814,-0.039751273,0.016094772,0.017921146,0.14614102,-0.000240521,0.011733043,0.021307023,-0.020496568,0.073502615,-0.0050915806,0.07481445,0.0044072,-0.026304837,0.045260504,0.027442109,-0.036027223,-0.021911442,-0.09604549,-0.08051849,0.02213405,-0.02447497,-0.039287273,-0.057912838,-0.038752448,0.0046316185,-0.025082126,0.019467847,0.026315296,-0.05704175,0.013011177,-0.0529634,-0.08855609,0.012876862,0.11433318,0.060839925,-0.0017859951,-0.05151456,0.14610694,0.0043408796,-0.05815591,-0.0073311655,-0.04778349,-0.021632686,-0.0032149157,0.026608681,-0.006334638,0.060523167,-0.10542714,-0.022237234,0.014853548,0.011922172,-0.04712854,-0.101695605,-0.036359716,0.037125815,-0.0036311503,-0.014837671,0.050472967,0.08207647,0.030171072,-0.046832196,-0.012830168,0.038738113,0.021188796,0.020338085,0.017328788,-0.010354477,0.015943907,-0.06586772,-0.040274527,0.010237547,0.015128133,-0.039557893,0.02843829,0.005519179,0.0087567195,-0.04655598,-0.0565516,0.015316536,0.03501173,-5.6544382e-33,0.04583601,-0.050645325,-0.033009395,-0.090668425,-0.01266173,0.047970966,0.11834358,0.0026833275,0.0785604,0.0008205495,0.06542787,-0.022392556,0.024449456,-0.07200175,-0.00021799917,0.04069208,-0.07100745,-0.02120228,0.015765138,-0.022838727,0.02316127,0.07937453,0.09883626,0.0701741,0.05818356,-0.0548362,0.028852401,0.11174706,-0.045020405,0.020049863,-0.0021501842,-0.04336883,-0.08823596,0.03634665,-0.08487469,0.043875962,-0.063980244,-0.023625014,-0.038147066,0.05591286,-0.022799602,0.079332225,0.04803735,0.033704195,-0.007366451,0.07592357,-0.035723723,0.028957086,-0.040274177,-0.098631375,-0.040202696,0.055124804,-0.01122613,0.052569192,0.0326935,0.016417995,0.0028293047,0.04188354,-0.019714048,-0.052210215,-0.03876263,-0.05982266,0.030973895,0.00062419806,0.029673392,0.010880828,-0.05375375,-0.020539718,0.0054266886,0.02000109,0.06340863,-0.04767301,-0.0002445652,0.04317277,-0.0061022798,-0.02315143,-0.07367444,-0.06314667,-0.013062541,-0.10715571,0.0074192723,-0.020778498,0.008262902,-0.054543167,0.039207727,0.0016002064,0.030717086,0.10777012,-0.0067305914,0.05904657,-0.0033805952,-0.0034878645,-0.100644,0.040458035,0.057099722,-4.607624e-08,0.0540861,-0.053427275,0.055107687,-0.031044414,-0.016426269,0.017501019,0.0015751525,0.036568593,0.028183091,-0.080172405,-0.017981382,0.11720671,0.022586688,0.06371062,0.042668726,0.048536096,-0.03774789,0.08100306,-0.028592551,-0.07734823,-0.00867343,-0.03679554,-0.08925783,0.03628541,0.0048849043,-0.011498411,-0.027454581,0.031968717,-0.02131127,-0.0049099484,0.033458415,0.008719839,0.007924225,-0.079990804,-0.02528417,0.018672101,-0.08087222,0.026729861,-0.05479199,0.07553341,0.017291503,-0.10613686,-0.11799875,0.011963134,0.036367834,0.040651694,-0.022038937,0.0006136254,-0.010529582,0.044100255,0.06313891,-0.010734556,-0.006448805,-0.015204542,-0.068316005,-0.06849804,-0.07746918,-0.074552156,0.04442219,-0.0640943,0.059876528,0.056031812,0.1419446,-0.022812974 +2.7.7.88,"The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses and lyssaviruses) is specific for mRNAs with sequences starting with AACA. cf. EC 2.7.7.50, mRNA guanylyltransferase. ",384,1.0,-0.10682592,-0.08430098,-0.059535135,-0.021929009,-0.021997994,0.024560373,-0.028015329,0.0039759562,0.084017515,-0.02451822,0.037883773,0.027490834,-0.02293715,0.0675394,-0.095365435,0.0018460334,-0.07936277,-0.06246168,0.0046020723,-0.029006597,0.07445587,0.12946142,-0.01072315,-0.08560162,0.022052743,-0.031255513,0.008968669,0.04062262,0.062845856,-0.049294546,0.031583242,-0.05045343,0.08626579,0.054097544,0.035295248,0.07804703,-0.05442889,0.015778463,0.0025679558,0.055745713,0.027376078,0.05876782,0.019616898,0.041098904,0.037480153,-0.025312448,-0.05656463,-0.012678787,0.03531503,0.034277853,0.0048635844,-0.034380767,-0.05680352,0.046436325,0.010096967,0.035450082,-0.10928415,-0.031996284,-0.022591652,0.033408143,0.07031965,0.028991055,0.010636085,-0.052039262,0.07505741,-0.030209683,0.039722115,0.09568543,-0.0014346773,0.050948348,-0.03504527,-0.04217223,-0.076762736,-0.0069714403,-0.033335406,0.049666565,0.0311143,0.012374523,0.02009559,-0.0330425,-0.025093026,-0.029439231,0.11716073,0.051051654,-0.06694239,0.005906286,0.0015749823,0.030172892,0.04689219,0.07320631,-0.054075126,-0.039211754,0.07664328,-0.008375396,0.0071478942,0.02429254,0.004722905,0.04776033,0.021216966,-0.013554559,0.024529176,-0.02015712,0.027617082,-0.039828513,-0.029427674,-0.019852033,0.04159823,0.035184726,0.03281156,0.022990761,-0.02928768,0.101351604,0.04793923,-0.06346004,-0.012757789,0.0020913237,-0.055202823,-0.050453946,-0.05078532,-0.006595031,-0.0572926,-0.028142015,0.009282683,0.046114188,-0.029768756,0.10133011,-0.06485555,6.3550517e-34,0.029131649,-0.054854684,0.029096803,-0.0223562,0.028452814,0.029332424,-0.0760354,0.020621937,-0.08652043,-0.050943147,-0.0028051105,-0.05574688,0.025431128,0.022670431,0.038360067,-0.013445666,0.005946241,-0.03002236,-0.013861793,0.00073343026,0.07311974,0.0010134941,-0.003922906,-0.035083774,0.013752355,-0.03134758,-0.015361909,-0.043390155,0.014855014,-0.059080396,-0.060793765,-0.023678374,-0.008082577,0.03696233,0.030464083,-0.012661759,-0.0040975558,-0.017297635,0.044570044,0.0054169972,0.08425983,0.066244915,-0.0027425764,-0.010512894,0.06864888,0.0010365878,-0.03788695,0.03545227,-0.10034798,0.042863727,0.07181304,0.013864253,0.053324953,-0.059259392,-0.0028721702,-0.029862246,-0.05259588,0.056292113,0.010462826,-0.0027790014,0.0009006602,0.0036434324,0.051218573,-0.0076802885,0.008463709,-0.02750661,0.004016107,-0.052670486,-0.017889747,0.09461123,-0.045068227,-0.023313783,0.03157822,-0.009571788,0.01586712,-0.023136353,-0.10781634,-0.014068809,0.01893502,0.050995957,-0.091341324,0.016677912,0.024575291,-0.04269498,-0.05481328,-0.04141857,0.026076553,-0.07485842,-0.009145232,0.0029357597,0.06841293,-0.023823122,-0.070026636,0.0030775855,0.018734213,-1.4013748e-33,0.012387141,-0.043676484,-0.029860223,-0.019143263,-0.04732083,0.034312025,0.09612454,-0.01618989,-0.013868754,-0.015076128,0.011214456,0.005811029,0.046694204,-0.06787711,0.060779076,-0.015368637,0.026699597,0.09327396,0.05797986,-0.039195392,-0.015650634,0.04198943,-0.07039617,0.0131536,0.021807801,0.0069133798,-0.0010844768,0.12792358,-0.041116692,0.004086019,-0.029761273,0.030714184,-0.030710729,0.020230852,-0.08946909,0.015353728,0.018428715,-8.2758874e-05,0.012711773,-0.06384426,0.06136516,0.12642562,-0.012781024,0.12219102,-0.045583863,0.04358386,-0.051343776,0.04745075,0.03319248,-0.058995444,0.0025815999,-0.015277841,0.035721667,0.05230802,-0.007680174,0.019581512,-0.031805865,0.032409202,-0.007939782,0.013486496,-0.044164296,-0.09054588,-0.047865286,-0.070708685,0.04803661,0.046563353,0.04737028,0.084394306,0.04206111,-0.16865356,0.1265871,0.0325043,0.021532308,-0.023587046,-0.009124172,-0.09413633,-0.010387093,-0.05237281,-0.034424342,-0.106973745,-0.059539188,0.0070144096,-0.01431297,0.014079533,0.056900177,0.00012844379,0.041794192,0.044721488,0.031033948,0.08417278,0.023623047,-0.06474174,-0.05292364,0.0047796085,0.018813636,-3.34165e-08,0.031060109,-0.034631938,0.006916059,-0.06211427,0.050646868,0.10393922,-0.07078929,0.051413324,0.056446142,0.0931176,0.07178763,-0.022932662,-0.10388444,-0.026544245,0.026510682,0.05015229,-0.016146878,0.10961703,-0.048132062,-0.0006823485,-0.07140896,0.06561005,-0.14017315,0.06334748,-0.05693283,-0.04826838,0.053117033,-0.013074671,0.04597663,-0.13899732,-0.06482444,0.05748235,0.049152464,-0.06641395,-0.11365858,-0.033066373,0.067750886,-0.008621217,0.044378143,-0.0064130602,0.024879666,-0.05283863,-0.005345303,-0.017724179,-0.11292488,-0.029409487,-0.024347667,-0.041348774,0.05120484,-0.0014484723,0.112936646,-0.0027701017,0.035243083,-0.061215956,-0.08277469,-0.028257122,-0.06263804,-0.02728872,0.028473362,0.015911037,0.023525085,-0.020554196,0.15454896,-0.041131884 +2.7.7.89,"This bacterial enzyme removes an adenylyl group from a modified tyrosine residue of EC 6.3.1.2, glutamine synthetase. The enzyme is bifunctional, and also performs the adenylation of this residue (cf. EC 2.7.7.42, [glutamine synthetase] adenylyltransferase) [3,5]. The two activities are present on separate domains.",384,1.0,-0.038708955,0.0061110393,-0.03263563,-0.034749746,-4.2095176e-05,-0.01971925,0.017722748,-0.01482422,0.073738866,-0.01580406,0.064988874,-0.04823747,-0.022874482,0.019475223,-0.023560474,0.012676856,-0.11779722,-0.04934289,-0.0015130794,-0.09035228,0.027398586,0.122978814,-0.0074263196,0.031417783,0.031141322,0.021632122,0.06684412,0.00823014,0.011053083,-0.0599557,-0.031774122,-0.04988607,0.06095051,-0.04536962,0.101343974,0.07352739,-0.060346562,-0.02233925,0.114930555,0.013518039,0.010809512,0.0074449736,-0.04672107,-0.041880727,-0.053752523,0.052969176,0.085720316,0.055798154,0.025834238,0.0016585167,0.06047934,-0.07628175,-0.022140512,-0.007503259,0.07744959,-0.004307526,-0.0873268,-0.05776108,-0.012771807,0.024368796,0.03191375,0.005163774,0.01267407,-0.05022434,0.038720265,-0.06484765,0.11349486,-0.13255411,0.024737343,-0.08032317,-0.07327252,-0.08703428,0.0625926,0.020003771,-0.022254577,-0.016495258,-0.010081738,-0.019351635,0.048795305,-0.008458364,0.04683852,-0.07875159,0.031920895,0.053713065,-0.0027817287,-0.058679886,-0.005536209,-0.022361672,0.0642399,0.005868478,0.029904732,-0.01948019,0.044896334,-0.087950744,-0.0040199487,-0.036779813,-0.0082604,0.017462138,0.04543411,0.023213184,-0.020331565,0.051746447,-0.059025556,-0.01503574,-0.03523419,0.020241734,-0.0019255333,0.12792966,-0.0005889331,-1.2599889e-05,-0.03017279,0.06763556,0.043264885,0.015978906,-0.05868063,0.10383612,0.05908298,-0.029991658,-0.07732481,0.020615738,0.006221228,-0.032599885,0.08384965,0.108849086,-0.050875135,0.0469771,-0.043147378,2.002858e-33,0.029584957,0.048157267,-0.000619528,-0.0902317,0.034830477,0.00016590685,-0.07848278,0.006213817,-0.020668406,-0.060218237,-0.09659967,-0.06403148,0.05779033,0.017309967,0.03274953,0.017374054,-0.04954007,0.013672746,0.04187943,0.0084678205,-0.00038295196,0.059769478,0.01694501,0.011892669,-0.027339727,0.06448778,-0.043308496,0.027738443,0.06506244,-0.015320689,-0.016537555,-0.0719793,-0.105559796,0.022816075,-0.005954505,-0.012196324,-0.049070906,-0.03239214,0.018731847,0.079532295,-0.028460218,0.046031475,0.023623738,-0.08897813,0.043549594,-0.03903502,0.029590724,0.10096221,0.03410119,0.09934193,0.04275423,-0.03579772,0.09202196,-0.07893645,-0.06827421,0.013392662,0.0072782263,-0.0430198,0.02895893,0.04568431,0.057316296,0.061496835,-0.024603266,-0.040354602,0.0039279237,0.030667834,-0.028144684,-0.054829903,0.017925125,0.07278352,-0.02222482,0.012956957,0.07549388,0.10565006,-0.036977954,-0.004997351,-0.077200234,0.034131326,0.007308411,-0.02887386,-0.006035802,0.041474566,0.06064186,-0.025010213,0.0017555136,-0.03510004,-0.02066692,-0.04362742,-0.060713544,0.04726764,-0.004639166,-0.04947433,-0.09962759,0.015364782,-0.013096639,-2.710117e-33,0.11369528,-0.060290482,-0.030321028,-0.092569135,-0.0416641,0.041177522,-0.009897097,-0.0039002046,0.015450416,0.013907658,0.04908171,0.028194113,0.058998007,-0.06622401,0.022735205,-0.08124259,-0.0140512725,0.055678956,-0.088008575,-0.01989265,0.0639813,-0.015941264,0.013994408,0.012388745,0.00016565442,-0.002477035,-0.013417308,0.04228082,0.04190804,0.036633283,-0.07655981,-0.0049520233,0.0131717585,-0.026420642,0.051594142,0.03477711,-0.037951164,0.02864269,-0.011168255,-0.0028865722,0.041721668,0.0901671,2.885543e-07,0.07425794,-0.0044044005,0.13706698,-0.0267607,0.039584283,-0.07167452,-0.066848435,0.023247007,-0.0048748623,0.05069092,-0.060126998,0.011391347,0.04813832,0.06065736,-0.030558068,-0.006753379,-0.004097745,-0.012939829,-0.026460331,0.0071542696,-0.020659072,0.036625452,-0.015260739,-0.026145883,0.05375196,0.028330255,0.011771068,0.02425019,-0.05919955,0.04574377,-0.010097712,-0.024111634,-0.0067859055,-0.03048053,-0.0723909,0.04576102,-0.07365631,0.034339763,-0.043278787,0.02475438,-0.012779654,-0.0019119878,-0.008015864,0.028985102,0.13632107,-0.011196245,0.048429523,-0.011428437,0.0039533437,-0.019099971,0.038298335,0.016359236,-3.8709146e-08,0.049258936,-0.098745346,0.008729346,-0.042074468,0.011887421,0.116347075,-0.049137585,0.052386586,0.0427898,-0.068179704,-0.020822454,0.06610494,-0.047787465,0.0009365952,-0.103409104,0.015952183,-0.065603025,0.026685247,-0.02767321,-0.089532524,-0.117089406,-2.4914547e-05,-0.10380059,-0.005564251,0.054208193,-0.04662003,0.00731109,0.086992234,-0.08259774,-0.030161297,0.018457884,0.005623892,-0.0583917,-0.025042087,-0.05167809,-0.030421136,-0.04310829,0.0068826065,-0.025180014,0.084505446,0.04021891,0.019628318,-0.08691968,0.011722373,0.03486856,0.053497728,-0.01107884,-0.0001044973,-0.03720164,0.032654557,0.09405666,-0.02617546,-0.018309759,0.006714658,-0.11163847,-0.047737222,-0.056469664,-0.090148225,-0.019463658,-0.050999377,0.046064775,0.030558709,0.17828001,-0.019369941 +2.7.8.42,The enzyme has been characterized from the bacterium Escherichia coli. It is activated by Ca2+ ions and is silenced by the sRNA MgrR.,384,0.99999994,-0.065142915,-0.06460467,-0.053303372,0.06476784,-0.011836806,0.020801468,-0.042212687,0.04688816,0.051478334,-0.016315958,0.052999508,-0.008328438,0.040396784,0.05893704,-0.02379696,-0.012391745,0.007043652,0.050598186,0.008178827,-0.072909445,0.12966262,0.061461005,-0.05232073,0.015062771,-0.019216266,0.023098407,0.054808777,-0.0379713,0.009680904,0.008930924,-0.039975736,-0.031683534,0.10655215,-0.09832987,0.037303194,0.076717414,-0.063820645,-0.039843798,0.0055738795,-0.049021576,0.014831689,0.0251904,0.043369174,-0.050715875,0.0209726,-0.042320877,0.04838993,-0.04621089,0.016870748,-0.026317615,-0.02853081,-0.05721773,-0.050300065,0.030417291,0.053367283,0.029198496,-0.07194706,-0.03336368,0.010756693,-0.030760378,0.03232059,-0.0035412414,0.037670188,-0.009769601,0.08401275,-0.040212967,0.0075076986,-0.061224937,0.062001877,-0.07483051,-0.054917313,-0.040459707,0.03750315,0.008868117,-0.0022107048,-0.074396186,-0.00680606,-0.048744652,0.096379355,0.042025503,0.062334683,-0.08017803,-0.007720248,0.090750076,-0.0026332636,0.08314169,0.10737922,0.030577142,0.023406573,0.010820608,0.0815776,0.024965553,0.013472685,-0.061078716,-0.056265198,0.0014366189,-0.048880577,-0.013317676,0.028350456,-0.025255477,0.04641515,0.07477819,-0.039418362,-0.06822167,-0.062754214,3.7196525e-05,-0.029191805,0.10085741,-0.030358769,0.048255447,0.06667854,0.032935392,0.00885388,-0.022884643,-0.011404794,0.13596359,0.025013106,-0.044803265,-0.0473763,-0.027328765,-0.0070223673,-0.04802462,-0.02903147,0.0033990422,0.027782856,0.037807368,-0.10280255,-2.5732632e-34,-0.0041674674,-0.024000784,0.011265542,-0.034863062,0.03065197,-0.033335846,-0.019608142,-0.035773735,-0.03878574,-0.029204385,0.01645826,-0.055619497,0.0045202333,0.015899407,-0.010452617,-0.006973195,-0.048615865,-0.036788795,0.062546775,0.033365514,0.074953206,0.06580423,0.047131665,-0.0087505365,0.04556149,0.049236406,-0.042136926,-0.0017709521,-0.002382628,-0.011706583,0.049319524,-0.05817084,-0.123869464,0.039683353,0.0723172,-0.04303483,0.01364526,-0.02566843,-0.028228406,0.070911005,-0.04118685,0.035151888,-0.022275448,0.006487212,0.08941209,-0.07662029,-0.072483525,0.09657676,0.09245343,0.12983084,0.07409758,-0.01769916,0.04220183,-0.04976211,-0.062076602,0.03340747,-0.0046992614,0.008116798,-0.034605727,0.0008741232,0.020988377,-0.004558573,-0.040829126,0.06625142,0.046827905,0.075687826,-0.056928143,-0.04957147,0.058210082,0.07534105,-0.062136784,-0.011287156,0.046269197,-0.015701758,-0.058392335,-0.018909125,-0.10358566,0.052940678,0.044480808,0.024071794,-0.046800856,-0.028716162,-0.0012382523,0.015956365,-0.06184039,0.018769758,-0.031218532,-0.045794453,-0.024625605,0.037929725,0.0873275,-0.050745793,-0.049155213,0.07201324,-0.031057922,-1.4142304e-33,0.08682835,-0.045374483,0.055721138,-0.03009397,-0.061779577,0.045285333,0.0014544948,-0.011362541,0.0202119,-0.012422447,0.060155265,0.0554305,0.015334284,-0.004884474,0.027797125,0.025298472,0.03474521,0.06597417,-0.051051058,-0.011322403,0.014603169,0.08472216,0.012230391,-0.048462104,0.09714599,-0.031124506,0.05258445,0.07035014,0.03042506,-0.0034426805,-0.0076920902,0.0021145502,-0.034908954,-0.042517077,-0.09130003,0.004791013,-0.021923661,0.0357124,0.040957484,0.0152131105,0.00432241,0.030934265,-0.072604574,0.106167175,-0.02768379,0.09715146,-0.011629607,0.050322212,0.042844843,-0.09974651,-0.004647242,-0.08100544,0.007181586,-0.03436377,0.012309975,0.020162284,0.010005986,0.024034409,-0.037123773,0.032259583,0.0103829065,-0.055883575,0.023300417,-0.046197116,0.0069227125,0.0877861,0.0039123083,-0.022523228,0.02031082,-0.073694766,0.110933244,0.018092284,-0.0026202677,0.004304145,-0.06796277,-0.018032826,-0.09206703,-0.066577815,0.03553006,-0.035688892,0.042357635,0.031039892,-0.0390225,-0.034771007,0.05955957,-0.071403265,-0.026364986,0.080226906,0.066956274,0.017794302,-0.07695503,0.0055446513,-0.04153157,-0.017913345,0.04116731,-2.7989568e-08,-0.023353104,-0.09385319,-0.006373979,-0.06647108,0.030786643,0.100291975,-0.018138884,-0.04267416,0.06473946,0.014743691,-0.017813291,0.01576089,-0.09247006,0.012473376,0.028314257,0.042292707,-0.039954484,8.342619e-05,-0.04928037,-0.08080323,-0.0873994,-0.06491846,-0.13878179,0.035188947,0.0078086746,-0.07411906,0.022152988,0.06196437,-0.03463845,-0.047238756,-0.04908988,-0.02852628,0.058110308,-0.037416313,-0.08297884,0.04249961,-0.004438577,-0.0327307,-0.035154153,-0.027635388,0.04780686,-0.036209054,-0.04275244,-0.005760273,-0.06857627,0.058450248,-0.026575541,0.0037642522,-0.03569274,0.03636252,0.105533265,-0.08912906,-0.015868569,-0.034189258,-0.12925138,0.044403795,0.03986627,-0.07417023,-0.021454671,0.0015718639,0.07650195,-0.00057538884,0.15098712,-0.06729113 +2.8.1.13,"The enzyme, found in bacteria, catalyses formation of the 2-thiouridine modification in the wobble position of tRNAGln, tRNALys and tRNAGlu. ",384,1.0,-0.0635369,-0.072853215,-0.13865991,-0.037505075,-0.012469047,-0.018415349,-0.0359133,0.08026223,0.020413002,-0.019872911,0.018542994,-0.036628176,-0.05380291,0.011268682,-0.053735122,0.018420098,-0.10633824,0.006800372,0.037285745,-0.07350298,-0.015911516,0.04272496,0.0037526174,0.031122576,-0.009120076,0.032255102,0.06901047,-0.005279724,-0.011205405,-0.061907593,-0.033509534,-0.02690953,0.06509977,-0.039098624,0.071546935,0.072986655,-0.09699289,-0.022052744,0.12030537,0.0017169748,0.04083124,0.013326709,-0.014268171,-0.019630462,-0.03201716,-0.011280402,0.08149819,0.12499076,-0.014795611,0.1269871,-0.08633746,-0.028388448,-0.026954176,0.033932496,-0.034584336,0.03650088,-0.014078586,0.04417703,-0.017824437,0.045009505,0.1152751,0.044394642,0.03864753,-0.011109593,0.0316351,-0.07753045,0.045452315,-0.01711321,0.06868552,0.0019445515,0.02820916,0.04313796,-0.007075748,0.030129528,-0.017367154,-0.048436955,0.016927568,-0.030223496,-0.0029663332,0.05665734,-0.001970094,-0.020768782,0.042904653,0.044447087,-0.013028916,-0.025311874,-0.010590554,0.030463576,0.059570294,0.036068037,0.12769921,0.03365834,0.021631615,-0.061024375,-0.03538231,0.00824709,0.0023405596,0.046939146,0.06123562,-0.02467487,-0.05285757,-0.031795904,0.0027734959,-0.007821762,0.004360484,0.009693151,0.010106832,0.007841902,-0.0037410709,-0.0089378785,0.016443675,0.039537463,0.11712186,0.060197596,-0.03808103,0.07878532,-0.005050007,-0.039136965,-0.04125612,-0.0021731297,0.0039756587,-0.06614378,0.027539277,0.041005537,-0.05433622,0.0014813241,-0.121833414,2.1511997e-34,0.05960941,-0.0038085382,-0.0026761775,-0.05401159,0.060071338,-0.06589839,-0.06828802,0.020488234,-0.08842828,-0.031837527,-0.08673446,-0.09540731,0.03312218,-0.0034586785,-0.0036098154,-0.08732551,-0.030173032,0.034850292,0.018332163,0.03634646,-0.009747003,0.0888194,0.014886993,0.014387441,-0.033980224,0.112002105,-0.028586872,0.023900358,0.047242813,-0.0046433127,0.04015979,-0.102762364,-0.06474156,5.17057e-06,0.11050154,-0.061814606,-0.08599031,0.0020476163,-0.072985776,0.023597253,0.017739465,0.009365082,-0.0062263776,-0.021083634,0.020325394,-0.028703962,-0.014809752,0.060355645,0.009173537,-0.00020941331,0.04078647,-0.030082762,0.043725513,-0.031866267,0.008953362,-0.035059407,0.020135995,-0.024778418,0.05432733,0.029784476,0.03137488,0.010321162,0.036090884,0.003247262,-0.039236523,0.013535406,-0.057095736,-0.04298898,0.036641456,0.057772025,-0.0138695,0.005036228,0.03432197,0.019327462,0.033691425,-0.02890503,-0.057604037,-0.03163483,-0.03634185,-0.08110767,0.0154013755,-0.0389319,0.0050672796,0.025656696,-0.07565138,-0.0038440952,-0.012467004,-0.042440005,-0.007822825,0.08819606,-0.0751798,-0.06760917,-0.077717915,-0.014248145,0.04536074,-1.7752426e-33,0.023245718,-0.13242784,-0.0017920583,-0.044507314,-0.1335259,0.08740447,-0.06192582,-0.038561273,-0.0028108817,-0.020170165,0.09747936,0.007077191,-0.07842768,0.023365328,0.021822719,-0.011270519,0.06929356,-0.019381173,-0.055419847,-0.10301898,0.045984108,-0.016777584,-0.025001327,-0.0108988695,0.032745257,0.009613899,0.052363064,0.03379192,0.024093501,0.1004063,-0.07964959,-0.056654114,-0.006661971,0.02875827,0.011810389,0.054695453,-0.01336238,-0.032464754,0.0394784,-0.03742869,0.07115916,-0.03099095,0.05006128,0.077357985,-0.02241026,0.08621676,-0.048799273,-0.042293314,-0.07409309,-0.06691753,0.11426322,0.009854663,0.034829747,-0.040571168,0.08136352,0.062141765,-0.050228275,0.002358651,0.00020314475,-0.07206461,-0.046790775,-0.07688057,-0.025492141,-0.058610015,0.023870897,0.03198526,-0.084030926,0.08037968,0.04658837,-0.030669758,0.028309014,0.009238407,0.050627522,0.04709048,-0.043475226,-0.01026544,-0.0517248,-0.07907317,0.052506696,-0.035188105,-0.04877737,-0.032664623,0.02177026,-0.048253175,-0.0060687256,0.001935969,0.01823654,0.13112058,0.00075699337,0.08868293,0.03276593,0.025454061,0.009370507,-0.0034542773,0.07168013,-3.0695738e-08,-0.019261392,-0.12157443,0.0030052615,0.034697186,0.0015520398,0.08992287,-0.001862526,0.05057683,0.026344733,-0.034145523,-0.023226153,0.07153341,-0.016127832,0.012674764,0.020364244,0.041135736,-0.12823187,-0.053262766,-0.026405975,-0.03444544,-0.07333228,0.051796917,-0.10722961,-0.0057923333,0.0024614464,-0.017088529,-0.047439896,0.0038741082,-0.049378566,-0.033642907,0.03462589,-7.0809685e-05,0.016328868,-0.0037366515,-0.017833985,0.01474188,-0.027905835,-0.05522678,-0.010693809,0.022183683,-0.013403644,0.094853945,-0.09516557,0.015185573,-0.054927636,0.01714943,0.019342542,0.07667215,-0.03412626,0.02816418,-0.001798546,0.06283758,0.02505774,0.04669988,-0.05745416,0.015300514,0.0032068577,-0.08934587,-0.08596019,0.052234292,0.003543299,0.04035816,0.1772206,-0.01382538 +2.8.1.14,"The enzyme, found in mitochondria, catalyses formation of 5-taurinomethyl-2-thiouridine in the wobble position of mitochondrial tRNAGln, tRNALys and tRNAGlu. 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In addition to caffeate, the enzyme can utilize 4-coumarate or ferulate as CoA acceptor. 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+3.1.1.98,"The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.",384,1.0,-0.028246721,-0.054052185,-0.04643823,-0.027741866,0.14627846,-0.004602552,-0.02937817,0.04338692,0.05646421,-0.016054474,0.085047476,0.043719735,-0.115587056,-0.012659902,-0.022889834,0.022849293,-0.08034472,0.023340251,-0.022888957,-0.02564615,0.1519896,0.06074356,0.09165683,-0.0817905,-0.018463673,0.038818974,0.013522926,-0.0034827425,0.07931681,-0.02829149,0.008555826,0.04893754,0.013417848,-0.03595001,-0.010805234,-0.0073127127,-0.0060563297,-0.05846223,-0.06360847,-0.0015942036,0.117690496,-0.033457395,-0.033552546,-0.016753435,-0.027449548,-0.06166645,-0.055282585,0.04756772,-0.006497805,0.067401886,0.00029705782,-0.07779447,-0.0052154628,0.023265671,-0.04780769,-0.0056152917,0.007365837,0.032329038,0.061074078,0.026026038,0.025038557,0.08251142,-0.0022172558,-0.060624287,0.11908471,-0.112541296,0.03986831,-0.04368492,0.012504011,-0.06589116,-0.093177274,-0.050854996,0.0064085308,0.071270525,0.0029790662,0.06796011,-0.05798807,0.057825368,0.04834941,0.029648708,0.07798802,-0.031131312,0.016104573,0.09712729,0.070387065,0.01895761,-0.083111346,-0.0056879576,0.048130505,-0.045971896,0.0064674723,-0.13390923,-0.09058446,0.03720461,-0.016986089,0.02188853,0.020233141,0.06190578,-0.038980052,0.033237394,-0.032957654,0.04597633,-0.024320303,-0.08421669,-0.059442494,-0.006475293,0.013551087,0.06872896,-0.0138137685,-0.079618216,-0.026432758,0.02811089,0.05686837,0.013987659,0.002638106,0.0030203017,0.013593618,-0.01599518,-0.05417775,-0.015693191,-0.007354164,0.0014372059,0.054902982,0.039071783,-0.023129165,0.047681082,-0.03964013,-3.095696e-34,0.10297941,0.0518884,0.044387586,-0.0571278,-0.026301809,-0.07793197,-0.06837528,-0.052406207,-0.018637499,-0.02331794,-0.014285702,-0.040686842,0.026294958,-0.027101794,0.041081775,-0.060711723,-0.0050845956,0.017698806,0.0663035,0.008513342,0.06644311,0.11126513,-0.0047290334,0.040008787,0.026133018,0.0024444805,-0.047467895,-0.049375474,0.109087095,0.013284381,-0.025970718,-0.05968197,-0.07063495,0.0069449283,-0.050622735,-0.0015525036,-0.04915433,-0.13637863,0.03644444,-0.08008494,0.047829118,-0.034074076,-0.01441555,0.013543124,0.026793355,-0.09714362,0.0035243519,0.01363922,0.0655317,0.006300947,-0.0069159763,-0.046144158,0.058775812,-0.019238763,-0.10072126,-0.009752502,0.0024229018,-0.0142685715,0.024133105,0.040871844,-0.040367562,-0.016464869,-0.004212905,0.07631457,-0.036626965,0.002413019,-0.11294553,-0.025781495,-0.020572511,0.0817444,-0.033634435,-0.041218325,0.05202274,0.040312346,0.016066149,-0.057595752,0.0041551874,0.08618717,-0.055110436,0.017037842,0.07983985,0.04419449,-0.016096875,0.033676606,-0.05645812,-0.0147703085,-0.05988772,-0.10197262,0.03466148,0.0006791122,0.08478102,-0.0056533623,-0.06485749,0.028356345,-0.046042114,-8.4882245e-34,0.011239741,-0.0021919694,0.085033424,-0.0057992274,-0.076799825,0.048191875,0.01673908,0.028068861,0.021907689,-0.08463683,0.088061616,-0.0430997,0.03189783,-0.09837583,-0.0009939083,0.024175404,0.015293006,0.008581093,-0.019902429,0.0045944466,0.0651824,0.043871947,0.11828583,0.05639937,0.019804278,-0.009484292,0.038879365,0.053028964,-0.022296634,0.007144807,0.012866542,0.015385806,-0.0012407267,-0.006477817,-0.027311657,-0.025617454,-0.0036967476,0.029814465,-0.010946316,0.039363008,-0.00031374115,-0.021363659,0.046171896,0.009018386,0.04410735,0.04399762,-0.028204024,-0.027524466,0.0018889453,-0.022609368,0.03234581,0.053121023,-0.053796064,-0.016958563,0.01424739,0.059146017,0.06582177,-0.029739061,-0.046669718,0.060932476,0.015138502,0.05604705,-0.012843961,0.028404763,0.05842266,0.014269391,0.030261429,0.101588845,0.051277604,-0.031458925,0.03476807,0.06930626,0.112582095,0.059106246,0.045285128,0.008695209,-0.0441759,-0.04540145,-0.046861038,-0.10879893,-0.051833067,-0.026204618,0.0032340635,-0.1141374,0.0029908703,0.015374992,0.022355694,0.076354526,-0.026229952,0.04075568,-0.083099395,-0.0688835,-0.059189036,0.027439997,0.057100166,-2.8105113e-08,0.0073169665,-0.05450675,0.01400575,-0.04316041,-0.0780704,-0.0102636535,-0.0003901106,0.022768322,0.005844928,-0.007432447,-0.024587655,0.010954474,-0.021358017,-0.029260665,0.028193196,-0.003579274,-0.013126792,0.019868193,-0.023866033,-0.095055126,0.011418841,-0.025726063,0.029510347,0.06779656,0.03248842,-0.017505344,-0.0025162408,0.116297916,-0.00067773275,-0.063191816,-0.01278374,0.0031481378,-0.020310804,0.04045962,-0.09022245,0.05868694,-0.035932485,-0.07508687,-0.046801455,0.13248608,-0.019867271,0.04195556,-0.06636866,-0.009516248,0.027260363,0.05014282,0.034800783,0.06844854,-0.003266526,-0.026403857,0.046273556,-0.014598122,-0.02442228,-0.08128974,-0.0906937,0.02088992,-0.04479301,-0.03530192,0.09989799,-0.080984734,-0.011698019,-0.07115917,0.112243585,-0.018775709 +3.4.24.88,"The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolysing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. The enzyme contains Zn2+. cf. EC 3.4.19.12, ubiquitinyl hydrolase 1. In peptidase family M67. ",384,0.99999994,-0.06676787,0.0018549901,-0.08029002,0.012992413,0.061220616,0.025974194,-0.028894316,0.014982329,0.007611259,-0.07016421,0.0033648817,-0.03901597,-0.03286591,0.05079101,-0.11244899,0.005784856,-0.03869558,-0.006488612,0.0146601,0.00012765916,0.11831118,0.10348176,-0.055396426,0.041527808,0.07528136,-0.049315255,0.06654189,-0.022561975,0.0550019,-0.095679455,0.04047677,-0.0705621,0.04390467,-0.07345688,0.07303611,0.07027574,0.02280338,-0.1168376,-0.0028694735,-0.046072315,0.084378645,0.05429226,0.004178087,-0.003126962,-0.017425904,0.030431472,-0.0040298793,0.01883357,0.055950537,0.07007799,-0.048706234,-0.079636484,-0.013600626,0.019908551,0.04007147,0.01628404,-0.09336,-0.03891051,0.03775043,-0.030536003,0.011669502,0.07126441,0.029541062,-0.036027778,0.023351861,-0.044132512,0.013569739,-0.06137293,0.028824558,-0.08424855,-0.050983053,-0.02890602,-0.070301056,0.03585611,-0.050613835,0.025378104,-0.053515427,-0.019800344,-0.005557178,-0.03541443,0.008727742,0.00021302499,0.1020404,0.07603434,0.025574334,0.004088412,0.013149315,0.015650827,0.009491389,0.0043888744,0.06959849,-0.021084957,0.033333395,-0.011299521,-0.043691725,0.0106803095,-0.0054281848,0.007688159,-0.041289352,0.038928527,0.04583313,0.03732912,-0.0030349349,-0.115991496,-0.040978815,0.07016352,0.0006727919,0.08392013,0.06434542,0.010901795,-0.030996153,-0.013330554,0.027716247,-0.013333844,0.03861769,0.023880428,0.00071121677,-0.03946379,-0.04024902,-0.016758567,-0.03247859,0.010871188,0.023476781,0.05520303,0.0010356351,0.034503024,-0.17146362,5.5217822e-33,0.09490568,0.020543272,-0.0055418676,0.03168758,-0.06928183,-0.025548007,-0.07093482,0.0042100674,-0.041958,-0.08098245,-0.082988694,-0.014995997,0.021950407,-0.0076664393,0.023807824,-0.01937255,0.0029083048,-0.03089476,0.033427455,0.05324522,-0.07442041,0.02174749,-0.020561296,-0.041794907,0.06619624,0.019005891,-0.019517876,-0.06857233,0.012253131,0.013237394,-0.022831704,-0.07972414,-0.12600483,0.040082417,0.072407015,0.012731522,0.045186475,-0.08307861,-0.058225375,0.0011068251,0.043430187,0.014336795,-0.08915803,-0.009292897,0.087050945,-0.03644202,-0.01458446,0.102693655,-0.02037208,-0.031173468,0.032257624,0.026222382,0.07645841,-0.041107133,-0.10634169,0.06063703,-0.0020443043,0.037537895,0.074664585,0.041899815,0.008908343,0.012922246,-0.023066802,0.06355265,0.01239316,0.027312841,-0.060447387,-0.0005877986,0.016271513,0.063439064,-0.09605192,-0.06252748,0.086680576,0.04851215,-0.037310284,-0.14163871,-0.009943265,0.01973983,0.065902285,0.030932216,-0.044652607,-0.0065510897,-0.021987816,-0.032686207,-0.0065603144,-0.009402009,0.06405866,-0.048765726,-0.0341053,0.05582285,0.010867237,-0.047336955,-0.021874178,0.046733603,-0.015514774,-5.583693e-33,0.08291255,-0.13116288,0.0076089045,-0.014102522,-0.012917864,0.052343443,0.03102028,-0.012150161,0.0044742376,-0.09311755,0.09995063,-0.034304835,0.08715636,-0.085407846,0.05382131,0.023617025,0.010565863,0.067532524,0.057171393,0.00029824092,0.010072826,0.01021514,0.014279576,-0.02483772,-0.005081271,0.016831495,0.007762624,0.09369116,0.06985926,0.018769328,-0.032492187,0.06430159,-0.06704341,-0.09066032,-0.1285771,0.042957917,-0.03814029,-0.010314994,0.02730678,-0.027925264,0.012625911,0.0049354555,-0.055351157,0.04263471,0.058626723,0.08564649,0.010083272,-0.030978005,-0.038029548,-0.05931722,0.08720997,-0.045351468,-0.03445457,0.0893026,-0.021666218,0.019237047,0.035202038,0.08744409,0.027366595,0.014146385,-0.046187334,0.054440368,0.038013767,0.057920426,0.027661482,0.022919893,0.0419347,0.01275728,-0.0023092623,-0.0057465336,0.04411772,-0.049532857,0.10480426,0.07976052,0.024339866,0.051943444,-0.09992984,-0.012353934,-0.00744283,-0.07574486,-0.040741857,0.008156306,-0.014763143,-0.01253942,0.03345324,-0.05819333,0.059628718,0.12647699,0.012740358,0.025826009,-0.040459245,-0.019450871,-0.06897046,0.012818509,0.02713575,-4.4358796e-08,0.058474343,-0.042689417,0.012708301,-0.056300145,-0.018145803,0.049528193,0.0019439486,0.017634068,-0.062361516,-0.05735824,0.023977293,-0.012482392,-0.0040567974,-0.040607907,0.026168713,0.068906724,0.031419568,0.062704846,-0.023242718,0.0067088977,-0.03106829,0.050691392,-0.007895512,0.034875493,-0.03131366,-0.024256233,0.008493928,0.056581162,-0.0049522324,-0.05740748,0.0010116323,0.057968434,-0.011198136,-0.11559933,-0.056427192,0.07066002,-0.0032432147,-0.07029378,0.038827363,0.009875014,-0.028386243,-0.0284244,-0.04074811,-0.041505743,-0.006003356,0.022233749,0.066447645,0.032899205,-0.0328607,0.0083291065,0.024366649,-0.05818131,-0.061288405,-0.10212848,-0.050481115,0.018630508,0.03406808,-0.13387579,0.022942325,-0.1144562,0.013790294,-0.0053637265,0.0920027,-0.044286292 +3.4.24.89,"This metalloprotease, which is secreted by the bacterium Peptoclostridium difficile, contains zinc.",384,1.0,-0.109671846,0.035106406,-0.05636341,0.048906196,0.096630506,-0.021182237,0.037965436,0.05132279,-0.00041368563,0.0025254104,-0.028712684,-0.07281549,0.10566194,0.024653155,-0.05457399,-0.048873026,-0.03024621,0.013596588,-0.030899605,0.009989459,0.054606106,0.052823044,0.0232614,-0.031894404,-0.0012969737,0.05382624,0.02762307,-0.017043218,0.01334886,0.0029593632,0.018416984,-0.054530345,0.048158485,-0.024571078,0.08515561,0.012110822,-0.0222849,0.021192031,0.018682422,-0.016050238,0.066469386,0.08884332,0.032742705,-0.015558119,0.012410152,0.050314113,0.026590206,0.065662906,-0.0011366819,0.01796898,-0.069622256,-0.04994122,0.022997342,0.047429804,0.004328394,0.022327514,-0.036936827,-0.03062828,0.02062687,0.030928336,0.008756052,-0.068189576,-0.0022198644,-0.0018820994,0.013272503,-0.052887414,-0.037428565,-0.024365313,0.025159767,-0.024594627,-0.012274437,-0.022520682,-0.027669504,0.0389488,-0.01289585,0.10753118,0.0935313,-0.14234816,-0.027064282,-0.03410709,0.049190737,0.055291194,0.070358306,0.042392135,0.057871997,0.08165121,0.051991824,-0.00036346578,-0.03918146,-0.004832837,0.0048476215,0.0103358915,-0.003766933,-0.06200753,-0.122686096,0.033372425,-0.025330676,0.036126614,0.0028711979,0.026048858,0.007962888,0.028163271,0.04154377,-0.11212704,-0.021073151,-0.0046477783,0.025054296,0.11385448,0.03027227,0.03802107,0.02399536,-0.01567262,-0.024669053,0.003937689,0.061706647,0.02828865,0.08175499,-0.027575644,-0.093708135,-0.004828786,0.0016541493,-0.025488762,-0.0053178617,-0.0110618165,-0.05106926,0.03372165,-0.08754471,1.5462467e-33,-0.02694757,0.006555545,0.055607844,-0.003202693,-0.013576591,0.057535317,0.007468058,0.0062475754,0.023463534,-0.05729654,-0.06164771,-0.09022133,0.0036750764,0.014436395,-0.10583637,-0.06734834,-0.018058393,-0.0033307157,0.048988935,0.0084234215,0.065065,0.06601696,-0.011971667,-0.04888749,0.09922648,0.004007571,-0.037439045,-0.058927067,0.095738605,-0.02699034,0.031835824,-0.054572914,-0.0729209,-0.008252234,0.11569912,-0.03493585,0.0021355296,-0.03100218,-0.0016638298,-0.03927863,-0.03495854,-0.03377522,-0.1013609,0.036835805,0.045577593,-0.09185537,-0.04720434,0.059271865,0.004705078,-0.036327377,0.093056984,0.031313617,0.06397617,-0.09764172,-0.10044476,0.0664622,0.0030833527,0.029034186,0.09315791,0.038632277,-0.0034167336,0.12353194,-0.09816187,0.05594435,0.019874878,-0.005894147,-0.016556373,-0.024565594,0.011921932,0.09807665,-0.05459581,-0.02783786,0.04831404,0.022957005,-0.016789803,-0.008825042,-0.047447164,-0.024296755,0.13666008,-0.024969397,-0.01579043,-0.048485167,0.024272602,0.026615571,-0.0779738,-0.05072548,-0.03491886,-0.034077846,-0.03474999,-0.0021689807,0.07556373,-0.07024295,-0.08279435,0.031134628,-0.07352114,-2.5841565e-33,0.07136786,0.0001300872,0.05732966,-0.028835604,-0.015685517,-0.008904167,-0.053522978,-0.042387154,0.029390182,-0.012610809,0.09947092,-0.019428402,0.060215823,-0.012774728,0.037954144,0.044036455,-0.008307129,0.103955686,-0.010736533,0.001136743,-0.02501298,0.028448543,0.06545182,-0.017889248,0.036834504,0.008107222,-0.009230923,0.04538716,0.09382426,0.09137099,-0.02456413,0.11567848,0.016127469,-0.15301274,-0.11395137,-0.0012661753,-0.055374704,-0.0687947,0.023217496,-0.10041029,-0.06318485,-0.03078356,-0.004074758,0.09055904,0.027684405,0.071544096,-0.019315861,0.032353885,0.020757215,0.026868088,0.04058308,-0.0012408966,-0.036457784,-0.022214904,0.054782886,0.020929623,-0.01587172,0.0146751255,-0.027725935,-0.034594715,0.01148841,-0.026690582,-0.016659383,0.02152297,0.032209497,0.038852066,0.08050801,0.058366135,0.010537187,-0.028946802,0.087603785,0.09144794,-0.013069058,-0.073027566,-0.043399133,0.028959267,-0.035139646,-0.017878436,-0.042038128,0.07314369,0.012089469,0.003502364,-0.0015181903,-0.012876543,0.032185834,-0.07830545,-0.011310862,0.07243395,-0.09469658,0.042628106,-0.12266064,-0.068571955,0.010571805,0.05899723,-0.015671453,-2.6456172e-08,0.033403367,-0.04477551,0.07501431,-0.11948963,0.005218674,-0.0036555764,-0.039834667,-0.07048653,-0.0052377153,-0.033872962,0.05216663,-0.005686183,-0.005804657,-0.00050951575,-0.009029936,0.04811691,-0.044084996,-0.0576243,0.0034058127,0.011438437,-0.040542897,0.0068575707,-0.057291184,0.036553066,0.015800932,-0.066905454,0.013608614,0.008908815,-0.08417204,0.0022176693,0.005033355,-0.023681818,-0.03140808,0.013263666,-0.05816953,0.015130205,-0.01973996,-0.034058694,-0.039808046,-0.0015037582,-0.019563338,0.025962953,-0.027475594,0.011464199,-0.05846346,-0.042978227,-0.031445436,0.014988202,-0.021958921,-0.08059947,-0.0016928009,-0.053200986,-0.06055978,-0.056821,-0.008773956,0.07644183,0.0107602775,-0.08096215,-0.01953418,-0.017724894,-0.0368779,-0.011918775,0.2006685,0.020850208 +4.1.1.101,"The enzyme is involved in the malolactic fermentation of wine, which results in a natural decrease in acidity and favorable changes in wine flavors. It has been purified from several lactic acid bacteria, including Leuconostoc mesenteroides [1], Lactobacillus plantarum [2], and Oenococcus oeni [3,4]. The enzyme contains a tightly bound NAD+ cofactor and requires Mn2+.",384,1.0,-0.0078122215,-0.020236714,-0.10133663,0.013802438,0.07956282,0.056107976,-0.061837398,0.06907949,0.019673783,-0.06026395,-0.040949903,-0.006596869,-0.071906306,0.009331052,-0.09348535,0.036810726,-0.022319397,-0.001633501,0.028167555,-0.054533307,0.10493856,0.04865928,-0.002794961,-0.030665057,0.09335216,-0.0022607644,0.047706846,0.04400268,-0.0020186377,-0.041997712,-0.0064664413,-0.06317195,0.098890044,-0.06720033,-0.03355079,0.025752462,0.05663431,-0.10410981,0.05493247,0.011108295,0.050315104,0.053058345,-0.04086287,0.036401603,-0.039998055,0.011775734,0.01695301,-0.016435938,-0.005349334,0.052013773,-0.108270854,-0.06321544,-0.019867254,-0.022684967,0.04302991,-0.029350316,0.044602193,0.036361415,-0.022041487,0.034767404,0.07501487,-0.032072656,0.02068637,0.051521488,-0.009716372,0.0157535,0.013869608,-0.025203664,-0.0062006367,-0.09571038,-0.07240735,-0.066365115,-0.022590289,-0.006081766,0.0008951865,0.038689535,0.007140616,-0.05185402,0.018819263,0.034130692,-0.023011902,-0.019515764,-0.07598332,0.051137857,-0.051855084,0.001030544,0.035439633,0.009305621,0.05659714,0.03910651,-0.020273691,-0.04006491,-0.0834388,-0.10939114,-0.04317131,0.041520987,0.045118257,-0.0393719,-0.012615753,-0.050505843,-0.047917128,0.055137742,-0.0006659772,-0.12373882,-0.10164336,0.06760025,-0.0168555,0.08164567,0.04750956,0.037525326,-0.027770331,0.03978645,0.0019726148,-0.03841449,-0.033874404,0.08506767,0.09734621,-0.038107004,-0.079954594,-0.012012398,-0.00679517,-0.060798246,0.07432959,-0.008708818,-0.038685154,0.03480494,-0.011982176,2.237486e-33,0.045476336,-0.024988238,-0.023848891,-0.036589902,0.037208643,-0.025663108,-0.06672679,0.034492128,-0.019474037,-0.040134892,-0.045324218,-0.10776987,0.021878606,-0.0015259375,0.025436044,0.0104528405,0.0631155,-0.10453056,0.017900005,0.04416122,0.021427741,0.042799156,-0.013346415,0.060317393,-0.042704284,0.07776526,0.084123746,0.047779463,0.009086486,-0.03181564,0.040170252,-0.119232684,-0.0753011,0.008295258,0.10487768,0.012771022,-0.092886604,0.018373659,0.036699146,0.014343174,0.005393019,0.08006749,0.049380176,0.005775515,0.016188275,-0.06666372,-0.049003568,0.0822056,0.028702172,0.04897438,-0.024820494,0.014113249,0.028658535,0.049434595,-0.030764233,0.049760226,-0.044281486,0.04742834,0.009188481,-0.025153222,0.038089577,0.007935795,0.07418231,0.10163746,-0.0045453086,-0.0062538576,-0.089286245,-0.055190843,0.04809632,0.057599816,-0.079271756,-0.048115093,-0.0707018,-0.01164984,-0.0419664,-0.029306758,-0.036694337,-0.0745656,0.0323129,-0.017400457,-0.04775828,-0.07389403,0.017828569,-0.058810297,-0.106255285,0.022275507,-0.095671035,-0.023177344,0.037672,-0.0023512586,0.021579368,-0.041781828,0.0061332816,0.04064627,0.041870303,-4.6413935e-33,0.10939986,-0.11396811,0.14114785,-0.08981922,-0.062967435,0.060519014,-0.007494118,0.004369389,-0.04628879,-0.012950226,0.032322723,0.01570384,0.027846107,-0.017457442,0.00858937,0.06594238,0.07916663,0.1183168,0.047307424,-0.00026373944,0.03005027,0.1472794,-0.0062737367,-0.08194951,0.013017672,-0.013293365,-0.03566643,0.02185974,-0.01156125,0.0393407,0.05652735,-0.015975716,-0.021125684,-0.076790005,-0.020933265,-0.0026469678,0.0006107095,-0.052974727,0.020374123,0.058255967,0.052441336,0.012660755,-0.05428199,0.0497244,0.036038935,0.023342943,-0.12043975,0.009564045,0.031047458,-0.02587884,0.03382187,0.060011156,-0.054977268,0.010192567,0.053564746,0.031788483,0.008564036,-0.01980091,-0.034697328,-0.051460966,-0.049376037,-0.01730798,0.03881037,-0.03356707,0.03462325,0.080022976,0.018091714,0.023771,0.010289472,-0.022189463,0.06134553,0.008882597,-0.041358646,0.12473601,-0.068990335,-0.058052633,-0.10283899,-0.016809946,-0.035363212,-0.0036994396,-0.023917446,-0.017895246,-0.030829422,-0.019684682,0.016266009,-0.0918678,0.023430247,0.044459056,-0.050558534,0.02815839,-0.015302077,-0.0017490175,-0.076546736,0.015774349,0.04198857,-4.1638753e-08,0.00033542444,-0.0755538,0.0033124203,0.019789532,-0.06934825,0.0044454155,-0.043144293,-0.013561109,0.00826975,-0.0029172988,-0.021491872,0.107105374,-0.029086707,0.021800956,0.027964652,0.02705512,-0.011459369,0.027003108,-0.021676285,0.021114184,-0.038324848,-0.03588305,-0.073495425,0.030283203,-0.013306787,-0.07653726,0.019837128,0.06442201,0.058063056,-0.04395715,-0.035319883,0.07727104,0.05632168,-0.06233528,-0.07377075,0.06820757,-0.04452963,-0.012470294,-0.033544667,0.05517411,0.02338011,-0.046133004,-0.03811244,0.02561068,-0.0328572,0.014716794,0.051251996,0.012699555,-0.02801619,0.012601694,0.072479114,-0.006767845,0.05919663,0.015873004,-0.02266339,0.03103114,0.011528618,-0.089718856,-0.003806579,-0.049126897,0.05090422,-0.026434593,0.15617746,-0.08970558 +4.2.1.156,"Requires Mg2+. The enzyme, isolated from the bacteria Salmonella typhimurium and Polaromonas sp. JS666, also has activity with galactarate (cf. EC 4.2.1.42, galactarate dehydratase).",384,1.0,-0.042269185,-0.09111416,-0.04335999,0.009852196,0.048663598,-0.0035388926,-0.02823527,0.009530625,-0.043713283,-0.031342085,0.02442453,-0.037271723,-0.025376523,0.077586174,0.003155123,-0.01280768,0.027881414,0.024036415,0.053199027,0.028080963,0.1116263,0.007990159,-0.0049604136,0.0021838516,0.0495534,0.047619354,0.10689983,-0.04568307,-0.0060538985,-0.05040279,0.0066771945,-0.0037625988,0.12702237,-0.10380933,0.021844529,0.1145206,-0.021170527,-0.032440808,0.055191077,-0.023800319,0.0069894963,0.0033733028,0.083126515,-0.03478933,-0.02123394,-0.021561462,0.043880694,0.029252183,0.044062365,-0.01231308,-0.07421605,-0.07116309,-0.04338999,-0.02210132,0.07180313,0.013490709,-0.1005962,-0.090862714,-0.01778049,-0.044829402,0.04902826,0.0032240278,0.018245596,-0.01727679,0.027533678,-0.026112992,0.042047992,-0.036866084,0.031635072,-0.04033588,-0.0435658,-0.0012028324,-0.022546817,0.021577636,-0.09544196,0.041882057,0.05824089,-0.111917526,0.1110384,-0.015454954,-0.036833122,-0.047073174,0.05218936,0.0866655,0.03993252,-0.03596304,0.075069346,0.08107557,0.025447618,0.045009382,0.061170842,0.008210164,-0.0077097216,-0.04754742,-0.05350036,0.035308447,-0.07383178,-0.015184933,0.020575639,-0.030955356,-0.0012278724,0.022530813,-0.00017664817,-0.028537922,0.0063990895,0.006499498,-0.0046844203,0.05265009,0.048143353,0.04303439,0.041347925,-0.004156326,0.003969788,0.016326264,-0.037107,0.06238414,-0.00087274035,-0.0942091,-0.086589895,0.04112809,0.02227271,-0.036538508,0.025793752,0.04168911,-0.020815257,0.07763583,-0.0638093,1.9256592e-33,0.019971685,0.012162616,0.052112404,-0.023928348,0.016251994,0.011491406,-0.044028115,-0.049900606,-0.012317934,-0.024741847,-0.10104696,-0.012651029,0.020146161,0.04587257,0.0013144533,-0.007887319,0.016113363,-0.028085088,0.040292613,0.04624248,0.0003770233,0.07009487,0.015905794,-0.04462893,0.049863886,0.09654617,0.049970396,-0.02326623,0.10022884,0.024329877,0.046481412,-0.13656928,-0.09700207,0.072734416,0.11747222,0.02666255,-0.075090244,-0.05106003,-0.027929544,-0.008569691,0.0015776982,0.045610502,-0.05310075,0.03999512,0.028654423,-0.082489826,0.021433571,0.058401763,0.020611605,0.044202045,0.044767864,0.023847919,-0.005749135,-0.04411613,-0.032601584,0.021702513,-0.0231875,0.08340256,0.06559503,0.047181163,-0.01134553,0.07979926,-0.0086825695,0.057126928,0.09249121,0.04577728,-0.04170812,-0.054102104,-0.041610878,0.0010863798,-0.004030683,-0.08673348,0.040058155,0.039223943,-0.07081046,-0.033121113,-0.0016361584,-0.057440232,0.0166058,-0.04488181,-0.049078573,-0.03293143,0.05706618,-0.010605442,-0.09913294,0.045876782,-0.047831967,0.0017848717,0.014320952,0.04670109,0.014231724,-0.016699277,-0.0446659,0.042567134,-0.022181766,-2.6395435e-33,0.031229103,-0.040756717,0.038146224,-0.07988051,-0.10090968,0.087130755,0.042478245,-0.08837296,0.071873836,-0.009676457,0.04650356,0.029728146,-0.0124966735,-0.09581145,-0.028733868,0.003549221,0.049196724,0.09429244,-0.09996811,-0.06903737,-0.005321172,0.12548079,0.010419477,0.04117723,0.014806474,0.049991846,0.036557157,0.048227586,-0.008369224,0.039721165,0.0049678683,0.070392564,-0.03084368,-0.13757198,-0.06843159,0.0032923743,-0.01718096,-0.018172964,-0.014455313,0.027123893,-0.015305072,0.091413,0.041738883,0.11086558,0.0031633377,0.053844254,-0.02664231,0.02355771,0.031239986,-0.042048037,-0.04137148,-0.10639337,-0.010311702,-0.009336445,0.028390002,-0.033169456,0.011906626,0.02208887,0.008840551,-0.06700061,-0.008048419,-0.055236172,0.07600453,-0.10242129,0.03751157,0.0560823,0.019995099,0.014277593,0.017131032,0.02380675,0.019711718,0.056985892,0.025588863,0.020132856,-0.029145718,0.08654335,-0.08122884,-0.027532758,0.06689064,-0.08771343,0.0838533,0.05149996,-0.05236349,-0.026805008,0.03782776,-0.10907412,0.04415891,0.089571506,0.0010395877,0.015117445,-0.07214682,-0.050828554,-0.056735795,0.05387072,0.050068934,-3.330329e-08,0.013992893,-0.052825864,0.008026889,-0.08824917,-0.0022878794,0.06270263,-0.051719207,-0.03396447,0.11280937,-0.06999745,-0.0033705467,0.062386848,0.0206453,-0.010883147,-0.018420288,-0.011357065,0.030941164,0.0077466825,-0.072641544,-0.045468587,-0.042451788,-0.058201216,-0.09889569,0.017636536,0.034447342,-0.077102914,0.026385488,0.017818008,-0.0045534023,-0.038850784,-0.029541433,0.025436275,-0.036636934,-0.0218497,-0.060093645,0.0466899,-0.05594622,0.014371875,-0.015395855,0.021648055,0.0075514424,-0.01469311,-0.013813724,-0.016063884,-0.08477598,0.024005791,-0.05855636,0.018182749,-0.055770047,0.037220635,0.023583317,-0.049615607,-0.044867884,-0.031063326,-0.089425914,0.028645227,0.02418336,-0.10087698,-0.07054131,-0.07545382,0.03389247,-0.032858614,0.07657296,-0.02087665 +4.2.1.157,"The enzyme, isolated from the bacterium Peptoclostridium difficile, is involved in the reductive branch of L-leucine fermentation. It catalyses an alpha/beta-dehydration, which depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI. ",384,1.0,-0.04434283,0.0025363201,-0.09713499,0.031326003,0.098943874,0.026987132,-0.07636445,0.048018347,0.034519996,-0.00878435,0.010030762,-0.019202538,-0.001331081,0.041490633,-0.023349963,-0.011671213,-0.093132935,-0.011577681,-0.025671026,-0.073295556,0.06275382,0.011804792,-0.03826777,-0.0034788041,0.09037372,0.048797235,0.075843744,-0.02842486,-0.043403663,-0.083573215,0.065064155,-0.061280347,0.09482565,-0.04383529,0.06736926,0.07955845,-0.06503346,-0.0012761151,0.092807434,0.030529786,0.026305458,-0.010962855,-0.0044172434,-0.0007919963,-0.025146369,0.0014638171,-0.038928017,0.105468586,-0.0016800392,-0.013905602,0.0012796273,-0.029319102,0.00094486173,0.007190251,0.011138999,0.05548146,0.0028173304,-0.020525536,0.01184384,0.054590788,0.024215216,0.026355764,-0.051971454,0.008241552,-0.049376223,-0.087463476,0.03483396,-0.073436365,0.03633201,-0.069223315,-0.036191665,-0.10012499,-0.014186062,-0.036531948,0.06402531,-0.06922281,-0.003933052,0.023825727,-0.0008205299,-0.051761992,0.09762111,-0.018281315,0.004565797,0.06821923,0.04758173,-0.0041786847,0.033613782,-0.06365854,0.062416516,0.00073960825,-0.0077253915,-0.02845417,-0.06203207,-0.050897893,-0.021857753,0.018326618,0.012043738,-0.005297331,0.0036227887,-0.000287411,0.0072276797,0.04774362,-0.019774357,-0.08480495,-0.08332134,0.0075713783,0.024326572,0.09694067,0.053160924,-0.018724341,0.021964284,0.014694296,0.03356848,0.011053992,0.008216846,0.029864645,0.09183003,-0.09580232,-0.068773754,-0.05953721,0.02567482,-0.04263086,0.07829006,0.081908606,-0.05179364,0.028571645,-0.13735083,3.3657897e-33,0.06475113,-0.016513826,-0.03738277,-0.018732093,-0.0032626635,0.027115509,-0.09073239,0.031203065,0.0094038835,-0.05492531,-0.043012746,-0.09337298,0.032786503,0.003789911,-0.05134034,-0.04605536,-0.026824096,0.009040362,0.04032942,0.023162149,-0.0053676013,-0.00021013856,-0.017101027,-0.008084603,0.073513575,0.05907942,0.02427612,0.011386867,0.04737026,-0.002387606,0.0130198365,-0.110625274,-0.055953275,0.019452618,0.020087864,0.020373465,-0.09373816,-0.02527103,0.035121914,0.06159467,-0.0030899814,0.06230676,-0.0041920324,-0.059474558,0.013625664,0.03749901,-0.017528143,0.11213514,0.020515673,0.02586615,0.06483744,-0.045154247,0.13726473,-0.08221613,-0.06137926,0.06416102,-0.028982094,0.04030644,0.060291033,0.06498828,0.034106012,0.14134105,-0.07800228,0.07210852,0.00088928454,-0.026079534,-0.06932189,-0.04241189,0.028426347,0.039762367,-0.11041911,0.025012141,0.07144003,-0.0345675,-0.004361888,-0.033055335,-0.083083354,0.07439392,0.046195325,-0.001480673,0.008295242,-0.0468101,0.009996265,-0.04221159,-0.016871694,0.0016155564,-0.06998865,-0.08631909,-0.01331279,-0.004821653,-0.008890219,-0.06722793,-0.041174527,0.060519695,0.0860736,-3.9767183e-33,0.05847056,-0.117093526,0.07229923,-0.032292623,-0.009956416,0.06700977,-0.004742762,-0.047534827,0.037079155,-0.006090488,0.029475952,0.024167288,-0.0114568155,-0.064748175,0.10913295,0.018556478,-0.012704811,0.07925569,-0.023786576,0.055021226,0.02090768,0.07718154,0.049559318,-0.06858897,0.047993775,-0.004151004,0.046312027,0.09145493,0.10450564,-0.03503448,0.0126785515,0.026240503,-0.00801242,-0.11151488,-0.062295564,0.064788185,-0.10450235,0.0231068,0.015681963,-0.01631285,-0.014546656,0.039217412,-0.00993302,0.049713958,0.057805646,0.040242366,-0.04500027,-0.018433258,0.032001417,-0.04891975,0.0372283,-0.086460955,-0.008437014,0.022226414,0.0026283127,-0.0015634061,0.033268474,0.060097456,0.0044585033,-0.051608905,-0.062266726,-0.04408109,0.026059125,0.016595066,-0.0037349388,-0.018098854,-0.04747067,0.039076224,0.014701546,0.014303167,0.077767015,-0.023205288,-0.021622896,0.08656895,-0.04433482,0.028387519,-0.07869829,-0.051160976,-0.029399874,0.0037011935,-0.054327905,0.009237331,-0.06861874,-0.07035623,0.026450474,-0.11633221,0.023785317,0.08763662,0.020048724,0.03767314,-0.008731699,-0.015042545,-0.004671373,0.055519633,0.08243513,-4.115655e-08,0.0048572095,-0.05782449,0.034771767,-0.0027007607,0.04118177,-0.02250064,0.06988,-0.02456842,0.008999413,-0.072590865,-0.029033726,0.08932313,0.023001503,-0.0033025455,0.044222474,0.063422516,-0.05027784,0.0077000656,0.007380961,0.044695843,-0.00647614,-0.047426242,-0.06730368,0.034446824,0.012795564,-0.10891366,0.044290926,-0.009551349,-0.04084838,-0.061379753,0.056796465,0.08609948,0.017192746,-0.06229678,-0.060388446,0.0061447285,-0.06294283,-0.0057601053,-0.01775434,-0.0005515738,-0.0021774976,-0.023958018,-0.04019502,-0.0006997959,-0.09751855,0.020856345,-0.048065946,-0.014609206,-0.031288728,0.0075221863,0.0063442066,-0.018912159,-0.025036616,-0.0486481,-0.064234234,0.04382514,-0.019928792,-0.056073293,0.062555045,-0.07841645,0.03632306,0.018909397,0.16260566,-0.0010653054 +4.2.1.158,"The enzyme has been characterized from the bacterium Oceanobacillus iheyensis. cf. EC 4.2.1.42, galactarate dehydratase.",384,1.0,-0.06696478,-0.053886637,-0.075604334,-0.05006533,0.016282354,0.01096209,-0.0635329,0.05421704,-0.009318587,-0.044451628,0.021348566,-0.14293762,-0.04407582,0.022225562,-0.081877,0.042799473,-0.015198217,-0.05495656,0.03159015,0.02119666,0.14737035,0.04920461,-0.05816213,0.019351976,0.058016807,0.010590618,0.05028647,-0.029219989,-0.0774725,-0.07398278,0.005444833,-0.046037808,0.12595142,-0.021613553,0.0935743,0.056614045,-0.022734726,-0.0864145,0.093875505,0.0154243745,0.018106194,0.016562287,0.046286687,0.0015685841,-0.04217875,0.014745011,0.006441919,0.08016265,0.029052522,-0.0036528073,-0.061894733,-0.080323875,-0.03896499,-0.012500031,0.049662434,0.014529978,-0.010680279,-0.07268984,-0.02747522,-0.046135105,0.07557259,0.015068177,0.12112587,0.0075225323,0.0076497123,-0.03457177,0.042804275,-0.023666441,0.045326263,-0.0458839,-0.08535186,-0.04596922,-0.01831825,0.0618832,-0.04004012,-0.0046156305,0.007594408,-0.0083883265,0.061818376,-0.028454568,-0.014852002,-0.033908404,-0.0021496897,0.041876502,0.030283075,-0.08042054,0.049294244,-0.0036579587,0.03407011,0.03328138,0.018074164,-0.033069678,-0.03530016,-0.05343564,-0.09954281,0.019115204,-0.020320265,0.024584208,0.057088647,-0.05129327,0.013384978,-0.013950125,0.014558943,-0.083889164,-0.008107152,0.029000409,0.032333907,0.08026182,0.060205266,0.028033921,-0.045135017,-0.02399256,-0.023459641,0.03866379,0.0100292405,0.06644935,-0.0032177316,-0.023115944,-0.09037125,0.025660453,0.029443154,-0.032637592,0.094123684,0.015730249,-0.07962697,0.08510372,-0.102940865,4.941135e-34,0.050501432,-0.029349582,0.008928877,-0.044260968,0.049691036,-0.031172758,-0.060607724,0.035322707,-0.04577668,-0.058062248,-0.14238401,-0.027951296,0.034525312,0.033429686,-0.03468939,0.0016205341,-0.0021529964,-0.044042595,-0.028593034,0.065962516,0.04491351,0.04089202,-0.012906406,-0.05203927,0.057062384,0.007097461,0.025886226,-0.0049204417,0.08510444,0.030646842,0.009282901,-0.15102863,-0.0997003,-0.0072835837,0.09891117,-0.029335413,-0.022728525,-0.042924143,-0.014604882,-0.023469102,0.0359222,0.018491685,0.024773352,-0.020343868,0.051693838,-0.007003455,0.011794597,0.098212786,0.060783166,0.0024999413,0.024631904,-0.040466752,0.070261225,-0.027506137,-0.020715097,0.055846374,-0.029304283,0.08913275,0.0025823296,0.058573004,-0.01119462,0.13019237,-0.021819664,0.03634327,0.014725287,0.057472963,-0.0361585,-0.020487485,0.024196293,-0.004972716,-0.06598874,-0.06788884,0.043350294,0.029952832,-0.017057262,-0.046959,0.0031775427,-0.05457817,-0.023569062,-0.020662652,-0.006417162,0.025607537,0.03483926,-0.06836446,-0.036397405,0.014099408,-0.013922959,-0.010463852,0.01922182,0.06713594,0.013138693,-0.059643604,-0.044045173,-0.011522826,-0.034979504,-1.6789305e-33,0.064959176,-0.08731394,0.06271584,-0.033626746,0.009879622,0.07130217,0.03889577,0.010441169,0.039718397,-0.031639572,0.05411082,0.008207093,0.0016395417,-0.09618866,0.03336037,0.06497759,0.017974962,0.051626284,-0.03153201,-0.07396559,0.01119295,0.058018927,0.06367959,-0.058700945,-0.027127659,0.010770464,0.03849799,0.07931306,0.018222757,0.017707,0.001955268,0.07801768,-0.021765772,-0.103212334,-0.11820864,0.005131253,-0.08844634,-0.055694293,0.05260013,0.019823378,-0.019032175,0.037252888,-0.022271968,0.04927319,0.018749237,0.05917227,-0.073376834,0.003147438,0.018922439,-0.023897875,0.017225083,-0.064258255,0.052497976,0.045237612,-0.004180985,0.00037517786,0.024426825,0.053836305,-0.014699806,-0.0107515855,-0.0058832923,-0.039310623,0.094867714,-0.034039095,0.034200385,0.032131363,0.004170722,0.059732623,0.002373202,-0.0145525625,0.07135326,-0.025391478,-0.06826917,0.077844314,0.014385781,0.020067228,-0.15503645,-0.0198659,-0.009487545,-0.037140433,0.026769621,0.048797667,0.016579546,-0.01736552,0.022202814,-0.09018988,0.084672645,0.08313975,-0.0057085557,0.07256966,-0.068356775,-0.024872962,-0.1132117,0.044805683,0.068653405,-2.8097721e-08,0.056082293,-0.04362426,0.10234028,-0.019592756,0.03681389,0.025731532,-0.047052953,-0.002114011,0.06795026,-0.070803404,0.007242142,0.07514346,-0.0120935,0.0064924103,0.0044115316,-0.002761275,0.025518343,0.0022736453,-0.013104146,0.06240962,-0.012024976,0.0053835856,-0.107803084,0.008349119,0.026601607,-0.025472067,0.017021628,0.041420367,-0.05006891,-0.054592624,-0.029570838,0.07919806,-0.017379114,-0.05592216,-0.086964905,0.03391617,-0.10296527,-0.033890285,-0.046044677,0.05847304,0.033825435,-0.0010105149,-0.019310188,-0.011505134,0.010481216,0.022197368,-0.013904907,0.07396633,-0.039060317,0.00054285774,-0.0012108797,0.001594898,-0.050613932,-0.02590851,-0.086656064,0.012005158,-0.010699815,-0.11170167,-0.05635733,-0.0119996965,0.035177384,-0.025064534,0.1646572,-0.0023416975 +5.1.1.21,"A pyridoxal phosphate protein. The enzyme, characterized from the bacterium Lactobacillus buchneri, specifically catalyses racemization of nonpolar amino acids at the C-2 position.",384,0.99999994,-0.053529162,-0.08562185,-0.066992715,-0.06330405,0.019367846,0.06109501,-0.050002124,0.04878397,0.07708981,0.0040284386,0.0042980327,-0.049374584,-0.052985396,0.049003668,-0.030701214,0.013823162,-0.067398675,0.0481835,0.024297165,-0.031153552,0.09964186,0.042697724,0.014483009,0.036995437,0.004039945,0.06296642,0.06764213,0.011072434,-0.012423581,-0.01004886,-0.02901383,-0.07257882,0.004569959,-0.047574356,0.06417617,0.08955124,-0.062496856,-0.05776434,0.059328903,-0.03127035,0.0660989,-0.02561785,-0.019939594,0.0067656008,-0.05493405,0.026516637,0.10290144,0.059335377,0.014919901,-0.073997185,-0.11646539,-0.05130795,-0.07483998,-0.040088095,0.03048131,0.053807475,0.03970161,-0.026761863,0.012259999,-0.0501083,0.04801286,0.0051168166,0.053140145,0.048309255,0.031168304,-0.036376607,0.012824681,-0.08055248,-0.004960078,-0.021195767,-0.06422488,-0.050304916,0.08302446,0.030810324,0.0144141605,0.01692062,-0.06293303,-0.005092448,0.015941612,-0.02935295,0.02440803,-0.052194536,-0.056296125,0.09104902,0.022635024,-0.019027945,0.044329587,0.005224727,0.06609044,-0.042377707,-0.041709334,0.0454063,0.016528523,-0.04923769,-0.054279726,0.031208353,0.00289475,-0.026323892,0.04782203,-0.033762038,-0.0057318597,0.028230403,0.0093362145,-0.04367659,-0.09171538,-0.027955672,-0.07058699,0.05806601,0.0452791,0.0033279443,-0.04154271,0.059539102,-0.02658384,0.016959649,-0.013067112,0.04663782,0.08166063,-0.055373203,-0.0136920735,0.065265775,-0.007846622,-0.06303515,-0.01745194,0.08017406,-0.0571516,-0.00998526,-0.07914769,2.735918e-33,0.055974294,0.03121865,0.07361133,-0.021669252,-0.005021172,-0.029343503,-0.09182033,-0.04738719,-0.055075176,-0.012149733,-0.013174383,-0.041837625,0.03895484,0.063134894,0.018338924,-0.017509628,-0.05829762,0.06797226,0.091683984,0.015160094,0.014777915,0.110865235,-0.0007670554,0.08876036,0.04387579,0.07566856,-0.008938183,-0.04682703,-0.005591534,0.0009121829,0.027915178,-0.10305751,-0.13866128,-0.035703924,0.068006806,-0.08983937,-0.05353971,-0.06877049,-0.004769851,0.01741373,-0.070351094,-0.05982521,-0.019534247,0.017241802,0.017555775,-0.08706578,-0.02522575,0.069686785,-0.039913446,0.03507818,0.041336827,-0.046655223,0.078009255,-0.014571421,-0.091850474,-0.0068209446,-0.024916885,0.029795699,0.034108993,0.061687928,0.06872767,0.05176061,-0.051685568,0.015625797,-0.025488732,-0.051504288,0.0149574755,-0.052455503,0.11616938,0.09362937,-0.011830577,-0.0006005607,0.021824392,0.038281277,0.02313644,-0.053174987,-0.04760732,-0.013875486,0.004664937,0.039762255,-0.06849461,-0.0777592,-0.010702797,-0.08183974,-0.06467643,-0.0525681,-0.0460085,-0.05632618,-0.006842456,0.0075520515,0.016927853,-0.09303753,-0.0805398,0.060837004,-0.029123317,-4.6916793e-33,0.08909172,-0.11657626,0.059515435,-0.02737727,-0.07179334,-0.052286305,0.0423255,-0.0109597305,0.0011423742,-0.021792985,0.06585487,-0.025140176,0.08152536,-0.007555026,0.009304101,0.04882324,-0.018398298,0.032367762,0.055313036,0.05606205,0.062255256,0.038205028,0.012447941,0.040115334,0.041721318,0.06268422,-0.029608788,0.072686285,-0.04213526,0.01902369,0.010991039,0.029633274,0.005005594,-0.10660681,-0.08540544,0.026446396,-0.042597428,-0.024964515,0.047708742,0.013697914,0.06658003,0.08560461,0.021455055,0.0035983224,-0.041759513,0.021734286,-0.022617945,-0.009252693,0.0054779192,-0.09392393,0.016827596,0.07267556,0.048686106,-0.029936964,0.01255554,0.031207023,-0.077279285,0.0067229564,0.026848277,0.02829205,-0.0112625025,-0.08910294,0.04917372,0.08495295,0.030533316,0.06484542,-0.0008173043,-0.042931728,0.045069646,0.011660287,0.061720923,0.019871969,0.026938079,0.11186241,-0.07163175,-0.010609247,-0.055912696,0.0077966214,0.018816942,0.0065054363,-0.0013057359,-0.025913669,-0.0042068413,-0.044657215,0.020217335,-0.07787494,0.018631248,0.07020866,0.006327885,-0.015514206,0.004190659,-0.034854677,-0.008867215,0.09447501,0.07553723,-3.3750645e-08,0.053730097,-0.04898268,0.063120194,-0.007423105,0.036965672,-0.016237771,-0.034823067,-0.06111416,0.081305794,-0.052413203,0.004101371,0.012446196,-0.015642757,0.0068077995,0.04122571,0.093352444,-0.027914502,-0.042500988,0.017512113,-0.01754205,-0.04227417,0.018695697,-0.14647482,0.036148343,0.06789249,-0.00787224,-0.0015914566,0.01833298,-0.02770986,-0.04926653,0.00929861,0.022850044,0.01412284,-0.027459295,-0.03373234,0.09907022,-0.10015876,-0.025635436,-0.03279499,0.0035510852,-0.012476006,0.04303362,-0.02904641,-0.027713176,0.0024822925,0.0755836,-0.05857013,0.049428213,-0.051219255,-0.030081911,0.052409366,-0.0054809516,-0.089095704,-0.026253875,-0.120428614,0.053800426,0.009359689,-0.0531682,-0.03824462,-0.0819322,0.034195427,-0.0153786745,0.14017239,-0.07445331 +5.1.3.33,"The enzyme, characterized from the bacterium Actinomyces sp. Lu 9419, is involved in the biosynthesis of the antitumor agent cetoniacytone A. 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+5.1.3.34,"The enzyme, characterized from cyanobacteria, is involves in the biosynthesis of galactolipids found in their photosynthetic membranes.",384,1.0,-0.12208195,-0.02050569,-0.11402358,0.020233378,0.008784488,0.022386339,-0.05229054,0.055814732,0.016878264,-0.013071893,0.03984098,-0.08322333,-0.08543227,0.023280287,-0.021945242,0.070986874,-0.07393912,0.014242347,0.018742668,0.030681683,0.08058386,0.0028155793,-0.06779433,0.05226899,0.06413697,0.03136868,-0.009477368,-0.03816546,-0.044335797,-0.007577515,-0.046201732,-0.043736655,0.09263044,-0.03927813,0.08436864,0.0855526,-0.014991213,-0.07067997,0.04890062,-0.038752828,0.058471587,-0.010586497,-0.049332395,0.020335693,-0.019658374,0.015320558,0.036568172,0.045075588,-0.006786754,-0.04668886,-0.049322553,-0.04235519,-0.11598992,-0.0067947316,0.0122709535,0.043787137,-0.024426354,-0.091322236,0.0111044645,0.011483252,0.0671861,0.02200908,-0.0390684,0.06731604,-0.013073693,-0.100195505,-0.0008131255,-0.064385556,0.09306136,-0.07572336,-0.059317973,-0.08005158,-0.060019627,-0.0108785415,-0.033877384,0.019012038,0.063281156,-0.015695194,0.018690635,-0.028475177,0.088230066,-0.011103942,-0.007748845,0.06757129,0.063115805,-0.04956857,0.045690373,0.04220714,-0.013735889,0.010611782,0.046748705,-0.0074005495,-0.028608888,-0.07291185,-0.073308595,0.056056287,0.05527826,-0.055834662,0.08302524,-0.019520976,0.035457674,0.0074083796,0.038006496,-0.04661183,0.010678324,-0.0030937667,0.012855076,0.05457591,-0.02440951,0.0025422561,-0.0030189974,-0.0051655797,-0.0017612145,0.0039346423,0.00986819,0.07599285,-0.00032952626,-0.030897997,-0.030386122,0.11815969,-0.016729204,-0.023703663,0.02630577,0.033928342,-0.0117433695,0.0762199,-0.12606195,-3.6505436e-34,0.08945777,0.0050079264,0.033532932,-0.05154444,0.015294619,-0.007164562,-0.04831991,-0.0387997,-0.013144288,-0.054450106,-0.10096163,-0.0663002,0.023180028,0.009338601,-0.06227742,0.06241582,-0.057988264,-0.012793253,0.066932626,0.06938839,-0.044114873,0.03814031,-0.024099369,-0.024645219,0.03268114,0.02341821,-0.055643562,-0.004765713,0.057112634,-0.00643523,0.02955964,-0.120742105,-0.05481416,0.04175418,0.15358026,0.0029082678,0.024936201,-0.08919115,0.006093555,0.007131445,-0.07123059,0.010031221,-0.0041578473,-0.01967104,0.018367339,0.034429416,-0.08277194,0.038134344,0.053234268,-0.030812344,0.057899732,-0.029849565,0.061124407,0.0057696654,0.01367863,0.037070554,-0.039101075,0.077970654,-0.013439601,0.026543776,0.008562395,0.06575858,-0.042909842,0.070673585,0.10445983,0.051319808,-0.057345152,0.036426153,-0.042606898,0.04543655,-0.07853448,-0.061368495,0.043851532,0.0023213516,0.06570956,-0.0035706444,0.02460705,0.00089087593,-0.017135413,0.036598284,0.004837977,0.007518915,0.008197691,-0.06929672,-0.062332135,0.008832972,-0.024562526,-0.054194886,0.0076701846,0.029693939,-0.0025484294,-0.035199907,-0.04663598,0.028172875,-0.08190475,-2.9607953e-33,0.07999911,-0.09518207,0.07761681,-0.08182058,-0.0058835144,0.095571555,-0.07992513,-0.04562341,0.065490976,0.026120856,0.046077568,0.010607744,0.0055898037,-0.025661629,-0.027635934,0.046570554,0.011653906,0.06638866,-0.049216487,-0.0021256825,-0.043237027,0.068746075,0.027606856,0.014642894,-0.011016572,-0.044995375,-0.048182655,0.032653093,0.03210696,0.0063592545,-0.026943304,-0.024233343,-0.047483634,-0.08225833,-0.041685015,0.04597752,-0.04651234,0.008913636,0.07363746,0.07688897,0.023289032,-0.00058302784,0.02750047,0.02597564,0.066815995,0.014594478,-0.069847316,0.019040797,-0.039980944,-0.054704983,-0.029244494,-0.018850015,-0.023425138,0.079640575,-0.0038212168,0.059812613,0.063941896,0.05325915,0.056289025,-0.039038032,0.0044452217,-0.14384301,0.013638807,-0.06036693,0.032542888,0.0555825,-0.03898177,0.024394248,-0.011307944,0.0057361443,0.053273145,0.029747864,-0.038595725,0.0462325,-0.019149164,0.036651153,-0.060463995,-0.13047016,-0.03562142,-0.025669618,0.10596874,0.03796391,0.036245923,-0.04894072,-0.030267023,-0.043717258,0.081352316,0.06754726,-0.024406152,-0.037357327,-0.012549123,0.004948769,-0.044181865,0.06406635,0.04039043,-2.6895862e-08,0.06513559,-0.04105987,0.08314572,-0.08508259,-0.018000524,0.06625517,0.035936844,0.021311624,0.052514885,-0.047313448,-0.03396409,0.077124745,0.009569942,-0.04062199,0.051455565,0.055193458,-0.00122357,-0.018447703,0.01351947,0.015037986,-0.037510946,-0.033234492,-0.10064745,0.01799831,-0.03421407,-0.08360176,0.059646327,0.046733137,-0.03509092,-0.005085279,0.04434003,0.021476092,0.02074523,-0.0154734105,-0.096149646,0.0008647412,-0.055973865,-0.10904216,-0.014241726,0.024044957,-0.008816386,0.007370988,-0.04859349,-0.004512252,-0.060124256,0.02331794,0.026669465,0.06248478,-0.03392549,0.05929005,-0.039523732,-0.014346148,-0.052412596,-0.07659207,-0.049642224,-0.042981304,0.048768487,-0.030956676,-0.057215925,-0.014855385,-0.028580122,0.016690383,0.20363289,-0.013487719 +5.1.3.35,"The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose.",384,1.0,-0.10100799,-0.047182094,-0.2022907,0.0033196907,-0.01016488,0.046001144,-0.03627287,0.07312846,0.06661274,0.04272733,0.040805116,-0.013173644,-0.09600074,0.007918515,-0.078057714,0.03226919,-0.026342325,-0.06341192,-0.031073779,-0.089487515,0.049407985,0.03531907,-0.05863841,-0.02658096,-0.015143659,-0.051353198,0.0070529347,-0.07322998,-0.023693176,-0.047498412,0.02532339,-0.096843764,0.12173572,-0.0067224773,0.054610927,0.021560462,-0.06146661,-0.07151614,0.095009714,-0.033445887,0.0056837825,-0.04752637,0.006212102,0.025365075,-0.05374591,-0.0013413774,-0.0033765084,0.07194199,0.042399824,0.044555243,-0.028497288,-0.07354716,-0.08630773,-0.01782922,0.014329611,0.011899757,-0.028161308,-0.02141759,0.0132645555,0.04962967,0.054857675,0.016554972,-0.045899704,0.0646345,-0.115230046,-0.049315635,0.10751239,-0.053207543,-0.013233923,-0.037371885,-0.0037487326,-0.07960452,-0.029764812,-0.010011333,0.0039849565,0.032756478,0.004303033,0.022630168,0.006460099,-0.029168433,0.07731973,-0.04511763,0.09709417,0.10674273,0.010699029,-0.023673201,-0.00031786715,0.00063308945,0.09154093,0.015193848,0.02219719,-0.040331665,0.0069836653,-0.04482412,0.003943884,0.03990203,-0.021684084,-0.014114751,-0.02570924,-0.025827404,-0.009893146,0.05365701,0.03165747,-0.05990716,-0.09508961,0.007340254,0.004840976,0.08005537,0.029540604,0.035318512,-0.0749587,0.062684596,-0.019967187,0.0067128018,-0.0109407175,0.020143116,0.07674318,-0.035529412,-0.05862009,0.0039494797,0.015510698,0.014106991,0.038858507,0.04941617,-0.05479478,0.027174624,-0.06921546,-7.1327376e-34,0.035957903,0.015752269,-0.013288174,-0.05972871,0.049008187,-0.054486476,-0.061701555,-0.021190051,-0.016064674,0.030635692,-0.06155431,-0.10535006,0.037290655,0.04793641,0.035200834,0.045809604,0.04414879,-0.084881864,0.025067216,0.006602137,0.0016187141,0.056955785,-0.022032369,0.0018484576,0.03830518,0.060438182,-0.03568049,0.030254489,-0.00067334843,-0.00320432,-0.039480954,-0.05277903,-0.105397806,0.027885733,0.050610982,-0.04557457,-0.049428996,-0.060234148,0.012876839,0.033337537,0.028882094,0.010206641,-0.0050063087,-0.04009906,0.12043394,-0.03574284,-0.06662427,0.07564001,0.059828456,0.11698308,-0.0027325535,0.010717526,0.11828861,0.048729356,-0.03145823,0.033996146,-0.07435386,0.057949338,0.060962267,-0.014986715,0.055054683,0.072577596,0.00903358,0.0055662612,-0.049534455,0.01732642,-0.05187072,-0.077005036,-0.06447682,0.060439922,-0.008119118,-0.02541247,0.026833704,-0.009969771,0.04779449,-0.058409523,-0.01630524,-0.0035710514,-0.00027133562,-0.020492392,-0.00048333468,-0.00212561,0.059482057,-0.007929717,-0.07603339,-0.011105524,-0.0051776217,0.024699533,-0.06864769,-0.0022779661,0.034425173,-0.055689268,-0.10270322,0.10312967,0.029113036,-1.7424665e-33,0.11948601,-0.10951519,0.056997266,-0.1071245,-0.041346937,0.06658124,0.011083105,-0.010141492,-0.010218891,-0.015529536,0.010354388,0.06937415,0.012705284,-0.06340568,0.02613994,-0.03331812,-0.0062416606,0.032874957,-0.012864685,0.017403083,0.029774925,0.0853457,0.11273751,-0.04462676,0.051498298,-0.06906105,0.01757239,0.12443105,-0.018398594,0.03925166,-0.009718919,0.010784201,0.005746623,-0.09448445,-0.067312956,0.0131524075,-0.022899285,0.028759962,0.0150098065,-0.04658947,0.04840811,0.066405825,-0.00090434967,0.04722107,0.08321328,0.12681013,-0.057645783,-0.045154795,-0.0709444,-0.11874735,-0.0028164242,0.020167336,0.048963167,0.0073183454,0.08697053,0.047342815,0.010295751,-0.020471456,-0.033852305,-0.043999586,-0.051572382,-0.007880554,0.027444258,0.024199689,0.11505932,0.09505939,0.018933875,0.086956285,0.035320032,0.04351475,0.034570817,-0.016077379,-0.109114975,0.039404728,-0.01177641,-0.03052875,-0.03970869,-0.06814393,-0.0046751644,-0.036727868,-0.025865735,0.006911995,0.01554078,-0.009825942,-0.04784107,-0.05367497,0.031637046,0.04830778,0.021632167,0.08832179,-0.017925309,0.011316761,0.004447997,0.052316952,0.05000368,-3.040855e-08,0.059663165,0.011943812,0.053175416,-0.068669654,0.014354422,0.017220711,-0.057787444,-0.016442766,0.0096083665,0.028584644,-0.06769377,0.008309228,0.032622747,0.05844772,-0.03054722,0.030881925,-0.027561162,0.01739536,0.007378417,0.0102269165,-0.017320262,0.015590305,-0.039843895,0.020326765,0.005342149,-0.08171757,0.012840464,-0.022437582,-0.039834324,0.021628268,-0.09630548,0.08200759,0.01860588,-0.019318487,-0.06980704,0.009819835,0.018614504,-0.06264728,-0.0027156624,-0.011413106,0.004853925,-0.017536482,0.01865198,0.014758722,0.014090846,0.02724907,0.025051054,-0.04257555,0.0010062596,-0.01891745,0.07036246,0.04587167,-0.06820814,-0.02485068,-0.11567116,-0.026912633,-0.03995817,-0.08804837,0.019299198,-0.050308842,0.013861156,-0.03929322,0.07586871,-0.049398903 +5.1.99.7,"The enzyme, found in gammaproteobacteria, has almost no activity with 7,8-dihydroneopterin [2].",384,1.0,-0.057290554,-0.085909545,-0.04169738,-0.022542369,0.015596293,0.004379168,-0.009178062,0.08049795,0.0067955307,0.041295778,0.041570134,-0.07421205,-0.06193137,0.094226636,-0.056465734,0.06762201,-0.008102409,-0.0756863,-0.015588879,0.03553414,-0.008667011,0.00047142597,0.053485334,0.009851047,0.053525075,0.020358728,0.06127775,-0.07087247,-0.010703504,0.016820718,-0.03165015,-0.07218546,0.015936363,0.03814664,0.100573406,0.10655424,-0.0019817853,-0.07865515,0.016492257,0.022766598,0.040680192,0.051334515,-0.073155284,0.00032586706,0.01405161,-0.01792033,-0.04890578,0.0062519945,0.06713432,0.014906817,-0.024783421,-0.081019364,-0.015995396,0.051562123,0.014217228,0.025299514,-0.062801726,0.0030610913,0.011552984,0.10477253,0.061692666,0.009033414,0.053457327,-0.03562921,0.055502035,-0.046853233,-0.025232093,-0.014591032,0.0019945467,-0.06323425,-0.049374875,0.01715078,-0.06663577,0.055373475,-0.06664587,-0.0054788124,-0.009538049,-0.028458988,0.02378444,-0.07806534,0.0082379,-0.013203713,0.06537592,0.118042484,0.04572073,-0.032131404,0.039849993,0.098084584,0.06773869,0.036366995,-0.0024583128,0.054696426,-0.0026133764,-0.08353771,-0.04142045,0.063287616,-0.051322065,0.014418371,-0.054977484,0.047821168,-0.02748425,0.062771976,-0.019148653,-0.023039011,-0.08635761,0.02949384,-0.028674338,0.002972637,-0.021615341,-0.019617667,0.05733455,0.009560474,0.06681766,0.053605247,-0.018155789,0.042683728,0.017704137,-0.033428013,-0.08592371,0.040405154,-0.010928788,-0.035703983,0.11066609,0.07413081,-0.09560361,0.06350743,-0.06526592,-3.3495174e-34,0.038482394,0.001118862,0.03499561,0.0004480453,0.021782568,0.06784614,-0.034085497,0.05065398,0.021706073,-0.04076965,-0.06681163,-0.10680759,0.07578381,-0.041136045,0.041158397,0.021858688,0.06912011,0.005029558,0.04616495,-0.017411225,0.06429586,0.05535099,-0.019979205,-0.05534474,0.040975235,0.026679805,-0.090788655,0.037987318,0.098359644,-0.02480036,-0.044498734,-0.07889961,-0.053569328,0.06445274,0.045670882,-0.056455154,-0.03386158,-0.0867007,-0.03240592,0.012057512,-0.03934431,0.022502448,-0.020048285,-0.0632075,0.08378885,-0.048043396,0.026914166,-0.019736748,-0.047464337,0.021155717,0.015868753,0.022997394,0.052046474,-0.083180726,-0.0521256,-0.013990809,0.05234205,0.0046626613,0.07617753,0.030677196,0.05231518,0.028615406,-0.043443557,0.001254899,0.0006690379,-0.018472098,-0.056338876,-0.04598858,-0.026396526,0.043094266,-0.010801908,-0.03816334,0.0034260072,-0.015313794,0.029392269,-0.08539578,-0.08063366,-0.026755566,-0.03565503,-0.012323315,-0.014102085,-0.02891901,0.031117136,-0.0034160744,0.003651284,0.03701325,-0.0121835265,-0.07250614,0.002739109,-0.0068139965,0.06882503,-0.01061971,-0.14253238,0.0024632663,0.07063916,-3.966708e-34,0.025076061,-0.06819821,0.010608435,-0.07873247,-0.028766815,0.10645122,-0.023859726,-0.01088291,0.069646485,-0.04662043,0.1663232,0.01744155,-0.040672902,-0.061815728,0.0174464,0.08160619,-0.04496724,0.14345849,-0.008900028,-0.0030131605,0.038362086,0.05046011,-0.017063035,0.06827962,0.042387247,-0.0016416059,0.022595083,0.051964812,0.121968515,0.01824967,-0.033809822,0.0505638,-0.029007468,-0.07191698,-0.013302694,-0.007535136,-0.038227644,-0.05899266,0.015283566,0.011911363,0.020069467,0.007127148,0.032871578,0.062197555,-0.056086034,0.08993267,-0.022516362,0.032014877,0.0019244131,0.004552424,0.052456852,-0.09426589,-0.042493552,0.02065721,0.014489745,0.016351333,-0.003115549,0.022275066,-0.030845044,0.001137897,0.045395873,-0.04188092,-0.033980943,0.031657852,0.031525142,0.112988114,-0.07229878,0.1335733,0.014179026,-0.08144695,0.043992586,-0.06519937,-0.059035316,0.011222686,-0.004768169,-0.0011892134,-0.0170215,-0.014792077,0.09287662,-0.071797535,-0.02437618,0.02498825,-0.040817,-0.10374971,0.044335403,-0.053168986,0.024823215,0.053107556,-0.043966223,0.096030906,-0.01319753,-0.0068920064,-0.008044428,0.06158699,0.04684424,-2.5506376e-08,0.05684585,-0.06696542,0.061770156,-0.08247912,0.023210004,-0.060389385,0.029256374,0.0328424,0.01852607,0.009932809,0.0005656229,-0.02078389,-0.013766693,-0.0053853565,0.011901235,0.010372573,0.02320898,0.008746556,-0.04644941,0.020308156,0.0066989204,-0.02493656,-0.039220467,0.010063565,-0.05957251,-0.09915759,-0.015048787,0.04363581,-0.04393421,-0.054689623,0.01410428,0.02055571,0.006453827,-0.06694888,-0.10840556,0.06838074,0.020541498,-0.06914779,-0.038124107,-0.037222024,-0.03198441,-0.039674163,-0.054800376,-0.0019216931,0.001652564,0.030316781,0.007817647,-0.004836048,0.010603808,0.041756205,0.07286797,0.014560477,0.02615831,-0.07422815,-0.08408285,-0.0084403595,0.046676055,-0.08264241,-0.042234935,-0.06916311,0.092092946,-0.080064915,0.141945,-0.033124957 +5.3.3.19,"The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme can interconvert the (E) isomer formed in the reaction into the (Z) isomer [2], although this isomerization is not part of the pathway leading to bacilysin [3].",384,0.99999994,-0.07201472,-0.025849175,-0.07696515,0.022703355,0.03655457,0.00530097,-0.076024584,0.046413135,0.025196688,-0.008141754,0.033157945,-0.032414496,0.05476059,0.058158897,-0.08838536,0.0033854197,-0.10362557,0.009854222,-0.021201205,-0.016394252,0.03723035,0.08510794,-0.00032121415,0.0036538856,0.073134534,-0.0064155,0.048518702,-0.008749881,0.069894746,-0.053766668,0.020650974,-0.07815006,0.098596424,-0.14361164,0.048296124,-0.0339492,-0.010998023,-0.0016529912,0.1772352,0.031253975,-0.02785753,0.05141282,0.0016504806,-0.087275945,-0.013349149,0.03747194,0.037000153,-0.001955668,0.010864131,0.042620096,-0.034351096,-0.016426342,-0.035817448,0.010290929,0.008663315,-0.039924536,-0.101127446,-0.017231403,0.025862562,0.02062323,0.036332957,0.008207709,0.08530877,0.02212677,-0.038611185,-0.008867047,-0.004856689,-0.087934524,0.03880456,-0.06404828,-0.11426156,-0.068188965,-0.03264401,0.04714154,0.06012547,0.023712512,0.022436272,0.020828435,-0.0013436761,-0.014265233,0.03383138,-0.07232366,-0.0076977895,0.11875141,0.019564318,0.007641363,0.030722812,-0.00071255275,0.070002005,-0.024396552,0.030227773,-0.03821651,-0.012407055,-0.072691984,-0.030110674,0.0017406361,-0.06635938,0.03277094,-0.016012186,-0.017604005,-0.010124119,0.10319978,-0.044142272,-0.067885354,-0.02827735,-0.03888199,0.08205553,0.08021712,0.014351989,-0.024943277,0.06087667,0.017709542,0.036739837,-0.072442584,-0.0648725,0.052451044,0.05835774,-0.026781676,-0.037791364,-0.04993825,0.060165226,0.0088987965,0.010505842,0.052014638,0.025844956,0.027364573,-0.06170297,2.6600254e-33,0.030916616,0.09267389,0.004773757,-0.019870402,-0.021258583,-0.055231392,-0.0783881,0.017457666,-0.047009338,-0.015443058,-0.08763936,-0.07119778,0.055224236,0.09453898,0.04193729,0.022031607,0.059088517,-0.024559474,0.04440799,-0.034862187,0.005430548,0.03556565,-0.026957404,0.02814731,0.0654226,0.08872377,0.0818466,0.046477415,0.07033634,-0.027314393,0.025762115,-0.047270913,-0.11246455,0.011594672,0.09282481,-0.058915284,-0.044700287,0.016469052,0.04085898,0.096566774,0.036703408,0.060721472,-0.022488974,-0.022892172,0.07797365,-0.0076983245,-0.009574993,0.066103674,0.086353905,0.009609085,0.028446,-0.008622151,0.08653319,0.0010558268,-0.040743794,0.040568255,0.025933547,0.026737817,0.0009898682,0.047124866,-0.0052724304,0.045503374,-0.028696194,0.047391802,-0.021950722,0.062472288,-0.020749925,-0.028208463,-0.004959239,-0.0067069316,-0.08614051,-0.016205283,0.008584604,0.04414651,-0.057472564,-0.043334596,-0.07597229,-0.028562246,0.08069613,-0.026195213,-0.03606552,0.011620172,-0.030748256,-0.022717528,-0.015440555,-0.076643646,-0.049785,-0.052356403,0.0037667798,0.049061686,0.00030404926,-0.03739602,-0.048753753,0.07647323,-0.007909864,-3.9197362e-33,0.08162959,-0.09881947,0.03804114,-0.12223595,-0.12720534,-0.010957517,0.01583321,-0.060154695,0.0436289,0.0034109442,-0.0016314624,-0.026177425,0.033841506,-0.0150263775,-0.031619824,0.007570511,0.049674384,0.07143206,-0.015868261,-0.028815428,0.007960924,0.06697824,0.07578791,-0.09471548,0.052656546,0.070078634,0.038822487,0.09535769,0.046816662,0.031759497,-0.030869525,-0.031300426,-0.0050633424,-0.0976982,-0.11295762,0.11327082,0.00869417,-0.023362512,0.013209883,-0.091664456,-0.017321803,0.0011131845,-0.028766114,0.046654567,0.089020126,-0.0013450723,-0.043425053,-0.031847306,-0.012606003,-0.11277511,-0.032481685,0.008112317,0.08378591,-0.0052694366,0.0025670475,0.0061894353,-0.045364577,0.011318637,0.030835232,-0.0731099,0.026307406,-0.06973544,0.062638044,-0.008865809,0.03263544,0.0819394,-0.010206204,0.005245037,0.026385933,-0.10863273,0.06132913,-0.07136055,0.036457364,0.04981173,-0.05290828,0.017946107,-0.040843908,-0.07940923,-0.018145094,-0.056724835,-0.05594072,-0.041634835,-0.04725861,-0.018058538,-0.05951336,-0.040620938,-0.063576445,0.0846146,0.02876146,-0.014442397,-0.03368757,0.022651035,0.03140931,0.05824154,0.05569925,-4.2350383e-08,0.053764313,-0.042010605,-0.0047249077,-0.0437369,-0.040275674,0.057295553,-0.03942491,-0.08163768,-0.033921804,-0.0437581,-0.03641744,0.046656508,-0.04524305,-0.010393242,0.020755095,0.062480595,-0.07760375,0.0057734377,-0.0008232918,0.05296392,-0.03905886,-0.0068739057,-0.0909811,0.02607254,0.010933118,-0.08422661,0.017241044,-0.043532792,-0.03181336,-0.01413068,0.0034290524,0.026787063,0.018778285,-0.03880741,-0.05871822,-0.006105123,-0.07082914,0.019781074,-0.0033990366,0.0024415054,0.07001837,0.017077336,-0.11748357,0.019345712,0.0042470456,0.03538562,-0.0024324332,0.06743209,-0.020145038,-0.038058955,0.024528243,-0.035804503,0.012609331,-0.015690174,-0.10338682,0.025066072,-0.009391184,-0.025385592,0.03294675,0.010879446,-0.010583905,0.01622952,0.13624457,-0.007275579 +5.4.1.4,"The enzyme, characterized from the bacterium Agrobacterium fabrum strain C58, belongs to the amidohydrolase superfamily. It participates in the degradation of D-galacturonate.",384,1.0,-0.05532789,-0.13444129,-0.053167794,0.006225575,0.014262585,0.009207796,-0.0773457,0.07267568,0.054227,0.015050088,-0.0362856,-0.011985325,-0.016540123,-0.0019075376,-0.10866163,0.021611724,-0.083062656,-0.021100927,0.007424264,0.0034638732,0.107305735,0.053093962,-0.0012276975,-0.033813633,0.09655913,-0.032372013,0.029512048,-0.033865202,-0.04988774,-0.06921701,0.019034216,0.031224066,0.098549955,-0.010878426,0.03724273,0.12135811,-0.02483579,-0.029917538,0.056966584,-0.025923816,0.0003775934,0.0154261775,0.07027434,0.010820667,0.0032232052,0.063449256,-0.013484567,0.04651896,0.054559607,0.0007690934,-0.010897838,-0.0820715,-0.001160494,0.015221567,0.082510814,0.08348781,-0.021511938,-0.104297675,0.017079853,0.04747413,0.028833967,0.04385161,0.021733368,-0.022705859,0.00047928793,-0.046655625,0.01365255,-0.08631135,0.019208498,0.004597066,-0.09389464,-0.060800202,-0.003743574,-0.011820707,0.035997696,-0.02152089,-0.057266135,-0.043258216,0.11288233,-0.08055869,0.047076195,0.042061392,0.03135097,0.006055308,0.010284592,-0.041145075,0.10861823,-0.021214042,0.035220716,-0.020436727,0.003516583,-0.034740426,-0.05573458,-0.07789107,-0.0972931,0.0021067872,0.03617373,-0.036082037,0.021804601,-0.01256602,0.027975323,0.007138324,0.03454541,-0.089922726,-0.07688205,-0.02951566,-0.04217659,0.13308425,0.01852995,0.004629155,0.008877939,0.002621261,-0.015254246,-0.031095643,-0.039894212,0.02123075,0.044436146,-0.06779751,-0.07559509,-0.053647254,-0.04800024,-0.020790786,0.07356313,0.051065892,0.014431877,0.014610812,-0.1053517,-1.0329623e-34,0.068423614,-0.022803107,-0.06236144,-0.0712544,0.0045677735,-0.02242495,-0.080181316,0.017720051,0.03297873,-0.051506672,-0.03449359,-0.050361056,-0.013607965,-0.032709025,0.004750601,0.05025438,0.012002081,-0.018777618,-0.0131574115,-0.058175515,0.008181161,0.10812479,-0.020140737,0.02379446,0.068845406,0.026629822,0.042203914,0.025118092,0.12296229,-0.00037379866,0.013776982,-0.07399062,-0.11122629,-0.008616061,0.029416254,0.030299962,-0.059236422,-0.015965275,-0.013804525,0.045526974,0.036747243,0.027047576,0.0073542735,-0.038364917,0.047799215,-0.019599164,0.03074808,0.11161105,0.032889225,0.02887977,0.037726864,-0.04318674,0.09882569,0.0057393922,-0.05517085,0.039099302,-0.07258638,0.023779185,0.026372464,0.032663923,-0.0036290565,0.04413046,-0.01944888,0.065455385,-0.03625473,0.019975714,-0.03993325,0.03328525,0.017307913,0.080677435,-0.028010786,-0.04917761,0.016620515,0.06071022,-0.031196231,-0.04529816,-0.051925715,-0.022511763,0.014322101,-0.042395394,0.0057273046,0.027162366,0.0036620277,0.02424928,-0.021856219,-0.017233504,-0.024624495,-0.031713244,-0.034271944,0.025129093,0.009001804,-0.06394967,-0.040020194,0.12102298,0.030094188,-7.1073566e-34,0.07562612,-0.08023072,0.10582241,0.010683071,0.0045073736,0.05617721,0.022056676,0.030325364,-0.011606933,-0.07707281,0.029692076,0.033152692,0.016013153,-0.055491254,0.024922995,-0.06527626,-0.023512833,0.039467975,-0.09316688,0.028153175,-0.0104741035,0.05201478,0.00038305452,-0.0127800815,0.01996069,0.050696764,-0.03168189,0.104939036,0.036002617,0.04285151,0.04007294,0.04354844,-0.06180165,-0.06351744,-0.08769343,0.017748302,0.0054235854,-0.017893514,-0.043345902,0.022540785,0.04139377,0.07471671,0.0063337833,0.058275413,0.073406085,0.046281416,-0.037838373,0.03485089,0.04653823,-0.057168346,0.005881319,-0.057403676,0.020411331,-0.006421189,-0.022656802,0.0657463,0.040281776,0.05493829,-0.01498528,-0.017491916,-0.057186026,-0.07737392,0.09434189,0.011605004,0.06545531,0.019551827,0.017371058,0.116418935,-0.0014818346,-0.034146123,0.106850445,0.08229738,-0.037210457,0.05559423,0.031420063,0.039317004,-0.064673536,-0.01701496,0.0249424,-0.0131635135,0.037408136,0.02290088,-0.0008660595,0.015630994,-0.07078596,-0.010196117,0.07752116,0.11641959,-0.04447019,0.008678154,-0.0634547,-0.02040713,-0.07085497,0.06314843,0.05401928,-2.793752e-08,0.052323673,0.023185622,0.016919158,-0.118078746,0.03608468,-0.010335056,-0.020723423,0.053636566,0.013283301,-0.0712005,-0.05859749,0.08644141,-0.078067295,0.0074993977,-0.0030347146,-0.00046368936,-0.049805015,-0.009717845,-0.05512663,0.034656342,-0.04197163,-0.04959336,-0.09334862,0.043219168,-0.05440438,-0.05351261,0.059660774,0.07167728,-0.08107195,-0.027974386,-0.0052237203,0.078387946,-0.020814056,-0.009976966,-0.10244995,0.0362358,0.00044194557,-0.06194007,-0.00060313434,0.06403107,0.039584298,0.0010903924,-0.01111663,-0.007905304,-0.045359988,-0.014678095,0.014616559,0.020308027,-0.032169644,0.04000808,-0.011063138,-0.018993657,-0.08305298,-0.05665926,-0.10327746,-0.041666288,-0.023015996,-0.07801236,-0.02218285,-0.03937121,0.022701442,-0.08538361,0.16999741,0.0072366656 +5.4.99.63,"The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires adenosylcobalamin for activity.",384,1.0,-0.11998238,-0.05771329,-0.09757294,-0.02815309,0.015228086,0.05758156,-0.10222184,-0.0028094165,0.02732421,0.0013098383,0.04348588,-0.12047396,0.019546418,0.021209888,-0.009689207,0.044404306,-0.037016414,0.02031451,-0.011787768,-0.049556065,0.0019617253,0.045044787,-0.0892562,0.038845807,0.06996397,-0.008647553,0.06736948,-0.020792603,-0.069605656,-0.025780512,0.014808115,-0.02456729,0.0710601,-0.0005576993,0.0270088,0.13339527,0.008889559,-0.022360086,0.077524096,0.025591522,0.011205628,-0.02561026,0.0026938186,-0.009183793,-0.114681706,-0.019694066,-0.006809963,0.059612487,0.021812895,-0.02720614,-0.039542962,-0.026309682,-0.112488225,-0.0030844356,0.088523395,0.05184516,-0.049066618,-0.024898129,-0.006678837,-0.0012217592,0.041225467,-0.05144777,-0.017514274,0.085229866,0.006864191,-0.08557134,0.07446726,-0.04860951,-0.0021862462,-0.023952108,-0.047079947,-0.023860306,-0.0108999545,0.029151693,-0.0018669582,-0.015939549,0.009274483,-0.05716705,0.008779443,-0.024959486,-0.034945473,0.04413962,-0.04107461,0.052501235,0.04490453,-0.032652482,0.035365906,-0.010041528,0.004301458,0.06680404,0.039659433,-0.014840508,0.020786885,-0.09643026,-0.09810133,0.070877254,0.012050801,-0.048996847,0.027030012,-0.017261345,-0.026042867,0.08860679,-0.0015580845,-0.06947992,-0.046368256,-0.070576206,-0.05722962,0.08915141,-0.023405856,0.06318729,0.016906576,-0.016600998,-0.0043844027,-0.004667118,0.031365223,0.101420194,0.02493624,-0.09597755,-0.12439018,0.028852137,-0.06828471,-0.047376327,0.012149563,0.05865945,0.019241575,0.03430878,-0.062202487,1.4514311e-33,0.08143876,-0.015513952,0.011218288,0.0030028187,-0.0038506265,-0.016500175,-0.058960672,0.078252845,-0.028633012,-0.061408337,-0.019806309,-0.0030036625,0.05062011,0.023929885,-0.04906969,0.03469757,-0.047841687,-0.001316152,0.025187884,0.087778755,0.0115904845,-0.053237673,-0.02333646,0.023654636,-0.0195763,0.045199938,-0.009001091,0.018451246,0.05646976,0.01825027,-0.0081053935,-0.08416903,-0.07986829,-0.013461612,0.02406149,-0.058302052,-0.029118566,-0.017549373,0.017576022,0.07487773,0.04184019,0.01904074,-0.05529007,-0.02428847,0.055960394,0.02017002,-0.021253556,0.07899582,0.03568041,0.09777458,0.05758482,-0.037595414,0.15944596,-0.022905864,-0.03529443,0.033421606,-0.052687164,0.00076298055,-0.03728092,0.005792165,0.030977622,0.080604255,-0.0018931843,0.055635378,0.050454937,0.0114530455,-0.054569628,-0.11553405,0.02916989,0.003232616,-0.0071755466,-0.0198967,0.033506606,0.0700498,0.015714059,-0.050931238,-0.020079186,-0.025495969,0.051021833,-0.015567522,-0.03931009,0.012301957,0.011809897,-0.015993034,-0.02776336,-0.043556433,0.006736898,-0.033468712,-0.053900123,-0.01633653,0.10193817,-0.06272938,-0.04770789,0.00465291,0.021043887,-3.4464308e-33,0.15409051,-0.1462338,0.020851238,-0.13181324,-0.017885534,0.078495085,0.037452772,-0.0004227513,0.03850968,-0.0045514526,0.10189065,0.03167997,-0.018189011,0.020765949,0.022054302,-0.075376086,0.025202164,0.043878097,-0.022264961,0.039017648,-0.031949166,0.009208286,0.09081847,-0.010532753,0.065422304,1.9923737e-05,-0.069608666,0.07134932,-0.07794115,0.080494545,-0.018446479,0.033751264,-0.061168887,-0.037800383,-0.07770645,0.095665544,-0.048507985,0.037931114,-0.031206751,-0.0032165435,-0.029897727,0.07735426,-0.035520922,0.03057546,0.0070371465,0.035484735,-0.049087297,0.033392154,-0.0608467,-0.08402023,-0.012645492,0.036080856,0.00747414,0.043693524,-0.019156864,0.08110372,-0.045512464,0.022304825,0.02837817,-0.12264028,-0.10307681,-0.05262706,-0.04857954,0.0105340425,0.054599557,0.095610894,0.03242484,0.053681865,-0.0031771848,-0.017655807,0.07202552,-0.025848774,0.035004213,0.027973969,-0.03771669,-0.061522786,-0.059325516,-0.072182216,-0.052057054,0.0194949,-0.033132173,0.011004007,-0.035989895,-0.024163876,-0.038932066,-0.054684952,0.020219728,0.039823335,-0.011244075,0.056194663,-0.052752133,-0.005424647,-0.05094625,0.04997811,0.060710717,-3.3183706e-08,0.020019159,-0.04399657,0.058752906,-0.02583787,0.07874961,0.048335906,-0.024291497,-0.014200604,0.07887249,0.02413551,-0.014327256,0.08617265,0.046395134,0.059432775,0.053644266,0.01593457,-0.011207081,0.014882758,-0.034123685,-0.026539205,-0.09486155,-0.019017313,-0.083768494,0.054702803,0.07215804,-0.007343926,0.037881304,0.016588112,0.005422159,0.00081940787,0.020789688,-0.018277705,0.008454582,0.0056074783,-0.06806802,0.017459918,0.0015457363,0.013662359,-0.04144733,0.022356883,-0.00489209,0.006599024,-0.11204266,0.009448224,0.054018553,0.06092916,-0.059502143,0.034733836,0.022711998,-0.027432034,0.0047138906,0.014404955,-0.05326565,-0.039243475,-0.09899124,-0.022978997,-0.026563497,-0.08731298,-0.040990382,0.011865852,0.005975481,0.10302282,0.118555754,-0.049433887 +5.5.1.27,"The enzyme, characterized from the bacterium Agrobacterium fabrum strain C58, is involved in degradation of D-galacturonate and D-glucuronate. Activity with D-galactaro-1,4-lactone is 4-fold higher than with D-glucaro-1,4-lactone.",384,1.0,-0.028611703,-0.13402589,-0.0072306036,-0.022474745,0.0003258437,0.00095394615,-0.05653277,0.11716878,0.019152217,0.020393226,-0.06820195,0.019038705,-0.050429985,0.034541808,-0.08745673,0.033414803,-0.039681155,0.04073696,-0.043690983,0.052329786,0.1055064,-0.016651569,-0.006770707,-0.030957824,0.12739863,-0.02561741,0.01830883,-0.045131598,-0.042588506,-0.06433688,-0.00078490545,-0.007843669,0.11680471,0.01408473,0.015871175,0.090804756,0.0044796555,-0.025116168,0.07662639,-0.026877845,-0.0046988004,0.031023743,0.051075224,0.010757728,-0.02549598,0.054939218,-0.02897575,0.03772328,-0.004815574,-0.011755918,-0.009540771,-0.06427922,0.0033905196,0.01119836,0.054313317,0.07306573,-0.014450621,-0.08617464,0.012272253,0.033645827,0.08377331,0.019618103,0.013765547,0.008281847,0.0136558255,-0.043191385,0.053574014,-0.09053138,0.026914746,0.01099801,-0.048800822,-0.05133846,-0.016845893,-0.05606902,0.018991465,0.03088533,-0.027190207,-0.06110202,0.10554137,-0.07010664,0.08060182,0.012267335,0.038895167,0.028300079,4.9855986e-05,-0.027303554,0.090334535,-0.02195039,0.06393389,0.006694286,0.03293033,-0.0048647323,-0.064302415,-0.054757625,-0.0809197,0.01657726,0.027072305,-0.023151116,0.036711086,-0.0009172057,0.007844663,0.023889784,0.047833066,-0.053684022,-0.06374166,-0.009729025,-0.017615093,0.09380507,0.016460214,-0.0014415893,-0.003229229,0.011302177,-0.02562819,0.032515895,-0.11621186,0.030393848,0.0810151,-0.04432272,-0.10021533,0.0051226625,-0.03028477,-0.033772375,0.06592118,0.004559518,-0.008531759,0.011769938,-0.037390683,1.57731e-33,0.07474539,-0.03439091,-0.0225199,-0.10531827,0.039361224,-0.008395422,-0.13131373,0.0104322,0.01465857,-0.0015075863,-0.041834556,-0.032561857,0.003443458,0.016520193,-0.0025212432,0.08616001,0.0045911088,-0.04707642,0.020397052,-0.053701792,0.02610377,0.048061926,-0.03664546,0.060536053,0.082706854,0.04125665,0.064725466,0.05601534,0.04817149,0.005479846,-0.011781832,-0.11634884,-0.10576871,0.02748595,0.018201953,0.045097154,-0.09271824,-0.015178722,0.015255036,0.019782528,0.027958132,-0.0045331996,-0.007710025,-0.025361264,0.03710015,-0.029623972,0.011672138,0.09699483,0.006942332,0.0642917,0.043254003,-0.057555128,0.014977607,0.028258815,-0.015500039,0.030536084,-0.074665695,0.032744505,0.08772446,0.026790455,0.030335665,0.044309057,-0.0113944225,0.050629377,0.025823027,0.013737941,-0.064507835,0.018537752,0.0025116117,0.019008866,-0.02793033,-0.078707196,-0.007869713,0.023962025,-0.057297517,-0.034221098,-0.005407573,-0.03264126,0.008001658,-0.025064489,0.0067803105,-0.0025436904,0.008375449,-0.0057907524,-0.08394355,0.025142757,-0.044346858,-0.055464216,-0.026254175,0.017294403,-0.004024119,-0.055105258,-0.06056648,0.06384238,0.024117185,-2.4399073e-33,0.0371216,-0.052121535,0.12830164,0.022958534,-0.015236358,0.05714602,0.008216375,0.021371868,0.004013692,-0.05494275,0.030344779,0.01910902,-0.030078093,-0.037948973,0.014612641,0.0050402535,-0.02375106,0.021921944,-0.08737879,0.018013345,-0.010094649,0.109447755,-0.02565861,-0.0010157103,0.020538267,0.014889179,-0.024852583,0.055881314,0.026221553,0.064953156,0.07262029,0.05201353,-0.010315659,-0.01644554,-0.06506603,0.020132357,-0.010316115,0.023928069,-0.02248322,0.040725496,-0.00075639,0.0725669,0.03891505,0.01024195,0.069916785,0.058259986,-0.054951925,0.009072217,0.085139036,-0.055134486,0.036671422,-0.057522304,-0.0014676838,-0.018701844,0.015775025,0.08453533,0.08810516,0.021784615,-0.10467835,-0.010263864,-0.051031496,-0.07659583,0.103703685,-0.051926184,0.06917164,0.048714716,0.0102222245,0.11934825,-0.012378122,-0.011186507,0.09509112,0.085607134,-0.03027753,0.043955676,-0.028400438,0.046290003,-0.09839325,-0.0104757035,-0.021028457,-0.01713975,0.054073486,0.037103135,-0.019759787,0.0089323325,-0.049725007,-0.051805798,0.032491554,0.12832104,-0.025983136,0.019798087,-0.086680084,-0.007538296,-0.043367896,0.046925113,0.081114694,-3.5160618e-08,0.07292229,0.023150437,-0.0013263056,-0.08527045,0.021322703,-0.021018077,-0.027488798,0.040147588,0.043370448,-0.082209304,-0.09641399,0.12788898,-0.08256699,0.017208872,0.0013789504,0.00019994137,-0.07585998,-0.040703516,-0.06124298,0.024222458,-0.04740115,-0.049664464,-0.08043752,-0.0049139685,-0.062135767,-0.07262588,0.062585086,0.07073745,-0.07701968,-0.023647405,0.02848079,0.09003673,-0.022938889,-0.02433904,-0.096277855,-0.000570156,-0.03631672,-0.080470905,-0.03568116,0.08456362,0.038919266,-0.009616303,-0.025319038,0.022464331,-0.092268616,-0.048884384,-0.028187903,0.015752891,-0.051725097,0.046103667,0.028748276,0.012863335,-0.13211103,-0.03080471,-0.065707475,0.014995797,-0.0059083537,-0.05116237,-0.037858225,-0.057505846,-0.00037580144,-0.10721338,0.10025163,-0.03870917 +6.2.1.45,"Catalyses the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein. The two-step reaction consists of the ATP-dependent formation of an E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step.",384,0.99999994,-0.07495205,0.027314387,0.0123409955,0.048805073,0.0051451065,0.053407412,-0.021914246,0.023550367,0.038166687,-0.010014293,0.01758691,-0.010453573,0.015768956,-0.0034389226,-0.05741888,-0.04885969,-0.029168366,0.019090189,-0.013408741,-0.08690844,0.06230691,0.013339022,0.0048570023,-0.029250078,0.048321377,-0.0024525635,0.035878427,0.05635364,-0.0011555522,-0.10480072,-0.037611462,-0.08714789,-0.014530358,-0.039741185,-0.023061566,0.12569778,-0.040609397,-0.020978643,-0.023168541,-0.073613234,0.079843044,-0.020208932,0.0040864195,0.0802093,-0.06965965,-0.034562152,0.0060379626,0.040908325,0.07049328,0.053271458,0.0069229486,0.022559125,-0.012145385,-0.010830755,0.088968694,0.018610833,-0.06966742,0.07441385,0.0018527465,-0.051921412,0.015466405,-0.005371568,-0.0065783113,0.013670373,0.030395579,-0.07235599,0.06977385,-0.032110482,0.016044257,-0.008676881,-0.049211424,-0.015892014,-0.060925994,0.017650606,-0.021933662,0.07568723,-0.09225065,0.027094707,-0.02534681,0.0042270673,0.04303533,-0.011280428,0.09551062,-0.004969226,0.018880958,-0.031784214,0.0025486592,-0.018784784,0.046472196,0.0011999372,0.05343823,-0.011113414,-0.0020337186,0.009568228,-0.033642463,-0.020321956,0.03128555,0.03400623,-0.08041584,0.01433063,0.05543974,0.11057976,-0.0063131824,-0.023031143,0.025575923,0.0054951296,-0.019067293,0.06617513,0.044875365,0.032271877,-0.070185736,-0.019394219,0.016699275,-0.058527686,-0.027090663,0.092447236,-0.0033120916,-0.009800472,-0.023545064,-0.039997976,-0.005363797,0.010623723,-0.043823875,0.08079238,-0.011846586,-0.07753137,-0.09652571,4.439355e-33,0.13011263,0.006681949,0.06959913,0.043112632,-0.019437272,-0.019322382,-0.10863579,0.021479761,-0.039888974,-0.024019592,-0.0028374852,-0.030997599,0.061092705,0.00828966,-0.056379516,-0.11297885,-0.063420415,-0.03824293,0.117082305,-0.0064707985,-0.048538808,-0.05583808,-0.0016867202,-0.02674281,-0.025841039,0.0068337996,0.0064285146,0.094552465,-0.017001178,0.014039651,-0.049283214,-0.058423232,-0.12968735,-0.022189992,0.0004199348,-0.07433282,-0.051174097,-0.026925666,0.094184026,0.0710446,-0.01167142,0.0022818954,-0.014318194,-0.096379936,0.07035876,-0.052310906,-0.027763508,0.12378771,-0.014556582,0.045096472,0.090524524,-0.07751417,0.10868483,-0.03580396,-0.10028011,0.033145364,0.010651186,-0.0011797865,-0.039583113,0.04719294,0.057516526,0.02749653,-0.048301853,0.0029455929,0.005714147,0.10192744,-0.09601964,-0.038934078,-0.013943881,0.04979788,-0.04995801,-0.050653387,0.11738595,-0.03682661,-0.05054174,0.008544062,-0.06365455,0.04827072,0.021841241,0.05312015,-0.05581568,-0.01883042,-0.09766659,-0.0129897455,-0.026822623,-0.0005487255,-0.007110901,-0.088190794,-0.024538215,0.025276035,0.074536264,-0.014686564,-0.007706592,0.02218891,0.08011751,-6.2055295e-33,0.14867075,-0.05242599,0.08702983,-0.041583102,0.045414124,-0.012117725,0.037907638,-0.019814972,-0.021265775,-0.014463102,0.07201048,-0.0416605,-0.013198438,-0.0382929,0.0034943153,-0.021453714,0.0020715923,0.02751589,0.04111101,0.024571091,0.014139278,-0.0536921,-0.00900709,-0.0016122769,-0.013042477,0.01807527,0.006760074,0.059747152,0.030622425,0.028358249,-0.03974097,-0.0058848425,-0.096318886,0.029230302,-0.07169132,0.056917306,-0.05529006,0.032267522,0.037892368,-0.019517908,0.057584666,-0.004140026,-0.011918616,0.04090253,0.09532432,0.06600814,-0.014378847,-0.020127706,-0.11314391,-0.12208958,0.058391433,0.06464077,-0.080071546,0.040638644,-0.06945737,0.14854354,0.065033235,-0.0118549075,0.08516971,0.033850856,-0.013045243,0.03032367,-6.0321607e-05,-0.01208256,-0.043571156,-0.01443884,-0.014860618,0.018038686,0.059387386,0.025373014,0.06474096,-0.05169943,0.06656696,-0.025282247,0.07224774,0.05703102,-0.0044147396,-0.0069913603,-0.06772024,-0.020592485,-0.02882541,0.010099759,-0.07897097,-0.06412939,0.0064018387,-0.0052357987,0.005188261,0.08199319,-0.009755504,0.020571066,-0.042567328,0.004967642,0.007655165,0.053604223,0.026820684,-4.2837577e-08,0.0070654796,-0.06119108,0.022100626,-0.03293989,0.02467968,0.102799125,0.0046261633,0.03853712,-0.00077430316,-0.038259067,-0.013281826,0.016206358,0.026678694,0.0004829363,0.05924512,0.099455945,-0.037598584,0.040225223,-0.0019990222,-0.03830631,-0.07746459,-0.01881795,-0.09372421,0.05963762,-0.025825968,-0.025306204,0.04993026,0.046602417,-0.039531536,-0.016879136,0.045359958,0.030720148,-0.06401903,-0.042878795,-0.014070965,-0.0010199458,-0.03330496,-0.019116158,-0.0070460527,-0.064876296,-0.07547727,0.03093545,-0.078379326,0.039837733,0.060799923,0.054984126,0.04530554,0.101008825,-0.103798866,-0.003565259,0.0013185448,-0.02895679,-0.06434074,-0.118660845,-0.029138463,0.0002172893,-0.028366774,-0.07843736,0.019319687,-0.08333318,-0.005130702,-0.052261014,0.041653354,-0.04569209 +6.2.1.46,"This two-domain protein from the bacterium Pseudomonas syringae contains an adenylation domain (A domain) and a thiolation domain (T domain). It catalyses the adenylation of L-allo-isoleucine and its attachment to the T domain. The enzyme is involved in the biosynthesis of the toxin coronatine, which mimics the plant hormone jasmonic acid isoleucine. Coronatine promotes opening of the plant stomata allowing bacterial invasion, which is followed by bacterial growth in the apoplast, systemic susceptibility, and disease.",384,1.0,-0.035091285,-0.03077781,-0.09318793,0.030434221,0.024579518,0.045528553,-0.061068635,0.09325664,0.07949068,-0.02194363,0.09452749,-0.053233158,-0.024547888,0.020858599,-0.006841822,0.012362307,-0.10775617,-0.016474158,0.043648373,-0.021318076,0.072824895,0.12048875,-0.055298503,0.032675333,0.045206964,0.047726348,-0.03362663,-0.020700857,-0.037998565,-0.046723545,-0.029997665,-0.07642436,0.062654175,-0.037899107,0.048621375,0.026332112,0.014127149,-0.054890733,0.11892971,-0.008532436,0.0046354183,-0.0801557,0.008055916,-0.06013087,0.013348277,0.043052252,0.048890978,0.02784558,0.083904944,-0.038252547,0.018044196,-0.103413716,0.005393202,0.030596765,-0.06372033,0.09298716,0.011730639,0.051634144,0.022949584,-0.006753242,-0.01914376,-0.031538494,-0.009635568,0.06483572,0.0147463875,-0.09008846,-0.046255216,0.03973967,0.017288603,-0.009607418,0.007980424,-0.022393037,0.011711587,0.07642765,0.054719396,0.05115547,-0.09096548,0.0012208571,-0.024768386,-0.022961223,0.09738815,0.061651845,0.032885555,0.09279925,0.007544176,0.0065861368,0.019241385,0.0098574795,0.030300828,0.032195363,0.06547115,-0.052132737,-0.012965858,0.050079558,-0.11340295,0.03920688,0.056745887,-0.029511033,-0.031654462,-0.050608233,-0.012457785,0.017741868,-0.052381907,-0.009287849,0.05796828,-0.0034406844,-0.07899579,0.009642136,0.046160705,-0.10372215,-0.0006407939,0.0031619042,-0.01907596,-0.056967013,0.027727673,0.06585614,0.06498926,-0.0730137,-0.07222578,-0.10510702,-0.0005000808,-0.10056929,-0.01485193,0.06851266,0.020264369,-0.0019505054,-0.10009229,1.33399755e-33,0.09249841,0.069873035,0.018983146,0.0018889797,0.007089426,-0.03340453,-0.06967567,-0.010287979,-0.01801717,0.013218949,-0.11452265,-0.045905266,0.015089517,-0.024853004,0.020003267,0.010633021,-0.08688064,0.021965517,0.05065714,0.012169129,-0.018338107,0.053356424,-0.042117953,0.026913567,0.013774935,0.038109742,0.05650533,-0.05069384,-0.021280557,0.0010795199,-0.027732302,-0.08153522,-0.024066947,-0.0016752791,0.095235944,-0.030440532,-0.046308406,-0.018277653,0.013270246,0.076698825,0.019607574,0.027047599,-0.041097485,0.035005346,0.061431788,-0.021650042,-0.019469956,0.074973114,-0.026033353,0.105868176,0.04127443,-0.030609637,0.10961857,0.008934768,-0.041197825,-0.010879231,-0.012627474,-0.020299975,-0.04746342,0.026620518,0.05341393,-0.008616308,-0.07633689,0.04147335,-0.13211985,0.024520515,-0.0815631,-0.06571613,0.07253814,0.09291589,-0.046929944,-0.0178582,-0.03882103,0.008098657,-0.0048620002,-0.011299163,-0.06206667,0.11231066,-0.010325223,-0.0034074122,-0.05006753,-0.029103138,-0.010596565,0.010018893,-0.024248317,0.008279433,0.03432026,-0.034914706,-0.035189617,0.0035745131,0.08958631,0.06665482,0.020275397,0.059573326,-0.009025536,-1.4473002e-33,0.07349234,-0.10514829,0.049372677,-0.08515069,-0.041640628,0.08144375,-0.064591266,0.019879956,0.06068328,-0.039986007,0.039193235,0.0674472,-0.011861105,-0.031503994,0.05727271,-0.017174643,0.017829942,0.024008226,-0.14104545,-0.024807978,-0.025308367,0.045788508,-0.019687233,0.046505958,0.03684939,0.035189897,-0.05837142,0.012196182,0.09434704,0.055045556,0.05839549,0.0023642043,-0.03979252,0.019594127,-0.025040433,0.0063795103,-0.009279255,0.07949919,0.039878745,-0.02195865,0.021919817,-0.0166901,-0.0529288,0.026386032,-0.0037624475,0.08370551,-0.041699275,0.04392925,-0.014640248,-0.041353583,0.025272848,-0.08670015,0.06568157,0.03880883,-0.0019382202,-0.040474154,-0.011609653,-0.001146943,-0.054729216,-0.06545078,-0.019033493,-0.06170695,0.024353525,0.0045243767,-0.006982723,-0.012612193,0.044515375,0.033765722,-0.014052058,-0.037578225,0.08078508,0.049430225,-0.055190712,0.011038219,-0.098469466,-0.009647525,-0.039655816,-0.0903446,-0.05246178,0.004078416,-0.04452334,0.036935233,0.0322871,-0.09686187,-0.006290379,-0.01681856,0.042618483,0.07135472,-0.0052097933,0.068819,-0.020230588,0.039097413,8.514695e-05,0.018958554,0.042345654,-4.115969e-08,-0.015909655,-0.07425133,-0.040413752,-0.052152175,-0.04132995,0.022589028,-0.0044990527,0.041229274,0.057219483,-0.032658726,-0.0558307,0.11170408,0.012525322,-0.009105449,-0.02184939,0.016538886,-0.020313818,0.03869822,-0.012799289,0.0070722518,-0.09661971,-0.02694872,-0.062491737,-0.0324737,0.047360014,-0.041631788,0.0680834,0.029651737,0.10596644,-0.048599813,0.08445882,-0.028230207,0.02287103,-0.0054520206,-0.051253147,0.046682168,0.029579677,-0.05132171,-0.022007868,-0.03047381,0.023170063,-0.019782355,-0.07411593,0.0029138734,-0.050406817,-0.0137758525,0.029529065,0.051788636,0.02370011,0.023235826,0.047356952,-0.012886991,-0.009993615,-0.04845331,-0.12523805,0.024503848,0.01963214,-0.05260456,0.00013737848,-0.028055789,0.0005559913,-0.0049886513,0.20719174,0.044601597 +6.3.2.48,"The enzyme, characterized from the bacterium Bacillus subtilis, requires Mn2+ for activity. It shows strict substrate specificity toward L-arginine as the first (N-terminal) amino acid of the product. The second amino acid could be any standard protein-building amino acid except for L-proline. ",384,1.0,-0.05533004,-0.16585436,-0.06252157,-0.053796913,0.06266512,0.04090191,-0.027723655,0.0689596,-0.031802386,-0.009007988,0.04453926,-0.04971632,0.06563645,0.07585626,-0.0031953203,0.06328521,-0.07254335,-0.08851198,0.030809816,-0.026804334,0.09828606,0.05128907,-0.07580012,-0.08253671,0.06320215,-0.014007566,0.060668502,-0.062060494,0.013659109,-0.01423166,0.00070175563,-0.057669807,0.13126436,-0.07824463,0.09162605,0.039986182,-0.036397625,-0.016535481,0.056167867,0.010421972,-0.03655102,0.023902137,0.051143873,-0.087776065,-0.01691205,0.010680341,0.11074952,-0.06708561,-0.02475622,0.05626144,-0.027031528,-0.027394129,-0.02200534,0.02352696,-0.027067436,0.0011519066,-0.1506193,0.01033978,-0.02456553,0.017356945,0.004140242,0.013335027,0.02818995,-0.046311658,0.045537617,-0.014968644,-0.021420091,-0.06257073,0.052446075,0.028633274,-0.0015873256,-0.043678444,-0.063746616,0.067292884,0.017338188,-0.036703996,0.03147767,-0.009875391,0.02334343,-0.09879358,-0.0352379,0.007825605,0.029333193,0.10744266,0.043323718,0.056587692,0.026633492,0.054830648,0.014020706,-0.01548879,0.045766924,0.005479766,-0.030500537,0.02498065,0.0075472845,-0.004900458,-0.04581052,-0.016601628,-0.008530515,0.02880141,-0.014019258,0.053826552,-0.0035597447,-0.03597434,0.019064695,-0.04925571,0.053884998,0.07354979,0.0032911377,0.017953048,0.09757498,0.03663562,0.013824079,-0.021718748,0.003907418,0.016704185,0.09254624,-0.075789444,-0.057917725,-0.043891255,0.028721383,0.023369713,0.0380309,0.043860804,-0.05065616,0.07624582,-0.055900205,1.4564523e-33,0.04666028,-0.012866487,0.029878033,-0.01026986,-0.0067558684,0.018275125,-0.08489161,-0.004178776,0.06956707,-0.06106843,-0.09651472,-0.09587813,0.033886015,0.10845615,0.008794582,0.00297562,0.04462811,-0.036865655,0.08844128,0.018317703,-0.052748185,0.048972115,0.006837119,-0.0016601145,0.03687609,-0.0019164963,0.18723586,-0.021131653,0.011309686,-0.017750956,-0.01566219,-0.14569376,-0.07406307,0.0028306455,0.051932473,-0.024125565,-0.025405651,0.011960787,0.009114466,0.016758483,0.008388325,0.10010192,-0.04317778,0.02717415,0.06702541,-0.042835817,-0.024564957,0.083743334,-0.06643708,0.017722515,0.025968192,0.0312339,0.06478526,-0.030752666,-0.03999514,0.016894935,0.0007652579,0.09158572,0.05233731,0.08454254,-0.006851648,0.028498786,0.039522678,0.13634202,-0.025961602,0.025100537,-0.07223154,-0.07394752,0.030961392,0.031941656,-0.06633155,-0.062911116,0.09637569,0.0014433346,-0.027749714,-0.07864597,-0.07367729,-0.0324907,0.06584515,0.012954282,-0.029325247,-0.02581457,0.02917513,-0.0012971391,-0.09802336,-0.05835054,0.009292565,-0.10239804,0.017441064,0.005544937,0.0038368355,-0.009030086,-0.07246447,0.084665366,0.008286544,-1.6027952e-33,0.058171514,-0.0518988,0.0396382,-0.103585705,-0.11213299,0.01685156,0.04745432,-0.1084961,0.019188795,0.031312197,0.08704705,0.037755515,-0.0031504917,0.008286579,0.02681029,0.0018840379,-0.0050397413,0.0724745,0.07693183,-0.01726036,-0.01697299,0.07514351,-0.001541308,-0.040948853,0.015179122,0.061318506,-0.04844958,0.10378739,-0.009434389,-0.0208631,-0.02236397,-0.005730366,0.011316741,-0.082054146,-0.036922228,0.052889917,0.013140507,-0.025953941,-0.00792215,-0.05234863,0.019029027,0.03601546,-0.0006718538,0.05319495,-0.02733235,-0.040279996,0.01632995,-0.05646438,-0.049916085,-0.10737037,-0.030713664,-0.092584684,0.023602637,-0.088144064,-0.0017586674,-0.018901357,-0.063062966,0.070767894,0.011548579,-0.02184504,-0.0062988643,-0.080382675,0.02225015,0.0047491444,0.012089496,0.05309055,0.012680715,0.0061788084,0.013483133,-0.030542158,0.04902524,0.0126258,0.08029094,0.074842095,-0.03944002,-0.026576588,-0.047578175,-0.018569672,0.02981456,-0.074013576,-0.023423105,-0.035272866,-0.04297633,-0.0022882202,0.00394622,-0.018443158,0.0066188406,0.08932257,0.026591433,0.012174834,-0.020751746,-0.03513596,-0.053429406,0.059025183,0.05781265,-3.4301355e-08,0.03327752,-0.041269008,0.0061981673,-0.025851151,-0.03648279,0.028119765,-0.03242508,-0.052932467,0.055996407,-0.03154138,-0.0063050203,0.046523515,-0.07393979,-0.0054283245,0.0091872895,0.051496293,-0.033558715,0.010948224,-0.05240109,0.0390282,-0.035225306,0.05506879,-0.10048105,0.017759364,-0.031186882,-0.04487432,-0.009094392,0.05496706,0.00044989216,-0.051573854,0.016566835,0.044811413,0.016232241,-0.050568886,-0.02967588,0.04033194,-0.014106681,0.011374222,-0.0031273714,0.024023132,-0.02151533,0.038532913,-0.043145336,-0.008295703,0.03125389,-0.0012840526,-0.06629084,0.027846983,-0.050474018,-0.01625226,0.036638122,-0.06943362,0.04965057,-0.046450578,-0.08345094,0.06062617,-0.07148141,-0.06016492,-0.020725602,0.0016179538,0.021115713,0.049929127,0.113521196,-0.035026707 +6.3.2.49,"The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme requires Mg2+ or Mn2+ for activity, and has a broad substrate specificity in vitro 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+1.1.1.389,"The enzyme, characterized from agarose-degrading bacteria, is involved in a degradation pathway for 3,6-anhydro-alpha-L-galactopyranose, a major component of the polysaccharides of red macroalgae.",384,1.0,-0.013720057,-0.11615172,-0.064572394,0.0044917683,0.014648803,0.03207408,-0.008389532,0.029440818,0.028442098,0.0026758905,-0.044861626,0.025639717,-0.09064995,0.018046632,-0.07341028,0.061461013,-0.04560462,0.02495205,-0.06681268,-0.006863659,0.12735486,-0.06423993,-0.10231906,0.018257817,0.08168091,-0.07979349,0.014899722,-0.054892063,-0.099241816,-0.09080148,-0.017711645,-0.019751385,0.15489763,0.0019234046,0.036504883,0.1129231,-0.00014265742,-0.09152158,0.06197385,-0.058844227,0.012885426,0.03539127,0.041338444,-0.043828208,-0.0024013324,0.013311407,-0.03345236,0.033866715,0.08306474,-0.034730364,-0.040681697,-0.073468834,-0.062872574,0.00025755618,0.04250889,0.07379734,0.036157213,-0.119026326,0.012860032,0.02369777,0.07052048,0.027976232,-0.03000308,0.04059075,-0.078566685,-0.06511428,0.05867688,-0.06516329,-0.06689696,0.05821698,-0.12573828,-0.056264635,-0.06548335,0.0017025447,0.034433536,0.031763524,-0.0005730798,-0.040343016,-0.017953407,-0.05323848,0.07575927,0.020578219,0.029249305,0.028733578,-0.03600532,-0.059309714,0.053759195,0.0021122121,0.054092888,-0.008788133,0.0044006547,0.05178594,0.030674595,-0.045417152,-0.021620575,0.027391523,0.017080117,-0.07247429,0.08875295,0.0073972284,-0.020034993,-0.01420099,0.062250696,-0.046829846,-0.08479908,0.053389594,-0.037095156,0.07235173,0.06403909,0.060039252,0.0067870836,0.016164957,0.017062552,-0.026897099,-0.087082274,0.06302817,0.042324644,-0.033139575,-0.039704427,0.015866391,0.06804187,-0.029057518,0.0875533,0.029774379,0.018189725,0.009197441,-0.05345855,-1.0062481e-33,0.037422296,-0.036178283,0.026819518,-0.022671469,0.08691521,-0.0060733575,-0.05227896,-0.0459094,0.03034479,0.014066539,-0.064703286,-0.032212984,-0.029212074,0.023840386,0.012989457,0.12978481,0.03003502,-0.011693185,-0.037197504,0.056525607,-0.033976812,0.052756887,-0.0041069495,-0.040334143,0.07511884,0.031860773,0.016462626,0.0052722646,0.032680266,-0.022712301,0.051077187,-0.03677791,-0.14895763,0.082037285,0.0892514,0.005302807,-0.06994379,-0.01871697,0.017188277,0.03344141,0.036607545,0.033569492,-0.01567458,0.0044003935,0.062097337,-0.037506387,-0.016980147,0.058042966,0.03291141,0.06920174,0.01921839,-0.057564322,0.029650267,0.056191258,-0.038181443,0.04332919,-0.0740717,0.042733774,0.030809913,0.014011266,0.034165885,0.032931164,0.005213859,0.016534407,0.020538233,0.02254022,-0.04270635,0.039142147,0.020400926,0.0155722685,-0.081224844,-0.026745068,-0.01875795,0.009583021,-0.031149773,-0.07480898,-0.049527355,0.029060941,0.021990996,-0.043155074,-0.004674986,-0.00905836,0.02870551,0.017947217,-0.08700162,0.018055012,-0.0117846,0.03353767,0.0008261112,0.008858219,0.03982649,-0.06331084,-0.1014693,0.047877464,0.012151245,-1.4705896e-33,0.08275321,-0.0539371,0.05925168,-0.010900766,-0.021673968,-0.005292618,0.0035024963,0.020340526,-0.042749025,-0.047854003,0.008284974,0.07809367,-0.016423877,-0.06796186,0.05641492,0.0066035427,0.04904554,0.072930396,-0.100241035,-0.0075295153,-0.032064706,0.07374377,0.041131858,-0.010548799,0.022570543,-0.062441647,-0.0117739,0.08163324,0.021536963,0.020767372,0.039033607,0.034166623,-0.0026486784,-0.08807172,-0.028361004,0.0019605444,-0.04722549,-0.013808657,0.037124567,0.043965984,0.049974784,0.059406083,0.018763244,-0.0041539907,0.09326533,0.073572986,-0.1229538,0.05671714,0.048439126,-0.05739371,0.016860249,-0.09643457,0.054197583,0.019308738,0.01754349,0.025325898,0.07978456,0.019508053,-0.016070353,-0.012923989,-0.05755852,-0.029325735,0.08642887,-0.035489257,0.048232727,0.024898617,-0.016632838,0.04636083,-0.0021262856,0.04452504,0.09090262,0.029149445,-0.10429102,0.058799542,-0.033765297,-0.011901657,-0.09415634,-0.02755846,0.013064859,0.016157964,0.021803794,0.011965948,0.02637992,-0.03939307,-0.0015220895,-0.09384105,0.05871917,0.08257439,-0.028762965,-0.0026431838,-0.014391182,-0.0312713,-0.04309112,0.023358071,0.01590781,-3.0075963e-08,0.08570894,-0.018675998,-0.052688118,-0.074650794,0.0034625004,-0.024568915,-0.01785055,0.048144754,0.056246407,-0.047035344,-0.044283785,0.090552524,0.008606396,0.013587511,-0.024309887,0.0069798483,-0.015692446,-0.04600792,-0.023165181,0.060252476,-0.0635482,-0.0015286236,-0.13710757,0.0075311777,0.017940648,-0.076855086,0.04223817,0.056685206,-0.031627234,-0.006067762,0.04188869,0.07765395,0.038644742,-0.018463552,-0.061616495,0.0023063885,-0.036491737,-0.06529246,0.069278374,-0.016430948,0.013893581,-0.029448206,0.0068954485,-0.0649203,-0.07192219,0.017145151,-0.040365376,-0.01271028,-0.03684633,0.038673036,0.053028986,-0.011437041,-0.11163623,-0.04097428,-0.06483711,-0.099376716,0.046738837,-0.020391654,0.006876867,-0.052017502,0.011113612,-0.06810919,0.12546152,-0.03650291 +1.1.1.390,"The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway. Activity with NADP+ is only 4% of that with NAD+.",384,1.0,-0.06219984,-0.031650107,-0.05670335,-0.011238025,0.031126462,0.088333584,-0.069732666,0.05414756,0.024254788,-0.0100715235,0.0060779485,0.04832649,-0.058250483,0.116067685,-0.06372971,0.10296164,-0.034684822,0.0326508,0.022624746,0.023821974,0.033974312,0.030602468,-0.016907867,0.008724332,0.09704582,0.057274394,-0.006259688,0.0017246477,-0.03482267,0.033368543,-0.026196085,-0.002134423,0.009833111,-0.08986889,-0.0068514855,0.082026504,-0.01737022,-0.03775976,0.034107026,-0.05766329,0.0020039505,0.004696746,-0.098008946,3.626113e-05,0.0014040938,-0.029508447,0.038896736,0.07416642,0.06391198,-0.061799236,-0.068830565,-0.0059080673,0.0214168,0.028196959,0.034044012,0.027334098,0.030481638,-0.0020070868,-0.034265094,-0.056227043,-0.00368104,-0.0614062,0.01176933,0.023064386,0.035673197,-0.0057211127,0.068036154,-0.018647695,-0.028250974,0.0029469242,-0.14525469,-0.0132918125,0.018976366,0.014178989,-0.026659349,0.0309159,-0.05670932,-0.048145436,0.07210938,-0.048806813,0.04290994,-0.006790089,-0.023209067,0.08199867,0.028443074,-0.017384576,0.06775359,-0.019866612,0.02609914,-0.017900076,-0.029575607,-0.03316233,-0.041554797,-0.021326283,-0.0987518,0.021878596,-0.013865025,0.014847412,-0.0039905477,-0.026654826,0.028840046,0.07115567,-0.011846932,-0.13788474,-0.044934053,0.016441315,0.010491543,0.112081185,-0.01060208,0.06251609,-0.01362828,-0.02743469,-0.0044200397,-0.024020154,-0.005608084,0.10746209,0.043671194,-0.0025670014,-0.14418319,-0.005073547,-0.02269815,-0.043746136,0.019004377,0.025930744,-0.01248096,0.014987074,-0.10618887,2.455078e-34,0.11950487,0.010469971,0.005996277,-0.037047837,0.06127837,0.010509023,-0.09276386,0.06754981,0.029046958,-0.027141286,-0.014352156,-0.13783538,-0.004722933,-0.015632235,0.015361334,0.029247887,-0.028770326,-0.044850156,0.04852495,-0.016856639,0.012190266,0.055722225,-0.035287794,-0.004323737,0.085104376,0.06811532,-0.0005641424,0.01889233,-0.07968532,-0.011246704,0.09751715,-0.07122887,-0.21594861,-0.05050321,0.0852619,-0.0045147333,-0.02336991,-0.037458573,0.001504776,0.06329655,-0.055537645,0.06495793,-0.0019849846,-0.05675283,0.058272216,-0.112004146,-0.011134958,0.15411928,0.03451419,0.09443938,-0.0229301,-0.07409087,0.07374673,0.014379427,-0.021152252,-0.00020890773,0.0013854038,0.0046439767,0.008333672,0.03330256,0.057297245,-0.005098056,-0.035413317,-0.0076449476,-0.04653842,0.012050083,-0.08265897,-0.005798567,0.06307034,0.02824147,-0.022765685,0.051014148,-0.023104545,0.032095965,-0.022368716,-0.077485,0.011401697,0.03754042,0.06215356,0.03498036,-0.06293129,-0.10756045,-0.025777252,-0.064810656,-0.07425137,0.061108787,0.030978464,-0.025194509,-0.06630321,-0.009046824,0.0830658,-0.05595151,-0.010075466,0.012176407,0.019931987,-1.8130944e-33,0.011817373,-0.020875301,0.07472006,-0.08638715,-0.016355397,0.051490728,-0.04172538,-0.013874455,-0.039202545,-0.035442762,-0.0052299346,0.04424337,0.05803651,-0.030135188,0.016314534,0.0051724506,-0.01621542,0.004584503,-0.028086286,-0.009620502,-0.007361404,0.110887006,0.00313884,0.0133845275,0.05848413,0.011863891,-0.039113715,0.07729754,0.07149892,0.08208302,0.039707698,0.04057937,-0.11564619,-0.020913944,0.024434114,0.00798906,-0.037392005,0.020139258,0.029586438,0.03395452,0.0917917,0.019392246,-0.05706618,0.079376295,0.0077329264,0.038684774,-0.0953528,-0.007049965,0.044578712,-0.12775667,0.06261012,0.05115274,-0.019047726,0.03909612,0.07609808,0.04488044,-0.0070247576,0.020795925,-0.04611153,-0.03676745,-0.046105113,-0.04064764,0.00233665,0.010721223,0.04356178,0.014338997,0.007256598,0.020826947,0.019813774,-0.04480792,0.037666824,0.009680946,-0.018429736,0.012443614,-0.06934742,-0.018805003,-0.10407368,0.02583395,0.0016165397,0.025805015,0.024994304,-0.019624405,-0.04620906,-0.11306628,0.015610417,-0.03131906,-0.012125006,0.07737752,-0.067287855,0.00043116146,-0.014690989,0.082707636,-0.06584162,0.024223657,-0.030290853,-2.6337528e-08,0.050913747,-0.016685648,0.061357804,-0.016209025,0.0018867112,0.025808392,-0.0015870637,0.03671277,0.03275257,0.027416037,-0.028761873,0.09948035,-0.00045422767,0.0018465383,0.046092574,-0.029803114,-0.042173214,0.00017394937,-0.0448216,-0.057453517,-0.054740388,-0.0601628,-0.10858214,0.06553259,0.017703697,-0.05047983,0.059277385,-0.0058188685,0.038503084,-0.062746264,0.00062651077,0.0120129455,0.031607408,-0.0011877813,-0.044174317,0.06033653,0.0009573746,0.0028085078,-0.03431965,0.08600321,-0.0241097,-0.07957306,-0.06643083,0.005252513,0.036740657,0.036980655,0.0900479,-0.024089092,-0.08641684,-0.058392517,0.08367872,-0.019786337,0.021395328,-0.030013157,-0.096454084,0.05131216,0.023196405,-0.00060747826,-0.0061321897,0.0337538,-0.026972901,-0.040588677,0.068800464,-0.008530278 +1.2.1.96,"Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).",384,1.0,0.018519767,-0.027055167,-0.060843475,-0.010354521,0.10443616,0.045076303,-0.06355918,0.007801003,-0.0029191966,-0.0024961296,-0.014611383,-0.019970162,-0.039736465,0.0742101,-0.076779164,0.074061476,-0.06957884,0.02417222,-0.039587032,0.018454103,0.047610138,0.025638167,-0.025714552,0.04018809,0.063059196,0.02212461,0.017595224,-0.03294292,-0.045390293,0.0068247323,-0.04395269,0.05402987,0.06349262,-0.068488754,0.041237608,0.12342419,-0.011614904,-0.01804915,0.06039596,0.022311073,0.013173967,-0.035453405,-0.07185474,-0.05199004,-0.044428024,0.019104017,-0.013231913,0.038090803,0.051578935,-0.054923974,-0.026738722,0.00727498,0.073003635,-0.029617207,0.010391946,-0.008076249,0.049545504,-0.016204057,-0.09550813,0.024066562,0.034953777,-0.0767965,-0.039631933,0.03827837,-0.0009968892,-0.030484192,0.053869937,-0.014034463,0.044013634,-0.03565358,-0.15512261,-0.036171615,0.039992355,0.006248442,-0.034946535,-0.030041646,0.016315801,-0.07679281,0.07027594,-0.117850706,0.06355506,-0.013349095,0.01644268,0.021648154,0.067527875,-0.028188713,-0.009534069,0.0015622266,0.013777955,0.08187933,-0.028902445,0.032834657,0.018359305,-0.030090488,-0.048563015,0.07024135,0.113386236,0.0111841215,0.07163944,-0.044170305,0.029771125,0.011742641,-0.028883522,-0.042642243,0.008423384,-0.016220357,0.028580364,0.06544675,0.03923023,0.008409419,0.0027441895,-0.009122504,0.038575944,-0.032098044,-0.018474553,0.07620159,0.061499476,-0.04066564,-0.13471392,-0.014903035,-0.038928743,-0.09796204,0.0351211,0.02155578,-0.017204424,-0.039396506,-0.042646207,1.4345951e-33,0.052391976,0.04949114,-0.040003683,-0.029284667,0.057307802,-0.0066635446,-0.037525658,0.065110475,0.053912874,-0.051858325,0.0045452323,-0.062328026,0.0040835147,-0.03419971,-0.034503806,-0.02473919,-0.06879844,-0.034796864,0.033128098,0.016744232,-0.040225692,0.020699747,-0.10290428,0.018987335,0.061340302,0.04127696,0.01777523,-0.053315345,-0.034053504,-0.003730517,0.01738867,-0.07944317,-0.14357741,-0.0018917847,0.014275534,0.017069438,-0.03478747,-0.00040250795,-0.013781838,0.054690458,0.009705123,0.043145306,0.036103766,-0.06662624,-0.00067048013,-0.015082717,-0.030181902,0.122544006,0.022047047,0.07420619,0.02961675,-0.04750735,0.08544455,-0.076825544,-0.066850506,0.020542134,-0.013963603,-0.012289736,0.018062891,0.050703228,0.04862709,0.047494713,-0.08364077,0.059881344,-0.020681111,-0.06039041,-0.04111585,-0.03338267,0.043571927,0.013955755,-0.0678266,0.007186653,0.047236532,-0.0005056432,-0.00092545076,-0.0029070743,-0.066005096,0.018549036,0.0012437876,-0.013341462,0.032688525,-0.012373557,0.0637443,-0.04603459,-0.0920534,0.063764326,0.050499342,-0.021269448,0.012714453,0.02601579,0.038844958,-0.1266822,-0.009342419,0.007837293,0.03870156,-2.266497e-33,0.090787955,-0.007334783,0.021583255,-0.04142021,-0.026856055,0.09091374,0.0010569309,0.02688905,-0.04651161,-0.022014799,0.123216674,0.024482427,0.03440833,0.005584403,0.07668851,0.043669645,0.0104353335,-0.00052917795,-0.077025935,-0.054391894,0.011352913,0.041175846,-0.003755462,0.008500189,0.020533338,0.024826141,-0.015577798,0.033133134,0.09441979,0.06801279,-0.0024598716,0.017636407,-0.018184735,0.03088698,0.09153074,-0.011350556,-0.07767591,0.055786736,-0.00408227,0.048316203,0.051341977,0.018981824,-0.02507933,0.04816111,-0.0075459746,0.052501258,-0.10704676,-0.0390451,0.06920641,-0.09277578,0.046896286,0.013407318,-0.08253311,0.040516682,0.034589533,0.031780392,0.0063796034,-0.012976812,-0.06722691,-0.042156078,-0.11176703,-0.036165766,0.04545354,0.012074029,-0.016773252,0.014248383,-0.06602016,0.080609724,-0.03502538,-0.017382082,0.055005275,0.033936765,-0.0009308091,0.06686804,-0.13902941,-0.03657389,-0.02556374,-0.048257403,-0.023721408,0.02814788,0.06049115,0.024806513,-0.0043276846,-0.09416291,-0.020544436,-0.06829025,0.029999014,0.11839855,-0.057235926,-0.01809537,0.078831404,0.018817715,-0.06801314,0.0025836253,0.033626363,-3.826138e-08,-0.022692664,-0.031704992,0.11114769,-0.002678052,-0.0049006967,0.03695455,0.09898931,0.061370496,0.088068105,-0.046594605,-0.016280407,0.031786773,0.028259203,0.04101804,0.036507934,-0.015444048,-0.12701517,-0.0049092127,-0.017469844,-0.034621157,-0.111534074,-0.07605613,-0.121354684,0.016248152,-0.009596953,-0.019104054,0.03665342,-0.01708447,0.09958555,-0.07569728,-0.045563508,0.06040342,-0.009146292,0.01023779,-0.1028124,0.025349947,-0.024398124,-0.04842104,-0.06660923,0.05867981,-0.01656299,-0.07054745,-0.08277761,0.045447607,0.11272054,-0.0059448755,0.001735764,-0.004921669,0.008070527,-0.039785653,0.05877374,0.008976738,0.048841376,0.006479173,-0.060458757,0.03363972,-0.033780843,0.008153497,-0.044245884,-0.0416433,0.02619549,-0.0055372394,0.11344755,-0.017838689 +1.2.1.97,"The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway. Also acts on succinate semialdehyde.",384,1.0,-0.04968618,-0.061439037,-0.109732315,0.017187055,0.04371968,0.089119606,-0.08557062,0.027108077,0.01488132,-0.050621007,0.034618407,0.023286147,-0.025739942,0.081492364,-0.06996976,0.09280264,-0.061942454,0.015286498,-0.017200487,-0.003961244,0.07037011,0.05458592,-0.08671663,0.047393844,0.08537111,0.03182577,0.02137426,-9.4509254e-05,-0.08267657,0.029244328,0.0063311504,-0.055595893,0.028498502,-0.0402837,0.04716855,0.09044975,-0.024201928,-0.014681099,0.08415764,-0.0620873,-0.0055305413,-0.038888786,-0.062468868,-0.03882953,-0.006357996,0.015523094,0.028009731,0.051744405,0.052898936,-0.07778992,-0.09814292,-0.03722631,0.0015760084,0.03226373,0.028687408,0.07011884,0.022820033,0.013933704,-0.020084584,0.0049610767,-0.01294441,-0.026783794,-0.012265249,0.015097387,-0.01748081,-0.019933453,0.048734985,-0.042457964,0.0016796789,0.010173813,-0.08089193,-0.049541682,0.011977031,0.035743363,0.0074434765,0.0044164695,-0.036574803,-0.025480445,0.048034653,-0.07076069,0.03800346,-0.017449526,0.026822744,0.073053434,-0.007588109,-0.038909353,0.12449592,-0.03395365,0.076481745,0.0067702853,0.0001934564,-0.027895024,-0.027714932,-0.05479894,-0.05834768,0.043390416,-0.0020908874,0.046358436,0.044500597,-0.024958897,-0.0015278574,0.011195642,-0.03226317,-0.12982605,-0.048849184,0.026852282,0.024859501,0.07275564,0.023595857,0.039319057,-0.006239454,-0.023002725,0.0057127364,-0.019749446,-0.0032526513,0.07967887,0.09661925,-0.009272073,-0.1243098,-0.010362606,-0.021853345,-0.017263707,0.045365084,0.0563973,-0.031206973,0.06884907,-0.1243315,8.448349e-34,0.09440465,-0.007028353,0.009753466,-0.06995897,0.01811138,-0.0346865,-0.10689143,0.06407784,0.019026786,-0.007196886,0.018553393,-0.10155228,-0.013790684,-0.026861288,0.001701566,0.016772358,-0.020482538,-0.0071286615,0.04090938,-0.00016908789,-0.011173132,0.034735072,-0.05588187,-0.024414983,0.040134497,0.041407432,0.053853206,-0.0041637626,-0.04209505,-0.0012381935,0.085305914,-0.07469872,-0.17344703,-0.06829525,0.07215533,-0.045363996,-0.02680766,-0.013419125,-0.009074341,0.058145788,0.016078072,0.057351835,0.010081706,-0.04602643,0.062393248,-0.074679926,-0.01094722,0.17376937,0.05254727,0.09598057,-0.029607678,-0.08764678,0.08124676,0.05498832,-0.012013793,-0.013542064,0.01701449,0.01237701,0.036585134,-0.027850728,0.010454644,-0.007912782,-0.057719108,-0.048541635,0.019382989,-0.018130291,-0.07591984,0.030371565,0.017482098,-0.009422628,-0.083560474,0.0042362865,-0.046830118,0.029530242,-0.0348546,-0.07688778,-0.040656384,0.038804647,0.040811487,0.026747333,-0.08054736,-0.07448629,-0.0041707014,-0.064076014,-0.08305229,0.02205309,-0.0064277444,-0.04913054,-0.09511296,-0.031489484,0.05240389,-0.08806573,-0.026020255,0.06530282,0.019010065,-2.1500256e-33,0.04275844,-0.056295536,0.054861803,-0.035181165,-0.01754388,0.017536344,-0.062184423,0.057946697,-0.024811283,-0.008520842,-0.014526095,0.0051191114,0.074624,-0.037978843,0.02488618,0.0032211032,0.036601923,-0.017038092,-0.03839142,-0.007982615,-0.005897517,0.13209994,-0.023307132,0.040359102,0.06048981,0.0411205,0.007911754,0.108680196,0.04151908,0.116855346,0.033488803,0.022261394,-0.052871842,-0.014196183,0.0053651617,0.0054359497,-0.027766192,-0.0129032945,0.049720917,0.03723396,0.061614968,0.02124932,-0.0123703275,0.10588864,-0.0043552346,0.051653847,-0.09815877,0.054303657,0.033721145,-0.10045611,0.037760135,-0.005747103,0.0028548602,0.033066817,0.02358965,-0.010575604,-0.021678062,-0.010434001,-0.09667314,-0.059188064,-0.018522644,-0.050133247,0.013300957,0.00879556,0.005496643,0.03343817,-0.04592639,0.040561717,0.0047818916,-0.04884761,0.026173057,-0.035377905,-0.029306266,0.016780656,-0.08649975,-0.033270888,-0.07536532,0.01906862,0.022626624,0.068895206,0.047242317,-0.009769226,-0.045479372,-0.10285498,0.043734793,-0.057567965,-0.011331822,0.083203115,-0.06103638,0.015199208,-0.04720481,0.039701253,-0.032743003,0.063703306,0.0090654,-2.6361093e-08,0.03978904,-0.031927016,0.10712691,0.019797808,-0.010620722,-0.024314554,0.01189939,0.054542307,0.022444718,0.011880023,-0.06080143,0.06112902,-0.00801872,0.016323367,0.054398023,-0.01403689,-0.05395738,0.019415244,-0.0511835,-0.008550008,-0.05877544,-0.10941318,-0.10431894,0.057527844,0.024154618,-0.06501346,0.10258101,0.00952942,0.012735512,-0.038902506,-0.009257064,0.024952501,0.026309008,0.0058504264,-0.06078684,0.078525074,-0.018541975,-0.02967056,-0.005790777,0.06623565,0.021722583,-0.013719074,-0.09670802,-0.00015510448,0.01767585,0.019971332,0.06321477,0.028236037,-0.06419925,-0.040709198,0.0630096,-0.021833451,0.010724576,0.019572364,-0.086806834,0.043435078,0.029922402,0.014716751,0.027358474,0.06763246,-0.013490947,0.01860745,0.1503696,-0.004159374 +1.3.1.108,"The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA.",384,1.0,-0.04139878,0.021566503,-0.09780516,0.06918661,0.071476266,0.036745578,-0.09668865,0.024691347,0.0320248,-0.057687078,-0.03134681,-0.07294662,-0.034559466,-0.010329585,-0.06158586,-0.03435672,-0.057949204,0.037842777,0.007573908,-0.03597594,-0.008869419,-0.012736956,-0.0032967958,-0.02886501,0.02570508,0.036860913,0.011877488,-0.058550008,-0.038837522,-0.11278742,0.06281988,0.01271087,0.038935263,-0.022628382,-0.012777557,0.10621441,0.023505243,-0.002908383,0.079831265,0.020087965,-0.030017411,0.04712066,0.046540696,-0.039193153,-0.05405032,-0.02956037,-0.0031487558,-0.011968779,0.057615694,-0.054457583,-0.024940925,-0.030454522,-0.08119909,0.049850214,0.0612026,-0.015169883,0.04397826,-0.08399625,0.028083008,0.032047402,0.10299906,-0.020925228,-0.022704192,0.047328547,-0.02909087,-0.020274032,0.057900257,-0.0779361,-0.013390115,-0.036005303,-0.023487847,0.01323898,-0.0047482266,-0.047520738,0.011217053,0.04039279,-0.024326181,-0.015318576,0.10577771,0.014669236,-0.027769692,0.0017118587,-0.004147941,0.056997236,0.01787446,0.0014565977,0.011447007,-0.09436768,-0.009920729,0.021697229,0.0359522,0.05384397,-0.019579716,-0.027247194,-0.09403805,0.014357244,0.06098917,-0.03122442,0.017041087,-0.014225224,-0.017162582,0.06284569,0.01901783,-0.121294536,-0.054512423,-0.055338234,-0.013964142,0.15801705,0.07376105,0.0143022835,-0.0037122318,-0.0060847807,0.008111347,0.017543923,-0.040492352,0.096727155,0.047908418,-0.07245472,-0.031146571,0.03500735,0.049286958,0.014020063,0.059009694,0.01462903,0.050013673,-0.030181548,-0.09925362,4.0538e-33,0.10047062,0.0064231986,-0.006109885,-0.044334754,0.08552716,-0.033616625,-0.12634704,0.011301647,0.0053311666,0.009932639,-0.070699826,-0.043899514,0.083409674,-0.056062978,0.006023912,-0.07027541,-0.06833576,-0.067297034,0.025337962,-0.015951296,0.07340262,0.058049545,-0.012879404,0.09368353,0.0033362356,0.07290296,-0.03528834,0.05596553,0.026116155,0.01819014,0.025928892,-0.028015655,-0.1450356,-0.0041628634,0.040918425,0.0036117793,-0.014584384,-0.02042362,-0.03694113,0.055651363,0.0012652065,0.04505995,-0.046037603,-0.06455562,0.13325395,-0.13127485,-0.040425368,0.10652435,0.035659187,0.11330844,0.034687035,-0.040806644,0.13166587,0.047580782,-0.047683876,0.040198598,-0.009964148,0.027999835,0.03561337,0.028122459,0.0682597,0.018511292,-0.0011136014,0.014810451,-0.005287671,0.04173183,0.04300494,-0.01915669,-0.025160525,0.030640721,-0.020368306,0.019337766,0.07911597,0.02354955,0.03648931,-0.04156117,-0.07110855,-0.021834897,0.060482357,-0.057993278,-0.0071768155,0.011174202,-0.0055538476,-0.06281129,-0.0042225625,-0.038331967,-0.017357863,-0.012543455,-0.007933389,-0.000607153,0.04772975,-0.033040214,-0.014160763,0.0008773577,-0.009129194,-4.008058e-33,0.08873597,-0.09238569,0.055705,-0.064704984,-0.06368362,0.070619784,0.0689961,-0.00027605976,-0.015648898,-0.00625834,0.1261496,0.01601201,0.03582223,-0.0032903077,0.038060732,0.020722061,-0.0024054744,-0.009275457,0.0186253,0.0226994,0.00018831083,0.0037732604,0.0018388062,-0.044312008,0.10558909,-0.008078014,-0.058799688,-0.02718592,0.06389493,0.040214196,0.010389451,-0.040960453,-0.050122168,-0.03187503,-0.07629454,0.042214014,-0.07646082,0.038374852,0.021837248,0.00072199036,0.0045972406,-0.005451005,-0.023860427,0.101081625,0.090227,0.005513471,-0.117851876,-0.0052923122,0.0011597063,-9.2606046e-05,0.00067296566,-0.017772622,-0.03944881,-0.031226728,-0.025144935,0.033195425,0.057780463,0.038706176,-0.04232125,-0.004368647,-0.06064897,-0.074674875,0.07108017,0.04257102,0.09363033,0.035465468,-0.031492133,0.097473875,0.037103266,-0.022249475,0.05197951,0.022773564,0.06507804,0.08067581,0.039247934,0.012705003,0.02383833,-0.045792185,-0.056007966,0.0031515816,-0.021414822,0.0488211,-0.03831838,-0.08158558,-0.09931438,-0.1046702,0.0032296597,0.059443574,0.0032532103,0.018992823,-0.047105126,0.012833707,0.06020877,0.018132841,0.056609813,-3.6251315e-08,-0.035899356,-0.028744021,0.032261766,-0.035135005,0.05197752,0.02712065,-0.016121112,-0.025067281,0.012277709,-0.09208844,0.010534927,0.13517031,-0.01271006,0.031580407,0.020131055,-0.0041298494,-0.041706596,-0.019144353,-0.004414167,-0.021020707,-0.09394269,-0.05471457,-0.109671354,0.037216455,0.029267136,-0.086975746,0.016671361,-0.010370262,-0.05531813,-0.061296,-0.06062009,0.07204893,-0.0022822053,-0.014678075,-0.102038875,0.029981298,-0.06736271,0.032272704,-0.049237065,0.08453094,0.02844467,-0.03551614,-0.09254245,-0.02348425,-0.004244909,0.031069985,-0.014781655,0.02094322,-0.02080135,0.024234472,0.016363587,-0.0126692625,0.008110399,-0.027787225,-0.11371054,0.06755626,-0.021547263,-0.020790478,0.026559887,-0.048764087,-0.022152726,-0.028321587,0.08169159,0.009047353 +1.3.1.109,"The enzyme is a complex of a flavin-containing dehydrogenase component (Bcd) and an electron-transfer flavoprotein dimer (EtfAB). The enzyme complex, isolated from the bacteria Acidaminococcus fermentans and butanoate-producing Clostridia species, couples the exergonic reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA by NADH to the endergonic reduction of ferredoxin by NADH, using electron bifurcation to overcome the steep energy barrier in ferredoxin reduction.",384,1.0,-0.09728953,0.03007797,-0.11083525,0.0077506523,0.10343905,-0.008415331,-0.11517866,-0.00027970524,0.013353957,-0.042019416,-0.015028814,-0.070021644,-0.04671182,0.026240291,-0.069607936,-0.002404829,-0.06338967,0.020475805,0.01141164,0.0521193,0.012618529,0.066470824,0.004265867,0.0050387615,0.0040117376,0.06378321,0.044101592,0.018942455,-0.02137786,-0.08679813,0.06747315,-0.016354373,0.0700645,-0.035948783,-0.00028613373,0.077257946,0.010054072,0.0022891404,0.081913665,-0.014591109,-0.005465113,0.04798185,0.028640822,-0.092392385,-0.035980854,-0.019248763,0.0062387553,0.02940499,0.043986548,0.0010391381,0.005050366,-0.008307258,-0.08721571,0.061428905,0.065784425,-0.028261546,-0.0077364,-0.034413178,-0.062424283,-0.0075344634,0.08560172,-0.022466764,0.012771006,0.06476058,0.0035016409,-0.05267917,0.045960553,-0.042069003,-0.021737147,-0.10835204,-0.041676767,-0.022279244,-0.013191298,0.012890416,0.020356294,0.071053624,-0.00677777,-0.029575193,0.036421675,0.017811945,0.053409405,0.0016480685,-0.0251975,0.091816954,0.032021873,-0.032085367,0.0072067566,-0.015073508,0.025706377,0.035102032,0.03507123,0.03671978,0.0042480445,-0.040837497,-0.055222217,0.057084613,0.027704068,0.053656287,-0.03368417,-0.019918678,-0.07074134,0.05132559,0.0289117,-0.11463423,-0.06263322,-0.05947501,0.04354179,0.13210386,0.022129085,-0.05698808,0.013051738,-0.009975966,0.0707217,0.019447668,0.017121576,0.0850461,0.029576069,-0.057867743,-0.030337736,0.026014108,0.054784127,0.01125575,0.059563957,0.05446157,0.008829294,0.032078244,-0.09656529,4.4375055e-33,0.06823055,-0.0017994166,-0.027525706,-0.030686,0.06598134,0.008555094,-0.07859038,0.028163414,-0.017466094,0.0060094516,-0.068121344,-0.062275458,0.10788839,-0.063467816,-0.01598239,-0.041978642,-0.05855831,-0.035940878,0.040712483,-0.016875213,0.115149625,0.06350239,0.009685872,0.02697518,0.02232955,0.09677626,-0.047734767,0.05644343,0.019423928,-0.0066186585,0.07754219,-0.101689845,-0.12882322,-0.0143689215,0.08561362,0.019956036,-0.039941315,-0.052692194,-0.03066541,0.035049886,-0.07002338,0.030382983,-0.08093915,-0.019025657,0.043296494,-0.077529766,0.00035303924,0.09801345,0.04460437,0.08946987,0.07753581,-0.073300794,0.10252584,-0.08751212,-0.0589006,0.07361113,-0.004864652,0.019000757,0.015489007,0.06551459,0.017691134,0.06491972,-0.020121355,0.024949906,0.027598266,-0.034837466,-0.011615636,-0.04176998,0.02526958,0.013368319,-0.008968038,0.005099184,0.090205744,0.0057221027,0.083935976,-0.02168332,-0.07285072,-0.053127076,0.06370119,0.00329569,-0.01807493,-0.028227031,-0.010686241,-0.06934751,-0.009400703,0.025660003,-0.07586965,-0.0037986897,-0.01565416,0.009636781,0.022540895,-0.07656834,-0.030202439,-0.06626112,0.03489148,-4.720038e-33,0.071872436,-0.117139965,0.025564808,-0.070171066,-0.049924906,0.10856013,0.06033029,-0.009066587,0.009153562,6.788147e-05,0.074558176,-0.005071343,0.036966957,-0.018881194,0.08096905,0.07912558,-0.030618645,-0.0029974477,0.019460445,-0.030079382,0.021288792,0.031002676,0.015156722,-0.015133672,0.056832254,0.013026368,-0.024162818,0.0017813613,0.0836788,0.030749207,-0.06981439,-0.03138724,-0.089479014,-0.03889795,-0.05373655,0.10015323,-0.09509117,-0.022997668,0.022874828,-0.009173105,-0.028530775,0.013546835,-0.06844089,0.030694762,0.07638553,0.028966393,-0.12719327,0.0053432696,0.040264424,0.017845364,-0.011796767,0.018464813,-0.02411067,-0.0111303525,0.024195492,-0.00047308952,0.076855935,0.012038035,-0.05068945,-0.04627756,-0.031390138,-0.12956208,0.0061911447,0.042132773,0.038990103,0.058166124,0.010688693,0.034139317,0.04195535,-0.08387966,0.060877018,-0.059856243,0.049049336,0.03348597,-0.019670008,-0.023000676,0.015573551,0.0075524766,-0.019572055,-0.001649622,0.021621,-0.0054543475,-0.0065137977,-0.062704705,-0.014754093,-0.071845,-0.036106363,0.02238668,0.019684006,0.02667153,-0.055110916,0.049479503,0.03155806,0.009423284,0.034106344,-4.366817e-08,-0.0030464106,-0.07787807,0.058104955,-0.030093407,0.06847975,0.016633006,-0.03407923,-0.06044548,-0.0010595447,-0.04187986,0.07271825,0.12280463,0.023805207,0.032515932,0.052229933,-0.017742634,0.0031177278,-0.01540756,-0.028555932,-0.03188821,-0.0872476,-0.042051837,-0.1568846,0.039191198,0.016837236,-0.05142518,-0.004215133,-0.048447985,0.035123758,-0.050121907,-0.015136765,0.031249432,0.026581308,-0.016096944,-0.1110014,-0.007911786,-0.042445835,-0.0014623097,-0.06405758,0.08185344,-0.000693689,-0.009276289,-0.04818718,-0.01302721,0.028991925,0.058778584,0.006806409,0.03525703,-0.063543364,0.019850198,0.045491766,-0.03684665,-0.010125063,-0.015533435,-0.10152909,0.043284595,0.0011742725,-0.056140944,0.008665439,-0.042966664,-0.02600321,0.03705428,0.14144118,-0.021536324 +1.3.1.110,"The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+. 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In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this 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+1.6.5.12,"The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.",384,1.0,-0.10906982,0.038212657,-0.09909185,0.006821943,0.027311467,0.0225394,-0.04330418,0.021634854,0.0034698527,0.034917705,0.071404755,-0.04243718,-0.06032491,0.030123796,-0.03620781,0.09448689,-0.11555141,0.023564117,0.0028064735,0.0034148744,-0.0007749705,0.006012678,-0.00014576013,0.020369979,0.061928667,0.004425991,-0.023129309,0.015286076,-0.04681894,0.003407678,-0.024667878,-0.046911214,0.040173665,-0.011289124,0.05553007,0.11384197,-0.044918083,-0.120804936,-0.005194002,0.0624102,0.012783319,-0.03329795,-0.055202,0.013595672,-0.019767947,0.0050851377,0.020675417,0.09287875,0.0044884593,-0.021583134,-0.0731636,-0.019397765,-0.05009277,0.034225184,0.014051968,0.02650796,-0.04638021,0.043443717,-0.007431537,0.022797797,0.055663776,-0.043930482,-0.038658418,0.014030517,0.04514805,-0.059508245,-0.007410349,-0.037937187,0.06986566,-0.1305256,-0.037532963,-0.09255881,-0.019717459,0.024595626,-0.058560822,0.051109076,-0.019586414,-0.0066774176,0.017648881,-0.035086304,0.06740052,-0.011121173,-0.029667266,0.060877,0.07117592,-0.029240688,0.014702012,0.02692674,0.008631712,0.0029816453,0.011503371,-0.046897326,-0.04032909,-0.051498152,-0.09447844,0.07823318,0.055482514,-0.014824332,0.004787067,-0.015256519,0.002860463,0.052261204,-0.0025605487,-0.043888245,-0.05228913,-0.00734899,-0.061173264,0.039868545,-0.052726123,-0.02200711,-0.03333294,0.018551715,-0.045576863,-0.00044365684,0.03181899,0.055405196,0.045066006,-0.075371906,-0.07899749,0.024373243,-0.033250205,-0.031896982,0.0111849895,0.041494537,-0.026780859,0.0032838946,-0.097446226,2.465364e-33,0.085910775,0.050665375,0.04662534,-0.036962252,0.031284064,-0.024666237,-0.055716705,0.059574064,-0.09310217,-0.12700802,-0.08256129,-0.080995634,0.069362156,-0.016076352,-0.010731092,0.043792415,-0.05601824,-0.068258025,0.054810088,0.08405038,0.019339046,0.007390949,-0.03824114,0.07338638,-0.03469072,0.07978101,-0.02477598,-0.0014494709,0.013850361,0.0024827563,0.049610544,-0.095945545,-0.03831218,-0.008137106,0.075952195,-0.04678797,-0.08157942,-0.07455113,-0.02968561,0.05781657,-0.090552494,0.026227687,0.024907866,0.038150433,0.012121442,0.016723739,-0.05017539,0.05120218,0.048027866,0.03625014,0.030924007,0.020871997,0.088363364,-0.015144144,-0.03861231,0.060380872,0.014213841,-0.05546994,-0.007841507,-0.00937951,-0.012937449,0.03406326,0.0015306519,0.079007074,-0.026121963,0.006489198,-0.08315289,0.013823961,-0.019678708,0.07042173,-0.037218343,-0.016382582,0.027827688,-0.03239409,0.067486316,0.029067807,-0.018286152,-0.037764315,-0.09028374,0.017035646,0.002020523,-0.0695342,0.0030297076,-0.03958292,-0.09508175,-0.035816677,-0.012471958,-0.04349978,0.006616485,0.020420149,0.034603097,-0.011935538,-0.0096281,-0.055107206,0.044301238,-4.407565e-33,0.11345874,-0.07013985,0.054692585,-0.082654,-0.01624262,0.11921679,-0.03980713,-0.07009036,0.04061262,0.05964986,0.045160435,0.030325172,0.02518482,-0.009407981,0.039300513,0.041323982,-0.039193835,0.10722104,0.0010171582,-0.0028450536,-0.017618913,0.062814705,0.04074945,-0.01545097,0.03893662,0.0061167483,-0.0616927,0.04432868,0.054720882,0.030279573,-0.07347284,-0.017076045,-0.008984027,-0.043103263,0.036817316,0.06946851,-0.06186902,-0.046567068,0.040992778,0.102188185,0.04078387,-0.018967714,-0.004007399,0.02916174,0.012543454,0.02080097,-0.057829525,0.06746812,-0.014680394,-0.056113277,0.057185255,0.08798394,-0.025644895,0.03813227,0.05694333,0.07808904,-0.010252605,0.069141485,0.009871784,-0.018552026,0.005011428,-0.16850989,0.012369668,0.01779808,0.00871052,0.010912648,0.013294819,0.07513052,-0.016712144,0.032971468,0.07709655,0.041143067,0.07172558,0.05940517,-0.06274714,-0.01512009,-0.076070756,-0.012001007,-0.038377818,-0.012529658,0.043373927,-0.032788374,0.045225315,-0.04366602,-0.0050315615,-0.059250843,0.015278145,0.048872642,-0.042844847,-0.02086657,-0.029589612,0.024727363,-0.0567439,0.069484204,0.04949003,-3.69259e-08,0.023249995,-0.06471304,0.035015088,-0.05943695,0.08644875,0.00073339394,0.0050219735,0.04622783,0.05531653,0.013974322,0.04803965,0.08674377,0.063950166,-0.0026732087,0.058114544,0.01473531,0.016521523,-0.02554237,-0.025459297,0.065176174,-0.07828279,-0.04534332,-0.12719536,0.014737194,-0.043647937,-0.03585047,0.013962972,0.03264228,0.0018923327,-0.041488886,0.07532901,0.00493791,0.05220593,-0.045433152,-0.1433958,0.03933769,-0.060886372,-0.0641268,-0.043767974,-0.015177195,-0.037811443,-0.030056162,-0.03305572,0.07373572,-0.012625013,0.04601153,0.08822276,-0.0093882615,-0.04084561,0.047129475,-0.052065972,0.020868411,-0.005591193,-0.07869557,-0.1046735,0.01974741,0.035113625,-0.078759976,-0.03352322,-0.07185768,-0.013092374,0.018947417,0.18454692,0.005424135 +1.13.11.81,"The enzyme from the bacterium Mycobacterium tuberculosis is multifunctional and also catalyses the epimerisation of the 2'-hydroxy group of 7,8-dihydroneopterin (EC 5.1.99.8, 7,8-dihydroneopterin epimerase) and the reaction of EC 4.1.2.25 (dihydroneopterin aldolase).",384,0.99999994,-0.040214892,-0.02773997,-0.02418339,-0.03424667,0.07756074,0.04494419,0.0039207214,0.066969216,-0.030074738,0.04537097,-0.023956308,-0.07125646,0.036206797,0.038110442,-0.033172466,0.08398082,-0.06773978,-0.022814693,-0.015171163,-0.026579758,0.027921746,0.04768614,0.047673084,-0.01953129,0.083185345,0.03302903,0.06993069,-0.01568138,-0.01979258,-0.082450844,0.03371943,-0.1125392,0.041143984,-0.05158401,0.040657848,0.13972259,-0.03363899,-0.09599569,0.06927183,0.057377003,0.037110876,0.0154046435,-0.03527809,0.009727029,0.043845076,0.0148617625,-0.0017251825,0.12676942,0.04694827,0.028152097,-0.019588435,-0.060998242,-0.05844755,0.016241072,0.047160886,0.0046345186,-0.0470781,0.038194492,0.04536512,0.020631239,0.08533044,-0.008809338,0.0124191055,0.025731295,0.035526946,-0.012285422,-0.0121113,-0.0731725,0.003028786,-0.05866739,-0.0421115,-0.025333513,-0.05893073,0.06782509,0.024624592,-0.038437296,-0.06590029,-0.031980377,-0.02614738,0.059115548,-0.01781053,-0.012673281,0.016674228,0.007630453,0.07786508,-0.04057582,0.07518212,0.019450523,0.05039176,0.01966075,0.054858793,-0.057028618,-0.0075192205,0.010816017,-0.043618243,0.023254683,0.040476236,0.0130447345,0.03748002,-0.006479522,-0.018895676,0.007846194,-0.066708565,-0.08141007,-0.057172727,0.008015155,-0.033660688,0.08602959,0.015591758,0.0060058585,-0.021889567,-0.015874563,0.033507325,0.026119523,-0.013661277,0.06967149,0.035139512,-0.056213934,-0.029274978,0.016880631,0.024661504,-0.048352756,0.09928874,0.07776511,-0.11452363,0.036759425,-0.057485748,2.7949118e-33,0.015017145,-0.05359391,0.004030969,-0.041118737,0.056572728,0.049597714,-0.08250776,0.031961672,-0.050493658,-0.11451957,-0.07671107,-0.066536784,0.074538484,0.05302711,-0.06293276,0.0056855036,-0.010777214,0.040582724,0.12082684,0.045514453,0.019711774,0.040143955,-0.036322318,0.055544727,-0.003150071,0.04629369,0.023169303,0.061288796,0.09203584,-0.022096852,-0.021915859,-0.075619325,-0.09870465,-0.043155324,-0.028619602,-0.016182123,-0.031137038,-0.028198378,0.058203593,0.050870262,-0.006917448,0.012171395,0.030511074,-0.08385103,0.08139115,-0.022726929,-0.003119058,0.023344845,-0.020428801,-0.022784166,0.028130682,-0.0042786184,0.07415692,-0.025344392,-0.018732157,-0.004184416,-0.016396374,0.06573067,0.08213641,0.02362264,0.054404736,0.082469225,0.0092765475,0.04014135,-0.07393322,-0.021028616,-0.030107561,0.023319745,0.03452022,0.055302434,-0.033669602,-0.027342448,0.04819364,-0.045954745,0.04150083,-0.052769314,-0.11690468,-0.052866705,-0.0038040865,0.013371138,-0.014332876,0.022272084,0.007337133,0.009688855,-0.012126524,-0.036550708,-0.09117042,-0.084784724,-0.0048695775,0.014804948,-0.018766528,-0.029943125,-0.09231396,0.043801818,0.015618699,-2.7855954e-33,0.15111205,-0.13619192,0.1122983,-0.04865726,0.004056169,-0.0050612865,0.018996505,-0.030589087,0.049326345,0.029341735,0.07447253,-0.05468378,-0.007881773,-0.03964119,-0.010704166,0.047627557,0.008562354,0.104861505,-0.028845845,-0.018387608,0.008350633,0.010239938,0.018636726,-0.0371809,0.014314553,0.012975871,-0.005787546,0.013507267,0.11384026,0.07485436,-0.07918654,-0.0023352923,-0.04080234,-0.014420019,-0.1043909,0.052609004,-0.0621994,-0.05285314,0.042691436,-0.022440739,0.067469664,0.06557773,0.0042821565,-0.007282878,0.035087623,0.030673023,-0.037818193,0.019583,-0.0067172106,-0.031832807,0.008479077,-0.000695806,-0.010286163,-0.012902742,-0.0034936618,0.0065526655,0.053379502,0.0040159463,0.020105382,-0.04629753,-0.038322542,-0.044160012,0.047810562,-0.0076307417,0.048763223,0.07223004,-0.07267788,0.08384497,0.051899355,-0.01734068,0.06701046,-0.10023995,-0.026341328,0.058443937,0.05435496,0.008865184,-0.055220306,-0.015238899,0.032951362,-0.022382746,-0.021568136,-0.004312843,-0.020345418,-0.056953035,-0.04052208,-0.048377093,0.028193593,0.09794802,-0.06696086,0.10728032,0.017285282,-0.019564772,-0.031382143,0.066463135,0.106393024,-4.0481886e-08,0.0024018553,-0.05755968,0.11242299,-0.038616307,0.015718704,-0.022319645,0.033215366,0.050747216,0.060514007,-0.0934004,0.057538953,-0.017182617,0.022484364,-0.0043108054,0.06696333,0.007993558,-0.013744615,-0.04597333,-0.03012861,-0.026486862,-0.023865731,-0.031622365,0.00018876408,0.021064214,-0.050146967,-0.065202706,-0.016087124,0.078372106,-0.05616802,-0.003035673,-0.076021224,0.002529518,-0.047978275,-0.10068931,-0.071886,0.017219802,-0.027630303,-0.04564577,-0.029040016,-0.025815964,-0.003902069,-0.093292706,-0.048371505,0.0025894197,0.032815807,0.0005837096,-0.0026138322,0.02895036,0.002010191,-0.011746389,0.08307089,-0.05457747,0.0125888735,-0.053232066,-0.08222985,0.077123135,-0.051987834,-0.0653933,-0.0315072,-0.0745054,0.033681765,0.004622497,0.18382065,-0.07000641 +1.13.11.82,Isolated from the bacterium Novosphingobium aromaticivorans. It is less active with 4'-apo-beta-carotenal and gamma-carotene.,384,1.0,-0.06543016,-0.03012402,-0.13219506,0.008447953,-0.057262965,0.074901484,-0.0021897077,0.05820044,0.0520784,-0.049162097,0.053543076,-0.08407527,-0.02468623,0.027969616,-0.0124829635,0.049369507,0.064139396,-0.057160057,0.08158898,0.043793347,2.0706464e-05,0.008845666,-0.008286087,-0.027348826,0.036529135,0.03406484,0.08105,-0.03463416,0.0059368825,-0.067411564,0.04308126,-0.06058041,0.025766056,-0.05556091,0.14837444,0.049160913,-0.047268435,-0.021039208,0.11528141,0.058779247,0.035887968,-0.0058331583,0.037267182,-0.020493552,-0.0077233077,0.04102967,-0.055833362,0.065675974,0.050262235,-0.14661464,-0.03334712,-0.05229597,-0.08013673,0.06948252,0.022691311,-0.00960513,0.010232405,-0.0066261576,-0.040578377,0.011989016,0.07422668,-0.0015949372,0.09765131,-0.0016109727,-0.07112498,-0.0031118072,-0.019622596,-0.06007111,0.04350969,-0.07196967,-0.06336414,-0.028262075,0.053813536,0.014561349,-0.05343222,0.0046577607,0.008611366,0.011335628,0.03070042,-0.09096176,0.066556685,-0.009922763,-0.036137912,0.039342634,-0.018163573,-0.015812477,0.013934154,0.041348003,0.029321957,0.054143485,-0.015566112,-0.014036362,0.024430487,-0.05966542,-0.102679566,-0.018523257,0.06294593,-0.053659152,0.044869006,-0.006674046,-0.0037851036,0.040149756,-0.006631843,-0.07671787,-0.12605794,0.027768578,0.014066132,0.05093394,0.09403915,0.03303156,-0.02211419,0.08982212,0.014336894,-0.090329595,-0.043283712,-0.0376343,0.040427525,-0.047508415,-0.061617322,0.056353305,-0.031165468,-0.026425377,0.075853504,0.00315119,-0.0064004892,0.04617041,-0.070015214,4.2647752e-34,0.08610077,0.04171702,0.037167095,-0.0035920737,0.008812481,0.0074059097,-0.059529245,-0.108371966,-0.028164292,-0.04919283,-0.11026955,-0.10358451,0.017416466,0.045039654,0.0024859903,0.04012068,-0.042759612,0.052916817,0.033013117,-0.035465408,0.006150801,0.04630239,-0.020364199,-0.0059967632,0.035633713,0.009374884,-0.046151277,-0.03226809,-0.010130724,0.0072811022,0.027670646,-0.018345132,-0.16288193,0.008571173,0.08761548,-0.05970961,-0.079635665,-0.076165244,-0.039966572,-0.015394415,0.014234958,0.05852329,0.03825937,-0.025207188,0.05870682,0.017980095,-0.02988959,0.08010548,0.084455535,0.0064412607,-0.05453824,-0.063961245,0.102480635,0.037830062,-0.04835167,0.02528377,0.021469837,-0.02850444,0.0704812,-0.028792858,0.02520752,0.16383325,-0.07021907,-0.041779302,0.00088542706,0.014916422,-0.103434816,0.018014167,-0.014183475,0.04721408,0.03630289,-0.007988116,0.0074348357,-0.0029497654,0.004115682,-0.02525673,0.013410949,-0.0479684,0.024256196,0.008585567,0.00083674036,-0.039436202,0.08893087,-0.05457093,-0.019348048,0.06616163,-0.015278311,0.010538925,0.028558072,0.09594748,0.025064308,-0.0008863353,-0.112899154,-0.027989073,-0.036764633,-7.423699e-34,0.11624271,-0.005803037,0.0024263451,-0.07400148,0.0183605,0.06957153,-0.064838804,0.03709323,-0.04580818,-0.02353365,0.037128624,0.11647608,0.09285468,-0.07500805,0.045600712,0.0058943275,0.0552617,0.10786416,-0.028786087,-0.04981765,-0.0149594825,-0.037888136,-0.05465023,-0.02624817,0.01742561,0.018675031,0.00622344,0.06317862,0.0077649434,0.0059272344,0.07885322,0.04478684,-0.072045356,-0.06387267,-0.023684492,-0.00062062306,-0.10119994,-0.061867297,-0.00063929847,0.02117779,-0.06094732,0.036625847,-0.024042826,0.018618591,0.067470685,0.06331544,-0.026470294,-0.026661187,0.0030525185,0.037945688,0.029667366,-0.06436723,0.02046297,-0.033606414,0.02025379,-0.047149558,-0.025922658,0.030394556,-0.017622113,-0.043540586,0.00054849754,-0.027962718,-0.012810617,-0.008223439,0.049035452,0.083832964,0.049006797,0.08152171,0.011703648,-0.1020917,0.04227763,-0.031057976,-0.0012329805,0.029924458,0.026719568,0.037427243,-0.06316506,-0.011055818,0.028559808,-0.039556094,0.05151016,-0.02615878,0.006177017,-0.021784568,-0.029901205,0.0019702725,0.015654417,-0.023148885,-0.013457949,0.025685426,-0.07638893,0.08435113,0.00027920815,0.05925994,0.10525413,-3.0742388e-08,0.035390805,0.006576558,0.050972123,-0.005153947,0.0063153626,-0.028364113,-0.054105703,-0.010852692,0.07784899,-0.034969855,-0.016991653,-0.004951829,0.02564369,0.07460949,0.035412878,0.0011522882,0.02175716,-0.037396826,-0.027475085,0.040276185,-0.0793563,0.0065046176,-0.0529064,-0.018511092,0.04677522,-0.06360035,0.06654989,-0.033735238,0.017658679,-0.0016946739,0.025916228,0.048062358,-0.04001496,-0.0053856275,-0.06875563,0.065580495,-0.04975413,0.020563925,0.010176215,0.043410063,-0.005158869,-0.040856462,-0.053487483,0.024850864,-0.10024373,0.036894687,-0.062269762,0.026164511,-0.10753312,-0.04592018,0.023771228,-0.005458727,-0.01765784,-0.027999988,-0.11405856,0.011069013,0.026967987,-0.0060457094,0.0015589502,-0.057252366,0.004395165,-0.009433841,0.09022225,0.050113946 +1.14.11.49,"The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+.",384,0.99999994,-0.054205842,-0.036130242,-0.056295328,-0.018036762,0.100431114,-0.019500483,-0.017812947,0.04131266,0.04293747,0.016615998,0.022156581,-0.015327635,-0.07990068,0.024123292,-0.056255657,0.05017863,-0.091169745,-0.014576038,0.01611883,0.00053662807,0.048381973,-0.011118297,-0.02764201,-0.0035511097,0.048649088,0.003937786,0.07221772,0.025535895,-0.042261116,-0.07822424,0.02731932,-0.08451506,0.042736974,-0.018137526,0.053710006,0.044620804,-0.00814786,-0.035626274,0.06772528,0.02223609,-0.030957649,-0.0045906613,-0.016561097,0.068690605,-0.08410685,-0.062316246,-0.0050874283,0.025093812,0.03358321,0.031246133,-0.059344828,-0.0109120635,-0.02626483,-0.038325753,-0.009666813,-0.036797624,-0.076257095,-0.04826353,-0.060575537,0.036514036,0.011215207,-0.06336395,-0.00038448966,-0.009333936,-0.013957769,-0.0056650364,0.0441921,-0.064693354,0.081778996,-0.010045656,-0.02610131,-0.08177691,-0.014274775,0.038200013,0.007985205,0.027308716,-0.022555515,0.01922956,0.050051566,-0.036617704,-0.018022103,0.008720915,0.009084909,0.03979648,0.055108607,0.018089294,-0.023217041,0.034593575,0.040343314,0.044137325,-0.010454768,0.012104819,-0.01489588,-0.06663138,-0.017114233,0.057980362,0.038841885,0.04653038,-0.038445994,0.008350401,0.023083206,0.08671525,-0.053581987,-0.057827473,0.007085782,-0.024556972,0.016839648,0.030877545,-0.085905164,-0.0440533,0.00313074,-0.0020740582,-0.0071528037,-0.0026471256,0.02239847,0.052101135,0.03868275,-0.056587353,-0.03931737,-0.032696117,-0.014353774,-0.0059626712,-0.013183744,0.116013624,-0.1414014,0.011524264,-0.061948963,5.350621e-33,0.021324005,0.051964637,-0.035699174,0.011335338,-0.00094979955,-0.03785981,-0.046871167,0.02090015,-0.0060508405,-0.0047561456,-0.10732989,-0.106392674,0.057753626,-0.098179445,-0.042412803,-0.12654643,0.059363633,0.032927506,0.07687797,-0.01238281,0.023229208,0.12015618,0.055033263,-0.056337476,0.021440657,0.16493376,-0.11405342,-0.011803846,0.13457507,-0.008391831,-0.042238828,-0.019886846,-0.04648112,-0.028741905,0.03496691,-0.008851589,-0.11888551,-0.025624515,0.09717309,0.081515945,0.032846645,0.010234786,-0.018966774,0.017367272,0.057446804,0.06682962,-0.076365724,0.10492012,-0.008852388,-0.026952792,0.0011622655,-0.003781572,0.07121822,-0.0363641,-0.060748164,-0.07429916,-0.05583256,-0.046169035,0.013240814,0.049561717,0.06714014,0.0075135743,-0.021598313,-0.016194988,0.021929063,-0.053742327,-0.06228331,0.0465665,0.06528424,0.12729025,-0.0058746436,-0.021365136,0.07547202,0.015536171,0.07014986,0.041106932,-0.08136239,0.012220472,0.007049165,0.06446891,-0.0023556412,0.021605488,-0.044536114,-0.011375442,0.00045582754,0.047363136,-0.05370883,-0.05157947,0.00746402,0.073530786,-0.001026066,-0.050382886,-0.017754834,0.011016035,0.0013254209,-6.379608e-33,0.10798742,-0.14807434,0.016283857,-0.04371641,-0.07713834,0.08126258,-0.04055271,-0.0729502,-0.027291074,0.05227616,0.07568257,-0.06683138,-0.045160223,-0.10539868,0.015086685,0.05287996,-0.018791052,0.088524416,0.032201078,0.015248052,-0.0027130942,0.048557367,-0.01888002,0.06297198,0.045126915,0.031913802,0.021566505,-0.042142145,0.0931743,0.019102313,-0.023981465,-0.0043132673,-0.026933301,-0.048548304,0.009636677,0.03893471,-0.03171765,0.05102386,0.015563434,0.032745462,0.019217959,0.03686598,-0.004615572,0.033849213,0.025913127,-0.0030361374,-0.087826625,-0.0062309396,-0.05339852,-0.09327356,0.07822249,-0.04884165,-0.06241583,-0.030487843,-0.011094607,0.08675112,0.010600807,0.015317325,0.08539951,-0.029565888,-0.047518793,-0.097486876,0.01877597,0.007618698,0.040131714,0.08553787,-0.0823206,0.071443245,-0.057771582,-0.0036983667,-0.0012743653,0.016476933,-0.0151240835,0.029144788,0.0055366075,0.014859329,0.0055472306,-0.063308254,0.011966508,-0.035119377,-0.08300718,-0.023309875,-0.025772544,-0.0022756234,-0.027318606,-0.04297753,0.13651821,0.07446007,-0.005854577,0.022417376,0.00089698285,0.013065951,-0.021163974,0.08608968,0.06474211,-4.20564e-08,0.029270949,-0.037407946,0.013839831,0.016077954,-0.0003585001,0.052914962,-0.07214136,0.003783315,-0.013780352,-0.053280942,0.007874403,0.099953175,0.082020156,0.008570442,0.016661135,0.024697501,-0.03731026,0.031873003,0.047615524,-0.016609529,-0.079205796,0.028989963,-0.07752503,0.01459766,0.010918245,-0.035297193,-0.043196317,0.05268334,0.034489375,-0.0402656,0.04344152,-0.033002757,-0.0029069409,-0.056973394,0.041206714,-0.031798713,-0.033907015,-0.12807651,-0.00865355,-0.035190724,-0.008556911,0.0025271766,-0.023265192,0.059638012,0.004548018,0.0042782375,0.009534855,0.044968214,-0.048257295,0.056653187,0.034190387,0.03395817,0.017896345,-0.047782663,-0.053133648,-0.063631065,-0.019339144,-0.08198151,-0.061739802,-0.0485424,0.0037262319,0.017286174,0.17118593,-0.053621184 +1.14.12.24,"This enzyme, characterized from the bacterium Burkholderia sp. strain DNT, is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It does not act on nitrobenzene. cf. EC 1.14.12.23, nitroarene dioxygenase.",384,1.0,-0.063379526,-0.02546725,-0.11565126,0.00523776,0.08166615,0.013999606,-0.058709472,0.016934296,0.056778796,-0.11327495,-0.0553435,-0.058405336,-0.040718686,-0.01910903,-0.096233785,0.0138369035,-0.042805746,0.021592446,0.0037703493,0.04856927,0.031185502,0.05424108,0.04375834,-0.02018971,-0.014853757,0.023964917,0.11496819,-0.028043712,-0.053013477,-0.10149587,0.027777923,-0.030014435,0.008528442,-0.04281372,0.0294998,0.1069021,-0.026629496,-0.027137702,0.009313298,0.04705762,0.023900667,-0.0037877383,-0.032781098,-0.016833264,0.004426879,-0.033847243,-0.026343001,0.04693922,0.07409023,-0.0102389725,-0.10381512,-0.07448715,0.022358514,0.08993842,0.06936908,-0.048332803,-0.006487122,-0.067591496,-0.034549773,0.0063642855,0.065486096,-0.018509964,0.034382254,-0.005192761,-0.003807077,-0.029174823,0.014536201,-0.042378694,-0.0126244575,-0.11691828,-0.04069453,0.015522633,-0.046828445,0.05727183,-0.032055147,0.055568594,0.053953942,0.043860495,0.058424722,-0.030460292,0.063521214,0.047763284,0.115974985,0.10314627,0.03855668,0.01592048,-0.05459273,-0.0058439462,0.013829261,0.04865939,-0.008284505,0.062784985,0.028117267,-0.023502624,-0.030434726,-0.008807704,-0.031220218,0.033779494,-0.005614575,0.0075306394,-0.05665052,0.088087134,-0.03429945,-0.06317045,-0.09571499,0.0013338134,-0.03272425,0.078408375,0.072800145,-0.00080546894,0.02681156,-0.021259736,0.06957464,-0.009598963,-0.007655528,0.048857782,0.039389748,-0.05049494,-0.09198354,0.0044329828,0.025655633,0.0130277425,-0.005006535,-0.025524769,-0.063686274,0.05811413,-0.09038634,4.093814e-33,0.06932523,0.027151993,-0.06727284,0.02873483,0.03660658,0.002708883,-0.11608971,-0.0058776382,-0.029160755,-0.044982057,-0.048004832,-0.048054673,-0.0010771727,-0.104591206,0.011746424,-0.037493914,-0.004406181,0.03522007,0.05001998,-0.00013961233,0.044619493,0.04729121,-0.04512958,-0.002535178,0.009593133,0.0521657,-0.018496338,-0.020930963,0.013189499,-0.029937858,0.08180331,-0.0993485,-0.084030345,-0.041468505,0.010559634,-0.07442258,-0.02498825,-0.001145834,-0.06253028,0.039282482,-0.05358853,0.06188474,-0.050842285,-0.08415956,0.08328816,-0.11873042,-0.056322865,0.15190911,0.096080884,0.106702045,0.006452416,0.008696174,0.10982769,-0.011822908,-0.09255035,-0.001650487,-0.0037333297,0.0043774373,0.10146793,0.05086888,0.0101418365,0.07656817,0.023310926,0.017845098,0.024369363,-0.009438202,-0.07577645,0.00020156083,0.03792457,0.10665194,-0.0012108436,0.028066233,0.054261435,0.009631349,0.008983111,-0.10921822,-0.085835636,-0.038909525,0.07006549,0.008034682,0.03517088,-0.0055393744,0.0103164185,-0.03692306,-0.028702509,0.03834364,-0.062381536,-0.015466844,-0.0632148,0.021566212,0.051443625,-0.05890777,-0.09376491,-0.0750506,0.028403431,-3.221495e-33,0.10670864,-0.067070976,-0.026484037,-0.07275725,0.024696734,0.07995022,-0.0019091729,0.035146084,-0.02708946,0.0014359176,0.08618698,-0.020113146,0.028984532,0.0071714963,0.043187164,0.020676525,-0.039597455,0.04598366,-0.014811235,-0.03524458,0.029027993,0.03968081,-0.017536325,0.053034965,0.014952768,0.0127810165,-0.026307045,0.06980287,0.08843301,0.050910104,0.022699807,0.025580972,-0.04866131,-0.020109786,0.014326468,0.061696723,-0.057207953,0.019049754,0.017039156,-0.0035997804,0.00036398,0.0077690133,-0.03972132,0.07149709,0.02584816,0.08127295,-0.10582214,0.007775918,0.06999986,-0.021204604,-0.015371325,0.021580152,-0.0051721185,0.053514805,-0.02460298,0.011149326,0.018117938,0.032457374,-0.04728516,0.0040800935,-0.01935734,-0.05752385,0.033191916,0.024327386,0.04264138,0.0235817,-0.030961245,0.08619673,0.08583857,-0.041864473,0.053303853,-0.024988843,0.09580579,0.022365402,-0.034191895,0.012746088,0.012720926,-0.0057212724,0.009820518,0.008972674,0.02817329,-0.009555609,0.01850393,-0.050958745,-0.0056382995,-0.09457748,0.052998863,0.022131702,-0.007591741,0.01370208,0.017934904,-0.0039864145,-0.04009589,-0.006456833,0.019817436,-4.536847e-08,0.037047975,-0.13847855,0.062510096,0.01925884,0.013228074,-0.03266183,0.017058387,-0.03959568,-0.04969218,-0.00080383447,0.030746743,0.094093174,-0.017652957,-0.0299383,0.080446206,0.027312005,0.020010235,0.04241632,-0.024106994,0.008584536,-0.02760794,-0.0038578429,-0.07935038,0.039314367,-0.0008687923,-0.08342058,-0.04996051,-0.047884904,0.06583181,-0.03342227,-0.006307921,0.06418405,0.053661592,-0.03741664,-0.095975555,-0.0030519327,-0.083967894,0.030826835,-0.031700004,-0.015438956,-0.027140735,-0.013445162,-0.05115754,-0.0135114305,-0.03925823,0.004845849,-0.028603826,-0.018468972,-0.018702744,-0.032885004,0.026373949,-0.022112409,0.05422861,0.00766034,-0.11966053,0.11701244,-0.015720192,-0.037076563,0.036962762,-0.052331634,0.004092118,0.024929717,0.1693494,2.0578645e-05 +1.14.13.206,"This plant enzyme is involved in the synthesis of sporopollenin - a complex polymer found at the outer layer of spores and pollen. It can also act on decanoate (C10), myristate (C14), and palmitate (C16) with lower activity. The enzyme also produces a small amount of products that are hydroxylated at neighboring positions (C-6, C-8 and C-9).",384,1.0,-0.060959347,-0.03958903,-0.05348334,-0.037053913,0.083844475,0.052786343,0.015435614,-0.0018582771,-0.00417005,0.011115327,0.09333213,-0.023306841,-0.093140945,0.037888985,-0.08980713,0.05335218,-0.08680542,0.02780745,0.011358967,0.016332142,0.03219196,-0.019132653,-0.045577448,0.051036652,0.03999152,-0.012368363,-0.018384574,-0.03917282,-0.0015774155,-0.023423396,-0.011550813,0.07729351,0.03910489,-0.039047513,0.017400581,0.07893991,-0.018110923,-0.01856086,0.10297058,0.0109526105,0.04080104,-0.026742278,-0.0198618,-0.06812913,-0.025911156,-0.02043524,-0.014477519,0.072307214,0.030520326,0.0018464692,-0.074017935,-0.027403405,-0.014928142,-0.050422326,-0.0044868165,-0.0035687292,-0.028773718,0.05506409,-0.0058676302,0.028962865,0.06947764,-0.06886177,-0.04730151,0.010547453,-0.02238846,-0.07765105,0.037018508,0.002014645,0.04403506,-0.006534857,-0.008735619,-0.040327746,0.042753965,0.051179364,0.01445192,0.061721724,-0.051662058,-0.045731172,-0.03276538,-0.01786226,0.09743583,0.05511215,0.005257549,0.059061173,0.045414846,0.0016289488,0.02668606,0.061262235,0.033668846,0.03182309,0.057412192,0.053261884,-0.094442934,-0.04571142,-0.11411751,0.11630929,0.0046308865,-0.0074886014,-0.00530356,0.028600765,0.0123601435,0.004032211,0.0040132273,-0.15725416,-0.017717237,0.012780082,-0.10886973,-0.020386435,0.013117304,0.046953216,-0.043212526,0.018297983,-0.021632291,-0.0015725219,-0.032990254,0.062060148,0.032764293,-0.034676276,-0.05549121,0.013437799,0.0051273615,-0.05692073,-0.038611796,0.0468592,-0.02765237,-0.032375813,-0.07055274,-1.7451345e-33,0.07662097,0.024299325,0.020472107,0.056366447,0.015767613,-0.047459695,-0.04557115,-0.001719595,-0.13812014,-0.060947545,-0.1020588,-0.11137304,0.005930456,0.027288558,-0.036878396,-0.045124378,0.010557982,-0.006927085,0.042114336,-0.026828943,0.0046115434,0.056460384,-0.12595241,-0.027419206,0.032077134,0.043765936,-0.015734166,-0.053725492,0.04156479,-0.03708233,0.06717157,0.00092230894,-0.07989361,0.08824154,0.087177604,0.0068127373,-0.03593042,-0.11525525,0.0005149746,0.0800964,0.015985593,0.017116748,0.08581047,0.011838171,0.010063491,-0.021271057,-0.017366463,0.03678587,0.118910514,0.067705534,0.07073713,-0.02388746,0.07427991,0.032466274,-0.053926364,0.053916924,-0.027940843,-0.02423929,0.06593106,-0.019379368,-0.015320651,-0.02451346,-0.08121797,0.014834682,0.008042848,0.0017196116,-0.08280226,-0.06306036,0.039857052,-0.03289164,-0.05248353,-0.06263344,0.0074075577,0.03786229,0.06331936,0.029504715,-0.04931577,0.015796963,-0.04513941,0.034131452,-0.010878181,-0.029759534,-0.03601649,-0.01599292,-0.100739114,0.009816119,-0.062437132,0.026659608,-0.005367678,-0.045330174,0.047664065,-0.10323032,-0.07527482,-0.038977265,-0.015525171,-5.281894e-34,0.034612823,-0.1181902,0.076717936,-0.035670675,-0.1112887,0.07334065,-0.003117034,-0.058370806,-0.029467368,0.015403617,0.021987487,-0.0154043045,0.034581944,0.00057664426,-0.07357996,0.092623316,0.06029662,0.031923365,-0.03329775,-0.04116562,-0.059283704,0.081231445,0.03016427,0.052406892,0.011323782,-0.0128078675,0.06361025,0.05950503,0.088771574,0.061745014,-0.038952097,-0.06875578,-0.03436261,0.014392303,0.009283207,-0.017016966,-0.059408303,-0.021995056,-0.014238692,-0.0013233457,-0.051353447,0.003621462,0.036791462,0.070404336,0.0856789,0.023257453,-0.062068235,0.042717364,-0.02474368,-0.0025622996,-0.021967651,0.05926615,0.028853219,-0.008730956,0.083523504,-0.039079897,-0.0015800326,-0.050778292,-0.0027673969,-0.044629335,0.033209212,-0.02561467,-0.052765217,0.035163473,0.06336816,0.13834012,-0.089496724,0.033458684,-0.024157654,-0.06266482,0.04335607,-0.0071301665,0.012454086,0.0764627,-0.04830705,-0.08013637,0.009426366,-0.017884852,-0.007587543,0.0054341536,0.011297484,-0.027122788,-0.011282897,-0.027579103,0.009989049,-0.029855315,0.038912993,0.033907782,0.024692025,-0.012973454,-0.0038609274,0.070121184,-0.024510117,0.047552194,0.08291545,-4.007628e-08,0.03957029,-0.06910353,0.08596043,-0.111119166,0.0036393984,-0.009928639,0.043218497,-0.024440194,0.04045521,-0.087463096,-0.09123764,0.037774555,0.03558219,-0.034036815,0.058497235,0.03464925,0.013500699,0.029603146,-0.0683017,-0.010011985,-0.010569753,0.0027842664,-0.14328745,0.026086552,0.03752577,0.02336483,0.0433318,0.09720964,0.056534547,-0.0010720113,0.020600386,0.003549066,0.02292758,0.015978815,-0.078288026,0.07789683,-0.008713131,-0.039122857,-0.003804821,0.028337495,0.014219407,-0.04979851,-0.020602498,-0.017984882,-0.03862237,0.0027633985,-0.004991627,-0.0039502033,0.07857696,0.090547815,0.093086496,0.09495413,-0.04371213,-0.027578045,-0.1096271,-0.011540681,0.028193409,-0.032267228,0.033673596,-0.032621402,-0.04711645,0.0205103,0.11762345,0.051230177 +1.14.13.207,"A cytochrome P-450 heme-thiolate protein. Involved in the insect aggregation pheromone production. Isolated from the pine engraver beetle, Ips pini. A small amount of (S)-ipsdienol is also formed. In vitro it also hydroxylated (+)- and (-)-alpha-pinene, 3-carene, and (+)-limonene, but not alpha-phellandrene, (-)-beta-pinene, gamma-terpinene, or terpinolene.",384,1.0,-0.051671363,0.0069476883,-0.006931359,-0.0039608628,0.047322016,0.06298575,0.026965145,0.044994567,0.04129218,0.019312736,0.054039888,-0.00029570208,-0.06342144,0.025424592,-0.04901753,0.053171236,-0.051031783,-0.0032424459,0.012813832,-0.0526008,0.017058719,0.019594684,0.0023239497,0.011410405,-0.07087849,0.0021989236,0.0003138722,0.020050751,0.0025114121,-0.04882495,0.0056746807,0.040575698,0.056197967,0.004793669,-0.053725522,0.06618015,-0.058362175,-0.06571294,0.0949095,0.016938634,0.08688585,0.00040429085,-0.051192474,-0.05707949,-0.113211036,-0.038729474,-0.0013100369,0.0711838,0.052575603,-0.091460966,0.0033069835,-0.058131054,-0.01632404,0.06687817,0.0061026993,0.009141745,0.04299103,-0.10726548,-0.026412891,-0.008870694,0.017277785,0.08979244,-0.031084843,0.018350638,-0.0035725343,-0.026002496,-0.07428418,0.05698085,0.044924475,-0.04337858,-7.209233e-05,-0.033943955,-0.0543149,0.062470097,-0.012592098,0.08790671,-0.053898375,-0.010803922,0.04975388,-0.08483154,-0.07919993,0.0034888338,0.006286579,0.12780201,0.050070327,0.005420251,-0.04786968,0.109050974,-0.058918666,0.0042549614,0.013790448,0.008978404,-0.045794856,-0.026064781,-0.03576777,0.0033570982,0.036518604,-0.04420984,-0.041358456,0.045390137,-0.009939245,0.037869427,-0.028494112,-0.14966054,-0.10240961,0.022576574,-0.032063164,0.01297845,0.081370726,-0.026841467,-0.0577721,-0.08452186,0.03157609,-0.0013321841,-0.043334085,0.022174414,-0.044968933,-0.019095346,0.08015809,-0.07372567,-0.007116349,0.008428023,-0.0009110257,0.01779231,0.009133257,-0.017526343,-0.07868589,-4.5433187e-34,0.08321946,0.051717453,-0.026956514,0.019741414,-0.029942462,0.036678456,-0.050454993,0.014351706,-0.0115785785,0.008381692,-0.071404204,-0.063498534,-0.0017625224,-0.014203623,0.015668597,0.009217489,0.0048319967,0.07965404,0.119896814,-0.004226907,-0.08928378,-0.01957787,-0.06406181,-0.06118279,0.053378884,0.07805757,-0.0389356,-0.046830993,0.036409482,0.009048088,0.07870244,0.031538304,-0.041380927,-0.001239712,0.022602305,-0.020322572,-0.04076941,-0.07550236,-0.07062276,-0.007163114,0.03758331,-0.056809545,0.008331325,-0.036429714,0.024314234,0.0010657473,-0.16963044,0.011832374,0.0671347,0.013128424,0.026103731,0.00918573,0.12549077,0.022266356,-0.07604922,0.0006782172,0.019214228,-0.006760851,0.012925296,-0.013100311,0.044237833,0.081458285,-0.030165263,0.0002970801,0.05996265,0.055522222,-0.06141475,0.0037786355,-0.10318459,0.07133697,0.0072076367,-0.018646544,0.009919256,-0.06209972,0.037216514,0.020136723,-0.018305054,0.035936076,0.018413521,0.020934775,-0.054180317,-0.055604924,0.021199487,0.0002235905,0.005431026,0.024687877,0.079224184,0.006187982,0.034207653,0.09373351,0.017873866,-0.092359394,-0.06440388,0.019997744,-0.033291582,-6.1531097e-35,-0.05495847,-0.062453963,-0.022903787,-0.100846685,-0.0061468617,0.057752974,0.0017119179,0.0008895152,-0.03541558,-0.009789881,0.07868499,0.011402253,-0.006359416,-0.044487655,0.016843863,-0.0005729382,0.016477745,0.058397572,0.05118183,0.036306113,-0.012590397,0.0040751086,0.047960386,0.032419972,0.00796363,0.0094137695,0.10503601,0.07591269,0.04628649,-0.016378008,0.11913046,0.050440114,-0.027328711,-0.08957375,-0.040876158,0.03760477,0.024286374,-0.06378645,0.08891808,0.0658851,-0.059547495,0.015233,0.0442537,0.03540906,0.07590848,0.066271335,-0.04924284,-0.050625797,-0.009800169,0.01331962,0.060291443,0.038346577,-0.003485998,0.0045685354,-0.05864783,0.011314622,-0.035421465,0.017120117,0.0399395,-0.14888743,-0.061463468,-0.055332925,-0.042896457,0.075471364,-0.025848368,0.008552281,-0.035477847,0.064059794,0.02291477,-0.03876031,0.05683342,0.0422024,0.08391132,0.0939945,-0.013628,0.01452401,0.09517025,-0.056116734,0.052300412,-0.020214003,-0.020051667,0.020584593,-0.04979913,-0.046282057,0.0112830885,-0.059929833,-0.027879007,0.14035611,-0.020670628,-0.0378454,-0.006433895,0.10744483,-0.011238094,0.049523294,0.0710661,-4.1972886e-08,-0.006972793,-0.08114696,-0.007856248,-0.035328288,0.0256537,-0.018215736,0.021591509,-0.03514795,-0.011110648,-0.04252525,-0.0018515157,0.034781583,-0.028422711,-0.005690781,0.0568571,-0.01590365,-0.018424217,-0.0031196002,0.007851061,-0.028174752,-0.0065031485,0.061342053,-0.0144164525,0.010372412,-0.029874085,-0.06827126,0.063844904,-0.07667327,-0.024289519,-0.009982839,0.056296643,0.12619738,-0.026373144,0.041549962,0.04217131,0.08077689,-0.09230696,0.0040728436,0.0018778049,-0.037342012,-0.010516721,-0.029054679,-0.08376516,-0.043102663,0.042183667,-0.07274253,0.031827558,0.07786246,-0.0055661113,-0.04992398,-0.041453224,0.098177664,0.0111348955,-0.05826574,-0.05057923,-0.06542193,0.017441655,-0.069353215,-0.0036859217,-0.058369532,0.0314652,-0.080005296,0.12513869,0.035714418 +1.14.13.208,"The enzyme is involved in aerobic benzoate metabolism in Azoarcus evansii. BoxB functions as the oxygenase part of benzoyl-CoA oxygenase in conjunction with BoxA, the reductase component, which upon binding of benzoyl-CoA, transfers two electrons to the ring in the course of monooxygenation. BoxA is a homodimeric 46 kDa iron-sulfur-flavoprotein (FAD), BoxB is a monomeric iron-protein [1].",384,1.0,-0.051705692,0.011010325,-0.09645823,0.039742287,0.073675275,0.031042239,-0.048692,-0.01591251,0.030509042,-0.05330125,-0.05591713,-0.02281158,-0.084717445,-0.024203574,-0.11672742,-0.009214415,-0.086774714,0.022689521,-0.09261834,-0.032260425,-0.025378322,0.083975896,0.0140416045,-0.002251536,-0.046938043,-0.08530927,-0.005651624,-0.010915896,-0.05878981,-0.07224358,0.09899738,0.014283244,0.07288188,-0.012090674,-0.018870778,0.084231734,0.018686872,-0.12145582,0.014849518,0.0035811216,-0.019202815,0.038672633,-0.005739025,0.03412723,-0.017992286,0.018081587,0.044158433,-0.039890446,0.010590656,0.011362946,-0.0065384367,0.008808448,-0.102951966,0.084528476,-0.051980145,0.019198889,0.024587989,-0.0343364,-0.028529426,0.024101852,-0.009024292,0.052164875,0.023754193,0.018517843,0.030994378,0.010798759,-0.0675712,-0.023266317,-0.07041912,-0.11698193,-0.047389153,-0.054951202,-0.08481753,-0.019512733,-0.026841758,0.0073491875,-0.04408963,-0.029290807,0.09767034,0.01869152,-0.02193377,-0.03180037,0.016432399,0.07221157,0.0030826312,0.00966099,-0.07622728,0.01137359,-0.008594426,0.056348983,0.046975218,0.028676072,0.00589013,0.019132193,-0.060343675,-0.011759888,0.033254687,0.026096279,-0.051811185,-0.0018107159,-0.014257933,0.0050871675,0.02788202,-0.09067027,-0.084361136,-0.06656622,0.011246029,0.10236905,0.021548565,0.022310603,-0.01672699,-0.012977,0.055873897,-0.0043402873,0.05710492,0.08314974,0.02286096,-0.061534546,-0.077640094,-0.031495545,0.027338032,-0.022577096,0.04281266,-0.0038719135,-0.032043133,-0.005605979,-0.10813814,3.40179e-33,0.0815043,-0.03281243,-0.01909263,0.030794056,0.017177925,-0.008287163,-0.09159754,-0.021738527,-0.025069464,0.03017636,-0.11832813,-0.0009396594,0.056698307,-0.07431114,-0.016861558,-0.027505167,-0.0893527,-0.003995922,0.05078166,0.019662663,0.03929325,0.030989315,-0.030257681,0.051131357,0.061518367,0.06141668,-0.020105714,-0.010795224,-0.026834607,0.027489891,0.012948375,-0.093609415,-0.1542202,-0.047278408,0.013029958,-0.011228052,-0.042521466,-0.023486754,-0.09740168,0.078968644,0.07921761,-0.016302485,0.015802462,0.010578737,0.07937922,-0.045421015,-0.072034486,0.16983981,0.025441214,0.040955007,0.013391934,-0.042742714,0.078333214,0.06578535,-0.002974704,0.06095991,-0.06583102,0.0760566,0.06892999,0.06464663,0.09345614,0.04377463,-0.033507302,0.047946513,-0.016981646,0.03084821,-0.11979002,0.004021772,-0.07589582,0.087797984,0.050623897,-0.033246376,0.03369703,0.030987458,0.02634809,-0.0574035,-0.028876705,-0.017780125,0.010022117,0.01032271,0.0019190991,0.01080528,0.0036889438,-0.05249798,-0.07364267,-0.046568993,0.019931942,0.013438888,-0.03863987,-0.021099018,0.12068975,-0.046381216,-0.007475586,-0.028013075,0.046120282,-3.4907157e-33,0.05345544,-0.08048376,0.065166175,-0.08866889,0.05951718,0.003586424,0.07733143,-0.053149622,0.048914526,-0.00910153,0.011839441,-0.0014744878,-0.03668221,0.0015135205,0.055309173,0.017095596,0.007533344,0.029211279,0.043015763,0.024324698,-0.06723153,0.011126018,0.014144593,0.0025437584,-0.043454748,-0.02258505,-0.028116547,0.07663931,0.013247207,0.022504114,0.04981756,0.05925362,-0.07174553,0.003670429,-0.10432532,0.085083015,0.013048129,-0.02236475,-0.0019818018,-0.0064719655,-0.0348692,-0.032284413,-0.046703786,0.1096317,0.064619385,0.03351462,-0.15415168,-0.009560365,0.016345719,-0.02183795,0.0064690667,0.026885092,-0.010855874,0.033776782,0.023653299,0.09500342,0.032639187,0.034252882,0.022848615,-0.011512666,0.019845763,-0.04261234,0.07240645,0.037103906,0.029908568,-0.0025800795,0.04069568,0.05393363,0.011877843,0.004279423,0.09516444,0.027267283,0.009814654,0.07324219,-0.04994839,0.02133039,-0.0027749897,0.022402015,-0.018453252,0.032323048,-0.049078047,0.00863192,0.0363492,-0.034554634,-0.006913143,-0.110641055,0.0051651066,0.056186054,-0.011721322,-0.032113366,-0.057951555,-0.046210878,-0.033460997,0.044701852,0.06072186,-3.521041e-08,-0.06524153,-0.080156796,0.011102232,-0.01848742,-0.02781573,0.079990685,0.019284649,0.0328888,-0.006425513,-0.07369568,0.016180197,0.076244146,-0.008963407,0.017767606,0.077408165,0.035805363,-0.038724344,0.052481808,-0.0030692427,0.06163744,0.055928536,0.025106065,0.0046551973,0.03371009,-0.06062971,-0.08142238,0.0094177425,0.039187796,0.03563502,-0.024206012,0.001558035,0.08317018,0.08389909,-0.012241764,-0.098501146,-0.00674799,-0.011584721,0.01171239,-0.10348448,0.041039877,-0.017038623,-0.07575428,-0.065345116,-0.06881991,0.06854982,-0.0250248,-0.0072862804,0.041665066,0.021482147,0.012504152,0.07547361,0.03327148,0.022787035,0.04311488,-0.015248585,0.021826398,-0.030225502,-0.03338037,0.08076849,0.019264631,-0.04689686,0.035991654,0.09970053,-0.07498912 +1.14.13.209,"The enzyme, characterized from the bacterium Streptomyces sp. WA46, participates in a pathway for salicylate degradation. cf. EC 1.14.13.172, salicylate 5-hydroxylase.",384,0.99999994,-0.025050007,-0.018544791,-0.07484062,0.03265438,0.06698646,0.07131646,-0.007945646,0.0073324265,0.04136783,-0.022448543,-0.034101944,0.0030385782,0.014527528,0.06857762,-0.07672471,0.04818749,-0.12417315,-0.016086677,-0.014210038,-0.007353079,0.13535902,0.061655838,-0.0024008977,-0.01303383,0.10096688,-0.010326334,0.021987472,-0.012291925,-0.08281354,-0.073539525,0.045605738,0.023073409,0.09798799,-0.033349905,0.12336035,0.13024142,-0.0057011745,-0.10710121,0.054798618,0.050354082,0.0023710064,0.0012685172,-0.019341039,0.029380985,-0.073026635,0.018285105,0.03314962,0.04309648,0.012539974,-0.030645937,-0.102448605,-0.07486468,-0.062925085,-0.0135042295,0.006518206,0.036588144,-0.0020213719,-0.0435501,-0.04260096,-0.042121146,0.044765282,-0.017428037,0.016335607,-0.0429905,-0.03886877,-0.04952175,0.059999537,-0.12167821,0.04835757,-0.030197311,-0.16340193,-0.065177396,-0.014314688,0.026125936,0.037721828,-0.025635986,-0.0035962546,-0.06420582,0.0055590933,-0.049630474,0.041424558,0.00919837,0.004115985,0.04541556,0.0709158,-0.04808363,0.041174654,-0.041121196,0.090408556,-0.032697935,-0.014189844,-0.03485082,-0.012073985,-0.029674381,-0.06738575,0.009820546,-0.05637268,-0.028936801,0.013968812,0.011651719,-0.016490722,-0.0010853523,0.01013534,-0.05917762,-0.014930153,0.029509634,-0.043847762,0.13866109,0.005399408,-0.0586806,0.016928097,0.030595416,0.020634394,0.007700275,0.07101101,0.064538166,0.023416644,-0.06815633,-0.067811005,-0.022723464,-0.027063526,-0.03775679,0.050520927,0.009794326,-0.08007222,0.08205315,-0.113626525,-3.994993e-34,0.03359243,-0.002015418,0.015437963,-0.038742963,-0.019961372,-0.037967596,-0.030267244,0.023712886,0.013315547,-0.11012854,0.005332288,-0.067871094,0.022561401,0.01388959,0.02647846,-0.041743357,0.0032485034,0.062572084,0.035947353,0.025469664,-0.023630591,0.065970674,-0.031236447,-0.03589993,0.041302606,0.05879973,0.01889531,0.0047592255,0.059006307,-0.015747216,0.0410814,-0.06891456,-0.11500992,-0.010548264,0.08302499,-0.0144973565,-0.051028,-0.0032655457,0.048258215,0.05167826,-0.035038743,0.05725342,0.04133089,0.017131258,0.04429498,-0.045125287,-0.0007707312,0.124693446,0.048920747,0.04600762,0.012981453,-0.018070837,0.11962952,0.0025835014,-0.07878134,0.025620287,0.02655021,0.011118559,0.002692096,0.00453094,0.016447404,0.009442394,-0.0070624594,0.008701381,0.046181325,0.03698053,-0.017618908,0.0016830609,0.043558188,0.11473201,-0.054692764,0.03343589,0.034389477,0.03410719,-0.019850684,-0.071668245,-0.069357164,0.054930273,0.06846161,0.035596322,-0.026991354,-0.015353314,-0.029349899,-0.032952763,-0.08698498,0.030364161,0.015918007,-0.09024739,-0.020804638,0.06202635,-0.004508462,-0.07020324,-0.051719815,0.035371173,0.012882596,-4.001263e-34,0.13404487,-0.081781834,0.008963757,-0.015616983,-0.11795772,0.039255228,-0.005492439,0.04940492,-0.090166055,-0.053570613,0.08235911,0.004415718,0.04983366,-0.040050264,0.011571925,-0.038510524,0.020255055,0.060737118,-0.051816083,0.047364343,0.03141059,0.077066764,0.005148642,-0.00222959,0.046133038,-0.011156786,-0.012503887,0.036209006,0.055103388,0.010768763,-0.0032500494,0.0085450495,-0.050056443,-0.06475321,-0.06048404,0.012474998,-0.056657717,-0.0051765735,0.00021228142,-0.021061182,0.09673937,0.025216842,0.034685396,0.08822274,0.033575762,0.10230897,-0.066367984,0.067947574,0.0018991062,-0.06635199,-0.03321482,-0.016442006,-0.00026823502,-0.032406602,-0.06438206,0.054953706,0.0071187215,-0.05198982,-0.06521503,-0.04674981,-0.05970995,-0.002258948,0.04859088,0.04822608,0.07096021,0.026386734,0.002280425,0.038789574,0.06532525,-0.052812252,0.04631761,0.0062940205,0.03687809,0.06514381,-0.03302676,-0.0061300737,-0.12847266,0.052343577,0.012267879,0.00262169,0.035001475,-0.05196533,-0.03543978,-0.077807136,0.00444329,-0.05802652,0.040807623,0.040364336,0.03275582,0.051778026,-0.014597597,-0.033018444,-0.061322372,0.009763072,0.02727074,-2.7823539e-08,0.029056592,-0.024464611,0.05930351,-0.049991377,-0.004302317,0.021690112,0.0020122349,0.026749717,0.066780806,0.014609472,-0.048792064,0.031451516,0.0102612665,-0.005772236,-0.051753383,0.013394638,-0.044821307,-0.003933342,-0.00027377874,-0.021597993,-0.09392577,-0.06456489,-0.033254806,0.13391829,0.041584633,-0.048724912,0.0708393,0.07618955,-0.02443363,-0.043676376,0.010496937,0.0059737633,0.026824534,0.015374361,-0.021562016,0.045947626,-0.015685821,-0.048558637,-0.00091137626,0.10624846,0.008144928,-0.012356741,-0.09141874,-0.009113955,0.016750876,0.03156814,-0.010103357,-0.023347978,-0.03887681,-0.058493268,0.06238767,-0.0058886744,-0.049429003,0.0016697336,-0.10887213,0.025661362,0.013133365,-0.057720423,-0.017498886,-0.0059325835,0.06228843,0.041106176,0.14019826,-0.06818926 +1.14.14.16,"A P-450 heme-thiolate protein responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase.",384,0.99999994,-0.06397074,0.036462158,-0.05007766,-0.042565513,0.03420835,0.036078155,-0.03836201,0.05859306,-0.014905943,0.004903474,0.013085831,-0.0008304851,-0.06588755,-0.037920464,0.018382378,0.027511807,-0.03758169,-0.007985696,0.03938042,-0.052685026,-0.021206511,0.0015264045,-0.024222152,-0.029297685,0.02755445,0.001780549,0.043765027,0.08836442,-0.08386213,0.0077925883,-0.020814097,-0.027314708,-0.018289944,-0.03349648,0.023853485,0.12298519,-0.13064592,-0.06984247,0.040884722,0.01824395,0.106070794,-0.07206613,-0.10354441,0.034675624,-0.00055722456,-0.009177156,0.010470105,0.08466208,-0.020528086,0.038250666,0.017394096,-0.051234633,-0.036808804,0.07591366,-0.03421893,-0.035883836,0.024858788,-0.020147812,-0.009408979,-0.03232922,-0.0852451,0.037897177,-0.053780194,0.0017840883,0.035057515,-0.04498037,0.032060757,-0.017559594,-0.085458085,-0.07856191,0.030503206,-0.008848706,-0.009318962,0.036197662,-0.032335203,0.076504774,-0.052319113,-0.031423595,0.018351635,-0.009073079,0.05865796,0.011979626,0.020118149,0.112275876,0.06892647,-0.026076034,-0.034623828,0.02497581,-0.06080086,-0.015024267,-0.06706334,-0.094792776,-0.004981592,0.06361757,-0.102353,0.08541555,-0.051619723,-0.00054474635,-0.031248285,-0.016309282,-0.03238283,0.087254785,-0.031634748,-0.08099294,-0.098815836,0.04760064,-0.0050966,0.058238216,0.03302459,-0.02342671,-0.031347614,-0.052068885,-0.0019414509,-0.01878307,0.06448056,0.09825158,-0.03419147,0.03634143,0.009140222,-0.14433794,-0.0082090255,-0.005097368,0.06050344,0.0092538055,-0.036094088,-0.019977644,-0.066911764,2.9940073e-33,0.12615605,0.019422982,0.036061555,0.051105253,-0.04262038,0.13070288,-0.068980634,0.041238982,0.003798074,-0.086559705,-0.06548731,-0.10515452,0.05746915,-0.06304282,-0.020938102,-0.08461836,-0.011861428,0.031230094,0.11044036,0.017900107,-0.052234415,0.076106995,-0.073776506,0.034127668,0.00423351,0.09736153,-0.017353883,0.081649534,-0.0016877473,-0.009340508,-0.05651673,-0.0695507,0.02540226,-0.022263454,-0.007954105,-0.041333042,-0.042150885,-0.018810945,-0.017798604,0.042799324,0.006398275,-0.041015897,0.0031554962,-0.08390462,0.04306572,-0.011479125,-0.021446375,-0.015212357,0.0544828,0.020749394,-0.0014594079,-0.013972929,0.116916835,0.013644145,-0.09889678,0.029488306,-0.034059007,-0.01584759,0.0087155355,0.052898683,0.093650416,0.028889358,0.041612014,-0.0011454781,-0.008318663,0.060728334,-0.009469623,-0.051759064,-0.038025927,0.16358477,-0.05691704,0.056915935,0.06745,-0.03389467,0.039608244,0.03761483,0.013385819,0.08153588,0.03027351,-0.07549632,0.024729813,0.0349456,-0.02449982,0.053638123,0.036403026,0.011714237,0.00704642,-0.01706008,0.06187969,0.039238773,0.07964565,-0.07385462,-0.033579428,-0.002458331,0.010742318,-3.2378632e-33,0.056217864,-0.072144836,0.004511132,-0.082214445,-0.030431526,0.06755522,0.07656475,-0.036982846,-0.013612625,0.037622172,0.09234464,-0.058708277,-0.033762123,-0.09706155,0.03356289,-0.025323775,-0.09585093,-0.004468227,-0.026093177,-0.0056497697,0.039277837,0.09285824,0.029442748,0.01783875,0.06336618,-0.007923352,0.0030648466,-0.030357251,0.1295559,0.058047265,-0.072393954,-0.005032801,-0.06988879,-0.0066457014,-0.03271621,0.09669042,-0.03330488,0.077177376,0.021266513,0.012705708,-0.0439843,0.02739694,0.01686108,0.04188899,0.043034304,0.10637225,-0.031964052,-0.0056887115,0.031347513,0.033504922,0.0127929505,0.0028981755,-0.07823655,-0.0043914244,-0.02038055,-0.01200052,-0.00027816265,-0.014442706,0.03879283,-0.0929362,-0.04875366,-0.022409856,0.017416632,0.0070734825,-0.024022974,0.026757387,-0.04793729,0.011814558,0.0099774,0.06802808,0.06478617,-0.012684473,0.042781863,0.08588599,0.024185797,-0.072454214,-0.00509777,-0.011876555,0.003937187,0.034017585,0.001319918,-0.011279464,-0.034703754,-0.028800162,-0.05114942,-0.044168185,0.0043765157,0.08482463,-0.0111634405,0.042057104,-0.04534114,0.07949867,-0.036770616,0.05205938,-0.023237824,-4.139229e-08,-0.029296473,-0.016308213,0.01927843,-0.036230844,0.023393711,-0.021085573,0.051369485,-0.0019050121,0.098878495,-0.02178415,0.001747992,0.08526182,0.025981853,-0.020373456,-0.036635086,-0.014597301,-0.0012716342,0.062953345,0.018635971,-0.009851777,0.0058950847,-0.004587809,-0.078390196,0.01480106,0.019273957,-0.05559297,-0.017057782,-0.0049056793,0.03147964,-0.05752116,0.025736824,0.0044927495,0.027153946,-0.07456512,0.041085657,0.07117877,-0.060109984,0.047391616,0.018014101,0.005332745,-0.052492388,-0.11170973,-0.013995774,0.038919784,0.0174326,0.006850687,0.028237768,0.030708343,-0.0018760416,-0.0023768174,-0.061286528,-0.00029825122,0.018025883,-0.108084686,-0.07919035,0.022145608,-0.014064895,-0.08379762,0.0059287073,-0.05989282,-0.0005105856,-0.008089655,0.1642266,0.015485418 +1.14.14.17,"A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7, lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase [5,7].",384,0.99999994,-0.08328395,-0.06173556,-0.09900173,0.01631521,0.10149322,0.0046369275,-0.06020128,0.07595469,0.047053616,-0.0457991,0.0012309724,0.007880553,-0.07398428,0.007191525,-0.10235196,0.026278919,-0.07730084,-0.013304854,-0.022986962,-0.022711432,-0.0016369544,0.011192805,0.062612064,-0.039111856,0.05446016,-0.018854093,0.039825022,-0.05200162,-0.050105628,-0.043620642,0.090009235,0.02783888,0.04188776,-0.013823766,-0.05782254,0.054183453,0.036955744,-0.03481406,-0.012135604,0.04299141,0.03456171,-0.042957608,0.028869314,-0.038903642,0.05486739,-0.0029101823,-0.011292336,0.04779692,0.008616623,0.029374018,-0.009902087,-0.054474324,-0.09129107,0.025733352,-0.0073546376,0.037648626,0.021259453,-0.07332023,0.01677937,0.006921104,0.029579211,0.0059056757,0.042989463,-0.011492354,0.033338193,-0.033777524,-0.020958463,-0.07471942,0.01962439,-0.05039138,-0.030000923,-0.044630907,-0.04882505,0.052640907,0.01316494,0.051390503,-0.093389615,-0.048007715,0.050642014,0.005228115,0.055632472,-0.038696986,0.025676737,0.053803504,0.108291686,-0.009775885,0.030412387,0.0065396186,-0.05913331,0.022892144,-0.02298884,-0.00812059,-0.015709803,0.02986551,-0.107335635,0.07118051,0.04384164,0.030461662,-0.06922046,-0.030557385,-0.020403508,0.026726892,0.008228156,-0.05845816,-0.08146443,-0.08022169,0.014592006,0.08862319,-0.02160471,-0.06599017,-0.030242352,-0.033992358,0.0025288241,-0.039149407,0.009463772,0.06838149,-0.05624987,-0.071128644,-0.026161252,0.033475194,-0.018590637,0.09466671,0.03021574,0.13185443,0.0684313,0.003973856,-0.13319649,1.6918578e-33,0.07890893,0.059612304,-0.0021822727,-0.009539094,-0.014529946,0.011359285,-0.08287236,0.011530712,1.0510035e-05,-0.06783306,-0.009756178,-0.011732971,0.04542964,-0.07330626,0.03680791,-0.029725932,-0.011854597,-0.017372886,0.103820175,-0.12347245,0.016175793,0.0516312,-0.036450744,0.072656885,0.040256523,-0.0043034023,-0.068838015,0.045703158,0.07007684,0.039468262,-0.016580911,-0.03894914,-0.048536103,-0.011676016,-0.03749528,0.022857487,-0.08279144,-0.10168271,-0.080068976,0.06849272,-0.006176553,-0.023553567,-0.015257486,0.0073975087,0.039553072,-0.04553705,-0.07831471,0.076881565,0.024923773,0.06788418,-0.035777897,-0.044404957,0.13004223,0.044593386,-0.04515018,0.003834908,-0.07729452,0.009127162,0.013390132,0.023796309,0.048270468,0.110555924,-0.040622447,0.08635701,-0.10948974,0.009605582,0.033451915,-0.10393669,-0.021603057,0.08943359,0.01607522,-0.004359216,0.07932323,0.009131792,0.087977,-0.045864075,-0.025923384,-0.04111012,-0.010607638,-0.021084582,-0.027679168,-0.029826382,-0.038123123,-0.041524358,-0.024345433,-0.001088098,-0.050170884,-0.026974898,0.010008546,0.024891462,0.055246837,-0.08877883,-0.026874946,0.00015478088,0.023590242,-6.1673014e-34,0.030988546,-0.08659442,0.053792052,0.0012722044,0.03432326,0.043742888,0.04903116,-0.03448123,0.030839134,-0.04744836,0.07228137,-0.07550985,0.011053535,-0.049542554,0.053101443,0.014196419,-0.017037911,-0.053903606,0.08670311,0.04156101,-0.016176341,0.0016184011,0.05439968,0.07080128,0.05591937,0.0228311,0.012718181,-0.02472794,0.04175983,0.026381778,-0.06537318,0.05460732,-0.058267903,-0.0051825647,-0.08626796,0.049875613,-0.004074492,0.008642308,-0.019582503,0.031664558,-0.035937004,0.023477586,0.0063718893,0.07540398,0.07822808,0.040086146,-0.012593868,0.07041826,0.088676244,-0.074044555,0.01646273,0.06419775,0.025114134,0.03705132,0.0543386,0.04632422,0.041787922,0.081239,0.0113390945,-0.023355437,-0.0111423135,-0.09647557,0.020953048,0.00247972,0.072490685,0.051334955,0.02869056,0.123801686,-0.02831073,0.033229534,0.13692333,0.0044115544,0.011219468,0.07607053,-0.0016393884,-0.06263188,-0.005809516,0.067817345,-0.0020728435,-0.009124899,0.03283419,0.014323814,0.008020709,-0.013137391,-0.055393398,-0.0964048,0.037878573,0.09174088,0.0005021217,0.033840533,-0.052739635,0.03139126,-0.058428243,-0.011756814,0.07499686,-3.400783e-08,0.022919241,-0.040947784,0.010661763,-0.040326037,0.13601908,-0.0033198188,-0.010477647,-0.014888122,0.009511895,-0.015880756,-0.06282038,0.1308667,0.041766513,-0.027173478,0.055121377,-0.03854372,-0.004330718,0.040931422,0.00080561114,0.01794114,-0.0031052546,0.036620826,-0.11945056,0.004403617,-0.061508153,-0.016393917,0.009491278,-0.01415045,0.012443545,-0.04681618,0.0035634134,0.02328128,0.034570877,-0.015065348,-0.10843225,0.017846186,-0.0070468606,-0.031235002,-0.05698912,0.06358016,-0.07030098,-0.02797543,-0.009524734,-0.027647467,0.0061671142,-0.0015165915,0.06215177,-0.07027302,0.0033752094,-0.031523596,0.0010058001,-0.0419825,0.019671336,-0.03065355,-0.053716525,0.014953115,-0.02643152,-0.096142925,-0.017374268,-0.06495626,0.008591272,0.020631034,0.13204698,0.048341386 +1.14.14.18,"This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The enzyme requires NAD(P)H and EC 1.6.2.4, NADPH---hemoprotein reductase. cf. EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin).",384,1.0,-0.015003371,0.007151559,-0.089694604,-0.002541469,0.06852948,0.017827539,0.00087393826,0.06835114,0.09256068,-0.026064515,-0.04252999,0.018657371,-0.121004045,0.01320555,-0.040132646,0.05980049,-0.11294945,0.040171035,-0.025355276,-0.08060339,-0.011272045,0.038765553,-0.007879956,0.043754477,0.005892367,-0.04786493,0.067671195,0.003589461,-0.02157515,-0.04789416,0.001902341,-0.04946538,0.05224009,-0.039239906,0.006984916,0.046789106,-0.011498293,-0.041589785,-0.021736031,0.046167742,0.05070827,-0.01031737,-0.08499468,-0.009786208,-0.038225375,-0.00043034513,-0.0034369554,0.00055474613,0.011702201,0.064706124,-0.044141244,-0.0062815133,-0.083430275,0.0077489642,0.028219635,0.027530922,0.0006736263,-0.0104187215,0.058049876,-0.041383404,-0.0085710455,-0.029126616,-0.0135826245,0.010535046,-0.009648318,-0.09291574,0.09013157,-0.064307414,-0.065153666,-0.071906015,-0.05390229,-0.032431025,-0.080503434,-0.038218528,-0.04534302,0.076451704,-0.029385561,-0.06917729,0.046661675,0.003784565,0.03897947,0.018132847,0.029430773,0.110091835,0.05056631,0.06366972,-0.06291053,-0.034317125,-0.08360907,0.0040288405,-0.030313259,0.04482363,-0.012600066,-0.0018823377,-0.042492837,0.055681575,0.11443475,0.061698504,0.017894149,-0.014711994,-0.030570915,0.069650255,-0.051948268,-0.1075568,-0.0953165,0.00862864,0.046084255,0.09046578,0.11072609,0.0029363146,-0.016442267,-0.02888018,0.06736788,-0.034155816,-0.009204185,0.15567374,0.009793517,0.032446194,-0.05619522,0.07178015,-0.019094696,0.07235026,0.05331537,0.015413582,-0.008995159,-0.03757975,-0.024937076,1.8123388e-33,0.09672245,0.043296598,-0.007809479,0.0651593,-0.053927265,-0.0117808,-0.1349348,-0.04083842,-0.04723698,-0.07489164,-0.00016828824,-0.10015884,0.04534765,-0.06917149,-0.014318679,-0.049389467,0.0013292134,-0.03884601,0.029212944,0.0037368736,0.036567856,0.07482605,-0.014133071,0.066972785,0.05268332,-0.004148437,0.001411357,0.06272018,-0.0033013585,-0.018274946,0.017158857,-0.019590585,-0.13630514,-0.040607937,0.006653373,-0.078779966,-0.04092943,-0.0018223297,-0.07479239,0.05857409,-0.014641896,0.012413188,-0.033838674,-0.0819782,0.11065966,-0.12177478,-0.03075405,0.08659256,0.056073677,0.12677099,-0.026268251,-0.020549186,0.12449025,0.012777193,-0.06753972,-0.01972301,-0.023638533,-0.04560244,0.047845356,0.06998018,0.09759699,0.08514978,-0.0032601126,0.03213182,0.038577564,0.034850806,-0.05452869,-0.07860734,0.022888636,0.0113908155,0.0150276385,0.0151825445,0.017120402,-0.025468947,0.009792478,-0.040996067,-0.106096275,0.04476096,0.025515711,-0.05593868,0.029251391,-0.012321309,0.04969109,-0.0046863486,-0.013002811,-0.030434657,0.0028013228,-0.03975084,-0.03602374,0.007621477,0.056803398,-0.11356352,-0.0758674,-0.077863425,0.06323173,-1.2228622e-33,0.0960967,-0.0144889755,0.017274333,-0.072509676,-0.03192157,0.062407177,0.013984179,-0.070094466,-0.05026711,-0.045931,0.056053612,0.030434098,-0.009722117,-0.018983714,0.024815666,-0.012683399,-0.005097788,0.010611841,0.015142948,-0.03490747,-0.0077891396,0.035973553,0.0039434195,0.031603597,0.0400868,0.00960067,-0.04492586,0.0017985125,0.11348532,0.005124965,0.002727423,0.035127584,-0.0520292,0.021595001,-0.025675952,0.04369485,0.0009821769,0.08309008,0.0144523475,-0.026334938,-0.0032563931,-0.029786447,0.042176165,0.011538806,0.061863877,0.05631892,-0.04036186,0.021425491,-0.031150118,-0.0006842133,0.009343032,0.060112696,-0.04802965,-0.020319587,0.04041735,-0.007461489,0.063386455,0.029209806,0.007577719,-0.033262014,-0.020502705,0.009674485,0.070762455,0.093965404,0.011667615,0.054785173,-0.02472401,0.06696792,0.07200873,-0.03434247,0.0795429,0.055090748,0.061368186,0.023728149,-0.00070633355,-0.01531552,0.048312537,0.026256347,0.010378871,-0.0047963643,-0.05053345,-0.03143698,0.0005786073,-0.06899449,-0.007599303,-0.10933107,-0.0016782999,0.034330063,-0.0152399205,-0.04656848,-0.031914428,-0.039200455,-0.059012372,0.009240967,0.04324662,-4.026816e-08,-0.008532208,-0.051857956,0.01363312,-0.020716768,0.013527775,0.011972311,0.09333613,0.043798257,0.03431265,0.041486844,-0.005809872,0.067359455,0.052063167,-0.026215572,0.081357375,0.04931868,-0.013337082,0.01986834,0.025527587,-0.05172889,-0.03908176,-0.03797125,-0.09986466,0.084530324,-0.012547214,-0.11134071,-0.03215092,0.0060829185,0.030974649,-0.024693755,0.06150786,0.033839107,0.091216885,-0.047591653,-0.0004838883,-0.037686057,-0.04913034,0.04384219,-0.029177193,0.03244603,-0.03422421,0.00024949576,-0.06747506,-0.05146445,0.04043072,0.02039833,0.048348974,0.022327475,-0.011708035,-0.040037777,0.04460936,-0.016548002,0.016176375,-0.023193415,-0.094966225,0.05367604,0.029824378,-0.024924548,0.056669153,-0.09207373,-0.03343646,0.0040438925,0.14968324,-0.038744178 +1.14.14.19,"Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17alpha-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17alpha-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 1.14.14.32, 17alpha-hydroxyprogesterone deacetylase). The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones.",384,0.99999994,-0.022934763,0.01057703,-0.06968035,-0.07963852,0.037780985,0.028541084,-0.08620821,-0.0029977723,-0.019320367,0.026653485,0.00022020243,0.03966061,-0.07488324,-0.015267544,0.049289588,0.055777084,-0.027886705,0.0021074782,-0.010428292,-0.043019608,0.053400513,-0.024096886,-0.07058532,-0.044530097,0.08994674,-0.091917336,0.014238054,0.028825881,-0.1033049,0.0063729244,0.012776815,0.0152930645,0.023231748,-0.08460241,-0.035365988,0.0398863,-0.09393725,-0.11477097,0.06661043,0.06078414,0.012487875,-0.05112871,-0.07586233,0.019971002,-0.052091345,-0.032078963,-0.029421961,0.08657166,-0.035055686,0.028351005,-0.0062043257,-0.016974162,-0.030799199,0.07460694,-0.00093577185,-0.042977426,-0.040358484,-0.017027665,-0.020450987,-0.019405501,-0.0802617,-0.032404073,-0.07810322,-0.027085187,-0.02650185,-0.046024397,0.08610786,-0.05674096,-0.02474522,-0.025905568,0.021848049,0.0006073181,-0.032918297,0.027131211,-0.033917405,0.05017116,-0.05132173,-0.021441339,0.025397897,-0.021874001,0.023167998,0.019088449,0.012836248,0.15112822,0.055160787,-0.021019053,-0.035802424,0.04834657,-0.025653856,0.106772274,0.011427337,-0.05389311,0.0027066977,0.048614375,-0.020674175,0.05049398,0.022304999,-0.04059741,0.0017257009,-0.036077026,-0.023873769,0.07343326,0.030982992,-0.0327855,-0.07674589,0.040495012,0.026155965,0.087451085,-0.009841622,0.009932077,0.02821849,-0.025750317,0.031618915,0.032871604,-0.00052460976,0.068403095,0.06793799,0.008024059,-0.07249857,-0.0845193,0.032867175,0.018228363,0.07659449,0.049756072,-0.024064284,-0.03318451,-0.079340406,4.8919608e-33,0.10728172,0.0026383165,0.02990334,0.046282444,-0.041509572,0.14413607,-0.06275957,0.037446387,0.02957057,-0.07139999,-0.03934776,-0.055256125,0.034858737,-0.06568501,-0.007524478,-0.04419376,0.048593692,-0.045029677,0.07575156,0.027938507,-0.016725188,0.07937484,-0.114533976,-0.034002405,-0.002591059,0.04126638,-0.055663735,0.055759642,-0.057477184,0.016819535,-0.059214994,-0.0770055,-0.00792095,0.005837999,0.040717836,-0.05638036,-0.05430591,-0.06379502,0.034356087,0.015213413,0.006353953,0.023418335,-0.0015508622,-0.080346026,0.05082221,-0.011505043,-0.017842034,0.0039851656,0.05584089,0.07344682,-0.0008749553,0.04816428,0.08249497,-0.004543222,-0.06713226,0.09045998,-0.05230177,-0.04666628,0.015564095,0.107789256,0.0142379105,0.049682766,0.035747882,0.006861073,-0.048473123,0.0065485425,-0.027858157,-0.114316724,-0.06262218,0.081183955,-0.0095346235,-0.0017783506,0.1001923,-0.012340382,0.05154392,0.028498093,0.049732927,0.04697991,-0.0042018197,-0.0578589,0.0059697363,0.056576673,-0.05085702,-0.0032507223,-0.0113706775,0.04786554,0.0064301374,-0.04049587,0.02910946,0.085520476,0.05090759,-0.096674845,-0.004847214,-0.02400791,0.062070888,-5.9559393e-33,0.097681925,-0.13501827,0.023987738,-0.12996055,0.017959056,0.0808998,0.114716895,-0.08132979,-0.00060935604,-0.021227937,0.037151024,-0.034328908,-0.084697545,-0.05617667,0.061360482,0.015184812,-0.059277806,0.07906371,-0.049113117,-0.020424996,0.0129358955,0.103466764,0.038318284,0.08656516,0.06528629,-0.06298095,0.018037554,-0.036027987,0.050141767,0.096480876,-0.042702753,-0.030676223,-0.059408925,-0.028257348,0.016934648,0.07713011,-0.09487484,0.08087133,0.04178984,0.009444678,-0.031666454,-0.012601555,0.017427135,-0.033121396,0.028064547,0.037703373,-0.04747564,0.03774736,0.018172631,0.013050555,0.004024201,0.007442136,-0.0997686,-0.015842613,0.002210003,0.01488974,0.042824533,0.017020402,0.04685369,-0.024190282,0.0013915742,-0.051757965,-0.06094475,-0.010639302,-0.020925237,0.007944784,0.029969105,0.017398966,0.059495885,0.039964452,0.041173164,-0.017345225,0.06352487,0.06715829,0.026179226,-0.111662626,-0.036576726,-0.07495503,-0.004609592,0.011820328,0.036289796,0.009985005,-0.04046544,-0.01566198,-0.07708108,-0.05841051,0.014435467,0.04902105,-0.06046501,0.0339709,-0.038386185,0.006613513,-0.087195955,0.028518748,0.0115207825,-4.517943e-08,0.014210448,-0.04457726,-0.007274106,-0.016057229,-0.036829937,-0.025167637,0.011306912,0.0014280712,0.091987826,-0.030075865,0.050334938,0.11167664,0.023244053,0.009942266,-0.008725024,-0.0375081,-0.019418413,0.037048567,-0.016420897,-0.028817229,0.026482197,0.009875171,-0.13103724,0.041750696,-0.034617122,-0.040199902,-0.004553303,0.02841199,0.088517904,-0.04924423,0.076470144,-0.051069297,0.05367274,-0.03708336,-0.0024563363,0.028004056,-0.035400737,0.013036329,0.0916148,0.016826175,-0.045216158,-0.08983325,-0.0060185567,0.07344981,0.0152817685,5.783091e-05,0.023125986,0.027289584,-0.021254763,0.03750322,0.0148777515,0.010647554,0.055841904,-0.046637416,-0.013889478,0.005096703,-0.019371988,-0.08653372,0.0052609453,-0.0384281,0.018780723,0.012715084,0.124481924,-0.037923817 +1.14.15.14,"The enzyme, found in pathogenic and nonpathogenic mycobacteria species, actinomycetes, and some proteobacteria, hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. It is a P-450 heme-thiolate enzyme.",384,1.0,-0.05079387,-0.004877957,-0.105470054,-0.01189923,0.018861732,0.040697493,-0.039834492,0.13731532,0.014553803,0.024592191,-0.016755544,-0.07341655,-0.035784636,0.040511306,-0.0065898877,0.06593618,-0.024565553,-0.0017619334,0.011377168,0.029552609,0.055135448,0.11431794,0.00054007565,-0.00090758613,-0.028484674,0.0024647727,0.07595823,-0.00023697925,-0.016210502,-0.05520043,0.007253005,-0.051199347,0.054227248,-0.024710909,0.08613403,0.08362885,-0.00801458,-0.08077672,0.07537109,0.02643704,0.097928464,0.011650852,0.021108158,0.01765429,0.02678043,-0.012727217,-0.05958661,0.08772262,0.021572616,0.0030605998,-0.07371329,-0.120627455,-0.045495044,0.022785898,-0.030607922,0.014666517,0.05274078,-0.091065705,0.056860887,0.08929606,0.0878036,-0.0333664,0.036038056,0.015932256,-0.028403876,-0.057554048,-0.014529755,-0.045954414,0.011885189,-0.07384487,-0.107003644,-0.05032435,-0.07439427,0.11282092,-0.023206336,-0.05539871,-0.0071679708,-0.03288626,0.04255028,-0.017532455,-0.041067757,-0.06425504,-0.019233936,0.039524134,0.061954163,-0.018488903,0.03449717,0.052565854,0.03498744,0.065844946,-0.018538099,-0.030147739,0.026941393,-0.030129716,-0.10566086,-0.013224785,0.08687532,0.005927337,0.037526507,-0.038677182,0.055811543,-0.049285915,-0.0061034923,-0.09084856,-0.03244102,0.011202427,0.0002696631,0.050669968,0.032765646,0.0027082362,-0.066084534,0.06869949,-0.0031028197,-0.0209679,0.014961669,0.06420306,0.12710395,-0.03925597,-0.094273925,0.0068737273,-0.03863874,-0.06944062,0.07441721,-0.028698932,-0.081570484,0.008612398,-0.049420856,2.6194121e-33,0.04847815,-0.03207249,0.024326047,-0.033008248,0.04549443,0.0034860286,-0.09969936,-0.004345089,-0.023848308,-0.023986096,-0.079379395,-0.10118531,0.003375056,0.04300716,-0.04660884,0.033113997,-0.04618521,0.031230953,0.062154405,0.006773056,-0.03467373,-0.008839441,0.026115932,0.01884452,0.03018085,0.07794562,-0.012308972,-0.004467467,0.08746607,-0.011592502,0.029248608,-0.11732106,-0.068560146,-0.06081154,0.040736105,-0.01227923,-0.07760112,-0.035891924,-0.004084608,-0.002416893,0.02443883,-0.024490153,0.011183908,-0.013799929,0.03994939,-0.037496846,-0.051255804,0.04058349,0.05123551,0.014659607,0.02529471,-0.037286878,0.030069526,0.0026870612,-0.051562026,-0.047477826,-0.009141981,0.10323608,0.0090816105,0.02862843,0.098498724,0.07264862,-0.029303933,0.114450715,-0.039401956,-0.015950132,-0.05345135,0.0075530796,0.03453038,0.04553022,0.016116107,0.0033631045,0.06724999,-0.024404,0.031432353,-0.0672021,-0.048518784,-0.00849034,0.009734506,-0.017735502,0.024884328,0.012259361,0.00829725,-0.006168062,-0.045572612,0.00025945445,-0.040719192,-0.048832275,-0.013511337,0.01926325,0.012570492,-0.058714204,-0.08177773,0.030891346,-0.039128475,-4.063204e-33,0.058873408,-0.0987581,0.104585804,-0.09606012,0.021320907,-0.0055712285,0.035213515,0.012975669,0.023462165,-0.04650168,0.126815,-0.010151491,0.01761296,-0.021246877,0.04751466,0.049159233,-0.022031209,0.032983374,-0.013248391,-0.074856885,0.010207047,0.008489485,0.024130816,0.0067174174,-0.0034361777,0.023617452,-0.029013518,0.00497077,0.06836039,0.08985215,0.011958728,0.049936593,-0.0311539,-0.09640905,-0.070235305,-0.025157753,-0.06280401,0.029974148,0.04355046,-0.013149014,-0.0465412,0.026753878,-0.0140266605,0.036268484,-0.03562436,0.09953185,-0.07027479,-0.07034259,-0.017050976,-0.021457156,-0.027671896,0.0021192208,0.039282486,0.05338305,0.008651499,0.020029785,-0.011922299,0.0014107424,-0.0048092003,-0.10776519,-0.06955644,-0.039936956,-0.01219113,-0.021068068,0.064862825,0.097943805,-0.010314668,0.04888236,0.04858606,-0.04137858,0.060054787,0.0687565,-0.065706484,0.02311126,-0.068441994,-0.014809786,0.008370445,-0.011421868,-0.02032721,0.022247054,0.041763913,0.012189095,-0.024047468,-0.10300995,-0.040618457,-0.11563169,0.041736223,0.10274026,-0.023706442,0.08171141,-0.028753133,0.0823683,-0.09989197,-0.012502357,0.073432565,-4.402127e-08,0.0055226255,-0.10343881,0.03935908,-0.037937656,0.022567539,0.039240833,-0.03184805,0.041463424,0.065185875,-0.0036986426,0.020074243,0.079146214,0.036151525,-0.0436715,0.023515357,-0.0075193425,-0.08395934,-0.00980378,0.029696548,-0.006151567,-0.04149768,0.021814687,-0.014616448,0.02492438,0.013215858,-0.038085718,-0.0030865774,0.043870326,0.019603556,-0.006557797,0.029518263,0.075409986,-0.01894776,-0.015026666,-0.07455248,0.034947492,-0.06629104,-0.04285757,-0.05972421,0.0873075,0.06296558,-0.028012859,-0.09545235,0.030869827,-0.0077815773,0.034695864,-0.046729892,0.07467486,0.016505804,-0.02039355,-0.0033552689,0.014765011,-0.03975042,-0.013346758,-0.071917854,0.09035327,-0.010282847,-0.040781796,-0.08732918,-0.03462196,0.04257739,-0.018589044,0.17646833,-0.025710663 +1.14.18.8,"A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH---hemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid [2].",384,0.99999994,-0.040188868,-0.04968538,-0.040777985,-0.054171827,0.029461876,0.05917728,-0.06498226,0.122108534,-0.01717332,-0.043995056,-0.036586706,-0.00688791,-0.086089514,0.0055822963,-0.017391708,0.05654251,-0.047174208,-0.0047659744,-0.028851265,-0.13036193,-0.029646918,-0.010315706,0.038266778,0.008872618,-0.037277196,-0.028373078,0.109272696,0.029315285,-0.064253256,-0.058475405,-0.064510055,-0.036113072,0.0832999,-0.03891942,-0.051590797,0.11430797,-0.069695525,-0.034913983,-0.0063178814,-0.01404666,0.081398465,-0.03745105,-0.08990096,0.011604519,-0.0026883758,-0.043794025,0.002733493,0.04551291,-0.0015649716,0.026788749,-0.041276984,0.027102903,-0.02370538,-0.00414749,-0.020358518,0.020535294,0.042458758,-0.028344495,0.030123422,-0.09347331,-0.03414226,0.0068912217,0.039399408,-0.04872104,0.0061598904,-0.034909282,0.06190044,-0.053860117,-0.009640858,-0.06004716,-0.049105257,-0.060487006,-0.07445921,0.06880484,-0.07185058,0.079414465,-0.061082568,-0.034517355,0.020224972,0.0011421436,-0.01565926,-0.006922233,-0.02637953,0.104413375,0.09431717,0.0053088707,-0.060971644,0.043109056,-0.080002725,-0.03543579,-0.00013893255,0.008983155,-0.02066981,-0.0045671514,-0.0731986,0.023902247,0.01973626,-0.004906718,-0.016483292,-0.049656156,0.06715631,0.090929694,-0.019720497,-0.061898045,-0.049377933,-0.024724582,0.015693853,0.081715204,0.059333824,-0.07443993,0.024832139,-0.058995727,0.049534954,-0.0628382,-0.0010396716,0.16822433,-0.0737989,-0.02731063,-0.024081064,0.037555333,-0.025264349,0.039041884,-0.0025812606,0.039061304,-0.042473026,-0.05880926,-0.056978572,3.02739e-33,0.09571997,0.013891065,0.006830538,0.03408034,0.0041570477,0.02212321,-0.086050875,0.01206225,0.0028266248,-0.043752257,0.039513633,-0.08535588,0.036049895,-0.06859305,-0.027161859,0.016116224,-0.02594241,0.027141906,0.027430968,0.014598757,-0.061910152,-0.006832145,-0.0491773,0.010148019,0.06390351,0.06996722,-0.0024662975,0.0057103634,0.009279342,0.027331067,-0.04368404,-0.0568933,-0.027052725,-0.04946347,-0.0055954787,-0.0030840645,-0.05227225,0.038287,-0.06716799,0.06416784,0.038771383,0.0065840157,0.0041430565,-0.050700303,0.05907654,-0.05586737,-0.058162298,0.060059868,0.013173204,0.056799673,0.03731127,-0.055232026,0.13346274,0.038184606,0.0020560974,-0.062822,-0.016572796,0.031361196,-0.0069017215,0.06757884,0.16470769,0.081102915,-0.07668481,0.07527754,-0.031463187,0.04301932,-0.065228894,-0.052036352,-0.03486504,0.081416495,0.014678956,0.0060954597,0.053698663,-0.0042104525,-0.03138941,-0.014763317,-0.012030942,0.09356431,0.019258253,-0.00040482334,-0.014773525,-0.0034407985,-0.029077958,-0.026257273,-0.024010824,0.012750879,0.056380823,-0.008193593,-0.055698458,0.028645173,0.051758524,-0.050113827,-0.01599543,0.032830913,0.013541275,-3.0715061e-33,0.037528872,-0.0682162,0.014679788,-0.05786579,-0.034711383,0.0848568,0.0510558,-0.07345994,-0.010802579,-0.040803414,0.09540573,-0.0278594,0.010478953,-0.010488721,0.05613126,0.017115002,-0.029327048,0.017551795,0.0028017897,0.052020635,-0.008143844,0.06480174,0.05153318,0.06545325,0.03500698,0.055589646,-0.03457253,-0.024841107,0.058862265,0.010891292,-0.054394294,0.05285267,-0.096471,-0.038064383,-0.068305045,0.005389463,-0.0015981214,0.0343675,0.032461643,0.04396013,-0.043800756,0.08690514,0.015251122,0.033894897,0.0027205206,0.10063332,0.0144952405,-0.038655754,0.028919654,-0.048394136,0.05292394,0.00020583856,-0.041698642,0.05224703,-0.017781697,0.06109872,-0.049583644,0.065958016,0.0001496544,-0.1433027,-0.10827393,0.019338638,0.035936818,0.04913303,-0.017711047,0.07323649,-0.04504995,0.06770181,0.02572098,-0.034625027,-0.0079746535,0.029637704,0.10387988,0.10575752,0.0007145657,0.020804478,0.0026588072,0.013172951,0.069688186,-0.012190504,-0.051763006,0.016449668,-0.068907835,-0.055048622,-0.017639384,-0.07731408,-0.083399534,0.07717968,0.05921086,0.005826048,-0.033878017,0.013336428,-0.08916232,0.03970636,0.024400445,-3.972808e-08,0.040492535,-0.078170925,-0.029723758,0.030763486,0.05099979,-0.004846095,0.042762082,-0.0033401987,0.06209242,0.007992335,0.009929667,0.084079176,-0.003839604,-0.017303888,0.011606374,0.03620209,-0.006113372,0.037317067,0.03595544,-0.026202269,-0.062152047,-0.013752081,-0.022787832,0.029578991,0.029347545,-0.05388227,-0.0138838,-0.0666166,0.04782942,-0.0352366,0.02824027,0.022777282,-0.032656584,-0.016173111,0.07354426,0.015037449,-0.067375965,0.030200867,-0.017639404,0.06247845,-0.010190128,-0.07977471,-0.079315186,-0.009804582,0.047530565,-0.030310128,0.020117024,0.037447028,-0.033036694,-0.030436529,-0.090291224,-0.013026609,0.061325215,-0.06925235,-0.07613043,0.05791381,0.08064692,-0.073116116,-0.058718447,-0.08418093,0.031777274,0.034281567,0.15832305,-0.042717915 +1.14.19.37,"The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC 1.14.19.44, acyl-CoA (8-3)-desaturase.",384,0.99999994,-0.10654348,-0.07120607,-0.08336443,0.023036638,-0.0024594697,0.049888704,-0.12798978,0.023120485,0.052478623,-0.019396981,0.12413292,-0.0747296,-0.11800309,-0.02099425,0.03870275,0.0035596795,-0.024443302,0.012808459,-0.06525564,-0.088758364,0.10206441,0.053511098,-0.047022328,0.029489508,0.0225891,-0.05054782,-0.007577732,-0.070513144,-0.022075655,-0.10027226,0.012718906,-0.04172601,0.0061472505,0.068115294,0.02306521,0.07580181,0.01967481,-0.11209137,0.06483153,0.0043552923,0.05935054,-0.096877426,-0.03036928,-0.022940688,-0.05205998,-0.07862232,-0.03153994,0.023502406,0.054180577,-0.06973357,-0.046337306,-0.05576581,-0.05758539,-0.030756718,-0.04906375,0.033400822,0.045803756,-0.01744905,-0.052834734,0.051803514,0.075745344,0.011123366,-0.016048297,0.059750754,-0.044505946,-0.03582813,0.046437215,-0.053214632,0.057161488,-0.01097443,-0.033846423,-0.0932048,-0.015970338,0.010668791,0.000330475,0.053648144,-0.03040158,-0.04402406,-4.3974604e-05,-0.006576625,-0.017807718,0.023543188,0.057171047,0.07220084,0.01721357,-0.021811143,-0.015937021,0.048997648,0.016992712,0.018114401,0.04899935,0.032023933,-0.020941913,0.036935292,-0.11254877,0.10652734,0.070826985,-0.059063222,-0.046570756,0.0010690618,0.032735687,0.08056992,-0.099327736,-0.07024172,-0.05404538,-0.006116083,-0.032661278,-0.022084553,-0.030749299,0.0019979451,0.020988114,0.0042366902,0.014126482,0.057308454,-0.020584144,0.015129374,-0.00690757,-0.03180844,0.0141624315,-0.009384943,-0.048454765,-0.054324538,0.007591551,0.043924578,-0.020248218,-0.010430493,-0.12792142,1.7770707e-33,0.04503177,0.031752553,0.003030523,-0.04116853,-0.020759512,-0.07944929,-0.09937825,0.07670086,-0.10916794,0.016053729,-0.0059987386,-0.05481044,0.01942636,0.058449194,-0.02964279,0.004069513,0.020754827,0.04086546,0.06936521,0.004421776,-0.064456865,0.04834041,0.010313916,-0.022141103,0.010147188,0.03782113,-0.053793613,0.0013528104,0.0868802,0.013258563,-0.048202682,-0.08491295,-0.034849018,0.06328435,0.13444091,0.013977417,-0.042278625,0.0014519468,-0.07604732,0.068882644,0.07597405,0.06543598,0.030886568,-0.047838286,0.078709975,-0.016443413,-0.03485683,0.048694786,0.035367336,0.05197839,0.03920934,0.062440883,0.058646053,0.00087126385,-0.07769392,0.053375255,-0.004035952,0.057759404,-0.03699443,-0.0029487559,-0.058809154,0.032354485,-0.05129122,-0.03956442,-0.02277591,0.045668866,-0.12569888,-0.04237559,-0.0022395416,0.06886612,-0.012023134,-0.041984096,0.036073808,0.0717165,0.047634333,-0.03403748,-0.050410964,0.026333658,0.019565701,0.058622975,0.009678155,-0.009454787,0.04388477,-0.023887768,-0.07023672,-0.0040328144,0.0023307204,0.032579694,0.041885722,-0.004494895,0.056900844,-0.012855618,0.00838051,-0.05238505,0.100302175,-3.6131985e-33,0.085253336,-0.06967449,-0.0115926415,-0.111578,-0.01223282,0.02974633,-0.024402844,-0.067769445,0.028582763,-0.013027873,0.12642321,0.032149598,0.016151873,-0.07015905,-0.00013558882,0.035265535,0.022351807,0.09968198,0.0032793598,0.025156327,0.0014954514,0.045772363,0.07110469,0.07239676,0.08372222,-0.017095374,-9.018648e-05,0.09075073,0.0049897777,-0.023053395,0.07664262,0.0003633432,-0.029768495,-0.046066932,-0.039954223,-0.024305202,-0.09977326,-0.009021375,-0.005369044,0.064624265,-0.0077824346,0.031552587,0.02652409,0.03172715,0.058759816,-0.009807877,-0.0709495,-0.030113922,-0.042972326,-0.051204823,0.016429503,-0.014277693,-0.012568477,0.009760852,0.074414104,0.04157099,0.015041443,0.05031735,0.02555045,-0.062697895,-0.00047394328,-0.02858866,-0.02977429,-0.04651048,0.070916235,0.03786308,-0.022956308,-0.022429444,-0.015493447,0.036613543,0.0913953,0.09199587,-0.05482866,-0.004076844,-0.04940775,-0.06760651,-0.046797104,-0.07159413,-0.06700283,-0.01651609,-0.041543633,0.012780022,-0.03601572,-0.071738616,-0.02199923,-0.04907062,0.021306738,0.086811036,-0.010316371,0.06959619,-0.0016866403,0.0009724289,-0.020468423,0.08126463,0.07662936,-4.2168598e-08,0.01611859,-0.057071533,-0.02567904,-0.050997674,-0.0060321596,0.0011723244,0.0044776374,-0.074562676,0.05702968,-0.025078032,-0.043838963,0.029499691,0.061451275,0.07845069,0.00984341,-0.01967926,0.037224684,0.036717467,-0.027175939,0.007981425,-0.022947878,0.0106179,-0.08683784,0.03614202,0.017501388,-0.0061152973,0.030415548,0.011372226,0.049962297,0.051417444,0.010752804,0.009234682,0.041427024,-0.027693897,0.019769596,0.01372884,0.060815647,-0.04786514,-0.056468133,0.081202604,0.06471644,0.0026288626,-0.06387166,0.050497003,0.050120506,-0.015110498,0.024172202,0.057728473,0.0003975567,0.03783859,0.022360483,0.013576348,-0.055683427,-0.035065252,-0.09430024,-0.05332754,-0.010734584,-0.04602544,-0.075624265,-0.0265446,0.045608245,-0.047196228,0.16165164,-0.07017919 +1.14.19.38,"The enzyme, characterized from the moss Ceratodon purpureus, converts the double bond at position 6 of gamma-linolenate and stearidonate into a triple bond. The product of the latter, dicranin, is the main fatty acid found in C. purpureus. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The enzyme also has the activity of EC 1.14.19.47, acyl-lipid (9-3)-desaturase.",384,1.0,-0.103819124,-0.0341684,-0.11077913,-0.003648565,-0.027894123,0.02140187,-0.030633222,0.049301114,-0.01828422,-0.047450807,0.0749961,-0.12330376,-0.11360598,0.020361725,-0.0049323477,-0.019046437,-0.043695156,0.0133993905,0.012841173,-0.03552306,0.119329095,0.04201417,-0.0069133453,0.013924797,0.051023766,-0.0042984155,0.0028469153,-0.082758434,-0.017784607,-0.12534852,0.050546013,-0.13341905,0.07056035,0.025017237,0.06831104,0.06781007,-0.03849048,-0.090770416,0.039793342,0.0068809534,0.034229126,0.0056653526,-0.02373662,-0.0058776443,0.011630143,-0.043786068,-0.03582597,0.07253838,0.03811172,0.0063906345,-0.004281914,-0.028527737,-0.021945246,0.044133108,-0.043168712,0.04026507,-0.01508675,0.020085271,-0.074722745,-0.0045499154,0.09972926,0.0441652,-0.012400032,0.018530013,-0.055100694,-0.037941378,0.035289902,-0.11434743,0.033306714,-0.057695143,-0.04263306,-0.06153905,0.006031411,-0.036742732,-0.01702649,0.071976334,-0.057600472,-0.053876095,-0.025584865,-0.06886143,0.049940333,0.007956155,-0.0010350831,0.10574218,0.05210578,0.028613653,-0.030858219,-0.0058993828,-0.017264616,0.035364043,0.050395127,0.027171342,-0.026710192,0.04922756,-0.12107376,0.115544856,0.03454009,0.043843076,-0.004479278,0.021721872,-0.0034317547,0.06012332,-0.03756918,-0.09675397,-0.05795376,0.019913077,0.00088898855,0.0077542276,0.008724303,-0.033897247,0.0011481252,0.009130847,0.019694943,0.080294065,0.021063771,0.065126024,0.030894402,-0.08792795,0.02459433,-0.029501865,-0.04191878,-0.055813365,0.044044856,0.031949103,-0.045718797,0.0013012285,-0.10977481,7.597757e-34,0.06509181,0.029366912,-0.020560374,-0.03609914,-0.060121875,0.0026683991,-0.11581963,0.06914816,-0.10362193,-0.01896833,-0.05012914,-0.023303613,0.044281665,0.044795997,-0.0653367,-0.0423826,0.05298548,0.123361655,0.095455095,-0.022498999,-0.015827471,0.104742505,-0.044403024,-0.04635422,0.042166803,0.04587713,-0.045960404,0.01370406,0.03185653,0.014224684,0.0149845695,-0.05690119,-0.024655383,0.037442707,0.12425162,0.02980142,0.009528814,-0.0011121855,-0.07296383,0.042857233,0.06711273,-0.010362216,0.03097204,-0.019611223,0.049467463,-0.04003658,-0.054279815,0.040757023,0.04800118,-0.016675893,0.039935414,0.020564154,0.06464951,-0.0016406889,-0.04445772,0.06023317,0.016485253,0.0139490925,0.022953365,0.001215845,-0.027545556,0.072603,-0.089330725,-0.029336603,0.00784099,-0.013757408,-0.08852015,0.0057509234,-0.025832161,0.07394339,-0.06866054,-0.030470148,0.03322725,0.029308848,0.058716357,-0.005817959,-0.055231016,0.093277104,-0.00509619,0.014801737,-0.0073295445,-0.00892286,-0.0064767967,-0.11317333,-0.028381549,0.069003426,-0.023884766,-0.027309887,0.098327525,0.058153115,0.005588421,-0.0062052156,-0.06033588,-0.035448033,0.056953553,-1.263013e-33,0.037965514,-0.08745413,0.006287237,-0.011351195,-0.01703643,0.07618574,-0.06003468,-0.028248783,0.07427209,0.0015948833,0.10192656,-0.0045183897,0.050290383,-0.08539849,0.03774859,0.08375585,-0.0005453535,0.049706064,0.0032528932,-0.025913564,0.0138117215,0.0570439,-0.022630947,0.055389095,0.027459957,0.016897637,0.020707104,0.027398737,0.06350656,-0.00069250335,-0.037020177,-0.031625655,-0.042629357,-0.007020768,-0.09939251,-0.009918769,-0.084909536,0.01660745,0.0009997975,0.021931399,-0.042387273,-0.017401813,0.03235081,0.030712266,0.11041897,0.061532937,-0.015810383,0.018135173,-0.012331759,0.04670871,0.07768471,-0.000818504,0.056948762,0.028472695,0.07768096,0.049900085,-0.014504474,0.066082485,0.0053650113,-0.030833604,0.0047130967,-0.047593992,0.0016162741,-0.024233982,0.0601478,0.019366441,-0.0775622,0.03774443,-0.02893359,-0.039610084,0.043407947,-0.016654342,-0.029863669,0.02456091,-0.06841608,-0.043203592,-0.020110488,-0.07774747,-0.012141293,-0.03269835,-0.008993499,0.049193032,0.023727458,-0.104627825,0.03419358,0.0022275555,-0.0037732974,0.05414128,-0.0025173733,0.015404011,-0.08208052,0.055535592,-0.040031284,-0.007835342,0.11661976,-3.8876163e-08,0.0020984327,0.013695924,-0.039479703,-0.017348664,-0.016972708,-0.051552936,0.0016061653,-0.05431777,0.018154753,-0.11025332,-0.027029928,0.09300802,0.016052919,0.04177332,-0.002390354,0.015023598,0.029387485,-0.041445907,-0.0036994223,0.005401485,-0.035954986,-0.0054564266,-0.039147098,0.029354548,-0.022172011,-0.021901365,0.050247222,0.043949515,0.016741188,0.07420071,-0.005273167,0.0046081054,0.009903592,-0.037131302,0.07454371,0.020118749,-0.022656683,-0.06925988,-0.028892122,0.09876041,0.046739843,-0.03517148,-0.01198459,0.01938487,-0.06752163,0.012393642,0.017387116,0.054438636,-0.029777769,0.043375373,-0.012192097,-0.046809644,-0.031022435,-0.06339835,-0.12031047,-0.0027269167,0.05148543,-0.055161886,-0.05521609,0.0070476755,0.037757758,-0.022395318,0.20700772,0.013714296 +1.14.19.39,"The enzyme, characterized from the plant Crepis alpina, converts the double bond at position 12 of linoleate into a triple bond. The product is the main fatty acid found in triacylglycerols in the seed oil of Crepis alpina.",384,1.0,-0.0817998,-0.03572606,-0.111934066,-0.034771416,0.014151201,0.09745217,-0.0706509,0.0037333816,0.04539077,-0.0647148,0.067895584,-0.084335946,-0.058312416,-0.09975429,-0.050523676,-0.009667856,-0.031098833,0.013315074,-0.02987581,-0.072731614,0.13661048,-0.013995255,0.009545988,0.03633731,0.011959245,0.016605252,-0.004882878,-0.07525677,0.0418379,-0.042354062,0.01211627,0.0011083225,0.0329566,-0.0091500105,0.015753523,0.050574195,0.010300607,-0.058065742,0.04530864,0.06977293,0.05273248,-0.054745354,-0.0049251257,-0.053329706,-0.012334272,-0.037271306,-0.028331185,0.060674164,0.03890362,0.027099485,-0.0392866,-0.0374622,-0.101818986,0.000774151,0.028402586,0.06656213,-0.025972586,0.06676347,-0.055313278,0.07016535,0.09949999,0.05227189,0.013330653,0.05472581,-0.03990503,-0.110839605,-0.04320356,-0.05930911,0.057376098,-0.018068993,-0.059149306,-0.059310243,0.001624474,-0.040195826,0.018633837,0.06290495,-0.07551021,-0.049107704,-0.0017575189,-0.060524963,-0.031413384,-0.021985758,0.0153743215,0.055819064,0.05118295,0.011013236,-0.012573665,-0.012582674,0.04635109,0.03092789,0.049998496,0.0046720235,-0.077266246,0.0191303,-0.073178895,0.10434425,0.011779014,-0.031253237,-0.056257263,0.009540294,0.01933576,0.06118095,-0.0025200925,-0.13722818,-0.09145117,0.012191924,-0.08586175,0.024222396,0.022575602,-0.013887744,-0.016949832,0.013528268,0.044233494,0.008386303,-0.0067324988,0.027063735,-0.03282632,-0.10111395,0.018131927,0.009740992,-0.006026081,-0.074433126,-0.004061569,0.022690421,-0.026945844,-0.0034030767,-0.04468052,1.9768808e-33,0.0017735799,0.058062885,-0.0162283,0.009219633,-0.10718618,-0.014431396,-0.11829345,0.047780357,-0.14479092,-0.052673124,0.014387517,-0.006957593,0.058537867,0.06479292,-0.08281126,-0.020126238,0.043769605,0.04574854,0.12616429,-0.009290849,-0.03929884,0.0960702,-0.060593646,-0.037622713,0.027298333,0.02703194,0.040575024,-0.0423145,0.05712681,0.027857328,0.025195675,-0.014805732,-0.015420042,0.0014591267,0.0393919,0.044935577,0.014227635,-0.04496893,-0.10643658,0.06547394,0.068815775,0.0025481707,0.08763429,-0.026595768,0.06269882,-0.018806834,-0.013245064,0.035612762,0.07170858,-0.044188477,0.036502037,0.05016586,0.14514224,0.066054985,-0.083139926,0.041250564,-0.058086477,0.02070154,0.0057816594,0.037207793,-0.040622488,0.0754574,-0.036402747,0.016620174,0.021160675,-0.005970243,-0.08734896,-0.09352262,0.04552163,0.09853317,-0.025191862,-0.004488608,0.058763202,0.0365639,0.049694173,-0.038854856,0.012978087,0.02648503,-0.049576085,0.051677056,-0.026675483,0.014809393,0.112942934,-0.066856876,-0.07682915,-0.06372689,-0.06851053,0.017657034,0.021451153,0.023285737,0.01348595,-0.04039337,-0.028435655,0.0069447695,-0.00011389881,-2.424909e-33,0.05110316,-0.0759417,0.036796637,-0.040804945,-0.016974825,0.033532053,-0.03483459,-0.07130128,0.020638853,-0.044570778,0.12923688,-0.028683135,0.075787805,-0.015355955,0.0044936733,0.0501035,0.017801108,0.0045154,-0.012920022,-0.024814826,0.025600782,0.044418145,0.060868718,0.10601185,0.006607727,0.026653897,0.008270455,0.031338125,-0.029323563,0.061920796,0.074139975,-0.12178031,-0.0909735,0.022010596,-0.08378161,0.023844521,-0.067728125,0.01582577,0.02006192,0.034736287,0.028780332,0.017390149,0.043058593,-0.044089977,0.06482712,0.006587489,-0.027118333,0.037140824,0.0032614972,-0.04635614,-0.0018309748,0.033374358,-0.037184164,0.021438863,0.1133146,0.07224615,-0.067842655,-0.006297094,-0.023561597,-0.018090367,-0.024008613,0.007747136,-0.0023852212,-0.030874852,0.07627864,0.06460888,-0.046768792,0.027040927,-0.016255166,0.013353522,0.07112217,0.09187749,-0.023156399,0.0802036,-0.007919262,-0.025005346,0.00200842,-0.07382114,-0.07828228,-0.007360366,-0.02398488,-0.043613743,0.036256984,-0.062119424,-0.06612635,-0.060785525,-0.010306146,0.054493744,0.06361026,-0.013763576,-0.03796813,0.011465953,-0.063973255,-0.0031899095,0.10121419,-3.030065e-08,-0.010644178,-0.02953195,0.054774176,-0.030935721,-0.027990466,0.021808082,-0.021070382,-0.037363432,0.020697327,-0.064003095,-0.102999665,-0.008538415,0.0077263503,0.03839978,0.054805744,0.027496088,0.0004059696,0.037196092,-0.010191238,-0.036373716,0.0024483907,-0.010952889,-0.0123644555,0.04019831,-0.0059863175,-0.053916868,0.010585467,-0.005388226,-0.015404802,0.08589537,-0.000602935,-0.009302954,0.038270205,0.023100356,0.04646915,0.053040344,-0.004325038,0.026734857,-0.06257247,0.107198104,0.043023728,-0.012110496,-0.023182955,-0.019142412,-0.016609214,-0.03666814,0.020236438,0.03553798,0.0040233163,0.006059507,0.02151887,0.0067091454,0.021402892,-0.03655438,-0.02048362,-0.10654472,-0.032868568,-0.06261262,0.0051474855,-0.024899954,-0.0367481,0.02585977,0.159618,0.03862651 +1.14.19.40,"The enzyme, characterized from the marine cyanobacterium Moorea producens, is involved in production of the ion channel blocker jamaicamide A. It is specific for hexanoate or hex-5-enoate loaded onto a dedicated acyl-carrier protein (JamC), which is encoded by a gene in the same operon.",384,1.0,-0.108219095,-0.06286046,-0.09517623,-0.015594782,-0.029468292,0.03123923,-0.0117304,0.013031921,0.0005453854,0.049705856,0.054847743,-0.053364143,-0.056339364,0.012478679,-0.07241986,0.06218561,0.002904374,0.062292155,-0.03482164,-0.04136235,0.0603152,0.06071171,-0.009000082,0.005406977,-0.020604802,0.005108061,0.019681472,0.056168683,-0.022094807,-0.07309869,0.00853394,0.03550594,0.09313582,-0.061619107,0.1152649,0.058760706,-0.0018968236,-0.07596065,0.042598564,-0.0095730685,0.068913735,-0.0073174713,0.019962216,0.07154179,-0.03843299,-0.073472984,0.002291364,0.03717788,0.06243852,-0.043229375,-0.0682114,-0.014555035,-0.046355534,-0.041205563,0.0008465471,0.004841419,-0.09453104,-0.04649148,0.08994706,-0.018627381,0.04810748,0.04571839,-0.006123298,0.059222337,0.041429684,-0.06993036,-0.0056332005,0.00986162,0.021845028,-0.0119878,-0.0017647386,-0.10900687,-0.0238079,0.0432696,0.024677167,0.013256284,0.0038475958,-0.00758289,0.00454603,0.017765678,-0.057873912,-0.050083682,0.013798214,0.015044338,-0.027782615,-0.001924538,0.07277114,0.056059875,0.036888115,0.08276694,0.016910134,-0.0104287295,0.024718137,-0.14094421,-0.03901708,-0.033019114,-0.016963117,0.038859747,0.0057351664,0.010076656,0.035020083,0.032486062,0.0572157,-0.06725946,-0.05635949,-0.009427636,0.028988369,0.11827155,0.0035829616,0.007402324,-0.08465993,0.033551067,-0.060859878,-0.048990157,-0.01812111,0.11026792,-0.0065134764,-0.034110334,0.02457353,0.0020352572,0.00352725,-0.1278873,0.013585835,0.0940433,-0.0212484,0.040540878,-0.14382572,3.6236202e-34,0.042279754,-0.018681142,0.018267957,-0.0084586935,0.003683022,-0.0076401806,-0.055728506,-0.05846148,-0.04123021,0.008210859,-0.14385676,-0.03280537,0.023813661,0.018766522,-0.04872767,-0.024941104,-0.1298178,-0.01841076,0.027858695,0.05896759,0.023100842,0.04640033,-0.008810033,-0.018053686,0.03708332,0.0007062357,0.021481661,-0.1028518,0.05297684,0.023886023,0.019781124,-0.011748492,-0.024964629,-0.036846515,0.10603697,0.0323014,0.0014710514,-0.048457727,-0.005130888,0.050435644,-0.0021618954,-0.01283472,-0.020740889,0.02723476,0.028934158,-0.09546016,-0.050103977,0.021776756,0.053715263,0.012559873,0.083428375,-0.023106748,0.04796483,-0.04293826,0.035623945,0.028799755,-0.015086664,0.08585847,0.029467408,0.08542738,-0.001160152,0.04634113,-0.058301438,0.05185144,0.063873015,0.043940075,0.009051607,-0.018329395,0.0024955142,0.028211836,-0.06522588,-0.1011613,0.09564705,0.053266205,0.0044537373,-0.0205817,-0.11200265,0.017352978,0.013007403,0.01572993,-0.0041049686,-0.07728028,-0.026740637,-0.016590158,-0.11369804,0.008139747,-0.05276998,-0.02487113,-0.010708958,0.02101125,0.09000153,-0.040936124,-0.0057113515,0.049791887,0.026851334,-3.0716957e-33,0.010300764,-0.05758729,0.058374375,-0.007967563,-0.09822999,0.021520745,0.056490034,-0.038029116,0.010062821,-0.0099872975,0.0641101,0.005117022,0.04085519,-0.049173426,-0.03601539,-0.0037826991,0.02011693,0.045423813,-0.042921793,0.026125133,-0.07160586,0.019814016,0.08726288,0.027166154,-0.024098098,0.0127806505,0.015920756,0.1472319,0.03097533,-0.0045983572,-0.012393983,0.06602519,-0.027967205,-0.06042729,-0.056594837,0.027760457,-0.05533639,0.052666478,0.01107676,-0.03213045,0.029637486,0.01937609,-0.017296238,0.07366521,-0.03675952,0.07199933,-0.0033240202,0.07624268,0.062289856,-0.06551335,-0.02025504,0.051797144,-0.004159357,0.035090014,0.012290001,0.11365835,0.028320387,0.0133799985,-0.009087254,0.048319325,0.0051903604,-0.07059858,0.11964133,-0.05549675,0.081264816,0.06852957,-0.0022877872,0.055180095,-0.033023123,-0.014414817,0.034773037,-0.016677903,-0.00940285,0.037251327,-0.0028864215,-0.022071073,-0.09409146,-0.092542104,-0.06976516,0.008517547,-0.023679852,0.03986705,-0.069640875,-0.060592152,0.04863285,-0.01673671,0.07338767,0.07060368,0.02498956,0.003618977,0.039158348,0.0014494428,-0.0999819,0.03900791,-0.03863224,-3.5726114e-08,0.029858993,-0.095217615,0.06439859,-0.08205729,-0.020432474,0.05995506,0.0048030196,-0.016288348,0.029867377,-0.04250552,0.040434886,0.045021206,-0.020332558,0.018346563,0.07760997,0.010643345,-0.048922613,0.029419258,-0.0070269676,-0.055909447,-0.02872617,-0.034938183,-0.0061907,0.051015638,-0.07955436,-0.04644359,0.048208505,0.10791228,0.026388107,-0.036816962,0.00043990326,0.005547548,-0.040789645,0.021614892,-0.09609287,0.05498059,-0.056986686,-0.02527398,-0.04048425,0.019430714,-0.07913758,-0.0076147267,-0.08869746,0.013766353,-0.012563645,0.063579336,-0.055374444,0.08760091,-0.061310157,0.040645834,0.0010763779,-0.012552446,-0.0004476254,-0.11241092,-0.026010364,0.0014532094,-0.01584702,-0.067783035,-0.027669817,-0.016183104,-0.05191852,-0.07354741,0.10785573,-0.05549257 +1.14.19.41,"A heme-thiolate protein (P-450). The enzyme, found in yeast and plants, catalyses the introduction of a double bond between the C-22 and C-23 carbons of certain sterols. In yeast the enzyme acts on ergosta-5,7,24(28)-trien-3beta-ol, a step in the biosynthesis of ergosterol. The enzyme from the plant Arabidopsis thaliana acts on sitosterol and 24-epi-campesterol, producing stigmasterol and brassicasterol, respectively.",384,1.0000001,-0.072762676,0.010464241,-0.100092314,-0.0066312826,0.029369397,0.05762525,-0.06665258,0.091700345,0.054862037,-0.011063413,0.03922583,-0.045345366,-0.16006286,-0.062462263,0.017233394,-0.015589346,-0.0886579,0.04731007,0.018037815,-0.10396234,0.03957318,0.04229012,0.0014830661,0.038592644,-0.004983568,-0.026844937,0.02954244,-0.013137703,-0.03425775,-0.14631484,-0.033160735,-0.073811494,0.08119165,-0.00752914,-0.0071649826,0.09693544,-0.021336693,-0.08987627,0.021341177,-0.032346524,0.10677044,-0.09438549,-0.061913848,0.019014783,-0.04991513,-0.0076481663,-0.04441204,0.08851161,0.017255897,-0.022439186,-0.0013821087,-0.0866627,-0.022030536,-0.009961083,-0.05846173,0.022751868,0.03387024,0.029633319,0.024053667,0.0063918824,0.040146492,-0.010370471,-0.03756207,-0.006216686,-0.08328033,-0.061600495,0.038244322,-0.012956602,0.026100833,-1.20935265e-05,-0.032389127,-0.055974778,-0.10067803,0.060195673,-0.011450234,0.08141894,-0.043281015,-0.022653257,0.0032923606,-0.024229161,0.07844635,0.043201506,0.04811335,0.08187519,0.06516885,-0.0019871616,-0.06963141,0.055757396,0.03132589,0.004234757,0.0599317,0.019073306,-0.019741144,0.057434328,-0.07916405,0.09387299,0.04409204,-0.021387791,0.0016476371,-0.02207722,0.06365792,0.049944803,-0.027833642,-0.053904302,-0.02589442,0.05517805,-0.029527143,-0.024313368,0.0044569056,-0.038171977,-0.016231716,-0.016221065,0.0337643,-0.022520639,-0.051736865,0.056654014,-0.010090216,-0.05827251,-0.044231072,-0.060264427,-0.021006335,9.56014e-05,0.01104978,0.014772998,-0.051792167,-0.039119482,-0.07560741,1.2944512e-33,0.0760192,0.029809857,-0.03133805,0.030548945,-0.0021658614,0.0017735739,-0.048964806,0.07178089,-0.06926157,-0.019119695,-0.06674374,-0.14308983,0.01961799,0.011939609,-0.016656486,-0.005951307,0.017842423,0.084601395,0.08416066,-0.045424707,-0.068636894,0.044053108,-0.08057764,-0.03744585,0.017483799,0.04410792,-0.01133044,-0.028211953,0.05289146,-0.030205041,-0.002670938,-0.07392994,-0.0072988747,0.01777549,0.10185652,-0.0344984,-0.004961076,-0.013469355,-0.050052837,0.023625158,0.010038637,0.0739242,-0.004505839,-0.029083544,0.03319197,0.0036870854,-0.055750456,0.005270704,0.09832341,0.08219163,0.02508597,0.008280197,0.09265253,0.079429165,-0.009188476,0.076045804,-0.031848542,0.072280526,0.021601424,0.018167408,0.046688892,0.124124356,-0.004926173,0.0017460883,0.00055477134,0.08664188,-0.092297,-0.030853238,-0.029642446,0.13405739,-0.009066996,-0.004003057,0.0028322153,-0.04015091,0.040148564,-0.005687621,-0.062030766,0.02979139,-0.013313898,-0.0030893185,-0.003993096,-0.04282731,-0.027944814,-0.03188812,-0.06604177,0.017061276,-0.010184878,-0.010870591,0.013495371,0.032737143,0.0825465,-0.0660116,-0.056373917,0.029125521,0.01373937,-1.5383664e-33,0.088843115,-0.062351458,0.06784882,-0.05514591,-0.020508355,0.019000167,-0.016005887,-0.072939165,-0.03292522,0.010518138,0.08443914,0.020772664,0.015753929,0.001441657,0.018755438,0.03280708,-0.037492312,0.02082956,-0.04887505,0.02043084,-0.058044832,0.050230715,0.01597415,0.15016994,0.022718912,0.031178454,0.05369646,0.011734006,0.06378017,0.0060244133,0.03472801,-0.02216748,-0.039483424,-0.042643216,-0.09150564,0.022384493,-0.01177065,0.0430151,0.01567811,0.002508841,-0.008871274,0.00982904,-0.0010506309,-0.026241235,0.018764222,0.067256525,-0.02807515,0.015651338,-0.04520871,-0.058896553,-0.0069900546,0.029583393,0.0042339847,0.087308116,0.00097178435,-0.040553864,0.04703484,0.01359962,-0.013424218,-0.06120667,-0.0012229637,-0.059268452,-0.023994254,-0.00082158484,0.04693367,0.04684708,-0.050263237,-0.019781917,0.042870954,0.060453948,0.054527313,0.06833938,0.009458362,0.069219634,-0.04160273,-0.01736158,0.049783364,-0.06768556,-0.035870735,-0.039399445,-0.01628699,-0.010136782,0.005488425,-0.08638877,-0.064095855,-0.0768905,0.0065156235,0.11209342,0.020670136,0.0846273,-0.01320552,0.01822439,-0.064968295,0.09902917,0.08462707,-4.1384716e-08,-0.01653224,-0.05632005,0.0052436604,-0.07402428,-0.07939661,-0.02925973,0.07445303,0.004802624,0.0444456,-0.0026224125,-0.06270146,0.08441948,0.041984823,-0.010395153,0.09997673,-0.01666677,-0.015506225,0.06463199,0.0017088504,-0.017704032,-0.005887963,0.03307467,-0.06178212,-0.009978751,0.02045362,-0.0641768,0.037883177,0.039302498,0.05604672,0.014839959,0.06273392,0.04106762,0.025689594,0.035360463,0.051822346,0.07241567,-0.0479924,-0.0589171,-0.027104553,0.017230479,-0.0257064,-0.009586673,-0.08053358,-0.011506048,-0.059443526,-0.012120518,0.06842198,0.07063429,0.02919903,-0.01398143,-0.010361597,0.0061964137,-0.024736993,-0.05697942,-0.09985,-0.010254362,-0.004100145,-0.028107207,-0.0034443194,-0.05909922,0.016641296,-0.08840636,0.20002799,-0.009219117 +1.14.19.42,The enzyme introduces a cis double bond at carbon 7 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in monogalactosyldiacylglycerol.,384,0.99999994,-0.06073219,-0.07803239,-0.10024326,0.039853234,0.018627012,0.03970079,-0.09760911,0.042115714,0.07598994,-0.026427172,0.119657665,-0.017726833,-0.13006563,0.0011767873,0.04113748,-0.03173769,-0.026862783,0.013400289,-0.028960774,-0.030146282,0.09443318,0.045729317,-0.011586188,0.035480317,0.003392087,-0.014107492,-0.016401917,-0.009463063,0.021113163,-0.031810913,0.03159544,-0.008816793,0.04058233,0.0125624,0.057345256,0.015783984,0.046891328,-0.0254714,0.052588884,-0.023356697,0.08402581,-0.08094851,0.025393525,-0.015068535,-0.021877537,-0.039902885,-0.02631237,0.025362805,0.035996355,0.0021496094,-0.019639019,-0.10936511,-0.07933785,-0.07069816,0.0140097365,0.045787755,-0.034828167,0.0038555043,0.0048243464,0.07601931,0.10834133,0.0025307112,-0.00051814184,0.04449759,-0.023906479,-0.10241108,0.033577215,-0.04978471,0.0679908,0.011472048,-0.027118452,-0.0620037,-0.01688952,0.032654565,-0.032482404,0.047764223,-0.03437122,0.016672809,0.03617784,-0.081138566,0.08659169,-0.0048443307,0.06328777,0.097237006,-0.018147413,0.0013586603,-0.0022185126,0.0498281,0.024858069,-0.008048332,0.03690686,-0.039562557,-0.018380383,-0.027340287,-0.097690284,0.061530035,0.03848199,-0.03819126,-0.05952498,0.030576194,0.061463714,0.013835799,-0.05518813,-0.10789091,-0.030457506,0.07710192,-0.08567523,-0.046832584,0.014537993,-0.0010032115,0.0048963847,0.07857881,0.009401547,-0.0120221265,-0.027723636,-0.003043363,-0.02403027,-0.01695253,0.041050117,0.005692429,-0.04859305,-0.05336865,0.026187133,0.01931963,-0.04185125,0.04009297,-0.07824301,3.309054e-33,0.055723015,0.06282109,0.031020839,-0.047058135,-0.003370411,-0.10419633,-0.050630733,0.02220018,-0.16223317,-0.0011036007,-0.015406122,-0.11107558,0.017336806,0.060978606,-0.037586827,0.024052246,-0.014096476,0.02307093,0.09172245,-0.07508018,-0.018495128,0.020576647,-0.02126164,0.008010601,0.027025646,0.09067836,-0.001995863,-0.0116500165,0.11576825,-0.004121576,0.0021529554,-0.055509385,-0.05528831,0.04429047,0.12751263,0.0386354,0.004269732,-0.03482722,-0.006712928,0.024816474,0.008312503,0.01846883,-0.004316736,-0.055641547,0.043056626,0.012765264,-0.10041554,0.046978995,0.07437449,0.007691046,-0.008733751,0.00028683207,0.049493965,0.07314132,-0.04658382,0.04034712,0.023869466,0.077451624,-0.030490912,-0.035052825,-0.034602456,0.007910715,-0.08612293,-0.005809863,0.04792216,0.12570263,-0.14556926,-0.07038414,0.023985405,0.036332946,-0.0093887495,-0.011001399,0.04698726,0.040333726,0.026924444,-0.0153177595,-0.0076864786,0.06171949,-0.055114113,0.09026396,-0.045460876,0.026279084,0.017725592,-0.043400127,-0.11949424,-0.011262636,-0.039613858,-0.057478294,0.009751666,0.015941495,-0.0150668,-0.052880216,-0.01362564,0.05160533,-0.016336156,-4.393397e-33,0.051359326,-0.015675917,0.09487517,-0.037491586,-0.032124106,0.026608147,-0.031322215,-0.08897834,0.005739019,-0.011982194,0.07109135,-0.008567708,0.05305463,-0.032060746,-0.022806684,0.03952171,-0.016358642,0.054830704,0.0042595817,0.0049575465,-0.005402712,0.047433067,0.027465437,0.14024383,0.043847222,-0.018987212,0.023991693,0.060391586,-0.012014884,0.021987403,0.04602955,-0.04301422,-0.06361909,-0.044536814,-0.08058367,-0.01984497,-0.120265484,0.044059865,-0.008772988,0.03288234,-0.010215644,0.033201158,0.044519633,0.018918307,0.06563159,0.0032045871,-0.07032035,-0.02810474,-0.05188595,-0.07255606,-0.058839638,0.026459316,-0.04547903,0.056252107,0.05854613,0.061321866,0.05015253,0.029111605,0.012745039,-0.0746708,-0.030668555,-0.056967463,-0.034003697,-0.008831607,0.0965952,0.080161236,-0.039492562,-0.02999664,0.035507783,-0.0086806705,0.03778262,0.037915174,-0.01868781,0.06409151,0.006835923,-0.012448224,-0.03342547,-0.08631488,-0.08075443,-0.033232372,0.033610553,-0.008385924,-0.03593941,-0.06926903,0.004765908,0.023308238,0.049785573,0.14574762,0.031601626,0.028342692,-0.030622575,0.01064023,-0.078481615,-0.01646515,0.08367423,-3.2601815e-08,0.0020272264,-0.06392943,0.03280442,-0.09731451,-0.060202193,0.026554983,0.06745477,0.018623218,0.040068332,-0.061369456,-0.07475151,0.03373396,0.050092395,-0.0146762505,0.043755785,0.004913634,0.020305254,0.022691835,-0.03151996,-0.03470686,-0.020814953,-0.032474466,-0.04869381,0.018850049,-0.026380848,-0.07372706,-0.009635488,0.06800061,-0.018944528,0.087861426,0.0014268022,0.0052897856,0.0007514115,0.008276373,-0.021981943,0.03240915,-0.013248415,-0.053122193,0.005627993,0.09996074,0.020546136,0.019033644,-0.06404711,0.022510247,-0.023261582,0.0039683958,0.04362191,0.054829426,-0.006250641,0.055990707,-0.017961964,0.026251953,-0.07586252,-0.08312576,-0.09984217,-0.02754008,-0.015998943,0.010477488,-0.037833605,-0.0008292502,0.016420089,-0.06301906,0.14676474,-0.045433167 +1.14.19.43,The enzyme introduces an unusual trans double bond at carbon 3 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in phosphatidylglycerol. The enzyme from tobacco can also accept oleate and alpha-linolenate if present at the sn-2 position of phosphatidylglycerol [1].,384,1.0,-0.07015437,-0.054379832,-0.11229311,0.020424897,0.041204702,0.06593602,-0.091075584,0.025683153,0.058386967,-0.0170649,0.1157532,0.004305817,-0.15400197,-0.0095993895,0.049811482,-0.039075527,-0.05585624,0.026693415,-0.015638582,0.0021894334,0.11347126,0.037352152,0.016737254,0.01139187,0.02659025,-0.021708094,-0.005584966,-0.07623782,0.02881252,-0.0683389,0.023967056,-0.03462406,0.020648696,0.004398052,0.027635176,0.009433362,0.024169594,-0.047670245,0.0364329,-0.034758862,0.10746173,-0.055349234,0.0036245456,-0.042531446,-0.014242064,0.0006400269,-0.044990662,0.045782734,0.030562041,-0.0075295125,-0.029052118,-0.1124318,-0.049981892,-0.08023543,-0.016695002,0.06477113,-0.018384432,0.034972273,-0.0031436067,0.08339539,0.079367764,-0.0027011891,0.004575881,0.05935333,-0.01791856,-0.10635259,0.034351047,-0.045624193,0.029479843,0.019300187,-0.0572121,-0.073369145,0.00090071245,0.037318982,-0.006018608,0.063780665,-0.029958595,0.060158376,0.032371268,-0.06040729,0.066798285,-0.056834552,-0.0026416145,0.11785941,-0.017429829,0.012914301,-0.06985633,0.023311181,0.037984498,0.031856626,0.028294332,-0.022605803,-0.016904926,0.01760429,-0.057127226,0.07455132,0.066370465,-0.017836634,-0.05364572,0.007038097,0.048564076,0.063993566,-0.014963732,-0.1094421,-0.056868702,0.07599764,-0.090449065,-0.0839513,0.023106795,0.00046529656,0.018538002,0.07729162,0.03525701,-0.04212484,-0.06517879,-0.0075202417,-0.023041485,-0.07995464,0.015913976,-0.03903256,-0.040247,-0.088823065,0.011108417,0.023432944,-0.044917934,0.0085268235,-0.04834665,4.4756576e-33,0.055579636,0.06567216,-0.027826216,-0.029709606,0.0036822357,-0.07546031,-0.05787337,0.022709142,-0.14938164,-0.011102235,-0.015648527,-0.09152977,0.0022254402,0.042369712,-0.037167925,0.010397504,0.017951762,0.023479514,0.106139444,-0.06476149,-0.011667123,0.0050241267,-0.03443415,0.01288015,0.019872414,0.062090307,-0.012503879,-0.059974264,0.10515001,-0.010831369,0.052639518,-0.045429535,-0.07285265,0.018709889,0.10018079,0.0010880625,-0.014007819,-0.05343194,-0.022982946,0.009831843,0.02213576,0.021941174,0.029662948,-0.005337803,0.018142067,0.01132078,-0.054642778,0.050447345,0.09915575,0.012462406,-0.0167165,-0.0025410461,0.06882411,0.07052512,-0.027183527,0.04776922,0.007147959,0.045442704,-0.043828405,-0.025746942,-0.023480669,0.05180769,-0.050413944,-0.008252679,-0.016511554,0.08943448,-0.13465416,-0.07235107,0.013498957,0.04741099,0.039270572,-0.028751142,0.028196944,0.05747095,0.026497152,-0.045098685,0.024263255,0.09161695,-0.028821256,0.05303799,0.009085187,0.012789106,0.023026241,-0.031682003,-0.11120078,-0.005580422,-0.045140218,-0.057031486,0.009517625,0.021364562,-0.0033240474,-0.03634032,-0.0042245267,0.06477423,-0.00950825,-5.409307e-33,0.052364185,-0.03278691,0.09226105,-0.03326249,-0.020696398,0.03323309,-0.019101039,-0.016710939,0.030581161,-0.010726266,0.068049036,-0.008435036,0.07560655,-0.049887415,-0.017940143,0.045411102,-0.019934269,0.04092353,6.5195614e-05,-0.0049780267,-0.0037134225,0.05942883,0.018274728,0.12580723,0.058506835,-0.0014683431,-0.007456783,0.07109287,-0.05164427,0.00988632,0.045265634,-0.024331529,-0.05631751,-0.027738148,-0.061671793,-0.024623597,-0.05392446,0.05450049,-0.029586978,0.012943221,-0.0013343198,0.028170696,0.05217728,0.006900504,0.09139654,0.013086231,-0.07714947,0.00707971,-0.06837322,-0.012691456,-0.024873545,0.048316963,-0.02451038,0.068680584,0.06951765,0.07834267,0.039888192,0.04064659,-0.025806546,-0.096784234,-0.011772294,-0.072442584,-0.023008706,-0.01037322,0.09918823,0.07628339,-0.039629873,0.003290075,0.014702734,-0.0008551827,0.0167271,0.03211195,-0.010739899,0.063089736,0.002132038,0.016724903,-0.038862884,-0.10305532,-0.0743608,-0.05449308,0.03183188,0.01521245,0.006798873,-0.083872415,0.011179642,0.021540046,0.024756677,0.104630984,0.0068723853,0.022873946,-0.0518637,-0.016967226,-0.080481306,-0.001376905,0.0848727,-3.9300065e-08,-0.0054160613,-0.036603197,0.0343966,-0.10810471,-0.07591075,-0.008955154,0.06607183,0.014923869,0.021132894,-0.07475378,-0.1232986,0.04893146,0.03887609,-0.017000131,0.06607593,-0.012427249,-0.020126713,0.03053548,-0.05056242,-0.030126855,-0.008802308,0.00906113,-0.057248317,0.023513108,-0.013171891,-0.029306015,-0.0070996345,0.043634225,-0.012271177,0.07662816,-0.0005730249,0.007167316,0.023041783,0.0013773413,-0.034726884,0.002169698,-0.008851961,-0.08215972,-0.041597895,0.11993928,0.014856477,0.0040632663,-0.027230494,0.033388037,-0.044146966,-0.015683929,0.065130964,0.0470142,0.024331346,0.029082164,0.020299293,0.00026479855,-0.086759515,-0.09802537,-0.11146985,-0.094184645,-0.016393876,0.02952353,-0.004889858,-0.01146035,0.024602026,-0.06245802,0.164251,-0.011379913 +1.14.19.44,"The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8. The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyse the desaturation of dihomo-gamma-linoleate [(8Z,11Z,14Z)-icosa-8,11,14-trienoate] and (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome. cf. EC 1.14.19.37, acyl-CoA 5-desaturase.",384,0.99999994,-0.12905169,0.0046389713,-0.09247025,-0.0664573,0.03556655,-0.016580421,-0.04713696,0.053038534,0.00059621123,0.06463849,0.06699813,-0.05302005,-0.11125051,0.055458866,-0.015434323,0.031207558,-0.037872907,0.03563965,-0.016370017,0.02128341,0.10433673,0.02270455,0.018562706,-0.008825926,-0.03190381,0.012475746,0.07946286,-0.02974251,-0.020299165,-0.08789055,-0.0058443584,-0.03890931,-0.017176209,-0.01732463,0.046487574,0.011729466,0.0006504238,-0.07922583,0.030936262,-0.0015247436,0.05382777,-0.029867902,-0.02426809,-0.060923282,-0.07144026,-0.08794001,0.0048652105,0.044547483,0.05802158,-0.044041246,-0.0017490786,-0.020958897,-0.07465076,0.063476466,-0.042729877,0.0110551445,-0.015596222,-0.05904073,-0.080131665,0.009633983,0.06945672,0.015404354,-0.06849857,-0.017509257,-0.04082964,-0.059268527,0.0054524154,-0.02018542,0.009269453,-0.013450689,-0.044603985,-0.08740059,-0.012989277,0.03046916,-0.05947083,0.07815353,0.05533797,-0.022732278,0.0031233048,-0.053146586,0.0013888967,0.04547216,0.08612286,0.07840274,0.0593993,0.017858166,0.010660807,0.1034732,0.08370779,0.045083717,0.081987545,0.054048017,-0.036181856,0.0009562891,-0.117242284,0.046825055,0.094661385,0.058994554,0.0031835358,0.024192926,0.081027284,0.040338635,-0.021845374,-0.094757475,-0.056397203,0.026082331,-0.02078372,0.06361183,0.016916968,-0.012734463,-0.043335773,-0.025444312,0.01636116,0.050843142,0.02056013,0.07753881,0.00027656642,-0.0680302,0.027924927,-0.0025958386,-0.011889308,-0.030657327,0.053346124,0.0824266,0.020082017,0.053929836,-0.11259449,9.526339e-34,0.058155615,0.069832265,0.021965435,0.038437746,-0.04148923,0.016266774,-0.1119725,0.061468992,-0.1917279,-0.015757838,-0.063252255,-0.0053251605,0.043331,0.011750065,-0.013378304,0.022748971,0.02372686,0.017017426,0.056367233,0.02209527,-0.009929613,0.06198618,-0.081962466,-0.016455868,0.045678347,0.09657938,-0.03605208,-0.0046393964,-0.03959194,0.014662139,-0.022876682,-0.09600956,-0.079823494,0.04893239,0.052979093,0.024879694,-0.0013536287,-0.011080068,-0.033429693,-0.0049416223,0.07902875,-0.026431821,-0.015573903,-0.019292438,0.06519447,-0.037631806,-0.052982885,0.045519106,0.05479252,0.051171504,0.04708672,0.031095212,0.034665376,0.030806191,-0.15890093,0.10752055,-0.009010338,-0.01680284,0.05994326,-0.0037917218,0.014004392,0.016608804,-0.08113473,0.0114832,0.025236603,0.048376523,-0.02782664,-0.02907495,0.022739831,0.083398685,-0.11138472,-0.02814543,0.104849346,0.031507213,0.066867836,0.010503317,0.010592074,0.03204212,0.028578488,0.093317345,0.003405205,-0.0045338613,0.045651365,-0.07354625,-0.07229743,0.043957368,-0.024905179,0.015331843,-0.0022388017,0.002698075,0.08769375,-0.06527846,-0.024441322,-0.05678152,-0.010605614,-2.4574604e-33,0.13444039,-0.10569883,-0.034513414,-0.104863346,-0.042492207,0.015621505,-0.02819216,-0.061609745,0.022339446,-0.083014235,0.115751125,-0.015199177,0.07904866,-0.020738764,0.049518317,-0.0020595836,-0.0333729,0.043966938,0.07668623,-0.0039790436,0.0068677794,0.04775577,0.024481496,0.016861204,-0.005073307,-0.037041016,0.03197915,0.025322124,0.05837916,0.024063224,0.0004932839,-0.01732644,0.00063518225,-0.049631983,-0.06386123,-0.006350905,-0.08822991,0.003312441,-0.02177636,0.11560465,-0.06056347,0.0042739836,0.0061339187,0.005940515,0.031778015,0.08036771,-0.062141314,-0.0065998114,-0.025096435,-0.016596096,0.059616648,0.010592612,-0.025499452,0.0005455085,0.03134634,0.045456447,-0.0052306363,0.013596598,0.010046069,0.01011968,0.032676097,-0.039944686,-0.028649436,-0.07119927,0.074585125,0.042294357,-0.09729841,0.030393466,-0.04052004,0.017861648,0.039888132,0.019723048,-0.011425021,-0.0020034527,-0.012196786,-0.011102056,-0.037311792,-0.07229051,-0.021138763,-0.027311116,-0.070644036,0.013722964,0.018522922,-0.011156861,-0.06991161,0.007258849,0.008266123,0.101389214,-0.024748076,0.029537313,-0.029359203,-0.027396971,-0.030056661,0.1034641,0.04971847,-4.882772e-08,0.009008317,0.0019040619,-0.028791754,-0.038031,-0.0018672041,0.0060206987,-0.005559901,-0.054673634,0.09487647,-0.045610648,-0.02089553,0.06799441,0.03450724,0.07007412,-0.00030271633,0.033133954,0.031789403,-0.035647184,-0.020973206,-0.029021302,-0.046805605,0.017995687,-0.06893307,-0.029747041,-0.021568114,-0.0026022673,0.038495835,0.055511434,0.015504672,0.023983624,-0.06847809,0.019737426,0.023760071,-0.024345858,0.026705118,-0.0034405238,-0.044701625,-0.10133203,0.0137154255,0.015980046,0.09383171,-0.051854286,-0.025348574,0.038464047,0.016406301,0.0103995735,0.07319404,-0.015270209,0.022480473,-0.008188341,0.0038626925,0.057011075,-0.036248196,-0.1020958,-0.07982445,0.009774684,-0.05267676,-0.046679437,-0.06203461,-0.040965408,0.02117697,-0.017855322,0.1235683,-0.049773727 +1.14.19.45,"The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 12 of oleoyl groups (18:1) attached to the sn-1 position of glycerolipids. The enzyme is a methyl-end desaturase, introducing the new double bond between a pre-existing double bond and the methyl-end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid.",384,1.0,-0.1270399,-0.00027398876,-0.105258055,0.041375067,-0.015219603,0.027270032,-0.08555097,0.07689241,0.0015409548,-0.054078087,0.08322708,-0.0699527,-0.12781648,0.023479246,-0.001511741,0.004661675,-0.03372007,-0.00095669634,-0.017565858,0.037761167,0.09117679,0.05635942,-0.047646824,0.059286788,0.031030133,0.03570211,0.01738887,0.0052628857,0.009543995,-0.014050063,0.045614913,-0.08901526,0.0448995,0.009885521,0.0779319,0.013081828,0.027038494,-0.06512395,0.0632804,0.00352876,0.09633649,-0.008777217,-0.023332812,-0.007277245,0.017200846,-0.028635316,-0.028839102,0.041276213,0.015947685,-0.041374475,-0.002318292,-0.09396998,-0.08483934,-0.007964005,0.0065399567,0.03257965,-0.08800084,-0.025520153,-0.040502932,0.023039045,0.1161928,-0.006730404,-0.0142268,0.040704645,-0.009820668,-0.08123903,0.015783396,-0.09039361,0.057533987,0.007848557,-0.07281113,-0.07942413,-0.06159766,0.027712531,-0.02561169,0.039269634,-0.010660427,0.0010960571,0.043849308,-0.054135613,0.049794547,-0.012518885,0.040302917,0.0736265,0.013916577,0.0034689982,0.005857962,0.01797768,0.013326351,0.023842532,0.035340667,0.023983343,-0.013727607,-0.025283914,-0.090359144,0.02293679,0.04720551,0.027145024,-0.02003564,0.04621793,0.046082553,0.03066776,-0.056085248,-0.120668225,-0.055609044,0.02071084,-0.0131157525,0.0005117409,0.022122255,-0.017993614,-0.014702371,0.027772011,0.020204546,-0.0015797443,-0.02989106,0.03984767,-0.019975808,0.00072684593,0.060536657,0.012832096,-0.020481456,-0.08212672,0.029270304,0.05407207,-0.03861108,0.030145016,-0.124579914,-4.7466574e-35,0.053334486,0.009587116,0.03495145,-0.041493222,0.006359547,-0.038031768,-0.087126315,0.030820241,-0.15091158,-0.033331867,-0.051871687,-0.024065142,0.030139493,0.058181327,-0.08775432,-0.019059323,0.0023294338,0.07575893,0.11207855,-0.01870632,-0.016203562,0.067700885,0.010256589,-0.04152061,0.035343096,0.06845558,-0.06580419,-0.005865643,0.0719677,0.021863712,-0.03300082,-0.11121765,-0.0841613,0.040931463,0.12199822,0.038831826,0.00094437145,-0.045986395,0.04190443,0.045938306,0.017428877,-0.008381699,0.0029098187,-0.03292643,0.030383535,0.020239742,-0.07407552,0.046341106,0.05822439,-0.020342723,0.0027554156,-0.0382325,0.016137358,0.008910354,-0.085767016,0.04414587,0.020337643,0.07586889,-0.046549216,-0.0072445674,-0.038491677,0.1005823,-0.08914403,-0.009651867,0.06599382,0.025385333,-0.08842787,-0.0031886615,0.014034559,0.035220854,-0.03878109,-0.0062166126,0.08970983,0.036509708,0.008614616,-0.037578333,-0.023672048,0.054951414,0.013320888,0.10143326,-0.05683731,-0.0031180417,-0.007557231,-0.13085103,-0.10247109,0.008214463,-0.032388356,-0.06571308,0.051798563,0.0672082,-0.01606499,-0.074218534,-0.034993082,0.025719354,-0.0040127896,-2.9232307e-33,0.064978495,-0.08474005,0.03945139,-0.028357027,-0.025544137,0.032114353,-0.030253,-0.068140335,0.03710766,0.013167272,0.13732697,-0.015420342,0.08296099,0.0019319631,-0.0039444263,0.05230741,-0.04103476,0.05104611,-0.011947904,-0.03858834,0.0055828807,0.0120503865,0.032057066,0.10699547,0.041925844,-0.0020242648,0.008712436,0.06500905,0.013593661,0.021723097,-0.008519183,-0.031214045,-0.04688955,-0.09316212,-0.043811716,0.05432428,-0.073368154,-0.015906723,0.02844393,-0.015811156,0.012478525,-0.0026549133,0.027914805,0.062631354,0.08070249,0.033389196,-0.04721379,-0.013800124,-0.03744161,-0.049137924,-0.009643375,0.01872574,-0.010474858,0.052155714,0.024904817,0.052289326,0.02633928,0.06720161,-0.026336549,-0.023852572,0.0063306247,-0.083713345,-0.04706436,-0.032265734,0.075250246,0.042923212,-0.04491607,-0.05640929,0.024791524,-0.036708366,0.07739586,0.023665074,-0.051474996,0.0010978221,-0.057462122,-0.0033168348,-0.027411137,-0.11769667,-0.07798557,-0.017498713,0.0049753785,-0.030400537,0.0048580114,-0.044450745,-0.0015919906,-0.020223193,0.030352572,0.14659466,-0.04025635,0.04631646,-0.056588918,0.032284137,-0.08321254,0.07638589,0.047060825,-3.9396845e-08,0.02051236,-0.085444555,0.030834127,-0.07488287,-0.02122776,0.04007683,0.0145387715,-0.047182962,0.024599735,-0.06651468,-0.028165912,0.050238017,-0.0040308437,-0.023174573,0.04526936,0.0380622,-0.036095694,-0.0063500684,0.009304258,-0.022330426,-0.021094859,-0.030480813,-0.043639358,-0.00546136,-0.017945604,-0.06517956,0.029553458,0.11808617,-0.01721123,0.05490472,0.02345294,-0.0036548902,-0.021289561,0.055762976,0.017824193,0.010487784,-0.037596703,-0.038273957,-0.020821681,0.09050659,0.037141092,0.027135976,-0.086178645,0.05373296,-0.010258612,0.033867866,0.049104985,0.069844924,-0.04452714,-0.010006216,-0.017604325,0.020500898,-0.047665853,-0.024978114,-0.1199483,0.020433284,-0.014315781,0.013380136,-0.097862765,0.041452028,-0.0035983215,-0.01590352,0.17236252,-0.011225394 +1.14.19.46,"The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 6 of linoleoyl groups (18:2) attached to the sn-1 position of glycerolipids. The enzyme is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid.",384,0.99999994,-0.12514654,-0.03311269,-0.10159083,0.03039677,-0.012794599,0.0427517,-0.090946704,0.0714614,-0.0017902734,-0.05545646,0.06930178,-0.0582936,-0.12911735,0.023492271,0.0059766835,-0.009047906,-0.02851552,0.00733691,-0.011273293,0.037796292,0.09092583,0.047303617,-0.0440389,0.07336153,0.05225753,0.017437296,0.019161213,-0.007948781,0.00268848,-0.03588237,0.04425299,-0.09516697,0.042016186,0.027380314,0.086710356,0.009498751,0.02972552,-0.03813882,0.06569228,0.0018769588,0.093328446,-0.0065739728,-0.015855182,-0.0050691157,0.030885553,-0.017829744,-0.029100724,0.049583998,0.023881884,-0.032873116,0.0050146533,-0.10013313,-0.07512133,-0.031075021,-5.643446e-06,0.047146052,-0.09928856,-0.030104736,-0.034725588,0.02452952,0.1411545,0.007035986,-0.008406452,0.050562095,-2.961259e-05,-0.094000645,0.018308088,-0.089259386,0.08106118,0.004191502,-0.06378008,-0.07565761,-0.057442702,0.014177182,-0.0376801,0.029373016,-0.029549606,0.0018104085,0.04961142,-0.057436466,0.060554795,-0.008800034,0.05309323,0.087075055,0.005164776,0.0043052738,0.0056554256,0.015477738,-0.0068111694,0.0060421685,0.05322547,0.0064196945,0.0036860434,-0.0060517048,-0.11091061,0.024114482,0.04972143,0.024431761,-0.017838567,0.049253486,0.059388965,0.025848228,-0.019383108,-0.110160105,-0.04037438,0.005411825,-0.03235072,-0.01067683,0.02643476,-0.0047019445,-0.032695096,0.03380605,0.02780005,0.022549886,-0.02116608,0.033331912,-0.009749736,-0.0017270187,0.054578155,0.015193825,-0.0014049632,-0.09009712,0.029396776,0.041535795,-0.040335402,0.054120265,-0.105888054,5.4356103e-34,0.060502384,0.006142411,0.046761163,-0.02765039,-0.013060103,-0.053275496,-0.089546934,0.015194451,-0.16618894,-0.0120900255,-0.04861903,-0.014555967,0.03565919,0.06293691,-0.079844855,0.008382615,-0.0059475545,0.079796165,0.12411168,-0.011226982,-0.025074147,0.08107226,0.0046325307,-0.017595077,0.043358956,0.051883284,-0.055703055,-0.008394535,0.07008048,0.024318125,-0.0390091,-0.10360504,-0.07107234,0.04182971,0.11867194,0.010188396,-0.0042270846,-0.058483157,0.027208738,0.0486041,0.015611767,-0.00897426,0.0005822933,-0.05694337,0.0408602,0.009065704,-0.0821343,0.05364711,0.04844447,-0.022224458,0.012204123,-0.03208152,0.011706313,0.031384006,-0.06043887,0.04807793,0.026688682,0.07863576,-0.031693332,-0.007338983,-0.020158324,0.098776884,-0.08760302,-0.026069421,0.07363625,0.028875198,-0.10313531,-0.001583999,0.01626006,0.051092226,-0.048739787,-0.010909895,0.071943715,0.049025368,0.01282768,-0.049859732,-0.032819595,0.055993333,0.0040625087,0.071698904,-0.0633949,0.009730399,0.0043507866,-0.11133766,-0.0907754,-0.0012795484,-0.03307511,-0.065514706,0.046589218,0.06095489,-0.015755028,-0.068344064,-0.044786226,0.029879453,-0.0117849745,-2.9049704e-33,0.07224659,-0.08382044,0.02712767,-0.0061588855,-0.014003149,0.038488,-0.033438493,-0.09601486,0.04857014,0.0211184,0.121319495,-0.016801404,0.09406568,0.004718972,0.018599236,0.0493085,-0.027585542,0.036068004,-0.024738807,-0.04182555,0.018481022,0.0041134967,0.027865555,0.08691476,0.024821864,-0.014096343,-0.00095996296,0.06021028,0.0034839548,0.026117006,-0.0029299362,-0.033400465,-0.045961633,-0.12142174,-0.06423167,0.02289723,-0.07049115,0.0071063004,0.019096691,-0.03709457,-0.014142756,0.008991705,0.03964078,0.05040773,0.094527766,0.020393083,-0.035984952,-0.03189435,-0.03110375,-0.03527823,-0.010988365,-0.00062631146,-0.007829973,0.05611782,0.016502084,0.056022964,0.028408973,0.062325016,-0.015772834,-0.010113385,0.004671402,-0.089587934,-0.054320443,-0.0494841,0.06724378,0.037979923,-0.06647985,-0.035203297,0.028588165,-0.04600872,0.06822299,0.028987091,-0.039303612,0.011641141,-0.05669651,-0.0046764496,-0.018513031,-0.115721405,-0.043384027,-0.018530112,-0.007466407,-0.009839071,0.0073459973,-0.0343221,0.0038197222,-0.020133156,0.04803629,0.15238263,-0.03108709,0.03128099,-0.050260734,0.016267838,-0.08250285,0.049781967,0.04903313,-3.9460385e-08,0.041057363,-0.080843106,0.01870131,-0.08202081,-0.027914712,0.02603673,0.011093232,-0.04011218,0.012988892,-0.09024428,-0.016807223,0.05697559,0.0019000767,-0.02708414,0.05789994,0.050549418,-0.022866989,0.0066457824,-0.016735913,-0.025656508,-0.0019286621,-0.020235687,-0.05712636,0.0068363706,-0.008790451,-0.067488655,0.040777076,0.09302436,-0.016705118,0.07205056,0.003975498,-0.016201807,-0.0061961305,0.046192646,0.023398886,0.009377633,-0.04823328,-0.035635702,-0.008398563,0.094186746,0.042234812,0.00956804,-0.07758227,0.047843087,-0.017545002,0.034876306,0.03571134,0.057563044,-0.05165688,0.004366627,-0.037150886,0.011799511,-0.050365828,-0.015686385,-0.10753722,0.036914375,-0.0072659585,-0.0011541877,-0.104343064,0.0246553,-0.007908883,-0.017339556,0.17665923,0.00093695684 +1.14.19.47,"The enzyme, characterized from the moss Physcomitrella patens and the plant Borago officinalis (borage), introduces a cis double bond at carbon 6 of several acyl-lipids that contain an existing Delta9 cis double bond. The enzyme contains a cytochrome b5 domain that acts as the electron donor for the active site of the desaturase.",384,1.0,-0.1169823,-0.03469637,-0.1360515,-0.0061313724,-0.0077498234,0.008280685,-0.03503819,0.051676355,0.01601468,-0.06779258,0.084099814,-0.030206338,-0.12935317,-0.0073111528,0.045610532,0.020893548,-0.043631747,0.04436303,-0.06466729,-0.014735708,0.116625644,0.06705956,0.012574777,0.05910998,0.03684432,-0.07600493,0.026244503,0.016309356,0.0031980409,-0.06380366,0.008100462,-0.0036637536,0.012006441,-0.029729847,0.08007275,0.046255443,0.019241264,-0.070280455,0.09517304,-3.4541954e-05,0.07540288,-0.004851861,0.00495356,-0.0008204532,-0.038795065,-0.07981957,-0.023235101,0.08391784,0.048402358,-0.02767288,-0.030610638,-0.049741495,-0.098958865,0.019998852,-0.05838988,0.04424521,0.023303913,0.03374509,-0.024721699,-0.0012586651,0.09730104,0.034166783,-0.01682325,0.025017686,-0.0029937557,-0.052686453,-0.011126275,-0.06895987,0.042286023,-0.04308455,-0.015317933,-0.057820912,-0.042565655,0.045370635,0.0041782963,0.01733108,-0.059191626,-0.051035717,0.01851061,-0.033299275,0.04693786,-0.02273964,0.04785331,0.11372304,0.01965714,0.019609086,0.013386207,0.050156172,-0.014615508,-0.038363747,0.043291368,-0.01810386,-0.034858245,-0.030024532,-0.14996566,0.091417335,0.062166274,0.01566157,-0.039088693,0.02518126,0.014942553,-0.013739773,-0.062943414,-0.0910496,-0.050856195,0.0052385014,0.0017207986,0.012804787,0.0051412648,-0.031876776,-0.015191762,-0.02171924,0.03866696,-0.009085964,-0.01594511,0.064324945,-0.021586873,-0.045470152,0.046695724,-0.08819736,-0.009772855,-0.003534655,0.029244449,0.04826782,-0.020042585,-0.006394066,-0.13881148,2.8999958e-33,0.06991929,0.029502368,0.05661627,-0.002339338,-0.030213598,-0.062022682,-0.1062314,-0.024897981,-0.17226005,0.029901844,-0.09081757,-0.081335366,0.058652993,-0.0052267453,-0.0006783607,-0.024435366,-0.001150953,0.05821751,0.113475375,0.052643176,0.060165647,0.13441195,-0.048014604,0.049359858,0.04502296,0.08854427,-0.006857269,0.007647371,0.026115702,0.033184648,0.04646902,-0.029611045,-0.079983525,0.014018077,0.09813071,0.0014178228,-0.037010267,-0.02438407,-0.049301088,-0.008066649,0.039014187,-0.0036647469,-0.015003201,-0.01768983,0.07765027,-0.07959499,-0.08158325,0.030458387,0.08683557,0.042812847,-0.011758898,0.0074276733,0.047843643,0.06494912,-0.078191616,0.036629923,0.021334702,0.032528546,-0.006192656,0.050872758,0.01867306,0.025696917,-0.08426641,0.007305113,0.028115645,0.03156664,-0.061710786,0.00058486173,0.032590233,0.07485718,-0.07835713,-0.04612028,0.051551003,-0.001347083,0.03572001,0.012999263,-0.022253362,0.029695472,-0.009340839,0.056701206,0.0026717293,-0.063681275,0.072467275,-0.05361376,-0.08375547,-0.008502243,-0.021111768,0.0022584829,0.036935173,0.073848076,0.04305525,-0.07261442,-0.040026173,-0.035331503,0.0109528415,-2.7642934e-33,0.07472515,-0.06793996,0.031176839,-0.060578845,-0.05266002,0.003015265,-0.0010548995,-0.10213592,0.02766959,0.004062088,0.10842199,-0.0014732204,0.026351154,-0.038219374,-0.013076374,0.0345209,0.008468216,0.045175333,0.02874872,0.013300891,-0.037743144,0.033227433,0.038646534,0.0232018,0.037233163,0.002126894,0.04338074,0.044764977,0.028634325,0.016667286,-0.01806406,-0.031152463,-0.025069602,-0.010948188,-0.09853771,-0.008047599,-0.08008697,-0.017134888,0.00023921161,0.03718193,-0.037963953,-0.0025444063,-0.009836496,0.053917583,0.068675935,0.01771973,-0.08173085,0.039132845,-0.044671163,-0.013302543,0.03853539,0.016471734,0.044467103,-0.0098636225,0.06694812,-0.013622075,0.013028221,0.07490864,-0.024375819,0.031086924,0.017023932,-0.0045348625,-0.0272413,0.027254188,0.08574412,0.07336208,-0.08206212,-0.0026529992,0.0034869048,-0.037020605,0.010376367,0.056941446,-0.017069738,0.022504764,-0.050696608,-0.015051736,-0.058484264,-0.094195105,-0.01913775,0.055307,-0.06763266,-0.008557092,-0.014469468,-0.024182647,0.012031918,-0.023400703,-0.04721497,0.1318788,0.058281653,0.018657383,-0.04107412,0.0165277,0.016720904,-0.0018893307,0.15991458,-3.6902357e-08,-0.031071378,0.008704397,-0.002915999,-0.055010006,-0.012820523,-0.05069797,-0.02425868,-0.071593724,0.020332972,-0.03521324,-0.03267354,0.09148934,-0.005085098,-0.0044998704,0.021916194,-0.008629643,0.05517718,-0.0057399576,-0.022870502,-0.019062132,-0.0114972945,-0.016010167,-0.13615628,0.03788145,-0.0072750426,-0.040466156,0.010259699,0.03694089,0.08295178,0.053742956,0.057478618,-0.04848335,0.03239082,-0.036346138,0.022304999,0.020856136,-0.065566175,-0.017391134,-0.0011789703,0.07105562,0.07264733,-0.076077856,-0.069700055,0.039499365,-0.022485169,0.06866969,0.010459184,0.05081417,0.0018222391,0.03511429,-0.019321246,-4.986687e-05,-0.022251183,-0.043464743,-0.114507444,0.043588232,0.010638671,0.0037624228,-0.024563847,-0.0005325118,0.009683672,-0.0032085732,0.18293685,-0.046554774 +1.21.99.4,"The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.",384,1.0,-0.030599935,-0.07527525,0.016551018,-0.024574291,0.08080454,-0.0068124495,-0.019780872,0.018943133,-0.019161208,0.0077892146,0.02641971,0.0014701518,-0.045810517,0.0041567152,-0.016731482,0.037957188,-0.048545852,-0.044720005,-0.02629769,-0.09340944,0.011449091,-0.053889543,-0.016438793,0.017323108,0.081547074,-0.023453664,0.04181674,0.005338398,-0.053489197,-0.06073593,-0.0079026725,-0.06323192,0.03611382,-0.034957238,0.03263296,0.07941619,-0.05616087,-0.03883006,-0.017925473,-0.013329402,0.052877672,-0.11646664,-0.057831373,-0.04140837,-0.028490974,-0.06034389,-0.07708058,0.003123199,0.024652671,0.0615715,-0.01783656,-0.048643067,-0.03473254,0.064007126,-0.03249737,0.042353783,-0.055061944,0.09861481,-0.074143894,0.027133176,0.021802418,-0.01826598,0.021118034,-0.03524389,0.11444514,0.046600536,0.033584733,-0.10459515,-0.03737064,-0.047478866,0.05526285,-0.087265514,-0.029245747,0.002374943,0.034919478,-0.068401285,-0.07837738,-0.049040448,0.03164516,0.011204217,-0.03155732,0.0054387907,0.12006519,0.020612137,-0.0015644432,0.071931794,0.026637867,0.019377878,0.0130158635,0.06039109,0.011096556,-0.008210911,-0.09355133,-0.040855218,0.04828743,0.0338441,-0.06552557,0.056737494,-0.002421472,-0.0140911685,0.007025373,0.049645063,-0.13728236,-0.043364003,-0.026688524,0.049103543,0.036586262,-0.008094379,-0.05510693,-0.009550076,-0.008701814,0.007067082,0.029947154,0.05767839,-0.071125254,0.10272028,0.003557801,0.07456686,-0.04359422,0.0036999902,0.09191927,-0.00044672214,0.04597837,0.05514881,-0.032457855,0.051375158,-0.10639052,1.4451627e-33,0.06022222,-0.0055316384,0.05292358,0.016987635,-0.0044307923,0.033243228,-0.053662177,0.07058374,-0.041084882,-0.042285684,-0.04004615,-0.07225046,0.05249771,0.026469646,0.0012428389,-0.09765381,0.04432031,0.03826567,0.027116334,-0.027073205,0.10714305,0.087037675,-0.025323031,0.02964142,0.04640805,0.06010432,-0.04868165,0.08622173,0.014320505,0.023761507,-0.0071509746,-0.14999045,-0.06925914,-0.015348342,0.07776126,0.0026162642,0.020067967,0.01188839,0.015379208,0.06998583,0.0052073738,0.01693937,-0.0072208736,-0.008675152,0.0069920504,-0.024876822,0.021802083,0.021485802,0.043825857,0.019499123,-0.008296019,-0.04857669,0.051900845,-0.049179357,0.014874091,0.017840378,-0.013010013,-0.024652025,0.03164143,0.09287926,0.009193436,0.040871378,0.0110526625,-0.036580145,0.026727276,-0.0025614477,-0.13199598,-0.06842204,0.0036755186,0.082883075,-0.08287342,0.053697545,0.025686866,0.011249563,0.07298303,0.015680404,-0.08597637,0.038776044,-0.015918339,-0.06568748,0.0386002,-0.0397161,0.0137497485,0.0014737237,-0.0026653241,-0.04012479,-0.08381731,-0.07662591,0.017265039,-0.021392241,0.0860841,-0.03510859,-0.039795563,-0.074186616,-0.011743327,-2.3767214e-33,0.031709503,-0.069545336,-0.042848933,-0.04992978,-0.07219303,0.067656875,0.034348164,-0.040900573,0.070171565,0.06127566,0.07406769,0.024483541,-0.05474092,-0.019327406,-0.03607084,0.04580766,-0.0027381878,0.051330756,0.041670464,-0.033786684,-0.05415681,0.07003902,0.058671895,0.0015422748,0.09433053,0.044581477,0.027695801,0.07887483,0.10079028,0.043756507,-0.0687586,-0.033882435,0.0015356106,0.006633757,0.03286596,0.060873993,-0.09102058,-0.010648395,-0.020883111,0.017082157,-0.028098319,-0.006606723,0.05253038,0.011761445,0.0064294245,-0.042999808,-0.103999674,0.124766864,-0.024845552,-0.09208691,0.045974825,-0.044388335,-0.019015424,0.010028008,0.022564828,0.01966015,0.028285148,-0.00762839,-0.07130247,-0.008833195,0.02626882,-0.04146063,0.008594123,0.000401605,0.020446364,-0.004861662,-0.011566109,-0.0049742945,-0.008071093,-0.00034617182,0.04777218,-0.03264397,0.010408694,0.0300039,-0.08229285,-0.0887537,0.0157276,0.0430596,0.059902553,-0.02023828,-0.07974426,-0.015771667,0.0056880265,-0.12646039,-0.0022355537,-0.021486906,0.0029999344,0.1039802,0.025709402,0.03814909,-0.0559994,0.021779273,-0.04147077,0.10996345,0.057551146,-4.083278e-08,0.08474012,-0.09359143,0.063111134,0.007197428,0.07703694,-0.006798723,0.031557895,-0.07279704,0.029861199,-0.035004552,-0.09170862,0.08843646,0.047951728,-0.03122391,0.11160962,0.0032236867,0.026352242,0.050801773,-0.026714105,-0.043814164,-0.044650946,-0.038474433,-0.078631066,-0.035802506,0.02787064,-0.005594127,0.039016634,0.035265572,-0.00021047844,0.016353048,0.00789632,0.0053047366,0.018200044,-0.06252887,-0.05480967,0.010486358,-0.08621878,0.03925775,-0.001466617,0.015969623,-0.048928753,-0.01904867,-0.019381369,0.02793217,0.034864925,-0.0049580657,0.04902002,-0.062278967,0.026185097,0.009249627,0.010538614,-0.02905582,-0.02088939,0.049860872,-0.036374785,0.10000021,-0.0134529425,-0.12667274,-0.021058787,-0.04332886,0.023279944,0.045887146,0.15615101,-0.04200041 +2.1.1.319,"This eukaryotic enzyme catalyses the sequential dimethylation of one of the terminal guanidino nitrogen atoms in arginine residues, resulting in formation of asymmetric dimethylarginine residues. Some forms (e.g. PRMT1) have a very wide substrate specificity, while others (e.g. PRMT4 and PRMT6) are rather specific. The enzyme has a preference for methylating arginine residues that are flanked by one or more glycine residues [1]. PRMT1 is responsible for the bulk (about 85%) of total protein arginine methylation activity in mammalian cells [2]. cf. EC 2.1.1.320, type II protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase.",384,1.0,-0.026427355,-0.08117043,-0.113387294,-0.060793806,0.021059984,0.009392926,0.06899427,0.06450905,0.041986365,-0.018277373,0.06209838,0.034784652,-0.040810905,0.03770436,-0.011452343,0.05654648,-0.10487569,-0.05557853,0.046243053,-0.022459997,0.023220135,0.054956082,-0.08556444,-0.052141644,-0.013401982,-0.048853796,0.029416982,0.022360373,0.06070228,-0.058798343,-0.03414489,0.016339557,0.030914988,-0.009358526,0.07318989,0.08186888,-0.06252612,-0.05295101,-0.028449602,-0.05258294,0.10133556,0.03763189,-0.034215666,-0.03529726,-0.03729877,-0.013351899,0.10153458,0.023981906,-0.025013689,0.00048396495,0.016844416,-0.019824814,-0.0023125706,0.020586168,-0.0030099463,-0.020776635,-0.1598509,-0.008245314,0.015057056,0.013938926,-0.049406208,0.007813943,-0.041352406,-0.1054747,0.051455736,-0.04560957,0.12633789,-0.08484387,0.038864423,-0.014069867,-0.04699936,-0.012196505,-0.054679893,0.0630902,-0.066577256,0.052241057,0.0025907324,-0.017993947,0.010894986,-0.05810139,-0.018946795,0.0544141,0.086270556,-0.015442355,0.03654417,-0.027159732,-0.042022515,0.107467726,0.061497938,-0.005267659,0.04121884,0.04253722,0.0033039923,0.021700671,-0.0052069975,0.054715723,-0.025592584,0.019333836,0.048601773,0.015333289,0.059422534,0.101378836,-0.07469927,-0.026961213,0.0992157,0.06635366,0.03268928,0.074649855,-0.027304675,0.027036456,-0.033600982,0.04369295,0.05365975,0.03914552,0.009870686,0.03877941,0.014601311,-0.037787303,-0.028751737,-0.028112257,-0.04749105,0.073832765,0.029372005,0.059347954,-0.015296523,0.017496178,-0.10893051,6.663464e-33,0.007826955,0.047710784,0.03187751,-0.019480234,0.027340122,0.052190643,-0.019707587,0.018015776,0.06310215,-0.021199347,-0.078935035,-0.072625525,0.07250252,0.04526469,-0.055718902,-0.0444352,0.0028517852,0.056308232,0.04511789,-0.028725015,-0.088365704,0.028946282,-0.043480944,-0.058214013,0.015611601,0.031641062,0.02882756,0.0030445673,-0.006344202,-0.012571405,-0.04554975,-0.08928351,-0.100002475,-0.020788591,0.04289189,-0.03978994,0.03612602,0.011371152,0.06554651,0.083610415,-0.013733923,0.026434159,-0.040333804,-0.0020575447,-0.0013996521,-0.022966532,-0.0624667,0.08143639,-0.035263088,-0.01773782,0.0016262351,-0.029951336,0.07501442,-0.06602325,-0.09751217,-0.037583604,0.0042235763,-0.030186892,0.028454136,0.032377597,-0.04452348,-0.01721042,-0.01411782,0.05172996,0.0002936643,-0.016521832,-0.1431137,-0.067249656,0.029281288,0.07436729,-0.025920251,-0.011877417,0.12441274,-0.0797231,0.017529204,-0.08313336,-0.05741872,0.030649386,0.01261263,0.08196039,-0.07006602,0.04941784,0.023283884,-0.059832796,-0.06925646,-0.054444287,0.044622198,-0.101195104,0.0026920894,-0.017297734,0.042742558,-0.014948219,-0.07049607,-0.010363075,-0.004306012,-6.51955e-33,0.050730262,-0.0026195492,0.026432285,-0.07997948,-0.054411534,0.04696961,0.043133907,0.044860817,-0.01982622,-0.10853122,0.112305865,-0.0075835846,-0.0039345813,-0.013470694,0.037390113,0.02675322,-0.048745897,0.11562285,0.0411409,-0.018664774,-0.051299904,-0.008328109,-0.0824286,0.1390793,-0.020226074,0.02239319,-0.04987576,0.021822017,0.020251984,0.05310723,-0.04785899,-0.018869825,-0.037042543,-0.016308598,0.028520439,-0.016557354,0.021115817,-0.005391752,-0.030724065,-0.013273187,0.039144807,0.004239458,-0.012174011,0.063410096,0.005113261,0.06527836,0.043363012,-0.057209074,-0.07553749,-0.092962794,0.04845333,0.009763154,0.034203537,0.03572605,0.010921228,-0.009687549,0.019409906,0.0045974017,0.0074258065,0.020931993,0.036520857,-0.049636174,-0.029834216,-0.0001614171,0.050115433,-0.0044339835,0.021162145,0.016097365,0.0074685495,0.03913382,0.023430394,0.06057093,0.019539176,0.01167026,-0.054510206,0.029083755,0.0032233146,-0.052074067,0.0041952915,-0.06033696,0.040281918,-0.016753385,-0.077598445,-0.020451633,-0.05074859,0.03994171,0.08840062,0.171137,-0.007454909,0.03240487,-0.049706057,-0.044310562,-0.09272362,0.09650362,0.04350308,-5.081834e-08,0.038963508,-0.075724244,-0.06297199,-0.0044615143,-0.08217819,0.11451864,-0.064403474,0.039019715,0.020361088,-0.0049992735,0.013104092,0.028878413,-0.030281013,0.019643584,0.0004490668,0.06588714,-0.046344195,0.0035454796,0.012868259,0.001368451,-0.075391494,0.06468476,-0.070946366,-0.029039662,0.02276538,-0.032407403,0.008055664,0.13401288,0.019179888,-0.0681555,0.010914354,0.006169143,-0.030719439,0.004101139,0.0045585143,0.032855853,0.06661098,-0.07493281,0.012687197,-0.024591923,-0.0017147544,-0.0036707153,-0.060895827,-0.032488417,0.022586687,-0.020274084,0.007858896,-0.0084479395,0.028090319,-0.02652178,-0.030177372,0.04643283,0.026212128,-0.07686016,-0.052761823,0.027290205,-0.13912322,-0.056315046,0.005253095,-0.0072581065,0.066238,0.020016663,0.06799734,-0.040176112 +2.1.1.320,"The enzyme catalyses the methylation of one of the terminal guanidino nitrogen atoms in arginine residues within proteins, forming monomethylarginine, followed by the methylation of the second terminal nitrogen atom to form a symmetrical dimethylarginine. The mammalian enzyme is active in both the nucleus and the cytoplasm, and plays a role in the assembly of snRNP core particles by methylating certain small nuclear ribonucleoproteins. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase.",384,1.0,-0.013523448,-0.07400043,-0.13672915,-0.04685442,0.027623735,0.046171937,0.01137698,0.04911253,0.016289579,-0.011074169,0.03391512,0.028187744,-0.07103854,0.03294498,-0.0630902,0.04156781,-0.14758597,-0.02386539,0.07261151,-0.035498165,-0.005651912,0.07271633,-0.07997181,-0.030524073,0.0219698,-0.012196545,-0.012833678,-0.057841513,0.040188882,-0.037957642,0.009155606,-0.00784149,0.02405482,0.022730317,0.11163033,0.059575878,-0.012822348,-0.022790473,0.019752385,-0.014646482,0.089950144,0.019572925,-0.012750275,-0.043616578,-0.026075566,0.055277433,0.06626025,0.021346373,-0.0008276774,0.01676544,0.008578152,-0.06396544,-0.021117082,-0.024013158,0.034725584,0.006124887,-0.08913204,-0.075638756,0.02334364,0.053989694,0.0058655194,-0.017758565,-0.0018680779,-0.09046844,0.119675286,-0.053967874,0.09051604,-0.05816886,0.046086103,-0.030215839,-0.008125823,-0.033283755,-0.103423014,0.05710703,-0.096855514,0.0037856735,0.0010036891,-0.0019695691,0.072882295,-0.04030456,-0.021096846,0.0790074,0.047594,-0.0039740163,0.052831177,0.019521536,-0.05891329,0.08222122,0.014271558,0.02464507,0.014801211,-0.023021309,0.049028594,-0.0125332335,-0.015742004,0.042512055,0.025527118,0.009232546,-0.004577355,-0.0039410633,0.060877793,0.032252803,-0.05663428,-0.08590199,0.023485929,0.0889009,0.013251222,0.035636473,-0.02299239,0.028559174,-0.06077659,0.06515218,0.045530386,0.015049719,0.013474937,0.069465,0.05636082,-0.0031858864,-0.052937005,0.0025035802,-0.055265553,0.064068586,0.02566152,0.07087199,-0.018439498,0.023010613,-0.07099785,6.869493e-33,0.039921775,0.030025166,0.013204979,-0.004751871,-0.0048687537,0.03810548,-0.013723366,0.023115708,0.044841703,-0.0068554524,-0.09442499,-0.13026288,0.09112175,-0.0053708246,-0.06345086,-0.031134594,-0.024489442,0.027295975,0.0385456,-0.04777413,-0.058325805,0.02328531,-0.033039633,0.002578128,-0.004977558,-0.0017139419,0.0065742475,-0.059394617,0.045589965,-0.015839467,-0.066037916,-0.07382022,-0.08363723,0.038891014,0.07889332,-0.053831276,0.06325983,0.014046222,0.033103064,0.11068216,0.038658407,0.027309949,-0.052725267,-0.019622818,0.011793576,0.0037396462,-0.07619933,0.03274152,-0.0042261267,-0.02150292,0.015263184,-0.04460708,0.08713383,-0.041637745,-0.051225964,-0.006321966,0.021145357,-0.027896242,-0.0028948258,-0.01990556,-0.027765162,-0.04151332,0.015977398,0.0040524076,0.004355313,-0.02261289,-0.106503285,-0.10953524,0.031892814,0.05922651,-0.032683484,-0.009851113,0.11199533,-0.059281368,0.025202157,-0.05551467,-0.1409129,0.042400733,0.027632283,0.07021632,-0.05324629,0.09218239,0.0015111418,-0.05707236,-0.0037396469,-0.051423736,0.06154274,-0.09199856,0.016399391,-0.015024391,0.034440596,-0.05387459,-0.03619486,-0.027900895,0.02523991,-5.4602693e-33,0.044222217,-0.030391535,0.0068145436,-0.05649927,-0.05777368,0.039539587,0.03624184,-0.023535084,-0.061770458,-0.058502484,0.09947458,-0.038176693,0.0057854657,-0.02314176,0.0841264,0.009190703,-0.027526999,0.12832683,0.053511385,-0.04507197,-0.027097965,-0.040778086,-0.040812243,0.08910434,0.014474372,0.015844006,-0.06001905,0.0017503331,0.0637658,0.022615902,-0.06376544,-0.023999935,-0.062916644,-0.042923965,0.026563533,0.009546023,0.01660307,0.018139713,-0.07042754,-0.05446812,-0.004488092,0.06483024,0.0046861824,0.11140116,0.021476027,0.04170998,-0.0020999468,-0.04103688,-0.07584785,-0.07330592,0.07266663,-0.031128598,0.026933648,0.06573382,-0.012510363,0.0026966357,0.079116605,0.04383566,0.021595007,0.0066853403,0.011732501,-0.07330009,-0.06624875,-0.011793551,0.05975016,0.032986727,-0.0070321555,0.03230696,-0.0050080526,-0.04541349,0.03602825,0.017936071,0.105950974,0.07748719,0.010970513,-0.057496224,0.026654815,-0.037903007,0.007863197,-0.11665636,-0.01555991,0.0057706726,-0.068282634,0.012931049,-0.031801935,-0.007593044,0.087970816,0.14558409,-0.01863644,-0.005491657,-0.048286144,-0.0040940153,-0.08655933,0.057670467,0.0803264,-4.834034e-08,0.03579108,-0.07330697,-0.06837144,-0.034498315,-0.022285473,0.13767962,-0.030579157,0.047838725,0.046696033,-0.026117973,0.046168063,0.027287912,-0.009172928,0.029817402,0.043485653,0.034231566,-0.03008803,0.01889791,0.0121138515,0.01571772,-0.016111743,0.08794483,-0.08476197,0.0038397124,-0.03968217,0.0014525551,0.015321516,0.13499936,0.026669098,-0.068557754,0.03397219,0.036376793,0.018697705,-0.0007168712,-0.049183518,0.052373637,0.06585367,-0.047227755,0.023510728,-0.012001012,-0.046110593,0.04273983,-0.08711359,-0.048014034,0.005955379,-0.025690664,-0.010642892,0.040729392,0.011734648,0.042211063,-0.01813601,0.0027164964,0.02499025,-0.069870085,-0.05319894,-0.05204409,-0.08045362,-0.08711753,0.027347185,0.018383209,0.046476286,0.008834442,0.093811706,-0.025580749 +2.1.1.321,"Type III protein arginine methyltransferases catalyse the single methylation of one of the terminal nitrogen atoms of the guanidino group in an L-arginine residue within a protein. Unlike type I and type II protein arginine methyltransferases, which also catalyse this reaction, type III enzymes do not methylate the substrate any further. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase.",384,0.99999994,-0.029191751,-0.07134437,-0.10990441,-0.053371314,0.055742092,0.013508518,0.050240137,0.012860552,0.030437706,-0.061054885,0.026902536,0.009791422,-0.073037475,0.003681404,-0.0148204435,0.039129704,-0.11033389,-0.044379603,0.06812325,-0.0314157,0.06177803,0.052524883,-0.06289393,-0.031647388,0.004014904,-0.029565113,-0.059350085,-0.038220182,0.083817706,-0.04727369,-0.040328372,0.005184365,-0.018390702,-0.013436675,0.10687095,0.054422397,-0.029258966,-0.03692344,0.029538289,-0.019461226,0.09284865,0.05669439,0.036407076,-0.0829947,-0.04112517,0.026494203,0.028282732,0.003987967,-0.01268213,-0.04378829,0.01053906,-0.038041875,0.0027558128,0.0132759735,0.023039728,-0.027792992,-0.11961987,-0.025169123,0.003995782,0.043706276,-0.0056348545,0.050240137,0.010241976,-0.091523275,0.07556371,-0.027422281,0.07166443,-0.062417246,0.068637736,0.004074468,-0.07353282,-0.05626461,-0.109420255,0.040330287,-0.040753238,0.031178856,0.01773254,0.023145432,0.03038911,-0.07053744,-0.027515288,0.052055445,0.06768536,0.01888443,0.02412157,-0.05446304,-0.07547876,0.06820647,0.03424333,0.062447414,0.022403922,-0.019188315,0.07697763,0.039051637,0.0072707864,0.026852349,0.020251455,0.0068599815,0.029945737,0.028524194,0.061967846,0.050335698,-0.065582566,-0.063489266,0.054004397,0.05823853,0.015065694,0.07022217,-0.037064295,0.014971315,-0.05505216,0.029244006,0.054069713,-0.014651605,-0.061719213,0.07227512,0.035247475,-0.030828185,-0.050633077,-0.010493566,-0.006929957,0.020772533,0.060181268,-0.0052644457,-0.041360855,0.0045750854,-0.079900935,5.643705e-33,-0.0038874028,0.0363618,0.0007834622,-0.018418977,0.00026328632,0.027616587,-0.051861655,0.03411388,0.053610608,-0.030090665,-0.08972906,-0.12276846,0.035975825,0.05035266,-0.022942325,0.017923452,0.0034500624,-0.00033304238,-3.0724983e-05,-0.032823496,-0.029479623,0.024608383,-0.030433789,-0.033904683,0.02619875,0.048723,0.043804258,-0.048102222,-0.0015771437,-0.0024612437,-0.014553018,-0.13429278,-0.06867192,-0.0064055333,0.057888456,-0.010600616,0.09022009,-0.013142627,0.0414144,0.10846901,0.017935459,0.048404325,-0.028948357,-0.02019784,0.015379614,0.0011580864,-0.012704657,0.07023599,-0.0032749197,-0.007624929,0.021323305,-0.034631416,0.06428944,-0.050768282,-0.04602841,-0.034296088,0.031531,0.0076323044,0.030187843,0.003971224,-0.019857131,-0.05487876,0.052178554,0.0132810045,-0.06118324,-0.026921315,-0.105439015,-0.075208955,0.044212557,0.05524787,-0.047961187,-0.040808253,0.12056681,-0.026776483,0.061108086,-0.09725497,-0.13923655,-0.011076563,0.081446595,0.082457446,-0.057253063,0.04669854,0.044525992,-0.05324115,-0.03783284,-0.06905095,0.028394237,-0.080403164,0.07803358,-0.021865638,-0.009348187,-0.0060666655,-0.019193312,-0.013027349,0.0065512615,-5.1875572e-33,0.06782106,0.0013997135,-0.0025039932,-0.14697978,-0.06668468,0.023567244,0.023729555,0.011672772,-0.03726574,-0.0534671,0.10616001,-0.020120941,0.04706165,-0.014864268,0.066886455,-0.027900644,-0.06211956,0.06341083,0.031979233,-0.025923269,0.01964857,-0.066299304,-0.032490946,0.112092905,-0.055923827,0.07278143,-0.06649135,0.05117403,0.047808565,0.050570935,-0.064833805,-0.046158724,-0.035944637,-0.032659013,0.016321575,0.01840846,0.056073923,-0.00092650787,-0.11033147,-0.024093108,0.024920896,0.032421827,0.015944092,0.06053054,0.018370964,0.077517316,0.031193301,-0.047785588,-0.037960403,-0.0587396,0.0773207,-0.043252923,0.03784655,0.056577884,-0.015984675,-0.042030733,0.029275114,0.015240529,-0.08325504,0.060792085,-0.00945619,-0.08636892,-0.0056740744,0.006138414,0.06786091,0.002059362,-0.008609464,0.039484173,0.017048636,-0.014809111,0.04949592,0.022615097,0.03623625,0.033759266,0.009165992,-0.053337246,-0.007890744,0.0062369644,0.021046918,-0.14202997,0.016415687,0.002947666,-0.018617555,0.025122458,-0.041257184,0.021825926,0.04467773,0.13175479,-0.036501344,-0.005096814,-0.041991115,-0.007582972,-0.08249563,0.10513334,0.06615271,-4.087312e-08,0.022775298,-0.06270515,-0.046074774,-0.016566103,-0.070348725,0.13570742,-0.11546323,0.052650955,0.032867786,-0.012098819,0.010461958,0.0010354109,0.018290773,0.0058909394,0.031222988,0.053201128,-0.029533865,0.02604882,-0.00075690245,0.02093019,-0.04619814,0.08233762,-0.023512572,-0.04051368,-0.0058248593,0.00093491736,-0.021479866,0.10880267,-0.011918253,-0.010465407,0.007703029,0.07933378,-0.018613776,0.032598857,-0.00016698429,0.036162056,0.051043347,-0.09014809,6.655288e-06,-0.021232264,-0.03864561,0.070104785,-0.100504585,-0.041828856,0.07240738,-0.036764413,-0.010799328,0.030275555,-0.011074513,0.038476147,0.01983513,-0.0028749008,0.027839312,-0.036944356,-0.055506606,-0.051519,-0.11305094,-0.04937411,0.027284654,0.0018549598,0.079030104,-0.033530425,0.11064961,-0.021700678 +2.1.1.322,"This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, and EC 2.1.1.321, type III protein arginine methyltransferase.",384,1.0,0.011141268,-0.048764665,-0.1367113,-0.044825953,0.03602875,0.035842955,0.050692633,0.021536026,0.02180962,-0.049602315,0.0017482938,-0.014435833,-0.07221346,-0.011341236,-0.092288144,0.025795262,-0.100594714,-0.073770694,0.06772154,-0.035385683,0.042107727,0.11852039,-0.059761703,-0.052191146,0.018775169,-0.041627076,0.026733823,-0.0062120655,0.06929026,-0.10056273,0.013690304,0.01742905,0.02128314,0.015159669,0.071710534,0.09002458,0.023148922,-0.03546109,0.046997536,-0.018374043,0.06945115,0.0241731,0.011634896,-0.040000856,-0.03153884,0.06496023,0.05680311,0.02871427,0.027320959,-0.0073018405,-0.00018730633,-0.06359586,0.0033873022,-0.013256692,0.012853841,-0.0050475365,-0.05879812,-0.10016987,0.01132024,0.035633735,0.011119233,0.014230359,-0.021424012,-0.035971634,0.02508731,-0.047186323,0.098589614,-0.05543476,0.05443269,-0.01696564,-0.0760343,-0.042344857,-0.11786659,0.07208625,-0.040160265,-0.00028475586,0.02657127,-0.08429418,0.10138818,-0.07343716,-0.009921968,0.026820287,0.088238254,0.050039534,0.020417953,-0.03830283,-0.027858637,0.088944204,0.07789349,-0.0014112783,0.03752773,0.008905133,0.040475454,-0.015606764,-0.029813498,0.04184175,-0.011423041,0.050674457,-0.001306478,0.02351618,0.07983872,0.07810973,-0.047437284,-0.045530256,0.04258124,0.07104743,0.034802586,0.104173385,-0.01354383,-0.0033321225,-0.0671648,0.037073683,0.0077162706,-0.02336064,0.0028550555,0.029980084,0.06320929,-0.039548364,-0.05166212,-0.023100952,-0.025504818,0.075974084,0.055348318,0.042887222,-0.054522127,-0.001663824,-0.10588167,4.2450223e-33,0.020648265,0.029898548,0.040960703,-0.050571032,-0.014040743,0.009615781,-0.034504212,-0.0153631205,0.010852274,-0.031276856,-0.11170352,-0.103101104,0.04482325,0.048198666,0.0096830465,-0.014849374,-0.0012004499,0.02783745,0.03063688,-0.021331657,-0.061133087,0.06828171,-0.05003353,0.012672556,0.05390183,0.05110799,0.057849873,0.0025595096,0.0068364707,-0.026693642,-0.0216074,-0.065649375,-0.067514926,0.026480742,0.049119096,-0.023518113,0.04156847,0.05914593,0.030874178,0.06820225,0.069771,0.036487605,-0.009405607,-0.018335294,0.004506228,-0.024025748,-0.025307082,0.050682534,0.016466143,0.034936458,0.025024412,-0.040548887,0.121482775,-0.07278278,-0.023156732,0.026397737,-0.01922789,0.05437606,0.0344594,-0.008377452,-0.03479203,-0.0074492856,0.02391399,0.0972089,-0.023254065,-0.019080982,-0.06244237,-0.12319284,0.009373632,0.051857177,-0.07218714,-0.019781513,0.13398218,-0.053437844,0.016867084,-0.07636181,-0.1486607,-0.040038716,-0.0010826217,0.069833234,-0.06424567,-0.004556877,0.028405476,-0.07647068,-0.05395773,-0.057717916,0.04980359,-0.058636848,0.009025977,-0.031218546,0.011270271,-0.008380733,-0.06916393,0.027305877,0.010658296,-4.0435907e-33,0.087738596,-0.029779332,0.050179746,-0.077609904,-0.07702328,0.05289463,0.06306207,0.0147326905,-0.0662205,-0.065254286,0.097370096,-0.026026538,0.042125396,-0.033070162,0.054601435,-0.019526992,-0.025529353,0.08060966,0.053916957,0.0055752015,-0.05461383,0.014230583,-0.03478506,0.062338065,-0.02412569,0.030758161,-0.019060068,0.014003172,0.03393833,-0.01848545,-0.0492976,-0.015864303,0.02640528,-0.03141871,-0.018431386,0.037088018,0.055808466,-0.010325305,-0.08550181,-0.040003356,0.010868595,0.06037022,-0.038330726,0.084766574,-0.00081380794,0.06282818,0.030929005,-0.04782959,-0.06372485,-0.114775375,0.031620074,-0.06536687,0.05547739,0.05683933,0.0049131564,-0.027562542,0.021219688,0.06187093,0.0057669976,0.027200505,0.010715042,-0.048688516,-0.03255539,-0.002117287,0.08590089,0.021294251,-0.05483727,-0.0038684641,-0.039600216,-0.031925227,0.06667442,0.041976135,0.009828669,0.08919198,0.0087149525,-0.07579035,-0.018639931,-0.03309198,-0.035024296,-0.075118124,0.02031161,-0.036158264,-0.04902525,0.042395968,-0.061628535,-0.024255376,0.048611544,0.115613766,-0.030360647,0.027998202,-0.030126905,0.010227552,-0.101804756,0.07497886,0.035426863,-4.0262204e-08,0.06956882,-0.045966204,-0.018662317,-0.108113244,-0.042423327,0.1089069,-0.026702281,0.024810148,0.012450639,-3.4350644e-05,0.017166609,0.03405827,0.015644563,0.041874614,0.014753842,0.0071296147,-0.061607763,0.027352871,0.02070258,0.023312237,-0.0052305544,0.069692776,-0.031419918,-0.021715619,0.0011713848,-0.020222157,0.0055549378,0.099136546,0.029378721,-0.06834751,-0.016514542,0.06984023,0.015472746,-0.03027899,-0.04189899,0.0936576,0.020357143,-0.070705935,0.02417523,0.05189071,-0.028512463,0.018465532,-0.09619012,-0.061959773,-0.015231595,-0.034321588,0.017727697,0.020819573,0.026458366,-0.028732883,0.00214495,-0.00171855,0.021744791,-0.08660699,-0.07676172,-0.01213173,-0.12018049,-0.07256579,0.06392146,-0.004159573,0.09161106,-0.0151940705,0.04869699,-0.05516069 +2.3.1.251,Isolated from the bacteria Escherichia coli and Salmonella typhimurium. The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position. There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds. The enzyme also acts on Kdo-(2->4)-Kdo-(2->6)-lipid IVA.,384,1.0,-0.03236095,-0.10682185,-0.08427328,-0.044924136,0.0034391126,0.047502514,-0.052445844,0.026642062,0.05308451,0.015041937,0.04522162,-0.036619075,-0.07250036,0.09472132,0.014371171,0.027628444,-0.020649156,0.0019103762,0.016341778,-0.00018493086,0.07496384,0.0076269917,0.023753239,0.009094892,-0.057385996,0.065154836,0.07785505,-0.012524063,-0.0067241313,-0.08686977,-0.058034886,-0.0673265,0.074883774,-0.10193485,0.077041194,0.03868762,0.011571131,0.003437448,0.07576136,0.030593608,0.024518354,-0.004541125,0.03264663,-0.03542976,0.012393963,-0.023438253,-0.032945607,0.053166527,0.10998791,-0.032960307,-0.012380137,-0.10202899,-0.0137968995,0.05560936,-0.026028646,0.07322696,-0.11854797,-0.015949454,-0.0001467272,0.009453841,0.077143155,0.010996239,0.0650031,0.046096902,-0.014788773,-0.061666764,0.0282643,-0.03159314,0.07490981,-0.023220038,-0.045414016,-0.036030978,0.018269008,0.08064836,0.010722816,0.06026091,0.04696431,-0.035546593,0.06648404,-0.110826634,0.038040586,-0.043004613,-0.03110136,0.113930695,0.014167928,0.0026174786,-0.054442983,0.015541003,0.07820976,0.063614145,0.015081857,-0.037324846,0.034076452,-0.09299341,-0.045986526,-0.0065152603,-0.009633182,0.020066373,-0.008413088,0.0070815915,-0.006868071,-0.006330573,0.030751174,-0.064309984,-0.021808106,0.029205654,-0.0067689414,-0.102600046,-0.01362746,-0.0069467267,-0.00049337815,0.060663592,0.044813577,-0.06027181,0.0024847207,-0.032218847,0.06457713,-0.05582567,0.0014757169,0.0055796034,-0.009068461,-0.14230575,0.022897461,0.017090932,-0.015986808,0.07461268,-0.07439566,3.7826784e-33,0.06702074,0.008007814,0.017923824,-0.05603036,0.023196494,-0.09116735,0.00090244255,-0.015857475,-0.10625766,-0.017637417,-0.0486826,-0.096955545,0.04964953,0.0342068,0.01820155,0.035854694,0.006852617,0.048989847,0.072668426,-0.018677527,0.033869304,0.0495444,-0.006784853,0.021528715,0.05210691,0.008754384,-0.028176814,-0.0647776,0.028308995,0.018160177,0.06270511,-0.0835599,-0.093983024,0.05013526,0.03811845,0.05377747,-0.06508053,-0.030575866,-0.01189707,0.018993953,-0.044725146,0.022707717,-0.04379463,-0.015584043,0.009126515,-0.046626695,-0.08811369,0.0637962,0.08266717,0.0020601982,-0.010807266,-0.050600305,0.063079365,0.005531219,-0.005075251,0.016018525,0.035643138,-0.015307903,0.06716518,-0.026952561,-0.011767964,0.058710326,-0.09890355,0.01665572,0.072367094,0.03225563,-0.057387665,-0.078079335,-0.05983894,0.039708152,0.0016973149,0.009843941,-0.033420455,0.017128501,0.008681642,-0.055667426,-0.0012352586,-0.017345263,0.016170297,0.014910498,0.054548457,-0.02700021,0.055900417,0.028608236,-0.07977481,0.06741101,-0.034311425,0.017866686,-0.00350602,0.023267651,-0.0064561265,-0.062349208,-0.045419883,0.046751253,-0.032360625,-4.9825973e-33,0.023207283,-0.046734683,0.043053914,-0.0608296,-0.08435469,0.12977843,0.0055788276,0.063100725,0.07271939,0.0047459602,0.07976401,-0.015764832,0.0270651,-0.008228834,-0.0026074296,0.043839157,-0.060221422,0.05764061,0.011421631,-0.05640644,-0.044902433,0.041078154,-0.014410625,0.09022409,0.037086733,-0.025151081,-0.06364335,0.12074891,-0.09771227,0.045779083,-0.012804351,-0.024789719,-0.042464443,-0.079795256,-0.056830358,0.027166622,-0.1093492,-0.012477559,0.009337231,0.05140524,-0.028908359,0.038479406,0.114368044,0.03290022,-0.010628121,0.04948163,-0.062401313,0.050977524,-0.011348375,-0.0122436,-0.04547749,0.017651021,-0.014958136,0.00997289,0.012744433,0.10415232,0.03576618,0.032713417,-0.054460824,-0.091390856,-0.040101025,-0.12204545,-0.029427674,0.028075526,0.076390475,0.09019199,-0.02642668,0.027562752,-0.027932003,-0.07822713,-0.020369092,0.019372806,0.07542812,0.04163799,0.0006964233,-0.041255936,-0.0760279,-0.0747256,0.05333182,0.008977538,0.05580719,-0.007724465,0.00311361,-0.08298568,0.05952965,0.026782867,0.017993469,0.055512644,0.03690676,0.031652097,-0.0037544619,-0.002196445,-0.10238365,-0.0069279177,0.06268244,-4.18717e-08,0.12236219,-0.07206671,0.02123345,-0.06519665,-0.040084116,-0.023136789,0.0007717031,-0.0047890954,0.05335261,-0.031706274,-0.01565631,0.080716416,0.008510586,0.031611472,0.034368858,0.02958316,-0.033243496,0.037576042,-0.060024254,-0.09062832,-0.019035399,0.003388879,-0.0276735,-0.004965313,0.049739618,0.0069033504,0.04112529,0.0018699878,-0.022067323,-0.009364543,-0.020667724,-0.00016091739,-0.08508943,0.003726696,-0.06281752,0.053756848,-0.08036428,-0.014006085,-0.07148077,0.09409159,0.008179167,-0.03934413,-0.07080904,0.02779458,-0.03553964,0.04586903,-0.012343198,0.029830284,-0.029049685,-0.053560253,-0.021871457,-0.049294088,-0.01075792,-0.044384897,-0.11528796,-0.0002322594,-0.005379542,-0.082572706,-0.036436692,-0.026201189,-0.0011471302,0.007733402,0.15970607,0.011433481 +2.4.1.335,"The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain. ",384,1.0,-0.06787588,-0.018788237,-0.08857529,-0.017499087,0.0397817,-0.030397616,-0.09019916,0.0904611,0.09995381,-0.09720305,-0.023449551,-0.05445493,-0.087525144,0.06496308,-0.07143919,0.016845772,0.05656117,0.026209133,0.006165065,-0.034925837,0.050862987,0.0915244,-0.00834184,-0.0014347003,-0.014727182,-0.036454298,-0.011133944,-0.015173444,0.018789755,-0.01355043,-0.011165714,-0.028347954,0.07399925,-0.023346554,0.00203695,0.12703437,-0.031192053,-0.05265096,-0.010098504,-0.010129611,0.03511784,0.0005861375,0.07139648,-0.010973539,-0.05321114,-0.010494077,-0.00044161937,0.039148312,-0.0084315175,0.020288115,-0.0541881,-0.09193746,-0.039820295,-0.005379716,0.05587453,0.11477333,-0.04621531,-0.029774476,0.011999868,0.021282772,0.01066739,0.07815525,-0.019647408,0.07222463,-0.05566584,-0.04183945,0.032595836,-0.09284485,0.021895865,-0.06296586,-0.045464814,-0.034095973,0.060964856,-0.05137011,-0.058560926,0.013353421,-0.0035097268,0.00042004776,0.08129771,-0.08804666,0.06991522,0.020261304,-0.019806387,0.06218097,0.006067318,0.026809763,0.010349757,-0.013835823,0.031578876,-0.08461121,0.0608608,0.0146656595,-0.03310528,-0.09343181,-0.09932341,0.017877368,0.07703602,0.08436897,0.021486076,0.05502494,-0.01150329,0.019688515,-0.019800184,-0.043761395,-0.1115338,-0.062423166,0.020395912,0.08420791,0.03879614,0.06912255,0.0680933,0.025035309,0.06752596,0.02746855,0.022351597,-0.022716722,0.022255268,-0.100336134,-0.0498146,0.030624729,-0.007716329,-0.106834985,0.054783404,0.016770242,0.0058065522,0.03129142,0.011293887,1.3312353e-34,0.11298102,-0.029212566,0.0010802217,-0.019070245,0.040305167,-0.014656818,-0.037825406,0.002089176,-0.07968792,-0.0018265994,-0.017018503,0.015777053,0.023422139,0.07311627,0.028975062,0.02913932,0.036730114,0.005749056,0.047258712,0.02501084,0.04741713,0.06806051,0.0151788,0.029012455,0.036447402,0.039696917,0.00046470715,-0.03524865,-0.027640514,-0.0083216,0.04975558,-0.10530977,-0.11699456,0.07188219,0.015205626,0.077477515,-0.0794995,-0.020770067,-0.047253117,-0.039355118,0.021888377,0.05062667,-0.042951614,-0.05204809,0.0841315,-0.006633054,-0.017790338,0.05457606,-0.0014131832,0.07983456,0.040318903,-0.014634739,0.031412423,0.0021961238,-0.07282478,0.062336713,-0.02086696,0.01618622,0.04106439,0.0925732,-0.08279632,0.048242062,-0.054003246,0.046179045,0.03970647,0.05190495,-0.04463015,-0.036158066,0.02324344,0.053691104,-0.011718448,-0.033467922,0.009267818,0.088526435,-0.0604466,-0.06997487,-0.02491446,0.022935197,0.026472952,-0.026069889,0.028439058,-0.058076866,0.028292859,-0.01737443,-0.084537394,0.023368096,-0.022047395,0.0037797277,-0.013699119,0.001166913,0.032843906,-0.08499364,-0.048956644,0.059968878,-0.014448609,-2.4132668e-33,0.062251203,-0.11577348,0.027804278,-0.031738274,-0.04414283,0.071941376,-0.025579475,-0.021929255,-0.00761952,-0.07893043,0.090751044,0.040412303,0.02159706,-0.03086173,0.046253797,-0.029688198,-0.05037271,0.047550865,-0.003479548,0.02599793,0.044480283,0.014429259,-0.046097636,-0.03624461,0.052294333,0.003506998,0.009613536,0.041723147,-0.028843043,0.028616773,0.0006267228,0.067493096,-0.015344833,-0.078557305,-0.041432932,0.020508803,-0.097411335,0.011822617,0.0012841292,-0.019508025,-0.013868828,0.088556826,0.05398032,-0.021392338,-0.0037815527,0.1239917,-0.12773742,-0.038681082,0.06419792,-0.06599781,-0.003940486,-0.08721312,-0.027328977,-0.032538947,-0.029896304,0.07258534,-0.0022712406,0.004992394,-0.015399181,-0.073870644,-0.05623267,-0.039896425,0.030771421,0.044608593,0.017119868,0.03899739,-0.006556855,0.013845002,-0.011784778,-0.030811217,0.018059837,0.02951982,0.04939675,0.04473101,-0.052904524,-0.0669793,-0.043857962,-0.015554728,0.010674634,-0.008219366,0.047743388,0.008160812,0.026341727,-0.041200515,-9.096234e-05,-0.078587055,0.10525642,0.0809146,0.017127642,0.05284728,-0.037912454,0.033947103,-0.082842074,-0.022165783,0.09711552,-4.1167237e-08,0.050666686,-0.011344774,0.047325402,-0.05014503,-0.068699665,0.017728047,0.035050068,0.040574133,0.044394344,-0.026865195,-0.0016739492,0.09310168,-0.06461202,-0.037788197,-0.017104998,0.08368704,-0.082217626,-0.07540499,-0.04145925,0.07516699,-0.01232492,-0.024759213,0.010626185,0.0036701334,0.034005936,-0.056772374,0.008235733,0.07267282,-0.044725195,-0.05521908,-0.06849748,0.046720497,0.014236401,0.03955509,-0.038121037,0.00881438,-0.04089678,-0.056248948,-0.04273671,0.021526208,-0.00721752,-0.05268,-0.04272386,-0.014625966,-0.014502593,-0.031540357,-0.037210565,0.03976986,-0.007388214,0.07820504,-0.001355537,-0.0004148287,-0.01856416,-0.11639419,-0.089812316,-0.03725391,0.0039379178,-0.03270793,-0.06921395,-0.014214542,0.10212059,-0.0684237,0.18152635,-0.041810997 +2.4.1.336,"The enzymes from cyanobacteria are involved in the biosynthesis of galactolipids found in their photosynthetic membranes. The enzyme belongs to the GT2 family of configuration-inverting glycosyltranferases [2]. cf. EC 2.4.1.337, 1,2-diacylglycerol 3-alpha-glucosyltransferase.",384,1.0,-0.11852079,-0.028760362,-0.13316666,0.033910867,-0.033780243,-0.01691328,-0.06582002,0.037999578,0.01990273,-0.040530674,0.056243744,-0.036999755,-0.08588154,0.005473551,-0.011490468,0.049980085,-0.07313966,0.009353728,-0.020933187,0.021116028,0.071477346,-0.0033693765,-0.03337839,0.035618536,0.05370181,-0.01638526,-0.035075996,-0.039573275,-0.026248233,-0.0139479125,-0.04142207,-0.09011358,0.066572,-0.046480007,0.12167176,0.025707528,0.0062797205,-0.055600245,0.05705751,-0.0074055106,0.058730632,-0.0038197024,-0.0147381965,0.016821608,-0.021912526,0.011329865,0.012835007,0.0329011,0.0100090895,-0.031667955,-0.025547676,-0.032821205,-0.09179308,-0.0061735823,0.04732907,0.04442596,-0.07297043,-0.06367506,0.056844633,0.024832899,0.07742594,0.019879086,-0.071369074,0.028193977,-0.08132082,-0.09698922,0.026281053,-0.056961853,0.08031051,-0.06885188,-0.086430475,-0.074754804,-0.06969347,-0.017847948,-0.04300657,0.07128166,0.037797786,0.0057328353,0.009590721,-0.056545503,0.11618164,-0.02318839,0.059203055,0.07326225,0.016302945,-0.07970276,0.013428448,0.04677983,-0.022737784,0.04762365,0.034399223,-0.041755572,0.035129372,-0.031644482,-0.062045082,0.04893,0.086837694,-0.046697687,0.07761408,-0.009310628,0.029042948,-0.0016451112,0.083255656,-0.045554094,-0.007235135,0.0276742,-0.016304655,0.08342754,0.022109238,-0.016411005,0.0085815815,0.028588817,0.044142812,-0.013446401,-0.053149022,0.062157486,0.0023617914,-0.0076991837,-0.043726172,0.084003516,-0.0029327602,-0.0331406,0.019788079,0.0036113036,-0.016798044,0.06856493,-0.057239946,2.2389889e-33,0.09994761,0.04812476,0.040389806,-0.04322477,0.011804843,-0.0073324116,-0.09008567,-0.050576974,-0.015819818,-0.040336054,-0.0943811,-0.06448272,8.213474e-05,0.05105204,-0.07346355,0.0940022,-0.036284037,-0.040164746,0.056027517,0.038060036,-0.03925367,0.049550124,-0.014183604,-0.06253739,0.05531802,0.058415264,-0.053081747,-0.019872524,0.050966643,-0.0029185095,0.029573118,-0.13737608,-0.04361446,0.04716882,0.12761107,0.019616231,0.024035372,-0.118705146,0.040845778,0.039901786,-0.07918682,0.014339146,-0.005250486,-0.032446783,0.024092862,0.04987615,-0.031054486,0.021107273,0.050086807,0.0008459105,0.03702805,-0.024023896,0.013114234,0.07068306,0.0042583863,0.04098453,0.0019235299,0.07010266,0.021882748,0.032524414,0.038909607,0.07013884,-0.019499129,0.01233097,0.07042646,0.019214956,-0.08478943,0.029018575,-0.06602615,0.04431,-0.038655512,-0.07141872,0.074128374,0.009492358,0.06587868,-0.019956214,0.03803739,0.012655443,-0.018437797,0.0115816835,-0.030845908,0.05671195,0.038427863,-0.06724614,-0.05780684,0.009117966,-0.049832553,-0.074354954,-0.0036223265,0.061161,-0.08482811,-0.01185018,-0.038266256,0.034860663,-0.05720549,-3.890727e-33,0.083011806,-0.06490395,0.06458769,-0.10576797,0.00055314606,0.07642555,-0.051606253,-0.03302924,0.04731227,0.02877831,0.05502432,0.030813422,0.04163285,-0.006065404,0.01153795,-0.014346609,0.020719549,0.08754073,-0.099247545,-0.034743324,0.020354806,0.05220828,0.0068684174,0.059284925,-0.007045083,-0.04382566,-0.028447907,0.048762385,0.019068873,0.035695955,-0.014099145,0.017514462,-0.03366141,-0.07861315,-0.020561388,0.014684302,-0.021974979,0.028679624,-0.010572389,0.051972173,0.0054045143,0.017956296,0.03308104,0.019354222,0.073138624,0.049118787,-0.02920964,-0.0014514164,-0.020861939,-0.04462837,-0.03351553,-0.0006477978,-0.049395904,0.13084887,0.021792823,0.04622853,0.098668545,0.038747773,0.045947056,-0.03393519,-0.03660611,-0.11749457,0.028507825,-0.08500911,0.061968442,0.0716296,-0.00634174,0.036671914,0.013407032,0.04459201,0.026739582,-0.0153531935,-0.025021082,0.030845521,-0.026493467,0.04852204,-0.07738637,-0.13662355,-0.015805632,-0.057163935,0.094186224,0.011404297,0.05863102,-0.022820381,-0.013238103,-0.051008355,0.07381328,0.09363316,-0.010448628,-0.009298376,-0.016032618,-0.008712671,-0.026316324,0.05127908,0.018423654,-3.5408267e-08,0.048618812,-0.027321076,0.07490044,-0.06051972,-0.054531697,0.07479161,0.00066009397,0.06429787,0.014885615,-0.046991162,-0.011447656,0.049018145,0.013512084,-0.08239901,0.012778527,0.08860225,0.011073727,-0.019191977,0.008659849,0.020840613,-0.061994463,-0.028315512,-0.07259035,0.036303993,-0.039274845,-0.115050726,0.043925453,0.053149346,-0.020021545,-0.026184423,0.06735441,0.03660081,0.007790451,-9.6846605e-05,-0.095420204,-0.03653657,-0.036149237,-0.075958036,-0.009079181,0.012522403,-0.030481556,-0.008569638,-0.034828197,0.013020088,-0.057060663,0.0076133856,0.023566382,0.054671746,-0.05432787,0.035176136,-0.03152038,-0.028715441,-0.056746695,-0.058576602,-0.052696526,-0.056508835,0.010651647,-0.0012982913,-0.060271207,0.0069685145,-0.042432982,-0.000653408,0.16464181,-0.025491305 +2.4.1.337,"The enzyme from the bacterium Acholeplasma laidlawii, which lacks a cell wall, produces the major non-bilayer lipid in the organism. The enzyme from the bacterium Agrobacterium tumefaciens acts under phosphate deprivation, generating glycolipids as surrogates for phospholipids. The enzyme belongs to the GT4 family of configuration-retaining glycosyltransferases. Many diacylglycerols with long-chain acyl groups can act as acceptors. cf. EC 2.4.1.336, monoglucosyldiacylglycerol synthase.",384,1.0,-0.115797915,-0.021914497,-0.12194461,0.031693038,-0.086807564,0.011673786,-0.09051872,0.021614928,0.03336006,-0.0316196,0.020555202,-0.0387031,-0.06356007,-0.01577158,-0.02458687,0.048490148,-0.05128019,-0.007964364,-0.06499652,-0.10878898,0.057300437,0.05184283,-0.025865238,-0.018842112,-0.010288424,-0.07589043,0.01966998,-0.056771472,-0.014737566,-0.058944903,-0.025134617,-0.057732444,0.043317497,-0.047390033,0.11005456,0.047320534,-0.01697635,0.05162882,0.070828706,0.0040815007,0.047720723,-0.03411956,-0.0012258673,0.020271631,-0.012324655,-0.01776077,-0.021194426,0.066878855,0.084557414,0.024042087,-0.054405503,-0.02246085,-0.058751944,0.023344856,-0.014128573,0.034452755,-0.071638346,-0.04400577,-0.021973174,0.03974263,0.06532646,-0.043711647,0.027259873,0.041947473,-0.07706584,-0.099382855,0.07380535,-0.07655468,0.028431669,0.03782266,-0.039342403,-0.038301058,-0.020019887,0.0063693966,0.012242571,0.044757873,-0.025532499,-0.030002443,0.06622821,-0.032705463,0.06508707,-0.00887227,0.021992872,0.07476909,-0.02590175,-0.10033995,0.052890588,-0.005673904,0.003840073,0.048863843,-0.014281569,-0.024998596,0.04212918,-0.015352887,-0.012034773,-0.021694584,0.05812351,-0.06537456,0.026448244,-0.04166567,0.003638021,-0.0007257341,0.034652226,-0.024223702,-0.05857093,0.012066471,-0.0052447715,0.026268858,-0.004271026,0.047369044,0.033383757,0.02773082,0.09628188,0.002508483,-0.04483079,-0.0038649398,-0.02795831,-0.065095924,-0.03755557,0.0062754815,-0.07231232,-0.031907003,0.04334986,-0.0021332116,0.0020905472,0.09260188,-0.0843402,4.1158704e-33,0.08664912,0.039349448,-0.024382686,-0.043343503,-0.003281425,-0.027374817,-0.06972475,-0.0014194603,-0.10468095,0.025380211,-0.030885454,-0.09990579,0.00791481,0.11344915,-0.016762765,0.046945903,0.0563332,0.025666937,0.068960205,0.014824192,-0.043373536,0.04449882,0.036080956,-0.034099776,0.07335418,0.09361241,-0.01885083,-0.042878725,0.0128260385,0.021068955,0.034827508,-0.09309624,-0.02848371,-0.01708042,0.10055142,0.062551424,0.008686195,-0.02491368,-0.02600142,0.02424017,-0.028143978,0.024429027,0.0036159148,-0.05726111,0.01949185,-0.045884978,-0.102005996,0.053235777,0.043041114,0.056795344,-0.024077784,0.031762805,0.08264449,0.061484564,-0.0076422556,-0.042603668,-0.055098496,0.044280544,0.01925059,-0.007121147,0.014614961,0.15500662,-0.086776875,0.02156393,-0.022361517,0.019494226,-0.08200457,-0.04718167,-0.049090743,0.059799097,0.04941546,-0.013284995,0.0047594584,0.07294239,0.044927947,-0.069744974,0.007960999,0.035397835,-0.016674744,-0.013577344,0.009914265,0.04233244,0.056171045,-0.08683767,-0.07163686,-0.045376983,-0.047492385,-0.020843552,0.016566651,0.011788567,-0.049726218,-0.030487146,-0.04334348,0.06690614,-0.018828934,-4.9826072e-33,0.06411648,-0.048286337,0.07191156,-0.07070808,-0.0054477695,0.07645377,-0.00974165,0.037008453,0.05601548,0.02748209,0.044518232,0.09415176,0.065369256,-0.029158114,0.038786575,-0.012395296,-0.012600603,0.0033747642,-0.051015355,-0.06465383,-0.009898027,0.050229877,-0.0024819141,0.082438424,0.034288436,0.008552162,-0.06502948,0.054021772,-0.07132411,0.058328316,-0.0043436927,0.018000185,-0.09224746,-0.07607783,-0.08262761,-0.0016999058,-0.07390302,0.015548292,-0.04982037,0.039035965,0.0036497125,0.060572337,0.05146645,0.046678927,0.056360554,0.025668433,-0.017457627,0.04197463,-0.014242599,-0.05817623,-0.013265262,0.036972605,0.032860376,0.06719654,0.08741136,0.09264182,0.02770016,0.03463879,-0.044716623,-0.08669993,-0.031998303,-0.14213671,0.06022478,-0.01287971,0.0912951,0.11118103,0.008212505,0.027830308,-0.011471299,0.027332768,0.0005121793,0.056102846,-0.051601656,0.017096473,0.03250733,0.08721588,-0.0798612,-0.070539325,-0.0052140635,0.020849565,0.025425095,-0.007957428,0.06177837,-0.072009586,0.07423024,-0.034327623,-0.009971654,0.04226755,-0.030897371,0.08835632,-0.002160142,-0.05097547,-0.05339853,0.0055732355,0.041045543,-4.0947942e-08,0.07337632,-0.02033408,0.038829807,-0.09303469,-0.06912652,5.5570712e-05,0.02405417,-0.0004979462,0.06823924,-0.057985146,-0.08130781,0.06179776,0.016885886,0.0051316586,0.035557717,0.059052397,-0.047123898,0.034508146,-0.03485169,-0.024107866,-0.050432954,-0.02036925,-0.12318837,0.120758936,-0.019434871,-0.05177135,0.06648172,-0.046873264,-0.056699645,0.043588642,-0.012284156,0.028065871,-0.020831147,-0.006584754,-0.018368943,-0.02572811,0.032194253,-0.034872044,-0.049413543,0.064967416,0.010510023,-0.016796041,-0.041509237,0.0018675206,-0.019344784,-0.0019217613,-0.01296445,0.022498747,-0.06555835,0.03303993,-0.031794067,-0.0021819042,-0.022642244,-0.020871695,-0.032904666,-0.041029427,0.017181052,-0.04393466,-0.02059079,-0.00040074452,-0.024696885,0.020853959,0.20395279,-0.026252886 +2.4.99.21,"The enzyme, characterized from the archaea Methanococcus voltae and Haloferax volcanii, transfers a glycan component from dolichyl phosphooligosaccharide to external proteins. It is different from EC 2.4.99.18, dolichyl-diphosphooligosaccharide-protein glycotransferase, which uses dolichyl diphosphate as carrier compound in bacteria and eukaryotes. The enzyme participates in the N-glycosylation of proteins in some archaea. It requires Mn2+. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain. ",384,0.99999994,-0.02436335,-0.030429088,-0.071794346,-0.03108836,0.05266954,-0.037926618,-0.0936008,0.077625036,0.08095167,-0.069662765,0.011880967,-0.026192715,-0.020542689,0.032600593,-0.07131988,0.001335213,0.033059157,-0.004104759,-0.011665156,-0.01568204,0.07665666,0.05225839,-0.05371186,-0.020628707,0.020797785,-0.010690767,-0.023394136,-0.051468603,-0.02593412,-0.039939333,-0.04703665,-0.03737847,0.061399236,-0.069983326,0.024578787,0.12162067,-0.0075404095,-0.030471021,-0.010563091,-0.016602783,0.050183047,-0.0066580693,0.107530124,-0.019881502,-0.08195018,0.0069557684,0.028195497,-0.0037700473,-0.0032122824,0.05616032,-0.06453757,-0.08992088,-0.016333522,0.036379233,0.058023456,0.10590979,-0.08654259,0.014618899,0.013126743,0.015948296,-0.02933097,0.04803104,0.0053464174,0.027191792,-0.044836372,-0.059838768,0.023301542,-0.092751995,0.029339282,-0.04456654,-0.0865299,-0.026625555,0.04099769,-0.010473557,-0.0025576653,0.037294846,0.038440928,0.029197333,0.088692725,-0.091489024,0.04979201,0.013039519,-0.0005606997,0.037356976,-0.022818878,0.0076497747,0.032395847,0.016753614,0.02389091,-0.04097812,0.060663577,0.023772115,0.0038186356,-0.06213726,-0.09756069,0.029521378,0.040881112,0.07297645,0.020417362,0.021491254,0.023183497,-0.0055065467,-0.02203683,-0.06357925,-0.06900054,-0.04982089,0.011615579,0.10137113,0.03960239,0.037780832,0.09166855,0.047203027,0.06213557,0.008984509,0.0038323821,0.01619526,0.032013595,-0.11261256,-0.07717154,0.006904864,-0.0061237905,-0.0699276,0.07385781,0.032665346,-0.03400969,0.027490508,-0.04549797,3.697847e-33,0.105126426,0.0068115657,0.02331308,0.009001518,-0.0040438278,-0.0191497,-0.03353121,-0.006312697,-0.060445253,-0.009244,-0.050437607,-0.038173668,0.0047007347,0.10304045,0.025613932,0.018887259,0.04046012,-0.01806235,0.057432357,0.04294286,0.052873943,0.059532113,0.0062931688,0.010793847,0.09080579,0.028960142,-0.00030036597,-0.07592561,0.022044787,-0.0005130921,0.047837317,-0.13733888,-0.118471265,0.025344238,0.061880253,0.056568705,-0.066696696,-0.03273319,-0.046004433,-0.042177565,-0.009396651,0.05500659,-0.093592376,-0.005120783,0.08219578,-0.027949357,-0.006804995,0.019617213,-0.0023121708,0.08851717,0.011431961,-0.04310233,0.06418455,0.020916982,-0.09764713,0.04495281,-0.009575579,0.021811599,0.04679319,0.09620508,-0.04690985,0.08179599,-0.007654715,0.02086746,0.07668693,0.05507877,-0.062229287,-0.035083678,-0.00076559087,0.0697921,-0.033496812,-0.0705567,0.024434198,0.0696766,-0.06455212,-0.10358344,-0.06747729,-0.0046346807,0.02872746,-0.009408847,0.03789605,-0.057010412,0.031999383,-0.047220334,-0.096071675,0.047221873,-0.016450137,-0.0482784,0.013876902,0.055599745,0.033884734,-0.053669706,-0.050453473,0.051436268,-0.02739429,-5.562471e-33,0.10559893,-0.11781007,0.041778173,-0.036263455,-0.07630834,0.056462336,-0.02100831,-0.010931723,0.01860433,-0.08746006,0.077541515,0.0344149,0.047414914,-0.04856445,0.023054892,-0.0517329,-0.038105205,0.06665751,0.034974318,0.028874163,0.020797009,0.025910743,-0.031668704,0.008245287,0.011047013,0.009161054,0.015241056,0.06613789,-0.009460117,-0.00032863257,-0.0448082,0.06772402,-0.042321958,-0.09793901,-0.06521939,-0.0015680685,-0.13054182,-0.010934001,0.033454627,-0.019253734,-0.02343501,0.055949613,0.037859984,-0.03514304,-0.021722864,0.093902245,-0.10559157,0.0157161,0.07651906,-0.03443231,-0.002104975,-0.07478166,-0.035329584,0.0035670646,-0.011104856,0.032376014,0.029256353,0.037010133,0.011595606,-0.06388319,-0.066684105,-0.050247084,0.0063053244,0.019432366,0.040485706,0.08567962,0.01139676,-0.02501895,-0.0092782285,-0.0012600664,-0.008924912,-0.011693868,0.054284446,0.012263471,-0.019437946,-0.03503756,-0.04730903,0.007152301,0.032006048,-0.027978923,0.021633517,0.021821477,0.049589645,-0.05493402,0.051827084,-0.075478695,0.09914911,0.09467667,-0.00481571,0.0525338,-0.03627728,-0.01633675,-0.06277532,-0.0050795786,0.098377146,-4.788192e-08,0.043041963,-0.033379447,0.0036796308,-0.045325175,-0.06797684,0.040271297,0.0249433,0.038636703,0.03452224,-0.016734755,0.0052991016,0.06458956,-0.044585682,-0.06427096,-0.008725391,0.093803175,-0.071011834,-0.024850305,-0.040008504,0.057019837,-0.059253994,-0.042867113,-0.032970704,0.07512569,0.03658888,-0.023718778,0.04133893,0.09163926,-0.036741138,-0.0738545,-0.052354705,0.04422763,-0.003132426,0.0018726697,-0.043707788,0.019805107,-0.06889022,-0.04059005,-0.021162394,0.0502326,-0.019084161,-0.029888712,-0.05220427,-0.014039885,-0.043529063,-0.025146428,-0.019038504,0.058793895,-0.032032806,0.058068868,0.0033360848,-0.014264538,-0.006573825,-0.11005188,-0.091558054,-0.012410949,0.011218539,-0.05602804,-0.052122727,-0.00046079006,0.06921638,-0.057800647,0.15509209,-0.08070643 +2.5.1.129,"The enzyme produces the modified flavin cofactor prenylated FMNH2, which is required by EC 4.1.1.98, 4-hydroxy-3-polyprenylbenzoate decarboxylase, and EC 4.1.1.102, phenacrylate decarboxylase. The enzyme acts as a flavin prenyltransferase, linking a prenyl moiety to the flavin N-5 and C-6 atoms and thus adding a fourth non-aromatic ring to the flavin isoalloxazine group.",384,1.0,-0.0054146806,-0.025347838,-0.11556151,-0.0010080414,0.0892557,0.045987263,-0.060250983,0.01592814,0.037785016,-0.02823791,0.020012058,-0.045342423,-0.13733362,0.041586433,-0.05766898,-0.0067020264,-0.07148118,0.025169143,-0.021526434,-0.013134418,0.02025905,-0.020017501,0.06252247,-0.016481934,-0.056020636,-0.016266324,0.042192742,-0.040879194,0.06517799,-0.075613424,0.12651297,-0.026397401,0.0686685,0.008426356,-0.015398618,0.03765954,0.033992372,-0.11973926,0.07746029,0.05106924,-0.003790758,0.008149647,0.071471624,-0.09041235,0.006159263,0.007046489,0.036391098,0.054441083,0.027339755,0.058649596,0.0035664705,0.0035402887,-0.02481811,0.016824272,-0.016852064,0.019741124,-0.061681885,-0.047804058,-0.106775105,0.034711994,0.07110903,0.08930838,-0.022509506,-0.022544105,0.000905009,0.025132526,-0.032730017,-0.04187254,0.0926186,-0.005810318,-0.035651267,-0.042113166,-0.006858106,-0.008274182,-0.017697586,0.061420333,0.014651717,0.022349192,0.03540144,-0.01498016,0.0448343,-0.015894394,0.027146585,0.037604563,0.04425487,-0.024492513,-0.08235956,0.034920216,0.074421756,0.06991781,0.05483207,0.03244149,0.03320042,0.01651471,-0.045379527,0.085843906,0.031853754,0.112247914,-0.0018358952,0.010272017,-0.0019195587,-0.01363421,-0.009146004,-0.042278994,-0.059908323,-0.0843152,0.07029854,0.073485434,0.029493665,-0.020903274,-0.025581542,-0.002553303,0.06393288,-0.078196675,-0.04533229,0.11588193,-0.068558626,-0.03791452,-0.02983291,0.013135149,0.0057295733,0.014673922,0.06641674,0.060815435,-0.003988295,0.019904362,-0.176885,4.561287e-33,0.047045074,0.03577343,0.053906716,0.003875978,-0.0664622,-0.031281166,-0.030843426,0.027639922,-0.0666696,-0.06152643,-0.019772684,0.012578681,0.025976207,-0.057179,-0.019879727,-0.09664114,-0.045285996,-0.06828269,0.045242704,-0.026261378,0.055675495,0.034690652,-0.046715762,0.100095205,0.023247765,0.055960745,-0.0074613392,0.026524538,0.010270236,0.027662456,-0.03906486,-0.0997717,-0.021263435,-0.031782314,0.037019845,-0.0057879915,-0.107671686,-0.036052115,-0.07617047,0.0660035,0.04648743,-0.053105917,-0.033052385,-0.01763546,0.057661843,-0.02617714,-0.07148187,0.09125373,0.09961412,0.023182357,0.03639628,0.011079225,0.017111333,0.049412325,-0.04959809,0.017137947,-0.034497645,-0.020897487,0.064755954,-0.026664203,-0.0062983157,0.0007082872,-0.033517823,0.010646078,0.043252636,0.011760243,0.069736965,-0.059779428,0.012750368,0.06896256,-0.02182153,-0.058106728,0.031755846,0.062097054,0.107817516,-0.005222022,-0.026473163,-0.042257287,0.06794158,-0.01200385,-0.009011897,0.062019188,0.006035914,-0.021524405,-0.051181693,-0.03487992,-0.03477392,0.004929341,0.015361426,0.02678298,0.046356205,-0.1339779,0.013032023,-0.006879999,-0.0116831325,-3.9197946e-33,0.0046024816,-0.06362243,-0.07245606,-0.008034709,-0.031406686,0.057862513,0.024351878,-0.060896102,0.019593015,0.03470344,0.07520758,-0.07823367,0.01715051,-0.041265473,0.04201465,0.061676737,0.019117298,-0.027610855,0.08319759,0.0368907,0.030567173,0.032824237,0.03660539,0.0476334,-0.03809549,0.035382014,0.09212602,0.050152395,0.058487184,0.060701597,-0.08671757,0.011579929,-0.0023076371,-0.025738986,-0.06723433,0.0019081759,-0.02530412,0.02799634,-0.052633815,-0.028519092,0.0028511838,-0.016005594,0.00023827389,0.0067952224,0.0105541805,0.09283703,-0.0836735,-0.026324393,0.013802873,-0.02064789,-0.017281475,0.022096334,-0.065982625,-0.007167236,-0.0017214702,0.025549019,0.0020785567,0.013251174,0.06891861,0.020882115,-0.019810295,-0.10525977,0.08194665,-0.052587226,0.063558884,0.022929853,0.03746743,0.1254406,0.01110056,-0.044612516,0.027696496,-0.02744272,0.057466026,0.057584003,-0.061125584,-0.016342891,-0.033067975,0.0010969606,-0.009138191,-0.05129352,0.0054826885,-0.053378716,0.07393266,-0.0811951,0.012828394,-0.042438854,0.043093204,0.06993575,0.022650441,0.079172686,0.018283432,0.0042756014,-0.007847369,-0.016148519,0.022934929,-4.2940766e-08,-0.052595846,-0.093857504,0.011754928,-0.028593862,0.026327422,0.076177716,-0.013324673,-0.017862242,-0.058997575,-0.061114244,0.005289568,0.00872182,0.0006513784,0.027250495,0.0139353685,-0.035229217,-0.105876595,0.074930705,-0.042186543,-0.029836578,-0.051016,0.07536952,-0.07246607,-0.050678775,-0.017732356,0.02008805,0.00736735,0.03242041,0.047580115,-0.018531185,-0.025680948,0.05603645,0.054502133,-0.006697363,-0.20898013,-0.06955674,-0.00022060778,-0.06564547,-0.12184095,0.06494121,-0.006058685,-0.0053690756,-0.039519638,0.021416543,0.022902414,-0.024987742,0.039964784,0.025145276,0.020964121,0.008332449,0.044063684,-0.021595811,-0.044895586,-0.012401958,-0.053179882,-0.042681936,-0.04784785,-0.02001166,-0.036422536,-0.07036491,-0.03342424,0.0031930504,0.15374096,0.018750355 +2.5.1.130,"This enzyme, found in plants and cyanobacteria, catalyses a step in the synthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme catalyses the transfer of the phytyl chain synthesized by EC 1.3.1.83, geranylgeranyl diphosphate reductase, to 2-carboxy-1,4-naphthoquinone.",384,0.99999994,-0.08746413,0.050878968,-0.1004124,0.003093024,0.029848587,0.009833321,-0.008570349,0.021528535,-0.006670529,-0.018598035,0.07580826,-0.021549335,0.008889594,0.0017100603,-0.032694668,0.08391668,-0.09963154,0.04301481,0.001157342,0.0006720336,-0.032164823,-0.040524114,-0.012578217,0.029810166,0.09641421,-0.022945262,0.008457697,-0.010120389,-0.103389636,-0.011218531,-0.009339879,-0.09410347,0.04473514,-0.01284366,0.033807546,0.072662964,-0.08113025,-0.120332465,-0.011466146,0.07434026,0.0024245216,-0.03765551,-0.033903927,-0.014357699,-0.02092568,0.019229507,0.029147267,0.08739859,0.046437178,-0.05279524,-0.0877399,-0.021540448,-0.046415325,0.04430284,0.00088644656,0.0267096,-0.08282814,0.05578158,0.0007527293,0.06573522,0.06525628,-0.008254427,-0.030769045,-0.030066762,0.021396328,-0.0491973,-0.019858563,-0.056690626,0.068320096,-0.07307804,-0.041942004,-0.09284996,-0.024825878,-0.017588837,-0.024836998,0.009386416,-0.0068562245,0.022351287,0.047268894,-0.037253235,0.047261678,-0.004974267,-0.03948396,0.045253817,0.039269112,-0.0018567941,-0.006675731,0.045792848,0.049645953,-0.006393345,0.03493087,-0.03198073,-0.04164149,-0.038633738,-0.11231374,0.10345761,0.0046702297,0.015557481,0.0272543,-0.005316497,0.021610606,0.049974788,-0.015069792,-0.087299146,-0.05985492,0.0018432249,-0.03948618,0.075048216,-0.045500804,-0.04291823,-0.011041449,-0.013069218,-0.032102343,-0.023046685,-0.016502576,0.08234276,0.02342996,-0.039772604,-0.1321466,0.03608855,0.007639732,-0.028689304,0.04240946,0.023304822,-0.055627596,-0.03259774,-0.05746417,2.0268142e-33,0.056873135,0.06849842,0.04462912,-0.021100422,0.018870372,-0.024053233,-0.089271046,0.06532285,-0.08397887,-0.12913331,-0.081442095,-0.07781849,0.04756221,-0.004364914,-0.0727155,-0.00020618994,-0.032509115,-0.051250026,0.0882031,0.0928619,0.013516593,0.012002511,-0.005153807,0.045813862,-0.060287822,0.06702917,-0.044187266,0.008137255,0.0133462865,0.004501382,0.048828345,-0.08982281,-0.056795128,-0.006588762,-0.0018385362,-0.06328164,-0.09798082,-0.07250837,0.0012014105,0.045460414,-0.09715894,0.03654249,0.01496254,0.050606262,0.007896252,0.052945532,-0.044016078,0.06964379,0.06321334,0.056584317,0.0015225728,0.0045214365,0.077405535,0.0056397263,-0.05221673,0.03594781,0.013119789,-0.046954516,0.029225724,-0.013488131,0.0071258903,0.064867966,0.002902118,0.01000006,-0.010084112,0.01448637,-0.07937845,0.058360487,-0.018951518,0.048621465,-0.027435416,-0.013525927,0.027206654,-0.00700241,0.057818126,0.0012475797,-0.036116987,-0.055048175,-0.0584376,-0.008871174,-0.03916038,-0.05798776,0.02562483,-0.014046856,-0.05346274,-0.0113808485,-0.032392655,-0.023020407,0.0134318,0.069039114,0.0052518,0.0029657132,-0.016271628,-0.049451176,0.055563714,-2.9363854e-33,0.15778752,-0.079683505,-0.011222194,-0.08458369,0.0032479577,0.042390693,-0.014447888,-0.043683637,0.029452702,0.09854758,0.05738685,-0.0006602003,0.01504413,0.0067896075,0.015440117,0.016431455,0.014657809,0.11722575,-0.0017827027,-0.015032313,-0.03766915,0.060173064,0.0014174749,0.03464594,0.004542046,0.017476711,-0.03809544,0.022178715,0.072633184,0.07457294,-0.05815243,-0.039496746,-0.011467083,-0.02046267,0.03965663,0.096561566,-0.02494061,-0.024960656,0.056218952,0.094803356,0.040435962,-0.029939493,-0.020869412,-0.002069105,0.05307818,0.0455481,-0.06120289,0.112331055,-0.033155005,-0.0564998,0.076675646,0.12215271,-0.013362264,0.008110321,0.036517493,0.087439165,0.025920361,0.017229846,0.037222825,-0.03259479,-0.027209546,-0.16174911,0.003699635,-0.019508965,-0.00693568,0.04819976,0.03208493,0.10082385,-0.009388313,0.020328667,0.07852355,0.016940746,0.06513408,0.048234563,-0.07681394,-0.021398539,-0.021471852,-0.022052731,-0.014709065,-0.02849987,0.07031886,-0.081735164,0.041695174,-0.05472285,0.009002126,-0.06709931,0.025230633,0.05658984,-0.048583444,-0.015593744,-0.03301529,0.026376083,-0.03508063,0.06919209,0.07605143,-3.5999427e-08,0.026001533,-0.060529403,0.041580692,-0.047904473,0.092248894,0.026639666,-0.019245941,0.05200935,0.064578466,-0.014150176,0.059353847,0.080461,0.048422858,-0.019145707,0.017907163,0.046100758,0.016658016,0.00093724526,-0.002575819,0.07681027,-0.043420725,-0.031254042,-0.14231288,-0.030799164,-0.04406334,-0.064233616,0.015383768,0.035579804,-0.018054772,-0.08438197,0.08655826,0.025275404,0.037848502,0.0148518095,-0.07318639,0.023143265,-0.09456679,-0.04200698,-0.020696046,-0.02706229,-0.05921608,-0.0029611867,-0.03837735,0.04678301,-0.022762096,0.03847854,0.057470705,-0.020892054,-0.038776733,0.0457713,-0.01681082,0.020568244,0.04152185,-0.057306588,-0.082352385,0.032366317,0.015990034,-0.06357953,-0.0428691,-0.06535801,-0.007825489,0.04111359,0.14086401,0.02414849 +2.5.1.131,"The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, participates in the biosynthesis of the methanofuran cofactor.",384,1.0,-0.093038596,0.0009483634,-0.13323055,0.0019528966,0.05242568,0.04191574,-0.12371831,-0.005815258,0.016687429,-0.030390149,-0.055192135,-0.108948894,-0.08994641,0.014657606,-0.07179821,0.05180367,-0.065992825,0.010034702,0.022549449,0.0006665885,0.099848755,0.09641695,-0.014918803,-0.014276266,0.040309686,-0.012683647,0.022403806,-0.053627588,0.016739346,-0.0048801512,0.018756406,-0.042410642,0.08258599,-0.061618064,0.103566796,0.09618906,0.017487226,-0.08063383,0.11444967,0.04197017,0.06598271,0.042773414,0.087274686,-0.048488654,0.0049586953,-0.0033100368,0.00046585416,0.029666344,0.074282594,-0.0413236,-0.09433248,-0.049967702,-0.061801236,0.0010304257,0.06170434,0.07383062,-0.032199785,-0.07686646,-0.005951922,-0.022514878,0.08327483,0.035180163,0.010993482,0.021981834,-0.0102496045,-0.07373387,-0.01685301,-0.060597774,0.12991187,-0.06231897,-0.041454867,0.022216829,-0.021393541,-0.027436381,-0.04816986,0.025765097,-0.00078606023,-0.029502738,0.017600639,-0.05559367,0.02698098,0.0020901966,0.024943585,0.002317376,0.019060856,0.0072429636,0.02828582,0.007396082,0.041310742,-0.0099919,-0.009992082,-0.04471718,0.01650511,-0.08997823,-0.05934052,-0.055280387,0.0748835,0.05965123,-0.027236389,0.03940278,0.012608593,-0.002769926,-0.0015138788,-0.071382485,-0.072136685,-0.02044547,-0.0030374827,0.070169955,0.03302254,0.08745465,0.06699423,0.011318489,0.035677984,0.022895295,-0.031405676,0.04559872,-0.009879319,-0.0975025,-0.04476741,0.037565116,-0.009027428,-0.07846651,0.088256784,-0.010839211,-0.033047706,0.03260016,-0.066389196,1.2213739e-33,0.05534962,-0.011151222,-0.030131664,-0.098578915,0.039208867,-0.06691999,-0.06672651,0.017446963,-0.00266481,-0.060354196,-0.05786764,-0.005110711,0.04821207,-0.011582549,-0.06621512,0.021826666,0.020206831,-0.053669877,0.03113825,0.00025739244,-0.04010724,0.059169285,-0.05264039,0.027532509,0.0011176163,-0.03392294,0.00033425709,0.026905714,-0.02203295,0.017470898,0.033946306,-0.05836696,-0.060813073,0.050382774,0.09990126,0.016590295,-0.03319486,-0.07369789,-0.042636402,-0.033708964,0.01681834,0.009564117,-0.0014832892,-0.039644513,0.05444845,0.04964157,-0.010127604,0.09872938,0.04457978,0.0021931285,-0.013161432,0.006495159,0.050411444,0.008825769,-0.07998618,-0.02274562,0.0006399626,-0.05787915,0.10074747,0.0688753,-0.09862626,0.029236248,-0.029588519,0.10322154,-0.01864048,-0.006258334,-0.034739252,-0.04327956,0.05408143,0.06182774,-0.02422618,-0.036772158,-0.06997805,0.067663826,-0.013728304,-0.04630845,0.056753434,0.0036857899,-0.01382818,-0.0047423798,0.10173484,0.038941942,0.03091344,-0.021171011,-0.03785462,0.056839757,-0.019467056,-0.012316482,-0.034516886,0.04525442,0.023797717,-0.0764027,-0.047397893,0.057033785,0.0315462,-2.5728023e-33,0.087284386,-0.10757346,0.012389239,-0.11148181,-0.089179605,0.101741575,0.0042395988,-0.01946098,-0.0081705125,-0.05944635,0.060283337,0.0027764132,0.06647547,-0.011694325,0.043484833,-0.068420924,0.06150565,0.0819607,0.029815618,0.029898614,0.06485838,0.07504172,-0.03828967,-0.11322991,0.03593231,-0.018684814,-0.020271383,0.076236084,-0.06255781,0.03711009,-0.018878859,-0.0069350624,-0.07033876,-0.09545039,-0.09984629,-0.0008972427,-0.03504632,-0.039520588,0.055169757,-0.0013633841,0.03322013,0.060259473,-0.012531544,0.041142467,0.054288026,0.033596933,-0.09033958,-0.016095506,-0.04273522,-0.05380577,0.012065056,-0.051903974,0.04006114,-0.04294644,-0.007515932,0.05538342,0.017930621,0.05668926,0.047590874,-0.010524197,-0.031880353,-0.034612656,0.066177785,-0.0180954,0.06469161,0.05560754,-0.006733988,0.06396127,0.03368667,0.005208604,0.034232575,0.07736846,0.034735084,0.102221064,-0.051031873,-0.029480604,-0.1147234,-0.011278556,0.020437032,0.007498721,-0.0022374645,-0.018425986,0.081183605,-0.0343988,-0.0317837,-0.021641036,0.11662117,0.04990485,0.014768046,0.050555095,-0.005151361,0.015165173,-0.0811756,0.018291151,0.030168165,-2.7353382e-08,0.016720183,-0.03604558,0.05204749,-0.04079068,-0.0450794,0.039428532,0.054950587,-0.023698479,0.028340029,-0.016921258,0.032504264,0.052155152,-0.021410318,0.011514066,-0.038106296,0.0278228,-0.07444476,-0.010396142,-0.03225576,0.03134646,0.023426536,-0.0072848736,-0.006301264,0.03605573,-0.0065286695,-0.08021612,0.030170737,0.059437767,-0.0411875,-0.025820887,-0.048753593,0.015581007,0.010350028,-0.054412,-0.10837217,-0.005685258,-0.033566695,-0.051364213,-0.028124332,-0.04297824,0.06272811,0.00953845,-0.014610323,0.033822503,-0.022700695,-0.020575903,-0.000222344,0.034820396,-0.023947418,-0.023010215,0.061646026,-0.019738331,0.014260478,-0.054957125,-0.08715398,-0.088494085,0.01142313,-0.04013714,-0.09113521,0.02612584,0.054602426,0.012984437,0.14352983,0.021736555 +2.7.1.190,"Requires Mg2+. This bacterial enzyme phosphorylates many 4,6-disubstituted aminoglycoside antibiotics that have a hydroxyl group at position 2'', including kanamycin A, kanamycin B, tobramycin, dibekacin, arbekacin, amikacin, gentamicin C, sisomicin and netilmicin. In most, but not all, cases the phosphorylation confers resistance against the antibiotic. Some forms of the enzyme use ATP as a phosphate donor in appreciable amount. The enzyme is often found as a bifunctional enzyme that also catalyses 6'-aminoglycoside N-acetyltransferase activity. The bifunctional enzyme is the most clinically important aminoglycoside-modifying enzyme in Gram-positive bacteria, responsible for high-level resistance in both Enterococci and Staphylococci.",384,1.0,-0.017278135,-0.065582894,-0.03002104,-0.055165853,-0.003230571,-0.010887235,-0.06807977,0.069991216,0.05861835,0.0148853455,0.027590903,0.0066894097,0.10183558,0.0888206,-0.018491987,-0.039200086,-0.0306631,0.03480892,0.019689895,-0.043503147,0.050556406,0.0067391754,0.03805391,-0.025126867,0.01971196,-0.022905376,0.058584142,0.015744518,-0.04725044,-0.04420165,-0.028364599,-0.03989721,0.02397873,-0.02873237,0.004173114,0.10709901,-0.05273768,0.008889547,0.13335724,-0.026941765,-0.044659276,-0.022738123,0.084542505,-0.008655609,0.011387403,-0.063644774,0.10059229,0.03458917,0.0817802,0.035877757,-0.047474276,0.018550634,-0.03136959,0.03880272,0.10289559,0.022749977,-0.09463802,-0.0069842334,-0.012353559,-0.07458908,-0.024335112,-0.0128497165,0.0653251,0.001351251,-0.06486198,-0.027421243,0.0117194345,-0.050213568,0.044273816,0.004101364,-0.05171624,-0.033930283,0.03303838,0.034931097,0.04820814,0.012192975,-0.004428687,-0.029976357,-0.013980785,-0.06969582,0.031140365,-0.04087397,-0.001989655,0.13074869,0.058614958,-0.048923366,0.10025072,0.022966282,0.04518141,0.04601526,0.08896819,0.017829422,0.045138836,-0.0747455,-0.04028178,-0.07040191,-0.07175467,-0.0043154582,-0.0013755158,-0.013239353,0.0242056,0.036263697,0.053999864,-0.039577667,0.0074393875,0.008834293,0.040147074,1.873871e-05,0.03777211,-0.0030203261,0.04055056,0.042628594,0.035571907,0.010153071,-0.053981263,0.042423125,0.071389385,-0.11992872,-0.082141474,0.015612001,-0.0050876625,-0.045012023,0.047828406,0.029329114,-0.059657276,0.083544396,-0.048799146,4.8753647e-33,-0.07587471,0.04666603,0.058973208,-0.02927935,0.024817908,-0.044151302,-0.03158426,-0.06120558,-0.030365461,-0.08273022,-0.11851121,-0.029810704,0.019685306,0.08880424,0.0019255162,-0.044324562,-0.009097282,0.017067412,0.026172888,0.04311858,0.0051394883,-0.0011265896,-0.0038139406,0.0034394704,0.09024193,0.069110736,-0.003545237,0.01708283,0.06187882,-0.011519345,0.014549017,-0.05795985,-0.03190329,-0.008831497,0.053903997,-0.046000082,-0.048442435,0.010949941,0.056778528,0.0035656088,-0.12822829,-0.024043277,-0.045474853,0.028587047,0.065068476,-0.08645064,-0.020138023,0.04622972,-0.027895428,0.06289551,0.13901941,-0.07933757,0.03964878,-0.005379113,-0.039224852,0.018660538,-0.0025093493,0.021985577,0.10201945,0.08214416,-0.020972395,0.012560113,-0.0046057287,0.0075155385,0.007608887,-0.017193832,-0.027788607,-0.08905506,-0.019082243,0.0654687,-0.040059187,-0.047149837,-0.017850745,0.073494904,-0.02107721,0.02689625,-0.005933821,-0.030619554,0.08412387,-0.006178282,-0.029788982,0.024252482,0.04485695,-0.027711378,-0.051908363,0.009332966,-0.014779413,-0.11593679,-0.04236645,0.031836603,0.048197076,-0.04772648,-0.101484,0.022635026,0.07490302,-6.036352e-33,0.113574654,-0.07516245,0.09898411,-0.091958694,-0.07703506,0.06657256,0.049901053,-0.05388638,0.12325447,-0.037230723,0.07891358,-0.026557483,-0.00879514,-0.045597795,-0.0162449,-0.055261835,-0.005717405,0.07052889,-0.0172325,-0.018059192,0.027607666,0.102255724,-0.0013142824,0.03800327,0.010022409,0.049245227,-0.046683427,0.08057562,0.0036497328,0.02864517,-0.011049213,0.012473783,-0.05497093,-0.05346896,-0.023279306,0.09749739,-0.015852798,0.045269717,-0.063660875,0.049930252,0.028352613,0.05545651,0.04669047,0.034394596,-0.045748655,0.022996126,-0.048981868,0.025046919,0.0058604,-0.07508391,0.039182153,-0.004340278,0.038377274,0.0413737,0.082031846,0.033862866,0.0013763397,0.0034705936,0.03540329,-0.025053848,-0.07222118,-0.120380975,0.066570744,0.022040794,-0.0073240004,0.0001658346,-0.015484058,0.007813268,0.03910334,-0.028936459,0.017001968,0.030563131,0.017521093,-0.01985115,-0.0055035343,0.027920086,-0.08291768,-0.04521837,0.058029886,-0.03415369,0.0037696743,0.011214866,-0.035522558,-0.023987278,-0.048874322,-0.071921095,0.04942528,-0.0016274496,0.03541231,-0.0065716663,-0.028416803,-0.028874433,-0.054653335,-0.031395797,0.010014207,-4.7986436e-08,0.027227478,-0.046389922,0.055236332,-0.0509221,-0.003839969,-0.011159772,-0.07676529,-0.055366546,0.021935355,-0.058856867,0.057665262,0.04199655,-0.0055251867,-0.055418316,-0.049656063,0.018918656,-0.06972431,0.046672463,-0.026393982,-0.043317873,-0.06425267,-0.013802136,-0.16361046,0.07493231,0.08668701,-0.021330047,-0.0031399704,-0.026608111,-0.047861975,-0.061460454,0.0261501,-0.044481996,-0.06104604,-0.03205568,-0.07561363,-0.001732792,-0.0736889,0.0071270056,0.014952033,-0.007552415,0.038232934,-0.046462595,-0.021464081,-0.0049590613,-0.05366387,0.0885792,-0.024302883,0.04122873,-0.070625804,-0.0070527857,0.039272845,-0.011396398,-0.011921701,-0.04317023,-0.11852661,0.026949923,-0.009574557,-0.040166084,-0.02743677,-0.07597417,-0.022386212,0.005933405,0.17648005,-0.022234404 +2.7.4.31,"Requires Mg2+. The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, participates in the biosynthesis of the methanofuran cofactor.",384,1.0,-0.10315936,-0.02228472,-0.07134929,0.033218738,0.060236003,-0.023426667,-0.08498109,-0.0071001467,-0.031340975,-0.026148543,-0.043777157,-0.0971336,-0.039069127,0.003334962,-0.040186778,0.021801533,-0.015266631,0.049641322,0.015580076,0.0208212,0.13033855,0.08340672,-0.007752266,-0.016232904,0.031337958,0.0051024356,0.04357338,-0.054078426,0.057229545,0.008419479,0.0074564526,-0.011699386,0.0898141,-0.10381925,0.08796538,0.10648796,0.007964132,-0.04783528,0.057903826,-0.0016695991,0.05897894,0.0313476,0.14221025,-0.049633417,0.019085342,-0.071717024,0.05643838,-0.016818475,0.074692,-0.009219493,-0.08744567,-0.027478455,-0.09939171,-0.0033216532,0.05781282,0.06093323,-0.1029027,-0.06016785,-0.007054931,-0.03665594,0.053468652,0.04378759,-0.03509982,-0.005071162,0.027245456,-0.0445485,-0.0055982773,-0.09231941,0.11515597,-0.039794732,-0.016434828,0.019995976,-0.038622435,-0.029853193,-0.074892335,0.04368113,0.026099583,-0.06651104,0.049303886,-0.040928654,0.012516646,-0.012049638,0.06266825,0.029149355,0.03232475,0.008116142,0.060026996,0.036164645,0.026471147,0.037849247,0.04352057,-0.0033005932,0.025679493,-0.042938277,-0.038100626,-0.020754224,0.015018134,0.058255605,-0.034138355,0.052488312,0.003223819,0.032376327,0.0029556546,-0.030772055,-0.0887893,-0.013829561,-0.02593986,0.04466236,0.029159267,0.10238646,0.10568047,0.008514412,0.018551363,0.038718462,-0.002724021,0.060556874,-0.018713854,-0.13605799,-0.037283957,0.013066238,0.0010096108,-0.04756023,0.057941757,-0.0064618066,-0.044873115,0.038440324,-0.063795485,2.3385564e-33,0.00697777,-0.020412778,0.023443768,-0.056527447,-0.011407335,-0.025055604,-0.087350026,-0.017768033,0.015600075,-0.055128593,-0.07916754,-0.011273127,0.020203153,0.01269356,-0.060335692,-0.010600235,0.020981515,-0.04422064,0.077838205,0.01751206,-0.052269068,0.092892684,-0.028043168,0.005962436,0.021718781,0.03327747,0.033662565,-0.041772485,0.0018357211,0.03150226,0.059334323,-0.109661646,-0.04340367,0.070248015,0.08679825,0.012611506,-0.026623216,-0.082203664,-0.042848572,-0.027052904,-0.031288054,0.0065186964,-0.035971716,-0.017994687,0.059138477,-0.0170457,0.021783814,0.07690366,0.020718347,0.03923464,0.016819427,0.030331267,0.010387709,0.04388325,-0.100574374,-0.004256621,-0.009509329,-0.02087839,0.12207993,0.051741067,-0.07119823,0.031010343,0.0112663945,0.11227853,0.035154954,0.015521845,-0.06621442,-0.06753663,0.027230019,0.061941378,-0.009983015,-0.074989125,-0.035313703,0.07765627,-0.028416945,-0.047552552,0.06130445,0.02978968,0.0018377696,0.006517708,0.05118294,0.015809804,0.024999084,-0.0018601306,-0.06490675,0.053911746,-0.02172426,-0.02653494,-0.028382689,0.045092802,0.028387994,-0.04696338,-0.046551544,0.075261906,0.021381278,-3.395967e-33,0.080067255,-0.07009476,0.03643089,-0.10928847,-0.11200915,0.078304105,0.023916692,-0.102173984,0.029135466,-0.048741803,0.065259084,0.010942925,0.04621367,-0.05483623,0.04049791,-0.095527515,0.04476831,0.08871042,-0.0054016677,0.009665254,0.06827381,0.10656458,-0.031058356,-0.06431694,0.043482054,-0.010156508,-0.006243775,0.05305954,-0.033571735,0.061247595,-0.008630733,0.049510725,-0.067127675,-0.0912892,-0.11024012,0.008939391,-0.011989781,-0.025247034,0.0022749163,0.03950312,0.023313947,0.088281445,0.029030697,0.06372971,0.044371285,0.018316386,-0.051213216,0.0023299295,-0.002270634,-0.08800737,0.008822651,-0.058395326,-0.01748881,-0.064442344,0.017428402,0.043246225,-0.0017241227,0.04209077,0.058710523,-0.030935593,-0.015279919,-0.036281068,0.06661024,-0.069231816,0.054560356,0.06273204,0.012009398,0.0534693,0.014447093,0.046054065,0.041069396,0.07152237,0.068547,0.072353706,-0.030379547,0.030459965,-0.10065712,-0.016236423,0.049451444,-0.05103717,-0.002259531,0.011686353,0.056095164,-0.021903763,-0.021207104,-0.08593896,0.0793667,0.058385175,0.025107274,0.009975797,-0.045461264,-0.028772568,-0.07960885,0.022267358,-0.0017040292,-3.0380416e-08,-0.029337814,-0.045997553,0.034075275,-0.06200885,-0.04322247,0.07382903,0.012460958,-0.051037677,0.05553441,-0.034331273,0.050991837,0.017529625,-0.026681192,0.0060926303,-0.038904957,0.020098677,-0.0636931,-0.0051311194,-0.062917836,-0.025944535,-0.0008204144,-0.0522024,-0.04128273,0.044080686,-0.0017124522,-0.091376305,0.014350339,0.08320115,-0.041840926,-0.013547132,-0.024947181,-0.0034104553,-0.0034984255,-0.046479702,-0.101649866,0.00856167,-0.029599933,-0.033943765,-0.03490977,-0.08816019,0.0027716272,-0.004508892,0.049941234,0.01768736,-0.046938594,-0.020623583,-0.011625163,0.04139968,-0.051143333,0.012076742,0.056035534,-0.048966978,-0.0075698458,-0.054111958,-0.06248679,-0.07449416,0.034607563,-0.049438585,-0.09700927,-0.02313676,0.04995586,0.028674869,0.091086015,-0.0071263434 +3.1.3.98,"The enzyme, characterized from roses, is involved in a cytosolic pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance. In vitro the enzyme also acts on (2E,6E)-farnesyl diphosphate.",384,0.99999994,-0.04800661,-0.050658695,0.024930516,0.050616883,0.059194993,0.07562396,-0.03935582,-0.0034486363,0.10828825,-0.030792855,0.02800578,-0.009338908,-0.11514813,0.0019181649,0.04620853,0.08051453,-0.06288857,0.014616237,-0.0077272663,-0.0031416337,0.09552715,0.0155387595,0.016928896,-0.042177252,-0.021511847,0.007589008,0.044783164,-0.003704656,-0.0074478504,-0.092251405,0.08272921,0.07345747,-0.004384404,-0.035946812,-0.056356873,0.04486083,0.027796336,-0.08258925,0.062243972,-0.0013300412,0.06407503,-0.028199112,0.01674878,0.03435084,0.013581104,-0.0117400065,0.052878793,0.028649107,0.010244604,0.008911835,4.4554647e-05,-0.06692325,-0.04309633,-0.03911288,0.026343683,-0.02565913,0.03887359,-0.028503234,-0.03304483,0.035163097,0.04459197,0.0075193536,-0.04330299,0.03057878,-0.057422567,-0.09153686,0.0031073324,0.025665458,0.022916263,-0.1033748,-0.04983862,-0.051417705,-0.029889164,-0.016540017,-0.020800315,-0.018267222,-0.01189294,0.034505498,-0.016055986,-0.061309747,0.078090206,0.018867178,-0.015698284,0.17482397,0.041217364,0.0048143305,-0.021558769,-0.06113199,-0.02877597,0.018238232,-0.015406275,-0.08474099,-0.111135654,-0.033886172,-0.092201784,0.0028670356,0.0693253,-0.011192807,-0.024991056,0.012741189,0.030462677,0.070710875,-0.076569505,-0.030982563,-0.08176792,-0.015561018,-0.07022277,-0.015735805,0.0064778877,-0.013493832,0.002260259,-0.02103806,0.041110106,-0.0025068156,-0.048284806,-0.010829851,-0.0089795515,-0.07593845,0.011847278,0.023638833,-0.049293336,0.002578125,0.09109849,0.07855627,-0.047207735,-0.052117314,-0.04066833,7.340876e-34,-0.043650854,0.0754967,-0.02303284,0.013324801,0.016692009,-0.076740324,0.03388347,0.0451702,-0.07490898,-0.0068680183,-0.09169834,-0.013723312,-0.014175659,0.033687636,-0.0023869534,-0.0004441737,0.02579967,0.009845313,0.03614042,-0.07755885,-0.01516896,0.0124117825,-0.078638695,0.018652951,-0.05072297,0.009973212,-0.04433569,0.03693485,0.035261646,-0.01564175,0.025526935,0.00043617774,0.058550514,0.03196131,0.03257463,-0.0062044095,-0.04395547,-0.031782594,-0.0010219034,0.0134016555,-0.025657162,0.03365878,0.0089946585,0.00484502,0.0035016434,0.03530372,-0.11107442,0.030304985,0.0992072,-0.005730419,0.02855574,-0.042395476,0.13470103,0.112476155,-0.090680175,0.05418496,-0.09889213,-0.0032208306,0.00040316678,-0.032998957,-0.026704187,0.041028272,-0.056255475,0.018747374,-0.030822342,0.027501933,-0.0152515685,-0.052696038,0.004466286,0.16491687,0.014487778,0.07025245,-0.023680529,-0.02363651,0.024960328,-0.0043987124,0.016947307,0.08942639,0.12778239,0.022941414,-0.00023807463,-0.084975384,0.0075608287,-0.023865087,-0.02311926,-0.036711477,-0.007428615,0.04652593,-0.03181248,0.047095478,0.10269842,-0.06663088,0.032821383,-0.04833524,0.018667383,-2.2500964e-33,0.06682003,-0.042171292,0.039630666,-0.09358986,-0.0023889535,0.0845652,-0.0133146085,-0.0067309723,-0.011542216,0.037289426,0.002312734,0.016873062,0.06946767,-0.021667492,-0.042998996,-0.01012549,0.02517377,0.115531854,-0.013397436,0.029857028,-0.06777654,0.05307878,0.041819334,-0.014318824,-0.030675754,-0.033619776,0.023099989,0.010937404,-0.034725603,0.029470617,0.0457661,-0.04659817,-0.060496986,-0.014102703,-0.006776579,0.038913082,-0.051321086,0.034990832,-0.041647214,0.059317075,-0.0077271033,-0.004864313,-0.029633215,0.07460905,0.10713117,-0.0030705812,-0.18468302,0.03281111,0.029581474,-0.04848399,0.04028591,0.034528237,0.008962325,0.017664138,-0.02230302,-0.019798053,0.004719087,-0.07164867,0.025517767,-0.001831844,-0.09622066,-0.077646196,-0.06397657,0.003995033,0.02840181,-0.007243187,-0.04267277,0.08578779,0.003091045,0.016506195,0.06724039,0.056944385,0.0022952356,0.026941907,-0.04670004,-0.047722936,-0.08834661,-0.065976426,-0.0099031795,-0.005532044,-0.042640176,0.030382019,-0.026354313,-0.051841177,-0.06233513,-0.13452275,0.039929878,0.08317219,0.016868087,0.005869043,-0.012918218,0.043380793,-0.02389762,-0.008413288,0.048944656,-3.4664154e-08,-0.032662917,-0.11049712,0.044601917,0.00887095,-0.013762747,0.051632106,0.038599823,0.035035234,-0.0072941696,0.005081021,-0.05193007,0.14092012,0.026702695,0.008844033,0.07754606,0.008002042,0.05090835,0.021048144,-0.039784033,-0.050359793,0.038054746,0.06234038,-0.016822897,0.036527175,0.024537133,-0.05698696,0.03126632,0.021418547,-0.04148813,-0.03685983,0.050577573,0.0210774,-0.015448994,0.028897807,-0.103068404,0.05734226,0.062898554,-0.042160675,-0.060265306,-0.016560633,-0.0090583395,-0.04292536,-0.095922984,-0.0227356,-0.025254458,-0.008897002,0.054309167,-0.02484826,0.028645137,0.03299254,-0.015865223,0.052890196,-0.026293874,-0.024959883,-0.091097675,-0.054578625,-0.030919287,0.0084315,0.026891612,-0.045069594,0.071179874,0.04298347,0.21069665,-0.017288228 +3.5.1.119,"The enzyme has been characterized from the bacterium Mycobacterium tuberculosis. It catalyses the hydrolysis of the amido group of the C-terminal glutamine of prokaryotic ubiquitin-like protein (Pup), thus activating it for ligation to target proteins, a process catalysed by EC 6.3.1.19, prokaryotic ubiquitin-like protein ligase. The reaction requires ATP as cofactor but not its hydrolysis. The enzyme also catalyses the hydrolytic cleavage of the bond formed by the ligase, between an epsilon-amino group of a lysine residue of the target protein and the gamma-carboxylate of the C-terminal glutamate of the prokaryotic ubiquitin-like protein. ",384,1.0,-0.050126426,-0.018718729,-0.05468597,0.013132745,0.023743412,0.03480233,-0.000848572,0.059331004,-0.0002488868,-0.012868076,0.0076766,-0.038564876,0.06995975,0.056505013,-0.05711423,-0.021341717,-0.05002594,-0.042273965,0.0010275581,-0.037868332,0.038200416,0.0995187,-0.02246561,-0.04488347,0.06113654,-0.027588157,0.1198994,-0.012261123,0.011517632,-0.09336059,-0.007286762,-0.09871432,-0.005981354,-0.0644702,0.07882868,0.08907878,-0.046599947,-0.12811771,0.050823823,-0.05967961,0.052946296,-0.012584349,0.025527973,0.020945044,0.025183046,0.038895596,0.002952304,0.067258984,0.09442787,0.045734968,-0.037342224,-0.019289516,-0.009754112,0.042173762,0.039270945,0.011777061,-0.06627178,0.012336977,0.071543455,0.009760525,-0.03315626,0.028729035,0.047529247,0.003621918,0.044528328,-0.061378688,-0.006089392,-0.037599802,0.04800403,-0.010636018,-0.050501984,-0.044787295,-0.031730328,0.07156494,-0.05472931,-0.0018362713,-0.06746022,-0.0012182308,-0.008571869,0.051331833,-0.004601114,-0.06062178,0.094757974,0.034126937,0.015103763,-0.016884793,0.0528969,-0.032485317,0.0436683,0.044870228,0.03948008,-0.0354645,0.020652076,0.010926817,-0.08771046,-0.012542331,0.051849477,0.013169738,-0.023703251,0.0007434579,0.010378133,0.03575244,-0.014012998,-0.05889414,0.042172268,0.058970675,-0.021210117,0.13126059,0.09987836,0.008552151,-0.058881585,-0.008605561,-0.01934418,-0.05140298,-0.027490221,0.030961534,0.057592418,-0.07020469,-0.059050553,-0.034387052,0.0108634615,-0.026794443,-0.021187883,0.04722857,-0.0636565,-0.016751405,-0.12931941,2.3289447e-33,0.069533326,-0.05957282,0.0068355645,-0.009664417,-0.035105992,-0.0068026963,-0.090474755,0.015002673,-0.028402971,-0.09283179,-0.043568514,-0.05007583,0.028178923,0.034102347,-0.011475672,-0.044993564,-0.01740036,-0.029001096,0.07500347,0.087554544,-0.019882562,-0.0057087233,-0.013198814,0.010210684,0.012534145,0.048177242,0.00044985898,0.054048542,0.030885918,0.00071621354,-0.056887493,-0.052495398,-0.096595585,0.026306525,-0.01203007,-0.02890375,-0.028971663,-0.03959309,0.030108232,0.0839264,0.014413238,-0.019557208,-0.10188771,-0.07277002,0.12011028,-0.042643208,0.0072187176,0.106324635,-0.054549485,0.0022543618,0.095972314,-0.039145958,0.08260153,-0.014050642,-0.069094434,0.012867458,-0.021174565,0.052833453,0.0694491,0.049056653,0.03280677,0.0080460245,-0.029427597,0.05687004,-0.029808331,0.020126913,-0.047342215,0.0051404596,0.044930104,0.018880233,-0.08000699,0.0015601001,0.06349943,-0.013333715,-0.026980557,-0.029578818,-0.08346943,0.00072198594,0.07986687,0.019511424,0.017392319,0.034820504,-0.020121597,0.010750311,0.033187058,-0.025702424,-0.016626103,-0.06949908,-0.07362579,-0.005490249,0.054916374,-0.04913909,-0.031422082,0.0874414,-0.004971083,-3.7431913e-33,0.16633211,-0.08554698,0.039918654,-0.045509446,0.056205325,-0.029314134,0.06207625,-0.041660096,-0.009016486,-0.038671013,0.057706095,-0.054358777,0.02064013,-0.012306914,-0.020029746,-0.01631847,-0.021741642,0.04856498,-0.029135354,0.011153243,0.0043251636,-0.004778256,0.027647916,-0.080387846,-0.022206565,0.014297416,-0.026091885,0.018254723,0.024961043,0.06751766,-0.059305962,0.022445714,-0.024011757,-0.043085955,-0.08501601,0.046758976,-0.04004976,-0.0065290825,0.14042005,-0.0811018,0.0803993,0.031670656,-0.06707443,-0.017149925,0.04062956,0.09144174,-0.02405592,-0.03417076,-0.06930821,-0.054484,0.056587532,0.002598369,-0.02541528,-0.002161382,-0.098078296,0.043453705,0.05357988,-0.012166207,0.08006839,0.04030402,-0.03669307,0.020777557,0.033560883,0.03636909,-0.0013638923,0.06822116,0.033633333,0.064154066,0.040300217,-0.05890807,0.083272174,-0.046770174,0.06981112,0.04922548,0.070633166,0.008093127,-0.034005843,-0.019097071,0.0020232599,-0.02585548,-0.060940392,-0.020179782,-0.0315684,-0.058854427,0.03497275,-0.0429267,0.0052659283,0.090242736,-0.014474582,0.07482605,-0.036786728,-0.02004881,-0.033455614,0.062329937,0.08228934,-4.2415603e-08,0.0025259322,-0.04619503,-0.0024114905,-0.03365239,0.092099644,0.108885445,-0.03422308,-0.017378483,0.051330324,-0.06479707,0.04230354,-0.025717355,-0.07895595,-0.032865092,0.04145449,0.02102695,-0.028632099,0.0012562192,-0.011384255,0.007097109,-0.06735326,-0.007089187,-0.05078695,0.07869727,-0.00440714,-0.06629519,0.013348023,0.07455697,-0.065833986,-0.042186353,-0.097510025,0.0777762,-0.05097539,-0.0964031,-0.07316878,0.0032019166,0.012741341,-0.051423017,0.022854408,0.017087156,0.020657487,-0.0056235045,-0.039678752,-0.020949973,0.03608542,0.061892897,0.019934604,0.06347733,-0.042166933,0.0073389793,0.071265996,-0.06494411,-0.056877527,-0.07419341,-0.052604135,0.05970904,-0.04647959,-0.077987656,-0.03397473,-0.08578634,0.024240678,0.007377358,0.15248649,-0.053782426 +4.1.1.102,"The enzyme, found in fungi, catalyses the decarboxylation of phenacrylic acids present in plant cell walls. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.",384,0.99999994,-0.034473013,-0.016931634,-0.11545204,-0.005049309,0.12777993,0.07054623,-0.096361704,-0.0013439578,0.07488197,0.029456008,0.074715,-0.07755187,-0.13964897,-0.0098213805,-0.055769134,-0.021500088,-0.10878365,0.055761397,-0.027462944,-0.05382673,0.06281833,0.055584826,0.016211074,0.0045439303,0.013529487,-0.021169288,-0.004239967,-0.047843643,0.029487183,-0.11381176,0.04914415,0.0034141722,0.067211635,0.026557343,-0.03022914,0.10266335,-0.02881837,-0.14921467,0.12585475,0.020663565,-0.029088264,-0.016718099,0.043187287,-0.056318883,-0.026088774,0.007249014,0.019840367,0.0706353,0.017245948,-0.0045884387,-0.01920102,0.037837036,-0.027777273,-0.035474464,-0.04497193,0.04207532,-0.015427843,0.005939945,0.007804627,0.021103611,0.07611697,0.039453745,-0.023878895,-0.009186133,-0.04204055,-0.006167213,-0.019710338,-0.041161027,0.076542675,-0.005492549,-0.035573296,-0.025260786,-0.008948608,-0.00043768098,0.017172636,0.073187284,-0.055501785,0.0021113108,0.03111041,0.01925739,0.07026618,0.0047513978,-0.034966834,0.045465365,0.018613411,-0.037447818,-0.056708805,0.05592718,0.08050167,0.03564523,0.080356754,0.014933448,0.019948807,0.041274756,-0.10864464,0.1023579,0.04694287,0.033537205,0.020218078,-0.02483127,-0.0171605,-0.006597401,0.033497058,-0.021972794,-0.07220075,-0.028935347,-0.007399987,0.04974884,0.019483719,0.007847397,-0.010159074,-0.037778925,0.0345903,-0.04105882,-0.004741302,0.10122013,-0.0021940283,-0.12122427,-0.045623023,-0.024000054,0.036618777,-0.045011707,0.008467667,0.054587014,-0.031550214,0.0033214563,-0.14869931,2.9304207e-33,0.087797716,0.023702873,-0.014165902,-0.0028373527,-0.016329477,-0.048372988,-0.021151792,0.043935895,-0.03577964,-0.07092556,-0.060713958,-0.009762298,-0.0052727032,-0.006872853,-0.031740837,-0.046053678,-0.030973447,-0.09551884,0.03652161,0.035708617,0.014594813,0.006266492,-0.053402405,0.05842708,0.020608509,0.065277256,0.00045309387,-0.037541173,0.036165345,0.00076152384,0.033604514,-0.13749497,0.013350587,0.05429219,0.04244876,0.024036253,-0.08783774,-0.04361066,-0.040009726,0.045425724,0.02816652,0.004233198,0.039192136,-0.008039298,0.069857694,-0.02169031,-0.03336769,0.079046145,0.036415786,0.04534566,0.04781241,0.062153287,0.04051115,0.051950723,-0.02182825,0.040862754,-0.03826688,0.008325083,0.011714241,0.030257167,-0.007384506,0.023848595,-0.016462576,0.054303765,-0.020236967,0.020739062,-0.048076633,-0.048197806,0.052244935,0.042473,-0.054226093,-0.060974687,0.018760541,0.02989597,0.08584553,0.018754024,-0.033411555,0.013082592,-0.030003043,-0.013230631,-0.025151,0.03889687,-0.01666454,0.0038092702,-0.046526544,-0.0033694964,-0.06192259,-0.024320483,-0.04844188,0.03136825,0.01255747,-0.077497,-0.003076888,0.008733944,0.022875097,-3.4575737e-33,0.10267275,-0.10313561,-0.00011469891,-0.023821225,-0.028572932,0.075070396,-0.012127207,-0.06719111,0.03258432,0.016353305,-0.008492718,-0.0021649306,0.045529097,-0.015361317,0.10720228,0.03310333,0.102744184,0.0663923,0.012573846,0.023639603,-0.028143687,0.09433679,0.010709464,0.011676527,0.024403455,0.0038328397,0.025649037,0.025080714,0.020918665,0.048671946,-0.07919019,0.006631109,-0.021728143,-0.0034902,-0.07171295,-0.017672515,-0.03167448,-0.028769199,-0.02992091,0.019311208,0.010053469,-0.0018237045,-0.021035712,0.013362941,0.04250443,0.04787829,-0.07916735,0.026929775,-0.018752804,-0.01960382,-0.010284073,0.06438649,-0.046818014,-0.03367387,0.040260173,0.06320923,0.032421548,0.02834344,0.06130344,0.002939671,-0.06334752,-0.09679093,0.030642398,-0.04112384,0.04466735,0.046223097,0.022948748,0.10675401,0.05441047,-0.04159203,0.10554961,0.06267467,0.010022283,0.092803806,-0.06378157,0.016661635,-0.04744663,-0.04176744,0.0056516714,-0.01900836,-0.015569856,-0.026297763,0.07622623,-0.13029069,0.042496298,-0.12094767,0.019443616,0.050363477,-0.014236326,0.07517703,-0.024948088,-0.06220527,-0.006414008,-0.026855385,0.07283734,-3.4858303e-08,-0.05339785,-0.03434698,0.011770437,-0.086280175,0.025336549,0.071705624,0.05018424,0.04861107,-0.018303486,-0.06725514,-0.0044639744,0.01855583,0.0012798556,0.060204588,0.03222249,-0.00034179367,-0.058236245,0.044070978,-0.067808464,0.011392502,-0.03427523,0.018394202,-0.10122452,0.02496808,-0.026018366,-0.02435529,-0.022846613,0.009243211,0.010537966,0.013078824,0.0090219835,0.055296984,0.0713201,-0.04207932,-0.11269954,-0.044649385,0.03834803,-0.0894519,-0.07775423,0.060612094,-0.015771199,-0.01940049,-0.060194336,-0.015708353,-0.027701668,0.008015776,0.03246055,0.047592968,0.013874265,0.023203274,0.07537577,-0.021838496,-0.07446863,-0.04442331,-0.08477673,-0.10249997,0.010321975,-0.054329325,-0.0208222,-0.05889426,-0.024419826,0.06329556,0.20940258,-0.02495822 +4.2.1.159,"The enzyme participates in the biosynthesis of several deoxysugars, including beta-L-4-epi-vancosamine, alpha-L-megosamine, L- and D-olivose, D-oliose, D-mycarose, forosamine and beta-L-digitoxose. In vitro the intermediate can undergo a spontaneous decomposition to maltol [2,3].",384,1.0,-0.039301164,-0.03362216,-0.037283693,0.040048003,0.012946688,-0.045721404,-0.04726626,-0.004632862,0.04148861,0.049305283,-0.039497126,0.0020982635,-0.062407438,-0.0333525,-0.039532416,0.0571028,-0.0837724,0.008094555,-0.027053626,0.06335842,0.12702623,0.020099746,-0.038534626,0.00032618316,0.030821128,0.0036149456,0.04614879,0.032606117,-0.008002301,-0.069863565,-0.017637277,-0.07548518,0.06412384,-0.027381541,0.029189978,0.09729018,-0.0033990287,-0.033818696,0.045745406,-0.010298541,0.04746803,-0.0075693023,-0.06502551,0.0758092,-0.119859405,-0.07433082,-0.116806924,-0.031435773,0.036226574,-0.026377607,-0.0068152905,-0.029622989,-0.064187296,0.06932342,-0.013117149,-0.027340807,0.0108751375,0.045559626,-0.08362296,0.06586715,0.0563034,0.1626681,-0.045575403,0.019635115,0.006780865,-0.047398087,0.018954346,-0.043932144,-0.023200404,-0.038275983,-0.0024493632,-0.11086239,0.038383614,0.030827407,-0.050065145,-0.009282415,0.038052533,-0.014327493,-0.030861769,0.024322031,0.052707806,0.0043817083,0.05023636,0.039016396,-0.030852487,0.012669715,0.0047627925,-0.035212908,0.08372197,0.05891245,-0.017171253,-0.032696687,-0.05717027,-0.04071776,0.030840036,-0.0153452,0.108905435,-0.002657085,0.038657803,-0.01621695,-0.044916455,0.0019062551,-0.017559817,-0.076820865,-0.0471379,0.024697354,0.009599413,0.051012527,0.030861698,-0.02470802,0.028453669,-0.0044941013,0.09077403,0.09030491,-0.055246677,0.09197354,-0.0145054925,-0.10037143,0.033003293,-0.027066156,0.061986785,0.0044871303,0.053847946,0.0035972926,-0.05913175,0.04994002,-0.027958889,-2.1370225e-33,0.07557901,-0.0011742827,-0.04349933,0.04153022,-0.05283062,0.002797028,-0.06564079,0.030014377,-0.007801118,0.028467843,-0.12710801,-0.13822173,0.072065905,0.012326181,-0.0047936495,0.0055428804,-0.02197819,-0.047820773,0.1036808,0.039723713,-0.019089535,0.04199011,-0.06746184,-0.009617286,-0.050279148,0.13763659,-0.037574597,-0.029420935,0.0031698886,0.01920612,0.050928224,-0.084987,-0.05756312,0.007281298,0.022313604,0.032776218,-0.05350816,0.02990254,0.03605783,0.004539837,0.102130435,-0.020388843,-0.015497738,-0.086350374,0.029532341,-0.0047589554,-0.038285952,0.10191914,0.015232035,0.07769778,0.03690892,-0.04106895,-0.013555582,0.03394665,-0.068409875,0.053147122,-0.0173675,-0.07429896,0.04157373,0.046060354,0.0062434943,0.046081807,0.0070225224,-0.00518004,0.08365274,-0.019817138,-0.012651926,-0.02810472,-0.09024729,0.0072928355,-0.10873694,-0.04980902,0.04847669,-0.084155135,0.021142093,-0.018558403,-0.021668183,0.06634024,0.03430483,0.009175768,0.06841149,0.006170288,-0.041169133,-0.052388564,0.020055259,0.041891497,-0.004305852,0.024975086,-0.057816572,0.079833314,0.035860218,-0.094353944,-0.06367504,-0.026017347,0.010242228,-1.7115565e-33,0.056785304,-0.12851486,0.10753012,-0.07247381,-0.041368246,0.0748397,0.014457948,-0.018027198,-0.03425953,0.069158144,0.009748812,0.059398673,0.0074351747,-0.02294366,0.0034406255,0.033916276,-0.063645266,-0.0047938847,0.0155714145,-0.053027686,0.020280356,0.10196928,-0.06478475,-0.010230898,0.08520232,-0.07123521,0.036604702,0.063628845,0.043693718,0.020233294,0.06765397,-0.03215872,0.042204894,0.0026307015,-0.024603099,0.04302385,-0.1020936,-0.022361211,0.010212491,0.013992773,-0.0638493,0.022892507,0.02721609,0.040600285,0.06664925,0.015596463,-0.11690131,-0.046511788,0.012159413,0.018944904,0.040900152,0.015863884,-0.037697904,-0.0096059,-0.022972034,0.032295566,-0.021708395,-0.014981617,0.027787969,-0.010276641,-0.053358298,-0.017737206,0.034206472,0.012922674,0.026865825,0.01983726,-0.015210817,0.06408297,-0.006762929,-0.02405822,0.05402917,-0.05159255,-0.017813915,0.0124976775,-0.042594794,-0.06013035,-0.10115191,0.018660443,-0.00018211873,-0.016152374,-0.020489356,0.037773028,0.052917328,-0.054906726,-0.060738545,-0.06914052,0.022160579,0.14184892,-0.014893015,-0.01972938,0.000848243,-0.021971561,-0.017528372,0.017841566,0.17527463,-4.1095262e-08,0.012150499,-0.005866242,0.009165203,-0.0033444087,-0.05208584,0.016683862,-0.010820443,0.050130766,0.019431217,0.025356567,0.011892295,0.104146436,-0.050274976,0.05730442,0.032337535,0.023585934,0.007320628,0.042470478,-0.007629855,0.01926694,-0.05129039,-0.029632034,-0.08569494,-0.0068230825,0.0007292408,-0.09176009,0.026835302,0.031923912,0.009500617,-0.010604693,0.0011826683,0.10676241,-0.01285584,-0.09767404,-0.11217829,-0.019383356,-0.06459299,-0.06395687,0.029496413,-0.007360633,0.021021152,-0.023595639,-0.027634483,0.006750045,-0.04359576,0.009020143,0.04311567,-0.03402824,-0.01109598,-0.016820516,0.008716228,0.0027554869,-0.06339948,-0.04363085,-0.06925443,0.025872149,-0.048226725,0.027929379,-0.022797156,-0.046350565,-0.002516115,0.0789093,0.13450006,-0.03656735 +4.2.1.160,The enzyme participates in a folate biosynthesis pathway in Chlamydia.,384,1.0,-0.011128405,-0.008992332,-0.14647885,-0.040417597,0.02687305,0.07646731,-0.065768614,0.010797602,0.06157358,-0.019563017,0.02033518,-0.018598713,0.036603495,0.0145903155,-0.018504476,0.054870307,-0.13188313,-0.08261769,-0.037134048,-0.033172973,0.048739035,0.061872777,-0.0046494403,0.00900179,-0.049912285,-0.0148423305,0.059970267,-0.035292093,-0.046464473,-0.017144728,-0.050977618,0.01661648,0.060181953,0.0077048717,0.027678639,0.122928284,-0.108601555,-0.060665615,0.11863096,0.04033059,0.012034395,-0.050287347,-0.026482657,-0.05998648,-0.051783077,0.018989304,0.11608715,-0.016143022,0.03954392,0.051281437,-0.019363012,-0.013344448,0.042787552,0.044137876,0.03818819,0.02495405,-0.00039971955,-0.0006888339,-0.015636735,0.061607383,-0.028247641,-0.019912247,-0.010035567,0.026940942,0.014181737,-0.052659463,-0.0037181776,-0.049383253,0.017269231,-0.075660564,-0.041311692,0.031214824,-0.018864112,0.013400457,0.05055478,-0.017012745,-0.021809317,-0.009640731,-0.030236963,0.0007766271,-0.014629316,0.021819994,0.01332102,0.056911256,0.111404575,-0.025815783,0.06384762,0.035037532,-0.0065944777,0.018280452,0.03157205,-0.069457434,-0.038916923,0.02844178,-0.11124539,-0.04040601,0.059442755,-0.09899963,0.017274767,-0.027725367,-0.068621226,-0.017237127,0.0070135146,-0.023782754,-0.016256878,-0.0090451585,0.014277169,0.09539014,-0.09494145,-0.040150043,0.028209513,-0.03279158,0.03725749,0.07815037,0.012623068,-0.0025368794,0.032225944,-0.067684144,-0.03371687,0.0410251,0.010150685,-0.026270106,0.03150365,0.07096709,-0.0846887,-0.01021146,-0.09323291,-1.44432155e-33,0.0009034047,0.088146776,-0.029988863,-0.045143332,0.022539852,0.039196428,-0.008035957,-0.007826158,0.064664446,-0.083929695,0.027592659,-0.04527505,0.06407328,-0.014535175,-0.035328846,-0.048854448,-0.006694234,-0.054975618,0.036027104,0.07146801,0.040904835,0.036774855,0.025940547,-0.07145346,-0.04603167,0.0084204255,0.036640618,0.07343281,0.038622975,0.017725887,-0.029583627,-0.037408926,-0.033170298,-0.070109755,0.0909384,0.06562954,-0.099930294,-0.019096518,-0.04746589,0.11767264,-0.058567844,-0.019009471,-0.052495036,-0.04845094,0.0014264592,0.043799438,-0.082093075,0.011115247,0.0027490659,0.058844984,0.057088237,0.008144578,0.0691128,-0.068761356,-0.009653333,-0.097071044,-0.033014566,-0.08328813,-0.009366079,0.050450254,0.011104433,-0.005655435,-0.009148974,0.027445296,-0.073498316,-0.09869292,0.02472834,-0.023438046,-0.02805024,-0.0047081863,-0.023295242,0.011634283,0.13395423,0.026781783,0.04474704,0.023713715,-0.04594272,-0.0049008946,0.06868472,-0.0125305755,0.03429717,-0.036596417,0.057881355,-0.033797532,-0.024694795,-0.03226191,-0.031537924,-0.01383072,-0.02576077,-0.031292394,0.026863834,-0.047044262,0.008200438,0.013851217,0.07265017,-1.2514471e-33,0.07006639,-0.08001686,0.08815597,-0.109010115,0.010789049,0.09733376,0.057438944,-0.05750083,0.016606964,0.058109697,0.016220182,0.004004496,0.0056680427,-0.031203372,0.08098325,0.020690454,0.020110106,0.04508824,-0.0023280934,0.0004144748,-0.04367144,0.040672235,-0.03333942,0.015010133,0.063618295,0.042012416,-0.016380692,0.049468577,0.024782766,0.018658167,-0.016470272,-0.055307753,-0.08225393,-0.04734164,0.029874591,0.07016293,-0.042164028,-0.028655829,0.049135808,0.010135507,0.01865157,0.02240514,0.07464973,0.021130232,-0.05072325,0.0949382,0.0028609699,0.018635387,0.027659634,-0.015935274,0.023105327,0.054103106,-0.019583154,0.02572843,-0.009056608,-0.008340844,-0.008641682,0.038876303,0.01811187,-0.06507111,-0.074152745,-0.07041814,-0.02497151,0.03364095,-0.035746466,-0.092353985,-0.048662018,0.028120859,0.0484535,0.042363815,0.07045348,0.023773842,0.07717681,0.037696585,-0.029902091,-0.010139809,-0.10251437,-0.0753648,0.008569885,0.040492542,0.032143094,-0.03675002,0.015568633,-0.0010884478,-0.047516983,-0.098236255,0.04842945,-0.013249058,-0.011363509,-0.005158111,0.020093134,-0.010536722,-0.027111994,0.012092107,0.09189054,-2.2793358e-08,0.0061661415,-0.10895586,-0.064310126,-0.046566684,0.072918795,0.034853566,-0.0524772,0.044784583,0.020760449,-0.0067568934,-0.034753885,0.04275893,0.035965703,0.039867137,-0.06866698,0.049863603,-0.026271315,0.021533549,0.046003614,0.024447005,-0.072435275,-0.011430951,-0.1529146,0.04124044,-0.010995272,0.012667412,0.0076812394,-0.012809531,-0.049894568,-0.09852303,0.105050996,-0.019793002,-0.0099967085,-0.019963697,-0.13655645,0.019986957,0.043520186,-0.023905091,0.01654672,0.00906844,0.067000106,-0.02127561,-0.034059413,-0.015660034,0.011565166,0.009425055,-0.016429624,-0.024559008,-0.06303392,-0.019325867,-0.0062305727,0.0019947372,0.0237377,0.018033557,0.015119411,-0.037515398,0.010348134,-0.079674795,-0.060276147,-0.018820124,-0.031623248,0.07224546,0.26129204,-0.0141367605 +4.2.1.161,"The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the introduction of hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin to generate bacterioruberin.",384,0.99999994,-0.10058916,-0.0023645528,-0.11958908,-0.0168027,0.016082024,0.06484673,-0.0993254,0.05187716,0.007761384,-0.041111212,0.023142483,-0.08736596,-0.005549031,0.031637743,-0.010485431,0.012336242,-0.08639661,0.023441244,-0.0627783,-0.08298978,-0.0034393654,-0.034800258,-0.0050454885,0.045288336,0.01097437,0.004937505,0.048304427,-0.023658844,0.004003607,-0.00922815,-0.0313734,-0.0012431502,0.1445838,-0.07853134,0.11527518,0.02466323,-0.024726471,-0.0912255,0.07473058,0.005130665,0.012650361,0.04139911,0.013507125,-0.009616433,-0.0014530539,0.05827,-0.01840856,0.05696229,0.037900664,-0.024357025,-0.10822311,-0.028436607,0.0048873792,-0.05479453,-0.0022657914,0.06581776,-0.00442508,-0.07738163,0.08494209,0.01605568,0.06338433,0.015524136,0.05606119,-0.03336357,-0.030101975,-0.11085451,0.0010082586,-0.03245912,0.060861148,-0.068439655,-0.03063834,-0.102865696,-0.0068901414,0.011037061,-0.016476756,0.007057773,0.0076150447,-0.044140503,-0.018005619,-0.07849259,0.038617484,-0.077168964,0.009887928,0.04944405,0.001368404,-0.045939468,0.042246994,0.0003182957,0.022311121,0.11201928,0.016834939,-0.027657662,-0.022376841,-0.07518155,-0.0907431,0.027509004,0.057247486,-0.06578965,0.0012905736,-0.008120868,-0.007775612,0.06573988,0.04529496,-0.08565011,-0.044193953,-0.04212813,-0.024855647,0.08716693,0.0591424,-0.013031824,0.049923804,0.002922543,0.04709747,-0.039412607,0.0018102126,0.0791554,0.005352578,-0.01515814,-0.050141376,0.041651335,0.065404534,-0.070603795,0.03679982,0.026728833,-0.052350618,0.062194426,-0.12824099,3.2591246e-33,0.113514386,0.014529536,-0.0027697694,0.02569877,0.019911727,-0.06939342,-0.08682407,0.0058348062,-0.044929456,-0.14945915,-0.10661643,-0.017586945,0.039510995,-0.050848078,-0.0682889,-0.0013239378,-0.04716622,-0.042050414,-0.00385229,0.013303972,0.010431546,0.04286518,-0.031606276,-0.007604556,0.081065945,0.038645666,0.023220092,0.03998559,0.022876864,-0.0064141015,0.058150444,-0.06262198,-0.07028716,0.01757677,0.16082016,-0.005277985,0.0124312965,-0.073624045,-0.100108415,0.08171954,-0.0076461975,0.033111773,-0.0048937346,0.039307076,0.044353385,-0.0020603572,0.031178115,0.06302537,0.09465566,0.063716196,-0.010196111,0.025121069,0.07799207,-0.05411697,-0.02898909,0.053568006,-0.007921195,-0.019964049,0.062046256,0.015815241,-0.0070603485,0.089501835,-0.023562105,0.0341187,0.011401266,0.0067467303,-0.054387007,-0.04028617,0.0350954,0.018579865,-0.058679476,-0.023117006,0.025827687,0.044797286,0.049420882,-0.009167392,-0.047765225,-0.018277375,0.020995423,-0.11868572,-0.02102398,0.025083141,0.09456952,-0.012923492,-0.0084908595,0.035880875,-0.06546244,-0.045292985,-0.0071779992,0.040500138,-0.0108394865,-0.069714256,0.0042100414,0.041567806,0.00053910277,-3.8240705e-33,0.09470929,-0.12862726,-0.011392037,-0.03515266,-0.074126855,0.050796665,-0.01399562,-0.10296669,-0.018916184,-0.03256896,0.075484,0.019943291,0.13415924,-0.02231132,0.0031580091,0.029461026,0.1299252,0.059433654,-0.09220917,0.019944951,0.05363238,0.039669327,0.026607864,0.011525434,-0.016608454,0.038146276,-0.018309675,0.003700107,0.045070972,0.03219081,-0.0076338737,0.0036428112,-0.03789398,-0.10688635,-0.043426726,0.04683988,-0.06604644,0.0030326545,-0.002918262,0.012568486,-0.050736528,0.030809946,0.008724572,0.037946332,0.016680399,0.021013258,0.0059811124,0.019453764,0.022358237,0.0014072206,-0.010421596,-0.09192023,0.038893927,0.014754413,-0.002345762,-0.02778087,0.059997972,0.04469093,0.004122942,-0.0067560906,0.009776381,-0.08214579,0.06710689,-0.045798775,0.05231028,0.030182464,-0.025300251,0.0755487,0.08405644,-0.09420229,0.042373955,-0.002651881,0.06880343,0.06049064,-0.027632196,0.0197846,-0.021432908,-0.053872578,0.022280278,-0.039603695,-0.015204718,0.068395756,0.004868732,-0.05034496,-0.078101024,-0.088364705,0.038136814,0.034561407,-0.0038947815,0.010104386,-0.026778925,0.012841839,-0.04166261,0.015222937,0.062618606,-3.412674e-08,-0.0100011155,-0.016944667,0.0341771,-0.06285506,0.0766965,-0.012294786,-0.039372846,-0.008126101,0.0768916,-0.08434613,-0.036253665,0.053966094,0.07108447,-0.0095913615,-0.0071999445,0.06409885,-0.0007009441,-0.007425309,-0.0058493447,0.06420388,-0.041287594,-0.0065182103,-0.08107646,0.01162218,0.011151083,-0.05462615,0.0014751134,0.0081999935,0.0060366113,-0.037094127,-0.019676365,-0.0016750477,0.02231297,-0.018940585,-0.039668284,0.061180454,-0.022448577,-0.021245377,-0.06618411,-0.035408244,0.031744614,-0.049979176,-0.06670871,0.03133978,-0.036856245,0.0038421345,-0.007109657,0.06562054,-0.06415954,0.008566202,0.06857459,-0.06965743,0.042128958,-0.019185213,-0.0597162,-0.0064854,0.06729327,-0.059539437,-0.00085880945,-0.0012362347,0.0032127178,0.027344756,0.14309388,0.0025840665 +4.2.2.26,"The enzyme degrades unsaturated oligosaccharides produced by the action of alginate lyases (EC 4.2.2.3 and EC 4.2.2.11) on alginate, by repeatedly removing the unsaturated residue from the non-reducing end until only unsaturated monosaccharides are left. The enzyme catalyses a beta-elimination reaction, generating a new unsaturated non-reducing end after removal of the pre-existing one.",384,0.99999994,-0.033949073,-0.042451605,-0.0027883076,0.053773157,0.030297501,0.032678742,-0.07628997,-0.036142908,0.057102133,0.06325698,0.046970077,0.035562325,-0.052385587,-0.058743745,-0.09073495,0.058930952,0.00034061272,-0.004931155,-0.035629317,-0.05584797,0.11934608,0.005409473,0.0114171505,0.006786275,0.07943168,-0.07671783,-0.006646615,-0.06752101,0.0024088563,-0.102623664,0.009356661,-0.009418164,0.02842198,-0.04085456,-0.006658334,0.026642315,-0.014682948,-0.09098276,0.024613613,-0.003217187,0.08277032,-0.024461668,-0.03706064,-0.044918954,-0.06469645,-0.005258305,-0.011353324,0.035395615,0.00094616,-0.07606039,-0.019309606,-0.11823866,-0.07307118,0.039870363,0.042286057,-0.020705547,-0.07896296,-0.017353952,0.008010546,0.08238616,0.040555283,0.085831955,-0.04229369,0.018447882,-0.030117288,-0.06871517,0.068361335,-0.034668118,-0.0042005195,0.07272532,-0.05745568,-0.027439881,-0.011967449,-0.009013871,0.07811125,-0.005195588,-0.00503738,-0.10238587,-0.03478671,0.09080815,-0.0029443214,-0.038837977,0.03988871,0.039143957,-0.00388596,-0.09106918,0.0054904683,-0.019020418,0.098739855,-0.012450498,0.0062022167,0.0075621214,-0.01683532,0.01203464,-0.08409518,-0.03580607,0.06278601,0.026374644,0.026674831,0.033005696,-0.01793123,0.020314308,0.017695975,-0.1375629,-0.02192165,0.09908848,0.06757751,0.08284786,0.030699968,0.027624767,0.04035043,-0.05730009,0.0049156225,0.01301786,-0.132893,0.0695332,0.06282471,-0.09666154,-0.085140675,-0.022587106,-0.0083754985,-0.033840526,0.07999318,0.0777219,-0.08827543,0.06484435,-0.032583576,2.4451351e-33,0.008481325,-0.010430489,0.007812601,-0.0638899,0.04232772,0.0011256648,-0.06646309,0.007822178,0.0037434215,-0.023844164,-0.052073866,-0.0359504,-0.021724071,0.054503154,0.04466132,-0.03699175,0.055417813,-0.02284758,0.07748558,0.03112202,-0.027374191,0.044055253,-0.06882018,-0.0071093864,0.042223882,0.060015533,0.0035502792,-0.018659161,-0.0031599705,-0.0042626085,0.05469494,-0.011124968,-0.10297697,0.024479082,0.020735063,0.041156683,-0.040543538,-0.045327887,0.04171564,-0.023119092,0.023363562,0.07836966,0.043144472,-0.06094029,0.03991925,-0.06566331,0.0037559767,0.05414459,0.059277132,0.09213926,0.06100052,0.015077912,0.04027536,0.014587113,-0.098924935,0.053513967,-0.02334362,-0.019073403,0.01998231,0.07750433,-0.029157719,-0.018881291,-0.009818265,-0.04852074,-0.036501996,0.036125183,-0.02964868,-0.059090573,-0.04982105,-0.03411464,-0.12873635,-0.06560477,0.08415232,0.03256238,0.013004893,-0.05829628,-0.04152749,0.026331585,0.03839921,-0.04096499,0.062056407,0.004607253,-0.011186046,-0.009718682,-0.018079713,-0.010656885,-0.026623037,0.0226997,0.035436913,0.031415153,0.021511674,0.0077006477,-0.03389293,0.078165926,0.043443006,-3.673046e-33,0.10208488,-0.08284819,0.0047183526,-0.04223357,-0.075490244,0.0033097016,0.025299566,0.008534938,-0.012143898,-0.044501632,0.09042053,-0.030259911,0.04936147,-0.03276557,-0.0048550144,-0.014242482,-0.013679052,0.045220975,-0.060859673,-0.023341982,-0.010795231,0.13063295,0.06113761,-0.07184516,0.06783927,-0.034251045,0.039593033,0.06865464,0.043479625,0.05808262,0.003075769,-0.06226023,-0.041205395,-0.060231097,-0.04540884,0.045543958,-0.053457115,0.0039476072,0.02101927,0.04618328,0.09092714,0.021238092,-0.015308272,0.03002297,0.045952648,0.082238376,-0.07505364,0.040576637,0.041051213,-0.12158841,0.026760388,0.010321012,0.008921103,0.056267098,0.030169014,0.047038727,0.036368866,-0.006907938,-0.015524138,-0.06544742,-0.04537591,0.008500815,0.0869501,-0.06498326,0.04823495,0.004711847,-0.038772076,0.03669581,0.030234376,-0.020641979,0.047871288,0.03166828,-0.061262462,-0.039848078,0.031969525,-0.001626175,-0.12434894,-0.09074043,-0.06810566,-0.06506955,-0.021303486,0.006504513,0.040360637,-0.06519403,0.0024382488,-0.080992766,0.046992235,0.10443319,-0.041366972,0.101572156,0.011749591,-0.03257885,0.018069116,0.09586438,0.053305592,-3.779817e-08,-0.038282823,0.0058148103,-0.03191073,-0.03544126,-0.019982466,0.019415567,0.0016575265,0.038540047,0.021971678,-0.013681217,-0.027693143,0.098480046,-0.011448519,0.052882135,0.007725437,0.052014694,-0.0059269993,0.05121409,-0.0074777845,-0.010661371,-0.07916048,-0.011073298,-0.103620104,0.037754636,-0.022521911,-0.0005104773,0.07455509,0.080505475,-0.06554481,-0.0053750584,0.025685236,0.099037856,0.013192787,-0.04085741,-0.008103692,0.021182213,-0.06015013,0.009955074,-0.03690594,0.009669962,-0.027238173,0.033640623,-0.051433977,0.0018320533,-0.008838112,0.0035530152,0.057879794,0.062393118,-0.020568583,0.07865749,0.096744925,-0.046271976,-0.06414296,-0.060372595,-0.066623926,-0.06367104,0.00016952961,-0.025193326,-0.045578066,-0.030602336,0.05397257,-0.04664754,0.10939138,-0.025050253 +4.2.3.153,"The enzyme catalyses the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran. The sequence of events starts with the removal of a phosphate group, followed by aldol condensation and cyclization. Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea.",384,1.0,-0.07488298,0.020898106,-0.071532026,0.005588069,0.03135609,0.017147161,-0.06340834,-0.0055939183,0.03380597,0.003066038,-0.004134696,-0.03420494,-0.04993509,-0.023755744,-0.07718167,0.035528917,-0.07823729,-0.00757646,0.018889956,-0.04562252,0.13945603,0.09093874,-0.020415882,0.014627037,0.002791577,0.01114253,0.0326343,0.0051338966,-0.00035366288,0.015440515,0.023652842,-0.010523581,0.045275297,-0.0580883,0.036788374,0.12328347,0.04947581,-0.017858239,0.055298712,0.019458069,0.041079577,-0.04440797,0.05289382,-0.0027471376,-0.001253099,-0.03413388,0.005745801,0.031262707,0.008327642,-0.12472395,-0.10887003,-0.076680325,-0.085934125,0.0031456214,0.055668097,0.026813386,-0.02518651,-0.00255141,0.012859058,-0.024747454,0.059483122,0.029567681,-0.07706986,0.015099021,0.054849908,-0.067160055,0.044467337,-0.09566467,0.08138688,0.013562657,-0.026533358,0.0146077685,-0.007929087,-0.15104252,-0.0451806,-0.01684623,-0.012114613,-0.045493133,0.013922936,-0.030163491,0.08664883,0.036953464,0.026126694,-0.008965249,0.0004342404,-0.035597775,-0.025104426,-0.030636938,0.051700532,0.008432701,-0.048266217,-0.028479137,0.054127537,-0.026363362,-0.10949751,0.0025176469,0.102341756,0.030296564,0.05460265,0.06519918,-0.010023352,0.013717683,-0.056330375,-0.078863814,-0.09222847,-0.005565803,-0.006668767,0.09963837,0.04142989,0.06633724,-0.01284865,0.022130398,-0.005691419,0.066716,-0.031973593,0.14900608,-0.0024488098,-0.09622062,-0.007912498,-0.03249602,0.0037086664,-0.060656074,0.0598613,-0.0058088074,-0.07556229,0.016485346,-0.081929915,2.326075e-33,0.13670465,-0.0040141246,-0.0093763,-0.0314083,0.0004969977,-0.06210032,-0.07118189,-0.032556444,-0.0014117466,-0.012903986,-0.0378522,-0.078827225,0.04479638,0.026020585,-0.07596061,-0.099404834,-0.024752352,0.0043051336,0.036352325,0.05628647,-0.043646827,0.06698963,-0.060096245,0.025591983,-0.011200568,0.012415524,-0.057913467,0.020212678,0.0333184,0.020583501,0.041374046,-0.056218285,-0.116972655,0.014313494,0.058409438,-0.0025227617,-0.11256479,-0.04825672,0.022095045,0.015316437,0.031709574,-0.013001855,0.013085323,-0.031548828,0.05695049,0.046775024,-0.028581424,0.11834272,0.04001749,0.06323548,-0.00458337,0.025530871,0.06927261,-0.008295693,-0.074812725,0.007595768,0.026073586,-0.076300606,0.005022916,0.048917707,-0.03485367,7.010914e-05,0.008214021,0.04860695,-0.042189132,-0.029609853,-0.011149955,-0.053660095,0.085071385,0.089580305,-0.02986486,0.026638946,0.01722106,0.07931117,0.041995194,-0.030480009,0.03841125,-9.0457055e-05,-0.018014267,0.040271882,0.06889097,0.027060391,0.004175091,-0.071148604,-0.032330655,0.06654634,-0.047753062,-0.06868719,-0.007919684,0.024706168,-0.043163225,-0.086990245,-0.008914555,0.03318809,0.022499688,-3.6891402e-33,0.092494994,-0.047306657,0.055910707,-0.11352751,-0.105561644,0.025649846,0.018043404,-0.055574544,0.00442448,-0.008869685,0.083388925,-0.010188389,0.09492953,0.008465973,0.029853985,-0.013008727,0.020360917,0.048249833,0.0013961955,0.029442193,0.064660296,0.02784344,-0.06869421,-0.05809442,0.04600921,-0.026005339,-0.0009286555,0.072169766,0.0017678434,0.039865382,-0.027321631,-0.06606766,-0.06289578,-0.041576054,-0.10122462,0.051902704,-0.11223409,-0.015240195,-0.018057792,0.017674636,0.022972912,0.068836674,0.02122666,0.046822377,0.026257366,0.051654894,-0.07727401,-0.01999047,0.023486968,-0.06442014,0.027102547,0.004028001,-0.014488165,-0.022003692,0.025439382,0.08331559,0.0047747977,0.052913185,-0.0011256145,-0.048358556,-0.032236423,-0.06328392,0.07481551,-0.05744486,0.0809156,0.048852585,-0.0006377888,0.02386199,0.04439116,-0.004061567,0.033084504,0.07590242,0.030825974,0.045020416,-0.043415394,-0.068260156,-0.11508604,-0.0231344,-0.029736117,-0.004841138,0.040632155,0.01972756,0.042365793,-0.07857103,-0.028332625,-0.04058209,0.1111294,0.034220923,-0.032956697,0.046398748,-0.017900966,0.02224117,-0.0201901,0.042893812,0.04167918,-3.8169386e-08,-0.006356777,-0.08496529,0.07043432,-0.03144344,0.015092943,0.077012874,0.0603302,0.010402485,0.0513705,-0.040188666,-0.025864122,0.076575324,0.054295503,0.02726324,-0.024966167,0.01966771,-0.03544229,-0.030099541,-0.040596906,-0.050510507,-0.0373302,-0.021073727,-0.03178997,0.036268167,0.03802285,-0.05681299,0.049497988,0.12292833,-0.022482855,-0.039084688,-0.015757743,0.038135305,0.027480436,-0.063327834,-0.08746307,0.012426075,-0.062019918,-0.021006353,-0.014482413,-0.03346612,0.025545826,0.041356757,-0.02058337,0.08707296,0.00481374,-0.029645916,-0.04567556,0.07131544,-0.033981267,0.017291268,0.012431342,-0.0027154204,-0.0067408043,-0.06721576,-0.056623477,-0.04590237,-0.008533828,-0.006229152,-0.089289814,0.023216402,0.047135223,0.008689532,0.12310139,-0.039011717 +5.1.3.36,"The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC 5.1.3.17, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate.",384,1.0,-0.048487704,0.016549427,-0.059477195,-0.02641833,0.030149426,0.069706164,-0.058260757,0.012008469,-0.01930516,0.056597855,0.05083231,-0.03499612,-0.07333163,0.01726898,-0.11920875,0.007873974,0.0017277658,-0.02913813,-0.07971636,-0.076601826,0.09637668,-0.0009239285,0.026020741,-0.068515,0.04874054,-0.004280485,-0.047647227,-0.00762571,-0.0114116445,-0.08099525,-0.06877665,-0.07843888,0.050468598,0.020678198,0.037980404,0.14519744,-0.038451344,0.009924072,0.022484146,0.00025091882,0.016063485,-0.028550904,-0.06937207,0.027419867,0.0025244239,-0.10911538,-0.026292372,0.06128504,0.0070914775,0.049783535,-0.028263137,-0.05266945,0.0108059505,-0.02195838,-0.024460364,-0.0489894,0.0010541687,0.013370501,-0.030658666,-0.08037176,0.044905517,-0.0055362307,-0.04066765,-0.028178493,-0.01898216,-0.051849414,0.08066,-0.10971623,-0.068046495,0.028139062,0.023671463,-0.032474067,0.036925927,0.018068114,0.01788541,0.056326155,-0.017725805,-0.07945146,-0.004260935,0.0774828,0.039290708,0.083576314,0.07119186,0.0701884,0.029310444,0.0070708375,-0.02849235,-0.004536536,-0.055319477,0.021943409,0.046178427,-0.08437001,0.029188303,-0.022324074,-0.05635336,0.018323353,-0.018290352,0.102430224,0.017647473,-0.023120765,-0.014160811,0.004334944,-0.041473582,-0.09659334,-0.03920161,0.028141262,-0.013549161,0.059128243,0.088295326,0.001358572,-0.111922726,-0.02404643,0.007354026,0.013840545,-0.0775886,0.11738108,-0.078782044,-0.06060878,-0.03204995,0.018600147,0.005831338,-0.0326398,0.041061614,0.111458674,-0.01694112,-0.022569042,-0.06738824,1.4981331e-33,0.10141784,-0.0054490482,0.043716516,-0.03336532,0.0454512,0.0070070457,-0.068287395,0.061086047,-0.013611029,-0.044436555,-0.10161622,0.01426576,0.017503558,0.00069587893,-0.063509904,0.013087478,-0.0089497715,-0.020900145,0.07211038,-0.038928304,0.08717065,-0.041648313,-0.08422487,-0.025970876,-0.038907718,0.020112086,0.0010602043,0.070894726,0.051740285,0.019622149,-0.04547278,-0.1079885,0.0022134662,-0.0077395006,0.013947266,-0.043785576,-0.023861408,-0.01259872,-0.028644903,-0.015585118,0.0890896,0.047457002,0.018302422,-0.044533677,0.07836715,-0.052936703,-0.059870984,0.10875561,0.008924626,0.080552556,0.061463695,0.03590971,0.10451262,0.07231999,0.0066759996,0.09259961,-0.059326958,-0.041778073,0.026566016,0.010984107,0.031190172,0.004509511,-0.019087937,-0.04515715,-0.0016616249,0.05400909,-0.031226886,0.01488641,0.03260989,0.06525588,-0.04809403,-0.02304344,0.00011464659,0.086880125,-0.017981503,-0.032670803,0.031459417,0.028284809,-0.04362157,-0.0013516676,-0.026418297,-0.035976253,-0.028585874,-0.048440248,-0.123599865,0.007514198,0.025678447,-0.047893874,0.007868643,-0.05275308,0.025792928,-0.07819688,-0.08977707,0.011903397,0.0057296497,-2.6728655e-33,0.0763533,-0.096405864,0.046797555,-0.019032424,-0.044329066,0.038533952,0.020450052,0.033314016,0.06705212,-0.0063463105,0.0143974135,-0.039297048,0.08252391,-0.05172994,0.033189636,0.07675722,-0.013267084,0.03701985,0.01260891,0.029716006,-0.11108342,0.056633484,0.07103805,0.016822994,0.002160561,0.009136711,0.020749023,0.024308031,-0.0076200506,0.12492696,-0.036094707,0.03330237,-0.041536316,0.033744115,-0.05810086,-0.026376681,-0.04747254,-0.0387299,0.01874789,0.039705515,0.10904151,0.0041173752,0.012410412,0.05422733,0.07230261,0.09659655,-0.072345786,0.10625842,-0.0024822822,-0.098682694,0.050569225,0.0656409,0.028183071,0.019436918,0.123898484,0.0739159,0.031102117,0.013574483,-0.023758626,-0.038486592,0.0018363161,-0.037575282,0.0074163508,0.013706487,0.026319398,0.0508828,-0.03399056,0.039818674,0.0060060015,0.07354293,0.013568415,-0.028258095,-0.02454773,0.034948356,-0.02171817,-0.017727034,-0.0634664,0.0063894223,-0.044640638,0.018652128,-0.026648393,0.042462714,0.018824134,-0.07693297,-0.012751988,0.012047697,0.0041218787,0.096856676,-0.023864506,0.08515418,-0.048070382,0.009706188,-0.062106658,0.06032623,0.065761134,-3.7561893e-08,0.07576466,0.033042636,0.110131785,-0.024672078,-0.022785835,0.0033743102,-0.020869175,0.004081238,0.011042786,0.036146294,-0.017449835,0.073007666,-0.005587498,0.008259621,0.011335597,0.003010682,0.021727119,0.02946454,-0.017296897,-0.030934872,-0.13769934,0.029159792,-0.0063995635,-0.006594987,-0.02763631,-0.02469663,0.056885976,0.019901764,-0.045264486,0.0016765378,-0.06538164,0.048400916,-0.026953688,-0.10826682,-0.08728543,0.069759026,0.008092691,-0.057659477,-0.062179744,0.014875708,0.033228528,-0.013840465,-0.0024665396,0.008341298,-0.0079438,-0.027358139,0.118360594,0.023563093,-0.02300374,-0.024179112,-0.01348161,0.0077672806,-0.059486274,-0.08283724,-0.080746986,-0.011049857,-0.034338307,-0.057666633,-0.0013804275,-0.017397776,0.016601218,-0.05156132,0.10880447,-0.050806265 +5.1.3.37,"The enzyme epimerizes the C-5 bond in some beta-D-mannuronate residues in mannuronan, converting them to alpha-L-guluronate residues, and thus modifying the mannuronan into alginate. It is found in brown algae and alginate-producing bacterial species from the Pseudomonas and Azotobacter genera.",384,1.0,-0.039352804,-0.034411155,-0.030407017,-0.072325945,-0.009533781,0.06612081,-0.013831388,-0.023568232,0.011812821,0.12685116,0.0924257,-0.06396117,-0.06546662,0.011920028,-0.14993027,0.027315658,-0.085189834,0.04505968,-0.032006055,0.058405247,0.12018724,0.07144134,0.029836392,0.0023423093,0.07340864,-0.010808441,0.01594286,-0.053007998,-0.008916851,-0.07294012,-0.046466306,0.02094533,-0.0032088193,-0.043177724,0.10806727,0.06846044,-0.01718943,-0.06771918,0.16141988,-0.025544098,0.06347334,-0.055681776,0.010398117,0.03499925,-0.01987496,0.029677667,-0.011160125,0.11490709,-0.0020087408,-0.043726835,-0.022118151,-0.06442089,-0.0001035205,-0.021023387,-0.00795189,0.014748757,-0.0014037858,-0.002223833,0.011461575,0.035567738,0.05169793,0.010047898,0.06903618,-0.023309354,-0.0513802,-0.042733233,0.027067462,-0.06505385,0.028653016,-0.0028720365,0.006473126,-0.05790257,0.009253811,0.0010257461,0.03357184,0.0058501074,0.05109781,-0.14640544,-0.034659848,0.006892781,-0.010061854,0.011667137,0.101538554,0.033685036,-0.002225453,-0.0753089,0.033156507,0.032129288,0.04933467,0.011112735,-0.0005574265,0.013718471,-0.058127943,-0.08251543,-0.10598269,-0.014717709,-0.021399701,0.045608845,0.06786945,-0.014168021,0.010749785,0.029836264,0.021587275,-0.15341984,-0.013069742,0.009993735,0.045417607,0.011815291,-0.02128622,-0.034562904,0.0075802044,0.02570103,-0.05289103,-0.024913037,-0.058074135,0.034125067,0.04945316,-0.102150485,-0.06873652,-0.00075665716,-0.0783019,-0.04577409,-0.0067032585,0.039835576,-0.06410684,-0.024688851,-0.10147426,9.136594e-34,0.015007031,-0.056397095,0.015698833,-0.03998843,0.10324981,0.045628533,-0.047181394,-0.10224508,-0.040519573,-0.09573724,-0.11394789,-0.08893766,-0.026651913,0.042576768,-0.020278176,0.079518065,-0.0804941,-0.017503032,-0.0064595174,-0.027313748,-0.022379396,0.077724546,-0.06518372,-0.012979628,0.09403804,0.08365598,0.021253629,-0.010446188,0.06335429,-0.015843967,0.06299631,-0.024195667,-0.10352411,-0.04498024,0.07479401,0.08043929,0.0016673936,0.04515516,0.025635753,0.03595324,0.054223064,0.044685375,0.021690372,-0.0022119165,0.055523854,-0.00030255187,-0.00961288,0.1126102,0.041116465,-0.0026028883,0.025258599,0.024841271,0.01769696,0.024789296,-0.06826984,0.052863706,-0.03815071,-0.0030080888,0.06428817,0.09525755,0.020626225,-0.005341442,0.0027893975,0.0031569574,-0.004822679,0.05139673,0.024918295,0.01750039,0.07115086,-0.0069050924,-0.1100658,-0.061571334,0.08064565,0.02047463,-0.032252714,-0.024650818,-0.044735804,-0.031453714,-0.013448552,-0.0028957448,0.035494942,-0.04110679,-0.012363778,-0.036821254,-0.08503014,6.575911e-05,-0.04837147,-0.019044528,0.045192182,0.023916349,0.05704359,-0.033789624,-0.063502245,-0.006159927,-0.06399204,-2.7730323e-33,0.10918657,-0.10898357,0.10034442,-0.008719803,-0.06517455,0.025797905,-0.020052416,-0.020454299,-0.020314157,-0.036500745,0.08935099,0.001182513,0.020165024,0.006437934,-0.017416261,0.008584447,0.012930505,0.071359776,0.0012924547,0.0050010127,0.0075066127,0.06897407,0.025270874,-0.009202376,0.029377688,0.022094559,-0.06497849,0.022895992,-0.003952237,0.08158569,-0.04336435,-0.026017446,-0.050095115,-0.093468934,-0.04630103,-0.012710095,-0.018808682,0.0009922825,-0.027787142,0.042784333,0.017819604,-2.2910295e-05,0.012371584,0.021934882,0.018414881,0.09069495,-0.019879006,0.00387715,-0.08592227,-0.030379334,0.06010881,-0.00965395,0.04309472,-0.03070903,0.016857004,0.04140913,0.0061328434,0.014781873,-0.020744283,0.03710763,-0.044226,-0.06504807,0.07770334,-0.03580317,0.047959335,0.028473316,-0.023789085,0.06145964,0.047871258,-0.04432009,0.014563199,0.0941855,0.010834412,0.05304977,-0.031141408,0.017594367,-0.08051768,-0.08939031,0.026941454,-0.06831412,-0.0039571044,-0.0022259327,-0.03070504,0.0065204855,0.0069652325,0.0090081105,0.08575553,0.12584823,-0.046144,0.06836786,-0.077136196,0.0101461,-0.056832056,0.07747283,0.016183773,-3.4080852e-08,0.008239341,0.04086977,0.08320481,-0.038505428,0.041368358,0.027474979,-0.011522105,0.06307416,0.05979077,-0.027167527,-0.026114164,0.07726441,-0.010956325,0.018812548,0.018118039,-0.021430671,-0.031102605,0.0037087197,-0.0277706,-0.027595676,-0.10614577,0.041703623,-0.047532286,0.01523563,-0.0078117736,0.029820072,0.041769844,0.074799456,-0.08771247,0.020941913,0.010681133,0.06583989,0.029861348,-0.04979074,0.007822445,0.04653722,-0.08219688,-0.07065378,-0.050952237,-0.012278491,-0.0304196,-0.039627727,-0.0010211036,-0.03263627,-0.03200416,0.0023980346,0.023608727,0.050319873,0.0013240479,0.0277874,0.07911705,0.0034124502,-0.013012872,-0.048390865,-0.096098885,-0.00022682916,0.0021963862,-0.06589958,-0.0053690947,-0.011549164,-0.0029045597,-0.09086404,0.06934574,-0.026621612 +5.1.99.8,"The enzyme, which has been characterized in bacteria and plants, also has the activity of EC 4.1.2.25, dihydroneopterin aldolase. The enzyme from the bacterium Mycobacterium tuberculosis has an additional oxygenase function (EC 1.13.11.81, 7,8-dihydroneopterin oxygenase) [4].",384,0.99999994,-0.05232982,-0.020401528,-0.020712892,-0.014971314,0.06708828,0.024578998,-0.039618023,0.066743605,0.024110733,0.007795101,-0.0070390096,-0.06593183,-0.0047145495,0.07141206,-0.044315338,0.08148111,-0.05064742,-0.009901398,-0.022997117,-0.06426356,0.026212107,0.08790643,0.03808871,-0.022900013,0.059692595,-0.014277925,0.027363256,0.0049339547,-0.04057121,-0.075800285,0.008620349,-0.11180865,0.10807719,-0.06820323,0.0367426,0.084435254,-0.021062944,-0.15157616,0.05696801,0.08100735,0.052347597,0.017151872,-0.010744542,0.0050364016,0.017098898,0.0076225065,0.008196694,0.031771567,0.034067832,0.017915733,-0.036408722,-0.031286236,-0.07135588,0.024792973,0.031852596,-0.022572426,-0.05333273,0.022704024,0.010423535,0.018535947,0.085170746,0.0028566278,0.05623212,0.026969127,-0.0030449072,0.00875605,-0.008207513,-0.07144567,-0.026018916,-0.083206765,-0.07679884,-0.06601553,-0.047506012,0.03022756,-0.019565202,-0.030506657,-0.032019693,-0.043787543,0.008605148,0.032520592,0.01743668,-0.021515988,-0.025122728,-0.007981585,0.036816917,0.0014649928,0.045662068,-0.02446548,0.013872386,0.005474674,0.043151546,-0.07316704,-0.056156717,-0.031019686,-0.018657327,-0.020311387,0.032872137,0.074030384,-0.00082974957,-0.025736228,-0.017189218,0.06679881,-0.073553555,-0.08308801,-0.056945127,0.01220111,0.016164625,0.045249224,0.033436075,0.0059599834,-0.0016090515,-0.04601611,0.029055087,0.0068330425,0.025421552,0.07742137,0.03902437,-0.06593772,-0.06081845,0.027257163,0.045945663,-0.09374025,0.11676359,0.053718403,-0.04397476,0.069484666,-0.1204986,-4.6674757e-34,0.07235327,-0.047128983,0.022475334,-0.016845236,0.035905287,0.019585317,-0.07792611,0.05843,-0.094830535,-0.09728549,-0.085346706,0.0046824133,0.08860684,0.020402856,-0.04786438,0.015618491,0.02292433,-0.0049351924,0.08561595,0.055109654,0.05661059,0.011626634,-0.023162527,0.10641183,0.08114145,0.019984812,0.005375583,0.0031414712,0.05607628,-0.017964989,-0.017942762,-0.11067764,-0.13262068,-0.023426617,-0.007219677,-0.021286009,-0.048085015,-0.0056200647,0.024288226,0.012001433,-0.036255796,0.04354115,0.042191055,-0.07778982,0.07679839,0.011584906,0.001000676,0.07277775,0.0314076,0.02334114,0.0041847713,-0.040483307,0.10184399,-0.031815328,-0.0069860173,0.026751835,-0.035933003,0.084498495,0.043784708,0.047547996,0.03310987,0.07412747,-0.0358643,0.041262433,-0.035680115,0.021311786,-0.057771288,-0.0131660765,0.061045203,0.054985583,-0.03324517,-0.02793392,0.0008948714,-0.060149413,0.051192027,-0.048403155,-0.09795514,-0.0491735,-0.02145,-0.0031179765,0.040181816,-0.011339854,0.060893334,-0.022550203,-0.028371803,-0.05602075,-0.044960503,0.01819914,-0.007458014,0.0101985885,0.032494437,-0.026369218,-0.0991652,0.008754816,0.017850174,1.0621545e-34,0.12869258,-0.10692367,0.055112608,-0.056843404,-0.011480119,0.060128383,0.0061100964,0.009848302,0.037084315,-0.011416741,0.13017236,-0.008039568,0.016343486,-0.051192872,0.0227235,0.023296447,-0.10429793,0.051922858,-0.022184253,0.037676305,-0.020423671,0.052091926,0.033333525,-0.074354604,0.03922821,0.021153241,-0.03971086,0.027743395,0.09045825,-0.022448558,-0.099615104,0.038875997,-0.026458329,-0.0037871173,-0.08298425,0.014769723,-0.04486737,-0.04599388,0.052829396,0.024711365,0.05259131,0.06477694,0.045070857,0.049224406,0.032149743,0.052730523,-0.04181998,0.017853511,-0.03629921,-0.01543116,0.008610428,-0.031712078,-0.056815267,0.030932358,0.051354997,0.034275725,0.029519668,0.055107117,-0.027560236,-0.018930268,-0.02708394,-0.04961484,0.07258872,0.033804033,-0.006010611,0.071466126,-0.031037785,0.07646109,0.04742402,0.0062172897,0.06763679,-0.0690036,-0.006024595,0.02696927,0.0030467228,0.012283616,-0.05771246,-0.0035758906,-0.0001654422,-0.0010374665,-0.052809555,-0.0030324596,0.006034964,-0.10284208,-0.00864255,-0.046242774,0.035846196,0.09142106,-0.03368361,0.08725579,-0.026355483,0.0031678178,-0.07523839,0.036946215,0.061602417,-3.691313e-08,-0.017616758,-0.041989293,0.11117135,-0.032958247,0.053130448,0.0075922697,0.075594656,0.056287054,0.04067433,-0.003117047,0.043345593,0.020688882,0.02508546,-0.048533116,0.103382826,-0.015936743,0.007840569,-0.018724466,-0.018932885,0.022637634,0.0006473141,-0.027276272,-0.07455654,0.059924155,-0.032087248,-0.09655321,-0.037723947,0.030625295,-0.022769352,-0.013247741,-0.04606584,0.036270265,0.034002107,-0.112285286,-0.13192682,-0.028463928,-0.0369851,-0.029369105,-0.056797028,0.032995403,0.010147124,-0.12567073,-0.068829626,-0.010075719,0.026095195,0.02470516,0.048934124,-0.026659321,0.009433677,-0.019037744,0.05795829,-0.04182723,0.00051181024,-0.04010505,-0.081887946,0.08058198,-0.016809218,-0.050849643,-0.02516393,-0.05520141,0.006730036,-0.0054147104,0.1804549,-0.045058075 +6.3.1.19,"The enzyme has been characterized from the bacteria Mycobacterium tuberculosis and Corynebacterium glutamicum. It catalyses the ligation of the prokaryotic ubiquitin-like protein (Pup) to a target protein by forming a bond between an epsilon-amino group of a lysine residue of the target protein and the gamma-carboxylate of the C-terminal glutamate of the ubiquitin-like protein (Pup). The attachment of Pup, also known as Pupylation, marks proteins for proteasomal degradation.",384,1.0,-0.07444748,-0.020816656,-0.06995931,0.023464235,0.023128962,0.04804329,0.02574773,0.07304756,0.013393348,-0.018653119,0.037462216,-0.012159537,0.07045613,0.06358745,-0.06436263,0.010276331,-0.049865607,-0.012435856,0.0026755882,-0.07825752,0.009848897,0.0908615,-0.034983106,-0.046751417,0.06875985,-0.031815037,0.06735521,-0.024500154,0.029457223,-0.096377894,0.0021065644,-0.09617859,-0.0028341783,-0.03301175,0.08340366,0.06753357,-0.06192333,-0.119767755,0.05738202,-0.060761143,0.06995582,0.025975432,0.008762711,-0.01465352,-0.014401396,0.04615053,-0.042952545,0.043703664,0.08291363,0.0730662,-0.029788446,-0.040173795,0.0025125698,0.061679427,0.035676267,-0.012766077,-0.04265884,-0.007062286,0.03136299,0.034325436,-0.005042919,0.054349814,0.04426227,-0.008474094,0.044042867,-0.035322998,-0.028207991,-0.02008525,0.043838818,0.021624416,-0.037228983,-0.039614644,-0.020887114,0.08451749,-0.020326586,-0.00030042639,-0.06457211,-0.005467465,-0.024124412,0.027585754,-0.0069934097,-0.013567452,0.08158051,0.042861708,0.013962303,-0.0017072099,0.04924967,-0.047269553,0.030157955,0.0118330205,0.047962602,-0.018425249,0.006149977,0.0067509,-0.10081795,-0.0062974496,0.026260318,-0.018149557,-0.03802427,0.004959383,-0.022007978,-0.0068199704,-0.0034808484,-0.09575805,-0.008382001,0.027329182,-0.031247167,0.07749174,0.10302361,0.0097942315,-0.03169212,-0.010520185,0.007343321,-0.013190686,-0.027511157,0.008085994,0.025103666,-0.03164552,-0.06477675,-0.015763804,-0.006191118,0.008955127,-0.036922406,0.041482072,-0.04979072,-0.046118278,-0.11474659,1.9323357e-33,0.10031307,-0.057292998,-0.00074094435,0.028378218,-0.016890006,-0.02990901,-0.072361745,-0.02531874,-0.022984043,-0.088165626,-0.01334082,-0.05264532,0.022851096,0.0020527123,-0.0073796175,-0.012674917,-0.031222178,-0.024405932,0.11569771,0.098207355,-0.021401472,0.011282579,-0.0033583005,-0.013858502,0.031214103,0.06815299,0.0011100377,0.048139196,-0.00943405,0.008413209,-0.057446916,-0.03406211,-0.11513097,0.009091485,0.0035956407,-0.04352454,-0.012066629,-0.0667329,0.02197796,0.096312396,0.038413454,-0.017365618,-0.094746925,-0.026637988,0.109724425,-0.056120016,0.020071432,0.11748156,-0.051027156,0.0053682206,0.088281475,-0.061447084,0.096292175,-0.04562524,-0.1011238,0.06071834,-0.021983426,0.044807747,0.06167332,0.051863518,0.045372672,-0.026107963,-0.07020029,0.02043147,0.0054261326,-0.0077635297,-0.044135515,0.01107245,0.0076611186,0.0017348904,-0.05451389,-0.060246155,0.050266325,-0.019591345,-0.035033643,-0.050985754,-0.0866741,0.025383865,0.10057993,-0.016024834,-0.039090052,0.013352262,-0.07387115,-0.024332145,-0.01563479,-0.04314703,-0.0026834465,-0.06360189,-0.04306355,-0.018145755,0.03792219,-0.057000197,-0.04475412,0.10503515,-0.016984148,-3.749379e-33,0.12737358,-0.08437431,0.042484596,0.009248433,0.04856564,-0.029254744,0.06369379,0.010771122,-0.013237907,0.022377243,0.06395121,-0.03247746,-0.00096522266,-0.010947637,0.004415079,0.038812578,-0.008910676,0.03785091,-0.028587844,-0.025501125,-0.009665334,0.019614952,0.03546883,-0.09278444,-0.02316107,0.02569932,-0.033304464,0.04639217,0.04458584,0.055172414,-0.015563361,0.02922388,-0.04748606,-0.041393593,-0.09546189,0.035531987,-0.006485786,-0.030692838,0.11620656,-0.09539406,0.06326875,0.024836924,-0.05424975,-0.011860537,0.058514863,0.09027057,-0.038074385,-0.048843127,-0.032093346,-0.06262795,0.04645811,0.0056502423,-0.036371525,-0.012810901,-0.15067941,0.042000838,0.057983506,-0.008082135,0.059818313,0.05193314,-0.02079145,-0.00084801257,0.054690924,0.09263825,-0.022171138,0.05041123,0.062019378,0.043945525,0.060934786,-0.042206727,0.07791404,-0.025638338,0.06822333,0.038043566,0.006910669,0.007883142,-0.012841433,-0.010169117,0.016376166,-0.0619757,-0.068031795,-0.05426374,-0.056732602,-0.04294082,0.042086273,-0.036524754,-0.011684662,0.14346063,0.020407198,0.06518299,-0.047815677,-0.014610688,-0.035842028,0.06163667,0.066033654,-4.094802e-08,0.0013637678,-0.036765162,-0.0025425167,-0.01879871,0.057737846,0.049623985,-0.06927768,0.021854805,0.07153521,-0.03519068,0.011590132,-0.021148259,-0.09932854,-0.0153121995,0.027345672,0.059144195,-0.0049918666,0.015256768,0.00465527,0.014043511,-0.082990855,0.011075075,-0.032215264,0.06570557,-0.03158375,-0.064333655,0.044856034,0.08650377,-0.09517387,-0.045873128,-0.07136762,0.094020195,-0.050527707,-0.08363072,-0.060763206,0.0031643074,0.019843692,-0.061000645,0.04431165,0.05359466,0.023720518,0.035718285,-0.058933925,-0.031445198,0.05483593,0.050964985,0.04472344,0.04669736,-0.036513068,0.009538083,0.03654381,-0.077076465,-0.10766166,-0.058656372,-0.053490564,0.040695883,-0.029488765,-0.04759804,0.0008125651,-0.074790224,0.02190378,0.01608386,0.16722877,-0.050991118 +1.1.1.391,"This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.393, 3beta-hydroxycholanate 3-dehydrogenase (NADP+).",384,1.0,-0.043061595,-0.06438038,-0.09448613,-0.06020684,0.016541,0.058060303,-0.072091304,0.017064903,0.029251626,-0.0095713455,0.05583863,-0.024554018,-0.06604532,-0.0016792781,-0.032944538,0.024053482,-0.034113713,-0.0073614344,0.025322117,-0.05805445,0.016209159,0.012320627,0.028898407,-0.0135456,0.05281909,0.044469435,0.12095325,0.02604433,-0.06293814,-0.076964304,0.014930136,-0.034916263,0.079335004,-0.124014884,-0.010702689,0.046820804,-0.078684315,-0.04062877,0.0146956295,0.036662742,0.010420454,0.032287594,-0.044284828,-0.038921747,-0.026609452,-0.06437182,0.009496687,0.07754818,0.054429516,-0.045577973,-0.015957309,-0.00039863118,-0.01140143,0.020942254,0.050832048,-0.031822633,-0.004521616,-0.026055798,-0.037449956,-0.07991248,0.00047282517,-0.042005442,0.093568765,0.0059486865,0.060251314,-0.058778446,0.062256496,-0.10553923,-0.009241171,-0.074906774,-0.18144031,-0.04807144,0.018450592,0.035905935,-0.034691803,0.038651153,-0.045903265,-0.044722497,0.10949102,-0.031110466,-0.01915643,-0.04277748,-0.027737863,0.12672094,0.043264266,-0.058168024,0.007170957,-0.026586285,-0.029483981,0.023150397,-0.022996057,-0.042255875,-0.03917541,0.044036042,-0.09884856,0.002704193,0.0073529356,0.016987547,-0.009872723,-0.0610099,0.008325683,0.094338775,-0.010407511,-0.06061901,-0.04275017,0.00219453,0.008610422,0.10045162,-0.019822607,-0.008196763,0.020694045,-0.047219213,0.021179197,-0.077641204,-0.07468075,0.17355336,0.01756836,-0.068326,-0.048421778,0.011441327,0.021664616,-0.002264683,0.051800843,0.01581416,-0.03450843,0.022466483,-0.08932466,1.0503467e-33,0.069371246,0.019340245,-0.073656864,-0.06132737,0.043815356,0.012449906,-0.07904728,0.06627554,-0.01686373,-0.039807174,0.0026563702,-0.032500703,0.077914424,-0.013692087,-0.017615354,0.034236297,-0.013856145,-0.011855192,0.016022427,0.025713403,-0.023773758,0.06305228,0.015207551,-0.029298257,0.06766032,0.04098152,-0.056601644,0.021458605,-0.01617371,0.010087091,0.068096384,-0.066209175,-0.14221403,0.045285877,0.07222764,0.02898213,-0.034210067,-0.03622801,0.0024947834,0.085301176,0.005648272,0.020383267,0.014823892,-0.032810245,0.03578627,-0.041888926,-0.05536272,0.08625672,0.107061766,0.07205852,0.08530173,-0.0174169,0.11373854,-0.0813217,0.0069700205,0.014494823,-0.035836812,0.038491994,-0.009232128,0.03275573,0.0053764237,0.08645897,-0.05592712,0.07899643,-0.04914257,-0.01870137,-0.04382071,-0.027286155,0.03523376,-0.014352617,-0.05145072,0.041022368,0.083484314,0.013741294,-0.027631328,-0.011478823,-0.04836661,0.014774513,0.050829083,-0.03348518,-0.04801814,0.0072424277,0.028314339,-0.09412614,-0.029211653,0.09236595,-0.037234623,-0.021552183,-0.007721535,0.036133118,-0.00418393,0.013941358,-0.044663146,-0.0033738422,0.07087025,-3.874e-33,0.033249628,-0.059782337,-0.01496235,-0.14640199,-0.026429024,0.08717737,0.022782173,-0.06189867,0.011535662,-0.05394605,0.06631461,0.012545545,0.03876797,-0.03226299,0.054298934,-0.012030678,-0.025274964,0.0629152,-0.05758847,-0.07732578,0.062553756,0.09868202,0.03183794,0.014988115,-0.00899867,-0.0250285,0.0029186103,0.0026819035,0.04819092,0.06760924,0.007867733,0.030170357,-0.06290418,0.0112216845,-0.0031700288,0.017257594,-0.07445249,-0.017964486,0.011102148,0.007672614,0.015584639,0.0151562495,0.008635249,0.02326528,0.037842233,0.06991792,-0.03504556,0.0027587311,0.02877819,-0.06905151,0.013051239,0.011864085,-0.032482944,0.040380735,0.040908337,0.09411537,-0.03207615,0.008283444,0.07534627,-0.059438612,-0.046454296,-0.027162338,0.09782412,-0.0023210105,0.041630346,0.032298926,0.008056769,-0.044755764,0.039082807,-0.0070856796,0.049976517,0.035605725,-0.019847251,0.029345734,-0.014026887,-0.019565592,-0.06916239,0.01989972,-0.0023416241,-0.0659286,0.046327535,-0.0074432245,0.01454686,-0.04695361,0.017859442,-0.06533596,-0.07759824,0.09563541,-0.013886216,0.013119377,0.0007302329,0.051456593,-0.09213828,-0.025997622,-0.019690664,-3.8869793e-08,0.054843258,-0.06062754,-0.015575856,0.0090446025,0.04632506,0.04890743,-0.023643393,-0.03074358,0.056225255,-0.04275545,0.0048327916,0.18880667,0.036275014,0.006907549,0.02089167,-0.017075801,-0.033490524,-2.4455745e-05,0.0053638956,-0.05589852,-0.096970335,0.0036651327,-0.083885536,0.023522332,0.032216817,-0.033425618,0.002276252,-0.040091053,0.04753953,-0.03864632,0.02319271,0.0463446,0.03483535,-0.042228848,-0.026701204,0.004924679,-0.017607938,0.035996336,-0.014047049,0.08010409,0.012930413,-0.073359504,-0.06587711,-0.007432388,0.029945035,0.03083303,0.009156444,0.017252978,-0.10953423,-0.021546282,-0.032215748,-0.042359672,0.08233225,-0.00030969197,-0.06815363,0.025262164,0.00874275,-0.10491981,-0.033642147,0.023068696,0.012775917,-0.003942276,0.15612844,0.014740801 +1.1.1.392,"This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+).",384,0.99999994,-0.02399034,-0.09958134,-0.12750337,-0.039211858,-0.026141664,0.043649405,-0.07420556,-0.0015739442,0.017109247,0.00044379817,0.05352744,-0.051766086,-0.059664078,0.007532867,-0.011603998,0.03865623,-0.06933168,0.031648707,-0.011376036,-0.058032427,0.014966448,0.015640948,0.041980393,-0.02470406,0.035249583,0.0295223,0.14164412,0.013474243,-0.041287348,-0.07630076,0.019948635,-0.043542285,0.11277728,-0.093130305,-0.034266554,0.046857767,-0.07778331,-0.021621492,0.045460977,0.04758058,0.015271317,0.0115288645,-0.021455532,-0.068203636,-0.0403235,-0.052486606,0.008305527,0.058130965,0.08004907,-0.029814767,-0.031518243,-0.019247565,-0.032280806,0.031184169,0.026212372,0.0147377355,-0.0038927554,-0.036892667,-0.024655411,-0.07213265,0.04210165,-0.023920923,0.079393364,0.002911091,0.039444122,-0.07710284,0.031345736,-0.10765979,-0.0029804357,-0.08853531,-0.121043004,-0.0652165,-0.022822905,0.015023615,-0.028276403,0.019061968,-0.045160215,-0.013459327,0.05863303,-0.040498186,-0.02529079,-0.051031277,0.0072051357,0.14268078,0.03299964,-0.07320273,-0.012124776,-0.023508212,-0.00056620507,0.029908746,-0.029569624,-0.035892334,-0.024744682,-0.0134854,-0.04682146,-0.018791094,0.019512312,-0.002098469,0.049303,-0.025194412,0.016515866,0.07397015,-0.036761392,-0.093485795,-0.043020904,0.034759197,-0.020012438,0.08674025,0.0021011508,-0.0031022402,0.0069011147,-0.03621772,0.053281974,-0.07357801,-0.10121804,0.1788836,0.03888935,-0.09986103,-0.052021228,0.03488719,0.014256248,0.023569467,0.015234793,0.008426117,-0.027440583,0.022477463,-0.07142231,-4.9415624e-34,0.07832949,0.025215901,-0.056062214,-0.043437988,0.03824322,0.0058915387,-0.047792602,0.023425153,-0.013084619,-0.051132504,0.011401694,0.01413514,0.08093059,-0.0011321935,0.0028248068,0.042818528,0.010360067,0.017438589,0.059656095,0.033964474,-0.007682157,0.06045047,0.0102380505,-0.09133625,0.044356056,0.06364037,0.0014478825,-0.011820986,0.0049685044,0.018842041,0.054594148,-0.036580537,-0.08359452,0.02640267,0.08030224,-0.010185288,-0.055185385,-0.0060074897,-0.004299967,0.101687536,0.058422938,-0.020681499,-0.012178101,-0.03726109,0.02044867,-0.030616114,-0.01298064,0.086649604,0.10891064,0.09215578,0.07956061,-0.019198475,0.067733936,-0.067784585,0.012494493,-0.01343339,-0.027026692,0.027065473,0.015038556,0.022200167,-0.020175036,0.09069847,-0.083820164,0.10288367,-0.0572329,-0.038341757,-0.03564315,-0.029208189,-0.004397749,0.005777434,-0.08642495,0.017515812,0.037834156,-0.0015991653,-0.058247745,-0.005818599,-0.07788484,-0.015444513,0.07323228,-0.058506582,-0.043582,0.02437159,0.021905705,-0.083874494,-0.050907113,0.05607069,-0.04853818,-0.04498965,-0.0875242,0.0046961214,-0.031115146,0.0108071435,-0.066091076,0.02855136,0.1182769,-3.2025605e-33,0.03779528,-0.08369828,-0.017128365,-0.13725862,-0.02199995,0.07261488,0.009142496,-0.049737953,0.021312688,-0.009451982,0.021280456,0.00944573,0.05771091,-0.044488993,0.043409325,-0.007005792,0.01230362,0.06836066,-0.05098184,-0.0952343,0.08104932,0.10354333,0.03712008,0.020223893,-0.020117218,-0.011797045,-0.0044869785,0.03556882,0.046016164,0.11813868,-0.0051775263,-0.011988238,-0.0012514541,0.0051385667,-0.015432311,0.033847343,-0.04540853,-0.021090347,0.020242596,-0.011264192,0.00809225,0.0031439643,0.062335905,0.0396771,0.016364263,0.06561299,-0.033508204,0.021926403,0.023554683,-0.068089664,0.036165513,-0.026039686,0.0010087704,0.023698872,0.04581967,0.091378115,-0.06210788,-0.032612737,0.052798998,-0.07473772,-0.062065233,-0.04507965,0.12045757,-0.025039408,0.0049609668,0.053339552,-0.0072826897,-0.042589374,0.029294522,-0.0017438668,0.064285435,0.04874241,-0.014693516,0.040719368,-0.0034531285,-0.023418773,-0.08078444,-0.017103683,-0.004243769,-0.039480526,0.0047552283,-0.018183272,0.022548996,-0.062227346,0.031299524,-0.09561414,-0.07275018,0.10006267,-0.00453951,0.007124386,0.0004942785,0.021888515,-0.07028503,-0.0113040265,0.007406878,-3.4966774e-08,0.03475733,-0.07536152,-0.0060041803,0.039001413,0.02339079,0.04483896,-0.027193375,-0.022599434,0.048417255,-0.047742482,0.01798191,0.1681896,0.061553307,0.006000151,0.041868754,0.014072355,-0.022807462,0.0017116655,-0.010511231,-0.06898591,-0.08406215,-0.022265136,-0.046451572,0.017164296,0.025863707,-0.021033527,0.018604605,-0.034962602,-0.0060447706,-0.023784718,0.033749737,0.02840431,0.0010614559,-0.025588391,-0.046994545,-0.00066948304,0.008731339,0.0065895985,-0.010059012,0.041024413,0.03871675,-0.012578125,-0.10715456,0.006225412,0.0008481423,0.018162837,-0.039065845,0.023236427,-0.078875646,-0.009473462,-0.016936626,-0.021293236,0.049082607,0.010167825,-0.07904452,0.029392727,0.00013178079,-0.090960205,-0.04717763,0.02928022,0.03955461,0.04134356,0.19707,0.020096757 +1.1.1.393,"This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3beta-hydroxycholanate 3-dehydrogenase (NAD+).",384,1.0,-0.04428271,-0.06563292,-0.09559082,-0.0643198,0.012394646,0.059341315,-0.071081154,0.01154785,0.032361284,-0.002560082,0.057486255,-0.023649827,-0.06486465,-0.003330421,-0.032302894,0.015802246,-0.040743455,-0.0061444417,0.023849707,-0.058299083,0.018829623,0.014687814,0.0317642,-0.014079463,0.054410238,0.044191003,0.11128142,0.021924093,-0.05513014,-0.07964174,0.014027165,-0.039045256,0.08805136,-0.11774215,-0.014748651,0.0388228,-0.07986585,-0.03617451,0.014443973,0.044061463,0.0049528987,0.029602004,-0.0383571,-0.040008113,-0.03151934,-0.07173991,0.012539379,0.06876925,0.060797375,-0.035998296,-0.01143381,-0.005001007,-0.015075872,0.020944094,0.061778218,-0.029244557,-0.008952051,-0.025209686,-0.036215086,-0.07891574,0.006795592,-0.05002188,0.0922698,0.0041573485,0.058158044,-0.06274945,0.06334379,-0.10394991,-0.0054477802,-0.081312336,-0.17880726,-0.045449514,0.022815878,0.035583526,-0.028920151,0.041509442,-0.05408089,-0.044426322,0.103140905,-0.031118933,-0.018090881,-0.04710505,-0.033829432,0.1257474,0.0455314,-0.05510466,0.007228083,-0.030631984,-0.02486074,0.018854484,-0.017321588,-0.037406273,-0.040533077,0.047175333,-0.093671754,-0.0069922856,0.012987686,0.022904314,-0.004563094,-0.06078571,0.013885027,0.09709753,-0.015777923,-0.05420705,-0.04010431,0.0034112656,0.008613016,0.10819768,-0.0280306,-0.0038564696,0.01704388,-0.047195163,0.025704315,-0.078121476,-0.08483515,0.17125404,0.02172751,-0.06785095,-0.049129184,0.0052454467,0.024055207,0.007858088,0.04905932,0.012224147,-0.033591166,0.02170037,-0.09102976,9.627901e-34,0.068726204,0.027467275,-0.07413985,-0.05531929,0.042560216,0.022073064,-0.08051336,0.06695314,-0.016567508,-0.037724312,0.0028359732,-0.02251684,0.076698184,-0.009441711,-0.016909916,0.03493264,-0.007829178,-0.02240856,0.012653646,0.028422616,-0.021741262,0.057817437,0.012389407,-0.02838781,0.071056806,0.038901884,-0.04829051,0.019900456,-0.016596377,0.012881599,0.062321622,-0.07363202,-0.14312172,0.043423988,0.07467542,0.026196143,-0.032753766,-0.021448372,0.0027112425,0.081856646,-0.002383862,0.01788711,0.010834127,-0.03413888,0.030717704,-0.046361268,-0.046357207,0.08919547,0.107747,0.07295127,0.079470664,-0.0231805,0.1121192,-0.079824306,0.0033438879,0.014655425,-0.03249022,0.040861562,-0.015554137,0.03621308,0.008214008,0.09004218,-0.052100904,0.07906532,-0.049416833,-0.026613383,-0.051022597,-0.026447456,0.03143531,-0.011702828,-0.04878037,0.038989857,0.07937376,0.011182151,-0.025985153,-0.011179088,-0.0551655,0.011775476,0.046544317,-0.040419493,-0.044073336,0.012003086,0.029614365,-0.08613974,-0.037587993,0.0947736,-0.03955872,-0.023496566,-0.012022395,0.038322724,-0.0060521173,0.008920773,-0.041972883,-0.008237065,0.07161288,-3.731415e-33,0.033570707,-0.05605897,-0.01616188,-0.15294054,-0.026844576,0.09268535,0.023437284,-0.060213033,0.010080001,-0.054882605,0.06375857,0.024395037,0.03036051,-0.033638455,0.05437736,-0.018849023,-0.030164955,0.06321735,-0.053059805,-0.07776813,0.064919345,0.102521695,0.029002346,0.011613227,-0.008483,-0.022092147,0.0054539633,0.010434175,0.047740705,0.07056918,0.0060783722,0.022371395,-0.05826169,0.014189813,-0.0077237007,0.0146164615,-0.07212257,-0.021998359,0.0088676,0.011500362,0.012852305,0.0043977895,0.01196756,0.021698762,0.045272216,0.070602715,-0.03172876,0.0045384723,0.026655097,-0.0709682,0.016701376,0.011139214,-0.025120933,0.042889882,0.049830128,0.08716635,-0.031848233,0.0036606384,0.07520194,-0.05486504,-0.03964595,-0.02261812,0.09593987,-0.0052911965,0.035762154,0.026182527,0.008055518,-0.043052208,0.03794363,-0.006332222,0.060053233,0.042535085,-0.025992757,0.028216088,-0.012033847,-0.023951126,-0.07688715,0.019786812,-0.0054841503,-0.0619979,0.04104907,-0.009619522,0.017255716,-0.046819348,0.02649764,-0.063055836,-0.076237954,0.094839916,-0.020720426,0.017304868,-0.0019125269,0.048437573,-0.09656759,-0.019633899,-0.02540455,-3.88903e-08,0.05335607,-0.0661635,-0.02206078,0.0062638074,0.04508619,0.052879177,-0.022178328,-0.028192995,0.054253,-0.041571256,0.0034253183,0.18634768,0.04363988,0.016204929,0.014947135,-0.007563634,-0.035613604,-0.004957969,0.0020363268,-0.051396225,-0.09674004,0.0076474114,-0.092776,0.024068952,0.029075304,-0.033644468,0.014081154,-0.036673043,0.043177117,-0.038615957,0.0271525,0.04675729,0.033030394,-0.043011002,-0.032344542,0.0047111567,-0.013106816,0.041531783,-0.0112438835,0.076016866,0.018360468,-0.07062064,-0.0720499,-0.0036048342,0.033509642,0.028335452,0.0049232394,0.018326048,-0.10635655,-0.0215952,-0.029067116,-0.038522948,0.083018266,0.004813899,-0.07761217,0.024736378,0.003258229,-0.10103285,-0.03195061,0.023628408,0.020033156,-0.012241542,0.15692395,0.015128992 +1.1.1.394,"The enzyme from the bacterium Stigmatella aurantiaca catalyses the final step in the conversion of aurachin C to aurachin B. In vivo the enzyme catalyses the reduction of 4-[(2E,6E)-farnesyl]-4-hydroxy-2-methyl-3-oxo-3,4-dihydroquinoline-1-oxide to form 4-[(2E,6E)-farnesyl]-2-methyl-1-oxo-3,4-dihydroquinoline-3,4-diol (note that the reactions written above proceed from right to left), which then undergoes a spontaneous dehydration to form aurachin B.",384,1.0,-0.06893887,-0.02807635,0.033775814,0.024090713,0.034096085,0.06428462,0.038221817,0.05157051,0.039246418,-0.022471594,0.040594257,-0.13234207,-0.13048899,-0.062192347,-0.06794395,0.09820126,-0.016579255,-0.00013113201,-0.038100183,0.0028834837,-0.034121156,-0.06761024,-0.07419832,0.006758164,0.04220744,-0.045677073,0.076899245,-0.017064024,0.004774497,-0.060227476,0.025238505,-0.042519264,0.041430168,-0.047660675,0.032065988,0.049096264,-0.013987542,-0.12719923,0.084707804,0.005613807,0.050611835,0.061384317,-0.05200275,-0.00093155063,0.020494023,0.03298087,0.032377042,-0.0045885523,0.07272192,-0.028937474,-0.07159245,-0.08339392,-0.0795734,0.06207573,-0.09767704,0.022995025,-0.050932843,0.019081984,0.0105803255,0.029571358,-0.0013816669,0.0018601364,0.032988615,-0.01619832,0.05985763,-0.0007452162,-0.009563845,-0.03621113,0.104402974,-0.012457691,-0.0017889597,-0.009484452,-0.02853564,-0.002585173,0.008371885,0.029963352,-0.032021362,0.038629923,0.020517161,-0.07766824,0.016729679,0.039344214,0.06375051,0.07918197,-0.042281494,0.02919461,-0.030884327,-0.005291744,0.047838468,0.04190394,0.010647153,0.0027072795,-0.037496105,-0.019226555,-0.07736652,0.026203329,0.059773397,-0.0031859549,0.0874512,0.00051866006,-0.022228256,0.05292672,-0.051310576,-0.1488041,-0.08990866,-0.027377108,-0.05998998,0.011233422,0.061937083,-0.01568244,0.018910192,0.0033066808,0.003360454,0.02563464,-0.052540038,0.017000603,0.036520958,-0.038678788,-0.09343695,-0.009261011,0.056155786,0.011479775,0.052790947,-0.009429105,-0.06932868,0.009948964,-0.034260765,1.8385521e-33,0.037796378,0.003292944,0.018385444,0.016121274,-0.022471095,0.024665691,-0.07654476,0.010183797,-0.12094811,-0.0006533198,-0.07335033,-0.081934005,0.0011518084,-0.013547465,0.024520377,0.024670517,0.011613673,-0.0043510986,0.070283644,-0.028640542,0.045542266,0.044166364,-0.05126471,-0.058945276,-0.004555502,0.066852346,0.063151315,0.016608376,0.058227986,-0.018377151,0.009729943,-0.019989835,-0.054513775,-0.013636069,0.06226767,0.02176401,-0.02245291,-0.029184725,0.061565384,0.007349366,0.03777502,0.041061494,-0.092494406,0.008961253,0.04523785,0.018245328,-0.08111086,-0.030656837,0.09202922,-0.049609024,-0.040484592,-0.019919315,0.16170259,0.082771994,0.0015422856,-0.052400023,0.025380537,-0.061687607,-0.01871406,0.058633793,0.028449666,0.059558842,-0.048363462,0.03900104,-0.03444198,-0.030541116,-0.096694805,0.010079005,-0.04981284,-0.03613462,-0.037847634,-0.07946114,0.049751516,-0.026449325,-0.07428166,-0.077438824,-0.06289335,-0.022881096,-0.051274955,-0.052564368,-0.11675672,-0.009741316,0.033587314,-0.0011506429,0.00023924942,0.05521149,0.017073516,0.0019024829,-0.007912818,0.034164097,0.069229834,-0.029628588,-0.05982827,0.020531606,-0.04851272,-1.9068588e-33,0.027420066,-0.047921006,-0.09154767,-0.03194556,-0.0053338823,0.019172706,0.0458466,-0.008879954,0.013957711,0.01623009,0.03546516,0.03640754,-0.025403934,0.03901584,0.018847298,0.0252525,0.049348995,0.100153565,-0.06551453,-0.04160524,0.0059328848,0.013788733,-0.010985987,0.00587136,-0.011854491,0.060361203,0.11274146,0.09077219,0.07614441,0.053452533,0.02173827,0.00017773556,-0.0003753309,-0.013275297,0.008395229,0.020206757,-0.02890054,-0.008189635,0.03450363,0.048983794,0.0003941843,-0.054881934,-0.044426177,0.003944369,0.07930725,0.11439074,-0.081478804,0.058262937,-0.01683606,-9.054558e-05,0.102910414,-0.069471724,-0.032169614,0.042266585,-0.00271396,-0.015614525,0.07097484,-0.07719733,0.008659323,-0.10352466,-0.04247862,-0.06984352,0.09977639,-0.024253791,0.014368785,0.11011672,0.097312614,0.10516101,-0.004376474,-0.07394536,0.07939641,0.0709067,0.012992582,0.066263534,-0.058765065,0.042433854,0.0042434414,-0.021881163,0.06915593,-0.065582424,-0.034962032,-0.0075502302,0.084180035,-0.035200592,0.008716043,-0.04708697,0.015131786,0.08306882,-0.020740872,0.08605076,-0.04686084,-0.0237908,0.02576395,0.042728145,0.108019285,-4.328871e-08,0.04382957,-0.06583936,0.010152416,0.00077789614,-0.028749783,-0.0073908255,0.03444767,0.04413925,0.028049346,-0.005213652,-0.051949028,0.049709406,0.050330054,0.06415345,-0.0028329126,0.05503188,0.040461212,0.03668936,-0.05384532,-0.066485345,-0.0907362,0.018505,-0.022887992,-0.02949465,0.0074245892,-0.122594655,0.008018209,0.061965212,-0.017099142,-0.040190566,-0.017770752,0.017547049,0.04482481,0.0088975,-0.041543655,0.02822012,-0.064492375,-0.027969595,0.034117192,-0.0021276334,-0.053769093,0.009607981,-0.084841736,0.010337475,0.005266824,-0.064999215,0.019856663,-0.0014973099,0.029082969,0.10857442,0.033971146,0.009704827,0.027991936,-0.007943274,-0.118981525,0.022565482,-0.0919338,-0.02340197,-0.034957264,-0.048828196,0.029292915,0.011151587,0.08142906,-0.0047870465 +1.2.5.3,"This enzyme, found in carboxydotrophic bacteria, catalyses the oxidation of CO to CO2 under aerobic conditions. The enzyme contains a binuclear Mo-Cu cluster in which the copper is ligated to a molybdopterin center via a sulfur bridge. The enzyme also contains two [2Fe-2S] clusters and FAD, and belongs to the xanthine oxidoreductase family. The CO2 that is produced is assimilated by the Calvin-Benson-Basham cycle, while the electrons are transferred to a quinone via the FAD site, and continue through the electron transfer chain to a dioxygen terminal acceptor [5]. cf. EC 1.2.7.4, anaerobic carbon monoxide dehydrogenase.",384,1.0,-0.0576583,0.008129894,-0.13034509,-0.017473795,0.117900066,-0.0082891835,-0.10140246,0.02764778,0.008639414,-0.03298606,0.035027806,-0.10641306,-0.049194515,-0.03284196,-0.03636969,-0.0040583597,-0.052709024,-0.06685716,0.05251184,-0.029631978,0.014461403,0.022677258,-0.009947765,-0.023993757,0.009952955,0.082834594,0.021602897,-0.034492634,-0.035381597,-0.06303701,0.020044463,-0.017773628,0.03167459,0.018588621,0.005609015,0.08656083,0.053830083,-0.04031003,0.083688624,0.013786784,-0.021491207,0.056369074,0.05971238,-0.049525145,0.033817522,0.0033358426,0.02050791,0.041083995,-0.024786219,-0.05623292,0.006433464,-0.029879253,-0.02747985,0.03250251,0.036344,0.028620558,0.0047705537,-0.04812687,0.024727425,0.030520784,0.10276499,-0.008850807,0.020887988,0.042911626,0.0077000502,-0.09874399,0.033576716,-0.08194022,0.01824174,-0.10004326,-0.058153868,-0.00571577,-0.04009741,-0.05155664,-0.040809453,0.047729388,0.061670154,-0.08848737,0.114441216,0.0053562345,-0.02367635,0.03862972,0.10590469,0.020336347,0.03210586,-0.035641987,0.02026326,-0.013745614,-0.0032495814,0.04657782,-0.00090573356,0.02869759,0.001374672,-0.017845629,-0.08780102,0.027181758,0.11398608,0.11200394,0.024399748,-0.032009922,0.020775847,0.0826442,-0.013319784,-0.10305212,-0.072244376,-0.026989555,0.055624515,0.18059485,0.065950505,0.024532098,-0.036120795,0.03599474,0.040078208,-0.0056915986,0.014028058,0.123620324,0.03770791,-0.017158588,-0.06534558,0.04473041,0.042234078,-0.04705809,-0.014645055,0.054674298,-0.015645334,-0.029746426,-0.072109655,2.630443e-33,0.03700131,0.031443026,-0.030043218,-0.02351709,0.032630615,-0.0005687066,-0.16491212,0.03507875,-0.015983641,-0.01905206,-0.03643812,-0.015428879,0.042964146,0.009063554,-0.04323591,-0.105117105,-0.08556919,-0.025146013,0.023325298,-0.03019686,0.042463955,0.0721419,-0.023383802,0.071856685,0.04271271,0.05081953,0.020867856,0.008304922,0.0320268,-0.0025012414,0.033027224,-0.08621375,-0.055463616,0.035768405,0.02116653,-0.038006384,-0.029918026,-0.0039981175,-0.037412304,0.04849,0.020574309,0.020172643,0.012691872,-0.06082492,0.05092849,-0.09794752,-0.004773744,0.070194446,0.07136316,0.026290854,-0.004986681,-0.0025946621,0.04588048,0.0055166143,-0.03307658,0.026317265,-0.040289827,-0.014440581,0.0649141,0.043263946,0.05083865,0.052313585,-0.03354582,0.0357157,-0.016184347,-0.0069894595,-0.03621361,-0.042752065,0.053713165,0.13927521,-0.067062974,-0.03327208,0.055169955,0.019141227,0.061043467,-0.042208932,-0.02858191,-0.035753205,0.03942708,-0.03315217,-0.011063901,-0.028094385,0.05900857,-0.08517336,-0.015574462,-0.04500474,-0.09206755,-0.04605258,-0.031493567,0.028096007,-0.022442715,-0.016470011,-0.044404514,-0.033126626,0.027897151,-3.4908582e-33,0.07831097,-0.06352223,0.06376171,-0.12320149,-0.053720437,0.08107978,0.011508461,-0.08017395,0.049426943,-0.04224493,0.04816175,0.010959707,0.066392675,-0.008094412,0.07505031,0.002052507,-0.0082716,0.04388251,-0.039871875,-0.014527267,0.029060923,0.06403099,-0.0281008,-0.024860587,0.07883436,0.021527132,-0.06323813,0.020948162,0.14038032,0.029987486,-0.05949084,0.006549242,-0.016959378,0.0071347887,-0.052068815,0.044920463,-0.057992492,0.031583272,-0.038613424,0.037275355,-0.007890553,-0.037582796,-0.062381346,0.077557474,0.048016075,0.04475734,-0.09420027,-0.022255223,0.022250164,0.030299146,0.019843046,0.0031019212,-0.07794705,0.011425868,0.035484754,0.088313706,-0.007061847,0.0054959795,-0.009568837,-0.009606222,-0.020624718,-0.056955412,0.0060188137,-0.0358474,0.006395413,-0.019808797,-0.02706372,0.07283317,0.038984273,0.02475575,0.050304394,0.048631467,-0.032337762,-0.029201308,-0.065780595,-0.035653,-0.018898353,-0.031069612,-0.010332787,-0.03468928,0.0010807357,0.023720793,0.09220033,-0.031345278,0.004801363,-0.091382794,0.014189803,0.080521554,-0.022919724,0.022277799,-0.0449561,-0.0018458532,-0.00017527085,0.015898138,0.04844943,-4.2884334e-08,-0.054684434,-0.054311078,0.10274259,-0.008536659,0.02980686,0.114218414,0.038158372,-0.04509153,1.680784e-06,-0.0249194,0.014372392,0.08449845,0.024391657,-0.069007434,0.0059742895,0.019183882,-0.056737285,-0.010152091,-0.0077748424,0.01898518,-0.040485423,-0.07247972,-0.1008772,0.07644322,-0.058569968,-0.08266748,0.008578388,0.057470974,-0.057258092,-0.021541515,-0.07099728,0.047161117,0.032430433,-0.058604732,-0.06497133,-0.012074744,-0.0474458,-0.029856078,-0.062255364,0.0005173809,0.03973874,-0.007109348,-0.050559107,0.01971402,0.034567058,0.03516817,0.029255139,0.001485127,-0.002861726,-0.004382677,0.06285201,-0.030367926,-0.008106489,-0.018210355,-0.059023958,0.06793073,-0.0750426,-0.06469084,-0.015548569,-0.02093168,0.016032483,0.02142017,0.16023143,-0.091584176 +1.3.1.111,"The enzyme catalyses the successive reduction of the geranylgeraniol esterifying group to phytol, reducing three out of four double bonds, and transforming geranylgeranyl bacteriochlorophyllide a via dihydrogeranylgeranyl bacteriochlorophyllide a and tetrahydrogeranylgeranyl bacteriochlorophyllide a to bacteriochlorophyll a. The enzyme can also accept the pheophytin derivative geranylgeranyl bacteriopheophytin, converting it to bacteriopheophytin a.",384,1.0,-0.08162345,0.044747848,-0.04248629,0.00085983094,0.05737074,0.07842946,-0.048645295,0.02193136,0.045369342,-0.019676773,0.06502502,-0.0061535244,-0.084556095,0.07177393,0.0017067152,0.024532238,-0.15895008,0.11981037,-0.050377976,-0.04565397,0.04675157,0.023627412,-0.011996484,0.034934774,0.08040109,-0.06466421,-0.015150898,0.029994026,0.008713285,-0.026097426,0.0005612994,-0.044161197,0.00092053914,-0.009779924,0.043842383,0.049490396,-0.012175967,-0.08550781,0.07896955,0.030026827,0.013302341,0.027096268,-0.04514984,-0.03252163,-0.06877884,0.0054637818,-0.049087882,-0.013587488,-0.0021493013,-0.0323319,-0.12318554,0.019064054,-0.040147435,-0.044136155,0.02293658,-0.0035574718,-0.010902974,-0.04379412,0.025635038,0.06259857,0.055072036,-0.00010282846,-0.048665483,-0.024067247,-0.048129182,-0.05014217,0.043017004,-0.05336117,0.096539676,-0.038252685,-0.07960211,-0.0377922,-0.028178561,0.045416415,-0.015119417,0.00025120296,-0.04144775,0.024375964,-0.047736425,0.00077315845,0.06439277,-0.03197792,-0.0826631,0.04680001,0.026980214,0.0033328743,-0.07152178,0.056407142,0.0831815,0.0557484,0.024241319,-0.008043273,0.07033253,-0.054536685,-0.08060846,0.091386296,-0.032549575,-0.107779026,-0.027867846,0.036893535,0.0054209535,-0.0128737725,-0.0179806,-0.104406595,-0.023482928,-0.018113397,0.018095654,0.035552878,0.014702714,-0.021707257,0.04602826,0.0011160657,0.04638464,-0.023487609,-0.06805547,0.08133887,0.018520053,-0.023400579,-0.020355357,0.00066728884,0.029225897,-0.039176457,0.062717475,0.043157388,-0.055102237,0.005503218,-0.073515244,1.21843825e-32,0.07805129,0.02809024,-0.0042500296,0.04480164,0.02290038,0.0065518557,-0.081550226,0.04486777,-0.018448893,-0.06969925,-0.058745116,-0.07711337,-0.030408425,0.011019506,-0.06260056,-0.04210057,0.003992466,0.055075604,0.050725043,0.035868052,0.019478485,0.07648717,-0.05860394,0.062935136,0.037212625,0.018825686,-0.013016828,0.006583488,0.094708204,-0.008326457,0.039941557,-0.071225956,-0.092532694,-0.002755487,0.04108111,-0.05261008,-0.067496784,-0.04774557,0.029607294,0.08272938,-0.07643113,0.04522505,-0.048331514,0.050858542,0.10344612,0.065505646,-0.019208966,0.09929918,0.0321886,0.058205515,0.0036296162,0.011510224,0.0029728299,0.011005408,-0.091267325,0.03507907,0.016547335,0.001985661,0.013967242,0.06238275,0.049420685,0.04480484,-0.012608799,-0.057125825,0.050540432,-0.019681025,-0.0015092226,-0.049021102,0.0050252527,0.04778321,-0.07264481,-0.047112808,0.031387497,0.07583937,0.048965175,-0.049632575,-0.07836934,-0.036121,0.014970614,-0.055812318,-0.07164197,0.07280775,0.051645707,-0.0267754,-0.054275107,-0.017822558,-0.066296205,-0.02276702,0.036417864,-0.030389385,0.0053084255,-0.07050438,-0.0067795343,0.06114236,0.0016645272,-1.07685355e-32,0.09909571,-0.058254234,0.0146185495,-0.025857432,-0.056378677,-0.014449654,0.015865559,-0.045711532,-0.052632205,0.020037225,0.09804081,-0.01645858,0.017765066,-0.003670434,-0.025385438,-0.031638116,0.09933219,0.07359853,-0.050123155,0.081145555,-0.030168831,0.06231616,0.028057303,-0.005880045,0.037771586,0.033961922,0.019646892,0.05561639,0.04599104,0.025322037,-0.0016691424,-0.04322461,-0.053683497,-0.054267213,-0.03280727,0.04184506,-0.011282112,0.025914207,-0.041686036,0.001375515,0.042380072,-0.017396452,-0.0076709776,0.043974914,-0.0022582947,0.035597477,-0.053122465,-0.014662206,0.016254751,-0.015157037,-0.035743475,0.07108722,-0.018171674,-0.025374081,-0.03584874,0.027839575,0.07800269,-0.029611994,-0.03540522,-0.03457564,-0.009248614,-0.057833914,0.09429737,0.020282889,0.01635209,0.12402193,0.01430122,0.11141116,0.05571325,-0.10628617,0.025495443,0.030446554,0.09911069,0.038902584,-0.026460672,-0.00908688,-0.0075792717,-0.12559159,0.0013103305,-0.081812926,-0.0130549325,-0.04161851,-0.046346802,-0.10627295,-0.04261767,-0.038450755,0.061426543,0.03240039,-0.004116604,0.014198199,0.021536356,0.02823369,0.019036168,0.040737603,0.06951346,-4.3373653e-08,-0.035834014,-0.03493295,-0.009320599,-0.040963233,-0.009649284,0.017710572,-0.061483406,0.0052505783,1.5465295e-05,-0.035213478,-0.061469033,0.07868534,-0.03565826,0.0680497,0.035093177,-0.002783317,-0.037241857,0.00010350225,-0.008738159,-0.00813419,-0.060175706,0.019467717,-0.13685383,0.02149271,-0.0031043221,-0.059691157,-0.017057324,0.08643908,0.044513423,-0.028513495,0.022324374,-0.017716302,-0.03416953,0.07527151,-0.0012236285,-0.015674721,-0.117971204,-0.036493942,-0.04822318,0.0055317422,0.035420835,-0.006469962,-0.085035965,0.08491982,0.030544367,-0.037374686,0.0016730044,0.0024408894,0.0060363077,0.097203285,0.13553937,-0.030264976,0.034088288,-0.033811778,-0.08489853,-0.042475086,0.0072677922,-0.038958594,-0.11423702,0.009503594,0.014615351,-0.079832666,0.15419036,0.05147329 +1.3.7.12,"The enzyme participates in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The reaction requires reduced ferredoxin, which is generated from NADPH produced either through the pentose-phosphate pathway or by the action of photosystem I [1,2]. This reaction takes place while red chlorophyll catabolite is still bound to EC 1.14.15.17, pheophorbide a oxygenase [3]. Depending on the plant species used as the source of enzyme, one of two possible C-1 epimers of primary fluorescent chlorophyll catabolite (pFCC), pFCC-1 or pFCC-2, is normally formed, with all genera or species within a family producing the same isomer [3,4]. After modification and export, pFCCs are eventually imported into the vacuole, where the acidic environment causes their non-enzymic conversion into colourless breakdown products called non-fluorescent chlorophyll catabolites (NCCs) [2].",384,1.0,-0.01536314,-0.068586,-0.11672267,-0.021204308,0.18289667,0.053042624,-0.00239998,0.023775622,0.10368154,-0.009715541,0.034638885,-0.059924737,-0.07872208,-0.015847594,-0.031706434,0.052137095,-0.13316011,-0.01621836,-0.030066174,-0.035504736,0.03043797,-0.04064055,-0.018789813,-0.0060546426,-0.019383539,0.004987655,-0.0664466,-0.011106211,-0.023289043,-0.07441509,-0.03782707,0.02077809,0.0275727,0.009660264,0.055846237,0.10143874,-0.015963431,-0.11245455,-0.0038268059,-0.0386375,-0.0039322963,0.0004747438,-0.06573384,-0.008840352,-0.0504596,0.0042101364,0.059891023,-9.1598275e-05,-0.03972211,-0.06953298,0.02675176,-0.01208837,-0.04066845,-0.017352782,-0.016070792,0.022083692,0.025131794,-0.0053381063,0.0027859835,-0.036304068,-0.06093128,-0.032198746,-0.0015634627,0.008224456,-0.005463015,-0.020667186,0.007969994,-0.10739635,0.038287688,-0.091391325,-0.15041707,-0.01722966,-0.018107634,0.017437207,-0.010082625,0.08407428,0.014942557,0.027976982,-0.027508698,-0.007325515,0.04915245,0.048068047,-0.018139765,0.049871083,0.08966673,-0.004297913,0.0045646937,-0.035404,-0.016024215,0.020201806,0.0518722,0.07093916,0.008289939,0.069163464,-0.12901148,0.08261085,0.039810404,-0.03822101,0.038476028,-0.041908823,-0.02687525,0.053947333,-0.020463549,-0.08472318,-0.027617265,0.025913535,-0.06271367,0.063648425,0.027321545,0.023242483,-0.029984709,0.01911373,0.002035963,-0.012037837,0.037297882,0.085953705,-0.014911044,-0.045480873,-0.05122505,0.011985953,-0.033476204,-0.054093722,-0.048370533,0.069769196,-0.060153358,-0.00044354418,-0.05287111,4.1723173e-33,0.03944736,0.0096957255,0.0019661016,0.017967565,0.004059095,-0.005593996,-0.04922447,-0.021692177,-0.005823089,-0.10070676,-0.02272696,-0.07184844,-0.011049166,-0.084773906,-0.012352446,-0.04186893,-0.04634333,-0.014965559,0.019349677,0.052299634,-0.0010720151,0.049004942,-0.04418923,0.050126072,0.045769677,0.03544764,-0.04645031,0.018348705,0.030336231,-0.059671592,0.07351039,0.0019599171,-0.0703578,0.018608024,0.015321193,-0.067723066,-0.00645271,0.0064805113,-0.0061049047,0.07640195,-0.081564166,0.035208654,0.00031206314,-0.020089846,0.11402076,-0.09408492,-0.053877965,0.12802677,0.026478034,0.049512897,0.0017833016,-0.011890338,0.08292027,0.05141931,-0.021541497,0.038309313,0.010175278,-0.112125,-0.009323467,0.041382134,0.07810356,0.07448398,-0.013731994,0.04415398,0.012940288,0.06136297,-0.01974197,-0.012985191,0.01345155,0.053107113,-0.055362757,-0.024038134,0.018064402,0.008490616,0.08217303,-0.06489345,-0.011386575,0.024746258,0.012790318,0.0059346254,0.039576363,0.031041717,0.010968183,-0.06625476,-0.093117684,-0.029931461,-0.03663417,-0.043265767,-0.039597888,0.0256185,0.05547785,-0.051328268,0.034010306,-0.0029889029,-0.026531352,-4.347824e-33,0.10989481,-0.09444799,0.0104685975,-0.053790335,-0.04675634,0.04273306,-0.04134993,-0.027043507,0.0032391958,-0.007343336,0.030056031,0.05530639,0.003929319,0.042159606,-0.00019110668,-0.0033097505,-0.00974944,0.13079506,-0.030509714,0.020393372,-0.0009336653,0.07390312,0.012011391,0.024114288,0.027745388,0.022429097,-0.010619798,0.016681356,0.077100925,-0.0636401,-0.041618727,-0.009640855,-0.022214768,0.035820447,-0.008868704,-0.03943882,-0.06553724,-0.025982957,0.03684934,0.12989493,0.0036447097,0.02901937,-0.030797636,-0.03521546,-0.028488748,0.012938535,-0.10600303,0.030484356,-0.005328614,-0.027555408,-0.0072258036,0.08442671,-0.07257888,0.05720074,0.022670649,0.06305247,0.04764815,0.033776682,0.006363001,0.0010376564,-0.006709561,-0.02767804,0.012556005,0.039705995,0.05649507,0.024555763,0.030130047,0.12276784,0.017515989,0.06860586,0.09780079,0.06052871,0.024314394,0.004101733,-0.007829988,-0.029298898,-0.020122988,-0.014257194,-0.019897938,-0.02861183,-0.015551231,0.012726948,0.02782251,-0.07047148,-0.027864624,-0.10102699,-0.0044480567,0.008339987,0.043962374,0.013716734,0.04836473,-0.047226008,0.07337398,0.0689052,0.12196148,-4.449201e-08,-0.041116025,-0.0006036109,-0.00871119,-0.04527931,0.041637365,-0.026458813,0.057337314,-0.025410123,0.037987564,-0.051075876,-0.020970587,0.06797052,0.05226058,-0.061203167,0.061372288,0.068432346,0.029597953,-0.01753292,0.046513766,0.07922414,-0.118001595,-0.051814158,-0.13931604,0.0501714,0.023532173,-0.050660886,0.06743733,0.07835477,-0.023604833,0.038593512,0.061306514,0.024259765,0.086121514,-0.08921118,-0.021373073,0.027140442,-0.050292373,-0.07918543,-0.094117016,0.05794635,-0.05513008,-0.01689475,-0.041348316,-0.03914017,0.034168754,0.041373827,0.033873606,-0.023125526,0.014240114,0.054681886,0.041969065,-0.003898175,-0.021566728,-0.095971905,-0.11160445,0.011724649,0.031697836,0.035428163,0.0069173463,-0.0101496745,-0.011536469,-0.002568742,0.14723161,-0.013387901 +1.14.11.50,"The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.",384,1.0,-0.022701152,-0.014508341,-0.11058735,0.027510704,0.040791683,0.12355151,-0.034953155,-0.014379568,0.06033145,0.004332376,0.034030557,-0.025305716,-0.07784329,-0.023267612,-0.10443307,0.057034373,-0.1320885,-0.012709467,-0.011460762,-0.004532412,0.006790084,0.043004073,0.00601409,0.0182455,0.059720427,-0.0507534,-0.09506157,-0.0035048157,0.011612129,-0.060759943,-0.014920099,0.0867792,0.007453048,-0.029733092,0.07540362,0.09750324,-0.037021786,-0.017488439,0.0089518605,0.01756605,0.04482828,-0.04615613,-0.053926673,-0.003603543,-0.059502233,-0.02544292,-0.042721175,-0.05366,0.04490475,0.034683857,-0.03817384,-0.07762657,-0.034850042,-0.016122598,0.04527191,-0.019788545,0.027500179,0.027431235,0.0346575,-0.0054692375,0.11283657,-0.008331561,-0.0031534613,0.056191985,-0.019817388,-0.09970374,-0.01113225,-0.03110783,0.024510002,-0.018508848,0.032713577,-0.083647855,0.024029514,0.022038948,-0.026631959,0.027874304,-0.040082388,-0.024273382,-0.013681635,0.008087556,0.07580147,0.079252765,0.09458351,0.15067841,0.010211591,0.02111732,0.019881206,0.0012428906,-0.027444717,-0.027700696,0.06158678,-0.020454485,-0.027718745,-0.03644514,-0.03732193,0.05230184,0.05717878,-0.04183552,-0.013763856,-0.008864886,0.053599346,0.017317148,-0.10470276,-0.1441299,0.05362887,0.0139093865,-0.073842436,0.003786001,0.008948048,-0.032235585,-0.021100692,-0.046015438,-0.00067842833,0.012979549,-0.011414458,0.08223216,0.032902014,-0.035717912,-0.019969432,0.05846824,-0.020819413,-0.015643256,0.035487458,0.07698733,-0.057263482,-0.025394363,-0.069051094,3.1917217e-33,0.094817445,0.05285704,-0.016575236,-0.05444467,0.051776107,-0.086809665,-0.06310727,-0.059987728,-0.08959265,0.0070357835,-0.10924448,-0.023992082,0.007796692,0.023542851,0.009386118,-0.02637541,-0.064500146,-0.009147173,0.032253936,-0.07442494,0.018113572,-0.005505803,-0.12211034,0.008569417,-0.004949109,0.115071855,0.050038766,-0.0031314238,0.02918092,-0.021423,0.00555019,-0.024184285,-0.060219023,0.054473445,0.004384145,-0.015000249,-0.0006851378,-0.028861975,-0.040162407,0.06285362,0.048592877,0.011975316,0.008719737,-0.050684977,0.08960066,-0.0032253927,-0.05676852,0.040203284,0.049826767,0.05806626,0.028400369,-0.021519503,0.1035229,0.036636814,-0.045818493,0.027903233,-0.031695373,-0.013271459,0.016625343,0.022513352,-0.0057246694,-0.07892649,-0.033038236,0.04521778,0.026530746,0.064717665,-0.03934041,-0.11857741,-0.016527142,0.013828347,-0.09382477,-0.011213786,0.05700287,0.07198685,0.042046722,0.006023702,-0.046306215,0.060414683,-0.052282356,0.04098638,-0.0089735985,-0.0073828115,-0.0034089973,0.010544571,-0.023880554,-0.058931276,-0.009363311,0.0025668067,-0.024733096,0.015384001,-0.0009160494,-0.07727989,-0.077048786,0.017860176,-0.044943962,-4.3624256e-33,0.07318231,-0.08450716,0.095124304,-0.07889604,-0.028091868,0.10409485,-0.016936358,-0.011635044,0.04918568,0.070604235,0.048986092,0.00084152987,0.07291567,0.020554585,-0.025978165,-0.017330544,0.03867672,0.020073373,-0.019298112,-0.011398955,-0.07937668,-0.019216536,-0.06124229,0.038710557,0.014297738,0.023622334,0.018454105,-0.050127983,-0.011274137,0.057328418,-0.0157252,-0.023457019,-0.08735402,0.052826565,-0.019667828,0.042007875,-0.08441512,0.015077688,0.013925842,0.008222288,0.041246247,-0.012656633,0.025750075,0.0120534105,0.111268744,-0.011349544,-0.08400941,0.06295204,-0.012372879,-0.06517971,0.020884302,0.055846605,0.03294374,0.04859853,0.033354018,0.04853118,0.01260434,-0.04037051,0.005693639,-0.017666614,0.03478838,-0.021376505,0.026411725,0.05656478,-0.015454879,0.12074927,-0.024393778,0.020155005,-0.017904025,-0.027238987,0.07437785,0.015817348,0.05989573,0.08605872,-0.023884395,-0.03456344,-0.0019318018,-0.07227875,0.020984229,0.0033333413,0.045295604,0.029247273,0.0021548164,-0.050537203,-0.006033826,-0.030512484,0.06588871,0.114903145,0.022162244,-0.025324572,0.042207945,0.031379785,-0.0956631,-0.0020977622,0.08934325,-4.0401606e-08,0.081785984,-0.019959968,0.060192674,-0.07932241,-0.03452936,-0.017704627,0.05603714,0.0027370304,0.04581835,-0.05466111,-0.019687824,0.043013975,-0.028268604,-0.009094671,0.0059248446,0.0156209245,0.005529032,0.058829337,-0.0054030702,-0.0020420162,-0.056000605,0.0016224829,-0.032284766,-0.01288351,-0.016730804,-0.04166469,0.037539333,0.043444995,0.014029227,-0.055299893,0.020838609,0.059397325,-0.08415658,-0.005820924,-0.1354732,0.085920274,0.03287071,-0.09766382,4.186249e-05,-0.0013973686,-0.01206032,-0.046577662,-0.03927244,-0.043330695,-0.04698758,0.0016335042,0.051561303,-0.008857323,0.028304154,0.054502185,0.0019405955,-0.0075325854,0.002781012,-0.11813059,-0.10701758,0.028052108,0.03162087,-0.033946708,-0.036942765,-0.053062797,-0.0663415,-0.05254991,0.21882299,0.01883677 +1.14.13.210,"Contains FAD. The enzyme, isolated from the bacterium Burkholderia sp. DNT, can use both NADH and NADPH, but prefers NADPH. It has a narrow substrate range, but can also act on 4-nitrocatechol.",384,0.9999999,-0.022005059,-0.07495958,-0.07342373,-0.08139646,0.0694523,0.08757798,-0.056120798,0.028010787,0.043803476,-0.03005288,-0.016163612,-0.04235983,-0.086644776,0.04983433,-0.013506685,0.047249854,-0.024214936,-0.008356238,0.01884818,0.02874025,0.07217359,0.09289867,0.064312026,0.00778251,0.013128039,0.043838233,0.061167363,-0.006718109,0.053184014,-0.09818663,-0.059172586,0.025141481,-0.0056554475,-0.07350163,0.04941017,0.065324776,-0.020315854,0.06045707,0.03267901,0.026296476,0.042633884,-0.027098753,-0.007283438,0.00825547,-0.011100537,-0.004768491,-0.031983852,0.064077735,0.06758492,-0.011079962,-0.02885426,-0.059332628,0.044632576,0.045807354,0.049414426,-0.008751695,0.018157803,-0.046387006,-0.011075754,-0.02261256,0.03522661,-0.03321728,0.00950491,-0.02854418,0.047248825,-0.023664728,-0.027870608,-0.056578707,-0.0022385626,-0.10924316,-0.05075889,-0.017576402,0.04952421,0.045165315,0.0053673713,0.0500648,-0.015711088,-0.10186157,0.078450546,-0.03818931,0.047832757,0.029140413,0.05191436,0.10060042,0.05325671,0.02200169,0.005053789,0.03980012,-0.04850289,-0.014392871,0.03591255,-0.012393897,-0.019615622,-0.061186105,-0.11129715,0.027680624,0.0009813274,-0.006797339,0.028253026,-0.01999204,-0.0007798184,0.052913636,0.016502516,-0.057261713,-0.13394068,-0.0130071,-0.014930345,0.07823585,0.028928226,-0.020919576,-0.050323762,-0.0044168085,0.0071233925,-0.0076479972,-0.046724014,-0.02301385,0.029547598,-0.075513475,-0.07986527,-0.05744444,-0.040332515,0.0011297808,0.054784622,0.07076266,0.046940118,0.059961732,-0.10326168,6.543897e-34,0.14783709,0.008284435,-0.033027496,-0.030451296,0.014861896,0.015055531,-0.08669072,0.022645162,0.0071105147,-0.07405352,-0.012540648,-0.07303433,-0.015807984,-0.006082741,0.06730006,0.055882644,-0.036349777,-0.020392012,0.028446486,-0.019602066,0.080343366,0.13566434,-0.050747942,0.016873103,0.036321744,-0.054669324,-0.037849043,0.058816135,0.03705814,-0.00512408,0.059259836,-0.10957063,-0.103705816,0.005863643,0.028269796,0.020123068,-0.0799395,-0.051043652,-0.07329047,0.0067701694,-0.015852405,0.042279538,0.0088467365,-0.008052167,0.057736304,-0.10285728,-0.044175517,0.056704767,0.032083414,0.0609226,0.0409433,-0.00997538,0.06815085,-0.042372704,-0.057633303,-0.0038185054,-0.020165196,-0.025872096,0.038568445,0.061174974,0.01378319,0.070510134,-0.015599976,0.07544823,-0.0069638756,-0.010995203,-0.06347531,-0.038404725,0.009758179,0.091249056,0.016398057,0.018403154,0.018682057,0.021185035,-0.008737641,-0.11259318,0.0042511425,-0.015250654,0.0385199,-0.005708976,-0.0037176837,-0.08786501,-0.049695294,-0.019442588,-0.067985885,0.060393795,-0.009971188,-0.058672633,0.016102066,-0.030694129,0.040080324,-0.078331344,-0.041512888,-0.02172774,0.025609521,-1.4967045e-33,0.0625849,-0.04867426,0.09678805,-0.05945467,-0.032627735,0.111815654,0.041909438,-0.013674755,0.04201043,-0.07895663,0.051180862,0.05792613,0.034610275,-0.0011044263,0.036289126,0.033247486,-0.05443534,0.045286868,0.0034248016,-0.019696306,-0.03629902,0.092017286,0.027980119,0.017128896,0.11787683,-0.012950272,-0.054168355,0.077363536,0.02029244,0.049820915,0.04859083,0.043223236,-0.064581476,-0.03761233,-0.051969387,-0.022672176,-0.09277412,-0.016518375,-0.038203746,0.020771487,-0.012408432,0.01373705,-0.049510706,0.03278903,0.007940262,0.05579058,-0.071367174,0.005046866,0.112294674,-0.04423219,0.046988588,-0.0012268233,0.018889714,-0.028703842,0.050390888,0.01141175,-0.009752758,0.06651232,-0.036242966,-0.0045690597,-0.024315989,-0.054874375,-0.030282844,-0.029660827,0.06840943,-0.005516149,-0.027880626,0.055889152,0.053966697,-0.06714374,0.03376567,0.047466066,0.07134403,0.11821879,-0.03674799,0.022156307,-0.04618357,-0.023331808,0.028245097,0.04595492,0.01373347,0.035379708,-0.05785435,0.013555336,-0.05458615,0.023075562,0.04707295,-0.0121337315,-0.038752306,0.01086612,-0.023236958,0.07189645,0.0077442597,0.028963663,0.021314522,-3.3949522e-08,0.10661794,-0.05066299,0.05055073,-0.07487978,-0.016807351,-0.019696662,0.009068986,-0.0747125,0.0041606966,0.022082573,-0.04491988,0.10535172,-0.020656763,-0.002328266,0.055864032,-0.01624534,-0.008145309,0.0078664115,-0.05729554,-0.009344142,-0.08561104,-0.0034044392,-0.08066843,0.08077513,-0.03286519,-0.010644532,0.043763153,-0.049101833,0.07107811,-0.025436563,0.026262123,-0.0048345863,0.023397492,-0.03819836,-0.05448151,0.07200283,-0.06851642,0.0062988945,-0.08073782,0.11031758,0.046561,-0.10779624,-0.02279375,-0.018525507,-0.07284713,-0.051661387,-0.021652399,-0.053057507,-0.0439139,-0.013143428,0.016525181,-0.046668656,0.04662421,-0.012247281,-0.09373491,0.030869326,-0.031012816,-0.089807615,-0.03200667,-0.06917583,0.058016315,0.03670257,0.16653098,0.035755698 +1.14.13.211,"The enzyme has been found in a variety of environmental bacteria, notably Rhodococcus, Nocardia, and Streptomyces. It hydroxylates C-2 of rifampicin leading to its macro-ring cleaving.",384,0.99999994,-0.037424993,-0.049222376,-0.14021683,0.01516087,0.049863327,0.0388923,-0.11617361,0.06483026,0.041534703,-0.0484858,0.0030493943,-0.09908696,-0.0054192194,0.07659992,-0.073871955,0.00586211,-0.041510474,0.016796287,0.031283807,0.037739664,0.022524873,0.03439751,0.019059975,-0.0054564895,0.02067526,0.059056636,0.091991305,-0.04607074,-0.04514849,-0.10480032,0.044096388,0.015198434,0.0715,-0.03200962,0.104250796,0.07716272,-0.04382962,-0.03093571,0.11036004,0.036778543,-0.013325994,-0.010796344,0.058865584,0.0065158596,0.00022506012,-0.004143862,0.03534285,0.06108907,0.065657176,0.0047980463,-0.031112442,-0.03441043,-0.029715588,0.057246063,0.060989425,0.027197307,-0.079639055,-0.076110944,-0.012183788,0.0087181,0.112358205,0.004368081,0.043885827,0.0019160525,-0.07995036,-0.05154019,-0.030935887,-0.048198223,0.11648608,-0.055524122,-0.029836787,0.0064225732,0.022624774,0.007053064,0.008498639,0.029488385,0.016562091,0.010618067,0.036441926,-0.02788374,0.028377587,0.011998451,0.04089829,0.041048817,0.047068,-0.05855554,0.054845534,0.008434261,0.025061943,-0.0011574633,0.06112234,0.043226726,-0.0047939313,-0.07415635,-0.09892023,0.009805373,-0.03604545,0.019344417,0.0036031057,-0.055306025,-0.015680505,0.017722966,0.053486805,-0.08886988,-0.0036570013,0.012723,-0.018756526,0.06487091,0.081682704,-0.018496556,-0.012378027,0.089533724,-0.03271126,-0.038422767,0.061817527,0.08022111,0.103607476,-0.09562055,-0.09611818,0.05259668,-0.05305408,-0.10347997,-0.012164452,-0.04334809,-0.07428406,0.09661751,-0.11414505,7.974726e-34,-0.012544133,-0.032610897,0.0073512997,-0.0572442,0.028448367,-0.008050622,-0.056939807,0.027407156,-0.007174521,-0.13480036,0.017416352,-0.011920017,0.0013297455,0.046652094,-0.019607242,-0.047185645,0.037918393,-0.040648248,0.032236196,-0.036334842,0.015905987,0.043392964,-0.032927334,-0.00017066498,0.024037892,0.07180207,0.053951688,0.0036285508,0.11032343,-0.0063472935,0.04945317,-0.073232315,-0.04738269,0.020190515,0.07447507,0.012534887,-0.030425487,0.024691742,-0.018610029,0.041486524,-0.017910674,-0.011496808,-0.017897941,-0.10645257,0.07481056,-0.13645276,-0.015262848,0.13021772,0.023925744,0.04366778,0.08763255,-0.026546078,0.04469015,0.030685835,-0.011170556,-0.008117493,-0.0081115095,-0.015684072,0.030596158,-0.04525186,0.011899153,0.05712772,-0.07699653,0.030399932,0.0040117577,-0.017466558,-0.06217107,-0.029580798,-0.032535274,0.09352383,-0.0252805,-0.021166885,-0.042960923,0.044797376,-0.024520244,-0.013968726,-0.1089773,0.010358509,0.09839317,-0.0130096255,-0.0331957,0.067382805,0.0435217,-0.009904334,-0.047101486,-0.021860538,-0.039991032,-0.04246958,-0.05222571,0.021827798,0.04526199,-0.036034502,-0.1142523,0.02081241,-0.008487562,-2.2883231e-33,0.11221118,-0.14269197,0.025730776,-0.02246907,-0.016382603,0.05963059,-0.019911634,-0.014342098,0.007881131,-0.066864274,0.04604634,-0.003280092,0.010846847,0.007885531,0.13629425,-0.015952267,0.0480353,0.05149697,-0.020145899,0.011266798,0.03146673,-0.016148722,0.007918747,-0.010662626,-0.044054504,0.028815959,-0.015572121,0.014389272,-0.0048085945,0.07536941,-0.068375304,0.009411431,-0.04282074,-0.06650633,-0.03691097,0.02553282,-0.03814643,0.01650886,0.022471154,-0.051075738,0.03285546,-0.018515605,-0.056281615,0.07040738,0.032191068,0.037844922,-0.028311932,0.0016696452,-0.028863953,-0.029954143,-0.0029518793,-0.038342595,0.022596598,0.022611778,-0.055518422,0.051405057,-0.057997823,-0.00729536,0.015209057,-0.035180785,-0.05401174,-0.045824885,-0.02640879,-0.0036927762,0.063190855,0.05617614,-0.011699002,0.05695266,0.024969948,-0.09020442,0.07652116,0.037501242,-0.04817174,0.04468226,-0.097957276,0.03418382,-0.031090137,-0.014993675,0.034399677,0.056726646,0.049887136,-0.0056001362,0.023844946,-0.09522755,-0.013667562,-0.05214947,0.060531043,0.0072886692,0.012937449,0.050287217,-0.0030116863,0.017606642,-0.0943001,0.047928423,0.09239297,-3.3717505e-08,-0.0049163424,-0.08157273,0.09264175,-0.03693211,0.0341141,-0.0030914398,-0.009266104,0.0059986566,-0.014433964,0.0313677,-0.004629252,0.059035305,-0.037380695,-0.013218472,0.029254027,0.01411981,0.0076140407,-0.048771508,-0.02411877,0.023535658,-0.06705905,-0.0033279145,-0.021246994,0.060108297,0.016833562,-0.08143633,0.032870937,-0.03360497,-0.042300157,0.02556755,0.027152147,0.016253822,0.07715779,-0.020355538,-0.09560854,-0.05392488,0.036504284,-0.058827557,-0.04990699,-0.008413236,0.09114429,0.023635698,-0.060145628,-0.04199908,-0.018640703,-0.0037425987,-0.022478258,0.02667306,-0.010546042,-0.05112424,0.0082366895,-0.024032397,-0.05427162,-0.016688125,-0.11468758,0.009122118,0.009739814,-0.036584172,-0.032080777,-0.06273758,-0.02391173,0.040301863,0.16730465,0.05149727 +1.14.13.212,"The enzyme, characterized from the bacterium Pseudomonas sp. CBB1, is part of the bacterial C-8 oxidation-based caffeine degradation pathway. The product decomposes spontaneously to a racemic mixture of 3,6,8-trimethylallantoin. The enzyme shows no acitivity with urate. cf. EC 1.14.13.113, FAD-dependent urate hydroxylase.",384,0.99999994,-0.07294647,-0.012761393,-0.036804374,0.046222787,0.016234051,0.035765637,-0.052321553,0.092187054,0.006832691,-0.06661655,-0.09656992,-0.091718376,0.015681475,0.06365186,-0.07264643,0.01445582,-0.03920808,-0.034022827,0.0070305374,0.006440533,0.05293176,0.05296344,-0.023485849,0.028535416,0.058777526,-0.0088876495,0.11851216,-0.06716271,-0.042787097,-0.027489832,-0.019087426,-0.015064218,0.041688003,-0.062337622,0.070791736,0.104777664,0.00067853625,-0.06690977,0.11142458,0.023377782,-0.002020891,0.03616561,0.046080224,-0.017608663,0.015277035,0.0077554067,0.02088538,0.006242153,0.03901062,-0.020705812,-0.08056337,-0.020373983,0.023062924,0.09846212,0.08087911,-0.003104172,-0.029831646,-0.05692152,0.025215803,0.047683362,0.008079221,-0.058072977,0.0324597,0.027248986,0.01330088,-0.021845445,-0.0042152638,-0.050050728,0.06873138,-0.069451615,-0.08875756,-0.06781378,0.0105082365,-0.014671929,-0.009381683,0.014221906,-0.005630567,0.00093087275,-0.015464445,-0.07534936,0.034348976,-0.079939514,0.07733866,0.08939138,0.0282349,-0.09457843,0.06317108,-0.026376424,0.018178068,0.045801647,0.031039359,0.081052236,0.033811726,-0.04666147,-0.050850544,-0.021966835,0.044885717,0.0045068725,0.019190924,-0.0012664887,-0.023682402,0.055012804,-0.016912075,-0.0494524,0.014508106,-0.036885865,-0.04343422,0.11731094,0.11170843,-0.003277872,0.026279325,0.0107917255,-0.016017744,0.03245078,-0.045342017,0.029434888,0.047479928,-0.044846077,-0.034386512,-0.016498974,-0.021860816,-0.036643263,0.040197045,0.013220817,-0.06476216,-0.06424748,-0.041823406,1.6366603e-33,0.027434496,-0.025637781,-0.028610004,-0.092628695,0.0215614,-0.041354585,-0.041457247,0.012458464,0.04013487,-0.11926663,-0.033290245,-0.02003709,-0.026281249,-0.026069775,-0.02544926,-0.023761896,-0.08930212,0.012497042,0.052201666,-0.07156534,0.0671933,0.065781415,-0.01442199,-0.008136394,-0.0008315826,0.026719796,0.075611494,0.05048509,-0.05225924,-0.009095776,-0.011868068,-0.001943665,-0.13144769,-0.033616483,0.03140058,-0.015487172,0.034435652,0.02204014,-0.035225414,0.12010776,-0.028044527,0.028921867,0.028539823,-0.06844914,0.066722564,-0.107206896,-0.09849089,0.09554774,-0.03285582,0.15652254,-0.038184628,-0.05520379,0.09966511,0.04004172,-0.08572336,-0.0741086,-0.022987379,-0.04377994,0.064377785,-0.022270879,0.06974817,0.08160918,-0.04163281,-0.019790955,-0.06955399,-0.00792116,-0.028629724,-0.026227253,0.008682001,0.011009848,-0.02117362,0.02053614,0.026021473,-0.0019927372,0.02961018,-0.089601554,-0.09788598,0.04846415,0.008041538,-0.0057383054,0.017974319,-0.05587726,0.058068614,0.00984667,-0.042782515,-0.0037364804,0.030466994,-0.03320297,-0.096231855,-0.027435286,0.040191885,-0.008999365,-0.04584736,0.091175765,-0.014123581,-1.400842e-33,0.13580161,-0.09756602,0.1283994,-0.029003318,-0.02307159,0.0027691138,0.017273847,0.019003868,-0.027237838,-0.027873773,0.082633585,0.056736056,0.06081924,-0.03216564,-0.0062515885,0.02866839,0.018248692,0.014216017,-0.08923627,-0.024062287,0.038772017,-0.002925436,-0.09763563,0.030519392,0.024184568,0.04358486,0.0179643,-0.0021353834,0.093252726,0.07334534,-0.003984484,0.065972574,-0.07981439,-0.004612975,-0.00589928,0.064192556,-0.062221184,0.030950334,0.013125346,-0.0012316783,0.07238082,0.01555885,-0.08766653,0.071738206,0.053165607,0.035700418,-0.07347863,-0.010426236,-0.0039979145,-0.02392698,0.060826674,-0.015065964,0.02924975,0.007129168,-0.039431863,0.025019407,0.008848972,0.033327054,-0.036785197,-0.0023087035,0.039875913,-0.0033684976,0.033765063,-0.008880853,0.017629983,0.027185468,-0.047143083,0.09452622,0.052481167,-0.022391185,0.14712194,0.010750864,0.04093121,0.036082715,-0.047283746,0.018236943,0.0020776514,-0.018078351,-0.0050948556,0.023363914,0.044713642,0.03634885,0.024796698,-0.044981368,-0.019017922,-0.044758536,0.053009484,0.028908627,-0.005613492,0.047183387,-0.025388166,-0.004610918,-0.04761433,0.050780617,0.08226264,-3.737983e-08,0.008773279,-0.06682751,0.040580384,0.06643273,0.008032158,0.029604273,-0.018400071,-0.018799694,0.06417116,-0.06747731,-0.02720654,0.029414859,-0.031257287,0.03770566,-0.019434594,0.006632652,-0.07487465,0.01901866,-0.0007797258,0.050314475,-0.09376314,-0.086940095,-0.033544835,0.01815009,0.04968065,-0.06393605,0.00464008,0.045202266,-0.03194809,-0.05471339,-0.032649696,0.04416072,-0.03834928,0.014162195,-0.0712707,0.04081881,0.01933593,-0.036000133,-0.07069366,0.0059767566,-0.03544632,-0.07740178,-0.092912115,-0.014556566,0.028843451,-0.03815606,-0.0061754063,0.024931956,-0.039884634,-0.00833841,0.12481939,-0.0107500255,-0.0037050396,-0.04365139,-0.057304528,0.03887397,-0.016712386,-0.028782366,-0.048270952,-0.06198026,0.089976944,0.011466735,0.14482167,-0.010623341 +1.14.13.213,"This cytochrome P-450 enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.",384,1.0,-0.03651846,0.030319646,-0.053489555,-0.007130437,0.035960022,0.12200002,-0.044574257,0.01898551,0.024772545,0.013746064,0.016377429,-0.0071469448,-0.04250287,0.015185042,-0.06715666,0.061522994,-0.06664837,-0.01717448,-0.024187097,-0.014296077,-0.010379445,0.030124335,0.06560645,0.03395519,0.0043269754,-0.022660488,-0.055300217,0.072334826,-0.00016776726,-0.037648685,-0.02991245,0.08475273,0.014740923,-0.021631565,0.04134748,0.088079385,-0.07785276,-0.02987371,-0.018030435,0.021419944,0.06654941,-0.06400911,-0.09668692,0.045650654,-0.013701146,-0.070051074,-0.08591082,-0.058046073,0.030153722,0.009530542,-0.036364593,-0.048605792,-0.032270286,-0.028799394,0.024120275,-0.04501573,0.0750843,0.0131633375,0.022968898,-0.044006135,0.05502467,0.026772348,-0.004329245,0.057709366,-0.012898505,-0.035856206,-0.019265587,-0.06021697,-0.010976426,-0.019841017,-0.02112978,-0.10950036,0.0426418,0.027159695,-0.08469015,0.016778728,-0.007864743,0.01195607,-0.05432179,0.012756765,0.08728405,0.06575893,0.03493744,0.12092739,0.014012786,0.018062515,-0.002411801,0.039482582,-0.019759336,-0.063079596,-0.0037317984,0.0009699706,-0.04097639,0.0043574134,-0.089562625,0.053688288,0.025701338,-0.036314357,-0.020989012,-0.041641813,0.077679895,0.034102194,-0.09222073,-0.14330566,0.003209658,-0.008621238,-0.050177336,0.0130503,0.019391626,-0.04862076,-0.042995725,-0.05135347,-0.07223901,-0.004187519,0.008453603,0.07057664,0.008437548,-0.013213527,-0.0011576848,0.038551994,-0.015853038,-0.06605561,0.023056816,0.05226603,-0.06255588,-0.008727357,-0.09197227,3.3931144e-33,0.108559705,0.03934465,-0.026788093,-0.012573882,0.07083557,-0.047862176,-0.033716753,-0.061003108,-0.110278785,-0.031002639,-0.106566794,-0.028615572,-0.010369858,0.006391316,-0.035271663,0.015537768,-0.09618658,0.017804345,0.051498517,-0.043304246,0.022255078,-0.015526795,-0.083590105,-0.009447385,0.016262818,0.14640146,0.005972698,-0.013204458,0.033689387,-0.019360354,0.0026049423,-0.035093926,-0.06540069,-0.018463999,-0.008543474,-0.01954723,-0.016385589,-0.028413959,-0.04682997,0.047608115,-0.02303817,-0.04909149,0.041472737,-0.04970517,0.082157426,0.0038738735,-0.10681887,0.026417617,0.026399212,0.04815418,0.044254877,-0.025956089,0.07183417,0.06703378,-0.081900276,0.022081552,-0.023683624,0.011699473,-0.029902296,0.039573163,0.064098336,-0.028914392,-0.027922789,0.048255064,0.056267276,0.06830651,-0.013599569,-0.062828004,0.0014573687,0.08350404,-0.08283769,-0.024338307,0.09109845,0.06083687,0.06926159,-0.0029618836,0.00024463196,0.0808792,-0.021052688,0.071028315,-0.007989862,-0.034568183,0.0051818327,-0.0028879205,-0.025727164,-0.049890973,0.019386206,0.016035458,-0.028850576,0.031843763,0.031021,-0.078933015,-0.010912883,0.028883524,-0.06829694,-4.7974264e-33,0.056225147,-0.042789202,0.059020594,-0.084025435,-0.053719632,0.068158045,-0.022419425,-0.01854743,0.02386736,0.074020825,0.08313772,-0.025355771,0.07445791,0.015912335,-0.039400555,-0.012623929,0.018519584,0.046910364,-0.040110327,0.037265807,-0.037549786,-0.008289563,-0.032702938,0.030670403,0.02296659,0.03500761,0.064167626,-0.04193177,-0.01444461,-0.0021769449,-0.04762425,0.055348735,-0.09226692,0.016545711,-0.008469588,0.0010339583,-0.07018986,-0.004328954,0.016093021,0.03838119,0.0014264361,0.040606316,0.010559307,0.01921013,0.049607508,0.045985334,-0.08418047,0.015230256,0.027134953,-0.045809343,0.013007117,0.08364384,0.007282933,0.070313066,0.022701627,0.027473284,-0.0218836,-0.020200154,0.009381238,-0.02603061,0.012555854,-0.003209338,0.02175848,0.10637211,0.0013129141,0.14000884,-0.00833084,0.015604557,-0.00689014,-0.0063170865,0.030176826,0.00695898,0.066610456,0.11011077,-0.05238535,0.0027259444,0.0072523826,-0.05721832,0.042266227,0.01873398,0.06555369,0.006803589,-0.032581933,-0.049789533,-0.03625221,-0.07970752,-0.0033737388,0.12451265,0.05742549,-0.075703435,0.05063146,0.06017187,-0.08984259,-0.0011178781,0.079347454,-3.4356326e-08,0.054040063,-0.021699036,0.046762414,-0.06050111,0.020287441,-0.020957297,0.04242061,-0.011098295,0.07537592,-0.04617165,0.0020460347,0.023394162,-0.04504111,-0.011969417,0.012102026,0.0088162,0.037865628,0.049402636,0.05367098,0.016480343,-0.0846149,-0.010978099,-0.02552069,0.0022288559,0.027611371,-0.06299539,0.021354027,0.030878935,0.0540952,-0.050343253,-0.013661776,0.05048942,-0.09145745,-0.0056638694,-0.07839082,0.096029595,0.017488822,-0.08470057,-0.026946772,0.008108115,-0.02048999,-0.08097265,-0.02676498,-0.04590493,-0.03347611,-0.01478476,0.06645579,-0.017773418,0.018184656,0.026864126,-0.016569747,0.010763974,0.025962275,-0.14477484,-0.13085811,0.04984279,0.04849663,-0.04588518,-0.050745178,-0.08268385,-0.0383382,-0.07138352,0.23166399,-0.0020341869 +1.14.13.214,"This cytochrome P-450 enzyme, characterized from the plant Sinopodophyllum hexandrum, produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency.",384,1.0,-0.06002294,0.032538194,-0.04940095,-0.030139437,0.058267485,0.06427484,0.00065202935,0.064288124,0.031216921,0.06697005,0.032527667,-0.0243814,-0.023937695,-0.009725868,-0.042466074,0.08958759,-0.022614898,-0.0015975928,0.024347017,-0.041969523,0.010173579,0.013220461,0.07107805,0.036343656,0.027706103,0.024364693,-0.03976105,0.08277769,-0.021223463,-0.038286008,-0.0027767364,0.03694243,0.025831684,-0.007274532,-0.01893264,0.06381876,-0.0917075,-0.008928119,-0.022145726,-0.02515252,0.057597443,-0.026529014,-0.054770295,0.032064255,-0.00611566,-0.09659495,-0.10149064,-0.0039194818,0.027897084,-0.015261179,0.04340984,-0.060215127,-0.045280915,-0.017956251,0.016026556,-0.03159568,-0.0049681123,-0.0030371158,0.017185288,-0.030531855,0.06361777,0.01192219,-0.007125518,0.07779648,-0.02824288,-0.009799897,0.005908112,-0.050248645,-0.010303498,0.03882502,-0.032823626,-0.06562224,0.026368815,0.04044604,-0.07730938,0.016133787,0.020238718,0.013894337,-0.0063521466,0.015739558,0.07978176,0.12468342,0.033804193,0.06822767,0.0643285,0.0748756,0.021069748,0.028752888,-0.01547712,-0.098685026,0.025703324,0.008460595,-0.07741789,0.022434285,-0.069016345,0.062433586,0.00011606477,-0.04848789,-0.045145415,-0.03908888,0.08864654,0.071634404,-0.08754277,-0.1773567,-0.035236295,0.0007330431,0.017751684,0.009657291,0.006469144,-0.012054506,-0.05551153,-0.08866941,-0.07694722,-0.0042646118,-0.019765325,0.12355568,-0.012163715,-0.03633677,0.007817097,-0.015851248,-0.016716711,-0.07735524,-0.028277652,0.06102672,-0.060350068,0.013429693,-0.055197887,3.1751513e-33,0.10259084,0.01594579,-0.05130731,0.02306607,0.090825036,0.025527822,0.007764744,-0.024935968,-0.11950184,-0.036876477,-0.13938238,-0.044514,0.0115336375,0.055519234,-0.011507689,0.004496753,-0.051510595,0.03551274,0.076689854,-0.036995802,0.0360275,-0.04183191,-0.07502805,-0.0307532,0.0078098504,0.1443638,-0.053307064,0.0063317586,0.067480616,-0.02498927,-0.031156935,-0.02798359,-0.0850391,0.00085389224,-0.04382832,-0.007008747,-0.056788165,0.0017086555,0.008794186,0.08443365,-0.031732433,-0.006084995,0.062015735,-0.043912057,0.08805977,-0.022358472,-0.101569444,0.019552277,0.020012265,0.045556467,0.057746544,-0.008182074,0.068164825,0.050593946,-0.08652017,-0.0031554806,-0.012375672,0.054086003,-0.015588093,0.029681876,0.07364418,0.015062979,-0.031777903,0.0400818,0.015813598,0.054263543,-0.010676201,-0.07123184,-0.023945108,0.0565564,-0.045371857,-0.033406924,0.036671028,-0.0017746857,0.114757165,-0.007570453,-0.00903738,0.09238691,0.011192734,0.07471849,0.012504231,-0.055969723,-0.019372271,-0.028172927,-0.0009692392,-0.05102959,-0.022640064,0.020552397,0.021643702,0.057804313,0.05496389,-0.0819385,-0.033018846,0.018326595,-0.04280643,-3.3383055e-33,0.06986286,-0.033016868,0.020327665,-0.06901309,-0.07936535,0.06555945,-0.007360287,-0.06474991,0.032400884,0.055304397,0.0863103,-0.036775257,0.09196808,-0.0071823155,-0.001956728,-0.016614124,-0.008922276,0.05945748,-0.0040045227,0.026383035,-0.018505996,0.009558567,-0.007164517,0.0336189,0.05378566,0.02127674,0.06709792,-0.055937212,0.019392435,-0.037254214,-0.08425928,0.013767841,-0.10335018,0.021019468,-0.048059203,0.025796607,-0.038778957,-0.027342897,0.009633185,0.033511262,0.008074167,0.051619235,0.0144456355,0.045684602,0.0029875261,0.005338325,-0.072642624,0.028259357,0.010092575,-0.028245134,0.0015708972,0.057245057,-0.0063047237,0.039397065,0.0451093,0.022834139,-0.012484152,-0.037580848,-0.021447293,-0.02703286,-0.028927164,-0.01361626,-0.01524353,0.06746637,0.03172107,0.17574543,-0.0526968,0.056733612,-0.024400884,0.008319336,0.037511934,0.0048417547,-0.018197928,0.04503264,-0.057850197,-0.01199151,0.05342695,-0.06483446,0.031808168,-0.0028944078,0.061481807,-0.03509021,-0.040531326,-0.046153534,-0.061787385,-0.06864596,-0.022082286,0.087920316,-0.00833556,-0.015247734,0.060804486,0.026554527,-0.06961403,0.04462219,0.0959894,-3.4392894e-08,0.003243091,-0.05326647,0.050647866,-0.06081072,0.012221678,-0.056066237,0.08416466,0.00024482008,0.0580741,-0.07495255,-0.007110459,0.047461238,0.026720263,-0.010292868,0.058216624,0.020293152,0.05570424,0.03695085,0.031543843,0.009799615,-0.051118657,-0.042312328,-0.044284705,0.011754419,0.023771346,-0.0645861,0.05940162,0.029813265,0.069344476,-0.014282856,-0.052439347,0.022848537,-0.095775455,0.004527508,-0.023731872,0.0482504,-0.004182397,-0.06512017,-0.039436877,-0.007885492,-0.029453436,-0.05491156,-0.012844072,-0.050603542,-0.010671138,-0.023904093,0.060835548,-0.044366255,0.046817634,-0.012145636,-0.03589884,-0.013909289,0.064255,-0.14337464,-0.12231203,0.001068248,0.022212885,-0.019648971,-0.0005120244,-0.044193074,-0.04469626,-0.045299172,0.22013086,0.050500937 +1.14.13.215,"The enzyme, characterized from the bacterium Streptomyces nodosus subsp. asukaensis, is involved in the biosynthesis of the antibiotic asukamycin. Requires a flavin cofactor, with no preference among FMN, FAD or riboflavin. When flavin concentration is low, activity is enhanced by the presence of the NADH-dependent flavin-reductase AsuE2.",384,1.0,-0.08543603,-0.014550385,-0.20107278,0.023183323,0.0022843562,0.0653504,-0.06210473,0.10241805,0.024862705,-0.08684264,0.008477256,-0.025483709,-0.012351938,0.074080504,-0.08480663,-0.017058533,-0.02037699,-0.006382217,-0.006942424,-0.041637685,0.016436886,0.07536236,0.08221408,-0.019032734,0.037608072,-0.08071806,-0.014695904,-0.018826257,0.004797889,-0.09987825,0.07595745,0.04683,0.13384609,-0.015862368,0.08565252,0.09503104,0.030633787,-0.06150491,0.09857278,0.043903485,-0.033856004,0.014307778,0.07352145,0.005370574,-0.0044955807,0.030266259,0.00831131,0.10163284,0.066496484,0.06644131,-0.082153946,0.0010471737,-0.078735925,0.014846938,0.054326847,0.060633477,-0.0017770206,-0.06546127,-0.077616006,-0.051308937,0.086967774,-0.012882791,0.02312991,0.042192593,-0.052872095,-0.026436608,-0.037508912,-0.058095112,0.04463899,0.023118876,-0.03664015,-0.039963104,-0.008589384,0.0058476133,-0.029267171,-0.015281569,-0.008229506,-0.013427733,-0.03616337,-0.017653825,0.07228916,-0.008272539,0.0465987,0.07059915,0.029422326,-0.04418147,0.016182542,0.02621005,0.044351466,0.12760392,0.037636843,0.027922502,0.016221495,-0.08774524,-0.07829884,0.028724758,0.03788458,0.011076407,0.001252451,-0.0007091274,-0.04194256,-0.013229058,0.044101052,0.023101257,-0.018541988,-0.021863744,-0.024812791,-0.0015849855,0.031888884,-0.056665145,0.025430035,-0.015502448,-0.031375386,-0.08490825,-0.05634222,0.06635101,0.06651932,-0.10789087,-0.113901235,0.017185133,-0.0038521932,0.005503683,0.009058139,0.08349603,0.034727927,0.0245664,-0.1656781,3.6064145e-33,0.030906264,0.04170942,-0.029500095,-0.06441983,-0.013603241,-0.03477219,-0.06527178,-0.042584334,-0.007839217,-0.07068441,-0.05638245,-0.050185855,0.032424085,0.008136198,0.028341757,-0.04054827,-0.03606996,-0.01427389,-0.004454798,-0.02371682,0.08152347,0.0071955924,-0.037616987,0.03697724,0.041887604,0.04006159,0.002743885,0.08155664,0.033956554,-0.033985347,0.06489351,-0.08595579,-0.04533563,0.027976176,0.07479416,-0.02299446,-0.12081056,-0.059803452,0.017258817,0.0550154,-0.021685407,0.02990031,-0.040050942,0.011582034,0.059491854,-0.08231599,-0.052005146,0.051269736,0.076274514,0.08168116,0.028137716,-0.012408666,0.0814271,-0.00623586,-0.0028143404,0.01800637,-0.027900198,0.045155853,0.024957387,0.051277705,0.016190011,-0.068147734,-0.03624512,0.030669393,0.0068855244,0.024527503,0.038614918,-0.06171425,0.010690305,0.012106024,-0.039232872,-0.049140513,0.03048712,0.054768268,0.0185696,-0.009316936,-0.03371056,-0.027608028,0.018799795,-0.01977106,-0.05493556,0.0043502017,-0.029851284,-0.024981285,-0.06300487,0.017014896,0.012094419,-0.07416103,0.013194777,0.010391061,-0.011865849,-0.09768347,-0.07288375,0.01094347,0.084946655,-4.8460122e-33,0.03848513,-0.07074007,0.048210066,-0.039529286,-0.047570378,0.098514654,0.026102545,-0.05197577,0.021976748,0.005761686,0.016533924,0.008724474,-0.04507875,-0.042053167,0.031624522,-0.0032359716,0.051476423,0.059814762,-0.04324554,0.05190364,0.0072980775,0.08594903,0.04090619,0.013463492,-0.0015471864,0.026885819,-0.011308544,0.036805723,-0.025961256,0.101133175,-0.031474955,0.0314306,-0.07580603,-0.07476811,-0.03368632,0.047166977,-0.046041276,0.03744312,-0.039193213,-0.02301636,0.09481748,0.042638056,-0.016923461,0.06073188,0.0022124369,0.042510774,-0.11657233,0.049333762,-0.00024237567,-0.0831699,-0.008167739,0.015898384,0.02186494,0.028154565,-0.0135543225,0.025760917,0.024146518,0.004825658,0.011062636,-0.019539677,-0.0016764138,-0.113163136,0.009393282,-0.03973347,0.05626608,0.038907878,0.014577829,0.067192115,0.047173887,0.009671794,0.003116397,-0.0021919254,0.021703731,0.08586582,-0.024434866,-0.020922706,-0.0898946,-0.024241805,0.00010413117,0.010061225,-0.046031952,0.021854173,0.011797291,-0.031948823,0.0109153,-0.05718013,0.0012457217,0.016341925,0.0136917895,0.034855522,0.005969785,0.008562081,-0.0024462063,-0.0103189,-0.0025656826,-3.749908e-08,0.039267164,-0.029616976,0.08493608,-0.070647195,0.0659801,0.009123913,-0.057581555,-0.055304527,0.013366619,-0.02245642,-0.035440635,0.09357504,0.016139079,-0.048600435,0.016259843,-0.022778515,-0.088119395,0.010442907,-0.039502934,-0.010909109,-0.071588844,0.03297014,-0.120860256,0.035105463,0.022896638,0.024160508,0.005200482,0.007926761,0.043318924,-0.0127689615,0.0789631,0.06314021,0.01919079,-0.006670611,-0.1611636,-0.048135225,0.045319155,-0.05296598,-0.02842128,0.026259502,-0.0077328724,0.011442303,-0.024993826,0.023234444,-0.09475761,0.03842093,0.029573757,-0.030743549,-0.024472402,-0.011124867,0.07885224,-0.019818168,-0.04631585,-0.026048558,-0.112658545,-0.007711692,0.024540668,-0.06656156,-0.04443876,-0.033334523,-0.015343719,-0.043031998,0.18574885,-0.015313049 +1.14.13.216,"The enzyme, characterized from the fungus Aspergillus alliaceus, contains an FAD cofactor. The enzyme inserts a hydroxyl group, leading to formation of a N-C bond that creates an additional cycle between the bicyclic indole and the tetracyclic core moieties, resulting in the heptacyclic asperlicin E.",384,0.99999994,-0.038763568,-0.014009286,-0.15066925,-0.00073715165,0.014125734,-0.0007370525,-0.09000751,0.02977177,0.049786463,-0.022180645,0.08841758,-0.096260935,-0.055660848,0.07245242,-0.0689403,0.015027244,-0.047103826,-0.0055088648,-0.010292855,-0.09415921,0.06625868,0.058473814,0.03854627,0.019635815,0.012968194,-0.018491646,0.014776356,-0.06277804,-0.032188796,-0.07600668,-0.0171954,0.051225528,0.042649027,-0.0044116434,0.054152176,0.059585426,-0.008700411,0.036042675,0.09833158,0.022893636,0.0063150665,-0.06803985,0.014627201,-0.040558435,-0.046559125,-0.013046479,-0.03335542,0.028584661,0.09923186,0.0012619578,-0.031668995,-0.038019363,-0.059399404,-0.030032093,0.0064310445,0.06261652,-0.0134566445,-0.06412178,-0.019533291,-0.03210009,0.08911257,-0.0024263503,-0.039980914,0.053531464,0.0034531695,-0.040206406,0.025143363,-0.07788207,-0.023973187,0.0062220315,0.0063794814,-0.078422725,-0.009456355,0.0060007656,0.09227061,0.06273777,-0.052029606,-0.030315338,0.032041535,-0.06504525,0.03915205,0.06674243,0.09439764,0.0860796,0.034362935,-0.007482669,0.047811568,-0.019343358,0.027908634,0.02092814,0.02400651,-0.007613472,-0.028051663,-0.0668627,-0.0269743,0.053919677,0.10900342,0.05784416,0.03415988,-0.049544208,0.045343053,-0.0039026227,-0.00084058417,-0.0073882365,-0.059194535,-0.030304648,-0.0064468454,0.05321651,0.11598079,-0.01433212,-0.0445645,-0.012154763,0.072094336,-0.120120116,-0.024311313,0.02305298,-0.0089151915,0.0057033277,0.06514234,0.041510615,0.029502941,0.043936003,-0.007396512,0.13847215,0.026378574,0.017365463,-0.07532073,1.8616172e-33,0.071485855,0.058411885,0.0014824714,-0.048486065,-0.021058323,-0.045080073,-0.094547026,-0.012953514,-0.02081872,-0.1061745,-0.07418708,-0.0032501423,-0.0016843027,0.053873036,-0.035724897,-0.03929187,-0.04656444,-0.063615724,0.051111717,-0.025921673,-0.0015792927,0.10870469,-0.08142307,0.08476211,-0.013058923,-0.0140708005,0.0068201814,0.04816854,0.0026813727,0.008804131,-0.010841828,-0.04825289,-0.12802567,0.0365142,0.06280167,0.08670483,-0.013720972,-0.00055598625,-0.065616965,0.07751045,0.00923015,0.01568448,-0.029990876,-0.04645264,0.027425066,-0.061493624,-0.052123897,0.11665684,0.047003973,0.049115084,0.034183923,0.011284466,0.06876458,0.021150237,-0.06276084,0.059384428,0.0017088023,-0.006297922,0.005254563,0.020004429,0.04247618,0.0050189793,-0.057351608,0.11863286,-0.07487283,0.015487133,-0.019414587,-0.06911142,0.022137392,0.032934155,-0.08515965,0.027569838,0.02466139,0.05057116,0.03159083,-0.019008633,-0.044141594,-0.03548061,0.011115336,-0.0048658717,-0.05135092,-0.007484251,0.013249776,-0.08045323,-0.07023803,0.013936706,-0.039166525,-0.058616646,-0.018015673,0.024631316,-0.0076395343,-0.10388785,-0.026022034,0.06869378,0.090205014,-4.3500285e-33,0.07690507,-0.13391784,0.07951676,0.0006519258,-0.07303468,0.07109761,0.011659817,-0.019427318,-0.009414478,-0.044019036,0.09677738,-0.0150312865,0.064129144,0.030538082,0.019149534,0.021121304,0.00016875306,0.11158085,0.05008533,0.060756672,-0.024027882,0.039382767,0.024360651,0.009554521,0.05315354,0.0076586823,-0.07687819,0.004118178,0.016016927,0.06501096,-0.0021094277,-0.015093002,-0.033400152,0.008101269,-0.065450445,0.10701,-0.075167775,-0.02774928,-0.030138656,-0.014621354,-0.012769639,-0.016282054,0.023390086,0.055752657,0.0923921,0.043544367,-0.040998597,0.0671266,0.017550925,-0.08703068,-0.0067363735,0.021679757,-0.0013953443,-0.049218938,-0.0034555832,0.08611318,0.090322785,-0.024039876,0.016280094,-0.044523694,-0.047925755,-0.030180585,-0.0012150302,0.0057361443,0.053631704,-0.0304487,-0.035397634,-0.022511575,0.057265148,-0.06291093,0.049398404,0.015316674,-0.02856533,0.06569971,0.007232789,-0.068450384,-0.015573895,-0.00021442109,-0.024705993,0.003883934,-0.06274661,0.007872297,0.024883294,-0.028715674,-0.07894429,-0.07935237,0.06774239,0.041564662,-0.036146183,0.029861208,0.028329067,0.07564563,-0.027929123,0.047383238,0.13922848,-4.126804e-08,0.07417279,-0.006089067,0.058895893,-0.09835137,0.06848483,-0.01460024,0.05396526,-0.0777168,0.037495293,-0.056962736,-0.054106627,0.05828629,-0.029311413,0.020978488,0.010624804,-0.00045605187,-0.026160538,0.016373312,0.004945169,-0.04623468,-0.08851443,-0.050770845,-0.05479821,-0.014630277,-0.067403525,-0.032106634,0.04591442,0.05544806,0.030354086,-0.02785334,-0.043646324,0.020214954,-0.019684045,-0.08286541,-0.11029422,0.04774019,-0.035533648,-0.027214222,0.026243059,0.06097256,-0.00073937676,-0.02864713,-0.06402032,-0.028214036,-0.009327039,-0.012962016,-0.0037859224,-0.012666811,-0.03876616,-0.033103246,0.0069187568,-0.041976914,0.02943571,-0.033262134,-0.051218726,-0.021823939,0.035763033,-0.042521846,-0.028646015,-0.05709625,-0.03893372,0.027811375,0.09302803,-0.053259794 +1.14.13.217,"The enzyme, characterized from the bacterium Chromobacterium violaceum, participates in the biosynthesis of the violet pigment violacein. The product, protoviolaceinate, can be acted upon by EC 1.14.13.224, violacein synthase, leading to violacein production. However, it is very labile, and in the presence of oxygen can undergo non-enzymic autooxidation to the shunt product proviolacein.",384,1.0,-0.047160447,-0.031696156,-0.09002494,-0.018774701,0.022885626,0.08861119,-0.008733395,0.039804183,0.022593748,0.03563835,-0.010215741,-0.089505404,-0.08193037,0.0015409263,-0.10968143,0.056095332,-0.0765252,0.006053522,-0.072515726,-0.037204098,0.01930631,-0.003936478,-0.017885689,0.0033039195,-0.020597758,0.032439306,0.0072369953,0.013834808,0.10340272,-0.047543675,-0.055295493,-0.064021535,0.08905407,-0.048003744,0.06166086,0.034761585,0.011483578,-0.124739,0.011026968,-0.004696504,0.089690454,0.021669492,-0.077694975,-0.051439364,0.025043644,-0.027853908,0.06693615,0.0058341776,0.0026448444,-0.052240968,-0.042890735,-0.07785638,-0.035177976,0.01754457,-0.05455436,0.017760953,0.018853573,-0.04084266,0.072381616,0.039947644,0.026909417,0.021310937,0.06477151,-0.0030371714,-0.04160837,-0.046312444,0.022438243,-0.035956632,-0.033521324,-0.08218208,-0.05190539,-0.103680685,0.008804495,0.1014614,0.015966015,0.074106894,0.010805067,-0.034026895,0.047025092,-0.044584837,0.059615556,-0.06368246,-0.061088458,0.11741271,0.037240308,0.00053956936,0.003450566,-0.02898095,0.048871353,0.07314858,0.0019347593,-0.02773196,0.005456939,-0.10737963,-0.07313654,0.046836797,0.047677778,-0.07517172,0.10159784,0.017945064,-0.07543133,0.052021433,0.030437756,-0.0831161,-0.043955505,-0.033767946,-0.026018603,0.12602603,0.053162478,-0.01581703,0.010897685,0.0074973507,0.0034503806,-0.013376702,-0.0047177034,0.079084896,-0.0144087225,-0.042435765,0.010332636,0.0689176,0.057669576,-0.061093073,0.069228776,0.05087604,0.013283185,-0.0021593939,-0.063038476,1.23777645e-33,0.09169445,-0.012046521,-0.005365283,-0.02652733,-0.02315662,0.046204284,-0.06899728,0.032303244,-0.012254682,-0.0998398,-0.050982628,-0.10581112,0.027436933,0.04725621,0.030135496,-0.036771085,0.009108341,-0.057408486,-0.017420266,-0.006723387,0.019005995,-0.0024313855,-0.092588134,0.056682352,-0.0041696844,0.035519883,-0.01131482,0.053234957,0.006832009,-0.010091908,0.029763492,0.0130573595,-0.07955068,0.027394027,0.07891321,0.021239216,0.004237882,-0.021186119,-0.01827264,0.11083694,0.011584833,0.057981938,-0.015308317,-0.014035648,0.103334375,-0.080927886,-0.02396649,0.053957716,0.162612,0.042338666,-0.036414485,0.046709225,0.10976395,-0.06898783,0.0010758243,0.079704605,0.033727705,-0.009821781,0.036914367,-0.04762599,-0.04327979,0.0476644,-0.04604916,0.0696439,0.005071833,0.03178634,-0.006957545,-0.0830098,0.02170723,-0.04019335,-0.0640391,0.030212497,-0.032094207,-0.049641438,-0.014318907,-0.040134415,-0.052327443,0.027381163,0.045138527,-0.06386609,-0.023249444,0.01486077,-0.059626836,-0.03304909,-0.018024493,-0.035160888,-0.049476802,0.005033915,-0.029993499,-0.013750667,0.12811375,-0.022560952,-0.0889115,-0.013251388,-0.030183807,-2.2253372e-33,0.046631083,-0.010181532,0.0077715917,-0.00034886546,0.011770421,0.07644466,-0.0075033135,0.025162427,-0.07595997,-0.012064216,0.06854263,0.023023676,0.029866703,0.0059527047,-0.044435266,0.023017477,0.014348909,0.06530679,-0.0015972115,-0.027743513,-0.028585302,0.052457005,0.09107769,-0.049079508,0.048707105,-0.006587525,0.00043418177,0.06434972,0.015029049,0.04518002,0.033766445,0.0008409972,-0.057534214,-0.03428428,0.008901619,-0.008923729,0.018621407,-0.01965359,0.010261607,-0.022542153,0.0561819,0.006455241,-0.014335586,0.061703023,0.003132467,0.09216359,-0.03572003,-0.006876118,0.029018214,-0.008486501,0.016527586,0.017756151,-0.0036309864,-0.0035412842,-0.0021097115,-0.0005568988,0.038323246,0.018144475,-0.026938986,0.040844303,0.0013877567,-0.0364316,0.06868825,0.0052677724,0.047111038,0.07489742,-0.009124453,0.1303955,0.06761883,-0.10191245,0.09403458,0.0021239016,0.014364266,-0.012922905,-0.034341626,-0.05330946,-0.023872497,-0.052138347,0.0025746613,-0.042313065,0.00010188789,0.025184136,0.00077283604,-0.070770726,-0.0917441,-0.07315667,-0.02356387,0.07499821,-0.016673552,0.08058855,-0.03930721,0.012576593,-0.038530093,0.006514547,0.11400523,-3.6468986e-08,-0.011106717,-0.05033867,0.05654472,-0.026254872,0.069347024,-0.015653249,-0.014047402,-0.06104035,0.021044703,0.008586253,-0.054566536,0.016381543,0.0057590744,0.003917076,0.040431436,0.017990388,0.009582603,0.013363779,-0.050067194,0.06704962,-0.023983754,0.0074658007,-0.063167475,0.009740929,-0.0075700074,-0.10081797,-0.05504031,0.03381053,-0.041370407,0.018667102,0.024223065,0.0783732,0.023897376,-0.051236637,-0.1451042,0.0055145463,-0.05825522,-0.08975423,-0.060160447,-0.026097132,-0.0069813263,-0.016004194,-0.086873695,-0.011884381,-0.0055064233,0.029704751,0.041477524,-0.00602366,-0.039763924,-0.023558408,0.03129695,-0.08516146,0.010342767,-0.020442855,-0.08153626,0.010744882,0.07875295,-3.3341086e-05,-0.027611108,0.01623239,0.021941813,-0.0095933955,0.22202636,-0.025902761 +1.14.14.20,"The enzyme catalyses the ortho-hydroxylation of simple phenols into the corresponding catechols. It accepts 4-methylphenol, 4-chlorophenol, and 4-fluorophenol [1] as well as 4-nitrophenol, 3-nitrophenol, and resorcinol [3]. The enzyme is part of a two-component system that also includes an NADH-dependent flavin reductase. It is strictly dependent on FADH2 and does not accept FMNH2 [1,3]. cf. EC 1.14.13.7, phenol 2-monooxygenase (NADPH).",384,1.0,-0.039542712,-0.015368997,-0.09908399,-0.039929405,0.09937115,0.04921871,-0.08397456,0.049113803,0.052321907,-0.055566292,-0.011332373,-0.042510584,-0.10810624,0.029901238,-0.050042562,0.05535589,-0.09538863,0.04549705,-0.03293841,-0.0379708,0.027101249,-0.04943124,0.01711182,-0.007155688,0.0015512406,0.047415454,0.0018782134,-0.023926279,-0.030234495,-0.053344443,0.023520684,-0.02500473,-0.017520113,0.011138244,-0.025789967,0.055193502,0.032309182,-0.07547271,-0.05499383,0.005363883,-0.005908598,-0.054842062,-0.046195094,-0.024620242,-0.01528255,-0.05303984,-0.00045589957,0.065306306,0.06022299,-0.009043413,-0.07459362,0.012833454,-0.009763055,0.043462057,0.032033257,0.08656358,-0.018920302,-0.025721304,-0.09424151,0.04494298,-0.016790943,-0.06023552,-0.046994325,0.055795155,-0.005877888,-0.009937696,-0.04518759,-0.046578303,-0.014435741,-0.036425654,-0.06781485,-0.059899624,0.034687992,-0.054966185,0.0053473082,0.06379131,0.02542304,0.068754196,0.09440281,-0.046186697,0.043190464,0.016055243,0.010092231,0.080502294,0.07039271,-0.0070998766,-0.05794121,0.015522703,0.054711338,0.101045355,0.012307721,0.010195569,0.026292298,-0.020297045,-0.05552526,0.10010058,0.08202994,-0.002298538,0.003885473,-0.0104055805,0.002725495,0.059154533,0.015457651,-0.08367065,-0.08984849,0.012171419,-0.049081508,0.107573666,0.02189876,-0.016691456,0.011014281,-0.02013942,0.048191395,-0.027986702,-0.023877833,0.102606714,-0.019205702,-0.06703298,-0.09254008,-0.034230653,-0.052963726,-0.009260964,-0.0006736149,0.077508196,-0.02569342,0.015079234,-0.056919713,3.2381486e-33,0.10808936,0.067792244,-0.013342594,-0.027539685,0.00685111,0.051616896,-0.083037235,0.10492032,-0.030273488,-0.05622165,-0.00089199044,-0.045750853,-0.0029662424,-0.06760811,0.0333634,-0.07300373,-0.025667325,-0.015075904,0.033478763,-0.014466014,0.06602612,0.0041821008,-0.05895907,0.035612874,-0.015264497,0.049031954,-0.06309727,-0.0007853635,-0.0019686716,0.018460294,0.026571168,-0.112822846,-0.056211796,0.016980957,-0.06378616,-0.02458692,-0.11058454,-0.04666699,-0.0207721,0.07859771,-0.026121404,0.006293264,-0.0021169987,-0.035366837,0.077173986,-0.080655165,-0.019413397,0.115599,0.06674343,0.12098567,-0.0007763566,0.005398853,0.063989215,0.011389786,-0.050400294,0.043972656,-0.039042506,-0.018390438,0.009173533,0.008083476,0.011078204,0.068553254,0.005350333,0.030417938,-0.008558552,0.032536794,-0.021242926,-0.075936936,0.013363755,0.10501681,0.007243514,0.061710022,0.06801141,0.02206264,0.08702873,-0.037255783,0.0073476727,-0.053141665,0.022632249,0.018896872,-0.009772079,0.02623057,0.016056605,0.036189966,-0.06846944,0.04350995,0.013072692,-0.053382188,-0.02798558,0.015964149,0.016686345,-0.10216127,-0.012472996,-0.053392243,0.055671692,-2.813694e-33,0.06623511,-0.11532251,0.025475923,-0.1069214,-0.0031564066,0.049517922,0.0027066935,-0.038498923,0.029911138,0.029878879,0.051501114,0.003630346,0.053438313,-0.037981723,0.025529064,-0.013927858,-0.025222097,0.029215101,0.039695833,0.044533692,0.062170193,0.09133285,0.005506965,0.085211284,0.045841366,-0.018657684,0.0018195292,0.011115554,0.07983996,0.06931938,0.000945402,0.05593984,-0.053124525,-0.006937195,0.091268055,0.021493653,-0.08629893,0.022172147,-0.023961846,0.04767149,-0.0050839186,0.021281147,-0.042670287,-0.02371514,0.002349153,0.09728853,-0.13867305,0.009157446,0.040206823,-0.09031129,-0.018525947,0.069916375,-0.065781176,0.06501883,0.035281662,0.06185566,-0.011455285,-0.043409523,0.0097212065,-0.061931092,-0.056614682,-0.11297265,0.014227954,-0.012257249,0.045322333,0.033396084,0.004599442,0.08342164,-0.00856051,-0.01406951,0.060755167,-0.03184005,0.09150343,0.100744285,-0.0164068,-0.057389963,0.0012759384,-0.042249866,-0.019949522,-0.036481157,0.0364711,0.010729408,0.012193551,-0.09419401,-0.03177343,-0.071816616,0.04253203,0.08188229,-0.034321398,0.05784345,0.046907954,0.057145834,-0.035667144,0.026170466,0.07160014,-4.456893e-08,0.018394174,-0.10131096,0.058537494,-0.012518867,0.0043733628,0.058098916,0.037884373,-0.04471126,-0.00071757106,-0.03696816,-0.045921322,0.07425177,0.04732207,-0.008193644,0.028170172,0.026785169,-0.029743973,-0.008630595,-0.029125502,-0.010712049,-0.05052675,0.014177918,-0.10687741,-0.016081711,-0.0047592465,-0.015881509,-0.022357695,-0.016960988,0.028269712,-0.012499761,0.010796084,0.03163618,0.065913215,0.016247787,-0.102423586,0.005777337,-0.0001264802,-0.004788481,-0.10404993,0.0019824088,-0.018876703,-0.059825394,0.02737921,0.043557476,0.038008653,0.0055412482,0.052962594,-0.0053822557,0.03721074,0.0408228,0.031466346,-0.0053233686,0.03418133,-0.07749041,-0.11308209,-0.012271545,-0.01528331,-0.06006134,-0.0454122,-0.075897284,0.029795324,0.05488701,0.16383778,0.0103986 +1.14.14.21,"This bacterial enzyme catalyses the first two steps in the desulfurization pathway of dibenzothiophenes, the oxidation of dibenzothiophene into dibenzothiophene sulfone via dibenzothiophene-5-oxide. The enzyme forms a two-component system with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42) encoded by the dszD gene, which also interacts with EC 1.14.14.22, dibenzothiophene sulfone monooxygenase.",384,0.99999994,-0.14463961,0.04826793,-0.03837856,-0.02139009,0.04127118,-0.07342471,-0.044573545,0.07398004,-0.02686112,-0.020804595,-0.037081614,0.017499695,-0.043916572,0.061195306,-0.10161796,0.04356496,-0.09951334,0.0454595,-0.045427244,-0.025439885,0.05847947,0.007184846,0.0022463342,-0.065706685,0.025221275,0.0748532,0.05194273,0.049711514,-0.046910685,-0.05551455,0.052107338,-0.011316955,0.029567374,-0.03124277,0.0002711371,0.09510184,0.006726446,-0.040105723,-0.035276074,-0.009102923,0.023895986,0.05782571,-0.024660641,-0.027917169,-0.0006718544,-0.04477608,-0.022128671,0.13480066,0.055050462,-0.09260029,-0.081758,0.0009451123,-0.011260984,0.07090222,0.023941694,0.061690986,0.030905714,-0.013222047,-0.10084686,-0.09175204,-0.04317731,-0.019174434,-0.024892237,-0.027581591,0.029398724,0.034780342,-0.0048135375,-0.08660315,-0.035844754,-0.021101637,-0.13125564,-0.021450497,-0.0022904982,-0.029761516,-0.03797571,0.04916687,-0.022440974,-0.001075283,0.042917825,-0.07170744,0.06202319,0.008562476,0.08532408,0.071436755,0.02806236,0.017875822,-0.013484745,-0.045872517,0.071140766,0.06281835,-0.017358132,-0.016446825,0.023084303,-0.012920401,-0.10203687,0.054516792,0.04213334,0.14514221,0.030538019,0.01419881,0.02842446,-0.010649287,-0.05177875,-0.053418603,-0.07602222,-0.019007832,0.046950582,0.099908195,-0.043749023,-0.059530873,-0.056360554,0.041261137,0.061945193,-0.010192492,-0.06539861,0.06824565,0.025186243,-0.026142888,-0.047667697,-0.0117702745,-0.016398923,-0.02183716,-0.005504435,0.005231253,-0.008241563,0.035291687,-0.13077095,4.7003376e-33,0.009200537,0.0684575,0.046685204,-0.045062255,-0.024409305,0.015284013,-0.06764741,0.08206867,-0.048742168,-0.03884294,-0.107836574,-0.04563219,0.04045848,-0.07630581,-0.048543148,-0.02654126,-0.019680092,0.052781787,0.01471671,-0.008124296,0.0831355,0.018786075,-0.0648407,-0.058411047,0.03751127,0.0620817,-0.0134896245,0.016987735,-0.0248064,0.0011110009,-0.010992969,-0.109964296,-0.084561564,0.0016306806,0.057775076,0.019620968,-0.06951911,0.008773324,-0.023222294,0.013033901,-0.012691358,0.0086209765,-0.0671002,-0.018753292,-0.007986494,0.0033976596,-0.06383668,0.0653842,0.07785153,0.11975608,0.005255925,-0.031311605,0.0821743,-0.035820942,-0.045113303,0.02825618,0.017012633,-0.041987065,0.075784534,0.048631962,0.03333455,0.027609706,-0.111134194,0.0044278847,0.039040413,0.023019757,-0.020278037,-0.009725863,0.036123265,0.0901328,-0.046736732,0.0068022143,0.043740362,0.060569797,-0.0025747155,0.006682015,0.029345999,-0.01999775,0.05720975,0.018297974,-0.014160103,-0.0651501,-0.07173409,-0.0937261,-0.020945998,0.06560167,-0.025542745,-0.013598974,-0.056206897,0.06523875,0.08728642,-0.1436734,-0.042753283,-0.055386353,0.063132204,-4.867577e-33,0.06795499,0.007291647,-0.013204813,-0.105230145,-0.007819412,0.0006522017,-0.017534077,0.0038276094,0.068021715,0.021881776,0.045802336,-0.0026811992,0.056188673,-0.0017870201,-0.01908431,0.014034852,0.006492533,0.029199682,0.029181125,-0.002179092,0.036179792,0.09643498,-0.037233025,0.04707274,-0.081421465,-0.009820359,0.07138086,0.11944189,0.06777475,0.04586039,-0.076286234,0.073696636,-0.020595368,0.009133878,0.010166032,0.07175356,-0.11295575,0.025835259,-0.008409621,-0.002203784,-0.028628763,0.00059411634,-0.023173796,0.092898495,0.03497703,0.09263877,-0.113156,0.03080616,0.050269097,-0.052304097,0.038619157,0.049284223,-0.012899668,0.026916863,-0.009648507,0.028898716,0.019071355,0.021873996,-0.037348956,0.02106452,0.010697342,-0.04784588,-0.009963636,0.010948887,0.004178795,0.0066564255,-0.0076647154,0.026800856,0.032671608,0.00037834985,-0.005571311,-0.010700148,0.045413006,0.0111141475,-0.086053826,-0.05116744,-0.0670205,0.096133575,-0.01644418,0.05030204,0.03724756,0.0113344025,0.014038572,-0.04896278,-0.044518284,-0.07526196,0.008522435,0.07536057,-0.035354733,0.018633457,-0.0059014144,0.043391794,-0.043886885,0.09059725,-0.0031552832,-3.8380108e-08,0.014812973,-0.098089956,0.06448414,0.014344942,0.017799983,0.04108941,0.03139769,0.01648123,0.027841004,-0.01874241,0.039200664,0.13033694,0.024968483,0.021300761,0.02170295,0.052714873,-0.08012899,-0.014123497,0.018233292,-0.007907734,0.043647416,-0.017790826,-0.081648014,0.059602503,0.07312224,-0.04477414,0.04118185,-0.021153145,0.009980682,-0.062416863,0.0039055082,0.046884973,0.0028639452,-0.00071121426,-0.049799766,-0.019936187,-0.104065776,-0.0342268,-0.034831766,-0.046435826,0.031970583,0.014747029,-0.026708245,0.02791721,0.0011549277,0.05266332,0.036595512,0.04245644,0.014726533,-0.02364422,0.02721422,0.00902947,-0.032326482,-0.081743255,-0.106887124,0.04253079,0.01905619,-0.012577876,-0.03880398,-0.010554427,0.02768831,0.0062796557,0.11607034,-0.0116437385 +1.14.14.22,"This bacterial enzyme catalyses a step in the desulfurization pathway of dibenzothiophenes. The enzyme forms a two-component system with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42) encoded by the dszD gene, which also interacts with EC 1.14.14.21, dibenzothiophene monooxygenase. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.",384,0.99999994,-0.15279941,0.04279495,-0.06086704,0.01208516,0.07196307,-0.046168175,-0.027599208,0.06699079,-0.005418157,-0.034719717,-0.048118874,-0.014375055,-0.081315555,0.06484526,-0.09885656,0.033731814,-0.09193405,0.030262694,-0.058748376,-0.011119211,0.0707109,0.020420985,0.028838588,-0.052046485,-0.006908369,0.05429995,0.09685859,0.04461561,-0.008137126,-0.06343957,0.085071996,-0.008081092,0.034930557,-0.04414413,-0.0044134883,0.112611316,0.02263394,-0.06432452,-0.044997435,-0.037473828,0.029844992,0.05689649,0.015883107,-0.010540759,0.024310151,-0.037948523,-0.017969431,0.15234472,0.037133772,-0.038566172,-0.08175638,-0.015086305,-0.02537281,0.08015831,0.013707875,0.04973209,-0.014445519,-0.03234517,-0.09720926,-0.10246265,-1.4258768e-05,0.004894858,-0.047731806,-0.010535314,0.05061936,0.023937471,-0.012638854,-0.06259005,-0.01823486,-0.019654932,-0.08828929,-0.030407816,-0.003694675,-0.032096084,-0.039902803,0.024004387,-0.021334816,0.019148475,0.041704036,-0.030768873,0.07804618,0.0013318592,0.08266495,0.082399815,0.035982702,0.020207195,-0.023376184,-0.021451976,0.078880526,0.05076659,-0.031385172,-0.01756134,0.028872108,-0.0126114,-0.14381646,0.062703185,0.063189365,0.11220941,0.03867545,0.026311161,0.014345749,0.01289712,-0.015130374,-0.04664453,-0.06449967,-0.023362666,0.046714686,0.11752799,-0.034083843,-0.065551355,-0.052808933,0.021517789,0.059373535,-0.015943052,-0.064596705,0.065728284,-0.019589672,-0.060434677,-0.057819337,-0.007194238,-0.0076770284,-0.0060668644,-0.01017031,0.025697079,-0.0015449921,0.041593738,-0.15832919,1.7044266e-33,0.0511387,-0.00038106018,0.032174207,-0.04188023,0.0058012833,-0.0036538022,-0.043974116,0.06111432,-0.061299015,-0.039238043,-0.11620437,-0.029345429,0.05892747,-0.05466632,-0.03697121,-0.0438358,-0.023524499,0.031355932,0.027560076,-0.0022545962,0.09676438,0.030003855,-0.06095664,-0.043213036,0.02295156,0.074350394,-0.034663152,0.027469033,-0.004912838,0.011589611,0.0056990036,-0.10580993,-0.08623956,-0.0042521534,0.056941535,0.043149978,-0.100704916,-0.0076846974,-0.029777244,0.02323405,-0.031332783,0.00397399,-0.08683663,-0.027222123,0.031132713,-0.044588618,-0.06256038,0.063868396,0.07783407,0.09304246,0.049529918,-0.023412844,0.078370504,-0.0071845204,-0.0472841,0.053183455,0.009964812,-0.035473734,0.040346082,0.031180663,0.031431116,0.017906567,-0.09866967,0.02293862,0.024694445,0.02534566,0.017020822,-0.025176072,0.05714441,0.07303058,-0.03532768,0.0018940838,0.050089482,0.07462775,0.02135926,0.007854304,0.027649373,-0.059559897,0.034826227,0.0317613,-0.005601305,-0.048849843,-0.052258413,-0.06313751,-0.033076078,0.06940199,-0.03429511,-0.051197324,-0.055333674,0.04611497,0.08366029,-0.1453387,-0.04159076,-0.080253854,0.06474297,-2.1614199e-33,0.049131464,-0.009641983,-0.042291183,-0.08661655,-0.0058444804,0.03274828,-0.02140019,-0.0022901127,0.05161022,0.024759881,0.046904676,-0.0064931805,0.03464869,0.0027732016,0.014507981,0.036609653,0.013055076,0.026794963,0.05015511,-0.022885988,0.03132348,0.090181544,-0.0148957,0.045141622,-0.08126754,-0.015467176,0.07928765,0.09361878,0.056304853,0.070312425,-0.09636655,0.054921933,-0.037909396,0.0038456079,0.01830374,0.06900594,-0.10270801,0.030797629,-0.023508111,-0.00048671648,-0.0062527414,-0.012669676,-0.0002422761,0.08026342,0.03617406,0.10696349,-0.11693136,0.03086043,0.035006545,-0.040633842,0.03199412,0.03947491,-0.016938308,0.045600064,0.013336733,0.0239791,0.03339407,0.03715142,-0.017870968,0.030215329,0.017316097,-0.078059226,-0.004649853,0.02659841,0.03151741,0.0034719368,-0.0062506315,0.053690244,0.026206248,-0.014869362,0.019755067,-0.024440724,0.060157456,0.029704086,-0.07238806,-0.04641774,-0.088399686,0.064885095,-0.028456649,0.020711944,0.04417258,0.040688507,0.034064196,-0.06770264,-0.033120357,-0.08105799,0.012767006,0.049528614,-0.008873686,0.047888473,0.01309038,0.019405972,-0.053561546,0.0543218,0.0073056384,-3.6929606e-08,0.00010637064,-0.09619743,0.04767654,-0.0072455993,-0.0105554,0.06147094,0.045739613,0.012646945,0.0074682278,-0.031232893,0.034771234,0.11407056,0.021788662,0.020244587,0.0148417,0.04484134,-0.033923373,-0.01993884,-0.032172002,-0.04373659,0.023243068,-0.003242711,-0.0659537,0.051188983,0.039591786,-0.026306929,0.0043721087,-0.0143885845,0.040048834,-0.063169666,0.003827979,0.052965865,0.03458505,-0.0059471806,-0.1019632,-0.033932436,-0.067729905,-0.037629038,-0.057872053,-0.025140844,0.007376959,0.033917964,-0.017828235,0.012018016,0.0032381231,0.04791693,0.03541548,0.025078226,0.016062764,-0.0024221088,0.029274385,-0.010410412,-0.03388564,-0.08478672,-0.12775224,0.007864443,-0.0073126312,-0.0051621855,-0.045082513,-0.025098506,0.022096792,0.035068974,0.14456426,-0.001196519 +1.14.14.23,"A P-450 heme-thiolate liver protein that catalyses the first step in the biosynthesis of bile acids. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.",384,0.99999994,-0.048398126,0.0028039766,-0.062891364,-0.04527734,0.038076542,0.069303006,-0.054106098,0.08090137,-0.026577685,-0.02348037,-0.0051129414,-0.052783,-0.08443905,-0.016033465,-0.012463099,0.034086246,-0.05786905,0.0048904708,-0.008665147,-0.12103564,-0.002435347,0.00457697,0.034146573,-0.028389651,0.023226473,0.010059301,0.12554027,0.015384265,-0.024385683,-0.081354044,-0.045526553,-0.06932636,0.038704183,-0.056094773,-0.022053994,0.11560401,-0.069338165,-0.03410397,-0.009854699,-0.0059459,0.106598504,-0.043211546,-0.08673516,-0.04702957,-0.033489745,-0.033719126,0.0530946,0.07397943,-0.00064965733,-0.0022972003,-0.017715124,0.0003011142,-0.0329853,-0.003945323,0.009963719,0.011998003,0.04906814,-0.0320712,0.024822531,-0.10550711,-0.032164153,-0.009963805,0.022619018,-0.021712588,0.03141286,-0.056317113,0.052300617,-0.07956954,-0.015375191,-0.06728527,-0.084960476,-0.079647645,-0.03208644,0.04881059,-0.05369406,0.0760401,-0.04211688,-0.005829398,0.059429638,0.028783673,-0.004430917,-0.02276363,-0.025296906,0.110565245,0.06664477,0.028139174,-0.068876006,0.058840744,-0.05987175,-0.031567253,-0.036294844,-0.042620935,0.0021954253,0.0030989756,-0.10581155,0.07192416,0.00687792,-0.01585438,0.03973186,-0.01934938,0.050260022,0.10200123,0.0056220214,-0.07803103,-0.07647304,-0.015466653,-0.023458581,0.12566209,0.03881313,-0.057631772,0.012319682,-0.09171898,0.07890001,-0.044872597,-0.034540076,0.18214385,-0.07046757,-0.03824827,0.008695716,0.0150671005,0.0018606009,0.04313182,0.024739983,0.08800909,-0.023867209,-0.030206516,-0.11975767,7.6633236e-34,0.10383957,0.05617541,0.0013916757,-0.0009126064,-0.026264887,0.0012722388,-0.05080444,0.054648403,-0.003792454,-0.0333981,0.011299104,-0.088866785,0.06769021,-0.05427045,-0.051506273,-0.050749246,-0.05253018,0.03227969,0.010517171,0.0072394474,-0.06322647,-0.005256348,-0.019402128,0.008394391,0.09975937,0.04009538,-0.040107854,0.0075070173,0.02220396,0.024597667,-0.055325147,-0.01951117,-0.03495739,-0.020037673,0.00090677926,-0.016324814,-0.025572771,-0.017206822,-0.045096103,0.04895556,0.01051702,0.00033189083,-0.0041046077,-0.07163106,0.04206343,-0.05436539,-0.09475337,0.03420469,0.05404372,0.04677399,0.039148826,-0.0420453,0.15027301,-0.013440252,-0.031421907,-0.053855352,-0.012298986,0.046367563,-0.0017039144,0.057594266,0.11009436,0.10031216,-0.07320745,0.09339852,-0.042700842,0.012457757,-0.043645445,-0.02920425,-0.0342697,0.08126102,-0.03776379,0.020018278,0.06083693,-0.0388268,0.010789806,-0.008626573,-0.028246336,0.04244539,0.017641902,-0.022782879,-0.011815678,0.0025275776,-0.052388474,-0.0627449,-0.0038130747,0.0068816743,0.026380043,-0.05296951,-0.04434046,0.013664429,0.030931024,-0.041596435,-0.039566092,0.03153038,0.022327015,-1.0987948e-33,0.0532401,-0.07929036,0.008290628,-0.06092074,-0.02497006,0.04371825,0.05310454,-0.056900986,0.0128668165,-0.012967146,0.06720067,-0.03369438,0.049567536,-0.05563646,0.062277302,-0.018725285,0.0067411438,0.010391619,0.041175887,0.012284691,0.021567877,0.04741692,0.031723868,0.030468317,0.008304666,0.030820822,-0.012998567,-0.00935248,0.08267855,0.022367219,-0.08361425,0.04162046,-0.07110794,0.000946253,-0.06941565,0.060656656,0.0028146983,0.039043996,0.076038614,0.03633595,-0.014338535,0.044291962,0.015235703,0.04367484,0.023223784,0.08672334,-0.018797345,-0.004768439,0.026200194,-0.07120752,0.048388124,0.058657724,-0.005938953,0.04473512,-0.04140649,0.055921566,0.0015641302,0.027073907,0.037397366,-0.10105294,-0.12525703,-0.0058262576,0.059027597,0.063305944,0.00028470633,0.046408635,-0.057814486,0.06250022,0.015011732,-0.013299904,0.03478533,0.00815711,0.025996348,0.10682968,0.0027968108,-0.034094665,0.0287367,-0.0065772035,0.06041553,-0.061246924,-0.009647168,-0.00091007876,-0.022989675,-0.046293087,0.050662927,-0.061199937,-0.062836535,0.09219816,0.031287163,0.020209357,-0.062149905,0.03758346,-0.04110222,0.052872043,0.02194005,-3.3703277e-08,0.00048650146,-0.084723555,-0.013486367,0.06037597,0.072239354,0.04081437,0.02496959,-0.007979265,0.05228439,-0.042073116,-0.002485103,0.1313123,0.023935193,-0.01597862,0.04174423,0.048374332,-0.029714176,0.018843224,0.025606206,-0.034568254,-0.042231336,-0.0030472146,-0.041538544,0.012606892,0.022070693,-0.051022083,0.0061273617,-0.037560184,0.042570446,-0.00017246841,-0.047233764,0.028390463,-0.034757514,-0.02183586,0.06540734,0.027201286,-0.0713015,0.0010132737,-0.013863239,0.014422348,0.014298616,-0.04600876,-0.069928326,-0.031356514,0.0023820265,0.01238784,0.0030628846,0.039494343,-0.020154398,-0.02373574,-0.03711408,-0.010950471,0.022977935,-0.09455196,-0.09710172,0.04149802,0.07298389,-0.08620108,-0.002615216,-0.05664824,0.06683111,0.08671437,0.19278932,-0.015325462 +1.14.14.24,"A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.",384,1.0,-0.10846026,-0.0049226033,-0.086613454,-0.07372434,0.020948954,-0.013892044,-0.029418452,0.042275023,-0.016860828,0.041252773,0.0072113145,0.0040435083,-0.060118657,0.004675649,0.017867202,0.013720656,-0.00643297,0.09725096,0.007857804,-0.053398658,-0.009501073,0.03882268,0.0050370796,-0.02964332,0.1074566,0.031154707,0.105613455,-0.011030511,-0.02620182,0.023012483,-0.014602203,-0.044033382,0.06330887,-0.08472508,0.03737392,0.065478295,-0.06206657,-0.002215986,-0.12102544,0.03650457,0.0323289,0.022600919,-0.049401943,-0.03604353,-0.005583026,-0.025145411,-0.018412657,0.022030951,0.0046505854,-0.016548468,-0.051840223,-0.007568407,-0.012504397,-0.010137121,0.031576097,0.001816214,-0.019279925,-0.006177992,-0.012083175,-0.030405492,0.0036057578,-0.057254143,0.045846306,-0.034209028,0.118943356,-0.038320962,0.018839536,-0.077542365,-0.020557808,-0.11546467,-0.083863124,-0.087918684,-0.021124933,0.013555958,-0.03446355,0.0047956323,-0.00034663267,-0.020854719,0.06482959,0.011984451,0.010938466,-0.03806028,0.021566356,0.11765391,0.038447782,0.0647089,-0.060406506,0.05285739,-0.055909835,0.058502592,-0.07209716,0.02801801,-0.011524943,0.034900576,-0.11372313,0.080450624,0.02260941,0.039187506,0.04610463,-0.024996568,0.027832588,0.13426568,-0.0016800697,-0.08316275,-0.06661664,0.011844539,-0.052348636,0.0889067,-0.012109688,0.014954894,0.0011816901,-0.0077762897,-0.06384485,0.01579032,0.0017569736,0.11827394,0.061096102,-0.07551055,-0.05627264,0.013368882,0.030619819,0.032021236,0.08587317,0.0137025695,0.026198061,-0.020910373,-0.015039057,3.4669152e-33,0.01119739,0.059782278,-0.006354984,0.08438631,-0.045683373,0.05438326,-0.03755105,0.047271445,-0.011471439,-0.0844776,-0.045859598,-0.1147781,0.09229499,0.012804743,-0.03986625,-0.015792832,0.024676505,-0.038720865,0.086668015,-0.017482249,0.07577075,-0.027528502,-0.009634387,0.016384134,0.030470593,0.005680198,-0.031522952,0.08965761,0.08057086,-0.015120796,-0.025069796,-0.12629214,-0.037970707,-0.027753722,-0.015475188,-0.013367906,-0.055598076,-0.049925976,-0.039784715,0.14290975,-0.049977936,-0.030221233,0.02264324,-0.056361917,0.046184834,0.003689159,-0.08569002,0.036256038,-0.0379658,0.02093619,0.080386944,0.026731461,0.12025276,-0.05700087,-0.053582642,-0.0027399804,-0.06523444,-0.020585516,-0.021089217,0.04898458,-0.019703401,0.05675521,-0.041526094,0.115872495,-0.012145006,-0.00082137744,-0.07076671,-0.027884841,-0.12351311,0.07399218,0.014490534,-0.013509306,0.10792043,-0.029381894,0.031258125,-0.039045785,-0.038143262,0.026683934,0.040715836,-0.07376322,-0.040746678,-0.017003343,-0.040405456,-0.004664428,-0.0005853569,-0.01996625,-0.0316493,-0.10664477,0.012344438,0.010740646,0.038662177,-0.10459725,-0.05521174,-0.019664036,0.039807465,-5.8711278e-33,0.031097252,-0.020387786,0.016623925,-0.080095455,0.036563028,0.06559893,0.03145093,-0.011126808,0.053966817,-0.0108372765,0.0072178156,-0.027370078,0.033847637,-0.045447256,-0.0049882107,0.009959766,-0.012177154,0.05376402,0.006915646,-0.009240336,0.047182124,0.012415354,0.018005215,0.04219541,-0.025672333,-0.007124345,0.0014939106,-0.008886947,0.032193612,0.08370034,-0.022519367,0.031598404,-0.05950322,-0.0021230266,0.013815098,0.08661326,-0.05459449,-0.029768752,0.025258575,0.033961263,-0.06487116,0.016210107,-0.022766618,0.055723924,0.029569892,0.05654662,-0.0051184357,0.0369993,-0.015161036,-0.0009813067,0.034380134,0.05816209,-0.0076061124,0.046550438,0.013370321,0.088708825,0.09126419,0.029269064,0.078100204,0.009225358,-0.047822755,-0.10043934,0.020352406,0.056646638,0.0137923835,0.026308002,0.019969098,0.14735049,-0.059433013,-0.00011385519,0.09181578,-0.021192761,-0.016202081,0.019458765,-0.030352926,-0.06603179,-0.016945185,0.059076235,0.015368983,-0.03059665,0.054786436,-0.056698244,0.025977006,0.014708726,-0.019742882,-0.15689135,-0.000109593806,0.10111137,-0.09168542,-0.036648367,-0.06338553,0.028743804,-0.08430542,0.04158125,0.093079805,-4.6742397e-08,0.077709764,-0.015004425,-0.028153505,-0.038009558,0.022905111,0.02493063,-0.046355464,0.028540395,0.045842454,0.026392352,-0.039198767,0.08897614,0.00334457,-0.017428897,0.06511977,0.055301983,-0.052878276,0.013224399,-0.022350876,-0.013367807,-0.037936077,0.045691337,-0.121458046,-0.011784384,-0.010923967,-0.055275504,-0.034023453,0.016160011,0.03975698,-0.034699872,0.020334154,0.018377654,0.014477973,-0.015215195,-0.039081052,-0.06935564,-0.0017640286,-0.028154321,-0.0017021886,-0.0059129777,-0.06549309,-0.09160467,-0.05947914,0.015512993,-0.06915218,-0.0138982395,-0.03195535,-0.019918498,-0.05138801,0.0113211125,-0.044963796,-0.01688752,0.025367826,-0.07996902,-0.029257294,0.061905738,-0.03562741,-0.05749748,-0.02211868,-0.091272466,0.031510465,0.040401604,0.07223619,0.019848643 +1.14.14.25,"A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood---brain barrier whereas cholesterol cannot [3]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase [3].",384,0.99999994,-0.06809956,-0.0059590335,-0.05688809,-0.042442072,-0.004238152,0.0147096375,-0.04210505,0.09368339,-0.030933596,-0.021737225,-0.050556533,0.02060787,-0.07358516,-0.02138613,0.0002990269,0.05508281,-0.034391984,-0.021380516,-0.01352007,-0.037327852,-0.0076535856,-0.0047215004,-0.026090434,-0.0101326,-0.034059856,0.047101438,0.0830079,-0.04355585,-0.07327777,-0.06897855,0.014044385,-0.05032239,-0.039515123,-0.036269896,-0.029813776,0.10147847,-0.097374365,-0.04151546,-0.027664112,-0.054760657,0.09237418,-0.09127316,-0.07535653,-0.0021830199,0.008636297,-0.046718135,-0.000667109,0.06977846,0.014322427,0.01833179,-0.06384324,-0.019552499,-0.054441024,0.027420977,-0.02498537,0.016665237,0.029640514,0.035862666,-0.04001987,0.0034550752,-0.05547904,0.007112324,-0.008366509,-0.014290814,-0.0018679422,-0.07994711,0.029529706,-0.08589265,-0.053821106,-0.032028742,-0.02372879,-0.06340392,-0.019880578,-0.011657312,-0.007694372,0.037706636,-0.07034699,-0.05433728,0.06137862,-0.0408649,0.048902694,-0.0285807,-0.026799735,0.12400768,0.09800683,0.032526627,-0.045149364,0.09754067,-0.06750693,-0.006664744,-0.00320457,-0.018031836,-0.015954534,0.0433643,-0.116148494,0.037385017,-0.014804513,-0.007275861,0.005918573,-0.021766813,0.039598648,0.06431819,-0.0070424452,-0.0712027,-0.09344184,0.019614983,0.03799696,0.04535049,0.0136186415,-0.0096207885,-0.021736344,-0.03619134,0.055286568,-0.0065255077,-0.0039933077,0.13247,-0.03742818,0.002574972,-0.025683349,-0.05414672,0.03891583,0.009669164,0.047777142,-0.0008256838,-0.021717172,0.00068238005,-0.060502376,2.3424677e-33,0.054142028,-0.031652823,-0.022605969,0.01886468,-0.02213526,0.05949754,-0.04829309,0.05545495,-4.0920757e-05,-0.018340599,0.01642699,-0.14182122,0.061912663,0.008582631,-0.030341547,-0.03713166,-0.029528376,0.053843368,0.04541193,-0.00586995,-0.039857484,0.041859493,-0.065120414,0.04166925,-0.012714401,0.0429492,-0.03974509,0.050033133,0.024187125,0.031076375,-0.0631008,-0.061287798,-0.06737856,-0.06434172,0.024890073,0.04225728,-0.026016962,-0.004727742,-0.048880026,0.060476385,0.0040922444,0.009495594,0.012533641,-0.06706654,0.06544066,0.008518645,-0.020808548,0.0233302,0.0052910633,0.017377993,0.0003566084,-0.059874516,0.09761947,0.046825957,-0.0057719448,0.022866929,0.020869061,0.07946157,0.048244495,0.050706953,0.10000772,0.1349927,-0.07878626,0.01569165,-0.031731885,0.03056353,-0.027645512,-0.03395682,-0.055432085,0.1285095,0.049529027,0.05484058,0.036262836,-0.03653947,0.025787624,-0.02020977,-0.006709065,0.10344003,0.060169265,-0.048033033,0.051473323,0.011021925,-0.012207881,-0.059842464,0.006765121,0.06730686,0.039766688,-0.011386707,-0.034932937,0.00252179,0.109364234,-0.11958221,-0.018551938,-0.0706121,-0.021564018,-2.1465686e-33,0.0057747182,-0.05661468,0.02715221,-0.08404004,-0.0023663915,0.07386978,0.07535348,-0.0055149193,0.022509262,-0.03871902,0.065267384,0.024251014,0.026956344,-0.0596795,0.07716688,-0.0018508148,-0.106095135,-0.0360278,0.012076132,-0.028454369,0.016011767,0.07842717,0.03713491,0.12583601,0.0017657839,0.002375843,-0.015842885,0.0033298933,0.15166286,0.021969311,-0.07473646,-0.00016161111,-0.09531883,-0.02196114,-0.059852492,0.06477431,-0.033132836,0.027411083,-0.020807197,0.010233997,-0.052947782,0.031184442,0.06705022,-0.01831669,0.02679026,0.114321485,-0.059421703,0.002363443,0.0072020423,-0.01794787,0.025482727,0.05643717,-0.014734072,0.033665955,-0.02099322,0.00047155697,0.020063324,0.020604895,0.049502008,-0.13373649,-0.09374362,-0.032746065,0.029251885,0.04940994,0.01658792,0.076790266,-0.023204254,0.06305856,0.016827391,0.0052957432,0.025835665,0.060745437,0.019707622,0.058973603,-0.0020445602,-0.014716936,-0.0018275038,0.00976306,0.0358211,-0.01827705,0.010596285,0.024128716,-0.044148978,-0.08636476,0.03678712,-0.087812744,-0.057396393,0.02976725,0.04122704,0.018646933,-0.037533894,0.03962747,-0.08461711,0.028772745,0.033007447,-4.4146258e-08,0.0064188996,-0.11402365,0.016137145,0.013287365,0.024084186,-0.0077509065,0.053317487,0.038196262,0.08496865,0.0046727173,0.012746355,0.1232657,0.01158989,0.04378571,-0.022569645,0.031369183,-0.0051344656,0.029482268,0.036829542,-0.051929332,-0.001209451,-0.0057829474,-0.036667347,0.046896767,0.007989663,-0.008160771,-0.024643928,-0.056801986,0.029641725,-0.0583272,-0.011663592,0.035579428,-0.0049683983,0.040522777,0.05141785,0.019523306,-0.040723667,0.041713644,-0.035358842,0.076005206,-0.014948329,-0.08497957,-0.04682721,0.007897967,0.027575238,-0.011729207,-0.005644373,0.036390334,-0.009375192,-0.04493017,-0.023604592,0.022616398,0.0056889565,-0.10855111,-0.108086124,0.013717922,-0.00345469,-0.053092316,-0.0126468055,-0.09487345,0.07276019,0.0583158,0.22992317,0.038580507 +1.14.14.26,"A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.",384,1.0,-0.035751555,-0.031127091,-0.05711433,-0.036743335,0.028222494,-0.0064375494,0.0075517287,0.10597043,-0.0015449675,0.008213456,-0.007933792,-0.04230896,-0.095566005,0.017469017,-0.020686327,0.009601194,-0.06253681,-0.03232512,0.024006762,-0.11194171,0.010693266,0.029256718,-0.01007941,-0.03175832,-0.0075105308,-0.002625159,0.120035,0.018151904,-0.04210915,-0.079618566,-0.035713006,-0.024219932,0.029744681,-0.004789148,-0.027366808,0.08730617,-0.10469688,-0.04686515,-0.014215647,-0.054038707,0.09506348,-0.035155613,-0.0493304,0.020971805,-0.024810351,-0.05533633,-0.04405516,0.06635317,0.008947351,0.022681834,-0.05096863,-0.05596502,-0.021876806,0.048497077,0.019805267,0.027236411,0.020202298,-0.0096224565,0.013397182,-0.06885458,-0.021518547,-0.0040472643,0.024021612,-0.028951995,0.012984952,-0.0075741936,0.050391544,-0.06377318,-0.05246401,-0.09979367,0.001980329,-0.06955009,-0.031451806,0.047984667,-0.02430418,0.07672048,-0.048877973,-0.020463107,0.026488116,0.00010713498,0.032800242,0.042632975,0.04295456,0.091307685,0.117400125,-0.0042020218,-0.045067485,0.06495353,-0.06654635,-0.0556302,-0.02524546,-0.0056234845,-0.11107993,0.0009332948,-0.09688667,0.028279122,-0.014590263,-0.010681725,-0.01200993,0.0026753962,0.064579174,0.05865924,0.004744399,-0.06430351,-0.11527929,0.030772446,0.026059689,0.062255178,0.028831447,-0.05061012,-0.023598114,-0.02416273,0.056089398,-0.035128895,0.029249,0.12766032,-0.0566984,-0.026813224,0.07152593,-0.008842577,-0.020226408,0.058086365,0.037384022,0.001789245,-0.04293288,0.052679747,-0.08596256,1.0269735e-33,0.06655119,0.000913457,-0.0025465216,0.035804436,0.0192129,0.06447385,-0.039127663,0.07667764,-0.036463372,-0.0908131,0.006477282,-0.100013584,0.048952024,-0.012717244,-0.022028841,-0.031882245,-0.0104709985,0.03276112,0.042373158,-0.010597436,-0.048687108,0.04081785,-0.07107329,0.01523151,0.018034838,0.039968602,-0.01945307,0.024197716,0.0897473,0.02930405,-0.061222732,-0.012531155,-0.0069085425,-0.04124732,0.0024104805,0.0347551,-0.036784906,0.028117146,-0.08036754,0.07164376,0.09502671,-0.0053222254,0.021495128,-0.11018809,0.025258016,-0.061540525,-0.06686677,0.008686502,0.0071718306,0.014299296,0.025243085,-0.01902562,0.11168146,0.0062445956,-0.0011723882,0.013084358,-0.019976998,0.066855,0.05844215,0.022388639,0.12163602,0.07853468,-0.06603979,0.0669235,-0.028884642,0.061189972,-0.10839557,-0.046015035,-0.081600286,0.11804388,-0.006984896,0.055366967,0.07398556,-0.04420259,-0.005750141,-0.03969586,-0.028641963,0.071142495,0.005544855,-0.048851516,0.03303825,0.001418585,-0.03761264,-0.052017845,-0.008766857,0.008351334,0.025794819,0.0042174575,-0.056737013,-0.015346381,0.05647965,-0.055732112,-0.07758859,-0.00018468438,-0.022956742,-1.2646031e-33,0.012601919,-0.08240961,0.07072365,-0.04700673,0.009883283,0.08052359,0.085249856,-0.01905691,0.074144386,0.0020192787,0.1157998,-0.0016625882,0.018493116,-0.092115685,0.10023784,0.037977144,-0.08468914,0.0019322796,0.038421866,-0.023358835,-0.007554065,0.070701905,0.033019204,0.08253088,0.010293914,0.030299863,-0.009021568,-0.010190586,0.036513504,0.01900267,-0.07336995,0.025123885,-0.07033345,-0.0059592566,-0.10242757,0.0010494334,-0.013517608,-0.036419895,-0.02041023,0.025062839,-0.06178465,0.062213972,0.06348525,0.07591425,0.028400172,0.11674388,-0.02021017,0.0056210067,0.017330594,0.014518681,0.012813962,-0.00079186173,-0.047136545,0.03657046,-0.031446394,0.039395064,-0.009960106,0.05864353,0.03461913,-0.09000873,-0.076814145,-0.015176364,0.0012127553,0.06339674,0.04483481,0.041170586,-0.055442356,0.07702647,0.024064977,0.020253502,0.01533186,0.03917946,-0.03489287,0.058200315,0.014894387,-0.018415596,-0.021717127,0.051825892,0.03973074,-0.02092096,-0.015561819,-0.031387027,-0.030019464,-0.028639661,0.032564647,-0.12547746,-0.057873014,0.07850428,0.03685785,0.028532833,-0.06585529,0.043201525,-0.080683805,0.015276251,0.057766926,-4.6515773e-08,0.05903786,-0.12453123,-0.05585736,0.018425869,-0.0017396394,-0.0326914,0.056484167,0.04648943,0.057930116,0.010799378,0.0041363873,0.07779492,-0.036281057,-0.011477155,0.032009292,0.06189703,-0.013149512,0.028146632,0.01995153,-0.031700715,-0.00033352166,-0.004759669,0.002913263,0.03723568,-0.0016374311,-0.0061773113,-0.019286761,-0.016415397,-0.03518443,-0.042222522,-0.031011755,0.04688313,-0.020544808,-0.014285926,0.02341095,0.04188611,-0.047847886,0.032525476,-0.048076455,0.06532276,0.021972956,-0.0712205,-0.050437715,-0.052304376,-0.0070664794,-0.013132371,0.025160288,0.069658466,0.011880851,-0.0541708,-0.10531085,0.0035184198,0.010395438,-0.034572233,-0.09258623,0.0022344734,0.022707403,-0.045033317,0.00954032,-0.09921313,0.059251264,0.05611733,0.20234154,0.023296252 +1.14.15.15,"This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-ene-3beta,7alpha-diol, 7alpha-hydroxycholest-4-en-3-one, and 5beta-cholestane-3alpha,7alpha-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase.",384,1.0,-0.06566659,-0.014503429,-0.056631178,-0.03397168,0.021633836,-0.0028443295,-0.08540832,0.014198046,-0.009428456,-0.024365202,0.041634746,0.01855385,-0.05851825,-0.0058190147,0.0016127237,0.02360561,-0.0710715,0.012169,0.025155855,-0.04161401,0.03727396,-0.04949875,0.046676315,-0.051141944,-0.006608785,0.041754127,0.07924446,0.04866091,-0.050783116,-0.06683898,-0.03599467,-0.05312684,-0.013064449,-0.038364418,-0.08777109,0.09652225,-0.077705055,-0.0013165104,-0.024454992,0.018767273,0.0667569,-0.025784394,-0.041188713,-0.03697058,0.015047438,-0.11861142,-0.023534099,0.043586757,0.042609617,-0.021566274,0.016815204,0.00041416349,0.021155901,0.011147406,-0.016820375,0.051134955,-0.01124376,-0.07088438,-0.003865872,-0.04898601,-0.03966937,0.030674808,-0.03848855,-0.014290702,-0.030839443,-0.042280562,0.039845668,-0.06756753,-0.011240965,-0.06368517,-0.07234736,-0.06514568,-0.068148,-0.015911452,-0.062467463,0.06489252,-0.048801135,-0.08815449,0.029144734,-0.038214874,0.02612698,-0.025476435,-0.051575452,0.12576516,0.13116308,0.029647192,-0.04734304,0.018845519,-0.06934347,0.035107642,0.0098937275,-0.011904928,0.0031541747,0.07317992,-0.054451223,0.042355012,0.047623657,0.0584932,-0.04575359,-0.034899853,0.04991796,0.11922341,-0.028611163,-0.05790287,-0.007468787,-0.013074547,0.028589947,0.08171551,-0.0064750174,-0.019310532,-0.0060408255,-0.07082116,0.06768377,-0.067072205,-0.015460114,0.16318166,-0.06104992,-0.04084168,-0.0554249,0.028067544,0.0028662463,0.028566787,-0.028319638,0.04033308,0.007511909,0.03494607,-0.02939158,3.827787e-33,0.110748604,0.006991636,0.007957249,0.06790483,-0.001534264,0.069730036,-0.0644976,0.0135432165,0.010324695,-0.07043653,0.021500928,-0.048170432,0.018357988,0.0049738726,-0.059047557,-0.021267444,-0.007634671,0.018447623,0.07840589,-0.023230158,-0.020931592,0.02506925,-0.059966113,-0.05639644,0.013089718,0.024363365,-0.060479935,0.066375084,0.0012730429,0.030288307,0.0007820225,-0.08191201,-0.08220572,-0.0066750282,0.018389849,0.055965208,-0.048994686,-0.01479994,-0.048418194,0.09055453,-0.005391524,-0.02471425,-0.005974254,-0.02689054,0.03794531,-0.00598436,-0.04452368,0.04045947,0.0735507,0.096909486,0.051239286,-0.023429725,0.07216666,0.045694094,-0.044832833,0.014735899,-0.012920806,-0.001040824,0.0016378186,0.07674243,0.10106236,0.12107507,-0.03711138,0.076986715,0.022883732,0.061017472,-0.03527047,-0.11083992,-0.11846022,0.08606786,-0.05536223,0.024675576,0.053186838,-0.0012283417,0.032340743,0.07943664,-0.0001741113,0.08066493,0.0063241045,-0.042566303,-0.023775993,-0.03441066,0.005779398,-0.015813585,-0.008552388,0.042719785,-0.01030102,-0.054916304,-0.0014346611,0.0025654878,0.03464173,-0.06728037,-0.03782677,0.0024842913,0.009777263,-4.304207e-33,0.020239606,-0.051817764,0.05620615,-0.12612832,-0.061744418,0.07822362,0.033678412,-0.040387962,0.0687814,-0.01818944,0.033420157,-0.0013693286,0.00972305,-0.033321768,0.054691374,0.0042172056,-0.035832,0.0152220605,0.0075673526,0.013040191,0.012601879,0.1199685,0.029950332,0.15283188,0.058343112,0.019153476,0.056514386,-0.06301685,0.09260788,0.009275671,-0.01898597,0.006549672,-0.037144642,-0.011260255,-0.077980384,0.044022802,-0.05718229,0.023102678,0.033682402,0.03268023,-0.03359534,-0.003967073,0.0039051885,-0.05000601,0.037427466,0.031243635,-0.06506114,-0.01399879,0.032411087,-0.045172673,0.035470773,0.060823787,-0.0147437155,0.042697743,0.07570261,0.066272065,0.015313881,0.03357064,0.11394216,-0.14291541,-0.07918955,0.046819966,0.020354496,-0.028451728,-0.015575155,0.034757484,0.020355694,-0.048930716,-0.0070596864,-0.030439824,-0.0065208436,0.043890595,0.04923329,0.048658855,-0.018599974,0.013513296,-0.0021254404,-0.027080096,0.017871514,-0.060682293,0.016355285,-0.0320786,0.021274868,-0.055122048,-0.04370003,-0.068396956,-0.03489808,0.04694287,0.04559898,-0.026195863,0.025257818,0.014875948,-0.06496759,0.006096419,-0.004013831,-3.9971585e-08,0.052057113,-0.03933498,0.045675196,-0.012337134,-0.026419181,0.005994417,0.10819102,-0.043187723,0.07152927,-0.050028685,0.025075216,0.1698726,0.061555546,-0.042641092,0.008168371,0.044064883,-0.029128144,0.0043519093,0.009197402,-0.049749404,-0.062081926,-0.03349125,-0.04163476,0.026456863,0.07024802,-0.045986146,0.05076292,0.019114304,0.044563506,-0.042080123,0.03405493,-0.029726474,-0.026171269,0.012474833,0.03430753,0.02871656,-0.04450843,-0.023190448,-0.018581988,0.06606987,-0.058977854,-0.111396216,-0.013742373,-0.0073787,0.008539763,-0.003361132,0.00077742053,0.046157558,-0.0061628367,0.011458666,-0.04830758,-0.0056984755,0.03461401,-0.10083835,-0.101517886,0.02283429,0.021772314,-0.08900819,-0.029370924,-0.05400246,0.05844653,0.058820873,0.16592337,0.046257045 +1.14.15.16,"This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase.",384,1.0,-0.06320636,-0.040660422,-0.04055959,-0.025923261,0.062250234,-0.025109997,-0.04684412,0.018624537,-0.009301046,0.0076050176,0.028112227,0.016788263,-0.032964103,0.016205199,-0.00385889,-0.019304393,-0.07506613,-0.02297869,0.009300606,-0.0006139535,0.045973487,-0.030430244,0.045380265,-0.034657195,0.01948164,0.007197197,0.061573934,0.042836268,-0.032587502,0.027747447,-0.03225339,-0.05404403,-0.046698723,0.008885566,-0.050553713,0.13455054,-0.111872666,-0.034984183,-0.074080154,-0.019279845,0.06920905,-0.06442958,-0.050848264,0.046493918,0.012312069,-0.09924251,-0.029866483,0.04302999,0.05202869,0.024514271,-0.04637247,0.026569473,-0.009402014,0.011755183,-0.027918255,-0.027928548,0.046548802,-0.030021783,-0.0035462265,-0.013729408,-0.015865533,0.007228926,-0.059546784,-0.02674605,0.084744036,-0.012929438,0.04726275,-0.08242772,-0.022785075,-0.068212874,-0.0153491935,-0.06711321,0.024089849,-0.014089807,-0.09460046,0.010226445,-0.045195155,-0.06620083,0.030445652,-0.015808908,0.04246471,-0.026109964,-0.08799768,0.13364053,0.10528855,0.04435141,-0.020950526,0.054046646,-0.03311806,0.062141202,-0.04901408,0.030473854,-0.06642984,0.028648572,-0.11640892,0.036788315,0.016220251,0.02347091,-0.051089615,-0.04350877,-0.002457186,0.13588372,0.00785935,-0.07317899,-0.030999511,0.013064155,-0.01231236,0.094593175,-0.045058373,0.017761732,0.022407634,-0.007853498,-0.039848447,0.010626777,0.017078659,0.16886367,-0.030991612,-0.034412477,-0.057142805,0.011974223,0.0033079016,0.010195454,0.028448792,-0.0044899676,-0.022740036,-0.016393282,-0.00792956,4.423416e-33,0.070699595,-0.0067292056,-0.035341486,0.07110554,0.003803946,0.096432984,-0.098330565,0.041996628,-0.0036654249,-0.056416493,-0.0201591,-0.035775095,0.03734661,0.03213206,-0.05311805,-0.046033256,0.0063115745,-0.039142214,0.10694545,-0.0009506559,0.0480433,-0.015107902,-0.024783704,0.005752404,-0.02827595,0.06405983,-0.0868771,0.15163013,0.017467847,0.021900032,-0.0005789549,-0.15218931,-0.07730033,-0.027245143,0.02004892,0.04216083,-0.047346123,-0.025191568,-0.018763194,0.11414056,-0.02416476,-0.031556133,0.052395787,-0.021837844,0.034828875,-0.010736364,-0.03885754,0.05076152,-0.015468785,0.075995944,0.045816414,-0.037717577,0.07451714,-0.0022227964,-0.079954326,0.008248435,-0.034478925,-0.018234305,-0.03672904,0.07411566,0.10136385,0.034333598,0.022192918,0.096445665,0.026351852,0.04357051,-0.032063797,-0.07028739,-0.051973008,0.08208221,-0.07053048,0.030080948,0.10833736,-0.037276756,0.039251395,0.0501911,0.02490767,0.04702332,0.030181108,-0.033580657,-0.018671451,-0.003009071,0.007865671,0.06766859,-0.007184475,0.07260979,-0.029952506,-0.018536443,-0.015381394,-0.034883793,0.055169154,-0.12173831,0.018860096,-0.04349738,-0.014084613,-5.2067575e-33,0.028982436,-0.03371208,0.0895299,-0.124136984,-0.02594142,0.05150542,0.07624276,-0.01694547,-0.007558984,-0.008085241,0.06799371,-0.04300785,-0.030609524,-0.043750215,0.016443163,0.07549683,-0.02927136,0.01756921,0.040898263,0.01105202,0.03814761,0.10510202,0.060049057,0.09460791,0.04536076,-0.022039095,0.032130968,-0.083251566,0.0690712,0.01958325,-0.03768661,0.027052218,-0.04372017,-0.010563806,-0.009956322,0.08994578,-0.043899916,0.021209342,0.026094444,0.081248455,-0.037194803,0.032219388,-0.032308746,0.008247318,0.019779986,0.035090927,-0.07443495,-0.05170168,-0.028559541,0.00512949,0.0691106,0.04139193,-0.060964733,0.004633238,0.04405128,0.048999216,0.03717668,0.06579415,0.07165995,-0.06550055,-0.06783851,-0.023622481,0.0026718297,-0.007964188,0.023765363,0.01449549,0.000769062,0.05902259,0.0046057557,-0.0067093037,0.052858032,-0.01639173,0.03206223,0.032290615,-0.055238646,-0.013387376,0.012837115,-0.0045933127,0.04759605,-0.06525651,0.016703155,0.015613784,-0.05753499,-0.02341103,-0.052615955,-0.08379215,-0.0041116974,0.025755469,0.013364172,-0.00030142887,-0.010078264,0.014579188,-0.05621024,0.030851306,0.057492312,-3.9849088e-08,0.03846846,0.00027090503,0.029188497,-0.012069011,0.060631208,-0.0038029444,0.049328934,0.010105368,0.060258828,-0.033429876,0.0063485336,0.11711639,0.008810774,0.011193371,-0.029743925,0.015711512,-0.034764126,0.032959074,-0.0217934,-0.018711478,-0.01370222,-0.019632105,-0.10833101,0.0069075236,0.04023072,-0.07691948,-0.03923167,0.021206172,0.011301019,-0.046700425,-0.0025927376,-0.03172879,-0.046194367,-0.05395757,0.0026894293,0.04431504,-0.035981692,-0.02391444,-0.043251645,0.057494238,-0.08748152,-0.14105473,-0.009760937,0.03076399,0.029570524,0.0068131215,-0.051381964,0.022496186,0.0037778548,0.044418547,0.0152152935,-0.005024993,0.013064599,-0.1364301,-0.13525969,0.026652308,0.0048847003,-0.07772833,-0.052102767,-0.09503921,0.05227387,0.06758412,0.11307367,-0.03937277 +1.14.15.17,"This enzyme catalyses a key reaction in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The enzyme from Arabidopsis contains a Rieske-type iron-sulfur cluster [2] and requires reduced ferredoxin, which is generated either by NADPH through the pentose-phosphate pathway or by the action of photosystem I [4]. While still attached to this enzyme, the product is rapidly converted into primary fluorescent chlorophyll catabolite by the action of EC 1.3.7.12, red chlorophyll catabolite reductase [2,6]. Pheophorbide b acts as an inhibitor. In 18O2 labelling experiments, only the aldehyde oxygen is labelled, suggesting that the other oxygen atom may originate from H2O [1].",384,1.0,-0.014864611,0.005486237,-0.11504771,0.012601708,0.18723671,0.08022158,-0.016873447,0.0101652,0.08338132,-0.016850885,0.04517852,-0.0015443254,-0.065054104,-0.041644987,-0.018866953,0.123888515,-0.12590349,0.022936184,-0.079076126,-0.058259107,0.063270874,0.0028985834,-0.03270757,-0.009100625,0.019881403,-0.0010429295,-0.029386034,-0.047205113,-0.05545855,-0.09785954,-0.017326232,0.035824344,0.045878395,0.021669978,0.01584451,0.1004321,0.027375158,-0.14716041,-0.0057227337,-0.010774411,-0.027248718,0.003634416,-0.065341905,-0.021317985,-0.099697486,-0.0023423624,0.03205065,-0.00057634426,-0.00486892,-0.03700549,-0.03500004,-0.027702052,0.00295189,-0.0041885884,-0.032965396,-0.0012051676,0.021103788,0.009122446,0.04267208,-0.033042554,-0.028851736,-0.057930227,0.007885059,-0.0015885277,-0.025544694,-0.0003355052,0.0012517504,-0.11196917,0.024468103,-0.09638452,-0.070023015,-0.0024929792,-0.026147489,0.0092844,-0.0014575731,0.06266244,0.015022998,0.027109478,-0.007088279,-0.0106438175,0.022943936,0.04320516,0.024541393,0.088953674,0.08942615,0.001286311,-0.042088103,-0.026510913,-0.019557519,0.013829754,0.020327646,0.036051575,-0.021264354,0.049792346,-0.106962785,0.11124348,0.010021658,-0.054522686,-0.00925416,-0.015872587,-0.033913534,0.08088453,-0.08806554,-0.080303125,-0.01826621,0.015407608,-0.045623936,0.06308669,0.0031433806,0.00034823085,0.013882782,-0.019944973,0.0112963645,0.030804284,0.033696845,0.07788951,0.031090435,-0.03723819,-0.06549493,-0.0015479435,0.017490275,-0.00396836,-0.04857647,0.053660836,-0.051244143,0.026622165,-0.1272223,6.110399e-33,0.08224481,0.033274725,-0.03459588,0.020899087,-0.027551873,-0.055104937,-0.09575217,0.029506275,-0.02118175,-0.10336239,-0.035782084,-0.069340326,0.010498298,-0.11401301,0.022083689,-0.07066368,-0.00650802,0.010942608,0.045084212,0.014731703,-0.017200828,-0.000658474,-0.05328461,0.005535741,-0.016080411,0.052850753,-0.032801747,-0.024066763,0.048710577,-0.0448523,0.076710306,-0.015828976,-0.0668025,0.03380953,-0.0031965778,-0.059141956,-0.03227013,0.007162609,-0.041159887,0.06019194,-0.078215696,0.07517142,-0.018003037,-0.008245849,0.13081276,-0.06269595,-0.063448116,0.09166769,0.067713134,0.08678921,-0.033403814,0.014166198,0.12214912,0.052810837,-0.059339114,0.02095871,0.0053236443,-0.06918441,-0.032729715,0.056064226,0.035572886,0.08448354,0.028020028,0.054625303,0.014996968,0.059175815,-0.013486894,-0.04128795,0.0007137777,0.10976609,-0.017567253,-0.022101028,0.0500374,0.061471526,0.060784824,-0.09032872,0.01377033,-0.020785278,0.016081352,0.01969211,0.047627453,-0.038516242,0.00067542616,-0.037207607,-0.08288566,-0.042087924,-0.02074484,-0.073128045,-0.014514449,0.028436614,0.04529799,-0.03457425,-0.014771691,-0.031144168,-0.030180803,-4.7022724e-33,0.081210315,-0.06553109,0.027051365,-0.053603433,-0.06398346,0.016713835,-0.041094646,-0.021752298,-0.014607961,-0.007595917,0.05141998,0.036437515,0.008082688,0.01609473,0.04786196,0.014034458,0.021656366,0.06663063,0.001616952,0.038986668,-0.019379133,0.102016,0.026493363,0.033658653,0.09161184,-0.009395262,0.026257126,0.05000203,0.087980695,-0.05313574,-0.021124365,0.010886277,-0.0054659913,-0.013487985,-0.008567653,0.03329498,-0.079796016,-0.038198765,0.036151957,0.090936214,-0.00037893487,0.00904458,-0.024271429,-0.010531124,0.02180474,0.009576558,-0.11223616,0.085015215,-0.02569942,-0.028811207,-0.016101386,0.06848755,-0.047206543,0.0368734,0.031100443,0.02428166,0.013009137,0.04919442,-0.049295515,0.016871618,0.009215303,-0.053884104,0.0045305756,0.027921898,0.033572238,0.02495504,0.026462225,0.06742644,0.008016786,0.10822956,0.0976998,0.038148038,0.060611315,0.062307373,-0.010339113,-0.047386486,-0.028563784,-0.012988465,-0.08094871,-0.03378104,-0.038357504,0.061107524,0.029577704,-0.06463767,0.021865396,-0.08811291,-0.031268958,0.04579271,-0.012209435,0.017916692,0.025970886,-0.06794337,0.044033445,0.053821974,0.051155746,-4.5234827e-08,-0.02609851,-0.03285393,0.027807074,-0.056212265,0.054831628,-0.01281078,0.065161735,0.001932216,-0.019092644,-0.022176402,-0.038583983,0.07337583,0.052489344,-0.04024678,0.046498,0.053213153,0.061067924,0.0072417706,0.019965693,0.09535393,-0.05375863,-0.039347254,-0.14910032,0.04549697,0.025133386,-0.04861468,0.05601928,0.03142081,0.040414028,-0.022201456,0.08313488,0.039991308,0.08556816,-0.03670858,-0.03942533,0.019754738,-0.067337856,-0.042215288,-0.08345092,0.034514263,-0.05475865,0.023795288,-0.038312297,0.0022579299,0.020329904,0.0132603925,0.033267908,-0.027606389,0.025865147,0.033946294,0.07595179,-0.031922977,0.02493941,-0.06849557,-0.11347712,-0.00413233,0.034043845,0.015072835,0.03653927,-0.0055942764,0.019348746,-0.022015503,0.12053336,-0.03565607 +1.14.21.11,"The enzyme, characterized from the plants Sinopodophyllum hexandrum and Podophyllum peltatum, catalyses the formation of a methylenedioxy-bridge. It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.",384,1.0,-0.019130293,0.026764538,-0.05007085,0.015017171,0.010795357,0.10598334,-0.040694952,0.0129007315,0.06096096,0.023698254,0.03789965,-0.058318865,-0.044085223,-0.026024332,-0.09067419,0.12512459,-0.10859557,0.031282015,-0.0062907394,0.052058823,0.014528594,0.01737836,-0.0018831283,0.02013011,0.010785476,-0.0099391425,-0.05238498,0.025171593,0.019069426,-0.06432509,-0.056630366,0.112001546,0.014963507,-0.0201387,0.069213025,0.08558663,-0.006996685,-0.052789394,0.008003043,-0.025097283,0.052596632,-0.06815542,-0.02621038,-0.014854008,-0.04803257,-0.044402964,-0.010218643,-0.028240211,0.00032773343,-0.0062537803,-0.010922355,-0.072905585,-0.029569862,0.012608305,0.014339411,-0.018014042,0.028348872,0.06271471,0.025717385,0.009009663,0.074074775,0.008692113,-0.026396345,0.06557565,-0.030412257,-0.07330486,-0.01078384,-0.007917001,-0.015756024,0.0006788493,-0.007941426,-0.06882147,0.02287379,0.022934278,0.02380492,0.00081339624,-0.018600399,0.01202,0.010146228,0.02226161,0.033053756,0.10373246,0.019352846,0.1417712,0.022143573,0.027536718,0.011133402,0.033998635,0.028212091,-0.04432618,0.019263545,0.022865204,-0.06435956,-0.02051081,-0.042903654,0.06830111,0.030818796,-0.031623445,0.018471207,-0.0011601971,0.05242354,0.056488264,-0.1042534,-0.1363059,0.047407035,0.0017819786,-0.039135773,0.0574302,0.0013820572,-0.010057425,-0.016616838,-0.054755043,-0.015007355,0.015865318,-0.06787706,0.074567445,0.04855122,-0.056481138,-0.023938203,-0.004809123,-0.0103411395,-0.039804906,-0.00029948598,0.06467808,-0.09662021,-0.011381186,-0.085581645,2.400521e-33,0.095039174,0.033057563,-0.01784531,-0.062178005,0.07954863,-0.021890055,-0.045063566,-0.04935936,-0.085835226,-0.038692188,-0.14874914,-0.028079575,-0.009919394,0.01868467,0.014515827,-0.018980399,-0.098838866,0.0056019444,0.03745704,-0.060386386,0.04901429,-0.007207742,-0.09341634,-0.005464085,-0.05401878,0.09930183,0.068421684,-0.05611008,0.03874275,-0.024383597,0.00011135898,-0.07723325,-0.06489241,0.0007491986,-0.036561616,0.020357605,-0.059616495,-0.033347767,-0.04566772,0.094638,-0.02526765,0.0027972092,0.02232102,-0.05751688,0.07346566,-0.059023503,-0.088584155,0.033937514,0.06604477,0.07796588,0.013501724,0.009812369,0.046035223,0.026198192,-0.08745576,0.035113283,-0.05575684,0.0014207578,-0.07886791,0.022495868,-0.031494964,-0.0554079,-0.014827571,0.037614334,0.017943345,0.043820817,-0.033125293,-0.05002856,-0.012473142,0.006585683,-0.08343155,-0.061035056,0.04452702,0.06115842,0.023004169,-0.011789349,-0.03625521,0.039861336,0.019366967,0.056769013,-0.03140309,0.0040895087,0.012791883,0.022389749,-0.036583398,-0.06725025,-0.01465432,-0.034893066,-0.03905165,0.043457784,-0.0017099405,-0.0696522,-0.08223463,0.017777875,-0.02716388,-4.7046043e-33,0.071139865,-0.030356457,0.06758135,-0.11247227,-0.025709217,0.054921262,-0.04925815,-0.009573619,0.02764029,0.06347242,0.048725765,0.043665394,0.0666258,0.0007176913,-0.008927149,-0.005221756,0.056433387,0.036374476,-0.051801648,0.029383527,-0.053253423,0.043306146,-0.059395634,0.06273285,0.02513793,-0.0017295845,0.07560123,-0.013036784,0.01910139,0.04853504,0.0025424256,-0.001663076,-0.08100191,0.05943714,0.0378005,0.04475032,-0.06196068,0.008834905,0.047429282,0.027146347,0.032173704,-0.032930966,0.023033185,0.008018048,0.08209248,0.016743243,-0.117907874,0.02994573,-0.00088377285,0.0011929307,-0.0012942688,0.100741,0.011158337,0.03876824,0.026281951,-0.00076788606,-0.01900214,-0.0076603023,-0.03965128,-0.021314472,0.005861088,-0.025114713,0.013723625,0.045109633,-0.023788812,0.109570615,-0.061433643,-0.021233357,-0.031906515,-0.009749949,0.06435735,0.056996565,0.0022763168,0.07349927,-0.028484223,-0.07294327,-0.0029535322,-0.06724298,-0.012623328,-0.022283096,0.062484886,0.043987345,0.066886455,-0.08109911,-0.035482556,-0.058844194,0.040375225,0.10881259,0.011433656,-0.00051550847,0.046917096,0.022313364,-0.13228272,0.034106217,0.06771695,-4.0785814e-08,0.02382395,-0.040421568,0.010923774,-0.08117716,-0.079009145,0.02613337,0.040733073,0.020957813,0.031733178,-0.05731078,-0.0006122496,0.056406926,-0.031836804,0.016539102,0.0067616077,0.0067237527,0.015933564,0.01726523,-0.021039926,-0.0072839693,-0.09590788,0.0006276128,-0.035314105,0.03183815,-0.024628615,-0.04141683,0.0027634301,0.004344146,0.02923613,-0.03295598,0.03795259,0.087664135,-0.06784291,0.0136793,-0.097500175,0.12531419,0.040708613,-0.07334453,-0.015952554,0.019230753,0.005029092,-0.009279143,-0.026087308,-0.03368198,0.033194043,-0.0030644361,0.021852188,0.041265953,0.048588406,0.066676795,0.052907012,0.013094283,0.021317394,-0.13660763,-0.14122035,0.050723046,-0.014132293,-0.02949586,-0.03499337,-0.04860891,-0.039879665,-0.025426444,0.2461122,-0.015216982 +1.17.7.4,"An iron-sulfur protein that contains an unusual [4Fe-4S] cluster [5,6]. This enzyme forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of 3-methylbut-3-en-1-yl diphosphate and prenyl diphosphate.",384,1.0,-0.052778117,-0.01881898,-0.07608213,0.016107308,0.077834204,0.009415043,-0.031157475,0.047842093,0.05881416,-0.039950795,0.025131028,-0.01494242,-0.037740804,0.012916551,-0.10358607,0.057913266,-0.030093685,0.029874709,0.008088288,-0.024348773,0.064373754,0.022690432,-0.023114556,-0.08113192,0.034021422,0.028328229,0.043477174,0.012628365,-0.023664942,-0.055619173,-0.037865795,-0.00085433543,0.0527999,-0.09070726,0.01960054,0.15743785,0.008511153,-0.08324054,0.025549678,-0.013621315,-0.0019270111,0.0068980055,-0.0240899,0.002329066,-0.059412956,-0.013499606,-0.03594898,0.0352268,0.031908307,-0.06589741,-0.08430557,-0.020463517,-0.04962026,0.041025843,0.055767205,-0.028259065,0.01089054,0.0011885436,0.0018331049,-0.042198144,0.06869657,-0.043900322,0.019024638,-0.020639986,0.044435643,0.021841383,-0.008538662,-0.02693594,0.024695838,-0.0758031,-0.059177794,-0.0060866317,-0.06742396,0.057292845,-0.03164177,0.05779698,0.026444191,-0.025399582,0.046428103,-0.0012970673,-0.0012508554,0.05959522,0.052427616,0.052124687,0.05544516,-0.029081305,-0.037602674,0.007179212,-0.00042806528,0.05542736,-0.029573062,-0.01752946,-0.04944397,-0.0076747737,-0.024244871,0.06326926,0.026612027,0.014339972,0.025267683,-0.02884753,-0.026473839,0.039538532,-0.028663151,-0.073482014,-0.028571341,-0.036676303,-0.05497754,0.09038028,0.002289365,-0.005085484,-0.0058751525,-0.012833485,0.04132015,-0.020523602,0.031935774,0.08632098,0.055500504,-0.024670988,-0.09998674,-0.0018176005,-0.004766969,0.01104465,0.025618805,0.1006647,-0.019227607,-0.013148241,-0.18394026,-7.015394e-34,0.065348186,0.047902096,0.010371305,0.022253854,-0.007139189,-0.04161186,-0.040102147,0.013227197,-0.014458763,-0.00074908196,-0.07596706,-0.10275372,0.04136476,-0.08203475,-0.04282729,-0.0626264,-0.030488707,0.0068501146,0.06453148,-0.0029602346,0.017298335,0.066238075,-0.019629292,-0.053495284,0.011530693,0.07652587,-0.046924945,-0.02924943,0.019875174,-0.012750177,0.012704661,-0.089394525,-0.09052748,-0.0101300515,0.082591005,-0.018425124,-0.028260132,-0.015873916,-0.06716195,0.023815924,-0.032677047,0.03941999,-0.021403844,-0.08142793,0.13239808,-0.08375226,-0.07864238,0.066893466,0.061380953,0.07000114,0.028344091,-5.9711452e-05,0.11926922,-0.029351367,-0.12534435,-0.016091624,-0.02123295,0.0013596809,0.013673925,0.09918914,0.045245025,0.06296951,-0.05769634,0.060783178,0.02517667,0.021855496,-0.05718056,-0.051057186,0.05720058,0.15078235,-0.004766218,-0.06016837,0.04693386,-0.008357952,0.025658933,-0.06583887,-0.04346698,0.031137083,0.06720991,0.0058048815,-0.0067089656,-0.0024256215,-0.032467164,-0.06785851,-0.03436082,0.03130702,-0.01959274,-0.042763826,0.01718725,0.035594396,0.069211364,-0.062163323,-0.054903205,0.008230061,-0.030207109,-7.7938885e-34,0.06877063,-0.06940748,0.04862056,-0.045488145,-0.04679416,0.079505935,0.032911103,0.0025074445,0.0149934245,0.04169195,0.103680275,-0.013529377,0.01348786,-0.016606612,0.016953196,0.07354292,0.016287547,0.069845594,0.00094357075,0.013791663,-0.023412663,0.1139432,0.0012543388,0.062182423,-0.0047725528,0.01477612,0.022892749,-0.003391993,0.028987672,0.047511518,-0.019966714,0.03446576,-0.05969198,-0.060661666,-0.029174095,0.015986083,-0.1309022,0.021315098,0.039603718,0.03917816,-0.007143179,0.03947672,0.010630433,0.07755956,-0.0268228,0.026699988,-0.10647509,0.06627823,0.014143666,-0.024144758,-0.004088453,-0.016403252,-0.04216051,0.032290023,-0.003420011,0.036959857,0.019926134,0.10983112,-0.0034452118,0.051807802,-0.06295477,-0.09938782,0.07320328,0.0055555734,0.11413487,0.101064056,-0.026065495,0.026001543,-0.015334372,-0.0015868943,0.046641063,-0.00094967574,0.011705533,-0.04093197,-0.025780346,-0.06413652,-0.049620673,0.036038835,-0.020109445,0.00873431,-0.04184658,0.01703948,-0.010197217,-0.05146118,-0.022039156,-0.14850406,0.011971713,0.09448364,0.053722583,0.04432494,-0.018165302,0.02237271,-0.039078422,-0.027551303,0.07344529,-4.5481457e-08,-0.038337674,-0.04815404,0.06299068,0.016382214,0.023510415,-0.02259089,-0.0024229821,-0.009028015,0.048575796,0.055903077,0.0022111363,0.10755505,-0.004031928,-0.06478151,0.02892897,0.008762889,-0.040489793,0.020741824,-0.0056510814,-0.005932153,-0.04212596,-0.028939541,-0.10224615,0.04203759,0.09706545,-0.107338764,-0.008004854,-0.0024966118,0.07032522,-0.030067915,0.030623654,0.032987818,-0.009569627,-0.048922516,-0.135475,0.033532243,-0.07000915,-0.02374793,-0.059624694,0.029859798,-0.039993536,-0.03802408,-0.029627472,0.026594572,-0.04643631,0.06770094,-0.013176241,0.04365443,-0.022102293,0.008276393,0.016895914,-0.022751018,0.042665437,-0.08590307,-0.07172746,0.07428689,0.054492157,-0.01771399,0.05582577,-0.0015638137,0.019599257,0.008296469,0.15189561,-0.04997517 +1.21.98.2,"This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. In vivo the enzyme uses hydrogen peroxide, formed by the enzyme upstream in the biosynthetic pathway (EC 1.4.3.23, 7-chloro-L-tryptophan oxidase) as the electron acceptor. However, the enzyme is also able to catalyse the reaction using molecular oxygen [3].",384,0.99999994,-0.04225606,-0.007349816,-0.1363629,-0.025675645,0.03998382,0.0366542,-0.04969512,0.071042165,0.08663319,0.031960994,-0.037626874,-0.030238139,0.0039523086,-0.020355796,-0.062281974,0.11963763,-0.043803796,0.051896468,-0.05107887,-0.010489621,0.032640763,-0.010285229,0.034118697,0.0017849382,0.044381123,0.027781887,0.05554748,0.08092282,-0.10851765,-0.06453603,0.02372972,-0.06435971,0.041239884,-0.032025766,0.04613242,0.039474394,-0.030012012,-0.030743502,0.06350895,-0.0064930776,-0.034733504,-0.023179654,-0.06235535,-0.0016785376,-0.06438416,-0.031009046,0.04821357,0.025685633,0.03539046,-0.04165738,-0.042870104,-0.047236893,-0.048310533,0.010571029,0.02945935,-0.022056127,-0.029135786,-0.0248002,0.025119001,-0.016825434,0.045544934,-0.029752765,-0.021090703,-0.0070078485,-0.06363421,-0.11473648,0.0022003138,-0.07760947,0.013773102,-0.062707804,-0.05634897,-0.046932373,0.01842358,0.036723297,-0.006150751,0.02444859,0.01928126,-0.036530096,-0.0056847897,-0.014715865,0.008564612,0.032534357,0.06355893,0.15453282,0.0294865,0.07625107,0.034845416,0.017368885,0.010117018,-0.010670225,-0.017127078,0.0294279,-0.03438254,-0.07215573,-0.05173681,0.0034199993,0.0030307705,0.08778851,0.017236698,0.007110609,0.016328745,0.030922752,-0.05404302,-0.10806936,-0.021691633,0.0020701133,0.011207901,0.13757582,0.08817814,-0.05942577,0.0026771629,-0.03392736,0.010233006,0.029078456,-0.034396525,0.10040802,0.08356416,-0.061060484,-0.09570503,0.045374066,0.061417915,0.0275074,0.051454913,-0.017174752,-0.03922951,0.02676656,-0.068382904,4.948845e-33,0.052707322,0.12855652,-0.013281339,0.010812198,-0.047513496,-0.016466506,-0.1296211,0.011044981,-0.012442702,0.00026983235,-0.08911981,-0.088150516,0.036846247,-0.044019017,-0.036262818,-0.0077837207,-0.07122503,-0.0074932543,0.00054372655,0.055576064,0.030835317,0.023902023,-0.03961158,-0.00016463494,-0.0058911177,0.05206481,0.021136772,-0.008557295,0.08121058,0.005425916,-0.009650341,-0.031975936,-0.0969481,-0.056691494,0.023348281,-0.02117146,-0.049070682,0.03803036,-0.0009539716,0.072429955,-0.0038264885,0.037063193,-0.0072196587,0.00083346356,0.0623789,-0.060408685,-0.021026239,0.12754926,0.11886321,0.070431255,0.004697315,-0.029754076,0.1492027,0.018208232,-0.08458663,0.025842939,-0.01960606,-0.00058167597,0.07708019,0.04840426,0.0014200076,0.036934916,-0.016330019,0.0037390424,0.064861506,-0.024686862,-0.01855422,-0.06148435,0.0002452092,0.075257294,-0.038333412,0.020076774,0.10046008,0.02625352,0.0034286676,-0.037702475,0.0073080915,0.010366304,0.086537376,-0.0064910064,0.05549052,-0.041262157,0.017312564,-0.09644976,-0.029097518,-0.02253898,-0.07773107,-0.04597716,-0.08803481,0.029822957,0.04890711,-0.10833136,-0.08535758,-0.057355475,0.00039004185,-5.2457346e-33,0.10045256,-0.06815276,0.01914025,-0.07148375,0.027292525,0.03229565,-0.022595027,-0.02933249,-0.01565074,-0.01699624,0.108123265,-0.058689218,0.033744503,0.018168535,0.034614958,-0.036560655,-0.043282,0.08996625,0.0078016184,-0.0112635605,-0.021477181,0.064541854,-0.031231241,0.012263138,0.07466746,0.035640858,-0.03723678,0.024101442,0.061637353,0.06506948,0.030233944,-0.019271499,-0.07758316,-0.02951133,0.014166135,0.07209889,-0.08696208,0.030571291,0.09230647,0.023404915,-0.0019046823,-0.036065117,0.0020097073,0.012908045,0.05995028,0.037842605,-0.11102879,0.064458735,0.01688274,-0.06303366,0.009886179,0.024607474,-0.07371533,-0.022968702,0.050254483,0.045135435,0.04767138,-0.019362392,-0.013320091,-0.021925306,-0.08427722,-0.03695333,0.10638168,0.016981734,-0.044707377,0.11645093,-0.006658079,0.072846524,0.049444437,0.0036612435,0.009368875,0.010290801,0.014069157,-0.018674245,-0.0055750585,-0.015385424,-0.015855962,-0.029131802,-0.020441584,0.039501578,-0.020682752,0.018631175,0.027695676,-0.056725875,0.015922762,-0.04866509,0.015985616,0.06837665,-0.030624475,-0.04308191,0.029683307,0.008261352,0.02906185,0.06342766,0.019382777,-4.938679e-08,0.047459736,-0.07016139,0.06456092,-0.043951068,-0.0043227538,0.031262577,-0.008854829,-0.038718168,0.049274858,-0.021568371,0.012405926,0.1025694,-0.03146211,-0.026314095,0.010723055,0.0049693286,-0.013838214,0.04649646,-0.008674734,-0.015060779,-0.044878468,-0.036706146,-0.06219185,0.025237318,0.043526344,-0.06399696,-0.021322496,-0.017008564,0.025187837,-0.027396416,0.035563584,0.057636395,-0.049501866,-0.004197396,-0.057757605,-0.035579912,-0.06713845,0.045359265,-0.054416202,-0.04465044,0.073898174,-0.05303755,-0.11204772,0.024535386,-0.014693695,-0.0041954448,-0.0065726885,-0.01457533,-0.06274525,-0.03120634,0.031363398,0.021752939,0.015017806,-0.024351032,-0.14009795,0.07777573,0.0061380174,-0.055828646,-0.0023973947,-0.08468397,-0.045304693,-0.00034115018,0.14601244,-0.025359169 +2.1.1.323,"The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.",384,0.99999994,-0.012249111,0.01880922,-0.07119016,0.023771247,0.027877402,0.12931362,-0.054166507,-0.0009702234,0.061735444,0.017887011,0.020085426,-0.04247516,-0.06040135,-0.008990172,-0.085900486,0.06371079,-0.07674411,0.0138120465,-0.021185378,0.0021042088,0.0017608954,0.05315498,0.03172924,0.030318005,0.037503116,-0.054987438,-0.085525475,-0.0011884307,0.012902997,-0.0507211,-0.006631137,0.071572386,0.022127755,-0.026982054,0.06903,0.07708543,-0.030878328,-0.0370162,-0.0090312855,0.031912424,0.0463251,-0.049360003,-0.08033283,0.019761853,-0.038021635,-0.045164637,-0.055667143,-0.07253206,0.033229038,0.046084348,-0.04876543,-0.078831755,-0.045605373,-0.006914129,0.02726238,-0.041466467,0.053454634,0.061640102,0.03157652,-0.012601081,0.08997956,0.008375367,0.013180162,0.070643514,-0.01715647,-0.064652815,-0.02562768,-0.03444281,0.008963257,-0.027979871,0.0130340895,-0.09836179,0.061914645,0.03881283,-0.02134274,-0.00242275,-0.011670904,0.015726946,-0.03219273,0.0063516023,0.099909,0.09065731,0.06713458,0.14578104,-0.0069557643,0.030898038,0.019628821,0.010817922,0.00068428443,-0.04509085,0.03212795,-0.022802636,-0.040833246,-0.0217566,-0.039121505,0.045692734,0.05024829,-0.050026506,-0.010671624,-0.039546542,0.047846694,0.012800969,-0.1250543,-0.13031897,0.041378975,0.0034366979,-0.079077646,-0.016828122,0.012443926,-0.009249429,0.0059083086,-0.033453587,-0.037471306,0.026949529,-0.013387649,0.07175277,0.035376985,-0.040105335,-0.028380793,0.039615292,-0.016332377,-0.05376644,0.03885991,0.07521126,-0.056934144,-0.021989482,-0.07509597,1.9573006e-33,0.09006086,0.043843422,-0.025854085,-0.059053045,0.07143854,-0.08922413,-0.048955444,-0.07532324,-0.08563709,-0.006564477,-0.10995776,-0.009368,-0.009144643,0.020955013,0.01108631,0.0033396338,-0.07599434,-0.011700088,0.044502974,-0.057016604,0.040484976,-0.02489291,-0.110298604,0.019974694,0.003419746,0.117600754,0.037443545,-0.020049557,0.04086802,-0.037978932,-0.0035484843,-0.058957774,-0.066035084,0.019043958,0.006147443,-0.024433551,-0.028395299,-0.040652104,-0.05468062,0.052214537,0.010638251,0.007708873,0.01634299,-0.05612555,0.09610017,-0.003513858,-0.084693186,0.018882234,0.059025656,0.03997099,0.02045618,-0.009850082,0.10217663,0.025597328,-0.061177775,0.026207803,-0.036285024,-0.013943276,-0.016516207,0.034134626,-0.011696132,-0.06074652,-0.027445352,0.02950248,0.036837697,0.05204816,-0.041226007,-0.07967854,-0.0068608243,0.0131582115,-0.09229252,-0.04572663,0.055935256,0.06503427,0.038498253,-0.0065454305,-0.034934144,0.05229265,-0.052200437,0.04262001,0.0170564,-0.029122856,-0.009261484,0.0147187,-0.042269483,-0.060610447,0.0056767124,0.025887715,-0.037850108,0.0153828375,0.010869665,-0.0530672,-0.058055945,0.019533344,-0.048452254,-4.2920946e-33,0.067661494,-0.04968999,0.08033887,-0.06737974,-0.016224109,0.09184972,-0.04695682,0.009151135,0.0792131,0.073886305,0.042202894,-0.008001409,0.08192674,0.023701958,-0.044605855,0.005456463,0.014403848,0.029429628,-0.061364587,0.008631591,-0.087623976,0.00082806294,-0.054054014,0.030780243,0.02748506,0.014213452,0.035687763,-0.012541029,-0.0268624,0.04654965,-0.0015216921,0.02724478,-0.09154635,0.04727973,-0.001479641,0.020840483,-0.08313125,-0.004795183,0.029045599,0.021322966,0.041026562,-0.01353703,0.022636693,0.02396467,0.08897527,0.018666264,-0.11146662,0.060902413,0.014271131,-0.0315165,-0.0045178086,0.080724105,0.0077119553,0.05908204,0.026895242,0.035191517,-0.011339945,-0.025310114,0.00016145465,-0.0206711,0.029839639,-0.026574427,0.027786754,0.07042338,-0.026300082,0.12057636,-0.041372053,0.0003727645,-0.0054822573,-0.011589341,0.07271902,0.023240583,0.054112583,0.0853632,-0.046583276,-0.034894742,-0.01169614,-0.08297717,0.014487199,0.013899434,0.04863538,0.043574933,0.03167379,-0.05844402,-0.009294486,-0.024508515,0.04389789,0.1233464,0.010844447,-0.0371112,0.04905957,0.009161161,-0.11497433,-0.008890936,0.07502227,-3.6363872e-08,0.059484832,-0.012626253,0.049555864,-0.07454959,-0.0322124,-0.022186968,0.049949538,0.013771678,0.04984482,-0.03392771,-0.030072639,0.048265345,-0.052067664,-0.0032182427,0.008153792,0.01744252,0.02600493,0.05962604,0.0034069712,0.00371808,-0.06140346,-0.008268734,-0.044701945,0.005035617,-0.014546647,-0.041626927,0.024763964,0.022779021,0.02993644,-0.05247111,0.0037514854,0.059365157,-0.060556732,-0.028776627,-0.12725462,0.07965996,0.05210197,-0.08563418,0.0019398318,0.0054714954,0.0027683247,-0.035036664,-0.030937472,-0.044138264,-0.04185692,-0.0010361533,0.07887737,-0.01692615,0.026678624,0.056616206,0.016681172,-0.01560585,-0.0063571944,-0.12692262,-0.11338566,0.031910345,0.007123309,-0.035838667,-0.045134343,-0.06675742,-0.056339897,-0.07383747,0.27053073,-0.0045948457 +2.1.1.324,"The enzyme was isolated from the bacterium Saccharopolyspora spinosa, where it is involved in the biosynthesis of spinosyn A, an active ingredient of several commercial insecticides.",384,1.0,-0.063985355,-0.008264903,-0.16631308,-0.057010222,0.04778837,0.05122734,-0.0668658,0.009929135,0.029396389,0.05339534,0.05079712,0.0403917,-0.020777274,-0.0027463576,-0.07156057,0.10550692,-0.04807824,0.007251566,0.0028208236,-0.042826027,0.04810244,0.030234616,0.019170303,0.030611815,0.005636561,-0.030781053,0.059801195,-0.022812314,-0.043107074,-0.07682119,0.031353723,0.07203606,0.0009617232,-0.1335586,0.07162095,0.0858517,-0.012350369,-0.039886005,0.06910245,-0.030417988,0.076538324,0.04173745,-0.018729037,-0.03959327,-0.094233364,0.030925691,0.04018892,0.06711528,0.07461696,-0.052444547,0.0014427535,-0.04948605,-0.03153331,-0.06287416,-0.0145664355,-0.04200749,0.06639881,0.021624953,-0.057373356,0.021420864,0.061245542,0.018030515,0.0068790154,0.038598258,0.005819313,-0.045564912,0.003984568,-0.055904005,0.04174101,-0.096003436,-0.061932873,-0.106867954,0.024127865,0.07246448,-0.022747183,-0.0076612667,0.029017847,-0.03614377,0.05830924,-0.024432648,-0.011520366,-0.08712947,0.032653395,0.087995715,0.033759538,-0.014138297,0.038853828,0.041337974,0.10263372,0.06123237,0.015405081,-0.019133454,-0.023578232,-0.072897255,0.01579116,0.011411549,-0.03500838,0.0074913953,-0.04212822,-0.008451075,-0.021404712,-0.029776342,-0.0082818875,-0.13013174,-0.111317486,0.016665284,0.0225183,-0.039919376,0.015681727,0.044165324,-0.02477392,0.06756055,0.009499911,-0.005277276,-0.07837882,0.0048795906,0.082274646,-0.073741294,-0.008437641,0.02983402,0.01456139,0.010302081,0.03326368,0.022739438,0.011873224,0.04533341,-0.13130637,-9.103803e-34,0.062300004,0.022692677,0.014617555,-0.06034575,0.026699005,-0.015564128,-0.009237712,-0.05008133,-0.021189801,-0.03488551,-0.06455809,-0.1645886,0.031584594,-0.0519171,-0.028612686,-0.000846556,0.085909545,0.0016536207,0.048131876,-0.038350876,-0.030426089,0.06902972,-0.105689935,-0.00040059767,0.030142972,0.050790977,-0.044576183,-0.04954971,0.008200273,0.0088082915,0.09611554,-0.020879924,-0.118751675,0.069543965,0.12750675,-0.025505414,-0.031272165,-0.08054745,0.012787189,0.035902258,0.0454092,0.01743228,0.0715265,-0.017011095,0.006446113,-0.02310699,-0.076549634,0.039388075,0.13428225,0.06218038,0.006748772,-0.032581355,0.0801556,-0.055626545,-0.07555788,0.009950162,-0.014947472,-0.03321624,0.041127913,0.055455647,-0.039647907,0.08716509,-0.0654536,-0.055585384,0.07175668,-0.030610288,-0.04878161,-0.06597304,-0.0932628,0.008735105,-0.04383445,-0.07707018,-0.0010237223,0.005784342,0.007794164,-0.0077964184,0.0008289873,0.01586848,-0.020075941,-0.018530393,0.05058534,-0.05362375,0.011952725,-0.040822938,-0.0710355,0.07702277,-0.047718313,-0.024779256,0.00021947142,0.028299361,0.013996356,-0.024868751,-0.01624211,-0.003127102,-0.015432338,-2.6351926e-33,-0.009352766,-0.024616523,0.067020185,-0.09743989,0.012310844,0.09119253,-0.014265327,-0.026416332,-0.04942403,0.02345336,0.011935425,-0.031356424,0.027489172,-0.024686966,-0.026290812,0.07198516,0.07403689,0.04884926,0.04923377,-0.00088742335,-0.017821115,0.10423703,0.025579663,-0.039210342,0.010464823,-0.078904554,0.042401828,0.107439734,0.06148898,0.05034784,-0.030294241,0.011156027,-0.020400126,-0.012574462,-0.05849344,0.010610395,-0.041534454,-0.0870347,0.021198735,0.018362805,-0.014266868,0.023131086,0.009103767,0.029500997,0.041969243,-0.016001208,-0.094182715,0.07244622,0.0030902324,-0.010915009,-0.0016988629,0.05384738,0.101525635,-9.152902e-05,-0.012773771,0.032827407,0.035123747,0.020960368,-0.001595025,-0.06743654,-0.016196162,-0.03239767,-0.06253367,0.030590266,0.049901858,0.109576255,-0.026465798,-0.007931126,-0.002408688,-0.06948839,0.013967549,0.059928127,-0.0058231456,0.002306941,-0.04617935,-0.009341014,-0.054754876,-0.07402039,0.019696344,-0.014323661,0.029269177,0.047000695,0.033685286,-0.0873065,0.038192,-0.050341073,0.0026014335,0.025839947,0.029934362,-0.008110847,-0.018190775,-0.0070034065,-0.04327638,0.105812386,0.04746168,-3.0728938e-08,-0.0028201365,-0.031662382,0.02922637,-0.031210644,0.02405901,-0.015881253,0.031627793,-0.056139413,0.05335805,0.03271435,-0.04782834,0.068191424,0.02296314,0.009039711,0.09753121,0.013628756,-0.03625071,0.037905186,-0.021451268,0.055057485,0.018931404,0.0061203986,-0.13822016,0.0071635353,0.009212108,0.023529388,0.041898116,-0.022337765,-0.011475786,0.01227518,0.00010258139,0.042343456,-0.011240574,-0.076980196,-0.14454024,0.0029438485,-0.054133013,-0.012786442,0.002726744,0.055423528,-0.010523258,0.027933251,0.012011804,0.049101513,-0.032628544,-0.013532554,0.010524621,-0.016549833,-0.02574935,-0.002880585,0.09898522,0.03814452,0.008827144,-0.03170544,-0.05215392,-0.026469696,0.010920691,-0.11654031,-0.0132635385,-0.0058630197,0.004477578,-0.017175782,0.15732098,0.004689562 +2.6.1.110,"A pyridoxal-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine.",384,0.99999994,-0.06612151,-0.048659205,-0.13212515,-0.06496187,0.035592876,0.025428096,-0.0043123104,-0.004111152,0.043956514,0.086537704,0.011268025,-0.016559869,-0.021543793,0.04236528,-0.057140823,0.06476538,-0.06118335,-0.009760446,0.07724462,-0.0381209,0.1199454,0.011003821,0.025042923,0.017894095,-0.012414556,0.06612054,0.059033617,-0.016348809,-0.04341418,-0.055139504,-0.0579427,-0.0020555046,0.035065264,-0.12979826,0.060973845,0.14838538,-0.044965677,0.00034038248,0.0132576795,-0.033019047,0.07944316,0.0006804218,-0.005686783,-0.0046127634,-0.081517056,0.04003337,0.086425,0.055433434,0.0709677,-0.066121824,-0.0428502,-0.019222576,-0.04028789,-0.0018987632,-0.0065203863,0.031259555,0.039844565,0.031499397,-0.058604475,-0.02651154,0.018692529,-0.0086542275,-0.0026924752,0.011477998,0.016296417,-0.070924394,0.011392254,-0.045067344,-0.038940396,-0.027846482,-0.06264512,-0.042252384,0.1248915,0.07994559,-0.044378404,0.036979396,0.033992328,0.0032202136,-0.0034025542,0.006170661,0.039660037,-0.010879161,-0.0056808977,0.095379494,0.053992536,-0.025519788,0.04472441,0.004836871,0.073043,0.014119777,-0.027859021,0.0029566668,0.014979484,-0.021850007,-0.069568135,0.00010582207,0.016493374,-0.0036059646,0.016819492,-0.053307652,0.019538043,-0.038603317,0.024689011,-0.11247578,-0.08073904,0.009938792,-0.06216006,0.033142112,0.06280698,0.053303666,-0.010754428,0.087171175,0.021866534,0.027374433,-0.04310154,0.03643116,0.03246325,-0.08491563,-0.062031075,0.04568413,-0.007508164,-0.0073863757,0.017159468,0.12400604,-0.06478236,-0.038564134,-0.14952119,7.165079e-35,0.0756543,0.04150259,0.031069089,-0.024445461,-0.0038182016,-0.0018516307,-0.012554599,-0.055944517,-0.054181743,-0.05444138,-0.04143919,-0.08853468,0.06994856,-0.0034435818,-0.060082655,-0.017402986,-0.018215697,0.03698053,0.08203644,-0.028201055,-0.027126215,0.10206284,-0.087794684,0.021249384,0.031182585,0.07649349,-0.046863947,-0.057885587,-0.018339852,-0.005249198,0.081426516,-0.09324707,-0.1322992,0.00472761,0.085273154,-0.07467887,-0.02950101,-0.06085284,-0.032978848,0.012805882,-0.009955393,-0.011644514,0.0119005535,0.027745165,0.007390968,-0.06382274,-0.009402543,0.026147708,0.036065042,0.09172083,0.02311591,-0.08486972,0.07476903,-0.03401956,-0.16394159,0.02083229,-0.019663734,-0.044812355,0.028381193,0.04574513,0.026608605,0.01654094,-0.06771688,-0.006820911,-0.018541867,-0.06514813,0.009642269,-0.069517255,0.019294681,0.063982785,-0.06725687,-0.029666072,0.026448237,0.020085638,-0.027202185,0.0066710385,-0.040328518,0.021594496,-0.031034624,0.060277928,0.0033423994,-0.08852697,-0.036619604,-0.05525062,-0.06713578,0.04060248,0.020812325,-0.062020596,-0.041593693,0.0018251039,0.050956897,-0.09287722,-0.045605734,0.012492315,-0.030358361,-2.5784173e-33,0.08423853,-0.08883453,0.10609507,-0.060204145,-0.016803525,0.019872606,0.07449012,-0.011709225,-0.05661623,-0.040548585,0.014136025,-0.069268785,0.026533734,0.008177215,0.0048030606,0.054869484,0.0021595405,0.042518627,0.05351024,0.024676822,0.007139788,0.08889462,-0.007609859,-0.0013306679,-0.020803006,0.0079183355,0.014529655,0.053934727,-0.009989444,0.054925602,-0.026234003,0.04745029,-0.054745886,-0.053431273,-0.06218683,-0.032731295,-0.07908877,-0.062125996,0.0229727,0.019713912,0.04157362,0.074227765,0.02105662,0.0059218644,-0.01595507,-0.0021369134,-0.02627751,0.036822353,0.0064189425,-0.01685473,0.035686772,0.033500444,0.047330685,-0.034457847,0.010829374,-0.024023622,-0.057045978,0.042424716,-0.0021353515,-0.0135786235,-0.024165345,-0.07407351,0.019487059,0.08975424,0.036079176,0.14030088,0.009121877,-0.02795937,0.028181063,0.03807776,0.025666654,0.02301857,0.012845646,0.06784921,-0.042646177,-0.007953592,-0.090039894,0.010447248,0.02263251,0.020763518,0.009477786,0.021496434,0.021928117,-0.074384496,0.02182293,-0.010851708,0.07960943,0.069822714,0.010674145,0.015925286,0.005743683,0.0008294825,0.007797681,0.09687257,0.08816083,-3.1772768e-08,0.017609,-0.04397389,0.011522909,-0.022360168,-0.0058393474,0.022450937,0.04701036,-0.054064758,0.08356887,-0.0025262435,0.013908137,0.03181236,0.0327708,0.019474154,0.09536918,0.064634666,-0.048041746,-0.0075208438,-0.0075754626,-0.003005547,-0.025770832,0.0024546706,-0.15300673,0.07245404,0.09068211,0.024896897,-0.007740463,0.015602419,-0.012049423,-0.032340366,-0.001894617,0.0192738,-0.02163236,-0.05380854,-0.037427016,0.04156662,-0.048797887,-0.03419878,-0.017576182,0.052781705,-0.016603403,0.009778716,0.019866718,0.0022058268,-0.021957288,0.078989655,-0.019008635,0.02069243,-0.027364854,-0.03826573,0.0348972,0.022004226,-0.083989725,-0.08721272,-0.12020719,0.019909205,-0.0066005695,-0.046478167,-0.045672905,-0.01977774,0.011906938,0.0077782776,0.14029117,-0.096788995 +2.7.1.191,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.192,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.193,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.194,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.195,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.196,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.197,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.198,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.199,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.200,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.201,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.202,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is usually a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). The enzyme from the bacterium Escherichia coli is an exception, since it is phosphorylated directly by EC 2.7.3.9. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,1.0,-0.043852013,-0.020524364,-0.081233405,-0.01018011,0.05940122,0.04264629,0.022446875,0.06539191,0.043661494,0.045532662,0.011164548,0.00077010377,-0.056757573,0.056745257,0.003301683,-0.023920782,-0.040406708,0.016387418,0.025166394,-0.0667937,0.12839356,0.0366841,-0.013921553,0.006094253,0.037467472,0.0014504808,0.069161475,-0.04103671,-0.033794284,-0.071976826,-0.061075993,-0.11446831,0.008944065,-0.031844944,0.04372774,0.14685732,-0.019144928,-0.10837087,0.030782973,-0.017888598,0.061848,0.025716009,-0.009309716,0.003586828,-0.01915629,0.022393726,0.034488644,0.04757056,0.013958873,-0.07151736,-0.052520815,-0.04699468,-0.011804155,0.0318103,-0.005478378,0.06965384,0.0013100933,-0.009778638,-0.017568998,-0.023019083,-0.029773666,0.019166833,0.08000079,0.028212484,0.030705906,-0.055671792,0.041584883,-0.08491366,-0.018204244,-0.064485215,-0.066215016,-0.03151228,0.06943663,0.030490097,0.06073845,-0.0139036905,-0.009067326,0.058099777,0.004530683,0.0070424518,0.07916432,-0.022436121,-0.028586788,0.014309783,-0.01582096,-0.032983236,0.02514154,0.025744507,0.00063016504,0.008455356,-0.020110812,-0.048510987,0.055369094,-0.03336524,-0.040876802,0.0026167838,-0.015970943,0.015648473,0.054893855,-0.024054445,0.0137342,0.11420488,0.028165655,-0.038359772,-0.015989812,0.03612159,-0.04220237,0.093060635,0.035248928,0.0144336205,0.029132357,0.050761797,0.057556756,-0.008118422,0.00847954,0.047307838,-0.019884046,-0.067827195,-0.019385263,0.041219365,0.03209735,-0.07954422,0.02598323,0.05165097,-0.09642458,0.08705274,-0.14688584,2.6415882e-33,0.005498077,0.013578976,0.01824358,-0.038964212,-0.0055001127,-0.00092977274,-0.07128941,-0.036208574,-0.051023655,-0.07496617,-0.09008328,-0.08862365,0.041811652,0.028092187,-0.023990676,-0.019266874,-0.048311792,0.07740827,0.10877535,0.035708956,-0.004492058,0.016748995,-0.017233485,0.018457692,0.04458686,0.10191225,-0.0672828,-0.01521804,0.030042803,0.0005056498,0.029072087,-0.05596421,-0.07366891,0.0034015432,0.0541436,-0.09228666,-0.023235308,-0.056521285,0.01636194,-0.0050542615,-0.01888505,-0.015107815,0.0014218796,0.009303205,0.051871244,-0.107452795,-0.030793754,0.03587122,0.036148503,0.05503071,0.022821845,-0.07438172,0.11377199,-0.046717774,-0.050844073,-0.021275587,0.0063619125,-0.017255187,0.061909728,0.04551876,0.019239822,0.093836024,-0.023854757,0.014953999,-0.008683874,0.021616023,-0.06766024,-0.07427188,-0.028218,0.11099491,-0.055732705,-0.01820995,0.044297036,0.023994936,0.037256967,-0.06644089,-0.0325007,-0.004619473,-0.009522355,0.019226559,0.019301942,-0.04364224,0.022712953,-0.031871308,-0.01679697,-0.033914242,-0.02044525,-0.06581288,-0.04298721,0.063750856,0.042776175,-0.06288922,-0.07444846,0.045703363,-0.011918611,-4.5451797e-33,0.13408042,-0.046824694,0.060228046,-0.11192349,-0.06283502,0.04007245,0.00777972,-0.029519865,0.040791847,-0.018232848,0.012102834,-0.025222125,0.0822851,-0.032537702,0.036886983,0.037925124,-0.0213908,0.08191629,-0.00036334226,-0.006567026,0.026304647,0.07456856,0.026367495,0.04631431,0.05588398,-0.04812687,-0.03585415,0.09878019,-0.011323571,0.012220288,-0.02901522,-0.03438931,-0.071287744,-0.042443316,-0.10282076,0.002076215,-0.08539871,-0.060569152,0.042080693,0.029803272,0.055049617,0.07286478,0.039140943,-0.027581874,-0.031349346,0.08691147,-0.018706637,0.039684862,-0.00760694,-0.03067848,-0.03484897,0.014135399,-0.028738108,0.030068003,0.018396998,0.06990429,-0.039581645,0.092172265,-0.02593818,-0.05072852,-0.01114629,-0.12650128,0.037969593,0.013964939,0.054778427,0.014870986,0.006032822,-0.014683023,-0.00086412224,0.02511541,0.033906505,0.027876325,-0.018874949,0.06048227,0.013943948,-0.011205846,-0.12199043,-0.015646985,0.025522212,-0.06781062,0.020868447,-0.017178508,0.0083156265,-0.09104431,0.055381175,-0.043855593,0.0508971,0.093392625,-0.0065137637,0.0041276678,-0.030145058,-0.01667038,-0.037211485,-0.016635127,0.05591337,-5.2110668e-08,0.036044795,-0.04754761,0.020019745,-0.070533514,0.024426794,0.01051641,0.015559045,-0.0075098607,0.03281571,-0.012627996,-0.030394075,0.058516406,0.010374469,-0.037739545,0.048511297,0.055821456,-0.062868185,0.04428826,0.0038390884,-0.011129415,-0.037126873,-0.05363467,-0.09828482,0.08019706,0.055701923,-0.009431562,0.08205218,0.043227773,-0.033431545,-0.05506692,-0.014864505,-0.014616342,-0.03583155,-0.035013076,-0.06941931,0.024339247,-0.032966245,-0.00066832284,-0.012224005,0.025413522,0.002942841,-0.027206268,-0.054626614,0.039268292,-0.025063744,0.13643628,-0.012118969,0.060169652,-0.074315675,-0.008806954,0.07011365,-0.06721405,-0.068082646,-0.07401983,-0.114832886,-0.02518901,-0.014062077,-0.055519436,0.02987957,-0.026022136,0.07825212,0.09762599,0.20239516,-0.08793575 +2.7.1.203,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.204,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.205,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.206,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.207,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.208,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +3.1.1.99,"The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway.",384,1.0,-0.06918002,-0.069201104,-0.10184646,0.0034888654,0.011168834,0.059877887,-0.07058742,0.05014257,0.033696663,-0.048377216,0.036685754,0.0279094,-0.04445397,0.09927281,-0.06345884,0.10764157,-0.071808755,0.013135989,0.012637726,0.016166542,0.08832214,0.071024545,-0.08831978,0.04849316,0.04937108,0.035096284,0.021497512,-0.007692865,-0.059755053,0.045273468,0.009877195,-0.04435469,0.048693363,-0.044277206,0.038737394,0.08775515,0.021196041,-0.047216106,0.07251283,-0.05670528,-0.00081151834,-0.012123364,-0.05495477,-0.03986262,0.016220199,0.020142851,0.05865792,0.049542416,0.08136373,-0.094210155,-0.08402956,-0.03479101,-0.012244748,0.027606308,0.053674236,0.070189066,0.035947826,0.023743642,-0.025493577,0.0155710485,0.00015706717,-0.010740197,0.018176766,0.021371558,-0.01663067,-0.002675288,0.057452377,-0.043038152,0.015831465,0.008592535,-0.08971991,-0.049754795,0.004016903,0.0060647475,-0.031594988,0.023891054,-0.03120798,-0.025987128,0.041009247,-0.055241026,0.023244515,-0.026117155,0.024341881,0.07514338,-0.020603988,-0.038998257,0.09179106,-0.039122134,0.08269357,-0.018814463,-0.013835313,-0.04010921,-0.0336171,-0.06596121,-0.034255236,0.020564707,0.0038353046,0.042781733,0.025527488,-0.020398173,0.0074206116,0.02063971,-0.01946796,-0.13084123,-0.048776254,0.021536205,0.053422846,0.09131361,0.028746292,0.053399347,-0.014215689,-0.006828769,0.0022161156,-0.0087948395,-0.016793417,0.08011439,0.06313965,0.0021325566,-0.13345014,0.040681016,-0.035277043,-0.023960557,0.016293792,0.055206507,-0.022076162,0.027175171,-0.11458926,-1.2179488e-33,0.09077501,0.011933722,0.03248168,-0.07785025,0.014442833,-0.022048352,-0.09582427,0.034797914,0.036078192,-0.0015551504,0.009151095,-0.11939929,-0.03542812,-0.01791299,0.006975135,0.016035562,-0.030421432,0.0033102832,0.05483461,-0.0007860712,-0.00960851,0.027255552,-0.06961671,-0.05547425,0.06556274,0.060438,0.057652444,-0.028325163,-0.04564412,-0.0019647249,0.052425187,-0.074000426,-0.1736116,-0.06483347,0.06134097,-0.045401152,-0.027921543,-0.004902318,-0.004916287,0.052309602,0.013756297,0.036201235,-0.004255901,-0.035835847,0.08207459,-0.08151391,-0.024519645,0.15929298,0.03735328,0.09357001,-0.051900625,-0.09278253,0.06604316,0.066227466,-0.018232198,-0.056873288,0.014202811,-0.0019247133,0.024816373,-0.025837936,0.033599135,0.0057031945,-0.0540806,-0.030164905,0.012501026,-0.009974597,-0.06658796,0.03713274,0.017606774,0.009939883,-0.06445593,0.020006603,-0.062408626,0.011118746,-0.046703044,-0.096562415,-0.03830326,0.026709575,0.047368307,0.018282432,-0.07590767,-0.08337428,-0.006586796,-0.05838292,-0.09703862,0.05200652,0.019664664,-0.024278995,-0.092686884,-0.038524896,0.06516101,-0.09551398,-0.03201613,0.07002997,-0.0015547064,-1.7295218e-34,0.023264088,-0.036806855,0.06875605,-0.062024187,-0.014366282,0.009597931,-0.057808675,0.07083528,-0.0092450455,-0.008790204,-0.041307744,0.009457709,0.05962827,-0.06334191,0.006688827,0.029837271,0.027796146,-0.025428986,-0.031142147,-0.0088918535,0.0015280374,0.09249803,-0.02611519,0.033830058,0.0445828,0.050504122,-0.007930691,0.10528248,0.06258854,0.11447842,0.029462485,0.036312234,-0.06252984,-0.015237653,0.0062592034,0.009982827,-0.023089489,-0.0045844973,0.06427663,0.016557382,0.081255004,0.023263823,-0.0135068465,0.091001324,-0.021120802,0.060808595,-0.06369671,0.030278908,0.046095278,-0.12153959,0.034674298,0.016928542,0.018518265,0.03465406,0.023575325,0.009296934,-0.021500142,0.006621625,-0.11130501,-0.06049821,-0.028111156,-0.061750174,0.009352654,0.02615132,0.0059687323,0.045682993,-0.0054822275,0.04515165,0.0013971028,-0.029440472,0.023901818,-0.019341499,-0.030762365,0.02736063,-0.09448589,-0.019540967,-0.09526982,0.0065704514,0.026219444,0.04541841,0.05097263,-0.015511417,-0.037497155,-0.10726581,0.06548673,-0.05285654,-0.00970948,0.0939846,-0.0529667,0.00671049,-0.03560712,0.025008999,-0.05598772,0.050362643,-0.011470832,-2.165147e-08,0.05451223,-0.051667646,0.08556542,0.035023328,0.0008184806,0.009591582,-0.00040839694,0.08057494,0.03690034,0.00887867,-0.035851847,0.04211203,-0.022632807,0.014138491,0.05488394,0.0062015913,-0.06677978,-0.005061971,-0.027917191,-0.016518755,-0.0486782,-0.10221831,-0.10693186,0.032942444,0.015080694,-0.05164124,0.089375004,0.039835464,-0.0066085593,-0.024533851,-0.008850305,0.01616711,-0.005275645,0.009434914,-0.06680231,0.058435854,0.004675446,-0.019435735,-0.010548131,0.045092907,0.002717951,-0.003903292,-0.093187556,0.004208373,0.06402032,0.027748361,0.07533794,0.029892266,-0.05120643,-0.061363667,0.06950785,0.00046853683,0.009323227,0.0032938172,-0.11083766,0.034048464,0.02161571,0.03445925,0.00080777,0.07066651,-0.022321947,-0.0053876936,0.13572909,-0.00067717175 +3.1.3.99,"The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+.",384,1.0,-0.07983738,-0.08359135,-0.029089727,-0.051259276,0.07524662,-0.0028003028,-0.0073019564,0.009594968,-0.029467616,0.027894782,0.009776916,-0.026892027,-0.10607034,0.06917757,-0.08293369,-0.030484976,0.0025436918,0.015329192,0.07752255,-0.022824343,0.05349144,6.408523e-05,0.004557424,0.0022555115,6.4725464e-05,0.020469697,0.017028278,-0.005226147,-0.03244984,-0.058981076,-0.08258041,-0.032033294,0.036597017,-0.049223468,0.056494527,0.12062011,-0.027386354,0.018917862,0.033957142,-0.017129196,0.030976772,-0.050386965,-0.022547346,0.073581934,-0.038597945,-0.06508234,0.029155657,-0.030885661,-0.012308295,0.057742704,-0.050916173,-0.012682744,0.0802479,-0.05766993,-0.04892256,-0.05783308,-0.07143413,0.031507522,-0.02043437,-0.011233565,0.020183222,-0.027314657,0.020350395,0.011519291,0.019126808,-0.004934815,0.07113886,0.011963571,-0.0054267095,-0.028133852,0.05755727,-0.0469821,-0.007836261,0.07831467,0.0054063573,0.046305716,0.05521593,-0.10719979,0.039363023,0.04470891,0.0028895962,0.0052986876,0.030928465,0.003854983,0.08831522,0.05048032,-0.019034367,0.13054913,-0.016549086,0.007212141,0.033120032,0.057541348,-0.03316438,-0.0390447,-0.0026105556,0.06413648,-0.061368883,0.062147807,-0.0070823138,-0.018987356,0.06073791,0.0765374,-0.07221377,-0.024486257,0.02918925,0.036564376,0.0640258,-0.051564902,0.009848849,0.034445155,-0.00805057,-0.00833329,0.025738541,-0.021166047,0.030604417,-0.007517415,0.021161273,-0.045996677,-0.027254904,0.007977182,-0.013203048,-0.022106875,-0.012315318,0.09204729,-0.083102755,0.07350309,-0.039593484,4.191505e-33,7.3660885e-05,0.037225936,0.02574944,-0.011491709,-0.027514061,0.07198993,0.0012125231,0.0037183047,-0.09868509,-0.040663026,-0.0559312,-0.05473347,0.013940264,0.002589494,0.013245868,-0.027361,0.05057088,0.009216593,0.12126602,-0.0629412,-0.009058231,0.043322347,-0.074354015,0.04734308,0.05824006,0.06943505,-0.049140446,0.008645601,0.07849605,-0.03972757,0.029391633,-0.08982482,-0.07306349,0.026967099,0.055877525,-0.07118357,-0.058866926,0.055195916,-0.05613955,0.023108013,-0.032637794,0.04857178,-0.022735296,0.026623739,-0.00307677,-0.0618883,-0.062267933,0.040740095,-0.027042916,0.028060153,0.034905203,0.036552694,0.028532535,-0.06912933,-0.028442975,0.07072022,0.009880056,0.02230646,0.047090575,0.05319929,-0.03236373,0.04971663,0.043797527,0.013621783,0.015198565,-0.008977565,-0.06807194,-0.047436904,0.020687805,0.10386808,-0.06950804,-0.04554277,0.0044408995,0.008336097,0.017377207,-0.010045209,-0.076567985,-0.02104239,-0.020846149,-0.015882336,-0.0030848936,-0.12094347,0.05431403,0.030276028,-0.101601005,0.011241848,0.01720702,-0.013431107,0.003359314,0.0001284917,0.08942553,-0.03942192,-0.07131408,-0.012803967,0.0064242287,-6.0863498e-33,0.08309629,-0.01227351,0.112551436,-0.10428106,-0.15245964,0.072629526,0.053496893,-0.100392945,0.03854408,0.018121395,0.09428006,-0.05611013,-0.011816833,-0.058755353,-0.014903446,0.09510018,-0.072502136,0.1169402,0.0403501,0.008819558,-0.031841855,0.09959907,-0.017611735,0.12657161,0.03905997,0.03748841,0.0017642112,-0.015706688,0.03355822,-0.013950279,-0.04721622,0.04935127,-0.01810773,-0.067807294,-0.029889697,-0.020622453,-0.020755604,-0.025755517,-0.063255206,0.054237228,0.01873818,0.12819998,-0.041803446,0.09922573,-0.065058365,0.03072276,-0.027811643,0.04381276,-0.000987351,-0.061251618,-0.008145829,0.033873487,-0.006821755,-0.035032067,0.11994406,-0.012505261,-0.0069560315,0.01610288,-0.040091638,-0.0371057,-0.015598194,-0.08370833,-0.031858098,-0.049897455,0.07386963,0.059539337,-0.04989224,0.010269833,-0.002608594,-0.03722442,0.0024316877,0.027918633,0.026125472,0.026884342,-0.055276807,0.00010736889,-0.014220218,-0.041206937,0.05035063,-0.032080233,-0.01787698,0.0028281882,-0.012779015,-0.041146148,0.017147668,-0.04647977,0.031071452,0.026226848,0.007449222,0.032594427,-0.019959843,0.0039662025,-0.040814873,0.03838125,0.012406937,-3.9196053e-08,0.05859326,-0.02432503,0.031936865,-0.123462684,-0.048772655,0.016591173,0.03167067,-0.034752183,0.07021982,0.05760577,-0.065230966,0.012801977,0.05266354,0.01726651,0.08854833,-3.859626e-05,-0.021247642,0.00625455,-0.018168645,-0.00031290136,-0.047387913,0.021639952,-0.15616709,0.06311118,0.020232163,-0.022714017,0.026577191,0.06951905,0.003684978,0.018234424,-0.057547912,-0.027497582,-0.00034472393,-0.052278772,-0.004594503,0.09616594,-0.03590616,-0.0052146013,-0.09959825,-0.0028674626,-0.09565102,-0.07583184,-0.017628288,0.011860366,-0.088192835,-0.036356106,0.009578125,0.053321894,0.018273737,-0.024469608,0.009487054,-0.01803866,-0.02936938,-0.07383054,-0.071929075,0.02191341,-0.029316146,-0.045312528,-0.058088895,-0.08507999,0.048049342,-0.07137974,0.16454716,-0.09572587 +3.1.3.100,"The enzyme participates in the thiamine biosynthesis pathway in eukaryotes and a few prokaryotes. These organisms lack EC 2.7.4.16, thiamine-phosphate kinase, and need to convert thiamine phosphate to thiamine diphosphate, the active form of the vitamin, by first removing the phosphate group, followed by diphosphorylation by EC 2.7.6.2, thiamine diphosphokinase.",384,1.0,-0.07194317,0.049683325,-0.10291197,-0.022501646,0.01921724,-0.0077430196,-0.029424163,0.0093546,-0.02340829,0.04987628,0.037921682,-0.10823201,-0.055743553,0.0055194157,-0.005508,0.006286007,-0.06408129,0.010502693,-0.030841466,-0.058682535,0.018977303,0.09187984,-0.051783755,0.012201576,-0.022780236,0.00093166524,0.08737705,-0.04353507,-0.021492966,-0.06302668,-0.123554386,-0.034439046,0.061684363,-0.061116558,0.019546658,0.11669473,-0.040023044,-0.042854533,-0.028458849,0.019065903,0.11177046,-0.0035880404,-0.024444459,-0.057793777,-0.04234146,-0.012065909,0.054499906,0.017018156,0.040611587,0.023480853,-0.105569705,-0.016754303,-0.026491743,-0.029068727,0.008242494,-0.033312052,-0.017424008,-0.016507389,-0.01924223,0.025437545,0.013937136,-0.06732253,0.02046188,-0.011897181,0.08513332,-0.112253346,0.08813777,-0.04462674,-0.036828943,-0.07034942,-0.09573794,-0.05910948,0.042399555,0.031082768,0.004887157,0.07023352,-0.04049708,-0.009715065,0.03769952,0.0074082343,0.02591374,-0.056618415,-0.049781855,0.06206394,0.017359728,-0.040135704,-0.013483843,0.022017447,0.015516747,0.032407437,0.041989103,-0.027771145,0.019078175,-0.0077712736,-0.10814179,0.043518875,0.010113988,0.02112077,0.015930051,-0.034395464,0.010245213,0.05682035,-0.027703548,-0.03874512,0.006514506,-0.038041007,0.012489044,0.09830567,-0.0038843525,0.063963406,0.036403466,0.013529222,0.029355798,-0.012251421,-0.023742296,0.077499926,-0.025423232,-0.08162476,-0.03348387,0.043197054,0.018450167,0.01999924,0.10485759,0.06539432,-0.034066286,0.0010610948,-0.101620615,3.490428e-33,0.051930863,0.09126586,0.015237907,-0.021260334,-0.0099466955,0.0098461695,-0.06148133,0.025675822,0.009697745,-0.10206065,-0.049201276,-0.06945,0.09699112,0.0029351392,-0.03435255,-0.07484016,0.016270574,-0.063049406,0.06868699,0.06514434,0.03222887,-0.001129945,-0.060821753,0.06057993,-0.012370044,0.069981866,0.012925848,0.06942313,-0.016216828,0.010474661,0.03861304,-0.1294129,-0.1040627,-0.045511585,0.11202201,-0.08536737,-0.005185604,-0.004172866,-0.041744284,0.028540203,0.0016040234,-0.008557426,-0.013509245,-0.0048225317,0.016698744,-0.07372032,-0.017945599,0.09773769,0.058903176,0.021892924,-0.016850129,-0.036453273,0.13308589,-0.04957804,-0.041749854,-0.040155325,0.009116615,-0.05148999,0.0024978041,-0.013376552,-0.008144148,0.0042796344,-0.06610149,0.08194089,-0.04250729,0.021468809,-0.105293706,-0.027309239,-0.027895695,-0.0043843975,0.02314958,-0.017777788,0.07491279,-0.015758237,-0.049263097,-0.026553992,-0.054100443,0.03828462,-0.041298356,0.01561528,0.0707767,0.015092947,-0.012491627,-0.002738463,-0.045619573,-0.07553631,0.06415591,-0.021417372,0.03910826,-0.03334465,0.046332337,-0.041908477,-0.025887936,0.0051403833,0.05194091,-5.415331e-33,0.08805966,-0.034302603,0.06755892,-0.07647155,-0.0042218356,0.016217884,0.073549956,0.018455945,-0.00095761975,-0.018162368,0.02970718,-0.000886195,0.056436308,-0.058396693,-0.0025480588,0.042457078,-0.030285656,0.09740516,-0.0023599176,-0.033527624,-0.028459847,0.036052734,0.03795735,0.018464321,0.014689791,0.00014196541,0.004151671,0.0397299,-0.057414416,0.049445502,-0.06696673,-0.0065777395,-0.06833176,0.020556847,-0.08677735,0.013515979,-0.03054219,-0.00022069027,-0.00754383,0.034033906,-0.021550043,0.0012225719,0.018133452,0.052532315,0.021667622,0.103682786,0.028178576,0.02608251,-0.046464577,-0.05856618,0.054033272,0.04876461,-0.008885334,0.039120093,-0.003335866,0.0075406805,0.0047588497,0.06058822,0.07645557,-0.055754095,-0.021732176,-0.14811161,0.06249906,0.0036171565,0.032401524,0.022898296,-0.029926505,0.10359296,0.048664555,0.024013577,0.06445046,0.007318536,0.065610036,-0.042778507,-0.027661683,0.046262253,-0.044131126,-0.010209751,-0.008606322,-0.06415554,0.029727088,-0.06272429,-0.027287042,-0.04498829,-0.06409569,-0.024800507,0.07379351,0.010659696,-0.09511396,0.023638327,-0.118641816,-0.028671166,-0.041075833,0.082225546,0.081664056,-4.299753e-08,0.026199894,-0.043883298,0.0009825527,0.019776637,0.06886306,0.035960466,-0.033552885,0.06817601,0.15918545,0.05027335,-0.038134612,0.044297855,0.05386665,0.05005755,0.07587703,0.014618766,-0.00051072944,0.10097983,0.010594296,0.048000883,-0.017006785,-0.04982778,-0.063469775,0.023619976,0.023827909,-0.048469167,-0.014805349,-0.025724316,0.0054514734,-0.07645651,-0.041323792,0.011179623,0.029516038,-0.0592256,-0.076588586,0.039274592,-0.024978766,-0.019187192,-0.034594856,0.019466309,-0.008689335,-0.02954845,-0.14811386,0.04639312,0.0012265692,0.017282717,0.035853382,0.09845221,-0.04729597,-0.05316121,-0.022331072,0.0009853933,0.01173117,-0.0919158,-0.06707996,-0.0026513857,-0.011327814,0.0023019651,-0.025425456,0.029799152,0.06348437,0.087469205,0.09642434,-0.072387636 +3.2.1.196,"This bacterial enzyme catalyses a reaction similar to EC 3.2.1.33, amylo-alpha-1,6-glucosidase (one of the activities of the eukaryotic glycogen debranching enzyme). However, while EC 3.2.1.33 removes single glucose residues linked by 1,6-alpha-linkage, and thus requires the additional activity of 4-alpha-glucanotransferase (EC 2.4.1.25) to act on limit dextrins formed by glycogen phosphorylase (EC 2.4.1.1), this enzyme removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin without a need for another enzyme.",384,1.0,-0.07053264,-0.08429353,-0.06359999,0.00695005,0.029583216,-0.024596699,-0.03675982,0.025409913,0.05065782,-0.091995865,0.048462443,0.028468251,-0.10852015,-0.007119683,-0.049933184,-0.030845188,-0.07274263,-0.0024623533,-0.012608461,0.012712875,0.1059591,-0.023219733,0.0022604999,0.040437736,0.0471911,-0.020466994,0.04094477,-0.033123,-0.007793724,-0.088929124,-0.008060006,-0.09416314,0.075562716,0.016326316,0.01402705,0.06179136,-0.051272158,-0.10789482,0.0032316218,-0.0096104955,0.0510297,0.013612832,0.0342616,-0.03668733,-0.046778005,-0.039363932,-0.05574184,-0.013976297,0.015578244,0.014241616,0.0062906537,-0.06521365,-0.06564009,-0.0036951602,0.08968548,0.01707241,-0.11407163,0.0038991568,-0.012107328,0.01795396,0.024532404,0.10991609,-0.052628633,0.020876,-0.03606533,-0.087611996,0.120318666,-0.09022904,-0.011817972,0.0093694255,-0.087777086,-0.029670162,0.027381992,0.01245646,0.036386102,0.04697433,0.007925112,-0.028500615,0.01039009,-0.024051845,0.012811039,-0.0002656324,0.052093994,0.084151745,-0.087858036,-0.06063953,0.013298175,-0.010529645,0.046233907,0.10357755,0.06399198,-0.014493741,0.03315229,-0.04185987,0.037711058,0.053285345,0.032758646,0.027547512,0.0309619,-0.0012933608,-0.029170617,0.120160714,0.059458435,-0.047326896,-0.022603158,0.073420025,0.020546434,0.0668284,0.07054501,0.021663731,0.017031526,-0.020658515,0.04132573,-0.03142695,-0.10186703,0.07972088,-0.010955108,-0.05899215,0.016713409,0.030648412,0.04055529,-0.052519415,0.06854914,-0.0005221286,-0.05727244,0.09460316,-0.10428998,2.4829846e-33,0.07160179,-0.010134607,-0.039508786,-0.04926085,-0.0039471393,0.0043806047,-0.06651784,0.011799817,-0.062231135,-0.018082982,-0.091342755,-0.029653208,0.024499284,0.06579527,0.052634984,-0.033308253,0.014789856,-0.038604613,0.07845093,0.049335707,0.043811806,-0.027002495,-0.007737028,-0.050856825,0.043991305,0.053970695,-0.016616397,0.050019465,0.015438628,0.0034144435,0.015967451,-0.0422939,-0.08672374,0.09225128,0.06911382,0.019970581,-0.036052812,-0.060115147,0.06482253,0.071172245,0.014929076,0.058571726,0.005452667,-0.053251304,0.09220217,0.0057303756,-0.0003458795,0.07258737,-0.0006100323,0.122807465,0.03144861,-0.019043772,0.03987084,0.018374715,0.009378422,0.029767077,-0.032547418,0.0038654814,0.021442456,0.053007174,0.011764263,0.10447935,0.01968108,-0.021178752,0.023132447,0.06802107,-0.06612985,-0.049119882,-0.05300023,0.001977201,-0.07527358,-0.03746759,0.07919673,-0.0033546763,0.012531123,-0.039164063,-0.034241855,0.035289507,0.01476234,-0.075941876,-0.033725165,0.017326329,0.050351687,0.0052688182,-0.020797757,0.03811948,-0.014241393,-0.0032708596,-0.0842483,0.03044485,0.022424895,-0.070843644,-0.02434134,0.02117217,-0.044281457,-3.6623125e-33,0.120852366,-0.107987985,0.040149663,-0.105021186,-0.08191512,0.031003742,0.030943787,-0.036131743,-0.0036391986,-0.010616266,0.044176668,0.03460849,0.082896,-0.07869583,0.024776287,-0.03356716,-0.063987345,0.06007093,-0.08447668,-0.006195549,0.06748585,0.08624257,-0.052632045,0.047415156,0.03738009,-0.057378538,0.012403262,0.1117324,-0.013103564,-0.00093455106,-0.025547631,-0.0068965927,0.030614747,-0.0753025,-0.04592656,0.03594323,-0.016178034,-0.029057581,0.023759743,-0.014570544,0.054941017,0.030581445,0.023837795,0.051779725,0.072888516,0.10015166,-0.05881363,0.009696163,0.029749744,-0.03500518,-0.05074628,-0.021526186,-0.005394694,0.07307953,0.006721087,0.025850065,0.048549406,0.006970175,-0.0453055,-0.029424598,-0.04583442,-0.028218552,0.07077147,-0.018861128,0.087572664,-0.0021486273,0.0046120603,0.025186809,0.047896292,0.06240534,0.010578299,-0.06293999,0.0046130354,-0.038013987,0.026003739,-0.027788198,-0.12236761,-0.051063262,0.034047887,-0.035182748,0.05511354,0.011229907,0.026610348,-0.04455976,0.062260874,-0.07026395,0.08011378,0.11153838,-0.041018933,0.026793644,0.0047518825,-0.051850334,-0.017428674,0.025068656,0.02669123,-4.3859693e-08,0.063718714,-0.044094943,-0.01738295,-0.034625825,0.05253067,0.051814113,-0.04649876,0.056238815,-0.040835757,-0.040479805,0.003171258,0.09288395,-0.046781693,0.0037133298,0.030221745,-0.030699275,-0.06138615,0.03954383,-0.04563299,-0.020529196,-0.1393221,-0.01744186,-0.121038266,0.023943689,0.026381267,-0.0795551,0.033660363,0.08407554,-0.048630513,-0.0033532334,-0.022926569,0.055670127,-0.0112605905,-0.043051172,-0.076046206,-0.033743877,-0.050738044,-0.022286762,0.010874369,0.02675246,0.03215929,-0.05429956,-0.027461551,0.018320272,-0.013934053,0.0016312264,0.0068186773,-0.015140376,-0.03976751,0.030848527,0.06605332,-0.043654468,-0.051932633,-0.043891408,-0.0526931,-0.039257552,-0.046691522,-0.054877028,-0.023825089,0.0061035696,0.017480668,-0.0041120313,0.14378464,0.0017528329 +3.7.1.23,"The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC 3.7.1.5, acylpyruvate hydrolase.",384,1.0,-0.053930037,-0.05595926,-0.093317084,0.04624425,0.023634532,0.018844595,-0.062298093,0.011075139,-0.026777867,-0.027607031,0.019026382,-0.07629561,-0.017665694,0.05236437,-0.008588789,0.08972974,-0.124868184,-0.04118412,0.072760366,-0.020957131,0.10017834,0.14558034,-0.07467576,-0.06349268,0.05780418,0.015735352,0.08695056,-0.018346516,0.0028363685,-0.012304834,-0.0005225543,-0.040552713,0.10360064,-0.088326015,0.123241805,0.092579894,-0.030639024,-0.015489138,0.041415382,0.0137946885,0.05694984,0.030506449,0.047960702,-0.049426924,-0.022166677,0.028648237,0.035300355,-0.013098835,0.02017643,0.044151675,-0.06494227,-0.03804019,-0.009400466,0.061758142,0.010937621,-0.010161438,-0.020674132,-0.05435336,-0.053382087,-0.022463648,0.014497153,-0.041901812,0.008080952,0.005843365,0.005695648,-0.030110015,0.019137949,-0.11898232,0.052093524,-0.055647016,-0.028483769,-0.075870425,0.046711445,0.032620545,-0.009071424,-0.0027125292,-0.0064212987,-0.059638184,0.03538183,-0.018779939,-0.053271413,-0.05008547,0.07831479,0.057466183,0.010696705,-0.042330157,0.06199124,-0.027324978,0.058309376,0.05270827,-0.05049765,-0.00806649,-0.014354826,-0.009878802,-0.051606942,0.078772604,-0.011495306,-0.021524593,-0.012993297,0.009029538,0.015323696,0.070568174,-0.07268823,-0.07178921,-0.0010945498,0.06634472,0.012869842,0.13432431,-0.007841219,0.024646973,0.030859977,0.031343047,0.04824958,-0.008039528,0.020567289,0.06444075,0.034096815,-0.052077122,-0.010695719,-0.014092028,0.08683203,-0.051977143,0.03246377,0.050643113,-0.071853235,0.10171212,-0.12334571,2.3227847e-33,-0.006978382,0.0061850348,-0.052328583,-0.013576931,-0.025403311,0.01717149,-0.07783186,-0.02700204,0.0167182,-0.09777342,-0.026288595,-0.059096817,0.09242091,0.026004303,-0.025650688,-0.08274899,0.014242881,0.014965106,0.071347624,0.022007242,0.014837404,0.08420325,-0.032821238,0.023985807,0.022059387,0.032894023,0.0934364,-0.0025734047,0.03512231,-0.0246447,0.024748428,-0.07628644,-0.082778245,0.00094253814,0.04013027,0.02662008,-0.027896121,-0.035511177,-0.015694834,0.11782172,0.022052342,0.05143717,-0.037949085,-0.034627315,0.046909843,-0.053233948,-0.02602708,0.16918308,-0.02141003,0.038914207,0.039867554,0.010939458,0.079189844,0.01743532,-0.032909606,-0.006918727,-0.0031540303,0.033665553,0.07557835,-0.014845233,0.014167404,0.0006376252,0.03400458,0.02170545,-0.05235969,-0.04457357,-0.040505122,-0.043867853,-0.020282952,0.05673403,-0.07239128,-0.0027232207,0.0669508,0.033662554,-0.02563846,-0.103438206,-0.05891576,0.028755587,0.013762243,0.016927412,-0.015683929,0.04301546,0.04677263,-0.01833146,-0.05019991,-0.012810828,-0.032490592,-0.0384616,-0.032180913,-0.011138867,0.07392849,-0.018826082,-0.042899728,0.0984353,-0.011823083,-2.5586023e-33,0.05692568,-0.08714782,0.03541877,-0.062095236,-0.048764717,-0.016341273,0.018305803,0.03666132,-0.046007734,-0.08127891,0.08658752,0.048692875,0.05395438,-0.04436459,0.049155127,-0.026875833,0.07958308,0.027731108,0.010345412,-0.0143416,0.057247974,0.12481584,-0.058801677,0.0050833453,0.030244,0.033700418,-0.026814884,0.04753835,0.038043052,0.08197583,-0.0376115,0.02088752,-0.04876894,-0.009916707,0.019526415,0.11629706,-0.06142762,0.0072370563,0.082559906,0.054568082,0.037065055,0.040138148,-0.01002171,0.12597972,0.0045662015,0.013488738,-0.03793189,0.05443807,-0.009018509,-0.065530986,-0.06855713,-0.015479773,-0.03741003,-0.04842768,-0.0054217814,0.027400043,0.041927703,-0.03273073,-0.00070661213,-0.004070424,-0.051850975,-0.052502785,0.07929856,-0.0028539014,-0.016979862,0.07256284,-0.031090332,0.042315274,0.027242651,0.020908639,0.03382781,0.026451042,-0.023115978,0.007009392,-0.015789503,-0.06655047,-0.03533166,0.003278238,-0.011830045,-0.05216657,0.04548086,0.005174641,0.04334872,-0.07094581,-0.03346791,-0.06717467,0.05401995,0.10383355,-0.073094025,0.006206725,0.0011088112,-0.09867517,-0.076540515,0.007568385,0.07001202,-4.4525546e-08,-0.0055565727,-0.10171328,0.06170725,-0.046158083,0.0071142344,0.030016886,-0.047610227,-0.033082154,0.08194613,-0.09554974,-0.0063839722,0.026249085,-0.021785226,-0.0013057394,0.018846074,0.02387986,-0.05561388,0.05499235,-0.07097715,-0.049408853,-0.07150092,-0.0317451,-0.08557114,0.06248025,-0.015283117,-0.006944288,0.031012861,0.0071218163,-0.0021641576,-0.060708556,-0.062467173,0.03103171,-0.015995892,0.005544377,-0.044788823,0.020642187,-0.0040976354,-0.0015660215,-0.009950039,-0.02649975,0.020720948,-0.06258988,-0.015019117,0.037282713,-0.003924366,-0.009603263,-0.032795057,0.039338488,-0.035900213,-0.022531515,0.058551,-0.067632094,0.01771936,-0.030333677,-0.046959106,-0.010277517,-0.07556531,-0.048477553,-0.046516042,0.03305351,-0.02598657,0.060132165,0.16322304,-0.084278986 +3.9.1.3,"This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- and tele-nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) [4]. The substrate specificity depends on the amino acid sequence or structural context of the phosphohistidine in a phosphoprotein. The enzyme is also active on free phosphoramidate [1,4] and peptide-bound phospholysine [5].",384,1.0,-0.018543234,-0.031300757,-0.103487715,-0.0910782,0.07077945,0.019835144,0.041694175,0.05961025,0.025449572,0.0482321,0.05631774,0.038931485,-0.062309273,0.09900808,-0.03105923,0.017857155,-0.060626954,-0.06105602,-0.00802827,-0.056915764,0.06728062,0.034094915,-0.06569158,0.010094933,0.020986507,-0.045502763,0.07740201,-0.044788953,-0.029370012,-0.007948393,-0.032189295,-0.07651208,0.069935694,-0.014521345,0.040587436,0.100002915,-0.0717498,-0.047301784,-0.006974037,0.05127536,0.057250135,0.014700935,-0.08472636,-0.023537999,-0.038585793,0.039269865,0.009458511,0.085189916,0.03468221,0.042438217,-0.047793657,-0.0029695018,-0.010953043,0.021999879,-0.0445116,0.09680208,-0.0619878,0.008674637,-0.03439804,0.008513962,-0.021928817,-0.012774325,0.06921369,0.022175943,0.13580453,-0.049974553,0.026752412,-0.053448282,-0.011536544,-0.07616908,-0.010831339,-0.037079453,0.042227816,0.052436214,0.028121104,0.016219014,-0.04462989,0.010584497,-0.0059419433,-0.026688006,0.027126309,-0.040426508,0.017709756,0.04395584,0.010390965,0.033182736,-0.03737103,-0.02582585,0.071568824,-0.013891428,0.01067335,-0.09187958,0.004110029,-0.071854554,-0.03935511,0.006787261,-0.023462847,-0.0010952692,-0.06955099,-0.032397106,0.02512057,0.029337423,-0.055645894,-0.0008389584,-0.057458386,0.07758772,0.012623258,0.019989979,-0.03912107,0.024778109,0.023937391,0.018994827,0.10084331,-0.0578417,-0.0042375172,0.061991777,-0.009661886,-0.061307736,-0.02233567,-0.010428029,0.0057123206,-0.014744662,0.059836797,0.12513669,-0.06249735,0.10856394,-0.108248,3.2609844e-33,0.045455582,0.037843216,0.03929343,-0.05705043,0.016642673,-0.023964627,-0.04914165,-0.005311395,-0.027992293,-0.108738065,-0.07439339,-0.03476885,0.08980542,-0.02257339,0.0017192343,-0.050632708,0.026292652,0.08341316,0.11637272,0.061719935,0.0027858643,0.028665327,-0.021256598,0.018686999,0.034705117,0.035081223,-0.084910706,-0.02810786,0.005018051,0.012579429,-0.03311126,-0.030905997,-0.11591223,0.014750424,0.058376398,-0.068342194,-0.11023346,-0.057155084,-0.032740865,0.042346425,0.0104780765,-0.031052237,-0.00801314,0.021072602,0.034202527,-0.07124982,-0.069472715,0.036249608,-0.029937314,0.02341717,0.008794399,-0.043932553,0.099470586,-0.060959067,-0.050509363,0.017299138,0.0016219589,-0.09374346,0.08145334,0.047163058,-0.0029497275,0.036971867,-0.06304276,0.020564511,0.006862706,-0.021957215,-0.08901081,-0.08761057,0.0108940555,0.10744514,-0.05617305,0.035530355,0.06869268,0.062689275,-0.006794938,-0.037449393,-0.08235381,0.026242593,-0.04518765,0.0440502,0.06602549,-0.014654126,0.0052674934,-0.019786112,0.011393946,-0.062674604,0.04727297,-0.10459706,-0.033036035,-0.008206296,0.03618854,-0.061693322,-0.045604337,-0.002093292,0.034610603,-5.2695645e-33,0.09748602,-0.11628454,0.026855534,-0.03867672,-0.030707505,0.016964193,0.00639998,0.03218393,0.047635898,-0.046034634,0.0026067733,-0.03389216,-0.015693396,-0.008439151,0.013673673,0.061595842,-0.027785499,0.098709114,0.043375447,-0.016116062,-0.0010246533,0.015247874,0.07746884,0.08616003,0.058081646,-0.08226595,-0.028111419,0.08075622,0.016008297,0.018207239,-0.08764598,0.010194472,-0.032446623,-0.035594564,-0.0235068,0.05666117,-0.086375855,-0.027751677,0.10952967,0.0045525087,0.05940902,0.024484979,0.081484705,-0.014229551,-0.041148253,0.0896516,-0.052019797,0.07180438,-0.04474943,-0.078208126,0.0153633,0.018935693,0.019151513,0.06373827,0.07153858,0.07871022,0.031311803,0.09847533,-0.022578891,0.00910741,0.00022100686,-0.09368584,0.010002182,0.021724088,0.024080062,0.030798363,-0.024726152,0.0103268055,0.014176212,-0.0019439007,0.0037719188,-0.014507039,0.06089044,0.052785594,-0.017606169,-0.03119467,-0.06293085,0.018653618,0.05102623,-0.023383956,-0.062946245,-0.04445119,-0.043700673,-0.06945853,0.04608697,-0.009696316,0.05389586,0.05849413,-0.031068604,0.0076818736,-0.009415988,-0.0449706,-0.064333856,0.0009380292,0.07143971,-4.5560103e-08,0.10733012,-0.03751303,-0.0032429346,-0.06126852,0.012896421,0.02639276,0.0591609,-0.06590223,0.007489891,-0.04178657,0.038952336,0.039095648,-0.016853644,0.009243339,0.07806009,0.066469125,-0.08844796,0.023204641,-0.01829643,0.008349432,0.020835612,0.009241514,-0.11306621,0.020456297,-0.018581104,0.017608982,0.042884666,0.019330453,-0.009177925,-0.06631335,0.004978169,-0.02982943,-0.032770768,-0.07683733,-0.03430927,0.013542793,-0.10030228,-0.007234583,0.013457514,0.04930549,0.0005115562,-0.010864172,-0.044835668,0.01540181,0.01301512,0.063596,0.050919816,0.047770757,-0.05449036,-0.0014221057,-0.022294149,-0.004825607,0.0036226981,-0.09714241,-0.065737315,-0.036841456,0.0040387255,-0.10140813,-0.038606495,-0.027033571,0.019673312,0.061504036,0.15205178,-0.026841773 +4.1.2.58,"The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway.",384,1.0,-0.06918002,-0.069201104,-0.10184646,0.0034888654,0.011168834,0.059877887,-0.07058742,0.05014257,0.033696663,-0.048377216,0.036685754,0.0279094,-0.04445397,0.09927281,-0.06345884,0.10764157,-0.071808755,0.013135989,0.012637726,0.016166542,0.08832214,0.071024545,-0.08831978,0.04849316,0.04937108,0.035096284,0.021497512,-0.007692865,-0.059755053,0.045273468,0.009877195,-0.04435469,0.048693363,-0.044277206,0.038737394,0.08775515,0.021196041,-0.047216106,0.07251283,-0.05670528,-0.00081151834,-0.012123364,-0.05495477,-0.03986262,0.016220199,0.020142851,0.05865792,0.049542416,0.08136373,-0.094210155,-0.08402956,-0.03479101,-0.012244748,0.027606308,0.053674236,0.070189066,0.035947826,0.023743642,-0.025493577,0.0155710485,0.00015706717,-0.010740197,0.018176766,0.021371558,-0.01663067,-0.002675288,0.057452377,-0.043038152,0.015831465,0.008592535,-0.08971991,-0.049754795,0.004016903,0.0060647475,-0.031594988,0.023891054,-0.03120798,-0.025987128,0.041009247,-0.055241026,0.023244515,-0.026117155,0.024341881,0.07514338,-0.020603988,-0.038998257,0.09179106,-0.039122134,0.08269357,-0.018814463,-0.013835313,-0.04010921,-0.0336171,-0.06596121,-0.034255236,0.020564707,0.0038353046,0.042781733,0.025527488,-0.020398173,0.0074206116,0.02063971,-0.01946796,-0.13084123,-0.048776254,0.021536205,0.053422846,0.09131361,0.028746292,0.053399347,-0.014215689,-0.006828769,0.0022161156,-0.0087948395,-0.016793417,0.08011439,0.06313965,0.0021325566,-0.13345014,0.040681016,-0.035277043,-0.023960557,0.016293792,0.055206507,-0.022076162,0.027175171,-0.11458926,-1.2179488e-33,0.09077501,0.011933722,0.03248168,-0.07785025,0.014442833,-0.022048352,-0.09582427,0.034797914,0.036078192,-0.0015551504,0.009151095,-0.11939929,-0.03542812,-0.01791299,0.006975135,0.016035562,-0.030421432,0.0033102832,0.05483461,-0.0007860712,-0.00960851,0.027255552,-0.06961671,-0.05547425,0.06556274,0.060438,0.057652444,-0.028325163,-0.04564412,-0.0019647249,0.052425187,-0.074000426,-0.1736116,-0.06483347,0.06134097,-0.045401152,-0.027921543,-0.004902318,-0.004916287,0.052309602,0.013756297,0.036201235,-0.004255901,-0.035835847,0.08207459,-0.08151391,-0.024519645,0.15929298,0.03735328,0.09357001,-0.051900625,-0.09278253,0.06604316,0.066227466,-0.018232198,-0.056873288,0.014202811,-0.0019247133,0.024816373,-0.025837936,0.033599135,0.0057031945,-0.0540806,-0.030164905,0.012501026,-0.009974597,-0.06658796,0.03713274,0.017606774,0.009939883,-0.06445593,0.020006603,-0.062408626,0.011118746,-0.046703044,-0.096562415,-0.03830326,0.026709575,0.047368307,0.018282432,-0.07590767,-0.08337428,-0.006586796,-0.05838292,-0.09703862,0.05200652,0.019664664,-0.024278995,-0.092686884,-0.038524896,0.06516101,-0.09551398,-0.03201613,0.07002997,-0.0015547064,-1.7295218e-34,0.023264088,-0.036806855,0.06875605,-0.062024187,-0.014366282,0.009597931,-0.057808675,0.07083528,-0.0092450455,-0.008790204,-0.041307744,0.009457709,0.05962827,-0.06334191,0.006688827,0.029837271,0.027796146,-0.025428986,-0.031142147,-0.0088918535,0.0015280374,0.09249803,-0.02611519,0.033830058,0.0445828,0.050504122,-0.007930691,0.10528248,0.06258854,0.11447842,0.029462485,0.036312234,-0.06252984,-0.015237653,0.0062592034,0.009982827,-0.023089489,-0.0045844973,0.06427663,0.016557382,0.081255004,0.023263823,-0.0135068465,0.091001324,-0.021120802,0.060808595,-0.06369671,0.030278908,0.046095278,-0.12153959,0.034674298,0.016928542,0.018518265,0.03465406,0.023575325,0.009296934,-0.021500142,0.006621625,-0.11130501,-0.06049821,-0.028111156,-0.061750174,0.009352654,0.02615132,0.0059687323,0.045682993,-0.0054822275,0.04515165,0.0013971028,-0.029440472,0.023901818,-0.019341499,-0.030762365,0.02736063,-0.09448589,-0.019540967,-0.09526982,0.0065704514,0.026219444,0.04541841,0.05097263,-0.015511417,-0.037497155,-0.10726581,0.06548673,-0.05285654,-0.00970948,0.0939846,-0.0529667,0.00671049,-0.03560712,0.025008999,-0.05598772,0.050362643,-0.011470832,-2.165147e-08,0.05451223,-0.051667646,0.08556542,0.035023328,0.0008184806,0.009591582,-0.00040839694,0.08057494,0.03690034,0.00887867,-0.035851847,0.04211203,-0.022632807,0.014138491,0.05488394,0.0062015913,-0.06677978,-0.005061971,-0.027917191,-0.016518755,-0.0486782,-0.10221831,-0.10693186,0.032942444,0.015080694,-0.05164124,0.089375004,0.039835464,-0.0066085593,-0.024533851,-0.008850305,0.01616711,-0.005275645,0.009434914,-0.06680231,0.058435854,0.004675446,-0.019435735,-0.010548131,0.045092907,0.002717951,-0.003903292,-0.093187556,0.004208373,0.06402032,0.027748361,0.07533794,0.029892266,-0.05120643,-0.061363667,0.06950785,0.00046853683,0.009323227,0.0032938172,-0.11083766,0.034048464,0.02161571,0.03445925,0.00080777,0.07066651,-0.022321947,-0.0053876936,0.13572909,-0.00067717175 +4.2.1.162,"The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway.",384,1.0,-0.06918002,-0.069201104,-0.10184646,0.0034888654,0.011168834,0.059877887,-0.07058742,0.05014257,0.033696663,-0.048377216,0.036685754,0.0279094,-0.04445397,0.09927281,-0.06345884,0.10764157,-0.071808755,0.013135989,0.012637726,0.016166542,0.08832214,0.071024545,-0.08831978,0.04849316,0.04937108,0.035096284,0.021497512,-0.007692865,-0.059755053,0.045273468,0.009877195,-0.04435469,0.048693363,-0.044277206,0.038737394,0.08775515,0.021196041,-0.047216106,0.07251283,-0.05670528,-0.00081151834,-0.012123364,-0.05495477,-0.03986262,0.016220199,0.020142851,0.05865792,0.049542416,0.08136373,-0.094210155,-0.08402956,-0.03479101,-0.012244748,0.027606308,0.053674236,0.070189066,0.035947826,0.023743642,-0.025493577,0.0155710485,0.00015706717,-0.010740197,0.018176766,0.021371558,-0.01663067,-0.002675288,0.057452377,-0.043038152,0.015831465,0.008592535,-0.08971991,-0.049754795,0.004016903,0.0060647475,-0.031594988,0.023891054,-0.03120798,-0.025987128,0.041009247,-0.055241026,0.023244515,-0.026117155,0.024341881,0.07514338,-0.020603988,-0.038998257,0.09179106,-0.039122134,0.08269357,-0.018814463,-0.013835313,-0.04010921,-0.0336171,-0.06596121,-0.034255236,0.020564707,0.0038353046,0.042781733,0.025527488,-0.020398173,0.0074206116,0.02063971,-0.01946796,-0.13084123,-0.048776254,0.021536205,0.053422846,0.09131361,0.028746292,0.053399347,-0.014215689,-0.006828769,0.0022161156,-0.0087948395,-0.016793417,0.08011439,0.06313965,0.0021325566,-0.13345014,0.040681016,-0.035277043,-0.023960557,0.016293792,0.055206507,-0.022076162,0.027175171,-0.11458926,-1.2179488e-33,0.09077501,0.011933722,0.03248168,-0.07785025,0.014442833,-0.022048352,-0.09582427,0.034797914,0.036078192,-0.0015551504,0.009151095,-0.11939929,-0.03542812,-0.01791299,0.006975135,0.016035562,-0.030421432,0.0033102832,0.05483461,-0.0007860712,-0.00960851,0.027255552,-0.06961671,-0.05547425,0.06556274,0.060438,0.057652444,-0.028325163,-0.04564412,-0.0019647249,0.052425187,-0.074000426,-0.1736116,-0.06483347,0.06134097,-0.045401152,-0.027921543,-0.004902318,-0.004916287,0.052309602,0.013756297,0.036201235,-0.004255901,-0.035835847,0.08207459,-0.08151391,-0.024519645,0.15929298,0.03735328,0.09357001,-0.051900625,-0.09278253,0.06604316,0.066227466,-0.018232198,-0.056873288,0.014202811,-0.0019247133,0.024816373,-0.025837936,0.033599135,0.0057031945,-0.0540806,-0.030164905,0.012501026,-0.009974597,-0.06658796,0.03713274,0.017606774,0.009939883,-0.06445593,0.020006603,-0.062408626,0.011118746,-0.046703044,-0.096562415,-0.03830326,0.026709575,0.047368307,0.018282432,-0.07590767,-0.08337428,-0.006586796,-0.05838292,-0.09703862,0.05200652,0.019664664,-0.024278995,-0.092686884,-0.038524896,0.06516101,-0.09551398,-0.03201613,0.07002997,-0.0015547064,-1.7295218e-34,0.023264088,-0.036806855,0.06875605,-0.062024187,-0.014366282,0.009597931,-0.057808675,0.07083528,-0.0092450455,-0.008790204,-0.041307744,0.009457709,0.05962827,-0.06334191,0.006688827,0.029837271,0.027796146,-0.025428986,-0.031142147,-0.0088918535,0.0015280374,0.09249803,-0.02611519,0.033830058,0.0445828,0.050504122,-0.007930691,0.10528248,0.06258854,0.11447842,0.029462485,0.036312234,-0.06252984,-0.015237653,0.0062592034,0.009982827,-0.023089489,-0.0045844973,0.06427663,0.016557382,0.081255004,0.023263823,-0.0135068465,0.091001324,-0.021120802,0.060808595,-0.06369671,0.030278908,0.046095278,-0.12153959,0.034674298,0.016928542,0.018518265,0.03465406,0.023575325,0.009296934,-0.021500142,0.006621625,-0.11130501,-0.06049821,-0.028111156,-0.061750174,0.009352654,0.02615132,0.0059687323,0.045682993,-0.0054822275,0.04515165,0.0013971028,-0.029440472,0.023901818,-0.019341499,-0.030762365,0.02736063,-0.09448589,-0.019540967,-0.09526982,0.0065704514,0.026219444,0.04541841,0.05097263,-0.015511417,-0.037497155,-0.10726581,0.06548673,-0.05285654,-0.00970948,0.0939846,-0.0529667,0.00671049,-0.03560712,0.025008999,-0.05598772,0.050362643,-0.011470832,-2.165147e-08,0.05451223,-0.051667646,0.08556542,0.035023328,0.0008184806,0.009591582,-0.00040839694,0.08057494,0.03690034,0.00887867,-0.035851847,0.04211203,-0.022632807,0.014138491,0.05488394,0.0062015913,-0.06677978,-0.005061971,-0.027917191,-0.016518755,-0.0486782,-0.10221831,-0.10693186,0.032942444,0.015080694,-0.05164124,0.089375004,0.039835464,-0.0066085593,-0.024533851,-0.008850305,0.01616711,-0.005275645,0.009434914,-0.06680231,0.058435854,0.004675446,-0.019435735,-0.010548131,0.045092907,0.002717951,-0.003903292,-0.093187556,0.004208373,0.06402032,0.027748361,0.07533794,0.029892266,-0.05120643,-0.061363667,0.06950785,0.00046853683,0.009323227,0.0032938172,-0.11083766,0.034048464,0.02161571,0.03445925,0.00080777,0.07066651,-0.022321947,-0.0053876936,0.13572909,-0.00067717175 +4.2.1.163,Requires Mg2+ [2]. Part of a 4-hydroxyphenylacetate degradation pathway in Escherichia coli C.,384,1.0,-0.02056798,-0.09343283,0.058610637,0.020481367,0.023328623,0.013069569,-0.035834957,-0.0013262774,-0.008107128,-0.033675294,-0.016206678,0.0033364552,0.06849628,0.053605042,-0.02293774,0.00092467037,-0.04371769,0.10146736,-0.041557387,-0.007022113,0.09687127,0.0027128318,-0.00622642,0.023667319,0.009928484,0.016400792,0.10743289,-0.048405748,-0.030645018,0.00081566273,0.022969618,0.031164449,0.015999625,-0.09301384,0.091597244,0.11167817,0.06321931,-0.07972924,0.07675992,-0.06999002,-0.012167615,0.018685058,0.08406033,-0.02340959,0.015891766,-0.032640625,0.06631503,-0.030671097,0.043279756,-0.031400062,-0.042291783,0.015821228,-0.044973522,0.013399271,0.099446125,-0.0074677086,-0.060036104,-0.066002026,-0.03318457,0.06736976,0.042295538,-0.013552192,-0.0174774,-0.026317125,-0.02300898,-0.018777667,0.07136411,-0.018099,0.027238248,-0.008528983,-0.0846345,-0.03691868,0.017646503,-0.0073569864,-0.055644818,0.045233563,0.037962712,-0.12870264,0.033440027,-0.008417134,0.02125136,-0.05075643,0.08091169,0.0642294,0.020895833,-0.06405394,0.049793724,-0.025358485,0.048850387,0.12775224,0.032497887,0.05135661,0.09925247,-0.0069558076,0.009428715,0.013758243,-0.003428033,-0.037883773,0.038808256,0.023201136,-0.06222375,0.063513584,0.013070603,-0.004233207,-0.040038127,-0.023971707,0.02245522,0.14331628,0.006453485,0.036349867,0.074270435,0.00010518919,0.0011314392,0.07727979,-0.022261001,0.08137501,-0.0024995238,-0.10361313,-0.06251075,-0.024268419,-0.046647146,-0.028061105,0.03273618,0.047948647,-0.088340335,0.020182889,-0.023261927,8.942204e-34,0.0087654395,0.0059928414,0.0600014,0.0050714426,-0.029430753,0.023510791,-0.063401096,-0.04460533,0.027084101,-0.098744825,-0.0324192,-0.08536861,-0.039050497,0.022061145,-0.005089187,-0.08479043,-0.063469276,0.055492435,0.09718065,0.0009065272,-0.047879696,0.06472165,0.023678133,-0.07228418,0.02047425,0.0585288,-0.0014252372,-0.028148206,0.02962119,0.011821552,0.0099726375,-0.058935195,-0.075902395,0.026953397,0.08968481,-0.06779023,-0.02164953,-0.03721443,0.0007108207,0.039986353,-0.111456394,0.034756884,-0.02787183,-0.025497934,0.0427301,-0.06306027,0.0065773134,0.02873996,-0.06435876,0.07720928,0.061190285,0.026952676,0.02597862,-0.020064684,-0.07655489,-0.004185176,-0.020574516,-0.014459798,0.062390205,-0.031334326,0.039507788,0.106492564,0.021090725,0.012774127,0.11630871,-0.004096233,-0.05166459,-0.05585565,-0.0026117263,0.09870979,-0.018734142,-0.07458105,0.08784243,0.028521344,0.05586545,-0.042817064,-0.08290436,0.05673682,0.054326113,0.008406865,0.00879509,0.003395472,-0.04829341,-0.026649607,0.007676599,0.049513362,0.015822649,-0.050818488,0.011910269,0.085327625,0.059863396,-0.063939616,0.0087985825,0.07349716,-0.016424323,-2.0575445e-33,0.05051482,-0.03576179,0.04754164,-0.032482106,-0.14481811,-0.026819298,0.025013072,-0.008011616,0.034267273,-0.004788953,0.08547278,0.01513057,-0.008344001,-0.06574143,-0.010519915,-0.06528974,0.0331433,-0.013916517,-0.076006755,-0.0033971586,0.07087397,0.023508338,-0.021584818,0.027438661,0.05073485,0.038453966,0.04996022,0.04160386,0.043758735,0.09392442,-0.024928734,0.06427682,-0.017960759,-0.024657842,-0.08820801,0.037337422,-0.026466545,-0.005680112,0.010057432,-0.011906032,0.019567173,0.049252935,0.010003409,0.07892428,-0.0019905865,0.051986534,0.0007423664,0.075107835,0.049919143,-0.105454005,-0.0394805,-0.06745896,-0.06423883,-0.06507732,-0.015380903,-0.019475015,-0.013321734,0.0038986253,-0.021254815,-0.039305568,-0.044241138,-0.030027194,0.10498852,-0.045605257,0.011360668,0.020955293,0.011773424,0.044209845,0.03447703,0.012384177,0.064396404,0.03967122,0.07159874,0.025051106,0.064279675,-0.01098175,-0.08920002,-0.037989464,0.002385622,-0.029059997,0.02763286,0.04291373,-0.053491753,-0.06870992,0.038050313,-0.12426683,-0.022447813,0.11787546,0.031873982,-0.02577728,-0.01568508,-0.03317525,-0.07246907,0.0010814923,-0.0073439577,-2.6179515e-08,-0.040967196,-0.07978418,0.04313663,-0.06712742,0.001901679,0.0601904,-0.062055215,0.015070963,0.1119266,-0.05781888,0.020396564,0.039522763,-0.062394537,-0.009496269,-0.05686052,-0.019694483,-0.09149037,-0.043036997,-0.019526795,-0.024474123,-0.07862269,-0.06524395,-0.10874753,0.058152072,0.020847287,-0.06921424,0.0143556995,0.040774498,-0.039436765,-0.066864885,0.061899167,-0.026394514,-0.0076508983,0.0049567944,-0.020977804,-0.013413699,-0.02352492,-0.007944627,0.0012796876,-0.0086504305,-0.053764332,0.028872056,-0.032416146,0.0098643545,-0.002277328,0.05398639,-0.053433232,0.06566484,-0.08174005,0.008695873,0.06942584,-0.07069224,-0.050669435,-0.021226795,-0.04778801,-0.040829122,0.04356611,-0.043230005,-0.045165278,-0.07951639,0.017202757,-0.021175457,0.08159698,-0.040854227 +4.2.99.23,"The enzyme, characterized from pollen of the plant Tulipa gesneriana (tulip), catalyses the intramolecular transesterification of 6-tuliposide B to form the antibiotic aglycon tulipalin B as a sole product. It does not catalyse the hydrolysis of 6-tuliposide B to form a hydroxy acid. The enzyme has marginal activity with 6-tuliposide A. cf. EC 4.2.99.22, tuliposide A-converting enzyme.",384,1.0,-0.038356528,-0.05510526,-0.09585374,-0.029806951,0.0765573,0.032696825,-0.03406798,0.00868698,0.0074474704,-0.038401946,0.061798107,0.04181995,-0.12778558,-0.040878244,-0.032400787,0.09661335,-0.015032307,0.04990404,-0.05703,-0.031325497,-0.016057022,0.014575146,0.021609193,0.06521962,0.11545264,-0.07283352,-0.014665869,-0.023613682,-0.06818827,-0.07950653,0.009136338,0.03274881,0.054064248,-0.015766053,0.042340077,0.08007374,-0.05581812,-0.054616477,0.14547399,-0.056596395,0.048706908,-0.05396498,0.033534408,-0.061072562,-0.005297423,-0.030999895,0.004093418,0.04701231,0.08301154,0.034801688,-0.05274962,-0.050769392,-0.09796466,-0.03996833,-0.001405647,0.041126158,-0.035142757,-0.034036748,-0.027106902,0.08071818,0.055753328,0.014073458,-0.03769724,0.07060459,-0.07908459,-0.09259238,0.02905317,-0.0046755853,0.07326916,0.03809951,-0.051084343,-0.05250406,0.0027337964,-0.00029929937,-0.006161587,-0.031293415,-0.030197637,0.0054232636,0.03815168,-0.011019789,0.016652834,0.08310594,0.025554826,0.06910077,0.034738548,-0.045645826,0.018423265,0.05022815,0.05190659,0.02573604,0.061766777,0.017967252,0.017759202,-0.06274624,-0.0020901277,-0.013940853,0.0026677188,-0.022555862,0.0013793687,-0.0003880428,0.021627877,0.060442965,0.01141816,-0.08463333,-0.024721961,0.030342093,-0.0071425634,0.039286103,4.29831e-05,0.04302754,0.01786881,-0.02787614,0.028827637,-0.06071511,-0.06426014,0.053388026,-0.013954053,-0.10065602,-0.034471333,0.005361857,0.032084305,-0.038936768,0.067879096,0.036920507,-0.01003415,0.06128665,-0.028511062,3.4417178e-33,0.044579197,0.037354045,0.018233964,0.014831958,0.00026082853,0.029903501,-0.037436593,0.0076040556,-0.12054813,0.030619372,-0.1491278,-0.0723944,0.0065859803,0.057584368,0.04766968,0.0058125644,0.05686462,0.01104857,0.05221195,0.014986153,0.03628944,-0.01063841,-0.13007987,-0.056441113,-0.040142793,0.016402375,-0.021240758,0.049927708,0.031206384,-0.0054211193,0.070147686,-0.017171487,-0.050946284,0.09321277,0.026904749,-0.04921995,-0.07781352,-0.058999,0.08384583,0.10631218,0.0010193854,0.06526979,0.056324106,-0.0042869565,0.04199698,0.036655173,0.020400569,0.06007902,0.061805654,0.02079773,0.049488503,-0.044977378,0.11812338,0.022378182,0.059759755,0.03153633,0.011317976,0.08939376,-0.004984256,0.037964363,-0.014449894,0.02146824,-0.03533936,-0.014338021,-0.08270046,0.023589257,-0.024822466,-0.036449596,-0.004265813,-0.0045690453,-0.041472252,-0.013772339,-0.03872096,0.0016189404,0.029426677,-0.053409815,-0.00413416,0.00095990486,0.01169787,-0.018642962,-0.012325837,0.03093692,0.059124317,-0.014423823,-0.06183365,-0.011901734,-0.092160895,0.036548026,-0.020971188,0.008014235,0.049666602,-0.065977104,-0.08310617,0.020417273,0.04234209,-3.0487678e-33,0.0568112,-0.06534486,0.00040755168,-0.064726464,-0.125085,0.02439829,0.035749197,-0.029941699,-0.001991797,0.061629456,0.023557076,-0.004792287,0.07077828,-0.061915312,-0.014720486,0.006377548,-0.0006767024,0.07031707,-0.025318518,-0.029021252,-0.09924383,0.07295311,0.06095091,-0.056553554,0.01701846,0.016112247,0.05039916,0.020367038,0.041753855,0.013650125,-0.008338935,-0.0682461,-0.07912929,0.038208857,-0.06394655,0.076591976,-0.020551696,-0.0504392,-0.030690726,0.027918791,0.012374041,0.005910037,0.07003983,0.043265946,0.051035166,-0.0351574,-0.10420703,0.04937459,-0.057489883,-0.06283815,0.011401907,0.026732376,0.054526754,0.0638484,0.038992282,0.0018466621,0.043482155,-0.059362795,-0.066866845,-0.09273249,-0.0072366297,-0.063390814,0.01609306,0.023220757,0.0394738,0.09165604,-0.06717823,0.12633517,-0.00837384,-0.026677271,0.03722484,0.043615263,-0.07053896,0.010591565,0.0057697603,0.0020904224,0.00631031,-0.049184207,0.01753339,-0.017841207,-0.010812491,-0.043059897,0.0072039305,-0.04558038,-0.023894874,-0.092517026,0.05653858,0.09360501,-0.009548206,0.09735169,0.01840132,-0.027258255,-0.01804944,0.08246741,0.08414451,-3.8596756e-08,0.01641958,-0.1080797,0.05141313,-0.106854014,-0.0074650836,0.050691325,-0.0074688005,0.008592517,0.0054255812,0.0009129963,-0.15873487,0.065687954,-0.01002459,-0.014404156,-0.01231498,0.040603288,-0.0049625696,0.028981218,-0.04632586,0.0139054665,-0.024780832,0.042675514,-0.13688438,0.044257253,-0.014407067,-0.022292081,0.016902765,0.024734316,0.03279096,0.016444584,-0.032669514,0.015951766,-0.049954906,-0.005080518,-0.04856995,0.017660439,-0.0044267457,-0.06999664,-0.011615574,0.00050461374,0.025524728,-0.05436837,-0.08178606,-0.031051954,-0.03659384,-0.019322436,0.0022747754,-0.007667446,-0.012449343,0.06675655,0.092449695,0.0108061815,-0.0138879,-0.038323447,-0.058324818,-0.04196217,0.024324806,-0.06432666,-0.008418433,0.023955338,-0.022889515,0.017507961,0.19109608,0.000958682 +6.3.1.20," Requires Mg2+. This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid [7]. The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [6]. Lipoylation is essential for the function of these enzymes. The enzyme can also use octanoate instead of lipoate.",384,1.0,-0.08781105,-0.08664413,-0.034682278,-0.018691536,0.019786248,-0.041325092,-0.058872808,-0.008796315,-0.07494104,-0.024338597,0.017146986,-0.01385369,-0.062098745,-0.0128813805,0.042440515,-0.020965373,0.030512508,0.04851402,0.0250231,-0.05714981,0.1248732,0.008451506,1.4848679e-05,-0.03583222,0.0018124306,0.05661975,0.053604636,-0.018098,0.010232063,-0.03140044,-0.006507996,-0.06945942,0.09629367,-0.14272305,-0.032384597,0.106617674,-0.03184595,-0.0026555746,-0.005744847,-0.02581219,0.010442771,-0.021026788,0.03279866,-0.03568503,0.060762316,-0.119424105,0.10534462,-0.022476276,-0.008991456,0.07054292,-0.03651326,-0.034496274,-0.08094363,-0.0071622483,-0.007629662,0.01403566,-0.050624866,0.041430347,-0.057881113,-0.03552673,-0.01385806,-0.010637984,0.014216238,-0.01432417,-0.02230894,-0.090075254,0.076166585,-0.07611017,0.025069747,-0.025991125,-0.027851425,-0.071996115,-0.008798302,0.006212687,-0.061450087,0.07052777,-0.018003352,-0.081053965,0.03521538,0.050649654,0.0829788,-0.0671945,0.023353893,0.08494853,0.026491998,0.0055604377,0.016923808,-0.026222434,0.012495661,0.08199045,0.04158459,0.062991105,-0.007919355,0.043044563,-0.070323385,0.015560672,-0.016840514,0.037858773,-0.026496356,-0.052939326,-0.0069713905,0.056503013,-0.03783536,-0.038593654,-0.017869912,0.027143845,-0.03207284,0.032091163,0.00026248727,0.020260464,0.048748694,-0.0016926473,0.034370665,0.055816498,0.016030112,0.11085275,-0.05293987,-0.12558357,-0.052044228,-0.0058520897,0.0134860845,0.013319963,0.069990054,0.039475366,-0.028496731,-0.0032618935,-0.063808724,4.2494308e-33,-0.022453452,-0.025014196,-0.014839129,-0.005541145,-0.016080093,0.0010186963,-0.1174066,-0.01596949,-0.011053077,0.034580685,-0.03522141,-0.072251745,0.069345236,0.06007206,-0.046393927,-0.028242879,0.035442498,0.086440355,0.08872053,0.04237268,0.026685772,0.05777379,-0.0054605263,-0.007489948,0.041890763,0.101769716,0.029419445,-0.028307864,0.045334224,0.0053086104,0.029237607,-0.14158197,-0.02641799,0.0039722496,0.06702631,-0.01435255,-0.056578908,-0.059098016,-0.010646975,0.016754225,-0.030635435,-0.010492124,-0.034330986,0.036149893,0.001064276,-0.04961414,0.0010263019,0.088238895,0.07392698,0.009569688,0.10418152,0.010718331,0.042222742,0.06264768,-0.069960475,0.020830994,-0.0769421,0.030326054,0.066232875,0.009828231,-0.017926443,0.017757868,-0.020266905,0.03462316,0.057974845,-0.011005809,-0.10658226,-0.05334059,-0.0023046825,0.055293504,0.045823563,-0.074857436,0.103798635,0.06321008,-0.016474653,-0.02950161,0.0017850414,0.082033046,0.07140847,-0.0017186287,0.031171614,0.034169685,-0.0058197975,-0.052064218,-0.05634285,0.061989143,-0.07372851,-0.0406952,0.057006232,0.054351527,-0.015240191,-0.021979995,-0.037147146,0.013993104,-0.013594918,-5.2662885e-33,0.041505292,-0.059593108,0.025823584,-0.06800065,-0.061241522,0.09810709,0.06371041,-0.05488408,0.10055446,-0.07752691,0.01828944,0.0039446615,0.0047780257,-0.03510781,0.026626159,0.023007236,-0.049966216,-0.016564798,-0.062129196,-0.06408779,0.041890513,0.029837951,-0.0065773544,0.08357075,0.05858111,0.04593473,-0.033967525,-0.03298844,0.050411787,0.07532097,0.010166941,0.01001454,-0.08221039,-0.031082196,-0.029637692,0.09572105,-0.02668441,0.0070619867,-0.037359484,0.08691397,-0.044527408,0.0028391175,0.043966282,0.015760437,0.025721155,0.012894209,-0.041962013,0.05149047,-0.00440572,-0.07303466,0.019096978,0.014229556,-0.05071724,0.012347894,0.09288219,0.045722798,0.0066755135,-0.015776517,0.04447958,-0.052526765,0.0066208793,-0.06085123,0.0706192,0.014103808,-0.007313654,0.07216166,0.07116903,-0.0029481163,-0.018990427,0.051146243,0.065081775,0.015446077,8.0120335e-06,0.05648395,0.03439065,0.08736728,-0.04673545,-0.04144189,-0.03856757,-0.07430116,0.014801644,0.03137723,0.001768979,-0.057803303,0.005449601,-0.10259758,-0.016713135,0.08976023,0.04353779,-0.032617167,-0.048095904,-0.0960182,-0.088608235,0.010834824,0.0361472,-4.1981878e-08,-0.07774231,-0.070856504,0.0657788,-0.03504842,-0.10044755,0.0300675,0.06814887,-0.04077758,0.064266786,-0.104878075,0.028034376,0.054737452,0.012750885,0.02386507,-0.016257042,-0.022721995,0.020870263,0.066490754,-0.041883312,-0.081728615,-0.09116541,-0.054833617,-0.12062301,-0.0125948265,0.012455452,-0.05153749,0.018762566,0.10542386,-0.018081503,-0.026908496,0.017127234,0.009878908,0.051064674,-0.03645687,0.0028746778,-0.015870193,0.026692228,0.030294752,-0.10752069,5.4274587e-05,-0.042351406,-0.054510515,0.04516236,0.0015050654,0.01093437,0.005201073,-0.032898277,0.071081206,-0.014957379,0.049126595,0.006303877,0.008517598,-0.036281034,-0.03351995,-0.042333756,-0.018407397,-0.014424117,-0.053272612,-0.0029358554,-0.041805778,0.037699122,0.01195788,0.1548503,-0.073987365 +1.1.1.395,"This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation. The enzyme has very little activity with unconjugated bile acid substrates. It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA.",384,1.0,-0.022414405,-0.12365622,-0.051781256,-0.0325686,-0.00075804064,-0.0013405944,-0.061946634,0.061481062,-0.02360963,-0.014291318,0.0142541295,-0.004168636,-0.014556739,0.053429663,-0.05184963,0.06166319,-0.05201821,-0.03185986,-0.0012392871,-0.05358813,-0.006202748,-0.025257854,-0.024378171,0.0055987453,0.06443735,0.02428732,0.116591506,0.0009494229,-0.0444319,-0.08593572,0.017424293,0.01250847,0.08254107,-0.055096947,0.013804766,0.0644667,-0.003779635,-0.008007987,0.07397333,0.023649044,0.028788151,0.0013670644,-0.03765429,-0.07653665,-0.029547255,-0.018900033,0.022157451,0.029733364,0.03638195,-0.007254678,-0.055550452,0.007187192,0.00017829097,0.04482928,0.030367553,0.01532212,0.014772951,-0.11450105,-0.04513956,0.011080854,-0.011289599,0.005588234,0.06049866,-0.01801929,-0.02832788,-0.07774106,0.064076975,-0.07225838,0.04083884,-0.06281708,-0.058505714,-0.06342685,-0.02169836,0.014955555,-0.043433532,-0.0008872043,-0.015889838,-0.09597856,0.053042565,-0.07043511,-0.019915167,-0.04839204,0.007002562,0.10056348,0.043849975,-0.06780346,0.019063516,-0.018926997,0.011502322,0.028588135,-0.015707713,0.04972394,-0.038413875,-0.08905549,-0.06553586,-0.018005546,0.037235957,0.04714845,-0.01257008,-0.0020608816,0.02114199,0.1084034,-0.02422034,-0.12234939,-0.037578315,-0.041576512,0.061444763,0.112078205,0.033540547,-0.031536,0.032929305,-0.038943358,0.04548326,-0.025947938,-0.08485435,0.15298112,0.04705997,-0.040374067,-0.062419895,0.104276545,-0.018557915,-0.00335223,0.040029302,0.06372535,-0.030556465,0.015511846,-0.007265799,2.3239639e-33,0.039005782,-0.03440194,-0.017048188,-0.037776154,0.016608467,-0.028010739,-0.0662438,0.02346477,-0.005457168,-0.08534781,0.037345834,-0.011564333,0.023973607,0.013732146,0.00607943,0.031146491,0.021187965,0.014331068,0.03639765,0.028220553,0.039930966,0.020964414,-0.05474973,-0.010356359,0.06703396,0.050131235,-0.0075905286,0.078021154,-0.015365163,0.02393565,-0.019071426,-0.056727935,-0.065528125,0.0031058316,0.08457238,-0.004782336,-0.09881532,0.03120247,-0.003812125,0.07349941,0.0518715,-0.036122583,-0.003865573,-0.016668757,0.012897288,-0.026274914,0.019059436,0.09917849,0.044671305,0.0638405,0.08825679,-0.03330068,0.06417921,-0.06849674,0.009055804,-0.007696248,0.035831332,-7.1256756e-05,0.025274592,0.0049017086,0.060709342,0.058248583,-0.14994471,0.031743538,0.034626108,-0.06352226,-0.017144978,-0.03355003,-0.04966858,-0.0087653315,-0.09200634,-0.004464427,0.04257815,0.028681772,-0.04172429,-0.0045069424,-0.07803947,0.032133494,0.09373241,-0.05756201,-0.028377276,-0.030807825,-0.0009148394,-0.09953833,-0.06186332,0.071150415,-0.020389799,-0.04337495,-0.11686389,-0.013374437,-0.009383417,-0.03792638,-0.07986335,0.022454638,0.06517998,-5.264442e-33,0.014498222,-0.09264771,0.007436554,-0.07505317,-0.07387572,0.08157514,0.0046400228,0.024927795,0.051576458,-0.036858156,0.06765343,-0.010114237,0.031063622,-0.03247664,0.03511065,0.070179544,0.04268936,0.06887965,-0.048383962,-0.047844704,0.024886232,0.11436572,0.037150376,0.043848056,0.0042135064,-0.007980379,0.017070709,-5.6179528e-05,0.071674176,0.11032271,-0.00011714089,0.00416307,-0.006829455,-0.0148615865,-0.05963601,0.026312873,-0.058708094,-0.026936509,-0.01304481,-0.058165856,-0.0066816034,0.007909897,0.044998176,-0.03147228,0.0021781235,0.048852835,-0.05218178,-0.015251981,0.019509122,-0.00406263,0.039057445,-0.022213973,-0.033731453,0.014840946,-0.037628066,0.091051035,-0.043298267,0.021872744,-0.02751429,-0.122036114,-0.07383839,-0.029571027,0.06897753,0.0061159004,0.0037363218,0.08961783,-0.002292894,0.020163208,0.029651321,-0.09773105,0.031852588,0.051683936,-0.020393318,0.05472821,-0.04706538,0.023590751,-0.06606677,-0.004736942,-0.006088877,-0.013157664,0.008605023,-0.041078366,-0.06170132,-0.052187644,-0.004604291,-0.08855369,-0.07528415,0.076770395,0.027927015,0.029893517,0.019539025,-0.004087957,-0.10611721,-0.016079824,-0.01852075,-3.6784964e-08,0.032823488,-0.1213187,0.008498473,0.0013339453,0.058518283,-0.001915445,-0.004369957,-0.032199837,0.07068135,-0.023545912,-0.0048480625,0.13822825,-0.015479563,0.010203876,0.013632927,0.044648893,-0.0099460045,-0.015974233,0.0087207295,-0.05281536,-0.08443986,-0.07163975,0.0021598774,0.07100104,-0.0006550254,0.005062933,0.034160886,0.017063621,-0.023581423,-0.07843387,0.036418356,0.030122079,-0.049729403,-0.017313518,-0.02444567,-0.0026411728,-0.013550997,-0.025746286,-0.0118733235,0.14101613,0.046976093,0.038063396,-0.12694275,0.01029949,0.040470053,0.026578674,-0.036650147,0.06576375,-0.017500326,0.005732434,0.014663083,0.026452133,0.0046625524,0.018244423,-0.07423807,0.02224664,0.0482707,-0.091731764,-0.033603843,-0.010792199,0.043683596,0.035981715,0.21854264,-0.0014429354 +1.1.1.396,"The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.",384,1.0,-0.045676693,-0.024655664,-0.066838436,-0.050159976,0.057789367,0.045911808,-0.046574242,0.017267281,0.061235946,-0.054854106,0.023444407,-0.048868813,0.0019289694,0.053795703,-0.024309395,0.054277275,-0.16199532,0.019495081,-0.08025826,-0.05919632,0.004201865,-0.0026309346,-0.04038976,0.030937022,0.011551016,0.012304232,0.014419731,-0.008729036,-0.06002116,-0.1064759,-0.04838675,-0.008678569,0.048690297,-0.04291183,0.036633603,0.06278027,-0.011171232,-0.08760997,0.024134453,0.044138815,-0.0010766592,0.024950135,-0.015994495,-0.0419688,-0.04048217,0.030154096,0.010766276,0.051708136,0.018166764,-0.013134948,-0.008392332,-0.022583907,-0.07692171,0.05098714,-0.027745094,0.029022127,-0.033190954,-0.06996725,-0.010331597,-0.011648324,0.013960788,0.007955697,0.028944302,0.03889842,0.00076949305,-0.08094692,0.048195314,-0.06918876,-0.012972664,-0.0183247,-0.07651421,-0.104471475,-0.0011669351,0.03355626,0.022918839,-0.06371893,0.04907664,-0.016486024,0.01350353,-0.015569219,0.004144489,-0.016839186,-0.07068684,0.040334225,0.07423502,-0.030010382,-0.0208252,-0.019502573,0.06785534,0.0065542376,-0.035976782,-0.00018424517,0.014927859,-0.035231087,-0.057448737,0.09655236,-0.03008077,-0.03845161,0.04420193,-0.021982996,-0.043958552,0.024222821,-0.030742519,-0.09050128,0.043831427,-0.006564308,-0.018962855,0.120722435,0.00908028,0.028271979,0.043063242,-0.032850116,0.053975705,0.0042729494,-0.0052913544,0.089437485,0.023082605,-0.046888754,-0.090043776,-0.0031953321,0.023882037,-0.036090516,0.02272939,0.023682272,-0.043498244,0.04353625,-0.11839013,2.264404e-33,0.09214709,-0.039293125,-0.02971866,-0.0044762623,0.014699318,0.012333446,-0.060942605,0.031242762,-0.036356393,-0.07631608,-0.047943674,-0.057190653,0.074020915,-0.03649414,-0.0358914,-0.021212365,0.044596966,0.038276564,-0.04367406,0.004064095,0.022947965,0.07994696,-0.05959025,0.077318564,0.017725995,0.07194526,0.0059380215,-0.010798611,0.118493654,-0.006992494,0.0027785066,-0.06882758,-0.09120337,0.047629897,0.067680314,-0.006138925,-0.03918573,-0.0079065645,0.04117785,0.130036,-0.071106,0.03453842,-0.051019635,-0.027992658,0.0818951,-0.041081797,-0.046543498,0.120109946,0.11128905,0.08158584,-0.055163126,-0.009383291,0.08140672,-0.0318604,-0.057521522,0.019399356,-0.034782093,0.013754036,-0.0077431886,0.059897117,0.0012456478,0.07877687,-0.061555658,0.026247619,-0.017732143,0.010300609,-0.026164005,-0.029174104,0.014249124,0.03993057,-0.10703845,-0.004503897,0.024745751,0.06636697,0.1087728,-0.050563574,-0.0123552345,-0.043398924,0.03444298,0.0005871434,-0.0344778,0.06015186,0.12255234,-0.036731992,-0.08133342,-0.033192303,-0.017858017,-0.059592485,-0.005826021,-0.018746365,0.05898916,-0.07641141,-0.016749138,-0.012160758,0.040490843,-3.449324e-33,0.10054952,-0.06983317,0.042737182,-0.09169037,-0.009376374,0.009246463,-0.034802094,-0.059356492,-0.023353951,0.04247951,0.047646534,0.056510523,-0.05675164,-0.035687923,0.012056799,-0.055404123,0.10710093,0.084851764,-0.041587774,0.016372008,0.007761082,0.039403506,0.06077706,-0.016810134,0.030103754,-0.0082371775,0.0016440002,0.017115382,0.11016449,-0.02632724,-0.056916904,-0.04649245,-0.028950488,0.030068211,-0.017459435,0.05106084,-0.07595653,-0.016391356,-0.008959312,0.01669972,0.037201222,-0.041132487,-0.023460077,0.030475546,0.038106233,0.04713662,-0.0715971,0.04949776,0.0021072885,-0.08675805,0.025223237,0.048865482,0.025244372,0.020303428,-0.00951138,0.0367404,0.10884339,-0.009854563,-0.010761611,-0.031536598,0.0040633194,-0.06512545,0.08534876,-0.0065203602,-0.0167275,0.055283338,-0.020800766,0.06546166,0.04196123,0.008896685,0.016582813,0.028717171,0.060217652,-0.004437638,-0.03996792,-0.09290535,-0.03168697,-0.10962766,0.014380291,-0.058025777,-0.031616904,0.029273575,0.0329916,-0.038830373,-0.025229504,-0.06281261,-0.019198503,0.04522493,0.0010571125,0.017242655,0.002623408,-0.022892445,0.017825868,0.086731814,0.063118875,-4.1940016e-08,0.036389984,0.017074248,-0.008819199,-0.024828508,0.030189333,0.07009248,-0.062469393,0.0019700625,0.09642566,-0.029960463,-0.003274745,0.07717718,0.074554525,-0.029882638,0.002772946,0.02976401,0.0007361317,-0.034366895,-0.0035040237,-0.0021146557,-0.07669623,-0.015425891,-0.13296148,0.06566935,0.0010992123,-0.0088941865,-0.00017666427,0.04276837,-0.04312441,-0.054701813,0.0013971584,-0.0016859316,-0.015462805,0.016217433,-0.014310421,-0.018194253,-0.041951463,0.008522196,-0.025856018,0.049776334,0.08040961,-0.044014607,-0.08244985,0.090125054,0.0766705,0.022703787,-0.039846234,-0.05819318,-0.016034072,0.02172882,0.067354664,-0.03424369,0.036182474,-0.04117415,-0.108800285,-0.006274308,-0.00037129817,-0.12929258,-0.08129518,-0.017373597,0.027785484,0.0036340144,0.19987673,0.053590417 +1.1.1.397,"The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2).",384,0.99999994,-0.0027816857,-0.012305211,-0.16005173,-0.053214233,-0.052607123,0.04395752,-0.019431628,0.055059817,0.0819239,0.0068055135,0.03024646,-0.009869333,-0.0030968871,0.08727769,-0.070125766,-0.0007193605,-0.049413197,-0.036529902,0.07696906,-0.052859966,0.049032982,0.12987277,-0.0014514438,-0.0029666729,0.022755288,-0.04301429,0.02827236,-0.028111832,-0.044537768,-0.022262555,-0.0027755066,-0.03058752,0.037677437,-0.024642011,0.058711592,0.060618464,-0.058536205,-0.00095539796,0.17054194,-0.00328499,-0.05258365,-0.05637518,-0.059117056,0.020695778,-0.011194825,0.036404315,0.062486865,0.08903231,0.009534808,-0.02387113,-0.023417538,-0.037683066,-0.04731465,0.06150128,0.10227426,0.05464454,-0.013042096,-0.010568785,-0.013714583,-0.017924575,0.066858,0.005424339,0.023170874,0.00044094195,-0.057203677,-0.09014301,0.03566018,-0.08635463,0.0674428,-0.014378839,-0.056019258,-0.08188669,-0.008241641,0.07532461,-0.03624893,0.024504604,-0.03988834,-0.026793804,-0.048039764,-0.037726533,0.06657845,-0.031697407,0.029424734,0.12266369,0.036967166,-0.004474716,0.04215431,0.027266689,0.05437538,0.008412333,0.07871554,-0.036968213,0.0048093414,-0.06185659,-0.05821749,0.016464582,-0.074791856,-0.06888915,0.015937757,-0.02479472,-0.008354169,0.0029806348,-0.008945505,-0.04242781,-0.030776603,-0.030172884,0.010745154,0.05204173,0.03388334,-0.03134085,-0.047769394,-0.0027167678,0.011572557,0.0210496,-0.057151034,0.045028258,0.121627614,-0.035035495,-0.055057827,0.0006797283,-0.010507622,0.08032474,0.008191509,0.0741777,-0.021240234,0.023931371,-0.09416266,-1.3631941e-33,0.0351655,0.0045115016,-0.0026988522,-0.06287564,0.05819121,-0.0057915347,-0.08258268,-0.013709009,-0.02530766,-0.03513676,-0.080383144,-0.10999963,0.03826227,0.034618076,0.060936652,0.051988848,-0.11312499,0.021670846,0.049150042,0.010875482,-0.02883326,0.0104557,-0.018090872,0.01064958,0.038115542,0.055466946,0.009580887,0.049320452,0.10611221,-0.043584723,-0.03161268,-0.053580344,-0.07516877,-0.013168745,0.05526316,-0.055141244,-0.031313244,-0.029908422,-0.019362258,0.06643411,-0.031846605,0.04671439,-0.0007311338,0.0044170064,0.050030325,-0.0142004015,-0.034584355,0.10323308,0.04818636,0.053330243,0.07415988,-0.07355897,0.027565286,-0.00039352285,-0.065018244,0.012062087,0.005019084,0.011939448,0.041287262,-0.00063965336,-0.030629506,-0.03275534,0.015327087,-0.0040896493,-0.022877228,0.004718075,-0.049426146,-0.071160235,-0.011838466,0.05055187,-0.114202894,-0.020440605,0.060679916,-0.0032597103,-0.008641223,-0.0057412847,-0.045981597,-0.04022976,0.060374115,0.016829718,-0.026388185,-0.03536304,0.03851088,-0.051707,0.0211557,-0.02296902,-0.07174453,-0.076497294,-0.0031229083,0.0036918914,0.015600513,-0.013139675,-0.13533925,0.084822685,0.010288234,-1.059452e-33,0.065870374,-0.099551536,0.05197968,-0.036678925,-0.008806688,0.076743454,-0.06401219,-0.08189374,0.014699782,-0.056960784,0.088380545,-0.046848368,0.04223137,0.013957569,0.039410394,-0.09386566,0.0059480593,0.06771773,-0.05562035,-0.0054819076,0.03303413,0.033396617,-0.0067072753,-0.051307496,0.04462214,0.016781813,-0.02389424,0.06300668,-0.0152015705,0.06543871,0.054840934,-0.06826945,-0.09079219,-0.013086272,-0.0051534576,0.117567,-0.026577665,0.05020172,0.05823385,-0.039660234,0.07393375,0.02887082,0.038199987,0.06097427,0.005859392,0.05581568,-0.028994028,0.058867265,-0.019426819,-0.07425715,0.019054309,0.032207783,0.024470557,-0.037346993,0.028552484,0.012258207,-0.008478226,-0.017728813,0.0027817271,-0.01625464,-0.05075042,-0.054821584,0.052479867,0.015675904,0.021256896,0.03972587,0.0007281403,0.09327806,0.1053954,-0.039865497,0.06898108,-0.0030419214,-0.028997885,0.07601384,-0.059692178,-0.058609057,-0.070867196,-0.051318582,0.0456416,0.03377611,-0.008349035,0.017584965,-0.017620787,-0.010504468,0.00072387676,-0.053742662,0.013732758,0.10248724,0.05430185,0.049191076,-0.0041026683,0.05337,0.0070618344,-0.0030028466,0.0443887,-3.2948307e-08,0.048244964,-0.07456884,-0.0026517746,-0.048286363,0.025342755,-0.019607585,-0.04358236,0.015326903,0.04352999,-0.06796488,0.0035997373,0.036437668,-0.057764187,0.018439086,0.01065103,0.027024645,-0.067100175,0.021208122,0.0012845785,-0.042743202,-0.08880061,-0.021353876,-0.12720332,0.04206335,0.034111887,-0.07458966,0.024873478,0.026902974,-0.03800473,-0.018506957,0.022991382,0.01362254,-0.024509503,0.017727887,-0.08827091,0.027318768,-0.035246015,0.0004791144,0.009314718,0.020431405,0.054941818,-0.016550073,-0.069694586,0.01145725,-0.0512315,0.03997216,0.015719585,-0.0068225763,-0.039875124,-0.011454786,0.074541464,0.048940547,0.02796952,0.010163929,-0.13330239,0.031255703,-0.027974831,-0.085906915,-0.057787593,-0.04463854,0.008873199,0.0037092282,0.21529311,-0.028008752 +1.1.1.398,"The enzyme, characterized from the bacterium Rhodococcus sp. AD45, is involved in isoprene degradation.",384,1.0,-0.079326615,-0.045332503,-0.047532424,0.03886202,0.06441545,0.025006862,-0.09830148,0.0392211,-0.019478092,-0.07569243,0.01563277,0.009515023,-0.06371863,0.025216067,-0.040142935,-0.028690172,-0.049757954,0.016168961,0.0057752063,-0.014511532,0.058281444,0.0089549525,-0.07626622,-0.0005773656,0.06444901,-0.002317973,0.05229416,-0.030125309,-0.055965677,-0.041556325,0.007395182,-0.11199189,0.09502898,-0.07164241,0.057224356,0.103256814,-0.03909923,-0.05083443,0.09171118,0.007826978,-0.010875268,-0.0417101,-0.011524473,0.013253228,-0.023360854,-0.025188668,-0.03480031,0.04354047,0.025828797,-0.027379015,-0.04724489,-0.01953449,-0.05323269,0.024587365,0.0332421,-0.008276419,-0.0041861697,-0.020747958,-0.063710354,-0.03150148,0.07865502,0.045103237,-0.04571101,-0.021392887,-0.0509499,-0.036236987,0.09014982,-0.04552118,0.06805755,0.06077428,-0.090043984,-0.024203101,-0.048181184,0.043334544,0.00823528,0.03615625,-0.03399605,-0.08065624,0.037359707,-0.03638004,0.030706272,0.031218302,-0.04735131,0.03585277,0.03764521,-0.0152457915,0.06932313,-0.0523723,0.02211454,-0.019345237,-0.008346367,0.05244267,-0.0017228763,-0.05994202,-0.06703692,0.027039308,-0.026497252,0.058055997,-0.009524899,-0.030783514,-0.04652523,0.052708562,-0.072071046,-0.11777398,-0.0441137,-0.03122978,-0.017416809,0.10131311,0.09319654,0.048262928,0.011877431,0.04032287,-0.027880603,-0.02312248,0.01579039,0.0703748,-0.017643208,-0.054725204,-0.09206448,0.009488993,-0.05629288,-0.030540425,0.017558465,0.060045287,-0.034352712,-0.010272189,-0.059455838,-2.179234e-33,0.022025226,-0.062279876,-0.02461194,0.011093902,-0.044649176,-0.009366047,-0.07583774,0.031037427,-0.022555113,-0.07313457,-0.027740799,-0.0836472,-0.013408873,0.047790263,-0.010850458,0.020091983,0.018989112,0.023928262,0.053176,-0.020715559,-0.03158138,0.0489259,-0.06225262,0.0027613342,0.046865836,0.051039062,-0.017404845,0.010844591,-0.02185766,0.002489648,0.0474073,-0.06894606,-0.13243954,-0.00058756344,0.057776824,-0.018693881,-0.021714203,0.0027274122,-0.00862923,0.0025255752,0.033202574,0.049183883,0.02502556,-0.03363768,0.086284004,-0.015315193,-0.019966858,0.1381004,0.050365306,0.054557446,0.02776815,-0.03959785,0.06938855,0.011002029,-0.07502216,0.0005122524,0.010555678,-0.008178514,0.0047383234,0.035245955,0.04239959,0.14609969,0.024933515,0.060800053,0.034772065,0.05921859,-0.040748272,-0.04510439,0.043480698,0.10126196,-0.056126565,-0.034432776,0.03600777,0.016589973,-0.01851431,-0.0583081,-0.022085678,0.02767809,0.11240561,-0.0049803616,-0.08415497,-0.021393128,0.036465943,-0.045345042,-0.061826672,0.0038686795,0.014520689,-0.007418773,0.01632329,0.07887456,0.13901076,-0.09179732,-0.13923654,0.061341133,-0.05861985,-2.4896528e-35,0.09850682,-0.11223754,0.017781222,-0.04692757,-0.09456415,0.038432542,-0.02576567,0.050155226,-0.046534427,-0.06707547,0.0987337,-0.024946975,0.018457374,0.06749195,0.06037298,-0.026854372,0.015358386,-0.04442434,0.0066669607,0.06744925,-0.0104307085,0.05570953,0.020536028,0.028050112,0.02162825,0.0049691508,0.04291353,0.09786943,0.030404039,-0.02377508,0.001635504,0.031907625,-0.0707425,-0.028333483,-0.04247321,0.047980215,0.008545277,0.005368218,-0.012724982,-0.053844802,0.016660346,0.019049682,-0.10682286,0.02573293,0.011739558,0.037371945,-0.015201842,0.011546219,-0.02075593,-0.08378891,0.07584544,-0.019911159,0.010390469,0.026722778,-0.06108644,0.0517225,-0.07426027,0.035444915,-0.011998578,0.005804092,-0.014074539,-0.024385083,0.061655127,0.027356097,0.045734752,0.071801096,0.020674752,0.07312198,-0.024291633,-0.057330117,0.10438664,0.0040722643,0.03796027,0.0006806083,-0.08808024,-0.07492334,-0.038977504,0.008321302,-0.027917612,0.025736421,0.008549972,-0.02487596,-0.055649478,-0.00074114226,-0.054091595,-0.011072193,-0.012144704,0.099126354,0.024031516,0.082782,-0.018305559,0.008268685,-0.08591952,0.027430391,0.10409332,-2.4341187e-08,0.02311749,0.017925004,0.1302243,-0.027399318,0.017854018,0.014221709,0.015351877,0.02791661,0.017046845,0.06698476,-0.01026145,0.062426675,-0.047523256,-0.010222348,-0.03205281,0.0024759935,-0.10065388,0.037054487,0.0009171515,0.026553355,-0.104939185,-0.03680422,-0.079082765,-0.012929223,0.048360627,-0.058086,0.12987253,0.012503486,0.012902313,-0.07056843,0.037063286,0.0030691738,0.0322857,0.042196456,-0.052610807,0.038036242,0.020707969,-0.021993453,-0.06325883,0.06879381,-0.035897892,-0.008559565,-0.09720076,0.0015370627,0.038792066,0.030823577,0.023298554,0.014198614,-0.0056235264,-0.020826261,0.0021775751,0.0040249587,-0.041887734,-0.03665128,-0.08278651,-0.024009246,-0.020282352,-0.010672548,-0.041524615,0.058224753,0.047260914,-0.0018879042,0.17076184,0.0017540884 +1.1.1.399,"The enzyme catalyses a reversible reaction. The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate [1,2]. The SerA enzyme from the bacterium Escherichia coli can also accept (S)-2-hydroxyglutarate with a much higher Km, and also catalyses the activity of EC 1.1.1.95, phosphoglycerate dehydrogenase [3].",384,1.0,-0.06700935,-0.025499085,-0.049464654,0.017115505,0.03649346,0.055010118,-0.07180144,0.037556823,-0.00164911,0.018513747,-0.028658174,-0.04683671,-0.05856173,0.046041507,-0.047113184,0.0121752545,-0.025682725,-0.018227324,0.03251193,-0.03406361,0.08567905,-0.0056336494,-0.056964386,0.041746825,0.061630245,0.05253896,0.045732215,-0.03934244,-0.040069044,-0.07263249,0.050747335,-0.11283677,0.057359025,-0.011041718,0.06208676,0.05459501,-0.025376355,-0.048209056,0.08891677,0.016156837,0.002343494,0.031352084,-0.023394894,-0.09219625,-0.033825558,-0.035530448,-0.012554795,0.10429758,0.041326497,-0.008707524,-0.010817599,-0.009644376,-0.05744436,-0.0046189786,0.028018177,0.024250623,-0.043396242,-0.05176295,-0.0088121025,-0.0061569596,-0.024209043,-0.017850477,-0.013871689,0.021001741,-0.02142743,-0.12942801,0.033815455,-0.11303932,0.025289167,0.0023351582,-0.07650524,-0.06246667,-0.045052517,-0.015221045,0.037467994,-0.009839041,-0.047839038,-0.007555095,0.039790843,-0.041547112,0.04435549,-0.06871254,0.010576239,0.07908852,0.008459536,-0.020115755,0.018628377,-0.0073165237,0.10725521,0.018818842,0.026652656,-0.030274792,0.04681571,-0.018723033,-0.042871695,0.027140906,0.04842204,0.035869528,0.050761312,-0.054058038,-0.049283583,0.08726391,-0.03508685,-0.070986964,-0.042853497,0.0292343,-0.028050395,0.14545673,0.059435073,-0.04503981,0.009575614,-0.009532111,0.04909016,0.030491248,-0.0016675033,0.0985217,0.02699697,-0.11272507,-0.10796871,-0.04253447,0.0045233676,-0.059726164,0.0443928,0.03963476,-0.07345724,0.04879147,-0.060639307,3.347351e-33,0.059140082,0.0055160983,-0.01640579,-0.061275277,-0.032768667,0.016293775,-0.07493098,0.089335084,-0.03256796,-0.035323083,-0.04477691,-0.01270894,0.05208144,0.07053129,-0.026741667,0.003930751,0.0041103223,0.010360113,0.020190286,0.00038724657,-0.025855709,0.032228786,-0.007074829,0.0071629584,-0.005687815,0.07707541,0.006021004,0.017344847,0.046048064,0.004048434,0.059620604,-0.07848855,-0.09723209,0.053405263,0.022588104,0.013649592,-0.037611164,-0.027074918,0.006129368,0.07026889,-0.02395223,0.027747858,-0.044106647,-0.07099656,0.06447548,-0.03959075,0.030715942,0.06313382,-0.0022561331,0.073002554,0.025313314,0.044787314,0.06313894,-0.055851746,-0.020534271,0.02638327,0.051177315,0.05399516,0.08024887,0.0728032,0.018944724,0.14018905,-0.024328958,-0.008284458,-0.024040634,0.005797082,-0.00013823289,-0.054338027,-0.0032140983,0.09769959,-0.0664631,-0.0072185993,0.08414786,0.060340647,0.038693547,-0.09369782,-0.006858464,0.003707791,0.06579219,-0.0037414562,-0.04579727,0.035922583,0.07149842,-0.00047040664,-0.023381874,-0.06439511,-0.03054241,-0.079943866,-0.07478764,0.08919251,-0.024483971,-0.062424336,-0.061362155,0.052997,0.019088604,-4.5502608e-33,0.12779519,-0.11632252,-0.040743195,-0.07740776,-0.114010595,0.05856071,0.05125566,-0.0007407516,0.04733371,-0.0043733814,0.07161397,0.037226655,0.06989551,-0.010906273,0.07757228,-0.033985917,0.007745505,0.0705946,-0.10845916,0.0055794553,0.03513709,0.06431975,0.011425002,-0.0051384196,0.030074222,-0.00015712262,0.02672805,0.06967654,0.07654978,0.02067881,-0.0039847093,0.0133219445,-0.0043980125,-0.02116354,-0.044031966,0.07058756,-0.08467209,-0.00082266895,0.016002212,-0.0025736715,2.7214712e-05,0.031550735,0.014287665,0.038552206,0.080600426,0.029461613,-0.06514473,0.019292865,-0.008542594,-0.062025905,0.011838643,0.02720725,0.009066519,0.04839483,0.02531242,0.022003787,-0.022230517,-0.009139685,0.009952144,-0.041008744,-0.040686056,-0.044104777,0.062112965,0.015914721,0.017951554,0.039173968,-0.006238892,0.01805319,0.0245281,-0.0024837523,0.09002853,-0.04200773,0.0035239053,0.00746157,-0.011412671,-0.004675626,-0.06950818,-0.036755078,-0.0076927757,-0.04376727,0.045217905,0.027955256,0.032682456,-0.0649466,0.038955804,-0.12415221,-0.044092614,0.10498051,0.022793425,0.059539083,-0.017447684,-0.06813176,-0.032060552,0.0029542968,0.11696306,-4.2647976e-08,-0.021274172,-0.059448075,0.10715357,-0.027317813,0.02011577,0.06490414,-0.0031798815,-0.051677294,-0.011690324,-0.059800252,0.022209879,0.03218874,0.009073173,0.007969383,0.009985364,0.0030785222,-0.04523597,-0.0061775222,-0.00025158445,0.03557975,-0.10253958,-0.046430968,-0.09070656,-0.014774664,0.015163991,-0.042886473,0.0055502197,-0.03795895,-0.079203166,-0.036456414,0.018834641,0.03367576,0.017978862,0.024382425,-0.03026792,-0.0567562,-0.025998725,0.00536927,-0.044731934,-0.015173167,0.03311477,-0.009948221,-0.063664384,0.0018763839,0.011843258,0.05214,0.004615473,-0.03911997,-0.07109386,0.0045315293,0.06122253,-0.07401704,-0.025029093,-0.080822274,-0.07846961,-0.008931293,-0.07336448,-0.11369806,-0.0961977,-0.03312695,0.07056404,0.06570621,0.18707076,-0.02732058 +1.1.1.400,"This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.",384,1.0,-0.07074125,-0.02937806,0.013146584,-0.0010927223,0.10061689,-0.01986061,-0.06558338,0.075355604,0.033229012,-0.04142953,-0.045709264,-0.07939553,0.03165188,-0.029556131,-0.037070353,0.04492799,-0.080312245,-0.027023051,0.05806828,0.0062797857,0.07207531,0.068815455,0.0026148567,-0.06501246,0.0020620401,0.09159172,0.044529367,-0.02506091,0.022301195,-0.047438666,0.048428606,0.055281408,-0.014900225,-0.1029781,0.03104048,0.10863764,-0.05955265,-0.012695497,0.058212698,-0.0031805448,-0.023297353,-0.02978576,0.03979214,-0.0716628,-0.037888438,-0.032126006,0.028499706,-0.024490416,0.033847816,-0.0923175,0.051413104,0.018057546,-0.03533074,0.072208114,0.06272953,-0.061037242,-0.034107115,-0.05460577,-0.07094017,-0.029935557,0.036887746,0.09095854,-0.019554628,0.02279984,0.0032666903,-0.028127156,-0.02829062,-0.024326093,0.040522333,-0.07107584,-0.13157861,-0.04113137,-0.009057733,-0.011016952,-0.0035821772,0.03866057,0.057923205,-0.022614963,-0.0040538763,-0.028800052,0.02872474,-0.010395777,0.09934277,-0.0047439113,0.034865443,-0.05112425,0.036638957,-0.04254061,0.096280135,0.0044239205,-2.6122112e-05,0.015578426,0.0028980675,-0.023402875,-0.019739594,-0.0019232624,0.021653874,-0.00518275,-0.0031457562,0.004098317,-0.03959581,0.0684319,-0.124845706,-0.074211806,0.06627396,-0.00634387,0.05545404,0.15397792,0.096243165,-0.0145264175,0.021203378,-0.0040542325,0.031279087,-0.018983958,-0.05334104,0.037414048,0.053599253,-0.07164079,-0.09467463,-0.017552787,-0.040909927,-0.0069622714,-0.0013030263,-0.00629284,-0.04065695,0.034810066,-0.026399191,3.0088743e-34,0.008441326,-0.048338734,-0.04990586,-0.08146326,0.014188623,-0.033483032,-0.041669745,0.022873746,0.010686361,-0.09339562,-0.0765291,-0.0770729,-0.07672853,0.06213962,-0.0333021,-0.03492345,-0.013583441,-0.016505565,0.07568224,-0.06654726,-0.012306997,-0.007983427,-0.04070193,7.693024e-05,0.07073724,0.021575619,0.087839976,0.029289283,-0.02129127,-0.009400082,-0.010376589,-0.05336975,-0.115963764,-0.051008232,0.09119939,0.042574853,0.01748099,0.023243103,-0.05412373,0.066998996,0.0197912,0.021135926,0.00395698,-0.04357288,0.05726638,-0.020880675,-0.0005974798,0.10255507,0.02629011,0.032470305,0.010595262,-0.0026877203,-0.029305378,0.011213147,-0.089351594,0.05631533,-0.0112871565,-0.03662149,-0.0005873659,0.035274483,-0.027850715,0.10434221,-0.038783167,0.03301232,0.0047122096,-0.0026350783,0.028301818,0.0023375426,0.046123866,0.082428224,-0.10295657,0.042776864,0.08971588,0.03169841,0.019351505,-0.048529997,-0.061834037,0.0016327498,0.1055041,0.011787015,0.040435348,-0.09736188,0.044382785,-0.009258518,-0.019043054,-0.040860362,-0.026164602,-0.051431105,-0.015037601,0.040716518,0.088880785,-0.01078406,-0.028608002,-0.034227427,-0.022935152,-1.7984351e-33,0.08000587,-0.047322206,0.033008736,-0.07558912,-0.01546318,-0.009985321,0.021975981,0.008664129,-0.015953882,-0.005359336,0.02452724,0.0432093,0.09785384,-0.11978793,-0.00074219605,0.0005387484,-0.010467907,0.044924065,-0.042445585,-0.058574293,0.021693949,0.03253084,0.019832801,-0.028409516,-0.02537383,0.008557811,0.041355595,0.025444416,-0.022636246,0.025823355,0.04835643,0.112734415,0.03134607,-0.026589105,-0.06754814,0.07110391,-0.0009486703,-0.044746242,-0.016298534,0.004828897,0.087373324,-0.020828431,-0.007176836,-0.004470208,0.015587312,0.009720368,-0.066814125,-0.077952266,0.10404567,-0.037868697,0.06589159,-0.024916567,-0.014564433,0.0089492295,-0.033771418,0.028419241,0.016160678,0.0046995655,-0.008997542,-0.022503583,0.02956022,0.017967423,0.057246305,-0.011557399,0.021333184,0.0033950265,-0.02582316,0.03405699,0.029652052,0.007730918,0.09885061,1.4374875e-05,0.040261913,-0.024644464,-0.022212908,-0.010874584,-0.060734697,0.04561772,0.008887933,0.011392115,0.03469969,0.0063059316,-0.0046864287,-0.06685755,-0.035411768,-0.06964747,-0.0075056483,0.064534925,-0.008539598,0.049939986,-0.050888747,-0.04003751,-0.14119521,0.08717175,0.027729396,-3.5127485e-08,-0.027391238,-0.08182705,-0.055614177,0.059614133,0.0047357823,0.08152121,0.020694733,0.022779517,0.03980886,-0.011829927,-0.033053078,0.100335404,-0.062157135,-0.007964007,0.043914508,0.017387697,-0.047295466,-0.06490187,-0.030951384,-0.040891256,-0.016608953,-0.008931669,-0.010253271,0.06584367,0.08018428,-0.021027433,0.04469916,0.07026335,0.004681014,-0.024417207,0.005655486,0.08632255,-0.084763356,-0.014560946,-0.020908099,0.011196996,0.018855073,-0.038060762,-0.018861137,0.13401541,-0.025015732,0.05125988,-0.08361251,-0.02621984,-0.00017149784,0.0629086,-0.062496796,0.1306309,-0.050527547,-0.07083165,0.078891724,-0.039819546,-0.019868996,0.029190328,-0.06925077,0.050054763,-0.047950488,-0.04073203,-0.04873214,-0.077237956,0.0010808598,-0.015688356,0.20541152,-0.028849453 +1.1.1.401,"The enzyme, characterized from the bacteria Sphingomonas sp. SKA58 and Sulfobacillus thermosulfidooxidans, is involved in the non-phosphorylative degradation pathway for L-rhamnose. It does not show any detectable activity with NADP+ or with other aldoses.",384,1.0,-0.031737514,-0.038961872,-0.06402519,-0.010756032,0.08160641,0.0969087,-0.093734525,0.04056136,0.0024487171,-0.006931014,0.0075236717,0.020904506,-0.054133844,0.09483965,-0.09012688,0.09042909,-0.08469998,0.006153814,0.02151884,-0.0009793697,0.085305214,0.01904833,-0.057495464,0.033284422,0.08823588,0.0059696073,0.04537898,-0.015568581,-0.08243468,-0.015251294,0.014019088,-0.022955524,0.049221437,-0.07977542,0.012769459,0.16413225,-0.0096721025,-0.060423154,0.050980512,0.02441398,-0.027126659,-0.01706356,-0.021863056,-0.027632108,-0.01731123,-0.019268362,-0.06390221,0.09813477,-0.0152232945,-0.0036634633,-0.054885995,-0.08032747,0.012633695,0.05652035,0.018677942,0.0045652813,-0.07740208,-0.006760581,-0.050025012,-0.045033615,-0.0036185167,-0.015678864,-0.03490499,0.059808835,-0.010954178,-0.0155379865,0.06686867,-0.034219876,-0.031923823,0.020169275,-0.06099722,-0.049279053,-0.016986286,-0.007690413,0.027035529,0.06626727,-0.030910242,-0.07498456,-0.034911223,-0.043187372,0.05546152,0.013735325,-0.0014382097,0.033913285,0.019796481,0.0071212896,0.024294784,0.008143265,0.022280473,-0.021081744,0.0048048417,-0.044667054,-0.0405099,-0.031112548,-0.087600835,0.0016320217,0.0061297286,0.03997914,-0.032589637,-0.048784472,-0.01853333,0.064148724,-0.0098266285,-0.11625985,-0.011775959,0.05813827,-0.053396776,0.094658315,0.011338872,0.0013915924,0.02832744,0.04473632,0.008180871,-0.039252855,-0.018804375,0.06100116,-0.013363122,-0.041897763,-0.17763421,0.006403009,-0.021300975,-0.037450723,-0.0019838153,-0.020079944,-0.0075131827,0.036849696,-0.065147154,2.3734114e-33,0.10496667,-0.030785337,-0.020922301,-0.05262922,0.028218465,-0.038921636,-0.07004444,0.031687185,0.010562395,-0.05070425,-0.016374035,-0.021439007,0.0011718946,-0.023122923,0.011439231,0.12420871,0.023512954,-0.026341682,0.020850422,0.0124467,-0.022840435,0.03329829,-0.0470245,-0.020938724,0.061689373,0.09519334,0.042761717,-0.014779932,-0.045613784,-0.01629265,0.074502885,-0.075845584,-0.17832808,0.009902188,0.036884744,0.0028885822,-0.06662969,-0.018698001,-0.027156759,-0.00018061264,0.04954308,0.026934048,0.0029418916,-0.012090047,0.006263709,-0.09842282,-0.018472953,0.060310446,0.024715675,0.13210031,0.08578938,-0.043997407,0.06664746,0.037911206,-0.009153465,-0.008616864,-0.0413008,0.009058112,0.022537528,0.036967557,0.073060654,0.022060456,0.007448304,0.015828023,-0.019498866,-0.038325742,-0.07788946,-0.07276707,0.0016911549,0.04242543,-0.053025402,-0.041312374,0.052820295,0.009403452,-0.0081595825,-0.08611219,0.0017646777,-0.027189506,0.022340754,0.057931345,0.021306682,-0.04807345,0.015131183,0.021702936,-0.054279007,0.0011627444,0.054276414,-0.031739905,-0.038274758,0.013530804,0.0025444312,-0.050199952,-0.06055942,0.043267973,-0.008504209,-4.4773404e-33,0.090215385,-0.07730782,0.10122092,-0.06564221,-0.051000144,0.05916143,0.043241292,0.030008083,-0.009923528,-0.08624448,0.04058725,0.035435922,-0.013587672,0.020821508,0.07153566,-0.009710934,0.02242696,-0.0032038623,-0.016508447,-0.012490395,-0.029120246,0.13060594,0.003201893,0.02087849,0.049864285,-0.025298506,-0.019045439,0.07310456,0.026637431,0.039508954,0.013543894,0.041144945,-0.050925072,-0.046829436,0.029255424,0.09006835,-0.030288393,0.04807939,0.011988047,0.066548124,0.058618788,0.043899298,-0.043835167,0.06383741,0.036703065,0.028068747,-0.123619094,-0.012236955,0.018668039,-0.051854484,0.040310692,0.0537388,-0.045068573,0.04499192,0.074191004,0.050520167,-0.09866551,0.026562247,-0.013340338,-0.051295176,-0.08063861,-0.056049,-0.050366763,0.04351441,0.054266192,0.10066773,0.012744694,0.0062496415,0.042194374,-0.0123566305,0.08670684,0.052467886,0.0061488342,0.00812634,-0.04502881,-0.09537039,-0.13849483,-0.018559895,-0.02031877,-0.010471116,0.05444549,-0.03018136,0.05108127,-0.041111868,0.034088,-0.04136403,-0.0038609614,0.029759096,-0.05072225,-0.057902787,0.099622324,-0.013702549,-0.06481202,0.017623907,0.046307985,-3.408087e-08,0.062566735,-0.011131628,0.064243965,-0.05847651,0.011626686,-0.022784408,0.05854475,0.01924085,0.008051609,0.045322154,-0.020121029,0.086296745,0.007132264,0.0075659687,0.08298824,-0.045550033,-0.050829083,0.06690843,-0.064942524,0.034875635,-0.03825723,-0.030860705,-0.09722245,0.04274417,0.048265476,-0.008183452,0.08979822,-0.030729068,0.024790023,-0.03431911,0.073162176,0.013585985,0.03604024,0.030389838,-0.043983847,-0.0076233423,-0.03583653,0.043024838,-0.044038817,0.048698865,-0.06764207,-0.040769838,-0.07968738,0.032583367,-0.037737526,-0.017428398,0.050059736,-0.011595953,-0.029427638,-0.0063285646,0.05360727,-0.025728151,-0.021128306,-0.101385206,-0.11143065,-0.04005613,0.07108371,0.008902806,-0.032412004,-0.10330185,0.047281925,-0.019550666,0.09870515,-0.039532084 +1.1.1.402,"The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism.",384,0.99999994,-0.018820018,-0.018832888,-0.10812506,0.12108877,-0.0007805561,0.021435324,0.020007301,0.060031626,0.0298566,0.0047052666,-0.030046534,-0.06663898,0.044392295,0.024082923,-0.06221828,0.08127348,-0.03493015,-0.04075196,-0.04384457,-0.0007146584,0.020990383,0.09150163,0.018058686,0.036826022,-0.065152615,-0.06908812,0.041737188,0.033753727,-0.06382683,-0.07326421,-0.06728525,-0.035519384,0.06920367,-0.0050502145,0.06313599,-0.005374832,0.055465233,-0.046572402,-0.009836596,-0.057777748,0.030109413,0.0070484257,0.01861067,0.022786304,-0.010756198,0.017558506,0.0296403,0.013314485,0.0721581,0.047616325,-0.059465904,-0.021474088,-0.014425203,0.065492935,-0.00088310335,-0.045647833,-0.03392829,-0.089369334,0.0072523165,-0.0076034158,0.040080424,0.018511938,0.025483428,0.02485535,0.006179618,-0.006357611,0.006425419,-0.09642731,-0.07517877,-0.028239584,-0.057548508,-0.17868163,-0.05362868,0.054827727,-0.006295003,0.040878795,0.08192632,-0.010604971,0.033206094,-0.02379163,-0.02667214,-0.0015018306,0.07726618,0.0538648,0.05452655,0.08771831,0.021992145,-0.061683275,0.016648753,0.021926152,0.007103666,-0.07951201,0.0102749625,-0.013085185,0.011562033,-0.037415717,0.044288512,-0.074855104,0.008935063,0.03208724,-0.09167922,-0.0063855196,0.029941527,-0.02937581,-0.041408077,-0.030903975,-0.018365955,0.04250273,0.027480057,-0.013911413,-0.011441655,0.043802883,-0.058478788,0.056150485,0.07146836,0.06872984,0.08654554,-0.05605957,-0.117763266,0.003649219,0.018447455,0.009790643,0.011083083,0.023005858,-0.014917845,-0.02598039,-0.026765883,1.1526165e-33,0.008026269,-0.08193459,-0.073363274,-0.014565545,0.066004254,0.0006193053,-0.079897664,0.04671921,0.016156007,0.0025933925,-0.07114621,-0.062959865,0.11678932,0.023182124,-0.006500593,-0.01339091,-0.018978903,-0.014370817,0.06690167,-0.038165532,0.02793536,0.043122754,-0.025572289,-0.061879355,-0.041945327,0.0331835,0.0054013953,0.009324344,0.048958186,-0.0063754553,0.030815288,-0.085876495,-0.06942373,-0.04202209,0.050303325,0.011779342,0.04739252,0.00085609686,-0.027566962,0.021615261,-0.027483346,0.02390586,-0.033775978,-0.0073825424,0.07009092,-0.1077688,-0.038739417,0.072435655,0.035746258,0.034749437,0.033728942,0.003784029,0.114902005,-0.0135011785,-0.066058785,0.05859384,-0.0007243267,-0.019364607,0.037403245,0.031618673,0.037862048,0.04552565,-0.0109836655,0.0004216401,0.0035641438,-0.046526264,0.019116253,-0.015212561,-0.030835086,0.05913375,-0.007505069,0.007876075,0.08237066,-0.030132625,-0.07148183,-0.02501633,-0.0753664,0.052724995,0.07027547,-0.00026453813,0.012295769,-0.047253255,0.012038582,0.049377825,-0.014810848,0.041897085,-0.060782146,-0.018586297,-0.056439873,-0.009397891,0.1409878,0.0101216715,-0.09710337,0.0015546485,0.029834831,-1.549334e-33,0.07192993,-0.06545299,-0.014211219,-0.010218348,-0.03499373,-0.0056138504,0.015245954,0.02159936,-0.038523797,-0.072687685,0.12306841,0.05555216,-0.0002289683,-0.000554088,0.001611584,-0.003764508,-0.015018516,0.023747476,0.008493417,-0.045861505,-0.048675068,-0.0002793405,-0.010626129,-0.13425876,-0.018484723,0.07611191,-0.059759032,0.06216117,-0.0017790954,-0.032180957,-0.019426439,-0.00637727,0.0021828723,-0.13780676,-0.042395603,0.040683605,-0.045995306,-0.0026161226,-0.005078981,-0.0606065,0.049230248,0.030196814,-0.09381984,0.049153086,0.064777,0.15652901,-0.079358004,0.053286616,0.08341841,0.050400198,0.0550442,0.04588524,0.07053168,0.0075299037,0.010461263,-0.0072915237,0.04935073,-0.09923532,-0.07583506,0.040204067,-0.034518175,0.06398658,0.09795357,0.028795326,0.053765193,0.044832993,-0.043434527,0.0004611787,0.04515843,-0.0075157858,0.048838988,0.06320585,-0.043148495,-0.004224499,-0.10520301,0.039999165,0.039105155,-0.035843603,0.007981059,0.007179351,0.020962738,-0.023536777,0.03895109,0.03192714,-0.07788888,-0.07613805,-0.019971507,0.046490327,0.08321136,0.00081088924,-0.010858981,-0.07321153,0.0051627387,0.033001967,0.031843904,-2.4916446e-08,-0.060828056,-0.05546852,-0.025665272,-0.0741839,0.04893115,0.041630957,-0.101642944,-0.0055402652,0.06341166,-0.031530004,-0.02663734,0.08955019,-0.06527926,0.03357031,0.013204683,0.030158442,0.0672203,-0.08157683,0.033541553,-0.042530894,-0.08708129,-0.04003768,-0.014341729,-0.04250118,0.07772021,-0.07396748,-0.06299622,0.0472114,-0.0074594324,-0.0028205558,-0.063192464,0.061886244,-0.008297863,0.012201485,-0.07334257,-0.003837775,-0.043681867,-0.05474005,-0.022692837,-0.015580656,0.05484846,0.029251523,-0.0010057201,-0.022454971,0.027298033,0.025855308,-0.04667509,-0.0021590525,0.035365377,-0.107289724,0.012245264,-0.015186611,0.0810331,0.02473097,-0.091361284,0.06813786,0.004825756,-0.0983111,0.066657476,0.054326978,0.026404982,0.008367697,0.11780145,0.02225097 +1.1.1.403,"The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of D-threitol.",384,0.99999994,-0.08970715,-0.05862316,-0.02055998,-0.0019632038,0.023460174,-0.039060734,-0.020619739,0.11235297,0.043388195,0.04324806,-0.080738604,0.015674233,0.009784535,0.041938536,-0.040787097,0.057818413,-0.015888495,0.02776456,-0.04557359,-0.01702272,0.061303955,0.065232955,-0.04409295,-0.065461576,0.057590332,0.032741133,0.014416172,0.01736721,-0.04508169,-0.067056336,-0.021869905,-0.044759504,0.07132529,-0.05250422,0.14560266,0.048820183,-0.04064465,-0.013488816,0.054636735,-0.09455171,0.031643115,0.006491593,-0.025073592,-0.014616368,-0.071835116,0.022374613,-0.053537685,0.07064296,0.02481271,0.037854288,-0.0937227,-0.043246362,-0.004547179,0.04707429,-0.013406382,0.020855187,0.02718629,-0.04949489,-0.019298462,-0.024547884,0.018106364,-0.016171997,0.026495486,0.026976312,0.03039992,-0.08880587,-0.005091857,-0.009941465,0.019752584,0.024630737,-0.09498417,-0.032032967,-0.01609166,0.122476466,0.056265652,-0.071353495,0.00667149,-0.05953307,0.056751862,0.013843451,-0.01047931,0.03200384,0.0007711274,0.015251424,-0.0008257573,-0.0030166097,0.07279265,-0.047965147,0.07156437,0.023195308,0.009160813,-0.046006873,-0.03732797,-0.07913334,-0.018057493,-0.012727036,-0.012685984,0.015922446,0.020136965,-0.026947197,0.009509114,-0.0044693197,-0.0057007084,-0.11453019,-0.07140473,-0.003195244,-0.07604185,0.083806336,0.04979574,-0.032356184,0.022335986,-0.010126369,0.053684752,0.046740964,-0.0035476666,0.037185226,0.09685398,-0.018910268,-0.04583682,-0.033872433,-0.009290089,-0.068311185,0.052085508,0.06055169,-0.072373345,0.030964287,-0.061561998,-2.7285364e-33,0.0204537,-0.07450156,-0.024618518,-0.0388991,0.019522866,-0.10637497,-0.060927626,0.015160715,-0.050148096,-0.020468073,-0.03729392,-0.112057775,0.0075262673,0.0030464616,-0.05871363,0.02985937,-0.013198251,0.039744247,0.011499576,0.031742822,0.05429902,0.055988763,0.0024102307,0.06536842,0.003049133,0.08575933,0.005787885,0.11073744,0.032831803,-0.0061794007,0.038923826,-0.04366618,-0.057306733,-0.016139733,0.046806756,0.03495224,-0.019048257,0.014612458,0.016876921,0.05130786,0.021726111,-0.025542766,-0.013506521,-0.03548412,0.060325775,-0.0546847,0.0014176865,0.059598643,-0.048188068,0.012662324,0.05751701,-0.10957562,0.06881156,-0.06747214,-0.05110473,0.009146059,0.00081775524,0.0038809213,0.04188173,0.032454424,-0.021065855,0.04111442,-0.051014625,0.098453596,-0.01411991,-0.05819187,-0.022459844,0.037103105,-0.022296526,0.083212174,-0.019706463,0.0415917,-0.027646953,-0.0030721428,0.06507508,-0.10365323,-0.05824048,0.05237187,0.030255776,-0.011854594,0.04212219,-0.007161713,-0.08602387,-0.011931796,-0.042349964,-0.02927701,-0.04232356,-0.08662296,-0.02177348,-0.0131708365,-0.0072127357,-0.0933621,-0.087917134,0.09045689,-0.03747278,-1.049554e-33,0.027871523,-0.074333645,0.111054644,0.046474755,-0.059634242,0.041344482,0.001536282,0.11163874,0.006374253,-0.028436225,0.052365616,-0.002902636,-0.034658886,-0.0046185553,-0.0030381805,0.0013944771,0.003038958,-0.07302572,-0.09563834,-0.011444541,-0.06261252,0.050248228,0.05653314,-0.07100647,0.007678668,0.021111004,-0.026889537,0.07095196,0.07229316,0.082164526,0.039746415,0.056047518,-0.00021902559,-0.06853765,-0.069942616,0.009663472,-0.045024708,-0.032255724,0.022046011,-0.01708154,0.014363532,0.051452756,0.050845537,0.059143662,-0.014188352,0.029283518,-0.0864469,-0.0015059396,-0.006227094,-0.06876865,0.013959932,-0.008050774,0.062438477,0.009913882,-0.018667607,0.063240446,0.03827075,0.0023406935,-0.051557165,-0.005268109,-0.065207675,-0.07661206,0.072106205,0.048507415,0.09718331,0.06724169,-0.011958759,0.12535888,0.024217356,-0.05670945,0.066071264,0.011244277,-0.02689791,-0.017180601,0.001948145,-0.061804153,-0.0811523,0.1100567,0.019240303,0.051930692,-0.063103154,-0.03606736,-0.040729534,-0.111336015,-0.011016218,-0.069196686,0.0049912995,0.11255343,-0.006856396,0.06444885,-0.08314156,0.032650325,-0.036534224,0.05169969,0.008492192,-2.4419855e-08,0.031810377,-0.059914216,-0.016654845,-0.0065275505,0.04101799,0.030342273,-0.059568465,0.04536845,0.07143671,0.07340544,-0.05419379,0.057883844,-0.03098587,-0.067840114,0.03437651,0.04546395,-0.054956075,-0.072932065,0.015675807,-0.00045224515,-0.02752119,-0.019647198,-0.03278046,0.06322411,0.028111542,-0.01811335,0.0520682,-0.0003615323,-0.05553555,-0.011816943,-0.054309882,0.074997686,-0.028881365,-0.02993849,-0.09839577,0.011960503,-0.04729812,-0.109535456,0.038247257,0.07985716,0.06987592,0.10428284,-0.058987748,0.010590793,-0.03127328,0.01956696,0.023578482,0.0073443986,-0.057869412,-0.030486254,-0.059163716,0.004259177,-0.093356594,0.0033846006,-0.07683006,0.04536061,0.023295606,-0.016352998,-0.02015589,-0.01835251,0.0846726,0.022410126,0.112067364,-0.0031484775 +1.1.2.9,"This periplasmic quinoprotein alcohol dehydrogenase, characterized from the bacterium Thauera butanivorans, is involved in butane degradation. It contains both pyrroloquinoline quinone (PQQ) and heme c cofactors. cf. EC 1.1.5.11, 1-butanol dehydrogenase (quinone).",384,0.99999994,-0.09767452,0.017438348,-0.12188317,-0.09392025,0.09803805,0.06111181,-0.048421334,0.034480557,0.0481792,-0.016169721,0.02917145,-0.07982601,-0.10381897,0.046511855,-0.07225071,0.077341616,-0.042764924,-0.040507615,0.019246694,-0.07813243,-0.007959884,0.039915208,-0.026658643,-0.018861778,0.019000597,0.011402571,-0.0040715053,0.093658276,-0.034747243,-0.06216244,-0.018962426,0.020725861,0.00071482576,-0.030685399,0.06787386,0.09885488,-0.041576304,-0.04418108,0.061520707,0.015415797,0.036435798,-0.0024849586,-0.03823807,0.035844047,0.008982639,0.032987807,-0.0073659737,0.13841605,-0.012330576,-0.019160254,-0.020809948,-0.0076256515,-0.029850556,0.027425751,0.08696874,0.03130734,-0.012148619,0.024712062,-0.085618995,0.036788125,0.008017564,0.033515047,-0.00023399979,0.019268086,-0.02236495,-0.034102235,0.061269682,-0.04319859,0.032240525,-0.059995197,-0.071054876,-0.10912441,0.003654002,-0.00040796297,-0.038638633,0.067141846,-0.0320215,-0.0125691015,0.023292264,-0.081684336,0.046515014,0.0184363,0.022932021,0.057960603,0.040686086,-0.06257182,-0.02956595,-0.08240739,0.04132725,-0.00087514747,0.02550074,0.010847988,-0.029217776,-0.10401433,0.02635488,0.12238343,0.07896628,-0.010976794,0.026495732,-0.0585141,0.0014817155,-0.005273998,-0.023947649,-0.07901253,-0.10736145,-0.00021826212,-0.010013359,0.030869063,0.083599366,-0.025672317,-0.061823085,0.0059977868,0.039500732,-0.0051694447,0.07343175,0.0018633537,0.13091324,0.0011942706,-0.01943802,-0.036368612,-0.055442728,0.019681245,0.040874075,0.052008215,0.0046775774,-0.026866999,-0.044149105,4.578753e-33,0.0472411,-0.014493985,-0.009911418,-0.0017558694,0.026268652,-0.011351446,-0.014435167,0.048964363,-0.11457983,-0.051922858,-0.005333872,-0.08145167,0.00074137456,-0.026616989,-0.05388724,-0.013295001,-0.05346696,-0.02210317,0.037437145,-0.024149613,-0.055422638,0.07824865,-0.054234155,0.01596461,0.074388966,0.08114754,0.07021117,0.0021571761,-0.0018581009,-0.045015402,0.010980453,-0.05815743,-0.094682515,-0.06902599,-0.031825732,-0.0076689045,-0.06904533,-0.006120247,-0.120253175,0.046501216,-0.031116879,0.030878484,0.006824489,-0.08995932,-0.04441449,-0.07439793,0.00394792,0.0600442,0.0016728143,0.010683403,0.029733116,-0.011190882,0.086536564,-0.06114403,-0.10447499,0.03593068,0.012609328,0.05476121,0.046810884,-0.0006054113,0.022853142,0.031372834,-0.06741902,-0.02931692,0.09858355,-0.061066136,-0.08445799,-0.05958366,0.08550113,0.067600615,-0.00064209994,-0.020777564,0.084161274,-0.040444113,0.0047219195,0.0073920093,-0.09784101,0.06064131,0.050567955,-0.0118834,-0.021182952,-0.027895896,0.08036282,-0.03761152,-0.02744439,0.0011564633,0.060055736,-0.0895932,-0.028122868,0.04088849,-0.0068160454,-0.05254793,-0.012103845,-0.00077897724,0.10513046,-3.7275183e-33,0.08208207,-0.081248306,0.00042200153,-0.02003584,0.015586858,0.07971895,0.020747406,-0.008290057,0.004897116,-0.046950884,0.078345455,-0.050618757,0.010344946,-0.05391735,0.06633141,0.057967503,-0.022033632,0.079963766,0.011362528,0.058328938,0.028670898,0.016013991,0.009016337,0.048542544,0.028199155,0.04539878,0.026324114,-0.010429189,0.038249068,0.058578443,0.02728169,0.008169514,-0.03460129,-0.03038395,-0.051853143,-0.026297871,-0.061417215,0.046191305,-0.033833224,-0.0075679733,0.03012165,0.013553969,-0.0037489622,0.042754803,-0.0050925515,0.04885667,-0.077043995,-0.013389186,-0.0027126707,-0.004763692,0.03416576,0.002842123,-0.052889496,0.055907164,0.040070776,0.041236304,0.0056969393,0.015109742,0.021742415,-0.03168462,-0.05495179,-0.03146714,-0.011759652,0.007971875,0.056303915,0.07527616,-0.02583304,0.056820396,0.03743416,-0.055264924,0.10792462,0.021416122,0.005118492,0.05397675,-0.08650131,-0.055437203,0.013676535,0.03417605,0.034774043,0.041754425,0.036639854,-0.06318283,-0.09004437,0.008401031,-0.016203512,-0.089606225,0.042792294,0.09341186,-0.010887183,0.03359749,0.04947474,0.019790266,-0.08184557,0.05610982,0.082752235,-3.6517864e-08,0.0067200633,-0.09244319,0.015992006,-0.0005212282,0.019524574,-0.0053983973,0.09684207,0.040786598,0.028768888,0.03178803,0.083451755,-0.026935715,0.01668837,-0.007835292,0.0582045,0.03866982,-0.004708587,-0.012789958,0.014782918,-0.011024966,-0.043060202,-0.00769019,-0.10604455,-0.016967658,-0.0108974865,-0.01934862,0.02133989,0.0078548165,0.04144083,-0.011479017,-0.047136545,0.05304909,0.038265947,-0.038967017,0.0006039201,0.018307641,0.01771748,-0.02253781,-0.03327494,0.022707077,-0.04414085,-0.0108730355,-0.07386503,-0.032140523,0.045641236,-0.010860054,-0.022039305,0.018548809,-0.038664516,0.023851678,0.07344907,-0.00055683847,0.08269439,-0.026556851,-0.13354301,0.035860267,0.04461399,-0.0320533,-0.042216737,-0.061650835,0.08750743,-0.035695728,0.22179186,-0.008641718 +1.1.5.11,"This periplasmic quinoprotein alcohol dehydrogenase, characterized from the bacterium Thauera butanivorans, is involved in butane degradation. It contains a tightly-bound pyrroloquinoline quinone (PQQ) cofactor. cf. EC 1.1.2.9, 1-butanol dehydrogenase (cytochrome c).",384,0.99999994,-0.10589667,0.027018411,-0.121263556,-0.090126365,0.084818564,0.04101511,-0.04337759,0.04309068,0.048038114,-0.022931604,0.033783853,-0.061448727,-0.0931243,0.046517607,-0.07157795,0.08446237,-0.03407892,-0.050780006,0.030780321,-0.06947841,-0.011300908,0.033956226,-0.021831658,-0.022404185,0.021083418,0.015026801,-0.01498608,0.08697357,-0.030037694,-0.05688838,-0.022658098,0.014755359,-0.0064622783,-0.025785496,0.060213435,0.10883114,-0.04861042,-0.03270657,0.05043483,0.022032553,0.028808817,0.016141418,-0.041371096,0.042029433,0.0053316634,0.011266293,-0.018248836,0.14522962,0.005455475,-0.022512218,-0.019200135,-0.0130581185,-0.023959948,0.024666712,0.08795185,0.03705808,-0.02009709,-0.001300536,-0.09397433,0.03462382,0.020314226,0.038704664,0.006114016,0.029595647,-0.008994818,-0.026887367,0.052648045,-0.046935968,0.048243247,-0.053597353,-0.07451295,-0.117461786,-0.001475263,-0.0014037605,-0.04022943,0.06190771,-0.036397427,-0.00938189,0.02219036,-0.08269883,0.050576314,0.009612173,0.010929663,0.06411839,0.053047203,-0.07118524,-0.002162802,-0.07982411,0.041288424,0.008440989,0.017831933,0.012836798,-0.032780383,-0.09159098,0.003771955,0.109635994,0.08579239,-0.005731042,0.010341169,-0.05434564,0.03005701,0.013295084,-0.024450462,-0.09130548,-0.10454982,-0.012736738,-0.017064748,0.03473282,0.078602575,-0.042494483,-0.06952574,-0.0007058657,0.029150937,-0.002710287,0.06747208,-0.012330915,0.12381396,0.0028542962,-0.022879412,-0.015146052,-0.057349652,0.032621104,0.013681249,0.05285014,0.010935451,-0.011365087,-0.05076173,3.7394815e-33,0.045889076,-0.0108616445,-0.016854916,0.017621081,0.030758547,-0.008428214,-0.012612644,0.049509097,-0.13689221,-0.03336714,-0.0038254778,-0.08068438,-0.00341558,-0.024196004,-0.04099913,-0.011278149,-0.053758,-0.01828178,0.05239819,-0.022952447,-0.055523608,0.070231035,-0.054314096,-0.0059310445,0.067350104,0.096934475,0.044247713,0.0061967904,0.003456758,-0.033248067,0.009337021,-0.07157083,-0.1085834,-0.065756746,-0.02096789,-0.023034377,-0.056834172,-0.021057444,-0.11349828,0.04418353,-0.041322377,0.029475264,0.013741285,-0.088463865,-0.030137656,-0.06100147,-0.0029191729,0.082889274,0.00034992455,0.006159048,0.03879151,-0.02061505,0.07980023,-0.05884944,-0.113827996,0.039748795,0.01334593,0.05185114,0.023339432,-0.0012999752,0.014373268,0.03512282,-0.080238566,-0.012411079,0.10407583,-0.058648124,-0.07617356,-0.0643098,0.07235455,0.07968139,-0.021472957,-0.018392727,0.08239371,-0.036287688,0.0051824492,0.012056738,-0.095642164,0.05429667,0.044378802,0.0043433732,-0.030025158,-0.026749369,0.074870594,-0.055561185,-0.02434127,-0.006187609,0.06049345,-0.09486509,-0.02201621,0.053333685,-0.020574572,-0.050577115,-0.0067575993,0.00084070524,0.09128406,-3.1694928e-33,0.08276004,-0.0949227,0.010953754,-0.016098265,0.025872674,0.07828341,0.009987285,0.012853947,0.01099533,-0.043156855,0.07507122,-0.055140574,0.02434189,-0.05056023,0.070764385,0.056868322,-0.023708679,0.08839054,0.0148998145,0.053663004,0.029770095,0.014728614,0.013814732,0.05909709,0.017853018,0.047381673,0.028724745,-0.013598698,0.03677448,0.055868644,0.011361197,0.014780915,-0.03920057,-0.041465763,-0.04648461,-0.009539299,-0.059204984,0.033674806,-0.022718525,0.004588941,0.03033321,0.03199056,-0.02301752,0.027162785,-0.0035222538,0.05146669,-0.06963838,-0.007520034,-0.00019305349,-0.008328089,0.039741892,-0.01059685,-0.035753448,0.0629829,0.04761292,0.049073867,-0.00866708,0.015474154,0.039790176,-0.020643162,-0.048766196,-0.0443359,-0.014160978,0.016731616,0.048148733,0.08206957,-0.019121278,0.04954609,0.026381532,-0.050881356,0.11007643,0.018734038,-0.0033969996,0.06493983,-0.086366974,-0.042596247,0.016743822,0.018653953,0.030545443,0.03219605,0.045311607,-0.06162211,-0.09490898,0.009258449,-0.0007124872,-0.10244164,0.03995626,0.10383228,-0.019967116,0.028283698,0.05585084,0.02056843,-0.092278585,0.04615284,0.07883991,-3.5445126e-08,0.011060113,-0.07061705,0.022538116,-0.0090832645,0.039543267,0.004530986,0.08940797,0.015710033,0.031860854,0.020815002,0.099606894,-0.009828156,0.01977304,-0.00044462236,0.055262893,0.04459832,0.0019578892,-0.021406772,0.020723412,-0.005859245,-0.04850232,-0.013427767,-0.10271222,-0.029286344,-0.0052824025,-0.033396356,0.033196013,0.01729065,0.04192659,-0.008119597,-0.054329034,0.050589304,0.030318318,-0.027111417,-0.014360083,0.013976988,0.0048797494,-0.035918433,-0.023745518,0.025473023,-0.053115148,-0.004604346,-0.06918322,-0.025157675,0.02416717,-0.020179383,-0.012167612,0.02924004,-0.050109427,0.0339271,0.06858625,-0.0046056085,0.08994113,-0.044827398,-0.13128497,0.028601704,0.047043018,-0.036915112,-0.06289192,-0.07132847,0.07391403,-0.027802624,0.21799724,-0.008295908 +1.2.1.98,"This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.",384,1.0,-0.07074125,-0.02937806,0.013146584,-0.0010927223,0.10061689,-0.01986061,-0.06558338,0.075355604,0.033229012,-0.04142953,-0.045709264,-0.07939553,0.03165188,-0.029556131,-0.037070353,0.04492799,-0.080312245,-0.027023051,0.05806828,0.0062797857,0.07207531,0.068815455,0.0026148567,-0.06501246,0.0020620401,0.09159172,0.044529367,-0.02506091,0.022301195,-0.047438666,0.048428606,0.055281408,-0.014900225,-0.1029781,0.03104048,0.10863764,-0.05955265,-0.012695497,0.058212698,-0.0031805448,-0.023297353,-0.02978576,0.03979214,-0.0716628,-0.037888438,-0.032126006,0.028499706,-0.024490416,0.033847816,-0.0923175,0.051413104,0.018057546,-0.03533074,0.072208114,0.06272953,-0.061037242,-0.034107115,-0.05460577,-0.07094017,-0.029935557,0.036887746,0.09095854,-0.019554628,0.02279984,0.0032666903,-0.028127156,-0.02829062,-0.024326093,0.040522333,-0.07107584,-0.13157861,-0.04113137,-0.009057733,-0.011016952,-0.0035821772,0.03866057,0.057923205,-0.022614963,-0.0040538763,-0.028800052,0.02872474,-0.010395777,0.09934277,-0.0047439113,0.034865443,-0.05112425,0.036638957,-0.04254061,0.096280135,0.0044239205,-2.6122112e-05,0.015578426,0.0028980675,-0.023402875,-0.019739594,-0.0019232624,0.021653874,-0.00518275,-0.0031457562,0.004098317,-0.03959581,0.0684319,-0.124845706,-0.074211806,0.06627396,-0.00634387,0.05545404,0.15397792,0.096243165,-0.0145264175,0.021203378,-0.0040542325,0.031279087,-0.018983958,-0.05334104,0.037414048,0.053599253,-0.07164079,-0.09467463,-0.017552787,-0.040909927,-0.0069622714,-0.0013030263,-0.00629284,-0.04065695,0.034810066,-0.026399191,3.0088743e-34,0.008441326,-0.048338734,-0.04990586,-0.08146326,0.014188623,-0.033483032,-0.041669745,0.022873746,0.010686361,-0.09339562,-0.0765291,-0.0770729,-0.07672853,0.06213962,-0.0333021,-0.03492345,-0.013583441,-0.016505565,0.07568224,-0.06654726,-0.012306997,-0.007983427,-0.04070193,7.693024e-05,0.07073724,0.021575619,0.087839976,0.029289283,-0.02129127,-0.009400082,-0.010376589,-0.05336975,-0.115963764,-0.051008232,0.09119939,0.042574853,0.01748099,0.023243103,-0.05412373,0.066998996,0.0197912,0.021135926,0.00395698,-0.04357288,0.05726638,-0.020880675,-0.0005974798,0.10255507,0.02629011,0.032470305,0.010595262,-0.0026877203,-0.029305378,0.011213147,-0.089351594,0.05631533,-0.0112871565,-0.03662149,-0.0005873659,0.035274483,-0.027850715,0.10434221,-0.038783167,0.03301232,0.0047122096,-0.0026350783,0.028301818,0.0023375426,0.046123866,0.082428224,-0.10295657,0.042776864,0.08971588,0.03169841,0.019351505,-0.048529997,-0.061834037,0.0016327498,0.1055041,0.011787015,0.040435348,-0.09736188,0.044382785,-0.009258518,-0.019043054,-0.040860362,-0.026164602,-0.051431105,-0.015037601,0.040716518,0.088880785,-0.01078406,-0.028608002,-0.034227427,-0.022935152,-1.7984351e-33,0.08000587,-0.047322206,0.033008736,-0.07558912,-0.01546318,-0.009985321,0.021975981,0.008664129,-0.015953882,-0.005359336,0.02452724,0.0432093,0.09785384,-0.11978793,-0.00074219605,0.0005387484,-0.010467907,0.044924065,-0.042445585,-0.058574293,0.021693949,0.03253084,0.019832801,-0.028409516,-0.02537383,0.008557811,0.041355595,0.025444416,-0.022636246,0.025823355,0.04835643,0.112734415,0.03134607,-0.026589105,-0.06754814,0.07110391,-0.0009486703,-0.044746242,-0.016298534,0.004828897,0.087373324,-0.020828431,-0.007176836,-0.004470208,0.015587312,0.009720368,-0.066814125,-0.077952266,0.10404567,-0.037868697,0.06589159,-0.024916567,-0.014564433,0.0089492295,-0.033771418,0.028419241,0.016160678,0.0046995655,-0.008997542,-0.022503583,0.02956022,0.017967423,0.057246305,-0.011557399,0.021333184,0.0033950265,-0.02582316,0.03405699,0.029652052,0.007730918,0.09885061,1.4374875e-05,0.040261913,-0.024644464,-0.022212908,-0.010874584,-0.060734697,0.04561772,0.008887933,0.011392115,0.03469969,0.0063059316,-0.0046864287,-0.06685755,-0.035411768,-0.06964747,-0.0075056483,0.064534925,-0.008539598,0.049939986,-0.050888747,-0.04003751,-0.14119521,0.08717175,0.027729396,-3.5127485e-08,-0.027391238,-0.08182705,-0.055614177,0.059614133,0.0047357823,0.08152121,0.020694733,0.022779517,0.03980886,-0.011829927,-0.033053078,0.100335404,-0.062157135,-0.007964007,0.043914508,0.017387697,-0.047295466,-0.06490187,-0.030951384,-0.040891256,-0.016608953,-0.008931669,-0.010253271,0.06584367,0.08018428,-0.021027433,0.04469916,0.07026335,0.004681014,-0.024417207,0.005655486,0.08632255,-0.084763356,-0.014560946,-0.020908099,0.011196996,0.018855073,-0.038060762,-0.018861137,0.13401541,-0.025015732,0.05125988,-0.08361251,-0.02621984,-0.00017149784,0.0629086,-0.062496796,0.1306309,-0.050527547,-0.07083165,0.078891724,-0.039819546,-0.019868996,0.029190328,-0.06925077,0.050054763,-0.047950488,-0.04073203,-0.04873214,-0.077237956,0.0010808598,-0.015688356,0.20541152,-0.028849453 +1.2.3.15,"The enzyme, originally characterized from the white rot fungus Phanerochaete chrysosporium, utilizes a free radical-coupled copper complex for catalysis.",384,1.0,-0.03201092,0.029160867,-0.11957854,0.03885368,0.122932635,-0.016898898,-0.0652439,-0.025321532,0.037600733,-0.025798243,0.04545232,-0.01151299,-0.038810395,-0.0047392175,-0.07889097,0.0005103944,-0.072159834,0.04328934,-0.009389339,0.011249835,0.03060253,-0.03107408,-0.0061421636,0.060883533,-0.017894795,0.05346516,0.06458061,-0.035325155,-0.028401002,-0.062352307,0.008925105,0.011805381,0.0109112365,0.020824447,-0.041044958,0.046735622,-0.05952837,-0.0039195055,-0.016583951,-0.0110391565,0.0037254337,0.007599669,0.08416306,0.010988018,-0.035019774,-0.047771342,0.0063845515,0.054908775,0.04506977,-0.06577752,-0.04216276,-0.0039341585,-0.033393055,0.05586401,0.04227783,0.0710197,-0.052806,-0.04723233,0.015852123,-0.043963343,0.07280174,0.0052170656,-0.0026664692,0.031103687,-0.05331127,-0.02218125,-0.01661017,-0.049336147,0.026455581,-0.05912928,-0.11792537,0.0053907046,-0.057276167,-0.021828044,0.06404855,0.11038257,0.11363117,-0.0654431,0.036961235,0.013092617,0.01899538,0.06378253,0.037600484,-0.018688755,0.07019724,0.073826164,0.039946757,0.007702384,0.056571394,-0.0272609,0.09946212,0.07380688,-0.034547206,-0.03588517,-0.08617382,0.08577484,0.0751406,0.090605214,-0.002852371,-0.042874575,0.055015348,0.053529207,0.0050326395,-0.13281016,-0.058854267,-0.03154064,-0.0074973693,0.11370968,0.058460493,0.004611121,0.021304518,0.007500285,0.03618264,-0.037061572,0.01772537,0.048603915,-0.00474253,-0.065379426,-0.0741778,0.012155026,0.038437545,-0.01062597,-0.08926005,-0.011647161,-0.036889013,0.020481026,-0.056703813,1.6652995e-33,0.0111839045,0.08956376,-0.06569366,-0.07752897,0.082018614,-0.070035234,-0.081570454,-0.016992679,-0.071022384,0.0036369492,-0.0111545725,0.019625625,-0.052176047,-0.016197246,-0.043397173,-0.018396093,0.0046782508,0.016492026,0.044598717,0.024871675,0.04139969,0.097876914,-0.036527675,0.020821676,0.06474833,0.034612764,-0.005242063,-0.011081586,0.016153086,-0.027432693,0.047748912,-0.026487172,-0.06373056,0.023384169,0.035757907,-0.013992425,-0.0039858026,-0.06909325,-0.022948777,0.036468677,-0.04011353,0.01220632,-0.00691687,0.071703054,0.030594727,-0.11186529,-0.043493986,0.13583736,0.03192518,0.019952642,0.018866321,0.0041813273,0.101678416,0.016387336,-0.031133259,-0.011827728,-0.027086288,-0.047499735,0.040944554,-0.010327418,-0.03078141,0.063651994,-0.08280169,0.055515505,-0.015871948,-0.057363123,0.014068775,0.06413852,0.023101857,0.047387373,-0.032155413,-0.018081848,-0.042655904,-0.003958009,0.027262375,-0.021285199,-0.00725357,-0.10358538,0.011494001,0.052040536,-0.009754215,-0.031139817,0.041048765,-0.0007643451,-0.032497253,-0.010522373,-0.089680485,0.067136034,-0.021873595,-0.005639269,-0.02700312,0.015926024,-0.0019929158,-0.010138571,0.02109506,-1.6444747e-33,0.063974,-0.0898259,-0.02078639,-0.029466119,-0.02800304,0.041750174,-0.017140346,-0.084910855,0.018236907,-0.13557087,0.031962164,-0.030795386,-0.006545134,-0.012202955,0.0777732,0.020403914,0.003314286,0.14457847,-0.021202156,0.027928086,-0.048181202,0.08517414,-0.061880272,-0.004743806,0.058457162,-0.008313953,0.042105697,0.06882249,0.027198223,0.026592154,-0.0106819905,-0.01832205,0.056710545,0.0074656475,-0.053859416,0.060848765,-0.028702445,-0.034272555,0.049405985,0.04964916,0.059798047,-0.02702274,-0.07374927,0.047503676,-0.028845292,0.059919782,-0.1156875,0.016709175,0.028370151,0.031086918,0.07470821,0.068357505,0.00074468314,-0.041549537,0.04384082,0.0064598266,0.0023249357,-0.035871,-0.0014977381,-0.031008214,-0.05570151,-0.01133137,-0.043313064,0.029356776,0.05131714,0.067429595,-0.004924484,0.01809248,-0.02467637,-0.055205762,0.057612218,0.09088957,-0.00041415356,0.029878601,-0.023168681,-0.0058809225,0.013898221,0.062613815,0.00028314683,0.060858615,0.040426414,-0.0038571353,0.13837995,-0.14479207,-0.018012065,-0.031758115,-0.03041831,0.07703201,-0.051328767,0.010803786,0.0017663764,-0.028591422,0.021773305,0.04012277,0.09424418,-2.5983468e-08,0.0012260256,-0.011909635,0.033242464,-0.12640491,0.022582935,0.0636838,0.07591002,-0.05879554,-0.038980417,0.0029771228,-0.03348676,0.02967681,0.059105597,0.034448184,0.064883925,-0.0049092155,0.0036163335,-0.06647341,-0.03457293,0.020331647,-0.049689006,-0.0011828811,-0.14091301,0.019926531,-0.022864256,-0.01063612,0.07189203,0.023872063,-0.091195285,0.06217709,-0.037559483,0.011521116,-0.02766206,-0.00056943164,-0.049407165,0.018701084,-0.009726334,-0.043455567,-0.032849215,0.023861872,-0.03161999,-0.04107415,-0.034148276,-0.03903753,-0.11760742,-0.045348212,-0.023023866,0.033053663,0.044770405,-0.011422644,0.06455445,-0.038936377,-0.027022924,-0.078326166,-0.038104877,0.009205975,0.11063793,-0.019223643,-0.040327836,-0.07696081,0.043335963,-0.02357794,0.15573072,-0.044152834 +1.3.3.15,"Contains FAD. The enzyme, present in Gram-positive bacteria, participates in heme biosynthesis. It can also catalyse the reaction of EC 1.3.3.4, protoporphyrinogen oxidase, at a lower level.",384,1.0,-0.0922521,-0.019349981,-0.05674113,-0.01870111,0.1392484,0.048449796,-0.039919365,0.0787972,0.041670706,0.01925402,-0.016349673,-0.07415651,-0.092197284,0.026250169,0.0022988182,0.008827245,-0.08578522,0.047962867,-0.06588168,-0.06437626,0.052374817,0.067038454,0.015152291,-0.006955438,0.021544173,-0.02656412,0.09490829,-0.049972635,0.02312742,-0.046590906,0.06330002,-0.019778514,0.10091869,-0.058160573,0.05807636,0.07372518,0.06949755,-0.11721315,0.08567546,-0.020263443,0.045706782,-0.027933102,-0.040580496,-0.02988958,0.03384202,0.035555556,0.0903058,0.0005067986,-0.050421577,-0.046913806,0.005202003,-0.020059643,-0.07409473,0.03015558,-0.031871244,0.015975028,0.044704292,-0.043692015,0.008775167,-0.03768553,0.0038200058,-0.02625558,-0.011188726,-0.009326394,-0.00834759,-0.08775622,0.016597036,-0.0306972,-0.009491976,-0.051397346,-0.014033841,-0.07617939,-0.03795941,0.057398714,-0.033851583,0.06459251,0.00334169,-0.06881979,0.055645406,-0.0053963065,0.050848275,-0.0016184327,0.05723062,0.13699564,0.038562078,-0.03522472,0.01619423,-0.024726676,-0.041705463,0.039303113,-0.010615644,-0.042826734,0.013099449,-0.03789412,-0.07280556,0.08302828,0.07330868,0.018421022,0.062279366,-0.024984729,-0.032769255,0.08318426,0.010337829,-0.032916922,-0.06622446,-0.020133184,-0.021589797,0.13097009,0.062718906,-0.00198086,0.023823207,-0.05340561,0.041044302,-0.025203213,-0.07295639,0.023975955,0.013368146,-0.09701173,-0.039377704,-0.0088580875,-0.0023518382,0.00060193136,0.06170079,0.09625159,0.004921404,-0.010570851,-0.103073865,6.3479726e-34,0.050262354,0.0014315014,-0.045794975,-0.05221924,-0.037993938,0.00040432168,-0.13266432,-0.01706875,0.021276545,-0.02841993,-0.058991473,-0.0674569,0.038983736,-0.008566906,-0.021682559,-0.011134892,-0.066348344,-0.03633665,0.021372179,0.0077013965,-0.004413683,-0.010497465,-0.026195437,-0.006288113,0.0412341,-0.008584739,-0.0039326963,0.0039520124,0.038854692,0.0016738734,-0.003329471,-0.074352935,-0.052006166,0.02266537,-0.005591599,0.011904673,-0.08302445,-0.021144882,-0.060776312,0.043925907,0.019918872,0.07157695,-0.017750729,-0.036641695,0.0973172,-0.07607249,-0.027949242,0.07078495,0.06521393,0.121431686,0.023926118,-0.0098219635,0.11337528,0.001178796,-0.0074746576,-0.0014581847,-0.059246175,-0.006053569,0.06791202,0.024683569,0.034919154,0.07969253,-0.029647801,0.063895255,0.0056206286,0.017070325,-0.0013343862,-0.02697323,0.008222038,0.088704504,-0.0527891,-0.007492612,0.045408607,-0.017928304,0.018640343,-0.055886984,-0.024653899,0.018215727,0.038491126,-0.024664944,0.0231809,-0.058155794,0.023381896,-0.02249468,-0.031822484,0.010019882,-0.05894138,-0.026986428,-0.029414037,0.009199147,0.081928246,-0.12263021,-0.07173285,0.041626513,0.00634376,-1.0895609e-33,0.105699584,-0.061251294,-0.0013211868,-0.1164287,-0.0440078,0.08235975,-0.011516367,-0.038785234,0.0041972343,0.018246548,0.055264786,-0.0034805576,-0.049577367,-0.017925052,0.010879353,-0.011967176,-0.0036631688,0.058433767,0.018942505,0.046762627,-0.003096594,0.05738139,-0.0029984643,0.035480395,0.07858788,0.016361149,-0.060087614,0.038649958,0.027734667,0.044209767,0.04030994,0.027466321,-0.04052483,-0.02472021,-0.051403414,-0.031968333,0.015904447,0.042076334,0.030097999,-0.007985786,0.040424716,-0.008375723,0.061381027,0.08877126,0.063116714,0.07229323,-0.106537245,0.042126145,0.019016689,-0.03038964,-0.008717921,0.02163025,-0.010513995,-0.014323925,0.053326312,-0.009225201,0.0142539125,0.044835463,-0.07426864,-0.038617972,-0.044791613,-0.025117243,0.07264572,-0.005307458,0.07140947,0.036082488,-0.07764587,0.11866607,0.049184456,0.030789314,0.08767108,0.04878177,-0.03851932,-0.025715677,0.022534724,-0.0052909376,-0.030107833,-0.011034843,0.081018955,0.006724245,-0.022244144,0.04780081,-0.03397688,-0.07123627,-0.07348571,-0.02713607,-0.035359457,0.104962006,-0.0075442116,0.0009883555,-0.05363073,0.006742795,0.0060003335,0.0039945967,0.069750436,-3.6900335e-08,-0.01990636,-0.06306775,0.006998593,-0.04037413,0.027215116,0.06836149,-0.0110083595,0.009908255,0.047278635,0.0041908887,-0.03342067,0.08646147,-0.014772212,-0.06751866,0.060116246,-0.023115112,-0.05757184,0.017513523,-0.06452964,-0.009569401,-0.013274232,0.05457568,-0.083532296,0.07917104,0.01246022,-0.08820321,0.0392665,-0.03834374,-0.017822554,-0.014218453,0.020555366,0.02975604,-0.028246278,-0.026176456,-0.0347408,-0.0015957622,0.053947967,-0.052421555,-0.056593094,-0.011991205,0.01999417,-0.018374875,-0.10504935,-0.04578641,0.0046303,0.06382522,0.0423202,-0.008357243,-0.063050024,-0.06097515,0.033440016,-0.049537323,-0.0148256505,-0.016319374,-0.16570376,0.004569574,-0.017795911,-0.0700364,-0.020942125,-0.024697313,0.069583684,0.028434953,0.21648844,0.009292085 +1.3.7.13,"The enzyme, found in many phototrophic bacteria, land plants, and some green and red algae, is involved in the production of monovinyl versions of (bacterio)chlorophyll pigments from their divinyl precursors. Binds two [4Fe-4S] clusters and an FAD cofactor. It can also act on 3,8-divinyl chlorophyllide a, 3,8-divinyl chlorophyll a, and chlorophyll c2. cf. EC 1.3.1.75, 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH).",384,1.0,-0.09116684,-0.010081959,-0.08706207,-0.04051272,0.076124914,0.06849412,-0.02439698,0.05320075,0.079346724,-0.017545931,0.042103782,-0.085042454,-0.032000232,0.045739524,-0.03753996,0.05929845,-0.145954,0.023497228,-0.061182123,-0.03762786,-0.032677203,0.016174108,-0.06216842,-0.04392419,0.040069174,0.012826703,0.012118447,-0.024324713,0.011277201,-0.08466994,-0.022502463,0.04827798,0.04614764,-0.019157853,0.07768447,0.08935433,0.037327122,-0.104655035,0.025018116,0.041521728,-0.0053352253,0.03559831,-0.0145536335,-0.01886989,-0.04722046,0.009129163,-0.003258676,0.085906334,0.034140576,-0.075694725,-0.018872378,-0.007185451,-0.028211718,0.018941669,0.019429741,0.0010303945,0.04995704,-0.05269913,0.032890465,0.0070841312,0.06356255,-0.055013195,0.0064545954,0.023199443,-0.020007206,-0.01481723,-0.0019816025,-0.08628018,0.05393579,-0.072237186,-0.08286451,-0.0345537,0.0050862003,0.017173544,0.0002921755,0.054949228,0.029037433,-0.027174724,0.017524382,-0.032151595,0.06334117,0.046708595,0.014622486,0.057758898,0.09595187,0.0387475,-0.01405452,-0.019525336,0.029424591,-0.020175364,-0.03326316,-0.01117723,-0.05646525,-0.05812217,-0.13098164,0.09896131,-0.001476888,-0.09791709,0.0790767,-0.03394938,-0.0013389506,0.0019706571,-0.018079666,-0.077919476,-0.04916883,-0.026465112,-0.015966276,0.10890416,-0.015619583,0.0034435396,0.032126635,0.01619436,0.0031514007,-0.016252168,-0.036266327,0.04129072,0.060091637,-0.06741967,-0.08471707,-0.024958124,-0.024198445,-0.03218328,-0.001909581,0.028131505,-0.030985931,0.009165858,-0.17472492,2.2975421e-33,0.10733289,0.026333364,0.003005574,-0.008772903,0.06702524,-0.04395933,-0.08100848,0.00054283236,-0.06087819,-0.09183209,-0.0058154715,-0.07186999,0.034011185,-0.034561276,-0.019681418,-0.033182025,0.0065842345,-0.00024166207,-0.06040084,-0.045129705,0.00084136275,0.09964837,-0.036053784,0.08303316,0.030033126,0.05552641,-0.040178765,-0.0005120579,0.123786084,-0.029939508,0.029947769,-0.061438568,-0.05864755,0.016862892,0.07534363,0.012328553,-0.054766495,-0.06169848,-0.05312348,0.07647871,-0.04679578,0.081504114,-0.03185942,-0.012451841,0.08968647,-0.05136039,-0.060903423,0.03330367,0.058094412,0.08158038,-0.032318883,0.02888687,0.07588496,-0.023547161,-0.06605287,0.037795782,-0.017908031,-0.044599522,0.026591552,0.041652463,-0.0062526017,0.059365403,-0.06812829,0.047311004,0.022817282,0.05107942,-0.0022456062,-0.012681936,0.06158702,0.081377104,-0.040608626,-0.014546007,0.016868643,0.009292829,0.09717193,-0.030217793,-0.012354589,-0.038604107,-0.0075869313,0.011253162,0.0068600946,0.01600355,0.017355265,-0.10992894,-0.10737971,-0.004455923,-0.009940267,-0.032609954,-0.005182764,-0.019552602,0.096101716,-0.03523624,0.010081204,-0.034292094,-0.04127174,-3.811534e-33,0.09659321,-0.06651874,0.07113063,-0.079496846,-0.025065688,0.026009468,-0.017615506,-0.054931097,-0.0049153473,0.035097234,0.08540323,0.05925652,-0.023496654,0.034451243,-0.0077910516,-0.0022870372,0.0886807,0.111399606,-0.006188059,0.022835733,-0.026535686,0.031730045,0.11004953,0.050106686,0.03571398,-0.009889995,0.0016959026,0.012546588,-0.005433275,-0.016548164,-0.018363839,-0.0394129,-0.01803256,-0.007904358,-0.020793224,-0.048216745,-0.065198556,-0.0072118994,-0.0016975392,0.027253712,0.012658029,-0.04474892,-0.02824045,0.05014563,-0.0068359333,0.005358603,-0.056051012,0.07986087,0.011472357,-0.042538676,-0.011151458,0.029377082,-0.036269143,-0.017350843,0.013061962,0.03886283,0.08002869,0.041256174,0.0037599986,0.05421481,0.010595115,-0.12620303,0.05698119,0.056403648,0.06960141,0.082598045,0.023053616,0.09494803,0.03952005,-0.014085104,0.026462933,0.09084878,0.060283687,0.04245808,-0.05806273,-0.071619816,-0.03811851,-0.055859998,-0.035025336,0.0025175828,-0.044709776,-0.025167832,-0.017610721,-0.028006647,-0.021922167,-0.07589456,0.018860307,0.04559419,0.004787898,-7.855186e-05,-0.018027231,0.05085859,0.03825635,0.06365079,0.083559476,-4.464362e-08,0.02735598,-0.014204748,0.030158916,-0.07339715,0.017153133,0.005425022,-0.005130146,-0.039062183,0.06270955,0.0075943936,-0.027885878,0.08913611,0.015679134,-0.034038205,0.05698546,0.015453098,-0.04428455,-0.066677056,-0.0057367985,0.015473636,-0.051906046,-0.009075539,-0.114729755,0.07722492,-0.023167726,-0.04147994,0.021010784,0.04983596,0.014222753,-0.035985842,0.03640264,0.04764718,-0.04390105,-0.019619018,-0.065244734,-0.029802147,-0.10416711,-0.029070066,-0.1044326,0.09288163,0.044640988,0.007991212,-0.042910818,0.040487066,-0.040353134,0.06524194,0.022891834,-0.0011295063,-0.01924463,0.04053394,0.030694801,-0.004054153,0.024238616,-0.016469952,-0.13421111,-0.037322108,-0.0034996078,-0.039204195,-0.04703716,-0.009693608,-0.0035719196,-0.033682175,0.14666048,0.06638447 +1.3.7.14,"The enzyme, found only in bacteriochlorophyll b-producing bacteria, catalyses the introduction of a C-8 ethylidene group. The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of nitrogenase. It is very similar to EC 1.3.7.15, chlorophyllide a reductase, and is composed of three subunits. Two of them form the catalytic component, while the third one functions as an ATP-dependent reductase component that catalyses the electron transfer from ferredoxin to the catalytic component.",384,1.0,-0.06372372,0.009445884,-0.0847433,0.006589731,0.10882548,0.059606414,-0.031572394,0.012433544,0.042722236,-0.10485807,-0.036932617,-0.102439456,-0.0068881433,0.024591563,-0.061179496,-0.0034121112,-0.11254434,-0.00029811222,-0.025157128,-0.08715167,0.00902646,-0.015128294,-0.0107729165,-0.045423135,-0.035285484,0.037732664,0.06391624,-0.03753662,-0.050516393,-0.10884515,-0.035715904,-0.00020625946,0.07959295,-0.030526327,0.055251736,0.111574896,0.016575214,-0.096561365,0.044113956,0.007586005,-0.04756611,0.056791175,0.0030516842,-0.02704198,-0.039770298,0.0020541074,0.059033766,0.021212153,0.050360367,-0.06614753,0.015806058,-0.019826593,-0.02813453,0.061194364,0.06659999,-0.04152357,-0.031305134,-0.08897631,0.02048445,0.034952257,0.104887016,-0.0075686444,0.041333754,0.037469234,0.004501502,-0.052097514,0.03639496,-0.09041847,-0.0049141855,-0.08395498,-0.045724314,-0.048588976,-0.027117249,0.042207375,-0.0053156903,0.010424375,0.07639229,-0.0053696916,0.030407885,0.009053601,-0.008131954,0.0423404,0.007101834,0.06373687,0.071671985,-0.01458265,-0.045078296,-0.03875513,0.023019344,0.005934424,0.007095531,0.014876643,-0.020187246,-0.03749932,-0.08158431,0.07397797,-0.046513245,-0.0041472064,0.026054423,-0.0002571472,-0.02228869,0.081629895,-0.04769085,-0.04553209,-0.032796666,-0.0013245817,0.01576847,0.14659938,0.025888117,-0.00084347406,0.027510257,0.029556897,0.04156312,-0.015267607,-0.01150327,0.04119722,0.030303713,-0.04398838,-0.056494273,0.03638057,0.02918243,-0.019543419,-0.01680968,0.063476644,-0.0630473,0.033054877,-0.17588797,2.1074525e-33,0.07466504,0.04555036,0.002125013,-0.0072977045,0.019072847,-0.028813718,-0.057911325,0.050759092,-0.01235974,-0.064791255,-0.05808667,-0.066600546,0.07563869,-0.09728737,-0.04868099,-0.06919131,-0.031605605,0.011761865,0.009448086,-0.025306245,0.0130415065,0.03516779,0.0008301667,0.031005763,0.07539509,0.060139768,-0.0015254173,-0.028600246,0.09333715,-0.015805384,-0.015618206,-0.046181597,-0.12257434,-0.0084692165,0.030927962,-0.07124277,-0.016791686,-0.008632253,0.005318159,0.069082946,-0.05213825,0.05927379,-0.02088248,-0.051222727,0.077651955,-0.03636375,-0.08441686,0.053166557,0.08934705,0.101745896,0.031393204,-0.031455677,0.09856949,-0.072476916,-0.05967856,0.06423204,-0.0037384247,0.008783539,0.022745082,0.067159414,0.065221734,0.083518155,-0.042239103,-0.028189208,-0.008195272,0.027444158,-0.008113561,-0.02589827,0.042802785,0.06393822,-0.08504826,0.03329346,0.08930209,0.013797895,0.09500292,-0.069149986,-0.087459505,-0.08713123,0.05283955,0.016282065,0.03360187,0.004602284,0.06337615,-0.0790983,-0.030249773,-0.05704275,-0.05999407,-0.043305106,0.009869452,-0.0077127735,0.081480764,-0.04800754,-0.07800164,-0.0007697532,-0.064432524,-2.920715e-33,0.06944901,-0.12716143,0.05894034,-0.1286492,-0.049004048,0.008319258,-0.011730941,-0.057793546,-0.026347011,0.04976681,0.090671256,0.0029660019,0.03005244,-0.0053292746,0.037393127,0.02254382,-0.008695592,0.08852052,0.026402315,0.020049745,-0.001992889,0.019280951,0.03100036,0.029506778,0.038423367,0.009471,-0.041590113,0.038538314,0.13406673,-0.03735836,-0.015156175,-0.06148455,-0.044022057,-0.0049393014,-0.01151126,0.027746089,-0.026631474,0.009125298,0.05487713,0.008239613,0.014317316,0.016407695,-0.017494872,0.054584384,0.013377466,0.051556863,-0.031182447,0.039621223,0.014027052,-0.012702422,0.02323332,-0.008149545,-0.048019223,-0.030858813,-0.035455238,0.02189121,0.07471312,0.016728008,0.010176836,0.037031725,-0.0016554256,-0.094262145,0.0628214,0.07128074,0.020018267,0.07775191,-0.047392085,0.08894127,0.024864702,0.0025323958,0.027981527,-0.011499415,0.02880408,0.0036899438,-0.03536079,-0.03597814,0.036920387,-0.060971566,-0.03793206,0.008984476,-0.055521302,0.02352766,9.677026e-05,-0.057444215,-0.008394626,-0.053338278,0.04467097,0.036241453,0.034721088,0.009278925,-0.016685355,0.01850474,0.015803836,0.04699958,0.0516036,-4.0055095e-08,-0.009074522,-0.068045065,0.0379887,-0.045243498,0.06075022,0.035976507,-0.030142393,-0.08747935,0.055696703,-0.04846259,0.0055632005,0.05884307,0.01935017,-0.037630975,0.038255148,0.030096715,-0.04013315,-0.026656142,0.043451343,0.067305215,-0.0029872223,-0.002903801,-0.13548546,0.06965574,0.014175645,-0.050428186,-0.03144843,0.044359986,-0.0029638503,-0.053054284,-0.019816687,0.06634871,-0.014207777,-0.002231055,-0.067164935,-0.041505724,-0.057610396,-0.017767394,-0.092056,0.037112474,0.050624996,-0.008039095,-0.036777318,0.006737347,-0.0018948099,0.054469302,-0.014081233,0.0019834677,0.025818713,0.027502913,0.047906015,-0.043545425,0.015358044,-0.022679558,-0.10802019,0.0065751295,-0.061638907,-0.084900916,0.04831275,-0.03678467,0.00460147,-0.008786412,0.1697589,0.018278342 +1.3.7.15,"The enzyme, together with EC 1.1.1.396, bacteriochlorophyllide-a dehydrogenase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. These enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. This enzyme catalyses a trans-reduction of the B-ring; the product has the (7R,8R)-configuration. In addition, the enzyme has a latent activity of EC 1.3.7.13, 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin) [4]. The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of nitrogenase (EC 1.18.6.1), which catalyses an ATP-driven reduction. ",384,0.99999994,-0.07166604,0.019719725,-0.0609249,-0.05710674,0.07808185,0.04340001,-0.05028955,0.010819253,0.06495128,-0.06766623,-0.046851885,-0.055744864,0.00087295874,0.057707757,-0.02461198,0.026330564,-0.1331507,0.022740256,-0.048911244,-0.059315503,0.010884508,0.004370346,-0.014940445,0.0014399451,-0.035902463,0.023725199,0.04265726,-0.005990009,-0.07147258,-0.09946485,-0.02591987,-0.01822915,0.040447723,-0.038546555,0.029313777,0.09796752,-0.014340937,-0.05540189,0.039053347,0.026464378,-0.008702947,0.029426979,-0.01598352,-0.065098226,-0.030910155,0.015320322,0.0012511855,0.030281026,0.030165434,-0.05619545,-0.006755133,0.009551977,-0.03865238,0.084243566,0.019838376,-0.00010916402,-0.04964926,-0.051159386,0.0071029016,0.019247036,0.032174382,-0.023936197,0.0050923014,0.018693997,0.019314172,-0.03736997,0.050223704,-0.06732651,0.015488049,-0.03240208,-0.030700644,-0.050422933,-0.015114743,0.039299216,0.021427227,0.0223531,0.06337824,0.031158283,0.008239873,-0.03339271,0.04660364,0.014558011,0.0032000279,0.03754342,0.048994288,-0.032402176,-0.040722657,-0.01998635,0.04107042,0.0037426685,0.008815776,0.010174751,-0.008204964,-0.046163637,-0.057130557,0.083001725,-0.041696567,-0.047845807,0.05896663,0.01263957,-0.018198108,0.033923775,-0.03654909,-0.08509381,0.044881787,0.028235076,0.0025648414,0.1543951,0.022610316,0.024232998,0.03642055,-0.00891122,0.08070009,0.033348277,-0.020151997,0.08200301,0.01866393,-0.02099853,-0.052086275,0.017836377,0.033835705,-0.012628344,0.028307162,0.041788492,-0.06575613,0.08870382,-0.18197636,2.7299064e-33,0.08034095,-0.014546345,0.007341213,-0.026625557,0.037115272,-0.024542151,-0.08207186,0.04609832,-0.05272115,-0.06436299,-0.029480692,-0.0575882,0.08889694,-0.09956198,-0.03528335,-0.08823762,0.022419604,0.02820833,-0.020338938,-0.003492641,0.016146993,0.09074658,-0.054139823,0.06769778,0.047699668,0.08109133,0.0021149265,-0.013993285,0.090163335,-0.019480212,-0.03494927,-0.07373922,-0.103384316,0.025775986,0.05228031,-0.064008154,-0.038724083,-0.017280836,0.016097581,0.07386745,-0.08870487,0.034658946,-0.06769092,-0.027238103,0.07739478,-0.071927615,-0.01972376,0.06584783,0.076742694,0.09728593,0.023266407,-0.015247549,0.08840786,-0.06503935,-0.07797195,0.023095867,-0.0014101806,0.019846128,0.03492313,0.075414024,0.016130738,0.0538344,-0.058477003,-0.0034372588,0.016716432,-0.0070778104,-0.03687945,-0.037369553,-0.0031119264,0.03697012,-0.08912453,0.034806915,0.09303492,0.0151741905,0.11536828,-0.03646932,-0.025250018,-0.06888472,0.027046546,0.002542273,-0.001238014,0.07956652,0.09201683,-0.045995235,-0.07907211,-0.031990867,-0.018628826,-0.08058484,-0.0054205433,-0.037715245,0.06754195,-0.07980857,-0.047236174,-0.010806023,-6.9725866e-05,-2.3688057e-33,0.10160605,-0.09004629,0.05968854,-0.08687362,-0.039279964,0.021963041,0.015665054,-0.0980404,-0.021371603,-0.0005238259,0.08031159,0.007951747,-0.0049928157,-0.013533683,0.004198038,-0.009878786,0.06348924,0.085511625,-0.0060383184,0.017115975,0.023596225,0.08714296,0.03709329,0.016496263,0.013040797,-0.012278077,0.016480913,0.07486457,0.13167495,-0.0059594475,-0.025640994,-0.039829317,-0.036940455,0.03706196,-0.002758028,0.039264437,-0.056704856,-0.019341277,0.017245596,0.025388554,0.010596529,-0.041443285,-0.056615084,0.03684907,0.027277159,0.07188212,-0.0677226,0.058312636,0.02565884,-0.038450696,-0.0051327664,0.01872082,-0.049657516,0.013023108,-0.022481399,0.016847111,0.12353558,0.0056924233,-0.004439292,0.02116333,0.023232548,-0.07321314,0.11518506,0.021469666,0.025393547,0.10235391,-0.030027809,0.08309252,0.03989411,-0.019439926,0.005944381,0.031988837,0.07388232,0.015172732,0.014219688,-0.0511732,0.012007821,-0.09718089,-0.02885837,-0.040330317,-0.06906256,0.018519642,-0.013127603,-0.071674325,-0.020736273,-0.028329903,-0.0041994634,0.03144688,0.0023478754,0.029592406,0.018668434,-0.016124206,0.0053572813,0.08528464,0.032619856,-4.7367532e-08,0.039366122,-0.03796489,-0.005111495,-0.058344766,0.04768408,0.036899615,-0.033451498,-0.041153114,0.062514305,-0.076943874,0.027547196,0.047932994,0.035129625,-0.01486696,0.014511405,0.02584835,-0.018188598,-0.056715835,-0.012897613,0.0017174429,-0.04085496,-0.028986132,-0.14289983,0.0596776,0.012749554,-0.06422597,-0.023387337,0.04812717,0.002965581,-0.059007395,-0.02141925,0.03359388,-0.037002634,0.009137257,-0.0068890257,-0.021279182,-0.05494498,0.024846107,-0.035824783,0.0828352,0.07141307,-0.04302714,-0.08137282,0.068561174,0.048363026,0.018375285,-0.034761816,-0.0107796285,0.0046429145,0.060276914,0.06181914,-0.02685362,0.04081491,-0.020958444,-0.12951759,0.00028940494,-0.03300391,-0.10702274,-0.029473362,-0.018720066,0.0010164465,-0.045200013,0.18144892,0.016543634 +1.3.98.3,"This enzyme differs from EC 1.3.3.3, coproporphyrinogen oxidase, by using S-adenosyl-L-methionine (AdoMet) instead of oxygen as oxidant. It occurs mainly in bacteria, whereas eukaryotes use the oxygen-dependent oxidase. The reaction starts by using an electron from the reduced form of the enzyme's [4Fe-4S] cluster to split AdoMet into methionine and the radical 5'-deoxyadenosin-5'-yl. This radical initiates attack on the 2-carboxyethyl groups, leading to their conversion into vinyl groups. This conversion, ---(.)CH-CH2-COO- -> ---CH=CH2 + CO2 + e- replaces the electron initially used.",384,1.0,-0.06299183,-0.0017163208,-0.059736706,0.06227384,0.13160788,0.016957685,-0.08097984,0.028203066,0.029530874,0.0018977391,0.028938405,-0.07177126,-0.11125873,0.0061561833,-0.00667919,0.0335122,-0.08541896,0.012656748,-0.026984908,-0.00092676264,0.028967375,0.02508138,0.01674154,-0.052578676,0.050465792,-0.03227961,-0.0015568724,0.01613189,-0.04548367,-0.067960866,0.09702472,-0.059304215,0.07083568,-0.027901908,0.024569714,0.03527571,-0.02417217,-0.12168716,0.0370206,0.022426005,0.012372862,0.015077975,-0.062076267,-0.012090516,-0.012743145,-0.027157981,-0.042214677,0.006238167,0.024780512,-0.036818586,-0.020273676,-0.021108652,-0.053088658,-0.017238362,-0.046967085,0.007339841,-0.0012152599,0.094843715,0.0047791894,-0.046569843,0.091872975,-0.023013785,-0.025498472,0.007618976,-0.04860831,-0.06502748,0.09687481,-0.055978898,0.06308349,-0.012270633,-0.041223586,-0.046076987,-0.0061181313,0.034449257,-0.02478412,0.0017041519,-0.036826428,-0.060291886,0.047853146,-0.0041995854,0.05526454,-0.012874934,0.0056898477,0.026556933,0.06674639,0.06262008,-0.024152273,-0.026569944,-0.0037053272,-0.011506555,-0.018973844,-0.0023556072,-0.003201706,-0.009549908,-0.02120506,0.018649962,0.09389948,0.09286423,0.01640907,-0.022368222,0.0019147183,0.1111446,-0.054736327,-0.1213922,-0.02277628,0.0042102933,0.070077665,0.06911025,0.01125982,0.042941216,0.020962823,-0.022210406,0.023815682,-0.0592117,-0.05428935,0.14380127,-0.022894591,-0.048245978,-0.008456559,0.043893117,0.08366025,-0.103757575,0.026648182,0.0434739,-0.06703291,0.043165684,-0.087322876,2.0180035e-33,0.060056373,0.04883884,-0.013062755,0.0011818209,0.04651528,-0.020646714,-0.13592784,-0.024652908,-0.030668812,0.008823737,-0.08409945,-0.037970714,0.08201054,0.021442654,-0.071553916,-0.0455919,-0.11936352,-0.019024968,0.0063709216,0.030223029,0.004213499,0.018348908,-0.07729025,0.077817485,-0.024721052,-0.022066552,-0.010912732,0.0403269,0.05206305,0.028134523,-0.07357589,-0.061108004,-0.082769305,0.039658085,-0.023421293,0.039177287,-0.06339031,-0.06695273,0.041162703,0.0134084085,0.028422201,0.018183446,0.009304801,-0.050910484,0.10253197,-0.01416808,-0.07535098,0.06603676,0.06305792,0.09349877,0.007614392,-0.027009247,0.09143596,0.020346973,-0.07446057,-0.0027800726,-0.0060571074,-0.02858751,0.011138201,0.07885715,0.001289056,0.07459444,0.028298656,0.015120731,-0.01660824,0.062152006,-0.036978535,-0.04656087,-0.009937848,0.050901223,-0.004491989,0.008321211,0.05614579,0.02587038,0.051495902,0.047577687,-0.023372512,0.07397227,0.028105576,-0.018357392,-0.004296985,0.015622664,-0.007062268,-0.07599653,-0.029377356,0.0060335426,-0.028024528,0.016568283,-0.013521611,0.036369238,0.07276914,-0.1053253,-0.0009647606,-0.024387712,-0.04001287,-3.6192336e-33,0.065275215,0.0051443237,0.030391619,-0.119754694,-0.038503077,0.074787125,-0.046921477,-0.04236229,0.060624704,-0.0078967195,0.06989322,-0.032618392,0.02385212,-0.043251395,0.051174283,-0.009686674,-0.051091693,0.022307146,-0.0016480848,0.03183947,0.09801892,0.013325465,0.0115594985,0.07240303,0.086707614,-0.021280628,-0.0055226604,-0.022481943,0.10077548,0.03859319,0.0027312099,-0.05369004,0.004608516,0.027918484,0.019467968,0.04380024,-0.069452934,0.06722963,0.01099241,-0.0061812126,-0.039788175,-0.023591114,0.03025875,0.043982606,0.057158537,0.058719527,-0.073478945,0.018121114,-0.017007245,-0.092506744,0.033049054,-0.0051397504,-0.009738734,-0.052485988,0.0026910354,0.1321686,0.04319309,0.004516478,-0.07944096,0.01979138,-0.02638906,-0.023090208,0.065517604,0.0067526596,-0.011331134,0.01916354,-0.028230207,0.06581603,0.0037113333,0.008082973,-0.028974295,0.03702723,0.015245682,0.024184912,-0.06157594,-0.06900558,-0.10454223,-0.023393534,0.0044350172,-0.034391135,-0.014812452,-0.0291997,0.042549808,-0.08013635,-0.05891392,-0.013168621,-0.0028685709,0.06928825,0.017458355,0.037418846,-0.06108401,-0.0016988297,-0.0070073074,0.07872285,0.07159602,-5.2932723e-08,0.07004837,-0.022904873,0.09472102,-0.036731094,-0.0067831236,0.032475103,0.0066608847,-0.032346915,0.039442692,-0.037517488,-0.022095129,0.09747379,0.0128048,-0.012851163,0.0013533274,0.028695976,-0.06648602,0.04004195,-0.020277089,0.014983345,-0.047307577,-0.029234873,-0.078413166,0.023832994,-0.016750047,-0.029002609,0.044654276,0.097744845,-0.00049503497,-0.059847407,-0.026975745,0.022259735,-0.07591585,0.017903548,-0.14078568,-0.019954741,-0.081218734,-0.06142004,-0.08779755,0.040570043,0.007867438,-0.04316408,-0.05003723,0.06887322,0.017608967,-0.010260677,0.050678577,-0.009252868,-0.015124012,-0.035028286,0.059699137,-0.04929867,-0.046588723,-0.043804273,-0.11551816,0.043596383,-0.10922513,0.055568323,0.011295964,-0.009178442,-0.051058028,0.04445767,0.16763377,0.062108956 +1.7.2.7,"The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only a few enzymes that are known to form an N-N bond (other examples include EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming] and EC 4.8.1.1, L-piperazate synthase). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is a dimer of heterotrimers and contains multiple c-type cytochromes.",384,1.0,-0.038253944,0.0028508294,-0.11939367,-0.03727807,-0.024798464,0.036658086,-0.041197896,-0.0045428467,0.01755513,-0.026744807,-0.052323025,-0.063689075,-0.08444027,0.063858174,-0.06738319,0.060244136,-0.07921583,-0.035737224,0.040375,-0.005974066,0.018787473,0.056425117,0.016360214,-0.040047508,0.041378357,0.02575646,0.05862087,-0.026708705,-0.018805519,-0.099087216,-0.023683704,-0.027691053,0.101314895,-0.041813556,0.119335026,0.029000003,-0.027695302,-0.037868164,0.020210693,0.031859383,0.027099628,0.05343186,-0.0273971,0.0063890447,0.0021125718,0.012210543,-0.008619155,0.011945159,0.0618768,-0.026971983,-0.028799335,-0.07301299,-0.030876843,0.035301797,0.073100604,-0.01728051,-0.110900305,-0.06622832,-0.05406869,0.027686847,0.100245126,0.018290164,0.04056764,-0.03529988,0.037138935,-0.01375218,0.05521152,-0.08711035,-0.025628315,-0.057694312,-0.08560775,-0.1067305,-0.053907104,-0.018772345,-0.029263098,0.0108089475,0.029878652,-0.01727619,0.032410223,-0.008865079,-0.043165714,0.0785499,0.0087998845,0.0495935,0.043299682,-0.0053027864,0.00943423,0.030239725,0.062341575,0.011307507,-0.0767728,0.045892656,0.045147326,-0.05253617,-0.042553023,-0.010852989,-0.0031233975,0.15333074,0.01026433,-0.013623013,0.08254689,0.11063828,-0.06352078,-0.06612542,-0.025917774,0.030711403,0.059236106,0.0923263,0.07451921,0.049486116,-0.030293956,0.020471351,0.016125605,-0.04957026,-0.016138481,-0.05262931,-0.011803275,-0.020100957,-0.03464747,0.08792943,0.021112937,-0.05218294,-0.024798231,0.02969469,0.009636274,0.032209784,-0.11319428,1.2603773e-33,0.10478132,0.017740188,0.01004718,0.028571764,-0.008168572,0.030825924,-0.07755979,0.019227335,-0.027624626,-0.057025157,-0.07911012,-0.01125778,0.07803935,-0.034352064,-0.019895906,0.05617412,-0.03557669,0.034244504,0.041907787,0.073774666,-0.013240354,0.04936819,-0.06023205,0.008893642,-0.018838376,0.016927943,-0.013391799,-0.035790842,0.040160976,-0.035709884,0.059834693,-0.1157945,-0.09124485,0.0077756243,-0.006690344,-0.01062806,0.0069441316,0.06270948,-0.05317309,0.024171425,-0.07725484,0.06603834,0.006038224,-0.023277003,0.052681424,-0.026586672,-0.06916327,0.065688044,0.05902123,0.049293898,-0.008613378,-0.03662366,0.07212437,-0.0058562956,-0.015080839,0.10920648,0.0144101335,0.07926319,0.0051426217,0.034975164,-0.023484595,0.029536296,-0.064399034,0.038834468,0.0065187393,0.04787753,0.00031951955,-0.011378681,0.03296388,0.10355803,-0.1033696,0.008224913,0.005085778,0.051108275,-0.013948352,-0.10158392,-0.052438658,-0.054462533,0.003945534,0.04187833,0.033926304,-0.004295369,0.060684226,-0.09062662,-0.045135688,-0.055631943,-0.02662461,-0.019903503,0.02112854,0.0373602,0.058741014,-0.07939549,-0.09799117,-0.061266698,0.0071429606,-2.1950629e-33,0.12698023,-0.07830475,-0.026145445,-0.085544564,-0.045608457,0.05682581,-0.026628243,0.005707409,-0.046282504,-0.032296874,0.11278728,-0.004407985,0.08921677,0.026523013,0.028586207,-0.03957152,0.0014363043,0.07345556,0.043782864,-0.011025447,-0.05427633,0.05821329,-0.03711981,-0.032375168,-0.00045819537,0.032213017,-0.07278177,0.08354724,0.07572271,-0.023783455,-0.035145428,0.019518096,-0.025719404,-0.060385544,0.025430879,0.07857035,-0.02134622,-0.020732637,0.004830215,0.0054274066,-0.004094192,0.026930457,0.02300316,0.030325886,-0.004188364,0.05598418,-0.106328994,0.025660748,0.0014573118,-0.009414655,0.028004061,-0.0017816356,-0.050375022,-0.01645247,0.038737275,0.053369373,-0.032131918,0.04752854,0.0528992,0.023878178,0.017992081,-0.054263253,0.026167534,-0.009374002,-0.04918451,0.016049594,-0.04946127,0.04238082,0.017594652,0.031020088,0.009583225,0.085111395,0.046386566,0.051923793,-0.0792791,-0.0672534,0.0062703886,-0.06426274,0.019051787,-0.021116799,0.02866515,0.0025129344,0.028872924,-0.020798609,0.004246461,-0.002662323,0.08603752,0.057175994,-0.033058718,0.03843603,0.030075219,-0.009905009,-0.050534513,0.09798074,-0.029602125,-4.4693678e-08,0.069381826,-0.049814586,0.06382735,-0.06430156,0.018847628,0.04444574,-0.008585123,-0.07191198,0.07352552,-0.0184469,0.071757,0.08648586,-0.05501972,0.0035526536,0.053044483,-0.014415608,-0.02251204,-0.054593544,-0.029678145,0.053948797,-0.075903036,0.018560844,-0.11520999,0.039995257,0.015151858,-0.045176543,0.041066397,-0.0033234127,0.020380484,-0.005180746,-0.06434096,0.06073534,0.06054688,-0.04545032,-0.09271322,-0.028888935,-0.02136122,-0.012342049,-0.012955468,-0.023973705,0.03194576,-0.0901552,-0.08218738,-0.011558325,0.02488923,-0.0002529917,-0.008305891,-0.039110035,-0.03872164,-0.063549936,0.016745513,-0.014916781,0.005746122,-0.041874908,-0.11346106,0.080109015,0.016956747,-0.039989494,0.024905305,-0.046418414,-0.00996132,-0.0263357,0.17960955,-0.014870121 +1.7.2.8,"The enzyme, which is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria, has been purified from the bacterium Candidatus Kuenenia stuttgartiensis. The electrons derived from hydrazine are eventually transferred to the quinone pool.",384,1.0,-0.042558864,0.07158623,-0.04638739,-0.048142806,0.07032206,-0.013179137,0.005844356,-0.028895555,-0.030846598,0.07966599,-0.035051953,-0.11572066,0.004547068,0.020432895,-0.12045498,0.105019815,-0.06873887,-0.032171052,0.0011600724,0.00801495,0.02887648,0.016069464,-0.0022000226,-0.02034379,0.061618626,0.04593181,0.01484761,0.008014425,-0.050953776,-0.09492289,-0.027664255,0.01729567,0.09082674,-0.04921305,0.03523859,0.13328834,-0.019140314,-0.037373003,0.07259142,0.025027376,0.024293503,0.016951263,-0.0042577065,-0.026254494,-0.007558057,0.06584206,0.069171295,-0.02514163,0.053001966,-0.0063594715,-0.010250004,-0.030800615,-0.021556476,-0.011644204,0.019013006,0.02385016,0.013039114,-0.040443707,-0.06571607,0.03256128,0.033876862,-0.01305047,-0.018453738,0.01101846,-0.026020957,-0.122351006,0.034864403,-0.011230283,0.029384438,-0.09138611,-0.046501134,-0.07381848,-0.023669029,-0.06340473,-0.009598113,0.015338587,0.092732824,-0.03649308,0.022176085,-0.014748755,-0.02405429,0.0073745786,0.0724588,-0.020875273,0.04111496,0.019057397,0.0091500515,-0.018025294,0.04621341,0.0013915291,-0.043657515,0.038417257,0.04450594,-0.083767526,0.0036647643,0.027002255,0.00869559,0.09838775,0.037296318,0.017925415,0.047044113,0.08719715,-0.09414083,-0.104834825,0.023656875,-0.0007734103,0.07840592,0.12326933,0.050187092,0.04039417,-0.035491776,-0.026352463,0.10074825,0.0055337683,0.047590822,0.052000694,0.03500742,-0.03551478,-0.06022781,0.037203394,-0.007034781,-0.06894791,0.014717603,-0.007748556,0.0068588676,0.06671481,-0.014574216,3.7511535e-33,0.10276088,0.030032724,-0.03623241,0.037271045,-0.056514923,0.0136415465,-0.030447409,-0.0013222062,0.012884856,-0.12942946,-0.10068309,-0.022155186,0.007638127,-0.029523324,-0.109836884,-0.004222577,-0.031956527,-0.07612521,0.018411394,0.027647149,-0.014844806,0.0060476805,-0.061937153,-0.021697043,0.020658687,0.026065994,0.058895785,-0.014859101,0.016119469,-0.039493334,0.08309482,-0.051682036,-0.13247347,0.029820444,-0.047194324,-9.026618e-06,-0.0025754254,0.06373935,-0.04464185,0.050023213,-0.029880188,0.10184551,0.021280993,-0.06679061,0.013251818,0.029616257,-0.042395238,0.06739297,0.11348091,0.029641224,0.006636247,-0.010402399,0.06530084,-0.08321807,-0.042284563,0.05316023,0.04766551,0.024084384,0.0692741,0.05470169,0.0067283055,0.07007652,-0.03920987,0.111170016,0.030560298,0.074984044,-0.026587801,0.011569792,0.052148607,0.087149575,-0.14084072,-0.016598113,0.025817296,0.048431423,-0.048948336,-0.030950934,-0.07713823,-0.0790569,-0.031696815,-0.04834935,0.09153939,-0.03301511,0.052043222,-0.02490999,-0.015189424,-0.07373144,0.0029496662,0.0043217707,0.035252023,-0.02254948,0.11928203,-0.07849636,-0.05116487,-0.052267026,-0.027699579,-3.3394498e-33,0.13915437,-0.033647943,-0.024301292,-0.08045103,-0.04680383,0.064284414,0.019061187,0.03656491,-0.012499337,0.0032491998,0.05264215,0.00034082995,0.07790523,0.0066434853,0.052583583,-0.061804432,0.033004433,0.028041793,-0.032305032,-0.044005994,-0.04514251,0.099680744,-0.032361086,-0.055016313,0.015322428,0.02832178,-0.03253794,0.05614947,0.05353798,-0.011753067,-0.05139939,-0.021851338,-0.018920427,-0.01151944,0.007523222,0.03663582,-0.0348549,-0.005319272,-0.013940273,0.012447032,0.01775067,-0.015457343,-0.043162312,0.016447147,-0.017442333,0.04622066,-0.15117688,-0.0078092995,-0.022109635,-0.055850897,0.023330726,-0.011162654,-0.016285261,-0.040317602,0.011162747,0.05765855,0.022827806,0.005538544,0.036151607,-0.03293906,-0.019215489,-0.026068391,0.037818003,-0.07411645,-0.06086776,0.08502254,-0.011442034,0.07257402,-0.010388112,0.008635676,0.026533416,0.0711181,0.023825414,0.023785884,-0.03355076,-0.020874698,-0.052130654,-0.017564313,0.029062655,0.0107317,0.0026191347,0.004811495,0.014363022,-0.012344799,-0.0022282891,-0.05182923,0.012508769,-0.009478409,-0.03700968,-0.008994961,0.035645716,-0.036496017,-0.054799564,0.10869074,0.030144269,-3.4147664e-08,0.040505424,-0.037756737,0.10264958,0.037459463,-0.027470829,0.07433847,0.006979707,0.018828245,0.086306155,-0.03952951,0.0069024945,0.09372907,0.028661683,-0.021013858,0.03773738,0.033187576,-0.029588722,-0.020335881,-0.059816472,0.017610116,-0.05107511,-0.008733707,-0.11177336,0.07596071,0.03367003,-0.018180095,0.025720822,0.0024073743,-0.019952662,-0.052659977,-0.083229445,0.036692616,0.0103303,-0.009305314,-0.098796554,-0.005222593,0.008096453,-0.012718085,-0.035904612,-0.026942274,0.028121501,-0.06677974,-0.0806734,-0.017603476,0.025476743,0.0020060313,-0.02553069,-0.060105804,-0.006454127,-0.051824074,0.06510232,-0.0038027791,0.014871457,0.012180324,-0.082063675,0.047929853,-0.046186496,-0.032575596,-0.03530086,0.0027137531,-0.013699984,-0.015343781,0.19456732,-0.07238796 +1.14.11.51,"Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome.",384,1.0,-0.052747548,-0.0162638,-0.078079544,0.060058523,0.020098606,0.0033851385,0.05193599,0.010276034,-0.056017198,-0.05861195,-0.017691843,0.048144616,-0.03794898,-0.058417942,0.014923822,0.07495354,-0.064450614,0.021962367,-0.032306343,-0.010031597,-0.023018586,0.007883592,0.08157917,-0.03622775,-0.022345887,0.012755566,0.089146756,0.022880875,0.048044194,-0.035969988,-0.0038755303,0.04673443,0.012688207,-0.018353352,-0.007914425,-0.0056610415,0.06581191,-0.06434687,-0.013506958,-0.051090427,0.03324979,-0.03745439,-0.029477887,-0.00085980585,-0.013844575,-0.0755663,0.03218802,-0.028132437,-0.03928714,0.13134165,0.025359316,0.033853877,-0.015110764,0.078756,0.067561984,0.002300433,-0.00831918,-0.07534931,-0.000960657,0.07522343,0.05096897,0.0032184022,0.0063730166,-0.008136367,0.023863997,-0.016334089,0.09911694,-0.011105406,0.00067260157,-0.07287291,0.0063619944,-0.012458419,-0.0831465,-0.016995827,-0.060794916,0.047444712,0.117253765,-0.09564554,0.01805395,-0.014751263,-0.06756006,0.021825919,0.06501658,0.113354474,0.023884006,0.035404477,-0.01915318,0.019749887,-0.027258793,0.13709512,-0.044765938,0.031257022,0.06890824,-0.06596752,-0.030350924,0.038818333,0.043716602,0.034561966,0.036718402,0.007272554,-0.021092847,0.09441169,-0.04340601,0.017545808,-0.0039963927,-0.0050532124,-0.01422253,0.09910311,-0.06692485,0.0013322926,0.019624319,-0.019542132,0.048002306,0.04856263,-0.04940349,-0.050525624,0.11135164,0.01772209,-0.06051573,0.0010687112,0.04018508,0.0606209,-0.0046897894,0.051545814,-0.005225778,-0.06140521,-0.044560667,1.0976465e-33,-0.005242717,0.064959414,0.05314165,0.024836851,-0.0069903685,0.053367913,-0.06638729,0.049569834,-0.061529264,0.04220416,-0.08014818,-0.10116904,0.07284357,0.03849449,-0.023817122,-0.0866298,-0.01370073,-0.021118904,0.012929362,-0.0012802614,-0.0074720234,0.0061679203,0.006026213,-0.084562704,-0.059373796,0.024111426,-0.020322407,0.0340335,0.0006781009,-0.031460922,-0.050453585,-0.07624972,-0.022856982,0.05196545,0.01386684,0.06402074,0.018873293,-0.054938216,0.005547015,0.09599078,0.010198873,0.011365944,-0.0035452084,-0.07468148,0.03455412,-0.040789515,-0.050804485,-0.010000186,-0.06553912,0.01829066,-0.036624376,0.025372779,0.037496064,-0.036000673,0.00860458,-0.04573237,-0.06693573,0.023127107,0.017407883,0.0917269,-0.010331777,-0.045434944,-0.0010194372,0.030401304,0.06536774,-0.057788294,-0.041564878,-0.03543767,-0.015640054,0.03947195,-0.013270828,0.0028065052,0.11835969,-0.01862611,0.078027725,-0.01251623,-0.10712846,0.048027407,0.053949617,0.038598,-0.002975781,-0.021878848,-0.010062235,-0.05575444,-0.031950884,0.05111466,-0.011872732,-0.050153565,0.0055324184,-0.064931795,0.048131123,-0.09702431,-0.063103035,-0.09468661,-0.0037196795,-2.0748842e-33,-0.03721877,-0.057280347,0.040354684,-0.08790365,-0.056172054,-0.048407163,0.03652611,-0.036827613,-0.051592212,0.033640925,0.08661758,-0.0005761967,-0.027849276,-0.12234503,0.010680899,0.037250526,0.06796445,0.08667531,0.07530572,-0.042094972,-0.018086541,0.053620555,-0.053366963,0.070928484,0.023602344,-0.012410494,-0.0017496933,-0.026539829,0.13022916,0.07269298,-0.060396582,-0.0029072724,-0.02510008,-0.058072582,0.077001214,-0.0047137747,0.0049059414,0.081396565,0.03355832,0.021441562,-0.045599133,0.045340348,0.020077566,0.12251951,0.051922675,0.0809632,-0.12014864,0.06465016,0.020163858,0.051204015,0.058450893,-0.0024733027,-0.0440389,0.036887776,0.073102035,-0.03162522,0.07265957,-0.025140852,0.00016813647,0.041495886,-0.025108684,0.009412489,0.0341238,-0.030728115,0.027097952,0.03090478,-0.022917425,0.06824463,-0.024304973,-0.04871322,0.058508966,0.0075345407,0.0063390504,-0.09291343,-0.024138369,-0.049582377,0.00967194,-0.015591438,-0.06101341,0.005314465,0.04545211,-0.07276515,-0.031928543,-0.0138606075,0.011659055,-0.044222746,0.030549303,0.11029481,-0.057795312,-0.05716549,-0.07898809,-0.0619245,-0.09969738,0.0053738276,0.027726311,-2.9755798e-08,-0.035781726,-0.086095974,-0.009961119,-0.06230496,-0.015389453,0.118493326,-0.03833402,-0.0016767209,0.055152822,-0.006020544,0.0060924217,0.10456598,-0.019467192,0.017309403,-0.0071488502,-0.01477617,-0.027872251,0.02610918,-0.016685385,0.00089460664,-0.03768722,0.026149804,-0.067820884,-0.0041166022,-0.02200286,-0.04835217,0.00018047723,-0.055694368,0.06877141,-0.07915763,0.0007813242,0.025903426,0.034508955,0.0093442565,-0.024695138,-0.06407767,0.08742685,-0.03180102,-0.00081177254,0.03970345,0.013400136,-0.029938156,-0.062164165,0.0075006434,-0.0027315037,-0.012109059,-0.0201273,0.031893477,-0.086636916,0.00016480828,0.07853161,-0.0020407366,0.043787368,-0.09708682,-0.07019502,0.055174053,0.022928674,-0.023154372,0.05752311,0.010211608,0.02111605,0.01172606,0.17734978,-0.11271568 +1.14.11.52,The enzyme was characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus. Requires Fe2+.,384,1.0,0.007746284,0.01579975,-0.1688375,0.056283724,0.03737917,0.056080535,-0.08557065,0.06859131,0.0285405,-0.11069879,-0.0273489,-0.039192695,-0.033070695,0.01325156,-0.094480015,-0.077487454,-0.033731397,-0.03636927,0.05005001,-0.033548202,0.12724829,0.042115968,0.022110984,-0.04493047,-0.030209227,-0.010333321,0.018274771,0.00042557294,-0.068709075,-0.060359653,0.015097479,-0.015641475,0.076650724,-0.03846314,0.06785749,0.053802624,0.010149482,-0.080361485,0.08818636,0.014924638,-0.0070973546,-0.0048074033,-0.046846233,0.011260047,-0.07372457,-0.004577129,0.098032564,0.043643653,0.066059455,-0.01639497,-0.08089665,-0.06458181,-0.055254664,0.016257182,0.021546029,0.019981029,0.006150842,0.004796475,-0.00011372144,-0.098798506,0.03428145,-0.0088217165,0.032117564,0.038714595,-0.060571954,-0.0226008,0.034989394,-0.086054504,0.027997825,0.004542666,-0.056983072,-0.0021400761,-0.07681561,0.00997943,-0.0032673983,0.04461685,0.033867493,-0.07406841,0.060443893,-0.014470087,0.015924208,0.0046190415,-0.024563106,0.05811794,-0.0064542117,0.026229199,-0.021586342,-0.028557852,0.0039445716,0.025921252,0.06692756,-0.023962688,-0.037455954,-0.060705923,-0.012312936,0.0010000708,0.006675781,0.0117949955,0.06057925,-0.020275488,-0.071817,0.028666899,0.042229142,-0.021613033,-0.047157425,0.023547163,-0.03733222,0.06804517,0.07133303,-0.03584023,0.01647351,0.021985857,0.048374005,-0.040855657,0.030213995,0.06205718,0.101703845,-0.06404021,-0.05693801,-0.011346587,0.0892362,0.0056929034,0.008846613,0.007450142,-0.047600843,0.018351305,-0.1391413,1.705933e-33,-0.018195596,0.017125398,0.057909664,-0.04165268,0.043264404,-0.023742365,-0.07801121,0.003089941,0.00758562,0.008166222,-0.092874184,-0.118326396,0.004821983,-0.009839405,-0.019675741,-0.030092485,0.026803344,0.03671325,0.025315171,0.012326023,-0.00012957874,0.05037818,0.021479987,-0.022281649,0.06485973,0.08239186,0.0017414374,-0.003325473,0.10197199,-0.024768993,0.076409906,-0.10435167,-0.06640858,0.021093048,0.04671626,-0.037651647,-0.051249444,-0.035212513,0.011853248,-0.053645816,0.023128593,0.07786514,0.030177232,-0.025147099,0.028154967,-0.08070459,-0.055110883,0.113808565,0.0714052,0.108806476,0.016579563,0.010089126,0.10661186,-0.024618158,-0.06491754,0.030480623,-0.02253407,0.074215285,0.04216264,0.045600124,0.029427221,0.10230946,0.07116936,0.04204279,0.06724477,-0.0011695058,-0.08281916,0.05783497,0.011213075,0.11549191,-0.06909424,0.030093187,0.028236626,0.00961765,0.05269796,-0.054639276,-0.05056107,-0.07679707,0.08854997,-0.020179339,-0.06948732,-0.030819032,0.06418562,-0.06201704,-0.0674089,0.011215448,-0.05950218,0.0028157055,-0.004684735,0.08686884,-0.045053948,-0.0073651476,-0.08295691,0.032751992,0.022896854,-3.763291e-33,0.052708026,-0.075228095,0.07059713,-0.03213852,-0.037333194,0.11121788,-0.0627588,-0.040787052,-0.05824733,-0.016494565,0.08765507,-0.007427719,0.027448967,-0.1031346,0.046381354,0.04477557,-0.056024723,0.038575247,-0.010724668,0.04061828,-0.0457415,0.079379804,-0.024549713,-0.043365102,0.019891897,-0.018880716,-0.025739089,0.054972537,0.0048715123,0.06895576,0.06836579,-0.0007536344,-0.050166033,-0.027604435,-0.039360557,0.020711085,0.012288118,-0.008637414,0.11601028,0.0091604665,0.07306296,-0.00025720123,0.028343717,0.090572745,0.020571131,0.04627492,-0.05364118,0.013777924,0.02904772,0.011075157,-0.04501381,0.011964239,-0.08682126,0.009342937,0.010264125,0.030038122,0.02796689,-0.0016460235,-0.063373394,-0.028711924,-0.061021816,-0.055630345,0.015898298,0.017042391,0.08577934,-0.006526555,-0.019686393,0.080150895,0.08288896,-0.04088017,0.09312832,0.034173496,-0.018555539,0.041231155,-0.01715217,-0.010048648,-0.05450135,0.010492554,0.014044982,0.027442243,0.024021316,0.00031314415,0.013780428,-0.053482354,0.040172588,-0.10130642,0.029246273,0.035569105,-0.032963768,0.030231183,-0.0072851744,-0.02789759,-0.02946274,-0.024101766,0.03827945,-2.6583159e-08,-0.024054395,-0.0469238,0.09104004,-0.034303512,0.012169355,-0.037810147,-0.034321234,-0.010668945,-0.03173752,-0.0128512485,-0.042355243,-0.008722302,0.02088922,-0.026011372,-0.0037356422,-0.0423196,-0.07198248,0.03763798,-0.007933836,0.010485204,-0.081594504,-0.036254164,-0.14365686,0.05189809,0.043839205,-0.086702295,-0.0043772496,-0.014108523,0.0027159362,-0.006461702,0.001675507,0.025020834,-0.063378215,-0.047042128,-0.07583851,-0.03426395,-0.08386383,-0.047741745,-0.0224602,0.024538757,0.0452473,0.020133603,-0.0257746,-0.024594402,-0.05430108,0.02537066,-0.01245827,0.009203271,-0.0634308,0.0024785763,0.08987453,0.0014938522,0.041833725,-0.008101303,-0.08071076,0.054155096,0.029135855,0.0035944956,-0.007326626,-0.03895479,0.027868934,0.014757107,0.15310924,-0.06676141 +1.14.11.53,"Contains iron(II). Catalyses oxidative demethylation of mRNA N6-methyladenine. The FTO enzyme from human can also demethylate N3-methylthymine from single stranded DNA and N3-methyluridine from single stranded RNA [1,2] with low activity [3].",384,1.0,-0.009653332,-0.027471937,-0.09352886,0.09432262,0.07473627,0.017692864,-0.002742266,0.0027782097,-0.04886765,-0.059062675,-0.026577046,0.046558116,-0.05615236,0.00011593654,0.026680753,0.07128627,-0.043776702,0.003450719,-0.03198089,0.01604296,0.00064655265,0.05475804,0.021062965,-0.0526999,-0.025257505,0.0184969,0.11173076,-0.013080281,0.02058681,-0.01214734,-0.022658568,-0.022098763,0.0191967,-0.015117302,0.054103486,0.045411643,0.024387278,-0.060538877,-0.01338397,0.058270175,0.008981534,-0.047773067,-0.005100817,-0.035235353,-0.025421906,-0.0763442,0.045240276,-0.0083468575,0.01983873,0.067453414,-0.0044088997,-0.005118817,-0.02467011,0.06061487,0.043070287,-0.010774345,-0.0057701957,-0.060322616,-0.06645185,0.023193115,0.014786775,-0.027418919,-0.0073087825,-0.01598885,0.09191559,0.010811708,0.09116989,0.022921955,-0.0105792675,-0.07314517,-0.024731347,-0.029368494,-0.050919473,-0.004468465,-0.0485389,-0.008568137,0.09760969,-0.07425464,0.10974415,-0.029390901,-0.04171553,-0.009265791,0.055342443,0.057330064,-0.0061365366,0.104058005,-0.028516082,0.06724595,-0.03702785,0.07327859,-0.009419372,0.022742864,-0.015566129,-0.083145425,-0.022542631,0.057671834,-0.010014596,0.06509974,0.0174025,-0.02064678,-0.024237493,0.07265751,-0.11837171,-0.037483938,0.017299091,0.04716575,0.008761408,0.09632871,-0.007781344,0.06915916,-0.02989699,0.001596226,0.034636885,0.05579397,-0.027529653,-0.010564247,0.040113423,-0.02462541,-0.059990104,0.0031130025,0.046363007,0.05812777,0.043851368,0.045435403,-0.01128436,-0.027369317,-0.074107535,4.173371e-33,0.00603565,0.0540709,0.015656665,-0.0036950351,0.011450171,0.041355114,-0.07882233,0.043292142,-0.060346402,0.050006308,-0.10958822,-0.05650174,0.025742976,0.010197169,-0.0020432589,-0.08263383,-0.011267646,2.9761846e-05,0.02423175,-0.047611922,0.052169655,0.05818966,0.044077322,-0.035506275,-0.0777775,0.056587566,0.011425206,-0.0046068025,0.036653932,-0.040200476,-0.06292659,-0.07748911,-0.026743444,-0.010626387,0.08375515,0.0174353,-0.049488276,0.019796038,-0.052789137,0.09775909,0.05943393,0.0471453,-0.031028744,-0.0772482,0.009381527,-0.07783342,-0.10269953,-0.003956975,-0.058584884,0.0028359187,0.015581287,0.025047127,0.031980447,-0.0789208,-0.026806265,-0.056206647,-0.079762384,0.0047150273,0.075433895,0.052959178,-0.06678417,-0.023898372,0.018384773,-0.0022313022,0.05329695,-0.057228502,-0.07074438,0.015666302,0.013979879,0.07954897,0.014261826,0.020218443,0.11713068,0.0062197545,0.020150222,-0.021297075,-0.04533415,0.0026535417,0.053960204,0.012345433,0.007444461,-0.04721025,0.017906299,-0.024666287,-0.0023744206,0.049548347,-0.0077464706,-0.064775966,0.013611704,-0.028157417,0.03556437,-0.061102938,-0.075623676,-0.1369831,0.04289996,-4.6813618e-33,0.048661128,-0.037221175,0.021940274,-0.12536138,-0.027871188,-0.010974952,0.029834945,-0.071694486,-0.03309038,-0.0032926023,0.07232812,0.013519194,0.013397976,-0.1167869,0.00669738,0.041876473,0.025164273,0.07958589,0.0697301,-0.049790177,-0.037409753,0.038821783,-0.091898955,0.052116524,0.04336377,-0.0130047165,-0.035987012,0.02947281,0.098240726,0.06374987,-0.0031559574,-0.0133725535,-0.026023807,-0.053320285,0.03506649,0.021791678,-0.011239289,0.041340865,0.058992583,0.042543836,-0.00651727,0.040996615,-0.006816036,0.08852314,0.02299597,0.037356243,-0.1612883,-0.04120305,-0.0106868455,0.023069257,0.08257637,-0.07114755,-0.060529254,-0.007163345,0.091784306,-0.05225057,0.08593745,0.0091915745,0.014563295,0.0014923614,-0.05211812,-0.0069775814,0.036054946,-0.01734942,0.053738505,0.06827893,-0.009470277,0.07168881,-0.051716708,-0.029679632,0.09536859,0.038546324,0.0449027,-0.049825322,0.020158257,-0.033318937,-0.026212726,0.044894997,-0.069954574,-0.0063710394,0.031177005,-0.0791974,-0.067714274,0.006643592,-0.020919256,-0.03810218,0.07993101,0.08887692,-0.021036645,-0.032460496,-0.07007791,-0.06407659,-0.024916576,0.018064883,0.020987721,-3.5228144e-08,-0.09280243,-0.09423791,-0.0057835076,-0.059416685,0.0121120745,0.0910939,-0.020572,0.013250322,0.015140817,-0.026461657,0.024271674,0.053463675,-0.012160378,-0.01275509,0.04065727,-0.029480604,-0.051762793,0.056383,-0.009170445,-0.01253009,-0.046745505,0.102955416,-0.100161664,0.02149479,-0.008339671,-0.026808653,0.0042004264,-0.041354243,0.06711955,-0.07356293,0.019083103,0.029242769,0.043487355,-0.06380957,-0.1028073,-0.05895082,0.11398572,0.002208272,-0.052586015,0.04201096,0.025659647,-0.0058491747,-0.074319996,-0.01371365,0.007434883,-0.043615587,0.018440222,0.035928316,-0.074160576,-0.014154353,0.07139535,0.017639324,0.0167788,-0.0578995,-0.034971386,0.027947918,-0.018048847,-0.029512055,0.011855325,-0.02833674,0.01497023,-0.006817545,0.22598445,-0.06927528 +1.14.13.218,"The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. It can also act on phenazine-1-carboxylate, converting it into phenazin-1-ol.",384,1.0,-0.10273127,-0.0002867073,-0.11996482,0.06621364,0.05871946,0.049104996,-0.012372472,0.08256786,0.00370452,0.013892689,0.006277949,-0.016463602,-0.05200395,0.10019321,-0.09013819,0.022287488,-0.106205896,0.06457686,0.012963372,0.057479367,0.06948912,0.08720743,0.022990711,0.056327693,-0.016684592,-0.012347223,0.06376059,0.048246246,0.031532023,-0.045269288,-0.020182533,-0.08516677,0.060557745,-0.009789423,0.04511062,0.067938715,-0.02657197,-0.060381196,0.06425616,-0.032678556,0.05300215,0.031665195,-0.0474955,-0.053777784,0.020196099,0.000524053,-0.008325026,0.054196373,0.034225587,-0.03362698,-0.09096452,-0.012161682,-0.004170868,0.044011008,-0.008230035,0.011920585,-0.05534198,-0.033586197,-0.018311312,0.010351472,0.0117019415,-0.009217666,-0.013867294,0.031334423,-2.5765465e-05,-0.028181728,-0.005618994,-0.01451683,0.02949302,-0.050771642,-0.020212311,-0.053005587,0.039634537,-0.008817791,0.010658742,0.03134722,-0.0006127548,0.01614266,-0.07427922,-0.020890016,0.08404452,-0.04576303,0.008237302,0.03015811,0.038914606,-0.028929211,-0.0100978315,0.036871657,0.0731685,0.044652004,0.036664017,0.0017458915,0.039405063,-0.03237133,-0.08485572,0.017109277,0.032835513,0.028643163,0.039017078,0.00825282,-0.0076377774,0.02684008,0.0059772846,-0.070667565,-0.013854156,0.021070477,0.055108834,-0.017200455,0.019669713,0.034619384,-0.030234622,-0.011633215,-0.018085489,-0.09396634,-0.014475111,0.062215365,0.009802468,-0.027144492,-0.06772691,0.044799134,-0.028777886,-0.061852865,-0.004841859,0.059521183,-0.044640582,-0.020745052,-0.14672384,8.668015e-34,0.046433162,0.03879246,-0.03265744,-0.03004905,0.030119909,0.0018540403,-0.035062786,-0.015828883,0.007213925,-0.10043624,-0.06645607,-0.06279438,0.02800354,0.016392577,-0.011258006,-0.023620639,-0.051545594,-0.05067676,0.0987994,0.022806374,0.039191112,-0.026940415,-0.112342685,0.023165576,0.03087696,0.050910488,0.025768088,0.03402606,-0.042374633,-0.014352498,0.051807687,-0.07437199,-0.08465701,-0.02297325,0.0882166,-0.035501093,-0.05418677,-0.049515113,0.0017366655,0.006008526,-0.039249454,-0.075104974,-0.046355877,0.039045535,0.04567495,-0.0057084775,-0.04183962,0.1296936,0.035431035,0.052666485,0.054000217,-0.053946823,0.064109534,0.03591541,-0.08084864,0.003923284,0.005943599,-0.113669,0.049280584,-0.003215014,0.08193496,-0.0028362602,-0.06301367,0.030491747,-0.04546015,0.026882341,-0.025995592,-0.046752814,0.029030642,0.010634821,-0.0858988,-0.080153234,-0.030697066,0.046418417,-0.001900828,0.007682019,-0.036542043,0.00049222866,0.009369134,0.021539224,-0.019724837,-0.018698221,0.015361151,0.020985166,-0.07228049,-0.009030011,0.007955643,-0.03755606,-0.031172939,-0.03356417,0.10874749,-0.14924383,-0.0070807706,0.06956435,-0.021730633,-1.7762537e-33,0.051822923,-0.046375297,0.07044444,-0.05832889,-0.0138201425,0.026251834,-0.034278724,0.007193802,-0.0013723103,0.015007228,0.011043208,-0.08248733,0.04509245,0.0098879635,0.03714361,0.046701647,0.04274383,0.032990057,-0.023921993,-0.017256988,-0.024714729,0.04762843,-0.017996637,-0.0024415397,0.0024429536,0.08293074,-0.0026183298,0.08125825,0.04076731,0.123480774,-0.06717351,0.053550605,-0.041640557,-0.008190609,-0.009667293,0.0792082,-0.01940866,-0.036869776,0.030931462,-0.04283243,0.0757142,0.001755724,-0.033453763,0.0714982,0.007821195,0.0784964,0.004366119,0.0039300635,-0.02827874,-0.0893836,0.036191832,0.15662156,0.03892898,0.035078015,0.008371174,-0.00031056823,-0.007855046,-0.03520927,-0.003143622,-0.01849051,0.040344536,-0.13443984,0.0017099857,0.020013804,0.02321034,0.026998222,0.02905721,0.061013285,0.060829967,-0.046432316,0.05775479,0.03851365,0.06391414,0.065874115,-0.14735611,0.049998578,-0.050942928,-0.09576837,0.0077916244,0.036437042,0.04569917,-0.055982437,0.029672265,-0.07111668,-0.011537458,-0.052279226,0.054799184,0.056650188,-0.037326507,0.0082874475,0.015100221,0.026992965,0.012246816,0.07817782,0.04283419,-3.630677e-08,0.034986034,-0.07791196,0.06256737,-0.04260442,0.031351075,0.024842907,-0.04111932,-0.02660563,0.006196171,-0.04345514,-0.06535352,0.032418128,-0.047811575,0.02190115,0.06478638,0.04994464,-0.10147512,0.062629744,0.0016258389,0.008672142,-0.05226555,-0.0037384767,-0.13538896,0.017607879,0.0019224208,-0.030964408,-0.0043103984,0.03276214,-0.003913263,-0.010451644,0.034727745,0.0033434108,0.0060465094,-0.006260701,-0.14098813,0.03452739,-0.0020464675,-0.10689177,-0.08702699,-0.07513387,0.032035973,0.002204669,-0.045376968,0.03459851,-0.03211828,0.020073134,0.014782403,-0.030867623,-0.0017931901,-0.06587921,0.10806851,-0.0072039906,-0.015461342,-0.05255555,-0.10733738,-0.03070933,0.00965658,-0.0047207344,-0.050396144,0.023466732,-0.040899944,0.046050597,0.2000451,0.036180995 +1.14.13.219,"The enzyme, characterized from the bacterium Corynebacterium glutamicum, is a single-component hydroxylase. The enzyme has no activity with NADH. cf. EC 1.14.13.220, resorcinol 4-hydroxylase (NADH), and EC 1.14.14.27, resorcinol 4-hydroxylase (FADH2).",384,0.99999994,-0.035718385,-0.06769445,-0.087386265,-0.039494183,-0.006642552,0.046113744,-0.08330734,0.03646617,0.019579055,-0.024535496,-0.002285749,-0.060046215,-0.03123269,0.05824498,-0.04291015,0.04624877,-0.05554221,-0.07554783,0.015454735,-0.066545814,0.04904043,0.04973596,0.010461593,0.011388957,0.07968393,-0.021398358,0.021805344,-0.006467895,-0.022088148,-0.04144023,0.010669004,-0.028333025,-0.04749161,0.028741555,0.07526008,0.10137931,-0.055425264,-0.025667772,0.039524727,0.034177292,0.017001044,0.0007177238,-0.038067978,-0.012693125,-0.067273505,0.0188452,-0.00084592024,0.037056267,0.048608705,0.0186441,-0.02003546,-0.049861223,-0.07619764,0.07604147,0.11235797,-0.021568358,-0.023877306,-0.0076534464,-0.029924817,-0.005248071,0.0044331322,-0.058483068,-0.014821344,0.0228308,0.006013075,-0.01230588,0.01228769,-0.093213275,0.010994823,-0.07964127,-0.101078466,-0.05948896,0.062009748,0.026949354,-0.040106107,-0.05286434,-0.07104421,-0.0076970775,0.11009918,0.00640334,0.033926148,0.0065147253,-0.04976297,0.08465149,0.031144943,-0.035783105,-0.008383296,-0.0024574825,0.061499517,-0.045326665,0.035786346,-0.013878805,-0.03299412,-0.039552122,-0.08054676,0.0125076445,0.039425667,-0.05410293,-0.006825123,-0.0080019785,-0.01521743,0.058415413,0.0143190315,-0.08720075,-0.11913812,0.033406463,-0.016810736,0.1371042,-0.02302589,0.018122988,-0.0056798034,0.0030144409,0.03961897,-0.030817382,-0.04567252,0.0071670273,0.041889314,-0.07825605,-0.097260185,-0.06564009,-0.016354276,0.00054695865,0.11205722,0.04861048,0.0077812714,0.0070762546,-0.07426549,-3.9013427e-34,0.08877316,0.027164614,0.0065309843,-0.07021437,0.037618704,0.013747702,-0.05570569,0.097164154,-0.030201111,-0.07439993,-0.009230279,-0.028451322,0.0063882982,-0.0067181936,0.0009603008,0.05949413,0.0063153156,-0.017332358,0.013288961,0.01348697,0.013216873,0.06466619,0.010005262,0.043616537,-0.055803787,0.007180288,0.0009871789,0.045618184,-0.0092510665,0.0005242416,-0.018793153,-0.09272974,-0.11059353,-0.0012648597,0.0076560457,0.0010728735,-0.08092324,-0.039891496,-0.00016742476,0.048407324,-0.06662773,0.06642376,0.07046723,-0.11636642,0.02881672,-0.07314544,-0.018391924,0.10713461,0.013340701,0.066741094,0.0411802,-0.035273727,0.13918972,-0.055836137,-0.051149186,0.07214187,-0.017206414,0.03809334,0.010165387,0.051797215,0.028338706,0.035405014,-0.0680564,0.040239856,-0.06063521,0.041983265,-0.10020615,-0.015115773,0.03590588,0.1257082,0.007938864,0.023487397,0.07679452,-0.0008154886,0.035334054,-0.07798388,-0.0012084071,-0.030678466,-0.020542515,0.046180554,-0.01698649,-0.053397167,0.0228398,0.0120001715,-0.07042042,0.00599024,0.011581315,-0.025649613,-0.041598413,0.033098657,-0.0014862774,-0.059914213,-0.01641952,0.0070782765,0.038769484,-1.25189845e-33,0.1267439,-0.039717194,0.054830357,-0.11485466,0.047308445,0.08824635,0.08688556,-0.020535436,0.016978638,-0.024596982,0.099640265,0.08890872,0.005882686,-0.013087643,0.025954532,0.031102829,-0.04482916,0.08244413,-0.002445269,-0.00057289156,0.025715262,0.097558945,0.002277505,-0.029418005,0.05188936,-0.062467847,-0.021405945,0.09667982,0.01921496,0.05070016,-0.004972882,0.025248634,-0.009323037,-0.042086497,-0.025645414,0.034687333,-0.023983154,-0.030283464,-0.012122305,0.024849653,0.050189946,0.026547717,-0.047334258,0.09603108,0.06885694,0.05908398,-0.08952764,0.0012809845,-0.0036780676,-0.05026835,-0.022192437,0.012566882,-0.037547316,-0.014326095,0.019538425,0.067378044,-0.024810137,0.012231926,-0.0024122049,-0.032896563,-0.03861661,-0.1022458,-0.0066408007,0.02169212,0.05800095,0.0102131115,-0.045293596,0.009028298,0.052366555,0.025797956,0.079709336,-0.0001733346,-0.011384654,0.035720274,7.2162846e-05,-0.012145962,-0.057305448,-0.026033247,-0.060730815,-0.00013982381,0.060416892,-0.0029969518,-0.02579764,-0.025879472,-0.007876076,-0.028048914,0.03671805,0.07984259,-0.051136438,0.038399406,-0.044981904,0.049917422,-0.047192913,0.057882335,0.036124863,-3.889656e-08,0.010439938,-0.030961001,0.03834441,-0.05373865,0.03062633,0.073150046,0.030669842,0.030777663,0.028237678,-0.018164372,-0.022433612,0.088211566,-0.027562344,0.044232503,-0.0035969699,0.012428375,-0.10227982,-0.015228863,-0.070274256,0.007844238,-0.02536154,-0.018834557,-0.09231839,0.06684859,-0.055493847,-0.038436245,-0.0031765574,0.027323555,-0.07234158,-0.0521544,0.023251725,0.011262738,0.041343406,-0.054897975,-0.09663446,0.053044956,-0.005463766,0.047174215,-0.01147175,0.04821129,0.053620707,-0.037337415,-0.039627455,0.045546968,0.026088275,0.02970276,-0.0100599555,-0.02458183,-0.0032138068,0.046890657,0.09293405,0.013743417,-0.04747967,-0.044933427,-0.07398646,-0.0018224738,-0.049252003,-0.08110087,-0.034936707,-0.09002511,0.15440437,0.022089113,0.19914241,-0.0326807 +1.14.13.220,"The enzyme, characterized from the bacterium Rhodococcus jostii RHA1, is a single-component hydroxylase. The enzyme has no activity with NADPH. cf. EC 1.14.13.219, resorcinol 4-hydroxylase (NADPH), and EC 1.14.14.27, resorcinol 4-hydroxylase (FADH2).",384,1.0,-0.025697665,-0.045228787,-0.0791437,-0.011096653,0.05806743,0.04478035,-0.092772454,0.027212251,0.02534567,-0.05493934,-0.03404016,-0.058220092,-0.007191223,0.082310446,-0.05189534,0.002783291,-0.06830974,-0.04829551,0.004215089,0.003682528,0.07550496,0.020544952,0.009880057,0.0009708549,0.08467201,-0.030070907,0.025863772,-0.014944979,-0.085943855,-0.03347279,0.018013667,-0.04568609,-0.015805213,-0.023379177,0.055445038,0.09327003,-0.0067083477,0.0063235722,0.008806754,0.040215626,-0.00057545875,-0.04104457,-0.008521208,-0.033733074,-0.024296816,-0.014346686,-0.029459115,0.045001525,0.040065717,0.038275607,-0.07763519,-0.026757492,-0.06315093,0.08537687,0.10702292,-0.031243844,-0.018320879,0.013853531,-0.052296184,-0.023541693,0.029024247,-0.07060848,-0.013356941,0.015226553,-0.0012797719,-0.075852074,0.029811267,-0.094132185,0.006073901,-0.053296275,-0.101878986,-0.03091419,0.04880092,-0.029830879,0.011041538,-0.003471976,-0.028351229,-0.0152457,0.098855026,0.0077660433,0.03096988,0.0068675578,-0.047351256,0.0652144,0.031072926,0.01974958,0.012024282,-0.032067128,0.024593232,-0.001994419,0.024925884,-0.007857332,-0.046612848,-0.046362832,-0.06472441,-0.013915029,0.024982322,-0.007980581,0.012306044,-0.021259747,-0.024425441,0.04164509,0.06583379,-0.11025027,-0.118451774,0.02016835,-0.051172268,0.1371191,-0.018319406,-0.006299004,0.011942636,-0.026101757,0.04047128,-0.006752774,-0.044676047,0.07529621,-0.015031186,-0.067638054,-0.13109979,-0.056835454,-0.009826255,-0.049084194,0.094602406,0.015741657,0.014987315,-0.02222082,-0.11903098,1.7475355e-36,0.09410049,0.023199566,-0.05365687,-0.03508567,0.009874177,0.02160715,-0.06440749,0.11937088,-0.045681827,-0.09104101,0.046762664,0.005391771,0.007545479,-0.013254319,0.009026644,0.03359959,0.031487536,-0.040600106,-0.007985485,-0.009371089,0.02792196,0.05958476,-0.015015542,-0.0036576374,-0.04153356,-0.011094279,-0.017742122,0.008950223,-0.06225592,0.020579224,0.04622276,-0.07920743,-0.073146574,0.034201942,0.038368665,0.012650489,-0.06481685,-0.042543206,-0.010689248,-0.012090414,-0.048870027,0.0657227,0.061078466,-0.111175224,0.036355585,-0.09401408,-0.055011958,0.11100432,0.005654011,0.096135356,0.0039469376,3.6346784e-05,0.12114779,-0.044931777,-0.032306414,0.012910765,-0.027068855,0.020859893,-0.00057542656,0.044275995,0.00080472435,0.06515017,-0.052313082,0.056754746,-0.026896948,0.0026170907,-0.047834132,-0.037979726,0.025192266,0.1054119,0.020242507,0.05945043,0.07957717,-0.00028265276,0.023972748,-0.06905786,0.03738051,-0.004824277,0.012016887,0.05875996,0.0068006716,-0.02435691,0.019541778,0.005838641,-0.06388833,0.03372215,0.05330996,-0.01515349,-0.06243515,0.043371215,0.03479804,-0.08903959,-0.021586685,-0.015130531,0.061672106,-1.2281607e-33,0.12098648,-0.072766215,0.0720476,-0.100133486,-0.00063272077,0.099172965,0.067342184,-0.011375574,-0.0034041195,-0.0667287,0.11384518,0.03727522,0.016767332,0.028225755,0.080969006,-0.013980546,-0.024134882,0.0006704793,0.023594031,0.046032116,0.030297281,0.093794465,0.00515292,-0.020004703,0.042561866,-0.07346934,0.011670564,0.09033439,-0.043385845,0.02219332,-0.03195338,0.0016813038,-0.036415584,-0.058879804,-0.029835979,0.021211121,-0.040600102,-0.02936435,0.025193496,0.0527027,0.10060419,0.0017390946,-0.08150373,0.04077626,0.04831302,0.030231914,-0.09455561,0.04951414,0.03978026,-0.068718076,-0.0043581505,0.021466756,-0.03768789,-0.02103708,0.06467023,0.07396936,-0.01992628,0.049714413,-0.019713484,-0.017044643,-0.062040422,-0.03640758,-0.015654631,0.05583266,0.06861025,0.04225957,0.011446097,-0.0040256614,0.038267557,-0.008681424,0.11383044,0.0073015974,0.02607784,0.045676652,-0.015223033,-0.101424985,-0.10339183,0.0009972231,-0.052284963,0.017862117,0.09354796,0.0016221768,-0.00201923,-0.06342844,0.03530261,-0.02284358,0.031784624,0.06130895,-0.05144514,0.003039751,-0.002554088,0.07629462,-0.038432553,0.03994479,0.0645058,-3.5795242e-08,0.031026384,-0.06075104,0.06193425,-0.056339443,0.03421825,0.03977791,0.057778478,-0.018955052,-0.012153232,0.047199164,0.007848885,0.109028816,-0.003812715,-0.03037792,0.023154449,-0.020057747,-0.09608419,0.022889536,-0.058052782,0.033638407,0.013290063,-0.017326707,-0.08843707,0.04360958,-0.028362142,-0.030240599,0.019406913,-0.04291973,-0.02193606,-0.089619115,0.0044133137,-0.010144217,0.08866338,-0.03261542,-0.124837786,0.010069629,-0.0070057428,0.05169009,-0.06785606,0.0411687,0.072939575,-0.021377191,-0.02775279,0.019635648,0.023225307,0.037442487,-0.023410063,-0.05653672,0.0013919935,-0.0033133507,0.016958624,0.036814936,0.00870439,-0.05874013,-0.08382492,0.01575105,-0.012031515,-0.045712493,-0.029342717,-0.021075098,0.11823018,0.060959555,0.14444178,-0.035547856 +1.14.13.221,"This enzyme, found in several bacterial pathogens, is involved in degradation of the host cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol. The products are exclusively in the (25R) conformation. The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.13.141, cholest-4-en-3-one 26-monooxygenase. The enzyme can receive electrons from ferredoxin reductase in vitro, its natural electron donor is not known yet.",384,0.99999994,-0.058680017,-0.0080733625,-0.11241568,0.032040514,-0.012003886,0.032275807,-0.10440786,0.02705668,-0.040618222,-0.068115115,0.00043770912,-0.027168233,-0.015113747,0.0021172126,-0.057822075,0.022945633,-0.10212293,-0.021622444,0.026081271,0.017627232,-0.063682534,-0.03207725,-0.03470795,-0.061338637,-0.0015983356,0.0103776725,0.018973906,-0.07559191,-0.09298493,-0.06854403,0.050426498,-0.006041748,0.081360176,-0.036275823,-0.01432502,0.03872846,-0.022437597,-0.043145295,0.08591117,-0.018177172,0.010567165,-0.024467364,0.030635392,-0.04046742,-0.0026194665,-0.06801481,-0.0010442266,0.05145831,0.037101805,0.032429837,-0.028182264,-0.031349644,-0.030812915,0.034649808,0.071778215,0.0028180422,-0.016215725,-0.08238193,-0.0024664444,0.009383411,0.047551516,-0.029280998,-0.005815105,-0.0006019401,-0.070197135,-0.14628267,0.021569578,-0.06455781,-0.013049633,-0.06584734,-0.064060956,-0.06787664,-0.03941035,-0.021615775,-0.008449481,0.06758685,-0.01726372,-0.089256786,0.050550513,0.0007577619,-0.0010277452,-0.03364368,0.03681555,0.13134886,0.077526845,0.005447763,-0.020699147,0.00011993347,-0.05474091,0.050837036,-0.00047220816,-0.0050860955,-0.04169571,0.00083983736,-0.056499366,-0.014592853,0.07876931,0.02871117,0.0014518579,-0.0029880228,-0.0068486654,0.050799638,-0.003398648,-0.115148984,-0.0519706,-0.014991282,0.029613163,0.12092454,0.042527273,-0.0039469693,0.0058809873,-0.0072928816,0.037862204,-0.05448039,0.01897423,0.19653311,-0.0070735128,-0.085522614,-0.06986163,0.04542343,0.048818383,0.018470932,0.024956556,0.027964965,-0.009472598,-0.006944749,-0.01919697,6.43932e-34,0.019223828,-0.014735741,-0.0015047536,0.02366556,0.034034733,0.066304274,-0.060044996,-0.007209407,0.020639155,-0.07351949,-0.00026092978,-0.08146645,0.109300464,-0.025700795,-0.04706524,0.00075560494,-0.033817496,-0.058203638,0.034505196,0.0061672283,0.023004118,0.025774468,-0.06950893,-0.006906444,0.0047938847,0.015247309,-0.012648979,0.068749495,0.0024730882,0.016207995,0.020195268,-0.027354963,-0.093628645,-0.0024894758,0.05793986,0.0054935417,-0.04899587,-0.016401827,-0.053214237,0.08276188,0.064002685,-0.0030332226,-0.024647161,-0.05565471,0.0983329,-0.0047287894,0.02081948,0.11041046,0.022431472,0.07188003,0.02400027,-0.002126465,0.052918896,-0.004275847,0.013029059,0.10473598,0.00671508,0.031187057,0.03497055,0.052467495,0.08397548,0.051883925,-0.056761023,0.03497835,0.006725791,0.008774176,-0.0013243068,-0.07372562,-0.09563525,0.10654494,-0.027392285,0.059001032,0.014984269,-0.028382204,-0.0088204965,0.015507306,-0.06500029,0.030834751,0.081828296,-0.1097874,0.00054877915,0.02844725,0.0044015828,-0.078485765,-0.023208965,0.0145106595,-0.08835845,-0.04825898,-0.018935231,0.036007185,0.045145046,-0.110168934,-0.14499125,-0.013007863,-0.029359652,-2.5117679e-33,0.044355825,-0.07914008,0.01754284,-0.09452524,-0.009605978,0.075443566,0.061039627,0.044750843,0.067635305,-0.024432996,0.068797044,0.048673067,0.041241553,-0.033829123,0.08289825,0.082351714,-0.08225449,0.013033408,-0.010587652,-0.0058719427,-0.002286378,0.0752827,0.005206256,0.09061835,0.040112182,0.034076765,-0.051387563,-0.031834237,0.13441613,0.043131407,-0.03379425,-0.053721968,-0.028435754,-0.05083711,-0.042747624,0.0975014,-0.051069405,0.014609755,0.05280667,-0.00034782162,-0.03553313,-0.0023690576,0.0062812697,-0.0037133605,0.0612267,0.042485625,-0.08970062,0.04251132,0.053032044,-0.032730345,0.008133988,-0.014415284,0.021011546,0.03491195,-0.027956191,0.079283334,0.07908597,-0.003881618,0.05933422,-0.07223023,-0.066930614,-0.03090701,0.042491514,0.032878563,-0.023381598,0.0310853,-0.018989796,0.063778624,0.038800616,-0.01654284,0.019206217,0.056073435,-0.041095685,0.030538306,-0.017039146,-0.04998688,-0.0046705673,-0.010280987,-0.029201789,-0.005212586,0.018432407,0.0245935,0.025224434,-0.06402208,0.028643942,-0.12591633,0.01987302,0.029094178,0.029982999,0.024613716,-0.020488203,-0.016998284,-0.090490244,0.018658105,0.027618635,-3.8504474e-08,0.006314237,-0.06730663,0.0022380848,-0.015142126,-0.0037779377,0.027825505,0.002022133,-0.006188473,0.04376427,-0.025672425,-0.010865471,0.16493808,0.03968765,0.004893543,0.00070232834,0.030630784,-0.038792253,-0.035285734,-0.026010899,-0.01855254,-0.0034374509,-0.03671577,-0.0243848,0.06851343,-0.029709162,-0.029438851,-0.004560398,0.034443513,-0.009877735,-0.06357094,-0.04753816,0.05240214,0.03160952,-0.0022438478,-0.04948679,0.010442168,-0.06283832,-0.072236955,-0.0110487845,0.092526786,0.03368589,-0.027692618,-0.038223702,-0.031519216,4.1557145e-05,-0.015840368,-0.055547208,0.028800668,0.016157636,0.003916655,-0.016073804,0.024481438,-0.011704406,0.0005954009,-0.05023607,0.08031922,-0.032917943,-0.07105537,0.05990737,-0.04328349,0.0198546,0.04687818,0.21370408,0.03618322 +1.14.14.27,"The enzyme, characterized from the bacterium Rhizobium sp. strain MTP-10005, uses FADH2 as a substrate rather than a cofactor. FADH2 is provided by a dedicated EC 1.5.1.36, flavin reductase (NADH). The enzyme participates in the degradation of gamma-resorcylate and resorcinol. cf. EC 1.14.13.220, resorcinol 4-hydroxylase (NADH), and EC 1.14.13.219, resorcinol 4-hydroxylase (NADPH).",384,1.0,-0.056337338,-0.018004617,-0.112803444,-0.029238312,0.12993068,0.013221678,-0.072219305,0.071952745,-0.0017905411,-0.06926841,-0.005062927,-0.04511571,-0.043623656,0.046169523,-0.0647616,-0.018058497,-0.026772486,-0.023963898,0.029804511,-0.040242948,0.04705019,0.008597772,-0.0029123155,0.0040699188,0.046777073,-0.016027888,0.014215113,-0.008752915,-0.04319397,-0.06265718,0.052529003,-0.019289585,-0.024314418,-0.02014616,0.015193749,0.14993474,-0.005907068,-0.030562691,0.0009595726,0.003021,0.00317168,-0.024658034,0.073488146,-0.03901894,0.044289704,0.023825614,-0.00091578485,0.06025246,0.021841506,0.015731832,-0.050410803,0.005103868,-0.037252136,0.06303482,0.06314178,0.032006703,-0.018188449,-0.059445173,-0.059347123,0.009898002,0.00849777,-0.028742885,-0.04139141,-0.0039037503,-0.016442582,-0.019922309,0.008939875,-0.11190641,0.03905654,0.023455385,-0.10086469,0.000677874,0.0073273242,-0.03766388,-0.0056397296,-0.012350158,-0.05758881,0.0005481403,0.053258836,0.017016206,0.02327309,0.0043471484,0.05581097,0.03561596,0.037150834,-0.027723566,0.03182669,-0.03372929,0.017245771,0.039102096,0.06043296,0.046315525,0.02446481,0.0029074166,-0.1355623,0.061119046,0.014195218,0.015800664,0.024785548,-0.008775965,-0.0140609415,0.023008065,0.0123184845,-0.047688834,-0.15988478,-0.051195305,-0.04511239,0.17704761,-0.015351503,0.00014682006,0.0601116,0.002838425,0.04573255,-0.045161802,0.02052537,0.07033233,-0.029630316,-0.09655952,-0.09949076,-0.021749958,-0.05110963,0.019467797,0.053409602,0.016588913,0.028426487,-0.026987037,-0.14453402,1.579368e-33,0.059934422,0.0332582,-0.035772122,-0.05470472,-0.0003080715,-0.004240376,-0.094366565,0.044598024,-0.008038291,-0.10534727,0.06655572,-0.007627845,0.011784442,-0.0441981,-0.021479981,-0.03601178,0.0019261086,0.0042315014,0.016780296,-0.013241034,0.009541195,0.054231763,0.026695905,0.0026876144,0.013574836,0.040404256,-0.009210839,0.05966103,-0.056988697,0.03881934,0.04776109,-0.06367529,-0.09582937,0.023020012,0.026482088,0.0034474242,-0.09279343,-0.021556087,-0.03587558,0.04303622,0.022738801,0.06019433,0.012733547,-0.011440542,0.064413846,-0.10976372,0.007609986,0.126145,0.016320717,0.05884109,0.035652746,-0.016786434,0.10011959,0.008184438,-0.06633238,0.032759704,-0.041919127,-0.007438642,0.01644992,0.0295064,0.02314945,0.05753748,-0.057951156,0.08413695,-0.030055718,0.0005610342,0.015338828,-0.09283541,0.016118852,0.11887573,0.017688038,0.022064917,0.11340082,0.027225694,0.05725525,-0.07307223,-0.0041095144,0.009359081,0.013715946,0.06505943,-0.03303144,-0.010632534,-0.017231712,-0.033935666,-0.04210392,-0.0061321263,0.03339121,-0.052830145,0.018058037,0.026937017,0.06749686,-0.117984556,-0.004957081,-0.015637865,0.04978712,-1.0653428e-33,0.121980175,-0.05563062,0.026803195,-0.06427864,-0.016970674,0.038291294,0.07692813,-0.019479025,0.021670366,-0.047673035,0.052266866,0.041166704,0.012921332,0.0028222923,0.08980388,-0.04435346,-0.017621513,0.013426873,0.021016836,-0.030803502,0.04591742,0.11328851,0.006802012,-0.017771216,0.021432882,-0.012495656,-0.05008301,0.067557834,0.06389108,-0.009524646,-0.06668827,0.025406703,-0.039368585,-0.044412427,-0.045580417,-0.0030138788,-0.058600187,0.031099353,-0.0071580755,0.033741888,0.093402095,0.083258405,-0.06087432,0.0076330304,0.041614193,0.067072846,-0.10171378,0.030983334,0.06117725,-0.10520722,-0.006672153,-0.00478021,-0.05373825,-0.034062296,0.006683914,0.066033565,-0.04751416,0.06845749,-0.017072486,0.014045686,-0.036474776,-0.093930736,0.0041980008,0.050388858,0.08805037,0.055097945,0.040619846,0.04847895,0.00045001382,0.076057315,0.053272866,0.022155961,0.053831358,0.07824029,-0.012110019,-0.03797995,-0.11453798,0.0670636,-0.034775678,0.026508989,0.0734142,0.006176112,-0.0017232634,-0.058047604,-0.0016939067,-0.050518,0.016804349,0.07889738,-0.02778149,0.001985003,-0.0025969993,-0.014097269,-0.016818106,0.018514244,0.057070352,-3.864177e-08,-0.0020162095,-0.0580308,0.046227694,-0.06662724,0.04994184,0.0668826,0.03557019,0.010456902,0.048858434,-0.019785501,-0.034389492,0.09453557,0.04805274,-0.0005391364,-0.011953646,0.024232987,-0.03388877,-0.024563733,-0.05079622,0.005422471,-0.061169736,-0.020480307,-0.07840725,0.037590533,-0.030430594,-0.0014616216,0.00991749,0.016617067,-0.08070469,-0.06278965,0.007976374,0.014956295,0.08065128,-0.0030426162,-0.12449104,-0.015201556,-0.022184718,-0.00994508,-0.02850994,0.07074507,0.009797808,0.0064697796,-0.034236453,0.023480676,0.021155525,-0.014646172,-0.0061142454,-0.039039306,-0.063586436,-0.036192674,0.024320286,-0.0073539848,-0.037810575,-0.090673074,-0.06477748,-0.029612083,-0.0017911936,-0.0746136,-0.049275782,-0.0372003,0.10401123,0.064353205,0.16049574,-0.04537466 +1.14.14.28,"The enzyme, characterized from the bacterium Geobacillus thermodenitrificans NG80-2, is capable of converting alkanes ranging from C15 to C36 into their corresponding primary alcohols [1,2]. The FMNH2 cofactor is provided by an FMN reductase [3].",384,1.0,-0.012988214,0.0007325333,-0.13784496,-0.01991172,0.048661705,0.013970322,-0.11265946,0.0119935265,-0.025222424,-0.0813469,-0.014521998,-0.13888057,-0.12570603,0.056856487,-0.06375252,-0.03847802,-0.071818806,-0.029723601,0.028660582,-0.033355623,0.004616943,0.044574384,0.03126296,-0.04927687,-0.021724084,-0.0014569054,0.012314779,-0.026314266,-0.00030711901,-0.03066968,0.025094489,-0.040319327,-0.016145444,-0.05760699,0.055509295,0.013583573,-0.028288674,0.036301043,0.072707124,0.06359339,0.0609274,-0.022953656,0.044794288,-0.024868727,0.0076835733,0.034410052,-0.03173742,0.03629288,0.015160254,-0.02364709,-0.039992657,-0.018112885,-0.08268567,0.09789338,0.10462034,-0.018156923,-0.03516532,-0.011165605,-0.00043088535,0.08421203,0.049952284,0.046300128,0.000750754,-0.037755188,0.08120302,-0.03749994,0.046664726,-0.08040855,-0.02599841,0.0095853405,-0.10922096,-0.033676796,0.022324922,-0.035398327,0.03963593,0.03354577,-0.056412082,0.027815774,0.06946174,0.038905066,0.03059347,0.01783179,0.076682664,0.07396235,0.012520826,-0.06992228,-0.041280612,0.006741696,0.038606152,0.06298536,-0.033081785,-0.0013672084,0.039127063,-0.09247805,-0.043182794,0.04659516,0.026767964,0.10751872,0.07274538,-0.017798465,-0.0041300505,0.0059427377,-0.046139237,-0.117613174,-0.14056799,0.017314412,0.0042441306,0.11077591,0.12741809,0.029532814,-0.037034515,0.08194863,0.017050607,-0.10563809,-0.016239848,0.024720494,-0.04143357,-0.06478975,0.0031306131,0.041322004,-0.075509,0.009735536,0.05276191,0.088347726,-0.046752535,0.016092189,-0.11376524,2.801469e-33,0.02946375,0.06471513,0.044968788,-0.017005343,-0.030554604,-0.07077313,-0.08928601,-0.056613293,-0.0008167947,-0.073092505,-0.041693643,0.0039050719,-0.028636798,0.008698964,-0.0045764423,-0.042639773,0.0070359474,-0.053855654,0.008084447,0.01010972,0.043700468,0.07783177,-0.007859636,0.036664654,0.08388322,0.042591397,0.0032020486,-0.00019554909,-0.03886447,0.0013225228,-0.06305667,-0.10746844,-0.10077174,0.006690448,0.023372408,-0.044629257,-0.03402368,-0.021325503,-0.01091422,-0.013828465,0.105915464,0.04079803,0.027019266,0.036240738,0.03732729,0.08304884,-0.049147036,0.07706979,0.023182388,0.096092515,-0.04002174,-0.010390728,-0.009536072,0.007157777,-0.079534456,0.01050256,0.0106893545,0.011651737,0.06548165,0.024825005,-0.03007514,0.05239687,-0.006005721,0.0337869,0.0030525587,-0.03372107,-0.020485083,-0.039507963,0.010351817,0.020248767,-0.07991515,0.051445436,0.09636052,-0.0111012375,-0.005426092,-0.045333434,-0.011516848,-0.048671275,0.038119912,-0.021416543,0.004646459,-0.0075282846,0.010942681,-0.07780131,-0.054468155,-0.08519031,-0.028749984,-0.0721538,-0.023696272,0.066995196,0.0017504451,-0.09558741,-0.011464609,0.0025529875,0.0033994126,-3.9931826e-33,0.09694249,-0.11332447,0.03265724,-0.09038659,-0.06877461,0.030745542,0.054020774,-0.025391256,-0.01662807,0.016428487,0.08181161,0.012538723,0.07298371,0.0083129285,-0.042782225,-0.04137357,0.0041578924,0.09043855,0.07139546,-0.010775829,0.017700862,0.032828283,-0.002824605,0.0029255752,-0.007701227,0.07029755,0.07135367,0.096441396,0.05480162,0.017236922,-0.041006237,0.017799277,-0.015884753,-0.032765538,-0.05636248,-0.013954663,0.022623999,-0.020498736,-0.04750097,0.0031079813,0.049460202,0.029608902,-0.07641969,0.03776643,-0.033733517,0.11270022,-0.03252341,-0.010770275,0.05867975,-0.0650702,0.06512735,0.03219993,-0.089369275,0.017359605,-0.023766957,0.018418727,0.03527482,-0.021763049,0.0028430596,-0.00785324,-0.061953798,-0.012572185,0.07307263,-0.038055107,0.027948692,0.045076184,0.017508592,0.08619662,0.0054347725,0.025455296,0.0642873,0.011555481,0.06826886,0.02623537,-0.041798227,-0.06473769,0.01694864,0.01663689,0.010601089,-0.0548038,0.03476553,-0.017550493,0.024640067,-0.025970357,0.06779863,-0.05526723,0.11419122,0.07208413,-0.0054687713,0.04767989,0.019149698,0.036724333,-0.026659308,0.053589765,-0.0015056452,-3.681716e-08,-0.026355818,-0.025044858,0.061404046,0.03005209,-0.016202886,0.06596325,0.0021152084,-0.0110201,-0.0155689195,-0.028870853,-0.01662302,0.033600725,0.019707164,-0.005808624,0.036223512,-0.032606523,-0.0489065,0.030360574,0.0029123144,-0.013145684,-0.07267152,-0.002314966,-0.030478656,-0.017714322,-0.055752233,-0.039087337,0.028419638,0.0371349,0.031851474,-0.0388745,-0.085139625,0.050725088,-0.02419434,-0.013840386,-0.123362,-0.08426311,-0.049199276,-0.03801649,-0.06741797,-0.007349402,0.009505719,-0.0014419003,-0.10503487,0.030484414,-0.0071008564,-0.043886628,0.003196146,0.03639894,0.02222633,0.035050716,0.060359374,0.033065397,-0.032757107,-0.021843081,-0.09631134,-0.01740521,-0.06689469,0.007506792,-0.068696804,-0.06288202,0.06866809,-0.027316114,0.1455294,0.013317715 +1.14.14.29,"A P-450 (heme-thiolate) protein. Unlike EC 1.14.14.26, 24-hydroxycholesterol 7alpha-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent [2]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.",384,1.0,-0.08875409,0.024744865,-0.0633871,-0.022728082,0.07027322,0.020444598,-0.03939164,0.12320921,-0.014566883,-0.04027481,-0.051474243,0.014964673,-0.07696548,0.015183311,0.0036804802,0.007276148,-0.050248224,-0.01964302,0.032383006,-0.05998317,0.013475371,0.016619751,0.026441677,0.025175823,-0.023782957,0.036842763,0.06382154,0.063692264,-0.09671118,-0.089556225,-0.025637936,-0.034277473,0.0017429041,-0.0044253413,-0.015111145,0.11213666,-0.07508101,-0.055024244,-0.014004278,-0.020564003,0.1017879,-0.08579947,-0.05046281,0.0060232324,-0.034082312,-0.050352514,-0.002732016,0.043658648,0.015817424,0.04993333,-0.025782784,-0.043888807,-0.04109754,0.023015266,0.020343622,-0.015939055,0.060543533,-0.00870438,-0.048274443,-0.044756077,-0.047109876,-0.00636504,-0.006611504,0.0088727465,-0.030014683,-0.059772912,0.017525926,-0.08831974,-0.034740396,-0.09557839,-0.017727027,-0.04815864,-5.920409e-05,0.05947705,-0.051168747,0.07844498,-0.05400817,-0.047271185,0.03848751,-0.009650506,0.032425486,-0.006554351,-0.05713069,0.08475333,0.08997077,-0.018814372,-0.05712877,0.045418937,-0.043336686,-0.025921943,0.031179242,-0.011071218,-0.0014460194,0.05013389,-0.110667735,0.044699863,0.0063291597,-0.0098122135,-0.055991184,0.0014077771,0.029762367,0.10214516,-0.026159927,-0.065658696,-0.089394376,-0.009055968,-0.007652239,0.07200177,-0.006915614,-0.05023617,-0.019832961,-0.049175527,0.0655921,-0.02292215,0.04130682,0.10349613,-0.040470574,-0.030324413,-0.07711158,-0.030655863,-0.013200853,-0.001355921,0.05446595,0.04758003,-0.028355734,-0.018168693,-0.100281425,2.1698103e-33,0.06586857,0.0020931317,0.0070096464,0.038261462,-0.042252123,0.07342393,-0.066373445,0.051922053,-0.009882191,-0.051897112,-0.008872665,-0.094545245,0.09000684,-0.0044671474,-0.04348998,-0.051741786,-0.051414598,0.079566196,0.027469827,0.029232156,-0.012684816,0.034560397,-0.067291245,0.029516667,-0.0033341262,0.06103262,-0.03710032,0.016920807,0.004004113,0.030225702,-0.043160476,-0.057591278,-0.0422147,-0.042743884,0.018271498,0.0016502737,-0.051953092,0.004849318,-0.06413336,0.042153876,-0.013514109,-0.009489194,0.0017795976,-0.075276166,0.06236925,-0.0036570278,-0.05492302,0.07399562,0.010452621,0.035938106,0.032399215,-0.04743164,0.09897394,0.025548583,-0.024054408,0.059360854,-0.024081644,0.056478776,0.029310541,0.031453826,0.14718267,0.10014795,-0.06945668,0.013966126,-0.04043972,0.066529274,-0.019424327,-0.056183413,-0.048403747,0.17543681,0.04062414,0.07432444,0.056100164,-0.010992353,0.0031362856,-0.013438679,-0.0135723995,0.09355648,0.055771895,-0.0002874943,0.03846524,-0.037133332,-0.02207151,-0.05443504,-0.009221549,0.024570066,0.02878956,-0.0015018436,0.007100845,0.02510287,0.1240796,-0.13359307,-0.040272214,-0.03671048,-0.054846402,-1.8641794e-33,0.058327224,-0.05588321,0.020937946,-0.10582197,0.00018768814,0.07219654,0.0789219,-0.0170175,-0.034128465,-0.0023348504,0.08644184,0.011277577,0.016277235,-0.073259205,0.08707979,0.0050680856,-0.1018704,-0.01201603,0.053760912,0.027226577,0.002628989,0.027944,0.011425275,0.08518659,0.041295577,0.03244665,-0.058223948,-0.0013288516,0.10904876,-0.0010754823,-0.066923544,0.022861065,-0.0531907,-0.020032056,-0.055884708,0.084433265,-0.04623147,0.008529009,0.028321845,0.032705568,-0.058987264,0.03655342,0.033854757,-0.016377814,0.026976977,0.0894278,-0.07254574,-0.02214563,0.054765414,-0.049110685,0.012212017,0.05605626,-0.010637894,0.030698508,-0.04030374,-0.0003774504,-0.048707463,0.040065713,0.035856754,-0.089715034,-0.060670674,-0.061438095,0.0008690338,0.06729725,-0.0047928067,0.055334993,-0.022861658,0.010004685,0.0025991045,0.018886285,0.031237949,-0.006879121,0.048390854,0.05861349,0.02079944,-0.055095922,-3.1679952e-05,0.03083002,-0.007817173,0.015139214,-0.0101506105,0.005496247,-0.04539964,-0.08205291,0.0034298734,-0.063405104,-0.03021454,0.06813735,0.03267487,0.019796526,-0.03263611,0.068095036,-0.06355587,0.032752562,0.06746837,-4.5703878e-08,-0.009168715,-0.085828654,0.059125304,0.019487651,0.045959517,8.2686485e-05,0.05689391,-0.01314243,0.077836625,0.0009911266,0.03538892,0.092521384,0.02989269,0.016074365,0.013642231,-0.01068351,-0.013725249,0.029231863,0.041448727,0.009287574,-0.013343907,-0.005979114,-0.046776813,0.0041153487,0.026892176,-0.027195219,-0.017419634,-0.05010194,0.03914135,-0.029685315,-0.017730562,0.031649973,-0.0037304035,-0.0054475996,0.0038218983,0.0598834,-0.0677578,0.0334762,-0.062765986,0.051063016,-0.024357004,-0.091079645,-0.054172914,0.008500511,0.04257747,-0.005985794,6.304223e-05,0.028489493,-0.01636978,-0.038642682,-0.012639347,0.005488216,0.014645215,-0.10445338,-0.10611516,0.06668788,0.0073057367,-0.061593127,-0.014362923,-0.07392907,0.07224573,0.021320246,0.22755264,0.029507924 +1.14.15.18,A P-450 (heme-thiolate) enzyme found in mammals.,384,1.0,-0.056849927,0.016095622,-0.0296265,0.011977288,0.048486307,0.04060103,-0.017995022,0.09103493,-0.02182041,0.049431246,-0.018459234,-0.014410036,-0.11384442,0.076443754,-0.016843557,-0.01235812,-0.045149095,-0.042528044,0.051884364,-0.096713305,-0.015153524,0.098657876,0.030138178,0.024829317,-0.030387567,-0.0070378548,0.08223052,0.046041165,-0.04825654,-0.04395978,-0.08602297,-0.07611357,0.052763343,-0.012134625,0.007285637,0.082875356,-0.1103409,-0.028675152,0.020563222,-0.04678583,0.12414137,-0.089483134,-0.06850199,0.009037244,-0.047035508,-0.023005638,-0.031625953,0.01668967,0.020931715,0.05305024,-0.021585729,-0.04399234,-0.044023022,0.032472633,-0.06038967,-0.054835018,0.06137266,-0.0056921947,-0.005812204,-0.03593601,-0.013911771,0.040103998,-0.017258931,0.010046945,0.016148904,-0.02561261,0.034302797,-0.045613434,-0.051601235,-0.0710393,-0.0040740613,-0.044576004,-0.02460663,0.06596275,-0.066657074,0.027180348,-0.012090314,-0.006839251,0.023540512,0.027284442,0.056099474,0.042755507,-0.009379062,0.06575858,0.04892384,0.03616461,-0.034983292,0.07438715,-0.06518254,-0.094524585,-0.0057327896,0.01720928,-0.08638893,-0.044347215,-0.085944615,0.053654827,-0.043648906,0.03192114,0.029385043,-0.032734394,0.016858881,0.01622389,-0.018403092,-0.08205533,-0.05147985,0.04889414,-0.035317153,0.036742736,0.1292193,-0.04749528,-0.048054215,0.007885311,0.027020926,0.019357769,0.04695357,0.08060271,-0.062813,-0.010942524,0.013129433,-0.023842689,-0.019412955,6.399561e-05,0.070219554,0.046876784,-0.031845186,-0.003492211,-0.06938777,-3.3040953e-33,0.09069787,-0.018919427,0.013540227,0.0035464119,0.0036782154,0.015789192,-0.042292688,0.056216832,-0.07204037,-0.008279621,-0.057041053,-0.13756895,0.017122956,-0.029147174,-0.001873423,-0.05863907,-0.019569935,0.03595603,0.032156236,-0.022625351,-0.04847856,0.0064021703,0.001065519,0.06131007,0.018390484,0.07969375,-0.029587634,-0.0025172976,0.07176408,-0.016157815,-0.031856027,-0.05597522,0.0055172015,-0.062565945,-0.025358541,-0.006291578,-0.02412046,-0.009041717,-0.035721682,0.029503452,0.04496956,-0.03229943,0.06820469,-0.06588866,0.04452187,-0.049461987,-0.11099261,0.03406377,-0.0057529598,0.004805354,0.034709267,-0.061368547,0.11854033,0.048725743,-0.061719615,0.0050045224,0.018757967,0.04046096,0.029179266,0.04165453,0.15486845,0.06327357,-0.03472274,0.050163127,-8.5233856e-05,0.04630227,-0.056510814,-0.028484639,-0.0076637277,0.16055106,0.0012757019,0.0036421958,0.029526848,-0.07970621,0.028065294,-0.049107153,0.022544272,0.117238455,0.039736528,-0.021775292,0.017913422,-0.010594626,-0.01294374,0.053757578,-0.010772962,-0.02934894,0.045865327,0.011865318,0.023078196,0.0018297359,0.07370382,-0.078284785,-0.05603927,-0.017867075,0.004449153,2.5565509e-33,0.087761216,-0.05747483,0.06191156,-0.03761476,-0.06571048,0.08892904,0.034365963,-0.015101655,-0.06612328,-0.004663031,0.10903478,-0.0220736,0.015623788,-0.06719808,0.07896507,0.028366297,-0.023508813,-0.0044302675,0.019895075,-0.0020103347,-0.015563924,-0.0091176005,0.012166407,0.0027657573,0.06273969,0.0038310976,0.00025722556,0.008535794,0.052983053,-0.037792742,-0.08623197,0.060009826,-0.08200917,-0.05309245,-0.023791289,-0.0028632258,0.02871852,0.0017151312,-0.0065371823,0.023237502,-0.04698372,0.097826734,0.036790323,0.09037324,0.010759038,0.12456272,-0.025345344,-0.062352017,-0.045662615,-0.032289147,0.021292198,0.007508446,-0.048315912,-0.015377824,-0.02774435,-0.007959253,-0.017853595,-0.0010155445,-0.0052479776,-0.11685947,-0.037450876,0.0076697064,0.0021599059,0.060179625,-0.0027995326,0.05511774,-0.041914545,0.03786149,0.025275582,0.010138392,0.018184528,0.008608289,0.03211847,0.047451805,-0.0039807167,0.028881958,0.016004566,0.0011329401,0.093203016,0.017406693,-0.013327411,0.023443874,-0.085767135,-0.046650644,-0.015405309,-0.103592806,-0.038445443,0.14406832,0.07757672,0.03431904,-0.07401052,0.04603137,-0.049871624,0.0196896,0.06981227,-2.2446393e-08,-0.03483571,-0.074677594,-0.00833493,-0.017357077,0.039984085,0.033327356,0.055950727,0.014856876,0.04659798,-0.025355011,-0.026564358,-0.0055466,0.00908046,0.005519956,0.0141481785,0.007621825,0.016761463,0.03964816,0.03618698,0.03811978,-0.07395352,0.024599839,-0.038500533,0.0368953,0.02647199,-0.041268263,-0.050153643,-0.0015485294,0.0075793155,-0.016370332,-0.04089554,0.058822755,-0.012154526,-0.056012113,0.07595978,0.067573726,-0.032075517,0.012247891,-0.061245978,0.022674307,0.016677333,-0.064941786,-0.04437258,-0.042369705,0.00087742,-0.010203926,0.035522223,0.019629035,-0.022931373,-0.07342064,-0.039586693,0.041826434,-0.014789887,-0.06725165,-0.1229912,0.0016519434,0.06662234,-0.10516492,-0.053196996,-0.11352722,0.07063618,0.0137273185,0.20945925,0.0098115085 +1.14.15.19,"The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P-450, and uses ferredoxin as its electron donor [1]. It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione [2].",384,1.0,-0.06865832,0.024819203,-0.13634825,0.0028279687,0.03227332,0.08948145,-0.028750004,0.038842835,-0.047871843,-0.06669486,0.040582225,-0.01969235,-0.05855699,0.025214918,-0.026111966,-0.033604898,-0.011395366,-0.0037372098,0.06478069,0.03677105,0.014197315,0.012959831,0.026436815,-0.00836316,0.05415334,0.019387763,-0.014657906,0.034600183,-0.055149402,-0.059892606,0.015274735,0.058462877,0.07887879,0.008741129,-0.039299555,0.04678088,-0.0728739,-0.05111549,0.05452187,0.050203443,0.011168984,-0.05424537,0.005443108,-0.02248119,-0.046393886,-0.049364153,0.027876917,0.00015122542,0.02873846,0.0038308185,0.006716316,-0.07629543,0.03931753,0.04231131,0.019193536,-0.022353822,0.020284468,-0.03017029,0.0020371983,0.018409567,-0.007848332,0.0089764325,-0.014755975,0.05600561,0.001141395,-0.035864644,-0.013695214,-0.07663113,-0.0569526,-0.07484782,0.011820431,-0.04748818,-0.023905529,0.027270075,-0.05464555,0.102294356,-0.043916903,-0.057823326,0.058650196,-0.011010285,-0.0073422445,-0.03615415,-0.002831593,0.13584955,0.0041196663,0.0056591765,-0.0038803087,0.046743885,-0.039955184,0.09100566,0.006919932,0.052036762,-0.024290854,0.0026666687,-0.11410347,0.05331434,0.041529782,0.02880922,-0.00039704362,-0.027511919,0.031096028,0.07677347,0.0020862217,-0.08608929,-0.057511926,-0.003549719,-0.022340236,0.04869179,0.045348477,-0.03724092,-0.01892837,-0.044642754,-0.045893796,-0.048061706,0.0035198112,0.08480569,0.027963819,-0.01881186,-0.09208924,-0.031008992,0.01109604,-0.040661972,0.04414952,0.08729648,-0.015180531,0.013807578,-0.10965166,1.2399646e-33,0.07206466,0.0094496785,-0.036162276,0.037954643,-0.008288742,0.03538034,0.012412675,-0.004980974,-0.03701891,-0.09472295,-0.11178586,-0.008511032,0.048679743,-0.0057455357,0.0338878,0.009437846,-0.022258695,-0.032371845,0.08670023,-0.0029986997,0.06885695,0.029056704,-0.03029996,0.002977422,0.028999971,0.06319,-0.035021625,0.010368938,0.0161073,-0.011613811,0.07613428,-0.046142194,-0.08841787,-0.025545051,0.061007056,-0.008593229,-0.018628633,-0.0029136916,-0.074261695,0.073894724,0.0461297,-0.016211262,0.022562517,-0.0676663,0.089514896,-0.04537762,-0.0606638,0.12831797,0.06817471,0.10633948,0.03539783,0.009322383,0.042716354,-0.005134597,-0.08067441,0.11703339,-0.0055276514,0.065544605,0.0022112904,0.06798187,0.042327665,0.058333296,0.018662265,0.102373436,-0.046627853,0.010730851,-0.006816499,-0.04991551,-0.051381666,0.104380816,-0.035144616,-0.033907365,0.049979135,0.016464207,0.06127469,0.038310487,-0.07182194,-0.016723843,0.10899936,-0.07785092,0.027501538,0.014493169,-0.034751717,-0.07500857,-0.015799887,-0.005229838,-0.08806058,-0.0437831,0.005131215,0.11185777,0.085385464,-0.17510901,-0.06684704,-0.038156815,-0.040649008,-2.0500197e-33,0.060794055,-0.09511349,0.05087194,-0.10504232,-0.0049436945,0.079926424,0.0962995,-0.011783994,-0.010910595,0.06493054,0.11651967,-0.025946517,-0.0064015966,-0.028633429,0.028823119,0.0037776427,-0.06800502,0.02291526,-0.023676343,-0.016962918,-0.011734434,0.03127263,0.054794606,-0.007575636,-0.019656837,0.043522835,0.007831353,-0.0067882035,0.12894349,0.031632166,-0.06857747,0.0034497953,-0.045832805,-0.059030574,0.029107962,0.09315675,-0.026426993,0.0045175524,0.06738923,0.005779952,-0.07461441,0.021289043,-0.0017318021,0.080182746,0.0723257,0.0138964215,-0.097837366,0.010736188,0.03355716,0.033237163,-0.025752418,-0.019999307,0.0012421262,-0.02565648,-0.030648377,-0.014855909,0.016965488,-0.006450577,-0.06921079,-0.0411344,-0.0018660929,-0.038883984,-0.015106724,0.05615104,0.0006295451,0.04922837,-0.044789158,-0.007823352,-0.03134406,0.002491189,0.08042283,-0.078201056,0.040195633,0.038058285,-0.020692207,-0.04717783,0.052769024,0.074537694,0.021717576,-0.0033175298,0.00018365814,0.021824498,-0.02446957,-0.017063824,0.038243327,-0.06599474,-0.0038526661,0.07797454,0.008540217,0.008814204,-0.048568703,0.04378527,-0.034919,-0.026981376,0.07408627,-3.9249095e-08,-0.054715097,-0.040605403,0.09940182,-0.05207908,0.08884266,0.00059994095,0.028491972,-0.07277219,0.05507566,-0.07554706,-0.005747981,0.14576104,0.026883913,0.0050592516,0.046103153,-0.02431067,-0.049395196,-0.011928544,-0.018145207,-0.045323893,-0.031879727,-0.050958212,-0.08578962,0.045762632,-0.022703482,-0.037997954,-0.027720928,0.059062578,0.020182421,0.017855968,0.019840533,-0.004208523,-0.049483433,-0.05065629,-0.031354956,0.03261635,-0.0023263067,-0.058668766,-0.015252849,0.029753476,-0.034795165,-0.105664566,-0.03579202,0.022797976,0.053862464,0.014854469,-0.0383741,0.034416046,-0.0024919133,0.011036457,-0.04684132,-0.033349916,-0.040026367,-0.06986971,-0.0815893,0.047039203,0.026255598,-0.053225037,0.013179119,-0.03948752,0.0016803207,-0.033213235,0.1558683,0.0061410163 +1.14.15.20,"The enzyme, found in plants, algae, and cyanobacteria, participates in the biosynthesis of phytochromobilin and phytobilins. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. Unlike this enzyme, which uses ferredoxin as its electron donor, the electron source for the related mammalian enzyme (EC 1.14.14.18) is EC 1.6.2.4, NADPH---hemoprotein reductase.",384,1.0,-0.06975068,0.03413704,-0.16369839,0.01677351,0.0666818,0.067021154,-0.020657223,0.04850342,0.07033469,-0.024180574,0.0067051854,-0.033292107,-0.13127913,-0.028763296,-0.018854467,0.09285887,-0.11155598,0.039815545,-0.0056248354,-0.030700715,-0.015210816,0.009164516,0.021977488,-0.005205907,0.039934434,-0.011896376,0.03360676,0.0061045364,-0.0075495453,-0.024559336,-0.013954804,-0.054786224,0.054111913,-0.034690313,0.019025145,0.063878804,-0.04550665,-0.097548656,0.0051590707,0.035292745,0.059404977,0.032721877,-0.018428309,-0.011088114,-0.07965224,-0.016155114,0.028926136,0.03794511,0.018260624,0.026600465,-0.05084293,-0.024456486,-0.0747347,0.013923911,0.024519546,0.049015004,0.020341212,-0.024853159,0.055918477,-0.022050766,0.012206549,-0.019656396,-0.0009206567,0.02417276,-0.051261615,-0.079213016,0.007872722,-0.08856261,-0.019373141,-0.10124651,-0.049764212,-0.06415873,-0.021137763,-0.01716478,-0.057260856,0.0759216,0.029995669,-0.009327965,0.028947126,-0.010854903,0.04363963,-0.029528657,0.009802997,0.10923691,0.0551015,0.0178767,-0.053908814,0.014126043,-0.06578563,0.03003977,0.02431751,0.02711918,0.007828981,0.004616668,-0.07393279,0.073756166,0.119566254,0.02906556,0.010743759,-0.01689758,-0.0138686355,0.07433795,-0.0043796333,-0.108950526,-0.058561575,0.028582642,0.023314858,0.09313369,0.076428555,0.01648483,-0.017536173,-0.023930635,0.023095606,-0.023875892,0.011531099,0.12854311,-0.0014687049,-0.004182774,-0.056054603,0.08871796,0.013042104,0.014827987,0.07694346,0.05432834,-0.016537948,-0.03297637,-0.11744766,1.8111668e-33,0.13328004,0.029241478,-0.013884502,0.012548405,0.005854202,-0.0012579425,-0.0823767,-0.051865723,-0.032850184,-0.10194659,-0.07863031,-0.07360387,0.076635145,-0.051868316,-0.041235395,-0.04572093,-0.049390513,-0.04261109,0.055717595,0.030352952,0.08364339,0.0051769535,-0.055481244,0.08668054,0.04462506,0.0073369816,-0.029081747,0.0720202,-0.002078688,-0.010480726,0.045374505,-0.058760874,-0.1196326,-0.017407238,0.04626095,-0.07100843,-0.03563558,-0.051310897,-0.064893484,0.05122452,-0.037437826,-0.009058507,-0.010800018,-0.05723744,0.14524388,-0.06377372,-0.075272314,0.07218363,0.075793274,0.120313875,-0.019610139,-0.038430948,0.1263616,0.05081926,-0.08585041,0.0048898305,-0.008680794,-0.010901413,0.034298263,0.045438074,0.04845525,0.08574149,0.03195403,0.016139982,0.035188146,0.067452945,-0.00275157,-0.07251584,0.00092870794,0.0264893,-0.0059667598,-0.0003693836,0.024041038,0.005126641,0.0348237,-0.016447702,-0.109253936,0.008783203,0.0027806766,-0.026423812,0.0380453,0.009580323,0.031580456,-0.04977268,-0.03634042,-0.0134899225,-0.04839079,-0.057845574,-0.011512977,-0.0059320005,0.08440647,-0.08241009,-0.0984584,-0.074762926,0.011910918,-1.4376233e-33,0.069386415,-0.04193085,0.028697364,-0.061083145,-0.018450504,0.035469428,0.010067226,-0.07832505,-0.0067500905,-0.0029665467,0.036575906,0.014014653,0.02122613,-0.0383152,0.062422194,0.008990726,-0.01590527,0.061518494,0.04470271,-0.020019146,0.0010314446,0.01419528,0.007897767,0.024570491,0.061169323,-0.024652839,-0.060293872,-0.023807589,0.10143365,-0.023586944,-0.04748603,0.044374347,-0.07683957,-0.028221674,-0.0023173424,0.044300642,-0.084157094,0.029246664,0.054141764,0.016732158,0.022480574,-0.025110096,-0.0025200925,0.011172306,0.042601112,0.057586975,-0.049130607,0.031530153,-0.022516878,0.000798907,0.010100804,0.05644995,-0.012680731,0.006021623,0.059225764,0.030958917,0.0937083,0.06593477,0.035962034,-8.1674334e-05,-0.0051570954,-0.06576412,0.056610476,0.07670959,-0.0073682843,0.087078035,-0.00042472483,0.10199076,0.058489613,-0.01962012,0.08502935,0.02679663,0.047716837,0.07543213,-0.066430636,0.006724123,0.061685104,-0.0026598345,-0.03564034,-0.009358489,-0.0060521318,-0.0081759775,0.041582134,-0.042838793,-0.027355967,-0.09231277,0.034391373,0.030391423,-0.013699086,-0.0005870503,-0.041653644,-0.013687007,-0.037914272,0.03220848,0.061194524,-4.1942116e-08,-0.03699141,-0.012760116,0.021547493,-0.008186282,0.06841067,0.027843757,0.040728524,-0.02725804,-0.0038155785,0.02373954,-0.009183666,0.070906736,0.03529462,-0.023986615,0.059779283,0.057949703,-0.0056432853,-0.016774027,0.018296933,0.013648394,-0.023160653,-0.026718056,-0.14662595,0.072423786,0.00071627833,-0.07829029,-0.05691774,0.032694496,0.0217523,-0.010140999,0.0149382055,0.027235823,0.051827826,-0.041728187,-0.07402624,-0.0064802165,-0.06510792,-0.044784665,-0.04589599,0.009836701,-0.044667345,-0.058699794,0.0065397806,-0.028592534,-0.0178939,0.04251745,0.01967724,0.020144207,0.006208997,-0.016329356,0.0283937,-0.038974177,0.0069150804,-0.08659894,-0.1033813,0.07422345,0.016320426,-0.037332524,0.017117137,-0.055049423,-0.056895453,0.04231376,0.14778028,-0.022829564 +2.1.1.325,"The enzyme, found in insects, is involved in the synthesis of juvenile hormone III, a sesquiterpenoid that regulates several processes including embryonic development, metamorphosis, and reproduction, in many insect species.",384,1.0,-0.02554453,-0.044778705,-0.08334829,0.0024603845,0.017186554,0.07773493,-0.04370161,-0.0072565367,0.009187974,0.061588496,0.08853825,-0.043993726,-0.06649902,-0.028005267,-0.0054179854,0.110367954,-0.02160111,0.034384023,0.023881102,-0.11899433,0.033908635,0.030483743,0.034391772,-0.0021840131,0.035033938,0.0011329674,-0.02169284,-0.013982486,0.008020265,-0.0827507,-0.02495203,0.019764125,0.062103104,-0.06722383,0.019919079,0.024253035,-0.06427248,-0.08465083,0.069990315,0.054670375,0.07195678,0.016802086,-0.107135326,-0.09110154,-0.08388466,-0.039983142,-3.29728e-05,0.049286827,0.041487515,0.0008935152,-0.0065175053,-0.122913584,-0.01277468,0.094968416,-0.0006213149,0.0075053275,0.028455226,-0.03056245,-0.029225871,-0.0013606303,0.007079629,0.06296706,0.037581205,-0.022565674,0.034692924,-0.03756427,-0.015860751,-0.04084978,0.014865387,-0.07078205,-0.053653415,-0.07320271,-0.005183394,0.05829812,-0.027548878,0.016056614,0.0012447111,-0.012158889,0.059744406,-0.040002815,-0.020418668,-0.026596854,0.06270626,0.0997335,0.00933402,0.009683977,0.0013722975,-0.007418356,-0.057710458,0.077279225,-0.002474982,-0.07376412,-0.021240132,-0.01733809,-0.018576808,0.045139726,-0.023585314,-0.06358577,0.013467818,-0.0073287617,-0.001586121,0.03954053,-0.023186103,-0.020504972,-0.09417978,0.017314244,-0.017022042,-0.012117287,-0.0014973863,-0.0009811858,0.00167783,-0.016521432,0.08046675,0.07272126,-0.02129496,0.05466407,-0.018058423,-0.0052262456,0.05804257,0.052429914,0.082165115,0.0153314145,-0.024698626,0.04018614,0.024685077,-0.008946718,-0.10960022,-1.2246181e-33,0.08758537,0.059899673,-0.025118677,0.04009964,-0.070526436,0.021537041,0.0064414297,0.088575,-0.06643928,-0.07724735,-0.10512666,-0.11771161,0.039037872,0.026189543,0.04898829,0.021951146,0.016506296,0.00037439304,0.15549713,0.012151264,0.024407957,-0.020292126,-0.046524987,-0.09104601,0.08500953,0.098792665,-0.028980438,0.039027706,0.0075146076,-0.0069831545,0.12142201,-0.058120236,-0.041450374,0.09038186,0.080583595,-0.050014306,0.039044157,-0.05787092,-0.11864817,0.05866411,0.024296762,-0.020876916,-0.014913705,-0.018172374,0.054819956,-0.060386818,-0.1013706,0.031146688,0.14730869,0.043983106,0.026677595,0.04545844,0.1513718,-0.028313264,0.003040429,0.0640137,-0.07232647,-0.08365771,-0.085938886,-0.029436836,-0.029784169,-0.030983798,-0.05809651,-0.018852971,0.05626532,0.057881836,-0.050253216,-0.06232217,-0.028104743,0.0049222116,-0.046037458,-0.027275853,-0.02713935,-0.0338642,0.001286249,0.02305964,-0.06733146,0.035884473,-0.017480189,-0.03745465,0.021692077,-0.085053265,-0.017072663,-0.02363501,-0.03131311,-0.07319524,0.047027204,-0.010751145,0.08343243,0.022485103,0.032066315,-0.09209344,-0.06251267,0.062299248,0.013855531,-3.4232434e-34,0.008972693,-0.08308873,0.0094739655,-0.061316032,-0.04483621,0.07228997,-0.018289367,-0.009092207,-0.021157002,0.017614173,-0.013754794,0.06332514,0.029173588,-0.116174,0.037912887,-0.024823627,-0.008276336,0.024631403,0.06702324,-0.048687577,0.008417202,0.082841,0.02287165,0.014850268,0.030876344,-0.002326863,0.015810393,0.026201887,0.016879054,0.10277752,0.0060867188,-0.015275617,0.07510587,0.01674417,0.005655739,0.026791444,-0.060033966,-0.03720637,0.03297674,-0.001563175,-0.011401112,0.040578675,0.03522542,0.021507982,0.08537865,0.048508316,-0.06826255,0.08125787,0.041561224,0.0039724903,0.0109864725,-0.029416174,0.020499062,-0.028826587,0.0047355373,-0.0029887522,-0.02026453,-0.0542855,0.012420812,-0.04049595,-0.010649517,-0.050336238,0.009905009,0.029440098,-0.008781382,0.028187884,-0.052751545,0.024118973,0.042582434,0.023482634,0.040149916,0.013349864,0.041518554,0.008623661,-0.037294157,-0.0805204,-0.010310379,-0.0004983015,0.025823789,0.0041200207,-0.026777498,0.029710416,0.00537336,-0.07134633,-0.020203615,-0.06725215,-0.038059436,0.113629386,0.0035379212,-0.011057577,-0.06250198,0.015978727,-0.06803101,0.025593504,0.053692028,-3.0671007e-08,0.06106209,-0.0024924814,0.0031253402,-0.017610755,0.037711848,-0.025557306,0.029080668,-0.02110113,0.016546192,0.01942963,-0.052490253,0.069122955,0.12840258,-0.017738163,0.11831747,-0.03706488,0.0665062,0.027887188,-0.034919757,-0.07064292,0.011786228,0.038739286,-0.08065329,0.036876515,0.030895775,-0.103689365,-0.005637284,0.007331142,-0.012665049,0.07425621,0.025696399,0.03955074,0.09016676,-0.036808267,-0.076983504,0.01503486,-0.04156296,-0.04605567,0.06045921,-0.06630152,0.01701504,-0.0009739045,-0.006327722,-0.055175953,0.0019894447,-0.012228864,0.06451782,-0.009374711,-0.027080836,0.010412933,-0.034555193,-0.025551392,-0.039096646,-0.0153221125,-0.056957364,-0.04024079,-0.010399595,-0.07491682,0.010380714,-0.032717694,0.012044516,0.033562068,0.17842767,-0.037287958 +2.1.1.326,"The enzyme was originally characterized from bacteria that produce the tripeptides bialaphos and phosalacine, which inhibit plant and bacterial glutamine synthetases. It is a radical S-adenosyl-L-methionine (SAM) enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. According to the proposed mechanism, the reduced iron-sulfur center donates an electron to SAM, resulting in homolytic cleavage of the carbon-sulfur bond to form a 5'-deoxyadenosyl radical that abstracts the hydrogen atom from the P-H bond of the substrate, forming a phosphinate-centered radical. This radical reacts with methylcob(III)alamin to produce the methylated product and cob(II)alamin, which is reduced by an unknown donor to cob(I)alamin. A potential route for restoring the latter back to methylcob(III)alamin is a nucleophilic attack on a second SAM molecule. The enzyme acts in vivo on N-acetyldemethylphosphinothricin-L-alanyl-L-alanine or N-acetyl-demethylphosphinothricin-L-alanyl-L-leucine, the intermediates in the biosynthesis of bialaphos and phosalacine, respectively. This transformation produces the only example of a carbon-phosphorus-carbon linkage known to occur in nature.",384,1.0,-0.045676727,-0.06717511,-0.11140293,0.048076674,0.022591408,0.077211484,-0.06044373,-0.020047048,0.047851216,0.030620262,0.03910335,0.021167684,-0.021970576,0.05145084,0.0018803348,0.08263208,-0.061956327,0.023519348,-0.0026640212,-0.0028251403,0.03293005,0.022476338,-0.069365874,-0.00799901,-0.0061044088,0.055049177,0.08228386,0.0066397698,-0.06748106,-0.05406099,0.027313516,-0.042879604,0.06292493,-0.020760443,-0.0026824686,0.07076758,-0.02153391,-0.05117688,0.10164773,-0.003473169,-0.035753142,0.069556005,-0.0077243852,-0.04051409,-0.03340262,-0.049820095,-0.0041290196,-0.008424902,0.07528231,-0.052779626,-0.013858983,-0.05205808,-0.04266916,0.07965394,0.081815206,-0.02099391,-0.12474177,-0.036316585,0.014238397,-0.016400907,0.0043145358,-0.047855295,0.040390458,-0.039827548,0.018104866,-0.004105518,0.011726448,-0.09181487,0.0557625,-0.034202084,-0.04943075,-0.034658022,-0.009616332,-0.00040386224,-0.010840694,0.0063426015,0.009535924,-0.024561837,0.047728017,-0.04567006,0.025984416,0.0062884707,0.029806951,0.05423757,0.025993329,0.048232157,-0.037548345,-0.016261198,0.05176363,0.035490386,0.031342752,-0.03650702,-0.014223709,-0.10979363,0.04034241,-0.0074260295,-0.036638897,0.028778773,-0.039011266,0.017189804,0.027178181,0.09773965,-0.095769994,-0.122724324,0.02762503,0.029070565,-0.0059851906,0.0519948,0.018250184,0.058484416,0.042492718,0.049367666,0.0071453233,-0.000946604,-0.051372904,0.10716163,0.10159495,-0.038056027,-0.04551696,-0.030569585,0.054382652,0.024142362,0.044283107,0.04071046,-0.03498681,0.05028632,-0.14759016,1.5027098e-33,0.07735758,0.08855668,0.014494037,-0.027214842,0.0054184566,-0.11048411,-0.09854398,0.02441711,0.0072743883,-0.036834903,-0.08814405,-0.044425417,0.101025544,-0.073305026,-0.049184516,-0.0162237,-0.07148073,-0.0020207183,0.02272453,-0.0038401769,-0.045237903,0.008244678,-0.012815206,0.029241947,-0.041494727,0.06372096,0.016866658,-0.0051427577,0.01533092,0.0144922845,-0.028993934,-0.010965862,-0.08305782,0.036763113,0.020709964,-0.0069377483,-0.07189528,-0.049919344,0.006777375,0.030339919,-0.01870788,0.0022827482,-0.03923001,0.04026569,0.096739195,-0.08164651,-0.043926496,0.08932539,0.045047678,0.091675736,-0.015449531,-0.029088886,0.12970887,0.023545722,-0.12853847,-0.019194592,0.040736716,-0.0813132,0.035012115,0.11834535,-0.005537669,-0.0062549226,-0.067683086,0.03773141,-0.01927009,0.0065540127,-0.0770053,-0.042148825,-0.036538072,0.088241935,0.015174181,-0.0035066921,0.049345423,0.07065501,-0.029935751,-0.029557476,0.05551359,0.07390473,0.03721634,0.019911604,0.00865325,-0.011928165,0.024257813,-0.0036832364,-0.070244,-0.0300296,-0.007346294,-0.082681686,-0.039611585,-0.0040319124,0.042783372,-0.029187836,-0.050325975,0.027262617,-0.02810789,-2.6730475e-33,0.0708712,-0.06964327,-0.02465344,-0.07718224,-0.08054774,0.021299874,0.02293468,-0.039889436,-0.023247598,-0.07448464,0.070017666,0.00030293124,0.04263012,-0.04557211,0.06912202,0.019714583,0.026364308,0.023573173,-0.028454816,0.0015074426,0.04565656,0.091667436,0.009462329,-0.022125399,0.07982343,-0.03646794,0.034279194,0.06478012,0.091182604,0.08680536,0.020957395,-0.031224012,-0.05978332,-0.06830296,-0.0065583475,0.06890402,-0.028006405,0.030332414,-0.007572107,-0.004744326,0.027719392,0.026030885,-0.008459313,0.11107679,0.052658617,0.09489768,-0.07659348,0.050215386,-0.044364836,-0.05483969,0.024330543,-0.0054505323,0.0077707516,0.012978672,-0.023982761,0.08072761,0.0291453,-0.011039085,-0.04275842,0.01857885,-0.05892605,-0.05860965,0.07009554,-0.023806425,0.0041350853,0.009753786,0.023537995,0.051717635,0.024529222,-0.001584036,-0.046775766,0.021647763,0.03842068,0.023116827,-0.040640485,-0.012836792,-0.069412954,-0.00024173311,-0.021804228,-0.0003229103,-0.02096591,0.018276846,-0.010190662,-0.028305998,0.040032454,-0.032472063,0.037020817,0.16410856,0.0087725585,0.0025495517,-0.070175126,-0.026914591,-0.051056482,0.06598532,-0.027617136,-5.2648485e-08,-0.029867781,-0.07144183,0.017475015,-0.031531844,0.03671144,0.10968737,-0.02215754,-0.045381334,-0.0053690537,-0.06708436,-0.02002772,0.13847812,-0.04028414,0.016083527,-0.06550637,0.013265862,-0.07894428,0.05460871,-0.001475438,-0.031331144,-0.085212596,-0.019523768,-0.0834653,0.021972591,0.025530793,-0.025326695,0.045335345,0.061637297,-0.047265254,-0.03041901,0.014310067,0.018027462,-0.057614733,-0.033994403,-0.13922592,-0.021862615,-0.03832598,0.021841256,0.023182832,0.047650706,-0.014383187,0.025451716,-0.096303724,0.06049958,0.02141256,0.01814012,-0.009937742,0.04909952,-0.018763913,0.013880499,0.07239693,-0.023451226,0.012681614,-0.023750694,-0.10282013,0.01175565,0.0072423727,-0.11605078,0.05486777,-0.02292021,0.03488525,-0.012228369,0.09061573,0.04083087 +2.3.1.252,"This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyltetracosanoate (C27-mycolipanoate). Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal.",384,0.99999994,-0.04849427,-0.023333203,-0.06665405,0.018185198,-0.010140813,-0.030662103,-0.052796613,0.088143155,-0.035184637,-0.0152070355,0.013532921,-0.114193946,-0.023727914,0.0112218205,-0.0367773,0.037011366,0.017289363,-0.013885122,0.039863735,-0.014919258,0.04986778,0.06948879,-0.026028536,-0.042334657,0.04069282,0.0029203878,0.06868301,0.017329562,-0.003102253,-0.10402196,0.008892124,-0.07993555,0.112657025,-0.0405951,0.10814075,0.04163124,-0.011542606,-0.084025234,0.07700035,0.027784472,0.083273456,-0.048171937,0.010321119,-0.008353359,-0.011469229,-0.026708044,-0.05378738,0.042715453,0.034448054,0.007790352,-0.09316954,-0.04400853,-0.08064889,0.094385296,-0.017485177,-0.037608836,-0.028114745,-0.014837168,-0.04188853,0.049736615,0.108086586,-0.0112908585,-0.024179934,0.060487997,-0.010509649,-0.08374376,-0.0134531995,-0.0019985498,0.036460135,-0.015792953,-0.0395102,-0.032077696,-0.040211357,0.09070785,0.011369383,-0.01331006,0.03635553,-0.064869225,0.04062893,-0.0082129985,-0.061418157,-0.04871758,-0.0019485899,0.019165594,0.0112999445,-0.036119148,0.089916304,0.012546825,0.019321041,0.09805821,0.07970679,-0.037128355,-0.018647788,-0.088372715,-0.07328141,-0.01879785,0.068848275,-0.01064482,0.010409343,-0.004375316,0.013889414,-0.05382474,-0.018218538,-0.079388335,-0.09171089,0.060421012,-0.06749599,0.01539808,0.05573636,0.049094543,-0.080903254,0.024560306,-0.010523317,-0.010265102,0.0031180745,0.07555148,0.054759957,-0.07916544,-0.03810081,0.0393194,-0.022446452,-0.078428425,0.05730329,0.007419096,-0.077789426,0.049470846,-0.0476779,1.6371644e-33,-0.009565289,-0.0026370452,-0.03245709,-0.048604693,0.04525126,-0.047931578,-0.089342296,0.0028743462,-0.10974317,-0.023814637,-0.012590081,-0.090681456,0.04192302,0.08293264,-0.08646452,-0.0020258154,0.035766087,0.049347017,0.08513306,0.018369727,-0.0028475765,0.09760429,-0.0015072915,0.01773808,0.007883669,0.05581072,-0.013370895,0.05117283,0.057498522,0.0356183,-0.01189114,-0.054827392,-0.057427462,-0.036992952,0.0504866,0.004634084,-0.01828859,-0.09141403,0.015268269,0.042329405,0.06928291,-0.0352497,0.01197778,-0.007462198,0.031427067,-0.049768526,-0.03311209,0.04944191,0.027281212,0.035124637,0.03968273,-0.06135375,0.062204096,-0.027199753,-0.03827483,0.0011162166,-0.07322485,0.00666439,0.046148576,-0.0602869,0.049342457,0.06927984,-0.10175554,0.0646579,-0.033493552,-0.043557975,-0.05688258,0.02084672,0.014770165,0.010099034,-0.007039107,-0.030664327,0.03579724,0.0061204834,0.08937839,-0.06354797,-0.04839956,-0.014270318,0.025291944,-0.06279189,0.052188847,0.017232178,0.02644804,-0.04555335,-0.0030346229,-0.004865707,-0.102187306,-0.015797334,-0.0037554298,-0.025340913,-0.017303396,-0.07135255,-0.039590098,0.08613904,-0.018869411,-4.875302e-33,0.11123557,-0.12022682,0.1091257,-0.080225386,-0.018117774,-0.022849414,0.045499604,0.07140587,0.013098226,-0.019022007,0.106447816,-0.04940064,0.03411883,-0.029935678,0.0076908316,0.06342547,0.012338631,-0.0021060035,-0.04638799,-0.07124877,0.02502045,-0.019717636,-0.0032156848,0.068055235,-0.052759502,0.01884795,-0.0689994,0.02424313,0.031675145,0.09631003,-0.02679805,-0.0945488,-0.0007307549,-0.10886954,-0.049779553,0.017318165,-0.076620184,0.007695672,0.0106848385,0.024231926,0.018020747,0.025400566,0.0072463495,-0.0113306865,0.007228026,-0.042962387,-0.07621843,-0.016831513,0.000112045556,-0.08987908,-0.017888801,0.0034305865,0.0068399655,0.04698234,0.011277933,0.06050387,0.043565974,-0.009753028,0.01453463,-0.0662069,-0.048199326,-0.074504435,0.014414942,-0.011652492,0.15227622,0.08015312,-0.019202681,0.022312697,0.009533075,-0.045484733,0.0275952,0.042960137,-0.05406504,-0.029862167,0.008021103,-0.029062573,-0.013358252,-0.005591217,-0.027395232,-0.02367644,0.023218535,-0.0673639,0.00739939,-0.13017796,-0.056781236,-0.06957451,0.03201351,0.06131362,-0.042073186,0.052355178,0.013872546,0.08424695,-0.010085713,0.04403113,0.061096482,-4.1750358e-08,0.027996944,-0.06470255,0.06533178,0.014964717,0.056069132,0.021737698,-0.06846439,-0.030987702,0.0903592,-0.010369245,-0.02763262,0.08164539,0.03297485,0.0099267075,0.0501673,-0.0065597836,-0.07281785,-0.0029966692,0.004657501,-0.04213636,-0.0956332,-0.017433304,0.004627525,-0.0039956276,0.049623188,-0.0059098313,-0.014752258,0.08035592,0.032291956,0.05353913,-0.023039898,0.08657926,-0.035018347,-0.019695507,-0.053106092,0.0030812882,-0.037241876,-0.07719478,-0.065283775,0.07674664,0.120233975,0.05775843,-0.05023835,0.031279124,0.021653222,-0.0012293424,0.0060195946,0.02298334,-0.027677326,0.044296205,0.0055190423,0.019793943,-0.08057635,0.024777588,0.014289686,0.017638853,-0.0128738545,0.027659867,-0.052159708,-0.014177268,0.08283504,-0.008578885,0.15342744,0.005173597 +2.4.1.338,"The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A.",384,0.99999994,-0.033429634,0.044675607,-0.16294442,-0.013998492,0.015212225,0.06817694,-0.09433749,0.06807935,0.08998419,-0.03584691,0.010245691,-0.013308682,0.015462879,-0.010281165,-0.086871654,-0.020927265,-0.04500293,0.013392312,-0.010343315,-0.057497893,0.11336006,0.040805917,-0.000111490044,0.0069403923,0.017799458,-0.032851968,0.008241165,0.022014948,-0.043507557,-0.08800729,0.051157773,0.002885646,0.05412453,-0.05087386,0.08622485,0.08485514,-0.011399217,-0.06880638,0.15532494,0.023701044,-0.009058274,-0.066646874,-0.036029577,-0.025314461,-0.0652129,0.010034073,0.026432045,0.047295548,0.029022772,-0.018131955,-0.069539614,-0.03954046,-0.074168436,0.03428341,0.033658043,0.026184672,-0.013915522,-0.02067111,0.012356859,-0.09338672,0.067074254,-0.019544547,0.009917063,0.062182624,-0.13653412,-0.037376635,-0.009804821,-0.07739612,0.038471397,0.0017402892,-0.063944764,-0.006192618,-0.070526175,0.071994714,0.028215015,0.043802034,0.009141153,-0.07517393,-2.666502e-05,-0.04482206,0.06543105,0.017062549,0.014631969,0.079743534,0.02056056,0.025409076,0.005545636,-0.0060562785,0.08926971,0.004751102,0.056976534,-0.038638264,-0.00472243,-0.048407055,0.0053842342,0.010747773,-0.024336856,-0.015958074,0.045953035,-0.003955362,-0.04561394,-0.019412732,-0.023110105,-0.05697693,-0.02539457,0.031143574,-0.0030450216,0.051552612,0.07399332,-0.047471344,-0.006800143,-0.0330369,0.04184042,-0.024798846,-0.03007205,0.058277607,0.1388907,-0.0073805563,-0.09484181,-0.05946959,0.03285972,0.004121595,0.06008576,-0.021622688,-0.025708416,-0.028258806,-0.082787454,1.8781094e-33,-0.03940258,0.044744775,0.0013728398,-0.05584081,0.062077485,-0.01256707,-0.043453075,-0.006910194,-0.0067113293,-0.041206393,-0.09034251,-0.059321947,-0.060430095,0.04501182,-0.0023166742,-0.0032709928,0.016866729,0.06095581,-0.05879494,-0.00028778106,0.008435821,0.017976094,-0.0078184465,0.0054784464,0.007273362,0.044510607,0.033780843,0.02706973,0.0955785,-0.030961107,-0.021155022,-0.072652616,-0.014705755,0.009687599,0.036064092,0.0061582588,-0.08299909,-0.048008215,0.048347287,0.0042821676,-0.026682254,0.018064292,-0.003929507,-0.02239151,0.004826182,-0.007075182,-0.06619487,0.066718146,0.084629096,0.055856474,0.0584106,-0.009217826,0.10685178,0.005510103,-0.06997277,0.012452338,-0.05263939,0.059585888,0.036425393,0.05150046,0.0019470847,0.039985385,0.020448761,0.056528196,0.016020993,-0.033897262,-0.06882323,-0.0051447754,0.007992325,0.05615861,-0.043265577,-0.013231986,-3.1282565e-05,0.04251252,0.032795697,-0.04640348,-0.04427125,-0.034223095,0.03220006,0.013434905,-0.060313504,0.008530441,0.004899995,-0.032557223,-0.046101138,-0.0033221438,-0.0646212,-0.03474077,-0.00050298654,0.08271258,-0.07871106,-0.04672645,-0.07964924,0.07332683,0.039711185,-4.118576e-33,0.1025384,-0.08444696,0.06826568,0.0040738783,-0.023679439,0.11729601,-0.027385501,-0.042504024,-0.020318814,-0.029328376,0.06493006,-0.042281024,0.008714234,-0.05556966,0.043670144,-0.023042077,0.02649761,0.038881123,-0.05854305,0.06365687,-0.015670996,0.08596998,-0.07934181,0.0053662085,0.040119827,0.0059989276,-0.010517312,0.10256248,-0.026377771,0.09882318,0.08197345,-0.031353574,-0.054968596,-0.010662837,-0.006498779,0.10777903,0.011561345,-0.015194521,0.100955606,0.013551837,0.08698982,-0.028041156,-0.010198908,0.02830997,0.028180407,0.055233885,-0.07153293,0.05061281,0.011367242,-0.05756578,-0.010560929,0.06474035,-0.014849856,0.041692007,0.042791497,0.025837466,-0.029093502,0.010469876,-0.00947036,-0.04008853,-0.08616645,-0.045566145,0.024229521,0.052324858,0.048644196,0.038767304,0.0053902767,0.0060076094,0.10334336,-0.06881765,0.11218625,0.03678899,-0.05370479,0.07158485,0.0026896358,-0.00820197,-0.054344777,-0.07724274,0.017615857,0.0011803133,-0.034971777,-0.051228702,0.040468212,-0.0470989,-0.027580962,-0.06943167,0.059890915,0.010164,-0.045827307,0.046893705,0.047094803,-0.021775687,-0.013101533,-1.4244921e-06,0.06313539,-3.201043e-08,0.025036791,-0.049688555,0.09188393,-0.044365145,-0.019166972,-0.051820915,-0.0003039534,-0.026540915,0.00971181,-0.02468675,-0.012353291,-0.017414354,0.0102623515,-0.033318006,0.009420781,-0.030221328,-0.06694116,0.061172657,-0.006472798,-0.001361049,-0.05707055,-0.02375395,-0.13920592,0.0044269515,0.0538603,-0.07394258,0.028182874,-0.022504797,-0.018075135,-0.00088750065,0.07055996,0.0046036313,-0.031090438,-0.0066098785,-0.057593983,0.015541837,-0.06684394,-0.026086407,0.067109585,0.007742697,0.03293423,0.0078028417,-0.08612592,-0.047679834,-0.106834754,0.024334999,-0.0151845785,-0.018343994,-0.10767484,0.019175798,0.06358125,0.03728032,0.032877836,-0.0030956126,-0.079214334,-0.010367135,0.024434993,0.0034794891,-0.056491762,-0.045052353,-0.002756736,0.0067109787,0.24143316,-0.062829725 +2.4.1.339,"The enzyme, originally characterized from the thermophilic anaerobic bacterium Thermoanaerobacter sp. X514, catalyses a reversible reaction. cf. EC 2.4.1.340, 1,2-beta-oligomannan phosphorylase.",384,0.99999994,-0.03923162,0.013960415,-0.099173605,0.026627945,0.026865695,0.010762774,-0.033711143,-0.014219834,0.024432043,0.05153303,-0.038584046,-0.06641743,-0.037676193,0.059138395,-0.059527885,0.042677965,-0.07981118,-0.04096381,0.058308095,-0.022159744,0.08294184,0.04412573,-0.01256279,0.027435977,0.07694792,0.021883884,0.038990505,-0.018083664,-0.092203334,0.012761942,-0.0038363475,-0.04744011,0.11649328,-0.023608819,0.06643643,0.09689433,-0.053007804,-0.07127969,0.056243483,0.057015013,0.027890002,0.027896464,0.025430594,-0.017622365,-0.06442084,0.03530588,0.0074991873,-0.016645458,0.026701093,0.002801408,-0.02959243,-0.025094146,-0.066437356,-0.0021253086,0.05383756,0.013038206,-0.04327829,-0.049993772,-0.049822778,0.008674048,0.06317858,-0.0013536409,-0.006499077,0.057674047,0.015681082,-0.0605292,0.048555553,-0.111552455,0.036081117,-0.012919482,-0.07489678,-0.036641467,-0.021620965,-0.023613762,0.045550663,-0.059377287,0.032520395,-0.018746983,0.035629474,-0.013618323,0.0068180696,-0.041801825,0.011577792,0.017895894,-0.022784714,0.017025605,0.032199033,-0.013611789,0.16077359,0.024062056,-0.038427446,-0.011034944,0.036875393,-0.08017318,-0.025435248,-0.019368285,0.015640471,0.02376555,0.09462847,-0.037655767,-0.0031163516,0.056458425,-0.023336656,-0.08139752,-0.023063933,0.03204918,0.03920626,0.09397417,0.008846056,0.037793174,0.017862542,-0.029639835,0.12397374,-0.003719768,0.028962428,0.04173063,-0.03682254,-0.057640966,-0.07433973,-0.0061435327,0.011063764,-0.05258146,0.01060858,0.061248843,-0.109898165,0.08872678,-0.13443542,1.2016766e-33,0.053140644,0.06425513,0.009562344,-0.022882458,0.018613249,-0.007752492,-0.037426982,0.01112582,-0.037742883,-0.07260835,-0.0011391541,-0.02529993,0.038340084,0.040004,-0.009173574,-0.033141684,-0.017852068,0.06866382,0.041605316,0.058531485,-0.044386394,0.07085258,0.0061080554,0.0027545341,0.05080673,0.054019637,-0.019640246,-0.016497381,0.03471046,-0.005214634,0.055128586,-0.06733159,-0.14143553,-0.025925253,0.034066692,-0.046944678,-0.06329597,-0.0061156065,-0.0039406735,0.0047436855,-0.054764837,0.05022347,0.0054482636,-0.013215534,0.024894394,0.0035242878,-0.033368744,0.09774621,0.026461424,0.03581406,-0.024263456,0.011346812,0.10621096,-0.043961197,-0.052557293,0.04641418,0.011576159,0.023209823,0.010848537,0.022067081,-0.00015834703,0.10638542,-0.03483588,0.039577816,-0.02053091,0.0067613637,-0.0005701477,-0.07946399,0.022450777,0.10044229,-0.08184096,-0.001709967,0.013380403,-0.015326195,0.025489515,-0.07714957,-0.027852803,-0.10451959,-0.041379903,0.0100162905,-0.047427837,-0.021944573,0.03140991,-0.058582712,-0.028673336,-0.036606397,-0.0032564544,-0.01944197,-0.031037439,0.08669829,0.008637908,-0.0797907,-0.038312096,0.06724465,0.0018089719,-2.1915184e-33,0.10996548,-0.11711836,-0.040696763,-0.0627593,-0.10037019,0.057912845,0.019253947,-0.0051643793,-0.035612166,-0.017669449,0.08004137,0.00090023305,0.049982246,-0.024824966,0.06345798,-0.024543377,0.01977203,0.07239577,-0.011613377,-0.0006582912,0.029205088,0.101071425,-0.03892391,-0.056293834,0.039909635,0.024099795,-0.027888745,0.121583596,0.044423487,-0.016906487,-0.04522873,-0.02950761,-0.009056838,-0.06726023,-0.04436874,0.06459742,-0.027278557,-0.0305465,0.07018448,0.041224256,0.051887434,0.035172127,-0.0069242395,0.07250505,0.026882926,0.038772453,-0.08442308,0.057779312,-0.0026554717,-0.044878975,-0.016659908,0.0036468096,-0.027372224,-0.005889293,0.022314243,0.048318114,-0.04930966,0.047876302,-0.007597458,-0.049707692,-0.06041451,-0.068647265,0.13700469,0.07764913,0.022515325,0.07917378,-0.039237097,0.014424564,0.019825274,-0.001440339,0.044249363,0.016354008,-0.039854363,0.058228992,0.021428978,-0.01911982,-0.10425784,-0.010489927,0.013409777,0.011338252,0.009406276,0.025586175,0.07382942,-0.0053195707,0.020800924,-0.11317891,0.06743557,0.06647811,-0.052802317,0.054243576,0.048879962,-0.0747216,-0.01981523,0.07260068,0.06370424,-3.407391e-08,0.0045852056,-0.036572322,0.09881154,-0.043113705,0.025453182,0.03764943,-0.001528353,-0.04853662,0.051044248,-0.06887236,0.018260192,0.05717523,0.036433253,0.03918913,0.029392198,0.01092367,-0.106765546,-0.03164622,-0.049418256,-0.0035144049,-0.04566134,-0.042321887,-0.14656979,0.048815083,-0.017190875,-0.023123642,-0.0055838358,-0.0022480912,-0.07416143,-0.033234973,-0.06385486,0.0017240527,-0.017342264,-0.03606152,-0.06322034,0.014900298,-0.01950642,-0.055455506,-0.015237319,-0.002461837,0.036781017,-0.009457496,-0.072064675,0.05213715,-0.0076082055,0.01068753,0.001698989,-0.042131994,-0.044388656,-0.016176123,0.06737549,0.008012045,-0.034700602,-0.01832324,-0.11700761,-0.015972788,-0.05035074,-0.050736498,-0.055255193,0.033459853,0.068172865,0.052154623,0.17250764,-0.073006235 +2.4.1.340,"The enzyme, originally characterized from the thermophilic anaerobic bacterium Thermoanaerobacter sp. X514, catalyses a reversible reaction. In the synthetic direction it produces oligosaccharides with a degree of polymerization (DP) of 3, 4 and 5. The phosphorolysis reaction proceeds to completion, although activity is highest when the substrate has at least three residues. cf. EC 2.4.1.339, beta-1,2-mannobiose phosphorylase.",384,1.0,0.0065504215,0.0015030679,-0.08896867,-0.00571476,0.023100851,0.026227394,-0.026626078,-0.009224765,0.027960552,0.11782658,-0.01651181,-0.033619825,-0.071210355,0.038419485,-0.054330464,0.026570044,-0.048159547,-0.0079644015,0.018392755,-0.0019806735,0.117671534,-0.015329685,-0.0016854175,0.025345271,0.077601776,0.0025482536,0.03632901,-0.05051744,-0.08082218,-0.024426319,-0.011462357,-0.03923946,0.08194905,-0.04885121,0.07046031,0.09130199,-0.008492862,-0.059598215,0.07390041,0.02389951,0.05824388,-0.0006850476,0.034578856,-0.019072928,-0.074026525,0.012823714,-0.034091614,0.04093281,0.052142292,-0.026375283,-0.06504131,-0.040655915,-0.06306309,-0.0045017335,0.022934137,0.030606076,-0.037996437,-0.05228561,-0.0018140753,0.037862476,0.044623367,0.015060126,0.041518807,0.044821344,0.0032055788,-0.08543297,0.061438456,-0.10972046,0.010964969,0.04173854,-0.09045674,-0.00542894,0.003876143,-0.02805036,0.07640502,-0.029879158,0.041243445,-0.04349623,0.049072213,-0.0058775623,0.02188446,-0.030547066,0.034385346,0.018361982,-0.055260584,0.011214402,0.016613184,-0.03420737,0.15555704,0.019543359,-0.0584902,0.020963827,0.0278537,-0.082011156,-0.067583494,-0.03630251,-0.008925203,0.047253333,0.0907616,-0.036100067,0.019255757,0.017370487,0.02555995,-0.11118968,-0.02299547,0.039676853,0.021860382,0.07332184,-0.0022399058,0.069736004,0.011147252,0.004146537,0.07621214,-0.04334606,-0.05268597,0.072349325,-0.009200669,-0.1073584,-0.07953636,-0.008419251,0.0015006799,-0.072754405,0.060223106,0.027551541,-0.1256971,0.032112982,-0.079974726,1.7269935e-33,0.057845816,0.038296025,0.042950425,-0.028801454,0.06797703,0.002676721,-0.027588475,-0.034642484,-0.07825795,-0.069679275,-0.042116396,-0.038643572,0.028811006,0.09195932,-0.012417325,-0.006594084,-0.0052274023,0.08154575,0.0020760775,0.07435832,-0.03794863,0.06876698,-0.0007889885,0.03428111,0.09102259,0.073473416,-0.03860106,-0.015957503,0.047933675,0.003051553,0.09615868,-0.050095834,-0.16567689,-0.016166648,0.03345164,-0.0122933015,-0.07514233,-0.010669969,0.025064502,0.028647874,-0.017210955,0.05726841,0.005649407,-0.008348154,0.018283384,0.027008174,-0.0010655983,0.08658684,0.02370537,0.06742687,-0.0037507627,-0.003724096,0.05245179,0.023277422,-0.033146597,0.045858596,-0.020573206,-0.031012531,0.054431323,0.021728344,-0.010809832,0.07648136,-0.03293752,-0.023077676,-0.03920507,-0.008058415,0.009328608,-0.039663255,0.042149417,0.023511698,-0.071472466,-0.0385769,0.0034862808,0.019990792,0.002645596,-0.04745344,-0.054333795,-0.07368261,-0.0068833367,0.0050071557,0.030518766,-0.0023753445,0.024495468,-0.05292909,-0.029591223,-0.011606213,-0.03447399,-0.03146546,-0.021764206,0.09254803,-0.00082174176,-0.10281619,-0.069215216,0.05124955,-0.03648868,-2.8976821e-33,0.12976559,-0.093782805,-0.0019365586,-0.055144858,-0.10222566,-0.002047826,0.046651393,-0.017299386,-0.023874918,-0.030683367,0.08852901,-0.019872982,0.044584997,0.001766527,0.006587533,-0.025836935,0.023435622,0.10048036,-0.04267675,-0.0021019266,-0.015347566,0.084963866,0.01940364,-0.038554307,0.06202279,-0.008854497,-0.023879744,0.08298084,0.03729503,0.008589305,-0.02101658,-0.024846701,-0.054227833,-0.040715706,-0.044199195,0.017730065,-0.08799767,-0.003460718,0.096609056,0.029664874,0.027490359,0.0017971307,-0.011305514,0.009129192,0.014672571,0.03477019,-0.0853995,0.07030004,-0.0038117154,-0.013333449,0.006286239,-0.015212638,-0.020156195,0.03215786,0.0140531575,0.05490749,-0.0073033194,0.04852774,-0.04860795,-0.063210756,-0.044908166,-0.036499508,0.15772016,0.02109118,0.031554632,0.12988134,-0.052069888,0.043142777,0.016708367,-0.03589032,0.010080278,0.043633316,-0.02277846,0.04002418,0.03321591,-0.013293488,-0.12224728,0.0009015512,0.0060822056,0.018151538,-0.021034472,-0.0025035234,0.06947295,-0.027214132,0.024914186,-0.11020101,0.09678467,0.062077582,-0.032612886,0.09681822,0.02500486,-0.043044172,-0.013685804,0.08618795,0.07738052,-3.949384e-08,-0.008519198,-0.024785906,0.056585915,-0.06710892,-0.020511102,0.04184283,-0.01169775,-0.06642803,0.040056374,-0.053586733,0.019065442,0.08764168,0.02927857,0.03909171,0.02686552,0.0065140272,-0.072478615,-0.015017063,-0.043851517,-0.024489567,-0.086919285,-0.013630539,-0.12079126,0.05352044,-0.0013103822,0.009885533,0.034357898,-0.03562009,-0.07037329,0.0018077672,-0.037882086,0.024465555,-0.049873676,-0.036037583,-0.028203748,-0.01180914,-0.058107566,-0.05880798,-0.020420847,-0.021763805,0.035013136,0.0054898905,-0.046068896,0.032271788,0.006334326,0.023359286,-0.025449503,0.008363549,-0.070401534,0.028133444,0.029151691,0.009887722,-0.06301473,-0.01841026,-0.11214911,-0.039402563,-0.04157434,-0.03874141,-0.07212214,0.016916143,0.05169591,-0.014264756,0.17325476,-0.050197452 +2.4.1.341,"The enzyme, characterized from the bacterium Escherichia coli O55:H7, participates in the biosynthesis of an O-antigen. The reaction involves anomeric inversion, and does not require any metal ions. The enzyme is highly specific towards the acceptor, exclusively recognizing lacto-N-biose, but can accept GDP-L-fucose as the donor with almost the same activity as with GDP-beta-L-colitose.",384,1.0,-0.023099098,-0.009553389,-0.033384483,0.06571269,0.04794422,-0.019352727,-0.0094851125,0.024229733,0.025294598,-0.032562103,-0.0091782855,-0.04571416,-0.10587292,0.054489397,-0.060094923,0.0010882508,-0.015735077,0.005213988,-0.0072291526,-0.052934505,0.06025661,0.009176385,-0.0030244694,-0.01293305,-0.0064572864,-0.017971672,0.052972328,0.01653579,-0.025760915,-0.08975373,-0.06212474,-0.070366226,0.11858404,-0.019930102,0.0286551,0.04124922,0.049881253,-0.07414261,-0.024829932,-0.025387848,0.02535455,-0.043363262,0.040907476,0.008882671,-0.006300267,-0.047625817,0.076148055,-0.0018121343,0.0026413677,-0.01389433,-0.07444311,-0.03973069,-0.044723734,0.029635215,-0.014350845,0.054201767,-0.020645961,-0.12772267,0.017163998,-0.020579483,0.008634381,-0.013327112,0.05132722,0.03537801,0.055529773,-0.109798566,0.050636757,-0.09304203,-0.068421274,-0.0769555,-0.025240941,-0.07728966,0.042846303,-0.0024792475,0.07711704,0.02277181,0.020457685,-0.031165805,0.10360041,0.00634863,0.06739202,-0.030825298,-0.01029971,0.09136236,0.014749355,-0.012702168,-0.035153806,0.075468205,0.031912003,0.01124997,-0.042013593,-0.08224421,0.0103474,-0.11304633,-0.033681985,-0.0040287063,0.040772773,0.03870222,0.056556866,0.017834762,-0.061587412,0.089102834,-0.017228607,-0.039826486,-0.06352659,0.012792657,-0.019906718,0.11275381,0.06221989,-0.028945107,-0.004662352,0.004538554,0.07662464,0.01369138,-0.04009428,0.03907699,0.0065337317,-0.09949949,-0.03996311,0.0405427,0.0062611834,-0.019059466,0.049487412,0.09647756,0.005149174,0.045767732,-0.086453244,-2.772565e-34,0.04257527,0.0037598626,0.058533028,-0.061381575,-0.026498942,-0.042521212,-0.037696306,-0.08344253,-0.008510213,0.02556258,-0.10538082,-0.06388665,0.089328684,0.03756742,0.010313571,0.0024053971,-0.021772616,-0.0062726713,-0.004763346,0.0628574,0.017374048,0.04553781,-0.06040274,0.037375286,0.06101549,0.08957476,-0.05141751,0.02145386,0.039322928,-0.008107698,0.03565609,-0.08561866,-0.044239383,0.017305588,0.07457247,-0.041076005,-0.013751969,-0.0016021875,-0.003319449,-0.009883994,-0.01699584,0.06878643,-0.071920395,0.051493097,0.06647405,-0.023635449,-0.009098085,0.020997638,0.044336732,0.11456578,0.03635099,-0.03431459,0.0052901856,-0.10966345,-0.0308301,0.013987703,-0.05274884,0.07177949,0.06573312,0.05052886,-0.026574599,0.01971368,-0.053228866,0.03454782,0.0077863554,0.055859603,0.02173297,-0.06087652,-0.0006875468,0.094305165,-0.07076222,-0.002306728,0.01786896,0.019389339,-0.019883366,-0.03523447,-0.03907223,-0.05056914,0.070136346,-0.029981455,0.01081906,-0.074569665,2.3363851e-05,0.009028261,-0.0669443,0.0077807033,-0.07070985,-0.04496586,0.017154308,0.024936939,0.035714168,-0.028256962,-0.048585728,-0.0029508707,0.043843284,-1.7468256e-33,0.07481851,-0.07887243,0.027481334,-0.050454922,-0.07730007,0.04772239,-0.017708998,0.019242065,0.017698813,-0.034862265,0.07846811,-0.025961643,0.062236395,-0.045613613,0.002143616,0.05381428,-0.08309959,0.068427026,0.013530868,0.044110574,-0.024654737,0.07541777,0.015785448,0.0056974506,0.06649923,0.062151987,-0.07866949,0.04151516,0.11319414,0.020104066,-0.005217572,-0.0013355118,0.0031794987,-0.08141115,-0.041748658,0.035438854,-0.021102924,0.007800893,0.066067874,0.017737594,-0.020578936,-0.017315589,0.012098161,0.07355295,-0.035453312,0.09266054,-0.049663685,0.026023839,0.089958176,-0.08614893,-0.0045414213,0.018135158,-0.029696975,-0.031413693,-0.0027599006,0.07544352,0.046966378,-0.034712054,-0.027552849,-0.012141539,0.012403861,-0.08907083,0.10314491,0.008457817,0.014934294,0.041332994,-0.023238147,0.0094824685,0.02624382,-0.09203534,0.028444488,0.0030537432,0.0010389308,0.027764574,0.06324295,-0.05256044,-0.07805096,-0.042756967,-0.00424823,0.07438289,-0.06296681,0.052041933,-0.0061835214,-0.017517287,0.07086128,-0.07527753,0.01411572,0.034579277,0.025148524,0.037395623,-0.04234971,-0.018323576,-0.057686802,0.03836953,0.0023522724,-4.05629e-08,0.0144048305,-0.122096226,0.07318192,-0.083570905,-0.014293864,0.09676613,-0.043635197,-0.0379137,0.040903762,0.0035623007,0.018465044,0.15143156,-0.027945394,-0.018417103,0.042408746,-0.005451471,-0.025104636,-0.012799311,-0.038621385,0.041042306,-0.03111812,-0.05698494,-0.06850016,0.009370576,0.051960018,-0.06642644,-0.048547804,0.06690978,-0.056538407,-0.07928191,-0.029007193,0.023661653,0.011777617,0.003467851,-0.09046952,0.016103392,0.0004531705,-0.06153971,-0.033487026,-0.0055435067,0.04198712,-0.010298946,-0.08972648,0.0019505509,-0.009989748,0.0557033,-0.011512467,-0.028881086,-0.039216585,0.00048482406,0.04035056,-0.08545027,-0.010221435,-0.0070304982,-0.044761095,0.008180192,0.03753886,-0.055186626,0.08685033,-0.052482817,0.09973561,-0.0036461614,0.20256253,-0.084972665 +2.4.2.58,"The enzyme, found in plants and mosses, catalyses the O-arabinosylation of hydroxyprolines in hydroxyproline-rich glycoproteins. The enzyme acts on the first hydroxyproline in the motif Val-hydroxyPro-hydroxyPro-Ser. ",384,0.99999994,-0.06887888,-0.050003886,-0.027988818,0.020654328,0.007925586,0.06774339,-0.022160802,-0.0075202617,0.021114845,-0.055513006,0.031125648,0.052466538,-0.01797798,-0.03736939,-0.058438078,0.09395877,-0.053991366,0.038763203,-0.058282737,-0.038438614,0.054441527,-0.034225825,0.019436602,0.018338349,0.056360826,-0.024316177,0.008989324,0.014546462,0.0126271555,-0.10056368,0.024121813,-0.0040600565,0.017463194,-0.023537893,0.042547666,0.07117878,0.043517392,-0.09636871,0.015026759,0.028089684,0.063113615,-0.06015043,-0.04464657,-0.06303956,-0.024077369,-0.021863151,0.035872363,-0.0007208996,0.054775372,0.023234675,-0.08034546,-0.087220035,-0.07506322,0.024577059,-0.010297798,-0.034747917,0.056063965,0.032327216,-0.022000922,0.030815886,-0.0013338419,0.028473128,-0.0064891726,0.028935364,-0.014948339,-0.039637282,0.046450697,-0.014215342,0.04805282,-0.048990615,-0.0423554,-0.04142906,-0.028858688,0.069443166,-0.03410411,-0.0043568593,-0.078810394,-0.025472695,0.06259957,-0.025764529,0.015443467,0.019858833,-0.016843565,0.0645683,0.0065032262,-0.0041425456,0.013819254,-2.3334573e-05,0.10733605,0.0373516,0.0036039427,-0.034289367,-0.016560767,0.0089938985,-0.026038053,0.03041497,0.058579393,-0.015267416,-0.02316443,-0.04955352,-0.021265551,-0.004005084,0.035738718,-0.052358534,-0.038108304,0.064187,-0.02416547,0.059937716,0.019374583,-0.031121016,-0.036728542,-0.03900794,0.030427162,0.029720327,-0.052138694,0.06939874,0.023838349,-0.09140478,-0.045686364,-0.064258374,-0.014433537,-0.042148616,0.050704613,0.0895689,-0.062973574,0.074626796,-0.078328736,1.5023555e-33,0.06022774,0.059362985,0.027930772,-0.0132836215,-0.04341464,-0.061853006,-0.08014018,0.05631543,-0.0889371,-0.06591917,-0.061697062,-0.05968026,0.009383682,0.063932,0.02792727,-0.10503948,0.03187908,-0.04075915,0.010601075,0.02682754,-0.01589888,-0.013239921,0.0021281817,-0.013864298,-0.012610611,0.025066646,0.060688652,-0.012593266,0.037287567,0.023738058,0.046985403,-0.16335957,-0.036287572,0.046619095,-0.0031485548,0.005396319,-0.023805717,-0.06272415,0.028017739,0.09323703,0.0032318316,-0.019977938,0.054855432,-0.038687598,0.054142132,0.004509699,-0.031105572,0.10357406,0.029952032,0.045471545,0.031007644,0.048654534,0.057648174,-0.0014886752,-0.017287957,0.0706328,-0.08414972,0.0054881787,-0.037843216,0.05187695,0.009903303,0.030640421,0.0021323285,0.011114291,-0.025178904,0.02827376,-0.01372353,0.029808844,-0.0075416956,0.090567105,-0.047813497,0.008133181,0.06547159,0.061538864,0.036834028,-0.028580252,-0.009724437,-0.018548753,0.058802478,0.009942148,-0.008755902,0.049136885,0.03000306,0.06580135,-0.10601748,0.03638233,0.051457305,-0.025167055,-0.05961773,0.07502212,0.04358743,-0.03334253,-0.00966217,-0.0036697828,-0.023564538,-3.1061255e-33,0.0957123,-0.111818284,0.06836046,-0.094838515,-0.06524937,-0.00858289,0.033538572,-0.01542508,0.064181454,0.09114349,0.025188275,0.0072362395,0.036863018,-0.11260811,0.034853626,-0.05629534,-0.028343681,0.019346518,0.0132161975,0.0015480483,0.015393553,-0.020996762,0.04592922,0.021529898,-0.0134220235,-0.035420295,0.047184136,0.053909753,0.010421595,0.11431697,0.017194921,0.0046915435,-0.078845955,-0.024257328,-0.028731486,0.09784099,-0.09616126,0.017312312,0.029846761,-0.03824488,0.008587302,0.016644439,0.041895416,-0.052641198,0.042770687,0.07013497,-0.08883018,0.064717956,-0.013934972,-0.038116656,0.028994592,0.088559546,0.0059834314,0.065368235,-0.016318534,0.04853115,-0.013928769,0.031901333,-0.06727497,-0.05419412,-0.028379245,-0.036393568,0.020520097,-0.011789105,-0.0051963027,0.06754669,0.034677155,-0.031228088,0.037863433,-0.016461125,0.08235977,-0.01156211,-0.07446953,0.04847834,0.0014309164,0.039164186,-0.08780979,-0.04112881,-0.104782045,-0.027486984,0.060439173,0.010438946,-0.032177426,-0.11122832,0.011566945,-0.03005186,-0.025457636,0.14035735,0.05614215,0.047166303,-0.029670527,-0.018742116,-0.13434982,0.019094285,0.055828664,-3.2396354e-08,-0.09255602,-0.047446508,0.12559249,-0.05482955,-0.022270171,0.049139448,0.0103211785,-0.0054517593,0.015507724,-0.06670968,-0.028128853,0.067322105,-0.033650137,0.014220585,-0.008231683,-0.018154563,-0.033750154,0.048263803,-0.018257461,-0.013726787,-0.062359728,0.012047467,-0.07858004,0.06340781,-0.057757366,-0.02306916,0.0022231347,0.052306637,0.01877544,-0.013477169,0.08445292,0.030400816,-0.001471046,-0.06365737,-0.06193057,-0.018992176,-0.014635795,0.00088888925,-0.028104108,0.043138225,0.033823337,-0.030082257,-0.011701147,-0.031467225,0.033083767,0.02540502,-0.028475616,0.010313062,-0.014209936,0.116559625,0.10951429,-0.017356608,-0.026431687,-0.08810075,-0.1278242,-0.044463623,-0.013266051,-0.11626203,-0.041576307,-0.056760192,-0.028631095,-0.022579933,0.22668657,-0.027649371 +2.5.1.132,"The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). The human sialic acid synthase (EC 2.5.1.57) is also able to catalyse the reaction. Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.",384,1.0,-0.03811008,-0.108081706,-0.07247039,-0.020808296,0.0010686149,0.07233246,4.2106847e-05,-0.018136265,0.023932604,0.015877748,0.025649037,-0.022087146,-0.078103736,-0.002153218,-0.068925075,0.0057151094,-0.033518486,-0.01751734,-0.009734317,0.034148727,0.10021377,0.0055705504,0.003886859,-0.0039032442,0.0734722,-0.028392661,0.026692249,-0.044994637,-0.034014605,-0.057730924,-0.016570231,-0.08696567,0.118668415,-0.05771744,0.07416148,0.016092036,-0.038016424,-0.010994645,0.066024676,0.022526938,0.030923413,-0.017352493,-0.007788908,-0.027186112,-0.0174266,-0.014091841,-0.045855235,-0.0019386131,0.043111637,0.023177927,-0.024836961,-0.07016891,-0.026785636,-0.031780627,0.056126613,0.061806895,-0.05985174,-0.02278775,0.051330782,0.008950473,0.08755247,0.018988954,0.044220865,0.033150136,-0.014899789,-0.035630975,0.10673753,-0.033756122,-0.0102497125,-0.023072908,-0.0055194213,-0.054847468,-0.06328601,-0.006118584,0.02369995,0.017944038,-0.016247055,-0.0365963,0.0032513062,-0.009024696,0.060830563,0.059693687,-0.04195312,0.008162764,-0.040592823,-0.042575557,0.022083558,0.053373113,-0.047853395,-0.044313237,0.025008084,-0.04268867,0.020418944,-0.08615161,-0.06592859,0.07150443,0.06394939,0.027816763,0.043673113,-0.041962147,-0.056198265,0.016057063,-0.004344272,-0.10458182,-0.022916768,0.046301678,-0.014532184,0.052075688,0.053851973,-0.017518764,-0.011537988,0.0360312,-0.022061449,0.0558787,0.003862427,0.038439143,0.08281587,-0.13823423,-0.055463932,0.012957307,0.035084147,-0.092936546,0.06288562,0.07555764,-0.031951085,0.104263455,-0.057542905,6.392654e-34,0.09986076,-0.00145261,0.020345032,-0.06625019,0.049284358,-0.021190489,-0.11224302,-0.038831014,-0.05533164,-0.053625587,-0.0901626,-0.08326447,0.029385896,0.09792658,-0.007123072,0.096032165,0.03032571,-0.014832787,0.06257693,0.0024023305,0.05376939,0.005795834,-0.02061069,-0.023389112,-0.00093816227,0.086579025,-0.010409131,0.05523678,0.06887826,-0.011154571,0.036751986,-0.10955625,-0.07309362,0.026388552,0.05419953,-0.0113200145,-0.06672148,-0.020239461,0.016945336,0.07592704,-0.018623767,0.031051235,-0.0024828746,-0.018757507,0.044527017,0.022492027,-0.029272404,0.034540776,0.033027098,0.022504723,0.008537001,-0.007909082,0.03689165,0.02599297,0.007910502,0.061202127,0.014277195,-0.0365556,-0.004407834,0.021782333,-0.0016907579,0.017542368,-0.024365272,0.06664599,-0.006722547,0.0110613145,-0.06842429,0.01527542,0.032600075,-0.035434105,-0.048710264,-0.026575524,0.0009742627,0.017443635,-0.03651391,-0.043942142,-0.0011092804,-0.020891553,0.012720305,0.019934215,-0.010220352,0.04915935,-0.07568392,-0.03799654,-0.031269647,-0.0041136197,-0.087759405,-0.04534909,0.017983636,0.04433231,-0.05045021,-0.05836623,-0.091983184,0.02054331,-0.044855766,-3.4588855e-33,0.115380846,-0.07898493,0.07237545,-0.07041323,9.860257e-05,0.13218932,0.0580929,0.05798381,-0.010260262,-0.0002898276,0.047411855,0.0059968913,0.020100845,-0.053298954,0.049259394,0.03393612,0.02970035,0.08502229,-0.022638846,-0.06790644,0.04476991,0.013163291,-0.01609661,0.046784937,0.043981034,-0.021086263,-0.035607263,0.053441938,-0.034586277,0.09820525,0.00043932354,-0.013931975,-0.09804871,-0.07385667,-0.008111114,0.012999276,-0.041413754,0.010753969,-0.010703978,-0.00907554,0.018115034,0.057498787,0.047871903,0.055813752,0.07842814,0.08854624,-0.050675847,-0.02939223,0.02619457,-0.029839369,0.07158677,-0.046187192,0.031700827,0.023095971,0.05601713,0.023832632,0.0714382,0.109476745,-0.028622901,-0.06372998,-0.090628855,-0.09834748,0.06350078,-0.07622941,0.022524565,0.080020085,-0.040208593,0.0632169,0.024050783,-0.060572088,0.047520243,-0.07093355,-0.032788806,0.05335578,-0.06472343,-0.023944719,-0.12386759,-0.028546384,0.050999165,0.018949749,0.06136858,0.01916755,-0.026513943,-0.032187272,-0.017233673,-0.042354148,0.08877674,0.10049521,0.0012946185,0.016337879,-0.09505462,0.007208313,-0.11946238,0.020388896,0.067973174,-4.057172e-08,0.04296936,-0.04537201,0.019084912,-0.0931268,-0.028488172,-0.0041504703,0.002891581,-0.012332732,0.026005322,-0.08964511,-0.01303709,0.090007,0.00023896404,0.017526126,-0.0056392755,0.027215054,-0.006387377,0.0055860677,-0.027605781,0.008279003,-0.084112465,0.062351786,-0.10868746,0.046519097,-0.017577667,-0.07009492,0.00454448,0.047266163,0.009375555,-0.006582956,0.027762244,0.004004813,-0.076607406,-0.00062831835,-0.038422357,-0.0064846426,-0.048847802,-0.056651313,0.054975525,0.006108377,-0.03027079,-0.0019852659,-0.033230726,0.01149139,-0.06325699,0.009900114,-0.030660154,0.050464414,-0.065209836,0.05155098,0.0058917226,-0.10580534,-0.054869916,-0.0463001,-0.130598,-0.023222608,0.010893758,-0.07106067,-0.0075462093,-0.005738424,0.03072693,0.012183843,0.18508738,0.03526326 +2.7.1.209,"The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol.",384,1.0,-0.075129405,-0.077420525,-0.028689653,0.011999849,0.056830738,0.0094056865,-0.04278599,0.114976265,0.035020925,0.015328111,-0.050151877,0.009671432,0.020623755,0.02543627,-0.056237143,0.07134395,-0.02915209,-0.012844585,-0.047583982,-0.024194751,0.071281,0.047818765,-0.06464839,-0.05806145,0.068578385,0.009001114,-0.014751277,-0.01242013,-0.045373682,-0.07417523,-0.016132476,-0.024490064,0.074449115,-0.066859886,0.12768133,0.05018314,-0.080152124,-0.05537737,0.079476856,-0.08989333,0.019578902,-0.037650704,-0.047779903,-0.040995434,-0.07171395,0.01454998,-0.020892177,0.044042345,0.007859961,0.055395044,-0.09763849,-0.034051195,-0.007675021,0.05074352,-0.06889678,0.003732992,0.0023798868,-0.037929267,-0.010237577,0.0021517938,-0.011399713,0.017806936,0.0011830814,0.033432443,0.0049619577,-0.09196616,0.0003709606,-0.021081513,0.011880427,0.05028333,-0.08339043,-0.036737464,0.0041171815,0.12262864,0.06626242,-0.063311026,0.0057311105,-0.024212051,0.031633567,0.03879712,-0.022611354,0.022622969,-0.029432934,0.0148489885,-0.0017834472,-0.024895351,0.06331564,-0.024370816,0.07021516,0.013951936,0.028826367,-0.037655994,-0.03446608,-0.0620896,0.008681538,-0.002681779,-0.005476302,-0.009643656,0.020908859,-0.03129948,0.013427707,-0.0075586163,0.021422075,-0.11842142,-0.0582968,0.009188182,-0.061238028,0.08505942,0.06287474,-0.058388453,0.037266526,-0.0100964075,0.05220083,0.01725181,0.0056854556,0.036896076,0.096371986,-0.041939333,-0.04588331,-0.01877825,0.010637731,-0.075062886,0.053593375,0.056373958,-0.072626784,0.03288311,-0.080726355,-2.499382e-33,0.03469985,-0.061143942,-0.03113692,-0.05260607,0.031356487,-0.09111987,-0.05757119,0.012986284,-0.041633733,-0.014191901,-0.011418632,-0.08908794,-0.0054188524,-0.0057589645,-0.071997955,0.03324343,-0.019747384,0.032268584,0.008128638,0.047484655,0.028733702,0.04232221,0.0051717954,0.067604035,-0.008787069,0.10211843,0.03668177,0.062460303,-0.0016245084,-2.8902174e-05,0.063942626,-0.025350671,-0.06439731,-0.020497521,0.06434279,0.031467527,-0.0107949,-0.0026754788,0.034625027,0.043119855,0.041320175,0.013235792,-0.0053858305,-0.026897956,0.07464317,-0.06516334,-0.010894766,0.067657195,-0.04771874,0.0024744973,0.067756504,-0.12374357,0.053491816,-0.050314788,-0.029862056,0.029573128,-0.00515797,0.040662587,0.020736085,0.025934465,0.009288389,0.048800815,-0.03856353,0.0956656,-0.022985324,-0.05430019,-0.025356662,0.031599935,-0.019499453,0.081160955,-0.0255255,0.03359516,-0.00754825,0.015225039,0.08094116,-0.092218526,-0.07496199,0.05152777,0.02275169,0.010965744,0.049224615,-0.015310116,-0.063735746,-0.010944556,-0.059505247,-0.049158964,-0.014624367,-0.08437801,-0.007209851,-0.01563173,0.002804056,-0.08643967,-0.052819185,0.08997248,-0.06859047,-1.1722158e-33,0.047475316,-0.10024189,0.12538752,0.045978885,-0.06393879,0.015913304,-0.0035892143,0.09133296,0.0015539547,0.008542163,0.05831554,0.0013960428,-0.016439825,-0.019944182,0.03340247,-0.010624071,0.03299419,-0.07352516,-0.09748552,-0.012611959,-0.064218745,0.040657938,0.08228817,-0.077793665,0.022532219,0.01595894,-0.031024246,0.07430466,0.0697594,0.058929935,0.010033271,0.031533174,0.009842682,-0.112976804,-0.06264758,-0.010097981,-0.037672844,-0.028895037,0.04949035,-0.028514,0.050620597,0.036622513,0.045487445,0.03774567,-0.023851018,0.009162915,-0.08868087,-0.032605078,-0.00064765767,-0.07806299,0.009749345,-0.009378058,0.0419386,-0.004108617,-0.021360092,0.06182457,0.0071772905,-0.015144818,-0.042703737,-0.02196381,-0.07437027,-0.06646002,0.0628717,0.061822765,0.09624627,0.07515472,-0.0026109328,0.1049702,0.027538346,-0.046761405,0.077628076,0.005825432,-0.005139895,0.007456147,0.010383954,-0.039460894,-0.08885107,0.066280976,-0.0061950395,0.0052728686,-0.04360338,-0.060989797,-0.03505437,-0.13769485,0.0066894065,-0.074047886,-0.009898192,0.13217774,0.016492667,0.053082656,-0.069649436,0.02274177,-0.04040965,0.03783552,0.01812944,-2.449036e-08,0.006085651,-0.054811995,-0.01812462,0.0070935003,0.032198552,0.04235124,-0.06142496,0.03285509,0.06784479,0.07745272,-0.04303224,0.05510416,-0.033368185,-0.071390726,0.03408887,0.039918743,-0.049391914,-0.054159716,0.03156812,0.014360693,-0.033123564,-0.011505425,-0.017467435,0.06968844,0.03467409,-0.016479079,0.03108572,0.014527844,-0.039907392,-0.02944413,-0.056217898,0.09297723,0.00071377127,-0.022744918,-0.1066134,0.02227422,-0.04108062,-0.109144695,0.02668213,0.08590523,0.06351778,0.13516062,-0.07429697,-0.006360748,-0.026292505,0.017549776,0.049281884,0.0024990265,-0.05659165,-0.03865737,-0.054501716,-0.008883926,-0.09911442,0.014426853,-0.052627232,0.032566346,0.030784778,0.0024071939,0.007436635,-0.035590943,0.06839497,0.039686434,0.12481205,-0.009901103 +2.7.1.210,"The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of erythritol and D-threitol.",384,0.99999994,-0.06652581,-0.05935665,-0.052097417,0.024532039,0.056198608,-0.016768929,0.0025218986,0.109264486,0.039458077,0.036876008,-0.07365263,0.022944877,0.023522299,0.029741522,-0.041789997,0.07194958,-0.006214378,0.048215862,-0.07472103,-0.023204334,0.041724823,0.0685667,-0.020144826,-0.059792433,0.04934773,-0.0030596643,0.015355981,0.037061337,-0.06401824,-0.092092305,-0.011977546,-0.056491587,0.095379494,-0.03286338,0.11649436,0.044547535,-0.06777855,-0.06533697,0.04941189,-0.10749425,0.04005961,0.0058411537,-0.019391041,-0.008577796,-0.08262518,0.020443525,-0.051413577,0.045873486,0.039455,0.035226543,-0.062804535,-0.041843716,-0.018441476,0.03442593,-0.019552354,0.018955601,0.022372494,-0.072540864,-0.033002928,-0.0048594107,0.047074523,0.0054189656,0.029242722,0.0043100007,-0.013615605,-0.06853226,0.018336749,-0.054232515,0.00049091136,0.031942274,-0.13067478,-0.062310155,-0.053080764,0.14995708,0.06914726,-0.06576135,-0.0118050445,-0.01681105,0.048365314,0.013999716,-0.03197125,0.022190427,-0.010790212,0.014661532,0.019674089,0.019922698,0.052269053,-0.02041503,0.06370083,0.013398821,0.05175612,-0.053650867,-0.02260649,-0.06317986,-0.011968782,-0.013213269,0.006995895,-0.01003557,0.004771413,-0.015087484,-0.011072108,0.00096422766,0.019723708,-0.11917689,-0.0698859,-0.0072731506,-0.06605234,0.048649423,0.029737338,-0.038791597,0.014694039,-0.022074725,0.031485613,0.037376523,0.008030322,0.056163482,0.105250716,-0.007623852,-0.09376777,-0.0036690969,0.003630345,-0.05345475,0.05510963,0.066638865,-0.06507527,0.0010893372,-0.06596342,-6.113042e-34,-0.0049619214,-0.08961947,-0.054566022,-0.0121191535,0.027938284,-0.058420368,-0.058070067,0.022223674,-0.012423027,-0.021518337,-0.03990443,-0.091704704,0.051584087,0.017977202,-0.07920354,0.06889432,-0.012512263,0.028884506,0.04625467,0.0518266,0.049535707,0.011733194,-0.002514813,0.04013683,-0.02219375,0.091610394,0.0013280504,0.07460221,0.06717924,-0.01353949,0.06450262,-0.057709195,-0.06343226,-0.0057062223,0.042340267,0.029375376,-0.0061653918,0.018085325,0.02602084,0.028483639,-0.0114938915,0.006508434,-0.021531753,-0.01533494,0.076153494,-0.05035918,-0.008553872,0.08742184,-0.0020810456,0.012584184,0.02997829,-0.08308458,0.11760149,-0.050211094,-0.03373989,0.012383166,0.010695043,0.031181397,0.045202993,0.036843937,-0.019004898,0.058622204,-0.037606798,0.08203085,0.0039646374,-0.012620373,-0.0127156535,0.038148243,-0.041171152,0.09672421,0.0068769935,0.007770071,-0.021703446,0.02708619,0.024776623,-0.10276057,-0.06931515,0.038831778,0.01753113,-0.0044810674,0.0063937465,0.003954183,-0.08271318,0.007965412,-0.045361463,-0.03576116,-0.050508138,-0.07494033,-0.025265837,-0.006769319,0.011507234,-0.08732116,-0.103419885,0.09063193,-0.025831202,-2.1663413e-33,0.05920881,-0.060864054,0.04800864,0.05300869,-0.029755384,0.0080630565,0.020445202,0.11294834,-0.010808677,0.024527526,0.08904026,-0.006660185,-0.059051342,-0.02350206,0.023898566,0.0005977483,0.008325425,-0.02369436,-0.08563541,0.0007354123,-0.0857508,0.07173634,0.04546749,-0.09300748,0.017833015,0.0312123,-0.039639153,0.051977772,0.018320033,0.048928596,0.03255776,0.025346117,-0.0065323007,-0.09494939,-0.07391588,0.007828611,-0.039690234,-0.04816382,0.013065687,-0.037381988,0.063973375,0.076786034,0.02893023,0.04737103,0.011474108,0.03234956,-0.14288794,0.036211018,-0.0012419622,-0.07708543,0.0037355567,0.014756511,0.08312715,-0.003782171,-0.011514385,0.046496134,0.080106124,-0.02094754,-0.05760847,0.017639795,-0.1082672,-0.041246384,0.07247311,0.062089812,0.079733446,0.057928897,-0.0005231355,0.11525107,0.028443871,-0.032976888,0.059734724,-0.008761153,-0.01645074,0.0014754751,-0.03259696,-0.035856664,-0.026607078,0.098315135,0.01799224,0.02115428,-0.027612666,-0.04961399,-0.036805738,-0.1253959,-0.03152016,-0.08848906,-0.024698418,0.12348847,0.021531826,0.062377386,-0.029467253,0.012015685,-0.06791597,0.053817194,0.030176423,-2.7470747e-08,0.030429993,-0.058030356,0.003896363,-0.019915719,0.039817516,0.020902961,-0.040720224,0.073959485,0.048165113,0.0676487,-0.041693565,0.05386746,-0.042435654,-0.05541415,0.04912155,0.050157156,-0.042341664,-0.0685726,0.013885736,0.0020102728,-0.024741543,-0.03542406,-0.029506287,0.055407044,0.055181988,-0.060821347,0.019766012,-0.01548113,-0.049489006,-0.015910383,-0.037799396,0.06269305,-0.010090805,-0.0051247757,-0.105592385,0.0015124026,-0.063730344,-0.117595896,0.015612949,0.07894296,0.023592962,0.09591507,-0.06577312,-0.020537391,-0.023682907,0.023920711,0.013411451,-0.037015337,-0.025105482,-0.03593533,-0.0449913,-0.02612727,-0.05879801,0.0051218346,-0.1052821,0.057199974,0.01763017,-0.0018945914,-0.0009916673,-0.021892559,0.064364195,0.0135689955,0.12256343,0.006251196 +2.8.3.24,"The enzyme, characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway. The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate.",384,1.0,-0.06594374,-0.019156646,-0.095460355,0.0045100963,0.11259616,0.057412133,-0.08005053,0.07508533,0.060940553,-0.01332382,0.01183746,-0.08172644,0.015527933,0.02903783,-0.030074427,0.00096582045,-0.046580292,-0.06357449,0.012716304,-0.09179781,0.047444206,0.050300404,-0.009980854,0.02548249,0.06529371,0.017932463,0.057615604,-0.015160474,-0.014315578,-0.056372408,0.038527574,-0.05585987,0.09141476,-0.015963724,0.055020787,0.07743217,0.0028034842,-0.012185929,0.10292532,0.020415042,0.028112601,-0.031806376,-0.02402088,-0.007143055,-0.04284844,0.008841853,-0.013665801,0.06708955,-0.02988236,0.010331392,-0.0090081,-0.03446095,-0.024844486,0.010550036,-0.0447421,0.07253073,0.0018755109,-0.040032305,-0.004053914,0.002997053,0.003573948,0.006233485,-0.029578544,0.055264477,-0.041669566,-0.09911808,0.0032646356,-0.06120675,0.0033838418,-0.03864041,-0.03958428,-0.08754723,0.00083267374,-0.00865311,0.11715517,-0.026512556,0.0005172233,0.0044410583,-0.0046920297,-0.051783826,0.03210326,0.0045567304,0.022555405,0.073212154,0.014545009,-0.046512272,0.08486129,-0.056436364,0.08354294,-0.029305687,0.014596528,-0.029989196,-0.040985752,-0.05688568,-0.07755424,0.0077955336,0.021670891,-0.027669162,0.038427144,-0.011897555,-0.009446645,0.05907774,-0.054964475,-0.057609513,-0.07855553,-0.017050512,-0.005572689,0.11290186,0.081033364,-0.039225485,0.042629696,-0.015468959,0.045844566,0.007091784,0.012965524,0.01338033,0.056405015,-0.06150798,-0.048976574,-0.019914472,0.02915423,-0.029232087,0.03561566,0.092369534,-0.04926861,0.05584438,-0.10768414,3.863121e-33,0.0902635,-0.0074185673,-0.013760219,-0.015209714,-0.009956053,0.01996619,-0.07622984,0.0416293,-0.016035296,-0.017882941,-0.035787992,-0.102270655,0.02189283,0.051530868,-0.069448955,-0.037541464,-0.03359469,0.00909597,0.0055722822,0.04033382,-0.006458187,0.031105425,0.011826736,0.06897135,0.07271365,0.06776067,0.030704292,0.034570385,0.026026992,0.004067809,-0.01806848,-0.095723785,-0.06758935,-0.020596633,0.04644509,0.0066872323,-0.06311133,0.0077341893,-0.00906768,0.046794873,-0.0027474945,0.057991575,-0.03102744,-0.07671107,0.018912805,-0.008078983,0.02962186,0.15231183,0.0036055248,0.027762985,0.047332674,-0.04231551,0.14969335,-0.07563086,-0.061060335,0.10294521,-0.08235447,0.019176148,0.055761114,-0.009190401,0.06686397,0.091137916,-0.08056265,0.09877021,-0.01234075,0.006235288,-0.019399123,-0.040873993,0.055062372,0.09527108,-0.094780155,0.014085373,0.036213793,0.018445104,0.006557059,-0.025557492,-0.10611899,-0.02150348,0.07408215,-0.01768557,-0.006289427,-0.028754147,0.025984576,-0.055928964,-0.028742556,-0.07620462,-0.07350243,-0.078769304,-0.033537235,-0.012311654,-0.0142181255,-0.056554947,0.02445089,0.04989843,0.054066014,-4.8976847e-33,0.107340366,-0.10514669,0.06168649,-0.058837235,-0.06526021,0.03192034,0.021699838,-0.020267123,0.04373993,0.009950028,0.040607244,0.024406077,-0.0051502944,-0.056965657,0.046640985,0.020560434,0.019390315,0.076279506,-0.019357115,0.05173313,-0.027459996,0.026509821,0.037474506,-0.0717995,0.04775071,0.04069347,3.442396e-05,0.08997828,0.064595096,-0.015838696,0.008816909,0.018775918,0.015746815,-0.1115243,-0.07083977,0.08093875,-0.07372796,-0.009772099,0.02171196,-0.022373458,-0.0035303645,0.018650575,0.019455256,0.052066963,0.04925684,-0.02361977,-0.066204034,0.009948267,0.027167883,-0.074481055,-0.031824917,-0.08083956,0.009061996,-0.018371494,-0.015963169,0.040477883,-0.011795441,0.01536884,0.0029145735,-0.072082244,-0.06461613,-0.029127665,0.034134045,0.050819214,0.031194909,0.01012138,-0.06437664,0.04754153,0.07849635,-0.0046644052,0.10400652,0.021230169,-0.0016780049,0.021695515,-0.034505762,-0.02233449,-0.08533835,-0.057527907,-0.047915094,0.04276683,-0.060510546,-0.03049882,-0.017381841,-0.056079067,-0.060028903,-0.102755494,-0.0066682925,0.07270454,0.027760433,0.06680702,-0.020770852,-0.0118037425,0.035941012,0.084062494,0.066731684,-3.7889713e-08,0.021660937,-0.06532165,0.0558897,-0.0027856466,0.041291863,-0.0004799818,-0.009346063,-0.07816539,0.0040009185,-0.0519809,-0.02963623,0.046123054,0.029212322,0.010723923,0.0246253,0.066548266,-0.04507111,0.012207084,-0.027901454,0.041394133,-0.06741723,-0.042754363,-0.053398967,0.043197792,0.033740114,-0.08179808,-0.017305164,0.0060459133,-0.044211604,-0.02519168,0.03705178,0.07406645,0.010973422,-0.04488918,-0.04498244,0.0019781287,-0.03336482,-0.036038846,0.01831192,-0.0042303065,0.06295565,0.07016041,-0.061835796,0.007984536,-0.02580782,0.0075748176,-0.027214099,-0.02066427,-0.08996899,0.037118886,-0.01773967,-0.037607897,-0.05011087,0.021202724,-0.026644684,-0.0007267116,-0.008744326,-0.085818306,0.042827282,-0.09373834,0.0139675215,0.034994744,0.22177242,-0.04114285 +3.1.3.101,"The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.",384,0.99999994,-0.033391986,0.041346725,-0.16520508,-0.014067302,0.011176358,0.06632812,-0.08761877,0.070771575,0.09371555,-0.049065135,0.020304933,-0.015653556,0.019812433,0.0038618445,-0.08952559,-0.022682177,-0.03915205,0.0031212731,-0.015515301,-0.054854743,0.10089011,0.059249684,-0.0011745252,0.0008781401,0.01968139,-0.05761602,0.01527657,0.035693806,-0.048022043,-0.07430026,0.04562834,0.010529907,0.048223443,-0.043757297,0.08842224,0.089192264,-0.012082253,-0.068381496,0.1561028,0.031800356,0.0071368087,-0.058023978,-0.039972957,-0.015889358,-0.06352762,0.018284867,0.011398258,0.047118884,0.033562925,-0.0057637715,-0.068649314,-0.054201115,-0.06409468,0.033256833,0.02711098,0.034821674,-0.0020329896,-0.014903098,0.0037943064,-0.09169852,0.06571657,-0.009816365,0.017377663,0.069076814,-0.1286724,-0.03240107,-0.00870449,-0.084725454,0.027957376,-0.020438343,-0.058344044,-0.0101078665,-0.06495778,0.072738856,0.013864774,0.037635192,4.6406778e-05,-0.07174077,0.0022523287,-0.058447413,0.0681575,0.013611885,0.002249433,0.06490915,0.007853562,0.019890714,0.0064531593,-0.009830039,0.07208349,-0.011253916,0.06072654,-0.059416417,-0.008021549,-0.048073903,0.0068513453,-0.0038743098,-0.028544404,-0.012964682,0.032229684,-0.00589353,-0.048818108,-0.017862756,-0.018153025,-0.045191575,-0.035075396,0.030264037,-0.0126670515,0.028639449,0.066902906,-0.040945962,-0.011018382,-0.025360798,0.04320837,-0.030613685,-0.02218026,0.05713647,0.14359418,-0.011759733,-0.09932621,-0.053710982,0.023656966,-0.00020415637,0.067502424,-0.02310155,-0.00832304,-0.029191922,-0.10335747,1.2570804e-33,-0.031630486,0.026252575,-0.0006182106,-0.056884915,0.07037732,-0.0134632485,-0.04746976,-0.008622511,-0.02213726,-0.048824728,-0.091774486,-0.06167053,-0.051043473,0.041520316,-0.003894097,0.01978163,0.021985713,0.05989485,-0.055608615,0.0024067294,-0.0001324441,0.02786378,-0.016752334,0.0126794,0.00014385056,0.04788087,0.032190748,0.017877102,0.11024584,-0.032657355,-0.020872986,-0.06886545,-0.00703884,0.012141374,0.050616328,0.014565096,-0.080725566,-0.045254517,0.038316403,0.00085308816,-0.01270338,0.01875392,0.0018975848,-0.020006264,0.005791875,-0.032440536,-0.069991596,0.06520384,0.08547997,0.049989797,0.05351102,-0.00955729,0.11376349,-0.009566554,-0.05732527,0.014750755,-0.049806982,0.08206222,0.03823423,0.042619545,0.01557833,0.053391848,0.015661867,0.058237433,0.029538764,-0.016825343,-0.07984565,-0.013674685,5.9484515e-05,0.04914747,-0.0447442,-0.012464166,-0.015698481,0.05797553,0.031284098,-0.052044924,-0.050706286,-0.02715033,0.02412795,-0.00028776436,-0.06603898,-0.009600081,0.019137314,-0.027001752,-0.07106107,-0.010864685,-0.04981357,-0.022115415,0.0019445292,0.07281656,-0.065088384,-0.046588633,-0.08647359,0.07629036,0.050036296,-4.1447192e-33,0.080296926,-0.0694782,0.07455233,0.010163593,-0.00878193,0.12581347,-0.022233868,-0.032513667,-0.022128763,-0.029407388,0.07456795,-0.044994555,-0.008160754,-0.06738269,0.04582577,-0.015644567,0.004705742,0.048052754,-0.07280281,0.06297683,-0.02969876,0.07543247,-0.056276508,-0.0055982075,0.032094806,0.0052814074,-0.016741643,0.09943229,-0.04856109,0.09108777,0.07016095,-0.01279546,-0.059249632,-0.012318617,-0.009887355,0.09331918,0.009426801,-0.018283917,0.092638664,0.0048181573,0.09272846,-0.024505753,-0.0010190802,0.04347445,0.022535644,0.057729434,-0.07378339,0.035086345,0.014632786,-0.059222605,-0.0337204,0.06013725,-0.007301785,0.04815264,0.046829067,0.036202047,-0.03112361,0.024106855,-0.014210354,-0.0428724,-0.078126594,-0.048658196,0.01690931,0.050470915,0.05557787,0.032648116,-0.004566137,0.0022755333,0.11983958,-0.071710505,0.11185518,0.036345683,-0.047384262,0.07134728,-0.008347309,-0.019297969,-0.06669342,-0.07458134,0.022428956,0.0047763847,-0.03627569,-0.049997725,0.04280455,-0.038443577,-0.025017971,-0.073368385,0.05567005,0.011107286,-0.041580625,0.04305114,0.052424762,-0.012675479,-0.031260613,-0.013603103,0.059338138,-3.2152748e-08,0.041029733,-0.051611938,0.09220014,-0.04888133,-0.018643172,-0.06691862,-0.0012195595,-0.014248469,0.0024153062,-0.0027926594,-0.023648063,-0.018355815,-0.00088759087,-0.044994026,0.0052475366,-0.031769525,-0.06879498,0.07358072,-0.006515319,0.0076542185,-0.046424303,-0.028135741,-0.12455827,0.02637417,0.06272835,-0.07187232,0.023666,-0.0076064807,-0.028580008,-0.006121484,0.070410214,0.0047826036,-0.03681728,-0.020580793,-0.07167377,0.025853708,-0.065424494,-0.02137939,0.058103006,0.014685165,0.04091745,-0.0013374527,-0.08582369,-0.04078829,-0.08111445,0.027959518,0.0010642458,-0.023605194,-0.097340025,0.011416939,0.05117747,0.040032294,0.03219928,0.0013599842,-0.089946315,-0.012482271,0.025689801,-0.0050011566,-0.052454527,-0.04994735,-0.0030718776,0.015510813,0.2485598,-0.06426597 +3.1.3.102,"Requires Mg2+. The enzyme, found in many isoforms purified from both bacteria and plants, is a member of the haloacid dehalogenase superfamily. Most of the isoforms have a wide substrate specificity [2], but isoforms specific for FMN also exist [3].",384,1.0,-0.07379787,-0.08430462,-0.059802357,0.0051549743,0.057800636,-0.005686876,-0.055757843,0.021615364,-0.015528392,-0.020425977,0.08035488,-0.068025,-0.04318407,0.06365715,-0.040089745,-0.009713495,-0.06532524,0.014952343,-0.016051412,-0.02494736,0.0959151,0.070164904,-0.041432165,-0.038414154,-0.028280161,-0.010704639,0.034653828,-0.049743146,0.048778486,-0.045860108,0.021963315,0.009425453,0.106624834,-0.031903554,0.08029994,0.055945806,-0.020810852,-0.055683985,0.034338355,-0.040369056,0.008198914,0.019337725,0.07598305,-0.0748334,0.01640198,-0.03704151,0.049804125,-0.016638724,0.042788062,0.010768707,-0.036887284,-0.034505993,-0.04883552,0.05552941,0.032602943,0.006960677,-0.07710104,-0.010439601,-0.07093062,0.067652516,0.00027481205,0.040499065,-0.026238387,-0.0429774,0.08211743,0.033152323,-0.027058147,-0.098640785,0.043755982,-0.048394028,-0.0061721737,-0.085315004,-0.06695465,-0.020997984,-0.041888196,0.089258455,0.02676824,-0.04086952,-0.00011348725,-0.007920121,-0.0022174981,0.022010142,0.10051018,0.06378197,0.036798216,-0.042676374,0.015305423,0.048682842,0.0026062285,0.09977022,0.04330547,0.059181586,-0.0050104307,-0.039687753,-0.002466473,0.080495544,-0.0055318004,0.056426216,0.042773217,0.0019426405,-0.0063737617,0.0043061953,-0.05910168,-0.0033441267,-0.09128822,0.003541113,0.03530812,-0.005736073,0.04904344,-0.0074661425,0.026237361,0.072873294,-0.0062066657,-0.033716694,0.007393344,0.027949812,0.01916702,-0.11410091,-0.02866125,0.035834022,-0.028563146,0.008087584,0.022829166,0.109832585,0.019468801,0.08015874,-0.17647283,7.4894965e-34,-0.0104622785,0.07810406,0.04558249,-0.018271605,-0.064564474,-0.022653215,0.026909772,-0.0024598616,-0.055296674,-0.06855698,-0.15553494,-0.033240285,-0.03247223,-0.028267687,0.010745085,-0.041161094,0.00039480106,0.011307045,0.051504645,-0.0017640587,0.008796749,0.043432362,-0.0037598507,-0.07157907,0.065595135,0.09235338,0.0059045097,-0.06482496,0.08588778,5.410017e-05,0.030837188,-0.14166841,-0.011137631,0.05900472,0.07949171,0.008264137,-0.0376209,-0.010576088,-0.075823456,0.032041285,0.019115446,0.051926833,-0.053587906,-0.007425026,0.060915936,-0.023765458,-0.058329064,0.040001266,0.010118164,0.079997145,0.053191952,0.025860794,0.017447578,-0.054086536,-0.002483679,0.019995414,-0.014795845,0.022509256,0.06151665,0.021300228,-0.00615588,0.034846634,-0.027356254,0.0700213,0.08469398,0.04757311,-0.09091261,-0.048487816,0.01980962,0.08459196,-0.034027398,-0.10474412,0.028213127,0.04561856,0.037500232,-0.064626575,-0.0540329,0.030743288,0.02770206,0.015199544,-0.009799037,0.0052096285,-0.037533544,-0.061776295,-0.09472435,-0.017984306,-0.014240626,-0.0065708426,-0.034744672,0.026964338,0.09623779,-0.009743294,-0.022886427,0.042972527,0.012478433,-2.0610578e-33,-0.0088600805,-0.06496723,-0.013227614,-0.09040931,-0.108239055,0.09906426,-0.024478031,-0.101775125,0.06219965,0.049149908,0.049222298,-0.008647862,-0.013301389,-0.08929374,-0.060045116,-0.047917657,0.008589799,0.090233214,0.0033330396,-0.011382042,-0.030665044,0.11683497,0.025826534,0.048880413,-0.001740709,0.03675448,0.038560905,0.11230078,0.064005256,0.05882533,-0.06437611,0.11774842,-0.029468523,-0.09410022,-0.035826404,0.009677794,-0.034567337,-0.02283356,-0.013740216,0.0051553547,-0.012651479,0.05571823,0.045987733,0.10428939,-0.017126039,0.052535467,0.007262532,0.018436505,0.030031776,-0.030255526,0.0021559868,-0.07054028,-0.051723838,-0.03114603,0.019107273,0.013313248,-0.010002251,0.0588929,0.00032150903,-0.041997217,0.011806497,-0.05402784,0.040163837,-0.06047216,0.025582764,0.0607773,0.045673896,0.07653363,-0.008308883,0.011793692,0.03401916,-0.0009705848,0.06182065,0.024587646,-0.045352355,0.076791026,-0.036815554,0.01649471,0.02278832,-0.050713025,-0.017731173,0.04499846,-0.050957873,-0.043805193,0.025672017,-0.11272636,0.01667523,0.060455296,0.004409447,0.0086945435,-0.043915138,-0.021252017,-0.06108198,-0.004875871,0.017572768,-3.627429e-08,-0.008367263,-0.07853077,0.023425326,-0.08851738,0.009714006,0.07462429,0.012007093,-0.012678319,0.06192092,-0.010903971,0.01833628,0.014478011,-0.020699631,-0.00973909,0.022349032,-0.027897265,-0.0059128664,0.05018897,-0.047407735,-0.0036312637,-0.07582805,0.008596112,-0.10545303,-0.009122289,-0.0073691867,-0.07344721,0.026279464,0.06999019,0.021378051,0.015044852,0.025317756,0.0361451,0.0075629647,-0.027776958,-0.13777122,-0.025908248,-0.005264823,-0.009650763,-0.08452532,-0.0013342138,-0.020917209,-0.01115347,-0.005805846,-0.023290243,-0.044266064,0.04076501,0.025307495,0.048730724,-0.019369768,0.057092886,0.012466867,-0.06400058,-0.0439776,-0.066676594,-0.10931385,-0.0050487723,0.06778691,-0.061172493,-0.03449143,-0.08902652,-0.0041195503,0.0019672315,0.14370057,0.016833717 +3.3.2.15,Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis.,384,1.0,-0.09099822,0.028394254,-0.13794957,0.0033918202,0.03207947,0.08167356,-0.09060253,0.08919227,0.016343145,0.04754525,0.049501415,-0.028311238,0.010443125,0.027309889,-0.038918212,-0.007599474,-0.067280024,-0.0015341198,0.0034656418,0.08454504,0.08654624,0.11346631,-0.021182442,5.8929538e-05,0.00860628,0.07181778,0.10453521,0.027905123,0.059327327,0.0039028877,-0.021409445,-0.06631433,0.08792382,-0.044673726,0.055436533,0.035719108,-0.017564515,0.0051054237,0.16976197,0.03620906,0.017292583,0.030076984,-0.040017974,-0.08902806,0.006555692,0.010949943,-0.011681599,0.08984065,0.036489576,-0.018515805,-0.0664876,0.016124649,0.004649256,0.06237615,-0.018251443,-0.006600955,0.010067345,-0.04969331,-0.026507992,0.035548102,0.018695662,-0.024253204,-0.0356139,-0.009281719,-0.0710465,-0.012703614,0.0041861045,0.032395355,0.12724552,-0.055464048,-0.04578733,-0.02866505,0.09931416,0.06603972,0.028232846,0.010149098,0.09733436,0.02383579,-0.069297925,-0.024679203,0.022210754,-0.098334104,-0.011745263,0.015760442,0.06122937,-0.06900354,-0.013359699,0.054270387,0.13401064,0.01897632,-0.02535988,0.012576776,0.0053562773,-0.073756665,-0.057683744,0.032251943,0.0045355577,0.025301797,0.022448035,-0.030971255,0.023683205,0.033592563,0.017502185,-0.08000821,-0.034653407,-0.034105927,0.05341277,0.024976056,-0.0017783368,-0.009922674,0.004361385,-0.017659292,-0.03218562,-0.07360419,-0.021252416,0.011759971,0.041791946,-0.07986098,-0.10117493,-0.011808083,-0.0115892505,-0.031752795,0.068118095,0.00017574879,0.011909611,-0.017383255,-0.09797522,-9.828284e-34,0.018037256,0.049543303,-0.017216617,-0.034799322,-0.011254623,0.04462499,-0.034848865,-0.0032082514,-0.0014996205,-0.13044886,-0.009981746,-0.09692653,-0.011169221,-0.004553236,-0.022309922,-0.00047859762,0.017706027,-0.056586836,0.100962184,-0.023290858,0.005263412,0.045132056,-0.030668821,0.015594452,0.05732882,0.034532875,0.0454716,-0.0017732518,-0.024999335,-0.00783177,0.07425978,-0.040923104,-0.059884522,-0.039327204,0.07543432,0.0033288395,-0.122811764,-0.009910477,0.0062685884,0.007539104,0.019210653,0.02426594,0.0138369175,0.053290084,0.03576856,0.040396385,-0.05452093,0.06416202,0.075170785,0.009791108,0.00041946876,0.0016040043,0.0387992,0.068018906,-0.11000617,-0.007822288,-0.033847593,-0.07603677,0.040691014,0.023419201,0.0481635,0.088471286,-0.031222476,0.079083726,-0.024307625,-0.024889901,-0.06363957,-0.0017733339,0.0025485563,0.054808483,-0.022441445,-0.08819406,0.030377718,-0.015679983,-0.0015075521,-0.013544046,-0.005223414,-0.045360744,-0.032622457,0.0016459124,0.03304995,0.004532351,0.0076120063,0.052599553,-0.08703632,0.0064269532,0.0008740517,0.0061066947,-1.5787913e-05,-0.045458697,0.08215806,-0.092620045,-0.060683068,0.017083026,-0.043267716,-7.1176018e-34,0.06751978,-0.008148035,0.045808412,-0.027073964,0.0049738195,0.06823458,-0.034273952,0.026713714,-0.05127845,0.012582321,0.017561747,-0.017121037,0.021429593,-0.047343213,0.04124856,0.07301942,0.11295449,0.0015285842,0.032834686,0.002121615,0.010850492,-0.00092460803,0.0045114458,-0.051124264,0.030864606,0.05821128,0.009100405,0.083597325,-0.010301115,0.053259917,0.029397909,0.047735382,-0.049986035,-0.09000392,-0.011245027,0.061014898,-0.030664694,-0.041595157,0.01491788,-0.045485746,0.05339378,0.007591911,-0.030602302,0.027265592,0.022175035,0.016187496,0.046633683,-0.016901458,-0.0793627,-0.031705394,0.030139878,0.07087095,-0.0043594,-0.039125834,0.028590335,-0.0866217,-0.050566703,0.030936683,0.048230704,-0.05626371,0.04089631,-0.07386034,-0.061066177,-0.036520544,0.00051694585,0.00044631062,0.06529805,0.077312514,0.00043402228,-0.0160043,0.016212396,0.051293526,0.046392925,0.02638164,-0.09600906,0.0969987,-0.0669115,-0.087549634,-0.03381166,0.057364278,0.032419696,-0.08355452,0.083163664,-0.047390558,-0.06958145,-0.026490474,0.03592067,0.013097416,-0.031925283,0.019633533,0.015622382,-0.04902249,0.03902376,0.056402832,0.027762095,-2.0981735e-08,0.07390174,-0.09148228,0.03204402,0.002148645,-0.03854316,-0.023011139,-0.07892131,-0.022886487,-0.008186358,-0.008478488,-0.04531908,-0.06839408,-0.008192254,0.04661055,0.050378148,0.011671867,-0.10817307,0.04469137,-0.03181395,0.0016325607,-0.07382791,0.0053625386,-0.1325425,0.004309293,0.020598957,0.010076577,0.0013442773,-0.111920655,0.0014896098,-0.052109726,0.03967972,0.0045705168,0.0071046655,-0.02582878,-0.1044523,-0.04487836,0.015557711,-0.039649535,-0.088209555,-0.0346545,0.042196956,-0.009624084,-0.050303586,0.09606509,-0.022970766,0.04180142,0.035359927,-0.020421553,0.00038871114,-0.14026494,0.035835292,0.019117996,0.052038815,-0.03724398,-0.11912091,-0.02002935,-0.047276866,-0.037602358,-0.039396606,-0.020820187,-0.069809906,0.020072294,0.090887904,0.097824395 +3.5.1.120,"The enzyme, characterized from the bacterium Comamonas testosteroni CNB-1, converts 2-aminomuconate to 2-hydroxyhexa-2,4-dienedioate, unlike the enzymes from Pseudomonas, which produce (3E)-2-oxohex-3-enedioate (see EC 3.5.99.5, 2-aminomuconate deaminase). The enzyme also acts on 2-amino-5-chloromuconate.",384,1.0,-0.031156454,-0.07909752,-0.058927324,-0.038876623,0.011242015,0.011119446,-0.04840661,0.050909482,0.0057518305,0.0013534328,-0.003451267,-0.15804397,-0.026104739,0.03106857,-0.0222861,0.053796165,-0.035729505,-0.014429108,0.002619593,0.020216215,0.10773796,0.055269275,-0.022233313,0.04581122,0.02614724,0.005580347,0.038291335,-0.0033120716,-0.02925702,-0.072433345,-0.013354601,-0.05818392,0.009998591,-0.07960931,0.110891804,0.015168323,0.01058504,-0.08307404,0.102221705,0.032081507,0.08301313,0.054388046,0.0069902395,-0.04520429,-0.006330292,-0.009554008,0.035217557,0.031656288,0.08344642,-0.055966787,-0.05801288,-0.06797735,-0.054370683,0.07224027,0.009524296,0.08808406,0.021813696,0.020639068,-0.06915749,0.01267775,-0.020575317,0.035208426,0.05812512,0.028482936,0.03783534,-0.041244633,-0.008800798,-0.11581518,-0.036544234,-0.075348444,-0.092812695,-0.09820508,0.045164697,0.07609526,0.022769775,-0.043596603,-0.0065013603,-0.015397919,-0.005155669,-0.04570209,-0.016538808,-0.06545549,0.04697407,0.0862375,0.019935152,-0.029074475,0.013091723,0.0009910084,0.08178014,0.014617355,-0.020265082,0.028580414,-0.04178145,-0.02925367,-0.02971426,0.024020646,-0.0044470136,0.12380757,0.07822276,-0.0039271736,0.03557741,0.073351726,-0.02513728,-0.114915915,0.0011760775,0.04562108,0.043776594,0.08768982,0.060404863,0.0027077538,-0.030097365,-0.016047724,0.066695,-0.0015154718,-0.06632177,0.09884032,0.06538084,-0.02154884,-0.041562926,-0.0075981133,0.051517133,-0.07399679,0.07528582,0.041507967,-0.034466557,0.043018654,-0.072745785,7.5212064e-34,0.04575725,-0.033284158,0.010614409,0.018718848,-0.025826413,0.019024374,-0.087200515,-0.009626797,-0.039735068,-0.052202445,-0.016886782,-0.042135213,0.026724497,0.08139581,0.012999795,-0.040561136,-0.051660113,-0.010043736,0.044154253,0.013870902,0.01832807,0.08014391,-0.07853057,0.04130549,0.018166887,-0.0028221298,0.04365869,0.030534502,0.018591547,-0.01907841,-0.035411783,-0.042603448,-0.119742855,-0.045763012,0.008493438,-0.017748846,0.00040456266,0.017879762,0.0020917037,0.09089503,0.01493233,0.03922342,-0.023254618,-0.04195069,0.08683245,-0.04716021,-0.019043166,0.071199484,0.09812718,0.0053710956,0.014300997,-0.090949304,0.08036663,0.025712866,-0.022062434,-0.01188007,0.04074742,0.06773323,0.10292062,0.045621537,-0.0039658113,0.05726838,-0.021763407,0.046050236,-0.012752141,-0.004695936,0.006409389,-0.043416206,0.025326628,0.05247285,-0.10392682,-0.0049656695,0.013418352,0.016601892,0.025246909,-0.1426471,-0.091783926,-0.025682932,0.054018516,-0.047796242,0.07868195,-0.040941175,0.022965455,0.012230382,-0.04774246,0.005590819,0.00881414,-0.013334248,-0.06312294,0.02963462,0.10148562,-0.040623594,-0.06007975,-0.0029088138,0.03266465,-1.3384787e-33,0.020767137,-0.020690482,-0.019124992,-0.027619952,-0.071225554,0.0050441884,-0.013869957,0.026910363,0.020853164,-0.021589734,0.12789187,0.003633582,0.03893754,-0.03462614,-0.008057912,-0.03495659,-0.01176118,-0.044554036,-0.04625521,-0.04516842,0.10260087,0.032119423,-0.04274626,-0.01721496,0.032657754,0.07261038,-0.07316215,0.13821425,0.08606576,0.050414883,-0.058380123,0.019452251,-0.0041777096,-0.012001709,-0.042623725,0.051217597,-0.029284708,0.008973701,-0.0064842217,0.024152892,-0.06643092,0.024460033,0.025280526,0.06301723,-0.036225114,0.08282029,-0.05077263,-0.05871056,0.027540965,-0.022710271,-0.022459403,0.005892846,-0.040923707,0.03007391,-0.027461262,-0.049704835,-0.040003594,-0.015798524,-0.0073185056,-0.028717408,-0.032450352,-0.0072405976,0.064479545,-0.033367213,0.02195293,0.040826384,-0.048299775,0.05941468,0.030268881,0.07108467,0.06568319,0.01229379,0.009744143,0.021507686,-0.024658082,-0.032899655,-0.07816352,0.0028930623,-0.025183234,-0.032316733,0.0029066105,-0.018232029,0.012722264,-0.069814585,-0.017624639,-0.08163514,0.027377352,0.09007623,-0.045272604,0.043868616,-0.0062744753,-0.013270197,0.007517208,0.04528564,-0.012805304,-4.2923727e-08,-0.02025934,-0.10327375,0.05385719,0.01841934,-0.0349024,0.024778994,-0.008755923,-0.002852375,0.075955294,-0.07065927,-0.03647359,0.064601116,0.00876242,0.023320543,0.05369603,0.04114622,-0.058157075,0.035718847,-0.0017442245,-0.01342561,-0.058854338,-0.03519434,-0.12469296,-0.010792641,0.0029893338,0.017109275,-0.015102423,0.040792458,-0.015390651,0.01774155,-0.06853602,0.019342871,0.06292602,-0.026909696,-0.070431545,0.024899257,-0.09083988,-0.01859932,-0.057538163,-0.030389275,0.054766167,-0.03453353,-0.103241175,0.009845344,0.08387523,-0.040836606,0.027672425,-0.0013509315,0.01670977,-0.110202014,0.08629235,-0.07605894,0.018357115,-0.023302928,-0.10922358,0.05836035,-0.05570116,-0.009136561,-0.03574718,0.005778871,-0.020250212,0.0164125,0.1934955,0.017943999 +3.5.4.42,"Requires Zn2+. This bacterial enzyme is involved in degradation of the herbicide atrazine. It can hydrolyse other N-substituted amino dihydroxy-s-triazine molecules, and prefers substrates with linear N-alkyl groups to those with branched alkyl groups. ",384,0.99999994,-0.07392964,-0.016063038,-0.081514984,-0.018577151,0.1262697,0.053940337,0.0076251635,0.0697822,0.05232348,-0.029664839,0.0046218596,0.080173194,-0.014536799,0.07568811,-0.07872383,0.05704956,-0.024034549,0.015686078,-0.035111073,-0.035241917,0.033652283,0.09994887,-0.0039670914,-0.0007611479,-0.019917123,-0.02506427,-0.0074888356,0.029881073,0.05270213,-0.010387049,0.10516586,0.06755364,0.0068616895,-0.05390051,0.0076973126,0.045715697,-0.0037976422,-0.022946613,0.061616987,0.012956553,0.064274244,0.06369042,-0.037442226,-0.017693937,0.011256087,-0.019501537,0.071667776,-0.012693051,0.009474746,0.0009331937,-0.018919513,-0.025387876,0.02514897,-0.00712546,-0.030127747,-0.0151955765,-0.07786272,0.012254053,-0.09472836,0.019868916,0.011971522,0.0037695859,-0.0124708405,0.003954283,0.018769044,-0.028615043,0.013536041,-0.02764816,0.02584028,0.0030896706,-0.044598643,-0.08431005,-0.023571154,0.020299088,-0.047772497,-0.05202959,0.033892013,-0.07273554,0.001853838,-0.111897476,-0.007107382,-0.06402819,0.041442133,0.046996664,0.083550595,-0.013333546,-0.07439946,0.052497357,0.08403266,0.042994857,0.047110587,0.07145623,0.063538514,-0.06401778,-0.020965584,0.060006108,0.022400467,-0.062987596,-0.016687628,0.06162585,0.04342025,0.031456232,-0.014067708,-0.062259723,-0.03351691,0.043285612,0.061762445,0.038988654,-0.02597188,0.011088015,-0.02998283,-0.01581098,0.03287775,-0.03562814,-0.056802623,-0.008000418,0.030234383,-0.06393516,-0.061783914,-0.0590923,-0.011734232,-0.01856449,-0.04547048,0.061889574,-0.002492545,0.08202077,-0.09459916,3.1354416e-33,0.00020172927,0.0349953,-0.10493437,-0.008683661,-0.051057708,0.030741766,-0.012857399,0.0044479496,-0.0016699355,-0.04666046,-0.04568059,-0.19254477,-0.022999108,-0.029861258,-0.018293701,-0.026176997,0.015076791,-0.01342939,0.06106655,0.018436624,-0.010644668,-0.0022173887,-0.108529456,-0.013110793,0.04548036,0.05604332,0.0047447477,-0.019478679,0.009405008,-0.03217406,0.037029475,-0.033206325,-0.12391138,0.02250611,0.1009014,-0.0032915312,-0.0856511,0.04025648,0.06888513,0.027678726,-0.0011317121,0.038566146,-0.022632608,0.04565633,0.0813579,-0.0035983415,-0.049626563,0.12867203,0.007812759,-0.01597981,0.031374317,-0.020814108,0.014696208,0.037854716,-0.07310133,0.078545764,-0.016156688,-0.0071712607,0.054798782,0.009765817,0.0034281204,-0.009223573,-0.12136105,0.041912902,0.050112244,-0.033311874,-0.010286297,0.009355155,0.04561367,0.079329096,-0.084103845,-0.00199093,0.040710498,0.09623616,0.031806823,-0.091201656,-0.045751162,-0.015739255,0.13799714,0.0076615703,-0.019592788,-0.024497045,0.01263925,0.014217979,-0.071416415,-0.009418003,0.015234975,-0.02412076,-0.012345731,-0.0026389675,0.11414454,-0.123838335,-0.02945057,-0.005054109,0.02200313,-3.6557665e-33,-0.017225226,0.0120825125,0.000107784435,0.0008804396,-0.05327944,0.028134337,0.013816698,-0.10152398,-0.009536881,-0.050162364,0.06948198,0.019522179,-0.002004277,-0.03262266,0.03490849,0.036549717,-0.05161393,0.03775484,0.017929576,-0.06296413,0.0081448,0.050690528,0.022834193,0.030347176,-0.071513526,0.014478787,-0.013633663,0.070841625,0.11178182,0.1284218,-0.0027487534,-0.0152446,-0.05934951,-0.12170743,0.012735426,0.039806478,-0.04988679,0.04014606,-0.13712724,-0.07095991,0.080908164,-0.029790876,-0.0016236922,0.06144516,-0.019505119,0.07093936,-0.07674081,-0.030970125,-0.040321175,-0.055020083,0.051470168,0.010157434,0.00017695471,-0.0029265601,0.050451137,-0.01273071,0.07589279,-0.042474106,-0.012125554,-0.037581034,-0.01787429,-0.008220997,0.0023936506,0.02050454,0.009265387,-0.017670348,-0.010642218,0.10814621,0.0043356214,0.01302683,-0.010517935,0.07211043,0.05261396,-0.013737206,-0.10907073,0.02391966,-0.08320777,-0.03637935,0.03750195,-0.061351478,0.0354451,0.018409692,-0.03320751,-0.03762154,-0.0009639475,-0.045229163,-0.0046037724,0.09467689,0.050468944,-0.021925258,0.0028360786,-0.049162153,-0.02916303,0.030837873,-0.035494417,-3.8046434e-08,-0.04956627,-0.045062277,0.04864483,-0.10128644,0.010344941,0.0018734977,0.013376453,0.053772755,0.031430442,-0.06706445,-0.027410524,0.06871236,-0.0052932072,0.026389755,0.045358643,0.058869023,-0.045961753,0.023938036,-0.028888812,-0.025748,-0.07273141,0.03639096,-0.18220499,-0.02723332,0.029949483,-0.0049864175,-0.030179113,0.09578599,0.116551675,-0.03865433,0.06367236,-0.011894612,0.017808039,0.025042752,-0.072732374,0.022664871,-0.018329931,-0.120539114,0.024468502,-0.025546316,-0.038290005,0.049889613,-0.034603443,0.015221838,0.03999071,-0.06832363,0.04233485,0.011422946,-0.0009211417,0.025245111,0.037297223,-0.018134037,0.006637604,-0.04484401,-0.027802885,-0.04029795,0.032885794,-0.026827272,0.0076434757,-0.025297178,-0.022665462,-0.004926957,0.12923454,0.005232759 +4.2.1.164,"A pyridoxal 5'-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine. Requires ferredoxin/ferredoxin reductase or flavodoxin/flavodoxin reductase [1].",384,1.0,-0.077095665,-0.06376184,-0.16301109,-0.03751028,0.06529536,0.03868909,-0.006767079,-0.017414114,0.015939634,0.041591436,-0.02459296,-0.030844536,-0.04863168,0.035916533,-0.07615115,0.04656147,-0.06855018,-0.003809548,0.053169906,-0.029793805,0.08727496,-0.0063920794,0.03620136,0.012831711,-0.020494385,0.04806956,0.05660085,-0.022360347,-0.075185955,-0.09270536,-0.051970106,0.009871867,0.054905437,-0.12009541,0.030376125,0.13983114,-0.026114454,-0.02580501,0.011569034,-0.030522015,0.061765525,-0.0008627863,0.03326738,-0.015848825,-0.047694337,0.008254687,0.056280386,0.058515687,0.07435814,-0.03856644,-0.04753396,-0.017379016,-0.054087143,0.030432623,0.013896874,0.0050484473,0.02698922,0.00065060065,-0.036024433,-0.017128216,0.026930276,-0.012577628,0.0074483426,-0.0042256108,0.008118518,-0.058700196,-0.009308201,-0.04553523,-0.06139401,-0.0426323,-0.026691763,-0.04546813,0.09988014,0.063702114,-0.056450974,0.06135989,0.031222528,0.023150094,0.010983465,0.031551126,0.027751593,-0.003775909,0.010300245,0.119244345,0.051485773,-0.032015633,-0.011069583,0.010430453,0.049115743,0.033609264,-0.014013045,0.029478455,0.0035925582,-0.027533967,-0.052129116,-0.008586803,0.015418667,-0.0050426545,0.009132184,-0.04480297,-0.0012238483,-0.03849792,0.036387317,-0.11553858,-0.07420093,0.00093591574,-0.04970582,0.054929107,0.077713296,0.029879436,-0.007546552,0.059105255,0.028037587,0.006920484,-0.017908504,0.034181453,0.008809331,-0.10261428,-0.08747,0.05261,0.00695724,0.014251587,0.026481256,0.11278245,-0.05221195,-0.05721235,-0.16826609,5.5058308e-33,0.08611243,0.042427808,0.029372858,0.008600856,0.021543989,0.02413757,-0.003559569,-0.044369362,-0.035002496,-0.061960608,-0.0649802,-0.05935677,0.08181894,-0.045152657,-0.045773074,-0.042026315,-0.0127588,-0.007459399,0.061615936,-0.031447172,0.0078123827,0.09671553,-0.10488584,0.034337968,0.058776967,0.09137037,-0.064035855,-0.06376265,-0.0099667115,0.0029419656,0.06708309,-0.094981104,-0.119495675,0.012376408,0.070214055,-0.08086954,-0.03495159,-0.052875597,-0.06548787,0.031790018,0.0102708405,-0.0070431367,-0.009606925,0.010051233,0.036896802,-0.0613214,-0.020675583,0.059165925,0.051221795,0.12768368,0.025187591,-0.07792592,0.08694493,-0.015192564,-0.15069322,0.039119475,-0.038265258,-0.02346411,0.02835945,0.06646915,0.047430743,0.016223928,-0.053057857,-0.02471444,-0.035219453,-0.03395723,0.03293229,-0.07361469,0.013745043,0.065959334,-0.058057796,-0.018810628,0.039447974,0.021797657,0.0036874127,-0.0023791478,-0.04910313,-0.0011088216,-0.014557867,0.032058075,0.010804175,-0.07955797,-0.037394453,-0.035395853,-0.05932457,0.034564823,0.011021922,-0.04781166,-0.032079477,0.026446415,0.069144316,-0.12655678,-0.03818717,-0.02165299,-0.030944524,-6.507785e-33,0.091288805,-0.11841858,0.102066144,-0.062376723,-0.012183719,0.027000582,0.07484251,-0.026278215,-0.031354208,-0.02030805,0.038069386,-0.069769725,0.028980209,0.014972092,0.0020464805,0.07292707,-0.0036354233,0.046258505,0.06826384,0.01896604,-0.01078006,0.066914186,-0.00627694,0.0049654124,-0.0015608371,0.026539382,-0.0060876636,0.043388397,0.027520716,0.056338098,-0.06794137,0.031973545,-0.06591312,-0.06990701,-0.054299664,-0.006675259,-0.092974044,-0.045909226,0.025450341,0.01360682,0.04990135,0.06848502,0.009055448,0.024381077,-0.014981999,0.0021020193,-0.056299478,0.046403818,0.011744107,0.009348204,0.03965747,0.01856831,0.014364072,-0.012501378,0.00092292525,-0.03180593,-0.012808714,0.047914095,-0.01816625,0.012018863,-0.020656426,-0.094267465,0.023170551,0.105050825,0.053931512,0.12741606,0.0047964486,0.015271556,0.0028824452,0.046082318,0.046791606,-0.021872591,0.053975817,0.1016664,-0.027640624,-0.009744482,-0.059088886,0.036366604,0.021004315,0.019183172,0.02108722,0.013058839,0.022218566,-0.0566402,0.01859344,-0.02550729,0.08002207,0.048100952,0.028532155,0.024894457,-9.4613446e-05,0.011236499,0.004921052,0.06126804,0.08651132,-4.17998e-08,0.0036582197,-0.051346,0.029952165,-0.015757708,0.032790355,0.030250555,0.05155348,-0.06791935,0.06873976,-0.015097197,0.01888231,0.051172912,0.03741301,-0.013923437,0.08522078,0.042282924,-0.045843367,-0.0032131062,-0.0042966055,0.0044607483,-0.037743326,0.008898939,-0.1611938,0.06219966,0.05689491,0.0029681288,-0.028534617,0.0049418635,0.025884114,-0.04342178,-0.0004012224,0.037197657,-0.025725728,-0.061886266,-0.088638514,0.018645754,-0.06324446,-0.043460097,-0.029377738,0.03793631,-0.04543606,0.02022072,0.019837126,-0.02879919,-0.023519462,0.044386413,-0.020276438,0.0036847445,-0.0038720386,-0.04171976,0.01758048,0.0161817,-0.059071872,-0.0781946,-0.11811642,0.028553769,0.013129333,-0.020421932,-0.032926295,-0.011474909,-0.030931521,0.028819997,0.14351319,-0.06761644 +4.2.1.165,"The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 1.1.1.396, bacteriochlorophyllide-a dehydrogenase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme catalyses the hydration of a vinyl group on ring A, converting it to a hydroxyethyl group.",384,1.0,-0.062374096,0.0135037005,-0.06464541,-0.06665347,0.05466197,0.03799862,-0.042134162,0.01680079,0.0527374,-0.072514325,0.026127603,-0.07194692,-0.019257318,0.0033861124,-0.025214667,0.03817261,-0.15819223,0.03999201,-0.07210214,-0.052961297,0.00065875996,0.014065255,-0.07074811,0.004323609,0.020093624,0.02981368,0.020816006,0.0064545413,-0.065302625,-0.08799326,-0.0030633255,-0.018604616,0.051051214,-0.03183749,0.05075085,0.11105741,-0.03084894,-0.09255282,0.0321771,0.06419282,0.0012425518,0.012210464,-0.04935318,-0.062142406,-0.04966326,0.012186737,-0.013644628,0.07600564,-0.0022413472,-0.025474621,0.0072803,-0.007698247,-0.03208718,0.03440159,-0.025583286,0.020762308,-0.024440082,-0.041062556,-0.04956645,-0.021176273,0.02553166,0.0017442832,-0.026360145,0.036901172,0.0102227405,-0.0891319,0.081826314,-0.06920974,0.022918908,-0.0043976726,-0.08456466,-0.06680875,-0.011918613,0.04540995,0.017357014,-0.046957683,0.018611316,-0.0057926686,0.021967849,-0.038220633,0.04225298,-0.012835825,-0.05109252,0.041753918,0.05403937,-0.0042528682,-0.018216431,-0.018899675,0.036326554,0.017284025,-0.015512369,-0.018507158,0.013234213,-0.04788869,-0.074554175,0.124339625,-0.019680647,-0.04980584,0.07107248,-0.034017388,-0.046633825,0.04139617,-0.019797005,-0.09246748,0.036857795,-0.0246265,-0.016184835,0.11639531,0.008386449,-0.009419069,0.028652845,-0.053401623,0.07165461,0.0043355324,-0.0298832,0.11216296,0.053644348,-0.03868428,-0.06882738,-0.042385533,0.031955414,-0.043876972,0.028860316,0.035886854,-0.057561804,0.045327503,-0.14260143,2.4167286e-33,0.06382786,-0.05694459,-0.0010782254,-0.023654917,0.011465021,-0.00877978,-0.08417438,0.059851244,-0.064787395,-0.062336963,-0.04499481,-0.053887796,0.07356449,-0.03088825,-0.046885043,-0.034320835,0.009505749,0.037449475,-0.038806986,0.0042031114,0.009275895,0.08335245,-0.05139582,0.09110846,0.0062352507,0.06649554,0.017446466,-0.0055348845,0.1130476,-0.009077826,-0.014936395,-0.07103191,-0.060953442,0.058451343,0.03886292,0.03578495,-0.042974107,-0.017651353,0.05865171,0.0958435,-0.03703059,0.025774622,-0.018020744,-0.037784133,0.06980704,-0.012145383,-0.046679422,0.082705304,0.08550326,0.07032999,-0.0064605544,0.026753346,0.08959668,-0.068826675,-0.06238668,0.029286454,-0.019228242,0.06274886,-0.031708315,0.096670896,-0.02454693,0.08803209,-0.05392439,0.01584432,-0.01085749,-0.013282606,-0.036582276,-0.029596336,0.039145473,0.015363557,-0.11401119,0.014105103,0.06226718,0.05410403,0.09931701,0.003293927,-0.015163241,-0.022071183,0.036542416,-0.0019833727,-0.054146208,0.08051663,0.0798547,-0.061291236,-0.08326251,-0.026445165,-0.03170041,-0.07257136,-0.0016848916,-0.020892581,0.025822314,-0.06979206,-0.037082653,-0.0206559,0.046822622,-4.6166505e-33,0.10692718,-0.074696414,0.044097293,-0.0575983,0.02307862,0.038425844,-0.010529077,-0.06596666,-0.019626938,0.045536686,0.052257057,0.058835503,-0.05297223,-0.026727438,0.013444692,-0.027630957,0.09281936,0.072876394,-0.053340226,0.021794084,0.030336862,0.07430202,0.07957855,0.031986013,0.0093408935,-0.025665425,0.028890466,0.017976567,0.103193626,-0.0041125263,-0.024918582,-0.05265935,-0.032902647,0.024268176,-0.014701085,0.0632842,-0.05319291,-0.009801732,-0.021670504,0.007530049,0.010384659,-0.04539718,-0.024632012,0.02703871,0.05222181,0.051618703,-0.0576739,0.03763366,-0.014031341,-0.068634294,0.01667594,0.044581495,0.025768356,0.02061398,-0.0023854668,0.03924247,0.1104938,-0.013506417,-0.016501928,-0.00447369,-0.018657193,-0.03947951,0.08742002,0.0079668,-0.037017222,0.03580491,-0.014898851,0.050553195,0.032012627,-0.029165782,0.04708869,0.04108685,0.04555049,0.0046432316,-0.056165464,-0.07775311,-0.042747974,-0.13684027,-0.028723879,-0.053830512,-0.026061306,0.020654816,0.011379949,-0.027810453,-0.0032986382,-0.06548164,-0.013024534,0.037224688,-0.034934904,0.00934626,-0.0044511347,-0.014307204,-0.0023988602,0.08919249,0.06101375,-4.376284e-08,0.033239882,-0.010332228,-0.0022845443,-0.054320287,0.04862888,0.054674234,-0.037797652,0.013409595,0.07698187,-0.057488423,-0.0049845823,0.066397645,0.04725969,0.008125299,0.0074726515,0.031051923,-0.0028538897,-0.0493139,-0.018419188,-0.017869944,-0.06902731,-0.018350178,-0.13947491,0.060895048,0.0002542303,-0.030633593,-0.00014303197,0.05445088,-0.0031844946,-0.047685504,0.014136415,0.023776125,-0.037245147,0.033971872,-0.0017389151,-0.043681595,-0.06897515,0.0030690895,-0.033042867,0.05230585,0.080750205,-0.042403117,-0.076986946,0.090274476,0.05509078,0.025105735,-0.033609632,-0.016564868,-0.011124992,0.043119118,0.073773004,-0.039180245,0.03175196,-0.028567428,-0.12010817,-0.024053726,-0.04318429,-0.10352529,-0.049577113,-0.0031087308,0.009461861,-0.0038519516,0.2166499,0.056298655 +4.2.1.166,"The enzyme, characterized from the bacterium Streptomyces viridochromogenes, is involved in bialaphos biosynthesis. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase. The similar enzyme EC 4.2.1.3, aconitate hydratase, cannot catalyse this reaction.",384,0.99999994,-0.009044724,0.0152155105,-0.16525646,-0.03816078,-0.00022781784,0.07020948,-0.066318676,0.06349607,0.08046279,0.014852787,0.022060292,-0.050089832,0.000429752,-0.008850072,-0.04407993,0.0020063783,-0.038896933,-0.01615363,0.0454711,-0.046592254,0.11670074,0.055075612,-0.018217418,0.00788354,0.019907845,0.013306669,0.08912026,-0.018751854,-0.032599196,-0.052667174,-0.043868847,-0.04778941,0.060498156,-0.10588391,0.0709539,0.08619295,-0.04090969,-0.080327265,0.12391838,0.027065555,-0.0046106223,0.030502014,0.018315902,-0.054100122,-0.024596957,0.036086105,0.01866169,0.0929025,0.035354044,-0.039593883,-0.046642624,-0.038833752,-0.06426673,0.02311906,-0.002353703,0.022677425,-0.105219506,-0.027472282,0.01585171,-0.025755532,0.019708611,0.010426765,0.03540054,-0.026523387,-0.020149026,-0.04810098,0.03206862,-0.0997117,0.030318765,-0.038139503,-0.054721247,-0.06690613,0.04836145,0.04870661,0.0038701969,0.03677156,0.032915723,0.03691334,-0.0116699,-0.01288924,0.01682481,-0.059682265,-0.058326602,0.074900866,-0.0005554192,0.03222966,0.006202491,-0.015462313,0.11849176,0.008056557,0.041876312,-0.038370565,0.05529858,-0.09432162,-0.0482589,0.019430874,-0.042084534,0.0012440053,0.01775431,-0.027152235,-0.014818203,0.02737942,-0.0036545142,-0.043232046,-0.02115805,0.021805806,0.011708902,0.10729511,0.051751968,-0.018373068,0.0001942676,-0.006246185,0.024028754,-0.023065224,-0.075499766,0.10064617,0.09469492,-0.096824504,-0.107227564,0.029213313,0.059720576,-0.039875526,0.07320263,0.047559496,-0.0338685,0.014620939,-0.10862583,4.2435464e-33,0.05173491,0.005976707,0.028838664,-0.07102675,0.090003744,0.01430793,-0.07254252,-0.025341745,-0.0074537527,-0.12090139,-0.11058004,-0.0328228,0.055880506,0.0014827751,-0.024316031,0.027324032,0.003706655,0.007390896,0.042752814,0.0018162321,0.03572211,-0.0011081758,0.0155288465,0.051154636,0.010986802,0.09814608,0.012927,-0.011846479,0.019285217,-0.008659734,0.0030760202,-0.025610391,-0.055551156,-0.016633088,0.018227428,-0.07284792,-0.08081286,-0.09097085,0.076499306,0.04027176,-0.020667918,0.008972282,0.004056334,-0.0079588145,0.07009744,-0.06482797,-0.03153978,0.084369995,0.034965012,0.120846614,0.021022527,-0.016269594,0.09002373,0.013010643,-0.100285344,0.02050443,-0.030991832,-0.040160235,0.06786182,0.078285575,-0.01002742,0.11185235,0.0006079242,-0.049154744,-0.02484218,-0.009751453,-0.05543498,-0.037458908,-0.01203481,0.04239894,-0.03335515,-0.08432871,-0.005185687,0.07725768,0.0070537007,-0.088531315,-0.04394463,-0.016592335,-0.000403058,-0.007430549,0.015805908,0.06903725,0.04995869,0.02232489,-0.027039707,-0.016335223,-0.012335151,-0.061323896,-0.012626954,0.039577253,-0.009885061,-0.026559047,-0.088928625,0.048761267,0.014840358,-4.454474e-33,0.12777294,-0.08131727,0.032686777,-0.067897014,-8.063851e-05,-0.0033236637,0.0026329204,-0.04276233,0.029193169,-0.00978027,0.030817458,-0.018107876,-0.033955116,-0.060678095,0.016356628,-0.023453318,0.05930204,0.060016245,-0.02971365,0.003782649,0.0019352791,0.053888723,0.014587535,-0.029664492,0.021931173,-0.050359104,0.015224106,0.07710291,0.008586125,0.055886805,-0.009941865,0.008206511,-0.03224062,-0.025286434,-0.013658814,0.02745238,-0.017779479,0.028687924,0.06732562,-0.017256094,0.09443011,0.025946077,0.0035841677,-0.019680863,0.041178808,0.060444787,-0.023781877,0.06207211,-0.09688353,-0.050238457,0.07374422,0.01820344,0.018237652,0.019425463,0.028938299,0.016717235,0.012162238,0.033127464,0.0018300752,0.0074221925,-0.015325945,-0.07030689,0.05315275,-0.0019723573,0.08395602,0.028980585,0.00090255245,0.07139558,0.076130316,0.011730583,0.057592284,-0.021348871,0.008961014,0.012737484,-0.039512727,0.004214371,-0.102555744,-0.063888945,0.045423217,-0.075353354,-0.03196007,-0.016319193,0.06800818,-0.029988194,-0.049820516,0.002092046,0.024443958,0.08886807,-0.0010656057,0.08665356,-0.042541854,-0.080641784,0.007910635,0.08028243,0.07136297,-4.162282e-08,0.026289346,-0.0062503745,0.022413008,0.008438972,0.00383317,0.007115725,-0.039067082,0.005610171,0.052192215,-0.030556146,-0.017224688,-0.0180778,0.021778302,-0.042940598,-0.016067551,0.09869651,-0.07063442,0.05374267,-0.03389248,0.04530918,-0.043046553,-0.0076521765,-0.13628158,0.031673495,0.036967315,-0.057673145,0.03421824,0.0044385297,-0.05656738,-0.011679878,-0.012438593,-0.0116341105,-0.009619962,-0.04896339,-0.09112404,-0.09268126,-0.05146755,-0.029394612,-0.014357603,-0.0028153148,0.052649558,0.020011762,-0.037662696,0.01860148,-0.020290965,0.044492304,0.025750484,-0.026511922,-0.03960395,0.0020792678,0.056544494,0.012950999,0.008876525,-0.056328066,-0.11864239,-0.05499368,-0.0013501551,-0.09756887,-0.038366552,-0.035680186,0.041589,0.025721477,0.22509767,-0.012124907 +4.2.1.167,"The enzymes from the bacteria Acidaminococcus fermentans and Clostridium symbiosum are involved in the fermentation of L-glutamate. The enzyme contains [4Fe-4S] clusters, FMNH2 and riboflavin. It must be activated by an activator protein. Once activated, it can catalyse many turnovers.",384,1.0,0.015315117,-0.07663942,-0.09405849,-0.009566002,0.06278805,0.0677704,-0.032477003,-0.0034228107,0.011860433,-0.03496429,0.05672601,-0.06683577,-0.01889957,0.061350897,-0.0023859374,-0.023699688,-0.06459745,-0.04356374,-0.009803731,-0.053178977,0.068888254,0.06543503,-0.008769143,-0.08828856,0.03039452,0.050419845,0.085106,-0.047359657,0.012783773,-0.05322678,0.007447608,-0.024443148,0.11990301,-0.030345796,0.04309797,0.04657615,-0.038499273,-0.0654364,0.16102546,0.0071607474,-0.018578304,0.030904885,0.040155724,-0.09388651,-0.06947087,0.016093096,0.022481734,-0.016386079,-0.004289039,-0.04010638,0.0032578325,-0.04530379,-0.00510612,0.05342244,0.025085835,-0.006464989,-0.031266715,-0.042947683,-0.019463593,0.050521806,0.016391208,0.032168638,-0.013223225,0.0032409607,0.007272382,-0.038738254,0.066542074,-0.042169295,0.016179282,-0.07479528,-0.01769367,-0.03775648,0.015300099,-0.041247327,0.028223893,0.041798487,0.07198092,-0.018958438,0.027826512,-0.06740438,0.03284516,-0.011474105,0.032250203,0.05067983,0.0025998722,-0.020652134,-0.014150654,-0.001023595,0.06140965,0.059639983,0.053857673,-0.020470709,-0.055000287,-0.10270399,-0.012720195,0.017893871,-0.012796562,-0.016729385,0.05160871,-0.02587033,-0.03359692,0.07987649,0.004887566,-0.07516279,-0.04690203,0.02149319,0.0035718807,0.09485573,0.02684268,-0.02942788,0.035715453,0.08142913,0.045349047,0.006037214,-0.01688584,-0.031674188,0.12517221,-0.082575545,-0.09733897,-0.0011084683,-0.0016465,-0.015827606,0.03703735,0.046224914,-0.044016115,0.030604294,-0.14774476,3.8964306e-33,0.068232566,-0.015030727,-0.02040437,-0.06991083,0.031559315,-0.018004438,-0.07278444,-0.0010522617,0.042841837,-0.009003804,-0.110596485,-0.059083737,0.05033464,-0.050529636,-0.02011457,0.0037878072,-0.04475279,-0.026074076,0.042801768,-0.0059322184,0.018297398,0.0572471,0.026749685,0.0058375793,0.009476356,0.13331984,0.051385075,-0.011156375,0.009170361,-0.0068385378,0.0052537145,-0.0912828,-0.102972426,0.003501056,0.07062777,0.024232555,-0.05713934,-0.045324557,0.0233097,0.003365961,0.02117775,0.056998435,-0.056342617,-0.0098044,0.0034483215,0.0017357925,-0.05560411,0.10756127,0.03460597,0.12961529,0.04136822,-0.051276382,0.053702477,-0.060859386,-0.05094758,0.03817274,-0.04283529,-0.013262148,0.06391966,0.04830445,0.013678811,0.029887455,-0.05124064,0.044904076,0.045827348,-0.011074861,-0.0046365745,-0.07667263,0.03861679,0.07091943,-0.07111633,-0.05689443,0.06863311,0.0036796487,-0.022225864,-0.0460915,-0.06494062,-0.075504705,0.021081053,0.021635983,0.011194816,-0.02107722,0.051107388,-0.034041278,-0.035769727,-0.027893556,-0.057373792,-0.05272114,-0.023193168,-0.022519253,-0.028839294,-0.041633375,-0.005586355,0.06882314,0.0057221428,-4.74817e-33,0.12978671,-0.09018273,0.08264262,-0.08304199,-0.058023557,0.021097474,-0.0021462424,-0.03040027,-0.054858133,0.03360404,0.035580166,0.0110720005,0.03721469,-0.04681808,0.02873918,0.023514012,0.025422644,0.08423606,0.0022432622,0.03610107,0.021465393,0.071120106,0.06374596,0.016109625,0.114868775,0.017843852,0.023093648,0.08022418,0.0112197455,0.042284977,0.031146891,0.005031721,0.003241739,-0.12217085,-0.028861063,0.0018027765,0.010678482,0.027603498,0.045296773,-0.020107165,0.037745267,0.10159479,0.009035792,0.051464096,-0.035875402,0.04432135,-0.034951176,-0.030316686,-0.025699848,-0.013762433,-0.0022714185,-0.0550709,-0.03656462,-0.06689199,0.016302723,0.025203548,0.01054653,-0.010821902,-0.045235533,-0.04169931,-0.086056694,-0.11194106,0.03738309,0.005535486,0.060324535,0.039110675,0.07653501,0.038716678,0.05858265,-0.021804795,0.05511837,0.0058274097,0.046010263,0.018732477,-0.06717332,-0.00064873847,-0.073778585,-0.07673291,0.040041175,-0.038253624,0.03815991,-0.0064497422,-0.030707482,-0.04345468,0.014366549,-0.10063799,0.016848696,0.15784703,0.05690991,0.020207372,-0.049701314,-0.006483988,0.04809625,0.027050553,0.043695655,-3.9608196e-08,-0.022385327,-0.047993463,0.038554158,0.024572294,0.024908517,0.057335854,-0.077881135,0.014620964,0.021795243,-0.02518556,0.032074917,0.084427245,-0.079921804,-0.009501194,-0.00032313567,0.0044424566,-0.09366353,0.058158103,-0.043912582,-0.0063667577,-0.072798036,-0.020882964,-0.08632679,0.061697293,0.04848453,-0.06548762,-0.009376916,0.02303879,0.020459767,-0.04023359,-0.018261768,0.045187477,0.035205644,-0.07178063,-0.12304802,-0.043482933,0.008023028,-0.029867241,-0.041119438,-0.008166486,0.01694507,0.022854479,-0.058074694,-0.0064143995,-0.11906922,0.031768195,-0.057076924,0.05184288,-0.029002337,0.026904853,0.062836155,-0.033968747,-0.026488816,0.020284109,-0.10921175,0.0027316976,-0.008318683,-0.05187127,0.031923432,-0.043305967,-0.010975968,0.05785848,0.14705986,-0.061439935 +4.2.3.154,"The enzyme, characterized from the cyanobacterium Nostoc punctiforme PCC 73102, is involved in the biosynthesis of the sunscreen compound shinorine. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.155, 2-epi-valiolone synthase.",384,1.0,-0.08803536,0.057393588,-0.10471352,0.031825818,0.081902556,0.041064017,0.009289267,0.029357502,-0.020116767,0.0020799304,-0.0014113726,-0.08509809,-0.024468448,0.0562994,0.0037912629,0.0068096323,-0.051801406,0.043057844,0.027943034,-0.012229117,0.03141764,0.0044354126,-0.0021178015,-0.009442454,0.04177941,0.07028738,0.005981345,-0.0056128507,-0.03655113,0.009907653,0.001764522,-0.011576214,0.01141757,-0.066166535,0.07613485,0.018979002,-0.019748233,-0.13074577,-0.051576123,0.065119356,0.07393633,0.033898216,-0.06587515,0.018428374,0.0387457,-0.03139697,0.018753812,-0.03245109,0.063971065,-0.084850885,-0.038070068,-0.05816117,-0.019372126,0.010757106,-0.0005520021,0.028997779,-0.08262298,-0.027114162,0.024380162,0.028079478,0.07404371,-0.034778245,-0.03777607,0.00622589,0.0719911,-0.07554765,0.017380977,-0.07691299,0.017431516,-0.05556021,-0.081636295,-0.009972245,-0.04414179,0.0029308633,-0.11035341,0.067994595,0.036016863,-0.011191557,-0.022494465,-0.04811151,0.034940213,-0.0022034775,0.053926814,0.057563644,0.09181964,0.01501363,0.06767951,0.043046556,0.052902102,0.15061668,0.036472917,0.06909014,-0.0041864277,-0.05839234,-0.069702715,0.05473722,0.015533206,0.059750713,0.018806808,0.0076156636,-0.014051498,0.026310338,-0.041564085,-0.04515856,-0.047798473,-0.03574913,-0.019916082,0.072715275,-0.038659886,0.05090066,-0.014126853,0.011490495,-0.044113766,-0.000761666,-0.01943894,0.083909556,0.055826597,-0.022522762,-0.09207597,0.028769713,0.038463302,-0.036880616,0.05965559,0.08859315,-0.012784868,0.014963599,-0.096084625,1.9878524e-33,0.09410234,0.13853882,-0.007841624,-0.0438169,-0.013947681,0.048038214,-0.085675456,0.033602312,-0.035151187,-0.09148397,-0.08668127,0.037231326,0.06526873,-0.035841607,0.007970257,-0.0020231782,-0.0005407176,0.029754182,0.047065184,-0.08103241,-0.029190822,0.03960678,-0.0027520778,0.0071435897,-0.065783665,0.07183347,-0.040038064,-0.029497195,0.041056648,0.0018679764,-0.0018204105,-0.15032339,0.032912444,0.021586772,0.14681351,-0.030492727,0.0045045675,-0.07775906,0.045753438,0.016436944,-0.045526743,-0.023124099,0.059621044,0.046947613,-0.013694501,-0.044693258,-0.069033116,0.08600073,0.03153942,0.0021129397,-0.028197668,0.014004066,0.016238851,-0.016368324,-0.086779505,0.05233257,0.018397067,-0.012604006,-0.03719081,0.03921343,0.01930042,0.07339591,-0.05346768,0.04926282,0.019901847,0.009128296,-0.073670715,-0.01239916,-0.06778516,-0.009524112,-0.064672016,-0.043132816,0.079216585,0.07104463,0.07418734,-0.029883467,-0.003412438,0.018618971,-0.050166868,-0.023097275,-0.07193647,-0.019270873,-0.0013391484,-0.03841552,-0.007702202,-0.03616538,-0.010486044,0.019493578,-0.0012737319,0.022595376,0.03839335,-0.058598552,0.0105938325,0.017257374,-0.015034852,-2.534479e-33,0.057477016,-0.08915468,0.027859598,-0.10368758,-0.014125373,0.02252976,-0.031172,-0.06964981,0.029340282,-0.029384308,0.080037594,-0.07154856,0.053180113,-0.047846816,-0.058548454,0.0023314776,-0.0026864698,0.10937612,-0.08059179,-0.04731016,-0.011569647,0.023726644,0.028948467,0.029435527,-0.0029743707,-0.024693677,0.067538485,0.0058344877,0.031879082,0.10881076,-0.056801546,-0.003615358,-0.08755736,-0.037969995,-0.018700719,0.038578797,0.021782247,-0.071219124,0.024942197,0.034362543,0.004018903,-0.03469252,-0.031468723,0.029208595,0.057360668,0.0476778,-0.05244397,0.10413559,-0.009439478,-0.047462765,0.059505,-0.0026439717,-0.022676032,0.053177316,-0.0102705825,0.010254703,0.06480245,-0.006278481,-0.0070688818,-0.034996666,0.08617184,-0.09130358,0.031442367,-0.02078606,0.051674433,0.024894925,0.032213528,0.10825719,0.036696706,-0.03018651,0.087744825,-0.035488915,-0.012719552,0.05523791,-0.07233964,-0.020290563,-0.030524397,-0.024140095,0.014274378,-0.0344611,0.031042228,0.05742286,-0.018450402,-0.055778615,0.019292602,-0.0143324835,0.060518716,0.112799436,-0.026370585,-0.0415285,-0.029795792,0.04516088,-0.020033492,0.1468156,-0.015176218,-4.4220933e-08,0.026855819,-0.08893372,0.05836634,-0.04165838,0.035411745,0.045221355,0.05384141,-0.049320746,0.0746248,-0.077693634,-0.027998053,0.0948539,0.054427598,-0.0100331595,0.010792866,0.023634672,0.01878382,0.052542873,-0.0034615682,0.0032178792,-0.024146214,-0.045761503,-0.030541023,-0.002749468,-0.033794224,-0.06164044,0.036425028,0.10108559,-0.012367644,-0.013984045,0.022274857,-0.03582636,-0.0017048352,-0.009765525,-0.09976783,0.051638346,0.03353295,-0.06443512,-0.02020303,0.038340148,-0.0919067,-0.01907406,-0.05914135,0.046328027,-0.019538721,-0.0050609084,0.027052395,0.0029955723,0.0022527867,-0.009451729,0.028963493,-0.044087473,-0.03257049,-0.0899764,-0.090167515,-0.018972185,0.0451369,-0.084558666,-0.048971552,-0.032214724,0.007127863,-0.03407201,0.14144693,0.033700038 +4.2.3.155,"The enzyme, characterized from the bacteria Actinosynnema mirum and Stigmatella aurantiaca DW4/3-1, produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.",384,1.0,-0.04235898,-0.0055259187,-0.08900874,-0.02140822,-0.022548258,0.05071702,-0.055111635,0.032715835,0.0388075,0.013687718,0.015592231,-0.09054124,-0.0045138896,0.00054675847,-0.07446229,0.034364715,-0.0965764,0.0307198,0.021902831,-0.013221538,0.056028966,-0.016732868,-0.034607653,0.00035227832,0.038252443,0.03584811,0.07509498,0.028125009,-0.057365775,-0.053663462,-0.0011704244,-0.08219349,0.05701331,-0.14602032,0.055931687,0.10500438,-0.00920453,-0.022566414,0.104587644,0.017400594,0.022490824,0.03754543,-0.002191835,-0.0020898154,-0.0063614827,-0.047394414,0.052916817,0.03528766,0.043569535,-0.06611364,-0.035451118,-0.0382841,0.029058367,-0.0071244696,0.020847725,0.006595059,-0.055623606,-0.003719547,-0.041466426,0.00020937345,0.07609686,-0.034126792,0.063284576,-0.044662073,-0.024898207,0.0014944825,0.048851695,-0.07434404,0.009999264,-0.06816433,-0.058376916,0.0018816004,-0.055825107,0.069705114,-0.033939127,0.06808192,0.044098724,-0.021189058,0.022600632,0.0042738006,0.020991795,0.043211404,0.0340617,0.023794092,0.04852401,0.050316244,0.071766734,-0.027068447,0.036690384,0.0861064,0.009035484,-0.015341977,-0.006169372,-0.013730235,-0.007641215,0.051216688,-0.014862509,0.0067572673,0.09770433,-0.045243576,-0.01743569,0.03867556,-0.079572156,-0.042880647,-0.006487103,0.016411014,0.01689695,0.1067347,-0.07028536,0.014576122,0.034558613,-0.016163163,-0.013073295,-0.024694348,-0.047998823,0.13711019,0.06795931,-0.04046616,-0.057887916,-0.022603154,0.058167227,-0.0016412758,0.021314101,0.030438181,-0.05629916,0.005356746,-0.07940778,1.9618958e-33,0.08223025,0.0821562,0.0037789284,0.019681389,0.029951442,0.0154461125,-0.06539152,-0.0048351525,-0.045239042,-0.107991844,-0.12949747,-0.04436589,0.07006549,0.0033372974,0.027377741,-0.027944565,0.029984284,-0.015594371,0.05052107,-0.025510956,-0.03327447,0.011301569,-0.039195754,-0.008356667,-0.021558184,0.10502929,0.05325545,-0.06245643,0.08329769,-0.011523762,-0.05596525,-0.108151406,-0.06185554,-0.030693542,0.10670602,-0.0072520063,-0.023171913,-0.00371443,0.046632264,-0.0014260578,0.0055580297,0.07874753,-0.025801236,-0.012115374,0.042476445,-0.062533356,-0.08188476,0.03709188,0.040247563,0.023057306,0.036621485,-0.009402781,0.120928,0.002920858,-0.07661901,-0.016938346,-0.012757537,-0.037731424,0.032194052,0.031593576,-0.0040106378,0.10174061,0.017095637,0.060513947,0.020276343,0.013981244,-0.059090663,-0.098154046,-0.019003924,0.07244384,-0.022943953,-0.053251863,-0.009908472,6.4405256e-05,-0.013672319,-0.04075636,-0.0688799,-0.040391546,0.028832762,-0.006086743,-0.04958228,0.042919084,-0.022450779,-0.006122047,0.044566464,-0.008758955,-0.02513307,0.000951519,0.008472072,0.102497555,0.03381982,-0.010073535,-0.06705777,0.0432843,-0.024531025,-2.4805023e-33,0.11655599,-0.08821666,0.08449856,-0.07811286,-0.09646547,0.08883652,-0.042485222,-0.019289134,0.036994893,0.03426928,0.05945503,-0.04314125,-0.020459265,0.009170304,-0.012604046,-0.032532644,0.020726774,0.019079024,-0.030376937,-0.04332951,0.04867636,0.07107411,-0.035490155,-0.034377746,-0.00368029,-0.042796556,0.018893756,0.08660522,-0.0043055206,0.015217645,0.001071742,-0.077548705,-0.05711943,-0.031643983,-0.028660987,0.07863621,0.0017057515,-0.01910609,0.053407796,0.0023796046,-0.012262617,-0.010269783,-0.045784723,0.10400979,0.040084112,0.0711632,-0.05344181,0.06366982,-0.0015816108,-0.031599317,0.052485995,-0.045333702,-0.0130959125,0.02855656,0.016295733,-0.054869406,0.03401465,-0.015468541,-0.041346624,-0.012419853,0.017462602,-0.107438296,0.038076684,-0.010934514,0.042472407,0.10643816,0.026351694,0.044388887,-0.013907498,-0.024002507,0.12209855,0.010634832,-0.0013816446,0.052663404,-0.023867812,-0.0009859191,-0.11716636,-0.044370428,0.05482188,-0.015140309,0.007484445,-0.005450202,0.016741486,-0.03645279,-0.04511732,-0.08551301,0.10029922,0.11017385,-0.06319292,0.08123871,0.0048918496,0.009705681,-0.024305357,0.04046644,0.029815339,-4.8544724e-08,0.061564866,-0.021951895,0.016492216,-0.047887553,-0.05911018,0.027590549,0.000116187555,-0.0242613,0.105677366,-0.078525186,0.015180608,0.038668428,0.03525823,0.011630308,0.05177496,0.044260312,-0.009361637,0.076224454,-0.026696872,0.021942902,-0.03991195,0.025522599,-0.10537733,-0.04126108,-0.015545911,-0.08023937,0.048503224,-0.0003305658,-0.03487686,-0.040757976,0.07081871,0.006963747,0.043189898,-0.038556453,-0.16056845,-0.0017494842,-0.056264263,-0.027529448,-0.0042386437,-0.013838004,-0.019167325,-0.046674497,-0.07179329,0.014207992,-0.01936425,0.020004734,-0.022294896,0.0012819354,-0.03649924,0.0010060894,-0.020623805,-0.0043717325,0.079218246,-0.065252036,-0.14228263,0.06058564,0.01925318,-0.07288107,-0.03721951,-0.03495404,0.011102458,-0.008420179,0.14259157,0.054777358 +4.3.1.31,"The enzyme, characterized from the bacterium Rubrivivax benzoatilyticus JA2, requires no cofactors. It acts on L-phenylalanine and L-glutamate with about 60% of the activity with L-tryptophan, and on L-tyrosine, glycine, and L-alanine with about 30% of the activity.",384,0.99999994,-0.039406475,-0.14907303,-0.12307384,-0.06295636,0.011436936,0.11557139,-0.07372495,0.014035074,-0.033893052,0.0248123,0.05014377,-0.040438145,0.008813319,0.14927582,-0.0065099513,-0.0064560627,-0.026144084,-0.035639085,0.02812901,-0.04129681,0.04105174,0.025260802,-0.013576997,-0.091532715,0.02021828,0.022709742,0.0322057,-0.06977589,0.03048354,-0.047880538,-0.033776995,0.02011345,-0.012209859,-0.09543697,0.033664867,0.019911904,-0.032741215,-0.093364544,0.10894565,0.044398725,-0.048437215,0.050208602,-0.01377626,-0.041479662,0.029916262,-0.024819545,0.119144626,-0.00032075058,0.06534386,0.006505394,-0.07062959,-0.043465134,0.0038886787,-0.02474693,-0.03806193,-0.004409065,-0.048489064,-0.033959594,0.024991605,0.036059104,0.05860447,0.036382873,0.05431229,0.0003209537,0.0063794316,-0.060815725,0.018636705,-0.08492762,0.0122869015,-0.019047393,-0.069581844,-0.07207015,-0.014733177,0.028645923,-0.0034499266,-0.008611284,-0.04474318,0.00926706,0.05333388,-0.063026704,-0.0324071,-0.054527745,0.022449696,0.119614355,0.007783642,0.028906176,0.037444383,0.032466695,0.047754366,0.0919725,0.03163401,0.00461128,0.00068995904,-0.07969252,0.024684504,-0.019267224,-0.013190689,0.08848838,-0.017580122,-0.040781308,-0.031183392,0.032780506,0.009930422,-0.010889616,-0.09832852,-0.032579936,0.0008227073,0.08444885,0.038362555,-0.004283974,0.008787515,0.08948546,0.038130123,-0.073552266,-0.03677727,0.08599744,0.14938441,-0.09721304,-0.038301867,-0.00054333935,0.083881855,-0.03250402,0.072223276,0.061402548,-0.012489362,0.06293581,-0.0837721,2.0355051e-33,0.12596065,0.01478291,0.025194699,-0.01615647,-0.08554654,-0.011264066,-0.12352267,0.008731794,0.001404838,-0.04594797,-0.056530874,0.016018672,0.05472071,0.026251428,-0.025917446,0.061294883,-0.009850258,-0.11340622,-0.008992416,-0.00896886,0.053286698,0.057127632,-0.006585997,0.074218094,0.01822989,0.032346744,0.10818321,-0.0019795466,-0.027816784,-0.016331276,-0.026535016,-0.14246045,-0.05743893,0.038975243,0.05457365,-0.011768622,-0.052309696,-0.027785823,-0.011528173,-0.041245956,0.05573398,0.057805866,0.021741463,0.019628571,0.023596954,-0.05163948,0.0033567154,0.023438876,-0.03141246,0.082517296,0.016902601,0.00041271505,0.06684629,0.016570287,-0.05011612,0.038859222,0.017183375,0.028481817,-0.04728341,0.026116263,-1.604943e-05,0.022903793,-0.02564577,0.03761674,0.02567249,0.049468722,-0.05580507,-0.059113808,0.03035229,0.01852017,-0.061409086,-0.018676715,0.04024465,0.02018862,0.030922338,-0.09202095,-0.035552587,-0.013090394,0.015630953,-0.035626072,-0.002729214,-0.07396245,0.104140595,-0.017656881,-0.035553187,0.007190683,-0.020036545,-0.05121024,-0.04516922,-0.042203892,0.030240398,0.011271539,0.02304518,0.04191231,-0.024220906,-2.8969e-33,0.039682146,-0.08145421,0.044852376,-0.010718688,-0.083126694,0.053108178,0.030300764,-0.077013426,0.0062698154,-0.057620075,0.04599477,-0.01625791,0.050719965,-0.004402046,0.036912683,0.0059551056,0.018668637,0.029545287,-0.035031445,-0.04182983,-0.05630432,0.039371528,0.07022879,-0.009156045,0.079761535,0.0671372,0.0009379377,0.033856947,-0.017823998,0.047046367,0.037672423,-0.00908665,-0.038367413,-0.12044172,-0.05244893,-0.017216569,-0.040125236,0.006551219,-0.016841905,-0.03269553,0.020266848,0.005787727,-0.037377425,0.037061393,-0.0043763705,0.013054167,-0.09786506,0.0011876685,-0.02748206,-0.0361954,-0.012297854,0.014700954,-0.023676356,-0.028975205,0.020613274,0.08056132,0.038399015,0.020637654,0.047357727,0.031105943,0.016369795,-0.048068512,0.0006217568,-0.02805796,0.06677968,0.06506863,0.06841589,0.08202957,0.06709155,-0.0367198,0.059338596,0.050848003,0.0381403,0.061312113,-0.0337353,0.010868867,-0.03272189,-0.018098166,0.042036578,-0.052020818,0.028730264,-0.0099485265,-0.06931053,-0.022670139,0.039080672,-0.05013555,-0.05665486,0.018646004,0.07637294,0.028443964,-0.031092748,-0.021354876,-0.0155176055,-0.007077324,0.05797421,-4.36579e-08,0.012704147,-0.0112154335,0.011214549,-0.020065572,-0.0067839758,0.06368252,0.008837985,-0.046289146,0.06713676,0.011523798,0.034493625,0.026273673,-0.03447061,0.026704311,0.030731063,-0.003705401,-0.06330827,0.056398183,-0.048936628,0.0373678,-0.052491073,-0.06359237,-0.14198679,0.07785748,0.00616234,-0.09463566,0.022566142,0.06506641,0.030583369,-0.022375824,-0.054090142,0.029214578,0.035635803,-0.08736059,-0.20642512,0.0003195445,0.016949052,0.023949405,-0.042114194,0.045979552,0.024697868,0.035601284,-0.09365936,-0.000533394,-0.017718367,-0.013918819,0.022363646,-0.018115869,0.017033793,-0.022178126,0.0693157,0.020103483,-0.013300242,0.02353391,-0.12360358,-0.01977716,0.010315636,-0.07183218,0.051908165,-0.06601905,0.017593782,0.013387034,0.126104,-0.021299118 +4.99.1.9,"The enzyme, present in Gram-positive bacteria, participates in heme biosynthesis. It can also catalyse the reaction of EC 4.98.1.1, protoporphyrin ferrochelatase, at a much lower level.",384,1.0,-0.096327625,0.015027195,-0.08980629,-0.007609937,0.08228752,0.062116545,-0.041874517,0.06453784,0.07938164,-0.005786342,-0.014405779,-0.07666962,-0.07572592,0.056199014,-0.029623384,-0.015995232,-0.08628365,0.065385275,-0.08741587,-0.031093989,0.04643151,0.061609752,-0.006784968,0.0074686687,0.0129632,-0.06497819,0.116512,-0.03535062,-0.0114897285,-0.04964884,0.043209724,-0.032735668,0.07259361,-0.057978768,0.052871328,0.116544835,0.019740501,-0.1156636,0.10418511,-0.030675499,0.039929222,-0.021966724,-0.09143113,-0.05381792,-0.022190958,0.015402195,0.123097464,0.011789572,-0.03797115,-0.04161851,0.0005755522,0.019086787,-0.06495036,0.014524478,-0.036325175,-0.0147779845,0.012005337,-0.047954064,0.0057963547,-0.04076805,0.022433518,-0.019070841,-0.033959202,-0.012010112,-0.023326851,-0.08792652,0.057392634,-0.04210024,-0.0071250503,-0.030993713,-0.0356131,-0.056587182,-0.02132654,0.057122447,-0.05396077,0.062515706,0.025373453,-0.023022396,0.06154945,0.024667967,0.03461581,-0.019206015,-0.0051671457,0.11697237,0.019345935,-0.024990272,0.012508113,-0.021275986,-0.011246753,0.055706173,0.022285575,-0.00803218,0.028874654,-0.04888559,-0.09450603,0.032495745,0.032992646,0.03745164,0.084731266,-0.021728778,-0.028776214,0.08328393,-0.023917284,-0.042224932,0.0012172952,-0.028695777,0.026040455,0.13955411,0.11094102,-0.02840154,0.0467368,-0.073775776,0.06074908,0.00978726,-0.10271255,0.09902419,-0.013447551,-0.07926832,-0.05903297,0.018100927,0.008831416,-0.01872872,0.03880083,0.09638165,-0.054566175,0.02346875,-0.09342204,1.1091043e-34,0.05179934,0.014950498,0.015156131,-0.005823813,-0.022789376,-0.023249902,-0.1360822,-0.033594288,-0.005949952,-0.09005036,-0.048325256,-0.09045908,0.04001476,-0.025061144,-0.026154466,-0.041571744,-0.06410805,-0.038740706,0.010578678,0.065045625,-0.003489319,-0.0045699724,-0.0030711764,-0.006803928,0.04559412,0.05864195,-0.017748162,0.014043216,0.039419018,0.0026871928,0.029658796,-0.056058504,-0.062002778,0.00025315708,0.08631132,-0.004896387,-0.018902658,0.017021177,-0.020226581,0.018237896,-0.04104908,0.070592135,-0.03676182,-0.05343444,0.10679827,-0.07217389,-0.032212228,0.07888318,0.047175653,0.09798371,0.022529757,-0.0043609203,0.12668307,-0.011665301,-0.0040618335,-0.0047147893,-0.0217534,-0.002130967,0.05992543,0.067146055,0.058749374,0.09368345,-0.037302643,0.025586292,0.033577405,0.022448262,0.033419188,0.014283579,0.02571081,0.025348758,-0.04518504,0.021371778,0.05868003,0.005848435,-0.00027588225,-0.0052200495,-0.023878977,-0.01731308,0.020435559,-0.039244983,0.011784576,-0.040638685,0.055424046,-0.027921213,-0.037810594,-0.017677851,-0.06695069,0.0014043279,-0.04713986,0.04165298,0.07634431,-0.10026338,-0.087379895,0.036715284,-0.026249373,-1.1446294e-33,0.112981245,-0.076080985,-0.057475004,-0.11846201,-0.070581496,0.086184286,-0.0072440254,-0.044263974,-0.061662734,0.060154647,0.05894575,-0.0015559517,-0.028008204,0.00016319721,-0.014009079,-0.0024739078,0.019380702,0.04214771,-0.013042028,0.014527063,-0.013217907,0.05273671,-0.0066698915,0.0028909144,0.07649284,0.008068654,-0.017905643,0.06706836,-0.013802249,0.031012867,0.008194966,-0.027540825,-0.026370002,-0.036071423,-0.0376163,0.006885671,0.051328763,0.027547026,0.062114656,-0.02331406,0.042110287,-0.015555888,0.051631935,0.077714115,0.052588936,0.037320327,-0.10763562,0.04561199,-0.011136247,0.0055636563,-0.0027913484,0.05427898,-0.019324942,-0.007048563,-0.014050499,-0.050856266,0.045841355,0.026269201,-0.048898097,-0.029470325,-0.0680619,-0.026617317,0.0663806,0.004043178,0.029472621,0.048818104,-0.07483944,0.11878177,0.0793644,-0.024967972,0.0897452,-0.0022712664,-0.002876383,-0.045672186,0.012143471,0.0074303383,-0.010373452,-0.040311493,0.07752511,-0.03319742,-0.059767332,0.018935699,-0.003134594,-0.09502514,-0.023795541,-0.03287784,-0.007927789,0.101609424,-0.012392272,0.0077279788,-0.030731648,-0.011920949,-0.02339556,0.0021734536,0.040350895,-3.3856466e-08,-0.02520981,-0.06060589,0.02068409,-0.034698125,0.022448212,0.04375228,-0.0036244579,0.0043383786,0.055717893,0.0052011483,-0.030511543,0.07096021,-0.0055381795,-0.0570958,0.035685383,-0.015969306,-0.04522512,0.020984374,-0.050757464,-0.04430626,-0.04739158,0.053422276,-0.10960708,0.0796691,0.040131744,-0.12365872,-0.006409356,-0.011592642,-0.009928111,-0.024211682,-0.008777328,0.04681562,-0.048410486,-0.026587022,-0.023873355,-0.009128245,-0.037849635,-0.010249294,-0.03847198,0.019813597,0.0018307959,-0.0034990904,-0.08383419,-0.028388493,0.010778822,0.1072045,0.042721573,0.02021461,-0.014667585,-0.017549617,0.028306307,-0.042497307,-0.0013711718,-0.0018115711,-0.15256941,0.012237321,0.0060875197,-0.051529076,-0.01668578,0.018144501,0.05258261,0.027996391,0.17397429,-0.019034175 +5.1.3.38,"The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol 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+5.1.3.39,"The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of 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+5.3.1.33,"The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism.",384,0.99999994,-0.018820018,-0.018832888,-0.10812506,0.12108877,-0.0007805561,0.021435324,0.020007301,0.060031626,0.0298566,0.0047052666,-0.030046534,-0.06663898,0.044392295,0.024082923,-0.06221828,0.08127348,-0.03493015,-0.04075196,-0.04384457,-0.0007146584,0.020990383,0.09150163,0.018058686,0.036826022,-0.065152615,-0.06908812,0.041737188,0.033753727,-0.06382683,-0.07326421,-0.06728525,-0.035519384,0.06920367,-0.0050502145,0.06313599,-0.005374832,0.055465233,-0.046572402,-0.009836596,-0.057777748,0.030109413,0.0070484257,0.01861067,0.022786304,-0.010756198,0.017558506,0.0296403,0.013314485,0.0721581,0.047616325,-0.059465904,-0.021474088,-0.014425203,0.065492935,-0.00088310335,-0.045647833,-0.03392829,-0.089369334,0.0072523165,-0.0076034158,0.040080424,0.018511938,0.025483428,0.02485535,0.006179618,-0.006357611,0.006425419,-0.09642731,-0.07517877,-0.028239584,-0.057548508,-0.17868163,-0.05362868,0.054827727,-0.006295003,0.040878795,0.08192632,-0.010604971,0.033206094,-0.02379163,-0.02667214,-0.0015018306,0.07726618,0.0538648,0.05452655,0.08771831,0.021992145,-0.061683275,0.016648753,0.021926152,0.007103666,-0.07951201,0.0102749625,-0.013085185,0.011562033,-0.037415717,0.044288512,-0.074855104,0.008935063,0.03208724,-0.09167922,-0.0063855196,0.029941527,-0.02937581,-0.041408077,-0.030903975,-0.018365955,0.04250273,0.027480057,-0.013911413,-0.011441655,0.043802883,-0.058478788,0.056150485,0.07146836,0.06872984,0.08654554,-0.05605957,-0.117763266,0.003649219,0.018447455,0.009790643,0.011083083,0.023005858,-0.014917845,-0.02598039,-0.026765883,1.1526165e-33,0.008026269,-0.08193459,-0.073363274,-0.014565545,0.066004254,0.0006193053,-0.079897664,0.04671921,0.016156007,0.0025933925,-0.07114621,-0.062959865,0.11678932,0.023182124,-0.006500593,-0.01339091,-0.018978903,-0.014370817,0.06690167,-0.038165532,0.02793536,0.043122754,-0.025572289,-0.061879355,-0.041945327,0.0331835,0.0054013953,0.009324344,0.048958186,-0.0063754553,0.030815288,-0.085876495,-0.06942373,-0.04202209,0.050303325,0.011779342,0.04739252,0.00085609686,-0.027566962,0.021615261,-0.027483346,0.02390586,-0.033775978,-0.0073825424,0.07009092,-0.1077688,-0.038739417,0.072435655,0.035746258,0.034749437,0.033728942,0.003784029,0.114902005,-0.0135011785,-0.066058785,0.05859384,-0.0007243267,-0.019364607,0.037403245,0.031618673,0.037862048,0.04552565,-0.0109836655,0.0004216401,0.0035641438,-0.046526264,0.019116253,-0.015212561,-0.030835086,0.05913375,-0.007505069,0.007876075,0.08237066,-0.030132625,-0.07148183,-0.02501633,-0.0753664,0.052724995,0.07027547,-0.00026453813,0.012295769,-0.047253255,0.012038582,0.049377825,-0.014810848,0.041897085,-0.060782146,-0.018586297,-0.056439873,-0.009397891,0.1409878,0.0101216715,-0.09710337,0.0015546485,0.029834831,-1.549334e-33,0.07192993,-0.06545299,-0.014211219,-0.010218348,-0.03499373,-0.0056138504,0.015245954,0.02159936,-0.038523797,-0.072687685,0.12306841,0.05555216,-0.0002289683,-0.000554088,0.001611584,-0.003764508,-0.015018516,0.023747476,0.008493417,-0.045861505,-0.048675068,-0.0002793405,-0.010626129,-0.13425876,-0.018484723,0.07611191,-0.059759032,0.06216117,-0.0017790954,-0.032180957,-0.019426439,-0.00637727,0.0021828723,-0.13780676,-0.042395603,0.040683605,-0.045995306,-0.0026161226,-0.005078981,-0.0606065,0.049230248,0.030196814,-0.09381984,0.049153086,0.064777,0.15652901,-0.079358004,0.053286616,0.08341841,0.050400198,0.0550442,0.04588524,0.07053168,0.0075299037,0.010461263,-0.0072915237,0.04935073,-0.09923532,-0.07583506,0.040204067,-0.034518175,0.06398658,0.09795357,0.028795326,0.053765193,0.044832993,-0.043434527,0.0004611787,0.04515843,-0.0075157858,0.048838988,0.06320585,-0.043148495,-0.004224499,-0.10520301,0.039999165,0.039105155,-0.035843603,0.007981059,0.007179351,0.020962738,-0.023536777,0.03895109,0.03192714,-0.07788888,-0.07613805,-0.019971507,0.046490327,0.08321136,0.00081088924,-0.010858981,-0.07321153,0.0051627387,0.033001967,0.031843904,-2.4916446e-08,-0.060828056,-0.05546852,-0.025665272,-0.0741839,0.04893115,0.041630957,-0.101642944,-0.0055402652,0.06341166,-0.031530004,-0.02663734,0.08955019,-0.06527926,0.03357031,0.013204683,0.030158442,0.0672203,-0.08157683,0.033541553,-0.042530894,-0.08708129,-0.04003768,-0.014341729,-0.04250118,0.07772021,-0.07396748,-0.06299622,0.0472114,-0.0074594324,-0.0028205558,-0.063192464,0.061886244,-0.008297863,0.012201485,-0.07334257,-0.003837775,-0.043681867,-0.05474005,-0.022692837,-0.015580656,0.05484846,0.029251523,-0.0010057201,-0.022454971,0.027298033,0.025855308,-0.04667509,-0.0021590525,0.035365377,-0.107289724,0.012245264,-0.015186611,0.0810331,0.02473097,-0.091361284,0.06813786,0.004825756,-0.0983111,0.066657476,0.054326978,0.026404982,0.008367697,0.11780145,0.02225097 +5.3.1.34,"The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism.",384,0.99999994,-0.018820018,-0.018832888,-0.10812506,0.12108877,-0.0007805561,0.021435324,0.020007301,0.060031626,0.0298566,0.0047052666,-0.030046534,-0.06663898,0.044392295,0.024082923,-0.06221828,0.08127348,-0.03493015,-0.04075196,-0.04384457,-0.0007146584,0.020990383,0.09150163,0.018058686,0.036826022,-0.065152615,-0.06908812,0.041737188,0.033753727,-0.06382683,-0.07326421,-0.06728525,-0.035519384,0.06920367,-0.0050502145,0.06313599,-0.005374832,0.055465233,-0.046572402,-0.009836596,-0.057777748,0.030109413,0.0070484257,0.01861067,0.022786304,-0.010756198,0.017558506,0.0296403,0.013314485,0.0721581,0.047616325,-0.059465904,-0.021474088,-0.014425203,0.065492935,-0.00088310335,-0.045647833,-0.03392829,-0.089369334,0.0072523165,-0.0076034158,0.040080424,0.018511938,0.025483428,0.02485535,0.006179618,-0.006357611,0.006425419,-0.09642731,-0.07517877,-0.028239584,-0.057548508,-0.17868163,-0.05362868,0.054827727,-0.006295003,0.040878795,0.08192632,-0.010604971,0.033206094,-0.02379163,-0.02667214,-0.0015018306,0.07726618,0.0538648,0.05452655,0.08771831,0.021992145,-0.061683275,0.016648753,0.021926152,0.007103666,-0.07951201,0.0102749625,-0.013085185,0.011562033,-0.037415717,0.044288512,-0.074855104,0.008935063,0.03208724,-0.09167922,-0.0063855196,0.029941527,-0.02937581,-0.041408077,-0.030903975,-0.018365955,0.04250273,0.027480057,-0.013911413,-0.011441655,0.043802883,-0.058478788,0.056150485,0.07146836,0.06872984,0.08654554,-0.05605957,-0.117763266,0.003649219,0.018447455,0.009790643,0.011083083,0.023005858,-0.014917845,-0.02598039,-0.026765883,1.1526165e-33,0.008026269,-0.08193459,-0.073363274,-0.014565545,0.066004254,0.0006193053,-0.079897664,0.04671921,0.016156007,0.0025933925,-0.07114621,-0.062959865,0.11678932,0.023182124,-0.006500593,-0.01339091,-0.018978903,-0.014370817,0.06690167,-0.038165532,0.02793536,0.043122754,-0.025572289,-0.061879355,-0.041945327,0.0331835,0.0054013953,0.009324344,0.048958186,-0.0063754553,0.030815288,-0.085876495,-0.06942373,-0.04202209,0.050303325,0.011779342,0.04739252,0.00085609686,-0.027566962,0.021615261,-0.027483346,0.02390586,-0.033775978,-0.0073825424,0.07009092,-0.1077688,-0.038739417,0.072435655,0.035746258,0.034749437,0.033728942,0.003784029,0.114902005,-0.0135011785,-0.066058785,0.05859384,-0.0007243267,-0.019364607,0.037403245,0.031618673,0.037862048,0.04552565,-0.0109836655,0.0004216401,0.0035641438,-0.046526264,0.019116253,-0.015212561,-0.030835086,0.05913375,-0.007505069,0.007876075,0.08237066,-0.030132625,-0.07148183,-0.02501633,-0.0753664,0.052724995,0.07027547,-0.00026453813,0.012295769,-0.047253255,0.012038582,0.049377825,-0.014810848,0.041897085,-0.060782146,-0.018586297,-0.056439873,-0.009397891,0.1409878,0.0101216715,-0.09710337,0.0015546485,0.029834831,-1.549334e-33,0.07192993,-0.06545299,-0.014211219,-0.010218348,-0.03499373,-0.0056138504,0.015245954,0.02159936,-0.038523797,-0.072687685,0.12306841,0.05555216,-0.0002289683,-0.000554088,0.001611584,-0.003764508,-0.015018516,0.023747476,0.008493417,-0.045861505,-0.048675068,-0.0002793405,-0.010626129,-0.13425876,-0.018484723,0.07611191,-0.059759032,0.06216117,-0.0017790954,-0.032180957,-0.019426439,-0.00637727,0.0021828723,-0.13780676,-0.042395603,0.040683605,-0.045995306,-0.0026161226,-0.005078981,-0.0606065,0.049230248,0.030196814,-0.09381984,0.049153086,0.064777,0.15652901,-0.079358004,0.053286616,0.08341841,0.050400198,0.0550442,0.04588524,0.07053168,0.0075299037,0.010461263,-0.0072915237,0.04935073,-0.09923532,-0.07583506,0.040204067,-0.034518175,0.06398658,0.09795357,0.028795326,0.053765193,0.044832993,-0.043434527,0.0004611787,0.04515843,-0.0075157858,0.048838988,0.06320585,-0.043148495,-0.004224499,-0.10520301,0.039999165,0.039105155,-0.035843603,0.007981059,0.007179351,0.020962738,-0.023536777,0.03895109,0.03192714,-0.07788888,-0.07613805,-0.019971507,0.046490327,0.08321136,0.00081088924,-0.010858981,-0.07321153,0.0051627387,0.033001967,0.031843904,-2.4916446e-08,-0.060828056,-0.05546852,-0.025665272,-0.0741839,0.04893115,0.041630957,-0.101642944,-0.0055402652,0.06341166,-0.031530004,-0.02663734,0.08955019,-0.06527926,0.03357031,0.013204683,0.030158442,0.0672203,-0.08157683,0.033541553,-0.042530894,-0.08708129,-0.04003768,-0.014341729,-0.04250118,0.07772021,-0.07396748,-0.06299622,0.0472114,-0.0074594324,-0.0028205558,-0.063192464,0.061886244,-0.008297863,0.012201485,-0.07334257,-0.003837775,-0.043681867,-0.05474005,-0.022692837,-0.015580656,0.05484846,0.029251523,-0.0010057201,-0.022454971,0.027298033,0.025855308,-0.04667509,-0.0021590525,0.035365377,-0.107289724,0.012245264,-0.015186611,0.0810331,0.02473097,-0.091361284,0.06813786,0.004825756,-0.0983111,0.066657476,0.054326978,0.026404982,0.008367697,0.11780145,0.02225097 +5.3.3.20,"The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, uses radical chemistry to rearrange the positions of both a methyl group and a hydroxyl group. It consists of two subunits, the smaller one containing a cobalamin cofactor. It plays a central role in the degradation of assorted substrates containing a tert-butyl moiety.",384,1.0,-0.032091644,-0.025706535,-0.085481636,-0.024743307,0.010589324,0.03334765,-0.050258234,0.05298239,0.048874136,-0.051226616,0.03714115,-0.010551706,-0.02182263,0.053085703,-0.072533526,0.03420055,-0.060005,-0.017418133,0.028526217,-0.050652657,-0.0471901,0.037926923,-0.0141908685,0.031291187,0.06629739,0.02233612,0.020890791,-0.030280448,-0.037825305,-0.030273922,0.036835413,0.07718231,0.04366619,-0.00577071,-0.051700614,0.097290255,-0.035408203,-0.053805992,0.07793856,0.008183426,0.044840813,-0.00813138,-0.06606108,0.025524855,0.023168812,-0.028856505,0.041847926,0.08198598,0.049871564,0.012889153,-0.040462386,-0.033865232,-0.0699232,0.095129095,-0.04926607,0.035357118,0.047452085,0.012344032,-0.014724252,0.019388443,0.0838994,0.034972277,-0.01541996,0.0561809,0.0046512187,0.005693941,0.035829023,-0.048765674,0.017105168,-0.008698669,-0.02725146,-0.08648659,0.021435034,-0.010757759,-0.014552586,0.009255823,-0.010978254,-0.07439669,0.017815268,-0.028917653,-0.0023708704,0.0067013116,0.058948033,0.09584729,0.078454904,-0.052474573,0.021283405,-0.033427566,0.082169406,0.009352933,0.0018924718,0.04446844,0.018882727,-0.046770044,-0.059145097,0.01635056,0.028752308,0.033510786,0.050183304,-0.031475823,-0.014620644,0.04171647,-0.017668927,-0.103331834,-0.10089193,-0.027109167,-0.02029662,0.109018825,0.100528866,-0.0028823663,-0.026921025,0.013537618,-0.0041880575,-0.054359995,-0.010058788,0.07477048,0.073168926,-0.020742359,-0.11053835,0.016125958,0.014793545,-0.02266829,0.043644294,0.022699608,-0.06527777,0.027104478,-0.13699962,1.0848608e-33,0.065121114,0.014318437,-0.038426228,-0.010274183,-0.0016094377,-0.010595198,-0.08825813,0.03828342,-0.07053189,-0.03430516,-0.023263413,-0.037944734,0.017660413,0.048999287,-0.02109097,-0.04631957,-0.0005701597,-0.010726448,0.031559236,-0.0004414204,-0.055972688,0.11774611,-0.05395158,0.019369714,0.021074126,0.07215944,0.033480637,0.073058836,-0.031410765,0.018065877,-0.011793844,-0.09148157,-0.2005806,-0.020572534,0.09823848,-0.0081771035,-0.07502224,0.0053894916,0.010418235,0.05059361,-0.0036868148,0.07887587,0.03304619,-0.023422167,0.07784535,-0.045143735,0.008115764,0.13616922,0.02600159,0.043940634,0.006734039,0.020551994,0.07337196,0.0039306837,-0.066231474,0.020216087,0.03394683,0.056232832,0.0139960395,0.010005065,0.048184324,0.013813739,-0.046340734,0.07617395,-0.03238701,-0.005549529,-0.05812712,0.011289311,0.030667383,0.037296496,-0.084518455,0.057674833,0.046855178,-0.011499246,0.02824822,-0.041420743,-0.026800325,-0.04199248,0.04827471,-0.07811013,-0.08644557,-0.051656615,0.04433073,-0.051635105,-0.1135253,0.014723957,0.031632736,0.028210243,-0.05065609,-0.01666465,0.025894731,-0.004870799,-0.03774563,-0.02102038,0.05474351,-1.3524812e-33,0.040590055,-0.09208379,0.0042959806,-0.09683891,-0.049183708,-0.013153246,0.012579762,0.0030893988,-0.0018840703,0.003707848,0.091644436,0.019565938,0.010126737,-0.05176658,-0.022029938,0.074403845,0.037247512,0.079562426,-0.04691033,-0.07215264,-0.0017599078,0.045324557,-0.015307609,-0.05347299,-0.042477053,0.06787998,-0.0020457448,0.0087397015,0.11390991,0.07163152,-0.04149985,0.0052111303,-0.017595826,-0.0598559,-0.009842367,0.08174383,-0.034734838,-0.008606356,0.019371916,0.00418475,0.082951605,0.031576786,-0.015530179,0.07545734,0.051868908,0.06749961,-0.068271734,0.025321491,-0.015512833,-0.036086258,0.10064826,-0.01249112,0.036391944,0.001570903,0.031381987,0.015093709,-0.0015000366,-0.07035481,-0.043328222,-0.099854134,-0.010132199,-0.06616024,0.045148734,0.017420137,0.009481454,-0.008499043,-0.02659819,0.042496428,0.024288874,-0.020209102,0.076331936,0.052377958,-0.027489673,0.03153531,-0.050623268,-0.04870364,-0.052038513,-0.017449992,-0.02601214,0.0028659033,0.02209186,-0.057394028,0.006351338,-0.09535995,-0.004672642,-0.050912052,0.0058442256,0.11629485,-0.025245424,0.058522392,-0.05050668,-0.00010881322,-0.07642281,0.04424788,0.104814574,-4.157635e-08,-0.00052246626,-0.09472858,0.029236153,-0.033618465,0.03332446,0.09807875,-0.010791761,0.024363857,0.0645687,0.006902286,-0.0027106507,0.08119901,-0.02994335,0.069863714,-0.018795762,0.01742005,-0.009690598,-0.034483343,-0.04097084,0.0045518624,-0.05134022,0.010969062,-0.07593481,-0.0026447703,-0.0018731992,-0.042586666,-0.050672423,0.019742396,-0.044240974,-0.0539528,-0.01786129,0.06993652,-0.027512092,-0.025157025,-0.1219895,0.02718305,-0.04389125,-0.012351554,0.0038615623,0.08089518,-0.03228862,-0.022435581,-0.122992426,0.0670297,0.026056645,-0.05708495,0.045828108,0.029399576,-0.046015073,0.020222804,0.038779683,-0.02682208,0.0156032145,-0.04092238,-0.101671465,-0.0043706563,0.0026726075,-0.047319826,-0.036009625,-0.09033887,0.02082174,-0.0023103254,0.17695098,-0.1011916 +1.3.1.112,"The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway. It catalyses the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols. The enzyme catalyses sequential hydride transfers to C-2 and C-4, respectively. Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers. cf. EC 1.3.1.77, anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming].",384,1.0,-0.028441526,0.008041207,-0.18854077,0.0030073354,0.093054265,0.09659877,-0.03774312,0.027003886,0.0262142,-0.077970184,0.021206077,0.020560116,-0.05960061,-0.06446659,-0.05439829,-0.019785816,-0.10066982,0.039586484,-0.02032963,-0.079618745,0.033884086,-0.023274986,0.04035921,0.0059205075,0.04104043,-0.026022227,0.023373773,-0.027928863,-0.0621108,-0.038185026,-0.00405365,-0.03176437,0.04375056,-0.06233941,-0.053016156,0.035946235,-0.008923084,-0.105359845,0.00069687667,0.03859081,0.015116444,0.04161441,-0.02802041,-0.0032504057,-0.012115545,0.041607853,-0.0019981642,0.056069814,0.065038376,-0.01365053,-0.06364368,0.011279613,-0.046202075,-0.03655496,0.046064336,0.009424372,-0.009639984,0.0368793,0.0456421,0.0684021,0.052854013,-0.017304117,0.04463825,0.008793472,-0.04400689,-0.059334017,-0.023999138,-0.0056158686,-0.006178471,-0.01724432,-0.08056616,0.023691393,-0.06401952,-0.022238951,-0.0056043314,0.097185776,-0.012094021,0.06463365,-0.0162155,0.009865422,-0.0011365017,-0.030667545,-0.066297464,0.08465689,-0.012252345,0.0021211456,-0.07248459,-0.022723358,0.01995415,0.12089492,0.024988865,-0.011043671,0.010172735,-0.032576077,-0.08304883,0.049762644,0.10599566,0.01021506,0.042399485,0.007169505,-0.07373701,-0.018641084,0.036796134,-0.0507022,-0.08582858,0.026737478,-0.059347402,0.070838146,0.029365653,0.038536545,0.033183094,-0.010111185,0.029342692,-0.052781273,-0.04226001,0.14236937,-0.022850718,-0.007901512,-0.0632793,-0.0043479246,-0.0154748205,0.027278032,0.0927752,0.041667927,0.012568363,-0.07571453,-0.05969791,2.7790701e-33,0.04048374,0.0355164,-0.027128967,0.00041443802,0.008481684,-0.028262421,-0.033774134,0.032487344,0.048547134,-0.022910178,-0.07818225,-0.06483121,0.071113095,-0.033582978,-0.06257688,-0.030768907,0.022502694,-0.09770699,0.016516088,0.008008524,0.060553927,-0.02172395,-0.07091727,0.04582278,-0.07541712,-0.013177655,0.03143608,0.0025103085,0.03855624,-0.009071071,-0.035323635,-0.11574235,-0.024536729,0.032363664,0.051541507,-0.033112194,-0.0658313,-0.08721446,0.008826995,0.03643906,0.034184348,0.0064006774,0.03988032,0.018943354,0.048265167,0.029444443,-0.04341606,0.09506242,0.0046872753,0.07448582,-0.03472619,0.011011417,0.14482358,0.033964437,-0.05758702,0.017304923,-0.004281453,-0.02587229,-0.021006493,0.012725132,-0.003405066,0.051039252,-0.011993442,0.01828945,-0.0970192,0.041756216,-0.0774133,-0.05945083,0.05994999,0.026815385,0.015393487,-0.054486368,0.040977683,0.019406307,0.07505651,-0.013625932,-0.07276304,-0.055183876,0.037198287,0.022108603,-0.103840075,0.0584272,0.0432475,0.034354616,-0.0008896279,-0.038749788,-0.05050857,-0.018412406,0.007320594,0.032661468,0.0524609,-0.048439287,0.026283702,0.026055036,0.062002067,-2.630373e-33,0.06203354,-0.019188588,0.054387063,-0.04874038,-0.008494981,0.03428467,0.036753092,-0.038181603,-0.05168412,-0.08392861,0.0072236885,-0.034498565,-0.010786295,-0.02653844,-0.017416859,0.023288842,0.053373195,0.06687831,-0.054693256,0.03548376,-0.06733415,-0.0022276642,0.0033622722,-0.016573958,0.03562242,-0.036968663,0.035452917,0.015928546,0.013941139,0.1147241,-0.00855582,-0.05030048,-0.08466712,0.02530504,0.016184893,0.0743149,6.0428552e-05,-0.011092378,-0.002657567,0.035117466,0.020671407,-0.055609357,-0.07712911,0.07297133,0.01778231,0.11442926,-0.0874719,0.12657778,-0.032358427,-0.005090325,0.028831594,0.08714805,-0.002826913,0.08424648,0.01750105,0.04924254,0.08076402,-0.011740374,0.02069066,-0.013488582,0.014087003,-0.10682949,0.042515937,0.017940084,0.02100987,0.01780143,0.08760024,0.09188345,0.04046032,-0.11361136,0.09225587,-0.025930466,0.0896851,0.10617379,0.020616392,-0.07159546,-0.01981648,-0.04572613,-0.05005088,-0.007983039,-0.0025511603,-0.012513815,-0.026693724,-0.0234712,0.010398202,-0.018452877,0.008211787,0.05873517,-0.033051718,0.086514354,0.008780402,0.067034386,-0.015940554,0.09155803,0.06271072,-4.038526e-08,0.0017140291,-0.074958056,0.04829695,-0.012829453,0.03215704,0.037033476,-0.06276671,0.078882016,-0.013858274,-0.02257464,-0.023570964,0.07082071,-0.0068667713,0.0049543185,0.0344583,-0.00020253166,0.053995788,0.046700623,-0.03614788,0.026115019,-0.073452994,-0.025707014,-0.16944155,-0.0355572,0.0040493323,-0.11074252,-0.04319583,0.016896803,0.046747923,-0.07650756,0.019109365,0.031324495,0.005902376,0.015089685,-0.119187534,0.0050012246,0.013513437,0.0038378185,-0.029013783,-0.007132655,-0.0690034,-0.002697043,-0.028558614,0.010318977,-0.0065252143,-0.031116365,-0.0019413872,0.04962279,-0.008414159,-0.0022856756,0.0542198,0.023936667,0.06548947,-0.04526898,-0.04885254,-0.045426145,0.03204728,-0.0408657,-0.026965104,0.012205787,-0.088376194,0.011048813,0.13453357,-0.016442122 +1.14.11.54,Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA [2].,384,1.0,-0.024705168,-0.013244009,-0.03738821,0.07142723,0.05583815,0.03888157,0.019978212,-0.016181601,-0.044246435,-0.08274113,-0.023700705,0.065090455,-0.02962336,-0.054865804,-0.040973928,0.095104195,-0.035355564,0.008085943,-0.053384762,-0.032722037,-0.0075404956,0.07727913,0.08187967,-0.05414168,0.0070714494,0.0464617,0.05114683,0.017238494,0.029691381,-0.05812693,0.021598957,-0.016018728,0.010754866,-0.02812055,0.027467232,0.025825232,0.0046878383,-0.06544781,-0.0070962147,0.034031756,0.026824148,0.007460746,-0.05046947,0.02177958,-0.0016926002,-0.0467788,0.036722668,0.0007987465,-0.0047491738,0.10936657,-0.020501344,-0.014638552,-0.0033593823,0.07199385,0.0579531,0.02427543,0.011332799,-0.01794596,-0.030381978,0.07870266,0.0861277,-0.01227405,-0.047996856,-0.021513443,0.053760774,-0.009220257,0.09968899,-0.032780435,-0.042895705,-0.06795903,-0.019436195,-0.01946226,-0.07325365,0.009095924,-0.047966063,0.014605443,0.08863038,-0.12508398,0.06113383,0.018413868,-0.03263366,0.013363945,0.05864704,0.086883426,0.04109291,0.067668594,-0.03567681,0.041955616,-0.016581113,0.058061037,-0.03764136,-0.014984158,0.012783322,-0.019535394,-0.041078243,0.06357174,0.015891604,0.07894859,0.013583053,0.0077468003,-0.031964198,0.050467882,-0.070717596,-0.08173391,-0.02975268,0.03932529,0.0120569905,0.097368374,-0.013147883,0.04603007,0.00048145597,-0.008397395,0.046002403,0.035559874,-0.027579056,0.0046972013,0.076436564,-0.010426877,-0.06609512,-0.048749976,0.043942034,0.036286,0.041878615,-6.953162e-05,-0.057361133,-0.035780333,-0.1021471,1.5250985e-33,0.031863634,0.017378418,0.009938124,0.04541623,0.00097487174,0.025432954,-0.09848692,0.024655478,-0.01921232,-0.002474376,-0.050707657,-0.07343526,0.038513474,-0.022489574,-0.04275492,-0.07061693,0.015413902,-0.02806073,0.044119332,-0.046706744,-0.0021860283,0.049758982,-0.007175652,-0.03948172,-0.04900106,0.011141723,0.056636505,0.0055874106,0.021076795,-0.033318713,-0.06823609,-0.06444449,-0.08071794,0.0073175295,0.041494407,-0.013642074,0.028340565,-0.035871714,-0.008852692,0.057634808,-0.020920964,0.036346592,0.010672365,-0.05226493,0.048553318,-0.048925538,-0.123914525,0.03869615,-0.018612407,0.027977142,0.030368805,-0.014745619,0.06491058,-0.041493583,-0.08433791,0.010868468,-0.070833206,-0.011261916,0.023245778,0.101326145,-0.047325145,-0.06879072,0.06672919,0.014827138,0.053940643,-0.059825722,-0.07252812,-0.016811842,0.017533027,0.045814965,-0.022804927,0.015321056,0.10891556,0.0059211846,0.0058166115,-0.027537163,-0.08278385,0.009331124,0.055765774,0.05312601,-0.0014203938,-0.054343015,-0.0009273603,-0.044737626,-0.018196214,0.021744514,-0.0056601698,-0.07786604,0.044272598,-0.033622693,0.002568458,-0.033629254,-0.063056745,-0.11638007,0.033222802,-3.031787e-33,0.045142278,-0.09042682,0.035914186,-0.057644274,-0.039985664,-0.03500396,0.022005402,-0.050810408,-0.027178584,-0.026643643,0.07390037,-0.020712579,-0.019206537,-0.120248556,-0.005787555,0.02166536,0.014092844,0.11041917,0.06310363,-0.018931191,-0.012532575,0.078489766,-0.04472589,0.067387894,0.03884091,0.0044500493,-0.053762846,0.014364003,0.16168748,0.09375214,0.014494686,-0.018637327,-0.03366153,-0.009326303,0.03917333,0.06419065,0.07289649,-0.017944692,0.004807193,0.018108709,0.022028096,0.02766983,-0.012842291,0.13864382,0.06111298,0.05970102,-0.14660181,-0.0049492074,0.0076206247,-0.030167386,0.08351545,-0.0455681,-0.025240887,0.061545685,0.09263039,0.008727473,0.08570476,-0.0033288565,-0.02854861,0.02580295,-0.085156396,0.022879342,0.053008392,-0.039508928,0.049077664,0.021576237,-0.04305451,0.0780901,0.0071048117,-0.06294179,0.09276493,0.053133957,0.007287708,-0.025440285,-0.0012667718,0.0023892683,-0.028954817,-0.0024083192,-0.10405688,0.0133397095,0.011932525,-0.04895413,-0.0551839,0.017180912,-0.015196992,-0.053946972,0.061249804,0.067627475,-0.071001895,-0.0703294,-0.06633402,-0.055684425,-0.049913242,0.041957732,-0.015925746,-2.912024e-08,-0.07007647,-0.05660582,-0.023257967,-0.10143332,-0.011191796,0.060491733,-0.023672309,0.018799737,0.03678655,0.0062523102,-0.008240077,0.09522567,-0.020834273,0.015761567,-0.012986848,-0.003068217,-0.040507294,0.043131072,-0.0027558522,0.014271704,-0.056548834,0.07088721,-0.066484086,0.023491496,-0.05889259,-0.032386884,0.002182483,-0.019339975,0.06344419,-0.06189176,-0.0088147465,0.02181407,0.060996365,-0.07783821,-0.05355935,-0.06716701,0.114433736,-0.04883893,0.005255378,0.032969378,0.0034274107,-0.028388051,-0.047433905,-0.009952283,-0.009642409,-0.06572287,0.022072721,0.030286014,-0.07293006,-0.047124688,0.102093905,0.01995239,-0.0044732867,-0.070450455,-0.09417231,0.040338308,-0.026141675,-0.019541612,0.083420135,-0.013975408,-0.0076045017,0.0030006578,0.19556743,-0.092894316 +1.14.13.222,"The aurachin C monooxygenase from the bacterium Stigmatella aurantiaca accepts both NADH and NADPH as cofactor, but has a preference for NADH. It catalyses the initial steps in the conversion of aurachin C to aurachin B. The FAD-dependent monooxygenase catalyses the epoxidation of the C2-C3 double bond of aurachin C, which is followed by a semipinacol rearrangement, causing migration of the farnesyl group from C3 to C4.",384,1.0,-0.0868502,-0.001624059,-0.053501986,-0.012220679,0.047466584,0.13704297,-0.048675653,-0.010942718,0.037235875,0.011867068,0.038498215,-0.122573756,-0.11576326,-0.010732425,-0.02427136,0.03989961,-0.031697907,-0.00787943,0.0034595751,0.008538927,-0.051694117,-0.04085331,0.024936767,-0.02971573,0.08251999,-0.0050134836,0.0026690916,-0.042241704,0.012041555,-0.062258944,0.004851658,-0.01804368,0.011427207,-0.013368493,-0.0019915306,0.055331618,0.0005163065,-0.07730533,0.09042136,0.021289835,-0.009980654,0.07029655,-0.07013362,-0.0015319573,-0.021444822,-0.00972523,0.051874198,-0.0034972946,0.055282637,-0.023318075,-0.018998208,-0.052410733,-0.087934874,0.047616635,-0.0192314,0.044915058,-0.018082557,0.004115247,0.002427384,-0.029591985,-0.0021991837,-0.07991567,0.04729732,0.043605242,0.038715675,-0.06796874,0.0056380187,-0.038108896,0.024309002,-0.08876391,-0.073198676,-0.0052005034,-0.061907254,-0.010908795,-0.0058848658,0.09233013,-0.070382364,-0.016684754,0.036892045,-0.02341925,0.014708216,0.08334915,0.024068018,0.09557139,0.03195584,0.015346638,-0.026153112,-0.0067665083,-0.0149778705,0.01786892,0.034388226,-0.047239553,0.0176247,0.030793577,-0.09892453,0.0017545564,0.15475269,0.02376748,0.05922748,-0.038295068,-0.004854588,0.0811235,0.0017192208,-0.11352992,-0.08717576,-0.026375057,-0.093955256,0.11003526,0.018665515,-0.059176374,0.0074852197,0.002621391,0.03202029,-0.026374953,-0.049983263,0.0531345,0.0060901097,-0.07307352,-0.070898116,-0.012579804,-0.007566254,-0.016386833,0.025805172,0.025878375,-0.010975177,-0.0038575372,-0.05943415,4.988407e-33,0.08712523,0.046122473,-0.004528116,-0.010168624,0.00039943057,0.033395045,-0.073597305,0.0031881423,-0.08987955,-0.001109085,-0.058873996,-0.008821855,0.062407624,-0.026366932,-0.0003630749,0.032135986,-0.06684802,-0.06899243,0.03564985,-0.057270624,0.017840946,0.04594901,-0.031838194,-0.017250117,0.008764775,0.02958162,0.027452413,0.052461177,0.028567225,0.010804719,0.035717964,-0.032500308,-0.0778741,-0.0314791,0.04715031,0.016044924,-0.04087973,-0.05354776,-0.013933955,0.013469577,-0.023930816,0.039796006,-0.09051035,-0.057181556,0.084931605,-0.12497159,-0.076057784,0.043096624,0.059833102,0.051843133,-0.026192635,-0.027287558,0.145952,0.064506285,-0.02416175,0.030032111,0.009522122,-0.04781549,-0.01525095,0.05716506,0.050595835,0.015398551,-0.04853569,0.08712752,-0.021055128,0.04195265,-0.117914736,-0.0023403952,-0.024783552,0.0822425,0.01888055,-0.036101386,0.02891994,0.0059697144,-0.020500485,-0.03211379,-0.075623855,-0.031256158,0.011270932,-0.04768682,-0.082430825,0.02788157,-0.013199913,-0.035369586,0.004108496,0.020802347,-0.0042172293,-0.059540205,-0.024300963,0.080663286,0.11458315,-0.053042766,0.0033995812,-0.035870172,-0.032508075,-5.0912853e-33,0.102345854,-0.019804077,-0.052055016,-0.14755218,0.013875246,0.06842824,0.06903912,-0.033892855,-0.022789156,-0.013020204,0.025689818,0.07776113,0.02246397,0.05219431,0.05178942,-0.020469079,0.045871433,0.0352487,-0.026702303,-0.0114988815,0.04763201,-0.022263866,-0.03959714,-0.012858759,0.023586534,0.024196925,-0.03600701,0.089351445,0.058121376,0.043138877,-0.027863376,-0.012081691,-0.03934685,0.03064119,0.044878997,0.0022352354,-0.066253245,0.03899462,0.025761645,0.0373347,-0.022685494,-0.06596672,-0.09063407,0.04837591,0.13116038,0.07646474,-0.16069776,0.020618513,0.047096156,-0.06489839,0.0077668424,0.021864401,-0.0038280727,0.019940626,0.018425843,0.03218993,0.04189713,-0.044985708,0.06754519,-0.07822263,-0.0038985927,-0.06458229,0.08503824,-0.001283951,0.039309878,0.024487682,0.006279897,0.04733108,0.011350256,-0.06208767,0.10481819,0.04473579,0.02176164,0.042122062,-0.02538761,-0.03065594,-0.024415107,0.014155708,0.031694267,0.004395777,-0.0060244193,0.021057531,0.066188745,-0.0032288749,-0.031054685,-0.03167348,0.02484675,0.042219747,-0.021768887,0.044960674,-0.03888183,0.049644407,0.024851464,0.042250354,0.12873916,-4.0033033e-08,0.016788382,-0.02258774,0.083942845,0.007058206,-0.04339426,0.06089954,0.044162966,-0.016130311,-0.008011375,-0.043705907,-0.0025441318,0.1279294,0.10313316,0.0420397,0.034530222,0.023582665,-0.011440636,-0.04818892,-0.040154785,-0.0698921,-0.13012819,0.015785486,0.0028906278,0.045875516,-0.02812823,-0.06867091,-0.027326182,0.018673021,-0.035942223,-0.030448377,-0.036013868,0.010081606,0.065012425,-0.010218547,-0.08785953,0.020522596,-0.04771041,0.004527965,0.004470274,0.007883632,-0.0125520965,-0.036940366,-0.09362811,0.01909698,0.044123378,-0.008560414,0.05688761,-0.03265885,-0.037332848,0.0510367,0.06617938,-0.041753314,-0.011228558,-0.019379623,-0.105156526,0.018538672,-0.09183447,-0.0029263464,-0.04909929,-0.05027213,0.014453596,0.046329252,0.09430246,-0.024634048 +1.14.13.223,"A flavoprotein (FAD). The enzyme, characterized from the bacterium Streptosporangium sibiricum, is involved in the biosynthesis of the antitumor antibiotic sibiromycin. The enzyme is not active with free 3-hydroxy-4-methylanthranilate.",384,0.99999994,-0.087806776,-0.04268449,-0.14627646,-0.019244941,0.09837269,0.0011043461,-0.02506099,0.097340785,0.071549565,-0.04855479,0.0067618685,0.028323855,-0.072413884,-0.018465152,-0.08769499,0.031528056,-0.05497086,-0.01827161,-0.009474062,-0.03246636,-0.019272085,0.027895918,0.06016641,-0.034723092,0.02868649,-0.028019287,-0.0026564267,-0.032127038,-0.031519637,0.0014248531,0.12593837,0.07004214,0.07657386,-0.027744109,-0.022925615,0.06692536,0.036449604,-0.021252448,0.02611741,0.032828636,0.014489497,-0.02150564,0.06066461,0.014806576,0.07421518,0.028666029,-0.04799699,0.08029865,-0.011024422,0.032926653,-0.034603577,-0.046593543,-0.12452032,0.07048233,-0.0102426885,0.022008544,0.0067596026,-0.07356732,-0.012242415,0.0075724404,0.02321034,-0.01326659,0.050733883,0.010360769,0.024671886,-0.041125257,-0.04973775,-0.069311365,0.065278776,0.0032042332,-0.0067638475,-0.019809961,-0.037199628,0.07422798,0.0030114076,0.017285593,-0.070964225,0.023397682,0.058669318,-0.031987242,0.093490094,-0.0073681874,0.076519,0.06198219,0.054615464,-0.023410507,0.012641689,-0.0126722595,-0.008189314,0.062404588,0.008196089,0.0015067818,-0.028452335,0.009117555,-0.096716926,0.03964894,0.023141723,-0.08329627,-0.06033486,-0.009125069,-0.056380853,0.006846413,0.032827973,0.0048030596,-0.072459444,-0.07573579,-0.038538232,0.07094188,-0.038489334,-0.046107337,-0.022428064,-0.025080903,0.016510801,-0.091118775,-0.0019734325,0.009516595,0.01183926,-0.066056915,0.003987214,-0.013692742,-0.03978573,0.108174756,0.02498438,0.079069406,0.05308083,-0.004365379,-0.1255375,3.6164705e-33,0.07200095,0.015052086,-0.029106012,-0.021469468,-0.008199974,-0.014614748,-0.0561393,-0.015051548,-0.0103297345,-0.022674669,-0.044245422,-0.05205132,0.0006107153,-0.008900007,0.07262935,0.013008238,-0.03217716,-0.014975775,0.087988235,-0.11925705,0.032811172,0.05891372,-0.04477188,0.042104457,0.05497633,0.039465364,-0.068324834,0.0555781,0.051863,0.025847903,-0.03087579,-0.040185686,-0.063313805,-0.01769645,-0.005970704,0.04399498,-0.09740325,-0.104308516,-0.062485863,0.090065576,-0.008444088,-0.014182218,-0.00966534,0.014237629,0.032219023,-0.021233402,-0.07628199,0.081169225,0.02693674,0.06931878,0.039796073,-0.047660884,0.11366027,0.07949945,-0.084486276,0.016987484,-0.04618528,0.017048413,-0.0039971713,-0.020901985,0.018573742,0.029297976,-0.02735021,0.09895684,-0.0805461,-0.024922892,0.003599738,-0.05728971,0.027199436,0.12834103,-0.0023861486,-0.0049782586,0.068561465,0.0071703186,0.04793658,-0.02790285,-0.018617967,-0.054857973,-0.015104411,0.024887819,-0.045741513,-0.035669047,-0.01994127,-0.045068227,-0.025527522,0.030458204,-0.035575785,-0.035660695,0.010405545,0.010798539,0.0029401067,-0.056199376,-0.0099389665,0.060417924,0.027356766,-3.1906675e-33,0.03977312,-0.09967187,0.081223145,0.031899016,0.0062190304,0.06459457,0.028617676,-0.027522532,0.019922711,-0.03479027,0.020553712,-0.067483746,-0.020141406,-0.013949099,0.073458195,-0.003199728,-0.05870038,0.012074012,0.034641314,0.053694777,-0.036102746,0.021868458,0.033679128,0.043691713,0.02135179,-0.002276153,0.026380746,-0.023243045,-0.01403827,0.03415366,-0.03902155,0.0028537035,-0.08967148,-0.023480574,-0.08009438,0.040129676,-0.000473491,0.027760966,-0.0071212817,0.009643283,0.014564132,0.018590538,-0.030398967,0.060502395,0.041057993,0.044766754,-0.007020805,0.06026742,0.09281703,-0.058990005,-0.0063628624,0.024982125,0.02808888,0.06258093,0.04188204,0.023731677,0.03288676,0.04587742,-0.03496577,0.003898006,0.011685846,-0.1273712,0.03466518,-0.006876896,0.1274537,0.09521685,0.051016383,0.14558342,0.010879429,0.00456034,0.12943277,0.0041195,-0.012233961,0.08621135,0.0228395,-0.02937828,-0.03077523,0.047945593,0.0071501504,0.04882174,0.037787315,-0.022020748,0.012532423,0.06180096,-0.0961954,-0.10527978,0.007913815,0.06296903,0.015728103,0.02657035,-0.029010613,0.072456084,-0.0007555913,-0.046731725,0.030685214,-3.6604273e-08,0.017034886,-0.03800982,-0.01839401,-0.035241313,0.08546968,-0.0035084318,-0.091747895,-0.046008117,-0.016877253,-0.025062546,-0.08908403,0.11465939,-0.041630376,-0.029798217,0.04851273,-0.05419768,-0.015238533,0.010349592,-0.0202204,-0.011179254,-0.08227841,0.07026711,-0.10240454,0.0033094215,-0.044183824,-0.020662373,0.020950438,-0.004768087,0.04908643,0.025946284,-0.008608539,0.027669728,-0.013358592,-0.029563889,-0.13517256,0.035617854,0.00654238,-0.09657997,0.008256393,0.024698012,-0.017923106,0.015712459,-0.0074037206,-0.029896282,-0.043291613,0.005306015,0.033070028,-0.045838065,-0.08744025,-0.014425111,0.0084342975,-0.0034609444,-0.011837055,0.035622265,-0.086237036,-0.0075340793,-0.026459873,-0.084226385,-0.041153546,-0.08202743,0.009018962,-0.0038284773,0.17555846,0.017156105 +1.14.13.224,"The enzyme, characterized from the bacterium Chromobacterium violaceum, participates in the biosynthesis of the violet pigment violacein. The products, violaceinate and deoxyviolaceinate, undergo non-enzymic autooxidation into violacein and deoxyviolacein, respectively.",384,1.0,-0.0502899,-0.024038687,-0.09622223,0.01405695,0.014827829,0.06888037,0.005963009,0.020214109,0.009422795,0.022717802,-0.01279904,-0.08059977,-0.07020839,-0.0029749617,-0.10889745,0.10485047,-0.068989106,0.029331535,-0.06190812,-0.0286773,0.031909473,-0.007196166,-0.041282494,-0.003407763,0.000898471,0.056712396,0.0035392297,0.015702626,0.08214203,-0.045476507,-0.06409461,-0.06962896,0.12241584,-0.028181067,0.06277518,0.043320723,-0.00094028877,-0.112539314,0.032593705,-0.024614057,0.046286494,0.04064834,-0.07576529,-0.0076623755,-0.021932643,-0.016337013,0.06418551,0.02011925,0.012742855,-0.047218718,-0.031490862,-0.046468385,-0.06872763,-0.010456186,-0.045207053,0.037451897,0.060432322,-0.03816519,0.019531015,0.03466024,0.045804393,0.002433136,0.06639591,0.055784866,-0.017076448,-0.027535735,0.028512716,-0.019587131,-0.032765582,-0.10657741,-0.046438497,-0.106817536,0.00025965113,0.06369883,-0.0068028565,0.056593847,-0.01048931,-0.029646393,0.007886789,-0.01692356,0.048349373,-0.0683855,0.0077281566,0.15516897,0.0487493,-0.005854947,-0.038221274,-0.038785573,0.0319904,0.070168525,0.007179097,-0.012898011,0.0022697407,-0.10868755,-0.044404242,0.014678487,0.08271219,-0.056302007,0.06833701,0.0097152535,-0.073347576,0.05833727,0.009622743,-0.09564662,-0.02232684,-0.043149885,-0.026648514,0.08966001,0.045424536,-0.024991976,-0.007984403,0.04692029,0.018961556,0.010582315,0.0013972024,0.08792372,0.014557484,-0.038522966,0.016288234,0.06340513,0.039231513,-0.05437058,0.055466775,0.03489749,-0.004500102,0.0011954757,-0.04800481,2.9408584e-33,0.06279238,-0.00059465814,-0.0203319,-0.025281502,-0.029515805,0.03670942,-0.07599992,0.004875423,-0.005285936,-0.020411504,-0.076337956,-0.07923997,0.061852254,0.031442575,0.04087052,0.013975942,-0.011068244,-0.057360694,0.002086444,0.023484189,0.03351788,0.035871856,-0.09552035,0.046509724,-0.018220177,0.06395545,-0.019678093,0.043711763,-0.003991133,-0.011007934,0.027433276,-0.0012340388,-0.07379045,-0.01849463,0.10179739,0.018766297,-0.021742353,-0.004881682,-0.03895863,0.08439223,-0.01884663,0.050560266,-0.05111725,-0.031561177,0.08683442,-0.07353381,-0.025674319,0.056790005,0.08563707,0.0634985,-0.0190341,0.03966259,0.09980665,-0.07043259,-0.010853984,0.06420832,0.0609238,0.0044225007,0.0339426,-0.012014886,-0.02846971,0.019958833,-0.03907676,0.05687326,0.063879564,-0.0009430078,-0.0018319475,-0.08437836,0.012165393,-0.01652369,-0.07045467,0.004406606,-0.028218698,-0.047152,-0.0047503705,-0.06305324,-0.047804266,0.0042730654,0.047788136,-0.07769243,-0.013674417,-0.015796132,-0.012774865,-0.1017924,-0.0029564924,-0.016245382,-0.02792729,-0.021930173,-0.048563626,-0.010698178,0.12694435,-0.028319718,-0.07329061,-0.03813505,-0.011024245,-4.0515147e-33,0.054587375,-0.040909536,-0.02082861,-0.02643442,0.028755454,0.08890453,-0.02625533,0.04415185,-0.03161179,0.0034111724,0.07411494,0.050860133,-0.0042030066,0.034780346,-0.020870255,0.047098715,0.024564395,0.081179276,-0.02089537,-0.04905766,-0.029400995,0.07242468,0.09761281,-0.066673055,0.043904305,0.0019534475,-0.005224692,0.06857003,0.042374272,0.039031938,0.021918416,0.029974004,-0.026502363,-0.0010591557,0.008245584,0.021743715,-0.012177737,-0.008949385,0.005748989,-0.003209901,0.035787746,0.010490649,-0.039875098,0.0695229,-0.0121541675,0.08361156,-0.12258058,0.0032034593,0.019040398,-0.039527573,0.019384911,0.0023664944,-0.0026418027,0.022763722,0.018183395,0.010069499,0.04932662,0.010376754,-0.037935924,0.06847238,-0.024804577,-0.026767278,0.07334787,0.025465554,0.018264018,0.06808966,-0.006663944,0.13310947,0.022621455,-0.0730792,0.06697497,0.024565771,-0.023182558,0.01237111,-0.033521574,-0.04091126,-0.046152007,-0.023656277,-0.021564126,-0.036374602,-0.010120418,0.030861504,-0.006072104,-0.034786124,-0.10849462,-0.100331925,-0.059222598,0.08542579,-0.011229394,0.0390301,-0.020594452,0.022524856,-0.045217726,-0.0030057828,0.13124016,-3.3261603e-08,-0.024275705,-0.046587516,0.077184565,-0.024785902,0.052612722,0.0058192806,-0.034863207,-0.01208212,0.009435192,-0.018191623,-0.02268961,0.043203756,-0.01609726,-0.008284582,0.016487904,0.049632624,0.01046098,-0.017284868,-0.030545324,0.091326475,-0.017401975,0.00091666664,-0.06617735,-0.00048381032,-0.0008740441,-0.09733706,-0.041837137,0.005444927,-0.012062149,0.035534326,0.04275142,0.0806593,-0.004811896,-0.06627165,-0.19665477,-0.015056976,-0.041656535,-0.12929113,-0.06637498,-0.03042798,-0.013326321,-0.009789425,-0.115516305,-0.024470689,-0.017793635,0.028140033,0.04436646,-0.0020209975,-0.017268194,-0.015708452,0.021413613,-0.070644945,-0.015105273,0.0056815883,-0.094415694,0.013793956,0.090000585,0.013825312,-0.024101276,0.011285986,-0.00959771,0.008822933,0.23201522,-0.050974872 +1.14.13.225,"The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization [1]. Free methionine is not a substrate [2]. The reaction is stereospecific and generates the (R)-sulfoxide [3]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1) [4,5]. ",384,1.0,-0.05112139,-0.036219433,-0.059261497,0.020536646,0.072971165,0.063743316,-0.032844845,0.04479738,0.023854714,0.009528837,0.013564902,-0.026655221,-0.10879886,0.09041232,-0.038738858,0.0849248,-0.083778,-0.01782139,-0.0074560074,-0.022455016,0.082613856,0.048771095,0.012701859,-0.004714615,0.034053613,-0.040427424,-0.009779957,0.0044963947,-0.035420086,-0.098871715,-0.025552455,0.029765755,0.038262654,0.028534587,-0.0011363107,0.026471308,-0.0016924121,-0.051215827,0.027694095,-0.05388463,0.08102827,0.040617913,-0.05513147,-0.018975435,-0.025663488,-0.006914613,0.039725788,0.0217191,0.08497407,0.01124433,-0.07131877,-0.053993244,-0.0011615597,0.065286145,0.064699076,0.019261079,0.041156158,-0.028419206,-0.020634722,-0.053271785,0.008502564,-0.038151275,0.01169733,-0.030792166,0.036528043,-0.07345636,-0.03538216,-0.08620661,0.029652987,-0.04688795,-0.06157922,-0.0048655374,-0.0006025883,-0.02419751,0.0038940276,0.04504436,-0.031241586,-0.029946884,0.019033333,0.02702254,0.018816609,-0.0041914643,0.02190305,0.091532044,0.043736905,-0.0047182897,0.010231519,-0.045151148,0.050619658,-0.0020562664,-0.062672615,-0.00863976,-0.04678629,-0.0060332404,-0.09254962,-0.0153246345,0.019590752,0.00159074,-0.072664306,0.05190065,0.00824015,0.06647034,0.013519383,-0.09410191,-0.12204281,-0.02007762,0.02427103,0.08763733,-0.018845838,-0.0010600162,0.022825489,-0.020750787,0.083800256,0.075551115,-0.064028725,0.016997416,-0.03930489,-0.042223424,-0.027551247,0.006838134,0.025465017,0.036515124,0.017397227,0.028647665,-0.003737818,-0.06398133,-0.16461168,1.1785436e-33,0.102032505,0.07153775,-0.010874655,-0.021028036,0.019209964,-0.048228998,-0.08152312,0.040297315,0.025555417,-0.01448204,-0.057479884,-0.031664077,0.045388076,0.0022470115,-0.0188799,-0.042910554,0.03232002,-0.029986717,0.07481426,0.044032834,-0.027703399,0.0014859971,-0.059055578,-0.061563827,-0.0038153029,0.014463145,-0.09161308,0.002154129,0.018212123,0.015157146,0.020969363,-0.025546882,-0.047779925,0.09688708,0.070211425,-0.009798393,-0.09192245,-0.059090115,-0.03535175,0.026162444,-0.017608985,-0.008943569,-0.01598276,-0.029625913,0.058456406,-0.09587971,-0.07464093,0.12757802,0.04710725,0.13570008,0.028165799,-0.06541102,0.19287317,-0.08825501,-0.04435554,0.017912868,-0.058258414,-0.05928148,0.032683693,0.04808382,-0.017649574,0.004728889,-0.082108244,0.06399874,-0.049191847,-0.0028492715,-0.047529887,-0.056397974,-0.014678126,0.06780371,0.01597717,0.03180693,0.020185111,0.026162127,-0.009878318,-0.026253061,0.026514575,-0.00025477243,0.040767763,-0.005924528,0.007249201,-0.053961515,-0.043781444,-0.051502254,-0.05805053,0.043158706,0.019620685,-0.015959777,-0.010244729,0.052623797,-0.0036161193,-0.085087575,-0.021895519,-0.040382877,0.078747466,-1.6901278e-33,0.036425214,-0.06837003,0.0031052479,-0.08769779,-0.0199769,0.07261505,-0.0062677544,-0.04041045,0.020518132,-0.06308399,-0.040331274,0.010786494,0.002616564,-0.070888944,0.0862571,-0.010539336,0.028899824,0.019468503,0.030300006,-0.013270735,-0.00594214,0.14771971,0.013506928,-0.008456326,0.028950753,-0.03562277,0.00050630554,0.0837691,0.07089619,0.024574561,-0.05404041,-0.009690213,0.0020500151,-0.038289554,0.00059226167,0.038615584,-0.076194115,-0.027174711,0.10231607,0.022162963,0.01938387,0.03239637,-0.04689249,0.04748048,0.07686364,0.06398404,-0.08731777,-0.0048600407,0.060700648,-0.07200311,0.011530104,-0.008509198,-0.02309583,-0.08287372,0.046562664,0.0712743,0.045195017,-0.010596308,0.030859252,-0.04046291,-0.012213797,-0.0912002,0.007480025,0.04795758,0.025562385,0.055163227,0.058781914,0.06594481,0.034608766,0.011824836,0.07796299,0.025642136,0.028194439,0.053484246,-0.07910632,-0.07900161,-0.04561306,0.06597571,0.00898077,0.00073654857,0.006098621,-0.0098389415,-0.02992033,-0.08920494,0.018336784,-0.045735586,-0.0130172195,0.067773074,-0.021104945,0.010931226,0.0004231866,0.04392332,0.0025990775,0.060898956,-0.0074490006,-4.537049e-08,0.12221908,-0.03984419,0.057638142,-0.010160345,0.039712798,0.047579776,0.047810648,-0.043189365,0.031330712,0.044885203,0.0051660473,0.048362836,0.039421193,0.019537803,0.047935203,0.008689022,-0.0013885129,0.076010875,-0.059050057,0.03466034,-0.06931723,0.028209599,-0.11924957,0.077688485,-0.014992174,-0.075377226,0.0068608513,0.0071810912,-0.037247833,-0.04802106,0.03464113,0.06679834,0.04902071,-0.057558477,-0.15386282,-0.0045121824,0.0048082126,-0.042289946,-0.034369074,-0.00050778623,-0.009880109,0.029043874,0.00803617,-0.0082237935,-0.0037927297,-0.010990911,0.0532328,-0.062317356,-0.032312986,0.018370224,0.06336408,0.08128228,0.010590501,-0.042492248,-0.1374634,0.041329604,0.06287567,-0.08399659,-0.022212263,-0.036883105,0.0548616,0.0074297246,0.11647597,-0.019283572 +1.14.13.226,"Contains FAD. The enzyme, characterized from the bacterium Gordonia sp. TY-5, is a Baeyer-Villiger type monooxygenase and participates in a propane utilization pathway.",384,1.0,-0.09571623,-0.036677487,-0.08938404,-0.006873194,0.118207864,0.018048031,-0.026493233,0.037520785,0.023526171,-0.0078350315,-0.027385859,-0.041944165,-0.102322206,0.012356535,-0.046317138,-0.0025485654,-0.01886489,-0.052385878,-0.012505712,-0.08341439,0.02956648,0.08084271,0.0746025,-0.018526403,0.012564594,0.010271253,-0.005228378,-0.0019911104,-0.025784539,-0.009395654,-0.010115842,0.056123454,0.0048345453,-0.06687046,0.029155333,0.083519004,0.007936506,0.0061845784,0.07803048,0.022631226,0.023808187,-0.08494337,0.01983274,-0.040887717,0.017524369,0.034909166,-0.024187969,0.041873842,0.02430496,-0.0826622,-0.040609878,-0.074349485,-0.007607081,-0.024853127,0.052873924,-0.014134537,-0.017961241,-0.11126743,-0.025337389,-0.044534456,0.011992602,0.024321042,-0.011607113,0.028627798,-0.025892152,-0.014400107,0.01061175,-0.065440334,0.044250786,-0.098029755,-0.030410346,-0.093457244,-0.034372512,-0.020301279,-0.043416586,-0.0018856305,-0.007983107,-0.09285204,0.12875998,-0.0422303,0.01064529,0.028054772,0.0772115,0.07101474,-0.00011954169,-0.018459503,0.04634993,0.0065692253,-0.003155169,0.03873785,0.014080014,-0.035105783,0.0028364677,-0.04772382,-0.059003934,0.029082825,0.06440494,-0.029506672,0.030733876,-0.008563758,-0.06395619,0.049023464,0.0037878032,-0.019237882,-0.10733927,-0.02026777,-0.014904919,0.17633949,0.032254755,-0.07184608,0.006226933,0.007135688,0.052026182,-0.030233737,-0.021330277,-0.049414933,-0.018717103,-0.062377065,-0.0022487587,0.02650539,-0.013188821,0.035517257,0.044439513,0.08762862,0.016495897,0.038656212,-0.08254547,-3.0572806e-34,0.04680458,-0.0198156,-0.013596983,-0.015250025,0.050156143,0.022202548,-0.061151065,0.007456369,-0.021406405,0.0023009114,-0.066565685,-0.07465775,-0.038826916,0.009718852,-0.041770607,0.030356618,-0.07378012,-0.004474032,0.017735453,-0.06217605,0.011041045,0.07994136,-0.010456715,0.009184526,0.017276065,0.00718001,-0.021104246,0.020478971,0.036991064,0.023123346,0.027536007,-0.07420867,-0.11348249,-0.0051205447,0.023455717,0.03276517,-0.035138022,-0.044646215,-0.14466773,0.018221803,-0.0052085775,0.08787454,0.006954014,-0.024926407,0.00560767,-0.06717681,-0.034288857,0.12479375,0.032507904,0.10276509,0.05087849,-0.006829717,0.063004844,-0.011408269,-0.07601383,0.06943588,0.0136830965,0.07140264,0.070134096,0.035769455,-0.011337569,0.07560121,-0.02156136,0.04302366,0.026483066,0.01780051,-0.0077009844,-0.02828129,0.01603509,0.15348475,0.02095832,0.027636841,0.07200144,0.028389663,0.06928252,-0.03260943,-0.000343904,-0.04941471,-0.015147234,-0.024690755,-0.04698623,-0.087880194,0.064454794,-0.013797777,-0.06364496,0.02294813,-0.026186803,-0.094539724,0.007950306,0.020807289,0.047484588,-0.11237643,-0.035671987,0.05422556,-0.0017124279,-3.5696265e-34,0.080268815,-0.076407865,0.051343583,-0.08295953,-0.049691554,0.08310901,0.0008376449,-0.06396933,0.011567706,-0.028588183,0.12972687,0.033133343,0.027502466,-0.029616699,0.02000353,-0.036886375,-0.0068783094,0.03885376,-0.013349039,0.047752235,-0.053092394,0.026766649,-0.0046983557,0.01000688,0.05640136,0.023612667,-0.070384204,0.07844378,-0.03747478,0.034170073,0.055896875,0.0512615,-0.036343176,-0.02603073,-0.044869184,0.036279224,-0.010495877,0.032005664,0.0025705728,0.042183615,-0.034966655,-0.0037810716,0.005370905,0.10240941,-0.009186787,0.07625753,-0.06566476,-0.0036163847,0.07382451,-0.0068484116,-0.0005376014,-0.012588295,-0.019438468,-0.021155743,0.0008447018,0.049241886,0.057985537,0.039003104,-0.04896154,-0.021711225,0.0258368,-0.046155494,0.090350084,0.058639724,0.08934382,0.025499012,-0.032840524,0.03870246,0.0839537,0.009546441,0.069410644,0.036424354,0.029802512,0.04635186,-0.009436067,-0.05275212,0.0006968976,0.0065421266,0.05149266,0.018361434,0.04956691,-0.009351619,-0.051706053,-0.018506892,-0.0825985,-0.10137699,0.040312007,0.09578305,0.042743,0.06105238,-0.026539134,0.07069953,-0.059940174,-0.022890134,0.090972945,-3.1786037e-08,0.022830773,-0.05840935,0.027117778,-0.025906501,0.013452342,0.038237393,-0.009540739,-0.007828354,0.01431772,-0.02909243,0.0071842005,0.09425005,-0.03312672,-0.049099986,0.039354853,-0.055844817,-0.07934406,0.0023242317,-0.046494633,-0.027143136,-0.041543983,0.0012131946,-0.053984743,-0.0251261,-0.010794574,-0.08339806,0.043703035,0.010728974,0.03635207,-0.02325247,-0.034654062,0.07765131,-0.032117527,-0.01987859,-0.09465306,0.06262297,-0.005447184,-0.016166268,-0.09905913,0.062222224,0.0064186794,-0.030816257,-0.09560914,-0.059553217,0.003233735,0.03083768,-0.0185352,0.044780366,-0.039490923,0.0023998097,0.061811294,0.012955743,0.0422652,0.067069516,-0.1426176,0.021415902,-0.011381459,-0.047392294,-0.0074343295,-0.067711964,0.02575256,0.01759375,0.1862034,-0.04732324 +1.14.13.227,"The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase.",384,1.0,-0.057568256,-0.07868263,-0.11282368,0.027745493,-0.0042050625,0.036313493,-0.090413325,0.009875511,0.006380837,-0.09393844,-0.014164627,-0.06616508,-0.035044093,0.07108053,-0.059575494,0.005794396,-0.070188805,-0.02402235,0.016290369,-0.08662986,-0.0122653125,0.021889819,-0.027486471,-0.056626126,0.026100546,0.01945763,0.0488937,-0.021402357,-0.0767614,-0.046420816,0.042490985,-0.00038874804,0.10688498,-0.018470617,0.040901434,0.07074081,-0.025447335,-0.021489639,0.078443676,0.024732238,-0.03520014,0.018691156,-0.011816523,-0.047208376,-0.04311532,-0.014523051,0.0079482505,0.0029660196,0.048878524,-0.003923105,-0.06811442,0.0023955244,-0.023369947,0.039182,0.06631,-0.021979198,0.033158205,-0.10370182,-0.06282135,-0.01383643,0.020754093,-0.053526957,-0.016304238,0.03084184,0.0152691025,-0.020928467,0.036661055,-0.09211901,0.0047370414,-0.061960112,-0.082594715,-0.06827135,-0.027817184,0.033775076,-0.04053742,-0.036143135,0.030362343,-0.045004863,0.10751175,0.0009271445,-0.018268125,0.07592056,-0.0034178642,0.057647455,0.06359597,-0.03357362,0.028149929,-0.03214782,0.033155873,0.07733971,-0.067176275,-0.020853208,-0.0025221244,-0.07673477,-0.02626278,-0.00016463132,0.063113645,0.020615947,0.049604047,-0.015708456,-0.0027340734,0.06120132,0.03801989,-0.09417164,-0.04033582,-0.036353126,0.02427308,0.13426283,0.03659619,0.0010845121,0.03976614,0.021089084,0.041428976,-0.024010848,0.009576029,0.06467596,0.056828085,-0.056010943,-0.08753949,0.097936556,0.05066494,-0.034740716,0.080121554,0.023007352,0.028860511,0.006880914,-0.10075398,1.5767572e-33,0.029532092,0.048358977,-0.026594386,-0.011325524,0.042658526,0.00336953,-0.0861108,0.035831917,-0.07987621,0.002134516,-0.0011540896,-0.0055199065,0.029310236,0.075594045,-0.007545766,-0.04153865,-0.052691374,0.021206612,0.0025206094,0.041690663,0.01358662,0.06618855,-0.0068074507,0.06105278,0.007914716,0.023138031,-0.020330159,0.048220564,-0.001335381,0.0034705296,0.034109656,-0.0814848,-0.10501457,-0.034525312,0.08044258,-0.049403843,-0.031872027,0.007355866,-0.033173393,0.04966383,-0.014478895,0.052695278,-0.023441931,-0.06360972,0.05064258,-0.08797765,-0.082767904,0.14355172,0.02668999,0.077792466,0.023641147,-0.021265332,0.12248661,-0.048489757,0.0009716057,0.09088811,-0.036096048,0.029459894,0.051933732,0.051762056,0.012856492,0.053853877,-0.05444067,0.04898645,0.023189586,0.009300845,-0.0016863315,-0.04338994,0.067079514,0.11604616,-0.0091658,0.04217652,0.031031646,0.04844875,-0.02056477,-0.05741853,-0.049243156,-0.02821301,0.071870595,0.010988511,-0.051420394,-0.009059855,0.026618911,-0.038209632,-0.10794903,0.033013992,-0.012335543,-0.025016911,-0.050559085,-0.023007952,0.043310914,-0.032734346,-0.06485447,-0.050170556,0.032704264,-3.7292364e-33,0.09388961,-0.07530131,0.004107491,-0.124713354,-0.08719339,0.08616234,-0.0004607746,0.0026557385,-0.022417132,0.04731458,0.09842965,0.040756993,0.037045285,-0.04130407,0.019824568,0.04949942,-0.006545778,0.05058793,-0.013077693,0.039929543,0.0027961144,0.05383513,0.010334029,-0.060533434,0.030176768,0.012019478,-0.10436573,0.06356977,0.041362863,0.07259301,-0.031793516,0.034552295,0.01693349,-0.09082266,-0.0017999859,0.047942795,-0.058919847,0.0015493422,-0.0017972705,-0.01096491,0.022682415,0.017206453,0.0068380516,0.09587513,0.063080855,0.022655595,-0.11889987,0.057898518,0.01137112,-0.053125117,-0.023294387,-0.010442116,-0.0043849437,0.0050648265,0.006117522,0.014469636,-0.008752097,-0.03405084,-0.0023178097,-0.023136033,-0.04511171,-0.09614468,0.08082125,0.07287612,0.03789156,-0.017943515,-0.049488783,-0.01824443,0.011537267,-0.007954297,0.03825868,-0.005148857,0.04551988,0.00017606124,-0.007356369,-0.059210435,-0.07673205,0.028273955,-0.032135732,0.0476078,0.028832352,-0.044376373,-0.03245948,-0.048999473,-0.06251842,-0.12966926,0.018123286,0.06696387,0.0034701233,0.02847507,-0.042138763,0.007126213,-0.08107377,-0.025325438,0.00059874344,-4.054319e-08,0.035880167,-0.065806165,0.06751474,-0.06730445,0.023434646,0.056285206,-0.017632296,-0.057109103,0.045366585,0.0036330817,0.045503985,0.113384694,-0.0013370949,0.0078974385,0.039190713,0.032167844,-0.038058143,-0.0019342653,-0.011488249,-8.4223626e-05,-0.020922378,-0.0072890176,-0.05201591,0.05509486,-0.013152414,-0.041061,-0.00026537658,0.0065248683,-0.029461807,-0.050448254,-0.068669446,0.09281709,0.016252205,-0.059590712,-0.12577891,0.023023361,-0.0551234,-0.010145526,-0.012365402,0.04588802,-0.0024731362,-0.016320007,-0.13481654,0.018587066,0.014841522,0.071866706,-0.029557642,-0.013156264,-0.028613904,-0.04006162,0.008983403,0.020825952,0.031792793,0.023275346,-0.08323124,0.12592055,0.01503215,-0.08326648,0.030318897,-0.02646583,0.0020371657,0.05718438,0.14943926,-0.046663553 +1.14.14.30,"The enzyme, characterized from the bacterium Streptomyces viridifaciens, is part of a two component system that also includes a flavin reductase, which provides reduced flavin mononucleotide for this enzyme. The enzyme, which is involved in the biosynthesis of the azoxy antibiotic valanimycin, has a similar activity with either FMNH2 or FADH2. It exhibits broad specificity, and also accepts propan-1-amine, butan-1-amine, butan-2-amine and benzylamine.",384,0.99999994,-0.052821163,-0.019193508,-0.19624296,-0.015749542,0.08113095,0.011917039,-0.036843892,0.0652061,0.07414315,-0.051644173,0.016186185,-0.010233109,0.046817835,0.08641621,-0.055271883,-0.026945872,-0.108329505,0.00595632,0.039628748,-0.012970229,0.0017033454,0.096430145,0.022235427,-0.0053144656,0.0077331355,0.027999584,0.012709663,0.06747564,-0.035108972,-0.060132828,0.12321507,-0.036680054,0.07745936,-0.048372272,0.04146324,0.087156884,-0.011611192,-0.06465414,0.039526742,0.010250067,-0.060271516,0.019631345,0.04431443,-0.002775528,0.030011598,0.04123672,0.0027645566,0.058902085,0.018156238,0.015175535,-0.0568814,-0.046126053,-0.059772056,0.10190864,0.07665703,0.07103808,-0.11036452,-0.03497871,-0.06830441,0.004515106,0.049877968,0.05572811,0.010787739,-0.023933249,-0.024313856,-0.030053092,-0.01660433,-0.094247185,0.02578672,-0.062462557,-0.058010798,-0.032777917,0.009917216,-0.011276426,-0.03175079,-0.014173576,0.004828549,0.00019762314,-0.014312729,-0.016056972,0.037081525,-0.01453387,0.002215763,0.08272786,0.046708312,-0.035643205,0.030986425,-0.012068416,0.065826595,0.11922144,0.05998052,0.037788138,0.03617105,-0.09329005,-0.030493522,-0.012902852,-0.0115490705,0.031589214,0.03489979,0.014118227,-0.034483477,-0.0060561635,-0.0053243386,-0.042373568,-0.04449175,-0.04144847,0.04349083,0.07627373,-0.020364707,-0.06354882,0.037349243,0.0128050335,0.022624874,-0.06578504,-0.026599005,0.08965592,0.08268102,-0.075167045,-0.12005569,0.02948511,-0.021944277,0.02124321,0.05667407,0.04409598,0.010210585,-0.021973323,-0.12915982,1.5095933e-33,-0.0008147604,0.07596818,-0.05323872,-0.04570472,0.030765912,0.016288288,-0.037333127,0.034486238,-0.008001778,-0.06975226,-0.09069561,-0.04123988,0.05105813,0.035987165,0.017871803,-0.052233584,-0.023650354,0.0009578914,0.038531337,-0.035892636,0.062815115,0.0022682056,-0.002536265,0.030300986,0.050619446,0.034815636,-0.016415076,0.0171742,0.042437352,-0.01218046,-0.010024908,-0.07909562,-0.07395113,0.026233032,0.07244611,-0.008051669,-0.11658603,-0.032859188,0.030913305,0.06758567,-0.009218911,0.011124329,-0.024396654,0.01967524,0.04621131,-0.040474556,-0.084230945,0.092264205,0.05779051,0.02083933,0.04780741,-0.040197957,0.05431674,-0.029407568,-0.07253202,0.059072524,-0.030595945,0.034792315,-0.01926052,0.028065903,-0.004672579,0.013467195,-0.008701711,0.019431133,0.03051426,-0.004641271,0.01812534,-0.08055595,0.04136547,0.07167262,-0.023425765,-0.0077866362,0.06271973,0.018044142,0.04852652,-0.025210762,-0.041236155,-0.031201765,0.07762502,0.019786866,-0.081644975,-0.013444103,-0.018118924,-0.03892124,-0.030970288,-0.0035038379,-0.021036439,-0.08466925,-0.008449132,0.068509325,0.008985854,-0.12090093,-0.060985733,-0.04692067,0.08623841,-2.2875728e-33,0.05469894,-0.091966644,0.050352704,-0.043512587,-0.03772014,0.06880479,0.0016634025,-0.04328705,0.017408691,0.009053087,0.077582896,-0.035520993,-0.04056622,-0.03632274,0.005366037,0.01309245,0.032763153,0.06019926,0.03468626,0.039281182,-0.01442177,0.07221826,0.020199278,-0.01369321,-0.011538015,0.01213182,0.022661071,0.032884754,0.06348849,0.09095313,-0.0512083,-0.03363331,-0.0666185,-0.086910516,-0.017470008,0.108554095,-0.042692505,0.0014065114,-0.024021918,-0.033929005,0.092524774,0.006366506,-0.011209728,0.033728026,-0.046636708,0.06123285,-0.0792569,0.029640857,-0.015287907,-0.12360103,0.0057802587,0.023749469,-0.015073572,0.038892534,0.00015546776,-0.0048075933,0.010822072,-0.00062182406,-0.0057303854,-0.03146313,-0.0017908085,-0.11932548,0.0070117093,-0.026584946,0.05679448,-0.014552445,0.06737062,0.03478298,0.079495095,-0.022719517,0.057776935,-0.044083092,0.0930811,0.06611231,-0.0571684,0.0029550304,-0.035346933,-0.013714576,0.039150164,-0.044166937,0.07669225,-0.020161852,0.0003302204,-0.05900739,-0.027880978,-0.04027512,0.024650289,0.052085713,-0.0054104584,0.040753372,0.02030044,0.053017978,0.01247024,-0.020798901,-0.002821659,-4.25469e-08,0.03856477,-0.095527045,0.041035112,-0.047773182,-0.0029472488,0.047190845,-0.028293004,-0.0013328508,-0.0098663075,-0.016766643,0.010242713,0.112141624,0.026013091,-0.06972,-0.003838377,0.023982782,-0.06914379,0.048560493,-0.02194252,0.009605931,-0.071932584,0.028901454,-0.14156207,-0.027700653,0.02384154,-0.0024154943,-0.04098363,-0.010015517,0.02287414,-0.026647037,0.085238464,0.016480168,0.011861692,-0.009897072,-0.1504658,-0.06241318,-0.007968245,-0.060073562,-0.045874923,-0.011263541,0.03911462,0.009971606,-0.08271846,0.01703993,-0.04734435,0.027320776,-0.004819285,-0.0026496814,-0.06417887,0.0142792165,0.06112996,0.013611039,0.01876022,0.0031791239,-0.09673287,-0.00538245,0.061943065,-0.06936309,-0.04769053,-0.02224842,-0.02987571,0.027425494,0.19533779,0.00038016363 +1.14.14.31,"A cytochrome P-450 heme-thiolate protein. Involved in the insect aggregation pheromone production. Isolated from the pine engraver beetle, Ips pini. A small amount of (S)-ipsdienol is also formed. In vitro it also hydroxylated (+)- and (-)-alpha-pinene, 3-carene, and (+)-limonene, but not alpha-phellandrene, (-)-beta-pinene, gamma-terpinene, or terpinolene.",384,1.0,-0.051671363,0.0069476883,-0.006931359,-0.0039608628,0.047322016,0.06298575,0.026965145,0.044994567,0.04129218,0.019312736,0.054039888,-0.00029570208,-0.06342144,0.025424592,-0.04901753,0.053171236,-0.051031783,-0.0032424459,0.012813832,-0.0526008,0.017058719,0.019594684,0.0023239497,0.011410405,-0.07087849,0.0021989236,0.0003138722,0.020050751,0.0025114121,-0.04882495,0.0056746807,0.040575698,0.056197967,0.004793669,-0.053725522,0.06618015,-0.058362175,-0.06571294,0.0949095,0.016938634,0.08688585,0.00040429085,-0.051192474,-0.05707949,-0.113211036,-0.038729474,-0.0013100369,0.0711838,0.052575603,-0.091460966,0.0033069835,-0.058131054,-0.01632404,0.06687817,0.0061026993,0.009141745,0.04299103,-0.10726548,-0.026412891,-0.008870694,0.017277785,0.08979244,-0.031084843,0.018350638,-0.0035725343,-0.026002496,-0.07428418,0.05698085,0.044924475,-0.04337858,-7.209233e-05,-0.033943955,-0.0543149,0.062470097,-0.012592098,0.08790671,-0.053898375,-0.010803922,0.04975388,-0.08483154,-0.07919993,0.0034888338,0.006286579,0.12780201,0.050070327,0.005420251,-0.04786968,0.109050974,-0.058918666,0.0042549614,0.013790448,0.008978404,-0.045794856,-0.026064781,-0.03576777,0.0033570982,0.036518604,-0.04420984,-0.041358456,0.045390137,-0.009939245,0.037869427,-0.028494112,-0.14966054,-0.10240961,0.022576574,-0.032063164,0.01297845,0.081370726,-0.026841467,-0.0577721,-0.08452186,0.03157609,-0.0013321841,-0.043334085,0.022174414,-0.044968933,-0.019095346,0.08015809,-0.07372567,-0.007116349,0.008428023,-0.0009110257,0.01779231,0.009133257,-0.017526343,-0.07868589,-4.5433187e-34,0.08321946,0.051717453,-0.026956514,0.019741414,-0.029942462,0.036678456,-0.050454993,0.014351706,-0.0115785785,0.008381692,-0.071404204,-0.063498534,-0.0017625224,-0.014203623,0.015668597,0.009217489,0.0048319967,0.07965404,0.119896814,-0.004226907,-0.08928378,-0.01957787,-0.06406181,-0.06118279,0.053378884,0.07805757,-0.0389356,-0.046830993,0.036409482,0.009048088,0.07870244,0.031538304,-0.041380927,-0.001239712,0.022602305,-0.020322572,-0.04076941,-0.07550236,-0.07062276,-0.007163114,0.03758331,-0.056809545,0.008331325,-0.036429714,0.024314234,0.0010657473,-0.16963044,0.011832374,0.0671347,0.013128424,0.026103731,0.00918573,0.12549077,0.022266356,-0.07604922,0.0006782172,0.019214228,-0.006760851,0.012925296,-0.013100311,0.044237833,0.081458285,-0.030165263,0.0002970801,0.05996265,0.055522222,-0.06141475,0.0037786355,-0.10318459,0.07133697,0.0072076367,-0.018646544,0.009919256,-0.06209972,0.037216514,0.020136723,-0.018305054,0.035936076,0.018413521,0.020934775,-0.054180317,-0.055604924,0.021199487,0.0002235905,0.005431026,0.024687877,0.079224184,0.006187982,0.034207653,0.09373351,0.017873866,-0.092359394,-0.06440388,0.019997744,-0.033291582,-6.1531097e-35,-0.05495847,-0.062453963,-0.022903787,-0.100846685,-0.0061468617,0.057752974,0.0017119179,0.0008895152,-0.03541558,-0.009789881,0.07868499,0.011402253,-0.006359416,-0.044487655,0.016843863,-0.0005729382,0.016477745,0.058397572,0.05118183,0.036306113,-0.012590397,0.0040751086,0.047960386,0.032419972,0.00796363,0.0094137695,0.10503601,0.07591269,0.04628649,-0.016378008,0.11913046,0.050440114,-0.027328711,-0.08957375,-0.040876158,0.03760477,0.024286374,-0.06378645,0.08891808,0.0658851,-0.059547495,0.015233,0.0442537,0.03540906,0.07590848,0.066271335,-0.04924284,-0.050625797,-0.009800169,0.01331962,0.060291443,0.038346577,-0.003485998,0.0045685354,-0.05864783,0.011314622,-0.035421465,0.017120117,0.0399395,-0.14888743,-0.061463468,-0.055332925,-0.042896457,0.075471364,-0.025848368,0.008552281,-0.035477847,0.064059794,0.02291477,-0.03876031,0.05683342,0.0422024,0.08391132,0.0939945,-0.013628,0.01452401,0.09517025,-0.056116734,0.052300412,-0.020214003,-0.020051667,0.020584593,-0.04979913,-0.046282057,0.0112830885,-0.059929833,-0.027879007,0.14035611,-0.020670628,-0.0378454,-0.006433895,0.10744483,-0.011238094,0.049523294,0.0710661,-4.1972886e-08,-0.006972793,-0.08114696,-0.007856248,-0.035328288,0.0256537,-0.018215736,0.021591509,-0.03514795,-0.011110648,-0.04252525,-0.0018515157,0.034781583,-0.028422711,-0.005690781,0.0568571,-0.01590365,-0.018424217,-0.0031196002,0.007851061,-0.028174752,-0.0065031485,0.061342053,-0.0144164525,0.010372412,-0.029874085,-0.06827126,0.063844904,-0.07667327,-0.024289519,-0.009982839,0.056296643,0.12619738,-0.026373144,0.041549962,0.04217131,0.08077689,-0.09230696,0.0040728436,0.0018778049,-0.037342012,-0.010516721,-0.029054679,-0.08376516,-0.043102663,0.042183667,-0.07274253,0.031827558,0.07786246,-0.0055661113,-0.04992398,-0.041453224,0.098177664,0.0111348955,-0.05826574,-0.05057923,-0.06542193,0.017441655,-0.069353215,-0.0036859217,-0.058369532,0.0314652,-0.080005296,0.12513869,0.035714418 +1.14.14.32,"A microsomal cytochrome P-450 (heme-thiolate) protein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and 3beta-hydroxyandrost-5-en-17-one, leading to sex hormone biosynthesis. The activity of this reaction is dependent on the allosteric interaction of the enzyme with cytochrome b5 without any transfer of electrons from the cytochrome [2,4]. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter [1].",384,1.0,-0.053172924,0.015372626,-0.055250987,-0.04332322,0.061451465,0.060597096,-0.053224962,0.005438974,-0.039170142,0.059860937,-0.030688612,0.031177176,-0.016283851,0.020928826,0.02545277,0.062221713,-0.015454473,-0.0042826333,0.021466186,-0.010742428,0.045370013,-0.04751346,-0.029881978,-0.02561466,0.028263386,-0.056549262,0.03383269,0.07925054,-0.11309529,0.019292396,-0.039955016,0.0076968996,0.017244235,-0.05911065,-0.034970164,0.098900266,-0.11395231,-0.062135153,0.10421166,0.0045266193,0.00351802,-0.032343373,-0.08154085,0.024385404,-0.021126032,-0.04502755,0.04161726,0.02810327,-0.007979975,-0.016507741,-0.01154668,-0.034876425,0.00581877,0.05611619,-0.048641056,-0.050726358,-0.059571806,-0.050923105,-0.03172128,-0.028972875,-0.11115521,0.020647902,-0.07804485,0.028449923,0.042161725,-0.024625301,-0.037738718,-0.012594479,-0.048445113,-0.073033586,0.012989004,-0.027927902,-0.010997915,0.035525795,-0.036618814,0.0438396,0.0008618329,0.010163913,0.009443466,-0.029335253,-0.036100578,-0.0129445,0.0012911988,0.12432921,0.06681108,-0.0027605642,-0.0051698084,0.09458338,-0.0422554,0.089555636,-0.0025752606,-0.03190468,-0.023765182,0.023266945,-0.014549742,0.016693475,-0.040241692,0.0070886305,-0.00316034,-0.007993265,0.021835394,0.031245857,-0.020554448,-0.061921455,-0.04227616,0.03863418,0.019527704,0.07872348,0.058327947,-0.014750678,-0.039371457,-0.022686124,-0.038121175,0.046616737,-0.008002855,0.08605693,0.08139956,-0.01714264,-0.028365817,-0.07079404,0.018893734,0.023881754,0.089791454,0.03000659,-0.053617824,0.006975914,-0.029191667,2.8099551e-33,0.062467314,-0.025933042,0.030406471,0.020601472,-0.0292661,0.15383528,-0.05358713,0.038881302,0.019101288,-0.013302615,-0.09956721,-0.021165784,0.049407084,-0.080667794,-0.04319491,-0.0116119785,0.023921276,-0.053762708,0.11442458,0.028748035,-0.034474555,0.050630502,-0.05852903,-0.025534438,-0.025559474,0.08259903,-0.005313957,0.057360128,-0.01914026,0.010462958,-0.09281103,-0.08281554,-0.013117603,0.0010385452,0.021057628,-0.056073252,-0.019144919,-0.04224463,0.019848863,0.019804088,0.014553536,-0.07317256,0.030831458,-0.08424376,0.052328687,-0.028318144,-0.06678278,0.036926046,0.024466546,0.05617771,0.037369333,-0.0013597563,0.0793058,0.02320854,-0.117356084,0.07645286,0.008936852,-0.026516357,-0.035521857,0.096404806,0.03615921,0.06503249,0.034733064,-0.00888129,0.012853156,0.032668095,-0.014957204,-0.078458674,-0.10284556,0.1270616,-0.05291349,0.0053120074,0.10790533,-0.035488084,0.046666555,0.033552073,0.033135235,0.062931165,0.05586465,-0.025953675,0.019746505,0.034015715,-0.007094299,0.047487326,-0.028523022,0.059272002,0.024098229,-0.07904146,0.0865292,0.06557458,0.02874563,-0.109671056,-0.012967347,0.008481507,0.032501355,-4.3305884e-33,0.050729565,-0.116599046,0.02188481,-0.100569636,-0.047396053,0.050557263,0.08221119,-0.049997456,0.0014055062,0.007327922,0.06928328,-0.10293689,-0.03848422,-0.039838362,0.013684992,-0.014448051,-0.05535494,0.06742833,-0.0115940645,0.00022550294,0.01697905,0.11022114,0.0017375788,0.08724487,0.06754365,-0.007301418,0.058091976,0.006004259,0.10165207,0.086007334,-0.05539414,0.014763588,-0.059312515,-0.057726644,0.060522325,0.07763631,-0.06505713,0.075586855,0.054203562,0.03040332,-0.04796309,0.026472302,-0.013324628,0.004112675,0.034329057,0.08865173,-0.10742822,0.013009289,-0.01965775,0.03502871,-0.0072303647,-0.00766731,-0.079643436,-0.046550438,-0.0043017594,-0.0074239178,0.00947246,-0.046597987,0.055817842,-0.08437682,-0.019229252,-0.054057416,-0.038887713,-0.014854611,-0.0011782579,0.010659178,-0.04278566,0.037291795,0.05940135,0.061519716,0.058640473,-0.027433667,0.028246082,0.041637205,0.0011686332,0.019130632,0.0063809976,-0.07703491,0.030798854,0.021611072,0.041840456,0.05601506,-0.050804853,-0.022667032,-0.07918529,-0.08717325,0.005149393,0.11600705,0.0058272397,-0.019914024,-0.009407435,0.070981406,-0.03985674,0.014791617,-0.01170879,-4.7799865e-08,-0.0008299451,-0.013399783,0.015640365,0.00744809,-0.021693122,-0.0363227,0.0052895118,-0.052135628,0.11293509,-0.0648371,-0.017831974,0.10888749,-0.0073632505,-0.027260017,-0.026678406,-0.00427717,-0.027019942,0.019435555,0.02115557,0.043439798,-0.051458254,0.0068777115,-0.1236709,-0.017469577,0.011996177,-0.118687674,-0.017377565,0.028279416,0.06278135,-0.049686328,0.040995646,-0.019905014,0.009681037,-0.011907268,-0.01959311,0.044655,-0.045462493,0.0061178827,0.06463827,-0.010851754,-0.022855403,-0.09708304,-0.008700365,0.029048633,-0.024963412,-0.07223416,0.025544133,0.032317564,0.00011196127,0.009720927,-0.048057865,0.028607955,0.04389278,-0.09680101,0.0021343937,-0.029382333,-0.011745686,-0.10798252,-0.008151625,-0.059959676,0.0141556235,-0.01018171,0.15333474,-0.019858446 +1.14.21.12,"A cytochrome P-450 heme-thiolate enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine. cf. EC 1.14.21.2, (S)-cheilanthifoline synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline.",384,1.0,-0.06924625,-0.031512756,-0.089088485,-0.015616895,0.0479522,0.101646155,-0.05532317,0.0779263,0.019352386,-0.004352065,-0.043417264,-0.009491404,0.020811202,-0.034286,-0.08912992,0.08964967,-0.1256111,0.050247137,-0.014591945,-0.01953933,-0.03008885,0.027157383,0.041233398,0.03445394,0.006967192,0.019846376,0.023575293,0.05065223,-0.013590384,0.017478932,0.011334506,0.019378286,0.0048725056,-0.009153235,0.03229345,0.025632238,-0.0058456203,0.007854343,0.003529531,0.046943337,0.027406923,0.008301682,-0.09915525,0.03037013,-0.052170448,-0.039937466,-0.036156945,-0.004611981,-0.048627663,-0.03761731,-0.06307798,-0.020559352,-0.078547135,0.043348346,-0.031330623,0.037173264,0.016475005,-0.043046776,-0.018269101,0.0047004987,0.060628653,-0.04799448,-0.0010829119,-0.016866773,0.041355297,-0.05092452,-0.015917147,-0.024800204,-0.0017536428,-0.07657342,-0.051562138,-0.06735348,-0.023926944,0.050438218,-0.06625958,0.028094145,-0.004932681,0.0012872176,0.0063558025,-0.014823384,0.015964933,-0.012960096,-0.09201985,0.09436351,0.06292771,0.03591241,-0.0032377958,0.060671836,0.07115244,0.015087072,-0.0019419619,0.024728218,-0.049429085,-0.029104095,-0.15583462,-0.021550369,0.04646111,0.07572886,0.0002439923,-0.021390064,0.059234522,0.04290072,-0.03824785,-0.09719052,-0.017204342,0.050052047,0.009117009,0.05459934,-0.013416691,-0.0042220145,0.022829687,-0.08156967,0.026759498,0.012477164,0.0055291187,0.09681024,-0.023778012,-0.035462957,0.013760191,0.008559813,-0.03479298,0.003622418,0.023960512,0.0250247,-0.049848765,0.0042777816,-0.05066767,4.242534e-33,0.07440355,0.10998585,0.00771533,0.04091393,0.03424233,-0.014097582,-0.14563365,0.07411869,-0.05815486,-0.016829787,-0.10207073,-0.018039823,0.0104779275,-0.05396571,0.0030635563,-0.050229754,-0.11140768,-0.023407346,0.018812612,-0.03865955,-0.048280496,-0.019424574,-0.045857344,0.007048766,-0.005360299,-0.00381877,0.027837742,0.001208949,0.004904043,0.008540519,-0.036259502,-0.112458535,-0.020942388,-0.0662618,-0.067883894,0.0013869951,-0.008327486,-0.024444392,-0.029394915,0.077382766,-0.051335607,-0.019291146,0.029201545,-0.018203564,0.056550354,-0.048001368,-0.09738744,0.097428136,0.05720715,0.037606217,-0.01981659,-0.07746611,0.09830652,0.03600119,-0.10620148,0.049114868,-0.036370672,-0.056123104,0.027227502,0.06493617,0.057914644,0.015091279,-0.007180244,0.009536359,0.051966008,0.059878834,-0.009315256,-0.033325717,0.013624199,0.050151635,-0.08177703,0.020942902,0.087238304,0.051571846,0.008195328,-0.015273121,-0.031931948,0.06359591,0.08411194,0.02446622,0.030220916,0.023905542,-0.05068204,0.05963197,0.027604071,-0.036310364,-0.013920188,-0.0509551,-0.039841596,0.07430603,-0.010728172,-0.1329374,-0.010317239,-0.00508337,-0.0032574972,-3.7013757e-33,0.060630288,-0.07700175,-0.006522131,-0.0865383,0.014831861,0.026306873,-0.03159564,-0.002435529,-0.024605658,0.010933546,0.111498415,-0.013571014,0.06467549,-0.059037328,-0.015055916,-0.10133877,0.06566747,0.02746313,0.009945889,-0.0028770985,0.03940774,0.011207501,-0.0635521,0.022892226,0.01937025,0.054006256,0.023553059,0.018687736,0.05936336,0.075926,0.03534829,-0.017506931,-0.054555506,-0.046681345,-0.006015354,0.13813329,0.022575587,0.07462785,0.0519121,0.05595615,-0.030575909,0.007930304,0.0357764,0.036201075,0.06877215,0.061062608,-0.12796594,-0.009489061,-0.0039346623,-0.07211526,0.06594689,0.060902968,-0.07794706,-0.00031724366,0.021831052,0.0702361,-0.005566431,-0.030354688,-0.051982917,-0.054521948,0.010124731,-0.017031217,0.011822667,-0.007527674,-0.007900823,0.052762825,-0.09188363,0.056979094,0.11139652,-0.0058868066,-0.017192665,0.0073131113,0.021639783,0.060131263,-0.007529852,-0.016709296,-0.007354012,-0.019009814,0.04615805,0.019681288,0.010357294,-0.03357079,0.033662863,-0.049957644,-0.013196212,-0.059245672,-0.037056632,0.100038856,0.062187817,-0.041799925,0.006230953,0.038244214,-0.097310014,0.07380405,0.015044317,-4.58273e-08,0.024826868,-0.06475639,0.06385586,0.026104117,0.022779927,0.020982005,0.04900657,-0.06259318,0.08897583,-0.073608845,-0.00019201057,0.04958456,-0.022975722,-0.0040739835,0.03333125,0.028466918,-0.0466844,0.011495104,-0.010590426,0.0029400839,-0.042651754,0.04563218,-0.064948834,-0.010890726,0.010877916,-0.061151132,-0.0444782,0.013651465,0.028394977,0.04036032,0.073505014,0.024368672,-0.03340224,0.04430128,0.02677455,0.0047808406,-0.034064822,-0.026733903,-0.02358573,-0.049461566,0.029950498,-0.024489673,-0.09249168,0.050438307,0.09060321,0.018675556,0.035281725,0.06901187,-0.024360033,0.021662297,0.0048323744,0.021432703,0.032323193,-0.09739467,-0.12383184,0.031188257,0.021721816,-0.050216496,-0.07784508,-0.10891599,0.030271247,0.029808894,0.22258538,0.023598632 +1.17.8.1,"This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 4.2.3.156, hydroxysqualene synthase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.",384,1.0,-0.050256327,-0.024015667,-0.0324816,-0.006255349,0.060168806,0.022738965,-0.14566046,0.041974057,0.010711228,0.01973747,-0.008734766,-0.08675889,-0.016378604,0.033503883,-0.040713545,0.0005969656,-0.05456925,0.03779038,0.05702207,-0.0085517205,0.12911654,0.042246945,-0.0032174697,0.0038060122,0.03562078,-0.021354029,0.10013119,-0.06576591,0.0013542622,-0.05637092,0.011982458,-0.06925292,0.074091986,-0.07775524,-0.0050299615,0.08874507,0.021121815,-0.095848605,0.07534877,0.05052087,0.017680228,-0.020810286,0.041628547,-0.054305002,-0.0098305885,0.056687392,0.050482187,0.047341604,0.007563498,-0.09853264,-0.052907076,-0.07825279,-0.04999149,-0.0027907812,-0.013827749,0.0072922953,-0.04095999,0.00942919,0.018614106,0.024048423,0.07963419,-0.0065807076,0.032940444,-0.07200601,-0.017220648,-0.060698237,0.042460732,-0.023379479,0.02928347,0.0119214235,-0.12859221,-0.0068979426,0.0075192577,0.053051528,0.0061299438,0.013697814,0.0047989283,-0.042221118,0.039262217,-0.027257979,0.018303951,-0.06134632,-0.04990076,-0.013800386,0.0271463,-0.011484107,0.045702986,0.043773666,0.053972796,0.00052996574,0.034120273,-0.01857031,0.046706725,-0.008728479,-0.08967398,0.048932,-0.0025220208,0.14292681,0.06124043,-0.07629419,0.08717114,-0.009176842,-0.0019005865,-0.11080785,-0.010170857,-0.038489163,0.061530583,0.05232246,0.0025264737,0.010702667,-0.027790254,0.014739296,0.029154787,-0.006293346,-0.053121027,0.083514094,-0.021469355,-0.08905414,-0.0808409,0.0295144,-0.024537545,-0.0004818025,0.010606337,0.10309109,0.007268404,0.024949247,-0.1401468,3.6602782e-33,0.041598327,0.06710558,0.039931394,-0.025258165,-0.031095028,0.042012386,-0.09090987,0.013388268,-0.045361027,-0.03659812,-0.049120296,-0.0067744832,0.03323701,0.0048648054,-0.02474024,-0.0863021,0.015174808,0.010215088,0.08299056,-0.02638652,-0.024336984,-0.047263138,-0.08753919,0.03305394,0.056683414,0.022619098,0.030522997,-0.06213711,0.06443222,-0.030676102,-0.0141089205,-0.1116376,-0.0676428,0.023842743,0.043068934,-0.08145971,-0.009668019,-0.07852123,-0.016495027,-0.064620495,-0.014560421,0.012003632,-0.021020273,-0.025868056,0.06741955,-0.038267426,-0.05614427,0.06409406,0.07933576,0.005755571,-0.034213297,-0.026318323,0.081759,0.010604577,-0.047024902,-0.049488693,-0.055948928,-0.027422035,0.0649646,0.040974468,-0.018712644,0.06965798,-0.058754027,0.012476592,-0.0101515725,0.05792061,0.00043625094,-0.059070628,0.008604796,0.07176171,-0.054221317,-0.055701204,0.034649402,0.023864666,0.020152109,-0.031104628,-0.075610235,0.016628286,0.038759686,-0.012364589,-0.025574617,-0.004726597,-0.029870348,-0.031624183,0.0042072525,-0.009840694,-0.040734172,-0.01298595,0.03284511,0.0990186,0.061399344,-0.15209882,-0.06227489,0.05948869,-0.047705505,-2.839484e-33,0.09173603,-0.022737145,-0.04377769,-0.06397595,0.016096568,0.044053454,0.049130242,-0.015556337,-0.006197523,-0.055492133,0.09369566,-0.05333067,0.089911185,-0.06201425,0.002701451,0.008318593,0.07181387,-0.0059126834,0.02104849,-0.016719688,0.011650033,0.021736525,0.045924537,0.04153399,-0.0032714654,0.011121571,0.056743786,0.1200158,-0.0021370181,0.08920517,-0.0038311752,-0.0055922973,-0.06528769,-0.038711205,-0.047934644,-0.01236813,-0.0355008,0.0424454,0.055416297,0.008559221,0.031029921,0.0131896725,-0.052936424,0.074574634,0.028082587,0.10187757,0.0074834237,0.016698748,0.012326864,-0.09317926,0.031053534,0.026442701,0.05947506,0.0024996304,0.008518235,-0.03498105,-0.044388343,0.046399675,0.014878489,-0.025703076,-0.04628171,-0.083103254,0.042048775,-0.07159205,0.03432231,0.064078294,-0.029297901,0.10228715,-0.0026412797,0.03648689,0.07248077,0.01956014,0.0132252285,0.005651694,-0.06906714,0.022043943,-0.0025964149,-0.063127816,0.0009789411,-0.01826651,0.073222004,-0.014964077,0.042305153,-0.064900674,0.0043633436,-0.045816667,0.06610781,0.073552445,0.0019501179,0.06723242,-0.0564279,-0.033478018,-0.038845394,0.06841883,0.11376122,-3.873355e-08,-0.009245937,-0.04901085,0.06923815,-0.0077937795,0.021283843,0.049289532,0.01467528,0.04025058,0.015963545,0.010173089,-0.032097414,0.0079224,0.054646946,0.02418234,0.082235254,0.03184637,-0.060421646,0.07404576,0.025451288,0.036504366,0.02833846,-0.04725797,-0.13947241,0.048407968,0.008607195,-0.023006583,0.0760811,-0.03687949,-0.014985425,-0.07697692,0.032732457,0.027127411,0.015072269,0.039401866,-0.09574231,-0.017643837,-0.08704371,0.03159317,-0.053587135,0.03347174,-0.0030001937,0.022409001,-0.108235665,0.04152947,-0.0008453819,0.025092782,0.014847414,-0.006708813,0.038802642,-0.04179807,0.052960783,-0.008721772,0.039190743,-0.04855536,-0.037171796,-0.034350738,-0.060820196,-0.023186816,-0.049978394,0.013174831,0.02171684,0.009839153,0.17056371,-0.002243794 +2.1.1.327,"The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. The enzyme is active in vitro only in the presence of EC 1.14.13.218, 5-methylphenazine-1-carboxylate 1-monooxygenase.",384,0.99999994,-0.091782324,-0.0074803666,-0.12264995,0.06245893,0.036366627,0.04328658,-0.043967035,0.09714954,-0.021208404,-0.016739177,0.027074456,-0.05033329,-0.034417212,0.07283877,-0.10746931,0.022444343,-0.086885504,0.0040662787,0.03103628,0.05352452,0.032085184,0.071227714,-0.0073992945,0.06121655,0.00809192,-0.013137816,0.06784959,0.0393225,-0.01473778,-0.023054626,-0.021814816,-0.09793697,0.10570545,-0.0047802753,0.07463061,0.084520906,-0.029026905,-0.049114875,0.06843373,-0.0333644,0.028622927,0.011794065,-0.05314142,-0.088084504,0.007612728,-0.0051075947,0.01181237,0.022597397,0.065256394,-0.022466965,-0.05538644,-0.021532476,0.017526727,0.02802216,0.019693753,-0.03399676,-0.044296853,-0.045629885,-0.048723444,0.010418252,0.016580049,-0.02548324,-0.014549887,0.053604774,-0.012763985,-0.032357473,-0.0011556089,-0.040211797,0.01065295,-0.05394326,-0.01824314,-0.07736778,0.04168531,-0.024038818,-0.054624394,0.020751502,-0.0016644836,-0.037387323,-0.027170146,-0.00881757,0.07763636,-0.05257588,0.0052743475,0.0453612,0.022087602,-0.031070283,0.02604771,0.038699728,0.039559133,0.07015804,0.038477946,0.0010421284,0.04271883,-0.022192039,-0.06221905,0.020472813,0.0468666,0.050438713,0.025266595,-0.007001454,-0.006705789,0.038150787,0.00066892937,-0.06139604,0.0060556885,0.029955033,0.032804005,0.0076161544,0.064441614,0.022122558,-0.031564094,-0.02340362,-0.035199713,-0.055699237,-0.010151334,0.0965979,0.040783726,-0.02611273,-0.06317131,0.07009367,-0.021878967,-0.051621813,0.029899344,0.04538971,-0.040947244,-0.015490098,-0.12136127,2.245667e-34,0.04979236,0.023530612,-0.041609585,-0.061611623,0.033175137,0.030804235,-0.037048854,0.013489745,0.015887257,-0.08109961,-0.098204926,-0.068811245,0.059440985,0.022008574,-0.05161673,-0.033606328,-0.058459826,-0.043415803,0.0934823,0.01982428,0.024381263,-0.065167576,-0.12166518,0.00770506,0.0018574789,0.03940038,0.030799361,0.058009233,-0.024600467,-0.00554473,-0.0031136808,-0.060251497,-0.12480837,-0.030199327,0.100013085,-0.04311101,-0.01784238,-0.017532224,0.0066302274,0.029560301,-0.0069965925,-0.053654622,-0.030330265,-0.040472675,0.06464136,-0.040448017,-0.07847221,0.15477972,0.0403982,0.09631358,0.052061386,-0.048010625,0.06214276,-0.0059512174,-0.036876254,0.02691721,0.0018004307,-0.062058643,0.063125975,0.007814308,0.078542136,0.012040054,-0.05182985,0.010710924,-0.02651816,0.04313356,-0.0387921,-0.056215756,0.02705847,0.0046935515,-0.060788773,-0.058727056,-0.01167649,0.028828084,-0.0130050825,0.001484373,-0.043154765,0.04075116,0.033874534,0.04760139,-0.03188918,0.011193289,0.016759042,-0.009534542,-0.04176346,0.029043796,-0.00021479564,-0.017308677,-0.025729433,-0.023636498,0.10813306,-0.14349309,-0.035879474,0.060201164,-0.028960181,-1.6670975e-33,0.065869525,-0.0442913,0.05044566,-0.09002384,-0.00707072,0.055879667,-0.010176789,0.047469832,0.0056905183,0.036558487,0.05256912,-0.055460237,0.0418214,-0.0165468,0.050978724,0.05559386,0.01603799,0.04525911,-0.031925708,0.0013094464,0.00935176,0.031494062,-0.046117645,0.023066375,0.007213728,0.03277664,-0.032077454,0.06879118,0.040554486,0.115697995,-0.08810302,0.050351158,-0.058749616,0.0191384,0.02110504,0.0767152,-0.033738926,-0.023424046,0.072902344,-0.016194701,0.037533406,0.024942484,-0.054402526,0.11619876,0.01797904,0.07845469,-0.035584256,-0.023826359,-0.0033152106,-0.103363164,-0.0130196875,0.10952473,0.06710093,0.036983304,-0.015438627,-0.011055735,-0.02078527,0.007484687,-0.0060002813,-0.029597169,0.031961437,-0.13557135,0.011070397,0.011145939,-0.0015020006,0.030908303,-0.02838267,0.023558458,0.035625212,-0.044664018,0.0783339,0.009037842,0.039995436,0.047621816,-0.13072953,0.016464328,-0.018079147,-0.087137744,0.0039832066,0.016494194,0.101022534,-0.003922491,-0.0034150833,-0.07919428,-0.039411746,-0.06635504,0.070045196,0.04870629,-0.056164164,0.006009987,0.0028982577,0.04729587,-0.02475636,0.059015136,0.051876064,-3.7275914e-08,0.02630848,-0.07581077,0.08468998,-0.03189438,0.057213694,0.055717148,-0.042810984,-0.021433258,0.028352853,-0.06387936,-0.032909796,0.05018368,-0.06325216,0.043612424,0.029431975,0.017362734,-0.07211481,0.0628263,0.01735776,0.03193336,-0.03676899,-0.010154544,-0.10588631,-0.00601655,-0.00048024824,-0.0293988,0.005827542,0.020563297,-0.010977436,-0.021179268,-0.01646508,0.02246607,-0.02199323,-0.023620192,-0.14013249,0.04404276,-0.028835502,-0.06771179,-0.11528861,-0.070090234,0.03581797,-0.016992096,-0.0363256,0.0085516935,0.000178962,0.02038285,0.0011834421,-0.022244018,-0.024119034,-0.06254155,0.12454471,-0.022310311,0.0030258656,-0.057370145,-0.08442934,0.010464652,0.0040945625,-0.03259305,-0.07462572,0.035844482,-0.034731124,0.063758485,0.19526687,0.01925685 +2.1.1.328,"The enzyme, characterized from the bacterium Streptomyces griseus, catalyses the ultimate reaction in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2).",384,1.0,-0.015376889,-0.0066119316,-0.15388522,-0.04628405,-0.044173162,0.042350806,-0.03244354,0.06587114,0.07698821,0.014739251,0.0309311,-0.013488597,-0.007936082,0.091363445,-0.070754215,0.0109240115,-0.051660206,-0.028232658,0.075133435,-0.056742076,0.054524083,0.1092425,0.0037554083,0.0016023566,0.028051775,-0.017422948,0.013049102,-0.036105007,-0.0469223,-0.035898007,0.0058445674,-0.02732831,0.04730559,-0.03781625,0.05468939,0.051808033,-0.06964434,-0.014388779,0.16098523,-0.019475926,-0.0691532,-0.058151137,-0.052361622,0.007776722,-0.004240157,0.023769429,0.055562597,0.082571834,0.015701829,-0.03171463,-0.026045956,-0.037342317,-0.06285249,0.053396277,0.11541314,0.04268403,-0.02245771,-0.02381963,-0.0062335636,-0.029439062,0.06796279,0.011413143,0.005285928,-0.0065704864,-0.04989755,-0.090365484,0.031827137,-0.083667725,0.06604328,0.012080789,-0.059994757,-0.07858077,-0.01729109,0.074611135,-0.020540632,0.017830908,-0.03564841,-0.025301099,-0.039980505,-0.02564446,0.06265608,-0.037807655,0.027248228,0.10835624,0.042037904,0.00993781,0.041628446,0.03231882,0.08649909,0.010939433,0.064397156,-0.025417063,0.006952233,-0.06474539,-0.059204377,0.026551994,-0.0774528,-0.06103552,0.03846401,-0.015470721,-0.008878734,-0.00658641,-0.023135487,-0.06329818,-0.022149568,-0.031461988,0.018389577,0.067530744,0.0450353,-0.034676448,-0.04482134,-0.020773012,0.015070424,0.012385955,-0.06112614,0.059862453,0.12625068,-0.030778889,-0.053781815,-0.00475058,-0.0018968019,0.08214929,0.008228501,0.08087281,-0.037649278,0.026682781,-0.09243249,-5.6977267e-34,0.027455691,0.0199428,0.0015210107,-0.06544512,0.051903423,-0.006202312,-0.08243245,-0.006454122,-0.023853013,-0.026208092,-0.087061316,-0.0959823,0.031050885,0.027570529,0.05707243,0.030976027,-0.10430286,0.036960818,0.04092487,0.00081102276,-0.030854246,0.014549461,-0.0055082175,0.012780187,0.03855445,0.056827515,0.01326652,0.052165426,0.09616562,-0.04266849,-0.023355588,-0.052077733,-0.07114738,-0.013111572,0.035256926,-0.064242765,-0.04424825,-0.03083331,0.0019705126,0.0736893,-0.04421606,0.05315603,-0.0050094146,0.0010014563,0.05506984,0.00076517713,-0.02799597,0.11269442,0.045605924,0.05488768,0.07519602,-0.07202143,0.034709636,0.004174857,-0.08314277,0.028581563,0.00039356895,0.019634698,0.0424121,0.015575356,-0.036356878,-0.032118045,0.012891306,-0.005342486,-0.020037226,3.525174e-06,-0.04524144,-0.061781872,-0.0028014644,0.054345828,-0.10655075,-0.0102413455,0.074881844,-0.015506152,0.0070555275,-0.013702422,-0.035511874,-0.04824992,0.06077422,0.022724302,-0.038689524,0.00042855577,0.033655982,-0.04992825,0.034540486,-0.0033412005,-0.08578119,-0.081813,-0.02169811,0.040294576,-0.0060887127,-0.019297723,-0.11374565,0.06777349,0.01613232,-1.2486657e-33,0.08584266,-0.104021214,0.03891042,-0.041656923,-0.011915536,0.063553706,-0.068673275,-0.08980584,0.018456215,-0.047733076,0.08515168,-0.041431874,0.068463065,0.02217228,0.036475673,-0.095374756,0.014673535,0.05178975,-0.04586783,-0.0100147,0.038639978,0.042651728,-0.030574875,-0.046997875,0.054537144,0.019492576,-0.015765361,0.0646171,-0.0086700935,0.07119693,0.04850288,-0.08560586,-0.07723853,-0.00050639454,0.00056300306,0.1400762,-0.017197395,0.04891521,0.06288363,-0.025644446,0.06381273,0.025703544,0.025586363,0.053337656,0.0122945765,0.035049383,-0.036300927,0.06463879,-0.015862316,-0.07635855,0.024924833,0.033775393,0.011147953,-0.0503393,0.025385583,0.008475169,0.0024230126,-0.037637264,-0.0018791006,-0.022027409,-0.04592473,-0.05912995,0.056503844,0.0068202843,0.020507822,0.053712443,-0.004677914,0.09234869,0.08415796,-0.0495319,0.07524886,0.010459194,-0.044441923,0.075174,-0.038326733,-0.048916858,-0.055856396,-0.05830447,0.042250004,0.027796987,-0.016332522,0.022438824,-0.015323835,-0.016835695,0.0035404854,-0.05694649,0.0150275715,0.09906804,0.04704184,0.050769325,-0.008414546,0.045111228,0.0241941,0.010861515,0.042640634,-3.376085e-08,0.042915262,-0.076568745,0.0032781914,-0.048447683,0.034605537,0.0023329705,-0.043318298,-0.008312424,0.041863866,-0.08202749,0.00011299247,0.046271935,-0.04153548,0.030419558,0.014242393,0.019015048,-0.060816936,0.008409847,-0.012013874,-0.053123627,-0.10049903,-0.00569265,-0.1284692,0.017732104,0.0240372,-0.07791986,0.027034229,0.017197711,-0.03900161,-0.019052474,0.020096567,0.0078388,-0.030458204,0.021549273,-0.06437164,0.013737888,-0.031764366,-0.0019084455,0.013701871,0.016982699,0.047880255,-0.007816447,-0.072831415,0.012827786,-0.0686986,0.04213419,0.008377947,-0.018138453,-0.04969632,0.0072726477,0.092461556,0.04256804,0.022718824,0.007518818,-0.12122701,0.031315517,-0.02888668,-0.08047954,-0.0654471,-0.0409046,0.025419213,0.002311322,0.22286022,-0.020978877 +2.5.1.133,"The enzyme catalyses the addition of a geranylgeranyl hydrophobic chain to bacteriochlorophyllide a via an ester bond with the 17-propionate residue. The side chain is later modified to a phytyl chain, resulting in bacteriochlorophyll a.",384,1.0,-0.059867565,0.030937541,-0.017496958,-0.018872913,0.07604002,0.053625736,-0.027951567,0.0058133826,0.050389178,-0.009716558,0.09655636,-0.047663204,-0.03756614,0.086829245,0.0018024793,0.0810922,-0.14477958,0.083674744,-0.049877338,-0.07807991,0.013726542,0.038847063,-0.06857873,0.039846275,0.018554011,-0.028158741,0.035333477,0.038456816,0.010545573,-0.023174018,-0.026188891,-0.0015072175,0.041609205,-0.038005535,0.014068447,0.02943501,0.021663118,-0.07479846,0.106941365,0.032674972,-0.0080222385,0.055405896,-0.01677682,-0.027928116,-0.09877517,0.001760468,0.016178137,0.039820086,0.007232096,-0.039560873,-0.05944134,0.01077785,-0.047604408,-0.06877501,-0.014321904,-0.039766468,-0.0033402513,-0.09247465,0.02080301,0.010356044,0.032392945,0.0062179193,-0.016668124,0.021305438,-0.03074718,-0.10207203,0.038649425,-0.013056277,0.060148884,0.0035805486,-0.060697924,-0.0818038,-0.052097812,0.033767097,0.019906996,-0.041564886,-0.017546626,0.018602777,0.033639744,-0.005220964,-0.007915135,-0.035682723,-0.02495556,0.08327314,0.056136787,-0.03337382,-0.014311108,0.0426643,0.07975614,0.015119402,0.02876377,-0.07985169,0.0065963934,-0.05622866,-0.08716674,0.07055259,-0.048891034,-0.11278436,-0.0011100763,0.046686452,-0.004417373,0.004884897,-0.019055676,-0.064375356,-0.00024204949,-0.002771807,0.00512658,0.06602066,0.0065149944,-0.0063833883,0.05737937,-0.009850232,0.07541603,-0.02723337,-0.06826524,0.029461237,0.027996305,-0.004918904,-0.049413692,0.008806155,0.07249264,-0.045993313,-0.009488484,0.03481654,-0.07119225,0.0020261912,-0.13398622,4.5534857e-33,0.09788435,-0.025524111,0.018466067,0.01697172,0.0051367725,-0.009897337,-0.054767583,0.026171336,-0.06693155,-0.05583992,-0.047416676,-0.104471825,-0.01118171,0.0114784045,-0.06937933,-0.016963694,-0.02796135,0.041976426,0.023895467,0.019142995,-0.007701204,0.06655541,-0.009087211,0.02757568,0.079839595,0.025612567,-0.019878186,-0.0066526425,0.09494272,0.007588265,0.02471759,-0.06278242,-0.102071345,0.044773486,0.01368738,-0.014831601,-0.03179068,-0.078063585,0.060349043,0.049373027,-0.04244023,0.052286975,-0.025881527,0.003439405,0.053305883,0.07605826,0.010439892,0.09885346,0.036627997,0.09005689,-0.015908891,0.0116828615,-0.007108552,-0.032966003,-0.08373151,0.008130789,-0.012600933,0.0070558717,0.00086363615,0.050401956,0.009973082,0.085850514,-0.028194228,0.0023168637,0.030699868,0.006096446,0.013839127,-0.059260868,0.05822829,0.041720152,-0.102719694,0.0053969077,0.049537174,0.09310699,0.016527323,-0.05706715,-0.06404298,-0.09777923,0.07597164,0.00026873348,-0.061046842,0.010583268,0.047833618,-0.026294816,-0.08021256,-0.013930711,-0.0771899,-0.051851418,0.010557932,-0.012573419,0.036543656,-0.06272529,0.006894196,0.07137646,0.029345717,-5.5992697e-33,0.08037348,-0.12754981,0.026657457,-0.06914932,-0.07792493,-0.027451176,0.008627525,-0.05959222,-0.045065112,-0.0013072483,0.06836046,0.011667024,-0.021769421,0.032069437,0.010798903,0.0027920143,0.1012261,0.09969284,-0.036671195,0.0016828333,0.007289246,0.041689456,0.048928116,0.021508126,0.019382281,0.022571784,-0.0017794212,0.017615233,0.05837883,0.032365892,-0.029146677,-0.047145583,-0.038591407,-0.054081753,-0.0066827955,0.074708834,-0.011131736,0.02534281,-0.010902137,-0.020426234,0.01395461,-0.0024770894,0.005725588,0.037153684,0.011433026,0.062568344,-0.04584824,0.03017721,0.07788169,-0.09966705,-0.041033816,0.04259573,-0.006445535,-0.017959194,-0.03531278,0.036396585,0.06267591,-0.030355996,0.014044243,-0.018752946,-0.037322186,-0.04277141,0.008939477,-0.02833028,-0.019499047,0.103820145,0.009315809,0.047459286,0.085263595,-0.1003974,0.03495246,0.05783993,0.063569985,0.0033227997,-0.02936007,-0.014641388,-0.0011926128,-0.16052006,-0.026093826,-0.022349004,0.006570064,-0.007458541,-0.060710195,-0.027125893,-0.01096323,-0.07283005,0.019146292,0.08319549,-0.0256773,0.009001587,0.022262108,0.06521121,0.025728177,0.049114034,0.07051197,-3.5151775e-08,-0.02345075,-0.06539631,0.010703494,-0.08779249,-0.01715678,0.081944585,-0.03029197,-0.015162718,0.05623324,-0.042536255,0.0002409312,0.09316448,-0.036755305,0.052422382,0.028242117,0.029677344,-0.07060896,-0.028580422,-0.023306103,-0.055664767,-0.07547647,-0.01082756,-0.13475554,0.053725388,-0.023468753,-0.050459877,0.01755446,0.061427776,0.013967087,-0.0009906412,0.012673299,-0.011324394,-0.07234663,0.090160504,0.026692113,0.009495192,-0.077298425,-0.03866633,0.002552904,0.030293185,0.06637508,-0.0059620095,-0.103211045,0.04363616,0.0649478,0.019721407,-0.045825135,-0.0051281243,-0.05616758,0.05444087,0.15926282,-0.035123367,0.05640689,0.022542622,-0.061026365,-0.04079754,0.00760331,-0.08929657,-0.049335174,0.022145728,0.045850717,-0.035758324,0.17114113,0.01311558 +2.5.1.134,"A pyridoxal 5'-phosphate protein. The enzyme, purified from the bacterium Bacillus subtilis, also has a low activity with L-serine (cf. EC 4.2.1.22, cystathionine beta-synthase).",384,0.99999994,-0.053113382,-0.061085157,-0.040338248,-0.057361856,0.04874591,0.0416682,-0.055567138,0.05620974,0.053250805,-0.010552436,0.029238548,-0.023409368,0.0039023738,0.10827382,-0.04605719,0.03220734,-0.074426636,0.014683089,0.025080072,-0.042097908,0.10800639,0.0819978,0.010187249,0.018512677,0.009455872,0.03892532,0.041793745,-0.0324111,-0.04001359,-0.022629648,-0.04089727,-0.0176346,0.04017134,-0.09418471,0.08489514,0.07061641,-0.045219645,-0.008471088,0.11263963,0.021516131,0.043552283,-0.037374884,-0.04573001,0.0073353443,-0.051864423,0.04594755,0.06763375,-0.005865145,0.036889084,-0.05306592,-0.09755591,-0.0195694,-0.030442802,-0.01588566,-0.014402802,-0.028733883,-0.039573938,-0.009584964,0.008858315,-0.029473519,0.015599201,0.0023977095,0.04723795,-0.03115949,0.051472746,-0.04105717,-0.00035456684,-0.102256216,-0.023485228,-0.01826137,-0.06349409,-0.037574396,0.07151319,0.06610177,-0.021221634,0.04132118,-0.056970216,-0.02252587,-0.020791978,-0.006829583,0.04956314,-0.03585816,-0.040546402,0.13277866,0.03911605,-0.017092053,0.036917046,0.016334394,0.019945178,-0.011213754,0.035914425,0.00045246488,-0.044217452,-0.02963012,-0.025019793,-0.0086999405,-0.040948354,0.003994394,-0.0281428,-0.020031061,-0.02289366,0.046371657,-0.009244772,-0.059112366,-0.073311016,-0.013637045,0.025565904,0.06873865,0.010222079,-0.014066426,-0.015048571,0.02483872,-0.014530904,-0.044035744,0.000838503,0.02301304,0.0520271,-0.0233003,-0.101606525,0.01178872,0.018749965,-0.031614307,0.040982418,0.10346374,-0.045105048,0.0592291,-0.14952114,6.7046616e-34,0.075137265,0.063332945,0.08329864,0.014372454,-0.011440738,-0.024366261,-0.06943095,-0.027765468,-0.028593542,-0.055669744,-0.046462633,-0.053573746,0.039502133,0.021967877,-0.034487564,-0.015548263,-0.024666732,0.015869029,0.09114041,-0.04448253,0.053104687,0.06149485,0.022937782,0.036409646,0.04566413,0.045367237,0.027735591,-0.017012373,0.01947588,-0.013501671,0.016717708,-0.10475404,-0.07006616,-0.054520532,0.07911279,-0.059685048,-0.07041734,-0.027022827,-0.042885937,0.04228821,-0.029376907,0.017684346,0.010022559,0.00084740523,0.022223447,-0.0737805,-0.048358943,0.08198888,-0.03273693,0.046733335,0.06496164,-0.05103083,0.049824618,-0.061594013,-0.08924703,-0.003972731,0.014770498,0.01751795,-0.008259398,0.054796018,0.07131182,0.03660323,-0.059375137,0.022640623,-0.009527235,0.02044057,-0.016402705,-0.04258663,0.05585164,0.04698561,-0.027833251,0.04713081,0.07019626,0.04363948,0.003004521,-0.008819508,-0.067347735,-0.02150441,-0.012819483,0.03314908,-0.013644336,-0.09474338,-0.028167574,-0.0047456753,-0.04569506,-0.012848335,0.0064483257,-0.050765403,-0.011090042,0.023628147,0.038195115,-0.18097764,-0.056104753,0.07493052,-0.033823214,-1.43780555e-33,0.11432826,-0.098574504,0.0897355,-0.07639394,-0.07812407,0.007497171,0.074375354,-0.012237813,0.026357915,0.039391607,0.053811233,0.0029539848,0.061547887,-0.0109704025,-0.0035113837,0.0467349,0.024048787,0.024191301,0.069849774,0.028413612,0.010637135,0.07385867,0.03054844,0.032256704,0.07867737,0.07765999,0.01407056,0.1276939,-0.028700387,-0.045793746,-0.01586333,0.042272087,0.015817093,-0.13641047,-0.098862804,0.05613063,-0.06346896,-0.028962515,0.052358188,-0.025010943,-0.004977115,0.09023266,0.027224947,0.024268154,0.01862839,0.040038746,0.014272546,-0.013739108,0.024295233,-0.044801358,-0.00016693395,-0.015823247,0.018215738,-0.046121787,0.0495925,0.008931261,-0.090206735,0.08427321,-0.014887114,-0.0100906575,0.009772706,-0.073372215,0.0140284635,0.07699052,0.026864372,0.10765109,0.012043702,0.022839606,0.050003745,-0.011315148,0.056728244,-0.0011611759,0.06910141,0.086160675,-0.04873218,0.0033790206,-0.056781903,0.034007434,0.0343918,0.00096206943,-0.05014925,-0.046533674,-0.067447625,-0.08135876,0.030211292,-0.020016663,0.035789598,0.09014173,0.038429346,0.009813201,-0.049979918,0.0076173698,-0.0017719071,0.0369279,0.071691304,-3.791609e-08,0.09336803,-0.08364695,0.030696651,-0.038221326,0.0410983,0.0035369475,0.013149208,-0.026183657,0.0792168,-0.03176506,-0.020723414,-0.023168301,-0.026262797,-0.026118994,0.04376294,0.038284615,-0.04988469,-0.00049119926,-0.0040819645,-0.055331852,-0.058693055,0.01842055,-0.08533576,0.051061254,0.060409036,-0.08294396,0.019223908,-0.02306239,-0.03858892,-0.06495374,0.031971414,0.015446387,-0.002840599,-0.062456995,-0.058682896,0.063493416,-0.09612321,0.006487045,-0.0026601173,0.090555854,-0.01638589,-0.01638124,-0.06657824,-0.020916121,0.011797065,0.07940805,-0.07051934,0.015722089,-0.031426206,-0.0763165,0.06822462,-0.01777314,-0.058218826,-0.029867822,-0.1382362,0.09336994,0.022789294,-0.030259289,-0.021350695,-0.081876166,-0.022263505,-0.029655565,0.13399106,-0.051638022 +2.7.1.211,"This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.",384,0.99999994,-0.027721606,-0.024458535,-0.07146504,-0.011209316,0.0760534,0.0022852588,0.022834014,0.052764885,0.039395597,0.03333265,0.013931248,0.01711758,-0.05593691,0.063931495,0.02174347,0.0030614925,-0.037425958,0.011644958,0.032030474,-0.04525814,0.13427521,-0.0068776333,-0.01261132,0.008655343,0.04921779,-0.006871173,0.021861447,-0.010321045,-0.0028681927,-0.06917224,-0.060636725,-0.088135876,-0.015780224,-0.013326472,0.013625941,0.13798933,-0.04630141,-0.07778883,-0.017665287,-0.031547878,0.09133903,0.011908284,-0.02677738,-0.0035323827,-0.02501821,0.019517777,0.0052213054,0.03351472,0.0019339605,-0.04139912,-0.049978137,-0.045568522,-0.031765565,0.027337613,-0.013066892,0.1035248,-0.016912753,0.04867718,-0.027088469,-0.024071055,-0.043291952,0.018819686,0.04225472,0.022904634,0.070964105,-0.06294145,0.030061165,-0.080637164,-0.041319296,-0.047066238,-0.07011175,-0.054369662,0.057307553,0.0066747186,0.08090459,-0.0394766,-0.040610168,0.05982045,-0.014339132,-0.018546276,0.070944235,-0.00716714,-0.027159184,0.011657526,-0.040082134,-0.023436943,0.027585618,0.014404767,-0.010433163,-0.0017687352,0.013986093,-0.031192487,0.0673279,0.0114909755,-0.026689675,0.0016443878,0.00083404925,0.030734327,0.047050234,-0.024238292,0.030252656,0.09869585,0.02019551,-0.042752936,-0.0029494266,0.046762895,-0.080642134,0.0498427,0.048502933,0.030187428,0.044709194,0.079269394,0.067021355,0.01453898,0.018436523,0.08723278,-0.015284894,-0.031730093,0.016812544,0.032434154,0.018909201,-0.061910193,0.02584574,0.052081324,-0.085501194,0.072914235,-0.13772187,1.1680779e-33,-0.018029042,-0.012435278,0.008716466,-0.02699498,-0.019989755,-0.0061825803,-0.062025007,-0.024858003,-0.036896765,-0.05032654,-0.09364131,-0.07802825,0.023269134,0.060826592,-0.02035645,-0.043904226,-0.016293889,0.08030193,0.12187219,0.04201656,-0.012816927,0.01673107,-0.03152808,0.01766861,0.076973476,0.08654165,-0.048748106,-0.011398388,0.01932468,0.0038167324,0.036774673,-0.077291206,-0.0737902,0.026698891,0.039517667,-0.07925702,-0.018920654,-0.06434087,0.022685708,-0.020842895,-0.038625278,-0.02243484,0.019945152,-0.009222973,0.04415871,-0.123344354,-0.033087093,0.037447214,0.010451484,0.029994277,0.023741607,-0.0884904,0.111657836,-0.028674692,-0.043296065,-0.003189133,-0.003741365,-0.030877883,0.05699404,0.05076796,0.008905333,0.07612618,-0.0149794975,0.029622091,-0.023644513,0.022043303,-0.08199322,-0.07229842,-0.032559767,0.12594363,-0.047389653,-0.008932679,0.06919455,0.025572583,0.06194736,-0.092408545,-0.019893799,0.008146343,-0.014229572,0.039697282,-0.0018054175,-0.03188781,0.012966081,-0.03313748,-0.05464024,-0.04988307,-0.010726335,-0.08503043,-0.04766254,0.063798614,0.0073009627,-0.03307446,-0.07826353,0.029417157,0.018206676,-4.187992e-33,0.13952924,-0.05460118,0.080192514,-0.12595525,-0.05533219,0.04013668,0.041280836,-0.08100166,0.051325593,-0.0066009113,0.007770515,-0.012737053,0.04986636,-0.043760147,0.031962007,0.037623614,-0.044989817,0.09178916,0.025707427,-0.007964742,0.0060968376,0.12335354,0.02014155,0.07307456,0.051727373,-0.07378524,-0.044150993,0.09716697,-0.014587792,0.017797878,-0.031721894,-0.023799514,-0.036848895,-0.028589483,-0.070335805,0.011797412,-0.087913044,-0.05684232,0.0011442199,0.056451645,0.039534472,0.08458052,0.06339009,-0.022032842,-0.04308783,0.06756526,-0.036294192,0.038878657,-0.019028043,-0.05012814,-0.027199732,0.022993637,-0.04118689,0.051412374,0.02939113,0.07407058,-0.035066083,0.07016896,-0.03674581,-0.05715436,-0.010212681,-0.1324673,0.0053838645,-0.00027952966,0.039945923,0.005757275,-3.9644146e-05,-0.028215732,0.0046215914,0.04404051,0.027617786,0.017389711,0.008821929,0.05196341,-0.015489516,-3.9200622e-05,-0.11046688,0.0057313177,0.016648328,-0.09241398,-0.0009752216,0.0009724198,0.0035376537,-0.094840534,0.016526008,-0.038351983,0.03249815,0.10091862,-0.022481719,-0.0082677705,-0.023228237,-0.02467269,-0.04685664,-0.013657031,0.06447379,-5.163195e-08,0.04634252,-0.04960968,0.004171856,-0.06841268,-0.0042189434,0.0003797655,-0.021137804,-0.0010029913,0.019650703,-0.0069744303,-0.07382007,0.06596649,0.019076673,-0.041978482,0.04394742,0.06696062,-0.054661192,0.03803298,-0.01663941,-0.0070152995,-0.041831136,-0.04736157,-0.12094966,0.07775734,0.04139391,-0.0025368906,0.07651447,0.05323104,-0.030832585,-0.039730746,0.016198162,0.001850613,-0.05214755,-0.02940881,-0.04245046,0.03274278,-0.023508849,-0.013627438,-0.00045193685,0.030961685,0.00069603976,-0.072221294,-0.024966506,0.032106247,0.0024410002,0.11158272,0.007777583,0.035813585,-0.04819773,0.011615547,0.05462177,-0.052272476,-0.068857335,-0.07791984,-0.079422966,-0.009430806,-0.038168333,-0.039072134,0.03057824,-0.02391451,0.08498781,0.09640894,0.19896477,-0.108790115 +2.7.1.212,"The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in an archaeal pathway for nucleoside degradation.",384,1.0,-0.08078163,-0.012604491,-0.08625236,-0.015037291,0.08967825,0.024357377,-0.097385824,0.0024117501,0.04936521,-0.01719212,-0.032094613,-0.053387668,-0.054431845,0.06328917,-0.08034972,0.012815166,-0.12993847,0.04685442,0.06517887,0.00021925903,0.07485057,0.05386423,-0.019565376,0.0651065,0.015243202,-0.00872044,0.042096794,-0.028157577,-0.07041246,0.028862596,-0.030464305,-0.023351217,0.11063209,-0.021823833,0.10470182,0.12878822,-0.01664039,-0.041766178,0.051184624,-0.008019913,0.08425547,0.017347196,0.06286833,-0.0011319082,-0.038227294,0.06466927,-0.021416983,-0.012023035,0.05588043,0.033131268,-0.029845087,-0.064050645,-0.027176512,-0.015261837,0.050443016,0.11280992,-0.012713542,-0.082906015,0.0040620896,0.004095222,0.09163702,-0.02625156,-0.020611573,0.08746879,0.026639674,-0.050251864,0.07888799,0.011794692,0.011821606,-0.03792828,-0.054424323,-0.019703984,-0.037787337,0.03397984,0.0037764753,0.024849473,0.0068142377,-0.08328073,0.029883122,-0.031658627,0.05367724,0.014408294,0.00017304272,-0.008288789,0.040695496,-0.013849642,0.07986492,-0.041450914,0.09149274,0.013882644,0.008010138,0.01490902,0.010165072,-0.12715967,-0.018249555,-0.0064833183,0.008838645,0.030526612,-0.00012436043,-0.04489702,-0.020462688,0.03507886,-0.027087055,-0.11478858,0.016314637,-0.0010011652,0.004572397,0.042170055,0.07916549,0.101529054,0.04567768,-0.053288307,0.009619425,-0.01457709,0.050883166,0.048501007,-0.010817421,-0.052167814,-0.14448518,0.037010975,-0.087200694,-0.05812913,0.034699604,0.024095526,-0.13870215,0.060317144,-0.05206136,3.0505281e-34,0.04762948,-0.030166728,-0.027763769,-0.047791116,0.073356934,-0.044801507,-0.057077676,-0.03688979,-0.060616907,-0.0821976,-0.051344287,-0.032789197,0.036485717,-0.014252153,-0.015447713,0.057400357,0.003336543,0.052156825,-0.011915671,0.016256565,-0.041127607,0.092453025,0.027900346,0.016432244,0.08417601,0.025204936,-0.05057254,0.0001523601,0.005279204,-0.0334124,0.016857918,-0.099075235,-0.18191987,-0.0048520984,0.093686104,-0.008590433,-0.051445913,-0.030312032,-0.029656043,0.025664225,-0.008624751,0.017896231,0.018397031,-0.0054013515,0.018565299,0.009703402,0.017878488,0.108465776,-0.030289393,0.046519227,-0.027340082,-0.04025053,0.01212294,-0.010056982,-0.08172903,-0.020955006,0.012090233,-0.008497817,0.027973093,-0.01893628,-0.0128978565,0.056850787,0.014609255,0.053412806,0.0019075811,0.004810984,-0.07385943,0.019826924,0.051825512,0.022877533,-0.026210438,-0.034761682,-0.029267931,0.0012483487,0.009382768,0.0011257362,-0.082325295,-0.07330094,-0.023305867,-0.025126813,-0.040375344,-0.027511604,0.044629928,0.026776051,-0.025181098,0.0029602887,0.02498888,0.0092737395,-0.0073533645,0.041751605,0.069651365,-0.07932071,-0.030624758,0.06923519,-0.023727566,-1.8365955e-33,0.09864875,-0.10165242,0.015909433,-0.060298495,-0.114532806,0.02305879,-0.0020427252,-0.02120841,-0.020123377,-0.06351343,0.07586445,-0.031021034,0.0076971822,-0.06658321,0.07701898,-0.018567128,0.045871854,0.07284736,-0.014960725,0.025161473,0.05185787,0.03021986,-0.058485873,-0.031105487,-0.018845996,0.035695605,0.030996937,0.03453858,0.06432756,0.013441129,-0.04905819,0.05971625,-0.04462679,-0.035036277,-0.018574402,0.042236514,0.057261236,-0.039485004,0.056433823,-0.008829253,0.058267735,0.07605983,-0.048676576,0.040291607,0.028522497,0.02338339,-0.011058826,0.06377806,-0.017907081,-0.019664949,0.044045076,-0.07991085,0.013588595,0.024177928,-0.05488742,0.0059404625,-0.052893177,0.055437103,-0.007805027,-0.054251112,-0.037396133,-0.07472886,0.040037263,0.0459502,0.0018798365,0.06253658,-0.060931712,0.09448631,-0.07764294,-0.04016598,0.036615998,0.03421174,0.032680888,0.029329386,-0.031335074,-0.058834735,-0.030677319,-0.034905817,0.06689594,-0.03750603,-0.06127292,0.021906741,0.01247035,-0.058054022,0.025653442,-0.055755254,0.09835061,0.0022345665,-0.03380796,0.006731517,0.041788824,-0.049650397,-0.051438887,0.037636273,-0.0054148273,-2.471318e-08,0.06657653,0.0130916275,0.08369635,-0.07083796,0.05296065,0.006731384,0.041300982,0.087547556,0.088365205,-0.023515541,0.016900877,0.06637996,0.03494091,-0.01608956,0.042121336,0.057343364,-0.09846489,-0.030177673,-0.042372126,-0.0006367307,-0.048136305,-0.069552995,-0.06309567,0.024842864,-0.03091589,-0.004829207,0.06853876,0.067517534,-0.00687104,-0.083701804,-0.051452946,-0.00078296266,-0.017660916,-0.02119399,-0.017635297,0.020887567,0.02161678,-0.063971035,-0.024551874,0.018162956,-0.030080287,0.018412566,-0.054535214,0.019076664,-0.00090243376,-0.0056765135,0.02032155,0.06828062,-0.0048957407,0.035915498,0.02144696,-0.007092731,0.004420924,-0.024302088,-0.105366066,-0.109405816,0.041486863,-0.014091634,-0.062744305,0.045986056,0.049039677,-0.046922244,0.1797771,-0.027029293 +2.7.1.213,"The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in a pathway for nucleoside degradation. The enzyme can also act on deoxycytidine and uridine, but unlike EC 2.7.1.48, uridine kinase, it is most active with cytidine.",384,0.99999994,-0.08901664,-0.0042685107,-0.098827,-0.033017863,0.084104516,0.008556193,-0.073021375,0.04176213,0.03513326,-0.0033557527,0.0056359535,-0.048951343,-0.026332732,0.11189084,-0.054962937,0.032843508,-0.12357657,0.056492716,0.05387324,-0.016780915,0.046689823,0.03543303,-0.028982898,0.0407867,-0.0022919949,-0.0074317176,0.025413021,0.061249115,-0.08741838,-0.019455757,-0.049600232,-0.02617787,0.082917966,-0.028781168,0.10772179,0.0997759,-0.07094558,-0.058379095,0.041352354,0.0420732,0.06659323,-0.00084017863,0.009284252,-0.013769614,-0.0021461574,0.022557193,-0.045001443,0.023191564,0.023694841,0.0047305953,-0.022638287,-0.025012253,0.009013071,0.007976388,0.037165076,0.057730123,-0.10467588,-0.047506128,-0.011299473,-0.0030564242,0.08348833,-0.009474022,-0.01242659,0.052271966,0.032125134,-0.056174453,0.053822096,-0.03767565,0.012801866,-0.08069498,-0.09336922,-0.078104034,-0.020647712,0.07953742,0.0025110515,-0.0034152265,-0.020572333,-0.053994592,-0.0026990161,-0.038207304,0.044321302,-0.07329932,-0.016971631,-0.00072537246,0.05557683,-0.0014504514,0.034126926,-0.0386497,0.045880426,0.03055059,0.076006256,0.037441924,-0.0037965341,-0.12633768,-0.023014057,-0.0039492226,6.6527784e-05,0.0897982,-0.025344035,-0.010054906,0.0053224377,0.03597304,-0.087066755,-0.09922311,0.038974177,-0.0019933379,0.08219693,0.0142679075,0.049624026,0.04019974,-0.021759063,-0.056752928,0.022445504,-0.01179622,0.036776274,0.1027825,0.036086764,-0.038818616,-0.08307013,-0.0032201863,-0.04163477,-0.08256188,0.028950013,0.045718446,-0.10250598,0.089831956,-0.06814086,1.8780078e-33,0.03749668,0.0029753025,0.005567218,-0.04338852,0.04517522,-0.020876495,0.0023669712,0.0004276274,-0.03535909,-0.16735981,-0.09566806,-0.0020877512,0.08337876,-0.0069359774,-0.057539083,0.030101782,-0.0038115352,0.024441808,0.005141134,0.012305942,0.084029205,0.09081804,0.01169923,0.018064678,0.06488146,0.033614296,-0.052198872,-0.013060029,-0.01949942,-0.0064982194,-0.04636772,-0.09022149,-0.14495142,0.03170188,0.05704741,-0.00800972,-0.085227475,-0.014596417,-0.004577464,0.03238207,-0.06809189,-0.0017314496,0.036556773,0.000100945756,0.008609492,0.020369805,-0.0145716835,0.13194694,-0.031723622,0.05606452,0.024010062,-0.04516481,-0.006697329,-0.036416464,-0.049009323,0.020944785,0.012199095,-0.035140593,0.018791262,0.00071094494,0.009533576,0.059396926,-0.05540117,0.02540715,0.021236638,0.040216595,-0.12612341,-0.020053873,0.008349834,0.060121555,-0.04503275,-0.00088459864,0.038570266,0.004969816,0.036818616,0.02732854,-0.1022808,-0.0068114707,-0.008278907,-0.0048896777,-0.04551589,-0.03657979,0.038462587,0.018482171,-0.03455043,-0.056876663,0.03414064,-0.023119772,-0.025891725,0.04467939,0.05912448,-0.08981836,-0.057820484,0.052050594,0.024645,-3.220786e-33,0.12768452,-0.058515936,0.06846639,-0.048216335,-0.07511531,0.050930604,0.01387717,-0.020026693,0.03076931,-0.032009333,0.08220518,-0.0261026,0.027451446,-0.04458471,0.050005708,0.0020365592,-0.004149837,0.07890851,-0.042171407,0.0048392904,-0.031722106,0.024188148,-0.047966775,0.0049859257,0.0059677367,0.022842327,0.016499152,0.019169549,0.06571165,-0.041733097,-0.08607577,0.051737916,-0.056923043,-0.058027085,0.031229729,0.08293351,-0.0125988135,-0.055254944,0.0395083,-0.026811313,0.04378774,0.017085623,-0.046437874,0.086957544,0.061096217,0.07025955,-0.011245402,0.035729013,-0.044832516,-0.037434187,0.057879426,-0.03287246,0.0123175895,0.052200764,-0.0064581945,0.053087346,-0.04285024,0.0742601,-0.06553885,0.0049626785,-0.013122173,-0.06836494,0.011742318,0.04059079,-0.007496497,0.0031280557,-0.07646391,0.1103794,-0.035503592,-0.019853326,0.06527048,-0.005215986,0.031299546,-0.008763636,-0.08557693,-0.06958955,-0.05333117,-0.0314055,0.057335597,-0.016473152,-0.07071099,0.025838962,-0.023520691,-0.031817682,0.00073521683,-0.0041561094,0.0771475,-0.0008570531,-0.034901645,-0.037399955,0.025052255,-0.03308341,-0.060184564,0.09025709,0.020854881,-3.587024e-08,0.069454044,-0.017895786,0.061198268,-0.07190234,0.049460802,0.025490744,0.0453299,0.09830533,0.0655291,-0.01866227,0.04240268,0.08741078,0.041478246,-0.02423811,0.040693976,0.054087743,-0.09782561,-0.015028508,-0.010109408,0.0060957205,-0.017420666,-0.083487354,-0.10351157,0.043013096,-0.014368693,-0.036801003,0.06438949,0.063131355,-0.005737993,-0.084644064,-0.008741977,-0.04135643,-0.0014177082,0.02112675,-0.029594785,0.03974315,-0.021305678,-0.07039311,-0.016190127,0.02547109,-0.006602727,-0.007119219,-0.082636274,0.024184778,0.01000753,-0.0016214553,0.059433393,0.008203979,-0.00123108,-0.009711709,0.0035193292,-0.0062696333,-0.0025305217,-0.033677354,-0.06332043,-0.030403133,0.0044461065,-0.033075552,-0.016809337,0.01331095,0.066904806,-0.021535227,0.20251985,0.041133925 +2.7.1.214,"The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A.",384,1.0,-0.046776224,0.04090034,-0.15851124,-0.01825793,-0.0016604685,0.041087188,-0.059247777,0.0883598,0.07990498,-0.03757839,0.06478709,0.013845519,0.028911948,0.016371477,-0.06804943,-0.022790328,-0.054432712,0.025386378,-0.006721044,-0.105243154,0.08820197,0.057507947,0.008589434,-0.01228664,0.014416271,-0.06439657,0.017968757,0.05861471,-0.009657709,-0.07628081,0.032846544,-0.0051105334,0.032003213,-0.063582614,0.08660176,0.11720016,-0.022639394,-0.07335915,0.14007007,0.014248987,-0.018655991,-0.047539037,-1.3656872e-05,-0.03401567,-0.07626365,0.021137312,0.019768588,0.04593198,0.04354799,-0.010560461,-0.08170001,-0.063498735,-0.06314266,0.024911236,0.058319688,0.08812598,-0.03157502,-0.040784493,-0.04027476,-0.0699571,0.04203874,0.0014456209,0.03059696,0.055492245,-0.114004575,-0.034674436,-0.015873173,-0.066836715,0.04975883,-0.045177743,-0.07926637,0.004612804,-0.0032092198,0.06527694,-0.0101750465,0.019722184,-0.009310971,-0.033827826,0.03238971,-0.058561627,0.05394912,-0.02096519,0.04829757,0.06889824,0.031099327,-0.0016371532,-0.0012387746,0.0014069782,0.09772852,0.020825218,0.079690024,-0.013153439,0.014703797,-0.005399298,-0.0046753064,0.029412854,-0.03977273,0.020213732,0.006329903,0.014368198,-0.015246866,-0.027805794,0.010266445,-0.00825177,0.01653423,0.019482646,-0.013908377,0.021189462,0.07560827,-0.042179875,-0.0140386345,-0.01828156,0.024089746,-0.022905169,-0.0075628785,0.05688994,0.1371033,-0.001961558,-0.13858213,-0.061359502,0.018146683,0.02837188,0.050132744,-0.055698004,-0.012608253,-0.017953066,-0.09576542,1.4234467e-33,-0.019293083,0.07291865,-0.0035257516,-0.06222692,0.03523987,-0.020447467,-0.03853212,-0.020581163,-0.052165,-0.044759028,-0.095158,-0.055866987,-0.075258896,0.03087708,0.019093266,0.014914214,0.02672169,0.06700191,-0.019263571,0.010970632,0.045905262,0.021944026,-0.011343331,-0.00021144928,-0.017138887,0.05700955,0.023864996,-0.00042939637,0.084227756,-0.0048032533,-0.029097749,-0.07439838,-0.04618771,0.010183159,0.054251526,-0.0112932185,-0.06468204,-0.052283946,0.031185338,0.03081917,-0.03137603,0.025348442,0.009898044,-0.01941749,0.04417846,-0.0261595,-0.066293806,0.046430275,0.109769896,0.053641267,0.0037803822,-0.027399275,0.10694363,0.006608328,-0.036927268,0.0026309665,-0.02984935,0.087267034,0.02610673,0.029084304,-0.006106086,0.03775269,-0.02161603,0.063441984,0.03544715,-0.034170277,-0.022932084,-0.040866338,-0.029880136,0.028813126,-0.017326383,-0.041429088,-0.03266918,0.06122219,0.027555028,-0.0878694,-0.06363577,-0.044195194,0.021323904,-0.022157501,-0.055979248,-0.01476585,-0.016140165,-0.021946553,-0.06749107,0.029041484,-0.050286837,-0.019111423,0.02238494,0.074031405,-0.016531708,-0.03963818,-0.04578225,0.0694169,0.034817215,-3.7127464e-33,0.06193904,-0.057616033,0.040694177,0.008207033,-0.035660893,0.11095978,-0.0033908528,-0.014997958,-0.032114267,-0.033369936,0.051847477,-0.049296092,-0.010607793,-0.0899563,-0.0028578807,-0.016947277,0.038046625,0.10727434,-0.054504905,0.065799244,0.012720851,0.07885631,-0.03976744,-0.015358325,0.021706404,0.02132529,0.04381472,0.09734344,-0.065667436,0.10768169,0.041815523,-0.030119833,-0.05850521,-0.032601677,-0.0090685375,0.039479274,-0.0090333745,-0.043387488,0.09100662,0.0072298874,0.08380031,0.018565057,0.02035853,0.022536207,-0.008317273,0.087837294,-0.090428665,0.06142943,0.028302109,-0.09498388,-0.04270851,0.060866944,-0.013053132,0.038496725,0.005407623,0.001394484,-0.05175967,0.028528368,-0.028613562,0.0034396255,-0.049672708,-0.05807993,-0.002552109,0.044974606,0.07736636,0.0778605,-0.014449964,0.032819882,0.10617677,-0.047704056,0.09675269,0.019457022,-0.041227706,0.038057216,0.009463226,0.0050209574,-0.09173538,-0.08342164,0.022574235,0.002814131,-0.0025706908,-0.028389895,0.061353073,-0.059817836,-0.04809191,-0.11270557,0.052304342,0.0504018,-0.046633378,0.030198265,0.05987815,-0.0034222002,-0.04612041,-0.012042172,0.06374916,-3.409836e-08,0.014496446,-0.07514495,0.088519275,-0.07121211,-0.030566517,-0.047020894,-0.03775419,-0.024179809,0.04852518,-0.004832956,-0.04371599,0.023579873,0.0049442453,-0.013596766,-0.029903695,-0.036354795,-0.058522917,0.10182536,-0.021270558,-0.023530727,-0.051389553,-0.04159918,-0.11366553,0.007800996,0.0743378,-0.03886787,0.0148927225,0.0040639704,0.010933364,0.00011025451,0.022649473,-0.018916706,-0.012296335,-0.018496787,-0.07923292,0.021887584,-0.05335985,-0.041449547,0.06332783,-0.041336868,0.06322679,-0.041267157,-0.047435246,-0.021909034,-0.054182153,0.022072393,0.022488665,-0.027572637,-0.07780778,-0.011033984,0.035762303,0.004641066,0.05030886,-0.017795866,-0.096624605,-0.027918102,0.025547214,-0.02901102,-0.035694916,-0.07059393,0.008612167,0.0057478365,0.22587799,-0.070762694 +2.7.1.215,"The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism. cf. EC 2.7.1.27, erythritol kinase (D-erythritol 4-phosphate-forming).",384,0.99999994,-0.03628252,-0.011014219,-0.114092894,0.110594824,0.0006659212,0.007489103,0.03176582,0.047426566,0.046182282,0.016477698,-0.031055914,-0.06351202,0.03706891,0.025169818,-0.06709875,0.07863718,-0.051750083,-0.009387882,-0.0635705,-0.002474206,0.003621584,0.07512149,0.016069084,0.029887805,-0.04987042,-0.0689932,0.06223883,0.06388289,-0.059862163,-0.08819405,-0.06611467,-0.041617002,0.06861391,-0.010919353,0.055625144,0.011231119,0.04350297,-0.05323871,-0.034157347,-0.061226904,0.056219574,-0.0106158145,0.028906072,0.030213108,-0.0046445546,0.028477034,0.015442704,0.030786444,0.079042695,0.027431915,-0.059293054,-0.025018478,-0.021002391,0.06488374,0.010715773,-0.05081338,-0.051516872,-0.060089104,0.022947742,0.013865659,0.055618722,0.012623035,0.031815868,0.019063951,0.014498271,0.005535023,0.004410674,-0.09974652,-0.0823067,-0.027245885,-0.07419641,-0.17242725,-0.031940937,0.072851494,-0.020674055,0.046513543,0.052687872,-0.002062868,0.041653845,-0.04021077,-0.015153575,-0.0040422035,0.085951224,0.04967265,0.036997885,0.08153006,0.005152643,-0.055273704,0.0086661605,0.030209184,0.023443433,-0.082452804,0.010884218,-0.01745957,0.002767006,-0.016887572,0.049711086,-0.052630186,-0.0081617655,0.04336937,-0.10197258,-0.010437647,0.022477947,-0.022333087,-0.023118008,-0.03567227,-0.011846505,0.039845552,0.013233823,-0.016959844,-0.0071615907,0.040779036,-0.0465395,0.0743245,0.080767214,0.07584625,0.066242285,-0.06446635,-0.113814615,0.0047501265,0.011591154,0.005202748,0.002198195,0.032531995,-0.0042332597,-0.02832681,-0.036374994,1.3660612e-33,0.014259322,-0.07084509,-0.04652783,-0.0013140681,0.055010956,-0.016386084,-0.051133648,0.02554604,0.023853572,-0.023306185,-0.08169811,-0.081480905,0.12698793,0.021394959,-0.037207704,-0.022352176,-0.017869437,-0.0099193575,0.065393254,-0.026339734,0.047096238,0.033235323,-0.03313864,-0.06280099,-0.048319664,0.050676875,-0.012021955,-0.00012222142,0.04392185,0.0064219646,0.027500989,-0.07688924,-0.06589496,-0.029734729,0.043626092,-2.9520734e-05,0.029886782,0.012480046,-0.021900682,0.03142247,-0.03263163,0.007433197,-0.055502236,0.016859768,0.04564302,-0.09698146,-0.019264117,0.10235139,0.045462713,0.030283531,0.035156697,0.013663242,0.10194148,-0.023174496,-0.06838369,0.054005023,-0.015059094,-0.04733643,0.05144412,0.017467968,0.03973522,0.03679423,-0.03297845,0.018975098,0.005308471,-0.04069542,-0.0059773894,-0.0343579,-0.04565197,0.06437105,0.019421004,-0.00534862,0.097641006,-0.03781328,-0.08454083,-0.007832274,-0.070111744,0.051279698,0.03347178,0.021529343,0.0072288094,-0.03498282,-0.009830817,0.022514202,-0.021962872,0.028629385,-0.047845893,-0.055303924,-0.055271957,-0.0019218128,0.12467732,-0.0069853608,-0.10622852,0.0015097696,0.030716153,-1.708656e-33,0.07866477,-0.029743196,0.007899691,-0.011284168,-0.033749107,0.0019832714,0.032006722,0.020071715,-0.017653001,-0.043908954,0.14311084,0.07104834,-0.015362636,0.002998853,0.00882459,-0.011050214,-0.027328568,0.04557162,0.0095593305,-0.052351054,-0.05365907,-0.006522835,-0.030124618,-0.094460726,-0.008778301,0.08098921,-0.08059862,0.052640785,-0.015002987,-0.022922907,-0.020279475,0.005772318,-0.0019261913,-0.12266575,-0.04661758,0.018337809,-0.0658193,-0.027081057,-0.023454998,-0.06995201,0.046852235,0.035691682,-0.08171599,0.06097625,0.071797796,0.15145563,-0.047248647,0.07425929,0.09891571,0.026928017,0.048502225,0.065330766,0.051561475,0.03537501,0.005786006,0.021714069,0.056347016,-0.059696004,-0.073562145,0.049497347,-0.0605062,0.039198063,0.122939706,0.030317351,0.07650726,0.036482662,-0.044111617,0.029129969,0.053063147,0.009601502,0.06086455,0.03914567,-0.03240419,-0.0136877755,-0.14226107,0.038532607,0.027251536,-0.030660355,-0.007485264,0.0043267044,-0.005613597,-0.0043188953,0.006006143,0.026552582,-0.0946805,-0.06558217,-0.007328318,0.050479412,0.061897304,0.0076367585,-0.005397968,-0.07590859,-0.025684873,0.06786051,0.043227013,-3.3219674e-08,-0.057303283,-0.044622287,-0.030513277,-0.06709318,0.0715865,0.042187385,-0.092504136,0.04354101,0.07385813,-0.020925255,-0.025453765,0.08340315,-0.054792598,0.013163108,0.02550476,0.04491591,0.05814431,-0.06839505,0.024026878,-0.06294522,-0.045007836,-0.06676811,-0.013671607,-0.045766093,0.069802955,-0.0897787,-0.07522194,0.053019613,-0.0096033355,-0.009262861,-0.04711348,0.04200679,-0.007079995,0.015422869,-0.06637286,0.005032675,-0.08415487,-0.058937673,-0.024639674,-0.009032625,0.039710294,0.026134787,0.014597216,-0.010891668,0.0024248736,0.03979944,-0.03646444,-0.0014724967,0.025511624,-0.116067745,-0.015408044,-0.010074864,0.05981595,0.006727985,-0.08602719,0.092004046,-0.009920799,-0.07723421,0.07750085,0.04811324,0.024617732,0.0022321357,0.10494396,0.027275894 +2.7.7.91,"The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.",384,0.99999994,-0.033391986,0.041346725,-0.16520508,-0.014067302,0.011176358,0.06632812,-0.08761877,0.070771575,0.09371555,-0.049065135,0.020304933,-0.015653556,0.019812433,0.0038618445,-0.08952559,-0.022682177,-0.03915205,0.0031212731,-0.015515301,-0.054854743,0.10089011,0.059249684,-0.0011745252,0.0008781401,0.01968139,-0.05761602,0.01527657,0.035693806,-0.048022043,-0.07430026,0.04562834,0.010529907,0.048223443,-0.043757297,0.08842224,0.089192264,-0.012082253,-0.068381496,0.1561028,0.031800356,0.0071368087,-0.058023978,-0.039972957,-0.015889358,-0.06352762,0.018284867,0.011398258,0.047118884,0.033562925,-0.0057637715,-0.068649314,-0.054201115,-0.06409468,0.033256833,0.02711098,0.034821674,-0.0020329896,-0.014903098,0.0037943064,-0.09169852,0.06571657,-0.009816365,0.017377663,0.069076814,-0.1286724,-0.03240107,-0.00870449,-0.084725454,0.027957376,-0.020438343,-0.058344044,-0.0101078665,-0.06495778,0.072738856,0.013864774,0.037635192,4.6406778e-05,-0.07174077,0.0022523287,-0.058447413,0.0681575,0.013611885,0.002249433,0.06490915,0.007853562,0.019890714,0.0064531593,-0.009830039,0.07208349,-0.011253916,0.06072654,-0.059416417,-0.008021549,-0.048073903,0.0068513453,-0.0038743098,-0.028544404,-0.012964682,0.032229684,-0.00589353,-0.048818108,-0.017862756,-0.018153025,-0.045191575,-0.035075396,0.030264037,-0.0126670515,0.028639449,0.066902906,-0.040945962,-0.011018382,-0.025360798,0.04320837,-0.030613685,-0.02218026,0.05713647,0.14359418,-0.011759733,-0.09932621,-0.053710982,0.023656966,-0.00020415637,0.067502424,-0.02310155,-0.00832304,-0.029191922,-0.10335747,1.2570804e-33,-0.031630486,0.026252575,-0.0006182106,-0.056884915,0.07037732,-0.0134632485,-0.04746976,-0.008622511,-0.02213726,-0.048824728,-0.091774486,-0.06167053,-0.051043473,0.041520316,-0.003894097,0.01978163,0.021985713,0.05989485,-0.055608615,0.0024067294,-0.0001324441,0.02786378,-0.016752334,0.0126794,0.00014385056,0.04788087,0.032190748,0.017877102,0.11024584,-0.032657355,-0.020872986,-0.06886545,-0.00703884,0.012141374,0.050616328,0.014565096,-0.080725566,-0.045254517,0.038316403,0.00085308816,-0.01270338,0.01875392,0.0018975848,-0.020006264,0.005791875,-0.032440536,-0.069991596,0.06520384,0.08547997,0.049989797,0.05351102,-0.00955729,0.11376349,-0.009566554,-0.05732527,0.014750755,-0.049806982,0.08206222,0.03823423,0.042619545,0.01557833,0.053391848,0.015661867,0.058237433,0.029538764,-0.016825343,-0.07984565,-0.013674685,5.9484515e-05,0.04914747,-0.0447442,-0.012464166,-0.015698481,0.05797553,0.031284098,-0.052044924,-0.050706286,-0.02715033,0.02412795,-0.00028776436,-0.06603898,-0.009600081,0.019137314,-0.027001752,-0.07106107,-0.010864685,-0.04981357,-0.022115415,0.0019445292,0.07281656,-0.065088384,-0.046588633,-0.08647359,0.07629036,0.050036296,-4.1447192e-33,0.080296926,-0.0694782,0.07455233,0.010163593,-0.00878193,0.12581347,-0.022233868,-0.032513667,-0.022128763,-0.029407388,0.07456795,-0.044994555,-0.008160754,-0.06738269,0.04582577,-0.015644567,0.004705742,0.048052754,-0.07280281,0.06297683,-0.02969876,0.07543247,-0.056276508,-0.0055982075,0.032094806,0.0052814074,-0.016741643,0.09943229,-0.04856109,0.09108777,0.07016095,-0.01279546,-0.059249632,-0.012318617,-0.009887355,0.09331918,0.009426801,-0.018283917,0.092638664,0.0048181573,0.09272846,-0.024505753,-0.0010190802,0.04347445,0.022535644,0.057729434,-0.07378339,0.035086345,0.014632786,-0.059222605,-0.0337204,0.06013725,-0.007301785,0.04815264,0.046829067,0.036202047,-0.03112361,0.024106855,-0.014210354,-0.0428724,-0.078126594,-0.048658196,0.01690931,0.050470915,0.05557787,0.032648116,-0.004566137,0.0022755333,0.11983958,-0.071710505,0.11185518,0.036345683,-0.047384262,0.07134728,-0.008347309,-0.019297969,-0.06669342,-0.07458134,0.022428956,0.0047763847,-0.03627569,-0.049997725,0.04280455,-0.038443577,-0.025017971,-0.073368385,0.05567005,0.011107286,-0.041580625,0.04305114,0.052424762,-0.012675479,-0.031260613,-0.013603103,0.059338138,-3.2152748e-08,0.041029733,-0.051611938,0.09220014,-0.04888133,-0.018643172,-0.06691862,-0.0012195595,-0.014248469,0.0024153062,-0.0027926594,-0.023648063,-0.018355815,-0.00088759087,-0.044994026,0.0052475366,-0.031769525,-0.06879498,0.07358072,-0.006515319,0.0076542185,-0.046424303,-0.028135741,-0.12455827,0.02637417,0.06272835,-0.07187232,0.023666,-0.0076064807,-0.028580008,-0.006121484,0.070410214,0.0047826036,-0.03681728,-0.020580793,-0.07167377,0.025853708,-0.065424494,-0.02137939,0.058103006,0.014685165,0.04091745,-0.0013374527,-0.08582369,-0.04078829,-0.08111445,0.027959518,0.0010642458,-0.023605194,-0.097340025,0.011416939,0.05117747,0.040032294,0.03219928,0.0013599842,-0.089946315,-0.012482271,0.025689801,-0.0050011566,-0.052454527,-0.04994735,-0.0030718776,0.015510813,0.2485598,-0.06426597 +2.7.7.92,"The enzyme is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.",384,0.99999994,-0.05044856,-0.095150985,-0.0683935,-0.029881919,-0.009609641,0.07133525,-0.007778614,-0.023579152,0.03392461,0.009734136,0.05160736,-0.010581026,-0.06814913,0.014277795,-0.072783716,0.008412211,-0.044900816,-0.014634566,-0.038628552,0.029680414,0.08857534,0.02805033,0.025799453,-0.0109749,0.07436902,-0.010612332,0.03281257,-0.03567448,-0.005266118,-0.04496674,-0.02395026,-0.0540695,0.08758813,-0.044432748,0.06951067,0.035210267,-0.016365958,-0.0069336696,0.06191892,0.019445477,0.02814333,0.0016110704,-0.005029555,-0.019298503,-0.022970323,0.007911567,-0.054251157,-0.0012968956,0.05475008,0.022593372,-0.002606126,-0.081633784,-0.018472904,-0.0037420702,0.07177772,0.07425948,-0.085913755,-0.034237638,0.039585914,0.018234702,0.09830594,0.023558175,0.029494012,0.048793662,-0.015499943,-0.038979154,0.08663255,-0.008082319,-0.015439884,-0.03225096,0.018148161,-0.072900765,-0.054144397,-0.021475675,-0.0039659673,0.018137908,-0.0069214115,-0.040645786,-0.010621459,-0.05063616,0.06893659,0.056674816,-0.01740619,0.030794755,-0.04814795,-0.05945806,0.023492591,0.0268777,-0.04391942,-0.031981885,0.016541526,-0.057267137,0.0032613988,-0.10323921,-0.059050966,0.044270594,0.07333777,0.02163376,0.03222782,-0.027468227,-0.05220668,0.018254802,0.0169837,-0.08649525,-0.0467663,0.02106448,-0.012115995,0.047071397,0.06182952,-0.01734765,-0.028091246,0.05863549,-0.017917113,0.04456187,0.00262802,0.02435782,0.067480445,-0.12788877,-0.028043164,0.026165392,0.017161045,-0.09970165,0.054856308,0.07624383,-0.029347152,0.088357314,-0.052403595,1.9350274e-33,0.115930356,-0.035422362,0.016588563,-0.074291274,0.06262382,-0.0400773,-0.11342907,-0.034770925,-0.061386686,-0.06671495,-0.11784116,-0.07314406,0.027999956,0.071377456,-0.008585248,0.0945939,-0.010444565,-0.015458577,0.088136956,0.006478566,0.059234295,0.010474995,-0.031282652,-0.014342549,0.0068048844,0.049693212,-0.0047126147,0.05081547,0.06222316,-0.002506422,0.050169982,-0.13843682,-0.0555014,0.026915295,0.05395193,0.012232043,-0.07317982,-0.026701348,-0.00024649643,0.07172593,-0.009712282,-0.004669611,-0.0054994985,-0.0033033413,0.019889152,0.015273168,-0.03510917,0.02697348,0.020790527,0.056840435,0.026065996,-0.018160861,0.058136597,0.007781119,-0.010720619,0.06979316,0.0114606125,-0.026124807,-0.01064415,0.024434393,-0.010962322,0.009338144,-0.045854557,0.07914771,0.03484371,0.019621413,-0.08575634,0.016784767,0.033823125,-0.034733366,-0.07740923,-0.020102847,-0.0006229297,0.010038201,-0.018956605,-0.039494053,-0.007560393,-0.030001897,-0.02331241,0.029849498,-0.037562232,0.024587648,-0.06435268,-0.04766548,-0.03641432,0.015002886,-0.06240721,-0.069122545,0.0034467087,0.015082729,-0.048143674,-0.04487749,-0.08991715,0.00022326806,-0.021228107,-4.800234e-33,0.108712494,-0.08610581,0.09214177,-0.056125198,-0.010742316,0.14124285,0.058544002,0.06418765,-0.006207956,0.012297226,0.045436352,0.029880524,0.01366066,-0.03292532,0.069454096,0.052295435,0.013591973,0.08683062,-0.008930234,-0.053299937,0.029087145,0.012380422,-0.012965116,0.040383846,0.027011523,-0.006862314,-0.052944727,0.07043073,-0.06230596,0.08993696,-0.00188064,-0.0037809988,-0.09035789,-0.052467063,-0.030639827,0.015626436,-0.051325507,-0.0031249418,-0.032323,-0.016532715,0.00980961,0.06582075,0.02802936,0.067791164,0.055491608,0.073646076,-0.061686173,-0.0028467362,0.041433014,-0.044428065,0.04984247,-0.025611395,0.048559513,0.0531596,0.06592348,0.04926453,0.05694588,0.13443358,-0.023681002,-0.059919644,-0.065613024,-0.107488655,0.058631286,-0.05519687,0.052915756,0.04949581,-0.03237694,0.060481947,0.026775457,-0.06034209,0.008911114,-0.04863216,-0.036025446,0.057404026,-0.08657745,-0.026508328,-0.108099505,-0.02753983,0.03221336,0.045651402,0.06438546,0.010183077,-0.040925927,-0.037175864,-0.003181592,-0.03131541,0.07327952,0.10765566,0.024505086,-0.0038610098,-0.07241363,0.016112348,-0.122498296,0.020348191,0.047158524,-4.199309e-08,0.056818366,-0.06564542,0.016275747,-0.09854887,0.00560835,-0.010874744,0.003576054,0.008710939,0.011242372,-0.081069,0.02649062,0.10230775,-0.041273512,-0.006849963,0.012341883,0.037276544,-0.016735364,-0.0007690361,-0.029273177,0.021024551,-0.09233326,0.035307374,-0.087158926,0.048884027,-0.021342473,-0.04938816,0.019805625,0.056004975,0.017044572,-0.005850186,0.035744786,-0.00833835,-0.07426032,-0.027059047,-0.060397334,0.022207918,-0.06594238,-0.054615293,0.03941672,0.018970931,-0.024421113,-0.016227817,-0.012917611,0.016069569,-0.08101087,0.022077123,-0.01756129,0.080406204,-0.054397024,0.019688895,-0.030132774,-0.09050541,-0.06641516,-0.05720697,-0.14746135,-0.022899719,0.013845295,-0.087499805,-0.02564182,-0.0053348667,0.007982438,0.03386751,0.17387497,0.033970013 +2.7.7.93,"The enzyme, characterized from the bacterium Streptomyces viridochromogenes, participates in the biosynthesis of the herbicide antibiotic bialaphos. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase.",384,0.99999994,0.004342296,0.02060839,-0.15311243,-0.047527317,0.026332423,0.09212734,-0.04775817,0.06100194,0.08704572,0.0313894,0.02451699,-0.029904876,0.0021944602,-0.035729833,-0.03276328,0.02035011,-0.047143757,0.01149631,0.019423507,-0.052634027,0.09608711,0.10273799,-0.02083666,0.035588663,0.0045758537,0.017697046,0.06392291,-0.008051778,-0.004196489,-0.056835145,-0.0059803347,-0.011340829,0.051091067,-0.09912954,0.048284587,0.08193808,-0.035969436,-0.07031753,0.13298069,0.02403785,-0.019194972,0.03110803,-0.0024572313,-0.045728434,-0.03880665,0.032473598,0.034482002,0.09696979,0.032794,-0.026194848,-0.0103211235,-0.03901028,-0.07266269,0.048182234,0.012257279,0.023458315,-0.09284321,-0.016016072,0.0103099095,-0.0017032186,0.0019790246,0.029335717,0.036806047,-0.0029083346,-0.04496951,-0.06292778,0.044008303,-0.09161814,0.02891454,-0.060375758,-0.05668698,-0.10320715,0.03374504,0.049570043,0.006785262,0.025313724,0.01175578,0.026193177,0.00403103,-0.046950955,0.04012191,-0.08414488,-0.02353227,0.09687725,0.001524011,0.025939196,-0.0065161986,-0.005048731,0.14881997,-0.010521763,0.06492851,-0.057674978,0.03419862,-0.101693876,-0.055706862,0.013505706,-0.060972128,-0.02285053,0.007075105,-0.0019243927,-0.007889335,-0.0049713803,-0.015664088,-0.03931648,-0.027665522,0.021634253,0.015587366,0.08534779,0.019419087,-0.021040585,0.008571896,0.016551854,0.0032596136,-0.036160897,-0.09253341,0.060776476,0.121338904,-0.08996298,-0.084829696,0.007817914,0.06618158,-0.028043387,0.0574353,0.06056643,-0.042451724,0.011727442,-0.09821055,4.6685155e-33,0.034664508,-0.013238099,0.02714695,-0.057237063,0.07448873,0.00078656257,-0.05805255,-0.044322807,0.008101598,-0.11225628,-0.12318501,-0.069556944,0.0372802,0.039071456,0.0013630004,0.015992979,-0.016047318,0.011567784,0.059375677,0.009258601,0.020254048,0.011757953,-0.036305286,0.061137173,0.005910013,0.100797415,-0.011851364,-0.02139151,0.023320576,-0.01580875,-0.00026683256,-0.024863742,-0.06024833,-0.019570041,0.029064175,-0.05969354,-0.09014842,-0.09398957,0.083361536,0.028177006,-0.00622606,0.0060179834,-0.012312639,0.011828154,0.055049155,-0.057121843,-0.01951937,0.066901624,0.038310785,0.11787494,0.0410804,-0.03304172,0.09003438,0.004675975,-0.084690526,0.05843443,-0.0150725795,-0.037169147,0.06030306,0.091841236,-0.026865944,0.08099697,-0.01857141,-0.033336356,0.025617598,-0.026052682,-0.024181342,-0.036784858,-0.006419696,0.041874338,-0.064791545,-0.06781249,0.0055393763,0.0782514,0.008378937,-0.08055642,-0.074113674,-0.005559488,0.005297928,0.0019279127,0.032633565,0.035043187,0.026286539,-0.014659202,-0.03590392,-0.009224996,-0.011072549,-0.09253975,-0.009723261,0.028032007,0.03021814,-0.03402127,-0.103708126,0.058869198,-0.0031408812,-5.2772897e-33,0.08181975,-0.06895525,0.053823035,-0.035060592,-0.008662394,0.0041009113,0.0061846618,-0.06331829,0.018209312,0.0014931317,0.03767321,-0.017726228,-0.062964045,-0.038743593,0.0111160055,-0.03283376,0.04299822,0.0676656,-0.03699434,-0.0013544254,-0.021996463,0.041768495,0.017741613,-0.03967725,0.017815193,-0.05065763,0.0034054527,0.09650271,0.02952467,0.057377815,0.003193197,0.008956919,-0.027665237,-0.036923084,-0.010698158,0.032321826,-0.012468819,0.036947012,0.042523686,-0.05289726,0.08709116,0.04148186,0.005709012,0.009697139,0.012143517,0.057145037,-0.04410577,0.0755372,-0.083159044,-0.06290029,0.043871798,0.047351867,0.03344622,0.02748795,0.028740061,-0.011369905,0.0021563368,0.002556718,0.021410407,0.010058094,-0.019966107,-0.05275352,0.03885906,0.023207648,0.08024592,0.02957484,0.0039062775,0.071736045,0.08072856,0.0039624916,0.041037768,-0.009115474,0.022993023,-0.004284454,-0.069126636,-0.016873233,-0.07531415,-0.07868907,0.039179955,-0.07005855,-0.004981837,-0.03502018,0.047081497,-0.037705336,-0.05080074,-0.024672238,-0.011139362,0.0928451,0.031065246,0.08871697,-0.04380201,-0.05352317,0.0068149,0.07709278,0.05992829,-4.19893e-08,0.014946398,-0.025300344,0.01848169,-0.031888332,-0.0005687924,0.008718704,-0.025506701,0.0042354157,0.032046903,-0.022815472,-0.012186816,0.017383514,-0.008388869,-0.046593677,-0.007359081,0.11290815,-0.0832878,0.05850889,-0.030761188,0.061492406,-0.02859591,0.005407247,-0.14406025,0.006341286,0.051564775,-0.056053575,0.03617226,0.027895715,-0.02092121,0.028994858,0.0074909306,-0.00023547567,-0.024507478,-0.052374233,-0.106090374,-0.08449743,-0.078101344,-0.036334936,0.012950089,0.012967037,0.044170227,0.028196367,-0.06381532,0.005883871,-0.008985808,0.03030341,0.02124294,-0.016295984,-0.025911456,-0.014266974,0.05063778,0.012643666,0.012467431,-0.035800014,-0.12888902,-0.056655902,-0.001392723,-0.0698623,-0.021882148,-0.044777337,-0.0087006055,0.018059874,0.25265932,0.004541734 +2.7.7.94,"The mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to the phenolphthiocerol/phthiocerol polyketide synthase.",384,1.0,-0.065597095,-0.048361987,-0.07901298,-0.010496465,-0.002139351,0.020780206,0.031369403,0.04261171,0.043268457,0.02198325,-0.028155677,-0.082669966,-0.0014263167,-0.00010983894,-0.04602788,0.075446144,-0.04780459,0.052563902,-0.041626703,-0.06478138,0.045843303,0.05545561,0.012678119,-0.027124131,0.036332488,-0.012997367,0.05810428,-0.0032342526,-0.028370168,-0.058302853,-0.01350456,-0.08366951,0.018641701,-0.013526677,0.07711008,0.13361621,-0.025711976,-0.12692976,0.10445916,0.0045607113,0.083831586,-0.02608415,-0.028377809,0.010883804,-0.04999733,0.043311037,-0.06703109,0.049604155,-0.004862082,-0.03962147,-0.06546485,0.0017815366,-0.06030371,0.033995803,-0.0010384914,0.11654315,0.05877902,-0.046060476,0.008316616,0.0150065785,0.009778717,-0.026013723,-0.0018187576,0.07050867,-0.045612335,-0.08353984,-0.00537978,-0.0008267079,0.014459509,-0.037067592,-0.10037632,0.0008793277,-0.0058710733,0.03790134,0.072802916,-0.050332274,0.011605605,0.0056549767,-3.11301e-05,-0.008188909,-0.012803494,-0.042991877,-0.0034863355,-0.041650698,0.029266112,-0.06790077,0.11769026,-0.013082941,0.004225923,0.09546997,0.049621604,-0.08840798,0.035180148,-0.08491364,-0.059598632,-0.042202376,0.12156775,-0.034386765,0.017382285,-0.043833997,0.010522439,-0.040309202,0.0029999705,-0.036252044,-0.049680218,-0.00014732328,-0.064215794,0.046533562,0.049719457,0.052352384,-0.04551074,0.05373954,0.009620036,-0.021418508,-0.00024998936,0.09445585,0.019547189,-0.03984021,-0.03971399,0.009331404,-0.034539822,-0.096102834,-0.015765466,0.052616343,-0.115120284,-0.002869918,-0.099673234,2.5021009e-33,0.05190724,-0.01018905,0.008518488,0.01018209,0.0069437684,-0.031085154,-0.11637133,0.001269591,-0.017842922,-0.14579213,-0.022351542,-0.069400474,-0.004966949,0.062345974,-0.070966594,0.041145183,-0.086099274,0.03610485,0.08183954,0.09484237,-0.01455031,-0.015393315,-0.014951098,0.06463823,-0.0057174843,0.08094134,-0.07312351,0.02093003,-0.038460277,0.023688778,0.02831655,-0.03641618,-0.0562768,-0.010406848,0.035109702,0.000324614,0.007924253,-0.114305206,0.06569648,0.015193344,-0.016024763,-0.07656726,0.0071877027,0.005632914,0.044120893,-0.017604282,-0.024364416,0.04784204,-0.031379018,0.08894154,0.0123630185,-0.08421175,0.098412916,-0.03314458,-0.047119383,-0.02251295,-0.067001395,-0.07336408,0.0036723097,0.023970686,0.034338694,0.0733659,-0.010493606,0.08500859,-0.057446525,-0.027608693,-0.00893088,0.009375119,0.0102513395,0.09012552,-0.03828253,0.0018677912,-0.0070055886,0.020928646,0.049634125,-0.0010877297,-0.11170456,-0.04027602,-0.044478104,0.0031761623,0.068004765,0.020915762,-0.016263533,-0.054701276,-0.0017078652,-0.03925796,-0.036964368,-0.05631916,-0.04135154,-0.012712027,0.04948347,-0.078565106,0.006246886,0.09072707,0.01398956,-5.8342437e-33,0.14151737,-0.11535102,0.057761822,-0.07745448,-0.04436961,-0.022486884,0.065999806,0.015795784,-0.0010497565,0.01277998,0.018042827,0.021203384,-0.016923996,-0.037332818,-0.010282298,-0.0337662,0.014507509,0.037641484,-0.034840845,-0.03675759,0.015188257,0.0029387323,0.044772197,-0.01204242,0.0041200574,-0.01930147,-0.116337165,0.08696317,0.031544965,0.029746292,-0.0068723173,0.0034462584,-0.028691087,-0.03552453,-0.024447646,0.010885963,-0.084804766,-0.018319858,0.06413551,0.03126655,0.08978299,0.05249067,-0.031894226,0.008176854,-0.02112699,0.046924584,-0.064496756,0.0134847555,0.03457184,-0.084133886,-0.025372963,0.056645136,0.050558902,0.023062337,-0.002196779,0.11820412,0.050251983,-0.008830704,0.009144956,-0.05273992,-0.09783031,-0.022444367,0.04832776,0.025165595,0.0067519546,0.07817145,0.05506429,0.08841826,0.07041969,-0.013204021,0.052950818,0.03899343,-0.028230818,0.005972644,-0.0750294,-0.047209106,-0.052322958,0.015038331,-0.01385592,0.011356674,0.0045989007,-0.0071812705,-0.0006160162,-0.1144835,-0.021626614,-0.052591022,0.052363954,0.07780074,-0.021832865,0.024573412,0.013994609,0.09249967,-0.016967343,-0.006951837,0.039004423,-3.8494935e-08,0.013040262,-0.07301023,0.05968652,-0.016683912,0.06423813,0.047704145,-0.05219911,-0.035680283,0.026038822,0.0062019075,-0.03615104,0.03894169,0.041945033,0.017045835,0.07956997,0.0667659,-0.043876134,-0.05607681,0.041204154,-0.029187877,-0.0886497,-0.0139712505,-0.025579045,0.09464653,0.034438826,-0.026302926,0.04391544,0.06519959,-0.011298414,0.04918372,0.020926412,0.020319527,-0.07134799,-0.009668003,-0.0524334,0.0133541385,-0.053671937,-0.101265356,-0.017832035,-0.02297791,0.045362256,0.03579525,-0.039270338,0.040800396,0.016931843,0.08375636,-0.005112754,-0.022742102,0.017464716,0.052436236,0.011349979,-0.016018167,-0.036320955,-0.01939948,-0.061765324,0.023772178,-0.01901665,-0.01801337,-0.037124008,-0.0035359585,-0.011212539,0.06454315,0.15408827,-0.058957137 +2.8.3.25,"The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bile acid 7alpha-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. Clostridium scindens possesses two forms of the enzyme, encoded by the baiF and baiK genes. While the enzymes have a broad acceptor specificity and can use allocholate, ursodeoxycholate, and beta-muricholate, the donor specificity is more strict. BaiF acts on lithocholoyl-CoA and deoxycholoyl-CoA, and BaiK acts only on the latter.",384,0.99999994,-0.045572057,-0.08721309,-0.0941484,-0.016599037,0.06477281,-0.002531515,-0.06506285,0.02199644,0.058950376,-0.06685113,0.011554063,-0.06380371,-0.050638534,0.08433756,-0.026487147,-0.032474935,-0.08265561,0.038962938,0.0069616,-0.007470412,-0.01357164,-0.017696578,0.009635652,0.055906806,0.0071620084,-0.00220429,0.079711616,-0.011275147,-0.017446373,-0.093550436,0.013022618,-0.0068138684,0.069293015,-0.04238468,0.041490737,0.08496878,-0.027172921,-0.004884455,0.007392057,-0.016047252,0.03570699,-0.07548221,0.022713987,-0.023778783,-0.089600906,-0.01612064,-0.025750903,0.04058052,0.07463636,-0.027530523,-0.09956569,-0.04317824,-0.11599766,0.08497225,0.054676346,0.00046012798,0.018159619,-0.03952902,-0.00356877,-0.011442499,-0.031993534,-0.019388486,0.017262423,0.00087234116,0.037355315,-0.056150556,-0.002081102,-0.058755122,0.039051168,-0.063065,-0.068537235,-0.05310559,-0.009068448,0.03144429,0.037250094,0.06052284,-0.029886574,0.028759537,-0.026660532,-0.07184353,-0.06621453,-0.0632024,-0.036622193,0.055734687,0.062914945,-0.017344877,0.014654981,0.005187233,0.0009840399,0.029105179,0.075293705,0.08268473,0.014216808,-0.09783815,-0.056938108,0.0770508,0.03337932,0.027026363,0.030492771,-0.05323273,-0.057627823,0.046403088,-0.06271237,-0.08085345,-0.036761325,-0.045855094,0.039224107,0.07811532,0.018838141,-0.09984948,0.035500232,0.004662312,0.08972505,0.030073699,-0.032270532,0.09554372,0.012657424,-0.04872566,-0.05036357,0.022692172,-0.08692954,-0.0023137645,0.049397297,0.011585891,-0.08927094,0.05553798,-0.040273685,3.0695372e-33,0.05172989,0.040991828,-0.020315783,-0.011157793,-0.041715913,-0.058140878,-0.0557665,0.0067529706,-0.020508222,-0.05736156,0.03874458,-0.060761616,0.024419433,0.025147283,-0.0026304421,-0.031060867,-0.0034384404,-0.003235695,0.038791794,0.030140031,0.082975596,0.06898784,-0.0062920516,0.0012659589,0.09945048,0.0397887,0.0016994247,0.053288482,-0.056000136,0.016523834,-0.0450148,-0.04435781,-0.034332436,0.034856927,0.03010031,0.04193654,-0.03533769,-0.013707791,-0.044761788,0.050027486,0.019530756,-0.03051775,-0.05637122,0.008517601,0.035711017,-0.01409658,-0.05417061,0.07417839,0.020614695,0.053565416,0.07561715,-0.029226225,0.05097804,-0.06432086,-0.032129865,0.0136957,0.01508374,-0.017146096,0.005490226,-0.03482683,0.056923382,0.074486226,-0.076164916,0.027479306,0.034506287,-0.0370048,-0.017308872,-0.009587188,-0.031269632,0.07866582,-0.047628578,-0.014663735,0.004556139,0.042058952,0.014751133,-0.026664255,-0.057376284,-0.019490777,0.08770723,0.051647797,-0.019744676,0.018101241,0.019596359,-0.050126728,-0.07475205,-0.004996974,-0.061659522,-0.0042158565,-0.044631157,-0.014751809,-0.029884106,-0.04080429,-0.020060549,0.014297235,0.0051145214,-4.0735916e-33,0.13026321,-0.11899419,0.043539822,-0.051227935,-0.073328726,0.07803436,0.007992346,-0.016719332,0.09817942,-0.023912918,0.076807655,-0.022286588,0.035704747,-0.119210206,-0.029246133,0.010981926,0.015446851,-0.000702496,-0.067360654,-0.038127843,-0.00945083,0.13983077,0.02477132,0.07794857,0.018541768,0.036037166,0.005260393,0.09122628,0.020637268,0.07546376,0.029749509,0.03784673,-0.04017861,-0.048059113,-0.03656461,0.057408042,-0.032997973,0.042629313,0.0017266104,-0.00014496826,-0.011280612,-0.003943129,0.034749072,0.028827652,0.02835816,0.036013003,-0.020993054,-0.011014539,0.01830348,0.013275308,0.06124248,0.02385258,-0.011946479,0.038952712,-0.0057843956,0.0300898,0.004581323,-0.051823836,-0.030245876,-0.13783288,-0.06952867,-0.045194227,0.036099456,0.05093446,0.0039030544,0.04829087,-0.056298275,-0.004896015,0.060104884,-0.112602256,0.040061247,-0.055365928,0.036615342,0.060615573,-0.027153846,0.051999774,-0.025855867,0.0019492034,0.028285304,0.012278749,-0.047060713,0.052648455,-0.03902112,-0.089227006,0.027172495,-0.05750796,-0.056535758,-0.004906165,0.032255225,-0.0003859982,-0.052135557,-0.026911886,-0.0020037836,0.017162353,0.091191694,-4.4110063e-08,0.039128423,-0.07047811,0.015416785,0.029351681,-0.012444544,-0.025282007,-0.06198194,0.005600522,0.043027174,-0.036045153,-0.024756717,0.11104721,0.037371803,0.050009444,0.0011817296,0.008124629,-0.015281618,-0.0288777,-0.03039444,-0.048438538,-0.047934223,-0.060519513,-0.022698827,0.10189876,0.021497749,-0.0009923425,0.02573611,-0.0032287377,-0.018227354,-0.03622642,0.06254677,-0.00094873103,-0.020258095,0.0771023,0.03956611,0.04306628,0.009881365,-0.067170024,0.008195058,0.18066673,0.07515033,-0.027248446,-0.13162787,-0.009672173,-0.060645383,-0.009233018,-0.05375765,0.07059227,-0.03657715,0.06319134,0.066949576,-0.010623261,-0.008075941,-0.011618341,-0.040536616,0.05545887,0.04750074,-0.026068317,0.009116691,-0.046882633,0.082461745,0.0041200207,0.25409043,-0.03454463 +3.1.1.100,"This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green filamentous bacteria (Chloroflexaceae), catalyses the first committed step in the biosynthesis of bacteriochlorophylls c, d, and e, the removal of the C-132-methylcarboxyl group from chlorophyllide a. The reaction is very similar to the conversion of pheophorbide a to pyropheophorbide a during chlorophyll a degradation, which is catalysed by EC 3.1.1.82, pheophorbidase.",384,0.99999994,-0.06684042,0.056847323,-0.08742799,-0.058395915,0.049448304,0.09914496,-0.08006643,0.010438858,0.091376245,0.023342336,0.0039833463,-0.03905631,-0.09895834,-0.0112198,-0.008539671,0.069550805,-0.15112507,0.019216968,-0.03157614,-0.06524643,0.031390425,0.02511341,-0.06362645,-0.014892023,0.032184113,0.033923235,-0.007554213,-0.03630393,-0.03655586,-0.06532599,-0.03126333,0.004137843,0.05038384,-0.024086203,0.075153254,0.097314395,-0.048124097,-0.10684322,0.04880607,0.013013152,-0.023042446,0.046908878,-0.06592368,-0.031365216,-0.0775877,0.050970066,-0.007978328,0.051716853,0.018287873,-0.09986664,-0.0051410445,0.0116538005,-0.026928708,0.041409098,-0.025231345,-0.0002836186,0.02593807,-0.03573842,0.050827675,-0.034830544,-0.008154672,0.030772127,0.051380705,0.014957131,-0.02914828,-0.06229328,0.024171801,-0.112440184,0.046389967,-0.06132289,-0.110766195,-0.072929636,0.003931261,0.032329123,0.03256849,-0.0044979323,0.04842232,-0.023705695,-0.010858205,0.0020874154,0.017813016,0.012152582,-0.0542773,0.056268074,0.062410966,0.005292198,-0.042850222,-0.013764241,0.083829336,0.028045755,0.051788438,-0.027813425,0.0014588771,-0.025287421,-0.04662522,0.10519937,-0.028609456,-0.0317117,0.008522799,-0.0555928,-0.0042108498,0.023515679,-0.11023342,-0.15076202,-0.054768436,0.020753609,-0.0018664709,0.11145726,0.034589898,-0.017287385,-0.034141827,-0.02425523,0.004807005,-0.03184695,0.0010121451,0.09881618,0.055646338,-0.012004444,-0.069714785,-0.008979672,0.027080704,-0.06666506,-0.023351837,0.0592219,-0.071183465,0.027315868,-0.15102021,3.7770782e-33,0.11322787,0.06307768,0.022338713,-0.05069247,-0.015040094,-0.021131903,-0.054429427,0.061710715,-0.002198668,-0.10114977,-0.013110735,-0.10609181,-0.02126157,-0.048364617,-0.045044523,-0.02883031,-0.02686039,0.0392351,0.015295966,-0.04660155,0.0030017777,0.06235222,-0.028769115,0.043309662,0.035960115,0.102726616,0.00072984427,0.013618692,0.11224602,-0.019435383,0.06950006,-0.041257966,-0.07215126,0.03870975,0.047229797,-0.022217179,-0.05155297,-0.025538491,0.0035475567,0.103357576,-0.061221622,0.033016432,-0.015336033,-0.0053624795,0.0672264,-0.052452564,-0.07545265,0.049336337,0.07455671,0.05030131,-0.03401906,0.031132916,0.13240024,0.026045501,-0.06727246,0.026753023,-0.012950557,-0.08468084,0.004304802,0.04304828,0.045367837,0.10918645,-0.0013755404,-0.015278673,0.0003173434,-0.039348323,-0.019573025,-0.01584103,-0.049710266,0.053113572,-0.08640508,-0.049633365,0.015827103,0.0218879,0.103893444,-0.03601603,-0.032132484,-0.047980096,-0.00460931,-0.018210258,-0.011038506,0.026421012,0.03717123,-0.05952699,-0.02899525,-0.03113647,-0.056099925,-0.07948802,0.012766443,0.042291403,-0.016079055,-0.101048395,-0.046125464,0.051357694,-0.04679669,-5.248978e-33,0.060077116,-0.08610481,0.046527084,-0.074197695,-0.031766683,-0.021333354,-0.038254,-0.014565455,-0.048697304,0.027245915,0.029374162,0.02349995,-0.016837396,0.008506388,0.0517146,-0.005496848,0.10371248,0.086905375,-0.043732043,0.059013747,0.042450447,0.03721382,0.03594308,0.022996927,0.030002763,0.007269736,0.026973095,0.027791448,0.1011728,-0.034892213,-0.02069851,0.009129809,-0.036873646,-0.018396707,-0.026757633,0.040834866,-0.055533774,0.012876401,0.027972884,0.064703695,0.04808143,-0.00088864396,-0.029627625,0.012397431,0.0034131682,0.017972572,-0.062348776,0.058919776,0.06894048,-0.007133432,0.037850503,0.09356256,0.03486806,-0.017233968,0.03894555,0.009560388,0.019964475,-0.0066614673,-0.006246914,-0.020360693,-0.023319291,-0.0713346,0.008392017,0.035885695,0.044731677,0.06280828,0.010794064,0.095680416,0.04483046,-0.046334166,0.018663852,0.0467291,0.015045956,0.011207207,-0.060486108,-0.045605842,-0.008734564,-0.08175622,0.023047458,0.008922442,-0.0065177213,0.005728136,0.06847879,-0.10072837,-0.010802724,-0.071603656,0.006303458,0.04805437,-0.018187584,0.01943869,-0.031192372,0.0020884366,0.072835214,0.0931362,0.035926767,-3.935503e-08,0.008383902,-0.03667692,0.03920841,-0.021153145,0.030838756,0.014734821,-0.028758418,-0.0114799235,0.024097858,-0.04995892,-0.062732376,0.053448536,0.088444285,-0.002830681,0.0483543,0.011011996,-0.031864446,-0.02746975,0.041927055,0.03172335,-0.0514702,-0.0308228,-0.11986086,0.067548506,0.014395984,-0.016562207,0.045970183,0.0062333713,-0.017123962,0.032300796,-0.002761316,0.033304688,0.022410478,-0.006729616,0.003004414,-0.022813682,-0.09438838,-0.050226934,-0.082858905,0.023218803,0.030242333,0.06352565,-0.06792462,0.057941895,0.0353926,-0.0123750055,-0.0028786005,0.017781168,-0.033928823,0.013803816,0.08595399,-0.029583223,-0.016298143,-0.055827055,-0.08980481,-0.049596954,0.029837038,-0.07783056,-0.03551336,-0.024203124,0.029639758,-0.017787637,0.14292523,0.05544595 +3.1.1.101,"The enzyme, isolated from the bacterium Ideonella sakaiensis, also produces small amounts of terephthalate (cf. EC 3.1.1.102, mono(ethylene terephthalate) hydrolase). The reaction takes place on PET-film placed in solution.",384,0.99999994,-0.068440765,-0.002566648,-0.06882402,-0.019913036,0.06870421,-0.004528772,0.02301596,0.04824856,0.043006826,-0.007915203,-0.0010200719,-0.07328439,-0.08473714,0.006098932,-0.023408903,0.008954846,-0.01588974,-0.04392639,0.0003970149,-0.06904881,0.06940217,0.052868813,-0.0005588363,-0.018588133,0.04452443,0.0038285267,0.10902527,-0.04722601,0.026315682,-0.031838257,-0.003547339,-0.03418864,-0.03334016,-0.057389386,0.06607254,0.05173746,-0.09085321,-0.027166706,0.059910793,-0.036652826,0.060877588,-0.0097600985,-0.017654642,-0.06397146,-0.10914094,-0.019083926,-0.037820183,0.023577027,-0.00261352,-0.082637765,-0.06497596,-0.029796178,-0.084511794,-0.008367703,-0.034860402,-0.1185871,0.026759531,-0.06231113,-0.08978372,0.0074571464,0.052136853,0.019944396,-0.0055202255,0.013741759,0.021415645,-0.03184367,0.0070384294,0.0063485666,0.036298234,-0.08005187,-0.048998512,-0.0272993,0.06980227,0.06734902,-0.061297067,-0.06648618,0.04709285,-0.039929673,0.070492245,0.023696683,0.013585053,0.037853602,0.04880304,0.10206272,0.0041778404,0.011008451,-0.018295433,0.10118009,0.011115211,0.013976257,0.04625813,-0.0017303143,-0.07541508,-0.06483855,-0.014514593,0.025245115,-0.013394045,0.027623162,0.09267549,-0.032635856,-0.051647156,0.06305353,-0.014454366,-0.115314946,-0.107932396,0.027285678,0.066382326,0.074696615,0.0942813,0.031211644,-0.06429719,-0.019844165,0.034826227,0.030075755,-0.015102979,0.031132301,0.034778483,-0.079752184,-0.07784603,0.020888735,0.030387433,-0.06705841,0.038185194,0.08915578,-0.058819145,0.08329043,-0.102203116,8.406998e-34,0.08471712,0.034156006,-0.040457457,-0.07009563,0.01708029,0.019365467,-0.021315692,0.020307949,-0.10982576,0.038996592,-0.070105575,-0.05854414,-0.009101374,-0.00520611,-0.020496003,-0.07109924,0.01428068,0.089019686,0.02739661,-0.039142095,-0.023216356,0.049144045,-0.031884,0.043828055,0.0069448496,0.034131806,-0.026711812,0.016025437,0.007361736,-0.01168588,0.047422275,-0.060914155,-0.10204649,0.004787562,0.029811015,-0.025061399,-0.09815456,0.0075827427,0.012322957,0.060594633,0.03992045,0.08985172,0.04224832,-0.042974938,0.035314497,-0.056660853,-0.105165735,0.10426345,0.021569885,0.023325786,0.035234164,-0.012785927,0.086732365,-0.06364783,-0.03321381,-0.0061459388,0.027192421,-0.03937421,0.060193207,0.038889036,-0.020860689,0.07917963,-0.10262015,-0.0037973453,-0.021246633,0.05159637,-0.048442878,0.019874014,-0.01615549,0.06140101,-0.033366863,-0.01720074,0.04413208,-0.06366923,0.039798487,-0.040662833,-0.028561275,0.007968031,0.011980395,-0.01988141,0.010984991,0.030173631,0.018264186,-0.03846155,-0.021389164,0.002761209,-0.06403437,0.07592952,-0.007911014,0.067865714,0.08249919,-0.077724114,-0.098206334,-0.017330425,-0.040966474,-2.0693663e-33,0.08341526,-0.03921623,-0.052291617,-0.14630534,-0.025088513,0.09567572,0.047000635,0.057037912,0.007164451,0.016513696,0.093709685,0.021724997,0.074232705,-0.028926536,-0.025690291,0.0024448298,0.053456012,0.0817642,0.011882023,-0.070691586,-0.005365844,0.040398527,0.008251351,0.0020716323,-0.0074523697,-0.014685619,-0.009936313,0.12731327,0.0043680086,0.020658277,0.029878378,-0.07727951,-0.0214016,-0.026444763,-0.01580466,-0.03402573,0.027415587,-0.044458248,0.0049883923,0.0098654665,0.020588612,0.02267354,0.014737815,0.12773007,0.029732201,0.037097488,-0.06704612,-0.038595002,0.0049416884,-0.06147456,0.013279081,-0.047428597,-0.005111023,-0.048859857,-0.0060300543,0.059545055,0.016054789,-0.008281219,-0.035700757,-0.06002282,-0.009175369,-0.0616654,0.005494445,0.02009109,0.019841824,0.081897795,-0.0203475,0.05668703,0.04173819,0.004449218,0.059503123,0.05535719,-0.03056145,-0.040814813,-0.045916975,-0.018642884,-0.012953134,-0.0401762,0.044890944,-0.023280254,0.079887,-0.003910828,0.0035730638,-0.098753326,0.042351753,-0.036671724,0.060562294,0.07957683,-0.031096507,0.022491915,-0.039247755,0.04623704,-0.024319464,0.09364301,0.116117746,-3.879153e-08,-0.03041362,-0.091227874,0.03740533,0.006191417,-0.012212052,0.056384936,0.017949093,-0.02796914,0.046802968,-0.034233898,-0.050385825,0.017888796,0.011342758,0.016246814,0.0753718,-0.022871582,-0.009551487,0.0126275625,-0.026349945,-0.06451789,-0.0066456976,-0.0007940521,-0.010664551,0.027958104,-0.011305908,-0.030581499,0.0053829583,-0.06213846,-0.014564651,-0.035028573,-0.11634018,0.080574766,-0.072757244,0.030887077,0.010579512,0.03435941,-0.043374006,-0.02674008,-0.027320014,-0.013554282,0.036588192,0.012195613,-0.07642051,0.00582222,0.07614294,0.039955933,0.011933407,-0.049905643,-0.028636329,-0.029604105,0.081568435,0.0022884882,0.03147028,0.0065988377,-0.03477947,0.005074401,-0.05935127,-0.058965378,-0.027779508,0.010138642,0.086334504,0.07098586,0.18922597,-0.007554726 +3.1.1.102,"The enzyme, isolated from the bacterium Ideonella sakaiensis, has no activity with poly(ethylene terephthalate) PET (cf. EC 3.1.1.101, poly(ethylene terephthalate) hydrolase).",384,1.0,-0.020891277,-0.082193635,-0.030790692,-0.027365057,0.04049309,0.0059522125,0.0063446905,-0.01576979,0.004365234,-0.03354311,-0.02490573,-0.010456255,-0.0943611,0.044416793,-0.00945784,0.056624565,-0.051166885,-0.022138696,0.030211765,-0.027681515,0.02372545,-0.041877422,0.027290436,-0.0143709,0.023565417,0.013658739,0.13728715,-0.062180698,-0.023313703,-0.039183956,-0.028987788,-0.0075320243,-0.032927245,-0.044886973,0.09125558,0.07390216,-0.035226136,-0.038168173,0.018184142,0.0043072687,0.07628133,-0.0012961313,0.016996745,-0.055247318,-0.10248122,-0.012882114,-0.087532915,-0.07242152,3.9181527e-05,-0.059917495,-0.056549497,-0.042466767,-0.037951633,-0.039099567,-0.055467173,-0.105741754,-0.012857416,-0.030319648,-0.09532308,-0.0019250863,0.06488691,0.022299046,0.057516564,0.04599532,-0.0130033605,-0.0027821762,0.009721067,-0.0030539087,0.0044741137,-0.058050897,-0.02949849,-0.02855065,0.0238118,0.045982003,-0.062298797,-0.06723971,0.046657432,-0.054583523,0.076501526,-0.010024758,-0.04675833,0.02434805,0.04178734,0.10056536,0.039821625,0.07364412,-0.019602338,0.105337605,-0.009670929,0.024087595,0.051675193,0.016718274,-0.07203692,-0.07202312,0.025113199,-0.00041824294,-0.028124226,0.0022374613,0.013526484,-0.0092114415,-0.049772047,0.09391868,-0.049559493,-0.1083834,-0.06581594,0.00049676496,0.05108518,0.018731035,0.050185975,0.021856017,-0.061731372,-0.015361845,0.057515573,0.0033704774,-0.038885783,0.007115657,0.024011122,-0.09068155,-0.057601113,-0.011000164,0.018303,-0.1160749,0.04375186,0.08996956,-0.05601787,0.03411113,-0.119710304,8.957885e-34,0.057786234,-0.02169947,-0.007183117,-0.07562201,0.04507565,0.02978641,0.009480711,0.048108157,-0.13312805,-0.017654978,-0.091096275,-0.0055589415,0.036013383,-0.029991036,0.056755252,0.009838794,0.06784068,0.03707742,0.09144992,-0.04760281,0.040616263,0.025092522,-0.03159277,0.030166121,0.023206476,0.006731947,-0.01738725,-0.0123458365,-0.00638879,-0.026735708,-0.00075783674,-0.11722053,-0.06807791,0.10649187,-0.00026067134,-0.011717723,-0.08423047,-0.04614844,-0.0045992285,0.073788576,0.055006497,0.07152367,0.10778058,-0.0569556,0.006034155,-0.03425079,-0.059730582,0.078008905,-0.017523384,0.07436593,0.043120477,0.02844707,0.077016585,-0.082102954,-0.05932314,-0.02703508,0.005597357,0.011563331,0.00028870735,0.04370489,0.0020211283,0.031162241,-0.08345329,-0.06060738,0.02623552,0.043640103,-0.05915465,0.036038212,-0.0007874512,0.066879444,0.00082433585,-0.040070444,0.02077215,-0.03352527,0.07002556,-0.03887961,-0.08644663,-0.0009703249,0.028802805,0.009935984,0.016027577,0.006385759,0.047227252,0.008821809,-0.039355602,0.037599705,0.035477623,0.12940322,-0.027877228,0.04714517,0.10036514,-0.080562785,-0.06925076,0.017926255,0.0008429531,-2.6336284e-33,0.025361257,-0.040668227,-0.028352434,-0.11676618,-0.05304524,0.08764997,0.06817762,0.01127299,0.028325943,-0.022197613,0.1460618,0.0078203725,0.0486443,-0.026850037,0.021326965,0.048778173,-0.045695722,0.06663132,-0.022423493,-0.05181057,-0.07197724,0.05002172,-0.017521217,0.024928836,-0.016573196,0.014131027,0.0014595643,0.099931315,-0.03033398,-0.010524761,0.02538024,0.024201479,-0.05986514,0.0010443246,-0.016822012,-0.031454615,-0.010188596,-0.074269645,-0.024457052,0.009334266,-0.00085190265,0.05060826,0.0054997085,0.11516695,0.009592198,0.04958365,-0.06097786,-0.0047771414,0.006083238,-0.019097513,-0.03368192,-0.0626948,-0.0019824754,-0.035360556,0.0465014,0.087053604,0.008740333,-0.004034277,-0.1010667,-0.09096412,-0.010341153,-0.008146269,0.009628571,0.09554164,-0.0054154363,0.08882922,-0.015911404,0.025757713,0.0185337,-0.047850564,0.077934146,0.08132912,-0.060216725,0.0014221901,-0.06733368,0.01409646,0.009429724,-0.04871441,0.01749022,-0.040430862,0.068160184,-0.02065947,-0.047980048,-0.066214174,0.039496195,-0.025583362,0.024913104,0.050939865,-0.03032793,-0.0049764886,0.03376734,0.047891106,-0.037120145,0.09111002,0.06816215,-3.510845e-08,-0.048345078,-0.070424974,0.013352174,-0.03894689,0.010740262,0.029620646,0.038544707,-0.045976233,0.035723478,0.014726852,-0.021035923,-0.03338241,-0.02565392,0.0034413717,0.083957665,-0.02630668,0.039521284,0.016097514,-0.013332942,-0.01509616,-0.05123606,0.017493866,-0.07711231,0.016814878,-0.024664931,-0.02446652,0.037825476,-0.032105893,0.0030295127,-0.0115473,-0.11425687,0.03881824,-0.010139617,0.021562427,0.014725083,0.039411493,0.060878616,-0.05557377,-0.042321038,0.025289353,0.10521584,-0.008057364,-0.060639694,-0.003135236,0.086752824,0.007283625,0.0021919247,-0.0737009,0.029444225,-0.024308017,0.09588629,0.020102624,0.015274,-0.043243315,-0.029270109,0.027281852,-0.08591604,-0.050869048,-0.011522881,0.02183274,0.09709895,0.027500335,0.1645403,-0.0037217236 +3.1.2.32,"The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the production of the signal molecule 2-heptyl-4(1H)-quinolone (HHQ).",384,1.0,-0.039997287,-0.0034539045,-0.075948015,-0.08242604,-0.008208176,0.05159575,-0.014647976,0.08050958,0.022241946,0.06339794,0.045489118,-0.07445253,0.008309982,0.102098554,-0.046748135,0.070498645,-0.0497677,-0.08266525,0.01802327,-0.043560073,0.06888776,0.041343585,-0.07553509,-0.017203866,0.04705126,0.031389255,0.057321064,0.07548636,0.0010889915,0.03605568,-0.04982319,-0.07440081,0.0843496,-0.0619616,0.06515924,0.045913097,0.008698498,-9.6378455e-05,0.14112186,0.058572195,0.05353294,0.0018912851,-0.023968318,0.006777392,0.053749584,0.03535287,0.030931791,0.081360444,0.035202462,-0.0021098384,-0.042687614,0.0051326435,0.01850444,0.06158158,0.034387797,0.04887966,-0.07107754,-0.043305036,-0.034170773,-0.0018792816,0.0032234024,0.021673035,0.008799007,0.00597387,0.010401459,-0.02877575,0.049600005,-0.010527326,0.038753405,-0.030321712,-0.054267853,-0.011875007,0.018063717,-0.009506589,0.05557628,-0.10905386,-0.04659558,-0.014914172,0.0366563,-0.014956943,0.04661784,-0.07188134,-0.019385962,0.09756478,0.0029143607,-0.00063523423,0.039760944,-0.011213818,0.066394076,-0.013565378,-0.018336423,-0.1012702,-0.041319456,-0.13895857,-0.07135605,0.050201368,-0.06679941,0.012265115,0.07460576,-0.0037897972,-0.005203088,-0.019672709,-0.042582583,-0.08107031,-0.057887424,0.049139567,0.047357682,0.13052703,0.055935014,0.02530694,0.0026879662,-0.0019758185,0.022940595,-0.009865489,-0.007710448,0.096581616,0.0349371,-0.02815811,-0.06517626,0.01761704,-0.014764965,-0.023225484,0.054558534,0.03555088,0.012028565,-0.006375333,-0.059711292,-1.2882349e-33,0.056081727,0.05573962,0.011571882,-0.03846226,0.025182134,-0.0018282884,-0.07107491,0.011247914,-0.07127884,-0.02974009,-0.06377563,-0.088301785,0.009396306,0.055155355,-0.037948508,0.034741037,-0.038536485,-0.04315316,0.043963652,-0.00050172134,-0.028024046,0.044603743,-0.021475187,0.017213576,0.05710073,0.048717234,0.05833316,0.028992567,-0.0074902186,-0.017001502,-0.022357926,0.02483907,-0.03122179,-0.040838864,0.032844815,-0.03418357,-0.048365258,-0.019816238,0.01341111,0.03409433,0.022608275,0.05195746,0.011073925,-0.08406492,0.043026224,-0.046341885,-0.020195799,0.07064665,0.046837,0.037899606,0.052959338,-0.038621236,0.057667565,-0.036404442,-0.0797721,-0.015296343,0.006282858,-0.031367503,0.05043823,0.0035648993,-0.010303241,0.016746625,-0.053892545,0.033090867,0.023243004,-0.020884218,-0.018233012,-0.10753102,0.023892151,0.095870115,-0.033818047,-0.05651414,0.013649271,-0.019722674,0.027931297,-0.05053092,-0.11264724,0.029937841,0.019687396,-0.014240833,0.021699263,-0.07185287,0.04040671,-0.015424595,-0.05723085,-0.03567909,0.053517353,-0.088095896,0.007283726,0.020554064,0.017394762,-0.045112744,-0.049863994,0.013443702,0.018785052,-4.7067767e-34,0.038075726,-0.06751334,-0.033739068,-0.024337739,-0.059516367,0.079958566,-0.007948588,0.032586616,0.052842546,0.0009119318,0.093906164,-0.040464237,0.01218869,-0.006163029,0.026445469,0.006681172,0.0461472,0.0033527096,-0.016367078,-0.021421922,0.03506377,-0.023147622,0.0017770976,0.022207126,0.07895394,0.040673245,0.0043723923,0.11865802,0.07612646,0.10047661,-0.087051705,-0.01613094,0.0025791386,-0.00507366,-0.008786268,0.08252611,-0.009368976,0.033745266,-0.0034811646,-0.0286141,0.043501288,-0.013131812,0.04046739,0.08241673,-0.082256034,0.07691308,-0.03495392,0.05822201,-0.0604326,-0.122746214,0.015787778,0.041947257,-0.0061017135,-0.0007477298,-0.028685719,0.073738635,-0.089559734,-0.021012686,-0.01557561,-0.036385637,-0.039707392,-0.09578989,-0.02594228,-0.046857636,0.028919777,0.03221844,-0.025894273,0.026042702,0.06705223,-0.052463368,0.028469188,0.008879559,0.04406415,0.020212866,-0.08371872,-0.030829597,-0.11793768,-0.117256634,0.025480824,0.04633881,0.021653669,-0.033975173,-0.045493793,-0.038674884,-0.070756175,-0.091133624,0.036938358,0.13873628,-0.038001113,0.030498365,0.04132505,0.09732922,-0.049155697,0.030149242,0.002697447,-3.116732e-08,0.030209022,-0.080287255,0.058660135,0.00088080164,-0.06460499,0.04288511,0.004482087,0.020551825,0.051602457,-0.0159802,0.01731109,0.038602695,-0.046602827,0.0007363284,0.049745563,0.030041715,-0.1093608,-0.025304254,-0.053481873,-0.04108863,-0.06553147,-0.016452575,-0.11874233,-0.028351951,-0.036462247,-0.039079368,0.034161504,0.05628832,-0.039647616,-0.0242506,-0.019434717,0.008885207,-0.008501926,-0.0026884244,-0.1262311,0.027251303,-0.06474853,-0.012883034,0.020958483,-0.029210746,0.06747245,0.024666943,-0.15410404,0.04265649,0.0024772235,-0.00553097,-0.011999867,-0.0051012672,-0.018964078,-0.08062113,0.052240625,0.010830613,0.061055154,-0.05644687,-0.101195976,0.021815255,-0.019921256,-0.08866215,-0.033819806,-0.020742176,0.04056482,0.03038405,0.16249038,0.041231267 +3.1.3.103,"The enzyme, characterized from the bacterium Bacteroides thetaiotaomicron, is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.",384,1.0,-0.06802959,-0.09342933,-0.07077816,-0.043884944,-0.016934417,0.069598496,-0.01933529,-0.019038366,0.037732292,0.011719367,0.055152446,-0.021316726,-0.041634433,0.035527226,-0.09057807,0.0048176246,-0.049940035,-0.015896676,-0.022579046,0.022210801,0.0628973,0.036463533,0.031363256,-0.003376383,0.06312975,0.0013911267,0.03194693,-0.039480314,-0.006099394,-0.034624994,-0.03272004,-0.042803627,0.08329307,-0.062184103,0.067751385,0.04717922,-0.017187433,-0.01300755,0.064638786,0.021052524,0.03829824,0.016420454,0.018444149,-0.028757207,-0.027621176,0.004566227,-0.035715725,-0.0009178306,0.07057712,0.0022228605,-0.018415142,-0.07970781,-0.034484405,0.0151454285,0.06907546,0.061768323,-0.1032164,-0.07308884,0.042103413,0.014171955,0.09183972,0.03233416,0.038993545,0.037791774,-0.01174026,-0.029449146,0.06936751,-0.026773915,-0.004913255,-0.03516949,0.018532142,-0.07209142,-0.05576448,0.0054202178,-0.023084387,0.010917069,-0.02728958,-0.04041168,-0.017342247,-0.03547562,0.04384611,0.035351403,-0.015287406,0.047814596,-0.05095073,-0.055884432,0.018727839,0.02215721,-0.029484093,-0.03003229,0.008224722,-0.04151316,0.0006598352,-0.12972952,-0.06681317,0.048194,0.050340224,0.04219335,0.025684647,-0.012236877,-0.05910458,0.0199553,0.010796152,-0.0980436,-0.059108812,-0.0033267776,0.01152013,0.050085697,0.08214287,-0.041450467,-0.025629494,0.06607464,-0.031993445,0.039561976,-0.008714174,0.013881479,0.06669702,-0.118108615,-0.050672255,0.04427877,0.014132247,-0.09673712,0.04733627,0.07562504,-0.021672104,0.07474611,-0.0869438,2.3247034e-33,0.13169822,-0.027902523,0.04216081,-0.0799479,0.061710667,-0.041400228,-0.11007046,-0.033868395,-0.06837566,-0.078913115,-0.11231481,-0.067859605,0.0372642,0.067184046,0.009091805,0.09272262,-0.009327927,-0.013598162,0.10095205,-0.0023747473,0.059853148,0.030943748,-0.019469352,-0.022073071,0.020640014,0.04843836,-0.01320856,0.03750463,0.045070354,0.006554497,0.06881712,-0.1310283,-0.08500003,0.035091538,0.047322318,0.0028859542,-0.08223568,-0.035108984,-0.013603691,0.08554506,-0.0005087824,-0.008496935,0.0037518106,0.027986458,0.012501965,0.0019530159,-0.009016944,0.032173138,0.045180812,0.07955173,0.012254482,-0.006083471,0.07810939,-0.022437453,-0.024124559,0.07131349,0.048134167,-0.0047255293,-0.027311122,0.04811659,-0.0010781251,0.015279805,-0.0543135,0.07141362,0.042769603,0.012197749,-0.07869096,0.012658059,0.04334226,-0.045706928,-0.06872953,-0.027413167,-0.008099612,0.031800184,-0.0070379707,-0.037656654,-0.0017761798,-0.03886917,-0.0037516195,0.004642246,-0.056017384,0.012687611,-0.04166848,-0.043702994,-0.050862864,0.017003167,-0.055240765,-0.06389391,0.016380968,0.027894542,-0.04813471,-0.042301323,-0.09118782,0.005787887,-0.031494107,-4.9799837e-33,0.07673327,-0.08041641,0.053603977,-0.055192538,-0.020260554,0.120786354,0.0387447,0.09711536,-0.017190715,0.00543414,0.07314998,0.019176599,0.009293124,-0.02936346,0.05272313,0.05037478,0.031132862,0.07165449,-0.0058588847,-0.06500044,0.01852726,0.020259095,-0.00767108,0.00852611,0.025983268,0.026278319,-0.028784962,0.075278826,-0.04115927,0.08677204,-0.010523867,0.024016453,-0.094094336,-0.05886279,-0.035281528,0.03551815,-0.036619943,-0.0265252,-0.015155138,-0.015795521,0.024711942,0.08073253,0.030558145,0.068357766,0.04534861,0.064686365,-0.053106587,0.006816921,0.035755698,-0.03764295,0.022167997,-0.032531515,0.06727839,0.047387533,0.049798694,0.043168418,0.034182753,0.14607796,-0.013908082,-0.079992756,-0.044959087,-0.11446287,0.055003043,-0.0350355,0.04637203,0.05317028,-0.008695627,0.04458261,0.018192336,-0.056720078,-0.00048145783,-0.05267261,-0.027150199,0.043710448,-0.096523896,-0.016349653,-0.07779911,-0.034516685,0.023408862,0.019614082,0.07568179,0.018035403,-0.061636776,-0.061656453,0.021200359,-0.01407054,0.05834188,0.11074389,0.023422912,0.015993144,-0.05813135,0.013206223,-0.12445813,0.03319936,0.029877756,-4.415509e-08,0.04714344,-0.07347139,0.010909586,-0.074755974,0.020241791,0.0065294085,-0.011672423,-0.0029015744,0.02117724,-0.08049676,0.024169395,0.082977,-0.027651656,-0.024254644,0.014229852,0.050914016,-0.033666857,0.0008645924,-0.03122223,0.03551521,-0.09007431,0.02699132,-0.08853997,0.049267728,-0.029928269,-0.051978745,0.018110145,0.06411839,-0.0023565993,-0.01271199,0.023549905,0.001065217,-0.08256897,-0.022050347,-0.07232363,-0.0029783368,-0.083680764,-0.050793942,0.044699892,0.014487525,-0.00943354,0.0024288124,-0.047108818,0.035219252,-0.04418955,0.012861461,-0.010678119,0.07384974,-0.04815843,0.0062886104,-0.02200896,-0.09294962,-0.034896974,-0.053374838,-0.15443678,-0.007676718,0.026229553,-0.089413926,-0.02504318,0.0038907481,0.002030973,0.028803349,0.17236605,0.01880409 +3.1.3.104,"Requires Mg2+. The enzyme, which is found in plants and bacteria, is part of a pathway for riboflavin biosynthesis. Most forms of the enzyme has a broad substrate specificity [1,3].",384,1.0,-0.03127125,-0.081191465,-0.04140013,0.018259974,0.07342533,0.023684874,-0.08628947,0.0033131903,-0.012787443,0.006417786,0.0042194305,-0.0225913,0.006902802,0.015455755,-0.016546782,-0.01856647,-0.04525642,0.045602534,0.013311594,-0.019096334,0.07960373,0.050451092,0.001454134,-0.031964764,0.02037851,-0.01733001,0.045861624,-0.048884448,0.05041973,0.011886873,-0.012591855,0.040763155,0.078969665,-0.08796177,0.024625478,0.124993384,-0.029857054,-0.04970782,-0.00042865513,-0.016019283,-0.0049376367,0.0035806985,0.0714269,-0.01672919,0.03349258,-0.059758916,0.06162216,-0.004889694,0.025137007,0.032126077,-0.08336204,-0.019466432,-0.061863605,-0.058670484,0.057896502,-0.030983487,-0.008676281,-0.0034297989,-0.008466821,0.0100751035,0.02023711,-0.032172844,-0.06074152,-0.024946446,0.044448998,-0.013982093,0.0073473547,-0.040416397,0.024757497,-0.042794824,-0.0010945756,-0.07419367,-0.058904123,0.048876323,-0.09596115,0.055906348,0.03712091,-0.055455,0.03334222,-0.005553026,0.0023247388,0.012795533,0.06644542,0.04732095,0.027797936,0.031916153,0.04218687,0.072062545,-0.003380696,0.106118,0.09263559,0.022282893,0.013945503,-0.022969633,0.012312746,0.06912285,-0.015267194,-0.013417929,0.03316566,-0.039961446,-0.020970898,0.055878405,-0.0068525495,0.014398736,-0.052501753,0.07162233,-0.05790958,0.030549996,-0.0040664705,0.045297764,0.06825279,0.024086423,-0.026090143,0.0229499,0.04791123,0.045251597,0.04772017,-0.124748826,-0.057011437,0.05200986,-0.034409337,0.015620895,0.04452432,0.07695759,-0.0431203,0.015926696,-0.080620535,-1.7685417e-33,0.014769809,0.00031296237,0.026696533,-0.022025065,-0.04001269,0.03194102,-0.083543524,0.006446548,0.0125528155,-0.011937085,-0.1268254,-0.113760635,0.0034448297,0.0037162374,0.00014910872,-0.050972536,0.020939792,-0.043485727,0.071808554,0.057294246,-0.05370279,0.0434151,-0.011597752,0.009256579,0.01998858,0.1059026,0.084012255,-0.091747336,0.044850633,-0.03251412,0.031893663,-0.15030274,-0.049214173,0.07597966,0.048350878,-0.027923388,-0.020794872,-0.018684758,-0.019672478,0.047623448,0.010435693,-0.009037757,-0.022801932,0.02049429,0.08116908,-0.04329583,-0.0148339635,0.03227991,-0.014081399,0.070542976,0.07619783,0.047200687,0.043353822,-0.0065306253,-0.06419032,0.032609534,-0.029282609,0.043721583,0.09561788,0.021726768,-0.01782153,-0.0032114345,0.032201525,0.07345763,0.037389606,0.04514463,-0.11414854,-0.084393404,-0.024490848,0.06643151,-0.00019496903,-0.094579995,0.0456227,0.028372949,0.026881551,-0.021996686,-0.048958573,0.034573548,0.03701112,0.018148005,-0.042609747,0.023922147,-0.017424678,-0.015878577,-0.085264325,0.005713715,-0.043762676,-0.09688032,-0.025979305,0.010135196,0.043629065,-0.025105318,-0.055722132,0.0683329,0.046676274,-8.35225e-34,0.0925761,-0.07226691,0.10797642,-0.07558687,-0.11016917,0.038906757,-0.013794735,-0.16366428,0.0628067,0.029658409,0.04405432,0.03089178,-0.0041139727,-0.06586876,-0.026101505,-0.009862399,0.006969243,0.098761976,-0.05011457,-0.022511823,-0.032826427,0.07590822,0.019688724,0.015326146,0.034685973,0.030017428,-0.007322944,-0.0007463644,0.02601171,0.08708517,-0.037276696,0.067198984,-0.05133838,-0.042490933,-0.04252954,0.084816575,-0.032874085,0.0073315613,-0.011169719,0.100243054,-0.035453618,0.114448115,0.032791946,0.06581496,0.012021426,0.029816445,0.0077179857,0.019972198,0.021276105,-0.09059363,0.035157863,-0.020173691,-0.010205942,-0.008058162,0.032604367,0.02713041,-0.012648021,0.020147106,0.040934023,-0.036192376,-0.0063874614,-0.040611435,0.03286104,-0.050061606,0.011445324,0.06715649,0.022308089,0.033056416,0.009531303,0.009467291,0.037037298,0.034193628,0.07929883,0.071371056,-0.015804226,0.06770571,-0.03406206,-0.06419778,-0.01550512,-0.10084477,0.011952868,0.07041582,-0.04261765,-0.027737724,-0.013710062,-0.17569129,0.011333846,0.056629907,0.027734278,-0.00796607,-0.07255719,-0.023393415,-0.053298485,0.026785918,0.050302334,-3.3072578e-08,-0.043303333,-0.029488975,0.025335755,-0.093322426,0.035909157,0.0643077,-0.02968379,-0.046370752,0.09372328,-0.018796436,-0.028196506,-0.0031767243,-0.0733359,0.006228595,0.030922877,-0.015003015,-0.05412157,-0.023743283,-0.047354713,-0.006450888,-0.009851106,-0.04687106,-0.15669462,0.049260188,-0.02217617,-0.113290824,-0.06123431,0.03756402,0.014183445,-0.0015460401,0.023146665,0.044174716,-0.010829533,-0.03680626,-0.08829507,0.033824638,0.025653938,-0.032275252,-0.032786068,-0.06434278,-0.048735123,-0.070166625,0.03721103,-0.034103718,-0.0726538,-0.010554828,-0.023437437,0.056027874,-0.03736753,0.060260788,0.06316673,-0.013396265,-0.027693743,-0.0590055,-0.045594566,-0.0027629042,0.025772309,-0.09535486,-0.007824844,-0.0844735,-0.03803987,0.0011707752,0.11880389,-0.06948282 +3.2.1.197,"The enzyme, characterized from multiple bacterial species, catalyses the hydrolysis of terminal, non-reducing D-mannose residues from beta-1,2-mannotriose and beta-1,2-mannobiose. The mechanism involves anomeric inversion, resulting in the release of alpha-D-mannopyranose. Activity with beta-1,2-mannotriose or higher oligosaccharides is higher than that with beta-1,2-mannobiose.",384,1.0,0.04834706,-0.0635849,0.012030112,-0.025418304,0.008542815,0.018569168,-0.015614844,0.027420621,0.023867205,0.13079762,-0.0026549925,-0.01766623,-0.07590352,0.026899632,-0.06206636,0.06285451,-0.0676274,0.029080644,0.012295773,-0.015804192,0.1013337,-0.03598373,-0.006019036,0.013717258,0.051148105,0.004411398,0.020560848,-0.051814202,-0.054953776,-0.117063925,-6.1013e-05,-0.055557705,0.059355937,-0.03778979,0.06527627,0.04558748,0.04601767,-0.038976207,0.07416787,-0.03629218,0.030860443,-0.034430888,0.028345486,-0.014478979,-0.05842928,0.00072259735,-0.07009336,0.10035605,0.06292216,0.011392885,-0.045942467,-0.052353848,-0.041266356,0.02176643,-0.018582096,0.073635995,0.032307453,-0.041189775,0.020563904,0.037913587,0.032852,0.041339222,0.047711156,0.018987872,0.025981614,-0.09522655,0.006378343,-0.09521326,-0.0510133,0.01179832,-0.05155182,-0.07710435,-0.0244104,-0.040809065,0.06855718,-0.044042077,-0.035292245,-0.07802172,0.047518976,-0.006052663,0.053957954,0.00080418604,0.07347157,0.03212902,-0.06431064,-0.007043757,-0.030261908,-0.032134805,0.16568919,0.043703582,-0.03298395,0.013340742,0.051441014,-0.044905946,-0.024040964,-0.07135997,0.015831117,0.053897914,0.06935276,0.014109506,-0.0012258933,0.02672862,-0.04887603,-0.09424212,-0.034203246,0.02600237,0.0073022586,0.009630289,0.048810676,0.00087788457,0.03471613,0.02892062,0.02494705,0.000694936,-0.12822971,0.074231535,0.06828642,-0.050650373,-0.07422205,-0.018217742,0.047634114,-0.051114436,0.05869969,0.0104252985,-0.07874846,0.061663743,-0.08175477,2.6916266e-35,0.052995507,-0.007155764,0.065662466,-0.018066797,0.056268662,-0.0009841166,-0.09421608,-0.047086734,-0.036809422,0.024713175,-0.1103636,-0.061712865,-0.013035065,0.0870971,-0.015067137,0.045936644,0.012136192,0.055323705,0.0034404604,0.009947384,-0.011869226,0.056239583,-0.03526935,0.009156552,0.11964107,0.05458157,-0.049556557,0.069815785,0.051071733,0.009305177,0.057689667,-0.03291276,-0.12673193,-0.0058667515,0.03699371,-0.016886935,-0.038153715,0.019674607,0.02647322,0.020923214,-0.008671149,0.021993246,-0.039644092,-0.08954046,0.016640292,-0.04399029,0.04696318,0.044580426,0.014506994,0.03903768,0.029495405,-0.043618795,0.022805542,0.028991159,0.0052750157,0.037638094,-0.024859672,-0.060558937,0.0881439,0.06575338,-0.02475687,0.029437637,-0.01858827,-0.060773563,-0.029939517,-0.019976437,0.006896672,0.0077553657,0.024543677,-0.019172303,-0.10551768,0.0070472327,0.04578857,-0.040526245,-0.0037187734,-0.05844878,-0.030162593,-0.0037750043,0.05972118,-0.044523325,0.035334084,0.0047329003,0.035815723,-0.01026989,-0.013202271,0.004894347,-0.08027062,-0.04538193,-0.048943788,0.034150504,-0.008116259,-0.018046143,-0.20588891,0.02575056,0.036858093,-3.0143292e-33,0.06023599,-0.07961705,-0.0025541654,-0.06873348,-0.071166724,0.0038709838,0.07963678,-0.02924231,0.02510863,-0.058948483,0.0008591026,0.015422593,-0.02530681,-0.025621226,0.0017811382,-0.027415533,0.02827675,0.088272974,-0.08038225,0.0055052787,-0.015004274,0.083471894,0.049534995,-0.042895064,0.028329974,-0.03370908,-0.0011784983,0.08204511,0.068547025,0.09547007,0.017635245,0.01373031,0.026697163,-0.06732808,0.0087851705,0.04456247,-0.09818914,0.04464808,0.021582952,0.02554649,-0.052562557,-9.790426e-05,0.010064247,-0.021089885,0.025523571,0.053333927,-0.06295979,0.025536068,-0.038401913,-0.046380498,0.006787305,-0.093117654,0.037107605,0.036930196,0.011515017,0.011489545,-0.018567536,0.044384472,-0.0071562147,-0.016100215,-0.017583456,-0.019520788,0.05157176,-0.016189244,0.036877368,0.059790406,-0.050344706,0.030883336,0.04276243,-0.012847123,0.0066823056,0.023336172,0.013775975,0.042495966,-0.014750808,0.00845092,-0.16721497,-0.077749096,0.001243817,-0.010336222,-0.07305843,0.040711455,0.0006780896,-0.04698674,-0.02367779,-0.067863934,0.06525302,0.113732435,-0.025448883,0.09703244,-0.040943436,0.029057337,-0.05182256,0.060527463,0.061135747,-4.0464478e-08,0.02652046,-0.047031555,0.07955773,-0.041044254,-0.0015658868,0.04998278,-0.005303597,0.027963422,0.07453645,-0.05818953,-0.039674025,0.13806534,0.029754667,0.032243486,0.02316801,0.0056222244,-0.007815905,0.013595165,-0.057763502,0.030408014,-0.12552199,0.033708062,-0.04537025,-0.029715484,-0.0069343965,-0.05722317,0.034576,0.0088265175,-0.077493295,0.008017979,0.02936363,0.0619526,-0.03380709,-0.073466316,-0.05050177,0.010850457,-0.070704505,-0.059555333,0.04529159,-0.03876679,0.031904984,-0.015151489,-0.01473591,-0.006796377,-0.015242242,0.056534465,-0.04737856,0.031103726,-0.03181685,0.044216808,0.026380057,0.0059791817,-0.12345094,-0.025504109,-0.07210192,-0.012933263,-0.018863084,-0.04093178,-0.0016486518,-0.041408364,0.048142362,-0.053689156,0.1354657,-0.07071478 +3.2.1.198,"The enzyme, characterized from the gut bacteria Bacteroides thetaiotaomicron and Bacteroides xylanisolvens, can also catalyse the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase.",384,1.0,0.0031955012,-0.038998414,-0.09966822,-0.07097945,0.056434486,0.018245256,-0.0847459,0.038475882,-0.008258086,0.053332705,0.07514534,-0.056325946,-0.056252085,0.035485566,0.0022939146,0.014789146,-0.057685245,0.035913352,0.00030302408,-0.05788077,0.05131655,0.024735713,0.020983005,0.036293924,0.007974914,0.016378392,0.020845385,-0.092417605,-0.038729604,-0.09550111,-0.011092285,-0.098542765,0.10035151,-0.07835901,0.057128266,0.04784951,-0.024555981,-0.11213148,0.034519635,-0.007110214,0.0038781865,-0.024369422,0.013510504,-0.11982673,-0.058109686,-0.031040998,0.02312738,0.049784474,0.11471979,0.024172464,-0.016383547,-0.049582697,-0.032688223,-0.025650742,0.06426061,0.0026583842,-0.10529794,-0.07808778,-0.0055727502,0.03531953,0.045290783,0.037654746,0.036077283,0.005967568,0.006545643,-0.046407238,0.04089635,-0.08637301,0.006306362,0.012235968,-0.05531468,-0.10762723,-0.02767058,0.0021420452,0.01208693,0.04794246,0.01708993,-0.058253452,0.042534105,-0.005431923,-0.009776526,-0.043082308,0.007529006,0.057394538,-0.050746217,0.00079950533,0.007174764,0.033515688,0.07428454,0.04059592,0.06758908,-0.06932161,0.05286793,-0.041987427,0.04679934,0.030612912,0.002542869,0.006834914,0.0637479,-0.029880349,-0.048952125,0.060410224,-0.031648923,-0.09170559,-0.019553743,0.036097042,0.032663427,0.06585855,0.028068257,0.0052442392,0.012910501,-0.05812926,0.008705362,-0.03922721,-0.0700785,0.06260948,0.10177045,-0.057852548,-0.07202396,-0.00033211047,0.07712688,-0.02717473,0.03148262,0.073971294,-0.010370213,0.064220585,-0.0516464,1.6907864e-33,0.0052662627,0.043655887,0.04496805,-0.0032515484,0.034800846,0.009114061,-0.0641088,0.029605702,-0.042782415,-0.023661247,-0.117616646,-0.009452441,0.031395048,0.06459032,-0.028911257,0.018731747,0.0038948618,-0.011707184,0.030706747,0.019752832,0.021382904,0.002909491,0.02976676,-0.03830067,0.075559296,0.061970446,0.00043333773,0.03865808,0.027812013,-0.008997467,0.04920825,-0.121710815,-0.076054275,0.07880549,-0.03594284,0.0032938244,-0.047939096,-0.05368501,0.046262443,0.10566008,0.0043288604,0.052364163,-0.0005433175,-0.025513567,0.007931526,-0.04816507,0.007146801,0.021436997,0.082537115,0.048655976,0.03758129,-0.023715185,0.032918554,-0.044219013,-0.009388091,-0.0032901242,-0.0113186,0.08754276,0.005778259,0.10612435,-0.03783325,0.111867934,-0.0008776029,-0.035727717,0.010667057,0.019174054,-0.04181048,0.022660097,-0.021190701,-0.018982964,-0.099748,-0.024734259,0.0935346,0.0050741793,0.034414746,-0.0564265,-0.041323017,-0.027637495,0.047685705,-0.00047937146,-0.0018287208,0.0095324945,0.035126,0.074520335,-0.06855792,0.015901256,-0.0977637,-0.039241776,-0.006861446,0.104868494,-0.0312393,-0.032479905,-0.07262434,0.09150942,-0.05697114,-3.4881656e-33,0.07312332,-0.1253295,0.030228844,-0.073074415,-0.07692732,0.0043800105,0.016149383,0.021518249,0.03709445,0.06061565,0.08833847,-0.022426615,0.070045896,-0.06229876,0.027282162,0.007055338,0.06686018,0.04519587,-0.049983803,-0.015205354,-0.009514897,0.056735963,0.03430999,-0.043859858,0.06441139,0.016221466,0.059006702,0.04685425,0.022232695,0.015768092,-0.03776164,-0.011226105,-0.033923823,-0.03605616,-0.004694786,0.023984944,-0.026096907,0.03902321,0.02516425,-0.042723056,-0.017338898,0.0693316,0.049007963,0.028209759,0.03691414,0.05852093,-0.021437323,0.015449654,-0.037548877,-0.037874654,-0.03549713,-0.023841463,0.009815361,0.052226853,0.023656558,0.03913733,0.0052295174,0.0012453196,0.049976736,-0.025640527,-0.054919735,-0.05705205,0.07728085,-0.05039353,0.10064367,0.04424317,-0.110302776,-0.0052156323,0.009747824,-0.0019535918,0.085882515,-0.06710339,-0.029938353,-0.0004996153,-0.044230986,0.028812757,-0.12389694,-0.12141312,0.0287929,-0.086432286,0.034779776,-0.013829318,0.009633412,-0.030881546,0.062143493,-0.01576609,0.032386877,0.18763267,-0.016061947,0.07348999,-0.051328365,-0.019903662,-0.026479969,0.061917666,0.05504159,-3.503896e-08,0.0010297991,-0.08538977,0.04472149,-0.035394892,0.008798604,0.10838497,-0.018387867,0.014954271,0.050015945,-0.037086245,-0.010418851,0.07262158,0.03238527,-0.022172352,-0.025417076,0.03374286,-0.045608226,0.018262211,-0.004530605,-0.0082335705,-0.113765955,-0.023636838,-0.095275246,-0.022850549,-0.023356762,-0.071669765,0.044965003,0.04914599,-0.06911997,-0.05217302,-0.051730398,0.0013018594,-0.0297242,0.01384897,-0.02577803,-0.043360375,-0.06375268,-0.025421157,0.004503739,-0.0015025395,0.01083224,-0.012748927,-0.04125506,0.006375548,0.021633698,0.0277157,-0.0051915394,0.032045502,-0.032240324,-0.017715538,0.07573491,-0.0740555,-0.0018124948,-0.040267322,-0.067087844,-0.060770497,-0.039929453,-0.07075256,0.025190527,0.005930744,0.0023408402,-0.022162344,0.1557386,-0.024517793 +3.2.1.199,"The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, hydrolyses terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol using a retaining mechanism. The enzyme belongs to the glycosyl hydrolase GH31 family.",384,0.99999994,-0.029085014,-0.08200014,-0.09441599,-0.036067586,-0.022272091,0.006078811,-0.02825041,0.01983192,0.014885328,-0.07960352,0.049151648,0.08330319,-0.08212713,0.079768494,-0.06163197,0.0005154272,-0.015455773,0.030072622,-0.031367145,-0.032244388,0.055247154,0.04364199,-0.05437997,0.08814554,0.03129388,0.027064897,0.013692151,-0.0049935724,0.0009777998,-0.009261937,-0.0069877747,-0.11793761,0.054711312,-0.078303196,0.06607973,0.06710322,-0.03451659,-0.021281002,0.049179286,0.009033882,0.015974265,-0.03506379,-0.02593287,-0.029295886,-0.019042717,0.014417518,0.0021852504,0.030200424,0.054531652,-0.00082941604,-0.022312546,-0.084623076,-0.07058771,0.031630516,0.049446985,0.0576118,0.0029462853,0.011844568,-0.03862379,0.055219598,0.021512683,0.033887867,0.0031723012,0.017956391,-0.11424757,-0.06930609,0.08635835,-0.05196013,0.037702415,-0.0001837189,-0.048062634,-0.052279633,0.044520557,-0.0064120125,-0.04616837,0.013466986,-0.03852239,0.004010493,0.09580877,-0.03001548,0.082689226,-0.056015883,0.0061586327,0.1442022,-0.05161439,-0.03193968,0.017671688,-0.04954974,0.09518556,-0.035617683,0.016004058,-0.057147745,0.0038183085,-0.081253424,-0.042488195,-0.03368149,0.008026427,0.018352643,-0.010114831,-0.01675621,-0.007532914,0.030258298,0.012381484,-0.09712271,-0.079384275,0.07281711,0.007300179,0.059211176,0.05721825,0.053833697,-0.030347276,0.06137208,0.060775943,-0.011551094,-0.025186596,0.011312627,0.044988904,-0.026205095,-0.08738947,-0.048441093,-0.010707458,-0.05151366,0.11249668,0.03199632,-0.059258886,0.06731254,-0.03933146,4.0867982e-33,0.11175095,0.07053815,0.022433255,-0.109542355,-0.031097941,-0.050232746,-0.07256193,0.06167552,-0.065358855,-0.005450018,0.044851836,-0.06259015,-0.03923703,0.026133094,-0.023128703,0.009203154,0.03444339,0.018969925,0.06928646,0.015802843,0.021256493,0.042866047,-0.00766513,-0.06037141,0.07979588,0.079816185,-0.0033693027,-0.007002723,0.00037592536,0.02436282,0.056684278,-0.07919698,-0.116986394,-0.036440697,0.09419098,-0.04344747,-0.057320394,0.012113783,0.044530906,0.041952625,-0.022596808,0.029102726,0.033100944,-0.053695776,0.06302065,-0.0013953913,-0.010951277,0.16471696,0.031040125,0.0729227,-0.019900968,-0.05864603,0.03965863,0.06668036,-0.036273085,0.0070033837,0.0051199114,0.04208296,-0.0038952855,0.009830109,0.037709665,0.12099423,-0.03576471,-0.031789035,0.018166542,-0.009968569,-0.078616954,0.044036206,0.0028881438,0.03383769,-0.024624862,-0.019229649,-0.003812687,0.031597864,-0.046869,-0.13254529,-0.0071232645,0.024209607,-0.020852515,0.003339495,-0.06750542,-0.010731411,0.006409271,-0.043285165,-0.08382101,0.045749217,-0.02214791,-0.031079913,-0.08251,-0.011895321,-0.055715673,-0.06948877,-0.0019701975,0.08909482,-0.024866715,-5.380311e-33,0.0974634,-0.11612471,0.056207784,-0.049137924,-0.046069212,-0.01593939,0.030706352,0.073943034,0.036554333,0.011929674,-0.018437598,0.06695863,0.009020381,-0.015815144,0.023934709,0.008479734,-0.032765806,0.048336454,-0.039458856,-0.060061563,0.06514456,0.04965993,-0.06828426,0.037916176,0.0744438,0.024415879,-0.015897684,0.0678576,-0.015340835,0.06567054,0.026085664,0.0031310415,-0.034968924,-0.100798674,-0.03343281,0.005667002,-0.072034106,0.011246331,0.0053219064,-0.002674839,0.02149951,0.052638885,0.020556416,0.04625544,0.034608874,0.07719793,-0.092237204,0.037465636,0.047485046,-0.05357737,-0.016566314,-0.04375402,-0.022553552,0.0857376,0.016054869,0.06489694,-0.012119369,0.054062363,-0.08674499,-0.036124013,-0.008526906,-0.06352757,-0.007305315,0.0064653056,0.0048744106,0.059252534,0.0017023298,-0.040824298,0.025104681,-0.0030992401,-0.047981642,-0.037342954,-0.024614379,0.07994822,-0.036624476,0.047609907,-0.09878932,-0.0462152,-0.00046128896,0.016678711,0.07171432,0.0094038015,-0.024781564,-0.047073,0.066478975,-0.087750584,-0.021858474,0.11075383,-0.034494676,0.03920653,-0.0056306054,0.0216533,-0.039748333,0.02465749,0.02597013,-3.7944485e-08,0.06712971,-0.086389534,0.051126372,-0.024884809,-0.0451078,0.030772084,-0.013586118,0.02279767,0.03236856,-0.06599085,-0.02921699,0.048631273,-0.033466753,0.007942747,-0.016304115,0.017211312,-0.041323353,-0.030490646,-0.055520613,-0.033711873,-0.013822665,-0.062186982,-0.07696418,0.03601605,-0.023012007,-0.096859954,0.06600571,0.04891712,-0.11599834,0.027858015,-0.008077529,0.019517213,-0.032013558,-0.00562292,0.05088646,0.071887635,-0.040784184,-0.013067316,-0.011323788,0.0031583377,0.020389505,-0.053480703,-0.045995787,0.0152730765,0.07229796,0.012690401,-0.0018881399,-0.0031722416,-0.01778553,0.04977889,0.031436615,-0.007076345,0.0017521443,-0.029513361,-0.08199983,0.004326401,0.029244363,-0.05536323,-0.059374463,-0.016969835,0.009829301,-0.02158698,0.20122276,-0.055841587 +3.5.4.43,"Contains Zn2+. This bacterial enzyme is involved in degradation of the herbicide atrazine. The enzyme has a broad substrate range, and requires a monohydroxylated s-triazine ring with a minimum of one primary or secondary amine substituent and either a chloride or amine leaving group. It catalyses both deamination and dechlorination reactions.",384,1.0,-0.048057295,0.009084942,-0.10897534,-0.005841495,0.14950654,0.040102612,0.036111876,0.05253307,0.037375335,-0.023831187,0.010494921,0.053143766,-0.005296588,0.04145536,-0.083254375,0.04557475,-0.03657904,0.0014928896,-0.0265622,-0.04891936,0.029299593,0.08734528,-0.0039358977,0.017671186,0.014666794,0.00069368473,-0.013340243,0.010194183,0.018623423,-0.034180656,0.07518234,0.07557476,0.032709427,-0.034711204,0.035332628,0.03222881,-0.03037816,-0.021442099,0.06840335,0.006558438,0.055431932,0.066761486,-0.030522011,-0.05066062,0.013983504,0.002684251,0.02058825,-2.4985071e-05,-0.018735955,-0.013702977,0.0073152897,-0.014384868,0.018445784,-0.006574114,-0.0018900872,-0.0067404876,-0.03901309,-0.005939378,-0.10873195,0.041262697,0.03804681,-5.272187e-05,-0.0571038,-0.0013789785,0.018310575,-0.0211969,0.043993123,-0.053306393,0.03336191,-0.049010206,-0.025214462,-0.10835152,-0.03757733,0.010648698,-0.025768077,-0.04672228,0.04943933,-0.057635047,-0.0043692845,-0.0798524,0.023686964,-0.047428224,0.055674464,0.02668512,0.081028715,-0.011267816,-0.07919227,0.024616169,0.09180833,0.042612668,0.05008653,0.08274034,0.038284,-0.057766948,-0.021907985,0.07890487,0.019122189,-0.03815159,0.007724998,0.055326845,0.03143487,0.043833215,-0.03694019,-0.08600728,-0.041391302,0.060361914,0.05775697,0.06706209,-0.025164349,0.0146924,-0.045059945,-0.01026742,0.03885534,-0.0029982168,-0.015187899,0.023091972,0.101723626,-0.025429532,-0.06457817,-0.051523384,0.0024946113,-0.022131205,-0.048744,0.054866467,-0.018343942,0.05526297,-0.12101167,3.041921e-33,0.0010296403,0.038844492,-0.112154976,-0.026805108,-0.06669927,0.037640043,0.0044171517,0.037771806,0.00040913172,-0.026156025,-0.062650405,-0.16535734,-0.026285294,-0.026122972,-0.029689196,-0.051958986,0.018418517,0.011122044,0.038443368,-0.0013538096,-0.009284491,0.043392558,-0.1349587,-0.019258529,0.04567789,0.05754405,-0.027300224,-0.026718251,-0.013619484,-0.028325351,0.050117295,-0.025736757,-0.12127171,0.04592222,0.09029034,-0.01301375,-0.11093297,0.062125828,0.03706009,0.06404383,-0.008519146,0.015783321,-0.04636363,0.053246737,0.051683314,-0.023382878,-0.057742108,0.12140597,0.033907223,-0.026159737,0.03920381,-0.018473271,0.015026003,0.027360212,-0.093934916,0.118750595,0.032377955,0.0016787722,0.056837197,-0.001980209,0.028787285,0.00060699426,-0.15963441,0.02311409,0.07193022,-0.03979086,-0.037887104,0.0011930532,0.03211778,0.075905144,-0.09426517,0.016951596,0.05134174,0.08615292,0.044735484,-0.072487645,-0.071682796,0.018436778,0.11498451,0.007650984,-0.043615103,-0.011557935,0.019951887,-0.003021514,-0.06385046,-0.005730643,-0.0011741471,-0.064960584,-0.022488585,0.0071276943,0.09368572,-0.10612039,-0.050965786,-0.00969572,0.046911936,-3.6318907e-33,0.017950026,-0.0066074706,0.0014324556,-0.020451872,-0.054258943,0.029016824,0.008129588,-0.050563045,0.00205161,-0.044766456,0.06266032,-0.0027933877,-6.0092832e-05,-0.023233814,0.031024192,0.028550068,0.0068226946,0.06998257,0.016222963,-0.053748902,0.0056905355,0.051777255,0.027360888,0.0037961996,-0.063172825,-0.0010748232,0.008426285,0.036820196,0.12834719,0.107082725,-0.012943746,-0.030608622,-0.03413954,-0.099564485,-0.022750137,0.034154944,-0.062960535,-0.0113908155,-0.12647489,-0.075282365,0.03649492,-0.044182934,0.0073166094,0.064971395,0.020354059,0.052220415,-0.08239446,-0.0032534131,-0.025217174,-0.075915575,0.07426417,0.016181922,-0.0073813414,0.013918724,0.054418374,-0.018477183,0.07543482,-0.06479201,-0.020775983,-0.03459655,-0.0037305246,0.011492439,-0.009336966,0.034232754,0.0498927,-0.01295233,0.00082517747,0.08757093,0.012316381,0.0030244344,0.012040485,0.06474829,0.022297323,-0.0067249797,-0.12305978,-0.02036082,-0.08726433,-0.023075256,0.062300973,-0.062617905,0.05606071,-0.008750031,-0.022153245,-0.042820226,-0.023853112,-0.056415074,-0.034786787,0.1144183,0.05183821,-0.024951002,-0.021831654,-0.02485245,-0.01608007,0.029470857,-0.0107989665,-3.9569215e-08,-0.031364646,-0.054693982,0.017063405,-0.09761692,0.013958187,0.03880718,0.028485514,0.04224311,0.021395719,-0.08415567,-0.028276958,0.06124994,-0.022351313,-0.004211031,0.04030337,0.04007969,-0.041405592,0.027382871,-0.008706862,-0.01973806,-0.050639886,0.024325917,-0.15977381,-0.04507872,0.013460665,-0.0013550104,-0.024639197,0.10270989,0.10243168,-0.031604722,0.043930497,-0.01197516,0.041119616,0.008717446,-0.059454598,0.015390649,-0.012385399,-0.12827308,0.040005248,-0.014486451,-0.028754035,0.052164722,-0.05260551,0.01229262,0.03242433,-0.056988023,0.06824288,0.008162126,-0.0006043472,0.014431452,0.029752921,-0.012596598,-0.008339904,-0.025103,-0.05026981,-0.037775047,0.029008338,-0.025973935,0.022199696,-0.029517068,-0.011907498,0.0055934265,0.14530899,0.022706825 +4.1.1.103,"The enzyme, characterized from several bacterial strains, is involved in the degradation of gamma-resorcylate. It contains a zinc ion and a water molecule at the active site. The reaction is reversible, but equilibrium greatly favors the decarboxylation reaction.",384,1.0000001,-0.09821656,-0.012194319,-0.03221074,0.0021223458,0.046385687,-0.013894571,-0.0060747196,0.04062923,-0.018455638,0.021482209,-0.0015014285,0.033683613,0.04728122,0.07250535,-0.095710136,0.0025392,-0.033225533,0.03986018,-0.0384228,-0.024143452,0.01713442,0.027712679,-0.042817306,-0.022308366,0.06836109,-0.0061969315,0.04437453,-0.037218932,-0.047928113,-0.04724483,-0.00023387343,0.0077483268,0.011047805,-0.0033557941,0.050328873,0.14369203,-0.030507265,-0.080888465,0.03399751,0.007401482,-0.017299654,0.082011685,-0.009954428,-0.026579767,0.04350988,0.01898711,-0.005366061,-0.017546203,-0.018623361,-0.02910717,-0.011001202,0.007843929,-0.032986395,0.07516719,-0.012122217,0.059623215,-0.06434886,-0.058072273,-0.061925232,0.02316832,0.03010436,0.00022651535,-0.03620268,-0.021021817,0.05649054,-0.030393153,-0.0059876847,-0.05567636,0.02224197,-0.008407669,-0.08593954,-0.040980756,-0.085173465,-0.044950165,-0.04228969,-0.048655286,0.01770269,-0.030119846,0.059502948,0.0042573656,0.057944875,-0.032275394,0.0867395,0.0802396,0.05735835,-0.006145002,0.020133108,0.0069488725,0.08895577,0.0744461,0.024121698,0.044219688,0.047170814,-0.03106999,-0.06615614,0.04534317,-0.009983385,0.013076476,0.1001205,0.029325662,0.0029715085,0.019556407,0.047459897,-0.08380893,-0.06301286,-0.0017864681,0.018130753,0.108454645,-0.014549555,0.09451604,0.006359781,-0.029232724,0.036787365,0.026951682,0.031311627,0.08737729,0.06379063,-0.018254705,-0.11144937,-0.05472308,0.008894927,-0.03290464,-0.01445946,-0.007057785,0.008843185,0.09720164,-0.0860947,-8.853988e-34,-0.0021385166,0.0004464522,-0.027359122,-0.019846138,0.029493704,0.030404175,-0.03961699,0.055715933,-0.036079917,-0.04246482,-0.03328905,-0.0038991396,-0.004443961,0.011309208,-0.06638469,-0.043489736,-0.017123448,0.09867151,-0.01129636,-0.00047908997,0.031803813,0.07828234,-0.04708552,-0.042559702,0.021266287,0.015650857,-0.054746352,0.043496393,-0.027946355,-0.038507327,0.081924915,-0.074834816,-0.11579969,0.014851421,0.09484575,0.034218576,-0.023245092,0.020979036,-0.027429607,0.055490095,0.01862725,0.043068748,-0.082200184,0.001833782,0.05988328,-0.06269169,0.022223933,0.07008033,-0.015026752,-0.055965327,0.021542406,0.016025629,0.0032847403,-0.06800411,-0.044730563,0.06841994,0.033614576,0.018488823,0.010430471,0.0026549147,-0.02334874,0.04238395,-0.07175807,0.046685956,0.0661368,0.023069208,-0.07301537,-0.05761425,-0.03809687,0.07848754,-0.08732623,0.0011101718,0.058239695,0.005504279,0.030503413,-0.06445078,-0.08229147,0.03445575,0.04266025,-0.04918525,-0.07771637,-0.054952987,-0.039985053,0.020153645,-0.055504184,-0.0601048,0.010187219,-0.09159651,0.03491428,0.045476835,0.08884302,-0.05697396,-0.055983175,-0.0048712785,0.03989193,-3.3742545e-34,0.044337563,-0.07556918,-0.020712767,0.02875407,-0.04358392,0.053187776,-0.00015953956,-0.0010467481,0.029601727,-0.082439065,0.057300463,0.017031552,0.00830701,0.020763628,0.00494786,0.04128615,0.013372946,0.12242794,-0.019683396,-0.06833016,0.014313891,0.11845706,0.030011104,-0.06694408,-0.013602799,0.007922077,-0.017782914,0.05009107,0.13983561,0.07553415,-0.04842837,0.0092607085,0.021645078,-0.07326456,-0.054762673,0.059305493,-0.053259224,-0.0026283835,0.04971836,0.021727983,0.03594667,0.0104648,-0.013762851,0.07090406,0.084267125,0.10469492,-0.061897803,0.012820437,0.048079386,-0.059213035,0.015112453,-0.0366809,-0.023493255,0.03678427,-0.004473002,0.06409528,-0.013910484,-0.048087317,-0.03352272,0.006466882,-0.045262266,-0.099371724,0.04562113,-0.0035715215,0.057106104,0.02098162,0.026760576,0.081387244,0.047495686,-0.10863848,0.1307463,0.0155661795,0.040903322,0.021916566,0.022041842,-0.016770313,-0.0991982,0.017517483,-0.040483516,-0.01958552,-0.014680439,0.06418958,-0.052212175,-0.08103639,0.022464504,-0.08378913,-0.009382552,0.08180655,-0.013828594,0.011768464,-0.046812873,-0.06986598,-0.025258211,0.05769843,0.04833429,-3.342058e-08,-0.019713173,-0.01929408,-0.014092953,-0.043187965,0.038603403,0.06664195,0.066828206,0.057383724,0.072193325,-0.030584263,-0.007319385,0.11010674,-0.022573132,0.023379063,0.020155726,0.06926546,-0.05755613,-0.029513339,-0.05347913,0.032576926,-0.029848907,-0.045036826,-0.045119062,0.03640016,-0.0414242,-0.03793481,0.068307005,0.05813777,-0.09676943,-0.07428743,-0.029390538,0.10238299,0.08462624,-0.021682259,-0.1055289,-0.0535232,-0.009654424,-0.062486257,0.016988743,0.04807441,-0.037469648,0.017616985,-0.114235476,0.016988339,0.013006505,-0.0013936415,-0.0065577566,0.00094710675,-0.043420233,0.029906845,0.05273207,-0.022833848,-0.049182624,-0.075868234,-0.016972447,0.022840815,0.006386592,-0.014554413,-0.013137567,-0.017264372,0.011550932,0.03466526,0.1590774,-0.113005705 +4.1.99.22,"The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). In bacteria and plants the reaction is catalysed by MoaA and Cnx2, respectively. In mammals it is catalysed by the MOCS1A domain of the bifunctional MOCS1 protein, which also catalyses EC 4.6.1.17, cyclic pyranopterin monophosphate synthase. The enzyme belongs to the superfamily of radical S-adenosyl-L-methionine (radical SAM) enzymes, and contains two oxygen-sensitive FeS clusters.",384,1.0,-0.052717857,-0.088661045,-0.13589397,0.026936363,0.076929234,-0.00476552,-0.092169054,-0.04626278,0.039987404,-0.023457116,0.024958601,0.021726305,9.156609e-05,0.02338994,-0.06153061,0.049951848,-0.05485003,-0.013268777,0.06678973,0.040841125,0.07475531,0.008585377,0.016252274,-0.04147112,0.017128177,0.039929003,-0.01548675,-0.012775009,0.01907221,-0.041317847,0.025121408,0.028842349,0.070186764,-0.06464858,0.039345562,0.075605415,0.036760982,-0.06026056,0.07482277,0.015301875,-0.01812443,0.052344196,0.051273588,-0.07478626,-0.02076124,-0.042188875,0.058875542,-0.022805953,0.0071646627,-0.0009377171,0.005955418,-0.07161987,-0.10852713,0.0033042566,0.060550027,0.03844471,-0.07913533,0.021017004,0.081742905,0.0022381665,0.022589877,0.027576832,0.05315668,0.05620232,0.053290013,-0.09513809,-0.02679069,-0.0601111,0.026490534,-0.08274879,-0.09380596,-0.028720018,0.02113441,-0.009530558,-0.065584876,0.05818738,-0.0025539899,-0.03477094,0.04954706,0.018166937,0.020484641,0.024987034,-0.021659214,0.03129282,0.056013227,0.0113498885,-0.021008952,0.012475191,0.04524171,-0.043352358,0.023637095,-0.028952215,-0.0058965557,-0.00035752065,-0.03982461,0.004131505,0.09094094,0.06228224,-0.058375806,-0.020329481,-0.03252556,0.055554047,-0.018644081,-0.045631967,-0.08411923,-0.018002536,-0.03412016,0.12750767,0.023835061,0.0512379,-0.03633547,0.105136834,0.038081717,-0.03763839,-0.011808728,0.016779786,0.03043593,-0.02683877,-0.04661323,0.0016570421,0.032783613,-0.039080944,-0.026472177,0.05150015,-0.035043973,0.027085066,-0.08490463,2.3054493e-33,0.119327806,0.04195643,0.05662745,-0.014563619,0.044854306,-0.03613831,-0.029741624,-0.043849986,-0.009500787,-0.041830584,-0.014418477,-0.057764154,0.06393018,-0.06308867,-0.043562125,-0.02196624,-0.039278224,-0.079873934,0.056029104,0.016071001,-0.037510164,0.020686518,-0.012940293,0.031765398,0.04144129,0.009075655,-0.04008766,0.006288243,0.09366481,0.033545345,0.0023596233,-0.051141225,-0.1178287,-0.021586355,0.027315604,-0.023195239,-0.0649777,-0.075489014,0.0088533405,-0.02429535,-0.06744216,-0.014604965,-0.03477422,-0.045361377,0.03391405,0.0005032675,-0.031006927,0.12481669,0.05743677,0.009192776,0.0051865927,-0.029282067,0.0110742105,0.006388375,-0.09429057,-0.010112839,-0.025036307,-0.09753657,-0.027136998,0.13452187,-0.03385832,-0.01848684,-0.010388172,0.04589008,-0.037404526,-0.04731828,-0.07748095,-0.033481434,0.061597187,0.106552705,-0.018742194,0.025435708,0.018122561,0.011652859,-0.008092178,-0.04574454,0.07393668,-0.077873565,0.027869595,0.002343249,0.050416164,0.031247884,0.040081546,-0.08027491,0.011315802,-0.02622325,-0.12480971,-0.042932067,-0.03223513,0.06747751,0.0040594395,-0.027178375,-0.031982902,0.0041953526,-0.043719318,-2.9585532e-33,0.093469545,-0.07241399,0.07406957,-0.10661156,-0.08501099,0.032382164,-0.007090396,-0.06964304,0.020723572,-0.042620268,-0.010752224,0.007001008,0.03185255,-0.074140295,0.027120491,-0.023948887,0.030726206,0.07351053,0.044210885,0.0010868919,0.06459024,0.04081793,-0.021073539,-0.026533969,0.023482675,0.04423564,-0.048137702,0.047723178,0.083527975,0.043412138,0.012195006,-0.045371,-0.100361764,-0.04490252,-0.034843907,0.013742287,-0.059432387,0.028403662,0.049845405,0.002287339,0.03609772,0.03977226,-0.007435756,0.06801188,0.06552145,0.013577864,-0.047919136,0.054581698,0.031665295,-0.020840574,0.0031408137,-0.032359906,-0.02180266,0.021624157,0.051856544,0.035882115,0.031910367,0.029770084,0.0150043825,-0.04237018,-0.0038656967,-0.010342799,-0.018814476,0.011458332,0.013119227,0.08544821,0.039848514,0.07914111,0.05368208,0.015631901,0.015538786,0.033975523,-0.06656738,0.003982661,0.014730285,-0.009716041,-0.09082646,0.0042951284,-0.013400386,-0.007352081,0.022756673,0.08551716,0.011241828,-0.09365906,0.034493815,-0.0034890568,0.055723388,0.12455829,0.065411896,0.005436827,-0.0894435,-0.035672575,-0.011920296,0.0048260856,0.036167502,-3.6885314e-08,-0.07999148,-0.084603794,0.02080571,-0.05691661,0.0064921295,0.1329799,0.012798892,-0.030305224,0.04318422,-0.06304381,0.06196291,0.096100606,0.043500613,-0.030666461,0.010612681,0.06546128,-0.049986906,-0.008279139,-0.0042631347,0.02304952,-0.015979737,0.0008838053,-0.09483292,0.14988711,-0.038218025,-0.071184285,-0.024230763,0.12178215,-0.059137102,0.04482205,0.0058298213,-0.024128705,0.018166108,-0.055210415,-0.10103859,-0.060152195,0.01757627,-0.01629347,-0.007882835,-0.007661473,0.01717012,-0.0147353355,0.029864328,0.02239393,-0.035289764,0.040113404,-0.03537431,0.0529763,0.0026114208,0.06146353,0.05707148,-0.057641108,-0.0375869,-0.0507928,-0.112350896,-0.038930602,-0.019475678,-0.07929732,-0.0039993213,-0.050899263,-0.027671507,0.0017007929,0.1617245,-0.0018331674 +4.2.1.168,"This enzyme, involved in beta-L-colitose biosynthesis, is a unique vitamin-B6-dependent enzyme. In the first step of catalysis, the bound pyridoxal phosphate (PLP) cafactor is transaminated to the pyridoxamine 5'-phosphate (PMP) form of vitamin B6, using L-glutamate as the amino group donor. The PMP cofactor then forms a Schiff base with the sugar substrate and the resulting adduct undergoes a 1,4-dehydration to eliminate the 3-OH group. Hydrolysis of the product from the enzyme restores the PLP cofactor and results in the release of an unstable enamine intermediate. This intermediate tautomerizes to form an imine form, which hydrolyses spontaneously, releasing ammonia and forming the final product.",384,1.0,-0.039485317,-0.092618465,-0.03364918,-0.05747331,0.076387025,0.101669125,0.0075397044,0.054835685,0.0144910095,0.034635104,0.0255949,0.0059750336,-0.052320685,0.041429967,-0.04971726,0.09243435,-0.06601845,-0.011190152,-0.013735135,-0.016418837,0.09317375,-0.023967098,0.0018709161,0.025663203,0.061237123,0.11314442,0.10718377,0.0015117646,0.042041756,-0.02103664,-0.06571546,-0.0031508165,0.035316743,-0.0788596,0.033902973,0.08087013,-0.008406776,-0.010823457,-0.00872194,-0.03178894,-0.020991903,-0.006497435,-0.029373694,-0.0263225,0.060333215,-0.055735778,0.060420226,0.07965733,0.014200708,-0.04713295,-0.03859887,0.015685767,-0.0152700255,-0.017580135,0.045704316,0.007969426,-0.061335307,-0.049276624,0.0019960934,0.010853313,-0.042159732,-0.055855427,0.04066944,-0.0013304177,0.10294806,-0.033490606,-0.006320803,-0.041737277,0.0009941384,-0.07793667,-0.11427101,-0.07250733,0.016546786,-0.053612605,-0.00716831,0.029284831,0.0152624985,0.014348157,0.0040378775,0.07069515,0.024258029,0.006799584,0.02019669,0.10414933,0.05862018,-0.023111142,0.063789375,0.017533025,0.031781115,0.0102337925,-0.034533802,-0.03899157,-0.021147175,-0.0020100514,-0.08985815,0.027062537,-0.051204324,-0.012193093,0.039225515,-0.03393491,-0.037920665,0.04722576,-0.020754045,-0.055824943,-0.05601828,-0.042770553,0.022640007,0.16676793,0.065766715,0.012610587,0.005937828,0.05777239,-0.03695916,0.0990675,0.020304129,0.07346105,-0.008602874,-0.040704332,-0.03164269,-0.026424685,0.033069644,0.010861417,0.045281634,0.064342156,-0.1018239,-0.012021287,-0.08428066,3.1129684e-33,0.048180643,0.06532338,0.020703254,-0.0030131335,0.016914466,-0.0071999626,-0.085658185,0.04269223,-0.0643585,0.019873604,-0.041620873,-0.055999972,0.06677863,0.005862497,-0.025060209,-0.11023644,-0.07872505,0.0046488014,0.093014315,0.03181271,0.021519193,0.063055806,0.0064592636,0.03067645,-0.0059509715,0.08140776,0.020623729,0.0680816,0.03296178,-0.025355551,0.04657248,-0.045792904,-0.10111698,-0.019079136,-0.0017475632,-0.036618702,-0.054015663,-0.011288591,-0.008352649,0.09704805,-0.007735986,0.019285152,-0.0779064,0.035855025,0.058303963,-0.07501559,-0.052877884,0.08449508,0.0027345265,0.03168942,-0.0005937251,0.009074078,0.09240733,0.0049417317,-0.08907705,-0.025890164,-0.04220904,-0.076263115,-0.009737898,0.037165828,0.021278486,0.03105948,-0.048086263,0.03122788,-0.06652186,-0.041171197,-0.031770274,-0.068836026,0.0690118,0.027192054,-0.022135692,0.05120608,0.0511921,0.014511966,0.006354154,-0.080579445,-0.047585838,0.08680024,0.030485118,0.038897082,0.019733563,-0.04083116,-0.012876845,0.0021427688,-0.053927325,-0.021148147,-0.045765214,-0.08466446,0.0394221,-0.008214538,0.011491426,-0.0849036,0.026204009,0.0379237,0.0052098455,-2.8270736e-33,0.10988364,-0.1278807,0.08180565,-0.041261423,-0.042503245,-0.0002485188,0.085665606,-0.086845204,0.03833088,-0.04169779,0.00965472,0.015515164,0.057201844,0.007850308,0.009390289,0.03165104,-0.00315066,0.068319075,-0.011142534,-0.01617225,0.064990886,0.04666524,0.009990064,-0.00697861,0.046603538,0.09576487,0.07030465,0.005178564,0.05419026,0.024242368,0.0052181496,-0.0070373397,-0.06019057,-0.048218098,-0.017747764,0.042606268,-0.0942104,0.002495833,-0.00902287,0.053613566,-0.001014914,0.094680436,-0.019052606,0.0068250755,0.008335589,0.054408308,-0.030893622,0.02618912,0.006526944,-0.02605114,0.05599226,-0.013747349,-0.04715961,-0.0046380926,0.03173871,-0.0044573583,-0.02047512,-0.03877433,0.0054767816,-0.013213422,-0.026070803,-0.08266919,0.0105127385,0.01541457,0.010696821,0.03669979,0.050051853,0.04526977,0.025360407,-0.02607215,0.02578029,-0.040463593,0.07171499,0.06649099,-0.004605326,0.015014713,-0.053713214,-0.07252537,0.0032201018,-0.08298636,-0.02441289,-0.043795414,-0.046644222,-0.06674772,0.0065896553,-0.12185372,0.08622253,0.08399279,0.022975782,0.032587606,-0.023130331,-0.0017879165,0.0015601572,0.08690515,0.11200907,-4.827243e-08,0.01810354,-0.11056371,-0.02555373,0.004551589,0.030905265,0.042301215,-0.019562813,-0.06501862,0.11313482,-0.09614525,-0.016312774,0.078267634,0.0064843562,0.013089517,0.0059360517,0.006569133,-0.01142956,0.0033692443,-0.006078049,-0.057191,-0.13926928,-0.030332291,-0.06654958,0.008406367,0.013928251,-0.07971385,-0.076422304,0.047255106,0.0044345357,-0.025428224,0.027012717,0.06730017,0.03099157,-0.029029652,-0.031276643,0.056288388,-0.008349946,-0.008359648,-0.006324757,0.028268194,-0.016045727,-0.08065478,-0.0580087,-0.006948381,-0.012710091,0.03478048,-0.07195953,-0.009062896,-0.07350701,0.05275448,0.0774663,0.00077145407,0.0013727738,-0.054536663,-0.07279831,0.053747233,0.0039895303,-0.09446608,0.03939869,-0.0774688,-0.0012702028,0.026455697,0.12921275,-0.10058501 +4.2.3.156,"This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 1.17.8.1, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.",384,1.0,-0.05069414,-0.025605626,-0.021095565,-0.013193275,0.062105432,0.00836295,-0.14002031,0.036648527,0.006439915,0.0295144,-0.007967281,-0.07665314,-0.027184658,0.032403104,-0.03736062,0.00019174775,-0.056627106,0.021764306,0.07361723,-0.00441969,0.14104506,0.04395951,-0.01974565,-0.003718472,0.05063636,-0.022937294,0.09959026,-0.05442003,-0.017282324,-0.053056646,0.026947195,-0.07803962,0.07154277,-0.062951535,-0.001277173,0.09187863,0.013628773,-0.10050561,0.07459853,0.05519448,0.021253614,-0.018138237,0.0324954,-0.054057937,-0.024827195,0.04548745,0.03276025,0.056682564,0.008976837,-0.086684585,-0.067140914,-0.066987686,-0.046594962,-0.0028079818,0.0026799168,0.008427365,-0.024284167,0.011837305,0.008543341,0.0102885,0.07243775,-0.031096058,0.027712135,-0.06991221,-0.015646184,-0.073867425,0.05533183,-0.031417727,0.0431576,0.009131807,-0.13105056,-0.011882423,0.01067753,0.037352845,0.0076559572,0.009354498,-0.0073660035,-0.035343185,0.03196906,-0.037370373,0.024561116,-0.059608795,-0.038468026,-0.010407956,0.018597865,-0.020165816,0.038385417,0.044829182,0.063025355,0.007000205,0.027438588,-0.017376762,0.03863179,-0.008580843,-0.089498244,0.04836433,0.0055803135,0.13284245,0.038202886,-0.07945797,0.089350596,-0.00585396,0.0009777255,-0.12195312,-0.028393464,-0.02915373,0.057134226,0.058509722,-0.0011286372,0.013113764,-0.01782116,0.01933783,0.040508382,-0.0029607906,-0.058358733,0.07989574,-0.019423356,-0.08229536,-0.07419955,0.014459497,-0.022002826,-0.011446189,0.020000735,0.096620105,-0.0024880536,0.029787572,-0.1539666,3.9912908e-33,0.04451795,0.07140327,0.020611428,-0.033897396,-0.0369084,0.03232225,-0.10261655,0.036860142,-0.05134545,-0.03929109,-0.038725246,-0.012825886,0.03933923,-0.004790354,-0.023473937,-0.077626415,0.011296242,0.028159373,0.08617333,-0.0048514293,-0.020806588,-0.0425526,-0.08531549,0.024656033,0.06285753,0.033417363,0.02617913,-0.05692579,0.056323975,-0.029761555,-0.008043119,-0.11765111,-0.07186262,0.020396503,0.06574494,-0.083414264,-0.013914674,-0.076354034,-0.008154531,-0.07515108,-0.017887602,0.012207429,-0.014383485,-0.024164738,0.058748186,-0.03960934,-0.06002962,0.061150897,0.07018799,0.004667721,-0.028700428,-0.0250084,0.08995994,0.012327283,-0.054866977,-0.038150374,-0.05596137,-0.019955056,0.07296703,0.036721002,-0.0048462944,0.061460856,-0.05731417,0.010731748,-0.0151280435,0.049678966,-0.011249906,-0.049543343,0.01878091,0.08402508,-0.058976755,-0.051905066,0.046588834,0.015976895,0.022303544,-0.027794236,-0.055303965,0.018484227,0.04406683,0.0042761187,-0.020098291,-0.009648121,-0.034675088,-0.051244006,0.008268027,0.0012717895,-0.041697852,-0.013318524,0.027709255,0.097547516,0.05401146,-0.15861323,-0.06340782,0.053835206,-0.039741646,-3.202903e-33,0.10699963,-0.035070825,-0.038376953,-0.064632535,0.016257405,0.05132331,0.060438808,-0.023865305,-0.012534194,-0.06383339,0.08976152,-0.049550656,0.07629524,-0.06918357,0.008884106,0.013593051,0.069743246,0.009425119,0.021034947,-0.015527817,0.012919533,0.0397984,0.04091272,0.04776612,-0.002973606,0.0028493674,0.056081697,0.123086326,-0.00688598,0.079244316,0.0032923974,-0.0009073133,-0.06443986,-0.037577327,-0.058940068,0.011404872,-0.049847476,0.0359621,0.05331356,0.0172613,0.028427016,0.011019689,-0.05716919,0.0739224,0.03143393,0.08814926,-0.009904472,0.018701684,0.0005663499,-0.08753134,0.02980776,0.028044853,0.051047403,-0.00893911,0.009772135,-0.028504483,-0.027444864,0.05778627,0.01595788,-0.022248685,-0.04814084,-0.07380474,0.037984706,-0.05532833,0.03209945,0.07118806,-0.024944682,0.10402045,0.0070763566,0.03732168,0.063923575,0.018534685,0.0048691956,0.020571345,-0.06040562,0.034158528,-0.0104398765,-0.05773913,0.0034384558,-0.015627673,0.08046132,-0.016286694,0.033416368,-0.045580637,0.012447986,-0.045619793,0.07265794,0.07214972,-0.028697174,0.05886843,-0.053326484,-0.038056474,-0.044242185,0.06397929,0.11774756,-4.0238135e-08,-0.010611749,-0.05435262,0.06511156,-0.0115746055,0.028763616,0.027591094,0.008454952,0.03534351,0.019305268,-0.00434215,-0.02354284,0.009768955,0.05832602,0.03341137,0.079485394,0.027403483,-0.057774875,0.071160235,0.013165224,0.048689026,0.036187705,-0.043181937,-0.155047,0.061145842,0.0053228023,-0.02602535,0.06899501,-0.025468493,-0.016290922,-0.07567407,0.02986061,0.018912762,0.016164022,0.04065801,-0.08673758,-0.022190176,-0.08670581,0.03605713,-0.045351833,0.03216423,0.0018360476,0.019114254,-0.09995596,0.041834876,-0.018826462,0.025199587,0.004071342,-0.0034719708,0.037656013,-0.02998344,0.060936373,0.004062672,0.035043478,-0.05283483,-0.042175487,-0.043763764,-0.06529082,-0.027307522,-0.048900414,0.02040562,0.040412042,0.017207531,0.17647527,-0.019974755 +4.4.1.34,"The enzyme, characterized from the bacterium Rhodococcus sp. AD45, is involved in isoprene degradation. The enzyme can catalyse the glutathione-dependent ring opening of various epoxides, but the highest activity is with (3R)-3,4-epoxy-3-methylbut-1-ene, which is derived from isoprene by EC 1.14.13.69, alkene monooxygenase.",384,0.9999999,-0.047409847,-0.017555403,-0.082322,0.012835379,0.07333029,0.04223181,-0.098914765,0.05814447,-0.012358791,-0.055683874,0.0191716,-0.0024454347,-0.045945134,-0.019254088,0.0064853444,0.011942618,-0.053941023,0.006610763,-0.010985968,-0.053376485,0.031381875,-0.022675583,-0.042001516,-0.012957417,0.056176763,0.011394119,0.039313246,-0.04018329,-0.041981783,-0.05780515,0.02069924,-0.14944462,0.08818099,-0.030561846,0.0086101,0.08170046,-0.04365017,-0.015167471,0.058121074,0.017802399,-0.03849953,0.00728022,-0.0098875165,-0.047761455,-0.02726838,-0.03276564,0.0003974485,0.018391289,-0.0019182735,-0.03509653,0.049312208,-0.038188368,-0.025647033,0.05017278,0.09636898,0.005492769,-0.01664647,-0.04793973,-0.06779808,0.0022281117,0.07831823,-0.023791187,-0.048115134,-0.024878398,-0.06878057,-0.05605446,0.07083527,-0.052110948,-0.015718527,-0.011618117,-0.04518037,-0.037227325,-0.058137488,0.0365084,-0.00851369,0.079371534,-0.06448532,-0.0691538,0.032962453,0.0009358399,0.056232173,0.014216418,-0.0038433587,0.07690813,0.07080007,0.020583218,0.032956045,-0.040169064,0.025757268,0.028600972,-0.0050575486,0.021848222,-0.022136766,-0.0016136311,-0.060771704,0.054314274,-0.0012410341,0.031116208,-0.029633766,-0.012621014,-0.033710334,0.05615705,-0.07522209,-0.1107423,-0.029902875,-0.009045184,0.00642966,0.13030452,0.048594948,0.015525504,-0.001798677,-0.022786811,-0.0075893276,-0.018553173,-0.017738117,0.085876346,0.039367806,-0.06431205,-0.101316296,0.01957153,-0.024211438,0.015578696,0.016117353,0.04710154,-0.05795259,-0.017952839,-0.0153085785,1.8404875e-33,0.028033009,-0.018624226,-0.02504343,-0.029184323,-0.011420939,0.047034547,-0.083449066,0.023823325,0.013413985,-0.0704901,-0.052326694,-0.025658872,0.016192518,0.016158888,-0.009902779,0.005683423,-0.02652824,0.04495953,0.04015454,-0.03565858,-0.0045927884,-0.035128325,-0.086397775,0.021623015,0.0128438175,0.05634702,0.01898113,-0.030566528,-0.0024277687,-0.0028488452,0.029769074,-0.053990703,-0.11227482,-0.00822155,0.03568661,-0.03209964,-0.006644172,0.013995935,-0.027319353,0.027419241,0.06737128,0.045349207,-0.0025210541,-0.06910976,0.09157878,-0.06601859,-0.02320869,0.16409059,0.05559298,0.100923434,0.046094183,-0.037450172,0.03300144,0.029352555,-0.09645699,0.034019113,0.0141708935,-0.015716512,0.06335355,0.04948963,-0.011315939,0.13034683,0.029249614,0.011723479,0.01394123,0.059528403,-0.057416596,-0.05503931,-0.040455658,0.13580088,-0.024825124,-0.049491566,0.03125624,0.0142548755,-0.035529744,-0.033083387,-0.058483828,0.04521638,0.11249113,-0.006915771,-0.061190583,0.0454829,0.047718413,-0.043769583,-0.045601916,0.0011731482,-0.020289464,-0.01989143,0.02655037,0.11306397,0.13617624,-0.049479987,-0.07665838,0.047983665,-0.05379738,-2.2528726e-33,0.10368975,-0.12710178,0.051902477,-0.114504576,-0.0068488144,0.07609785,-0.04855664,0.034473836,-0.014498045,-0.046079043,0.09501764,-0.010112619,0.038524956,0.06694774,0.09073624,-0.07756767,-0.00029274428,0.012432584,0.016555995,0.05138042,0.047739975,0.01334165,0.019146806,0.07910019,0.032565497,0.0067578345,0.013608889,0.06697435,0.060778964,0.012010478,-0.045613486,0.022594577,-0.06400501,0.046654787,-0.021780275,0.093382694,-0.024163112,0.032034688,0.016362634,-0.04004112,0.008073519,0.007400637,-0.07632528,0.044544403,0.034471203,0.066002764,-0.081107,0.024133759,-0.006880787,-0.09049181,0.045786314,0.0026096737,-0.0005612772,0.008469013,-0.01209392,0.039221577,-0.07199617,-0.02827342,-0.027071973,-0.021796292,-0.012615248,-0.036613464,0.036611468,0.03204977,0.021309199,0.028035987,0.023009825,0.05809059,-0.061005864,-0.037054736,0.093593985,-0.065997005,0.018257596,-0.0143030705,-0.06481063,-0.084001556,-0.029995061,-0.017091315,-0.035920467,0.011805124,0.011818975,0.010953058,-0.034462858,-0.03811977,-0.03174446,-0.045504034,-0.028224325,0.10970387,0.025617005,0.07972376,-0.065006986,0.065076135,-0.05271049,0.024157867,0.097957514,-4.0735742e-08,-0.004183739,-0.011522416,0.13425788,-0.0045642103,-0.013169163,-0.011444303,0.020866849,0.046838555,0.033520922,-0.008752157,0.0559121,0.09858535,-0.02979557,-0.018936474,0.0065433476,0.018726239,-0.044195667,0.034487672,0.020380754,-0.00038576216,-0.10834287,-0.018376421,-0.012901212,-0.059261154,0.0004225471,-0.039579667,0.09340784,0.037245046,-0.008600064,-0.015599406,0.03305826,-0.0029845785,0.014981338,0.05667484,-0.08486901,0.023426494,0.03441829,0.012192046,-0.101797014,0.018320635,-0.03993534,-0.01562714,-0.09543993,-0.007744614,-0.0048843343,0.0384575,0.028047122,0.028678726,-0.026299188,-0.030832425,0.0039668684,-0.047038663,-0.009488762,-0.057324946,-0.123412065,0.01651438,-0.059939332,-0.03431689,-0.049926545,0.039807025,0.002018524,0.014393882,0.18490082,0.0713383 +4.6.1.17,"The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). In bacteria and plants the reaction is catalysed by MoaC and Cnx3, respectively. In mammals the reaction is catalysed by the MOCS1B domain of the bifuctional MOCS1 protein, which also catalyses EC 4.1.99.22, GTP 3',8-cyclase.",384,1.0,-0.07284069,-0.06546061,-0.09850482,-0.011705743,0.051368657,-0.02114097,-0.07385054,-0.057216637,0.029474294,-0.034162916,0.042456843,-0.02711721,0.019107128,0.03501722,-0.05547625,0.012737368,-0.05739391,0.017523756,0.0383144,0.026208349,0.071023464,0.013024741,0.009538215,-0.036943465,-0.009769443,0.030906394,-0.027548665,-0.03584908,0.04682379,-0.06171426,0.014352984,0.0534725,0.043434832,-0.09462905,0.08793047,0.023875354,0.05004569,-0.0688703,0.07870958,0.038256723,-0.004641019,0.06296235,0.07114164,-0.06487051,-0.023096602,-0.002341968,0.06354278,-0.034285847,-0.011321003,-0.028396362,0.013452822,-0.044437677,-0.108275525,0.009486163,0.02290905,0.027679568,-0.07970945,0.045816917,0.048681762,0.0028091026,-0.024201866,0.054968342,0.032157607,0.07726367,0.045859188,-0.09146396,-0.07111654,-0.08175955,-0.018705567,-0.04700962,-0.068215534,-0.074649975,0.02949185,-0.014582716,-0.043026935,0.08387228,0.0063457033,-0.026324904,0.048372075,0.030606605,-0.004463121,0.0152571015,-0.011254897,0.042288676,0.033636827,-0.0011325448,0.001765307,-0.015709164,0.06073191,0.008521449,0.049449548,-0.048970524,0.0074217967,0.007121394,-0.078382626,0.024040582,0.09376409,0.042794485,0.011160119,-0.024929008,-0.0069255405,0.036484227,0.01711676,-0.026384665,-0.037512664,0.0060074525,-0.014092544,0.13570283,0.04544854,0.043722562,-0.06676449,0.096175864,0.04985871,-0.038322598,-0.013297856,0.02118674,0.04031998,-0.026819415,-0.02280486,-0.043562576,0.023032855,-0.06741119,-0.06272291,0.020005837,-0.057590257,0.044150315,-0.06487925,2.1010525e-33,0.094225526,0.009549518,0.037149508,-0.019639215,0.0152768195,-0.013418904,-0.012431161,-0.05552049,-0.050299745,-0.06762486,-0.0028332346,-0.041028388,0.047612265,-0.013088311,-0.047561787,-0.017437002,-0.07335929,-0.10857521,0.034868408,0.037111152,-0.0035805455,0.05008769,-0.009523966,0.07716257,0.053643048,-0.0001051359,-0.028567731,-0.0031269586,0.0355484,0.020677403,0.0053142044,-0.078215234,-0.08658265,-0.00986224,0.013770194,-0.010378561,-0.010745141,-0.07536127,0.031180944,-0.009116257,-0.08097659,-0.026983345,-0.056074113,-0.05972382,0.0029477673,0.016198888,-0.016259305,0.12521382,0.028310992,0.014855702,0.013661886,-0.015357019,0.00761309,-0.0053818687,-0.08026101,0.03910616,-0.022827774,-0.07127838,-0.020606605,0.10654107,-0.055146202,0.041694712,0.009724647,0.050781574,-0.032539126,-0.043098778,-0.06395768,-0.0478583,0.053557675,0.091903254,-0.077426456,0.0254312,0.00592063,-0.015170645,0.029782554,-0.027340725,0.06139452,-0.122867025,0.038978428,0.014748811,0.047680587,0.049343206,0.066628456,-0.05402401,0.009787603,-0.0074274326,-0.11115718,-0.0362371,-0.06216661,0.09709935,0.030243188,-0.042600885,-0.0030140753,0.0300002,-0.056600235,-3.3427694e-33,0.12035934,-0.10202785,0.10358685,-0.09760227,-0.12165502,-0.0009357917,-0.0069432794,-0.10141152,0.03759044,-0.025840756,-0.046196908,0.016828744,0.059728272,-0.009345919,0.0022742231,-0.035596553,0.021296654,0.06271902,0.017289702,0.0034490223,0.057052027,0.021238672,-0.04002572,-0.051952004,-0.012342901,0.059487637,-0.041677225,0.051824354,0.055083886,-0.017992781,-0.027005512,-0.06155776,-0.06451155,-0.033908773,-0.022412848,0.029453585,-0.03449486,0.023498552,0.03547296,-0.026106033,-0.008873126,0.019556785,-0.022172386,0.029319083,0.060735017,0.0110636605,-0.06103435,0.051174752,0.0449894,0.04504827,-0.001128886,0.0031490442,-0.0087393485,0.015978402,0.023532998,-0.0017574838,0.04123472,-0.009138148,0.023198182,-0.0015033421,-0.0150419315,0.014852671,0.005975956,0.015383922,0.010292971,0.10532089,0.026179327,0.07213455,0.046851713,-0.022263283,0.029927863,0.067235224,-0.06459661,-0.019524368,0.04365271,-0.032140087,-0.09013739,-0.020270305,-0.016419634,-0.016843937,0.015872499,0.061459027,0.022798926,-0.08507115,0.022112977,-0.00855908,0.020372493,0.13261564,0.08835014,0.007846162,-0.07696832,-0.024890773,0.021463241,-0.0011587975,0.05549532,-3.5486728e-08,-0.11578099,-0.066204265,0.02889599,-0.045863256,0.0014370157,0.14740798,0.020756176,-0.05038476,0.0933894,-0.048484612,0.09204962,0.0765433,0.021564323,-0.033547256,0.023836475,0.07630551,-0.062131938,-0.058728285,0.018762032,0.01945229,-0.016862288,-0.012022089,-0.08504842,0.15064825,-0.0042070495,-0.07845505,-0.011464416,0.119284995,-0.07898852,0.060845125,-0.035694573,-0.0036571485,0.034190506,-0.072815664,-0.014115837,-0.042530544,0.018475287,-0.03487251,-0.0013243376,-0.0127438195,0.011677619,0.022566406,-0.0053496948,-0.010253263,-0.014804242,0.029801013,-0.059058715,0.057103407,0.020912265,0.035060573,0.04048749,-0.05284557,-0.048488926,-0.02024545,-0.082635246,-0.051388945,-0.014854608,-0.09117961,-0.03874951,-0.006132706,-0.03380739,0.02256043,0.16203749,-0.01895449 +6.2.1.47,The enzyme ligates medium chain fatty acids (with aliphatic chain of 6-12 carbons) to an acyl-carrier protein. ,384,1.0,-0.019471485,-0.054763854,-0.06625995,0.052728705,-0.006060391,0.06752646,-0.061746936,0.030854298,0.018057816,-0.050787717,0.123038396,-0.0703335,-0.07172146,0.016243543,0.032467812,-0.009973787,-0.042171624,-0.011301485,-0.057714272,-0.10693524,0.008751393,0.010596613,-0.04014959,-0.012654442,-0.01759143,-0.11728679,0.02899465,-0.061304986,-0.010258547,-0.08226777,-0.016317254,-0.1080404,-0.027199376,0.011497394,0.017900463,0.027202515,0.00088677084,-0.08752275,0.093152545,0.0040824353,0.061245088,-0.02436688,-0.0137311565,-0.020856777,-0.0053806384,-0.03598379,-0.042544287,0.093330964,0.022460299,0.018275652,-0.07056654,-0.05867232,-0.060036287,0.016709846,-0.0051347464,0.075819045,-0.08244757,-0.03582525,-0.039887138,0.03744481,0.01549138,0.004265423,-0.020894393,0.02747429,-0.07902153,-0.10408551,0.04538235,-0.021083953,0.024962617,0.0134348385,-0.027613394,-0.11989893,-0.034214657,0.021693414,0.02523541,0.015559682,-0.060621936,-0.10857373,0.06294216,0.014815697,-0.030037008,0.002981135,0.01282561,0.07906318,0.045774378,-0.042539284,0.009610617,-0.0012503702,-0.10032093,0.06355185,0.039068084,-0.044426426,0.023401406,-0.013356575,-0.06060151,0.008144803,0.041610673,-0.009489738,-0.013355381,-0.026876498,0.024286892,0.04864319,0.0071044895,-0.09440557,-0.11607733,0.033125695,-0.06500713,0.0763902,-0.010086061,-0.031124257,-0.010042949,0.010697939,0.028138088,-0.011025428,-0.0073271287,0.083375365,-0.014754902,-0.095088325,0.027388377,0.006633231,-0.06345299,0.0018512855,-0.004221161,0.067475766,-0.020556955,-0.047413424,-0.044669367,-1.7564575e-33,0.045324087,-0.018910846,-0.018550882,0.0035133332,0.0125050945,-0.023845386,-0.101779796,0.037448924,-0.06551006,0.009057626,0.0042139324,-0.060451955,0.0076632607,0.030227888,0.046703875,-0.03815025,0.028253557,0.05940419,0.07000151,-0.015629787,-0.051108852,0.09522188,0.035154324,-0.07078888,0.09437912,0.02569863,-0.040883623,-0.012727584,0.025857143,0.028378999,-0.044275716,-0.028262492,-0.057274573,0.04867569,0.025167717,0.020506961,0.008525944,-0.048238914,-0.046874464,0.0049721794,0.113716274,0.025956905,-0.021418847,-0.036053218,-0.031917095,0.036436908,-0.021492697,0.03770247,0.029876329,0.034647275,0.05573975,-0.027844673,0.09259313,0.010010113,-0.023247471,0.04581863,-0.10459021,0.022532377,-0.03006933,-0.016944867,0.0109527055,0.025075028,-0.059687834,0.04783079,-0.0060144803,0.025859624,-0.10911324,-0.016210629,-0.011678393,0.09051588,0.015493666,0.041696522,0.05217897,0.0008554809,0.026814016,-0.026705153,-0.102660105,0.03008045,-0.0072314288,0.07209992,0.014766708,-0.010333484,0.04102925,0.015659122,-0.048214138,-0.028520592,0.0034277432,0.052073363,0.07540063,-0.009168906,-0.004249016,-0.02866954,0.006378298,0.0919461,0.019486874,-1.3131182e-33,0.09399085,-0.13440421,0.050366316,-0.081499375,-0.035983633,0.015150988,0.07858195,0.025877902,0.015511432,-0.020928763,0.07369546,0.037319034,0.0009196687,-0.07717885,0.04004466,0.0137683395,-0.06205054,0.033303842,0.07962337,-0.005506535,-0.040070727,-0.0718563,-0.02273405,0.09350709,0.051667567,0.060541015,-0.041539136,0.05125795,0.026567359,0.040299937,0.032416385,-0.014189557,0.030620871,-0.04817533,-0.07656026,0.06007958,-0.039779224,0.047475807,-0.008593266,0.043468874,0.01982392,-0.012098893,0.00549678,-0.02913646,0.057937335,0.01865625,0.014634277,-0.052759457,-0.021659732,-0.106476225,0.077358745,-0.04560798,0.07947415,0.008230754,0.016648326,0.11610999,0.009673842,0.053785816,0.07011286,-0.09813871,-0.07352032,-0.053959955,0.008237705,-0.042672195,-0.021694118,0.02917182,-0.019032275,-0.08625539,-0.04248265,0.014407823,0.02632836,0.09843505,-0.010193504,0.045413867,-0.006282191,-0.08698814,-0.04651466,-0.0644924,-0.053922914,0.020498859,-0.029480401,-0.0279486,-0.028523901,-0.022380024,0.03677963,0.009025957,0.04583453,0.042500004,0.01730624,0.0850352,-0.02737111,0.011133266,-0.028614119,0.010114802,0.02081985,-2.6722088e-08,0.049158633,-0.06449659,-0.0050159167,-0.056878746,-0.08021885,0.06792944,0.021944106,-0.031219937,-0.00032792517,-0.03732207,0.0038552599,0.07502225,0.038581427,0.08452488,-0.028573645,-0.048271097,-0.05661586,-0.012800653,0.04617239,-0.044042323,-0.11002074,0.009483612,0.006628215,0.04115981,-0.013603677,-0.007715341,0.03585778,0.041998003,0.018496,0.0406742,-0.010709247,0.034530025,0.026942357,-0.0070561897,0.021599198,0.04496542,0.0352164,-0.06951146,-0.06572979,0.11150486,0.08091812,0.008278927,-0.049819805,-0.0061805495,0.06856711,-0.0313558,0.010526362,0.055759892,0.0036308775,0.0634722,0.060236696,0.0139116645,-0.082683094,-0.01880606,-0.024851233,-0.0985938,-0.015282,-0.10514002,-0.04263866,0.003961576,0.046827424,0.025622943,0.21789692,-0.046330024 +1.5.3.23,"The enzyme, characterized from the bacterium Ochrobactrum sp. G-1, contains an FAD cofactor. The catalytic cycle starts with a reduction of the FAD cofactor by one molecule of glyphosate, yielding reduced FAD and a Schiff base of aminomethylphosphonate with glyoxylate that is hydrolysed to the single components. The reduced FAD is reoxidized by oxygen, generating water and an oxygenated flavin intermediate, which catalyses the oxygenation of a second molecule of glyphosate, forming the second pair of aminomethylphosphonate and glyoxylate.",384,1.0,-0.08600837,-0.0435697,-0.089743294,0.020083645,0.111843415,0.007272837,-0.020500109,0.028711095,0.003935396,-0.009654315,-0.0033276118,-0.013335393,-0.07179357,-0.04674738,-0.081941664,-0.01507153,-0.095805705,-0.025161196,0.005723037,-0.004046893,0.059521258,0.037767593,-0.011995618,-0.05331731,0.08078674,-0.0018151171,0.0008243273,-0.031416398,0.0263824,-0.05601081,0.081805564,0.025605144,0.0604245,-0.067897804,0.04507149,0.06091354,0.067807235,-0.065572515,0.033908814,0.022571074,0.011555977,0.042656396,0.010620358,-0.03679126,-0.043515965,0.018912924,0.026070297,0.061937135,-0.014992156,-0.008283749,-0.03156871,-0.106964745,-0.11502919,0.02675419,0.034776047,0.054422818,0.01639241,-0.07305026,0.0077973106,-0.010999929,0.027773473,-0.002341017,-0.014792976,0.051636983,0.01947619,-0.07380739,0.068786345,-0.1042654,-0.009339772,-0.030832557,-0.02440075,-0.012102044,-0.017048055,-0.018768232,-0.038790617,0.060067557,-0.054287817,-0.04156968,0.08439229,0.017261222,0.009965546,0.020261819,0.091112845,0.082977965,0.015959265,-0.04167335,0.023143273,-0.03973402,0.028033327,0.033987522,-0.018317085,0.016466478,0.025243936,-0.08922332,-0.100266635,0.05836136,0.08701127,0.030748788,0.03699664,-0.0056762164,-0.07507099,0.028794583,0.044966284,-0.10605429,-0.08966227,0.0010117405,-0.037137993,0.09305962,0.047960937,-0.006934708,-0.047511335,0.029909344,0.04283473,-0.029279241,-0.04982055,0.053154916,0.054810334,-0.082072474,-0.051718358,0.037170913,0.022587033,-0.06017883,0.09613952,0.011747087,-0.04748764,0.00701885,-0.09065907,5.849792e-33,0.102245726,-0.001024293,-0.010472583,-0.0461809,0.016527902,-0.035164326,-0.120121814,0.01586601,-0.039386302,0.004189105,-0.041391503,0.0014674425,0.022552554,0.0033448357,0.014060496,-0.01987132,-0.051504742,-0.026035337,0.018988304,-0.060770124,0.04308396,0.060584188,-0.022058807,0.031649906,0.07536241,0.05200081,-0.0033690939,-0.013214806,-0.045058753,0.011153597,0.030367827,-0.06460634,-0.13392004,0.011701848,0.031912606,-0.0077242856,-0.048901804,-0.051359665,-0.024190165,0.04370576,0.011780336,0.003547289,0.018855296,-0.031936254,0.08399353,-0.021634916,-0.043922838,0.07109747,0.06680002,0.1226385,0.037497394,-0.014365431,0.036074236,0.046988443,-0.074781954,0.06703912,-0.014039399,-0.07740452,0.03575373,0.020165805,0.03256808,0.06302636,0.011054256,0.034810364,-0.022907952,0.010809192,-0.031010652,-0.06700964,0.09993347,0.069116496,-0.042800114,-0.065108016,0.031124348,0.03014712,0.019508455,-0.07382243,0.0579969,-0.051789377,0.026801035,-0.010966634,-0.009046234,-0.013546717,0.0007392255,-0.09320813,-0.0078166975,-0.05051575,-0.07709981,-0.055152126,-0.03585412,0.020444002,0.010709397,-0.09204278,-0.021132974,-0.027243868,-0.013438007,-6.361442e-33,0.10489918,-0.12425828,0.030254155,-0.05604066,-0.060277425,0.04871249,0.026594426,0.007394446,0.018114131,-0.007767752,0.015895907,0.023042895,0.06234456,0.027671369,0.0061286297,-0.035794772,0.049281307,0.015757913,0.009049272,0.029240614,0.0031141841,0.03314831,0.02699252,-0.037167437,0.03793258,0.029145403,-0.030637741,0.0030132784,0.043919463,0.06978659,-0.038188707,-0.001641705,-0.013056506,-0.04585324,-0.08908301,0.019497056,-0.015313306,-0.03555979,-0.013903694,2.7482252e-05,0.07508535,0.008422005,0.026871422,0.030658616,0.024004519,0.012833941,-0.10655773,-0.016096609,0.00454579,-0.076083854,0.057801433,0.03480664,-0.039265815,0.029926326,0.023497893,0.037749723,0.07983305,-0.003375192,-0.09592978,0.03900709,0.008707234,-0.05394406,0.035475608,0.02539646,0.09927354,0.062125523,0.02430856,0.058689468,-0.023989603,0.0020599018,0.03512701,0.030076368,0.026827922,0.060264096,0.047640685,0.009421243,-0.057650216,-0.006251667,0.007085979,-0.03599707,0.048166256,0.019105017,-0.047902767,-0.017286098,-0.057691976,-0.09701927,0.009718959,0.08296562,0.03242875,0.06207714,-0.06975481,0.04507141,-0.00062829093,0.076265484,0.10017182,-4.212163e-08,-0.05434255,0.00315221,0.09385287,-0.038037207,0.049355805,0.060890958,0.011849922,-0.067175575,0.013710214,-0.0858727,-0.016116975,0.13711192,0.020436337,-0.025967171,0.045545083,0.041530237,-0.10456845,-0.035447717,-0.05999536,-0.0064960276,-0.030135354,0.03380663,-0.09426102,0.05159776,-0.009838566,-0.041326206,0.029924557,0.059453808,-0.020785283,0.00717269,-0.03360853,0.069968216,-0.026704337,-0.038232937,-0.12927972,-0.04138644,0.00040668243,-0.051939346,-0.049108673,-0.0029095553,-0.014659113,0.058850866,-0.095328845,-0.022057224,-0.009261678,0.0548745,0.0017689016,-0.027142892,-0.07976722,0.060619626,0.035546616,-0.0011371898,0.009565491,-0.013711556,-0.15273735,-0.018131891,0.021214437,-0.042207304,-0.065820664,-0.02372403,-0.029505866,0.0067671556,0.1640974,0.04574797 +1.8.5.5,"The enzyme, characterized from the bacterium Salmonella enterica, is similar to EC 1.17.5.3, formate dehydrogenase-N. It contains a molybdopterin-guanine dinucleotide, five [4Fe-4S] clusters and two heme b groups. The reaction occurs in vivo in the direction of thiosulfate disproportionation, which is highly endergonic. It is driven by the proton motive force that occurs across the cytoplasmic membrane.",384,1.0,-0.028486026,-0.030964404,-0.071453854,-0.027818128,0.05599785,-0.0025010195,-0.04542502,0.07451557,0.050979216,-0.051649697,-0.017604973,-0.065753385,-0.09604914,0.026506389,-0.06039382,-0.04597472,-0.047739428,-0.0319727,-0.021356164,-0.095785685,0.013570137,0.03788333,-0.002115082,-0.03492302,-0.045733575,0.048692115,0.09228923,0.03404586,-0.040337816,-0.11970137,0.016377542,-0.046300218,0.079648025,-0.034467086,0.042215865,0.1158867,-0.011066851,-0.056325775,0.06842966,0.014909515,0.048354432,0.04523573,-0.033577174,-0.008725107,-0.0025023327,-0.017665748,-0.008151026,0.04572075,0.042732496,-0.0020917703,-0.040868834,-0.057029292,-0.011244476,0.029322095,0.014018646,-0.013503005,-0.039324522,-0.026882092,-0.015714865,-0.045649845,0.0468444,0.008510577,0.06711836,-0.000324759,0.012886437,-0.045971654,0.12344625,-0.09904605,0.008600892,-0.09544106,-0.052639134,-6.564732e-05,-0.063998155,0.035342526,-0.09480287,0.05742208,-0.00983289,-0.03813898,0.07808017,-0.0022165831,0.03268781,0.02646184,0.030056143,0.08207345,0.024769431,-0.01961917,0.027507735,-0.007511148,0.06607377,0.048038796,0.03299558,-0.036508698,-0.0050855256,-0.046212655,-0.06727244,0.032831416,0.011537877,0.03646285,0.048534833,-0.02160075,-0.026901558,0.082623184,-0.059417408,-0.05625336,-0.020574689,-0.022316735,0.043721437,0.10297322,0.03382393,-0.00073916704,0.009575765,-0.016966054,0.052644953,0.013654549,-0.0072963834,0.03364498,0.03136345,-0.071792245,-0.005536116,0.010937473,0.03946422,-0.0692267,-0.0014763292,0.054061633,-0.027080147,0.05091176,-0.113376305,2.7142016e-33,0.043661416,-0.02077343,0.037383955,-0.059868757,0.02400516,-0.03409184,-0.08186575,0.07844618,-0.09547752,0.028678916,-0.1024309,-0.07671242,0.08281027,-0.014817245,-0.025261912,-0.027446749,-0.038700107,0.04343199,-0.05180008,-0.0047411504,0.03970725,0.029235194,-0.0035398148,-0.019310694,0.025212748,0.04323374,-0.034848176,0.033448454,0.11561243,-0.022833103,-0.0056738122,-0.13184592,-0.10999482,-0.0017553495,0.07220889,-0.021892391,-0.023102723,0.0012323862,0.0034533706,0.040078472,-0.05522014,0.054641683,0.005421817,-0.043140206,0.067675084,-0.051154952,-0.0111227445,0.03590208,0.06434648,0.023895582,0.017651817,-0.035837937,0.120245,-0.09962117,-0.0011326637,0.02036455,0.018650355,0.03261955,0.032331176,0.060187772,0.011752299,0.06884844,-0.05967718,0.02282737,0.021686109,0.033651292,-0.024338469,-0.04275438,0.058761436,0.06031249,-0.06386483,-0.013906873,0.051396295,-0.03047614,-0.054838452,-0.030356672,-0.06858772,-0.068178095,0.06546073,-0.0177008,-0.037306394,-0.004093775,0.026032194,-0.04131215,-0.07545924,0.05517297,-0.057651818,-0.040072322,-0.0009027381,0.068759225,0.046164706,-0.049546055,-0.07436248,-0.0065797903,0.03339405,-3.4901706e-33,0.06174701,-0.044321466,-0.005932051,-0.11034253,-0.07428643,0.09879497,0.011086245,0.052032616,0.06587191,0.010275919,0.0963186,0.010799719,0.029578954,-0.045380685,0.026087077,0.0441806,0.023002286,0.06653335,-0.036323745,-0.056554988,0.030004442,0.02535962,0.015331368,0.010518381,0.054894913,0.018480372,0.02270418,0.045126677,0.028019885,0.035104264,-0.049337868,-0.012913341,-0.016012063,0.0019809217,-0.035175025,0.0070172455,-0.04427256,0.0008847505,0.05658647,-0.020210728,-0.03973137,0.054157052,0.057701234,0.15009959,0.012926472,0.09521456,-0.07863248,0.031267,0.034920428,-0.02764557,-0.039757393,-0.03568513,-0.020639295,0.03620699,0.0014972396,0.035052918,-0.00797133,0.0025116717,-0.07756092,-0.019893449,0.0066324235,-0.121886685,0.07766376,-0.036988977,0.029527374,0.013780592,-0.08302201,0.022109875,0.04841514,-0.041219406,0.023210306,0.018362788,-0.029854247,0.012761112,-0.03171195,-0.06381646,-0.0074287,-0.01853031,0.035193656,-0.013472607,0.03949962,0.035695292,-0.06653197,-0.10724127,0.026582029,-0.05705597,0.020660657,0.12145707,-0.01483828,0.062214144,-0.037972108,-0.019083116,-0.02850944,0.016973514,0.008322606,-4.6038135e-08,0.03710043,-0.11781597,0.06086657,-0.041423015,0.022955129,0.07909278,0.0023694236,0.0015516146,0.052897185,-0.04051557,0.03637034,0.094938815,-0.0053183134,0.005094972,0.026555803,0.07236307,-0.03296452,-0.013249226,-0.008343912,-0.0060412944,-0.03775886,-0.047833726,-0.12315049,0.024319986,0.04270416,-0.018974388,-0.013588355,0.01620747,-0.045304723,-0.021284143,-0.06127883,0.019809118,0.015620917,-0.0021318581,-0.033439066,0.03390845,-0.058881655,0.029171348,-0.063996695,0.028376484,0.05705297,0.027434137,-0.10183818,0.0026258274,-0.020519163,0.06038423,-0.010700149,0.08226934,-0.05969756,-0.009633699,0.06814529,-0.06187933,0.021967186,0.014221224,-0.10235675,0.018725842,-0.04665923,-0.119019285,-0.013752387,0.01304309,0.09242311,0.025706928,0.18245001,0.0107994145 +1.8.5.6,"This membrane-bound bacterial enzyme catalyses the direct oxidation of sulfite to sulfate in the cytoplasm. The enzyme, characterized from the bacteria Ruegeria pomeroyi and Allochromatium vinosum, is a complex that consists of a membrane anchor (SoeC) and two cytoplasmic subunits: an iron-sulfur protein (SoeB) and a molybdoprotein that contains a [4Fe-4S] iron-sulfur cluster (SoeA). cf. EC 1.8.2.1, sulfite dehydrogenase (cytochrome).",384,1.0,-0.09036787,-0.017658351,-0.1296241,0.008410033,0.015192272,0.037515443,-0.026196284,0.05716404,0.05018894,-0.08011156,0.005002681,0.026516648,-0.04373005,0.004537868,-0.08129305,0.009697528,-0.061140638,0.040921476,0.016847169,-0.044129904,0.073195636,-0.019191127,-0.040798992,-0.05712072,0.004634412,0.098342285,-0.02175836,0.0072464375,-0.0876611,-0.052452676,0.0019231497,-0.007545021,0.046433125,-0.057704877,0.04461576,0.06617991,-0.0038113107,-0.05265545,0.025719956,-0.026713371,0.010735694,0.07094318,-0.043599114,-0.030550493,0.01036211,-0.0029511373,0.027045185,0.049208164,0.037885178,-0.09383229,-0.022636564,-0.022428185,-0.03142003,0.022844698,-0.012308533,0.03803669,-0.026408313,-0.02930242,0.00868264,-0.037653353,0.012620686,0.002674711,0.06897662,0.013182657,0.030590454,-0.028252495,0.0733606,-0.06922266,-0.0016174914,-0.03444952,-0.083262734,-0.020006686,-0.054081686,0.06773482,-0.031901896,0.06119958,0.0068604094,-0.020009376,0.058042273,-0.038205635,0.0072242767,-0.0013104366,0.005885849,0.10526484,-0.0057231956,-0.04560232,0.03727328,-0.037902344,0.0873051,0.07270836,0.015609856,-0.0164289,-0.043598868,-0.028493972,-0.07710009,-0.006681426,0.031559236,0.12053285,0.003572491,-0.043228414,0.020808354,0.024293436,-0.015047698,-0.09106353,0.0058725374,0.0039215544,0.017525883,0.10582799,0.016254855,-0.03057344,-0.0035462559,-0.024424471,0.030688053,-0.03491643,-0.0020599118,0.08369691,0.1379328,0.011392515,-0.07808551,0.032609824,-0.029614097,0.009730353,-0.037289176,0.06032818,-0.029322969,-0.009929324,-0.1851284,-6.503467e-36,0.057024166,0.026085308,0.04461637,-0.055662088,-0.056041397,-0.038125835,-0.05929971,0.016872194,-0.01068009,0.04865912,-0.095136024,-0.065517515,0.026971413,0.0031471243,0.008184036,0.023502598,-0.034124892,0.0062007955,0.06326722,-0.04811474,0.025630003,0.0023694073,0.004701591,-0.107532986,0.09076362,0.029278668,0.024764342,-0.056088906,0.016538588,0.0015640325,0.07384905,-0.14478625,-0.064004146,-0.030724185,0.08986454,-0.028638454,-0.0029495344,-0.015525207,-0.023572423,0.0014640138,-0.073007025,0.014101828,0.014630703,-0.013686852,0.0015135456,-0.07871086,-0.08047552,0.11977132,0.05909847,0.03566217,-0.008183848,-0.05050849,0.050748557,0.011421907,-0.08086273,0.030598475,0.007468298,0.016034674,0.020937942,0.08436865,0.07123914,0.06891255,-0.0947885,-0.0054621464,0.07657654,0.035048727,-0.03531253,0.028171372,-0.0004341095,0.07958276,-0.10574182,-0.01609362,0.03495988,0.029783204,-0.050325435,-0.005560958,-0.01882247,-0.016936798,0.034446575,0.03874174,-0.05288859,-0.0728608,0.001429054,-0.053846054,-0.020893881,0.023732798,0.0050442205,0.005614646,-0.061947435,0.03211813,0.03783337,-0.045750115,-0.055565976,0.0032515673,-0.038375888,-2.6678963e-33,0.06382792,-0.07386713,0.07415306,-0.12736821,-0.042264238,0.050957654,-0.029874485,0.028124193,-0.01687718,0.05197854,0.005390329,0.00961779,0.04766553,-0.03571615,0.017893381,0.037530046,0.009554105,-0.012367486,-0.027474562,-0.019372554,-0.034564454,0.08532523,0.039107814,0.052245673,-0.025271378,-0.03671432,0.013454442,-0.0031960253,-0.0047679576,0.09948722,0.013349974,0.003953048,-0.037352398,-0.064508334,-0.02120327,0.032390084,-0.04460943,-0.0015256196,0.07726152,0.0066458923,0.0067953803,-0.06401933,-0.019373855,0.10023301,0.0452408,0.025037626,-0.08885428,0.04314973,0.010923875,0.028478649,0.031610865,-0.0063722352,0.05449332,0.026596656,0.036939513,-0.00017641316,0.013132634,-0.028275574,-0.059928183,-0.034014527,0.0005764594,-0.07614151,0.0073182317,-0.04177785,0.026109403,0.065044396,-0.024154454,-0.08272623,-0.004465247,-0.04388878,0.008860977,-0.031267043,-0.06579747,-0.008965668,-0.059286036,-0.01449098,-0.03943667,0.062349677,0.008081808,0.030200804,-0.0071649635,0.028711092,0.0021344295,-0.06745331,0.12267194,-0.06489015,-0.011640804,0.17236239,0.052605156,0.018153267,-1.3016336e-05,-0.01808399,-0.04619857,-0.012544966,-0.05725874,-3.5967346e-08,-0.005739649,-0.037826538,0.0654081,0.015123771,-0.018871285,0.0651287,0.04037352,-0.037167538,-0.0055988804,0.015424902,0.059273243,0.1511342,-0.04282811,-0.026233928,0.07920727,0.0585127,-0.06669103,0.020455087,0.02808478,-0.031980783,0.006829141,-0.053483874,-0.11248322,0.07514331,0.110715,-0.075870536,0.055006854,-0.055422094,-0.046948854,-0.007252793,0.061358493,0.002600054,-0.04615821,-0.016266542,-0.027170645,0.00293501,-0.020499682,-0.03533922,-0.007346352,0.034493778,-0.026797257,0.03143968,-0.066811025,0.018212061,0.027783921,0.06291646,0.02099288,0.058255047,-0.059074413,0.013616493,0.04714329,-0.04159255,0.018819692,-0.03402982,-0.12325532,0.07886959,0.05463917,-0.08120795,0.004702634,0.043592393,0.04226021,-0.038348295,0.13335004,-0.018056579 +1.10.3.16,"Requires FMN. The enzyme, isolated from the bacteria Pseudomonas fluorescens 2-79 and Burkholderia lata 383, is involved in biosynthesis of the reduced forms of phenazine, phenazine-1-carboxylate, and phenazine-1,6-dicarboxylate, where it catalyses multiple reactions.",384,1.0,-0.027887816,-0.015666105,-0.13267562,-0.0047037792,0.045564953,0.06450009,-0.094376676,0.06305165,0.0062357574,0.018842926,0.02349352,-0.056508794,-0.0692608,0.034418724,-0.057479363,0.012406043,-0.12432825,-0.003262648,0.007362406,0.07743198,0.06296522,0.0962043,-0.020142017,0.044484377,-0.027494853,0.01636064,0.107550606,-0.016311504,0.03865761,-0.05553145,0.004287992,-0.030408308,0.1121513,-0.012022253,0.027945813,0.032128736,-0.012382108,-0.032696597,0.1111548,0.017359825,-0.024949152,0.0047645024,-0.017617028,-0.116743945,0.0045750155,-0.01392121,0.031720046,0.04873113,0.03381281,0.00051565765,-0.05837606,0.026471801,-0.008923637,0.07494117,0.014075256,0.00034465542,-0.043347552,-0.04081947,-0.05487482,0.09782929,0.02540521,0.037466522,-0.034121666,-0.042277798,0.055058874,-0.016529553,-0.050022874,-0.028877169,0.042901553,-0.026630037,-0.048672754,-0.059438854,0.059240088,-0.035211775,0.055043433,0.03920765,0.034612074,0.01722428,0.0015379359,-0.0641903,0.020875795,-0.08312055,0.005432472,0.04038501,0.022932457,-0.047609426,-0.019548558,0.07919277,0.12941097,0.020424204,0.0011390965,0.037364494,-0.0032692503,-0.07452522,-0.0753897,0.05983771,-0.0038233285,0.06528905,0.0676452,0.025044033,0.006212375,0.025558127,-0.005033265,-0.07498582,-0.063416936,-0.03763312,0.07639315,0.040132526,0.027520116,-0.02174406,-0.029992618,0.01147919,0.026619317,-0.051219095,-0.06771699,0.04701586,-0.017578099,-0.12914965,-0.058028966,-0.012552005,0.014399219,-0.072104,0.011486942,0.07125182,0.026682133,0.0016530291,-0.1589403,3.1825415e-33,0.051265437,0.098646104,-0.0067196563,-0.012339507,0.0014940306,0.006320801,-0.032643564,-0.012078496,-0.019745862,-0.1094881,-0.022333665,-0.030950703,-0.0048402096,-0.036955394,-0.0363269,-0.048298486,-0.016593996,-0.024794258,0.08606314,-0.006183495,0.05418111,0.033901934,-0.06274862,0.039293118,0.07698944,0.084370576,0.03154512,0.013760457,-0.0077961134,-0.023033515,0.05515996,-0.06286557,-0.054651313,-0.01019149,0.09313034,-0.024349382,-0.11106906,-0.01781597,-0.06284448,0.040896766,0.06771189,0.023841294,-0.040497277,0.039428137,0.06426251,0.008450684,-0.04810853,0.0970682,0.030600922,0.06851392,0.008721274,0.025809377,0.032118574,0.0017749908,-0.02864461,-0.016348764,-0.06167804,-0.05662517,0.058094125,0.0344587,0.008222902,0.046784516,-0.0736735,0.07716062,0.025779575,0.0015441085,-0.031430434,0.013165423,0.05708945,0.05946879,-0.030991549,-0.036526904,0.011803181,0.025999662,-0.0028662658,-0.013334738,-0.0025578043,-0.036003668,-0.02923176,-0.03212911,-0.0028809202,-0.021309273,-0.0122022545,0.022920175,-0.08636235,-0.03210505,-0.048301354,-0.028642619,-0.038001426,-0.021226112,0.08074731,-0.108664334,-0.028571678,0.019073792,0.0051283366,-3.437218e-33,0.02591665,-0.073026165,0.034645453,-0.034060292,-0.020125931,0.058826733,-0.03911252,-0.05475204,0.0032303839,0.009133413,0.013128904,-0.03459504,0.05218171,-0.05806956,-0.009790525,0.029439216,0.10631813,-0.0031580245,0.017599827,0.0018588586,-0.008882568,0.11975276,0.002106138,0.00881877,0.029397737,0.07534718,0.012256217,0.12389992,0.045047954,0.07741669,0.004036459,0.019188864,-0.015461675,-0.0732097,-0.005675362,0.04939212,-0.027720975,0.006651286,0.021992268,-0.01888443,0.027356049,-0.0030796623,-0.018347587,0.021895045,-0.02675906,0.06205465,-0.023912432,-0.010053429,-0.0053781746,-0.036302947,0.02996535,0.03423294,-0.044776667,-0.07322621,0.009521544,-0.021220429,-0.010646947,-0.019757617,0.032292973,-0.018407542,0.013139109,-0.12180856,-0.02078457,-0.053694423,-0.008959548,-0.011116233,0.046611518,0.10802879,0.058777146,-0.027528774,0.059971493,0.04685836,0.06661458,0.08685998,-0.11457109,0.09459191,-0.03553403,-0.07361158,0.035977527,0.05095795,0.03252979,-0.06338074,0.041115243,-0.07017035,-0.017900625,-0.026149314,0.03185915,0.03369587,-0.014683924,0.03884264,0.032694314,-0.0187851,0.067018345,0.030048676,-0.0128377415,-3.810979e-08,0.06376344,-0.12634099,0.023541622,-0.049831036,0.008424204,-0.0006865414,-0.026698133,-0.0015121907,-0.03911796,-0.044600997,-0.02926391,0.011169646,-0.011637714,0.0051799053,0.06986169,-0.019430846,-0.05952474,0.081133954,-0.092166916,-0.006665189,-0.0915514,0.012921913,-0.13934496,0.01205422,-0.0065337582,-0.021070553,0.028579505,-0.05122176,0.055974107,-0.024219908,0.015959814,0.04517825,0.03842233,-0.022857087,-0.14998236,-0.05744706,-0.0001897383,-0.029260846,-0.11351129,-0.017123487,0.07471516,-0.013272985,-0.059603877,0.019507546,-0.057700302,0.019645236,-0.004914854,-0.01795542,0.006336633,-0.06921937,0.035956476,-0.008818833,0.0068699727,0.009242558,-0.09637165,-0.017090596,-0.008847464,0.005357372,-0.02143692,-0.026867703,-0.044765394,0.06600093,0.17251955,0.04808991 +1.14.12.25,"The enzyme, characterized from several Pseudomonas strains, is involved in the degradation of p-cymene and p-cumate. It comprises four components: a ferredoxin, a ferredoxin reductase, and two subunits of a catalytic component. The enzyme can also act on indole, transforming it to the water-insoluble blue dye indigo.",384,0.99999994,-0.03473531,-0.05760578,0.005267774,-0.0048107253,0.04618512,0.07387282,0.0058435625,0.053071182,0.018022995,-0.037982687,-0.032644473,-0.010854436,-0.051652882,0.09960615,-0.07356363,0.0394031,-0.08481728,-0.0061780713,-0.0013199543,-0.023188256,0.039428446,0.045224592,-0.023188803,0.008986052,-0.002322148,0.045269415,0.069729194,0.016521677,-0.045592867,-0.020081732,-0.043679364,0.026749227,0.112576924,-0.07217686,0.046372455,0.067091435,-0.040419653,0.0024895403,0.09543727,-0.054519694,0.09167415,-0.018926136,-0.022196466,-0.08003533,0.011955136,0.02707247,0.03295996,0.018428154,0.043210633,-0.062635444,-0.05399443,-0.07874585,0.0066212066,0.0740408,0.027519196,0.0037453084,0.034600347,-0.052661445,-0.07040815,-0.004411489,-0.014238599,0.030258732,-0.082737975,0.032418836,0.08621656,-0.007555608,0.044772718,0.0024084796,-0.027435608,0.0034642832,-0.058608525,-0.047501262,-0.02476059,0.027394492,-0.009885199,0.009359054,0.017569894,-0.031010006,-0.045180064,-0.081303716,0.057405043,0.0048052534,0.02686243,0.07927964,0.040511426,-0.019426588,0.025785979,-0.026925797,-0.011616078,-0.032125387,0.012701208,0.027786525,-0.0038781068,-0.06267862,0.012625196,0.044355035,0.018748244,-0.048496652,0.102851614,-0.020811982,-0.020600952,0.04616642,-0.012056133,-0.18330546,-0.07671053,0.011452614,-0.051606804,0.08244157,0.12106645,0.035804834,-0.026107991,-0.07406933,0.053519152,-0.061873943,0.008734993,0.024933793,0.04353764,0.048420716,-0.068300016,0.039456416,0.011164268,-0.048358813,0.056195803,0.09128515,-0.013502127,-0.02462523,-0.10124694,-7.3144727e-34,0.09173234,-0.026738595,-0.024352025,0.018789371,0.064654686,0.052808736,-0.011115679,-0.046204433,-0.02103292,-0.08370601,0.005331287,-0.07195624,-0.022457497,-0.036595467,0.006780306,-0.025687061,-0.03805376,-0.0118045015,-0.0014350137,0.015299796,0.015651077,0.047210585,-0.082554884,0.030614479,0.021498377,0.05382013,0.033759363,0.064569496,-0.05735057,-0.043578792,0.053487144,0.017180126,-0.15694228,-0.017175214,0.011947515,-0.07087012,-0.05079607,-0.03998384,-0.048001975,0.050865006,-0.029989813,0.010583403,0.022103569,-0.036716137,0.037971277,-0.07538521,-0.058104154,0.15035532,0.07469148,0.098065265,0.047340363,-0.041855186,0.07578727,-0.023307484,-0.08451256,0.028605448,-0.020324027,0.0050410037,0.049445108,-0.008828312,0.1087855,0.012272466,-0.03847112,0.00034209696,-0.020127263,0.02173506,-0.027445571,-0.0038100404,0.031213056,0.07225576,-0.10687378,-0.0013931624,0.023195498,0.011351431,-0.02567438,-0.08002433,-0.061642163,-0.016900174,0.05276305,0.0338219,-0.048477385,-0.04930566,0.013755792,-0.0033538397,-0.06784397,-0.00033059853,0.038910076,-0.0061258175,-0.026858196,0.0033595897,0.058574412,-0.14828472,-0.07819062,0.038962275,-0.008830529,-1.3427005e-33,0.06482823,-0.055803012,0.04078335,-0.028372742,-0.042376786,-0.015875397,0.03183451,0.06311971,-0.019827439,0.0031655175,0.0624434,0.032367323,0.040952295,0.011522918,0.050697938,0.05445067,0.017546322,0.039977204,0.009651608,-0.015680827,0.015416408,0.05879337,0.009784282,-0.0046615535,0.051105205,0.030758461,-0.035136368,0.095969446,0.10134822,0.08160281,-0.0053483928,0.07782135,-0.080129646,-0.02578532,-0.04459583,0.049754523,-0.021301622,-0.013589128,0.062365554,0.03761512,0.049419228,0.032675587,0.027716942,0.05900498,0.011004678,0.076054685,-0.038474917,0.03716313,0.014379088,-0.0510774,0.01080735,0.0333388,-0.042708028,0.018558146,0.007624754,-0.010854849,0.028563833,-0.037477583,-0.025727868,-0.021498248,-0.066793606,-0.099850595,0.05934881,0.07662364,-0.03802485,0.027152486,0.010109336,0.05885804,0.016780568,-0.026554372,0.07699279,-0.012982183,0.0711418,0.021890821,-0.057127148,-0.04455731,-0.043232027,0.018745631,-0.0144447265,0.019461704,0.032360177,-0.013865745,-0.0702699,-0.072471745,-0.03167925,-0.112260304,0.031946864,0.097699866,-0.007414306,-0.05440067,0.021631712,0.03529567,0.030258484,0.011573335,0.06145401,-3.7956717e-08,0.029862588,-0.094303876,0.079172485,-0.034372225,0.058582943,-0.02429828,0.013468059,0.052371133,0.04197685,-0.041951396,-0.047204074,-0.00058745284,-0.06939364,-0.0160119,0.023899978,0.035010826,-0.06996148,0.020396242,-0.0502721,-0.027561633,-0.078007504,-0.04454694,-0.15066572,0.05639254,-0.017280096,0.007971131,0.043052,0.00012615901,-0.034638286,-0.052022494,0.013224312,0.07522513,0.026197085,-0.010575158,-0.1333912,0.030680066,-0.032683462,-0.010695855,-0.06389467,-0.027457582,-0.0066476865,-0.097816564,-0.08820367,-0.03238402,0.061153468,0.008351374,-0.0394489,-0.0027053135,-0.01664143,-0.035959437,0.067579806,0.008333402,0.01753851,-0.0173457,-0.050802007,0.018769823,0.047018986,0.02233213,0.021398308,-0.00796563,-0.025487646,-0.0025626821,0.16022125,-0.052341055 +1.14.13.228,"Although believed to occur in plants, the enzyme has so far been characterized only from the rice blast fungus, Magnaporthe oryzae. The fungus strategically deploys the enzyme to hydroxylate and inactivate endogenous jasmonate to evade the jasmonate-based innate immunity in rice plants.",384,1.0,-0.06963465,-0.014609822,-0.034701545,0.005695375,0.101286344,0.07535098,-0.077788785,0.01668571,-0.010879821,-0.017847463,0.11148957,-0.0059958883,0.043726727,0.028699476,-0.0615485,0.07676008,-0.031960525,0.047219202,-0.062934846,-0.06012878,0.01767029,0.06351867,-0.006030116,-0.022111919,0.02337327,-0.056056622,0.065132774,-0.017003044,-0.0042609633,-0.11892075,-0.05431183,0.020245021,0.04032457,-0.04584925,-0.015302283,-0.012872969,0.01623736,-0.034988746,0.0624519,-0.069721274,-0.018488912,-0.087304235,0.021006254,-0.056223307,-0.0330335,-0.022498058,0.001650519,-0.061107386,0.09239423,-0.010641657,-0.06285231,0.0008157659,0.052355938,0.040130626,-0.004162606,-0.037642375,0.029516539,-0.009424835,-0.048416324,0.051600963,-0.010839503,0.0325941,0.021095956,0.015981143,-0.028531134,-0.054524638,-0.024524145,0.026856033,0.029570071,-0.056692526,-0.013922187,-0.05938132,0.045595333,0.04832688,0.0071639554,0.0730723,0.013574197,0.015003468,0.067784324,-0.007903859,-0.018146114,0.01298978,0.10281179,0.03347452,-0.0031080523,6.562998e-05,-0.06148784,0.051020864,0.079358794,0.08973975,0.044031657,0.011238708,0.004277668,0.031000359,-0.04432683,0.065755345,0.041583598,-0.048681285,0.0073509137,-0.013370312,0.023022134,-0.006045521,-0.053430256,-0.051305365,0.008282705,0.016232576,-0.026376985,-0.05041858,0.025315257,-0.0090096025,0.05946117,-0.018298648,0.013037484,-0.06641667,-0.04581682,0.028438402,0.04521047,-0.01007446,-0.070018314,-0.10902231,0.051051624,-0.018991718,-0.005040294,-0.016672455,-0.033874754,0.09877747,-0.058093652,2.5323809e-33,0.08537843,0.04220282,-0.026619157,-0.0054144086,-0.045944363,-0.108906664,-0.040904004,0.04773073,-0.03346481,-0.053726584,-0.1104206,-0.055948365,-0.02175224,-0.017486976,-0.05302941,0.0432927,-0.026661804,-0.12206729,-0.026335621,0.06348634,0.026760794,0.008411156,-0.04972075,-0.024825456,0.025401924,0.043401122,0.039774574,-0.039251667,-0.03167426,0.003736634,0.03715339,-0.07583768,-0.088864885,0.074014306,0.059088055,0.020301396,0.0046366644,0.00023512222,-0.07314129,0.001402792,-0.0063538267,0.07190615,-0.0539662,-0.062498793,0.10393337,-0.066294104,-0.011819054,0.040689908,0.042457446,0.061612103,0.011525478,0.021744283,0.11604102,0.01410334,0.08512429,-0.013859997,0.0353961,0.0050315084,0.008869415,0.061408006,-0.066215,-0.028081097,-0.036325272,0.08086028,0.0125903115,0.018062958,-0.08047598,-0.071813956,-0.027071455,0.07540199,0.020415522,-0.0714003,-0.075957954,0.02335472,-0.029387118,-0.10708701,-0.020786554,0.010513101,0.002619165,-0.0007521563,0.08624015,-0.022584312,0.026222406,0.028984975,-0.08687848,0.060258776,-0.038018882,-0.008629522,-0.01114159,-0.014260653,0.11275938,0.041436244,0.0321425,0.04116006,-0.007191596,-3.249059e-33,0.050367642,0.0017551272,-0.013327908,-0.033869654,-0.064914174,0.06983336,0.00070072274,0.039066948,-0.015231567,-0.017234419,0.0060103964,0.0036414026,0.023626737,-0.013483725,0.016173955,-0.0064917207,0.057844076,0.078383945,-0.04556937,-0.00564254,-0.067789786,0.13343427,0.009626634,-0.026166527,0.058936756,-0.015221473,0.04498019,0.08157914,-0.094735354,0.0795978,0.039931905,0.014557829,-0.016744077,-0.0067165676,0.029052956,-0.013010521,-0.032270294,-0.018789735,0.03110774,0.017260063,-0.059704557,0.029260047,-0.014335095,0.046065293,-0.03684829,0.030551765,-0.12269209,0.03607121,0.050180882,-0.037542924,-0.0011007016,-0.015115224,0.030787857,-0.03400775,-0.062331934,-0.029080601,0.040427852,0.010813306,0.010705035,0.024045415,0.0021136892,-0.0038415245,0.0021730722,-0.007532665,0.030993171,0.095065884,0.05328337,0.10405835,0.025057485,-0.04749957,0.03215392,0.029863277,0.030527614,0.042480644,-0.035410684,-0.0057378174,-0.045086205,-0.00513572,-0.010665657,0.05702523,0.069987416,0.0255946,0.020889632,-0.08405269,-0.02911087,-0.020713145,-0.03259387,0.053872548,0.036968745,0.029345768,-0.008595131,-0.01024575,-0.11469341,0.0380626,0.06700694,-3.455754e-08,0.03503662,-0.08785677,0.0049828812,-0.0804122,-0.08466524,0.016694628,-0.0003802948,0.022694942,0.07285085,-0.0030934953,-0.0027474903,0.11837367,0.012537509,0.089470334,0.0029983958,-0.039838225,0.07487962,0.113661416,-0.0748064,0.032372344,-0.020438602,-0.012522233,-0.12898706,-0.010821512,0.010261197,-0.026279146,-0.040663715,0.010445133,0.122516654,-0.07337118,-0.07692253,-0.025041142,0.01067503,-0.07370981,-0.14406034,0.07198701,0.00069391605,-0.08649041,0.0015188823,-0.024786854,0.008003985,-0.01559302,-0.026338987,-0.06008555,-0.07592641,-0.037013587,-0.006195638,0.035534885,-0.002629522,0.027280949,0.04763294,-0.06792094,0.070669554,-0.07320905,-0.09623256,-0.022681683,0.06653426,-0.0085222125,0.03925266,-0.09530394,-0.037457976,-0.0065047867,0.1452479,-0.019907223 +1.14.13.229,"The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, is a Rieske nonheme mononuclear iron oxygenase. It can also act, with lower efficiency, on propan-2-ol, converting it to propane-1,2-diol. Depending on the substrate, the enzyme also catalyses EC 1.14.19.48, tert-amyl alcohol desaturase.",384,0.99999994,-0.061004944,-0.037420217,-0.092519365,0.041540775,0.0981017,-0.020147044,-0.0326879,0.068053216,0.0829203,-0.052870233,-0.023433043,-0.028258838,-0.0725023,0.04291982,-0.037956018,0.020086467,-0.03244676,-0.03686173,0.045811154,-0.024237268,0.030272821,0.02661574,0.015020725,0.029605556,0.031099804,0.007003533,0.037587818,-0.0014115197,-0.050065085,-0.049897425,0.052332614,-0.066338874,-0.008608329,-0.009613052,0.0072062146,0.04366223,-0.059113767,-0.033374194,0.011117245,0.01951744,0.047269773,-0.041977663,-0.07017502,-0.0017013431,-0.02563989,-0.032271042,-0.037610933,0.08702476,0.049138702,-0.016959524,-0.039261576,-0.05040436,-0.06326388,0.04004023,0.0160104,-0.027471764,0.04241701,-0.0012665907,-0.021133078,-0.027128456,0.060488865,0.06922899,-0.04211933,0.023235649,-0.039753325,0.013573215,-0.0012928819,-0.039560307,0.0011150283,-0.05902625,-0.05595069,-0.076350965,0.0003128221,0.012009958,0.012016819,-0.023958273,0.013598955,-0.033871993,0.06381895,-0.007921591,-0.009674532,-0.017392224,0.04184866,0.04559275,0.05417498,-0.0066098967,0.01390952,-0.05148863,0.091898,0.021315401,-0.026674008,0.044101268,-0.013769861,-0.022412326,-0.0060468176,0.04996796,-0.0015380011,0.057917707,0.041945983,0.010876066,-0.04020058,0.1262226,-0.06890045,-0.14307964,-0.106572896,0.030108454,0.0071414113,0.055520985,0.10437265,-0.010119825,0.020767454,-0.058433954,0.08894437,-0.00052550074,-0.031288933,0.05492746,0.017200435,-0.035726845,-0.05859873,-0.018575868,0.033920925,0.010113205,0.033939637,0.054571178,-0.0345137,0.0482428,-0.13478445,1.2770119e-33,0.03689674,0.012014954,-0.020265419,-0.030656068,-0.003244306,0.003325727,-0.09721752,0.019957017,-0.10124407,-0.0028827952,-0.047230873,-0.07990767,-0.021201778,0.03434535,0.026570346,-0.0731415,0.082924634,0.020212114,0.026937352,-3.776612e-05,-0.020915998,0.10467148,-0.02822865,0.006886114,0.054526806,0.031099705,-0.008889053,0.058352917,0.045860685,0.010473732,0.025152074,-0.11431803,-0.13205363,0.00026025,0.062649,-0.023401331,-0.074090384,0.016706802,-0.028594717,0.023046874,-0.0044935765,0.07397271,0.036247328,-0.029021844,0.03463808,-0.036103792,-0.036914703,0.15087882,0.016650863,0.059947025,-0.01110807,0.026772635,0.03721873,-0.03452215,-0.098585516,0.03791482,0.035913,0.05395688,0.08410916,0.0063332063,-0.008886881,0.08731943,-0.030442534,0.013099198,-0.028387407,-0.015169583,-0.04731152,0.027732484,0.036090422,0.067165345,-0.0521974,0.08210052,0.06425295,-0.07240096,0.049024105,-0.05992673,-0.038276218,-0.049926057,0.061501253,-0.05353864,-0.06478196,-0.028636333,0.03748329,-0.02800087,-0.060072456,-0.016525531,-0.060941886,0.056238748,-0.05144757,0.051026847,0.065739214,0.0010014086,-0.06932351,-0.038369097,0.036199145,-9.177813e-34,0.05126018,-0.11386649,0.0025198688,-0.08058791,-0.034154076,0.02587464,-0.010549406,0.01505982,0.0037478309,-0.02017525,0.14510842,-0.022649055,0.054967094,-0.061203286,-0.0012321459,0.057514083,0.004771602,0.10499524,0.012482538,-0.025747476,0.036831904,0.09547057,-0.007595315,-0.0078348415,-0.024006534,0.002037731,-0.018328661,0.0459731,0.021952871,0.062131766,0.009194472,0.041424874,0.013933639,-0.08944278,-0.09093674,0.03812029,-0.004676117,-0.032304548,0.0033534807,0.015085318,0.00961218,-0.0009598308,-0.03405579,0.07711524,0.032270014,0.08133956,-0.06340543,-0.02335998,0.02527103,0.0018531247,0.08381914,-0.014471724,0.026256409,0.01184054,0.023517739,-0.002291439,-0.012295138,-0.011960254,-0.05307418,-0.03957221,0.010439454,-0.048045386,0.063298814,0.03406318,0.054901138,0.0011301744,-0.07589342,0.0693214,0.08054874,-0.040415052,0.12508337,0.05736238,-0.062088773,0.03414651,-0.03181216,-0.081969395,0.016901027,-0.005366781,-0.0013528175,0.02589666,-0.012879708,-0.01152497,-0.009213688,-0.08101247,-0.00353515,-0.0843347,0.035717495,0.07380299,-0.034478836,0.1087944,-0.04719987,0.0142313605,-0.027432218,0.064657845,0.07812325,-3.9250757e-08,-0.04739476,-0.10256525,0.02438643,-0.0135193495,-0.00063119334,0.005191198,0.06260611,-0.023117008,-0.022315022,-0.011576141,0.0071760765,0.08239215,-0.0018391076,0.0057103327,0.068797134,0.021639388,0.05377014,0.032539032,-0.028666552,-0.038343146,0.050088745,0.047624107,-0.09026423,-0.0054048123,0.014156228,-0.07368751,-0.046768766,0.0047476296,-0.022377672,-0.0471511,-0.078446016,0.06879968,-0.045665164,-0.07818799,-0.092839584,0.025190625,-0.05760081,-0.006590036,-0.027203817,0.03620299,-0.014267945,0.0040904195,-0.07509264,0.008672294,-0.027209286,-0.027029159,0.07320563,0.0030397482,-0.010783939,-0.034422457,0.08003503,-0.014677383,0.051094558,-0.036802933,-0.077933915,0.05580089,-0.013762539,-0.014126974,-0.042758986,-0.08941803,0.083502315,-0.010871666,0.19719908,-0.061325118 +1.14.13.230,"The enzyme, characterized from the bacterium Thauera butanivorans, is similar to EC 1.14.13.25, methane monooxygenase (soluble), but has a very low activity with methane. It comprises three components - a carboxylate-bridged non-heme di-iron center-containing hydroxylase (made of three different subunits), a flavo-iron sulfur-containing NADH-oxidoreductase, and a small regulatory component protein. The enzyme can also act on other C3-C6 linear and branched aliphatic alkanes with lower activity.",384,0.99999994,-0.012433909,-0.03411649,-0.10101548,0.027904036,0.075485334,0.026123159,-0.100639515,0.035055507,0.058401402,-0.0730564,-0.0018126265,-0.10710607,-0.073334806,0.03389999,-0.008982873,-0.002886556,-0.0561643,-0.07215102,-0.03524024,-0.034712214,-0.0021390084,0.018201854,0.020103032,-0.0015523343,-0.008817058,-0.0116133215,0.05854599,-0.045657586,-0.069472075,-0.075485356,0.026969707,-0.04912074,0.09650446,0.003654282,0.026693013,0.09334194,0.006271248,-0.08609779,0.024023443,0.04034404,-0.035843767,0.014249781,0.0010916579,-0.060492706,-0.01794114,-0.066796735,-0.0053866147,0.005916916,0.011361284,-0.043648027,-0.022182383,-0.028235264,-0.053856526,0.04258722,0.06853164,0.02204825,-0.06346831,-0.03180676,-0.032869186,-0.018688953,0.07597305,0.00041364325,0.0603874,0.022135966,-0.0288056,-0.07118966,0.07482112,-0.08242017,0.005359479,-0.07100731,-0.13645698,-0.087015994,-0.015419448,0.007931666,-0.05732878,-0.0015363449,0.042357888,0.0067618634,0.11916869,-0.0038314532,-0.0023823162,0.015440385,-0.010863525,0.076663144,-0.014399262,-0.043122828,0.018323885,-0.037199065,0.023180006,0.011224137,0.018636614,0.016922265,0.029763682,-0.026196567,-0.02519662,0.009630359,0.14650916,0.053342793,0.00055397494,-0.03821262,-0.0028018393,0.05982572,-0.009838511,-0.0942291,-0.058015246,0.015482926,-0.025661526,0.09799013,0.031017384,-0.02015815,0.0029269198,-0.017735653,0.03951283,-0.004302607,0.034679513,0.03891138,0.038072698,-0.08119266,-0.05623081,0.1159642,0.0078927325,-0.02136794,0.12818544,0.07307767,-0.0073594335,0.0013444645,-0.110878356,1.2900003e-33,0.09030431,-0.007589441,-0.04271115,-0.053415798,0.043154977,0.0057219025,-0.030411448,0.07710651,-0.0932342,0.028859803,-0.0046682823,-0.013016275,0.05620217,0.013957412,-0.025423365,-0.02891324,-0.05127044,-0.05825613,-0.009510587,0.023394173,-0.011469778,0.046873253,0.0076799295,0.004299951,0.040022124,0.034835402,-0.0047652144,-0.013317274,-0.008032823,-0.018568479,0.0017785842,-0.10968648,-0.15559068,0.02097617,0.073416084,-0.008835987,-0.018655302,-0.02036318,-0.097182736,0.035311215,-0.007178607,0.0449574,-0.00966003,-0.13812546,0.037411798,-0.02138962,-0.015843054,0.14276178,0.055411234,0.06795575,0.009747063,0.013318513,0.08222947,-0.06034825,-0.03387065,0.06221511,-0.008391747,0.038110457,0.061843675,0.0068857865,-0.0081030335,0.0020157073,-0.05106035,0.051941592,-0.018053904,0.039176926,-0.09371112,-0.021387424,0.05518813,0.08863083,-0.026015552,0.02993026,0.06883545,-0.020685213,0.04360028,-0.058126535,-0.08030567,-0.0024792051,0.042175833,0.09453698,-0.024001323,-0.020216707,0.03631925,-0.053454317,-0.06448641,0.004220586,-0.049410395,-0.01450764,-0.016564362,0.075327225,-0.029223276,-0.08646836,-0.058577895,-0.017738901,0.09711923,-2.6172154e-33,0.07275176,-0.07263327,0.0018540929,-0.089552596,0.016157784,0.091612756,0.028033577,0.015764825,-0.026845561,-0.024075491,0.12916467,0.0091668805,0.009588607,-0.062101886,0.067494884,0.08299264,-0.007219414,0.07368166,0.026171288,0.026276326,0.024798913,-0.022026343,-0.08663384,0.015138343,0.049751457,0.01640341,-0.032633767,-0.0068606855,0.044600956,-0.007361692,-0.0168281,0.025335839,-0.02457509,-0.06370486,-0.052552897,0.013029253,-0.109944165,-0.024035152,0.010589351,-0.010324207,0.014668938,-0.011360324,0.009731743,0.10182131,0.02068491,0.08514044,-0.067957535,-0.04433501,0.02951957,0.01264534,0.0033091714,-0.084756896,-0.016504996,0.05920143,0.044114616,0.049238596,0.026600828,0.017592765,0.05243469,-0.0069065397,0.030316979,-0.057308797,0.02404608,0.022137048,0.026753677,-0.019723587,-0.1114576,-0.020728657,0.062463384,-0.0064526293,0.10848008,-0.060609877,0.044976655,-0.016728252,-0.006486897,-0.05152536,-0.0064772,0.00565082,-0.0009884444,-0.006727631,0.06711729,-0.02617338,0.022693621,-0.049352556,0.029737785,-0.043341346,0.03270616,0.010604822,-0.046521664,0.08983631,-0.041364156,0.015239938,-0.06926973,0.03992624,0.04476968,-4.2987462e-08,-0.020823015,-0.12536591,0.015450814,-0.028615724,0.03531759,0.10588078,0.01936866,0.0061193146,-0.024646003,0.007813789,0.07316161,0.0550007,-0.006465895,-0.0076360465,0.039189328,-0.028723778,-0.03405438,0.028155258,0.021189354,0.018847695,-0.03875017,-0.013769242,-0.0601953,-0.007530226,0.014871517,-0.018323906,-0.006295345,0.058090225,0.018910531,-0.034648128,-0.08110149,0.057303943,0.050252568,-0.016064247,-0.08826333,-0.010344071,-0.026503807,-0.018162759,-0.10888559,0.043523557,0.030162126,0.008396513,-0.06796067,-0.026775153,0.052053206,0.009750416,-0.033625226,0.018251231,0.0005735633,0.007147926,0.06621516,-0.043592736,-0.0057473574,0.02700864,-0.051197592,0.063554876,0.045561105,-0.07518149,-0.018873084,-0.0072876136,0.021437114,0.015353843,0.14606857,-0.039880052 +1.14.13.231,A flavoprotein (FAD). This bacterial enzyme confers resistance to all clinically relevant tetracyclines when expressed under aerobic conditions. The hydroxylated products are very unstable and lead to intramolecular cyclization and non-enzymic breakdown to undefined products.,384,1.0,-0.08817017,-0.052568153,-0.11414424,0.026930992,0.1034384,-0.024401592,-0.023413712,0.10544985,0.052156977,-0.0684329,-0.01407748,0.002921523,-0.0034468684,0.028346576,-0.0727433,-0.01597117,-0.030314052,-0.0021450494,-0.06254441,-0.029001983,-0.011722824,0.032012586,0.038248293,0.01699799,-0.017964354,-0.025556954,-0.02084907,-0.034947727,-0.04402202,0.02894754,0.087371856,0.112392165,0.017513426,-0.004106325,-0.012602844,0.0642596,0.035948988,0.0144382715,-0.011101977,-0.01845325,-0.0070692264,-0.034215536,0.042206824,-0.012572933,0.11091769,0.022241572,0.009695592,0.040577047,0.009910828,0.0442648,-0.030459488,-0.04490716,-0.07223737,0.059737097,-0.013534681,0.018789744,-0.02681448,-0.059533313,-0.0012821943,0.0129760355,0.016607748,-0.016140265,0.04845274,0.04938468,0.028961303,-0.07630712,-0.04701924,-0.01790845,0.0452947,-0.0016284793,-0.013381949,-0.025162268,-0.032230653,0.06279446,0.0035015945,0.055720422,-0.012825656,-0.04888775,0.014716727,-0.005254701,0.064033054,-0.0758983,0.08578986,0.101212315,0.080143444,-0.088147335,0.01834851,-0.0068752854,-0.03387301,0.086983226,0.0013316477,0.05440149,0.044840187,0.009724865,-0.0727294,0.019508308,0.018754398,-0.07534899,-0.055193692,-0.03699473,-0.08200276,0.0008141632,0.06481988,0.032773007,-0.040059496,-0.10039911,0.022667475,0.039468545,0.0056882463,-0.024665954,0.016680343,0.002756531,0.035821896,-0.09460376,-0.0028366123,0.0477698,-0.024133444,-0.06515403,0.0038386048,0.013041286,-0.05455224,0.07257684,0.04411098,0.052821327,0.05298662,0.031579815,-0.036665652,3.8803304e-33,0.056570962,-0.0079549365,-0.03587836,-0.006708553,0.0056817373,-0.028523235,-0.04684263,-0.061988562,0.06222978,-0.013240311,-0.04953912,-0.0056559006,0.046835072,8.1151506e-05,0.06869956,0.016669482,-0.04542366,-0.055299122,0.08517276,-0.08248506,0.016156537,0.022453314,-0.0050458843,0.031624444,0.015508328,0.0011780554,-0.08081482,0.028734457,0.014111476,0.044061042,-0.023418725,-0.08233658,-0.060142413,-0.030417494,0.013800997,0.06302989,-0.1143495,-0.052156933,-0.061610647,0.09895567,0.004492805,-0.048544876,-0.005217849,-0.016577272,0.046599563,-0.023116603,-0.08778548,0.09617803,-0.037867658,0.078611486,0.06565841,-0.04124789,0.06635438,0.050718635,-0.081756696,0.010883125,-0.025909852,-0.011103681,0.009225848,0.0036829622,-0.007031627,0.07140665,-0.067511864,0.11604716,-0.13141522,-0.037670836,-0.0010034234,-0.073192686,-0.02459538,0.11898567,0.0031568191,-0.03883728,0.08736731,0.0009985812,0.10386204,-0.037972357,-0.013369615,-0.057317212,0.030275743,0.0038859707,-0.010526433,-0.043930296,-0.027966877,-0.013308608,-0.044852573,0.020771075,-0.035685156,-0.035333544,0.031072987,0.0013617249,0.053733863,-0.0880858,0.0038570666,0.04325355,0.021946842,-3.5843163e-33,0.026226139,-0.09340705,0.073432945,0.0011888362,0.024291411,0.041779004,-0.00081594056,-0.051929243,0.03574151,-0.073572874,0.040145006,-0.1059297,-0.0577258,0.031928208,0.022210307,0.00093942886,-0.055265553,0.025227414,0.046519052,0.008231308,-0.031171627,-0.0319041,0.037031017,0.052290358,0.014876301,0.032277763,-0.019703614,-0.017130163,0.04545259,0.032989725,-0.04840973,0.03479257,-0.09154528,-0.0009236401,-0.04182373,0.085859045,-0.051677607,-0.0037046552,0.009990756,0.0135521125,0.038536265,0.037191436,-0.021996055,0.03466106,0.053152394,0.061424065,-0.008137158,0.0070881722,0.07131383,-0.05391648,0.070086405,0.032965075,0.0047897887,0.07143125,0.07577137,0.040407345,0.067957625,0.04201398,-0.056631405,-0.043409742,-0.0050777444,-0.13782741,0.030104052,0.0015407844,0.07891549,0.07417185,0.04568713,0.17040808,0.014093381,0.017658247,0.08716944,0.0139190145,0.013115204,0.025662206,0.014353345,-0.041697204,-0.056730438,0.029189058,0.017356398,-0.0037381088,0.029597357,0.023056753,0.004614706,0.018623533,-0.07733423,-0.12454711,-0.017366704,0.033943508,0.021342473,0.01598191,-0.010473174,0.054590274,-0.007034109,-0.02572961,0.10947913,-3.652851e-08,0.026929926,-0.082269125,-0.018659994,0.006311241,0.116396636,0.03637945,-0.064291045,-0.045111384,0.009971731,-0.023362434,-0.04670992,0.11278731,-0.0030178314,-0.0028352358,0.0035974048,-0.0036986396,-0.032005753,-0.019624798,-0.0019797715,-0.03560523,-0.112347886,0.046889953,-0.07032303,-0.005976745,-0.07253149,-0.032012254,0.0033554458,-0.013676887,0.060457833,-0.050094888,-0.013044719,0.03611678,-0.02538288,-0.03955396,-0.13523665,-0.005441613,0.04344759,-0.0811125,-0.04226145,0.039521668,-0.110272944,0.015997928,-0.055139415,-0.028532943,0.0073903995,-0.042903885,0.038723025,7.061552e-05,-0.0815213,-0.07982001,0.004059928,-0.027873999,0.029368516,0.037492238,-0.04584665,0.01101194,-0.041636057,-0.04875483,-0.019435406,-0.08472972,-0.024973523,0.026255907,0.13571768,-0.018886015 +1.14.13.232,"The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. That bacterium possesses two enzymes that can catalyse the reaction - OxyE is the main isozyme, while OxyL has a lower activity. OxyL is bifunctional, and its main function is EC 1.14.13.233, 4-hydroxy-6-methylpretetramide 12a-monooxygenase. Contains FAD.",384,1.0,-0.056092013,-0.0057233307,-0.16022463,-0.043060437,0.05234945,0.007753241,-0.06271968,0.05558757,0.08244754,-0.06316996,0.0020468088,-0.060175937,-0.02900883,0.05063958,-0.047961153,-0.0046473113,-0.08226381,-0.027906254,0.014803782,-0.08735112,0.04765696,0.07569371,0.039662644,-0.012611823,0.0045604687,-0.0075233825,0.00503146,0.070192195,-0.048657283,-0.05272839,0.07543365,0.012394861,0.07028902,-0.077439345,0.007279194,0.066815026,0.0056604566,-0.060629763,0.1201719,0.0015757876,-0.06821195,0.020791342,-0.016522786,-0.023681263,-0.025297495,0.0063783526,0.092774585,0.04004004,0.02002906,-0.020427171,-0.0025382012,-0.070339896,-0.09463099,0.08242675,0.037591603,0.054071005,0.0079212,-0.029099973,-0.017310275,-0.055404224,0.053968858,-0.0013186142,0.03674066,0.08765907,-0.03707838,-0.04622712,0.015714673,-0.12477718,-0.009290954,-0.053856283,-0.08570614,-0.080549166,0.0013045507,0.029568762,-0.03902859,0.0039296765,0.022556439,-0.07194043,-0.008964338,0.0033389311,-0.0071456227,-0.050172616,-0.013859457,0.07944554,0.08169149,-0.08199542,-0.010373454,-0.014392285,0.025977388,0.038352184,0.061237197,0.00897533,0.010242544,-0.030176016,-0.038721178,0.0022525624,0.02651123,0.004444928,-0.013919193,0.0058808923,-0.07026143,0.04454105,0.0037104215,-0.06388371,-0.0032471947,0.048849065,-0.0024660411,0.04971893,0.020232908,-0.028904462,-0.039297655,-0.022252982,0.038723435,0.016953912,-0.01174095,0.03956542,0.028129837,-0.05957889,-0.03189084,0.011837296,0.009911698,0.031937487,0.037030198,0.057997994,0.029132186,0.0368455,-0.10142509,1.8375127e-33,0.024209144,0.043777276,-0.022792337,-0.092550226,0.052914683,0.011426005,-0.01645339,0.0160018,0.00691083,0.0139229745,-0.09195424,-0.037777662,0.07169469,0.035335198,0.031112239,-0.017951068,-0.004674442,0.034661286,0.013427949,0.049934067,-0.008042759,0.03661774,-0.025376214,0.0062437295,0.055485625,0.0407645,-0.010311531,0.040659055,0.031117987,0.0100261,0.0016880411,-0.065863036,-0.09777454,-0.0017355422,0.030905208,-0.023169719,-0.09190315,-0.0075818747,0.029014567,0.0143954195,0.03027089,0.011627768,-0.035874486,0.0027073284,0.0650412,-0.040950056,-0.05355045,0.12728606,0.097521886,0.08867825,0.014127176,-0.06497153,0.078293376,-0.043762412,-0.050932344,0.051677246,-0.06766389,0.05474567,0.07533289,0.02733642,-0.041523766,0.03745588,-0.014124674,0.037024632,0.010492195,0.027306544,-0.022735456,-0.06671708,-0.04891266,0.053991906,-0.05707093,0.06090428,0.06428324,-0.0003848529,0.033506334,-0.0099387895,-0.029890213,-0.07630548,0.12643449,-0.009378101,-0.024389388,-0.003152321,0.03092095,-0.08445239,-0.026439987,0.0034896634,-0.05338917,-0.0017072608,-0.014021189,0.12590836,0.023340806,-0.069662854,-0.13182783,0.011295824,0.03927675,-3.5333843e-33,0.057225518,-0.04247574,-0.009219264,-0.11931581,-0.034950923,0.08910371,-0.03226969,-0.06101837,0.007216236,-0.03600713,0.050928373,-0.023071118,-0.0059326557,-0.08896621,0.0056646303,-0.032081444,0.005677486,0.074686795,0.0048073675,0.0076503325,0.04276579,0.063147336,-0.028595591,-0.032997254,0.0066143204,0.007870809,-0.06462163,0.05530126,0.074069835,0.07971766,0.0012536169,-0.012607701,-0.050048526,-0.010022437,-0.029238598,0.121297866,-0.10540715,-0.0032453877,0.09395209,0.048317842,0.104543954,0.011501871,0.011005706,0.05630372,0.032295,0.059979733,-0.096289665,0.008012338,-0.0060635116,-0.07377778,0.0037466213,0.04539756,0.025034541,0.005211243,0.07618528,0.047721807,-0.0009537255,-0.03525834,-0.04705263,-0.0896092,-0.02255841,-0.045327976,0.03231356,0.0235856,0.020191234,0.009574134,-0.06855348,0.043880798,0.064494155,0.047090523,0.060813457,-0.008479666,-0.041534435,-0.033002336,-0.04291436,-0.03610113,-0.079161495,-0.04873354,0.010452793,-0.007448996,0.015551681,0.03940975,0.04435229,-0.077785686,-0.07357707,-0.034737967,-0.029253602,0.053834334,0.06700082,0.01418619,0.006669823,0.00072669727,-0.050018262,-0.0017876949,0.1127036,-3.951434e-08,0.021790171,-0.061893795,0.11431579,-0.013089083,0.036722112,0.019471617,0.0046891533,-0.0018718368,0.02664415,-0.03256054,0.015458465,0.06989008,0.026173202,-0.043157585,-0.019389993,0.0143308835,-0.05817081,-0.016405283,-0.00342501,-0.035894256,-0.06206062,0.00047090393,-0.07499361,0.019079989,0.03122992,-0.013700877,-0.001269797,-0.010099047,-0.06552442,0.008187457,0.009101674,0.020048803,-0.05888284,-0.012722739,-0.08435654,-0.052318398,-0.0115387915,-0.021319203,-0.035246298,-0.014076945,0.0010414821,-0.045066945,-0.13065706,0.023292996,0.025079137,0.041839212,0.030544538,-0.051902927,-0.044809602,-0.068557076,0.09642341,-0.015850194,0.011848863,0.024148239,-0.08480841,0.06671526,-0.028207727,-0.052581966,-0.062719926,-0.0123692835,0.0061031766,0.027619993,0.2144524,-0.06494657 +1.14.13.233,"Contains FAD. The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. The enzyme is bifunctional, and can also catalyse EC 1.14.13.232, 6-methylpretetramide 4-monooxygenase.",384,1.0,-0.03563633,0.005390095,-0.15283273,-0.061741672,0.0653881,0.038472366,-0.0631028,0.0714799,0.083150655,-0.038419683,-0.019668082,-0.09555594,-0.015231952,0.043476872,-0.06275932,-0.041229475,-0.08424561,-0.037628997,0.024917474,-0.07182678,0.020137168,0.08554152,0.03697946,-0.0104543995,0.0050347294,0.04236399,0.019753039,-0.02579315,-0.030113116,-0.01330336,0.09520103,0.024616163,0.060131565,-0.062561035,0.038305014,0.077942036,-0.009140855,-0.03721141,0.11211399,0.010224253,-0.046906553,0.007530606,0.024315465,-0.03255277,0.011158824,0.0363042,0.07367599,0.049048506,0.011783317,-0.022010582,0.022307068,-0.047384106,-0.06621979,0.07643595,0.04480951,0.05995262,0.004438621,-0.05214269,0.0053619216,-0.027649123,0.063186996,-0.0035027158,0.04301029,0.053688727,-0.039197814,-0.008963899,-0.022973064,-0.105466485,0.011948483,-0.04211074,-0.05617191,-0.06664011,0.00015791807,0.03307531,0.008405045,0.030244237,0.014373688,-0.08156671,-0.009824682,-0.005900474,0.0064367456,-0.04452864,0.02192357,0.07724795,0.072275065,-0.07168971,0.06407541,-0.019253397,0.019324008,0.04483506,0.06439344,-0.02740189,0.0097963065,-0.070722096,-0.05657066,0.028261738,0.0037863217,0.0034337419,0.02718464,-0.030375369,-0.06598122,0.04485327,-0.013466459,-0.019515982,-0.07035243,0.004005981,-0.0015884497,0.10773386,0.0045333244,-0.05223605,-0.028087797,-0.016048701,0.036667246,-0.018190695,-0.018983029,0.01168865,0.037878554,-0.13101877,-0.027102927,0.036829513,0.009938397,0.01673019,0.04151536,0.09587887,0.051809993,0.036669042,-0.12959144,2.6995534e-33,0.01999497,0.017287413,0.006747595,-0.09985335,0.04542085,-0.0014538924,-0.05706034,0.015512243,-0.0042379173,-0.03035604,-0.08594386,-0.055296272,0.04686598,0.038024005,0.024064885,-0.004001722,-0.031555187,0.02346266,0.03992585,-0.043834485,-0.0061571314,0.040803023,-0.027837932,0.025037967,0.056772392,0.045364648,-0.014375661,0.064538874,0.07929451,0.004819232,-0.035348684,-0.074524306,-0.10184891,0.0070424043,0.025112337,0.03661126,-0.09982842,-0.024727091,-0.007838533,0.07328875,0.030911477,0.0052396636,0.00699389,0.0027723133,0.0538931,-0.073474415,-0.051964853,0.11366817,0.07316615,0.08385109,0.049681846,-0.022552172,0.05931262,-0.019531809,-0.05602109,0.05009996,-0.06741954,0.040989846,0.051664755,0.032266095,-0.030255135,0.044492517,-0.05170975,0.06007801,-0.0019630685,0.021591077,-0.002654374,-0.06379628,-0.03240643,0.065685585,-0.057017185,0.034493294,0.09931531,0.013523562,0.054960024,-0.0077943993,-0.025578504,-0.07119156,0.09371024,0.0019126188,-0.03975007,-0.03444734,0.0058671297,-0.08138338,-0.025939079,0.0013055282,-0.07309091,-0.084346436,0.007678806,0.071277976,-0.016047284,-0.10874453,-0.12667382,0.050267898,-0.0018326462,-4.08585e-33,0.048859607,-0.07690818,0.06010704,-0.09836109,-0.020127364,0.10460239,-0.00756163,-0.031673975,0.030151596,-0.05876393,0.08054305,-0.04760254,0.002206272,-0.05426935,-0.009144471,-0.022580892,-0.005815071,0.064666376,0.03324591,0.033324372,0.038875464,0.017612692,-0.0077598444,0.009497946,0.039029654,0.030418545,-0.03889068,0.032991886,0.07630192,0.06236212,-0.014151971,-0.010009827,-0.04356413,0.0033979851,-0.069573,0.09565052,-0.05738808,-0.008777829,0.06511573,0.014363183,0.067012385,0.0055933963,0.013798634,0.09355594,0.04857552,0.05141729,-0.08573293,0.05412473,0.040262565,-0.08653622,0.0064566545,0.02596486,0.04576498,0.017995592,0.06662726,0.023133274,0.018303217,-0.0016949404,-0.03452419,-0.059155058,-0.0027054283,-0.067415856,0.035179466,-0.00022634107,0.079961814,-0.044277664,-0.067969866,0.055645905,0.031297516,0.039994583,0.092676945,-0.019039389,-0.059029512,0.0019269077,-0.024678662,-0.025790147,-0.066868156,-0.02153853,0.043541223,0.017751802,0.05170733,0.04674396,0.01328816,-0.039082896,-0.075243205,-0.03832031,0.0064490438,0.050390698,0.028115144,0.027365735,-0.054756835,0.048326757,-0.016096286,-0.0040074303,0.11381653,-3.764716e-08,0.05063474,-0.052122824,0.050412446,-0.041206922,0.06680626,0.030202704,-0.02614892,-0.047023688,-0.033323377,-0.054489143,-0.023971546,0.051821623,-0.029113928,-0.056506403,0.002188481,0.011756268,-0.0771571,-0.03806374,0.0029914612,-0.022676976,-0.077816255,0.03363309,-0.08144262,-0.0060249697,-0.01792499,-0.02377643,0.026413117,0.0008943782,-0.062112488,0.0090088155,-0.0038431177,-0.00081464584,-0.048513677,-0.029606735,-0.09310903,-0.018353324,-0.030381303,-0.05636219,-0.04722621,0.009583695,0.0075903265,0.0109744165,-0.096746385,-0.022213977,-0.03871658,0.040412623,0.0143482415,-0.008542376,-0.1018229,-0.05674572,0.06739928,-0.037407022,-0.0018249076,0.019625964,-0.08865533,0.040704906,-0.03287039,-0.090008855,-0.040008597,-0.035249062,0.02101705,0.033585027,0.20307252,-0.021202799 +1.14.13.234,"The enzyme, characterized from the bacterium Streptomyces rimosus, is bifunctional, catalysing two successive monooxygenation reactions. It starts by catalysing the stereospecific hydroxylation of anhydrotetracycline at C-6 (EC 1.14.13.38). If the released product is captured by EC 1.3.98.4, 5a,11a-dehydrotetracycline dehydrogenase (OxyR), it is reduced to tetracycline. However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C-5, producing 5a,11a-dehydrooxytetracycline, which, following the action of OxyR, becomes oxytetracycline.",384,1.0,-0.08466837,-0.026160602,-0.11534521,-0.024375806,0.06268538,0.0036399565,-0.05031388,0.06775699,0.069917224,-0.047328763,-0.0052405754,-0.042701416,-0.017124765,-0.0012347783,-0.10572584,0.031904425,-0.07498602,0.0022849569,0.018534897,-0.08821441,0.02403802,0.009870873,0.0016017619,-0.011028064,0.008007415,0.021118911,-0.04584371,0.032731097,-0.103491545,-0.06499352,0.046117235,0.040817555,-0.0046470985,-0.04455252,0.045995276,0.11649083,-0.071506776,-0.034638952,0.09644309,-0.010515494,-0.032633435,-0.0062543033,-0.052025307,0.0234156,-0.06000386,0.0022098005,0.05603487,0.046784695,0.030248929,-0.012541355,0.0026373935,-0.0043535056,-0.09907309,0.03798678,-0.008102161,0.02156272,0.01641361,0.006609316,0.04624486,-0.047678437,0.043313313,-0.019183643,-0.0001346713,0.06748827,-0.013715522,-0.069624536,0.045195956,-0.12372946,-0.0041295667,-0.05855806,-0.058431268,-0.050616365,0.026158998,0.0052005616,-0.023694944,0.047094822,0.001466124,-0.080116265,-0.019622006,0.0257322,-0.029863687,-0.021072503,-0.012728064,0.03333125,0.031232746,-0.0877972,-0.028258087,-0.014348283,0.050140813,0.03762921,-0.0064624394,0.022739364,-0.000867485,-0.024933593,-0.016009634,0.027091319,0.081522204,0.02664873,0.01124482,0.0132197905,-0.055687554,0.04949644,-0.02735513,-0.030712003,-0.024986358,0.018734017,-0.0071262736,0.05841715,0.03424473,-0.0093502095,-0.05341905,-0.018480796,0.022637617,0.017192906,-0.021362852,0.119289614,0.03276652,-0.021791257,-0.047028605,0.019498527,0.041730758,-0.013178178,0.028082058,0.028537335,-0.042988576,0.053951163,-0.07646886,4.5815734e-33,0.026599243,0.026068117,0.025446206,-0.006686904,0.03060449,0.01115142,-0.065570004,0.041569382,0.025519243,-0.007169903,-0.08761404,-0.023144448,0.08726182,0.020863917,-0.041265823,-0.049581397,-0.016078359,0.028292717,0.0051435223,0.045009952,-0.031621948,0.032066755,-0.03076431,0.035327792,0.012058715,0.04305194,-0.0378148,0.013424464,0.0748548,0.024215115,-0.042361956,-0.063951634,-0.06914035,-0.034241322,0.10358093,0.0033195168,-0.061997462,0.0025192036,0.050849568,0.019364681,-0.0029682694,0.007493875,-0.045676984,-0.03945008,0.052921247,-0.054441135,-0.06068936,0.11757633,0.00697181,0.07840642,0.025035344,-0.041443188,0.069705494,-0.045302298,-0.041208927,0.02810362,-0.051378243,0.02538286,0.0700811,0.08459127,0.019224145,0.08088464,-0.024957284,-0.0076869857,-0.018691206,0.004715899,-0.04766679,-0.047497187,-0.015744396,0.016945366,-0.058084786,0.07922293,0.072186455,0.041987453,0.06644009,0.023531169,-0.004255501,-0.01272369,0.12381382,-0.04734338,-0.019973747,0.047270425,0.04690102,-0.06253553,-0.031491894,0.043028727,-0.082107656,-0.06326278,-0.03418909,0.09560084,0.0360905,-0.08292818,-0.08642018,-0.051820934,0.003596188,-5.824409e-33,0.05457945,-0.071607575,-0.050183784,-0.112920225,-0.018519748,0.073899165,0.03291948,-0.070287086,-0.00663538,-0.04490307,0.059024267,0.011093103,-0.025925146,-0.04168635,-0.007248878,-0.021343483,0.046383213,0.10068302,-0.014899044,0.08402833,0.10656597,0.037408095,-0.027917746,-0.017558528,0.014564437,0.006043587,-0.06256515,0.032489344,0.112904035,0.06591738,-0.044486176,-0.012065636,-0.01109505,0.006941886,0.039812297,0.12600276,-0.119566254,-0.03290415,0.051960938,0.06680597,0.06328147,-0.01976391,-0.021022815,0.04635856,0.08194152,0.05149335,-0.107906625,0.05362929,0.04123178,-0.042832036,0.046992473,0.0066965832,-0.030039037,0.015022465,0.04594294,0.042433083,0.08663926,-0.019254398,-0.04198895,-0.06432016,-0.03121591,-0.02627635,0.024712525,-0.0067632357,0.0024950865,0.026868612,-0.021956617,0.0314928,0.04058849,0.017872024,0.035844944,-0.010705587,-0.030500444,-0.084347524,-0.04379762,-0.04876384,-0.029655721,-0.03335999,0.0029303906,-0.020169547,-0.016742554,0.06828615,0.06251676,-0.094854414,0.044698406,-0.10212195,0.01612422,0.018054975,0.018426893,0.0656169,0.0074087013,-0.0066989176,-0.06915086,0.03779376,0.10947356,-4.627277e-08,0.048834763,-0.059508245,0.113932535,0.02362108,0.08369023,0.027266704,0.0010106346,-0.07040267,0.033821624,-0.10100266,0.046027284,0.049720664,0.06428434,-0.03578865,0.011916613,0.037813548,-0.051259995,-0.033655927,-0.0033846723,-0.02178312,-0.116351694,0.010070112,-0.059643757,-0.006941755,0.0039353627,-0.06293936,0.008142712,-0.02157553,-0.009456199,-0.062161304,0.027337005,0.038491525,-0.06368743,-0.0505365,-0.051514186,-0.050002676,-0.052974343,0.023159664,-0.011059346,0.0020261204,-0.061548155,0.020971768,-0.1134925,0.042970683,0.049335673,0.047338005,-0.042908374,-0.01490518,-0.07202516,0.009775988,0.08875997,0.0022622542,0.018759048,-0.0031833283,-0.058270883,0.053876154,-0.020452121,-0.10197897,-0.08062202,-0.06069442,-0.03981418,0.059701715,0.1706642,-0.03785514 +1.14.14.33,"The enzyme is part of a two component system that also includes EC 1.5.1.42, FMN reductase (NADH), which provides reduced flavin mononucleotide for this enzyme. It acts on EDTA only when it is complexed with divalent cations such as Mg2+, Zn2+, Mn2+, Co2+, or Cu2+. While the enzyme has a substrate overlap with EC 1.14.14.10, nitrilotriacetate monooxygenase, it has a much wider substrate range, which includes nitrilotriacetate (NTA) and diethylenetriaminepentaacetate (DTPA) in addition to EDTA.",384,1.0,-0.07347144,-0.0053561353,-0.061244316,-0.011950732,0.041339945,-0.008308123,-0.046549443,0.029736528,-0.012333989,-0.03413255,-0.0030357863,-0.08527532,-0.088995226,0.046624757,-0.023437675,-0.026420971,-0.05326717,-0.095824294,-0.0060694083,-0.030605836,0.033614878,0.064364165,-0.012359055,-0.014371791,-0.012442785,0.020595053,0.041557513,-0.008664821,-0.0154926805,-0.09884923,0.025744129,-0.06441974,0.04057278,-0.041043438,-0.00034186107,0.034804113,-0.01740521,-0.010793193,-0.013499713,-0.0015258704,0.050539162,0.04533972,0.029765753,-0.04212585,0.0334556,-0.059300773,-0.01668895,0.03600632,-0.0019694064,0.055762313,0.0456848,-0.047067765,0.03144965,0.08133388,0.10726788,-0.013402779,-0.058685075,-0.031388864,-0.09728359,0.030397905,0.059564196,-0.008492911,-0.01320829,-0.01746168,0.091424674,-0.021501528,0.03533092,-0.13504513,-0.02237026,-0.08196458,-0.059454292,-0.06492664,-0.052040566,0.03048307,-0.032985244,-0.009822123,0.030421263,-0.041772548,0.08863354,0.005006934,0.055695955,0.084295444,-0.024991265,0.060082026,0.022407282,0.004331911,-0.03839701,0.027382087,0.05132487,0.023593053,0.06886199,0.027618513,-0.009066732,0.025658464,-0.04674908,0.026765805,-0.065240934,0.09411303,-0.038061216,0.013880313,0.023499928,0.094119556,-0.07883059,-0.023684608,-0.1765561,0.006751541,0.048100237,0.05495588,-0.014455767,0.0014836878,0.02915136,-0.006368815,0.038434416,0.054247078,-0.07275176,0.08379343,-0.03150397,-0.06010553,-0.015545178,0.01720073,0.0023957554,-0.036361203,0.05896526,0.12579626,0.034428515,0.05190403,-0.11754245,3.7689813e-33,0.057438623,-0.04723471,-0.052618008,-0.051878076,0.0851015,0.03484935,-0.03711541,0.029300308,-0.06409885,-0.031925727,-0.04240041,0.051118296,0.05615315,-0.006827821,-0.045632582,-0.026254361,-0.0035164487,0.02273908,0.02006106,0.00090612704,0.03377499,0.034115683,-0.04646415,-0.002317225,0.0059597553,0.04067898,-0.093809165,0.0659944,0.0325124,0.0012069443,-0.04017027,-0.14446601,-0.036247358,0.037516866,0.061116233,-0.046638567,-0.04425905,0.0027304264,-0.02168619,0.06323173,-0.0028217756,0.06545633,-0.035623282,-0.032499116,0.038623396,-0.04904,-0.08674917,0.09912601,0.03386334,0.07163637,0.085241996,-0.03483299,0.081338875,-0.0810914,-0.033807814,0.061513405,-0.05311145,-0.0024630933,0.07148314,0.03605776,-0.020069133,0.018287776,-0.007457324,0.012366138,0.046185795,0.066258185,-0.04106275,-0.09763503,0.042708743,0.047263313,-0.029329237,0.017308615,0.05256776,0.046775937,0.02541033,-0.08605636,-0.051869255,0.04536961,0.024374807,0.040092085,-0.0057461383,-0.01020773,-0.008179765,-0.04951629,-0.033119835,-0.028035916,-0.0093717445,-0.018179089,0.008687674,-0.007579869,0.097428426,-0.03410824,-0.07897894,-0.08126719,0.113290876,-4.394193e-33,0.041927908,-0.063916236,-0.035142038,-0.10157804,-0.006540509,0.06331552,0.026583547,-0.03544079,0.07857654,0.01222255,0.12177607,-0.011854307,-0.024781212,-0.024555402,0.06577749,0.007468291,-0.03531383,0.05958871,0.003990559,-0.028675243,-0.0036663741,0.060611676,-0.015129861,0.04137506,0.045495816,-0.026654158,-0.05902487,0.077513166,0.101954825,0.0015699535,-0.09052125,-0.0017246479,-0.087591924,-0.034796163,0.011144336,0.0476252,-0.035897955,-0.019586839,-0.0048924517,0.01226274,0.018259184,0.033507388,0.0064621237,0.042788748,0.0017090155,0.111422524,-0.12972198,0.066019095,-0.041928284,-0.05070484,0.034989025,0.021334471,0.036609665,0.061020985,0.03202022,0.025057856,0.07305266,0.048940223,0.008533155,-0.0049842424,0.013614471,-0.09382509,-0.029431399,-0.01339549,0.0109350495,-0.012199383,-0.012025845,0.024237473,0.03748706,0.04256204,0.04662241,-0.045898106,0.0790317,-0.011072025,-0.0747451,-0.027697904,-0.024699483,-0.007436949,0.03314962,-0.068865635,0.014322538,-0.0039616358,-0.0016611251,-0.03810481,0.00377052,-0.009311897,0.018614883,0.091295496,0.011671077,0.078157745,-0.02536299,-0.019850688,-0.09668359,0.02070548,-0.0072687455,-4.595853e-08,0.050459385,-0.14303654,-0.002628802,-0.05007601,0.021402083,0.037123244,0.076915994,0.028398551,0.054243438,-0.011492674,0.0707475,0.0677005,0.029187854,-0.008232166,0.03019689,0.0026938077,0.009462536,0.03668551,-0.03470104,0.032307893,-0.04344942,0.0016909679,-0.09979345,-0.021731174,-0.062924296,-0.03328455,0.022131028,0.068319604,-0.00292967,-0.050478425,-0.011876874,0.038507726,0.04258726,-0.04098682,-0.14573598,0.0049656606,0.0135074025,-0.013097554,-0.083379745,0.005073454,-0.03498078,-0.064268686,-0.0008946098,-0.01099406,0.044029873,0.007619493,0.02218961,0.011063601,-0.00040198906,-0.005016496,-0.05252934,-0.02757848,0.002020986,-0.07125574,-0.102071986,-0.018765641,-0.0274221,-0.05478943,-0.017834952,-0.016922507,0.031287845,0.04003744,0.15329559,-0.013070492 +1.14.14.34,"The enzyme, characterized from Pseudomonas strains, allows the organisms to utilize methanesulfonate as their sulfur source. It acts in combination with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42), which provides it with reduced FMN. cf. EC 1.14.13.111, methanesulfonate monooxygenase (NADH).",384,1.0,-0.0064283796,0.020414436,-0.11828068,0.016368244,0.052945532,0.07789552,-0.09424863,0.06880665,0.04445513,-0.050053474,0.0056852857,-0.045182224,-0.084399,0.04289761,-0.05514172,0.0361637,-0.03280578,-0.01612939,0.01769102,-0.024676342,0.036472958,0.018246073,-0.01088829,0.002081337,-0.012912357,0.0068051503,0.014586537,-0.034034785,-0.04047848,-0.040337935,-0.008527477,-0.029574815,0.056420457,-0.02572843,-0.02041891,0.0913128,0.016924368,0.008434557,0.03810912,0.035476588,-0.023662506,-0.013280145,-0.0031790044,-0.06415678,-0.070103355,-0.025780642,0.006471319,0.0584186,0.043411124,-0.0641444,-0.062327217,-0.00040553417,-0.026295409,0.075888,0.07692624,0.079547256,-0.024038829,-0.03583774,-0.066330045,-0.056300655,0.01707007,-0.036880117,0.0011501451,-0.015152981,0.02571621,-0.04127972,0.044381604,-0.05134811,0.019155523,-0.039599273,-0.10875095,-0.007466514,0.04033705,-0.008057945,-0.032653414,0.064607784,0.0003439663,-0.010280151,0.11454475,-0.021896748,0.049298093,0.03674293,0.040434156,0.046314973,0.038315173,-0.042861152,0.0444911,-0.0014763649,0.031309344,0.0448455,-0.0032556953,-0.04557848,-0.0022357695,-0.03875513,-0.102805,0.005120969,0.0345025,0.09311016,0.015913447,-0.04739369,0.042682514,0.07187605,-0.048009682,-0.08604592,-0.07747378,0.015887773,-0.0035490429,0.120450675,0.060270485,-0.027633002,0.0030591295,0.017918268,0.0056158067,-0.056188036,-0.05426963,0.08354815,0.025797095,-0.10722628,-0.1481822,0.02902605,-0.027463177,-0.011136283,0.018325994,0.08198239,0.04216241,-0.043783896,-0.13861614,-2.7479685e-34,0.08667684,0.089416794,0.0134018995,-0.042867746,0.032709017,-0.003531705,-0.085012935,0.0038665894,-0.0354552,-0.037692405,-0.011779787,-0.017996902,-0.00038103928,-0.030223163,-0.013074823,-0.00351798,-0.056572404,-0.021435434,-0.0010613023,0.0012157785,0.014699718,0.04020981,-0.005161261,-0.040285703,0.02326483,0.04402223,0.030761136,0.020490555,-0.031980086,-0.0012581471,0.05361542,-0.09195301,-0.10422385,0.045706507,0.09240786,-0.010465865,-0.07379327,-0.026973529,-0.033514593,0.07424542,-0.029075352,0.08529618,0.0045858077,-0.04590725,0.046088032,-0.09453256,-0.049358793,0.13414039,0.08144678,0.09847049,0.015071267,-0.024461558,0.07285946,-0.014709997,-0.010179368,-0.00019302775,-0.020502228,-0.026315197,0.01600027,0.05111957,0.019837115,0.01259073,-0.08758051,0.060421504,-0.015120633,0.03300557,-0.0048635723,-0.07062936,0.06038317,0.08867716,-0.02852497,0.010160223,0.050968826,0.06692828,-0.03325626,-0.04482074,0.0015186784,-0.027653685,0.01722481,0.020208409,0.0078079067,-0.07343444,-0.004080784,-0.020917442,-0.09481663,0.010041949,-0.024249969,-0.032114603,-0.017202323,0.011957725,0.032891367,-0.12854716,-0.046229564,-0.028123848,0.035630655,2.3416867e-34,0.05423812,-0.024289759,-0.04250987,-0.1391431,-0.015779996,0.11967275,0.02241312,-0.017117435,-0.042853482,-0.03442796,0.0453601,0.0331052,0.07948924,-0.0007898118,-0.003293104,0.0059678443,0.045941792,-0.04704932,-0.010091364,-0.021126214,0.011311496,0.11193671,-0.050791774,0.061166573,0.056345213,0.02361061,-0.020247806,0.11359121,0.06985613,0.029041024,-0.026535036,0.021816075,-0.044369802,-0.06714886,0.06464363,0.048996214,-0.07858439,0.05807866,0.007583295,0.022311792,0.005647707,-0.026701517,-0.036038794,0.058061663,-0.029055279,0.0831628,-0.13269755,0.003186861,0.103306346,-0.058922093,0.004336345,-0.0042775287,-0.015165541,0.045860108,0.003370589,-0.00897461,-0.03794044,0.027637813,0.02625985,-0.017474057,0.0008527056,-0.05618869,0.023529781,-0.05355646,-0.02747029,0.003682603,-0.037272677,-0.006742778,0.010744018,0.07309445,0.046774942,0.019842386,0.07454746,0.038448874,-0.079921685,-0.04072374,-0.029513765,0.024473527,-0.019465499,0.06408332,0.07381024,0.013427619,0.022633027,-0.10645412,0.06510598,-0.013654159,0.052076828,0.052979358,-0.06709576,0.02617507,0.029620664,0.02899341,-0.08651212,0.016166113,-0.028004907,-3.548403e-08,0.020438071,-0.083986156,0.057310563,-0.0015394306,0.011347772,0.044778425,0.031624027,-0.022997452,-0.043628786,-0.011308382,-0.026216537,0.10632423,0.0816567,-0.022938319,0.05454293,-0.00078393787,-0.045178395,0.014425795,-0.032558832,-0.053339284,-0.094607644,-0.036730688,-0.13469972,0.0099703595,0.04501103,0.0016853776,0.07940244,-0.033174366,0.019029066,0.010815388,0.0255862,0.037311103,0.03253074,-0.006930293,-0.10604109,0.05870636,-0.05098825,0.024596136,-0.072365515,-0.0071553197,0.03573415,0.024748124,-0.036256835,0.0510632,0.025164766,0.021476494,0.0022009022,0.00046356829,-0.0058946228,0.026327472,0.06575965,-0.04501902,-0.006634659,-0.029149469,-0.09856684,0.040901493,0.036332376,-0.0386305,-0.044160344,0.0007108695,0.0051639387,0.0039339247,0.16010249,0.0063991062 +1.14.14.35,"The enzyme, characterized from Pseudomonas spp., is involved in a dimethyl sulfide degradation pathway. It is dependent on NAD(P)H-dependent FMN reductase (EC 1.5.1.38, EC 1.5.1.39, or EC 1.5.1.42), which provides it with reduced FMN. The product, methanesulfinate, is oxidized spontaneously to methanesulfonate in the presence of dioxygen and FMNH2.",384,1.0,0.008959789,-0.014126751,-0.08452555,0.04636596,0.087493174,0.044571027,-0.072822556,0.10555486,0.049490694,-0.08117894,0.015114082,0.013909135,-0.09070718,0.089143224,-0.089002416,0.0299296,-0.060200583,0.0041966336,-0.015879044,0.00022650904,0.023049483,0.017962575,-0.0052920696,0.014493575,-0.03418452,0.016427552,0.06208593,-0.03151515,-0.024359116,-0.031108165,-0.02483201,-0.02178411,0.06178573,-0.015182111,0.008418772,0.08218139,0.051136855,-0.0035395778,0.034970094,0.009713467,-0.0028096081,-0.018290889,-0.019179463,-0.05785847,-0.003917544,-0.025306428,-0.0055218744,0.04443168,0.024520384,-0.022069724,-0.060432438,0.0098996125,-0.0061760177,0.090717465,0.06292989,0.08749224,-0.020150797,-0.032997888,-0.07508613,-0.004498957,0.03626425,-0.017013226,-0.013648972,-0.055784494,0.051318705,-0.007972203,0.08880315,-0.069672644,0.024738565,0.010745985,-0.12538622,-0.017451173,0.010046061,-0.00604072,0.014651624,0.047750123,-0.0012206841,-0.019289462,0.06650877,-0.047736842,0.053763185,0.03268601,0.031896707,0.038025703,0.039796107,-0.06893404,0.005760158,-0.028070927,0.04916329,0.011544205,-0.07989175,-0.0011096008,-0.02530049,-0.05132996,-0.105828464,0.032435473,0.013460335,0.09641043,0.02327756,-0.0392933,0.03920388,0.07104301,-0.117716335,-0.104448125,-0.06457178,0.02356791,0.00047272939,0.12832445,0.07842807,-0.0041394383,0.0116509395,0.06738336,0.014252404,-0.050278235,-0.045515887,0.07772216,-0.0045178966,-0.09696489,-0.11966941,0.057191927,-0.023708617,-0.011171193,0.031973537,0.08058158,0.016255459,-0.081078514,-0.1130741,7.383357e-34,0.04603117,0.060685582,0.019907434,-0.010847623,0.015303124,-0.028375568,-0.05367058,-0.027686505,-0.02138169,-0.0391723,-0.0102227125,-0.053654976,-0.032194726,-0.04383756,-0.013215419,0.008190884,-0.047087,-0.018416377,-0.003917564,-0.01883409,0.040716223,0.04781192,-0.0014891429,-0.040068414,0.062438775,0.018953754,0.013054621,0.014920114,-0.020372258,-0.003373124,0.049602587,-0.09471912,-0.11264056,0.0018381453,0.06101608,-0.018428054,-0.090492845,0.011789168,-0.01322525,0.08753351,-0.029692573,0.061863545,0.027794885,-0.027770858,0.03644823,-0.07186673,0.0025157423,0.1458266,0.064033836,0.045923892,0.020184573,-0.05552512,0.057766497,-0.010466681,0.0090902895,-0.049709283,-0.009007223,-0.027341817,-0.0041115796,0.0581783,0.060341787,-7.5936936e-05,-0.099489436,0.059814468,-0.026412474,0.016674409,0.016211146,-0.05931993,0.05095793,0.06348471,-0.024850542,0.030728947,0.07755015,0.0697035,-0.03483955,-0.0754054,-0.008990809,-0.010395671,0.04430978,0.04546293,-0.009622405,-0.06002368,0.01009413,-0.027614376,-0.108403176,-0.033529297,-0.0086375,-0.03886481,-0.032412168,0.021922385,0.0469925,-0.10044715,-0.040579937,-0.023310533,0.030724207,-2.1351436e-34,0.015886324,-0.011870464,-0.017623285,-0.09003155,-0.060445957,0.060231507,-0.03168681,0.048606485,-0.03032737,-0.04060349,0.07158546,-0.0036088992,0.04183413,-0.006404922,0.0050817113,0.05246791,0.020177113,-0.035160523,-0.0042804345,-0.02502753,0.008426768,0.1005441,-0.060364712,0.07880462,0.028462142,0.04855827,0.019442467,0.1276948,0.08991399,0.042659357,-0.016770843,0.021461444,-0.06575552,-0.047511265,0.051297933,0.0289764,-0.07859646,0.013217951,-0.010704843,0.019770864,0.037803333,-0.004879861,-0.016638624,0.027847143,-0.043280896,0.0783478,-0.1146989,-0.0031532012,0.11333153,-0.070469715,0.034414157,-0.00803504,0.0011060238,0.061669435,0.0066438667,0.009294168,-0.03922808,0.035533283,0.01597709,-0.019415785,-0.0042715427,-0.059686426,0.06029532,-0.038933214,-0.020975485,0.015000762,-0.021106394,0.0667351,0.011949851,0.082236044,0.063517876,0.040557165,0.059529588,0.02629009,-0.10288617,-0.029874792,-0.031001886,0.04924156,-0.007990245,0.034469288,0.085035294,-0.02562972,-0.013198782,-0.10631983,0.039929293,-0.022232046,0.053913057,0.099609666,-0.060038555,0.016250482,0.053254217,-0.0056719924,-0.078993104,-0.014400134,-0.036010608,-4.1847876e-08,0.0073068063,-0.08350399,0.036200706,-0.0077747866,0.0045664734,0.053299364,0.051726583,0.032577053,-0.021093518,0.041148584,-0.05636923,0.087904476,0.031359695,-0.07818357,0.012163795,-0.017466705,-0.054869685,0.040757168,-0.019415934,-0.064603336,-0.08684295,-0.023218252,-0.1301903,-0.0024863624,0.020839129,0.008945643,0.12548153,0.00038106454,0.028684432,-0.036269177,0.020054163,0.019130522,0.039526608,0.015216785,-0.12740429,0.010337135,-0.027007328,0.006037485,-0.088898435,-0.0010814392,0.009526365,0.052084237,-0.07406582,0.038365263,0.04558598,0.013656525,0.01853643,0.006359703,0.022692703,-0.021667555,0.070261635,-0.028882517,-0.034297515,-0.05082879,-0.110211015,0.021880785,0.025175586,0.008997566,-0.014849467,-0.01575088,-0.0066008056,0.004993389,0.13050659,0.02807019 +1.14.14.36,A cytochrome P-450 (heme-thiolate) protein. The enzyme from Sorghum is involved in the biosynthesis of the cyanogenic glucoside dhurrin. In Sinapis alba (white mustard) the enzyme is involved in the biosynthesis of the glucosinolate sinalbin.,384,1.0,-0.122753225,0.049855962,-0.08994436,-0.004708233,0.050376344,0.07511181,-0.08152957,0.037284207,0.027057812,-0.052689716,0.09596747,-0.04628146,-0.100788966,-0.036014393,-0.026622143,0.015694136,-0.0054767663,0.045809314,-0.042627793,-0.1516506,0.03968165,0.08118491,0.052525386,-0.006597242,-0.01804554,0.025517872,0.014711874,0.017627968,-0.030371899,-0.028842345,-0.042601913,0.011194467,0.032134805,-0.026627978,-4.9488815e-05,0.0837977,-0.026943553,-0.054244522,0.06727244,-0.027463019,0.096348695,-0.051057696,-0.026866356,-0.02820907,-0.03133233,-0.0003120262,-0.009919529,0.09213437,-0.016114194,-0.03784465,0.031096518,-0.013999189,-0.09673153,-0.037396293,-0.026345272,-0.015624491,-0.041045886,-0.050071206,-0.0123309055,0.026463822,-0.027796214,0.06352568,-0.088095225,0.05502818,-0.002220105,-0.05801209,0.0063565234,-0.058845777,0.008671927,-0.06951604,0.008156102,-0.14069921,-0.047570586,0.05340464,-0.08531916,0.09408715,-0.0118462015,0.026726535,0.0045071337,-0.07555113,0.06662305,0.04312781,0.06375616,0.12999581,0.033875354,-0.0150843505,-0.06573335,0.082937725,-0.048271593,-0.04718689,0.064957425,-0.027523609,-0.06472647,0.016511548,-0.031252913,0.05952914,0.0933093,-0.008414184,-0.012694761,-0.017154604,0.019771976,0.010212491,0.034066264,-0.09348275,-0.013533447,0.021695888,-0.051545948,0.05283515,0.09450942,-0.057179283,-0.04094898,0.013819416,-0.0415296,-0.0191434,0.010994027,0.038035378,0.0059655216,-0.01264075,-0.051122952,-0.04165321,-0.01893261,-0.01966092,-0.020783873,0.10696874,-0.06281264,-0.010132456,-0.09571271,2.8440886e-33,0.06676465,-0.0013448015,0.01926942,-0.037200525,-0.04436242,-0.03445343,-0.012900283,0.02572974,-0.052451987,-0.00413036,-0.06871364,-0.06919779,-0.009587176,0.022858685,-0.027142173,0.00781698,-0.06231253,0.01702248,0.08979059,-0.047101695,-0.057757065,0.061743345,-0.039460078,-0.02307311,0.01970026,0.10417953,-0.0016758617,-0.05197539,0.026993768,-0.010376564,-0.00024169624,-0.075327806,-0.033150297,-0.052957546,0.020676801,-0.0039644083,-0.051943116,-0.05724552,-0.07081425,0.061268434,-0.03885471,-0.016366981,-0.015124582,-0.0474071,0.013535845,-0.0015466558,-0.08353568,0.04449551,-0.021366527,0.06150449,0.07563795,-0.035566863,0.13272657,0.07672305,-0.04837526,0.045540407,0.033079416,0.025685735,-0.0337442,0.05332933,0.0469142,0.0427176,-0.043330997,0.056845948,0.049728848,0.031712424,-0.061931316,-0.040746365,-0.03310164,0.10701845,-0.03190501,0.0010936543,0.05008339,0.0040845615,0.025603112,0.0066738175,-0.01048094,0.06365742,0.0035153832,0.050429534,0.055191547,0.029108366,0.016269501,-0.04971229,-0.058211423,0.029197989,0.027242245,-0.033683214,-0.033231918,0.025668979,0.055760283,-0.03946518,-0.02569421,0.045570027,0.0011089246,-4.117366e-33,0.053684838,-0.061596915,0.048894055,-0.083299786,-0.05263439,0.046625335,0.051027358,-0.07069707,-0.014618098,0.0557718,0.09681505,-0.020204684,0.044214554,-0.05304032,-0.006829043,-0.0115102865,-0.05306047,0.119270384,-0.0008166878,0.0869915,-0.008533341,0.03299848,0.04096173,-0.04527162,0.01777928,-0.0076190764,0.025094151,-0.0003558525,0.007905848,0.003650978,-0.020013765,0.020852655,-0.094100796,-0.070400134,0.034257863,0.052623946,0.024237081,0.042665966,0.021708181,0.0047815936,-0.0542466,0.085657716,0.0358837,0.08676901,0.101668425,0.059379518,-0.066161364,0.0007005899,-0.08866472,0.028938629,0.054279923,0.044036943,-0.014539398,0.056521986,0.005473436,0.0157211,0.040148504,-0.0019772435,-0.048185606,-0.07844208,-0.092373125,-0.06484167,0.00065424945,0.027365416,0.06403945,0.08041643,-0.027245719,0.0509145,0.03441333,0.010703782,0.05778446,-0.040408466,0.033961304,0.005289923,-0.012958225,-0.027598001,0.028631445,-0.020803753,-0.018881543,0.01974934,0.009287812,0.021312248,-0.011902234,-0.031453796,-0.016360387,-0.061725806,0.021039892,0.16907242,0.05424159,0.027167547,-0.026150744,0.0422076,-0.021436574,0.06838453,0.06174876,-3.5414615e-08,-0.04037847,-0.045187768,0.024529643,-0.016378535,0.025874939,0.033676453,0.048137926,0.00091089,0.03378876,0.0119255325,-0.0124588255,0.08042388,-0.058611248,-0.043542195,-0.024827642,-0.008987013,-0.045091633,0.008418593,0.07004022,-0.028269822,0.0070877587,0.0194328,-0.04192371,0.020599551,0.00916498,-0.11475497,0.043889493,0.02224173,0.041331153,0.049948115,0.006017614,-0.0045336653,-0.062017605,-0.04491034,0.013545259,-0.0034090106,-0.060240347,-0.03412308,0.04781494,-0.016717412,-0.07946726,-0.022097051,-0.019024389,0.014347168,0.044222835,-0.0427815,0.03378746,0.052844338,0.00436672,0.02912735,-0.06745772,-0.028604638,-0.0019107661,-0.14348768,-0.115388654,-0.025961405,0.07647666,-0.0478921,-0.03598157,-0.049766514,-0.013117697,-0.0068905675,0.16042565,0.01027136 +1.14.14.37,"This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum. It catalyses three different activities - isomerization of the (E) isomer to the (Z) isomer, dehydration, and C-hydroxylation.",384,0.99999994,-0.12590833,0.028916849,-0.06793221,0.005232014,0.060397264,0.02695567,-0.096626416,0.026194554,-0.01253613,-0.04779412,0.09311403,-0.01935315,-0.111117765,-0.05928174,-0.036956944,-0.009698444,0.0024043855,0.076064795,-0.0482808,-0.118898354,0.057510182,0.030413728,0.03580354,0.014344028,0.050550714,0.0028273962,0.014413588,0.055192538,-0.03580642,-0.040127482,-0.017651862,-0.007119585,0.03506106,-0.02332999,-0.020968981,0.08740159,-0.038774986,-0.05526729,0.059389893,-0.085520014,0.10299018,-0.09200867,-0.047987126,-0.052695386,-0.028515087,-0.0455029,-0.030308936,0.061645534,-0.02881232,-0.048993982,0.031064432,-0.019537758,-0.0736422,-0.022927662,-0.054667313,-0.035910822,0.0024057664,-0.007827875,0.009951866,0.021705737,-0.00602231,0.044301316,-0.09758018,0.060568675,0.0176925,-0.06457898,-0.010491157,-0.07197266,0.015452059,-0.06302238,0.0026403936,-0.13230734,-0.016614549,-0.009229426,-0.094532564,0.11412058,-0.017294193,0.00095182593,0.012277685,-0.02760355,0.08999509,0.023784583,0.09118691,0.1075176,-0.013513489,-0.024709987,-0.07727718,0.06426162,-0.032016266,-0.051887512,0.07340357,0.050855726,-0.06517042,0.034547076,-0.072871596,0.0733292,0.07450063,0.025330536,0.005967728,-0.014528464,0.03232788,0.064124815,0.0013685927,-0.08481185,0.020550368,0.017931549,-0.026098263,0.06100064,0.083078735,-0.045207918,-0.048235647,-0.04678406,-0.059332337,-0.007095217,-0.034312688,0.059853,-0.01945732,-0.010449961,-0.07711622,-0.046948604,-0.029593447,-0.0040969267,0.013820202,0.061857436,-0.034256656,-0.031565856,-0.03431366,2.3053762e-33,0.04155176,6.130495e-05,0.013139527,-0.05428974,-0.023931049,-0.014696873,-0.027474133,0.0418133,-0.0095180385,-0.040468995,-0.06105268,-0.0728469,-0.0054092184,0.0009388678,-0.053641044,-0.033172555,-0.048072618,0.023205398,0.11435815,-0.034640495,-0.014088005,0.026179273,-0.05752584,-0.030534886,0.01781121,0.0736561,-0.01376561,-0.022001648,0.04614051,-0.014334893,0.057120457,-0.05745966,-0.058771048,-0.05630132,0.029364021,0.02461264,-0.035164423,-0.0017972224,-0.037887182,0.041865684,-0.08016244,-0.012930071,0.009602109,-0.07088843,0.01726286,0.030942775,-0.076736785,0.043128878,-0.01746655,0.046182945,0.09684351,-0.03840328,0.0878661,0.08754762,-0.0497603,0.025188291,0.028072251,0.008442653,-0.005222961,0.057776634,0.08277414,0.07227317,-0.0027120176,0.054123376,0.030579679,0.021564137,-0.05627043,-0.01862352,-0.015768679,0.11168332,-0.06521608,-0.0095113125,0.07277494,-0.0013206543,0.008216656,0.02037469,0.0032714002,0.038137812,0.020833064,0.01673286,-0.015184737,0.03520651,-0.0007082034,-0.011233393,-0.014821916,0.04938621,-0.058529463,0.0066665113,-0.012680401,0.065141425,0.07251733,-0.03297111,-0.014556517,0.034306683,0.023432443,-3.6328146e-33,0.070709005,-0.03780457,0.0072809523,-0.08195783,-0.050533794,0.039524186,0.015124011,-0.045348294,-0.024666384,0.062101148,0.09211804,0.0035535006,0.011001595,-0.0495046,-0.024397476,-0.019690199,-0.038580325,0.12005133,-0.02573622,0.07785482,0.021970348,0.049003437,0.029725984,-0.027911495,0.03833949,-0.017379262,0.05108777,-0.028803298,0.06869891,0.039914798,0.0035155702,-0.009303007,-0.09057325,-0.063342616,0.04936961,0.06438636,0.020754213,0.04779747,0.024241256,0.008821149,-0.08434582,0.052435447,0.020958135,0.06807206,0.11106486,0.06888434,-0.06977499,-0.0124511365,-0.06765437,0.03032183,0.0814751,0.074476294,-0.07203896,0.04432871,0.034444623,0.034345977,0.067214094,-0.034912646,-0.09564862,-0.105992235,-0.08759728,-0.014371311,0.013509864,-0.03380109,0.039873056,0.08411184,-0.005775085,0.06277383,0.00792535,-0.01711891,0.06205627,-0.04760062,-0.005664008,0.022165144,-0.009453366,-0.014247436,0.08619635,-0.019376867,-0.0074153454,-0.0113085415,0.013675272,0.0032431025,0.0031906464,-0.04923271,-0.036701806,-0.09932843,0.0016499513,0.15748107,0.05708021,0.033420805,0.0020428498,0.02551814,-0.00032117753,0.05641116,0.045317102,-3.497007e-08,-0.075760484,-0.07199996,0.05162383,-0.013500531,0.016283797,0.0334946,0.043646675,-0.014176166,0.0750802,-0.024134418,-0.0050864276,0.08862605,-0.049105298,-0.033938974,-0.021835037,-0.0337195,-0.015785547,0.027729493,0.049138077,-0.021816455,-0.05279998,-0.036726296,-0.09486245,-0.0108616995,0.058949385,-0.111832246,0.0116362525,0.011930621,0.036469482,0.04210334,0.051539294,0.031582266,-0.026429635,-0.0063709132,0.044573482,-0.008407755,-0.020691592,-0.019856516,-0.0046046483,-0.0054267156,-0.09511731,-0.07514968,0.006471371,0.0067727873,0.022590972,-0.022564728,0.046806667,0.04657588,0.015287692,0.06366102,-0.06716674,-0.04867156,0.028500801,-0.11113762,-0.050639104,-0.019910417,0.0827709,-0.039713483,-0.033408385,-0.03332949,0.050710864,-0.010417593,0.1262611,0.013143946 +1.14.15.21,"A flavoprotein (FAD) that is active under conditions of low light. Along with EC 1.23.5.1, violaxanthin de-epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle, which is involved in protecting the plant against damage by excess light. It will also epoxidize lutein in some higher-plant species.",384,1.0,-0.029860986,-0.048501734,-0.06365747,0.036209803,0.1508303,0.015885985,0.02356967,0.08710634,0.050189007,-0.0010332222,0.101239316,0.022069264,-0.037467517,-0.052245755,-0.0721767,0.0505352,-0.05599713,0.0060008266,-0.100963786,-0.00022426019,0.018050738,-0.030225655,0.046125785,-0.033680845,-0.014880485,-0.022857927,-0.038718287,0.004023509,0.035650432,-0.029884186,0.073817395,0.08436466,0.042685736,0.034346413,-0.044657927,0.057710823,0.065438606,-0.07015878,-0.0028000167,0.010890647,0.0085028745,-0.031532463,0.016413713,-0.033112746,0.02057055,-0.010825802,-0.0045954003,0.022613985,-0.07147902,-0.018481713,0.046525173,-0.06629732,-0.052321777,0.026410503,0.001366655,0.015508661,-0.008858198,-0.048791286,0.0083068255,0.0070721656,0.073089145,0.010262871,0.019247476,-0.002940757,0.037399966,-0.032794356,-0.056278404,-0.052745532,0.04995112,-0.038408507,0.0032020253,-0.050929703,-0.018349804,0.0428498,-0.020594364,0.04194416,-0.082388066,-0.02265247,0.048205048,-0.002956722,0.07860451,-0.007922623,0.051152736,0.077988446,0.08643794,-0.038674258,0.024908453,-0.003689145,-0.035943072,0.0567762,-0.024389768,0.01633435,-0.0099918675,0.043254077,-0.074602835,0.07738731,0.07747093,-0.11951288,-0.07751335,0.017110236,-0.045971602,-0.0065076225,0.01599161,0.012232875,-0.06591751,-0.12304904,-0.033145804,0.058623783,-0.08140485,-0.092640415,-0.030273367,-0.040567327,0.0037253941,-0.052941095,-0.024804873,0.023497822,-0.018910302,-0.035567723,0.0035896641,-0.014451841,0.028621627,0.04005751,0.031189488,0.08348957,0.068266846,-0.036711965,-0.06189581,2.0086605e-33,0.08503705,-0.0023637202,-0.060030464,-0.051562347,0.014875747,0.008691324,-0.02263557,-0.0010388982,-0.031756632,-0.03638253,-0.040444966,-0.021922331,0.02163558,-0.034827884,0.04996397,-0.033018604,-0.06674078,-0.011810873,0.08913183,-0.11086318,0.015246263,0.0012384492,-0.061085332,0.04268229,-0.0021544609,-0.0010812297,-0.03366569,-0.004721747,0.006778192,0.032238625,0.001039971,0.0077144196,-0.029794531,0.061100654,-0.04976809,0.1083837,-0.07951696,-0.08215179,-0.057379156,0.09609277,-0.016438842,0.018111112,0.041767996,-0.03268182,0.07194785,-0.020437164,-0.109770745,0.072595865,0.012239776,0.10750084,0.031129127,-0.027475469,0.08935433,0.030152144,-0.061329957,0.061152607,-0.034386437,-0.014222413,-0.040858414,-0.012174835,0.027241917,0.0099889105,-0.06421636,0.063854225,-0.02099946,0.012414692,-0.03047226,-0.080148585,-0.0211526,0.09916703,-0.04430248,-0.043663986,0.073262125,-0.044571,0.06104753,-0.025423726,-0.036849763,0.03010833,-0.023703733,0.016795471,-0.047347676,-0.022167826,-0.05204464,-0.06914085,-0.0285738,0.028630273,-0.05314523,0.009440807,-0.02151924,-0.009615996,0.100760475,-0.042260904,-0.00030991551,0.0087234555,0.022314694,-1.1558553e-33,0.0394751,-0.073210016,0.055723656,0.05685575,0.055284552,0.072116725,0.008226582,0.00915607,0.0077765635,-0.00061339873,0.051549487,-0.02434011,-0.05534483,0.010490233,0.016897047,0.01824295,-0.0023452954,0.034953944,0.053844865,0.03618368,-0.10658847,0.06710572,0.053168237,0.046333507,0.026684415,-0.017500391,0.043718137,-0.012678183,-0.012785691,-0.0005486804,-0.06336572,-0.016254796,-0.041797414,0.021847475,-0.04988193,0.036775496,-0.00924145,-0.03894059,-0.082557105,0.04364904,-0.013374853,0.01792541,0.015000563,0.044881005,0.036431327,0.063262925,-0.06708511,0.034790814,0.057081748,-0.023354797,0.030924667,0.028153436,-0.0020002923,0.08148773,0.037477795,0.0387442,0.04930385,0.07178429,-0.074336246,0.070681974,0.035545122,-0.073240675,0.01299665,0.032864034,0.0719747,0.04163254,0.012480657,0.14161953,0.001489772,0.017255986,0.15593001,-0.01646452,0.002878109,0.040260274,0.013060823,-0.05228188,-0.03334287,0.0535472,-0.04245931,0.014950556,0.016063018,0.02308281,-0.014734042,0.028567826,-0.092865,-0.1159411,-0.045592405,0.08975255,0.021307133,0.0048795133,-0.035397332,0.06603981,-0.022280177,-0.03315317,0.14059293,-3.4412697e-08,-0.03212045,-0.045249797,-0.0009656287,-0.06359938,0.094125815,-0.043406997,0.007374877,-0.013316597,0.0129619,-0.05759488,-0.022102265,0.09436235,0.0032385553,-0.010603676,0.054232456,-0.03338821,0.038631026,0.04514208,-0.04184427,0.0066519612,-0.11177045,0.018616023,-0.040175285,-0.03302829,-0.026456045,-0.027140602,0.032641422,0.018496701,0.048061337,0.0009079628,0.037175566,0.045054015,0.043965057,-0.035814393,-0.19662799,0.07203234,-0.007309849,-0.085815124,-0.057870492,0.064147994,-0.07857026,-0.035064287,-0.006085469,-0.046118177,0.0034784463,0.02361482,0.079695225,-0.050857984,-0.039343957,-0.013889692,-0.012193488,-0.026919877,0.01516147,-0.017580261,-0.10495605,-0.0031325738,0.015605053,-0.0356564,-0.019404583,-0.06847288,-0.0019960473,0.027699456,0.15696526,0.03710261 +1.14.15.22,"A P-450 (heme-thiolate) enzyme found in the bacterium Streptomyces griseolus. cf. EC 1.14.14.24, vitamin D 25-hydroxylase and EC 1.14.15.18, calcidiol 1-monooxygenase.",384,0.99999994,-0.06973266,0.011405922,-0.12381677,-0.03527552,0.030803509,0.049662985,-0.0404131,0.073475026,0.031143477,0.00062775373,-0.016558738,-0.061215416,-0.01572416,0.06883813,-0.06702857,-0.085959196,-0.057328705,-0.04434446,0.077916004,-0.0860943,0.031862866,0.10020606,0.013539077,0.004487135,0.046273313,0.03089941,0.04390401,0.019215167,-0.09460916,-0.025865339,0.016069207,-0.048908945,0.09398136,-0.012649725,0.05638052,0.14026672,-0.067421876,-0.02721894,0.06851707,0.009667986,0.0016785329,-0.031995427,-0.03038836,0.0619051,-0.07379812,0.013652792,0.017277852,0.08064117,-0.004086063,-0.042753037,-0.02678643,-0.0526769,-0.06267073,0.024660744,0.06191901,-0.017071381,0.08250456,-0.017589333,-0.01769159,-0.046127327,0.037292656,-0.017272891,0.02859729,0.0011003719,-0.06169584,-0.0013616938,0.04683084,-0.094410025,-0.0047700335,-0.07507929,-0.07461977,-0.03161963,-0.00037792767,0.03631439,-0.07929227,0.044628743,-0.029813174,-0.0508983,0.031556357,0.012932964,0.046274226,-0.0017389574,-0.03448553,0.09351886,0.04202093,-0.026920019,0.022631507,0.036285073,0.04293187,-0.015249021,0.034803797,-0.004949499,-0.028863,-0.042093027,-0.085698895,0.019466637,-0.0754094,-0.016729943,0.01000776,-0.06236012,-0.04485254,0.03583642,0.038328215,0.010300943,-0.05272679,0.0121422075,-0.032495987,0.10172071,0.042235896,-0.051889285,-0.015274613,0.021621523,0.024567595,-0.0011677142,0.043901175,0.048026267,0.06918826,-0.04564178,-0.094427615,-0.021313809,-0.018836368,0.0017743204,0.05417051,-0.009082889,-0.04267804,0.027309563,-0.059142098,1.4626214e-33,0.040011007,0.035525482,0.0037144036,-0.040272936,0.039494496,0.035715736,-0.087061904,0.06052508,-0.017860211,-0.05311496,-0.04909877,-0.1012428,0.021483235,0.031220637,0.0051714093,0.0152437175,-0.032062665,0.040699597,0.048968166,0.008877829,-0.012193352,-0.015707018,0.0023759517,0.012142113,0.020134294,0.10771798,0.008486132,0.06379852,0.10640867,-0.03956262,-0.0014171604,-0.0934268,-0.055603053,-0.037574638,0.06476302,-0.0020528487,-0.037791748,0.011976548,0.0011351025,0.077113315,-0.026452517,0.03289081,0.082168125,-0.033991918,0.050175477,-0.06124124,-0.11067547,0.116743065,0.04055677,0.08563275,0.00053154066,-0.008123046,0.09263626,-0.014811921,-0.07283399,0.041340403,0.03050355,0.082376994,0.047073357,0.014875107,0.0968899,0.068021536,0.029114831,0.00062369416,0.018183362,0.028450493,-0.040556025,-0.01951368,0.007795248,0.11753299,-0.028664567,0.016800022,0.075990215,-0.07186482,-0.0036488099,-0.03174417,-0.031519506,-0.008006531,0.04909807,-0.028456988,-0.011961932,-0.022751944,-0.0029129335,-0.037465498,-0.02588199,0.023708064,-0.040535036,-0.034182206,-0.00426843,0.03763867,-0.00865792,-0.083191514,-0.05116753,-0.008774464,-0.006071041,-1.1622055e-33,0.10634786,-0.07768841,0.065438755,-0.0613696,-0.027479056,0.09221641,-0.00047689807,-0.019723747,-0.07984232,-0.014235755,0.11086183,0.0047712424,-0.030888986,-0.051363997,0.03801591,0.032471098,0.0031183485,0.03832696,-0.015020339,0.021649143,0.052979425,0.045462966,-0.014021079,-0.016740676,0.04931177,0.016508885,0.007040411,0.015146822,0.017124746,0.003095599,-0.028495047,0.01890931,-0.06709702,-0.03932732,-0.04780684,0.052528232,0.0039649396,0.014428532,0.051004015,0.011177254,-0.0039102403,0.057299476,0.044985756,0.14300922,0.052875355,0.08429717,-0.07280634,-0.0015091329,0.017456073,-0.0065672966,-0.038797498,0.02049177,-0.05471026,-0.008700298,-0.025604498,-0.010513077,-0.007198053,0.037714295,-0.057943616,-0.09422887,-0.04655621,-0.057288624,0.023155298,0.049638703,0.04085388,0.03485618,-0.039736,0.087886535,0.07877963,-0.014241788,0.04447405,-0.05479258,-0.0024631864,0.008285506,-0.018176675,-0.0059459154,-0.038113665,0.031859882,0.06907076,0.0577489,0.04715431,0.0079883635,-0.058064453,-0.034406874,-0.012988401,-0.1334401,-0.003832126,0.05699517,0.009757919,0.047672268,-0.09767179,0.054228485,-0.04539156,-0.0055371323,0.08910092,-3.421203e-08,0.01951507,-0.055123124,0.025568603,-0.011552808,0.081550844,-0.026982319,-0.02250088,0.013002181,0.07905209,-0.030862786,-0.021340232,0.012702362,-0.03470134,0.03112916,0.0067821112,0.03265444,-0.088956416,-0.01060008,0.0019331761,0.017563043,-0.06374242,0.020396054,-0.06815398,0.031364486,0.019438313,-0.06521096,-0.032811876,-0.035226364,-0.011059575,0.045993917,-0.01128557,0.037322026,-0.05052672,-0.064692505,0.04794813,0.021234596,-0.08884966,0.017530363,-0.04295518,0.043801833,0.01499444,-0.06806865,-0.07144615,0.008501482,-0.03553177,0.051551733,-0.018188234,0.023967998,-0.07594431,-0.014134089,0.06359842,0.024494672,0.0015792232,-0.01927796,-0.17509286,0.08208947,0.050666213,-0.10302848,-0.0807236,-0.05125128,0.01691113,-0.016411623,0.18090612,-0.034399703 +1.14.19.48,"The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, is a Rieske nonheme mononuclear iron oxygenase. It can also act, with lower efficiency, on butan-2-ol, converting it to but-1-en-3-ol. Depending on the substrate, the enzyme also catalyses EC 1.14.13.229, tert-butanol monooxygenase.",384,1.0,-0.092999235,-0.018611817,-0.08530927,0.04172221,0.09009556,-0.0175363,-0.07090164,0.037297096,0.05197388,-0.052145623,-0.010786767,-0.055140525,-0.031806763,0.019360473,-0.084283516,0.01397335,-0.021719964,-0.009008808,0.06272795,-0.014763555,0.0042429534,0.03601309,0.023235532,-0.012422337,0.052838374,0.005705201,0.031312753,-0.023932343,-0.058364928,-0.06464793,0.007532321,-0.0723787,0.031055849,-0.02840085,-0.00707727,0.07411018,-0.03967134,-0.04427457,0.012038954,0.019996705,0.012323847,-0.017759621,-0.07151248,-0.03137675,-0.028126482,-0.059633177,0.013861157,0.022204498,0.07441062,-0.00551722,-0.020104576,-0.039428394,-0.0814595,0.03986509,-0.0198104,-0.034576334,-0.006350519,-0.024529785,-0.05915376,-0.009966673,0.028080517,0.023076486,0.0058119525,0.06452572,0.012041207,0.013698019,-0.022480443,-0.027773071,-0.05219362,-0.07960913,-0.020167202,-0.053403527,-0.04584264,0.001844942,-0.01003318,0.017972846,0.048835766,-0.011626823,0.06772071,0.015986562,-0.029727733,0.0013788404,0.031293027,0.053057488,0.05973517,-0.01344136,0.019555036,-0.04018523,0.07001609,0.047055434,-0.030193219,0.05621681,-0.010431772,-0.019298937,0.0005274883,0.021249088,0.035230394,0.08728869,0.040452406,-0.011927895,-0.04422139,0.09867601,-0.038218193,-0.10205444,-0.072714634,0.00798703,-0.04169385,0.04708446,0.122363076,-0.018950962,0.03091369,-0.07653781,0.071045384,-0.0056266966,-0.003712696,0.06324971,0.03908044,-0.038258117,-0.094106704,0.06013316,0.035519946,0.014294528,0.012152622,0.059630156,-0.034690678,0.059065334,-0.092251636,7.3619195e-34,0.051028334,0.01160356,-0.011584908,-0.040069107,-0.011744339,0.05422774,-0.08314319,0.030264469,-0.12790993,0.0016807575,-0.064540334,-0.043593507,0.02347444,0.004339106,0.018311622,-0.08275345,0.053757083,-0.009937255,0.025595522,0.0028659978,-0.024766164,0.076996624,-0.03882315,0.02279512,0.038702786,0.046791904,0.0046918923,0.016974773,0.027786924,0.010774299,0.029812979,-0.11315959,-0.14065135,-0.031099634,0.062411267,-0.03222071,-0.05141512,0.021833377,-0.039705124,0.035578236,-0.030669965,0.06835965,-0.01342234,-0.084834546,0.071182586,-0.068809934,-0.017405342,0.15178014,0.03907443,0.08848441,-0.03306199,0.02992917,0.07301575,-0.01600949,-0.05775497,0.046538003,0.020629883,0.07792893,0.054239172,0.023036782,0.021267345,0.044839356,-0.006404631,0.04856447,-0.030956332,0.0057393108,-0.051930588,0.029341202,0.032736536,0.082494855,-0.03751672,0.071770325,0.055552203,-0.030756125,0.04971608,-0.05345044,-0.04411751,-0.046861015,0.079746224,-0.067882635,-0.058187257,-0.01654748,0.051401146,-0.059970025,-0.067404024,0.028450666,-0.062077813,0.049582012,-0.049978558,0.05148802,0.10051338,0.006663203,-0.113806166,-0.06718933,0.021865914,-7.676647e-34,0.10201876,-0.11542037,-0.028332729,-0.11798881,-0.03701254,0.047987856,0.003396422,0.04513987,-0.029231245,0.0022522744,0.12617782,-0.017404692,0.06128646,-0.08668524,0.026589531,0.06656133,0.017786447,0.09693141,0.003060502,-0.022400025,0.048160028,0.05171556,-0.05162734,-0.0164426,-0.026792021,0.03127171,-0.10452936,0.0260818,0.049774982,0.07758868,-0.040199194,0.04176158,-0.012928301,-0.054111324,-0.015883366,0.044385206,0.009278013,-0.0071836943,0.02486775,0.037947327,0.019473491,0.0046313875,-0.023814412,0.098125115,0.050054867,0.07471706,-0.12366988,-0.0070395204,0.016085431,-0.022021817,0.008511149,-0.008464496,0.03742213,0.024757745,0.01076711,-0.007193053,-0.013842818,-0.034352228,-0.040171597,-0.05890764,0.030074906,-0.09739744,0.04652594,0.022858454,0.029049672,0.042848054,-0.05003244,0.010020895,0.039935257,-0.037076153,0.09887219,-0.01915289,-0.036749955,-0.022755146,-0.025839651,-0.05251266,0.031950813,-0.008913771,-0.009951337,-0.00088626164,0.014850363,-0.012295201,0.01370694,-0.046581935,-0.0022589848,-0.06730085,0.034867592,0.071731865,-0.024809422,0.080860175,-0.04535745,0.023673344,-0.046753395,0.03187932,0.09567359,-3.9231544e-08,-0.018870702,-0.11801056,0.048258025,-0.007290959,0.017196622,0.06252219,0.03310028,-0.03842192,0.00104253,-0.0038050292,0.05139686,0.08016831,0.008609788,-0.010568369,0.10799775,0.012699249,0.07785849,0.02436098,-0.009318999,-0.0064286813,-0.025123356,0.057761293,-0.07769374,-0.0025264982,-0.016522974,-0.060101774,-0.065382235,0.0027702255,0.0009888969,-0.052991413,-0.097134806,0.05807776,-0.00517168,-0.040084563,-0.12989274,0.031434983,-0.040610738,0.0039924844,-0.037253585,0.011400537,-0.0384762,0.010362665,-0.05990626,0.006476233,0.010010113,0.01179229,0.06856084,-0.011733589,-0.028248433,-0.024570104,0.029822515,-0.024178466,0.06218909,-0.02782135,-0.077754766,0.08094071,0.008034576,-0.03977333,-0.07492887,-0.05356885,0.042659458,-0.016643032,0.17682065,-0.061067916 +1.14.19.49,"The enzyme, characterized from the bacterium Streptomyces aureofaciens, is a member of the flavin-dependent halogenase family. The enzyme forms a lysine chloramine intermediate on an internal lysine residue before transferring the chlorine to the substrate. It is stereo-selective for the 4S (natural) isomer of tetracycline. FADH2 is provided by a dedicated EC 1.5.1.36, flavin reductase (NADH).",384,1.0,-0.05788439,-0.04251529,-0.1914144,-0.0012240409,0.117544584,0.03890222,-0.060313713,0.061040375,0.06070304,-0.07097624,0.00021771003,-0.10134163,-0.05074338,0.07809529,-0.067038186,-0.015956812,-0.07220187,-0.06712936,0.04835399,-0.04926661,0.018232731,0.057768993,0.0005891806,-0.011586497,0.012003143,0.003607291,0.022374071,-0.0733999,-0.031164745,-0.04959692,0.06444326,-0.025057528,0.07747765,-0.025863552,0.027232027,0.09120448,-0.023449712,-0.05215714,0.060734876,0.007229263,-0.05063926,0.016466325,0.047132045,-0.03695203,-0.027276095,0.054882016,0.05491276,0.08986346,-0.016481953,0.08006897,0.033527236,-0.07072831,-0.08852359,0.053858683,0.026594367,0.033680625,-0.06273574,0.0032625427,-0.010108665,-0.010655625,0.09551968,0.035280295,-0.021585872,0.01126977,-0.006414768,-0.026190314,0.027464906,-0.10132163,0.05557274,-0.058024228,-0.031983163,-0.02279659,0.009269946,0.017839143,0.023697961,0.018580414,-0.000104206534,-0.0020907829,0.013620372,-0.00040594724,0.03919693,-0.033074316,0.02055531,0.10427438,0.06266508,-0.04443034,-0.039124195,-0.010782929,0.01620499,0.015037059,0.05153188,-0.017851219,-0.0086014755,-0.04606125,-0.085959025,0.041930757,0.002600695,-0.008012384,0.006801819,0.012346014,-0.03670982,0.022381183,0.015620516,0.009511679,-0.07168318,-0.035467286,-0.004074414,0.08327178,-0.0026593443,-0.078529514,0.020329166,0.033632573,0.050370008,-0.033079095,0.0058893976,0.07528438,0.021820985,-0.12856914,-0.07365225,0.049087875,-0.0057917945,0.073066324,0.051361926,0.086112425,0.06025854,0.011085054,-0.15035911,2.5810144e-33,0.04501149,0.047615636,0.0356431,-0.075068794,0.0081683,-0.02876551,-0.05716766,0.017727278,-0.029715592,-0.050050803,-0.03187127,-0.030060947,0.08691584,-0.028292576,0.04308764,-0.027100071,-0.020516455,-0.000443685,0.06734356,0.0016391133,-0.033971645,0.10884225,0.0012543075,0.041375205,0.020420829,0.06258169,-0.015281892,0.027312541,0.06368724,0.043400325,0.0108962655,-0.089167744,-0.072954066,-0.0055698375,0.030163383,0.027041078,-0.123739794,-0.04841023,-0.01593792,0.059698902,0.016712697,0.044832405,0.007621084,-0.016193375,0.047287393,-0.10946195,-0.03847316,0.09159216,0.024031807,0.08020365,0.041359264,-0.038782418,0.05879132,-0.038809042,-0.07094761,0.07576897,-0.03978831,0.020224193,0.020679982,0.023322113,0.0737155,0.038814653,-0.0667437,0.053884495,0.0057469527,0.0033808094,0.02076221,-0.09291131,0.03383587,0.06085761,-0.034251552,-0.025889082,0.0969508,0.04293346,0.0579249,-0.021054776,-0.018109933,-0.014404287,0.037857108,-0.0077683856,-0.03917246,0.011957955,0.04480837,-0.052804437,-0.08110745,-0.015995799,0.008194183,-0.06424332,-0.03634159,0.042377446,0.0029333623,-0.097936906,-0.033781305,-0.040360462,0.03133828,-2.3407167e-33,0.05153308,-0.083183505,0.015849581,-0.08265033,-0.008328455,0.07421733,0.0036265992,-0.061679173,-0.008557284,0.0028560888,0.07434294,-0.0122948075,-0.012204843,-0.030881125,0.07790437,0.01168991,-0.036166593,0.035404935,0.037732318,0.015407679,0.042359933,0.048452336,0.06619436,0.014273232,-0.012306621,0.016671514,-0.024826702,0.06761625,0.0965296,0.06338689,-0.11963981,0.008969407,-0.015769983,-0.060167015,-0.039173163,0.04482757,-0.06536733,0.024815017,0.013811557,-0.008401095,0.046593603,0.04059895,-0.010341558,0.016707843,0.014936126,0.08588512,-0.059818786,0.023852678,-0.0019840999,-0.101032235,-0.025521014,0.0109878285,-0.012746466,0.012786237,0.01746232,0.039516494,-0.016066993,0.029250445,-0.0016612053,-0.017848792,-0.016165115,-0.07992746,0.01109181,0.02107128,0.09249037,-0.03289566,-0.0366387,0.07657356,0.034253437,0.009308731,0.05801444,-0.043128416,0.052525487,0.055248525,-0.03927645,-0.0919303,-0.08612568,-0.011197806,0.002651964,-0.0330852,-0.0015057287,0.015583335,0.06804881,-0.038482703,0.010380408,-0.10476168,0.0053908415,0.061083782,0.026745787,0.037572768,-0.030779466,0.020518763,-0.008158128,-0.019644763,0.07973979,-4.1376428e-08,0.030051839,-0.05637889,0.06818709,-0.0067432397,-0.0027243905,0.049291458,0.009766773,0.0049735177,-0.05144715,-0.017346757,-0.035304915,0.043064333,0.060680084,-0.0509263,-0.008454618,0.06101931,-0.04834386,-0.02937629,-0.04996901,-0.022838823,-0.08809784,0.03710193,-0.06385772,-0.014896685,-0.023303706,0.02466495,-0.020029584,0.012987134,-0.014923534,-0.018624747,0.027952844,0.04589594,0.013137839,-0.055779275,-0.15110916,-0.034869112,-0.022680335,-0.039258376,-0.049706962,0.07149152,-0.014306435,0.05751942,-0.08609774,0.05223247,0.038973883,0.007899285,0.058177333,-0.006717003,-0.04090289,-0.03794654,0.029370926,-0.020583304,-0.061063994,-0.0035681704,-0.072401814,-0.011482789,-0.03131513,-0.092559814,-0.036724787,-0.067999244,0.042281043,0.07835957,0.18086262,-0.014769785 +1.14.19.50,"A P-450 (heme-thiolate) enzyme. The enzyme, characterized from Narcissus pseudonarcissus (daffodil), forms the two enantiomers of the Amaryllidacea alkaloid noroxomaritidine by catalysing intramolecular oxidative para-para' phenol coupling. The oxidation involves molecular oxygen without its incorporation into the product.",384,1.0,-0.046119466,0.0014845718,-0.046968594,0.015505465,0.0033912824,0.0269893,-0.05817546,0.037671886,0.03277282,-0.02515012,0.0028975392,-0.034213573,-0.026258979,0.03088415,-0.032936703,0.068549484,-0.052408352,0.027488222,0.02373675,-0.06821386,0.022199592,0.05278168,0.024064047,0.0173483,0.012534637,0.04838875,0.03108495,0.058826238,-0.025158048,-0.06700366,0.030153269,-0.02215674,-0.038217448,0.006936794,-0.01701922,0.061547022,-0.14592667,-0.011435325,0.0029229342,0.01918007,0.07796591,-0.046862353,-0.09096691,0.028902048,-0.10822411,-0.08145182,-0.08846246,0.03241343,0.040870883,-0.00827793,-0.07001259,-0.030566305,-0.07698223,0.017002692,0.0019759985,-0.012830874,0.033047136,-0.03797878,-0.041719798,-0.0066159186,0.07915363,0.052526295,0.005352583,0.051778037,-0.024655629,0.021989949,0.016468968,-0.059522867,-0.012727337,-0.06777037,-0.043448873,-0.09202279,-0.05837509,0.010459379,-0.01901599,-0.028627645,-0.029505325,-0.0011944531,0.018446587,-0.018372707,0.07805107,0.079659194,-0.018129801,0.061100163,0.040280346,0.017541857,0.05043624,0.006576675,0.02415327,-0.07377322,0.016761668,0.038807083,-0.051912356,-0.079517305,-0.049899515,0.04168269,-0.022761337,0.047610007,-0.07110011,-0.0028513714,0.061258253,0.03662064,-0.06572823,-0.07498027,-0.060005832,-0.007460187,-0.033168323,0.0051572076,0.08316308,-0.02607356,-0.005552966,-0.06460545,0.070299186,-0.017267773,0.01930859,0.11602505,-0.030908499,0.00051676115,0.022592453,-0.04885699,-0.0066873245,-0.090956524,0.009094058,0.025864452,-0.015104185,0.04277789,-0.06525598,4.7920284e-33,0.09202311,0.05742788,0.0063291187,0.0042836517,-0.010425672,-0.037930515,-0.062310748,0.0672273,-0.052058794,-0.011794855,-0.06667747,-0.03763804,-0.018909242,0.016613832,0.03303528,-0.023150895,-0.05585558,0.050993264,0.03921152,0.016541375,-0.029815072,0.021837773,-0.060472,0.050648987,-0.031702563,0.13604298,0.022492947,-0.0054605813,0.04250878,-0.0324845,0.056713026,-0.048559856,-0.08115307,-0.006462278,-0.042215314,-0.024530513,-0.022748653,0.0029393097,-0.034770366,0.0094699655,-0.027901068,0.032061912,0.063891955,-0.031175304,0.03327625,-0.067201585,-0.07395425,0.14554662,0.05782802,0.07763543,0.06743111,-0.011451377,0.1480926,0.08919171,-0.055368006,0.03611696,-0.04343613,0.016756665,0.035493847,0.009502818,0.1050627,-0.010543918,0.018471109,0.009499682,0.046605393,0.02394681,-0.012668757,-0.022848982,0.034274433,0.100149065,-0.039972387,0.050140917,0.000863486,0.07141912,0.012875754,-0.040149134,0.010665343,0.020965923,0.023041518,0.0055482103,-0.01993727,-0.011478773,0.037312746,0.012557108,-0.02431104,-0.03688014,-0.00081445544,0.019394478,-0.02260039,0.032073323,0.02431287,-0.037324645,-0.09076532,0.026455365,0.0082871355,-3.4711176e-33,0.10497839,-0.13969366,0.01062889,-0.077874474,-0.018532028,0.025435025,-0.0051712384,0.071360126,-0.008401725,0.049622227,0.09133953,0.015703034,0.09615457,-0.06482707,0.10448648,-0.07103524,0.02980972,0.079867065,-0.041291352,0.024484277,0.014167052,0.07716109,-0.04997979,-0.018690936,0.0448005,0.063138604,0.02094106,-0.008535182,-0.020504013,0.0014861717,0.01731462,0.0892178,-0.071932726,-0.04054689,-0.0641529,0.07648334,0.00042928717,0.00076486805,-0.046102107,0.058629442,-0.036490135,0.10500548,0.024264855,0.11379134,0.042480163,0.02263167,-0.093109794,-0.044676084,0.005981139,-0.07395208,0.01776636,0.05720055,-0.0046268417,-0.003069451,0.010704465,0.040040515,-0.011190947,-0.047177132,0.013663863,-0.08185201,-0.036228947,0.005046286,0.034172274,-0.011701135,-0.048837166,0.09062326,-0.02612008,0.054503858,0.0016625269,-0.028959708,0.01841389,-0.015528853,-0.007298385,0.0430283,-0.026524123,-0.004058898,0.018715285,0.0027908268,0.045840815,-0.02627969,-0.000120146724,-0.03820985,-0.011073563,-0.094938435,-0.057800017,-0.07563728,0.024281973,0.12116078,0.0119351465,0.038988862,-0.020994108,0.020983852,-0.06772485,0.07480081,0.05674341,-3.9998035e-08,0.0064702854,-0.058430642,0.04999788,-0.018206403,-0.024733137,0.045115255,0.08183839,-0.04198216,0.018386396,-0.07594197,0.016570454,0.03558927,-0.036942557,0.0013728476,0.05576237,0.033745207,0.05256094,0.07239655,-0.04306124,-0.007979012,-0.048331324,0.009146979,-0.056033157,-0.0065637464,0.03360644,-0.045963973,0.028448788,-0.023804156,0.015936578,0.023081508,-0.027689496,0.041499253,-0.015148316,-0.04255702,-0.0039920285,0.038058285,-0.018855363,-0.009876908,-0.012099888,-0.048924778,-0.03371722,-0.066837534,-0.0912012,-0.034901015,0.0011547544,-0.024066716,0.02003688,-0.045067895,0.020226851,0.010228548,-0.018487545,-0.021084765,-0.0009421745,-0.096317954,-0.15904869,-0.0014824307,0.056903128,-0.026001533,-0.09168917,-0.10907109,0.030162511,0.014040825,0.23920271,0.034397922 +1.17.3.4,"Even though oxygen is consumed, molecular oxygen is not incorporated into the product. Catalysis starts by incorporation of an oxygen atom from a water molecule into the substrate. The naphthalene-1,2,4,8-tetrol intermediate is then oxidized by molecular oxygen, which is reduced to water. Also acts on 1,4-naphthoquinone, naphthazarin and 2-chloro-1,4-naphthoquinone.",384,0.99999994,0.026708646,0.02184803,-0.02455977,0.060359936,0.070485435,-0.008764789,0.017949343,-0.041462503,0.07333394,-0.039350037,-0.017083956,0.014250792,-0.044870596,0.046041436,-0.027540436,0.03745898,-0.10264646,0.015189895,-0.036131643,-0.086901665,0.048751768,-0.008649566,0.035630744,-0.01878306,0.03219356,0.035828628,0.046256945,0.0011280233,0.028418982,-0.017982876,0.031387776,-0.033815257,-0.0020932422,-0.063781284,-0.02352351,0.039759982,-0.015533358,-0.0122775035,-0.023473002,0.061149094,-0.046879046,-0.060714006,-0.11950027,0.019678036,-0.053119272,-0.070118204,-0.021578385,0.00012037929,-0.028845651,0.00026286923,-0.080171324,0.016630955,-0.12065209,0.05298157,-0.024027895,-0.027402673,-0.021925382,0.039187327,-0.012797054,-0.06403906,0.05898631,-0.0029924659,-0.018777812,0.023845088,-0.027923187,-0.050192382,0.056087714,-0.04210927,-0.04866069,0.014817402,-0.036336288,-0.027482398,0.03778501,-0.031903945,-0.033681884,-0.0051899673,0.06779594,-0.058570202,0.0899385,0.021292102,0.036654063,-0.0041322727,0.007502701,0.06926166,0.01789753,0.048035383,-0.050321978,-0.037732128,0.034262788,-0.0083490135,-0.058010343,0.011477921,-0.015615408,-0.06147167,-0.003855554,-0.02506785,0.0997517,0.038795177,0.07241354,0.012565461,-0.037011832,0.051667407,-0.12670286,-0.12521169,-0.032324612,0.02087902,-0.03279539,0.064676434,0.07124219,0.008573415,-0.0015071753,-0.035829,0.06830849,0.014063575,-0.04623652,0.09605632,-0.009523449,-0.052767076,-0.07732354,0.059907984,-0.024631957,-0.03185062,0.039860964,0.032706905,-0.0661819,0.012070482,-0.04901678,1.7161652e-33,0.0346728,-0.032950506,-0.005917079,0.03671481,-0.04478114,-0.055430304,-0.07471962,0.0001147234,-0.082094476,0.0012001515,-0.10254275,-0.0077316365,-0.00036887912,0.023614747,-0.0009152358,-0.049548265,0.017307257,-0.0085714655,0.019894881,0.03487686,-0.05121327,0.06062446,-0.009043751,0.012278736,0.02081525,0.056317035,-0.0172428,-0.007615374,-0.07201524,-0.009427384,0.050969202,-0.048899148,-0.12017171,-0.013278356,0.03243326,-0.019073546,-0.04350235,0.022657348,0.028609464,0.00018107757,-0.055777624,0.05240879,-0.026849637,-0.08105629,0.0065126214,-0.036460254,-0.015607357,0.13157058,0.11916541,0.069382295,0.020639032,-0.028385483,0.08044835,0.0029497442,-0.073668584,-0.044545572,-0.018875018,-0.11583494,0.072490394,0.06838468,-0.032337148,0.013861428,-0.020992165,-0.004030385,-0.016265687,-0.01043854,0.0049522105,0.045647822,0.017537259,0.022027455,-0.01934354,0.093046166,0.0771873,0.01614164,0.06238072,-0.0117043145,0.021559136,-0.021025578,0.046910025,0.05845289,0.077212214,-0.025705736,0.030448692,-0.06023334,-0.073501356,-0.0026450157,-0.034168262,-0.0069954237,-0.007167965,0.11932261,-0.016055807,-0.12563296,-0.008228015,-0.16147038,0.068082765,-3.7401534e-33,0.0982161,-0.053281404,-0.05213659,-0.15333587,-0.049544483,0.04617197,-0.0051785186,-0.0859738,0.0010118479,0.04320085,0.013590038,0.035568237,0.056525692,0.028689085,-0.018433426,-0.053439423,-0.0412552,0.057937123,0.08950513,-0.018830216,0.053520784,-0.010035912,-0.043627985,0.05990511,0.037748206,0.014384503,-0.04733866,0.038287222,0.076651245,0.026453733,0.040128835,-0.07512788,0.032749463,0.029716335,0.01881076,0.07644403,-0.047975924,0.026396604,-0.012453694,0.013749807,0.03789039,-0.03831999,-0.018215025,0.058346193,0.02202127,0.0067563755,-0.04063203,-0.032622136,-0.0373533,-0.074181415,0.0536455,0.061112087,-0.078622825,-0.047391158,0.037169017,0.09702547,0.048718173,-0.06834518,-0.016753597,-0.01700734,0.0450964,-0.047623158,0.050810724,0.0066217007,-0.04798714,0.023760857,0.024084989,0.04806107,0.08895348,-0.084004164,0.011563271,0.010316897,0.028411103,-0.036956202,-0.007308576,-0.038101874,0.017190732,-0.0008198081,-0.013412541,-0.0316534,0.020876363,0.052644514,-0.0063555315,-0.13857226,-0.005527075,-0.0104022315,0.018556492,-0.012313582,-0.026259955,0.031549633,0.00030806224,0.07739527,-0.015274401,0.063279405,0.0106862,-4.2760416e-08,-0.011607037,-0.028006706,0.1269484,0.031577367,-0.035427846,0.059907533,0.12219227,-4.3789078e-05,-0.015022551,-0.014874344,0.03511354,0.09103176,0.05200474,-0.070519306,0.08454572,-0.008754862,-0.013363834,-0.048934348,-0.039670464,-0.0008433354,-0.040288657,0.020442747,-0.095677614,0.034119464,0.0052962704,-0.05017556,-0.007188305,0.0156119205,0.0046885973,-0.03884766,0.05635713,0.064358644,-0.03272197,-0.009686451,-0.0343076,-0.08022437,0.026756782,0.006628585,-0.044293236,-0.032214604,-0.10433795,0.039178677,-0.045970086,0.030767381,0.020398129,0.03525237,-0.019929612,-0.102565795,0.011446639,0.044573314,0.08134388,0.0021269836,-0.011375971,-0.038884584,-0.084809124,0.039420098,-0.034330573,0.006204626,0.006905283,-0.05629228,-0.0013926522,0.0026861485,0.20270878,-0.015959434 +1.17.98.2,"The enzyme, found in green sulfur bacteria (Chlorobiaceae), is a radical S-adenosyl-L-methionine (AdoMet) enzyme and contains a [4Fe-4S] cluster. It catalyses two consecutive hydroxylation reactions of the C-7 methyl group of bacteriochlorophyllide c to form a geminal diol intermediate that spontaneously dehydrates to produce the formyl group of bacteriochlorophyllide e.",384,1.0,-0.08901055,-0.027367907,-0.080297105,0.014530003,0.04588008,0.09236924,-0.07590587,0.054292977,0.02632526,0.0054093855,0.016651953,-0.068657316,-0.033330485,0.039365917,-0.0038839688,0.099473044,-0.12776999,0.03108327,-0.010342374,-0.10409689,0.007079355,0.059145395,-0.06727462,-0.03119546,0.032775722,0.06179129,0.050505985,-0.015352765,-0.03166934,-0.085815266,0.0010256767,0.010983477,0.054268483,-0.031050747,0.0561225,0.09428736,0.012460005,-0.11127984,0.0808494,-0.011171511,-0.03801468,0.081554875,-0.024146352,-0.00764949,-0.041354116,0.004667852,0.013357958,0.092286296,0.043733142,-0.11751643,-0.027353149,-0.018861849,-0.053047106,0.064423755,0.020549506,-0.04031526,0.005227709,-0.08575871,0.03273662,-0.017335948,0.06132976,0.018016083,0.017737087,0.00039502783,-0.043910097,-0.03957481,0.01593975,-0.056089956,0.0892431,-0.101966,-0.07115072,-0.038823977,0.0012061385,0.06934079,-0.047277693,-0.011429373,0.04604708,-0.0139384065,0.03461404,-0.01757112,0.032167934,-0.0077821882,0.006716625,0.08690962,0.061336733,-0.023064155,-0.0064344355,-0.022697493,0.07797419,-0.016967352,0.007928928,-0.022471713,-0.052214198,-0.0788509,-0.11890645,0.04210276,-0.013491275,-0.005242433,0.020214872,0.005713739,0.006083494,0.021538194,-0.0515364,-0.08003689,-0.014347277,-0.042087972,0.032994032,0.14430158,0.01568726,0.0019125569,0.003857737,-0.0071855355,0.008514404,-0.018066848,-0.034833223,0.062461093,0.08545458,-0.06083218,-0.07079107,0.006265924,0.009697244,-0.019290945,0.023771862,0.017599437,-0.048470084,0.023699712,-0.17941035,4.6816476e-33,0.1239882,0.04241856,0.07409306,-0.04669091,0.025955882,-0.039045643,-0.098494425,0.06903785,-0.021968892,-0.06600912,-0.05661327,-0.086599275,0.033160817,-0.055947952,-0.066627115,-0.02083756,-0.059500422,0.03697255,0.023229301,-0.010320914,-0.046329547,-0.0008424112,-0.040726036,0.02720306,0.027392566,0.072345264,0.029970245,0.0263503,0.1338652,0.0026306824,0.0028642684,-0.06030461,-0.0539344,0.025575396,0.057456743,-0.0064273244,-0.0783488,-0.04153124,0.052915,0.095096774,-0.020658022,0.016365394,0.040580958,-0.056206252,0.057712235,-0.021323131,-0.054553002,0.064111196,0.048457224,0.08239249,-0.005468429,-0.00943727,0.09976267,0.008340984,-0.060773972,0.03645759,0.032385606,-0.01817115,0.03806726,0.042569544,0.04017489,0.080083966,-0.07947921,0.012876825,0.0031731331,-0.041801795,-0.03224287,-0.00055432896,0.034558665,0.068574905,-0.074532256,-0.025122605,0.035665344,0.038066663,0.06489499,-0.07065649,0.019155236,-0.011735261,0.038412794,-0.009237106,-0.020536054,-0.048291698,0.02423474,-0.05660661,-0.05531461,-0.009047091,-0.06569857,-0.054127645,-0.042408478,0.007567785,-0.03135978,-0.0507337,-0.06511416,0.033562943,-0.030922795,-5.2857793e-33,0.05384993,-0.07425081,0.039115217,-0.07011927,-0.0036854986,0.008421601,-0.013156952,-0.01692619,0.010838042,0.040544268,0.09540772,0.034790184,0.009368754,-0.024314968,0.061748397,0.028625134,0.114122465,0.052106414,-0.031787433,0.03525052,0.04825889,0.044667635,0.04206989,-0.01509327,0.0356593,-0.008892962,0.061851367,0.016420003,0.09753308,0.027395077,0.012842408,-0.012357937,-0.03004929,-0.028358996,-0.024926135,0.020030595,-0.05901259,0.0049776174,0.045969006,0.026901571,-0.0055654002,0.004004211,0.0024420274,0.11380543,0.015192886,0.022173988,-0.036869295,0.042538144,0.014418771,-0.025633642,0.03688339,-0.040717695,-0.01805052,-0.0016096815,-0.04119499,0.042632364,-0.0052620084,0.028427439,-0.049355384,-0.023919776,-0.028026843,-0.10332997,0.02002574,-0.010452073,0.033023577,0.037897367,-0.044859838,0.039031938,0.02798768,-0.061568882,-0.0028050102,-0.006292546,-0.033697926,0.013826135,-0.07595809,-0.03382322,-0.0529203,-0.060750898,-0.016137997,0.023631936,-0.012709073,0.030582938,-0.0032667913,-0.08532775,0.012036059,-0.092592046,-0.012357048,0.11223731,0.0075318897,0.072606154,-0.057982307,0.050236173,0.018604567,0.0738304,0.03869863,-4.4426418e-08,-0.019052655,-0.09457579,0.048246704,0.019870732,0.012917787,0.05084687,-0.018881653,-0.04184515,0.037676986,-0.009934215,-0.02325951,0.111654535,-0.024167918,0.0030251662,0.020921275,0.045934312,-0.054503556,-0.048892066,-0.01288208,0.025109492,-0.018156564,-0.047533363,-0.06682136,0.08650964,0.015106843,-0.03329853,0.011819673,-0.039865192,-0.019116314,-0.03626441,0.046720434,0.056923714,-0.052172627,-0.024527801,-0.06669711,-0.027402917,-0.05850855,-0.02827011,-0.03538233,0.032668594,0.078989044,0.039343074,-0.104253955,0.070414916,-0.009779383,0.024392737,-0.05778851,0.062858924,-0.042783365,0.017795926,0.06944786,0.008901726,-0.019306898,-0.040874638,-0.100502305,0.010350483,0.025323346,-0.0673932,-0.01257981,-0.008399927,0.024935603,-0.040271997,0.17678706,0.052777264 +1.19.1.1,"A flavoprotein (FAD). This activity occurs in some prokaryotes and algae that possess flavodoxin, and provides low-potential electrons for a variety of reactions such as nitrogen fixation, sulfur assimilation and amino acid biosynthesis. In photosynthetic organisms it is involved in the photosynthetic electron transport chain. The enzyme also catalyses EC 1.18.1.2, ferredoxin---NADP+ reductase.",384,1.0,-0.104993746,-0.030193096,-0.12227301,0.027225753,0.12002547,0.024099413,0.0019917672,0.050571337,0.048293173,-0.032784205,0.017110378,0.012248975,-0.07880327,-0.018841406,-0.08242671,0.03566625,-0.06999974,-0.009780659,-0.05459901,0.008966406,-0.015303687,0.02028496,0.016266065,-0.064570285,0.02984603,-0.023883121,-0.027992876,-0.04815527,-0.026447864,-0.02714944,0.06401778,0.0656257,0.026598051,0.009709106,-0.030752389,0.11741641,0.020626374,-0.07542454,-0.011106269,0.00840458,0.042849004,-0.022259308,0.033455852,-0.035003994,0.034709867,0.0061190287,0.01446696,0.049178384,-0.022030557,-0.010014015,-0.012041494,-0.03958941,-0.10664264,0.06068843,0.018214628,0.014104356,0.013825703,-0.07031618,0.006518995,-0.022579124,0.013492867,-0.036918998,0.027373116,0.0066325436,0.06813738,-0.073280655,-0.048372913,-0.039543357,0.024018927,-0.073034406,0.00031676298,-0.029551707,-0.062498607,0.026786346,-0.007891094,0.03559755,-0.06641149,-0.029163584,0.04579612,0.002577618,0.06942833,0.00058261474,0.047821984,0.087771006,0.08569367,-0.039342128,-0.0049533327,0.000197268,-0.0600266,0.05326691,-0.02230311,-0.0055364924,-0.009473231,0.034273393,-0.10333949,0.08037544,0.066797845,-0.07945506,-0.025975771,-0.01579931,-0.021825183,0.038284387,0.02649545,-0.04512501,-0.027753256,-0.068066165,-0.04712639,0.11239442,-0.05760114,-0.05395285,-0.0024991368,-0.038950335,0.015969042,-0.06191873,0.005503361,0.044797454,-0.008060153,-0.07163316,-0.05258521,-0.003312772,-0.043231457,0.07879962,0.03883123,0.08940701,0.045008987,-0.012686846,-0.15535375,2.3272287e-33,0.114169896,-0.025511391,-0.01687709,-0.025014693,0.053042993,-0.018972714,-0.053186856,-0.04765018,0.04776231,-0.04044574,-0.07113474,-0.008056223,0.06398597,-0.049052536,0.02292789,-0.017607993,-0.06603596,-0.05478307,0.08669076,-0.050397743,0.048286103,0.01515984,-0.04282261,0.0528896,0.024239587,0.02701057,-0.062013593,0.009705365,-0.010170864,0.009840875,0.054310467,-0.04681811,-0.08162558,0.038806688,0.031437207,0.027561387,-0.068549536,-0.07957671,-0.08824115,0.05814119,-0.038561236,0.0015851106,-0.040534806,-0.019109966,0.07243131,-0.024986858,-0.05861064,0.08426466,0.030069588,0.10207803,0.041053012,-0.06282125,0.12789337,0.05439224,-0.08246369,0.02932821,-0.040407375,-0.032943115,-0.018935092,0.024033431,0.017895808,0.04239616,-0.019102192,0.07837658,-0.044595342,0.035833884,0.0050847726,-0.047487017,0.009798021,0.09192982,-0.0071040313,-0.017060751,0.09185789,-0.030274007,0.09908439,-0.010077675,-0.037855145,-0.061814558,-0.02733398,0.030393422,-0.00076398754,-0.044628754,-0.02061212,-0.052765038,-0.061051074,0.011815281,-0.055608284,-0.03861969,0.012942595,0.011278836,0.065575704,-0.050840914,-0.0007457891,-0.02102167,0.020707099,-2.101995e-33,0.057240512,-0.10323686,0.027704723,-0.015720753,0.021961903,0.033374798,0.021818431,-0.030026814,0.036522087,-0.010296263,0.0130899595,-0.01495534,-0.013650297,0.021554824,0.045725588,0.012442613,-0.04061824,0.033107996,0.06433346,0.037864283,-0.06876495,0.019894687,0.06340898,0.06948541,0.07967933,0.0009954659,-0.024826126,-0.047675494,0.045496617,0.018398134,-0.05298522,0.018808337,-0.06162001,-0.02704762,-0.058652967,0.048699513,-0.031205075,0.040184617,0.0013679884,0.023858929,0.024600212,-0.0141855255,0.0288044,0.06008586,0.039924026,0.035562236,-0.07710563,0.050491117,0.028284786,-0.039462447,0.015383021,0.06350855,0.0073787184,0.05644692,0.071488835,0.07919126,0.06852511,0.08065547,0.027428845,0.025835093,0.028694367,-0.13891034,0.021395275,0.0070230803,0.07138246,0.08722181,-0.0005643513,0.097552925,-0.017666409,0.04808631,0.1413415,0.0075984695,0.030868923,0.05818013,0.016404836,-0.04284544,-0.018589163,0.06526305,0.006035885,0.011234762,0.017190091,0.03863512,0.009026946,-0.0024267763,-0.06648151,-0.14304757,-0.003224518,0.049903765,-0.01230049,-0.004193526,-0.048760545,0.042282287,0.008342569,-0.056225386,0.031433735,-3.5393942e-08,-0.025251346,-0.028027471,0.022368032,-0.015157443,0.11087736,0.029457081,0.004692834,-0.0023474828,0.018354025,-0.037099514,-0.031097652,0.14302866,0.05475744,-0.07389999,0.09459397,-0.012623293,0.011801181,-0.010121312,-0.033319686,0.0027683175,-0.057832427,0.017922476,-0.12712663,0.042474914,-0.04277039,-0.03564473,0.03407772,0.006031945,0.056746896,-0.050234266,0.010489279,0.042568136,0.054882027,-0.049256306,-0.13399328,0.04175894,0.0062007136,-0.10292127,-0.029499704,0.0017866548,-0.10132832,-0.00060393324,0.013626229,-0.04477301,-0.024146413,0.029404245,0.05819787,-0.016442489,-0.041605096,0.014313411,0.010710068,-0.029383687,0.0155825885,-0.031296678,-0.08797622,0.019050336,0.012878093,-0.08168229,-0.0005083663,-0.00954,-0.03889783,0.039829154,0.12688608,0.011841878 +1.21.98.3,"This radical AdoMet enzyme participates in the biosynthesis of chlorophyllide a in anaerobic bacteria, catalysing the formation of an isocyclic ring. Contains a [4Fe-4S] cluster and a cobalamin cofactor. The same transformation is achieved in aerobic organisms by the oxygen-dependent EC 1.14.13.81, magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase. Some facultative phototrophic bacteria, such as Rubrivivax gelatinosus, possess both enzymes.",384,1.0,-0.10688497,0.014269071,-0.14063786,0.026294876,0.062077418,0.015598946,-0.021660231,-0.0058671352,0.01822092,-0.038889732,0.027158555,-0.03196415,0.036621097,0.044596832,-0.015272472,0.027135773,-0.09002824,0.051890295,-0.058347467,-0.028938727,0.045722473,0.0068647256,-0.03922311,0.0010585309,0.0082271015,-0.013767899,0.01888775,-0.034278974,-0.057313822,-0.02956914,0.038362507,0.06546669,0.10152056,-0.111582495,0.060430653,0.118280195,0.008959172,-0.09083667,0.085501514,0.02353052,-0.015186905,0.051474694,0.016301017,-0.032142937,-0.0016126549,-0.014945755,0.086753845,0.014651711,0.059163757,-0.055281073,-0.06455097,-0.005095277,-0.07079043,-0.011399881,-0.03330895,-0.05302654,-0.04824577,-0.08889338,0.036271684,-0.036389608,0.06472928,-0.026494551,-0.02398865,0.037554596,-0.06340926,-0.04631986,0.02760772,-0.07599275,0.041277725,-0.07326538,-0.056561235,-0.031059764,-0.04901822,-0.0025544316,-0.10006084,0.053155877,0.06511249,-0.039461,0.00313074,-0.026396614,0.05906483,-0.016606621,0.010073554,0.05640563,0.06637347,-0.003931037,0.060863543,-0.008012658,-0.00029098755,0.061977986,-0.0028180487,0.06595293,0.049994063,-0.04254414,-0.0678437,0.02168589,0.0007277612,0.009927289,0.023806999,-0.04017596,0.025731442,0.045765176,-0.0068082726,-0.039280605,0.05503129,-0.060224835,0.025383815,0.13614742,0.07546346,0.038081773,0.04829672,0.041225422,-0.021872135,-0.06189428,0.005621712,0.121561214,0.033658415,-0.039409045,-0.09159798,0.01213161,0.02219249,-0.043859344,-0.006334675,0.01661368,-0.02960589,-0.02971484,-0.12748812,4.7131e-33,0.04706436,0.02416946,0.024097739,-0.007052979,-0.029205592,-0.03255546,-0.13631283,-0.039681163,0.012392696,-0.08690243,-0.05389382,-0.022713443,0.065326676,-0.00054883043,-0.03887582,-0.079542056,-0.031341933,0.0076273363,0.042478364,0.038563497,-0.01905577,0.060669445,-0.05792265,0.059524376,0.045984734,0.06477508,0.041771,-0.039555166,0.08192649,-0.008839188,0.0515611,-0.08532976,-0.09987759,0.019972302,0.09039996,0.018789753,-0.047780428,-0.018099787,-0.003907028,0.0229211,-0.08808012,-0.00017214175,-0.030631334,-0.027772041,0.1086133,-0.013310878,-0.07269201,0.077241465,0.034792855,0.07606138,0.008398603,0.001736693,0.09158321,0.031683974,-0.044134595,0.044654217,0.007337196,0.026242927,-0.003952475,0.029103136,0.04521512,0.043777693,-0.06932132,0.023831747,-0.018625977,0.01895038,0.003605122,-0.027877653,0.008453627,0.04861287,-0.071309626,-0.025550075,0.031075042,0.06682617,0.041943107,0.0011673148,0.00873627,-0.04828702,-0.024193468,0.025218816,-0.027417859,0.011180603,0.051938392,-0.09440352,-0.052713856,0.038233466,0.0010110912,0.042414013,-1.3973656e-06,-0.0121415695,0.09254252,-0.02099202,-0.040089246,0.03530812,-0.063757434,-4.442193e-33,0.10445319,-0.10013232,0.04341629,-0.10739482,-0.056256525,0.03729613,-0.0061353445,-0.07146798,-0.0722406,-0.033535484,0.054360397,-0.018471483,-0.07800738,-0.0336919,-0.0014133571,-0.0380182,0.05792208,0.07254072,-0.03212704,0.0144963125,-0.085177034,0.05275261,0.06569501,-0.033004917,0.01245026,0.03565041,0.033043534,0.04350934,0.058421433,0.04006337,-0.022959549,-0.028255656,-0.024909843,0.03397498,0.00565315,0.08197825,-0.021268161,-0.0042474708,0.016129468,0.028578937,-0.008926136,-0.029430332,0.0005275523,0.0731068,0.07160752,0.006808216,-0.07630587,0.051804032,-0.036970288,0.014030091,0.05499785,0.022522809,-0.062526815,0.000962928,0.058904503,-0.01380485,0.084848545,0.02153152,0.028279869,-0.0523605,0.0051220395,-0.07477564,0.08069564,0.044951215,0.03366766,0.1196114,0.042468235,0.101867095,-0.02881605,0.04616643,0.079337984,0.057359464,0.002368979,-0.0020496135,-0.013206004,0.03484817,-0.010499218,-0.021070257,-0.03477495,-0.040010277,-0.039478265,-0.0027683624,-0.0072387396,-0.04749386,-0.076756634,-0.08062347,0.0021534583,0.0070582433,0.026979784,-0.021480229,-0.005009044,-0.014367197,0.03670986,-0.0036121374,0.0801508,-3.9963197e-08,-0.022951528,-0.011342006,0.051113825,-0.039451085,0.04086874,0.05584104,0.0029056587,-0.06908091,0.08248741,0.0029874519,0.01840848,0.060583785,0.03639658,-0.044384904,0.0058104726,-0.020108912,-0.03172466,-0.008249304,0.015937442,0.03904857,-0.06275058,-0.012001758,-0.16695096,0.05523527,0.00035835287,-0.081492126,0.03885675,0.017051503,0.05143459,-0.009455837,0.027325058,0.0340198,-0.023144094,-0.06992245,-0.113142565,-0.05334604,-0.02333841,-0.03656679,-0.06704082,0.040187016,-0.06314833,-0.042178232,-0.088260345,0.0048313607,0.006018364,0.00889537,0.057204764,0.005993877,-0.047463316,0.013204901,0.02261481,-0.032200422,0.02104,-0.037318036,-0.13846801,0.022372268,0.0070652855,-0.027774652,-0.034316257,0.05263464,-0.04951155,-0.01654191,0.12555923,0.01652124 +2.1.1.329,"The enzyme, found in plants and cyanobacteria, catalyses the final step in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is specific for the quinol form of the substrate, and does not act on the quinone form [3].",384,1.0,-0.11570946,0.036705725,-0.07817569,-0.031011416,0.0387764,-0.034673914,-0.0023590946,0.023851387,-0.005821034,0.059672512,0.08482783,-0.035746638,-0.022745213,0.016049512,-0.03896632,0.106497556,-0.123579845,0.004318294,-0.013218727,0.014625309,0.0020628558,-0.05885825,-0.042448096,0.03019654,0.07904435,0.00985722,0.007666491,0.034674447,-0.049690392,0.028908007,-0.03403156,-0.0380561,0.04095029,-0.0028897359,0.040335603,0.10021213,-0.050689165,-0.10068489,0.021804353,0.0497922,-0.0029135286,-0.033398647,-0.05515402,0.014748777,0.023956267,0.03460085,0.04540195,0.07756648,-0.0005037422,-0.031683646,-0.07593268,-0.03450937,-0.053819086,0.056892905,0.014240095,0.05150638,-0.05669516,0.06195972,0.0043010493,0.084469154,0.037232842,-0.026158713,-0.065111384,0.0020090393,0.025311057,-0.03968235,-0.048346706,-0.030211985,0.06849484,-0.08991165,-0.012864503,-0.081750624,-0.014763299,-0.034640364,-0.019439718,0.039226186,-0.008781323,0.008225023,0.006580215,-0.015989805,0.021631286,-0.004752104,-0.017600121,0.051314645,0.046553705,-0.018636962,0.025343573,0.011030734,0.05512373,0.010775445,0.017342808,-0.019638544,-0.039648443,-0.09258937,-0.07639064,0.12207869,0.011483029,-0.025128948,0.032748483,0.0014520931,0.009779992,0.026535746,-0.017131874,-0.10052319,-0.07102443,0.012775403,-0.017444884,0.08306703,-0.041518614,-0.019526178,-0.04058242,0.004414767,-0.004775157,-0.0010669444,0.01808791,0.069412895,0.05747089,-0.058880888,-0.065376066,0.016094154,-0.029861338,-0.012328781,0.031955373,0.020491986,-0.05117077,-0.007995066,-0.024679525,8.718885e-34,0.06454307,0.06811958,0.029092923,-0.045323953,0.0082600145,-0.018224023,-0.06278978,0.06504701,-0.11117878,-0.13152854,-0.085832,-0.10575679,0.02978,-0.024476163,-0.056020863,0.04053438,-0.029799737,-0.04915941,0.050339915,0.08416152,0.018810233,-0.0006341862,-0.04103948,0.020914273,-0.04169841,0.09592186,-0.015687088,0.0007380175,-0.0012578171,-0.009903526,0.038869757,-0.055327535,-0.026014226,0.006712009,0.015149237,-0.023456125,-0.071999155,-0.04209905,-0.04121361,0.06630946,-0.071046114,0.03807667,0.022423664,0.046908043,0.014945119,0.039964624,-0.023572423,0.045834772,0.055048257,0.006050666,0.021432724,0.029276706,0.07585887,-0.0021119816,-0.0777194,0.05107967,0.04851244,-0.07218144,0.025057321,-0.030509563,-0.0049121394,0.04917095,0.00517956,0.051654298,-0.03922093,0.02745203,-0.078165576,0.018018564,-0.01230505,0.0857907,-0.042361837,-0.016200604,0.029540747,-0.05885172,0.0807378,0.003431115,-0.027984267,-0.05754652,-0.07552646,0.008446403,0.00044670526,-0.07365785,0.01609043,-0.024283435,-0.06613503,-0.05207538,-0.00863054,-0.05047087,0.0121288905,0.01987978,0.01836871,-0.015606425,-0.02028024,-0.03769161,0.017138477,-1.3846361e-33,0.10982751,-0.107765675,0.023655437,-0.057239804,-0.019968972,0.09045634,-0.048489843,-0.06369057,0.028711155,0.05709407,0.048171766,-0.025753615,0.017191498,0.020187512,0.021486266,0.030051596,-0.015086214,0.10198132,0.02994179,0.0010965449,-0.022024546,0.04703319,0.01399794,0.0041646212,0.055136397,0.034304563,-0.036592286,0.065678984,0.09111138,0.059083592,-0.072877735,-0.05076357,0.018155977,-0.0076668235,0.045360915,0.110055946,-0.04647934,-0.026318656,0.04974138,0.08894946,0.020276763,-0.045258977,0.02163979,0.038692445,-0.012857353,0.030358491,-0.054120995,0.10457854,-0.045484617,-0.054349612,0.08534476,0.1106572,-0.04025947,0.036923964,0.056310225,0.11313263,-0.017798958,0.034980364,0.014042776,-0.03810111,-0.026041394,-0.18894686,0.008581542,-0.009714668,0.0062128725,0.057169806,-0.013659447,0.13065456,-0.031870678,0.017827962,0.071002096,0.03436447,0.05732976,0.04219152,-0.042855397,-0.0015453827,-0.04225604,-0.03677712,-0.023371777,0.010013388,0.04768076,-0.03894353,0.011366275,-0.04629955,-0.033073936,-0.08426063,0.019782687,0.07504,-0.05092003,-0.01711676,-0.023093542,0.04435025,-0.03454781,0.07100514,0.082081296,-3.4082127e-08,0.0074032303,-0.06827288,0.04643398,-0.0314444,0.07038313,0.0006485854,0.017606322,0.05873259,0.06295262,0.0064928015,0.042905208,0.04777996,0.04848981,-0.010692697,0.046303306,0.044635054,0.016917255,-0.031973887,-0.021793421,0.075675055,-0.057746653,-0.032423325,-0.13449754,-0.053481944,-0.0510198,-0.06385646,0.0081811985,0.04295647,-0.072162956,-0.031342342,0.05404264,0.016125886,0.022679625,0.0021538816,-0.106312774,0.06790229,-0.06983372,-0.0495321,-0.033164855,-0.051119037,-0.047394466,-0.03338427,-0.061062895,0.05090293,-0.030640839,0.022617351,0.0759959,-0.007276724,-0.016590029,0.04960289,-0.005679796,0.019084034,0.03688596,-0.079935595,-0.06689203,0.024819113,0.028324107,-0.06467749,-0.03516289,-0.03744793,-0.008895357,0.0150788855,0.17741574,0.018954106 +2.1.1.330,"The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.",384,0.99999994,-0.012249111,0.01880922,-0.07119016,0.023771247,0.027877402,0.12931362,-0.054166507,-0.0009702234,0.061735444,0.017887011,0.020085426,-0.04247516,-0.06040135,-0.008990172,-0.085900486,0.06371079,-0.07674411,0.0138120465,-0.021185378,0.0021042088,0.0017608954,0.05315498,0.03172924,0.030318005,0.037503116,-0.054987438,-0.085525475,-0.0011884307,0.012902997,-0.0507211,-0.006631137,0.071572386,0.022127755,-0.026982054,0.06903,0.07708543,-0.030878328,-0.0370162,-0.0090312855,0.031912424,0.0463251,-0.049360003,-0.08033283,0.019761853,-0.038021635,-0.045164637,-0.055667143,-0.07253206,0.033229038,0.046084348,-0.04876543,-0.078831755,-0.045605373,-0.006914129,0.02726238,-0.041466467,0.053454634,0.061640102,0.03157652,-0.012601081,0.08997956,0.008375367,0.013180162,0.070643514,-0.01715647,-0.064652815,-0.02562768,-0.03444281,0.008963257,-0.027979871,0.0130340895,-0.09836179,0.061914645,0.03881283,-0.02134274,-0.00242275,-0.011670904,0.015726946,-0.03219273,0.0063516023,0.099909,0.09065731,0.06713458,0.14578104,-0.0069557643,0.030898038,0.019628821,0.010817922,0.00068428443,-0.04509085,0.03212795,-0.022802636,-0.040833246,-0.0217566,-0.039121505,0.045692734,0.05024829,-0.050026506,-0.010671624,-0.039546542,0.047846694,0.012800969,-0.1250543,-0.13031897,0.041378975,0.0034366979,-0.079077646,-0.016828122,0.012443926,-0.009249429,0.0059083086,-0.033453587,-0.037471306,0.026949529,-0.013387649,0.07175277,0.035376985,-0.040105335,-0.028380793,0.039615292,-0.016332377,-0.05376644,0.03885991,0.07521126,-0.056934144,-0.021989482,-0.07509597,1.9573006e-33,0.09006086,0.043843422,-0.025854085,-0.059053045,0.07143854,-0.08922413,-0.048955444,-0.07532324,-0.08563709,-0.006564477,-0.10995776,-0.009368,-0.009144643,0.020955013,0.01108631,0.0033396338,-0.07599434,-0.011700088,0.044502974,-0.057016604,0.040484976,-0.02489291,-0.110298604,0.019974694,0.003419746,0.117600754,0.037443545,-0.020049557,0.04086802,-0.037978932,-0.0035484843,-0.058957774,-0.066035084,0.019043958,0.006147443,-0.024433551,-0.028395299,-0.040652104,-0.05468062,0.052214537,0.010638251,0.007708873,0.01634299,-0.05612555,0.09610017,-0.003513858,-0.084693186,0.018882234,0.059025656,0.03997099,0.02045618,-0.009850082,0.10217663,0.025597328,-0.061177775,0.026207803,-0.036285024,-0.013943276,-0.016516207,0.034134626,-0.011696132,-0.06074652,-0.027445352,0.02950248,0.036837697,0.05204816,-0.041226007,-0.07967854,-0.0068608243,0.0131582115,-0.09229252,-0.04572663,0.055935256,0.06503427,0.038498253,-0.0065454305,-0.034934144,0.05229265,-0.052200437,0.04262001,0.0170564,-0.029122856,-0.009261484,0.0147187,-0.042269483,-0.060610447,0.0056767124,0.025887715,-0.037850108,0.0153828375,0.010869665,-0.0530672,-0.058055945,0.019533344,-0.048452254,-4.2920946e-33,0.067661494,-0.04968999,0.08033887,-0.06737974,-0.016224109,0.09184972,-0.04695682,0.009151135,0.0792131,0.073886305,0.042202894,-0.008001409,0.08192674,0.023701958,-0.044605855,0.005456463,0.014403848,0.029429628,-0.061364587,0.008631591,-0.087623976,0.00082806294,-0.054054014,0.030780243,0.02748506,0.014213452,0.035687763,-0.012541029,-0.0268624,0.04654965,-0.0015216921,0.02724478,-0.09154635,0.04727973,-0.001479641,0.020840483,-0.08313125,-0.004795183,0.029045599,0.021322966,0.041026562,-0.01353703,0.022636693,0.02396467,0.08897527,0.018666264,-0.11146662,0.060902413,0.014271131,-0.0315165,-0.0045178086,0.080724105,0.0077119553,0.05908204,0.026895242,0.035191517,-0.011339945,-0.025310114,0.00016145465,-0.0206711,0.029839639,-0.026574427,0.027786754,0.07042338,-0.026300082,0.12057636,-0.041372053,0.0003727645,-0.0054822573,-0.011589341,0.07271902,0.023240583,0.054112583,0.0853632,-0.046583276,-0.034894742,-0.01169614,-0.08297717,0.014487199,0.013899434,0.04863538,0.043574933,0.03167379,-0.05844402,-0.009294486,-0.024508515,0.04389789,0.1233464,0.010844447,-0.0371112,0.04905957,0.009161161,-0.11497433,-0.008890936,0.07502227,-3.6363872e-08,0.059484832,-0.012626253,0.049555864,-0.07454959,-0.0322124,-0.022186968,0.049949538,0.013771678,0.04984482,-0.03392771,-0.030072639,0.048265345,-0.052067664,-0.0032182427,0.008153792,0.01744252,0.02600493,0.05962604,0.0034069712,0.00371808,-0.06140346,-0.008268734,-0.044701945,0.005035617,-0.014546647,-0.041626927,0.024763964,0.022779021,0.02993644,-0.05247111,0.0037514854,0.059365157,-0.060556732,-0.028776627,-0.12725462,0.07965996,0.05210197,-0.08563418,0.0019398318,0.0054714954,0.0027683247,-0.035036664,-0.030937472,-0.044138264,-0.04185692,-0.0010361533,0.07887737,-0.01692615,0.026678624,0.056616206,0.016681172,-0.01560585,-0.0063571944,-0.12692262,-0.11338566,0.031910345,0.007123309,-0.035838667,-0.045134343,-0.06675742,-0.056339897,-0.07383747,0.27053073,-0.0045948457 +2.1.1.331,"This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green flimentous bacteria (Chloroflexaceae), is a radical S-adenosyl-L-methionine (AdoMet) enzyme and contains a [4Fe-4S] cluster. It adds a methyl group at the C-121 position of bacteriochlorophylls of the c, d and e types. This methylation plays a role in fine-tuning the structural arrangement of the bacteriochlorophyll aggregates in chlorosomes and therefore directly influences the chlorosomes absorption properties.",384,1.0,-0.026592985,-0.027125519,-0.12701058,-0.03472869,0.08856775,0.084754944,-0.06624388,0.053670436,0.07257439,-0.041182123,0.0031215306,-0.045023434,-0.02080336,0.07134851,0.020165145,0.08452771,-0.12002324,0.050649654,-0.018617323,-0.06281305,0.013188445,0.053177044,-0.052550063,-0.06338526,-0.024684157,0.045318786,-0.010326921,-0.04096302,-0.03412643,-0.07529705,-0.01791034,0.079986796,0.09700659,-0.03662273,0.06310467,0.0706951,0.02867831,-0.083992176,0.04733394,0.014713483,-0.030631047,0.10033895,-0.008149902,0.0155574605,-0.076904975,0.0007116544,0.038131896,0.056044325,0.06080552,-0.102365695,-0.02329226,-0.01754514,-0.080071084,0.0752141,-0.03146852,0.024258496,-0.003343135,-0.05138796,0.04553049,-0.049170513,0.07362727,-0.023630382,0.04001003,0.00705686,0.009654812,-0.04169394,0.05226276,-0.062249884,0.076362826,-0.11410736,-0.038743783,-0.0052603907,-0.020745644,0.084496535,-0.027295012,0.033479862,0.061701793,-0.018456869,0.022795942,-0.01223507,-0.0050197546,-0.011951854,0.014495078,0.078140415,0.08187107,-0.036366608,-0.034604795,-0.0046362546,0.065833405,0.014301653,0.027775746,-0.019145647,-0.07222019,-0.043133207,-0.13473177,0.017891552,-0.01745984,-0.009763804,-0.0038642616,-0.02460358,0.009238987,0.029626071,-0.0504837,-0.042218167,-0.0045668175,-0.05895015,0.038977213,0.15442193,-0.0067187403,-0.024562078,0.023770526,0.0416767,0.02244978,-0.012500332,-0.031590626,0.033917688,0.0455288,-0.04554892,-0.06883867,0.020398743,-0.030352134,0.0061060237,0.037983447,0.02129585,-0.0063592754,0.035136018,-0.18610847,2.6529144e-33,0.07536733,0.026658874,0.08025699,-0.05301162,-0.0076359203,-0.09590986,-0.06381012,0.02816431,-0.01994801,-0.068688385,-0.057143915,-0.054467592,0.04250342,-0.024229145,-0.04827604,-0.015100806,-0.061093993,0.010805403,0.008522065,-0.02395127,-0.056195628,0.011648013,-0.050251633,0.049480397,0.04196296,0.021213626,-0.0008776395,0.04277182,0.087011404,0.017469995,0.009058975,-0.062452838,-0.09997171,0.037318405,0.07994104,0.052125983,-0.06330699,-0.017572382,0.030398933,0.072063655,-0.057642803,-0.010908769,0.07094881,-0.00067339675,0.032800816,-0.007898787,-0.09148152,0.057405464,0.029459368,0.101301745,-0.037723076,-0.025084546,0.09522658,0.021143617,-0.0858806,0.014351176,0.052970625,-0.030059017,-0.03559111,0.036102656,0.011787364,0.024893044,-0.04755518,0.043398876,0.033831093,-0.016167965,-0.025401976,-0.060315754,0.024691736,0.064477175,-0.060474385,-0.0018131556,0.089006044,0.048630722,0.039198197,-0.048681367,0.039813817,-0.06966863,0.04862585,0.019388564,0.015141268,-0.035073377,0.044333626,-0.105559245,-0.12709028,-0.027017577,-0.01449754,-0.043451868,0.009335388,-0.01644052,-0.012879366,-0.048842452,0.01601888,0.027344665,-0.06388078,-3.3691942e-33,0.05526539,-0.06796754,0.079044215,-0.07266432,-0.011167976,0.021475168,-0.02846572,0.002352142,-0.00993519,0.015990889,0.12072537,0.054204803,-0.036430646,0.011790307,0.053921383,0.05478067,0.081942335,0.012809443,0.018920463,0.038275834,-0.014273432,0.04813766,0.06817332,0.025908634,0.014917633,-0.012633659,0.008058453,-0.047441624,0.056224413,0.00729325,-0.027089914,-0.023934882,-0.021997726,0.014065332,-0.005240325,-0.0076496284,-0.01003701,-0.023116862,-0.0037760069,0.07199168,-0.051942594,0.03724316,-0.020013966,0.048019625,-0.0096403565,0.061040536,-0.020930463,0.015090062,-0.040668476,-0.044750433,0.027090084,0.006149073,0.027408317,0.0075733745,-0.0046086092,0.039529607,0.011827563,0.03516206,-0.058270615,-0.022312403,-0.0118484935,-0.11316708,-0.027206227,-0.015264245,0.05015123,0.038247917,-0.032414526,0.034006875,-0.0044603394,-0.0034338043,-0.036439903,-0.04540579,0.028842406,0.040840648,-0.104691215,-0.060242485,-0.03482774,-0.042697653,-0.037157767,0.0012258597,-0.032736506,0.037974723,0.004571547,-0.051470987,0.0123602,-0.06610814,-0.008764501,0.09356083,0.0036919147,0.0606491,-0.06791523,0.01620113,0.07483212,0.057990126,0.054062318,-4.4270454e-08,-0.0060083484,-0.106259406,0.011756805,0.022269238,0.013441636,0.063439965,-0.04614391,-0.044306263,0.050635535,0.03331025,-0.06976656,0.093741104,-0.021180319,-0.009687551,-0.0084969895,0.026295327,-0.078250915,-0.043214243,0.008126498,0.020887852,-0.06380486,0.0028044696,-0.10883897,0.041909557,0.05633728,0.028733823,0.029368158,0.011472432,-0.004997355,0.030260654,0.025800051,0.054759145,-0.04514467,-0.0056363274,-0.109682314,-0.028712694,-0.03874246,-0.04232445,-0.085459284,0.0836296,0.102134205,0.05150163,-0.09192044,0.0765964,0.017747957,0.0014177916,0.0011837044,0.102904834,-0.023087712,0.0024719688,0.025069287,0.0063769636,-0.03774751,-0.05363123,-0.1065732,0.010889084,-4.63303e-05,-0.06315109,-0.028723903,0.010037815,0.0005957635,-0.023912605,0.12022128,-0.0012395246 +2.1.1.332,"This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green flimentous bacteria (Chloroflexaceae), is a radical S-adenosyl-L-methionine (AdoMet) enzyme and contains a [4Fe-4S] cluster. It adds one or two methyl groups at the C-82 position of bacteriochlorophylls of the c, d, and e types. These methylations play a role in fine-tuning the structural arrangement of the bacteriochlorophyll aggregates in chlorosomes and therefore directly influence chlorosomal absorption properties. 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+2.1.1.333,"The enzyme, found in green sulfur bacteria (Chlorobiaceae) and green flimentous bacteria (Chloroflexaceae), catalyses the methylation of the C-20 methine bridge position in bacteriochlorophyllide d, forming bacteriochlorophyllide c.",384,1.0,-0.0832328,0.0026694883,-0.09416234,-0.030047959,0.016149921,0.10370636,-0.09814242,0.054016035,0.0672569,0.0011853491,0.017753806,-0.0646022,-0.031893156,0.02444781,0.006868641,0.12721466,-0.13847686,0.033201803,-0.02560342,-0.04533847,0.0098761385,0.07301338,-0.055348773,-0.02821483,-0.03727262,0.022347257,-0.0030040897,0.013000149,0.010123464,-0.0532413,-0.007448308,0.07140951,0.030403947,-0.03244446,0.050913807,0.041625515,0.0023440013,-0.10828551,0.097688444,-0.018636018,-0.025557196,0.067371994,0.034518998,-0.006672421,-0.0438682,0.026272971,0.025386967,0.070121795,0.009839107,-0.11378425,-0.006179429,-0.034710348,-0.039819114,0.061166953,0.0107006505,0.01928675,0.007195287,-0.05498807,0.071722165,-0.040630113,0.02175839,-0.0042500678,0.021076879,0.010202705,-0.041545518,-0.03858417,0.023528708,-0.019635255,0.06257584,-0.07688881,-0.06336684,-0.07079627,-0.041628703,0.05371402,-0.010754964,0.022515487,0.047176898,-0.035253916,0.044366363,-0.006647372,-0.031086167,-0.0075121396,-0.02714544,0.04636458,0.031654462,-0.022906952,-0.012911219,0.031792704,0.07837875,-0.014206957,-0.008608928,-0.030642182,-0.07602588,-0.08474874,-0.14757706,0.061167277,-0.009080478,0.01797088,0.037713367,-0.014929525,0.012990973,0.034954697,-0.05187996,-0.05774248,-0.013198755,-0.00060180604,0.033246808,0.13164856,0.0027379887,-0.012826661,0.020655518,0.024329072,0.020910528,-0.018710788,-0.010975901,0.051397063,0.07016543,-0.06843765,-0.06967193,-0.006692362,-0.018066248,-0.07190985,-0.010289251,0.002795304,-0.06503449,0.03366133,-0.16493453,4.7828885e-33,0.081103876,0.027688967,0.053841136,-0.07299614,0.064599,-0.057998948,-0.037599556,0.0666095,-0.028773787,-0.087397106,-0.0795066,-0.069869466,0.023522854,-0.062051684,-0.039948825,-0.010809243,-0.040091313,0.0001612063,-0.04501981,-0.05597467,-0.017231131,0.04056819,0.01546645,0.010885806,0.02624371,0.073047556,0.042847637,-0.005325883,0.10514022,-0.013418865,0.03127062,-0.05647898,-0.06189164,0.059355117,0.091479786,0.041124955,-0.085739344,0.0016417401,0.022891343,0.10064183,-0.000115698065,0.009420556,0.00027564875,0.01639582,0.041548382,-0.048542168,-0.08720653,0.052860115,0.06799464,0.09470484,-0.030570114,0.056216538,0.035980985,0.024417901,-0.047498185,0.047183573,-0.0025929264,-0.034480456,-0.041294497,0.048710816,-0.018761177,0.0598907,-0.015148036,0.039170124,0.012310061,-0.010549588,-0.036028367,-0.003961763,0.04238926,0.080574304,-0.08293599,-0.04541842,0.020504206,0.043936502,0.06096984,-0.040096413,0.010861379,-0.065815836,0.0661858,-0.017932191,-0.024767473,0.013503983,0.017178006,-0.014865203,-0.06384463,-0.08424492,-0.06009788,-0.08007149,-0.028748369,0.020764774,-0.033040937,-0.10725524,0.001052869,0.03192695,-0.07867649,-6.1012664e-33,0.040455177,-0.060510203,0.08429004,-0.10552783,-0.02480262,0.009561557,-0.00027275574,-0.069126494,-0.042060122,0.032622922,0.11728117,0.10007199,-0.022340907,0.027992316,0.046361722,0.021556385,0.13553467,0.06797329,-0.049104184,0.015970284,0.025095057,0.033075772,-0.0070382794,0.0034987314,0.0027088886,0.03503833,0.05846829,-0.030622233,0.094699115,0.017472481,-0.021709545,0.0049522263,-0.0054994533,-0.04577768,-0.003274358,0.034740083,-0.0049050124,-0.0150677385,0.01456701,0.022618536,0.017648341,0.009391691,-0.009076898,0.08595786,-0.004506785,0.04127808,-0.11227504,0.0060506826,-0.009123758,-0.01469432,0.049292527,0.02465306,0.0077033998,0.008541532,-0.0067907874,0.026416816,-0.0020779984,0.035344508,-0.06969653,-0.033089437,-0.022369433,-0.085775755,-0.012518513,-0.028329613,0.06715952,0.055700157,-0.039929684,0.03904896,0.007961377,-0.04053179,-0.0028126123,0.057306457,0.0034485962,-0.020220628,-0.079314046,-0.060711965,-0.03246955,-0.04657027,-0.005769302,0.021021625,-0.0023271523,0.027390257,0.028372966,-0.04349131,0.005802361,-0.09080488,-0.03903317,0.055923905,0.006059118,0.039435,-0.07978251,0.054373477,-0.0062117,0.05966015,0.059022114,-3.7542236e-08,-0.018751012,-0.067341685,0.034014836,0.0054608113,-0.0039011254,0.0803811,-0.057490945,-0.039881267,0.031507388,0.018103937,-0.019942665,0.07005835,0.0072390838,-0.013249743,-0.011130136,-0.0039500105,-0.09319144,-0.044621628,-0.026461523,0.0072428347,-0.076274335,0.047976006,-0.069734536,0.06977805,0.011398087,-0.060168635,0.024668107,0.022566505,-0.020368474,0.01954064,0.048301388,0.051401705,-0.043430477,0.026352352,-0.027576327,-0.012776072,-0.03336489,-0.044466842,-0.050633036,0.037863407,0.060926165,0.061409082,-0.101776294,0.07759136,0.085548595,-0.0059777386,-0.055606388,0.10629987,-0.047756385,0.014282032,0.025645854,0.03278768,-0.0029885676,-0.057503734,-0.11204974,0.0045531127,0.015953062,-0.09432168,-0.05970383,0.003476134,0.02276144,-0.028804962,0.15593371,0.03499219 +2.1.1.334,"The enzyme, found in many bacterial taxa, is involved in a pathway that converts L-methionine to dimethyl sulfide.",384,0.99999994,-0.07678999,-0.049017962,-0.054041542,0.028512353,0.011115121,0.036712483,-0.107700735,0.08441785,0.060652543,-0.0056659314,0.03174492,-0.0828189,-0.004716137,0.060861852,-0.05922244,0.045426358,-0.11484281,0.029247483,-0.016082576,-0.007925048,0.06705036,0.09633292,-0.04597089,-0.0383746,0.081715085,0.0049239066,0.023649734,0.02846841,-0.044299655,-0.023228914,0.03993594,0.0300988,0.039236996,-0.028901728,0.083600946,0.08016573,-0.01095988,-0.0055734445,0.08954725,-0.018363964,0.04401537,-0.002207974,0.058986086,-0.03322517,0.005468663,-0.016763624,-0.038093746,0.027587896,0.05268988,-0.07011792,-0.10101119,-0.017517261,-0.062857114,0.10094684,0.017608272,0.018717842,0.020109722,0.04304503,-0.027928941,-0.042523146,0.009424614,0.017048374,0.012320779,-0.050268702,0.000861753,-0.06675978,0.016192697,-0.076555505,0.068562515,-0.009466566,-0.0726803,-0.047859244,-0.008428397,0.0245729,-0.010965698,-0.03894335,-0.02139809,-0.039791692,0.037611995,-0.07505966,0.031860672,0.036394518,-0.011787807,0.067688994,0.03206169,-0.04411024,0.028310169,-0.0076589426,0.093322635,-0.013205976,-0.053620294,-0.071499124,-0.062593155,-0.08582704,-0.08473064,0.011877324,-0.0020074754,0.055455845,-0.016073085,0.02618717,0.0364999,-0.0076442524,-0.11809558,-0.092584945,-0.08029005,-0.012953642,0.086294875,0.11364666,0.028543597,-0.042586066,0.0871873,0.026467504,0.059386127,0.013034375,-0.020982767,0.09273059,0.07264417,-0.06310076,-0.080313444,0.01791906,-0.021483319,-0.035703927,0.08831142,0.002217647,-0.0017726083,0.033397175,-0.10182049,-1.9260205e-33,0.107781634,0.062154215,0.050641447,-0.05391493,-0.006439523,-0.066262156,-0.092411414,-0.016719824,-0.0247649,-0.0688204,-0.059639912,-0.0775937,-0.0025388976,0.03361405,-0.045584925,0.043903667,-0.03924816,0.005179656,0.03517668,-0.028545562,-0.010534886,-0.035925824,0.009758904,-0.0016342897,0.04528611,-0.0044059395,0.050022297,0.023024408,0.028876541,0.025484601,-0.0062400447,-0.065340936,-0.021582972,0.04819517,0.07630552,0.056167405,-0.103342265,-0.05592565,0.05093414,0.03656588,0.024844894,0.015100381,0.04549706,-0.020897418,0.02794263,0.01943531,-0.05731821,0.073455125,0.025754835,0.0575922,0.059094854,-0.08958652,0.105929226,-0.022005282,-0.08389304,0.0019233943,-0.013472346,-0.029271668,0.032972734,0.07939865,0.008081541,0.022403555,-0.073461555,0.05614408,-0.013713303,-0.009346937,-0.022040814,-0.0072808517,0.0158221,0.09836464,-0.06188211,-0.06638704,0.02312149,0.062421158,-0.0023231169,-0.026848372,-0.023358172,-0.003982501,0.07325791,-0.0055461046,-0.004379134,-0.06840482,-0.01601198,-0.06674822,-0.09542824,-0.020953624,-0.022204071,-0.06176297,-0.016612826,0.0069200876,0.037769757,-0.060241617,-0.02838484,0.014062745,-0.03487252,1.1670254e-34,0.008171268,-0.021670839,0.06505616,-0.072304755,-0.08043052,0.044931773,-0.009289418,-0.03921595,0.070714176,-0.013022431,0.08806799,0.016359879,0.009612825,-0.05782003,0.06638207,-0.0074946824,0.05176227,0.034913864,0.00050238793,0.0055167,0.046479367,0.041657582,-0.050892826,-1.3622632e-05,0.052063383,0.0004061957,0.005435695,0.09085008,0.018399518,0.061369654,0.005081799,-0.005078136,-0.0664321,-0.08123115,-0.04496329,0.054762345,-0.005924623,-0.040944315,-0.0066984524,-0.028998962,-0.0141798165,-0.00367415,0.021090543,0.07942157,0.040873636,-0.007916278,-0.031344175,-0.006127091,-0.0033503934,-0.104436755,0.056184903,-0.048563186,0.050530538,-0.021589734,-0.032931264,0.07522836,-0.059024464,0.023598993,-0.036643676,-0.089832515,-0.03995166,-0.09716106,0.0006488746,-0.0003410398,-0.023756657,0.044453572,0.0298096,0.011816953,0.015782971,-0.043925483,0.023832254,0.010407075,0.04201156,0.019251285,-0.10398116,-0.05279684,-0.1128286,0.023786936,0.033323262,0.0030352422,0.018809235,-0.019196521,0.01765455,-0.06950497,0.019033914,-0.090274066,0.024597814,0.11995696,0.036678057,0.04890891,-0.11062721,0.043904293,-0.03676437,-0.0044029825,0.047175888,-2.620651e-08,0.035544187,-0.050972637,0.03456978,0.052901156,0.0020241393,0.022720244,-0.013013096,0.056992594,0.048016235,0.085546106,-0.03961506,0.10909574,0.0056526735,-0.041006554,0.012159496,0.05349278,-0.013632659,0.035346154,-0.0495107,-0.00048780258,-0.024799041,-0.0124715455,-0.07798845,0.05301137,0.04837186,-0.07056151,0.0100517785,0.05411863,-0.052535243,-0.06501665,0.053945594,-0.02065553,-0.034677364,-0.042465754,-0.0921706,0.008490563,-0.065380335,-0.0803122,0.062575065,0.004644501,0.05013127,0.10256478,-0.07443986,0.055416342,0.0043443483,0.038175765,-0.014512005,0.050718885,-0.0673108,0.008329288,0.075256996,-0.0038369203,-0.007165731,-0.042428438,-0.09893995,0.01777056,0.019354077,-0.0058080326,-0.0010562574,-0.009405039,0.021396084,0.043973956,0.1455992,-0.014815012 +2.1.1.335,"The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics.",384,1.0,-0.040221527,0.023265608,-0.20262875,-0.033351433,-0.004606071,0.032256342,-0.058183074,0.050529066,0.117199354,-0.032003704,-0.032079585,-0.061453205,0.037121348,0.06201368,-0.09029653,-0.048613172,-0.06193225,0.003412364,0.025201933,-0.09007363,0.033748206,0.11073578,0.025144408,0.022069998,0.018083273,0.006955904,-0.0038252717,0.028565401,-0.044625297,0.0064916587,0.051624767,0.02669336,0.05223946,-0.068068326,0.069570825,0.07521812,-0.07417168,0.0051827254,0.112731695,-0.023303479,-0.03512533,0.0019732083,-0.016218562,0.01772196,-0.042746786,0.055487394,0.076946296,0.070245795,0.044097934,0.0052210214,-0.0077770003,-0.0353947,-0.08340558,0.08594988,0.045835264,0.1039932,0.020985927,-0.0009286553,0.006607898,-0.049622867,0.080653846,-0.011554139,0.06932122,0.081309564,-0.08701537,-0.0066869743,0.022748806,-0.08889998,0.010766267,-0.048482846,-0.078831516,-0.036660362,-0.009767706,0.04559712,0.004246616,-0.00250089,0.03908695,-0.005440896,-0.07484382,0.011874992,0.027687885,-0.06092193,-0.031476907,0.06307649,0.0523778,-0.077301905,0.041520145,-0.0063354215,0.06902726,0.031531557,0.056993112,-0.013632922,0.015573708,-0.07181226,-0.052782644,-0.03446899,-0.023629773,-0.026862722,0.008521788,-0.0400988,-0.07683771,-0.01147745,-0.013125319,-0.02147228,-0.032429345,0.03260379,0.006808115,0.014799203,0.02169273,-0.040771704,-0.009831248,0.006268797,0.023139069,-0.0029711006,-0.03331618,0.046630856,0.041554846,-0.07135639,-0.024877518,0.07003886,0.00589464,0.01417911,0.0006269947,0.032211743,0.0152460635,0.043987904,-0.097038925,2.2988502e-34,-0.020923816,0.06756025,0.03108817,-0.08034788,0.08022308,-0.028988047,0.00091683556,-0.039162125,-0.007614572,-0.039565083,-0.08385688,-0.09808294,0.033283398,0.045606025,0.051100686,0.024362957,-0.0019703591,0.05707279,0.0019647314,0.042148124,-0.026504386,0.056951486,-0.050833333,0.008193307,0.054104265,0.08710694,-0.009695486,0.026534569,0.091046914,-0.021556186,-0.006674521,-0.056321975,-0.064564705,0.0009974372,0.1009935,0.0019527756,-0.07158179,-0.031032596,0.05741753,0.040534396,0.0128340535,-0.006719583,-0.027765824,0.0099582225,0.023818482,-0.044257645,-0.048787717,0.060119852,0.063102126,0.051588915,0.06059852,-0.045999072,0.07633421,-0.010346075,-0.04836756,0.038852915,-0.052375983,0.059777968,0.05121575,-0.0096734855,-0.05724304,0.0018961165,-0.041764084,0.023005301,0.01911958,0.004587372,-0.05239128,-0.039405998,-0.04277923,0.019361561,-0.078165285,0.044451404,0.03802444,0.032332953,0.033769477,0.035927866,-0.042142496,-0.07026212,0.12688391,-0.04735337,-0.034189664,-0.020580512,0.022620838,-0.07486068,-0.049994238,-0.006501344,-0.05936047,-0.048604824,-0.008323402,0.08152609,-0.0018841453,-0.07318611,-0.12688506,0.04381935,-0.02019623,-3.0364009e-33,0.052536987,-0.05679165,0.018990388,-0.03812516,-0.040021088,0.09509652,-0.06787583,-0.067538165,0.014884547,-0.054602075,0.05113695,-0.052267894,-0.027623361,-0.048227623,-0.04013832,-0.036349814,0.06889113,0.083787665,-0.02091216,-0.011536799,0.062009424,0.020149337,-0.0075694886,-0.07341526,-0.014501069,-0.008679669,-0.03323128,0.07799882,0.056090113,0.077325866,-0.018935883,-0.04408002,-0.032297574,-0.015740693,-0.029707642,0.1473457,-0.057796262,-0.033814322,0.1077924,0.02858541,0.1010429,0.011844021,0.03815231,0.0719488,0.012738824,0.037837494,-0.059962973,0.0648029,-0.010480931,-0.0751886,0.0351251,0.043192867,0.06419934,0.02640544,0.043658406,0.010616,0.02606199,-0.047705654,-0.036654137,-0.07837741,-0.029171707,-0.0618499,0.011945277,0.023529125,0.030049553,0.008354447,-0.061068185,0.041450717,0.07509945,-0.0021893857,0.037993427,-0.020776395,-0.038048334,0.007988783,-0.037305977,-0.046613123,-0.086854674,-0.052781567,0.040729746,-0.037055075,-0.02227412,0.035360303,0.05822952,-0.079599276,-0.017991282,-0.05148801,0.0065965345,0.032019872,0.056535155,0.026850725,-0.02617072,0.020949095,-0.0442854,0.014177592,0.09375312,-2.568457e-08,0.06669822,-0.037556924,0.063805014,-0.01590588,0.037150655,-0.027032178,0.0038195564,-0.019775238,0.0017472756,-0.054555915,-0.016150948,-0.009251056,0.0030007567,-0.03375928,0.008692494,0.08228028,-0.085432515,-0.06763023,0.030313402,-0.018267427,-0.08092505,0.0072949016,-0.101445585,0.009120075,0.022679862,-0.014771904,0.014916552,0.011930532,-0.06967615,-0.007599104,0.018975848,0.003344936,-0.057390008,-0.0066557047,-0.08042232,-0.0470195,-0.080896415,-0.032991733,0.038437754,-0.014046584,0.0025660046,0.07636049,-0.09606776,0.021583524,-0.047180533,0.035329297,0.0006950356,0.0032257852,-0.08100907,-0.09127435,0.072248966,0.014116374,-0.018317482,0.02816764,-0.06024134,0.04172866,0.016081266,-0.02216396,-0.05746078,-0.049371008,-0.034866866,0.018076327,0.16948529,-0.046608303 +2.1.1.336,"The enzyme, characterized from the plants Nerine bowdenii and Narcissus pseudonarcissus (daffodil), participates in the biosynthesis of alkaloids produced by plants that belong to the Amaryllidaceae family.",384,1.0,-0.06213418,-0.045591086,-0.09818673,0.017385118,-0.018195225,0.039202113,-0.0623164,-0.036425307,0.06697776,-0.030947732,0.01094738,-0.078973114,-0.015070844,-0.05870745,-0.10115695,0.055187974,-0.06958235,0.036453933,-0.025216635,-0.09474408,0.055304848,0.10030271,0.005605357,0.015164702,0.07894273,-0.019788168,-0.063232884,-0.01766388,-0.0010019924,-0.044127867,0.020648906,-0.03111162,0.038595572,-0.029308202,0.019163301,0.045105286,-0.07620792,-0.004922913,0.06917097,0.060931277,0.046104454,-0.0078567285,-0.03610896,0.021002835,-0.10222493,-0.0010098683,-0.08654528,0.016596593,0.043053884,0.002110219,-0.0734451,0.021779787,-0.017512769,0.025776576,0.033749167,-0.0133051695,-0.0049148495,-0.005925141,-0.038591456,0.045381587,0.099067464,0.02788618,-0.021857578,0.036610182,-0.06283772,0.03211671,-0.033705186,-0.04312185,0.07921793,-0.070393495,-0.026277231,-0.104294315,-0.024094753,0.014063493,0.0038697931,0.017018065,-0.02121106,0.012042592,-0.011434224,-0.04564852,0.061881736,0.05899242,0.011601663,0.060166925,-0.024208665,-0.004486248,0.07917097,0.02994681,0.00470078,-0.04129754,0.04756056,-0.043926813,-0.04228442,-0.09748794,-0.05991327,0.0487897,0.044766817,-0.023290616,-0.050004598,-0.025688436,0.028800342,0.02543585,-0.05043603,-0.06934962,-0.05427028,-0.026102284,-0.070284314,-0.022697177,0.009983987,-0.0065224306,0.03023977,-0.017026277,-0.030360384,0.018132366,0.0018878488,0.047222875,0.007889601,-0.09674312,-0.059744533,-0.008549568,-0.021997029,-0.058429524,0.0075696763,0.11918186,0.027746616,0.020827416,-0.10992604,2.3516248e-33,0.049117547,0.05730426,-0.034121584,-0.046279747,0.02856736,-0.08809898,-0.08884016,0.0079847025,-0.031231593,-0.005113295,-0.04019922,-0.0117578525,-0.0053148996,0.01765793,0.01592703,0.00080188696,-0.012076351,-0.034198992,0.0814016,0.010935292,-0.03263518,0.08169098,-0.09883524,0.059728373,-0.029636353,0.08836785,-0.004215271,0.013904253,-0.0058214134,-0.018068144,0.038206108,-0.12527291,-0.0275843,0.06891526,-0.033332955,0.014744893,-0.040408622,-0.046588197,0.030694686,0.044831857,0.047444485,0.06850683,0.061709978,0.045202788,0.05641032,0.00526847,-0.038477696,0.06773619,0.06150298,0.0932128,0.0073923673,0.006321468,0.18781598,0.028642476,-0.055020213,0.030376883,-0.07004211,0.008480333,0.01775017,0.08414633,-0.05329881,-0.035541795,-0.024182087,0.044434268,0.023876006,0.012022609,-0.021751598,-0.07357723,0.072883464,0.06419202,-0.09692034,-0.016035989,-0.013471104,0.075523674,0.021867055,0.0061071003,0.02500002,0.029075198,-0.054787178,0.012635375,-0.0109657,0.014769855,0.031216819,0.020793289,-0.029971052,-0.09091563,-0.03610824,0.004518814,-0.030531656,0.03887482,0.0047627483,-0.010239655,-0.06636652,0.048489623,0.04435319,-3.684606e-33,0.10932902,-0.09174762,0.022215633,-0.056091815,-0.05682426,0.0875824,-0.04419807,0.053906083,0.034161996,0.04531343,0.058097545,0.061091717,0.040513404,-0.039982498,-0.00506819,-0.08515145,0.11022482,0.09976676,-0.028331546,0.01172885,-0.06252133,0.11183943,-0.04146862,-0.038525928,0.07046467,0.031120824,0.048405606,0.012635935,-0.055110607,0.008906069,0.083708726,0.06230169,-0.0627583,-0.058147732,-0.020706885,0.04440511,-0.023100998,0.002440098,-0.053022735,0.06443049,0.018300427,0.06616969,0.04719025,0.07794007,0.06351304,-0.03002457,-0.07416365,0.061635036,-0.033049542,-0.06272662,0.0480756,0.025102526,0.068027176,0.028802019,0.02668365,0.031587075,0.05512557,0.019677823,-0.027801728,-0.0042549325,-0.021221723,-0.0190736,0.03482012,-0.053557124,-0.061918363,0.033333946,-0.028393017,0.046346202,-0.0010442585,0.03148503,0.027311035,0.041838605,-0.004342697,0.05643624,-0.07918903,-0.020342438,-0.038777,-0.026042122,0.008131824,-0.028635602,-0.010261437,0.022414286,0.02543899,-0.05504263,-0.03302516,-0.019093845,0.024726866,0.10971555,-4.4821096e-05,0.02768197,-0.0027863437,-0.044488974,-0.11196459,0.032536257,0.05042095,-3.3874663e-08,0.04598793,-0.003999886,0.015240005,-0.030600695,-0.024332335,0.037791803,0.006367485,-0.03471949,-0.037430506,-0.053328283,-0.015615757,0.07467727,-0.052032962,-0.0057276683,0.022666428,0.049139597,0.038244534,0.03210906,-0.036543366,0.0723299,-0.03799453,-0.0036772802,-0.119989656,-0.0059216763,-0.019299246,-0.084103286,0.07239889,-0.021395335,0.023109745,0.0681423,0.040735833,0.014302027,-0.029601544,-0.051684473,-0.021286339,-0.050708886,-0.034724385,-0.07421297,0.03360687,-0.033680968,-0.0001609993,-0.031888872,-0.023417274,-0.01320091,-0.083102636,-0.021078948,-0.017471086,-0.025326328,0.06386946,0.032061584,-0.0020513677,-0.033083294,-0.010419438,-0.08830831,-0.09447899,-0.053334907,0.023712056,-0.06819622,-0.03924399,-0.032930195,-0.021244274,0.044072296,0.2237139,0.026513847 +2.3.1.253,"The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase. The mechanism involves the cyclization of an activated 3,5-dioxoheptanedioate intermediate. The enzyme exhibits broad substrate specificity, and can accept C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming 6-(polyoxoalkyl)-alpha-pyrones by sequential condensation with malonyl-CoA.",384,1.0,-0.044724863,-0.079444736,-0.06160352,-0.036001835,0.055417188,0.057125032,-0.06790108,0.014528242,0.029686423,0.015478319,0.0063875155,-0.03510096,-0.069933414,0.0461704,-0.11657303,0.02723854,-0.12992401,-0.035215054,0.05049501,-0.007982359,0.01045925,0.055353746,-0.044852614,0.05406937,-0.010426183,0.026153581,0.089457884,-0.009664988,-0.011310467,-0.00994021,-0.033043303,-0.020374086,0.05237439,-0.033534624,0.065238506,0.11471949,-0.072856925,0.05051131,0.09177841,0.014003994,0.09159303,-0.07679891,-0.019604718,-0.044913292,-0.034329087,0.029247513,-0.019754793,-0.018469248,0.10970034,-0.0741659,-0.02892812,-0.015068079,-0.053240173,0.0024089362,0.006779227,0.032089017,-0.0013959601,-0.02446012,-0.03670965,-0.042091906,0.014306929,0.020004014,-0.0069388603,0.011400047,-0.01063302,0.035345003,0.017379517,-0.036063187,0.009710815,-0.06028797,-0.14515817,0.0003031164,0.011969543,0.027280897,0.0038304413,0.0061174366,1.0652078e-05,-0.041558057,-0.002562455,-0.030213442,0.01730165,-0.028589005,0.055880856,0.07987232,0.009205009,-0.041431215,0.017558793,-0.022175528,0.038719933,-0.010985028,-0.019962618,0.018617846,-0.036647502,-0.037303496,-0.03197974,0.08407536,-0.025529113,0.0070774304,0.068923354,-0.012265732,-0.0057911207,0.014106793,-0.020460788,-0.11208727,-0.043982394,-0.0062226183,-0.0084323585,0.03770797,0.06534859,0.009959825,-0.055867575,0.010859664,-0.0072440715,-0.10594591,0.011918392,0.08070648,-0.012786939,-0.015333077,-0.029597051,-0.022783691,0.021107249,-0.027064782,0.03443572,0.038754497,-0.076616496,-0.041139282,-0.083074406,3.59075e-33,0.07657916,0.063931696,0.051195055,0.037672885,0.015227074,0.008589626,-0.04151179,-0.0419517,-0.081487395,-0.026932511,0.020263683,-0.084273264,-0.018190188,0.005724901,0.03834262,-0.046412755,-0.039135367,0.0330769,0.010024434,-0.011626016,0.05240493,0.0152584845,-0.04135421,0.028382871,0.0645972,0.06487104,0.041356917,0.024083627,0.0037295148,-0.039241597,-0.011607053,-0.03163169,-0.12092926,-0.029715264,0.03444545,-0.05523659,-0.048910346,-0.030044913,0.0034305968,0.07067513,0.047238085,-0.01767981,0.017875915,-0.050741706,0.08363296,-0.0148051735,-0.075537436,0.13994849,0.005087187,0.119208135,0.014916537,-0.023615832,0.066764735,0.0660304,-0.04989779,-0.0076576984,-0.031436723,-0.026341256,0.017887801,0.0041701244,0.086357005,0.049531,-0.06899493,0.0148816975,-0.044929422,0.04941477,0.014371051,0.010255468,0.046140406,0.058136906,-0.05886746,0.0108625665,-0.017848957,0.056034118,0.044758286,-0.03173033,-0.08604347,0.027584244,0.052476503,-0.009419168,-0.04674345,-0.037739508,0.026195494,0.015559089,-0.060939733,-0.002662147,-0.021008404,0.009323908,-0.017192313,0.0035652271,0.082577795,-0.13974504,0.0019706003,0.12852822,-0.057186276,-3.7325068e-33,0.11336694,-0.102874115,0.050125957,-0.09910979,-0.057794288,0.021744987,0.04907189,0.01660088,-0.025742717,-0.010780549,0.057040665,0.037800733,0.031855073,-0.00067379896,0.007280081,-0.0008114373,0.04193082,0.025798723,0.040356908,0.02711298,0.11455288,0.011329159,-0.064313,0.013213003,0.082727194,0.05238268,0.0176948,0.11236987,0.031632658,0.076571405,-0.037845597,0.042424783,0.023850301,-0.0073361876,-0.047045156,0.017994251,-0.06532012,-0.00926259,-0.02354373,0.038310792,-0.010852662,0.039663356,-0.04188753,0.02090277,-0.049243134,0.07626491,-0.041583035,-0.010766627,0.05179164,-0.070268415,-0.0077576167,0.041610558,0.006090614,0.011350694,-0.030420287,0.034155343,0.0069689015,0.015030342,-0.0050614807,-0.06932208,-0.043904614,-0.11238701,0.07540686,0.020338722,0.022623269,0.09506938,-0.00740458,0.048552874,-0.0038879544,-0.017393908,0.053944767,0.033555984,0.044264596,0.04730895,-0.07400072,-0.02560644,0.021239508,0.0020509677,0.046443228,0.052037254,0.025237095,-0.06399778,-0.024209816,-0.059173875,-0.04468784,-0.118067354,0.08706884,0.022134496,-0.013966139,0.055985242,0.020322548,0.027679376,0.036239956,0.055068545,0.03545067,-4.555458e-08,-0.0143174045,-0.060494825,0.0142085785,-0.012123,0.034047533,0.022637228,0.012610544,-0.067763604,-0.021544518,-0.06081255,-0.04290997,0.012172792,0.04068498,0.0034687198,0.07769915,-0.008725286,-0.049158484,0.016146738,-0.012006218,-0.025228791,-0.08470265,-0.0020314066,-0.16168495,-0.048331495,0.060444765,-0.05015446,0.07169542,0.01212608,-0.018162083,0.040097795,-0.06459565,0.04089704,-0.005519549,-0.037606664,-0.043077454,0.085427344,-0.041103948,-0.076463096,-0.060295958,-0.04887576,0.021415623,-0.0072209476,-0.079853915,-0.019038558,0.05889153,0.002946528,-0.029813806,-0.02121809,0.015160741,-0.027483592,0.10516076,0.024908287,0.04595493,-0.030837521,-0.0924295,0.10014562,-0.0045649437,-0.033054914,-0.07800066,-0.040019773,-0.038540885,-0.027797282,0.20923163,-0.012923484 +2.3.1.254,"N-terminal acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatB complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to Asn, Asp, Gln, or Glu residues at the second position.",384,1.0,-0.060894765,-0.03866455,-0.08059551,0.023547333,0.079674736,0.05099523,-0.015903816,0.01492529,0.041899115,-0.03490376,-0.008273702,-0.024369376,-0.12567784,0.04307771,-0.06775837,-0.032691486,-0.10103557,-0.023684448,0.018410152,-0.04998693,0.018235762,0.10004298,-0.075232744,-0.061117798,0.03851416,-0.053016294,0.057612333,-0.08331194,0.033035032,-0.12245838,-0.0083126305,-0.06503261,0.034425147,0.010263961,0.032621454,0.036235236,0.0027084728,-0.06319588,0.050459716,-0.031285174,0.10859491,0.01665997,0.03966143,-0.006529734,0.009368253,-0.0020988435,-0.069603235,-0.021608729,0.10070937,0.01400074,0.0010965354,-0.0058756764,-0.047344,0.07499324,-0.015125273,0.05132749,-0.039103836,-0.03756439,-0.0043484573,0.019378467,0.054730576,-0.017956806,0.03005302,-0.022920523,0.052807752,-0.030120786,0.037599944,-0.0483406,0.032804906,0.036090866,0.000101934624,-0.053545088,-0.07153603,0.026146239,0.0034114376,-0.033669963,-0.074602254,0.022696525,0.027273428,0.036784526,0.06818564,0.02728496,0.04962945,0.08606591,-0.014408413,0.009468349,-0.06485219,0.0073328624,0.114069074,-0.02748406,-0.070390716,-0.008590722,0.04777597,-0.014135961,-0.084585354,0.0033777226,0.07887355,0.010977319,-0.090895586,0.012695845,0.0412009,0.0723835,0.0026585958,-0.035372447,-0.07256259,0.079636015,0.04331203,0.013150502,0.042228155,0.014831462,0.012335307,-0.023458889,0.089914136,-0.058070503,-0.047425218,-0.015194655,-0.032542694,-0.043056097,0.073195286,-0.048693195,0.038460236,-0.023687743,0.014622253,0.033994224,0.020454474,0.10501923,-0.12566625,1.6368623e-33,0.06731912,0.04439511,0.00216661,-0.024569148,0.04248738,-0.10358841,-0.03813703,-0.026192294,-0.027675813,-0.032979153,-0.00059901865,-0.06587829,0.014137108,0.033151444,-0.032047275,0.026884848,-0.051097874,0.036270294,0.011891708,0.033272453,-0.07031397,0.0020414283,-0.046750687,0.04810829,0.062135156,-0.041066125,-0.038401004,0.029792514,0.024678262,0.009863713,0.031060109,0.047598984,-0.08805924,0.041021943,0.05900602,-0.026225552,-0.016557092,-0.04617916,0.037703425,0.032920852,0.026942087,0.068620585,-0.031261504,0.030598199,0.027370637,-0.04955513,-0.084733084,0.07609128,-0.05024497,0.026362384,0.0136516355,-0.019509094,0.03597151,0.050539035,0.023946514,-0.006317544,-0.087748565,0.022333348,0.028666789,0.051582083,0.06052015,-0.049267586,-0.028040547,0.07853,-0.020944515,0.09409997,-0.03144585,-0.009305418,0.051887695,0.012229984,-0.056797724,-0.021109592,0.093838416,0.06644471,0.013993139,-0.060895137,0.0007741558,0.0832,0.012196193,0.074569255,0.030246297,0.016776713,0.013200772,-0.047010873,-0.026083488,-0.04517043,0.06258711,-0.053837255,-0.016795477,-0.07189748,0.07598819,-0.006444021,-0.072455496,0.029890805,-0.048520695,-2.4031513e-33,0.089429945,-0.12649712,-0.036449846,-0.0904121,-0.111364186,-0.007867351,0.08303181,-0.10770468,0.031604912,-0.028587567,0.030962607,0.041377977,0.005971298,-0.03365544,0.08814505,-0.055201992,0.0029627478,0.09132909,0.018820569,-0.057114467,0.034508906,0.045307912,-0.025771955,0.0421982,0.055871755,-0.0483159,-0.0510192,0.018224634,-0.03267428,0.04231251,0.017702177,0.047860015,-0.071642734,-0.04629346,-0.008245218,0.10457915,0.00597727,0.019349761,-0.027467774,-0.053645942,0.045775287,0.00015500664,-0.036459032,0.0031403475,0.040249024,-0.03816033,-0.07030878,0.022558063,-0.019808386,-0.04041912,0.016488457,-0.05413057,-0.009175086,-0.055400435,-0.04326869,0.096732445,0.0662468,0.03980288,0.05940805,-0.026403429,-0.026210368,-0.044230696,-0.00615628,-0.022087175,-0.0044832253,0.012915596,0.009555936,0.04363535,0.08016837,-0.008997021,-0.05122121,0.05508893,0.13020244,0.12053906,-0.053718638,-0.022576414,-0.049192563,-0.04310496,-0.07547952,-0.024157532,-0.07225359,-0.00014976901,-0.03344483,-0.017864363,0.008386382,0.009519447,0.052312892,0.107191846,-0.08849282,0.032250434,-0.027164746,-0.0743619,-0.09827096,0.08862162,0.024123058,-4.5206857e-08,0.12896836,0.04431187,-0.021452108,-0.04887204,-0.049388498,0.048904248,-0.03960158,-0.031750843,0.0063029733,-0.03614293,-0.025590124,0.11757768,0.03143656,0.05837595,0.022392986,0.048801824,-0.01910834,0.0061083264,-0.061513346,-0.0073218434,0.0043971273,0.023037694,-0.06854611,0.052315786,-0.047028705,-0.053640485,0.086640984,0.1093733,-0.037031136,-0.04994605,-0.028983973,0.02149306,-0.014817569,-0.016236667,0.027510675,0.00733762,0.008622415,-0.065802,0.018924497,0.035101272,-0.011603036,-0.03175012,-0.038754605,-0.003509303,-0.036397114,0.01914295,0.00813135,0.01034428,-0.03279915,0.036450904,0.05628027,-0.020594332,-0.07152861,-0.013830669,-0.016159175,-0.044737194,-0.034083232,-0.0011133284,0.03393631,0.042629525,0.014996729,0.024248099,0.13839445,-0.061735626 +2.3.1.255,"N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. The NatA complex is found in all eukaryotic organisms, and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val residues, that became available after removal of the initiator methionine.",384,1.0,-0.07638186,-0.032631487,-0.06562913,0.011183976,0.08132128,0.03348785,-0.044303544,0.00044462658,0.050455105,0.010982798,-0.007538466,-0.03028301,-0.117278576,0.05765502,-0.07896935,-0.029793732,-0.09029855,-0.026012883,0.040175125,-0.03864709,0.010870698,0.093293734,-0.061280068,-0.001823752,0.034265056,-0.021092204,0.067036286,-0.0564112,0.039949905,-0.115565196,-0.011667143,-0.053676363,0.018415185,-0.006304534,0.02432409,0.053488277,0.014565866,-0.057130355,0.055023223,-0.013111563,0.11404365,0.009972015,0.03272874,-0.035997137,0.016445266,-0.013963556,-0.066829965,-0.02529346,0.11763332,0.03102277,-0.00015214909,-0.025272071,-0.04611829,0.058415454,-0.00014720179,0.045366514,-0.013686462,-0.05440179,0.010758866,0.01273052,0.054956153,-0.038217895,0.029986791,-0.0040343213,0.041856088,-0.04823354,0.042789593,-0.035631344,0.019018736,0.0223043,-0.009071878,-0.062163576,-0.047533367,0.038323767,-0.0017400273,-0.04120623,-0.063568436,0.0014558135,0.01119501,0.06079404,0.064358406,0.035752255,0.032364566,0.10174744,0.00874632,0.020418793,-0.056687053,0.0073034912,0.12207765,-0.029139612,-0.06412479,0.002676172,0.04528034,-0.055686247,-0.07638011,-0.014551822,0.052952524,0.011035867,-0.08278488,0.018265814,0.05116792,0.05886277,-0.010551491,-0.06834535,-0.09539935,0.094885685,0.03686777,0.018079901,0.049627736,0.05958472,-0.0049119615,-0.058821633,0.08870556,-0.059914555,-0.06371267,0.038264327,-0.07983745,-0.048302785,0.06562524,-0.0631311,0.02951755,-0.040848106,0.05004368,0.032646958,0.04194584,0.091812484,-0.10274659,6.468053e-34,0.09008586,0.06474956,0.01784449,-0.0060760593,0.07129978,-0.096123725,-0.022018319,-0.01120214,-0.004052364,-0.04311241,0.013258784,0.00019433917,0.016684452,0.0036737884,-0.031168759,0.02938979,-0.010401958,0.030328412,0.0076970276,0.037550665,-0.04912309,0.014904544,-0.027628677,0.04100008,0.04448262,-0.023980167,-0.04974882,0.010979714,0.027484361,0.005516766,0.034532662,0.061572023,-0.093552664,0.03271619,0.059596226,-0.039876685,-0.004648134,-0.04568097,0.0424122,0.045769613,0.025870908,0.057628073,0.0063335793,0.0074015995,0.006667748,-0.06828062,-0.080963075,0.043216832,-0.038798567,0.031298663,0.028753595,-0.03040025,0.052969296,0.055250585,-0.023311438,0.0033560172,-0.07839557,0.007587362,0.028938882,0.02862614,-0.0009901733,-0.041835673,-0.0047710235,0.04809978,-0.054821495,0.06643663,-0.044150505,-0.017949112,0.0475506,0.03115846,-0.0452132,-0.0026522167,0.08355876,0.08151566,0.028106904,-0.0859672,-0.019930398,0.062117077,0.005033793,0.079553,0.019798428,0.0071769645,0.0005972639,-0.032613218,-0.0064911535,-0.035212703,0.06910189,-0.026790524,-0.008749098,-0.04977362,0.062343445,-0.012436383,-0.058926154,0.020373216,-0.032080945,-2.1667584e-33,0.13080822,-0.13911803,-0.041349463,-0.09854794,-0.11645183,-0.009622979,0.054761767,-0.068414025,0.035169255,-0.048339967,0.049876623,0.034233216,0.009712912,-0.0209099,0.07019273,-0.058890834,0.0014773256,0.090941645,0.031092381,-0.08719903,0.048731156,0.02379672,-0.021647917,0.008001549,0.08330523,-0.056538045,-0.05296362,0.0149144195,0.0045815683,0.054401506,0.0077549308,0.04361883,-0.067831434,-0.01933314,-0.0030609781,0.11492414,-0.008774253,0.011975633,-0.046531223,-0.02176651,0.053406008,0.004057421,-0.019329146,0.027932776,0.05205189,-0.04576424,-0.07148327,0.028562417,-0.014162464,-0.022696264,0.03177769,-0.048140522,-0.008368537,-0.052689575,-0.020755902,0.07853921,0.046984613,0.057811834,0.06671483,-0.02632745,-0.003814592,-0.039982412,-0.04783087,-0.013856405,-0.011144636,0.025994712,-0.011123126,0.045179278,0.068872705,-0.01588663,-0.048723083,0.039575454,0.1219235,0.1092923,-0.0042663333,-0.0051073385,-0.059705235,-0.0680432,-0.058496818,-0.069207765,-0.0892442,-0.0057754894,-0.04437486,-0.04110517,-0.023313787,0.0071297335,0.07754996,0.070179015,-0.11809707,0.017178142,-0.025267055,-0.073088594,-0.07563777,0.07728883,-0.0004814788,-4.781866e-08,0.11813804,0.013023545,-0.032438383,-0.026192406,-0.04545103,0.03366435,-0.041666895,-0.02143223,0.026160397,-0.06064891,-0.009108932,0.11502394,0.043026697,0.082079686,0.035579734,0.052646413,-0.0114934165,0.011091433,-0.07815303,0.0025839023,-0.02210323,0.03034596,-0.089996286,0.03157391,-0.0929224,-0.036579456,0.10339459,0.09691092,-0.08615163,-0.047594666,-0.045532014,0.0197998,-0.03117856,-0.018822337,0.04328485,0.009396797,-0.0014490546,-0.050983455,0.010558102,-0.00023183432,-0.019126656,-0.031712066,-0.08651967,-0.0300243,-0.022010915,0.017182544,0.004072725,0.007844652,-0.029964274,0.024404299,0.043730423,-0.011677039,-0.06502215,-0.03278898,-0.0078712255,-0.056947514,-0.0056184796,-0.014297568,0.024594327,0.027770791,0.040402222,0.012656457,0.15634227,-0.065316774 +2.3.1.256,"N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues.",384,1.0,-0.061576888,-0.05770546,-0.06300623,0.0017185968,0.105229415,0.03899815,-0.016916584,0.01651036,0.052904606,0.00050339854,-0.0013263243,-0.04269955,-0.12688121,0.066945516,-0.056834362,-0.04070294,-0.10827342,-0.0021382547,0.037099935,-0.039362524,0.025603453,0.091562495,-0.065458626,-0.040737025,0.027187275,-0.048041344,0.06979789,-0.034071393,0.026909176,-0.10709681,-0.02546889,-0.057632264,0.01971029,-0.016998889,0.017881166,0.0336735,0.005197956,-0.0747586,0.0667816,-0.03153609,0.11625863,0.0114175035,0.016457878,-0.02721948,0.00021743942,-0.008045205,-0.07741708,-0.01795216,0.08566088,0.023403909,0.005148994,-0.0035971962,-0.06311011,0.06930997,-0.03924372,0.04181404,-0.0077403374,-0.039738145,0.014875719,0.032690775,0.04942173,-0.02731901,0.037778284,-0.009719631,0.044583093,-0.06473077,0.031320155,-0.030674271,0.052705534,0.03997617,-0.016182082,-0.053509206,-0.056057002,0.02690541,0.011312862,-0.04366553,-0.07348469,0.0033333276,0.013008294,0.048420392,0.04417891,0.02199728,0.023432432,0.088813275,-0.0019597611,0.009356944,-0.02966908,-0.006130889,0.12745911,-0.042233825,-0.043564383,-0.012649578,0.042834617,-0.03354638,-0.080709554,-0.008750663,0.06161457,0.01023804,-0.118785486,0.010716301,0.042102545,0.059055224,0.00032588575,-0.05119065,-0.059589937,0.07730393,0.059109773,0.02295891,0.028677503,0.026116468,0.0058641518,-0.03359194,0.1021895,-0.035396867,-0.06467202,-0.024188278,-0.037810013,-0.0591541,0.088342175,-0.040075358,0.028391186,-0.067883916,0.027434248,0.032260984,0.04099907,0.07775465,-0.11157959,9.460254e-34,0.06731636,0.036978357,-0.001530442,7.144967e-05,0.0476786,-0.10213799,-0.04045433,-0.024916327,-0.024238342,-0.02595489,0.0010790066,-0.057863392,0.008251279,0.020672493,-0.03826067,0.040224552,-0.04992473,0.036909398,0.0053847777,0.040809836,-0.07250575,8.540443e-05,-0.025178429,0.018134557,0.080452845,-0.034629975,-0.07536721,0.029542096,0.060060307,0.019337354,0.04083113,0.048526745,-0.06457182,0.046960708,0.0716831,0.002068603,-0.013077579,-0.04907007,0.043045048,0.030538397,0.030790564,0.06180678,-0.0012164774,0.015526407,0.020649487,-0.034189716,-0.07268765,0.081230305,-0.077512294,0.014040157,0.024421737,-0.03334423,0.020360608,0.042287983,0.010995228,-0.03751243,-0.09256315,0.0018714021,0.029018179,0.063923895,0.02628084,-0.03883302,-0.030938698,0.09182872,0.0033219522,0.061861314,-0.042728774,0.010379139,0.06864818,0.012638384,-0.048752,-0.031766642,0.10215149,0.07679727,0.021029176,-0.08206828,-0.005261342,0.04897359,0.007937967,0.08295067,0.04510696,-0.0067621353,0.021841621,-0.05412207,-0.030277684,-0.034917355,0.048540182,-0.040002532,-0.0170741,-0.075397335,0.078276545,-0.0108128,-0.05806385,0.038755897,-0.06606133,-2.2090123e-33,0.09797668,-0.12758112,-0.022759128,-0.1015405,-0.1261742,-0.013729704,0.06524775,-0.084271505,0.045236804,-0.040692378,0.051908575,0.022540873,0.0033858614,-0.04547538,0.07939168,-0.054176316,-0.0046422333,0.057427827,0.01762698,-0.054784548,0.03189086,-0.0041611576,-0.0076572536,0.036355175,0.062570274,-0.04021157,-0.04719909,0.021624502,-0.037279755,0.040471956,-0.022779671,0.028447228,-0.08085171,-0.030557193,-0.0019141387,0.09055784,-0.013882197,0.024985636,-0.008536859,-0.030248297,0.052219886,-0.023889057,-0.039687768,-0.009478838,0.02942555,-0.05409474,-0.053258907,0.036472835,-0.008364659,-0.03340873,0.03176474,-0.05564981,-0.019302957,-0.034876186,-0.034503877,0.10171502,0.05198042,0.03747786,0.06488875,-0.034618393,-0.016465157,-0.023996286,-0.037125368,-0.020621222,-0.0114524355,0.022040473,0.0071814507,0.08026044,0.08496832,-0.01939829,-0.046160903,0.04949117,0.1318197,0.08802007,-0.046739932,-0.034454048,-0.06291372,-0.04976883,-0.06499845,-0.025293985,-0.06270012,0.0159016,-0.056794044,-0.040240172,0.03194986,0.038125046,0.042631596,0.09510975,-0.0863839,0.032997154,0.007774155,-0.0630883,-0.08212939,0.08085631,0.026656346,-4.6739675e-08,0.13860437,0.024119021,-0.029706074,-0.04803187,-0.06856328,0.043046843,-0.035314742,-0.032049775,0.013861593,-0.009061776,-0.0056895833,0.14343731,0.020413555,0.06716442,0.038187817,0.060624197,-0.023936732,0.017833576,-0.07262668,-0.016410692,-0.009561089,0.018422015,-0.081042,0.048563,-0.0575001,-0.051557384,0.080891855,0.10183067,-0.05759451,-0.0378041,-0.028726384,0.0033499843,-0.035973996,-0.019692084,0.06413711,0.024526916,0.0007123421,-0.07655086,-0.008689885,0.03183962,0.009272217,-0.02531452,-0.060218204,-0.020208871,-0.010831691,0.028381683,-0.0071747373,0.02719283,-0.017004453,0.046135664,0.054777414,-0.016758893,-0.045729753,-0.030379854,0.0012894081,-0.059799165,-0.016775768,-0.0031005822,0.0080251265,0.048092257,0.034589484,0.044946667,0.14359131,-0.061514836 +2.3.1.257,"N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. NatD is found in all eukaryotic organisms, and acetylates solely the serine residue at the N-terminus of histones H2A or H4. Efficient recognition and acetylation by NatD requires at least the first 30 to 50 highly conserved amino acid residues of the histone N terminus.",384,1.0,-0.025945446,0.0045048334,-0.069329865,-0.071616426,0.059338536,0.078168966,-0.058933787,-0.037242673,-0.014631942,-0.013123605,-0.00072891085,-0.008751027,-0.121726915,0.060589157,-0.06278252,-0.0028523295,-0.078514345,0.01372256,-0.011778376,-0.105100214,0.011976155,0.08594288,0.00062365556,-0.058322433,0.03229345,-0.04414181,0.07233774,-0.050624866,0.048995838,-0.10134804,0.019745357,-0.079320505,-0.008584134,-0.02180396,0.055133965,0.022797737,0.044136945,-0.031154985,0.037742395,-0.026937567,0.07926409,0.015113023,-0.03672571,0.0060440134,-0.019415302,-0.0014198653,-0.055188794,-0.04321144,0.0857897,0.014031623,-0.0033510062,-0.005520843,-0.025409324,0.0028076037,-0.016574932,0.04282268,0.027605662,-0.10389456,0.004178527,-0.006472084,0.056895986,-0.06010533,0.030126665,-0.007787451,0.05717611,-0.053105377,0.0555328,-0.06776785,0.024652155,-0.004380287,-0.013484693,-0.05654845,-0.03423929,0.056507178,0.021242548,-0.05049877,-0.08415999,-0.006961471,0.0036786995,0.023808364,0.027588056,0.024003334,0.07829406,0.09882074,0.04710059,-0.0022714483,-0.040943537,0.01685347,0.081675164,0.0008748318,-0.054236095,-0.041164692,0.02329239,-0.044403464,-0.06352477,0.008342653,0.08716705,0.025189815,-0.10177712,0.016647944,0.046500094,0.086628,-0.032197814,-0.03615565,-0.04562219,0.0964859,0.030335246,0.029648203,0.043702602,0.015499366,0.00457516,-0.03782742,0.033516046,-0.020395955,-0.027615702,0.016351331,-0.08155418,-0.02236042,0.08491775,-0.06321541,0.024159092,0.002940529,0.05807478,0.08172702,0.027207574,0.08504038,-0.13063522,2.7926107e-33,0.10043222,0.122944795,0.01365317,-0.003802897,0.008627827,-0.086538404,-0.093388416,0.01402763,0.026173398,-0.045981083,0.039910365,-0.003532261,0.033849444,0.019026525,-0.04208331,0.01129325,-0.023273077,0.014066038,0.036968935,-0.02386059,-0.11576971,0.013794825,-0.0015993072,0.052275673,0.072442695,-0.041851465,-0.060819283,0.055952236,0.090777926,0.021604352,0.014675511,0.06590799,-0.027725743,0.050960176,0.056148663,-0.0027206237,0.020065796,-0.016024794,0.026658174,0.047595814,0.084369905,0.02946893,0.014060721,-0.027541451,-0.013419952,-0.08713306,-0.084009185,0.05825763,-0.05061064,0.02939647,-0.007594482,0.008075672,0.048161104,0.038028557,0.01758768,-0.029712081,-0.059574362,0.01007473,0.055496994,0.021481933,-0.012058229,-0.040511094,0.05496937,0.09932481,-0.006952718,0.03586217,-0.06821821,-0.027477825,-0.007537788,0.023336804,-0.040154308,0.0014014926,0.10299087,0.043443296,0.02210598,-0.13399194,0.0027149916,0.028151335,-0.0013504722,0.06943817,0.029700471,-0.007884571,-0.06806321,-0.069194645,-0.017571991,-0.04267342,0.06393559,-0.0813571,0.0068900734,-0.043678224,0.016460808,0.01100537,-0.023912547,0.028524568,0.009639261,-4.844315e-33,0.105893485,-0.10025564,-0.025676092,-0.04790112,-0.09246941,-0.009012558,0.13677211,-0.039667394,0.009803208,-0.035081893,0.041434415,0.008759206,-0.0013981364,-0.07781812,0.030158909,-0.002304117,0.0070167244,0.090537556,0.06581533,-0.005437223,-0.025231507,0.08693528,-0.06462425,0.05638092,0.08471201,0.0006324617,-0.076528355,-0.005539789,0.009958369,0.020784784,-0.0015601491,0.05844085,-0.063601956,-0.033624914,-0.040620215,0.10588936,-0.02542623,0.015411781,-0.046451062,0.024512442,-0.009828025,0.010281538,-0.036048416,0.007203244,0.05807164,-0.0018088731,-0.063870795,0.07468685,-0.011032432,-0.02919434,0.054665398,-0.019276785,-0.054011963,-0.0360874,-0.00719148,0.08267364,0.046225708,0.06279559,0.02361802,-0.0074251383,-0.050773855,-0.02850723,-0.019192133,0.010025551,-0.008268664,-0.008839906,-0.04668524,0.06427951,0.054298073,0.032272007,-0.07207271,0.039830476,0.10793175,0.09294842,-0.0016935117,0.011544592,-0.046310112,-0.07017256,-0.09210108,-0.06915564,-0.0654147,0.015900757,-0.019919228,-0.022881612,-0.04305717,-0.036132406,0.03465365,0.031549092,-0.09708346,0.007137399,0.014005287,-0.047827117,-0.107508264,0.08423231,0.046222765,-4.5746262e-08,0.108863875,-0.010603037,0.027500957,-0.06310449,-0.008552617,0.04112565,-0.019923508,-0.018832663,0.05923213,-0.10481175,-0.03828095,0.08892041,0.02164223,0.05116842,-0.019863205,0.0025788625,-0.03564557,0.025925623,-0.08144201,-0.03783135,-0.05937083,0.04539217,-0.058165006,-0.0017719499,-0.09458545,-0.027112009,0.07018081,0.09193695,-0.05675329,-0.08994143,-0.027170442,0.0072969864,-0.004634614,-0.056310702,0.061325453,0.0158895,0.05221627,-0.041725803,0.017321447,-0.0028175395,-0.0013035659,-0.033094797,-0.116871804,-0.026112434,-0.023349937,-0.009680895,-0.0024526722,0.0066721607,-0.06594903,0.026816752,0.031361748,0.0061393557,-0.031322572,-0.058514915,0.008340015,-0.013469733,-0.027612984,-0.0059546814,-0.004348279,-0.007776425,0.026914762,0.022542993,0.08780921,-0.08430597 +2.3.1.258,"N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis. It may also play a role in membrane targeting and gene silencing. NatE is found in all eukaryotic organisms and plays an important role in chromosome resolution and segregation. It specifically targets N-terminal L-methionine residues attached to Lys, Val, Ala, Tyr, Phe, Leu, Ser, and Thr. There is some substrate overlap with EC 2.3.1.256, N-terminal methionine Nalpha-acetyltransferase NatC. In addition, the acetylation of Met followed by small residues such as Ser, Thr, Ala, or Val suggests a kinetic competition between NatE and EC 3.4.11.18, methionyl aminopeptidase. The enzyme also has the activity of EC 2.3.1.48, histone acetyltransferase, and autoacetylates several of its own lysine residues.",384,0.99999994,-0.07917338,-0.06041394,-0.055138532,-0.027911114,0.090354,0.031673998,-0.02633025,0.019313416,0.061900392,-0.012859573,-0.0033943297,-0.037087493,-0.094539754,0.078898236,-0.03519883,-0.030719798,-0.08530463,0.0147664435,-0.038754534,-0.055579852,0.046913307,0.06816976,-0.04138011,-0.045667563,0.035665948,-0.006093786,0.014482557,-0.012050397,0.01431397,-0.11625835,0.010030629,-0.01624382,-0.0029750096,-0.0091464,0.030662896,0.03443538,-0.07559251,-0.029515898,0.055628885,-0.016045682,0.08744804,0.0077180634,0.009631434,-0.042623922,0.06698456,-0.015926555,-0.09745296,0.019145813,0.070537746,-0.044414923,-0.01768633,-0.05103587,-0.000729728,0.09606958,0.02882887,0.04540507,-0.033048972,-0.033597406,0.016127454,0.024318054,0.005180075,-0.011443819,0.02293304,-0.04936689,0.0748088,-0.041003156,0.06465803,-0.08921903,0.08436273,0.01989332,-0.010148096,-0.020053303,-0.05811743,0.035067346,0.015326468,0.013385377,-0.02751309,0.03389266,0.008951158,0.0043659247,0.04269244,0.0452617,0.004947571,0.06462013,0.023463583,0.011409314,-0.029366298,-0.012419476,0.078151464,-0.024805754,-0.06718332,-0.0045039663,0.031143738,-0.012814477,-0.049678326,0.0043632654,0.04282706,0.040243533,-0.04160537,0.043122202,0.026400495,0.06627246,-0.04988973,-0.037523277,-0.05331015,0.06747444,0.057890672,0.0093139885,0.051497538,0.028158154,0.040596023,-0.070340775,0.090931565,0.020567136,-0.025436869,0.026850374,-0.014342659,-0.042262066,0.099494286,-0.0062571154,0.008926843,-0.04746975,0.04991912,0.032533895,0.026364809,0.10908285,-0.10911346,1.8236039e-33,0.06302133,0.016284483,-0.01739481,0.00087686564,0.07483792,-0.055607177,-0.07362478,-0.0076508527,-0.038057443,-0.10245762,-0.09151974,-0.019487647,0.016736075,0.008210198,-0.023798525,0.031184131,0.0021582467,0.015030534,-0.028633967,0.022530086,-0.04234043,-0.048055228,-0.052639537,0.062495913,0.03692388,-0.032492593,-0.09884096,0.0038817753,0.045899466,0.028567633,-0.019372176,0.0160991,-0.051077653,0.1042826,-0.009798512,-0.010237968,-0.032572165,-0.042364825,0.04097464,0.054900415,0.025241325,0.09245367,0.023033265,0.0094948085,0.005689076,-0.0445779,-0.044522356,0.09059151,0.010872666,0.03746311,0.033239152,-0.041611146,0.060448255,-0.026440032,-0.0036789672,-0.05137402,-0.06210922,-0.007370811,0.039254375,0.07183593,-0.0052679195,-0.020655004,0.0032835433,0.08462177,-0.010580825,0.039617643,-0.06560904,-0.0064793853,0.0475874,0.03314865,-0.050427273,0.015798593,0.11849515,0.04837743,0.07058815,-0.08563152,0.013687373,0.08689854,-0.0056322357,0.08279279,0.021677257,0.03147684,-0.021070339,-0.064192116,-0.09705893,-0.06004653,0.08416458,-0.037020322,-0.014165575,-0.020541824,0.071197666,-0.029906277,-0.07628869,0.029286329,-0.01935134,-2.1977149e-33,0.108752094,-0.03218033,-0.02855008,-0.0910603,-0.107150525,0.0027043677,0.040786725,-0.07646885,0.043604348,-0.084093966,0.06949999,-0.010867608,0.03935881,-0.025580676,0.07623871,-0.08360448,-0.010755552,0.117371276,-0.0054664775,-0.008866919,0.037551757,0.033190645,-0.072471134,0.028104156,0.079523705,-0.05801706,-0.042052973,0.029823897,-0.03338254,0.05969872,-0.03631257,0.03644834,-0.10089366,-0.026273925,0.003838063,0.10452851,0.023957346,-0.002032857,-0.031992514,-0.033460934,0.0736394,0.035758223,-0.016398082,0.031566616,0.04918355,0.040844094,0.015294065,0.039420687,-0.009706021,-0.05269363,0.042315096,-0.029886551,-0.01232837,0.020052772,-0.03842695,0.09334194,0.01695074,0.06544424,0.004862916,-0.018317493,0.029525746,-0.07058276,-0.020104164,-0.0013621312,-0.013614977,-0.0008422567,-0.015797732,0.09324035,0.11014754,0.022984577,-0.040912777,0.0008652696,0.16365281,0.05009729,-0.050716843,-0.023870606,-0.08848139,-0.08515005,-0.036559127,-0.07042834,-0.08812957,0.0039363373,-0.06270049,-0.050272442,-0.019120827,-0.01443653,0.048850056,0.10706219,-0.065977275,0.041402888,-0.017433548,-0.075409204,-0.124616995,0.051493634,0.015427533,-5.2207398e-08,0.17369199,0.027446043,-0.03895332,0.012905769,-0.012601692,0.036866568,0.0144576775,0.0052585024,0.03858319,-0.0018692854,-0.014668369,0.120446056,-0.014598029,0.011650098,0.010656659,0.04035309,-0.0219345,0.04607056,-0.06303808,0.010168083,-0.02925033,-0.026014687,-0.0590698,-0.00093730335,-0.04646496,-0.07497865,0.07356737,0.10198594,-0.055821814,-0.11031975,-0.03447944,-0.023378117,0.0040755407,-0.034754403,0.018438935,-0.013182638,-0.0518482,-0.01208315,0.019262781,0.03905273,0.024852358,-0.05395177,-0.059953038,0.011204426,-0.0020315317,-0.025302423,0.012413159,-0.008563511,-0.025215331,-0.010524838,0.03396619,-0.037053265,0.00046252503,-0.039881576,-0.07561922,-0.037847623,-0.025996186,-0.014857448,0.0002539945,-0.01786497,0.015135688,0.031820968,0.11323624,-0.041319057 +2.3.1.259,"N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis. NatF is found only in higher eukaryotes, and is absent from yeast. Unlike other Nat systems the enzyme is located in the Golgi apparatus. It faces the cytosolic side of intracellular membranes, and specifically acetylates transmembrane proteins whose N termini face the cytosol. NatF targets N-terminal L-methionine residues attached to Lys, Ser, Val, Leu, Gln, Ile, Tyr and Thr residues.",384,1.0000001,-0.042711794,-0.06847088,-0.101662576,-0.0107337795,0.087066375,0.049975976,-0.00893019,0.031518176,0.05882453,-0.033030946,0.0012870954,0.02650387,-0.14403176,0.06259396,-0.038447965,-0.055333663,-0.09395832,-0.011386621,0.033159077,-0.09947389,0.052106358,0.08914257,-0.04514919,-0.0435876,0.025891302,-0.07985366,0.039825696,-0.04922236,0.018313155,-0.10074512,-0.022921493,-0.0099266255,-0.021312116,-0.003444915,0.020101441,0.06713218,-0.016331991,-0.05162532,0.038371995,-0.04617439,0.078161225,0.009518315,0.020784184,-0.021685088,0.013372325,0.057368238,-0.042748258,-0.02095448,0.0921309,-0.01883199,-0.027846893,-0.0045015183,-0.056526914,0.0712684,0.003195636,0.07926291,-0.0122773405,-0.08779371,-0.008745855,0.06594684,0.03743578,-0.02141641,0.0091064675,0.019394767,0.052088782,0.010021762,0.02546995,-0.036346614,0.024035946,0.0013345473,-0.045993157,-0.06190559,-0.07898398,0.0039827703,0.0024615342,0.009757879,-0.026287923,0.009372938,-0.0009066482,0.041410394,0.0795431,0.057071052,0.07057648,0.09816516,-0.0029639776,-0.016505836,-0.026922228,0.032916136,0.09570221,0.0017562221,-0.026920816,0.012967185,0.026734767,0.034140933,-0.07464522,-0.025772886,0.06298773,-0.014133692,-0.06371366,-0.013398508,0.040644757,0.056652896,0.06790737,-0.07653992,-0.069975615,0.10502069,0.030477284,0.028691346,0.06744127,0.06059678,-0.02828124,-0.018171903,0.09222156,-0.045248542,-0.046041016,-0.024935488,-0.0054438706,-0.045884013,0.03792811,-0.07405322,0.020385476,-0.023650676,0.030979553,0.0580387,-0.005399304,0.08481425,-0.10999528,2.9758167e-33,0.03612185,0.0537109,0.031967394,0.031999316,0.030130107,-0.063323006,0.0060855816,-0.006210089,-0.023593025,-0.015411351,-0.0071656657,-0.011260585,0.0040384005,0.056537483,-0.06623284,-0.006025023,-0.032101694,-0.0021756452,0.034075275,0.026630148,-0.037171807,0.010950999,-0.06719446,0.015824916,0.090776004,-0.020617435,-0.03957796,0.00072287617,0.0147036165,-0.017812409,0.033809744,-0.0012472536,-0.034492645,0.03930397,0.071495384,-0.016214311,0.0061275843,-0.011466872,0.005271968,0.026485007,0.007406461,0.06085916,-0.023421984,0.04500775,0.01127329,-0.08120785,-0.09132134,0.07290683,-0.02547813,0.059642363,-0.0060191243,-0.0024649801,0.031095589,0.05161046,0.012711623,-0.0062794015,-0.07836509,0.063096546,0.011967257,0.01901733,0.033205774,-0.011411928,-0.012129873,0.05761536,0.004757304,0.09585495,-0.046308048,-0.09481153,0.038786143,0.018412171,-0.0836265,0.029075028,0.08650185,0.07879194,0.020330725,-0.08800792,-0.025899515,0.056099627,0.025411637,0.040505555,-0.025327072,-0.012114687,-0.016489882,0.00022165487,-0.03280859,-0.055214137,0.036245313,-0.046869934,-0.0147027355,-0.06738214,0.08943765,-0.027662372,-0.063425384,0.08931684,-0.027334815,-3.3847438e-33,0.11821198,-0.13668053,-0.04131711,-0.08855827,-0.061207976,-0.030046538,0.077074826,-0.052692376,0.054941602,-0.027096312,0.030926459,0.024298344,0.023551855,-0.0118364105,0.051748242,-0.0801098,0.006651885,0.10345874,-0.0156162,0.010451869,-0.0058179554,0.09472507,-0.035070863,0.05293706,0.08046205,0.009151937,-0.03672046,0.033566352,-0.07462548,0.030091219,0.031811822,0.03455457,-0.055602875,-0.060876455,0.0055940975,0.08001283,-0.029968457,0.0076792534,-0.031443644,-0.027367156,0.04870045,0.030274613,-0.028321339,-0.032884896,0.030424697,0.004905679,-0.10660096,0.038206134,-0.01445318,-0.010344628,-0.0068940124,-0.0057318914,-0.040566366,0.004622643,-0.015864588,0.0900388,0.08125323,0.021531342,0.045142103,-0.036950767,0.00965921,-0.06684702,-0.026873909,-0.02527917,0.015800348,0.010357749,-0.053889878,0.054129686,0.06922146,0.010480924,-0.029094413,0.039151844,0.07942105,0.09370272,-0.073744975,-0.014268255,-0.057364307,-0.10310341,-0.061778255,-0.05156083,-0.07002534,-0.0071728593,-0.02887777,-0.024094628,0.0058077304,-0.013835328,0.06397063,0.05757081,-0.06270027,-0.0040766615,0.011318444,-0.10644029,-0.1483727,0.06999003,0.022218954,-4.4747782e-08,0.0949014,0.037993215,-0.010111472,-0.057316247,-0.0807687,0.05215021,0.059107058,0.015761668,0.012343829,-0.042959552,-0.012852097,0.11902676,0.0005853193,0.04781431,0.014621611,0.07410137,-0.06521935,0.0380835,-0.049346853,-0.043109555,0.00012989278,-0.019159548,-0.103766076,0.054601364,-0.048308488,-0.053484995,0.10800764,0.106658295,-0.035364933,-0.06580715,-0.030530127,0.020359041,0.01650463,0.006740634,0.013409229,0.05928078,-0.021090083,-0.024564343,-0.023047797,0.049290534,-0.035665095,-0.057839192,-0.058924615,-0.025970306,-0.038988207,-0.017404651,0.0356295,0.004214783,0.029292837,0.0017576647,0.06470617,-0.0065884953,-0.065371394,-0.03728193,-0.0071330406,-0.018094447,-0.041585147,0.025856469,0.015047226,0.015637692,-0.014143891,0.020988172,0.1640725,-0.065623626 +2.3.1.260,"The synthesis, in the bacterium Streptomyces rimosus, of the tetracycline antibiotics core skeleton requires a minimal polyketide synthase (PKS) consisting of a ketosynthase (KS), a chain length factor (CLF), and an acyl-carrier protein (ACP). Initiation involves an amide-containing starter unit that becomes the C-2 amide that is present in the tetracycline compounds. Following the initiation, the PKS catalyses the iterative condensation of 8 malonyl-CoA molecules to yield the polyketide backbone of tetracycline. Throughout the proccess, the nascent chain is attached to the OxyC acyl-carrier protein.",384,0.99999994,-0.05760333,0.00011434732,-0.12402592,-0.04193816,0.022741085,0.008879849,-0.0659408,0.091413796,0.15229648,-0.033970095,0.004724916,-0.04866076,0.049022578,0.047293924,-0.1249705,-0.0299253,-0.07322334,0.013767321,0.056261353,-0.041474547,0.01241446,0.067238696,0.023418443,-0.009671154,-0.0033133943,0.020062184,0.015969623,-0.017324543,-0.022468112,-0.048389684,0.047424853,0.025085881,0.032613453,-0.054172467,0.10649631,0.13618045,-0.031239033,-0.011828142,0.114043914,-0.03405883,0.035157606,-0.02237269,0.010076649,0.04459477,-0.017176481,0.040141035,0.0005797452,0.049894597,0.04345492,-0.025157377,0.0013678926,-0.04336148,-0.0914234,0.058709666,0.013542186,0.08221984,-0.04576949,0.029851934,0.041978568,-0.056390643,0.07139429,0.009089103,0.034141365,0.03651087,-0.023336628,-0.048575796,0.055944066,-0.041186288,0.00522908,0.03794005,-0.11634965,0.026990483,0.008087231,0.07091311,0.05777465,0.011728874,0.0062751533,-0.052295815,-0.10104145,-0.011220349,-0.004524872,0.0025429153,0.031398494,0.042593468,0.01920898,-0.06467444,0.07787263,0.0037400217,0.012457515,0.021411046,0.044605333,-0.015527528,0.01014557,-0.06063298,-0.0237831,-0.0046140016,0.010947721,0.01060631,-0.008406687,-0.01584802,-0.11206764,-0.03521016,0.038414564,-0.05501774,-0.038528513,-0.011975312,-0.02525585,0.026559336,0.060088776,-0.037628863,-0.041733466,0.007313965,0.006104789,-0.051081955,0.010202303,0.03600936,-0.009794011,-0.05635176,0.027725698,-0.0074223946,-0.016433675,-0.007804173,-0.013523369,0.011271532,-0.050843883,-0.010215502,-0.10172402,1.2351982e-33,0.039933,0.0745648,0.0770017,-0.03894234,0.0019507844,-0.05512322,0.0008476471,-0.058428444,-0.014342337,-0.002254267,-0.08276815,-0.12329041,0.030648394,0.039841175,0.0564246,-0.06561457,0.0025266777,0.03432718,-0.030822149,0.014019055,-0.01412711,0.048982404,-0.006396866,-0.0008862305,0.062104933,0.0332981,-0.017909743,0.022364179,0.04222317,-0.015389847,-0.066197746,0.039303944,-0.07928178,0.07103781,0.06629159,0.0060209907,-0.030351676,-0.05728935,0.065317,0.045992326,0.026944833,-0.017054774,-0.020252852,-0.058065243,0.038232427,-0.0003711192,-0.045983907,0.066564575,0.00011302583,0.06402883,0.037946843,0.003680162,0.023065468,0.023209294,-0.08842508,0.027895862,-0.089325875,-0.014514989,0.044941224,-0.0056900987,-0.0081587145,-0.0057849106,-0.029169999,0.0012564694,-0.021339096,0.053986613,-0.07605137,-0.01990424,-0.025452616,0.05934443,-0.05238414,0.049025506,0.034690425,0.038762044,0.065120555,0.045682047,-0.09587657,-0.029361634,0.11189319,0.0020383208,0.01260258,0.0050433218,0.0010319786,-0.070203744,-0.03032339,-0.040985905,-0.030779293,0.025055032,-0.009646376,0.07525134,-0.02440182,-0.09140391,-0.017518431,0.05523594,-0.035088893,-3.3017936e-33,0.15221104,-0.07342071,0.03055527,-0.06531853,-0.069957376,0.06138765,0.0039634756,-0.08652811,-0.024690961,-0.040084124,0.07532897,-0.002083561,-0.018235942,-0.047369096,-0.017983867,-0.02367099,0.036768924,0.06024739,-0.0040661604,-0.040005002,0.044049177,-0.04657063,-0.040203992,-0.025953595,0.0006228906,0.020528417,-0.067538135,0.10355665,0.03480322,0.07788102,-0.026043875,-0.051743127,-0.025606759,0.015945993,-0.07899509,0.09936532,-0.12224062,-0.04835153,0.07448939,0.033046972,0.09080787,-0.012040991,0.02998078,0.05382213,0.058516543,0.020497942,-0.031915665,0.0044391095,0.013253207,-0.12894799,0.057833154,0.061672408,0.04673059,-0.029801162,-0.029493231,0.09645827,0.025019316,-0.025881942,0.033015694,-0.1206848,-0.053405885,-0.053381946,0.029870672,0.006155736,0.020364214,-0.0012379405,-0.0315515,0.05408977,0.028729582,-0.0018536096,0.031487677,0.014577805,0.011407962,-0.00521607,-0.010370524,-0.09257535,-0.060520966,-0.06025842,0.032764755,-0.048983887,-0.06300231,-0.003477243,0.008639241,-0.08720482,0.00645718,0.020722076,0.052337505,0.016126586,0.024620755,0.011873441,0.0014532087,0.03600937,0.036104757,0.12078685,0.11252902,-4.3615056e-08,0.055476584,-0.019392878,0.014769291,0.008034508,0.06255182,0.0069040745,0.007823599,-0.037995752,0.007314692,-0.06753229,-0.059264347,0.019488938,-0.009774152,0.02870803,-0.0038230151,0.05817057,-0.06614902,-0.04838663,0.017376168,-0.06850145,-0.13590798,0.009140005,-0.084812306,0.02446486,0.03381166,-0.0054459427,0.07159808,0.020258464,-0.03434911,0.03318608,0.012310861,0.03515674,-0.09325074,0.0002922413,-0.022988128,0.015650382,-0.05106623,-0.040630817,0.012850131,0.0058722803,0.028461067,0.07916216,-0.058575362,0.031170702,0.008729582,0.019899078,-0.021809377,-0.029246695,-0.10793461,-0.08118282,0.08826942,0.047908854,-0.059398517,0.005360807,-0.021685125,0.06969088,-0.015215214,-0.036126368,-0.08006436,-0.055943977,-0.06534559,-0.05196553,0.14836144,-0.027300056 +2.3.2.29,"The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-aspartate or L-glutamate residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. cf. EC 2.3.2.6, lysine/arginine leucyltransferase, and EC 2.3.2.8, arginyltransferase.",384,0.99999994,-0.039481584,-0.03264399,-0.032986842,-0.09074474,0.110317536,0.049613573,-0.045338474,0.06527539,0.046265665,-0.041804627,0.042393178,0.00017814233,-0.039303288,0.09724295,-0.058403958,0.054145195,-0.11209785,-0.011739386,0.0072522466,-0.01257065,0.07594205,0.110058,-0.11626892,-0.027688699,0.055181257,0.05941369,0.056641262,-0.08295301,0.027062345,-0.053190816,0.011640397,-0.062214453,0.054162897,-0.096775115,0.098022945,0.042011425,-0.0024972255,-0.08454469,0.102033585,0.01891674,0.024097845,0.07557957,-0.037412893,-0.049868256,0.035675306,0.047450397,0.011689756,0.0462214,-0.011092355,0.028532537,0.05396375,-0.033529952,0.0076978407,0.043275677,0.013662675,-0.021477917,-0.10593545,-0.07498337,-0.029193051,0.044336293,0.012872495,0.038465712,0.011397766,-0.03027202,0.075126365,-0.08209981,0.056238804,-0.07445332,0.023049256,0.009152498,-0.1083222,-0.02069742,-0.024652744,0.059225973,0.025613114,0.043389186,-0.016597416,0.0029003082,-0.0043176534,-0.056445893,0.0049223327,0.023001973,0.040695935,0.0715539,0.022186665,-0.08627058,-0.014945839,0.031006427,0.021814948,0.034023203,0.022065125,-0.07468533,0.01592348,0.00395131,-0.036636636,0.051104147,-0.056918498,-0.002469458,-0.010664676,-0.046745792,-0.052137416,0.028143845,0.017856799,-0.0996543,-0.017225921,0.032786623,0.020792354,0.086750455,0.037290413,-0.054432098,0.043073963,0.019770617,0.053178854,-0.01151485,0.036567047,0.04136884,-0.010175058,-0.036406994,-0.01880925,0.013818195,0.011572393,-0.051444605,-0.007782855,0.055974763,-0.04592363,0.1354025,-0.05906294,1.6920216e-33,0.038470812,-0.05459619,-0.019894047,-0.03122605,0.022863217,-0.014695658,-0.07295112,0.013372728,-0.027968626,-0.03874606,-0.019470688,-0.10309256,0.0150263235,-0.02086345,0.019074405,0.020534035,-0.01733622,0.015538377,0.034376062,0.016598497,0.0017651331,0.03309282,0.01983594,-0.020162202,0.07525982,0.084886394,0.013418075,0.0052295527,0.041464448,-0.008005867,0.033662718,-0.054286126,-0.08584364,-0.0011434092,0.018541712,-0.021200849,0.07515923,-0.06296393,0.012494501,0.042486433,0.0033977842,0.06471793,-0.08755651,0.02787431,0.048442837,-0.075361796,-0.019165965,0.08417034,-0.04021854,0.03215551,0.016386686,-0.06973068,0.032431446,-0.08662448,-0.029459022,0.007643656,-0.06271499,-0.014654701,-0.0024699143,-0.008930263,0.05576423,0.067270994,-0.053078502,0.0100834705,0.021428348,0.005338898,-0.04026225,-0.07635541,0.053688563,0.020558557,-0.07452705,-0.014100305,0.005344617,0.03986062,0.021500304,-0.12450097,-0.100570545,0.07716587,0.084331274,0.03550377,0.013056086,0.047606785,0.017887615,-0.07132036,0.022513017,-0.0438289,-0.00572887,-0.07612815,0.0010022125,-0.031182328,0.017351752,-0.022001145,-0.0088713765,0.09424328,-0.06346634,-2.109745e-33,0.06339837,-0.11084752,0.03089929,-0.0006533165,-0.094935596,0.05329718,-0.03305833,0.023389872,0.02617471,-0.024058333,0.06997929,-0.00733016,0.057904925,-0.034493387,0.09609863,-0.015774643,-0.033275243,0.04301322,-0.034362607,-0.05344998,-0.0026857418,0.0021013059,0.022376653,0.020205718,0.004988499,0.028276887,-0.092830084,0.043499473,0.039047245,0.0140456855,-0.0015160585,-0.020816015,-0.021626277,-0.018462831,-0.051802363,-0.0020457972,-0.033119854,0.02662443,0.0048956415,-0.029201403,0.055336483,0.0679491,0.023113638,0.035015695,0.0007796948,0.0139207365,-0.051106904,0.023053244,0.010778982,-0.110229455,0.014598211,-0.08221782,0.016042467,0.0032524173,-0.07444747,0.041914288,0.039168157,0.073249236,0.015152027,-0.02914424,-0.035216574,-0.059489626,0.03308899,0.06910282,0.12662378,0.042992048,0.0038004927,0.063716404,0.021349793,-0.07063069,0.008574231,-0.0013812166,0.025655793,0.04526785,0.0025230104,0.008177641,-0.11314297,-0.07840962,0.07220902,-0.041387983,-0.07206314,-0.04386041,-0.04615466,-0.04916908,0.020262277,-0.051553246,-0.015253008,0.09506036,0.051654674,0.04809502,-0.02064886,-0.0679998,-0.036684845,0.023269812,0.037504215,-4.0424798e-08,0.02020086,-0.023166578,-0.0022500178,-0.014688628,0.011535877,0.02949738,-0.047254372,0.027566891,0.09225585,-0.015631668,0.0413326,0.043582413,-0.05278838,0.012542556,0.028444521,0.045497183,0.06266382,0.02377002,0.013917613,0.011955689,-0.07477359,-0.028790379,-0.01986981,0.0459469,0.059584543,-0.06916908,0.024076996,0.1117278,0.018621448,-0.053315453,0.007072837,0.028623393,0.029565105,-0.005042991,-0.008732709,0.032182254,-0.026533157,-0.05138435,0.01490093,0.14516021,0.023151109,0.02851494,-0.07868524,-0.05913773,0.0087522175,0.00203646,0.07347595,0.0014752158,-0.15434954,-0.032325555,0.07570501,-0.1331597,-0.0072344635,-0.034160838,-0.076758094,-0.05222957,-0.014920423,-0.070256166,0.047462445,-0.033607986,-0.031293064,0.047807686,0.12429933,0.030809926 +2.3.3.17,"The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. Two forms are known - MAM1 catalyses only only the first two rounds of methionine chain elongation, while MAM3 catalyses all six cycles, up to formation of L-hexahomomethionine.",384,1.0,-0.057739772,-0.10286802,-0.0709083,0.053601235,0.052493688,0.0740435,-0.09696593,0.00827477,0.048982292,-0.02790629,0.12747093,-0.020329576,-0.013426706,-0.062125348,-0.012838538,0.078148246,-0.12643978,0.037908934,-0.009292123,-0.069040805,0.14233482,0.057497963,-0.04259684,0.0035290113,0.07400796,-0.06345991,-0.040112764,0.01695707,0.027707828,-0.11330977,-0.010877119,0.028711407,0.0979662,-0.02345564,0.051022556,0.07332883,-0.031336617,-0.041666526,0.054401573,-0.040218145,0.109014235,-0.024289258,0.05491344,-0.116440676,-0.05824415,-0.034659177,-0.0046938187,0.04310286,-0.04291781,-0.009943494,-0.021803582,-0.041366205,-0.08519474,-0.01608466,0.013468526,-0.03133708,-0.029127927,0.07399369,0.022141488,0.015335026,0.03681404,0.011587203,-0.028130196,-0.022081679,-0.03462589,-0.10079072,0.027277447,-0.049214028,0.06895431,0.05382975,-0.010796894,-0.052353982,-0.03819707,0.012165623,-0.002470186,0.06546098,-0.06188416,-0.021926653,0.008800326,0.008992558,0.04604328,0.026746176,0.033698734,0.047787756,0.003611264,0.0015140973,-0.070728116,0.03687984,0.056666393,-0.037949335,-0.017565165,-0.035182666,-0.07410879,0.005507914,-0.020705154,0.05394227,0.0363111,0.0036157905,-0.02275847,-0.024099978,0.026707571,0.06428642,-0.0173623,-0.03494104,-0.0054573477,0.043977182,-0.029028656,0.05240074,-0.0059959046,-0.0020651396,0.059885725,-0.037196532,0.03171937,-0.011601108,-0.03320452,0.06801881,0.05338788,-0.081527576,-0.051383696,0.030187998,-0.023084732,-0.023587657,0.040084895,-0.007401033,-0.06037205,-0.028919913,-0.09698872,6.413534e-33,0.064776786,0.027772592,-0.02905821,-0.01436867,0.043910496,-0.08300111,-0.07130783,-0.0014499979,-0.043310177,-0.05201014,-0.061444387,-0.037334625,0.015864048,-0.009679094,-0.07323306,-0.058862887,-0.013895617,-0.018759567,0.062363025,0.004773852,-0.064448096,-0.07099903,-0.08424371,0.00599051,-0.005983234,0.018671859,0.05306837,-0.043150138,0.0049445154,-0.023080135,-0.019957794,-0.00030605315,-0.061740022,0.00453265,0.020880515,0.010812225,-0.08125315,-0.08354418,0.008915636,0.040454436,-0.037444454,0.050559636,0.038441535,-0.07031107,-0.011323662,0.03253031,-0.055910874,0.07680906,0.075308226,0.092223175,0.06817274,0.016974589,0.11011315,-0.000360097,-0.04939456,0.042457096,-0.057386674,-0.027806763,0.016215488,0.08718786,-0.030344939,-0.048199877,-0.017990075,0.097076714,-0.039451864,0.05500115,-0.116853505,-0.00946929,0.04715402,0.14476135,0.013909484,-0.08984919,0.06692508,0.046993457,0.05267063,-0.018601958,-0.055140976,0.044561982,-0.015803413,0.033276685,0.07346518,0.02483475,-0.041024547,0.00036288155,-0.12370523,-0.0010664631,-0.030859089,-0.034561615,0.047180094,0.06826339,-0.019708222,-0.025588004,0.053642,0.057019185,-0.018812098,-6.416729e-33,0.05548801,-0.024011504,0.08726627,-0.06660419,-0.06855063,0.007851425,0.015980158,-0.020445095,0.011398681,0.033650286,0.070699774,0.037087888,0.012201871,-0.043108314,0.039385665,-0.008829278,0.09215815,0.023842243,0.08008799,0.056391813,0.032664135,0.03330662,-0.112855434,-0.033343446,0.055515297,-0.0068079927,-0.006198222,0.047074124,0.04513427,0.049589306,-0.03311997,-0.01270983,-0.008763245,-0.02152208,-0.067828536,0.083028905,-0.055469926,0.05681443,0.0070314747,0.031494442,0.051843856,0.028831976,0.046201415,0.06549495,0.07906113,0.039900083,0.003943933,0.011854269,-0.022162994,-0.11160248,-0.036571395,0.028973382,-0.03384204,0.00700054,0.007953252,0.09142301,0.04772801,-0.0025805077,-0.06230808,-0.021937275,-0.06367663,-0.06779608,-0.0006265208,-0.05428973,0.002788606,0.05456153,0.029097084,-0.018692512,-0.049056612,0.04320619,0.05879028,0.041799672,0.046526097,0.02774064,-0.027974574,-0.03014924,-0.100252576,-0.0431827,-0.09770917,-0.072972745,0.019610103,-0.021352498,-0.050946843,-0.073719166,-0.0062249075,-0.08386076,0.014233158,0.113947906,0.01567673,0.077860795,-0.05755452,-0.007863149,-0.0063628987,0.018465338,0.004869908,-4.1392244e-08,-0.021316616,-0.04777281,0.060238637,-0.023256376,-0.030222794,0.051856156,0.02462233,0.0069405753,0.051341005,-0.013657925,-0.006983347,0.04291678,0.015750004,0.002054021,0.022542385,0.032458868,-0.011342971,0.03222555,-0.013563235,0.03134433,-0.09713909,0.010318402,-0.102862,0.01916776,-0.033515517,-0.04249535,0.022860315,0.09786493,0.0009128427,-0.04813611,0.022536092,0.08791861,0.022172181,-0.030974925,-0.07013465,-0.05927513,-0.046110906,-0.039737675,0.017431678,-0.025760233,0.03945626,0.05504508,-0.019109823,0.03417698,0.00019958077,0.008489964,-0.0066363993,-0.03388036,-1.7182858e-05,0.07695494,0.016547836,-0.02539284,0.027271321,-0.07662254,-0.009551803,-0.035734087,0.034149755,-0.012982221,0.00020580343,-0.015997723,-0.021510955,-0.009220834,0.17686307,-0.07188111 +2.4.1.342,"The enzyme, found in Mycobacteria, can also use UDP-alpha-D-glucose with much lower catalytic efficiency.",384,1.0,-0.09279306,-0.025730554,-0.08371859,-0.008692121,0.0248652,-0.04229854,-0.012518466,0.09762679,-0.002086539,0.053304084,-0.055100635,0.03944327,-0.06243213,0.06246694,0.02116558,0.055199873,0.057423893,0.02173081,0.04246419,-0.040227298,0.043619677,0.011276904,0.02548618,-0.052170854,0.09714384,-0.00013401009,0.0922248,0.05011296,-0.037292756,-0.07296239,-0.008432532,-0.05649254,0.061627984,-0.080397256,0.06973224,0.11365196,-0.062473215,-0.06457106,0.042122085,-0.03908604,0.059332673,0.022921344,0.031641476,0.012870239,-0.0724874,-0.0004878479,-0.10955022,0.070595205,0.011226223,-0.028341662,-0.060831055,0.002663255,-0.07971194,-0.0295609,0.06233786,0.023001283,-0.027603483,-0.026332384,-0.022092056,-0.038779885,0.027915267,0.005564908,0.0558624,0.007479045,0.047706038,-0.054682624,0.011538719,-0.046775967,-0.0032325087,0.029608147,-0.07108756,-0.040584818,-0.056626365,0.07413781,-0.014859503,-0.03644119,0.01968065,-0.06320465,0.06398448,0.027685158,-0.02433594,0.008650462,-0.0004854057,0.0313179,-0.004352808,-0.0313727,0.10138686,-0.019149154,0.0074737333,0.0066978945,0.04280745,0.0053350157,-0.009611882,-0.03269229,-0.07570818,-0.039753336,0.059484545,0.03603336,0.008420228,-0.06458149,0.0027508351,0.03079697,-0.040199324,-0.08031148,-0.103985116,0.0029426867,-0.02074349,0.055391036,0.06014048,0.03846218,-0.014588353,0.05153414,0.031972077,0.028230919,-0.05365766,0.055522095,0.04708361,-0.0647003,-0.06243867,0.07446938,-0.01139314,-0.10980727,0.04656541,0.017592624,-0.07366521,0.09995489,-0.056019675,-3.138769e-33,-0.0015219738,-0.030146474,-0.05435546,-0.07569541,0.022100778,-0.0019513097,-0.09433854,0.032635435,-0.034680504,-0.042132042,-0.09666947,-0.05877511,0.034987178,0.09269386,-0.10094033,0.020308929,0.03471823,0.0021566655,0.04141061,0.057901565,0.03402884,0.03960634,0.052972514,0.042277623,0.050794825,0.050855417,-0.047939397,0.07496167,0.06838702,0.007023534,0.021994095,-0.10006266,-0.091998935,-0.005825549,0.018517278,0.020998761,-0.0750126,-0.06911513,0.034029473,0.05914003,0.0013089364,0.0040925485,0.046026126,-0.02661252,0.03908079,0.03787928,-0.05603075,0.0020188657,-0.03463346,0.019176425,0.057842087,-0.0073170294,-0.014109858,-0.07224842,0.022615751,-0.030766876,-0.021710748,0.046012823,0.026599891,0.044851277,-0.0030785145,0.09395117,-0.00091990136,0.0928971,-0.04253309,-0.039263763,-0.009403148,0.026652114,0.020895004,0.047033574,-0.017373774,0.011825547,0.057130095,-0.024096798,0.03352952,-0.08242413,-0.0012833439,-0.02338123,0.07235405,-0.07297698,0.00545233,-0.013240546,-0.029935293,-0.017260212,0.0020975464,-0.036132254,-0.11909049,-0.019406393,-0.018651392,-0.019109363,-0.030365417,-0.0148254335,-0.1200311,0.01590604,-0.033609945,-1.2328776e-33,0.11644573,-0.11885689,0.09478423,-0.050598998,-0.03401672,0.03293859,0.09572528,-0.1110267,0.07534864,-0.01136623,0.07603237,-0.017402383,-0.025499342,-0.01956182,0.07342645,0.030635502,-0.08540098,0.01535181,-0.081390314,-0.052118856,-0.03458636,0.12184066,-0.012202259,-0.00038997125,0.036598865,-0.031224469,-0.0703133,0.054556355,0.06959541,0.016500644,0.013187396,0.024900997,-0.02942469,-0.12134457,-0.04290659,0.05282554,-0.021292139,-0.0571174,-0.03829128,-0.026119668,-0.0035014278,0.067825325,0.009403243,0.009951947,-0.005706087,0.019975943,-0.064153306,-0.029985907,0.011303195,0.01329113,0.038750578,-0.02620288,-0.0103085665,-0.031484768,-0.040564522,0.051804874,0.05970861,-0.0014248486,-0.022341646,0.0087483,-0.03249575,-0.08290522,0.08468779,0.014192497,0.017393991,0.09257202,0.05655629,0.0147996275,0.08272777,-0.00787831,0.040493052,-0.013414375,-0.041399784,0.06814688,-0.037781972,0.051971503,-0.014779195,0.045468733,0.03127094,-0.010256908,-0.05555619,0.021090869,-0.0331657,-0.03462541,-0.016493693,-0.074928805,0.019735532,0.043664556,-0.029388921,0.054959245,-0.008950807,0.009863377,-0.0031245784,-0.021738878,0.07852109,-2.6569031e-08,0.04469984,-0.06908029,0.0715659,0.0039337194,0.051898275,0.006055723,-0.07035877,0.012592322,0.10539428,-0.017349187,-0.011340931,0.10037129,-0.04112752,-0.004609067,0.068958685,0.0019949179,-0.06729236,-0.0694304,-0.016972011,0.00027516746,-0.08153101,0.01926614,-0.124002226,0.02609973,0.016212044,-0.07438535,0.03002077,0.027032211,-0.0009960212,-0.024625741,-0.019397229,0.043876443,0.011015345,-0.028238151,-0.057585318,-0.0034196342,-0.011140091,-0.07590622,-0.034097686,0.06921745,0.0781712,-0.07174109,-0.019678358,-0.013442015,-0.06792969,0.04485581,-0.025629492,-0.020351632,-0.056640387,0.049041748,0.002840105,-0.011320751,-0.068864636,-0.021644166,0.014870402,0.054017134,-0.05694136,-0.040815704,-0.03979415,-0.035356183,0.054249246,0.007547052,0.14379354,-0.0759681 +2.5.1.135,"The enzyme, characterized from several Streptomyces strains, is involved in the biosynthesis of the antifungal agent validamycin A.",384,1.0,-0.037326828,0.007822168,-0.14707583,-0.0128959995,0.008588577,0.035214625,-0.09509944,0.052395724,0.0820948,-0.028573165,0.014051945,-0.017611535,0.057664268,0.03274759,-0.0784133,-0.01006982,-0.045919992,0.020317124,0.0044231936,-0.047476634,0.08929438,0.07045529,0.02054754,-0.019951075,0.064592026,-0.029876512,0.014697233,0.030396977,-0.033155106,-0.10027932,0.056546636,-0.00022730546,0.057104535,-0.059869803,0.10506437,0.11618715,-0.057829626,-0.04900308,0.15809403,0.030814951,-0.030748604,-0.07949676,-0.015777417,-0.0026137356,-0.072804734,0.009400291,-0.0061785057,0.039360326,0.0063541955,0.0029651087,-0.06559505,-0.04630665,-0.08013129,0.05585282,0.0713226,0.026663434,-0.016422745,-0.027157659,-0.038670976,-0.05858534,0.082801126,-0.037501734,-0.0023002792,0.026163494,-0.12259677,-0.023427749,-0.014488173,-0.09173679,0.03679962,-0.042237703,-0.09513676,0.0025632458,-0.008373684,0.0612774,0.015779443,0.014018305,-0.010368833,-0.028527236,-0.022480436,-0.031191736,0.073057786,-0.014117648,0.023108916,0.07735678,0.05921199,0.010270614,0.0366548,0.002336739,0.090336435,0.051755734,0.057225507,0.011054453,0.00875588,-0.0027400735,0.015598258,-0.007997129,-0.08253956,-0.004879367,0.010235866,-0.0020875346,-0.03104643,-0.013027574,-0.005258202,-0.017638078,0.015720079,0.0072268653,-0.021495152,0.037896905,0.033236757,-0.04564678,0.03932795,-0.039099168,0.029784666,-0.024800735,-0.015837755,0.06535926,0.14372158,-0.028381025,-0.091897234,-0.03706135,0.007235825,0.028640097,0.091103375,-0.008669802,-0.028931769,-0.027930696,-0.08475628,1.6180508e-34,-0.04118679,0.06810454,-0.016240103,-0.050429568,0.04071316,0.009199149,-0.07014849,-0.037148885,-0.028265411,-0.063360386,-0.08733395,-0.053346433,-0.02201854,0.032887354,0.051141974,-0.0080351345,0.02058455,0.052341267,-0.032627657,-0.007904655,0.050139934,0.016976751,-0.04726331,0.007040362,-0.016726526,0.04095643,0.015780171,0.036534663,0.08759647,-0.02940638,-0.029387858,-0.075929955,-0.027431827,-0.0029752306,0.070897296,-0.0009601372,-0.04764556,-0.033043552,0.053254437,0.029605877,-0.06389865,0.0039399383,0.013337846,-0.00049222907,0.054781333,-0.04123621,-0.0699469,0.06491955,0.083204694,0.069386624,0.05442263,-0.042554747,0.095083475,0.021550734,-0.07281577,0.029400062,-0.02785775,0.08831714,0.03586195,0.029380074,-0.008433965,0.0063366387,-0.006903597,0.038970437,0.023754295,-0.033664104,-0.01390806,-0.04461766,-0.011715936,0.045763202,-0.04648077,-0.031196529,0.005505026,0.03314533,0.00564149,-0.056005675,-0.09506843,0.0077185095,0.02987668,0.03441733,-0.04606628,-0.017884972,-0.06573118,-0.047391392,-0.09096668,0.032409955,-0.058952216,-0.07773518,0.037459515,0.0591967,-0.020774843,-0.055357803,-0.092556976,0.0493613,0.073751315,-2.6248772e-33,0.13440447,-0.08423366,0.06272916,0.0151866935,-0.05148325,0.08762488,-0.018537695,-0.0377321,-0.013048424,-0.0012793238,0.048952505,-0.04862422,-0.031037955,-0.054086592,-0.004933358,-0.02976947,0.01975023,0.07649627,-0.025060313,0.077284075,0.023246586,0.10013643,-0.046589762,0.028009687,0.051842034,0.035654265,0.01780732,0.0835152,-0.015087042,0.087502785,0.034269974,-0.04100957,-0.039264154,-0.051105734,-0.02496834,0.0801055,-0.015585561,-0.0052373083,0.09103522,0.0014447127,0.092449434,0.013828155,0.0050787297,0.033135783,-0.0069167116,0.049823843,-0.05121246,0.07709979,0.034243103,-0.1265026,-0.030464724,0.05366377,0.01226136,0.011027133,0.0028628286,-0.0036038307,-0.018378906,0.02057002,-0.009386167,-0.014218686,-0.034836277,-0.06340214,0.057924308,0.038497508,0.050808564,0.032176074,-0.023074254,0.0037777957,0.11823828,-0.039599683,0.036651805,0.014345901,-0.04549985,0.05528173,0.0059965136,-0.028682373,-0.0734339,-0.05179583,0.031118123,9.995077e-06,-0.022073127,-0.04961831,0.056016386,-0.04101079,-0.06325308,-0.081943296,0.06709681,0.01253062,-0.052244835,0.051069807,0.02607332,0.015316201,-0.010830016,-0.0060667787,0.027425421,-2.8720958e-08,0.060967565,-0.062472712,0.07490804,-0.07468778,-0.005152928,-0.036608107,-0.030480316,-0.06708237,0.025035318,-0.0075722802,-0.04519196,0.006432349,-0.007171401,-0.027484013,0.0047187614,-0.007513084,-0.07306186,0.04921065,0.0006518607,-0.009639529,-0.042720336,-0.034537062,-0.12556466,0.015732631,0.065206535,-0.013511267,0.0070571015,-0.003989705,-0.022184169,0.023679106,0.06317692,-0.011401592,3.899288e-05,-0.027390381,-0.06828031,0.035510596,-0.062042512,-0.033989087,0.06774627,0.00994627,0.033998027,-0.0072959196,-0.088856556,-0.023868596,-0.0820029,0.04079724,-0.01488072,-0.061757464,-0.10517273,-0.018878052,0.04882587,0.030472727,-0.0014831299,0.030884612,-0.08231644,-0.0037619688,0.016658762,-0.041552678,-0.051153757,-0.053204056,0.0010684407,0.0035045086,0.21829014,-0.075806886 +2.7.7.95,"The enzyme, found in certain mycobacteria, catalyses the activation of the methylated long-chain fatty acids, mycocerosic acids, by adenylation. The activated acids are transferred to the two hydroxyl groups of phthiocerols and phenolphthiocerols by PapA5, leading to formation of dimycocerosates (DIM) and dimycocerosyl triglycosyl phenolphthiocerol (PGL), respectively.",384,0.99999994,-0.066584356,-0.037882652,-0.0523458,0.021761598,0.0155110415,0.027373202,-0.02961012,0.03334229,0.028846161,-0.009183281,0.01660951,-0.074741244,-0.050431676,-0.026584132,-0.0006556333,0.038293045,-0.02539907,0.058342468,-0.034901857,-0.06627343,0.08760981,0.07403607,0.0052867956,-0.013401949,0.0008739075,0.0037602682,0.059266414,0.029653488,-0.013535331,-0.09462443,-0.020992972,-0.021566058,0.052716423,-0.034229808,0.038015403,0.118253306,-0.008785499,-0.11148293,0.06881627,-0.017021164,0.10919856,-0.059786435,0.008943999,-0.009800422,-0.059694782,-0.0111912,-0.08759428,0.054007366,0.0031106987,-0.049461696,-0.09036378,-0.07842129,-0.05683943,-0.007993417,-0.01974687,0.023242082,0.01293692,-0.004944462,0.014086292,0.028592762,0.047494918,-0.019813001,-0.0016880257,0.060906038,-0.08789857,-0.060514517,0.022854388,-0.0653293,0.042042743,-0.027857745,-0.105345875,-0.0058791544,0.01188296,0.053488277,0.0051546195,-0.045210157,-0.009080322,-0.052515112,0.048304867,-0.025918592,0.0020939368,0.017980324,-0.059558537,0.006964497,0.0048740837,-0.017845066,0.07972086,0.004164648,0.022537649,0.041534767,0.10684897,-0.066516355,-0.02481007,-0.04318378,-0.077070594,-0.025153242,0.07663698,-0.05351937,0.043019082,-0.03471192,0.024637196,-0.068833865,-0.06349128,-0.05043368,-0.06591389,0.057271503,-0.0758497,0.02624447,0.07713995,0.0545045,-0.03315715,0.061369058,0.0062729293,-0.013345889,-0.046961535,0.076955244,0.05942556,-0.06763775,-0.072161466,-0.040747695,-0.017069208,-0.11959343,0.046506938,-0.008840869,-0.13338014,-0.020965144,-0.08917726,4.925066e-33,0.0393723,0.008508299,0.008152653,0.0012861417,0.01354596,-0.052676465,-0.061007034,0.036040124,-0.06520205,-0.08305488,-0.013895939,-0.009530142,0.00677493,0.08778386,-0.07391768,0.041041255,-0.026689552,0.04690046,0.08089093,0.0022289907,-0.02337672,0.02161854,0.038635705,-0.028427584,0.007891041,0.106086046,-0.055333454,-0.018518072,0.018524235,0.005632768,0.033110254,-0.075221255,-0.055273887,0.018248495,0.070071876,0.08138331,-0.009581379,-0.08011831,0.07160135,0.034229625,-0.004048991,-0.045683667,0.025807582,-0.0043255654,-0.021341927,-0.017418092,-0.04591072,0.08428701,0.0015091785,0.059387155,0.027036885,-0.09600674,0.02743755,-0.027584651,-0.060074635,-0.020032216,-0.051461436,-0.030289289,-0.024054797,0.039430417,0.09320528,0.0752078,-0.035255507,0.08070299,-0.039291248,-0.05932904,-0.098883316,0.006872582,0.025933133,0.059334148,0.03798414,0.013300341,0.039236806,-0.005734492,0.03525012,-0.028797112,-0.063720666,-0.022385867,-0.038235463,0.053599257,0.09361929,0.007112867,0.0044722836,-0.053748976,-0.052450076,0.013694451,-0.052696083,-0.017723387,-0.011434758,-0.0028591147,-0.0737851,-0.06437911,0.03339423,0.041407615,-0.0084359795,-7.725586e-33,0.14727387,-0.07267396,0.0969516,-0.07715735,-0.008167714,-0.03334942,0.050923545,0.00069479685,-0.015881205,0.007794417,0.06279074,0.0055611636,0.003930016,-0.038194608,0.031762347,-0.0068161306,-0.02858327,0.021203555,-0.07803131,-0.04713994,0.0058628,0.020148588,-0.027727228,0.053967625,0.010244106,-0.031700466,-0.06306289,0.0510359,-0.008882452,0.10527475,0.0090668695,-0.026295792,-0.07924039,-0.046007894,0.02321171,0.016987784,-0.072075404,-0.007913004,0.038952876,0.0061695995,-0.0051519396,0.048150502,-0.0152771585,-0.031327095,-0.0147597585,0.027019145,-0.039500322,0.0006120234,0.035592895,-0.06488777,0.007067346,0.036301486,-0.009736219,0.061246034,-0.0065698014,0.10949335,0.022768432,0.004496139,0.0020490908,-0.11385818,-0.11252498,-0.06395511,0.040485747,-0.017926928,0.065875925,0.10535567,0.079127096,0.0026161978,0.055023205,-0.009840108,0.038927637,0.06994343,-0.03479559,-0.0051682927,-0.103570946,-0.03790118,-0.051996138,-0.013129838,-0.060652897,0.016864855,0.07696127,-0.035875827,0.007965263,-0.13015842,-0.030507732,-0.04131213,0.0398926,0.09545058,-0.032421213,0.050629593,-0.018067613,0.051812787,-0.017572977,-0.005159925,0.037570804,-4.1816286e-08,-0.00076753326,-0.0638954,0.018897092,-0.028529756,0.004304758,0.039276723,-0.0182561,0.024397185,0.089315884,-0.0032258742,-0.02341893,0.07595402,0.048015602,0.012131119,0.061664842,0.017923571,-0.077496625,-0.0065228883,0.050040234,-0.035554968,-0.07331522,-0.027808636,-0.0055977004,0.059771754,0.025054304,-0.050584458,0.053471096,0.08174692,0.009244727,0.054472025,0.03485489,0.057293423,-0.03550772,-0.011898015,0.03761249,0.026225654,-0.05485235,-0.034749914,-0.056730602,0.063683994,0.0507785,0.056799546,-0.09116343,0.03353476,0.016782844,-0.00023381902,-0.031497974,0.015973043,0.016390443,0.08964,0.019520266,0.020635633,-0.04275633,0.018925153,-0.06977917,-0.02092749,-0.012099886,-0.008566703,-0.07152375,0.008032688,0.0459043,0.06005211,0.18783852,-0.040362645 +2.7.7.96,"The human enzyme produces ATP in nuclei in situations of high energy demand, such as chromatin remodeling. The reaction is dependent on the presence of diphosphate. In its absence the enzyme catalyses the reaction of EC 3.6.1.13, ADP-ribose diphosphatase. cf. EC 2.7.7.35, ADP ribose phosphorylase.",384,0.99999994,-0.033208583,0.030782554,-0.009588569,-0.0043282453,-0.01661829,0.0065472648,0.0046504103,-0.0112780575,0.023700379,0.05396557,-0.008183694,-0.018622559,-0.101032995,-0.007024286,-0.008999081,-0.031041425,-0.039896015,0.006085555,0.05953344,-0.047854744,0.085840486,-0.0005259389,0.013136759,-0.029438645,0.033827152,-0.029928686,0.07639299,0.023661988,-0.019868465,-0.055455975,-0.071158715,-0.059181135,0.050865512,-0.07308974,0.06691135,0.12986404,-0.06763987,-0.023753166,-0.022487642,0.05285665,0.07146761,0.014053713,-0.054599736,0.036432724,-0.057878092,-0.04930966,0.010395214,0.04555856,0.024237074,0.0051146345,-0.046455063,0.025503969,0.0025679548,-0.0862784,0.044489454,0.008853688,0.0050904597,-0.014957301,0.009660697,-0.05797442,-0.0544521,-0.05041717,-0.032028943,-0.013101646,0.15908116,-0.073399104,0.052970655,-0.008187992,0.022187488,0.023990091,-0.03398168,-0.039532546,-0.035012364,-0.0069279866,-0.02720585,-0.013266493,-0.024730548,-0.07559765,0.049143787,-0.0004686984,0.03162357,-0.07364787,-0.0629049,-0.053323817,0.03347077,-0.0048201946,-0.00698182,0.04355504,0.03047004,0.04766606,-0.038618967,-0.029221274,0.02012751,-0.027127376,-0.08658714,0.079070106,0.023185592,0.06367858,-0.0016107812,-0.032168265,0.057974733,0.12798199,-0.017516684,-0.0240223,0.03912297,0.09091427,-0.028090687,0.08726702,0.0030049034,0.111440316,0.015627261,0.011710324,-0.002369806,-0.019663233,0.0072096954,0.075113006,-0.012524503,-0.11249771,-0.05491608,-0.008336021,-0.0068750205,-0.040548693,0.0041554505,0.10899159,-0.0121754045,0.029012896,-0.06649981,1.7182813e-33,-0.009504884,-0.028607462,0.043059994,-0.012495056,-0.032980315,0.007732966,-0.069104426,0.0068835886,-0.038995434,-0.050834917,-0.0443142,-0.08023796,0.11205949,0.010385364,-0.06158246,-0.08608101,-0.016518222,0.06287824,0.06274623,0.027772285,-0.06760011,-0.009118974,-0.026489746,0.04970847,-0.004326706,0.018447235,-0.06523651,0.037181303,0.036644176,-0.013933347,0.0363635,-0.045616,-0.09330039,-0.010027342,0.009152753,-0.041739684,-0.04767748,-0.029421013,0.034107942,0.031760555,-0.0337353,-0.0122168595,0.057398044,-0.04752953,0.03788116,-0.050653294,-0.0033222726,0.06030861,-0.016110443,0.02991382,0.0692704,-0.050847974,0.1400405,-0.049304448,-0.017485922,0.009683213,-0.03101397,-0.014752072,0.053539272,0.096274175,0.019276222,0.04096093,-0.04478585,0.08313014,0.003442734,0.057314266,-0.052128114,-0.11847766,0.005575119,0.10655538,-0.024203029,-0.012666992,0.06389591,-0.014366298,0.012984953,0.05462311,-0.04555703,0.0025976992,-0.10021311,0.057778142,0.015595271,-0.056632947,-0.015594813,-0.022703933,-0.01555548,-0.002674986,-0.0050818645,-0.09262937,0.052344672,0.06485567,0.0954107,-0.04816343,-0.07287989,0.028232671,0.034588553,-2.91692e-33,0.07272654,-0.033605542,0.017412944,-0.15228313,-0.06564861,0.017066492,0.054400858,-0.0638159,-0.054190155,-0.03742518,0.02164111,-0.079084285,-0.016549151,-0.08500937,-0.024355652,0.013612721,-0.0064332113,0.06855272,0.03659897,0.029085869,-0.0119254105,0.12046192,0.013052698,0.07052504,0.015536302,-0.01828135,-0.009312907,0.028784072,0.051452775,-0.023371058,-0.04779044,-0.010510288,-0.04152302,0.022552911,0.0056012715,0.036801916,-0.039609004,0.06818165,0.07984769,0.084070235,0.008866414,0.11780572,0.022757916,0.04228458,0.045479525,0.05481108,-0.005573677,0.028379695,-0.08600442,-0.06021374,0.024520481,0.008435093,-0.0062893913,0.012606269,0.0052455296,0.02056596,0.0034172197,0.025455413,0.08958908,-0.022294013,-0.01294771,-0.06220294,0.03446208,-0.012708722,0.030371204,0.049150754,-0.05426279,0.021624226,-0.045097493,0.04100221,0.009452598,0.0032942954,0.011108569,0.0021399127,0.036699697,0.04554423,-0.059206888,-0.003335415,-0.015344836,-0.07513315,-0.027720168,0.073208615,-0.06700256,-0.028609503,-0.02830114,-0.051708248,-0.016475076,0.03998531,-0.032568026,0.02641016,-0.04069767,-0.05097726,-0.03615901,0.054176357,0.06655153,-3.8204515e-08,0.041985516,0.03162071,0.08703474,-0.049120106,0.073478825,0.046518933,0.03776071,-0.0018357625,0.09780813,0.0107268505,-0.03179953,0.04992681,0.06965107,-0.0030985011,0.07839585,0.02152177,-0.06296764,0.0324101,-0.053295955,-0.07572428,0.022542007,0.016120436,-0.15017557,0.1632675,-0.012091556,0.009549609,0.023257,0.00865023,-0.0031623573,-0.0676548,0.029248878,0.019134872,0.0221953,-0.035108477,-0.02865676,0.0013629947,-0.017025188,-0.007714541,-0.047007617,0.010487673,-0.09012803,-0.05333202,-0.064475246,0.0030589201,-0.041762933,0.03641028,-0.0040894505,0.015160525,0.00068713864,0.0041509205,0.025881218,-0.023443328,-0.014962262,-0.1302273,-0.058608506,-0.06308872,-0.057739045,-0.053143192,-0.012684354,-0.04908272,0.119983025,0.036791813,0.11882045,-0.068524875 +2.7.7.97,"The enzyme, characterized from the bacteria Streptomyces anulatus and Streptosporangium sibiricum, activates 3-hydroxy-4-methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein.",384,0.99999994,-0.035742294,-0.044490613,-0.15190808,-0.029926924,-0.025949499,0.0117357215,0.022750022,0.053544004,0.058626737,-0.00040263342,0.03626921,-0.033116277,0.024428012,0.08533039,-0.02617472,0.07998111,-0.041073564,-0.013619226,0.097612105,-0.047421347,0.027631985,0.02806228,0.005020254,-0.0067394143,0.049179383,-0.030911868,-0.02465578,0.029827759,-0.04253352,-0.08677253,0.064638466,-0.016317692,0.08326509,-0.044090137,0.08500976,0.12739664,-0.08078913,-0.031809773,0.07581533,0.022450764,0.021122804,-0.043395523,0.025058981,0.07299473,-0.08900627,0.022082273,0.008816803,0.1047365,0.048383668,-0.013046394,-0.055158533,-0.07164562,-0.045126237,0.033876684,-0.0013227775,0.010523768,-0.054860003,-0.023819922,-0.0064314133,-0.010204964,0.06504981,0.021916809,0.04524106,-0.0031724016,-0.06791101,-0.019246796,0.038578562,-0.10575391,0.055818073,0.021163577,-0.06806568,-0.040013857,0.014547168,0.050924912,0.007238802,-0.055322483,-0.023951668,-0.00036713883,0.0008457222,-0.041533154,0.026326029,0.029774658,0.05699916,0.06960351,0.058625378,0.020133605,0.030845331,0.0023805122,0.03136938,0.0077019213,0.035898373,-0.04282439,-0.039951436,-0.008196336,-0.07277036,-0.027336443,-0.046504848,-0.061212473,0.029144522,-0.01248725,-0.012176165,0.01699941,-0.025481768,0.0026986373,-0.00577209,0.004285765,-0.051984664,0.0641465,-0.006646097,-0.028769989,-0.07019607,0.009297418,0.020354975,-0.051205795,-0.022509823,0.098790936,0.061773945,-0.06384251,-0.038500275,-0.02965916,-0.027293375,0.036851127,-0.011232922,0.0071679316,-0.050984785,0.00037698602,-0.12886128,3.2159516e-33,0.009291849,0.05829394,0.007722933,0.037755884,-0.019073453,-0.01649651,-0.050921507,-0.013438227,-0.032559425,-0.039676044,-0.10565644,-0.11100239,0.041903157,0.09775113,0.0392814,-0.0428509,-0.041940037,0.025334448,0.053371623,0.0038432316,-0.009752138,0.030247059,-0.076413706,-0.024096554,0.035112355,0.095236905,-0.0022697116,0.048545618,0.11066734,-0.021803472,-0.040875223,-0.051419318,-0.09911152,-0.018774332,0.036489297,-0.03139305,-0.069943026,-0.04082007,0.0613456,0.0617385,-0.06840995,0.04277678,-0.016331136,-0.032975297,0.033580564,0.0103044305,-0.034986567,0.075666666,0.07193718,0.03920881,0.1062592,-0.08511007,0.10062155,-0.040007938,-0.09485465,0.032072987,-0.062888205,0.023892814,-0.0013327325,-0.008253483,0.026860079,-0.057471566,-0.0134834545,0.025967035,0.014807844,0.0058618626,-0.0010116424,-0.078587696,0.018799562,0.08014661,-0.096787184,0.046385724,0.055590916,-0.021027895,-0.0030159529,0.022639811,-0.063703984,-0.02793917,0.05596244,0.031154092,-0.05697073,-0.047727965,0.013272468,-0.04596585,-0.029258559,-0.0055933236,0.0006344479,-0.06635739,0.00062449375,0.04548739,-0.0015621536,-0.089760594,-0.09817491,0.034763016,0.04534003,-4.5089947e-33,0.13637772,-0.028777806,0.05459093,-0.048866626,-0.076295964,0.118403494,0.023607425,-0.023757637,-0.0544235,0.011150893,0.04920136,0.031130236,-0.026667058,-0.054407794,0.02968463,-0.04573968,-0.0096629225,0.03419746,-0.03143767,0.027529983,0.01299202,0.06187978,-0.045436952,-0.01429702,-0.0048793955,0.014712018,-0.008334855,0.05794698,0.04218427,0.048442,-0.02174622,-0.05373761,-0.05833183,-0.050398957,-0.012999544,0.09932317,-0.037349563,0.054151498,0.02635713,-0.06417373,0.09750527,0.021865133,-0.012047319,0.12276781,-0.0012430255,0.08802785,-0.034460805,0.0700437,0.012039227,-0.08876079,-0.021973647,-0.018826993,0.04971754,-0.028092183,-0.015648946,0.035876807,0.012143189,-0.06582029,-0.050160497,-0.023126816,-0.05901231,-0.040929228,0.052416608,-0.029802095,0.008736855,0.042955305,-0.01752229,0.015335853,0.07421539,-0.022155263,0.026903354,0.04227549,-0.03828319,0.027148347,-0.01096681,-0.037808098,-0.061583187,-0.054951902,-0.005037274,0.005526176,0.03362897,-0.017416675,0.03347962,-0.025185242,0.01710872,0.003912121,0.04014965,0.04568736,0.033025403,0.01905183,0.021094605,0.09616216,-0.0130757755,0.011441729,-0.029983602,-3.866623e-08,0.042952184,-0.005755608,0.041268323,-0.10726917,-0.021892294,0.0352849,-0.055041805,-0.0047303415,0.0068802135,-0.03543236,-0.033415917,0.05338254,-0.010366107,0.010564265,0.002279932,0.018173434,-0.05655533,0.0030262189,-0.0038812875,-0.038064454,-0.12571007,0.009564118,-0.08670793,0.051833574,0.06386136,0.0074215094,0.054110847,0.022976927,0.030718818,0.06510864,0.071900025,0.01763385,-0.04765066,0.012937332,-0.057176534,0.0047281617,-0.09364131,-0.04941872,0.031244926,-0.010603606,0.101343654,0.04908438,-0.060551498,0.031699076,-0.02383377,0.060759734,-0.09973022,-0.06880008,-0.03869013,0.0068639647,0.063437775,0.010993605,-0.04278968,0.036603972,-0.1273446,0.014013348,-0.033877023,-0.080946386,-0.033676278,-0.079834245,0.024678096,-0.030786073,0.19345582,-0.0029794958 +2.7.8.43,"The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.",384,1.0,-0.04068853,-0.02918945,-0.021479836,-0.0601334,-0.011014141,0.047678333,-0.03421827,-0.002230999,0.050524194,0.030996038,0.06323858,-0.07471935,-0.0763958,-0.018925192,0.004457645,0.071841165,-0.046516024,-0.009599415,0.0115707815,-0.07283989,0.11255424,0.005478521,0.007964118,-0.0033221876,-0.008387737,0.09634279,0.044149294,0.014414219,0.028256256,-0.059275944,0.005830926,-0.028302377,0.02189837,-0.080155656,0.013843395,0.084702656,-0.015016517,-0.027405828,0.044100188,0.04520031,0.11308013,-0.03955869,-0.00556951,-0.019102326,-0.04530582,-0.078532316,0.013121159,0.03903623,0.095312946,0.008409052,-0.013264609,-0.08012333,0.006560021,0.017321656,0.009913096,-0.005521916,-0.08674155,0.062094066,-0.06668352,0.08165981,0.029418958,0.04060034,0.049527578,0.033251192,0.05243993,-0.06980047,0.0681396,-0.08648794,-0.010431802,-0.101507984,-0.07324566,-0.059861384,0.05843243,0.01667702,0.015673373,-0.03254633,-0.044439413,-0.020005358,-0.0045697275,-0.05616174,0.04042261,-0.06623243,-0.035866536,0.040480573,0.021615375,-0.01886698,-0.0071199383,-0.03749794,0.054345574,0.044913407,0.005477542,-0.04965447,0.0047795447,-0.023767304,0.0022364645,0.021362491,-0.003537673,0.0276436,-0.01970798,0.023189355,0.005207922,0.06086332,-0.09337996,-0.08506179,-0.040272027,-0.028576782,-0.009641495,-0.021410936,-0.06913822,0.0023489422,0.0064467113,0.0010383982,0.05314523,0.024835153,-0.06041668,0.10494653,-0.012857967,-0.048691515,0.0061778985,-0.03768901,-0.008232237,-0.029311014,0.10355262,0.10133762,-0.024812512,0.08792829,-0.1139939,3.3884234e-33,0.038923737,0.035568014,0.0037266037,0.01696365,-0.047045734,-0.0027216657,-0.08079009,0.039176967,-0.08419807,-0.01984268,-0.07229674,-0.07174003,0.11383798,0.09171939,0.023990814,-0.039751273,0.016094772,0.017921146,0.14614102,-0.000240521,0.011733043,0.021307023,-0.020496568,0.073502615,-0.0050915806,0.07481445,0.0044072,-0.026304837,0.045260504,0.027442109,-0.036027223,-0.021911442,-0.09604549,-0.08051849,0.02213405,-0.02447497,-0.039287273,-0.057912838,-0.038752448,0.0046316185,-0.025082126,0.019467847,0.026315296,-0.05704175,0.013011177,-0.0529634,-0.08855609,0.012876862,0.11433318,0.060839925,-0.0017859951,-0.05151456,0.14610694,0.0043408796,-0.05815591,-0.0073311655,-0.04778349,-0.021632686,-0.0032149157,0.026608681,-0.006334638,0.060523167,-0.10542714,-0.022237234,0.014853548,0.011922172,-0.04712854,-0.101695605,-0.036359716,0.037125815,-0.0036311503,-0.014837671,0.050472967,0.08207647,0.030171072,-0.046832196,-0.012830168,0.038738113,0.021188796,0.020338085,0.017328788,-0.010354477,0.015943907,-0.06586772,-0.040274527,0.010237547,0.015128133,-0.039557893,0.02843829,0.005519179,0.0087567195,-0.04655598,-0.0565516,0.015316536,0.03501173,-5.6544382e-33,0.04583601,-0.050645325,-0.033009395,-0.090668425,-0.01266173,0.047970966,0.11834358,0.0026833275,0.0785604,0.0008205495,0.06542787,-0.022392556,0.024449456,-0.07200175,-0.00021799917,0.04069208,-0.07100745,-0.02120228,0.015765138,-0.022838727,0.02316127,0.07937453,0.09883626,0.0701741,0.05818356,-0.0548362,0.028852401,0.11174706,-0.045020405,0.020049863,-0.0021501842,-0.04336883,-0.08823596,0.03634665,-0.08487469,0.043875962,-0.063980244,-0.023625014,-0.038147066,0.05591286,-0.022799602,0.079332225,0.04803735,0.033704195,-0.007366451,0.07592357,-0.035723723,0.028957086,-0.040274177,-0.098631375,-0.040202696,0.055124804,-0.01122613,0.052569192,0.0326935,0.016417995,0.0028293047,0.04188354,-0.019714048,-0.052210215,-0.03876263,-0.05982266,0.030973895,0.00062419806,0.029673392,0.010880828,-0.05375375,-0.020539718,0.0054266886,0.02000109,0.06340863,-0.04767301,-0.0002445652,0.04317277,-0.0061022798,-0.02315143,-0.07367444,-0.06314667,-0.013062541,-0.10715571,0.0074192723,-0.020778498,0.008262902,-0.054543167,0.039207727,0.0016002064,0.030717086,0.10777012,-0.0067305914,0.05904657,-0.0033805952,-0.0034878645,-0.100644,0.040458035,0.057099722,-4.607624e-08,0.0540861,-0.053427275,0.055107687,-0.031044414,-0.016426269,0.017501019,0.0015751525,0.036568593,0.028183091,-0.080172405,-0.017981382,0.11720671,0.022586688,0.06371062,0.042668726,0.048536096,-0.03774789,0.08100306,-0.028592551,-0.07734823,-0.00867343,-0.03679554,-0.08925783,0.03628541,0.0048849043,-0.011498411,-0.027454581,0.031968717,-0.02131127,-0.0049099484,0.033458415,0.008719839,0.007924225,-0.079990804,-0.02528417,0.018672101,-0.08087222,0.026729861,-0.05479199,0.07553341,0.017291503,-0.10613686,-0.11799875,0.011963134,0.036367834,0.040651694,-0.022038937,0.0006136254,-0.010529582,0.044100255,0.06313891,-0.010734556,-0.006448805,-0.015204542,-0.068316005,-0.06849804,-0.07746918,-0.074552156,0.04442219,-0.0640943,0.059876528,0.056031812,0.1419446,-0.022812974 +2.7.8.44,Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls. This enzyme adds the first glycerol unit to the disaccharide linker of the teichoic acid.,384,0.99999994,-0.01987683,-0.06501307,-0.1087335,-0.0049304953,0.009197717,0.0845543,-0.10323813,0.05247248,0.06765624,-0.06064101,0.08890276,-0.08611882,0.000795682,0.018808244,-0.0530717,-0.06881456,-0.004410666,0.009568494,-0.076355204,-0.06497448,0.004842586,0.054505873,-0.030021999,-0.0024766442,0.014247626,-0.032174792,0.0062124897,-0.012714345,0.031521067,-0.036187608,0.034502834,-0.061285563,0.029785033,-0.07771085,0.0634654,0.07520007,-0.019227628,-0.0037950114,0.09070015,0.03424932,0.017965605,-0.0036469053,-0.0015370065,-0.010591465,0.010151765,0.040840607,0.014058662,0.072421305,-0.028931266,0.0034748288,-0.046856098,0.06839399,-0.07082778,0.027065393,0.04010748,0.09062406,0.035515863,0.04064165,-0.012686171,-0.002921213,-0.018884981,-0.0133572575,0.03429854,-0.022741383,-0.052571822,-0.08727829,0.07006905,0.01255753,-0.005530939,0.017271515,0.0019599323,-0.004609389,0.069990605,0.034615573,-0.0042011878,0.06610807,-0.04118496,-0.011517837,0.020320179,-0.03437088,0.023973648,-0.061087966,-0.049309168,0.055157304,-0.052189417,-0.05456533,-0.0010971777,-0.06695362,0.06232866,0.05491677,0.077306,0.004849566,0.016142609,-0.080189854,-0.04099686,-0.01584192,-0.019436326,-0.05429555,0.034161076,-0.09584911,-0.045761835,0.020294163,-0.0049529546,-0.04829811,-0.076069124,0.017080992,-0.020590562,0.13302155,0.020641837,0.048742827,0.06515099,-0.015772572,0.04442526,-0.0064816475,-0.016987825,0.027437048,0.054156933,-0.11753774,-0.0015203721,-0.021777513,0.036966052,-0.022879288,0.047232997,0.046207257,-0.06735052,0.018170998,0.010776468,1.7231057e-33,0.13194539,0.027795708,-0.06921007,-0.043160506,0.016517056,-0.026725432,-0.11918364,-0.034586467,-0.03597214,-0.0018701816,-0.07120759,-0.056152456,-0.026127852,0.04119176,-0.03249018,0.05122969,-0.029640896,-0.0048562028,0.0040119174,0.011266793,-0.03347423,0.08742038,0.027109925,-0.028461978,0.05039409,0.09195544,-0.0062299618,-0.039358374,-0.0373853,-0.0045819436,0.022370921,-0.022392862,-0.11415987,-0.004931987,0.19002365,0.05659567,-0.073107034,-0.0028548327,0.0076512326,-0.0007124697,0.007815128,0.055724297,0.048670862,-0.05400791,0.07434061,0.043287408,-0.005801037,0.040419303,0.010555657,-0.0016157819,0.07184997,0.01988364,0.09336051,0.039157566,-0.05606933,-0.0105954185,-0.049625386,0.030063942,-0.022266963,0.053440932,-0.033474177,0.05221899,-0.021470916,0.031539656,-0.010529056,-0.013950144,-0.08441632,-0.0053366213,0.047001556,-0.02416949,-0.039887883,-0.055917487,0.096519195,0.034730673,-0.05824612,-0.009148981,-0.059298392,-0.0062012454,0.010075866,-0.07502764,-0.045313217,-0.0026602987,-0.03505476,-0.030319551,-0.037902564,0.022955908,-0.009044833,-0.029321795,-0.05242826,-0.0105957175,0.084508546,-0.038960185,0.022951601,0.10886107,-0.015402457,-4.2323384e-33,0.0836724,-0.086594455,0.10968814,-0.07243781,-0.03667306,0.030874442,-0.05554329,-0.02699166,0.00326929,0.02619197,0.0477734,0.04023592,0.015186898,0.010170965,-0.0053181406,0.029900173,0.055864144,0.07492981,-0.068791345,-0.0965945,0.048512906,-0.05654876,-0.012168493,0.0018979503,0.044393264,0.07360947,-0.010568828,0.010159032,0.036442827,0.030749518,-0.0047236634,0.029031975,-0.08747547,-0.088849224,-0.008966508,0.084745914,-0.03778067,0.017638577,0.06984849,-0.037137892,0.09312104,0.038245108,0.030426541,-0.008203366,0.06139295,0.0713567,-0.019080956,-0.06919008,-0.09956517,-0.025761649,0.018257784,-0.016516177,-0.00045616145,-0.015876213,0.023419607,0.055453643,0.0310397,0.057446636,-0.02607262,-0.06812289,-0.020866295,-0.10284621,0.026351029,-0.006185767,-0.029053643,0.027358113,0.040560216,0.027919557,0.099820234,0.020047314,-0.023430996,0.06758798,0.03676424,0.008247025,-0.010048273,-0.014375388,-0.11664849,-0.09480113,0.0068726507,-0.010845602,-0.027489768,0.021497365,-0.0010839902,-0.05506227,0.07614161,-0.08043771,0.030290768,0.12738873,0.02103003,0.04898535,-0.06452015,-0.018524311,-0.01621099,0.020630147,0.05559959,-3.1950545e-08,0.04797259,-0.06608047,-0.0012956015,-0.060190342,-0.034966286,0.0053230706,-0.0023362509,0.04793603,0.0034219953,-0.008866233,-0.0037149426,0.04356449,-0.041410472,0.008734465,-0.014898715,0.092060074,-0.11007141,-0.102789834,-0.023870919,-0.044538505,-0.051588286,-0.0009112894,-0.08942377,0.09561522,-0.007378161,-0.06990932,-0.06223874,0.01161987,-0.06057105,0.006541057,0.06510521,0.008680037,-0.06004142,-0.0024930527,0.00034180123,0.032769572,-0.026735721,-0.035280947,-0.011705468,0.009918048,-0.006718823,-0.0046096807,-0.09799857,0.051341813,0.07199064,0.039351635,-0.03329678,0.09030737,-0.08992092,0.0115475785,-0.010613677,0.004310056,-0.028220344,-0.0464695,-0.09573464,-0.04941473,-0.016561845,-0.04043123,-0.005757921,0.00660631,-0.020311726,0.05062231,0.102402605,-0.08990221 +3.4.19.15,"The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolysing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. The enzyme contains Zn2+. cf. EC 3.4.19.12, ubiquitinyl hydrolase 1. In peptidase family M67. ",384,0.99999994,-0.06676787,0.0018549901,-0.08029002,0.012992413,0.061220616,0.025974194,-0.028894316,0.014982329,0.007611259,-0.07016421,0.0033648817,-0.03901597,-0.03286591,0.05079101,-0.11244899,0.005784856,-0.03869558,-0.006488612,0.0146601,0.00012765916,0.11831118,0.10348176,-0.055396426,0.041527808,0.07528136,-0.049315255,0.06654189,-0.022561975,0.0550019,-0.095679455,0.04047677,-0.0705621,0.04390467,-0.07345688,0.07303611,0.07027574,0.02280338,-0.1168376,-0.0028694735,-0.046072315,0.084378645,0.05429226,0.004178087,-0.003126962,-0.017425904,0.030431472,-0.0040298793,0.01883357,0.055950537,0.07007799,-0.048706234,-0.079636484,-0.013600626,0.019908551,0.04007147,0.01628404,-0.09336,-0.03891051,0.03775043,-0.030536003,0.011669502,0.07126441,0.029541062,-0.036027778,0.023351861,-0.044132512,0.013569739,-0.06137293,0.028824558,-0.08424855,-0.050983053,-0.02890602,-0.070301056,0.03585611,-0.050613835,0.025378104,-0.053515427,-0.019800344,-0.005557178,-0.03541443,0.008727742,0.00021302499,0.1020404,0.07603434,0.025574334,0.004088412,0.013149315,0.015650827,0.009491389,0.0043888744,0.06959849,-0.021084957,0.033333395,-0.011299521,-0.043691725,0.0106803095,-0.0054281848,0.007688159,-0.041289352,0.038928527,0.04583313,0.03732912,-0.0030349349,-0.115991496,-0.040978815,0.07016352,0.0006727919,0.08392013,0.06434542,0.010901795,-0.030996153,-0.013330554,0.027716247,-0.013333844,0.03861769,0.023880428,0.00071121677,-0.03946379,-0.04024902,-0.016758567,-0.03247859,0.010871188,0.023476781,0.05520303,0.0010356351,0.034503024,-0.17146362,5.5217822e-33,0.09490568,0.020543272,-0.0055418676,0.03168758,-0.06928183,-0.025548007,-0.07093482,0.0042100674,-0.041958,-0.08098245,-0.082988694,-0.014995997,0.021950407,-0.0076664393,0.023807824,-0.01937255,0.0029083048,-0.03089476,0.033427455,0.05324522,-0.07442041,0.02174749,-0.020561296,-0.041794907,0.06619624,0.019005891,-0.019517876,-0.06857233,0.012253131,0.013237394,-0.022831704,-0.07972414,-0.12600483,0.040082417,0.072407015,0.012731522,0.045186475,-0.08307861,-0.058225375,0.0011068251,0.043430187,0.014336795,-0.08915803,-0.009292897,0.087050945,-0.03644202,-0.01458446,0.102693655,-0.02037208,-0.031173468,0.032257624,0.026222382,0.07645841,-0.041107133,-0.10634169,0.06063703,-0.0020443043,0.037537895,0.074664585,0.041899815,0.008908343,0.012922246,-0.023066802,0.06355265,0.01239316,0.027312841,-0.060447387,-0.0005877986,0.016271513,0.063439064,-0.09605192,-0.06252748,0.086680576,0.04851215,-0.037310284,-0.14163871,-0.009943265,0.01973983,0.065902285,0.030932216,-0.044652607,-0.0065510897,-0.021987816,-0.032686207,-0.0065603144,-0.009402009,0.06405866,-0.048765726,-0.0341053,0.05582285,0.010867237,-0.047336955,-0.021874178,0.046733603,-0.015514774,-5.583693e-33,0.08291255,-0.13116288,0.0076089045,-0.014102522,-0.012917864,0.052343443,0.03102028,-0.012150161,0.0044742376,-0.09311755,0.09995063,-0.034304835,0.08715636,-0.085407846,0.05382131,0.023617025,0.010565863,0.067532524,0.057171393,0.00029824092,0.010072826,0.01021514,0.014279576,-0.02483772,-0.005081271,0.016831495,0.007762624,0.09369116,0.06985926,0.018769328,-0.032492187,0.06430159,-0.06704341,-0.09066032,-0.1285771,0.042957917,-0.03814029,-0.010314994,0.02730678,-0.027925264,0.012625911,0.0049354555,-0.055351157,0.04263471,0.058626723,0.08564649,0.010083272,-0.030978005,-0.038029548,-0.05931722,0.08720997,-0.045351468,-0.03445457,0.0893026,-0.021666218,0.019237047,0.035202038,0.08744409,0.027366595,0.014146385,-0.046187334,0.054440368,0.038013767,0.057920426,0.027661482,0.022919893,0.0419347,0.01275728,-0.0023092623,-0.0057465336,0.04411772,-0.049532857,0.10480426,0.07976052,0.024339866,0.051943444,-0.09992984,-0.012353934,-0.00744283,-0.07574486,-0.040741857,0.008156306,-0.014763143,-0.01253942,0.03345324,-0.05819333,0.059628718,0.12647699,0.012740358,0.025826009,-0.040459245,-0.019450871,-0.06897046,0.012818509,0.02713575,-4.4358796e-08,0.058474343,-0.042689417,0.012708301,-0.056300145,-0.018145803,0.049528193,0.0019439486,0.017634068,-0.062361516,-0.05735824,0.023977293,-0.012482392,-0.0040567974,-0.040607907,0.026168713,0.068906724,0.031419568,0.062704846,-0.023242718,0.0067088977,-0.03106829,0.050691392,-0.007895512,0.034875493,-0.03131366,-0.024256233,0.008493928,0.056581162,-0.0049522324,-0.05740748,0.0010116323,0.057968434,-0.011198136,-0.11559933,-0.056427192,0.07066002,-0.0032432147,-0.07029378,0.038827363,0.009875014,-0.028386243,-0.0284244,-0.04074811,-0.041505743,-0.006003356,0.022233749,0.066447645,0.032899205,-0.0328607,0.0083291065,0.024366649,-0.05818131,-0.061288405,-0.10212848,-0.050481115,0.018630508,0.03406808,-0.13387579,0.022942325,-0.1144562,0.013790294,-0.0053637265,0.0920027,-0.044286292 +3.5.1.121,"This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn. Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.",384,0.99999994,-0.07623307,-0.04706851,-0.04484347,0.09304711,0.05504937,0.023915106,-0.029409844,0.0688235,0.03323888,-0.09940835,-0.014081621,0.003923984,-0.054910425,0.0022459612,-0.09223797,0.008665092,-0.07032818,-0.089693375,-0.00010770557,-0.05644612,0.056406774,0.08242076,-0.040863995,-0.03514523,0.058982544,-0.10403739,0.043940403,-0.047444068,0.039996564,-0.13743569,0.07741821,-0.054009255,0.054302093,-0.013477172,0.059638042,0.08572144,0.010375371,-0.08291924,0.0013904846,-0.022453545,0.09582584,-0.018297503,-0.00082453585,0.0027288687,0.06234173,0.019620301,-0.027080176,0.008595104,0.058498643,0.061978016,-0.038480774,-0.0011272047,0.022929054,0.022118421,-0.008292011,0.02626708,-0.11522335,0.003796116,0.0025097886,-0.016953517,-0.0038403799,0.04553364,-0.012655479,-0.032471925,0.023430908,-0.069959216,0.09722049,-0.059206106,0.073854856,0.0829449,-0.025462357,-0.003978441,-0.064806774,0.043016475,-0.024943674,0.023039173,-0.110021256,-0.046158113,0.022385992,-0.042124037,0.06882252,0.016215626,0.08822,-0.007446481,0.0016316555,-0.06285941,-0.04148958,-0.032205705,0.044813495,0.032372985,-0.041096073,-0.031394742,0.05329118,0.04902377,-0.052616294,-0.0009346889,0.10541241,0.084086515,-0.069119,0.04902047,-0.0330734,0.069166854,-0.08706215,-0.058607742,0.014243179,0.0045911935,0.028394055,0.02561042,0.090478666,0.011586733,0.03561645,-0.043274164,0.01775463,-0.032387983,-0.008104523,0.079105236,0.0060653696,-0.0762576,0.021749023,-0.015413503,-0.009550849,-0.0016807321,-0.0034319793,0.07673416,0.011995878,0.049788374,-0.066014014,1.0867983e-33,0.06952155,-0.021743339,0.02241256,0.012628009,-0.04584204,-0.027778136,-0.09521012,-0.04075796,0.014096515,-0.11404577,-0.029678091,-0.084480345,0.030528214,0.06372465,0.014906732,-0.051881816,0.020566704,0.018314488,0.03791799,0.005628633,-0.030012945,-0.060267646,-0.06519283,0.008172838,-0.041078806,-0.01910979,0.027993714,0.07270871,0.015276577,0.008831954,-0.029757917,-0.013233151,-0.10025513,0.06995849,0.00051844283,-0.03528188,-0.04370253,-0.035788488,0.023277229,0.059555914,0.020484503,0.028879797,-0.037686884,-0.05021978,0.05821629,-0.09904248,-0.030116837,0.06834873,-0.020117072,0.025459532,0.016299417,-0.05134844,0.15251768,-0.045468803,-0.059187148,-0.012892383,-0.050207213,-0.030152753,0.020952428,0.035276428,0.025906507,-0.036181074,-0.015596451,0.10386014,-0.048303336,0.037739802,-0.012104671,-0.017818961,0.0020678667,0.028604947,-0.08895774,-0.053202745,0.070953906,0.05079182,-0.009939424,-0.047735654,-0.095381446,0.1130582,0.07138968,0.0020459096,-0.013847954,-0.002307901,-0.03907714,0.015310366,0.02169219,-0.0056083873,0.07402608,-0.06512443,0.019459097,0.015650997,0.033532023,-0.07031114,-0.0735255,0.07773143,0.05113946,-2.1069384e-33,0.060142945,0.015954876,-0.0031485397,-0.010677728,-0.0559678,0.036709018,0.08252826,0.068869784,0.040438358,-0.033888135,0.08748946,0.013138406,0.08640372,-0.035063557,0.057469487,-0.020652393,0.015087978,0.06287939,0.019639535,-0.02699512,0.035781078,-0.030207315,-0.04066935,-0.002907592,-0.010018065,-0.0035011512,-0.06136585,0.027453896,-0.0028096936,0.040915743,-0.035962652,0.01704109,-0.059386797,-0.008234496,-0.055455524,0.03198697,-0.0011832322,0.00082777056,-0.015117601,-0.080587804,0.045286424,0.04494565,0.0054235524,0.08271172,0.07970624,0.084019415,-0.0008390021,-0.0026251257,-0.060287163,-0.10361623,0.030100519,-0.033097636,0.014513833,0.016255416,-0.0936167,0.05125009,0.07455702,0.062183425,0.016186254,0.039204955,-0.011284482,-0.009420569,0.0638273,0.0065087555,0.017641814,-0.005597713,-0.013479245,0.0896176,0.0017219225,-0.038021404,0.039712254,-0.0044482215,0.050270896,0.053974293,0.0082014995,-0.06308793,-0.072274774,0.0025464841,0.021813612,-0.06998291,-0.07854603,-0.07285116,-0.03541927,-0.043159734,-0.013286135,-0.021788258,0.03371447,0.07299017,-0.009585431,0.08752872,-0.0514688,-0.06727182,-0.10259023,0.023724634,0.0065136314,-3.9277758e-08,0.065896586,-0.0027569628,0.0011759311,-0.042470865,0.050017823,0.049196165,-0.029783513,0.060634777,0.022383226,-0.012744824,-0.01641884,-0.0009167421,-0.002233109,-0.026086321,-0.0044960687,0.040638942,0.020368442,0.058415417,-0.02698254,0.043759216,-0.06094671,0.0064301305,-0.027835887,0.026874108,0.041186105,-0.0007632709,0.07567326,0.11785523,0.0053606634,-0.12005649,0.03632077,0.051930096,0.010447763,-0.0024456466,-0.10639299,0.018682068,0.0010009538,-0.07555589,0.058287606,0.06799536,-0.07380415,0.04166053,-0.030428337,-0.009234799,0.0023009935,0.02866751,0.045055453,0.026120842,-0.080600046,-0.014977277,0.024048854,-0.11194496,-0.033560753,-0.11256367,-0.036419597,-0.054021377,-0.056544777,-0.04286197,0.0651953,-0.03957051,0.019464254,-0.0064374576,0.07217951,-0.011197562 +3.5.1.122,"This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln. Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.",384,1.0,-0.05593358,-0.043645922,-0.014943041,0.04624001,0.037050843,0.0049852724,0.017574906,0.050122127,0.021144843,-0.056491744,-0.012896767,-0.012288152,-0.01915451,0.013605519,-0.038478635,0.010328886,-0.090801254,-0.09552678,-0.009592334,-0.07065852,0.058821857,0.12913704,-0.080777116,-0.08109512,0.03271988,-0.042006798,0.06988532,-0.02221997,0.050132528,-0.10963698,0.048000455,-0.04729516,0.044659935,-0.0408686,0.04935782,0.089522235,-0.0395147,-0.059739325,0.03843849,-0.0438304,0.05613231,0.04031167,0.015326659,-0.013429043,0.06277173,0.020718984,-0.001647438,-0.017957326,0.032060485,0.056954015,0.019259043,-0.015774675,0.05967808,0.040555242,0.06529897,0.013368806,-0.12482314,0.0006616941,0.0016206964,0.015133402,-0.018601948,0.04049742,-0.017408915,-0.060865976,0.027408805,-0.07746416,0.14902438,-0.072118446,0.09120057,0.03551487,-0.061298754,-0.00831776,-0.07384418,0.0069872066,-0.04711688,0.01687882,-0.064510055,-0.031177668,0.05128726,-0.029193243,0.07624483,-0.0012212029,0.09916014,-0.0005694983,0.012082192,-0.058956224,-0.049421545,-0.026537543,0.034882955,0.013789895,0.005876882,-0.043746576,0.023274915,0.038376004,-0.068001926,-0.0005731311,0.05005846,0.05949933,-0.08082013,0.053792674,-0.009617102,0.06920587,-0.056640174,-0.048227333,0.01421197,0.0252455,0.06798158,0.06170966,0.030608727,-0.001058727,0.03932615,0.0042856843,0.01563049,-0.011304265,-0.041023165,0.09376338,0.032981858,-0.061993502,-0.00755903,-0.005401839,-0.004804061,0.018577946,0.013092826,0.045625195,-0.033243593,0.028106032,-0.052034214,1.3477358e-33,0.05627168,-0.05565196,-0.0002748862,-0.011234942,-0.007934071,-0.041119494,-0.11993147,-0.024927638,0.05463498,-0.06909337,-0.043170474,-0.05948709,0.02293004,0.064183444,0.017320957,0.008219741,-0.014700197,-0.014055599,0.07540049,-0.0014438878,-0.034881495,-0.06891153,-0.038787052,-0.010958037,-0.04811836,0.04375027,0.053636886,0.05579371,0.014083358,0.007678653,-0.046487395,-0.027955232,-0.084862165,0.07436438,-0.02078084,-0.017229892,-0.034241095,-0.022966927,0.05105877,0.06579716,0.018004933,0.024610074,-0.0525352,-0.031131463,0.08429038,-0.068609655,-0.05245911,0.067823224,-0.049511638,0.061695054,0.03640064,-0.073601745,0.119257785,-0.031592485,-0.09117593,0.008644583,-0.029304815,-0.049445417,0.03942272,0.055675615,-0.00291851,0.010466212,-0.014117807,0.10347574,-0.02858398,0.0401988,-0.032214336,-0.06553098,-0.0056971456,0.046175327,-0.046279434,-0.0716446,0.07336514,0.060672127,-0.03359759,-0.07642925,-0.08543634,0.09778882,0.095361605,0.030499497,-0.0073841945,0.011085027,-0.02551967,0.0058293343,-0.0018439362,-0.03506369,0.049740665,-0.08477013,-0.015547193,0.021247355,0.011213361,-0.009287868,-0.043668017,0.08946903,0.02764001,-2.2881383e-33,0.09176194,0.024324127,-0.015267308,-0.036796365,-0.030334238,0.03434781,0.05950539,0.04303511,0.035362743,-0.024011113,0.0704716,0.0084237065,0.06858894,-0.011921202,0.07472091,-0.050484054,-0.021978911,0.052322168,-0.022995846,-0.028218484,0.058631342,-0.03051463,-0.027304595,-0.017806184,0.01737606,-0.026574409,-0.054978915,0.030827673,-0.0036472294,0.030639581,-0.05550825,-0.0059948135,-0.042169787,-0.005290313,-0.021490673,0.028255366,0.029170964,0.020540366,-0.02997371,-0.0481068,0.056980018,0.09686649,0.005336296,0.06531815,0.06383539,0.115481354,-0.008419885,-0.025608541,-0.07758412,-0.11932871,0.059421133,-0.022436729,-0.002635632,-0.029440429,-0.07298799,0.048787285,0.084023,0.014394952,0.009556563,0.05471611,-0.02843754,-0.033338364,0.026048427,0.024910862,0.034488823,0.012240373,0.053277113,0.092338465,0.0008327777,-0.014079394,0.054916844,-0.03998118,0.058939014,0.041770756,-0.018057419,-0.012944328,-0.08861177,-0.013532778,0.057558153,-0.11902857,-0.0059355986,-0.068344995,-0.026922282,-0.0242117,-0.011684855,-0.08595141,-0.00020486194,0.097145684,0.035950452,0.08323527,-0.06492778,-0.047309175,-0.10318932,0.0054613636,0.00418195,-4.0601144e-08,0.0509426,-0.03952171,-0.03660919,-0.0051863673,0.02984838,0.07363609,-0.036396667,0.064388275,0.047425326,-0.0188552,-0.0006910178,0.03729244,-0.049288597,0.007323369,-0.040916838,0.060872078,0.008766429,0.036409505,-0.027723337,0.02303973,-0.08679014,0.008304637,-0.036272675,0.003265623,0.032524135,-0.029505689,0.058190107,0.1240326,-0.015355181,-0.109967716,0.023526056,0.06809425,-0.036089424,-0.017437562,-0.122205034,-0.012086835,0.023868563,-0.06943005,0.01759139,0.053559065,-0.09218561,0.061824214,-0.053698562,-0.028079739,0.0057722987,-0.011947342,0.021675529,0.020485915,-0.065802954,-0.014009843,0.04004432,-0.11070265,0.011479755,-0.09655082,-0.067724675,-0.05709226,-0.07525751,-0.02922866,0.056154076,-0.07125435,0.03663857,0.011764768,0.057585858,-0.003226372 +3.5.1.123,"The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the opposite reaction from that catalysed by EC 6.3.1.18, gamma-glutamylanilide synthase, which is part of an aniline degradation pathway. Its purpose is likely to maintain a low concentration of N5-phenyl-L-glutamine, which is potentially toxic.",384,1.0,-0.118505925,-0.053426985,-0.071378686,0.019187132,0.021241812,0.041827884,0.0013230939,0.054481763,0.06537508,0.011974638,0.012466395,0.0073277596,0.0005843501,0.007915173,-0.089522794,0.07700487,-0.039367355,-0.049159274,-0.068442926,-0.08778197,-0.031658947,0.06531305,-0.043323,-0.02461707,-0.014061328,0.0025687795,0.0020702002,-0.03511277,-0.014826068,-0.08667196,0.008719792,-0.08277111,0.027631728,0.0037274149,0.06167742,0.067466274,-0.0143977795,-0.10012641,0.09585908,-0.02702946,-0.04722069,0.044047296,-0.05206171,-0.022560148,-0.009389756,-0.014525722,-0.035491545,-0.012045237,0.04597926,-0.03099343,-0.009820568,-0.04775054,-0.04811634,-0.002104279,0.023137834,0.003499129,-0.08965626,-0.11097494,0.006536074,0.0611321,0.017346969,0.026875574,-0.015719611,-0.038645618,0.057458382,-0.12246047,0.09156049,-0.09129602,0.0137042785,0.002278662,-0.061996292,-0.1211241,-0.0053018937,0.03974926,0.010063496,-0.028436918,-0.014975934,0.008808642,0.04592013,-0.006599511,0.03526905,-0.035117045,0.048667893,0.10595252,0.051396944,-0.07073498,-0.0022943686,0.029189542,0.14391781,0.043291133,-0.0028162412,0.03129229,0.071749926,-0.015694434,-0.040585157,0.032414168,-0.014036752,-0.011736407,0.038626928,0.01148022,-0.011809337,0.05726756,-0.008152599,-0.032908823,-0.004232312,-0.025244871,-0.005432751,0.094562165,0.0785286,-0.013705961,-0.020959174,-0.007161826,-0.034109708,-0.0040742205,-0.0591769,0.08348371,0.03648449,0.026162729,-0.08773615,-0.0421059,0.0055325576,0.01338938,-0.028084219,0.07919718,-0.036342114,0.05144619,-0.13137874,-1.7960919e-36,0.06922648,0.013105655,-0.0068524806,-0.0711884,0.0058635613,0.0050611324,-0.09298099,0.05598766,0.03295552,-0.07384441,-0.055826824,-0.06771154,0.016040564,0.023925222,0.011549284,0.014098417,-0.04334178,0.00313531,0.016821727,-0.016209997,-0.0077172313,-0.042802576,0.03739946,0.045785,0.024137676,0.102447465,0.019864997,0.00039408088,0.003464342,-0.004736506,-0.03217328,-0.07068814,-0.07890648,-0.005299316,0.0590419,-0.019033333,-0.088704,0.02843624,0.010616035,0.13579477,-0.014480271,0.035260156,-0.021631217,-0.012999806,0.076503366,0.0013869917,-0.022597186,0.09173927,0.006076974,0.043580495,0.00889633,-0.03535504,0.07060356,-0.020239312,-0.048061606,0.07127111,-0.005083427,-0.008065502,0.048442636,-0.0022510684,0.020435313,0.046547588,-0.029978214,0.0054128454,-0.047390647,0.0461698,-0.018917281,-0.019076962,0.040647373,0.07778879,-0.06304714,0.021208482,0.047647886,0.072956495,0.02835417,-0.11116271,-0.056731522,0.052406978,0.05893815,-0.020207396,-0.019143522,0.02934785,0.039463397,0.012915399,-0.06078301,-0.053714756,-0.025899246,-0.021201247,-0.035864584,0.013418082,0.059608724,-0.04517454,-0.054822426,0.020503473,-0.024769679,-1.1766849e-33,0.08209592,-0.09155618,-0.066180915,-0.039463826,-0.04846951,-0.051684886,0.016557094,0.006892437,0.008095112,0.0209387,0.038966257,0.0458923,0.075240776,-0.0030503396,0.040926516,0.001991236,0.00798719,0.03543994,-0.06891105,-0.06304539,0.028521935,0.013662169,0.02199104,-0.015415419,0.022465669,0.0011536364,-0.021571388,-0.008172985,0.082976826,0.03424024,-0.010002816,0.021396277,0.004623009,-0.10137652,-0.006234175,0.04653493,-0.009092648,-0.005149735,-0.027953148,0.0007821193,0.08783827,0.08676998,0.031684782,0.07785211,-0.0004691877,0.13557571,-0.008447682,0.022804819,-0.040451445,-0.10055086,0.07565629,-0.0042367475,0.004758985,-0.026152909,0.0051659076,0.053114437,0.023808025,-0.04345064,-0.047160696,0.031265058,-0.018901052,-0.05232018,0.07039123,-0.005820796,0.028111842,0.08036102,0.024557058,0.10628701,0.019722816,-0.038893424,0.11656971,-0.036576673,-0.0066437502,-0.0069559654,-0.06823668,-0.051654745,-0.03127756,-0.039195534,0.0203329,-0.033501484,-0.014424693,0.010014263,-0.006501343,-0.016645012,-0.011908542,-0.028043818,0.0031325105,0.14330621,0.012197783,0.07232428,-0.009979893,-0.019019725,-0.0380652,0.08948061,0.043612543,-3.5107693e-08,0.004510495,-0.04544975,0.0112708965,-0.017739624,0.055629496,0.093333215,-0.003930174,0.054496147,0.082910076,-0.051001813,-0.024574528,0.07006296,-0.041632418,0.0319229,-0.08108588,0.053570077,-0.049159214,0.02052881,-0.008194108,0.009731925,-0.08190934,0.0010000506,-0.08142652,0.024869932,0.008919912,-0.07247854,0.020481357,0.040948495,-0.035971876,-0.106726125,-0.04069774,0.09124586,-0.00021325577,-0.03132698,-0.104772456,-0.023459716,0.07235819,-0.07203021,0.006632707,0.028210675,-0.03320295,0.050506186,-0.09079212,0.0058335727,0.016386148,0.029768668,0.011339129,-0.027386138,-0.061990537,0.073517986,0.048712354,-0.039871294,0.019600458,0.0058241314,-0.07496571,-0.04337572,-0.03487573,-0.111708716,0.0021573885,-0.056877762,0.020839833,-0.023422444,0.19520094,0.0066696787 +3.5.1.124,"The enzyme, previously thought to be a glyoxalase, acts on glycated L-arginine, L-lysine, and L-cysteine residues within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. The attack forms hemithioacetal in the case of cysteines and aminocarbinols in the case of arginines and lysines. The enzyme repairs the amino acids, releasing glycolate or lactate (70-80% (S)-lactate and 20-30% (R)-lactate), depending on whether the attacking agent was glyoxal or 2-oxopropanal, respectively [3,4]. ",384,0.99999994,0.020145845,-0.07468607,-0.035792086,0.06967146,0.04907625,0.028894406,-0.035016406,0.06548272,-0.011990053,-0.027157273,-0.022268979,0.060596734,-0.053921077,0.02852857,-0.09763496,0.05125309,-0.026430352,-0.034358047,-0.012548624,0.0020936367,0.0271722,0.023612684,-0.07516326,-0.012391645,0.059457008,-0.031895187,0.0019200362,-0.0019033381,-0.03961635,-0.040320266,-0.057550672,-0.08555656,0.020523453,0.025367016,0.000526911,0.09676183,-0.07393829,-0.04201241,0.06637666,-0.026543368,0.03882026,0.010083833,-0.07442625,-0.00092639826,-0.049962822,-0.011583584,0.05387069,0.0020798922,-0.008943426,0.07093261,-0.026039926,-0.07288418,-0.004501725,0.025208836,-0.017429054,-0.019256629,-0.06947454,0.038496476,0.049022503,0.052698474,-0.052157544,0.030934287,0.011348297,0.041028406,-0.0070256847,-0.056837916,0.06270435,-0.050319117,0.0053222403,-0.02279491,0.035545163,-0.06385558,-0.05848464,-0.07223255,-0.0016098594,0.049993794,-0.0739042,-0.054618504,0.0746549,0.011743579,0.051769156,-0.016714938,0.055636257,0.11568142,0.005494443,-0.00577448,0.017497012,0.0014611119,0.015237072,-0.022286022,0.038874414,0.03466046,-0.029843766,0.019181095,0.03852608,-0.07746932,0.04366978,0.009214282,-0.074244305,-0.012819084,0.003367371,0.02398782,-0.037676428,-0.092901826,-0.03581232,0.03759175,0.034204274,-0.025176559,0.07649723,-0.027663674,-0.0053114835,0.048541714,0.07898623,0.008734076,-0.032047216,0.100464374,0.08489324,-0.017399745,-0.06684368,0.017540388,0.029145403,-0.017097699,0.101530656,-0.05210363,-0.050562676,0.009139938,-0.04514742,1.6196093e-33,0.04698936,0.016174689,0.00970736,0.01574558,0.058609586,-0.017091054,-0.068667814,0.015120035,0.061504852,0.041381318,-0.027680267,-0.013030675,0.018189218,0.03739074,-0.03245266,0.07727383,-0.04164658,-0.0061886865,0.029863594,0.015326476,-0.045336414,-0.0130106965,-0.026081767,0.034114566,-0.020147495,0.053981252,0.03267364,0.041515913,-0.024497887,0.027733801,-0.013749515,-0.11027822,-0.11388876,-0.003619005,-0.031063424,-0.018150529,0.0011816494,-0.013043374,0.0011647472,0.03150481,-0.066657715,0.02488608,-0.025741417,-0.058908436,0.03595113,-0.03726213,-0.10922084,0.09443674,-0.0049968106,0.08344974,0.058674183,-0.12163925,0.06031317,0.011357352,-0.057641633,0.02292986,-0.059561174,0.028403975,0.076331034,0.114915535,0.12547958,0.07365271,0.048760332,0.015309155,-0.0074332124,0.035985813,-0.06224557,-0.061453257,-0.05058273,0.06303899,-0.062972136,-0.033525124,0.07584256,0.03410552,-0.02223153,-0.09071936,-0.023015633,0.060056843,0.05111168,-0.009071481,0.037813175,-0.06773647,0.063996956,-0.025077088,-0.054700334,-0.04166097,-0.03909018,-0.037165876,-0.039348356,0.059344247,0.030358804,-0.05146769,-0.043234494,-0.030547451,-0.029213265,-3.285964e-33,0.069803596,-0.13545081,0.007256064,-0.080695234,-0.02355762,0.025711086,0.024657806,0.05875044,0.09304268,-0.014867413,0.046664532,0.023812013,0.01513514,0.014784695,0.032575525,-0.009464456,-0.027779495,0.0022540966,-0.012625481,-0.017033422,0.013910589,0.010626663,0.017751856,-0.010644501,0.09210126,0.041989323,-0.0679177,0.021541765,0.052609548,0.059790093,-0.00773548,0.036919758,-0.03865038,-0.027050007,-0.032907862,0.0988997,0.026292486,-0.036799338,-0.0067694467,-0.05700485,-0.0034695736,0.022820441,0.05189274,0.12052888,0.06802324,0.058653083,-0.07893386,-0.06236829,-0.014851442,-0.095290974,0.027134905,0.039681286,0.00439041,0.06253119,-0.0021217132,0.051582515,-0.0049021393,-0.031295195,-0.040459186,0.04646485,-0.047431536,-0.026540454,-0.043966793,-0.020594819,-0.0077306344,0.049544584,-0.031890433,0.0014073446,0.068883665,-0.019212576,0.09380595,-0.011159668,0.01132443,0.08102929,-0.022277761,0.06268055,-0.037760418,-0.013585192,0.0071780332,-0.049152844,-0.008966465,0.04048629,-0.0077910544,0.0027780696,0.013433655,-0.10141391,-0.008988715,0.18070702,0.03536995,-0.05416108,-0.035634134,-0.043242943,-0.07652071,0.023561684,0.06868273,-4.6537014e-08,-0.017799743,-0.08562442,0.08041217,-0.05129074,-0.06198733,0.027563222,-0.00980072,0.026706917,-0.0036440522,-0.100615025,0.0011655625,0.14983433,-0.012959497,-0.038007233,-0.03773514,0.0024234103,-0.061937507,0.058687586,-0.027391732,0.042567946,-0.09226353,-0.01523205,-0.061443955,0.037740175,0.013813789,-0.08941688,-0.004628261,0.048293076,-0.112594895,0.0033168667,0.045479883,0.04487029,0.00050576555,-0.0070342566,-0.09511212,0.01264556,-0.04586362,-0.008461593,-0.00234756,-0.08486394,-0.105441555,-0.039521143,-0.04353535,-0.022517897,-0.0020288762,-0.027872996,0.008524885,-0.026168784,0.030346725,-0.030366968,0.038492292,-0.02743128,-0.017415727,-0.0069152806,-0.040119234,-0.03361953,0.019453872,-0.06983079,0.02454349,-0.12078487,-0.028030127,0.033956263,0.17575462,-0.016657308 +3.6.1.68,"The enzyme, characterized from roses, is involved in a cytosolic pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance. In vitro the enzyme also acts on (2E,6E)-farnesyl diphosphate.",384,0.99999994,-0.04800661,-0.050658695,0.024930516,0.050616883,0.059194993,0.07562396,-0.03935582,-0.0034486363,0.10828825,-0.030792855,0.02800578,-0.009338908,-0.11514813,0.0019181649,0.04620853,0.08051453,-0.06288857,0.014616237,-0.0077272663,-0.0031416337,0.09552715,0.0155387595,0.016928896,-0.042177252,-0.021511847,0.007589008,0.044783164,-0.003704656,-0.0074478504,-0.092251405,0.08272921,0.07345747,-0.004384404,-0.035946812,-0.056356873,0.04486083,0.027796336,-0.08258925,0.062243972,-0.0013300412,0.06407503,-0.028199112,0.01674878,0.03435084,0.013581104,-0.0117400065,0.052878793,0.028649107,0.010244604,0.008911835,4.4554647e-05,-0.06692325,-0.04309633,-0.03911288,0.026343683,-0.02565913,0.03887359,-0.028503234,-0.03304483,0.035163097,0.04459197,0.0075193536,-0.04330299,0.03057878,-0.057422567,-0.09153686,0.0031073324,0.025665458,0.022916263,-0.1033748,-0.04983862,-0.051417705,-0.029889164,-0.016540017,-0.020800315,-0.018267222,-0.01189294,0.034505498,-0.016055986,-0.061309747,0.078090206,0.018867178,-0.015698284,0.17482397,0.041217364,0.0048143305,-0.021558769,-0.06113199,-0.02877597,0.018238232,-0.015406275,-0.08474099,-0.111135654,-0.033886172,-0.092201784,0.0028670356,0.0693253,-0.011192807,-0.024991056,0.012741189,0.030462677,0.070710875,-0.076569505,-0.030982563,-0.08176792,-0.015561018,-0.07022277,-0.015735805,0.0064778877,-0.013493832,0.002260259,-0.02103806,0.041110106,-0.0025068156,-0.048284806,-0.010829851,-0.0089795515,-0.07593845,0.011847278,0.023638833,-0.049293336,0.002578125,0.09109849,0.07855627,-0.047207735,-0.052117314,-0.04066833,7.340876e-34,-0.043650854,0.0754967,-0.02303284,0.013324801,0.016692009,-0.076740324,0.03388347,0.0451702,-0.07490898,-0.0068680183,-0.09169834,-0.013723312,-0.014175659,0.033687636,-0.0023869534,-0.0004441737,0.02579967,0.009845313,0.03614042,-0.07755885,-0.01516896,0.0124117825,-0.078638695,0.018652951,-0.05072297,0.009973212,-0.04433569,0.03693485,0.035261646,-0.01564175,0.025526935,0.00043617774,0.058550514,0.03196131,0.03257463,-0.0062044095,-0.04395547,-0.031782594,-0.0010219034,0.0134016555,-0.025657162,0.03365878,0.0089946585,0.00484502,0.0035016434,0.03530372,-0.11107442,0.030304985,0.0992072,-0.005730419,0.02855574,-0.042395476,0.13470103,0.112476155,-0.090680175,0.05418496,-0.09889213,-0.0032208306,0.00040316678,-0.032998957,-0.026704187,0.041028272,-0.056255475,0.018747374,-0.030822342,0.027501933,-0.0152515685,-0.052696038,0.004466286,0.16491687,0.014487778,0.07025245,-0.023680529,-0.02363651,0.024960328,-0.0043987124,0.016947307,0.08942639,0.12778239,0.022941414,-0.00023807463,-0.084975384,0.0075608287,-0.023865087,-0.02311926,-0.036711477,-0.007428615,0.04652593,-0.03181248,0.047095478,0.10269842,-0.06663088,0.032821383,-0.04833524,0.018667383,-2.2500964e-33,0.06682003,-0.042171292,0.039630666,-0.09358986,-0.0023889535,0.0845652,-0.0133146085,-0.0067309723,-0.011542216,0.037289426,0.002312734,0.016873062,0.06946767,-0.021667492,-0.042998996,-0.01012549,0.02517377,0.115531854,-0.013397436,0.029857028,-0.06777654,0.05307878,0.041819334,-0.014318824,-0.030675754,-0.033619776,0.023099989,0.010937404,-0.034725603,0.029470617,0.0457661,-0.04659817,-0.060496986,-0.014102703,-0.006776579,0.038913082,-0.051321086,0.034990832,-0.041647214,0.059317075,-0.0077271033,-0.004864313,-0.029633215,0.07460905,0.10713117,-0.0030705812,-0.18468302,0.03281111,0.029581474,-0.04848399,0.04028591,0.034528237,0.008962325,0.017664138,-0.02230302,-0.019798053,0.004719087,-0.07164867,0.025517767,-0.001831844,-0.09622066,-0.077646196,-0.06397657,0.003995033,0.02840181,-0.007243187,-0.04267277,0.08578779,0.003091045,0.016506195,0.06724039,0.056944385,0.0022952356,0.026941907,-0.04670004,-0.047722936,-0.08834661,-0.065976426,-0.0099031795,-0.005532044,-0.042640176,0.030382019,-0.026354313,-0.051841177,-0.06233513,-0.13452275,0.039929878,0.08317219,0.016868087,0.005869043,-0.012918218,0.043380793,-0.02389762,-0.008413288,0.048944656,-3.4664154e-08,-0.032662917,-0.11049712,0.044601917,0.00887095,-0.013762747,0.051632106,0.038599823,0.035035234,-0.0072941696,0.005081021,-0.05193007,0.14092012,0.026702695,0.008844033,0.07754606,0.008002042,0.05090835,0.021048144,-0.039784033,-0.050359793,0.038054746,0.06234038,-0.016822897,0.036527175,0.024537133,-0.05698696,0.03126632,0.021418547,-0.04148813,-0.03685983,0.050577573,0.0210774,-0.015448994,0.028897807,-0.103068404,0.05734226,0.062898554,-0.042160675,-0.060265306,-0.016560633,-0.0090583395,-0.04292536,-0.095922984,-0.0227356,-0.025254458,-0.008897002,0.054309167,-0.02484826,0.028645137,0.03299254,-0.015865223,0.052890196,-0.026293874,-0.024959883,-0.091097675,-0.054578625,-0.030919287,0.0084315,0.026891612,-0.045069594,0.071179874,0.04298347,0.21069665,-0.017288228 +4.2.1.169,"This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green flimentous bacteria (Chloroflexaceae), is involved in the biosynthesis of bacteriochlorophylls c, d and e. It acts in the direction of hydration, and the hydroxyl group that is formed is essential for the ability of the resulting bacteriochlorophylls to self-aggregate in the chlorosomes, unique light-harvesting antenna structures found in these organisms. The product is formed preferentially in the (R)-configuration.",384,1.0,-0.11197236,-0.014626477,-0.12510629,-0.041349493,0.06721981,0.04237912,-0.025997594,0.036172453,0.06757505,-0.004104985,0.025644401,-0.063065805,-0.025914738,0.067828625,0.009055559,0.08944208,-0.111795604,0.012407448,-0.02996136,-0.056077335,0.036125313,0.033813488,-0.03270644,-0.031830788,-0.026805175,0.055313688,0.02089105,-0.038271364,-0.0053300075,-0.08354159,0.003513857,0.0522131,0.044717733,-0.06832706,0.04508945,0.08454688,-0.007998901,-0.12356311,0.046114516,0.021242402,-0.020144774,0.041670375,-0.031159794,0.01824864,-0.11036287,0.01956505,0.059570152,0.08850495,0.04673775,-0.11706194,0.0013212512,-0.0011705982,-0.0992785,0.065526195,-0.010690628,0.044573303,-0.041141275,-0.042749815,0.0199991,-0.067011766,0.082594156,0.029548613,0.052500837,0.030932156,-0.019386038,-0.033063937,-0.03366648,-0.029858077,0.070965245,-0.100833975,-0.096519865,-0.054774333,0.016330719,0.088501774,-0.019138789,0.03526731,0.081924014,0.0019013482,-0.00076370547,0.014757496,-0.02713782,0.0068386374,-0.039437827,0.13460675,0.052171674,-0.002948502,-0.006857169,0.0119734965,0.051858544,-0.00944975,0.018601224,-0.0006805175,-0.06894031,-0.06971738,-0.14761493,0.05670652,-0.002767527,-0.017711738,-0.013985888,-0.06258824,0.00866176,0.00013094858,-0.00035175783,-0.04758589,-0.05939054,-0.09327884,-0.040214248,0.15631889,0.029211016,-0.03630004,-0.01122188,-0.0003995109,-0.022145087,-0.007913889,-0.03780681,0.061934344,0.024835916,-0.042712897,-0.07699084,0.028381212,-0.007850036,-0.01672812,0.028822029,0.026912834,-0.039633576,0.051931728,-0.16068251,1.9047093e-33,0.085904345,0.0064212047,0.03668007,-0.056093488,0.0058659636,-0.06616721,-0.05367288,0.037983976,-0.065375626,-0.07104379,-0.058745038,-0.017545894,0.026499398,-0.01271309,0.00077244,-0.011937161,-0.06878126,0.015113114,0.0039485674,0.009762548,-0.026539415,0.051192015,-0.02502148,0.030156842,0.07024128,0.074997954,0.0075637437,0.015391721,0.06256507,-0.0040770406,0.053319998,-0.050282072,-0.03786896,0.039688352,0.111551814,0.010602547,-0.04154979,-0.011302138,-0.0027241732,0.06717349,-0.015486608,0.016578618,0.047726452,0.02469485,0.05395276,-0.027466591,-0.074866116,0.07414226,0.07003333,0.045234956,-0.0062597715,-0.010242616,0.10203219,0.00015702684,-0.0099702515,0.04977646,-0.0067173447,-0.002943534,-0.030150559,-0.012272207,-0.014003615,0.07336655,-0.050212346,0.048320975,0.04202848,-0.017925361,-0.021068346,-0.018881286,-0.008582278,0.069872186,-0.069877125,-0.014399519,0.02037254,0.03725779,0.09721201,-0.022071598,0.018524393,-0.06725386,0.031675156,0.024051744,0.009828403,-0.04806494,0.044989333,-0.095173925,-0.07804068,-0.04626307,-0.007983036,-0.06076239,-0.012903357,0.032694384,0.010889032,-0.028362688,0.0063854572,-0.00996684,-0.076459475,-3.8801114e-33,0.054933973,-0.105416596,0.043877725,-0.08928057,0.022657668,0.037538696,-0.03781531,-0.050283335,-0.023616694,0.06731524,0.05654191,0.06752759,-0.0642191,0.05180096,0.006917082,0.020031923,0.091578476,0.008314893,-0.035176095,0.0066765784,-0.01686997,0.053927995,0.09003083,-0.01863232,-0.01685954,-0.011903045,0.057028484,0.02414107,0.0139218895,0.026518168,-0.03868011,0.009666899,-0.023598319,-0.010606511,0.0034021852,0.024030894,-0.00092683936,-0.0025232092,0.04028984,0.042343266,-0.0011659309,-0.017581837,-0.003197258,0.0065072807,-0.030847786,0.009358315,-0.05898374,0.038418308,-0.053859767,-0.026507257,-0.0069616106,0.025781754,0.010105154,0.027769918,-0.021783821,0.016478462,0.021387184,0.053178802,-0.0034044406,-0.022633288,0.0029970142,-0.14249222,0.003918049,-0.00863931,0.049649622,0.042694353,-0.016725311,0.07648598,-0.0006235829,-0.0012609854,0.04344509,-0.037884314,0.005534446,0.032974638,-0.075851195,-0.0065101413,-0.017302329,-0.03689892,-0.041106056,0.024689984,-0.011961678,0.04051358,0.014559674,-0.08709453,0.031426802,-0.11103064,0.0010077002,0.07602516,-0.026320662,0.039094344,-0.0007894632,0.032060344,0.02014936,0.08762884,0.10205774,-4.3398952e-08,-0.06700367,-0.088865206,0.030534355,-0.0042874767,0.029986462,0.052845396,-0.024201408,-0.04254724,0.08573464,-0.023761481,-0.048060566,0.06382814,0.012352141,-0.001619824,0.055777743,0.04181502,-0.078494325,-0.0523146,0.009572847,-0.0056729345,-0.06446649,-0.04035427,-0.10342104,0.0393344,0.002347812,0.00076167256,0.057917878,-0.016426265,-0.02126113,0.028572923,0.021773655,0.052088663,-0.009295019,-0.0052000633,-0.08492956,-0.023117926,-0.055931605,-0.034194883,-0.09757998,0.066106,0.0479841,0.07361825,-0.081257716,0.04749861,0.026931183,0.013325866,0.011752802,0.08746205,-0.030525943,0.001982741,0.040358946,-0.020097014,-0.026568979,-0.10782939,-0.124847926,0.010393597,0.021545682,-0.07128972,-0.06150823,0.007724272,-0.029096998,0.028479856,0.15051585,0.023974586 +4.2.1.170,"The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. By catalysing a dehydration of a 2-[(omega-methylsulfanyl)alkyl]maleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates. The enzyme is a heterodimer comprising a large and a small subunits. The large subunit can also bind to an alternative small subunit, forming EC 4.2.1.33, 3-isopropylmalate dehydratase, which participates in L-leucine biosynthesis.",384,1.0,-0.068234734,-0.03546804,-0.067571245,-0.016795339,0.07713174,0.01772008,-0.095519654,0.037648838,0.056247827,-0.06098106,0.0977208,-0.07019055,-0.06582793,-0.056419346,-0.017181592,0.0067187436,-0.10656611,0.017636329,-0.07173669,-0.09085866,0.11453633,0.02619018,-0.09298588,-0.008094233,0.081752405,-0.059136406,0.029465646,-0.009342973,-0.02469437,-0.091680616,-0.0052191694,-0.06197921,0.088680394,-0.04396145,0.03579132,0.10115945,-0.030994983,-0.083540976,0.07928438,0.0090223495,0.093707696,-0.031780027,-0.039616533,-0.064145625,-0.077809006,-0.033424612,-0.019801779,0.051953886,-0.05269165,-0.02145221,-0.0052087046,-0.06653534,-0.03355332,0.017004857,-0.0030890796,-0.041089576,-0.007959522,0.043406952,0.000439287,0.043598663,0.073701926,0.0203552,-0.0045780307,-0.019496886,-0.015385876,-0.09660436,0.025512397,-0.035976227,0.101119265,0.007940508,-0.03735767,-0.05344086,-0.028959641,0.05196043,-0.0035674353,0.00185074,-0.0788073,0.0068252767,0.026041178,-0.018966766,0.049457498,0.015912937,0.023181403,0.040228732,0.019090544,-0.060571138,-0.038797792,-0.005781979,0.061652396,-0.019753162,0.019558992,-0.026124373,-0.048281148,-0.00012536907,-0.01997782,0.07972805,0.0419387,0.006938913,-0.05372559,-0.013124513,0.053694665,0.058417577,-0.032760486,-0.066187285,-0.0071607605,0.008595263,0.021388598,0.08665912,-0.011184427,-0.035340242,0.025577879,-0.041445922,0.028245479,0.04541562,-0.031673487,0.04844926,0.03760989,-0.037060164,-0.052984383,-0.018558694,0.0060289153,-0.0029907776,0.05919756,0.014303455,-0.016932355,0.026430061,-0.16128558,2.3177222e-33,0.088106625,0.00837861,-0.049005147,0.014086511,0.009416715,-0.040846,-0.07507765,0.05477996,-0.068478666,-0.022296574,-0.05018467,-0.06598145,0.029429972,0.031234555,-0.06213776,-0.06480555,-0.03279879,0.0048490004,0.034501612,0.025236463,0.027595144,-0.019201081,-0.08595819,0.0044713966,-0.011061384,-0.0072086733,0.0071117035,-0.031197857,0.034510776,0.0051155454,-0.05199767,-0.06460342,-0.04212066,0.046316497,0.07027508,-0.026559563,-0.04752514,-0.044479184,0.009354171,0.041781094,-0.003055228,0.03972959,0.01954141,-0.06925155,0.07059263,0.081256144,-0.0046717674,0.10929315,0.033902187,0.03373512,0.045377377,-0.0015983162,0.14797592,-0.02815205,-0.0745729,0.025806537,-0.036163278,-0.024762461,2.6733998e-05,0.06896955,-0.015122335,0.07192073,-0.015593255,0.06426976,-0.012255399,0.028303497,-0.12900725,-0.059183676,0.011171027,0.075734265,-0.039421666,-0.089531034,0.07996612,0.04797545,0.019120906,-0.032690417,-0.069113135,0.044104815,-0.02180511,0.042008083,0.019830868,0.029930549,-0.024729826,-0.03697193,-0.092594914,-0.054502033,-0.018102072,-0.037198402,0.053713582,0.048272908,-0.013516959,-0.02081288,-0.019255245,0.051199168,0.03786787,-2.9253595e-33,0.09808789,-0.07273742,0.08046458,-0.05593348,-0.015326175,0.04192934,0.039385304,-0.01373383,0.055236366,0.00055948284,0.065577835,0.026622076,-0.011452934,-0.049149748,0.0575736,0.039643507,0.02405033,0.04274226,0.017826028,0.02232618,0.034364685,0.06300531,-0.0021040826,0.0011285162,0.10058625,-0.03887605,0.08234735,0.069426924,0.044626847,0.032109696,-0.037160005,-0.017209966,-0.01682755,-0.036805924,-0.084511735,0.046607397,-0.07860935,0.023787435,0.033110376,0.0186273,0.013378699,0.0005434141,-0.0021535875,0.068061315,0.09624275,0.018269049,-0.030566094,0.0013417535,-0.052925706,-0.07758202,-0.0048003565,-0.019873792,-0.033185873,0.08199726,0.019321457,0.057111766,0.031624872,0.052812047,-0.013526553,0.0044040224,-0.03518288,-0.07949258,0.0113365175,-0.001563683,-0.012006596,0.0058509503,0.023837576,0.03388459,-0.016402092,0.046146054,0.11733415,-0.037948538,0.024834337,0.04091444,-0.015409127,-0.050583795,-0.0856035,-0.044891007,-0.11239592,-0.07515497,-0.019748237,-0.027014585,-0.0050912467,-0.08770617,-0.0045924243,-0.06973718,0.044431493,0.14875823,-0.020283723,0.11482507,-0.035580598,-0.06290784,-0.025890188,0.094266735,0.07835319,-4.3173493e-08,-0.014284398,-0.025943276,0.04155247,-0.022686949,-0.031402726,0.033147857,0.018062146,0.014232294,0.047420282,0.012288376,-0.025049493,0.047597315,0.01851556,0.018822012,0.019632014,0.022850316,0.028840596,0.080099136,-0.007316841,0.03986083,-0.0505416,-0.020400679,-0.13036124,6.167522e-05,0.00020954438,-0.04525801,0.029178837,0.086806685,0.021286994,-0.081540674,0.03996074,0.09926626,0.04404305,-0.049889136,-0.054934457,-0.012960391,-0.09690197,-0.025146918,-0.0053821946,0.0076585724,0.012536174,0.0067217457,-0.029021075,0.028212322,0.04032679,0.002011511,0.008475423,0.028041039,0.0011522622,0.08390493,0.063749306,-0.035426237,0.032268927,-0.05689289,-0.01968038,-0.025530435,-0.01686573,-0.018088605,-0.022973076,-0.00074158004,0.019061763,0.032960348,0.15310885,-0.08369576 +1.1.99.42,"The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6). It is membrane bound and contains FAD. The enzyme has been assayed in vitro in the presence of the artificial electron acceptor dichloroindophenol (DCPIP).",384,1.0,-0.0663037,-0.015648043,-0.067772835,-0.05954543,0.08380821,0.038079675,-0.0382346,0.098210834,-0.0049607763,-0.0021210955,0.004758324,-0.0039153923,-0.04388252,0.08233979,-0.09514316,0.07600048,-0.06052904,0.009009412,-0.046330508,0.04562115,0.021215547,0.06829149,-0.041397978,0.0042194733,0.024356626,0.033989955,0.09167878,-0.008464935,-0.013262977,0.017879413,-0.04722163,0.027693514,0.03947636,-0.033213444,0.07394323,0.08944533,-0.028050102,0.008120185,0.035920743,-0.032868017,0.052135598,0.0105680395,0.032330424,-0.057772115,0.05846713,0.023916217,-0.00729118,0.060834344,0.052069325,-0.014178213,-0.063970715,0.0044277865,0.020600278,0.06995664,-0.034983963,0.025503732,0.02987644,-0.04902112,-0.021683684,0.03180644,-0.018610392,-0.055679653,0.053308405,-0.0035543963,0.0526271,-0.027168479,0.022578787,-0.050250676,0.0406991,-0.081879996,-0.038404103,-0.065665975,0.03683876,-0.05333208,0.022592733,0.053454358,-0.077409044,-0.09089261,0.0153105585,-0.020872544,0.0476637,-0.05465587,0.052575856,0.14375219,0.06593833,-0.004598415,0.033834603,-0.02951968,0.016228639,0.026337538,0.0004731639,0.031108616,-0.05362633,-0.011059954,-0.12370121,0.040477995,0.004860906,0.03271443,-0.019920489,-0.013118749,-0.054496884,0.013827075,-0.08415464,-0.05363525,-0.06138668,-0.060947545,0.0041991905,0.08589804,0.033913285,-0.0012355264,0.013883693,0.055640075,-0.028587395,-0.014874937,0.06705421,0.0059203287,0.112702444,0.005876818,-0.057001445,0.010193407,-0.022338262,-0.028149711,0.03848138,0.01521064,0.0038280447,-0.025548143,-0.026594324,3.1029943e-33,0.0020239612,0.0054563014,-0.055141825,-0.013401337,0.00934104,-0.019305067,-0.100598514,-0.03748186,-0.024205392,-0.13272968,-0.01388867,-0.018040627,-0.045266807,-0.011805954,0.007743707,-0.012123875,-0.02031926,-0.06643744,0.09962533,-0.03887322,0.09360497,0.035487816,-0.000114835835,0.020081542,0.027890265,0.03994398,0.050039217,0.09065434,-0.022455037,-0.017119514,0.0557138,-0.04014939,-0.1524245,-0.045918267,0.006077008,0.00044839867,-0.083050214,-0.008536126,-0.06827118,0.017462602,-0.03529869,0.004548597,-0.031568594,0.008499831,0.051480755,-0.08681369,-0.083290465,0.12911579,0.035713974,0.02431226,0.016403554,-0.054614674,0.04587372,-0.026061868,-0.09253097,-0.08027402,-0.015635328,-0.060450274,0.020450093,0.052783925,0.089157574,0.023553826,-0.048146613,0.122060254,-0.019189648,-0.025596887,0.0018363941,-0.04216598,0.030704902,0.0229909,-0.027457437,-0.021003872,0.04494951,0.016986918,-0.0025301266,-0.0786102,-0.02416574,0.03124,-0.0014512778,-0.026287423,0.021900775,-0.0819813,0.047679722,0.0024279936,-0.08627712,0.036966294,-0.019668307,-0.07244893,0.03679236,-0.07531918,0.08303457,-0.10445185,-0.04953579,0.06847724,-0.03599026,-2.7647306e-33,0.012255545,-0.06255713,0.12025616,0.02126572,-0.027448807,0.025541883,0.023812756,0.0674595,0.060527876,-0.06144776,0.022361293,0.0012001105,-0.012427052,0.031534556,0.04746892,0.05384989,0.0045560426,-0.004450739,0.04076541,-0.016131662,-0.015224753,0.033766188,-0.026192928,0.011435097,0.01796997,0.07160439,-0.00866025,0.019471433,0.05486869,0.024338795,0.015729154,0.115017444,-0.079865396,-0.002469316,-0.06229634,0.03295383,-0.045531392,-0.00083316915,0.00088631705,0.048253972,0.037231725,9.892934e-05,-0.04947069,0.010819957,-0.019162424,0.06372936,-0.0401414,0.04634092,0.061016582,-0.07412147,0.041151755,0.02435717,0.020377534,0.0047517885,0.029127294,0.03245247,0.016579682,-0.015449331,-0.037228644,-0.0050031114,0.01728033,-0.08991112,0.014738568,0.05484541,0.017739099,0.10224712,0.070360705,0.06361096,-0.003037802,0.037950825,0.14508078,0.064983934,0.030293517,0.04347184,-0.09339263,-0.0068933945,-0.0400374,0.038079377,0.039793555,0.019694885,0.053394035,0.009193857,-0.048916228,-0.036927488,-0.028061986,-0.100870244,0.039384004,0.06277944,-0.044189986,0.017225418,-0.0070105447,0.024554959,-0.056623925,-0.034381635,0.04833316,-3.894373e-08,0.116295405,-0.10109996,0.024356734,-0.06963426,0.029665006,-0.026072854,0.003883685,0.060893856,0.11506863,0.0065358905,-0.07810903,0.0792808,-0.03192353,-0.03673171,-0.012773136,0.04367785,-0.03950015,-0.0030411936,-0.029752376,-0.020705368,-0.06438774,-0.020907708,-0.084922515,-0.014504469,-0.006411513,-0.031199059,-0.009254239,0.019412145,0.0036409872,0.00037042095,0.0010536597,0.01166033,0.07169921,-0.04949595,-0.056125637,0.07842061,-0.020503161,-0.08163172,-0.059617553,0.053512864,-0.013314835,-0.051352534,-0.05863467,-0.015496819,0.02380104,-0.0107980715,-0.029749546,-0.03595772,-0.056244254,0.008608105,0.083174236,-0.0013086031,0.02255719,-0.041915826,-0.1778098,0.039570246,0.012876591,-0.06685026,-0.024938164,-0.06948649,-0.0025403926,-0.008300612,0.12757766,-0.022395758 +1.1.1.404,"Contains FMN. The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, participates in the degradation of pentachlorophenol. ",384,1.0,-0.025665546,-0.004316458,-0.09548681,0.00899879,0.07919338,-0.008457808,0.05208395,0.051389776,0.012935255,-0.061864465,0.015644975,-0.07218709,-0.05446035,0.09273732,-0.109850846,0.04163896,-0.079809316,-0.036462426,-0.039869957,0.019004025,0.008954622,0.030617997,-0.03709362,-0.032366257,-0.08218112,-0.0010341927,0.012702335,-0.041765656,-0.009155682,-0.036783427,0.045191158,0.07907763,0.069107406,-0.057644367,0.119066656,0.061150033,0.008260743,-0.05727137,0.06555767,0.01167455,-0.032384485,0.03190949,0.008185407,-0.068588674,0.0022833333,0.037900116,0.01704074,0.03933088,-0.0029885725,0.02806362,-0.0030028217,-0.013373284,-0.044050306,0.09366018,0.07444658,0.018781677,-0.02416944,-0.04421001,-0.1290867,0.0629436,-0.002881165,0.09413353,-0.03507679,0.0015717775,0.05190086,0.005697567,0.0012660635,-0.12104734,0.0024378279,0.020692686,-0.0023303644,-0.047663882,-0.006284382,-0.019626422,0.010292462,0.06924715,0.056250244,0.007135049,0.023284517,-0.09629354,0.044006288,0.038091604,0.039171774,0.09300045,0.041715387,-0.041285396,0.0012124442,-0.081878275,0.03694603,0.08768227,0.022533495,0.048909917,-0.021696994,-0.10933137,-0.08919441,0.07467866,-0.049541645,0.022755062,-0.0076283757,0.043338027,-0.046290576,0.0047199912,-0.0047261203,-0.11598282,-0.10866118,0.016434938,0.0032540509,0.07774442,0.08809741,0.0051294267,-0.019003982,0.09408229,0.038470272,-0.053614803,0.0035506263,-0.016572656,0.009480517,-0.06440092,-0.005078398,0.09254595,-0.026953565,-0.010429608,-0.032662548,0.123360135,-0.01308128,0.07314895,-0.10349412,2.3317587e-33,0.002235431,-0.018932221,0.07753227,-0.061989296,-0.05843376,-0.03252959,0.039659034,-0.035975873,-0.018626766,-0.09989687,-0.0774638,-0.06449082,-0.020444958,-0.03290273,-0.009230894,0.0068472424,-0.05784502,0.030764392,0.026902264,0.04681162,0.0754145,0.01950845,-0.055094402,-0.049073294,0.06850577,0.05588072,-0.053118225,0.0056023747,0.008273577,-0.0031537183,0.032996133,-0.015548419,-0.09670065,0.002006255,0.041071765,0.009810316,-0.011008678,-0.016862309,-0.06457601,0.079781994,0.027878616,-0.006030956,-0.05200707,0.022184331,0.0819541,-0.023655064,-0.09004635,0.09419373,0.028653884,0.035990737,0.012937222,-0.04698003,0.0104844915,0.016009873,0.0036164606,0.024560986,0.03573177,-0.03564397,0.028896675,0.028444335,-0.010895797,0.10596784,-0.09080875,0.037111677,0.08304214,-0.026133545,-0.020981308,-0.05876046,0.007439588,-0.031429958,-0.0641297,-0.0068909107,0.033570338,0.02543091,-0.011431712,-0.06603031,-0.020882506,-0.0311835,0.018831959,0.024056327,0.022529578,-0.12608993,0.031255383,-0.102283575,-0.087118015,-0.009962485,0.030659428,-0.05175456,-0.03489248,-0.032271072,0.088075474,-0.06261478,-0.08942313,-0.008217626,-0.03347298,-2.5830733e-33,-0.009515132,-0.09476759,-0.013407996,-0.015949355,-0.06444733,0.03232358,-0.10887045,-0.017631652,-0.025904486,0.011787705,0.028412223,-0.03247766,-0.014134885,-0.03399807,-0.029657818,0.016646042,0.038623642,0.07240988,0.056239087,0.018827904,-0.058482096,0.08421364,0.008167377,0.058871716,-0.02626965,0.020465598,0.0042580036,0.090947315,0.09943692,0.031027596,-0.028067902,0.044702798,-0.006496311,-0.008363388,0.037812416,-0.027051892,-0.009491891,-0.045743465,0.037040893,-0.028497212,-0.018052053,0.016317047,0.013417245,0.053459078,-0.0066490723,0.11427129,-0.13057812,0.010584557,0.0060356315,-0.0017390796,0.04021322,-0.03548747,-0.013171068,-0.010503689,-0.030645737,0.028799543,0.002120367,0.009845774,-0.025171481,0.021561546,0.001531928,-0.012912506,0.0020081769,0.019658027,0.065390274,0.06556559,0.042667303,0.16380374,-0.0044917576,-0.033242483,0.016475031,0.051444862,0.05703611,0.025452947,-0.05581395,0.05015304,-0.03729016,0.07172908,0.037277523,0.008065062,0.02563619,-0.010731455,-0.0030918256,-0.05099087,-0.026463205,0.0066489973,-0.023396235,0.05400151,0.00965991,0.005021102,0.0109609505,0.026196107,-0.028991286,-0.018741192,0.04277636,-2.8378693e-08,0.017112814,-0.11025009,-0.016979286,-0.06935882,0.04355863,-0.0063778483,0.07110269,0.0053801197,0.018204061,-0.010050463,-0.05836434,0.078959204,-0.0021035052,-0.014285772,0.027356308,0.028487757,0.027338307,-0.03869149,-0.020847103,0.036964785,-0.06602411,0.015852902,-0.081365295,0.010827485,0.01133253,-0.06123645,0.091548614,0.06247822,0.019275999,0.019293617,-0.01245365,0.024837416,-0.0039573703,0.015033495,-0.078227095,0.020584991,-0.009426974,-0.058729995,-0.09158185,0.104622975,-0.030756274,0.03403879,-0.039206833,-0.06367142,0.0027364297,-0.0301633,0.037953045,0.010033961,-0.0002761353,-0.03766133,-0.014061886,0.012728722,-0.076424055,0.006676121,-0.1356989,0.012509493,0.015658827,-0.01059018,-0.0018167635,-0.035878815,-0.03687614,0.04937118,0.1630131,0.08509065 +1.1.1.405,"Requires Zn2+. The enzyme, characterized in bacteria, is specific for NADP. It is part of the synthesis pathway of CDP-ribitol. In Haemophilus influenzae it is part of a multifunctional enzyme also catalysing EC 2.7.7.40, D-ribitol-5-phosphate cytidylyltransferase. cf. EC 1.1.1.137, ribitol-5-phosphate 2-dehydrogenase.",384,0.99999994,-0.06772136,0.016960315,-0.089312516,-0.014972771,0.038385905,0.058299884,-0.09331806,0.037072927,0.037670676,0.03312381,-0.040123284,-0.018960208,-0.04073457,0.056285404,-0.067962326,0.008213792,-0.037922427,0.015294252,0.009801449,-0.03365585,0.08922272,0.115752235,0.006049158,-0.06312472,0.04349427,0.008607112,0.025940249,0.0034339388,-0.021375375,-0.030097548,-0.020418482,-0.020916522,0.04914277,-0.07293861,0.027052928,0.08109759,-0.01306914,-0.0596708,0.04094049,0.0140694035,0.02665376,0.04161223,-0.011967617,-0.04058936,0.034471598,-0.012145991,0.07361927,0.08905183,0.00935644,0.005047109,-0.076938085,-0.029726474,-0.017067622,0.007254012,0.051355325,0.07338412,-0.033161543,-0.06803025,-0.015656631,-0.0386032,0.00016577406,-0.03993844,-0.007862121,0.010329362,0.0724529,-0.059601214,0.042271916,-0.04869038,-0.019391827,-0.0022349465,-0.12625487,-0.025717232,-0.011475574,0.051352017,-0.014938225,0.03486081,0.025750885,-0.085368656,0.07389728,-0.047068544,0.025738426,0.013111749,0.031495,0.08079705,0.056798052,0.072497964,0.014759951,0.0091585405,-0.011380909,0.04361942,-0.0041070906,-0.027067136,0.04342074,-0.019651221,-0.06918506,0.03507861,0.029586095,0.060611036,0.031282768,-0.043304052,0.04494478,0.06746923,0.06240435,-0.08949998,-0.045319714,0.011988352,0.014333295,0.113273166,-0.015148008,-0.008061184,-0.0422764,0.0009792552,-0.026286028,-0.09114914,0.035128266,0.10033809,0.013360675,-0.11220849,-0.08673614,-0.024721125,-0.01353198,-0.07944192,0.009538982,0.09807144,-0.034608223,0.019902725,-0.12076683,1.14479145e-33,0.059392083,0.039709263,0.027674142,0.031200664,0.008359387,0.028798288,-0.06962146,0.01631623,-0.025337776,-0.0280757,-0.07707713,-0.13260275,0.041820105,-0.015880302,-0.009135434,0.0052791447,-0.040449448,-0.020752259,-0.001086664,0.03396187,0.053594295,0.04268803,-0.00926197,0.029768854,0.06488746,0.077392794,0.0035894497,-0.02087756,0.047117863,-0.0413028,0.051335033,-0.074977085,-0.12286593,0.02284882,0.07903882,-0.027695768,-0.042739496,-0.021774044,0.025390344,0.047867585,-0.0097223185,0.054361913,-0.014300442,-0.006614839,0.07238334,-0.05664649,-0.028653776,0.057056755,0.014699856,0.05175355,0.07558823,-0.00830072,0.10217421,-0.0652916,-0.040802125,0.025030788,-0.045975685,-0.0053017503,0.056066707,0.07490127,0.0080033755,-0.009961805,-0.042003255,0.084145606,-0.03879045,0.06919599,-0.041671354,-0.08552604,0.046478573,0.07649105,-0.02417634,-0.012836038,0.06053662,0.0048408327,0.03026374,-0.057404935,-0.03659896,-0.030798007,0.08190223,0.027496638,-0.050947823,-0.03676662,-0.044605687,-0.016531356,-0.009495119,-0.032544322,-0.012040657,-0.0716903,-0.00796197,0.08635019,0.039824225,-0.06402061,-0.054681327,-0.009931897,0.051798407,-2.995871e-33,0.058645125,-0.058431607,0.011781591,-0.094879024,-0.07892532,0.08606869,-0.038809087,-0.13978249,0.015474655,-0.06806239,0.052184477,0.02717793,0.07591749,-0.034010015,-0.027851516,-0.020952132,-0.020050392,0.023612952,0.0041503925,0.0031065461,0.04910461,0.056727692,0.050994106,-0.026164962,0.047053754,-0.0015910638,-0.0415344,0.056413177,0.07535019,0.052471217,-0.070951566,0.037138477,-0.07873292,-0.051512524,-0.081928715,0.06214526,-0.06431801,0.045097917,0.0021741332,-0.021360872,-0.02616327,0.01946783,-0.03682263,0.09214425,-0.0065221707,0.089154534,-0.030036954,-0.026529726,0.0066586877,-0.053778175,0.0647243,0.011877128,-0.060000572,0.039730147,0.0021786608,0.06424523,-0.010893375,0.018158821,0.06810779,-0.030888597,-0.057201996,-0.038784187,0.0012240972,-0.036940914,0.06618751,0.0019177976,0.014362241,0.04726132,0.027756723,-0.045725875,0.08323607,0.045779224,0.03775123,0.03245011,-0.013071263,-0.056641694,-0.09436304,0.015105254,0.012410147,0.008252488,-0.019422343,0.0064046243,-0.012375839,-0.025104407,-0.018807936,-0.09586914,0.094137624,0.07806031,-0.008780174,0.017564578,-0.02365981,0.061836015,-0.0010057513,0.030485956,-0.071479104,-4.1977685e-08,0.03315433,-0.035464317,0.013181995,-0.11925678,0.01729953,0.06567855,-0.017626096,-0.0047360933,0.058472622,0.025957456,0.013674989,0.12701467,0.015959583,-0.0011269335,0.03854462,-0.022658141,-0.0594871,0.00212217,-0.022514492,-0.028442608,-0.06123148,0.012250802,-0.16448669,0.092365876,0.030368851,-0.08501957,0.011088592,-0.05621184,0.07225771,-0.059482407,-0.008929586,0.03047249,0.070777535,-0.05628143,-0.11187528,0.029001579,0.0004774328,-0.035029147,-0.026735758,-0.028343312,0.005283282,-0.032388154,-0.009966607,-0.011075044,-0.04717135,0.01554675,0.040720206,-0.028966313,-0.048822798,-0.008969214,0.016564889,-0.0344887,-0.003397139,-0.11261187,-0.09379027,0.02258038,0.034792762,-0.09046439,0.032701287,-0.007670731,0.0132932775,0.009348875,0.098458074,-0.0074350764 +1.1.1.406,"The enzyme, characterized in the bacterium Rhodobacter sphaeroides, has a wide subtrate specificity. In addition to galactitol, it primarily oxidizes D-threitol and xylitol, and in addition to L-tagatose, it primarily reduces L-erythrulose, D-ribulose and L-glyceraldehyde. It is specific for NAD+. The enzyme also shows activity with D-tagatose (cf. EC 1.1.1.16, galactitol 2-dehydrogenase).",384,1.0,-0.050270125,-0.054895565,-0.09168539,-0.00593485,0.05295008,0.036039058,-0.07040466,0.08194947,0.015449996,0.025989622,-0.01863828,0.016440406,-0.05318179,0.058737066,-0.048100244,0.028103562,-0.0014190817,0.04290173,-0.0004495381,0.026615351,0.11560083,-0.013374332,-0.015208979,0.025673224,0.119018316,0.01673583,0.03368898,-0.03475988,-0.12191708,-0.07497671,0.026961993,-0.03024634,0.09501789,-0.055890847,-0.00348237,0.08645619,0.0065924795,-0.010951134,0.09497743,0.03027814,-0.016204529,0.010775072,-0.009746041,-0.004437706,-0.076971166,-0.0064257565,-0.060398284,0.083290234,0.0069812206,-0.00028797594,-0.048143048,-0.03575029,-0.024609938,0.016063392,0.070543885,0.0927707,-0.017917894,-0.07978496,-0.012750001,-0.019499885,0.05062595,-0.036602486,-0.008741628,0.056382954,-0.0036232949,-0.11720869,0.044421624,-0.065503605,0.0040426506,-0.038423117,-0.052128814,-0.02841499,-0.0035767118,-0.007829843,-0.012159192,0.022454271,-0.014055137,-0.026765257,0.062629476,-0.04489616,0.024331043,-0.0018091244,-0.025407605,0.06830476,0.032122843,-0.027343072,0.046122577,-0.018076653,0.023232054,0.014000384,0.07168431,-0.015796531,-0.039196186,-0.05074871,-0.1255717,0.02229316,0.019282723,-0.01853593,0.006024117,-0.041428983,0.020775095,0.036799666,0.01692503,-0.09452102,-0.029008135,-0.013881711,-0.030786656,0.122412264,-0.0041212426,-0.05724194,0.067834616,-0.009716273,-0.0066397698,-0.0020441532,-0.044414528,0.09904111,0.123863146,-0.07374422,-0.13590634,-0.013566916,-0.012857172,-0.057501357,0.052302074,-0.031174166,-0.023013648,0.060919806,-0.097636305,2.0105468e-33,0.10634584,-0.019829344,-0.026446715,-0.04545383,-0.007521091,0.08034787,-0.124724336,0.031207217,0.020481085,-0.012791717,-0.020940987,-0.040660318,0.0552044,-0.007693573,0.009948794,0.10462035,-0.036659103,-0.04069467,0.014896934,0.053260665,0.0075462377,0.039555784,-0.03960053,0.018440433,0.07053368,0.08666518,-0.019258369,-0.044572648,0.02167704,0.020567471,0.056967374,-0.087557115,-0.10958082,0.07789955,0.021794345,0.029467339,-0.08679097,-0.053528994,0.034424763,-0.015797714,-0.06180638,-0.011020899,-0.022125443,-0.07522538,0.02374791,-0.0540573,0.0054508443,0.051916987,0.013793614,0.12708627,0.07496896,-0.043230407,0.08794149,-0.03242363,-0.0493739,0.06649001,-0.03611179,0.045192383,0.084587276,0.08615581,0.017309958,0.04281713,0.008350962,0.03007921,0.029969301,-0.028845765,-0.007938971,-0.05672665,-0.025930747,0.053042516,-0.03423509,-0.044632524,0.10686832,0.026573371,0.0056602443,-0.044942025,-0.02822418,-0.012526002,0.05877361,-0.011669798,-0.013018797,-0.0051355655,0.007947055,0.004022315,-0.02049071,-0.016911415,-0.04052643,-0.055713188,-0.010074505,0.033535864,0.060222555,-0.05709766,-0.10604699,-0.014344235,0.035323873,-2.9989598e-33,0.104181476,-0.09267416,0.02106778,-0.069065265,-0.012260011,0.06694102,0.036097497,0.017744174,-0.018504795,-0.055548288,0.07165992,0.013781037,-0.094597,-0.01385538,0.053101104,0.016548486,-0.03196194,0.0010844093,-0.048850533,-0.0062552732,0.026120357,0.10097789,0.05202293,0.033107903,0.08677686,-0.059440825,-0.058829438,0.06274426,0.03562797,-0.0020765583,0.003665403,0.055035405,-0.04989429,-0.06841808,-0.020007512,0.0068507683,-0.067641616,0.057684004,0.064441524,0.038021065,-0.020366626,0.035462115,0.017608227,0.05873381,0.058834355,0.028704327,-0.092205696,-0.04796428,0.032157328,-0.07026496,0.0021367227,-0.03280554,-0.018078707,0.043338865,0.005702408,0.032947514,-0.015599862,0.023708528,-0.03905033,0.0018021562,-0.08341459,-0.049983986,0.0693066,-0.0015583606,0.034248576,0.05706356,-0.012507002,0.05447389,-0.015940288,-0.023514366,0.116381586,-0.04362989,-0.0011432745,0.067146964,-0.026377717,-0.069416605,-0.083257385,-0.01627505,-0.009478561,0.016007897,0.06276033,0.013076288,-0.034691043,-0.03343291,0.0152506,-0.05227007,0.007624077,0.08190229,-0.058094136,0.00030821306,-0.02353523,0.04666968,-0.032256324,0.032954402,0.08518914,-4.154934e-08,0.04481456,-0.06547126,0.04492634,-0.07272899,0.06494743,0.022469122,0.011997243,0.012354161,0.026826737,-0.020447394,-0.00017494126,0.11234699,-0.008497032,0.0294355,0.03669115,0.04601222,-0.045273617,-0.01104737,-0.049040347,0.052438155,-0.04593362,-0.018120121,-0.14476728,0.028880496,0.011701085,-0.027481278,0.05319001,-0.028434146,0.03627657,-0.032933436,0.04641398,0.034689285,-0.00023323395,0.03949433,-0.10112034,0.035209987,-0.031152574,-0.052945998,-0.036565386,0.058623526,-0.025391394,-0.054130103,-0.054202955,0.0049604625,0.0071938843,-0.011216829,-0.035206348,-0.011477419,-0.020778982,0.02511275,-0.004255762,-0.033673614,-0.0375138,-0.08191196,-0.092606194,0.08638687,0.026320038,-0.070462726,-0.013333168,-0.027303902,0.04167715,-0.011235251,0.104986005,0.01224357 +1.1.1.407,"The enzyme, characterized in Agrobacterium fabrum C58, also has low activity with D-mannitol and D-arabinitol. It is part of a D-altritol degradation pathway.",384,1.0,-0.01925299,-0.084578484,-0.045784708,-0.03090914,0.015272131,0.04769115,-0.076116465,0.0842272,0.054112893,0.06914993,-0.017314808,-0.01355643,0.010218951,-0.03149357,-0.048514407,0.055731937,-0.030114215,0.035731252,-0.1042092,-0.012192982,0.035154227,0.03213049,-0.00067610975,-0.07130627,0.051347043,0.004013455,0.012204833,-0.008573951,-0.061690107,-0.100881435,0.0060148984,0.0416462,0.10415841,-0.012198836,0.07831182,0.11198174,0.028220126,0.006355263,0.09211304,-0.0394407,0.023863045,-0.012369702,0.037263285,0.014135846,-0.033568665,0.034111235,-0.07115659,0.018046523,0.039984,-0.026248774,-0.03709109,-0.0368203,0.004247695,-0.0030247308,0.014896461,0.06472166,0.019282186,-0.059141174,0.011410976,0.016136363,0.025014224,-0.033442095,0.04268299,-0.010979509,0.048588574,-0.039780643,0.0062448834,-0.11627147,0.008850388,0.013209145,-0.08437983,-0.049883746,-0.018996896,0.050154176,-0.0074215736,-0.014874861,-0.068322286,-0.06114396,0.06714401,-0.048518635,0.038141478,0.033345614,0.024020042,0.047954444,-0.040368885,-0.01722646,0.03191769,-0.06845119,0.09875862,0.044979293,0.032924354,0.03132612,0.014207613,-0.054010235,-0.04859399,0.021138035,0.026839642,-0.021829156,-0.043770768,0.001766108,0.017992686,0.030702006,-0.04397388,-0.074929155,-0.07291656,-0.05512334,-0.031360187,0.08534897,-0.05993461,-0.017010823,0.019417794,0.0026971353,-0.0025111805,-0.04172926,-0.09538124,-0.033065673,0.06729478,-0.09938195,-0.06003255,-0.051854655,-0.03847109,-0.02949532,0.06508277,0.040034454,0.02815586,0.007813559,-0.07573216,4.7524144e-34,0.064435475,-0.08866261,-0.0040833363,-0.010518323,0.029785864,-0.025401631,-0.07889386,0.006909939,-0.012432339,-0.010507367,-0.0826594,-0.03500221,-0.027339714,-0.007575881,-0.0047010994,0.10434813,0.002222152,-0.045341346,0.031906232,-0.049586874,0.06175351,0.048832625,0.011535054,0.03648371,0.05181318,0.08517214,0.060556117,-0.023016443,0.0116953645,0.0061141653,0.006067577,-0.052522887,-0.07674677,0.0054542706,0.04195853,0.03612081,-0.08528819,0.058503672,-0.048946165,0.09274942,0.0053147078,0.044285037,-0.009435167,-0.028235277,0.08044489,-0.009978119,0.031141147,0.10087119,0.006795895,0.10694978,0.09101088,-0.052950457,0.0636001,0.02331609,-0.030059095,0.025757961,-0.04950368,0.023742788,0.00014630223,0.070672564,0.015575261,0.05166885,-0.036628783,0.044840585,-0.030968163,0.013858055,-0.08748892,0.0066469307,0.047919925,0.055101536,0.02058451,-0.02270933,0.065456696,0.05328735,0.0338018,-0.030188717,-0.04150513,-0.036370106,0.025880527,-0.0057532447,0.024934672,-0.056161802,-0.01857635,-0.0031626474,-0.10558736,0.002373092,-0.08936298,-0.07346808,-0.06781,-0.011452919,0.045045376,-0.06373687,-0.13547298,0.11025623,0.0464345,-1.946691e-33,0.05907593,-0.07958797,0.079813376,0.023737036,-0.027230196,0.020310266,0.037561644,0.012157793,0.016188977,0.0032706289,0.07449306,0.033897597,-0.025290016,0.0049798456,0.011397354,-0.019828105,0.0027410449,0.008548998,-0.053374894,0.03631304,-0.08615238,0.08145359,-0.001404336,0.0031057661,0.056947194,0.027486233,-0.04789944,0.107607804,0.0020014518,0.033313908,0.05602856,0.072426125,0.006502793,-0.0002646598,-0.0931405,0.010838249,-0.05112149,-0.0042497516,-0.06406058,0.00804057,-0.061417665,0.059669618,0.021231903,-0.02016645,0.03728447,0.034873348,-0.0830691,0.0006392344,0.04039524,-0.054165345,0.026377268,-0.067454234,0.0265743,0.034300297,0.024081247,0.08068831,0.02252305,0.047200445,-0.059084535,0.040633664,-0.006073313,-0.070541956,0.082357295,0.039724465,0.09064427,0.1064476,0.029882137,0.13853852,0.004160221,-0.011899939,0.09723681,0.049610715,0.00030022764,-0.012773552,0.03383297,0.016374711,-0.066201754,0.02466262,-0.0056239893,-0.0038278673,-0.05743829,-0.0068151597,-0.06659719,0.00019529372,-0.0833461,-0.021381855,-0.002038584,0.058241762,-0.032016307,0.10562746,-0.10690963,0.009034576,-0.046757214,0.066440105,0.04893035,-3.1571147e-08,0.006623392,0.0067211455,0.007540048,-0.06422725,0.08879053,0.0445046,-0.062932424,0.07093834,0.062768586,-0.009586794,-0.11607122,0.08644637,-0.053983927,0.03562593,0.039976705,-0.0055932584,-0.03821326,-0.039738506,-0.03218864,-0.0067007407,-0.0874173,-0.03506045,-0.08303565,0.0044400245,-0.015124575,-0.08204261,0.05476448,0.024276473,-0.012161931,-0.0040009017,-0.012710606,0.03022104,-0.016804185,-0.056377456,-0.08957447,0.04657437,-0.037302677,-0.115185104,-0.05641447,0.046134777,0.009221669,-0.0021436054,-0.06801064,-0.014398241,-0.0315485,-0.020698663,-0.027185585,0.008622484,-0.016266422,0.0071819345,0.044965714,0.016598422,-0.10648295,-0.019097352,-0.09903471,0.027523886,0.023954611,-0.09081576,-0.010467057,-0.0009672489,0.025675643,-0.07782185,0.06965038,-0.02213379 +1.1.5.12,The enzyme is an FAD-dependent peripheral membrane dehydrogenase that participates in respiration. Electrons derived from D-lactate oxidation are transferred to the membrane soluble quinone pool.,384,1.0,-0.10534788,-0.03939086,-0.057452608,-0.059888557,0.06869174,-0.039439958,0.009170402,0.07978238,0.02008495,0.03660461,-0.016754469,-0.023554653,-0.09199933,0.045053907,-0.04969719,0.029139873,-0.06984137,0.0065100715,-0.038250636,-0.04674325,0.065022215,0.017462578,-0.044064697,-0.0740781,0.08997198,0.0006207347,0.0813702,-0.03775631,-0.033069335,0.023821838,-0.018720312,0.0033802702,-0.027837731,0.0001972999,-0.056070805,0.14561202,0.031265173,0.0014376626,-0.011199371,0.021581234,0.01673025,0.011252778,-0.018887918,0.012911642,0.0069930134,0.035774115,-0.018846784,0.06528354,-0.042382702,0.014281286,-0.008883312,-0.02777565,-0.03774876,0.055181503,0.0127124665,0.09310651,0.024802145,-0.014916669,-0.042354703,0.012082979,-0.011504182,-0.0055053416,0.015566761,0.03803942,0.02593849,-0.062654205,0.034507364,-0.029537447,0.016252916,-0.1105192,-0.035766587,-0.04860946,-0.027451962,-0.114669025,-0.012202142,0.005081243,-0.0041138083,-0.05594101,0.09646936,-0.028431753,0.09217357,-0.00871195,0.053401966,0.07974196,0.061461512,-0.0393253,0.07755203,-0.04989784,-0.00746789,0.029538605,-0.04028783,-0.020236531,-0.031370185,-0.03583988,-0.11684658,0.07149266,0.011259264,0.03304601,-0.0503255,-0.013451595,-0.02566013,0.06839647,-0.02209542,-0.029381318,-0.09514341,-0.04725885,0.024864586,0.09262796,-0.037412956,0.00022288253,0.018464291,0.021610072,0.08116447,0.08298127,0.019433975,0.123113744,-0.006066355,-0.07414396,0.033599027,-0.038274497,-0.05278954,0.03519247,0.012739151,0.052115317,0.040191114,0.035296105,-0.039389372,1.1143451e-33,0.03545924,-0.03939526,-0.042638857,-0.019910991,-0.024471015,-0.061196517,-0.10539274,0.020455105,-0.055254847,-0.021521362,-0.057336975,-0.030746391,0.03095134,-0.013344591,-0.018306945,0.007711779,-0.049857855,-0.02052515,0.09542664,-0.04765602,0.047598813,0.074223444,-0.006114965,-0.02471679,0.05757155,0.0014223633,-0.043024078,0.11811806,0.019416954,-0.00090261194,0.043234494,-0.108650185,-0.03934172,-0.009541286,-0.037095536,0.03561824,-0.062168814,-0.008626332,-0.0699551,0.04555742,-0.0006042275,0.03785682,0.020612286,-0.041083224,-0.007015828,-0.095845,-0.020800546,0.061562557,0.06429596,0.02230799,0.045201596,-0.04772198,0.06806916,-0.086948946,-0.08300088,-0.027456086,-0.053172227,0.015067624,0.043259073,0.05145576,0.04687191,0.04018331,-0.054494448,0.11345095,0.08687806,-0.0022288389,-0.038756564,-0.09074247,0.032178067,0.08425085,-0.07803299,-0.0519615,0.11602273,-0.057239156,0.022762835,-0.05030837,-0.006590079,-0.0037565199,-0.017256591,-0.008932313,0.07647026,-0.0653151,-0.031083131,-0.027946096,-0.0117942905,-0.04646509,-0.059183903,-0.065927304,0.0011190642,-0.02361796,0.04488976,-0.045476753,-0.05718448,-0.00593085,0.099095084,-1.64215e-33,0.025334015,-0.06781482,0.030818217,-0.050202366,-0.017173976,0.14693007,0.055977643,0.023146126,0.036060933,-0.069920644,-0.008427248,-0.010963324,0.015718255,0.010055338,0.031292133,0.00899012,-0.10022914,-0.06900332,0.016676096,0.026849521,0.021465648,0.1339322,0.03556078,0.05646602,0.039370757,0.040056832,-0.03890526,0.03067052,0.019589504,0.015925733,-0.019441172,0.0027719433,-0.020782985,0.021610934,-0.056761473,0.01909905,-0.05505187,0.02183429,-0.007156274,0.03077597,-0.015559324,0.01117443,0.06992728,0.056472592,-0.0015618976,0.052029483,-0.094323345,-0.051330075,-0.023728952,-0.058403067,0.00021370532,0.047879342,-0.055325985,0.022653034,0.055475615,0.10402578,0.030229883,0.03598758,0.006195183,-0.02406972,0.007949998,-0.09065964,0.03544854,-0.06986524,0.022750635,0.03379241,-0.05868907,0.0653801,0.016497668,-0.012690653,0.10072087,0.056676753,-0.044634618,0.033707384,-0.05278892,-0.062283054,-0.042999834,0.032735415,0.015544571,0.052524943,-0.013579709,0.0609863,-0.076462984,0.045074172,-0.043980528,-0.097307116,0.0090195965,0.08949095,0.029546972,-0.0026348105,-0.026093828,0.011890667,-0.053016093,0.043685887,0.089473344,-2.8857423e-08,0.0072270078,-0.048597872,0.058631524,0.01991407,-0.018881459,-0.01699179,0.06324649,0.039278783,-0.003986382,0.004496645,-0.01105156,0.119202554,0.027397912,-0.0031944315,0.09993929,0.058087815,-0.028606689,-0.012446798,-0.05596498,-0.021181662,0.010253205,-0.051603816,-0.10123114,0.038012017,0.003705149,-0.045347102,0.035737712,0.023849847,-0.056894753,-0.031009587,-0.036166232,0.041603748,0.020981573,-0.036262825,-0.06417499,0.04826004,0.008366885,-0.026816195,-0.05737266,0.030026294,0.0039071287,-0.056102563,-0.04045538,0.01262297,-0.003455551,0.04100527,0.021399401,-0.018565891,-0.009269759,0.08546057,0.028766498,-0.04393065,0.025515152,-0.048378956,-0.07768271,0.014295479,-0.07855085,-0.06767402,-0.004384521,-0.0076243635,0.08326026,0.059826877,0.14648357,-0.06197313 +1.1.98.6,"The enzyme, which is expressed in the bacterium Escherichia coli during anaerobic growth, contains an iron sulfur center. The active form of the enzyme contains an oxygen-sensitive glycyl (1-amino-2-oxoethan-1-yl) radical that is generated by the activating enzyme NrdG via chemistry involving S-adenosylmethionine (SAM) and a [4Fe-4S] cluster. The glycyl radical is involved in generation of a transient thiyl (sulfanyl) radical on a cysteine residue, which attacks the substrate, forming a ribonucleotide 3'-radical, followed by water loss to form a ketyl (alpha-oxoalkyl) radical. The ketyl radical gains an electron from a cysteine residue and a proton from formic acid, forming 3'-keto-deoxyribonucleotide and generating a thiosulfuranyl (1lambda4-disulfan-1-yl) radical bridge between methionine and cysteine residues. Oxidation of formate by the thiosulfuranyl radical results in the release of CO2 and regeneration of the thiyl radical. cf. EC 1.17.4.1, ribonucleoside-diphosphate reductase and EC 1.17.4.2, ribonucleoside-triphosphate reductase (thioredoxin).",384,0.99999994,-0.027790561,-0.066706784,-0.09933642,0.098493285,0.03286227,0.037614707,-0.109344326,0.042753864,0.0750672,0.011363478,0.0013825113,0.03074751,-0.0095347725,0.08887204,-0.040509783,0.051248316,-0.09501228,0.08580811,-0.06510337,-0.07330275,0.04100206,0.006595922,-0.04908668,-0.0045186137,0.014496397,0.0027075168,0.11522689,0.010454482,-0.09279544,-0.0283821,0.01322967,-0.039483093,0.08338203,-0.028929994,0.06346694,0.11593322,-0.018750202,-0.024305347,0.075287394,-0.05170296,-0.054970123,0.01670063,-0.017092925,0.011997883,0.007093244,-0.025016483,0.028927587,0.060573384,0.02120932,-0.066186756,-0.037434753,-0.02052035,-0.02091537,-0.0072708884,0.031737294,-0.01507399,-0.036076017,-0.05302557,0.038599767,-0.0064534256,0.04871296,-0.049436316,-0.036177155,-0.065852985,-0.05539377,-0.054162633,0.10304037,-0.049358252,0.05083994,-0.03732091,-0.08002809,0.010371055,-0.03273984,0.030129714,-0.061103433,0.0005729531,0.03364429,-0.057673607,0.07650912,0.003811578,0.04988313,-0.022335846,0.040448297,0.05224818,0.0705424,0.040067285,0.036618132,-0.03206162,0.036473516,0.04163887,0.002636648,0.028067116,-0.019231552,-0.0888525,0.0007968909,-0.0301809,-0.006463745,0.025702085,-0.014760914,0.004352581,0.023864605,0.08729774,-0.040117666,-0.062483083,0.008512972,-0.021413323,0.016777808,0.14777909,-0.035446703,0.035118647,0.021274298,0.04832834,0.0052289823,0.0028832664,-0.023141304,0.12020036,0.062954195,-0.056666233,-0.099257365,0.03698317,0.0454125,0.011218409,0.011515289,0.04354062,-0.034101006,0.0013484468,-0.08466541,4.965657e-33,0.07831485,0.098223835,-0.0030746213,-0.025094626,-0.0027322224,-0.07277025,-0.11526421,0.0058839386,0.022869019,0.017071635,-0.03960619,-0.05135214,0.096910276,-0.08288281,-0.04433943,-0.045614377,-0.07220637,0.024600359,0.001647212,0.05328814,-0.0787595,0.011671165,0.026906982,-0.0127644,-0.020644493,0.036490656,-0.0018978938,-0.019921059,0.00351545,0.012026539,0.016630035,-0.049461957,-0.11212747,-0.010933802,0.046652798,0.006387921,-0.04484994,-0.036627468,0.03387096,0.09879501,-0.0482482,0.06646571,0.0089099845,-0.021949498,0.044286564,-0.017098323,-0.06785421,0.12005272,0.053155754,0.05213402,0.05976893,-0.013825539,0.12889025,-0.04443805,0.0017402803,-0.025230864,0.047960136,-0.013144141,0.061192106,0.063612826,0.0317812,0.028233593,-0.063358285,0.0388059,-0.023808982,-0.0074744653,-0.065639764,-0.0035242848,-0.0032317075,0.09280399,0.011578511,0.016502282,0.053748418,0.023536295,-0.0822074,-0.05088383,-0.027647955,0.091075,0.02511853,0.02363514,-0.0386464,-0.04917162,-0.050209958,-0.045249194,-0.039489437,0.0346407,-0.04219735,0.0028449458,-0.016417775,0.0089933155,0.026384028,-0.07503466,-0.01452536,-0.010824363,-0.00049522304,-5.3959555e-33,0.06419951,-0.042685203,-0.051079534,-0.053736776,-0.030800732,0.062546164,-0.031317316,0.0044059292,-0.011511114,-0.06395429,0.07240315,0.02062118,-0.025721066,-0.014365496,0.054929085,-0.045244228,0.05345655,0.03032601,-0.05284927,0.012303289,0.03575188,0.052612826,-0.004741827,0.0040116124,0.08366839,0.03643158,-0.027658926,0.047401294,0.04013392,0.09369386,0.05132938,-0.024909027,-0.019134244,-0.0465381,0.01773033,0.101030774,-0.0121545475,-0.0038933335,0.02085763,0.025502658,-0.004468412,0.063437074,0.0072508613,0.16612086,0.0005167911,0.051666252,-0.045177042,0.0041209473,0.03287887,-0.111692674,0.048190057,-0.050909907,-0.010554418,0.0032802746,-0.032325625,0.057138022,0.008512296,-0.010146594,-0.054955665,0.012756339,-0.08450523,-0.109913394,0.023461338,-0.09127342,0.0026503906,-0.018303417,-0.047714338,0.017543552,0.027637528,0.006887759,-0.04358389,0.003848376,0.029228492,0.02807425,-0.034164708,-0.017694976,-0.04678106,0.039646663,-0.04638634,0.03884301,-0.02062488,0.05075531,-0.07745064,-0.061957173,0.031566728,-0.13508943,0.031569526,0.10255828,-0.024910377,-0.0312052,-0.030792987,-0.002599854,-0.028553553,0.030956006,-0.006012124,-5.174933e-08,0.0139692705,-0.07792838,0.033837784,-0.012875236,0.054197963,0.08302691,0.03525836,-0.0051099868,-0.010173934,-0.049784694,-0.018986864,0.18350658,0.0046786796,-0.021572843,0.017766763,0.0069480236,-0.076885685,-0.015948378,-0.017852565,-0.027931718,-0.04446952,-0.045761373,-0.11997629,0.02134595,-0.00093600573,-0.053601984,0.0466681,-0.043965396,-0.046013206,-0.015003688,0.049689922,0.022068013,-0.0034588608,0.027345765,-0.11258838,-0.013322993,-0.06013655,0.033909783,-0.012390781,0.020895166,-0.049698208,0.00911247,-0.12649693,0.063060015,-0.04076593,0.0009485418,-0.021562848,0.013546757,-0.08274931,0.004430079,0.030875823,-0.036054708,-0.0051134657,0.004949763,-0.056144785,0.04449413,0.014771684,-0.0781445,0.07108647,-0.0051847855,0.016867783,-0.010514702,0.09313004,0.008483142 +1.1.99.40,"The enzyme, characterized in the yeast Saccharomyces cerevisiae, also functions as EC 1.1.2.4, D-lactate dehydrogenase (cytochrome), and is active with oxaloacetate as electron acceptor forming (R)-malate. ",384,1.0,-0.0128968125,-0.045469414,-0.010270414,-0.035344735,0.053935163,0.026516838,-0.04114175,0.05044154,0.029160962,0.009305418,0.03091246,-0.041390885,-0.10673099,0.018599294,-0.049270876,0.0037768765,-0.040870693,-0.014170672,0.040500697,-0.019684428,0.07001436,0.07626326,0.04321223,0.010057816,0.06676234,-0.02414818,0.065650485,0.0338716,-0.051186934,-0.09945261,0.019453578,-0.054522574,0.06921184,0.04244118,-0.07849046,0.07747939,0.039479278,-0.095878854,0.024155183,0.01883389,0.0077479896,-0.0016021008,-0.08257904,-0.035772316,-0.009645698,0.013726611,0.009198549,0.0063343514,-0.00025202284,-0.04274852,0.00019714012,-0.04828292,0.0044056578,0.048781846,0.009728761,0.04889188,-0.0029579347,-0.07334659,-0.03151678,-0.033330474,0.0063060657,-0.030175062,0.05292612,0.06441056,0.016093325,-0.07298574,0.068861164,-0.058813177,-0.029519076,-0.07936411,-0.11674212,-0.10128264,-0.058587115,0.0075952713,-0.0044639227,0.034791246,0.020227991,-0.10879663,0.04724455,-0.01799419,0.047618706,-0.019656816,0.020464687,0.010038568,0.05593219,-0.026552757,0.061695818,0.0032639888,0.06715547,0.029376162,-0.02700072,-0.007451762,-0.03068951,0.014107645,-0.049168017,0.025861604,0.06456707,0.12917,0.034000594,-0.030258847,0.05200903,0.13500498,0.010486197,-0.033505913,-0.02163142,0.02153585,0.040526953,0.065428935,0.014541932,-0.052431963,-0.019994715,-0.079314366,0.015939822,0.0752103,-0.043017793,0.03751178,0.052028608,-0.040265966,-0.032798264,-0.048637863,0.019500386,0.018560914,0.013625806,0.032029614,-0.031008933,0.049313076,-0.10116314,4.584867e-35,0.04882182,0.014700501,-0.046384726,-0.013956082,-0.005765992,0.015157141,-0.10298306,0.039641168,-0.061979994,-0.028030006,-0.06978198,0.032913852,0.046769362,0.059251793,0.0036378992,0.019783625,0.036148526,0.012172351,0.06726237,0.013513161,-0.015408405,-0.0028901019,-0.054703932,-0.032935087,0.065902755,0.04747574,-0.005977527,0.05807697,0.001041424,-0.015328001,-0.023286503,-0.0938597,-0.04933863,0.062781684,0.029916828,-0.023675997,-0.022532756,0.0034286566,-0.0010260654,0.0044698943,-0.0013169214,-0.004020205,-0.0037133624,-0.014842857,-0.018505951,-0.022363698,-0.05701289,0.075321645,0.058464978,0.08849267,-0.004121892,-0.034869023,0.0827028,-0.055466704,-0.0078607155,0.07455257,-0.083742484,0.030375885,0.017572824,0.047009695,-0.057566024,0.07722036,-0.024090987,0.08936408,0.0270225,-0.019928567,-0.05680133,-0.074308366,-0.024111293,0.04647699,-0.081087984,-0.011424244,0.066095255,0.015189213,0.01747802,-0.045973852,-0.08691504,-0.060529932,-0.041740824,0.041241094,-0.008072329,-0.06533584,-0.020672206,-0.019162431,-0.03211719,-0.017127749,0.007420268,-0.0060944967,-0.0041244896,-0.022008114,0.0104036555,-0.06260291,-0.03769802,0.014337747,0.08886951,-2.9643765e-33,0.10918776,-0.019571654,0.026997017,-0.069524534,-0.05383325,0.12096131,0.030597763,-0.03157968,0.0030141205,-0.051669277,0.05991076,-0.017959967,0.032564487,-0.07758407,0.02609101,-0.008700776,-0.06879045,0.0061783316,-0.0376816,0.044263765,0.02859865,0.07814001,-0.032653768,0.042559564,0.084616266,0.018464895,-0.0015219525,0.041316587,0.015671864,-0.037032787,-0.04700306,0.046882454,0.034437716,-0.0589639,-0.01344593,0.05812326,-0.012353332,-0.019158741,0.022117643,0.07355956,0.008408017,0.096435346,-0.02351446,0.048848912,0.034396224,0.11148994,-0.047663677,0.010813099,0.026838176,-0.05542053,-0.003978785,0.03741959,0.035893325,0.05312632,0.090882875,0.07508871,-0.039945543,0.052926973,-0.030931834,-0.03124618,-0.04113874,-0.07170151,0.077893995,-0.029022356,-0.022720704,-0.0438329,-0.08313919,-0.0139511395,0.033762008,-0.005090688,0.083105884,0.028011514,-0.030655073,0.01634763,-0.053498756,-0.057687808,-0.08781225,-0.06561447,-0.021152213,-0.00910329,0.056083582,0.0015951507,0.029203128,-0.059495583,-0.036465812,-0.07886742,-0.02148964,0.08445953,-0.06621319,-0.023850424,-0.022993112,-0.019758558,-0.103189826,0.08573265,0.039534505,-3.729342e-08,0.03432873,-0.03426777,0.057018913,-0.106775634,0.072983906,0.035740867,0.07521795,-0.035621174,0.019719802,-0.022096988,-0.028816048,0.11392179,0.02888625,0.014715183,0.051899873,-0.0022766981,-0.03388238,0.068691455,-0.017894702,0.08636477,0.01341789,-0.033774063,-0.160257,0.04536827,0.0065978607,-0.07947668,0.045554716,0.03716611,-0.012177285,-0.029057536,-0.0007718024,0.06397994,0.061021026,-0.04051635,-0.065657966,0.0047390033,-0.04592469,-0.058380682,-0.055241827,0.027159533,0.041545287,-0.07305596,-0.07139952,-0.001316762,-0.03928455,0.0120232,0.03246063,-0.014241255,-0.018044544,-0.046556003,0.05692239,0.00077337684,-0.015855623,-0.05548385,-0.08613867,0.04766468,-0.03615535,-0.086237386,-0.041514236,-0.09047122,0.042850655,-0.05280426,0.1839464,-0.1002294 +1.3.8.13,"The enzyme has been purified from the bacterium Escherichia coli O44 K74, in which it forms a complex with EC 2.8.3.21, L-carnitine CoA-transferase. The electron donor is believed to be an electron-transfer flavoprotein (ETF) encoded by the fixA and fixB genes.",384,1.0,-0.12474222,0.013755931,-0.06716857,0.02090083,0.0678065,-0.0014549587,-0.067410536,0.05671516,0.003077887,-0.061957166,0.023761272,-0.09221753,-0.048343986,0.019344633,-0.104613446,-0.017803011,-0.071916305,0.008947317,-0.026729845,-0.033710457,-0.021398567,0.034729533,0.01121959,-0.053144217,0.024988675,0.06232383,0.02100934,-0.04757302,-0.021509437,-0.10409361,0.016180174,-0.02943235,0.05918071,-0.047141787,0.014408354,0.06258128,0.004691051,-0.12512097,0.02905754,0.008100793,0.07237765,-0.02025552,0.027669633,-0.037046727,0.028345093,0.0012468837,0.06662178,0.021133354,0.0522922,-0.014836655,0.011862891,-0.053538926,-0.050337676,0.071164764,-0.0011878752,0.014982502,0.026282871,-0.053181298,-0.024577906,0.11414349,0.071879216,0.019900018,0.049750805,0.010704208,0.03354712,-0.07847911,0.033508904,-0.04689796,-0.0001728465,-0.098980516,-0.03015852,-0.039259966,-0.031117618,0.02116916,0.03999322,0.028347053,-0.018019466,0.020125326,0.060814764,0.046452984,0.03129134,-0.09463379,-0.020697316,0.088118754,0.031558808,-0.003514543,-0.027289918,0.0008480454,0.011038052,0.038663674,-0.015546408,-0.011996779,0.016446078,-0.03262551,-0.06951904,0.053693466,0.052075572,0.05064628,0.032203723,0.00097424875,-0.0016390542,0.071213186,0.016826166,-0.032870967,-0.08718943,-0.053982947,0.018426146,0.14182368,0.000989497,-0.061835203,0.022025323,-0.009319945,0.052073367,-0.03574215,0.0053724996,0.09755006,-0.06863498,-0.048633702,-0.0044110483,0.006880771,-0.00090871693,0.0052595683,0.056963526,0.09978184,0.023179563,0.04482359,-0.13328949,1.2333154e-33,0.05950361,0.07621314,0.004572905,-0.009813768,-0.003766186,-0.03209623,-0.06064371,0.026937945,-0.047880113,-0.060693327,-0.062139142,-0.058269516,0.06772948,-0.016688721,-0.05191512,-0.015049047,-0.044096936,-0.06539559,0.027463181,0.008942915,0.09352313,-0.01163741,0.0033963188,0.050754115,0.057637934,0.04329441,-0.017106468,0.027617602,0.06393635,0.020552585,-0.029785134,-0.031392466,-0.078903005,-0.037233915,0.0060092015,-0.07968883,-0.040322777,-0.087173,-0.02345501,0.024632247,0.012875539,0.05598301,-0.01042364,-0.004879201,0.067817025,-0.0076283566,-0.028780282,0.05122394,0.06570741,0.08042977,0.027941955,-0.0751726,0.049348146,-0.092635706,-0.09113581,0.081836745,-0.01862408,0.044018447,-0.012611262,-0.002238904,0.0423849,0.13857973,-0.020516926,0.040542755,-0.029429039,0.08594208,-0.008453608,-0.08619242,0.012325478,0.05129542,-0.07761116,0.019381924,0.047231752,-0.02118636,0.08009869,-0.03755151,-0.13667715,0.005934953,0.04428408,-0.02349184,0.036316965,-0.036342315,0.056382343,-0.054464057,-0.013176304,-0.04758001,-0.032608625,0.012909165,0.007909862,0.059475,0.0977553,-0.058927376,-0.012890712,-0.037670474,-0.009110169,-1.2155526e-33,0.06943162,-0.11057645,0.0040381933,-0.044563662,-0.052497834,0.036425103,-0.0314682,0.00092659215,0.1068769,0.04652679,0.075827554,-0.0061500636,0.057858787,-0.0796427,0.08117754,-0.014219488,-0.06006341,0.014871175,0.0016693505,-0.004234891,0.024437686,-0.04601228,0.08953044,0.004902998,0.08542462,-0.0008167105,-0.02497457,0.018832019,0.09142198,-0.032993026,-0.03875917,-0.048559226,-0.050941724,-0.016568245,-0.050005127,0.016707798,0.01996392,0.0245598,0.07659278,-0.012001581,-0.035466257,-0.0031903738,-0.018611686,0.08160309,0.026279138,0.05987443,-0.036601074,0.033585273,0.0358337,-0.033559136,0.027319085,0.00240569,-0.031434204,-0.023982912,0.02261537,0.06163576,0.08436652,0.014168487,-0.05966067,-0.04397442,-0.01596194,-0.11751171,0.024476083,0.008717989,0.06338312,0.04933666,-0.01483281,0.06276868,-0.01196337,-0.047012202,0.122632585,-0.02252739,-0.00016797737,0.023767304,-0.0029635276,-0.02234779,-0.03934508,-0.0028177588,0.005730301,-0.0075485734,-0.02095601,-0.044927876,0.016557915,-0.02770907,0.04855069,-0.07784161,0.027776955,0.10182184,0.041683204,0.009824044,-0.08140977,0.023279471,-0.029985592,-0.000616491,0.051472448,-3.664913e-08,0.031808786,-0.07632208,-0.07606471,-0.039053902,0.09664009,0.02638846,-0.09353076,-0.0025900975,0.037957042,-0.019108659,-0.017222585,0.13362843,0.006468742,-0.002356463,0.02986605,-0.038391277,0.0011499147,0.0012566979,-0.016938666,0.05411497,0.021632632,-0.041382335,-0.07569721,0.027263314,-0.0034250084,-0.058264986,0.011002572,0.029024135,0.0015229131,-0.077332795,-0.05473322,0.0016758865,0.012925334,0.0067081405,-0.09091067,-0.034963,0.036912218,-0.045441933,-0.047483526,0.065681934,0.072742015,-0.0013181374,-0.075847,0.00048929756,0.0034349433,0.075424045,0.0307221,-0.023831008,-0.0040460406,-0.029551504,0.030574346,-0.019780476,-0.040715225,-0.011009937,-0.10193335,-0.0033859864,-0.034042403,-0.061892517,0.060962934,-0.046967074,0.010453633,0.030343002,0.17826952,-0.009793719 +1.3.99.38,"The enzyme from the bacterium Mycobacterium tuberculosis reduces the beta-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD.",384,0.99999994,-0.052530106,-0.02916246,-0.06620663,-0.025234085,-0.005141821,0.076379195,-0.026446788,0.07402575,-0.03849857,0.023684233,-0.02674572,0.021551361,0.032028094,0.055265043,-0.016245548,-0.0003950926,-0.023790723,-0.0004457628,0.03593633,-0.017471906,0.022301529,0.044540193,0.013413397,-0.08378313,0.058151934,-0.02460568,0.015885273,0.0016579337,-0.0014804053,-0.04696535,0.025333246,-0.050790645,0.06694705,-0.0559669,0.029881088,0.010520074,0.002317931,-0.04344946,0.07496876,0.080818154,0.014812491,-0.019935237,0.024608683,0.049088724,0.091868125,0.06534233,-0.03221678,0.058187265,0.04822038,0.03011564,-0.068236805,-0.058529142,-0.07068481,0.06906563,0.04401334,-0.038050327,-0.03190538,-0.03218196,0.037826236,0.005257033,0.025661027,-0.00735253,0.04265055,0.0131853195,0.034616444,0.033427257,-0.09029286,-0.055716958,0.040780798,0.04046645,0.049908638,-0.028893713,-0.10988457,0.060356356,-0.023783598,0.0047155297,-0.056077044,-0.07480312,-0.036194008,0.07029363,-0.038852442,0.0036352293,0.022034217,0.07127319,-0.0041823313,-0.015166858,0.10570794,-0.017777214,-0.041911274,0.08253178,0.016023425,-0.034829017,0.021461273,-0.04034552,-0.07021352,-0.017610032,0.044900224,0.070533566,-0.057279702,-0.047640342,0.031158838,-0.021743214,-0.07500879,-0.05740371,-0.08626404,0.019420497,0.0060364627,0.06520098,0.04033409,0.008116159,-0.074846044,0.06693184,-0.084043406,-0.047712103,-0.010971303,-0.030668996,0.12608537,-0.025401842,-0.096539535,0.0142359,-0.0445531,-0.013671303,0.05592275,0.029296301,0.000900719,0.053353522,-0.10998427,2.3593496e-33,-0.015272614,-0.030628989,0.008679073,-0.049306124,0.00497269,-0.022572353,-0.10432314,-0.013443113,0.037702683,-0.07387318,-0.07981299,-0.01661881,-0.05655889,0.031965047,-0.061194137,0.05667897,0.019465828,-0.031027595,0.11360168,-0.03856052,-0.033620574,0.041827414,-0.0030364005,-0.0194966,0.032145616,-0.0011035738,-0.0065398817,0.044332404,-0.008060682,0.00046247963,-0.016322408,-0.019703344,-0.09276645,-0.036577296,-0.008155971,0.019787164,-0.056048367,-0.033061273,-0.005363896,0.041797955,0.062297117,-0.011090602,-0.016174894,-0.024474567,0.14956148,-0.02494971,-0.026349198,0.047347024,0.009439315,-0.04601364,0.04586054,0.014429688,0.026708271,0.017884078,-0.016380087,-0.00010678604,-0.008667822,0.07395541,0.018741231,0.045736875,0.07470671,0.014060472,0.027546959,0.11905267,-0.044503357,-0.036700826,-0.0040181684,-0.035097472,0.013785167,0.008700016,-0.010711018,-0.032451287,0.03406722,-0.0062548523,0.10553943,-0.034951586,-0.047020636,-0.01564797,0.0936135,-0.11540088,0.01032934,-0.019017309,-0.053166524,-0.057666387,-0.0039968677,0.004782741,0.019854477,-0.07397556,0.0123786125,-0.029034615,0.04677183,-0.08840315,-0.110180065,0.09437338,-0.0085079,-3.2121933e-33,0.04135495,-0.12754396,0.07263477,-0.078554824,-0.031906765,0.005890344,0.060120456,-0.023464216,-0.01766582,-0.0022919117,0.07732855,-0.08548221,-0.015818855,-0.043736156,-0.0445749,-0.04548213,0.027730417,0.009986609,-0.026094578,-0.016819023,-0.032395795,0.057431802,0.089364424,-0.037762117,-0.049344175,0.04839509,-0.0036955385,0.07182379,0.12502447,0.09499006,-0.014725293,0.06461377,-0.0850973,-0.09134927,-0.08953883,-0.029357456,-0.068840496,0.03239105,0.079680614,-0.055584352,0.041322444,0.05713454,-0.065368645,-0.02353056,0.07676199,0.07053877,-0.0048201727,0.0034546263,-0.0066361004,-0.06475951,0.024064584,-0.04292426,-0.0058966377,-0.009328116,0.056314748,0.0020025193,-0.0006636692,-0.018808957,0.047376018,-0.015550176,-0.035385683,-0.00072641915,0.011212428,-0.012418358,0.060888585,0.09382803,0.073281676,0.13368629,0.0418966,-0.008950049,0.059892416,-0.047497667,0.04553563,0.056255374,0.01518883,0.013279884,-0.03656091,0.017778907,0.030806001,0.009605327,-0.06961211,-0.0043698098,-0.06486475,0.006859742,-0.061331645,-0.060436193,0.029649632,0.08723782,-0.034260638,0.10269595,-0.025943106,0.097700804,-0.06429221,0.029688932,0.053503025,-2.9872865e-08,0.05860048,-0.009704657,0.13054574,-0.0058976184,0.04964336,-0.053880613,-0.075210735,0.026505688,0.108085066,-0.000719597,-0.03858298,0.02969496,0.00973688,-0.03668954,0.025087083,-0.0051869615,-0.013883642,-0.044283036,0.016811447,-0.06831611,-0.0919075,0.029024975,0.0070479093,0.019989735,-0.04791491,-0.025534645,0.03542072,0.021371204,-0.025869455,0.011592231,0.0037408657,0.04090578,-0.01406788,-0.088539235,-0.10099668,0.04215012,0.052341025,-0.025353441,0.09051862,-0.008412317,-0.019268028,-0.09582203,-0.027603876,0.03145068,-0.0020610234,0.007882365,0.025921168,0.04277752,-0.052535895,-0.06830797,0.06122146,-0.035054825,-0.018700408,-0.0528569,-0.06885021,0.046483483,-0.053555988,-0.008905768,-0.05346529,-0.06180811,0.016527671,-0.033129517,0.09314469,-0.01907528 +1.4.1.25,"The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.99.6, D-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine.",384,0.99999994,-0.13574407,-0.04160057,-0.086530246,-0.035431538,0.030599892,0.045587834,-0.060903218,0.028995777,0.00067556096,0.033998225,0.037770163,-0.06403396,-0.086544156,0.02276647,-0.058700763,0.026411816,-0.09689041,-0.029440114,0.016887793,0.0051072016,0.03292714,0.13517225,-0.10329907,-0.011016608,0.048526295,0.036413137,0.09638867,0.049621873,-0.0117144445,-0.037894502,0.035821073,-0.13235882,0.107621536,-0.0231233,0.08192065,0.045087945,-0.0020553388,-0.017822696,0.12268835,0.032734342,0.045160495,0.021967176,-0.029346691,-0.10881912,-0.00090261246,0.031111367,-0.008372268,0.09851094,0.06648586,-0.053843427,-0.015600898,-0.04914672,0.018619752,0.008977367,0.011212173,0.046906788,-0.023675362,-0.023980709,-0.052510716,-0.021948922,0.045087647,0.011551564,0.029975025,0.038065504,-0.0074219396,-0.047869716,0.083092645,-0.046972882,0.100974,-0.046459574,-0.03224071,-0.039018087,0.0016754357,0.05040979,-0.02518641,-0.047755584,-0.022162002,-0.08186602,0.05607724,-0.07610734,0.06308902,-0.046892937,0.034399167,0.034357265,-0.013938176,-0.05354839,0.040084716,0.033762496,0.10262986,-0.033824697,0.0042859325,-0.038158353,-0.041402414,-0.07459101,0.028694486,0.045092728,0.005590491,0.09711682,0.025514197,-0.045949537,0.014987259,0.06515811,-0.02282323,-0.06857221,0.015569969,-0.01007208,0.038425937,0.030753687,-0.021588497,-0.024029924,-0.008305726,-0.020640576,0.0039148573,0.037735216,-0.03302048,0.031761613,0.083396,-0.066174775,-0.08434233,0.033753403,0.0092825545,-0.06366256,0.07739674,0.08583774,0.00745823,0.046177175,-0.085853264,-6.784276e-34,0.0041664285,-0.015485269,-0.03584325,-0.06896904,0.01746854,-0.003801807,-0.099307306,0.04884835,-0.05522338,-0.032871395,-0.07241602,-0.0448213,0.06808568,0.049073752,-0.0014009555,0.03273508,0.008562312,0.014252175,0.053029697,-0.018803874,0.04554372,0.0944996,-0.02757953,0.029220534,0.022395268,0.06922924,0.08634476,0.0005791802,0.026556907,0.00951004,-0.05173512,-0.107793175,-0.07150002,-0.012147602,0.070482984,0.012308645,-0.049564347,0.004867918,0.04750685,0.059456903,0.00015086027,0.014286037,-0.00208379,-0.076492354,0.005999975,-0.028349271,-0.090232074,0.09219141,0.017385762,0.068106115,0.02764474,-0.054349378,0.06652456,-0.07938046,-0.05749381,-0.041964915,-0.05522599,0.031758912,0.109737605,0.060291,0.012232801,0.0636357,-0.040536772,0.07256879,-0.0037371714,-0.049362507,-0.048678864,-0.058511723,0.0033724955,0.04026488,-0.07798793,-0.06795619,0.061887324,-0.04756758,0.02041463,-0.06557955,-0.008226664,0.021518592,0.0050026313,-0.025132341,-0.05818026,0.006494154,0.031000866,-0.0037700036,-0.048610758,-0.025174184,-0.013637394,0.018004885,-0.02640535,-0.006550418,0.00497383,-0.056692977,-0.122947365,0.02553085,0.06822137,-1.7945822e-33,0.02737992,-0.048537705,0.030206064,-0.07650664,-0.07933481,0.1455751,0.049458496,0.056322064,0.044157818,0.007861822,0.06761761,0.020074863,0.03400669,-0.03839216,0.049337856,0.048285175,-0.009366328,0.015671555,-0.02379785,-0.022588952,0.031277373,0.0066050934,-0.010750637,-0.00845625,0.024372209,0.024989529,-0.025928605,0.063852005,-0.0073676757,0.07934692,-0.048245814,-0.007141369,-0.021242933,-0.015986891,-0.059502844,0.09074205,-0.009622345,-0.021260373,0.0064259246,-0.0077789323,-0.0025380196,0.033307903,0.008341719,0.069865935,0.022247916,0.042730525,-0.0043829177,-0.010367708,-0.056504253,-0.11914263,0.033569515,-0.036266882,0.073361546,-0.0064474903,-0.024752768,-0.023454115,0.015672382,0.082903504,-0.12805092,0.01496224,0.013727883,-0.093688615,-0.010386758,0.03636731,0.035775565,0.0016284783,0.007715094,0.021154685,-0.01638459,-0.08285207,0.08716344,0.028833458,-0.0019667312,0.03883706,-0.03509894,-0.017545039,-0.064887315,-0.024206381,0.03143869,0.007873791,0.047521695,-0.028639352,-0.02436716,-0.015807733,-0.055720616,-0.04378399,0.025289867,0.09875422,-0.030437328,0.020638566,-0.040183563,0.014326171,-0.06337731,0.060737837,0.052105527,-3.5174445e-08,0.08117663,-0.025495764,0.07912467,-0.008984248,0.025610546,0.04326602,-0.024864485,0.020623386,0.02620262,-0.007821422,0.012561026,0.025884703,-0.012032999,0.02010559,0.034522843,0.0231619,-0.120661594,-0.00086740154,-0.021048328,0.040397886,0.0010652419,-0.018693203,-0.118541084,-0.02663436,-0.019233638,-0.008939601,0.06256354,-0.02559309,-0.039851952,-0.024698425,-0.03179525,0.01618119,-0.07870864,-0.028637629,-0.09334193,-0.006459127,-0.050638214,-0.01716782,-0.049083948,0.00025470517,0.012406753,0.012939284,-0.087652616,0.014513604,0.02403839,0.044821322,-0.023784898,-0.02851256,-0.008577029,-0.028757889,0.050178435,-0.016096734,0.049774416,-0.04662035,-0.11904116,-0.0044691106,-0.086278215,-0.10885715,-0.018242769,-0.009887418,0.0555761,0.011612186,0.12934738,0.06268359 +1.4.1.26,"The enzyme, characterized from an unknown bacterium in an environmental sample, has some activity with (2R,4R)-2,4-diaminopentanoate. It has very low activity with NADP+ (cf. EC 1.4.1.12, 2,4-diaminopentanoate dehydrogenase). ",384,0.99999994,0.0068108197,-0.012146314,-0.050477106,-0.072631024,0.024408229,0.0044108857,-0.08872216,0.08569227,0.036853604,0.0016973919,-0.029433964,-0.08916609,-0.060597546,0.095624775,-0.03773871,0.04541307,0.0068152803,-0.040135268,0.0070893853,-0.033505604,0.011030911,0.04505465,0.012841822,-0.05666795,0.047909558,0.061491646,0.038616505,0.0042388043,0.004116632,-0.060813382,-0.006500704,-0.0066374405,0.036790535,-0.09336316,0.085542694,0.11484879,-0.027136708,-0.020601075,0.034902655,0.066432886,0.05568336,0.029530123,-0.0636351,0.034910176,-0.047525365,-0.0045421124,0.010228784,0.059897546,0.03291322,-0.031575505,-0.030793224,0.004781069,-0.01230925,0.0064827553,0.015023414,-0.04648168,-0.021727322,-0.019055095,-0.062454883,-0.01972663,0.06494403,-0.056408994,0.033550553,-0.015574335,0.05023082,-0.022936663,0.061105233,-0.08042427,0.025060853,-0.06944566,-0.073924206,-0.009752013,-0.034551907,0.026294112,-0.06640344,-0.05093754,-0.06544584,-0.042954113,0.093343,-0.047069296,0.09968349,-0.043606147,-0.023312198,0.028390216,0.02744441,0.020289488,0.038136348,-0.025994828,0.053483382,0.045788307,-0.020514317,-0.011927145,-0.04130167,-0.016582143,-0.093145005,0.014494685,0.020330302,0.061130486,0.017565267,-0.0072246436,0.039997492,0.087221414,-0.023077102,-0.053241514,-0.0477325,-0.013389982,0.037903808,0.09343978,-0.031172577,0.028800922,0.042296454,-0.02726967,0.05262734,0.021642376,-0.011927759,0.08396177,0.028579207,-0.07609401,-0.12855594,0.01346223,0.025223598,-0.035138294,0.10377591,0.004535681,-0.015846632,0.038605325,-0.108700216,-3.5557751e-34,0.070779905,-0.033202544,0.03490896,-0.050270885,0.0482382,0.009222205,-0.10800325,0.08189121,-0.024587605,0.008596917,-0.0392567,-0.08238738,0.06114796,0.028896281,0.00880193,-0.01201439,0.038107216,-0.026266932,0.029848259,-0.010997344,0.03225571,0.0725013,-0.011555906,0.055513732,0.0498692,0.0393127,0.017728347,0.019676434,0.033484675,-0.0134980315,0.068570025,-0.1613519,-0.10727613,-0.023112163,0.08471496,-0.04724229,-0.038846597,-0.017473392,-0.027778916,0.002916185,-0.08344476,0.07512346,0.027796362,-0.076226175,0.07272005,-0.106664605,0.014154217,0.08980408,-0.014201822,0.055240583,0.021643361,-0.010750151,0.06493276,-0.086827606,-0.029686484,0.032796007,-0.013027564,0.021485254,0.020590676,0.07965339,0.04099643,0.07471461,-0.082356215,0.012186542,-0.0021555321,0.028964208,-0.05601103,-0.08129485,0.022898065,0.09876843,-0.00472691,-0.0007603364,0.046197973,-0.003844192,0.05060611,-0.032803036,-0.0010576643,-0.020992644,0.0457142,-0.030125383,0.0029024207,-0.026204009,0.027185066,-0.0070491238,-0.1044453,0.016543841,-0.03333197,0.012760388,-0.020446656,0.08844286,0.0155804055,-0.040225353,-0.097422205,-0.024537094,0.04744879,-1.7140937e-33,0.053183135,-0.010140262,0.022315469,-0.0682341,-0.01977992,0.11679423,0.024911392,0.005750196,0.010809793,-0.029452823,0.139399,0.08041612,0.045998435,-0.003959123,0.09013922,0.0510004,-0.07435617,0.11096554,-0.045921985,0.03166783,0.011318732,0.08177747,-0.0010432964,0.0131366905,0.032206643,5.8169502e-05,-0.02337666,-0.008594753,-0.0064462046,0.054844152,-0.032919932,0.024047827,-0.0400189,-0.01877347,-0.03248311,0.02097802,-0.038713623,-0.048829768,-0.030441154,0.05262962,-0.033661876,0.056374047,-0.04137492,0.06108096,-0.00150945,0.0004699849,-0.1185587,0.0052125286,0.028993418,-0.055769797,-0.02057122,-0.0058628307,-0.03462783,0.03383273,0.043568857,0.040106475,-0.022398978,0.022485515,0.005029066,-0.0029250593,0.014010306,-0.097274624,0.0029145698,0.033769693,0.045080446,0.015596581,-0.04629524,0.024765257,0.011577773,-0.0518655,0.051255167,-0.040160526,0.017642908,0.017650297,-0.044662423,-0.005056776,-0.08853246,-0.029018248,-0.02494077,0.00025623295,-0.02489109,-0.00071334303,-0.023839114,-0.12094197,-0.024960762,-0.09013432,0.020041866,0.053410906,-0.029514043,0.07295955,-0.008862952,0.04168957,-0.07142393,0.054393455,-0.017936198,-3.887075e-08,0.026840506,-0.052713323,0.115470804,-0.055960365,0.024991253,0.04819475,0.0016365475,0.0017666833,0.048818234,0.029778732,0.030643942,0.085719064,-0.06009309,0.012964978,0.059204657,0.010252896,-0.032081578,-0.016185012,-0.042297285,-0.044407662,-0.01626012,-0.009041935,-0.10484636,0.024289738,0.018780775,-0.062626734,-0.022323804,0.013515533,0.018226253,-0.05846037,0.027173422,0.070153594,0.054803003,-0.07422664,-0.13020346,0.030695342,-0.06366046,0.036808282,-0.109876946,0.07627502,0.004939927,-0.08601758,-0.07607758,0.016640436,0.004125349,0.049656622,0.036740903,-0.045185287,-0.069487706,-0.04485435,0.06577797,-0.010568263,0.010524735,0.01890812,-0.07416212,0.076969944,-0.04939825,-0.08202754,-0.073335655,-0.059110872,0.036256224,0.010414742,0.07029926,-0.033633485 +1.4.3.25,Contains FAD. The enzyme from cyanobacteria can also act on other basic amino acids with lower activity. The enzyme from the bacterium Pseudomonas sp. TPU 7192 is highly specific.,384,0.99999994,-0.07804565,-0.09269822,0.0005167262,-0.045901865,0.0824873,0.07277131,-0.052788958,0.07181189,-0.025687762,0.04223734,-0.00013213238,-0.075294584,-0.079004094,0.099227875,-0.01007119,0.063718304,-0.03063678,-0.005090715,0.017509585,0.028572867,0.026975289,0.08564634,-0.031496268,0.039913416,0.012092947,0.047260795,0.016393257,-0.0012236917,-0.0017803091,0.018185612,-0.0618366,-0.04543216,0.0952172,-0.02220116,0.065416045,0.03397947,-0.02318244,-0.05015576,0.06561267,-0.0014046485,0.04512486,0.0052073007,0.04199557,-0.03060766,0.02585509,0.03365664,0.05596012,-0.023542792,-0.0032186292,-0.026472433,-0.059596945,-0.041878,-0.008775944,0.04504038,-0.037927307,0.061647844,-0.030222408,-0.07065683,0.0024319333,0.004605466,0.0005931029,-0.029039752,0.006897202,0.011129251,0.05629343,-0.022516696,-0.076953575,-0.021738347,0.016540408,-0.06959844,0.005494437,-0.07709452,0.027296366,0.043220617,0.01657488,-0.010945772,0.023267223,-0.06028871,-0.0126324175,-0.082810044,0.032067973,-0.02481512,0.054475553,0.080539376,0.03774805,-0.031056093,0.017993063,0.010447564,-0.038717914,0.04505693,0.090860955,0.025888674,0.013929895,-0.1116573,-0.03292934,0.063620456,0.011997007,-0.009898633,0.015906043,-0.008025351,-0.0125644645,0.05751439,-0.012902099,-0.100367084,-0.045378525,0.0089903,-0.0028845696,0.06686628,0.013884754,0.013793015,-0.037858065,-0.0010311062,-0.0222531,-0.049014237,-0.026201567,-0.013655109,0.07612976,-0.074283704,-0.064511575,0.0014729413,-0.038616575,-0.104988895,0.08462624,0.12629943,0.036059856,0.02350927,-0.14456475,2.030673e-33,0.089120366,-0.06511135,0.007068156,-0.109253876,0.029826434,-0.002200753,-0.04225501,0.008741228,0.06189851,-0.048834953,-0.08169051,-0.011891569,0.024342261,-0.010467056,-0.067356035,0.056760654,-0.05758807,-0.062244542,0.05958929,-0.036281247,0.050298214,0.08594812,-0.018308816,0.0046917745,0.045664664,-0.013871284,-0.048437115,0.015863651,-0.00850763,-0.013954345,-0.026048744,-0.092277765,-0.11488433,0.0055618584,0.09232075,0.03385142,-0.043166727,-0.054112274,-0.041391607,0.062861495,0.00088257826,0.024927642,-0.003714233,-0.0028779595,0.059391174,-0.018653138,-0.056715664,0.068008915,0.017407136,0.045174185,0.10445946,-0.0681466,-0.0006407906,-0.012976633,-0.04615993,-0.012762063,-0.028577715,0.030293163,0.06351594,0.045359455,0.020325549,0.0021286064,-0.045990944,0.059392605,-0.0122164115,-0.0025799992,-0.035934407,-0.026183084,0.009557387,0.08876892,-0.054082666,-0.027012324,0.07756243,0.018664192,0.07194776,-0.08538686,-0.016600573,-0.03140208,0.016628008,0.04125448,-0.0057239844,-0.1181731,0.03501331,-0.023000278,-0.07222652,0.022098543,0.015898082,-0.075681664,0.016199965,-0.025331182,0.0551477,-0.09586202,-0.09204804,0.08274765,0.008871892,-3.468717e-33,0.07637344,-0.10331703,0.076742,-0.017592296,-0.050693322,0.052000593,-0.013380935,-0.029478986,0.042717457,-0.031038718,0.08990096,-0.06331059,0.035081763,-0.0018308319,0.026900496,0.04643261,-0.034844056,0.08550845,-0.021000935,0.001435971,-0.05577582,0.033354886,0.02380344,0.023739597,0.07370952,0.01710339,-0.095736034,0.1110987,0.050857194,0.055308733,-0.04257749,0.08297537,-0.05436409,-0.05919495,-0.05879857,-0.012858552,-0.057081006,-0.027782127,0.028888403,-0.026260728,0.0947008,0.0025792466,0.008738711,0.08942431,-0.038415726,0.03420356,-0.035086766,-0.016196264,-0.023485249,-0.050949074,0.06263167,-0.048315022,0.012607674,-0.0055546737,0.070480004,0.07580173,0.02453044,0.024414202,-0.035132874,0.009392952,0.014370097,-0.109194145,-0.021963814,-0.034554027,0.097102046,0.03829762,-0.009790905,0.10222938,-0.0042682416,0.019452114,0.048923492,0.026934162,0.038891308,0.037583396,-0.05650016,0.019514995,-0.0070811072,-0.040111993,0.025777122,0.023827637,0.056315973,0.029534148,-0.041599836,0.00077946845,-0.06467912,0.068434305,0.03070215,0.07076213,-0.048900455,0.03458031,-0.055931885,0.052983783,0.08053303,0.041013733,0.036407795,-3.2937884e-08,0.053407896,-0.026938062,0.07207628,-0.03068304,0.04137301,0.072252415,-0.022969445,0.010392109,-0.015204595,-0.018897003,-0.02620997,0.050494153,-0.034808766,-0.037174836,0.06684142,-0.011568373,-0.090532236,-0.020828454,-0.03834543,0.012968497,-0.08604642,0.008318271,-0.08468747,0.024414817,-0.06634649,-0.03358772,0.04796901,0.054116342,-0.005267997,-0.042692047,-0.020579893,-0.07413775,-0.017904313,-0.024934508,-0.08065452,0.05113805,0.03289,-0.13711104,-0.10900303,-0.004634019,-0.018427819,-0.04038328,-0.068366915,-0.008878058,-0.03295122,-0.031178592,-0.006327641,-0.004756929,-0.03819041,-0.022085544,0.05580125,-0.032100555,-0.0029634594,-0.02387911,-0.09244272,0.009798877,0.01594116,-0.063442476,-0.07745445,-0.01652221,0.022614455,0.0121851005,0.14008053,0.0553193 +1.5.1.51,"The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.",384,0.99999994,-0.076858595,-0.04406818,-0.14846584,-0.014551054,0.027515193,0.04062114,-0.097033896,0.030771103,0.051325977,-0.027261762,0.04257783,-0.07240141,-0.081525,0.026229255,-0.03632533,0.022717847,-0.123899385,-0.025334897,0.012128984,-0.012469962,-0.025904307,0.09200902,-0.03561827,0.012998368,0.017426891,0.009585468,0.027764978,0.004030493,-0.023336772,-0.013342912,0.00935103,-0.033000454,-0.00049629365,-0.021644417,0.020038405,0.096443206,-0.028538337,-0.0646592,0.05061092,-0.015093308,-0.02517881,-0.027321825,-0.020110697,-0.033950593,-0.050058883,0.021418782,0.03336973,0.04543837,0.041345023,0.011274749,0.029269084,0.014109281,-0.0737183,-0.017357478,0.004116152,0.022384306,-0.06316322,-0.029206026,-0.003708391,0.01743206,0.0313133,-0.018445175,0.034029048,0.015374857,0.01286004,-0.07061834,0.02400499,-0.07671951,0.033206042,0.020971801,-0.06860277,-0.073094405,0.0061674085,-0.008048583,-0.017376628,0.060155824,0.012741505,0.00092549395,0.016682204,-0.044477027,0.039665252,-0.0026141661,-0.020089101,0.16675237,0.024408735,0.029893033,0.0382494,0.0023068932,0.019066252,0.060685944,0.037413552,-0.03623728,0.0048862784,-0.09420976,-0.060701102,-0.0033649877,-0.0655983,-0.0021130492,0.0027137874,-0.036633283,-0.065798916,0.03432491,0.021790186,-0.06302185,0.024653813,-0.05974364,-0.0117956,0.06342745,0.06668284,-0.028035758,0.048746657,0.0832927,-0.037558455,-0.0030144893,0.035323013,0.08056044,0.058737285,-0.08686994,-0.081454426,-0.024333376,-0.019558199,-0.056196537,-0.014022286,0.04394561,-0.07590965,-0.027252872,-0.087153666,4.038819e-34,-0.0058992165,0.007944087,0.053617954,-0.0658718,0.023992356,-0.040204953,-0.070829846,0.026895802,-0.012394158,-0.05377615,-0.05258952,-0.054394007,0.04937922,-0.0033554737,0.052790433,-0.08612988,0.0006518191,0.015646616,0.035684213,-0.06948116,0.01733254,0.064531095,-0.03326312,-0.012932494,0.007572779,0.032155268,-0.0055375723,0.06058365,0.09119642,-0.025587877,0.026729802,-0.06451023,-0.042697277,-0.037678234,0.12205065,0.016896699,-0.01412116,-0.015559364,0.037711613,0.015209923,0.013815262,0.0076284683,0.008706029,0.031657323,0.051821474,-0.0354806,-0.047098596,0.06859273,0.039582543,0.006132508,0.014183654,-0.03980384,0.11507117,-0.0334203,0.007191199,0.042979013,-0.00059007946,0.023707718,-0.012834786,0.10224806,0.021196045,0.033763416,-0.05525326,0.022304444,-0.009475469,0.040824816,0.07674415,-0.058797732,-0.0017991284,-0.015602839,-0.026583662,-0.008796233,0.050007157,-0.00036239615,-0.011884101,0.03226959,-0.024144826,0.020118061,0.052175626,-0.047135428,-0.052770212,0.0317244,-0.0016737916,-0.07634136,-0.091070555,-0.016276045,-0.035408728,-0.05942932,-0.0068584434,0.024737565,0.035810646,-0.09613067,-0.037931483,0.024952918,-0.05150428,-3.227319e-33,0.0012124055,-0.18474562,0.03433104,-0.11103902,-0.05421206,0.12954497,0.062565126,-0.027241407,-0.063821144,0.025565384,0.057863515,0.030109523,-0.031039543,-0.024526555,-0.024584172,0.017059535,0.009800716,0.07721343,0.03228794,0.028076237,-0.003665327,0.10433976,0.12297409,0.0076074116,0.039712053,0.058425535,0.045212753,0.070177294,0.015384574,-0.0033536213,-0.023187065,-0.05792448,-0.042273596,-0.031110967,-0.04825804,0.044380993,-0.0027346015,-0.0026383882,0.05505918,-0.05454211,0.038781717,-0.006076253,-0.022843082,0.07838672,0.038674865,0.054814313,-0.118215196,0.08823282,-0.042205207,-0.0806491,0.01282471,0.08393772,0.04574218,0.030349405,-0.01725726,0.04069953,0.04402962,-0.05396299,0.0037748262,0.0068661207,-0.049610473,-0.071181595,0.027081048,0.045753676,0.035026155,0.046007905,0.021345584,-0.014654699,0.022490878,-0.10029354,0.08592895,-0.009793421,-0.002739179,0.0369116,-0.048910853,-0.037183,-0.021056972,-0.10964092,0.007770762,-0.02327992,-0.029289503,0.00676491,-0.004947479,-0.007122607,-0.019017749,-0.08657701,0.08235033,0.07123968,0.006167807,0.008136531,0.031858962,0.04046319,-0.037374645,0.07098218,0.0873077,-2.8048182e-08,0.058953945,-0.04791834,0.14179254,-0.085477315,0.015642172,0.017978467,-0.029385917,-0.04763751,0.017372953,0.006643316,-0.08653439,0.0056053638,-0.041333128,-0.03152253,-0.022689806,0.028982572,-0.061096862,-0.016864512,0.012094666,-0.062710434,-0.050545376,-0.0011370349,-0.0584852,-0.02839119,0.047991384,-0.0420328,-0.022863852,0.06985307,-0.040228948,0.008368273,0.018733397,-0.0067238193,-0.037168622,0.015260413,-0.04551714,0.035033934,-0.033418316,-0.06876233,-0.04950895,0.100534305,-0.00751521,0.0392879,-0.051250983,0.035239775,-0.011207407,0.06269071,0.010902515,0.049958598,0.0022532,0.045323998,0.049961373,-0.045786783,0.024915962,-0.05512719,-0.16992119,-0.006121778,-0.026921572,-0.110574156,-0.03447149,0.091124706,0.035515208,0.090245716,0.13388273,0.071804956 +1.8.2.5,"The enzyme is found in sulfate-reducing bacteria. The source of the electrons is molecular hydrogen, via EC 1.12.2.1, cytochrome-c3 hydrogenase. The organisms utilize the sulfite that is produced for energy generation by EC 1.8.1.22, dissimilatory sulfite reductase system.",384,1.0,-0.07330677,0.028616568,-0.090136744,0.007283887,0.019709885,0.050504178,-0.0067501934,0.0111615285,0.033542227,-0.0013881035,0.00142995,-0.057872504,-0.013030317,-0.008857616,-0.06983989,0.0054169074,-0.029491369,-0.007164218,0.041161112,-0.056060422,0.05614994,-0.019422565,-0.011913035,-0.04280881,0.043943033,0.06721981,0.046296168,-0.042574506,-0.06628353,-0.03828772,0.018326098,-0.040376317,0.057475787,-0.059090342,0.02984741,0.12445478,-0.054294515,-0.08876504,0.06150011,0.03133889,-0.0020773185,0.04960004,0.01649319,-0.06250085,-0.04138247,-0.02299639,0.07104179,0.021066675,0.048041794,-0.12346297,-0.013020079,-0.017446144,-0.0067353123,0.03710416,0.0057129287,0.014331724,-0.016977604,0.001417768,-0.018844178,-0.056137085,0.023791282,0.014249447,0.013647731,-0.016282208,-0.016064601,-0.04765754,0.06640436,-0.048859112,-0.0016448568,-0.10368438,-0.10866181,-0.054225728,-0.0128949005,0.0024983508,-0.021149855,0.028966244,0.071350105,-0.052258097,0.10032514,-0.0236229,0.0028894066,-0.024950594,0.0036123227,0.10276788,0.0232236,0.023173375,0.066605024,-0.034044158,-0.012026214,-0.019383732,-0.010679902,-0.05160386,-0.008889047,-0.028806373,-0.039322976,0.06067197,0.025728261,0.13725375,0.07819732,-0.030886412,0.04902329,0.09430077,-0.040695723,-0.06990403,-0.048368372,-0.008903182,0.014198461,0.18476874,0.0543989,0.035719275,-0.013256162,-0.012016249,-0.010405243,-0.020316234,-0.0036284525,0.087187916,0.07330546,-0.04652397,-0.08473532,0.053757083,-0.00053740595,-0.024559626,0.011595954,0.036279786,0.022423685,0.012236087,-0.14273198,2.274199e-35,0.0865789,0.037614353,0.08980297,-0.10244604,-0.05595995,0.040290963,-0.079613686,0.06598012,-0.0011656734,-0.07055573,-0.058215834,-0.029117744,0.056384955,-0.012176977,-0.07277068,-0.028267913,-0.042542815,-0.018255329,0.023816895,0.0126520395,-0.025616016,-0.015917486,-0.0019498353,-0.021905597,0.03191333,0.02018787,0.013177208,0.005038269,-0.01036215,-0.0077740448,0.041597378,-0.0792077,-0.04057312,0.027253365,0.07245877,-0.022731256,-0.034043018,0.033629145,-0.007349708,0.00078506843,0.034564923,0.057765815,0.068891644,-0.044479158,0.046758108,-0.010553843,-0.06966547,0.017590795,0.06995566,0.05553764,0.039013505,-0.042514805,0.09912561,-0.042541817,-0.02719456,0.038051527,-0.0062776604,1.2642034e-05,0.03576604,0.055025745,-0.00076839677,0.11615977,-0.055198878,0.01838437,0.032095015,0.055439185,-0.009708932,-0.02549317,-0.020398997,0.075718954,-0.11913246,-0.029214352,0.033806223,-0.0055070133,0.00974481,0.012457418,-0.09059804,-0.031584423,0.03511668,-0.018447906,-0.017010067,-0.085530855,0.020065758,-0.030966742,-0.0523015,-0.06403678,-0.04042085,-0.021406507,0.012606499,0.04389454,0.021628976,-0.10607399,-0.072669394,-0.02084902,-0.02168463,-2.3396557e-33,0.056179695,-0.017064802,-0.02503469,-0.13619055,-0.0053085135,0.03844859,0.037916448,-0.011042464,0.03971352,0.05520119,0.060694326,0.013965394,0.056971986,-0.04343826,0.021957744,0.019386869,-0.0064192475,0.013460692,0.025514014,0.019420214,0.0021194445,0.08078384,0.070741676,-0.03267665,0.05841284,-0.017814053,0.010280879,0.01928384,0.08248432,-0.03639283,-0.057627354,0.0032088454,-0.011966488,-0.06709486,-0.053076036,0.011606238,-0.06368875,0.030344954,0.03898532,-0.015666543,0.026230227,-0.038947493,0.007059214,0.11574032,0.060161747,0.08107577,-0.079181015,0.06624306,-0.0005291021,0.020104665,0.013229158,-0.032966204,0.02963638,-0.0063861343,0.011692764,0.024856376,-0.004776623,0.070139,0.00081317977,-0.010879297,-0.09161619,-0.06509057,0.036802117,0.014482041,-0.03153499,0.022264486,-0.039080206,0.020563044,0.029543571,-0.05596095,0.020682942,0.01452758,0.0028818056,-0.018005993,-0.1098919,-0.018707342,-0.091170244,-0.0033902847,0.028999463,0.011117318,0.042004038,0.068920955,-0.034689445,-0.094358474,0.06981461,-0.08562283,-0.012351968,0.040956885,-0.013172149,0.006681684,-0.057820097,0.028213145,-0.034456972,0.020086218,-0.028179675,-3.705327e-08,0.0020353415,-0.016848834,0.10135332,0.0076480615,0.070985444,0.04833448,0.034395635,0.02456466,0.062342506,0.014709498,0.011101935,0.09798138,0.014602325,-0.050975483,0.064781554,0.03316863,-0.043189175,-0.02902568,-0.019345088,-0.020674894,0.018695103,-0.08432629,-0.14108312,0.113358304,0.09311796,-0.08779316,0.07878299,-0.048659932,-0.09891921,-0.025490219,0.008436429,0.0366667,0.038118094,-0.015728237,-0.057732802,-0.021676587,-0.04786068,-0.048170816,-0.027892062,-0.0030093195,-0.018389653,0.016488224,-0.067224115,-0.023895636,-0.0016841727,0.070321105,0.00060987123,0.049960196,-0.013505488,0.008874689,-0.00081626564,-0.07569344,-0.0127666015,-0.12417484,-0.10026533,0.069973074,0.009328016,-0.08497102,0.016358577,0.0074251,0.041191027,-0.0010378555,0.13386852,0.030236721 +1.8.5.7,"This type of enzymes, which are found in bacteria, halobacteria, fungi, and plants, catalyse the glutathione-dependent reduction of glutathionyl-hydroquinones. The enzyme from the bacterium Sphingobium chlorophenolicum can act on halogenated substrates such as 2,6-dichloro-3-(glutathione-S-yl)-hydroquinone and 2,3,5-trichloro-6-(glutathione-S-yl)-hydroquinone. Substrates for these enzymes are often formed spontaneously by interaction of benzoquinones with glutathione.",384,0.99999994,-0.054824233,-0.015330983,-0.059584096,-0.019398894,0.06328825,0.08549688,-0.05049768,0.05827801,-0.0014491738,-0.055508524,0.03742692,-0.028481442,-0.0017399323,0.02496338,-0.08484099,0.09255436,-0.078292854,-0.00897537,-0.070101246,-0.03400147,-0.013253153,-0.02475489,-0.10365847,0.04303398,0.03593458,0.019490607,0.0449386,-0.04923167,-0.0735683,0.018436443,0.027524121,-0.0398876,0.039622623,-0.06088649,0.030708635,0.09040658,-0.026031772,-0.061436675,0.10079613,0.0271019,0.0031416574,-0.0028052712,-0.05321908,-0.041990615,0.050109047,0.0501615,0.016219666,0.05209378,0.037883256,-0.03447863,-0.026039615,-0.02171913,-0.054216024,0.0771053,0.00033872313,0.0010853128,-0.020585027,-0.01769343,-0.049308196,0.05468845,0.00965245,0.0063301264,0.02684945,-0.021628123,-0.023228439,0.012529408,-0.05002155,-0.060951464,-0.00653883,-0.04689452,-0.048827887,-0.065473095,-0.0041948897,-0.010520071,-0.03492037,0.058846667,-0.062470254,-0.042763475,0.048405975,-0.08408203,0.007027236,-0.05027523,0.054659523,0.09823671,0.009705319,-0.03677025,-0.0016285018,-0.012736678,0.08059595,0.03280581,-0.0020033445,0.010344148,-0.04447842,-0.036735293,-0.13202718,0.06299931,-0.0299443,0.004537109,0.046819758,-0.028184174,0.009629083,-0.017903715,-0.021969078,-0.114289925,-0.090883985,0.026481139,-0.001489283,0.06473761,0.029625425,-0.04251951,-0.03983035,0.042437594,-0.0073043043,-0.031400047,-0.03689111,0.0822172,0.11960285,-0.038961753,-0.15792257,0.037410922,0.023695676,0.007935022,0.08953202,-0.013324452,-0.05762125,0.062033676,-0.04154639,2.790562e-33,0.09768144,0.019348023,0.07328614,-0.039163947,-0.0014777574,0.005982674,-0.08189881,0.013231579,-0.040493075,-0.10489973,-0.033794265,0.020647451,-0.035648618,-0.044355217,0.029344847,0.08294896,-0.007979399,-0.01477663,0.010989373,0.018365925,0.0105227325,-0.022572048,-0.048620056,-0.028312389,0.044641424,0.10761897,-0.025067255,-0.018094037,-0.0256247,0.014540289,-0.02486205,-0.040347777,-0.06801989,0.012385939,0.047251128,0.01963583,-0.07870234,-0.021829795,-0.017580932,0.019023111,0.0024593938,0.0023914902,-0.01672101,-0.031372204,0.025182564,0.0041434346,-0.042031758,0.059307944,0.04913087,0.067657225,-0.018033369,-0.039515674,0.07008477,0.040886514,-0.011746745,-0.0018632204,0.01617359,-0.057737373,0.043611404,0.025783349,0.0056916033,0.1337781,-0.04240692,0.01809621,0.00036170482,-0.055292767,-0.05185247,0.06528025,-0.06950922,0.051357288,-0.03868878,0.013490758,-0.035907466,0.07548715,-0.0023596229,-0.08238267,-0.03883121,-0.06475865,-0.025155155,-0.0010530893,0.0012828541,-0.029016377,0.06769771,-0.061125517,-0.06940715,0.042122383,-0.0060413317,0.0016440402,-0.053515375,-0.00764367,0.074446395,0.0073476206,-0.008583254,-0.024549467,-0.03866621,-4.238932e-33,0.06186215,-0.12987217,-0.022013819,-0.06309668,0.005366624,0.03733177,-0.018826341,-0.049596276,0.04746519,0.03717131,0.02085952,0.005654608,-0.026457617,-0.01215336,0.00081946165,-0.07413105,0.025565753,0.10203116,0.006464941,-0.06538793,0.058096495,0.0395997,0.010576879,0.015117589,0.010723921,0.008570519,-0.04205438,0.028541705,0.08905756,0.1128413,-0.058546964,0.0599932,-0.0014346957,-0.052847996,0.08613253,0.0130806435,-0.052831206,0.049345415,0.04749852,0.001014275,-0.0041443044,-0.021966524,-0.012952312,0.042990644,0.047151003,0.12105451,-0.1283148,0.032748967,-0.027575018,-0.016407862,0.061616797,-0.03676967,-0.009010795,-0.013585422,0.032912627,-0.01285952,-0.028861491,-0.048486628,-0.04061893,-0.028245747,-0.04743342,-0.07795195,-0.03438937,0.0037098494,-0.006748156,0.110076964,0.07620247,0.06816425,-0.0015673732,-0.02060285,0.048068818,-0.009786098,0.034180533,0.07718328,-0.09221788,0.008981409,-0.060384203,0.0020025657,0.04163172,0.0072438153,0.052278142,0.01345122,0.05011136,-0.037600037,-0.041701224,-0.08745692,-0.062962554,0.082667604,-0.022415774,0.037538566,-0.07021396,0.078747466,0.005374129,0.0154597685,0.016728666,-3.9076006e-08,0.03463592,-0.08061259,0.04806905,-0.034193493,0.008952507,0.008236488,-0.011643558,0.026204372,0.13998696,-0.051222432,0.00594305,0.05581514,0.060855944,-0.0063911,0.019944608,0.03191052,0.078918554,-0.009950139,0.00038399565,0.03622851,-0.07297973,0.013438312,-0.08230571,-0.022905944,0.016793933,-0.08062956,0.05584139,0.04261218,-0.00032028454,-0.021070639,0.0051409495,-0.008791319,-0.0019154655,0.007374148,-0.061133593,0.0464736,-0.07029929,-0.019459154,-0.0011370106,-0.026078401,-0.018982893,0.049995232,-0.08646813,0.023592904,0.07094258,0.0022523773,0.029540954,0.00045379438,0.015832514,0.02969403,0.0027433182,0.00013343926,0.06639788,-0.043787073,-0.13339336,0.08804465,0.082959875,-0.08513877,-0.06643054,-0.12156699,-0.016548343,0.008938939,0.14143863,0.11430829 +1.14.11.55,"Requires Fe2+ and ascorbate. The enzyme, found in bacteria, is specific for ectoine.",384,1.0,-0.0021985075,-0.048464976,-0.09495629,0.06614376,0.07106851,0.008012616,-0.02327956,0.04295327,-0.014890273,-0.039175596,-0.0021153484,-0.095251344,-0.07361351,0.05872722,-0.014607611,-0.027008912,0.028464416,-0.021159217,0.013424282,-0.015148686,0.090472415,0.04624246,0.050000343,-0.035066713,-0.08318774,0.00021129749,0.036173042,-0.035383873,-0.023132373,-0.11231924,-0.0042050635,-0.045021616,0.0862056,-0.055421025,0.009406083,0.09157135,-0.047691476,-0.08574979,0.019030266,0.023682082,-0.00072084356,-0.009980969,-0.0073320395,-0.014604136,0.0097614685,-0.08119079,0.080967344,-0.035046954,0.05996182,0.014862387,-0.0313944,-0.03197294,-0.031859517,0.035442118,-0.029649453,0.04013853,-0.08422616,-0.044722375,-0.065283686,0.008380036,-0.012885501,0.028046392,0.026570745,0.0049860873,0.017175177,-0.044151563,0.02061727,-0.05926166,-0.011729279,0.020427125,-0.04408402,-0.10149351,0.031856764,0.1031852,-0.00251897,0.029003838,0.054448515,-0.047951847,0.047411434,-0.007621448,-0.05761026,-0.05734452,-0.01796271,0.051229082,0.05097221,0.0629885,0.021027034,-0.031431124,-0.06002233,0.10980243,0.057911742,-0.010142163,-0.01597833,-0.025300348,0.029450625,-0.03493853,0.042123385,0.06211872,0.0059724087,-0.053809416,-0.064560615,0.091587186,-0.05525807,0.042041678,0.0044655795,-0.0631213,-0.006544113,0.055739563,0.04965154,-0.02545781,0.004089186,-0.030278936,0.026031243,-0.015941141,0.036089856,0.08710573,0.032188173,-0.08391271,-0.022710903,0.05090679,0.035782535,-0.024135072,0.014698572,0.08940579,-0.053143024,0.019566458,-0.06990518,-1.474718e-33,0.077810034,0.051369272,0.04564358,-0.028096668,-0.0796206,0.086559154,-0.09092297,0.012230841,0.03381564,-0.07805617,-0.074429855,-0.0669362,0.118711255,0.023275562,-0.011498003,-0.05888246,-0.049788706,-0.07457101,0.086770065,-0.023012696,0.041720584,-0.011572992,-0.034720648,0.024179488,-0.056487672,0.036822688,-0.021148168,0.031244505,0.051683806,0.007456376,-0.0012403266,-0.08309564,-0.06401039,0.030937124,0.05272733,0.058895584,0.0063932473,0.0032240944,-0.04094395,0.009202024,0.002622244,0.058832597,-0.017960008,-0.017973764,0.07001439,-0.09004957,-0.05705344,0.1268905,0.07153447,0.06980578,0.028992034,-0.011167388,0.13605319,-0.012499472,-0.014944182,0.07110787,-0.05563478,0.0032110484,0.007430039,0.062090185,0.018108653,0.05625576,-0.0047370153,0.07460064,-0.007206789,0.08182837,-0.04568813,0.00051600207,-0.0048203636,0.032260373,-0.09615473,0.013966787,0.05744249,0.021435855,0.01429499,-0.008157611,-0.13162212,0.024146965,0.041688297,-0.011958679,0.040702518,-0.06869861,0.02845814,0.015824523,-0.017473677,-0.012744597,-0.01547394,0.042233013,0.039665654,0.048893124,0.058127053,-0.06545137,-0.06704818,-0.017938884,0.046836574,-6.2150953e-34,0.066185996,-0.08084387,0.020652292,0.007689007,-0.006898758,0.059507895,0.0333171,-0.10663935,0.020311963,-0.011068579,0.035839416,-0.03659163,0.045253545,-0.11359523,0.013424015,0.0033674403,-0.1412007,0.041038293,0.06597822,0.032937143,-0.04312466,0.0486193,-0.011402728,0.036567263,0.071389414,0.033305455,-0.08408394,0.00093343895,0.018919833,0.0065636868,-0.0001993491,0.03781456,-0.07561,-0.11192062,-0.061150476,-0.005792304,-0.05628945,0.0024523577,0.027842563,-0.041319296,-0.02540366,0.047161404,-0.006210133,0.12065981,0.022223216,0.096335776,-0.015812349,0.044129513,0.016132519,0.0142943645,-0.023241417,-0.066414,-0.07325621,-0.035627566,0.016623871,0.025234114,0.031020373,0.020235145,0.0012603436,0.04171064,0.021990655,-0.05305782,0.035032604,-0.032098774,0.023066549,-0.06828342,-0.010552704,0.11927576,0.041495595,0.02361159,0.061992403,0.021057319,0.049328063,-0.026522312,-0.034725796,0.014500529,-0.06336906,-0.034539036,0.009570912,-0.018398626,-0.030604137,0.06738973,0.0002480556,-0.035758052,-0.0035690567,-0.06207422,0.015576147,0.0020189218,-0.06385604,0.022663707,-0.07962174,-0.08240045,0.0069580073,0.039243445,0.042212874,-2.4578931e-08,0.0052078124,-0.013246478,0.060453363,-0.040047824,0.055288453,0.04410393,0.018431181,-0.043624174,0.033230882,-0.06321703,-0.03636516,0.089365624,0.051777516,0.039550103,0.049967863,-0.018472223,0.00955696,0.025554743,-0.01520354,0.0104911355,-0.124419875,-0.058701348,-0.12177849,0.035857935,0.06940975,-0.04388082,0.035955694,0.04753735,0.013720665,-0.04167974,-0.017737975,-0.036087684,0.021456992,-0.03979027,-0.10412541,0.008229967,-0.034720402,-0.056466866,-0.05452189,-0.01372716,0.0048199226,-0.02498703,-0.021370074,-0.007862806,0.02841705,-0.007908214,0.01100829,0.0019649835,-0.044913225,-0.0068009724,0.02050715,-0.091573864,0.0090571,-0.033600666,-0.010815458,0.06803832,0.02221415,-0.095020674,0.06543287,-0.04675875,-0.024709886,0.0100609455,0.17610812,-0.040383346 +1.14.11.56,"Requires Fe2+ and ascorbate. The enzyme, isolated from Rhizobium species, only produces cis-4-hydroxy-L-proline (cf. EC 1.14.11.57, L-proline trans-4-hydroxylase).",384,1.0,-0.0081432825,-0.09528348,-0.15391351,0.046117593,0.079026565,0.036041316,-0.051039726,0.0440077,-0.040481113,-0.049708463,0.02926692,-0.031082297,-0.024846537,0.044382617,-0.04686701,0.011789502,-0.017019363,-0.04894732,-0.02045121,-0.016480232,0.06186317,0.018627197,0.036799137,0.0067757443,-0.00041393258,-0.03970678,0.06892881,-0.013903104,-0.01549902,-0.096900254,0.001859043,-0.06705893,0.04672883,-0.08063747,0.078743264,0.042027995,-0.042814836,0.002228334,0.026919585,0.023233453,0.012341355,-0.054359358,0.043450497,-0.009635239,-0.026416276,-0.07842529,0.0030476558,-0.025538169,0.07759879,-0.014247031,-0.087547325,0.010680484,-0.06496028,0.09642358,-0.06643972,0.023777552,-0.020805093,-0.052605588,-0.091078974,0.029756898,-0.024319243,-0.0065745646,-0.025574986,-0.04519289,-0.0293515,0.020711308,-0.05631419,-0.01627895,0.04940894,-0.005390174,-0.050791267,-0.051737066,0.0047731376,0.03145505,-0.0032395662,0.0059382925,0.03465141,-0.01789793,0.05268705,-0.015588137,-0.025138106,-0.014542872,0.013439021,0.014263167,0.018212484,0.060305584,0.0041990536,0.0293351,0.03133863,0.04189671,0.051302392,0.07635943,0.0010781517,-0.013941611,-0.07005806,0.0023354979,0.03468329,0.008790473,0.012068335,-0.03904447,0.030409517,0.0042118076,-0.00046406707,-0.09707638,-0.10342064,0.043731183,-0.019318027,0.10649906,0.015845025,-0.008991844,0.021405531,-0.012989782,-0.0009158298,-0.024920408,0.03644073,0.05300166,0.035050098,-0.057857748,-0.041103356,-0.0189038,0.02033018,0.021025905,0.06246359,0.0159104,-0.028506748,0.08167976,-0.08522934,-6.5318924e-34,0.057495475,0.07631058,-0.029985959,-0.033219974,-0.04601199,0.083277956,-0.12822422,-0.008352348,-0.086513154,-0.10162031,-0.055986054,-0.07788848,0.0063244556,-0.061763898,-0.015042306,-0.036402144,0.017299403,-0.037914336,0.059705626,0.079969175,0.009059156,0.05371944,-0.03304982,0.036732197,-0.03101127,0.035373412,0.06525795,0.021205297,-0.013186561,0.017365169,-0.0054485984,-0.06544601,-0.077757984,0.003589418,0.09951354,0.0375985,-0.02416023,-0.028919682,-0.013906213,0.014893144,0.0052471715,0.07839567,-0.0027241658,-0.039965063,0.1326449,-0.09292011,-0.043806538,0.1687696,0.025081675,0.0856266,-0.0066547254,0.03780076,0.10424612,0.022101915,-0.06794953,-0.013379324,-0.049732342,0.06517933,0.102821715,0.026035663,0.0002671944,0.07625078,-0.049363617,0.064870164,0.018430395,0.018245159,-0.024857815,-0.00017491514,-0.033007853,0.073290855,-0.05752206,-0.021926684,0.058896076,-0.0063950396,0.056736305,-0.07504779,-0.11174584,-0.021716706,0.08029218,0.0369526,-0.024556812,0.030545406,-0.00069988496,0.017202137,-0.019589463,0.0009738851,-0.0007952172,0.05930416,-0.008068346,0.009182263,0.11155492,-0.069651134,-0.019935748,0.01866066,0.03551189,-5.171696e-34,0.10290909,-0.060132876,0.042671688,-0.040066246,-0.019838663,0.019280218,0.08412533,-0.08619791,0.03330646,-0.0021992817,0.10008959,-0.003580741,0.014807014,-0.04473918,0.06756587,0.00068163965,-0.040731505,0.06952662,0.07568063,-0.00428438,0.02188871,0.0686818,-0.013096298,0.051278375,0.047068138,-0.009901619,0.013276462,0.11503179,-0.00975652,0.014552039,0.035115883,0.04298557,-0.074936725,-0.13473566,-0.08587744,0.024219291,-0.082325764,0.016899837,0.02575469,0.019655598,-0.013696201,0.018918,-0.017121617,0.07339095,-0.001899111,0.003216292,-0.080465555,0.055497,0.0063682846,-0.002634229,-0.007479645,-0.05403415,-0.046134647,-0.08515529,-0.023878504,-0.01863933,-0.020366091,0.085592985,-0.06033034,0.03777092,-0.02579348,-0.04797242,0.0060549243,-0.012935135,0.048603248,0.038878325,0.056158848,0.026921308,0.06330943,0.034156498,0.062328238,0.052953083,0.016367957,0.040462438,-0.004641282,0.050769802,-0.058167845,0.01269855,-0.03614261,0.018640438,0.054657027,0.0018260648,0.06756428,-0.05243305,0.007278728,-0.07798335,-0.000107191125,0.04155292,-0.019821221,0.05626561,0.012485369,-0.037375707,-0.05434335,0.013054098,0.106813036,-3.574848e-08,0.0075429585,-0.0378226,0.049692053,-0.1013796,0.040909026,0.026088918,0.002475622,-0.09766018,0.075996585,-0.029641192,-0.02212737,0.042162385,0.01945393,0.035659783,0.048696052,0.0021553515,0.032453343,0.083470054,-0.04749251,0.005464312,-0.045401447,-0.048265915,-0.15406331,0.04716659,-0.024538167,-0.07042586,-0.0038424402,-0.0035401704,0.023050383,-0.015835222,0.042737976,-0.024856126,0.04872039,-0.06175646,-0.04843322,-0.004604156,-0.022567974,-0.0078191515,-0.05283975,-0.037350006,0.012611429,-0.017347848,-0.01673656,-0.02159791,-0.03728249,-0.03212689,-0.061603602,-0.034805093,-0.0021507193,0.018827075,0.011340561,-0.03545684,-0.0044510304,-0.10707264,-0.038043503,0.0704973,-0.0034122856,-0.039198186,-0.0637988,-0.087059975,0.034433343,0.0008550561,0.15505391,-0.059264477 +1.14.11.57,"Requires Fe2+ and ascorbate. The enzyme, isolated from multiple bacterial species, only produces trans-4-hydroxy-L-proline (cf. EC 1.14.11.56, L-proline cis-4-hydroxylase).",384,1.0,-0.027830215,-0.115341336,-0.10941206,0.03935223,0.04835595,0.041489173,-0.059374757,0.04634196,-0.023707971,-0.045206945,0.02965398,-0.03972856,-0.03143411,0.06356914,-0.045180783,0.023817284,-0.042924363,-0.07521511,0.011120848,-0.019591222,0.0812504,0.013323685,0.008589052,-0.015826594,-0.0050713797,-0.04404974,0.052913725,-0.032827597,-0.011721151,-0.082828335,-0.00077177596,-0.068125516,0.061625004,-0.07996042,0.08905325,0.021709831,-0.032990955,-0.026353594,0.09034213,0.045135327,0.0024204212,-0.045233067,-0.0041858056,-0.022385763,-0.0038964131,-0.046321843,0.044264995,-0.020381901,0.054410763,-0.005231326,-0.07012216,0.022102755,-0.061396465,0.054303013,-0.043928124,-0.019217802,-0.020887624,-0.05019123,-0.069863625,0.036088258,-0.022598242,0.009382729,0.01045521,-0.031315353,0.0011885732,-0.00447073,-0.026744366,-0.019351145,0.02762846,-0.0022922873,-0.049988758,-0.06715181,0.014020146,0.08288287,0.016574055,-0.009820885,0.046394408,-0.04659761,0.07572021,-0.023465168,-0.014130293,-0.021709153,-0.0221774,0.049475413,0.0072826394,0.0011366684,-0.015039043,0.045191403,0.0019573057,0.07681338,0.0018618862,0.027808823,-0.03326673,-0.031730674,-0.033412177,-0.01775985,0.027875599,-0.02259523,0.037621744,-0.049107976,-0.0649036,0.023945743,0.017993636,-0.08265319,-0.0606742,0.020047225,0.008251384,0.09820042,0.047836244,0.0012229517,0.05953363,0.0061058886,-0.004368615,-0.03264538,0.033848394,0.05503687,0.026638001,-0.105795704,-0.040679984,-0.012508124,0.032359034,-0.006526131,0.0693691,0.09401712,-0.06902541,0.09136486,-0.024951424,-2.0292713e-33,0.053418018,0.056306913,-0.0053888615,-0.02577564,-0.026990585,0.055300068,-0.114504375,-0.017132824,-0.051017005,-0.071065545,-0.044738162,-0.117589794,0.043235783,-0.00053521415,0.020100957,-0.057920095,0.046205565,-0.034564007,0.05292943,0.05003958,0.0138932625,0.07619089,0.014675558,0.012856653,-0.0024394179,0.027399631,0.048314884,0.041830696,0.032100208,-0.0050409967,0.0141408,-0.11305328,-0.04516028,-0.00088334305,0.10377749,0.027073214,-0.05024389,-0.04118146,-0.0028074854,0.040023483,0.017936856,0.10942434,0.024444379,-0.05527781,0.10374947,-0.06714796,-0.051698584,0.14707616,0.0062114736,0.088767625,0.011699654,0.053695016,0.07661328,-0.02807591,-0.022378208,0.023843491,-0.04675359,0.03859277,0.0959422,0.029206635,0.016291473,0.065531604,-0.056040864,0.05095317,0.03161898,0.04313587,-0.01439368,0.016010953,-0.019880153,0.08001076,-0.09978248,0.0014216419,0.044678632,-0.041137896,0.021492355,-0.05632104,-0.10901288,-0.00659507,0.08302083,-0.012615991,-0.039768387,0.03830307,0.022132482,0.036170583,-0.03570161,0.017233046,-0.0066505517,0.050068468,0.007632937,0.028617036,0.05685502,-0.070643,-0.040703107,0.022484649,0.01881458,-3.5728244e-34,0.063686796,-0.089941114,0.065655276,-0.07076241,-0.077832595,0.09616832,0.061064526,-0.101698324,0.013422593,0.05301941,0.084162645,0.02180947,0.020069897,-0.08820716,0.042284817,0.024506157,-0.076159894,0.08890745,0.024418108,0.0030503406,0.054769155,0.08608338,0.0015813934,0.057574213,0.055500735,-0.01305428,-0.008017182,0.10729895,0.012745143,0.013289636,0.048889372,0.02510984,-0.048528183,-0.143474,-0.0649748,0.01661527,-0.06268266,0.025570324,0.026050033,0.0021518501,-0.007816298,0.025580944,-0.009767642,0.07145153,-0.015988111,0.045737144,-0.062350128,0.017293282,0.03189562,0.029807689,-0.01566268,-0.06359796,-0.06938127,-0.095690325,-0.042131897,-0.042265505,-0.0034272585,0.074131094,-0.059094228,-0.031481158,-0.04732737,-0.10087786,0.054105807,-0.03920177,0.053536184,0.011935327,0.0067979624,0.024451429,0.056375507,-0.008896461,0.046675436,0.048862454,-0.020986322,-0.019037778,-0.019625252,0.04164456,-0.077497505,-0.028758433,0.0071188966,0.040030483,0.018213833,-0.006743744,0.027674427,-0.04481497,0.017927991,-0.08987176,0.023905478,0.05243428,0.0030260514,0.06369534,-0.022668548,-0.03387022,-0.036997203,-0.033629335,0.06645769,-3.774799e-08,-0.014917069,-0.0035932946,0.07112375,-0.04775783,0.010346064,0.016360598,-0.026367076,-0.079736836,0.07030842,-0.061079502,-0.028922416,0.06993111,-0.016460743,0.00094585546,0.053139467,-0.025696844,-0.027974682,0.052194998,-0.03450179,-0.012673584,-0.08952534,-0.04865244,-0.15148288,0.059146054,-0.012466198,-0.07405958,0.008264354,0.001811254,0.038996052,-0.038090255,0.031010082,-0.003173851,0.0028129516,-0.0757666,-0.063832745,-0.01671238,-0.027568875,0.006918187,-0.0390875,0.04609982,0.02741712,-0.024019465,-0.037996408,-0.0015075471,-0.020216465,0.03190068,-0.057651613,6.1427214e-05,-0.032514915,0.04439677,0.04463207,-0.052809913,-0.012195609,-0.057958137,-0.052510414,0.08630265,-0.007674227,-0.073514424,-0.02377325,-0.069883466,0.061899338,0.007226257,0.20639177,-0.05363603 +1.14.14.38,"A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses two successive N-hydroxylations of L-valine, the committed step in the biosynthesis of the cyanogenic glucoside linamarin in Manihot esculenta (cassava). The product of the two hydroxylations, N,N-dihydroxy-L-valine, is labile and undergoes dehydration and decarboxylation that produce the (E) isomer of the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The enzyme can also accept L-isoleucine as substrate, with a lower activity. It is different from EC 1.14.14.39, isoleucine N-monooxygenase, which prefers L-isoleucine.",384,0.99999994,-0.08806833,-0.03767582,-0.06898106,-0.021435319,0.06773184,0.052193798,-0.06644519,0.06867745,-0.028247457,-0.06416389,0.019267458,-0.027172754,-0.04229791,-0.012165648,-0.06732668,-0.016177483,-0.013647107,0.020243067,-0.025300572,-0.05946155,0.016076477,0.006196183,-0.04062619,0.0037915597,0.049522888,-0.006689512,0.050824367,0.012023431,-0.03847752,-0.09983341,0.004871021,-0.025056431,0.034852058,-0.05358499,0.016187636,0.06912545,-0.036711957,-0.063178055,0.018083844,0.009473847,0.027277347,-0.0591664,-0.055560324,-0.0102688745,-0.0044292067,-0.12197909,-0.031232666,-0.002201971,-0.02255093,-0.012503902,-0.014406653,-0.04271093,-0.06593051,0.029244604,-0.05508893,-0.0655402,-0.00814615,0.013730684,0.0017864517,0.037116677,0.0016914556,0.0625194,-0.075593375,-0.01681423,0.010901197,-0.0787767,0.031076638,-0.08176066,0.012495197,-0.08226288,-0.009997635,-0.08485736,-0.04623427,0.015954414,-0.12833859,0.08255835,-0.015864434,0.026938511,-0.036349826,0.05761191,0.011678645,0.051301345,0.01719382,0.07219692,0.029367225,0.014269096,-0.08162536,0.09009068,0.008200372,0.009590903,0.028008834,0.023811078,-0.03268389,0.059756335,-0.026829267,0.056839984,0.08230964,0.032333016,-0.008835295,0.009618037,-0.03862653,0.05091543,-0.118521415,-0.047405194,-0.032167796,0.03534329,0.021124626,0.07324193,0.04076081,-0.04609396,-0.05398769,-0.0024926434,-0.00081648695,0.00029975892,-0.049337734,0.114747666,0.03826874,-0.047604047,-0.010896136,-0.052222375,0.049204864,0.005399659,0.06250658,0.06299549,-0.04219672,0.013716527,-0.025593068,4.0816327e-33,0.087913446,0.001033481,0.048592985,0.025351599,-0.01904775,0.012456207,-0.09399391,0.057422277,-0.0052776113,-0.06362974,-0.07941746,-0.010258235,0.044145394,0.017997704,-0.034761477,0.013760928,-0.0073127886,0.032195617,0.0426631,-0.020562023,0.010895678,-0.011431992,-0.066464044,0.027867105,-0.054002956,0.09785945,-0.00242546,-0.02018911,-0.005785226,0.035055302,-0.05391783,-0.107644945,-0.00870703,0.045697942,0.0184956,0.016724795,-0.033630043,-0.0019410041,-0.012428415,0.08252373,-0.024012325,0.008806369,0.015557278,-0.07283703,0.07692616,-0.07170958,-0.06001934,0.05443338,-0.034843627,0.041851383,0.062777504,-0.0047956803,0.054687787,0.041029755,-0.039201465,0.08271166,-0.0102765495,0.02471769,0.046140015,0.10328093,0.105144784,0.1068872,0.019751837,0.028181566,-0.0047650295,0.051268406,-0.13279654,-0.05044794,-0.0063020084,0.104030505,-0.06845705,-0.005529477,0.10448573,0.023847016,0.10065986,-0.062961414,0.024598619,0.09186878,0.021899562,-0.017670609,0.022173857,0.051917568,-0.009159911,-0.027364012,-0.009151624,0.005413777,6.8377294e-06,0.00804761,-0.028590346,0.099091515,0.016662274,-0.031480785,-0.017472735,0.004304361,0.0194777,-3.9382532e-33,0.123175785,-0.06899768,-0.035903975,-0.057487767,-0.041397564,0.007895381,0.018579962,-0.025354294,-0.00024907314,0.0009031575,0.071872056,-0.051356886,-0.016126936,-0.008918186,-0.017962016,-0.0043567666,0.028593369,0.04995156,-0.031737864,0.027868683,-0.041368302,0.056689873,-0.017806884,0.0003101567,0.067178525,-0.05262535,0.026952576,0.030295007,0.03665231,0.06514748,-0.05640063,0.010335106,-0.060104217,-0.037757628,0.010027016,0.08702501,-0.04658033,0.011034276,0.037261114,0.07003065,-0.057134576,0.033858806,-0.012043396,0.030197209,0.08958729,0.06294733,-0.08050169,-0.059826247,0.025688784,-0.034008235,0.09395574,0.008884665,-0.03968148,0.06874686,0.031034222,0.03806966,0.027663711,0.03800311,0.042555954,-0.02085937,0.029993374,-0.017756542,-9.845483e-06,-0.02307029,0.062436774,0.053889528,-0.015579451,0.08182299,0.0046333675,-0.026398288,0.1263757,-0.06857419,0.055675976,0.07861106,0.00039345495,-0.057096925,-0.0090531465,-0.06345709,-0.036292307,-0.075305484,-0.0075011738,-0.033297505,-0.027082218,-0.13864389,-0.027168864,-0.049480945,-0.030319411,0.085958734,-0.0028080957,-0.017611964,-0.02112927,-0.034467015,-0.050511617,0.066223815,0.14132811,-5.0483848e-08,0.008355457,-0.059421368,-0.036388375,0.03560219,-0.014762733,0.05629445,0.05734085,-0.02811008,0.0797502,-0.048777156,-0.0015146628,0.08435183,-0.00789792,0.019298173,-0.0068326914,0.060631227,0.0021508385,0.0025205172,0.019154472,0.07633809,-0.021101702,0.021991098,-0.043933097,-0.050466932,-0.028629458,-0.09123025,0.01787529,0.07063841,0.10851986,-0.060083598,0.014666202,0.048218824,0.039959215,-0.044691868,-0.035661474,0.028242525,-0.035015684,-0.009204956,0.01924701,0.011691411,-0.070974045,-0.059875086,-0.082527444,-0.030774595,0.018488087,0.012661554,0.052841317,0.021805122,-0.051534887,0.04424565,0.051463712,-0.021662785,0.038011465,-0.08861005,-0.039559018,0.035989698,0.02942518,-0.08954337,0.010059293,-0.08483784,-0.004547839,-0.031601314,0.19133432,-0.016280163 +1.14.14.39,"This cytochrome P-450 (heme-thiolate) enzyme, found in plants, catalyses two successive N-hydroxylations of L-isoleucine, the committed step in the biosynthesis of the cyanogenic glucoside lotaustralin. The product of the two hydroxylations, N,N-dihydroxy-L-isoleucine, is labile and undergoes dehydration followed by decarboxylation, producing the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The enzyme can also accept L-valine, but with a lower activity. cf. EC 1.14.14.38, valine N-monooxygenase.",384,1.0,-0.08032808,0.009298902,-0.03234515,-0.024718363,0.045929335,0.04882059,-0.081204474,0.06805755,-0.02595286,-0.08279943,0.013815891,-0.024217386,-0.047456518,-0.0058857375,-0.07880972,0.051390782,-0.03745751,0.00214361,-0.025823144,-0.036647897,0.04369144,0.04787085,-0.032099683,-0.0068235374,0.050974924,-0.022374908,0.043127593,0.026860395,-0.0035321699,-0.05774331,-0.0037310773,-0.011763627,0.021702,-0.045298677,0.041469194,0.08305327,-0.08605236,-0.06417641,0.028899863,0.029947419,0.02996262,-0.049597587,-0.047022548,0.01480054,-0.053889897,-0.06474362,-0.03241808,0.020666143,-0.015555011,-0.0121000735,0.006143838,-0.07784455,-0.027182156,0.03755219,-0.04455635,-0.045913614,-0.019133158,0.03381889,-0.03732453,0.007032275,0.012170553,0.082546555,-0.07983068,-0.017895369,0.019300887,-0.028478477,-0.015801406,-0.067018144,0.0062020672,-0.09367133,0.014996197,-0.08799193,-0.06527134,-0.008297889,-0.1111997,0.06326292,-0.05308405,0.019650407,-0.0063097975,-0.017389031,0.04869958,0.032315794,-0.010814375,0.06491459,0.043653872,-0.012749408,-0.054240704,0.105622426,0.022168284,0.010476048,0.03402438,0.02191276,-0.033218212,0.049763206,-0.011536014,0.08194412,0.06650267,0.041514866,0.016967682,-0.029537302,-0.007330338,0.030199187,-0.056596737,-0.07192758,-0.054512464,0.05271943,0.01832434,0.05531844,0.066347845,-0.056970265,-0.07228906,-0.010692213,0.038366076,0.03657352,-0.026179846,0.11746075,0.062406838,-0.03875066,-0.057856556,-0.048621222,0.026517887,-0.0427484,0.05400476,0.049231943,-0.03079078,0.050124664,-0.051980585,3.9665764e-33,0.11301224,-0.019679403,0.021907697,0.014127763,0.021909473,-0.0020166729,-0.06954991,0.019413646,-0.017096484,-0.03587901,-0.11990382,-0.028849946,0.0008151248,-0.002384233,-0.04281056,-0.044847757,-0.020920474,-0.00034483735,0.060029306,-0.0014716639,0.0010241204,-0.025841307,-0.05785094,0.0495297,-0.06766701,0.08980284,0.032257304,-0.0045849783,0.029207354,0.0014413287,-0.04285325,-0.11860524,-0.02472491,0.0051472145,-0.004583021,0.008803697,-0.022985894,-0.006126764,-0.012296991,0.07128347,-0.010693068,0.014355857,0.03418532,-0.075973146,0.060987577,-0.03993528,-0.1039199,0.059417125,-0.011935166,0.064110756,0.07357874,-0.04069017,0.026895506,-0.007743933,-0.039647438,0.04073086,-0.02250272,0.070365526,0.07475692,0.0929522,0.09675686,0.12616067,0.050688323,0.039538883,0.0027381533,0.004883848,-0.09308348,-0.017975679,-0.053292677,0.097275645,-0.05132589,-0.04540529,0.086618826,0.005185619,0.10132631,-0.07484849,0.020685043,0.08906427,0.043240316,-0.028814109,0.048362475,0.044402596,-0.006787346,-0.013230967,0.01093894,0.0027921773,-0.015722513,-0.022241106,-0.028459664,0.12164516,0.0021283804,-0.036589246,-0.017320726,0.01105689,-0.0051350724,-3.929033e-33,0.09954486,-0.095050156,0.024099555,-0.076848395,-0.026419293,0.045428053,-0.023583546,-0.010479066,0.040228106,0.03325655,0.081204556,0.0033285962,0.019907812,0.007637839,0.026563123,-0.03233084,0.021634053,0.07853848,-0.056269653,0.026541911,-0.0037184672,0.021290269,-0.05648688,0.0068154647,0.03965478,-0.023208788,-0.0036151097,0.07537053,0.06330513,0.06120821,-0.050512426,0.06036698,-0.08010003,-0.06052021,0.020859353,0.06430609,-0.00022322478,0.017986106,0.015804041,0.035220265,-0.06351391,0.016719108,0.00030224794,0.05348492,0.06455506,0.035774004,-0.10195654,-0.1278384,0.016347092,-0.035901092,0.0635817,0.021730648,-0.019073237,0.077946864,0.016112937,0.069885634,0.009099586,0.04191709,0.06540044,-0.045276448,0.009331532,-0.03191609,-0.016127333,-0.029671954,0.029372988,0.055643294,-0.042861227,0.08021558,0.041994087,0.008861085,0.077063754,-0.018478692,0.018550148,0.080860265,-0.01469852,-0.024623387,-0.0095144175,-0.04627871,-0.009139065,-0.056560706,0.02402507,0.0051950626,-0.0263297,-0.13532087,-0.04782694,-0.100079104,0.00098034,0.11254545,0.003951114,-0.02113139,-0.016266001,-0.031237138,-0.06854596,0.05293757,0.10016014,-4.676932e-08,-0.030096188,-0.08944314,0.022150856,0.01060084,-0.0042661596,0.002019795,0.0717858,0.020826273,0.06620199,-0.0791115,0.008293383,0.06978432,-0.024840351,-0.0058971928,-0.012881246,0.040104415,-0.0009300222,0.017012699,0.018490609,0.07580377,-0.0077188704,0.020594202,-0.023786651,-0.020224256,0.00018315457,-0.098783866,0.037090477,0.062390942,0.06652629,-0.05634563,0.050598193,0.06529011,0.017692687,-0.071933694,-0.056342185,0.022815065,-0.031830106,-0.028280018,0.008377476,-0.025503263,-0.055491,-0.07134574,-0.073681824,-0.009154743,0.028537545,-0.04686772,0.054596126,0.0073083625,-0.012916626,0.04308272,0.034106594,-0.029450947,0.02325967,-0.10612441,-0.033500686,0.017727202,0.037760258,-0.04863864,-0.022897637,-0.12623614,-0.011665147,-0.0098218275,0.21527661,-0.003324521 +1.14.14.40,"This cytochrome P-450 (heme-thiolate) enzyme, found in plants, catalyses two successive N-hydroxylations of L-phenylalanine, a committed step in the biosynthesis of benzylglucosinolate and the cyanogenic glucosides (R)-prunasin and (R)-amygdalin. The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is labile and undergoes dehydration followed by decarboxylation, producing an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme.",384,1.0,-0.09600127,-0.011007411,-0.047919653,0.003519355,0.080160275,0.041979507,-0.07046882,0.04821733,-0.010945424,-0.02322204,0.0372863,-0.0046543856,-0.073534,-0.0004458214,-0.080381215,0.07357542,-0.11593559,0.011770002,-0.0121015115,-0.015563839,0.017675841,0.035130333,-0.05886396,0.039633874,0.07467767,-0.03357962,0.06450454,-0.005496647,-0.037271537,0.0049277735,-0.011446127,-0.04758012,0.0065553007,0.025807371,0.02003751,0.10106848,-0.10038907,-0.0917083,0.057156857,-0.012962962,-0.0040109297,-0.09797481,-0.07210417,0.009796935,-0.01056745,-0.032509927,-0.03264896,0.037185304,-0.017940043,-0.047880232,-0.0020213441,-0.012233145,-0.016845187,0.0038044127,-0.056852087,-0.043014757,-0.00824772,0.013781826,-0.03361781,0.030044159,-0.011527857,0.061727483,-0.09002869,-0.005038207,-0.009548371,-0.04539647,-0.03875843,-0.0595271,0.057963185,-0.073074505,0.0020141033,-0.08019258,0.017608665,-0.05704465,-0.07569676,0.021228116,-0.03228268,0.05585285,-0.009209266,0.01886201,0.09471608,0.027834062,0.03276924,0.05720277,0.06624553,-0.013465499,-0.060603134,0.09262469,0.022321785,-0.036605366,0.026567725,0.010303419,-0.07146112,0.06526495,-0.072913885,0.077219345,0.038763747,-0.016344063,-0.0050699054,0.004540014,-0.024256758,0.050175346,-0.015883395,-0.1248297,-0.05494683,0.047334734,0.0070445403,0.055668924,0.051573362,-0.025101595,-0.051090244,-0.024547266,0.02283285,0.022811037,0.015008278,0.14066964,-0.053341787,-0.02752532,-0.0038244892,-0.053447,-0.024814166,-0.011760806,0.047273714,0.016739167,-0.046371926,0.047120333,-0.09279733,4.474828e-33,0.12652692,-0.053427555,-0.0010441011,0.015133289,0.04187547,-0.0019977402,-0.0869479,0.035956427,0.031404424,-0.041520324,-0.09397457,-0.08677099,-0.014021074,-0.014227239,-0.07622706,-0.025828524,-0.043679584,-0.00704565,0.10066877,0.032037944,-0.010675139,-0.008592099,-0.061517775,0.027440362,-0.033216212,0.07461721,-0.013694858,-0.0013522954,0.033166442,0.008942845,-0.028779466,-0.1494035,-0.042924244,-0.027592305,-0.017849674,0.013595294,-0.08817219,9.820478e-05,-0.040636215,0.09343377,-0.0054424,-0.015817383,0.029866824,-0.057473004,0.03464159,0.047251455,-0.06393481,0.064718455,-0.070312,0.057136714,0.059708737,-0.008007966,0.039045945,0.034095947,-0.032145593,-0.01573712,0.029865302,0.016149687,0.060115825,0.051476162,0.08471557,0.066104956,0.028424924,-0.008636652,0.019970503,0.033872604,-0.081435785,-0.0008683806,-0.0075341193,0.08160016,-0.054835066,-0.04630106,0.12050968,-0.026497677,0.072392486,-0.07658479,0.03956636,0.086844735,0.06439829,0.0094099995,0.034131885,0.007408704,-0.04072537,-0.008317694,-0.0063848677,0.016649604,-0.02259838,-0.049173776,-0.030441226,0.08708722,0.0070667174,-0.07619775,0.039069366,-0.010102593,0.021653416,-4.726606e-33,0.091427095,-0.09868912,-0.00022053598,-0.057553492,-0.0078470865,0.023845617,0.0041135494,-0.0074799196,0.022595739,-0.0060394546,0.05958454,-0.005009284,-0.011233152,0.055788677,0.030131632,0.03858419,0.028712891,0.07714267,-0.0008988184,0.037421376,-0.012864837,0.08604951,-0.0027818019,-0.0013823346,0.08209039,-0.01609937,0.020808998,0.0531168,0.07495056,0.046823177,-0.06675057,0.050580148,-0.06664877,-0.002909087,-0.022299476,0.07571939,-0.032547105,-0.028373836,0.02203759,0.07367832,-0.016075669,0.017673526,-0.014434896,0.07754422,0.063034244,0.05723211,-0.09222734,-0.07590812,-0.027154975,-0.055300537,0.050332315,0.06357037,-0.046141736,0.0039525987,0.0066730436,0.07005248,0.006611286,0.024703396,0.007099511,-0.026626639,-0.046581972,-0.10911173,-0.02845007,0.011800919,-0.013325781,0.064618684,-0.0047779186,0.095941775,0.07255739,-0.019209897,0.03790853,0.0016372991,0.03707418,0.12376155,-0.03508161,-0.04019814,0.003950189,-0.05553098,0.0114576705,-0.055244632,-0.025954861,-0.05286513,-0.02452413,-0.09072492,-0.0119248135,-0.103178136,0.0061095716,0.076008655,0.0030268887,-0.024711998,0.0137230335,0.039636943,-0.015420476,0.07593403,0.10668505,-4.4098496e-08,-0.02357394,-0.12472011,0.026724922,-0.0019793098,0.068396494,0.020183913,0.06729039,0.02699025,-0.010237493,-0.08901989,-0.01026151,0.08571536,-0.07245547,0.03454892,0.004025201,0.011392162,-0.007971478,0.032855038,9.541602e-05,0.03350843,-0.034447324,0.023962084,-0.062202286,0.020596894,-0.019595634,-0.069687076,0.058245543,0.04780265,0.01954857,-0.05149563,0.035465267,0.0711449,-0.0033958585,-0.020006886,-0.002431775,-0.009358141,-0.013821047,-0.030304294,-0.026147814,-0.036049478,-0.062086053,-0.045901563,-0.035188932,0.0036557538,0.019671641,-0.01466707,0.052599207,0.016582377,0.02587681,0.0382898,0.059810195,0.014034753,0.020206975,-0.08856203,-0.03379089,0.011342054,0.012437518,-0.016692944,-0.05031795,-0.08648903,-0.016225932,0.04138684,0.20354007,-0.058238212 +1.14.14.41,"This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucosides lotaustralin and linamarin. It catalyses three different activities - isomerization of its substrate, the (E) isomer, to the (Z) isomer, dehydration, and C-hydroxylation.",384,0.9999999,-0.09865844,0.031780664,-0.066902176,-0.013334563,0.044522263,0.037531618,-0.025164954,0.07298923,-0.048955556,-0.03594795,-0.0013201234,-0.010532062,-0.04773975,0.022842564,-0.06494788,0.020862477,-0.043478455,0.027105197,-0.058849674,-0.0730129,0.017907565,0.016619844,0.0042731836,0.045863055,0.021266475,-0.00015120563,0.06385782,0.05867803,0.018524544,-0.03735708,-0.07058684,-0.012550409,0.05930239,-0.04522269,0.005470032,0.07779113,-0.10144698,-0.062518515,-0.0073878053,-0.06077837,0.10937284,-0.05449017,-0.08306535,0.016094264,-0.053520944,-0.058913592,-0.0130539555,0.006380153,-0.012506407,0.0044078715,-0.01267084,-0.06553065,-0.068809606,0.023276413,-0.04874432,-0.02970977,0.02823427,0.0324611,-0.0052558933,-0.021188807,0.00014324542,0.056331262,-0.08578542,0.022270681,-0.0012892671,-0.07085727,0.009716009,-0.023569757,-0.04448657,-0.07686268,-0.0038299528,-0.09281908,-0.07947351,-0.012808284,-0.07627848,0.07176918,-0.017857801,-0.02473678,-0.02646545,0.012921122,0.07543052,0.015654111,0.019030828,0.09832174,0.034157693,0.04165884,-0.074210905,0.041936457,-0.028301165,-0.014478058,0.044698857,0.03402383,-0.017743342,-0.033879403,-0.07976943,0.083645895,0.058393117,0.0024098665,0.0664014,0.0003955161,0.03677201,0.06005093,-0.0078065987,-0.097537816,-0.038434252,0.031020954,0.0094954,0.092229135,0.07171573,-0.052730672,-0.06678458,-0.0141920075,0.020004792,-0.009057163,-0.053551897,0.09831205,0.053848766,-0.016953038,-0.026851103,-0.012516433,-0.01797342,-0.026797188,0.044035837,0.06551853,-0.009367043,-0.0477088,-0.06537002,1.8192193e-33,0.09178965,-0.009511627,-0.010560133,0.0005657929,-0.0030473971,0.0028001259,-0.07064575,-0.028088473,-0.047287345,0.03576227,-0.11843122,-0.057905648,-0.0007054604,0.01370499,-0.03940624,-0.032617863,-0.030883214,0.043891016,0.047189746,-0.0055343793,0.024795575,0.033495214,-0.0757509,-0.0034561495,0.0014302835,0.14406104,0.0013155449,0.021356363,0.010758496,-0.019793084,0.008294844,-0.012240551,-0.08491568,-0.014383363,0.027059903,0.0049957875,-0.03118749,-0.012265118,-0.0011338603,0.04946358,-0.031609647,-0.019134786,-0.0031608245,-0.09661842,0.07052402,-0.010182542,-0.07781745,0.023355352,0.03647533,0.027465375,0.084565535,-0.0627137,0.1011731,0.07386547,-0.0796501,0.031087292,0.012689252,0.0039978866,0.06752123,0.060628228,0.1299343,0.08468861,0.01569707,0.07480059,0.038462467,0.0440785,-0.05937051,-0.012580271,-0.032912243,0.10345661,-0.04762787,-0.00153754,0.091226265,0.015853021,0.09521608,-0.029121168,0.008696791,0.076497346,0.021474158,-0.012569242,0.005787461,0.016039472,-0.0039540883,-0.0065855095,-0.0016943869,0.01190678,-0.05187441,-0.00665409,-0.012925067,0.09005124,0.04042009,-0.0644562,-0.02502646,0.04437923,-0.039264996,-2.3788885e-33,0.07416787,-0.053434458,0.047401894,-0.10863753,-0.04179107,0.034088954,-0.036463115,-0.005972098,-0.048282422,0.04134278,0.10197922,-0.00023246348,-0.009702676,0.0056793257,-0.027873527,-0.008357387,0.00037005584,0.059552938,-0.06772882,0.023888418,-0.019704577,-0.0077420515,-0.0047944956,-0.02683392,0.03667596,-0.013900078,0.023959834,0.02418162,0.10741461,0.06408645,-0.071901165,0.025962068,-0.07230559,-0.088828444,-0.013242673,0.04914139,0.013162377,0.09305879,0.019864349,0.01310121,-0.07545731,0.026078653,0.018405396,0.04352238,0.07298743,0.10193234,-0.06285733,-0.10108624,-0.012819487,-0.04835291,0.09235189,0.07471127,-0.00773179,0.05813752,0.049331684,0.044092823,0.0459621,-0.01542892,0.0054592313,-0.087542,-0.030575462,-0.013290804,0.004048398,-0.015236955,0.06804117,0.103730254,-0.04589386,0.05057633,-0.02952255,-1.802925e-05,0.06768906,-0.053302914,0.04125393,0.08671347,0.016702648,-0.023300206,0.025577683,-0.062225997,0.012599388,-0.007615548,0.028907709,-0.03592345,-0.06839091,-0.084703274,-0.07838695,-0.10625542,-0.031720486,0.08241572,0.017449928,-0.038141817,-0.047838382,0.05051883,-0.015155165,0.046033345,0.05034415,-4.0160888e-08,-0.022496408,-0.10030356,-0.0036949348,-0.02912327,-0.029146753,0.014499136,0.055154406,0.034691647,0.060506873,-0.03723243,-0.018041207,0.08307831,-0.018743947,-0.038953662,0.013992829,0.044538643,-0.0011443127,-0.024842203,0.05913737,0.015579171,-0.04378704,-0.004155646,-0.046560176,-0.0066651474,0.034519453,-0.10922201,0.012289684,0.0747725,0.040597543,-0.014071308,0.03962601,0.09104124,-0.009058657,0.004297985,-0.014349365,0.023794191,-0.05802819,-0.050079603,-0.018593712,-0.041772246,-0.044400457,-0.06792473,-0.04919765,-0.0014431219,0.016054656,-0.017526533,0.08236137,0.014838579,0.042013068,-0.0061612227,-0.015346609,0.0002393257,0.0064100893,-0.108349465,-0.043926645,0.006965481,0.10089943,-0.043808457,0.0034047838,-0.07212061,0.03986626,-0.03283916,0.1855449,-0.02464448 +1.14.14.42,"This plant cytochrome P-450 (heme thiolate) enzyme is involved in methionine-derived aliphatic glucosinolates biosynthesis. It catalyses two successive N-hydroxylations, which are followed by dehydration and decarboxylation. CYP79F1 from Arabidopsis thaliana can metabolize mono-, di-, tri-, tetra-, penta-, and hexahomomethionine to their corresponding aldoximes, while CYP79F2 from the same plant can only metabolize penta- and hexahomomethionine.",384,0.99999994,-0.08277707,0.007849859,-0.051793136,0.00046280635,-6.2426756e-05,0.042326514,-0.06126601,0.09167186,-0.014682369,0.009734768,0.02342011,-0.030656083,-0.046891697,-0.015118839,-0.058781713,-0.007877252,-0.03558162,0.03045156,0.00020548965,-0.085085556,0.044776984,0.07196746,-0.033253197,-0.012327765,0.06929019,-0.01738814,-0.024105012,0.07339438,-0.011177875,-0.069725364,-0.062884815,0.054292668,0.009526123,-0.02096273,0.0034341323,0.14063875,-0.033846587,-0.04849813,0.02186386,-0.028886054,0.06949063,-0.018215746,-0.045587108,-0.0011015999,-0.026348496,-0.029920684,0.00030595582,0.038188975,-0.003251941,-0.03908189,-0.039249893,0.03263974,-0.03263388,0.009192519,0.03759716,-0.07209471,0.03292278,-0.02524797,-0.042662498,0.0116764195,0.004607177,0.0055604833,-0.06649118,-0.0073192543,-0.008562888,-0.054134935,-0.036695942,-0.0333029,0.041906204,-0.06859785,0.009489981,-0.021796731,-0.054580923,-0.029816335,-0.06353863,0.10862586,-0.07964778,-0.0032454738,-0.057080887,-0.048096456,0.12279926,0.053063657,0.056540754,0.092307426,0.07053644,-0.025554946,-0.085496,0.0929857,0.0105942,-0.002045519,0.012660142,0.05919179,0.00786487,0.013887681,-0.10547618,0.084431164,0.01396773,-0.02863645,-0.054995794,-0.011103307,0.049867127,0.069500364,-0.039493144,-0.063921526,-0.0015542257,0.011848323,-0.0069408063,0.07617772,0.0090986965,-0.029481042,-0.04255083,-0.026995413,-0.020298004,-0.045399047,-0.047650374,0.10572895,-0.0075542834,-0.03590671,-0.010502714,-0.021922277,-0.039908174,-0.039436173,0.013412848,0.020982366,-0.019448115,0.009431636,-0.11853724,6.176752e-33,0.06287586,0.031407192,0.0110654365,0.009862374,0.03503922,-0.025758486,-0.075817876,0.007142341,-0.010422536,-0.06562056,-0.056984674,-0.050894216,0.0002135659,-0.008045716,-0.06011542,-0.04118758,-0.09086848,-0.0020537912,0.09682397,-0.007026507,0.016710682,-0.05320533,-0.12862371,-0.012542372,-0.023146281,0.060498334,-0.00640929,0.04643074,0.002569074,-0.022255305,-0.071403034,-0.061359722,0.00259146,-0.036215194,0.014050621,-0.033565503,-0.07024187,-0.049573645,-0.053156976,0.10687495,-0.03271903,-0.00053641846,0.045331754,-0.117106915,0.06475063,0.03767549,-0.14093144,0.042173423,-0.008697195,0.07841508,0.09570413,-0.023396725,0.09201728,0.048684858,-0.07168621,0.028955096,0.0029364252,-0.008239397,0.036466397,0.096676975,0.04704767,0.03374756,-0.06596894,0.0273552,-0.026199495,0.046822358,-0.09478705,-0.047124427,-0.037385758,0.14750811,-0.033888098,-0.0588372,0.055774216,-0.0052811056,0.05488643,-0.02059165,0.018988688,0.088787645,0.04393699,0.04516452,0.08126077,0.00666873,-0.0067130784,0.02875607,-0.053821117,0.0050542546,0.003987796,-0.03576688,0.011396876,0.05003224,0.020684276,-0.03437819,-0.02650541,0.0014653009,-0.0057040667,-5.966583e-33,0.07416873,0.009613911,0.04327658,-0.073060654,-0.01917195,0.03750568,-0.0031836436,-0.09083537,0.032924198,-0.015162985,0.10561387,-0.028798828,0.00618075,-0.0165399,-0.003897485,-0.056018203,0.04367615,0.0890132,0.00051992777,0.078423046,-0.038035963,0.03309132,-0.029621629,-0.0294474,0.046829294,-0.040544108,0.028759768,0.032385,0.06989444,0.05822331,0.008835283,0.032372642,-0.08667216,0.019712187,-0.022414204,0.049736027,-0.07207865,0.031627957,0.057227813,0.063829795,0.0037605192,0.03996667,0.05570713,0.05742012,0.06327548,0.011416776,-0.07257464,-0.037437186,-0.026300594,-0.03652767,0.06354259,0.04850565,-0.087613225,0.06200561,0.01270353,0.058078144,0.103159525,-0.007200158,0.013394442,-0.05969965,-0.017695185,-0.06706049,0.010539515,0.007756662,0.022723049,0.06971847,-0.0060201664,0.045087818,-0.011207654,0.053057067,-0.0023961042,0.010885787,0.035840835,0.038198415,-0.014282617,0.0024750426,-0.052002933,0.013010859,-0.048954096,0.013869942,0.04283787,0.0013337376,-0.047476493,-0.07547129,-0.025053605,-0.08354755,-0.009572838,0.13796197,0.05553661,0.009076725,-0.020617856,0.026483154,-0.022689411,0.03682849,0.024676358,-4.431201e-08,-0.044682328,-0.11025563,0.011980276,0.0043266458,-0.031913653,-0.010276824,0.041120067,-0.051774614,0.071763106,-0.04181025,0.014274677,0.072909445,-0.0068667973,0.023627631,0.0058824457,0.054642525,0.01986113,-0.0014299683,0.045296706,0.054552566,-0.09807353,0.0041134567,-0.06026665,-0.00790292,-0.0047939518,-0.09660886,0.024345964,0.011322404,0.11585251,-0.04111572,0.06558916,0.034710698,-0.03944378,-0.04974,-0.021970097,-0.04675268,-0.03246857,-0.034051254,-0.00024687234,-0.03263203,-0.020441866,-0.011056441,-0.07034461,0.034510586,0.04698294,-0.005617022,0.033089828,0.046944875,-0.010249415,0.05614445,0.009005429,0.042427972,0.07056797,-0.13601916,-0.01115806,-0.021461273,0.043094967,0.009202187,-0.030749662,-0.07969825,-0.011946811,-0.016639002,0.2061871,-0.019159853 +1.14.14.43,"This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of glucosinolates in plants. The enzyme catalyses an N-hydroxylation of the E isomer of omega-(methylsulfanyl)alkanal oximes, forming an aci-nitro intermediate that reacts non-enzymically with glutathione to produce an N-alkyl-thiohydroximate adduct, the committed precursor of glucosinolates. In the absence of a thiol compound, the enzyme is suicidal, probably due to interaction of the reactive aci-nitro intermediate with active site residues.",384,0.99999994,-0.080801085,0.034717686,-0.07737896,-0.017219968,0.09425771,0.02299664,-0.082410775,0.12051926,0.033994474,-0.03147871,0.074855104,-0.024335468,-0.037833948,-0.02092039,-0.082954295,0.025828052,-0.043979235,-0.01528823,-0.08576322,-0.1216874,0.02718884,0.0472649,-0.038613364,-0.032479268,-0.017992215,-0.05118276,-0.0034711268,0.02727623,0.0010181761,-0.025743049,-0.088365145,-0.011056639,0.009716415,-0.00294658,-0.01952271,0.07171072,-0.06287246,-0.031443134,0.044270214,-0.05620979,0.051688112,-0.054128718,-0.068208374,0.036298674,-0.013335677,-0.07794347,-0.013644373,0.04975433,-0.014387937,-0.0014404545,-0.019354569,-0.05003914,0.015105398,-0.008677934,-0.03213571,-0.046506632,0.022783194,-0.012568372,-0.0046623535,0.009137078,0.030409532,0.029779501,-0.08171368,-0.019195128,0.004215874,-0.048969965,0.046962902,-0.020900331,-0.041323565,-0.015292511,-0.0082944175,-0.07446928,-0.038044598,0.028338475,-0.037459996,0.08572011,-0.065436676,-0.037205707,0.023080789,0.017449023,0.0788552,0.041056093,0.05735691,0.0803772,0.0640143,-0.011281469,-0.043525532,0.10294883,0.012441607,-0.015770825,-0.027210351,-0.004165901,-0.046741884,0.024068886,-0.078268334,0.09824663,-0.002711,-0.02841815,-0.039536405,-0.055946257,0.028331218,0.039422557,-0.016520254,-0.051164128,-0.06426096,0.031188874,-0.049938697,0.060174607,0.055222876,-0.018528285,-0.06928499,-0.017145557,-0.04496018,-0.0370057,-0.044041008,0.11608101,-0.007020082,-0.042880338,-0.09020405,-0.048602015,0.012598401,0.005924487,-0.032342944,0.048401374,-0.040569402,-0.010292467,-0.03345427,3.7566004e-33,0.09311913,0.032981556,-0.004676806,-0.018324368,0.09345672,-0.03162052,-0.083952986,-0.0057282043,0.008634457,0.024326196,-0.06715692,-0.10412596,-0.035051163,-0.040882464,-0.03144206,-0.00761312,0.00675794,0.02315251,0.040139854,0.023083594,-0.0022873918,-0.005412654,-0.077637956,-0.037894282,-0.04082253,0.111623645,-0.02810479,0.023729807,0.017021667,-0.0075288834,-0.02256996,-0.10658134,-0.029774245,-0.020425713,0.033131234,-0.051345907,0.0023163029,0.0042320285,0.0011563262,0.03861172,-0.035903204,0.049961362,0.020779556,-0.046982523,0.085040405,-0.026361616,-0.11450868,0.05858866,0.005228894,0.14492483,0.02028677,-0.04737175,0.09817486,0.05180929,-0.02950628,0.028775027,-0.01728905,0.004436182,0.04106941,0.033962473,0.09357754,0.06604253,-0.0433882,0.048117895,-0.032280676,0.040552586,-0.07245257,-0.033632603,0.015327873,0.17085752,-0.050029293,-0.017236095,0.02053293,0.0055415174,0.058499213,-0.08257894,0.020136382,0.097182855,0.021714207,0.04771633,0.062095884,0.036299597,-0.020752389,-0.007869236,-0.03787239,0.031547792,-0.04109188,0.016515115,-0.028925907,0.019859504,0.067817554,-0.022404365,0.017356427,0.012936913,0.017329905,-4.8419832e-33,0.11943799,-0.07613394,0.07433934,-0.10382091,-0.036962476,0.04966392,-0.05236844,-0.027019233,0.007645063,-0.0029025273,0.09368211,0.027849955,-0.022763561,0.05898193,0.002664965,-0.04907038,-0.020425754,0.0809183,-0.009103793,0.03258606,-0.015678303,0.028857877,0.019304752,-0.013526815,0.043965455,-0.0026674,-0.00235239,0.047178917,0.043961715,0.03134677,0.004235008,0.008396496,-0.09514866,-0.035901275,0.02798913,0.039235543,0.007732994,0.05764946,-0.0020951896,0.030160794,0.0012582819,0.030039648,0.026454737,0.080843836,0.0315075,0.08069104,-0.08897448,-0.065255605,-0.02085263,-0.10957126,0.061651632,0.049975533,-0.044823587,0.050210007,0.051692717,0.034587983,0.023957308,-0.022385204,-0.017148465,-0.10408684,-0.07990176,-0.03334663,-0.039508242,0.020246433,0.016293773,0.054461043,-0.01980037,0.05879346,0.042720944,0.054022487,0.045106504,0.05235168,-0.008396321,0.0152705815,-0.03349119,0.0036006563,-0.0049580857,-0.042199552,-0.012630103,-0.028187508,-0.0010247728,0.028652018,-0.059734844,-0.08893792,-0.06838075,-0.11360461,-0.05805655,0.15880704,0.07354513,0.02004949,-0.046266824,0.055798803,-0.026387112,0.07558588,0.0018859664,-4.5626727e-08,-0.0300599,-0.053719696,-0.0067263907,-0.029969394,0.012937233,0.00522269,0.024086235,-0.007432874,0.09543356,0.015463371,-0.031060848,0.102133274,-0.028585287,0.02390337,-0.027266705,-0.0145243425,0.032137424,0.04652131,0.066919476,0.047877282,-0.07969061,0.02973674,-0.03262647,-0.0135880485,0.03740004,-0.07672664,0.053578578,-0.018912755,0.0442255,0.0059740874,0.025476916,0.05225882,-0.02590368,0.0062189945,-0.052678246,-0.00058071007,-0.036315527,0.010494948,-0.048129506,-0.07313764,-0.0068277153,-0.012151751,-0.07828274,0.012850605,0.063541904,-0.008559256,0.07033619,0.0051976447,0.004024477,0.011924989,-0.045223936,-0.00059279404,0.022495827,-0.09892551,-0.09333184,0.006804821,0.06561869,-0.06882558,-0.04275591,-0.075680755,0.024309484,-0.030445458,0.17502312,0.018915905 +1.14.99.53,"The enzyme cleaves chitin in an oxidative manner, releasing fragments of chitin with an N-acetylamino-D-glucono-1,5-lactone at the reducing end. The initially formed lactone at the reducing end of the shortened chitin chain quickly hydrolyses spontaneously to the aldonic acid. In vitro ascorbate can serve as reducing agent. The enzyme contains copper at the active site.",384,1.0,-0.08264028,-0.045315098,0.05586646,0.052880805,0.059935004,0.042546235,-0.0372037,0.044360608,-0.056339182,0.056055278,0.098175354,0.026467832,-0.01823641,-0.014028052,-0.12625791,0.029302275,-0.048189107,0.0133102825,-0.04628522,-0.01648318,0.07988934,-0.034351617,0.07169437,0.056561116,0.055400703,0.0097668925,0.023286553,-0.008464854,0.017428191,-0.055869237,0.018686198,-0.06820036,-0.0376587,0.059222497,-0.073337786,0.07795043,0.008215558,0.0099306945,0.09571452,0.02962744,0.025087865,-0.068923466,-0.05449733,0.011135976,0.06609216,-0.08338097,-0.034312855,0.0048330952,0.042152613,0.021184916,-0.034237973,0.027180916,0.011995414,0.020243397,-0.030548282,0.0463891,-0.03831316,-0.12475378,0.026537595,0.10608374,0.07426154,-0.0017942383,-0.09389512,-0.03782735,-0.014594528,-0.026953796,-0.01369023,-0.04222763,0.05030639,-0.029707585,0.05271261,-0.022833768,-0.110435754,-0.0069524073,0.022966076,0.015900362,-0.028679322,-0.09321674,-0.048481464,0.0057338453,0.03325866,0.003385472,0.034543514,0.097359754,0.016150808,-0.010758441,0.024828846,-0.018059216,0.0075377803,0.032137,-0.029110353,0.022202019,-0.026516665,-0.013530556,-0.03675397,-0.044775788,0.055721804,-0.015428965,0.030609204,0.02620271,0.046222456,0.017722508,-0.031811368,-0.06390839,0.032246087,0.009781972,0.039224595,0.0001316441,0.052788828,-0.04658435,-0.00810645,0.043495703,-0.045145877,0.014925908,-0.04514104,0.16475627,-0.0025404654,-0.015159505,0.0049704304,0.0013403748,0.012299223,0.046592373,-0.044720076,0.106406905,-0.034286298,-0.017282493,-0.0363478,3.15508e-33,0.015208949,-0.0050740223,0.016221449,-0.030008228,0.009260797,0.034176692,-0.1045732,-0.03004227,0.0074022226,-0.052024025,-0.04475496,-0.022739502,-0.035238843,0.07436651,-0.009629155,-0.07894664,0.03871309,-0.011703181,0.07016615,-0.029403308,-0.02536855,0.07458081,-0.07256672,0.0650559,0.063896544,-0.022752844,-0.032414816,0.07050158,0.048272792,0.006618008,0.007672102,0.05138935,-0.02306217,-0.041884482,0.002523026,0.0268325,-0.035954,0.02514741,0.01723103,0.09884842,0.05036914,0.050041962,-0.05833576,-0.03121451,0.011904276,-0.08996379,0.0027875185,0.052696306,0.006204738,0.02779299,0.06261641,-0.060709797,0.06328619,0.058290664,-0.017318618,0.0072820904,-0.02977244,-0.030021584,0.09602112,0.027787527,0.061660606,-0.032176506,-0.029071115,0.010825037,0.0013735009,-0.030230645,-0.0054898537,-0.035193026,-0.06703992,-0.018143065,-0.10953541,0.037186723,-0.0028773902,-0.039156772,0.02056506,-0.0074830647,-0.1251483,0.012616418,-0.007078038,0.016376363,0.044390302,0.050191656,-0.032204643,0.020800032,-0.025291825,0.04892107,-0.0018293293,-0.06035051,0.034832824,-0.074860774,-0.013038837,-0.05413073,-0.036025442,-0.030115565,0.028069453,-3.2354997e-33,0.10987635,-0.09057641,0.06327025,0.023973271,-0.034276433,0.033228915,0.030446129,0.0067927856,-0.03852788,-0.017976854,0.046757128,-0.023007061,0.06507944,-0.033107325,0.0200891,-0.014789259,-0.03156274,0.093002126,-0.009278706,0.05609211,-0.068327025,0.06658378,0.05373682,-0.032386232,0.056509443,0.0033295443,-0.060191326,0.021412784,0.069746755,0.0034308124,-0.0830191,0.0017060769,-0.039796557,-0.052330222,-0.015710205,0.085383326,-0.041514974,0.0750762,0.021931373,0.0017031821,-0.0047218297,-0.032072145,0.042538363,0.039005354,0.019987732,0.05289761,-0.019322822,-0.09154442,-0.08304325,0.0151462145,0.082951,-0.02008744,-0.030172728,0.01175891,0.08008475,0.059794765,0.016862344,0.0015828363,0.010470393,-0.020187458,-0.036409877,0.038689457,0.050908905,-0.02512422,0.024414496,0.062169418,-0.045620363,0.12400154,-0.00076857867,-0.0898296,0.054009233,0.09436808,0.075947836,0.00859165,0.063435234,0.03384456,-0.13882615,-0.025482368,-0.07506619,-0.01748295,-0.012978365,-0.00992468,-0.058110505,-0.12195039,-0.09234686,-0.022543466,-0.0042152535,0.10969277,-0.059529316,0.05955048,-0.028139291,-0.0754267,0.0065195747,0.07410139,0.036056433,-3.357816e-08,-0.0036744687,-0.039816868,0.06560316,-0.031204998,0.0050786454,0.032700278,0.06608059,0.027218629,0.03189954,-0.06187656,-0.0016729579,0.118520916,0.024624115,0.035692073,-0.061117284,-0.00916805,0.0030230868,0.019496484,0.012773399,-0.016729807,-0.052027255,0.044286218,-0.027365461,-0.011098624,-0.035797942,-0.048059948,0.02188998,0.12408687,-0.1159955,-0.094288684,0.056078266,0.03676963,-0.008285066,-0.10508684,-0.015271954,0.02513807,-0.023070669,-0.0020200696,0.0653473,-0.019857531,-0.023740556,-0.015573116,-0.06500213,-0.0042093154,0.0336272,-0.051476806,0.0055779642,0.0658504,0.046934348,0.037199598,-0.0083163865,0.005348665,-0.06245625,-0.10156477,-0.04883314,0.03045682,0.053229492,-0.074671976,-0.024731407,-0.10506232,-0.07426421,-0.093758985,0.10026121,0.028382914 +1.21.99.5,"This enzyme allows the common pollutant tetrachloroethene to support bacterial growth and is responsible for disposal of a number of chlorinated hydrocarbons. The reaction occurs in the reverse direction. The enzyme also reduces trichloroethene to dichloroethene. Although the physiological reductant is unknown, the supply of reductant in some organisms involves menaquinol, which is reduced by molecular hydrogen via the action of EC 1.12.5.1, hydrogen:quinone oxidoreductase. The enzyme contains a corrinoid and two iron-sulfur clusters. Methyl viologen can act as electron donor in vitro.",384,1.0,-0.030592639,0.055445623,-0.14046045,-0.04313801,0.09289877,0.029421851,-0.014890842,0.0854805,0.004060969,-0.036625862,0.0055793575,-0.115580596,-0.040588196,-0.009352261,-0.07065842,0.02272887,-0.059964452,-0.0009941633,0.0048440234,-0.0698729,0.027959144,-0.015888209,-0.062185287,-0.069296114,-0.06849924,0.052163407,0.009375924,-0.033068426,-0.01810118,-0.040429663,0.02639661,-0.006512268,0.03012589,-0.05344927,-0.051456843,0.10987839,-0.062588654,-0.053986017,-0.013795575,0.08937298,-0.05180844,0.015599284,-0.03047494,0.005263475,0.0058579645,0.022800814,0.019988125,0.020747023,-0.010342013,-0.043199252,0.011655574,0.00455541,-0.05102539,0.07205556,-0.0073197405,0.024521858,-0.0016859365,-0.025555162,0.00014128632,-0.026002789,0.08160218,-0.036592517,-0.011309426,-0.05962906,0.00081222184,-0.013770026,0.009719887,-0.09411933,0.01651005,-0.09926901,-0.03135872,-0.0039565098,-0.04150457,-0.008495356,-0.024984676,0.030934382,0.037603542,-0.0013775267,0.027493415,0.0066705416,0.004915366,0.0051694363,0.024218949,0.0943526,0.077135995,-0.0006812673,-0.015418403,-0.058919616,0.010281367,0.084565945,-0.0015279152,0.018128483,0.0014148327,-0.04216293,-0.08253886,0.08637667,-0.032154545,0.013263331,0.010460419,-0.037536196,-0.025946153,0.023719955,-0.09185796,-0.10553402,-0.11588987,0.04767957,0.04136781,0.12509394,0.06764192,0.020913152,-0.031410713,0.0574395,0.031931672,-0.02675919,-0.02497104,0.14791705,0.066155806,-0.0714461,-0.069763534,0.03307509,0.039840166,0.0136490995,0.049586717,0.001149677,0.023057641,0.023365257,-0.060798544,4.0763448e-33,0.027674781,0.06732749,0.0032954582,0.019427905,-0.016970744,0.059994858,-0.09251965,0.024962334,0.020225054,-0.13743834,-0.017351395,-0.099382095,0.00763167,0.004082553,-0.08955252,-0.036116976,-0.018480714,-0.043307796,-0.010576185,-0.041612383,-0.022231333,0.056045607,-0.05168716,0.015199387,-0.015797304,0.029129658,0.0069025615,0.020635316,0.014560583,-0.017749289,-0.0077257357,-0.02995049,-0.07470224,0.04771346,0.05330097,0.06539989,-0.070882656,0.012726745,-0.012716068,0.07621383,0.009495921,0.059807777,-0.034421436,-0.0100989835,0.14161088,-0.06725046,-0.039286528,0.05337123,0.04459341,0.00049391726,-0.020452451,0.024759943,0.053477462,-0.04858535,-0.09027377,0.052903615,0.020335723,0.0040434757,0.0020289482,0.06314637,0.025671441,0.10037075,0.008792546,0.10347494,0.012841417,-0.020691223,-0.0078050336,-0.0819614,-0.024453837,0.034051213,-0.043395054,0.010784136,0.08396998,-0.008460332,0.020685676,-0.072636485,-0.02272035,-0.02166291,0.08483225,-0.07376134,0.0076317373,-0.042079315,0.071509786,-0.083508946,-0.044593368,-0.07916067,-0.030541226,-0.105839714,0.02929233,-0.014908031,0.076971546,-0.10354391,-0.058909692,-0.061988365,0.0140687125,-3.8428923e-33,-0.0026915702,-0.04404549,-0.026570588,-0.03766804,0.00820504,0.07985659,0.0023074835,-0.026606202,-0.012993065,0.022137966,0.08330941,-0.012871074,-0.01562872,-0.033543408,-0.009163625,0.014714408,0.058024377,0.05619715,-0.0048703444,-0.039496236,-0.02170307,0.061341897,0.051438093,-0.0005756276,-0.013782814,0.03215204,-0.049272366,0.057833605,0.11636353,0.023476899,-0.017059924,0.00796547,-0.053593818,-0.007967823,0.027757304,0.0757223,-0.044933375,0.0558699,0.06124202,0.0308872,-0.016750677,-0.06599131,0.001951662,-0.005528429,0.0076244487,0.09512663,-0.11028686,0.016576892,-0.010960567,-0.071458444,0.061288994,0.03133074,-0.034100283,0.020905176,0.038370293,0.036423516,0.049665213,-0.014692579,0.022180201,0.017706856,-0.031127293,-0.05462406,0.042255796,0.020631466,0.003221042,0.029638963,0.04205835,0.13230109,0.067556836,0.02117411,0.0455977,0.055195205,0.06988598,-0.028579988,-0.07733996,-0.08850069,0.01096455,-0.019693974,-0.026515642,-0.061305523,0.007512496,-0.0074991984,0.01604029,-0.11396037,-0.0058490913,-0.109984465,0.004809484,0.07774561,-0.049077928,0.055792943,-0.066982105,0.01641355,-0.06118949,0.04249324,0.08665948,-3.9919858e-08,0.029180206,-0.07199329,0.031068094,-0.01015854,0.03082484,0.00050996494,0.006296804,0.042072464,0.05031866,0.011894895,-0.08553378,0.062059753,0.07499947,0.014779313,0.06285067,0.06389557,-0.015365935,0.0023123394,-0.019470155,0.0206014,-0.033205975,0.0012214358,-0.1256721,-0.0012478065,0.02715797,-0.036494587,0.08796124,0.048409414,-0.012547343,-0.01566393,0.01703119,0.06867136,-0.016887577,0.012090485,-0.07434745,0.026133636,-0.01843171,0.021245096,-0.017246975,-0.020521207,-0.015177868,0.031172808,-0.08589524,0.06587753,0.046005543,-0.02269492,0.0011765996,0.008846079,0.03577376,-0.005505617,0.029286547,-0.008885439,0.06008333,-0.021800907,-0.11000743,0.06437855,0.0010721561,-0.028355205,0.029193832,-0.079116605,-0.016663296,-0.03590412,0.14504555,0.019758377 +2.1.1.337,"The enzyme from opium poppy (Papaver somniferum) can also methylate (R)-reticuline, tetrahydropapaverine, (S)-glaucine and (S)-bulbocapnine. It is involved in the biosynthesis of the quaternary benzylisoquinoline alkaloid magnoflorine.",384,1.0,0.036633994,-0.060489178,-0.14008038,-0.022190543,0.051381275,0.12381775,-0.08722135,0.04092929,0.015962394,-0.05138946,0.012637053,0.03805531,0.0032894854,0.046312552,-0.010802982,0.0074674836,-0.07566554,0.010154717,0.02889418,-0.04222433,0.07352577,-0.012888093,0.02584599,0.007182844,-0.029303651,0.08987349,-0.015226096,-0.009727061,0.019792007,-0.05886833,0.06747561,0.09137291,-0.0786975,-0.08489742,-0.04559141,0.06072514,-0.06901296,0.017709134,0.11132963,0.02749342,0.05144735,-0.034109857,-0.044418883,0.009277165,0.02318337,0.007005492,0.043822974,0.04268788,-0.020474076,-0.019516386,-0.0009915521,-0.03487135,-0.05895045,0.10837107,0.025583602,-0.019859709,0.00953295,0.030016873,-0.022471871,0.06182531,-0.016867444,0.059598316,0.0045935656,-0.0033095628,0.044181522,-0.024003997,-0.044802126,-0.01040176,0.09040478,-0.07848173,0.003949824,-0.06306815,0.013196254,0.04960827,-0.065037936,0.06450433,-0.025518661,0.031469233,-0.0065946737,0.019248562,0.114274845,0.009911752,-0.024533207,0.10912156,0.0418953,-0.017769247,-0.034654766,0.068653665,0.08472212,0.0036935566,0.083419494,0.01058343,-0.070087686,0.021095108,-0.07656411,-0.035975147,0.014093865,-0.009943214,-0.072899535,-0.03325888,0.018365495,-0.012156437,-0.101287305,-0.053192005,-0.04219442,-0.0012227152,-0.023702513,0.017302467,-0.0044303345,0.026555294,-0.03064251,-0.035945993,-0.0024076863,-0.021367978,-0.060603525,0.03764192,0.04279759,-0.08214296,-0.05158035,-0.04631676,-0.036860123,0.017429378,0.034653,0.03613029,0.030983178,-0.026882248,-0.15561542,4.3785938e-33,0.03665253,0.094870426,-0.004328723,-0.03092551,0.029846527,-0.023067476,0.016938534,0.021106498,0.06392511,-0.08247872,-0.07503743,-0.00956132,-0.026518809,-0.025445595,-0.0072990973,-0.035216175,-0.045603767,-0.012499257,-0.0039321664,-0.09478585,-0.062341608,0.07918064,-0.10444969,0.0039815595,0.01625882,0.075040266,-0.017847804,-0.032022372,0.059839938,-0.01563742,0.032125026,-0.024014149,-0.089120604,0.001542509,0.07738915,-0.004635899,-0.05206019,-0.04737899,-0.051765244,0.030781342,-0.004005643,0.016928863,0.06276707,0.052143686,-0.012038198,-0.060010154,-0.10703603,0.044046212,0.07516478,-0.008887977,0.058682553,-0.0022174215,-0.00611652,-0.021894885,-0.0801223,0.041621935,-0.05151944,0.013862026,-0.0025512706,0.020156186,-0.0113116605,-0.035589986,-0.014909265,0.0016904187,0.07345731,-0.037374344,-0.058544103,-0.02086199,-0.0029828043,0.09028629,-0.04608167,0.0055279434,0.073871315,0.011109605,0.026144283,0.0010238584,0.005063221,0.024307156,0.06953566,-0.057637088,0.041264758,-0.064201355,0.015306349,-0.016231863,-0.07235309,0.017608097,0.07522673,-0.014517242,-0.01438612,0.028060123,0.007270615,-0.013308524,-0.019984325,-0.038066093,-0.029282702,-3.9652345e-33,0.017760519,-0.080358684,0.047060642,-0.0069809244,0.020648623,0.07555953,-0.016464269,0.02969287,0.014108893,0.04663567,0.021320736,-0.030299325,0.081796415,-0.010998046,-0.040842053,-0.00076348765,0.01743987,0.099172324,0.009443053,-0.021401025,-0.070543304,0.09164326,-0.046114117,0.05582534,-0.03006276,0.046557944,0.055588238,-0.0114226565,0.077165864,0.07942797,0.054749504,-0.04111236,-0.07783176,-0.04112476,-0.017084053,0.09372627,0.04601189,0.007055548,-0.06971168,0.021254405,-0.01188938,-0.019958114,0.049416456,0.0352554,0.00028348828,-0.038798694,-0.098200455,0.059355218,0.06331886,-0.036138885,0.036812503,-0.019365873,-0.046271384,0.01417507,0.00080745923,-0.05132769,0.0077105984,-0.09056446,-0.03181953,-0.06691121,0.0011585341,-0.01758138,-0.06707782,-0.11822201,0.07518864,0.010108663,-0.00087404845,0.02781727,0.07400974,0.010125738,0.11569684,0.014376034,0.0512139,0.061185535,-0.011119226,-0.060253043,-0.051835354,-0.026294397,0.018765606,-0.038798083,0.09473209,0.01805049,0.012439907,-0.0057432232,-0.0092485305,-0.032131974,0.030577125,0.1502861,0.023159886,-0.027157392,0.022077415,0.007849766,-0.05242723,0.081432275,0.070636496,-3.9465366e-08,0.018164154,-0.05811321,0.009631666,0.015151067,-0.04363148,0.02689571,0.017808111,-0.0664686,0.039186865,-0.07239844,-0.004649982,0.029299814,-0.019169973,0.03228044,0.03401467,-0.03782867,-0.027803252,0.079812676,-0.016769638,0.00995213,-0.0808313,0.02913294,-0.056273628,-0.080980115,0.042775817,0.037709102,0.01239531,0.03916183,0.018072637,0.05403038,0.045219757,-0.02890285,0.034421965,-0.04003449,-0.09740857,0.039781637,0.04116911,-0.033271566,0.009152085,-0.0034205858,0.02017886,-0.06666475,-0.06127047,0.083558954,-0.009497711,-0.08437898,0.011067735,-0.009160009,-0.005865984,-0.031798083,0.00935774,0.024733795,0.011864379,-0.100461274,-0.07813165,-0.055082608,-0.045244522,-0.013409017,0.015123545,-0.13070108,0.017303802,-0.009220059,0.2132987,0.05969044 +2.1.1.338,Found in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol.,384,1.0,0.020734599,0.0037279301,-0.0804595,-0.013226546,0.07819947,-0.0013499678,-0.014765822,0.03021413,0.03497278,-0.0019972958,0.10249353,-0.044448487,-0.060991757,-0.012178277,-0.053955052,0.14088771,0.021031728,-0.0038408593,0.04031071,-0.016054548,0.06667558,0.020774601,0.023972899,0.021936597,-0.03921543,0.010971554,-0.03329735,-0.0145255355,0.022436935,-0.09277894,-0.029571319,0.079672776,0.07488943,-0.00796994,0.02498176,0.076212175,-0.002038964,-0.010993868,0.08874899,-0.0022699176,0.10118603,-0.03797649,0.011508945,-0.089053884,-0.098019265,0.002379403,-0.044985604,-0.015120683,-0.0061542257,0.09106227,-0.03756219,-0.08706509,-0.029353084,0.04526914,0.006306273,-0.025972,-0.008779637,-0.022354266,-0.019772245,0.018283047,0.034009796,0.03843145,-0.011918208,-0.019972634,0.01313741,-0.012840553,-0.051887628,-0.04203984,0.0704812,-0.066105515,-0.0022828623,-0.09403277,-0.050203487,0.060628504,-0.048416052,0.059697866,0.06060581,-0.02746505,0.06136376,-0.010120991,-0.03286638,0.123585306,0.03522085,-0.01234626,0.03426929,0.07883496,-0.016853096,0.05042397,-0.010414949,-0.02901226,0.0011275634,0.035563666,-0.073685884,-0.068080366,0.06339292,-0.0012807739,0.05028975,-0.0025615199,-0.0021816627,-0.040571757,0.058140974,-0.014910839,0.00932578,-0.10935451,-0.09700026,-0.019601699,0.0041855816,0.009112142,0.026859198,-0.03633027,-0.067105845,-0.022545509,0.046659265,-0.0043307813,-0.029438673,0.055451207,0.014327115,0.0082182195,-0.08198376,-0.006567901,0.0062593645,-0.029915309,0.060685266,-0.019453587,-0.004712805,-0.042466927,-0.13128093,-2.1861697e-34,0.045030747,0.019229813,-0.0057268897,-0.050848886,0.03936215,0.01816435,0.015430788,0.053565927,-0.022482015,-0.0099893445,-0.09321821,-0.088971265,0.008970918,0.004272367,-0.0581005,-0.04330243,0.007693237,-0.051004656,0.032593705,-0.08647801,0.027324215,0.022693876,-0.021001447,-0.059028268,-0.052196354,0.044417582,0.010567033,-0.07744613,0.072991654,0.007565686,0.05427367,-0.09288131,-0.03987894,0.053497903,0.0015745423,0.09379831,-0.04294598,-0.06665766,-0.03051315,0.0763835,-0.011102012,-0.03208695,0.048115194,-0.01788512,-0.0030397628,-0.067330346,-0.087398276,-0.045070097,0.07711618,0.0008979057,0.0471187,0.015313541,0.11524233,-0.04537675,-0.009434129,-0.01316473,-0.017161991,-0.011673585,-0.079574876,0.0537661,-0.026535058,0.046525393,-0.036427815,-0.014790879,0.035110883,0.005225614,-0.09139776,-0.0016842305,-0.03457005,0.058599386,0.011063944,-0.060861096,0.109844774,-0.01593047,0.036413934,-0.044300403,-0.041564226,0.04974941,0.031307444,-0.012574142,-0.0010637622,-0.03359504,0.0167542,0.015188591,-0.11447308,0.009234872,0.0035970565,-0.008323921,-0.02073428,0.076033615,-0.029584546,-0.042033665,-0.09768407,0.040172454,-0.03457977,-7.121498e-34,0.033518825,-0.029060554,0.07297326,0.0014603927,-0.030732447,0.07273682,0.049048208,0.012283908,-0.013505255,-0.0061791046,0.03556454,0.037941553,0.05284694,-0.006087937,0.13379748,0.14565703,-0.011705399,0.060890414,0.030743605,-0.037349932,-0.06127933,0.06555925,-0.008652721,0.03954196,0.080596834,0.014017005,0.07717098,-0.008944788,0.1005208,-0.030534782,-0.077512726,0.0029648945,-0.016538389,-0.08119307,0.0282185,-0.010878061,-0.032614548,-0.023919273,-0.086137064,-0.0038814596,-0.04656191,-0.02388784,0.06158617,0.08189629,0.0629989,0.069347516,-0.05595916,-0.011221343,-0.040970873,0.044137612,0.08154036,0.010330413,-0.027281858,0.043034665,0.027798565,0.03908063,-0.052969567,0.074223556,-0.03745792,-0.0733388,-0.06680472,-0.033270884,-0.019627135,0.023088334,0.08531332,0.042866945,-0.008963133,0.0059711877,-0.024270106,-0.021678628,0.13147771,0.018619755,-0.023432828,-0.00052345864,-0.031143505,0.030823568,-0.00080893526,-0.020391848,0.017848749,-0.05053028,0.041256927,0.02885146,0.050237782,-0.05181755,0.00079063454,0.0033031933,0.030404804,0.13396592,0.019146686,-0.03886018,-0.017784312,0.01104052,-0.1376971,0.0099606775,0.10775217,-2.3303093e-08,-0.013238148,-0.08424681,0.002200073,-0.018874057,0.0029046205,0.07171485,0.05083129,0.027123677,0.010500645,0.030368006,-0.037471198,0.00545503,0.039684385,0.013198679,0.022891084,-0.08018704,0.007782009,0.059549335,-0.018968498,-0.011564596,-0.12576921,0.04389691,-0.019206164,-0.0017893709,-0.07944359,-0.095098525,0.033237386,0.007159703,0.02475128,0.00035619372,-0.03397121,0.07882969,0.0210868,-0.07064622,-0.039807107,0.09043078,-0.038472828,-0.05443275,-0.03092793,0.02264717,-0.0042392747,-0.01402399,0.04698518,-0.027481899,-0.028876323,-0.054926123,0.02866717,0.030479902,0.008877746,-0.017070707,-0.013717363,0.0316597,0.0110994745,-0.0783867,-0.0862325,-0.0044818204,0.0018535525,-0.08881406,-1.4146789e-05,-0.039031137,0.0015399138,-0.04429773,0.18778108,-0.002811593 +2.1.1.339,"The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.",384,1.0,-0.009169524,-0.061423983,-0.061878502,0.0016896614,0.040022098,0.022330483,-0.04953975,0.06608965,0.050692104,0.012503445,0.054899115,-0.0019924361,-0.091828555,0.004337295,-0.023618512,0.058100507,-0.0049301507,0.054347,0.03161628,-0.024079366,0.06562027,-0.069468066,-0.013482617,0.017638467,-0.021694295,-0.043110196,-0.027072318,-0.011336464,0.0015153721,-0.097126365,0.0004628832,0.06572885,0.08180611,0.0035043575,-0.03302395,0.062190216,0.0059990594,-0.03164647,0.041640937,-0.06473127,0.11702696,-0.053717136,-0.028671619,-0.027034678,-0.011809727,-0.109032325,-0.023732131,0.0038103336,0.04181156,0.09891468,-0.024939053,-0.0077973795,0.012067222,0.074160494,-0.042578883,-0.019847894,0.06261481,0.009422457,0.027710102,0.008504665,0.0116217295,-0.016695105,-0.009944314,-0.039490055,0.00033472356,-0.039742548,-0.08991805,0.013186092,0.040185783,-0.019870728,-0.008970765,-0.06877069,-0.08027643,0.071011595,0.02743582,0.10122051,-0.018125061,-0.012289718,-0.03029997,0.05728434,0.010653731,0.098749645,0.024155412,0.026183262,0.05524474,0.08554605,-0.0092988545,0.04079405,-0.003567596,-0.022205567,-0.022948552,0.018862737,-0.07029057,-0.045727387,0.04097856,0.03656094,-0.019381987,-0.05842949,0.021480065,-0.029019818,0.08795235,-0.008015993,-0.03765051,-0.14376579,-0.107083365,0.030318791,0.033448398,-0.0037185117,0.0063298843,-0.005448672,-0.015778666,0.005330108,0.029929955,-0.0045851055,-0.015114404,0.07823683,0.040201526,-0.020887587,-0.07221517,-0.01900786,0.003795501,0.0007351553,0.07393865,-0.02402022,-0.0075748106,-0.054126717,-0.060216323,5.2806064e-33,0.05092379,-0.018230204,-0.054763705,0.021756995,0.018638905,0.040487263,-0.02857907,0.03387674,-0.036846977,-0.024853617,-0.17935006,-0.018720936,-0.0036152476,0.035384983,-0.024942735,-0.027830917,0.0095590865,-0.036910117,0.100000344,-0.04909648,0.0058577014,-0.060380906,-0.024079101,-0.038209286,0.06592454,0.028599972,-0.02156419,-0.020623295,0.03218997,-0.013864536,0.046690535,-0.088732004,0.0017383441,-0.008012483,0.02584055,0.06940531,-0.064646475,0.0029856907,-0.018751075,0.050825004,0.030773185,0.043601,0.101423934,-0.045791987,0.034365337,-0.030692508,-0.03331764,-0.018031444,-0.003157372,0.07993579,0.039854094,0.013745084,0.1325097,-0.070396125,0.012105447,0.009076072,-0.025723381,-0.034688294,-0.025236255,0.061918404,-0.046504296,0.06302742,-0.04966021,-0.0041725775,0.020221222,0.09562295,-0.05998027,0.061030596,-0.01871862,0.095509626,-0.034058515,-0.03504724,-0.0027845816,0.0038556329,0.004068693,-0.06041604,-0.011713073,0.046294514,0.061887886,0.046524737,-0.014414911,0.0001669226,-0.11380369,0.03304892,-0.12392509,-0.042872205,-0.049296655,0.030461377,-0.0071211318,0.03091145,0.024178965,0.007074975,-0.06128064,0.060400426,-0.011651306,-5.1513645e-33,0.049624644,-0.08578561,0.10243672,-0.030460639,-0.04914246,0.07702933,0.07752508,-0.05294901,0.006217247,0.018258004,0.0018219639,0.05482429,0.04595316,-0.009115353,0.03337309,0.096307494,-0.069475934,0.04422043,0.055970393,-0.04056369,-0.08295754,0.15684594,0.02451087,0.0073084,0.080041565,-0.029911883,0.08043021,0.059853267,0.088713825,0.014203416,-0.038609285,-0.042172585,-0.008370029,-0.051442917,0.040902715,0.013780876,0.0062500145,0.004677485,-0.008983347,-0.035792287,0.023135418,0.0042038793,-0.055342767,0.003160085,0.032610897,0.020996565,-0.10134557,0.0045563113,-0.021151343,0.017520562,0.07629729,-0.028749622,-0.05414034,0.0129893785,0.071961604,-0.02594017,-0.014053552,0.027094122,-0.0690459,-0.10371231,-0.11947998,-0.022291837,-0.022370236,-0.0032060856,0.05335436,0.075617485,-0.01172067,0.051911194,-0.10329085,-0.03669226,0.11892134,0.0030130632,0.019699195,0.020470314,-0.023990404,0.0038119361,-0.016165849,0.024055641,0.025302075,0.022062892,0.017896252,0.012057623,-0.046018366,-0.060032886,0.025016246,0.040577665,-0.02096639,0.031172281,0.043786522,0.035708796,-0.0021758548,-0.034134433,-0.09767158,0.005525774,0.039873566,-3.8464886e-08,0.0028152207,-0.045531448,0.062661625,-0.025284715,-0.044884,0.06547923,0.034045376,0.040958002,-0.047105346,0.04491357,-0.035037816,0.061647378,0.023624774,0.016940534,0.07208535,-0.013924282,-0.004723227,0.064940706,-0.0067049437,-0.0064463574,-0.04730654,0.0594779,-0.081161946,0.067355506,-0.028629724,-0.10693255,0.013298609,-0.08285637,0.026737224,-0.038739517,0.024700923,0.023907067,-0.019896746,-0.059465487,-0.085773446,0.032978002,-0.08113093,-0.035629038,-0.010949311,0.047434725,-0.038210683,0.01062098,0.007511362,-0.093497016,-0.08420959,-0.05202622,0.024938956,0.056121815,-0.03270014,0.056666303,0.008540342,-0.020314362,0.035246015,-0.07439428,-0.070681825,-0.0145920515,0.012526094,-0.098215505,0.0030565427,-0.045432895,0.015602482,0.009658599,0.20716718,-0.013452066 +2.3.1.261,"The enzyme is part of the biosynthetic pathway of phenolphthiocerol, a lipid that serves as a virulence factor of pathogenic mycobacteria. It catalyses the elongation of 4-hydroxybenzoate that is loaded on its acyl-carrier domain to form (4-hydroxyphenyl)alkanoate intermediates. The enzyme adds either 8 or 9 malonyl-CoA units, resulting in formation of 17-(4-hydroxyphenyl)heptadecanoate or 19-(4-hydroxyphenyl)nonadecanoate, respectively. As the enzyme lacks a thioesterase domain [1], the product remains loaded on the acyl-carrier domain at the end of catalysis, and has to be hydrolysed by an as-yet unknown mechanism.",384,1.0,-0.04202396,-0.045009438,-0.09307497,-0.02032612,-0.01722033,0.0058222753,-0.02689339,0.08628962,-0.0015713212,-0.03345097,-0.014363007,-0.116483025,0.00062344025,0.055184837,-0.07608649,0.066337824,-0.003290933,0.034636393,-0.04272215,-0.0029545694,0.064681746,0.08604465,0.032828268,-0.038738664,0.041246563,0.016738452,0.08038487,-0.018599931,-0.024067603,-0.06619554,0.015029801,-0.059723206,0.04204315,-0.05463805,0.09852915,0.09148394,-0.010491336,-0.074106954,0.08561021,0.0038586003,0.08625857,-0.072590955,0.00861645,-0.007177628,-0.014470335,-0.014822181,-0.023212826,0.050754227,0.046701908,-0.058323596,-0.08775324,-0.026272817,-0.031115448,0.069722205,-0.08636556,-0.0023040962,0.04049046,-0.01893402,-0.011363477,0.056622498,0.054115634,-0.0025835051,0.00157857,0.059318367,-0.06111841,-0.07154535,-0.027717471,-0.002810052,0.014364978,-0.004670197,-0.04689668,-0.0125426985,-0.029885339,0.047065385,0.02760056,-0.02173593,0.05976222,-0.037608095,0.020636592,0.011746455,-0.039094344,-0.016228955,0.061299887,0.043747656,0.035994075,-0.028039379,0.11690865,-0.025266506,0.056688618,0.1263575,0.03322871,-0.027225593,0.039781187,-0.032881152,-0.052234683,-0.0015686345,0.14917462,-0.004342145,0.025901195,-0.0043839146,0.017109307,-0.040975705,-0.022681424,-0.05789201,-0.03845004,0.026300292,-0.0015098978,0.09377079,0.043947082,0.01979115,-0.043250777,-0.015714789,0.028264318,-0.025290418,0.027052604,0.10046585,-0.0014121629,-0.045991454,-0.05813955,0.03638371,-0.02188926,-0.08786261,0.04795425,0.021360723,-0.09403848,0.019809466,-0.09135902,4.1432286e-33,0.06382415,0.023837589,-0.0012118332,-0.0017397763,0.009626884,-0.027919319,-0.14173055,-0.00063223834,-0.11200322,-0.046593707,-0.0075305603,-0.09196231,-0.0037259422,0.056387074,-0.059373826,0.007096437,-0.07419523,0.02778341,0.08575974,0.071719736,-0.0014567345,-0.0121319555,-0.024059126,0.010156139,-0.024343189,0.044931147,-0.021051217,0.06124868,-0.026989462,0.030605169,-0.048965592,-0.038112894,-0.06519267,-0.04434031,0.019318908,-0.0007094328,-0.054897286,-0.08614394,0.020921139,0.010620028,0.034739442,-0.01258943,-0.036124274,-0.04000965,0.08946329,-0.033752147,-0.00906186,0.08567757,-0.01804708,0.03708496,0.027842969,-0.0324719,0.107302584,0.000325938,-0.060557097,-0.0318255,-0.0466497,-0.005877945,0.052968062,-0.031021165,0.057027146,0.095756605,-0.055856857,0.10062688,-0.061524328,-0.06319858,0.035302207,-0.0010665839,-0.002420842,0.03121667,-0.037843194,-0.019131484,0.027748607,0.010102583,0.09064456,-0.088620014,-0.026195923,-0.033008873,0.06039382,-0.003356134,0.06944651,0.02175896,-0.0010985156,-0.060994256,-0.023561815,0.015367468,-0.045554727,-0.0144649865,-0.06548264,0.024305403,0.034665696,-0.11881712,0.0075316555,0.05826985,-0.022774113,-6.262095e-33,0.09402823,-0.12359566,0.031667944,-0.0773175,-0.041942786,-0.030184137,0.067088045,0.04565942,0.07093113,-0.042111386,0.06879382,-0.032367047,0.010829558,-0.030379582,0.011906093,0.04162326,0.0353172,-0.03062345,-0.03727177,-0.08603898,0.034927353,-0.011203925,-0.023436045,0.035948392,-0.0014310044,-0.008309564,-0.04994787,0.059093677,-0.0050966847,0.11232587,-0.0033673018,-0.022061389,-0.0076438617,-0.03828767,-0.057485264,0.033231635,-0.11323149,-0.025649305,0.07641892,-0.005117772,0.021562964,0.014305328,-0.013959162,-0.011194432,0.0004244786,0.067959435,-0.089057304,0.040382307,0.048911646,-0.08580028,-0.03171716,0.04588953,-0.01956132,0.055153675,-0.0069956966,0.07324705,0.014385614,-0.0435955,0.011911368,-0.060194694,-0.06252136,-0.04103013,0.04561544,0.010150431,0.04707133,0.08732257,0.008538793,0.09491162,0.05394055,-0.039784867,0.0532481,0.017594855,-0.024599915,-0.008386601,-0.04044509,-0.03623899,0.0058784573,-0.0066393013,-0.04970947,-0.03586343,0.038653884,-0.026322367,0.01872572,-0.17408347,-0.02470855,-0.08554123,0.05410287,0.10155986,-0.019149777,0.08841808,0.049625427,0.08360592,-0.027556825,-0.0055847974,0.073156945,-4.970205e-08,0.015405667,-0.07937822,0.061792854,-0.02228371,0.030891858,0.046278365,-0.026364436,-0.03774926,0.07400491,-0.030863293,-0.0027272622,0.040810976,0.026820377,0.0039092447,0.039629567,-0.007895106,-0.071629204,-0.017605314,-0.023126498,-0.06323498,-0.08238975,-0.0066758892,-0.035030924,0.005015136,0.006067207,-0.02808851,0.030585418,0.04693705,0.007666876,-0.04506223,-0.029142534,0.068010904,-0.039261192,-0.0022215708,-0.070556976,0.043005325,-0.04895702,-0.095918834,-0.039373357,-1.211619e-05,0.0839749,-0.018158237,-0.024981156,0.018204276,0.03621865,0.050753273,-0.022188624,0.024254322,0.025323614,0.003226587,0.014090884,0.021632452,-0.044287164,-0.015643107,-0.0048845373,0.07233112,-0.030570487,-0.0058395155,-0.055093102,-0.052643094,0.028712356,0.0034287034,0.15178214,-0.07319719 +2.3.1.262,"The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl-3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone. The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl-CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone. However, when EC 3.1.2.32, 2-aminobenzoylacetyl-CoA thioesterase, is present, it removes the CoA moiety from the product, forming the stable (2-aminobenzoyl)acetate.",384,0.99999994,-0.082528025,-0.02795636,-0.04937694,-0.09437538,0.114002444,0.00851742,-0.06203246,0.06995242,0.037842307,-0.00082747004,0.022474328,-0.05060836,0.0138207935,0.08684092,-0.06284341,0.046887677,-0.019609168,-0.03128505,0.014036788,0.021172578,0.04595524,0.020442678,-0.07071294,0.039794207,0.079790175,0.06272329,0.05915356,0.026605334,-0.068166345,0.0024506005,-0.04737458,-0.06829763,0.03745099,-0.086228296,0.06734997,0.06296175,-0.026610339,0.0055800453,0.11381549,0.050768897,0.040293943,-0.036850113,-0.009617852,-0.015139892,-0.0067654676,0.022787763,0.08662269,0.032023422,0.0712593,-0.013928868,-0.062087394,-0.019303754,-0.03248716,0.075720556,-0.06252091,-0.04040154,-0.044150963,-0.007091903,-0.07901356,0.05130339,0.0027108665,0.004099243,-0.014062622,0.02206613,-0.042545363,-0.04641355,0.043259136,-0.0053886017,0.018203983,0.008997997,-0.056494847,0.02284115,-0.012304298,0.029710174,0.032257378,-0.029388446,-0.0051088026,-0.008740035,0.020284194,-0.038865596,-0.027194886,-0.04139164,-0.0050920583,0.11024585,0.03862382,-0.028442925,0.03487744,0.036377914,0.043040525,0.048803546,0.052645706,0.041668635,0.006627146,-0.04065946,-0.04682177,0.055244062,0.011564809,0.06305559,0.08076955,0.013149148,-0.023769584,0.03572254,-0.030498985,-0.07814933,-0.03339399,0.00206317,0.019208254,0.13639846,0.016261837,0.0056217946,-0.0257093,-0.025917685,0.016349908,-0.018807633,-0.041896425,0.11671533,0.016973814,-0.06988785,-0.05671905,0.031450298,0.014836472,-0.030823566,0.099134274,0.067563556,0.035794258,0.06992703,-0.06406961,1.5302586e-33,0.0071551334,0.071384825,0.015770407,0.022874106,0.004263569,0.0012714515,-0.06897409,0.030719118,-0.04560014,-0.022270722,-0.031510334,-0.043877997,0.052229274,-0.006111466,-0.048938047,0.00507691,-0.0053432477,-0.05465812,0.05128711,-0.013647479,0.036278725,0.015203213,-0.023538379,0.0149406,-0.026858043,0.027065586,0.05859668,0.081576295,0.00011593933,0.010854633,-0.07055942,-0.038139105,-0.053886537,-0.04313866,0.03129592,-0.03589301,-0.06205278,-0.03501309,-0.008028646,0.11453416,0.04298362,0.085121766,0.010054453,-0.07460917,0.04347727,-0.030902395,-0.014852171,0.15178584,-0.0038564103,-0.001964212,0.06972904,-0.036870286,0.07663033,-0.03534039,-0.047427062,-0.002983328,-0.04693115,-0.020214316,0.017531676,-0.021486681,0.045943324,0.07928057,-0.021973398,0.066901095,-0.041181233,0.01114321,-0.020646606,-0.086526655,0.007469853,0.056727763,-0.04973206,-0.028141938,0.07107515,0.04018683,0.03272496,-0.07781314,-0.10066798,-0.019355286,0.06401896,0.02880281,0.0044148723,-0.06644921,0.044314824,-0.0007176917,-0.04982676,-0.00054115924,0.069326825,-0.051686157,-0.0030508102,0.09691553,0.024135932,-0.13116379,-0.0055736057,0.02693473,0.0031890818,-9.391628e-34,0.10743395,-0.084430724,0.001392635,-0.07560068,-0.081046574,0.06787723,0.006449489,0.033539075,0.052666236,0.009182818,0.09099922,-0.01575087,0.027309706,-0.008106332,0.0072774966,-0.037258685,0.047487162,-0.024802517,-0.0026058066,-0.016545694,0.06734856,-0.01971933,-0.018066354,0.009869062,0.0360788,0.0066692,-0.03744224,0.11249533,0.03848137,0.09009527,-0.0542089,0.004383274,-0.0069542625,-0.0071343514,-0.020247865,0.10008118,-0.074804164,-0.0004109071,0.048622493,-0.00012531027,-0.009665887,-0.028006772,0.0020276955,0.04532012,-0.03548711,0.045909148,-0.03219375,0.01993735,0.0021467807,-0.10979972,-0.018160801,-0.0028828708,-0.050166685,-0.0014088652,0.017418405,0.07797119,-0.07372571,0.005363555,0.038136516,-0.07342316,-0.05221646,-0.08330406,-0.031766757,-0.08470854,0.050599117,0.06377425,-0.063891605,0.08531068,0.057724662,0.033697296,0.03527785,-0.0015454679,0.044864755,-0.015122459,-0.042653117,-0.009511345,-0.06267883,-0.0548391,-0.041491326,-0.014937295,0.014553424,-0.039010935,-0.037384972,-0.057948004,-0.10365215,-0.06574719,0.03779217,0.15868974,-0.05625598,0.004510286,0.0323982,0.015651867,0.010294055,0.088515155,0.041783165,-4.3849802e-08,0.024638368,-0.048366778,0.029040318,0.030952742,-0.03882273,0.030318417,-0.023655603,0.00021010426,0.03287124,-0.04038302,-0.017839523,0.068102986,0.048214447,0.054427385,-0.039016027,0.011454547,-0.051167767,-0.02080525,-0.03174319,-0.029777326,-0.066816024,-0.015466151,-0.106501125,-0.061586373,-0.02880048,-0.0723506,0.045101672,-6.7508604e-06,-0.03684406,-0.023312937,-0.06007902,0.0022024168,0.0028594225,0.0387685,-0.074037805,0.005896655,-0.105239764,-0.0025262018,0.023518112,-0.05217542,0.10628701,-0.017333632,-0.17011993,0.062134296,0.08435489,-0.034914125,-0.016764043,-0.002015817,-0.027374718,-0.091269374,0.08227182,0.016669217,0.017633494,-0.042582404,0.0073470646,0.022092042,-0.018853309,-0.055781405,-0.0417678,-0.048783805,0.005323821,-0.018415377,0.13837674,-0.003336202 +2.3.1.263,"A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the bacterium Clostridium sticklandii, is part of a degradation pathway of ornithine. It is specific for acetyl-CoA and D-alanine.",384,1.0,-0.058412913,-0.041910097,-0.03780015,-0.07381102,0.102087244,-0.0028133288,-0.064909525,-0.007959361,0.05320406,0.0325166,-0.018840246,0.00898271,-0.05564237,0.09511546,-0.048188146,0.05582505,-0.107244544,-0.00011809739,0.04270076,0.0021450862,0.10616691,0.075735435,0.023705805,0.01969206,0.03332452,0.07121582,0.0454676,0.04763909,-0.017969355,-0.05652268,-0.026639642,-0.03111711,-0.043620307,-0.044794828,0.060682826,0.11492139,-0.07020222,0.02809507,0.028736072,0.008936568,0.052653927,-0.055567116,-0.07967801,-0.006194492,-0.063340425,-0.017608928,-0.03138181,0.023733992,0.030551773,-0.01854514,-0.0418929,-0.03833946,-0.016810209,-0.056813415,0.02166704,0.00091962575,0.010164424,-0.036578525,-0.04248947,-0.004942337,0.06936204,-0.016823905,-0.013071493,0.042166643,0.02318645,-0.015995055,0.034948584,-0.09488203,-0.05613574,-0.028012257,-0.07720369,-0.07112263,0.0376154,0.04687257,0.028617486,-0.007418191,-0.049313053,-0.02560415,0.0021147346,-0.040426463,0.04277616,-0.016124409,-0.0454769,0.07241474,0.042740352,0.00706128,0.025183538,-0.006234612,0.04965407,-0.045394707,-0.0004545263,0.0149072725,0.025866706,-0.058340937,0.006251648,0.058577456,-0.015328587,-0.022305993,0.030334104,-0.01821718,-0.037391152,0.043307826,-0.07048466,-0.07168944,-0.12372975,-0.0316331,-0.013659548,0.054915637,0.028285751,5.4196953e-05,-0.049131513,0.04355915,0.009298432,0.030335274,0.030907946,0.023905119,0.021648204,-0.0089634955,-0.005430218,0.04706781,-0.016354585,-0.04446867,-0.004108724,0.15312001,-0.004382081,0.07029056,-0.06953269,9.551422e-34,0.061319344,0.0700156,0.02072617,-0.025471667,0.0026444662,0.014768018,-0.033203546,-0.010535274,-0.067400195,-0.048847944,0.009302664,-0.097744964,0.013385983,0.013761186,-0.00518094,-0.014837178,-0.034493066,0.061362956,0.050077807,-0.0032781062,0.048600838,0.08054308,-0.07993304,0.10850823,0.028775737,0.0727967,-0.00031069695,0.029722521,0.0025391844,-0.03888605,0.06830701,-0.080455,-0.0911077,-0.08085074,0.042623024,-0.059741355,-0.0278644,-0.0023767208,-0.04319147,0.026163716,-0.032085948,-0.03927947,-0.0020777097,0.017596744,0.0055357707,-0.06828054,-0.047854077,0.13957407,-0.030084848,0.04406291,0.024464792,-0.029618047,0.089276046,-0.053097207,-0.108464465,0.02837766,-0.016759597,-0.020003295,0.031022692,-0.019908158,0.106243245,0.03773153,-0.026697166,0.0026300012,0.0096917935,-0.02634798,0.030168425,-0.05029684,0.10031087,0.08930841,-0.030426957,0.040532146,0.017805422,0.06815426,0.022711739,-0.0254998,-0.081609674,0.020907156,0.03763107,0.021760093,-0.05728567,-0.06582435,0.021336392,-0.08499344,-0.04671896,-0.04412559,-0.035828326,-0.10355816,-0.010729351,0.016978743,0.041437887,-0.12333859,-0.05501646,0.015405382,-0.012219433,-2.0956491e-33,0.09284853,-0.10197303,0.09517812,-0.014744307,-0.07905228,0.036006037,0.008551279,0.054894187,0.021231787,-0.0051753833,0.046942543,0.017576165,0.05080414,-0.05001579,0.052944425,0.038547643,-0.017466558,0.0111355465,0.06573132,0.046469796,0.022820225,0.07280013,0.016124904,0.049083285,0.09016864,0.08216995,0.0056518693,0.065793075,0.002403165,0.0053371117,0.013421296,0.060679357,0.018995011,-0.030804483,-0.07316977,0.026734525,-0.061309125,-0.0036036642,-0.016804384,-0.00724298,-0.01825619,0.06980608,0.016813256,-0.00734605,-0.04921398,0.0144739915,-0.024929803,0.032135025,0.042493448,-0.09937243,-0.012042106,0.052854203,0.022781694,-0.030726006,0.034810316,0.049302634,-0.064864255,-0.025145587,-0.015076997,-0.05834384,-0.020438924,-0.07119572,0.017750196,0.10205611,0.040267292,0.089594185,0.0068235327,0.015500286,0.010223071,-0.031559296,-0.015834656,-0.0061643636,0.051302616,0.08584668,-0.06627137,-0.025385575,-0.032369874,0.024979088,0.018360786,0.018276155,-0.036035728,-0.021443158,-0.10372041,-0.09867482,-0.04699575,-0.067582235,0.040436637,0.12758252,0.031601604,0.020920092,-0.02111282,-0.0052803564,-0.052628484,0.03322251,0.06650121,-3.6192922e-08,0.106481984,-0.066711515,0.07924243,-0.046384912,0.055583343,-0.045774426,0.039449167,-0.018381266,0.08497517,-0.022840736,-0.0219176,0.034382716,0.0087446775,-0.0009095086,0.053468704,0.033068765,-0.019772837,0.0142907305,-0.006450873,-0.024329059,-0.054003272,-0.028157407,-0.13073279,0.041890547,0.07038157,-0.013319419,0.0038805895,0.03837764,-0.00024779473,-0.025124088,-0.0058119977,0.009673811,0.02857355,-0.02916482,-0.07315611,0.09378272,-0.056696974,-0.0352175,-0.007941318,0.053687703,-0.03216281,-0.036968946,-0.042963747,-0.033368453,-0.0074650473,0.013545235,-0.06684315,-0.0064591076,-0.03690039,-0.045597363,0.0021312218,-0.00030752763,-0.062458556,-0.044471983,-0.11260985,0.047083054,0.018590825,-0.06121065,-0.03751708,-0.0792713,0.035325523,-0.004566733,0.19756272,-0.046089552 +2.3.3.18,"The enzyme, characterized from the bacterium Streptomyces hygroscopicus, participates in the pathway for bialaphos biosynthesis. It requires a divalent metal ion and can also act on oxaloacetate.",384,1.0,0.0045743105,0.01980966,-0.1562178,0.0088545,-0.03549473,0.043269653,0.00100583,0.047220808,0.042067446,-0.037554935,-0.014171337,-0.04075084,-0.027988847,0.046207897,-0.039154176,0.022525044,-0.0699331,0.009462895,0.028006015,-0.03151543,0.15290597,0.073877946,-0.04221396,0.006046549,0.020944953,-0.0027439005,0.049705856,-0.021246044,-0.05694068,-0.011636103,-0.024476754,-0.0056757443,0.0769903,-0.07229133,0.096285254,0.10782043,-0.016767785,-0.044931915,0.06146402,-0.00072802335,0.033019423,0.013977806,-0.012799806,0.006967301,-0.05686363,0.0041164467,0.07683995,0.060685888,-0.012185785,-0.008802485,-0.08223281,-0.07524832,-0.036997404,0.030727085,0.04118192,0.078904174,0.0022402154,-0.006166214,0.036649834,-0.1278011,0.021963641,-0.04614494,0.07383588,0.042068228,0.0020307521,-0.0660257,0.013773416,-0.07377979,0.027592896,-0.060178474,-0.051491514,-0.038386464,-0.039967522,-0.009900788,0.00239977,0.039000623,0.05983516,-0.09183888,0.046991386,-0.036797352,0.022860816,-0.015153664,0.017528735,0.04336084,0.010080541,0.023624953,0.0060608583,-0.046657585,0.00033987698,0.016913133,0.036761533,-0.06944932,0.032784704,-0.11476627,-0.044655286,0.04387111,0.002657628,-0.022905571,0.06544551,-0.008742742,0.0026617583,0.058028847,0.043517485,0.013532716,-0.02503341,0.0054585696,0.0052321586,0.07443344,0.04251348,-0.012674331,0.0126971435,0.0071012503,0.07554,0.011008295,0.032422725,0.08662121,0.0772187,-0.063425854,-0.10635147,0.0001157485,-0.0061782617,-0.0030548251,-0.0041422867,0.015999325,-0.00720898,0.053434793,-0.117590405,1.9206343e-33,0.036113203,0.021455802,0.022000667,-0.09518151,0.06282517,-0.037867423,-0.04998421,-0.05470894,-0.018257555,-0.07375045,-0.06552881,-0.05811476,0.038879395,-0.001393828,-0.013866819,-0.014657323,-0.03412342,0.077640876,0.05978578,0.055386115,-0.011334574,0.02856746,-0.02462472,-0.0012351813,0.027002357,0.063271165,0.0005785627,0.00036855816,0.0015931288,-0.025062943,0.060357165,-0.009509751,-0.09927567,-0.012798489,0.07402369,-0.085195586,-0.024706353,-0.055570304,-0.0023733168,-0.036387477,-0.032229804,0.013441498,-0.06720899,0.021346172,0.10749008,-0.09971049,-0.06284566,0.10587203,0.048298683,0.10935803,0.004232037,-0.0020036297,0.11126797,-0.056962248,-0.059005152,0.007396599,-0.011186852,0.011413599,0.0846047,0.03323643,-0.014530403,0.09002158,0.010074589,0.06368334,0.054059725,-0.01454772,-0.019417059,-0.04185245,0.00054069475,0.032724597,-0.0644382,-0.025832212,-0.03803875,0.040447567,-0.030261919,-0.036584277,-0.049362563,-0.046675242,0.043223012,-0.017897,0.0045061894,-0.0004911412,0.060364567,-0.072612554,-0.008384085,-0.011313639,-0.050960664,-0.088297546,-0.05224541,0.032672524,0.013097373,-0.00022748638,-0.084339134,0.05100355,0.04915381,-4.022821e-33,0.115757905,-0.09477254,0.082971126,-0.05057039,-0.059746753,0.07936774,-0.06733351,-0.03089204,0.019320497,-0.037434854,0.054154597,0.010253347,0.017990636,-0.085184425,0.037647158,-0.024592737,0.02920435,0.10844403,-0.016603785,0.016295638,0.00383253,0.07842307,-0.023864547,-0.01611154,-0.006942032,-0.020788603,-0.039747015,0.015018728,0.0020054264,0.067112006,0.028592853,0.0034346955,-0.026847119,-0.03735875,-0.0051197135,0.05066484,-0.04370983,0.017980864,0.09583357,0.0037685975,0.07578292,0.0078752255,0.045424823,0.04815328,0.002454419,0.060584318,-0.095511295,0.08960932,-0.008724764,-0.03151758,-0.015029299,0.029392375,-0.025752872,-0.00029172047,0.029838419,0.034283783,-0.006755583,0.017304586,-0.06014169,-0.033759438,-0.089320675,-0.02340671,0.033682372,-0.006386328,0.045457356,0.021560395,-0.011313257,-0.0021374715,0.08332259,-0.06379711,0.09132459,0.037791956,-0.016104387,0.017902182,-0.01802351,-0.017557954,-0.0887978,-0.047137145,0.036467783,0.007272651,-0.014029032,0.054473832,0.06285718,-0.05812306,0.019974569,-0.10662325,-0.008824459,0.07271477,-0.021872006,0.020671416,-0.007144364,-0.08348264,-0.0462634,-0.03325875,0.048689086,-3.4253272e-08,-0.022780342,0.0015093705,0.098449655,-0.05935729,0.014519751,-0.019114785,0.012421888,-0.016224243,0.058120005,0.011819667,0.004464623,-0.006043566,0.012888325,-0.03909268,0.038246904,-0.0004992414,-0.06441267,0.019732444,-0.032452103,-0.010545357,-0.04614587,-0.08409229,-0.09236087,0.09810927,0.066505246,-0.077336125,0.042573497,0.025769997,-0.026678516,0.027353428,0.033054,-0.006655299,-0.035165053,0.002049404,-0.08327422,-0.05155258,-0.041250598,-0.036904234,-0.011834206,-0.033579186,0.002393975,-0.051167965,-0.019845832,-0.0067063295,-0.1005335,0.059650395,-0.039693583,0.03149579,-0.050798535,-0.027904404,0.058098935,-0.05925174,0.025578381,-0.037259534,-0.108584605,0.037803885,0.091450006,-0.055062145,-0.011879627,0.006001822,0.08216889,0.024211166,0.18878023,-0.093431205 +2.4.1.343,"The enzyme is involved in the the biosynthesis of the O-antigen repeating unit of Escherichia coli O3. Requires a divalent metal ion (Mn2+, Mg2+ or Fe2+). cf. EC 2.4.1.303, UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase.",384,1.0,-0.019115053,-0.07610891,-0.10709057,0.0313577,0.03983376,-0.0060341437,-0.015097941,0.03930363,0.058515992,-0.07406332,0.031838164,-0.019634185,-0.0147542665,0.041387882,-0.04639557,-0.015819281,-0.022863243,0.055176146,0.00081662845,-0.009889877,0.12563644,0.04944425,-0.010874797,-0.017625852,0.029277673,0.030421723,0.054223392,-0.039830275,-0.000563799,-0.058892034,-0.030078586,-0.06367545,0.13891578,-0.10959494,0.09638782,0.032053128,0.021556757,-0.041781243,0.008357553,0.022403156,0.014797362,0.0076199686,0.08059473,-0.019957233,-0.010637095,-0.040552985,0.031874087,-0.0012426499,0.03953126,0.02556991,-0.027446764,-0.0847915,-0.03559699,0.057756517,0.07600821,0.0005647833,-0.06090031,-0.092410885,-0.021970311,0.0051441574,0.024770208,0.024944877,0.013430938,0.027049284,0.05673947,-0.05602293,0.05303853,-0.074599616,-0.0006288469,-0.052918546,-0.04938046,-0.023512512,-0.033298183,0.0074207466,0.0089561,0.044764373,0.11719465,-0.033815257,0.1213585,0.020959936,0.03135502,-0.030666688,-0.006038569,0.051510595,-0.03361427,0.027342057,0.0044464986,0.039053053,0.014041318,0.044032793,-0.011595695,-0.05586936,-0.008348101,-0.073066935,-0.016731078,0.03297137,0.012829342,-0.009090483,0.057231516,0.024632111,-0.032670602,0.050772585,0.023363272,-0.0043979553,-0.042104438,-0.037565026,-0.0026646727,0.10615771,-0.04745928,0.034391157,0.05675822,-0.042301677,0.03148445,-0.0049023926,-0.050516643,0.08808269,0.020124726,-0.114840575,-0.066065244,0.011483654,0.06496435,-0.03753995,-0.024844501,0.08941698,-0.010522345,0.060563732,-0.03525674,2.1373433e-33,0.057176698,0.06829605,0.03267651,-0.035374377,-0.02274703,-0.006433183,-0.030650973,-0.071359806,-0.009213111,-0.0074991444,-0.09053996,-0.07619008,0.058374736,0.012696983,0.008822211,-0.0043607736,0.002418324,0.004236305,0.037231255,0.05154258,0.0027551302,0.08013077,-0.024798205,0.0050638486,0.058473844,0.07709311,-0.031050421,-0.02915487,0.065328896,0.002304801,0.09240264,-0.070862204,-0.10280234,0.012664626,0.12350913,-0.05570139,-0.011918947,-0.07993148,0.02212287,0.01768489,-0.025085717,0.04221082,-0.050834607,0.058337603,0.0832631,-0.08245018,-0.034993768,0.05138976,0.05457077,0.08855486,0.050871335,0.05374532,0.028366925,-0.03117867,-0.05788934,0.0031527455,-0.097461015,0.035020832,0.03754173,0.04839223,-0.048749633,0.04195946,-0.0057243295,0.06554825,0.021770652,0.008273541,-0.020556321,-0.03137946,0.0072583673,0.04350948,-0.012748901,-0.10974302,-0.00032189893,0.02120616,-0.041007627,-0.027806496,-0.018536344,-0.021758309,0.07402509,-0.05120447,-0.0382719,0.019264918,0.002112589,-0.028254708,-0.07183805,0.029101687,-0.01368967,-0.06154471,-0.008083498,0.052703734,0.029308034,0.009373203,-0.04798457,0.03567273,-0.0017917528,-3.439801e-33,0.08924801,-0.111148685,0.06502933,-0.1151598,-0.09921795,0.02288829,-0.04529585,-0.01753243,0.033152334,0.029422117,0.03276535,-0.012622519,0.025167419,-0.09547284,-0.015816567,0.00771885,-0.00545859,0.10049103,-0.0033937718,0.03303413,0.0697499,0.05638864,0.06352222,0.00791192,0.014741691,0.023594802,-0.008825505,0.034042772,0.0138322245,0.045655597,-0.00820965,-0.04085745,-0.00031989106,-0.08066602,-0.067418285,0.025785703,0.06137477,0.016778784,0.02198812,0.020862928,-0.03681666,0.037027523,0.012578848,0.071926646,0.003795087,0.075842366,-0.037573192,0.056587324,0.067600965,-0.08758077,-0.014208982,-0.056133673,-0.016322482,-0.0070215114,-0.0039808042,-0.009293738,0.05913077,0.020069165,0.0029891394,-0.029097617,0.0132123465,-0.074000284,0.058644522,-0.052668396,0.07397925,0.060860846,0.025892662,0.004311046,-0.0061354325,-0.017797016,-0.0060842927,0.017874826,0.0045923754,-0.003240479,0.021227643,-0.03167165,-0.12357862,-0.053634383,0.049116313,0.0044564498,0.00668603,0.03316873,0.006348255,0.0067239935,0.024860594,-0.12185986,0.096014865,0.17967117,-0.0026955034,0.023930253,-0.08458684,-0.033418912,-0.050220747,0.028996594,0.04714774,-4.309149e-08,0.022355147,-0.07501934,0.016875569,-0.10562158,-0.040151644,0.050952602,-0.03439511,-0.060823098,0.05557771,0.0045772647,0.02951815,0.10935474,-0.016039662,-0.05745139,0.0731076,-0.003429943,-0.011686583,0.0075594936,-0.057414405,-0.016902335,-0.034452304,0.010015879,-0.09451962,-0.02507437,-0.0001300942,-0.030560391,0.008333809,0.07607995,-0.047478534,-0.044236824,-0.025498945,0.018709201,-0.024813276,-0.07207694,-0.13640487,0.011057113,-0.029349918,-0.056540996,0.005626967,0.0054993066,-0.045244228,-0.00516123,0.0048953905,0.000547022,-0.052093286,0.028714452,-0.06273785,0.034543615,-0.07293121,-0.033495434,-0.00617809,-0.13118668,-0.049882546,-0.04298203,-0.09837317,-0.043252688,0.011122557,-0.07939088,-0.015760142,-0.012753732,0.018514594,-0.012464091,0.1415321,-0.04805765 +2.4.1.344,"The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 2 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 2 antigen. Humans possess two enzymes able to catalyse this reaction, encoded by the FUT1 and FUT2 genes (also known as the H and Secretor genes, respectively), but only FUT1 is expressed in red blood cells. cf. EC 2.4.1.69, type 1 galactoside alpha-(1,2)-fucosyltransferase.",384,1.0,-0.026958544,-0.02098671,-0.15369263,0.023105143,0.016837044,-0.015836086,-0.01102715,0.09193854,0.020943115,-0.020585343,0.021891888,0.0031342919,-0.12592256,0.023742136,-0.058050264,0.0131902,-0.030815326,-0.009544594,-0.0037367695,-0.07906457,0.06835886,-0.029448997,-0.012897214,0.0015328677,0.03205538,-0.041649923,-0.006390312,-0.026865702,-0.026815834,-0.076290354,0.008554251,-0.11779127,0.049793497,0.028180009,-0.027734792,0.01235792,-0.021220189,-0.03253894,0.012719217,-0.03412135,-0.010078747,-0.027704403,-0.019823458,-0.026824996,-0.020000732,-0.025918836,-0.0068530953,0.088961236,0.01904916,0.05887553,0.006759191,-0.01250191,-0.05729559,-0.012913273,0.09638803,0.05493359,-0.08410733,-0.015631247,0.02860942,0.02232142,0.0021889324,0.022473559,-0.047717616,0.005218424,-0.0016855708,-0.08287641,0.065002464,-0.06341347,-0.008940529,-0.04799856,-0.03444084,-0.027664138,-0.030496698,-0.06138661,0.063001186,0.07425083,-0.011394722,0.06368859,0.029604854,0.008700212,0.08576986,0.03347887,0.086677305,0.09500283,-0.0052382643,0.015245232,-0.0035016006,0.030914731,-0.023341512,0.040916055,0.013759194,-0.03370067,0.031859722,-0.002844259,-0.04448889,0.0039671846,0.03954134,0.06390479,0.074237436,-0.029659579,-0.021411985,-0.0059206546,0.032267727,-0.057565533,-0.041205447,0.042670317,-0.037392598,0.073548585,0.11328849,-0.025388043,-0.023118516,0.01403891,0.029891733,-0.033808827,-0.041982446,0.10564859,-0.009408269,-0.013099505,-0.019788262,0.005705138,0.054911073,0.01640365,0.08601864,0.02203406,0.015453458,0.012477392,-0.07724775,2.3107446e-33,0.07774942,0.050747845,0.025759695,0.06645783,-0.03362659,0.016133351,-0.03859072,-0.054727722,-0.0013412109,0.0118448865,-0.03577244,-0.09880602,-0.021354204,0.09890703,-0.05666118,0.045268428,-0.008186838,-0.112620406,-0.026004707,0.0021203673,-0.028243331,0.08424625,-0.022884455,-0.102063306,0.03378257,0.025404511,-0.07382644,0.07743653,0.06203322,0.027406352,-0.029237092,-0.09947399,-0.054799587,0.04486899,0.0055573843,0.07300883,-0.044283602,-0.09053197,0.0490171,0.021597704,0.022045257,0.019870317,-0.056099705,-0.046548177,0.08350015,-0.028903155,-0.0007876144,0.035988957,0.008847582,0.104503825,-0.016867263,-0.01954556,0.08827544,-0.035594128,0.011371573,0.0109588895,0.004127521,0.037133362,0.038199678,0.12714449,-0.013016474,0.09743211,-0.0040245545,0.032778196,-0.048774406,-0.02746797,-0.056616705,-0.09080355,-0.029587254,0.06789823,0.028790265,-0.028886229,0.049257644,-0.0459805,0.020063074,-0.06852774,0.03333323,0.022596449,0.022714129,-0.045880023,-0.020261878,-0.0028233267,0.018805528,-0.034070898,-0.08891234,-0.023035116,-0.06267478,-0.1244595,-0.061902918,0.068449035,-0.05165989,-0.047920484,-0.044671644,0.016518116,0.062798865,-4.7117465e-33,0.024830246,-0.064106695,0.01659873,-0.08159186,-0.06739875,0.038009148,0.048580196,-0.006227602,0.016427396,0.04471695,0.036933586,-0.037264355,0.010835423,-0.042331234,0.022256576,-0.022931436,-0.009593359,0.05665479,-0.063285254,0.055063486,-0.040980484,0.10080458,0.050420042,0.068394855,0.009165723,-0.012053449,0.0201511,0.040190477,0.054522067,0.012049596,-0.073625974,0.06952126,-0.03623253,-0.06644204,-0.010739074,-0.05104561,-0.0217924,0.021264201,0.029060181,-0.022290388,-0.018269433,0.08662371,0.07127988,0.046318702,0.047810715,0.09848217,-0.0033071958,0.04021329,0.007818008,-0.028649203,-0.044961203,0.0016202301,-0.013836408,0.11855851,-0.0008130851,0.016978575,0.042749822,-0.0082235215,-0.040919814,0.02704979,-0.062145103,-0.08329341,0.0014337512,-0.01787914,0.080984496,-0.029025339,-0.036474198,0.028785218,0.056902662,0.06004438,0.052181046,-0.06085753,-0.0062007834,-0.022757674,-0.03576694,-0.05129079,-0.1401049,-0.016637772,0.044666275,0.018949851,0.03736782,0.02678543,0.049123228,-0.010261071,0.08209171,-0.14827904,0.008420572,0.1332091,-0.024500562,0.05614487,-0.011572756,0.001269658,-0.05485757,0.03227952,0.0057057883,-4.6249067e-08,0.06873758,-0.12664707,0.028003091,-0.07186634,-0.03424069,0.045568217,-0.083145015,-0.037891824,-0.010799156,0.05875399,-0.10351963,0.10925907,0.00048987055,-0.06726786,0.013380182,0.07685531,-0.013179532,0.0013380947,-0.026962282,-0.014922024,-0.06658488,-0.048272096,-0.07836757,0.05887451,-0.009965173,-0.054846164,0.0041827997,0.033298686,-0.01127273,-0.0073303077,-0.0011722449,0.06595969,-0.024069622,-0.019954924,-0.09839928,-0.029094381,0.050473634,0.00705115,0.015965674,-0.013126515,0.0068340776,0.011166166,0.017403431,0.010230917,-0.026683183,-0.0009070083,0.011872873,0.0039186226,-0.03795593,0.00468454,-0.029228726,-0.056328952,-0.065345,-0.04396691,-0.09081327,-0.045979943,-0.025812957,0.024544645,0.06555106,-0.057168107,0.012108551,0.0389161,0.15975775,-0.025936363 +2.5.1.136,"The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids. It also acts with much lower activity on naringenin chalcone. Forms a complex with EC 2.5.1.137, 2-acyl-4-prenylphloroglucinol 6-prenyltransferase, which catalyses additional prenylation reactions. Requires Mg2+.",384,0.99999994,-0.062247142,-0.024602415,-0.019563375,0.024037471,0.016903495,0.033982348,-0.023941197,0.012264606,0.059077285,-0.011262232,0.025298564,-0.051092923,-0.033966523,-0.012940251,-0.010832649,0.0501375,-0.06525283,0.036875747,-0.082569,-0.10749983,0.073024675,-0.017732095,0.005555575,0.035975646,0.030657094,-0.023673033,0.028120926,0.03395201,0.029625827,-0.11214632,0.075652696,0.034274064,0.06739593,0.02631923,-0.04044931,0.06304757,-0.036845982,-0.010760668,0.08668573,0.003798703,0.08383358,-0.038479578,0.010294583,-0.07178772,0.035246603,-0.06148926,-0.030521538,-0.019093633,0.032879792,0.0822544,-0.028657591,-0.0033224495,0.020224739,0.0053635403,-0.036304742,0.073490396,-0.045749195,0.012348159,0.05161873,0.0058505307,0.07675838,-0.04437368,-0.038099267,-0.024194099,-0.019600999,0.042803116,0.0012359108,-0.08952981,0.14624627,-0.09304602,-0.0096657025,-0.08765554,-0.002111963,0.06207672,0.0434035,0.054302786,-0.012361454,0.021962762,-0.030616535,-0.005023126,0.0064448314,0.047927245,0.008352267,-0.0007781358,0.02745918,0.042165168,0.03295211,-0.038905114,0.040727705,0.013302736,0.012692038,-0.023622075,0.012906132,-0.04905045,0.0034210195,0.11851379,-0.04415801,-0.031187756,-0.003868605,0.02820679,0.08884385,0.016437365,-0.04696249,-0.08549412,-0.043523878,0.04176445,0.027796382,-0.001077012,-0.034888525,-0.009598547,0.015536571,-0.04347648,0.07957013,-0.026254648,-0.0039636674,0.13675088,-0.009868855,-0.06405765,-0.023443952,-0.023776248,0.04686212,-0.04858719,0.022760283,0.017615931,-0.067587346,-0.0033211678,-0.08870273,7.500326e-33,0.062363014,0.017563593,-0.01592784,0.043271475,-0.03201802,-0.004706963,-0.12907138,0.071549356,-0.051306892,-0.044275172,-0.081015855,-0.014210627,-0.043410573,0.013187463,-0.049596988,-0.023741564,0.032754883,-0.046542287,0.07476055,-0.06666049,-0.032425962,0.007983468,-0.012838096,-0.03297715,-0.023535036,0.1117502,0.030593747,-0.06157455,0.04856723,-0.0015711931,0.056291025,-0.08749287,-0.012814662,0.06244567,-0.010065371,0.030519271,-0.070711575,-0.0064806333,0.03101278,0.06392789,-0.08957999,0.045621343,0.0035472522,0.007026985,0.031226698,-0.10467189,-0.05525578,0.0165947,0.08806561,0.07777166,0.0426567,0.008301651,0.1322221,0.026686706,-0.035316437,0.0035762307,0.01590494,-0.056225877,0.040629704,0.03393881,-0.0055757873,0.04362986,-0.048859417,-0.020015297,0.030860448,0.08147919,-0.046411037,0.022169856,0.0046332534,0.01167614,-0.046206065,-0.017136589,0.027487058,0.016585683,0.05525702,-0.010468447,-0.040331494,0.03350438,0.020068051,0.036791492,-0.060327698,-0.027241074,0.009549551,0.06263565,-0.086468406,-0.039822306,-0.020273898,-0.068414904,0.027396886,0.04891169,-0.020875903,0.019126471,-0.061591037,0.073808484,0.019705407,-5.6592985e-33,0.111772805,-0.04723217,-0.0018039265,-0.035543602,-0.044331927,0.024617087,0.064413734,-0.073191606,0.00041398985,0.05772438,0.07735396,-0.008556864,0.07963163,-0.07315136,0.12654252,0.022612011,0.08089983,0.054367878,0.013098545,-0.013274466,-0.017445037,0.1026271,-0.089506894,0.046280164,0.023876177,0.027304,0.07778081,-0.02406381,0.088028595,0.06873031,-0.04353386,-0.0049409806,-0.0150166415,-0.018302346,0.019110028,0.010277708,-0.020278431,0.036806397,-0.09001753,-0.02548895,-0.016074106,-0.04590718,-0.024801655,-0.001716978,0.09848157,0.028103687,-0.059086006,0.0013389157,-0.06672138,-0.04145872,0.1226922,0.064127855,-0.0058687017,0.00043373666,0.0938614,0.006733546,0.02230033,-0.05047468,-0.005344735,-0.09095024,-0.11543189,-0.06946341,0.015641227,-0.10222761,0.022703812,0.042000312,-0.06642847,0.05593982,-0.012860479,-0.02861249,0.09510702,-0.010566876,0.049781416,-0.05250715,-0.06645833,-0.031971466,-0.0019978662,0.021798693,0.08053338,-0.025444508,-0.018501665,0.0009323116,0.03152814,-0.08415181,-0.047089543,-0.0470383,-0.04130314,0.07740473,0.03968206,0.0058040093,-0.030480621,0.014695542,-0.07909342,-0.012079131,0.06895558,-4.8160597e-08,-0.03650732,-0.05981333,0.016679347,0.047165103,0.0183281,0.058808137,0.019994656,0.010578037,-0.066190556,-0.010564162,0.0053713107,0.076888196,0.0550495,-0.009166548,-0.028836943,0.020738108,-0.013170561,0.06258674,-0.005836434,-0.00338579,-0.07057982,0.031304363,-0.13848692,-0.0005712568,-0.03734022,-0.14708643,0.036643356,0.012288736,-0.032615133,-0.0017066189,0.017170792,0.002551006,-0.017060507,-0.025149917,-0.03697203,0.02224163,-0.017643541,-0.0037200279,-0.009802497,-0.030833408,-0.022209093,0.026410079,-0.03551038,-0.011634635,-0.07182542,-0.03974945,0.08576238,-3.1694817e-05,-0.008467332,0.03675297,0.02636274,0.018404912,0.0053634006,-0.014375531,-0.07563568,-0.020855356,0.011856821,-0.1338562,-0.038656954,-0.05174291,0.05521517,-0.02948393,0.15312222,-0.031453036 +2.5.1.137,"The enzyme, characterized from hop (Humulus lupulus), catalyses two successive prenylations of a 2-acyl-4-prenylphloroglucinol during the synthesis of bitter acids. Forms a complex with EC 2.5.1.136, 2-acylphloroglucinol 4-prenyltransferase, which catalyses the initial prenylation of the substrates. Requires Mg2+.",384,1.0,-0.006777188,-0.036273647,-0.022936735,0.035364766,-0.009840856,0.06219839,-0.009249169,0.010807161,0.055602618,0.022789659,0.05349712,-0.06154078,-0.05783264,-0.04240416,-0.042494927,0.07095695,-0.04830661,0.015562896,-0.058418777,-0.120097935,0.06467673,-0.016892597,-0.039454136,0.042371128,0.03323632,-0.015264123,-0.03873709,0.04539132,0.028168015,-0.09272677,0.07321561,0.017711427,0.09990239,-0.01053665,-0.0017502723,0.044806592,-0.016243448,-0.020284085,0.10226954,0.0058746412,0.050473418,-0.07153087,-0.017702743,-0.026477152,-0.035044197,-0.053392205,0.0121122375,-0.008954426,0.036846556,0.06624471,-0.06189666,0.022226833,-0.01366578,-0.017680291,-0.020325858,0.036684647,-0.018026127,0.0350713,0.045490015,0.03126729,0.04098057,-0.04157752,-0.05080379,0.005980617,-0.029672695,0.021812389,0.03315076,-0.11930969,0.12125894,-0.0630794,-0.029926794,-0.11668535,0.004197391,0.049510058,0.030974614,0.02566039,0.0022300272,-0.017498983,0.021285234,0.023102643,0.013849368,0.06393201,-0.00072708545,0.0033077404,-0.025710912,0.025070488,0.045424487,-0.0735603,0.06252126,0.0018447455,0.015355196,-0.07615683,0.02699653,-0.023398416,0.027666094,0.10365997,0.00674277,-0.049058948,0.08936806,0.0051667304,0.043283984,0.0139023755,-0.03189165,-0.10144614,-0.07771803,0.013572234,-0.024136107,0.039194666,-0.03594333,0.0009467737,0.010400473,-0.04011247,0.054694925,0.0041746,-0.007958582,0.10712193,0.00043192838,-0.09382498,-0.01752608,-0.02601652,0.029696744,-0.05623504,0.04690571,0.034521405,-0.068666525,-0.035097115,-0.09954458,3.7471803e-33,0.08084579,0.026947498,0.016251693,0.03006246,-0.03490414,0.009108238,-0.11236774,0.034764376,-0.05165659,0.051250353,-0.060909953,-0.033234745,-0.058027603,0.01774147,-0.043281935,-0.06327889,0.010993081,-0.039077207,0.072431855,-0.035360944,-0.06798481,0.03907847,-0.008749436,-0.05667728,-0.020209173,0.15981135,0.04430316,-0.1018699,0.061068676,0.036262296,0.01815875,-0.0687016,-0.043818485,0.04264808,-0.010088918,-0.019759854,-0.05537809,-0.020178182,0.05634356,0.04159236,-0.0738812,0.046746336,0.020517558,-0.016300438,0.024803208,-0.08140794,-0.102972366,0.014906801,0.06353355,0.10446653,0.03775957,0.0070101577,0.14773929,0.035104513,-0.026429446,0.0033110168,-0.04381093,-0.0491671,0.010339514,0.045531947,-0.025336243,0.06972309,-0.045938052,-0.0393348,0.02529864,-0.0051059118,-0.033988707,-0.022641221,0.03340976,0.030699663,-0.016233638,-0.018777426,0.046983518,-0.013712366,0.034115065,-0.031962197,-0.02139752,0.06995883,0.024491062,0.0519068,-0.08312844,-0.011308733,0.015672024,0.047293052,-0.07757118,-0.03131797,-0.028999846,-0.04858652,-0.017333591,0.095001094,-0.08649751,0.04016098,0.0031381715,0.09178267,0.017244132,-3.7984113e-33,0.11938019,-0.05376677,0.018222632,-0.010199044,-0.067658484,0.0048766364,0.09633316,-0.059695963,0.0028297263,0.10636608,0.06995183,0.016485741,0.05612512,-0.056410026,0.10948824,0.0070895036,0.062238786,0.044362795,-0.033593196,0.0074927425,0.013261423,0.06542471,-0.072646104,0.049952734,0.065041944,0.014889035,0.087294236,0.0034370993,0.040141903,0.08764258,-0.008445446,0.006560001,0.0029440236,-0.0038735329,0.022773731,-0.036121678,-0.0344973,0.05390285,-0.069906056,0.023866642,-0.016287375,-0.0019633998,-0.0047373506,-0.017041644,0.073645696,0.021034157,-0.037853327,0.03874282,0.0022565098,-0.09013663,0.08149603,0.03928355,-0.043720294,-0.00848404,0.06146002,0.0069248206,0.015060538,-0.050050654,-0.015973793,-0.084796414,-0.12147676,-0.08016001,0.05890244,-0.096319295,0.048540916,0.019094551,-0.035456285,-0.022103833,-0.027716123,-0.018765323,0.09502052,-0.00047197047,0.03432392,-0.028943406,-0.010931232,-0.018342247,-0.025426917,-0.0002723188,0.07115094,-0.04607495,-0.013708196,0.015710792,0.02274558,-0.08955777,-0.02294082,-0.07137997,-0.01311742,0.10175257,0.01470166,0.013940742,-0.041061983,0.04087828,-0.043167412,-0.0098647745,0.07937697,-4.231227e-08,-0.021284718,-0.050729036,0.01755346,0.06532594,0.030481085,0.09896974,-0.013002547,0.019851815,-0.028632728,-0.020407155,0.00028442487,0.0842204,0.06328561,0.025072271,-0.026318455,-0.0023218815,-0.03488792,0.024939297,0.0028320411,-0.0051470185,-0.066713065,0.011918873,-0.10763756,-0.010474867,-0.072143264,-0.15622272,0.04801839,-0.0017015082,-0.026427535,0.017030407,0.014355441,0.05118294,-0.048776377,-0.03192453,-0.037438937,-0.001981959,-0.024235401,-0.028473802,-0.034599427,0.0014513377,-0.02662547,0.030035643,-0.02542968,-0.021435175,-0.06736249,-0.040125053,0.044089053,0.014561124,-0.04219508,0.07237387,0.019402727,0.05708032,-0.008018734,-0.015718443,-0.0320958,-0.022167334,0.001914114,-0.112503305,-0.057807337,-0.04716945,0.05912961,-0.002323393,0.1310394,-0.0633635 +2.5.1.138,"The enzyme, characterized from the plant Citrus limon, is specific for geranyl diphosphate as a prenyl donor. It also has low activity with the coumarins 5,7-dihydroxycoumarin and 5-methoxy-7-hydroxycoumarin.",384,0.99999994,-0.08584718,-0.030118303,-0.06313179,-0.016400874,0.055242572,0.08953534,-0.05568911,0.07774793,0.08613286,-0.09407307,0.028403014,0.006533998,-0.15390496,-0.0013339615,-0.05298667,0.053381115,0.020472206,0.00982023,-0.048149858,-0.039062113,0.024099935,-0.032699976,-0.0027584657,0.0025350824,0.023428114,-0.032708455,0.019513017,0.038853657,0.06790187,-0.014711518,-0.034916293,0.04531892,-0.031065373,0.04064638,-0.017857885,0.03755339,0.006943447,-0.10956618,0.043652654,0.030512368,0.06977802,0.005187494,-0.04426495,-0.027511364,-0.047972295,-0.075064555,-0.020442046,0.026228024,0.050220963,0.005820331,-0.02730116,-0.000119858414,-0.034715377,-0.08736857,-0.003245065,-0.014355373,-0.04299574,-0.016601067,0.024297336,0.029221322,0.05339081,0.01445191,-0.07471872,0.0035160868,-0.034555264,0.01204845,0.023576563,-0.029224228,0.08652436,0.0013799829,-0.036309008,-0.046926502,-0.00044912886,0.006247795,-0.0456995,0.0904484,-0.045056146,0.0093036285,0.022492716,-0.070501104,0.048541,0.08631419,-0.036079947,0.06067274,0.0058254628,0.03511159,-0.06325434,0.086139195,0.044651546,0.03278112,0.036602087,0.0035608038,-0.037249856,-0.10452546,-0.10943303,0.10481945,0.021975467,-0.03144903,-0.029190153,0.031199927,0.012408783,0.101406194,0.0156099405,-0.10458626,-0.102606945,0.013639535,-0.013453784,0.018285105,0.039930526,-0.001704367,-0.021849107,-0.0013970437,0.020371044,-0.029953564,-0.07112248,0.06657581,-0.044102512,-0.08819505,-0.06836736,0.010002977,0.049253237,-0.08782497,0.02526649,0.06754037,-0.012913978,0.028593102,-0.08370698,1.8666312e-33,0.09117956,0.007041332,0.059819415,0.037616864,-0.0017644742,0.0057751117,-0.058792483,0.02142427,-0.053759612,-0.03423096,-0.038756236,-0.055637512,-0.0057360763,0.026375607,-0.057204723,0.00816656,-0.016758434,-0.041651346,0.07137974,-0.009022836,0.04629522,0.039131597,-0.074046515,0.009635883,0.005090196,0.067116,-0.07006925,0.060416855,0.07770257,-0.008636963,0.012317644,-0.077115595,0.015041053,0.016591614,0.0206189,0.0056002485,-0.05278679,-0.027963372,-0.0036204334,0.03858016,0.07156853,-0.013532211,0.032155115,0.052863076,0.062369555,-0.10390462,-0.05824445,0.0012290571,-0.038602173,0.007786363,0.012650622,-0.018281776,0.09149406,-0.003243585,-0.010837908,0.028412411,0.005642713,0.04196931,-0.018326716,0.027994018,0.016004087,0.0045144763,-0.07513626,0.045634657,0.02085532,0.016226865,-0.050886773,-0.01783222,0.02519106,0.11137218,0.01987855,-0.022428809,0.01764033,0.09265828,0.040574383,0.0048254994,0.040311106,0.008854719,0.045319427,0.047571052,-0.092969686,-0.029247379,0.048587713,0.009125097,-0.09885592,-0.03155553,-0.032681838,-0.040898684,-0.020778356,-0.03375954,0.009709066,-0.085344,-0.04291078,0.002103213,-0.036785346,-3.101274e-33,0.056956556,-0.06293337,0.041846085,-0.08091029,-0.048706755,0.11520174,0.08432515,-0.10399653,-0.030773005,0.012604773,0.08433271,-0.032367446,0.04559477,-0.015954152,0.019110827,0.06095178,-0.008534607,0.041806463,-0.019288678,0.040108882,-0.090520695,0.13501231,0.09679717,0.03245003,0.04378676,-0.008053621,0.030832436,0.008054915,-0.061341997,0.100653626,0.0302081,-0.04102051,-0.050299168,-0.05980099,-0.026606962,0.010244452,-0.024288485,-0.047116805,-0.022517003,0.009461797,0.0050256024,-0.03188842,0.0038129939,0.053532153,0.027863748,0.0820802,-0.096620806,-0.026968773,0.023894183,-0.035323486,-0.022203762,0.053329002,-0.016104894,0.08722625,0.052908808,0.008194653,0.077042475,-0.04678975,0.011494564,-0.020964442,-0.06456388,-0.041924387,0.0031125292,-0.011954635,0.06555465,0.08322034,0.079314604,0.10458884,0.014717541,-0.11452764,0.07727137,0.0018575675,0.045270354,0.08353912,-0.06906982,-0.013166485,0.024809983,0.020171888,0.002862105,-0.03252816,-0.02669003,-0.039930377,-0.09790204,-0.04643195,-0.021921627,0.0072599547,-0.007930396,0.083645284,0.07703383,0.08062386,-0.048649352,0.07386912,-0.043396097,0.004184101,0.07377466,-3.73328e-08,-0.0026112653,-0.04328818,0.07062913,-0.06721314,-0.022840789,0.011887234,-0.0294333,-0.0074380604,-0.039242107,0.084259875,-0.03793337,0.03324616,-0.058161903,-0.0025446762,-0.013565857,-0.049631402,0.010685749,0.043578606,-0.049735192,-0.07487152,-0.0486047,0.05240249,-0.02534313,-0.021651464,0.021990355,-0.14269151,0.0028066821,0.039594952,0.0163851,-0.022591677,-0.028137662,0.026830355,-0.008353554,0.005101503,-0.063059136,0.08323152,0.024522379,0.015287411,-0.066100664,0.051448856,-0.034961544,-0.03808737,-0.10953811,-0.034301274,-0.030901771,0.004600673,0.056437373,0.046314307,0.03727587,0.037891585,0.038782578,-0.015435676,0.0052937083,-0.060326647,-0.099039175,-0.054582838,0.017724877,-0.021719733,0.044397887,-0.052815072,-0.013247802,0.044231214,0.12530287,0.030389557 +2.5.1.139,"The enzyme from parsley (Petroselinum crispum) is specific for umbelliferone and prenyl diphosphate. A minor product is osthenol, which is produced by transfer of the prenyl group to C-8 of umbelliferone.",384,1.0,-0.059355877,-0.093364954,-0.04042883,-0.05611715,0.06051542,0.043007396,-0.049887713,0.025528759,0.07344631,-0.06690282,0.081974566,0.016358873,-0.04361881,-0.03250834,-0.057243403,0.04019522,0.021924024,0.06968014,-0.04176833,-0.09496633,0.041641787,-0.004917712,0.017840214,-0.013663071,0.08991014,0.005610645,-0.037070822,0.05664378,0.002752485,-0.024083385,-0.0053764926,0.0044226977,0.021425378,-0.06912401,-0.03432585,0.102777675,-0.025893591,-0.07724838,0.023485152,0.047115177,0.05130724,-0.03968111,-0.059047885,0.013505093,-0.05369612,-0.0077848965,0.008510626,0.074761294,-0.049315553,0.0044219117,-0.008372705,-0.01114751,-0.07090519,-0.07160562,-0.05551877,0.016782647,-0.07547121,0.0019502786,-0.08572097,0.07029551,-0.01984697,-0.03519131,-0.048220113,-0.016682979,-0.020727923,0.04503452,-0.052956093,-0.07119853,0.05125967,-0.07804693,-0.013247039,-0.08179089,0.043766547,0.034146044,0.055100936,0.0199069,-0.04835831,-0.012283817,0.05439425,-0.035425555,-0.0028603757,0.047598902,-0.06818217,0.06578593,0.053901207,0.036004808,0.014391778,0.05943662,0.033457555,0.08889166,0.056876343,-0.015401457,-0.05285002,0.048552368,-0.08977103,0.08476879,0.001376225,-0.03227843,-0.035371177,-0.023590416,-0.013479916,-0.030670768,0.054224193,-0.079827905,-0.014625502,-0.009614752,-0.05146481,0.0015686179,-0.06461244,-0.039831493,0.014509667,0.04806074,-0.031000145,-0.025580144,0.032745674,0.015816178,0.029712226,-0.12059008,-0.07183415,-0.03855777,-0.0620629,0.018850805,-0.03413692,0.09098718,-0.033854473,0.04860023,-0.08702457,3.2975798e-33,0.0025725467,0.050130814,0.0011961025,-0.015398616,-0.03850917,0.006056612,-0.048887063,0.07747033,-0.044981286,0.043396015,-0.101385295,-0.029639231,-0.00692199,-0.054240573,0.013575742,-0.059255835,0.055791635,0.022393744,0.09914511,0.0041600214,0.022660216,0.10774744,-0.08952545,0.01515811,-0.0071915057,0.011711538,-0.029852366,-0.04788133,0.058775067,0.0068958597,0.017347688,-0.12648988,-0.017542435,-0.082973674,-0.046176113,-0.035108194,-0.053035002,-0.06824095,-0.017708998,0.06105212,-0.0011170338,0.06842527,0.0060014087,0.025984168,-0.00076797634,-0.1022397,-0.06809136,0.15736309,0.073969044,-0.008314046,0.09113258,0.030617714,0.16399306,-0.011240152,-0.070576824,0.07071105,-0.009406022,0.06692517,0.03237957,0.02825141,-0.0012186882,0.03513137,-0.033834696,-0.01609286,0.028417818,0.017300004,-0.022437448,-0.004711321,0.0019965956,0.05803876,-0.015000784,-0.02489358,-0.021464298,0.009267731,0.1174091,-0.046309285,-0.015507381,0.05941316,0.0583101,-0.008918595,0.049818046,0.0768131,-0.013013618,-0.01054986,-0.10974379,0.019600961,-0.011578792,0.041691575,0.014769988,0.05818715,0.011541258,-0.034408882,0.015743114,0.02030366,0.04242763,-3.0374805e-33,0.018193578,-0.14898255,0.028949978,0.002197353,0.01934089,0.051614236,-0.010192575,-0.021221155,-0.02098488,0.09307657,0.07084116,-0.032910418,0.004390144,-0.042624146,-0.06757877,0.058293585,-0.030767689,0.094109684,0.021447595,-0.03488097,-0.08468636,0.09798405,0.054872982,0.03413294,-0.008255235,0.006645891,0.023036787,0.023380058,-0.013243137,0.054763656,0.029419143,-0.0025210797,-0.0048776786,-0.034547545,-0.05512895,0.0146323005,-0.011240812,-0.0050568455,-0.04105515,0.0062143244,-0.023400584,-0.031369183,0.06848827,0.092038915,-0.012394174,0.017321674,-0.059279382,0.03981726,-0.056547657,0.02077465,-0.035020046,0.05198247,0.0034853665,0.016540533,0.030551765,0.050877027,0.03800426,-0.08390323,0.00048902736,-0.047236785,-0.027731383,-0.08752586,-0.007840226,0.049165577,0.094202064,0.074626796,-0.07303461,0.058706965,-0.0028511763,-0.043932784,0.06789728,0.066143155,-0.005348135,-0.015588873,0.02546709,0.007193171,0.072310336,0.036977835,0.0077491505,-0.02372332,-0.009215649,-0.02085675,-0.040918376,-0.024394777,-0.08327967,-0.061339293,0.06971879,0.087062694,-0.013114126,0.049433224,-0.034188967,0.017324187,-0.048866972,0.02634106,0.11550696,-3.334269e-08,-0.026630854,-0.038410354,0.053502552,-0.022947337,-0.009570484,0.022765378,-0.0042109154,0.013615327,0.01802004,-0.01823883,-0.02129338,0.03918622,-0.03755916,-0.026880749,0.046156343,0.001257557,0.015510237,0.014479177,-0.014188285,0.006591591,0.012421544,0.061914805,-0.04770675,-0.018038293,0.06474628,-0.07661596,0.014309565,0.044517767,-0.02832959,0.04268919,0.06362081,-0.02172044,-0.050036687,-0.05162858,-0.047701005,0.0578654,0.0004269428,-0.030556668,-0.039198127,-0.008775597,-0.055546608,-0.0887892,-0.030086635,0.0027997259,-0.006608446,0.022417892,0.012668125,-0.03684444,0.029109398,0.047452684,-0.018884793,-0.011667887,0.021115704,-0.08630062,-0.099436544,0.010924757,0.046924207,-0.08144534,0.0031609903,-0.096737705,-0.024298698,0.054394267,0.20543423,0.03133337 +2.6.1.111,"The enzyme, found in bacteria, is part of a L-lysine degradation pathway. The enzyme is also active with other beta-amino compounds such as 3-amino-5-methylhexanoyl-CoA and 3-amino-3-phenylpropanoyl-CoA.",384,1.0,-0.0409753,-0.12433241,-0.04976595,-0.016064111,0.16666652,0.06652749,-0.075167194,0.023148792,0.03160577,0.019123198,0.021228656,0.009432051,-0.010062481,0.07118702,-0.012889936,0.08340078,-0.13906844,-0.042274293,0.0015722986,-0.010480417,0.042152464,0.105013065,-0.040315673,0.007764735,0.07875085,-0.028376633,0.061578523,-0.06858395,-0.0077628368,-0.027643852,0.014005174,-0.03123773,0.054385282,-0.06755801,0.043769747,0.07712172,-0.047741387,-0.10728967,0.118646845,0.03903199,-0.01170655,-0.0050898297,-0.008487382,-0.061057713,-0.02033105,0.03022984,-0.013636747,0.0107633555,0.036729645,0.0036212297,-0.03343559,-0.07019677,-0.0076501435,0.04813275,-0.06835142,-0.026471857,-0.04371262,0.0002549048,-0.03048515,0.05737047,0.045758348,0.08738873,0.017575882,-0.001151071,0.018937705,-0.060474366,0.010043839,-0.059276495,0.035842944,-0.038919114,-0.057229593,-0.106466696,0.010289108,0.052127138,0.03692362,-0.007027204,0.062715754,-0.004944357,0.018363848,-0.063552015,-0.015485262,-0.039443903,0.018607214,0.08059509,0.0037938654,-0.028760679,0.0021931708,0.022401154,0.0499382,-0.030090054,0.026433256,-0.021368263,-0.038305197,-0.04038942,-0.017720675,-0.0035139266,0.006297259,-0.00012280226,0.04177617,-0.01089459,-0.05571562,0.049789406,-0.022455275,-0.05992764,-0.0641773,0.034066804,0.04994659,0.08364174,0.02689814,-0.05360494,0.019117346,0.034697935,0.07057287,0.016920488,0.003064906,0.0084325215,0.043056007,-0.04753001,-0.088584945,0.036704462,0.014175663,-0.059394035,0.08378305,0.054931026,-0.03555793,0.073391624,-0.09453653,-1.31009295e-33,0.06259501,-0.008899578,0.007331557,-0.06379593,0.03152137,-0.00828415,-0.050351847,0.008728268,0.012149781,-0.054621875,-0.029642988,-0.07240929,0.01937161,0.022787225,-0.003372322,0.034310345,0.0027594701,-0.019413115,0.058943607,0.04417865,-0.022543378,0.004182788,-0.002713889,0.017425988,0.05814769,0.06957418,0.077458434,0.04786534,-0.010575839,0.0077672936,-0.049446013,-0.10321989,-0.100572556,-0.00020091826,0.05484882,-0.0011358144,-0.051012546,-0.022732282,0.01058935,0.044226147,0.057436,0.04144607,-0.014147618,0.010048847,0.029050289,-0.0057307314,-0.024806503,0.105087474,-0.029148081,0.016661055,0.079861276,-0.064188816,0.058323123,-0.08799673,-0.047594592,0.0428009,-0.02784395,0.00073024613,0.031305354,0.0136506595,0.056323905,0.052569564,-0.011531158,0.040017284,0.03357709,0.024477754,-0.024927957,-0.058605835,0.010563275,0.011579705,-0.08443765,-0.026184976,0.07404174,0.031239942,0.028230386,-0.07527554,-0.10583322,0.0017165393,0.06930201,-0.043586206,0.01716322,-0.07946709,-0.009462793,-0.0059049297,-0.0076878476,-0.0065051387,0.032942798,-0.10777382,-0.040060177,0.01075318,0.03780503,-0.095555715,-0.016033197,0.049829036,-0.00073343876,-6.6966494e-34,0.05730963,-0.110908896,0.013106261,-0.08140609,-0.06836146,0.005715282,0.011782759,-0.014134083,0.032028724,0.016058194,0.0759358,-0.011793559,-0.047301307,-0.051392548,0.054932125,0.041102417,0.029746171,-0.0085091,-0.028237313,-0.03847719,0.031931322,0.008653988,0.04098715,-0.04853699,0.03817805,0.021888165,-0.064046174,0.09875581,0.052686017,0.0085674,-0.035951253,0.013298802,0.022940716,-0.102791585,-0.033017125,0.021085098,-0.03913899,-0.042268712,0.068707295,-0.056968458,0.06061435,0.012000694,0.0321324,0.036880847,0.016996723,0.057340346,-0.055907372,-0.024234772,-0.009548659,-0.07181692,0.02967555,-0.08266679,0.0101032965,0.016457608,-0.019356076,0.079708025,-0.04776409,0.08512893,-0.055856753,-0.00341412,-0.06325845,-0.03749306,0.021784168,0.09493694,0.059680384,0.02456689,-0.0092673665,0.0731745,0.03959083,-0.04400167,0.101158,0.025932154,0.059482478,0.07255204,-0.09245544,0.004777037,-0.10955859,-0.07496839,0.018317875,-0.017651832,-0.021615451,-0.048280977,-0.041196514,-0.057068836,-0.03760998,-0.09905588,-0.025662763,0.15463448,0.071010984,-0.01022849,-0.014631585,-0.036949813,-0.03659573,0.009625728,0.0987221,-3.7121964e-08,0.03462716,-0.040501103,0.019765247,-0.03238628,0.0241461,0.00038969598,0.01419306,0.051920198,0.062125485,0.014953666,-0.041633144,0.06411363,-0.05640789,-0.04601012,-0.0077232053,0.02203744,-0.06537147,0.034386277,-0.021629557,0.019707153,-0.04857009,-0.015226154,-0.02910214,0.053938057,0.028431023,-0.06224279,0.01703979,0.020400792,-0.028922182,-0.050481178,-0.011932744,0.03379654,0.026784662,-0.03125509,-0.10574834,0.01809247,-0.042054005,-0.06188085,0.0008984139,0.08414804,0.02217429,0.054643005,-0.10863778,-0.023033455,0.042385414,0.04341409,0.016623056,0.04180466,-0.027309276,-0.051479716,0.019380452,-0.023531817,-0.06926837,0.0010139926,-0.08791871,-0.009322802,-0.03999506,-0.02081116,0.03665582,-0.079623684,-0.026904082,0.04873625,0.20890589,-0.01463676 +2.6.1.112,"A pyridoxal 5'-phosphate protein. The protein, found in bacteria, can use other amino-group acceptors, but is specific for (S)-ureidoglycine.",384,1.0,-0.07090659,-0.093135424,-0.030930128,-0.07925602,0.031764302,0.05862654,0.00021870348,0.021668226,0.097127035,0.031006007,0.04344728,0.0592546,-0.034147315,0.14233619,-0.032039214,0.009135751,-0.03304045,0.036788262,0.039511085,-0.047027346,0.07069179,0.058134004,-0.040657997,-0.048007123,-0.034198,0.0402267,0.027549164,0.04052745,-0.00533933,-0.06105174,-0.01708928,-0.024801785,-0.034883976,-0.08927802,0.030773196,0.079358704,-0.08574953,-0.023670478,0.09021239,0.0066474723,0.061804537,-0.036106665,0.021756275,-0.015131505,-0.067312226,0.015494408,0.027178774,0.037391227,0.070779845,-0.040884767,-0.06928212,-0.010420639,-0.02690282,-0.0063625365,0.00017553108,-0.021048175,-0.0322771,-0.021721361,-0.041589204,-0.1187543,0.00793945,-0.016962245,0.08957775,-0.015888667,0.0051224306,-0.033255916,-0.043151833,-0.019604396,0.007571841,-0.0040547405,-0.012745656,-0.026306553,0.09200327,0.07929964,-0.035975616,0.034944337,-0.029669862,-0.027998768,0.037601896,-0.017374663,-0.018515218,-0.01917618,0.011388742,0.09175089,0.07933053,0.025848133,-0.007359412,0.045507837,-0.029480182,-0.032070074,0.03657282,-0.04505625,0.046266507,-0.078652866,0.002597474,-0.049268495,-0.04150083,-0.06369773,-0.035385486,-0.053109564,-0.019779237,0.028910818,-0.0010249084,-0.05940953,-0.041417055,0.0067411163,-0.04881508,0.07166764,0.011226553,-0.018935917,-0.08131526,0.026496582,0.0031362849,-0.01898918,0.022371598,0.011631081,0.034497634,-0.037322424,-0.060137395,-0.008410803,-0.02724657,-0.016133696,0.0020545756,0.08748438,-0.040196262,0.009294033,-0.10174722,-1.1803087e-33,0.04236226,0.05090935,0.030887684,0.007945582,-0.00013648823,0.006209038,-0.043826193,0.002210594,0.0068791397,-0.07658406,-0.07492453,-0.030045804,0.05092145,0.0027409035,-0.05827159,0.035003502,-0.05652607,0.03722601,0.08941852,-0.03428034,0.036572203,0.11321806,0.054808363,0.00790827,0.051784363,0.030897776,0.017057735,-0.045310225,0.009099254,-0.0023743005,5.784638e-05,-0.065124415,-0.124059595,-0.028488519,0.080937795,-0.0591656,0.0094568,-0.058524452,-0.026026899,-0.006655353,0.031294435,-0.017020699,-0.036997855,0.07078809,0.05466373,-0.04833377,-0.07389346,0.031577654,-0.07448588,0.013898379,0.045907967,-0.06518919,0.069089174,-0.06020673,-0.12223194,-0.054897886,-0.00984232,-0.0006460086,0.0082495045,0.08199164,0.049525186,0.04283951,-0.031300444,-0.026080217,0.0077095195,-0.007012183,0.0315261,-0.06361616,0.03185764,0.08118023,0.012691336,-0.020156091,0.06632722,0.05503025,-0.018818034,-0.08649873,-0.061019007,0.015647935,0.0549858,0.052711867,-0.018857494,-0.09289666,-0.071505606,0.013133651,-0.08434742,-0.004163804,0.06771693,-0.09343642,0.0019967894,-0.02320901,0.088470645,-0.099794164,-0.07245899,0.074776635,-0.020783741,-3.8798867e-34,0.10190456,-0.11782909,0.0984905,0.035036698,-0.037722558,0.03363948,0.083995596,-0.0030934373,0.07008702,0.02240616,0.07131772,0.0012578378,0.012822502,-0.06702273,0.0007959111,0.06504859,-0.052269388,-0.012053316,0.026315385,-0.0010125954,-0.03525601,-0.012248123,0.005853305,0.072902255,0.03248838,0.114796266,-0.035452172,-0.006317949,-0.014771688,-0.021124618,-0.003861522,0.019906348,-0.029718444,-0.12329727,-0.06603704,0.033576228,-0.07674418,0.026372414,-0.0455244,-0.05311134,0.081818104,0.057065472,0.0030806616,0.07589086,0.015339899,0.04533848,-0.022269102,-0.0016089733,0.010190052,-0.03780495,0.062869966,-0.025119666,0.011841298,-0.01828269,0.027445162,0.019231852,-0.06302088,0.04121014,-0.0062004593,0.061967745,-0.0075275265,-0.067249894,0.02345394,0.09314765,0.01954349,0.037528187,0.012174758,0.0033668028,0.0702074,-0.004323603,0.030523613,0.004676116,0.1108603,0.06637864,0.028516391,0.05217234,-0.04965592,0.033603467,0.051747367,0.021353392,-0.07756056,-0.026261363,-0.054509338,-0.0018121381,0.06765611,-0.025109235,0.091054745,0.10824509,0.022966078,-0.012390162,-0.020350112,0.023994353,0.0074087307,0.062236037,0.08338208,-3.1636784e-08,0.08952544,-0.04922431,0.03934692,-0.038660508,0.00023018659,0.01542162,-0.002715474,0.01021439,0.077977076,0.02814553,0.0032526117,-0.01954609,-0.037565783,-0.009130601,0.043159347,0.09032437,-0.055573367,0.008694994,0.021469362,-0.02978898,-0.06778593,0.03528422,-0.09178891,-0.02262979,0.04406421,-0.016856235,-0.041709967,-0.032946017,-0.06405361,-0.042813145,0.02349159,-0.016809866,-0.04793828,-0.019053586,-0.026876716,0.109564565,-0.04993881,-0.053758763,-0.002962668,0.020621695,-0.040057383,0.029620651,-0.050677463,-0.04597232,0.020278739,0.05726647,-0.04331947,0.034888975,-0.108246945,-0.018118642,0.026604475,0.001581057,-0.06258515,-0.093010455,-0.14424238,0.037971567,-0.004875903,-0.10705536,0.00039567344,-0.06893593,0.012775253,-0.0349529,0.10662936,0.027071062 +2.7.1.216,"The enzyme, found in plants and animals, can also use other nucleotide triphosphates as phosphate donor, albeit less efficiently. The plant enzyme can also use geraniol and geranylgeraniol as substrates with lower activity, but not farnesyl phosphate (cf. EC 2.7.4.32, farnesyl phosphate kinase) [2].",384,0.99999994,-0.073391914,-0.009517164,-0.023384044,-0.072926365,0.036681656,0.038592573,-0.05750466,0.028250659,0.060786206,0.013677057,0.016792927,0.027948936,-0.11157744,0.06085226,0.010715723,0.032645687,-0.033888407,0.12986366,0.05833809,-0.008636374,0.05720863,0.0006175936,-0.025895394,-0.021561593,0.0655549,-0.019089295,0.019197693,-0.02746674,0.021163238,-0.023775468,-0.07153377,-0.031877235,0.013734148,-0.047670905,-0.0461464,0.14790331,-0.05592246,-0.07386146,-0.0012265821,0.048474386,0.05462806,-0.033600282,0.030623037,0.02599437,-0.07949694,-0.035372037,0.0025576286,-0.003969591,-0.004166122,-0.013419144,-0.06017946,-0.017319264,-0.004583871,-0.09533687,-0.032128397,-0.00021780448,0.027472625,0.039351653,-0.046447173,0.059681147,0.040816292,-0.030929184,0.011191413,-0.050823398,0.04266584,-0.025068877,0.007087688,-0.023407096,0.04138971,-0.04293976,-0.018420493,-0.043778084,0.0554571,0.020602522,-0.07566751,0.057023175,-0.06420318,0.071298614,0.050472803,-0.015240754,0.029374458,-0.012523602,-0.025282845,0.014061016,0.065688714,0.066667214,-0.10932491,0.114285775,0.006553868,-0.0023182374,0.07484415,0.005236712,-0.007265907,-0.060480047,-0.03390489,0.027534353,-0.016293956,-0.008422875,-0.014833238,-0.071029656,0.061712835,0.058087118,-0.02377775,-0.080549695,-0.023612572,0.071513616,-0.07881862,-0.03705942,-0.0022360599,0.032490812,-0.06656305,0.0738507,0.028510928,0.024423834,-0.02953541,0.018296454,-0.044596765,-0.09814944,-0.059364,0.040946446,-0.034496088,-0.09480225,0.004007546,0.07947556,0.00086432806,0.032648083,-0.06424364,1.673504e-33,0.035418484,0.055949144,-0.01072853,-0.04547189,-0.06546313,0.04430918,-0.00535675,0.0114445165,-0.11297153,-0.09949088,-0.03894703,-0.046270736,0.07449308,-0.026701802,-0.0038813038,0.015548832,0.0054537724,-0.007317688,0.13700566,-0.037284058,0.06302351,-0.008479181,-0.030742977,0.058828954,0.049716722,0.011969876,-0.032362908,-0.024247607,0.060041536,-0.028674453,0.06395615,-0.13815573,-0.010987281,0.0342369,0.028757121,-0.07709921,-0.06889301,-0.06270897,-0.036973793,0.030604543,-0.023231253,0.0053314315,0.04625281,0.07553565,0.058926318,-0.04003989,-0.02022281,0.044194523,-0.010999362,0.023173697,0.027324837,-0.048441757,-0.0066174283,-0.042853907,-0.06721362,-0.009005099,0.003794765,-0.005343472,0.022277543,0.018554902,-0.014102466,0.014612195,-0.0076098926,0.0012157961,0.06457644,0.0048987675,-0.06214874,-0.05331313,-0.032252926,0.14608422,0.07026479,-0.098352194,-0.0067276154,0.036406577,-0.028278053,-0.039151676,0.021859039,0.02271626,0.01344444,0.039397974,0.047178626,-0.064798094,-0.009863297,-0.024289353,-0.03720295,-0.026015291,-0.013181079,-0.07443464,0.009250781,-0.0027674176,0.09582938,-0.11205963,-0.08182673,-0.017894967,-0.009798397,-2.1660164e-33,0.1339558,-0.039450876,0.044824485,-0.02561745,-0.062011354,0.036552336,0.079776905,-0.11744319,0.063108526,0.012446623,-0.021629466,-0.015257874,0.09440828,-0.048285566,-0.0023574615,0.014414908,0.010113064,0.03784894,-0.0008830201,-0.027420316,-0.028464206,0.10298531,0.059905373,0.022473942,0.017174887,-0.022647502,-0.059851054,0.03003679,-0.035855602,0.032954253,-0.013531144,-0.014331051,-0.038407374,-0.09195207,-0.0020459224,-0.006626823,-0.065718785,-0.0005688592,0.03086736,0.011117157,-0.009297837,0.055890657,0.0670955,0.034406204,-0.041058946,0.06403996,-0.04713857,-0.0010179927,-0.016693838,-0.060655836,0.018088514,0.0670735,-0.05327808,0.02990168,0.042311627,0.0050081844,0.0016805755,-0.016548345,-0.02256087,-0.052443195,-0.025304008,-0.067366734,0.014975822,-0.020873632,0.0126587385,0.1191459,0.016155798,0.087695144,0.003945891,0.0013115536,0.0122544225,0.05180743,0.0781642,0.12009707,-0.0844772,0.07052279,-0.017036,0.010497768,-0.01045381,-0.040117826,0.018723179,0.013473357,-0.06047421,-0.048055857,0.037107777,-0.03771928,0.046438426,0.096636534,0.026419131,0.030155722,-0.015744023,-0.006895765,0.02590678,0.038462114,0.1503168,-3.7801545e-08,-0.019150335,-0.02023782,0.07303699,-0.08657984,-0.0076547093,-0.043523464,0.023726137,0.06470628,0.042169064,0.044152535,-0.0765812,0.04645574,-0.014767302,0.029262992,0.11388015,-0.009828924,0.036788158,0.043783497,-0.046544656,-0.030605994,-0.026496522,0.024654912,-0.11035392,0.058829166,0.024652533,0.023881333,0.042948272,0.0026646836,0.015245178,-0.025927318,0.02553704,-0.024837751,0.010698943,-0.016243732,-0.04340513,0.054959796,-0.010964486,-0.004665765,-0.045615833,0.036386836,-0.024440618,-0.06952799,-0.055020414,0.03930131,-0.06176932,-0.0025481242,0.0047817426,-0.00376004,0.017383022,0.026090775,0.08265831,-0.049816735,-0.05396006,-0.12121324,-0.055419493,-0.0060086693,0.013595741,-0.027016824,0.02236742,-0.05271936,-0.008792866,-0.002698123,0.19579291,-0.042493876 +2.7.4.32,"The enzyme, found in plants and animals, is specific for CTP as phosphate donor. It does not use farnesol as substrate (cf. EC 2.7.1.216, farnesol kinase).",384,0.99999994,-0.08497908,-0.020066923,-0.021914057,-0.08478378,0.03400911,0.016462795,-0.07143504,0.04966559,0.043041687,-0.019036354,0.018822433,-0.037353333,-0.110978074,0.044369802,-0.04639466,0.017042203,-0.04190373,0.036301505,0.0646843,-0.0055650733,0.007141912,0.028387386,0.0023468095,-0.03259674,0.04040799,0.014146787,0.056239463,-0.035292655,0.014304388,-0.035316106,-0.08572324,0.019992067,-0.03544382,-0.032334976,0.008310282,0.15987389,-0.07956473,-0.09745948,-0.016841492,0.023540378,0.08462142,-0.033844315,0.012260008,0.03380354,-0.009580452,-0.03960925,-0.03223064,0.04608216,-0.022174034,-0.03486618,-0.04670035,-0.018625407,-0.015805319,-0.043216396,-0.08177757,0.016526686,-0.018122248,0.01795772,-0.032137744,0.040558558,0.03630567,0.009287772,0.0015689018,-0.0042894455,0.0683194,0.013965277,0.010595737,-0.048101272,0.03758198,-0.07157646,-0.06995763,-0.031999752,0.0704912,0.06270003,-0.05184347,0.036358207,-0.03333559,0.032994047,0.06624492,0.0014485433,0.026236689,0.03535232,0.003693647,0.0114254225,0.13397908,0.04558325,-0.075479,0.08970768,0.02832366,0.03860841,0.03542434,0.005227697,-0.03507327,0.012163926,-0.042365395,-0.01368734,0.0034103917,-0.0039216266,-0.053020697,-0.100433454,0.019810138,0.093061544,-0.008634858,-0.040839776,-0.043943357,0.010500706,-0.07660607,-0.04849854,0.009649692,-0.014725219,-0.040003352,0.10050196,0.062072873,-0.026494937,0.09244126,0.04081078,-0.072474785,-0.12876916,0.007767241,0.019850835,-0.09557241,-0.1005174,-0.041998986,0.07320143,-0.0051475856,-0.0142987855,-0.07208244,-2.6566024e-33,0.026365085,0.07877643,0.0067873285,-0.037295993,-0.008578057,0.0029367332,0.0057729366,-0.044924986,-0.11625521,-0.08685726,-0.060794365,-0.04193252,0.0066966005,0.0010738282,-0.017020488,0.014420798,-0.008515519,0.013007071,0.09467464,-0.07925625,0.006962078,0.051093966,-0.040691398,0.06705062,0.027574955,0.080422446,-0.09373827,0.019520653,0.027459987,-0.00094698346,0.010586526,-0.077973396,-0.022407928,0.0690958,0.006151628,-0.0011425236,-0.0762863,-0.08457764,-0.021840189,0.096629314,0.015883511,-0.018934648,0.046434253,0.057703715,0.012670196,-0.07392486,-0.07899469,0.011963236,-0.00877546,-0.011684479,0.06232324,-0.016275734,-0.029204676,-0.044948634,-0.07314444,-0.04723226,-0.039367463,0.03485083,0.02257923,0.048800893,0.024344679,0.028149134,0.01130223,0.043134753,-0.010802084,0.027521702,-0.067443416,-0.05919155,0.02094606,0.15808792,0.022465913,-0.0077710217,0.06406287,-0.011597763,0.08943831,-0.042368185,0.03875247,0.0766246,0.0149308145,0.081316315,0.041059867,-0.08381938,-0.038646445,-0.02244965,-0.058338944,-0.037794676,0.06021408,-0.019626807,0.042116046,0.06442642,0.11410463,-0.065846466,-0.053796258,-0.0059120622,-0.009457049,5.8721894e-34,0.06817088,-0.06093276,0.015539603,-0.035808474,-0.04945821,0.0097640855,0.03832185,-0.11687425,0.10507212,-0.025553856,0.07268586,-0.0024126293,0.045840047,-0.025080532,0.00067102397,0.025398588,0.024238165,0.016698733,-0.023007128,-0.0332494,-0.03686321,0.04473166,0.022270374,0.08218368,0.0109933205,0.001388354,-0.08301453,-0.0049938546,0.019883135,-0.005333316,0.002826253,0.048607074,-0.057485804,-0.019789761,-0.03303678,0.0074737165,-0.0582407,0.0065712743,0.03488844,0.011632035,0.054488223,0.015083798,-0.014276392,0.04889441,-0.06576253,0.069361456,0.058688115,-0.07426583,-0.0014219938,-0.033572584,0.061479084,0.114487685,-0.012990665,0.014229983,-0.009563727,0.09827123,-0.011131646,-0.01904989,-0.025027927,-0.061111193,-0.04790247,-0.024659563,0.0057408353,-0.010473837,0.05048638,0.0666159,0.020735731,0.09236565,0.0158661,0.020362034,0.011813207,0.094079494,0.07226108,0.08711328,-0.07410216,0.033219006,-0.04436016,0.048208408,0.01870575,-0.055549875,-0.0077127186,-0.0021654076,0.010156631,-0.049013272,-0.029337576,-0.039669078,0.03261882,0.077670716,0.035692956,0.026160048,-0.0011420251,-0.027707098,-0.061406486,0.0041094986,0.13556617,-3.029042e-08,0.012613032,-0.014738794,-0.019737424,-0.0632184,0.02462399,0.0141466465,0.04977159,0.05467266,0.025698753,0.01360385,-0.07442911,0.06933355,0.0054247165,-0.022173785,0.07662224,0.0002185749,-0.007126296,-0.042387076,-0.003797179,-0.06366624,-0.058381923,0.029850988,-0.073159926,0.031435676,-0.02714445,0.045385927,0.0091572935,0.046017133,-0.0064478805,-0.03089519,0.026226122,-0.011091726,-0.04037546,-0.021640424,-0.031769566,0.039191313,0.05732809,-0.055612557,-0.03860585,0.08082657,-0.018378502,-0.027856985,-0.06629736,0.027635396,-0.067515485,0.046502262,0.04364459,-0.0599142,0.014286615,-0.022291807,0.03688933,-0.00464021,-0.05248708,-0.11699466,-0.055444937,-0.0052849804,0.009541961,-0.044104703,-0.035518136,-0.09700857,-0.035318423,0.013154854,0.18819593,-0.036710005 +2.7.7.98,"This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase.",384,0.99999994,-0.045354474,-0.03279164,-0.0927889,-0.013593988,0.0057822624,0.0010350242,0.018095838,0.039127406,0.040365342,-0.0010142368,0.0075524882,-0.11398907,-0.014202238,-0.008727936,-0.04457891,0.07838171,-0.048338704,0.023435656,-0.053147938,-0.08379338,0.035936255,0.053918846,0.013851226,-0.013790724,0.034812175,-0.0031078674,0.07576942,0.019584278,-0.019701041,-0.084979296,0.0032068247,-0.10341739,0.028880524,-0.014964731,0.06966009,0.12021973,-0.02572338,-0.1559684,0.09828216,0.047434498,0.08785938,-0.046677213,-0.025590414,0.013126819,-0.027105032,0.035302415,-0.050578676,0.05994723,0.008990735,-0.038957432,-0.06101862,-0.008445799,-0.030363286,0.022171384,0.00047586515,0.08096679,0.014745054,-0.0376034,-0.0012310644,0.042499386,0.047939822,-0.012923437,0.002132286,0.054787584,-0.050607637,-0.07715059,0.0073910635,-0.041751917,0.038768314,-0.04202059,-0.10018834,-0.042834893,0.010101682,0.04805367,0.054141786,-0.05908953,0.00015139034,-0.02917264,0.027654452,-0.0068125473,-0.012269538,-0.04319288,-0.031226013,-0.03896291,0.031519018,-0.08580927,0.12083993,-0.014785261,0.005166969,0.098820016,0.040244434,-0.110151775,0.041366406,-0.052365057,-0.058551293,-0.0052024988,0.13644877,0.0016810123,0.023697704,-0.03145154,0.0049642,0.0043459227,-0.025040017,-0.027878597,-0.057066623,-0.005419343,-0.031652387,0.08853918,0.02320146,0.032377414,-0.03884565,0.00715259,-0.014778169,-0.008824856,0.015066919,0.13847902,0.0077915452,-0.06305213,-0.024167662,0.01975507,-0.012282167,-0.06782572,-0.01605713,0.062094774,-0.12444225,0.016549641,-0.11564051,8.409472e-34,0.045752984,0.017845184,0.0026270247,0.012120844,0.019935252,-0.012570681,-0.14183873,0.005454545,-0.028414892,-0.15273973,-0.025333926,-0.051733866,0.012712148,0.05349718,-0.093031116,0.014756478,-0.09978515,0.033138912,0.084737144,0.08807866,-0.0004702198,-0.024942217,-0.036759626,0.0312525,-0.013954259,0.063053355,-0.069264464,0.0030220656,0.030741615,0.03478574,0.009421838,-0.051379483,-0.06650033,-0.013735865,0.0038526468,-0.027706174,-0.0077396315,-0.114091374,0.051658493,0.034732815,-0.015161895,-0.049113728,0.025858713,-0.024405496,0.048495848,-0.03597587,-0.006989598,0.058824286,0.0020563502,0.061645813,0.024802133,-0.08844126,0.122502476,-0.038612794,-0.018925058,-0.04018351,-0.07390481,-0.054416094,-0.0063159205,0.02506398,0.032778855,0.09726527,-0.012118345,0.06685319,-0.04270858,-0.028129786,-0.027816098,0.0059833066,0.010163463,0.06616266,-0.038318653,0.005806841,0.053934675,0.008450858,0.06655932,-0.017578539,-0.11163252,-0.005056738,-0.04731005,0.009443953,0.037284125,0.028757725,0.010864688,-0.031659354,0.018908435,-0.028806334,-0.04095741,-0.036373276,-0.019248687,0.043336958,0.033173863,-0.07965552,-0.022060487,0.07782285,0.01348607,-3.591151e-33,0.11785304,-0.11981541,0.036513917,-0.06836436,-0.03914871,-0.018998256,0.060476463,0.054505404,0.024096796,0.022935696,0.06668845,0.022610962,0.02192769,-0.075204454,0.018947903,-0.042433485,-0.005906343,0.031273544,-0.027013374,-0.02336992,0.03647259,0.016935438,0.039851397,0.026890682,0.025629526,-0.014691685,-0.0751418,0.07098101,0.043870702,0.048165824,-0.031706955,-0.015947208,-0.037574716,-0.020070424,-0.016304431,0.01638367,-0.06891592,-0.0008798362,0.044986192,0.022001406,0.051873755,0.051065408,-0.03548006,0.025397923,-0.0048208702,0.09174041,-0.03699573,0.03752496,0.020199392,-0.106429726,-0.03447889,0.045640606,0.0167428,0.037574492,0.0013712171,0.1095355,0.02773102,0.01860853,0.029259354,-0.040559612,-0.09034639,-0.036527373,0.05018026,-0.013311141,0.031578086,0.049036123,-0.0045983153,0.10603443,0.06788164,-0.004663113,0.059210014,0.006366722,-0.032087564,0.0033778558,-0.04085645,-0.06180384,-0.04433558,0.0018257425,-0.018060965,-0.008565362,0.021807367,-0.023487788,0.018370902,-0.116284974,-0.011730662,-0.048422247,0.05087026,0.110684894,-0.044437665,0.025558487,0.025262436,0.09672686,-0.079150155,0.0018695988,0.037647184,-3.5779042e-08,0.012032502,-0.07171016,0.076052144,-0.021742495,0.074559055,0.04812996,-0.04172465,-0.0054852962,0.044625506,-0.0058565103,-0.02620466,0.040924914,0.06564943,-0.00069118035,0.052234136,0.038428076,-0.03944697,-0.023998296,0.036249675,-0.041402053,-0.08051193,-0.03667318,-0.024911566,0.065765955,0.022225909,-0.007169647,0.057147894,0.06431264,0.0057098563,-0.0109704435,0.017579518,0.017878424,-0.058022484,0.021758465,-0.08106962,0.009943925,-0.08312427,-0.082547754,-0.028923308,-0.024242323,0.0459441,0.008356634,-0.043514725,0.052282933,0.03515692,0.08147011,-0.006962523,-0.010201869,0.020125259,0.021531567,0.005008815,-0.034500707,-0.00013856967,-0.013273236,-0.046266444,0.008568544,-0.041321546,-0.036808353,-0.027577499,-0.017485429,0.0068412223,0.06544242,0.15410514,-0.047216404 +2.7.8.45,"Involved in the biosynthesis of teichoic acid linkage units in the cell walls of some bacteria such as Staphylococcus aureus. This enzyme adds a second glycerol unit to the disaccharide linker of the teichoic acid. cf. EC 2.7.8.12, teichoic acid poly(glycerol phosphate) polymerase.",384,1.0,-0.016743695,-0.063550316,-0.118414536,-0.026839312,0.012890244,0.08604121,-0.09592411,0.07221124,0.058166023,-0.056597687,0.08602094,-0.066835746,-0.0058973376,0.036341634,-0.08713897,-0.086399645,-0.026883535,0.019853001,-0.035460543,-0.06878603,0.026719164,0.058829937,-0.03883005,-0.018627474,-0.004590424,-4.8174687e-05,0.0034614846,-0.04331791,0.025709156,-0.029895596,0.00081687653,-0.06926722,0.059205536,-0.07149031,0.040046375,0.07857224,-0.038385667,-0.0019758262,0.06277013,0.038751055,0.047386877,0.0065778536,0.030981816,-0.028446782,0.0026399838,0.029776283,0.019982874,0.04599574,-0.021565504,-0.0054269247,-0.04999292,0.04804745,-0.06869645,0.005870793,0.0026212886,0.059216753,0.024189895,0.018893523,-0.01687184,-0.008895166,0.01434532,-0.00803724,0.056055937,-0.0154131865,-0.035933185,-0.068379276,0.073183,-0.00096556236,-0.011410836,0.026871057,-0.022833513,0.039036825,0.06561046,0.013162326,-0.017969068,0.052349363,-0.058721244,-0.035176296,0.020307165,-0.013713642,0.0144758,-0.05367303,-0.06915603,0.07484056,-0.03292957,-0.018913079,-0.007431249,-0.06367545,0.035138987,0.06387342,0.09606507,0.0018822381,0.013122835,-0.073975876,-0.056531865,0.0023607586,-0.024612194,-0.04123084,0.035304237,-0.092890576,-0.07293616,0.021803312,-0.010836813,-0.051821172,-0.03841094,-0.01592759,-0.049766023,0.07282032,0.031903245,0.045184344,0.05454268,0.010440795,0.027122548,-0.026019434,0.0022314664,0.04455255,0.06026756,-0.12459041,-0.019949783,-0.033430595,0.010573846,-0.06692502,0.047603313,0.037046246,-0.025180519,-0.027655313,-0.0022535643,2.6335588e-33,0.105547085,0.054109357,-0.021032285,-0.06439674,0.022460707,-0.006423892,-0.11713377,-0.035087846,-0.051738847,-0.026457058,-0.06681669,-0.026498083,0.0044717165,0.019818852,0.017132986,0.04383799,0.005434808,0.03959133,0.036097117,-0.040232703,-0.009363346,0.08002982,0.02753734,-0.013608975,0.044349726,0.09821915,0.0065749325,-0.040851694,-0.009924253,-0.00891281,0.029582579,-0.020080257,-0.101926535,0.023695374,0.18941155,0.0404532,-0.11132745,-0.011365109,0.059392706,-0.0044563427,0.023800332,0.048834454,0.08100673,-0.031377845,0.06278619,0.0019692043,-0.0099207815,0.04556075,0.013633139,0.016686164,0.0596081,0.025767222,0.07826624,0.014284227,-0.05477909,-0.0037453678,-0.05180454,0.024427708,-0.030555762,0.08947216,-0.0070427046,0.053841952,-0.051596962,0.016639994,-0.02461336,-0.013379346,-0.047860913,-0.017254895,0.06727414,-0.03212496,-0.019034322,-0.07943917,0.08353872,0.04240311,-0.06360011,0.0125531955,-0.046598643,-0.02625605,0.020039076,-0.06879927,-0.06379857,-0.0014203958,-0.033862367,-0.05508383,-0.054723658,0.017564,-0.005524285,-0.030484084,-0.034739293,0.006691963,0.04460086,-0.0747956,-0.0045697535,0.10935042,-0.017875487,-5.151593e-33,0.08654897,-0.13772748,0.109484494,-0.09181339,-0.03794032,0.01784835,-0.01838302,0.012098882,0.0075023645,0.022563849,0.06253828,0.038464263,0.061113816,0.016328009,-0.023303133,0.033860505,0.067134246,0.10839087,-0.056628328,-0.121277325,0.039304934,-0.033220965,0.02532552,0.02696826,0.044455238,0.07984258,-0.0129866665,0.01079065,-0.00454303,0.029180948,-0.0057014152,0.019275935,-0.10117122,-0.027585804,-0.049191244,0.039740644,-0.011401495,0.010901984,0.09833222,-0.034514215,0.11312963,0.026092462,0.057949375,-0.0014200872,0.07262388,0.08514319,-0.009590308,-0.033651773,-0.06684109,-0.04026865,0.020090938,0.013339234,-0.0042935805,0.00820993,0.01982705,0.05777846,0.032286547,0.031132257,-0.05209384,-0.06409681,-0.018644614,-0.10346274,0.01203183,0.017162764,-0.0233342,0.011571846,0.045675877,0.0076507493,0.07705848,-0.017303323,0.011872296,0.06048701,0.008456255,0.0008676854,-0.047727108,-0.058066677,-0.112971924,-0.07268622,0.029453635,-0.02179132,-0.022955554,0.016880568,0.023979705,-0.042026505,0.04591354,-0.08261759,0.054011434,0.1172409,0.0056585358,0.05026715,-0.070155844,0.014830902,-0.04848178,0.025408998,0.058783453,-3.8371876e-08,0.061442874,-0.061145697,0.031022554,-0.07877698,-0.035428863,-0.005155024,-0.037699837,0.046674453,0.028067272,-0.01627219,-0.03840063,0.014055801,-0.05376918,-0.008145878,-0.026547888,0.08754645,-0.09772309,-0.094424255,-0.020600986,-0.08411053,-0.044280294,-0.0017353888,-0.087300405,0.10260695,-0.029189741,-0.027576279,-0.041814826,0.00152472,-0.06277883,-0.0059074084,0.06093273,-0.0051427456,-0.040094562,-0.012477027,-0.008769143,0.016446361,0.022491764,-0.078344904,-0.01663036,0.030687552,0.006657416,0.009594513,-0.09429095,0.060815595,0.06903985,0.05126117,-0.020786248,0.05883237,-0.06412957,0.007180397,0.013290995,0.003491046,-0.024557926,-0.052845117,-0.12551667,-0.039810006,-0.020825839,-0.074155554,-0.022290591,0.041903898,0.0014645372,0.023760565,0.14017026,-0.052100856 +2.7.8.46,Involved in the biosynthesis of teichoic acid linkage units in the cell wall of Bacillus subtilis W23. This enzyme adds the first ribitol unit to the disaccharide linker of the teichoic acid.,384,1.0,-0.026827456,-0.05693114,-0.074216045,-0.044626396,-0.006382717,0.058505755,-0.122702755,0.053109765,0.070137314,-0.0672292,0.08282341,-0.11061236,0.07979171,0.016596695,-0.07712728,-0.020006211,-0.039694518,0.016500099,-0.04912227,-0.06768966,0.02571965,0.08736176,-0.02712054,-0.005504086,0.018326346,-0.05471219,0.032527477,-0.054930385,-0.00084012834,-0.011322292,-0.013024185,-0.050630346,0.055429775,-0.07338128,0.0255811,0.04508205,-0.0015699886,0.007480772,0.16236901,0.041309442,-0.008970002,0.013934676,-0.0054168375,-0.0048891283,0.0070033036,0.031903427,0.005010937,0.059015878,-0.02098968,0.028404946,-0.0724251,0.06429959,-0.047177695,0.041367088,0.047140222,0.040434353,0.03343393,0.004973855,0.028166078,-0.00083187915,0.005178746,-0.05381639,0.0334847,-0.055724707,0.0025509642,-0.06244448,0.018767495,0.013160969,-0.0019765208,-0.028718328,-0.023399986,0.024286067,0.01661304,0.032458816,0.020381292,0.06471153,-0.034241535,-0.0008402297,-0.009350821,-0.041194204,0.0118805915,-0.03004022,-0.045411807,0.10383596,0.02030625,-0.041097645,0.007195347,-0.04605954,0.05366293,0.06317662,0.028628837,-0.0014821637,0.00076875684,-0.05917031,-0.02016509,-0.030261833,-0.042339776,-0.036634494,0.013638506,-0.08677485,-0.044991314,0.031050965,0.021792842,-0.020055067,-0.08489978,-0.034493547,0.005174242,0.14846337,0.013311702,0.0455955,0.10115627,-0.020999735,0.008824684,-0.07144976,0.013090128,0.0356276,0.042701084,-0.11026818,-0.02090857,-0.07291672,0.051368363,0.017429402,0.034237675,0.020347947,-0.05510901,-0.039973337,-0.0032500897,3.6906992e-33,0.112441644,-0.007088713,-0.027237868,0.022725442,0.015990824,0.005509544,-0.12818739,-0.033437412,-0.021363381,-0.020485433,-0.14492457,-0.09396552,-0.0063509163,0.008388824,-0.007032247,0.028159142,-0.001783341,-0.025589313,-0.012077726,0.007305548,-0.018012801,0.10259244,0.0086229015,-0.0020166591,0.034034315,0.048590735,0.03570943,-0.066748485,-0.025612172,-0.020307954,0.041361067,0.0013209219,-0.10536561,-0.009564468,0.09205611,0.038508523,-0.058934335,0.020728152,0.0014635549,-0.0069307284,0.023178557,0.07849722,0.03757319,-0.055111118,0.09940067,0.020365298,0.04395899,0.060968734,-0.011223512,0.042145543,0.043012038,0.05654843,0.10243329,-0.014502933,-0.022058595,-0.012358609,-0.011020716,0.042101096,-0.031178799,0.084636316,-0.01935946,0.008254322,-0.0035152636,0.11934366,-0.0620015,-0.013245882,-0.0669349,-0.021301432,0.027685903,-0.018110503,-0.060433928,-0.024036255,0.08199534,0.00452253,-0.0929994,-0.008610027,-0.05586858,-0.042309012,-0.018976044,-0.056451585,-0.020572642,-0.020198615,-0.020039761,-0.03523892,-0.028493345,0.04887449,-0.0004685138,-0.05672049,-0.0048783827,0.0266199,0.075668946,-0.07037821,-0.048219625,0.12297453,0.036831744,-4.443199e-33,0.12908888,-0.09924785,0.097144105,-0.12405237,-0.0908907,-0.0033417752,-0.038121544,-0.023865065,-0.016944684,0.0068579777,0.041657608,0.026042754,-0.009578851,0.024086256,-0.009066772,0.03352794,0.08034312,0.082375236,-0.019587666,-0.047357365,0.043653272,0.0330813,-0.0055967616,-0.038467687,0.024629932,0.103297725,0.02776484,0.06936087,0.06860902,-0.020589672,-0.047223784,0.01696173,-0.046294257,-0.052575354,-0.018189052,0.1070765,-0.009162354,0.008368277,0.09183303,0.0037259557,0.013304053,0.047218416,-0.016717609,-0.005519984,0.048453078,0.05629473,0.019387994,-0.088992804,-0.09176128,-0.056647055,0.026772628,-0.040890582,0.05567712,-0.040088218,0.020893732,0.02525741,-0.016575225,0.08667502,-0.013070974,-0.085450515,0.018887602,-0.054629557,0.04384231,-0.017988633,-0.049144085,0.042086363,0.007480621,1.2329112e-05,0.09094716,-0.041097756,-0.0513655,0.04448327,0.022793215,0.012915124,0.017858567,-0.050159033,-0.11029251,-0.049113702,-0.025621116,-0.0021657585,-0.08216557,0.008511962,-0.014460285,-0.0617295,0.060019054,-0.054255936,0.010582199,0.089585096,0.0054128473,0.012301687,-0.07877668,0.018924078,0.049391035,0.027879138,0.06575203,-3.282403e-08,0.049911324,-0.03981146,-0.024230953,-0.014916475,-0.054997925,-0.003951266,-0.025556358,0.029167252,-0.0026594081,-0.006253695,-0.026436968,0.0324781,-0.0519569,0.026266657,0.008567608,0.056876086,-0.094980605,-0.12921001,-0.007454611,-0.043553613,-0.03746137,0.016790615,-0.04830969,0.093884766,-0.056431342,-0.06542141,-0.03143603,-0.031314626,0.005771813,-0.04093803,0.07531664,0.0118616745,-0.004726541,-0.04169185,-0.022610748,0.036028493,-0.032247838,0.021419438,0.035094198,0.028738247,0.026360275,-0.047082443,-0.10951867,0.04099581,0.05809408,0.045767896,-0.09523871,0.118663974,-0.038562432,-0.00072391116,0.010986743,0.025078503,0.01562406,-0.012176869,-0.05799829,0.007660141,0.009007325,-0.038992275,0.02858722,0.041062523,-0.019401845,0.0152707165,0.06361772,-0.11342824 +2.7.8.47,Involved in the biosynthesis of teichoic acid linkage units in the cell wall of Bacillus subtilis W23. This enzyme adds the 25-35 ribitol units to the linker molecule.,384,1.0,-0.007117703,-0.058539532,-0.078827076,-0.047271475,-0.005850414,0.043563195,-0.12467072,0.07363308,0.058537997,-0.059662264,0.073487185,-0.10664992,0.0737882,0.027086973,-0.07187518,0.00064105215,-0.06959152,0.014065372,-0.05921731,-0.068801634,0.025601108,0.090862565,-0.009688444,-0.0150128165,0.011648086,-0.057497438,0.029283432,-0.061378315,-0.008852789,-0.014968041,-0.02334446,-0.029369043,0.031826165,-0.08322948,0.028413901,0.019952307,-0.019744044,-0.007915575,0.16309176,0.048012346,0.009087716,-0.00019390379,-0.005676749,-0.006246185,0.0011088382,0.041017994,0.0017277058,0.05240853,-0.0060489443,0.034007434,-0.07016498,0.07023743,-0.049694188,0.03803562,0.04031079,0.025479129,0.0123053985,-0.0021364123,0.03426708,-0.0022466874,0.019073807,-0.061415464,0.043063153,-0.061932813,0.0026274198,-0.068750724,0.013568694,0.017457616,-0.010292153,-0.03222843,-0.024924237,0.018513,0.02129685,0.04473765,0.018243762,0.06360336,-0.033393,-0.005572496,-0.01207175,-0.046705816,-0.005417166,-0.025728853,-0.025867054,0.10707036,0.03557388,-0.030179093,0.024630882,-0.018341392,0.040314313,0.07259894,0.02666292,-0.018560037,0.008007628,-0.06537655,-0.0028476468,-0.021817714,-0.03530894,-0.03201021,-0.0044544335,-0.09213134,-0.053016502,0.04186494,0.02406534,-0.010096592,-0.07627632,-0.03355639,0.02189785,0.15844516,0.02653491,0.042313263,0.090868555,-0.02204811,0.012223931,-0.09651766,0.024132477,0.03340751,0.028936092,-0.09196413,-0.001539857,-0.06698114,0.058429655,0.026543599,0.022307958,0.01715126,-0.06439097,-0.03204079,-0.026574142,2.2225568e-33,0.11223776,0.017748304,-0.027215054,0.035928257,0.018354865,0.0036402536,-0.12375416,-0.029331248,-0.018044574,-0.020485409,-0.16538796,-0.099372804,0.018411806,0.004833666,0.013156485,0.028014563,0.0043285107,-0.012965496,-0.026650868,-0.008342326,-0.012436866,0.10212463,-0.006300771,0.008152938,0.036325607,0.029937038,0.032428976,-0.06270916,-0.020461513,-0.028003693,0.033462048,0.00443118,-0.086568005,-0.0019301618,0.08754717,0.02048892,-0.051709354,0.018212574,-0.0052752355,0.00078417454,0.03274485,0.07507487,0.04497217,-0.040457767,0.09965133,0.02911665,0.040335048,0.042693432,-0.028204843,0.05417886,0.037566733,0.071397856,0.087626286,-0.0055935853,-0.013998001,-0.0059208563,-0.020261124,0.043037698,-0.019469857,0.08450886,-0.019994201,0.0053129657,0.0038761217,0.118400775,-0.053982988,0.020768663,-0.06765293,-0.030586949,0.01755661,0.007160991,-0.04674912,-0.010006996,0.09405885,-0.005455633,-0.07956522,-0.008197358,-0.048925385,-0.06674921,-0.02144053,-0.04710339,-0.029997738,-0.008706829,-0.019728398,-0.03488911,-0.024672132,0.018504968,-0.010266597,-0.06842724,-0.014533647,0.03893283,0.09812842,-0.092953764,-0.06030214,0.10417785,0.0050302735,-3.0759741e-33,0.1378337,-0.08531465,0.094104014,-0.11276607,-0.09205782,-0.0036234714,-0.025862798,-0.015557793,-0.01618758,0.0040361276,0.061975632,0.040083442,-0.0086582,0.019057447,-0.01651562,0.031943094,0.07173015,0.08694988,-0.0061216406,-0.041790426,0.04948891,0.032935143,0.0030214898,-0.02778303,0.023856431,0.0985396,0.03865218,0.042404223,0.06954744,-0.028068282,-0.03904126,-0.00162349,-0.03492411,-0.036744624,-0.007279067,0.10230485,0.011790424,0.008097923,0.086054064,-0.010022495,0.011137882,0.028831959,-0.021091416,0.0028023191,0.042423524,0.053642016,0.008922386,-0.09817894,-0.09051115,-0.07060215,0.023698308,-0.03829331,0.056362256,-0.05677053,0.020020159,0.010224165,-0.03071696,0.08921763,-0.016192602,-0.06799947,0.027792841,-0.06465274,0.06058416,-0.019773573,-0.059204843,0.052345593,0.005557731,-0.011710479,0.07483599,-0.037714813,-0.059170786,0.03857277,0.03361096,0.029747192,0.015686486,-0.059944917,-0.07960738,-0.062527664,-0.016061967,0.005473079,-0.07924158,-0.0016889609,-0.011914809,-0.068564,0.06103114,-0.054028194,0.027274325,0.10407313,0.02202694,0.012353234,-0.06250819,0.011278592,0.047792576,0.02425553,0.0587742,-3.0375308e-08,0.063648514,-0.031030037,-0.03173245,-0.030765012,-0.050024148,0.02214806,-0.033315446,0.0355458,0.003734733,0.003466154,-0.0068065,0.021543423,-0.06673651,0.034462176,0.026795577,0.020857861,-0.09895993,-0.12035297,-0.008638585,-0.049731694,-0.046179328,0.030253876,-0.0486886,0.09123362,-0.05616537,-0.061042085,-0.031143868,-0.011763341,0.0022733808,-0.05493384,0.0759465,0.008314218,-0.01917229,-0.02350274,-0.0429779,0.037149522,-0.037375882,0.027157472,0.033814944,0.0635075,0.029922651,-0.076362774,-0.11566708,0.034163922,0.06350907,0.036830906,-0.110401385,0.10942416,-0.047813613,-0.016713329,0.02995241,0.04492724,0.019799093,-0.015985088,-0.059988108,0.016797727,-0.004592841,-0.037011553,0.010673783,0.03370615,-0.026446888,0.0020223511,0.044035744,-0.110054135 +3.1.11.7,"Aprataxin is a DNA-binding protein involved in different types of DNA break repair. The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus. It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, ribonuclease H, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction. Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined. The enzyme also possesses the activities of EC 3.1.11.8, guanosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.1.12.2, DNA-3'-diphospho-5'-guanosine diphosphatase.",384,1.0,-0.06605446,-0.09450619,-0.024411367,-0.05622612,0.05290293,-0.0051842346,-0.0061624125,0.025902659,-0.0016044052,-0.005406657,0.0833735,-0.0013056882,-0.09403607,0.039906565,-0.060817145,0.08589297,-0.07531856,-0.01444377,-0.029457264,0.020052286,0.009987697,0.08018272,-0.005196595,-0.016152738,0.008297998,-0.0015641963,0.06868583,0.024148403,-0.023036784,-0.1497019,-0.03736515,-0.07891994,-0.0216403,0.00058134575,0.025009416,0.12891833,-0.008691144,-0.025781399,0.0033435863,0.019051412,0.03681758,0.040485,-0.014840296,0.038762942,0.050299518,0.0020713103,-0.032215387,0.047661,0.04726895,0.0029704715,-0.012211731,-0.064876966,0.01882856,0.07155207,0.057729796,0.018446308,-0.07006329,-0.020086057,-0.013662453,0.04496941,0.055362076,0.009303899,-0.030657398,-0.066004336,0.088084266,-0.073178664,0.08337618,-0.07005753,-0.009884158,-0.028565262,-0.011272081,-0.08527687,-0.019143548,0.053155433,0.042650413,0.039799895,-0.04323909,-0.048435386,0.03719977,0.027053576,-0.08674715,0.039525084,0.05161518,0.058064595,0.061000686,0.0042238664,0.0010523896,0.0141608715,0.022301061,0.02397475,0.0035495763,-0.017590003,0.05157339,-0.051082008,-0.008513323,0.05679135,-0.03375647,0.0019211927,0.01246181,-0.03624124,0.032722153,0.058161877,-0.13694838,-0.06161475,-0.036838897,-0.029976968,-0.026148643,0.06860364,0.020527372,0.017983168,-0.04901168,-0.003982409,-0.0228656,-0.025957266,-0.059831336,0.05637399,-0.016321177,-0.043138333,0.05124995,0.032684717,-0.021168832,0.013868962,-0.004229687,0.08151018,0.033951994,-0.013865284,-0.069314644,1.558046e-33,-0.0046990532,-0.00553663,-0.03485613,0.03774442,0.053322002,0.0013421287,-0.10779641,-0.04632115,-0.080638,-0.008475433,-0.03196531,-0.021027235,0.023564633,-0.048226383,-0.012736675,-0.0407784,-0.06070428,-0.0010339798,-0.02699838,0.015742142,-0.009136783,0.0318423,0.01724626,0.031196121,0.021599937,0.026853958,-0.029682633,0.063846655,0.09613527,-0.010187294,-0.035628565,-0.0287167,-0.0614522,0.05069678,-0.021822564,-0.042712495,0.031773023,-0.056633282,-0.031754896,0.112374075,-0.060630977,0.03563264,-0.040887844,-0.047179658,0.098962724,-0.14079052,-0.027668284,0.065170646,0.020063093,-0.039677236,0.07164108,-0.093298,0.12045787,-0.018480252,-0.07695179,0.039649658,-0.081404194,-0.03062876,0.04720318,0.0438964,0.012757872,0.0008555003,-0.01121252,0.032291636,-0.021336718,0.038728185,-0.036564015,-0.033172425,0.07154992,0.09821232,-0.030317727,-0.022391956,0.047964916,0.01573885,-0.041556045,-0.019346451,-0.11799994,-0.016386786,-0.02541849,0.07074041,0.004699519,-0.054582022,0.060802255,0.018572213,-0.06396985,-0.03164764,-0.0031696125,-0.058232747,0.039590385,-0.008319473,0.101912916,-0.019367993,-0.04067319,-0.0603923,0.06541462,-1.9579758e-33,0.15872866,-0.11136958,0.059990153,-0.051301435,-0.014210239,-0.0073280246,-0.013498177,0.021542076,0.034044784,-0.07215174,0.05553704,-0.020122655,-0.02726105,-0.007778829,-0.02717109,0.037463695,-0.04530409,0.083626874,0.0014853699,0.0010094123,-0.02512621,0.034336157,-0.00026492344,0.07091237,0.015108179,0.01150102,-0.030670665,0.038087703,0.04769342,0.01164042,-0.05217405,-0.028412957,-0.027518194,0.044288702,0.0024858334,0.04457373,-0.0066261063,0.019234471,0.012475754,-0.003930422,0.057896335,0.046906035,-0.0341737,0.055873595,-0.013324268,0.089082316,-0.014964662,0.06997628,-0.041477844,-0.09327683,0.07734254,-0.02623087,0.06459488,0.05212677,0.0069610775,0.013377503,0.029199168,-0.02401333,0.018153645,0.036345627,-0.017325433,-0.088587224,0.023681952,0.02424364,0.1005366,0.00041072222,-0.029278142,0.072351456,0.032360997,0.033434078,0.0314173,0.066498145,0.04464598,-0.01022521,-0.010571278,0.006462182,-0.057843518,-0.028174937,0.059193563,-0.013820622,-0.0037515627,-0.0047452627,-0.07640957,-0.0036772746,0.059845418,-0.008925479,0.036069553,0.19536339,-0.0049805176,-0.016866192,-0.020332322,-0.012263057,0.013664799,0.019826405,0.008962561,-5.212891e-08,0.11551065,-0.042758346,-0.0401468,-0.0820243,0.040927522,0.01841935,0.0051219966,0.09344033,0.07500271,0.029540896,0.0023936264,0.11942058,-0.018293971,-0.011223394,0.037475184,-0.008664973,0.019250846,0.050923005,-0.001386431,-0.016778832,-0.095074534,0.036964964,-0.113467135,0.0050689476,-0.062068507,0.0074193752,0.047537547,0.09147534,-0.044005558,-0.033299074,-0.028451733,-0.029177029,0.038080204,-0.05808693,-0.11589948,0.059981752,0.03348381,-0.03178094,-0.024779897,0.023685591,0.034814414,-0.0046590194,-0.06492878,-0.030368783,-0.027750384,-0.015180704,0.0065259654,0.002121559,-0.03701651,-0.012950202,0.08089114,0.00713595,0.008973311,-0.07287764,-0.13492873,-0.03265604,-0.021039559,-0.06626872,-0.023373742,-0.035561834,0.00073080405,0.006942001,0.17050873,-0.03430501 +3.1.11.8,"Aprataxin is a DNA-binding protein that catalyses (among other activities) the 5' decapping of Gpp-DNA (formed by homologs of RtcB3 from the bacterium Myxococcus xanthus). The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and eventual release. The enzyme forms a 5'-phospho terminus that can be efficiently joined by ""classical"" ligases. The enzyme also possesses the activitiy of EC 3.1.11.7, adenosine-5'-diphospho-5'-[DNA] diphosphatase and EC 3.1.12.2, DNA-3'-diphospho-5'-guanosine diphosphatase. ",384,0.99999994,-0.06857065,-0.098366484,-0.089451365,-0.04614767,0.03656412,-0.032519095,0.032165345,0.031537034,-0.008471754,-0.023818683,0.100355424,-0.05299569,-0.030175453,0.06365023,-0.082118794,0.04946932,-0.038697317,-0.03198289,0.02713157,0.0028987557,0.007002599,0.05093616,-0.007399272,-0.035282977,0.043589592,0.0016052984,0.112000436,0.0071511553,0.0068167597,-0.10909832,-0.06523648,-0.06886103,0.011732986,-0.029050758,0.039929982,0.14254715,-0.023587024,-0.03605559,0.031220557,0.00066091155,0.060002383,0.022746034,0.0055303853,0.06417989,0.02603751,0.014108757,-0.035288975,0.07310704,0.0112210605,-0.009918635,-0.061490975,-0.056463577,0.009554872,0.06863653,0.0082082255,-0.015245059,-0.1022476,-0.069635026,-0.017005557,0.030517124,0.038763463,-0.017061342,-0.003803979,-0.061448358,0.007436844,-0.04821731,0.062272567,-0.034942,0.009138674,-0.004822436,-0.010541049,-0.024191082,-0.033971403,0.04753687,0.0062516606,0.036061175,-0.04551858,-0.04892261,0.042207886,0.05135686,-0.05636218,0.052685853,0.050673865,0.05940933,0.058684286,-0.007286812,0.032483403,0.020963458,0.004245687,0.061884623,0.029943645,-0.021357404,0.04794489,-0.07512908,-0.024014207,-0.001422688,-0.019504625,0.0013217279,0.029893348,-0.055975597,0.024620406,0.01887784,-0.13461041,-0.018955443,-0.045121778,0.003016576,-0.045711827,0.08147023,-0.003875547,0.029736744,-0.09362391,0.01755954,-0.028906237,-0.0658242,-0.07024113,0.059239555,0.017163103,-0.055102233,-0.0424456,0.051874347,-0.027776053,0.0042034187,-0.059616882,0.07988099,-0.018023644,-0.055348385,-0.09660531,3.3511243e-33,-0.021755649,0.014864761,-0.046471126,-0.00979321,0.0781243,0.0012042794,-0.098916724,-0.04094742,-0.0948828,0.0009296644,-0.046626367,-0.00914893,0.014031671,-0.0035642069,-0.031688403,-0.012342861,-0.03742818,0.019531632,0.057422403,0.025133703,0.021238055,0.021518916,0.0022023802,-0.017151231,0.014800303,0.074722424,-0.045123752,0.005286272,0.08601546,-0.019974016,-0.008344431,-0.07697185,-0.10034361,0.028430117,0.0053975047,-0.028260676,0.044283066,-0.07801151,-0.026790425,0.10250143,-0.037609357,0.050520528,-0.018030522,-0.049497016,0.079667315,-0.09473531,-0.055751245,0.06531314,0.029921278,-0.010991077,0.08774797,-0.08375956,0.10982101,0.00101907,-0.07632661,0.0023156232,-0.1005367,0.008005267,0.015166806,0.04649898,0.022367489,0.009645355,-0.020457199,0.034241952,-0.061733015,0.054045603,-0.064584374,-0.024268476,0.06558408,0.12956743,-0.042150643,-0.04038381,0.027526714,0.008213797,0.013700459,-0.026708318,-0.116099566,-0.036123715,-0.012302162,0.043582253,-0.006223598,-0.023352297,0.060476787,0.043844208,-0.05620669,-0.03610916,-0.012262823,-0.014776804,0.004355365,0.010720328,0.09157232,-0.014437714,-0.025700405,0.016111173,0.023755549,-3.8135064e-33,0.17492352,-0.09752883,0.051220525,-0.07810921,-0.029270053,0.0042610164,0.020201173,0.004067422,0.040250003,-0.044882122,0.06817816,-0.013136169,-0.030160012,0.020751163,-0.015209365,0.032335375,-0.0012114992,0.101742476,-0.015770385,-0.06579291,-0.066077225,0.032464467,0.026953865,0.008146334,-0.0017089839,0.010363133,-0.023110308,0.072650544,0.031013768,0.040655676,-0.09611393,-0.010073596,-0.052465856,-0.029797617,-0.005714812,0.032522257,-0.035782788,0.04746939,0.057873458,0.020113394,0.0449601,0.063204244,0.018452365,0.07114691,-0.038949635,0.13523294,6.6474655e-05,0.045750376,-0.039802458,-0.08209263,0.04115851,0.0043903547,0.02357814,0.029455937,-0.0029875753,0.042618457,0.023947785,-0.02753124,0.03874632,0.034763955,0.016667461,-0.102429464,0.0041114115,-0.0018544374,0.08977664,0.038881276,0.0022070967,0.065473914,0.03711284,0.021260997,0.017820898,0.02902797,0.021347443,0.027505897,-0.008021638,-0.00017579034,-0.024810303,0.0011445496,0.10751492,-0.006330974,0.024887396,0.0034775308,-0.068615004,-0.028389983,0.03395688,-0.020362679,0.06988796,0.15692405,0.020400967,0.039596822,-0.0010101567,0.01822466,0.0070538484,0.016350664,0.042026635,-5.1437915e-08,0.10562926,-0.07620462,-0.014068736,-0.077309676,0.033779543,0.05942262,-0.03563049,0.03379283,0.0982324,0.008033771,0.049608316,0.048992928,-0.008617359,-0.03604463,0.054298125,-0.016475502,-0.00041228408,0.022771519,0.0033852085,-0.030356392,-0.08572588,0.041848633,-0.1242015,-0.0031870343,-0.048289474,-0.033416808,0.056354705,0.06861988,-0.049139246,0.022523414,-0.04178813,0.020529097,-0.018595185,-0.056957062,-0.09809566,0.06207998,-0.038272966,-0.048049882,-0.0076951357,-0.0073940465,0.05112034,-0.0015411217,-0.08219941,-0.008493059,-0.009084081,0.030740153,0.013740449,-0.03394456,0.012963251,0.022458533,0.090168215,-0.009708402,0.03273062,-0.05426332,-0.10320236,-0.011244575,-0.049025398,-0.07880108,-0.06887249,-0.059838425,-0.0061943373,0.027994404,0.14815477,-0.053218223 +3.1.12.2,"Aprataxin is a DNA-binding protein that catalyses (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8, 3'-phosphate/5'-hydroxy nucleic acid ligase) [1]. The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release. The enzyme also possesses the activity of EC 3.1.11.7, adenosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.1.11.8, guanosine-5'-diphospho-5'-[DNA] diphosphatase.",384,1.0,-0.08275221,-0.07395542,-0.0665077,-0.037141107,0.03920154,0.001414542,0.02178287,0.033565376,0.01334103,-0.04600334,0.11064803,-0.026301218,-0.06281545,0.031457033,-0.06417923,0.05972522,-0.04212259,-0.04152121,0.028901432,-0.029358087,0.0037809997,0.029240854,-0.007778581,-0.012025364,0.04792808,0.018549934,0.10728781,0.034180954,0.024818376,-0.1190087,-0.049871527,-0.057759587,0.011214523,0.011018358,0.022874545,0.13435638,-0.033873428,-0.017567826,0.011133664,0.013385645,0.061893858,0.03698497,-0.0057026637,0.04957644,0.027143607,-0.0035121741,-0.024934692,0.035579078,-0.0024630625,-0.00865208,-0.022843102,-0.09328645,0.008040699,0.04217015,0.0019011429,-0.03802643,-0.09400006,-0.03043329,-0.01730648,0.01760442,0.02516938,-0.0191021,-0.026744744,-0.061877087,0.042432588,-0.05012378,0.09350189,-0.024678372,0.002418484,-0.031768586,0.014203566,-0.039863724,0.011875228,0.043542847,-0.027982682,0.03093164,-0.068331644,-0.051502164,0.06316833,0.045868363,-0.03082067,0.052587215,0.02407807,0.065013826,0.06524204,0.003091966,-0.0068959184,0.04765329,-0.0035749734,0.02973777,0.03325551,-0.02084844,0.032596745,-0.04266793,-0.030946337,0.06398304,-0.051068116,-0.009600051,0.018938333,-0.046296332,0.05778655,0.074012324,-0.14127581,-0.026650645,-0.034333773,0.012444933,0.018566087,0.05878156,0.0014927962,0.03706978,-0.09282781,0.014390092,-0.018693505,-0.039397966,-0.09128283,0.06694457,0.015022278,-0.016103612,-0.023554765,0.039917607,-0.015138416,0.03846722,-0.034500983,0.07794602,0.025783682,-0.024527818,-0.08541671,1.4912133e-33,0.022617986,-0.009033462,-0.032651935,0.021375036,0.059242025,0.03754989,-0.09588181,-0.040467262,-0.0920566,0.026654683,-0.051485058,-0.022682684,0.021446584,0.021572273,-0.012677798,-0.017739909,-0.02571699,0.011158863,0.06064887,-0.026391312,0.018127378,0.005695309,-0.01698238,0.009846213,0.005509058,0.071096405,-0.072102286,0.03669535,0.073460445,-0.019929713,-0.019248985,-0.04811382,-0.092528105,0.04402562,-0.0036313573,-0.024452036,0.032493297,-0.05790491,-0.024536366,0.10956055,-0.03653174,0.023789853,-0.03520258,-0.058650274,0.06608263,-0.11425022,-0.06327569,0.0657498,0.051226236,-0.026846197,0.06429754,-0.07924631,0.109670095,-0.018792355,-0.058320627,0.023232,-0.08154344,-0.008166012,0.035878096,0.050677612,0.044754107,0.02793286,-0.021094192,-0.010292745,-0.013376824,0.06913564,-0.0860227,-0.020976359,0.058562912,0.12824978,-0.005781883,-0.04503012,0.0037201855,0.028554594,0.00056029676,-0.028158657,-0.12219417,-0.01730558,-0.027130006,0.052627817,-0.012062857,-0.058174815,0.047254577,0.022093916,-0.083984815,0.008428125,-0.007509711,-0.029445898,0.032561295,0.041848324,0.073137596,0.0054707085,-0.038878538,-0.028618047,0.024037022,-1.3661366e-33,0.14130323,-0.06273351,0.002291218,-0.0869028,-0.024483172,-0.0063375076,0.021440053,0.0050721937,0.04353332,-0.034071974,0.03951844,-0.03813744,-0.024865612,-0.008645212,-0.015849648,0.0822533,-0.048975736,0.08796722,0.008993352,-0.040433444,-0.08565443,0.02149995,0.041458298,0.05725221,0.019280594,0.012850358,-0.0023253702,0.019241389,0.03980527,0.03299656,-0.10536478,-0.010381722,-0.035834644,-0.02018232,-0.029335672,0.029810516,-0.020372797,0.049210027,0.028646817,0.0016065828,0.029940626,0.06791721,0.018614816,0.08224597,-0.0044170157,0.12738265,0.028327575,0.043897294,-0.052482817,-0.09804892,0.029783895,0.00205705,0.03846292,0.056931965,0.015850963,0.026405009,-0.008369771,-0.06809671,0.06670111,0.00067466585,0.02430192,-0.1054735,-0.05432785,-0.010016658,0.06991139,0.045463264,-0.028432248,0.06851452,0.037039958,0.039743803,0.03804985,0.00504965,0.048331838,-0.005272048,-0.022235332,0.0074278,-0.036347657,0.028980441,0.09154259,-0.029771773,0.041936237,0.014649283,-0.0974026,-0.024966853,0.012480879,0.0027946872,0.048946314,0.15859155,0.030657755,0.04156029,-0.03720894,-0.017293502,-0.0114664035,0.05289176,0.042769864,-4.8882317e-08,0.11602339,-0.098783925,-0.011505137,-0.07457165,0.02139241,0.057118494,0.021339789,0.07324908,0.08676597,0.015039026,0.0059857117,0.08818721,-0.008324959,-0.009855767,0.03809,0.016679035,0.021064034,0.05968883,-0.0023065065,-0.03659163,-0.05484102,0.03559916,-0.13851799,0.024208728,-0.05616379,-0.0075589167,0.03970284,0.0753464,-0.04581792,-0.0030744518,-0.034159813,0.01948132,0.016507154,-0.09595421,-0.06374372,0.07539362,0.013971785,-0.04907195,-0.0015420051,-0.011934738,0.007615393,-0.0077106766,-0.085455574,-0.024665486,-0.044191286,-0.020677654,0.028279258,-0.010208824,0.014257625,0.012886663,0.097886,-0.03738215,0.030263564,-0.041426964,-0.11185914,-0.048478104,-0.03908853,-0.09187848,-0.0701045,-0.08932564,-0.0002633918,-0.0003271658,0.16707554,-0.053225003 +3.2.1.200,"The enzyme hydrolyses the second glycosidic (1->4) linkage from non-reducing ends of chitin and chitodextrin molecules, liberating N,N'-diacetylchitobiose disaccharides. cf. EC 3.2.1.201, exo-chitinase (reducing end).",384,0.99999994,-0.01748457,-0.12704284,-0.02780368,0.03899985,0.010718166,0.0255958,-0.019582372,-0.009207691,0.0039017769,0.051148668,0.10279635,0.034687635,-0.046638146,0.06737738,-0.11412322,0.008073735,-0.0090186,0.0066337045,-0.086871035,0.029230192,0.0933069,-0.04479789,0.052235067,0.01389115,0.048602335,-0.010590879,0.013987407,-0.03128533,0.0013670498,-0.09477111,0.0124658,-0.036848698,-0.05752686,-0.018679025,-0.015879475,0.041838594,0.053014304,0.04351979,0.061081152,-0.035677634,-0.012904331,-0.046972226,-0.034246437,-0.00082090416,0.0013823305,-0.053506278,-0.057057805,0.06298786,0.049432643,-0.001061042,-0.0020473194,0.033050567,-0.049587686,-0.011206405,0.023563283,0.09404751,-0.0507091,-0.08408591,0.050539494,0.13070361,0.046509124,0.042822417,-0.051625475,0.007216674,-0.04013756,-0.0698164,0.04730457,-0.034488127,-0.018648747,0.021886226,-0.033191863,-0.049617846,-0.056837294,-0.046919804,0.048505407,0.055418212,-0.06681321,-0.015674377,0.008202797,-0.05290266,0.024937367,-0.018890658,0.07307323,0.12452339,-0.02514673,-0.03821217,0.015471159,-0.03836488,0.029830765,0.031450108,0.009115939,-0.033157848,0.049352866,-0.012136293,-0.05325284,-0.043221023,0.00029546858,-0.005063079,0.06893323,0.0022001893,0.008610142,-0.04004061,0.02795691,-0.08155076,0.004602956,0.055742383,0.05759117,0.06005164,0.08198395,-0.011709933,-0.007700036,0.09337036,-0.022549815,-0.022592537,-0.07454463,0.09367151,0.018430645,-0.046801012,0.06703994,0.015622656,-0.0038466912,0.020579929,0.0023222298,0.08886103,-0.026906295,0.011812302,0.002833657,2.7815736e-33,0.035197377,-0.0590713,0.06628623,-0.037868917,0.010551191,0.014528501,-0.10481689,-0.036428947,-0.0135075385,-0.010241858,-0.05866172,-0.022483634,-0.056975,0.08775412,-0.008242302,0.03702966,0.0078101433,-0.018608963,0.030895839,-0.0022332394,-0.039487556,0.09394705,-0.025720583,-0.03428711,0.13300806,0.06541855,-0.04909177,0.035319358,0.09977042,-0.0028034863,0.08406796,-0.010382591,-0.041046172,0.0228222,0.022048762,0.08454535,0.018013233,-0.010548907,0.048447996,0.03459588,0.018230617,0.051574484,-0.037391126,-0.0612296,0.029687552,-0.05520541,0.040319227,-0.0010238598,-0.047747396,0.052798245,0.050955232,-0.05480926,0.06621256,0.059350703,-0.0039430405,0.005922369,-0.008183101,0.03392398,0.059427403,0.05198563,-0.014264692,0.015805516,-0.019959358,-0.043216523,0.06379445,-0.0013530722,-0.010295528,-0.008902787,-0.038053844,-0.042829745,-0.109619275,-0.021580972,0.06859888,-0.0073964773,0.02830076,-0.070527054,-0.06772795,-0.0047128787,0.006534429,-0.025071962,0.054060772,0.024266342,-0.0076823966,-0.022223042,-0.061079558,0.05974608,-0.0622827,-0.096392974,-0.022015147,0.015948923,-0.0032426692,-0.028199129,-0.034815747,0.045251492,-0.008671855,-3.647327e-33,0.11375848,-0.07225848,0.10570938,0.0009583342,-0.05638321,0.046301074,-0.012873024,-0.001483742,-0.022811174,-0.02011837,0.031087663,-0.005733072,0.0904809,-0.021993378,-0.05052748,-0.00034490734,-0.013850319,0.06991628,-0.017565286,-0.00017154434,-0.099925645,0.054020114,0.04015244,-0.04766369,0.089477815,0.0005364566,-0.0016593612,0.068653546,0.005896661,-0.021895733,-0.034017306,-0.035106707,-0.044323545,-0.101365104,-0.034456212,0.0159724,-0.09462157,0.043326754,-0.010049374,-0.040891945,-0.038939606,0.015271479,0.043929253,0.0010655603,0.030238338,0.048310176,-0.06011228,-0.09202118,-0.043507773,-0.017966188,0.024372326,-0.009747487,-0.04678097,0.08640312,0.039916795,0.054150224,0.07055758,0.044799503,0.008198634,-0.04825781,-0.045901213,0.031840246,0.092890404,-0.036501486,0.06667562,0.07064503,-0.04775877,0.09960945,0.03742332,-0.051693648,0.0069703106,0.011834897,0.041336562,0.01806508,0.050098523,0.05897274,-0.12384493,-0.07465416,-0.042631164,-0.029718587,0.013837494,-0.023652075,-0.07540034,-0.095956646,-0.0016811609,-0.048449907,0.04435138,0.13302052,-0.010880737,0.10295805,0.035225935,-0.023168711,-0.01186486,0.036342338,0.040868104,-3.4071075e-08,0.05052666,-0.06943641,0.0031021077,-0.09419412,-0.010217764,0.047479052,0.035309043,0.029185567,-0.042872917,-0.021919139,0.042366777,0.10912334,-0.039814375,0.021919947,-0.041687954,0.018600136,-0.0064405454,-0.016511975,0.0038969084,0.032734957,-0.10726384,0.069862306,-0.0949652,0.03364747,-0.021335943,-0.052048575,0.03025542,0.045156017,-0.05437545,-0.057683315,0.040360972,0.086160235,-0.05843148,-0.101097584,-0.056215893,0.014081134,-0.027704006,-0.005586612,-0.0020676823,0.017568445,0.020609707,0.014302016,-0.054888584,-0.012668483,0.019861149,-0.011930079,0.00024517206,0.060427014,-0.031016972,0.06639802,-0.0062247165,-0.01693611,-0.06537372,-0.13582002,-0.13078022,-0.002466596,0.01569495,-0.02489652,-0.04764765,-0.040214475,-0.08884836,-0.07354332,0.09821857,0.009582242 +3.2.1.201,"The enzyme hydrolyses the second glycosidic (1->4) linkage from reducing ends of chitin and chitodextrin molecules, liberating N,N'-diacetylchitobiose disaccharides. cf. EC 3.2.1.200, exo-chitinase (non-reducing end).",384,0.99999994,-0.02061142,-0.12364745,-0.02593362,0.037457164,0.01030495,0.0212297,-0.021622216,-0.005533667,0.0005845235,0.049688417,0.10069783,0.03035344,-0.050476216,0.06738913,-0.11179133,0.007756555,-0.004712153,0.008279551,-0.089812756,0.02482117,0.0907119,-0.04927852,0.05484847,0.017176818,0.047175292,-0.010634951,0.014193143,-0.02476329,0.0011791732,-0.09034998,0.019474125,-0.036421884,-0.050184704,-0.019547746,-0.023754908,0.042109977,0.052088402,0.042044047,0.060301345,-0.034401704,-0.018589223,-0.044559356,-0.035666376,-0.0051984224,0.00033103846,-0.052851897,-0.05936809,0.06706875,0.04967753,-0.0068630185,0.0017649138,0.033102192,-0.052286446,-0.014770196,0.028336402,0.092576414,-0.05479822,-0.08398053,0.048646808,0.13000791,0.047948997,0.04396405,-0.051383562,0.011155297,-0.03872526,-0.06802213,0.04689051,-0.038617454,-0.01704535,0.021364564,-0.034581326,-0.048379254,-0.05817982,-0.04704874,0.051537167,0.05514898,-0.06317417,-0.018944334,0.013948324,-0.05018741,0.025719913,-0.014181428,0.06806029,0.12541689,-0.02412776,-0.038920723,0.01707643,-0.04544287,0.027793432,0.029749505,0.009144738,-0.03270713,0.050304573,-0.017027212,-0.058707424,-0.04144109,-0.0032355671,-0.004909247,0.06835585,0.0060339714,0.009646601,-0.036508128,0.02953057,-0.08450081,0.0013321916,0.052795246,0.061043277,0.0616326,0.083634906,-0.007133217,-0.010546139,0.093942165,-0.02846625,-0.018838769,-0.076113805,0.09743105,0.018696856,-0.044773754,0.071488775,0.017514875,-0.0033794986,0.021155706,0.0026387838,0.08621594,-0.02236664,0.01083055,0.0010254371,2.9270976e-33,0.033515994,-0.059361786,0.06324979,-0.03634206,0.012819565,0.017504346,-0.102797024,-0.036988247,-0.009854356,-0.008770032,-0.05364219,-0.023411714,-0.054629657,0.09487784,-0.008284373,0.029497279,0.0015749949,-0.017361978,0.03278549,-0.0006974276,-0.035370816,0.091693,-0.018457074,-0.032884516,0.13688424,0.06089192,-0.04614505,0.0376851,0.10099205,-0.0024209025,0.08744515,-0.009801432,-0.045425817,0.018983167,0.020564562,0.08433153,0.01812659,-0.012320228,0.05254055,0.036916986,0.0139224185,0.055882826,-0.038139507,-0.061630264,0.02905786,-0.04974634,0.038922194,0.00039774855,-0.04370718,0.049292922,0.053767413,-0.055991225,0.06697514,0.057821542,0.0019769107,0.006302997,-0.0064834133,0.031638287,0.059568487,0.047698542,-0.013558074,0.018424802,-0.018942153,-0.040477525,0.06788827,-0.004573218,-0.008964279,-0.011319828,-0.038585067,-0.04433192,-0.10801358,-0.018937724,0.0694182,-0.009212241,0.02669066,-0.07315756,-0.062010735,-0.0062838863,0.00014853968,-0.026164405,0.049141422,0.028385684,-0.006035178,-0.017789884,-0.05999831,0.059329506,-0.06064683,-0.09057514,-0.020565432,0.012059795,-0.0061977166,-0.02857216,-0.03387651,0.045268416,-0.010098934,-3.7523425e-33,0.1143451,-0.07183694,0.10533869,0.0056396658,-0.053078845,0.042303216,-0.011498058,-0.004755722,-0.022105306,-0.024731603,0.030494511,-0.004967135,0.09495118,-0.0237216,-0.04824648,0.0032965108,-0.019127764,0.0634919,-0.021851238,0.0032701266,-0.09918354,0.05552048,0.039417908,-0.04893774,0.08747303,-0.0027096025,-0.0043504112,0.071695246,0.00583902,-0.024016842,-0.040951043,-0.035289697,-0.045684807,-0.10214927,-0.03707233,0.01807628,-0.091945216,0.044031363,-0.011356349,-0.04031771,-0.03868325,0.017599227,0.042781442,-0.0020395014,0.027457867,0.052829813,-0.058129586,-0.09152158,-0.044530645,-0.014367573,0.021440055,-0.011069953,-0.046719063,0.085417554,0.041907206,0.052516654,0.072931685,0.04045251,0.0040063886,-0.04623339,-0.04747136,0.030164491,0.09841857,-0.0324208,0.062340323,0.07314489,-0.048724815,0.10086701,0.036678016,-0.054327585,0.010032184,0.011126457,0.04356184,0.015922824,0.050744884,0.055755258,-0.12582654,-0.07107151,-0.043433733,-0.025231503,0.01444577,-0.02648067,-0.079435855,-0.097824745,-0.0023827492,-0.045030598,0.04760113,0.13522664,-0.013589829,0.10087297,0.033583913,-0.024907475,-0.008483072,0.032746997,0.044636995,-3.4754137e-08,0.051498152,-0.07160206,0.0028140852,-0.09347667,-0.012138785,0.045985516,0.0313201,0.028358517,-0.0453015,-0.026016634,0.046989623,0.11285231,-0.04314786,0.026292784,-0.03952685,0.014171457,-0.011324923,-0.012792899,0.0025689865,0.027145194,-0.1061551,0.06977015,-0.096268214,0.028246352,-0.018810641,-0.051949296,0.03242988,0.04383352,-0.05894887,-0.058227394,0.038276542,0.087892205,-0.05574188,-0.09938443,-0.057763945,0.014059531,-0.028860033,-0.0029709218,-0.0036090033,0.018490896,0.019891249,0.017959587,-0.05638354,-0.014789918,0.013705497,-0.012436287,0.0022147642,0.06133827,-0.030211248,0.071204655,-0.009278881,-0.01259825,-0.06491008,-0.13458437,-0.12931228,0.0009515816,0.011408306,-0.028513549,-0.05098186,-0.037409972,-0.08556967,-0.0753647,0.1009838,0.009216287 +3.2.1.202,"The enzyme, characterized from the bacterium Vibrio furnissii, is an endo-cleaving chitodextrinase that participates in the the chitin catabolic pathway found in members of the Vibrionaceae. Unlike EC 3.2.1.14, chitinase, it has no activity on chitin. The smallest substrate is a tetrasaccharide, and the final products are N,N'-diacetylchitobiose and small amounts of N,N',N''-triacetylchitotriose. cf. EC 3.2.1.200, exo-chitinase (non-reducing end), and EC 3.2.1.201, exo-chitinase (reducing end).",384,0.99999994,-0.01795134,-0.08214222,-0.04769773,-0.021333767,0.04885936,0.034706026,-0.024002744,0.052003115,0.029316587,0.07531739,0.10973055,-0.10497414,-0.053491388,0.055820007,-0.08641146,-0.020304384,-0.010848872,-0.04879094,0.0016787559,-0.0026823136,0.10237529,0.009582262,0.052617427,-0.00085130293,0.003333109,0.006336469,-0.015698614,-0.029313743,-0.010613272,-0.04669683,-0.0044058906,-0.0490234,0.007160627,-0.013824444,-0.0040614465,0.061940826,0.015457607,-0.055918027,0.0561797,0.012691716,-0.01131312,-0.028323961,-0.034912594,-0.008526314,0.023776336,-0.022652572,0.00043211292,0.00545359,0.020407856,-0.08110291,-0.027522357,-0.026688468,-0.053014483,0.009116117,0.023255238,0.03856019,-0.02973135,-0.102709465,-0.013139179,0.11001912,0.08006881,0.019453822,0.02940107,-0.02853692,-0.025803847,-0.03002452,0.029233757,-0.059539538,0.015969737,-0.004636462,-0.060318984,-0.042317964,-0.097469114,0.06392356,0.027462702,0.098425694,-0.00122238,-0.019516418,-0.017344493,-0.0647601,-0.027484756,-0.019278582,0.004141678,0.11822945,0.003673341,-0.06698409,0.032430258,-0.02874552,0.04247917,0.09224743,0.016403321,-0.0034257474,0.0037173338,-0.033516876,-0.06767804,-0.014270126,-0.015978236,-0.0046207607,0.06969772,-0.024827382,-0.02124279,0.0045346078,-0.006493746,-0.10177267,-0.0075334883,0.06909082,0.05361168,0.05735457,0.07942839,-0.020714134,-0.020493027,0.0042668916,-0.031454217,-0.04692238,-0.07221915,0.13616848,0.0045736777,-0.074621186,0.03469156,0.08065822,0.031341538,0.025474139,0.020676648,0.083356544,-0.04314319,0.05094255,-0.04789297,1.6712396e-33,-0.007339215,-0.022658946,0.02075302,-0.02344587,-0.0048431656,0.040587682,-0.09259021,-0.03276486,-0.059383053,-0.031991486,-0.08799632,-0.050758637,-0.01285516,0.07921802,0.02496892,-0.011319447,0.007353261,-0.010173278,0.022432566,-0.012945823,0.0058214543,0.058897812,-0.026540529,-0.045490872,0.08983845,0.031464167,-0.00817123,-0.0073470296,0.04103001,-0.0094328225,0.057769477,-0.018325916,-0.008151528,-0.010184678,0.030274276,0.015994806,-0.005702806,-0.02515643,0.014760486,0.06500279,0.081071705,0.09783414,-0.019273585,-0.028717086,0.057280887,-0.08269337,0.022705292,0.045343254,0.029003656,0.028912822,0.035337526,-0.04238041,0.0906921,0.00782881,7.1648836e-05,0.0029579066,0.015649715,0.054024566,0.069842674,-0.011306597,-0.023786457,0.067116275,-0.023341672,-0.023146115,0.036212787,0.052550532,0.005143972,-0.0538137,-0.055491813,-0.0049712216,-0.101037465,0.030000066,0.08189683,-0.036503255,0.08996977,-0.06335999,-0.12647222,-0.029637355,-0.026195781,-0.009538499,0.047672175,0.009598131,0.024047924,-0.031240007,-0.037605874,0.0073694503,-0.025783619,-0.019852381,-0.018800536,0.017658634,0.033708345,-0.031377412,-0.03476458,0.03461547,-0.0029082375,-1.557986e-33,0.079571456,-0.034342524,0.06466902,-0.049402095,-0.052464057,0.1014953,-0.03219208,0.009983571,0.00471633,-0.038407527,0.07434768,-0.01241769,0.106404915,-0.0750061,-0.037866827,0.024083637,-0.019778274,0.05501153,-0.00050463766,-0.031854592,-0.08372373,0.043080118,0.05051267,-0.016527718,0.06206885,0.005486206,-0.014041287,0.11072289,-0.014271126,-0.07300162,0.0010165962,-0.050746385,-0.017054351,-0.06538925,-0.058478832,0.017154206,-0.03374703,-0.012698832,0.06295861,-0.0040157656,0.0011487381,0.014874135,0.084383905,0.005226013,-0.054934446,0.10858898,-0.052198682,-0.051335372,-0.05834326,-0.0046694963,0.027296482,-0.03880562,-0.021199534,0.046884418,0.06252039,0.07593335,-0.007436494,0.0622644,-0.01721806,-0.029401679,0.013880426,0.012077892,0.11568684,-0.0008058101,0.060700055,0.091262594,-0.09167679,0.10498214,0.012775199,-0.040427223,0.07116486,0.06788928,-0.020824198,-0.051015027,0.04846743,0.06208225,-0.11004013,-0.07716161,-0.042190608,-0.049660582,0.018800255,-0.03204984,-0.0669746,-0.101442926,-0.01774566,-0.025866827,-0.011078029,0.119943656,-0.013212498,0.093808,-0.049861748,-0.062286224,-0.017913725,0.020338807,0.08911608,-4.1090626e-08,0.024627557,-0.08040016,-0.00932117,-0.055079978,0.040917296,0.018096063,0.020399889,0.04553834,0.01765108,-0.013039156,0.055566758,0.046861473,-0.023825843,0.038673256,0.015279144,0.0045188623,0.012755925,0.015577655,0.008701665,0.0408995,-0.061640505,0.045751084,-0.10733115,-0.021698972,0.0017185087,-0.046070173,0.040294893,0.057406336,-0.09059386,-0.12105395,0.033677924,0.07053002,-0.036525268,-0.010858457,-0.123939976,0.008613437,-0.07561832,0.017568098,-0.032365795,0.05053082,0.0837863,-0.0020403527,-0.081993885,0.008312855,0.0018378977,0.018206928,0.01928654,0.07379133,-8.347468e-06,-0.023019155,0.018266097,-0.007486588,-0.04144382,-0.084561065,-0.13039647,0.0024009424,0.03261834,-0.03401089,-0.015312858,-0.04587715,-0.03455911,-0.10766439,0.15283923,0.045590706 +3.5.1.125,"The enzyme, found in bacteria, has no activity with (2S)-4-acetamido-2-aminobutanoate (cf. EC 3.5.4.44, ectoine hydrolase).",384,1.0,0.019357478,-0.08042971,-0.08201529,-0.035548512,0.07499245,0.03366493,-0.060867794,0.020207364,0.011994236,0.005925577,0.047342155,-0.12810607,-0.02946497,0.105684005,-0.054033212,0.040096007,-0.04251861,-0.09469364,0.048964642,-0.03059028,0.029692693,0.037226405,0.0013196635,-0.020739794,0.036815647,0.058506344,0.047409765,-0.04966131,-0.04719261,-0.08362663,0.00023148522,-0.06145054,0.05189711,-0.04032897,0.13421957,0.046150956,-0.012536523,-0.031370003,0.048136283,0.03981207,0.004772428,0.040470317,-0.0059462036,-0.039760984,0.0020314238,-0.023550266,0.020608272,-0.049105115,0.06342195,-0.013527518,-0.06696855,-0.05136705,-0.018668262,0.024069583,0.021024063,0.027850892,-0.0317598,-0.016288387,-0.070172705,0.025187448,0.060690377,0.0033515745,0.053728614,-0.009643366,0.0075552748,-0.005750005,0.0202523,-0.0801465,-0.018098759,-0.015042963,-0.050139315,-0.08026428,0.0129281245,0.09990755,0.014481701,-0.0703888,0.007896757,-0.053772,0.064311825,-0.031838395,-0.02887658,-0.11597203,0.009421628,0.07652543,-0.001339074,0.0071818545,7.295667e-05,-0.030530838,0.09348865,0.009767873,-0.0019736083,-0.0139583945,-0.0077225147,-0.10486913,0.0040862975,-0.015082532,-0.025307521,0.06679978,-0.03643401,-0.029891292,-0.021785006,0.05795473,-0.07169239,-0.083314456,0.0104054725,0.06922876,0.045238692,0.08454626,0.010031542,-0.0023398479,0.02822918,-0.034024402,0.07025012,-0.0008683369,-0.036437333,0.044627722,0.046461,-0.08472618,-0.09272416,0.044661265,0.023379898,-0.03485408,0.113220766,0.04814645,-0.059084993,0.08248152,-0.067386046,-1.4302145e-33,0.040112313,-0.0102283945,0.050668657,-0.055510208,0.030660272,0.021951023,-0.05998253,0.033757076,0.044483434,-0.0783486,-0.06367822,-0.052685436,0.0541641,0.009929011,0.07142043,0.032306205,0.034922283,-0.073590584,0.03350215,0.002297419,0.028057348,0.024222897,-0.043289494,0.03875802,0.0018852515,0.023951808,0.063103974,-0.008154922,0.050908245,0.016864594,-0.04769186,-0.043129254,-0.10208464,0.0062374384,0.05526209,-0.0049485187,-0.03359438,0.0047049783,-0.024338653,0.02542536,-0.007062141,0.06044181,0.019028328,-0.07958515,0.01682352,-0.1016462,-0.01127396,0.12892063,0.04525123,0.041951176,0.040347837,-0.023676872,0.08211724,-0.029498389,0.0055362904,0.06743161,-0.011876645,0.04789894,0.07198094,-0.00021814277,-0.0053923395,0.04618143,-0.037930064,-0.0073482953,-0.027408002,0.07963335,-0.036754638,-0.07768743,0.0002424725,0.045714717,-0.021331897,-0.003416644,0.05255532,0.05591168,0.03974302,-0.13341318,-0.038423926,0.0115737775,0.031382374,-0.009963481,0.047004756,-0.07040917,0.10163505,0.04955911,-0.026910296,-0.026417255,0.0015938623,0.040106058,-0.047604233,0.066687115,0.059791688,-0.035160694,-0.12957065,0.033084765,0.019774588,-5.4137833e-34,0.0724849,-0.0649163,-0.00831528,-0.057649598,-0.0806644,0.103859074,0.04524881,0.020468052,0.075843565,-0.014703663,0.15805453,0.026570823,-0.027481016,-0.08393808,0.0671314,0.0329085,-0.06834574,0.05285979,-0.009204225,-0.009500404,0.021354405,0.0156149715,-0.036818024,0.034879975,0.07361262,0.023119424,-0.028806167,0.057765216,-0.014621479,-0.0009197215,-0.026566058,0.02175794,0.004429852,-0.09828241,-0.061878234,0.014077241,-0.026586952,-0.030771604,-0.07505434,0.006739151,-0.021027671,0.06178117,0.0059275823,0.11221622,0.02763824,0.061802223,-0.0398726,0.026401337,-0.0489954,-0.038771827,0.0074410834,-0.08988537,-0.03560924,-0.03347879,0.07162481,0.046727363,-0.0065445565,0.03389838,-0.013238688,-0.023510832,-0.0021758832,-0.028904388,-0.019914055,0.015412138,0.07090502,0.044519898,-0.074310385,0.0731178,0.015885461,-0.03893049,0.059097115,-0.047885112,0.030216785,0.0050397892,-0.04179096,0.051200952,-0.112796344,-0.03290337,0.028608147,-0.07925889,0.017789183,0.033590287,0.027580492,-0.05802711,0.008959141,-0.083291635,0.028915051,0.067536816,-0.057470035,0.08026032,-0.052878868,-0.0061298497,-0.03889523,0.04338144,0.06549801,-3.4393807e-08,0.08316519,0.0010105071,0.06475831,-0.049595,0.007402303,0.025617927,-0.0003401984,0.018747395,0.09482705,-0.017800301,-0.067740045,0.051804665,-0.041470394,0.04817562,-0.008981891,0.013613998,0.01066594,-0.002577964,-0.07140276,0.021729266,-0.097108684,0.015198435,-0.12423083,-0.0105133895,-0.014748148,-0.03609303,0.020281056,0.027232893,-0.03528564,-0.08290179,-0.039728638,0.020459386,0.019964768,-0.049491163,-0.11850088,-0.010369524,-0.024147883,-0.03850175,-0.05790067,0.016352993,0.007730415,-0.0052580256,-0.040055748,-0.01564941,0.023220195,0.03937559,0.0026800216,-0.015560598,-0.047512367,-0.051464427,0.0372217,-0.011777742,-0.028341243,-0.024651138,-0.05445178,-0.004013325,0.00011474917,-0.08166366,-0.0045506693,-0.0673165,0.06396785,-0.016326254,0.13708635,0.04157348 +3.5.1.126,The enzyme has been characterized from the bacterium Klebsiella pneumoniae.,384,0.99999994,-0.09041204,-0.019011425,-0.11670141,-0.040943284,-0.034903593,0.09407579,-0.11155226,0.04086463,0.072840765,0.025208095,-0.028560963,-0.10231122,0.0077695325,0.059556667,-0.052783195,0.02277441,-0.083294936,-0.024885299,-0.0112205995,-0.06231325,0.04179278,0.08012055,-0.021702599,-0.02508254,0.021096028,0.011278183,0.056222185,-0.027308429,-0.03448452,-0.027021475,-0.005339097,-0.04706628,0.05918771,-0.049347613,0.09552461,0.02784237,-0.07629518,-0.044212904,0.10020568,0.00016351235,-0.010705068,0.0019997929,0.001238336,-0.03307495,-0.07934918,0.04495749,0.025486246,0.052031424,0.062240716,-0.026102478,-0.040516876,-0.1073371,-0.04745415,0.049972594,0.056759376,0.06465347,-0.08668397,-0.052355014,-0.024390427,0.046533477,0.009770006,0.028624183,0.039532,0.076956086,-0.03269797,-0.04043651,0.00079571997,-0.04899814,0.008662627,-0.06491879,-0.05028467,-0.123912886,-0.0045835413,0.11270954,-0.014525624,-0.020369615,0.004213457,0.040352404,0.031006552,-0.02386752,0.0055740788,-0.028877351,-0.026486197,0.08190037,0.03416995,-0.06003462,0.008656821,0.016407985,0.07282963,-0.029383447,0.064386494,0.0012306002,-0.047909763,-0.0652823,-0.057800405,-0.02756793,-0.04431479,0.062302776,0.0039711283,-0.020793995,-0.052502766,0.03750822,0.055327658,-0.10531346,-0.08633298,-0.0726916,0.053149547,0.04093587,0.06405621,-0.019440847,-0.01307319,0.009570482,-0.041593034,-0.04777288,0.06412103,0.020858577,0.08139475,-0.09771517,-0.08339591,0.02541209,0.008211857,-0.09602542,0.037138227,0.031375203,-0.041608147,0.084972925,-0.038072396,-2.5424648e-33,0.025921326,0.0016767675,0.06500183,-0.041370876,0.008029513,-0.09065326,-0.02075895,0.0026113482,-0.054140795,-0.07132756,-0.028066572,-0.044264287,-0.0114448555,0.009871125,0.023438174,0.051842224,-0.009779237,4.7602512e-05,0.030176064,0.05987373,0.09102335,0.020242242,-0.002568048,0.04300727,0.07531166,0.019418728,0.033217207,0.002383895,0.024868213,-0.020759936,0.014441786,-0.026802951,-0.11331857,-0.0170342,-0.032787047,0.033118825,-0.07797034,0.022238426,-0.020825539,0.07076705,-0.03136645,-0.031991664,-0.0068595633,-0.018573431,0.056638017,-0.020984361,-0.09621151,0.014522898,0.037526604,0.024888106,0.07836429,-0.025396196,0.1035177,0.009785038,-0.009594129,0.10596753,0.075549476,0.02629704,0.03992309,-0.024621947,0.03033957,0.07641205,-0.032678436,0.014621283,0.03491801,0.018747833,-0.051543035,-0.03928972,-0.04422865,0.07466259,-0.045677945,0.00477455,0.017761245,-0.030304745,0.024422094,-0.055545613,-0.07353518,-0.020709125,-0.008723129,0.031504948,0.022411466,-0.052501798,0.100445844,0.0061533,-0.07348936,-0.111620724,-0.007076367,0.04677814,-0.07125962,-0.03261084,0.058361184,-0.019768145,-0.084764816,0.07931923,-0.0054779826,-5.9733315e-34,0.13427737,-0.10352728,0.039705414,-0.026075514,-0.01835064,0.14631252,-0.013549845,0.06772863,-0.0008097781,-0.0021930165,0.10617766,0.010517939,0.008698257,-0.011135256,0.017080871,0.009449467,-0.0149069885,0.08236292,-0.020949883,-0.027329985,-0.008837762,0.07123667,0.044675037,-0.060159717,0.013665373,0.0024780936,0.0029239312,0.112070665,-0.044817265,-0.02525578,0.0340179,0.012661548,-0.028099446,-0.043709226,-0.053103503,0.051275693,0.010727432,-0.025997717,0.040446542,-0.024530629,-0.0036786054,0.06358189,-0.007743208,0.04636695,0.012250945,0.021054048,0.0008955488,-0.057974473,0.030730898,-0.08995299,0.02877501,0.034366664,-0.012880604,-0.0044831038,-0.05342156,0.059742942,-0.026520552,0.0058750333,0.032453988,-0.061896034,-0.07663542,-0.08137491,0.045346133,0.05057644,-0.006334457,0.01174829,-0.045450173,0.03952465,0.06490931,-0.014803254,-0.031033296,0.0054579154,-0.052589163,0.08271081,-0.025137167,-0.0052712657,-0.05878792,-0.016147822,0.008572041,0.0059449393,-0.024375498,-0.04578121,0.0029764585,-0.035860777,-0.004653019,-0.0854689,0.030250635,0.008978143,0.014286561,0.00926668,-0.026880711,-0.003202482,-0.080778226,0.06965519,0.013733805,-2.3098568e-08,0.07848183,-0.09510892,0.0055076173,-0.01541538,0.0469089,0.047398627,-0.057310518,-0.016907685,0.091445096,-0.06282789,-0.010214264,0.015679015,-0.039889157,0.07503376,0.0055223065,0.042803623,-0.093695246,-0.042904016,0.034966696,0.043556362,0.027986482,-0.0128221745,-0.061848357,0.065583006,0.045661494,-0.019929584,-0.03421676,0.044813834,-0.057941087,-0.0008320882,-0.06867321,0.07204566,-0.031381845,0.021460969,-0.060997166,0.020549811,-0.03040076,-0.039115075,-0.029005703,0.06597288,0.073282,-0.0398488,-0.06880582,-0.001016139,0.021292107,0.038576797,0.031334665,0.015187658,-0.0046326974,-0.10038358,0.01706722,0.005789358,-0.04066224,-0.023619415,-0.090271264,0.048625555,-0.00676304,-0.05587475,-0.014050039,-0.06741165,0.015210108,-0.021353811,0.1699365,0.046077553 +3.5.1.127,"This entry includes a family of enzymes that recyle jasmonoyl-amino acid conjugates back to jasmonates. The enzymes from Arabidopsis thaliana have been shown to also act on 12-hydroxyjasmonoyl-L-isoleucine, generating tuberonic acid.",384,1.0,-0.08204842,-0.075893275,-0.07785747,-0.021517294,0.014326878,0.09437882,-0.08670431,0.025021126,0.031030249,-0.007566701,0.07467478,-0.017095061,0.00035520692,-0.0482281,-0.016630484,0.057566304,-0.053001203,0.08099697,-0.07324208,-0.108619474,0.009651331,0.018711789,-0.008471619,-0.034762666,0.08528254,-0.043439914,0.0025888435,-0.057329964,-0.058764786,-0.0833783,-0.069514565,0.0024183432,0.05235164,-0.069455296,0.013827237,0.067019165,-0.018652387,-0.1080158,0.107634306,-0.010181585,0.011146162,-0.032048162,-0.031695746,-0.06174834,-0.021401953,-0.060839,-0.017645326,0.01580345,0.083014116,0.0077701686,-0.05626554,-0.016655521,-0.032741256,0.017645845,-0.032315087,0.021656064,0.0050770496,0.03675793,0.042388998,0.094716705,0.044908118,-0.031172678,0.020383636,-0.036127456,-0.039515372,-0.04392612,-0.047605123,-0.010537332,0.09908621,-0.06783842,-0.027973838,-0.06806312,-0.038633112,-0.0032038286,-0.08388963,0.04525578,-0.008436928,0.04987771,-0.02345034,-0.018772775,0.0012872298,0.001039651,0.008125215,0.028785223,0.00023395802,0.007361874,-0.08164429,0.033392254,0.06379993,0.12011918,0.019541297,0.003989404,0.039245993,-0.01568011,-0.061617523,0.05148444,0.06708444,-0.002224251,-0.023672432,0.024915459,0.038458087,0.019995885,0.0095208865,-0.06851244,-0.0884734,0.012548969,-0.050843105,-0.032510653,-0.034421027,-0.06318356,0.004041917,-0.04257234,-0.0043945084,0.027236123,-0.018488947,0.023648115,0.06549829,-0.015282565,-0.042680267,-0.07403276,0.023802148,-0.014419192,0.060636893,-0.023492262,-0.027175276,0.017744126,-0.1306652,3.7214542e-33,0.068841144,0.032483194,0.0035432684,0.005418003,0.0032904088,-0.04434371,-0.093173735,0.09470561,-0.018674368,-0.084261775,-0.07334907,-0.014408808,0.029974572,-0.074532256,-0.07060007,-0.018204112,-0.05975488,-0.053781204,0.038034182,0.027032387,-0.044181928,0.047392108,-0.04164495,0.004217607,-0.050490264,0.029366214,0.01213326,-0.05032346,-0.03216939,0.016534433,0.0046275747,-0.052036177,-0.022482755,0.03308281,0.08722804,0.032138836,0.0036434692,-0.024974104,-0.03787856,-0.0018279335,-0.02410045,0.08198106,-0.030541744,-0.008515051,0.048662245,0.0048858924,-0.016446032,0.030594716,0.07160608,0.06881881,-0.0016451768,0.027736388,0.13924411,-0.05211181,0.013877003,0.03923176,0.00031549408,0.05433882,0.012761845,0.10053998,-0.012193432,0.037220314,-0.013433863,0.067046545,-0.029123336,0.057158034,-0.121463545,-0.03625309,0.022437077,0.08556636,-0.039418213,0.011270631,0.038360532,0.03329137,0.069445945,-0.0928719,-0.0465396,0.006706282,-0.033078138,-0.033036277,0.05620029,-0.030296346,0.021020561,-0.014290943,-0.0025366372,-0.0044584163,0.0027569963,-0.0047037187,0.013787382,0.01199776,0.06466532,-0.011068118,0.0086501455,0.04337652,0.053162783,-4.294362e-33,0.09549505,-0.058286462,-0.007121839,-0.06307591,-0.028095037,0.02277918,-0.023114266,-0.076996066,-0.04638789,0.013670271,0.032027807,0.045664288,0.038521886,-0.019520085,0.0026302685,-0.018516991,0.07993738,0.018746495,-0.038024377,-0.02014446,-0.039615117,0.07208423,0.029500863,0.016731234,0.03545429,0.0037250353,0.018247774,0.07048882,0.011740301,0.07592454,-0.03423958,-0.027808918,0.014362584,-0.044739168,-0.0016546217,-0.010513236,-0.037321806,0.03552302,0.004089913,0.00353277,-0.028231168,0.053366367,-0.01744971,0.021527046,-0.014175647,0.027018705,-0.08533044,0.031884253,-0.069741555,-0.045843963,0.06669536,-0.003233254,-0.03550991,0.029150246,0.012542965,0.030545566,0.020660212,0.079322875,-0.008052941,0.0076330346,-0.07216864,-0.10735477,0.01628812,-0.039552588,0.083198,0.065674014,0.054254044,0.10693504,-0.019580364,0.0048162146,0.09806464,0.022842117,0.03268967,0.07683989,0.015335426,-0.061443407,-0.036494598,-0.07443373,-0.08447381,-0.032098062,-0.01005948,0.023570802,-0.02229694,-0.06669977,0.030202214,-0.081018925,-0.0007389862,0.110836856,0.013659385,0.09348023,0.031029621,0.003959587,-0.08776238,0.07902029,0.10355555,-3.401183e-08,-0.03623715,-0.007730061,0.022202088,0.029820178,0.0445966,0.0070121763,-0.04071071,0.040057436,0.04943906,-0.034337446,0.010397862,0.114801645,0.044716217,0.061108485,-0.016023725,-0.0051962095,0.0001572349,0.091901496,-0.023301333,0.08625445,-0.04117282,0.033617113,-0.10880202,0.0044181985,-0.0038676423,-0.0825695,-0.03517577,0.020699222,0.10219323,-0.03788359,-0.018267049,-0.0019335792,0.04668333,-0.12607132,-0.1587918,-0.034544475,-0.0014791483,-0.06352134,-0.012380668,-0.014562366,-0.025894191,-0.029531633,-0.073067375,0.03216555,-0.043184664,-0.03194755,-0.02490379,0.014488858,-0.005271289,0.066843346,0.058920473,-0.014759058,0.06542106,-0.09425273,-0.075544275,0.008072641,0.03967777,-0.020055786,-0.02159306,-0.0142171895,-0.0057225763,0.0047600367,0.19772469,-0.039865956 +3.5.4.44,"The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine. The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis. It also produces smaller amounts of (2S)-4-acetamido-2-aminobutanoate, which is recycled back to ectoine by EC 4.2.1.108, ectoine synthase.",384,1.0,0.008517589,-0.034612175,-0.0545953,-0.037397057,0.14281671,0.06061333,-0.04870073,0.06002417,0.03773171,0.008435233,0.008374576,-0.05000838,0.0017432829,0.04013761,-0.050360862,0.036258377,-0.061495714,-0.043446697,-0.03470528,-0.060731582,0.04148665,0.02544737,-0.05583816,0.022928856,-0.048811965,0.045149643,0.07874311,-0.07822576,-0.014401036,-0.12096941,0.028884964,-0.03540952,0.07414323,-0.048683457,0.08884738,0.064797536,-0.011302388,-0.074200876,0.086276464,-0.004853529,0.018424693,0.091514125,-0.009770243,-0.0923037,0.057538487,-0.023701238,0.050358918,0.013810696,0.073015384,-0.032126345,-0.006768654,-0.06539352,-0.025435863,0.0030847525,0.0071744802,0.0577386,-0.08828032,-0.03770511,-0.030027073,0.060294483,0.06332065,0.04740423,0.010761745,-0.040922847,-0.0070424154,-0.082531296,0.09151515,-0.09099183,-0.01153563,-0.018776694,-0.05762478,-0.08201769,-0.02076695,0.07961666,0.05101517,0.012353317,0.0056766095,-0.068532944,-0.02561601,0.004926247,-0.0047131297,-0.07146155,0.015139628,0.01991808,0.048065964,-0.027095763,0.05318138,-0.08453939,0.086975515,0.008437962,0.0213493,-0.076032534,0.022927813,-0.027100336,-0.020830397,-0.013025067,-0.0013002085,0.054817375,0.06388878,-0.0033650945,-0.014352135,0.054590706,-0.0885166,-0.078675374,0.019653728,0.045745254,0.07184324,0.124708034,0.06917822,0.029038697,0.0072940355,-0.043355707,0.031105774,-0.010190526,-0.0040426683,0.07676561,0.05293845,-0.025528291,-0.1119535,0.052619103,0.011921901,-0.0051304037,0.076250546,0.051461264,-0.040385507,0.10206177,-0.1003557,2.3390457e-33,0.042039,0.009297932,0.031846993,-0.04162883,-0.010011325,0.01340167,-0.07278342,0.025489064,0.021564951,-0.119852275,-0.09557955,-0.013263325,0.03033317,0.013789432,-0.040703356,-0.019229498,-0.03126032,0.0026621828,0.01875314,0.017905064,-0.062231056,0.043902386,-0.04387266,0.02597933,0.0337511,0.054954927,0.053326808,-0.013583263,0.059158523,0.01047723,-0.052597366,-0.009156257,-0.10327225,-0.0027492,0.033914212,0.036052186,0.012200508,-0.01505597,0.0033218558,0.049256746,-0.026340216,0.04915755,-0.02081681,-0.05107628,0.048540182,-0.08540229,-0.017633004,0.08656708,0.0510175,-0.008480894,-0.018207237,-0.040378638,0.10926731,0.0009897389,-0.023727966,0.020438524,-0.0017789919,-0.03160302,0.10593129,0.027195828,0.033951394,0.08176337,-0.04347959,0.037849043,0.027573284,0.034496035,-0.015869891,-0.029988213,0.013860998,0.054657377,-0.08429752,0.0059436304,0.03901511,0.06515283,0.03994689,-0.13950694,-0.09966856,0.039380085,0.03360327,-0.032041494,0.013299098,0.004321414,0.06973904,-0.018705023,-0.005040736,-0.057732597,0.004018739,-0.025478266,-0.013847885,0.08996159,0.030588118,-0.04916853,-0.049076926,0.047034446,-0.021990176,-2.7179059e-33,0.052215714,-0.05431833,-0.03841311,-0.024411185,-0.081671864,0.038542654,0.015402072,0.027829945,0.010536997,-0.020668756,0.03836871,-0.057678677,0.04594866,-0.07180147,0.027086727,-0.008015391,-0.021131929,0.01238491,-0.032853622,-0.044319555,-0.0060644196,0.0022096855,0.029657844,-0.013220334,0.042350747,0.022763675,-0.044539005,0.054666355,0.068029545,-0.02080784,-0.060212053,0.024234677,-0.009629186,-0.058487605,-0.08375133,0.04391224,-0.085946776,0.013753824,-0.0037733552,-0.016313002,-0.01854815,0.06068171,0.042122703,0.06531127,0.037000287,0.08672133,0.015418771,0.036552925,0.029432511,-0.073492944,0.05752085,-0.06578388,0.005238166,0.017453283,0.029526394,-0.015363916,-0.028781537,0.059651576,-0.047770534,0.039582048,-0.0028128233,-0.053329963,0.05365575,0.021663023,0.042146448,0.0144582065,-0.06592992,0.033167675,0.014264113,0.02353345,0.054225318,-0.03335126,0.053485144,0.03681383,-0.033407778,0.045267973,-0.1309168,-0.07766985,-0.010660548,-0.088100374,-0.013242907,-0.001279581,0.023919385,-0.05906168,-0.042304642,-0.10444135,0.010106864,0.07736013,-0.020687306,0.08183657,-0.050453056,-0.049562976,-0.028465755,0.016687619,0.045443464,-3.9784545e-08,0.037318647,-0.03889408,0.051734738,-0.0054442547,-0.02203131,0.03755683,0.029800024,0.03395776,0.09573176,-0.09349104,-0.059816755,0.0626977,-0.013121683,0.015242596,0.02087371,0.068620056,-0.030730465,0.00919977,6.675586e-05,0.052728064,-0.107025765,-0.0213466,-0.05675031,0.015241895,0.01951031,-0.028132483,0.05744959,0.08467643,-0.070207745,-0.05617097,-0.02274635,0.029299844,0.0028622148,-0.03547363,-0.076202184,-0.021258837,-0.08158976,-0.011155669,-0.0025351096,0.014092336,0.011754029,-0.0007642586,-0.12189206,-0.017183939,0.05718437,0.008415241,0.029999688,0.0034180752,-0.057386264,-0.03169702,-0.0013792757,-0.05520228,0.0042688604,-0.04836582,-0.050445303,0.015553327,0.0086910315,-0.08936689,0.03178397,-0.06815044,-0.013990864,0.0022920407,0.1904559,0.064313 +3.5.4.45,"The enzyme, isolated from the bacterium Acidovorax citrulli, performs the deamination of melamine 15-fold faster than the deamination of ammeline. It also has activity with 2-chloro-4,6-diamino-s-triazine, but has no activity toward halo-substituted triazine ring compounds such as atrazine (cf. EC 3.8.1.8, atrazine chlorohydrolase).",384,1.0,-0.025505232,-0.030547876,-0.116388425,-0.043477435,0.071880326,0.059749942,-0.033998683,0.056347676,0.040405132,-0.028025085,0.01154338,0.026992882,0.027927965,0.061640337,-0.057817023,0.101719625,0.07524375,-0.0029262868,-0.05648339,-0.0736694,-0.0057400498,-0.025634209,0.010878554,0.0032209111,-0.013208915,0.039647877,0.01591843,-0.028147336,-0.036940582,-0.101297975,0.032473244,0.035448324,0.06473006,-0.07460496,0.044596232,-0.00055061386,-0.06661034,-0.052904792,0.080560975,0.050049827,0.0051241103,0.063845366,-0.03218721,-0.079235405,0.0012609182,-0.04225009,-0.045796815,0.012713565,0.0510388,0.009351358,-0.010286269,0.00951441,0.035399206,0.022311766,-0.020547858,0.00018075111,-0.049839094,0.017753627,-0.075491674,0.061419774,0.07397461,0.022457719,-0.00018379586,-0.045894455,-0.02587805,-0.011468574,0.045930885,-0.10815156,0.07314879,-0.033614997,-0.040492296,-0.046718642,-0.0031832673,0.0007391566,0.024332419,-0.052649777,0.055334613,-0.029417245,-0.027916657,-0.02512209,-0.045113243,-0.05569829,0.033936873,-0.023395259,0.016585343,0.0036874628,-0.040318336,0.029047161,0.080742896,0.045462172,0.05992897,0.061238445,-0.0077925078,-0.088027164,-0.048264682,-0.01553135,-0.033438798,-0.031427413,-0.040613145,0.017993396,0.03760902,0.04033778,-0.10615066,-0.06976748,-0.0721651,-0.024723085,0.08436115,0.028302366,-0.017216286,-0.026150836,0.025379717,-0.023177842,0.09331525,0.02921098,-0.024530424,0.108055666,0.11087108,-0.009262522,-0.03623254,0.004923505,0.06381793,-0.019243699,0.05193191,0.04700162,-0.029300008,0.072192594,-0.1042438,3.148836e-33,-0.0073752953,0.059770584,-0.012006029,0.021032682,-0.07543257,-0.010428651,-0.07814479,0.047481198,0.012850362,-0.12195456,-0.04611613,-0.015381791,0.0500969,-0.087964036,-0.00412285,-0.042646438,0.088590674,-0.03415813,0.02375174,-0.048073202,-0.0038881814,0.09380792,-0.032184705,-0.009408004,0.037851203,0.065455884,0.04135781,0.0066299248,0.052544437,-0.008348676,0.014166353,0.004214887,-0.11356808,0.048068352,0.044794325,0.06365259,-0.04669744,0.031984434,0.021446232,0.082738586,-0.043348517,0.05139336,-0.021371592,-0.009799406,0.025202813,-0.05968998,-0.079652324,0.11567722,0.04564243,-0.0381794,0.016758826,0.02349377,0.034222443,-0.004764315,-0.061041433,0.080194466,0.0041301497,-0.0038256138,0.08489875,0.07273737,0.00084642094,-0.014440126,-0.12348979,0.017042398,-0.025871435,-0.003880888,-0.07009032,-0.027721938,0.028822932,0.094464704,-0.06715627,0.04495484,0.03194056,0.106818035,0.04906365,-0.07195941,-0.055262957,-0.009087798,0.06332291,0.026339509,-0.011361528,0.041732684,0.023629332,0.0035154112,-0.064596266,-0.020540312,-0.013020878,-0.0016708457,0.043186605,-0.00948227,0.038539756,-0.078043774,-0.012300725,0.024658162,0.032248218,-3.178002e-33,0.06980367,-0.069606945,-0.024615757,0.004034869,0.055793155,0.0729466,0.043194044,-0.0532479,-0.056983005,-0.045515772,0.076404326,0.00033988338,-0.013606925,-0.0015300665,0.10747395,0.05821817,0.062495906,0.036358934,-0.1020438,0.006059144,-0.07216614,0.03154363,0.013984791,-0.012660909,-0.09560733,0.044555902,-0.058943976,0.0011928165,0.053007122,0.05671611,-0.031762287,-0.0071386443,-0.05576077,-0.08719948,0.0036381984,0.106280275,-0.056931145,-0.03127834,-0.07486246,0.0050578783,0.0003310977,0.013308405,0.009679136,0.031051824,0.023560144,0.12250308,-0.08170063,-0.01675834,-0.05733293,-0.026399357,0.021988587,-0.052413743,-0.01379522,-0.052462775,0.06376599,-0.036681864,0.025182126,-0.05882153,-0.009521317,0.032736797,0.0016039237,0.023646662,-0.015347039,-0.03182091,0.005157908,0.01917936,0.06965977,0.10328812,0.06312011,-0.06079678,0.034099203,0.0038948033,0.056125846,0.025193661,-0.115565315,0.017953794,-0.045550704,-0.016577862,0.022988802,-0.079512976,0.008724418,-0.019223666,0.0031492263,-0.09724056,-0.04165412,-0.02613682,-0.0019535266,0.02756898,0.027999494,0.016399091,-0.025085736,-0.014538776,0.00031149335,0.090489626,0.04847103,-4.1898847e-08,0.059426658,-0.089053206,0.031636972,-0.014754971,-0.020064414,0.04707766,0.0011818554,0.061899424,0.033370923,-0.07498406,-0.016310912,-0.014118536,-0.0007469541,0.0373805,-0.023549158,0.050277803,-0.011481932,0.015855651,0.016043188,-0.01778166,-0.09286573,0.08079404,-0.110285625,-0.058525506,-0.03181821,0.018523455,-0.04239373,0.030732755,0.012173624,-0.04064164,-0.00708456,0.038671825,0.027429769,0.02537626,-0.073657155,-0.01829451,0.057040308,0.016116602,-0.010716639,0.04627758,0.048866946,0.054724514,-0.16020109,0.036060136,0.024544895,-0.0747679,0.039866798,-0.06789624,-0.027892167,-0.02404768,0.004887595,0.013897478,0.029004766,0.04163019,-0.047158893,-0.026126895,-0.021444961,-0.12041747,-0.057468813,-0.040660158,0.001244909,-0.07042162,0.12089031,0.0072993175 +3.5.4.46,"Requires Zn2+. The enzyme, isolated from the bacterium Leptospira interrogans, is specific for cAMP.",384,1.0,-0.08912288,0.014442632,-0.062228613,0.039756965,0.13126776,-0.00295369,-0.01007469,0.07754302,0.011902401,0.012399955,0.01259356,-0.060210474,-0.0495466,0.16768472,-0.017176371,0.044803604,-0.011151403,-0.010244029,0.043410942,0.030756433,0.08411388,0.06506121,0.02697599,-0.011171666,0.006835413,-0.015134728,-0.020331811,0.024902133,0.04374084,0.04519007,-0.0068378854,0.001098872,0.044924106,-0.04824573,0.0944055,0.052973803,-0.002096499,-0.05420229,0.04010706,0.016655466,0.0852325,0.041229367,0.0036234243,-0.038242113,0.013161893,0.035060257,0.0399151,-0.011133954,0.019887108,-0.021765448,-0.051767286,-0.051231544,-0.032101374,0.044269104,0.01905054,0.024652883,-0.13378543,-0.04589749,-0.024395186,-0.0009947361,0.0015966484,0.016433552,0.009986741,0.00781796,0.07438776,-0.041033607,-0.028077593,-0.012662764,0.047686234,-0.024587952,-0.044726305,-0.034539822,-0.013754646,-0.020782812,-0.056770556,0.0005456908,0.036892556,-0.040176876,0.031996664,-0.07089845,-0.031447526,-0.0203486,0.099268064,0.086401895,0.027258603,0.048262022,0.06493287,0.0034845462,0.0057465946,0.06264323,0.027566498,0.0034481157,-0.025407344,-0.050816387,0.012681737,0.038022615,0.03979458,0.021045815,-0.005186747,0.025092771,0.026206736,-0.010819993,0.0054572606,-0.10427907,-0.066141516,0.0029239494,0.09872567,0.0147897,0.020782309,0.031134333,-0.027009245,0.016277356,0.02619684,0.011716845,-0.030543867,0.064774595,0.022442222,-0.077733286,-0.06600212,0.09386784,-0.031104758,-0.11195793,0.04115581,0.06776076,-0.063351445,0.07800037,-0.08149856,3.1124377e-34,0.004180584,-0.0075929337,-0.05335705,-0.002826006,0.023725284,0.045734618,-0.077110045,-0.022984615,-0.056943793,-0.02669762,-0.12216088,-0.14217679,-0.0048568216,0.052692752,-0.017028583,-0.009815168,-0.014644584,-0.071484044,0.060092628,0.0019120565,0.06528649,-0.065275036,-0.0051528816,-0.021827914,0.112809286,0.07309522,0.046511322,-0.0278884,0.04595875,-0.014874441,0.0735929,-0.12843244,-0.06633164,-0.013742475,0.11557127,0.05451125,-0.0047585825,-0.05087628,-0.06340019,-0.03258372,-0.017238181,0.057520058,-0.023266193,-0.0072623603,0.130731,-0.020287724,-0.03466022,0.068846114,0.015043205,0.01141874,-0.01897466,0.022331983,0.0106031345,-0.06305479,-0.08416872,0.03518582,0.011636017,0.012867347,0.030339882,-0.0009038775,-0.017660784,0.052880485,-0.06916311,0.05946447,0.057358712,0.030569682,-0.08017871,-0.022984343,-0.011771513,0.0043695834,-0.052231465,-0.09909994,0.032244567,0.027356623,0.0031795648,-0.07913366,-0.027595961,0.06795787,0.07170707,-0.0051264176,-0.010600051,-0.071668275,0.010834655,0.019239707,-0.07437093,-0.06856194,-0.027398027,-0.028928006,0.0242076,0.04380852,0.080323026,-0.06563079,-0.020295963,-0.018358452,-0.011249833,-1.4450809e-33,0.010603252,-0.032167837,0.038525686,-0.059312377,-0.027821742,0.11327099,-0.05400154,-0.12747183,0.05555717,-0.0059183226,0.018308748,0.018835202,0.071462676,-0.044869877,0.029819679,0.012144439,-0.073894404,0.03823773,0.061008703,-0.014644007,0.00405999,0.084332235,0.038894,-0.0061760102,0.08391172,0.043925025,0.0043500476,0.15496992,0.03628422,-0.0070615876,-0.057959013,0.017303763,-0.054956414,-0.104879424,-0.053293254,-0.00850412,-0.017878527,-0.027660772,-0.09936576,-0.04571248,0.08779508,-0.029016504,-0.035429087,0.06982376,-0.030150548,0.052752636,-0.018343804,-0.030768158,0.026988741,-0.027641002,0.020492649,-0.056015372,-0.0976365,-0.04601167,0.06653155,0.019768374,0.0049181185,0.042471856,-0.045689497,-0.07136898,0.061695796,-0.04235128,0.017075483,-0.005035729,0.023843503,-0.00258646,-0.00084082264,0.09239856,-0.0033723302,-0.019745722,0.058182012,0.045002915,0.05775548,0.0005585041,-0.10408246,0.017689716,-0.06903798,-0.04789903,0.05186357,-0.102373056,-0.026528953,-0.03756258,-0.04186631,-0.028168518,0.06181162,-0.013222319,0.08342246,0.075766884,-0.036630906,0.0006205503,-0.011869228,-0.023431309,-0.011415128,0.045167044,-0.0579936,-2.8088687e-08,0.016525006,-0.06009521,0.04525347,-0.04271626,-0.020899609,-0.034963883,0.0124091,-0.039768767,-0.01343444,0.02274365,0.01458507,0.044578187,0.06264596,-0.0045027947,0.07360771,0.006802389,-0.033266615,0.017571267,-0.05175785,0.0036264881,-0.0835772,-0.020360094,-0.084632,0.072579,0.04572544,-0.08564067,0.019740023,0.07461671,0.04700646,-0.037680555,0.0037864924,0.017431203,0.017342709,-0.00966633,-0.11353609,0.07232245,-0.03664664,-0.08695752,-0.0069256127,-0.053510875,-0.030794222,0.031767055,0.04651354,-0.018908517,-0.053732798,-0.026921548,0.044431202,-0.024069812,-0.0219884,-0.027229862,0.032115005,-0.06321534,-0.0065326695,-0.0044516996,0.0011743652,0.0415573,0.014816009,-0.07083596,0.038651016,-0.044096753,0.004101611,0.00048044245,0.10168735,-0.041929033 +4.4.1.35,"A pyridoxal 5'-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-thiocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from Brassica oleracea var. italica (broccoli) does not act on cysteine or cystathionine.",384,1.0,-0.09480554,-0.07301228,-0.042246267,-0.02297747,0.07027029,0.060277503,-0.03364991,0.04573592,0.0031540627,0.062216286,0.035840463,0.008253918,-0.07389908,0.03895204,-0.078343876,0.08599816,-0.03305716,-0.015001614,0.024130957,-0.054419253,0.054167356,-0.0011922185,-0.029817015,0.04841363,0.08294519,0.06377589,0.0024148477,0.05370836,-0.0638421,-0.05848014,-0.09676978,-0.07700248,0.021785246,-0.077573255,0.0498301,0.1209243,-0.07401699,-0.024634704,0.07195306,-0.02526355,0.07916341,-0.036399722,-0.076994136,-0.030978581,-0.025200047,0.02514867,-0.020345142,0.06962691,0.02498765,-0.014696814,-0.073518045,-0.0024799544,-0.003227676,0.0023859737,-0.028765934,0.0012496709,0.00936091,0.029436741,-0.025006935,-0.003523513,0.022217467,-0.033264775,-0.039053485,-0.008006881,0.0076978067,-0.019617753,0.013127475,-0.07460251,-0.02184772,-0.004357627,-0.025219796,-0.07004888,-0.039602827,0.06519762,0.044778943,0.06903969,-0.04040128,-0.035186116,-0.00010010209,0.016215628,0.0025577783,0.024174638,-0.01277369,0.03213462,0.02545539,0.008802812,-0.0068662204,0.0006996167,0.037974365,0.00040998886,0.02292452,0.06470084,0.0061888434,-0.023572527,-0.00734727,0.024708932,0.05673812,-0.0012184397,0.03167036,-0.0400949,0.033463735,0.0113802375,-0.09965825,-0.13700674,-0.08047293,0.029693093,0.028981838,-0.01585095,0.014286069,-0.011432661,-0.054280445,-0.013400031,0.02147996,-0.013880846,-0.0365461,0.09917103,0.06104895,-0.028835757,-0.08857211,0.0095263105,0.010639828,-0.04089961,0.039183762,0.1418121,-0.12856998,0.027818082,-0.13753921,3.51252e-33,0.04705689,-0.0070160273,0.048688296,0.0069531617,-0.013016027,0.0033592465,-0.03402084,0.00024110895,0.00055157585,-0.03974103,-0.06834124,-0.02425799,0.034026362,-0.053532522,-0.03766509,-0.011503762,-0.01979258,0.03359372,0.074860245,0.034075476,0.06491223,0.03673324,-0.08140794,0.043929018,-0.0006807288,0.092575565,0.021322545,0.009837163,0.01737906,-0.011943143,-0.019263422,-0.09199865,-0.09579453,-0.031807005,0.07694428,-0.0995779,-0.046572354,-0.030082015,-0.028852152,0.05607016,-0.06783267,0.02678088,-0.0059213606,0.027863245,-0.0038153983,-0.058939353,-0.032470174,0.0416522,-0.010533854,-0.016652215,0.065306894,-0.0359826,0.10092906,0.011444052,-0.03449102,0.04639949,0.04208854,-0.0060164444,0.04234838,0.031873476,0.05075158,0.08294184,-0.020793816,-0.021153135,-0.062665775,-0.014782167,-0.07553101,-0.05227647,-0.021178221,0.081538945,-0.014517278,-0.004582935,0.006382416,0.03611384,0.02401442,-0.053499803,-0.0932655,0.033095915,-0.0019679035,0.024181698,0.044350587,-0.053009037,0.018334024,0.011593568,-0.06566757,-0.049863715,-0.036995508,-0.07114295,-0.040051624,0.06503349,0.06471314,-0.08801741,0.022954503,0.032720245,-0.0023382546,-4.6392288e-33,0.0992403,-0.057221852,0.030963253,-0.03718829,-0.05132416,0.05651786,0.00094802404,0.014899253,0.06375822,0.014551243,0.0639355,-0.030850653,0.00659916,0.027652113,0.036172137,0.055586647,0.039740592,0.097671136,-0.022691224,0.011265184,-0.048264176,0.0019703622,0.0065072123,0.05252718,0.049647424,0.04433861,-0.0050857733,0.04133924,0.0119022485,0.05888044,-0.033526387,0.033084445,-0.04879913,-0.06320111,-0.021220028,0.035263646,-0.04178605,-0.06909343,0.04966516,0.0437739,-0.009439256,0.026204653,0.07187148,0.098928265,0.004377066,0.010904236,-0.04889466,0.0410448,-0.04263433,0.010004827,0.08920087,0.03862478,0.0078303125,0.016970843,0.031776343,-0.007326174,0.037886277,0.0059028803,-0.010960768,0.028024586,0.028235417,-0.08784512,-0.030541644,0.03356055,0.014955968,0.06849114,-0.03723833,0.0017539477,0.0091650365,0.05908454,0.04538355,-0.03755487,0.051640406,0.02707814,0.0016751274,0.04197174,-0.00724853,0.03339451,0.041776076,-0.030775951,-0.009769484,-0.024641575,0.016946606,-0.13398774,0.00029288887,-0.101053454,0.023371994,0.0814659,-0.034737077,0.07482741,-0.023649931,-0.031750184,0.0015821713,0.104846664,0.110191725,-4.8539373e-08,0.075893864,-0.10169623,0.02740418,-0.02938514,-0.064175054,-0.039065033,0.059663497,-0.0407823,0.11428261,-0.09435018,-0.0064409026,0.01750042,0.04069597,0.030864328,0.048789363,0.011002175,0.009113632,0.049516045,-0.010696044,0.0021176976,-0.075743966,-0.032751955,-0.16168611,-0.024022276,0.0018429295,-0.080101974,0.045027312,0.045046084,0.003403883,-0.0030793676,0.024015717,0.03220264,-0.051166147,-0.05091498,-0.092368625,0.06733108,-0.09623336,-0.030111678,-0.0286244,-0.012903991,-0.05409897,0.042527393,-0.121865556,-0.0008244542,0.030325392,0.021198902,0.0015682038,0.009409285,0.03072139,-0.0029954726,-0.012320249,-0.014555708,-0.00032854488,-0.07444234,-0.055302605,0.049418256,0.08598165,-0.031260457,0.0017249312,-0.0988595,-0.04000466,-0.024659932,0.20130059,-0.0138671165 +5.1.1.22,"The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyses racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position.",384,1.0,-0.08793024,-0.0706942,-0.110740654,-0.05527429,0.003474248,0.09342327,-0.066921,0.03977057,-0.003847898,0.02905856,-0.004167902,-0.07667067,-0.028518021,0.011592013,-0.0933426,0.070010334,-0.06958594,-0.025851123,0.037628036,-0.0066753086,0.0026181382,-0.033499327,-0.031240517,0.02935772,-0.00030347417,0.023659183,0.032749444,-0.013728538,-0.02928742,-0.03329441,-0.02928419,-0.10160915,0.05334983,-0.022998683,0.05424674,-0.019207124,-0.06997976,-0.06485966,0.10830205,0.016220804,0.027372098,0.021126974,-0.06148843,0.018778073,0.057602663,0.0055105966,0.029286895,0.0881942,0.073344775,-0.111762986,-0.020956155,-0.045124512,-0.0710331,0.060149856,-0.011138472,0.058998924,-0.022724172,-0.006019277,0.049200114,0.05682519,0.044171218,0.049034175,0.009445322,0.00635207,-0.01764731,-0.028575731,-0.028501976,-0.006540941,0.035182655,-0.009220702,-0.06592754,-0.028202942,0.028179837,0.02668331,0.026149401,-0.03958539,0.0058702785,-0.026270613,-0.025350709,-0.054815453,0.017909043,-0.03599998,-0.041517373,-0.0073716496,0.014945346,-0.0022711167,0.064060315,-0.024670392,0.12752555,-0.01378135,0.013555589,0.015007913,-0.042880487,-0.025020234,-0.0762674,0.043194786,-0.024690785,0.012740832,0.11968312,-0.028974501,-0.037734266,0.028675122,0.01308359,-0.109391965,-0.059307557,-0.008496172,0.10028352,0.15775867,0.042436257,0.015435071,0.056010723,-0.0076859705,-0.001023287,0.11281135,-0.04671917,0.0322689,0.02167589,-0.076323494,-0.020709127,-0.030517029,0.014284393,-0.04767308,-0.019509373,-0.0009646885,-0.084354594,0.06274321,-0.047764678,2.763557e-33,0.059050266,0.017910667,0.046788935,-0.0033844057,0.0120178815,-0.012694698,-0.13485749,-0.015968796,-0.043382566,-0.026468433,-0.08010691,-0.0933143,-0.0024495702,0.09109834,0.063348696,-0.013813509,0.011990885,0.0016049749,0.031342577,0.032478675,-0.017688992,0.08758902,-0.01754245,-0.04331309,0.093127795,0.03299091,0.04661663,-0.008526145,0.03433154,-0.01723643,-0.0042315694,-0.10361185,-0.046450425,0.040143058,0.08154233,0.032353286,0.0059106722,-0.022894947,0.000381011,0.05569815,0.020288192,0.02413167,-0.016156858,-0.0026249068,0.05228174,-0.048630103,0.015110041,0.10463077,-0.017435066,0.07604935,0.013422381,0.024945127,0.076466575,-0.03720204,-0.003753773,0.05731746,-0.025167793,0.01782023,0.07893982,0.010661689,-0.010230043,0.04014119,-0.04290176,-0.020547811,0.057512145,-0.011153042,-0.051684644,0.004478594,0.013509571,-0.0020950332,-0.12964825,0.006177964,0.06504866,-0.042202402,0.029601498,-0.024490392,-0.052426554,-0.009974821,0.043404236,-0.116069876,-0.03655814,0.06318296,0.014014888,0.009975761,0.008841067,-0.023572078,0.0066064107,0.008006387,0.03247202,0.01798748,0.034109,-0.035764206,-0.067641065,0.06614703,-0.016708223,-3.28912e-33,0.05694638,-0.12543091,0.040048376,-0.04896108,-0.05973047,0.027287994,-0.010459924,-0.08865685,0.012489702,0.039031055,0.025834361,0.043710392,0.07662686,-0.041617893,-0.0035288986,-0.019115278,-0.013522386,0.04208248,-0.07554263,-0.07638446,0.105077416,0.053506836,0.023368709,-0.05542219,-0.011975634,0.008026976,0.0667338,0.15225029,0.0538089,0.029227681,0.0050908094,-0.0135010425,-0.021504993,-0.092000365,-0.050112832,0.075495645,-0.015693545,0.057123784,0.101575054,0.034511916,0.009940934,0.012129126,-0.07995435,0.017365556,0.0020071508,0.04369656,-0.01933343,-0.00746025,-0.009789554,-0.040789615,0.05172904,-0.08231408,-0.00535457,-0.041644607,-0.016820481,-0.023829466,-0.07261349,0.027447576,-0.025820633,-0.04542257,-0.026265109,-0.08318127,0.05051835,0.030546619,0.035568267,-0.01141571,-0.0011743855,0.009345012,0.047758408,-0.02784761,0.056728434,0.008767101,-0.08152823,0.038937878,-0.07688159,-0.058323026,-0.07170532,-0.107568905,0.0151095595,0.0488063,0.015956946,-0.0184641,0.003738544,-0.0807475,0.0040733363,0.03096852,-0.010764912,0.115688816,-0.0032903727,0.021452142,0.020851126,0.0037678138,-0.0037004538,0.08969314,0.060457956,-3.263869e-08,0.056842815,0.022248037,0.09568037,0.030750964,-0.040511154,0.032790434,0.019121895,-0.04434134,0.06393848,-0.09492482,-0.017508155,0.013121045,0.0007466858,-0.010437126,0.03809008,0.043274865,-0.049536616,-0.0677746,-0.044816095,0.015734464,-0.043799266,0.005919081,-0.09816729,0.08310041,-0.0331005,-0.093299724,0.0451461,0.017113408,-0.06968241,-0.01452328,-0.013875772,0.07871716,0.038711645,-0.07844176,-0.013675359,-0.0009552935,-0.011216504,0.045440793,0.024848858,0.044978533,0.05890183,-0.024920112,-0.07042715,-0.007664448,-0.040069558,-0.006256474,-0.023175519,0.059186995,0.0057389042,0.01698408,0.08530065,-0.028084356,-0.056772683,-0.05855139,-0.0938668,0.066578716,-0.06835114,-0.011120938,-0.025459116,-0.031665605,0.0053724544,-0.019967409,0.14456019,-0.021142261 +5.1.2.7,"The enzyme, present in bacteria, is involved in a degradation pathway of D-galacturonate.",384,1.0,-0.040084347,-0.124465294,-0.005302374,-0.009633522,-0.0023627295,-0.0011038951,-0.024538103,0.045250807,0.017839465,0.046453893,-0.016796624,0.0354007,-0.043986402,0.08307601,-0.105359636,0.03160873,-0.07546056,0.042176366,0.010785172,0.04944164,0.1308679,0.038401168,0.006165155,0.0021599645,0.0899832,0.0005779812,0.07811041,-0.0806044,-0.0668333,-0.051783986,0.018578263,-0.02642871,0.053798985,-0.02195262,0.02060994,0.11106273,-0.013036395,-0.059517395,0.06693343,-0.033060066,-0.00093765126,0.038963623,0.017156387,-0.010439995,0.026988056,0.062292114,-0.032699917,0.041710638,-0.004676808,-0.030896397,-0.02532292,-0.058716193,0.004372653,-0.020887485,0.06158884,0.10240745,0.0040685353,-0.07731868,-0.007805921,0.015480703,0.095345855,0.05835242,0.046244428,0.011214101,0.010120419,-0.08838725,0.04216763,-0.020393847,0.016088527,-0.014009943,-0.055208668,-0.08160966,-0.043932125,-0.0303368,0.046924334,-0.019920997,0.020632552,-0.06912969,0.0562103,-0.08707299,0.06505538,0.01916749,0.034337655,0.042768143,0.01241771,-0.030334288,0.09384459,-0.022146102,-0.010056912,0.011531685,0.006187991,-0.06147859,-0.06576883,-0.04766338,-0.0717721,-0.041449208,0.012645184,-0.014238395,0.05385359,-0.028103733,-0.03853714,-0.0009036619,0.027905382,-0.056052364,-0.028400633,0.015216263,0.004852794,0.08167465,0.050655663,0.011107742,0.026667533,0.010174426,0.009111353,0.03958893,-0.03725726,0.07402441,0.043142088,-0.009035768,-0.07325405,0.038355242,-0.03637707,-0.055447273,0.04214956,0.003609338,-0.05747966,0.04907966,-0.042500135,-4.608623e-33,0.059734136,-0.059886236,-0.03262669,-0.062469408,0.019797413,-0.009705484,-0.060311504,-0.035975106,0.03258108,-0.066466175,-0.062033266,-0.09314212,-0.01074936,0.04521839,0.00386132,0.07744019,0.0076519,-0.025070421,0.0050663524,-0.040836055,-0.0116105005,0.062310804,-0.047130242,-0.020113159,0.07962455,0.012344174,0.021402868,0.070888236,0.08277427,-0.012037696,-0.0051120967,-0.08965898,-0.088410385,0.007503623,0.059145678,0.07903057,-0.020817975,-0.033686023,0.016534535,-0.032010533,0.008981088,-0.010078657,-0.021374602,-0.016224207,0.0014644852,-0.015414023,0.0081888465,0.08776175,0.013305947,-0.007145376,0.03968351,-0.055564083,0.03126567,-0.0167672,-0.027102103,0.052057333,-0.0522496,0.011705401,0.069743745,0.02258325,3.6412614e-06,0.037736118,-0.058980368,0.07780591,0.044699743,0.035249185,-0.027751403,-0.014247293,-0.016942982,-0.005025086,-0.09111634,-0.08128258,0.016851587,-0.019024294,-0.071270086,-0.041100334,-0.027777398,0.0034203578,0.040182367,-0.052266125,-0.012686285,-0.0045875367,-0.026706854,0.010298885,0.021405634,0.04812403,-0.013381844,-0.052214947,0.00124528,0.071127445,0.01734336,-0.054310646,-0.052226145,0.04058446,0.0022442346,1.1430253e-33,0.020679345,-0.060878377,0.08577097,0.036665205,-0.058583695,0.10441691,-0.04117135,0.032287877,-0.003641702,-0.09623295,-0.022369323,0.023438467,-0.036487516,-0.08797231,0.018060263,0.002340162,-0.026883086,0.040671747,-0.093983576,0.014226161,0.03412341,0.11721747,-0.043669607,-0.031797685,-0.016872779,-0.0047158333,-0.04396244,0.083490394,0.032703694,0.030564252,0.058486808,0.029431578,-0.045655865,-0.06271308,-0.042388633,0.03081834,-0.024345018,-0.027872445,-0.019647779,0.021392712,0.009189625,0.0629594,0.043522917,0.06666489,0.09680258,0.06456442,-0.06745342,0.01909899,0.076473214,-0.017649718,0.016830485,-0.09249438,0.026386118,0.018713182,-0.03200632,0.041449185,0.06279433,0.046084225,-0.008758476,-0.02684026,-0.055499308,-0.10095466,0.120318145,-0.041573565,0.035313275,-0.015274293,-0.008523824,0.109420344,0.05491599,-0.07405215,0.08621065,0.05738184,-0.015672846,0.026014343,-0.059070867,-0.004826587,-0.15945357,-0.02153421,0.0540025,-0.006214749,0.065776706,0.06915242,-0.029489994,-0.022380916,-0.0025514422,-0.05432505,0.059016414,0.12846686,-0.010449487,0.00442511,-0.061482895,-0.033426557,-0.049593456,-0.012538958,0.023831015,-2.0885183e-08,0.09158711,0.018304912,0.033093452,-0.086784385,0.01750949,-0.05417558,0.017682564,0.0756963,0.0628478,-0.053603243,-0.048161484,0.121033885,-0.060668416,1.7264336e-05,-0.01737225,0.050745662,-0.03443677,0.014571564,-0.047796823,0.023933684,-0.062142283,-0.04522548,-0.070525974,0.0605964,-0.010057296,-0.054442488,0.09050439,0.08911354,-0.054141406,-0.065988556,0.036889747,0.07004045,0.030447975,-0.006434493,-0.1201204,0.0057359193,-0.026821258,-0.04050385,0.041759778,0.07745497,0.00046902036,-0.0046190917,-0.014734589,0.00041620765,-0.082272574,-0.0010027686,0.011562874,0.04217924,-0.08767103,0.04443313,-0.01072509,-0.020674847,-0.09338861,-0.058013376,-0.11473336,0.0009145363,0.017654836,-0.03410649,-0.014550793,-0.07144841,0.011569194,-0.054899555,0.13463482,-0.017930148 +5.1.3.40,The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways.,384,0.99999994,-0.032943442,-0.1329578,-0.053786956,0.032644488,0.03040739,0.024264202,-0.09040472,0.058201153,0.05244987,0.015338898,-0.034721464,0.01492088,-0.0008658517,-0.045761034,-0.065789044,0.03421366,-0.037744243,0.022441218,-0.0574488,0.021135686,0.07795259,-0.005078612,-0.05579832,-0.07546865,0.06577746,-0.0038651868,0.018786313,-0.036113888,-0.0941751,-0.08792712,0.024962688,0.013046689,0.12638284,-0.01813204,0.026700988,0.091862366,0.010978576,-0.014028554,0.0981239,-0.059813138,-0.016809644,0.0110217035,0.04433936,-0.008471326,-0.0027871544,0.027282069,-0.04925241,0.01963002,0.056733824,-0.026531607,-0.035161972,-0.05415558,-0.021481933,0.010090478,0.05512032,0.093268774,0.020819899,-0.1272221,0.032046154,0.061272725,0.03989109,0.0006265892,0.010584979,-0.008220371,0.027419887,-0.055009153,0.01865135,-0.07302387,0.0084787,0.02893198,-0.11077914,-0.044585567,-0.0065656654,0.014043637,0.020663925,0.03233014,-0.044112206,-0.022217369,0.1068615,-0.040152706,0.0473511,0.04575054,0.034451425,0.03365128,-0.021685632,-0.032610767,0.083452374,-0.03436384,0.081239425,0.016884753,0.0456775,-0.0034634492,0.010330143,-0.061183173,-0.045304347,0.027623609,0.02570398,-0.052581027,0.012544696,-0.030993683,-0.009895978,-0.012184213,0.042255957,-0.043253604,-0.071889125,-0.033600673,-0.04422989,0.1547907,0.0073169935,0.005948598,0.013290714,0.014298267,0.0025535226,-0.06954378,-0.06132574,-0.008983282,0.05261184,-0.05572563,-0.058208805,-0.02638968,-0.03878572,0.0039336584,0.044703566,0.014422271,0.055601005,0.006849488,-0.041216552,2.0441742e-33,0.06307392,-0.05491584,-0.012031621,-0.043451805,0.03770253,-0.022847652,-0.06325495,-0.004796843,0.056099143,0.0141833555,-0.036495358,-0.04835089,-0.017474407,-0.07826707,-0.008807851,0.1112686,-0.01267115,-0.0473965,0.008491741,-0.036021806,0.031486236,0.037083805,0.005565475,0.00090651686,0.04457787,0.061905395,0.053005356,-0.020920513,0.043795273,0.015089789,0.011006668,-0.038232785,-0.1082555,0.0146169765,0.06329445,0.035610016,-0.045673486,0.0034608024,-0.044412233,0.055833038,0.0365713,0.042863984,-0.022427484,0.018076213,0.06030862,-0.036907673,-0.0066008097,0.11413579,0.05878986,0.11035576,0.059387796,-0.07195742,0.07091378,0.028872887,-0.002760843,0.028009124,-0.0841528,0.05985937,0.028350178,0.030096447,0.0097407475,0.05781632,-0.008329294,0.061283167,-0.014891038,0.019803273,-0.08046466,0.036696006,0.031289324,0.07771738,-0.011966488,-0.033771574,0.014291002,0.050391465,-0.0364064,-0.058380228,-0.05782807,-0.04137324,0.04354282,-0.020323213,0.0054330216,-0.016379971,-0.018607989,-0.005566615,-0.039780352,0.0019482628,-0.08507669,-0.054339465,-0.030587975,-5.6807785e-05,0.05713607,-0.05011071,-0.09146753,0.1222638,0.0020860308,-3.102029e-33,0.09170609,-0.11098199,0.09865365,0.006018431,-0.018486999,0.026413506,-0.023825709,0.020345535,-0.030034596,-0.034317743,0.020482974,0.053667676,-0.0074492204,-0.026951218,-0.007878385,-0.022119803,0.022751518,0.019240292,-0.08268538,0.013136903,-0.061106715,0.06330275,0.02594664,-0.015647776,0.025794355,0.020903045,-0.0068506333,0.107439734,0.038150437,0.033690512,0.074505545,0.063510545,0.0009049917,-0.03777195,-0.090802535,-0.005731946,-0.034188356,0.00031893668,-0.0003300434,0.017144725,-0.016922047,0.05739813,-0.0037735743,-0.001452067,0.06608304,0.022002121,-0.06305259,0.002136885,0.08949049,-0.07448656,0.0395628,-0.09664103,-0.01130105,0.016888347,-0.03851135,0.055022836,0.07068279,0.017653184,-0.03710141,0.0027067622,-0.02124018,-0.034532897,0.09487303,0.0052894526,0.10360216,0.08527489,0.06041176,0.14654565,-0.031847373,-0.03267794,0.06499522,0.034384247,-0.025415517,0.02725747,0.05152923,0.03355993,-0.07335176,0.015890686,-0.006248144,0.019238831,0.033067085,0.012997345,-0.025027283,0.0035724046,-0.075250104,-0.038676128,0.023890994,0.0858653,-0.033854757,0.039377004,-0.11859954,-0.009604957,-0.030997746,0.037118297,0.07741228,-2.6598578e-08,0.03561645,0.03141382,-0.0095326295,-0.07883785,0.044593852,0.04351936,-0.0900223,0.051895175,0.054052383,-0.05551103,-0.10821369,0.11641894,-0.07658234,0.045183208,0.013824294,-0.018464388,-0.039934713,-0.048262913,-0.018405637,0.021118471,-0.09100456,-0.050440367,-0.056074757,-0.0062548425,-0.017412737,-0.06813269,0.053065076,0.037435453,-0.028775236,-0.02497194,-0.021616753,0.025495306,-0.02272321,-0.0222585,-0.109945215,0.0322157,-0.01340728,-0.13769133,-0.013035699,0.0695762,0.023618035,0.009369437,-0.07002713,-0.02022177,-0.0779453,-0.018896228,-0.025750145,0.027976662,-0.06199796,0.021659194,-0.003048209,-0.02131074,-0.1214829,-0.035664853,-0.071170144,-0.01077357,0.038570855,-0.0710477,0.00946739,-0.0081461845,0.0044410923,-0.0803922,0.08017737,-0.019410932 +5.4.99.64,"The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, uses radical chemistry to rearrange the positions of both a methyl group and a hydroxyl group. It consists of two subunits, the smaller one containing a cobalamin cofactor. It plays a central role in the degradation of assorted substrates containing a tert-butyl moiety.",384,1.0,-0.032091644,-0.025706535,-0.085481636,-0.024743307,0.010589324,0.03334765,-0.050258234,0.05298239,0.048874136,-0.051226616,0.03714115,-0.010551706,-0.02182263,0.053085703,-0.072533526,0.03420055,-0.060005,-0.017418133,0.028526217,-0.050652657,-0.0471901,0.037926923,-0.0141908685,0.031291187,0.06629739,0.02233612,0.020890791,-0.030280448,-0.037825305,-0.030273922,0.036835413,0.07718231,0.04366619,-0.00577071,-0.051700614,0.097290255,-0.035408203,-0.053805992,0.07793856,0.008183426,0.044840813,-0.00813138,-0.06606108,0.025524855,0.023168812,-0.028856505,0.041847926,0.08198598,0.049871564,0.012889153,-0.040462386,-0.033865232,-0.0699232,0.095129095,-0.04926607,0.035357118,0.047452085,0.012344032,-0.014724252,0.019388443,0.0838994,0.034972277,-0.01541996,0.0561809,0.0046512187,0.005693941,0.035829023,-0.048765674,0.017105168,-0.008698669,-0.02725146,-0.08648659,0.021435034,-0.010757759,-0.014552586,0.009255823,-0.010978254,-0.07439669,0.017815268,-0.028917653,-0.0023708704,0.0067013116,0.058948033,0.09584729,0.078454904,-0.052474573,0.021283405,-0.033427566,0.082169406,0.009352933,0.0018924718,0.04446844,0.018882727,-0.046770044,-0.059145097,0.01635056,0.028752308,0.033510786,0.050183304,-0.031475823,-0.014620644,0.04171647,-0.017668927,-0.103331834,-0.10089193,-0.027109167,-0.02029662,0.109018825,0.100528866,-0.0028823663,-0.026921025,0.013537618,-0.0041880575,-0.054359995,-0.010058788,0.07477048,0.073168926,-0.020742359,-0.11053835,0.016125958,0.014793545,-0.02266829,0.043644294,0.022699608,-0.06527777,0.027104478,-0.13699962,1.0848608e-33,0.065121114,0.014318437,-0.038426228,-0.010274183,-0.0016094377,-0.010595198,-0.08825813,0.03828342,-0.07053189,-0.03430516,-0.023263413,-0.037944734,0.017660413,0.048999287,-0.02109097,-0.04631957,-0.0005701597,-0.010726448,0.031559236,-0.0004414204,-0.055972688,0.11774611,-0.05395158,0.019369714,0.021074126,0.07215944,0.033480637,0.073058836,-0.031410765,0.018065877,-0.011793844,-0.09148157,-0.2005806,-0.020572534,0.09823848,-0.0081771035,-0.07502224,0.0053894916,0.010418235,0.05059361,-0.0036868148,0.07887587,0.03304619,-0.023422167,0.07784535,-0.045143735,0.008115764,0.13616922,0.02600159,0.043940634,0.006734039,0.020551994,0.07337196,0.0039306837,-0.066231474,0.020216087,0.03394683,0.056232832,0.0139960395,0.010005065,0.048184324,0.013813739,-0.046340734,0.07617395,-0.03238701,-0.005549529,-0.05812712,0.011289311,0.030667383,0.037296496,-0.084518455,0.057674833,0.046855178,-0.011499246,0.02824822,-0.041420743,-0.026800325,-0.04199248,0.04827471,-0.07811013,-0.08644557,-0.051656615,0.04433073,-0.051635105,-0.1135253,0.014723957,0.031632736,0.028210243,-0.05065609,-0.01666465,0.025894731,-0.004870799,-0.03774563,-0.02102038,0.05474351,-1.3524812e-33,0.040590055,-0.09208379,0.0042959806,-0.09683891,-0.049183708,-0.013153246,0.012579762,0.0030893988,-0.0018840703,0.003707848,0.091644436,0.019565938,0.010126737,-0.05176658,-0.022029938,0.074403845,0.037247512,0.079562426,-0.04691033,-0.07215264,-0.0017599078,0.045324557,-0.015307609,-0.05347299,-0.042477053,0.06787998,-0.0020457448,0.0087397015,0.11390991,0.07163152,-0.04149985,0.0052111303,-0.017595826,-0.0598559,-0.009842367,0.08174383,-0.034734838,-0.008606356,0.019371916,0.00418475,0.082951605,0.031576786,-0.015530179,0.07545734,0.051868908,0.06749961,-0.068271734,0.025321491,-0.015512833,-0.036086258,0.10064826,-0.01249112,0.036391944,0.001570903,0.031381987,0.015093709,-0.0015000366,-0.07035481,-0.043328222,-0.099854134,-0.010132199,-0.06616024,0.045148734,0.017420137,0.009481454,-0.008499043,-0.02659819,0.042496428,0.024288874,-0.020209102,0.076331936,0.052377958,-0.027489673,0.03153531,-0.050623268,-0.04870364,-0.052038513,-0.017449992,-0.02601214,0.0028659033,0.02209186,-0.057394028,0.006351338,-0.09535995,-0.004672642,-0.050912052,0.0058442256,0.11629485,-0.025245424,0.058522392,-0.05050668,-0.00010881322,-0.07642281,0.04424788,0.104814574,-4.157635e-08,-0.00052246626,-0.09472858,0.029236153,-0.033618465,0.03332446,0.09807875,-0.010791761,0.024363857,0.0645687,0.006902286,-0.0027106507,0.08119901,-0.02994335,0.069863714,-0.018795762,0.01742005,-0.009690598,-0.034483343,-0.04097084,0.0045518624,-0.05134022,0.010969062,-0.07593481,-0.0026447703,-0.0018731992,-0.042586666,-0.050672423,0.019742396,-0.044240974,-0.0539528,-0.01786129,0.06993652,-0.027512092,-0.025157025,-0.1219895,0.02718305,-0.04389125,-0.012351554,0.0038615623,0.08089518,-0.03228862,-0.022435581,-0.122992426,0.0670297,0.026056645,-0.05708495,0.045828108,0.029399576,-0.046015073,0.020222804,0.038779683,-0.02682208,0.0156032145,-0.04092238,-0.101671465,-0.0043706563,0.0026726075,-0.047319826,-0.036009625,-0.09033887,0.02082174,-0.0023103254,0.17695098,-0.1011916 +6.2.1.48,"The enzyme, originally characterized from the bacterium Escherichia coli, can catalyse the transfer of CoA to L-carnitine, crotonobetaine and gamma-butyrobetaine. In vitro the enzyme also exhibits the activity of EC 2.8.3.21, L-carnitine CoA-transferase.",384,0.99999994,-0.1091633,-0.07614137,-0.0102133695,-0.0058021746,0.04274611,0.070367716,-0.07414269,0.06294984,-0.0014058818,-0.03508292,-0.015546873,-0.09718048,-0.026396317,0.05505065,-0.041230425,-0.009240241,-0.01575013,-0.019875351,0.009705224,-0.040647034,0.048604287,-0.03216684,-0.038666904,0.047813226,0.068381615,0.041087646,0.008831747,-0.0524736,0.015545507,-0.0549101,-0.03525502,-0.10259743,0.02757905,-0.03574482,0.039138265,0.052216016,-0.035467368,-0.11362078,0.026984083,0.007228415,0.02584864,-0.0672608,-0.032004792,-0.05147721,0.0030349272,-0.08892192,0.045092907,0.0030534775,0.00070883264,-0.056858417,-0.019615088,-0.07449074,-0.06746231,0.0315041,-0.032713857,0.056052793,0.0070778094,-0.022728248,0.05222097,0.08044171,0.016087491,0.05494212,0.036528464,-0.0048548235,0.038648132,-0.10156435,0.031411767,-0.0022068936,0.008135453,-0.019879114,-0.0354796,-0.06246984,-0.075832516,0.043536067,0.026544427,-0.03649409,-0.009001053,0.035119537,0.0033427961,0.011862573,0.026395952,-0.02171404,-0.033842795,0.074054606,-0.00068075064,0.008678882,-0.0072003636,0.020252781,0.0472978,0.025774753,0.007950367,-0.008225266,-0.009861919,-0.025281457,-0.07786085,0.03275837,0.023489024,-0.0039229738,0.09345296,-0.02775231,0.026823957,0.11196647,-0.083666556,0.0012501002,-0.05143042,-0.025097597,0.029237188,0.077494994,0.027145509,-0.06539464,0.033679463,0.01816062,0.020625439,-0.004073818,-0.028541125,0.105339885,-0.029616755,-0.031838465,-0.007145296,0.060524985,0.034422997,-0.041552555,0.0062600547,0.042962234,0.043723553,0.050065596,-0.09278692,1.1077445e-33,0.04069474,0.05704515,0.01548432,0.027885348,-0.003843049,0.0023035682,-0.10300382,0.087023795,-0.02416598,-0.067528106,-0.05106132,-0.034065027,0.058113225,0.051201954,0.0011120797,-0.0032675227,-0.01691994,-0.046627045,0.029216351,0.010472853,0.006258997,-0.048185498,-0.00044146276,0.10518201,0.005337222,0.052037213,-0.049231987,0.063756995,0.08672913,0.009927645,-0.032773808,-0.0406866,-0.05241704,0.019673627,0.040953293,-0.06152883,-0.038539413,-0.017714119,-0.0074327835,0.07553031,0.091896586,0.049400344,-0.04763113,-0.029188793,0.0492285,-0.061330117,-0.03294492,0.053104382,0.04016283,0.041949347,0.061812896,-0.055193543,0.047720257,-0.10877608,-0.05560003,0.12719388,-0.04846962,0.0023267304,0.0065478436,0.0019606438,0.028973209,0.12204554,0.023664823,0.017713135,-0.0015007366,0.08546166,-0.04875348,-0.064908154,0.020549621,0.03437523,-0.11005402,0.02440023,0.046376094,-0.0093647335,0.10056472,-0.062252183,-0.10424649,0.019020936,0.06913145,-0.047352973,0.033025835,-0.02768681,0.077162534,-0.028342012,0.012507158,-0.05405299,-0.03172433,-0.038130354,0.00053935475,0.11373561,0.059810974,-0.0750555,0.018186085,-0.03189947,-0.03543803,-1.4335594e-33,0.09920808,-0.09800329,0.01741412,-0.10740922,-0.06509939,0.084018104,-0.020443782,-0.05972866,0.0756145,0.027859148,0.08567743,0.064048626,0.05158965,-0.05491677,0.02161723,0.006121843,-0.009767718,0.021209214,-0.0612371,-0.008188701,0.022378096,-0.014590748,0.05692996,-0.024101187,0.0933946,-0.0023615519,-0.04401571,0.06558474,0.12623437,-0.019962493,0.022748316,-0.05175484,-0.024696343,-0.04797455,-0.038173117,0.0470472,0.030481525,0.027963897,0.032287613,0.002111395,-0.019312639,0.00022785673,0.044385225,0.030925464,-0.01512512,0.054616466,-0.038538426,-0.060630832,-0.0336216,-0.021696804,0.030692497,-0.023006078,-0.06807968,-0.0145933805,-0.0030266051,0.03121065,0.0005802326,0.013652086,0.0013795908,-0.042608663,-0.0046069566,-0.016585939,-0.041667655,-0.019668587,0.0675315,0.014783653,-0.047238685,0.046760056,0.0010744917,-0.03192207,0.1308274,-0.017970428,0.030564833,0.010332477,-0.05167923,-0.0045068986,-0.058720388,-0.054956995,0.01128944,-0.0908951,-0.012597809,-0.009082099,0.0053827246,-0.07939188,-0.019769475,-0.062137824,-0.023566896,0.11401238,0.06927038,0.020040415,-0.043103695,-0.039732773,0.03687517,0.023780499,0.0965793,-3.4012288e-08,0.0326604,-0.1052168,-0.048125338,0.010623288,0.052804157,0.04425248,-0.081767045,-0.03696213,0.039160892,-0.033874318,-0.05577581,0.056209423,0.057045277,0.00570818,-0.031534176,0.0019277198,0.06509443,0.012653131,-0.0057866764,0.05128283,-0.034169056,-0.0011821385,-0.05794319,0.03148159,0.029220218,-0.10765754,0.011884668,0.06623197,-0.014907623,-0.05452946,-0.018737245,0.041091878,0.04400405,0.002525495,-0.051088743,-0.0384598,0.010932497,-0.014989644,-0.040644404,0.01256344,0.118331335,0.0022820625,-0.12796842,-0.002064204,0.025854968,0.05301775,-0.016863363,0.0004193009,-0.028048329,0.020675099,0.0705199,-0.028659396,-0.03364138,-0.022504697,-0.062245566,-0.015492498,0.015363757,-0.09053454,-0.02371278,-0.079203054,0.01188832,0.07778518,0.19612363,-0.038306233 +6.5.1.8,"The enzyme is a GTP- and Mn2+-dependent 3'-5' nucleic acid ligase with the ability to join RNA with 3'-phosphate or 2',3'-cyclic-phosphate ends to RNA with 5'-hydroxy ends. It can also join DNA with 3'-phosphate ends to DNA with 5'-hydroxy ends, provided the DNA termini are unpaired [6]. The enzyme is found in members of all three kingdoms of life, and is essential in metazoa for the splicing of intron-containing tRNAs. The reaction follows a three-step mechanism with initial activation of the enzyme by GTP hydrolysis, forming a phosphoramide bond between the guanylate and a histidine residue. The guanylate group is transferred to the 3'-phosphate terminus of the substrate, forming the capped structure [DNA/RNA]-3'-(5'-diphosphoguanosine). When a suitable 5'-OH end is available, the enzyme catalyses an attack of the 5'-OH on the capped end to form a 3'-5' phosphodiester splice junction, releasing the guanylate. When acting on an RNA 2',3'-cyclic-phosphate, the enzyme catalyses an additional reaction, hydrolysing the cyclic phosphate to a 3'-phosphate [9]. The metazoan enzyme requires activating cofactors in order to achieve multiple turnover catalysis [8].",384,1.0,-0.07110591,-0.09608446,-0.099962436,-0.07326157,0.027438134,-0.055594128,-0.012923946,0.013782674,-0.016723407,0.031796597,0.12612534,0.015486073,-0.08854256,0.056975454,-0.03532133,0.08063546,-0.14985697,-0.05810697,-0.00055141083,0.0013105087,0.100909196,0.026581958,-0.01127906,0.0032696826,0.0055871266,0.031718,0.057258077,-0.03411087,0.019470878,-0.030020088,-0.015380555,0.0023925889,0.063589856,-0.0022246945,0.009721011,0.13336994,-0.018525518,0.034899935,0.007861962,0.059072636,0.0494594,-0.007927409,0.012035177,-0.037392493,-0.031717706,-0.027939593,0.0049069473,-0.0025723046,0.022429788,0.07254292,-0.07949749,-0.03604741,-0.027068043,0.008408891,-0.012447369,0.064613886,-0.08703993,-0.004123133,-0.024999311,0.043769248,0.042417586,-0.018696016,-0.06996559,-0.037791833,0.12927753,-0.060850356,0.062078483,-0.026298817,-0.011148119,0.0008505528,0.017038513,-0.023033211,-0.03092214,0.0107472185,-0.088900074,0.10827419,0.0081767775,0.0025399532,0.012673782,0.02389019,-0.013086558,0.024156805,0.07602807,0.068832695,0.020676905,0.019625833,0.018410856,0.11334082,0.010143402,0.049460113,-0.0072192415,0.0039042446,0.030392231,-0.0042343303,-0.022500364,0.10716885,-0.024090927,-0.033405747,0.02518485,-0.022727259,0.04481722,0.010501416,-0.031165002,-0.0715381,-0.01334251,0.020824322,-0.031240204,0.08411036,-0.0056185215,0.06463964,-0.031877052,0.046840906,0.07460469,-0.069128156,-0.023091676,0.08604306,-0.008732343,-0.026946496,0.054492492,0.054939304,0.030976469,0.031264294,-0.045604803,0.050187375,-0.050893046,0.029918345,-0.117000654,1.846137e-33,0.054493904,0.0302364,0.025547426,0.03303996,0.0008652799,0.019869804,-0.10873533,-0.058537204,-0.11995281,0.026464248,-0.067449115,-0.063337125,0.025311075,-0.02807814,-0.07481338,-0.020638635,-0.051583048,0.027536733,0.0100513315,0.028892657,0.029517839,0.00066832814,-0.038822517,-0.026348108,0.018407622,0.022643005,-0.021728668,-0.024892136,0.0671091,-0.02735127,0.03623248,-0.09598389,-0.0890411,0.0067019784,0.091528274,-0.050455518,-0.0035728815,-0.024864607,-0.035133794,0.12331803,0.013813568,-0.018355642,-0.051939707,0.028505042,0.037468143,-0.051486704,-0.0154949445,0.02704024,0.03514444,0.010977149,0.078566566,-0.06244433,0.021098185,0.031461332,-0.07690737,0.017087532,-0.019154511,-0.020217896,0.016199352,0.04273088,-0.0006278679,-0.002894548,-0.011176101,0.092912935,-0.0029272335,0.0061516813,-0.08261145,-0.07992754,0.050529685,0.040581264,-0.10081298,-0.036932513,0.05028805,0.02101518,-0.020064179,-0.06368527,-0.054149427,-0.04637071,-0.016748378,0.05194995,-0.04043126,-0.044918858,-0.038109746,0.030426553,-0.099781424,-0.012369229,-0.029095192,-0.09970201,-0.04526484,-0.0129020065,0.04576794,-0.063205205,0.014654579,-0.009335487,0.05032619,-3.452599e-33,0.11655041,-0.09011298,0.06670813,-0.09276963,-0.08976596,0.038293626,0.04676919,-0.063772514,-0.04093764,-0.07233472,0.037272964,0.058344815,0.040114272,0.0059145596,-0.024397682,-0.0039974493,0.08821682,0.04294303,0.04004313,-0.049232043,0.0716915,0.031310007,-0.031309985,0.047481347,0.014923983,0.015905622,0.0022843538,0.04444734,0.011853318,0.08057036,-0.06349134,-0.019288452,-0.0504572,-0.03036448,0.0034585025,0.03705787,-0.07730556,-0.011602413,0.07078217,-0.06011574,-0.0381334,0.027159464,0.04462,0.044230122,-0.03479259,0.07590896,-0.016263548,-0.0013531611,-0.054746855,-0.06523088,0.020218093,0.020068483,-0.042287342,0.018185766,0.05549697,-0.05621235,-0.02905944,-0.035334285,-0.027201911,0.03172267,0.017213373,-0.052310564,-0.011385512,-0.046114508,0.051109955,0.054021604,-0.0022210863,0.04428949,0.032550946,-0.039854836,-0.018130237,0.012268888,0.044090807,0.045939837,0.007037558,0.0065071774,-0.0792009,-0.04501626,0.05257206,-0.05284422,-0.027413733,-0.02206392,-0.018185088,-0.047380365,0.07045938,-0.08780227,0.06723238,0.13925004,0.060398687,0.030423107,0.0021319594,-0.0062213703,0.024005365,0.029749824,0.023642914,-5.4191375e-08,-0.013647402,-0.06336079,-0.017168893,-0.07117178,0.02655923,0.11836332,-0.0069521945,0.0066644684,0.12415047,-0.0491013,0.0035815705,0.024385637,-0.05694138,0.0589387,0.072158,0.010540321,-0.03413128,0.030523567,-0.012509515,-0.034479994,-0.12115925,-0.0028079837,-0.15156022,0.013020793,-0.022936916,-0.0057439636,0.049600128,0.119384885,0.036187105,0.008217264,0.00520549,0.012727515,0.037275657,-0.0066258684,-0.089177035,0.07885733,-0.029348234,0.026104348,-0.052975863,-0.00029217105,0.05751853,-0.0076098074,-0.074026965,-0.038463198,-0.06152432,-0.017045895,0.00035816606,0.042368148,-0.027955279,0.03263171,0.091699556,-0.0019339907,-0.010532869,-0.016840788,-0.04576923,-0.042183593,-0.007141929,-0.025304893,-0.030027373,0.012180316,-0.05469467,0.021746758,0.0890913,-0.04569965 +1.1.1.408,"The enzyme, characterized from bacteria, is involved in a pathway for D-threonate 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+1.1.1.410,"The enzyme, characterized from bacteria, is involved in D-erythronate catabolism.",384,1.0,-0.014313596,-0.0473485,-0.073431574,-0.0071761957,-0.045646522,0.014961172,-0.02376823,0.05963509,0.01398901,0.016801314,-0.023892434,-0.016667692,-0.046814464,0.07219558,-0.0057678698,0.014789312,-0.042255312,0.063451275,-0.047959927,0.0046167085,0.043355577,0.05349949,0.03178263,-0.03198653,0.069574334,-0.0046572112,0.087719865,-0.027787019,-0.045996793,-0.041770507,0.0007444544,-0.08005697,0.103584856,0.00553737,0.07082812,0.04120019,-0.036578797,-0.024220372,0.03564239,-0.024126375,0.029961571,0.014969226,0.015247259,0.0019474408,-0.067663886,0.01127856,-0.02905368,0.008074235,-0.0033292903,-0.02182968,-0.026297078,-0.06300677,-0.04515836,0.00076920737,-0.014407633,-0.016142642,0.04381021,-0.02228497,-0.06356027,-0.028137278,0.07182713,0.025919605,0.0660702,0.032336105,0.03930302,-0.040366456,0.040305905,-0.06287989,0.025944144,-0.040687215,-0.06396342,-0.11199199,-0.075895414,0.07340272,0.007478747,-0.037995897,0.051835254,0.0016463725,0.021660328,-0.036909215,0.054046348,0.059243824,0.037913576,0.10923278,-0.013396741,0.10004766,0.006104398,0.004418496,0.03262148,-0.014375833,0.01324484,-0.08319898,-0.061063994,-0.042976815,-0.09889233,-0.018977769,-0.002997718,0.055717103,0.053628698,-0.038726654,-0.021676414,0.07191378,-0.04614201,-0.049860787,-0.06595637,-0.061245266,0.00068195036,0.04801476,0.010245696,-0.076471955,0.07212114,0.008382666,0.048471674,0.06363013,-6.132225e-05,0.07294079,0.07911597,-0.0603106,-0.053781543,0.014637923,-0.0026216318,-0.050432097,0.07280003,0.07475529,-0.04815438,-0.0076914574,-0.09036359,-2.711647e-33,0.060205556,-0.038483273,-0.011027939,-0.023989838,0.030670572,-0.008873428,-0.0676123,0.0056538465,-0.046017032,-0.013360212,-0.10928088,-0.07052312,0.08198435,0.03846213,-0.032051377,0.039912507,-0.030498795,0.0069431565,0.04211928,-0.004842882,0.04699968,0.053959277,0.007769225,0.029415952,-0.0043779085,0.05330763,-0.024979008,0.080090694,0.07038182,-0.027928803,0.0010145182,-0.14903057,-0.059305206,0.05968763,-0.014379759,-0.0014901116,-0.040185522,0.062132902,0.009382012,0.017338691,-0.006203625,0.05696782,-0.034517854,-0.0069675837,0.07624716,-0.029969212,-0.006714709,0.11113386,0.046369612,0.062089454,0.052821103,-0.04617804,0.14829755,-0.08800428,-0.07332529,0.033622812,-0.013493672,0.0062930076,0.052752275,0.085066676,0.0054354835,0.071031846,-0.01272845,0.055347227,0.080545045,0.039046567,0.004526847,-0.06613481,0.021053003,0.07245403,-0.08059796,-0.05376346,0.06335026,0.0034650841,0.019303285,-0.066782385,-0.052526094,-0.004954062,0.02368832,-0.005755821,-0.0075126686,-0.010261422,-0.030240271,-0.0076615447,-0.05349529,0.016134318,-0.05790277,-0.0720496,-0.093820296,0.07456073,0.033822566,-0.020741679,-0.12630081,0.012540786,0.067558244,4.2069763e-34,0.099849716,-0.055172555,-0.05113687,-0.045606703,-0.021526473,0.08050762,0.01235961,0.06130207,-0.0060706087,0.026594602,0.08445909,0.008332357,-0.029637944,0.0108594885,-0.020342577,0.04204454,-0.050751846,0.038366694,-0.012746182,0.009727201,-0.037501793,0.084951214,-0.035156686,-0.018309144,0.03553361,0.03536911,-0.026637753,0.05012463,0.010227206,-0.057900622,0.06503524,0.0037374755,-0.019015715,-0.056669757,-0.0834663,0.09167988,-0.060461756,-0.018728135,-0.00031738274,-0.04973732,-0.012867162,0.059559934,0.0027267735,0.05038374,0.0459881,0.05381663,-0.105652414,0.030229963,-0.029512903,-0.035490636,-0.0049815583,-0.0045063384,0.06322606,0.008342505,0.0032452513,0.06509406,0.05303826,0.03402522,-0.10708576,0.023449538,-0.034920644,-0.05847315,0.081375435,-0.005050058,0.013724586,0.02568151,-0.025354456,0.0570852,0.0095067145,-0.036161292,0.099200256,0.010787295,-0.0682286,-0.012371927,-0.10930782,-0.05651645,-0.06624399,-0.009760261,0.031201938,0.0017087281,-0.032393496,0.010616705,-0.022954948,-0.0048027947,-0.02969385,-0.10454817,-0.039408892,0.10273168,0.010312411,0.0765154,0.0175634,-0.043723438,-0.039561205,0.027088538,0.080784,-2.474897e-08,0.0663794,-0.07420345,-0.0013822907,-0.027995313,0.022351557,-0.013637802,-0.01955015,0.05417702,-0.0053810673,-0.015949436,-0.043750618,0.05216893,-0.0447228,0.007194871,0.04740821,0.05422593,-0.004586061,-0.010904288,-0.044239033,0.021501824,-0.031948958,-0.023208128,-0.12116587,-0.0071952525,0.03588344,-0.056430597,0.012132049,0.021423426,-0.045000203,-0.030731456,0.008377109,-0.014821935,-0.011242298,-0.046656694,-0.07652275,-0.0067179496,-0.06049695,-0.09426989,0.012125866,0.009079047,0.029473824,0.010833899,-0.032186937,0.039912954,-0.03435227,0.05478866,-0.03208333,-0.032131214,0.003659839,-0.018029815,0.020110471,-0.010314433,-0.010060205,-0.07040235,-0.17315096,0.1156195,0.003652047,-0.06442355,-0.011428556,-0.012643759,0.089015424,0.036659915,0.17052169,-0.0414132 +1.1.1.411,"The enzyme, characterized from bacteria, is involved in L-threonate catabolism.",384,0.99999994,-0.0071992464,-0.115823805,-0.06733709,-0.011780296,-0.03263396,0.06525781,-0.0652759,0.08275108,-0.0063719507,0.005260275,0.024291493,-0.012966025,-0.0030736472,0.03704264,-0.060987048,0.022776352,-0.04964734,-0.014018181,-0.013048761,-0.01791351,0.08179342,0.08795833,-0.013908758,-0.028016476,0.06652633,0.004130901,0.017475322,-0.047242332,-0.03969484,-0.042414423,-0.031123072,-0.0033355625,0.052926417,-0.038785372,0.06494852,0.072037615,-0.11664837,-0.0682475,0.08292464,-0.02142788,0.022726636,-0.06320521,-0.01872811,-0.06339387,-0.06894584,0.0018172432,0.047999874,-0.0165104,-0.03435551,0.046325676,-0.05151635,-0.062811084,-0.015161967,0.04231747,-0.10722699,-0.03443917,0.0221193,0.0053848466,-0.06517255,-0.0038342148,-0.012180187,0.0369942,0.013104636,0.07297646,0.049788177,-0.05924856,0.056122504,-0.029160457,0.0035646313,-0.016121406,-0.047281228,-0.07520879,-0.011280879,0.07428328,0.044042666,-0.025892433,0.08308939,-0.011342812,0.015850732,0.004078768,0.058773555,0.05620639,-0.015421308,0.106422,-0.028490566,0.013542868,0.033940233,0.0025165414,0.06011202,-0.014552786,0.047193933,-0.02983219,-0.058051113,-0.0580245,-0.06871919,-0.0143332835,0.004105917,0.021073576,0.06566388,-0.05540583,-0.00900014,0.056354187,0.009401818,-0.047253836,-0.061848436,-0.017329328,-0.003627539,0.05732942,0.052711338,-0.06479719,0.06996073,0.014521506,0.057046823,0.030477827,0.032446593,0.066369236,0.093155205,-0.12431698,-0.0454123,-0.033198763,-0.015490877,-0.06805043,0.07076929,0.064221315,-0.06570794,0.019070575,-0.12372504,-3.8530262e-33,0.06729785,0.017391874,-0.012890889,-0.08880385,0.06356358,-0.0681456,-0.07438043,0.025347535,-0.06677249,0.011731341,-0.062363006,-0.050586414,0.025436478,-0.011673813,-0.014895896,-0.0111017,-0.03906237,0.05082884,-0.014010129,-0.012638967,-0.0147034135,0.053131938,0.009315811,0.05947892,-0.0034889556,0.06913144,0.055560492,0.042870395,-0.006216796,-0.0299305,0.030591777,-0.083405204,-0.05995715,0.0110661145,0.036861222,-0.020541087,-0.028343372,0.04723141,0.016418753,0.046293594,0.06135958,0.08805013,0.00693274,-0.028131496,0.080040395,-0.08679417,-0.03766154,0.10158325,0.0313655,0.04892603,0.10999181,-0.08277002,0.09125675,-0.067293756,-0.061965015,0.07848023,-0.03998532,0.020280018,0.008370344,0.05857384,0.033036616,0.053198192,-0.018601993,0.08903472,-0.0021185125,-0.0092046,-0.027908327,-0.061439503,0.05129854,0.09765454,-0.07995031,-0.030821685,0.057590056,0.003922261,0.07811032,-0.050778348,-0.06997368,0.021406367,0.028966023,0.006725613,0.0407008,-0.03784891,-0.015630746,-0.0008155877,-0.073360465,-0.020421812,0.016817722,-0.086022854,-0.053104896,0.04326206,0.0371444,0.0038185783,-0.059030816,-0.018695777,0.010955122,9.712642e-34,0.11556871,-0.09641135,0.03734886,-0.038697466,-0.044613343,0.060628828,-0.011932936,0.03811336,-0.031034602,-0.009776442,0.06496169,0.0042261933,0.033050604,-0.015895704,0.038941436,0.005352473,-0.012810466,-0.0066215703,-0.033803336,0.00580736,0.006539361,0.034164518,0.004679453,-0.037790097,0.036140252,0.005373835,-0.025139883,0.08909499,0.082326405,-0.0286682,0.028312307,-0.0033750725,0.026638003,-0.09463079,-0.07592724,0.079476446,-0.03183147,-0.0030123475,0.041491162,-0.02691627,0.0113757895,0.021239515,0.008981574,0.025445033,-0.02933794,0.009714777,-0.0813322,-0.058473393,-0.010939196,-0.06584203,0.028317744,-0.008813641,0.029487126,-0.0016168315,0.0060541877,0.093462795,-0.024566246,-0.02387308,-0.07968513,-0.051620293,-0.0314627,-0.05722178,0.049849086,-0.01861839,0.04392962,0.024180193,-0.03278808,0.0069430796,0.021285577,-0.033008922,0.09580276,0.03737356,-0.036438003,-0.023170535,-0.04746346,-0.046974927,-0.0985512,-0.04368956,-0.008881412,-0.058210693,-0.02130546,0.005303696,-0.011246368,-0.06948859,-0.0022318172,-0.09638618,-0.039281055,0.12367647,0.029103115,0.060152024,0.0011911615,-0.033294868,-0.009951403,-0.0033855455,0.077251,-2.5203539e-08,0.018131124,-0.0652401,-0.022185031,0.029650971,0.018563496,0.027832957,-0.017590396,-0.002957442,0.013980114,-0.002113665,-0.02426445,0.0741424,-0.036919877,-0.001036786,0.044377558,0.03705387,-0.037479993,-0.013023692,-0.04812832,0.014152082,-0.068950795,0.0077532176,-0.11358135,0.02581081,0.04075144,0.008757107,-0.014276324,0.044177204,-0.06260957,-0.030359231,-0.019506643,0.06115217,0.0075777466,-0.08316025,-0.094779484,0.023520816,-0.022316847,-0.092772715,-0.0024031047,0.021638304,0.05129909,0.06519013,-0.08477961,0.055814095,-0.041953206,0.015762346,0.019128613,0.008285921,0.0029659965,-0.033016153,0.013336622,0.023562478,-0.028296534,-0.037147533,-0.08689263,0.090838246,0.03564423,-0.029657472,-0.008894148,-0.026277145,0.113090776,0.06113334,0.22783613,-0.07614646 +1.2.1.99,"The enzyme, characterized from the bacterium Escherichia coli, is involved in a putrescine catabolic pathway. It has a broad substrate range, and can also catalyse the activities of EC 1.2.1.19, aminobutyraldehyde dehydrogenase, and EC 1.2.1.24, succinate-semialdehyde dehydrogenase (NAD+).",384,1.0,-0.024212638,-0.023016626,-0.07621748,-0.053665705,0.038531568,0.112212844,-0.119380526,0.03321498,0.041913185,-0.017134046,0.026776856,-0.03898979,-0.033133175,0.04214425,-0.002614101,-0.001404765,-0.056285024,-0.023652071,0.00368746,-0.07501719,0.03792856,0.04302721,-0.046553288,-0.0068912385,0.023299672,0.015151581,0.044553906,-0.0068591014,-0.062382594,-0.047723614,0.016489403,-0.08727395,0.015104823,-0.06416167,0.01733494,0.07439472,-0.050246675,-0.03602816,0.05582967,0.023234842,-0.0235538,-0.032521915,-0.033039734,-0.044339146,-0.013144565,-0.07262318,0.070644625,0.02496372,0.003149516,-0.04956925,-0.021064695,-0.010946537,-0.005641557,-0.021249618,0.057226665,-0.0011344831,-0.058525037,-0.022716878,-0.051687386,-0.060701896,0.03189195,-0.04584009,0.010668285,0.012758392,0.02403399,-0.05883236,0.07029823,-0.07091941,0.0127257295,-0.05895128,-0.1024051,-0.081143305,0.009167605,0.07775968,-0.013276719,0.0118916845,-0.04247766,0.0027880894,0.09080096,-0.041180924,0.033272766,-0.030888222,-0.062853776,0.07527503,0.03436671,0.044123005,0.087547824,0.01727739,0.021135088,0.04497504,0.0067560812,-0.06283555,-0.01755642,-0.029606903,-0.077167004,0.02369802,-0.007261016,0.08426633,0.044065773,-0.049104944,-0.0033602482,0.14771764,-0.016483398,-0.026875814,-0.0374959,-0.014142679,0.015374647,0.1567734,-0.015750559,-0.005827836,0.015362484,-0.05213333,0.026871916,0.00966096,0.013833664,0.1171071,0.09155462,-0.077041574,-0.044866048,-0.043324534,0.04031783,-0.00046747748,0.069437906,0.12753442,-0.02787797,0.054061655,-0.14253236,7.610615e-34,0.06454827,-0.011451258,0.01569966,-0.0026626978,0.05644201,0.013507107,-0.11402281,0.11909466,-0.037119158,-0.003337722,-0.0627189,-0.022021737,0.10165278,0.0035874166,0.008443333,-0.027006509,-0.05089022,-0.046435613,0.0091077285,0.014254958,-0.002628574,0.02013479,0.0043690745,0.0507721,0.046380848,-0.004200151,0.010962442,0.0069513298,-0.016534492,-0.00358986,0.008489677,-0.11519113,-0.12774117,-0.04217825,0.042835478,-0.08501739,-0.028458675,0.022266297,0.034298826,0.052629128,0.018850079,0.055770468,0.021318447,-0.036622576,0.041338682,-0.049341954,0.010865904,0.14732419,0.018032948,0.055319667,0.07145081,-0.06016915,0.12533176,-0.07681064,-0.05043691,0.06124225,-0.023451438,0.025275238,-0.0125572495,0.108213656,-0.0014580273,0.05255054,-0.05487767,0.034975566,0.020945245,-0.012903027,-0.07451564,-0.020639902,0.037204605,0.06082951,-0.062027287,0.037915695,0.09890206,-0.038439702,-0.0013898709,-0.037624665,-0.119116,0.030161416,0.031386305,0.03139059,-0.01773713,0.011965518,-0.019866178,-0.032215938,-0.02757826,0.035986084,-0.047947474,-0.054933954,-0.018513985,0.053169813,0.022626702,-0.06283515,-0.0432383,-0.028137505,0.07234153,-1.764801e-33,0.069846265,-0.091167845,0.0071890284,-0.10380602,-0.006457874,0.08241732,0.013160583,-0.004130861,0.03683895,-0.006596629,0.04191544,0.056027148,0.07670644,-0.048433933,0.047537584,-0.0261133,-0.09024674,0.023652202,-0.014561708,-0.020262128,-0.009444253,0.05986895,-0.0045538284,-0.029171431,0.0937037,0.043940898,-0.010221993,0.098953605,0.020287197,0.026744599,-0.02379466,-0.02096614,-0.01678374,-0.013709597,-0.034228116,0.05458057,-0.056130677,0.015754068,0.027107172,-0.009024182,-0.013497803,0.029752444,-0.0692034,0.06549587,0.02966611,0.08103345,-0.08039756,0.050447084,-0.005197482,-0.060383666,0.0064577106,-0.037279803,-0.017631203,0.027683519,0.019809246,0.03350268,-0.03318605,0.004563696,0.022514341,-0.012623463,0.007800981,-0.022670176,0.03226015,0.017037872,0.005270161,-0.060290437,-0.06852037,0.009433161,-0.0069151837,-0.0062796706,0.07941828,-0.03799469,-0.029253187,0.014510392,-0.010720318,-0.022678586,-0.083670184,-0.03391025,-0.00670122,0.015498497,-0.015884673,-0.010833829,-0.040509857,-0.04986099,0.05116768,-0.013683102,0.028691974,0.116512634,-0.012802044,0.063669465,-0.048427716,0.03514791,-0.038226373,0.08022394,-0.005862126,-3.934059e-08,0.032036223,-0.0650264,0.05097513,-0.02146978,0.03812007,0.051294938,0.028670894,0.0013093223,0.03524064,-0.010858043,-0.016666882,0.062680304,0.0144534465,0.037307233,0.02315954,0.009133263,-0.009598817,0.014420489,-0.039333805,-0.001744645,-0.06878044,-0.017367745,-0.13611981,0.034509,0.021705853,-0.07853681,0.012246887,0.028111424,0.010189686,-0.0540673,-0.017804733,-0.005489604,0.048607763,-0.04122411,-0.07326181,0.0047286614,-0.034346163,-0.006689423,-0.02597222,0.020626815,0.052912146,-0.08389028,-0.06196313,0.009364867,0.021374147,0.049651302,-0.0007082214,0.013823349,-0.07002908,0.0021757346,0.014287056,-0.00912675,0.026799597,-0.01788526,-0.10029462,0.030725513,-0.04888515,-0.112675615,0.0332192,0.008668883,0.022529334,0.049229883,0.20816056,-0.02120892 +1.2.7.12,"Contains a molybdopterin cofactor and numerous [4Fe-4S] clusters. In some organisms an additional subunit enables the incorporation of tungsten when molybdenum availability is low. The enzyme catalyses a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO2 as well as the oxidation of coenzyme M to CO2. The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.",384,1.0,-0.034079544,-0.04437799,-0.09870741,0.065391585,0.100825116,-0.016700892,-0.08244482,-0.0035664297,-0.006538913,-0.0713395,-0.010236921,-0.070047356,-0.07434808,-0.00035999826,-0.07617928,0.051960804,-0.041518595,-0.02429451,0.0069811023,0.009119392,0.03962918,0.041152604,-0.011010926,-0.05399857,-0.032402832,0.05664684,0.03717213,-0.07862554,0.005797608,-0.018419594,0.04164763,-0.010972302,0.050817724,-0.026548013,0.015744293,0.11716989,0.05846502,-0.009394083,0.04973295,-0.007949982,-0.0035300094,0.063649885,0.087390855,-0.014955105,0.009466761,0.002890317,0.016983064,-0.024883587,0.002198351,-0.03933438,0.00028442487,-0.060438104,-0.08403614,0.06739419,0.046204023,0.04031388,-0.0610238,0.013544064,0.08609905,-0.045352526,0.08106931,0.017686425,0.09699981,-0.0070274267,0.036973633,-0.048537906,0.03968439,-0.040683698,0.071610585,-0.044118598,-0.03142441,0.052280266,-0.033122607,-0.06508681,-0.04646663,0.04270347,-0.021931784,-0.037862938,0.103689894,0.019779095,-0.035146408,0.030345177,0.06940389,-0.014994665,0.06863294,-0.043245472,-0.037253886,-0.05547195,0.039197166,-0.031300128,-0.007149159,0.0003712678,0.010109328,0.0046042674,-0.13274826,-0.008610152,0.122487485,0.038637176,0.0009544981,0.011378504,-0.03505495,0.05707368,-0.031205932,-0.05604113,-0.095517,-0.06660657,0.015539975,0.15947083,0.028764145,0.094311625,0.019384975,0.047144044,0.07206617,-0.010014205,0.046691332,0.03725516,0.008887454,-0.07184995,-0.07042525,0.0012283919,0.011614677,0.0079882005,0.019748159,-0.008435352,-0.039303243,0.018234693,-0.04426836,5.4490503e-33,0.116815135,-0.0043879603,0.025853429,0.02475434,0.033209275,-0.08048166,-0.08463244,-0.035816588,-0.024284275,-0.035880767,-0.033719752,-0.022021057,0.0765259,-0.027554043,-0.027282232,-0.06552211,-0.013005231,-0.03877069,0.060796376,0.0067093517,-0.014354941,0.053062886,0.0068048188,0.006325003,0.020399876,0.001196603,0.02520915,-0.014429595,0.049436208,0.00822621,-0.0030895474,-0.080223426,-0.13593231,-0.025125075,0.035383582,0.0095817195,-0.10931288,-0.03917538,-0.033541504,-0.011362261,-0.031242512,0.001666565,-0.060498517,-0.061020903,0.11258381,-0.010272847,0.023572983,0.1312894,0.02998978,0.031718276,-0.0644922,-0.038749114,0.033730097,0.013520786,-0.07524765,-0.0058228155,0.04274814,-0.06778846,0.023347758,0.057080805,-0.012837984,0.015090753,-0.020828104,0.069522575,-0.024185192,0.007733271,-0.0011290187,-0.008109958,0.021367624,0.07921505,-0.035458557,-0.014906707,0.008622195,0.0457766,-0.05964337,-0.09954524,0.03936095,-0.099442475,0.037641037,0.0049568554,0.041148506,-0.0041473233,0.050014287,-0.077750444,-0.009261202,-0.011589177,-0.10719582,-0.099187605,-0.014518434,0.059383895,0.036716245,-0.0067632464,-0.0093311155,0.009375011,-0.021452352,-5.5199896e-33,0.08264142,-0.07607798,0.035799783,-0.10725364,-0.098162994,0.0617452,-0.0061177383,-0.039846584,0.029772162,-0.06400265,0.05484005,-0.009235777,0.04851019,-0.02470753,0.03750187,-0.0011765914,0.033126373,0.0953879,0.082000785,-0.012830498,0.08374768,0.01901207,-0.061961636,-0.0754858,0.050497375,0.04501568,-0.030173598,0.026884433,0.05580441,0.039170366,0.020964887,-0.038337983,-0.043066684,-0.05417901,-0.08054321,0.0063369554,-0.09726741,0.016816078,0.038538415,-0.037611812,0.024076674,0.0024527437,-0.0013525818,0.0968807,0.054439962,-0.007030067,-0.09098894,0.044662077,0.06569801,-0.018746173,0.00084777275,-0.056355104,-0.085182674,-0.03957211,-0.010353085,0.06936502,0.017271139,0.011983346,0.006668446,-0.022383533,-0.016384313,-0.080895856,0.09078173,-0.0048493156,0.025171507,0.044175085,-0.010373136,0.07207922,0.04762563,-0.0166813,0.008337543,0.04099826,0.010123547,0.017513897,0.03226507,-0.057696138,-0.05068429,0.0020366095,-0.008907855,-0.008130252,-0.02472205,0.056142867,0.091073066,-0.116488256,0.011692496,-0.109214686,0.015066667,0.07762121,-0.023005798,0.04479875,-0.0616549,-0.050231528,0.005712326,-0.0038301107,0.040113945,-3.9247404e-08,-0.036426377,-0.032952018,0.060793117,-0.048113298,-0.044950128,0.0866582,0.07508284,-0.024902815,-0.012154141,-0.039976753,0.05014115,0.054859664,0.02166452,-0.05666725,0.016426673,0.073637865,-0.057420123,-0.053775188,-0.052540656,-0.015920382,0.0032419343,-0.07198908,-0.04947126,0.09305465,-0.0064928425,-0.022206329,0.03331129,0.095733866,-0.05709523,-0.056194965,-0.02559758,0.01601382,0.044658534,0.007402216,-0.04848955,-0.007649855,-0.038960744,0.010028925,-0.046044625,-0.031071045,-0.024222702,0.042578626,-0.04531139,0.048890244,0.03729676,0.030802596,-0.03054966,0.07634722,-0.020573638,0.04174113,0.040668763,-0.07010824,0.040392213,-0.03991626,-0.09626152,0.032529533,-0.010886517,-0.013118582,-0.04305286,-0.0073958384,0.054269657,-0.04721979,0.100277156,-0.022690024 +1.7.1.16,"Contains FMN. The enzyme, characterized from Pseudomonas species, catalyses two successive reductions of nitrobenzene, via a nitrosobenzene intermediate. It is also active on 1-chloro-4-nitrobenzene. ",384,1.0,-0.024635933,0.005711274,-0.05416095,0.011569409,0.07689052,0.046223175,-0.021508494,0.041816603,0.012848228,-0.08212275,0.012562771,-0.064142816,-0.08339907,0.10131823,-0.09059326,0.024490735,-0.048846006,0.006841924,0.0022094247,0.035242252,0.008144442,0.034083042,-0.011423055,-0.017003082,-0.05715041,0.0059681553,0.04826449,-0.032841586,0.059423823,-0.027385442,0.035636727,0.006090982,0.07400809,-0.018225087,0.079509325,-0.011688866,0.03904815,-0.03431334,0.059678763,0.0008870888,0.0020172677,-0.015429004,-0.03145258,-0.10690706,0.0295041,0.029697388,0.030676283,-0.0140349865,0.03802446,-0.07109929,-0.07451072,-0.042904362,-0.025068924,0.11487323,0.059225596,0.033293832,-0.013328167,-0.067464866,-0.053940516,0.08176456,0.038101364,0.04229702,-0.07014557,-0.011223566,0.07951556,0.058841165,0.02449855,-0.025314769,0.017687354,0.014486624,0.024937464,-0.012457132,0.021883074,-0.029029656,0.020160083,0.001972475,0.052174103,0.00851766,0.028411109,-0.09103078,-0.00876403,-0.004103405,0.073531464,0.04704918,0.022346348,-0.05444693,-0.07276022,0.006970714,0.07329179,0.06988256,-0.057092123,0.023279188,0.0067893276,-0.112863146,-0.037489764,0.09633593,-0.015974604,0.09185723,0.079136334,0.038483426,0.052359365,0.03589332,-0.050101135,-0.10357353,-0.060326792,0.07666631,0.061951462,0.07021286,0.09360244,-0.01855326,-0.037879534,0.035971448,0.011880045,-0.03520116,-0.06479238,-0.012824319,0.073251925,-0.044010773,-0.04433661,0.07741079,-0.0069447123,-0.025445433,0.011657959,0.07138084,-0.0047873296,0.060705394,-0.1284081,3.2803834e-33,0.018230394,0.042381894,0.012538006,-0.08029982,0.021185609,-0.037724312,-0.050084066,-0.020544253,-0.045998625,-0.030279167,-0.06754163,-0.028934987,-0.045572758,-0.049432814,-0.028515484,-0.028596744,-0.03653056,0.024630401,0.026034467,0.016495071,0.053226948,0.016274946,-0.05141311,-0.0140406275,0.03837453,0.033432182,0.0026114658,-0.017251793,-0.007710806,-0.028868407,-0.029801715,-0.053915974,-0.05660047,0.020193089,0.077226855,0.0013072656,-0.018251365,-0.012911757,-0.05180143,0.07763953,0.019593118,0.014880795,-0.09399077,-0.011858183,0.08142818,-0.01773622,-0.1241984,0.10056499,0.056451228,0.08313037,0.024889365,-0.031510543,-0.012008024,-0.009445103,-0.015532803,-0.018745616,-0.020046467,0.02252455,0.07280462,-0.018193485,-0.004062898,-0.009711774,-0.07072307,0.0048366943,0.056199282,-0.018182017,-0.010526444,-0.0070122113,0.0660064,0.0073926128,-0.116851255,0.03169159,0.03227412,0.049275436,0.061639115,-0.113487266,-0.043273054,-0.077416144,0.03529502,0.02247458,0.007796738,-0.053838935,0.0012937124,-0.059477895,-0.09416176,-0.00065624644,-0.012499593,-0.042665012,-0.052262012,-0.054959994,0.060329378,-0.13192068,-0.055617485,0.0025504637,0.010427082,-3.552726e-33,0.00047518665,-0.045060508,-0.019740816,-0.03601723,-0.06546523,0.02767303,-0.06380375,-0.03649461,-0.027472932,0.003008771,0.072024114,-0.06386426,0.06961561,-0.001427325,-0.06842761,0.06357998,0.023977714,-0.0085555315,0.044059515,-0.0022372315,-0.05573983,0.057768196,-0.01532707,0.10304561,-0.012895358,0.08647673,-0.008934261,0.12145421,0.11774772,0.10412035,-0.018553132,0.041053046,-0.030257149,-0.06644765,0.061313912,0.041984823,-0.010352347,-0.0009782276,0.016681151,0.008008605,0.056045916,0.009914107,0.01952206,0.07575185,-0.08428973,0.1439788,-0.09246768,-0.010767687,0.010862899,-0.08166936,0.027860155,0.020982647,-0.068502694,0.02353188,-0.027041612,-0.0067437585,0.021785188,0.01685603,-0.03410976,-0.016849771,-0.060337137,-0.047121022,0.033720512,-0.044248894,0.041156385,0.020357296,0.025425721,0.12556894,0.016415577,-0.014118049,0.012513818,0.039344337,0.081973,0.032950867,-0.07204519,0.0550697,0.04568932,-0.037584383,-0.014840904,-0.026268918,0.061845943,-0.016787784,-0.03927756,-0.10946329,-0.06313589,0.00031801482,0.01558868,0.09755082,-0.009060917,-0.022854349,0.057867397,0.08309771,-0.013254669,-0.027599577,-0.020323638,-3.4338996e-08,0.055532627,-0.089695394,0.016953694,-0.008005302,0.032532886,0.04211733,0.017864829,0.01359096,-0.039745186,-0.003906415,-0.019274225,0.042618293,-0.031033901,-0.04054137,0.048124813,-0.030085748,-0.055796392,0.028674133,-0.03959841,-0.025489487,-0.05861462,0.060937338,-0.111298434,-0.040893644,-0.024141474,-0.048358224,0.05964633,0.0052563106,0.05676129,-0.021436404,-0.013302927,0.06394726,-0.00042625706,-0.010574479,-0.09600483,0.0046652975,0.013143756,-0.017569654,-0.09782452,-0.030354038,0.009658242,-0.0012902683,-0.08627738,-0.02193885,-0.03532969,-0.014695003,0.025858669,0.012300194,0.020169105,-0.0009160246,0.03517582,-0.026994137,-0.00014105726,0.0110884905,-0.16067125,0.033740226,-0.0027655393,0.010032075,-0.03612968,-0.059054304,-0.040393356,-0.0011620154,0.108329326,0.057094872 +1.14.13.235,"The enzyme, characterized from Pseudomonas putida strains, catalyses the first step in a pathway for degradation of the plant hormone indole-3-acetate. When acting on indole, the enzyme forms indoxyl, which reacts spontaneously with oxygen to form the blue dye indigo.",384,1.0,-0.020904697,-0.06190854,-0.048146468,0.0048079663,0.062234145,0.116301686,0.0071782437,-0.0032711164,0.042468537,0.027274942,0.065087244,0.0074002747,-0.068957776,0.013781211,-0.040203243,0.15100032,-0.099676974,0.005991255,-0.055789154,-0.03523904,0.074595615,0.028356213,-0.031355463,0.024528844,0.023310238,0.011976748,0.022461168,-0.05293575,-0.026339684,-0.026891135,-0.034815393,-0.019456247,0.080703855,-0.035230655,0.015474461,0.001205351,-0.0037999765,-0.07307522,0.07407579,-0.036470093,-0.02247438,-0.017574577,-0.102235466,-0.062170777,-0.024843879,0.037200015,0.06975002,0.021876108,0.036143124,-0.095957994,-0.018248647,-0.05435428,0.0034578042,-0.017201783,-0.0032158378,0.03039539,0.063131884,0.045920532,-0.032338545,0.03740863,0.011205161,0.0052776365,-0.049216658,0.03839895,0.029796096,-0.028160982,-0.014983237,0.023759965,0.018388717,0.0011140001,-0.035848178,-0.079523005,-0.010395033,0.032827973,0.0241414,0.04186687,-0.0127762295,0.017441079,-0.019347694,-0.08522172,0.029802421,0.004691901,0.010364858,0.1368353,0.0009841863,0.015006779,0.03400028,0.028862556,0.032561697,-0.0151197,-0.017345788,-0.009512558,-0.050948568,-0.055007476,-0.0067850053,0.09626978,0.045001626,-0.042952966,0.07628038,-0.020537842,0.026123881,0.04851752,-0.052267168,-0.132232,-0.10756247,0.00061709696,0.0030764649,0.02748434,0.062878795,0.037572272,0.0029587212,-0.058292724,0.03008299,0.0154365515,-0.054165535,0.06438884,0.035960708,0.0073804357,-0.080598496,0.011767904,0.01381821,-0.041425075,-0.0034001756,0.10313677,-0.06430245,0.04544935,-0.08985988,-1.2475107e-34,0.118910976,0.048704147,-0.027828742,-0.027487736,0.03296202,-0.0077539147,-0.03977133,0.01106113,-0.019981973,-0.053705953,-0.0056081214,-0.105944656,0.008251322,-0.06674943,0.0031194307,-0.0048860484,-0.09539208,0.010195446,0.029413508,0.054442056,-0.011343139,0.037308935,-0.0956887,-0.00517039,-0.016286207,0.0181896,0.056552958,0.02255486,-0.010137915,-0.03273089,0.07878669,-0.033957865,-0.12608817,0.0040584677,-0.017968778,-0.056167703,-0.00054924295,-0.013825047,-0.03659726,0.07771569,0.04961202,0.09777706,0.030763006,0.039202068,0.060909197,-0.015665734,-0.019972567,0.14406821,0.07913095,0.118862785,-0.050254785,-0.04766854,0.12075426,0.018504275,-0.011805851,0.042204678,-0.03282709,-0.039483916,0.030125419,-0.008492813,-0.0021007769,-0.0057609202,-0.020391492,0.018399315,-0.041994065,-0.0076973285,-0.08619357,-0.03973533,0.040991485,0.06237789,-0.08839917,-0.00372853,-0.030891333,0.01344749,-0.043031707,-0.058792353,-0.020840714,0.0064960597,0.016235266,-0.0070817037,-0.037535924,-0.037279677,0.015245114,-0.014080109,-0.009145355,-0.034152724,-0.03524457,0.014040545,-0.08575723,0.010465904,0.10856747,-0.09221913,-0.06789252,0.054254673,-0.011102905,-7.0757574e-34,0.040063355,-0.08203485,0.0021481523,-0.058043867,-0.020161437,-0.014565434,-0.051421303,0.061293688,0.044658415,0.03142688,0.04132291,0.04947722,0.08442229,0.057641912,0.020497615,-0.044228807,0.031224217,0.08393703,-0.019354908,0.02805407,-0.05120308,0.06977353,-0.03195779,0.018140126,0.029818684,0.07012376,-0.01347329,0.09537574,0.002847696,0.06635399,0.08694593,-0.016419988,-0.073071666,0.041344054,0.07125787,0.04772273,-0.019897366,-0.021865748,0.028262064,0.063991845,-0.012762731,0.042529386,0.003141822,-0.011387581,0.021649262,0.024906447,-0.12271989,0.10988077,0.013217957,-0.07755213,0.008161404,-0.06657658,0.009149375,-0.007808645,0.0051869266,-0.04543379,0.0042503653,0.0061009317,-0.10148442,-0.009133043,-0.044383336,-0.049761415,0.051427536,0.06761264,-0.06868267,0.02888413,0.017125607,0.065423965,-0.0077459114,-0.045266397,0.027153896,-0.009107125,-0.0052601993,0.08117401,-0.043234233,-0.08134643,-0.05348543,-0.014593846,-0.03078018,0.010389401,0.027223099,0.026706612,-0.032191124,-0.10224664,0.007346406,0.0026677006,-0.03544818,0.14678237,0.0072646295,-0.023869446,0.008720249,0.033740412,-0.023089783,0.066311,0.0652573,-2.9838123e-08,0.013021274,-0.07101818,0.119905196,0.0037766802,-0.0018787599,-0.008461016,0.04058157,0.022324758,0.04767643,-0.07764928,-0.08071007,0.05690046,-0.032897864,0.009916397,0.04035434,-0.044435576,-0.009115958,0.051592793,-0.053916488,-0.026595743,-0.08746621,-0.040039506,-0.08093169,0.03365696,0.014844802,-0.043710228,0.08219668,-0.007762743,0.051307384,-0.030925546,0.038669948,0.052323245,0.026706878,0.016176136,-0.1298581,0.030599419,0.010046424,0.01579569,-0.022996303,-0.0008634449,-0.01935618,-0.026090408,-0.09501689,-0.06512664,0.05870329,-0.02756853,0.015823105,0.012680456,-0.009457026,-0.04170239,0.0171881,-0.020842131,0.0053390837,-0.02177295,-0.08978251,-0.07544614,-0.021867665,0.049886316,0.017900947,0.0067473757,-0.030756086,0.015604634,0.16170178,0.01235733 +1.14.13.236,"This bacterial enzyme belongs to a family of soluble diiron hydroxylases that includes toluene-, benzene-, xylene- and methane monooxygenases, phenol hydroxylases, and alkene epoxidases. The enzyme comprises a four-component complex that includes a hydroxylase, NADH-ferredoxin oxidoreductase, a Rieske-type [2Fe-2S] ferredoxin, and an effector protein.",384,0.99999994,-0.06765664,-0.029827287,-0.052759584,-0.0066783987,0.098647945,0.00097633037,-0.07796457,0.048735376,0.011806094,-0.075642645,-0.026821535,-0.07770526,-0.0013509335,0.0936537,-0.071738645,0.025605492,-0.13730992,-0.026723955,0.010332681,0.005088084,0.023247305,0.06738802,-0.0011443035,-0.008138633,-0.019328691,0.05521468,0.121704675,0.032253075,-0.03989797,-0.062804654,0.06213669,-0.014399188,0.034238376,0.004115432,0.0336731,0.08566428,0.045941923,-0.0366234,0.0696526,0.015562492,-0.0037167494,0.035708144,0.04177859,-0.046196856,-0.0043673324,-0.058806874,0.019446567,0.030327741,0.06129551,-0.028556243,-0.08704344,-0.035077214,0.006681486,0.10831008,0.09750486,-0.016086068,-0.008255865,-0.061047256,-0.058000464,-0.02692233,0.07985066,-0.034148544,0.006161024,0.027579365,-0.075352736,-0.016811674,0.014357849,-0.06486156,-0.025585836,-0.079466105,-0.095091075,-0.019026605,0.018496936,0.07363223,-0.03123444,0.04451448,-0.011056328,0.002133095,0.03760121,-0.029970722,0.017534303,-0.006620051,0.024645062,0.108884856,0.03656073,-0.0682134,-0.04076896,-0.0026676813,0.03717406,0.025847996,-0.029354597,-0.016225848,0.0074403747,-0.036004044,-0.07874497,-0.016262658,0.07252052,0.009622979,0.0017974948,0.013167475,-0.06800949,0.016045962,-0.0025434454,-0.13884604,-0.07059288,0.014411252,0.026218811,0.14302287,0.052569136,-0.019947581,-0.012672632,0.020083036,0.03281977,-0.006772926,-0.006786364,0.047813505,0.031108648,-0.047646046,-0.048910316,0.012456304,0.03408553,-0.042558245,0.044056993,0.03234747,-0.061174028,-0.010756535,-0.13975967,2.6378694e-33,0.030006984,0.063743286,-0.04656099,-0.0024881766,0.046166006,-0.007047905,-0.06688352,0.06268829,-0.038633622,-0.049408782,-0.055759817,0.0054892213,2.0829619e-05,-0.0004592239,-0.012582721,-0.08771749,-0.058694687,0.029178176,0.014711344,0.012226562,0.0056088176,0.040221527,-0.054486185,0.016033947,0.050228998,0.06679929,0.022236416,-0.0010876085,0.041556876,-0.005651514,0.045079704,-0.07365024,-0.0910838,-0.054526597,0.018860506,-0.015317717,-0.029090537,-0.010107858,-0.026314897,0.03298289,-0.026110744,-0.0031485949,0.0022859236,-0.09808866,0.052599937,-0.09310533,-0.060423926,0.124280624,0.053929493,0.10824747,0.053072702,-0.04452794,0.04124418,-0.060819812,-0.06214797,0.047507927,-0.016355906,0.033519,0.053679988,0.053413138,0.012689888,0.033813406,-0.07357908,0.024131253,-0.018746762,0.010704317,0.004087404,-0.038517904,0.018170938,0.15571573,-0.053383444,0.044451494,0.06909479,-0.019829703,0.034098066,-0.07685134,-0.06891204,0.010748964,0.07813661,0.02996405,-0.02617066,-0.040128626,0.020267505,-0.019577635,-0.045000076,-0.0034650124,-0.018145183,0.0144919455,-0.080295295,0.053266242,0.02153903,-0.068924695,-0.03749561,-0.035723846,0.017158827,-4.031733e-33,0.063494354,-0.09176407,0.0381577,-0.12252896,-0.030028572,0.11754022,0.024539132,0.01607254,-0.008892796,-0.018814137,0.0958809,-0.009875238,0.029140338,-0.04737916,0.010302043,0.044878,-0.01106956,0.0104248375,0.03368933,-0.01657868,0.04414062,0.04351362,0.039414484,-0.008507298,0.011831885,0.0070047635,0.0037013197,0.0996222,0.03373127,0.08027675,-0.03940114,-0.033130806,-0.0052225217,-0.05686787,-0.028207274,0.054937754,-0.115740225,-0.050863225,-0.010129783,-0.024616104,0.026606113,-0.041165818,-0.06638786,0.12810555,-0.00045161825,0.08694589,-0.076081425,-0.011554821,0.05229656,-0.019729212,-0.0036526665,-0.011477152,-0.028961727,0.0001918327,-0.020682747,0.0066119703,0.022157736,0.0118474625,-0.023276297,0.0017780353,-0.056023758,-0.05389087,0.028670674,0.063008614,0.046191372,-0.0074573047,-0.080852784,0.010711819,0.04630189,0.00052569766,0.0998695,-0.068804555,0.04241282,0.07294026,-0.013639522,-0.0052887984,-0.044632476,-0.029432975,-0.02221342,0.023005,0.027087288,0.00041633667,-0.020671,-0.043159503,0.002563718,-0.05658454,0.039040864,0.05431126,0.009269704,0.048679657,0.006690979,0.11001589,-0.02829756,-0.01855003,0.067922145,-4.17756e-08,-0.0007392177,-0.1466308,0.07501597,-0.019060353,0.015789313,0.021068035,-0.0008573017,0.020316062,-0.007731776,-0.04327439,0.065331355,0.095066965,-0.020648696,0.011547572,0.04861613,-0.0032844702,-0.012245228,0.01609375,-0.013908385,0.017215684,-0.048186485,-0.011850544,-0.061714772,0.018460087,0.017176325,-0.04808609,-0.041779947,-0.04085804,0.0027316913,0.002506231,-0.022997184,0.034788404,-0.044474244,-0.049214125,-0.10754673,0.014127189,-0.08150078,-0.044721764,-0.044195607,0.013264146,0.027808892,0.0038375384,-0.08642723,-0.011081796,0.034890447,0.052200973,-0.021208744,0.021632683,0.012766581,-0.023254147,0.037013326,-0.028725024,0.0039880546,-0.04652939,-0.1252887,0.07879984,-0.011952863,-0.029327057,0.015079105,-0.054052327,0.015301578,0.08581804,0.18534985,0.0023818517 +1.14.14.44,"This cytochrome P-450 (heme-thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucosides (R)-prunasin and (R)-amygdalin. It catalyses three different activities - isomerization of the (E) isomer to the (Z) isomer, dehydration, and C-hydroxylation.",384,1.0,-0.099688746,0.017887196,-0.08722673,0.023448939,0.058431093,0.03668579,0.0047051236,0.02413578,-0.0020625906,-0.02197357,0.010470145,-0.01024362,-0.06889011,0.009962675,-0.043212954,0.04248674,-0.11212125,0.023569103,-0.053002182,-0.025984524,0.015457036,0.012469099,-0.026594773,0.048238173,0.055495474,0.014109655,0.06573795,0.041529503,-0.034362055,0.009006981,-0.049733784,-0.07545104,0.053263627,-0.008485246,0.001895649,0.069760464,-0.1348819,-0.06642867,0.0026286768,-0.07162596,0.046618413,-0.04778822,-0.07386785,0.048210878,-0.038404915,-0.08630006,-0.01129042,0.017738862,-0.027136276,-0.06556472,-0.0091714235,-0.049518146,-0.061047845,0.038617197,-0.013059546,0.0055560977,-0.022047374,-0.0003606583,-0.020244522,-0.02549983,0.0075872727,0.028841585,-0.10429607,0.018701002,-0.030320594,-0.075330995,0.021247458,-0.046002172,-0.007767552,-0.09075507,-0.033147644,-0.10684189,-0.044112828,-0.034148417,-0.028187815,0.10134286,0.0105196,0.021311224,-0.05623899,0.008232294,0.098334834,0.0071650823,0.07503308,0.10475093,0.06341317,-0.003720823,-0.008570802,0.0298025,-0.009192036,0.025002023,0.055228103,0.013103557,-0.04014554,-0.023834633,-0.08429636,0.08345603,-0.014470491,-0.013627893,0.070582114,0.020230183,0.025957266,0.09697628,-0.0036553193,-0.1087022,-0.017747002,0.05543225,0.0234253,0.088278845,0.069888614,-0.08007878,-0.08241437,-0.024064315,0.0007744895,0.012673153,-0.021850912,0.086426586,-0.0065196087,-0.014687259,0.022847772,-0.009221727,-0.023889454,-0.010931667,0.043455668,0.012433874,-0.008397377,-0.0030621553,-0.11791127,8.243747e-34,0.10139661,-0.008130361,0.008300873,-0.040839396,0.038864132,0.015075876,-0.073884934,-0.013277571,0.01075524,-0.007569581,-0.1320476,-0.080734506,0.0005668324,0.013074569,-0.07134338,-0.029355615,-0.040360488,0.022598483,0.09272218,-0.0020894078,-0.019075945,0.041863143,-0.042456172,-0.0335604,0.009040426,0.12031335,-0.03523356,0.030876175,0.029619653,-0.009909463,-0.010597227,-0.044024196,-0.09050152,-0.026616605,0.060225107,0.019138059,-0.01934324,0.021662261,0.0103829615,0.08581086,0.017690986,-0.030521441,-0.01245426,-0.032277733,0.06047395,0.033062875,-0.09131586,0.06697234,0.019762201,0.0857983,0.08763433,-0.05390028,0.09155588,0.061668735,-0.10201097,-0.0121471435,0.032750443,-0.0025477714,0.06670391,0.015455107,0.025681233,0.09593365,0.00178784,0.004841287,0.046701733,0.06045204,-0.0764587,-0.044832025,-0.03679444,0.08338938,-0.06045256,-0.026768586,0.11622185,-0.0481287,0.06447705,-0.030420387,-0.02106783,0.053934142,0.060090363,-0.0019887378,-0.0695036,0.025466597,-0.0113152815,0.006079588,-0.0132102,-0.01552941,-0.04531108,-0.022905327,1.0498967e-05,0.0925443,0.03464297,-0.02488494,0.0010550158,0.011307782,-0.004377583,-1.7023313e-33,0.069460444,-0.09928124,-0.0031258343,-0.0907334,-0.019372879,0.032259494,-0.034476295,-0.030339587,-0.02166619,0.0008294212,0.08197834,-0.011414373,-0.008067208,0.04038848,-0.008796834,-0.01247586,-0.008180547,0.09190627,-0.049077295,0.042427514,-0.0076455576,0.046713755,0.026687609,0.022099614,0.05488404,-0.016323451,0.06907495,0.040956646,0.10686449,0.014130157,-0.05000307,0.030181544,-0.050141685,-0.068024054,-0.009232804,0.07771864,0.0016851893,0.032633323,0.010250125,0.009553273,0.006511471,0.038714748,-0.008068069,0.077093266,0.10196296,0.08156772,-0.045119993,-0.07135496,-0.08863268,-0.038687643,0.099985436,0.0401157,-0.0137012405,0.0048501696,0.05014475,0.030061344,0.012656669,-0.034001883,-0.013825177,-0.052797534,-0.056859124,-0.034715604,-0.00441648,0.022607813,0.04082515,0.045862053,0.014303821,0.08472735,-0.005720903,-0.0025481994,0.05745973,-0.021319596,0.023217041,0.07679769,-0.0063340496,-0.035211228,0.024888653,-0.051462833,0.0415657,-0.022495145,0.009827632,-0.017129883,-0.059708465,-0.08015848,-0.07679571,-0.07501038,-0.003459658,0.102111556,0.014422404,-0.040131886,-0.022041922,0.077078454,-0.0015597562,0.0861924,0.05124547,-3.8300275e-08,0.020914862,-0.11769185,0.024243182,0.00397591,0.028430913,-0.010187326,0.06609337,-0.001164078,0.0027718595,-0.026420468,0.004321296,0.09838847,-0.009332913,-0.031672645,-0.010374547,0.010662104,-0.004396307,0.027382161,0.030483862,0.012407036,-0.06844233,0.016832449,-0.10437306,0.007827297,0.06594666,-0.14498743,0.030063462,0.056957245,-0.022272803,-0.033111397,0.049616992,0.072033554,-0.02384159,0.042593896,0.010987703,-0.021948887,0.013304421,-0.043948606,-0.030184668,-0.033793278,-0.06870295,-0.07033157,-0.025253419,-0.024887795,-0.039368797,-0.022583755,0.03598261,0.03390545,0.06304962,-0.010507265,0.00063613016,0.03140601,-0.04502909,-0.0978906,-0.028317228,-0.01010779,0.080186024,0.003326429,-0.044837937,-0.081925765,0.024118686,0.009161585,0.15347598,-0.032271005 +1.14.14.45,"This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of glucosinolates in plants. The enzyme catalyses the N-hydroxylation of aromatic aldoximes derived from L-tryptophan, L-phenylalanine, and L-tyrosine, forming an aci-nitro intermediate that reacts non-enzymically with glutathione to produce an N-alkyl-thiohydroximate adduct, the committed precursor of glucosinolates. In the absence of glutathione, the enzyme is suicidal, probably due to interaction of the reactive aci-nitro compound with catalytic residues in the active site.",384,0.99999994,-0.079980485,0.0030623383,-0.07958232,-0.01408083,0.06087104,0.029824981,-0.081190124,0.08553137,0.018822253,-0.005882728,0.061885376,-0.009067309,-0.020991703,-0.007039301,-0.11289613,0.040572483,-0.009803579,-0.032273,-0.08155205,-0.11802191,0.037833825,0.053007007,-0.042230073,-0.03025099,0.0010154978,-0.05349822,-0.020460537,0.0023088942,-0.025866585,-0.008123453,-0.089191414,-0.036441658,-0.019152632,-0.02519798,0.003704472,0.07951393,-0.06797097,-0.027348043,0.057583455,-0.049490824,0.016519152,-0.07960685,-0.05609361,0.017355248,0.01590442,-0.06545661,-0.0029539021,0.029658068,0.02890744,0.0007472566,-0.04369827,-0.044617526,0.032602742,-0.010485217,0.00652857,-0.030290477,0.020054188,-0.004219645,-0.02295909,0.04082439,0.019562565,0.025752582,-0.08719736,-0.039862275,0.01255313,-0.031194495,-0.00014482284,-0.04311487,-0.029959979,-0.01487366,0.032513145,-0.07705758,-0.038647987,-0.011521918,-0.03323227,0.05593071,-0.058859244,-0.027303176,-0.0016794326,-0.0032490792,0.09594611,0.052554287,0.06325197,0.07470745,0.057971057,-0.004628069,-0.064030066,0.1172144,0.021076266,-0.022125322,-0.018485773,0.008759192,-0.067382805,0.03399754,-0.06275478,0.07107807,-0.037904806,-0.048509624,-0.055188347,-0.04720367,0.03171837,0.019209107,-0.0013784411,-0.06289674,-0.055414088,0.033090137,-0.0041238526,0.07546613,0.04736893,-0.022248473,-0.053830747,0.00016327178,-0.027743671,-0.032845292,-0.03141308,0.12479923,0.010571353,-0.041621804,-0.10965325,-0.039440304,0.023616422,0.012362807,-0.012948814,0.06315699,-0.02039363,0.013201963,-0.032528237,4.070742e-33,0.12011213,0.039034154,-0.007967813,0.026299294,0.07801815,-0.0011652384,-0.07423289,-0.01810304,0.011981562,-0.0028820883,-0.06159853,-0.121756986,-0.056131974,-0.00700053,-0.04198123,0.010595369,-0.02433558,0.00065841357,0.0654117,0.0011798618,-0.013281258,-0.02202949,-0.07713354,-0.014836907,-0.027266406,0.10860147,-0.006131523,0.023131346,-0.022521906,-0.016625574,-0.02104602,-0.092474304,-0.015968347,-0.040569786,0.016686704,-0.040820025,-0.003023536,0.026349764,-0.012033582,0.058741007,-0.039172214,0.06438602,0.02009871,-0.04001678,0.09229654,-0.0067068683,-0.108197995,0.06621701,0.0035918949,0.14273788,0.048558444,-0.06000506,0.08771222,0.08824436,-0.06898672,0.03760201,-0.019286575,-0.015116697,0.048172444,0.027763486,0.10573369,0.051469162,-0.018224608,0.036215484,-0.032960948,0.01906162,-0.059083454,-0.003945686,0.012385837,0.16252227,-0.05981951,-0.04042474,-0.0010454942,0.025993967,0.063002765,-0.09930671,0.008896579,0.08642909,0.01863959,0.03557914,0.08569273,0.023432204,0.008248408,0.0077144867,-0.06157036,0.038380172,-0.01652078,-0.0137872845,-0.019408606,0.00958073,0.043919936,-0.029299771,0.012512153,0.031958617,0.0077646575,-5.0949312e-33,0.11838061,-0.10331829,0.09241365,-0.1001774,-0.04908316,0.03396809,-0.045059536,-0.055073023,0.017467348,0.0076660407,0.100804694,0.001954679,-0.0021102913,0.0353521,0.020537699,-0.073227376,-0.054209966,0.07708102,0.002821167,0.027534774,-0.018560318,0.015527299,0.018049559,-0.045131296,0.06351621,0.00693151,-0.032670844,0.04162216,0.06541198,0.033489652,0.020885687,0.015274174,-0.105895296,-0.025851801,0.062931314,0.07471575,-0.018183898,0.050367586,0.015058669,0.040180486,0.019654466,0.027362052,0.06266583,0.04832701,0.025955876,0.052771073,-0.09080586,-0.091221906,-0.055465337,-0.12708598,0.069182515,0.041931573,-0.044022653,0.04502457,0.06758241,0.050359737,0.037125118,0.0032216746,-0.029168628,-0.07853312,-0.07942628,-0.02979594,-0.029128173,0.0043420326,0.013880945,0.05505189,0.017907979,0.055908248,0.061795376,0.08230365,0.0441389,0.016689042,0.030411925,0.044442795,-0.059592098,0.0034762048,-0.021788316,-0.010351645,-0.017606838,-0.03952888,0.0011127044,0.013231995,-0.039820347,-0.056583084,-0.043971658,-0.107065484,-0.020009542,0.14575204,0.07577514,0.0049391156,-0.03110608,0.057707954,-0.008974832,0.030362528,-0.018022165,-4.5939647e-08,-0.026160652,-0.06292108,-0.022858582,-0.019527053,0.0028619866,0.0059232977,0.02165015,-0.02246447,0.065150075,0.006567134,-0.024014723,0.08875061,-0.050463706,0.006587123,-0.059886158,-0.00920303,0.016525647,0.020324636,0.07506065,0.05600949,-0.101532646,0.035044447,-0.08064636,-0.04698969,0.0313784,-0.08920825,0.034891557,-0.017285716,0.06712726,-0.0015789347,0.033829555,0.035980918,-0.030494709,-0.017932046,-0.020886611,0.020656245,-0.0459152,0.010836852,-0.02275964,-0.10178764,-0.015359245,-0.01636528,-0.036444664,0.0090494165,0.048568115,-0.022724083,0.05383612,-0.021542147,-0.0054691155,0.043478258,-0.014478167,0.008247255,0.04308915,-0.08015301,-0.096583866,0.019290978,0.06599117,-0.038812086,-0.014413681,-0.08604674,0.026444003,-0.026329633,0.13030005,0.019238504 +1.14.14.46,"A cytochrome P-450 (heme-thiolate) protein. The enzyme catalyses an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl-[acyl-carrier protein], an intermediate in the biosynthesis of biotin. The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal. The mechanism is similar to EC 1.14.15.6, cholesterol monooxygenase (side-chain-cleaving), followed by a hydroxylation step, which may occur spontaneously [2].",384,1.0,-0.1367806,-0.009337428,-0.07441362,-0.002161781,-0.007130582,0.055227485,-0.1147122,0.06903806,0.015215196,-0.0629718,0.051778615,-0.06135513,-0.006897708,0.0169397,-0.038575046,0.02035386,-0.09946283,-0.011918462,0.012724159,-0.07328218,0.043159097,0.03504792,-0.029320875,-0.009420021,-0.064353645,-0.040479016,0.0844377,-0.07095774,-0.049296238,-0.05588197,-6.716599e-05,-0.028375503,0.036399245,-0.03185322,0.015198337,0.07305224,-0.011282302,-0.03810541,0.13509834,-0.013822299,0.04650309,-0.031863626,-0.04662126,-0.00011138534,0.021322047,-0.059608232,-0.012226059,0.01544842,0.020921985,-0.020013701,-0.07570964,0.0036912363,-0.031286854,-0.014799687,0.057285294,-0.03020863,-0.019678025,-0.07739015,0.005908014,-0.010422287,0.014434734,0.0012766797,-0.038321488,-0.0036266004,-0.062772356,-0.13486111,0.0474001,-0.05572725,0.011133257,-0.009377589,-0.061631348,-0.08358555,-0.041908503,0.044347227,0.0024560823,0.06677068,-0.06662849,-0.029660825,-0.013532587,-0.01098903,0.008357799,-0.034455664,-0.003743033,0.14520708,0.071050905,-0.051570423,0.03465231,0.015428918,-0.04202195,0.081813365,0.0048347046,-0.0041474914,-0.0046782484,-0.019976743,-0.07774875,-0.0051476993,0.005450093,-0.030042518,-0.017835138,-0.033254527,0.014587039,0.05412806,-0.0037853476,-0.047818135,-0.05292782,-0.048772838,-0.009313892,0.092425436,0.09736191,-0.0093581285,-0.013565277,0.00069492345,-0.00087844767,-0.095866755,-0.052551076,0.13451023,-0.054303207,-0.06493997,-0.015361523,-0.0015546835,0.004495412,0.01469218,-0.0054989816,0.08608617,-0.05568813,-0.041710775,-0.08450103,1.2825866e-33,0.06056533,-0.017381484,0.03367836,0.014826572,-0.008487537,-0.016022697,-0.12311653,-0.028128503,0.021098971,-0.05055752,-0.029388856,-0.056313172,-0.0024670707,0.038355473,0.009862561,-0.031981066,-0.03815853,0.025899936,0.0440288,0.023702277,-0.041434564,0.0076761246,-0.014352367,-0.025511958,0.0650525,0.016903311,0.013621083,-0.0007262936,0.005211263,0.02979642,-0.01766858,-0.08882957,-0.061575968,-0.02249806,0.03311901,-0.01175038,0.0026226505,-0.028350804,-0.06949351,0.11726239,0.027832305,-0.021066647,0.009726115,-0.061234184,0.04848783,0.006848061,-0.07379945,0.10419396,0.0021361231,0.110547125,0.027009126,-0.04512877,0.10786827,0.024214828,-0.04476133,0.04092174,-0.049947515,-0.009448923,-0.0074402094,0.04270636,0.11241578,0.057640105,-0.05672819,0.06337306,-0.03324214,0.046487063,-0.074515745,0.0006066854,-0.03301023,0.11511943,-0.030935789,0.06014869,0.07609558,-0.0071208226,0.009221294,-0.008401722,-0.080721624,0.10181644,0.015505827,0.043376464,0.017731445,-0.0067070425,0.038189188,-0.056036994,-0.02592949,0.021223838,-0.0052120527,-0.01020043,0.008382387,0.056286037,0.02918196,-0.09732422,-0.014214218,0.07297776,-0.037124578,-3.306678e-33,0.096165545,-0.10968819,0.05970615,-0.13178706,-0.044247452,0.03690211,0.04259752,0.03928554,-0.043976765,-0.04797835,0.02030848,0.03642045,0.05482446,-0.023163129,0.017613467,0.041639425,-0.03933148,0.025167715,0.0075980406,0.045455027,-0.035949152,0.0133506,0.026757,0.05223912,0.052346297,0.05466126,-0.043789886,0.0695169,0.06313806,0.0061993063,-0.039504938,0.023449074,-0.038968034,-0.030778391,-0.06653254,0.09974563,-0.04460821,0.052998737,0.0712721,0.05232135,-0.029638115,0.024455242,-0.011523819,-0.0014866715,0.083930045,0.05753322,-0.031490266,-0.007953915,0.02922935,-0.09849148,0.021070193,0.050173786,0.05704393,-0.009790511,-0.0075901127,0.04716308,-0.018126475,0.052421857,0.07182165,-0.08486975,-0.011883758,-0.042979106,0.07304005,0.027307473,-0.018614577,0.082874276,0.001787592,0.045074385,0.0026462115,-0.04783329,0.024356421,0.045436453,0.038685046,0.03725906,0.0025649802,0.013275983,-0.0053804186,-0.058419615,-0.021303423,0.0047301943,-0.023644967,-0.029402595,-0.037182797,-0.08427948,-0.06550109,-0.051479176,0.0043517887,0.032943424,0.048274126,-0.015199423,-0.043621864,0.03183714,-0.024455393,0.060652092,0.042009257,-4.7176677e-08,0.025078502,-0.10808636,0.037766077,0.010344077,0.019232005,0.05886328,0.030794412,-0.047874384,0.0667908,-0.09969636,-0.04796275,0.09122315,-0.021384558,0.03872606,-0.0049124076,0.017203256,-0.034998864,-0.013955283,0.054317333,0.00038577817,-0.11418095,0.003175491,-0.03170196,0.044290964,-0.017922474,-0.055405438,0.02458505,0.020213654,0.0398209,-0.07098783,-0.024245761,0.06444541,-0.03608963,0.0056854,-0.022665229,0.009423536,-0.06622727,-0.016687972,-0.00807826,0.07053186,0.057390884,-0.00075136236,-0.0866943,0.0011843706,0.09742801,0.0044576083,-0.0063559315,0.09614151,-0.019448744,-0.0034711068,0.0036817938,0.03252242,0.0076583438,-0.06170308,-0.06753561,0.019528188,0.004300464,-0.09631014,-0.03261851,-0.018552342,0.012079733,-0.00062596455,0.20506534,0.029850975 +1.14.14.47,"Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39).",384,1.0,-0.07860753,-0.022539845,-0.12242858,0.025828894,0.11930162,0.045183893,-0.04835529,0.0277457,0.097821325,-0.047287647,-0.0048490423,-0.07088315,-0.09623763,0.021325108,-0.040317345,0.0035446992,-0.094610475,0.019977205,-0.019067334,-0.024674216,0.016280008,0.08021881,0.00096421194,-0.042859823,-0.014286997,0.0037081654,0.04053274,-0.017078321,-0.012777034,-0.029420704,-0.016246138,-0.048719477,0.014718163,-0.025117395,-0.016937409,0.09307778,0.040413357,-0.10713803,0.002974422,-0.024113966,0.06030559,-0.02408334,-0.027814405,-0.038346604,-0.023149591,-0.0033025213,0.055406637,0.022773625,0.034565877,0.032318145,0.010096917,-0.035954263,-0.0317441,0.08810386,-0.025354583,0.035201237,0.057652105,-0.031248804,0.024395596,-0.014138503,0.041919544,-0.036086373,0.0012919694,0.02827821,-0.006760458,-0.052543223,0.012903624,0.0072236727,-0.09086867,-0.09650873,-0.037206296,-0.011061818,-0.041647017,0.05149882,-0.0119814295,0.11775199,-0.0106352065,-0.045369342,0.05049653,-0.019639822,0.008947533,0.026520358,0.028704144,0.1666511,0.023544244,0.020348843,-0.039980836,-0.0047080982,-0.040257756,0.016640572,0.024526453,0.0059093833,0.03013907,-0.06579004,-0.048917476,0.041082446,0.05636174,0.05258336,0.008857241,-0.034168966,-0.06675936,0.06489385,-0.029986696,-0.09533594,-0.039553326,0.0155305555,-0.046879508,0.08468751,0.117970206,-0.0022817361,0.031510033,-0.053616155,0.09890943,-0.01411532,0.030923706,0.059074353,-0.013477639,-0.026460355,-0.06820284,-0.023659965,-0.023604548,-0.0041776826,0.019427905,0.07552316,0.032249816,-0.013487338,-0.13196997,3.5714957e-33,0.13843879,0.03679333,-0.014049195,0.025630066,0.00040294853,0.040455744,-0.03366856,-0.01916126,-0.032620266,0.0012090799,-0.07832867,-0.06294978,0.045269795,-0.044378106,0.0026786376,-0.019380333,-0.010650113,-0.054696307,0.024978016,0.06764885,0.038740546,0.074806824,-0.031138506,0.0012426375,0.061108984,0.07038022,-0.036504198,0.008488292,0.03891757,-0.026406778,0.05467666,-0.08984887,-0.10900527,0.008250668,0.1159799,-0.046937093,0.014399422,-0.0016611887,-0.101253614,-0.010528118,0.016634945,0.03487848,-0.05735168,-0.029619753,0.11778815,-0.10520699,-0.03795632,0.07964726,0.004666939,0.081876814,-0.015730726,-0.015649248,0.11144961,-0.024833638,-0.06194555,0.012451683,-0.04528924,0.04889203,0.024422817,0.078820504,0.05750702,0.036618803,-0.03460919,0.09598917,0.026798408,0.07024717,-0.011183363,-0.060536202,0.029201234,0.06610106,0.0013275837,0.018859174,0.033289876,-0.0013300047,-0.005321146,-0.057885222,-0.07716271,-0.051398106,0.049723707,-0.04794818,0.0303593,-0.06920015,0.018341271,-0.01907745,-0.06923117,-0.03744939,-0.046742834,0.014425618,-0.016723406,-0.052522585,0.0781069,-0.04225048,-0.024895549,-0.07754281,-0.003435964,-2.822849e-33,0.09407006,-0.09574987,0.030855207,-0.08776112,-0.040635932,0.110938914,-0.010642056,-0.05246549,0.0024693,-0.023360623,0.11409378,0.0077970703,-0.038935453,-0.039262753,0.042014685,0.028319642,-0.0030952494,0.017909236,0.043900277,-0.028558409,-0.043987595,-0.007136438,0.01151303,0.030667642,0.05816432,0.016457798,-0.05939287,0.013068119,-0.015503616,0.003696923,-0.022606932,0.025413556,-0.07381377,-0.050938495,-0.029703924,0.00088985934,0.00040441044,-0.030468825,0.043988496,-0.017568484,0.02279872,-0.03271766,0.005954256,0.08277734,0.035136014,0.061355427,-0.1539939,0.06320352,0.007800026,0.04644689,-0.010332241,-0.023388715,-0.02745549,-0.053845022,0.057699665,-0.025246363,0.06801277,0.02786804,0.023818731,0.0018340084,-0.0067303455,-0.04962058,0.05002187,0.12087365,-0.017500088,0.098549545,0.008368622,0.0950056,0.03186235,-0.014371915,0.05965309,-0.021047149,0.05133471,-0.005294216,-0.0034786975,-0.037914302,0.062374424,-0.0005037162,0.040303536,0.0014588359,-0.023180675,0.005045028,-0.02972883,-0.0812734,0.043676976,0.009435404,0.0020388034,0.08666475,-0.021369312,0.020616395,-0.029373743,0.021722276,-0.011069459,-0.033765692,0.041070685,-3.8091652e-08,0.0075197592,-0.05328658,0.04514458,-0.067685224,0.003930604,-0.00073706615,0.08589089,-0.0051355464,-0.015730716,0.040376164,0.005697346,0.07855982,0.008087588,-0.036880244,0.08775073,-0.02450104,0.039542023,0.020219365,-0.03758236,0.004834499,0.0054840464,0.031838145,-0.103186026,0.041304234,0.0051867794,-0.13255781,-0.016983127,-0.030718885,0.06376524,0.02335271,-0.011841775,0.013097222,0.012482288,-0.0592627,-0.03560627,-0.0042137806,-0.027998999,-0.018432012,-0.036774535,-0.0021513102,-0.07290667,-0.0010967065,-0.035601035,-0.09249464,0.020577129,0.046508774,0.07012135,0.028631119,0.022006048,0.0022625471,-0.022535402,-0.028915511,0.060764283,-0.077965975,-0.12291669,0.03576351,0.035972804,-0.046348646,0.025558438,-0.01940176,-0.036932524,-0.033867233,0.13997047,-0.03372056 +1.14.19.51,A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of the quaternary benzylisoquinoline alkaloid magnoflorine in the plant Coptis japonica. It is specific for (S)-reticuline.,384,1.0,-0.063299604,-0.012114511,-0.09372526,-0.02010327,0.061031252,0.09527448,-0.007043667,0.10360214,-0.009449656,-0.02530769,0.025093477,0.0010048333,-0.020449027,0.045630336,-0.06631005,0.037974566,-0.06521126,0.025963763,-0.004776733,-0.11696996,-0.000169235,0.056954887,0.02828913,0.008851598,-0.0029930018,-0.002627955,-0.01822986,0.061995737,-0.0086405175,-0.031775817,-0.01549797,0.032163482,0.021272916,-0.07018209,0.023836942,0.084111646,-0.063303374,-0.057142973,0.043179534,0.008343043,0.080999285,0.005909194,-0.037818696,0.028351476,0.012076023,0.01134301,0.02071805,0.0743623,0.030309176,0.016284652,-0.022743713,-0.026621174,-0.09190718,0.047225546,-0.035308953,-0.006301098,0.020658474,-0.009637759,-0.03264931,-0.013797504,-0.03510308,0.04057047,-0.0053768004,0.021356417,0.06293883,-0.061735958,-0.09484404,-0.043986503,0.06361531,-0.09147323,-0.005955168,-0.10944167,-0.06099612,0.032858543,-0.08748956,0.089003816,-0.07238398,-0.0030649002,-0.012514728,-0.005467334,0.085832074,-0.011933516,-0.0010210959,0.116449684,0.051869888,-0.025172379,-0.0045982506,0.023373421,0.026369272,-0.013643273,0.006130669,0.022669666,-0.037138194,-0.014645708,-0.13928032,0.03868285,-0.007313115,0.018012503,-0.05350237,0.020645892,0.0666992,0.011211872,0.016511654,-0.07309667,-0.08849146,-0.015865719,-0.03295856,0.03524036,-0.0042819083,-0.04965075,-0.04304349,-0.02486329,0.019421639,-0.078895465,0.054546587,0.1013574,0.023018202,-0.04433585,-0.012218673,-0.02447163,-0.027100472,-0.018969793,0.011106218,0.001145281,-0.011589879,0.038225044,-0.16740915,3.615117e-33,0.08695861,0.02393885,0.020242402,0.025965651,-0.019951047,-0.04063465,-0.061912283,-0.025233593,-0.03501572,-0.010615851,-0.07919603,-0.021835849,0.03761676,-0.061847802,-0.03482138,-0.02668905,-0.02023909,0.039520606,0.01809423,0.009186509,-0.022303484,0.058626205,-0.06954139,-0.013998421,0.05052637,0.07744004,-0.0027611307,-0.028727796,-0.005312442,0.010044747,-0.030236159,-0.038226556,-0.10934423,-0.033923056,0.03320013,-0.0669206,-0.01447296,-0.07010767,-0.081753656,0.021937212,-0.04064469,0.007004017,0.03176469,-0.04514433,0.075011246,-0.03702576,-0.10496065,0.038682107,0.024022056,0.05674849,0.0880818,-0.03320221,0.14352195,0.02849972,-0.057781227,0.025959658,0.008932752,0.03900587,-0.017639294,0.058673605,0.06958479,0.04038104,-0.08180153,0.024376474,0.07610617,0.050500676,-0.027474683,-0.05722389,0.026962807,0.15421109,-0.0710285,-0.016013239,0.06399706,-0.006812799,0.057840355,-0.04116744,-0.0048076585,0.05990149,-0.0141654145,0.012665297,0.010284604,-0.034973048,0.011477446,0.00014300885,-0.044851203,-0.054893874,0.047597736,0.0019232918,-0.0111192195,-0.02181337,0.09573033,0.024222612,0.015727362,0.07722501,-0.011920082,-2.9407574e-33,0.042216815,-0.10396719,0.023072079,-0.0678158,-0.08812504,0.055456538,-0.032155506,-0.019061457,0.02434097,0.020332165,0.06675846,-0.06937817,0.033521954,-0.0020451343,-0.022715788,-0.01042311,-0.0018388914,0.0792859,0.010901236,0.032524366,-0.06280957,0.03880834,0.041723162,0.04644146,0.0066841324,0.046419263,0.041731294,-0.020827679,0.042297028,0.02116333,-0.047901563,0.006015236,-0.07494834,-0.069054835,-0.044821385,0.0035273773,0.03876258,0.021729885,0.025110384,0.03823518,-0.020283507,0.10318969,0.09131935,0.047677103,0.022847697,0.016647179,-0.072546944,-0.007041739,-0.020122085,-0.062356543,0.04398395,-0.0057495786,-0.016969936,0.037014294,-0.007948721,0.0053269775,0.01220629,0.0330953,0.0025898663,-0.00880629,-0.009925631,-0.08603305,-0.028733175,0.017485017,0.05260144,0.08564734,-0.03431432,0.051529687,0.054491907,0.020414414,0.06968033,0.053677373,0.087963216,0.0875586,0.023662237,0.0020668735,0.03275225,-0.008181605,0.04818884,0.022167599,0.014842274,0.011360377,-0.06342298,-0.045283288,-0.017695978,-0.105881765,-0.06169662,0.09951159,0.07340775,-0.06646881,0.008081866,0.037212845,-0.034758486,0.07181824,0.0364981,-3.6658182e-08,0.0023053621,-0.043381006,-0.042232174,0.0056685978,0.013872655,0.0397158,0.009213065,-0.032208215,0.082360834,-0.0278257,0.043848004,0.07495446,-0.003313892,-0.027176846,0.05347813,0.025413247,0.006819248,0.056686416,0.02153548,0.081028126,-0.003286454,0.043260742,-0.0697338,0.017750135,-0.01767504,-0.0943234,0.037719555,-0.00546904,0.03965903,0.036143698,-0.009816898,0.016696928,-0.021479724,-0.035019312,-0.07379422,0.019394131,-0.03705565,-0.059345502,-0.017836682,0.009058286,-0.020312572,-0.05628486,-0.061356936,-0.033502642,0.01931024,-0.03397906,0.043836396,0.03942053,-0.032881416,-0.028361779,-0.024676573,-0.009797683,0.033564437,-0.1457329,-0.10380467,-0.034238566,0.06136791,-0.06408987,-0.031697705,-0.124417275,-0.013312406,0.013317315,0.21941888,0.003640724 +1.14.99.54,"This copper-containing enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner. The cellulose fragments that are formed contain a D-glucono-1,5-lactone residue at the reducing end, which hydrolyses quickly and spontaneously to the aldonic acid. The electrons are provided in vivo by the cytochrome b domain of EC 1.1.99.18, cellobiose dehydrogenase (acceptor) [1]. Ascorbate can serve as the electron donor in vitro.",384,0.99999994,-0.09351927,0.01377271,-0.060176328,0.028455824,0.029817823,0.020394247,-0.008448692,0.024504201,0.025107771,0.007568001,0.083918534,-0.0607596,-0.049975704,-0.0067413677,-0.11788897,-0.029327517,0.049402267,0.03172313,-0.06198009,0.03566324,0.08601389,0.023345852,0.0032836958,-0.050641984,0.12786952,0.014607551,0.01962858,-0.06505999,-0.03755353,-0.06366082,0.019927733,-0.028034097,0.009085495,0.05561938,0.048088603,0.099731594,-0.0114748785,-0.050972365,0.09013451,0.008785591,0.05051824,-0.04302438,0.05311831,-0.017832559,-0.025475504,-0.027617946,0.10726771,0.021219747,0.03734985,-0.034776352,0.0091092065,-0.027023336,0.028942915,-0.0075984537,0.021986382,0.043000028,0.030660909,-0.048022453,0.0035640823,0.03506518,0.023660788,0.011038851,-0.04708588,0.046311636,-0.008267669,-0.09553262,0.020912949,-0.056248464,-0.03352856,-0.08843355,-0.00031714712,-0.02513219,-0.03466299,-0.014242377,-0.008747699,0.11647861,0.035542436,-0.0960666,0.03735719,0.0030729447,0.061019994,0.043128084,0.07167759,0.060300466,0.04537217,0.025845025,0.02203694,0.04354228,-0.049890533,-0.05989211,0.0134841455,0.023214819,-0.054366894,0.011069293,-0.095793076,0.037355445,0.11852446,0.062396597,0.03221448,-0.073603936,0.027291173,0.09488559,0.044196244,-0.06367443,-0.015758254,-0.02517883,-0.023675265,0.10495394,0.07011635,-0.050274063,-0.015199906,-0.0037085593,-0.075512156,-0.006322045,0.04248112,0.092928335,0.05302384,-0.05146713,-0.08292884,-0.04260113,0.000824588,-0.025267916,-0.010704963,0.06054679,-0.03943045,0.038237106,-0.02484181,9.557661e-34,-0.0076777856,0.03758276,-0.041941494,-0.046204377,0.012570753,-0.011700438,-0.061288774,0.013107962,-0.052012894,-0.04629279,-0.074415,-0.02258908,0.04813399,0.10788043,-0.06182698,-0.008676629,-0.056557864,-0.08822876,0.11253378,0.0118660405,0.035748836,0.021568619,-0.029837824,0.061298598,0.028618155,-0.037270047,-0.0031966134,0.026004804,0.06451141,-0.034618057,0.072299555,0.013356806,-0.069723,-0.035380464,0.0039757215,0.014868655,-0.033124037,0.05832558,-0.020193437,0.04824322,0.0068009226,0.017514655,-0.011787287,-0.026397016,0.05262928,-0.07104956,-0.051030166,0.044579946,0.031295627,0.03551384,0.087290354,0.046146102,0.08637754,-0.022944652,-0.05606903,0.041479584,-0.031492047,-0.010080519,0.023362419,0.033912797,0.06632769,0.07268386,-0.085445456,0.026257487,-0.05419161,0.023366965,-0.008449735,-0.03947999,-0.0035205348,0.026323445,-0.11915789,-0.029408408,-0.025927546,-0.011738406,0.009222256,-0.0030039083,-0.10787484,0.006531749,0.08004575,-0.044863738,0.058768224,0.02122313,0.03748601,-0.019856412,-0.018899487,-0.046653967,-0.04168098,-0.012514213,-0.025897166,-0.019178888,0.038837954,-0.07390242,-0.093507424,-0.043692276,0.039553035,-2.635059e-33,0.14782842,-0.089293346,0.021609422,-0.026501741,-0.006588728,0.0150008155,0.02055027,-0.019269682,0.01854356,-0.029551333,0.10350866,0.03592161,0.030391173,0.0105995545,0.068764664,-0.009036984,-0.13860865,0.114400074,0.0011340834,0.025872534,-0.0019934385,0.06680195,0.060905557,-0.01760106,0.050360315,-0.016617293,-0.072876655,-0.03238007,0.072542205,-0.028425278,-0.026573986,0.02282604,-0.027062865,-0.043331064,-0.035101973,0.088025406,-0.06545312,0.0019551006,0.061309647,0.027063135,-0.0074350447,-0.005653213,0.03443594,0.04415228,0.040308002,0.040255286,-0.09339384,0.02104372,-0.015766898,0.040709943,0.01495545,0.05439083,-0.028797235,-0.019900624,0.065690964,0.070189126,0.027205575,-0.01881543,-0.012307569,-0.07304966,-0.113673344,-0.005557482,0.03559909,-0.033832107,0.068737015,0.03889332,-0.027070086,0.09374523,-0.017676812,-0.04104724,0.09673287,0.0635201,-0.056260943,-0.034880076,-0.044514775,-0.047717694,-0.07594194,0.058818106,-0.028466986,0.03729078,0.031090846,0.04568714,0.052780643,-0.058929138,0.020610835,-0.076809905,0.014512511,0.09390885,-0.043320123,-0.0030676483,-0.041879833,-0.059935693,0.027277494,0.048778385,0.089065626,-3.960461e-08,-0.05502361,0.036772367,0.04141142,-0.12064203,0.017920915,0.0054765996,0.05149524,-0.0027525455,0.038735192,-0.059577446,-0.008218949,0.12425187,-0.028094351,0.042098086,-0.023004552,0.020478163,-0.061024472,-0.067656375,0.019481413,0.01435582,-0.044149075,-0.03296907,-0.09591085,0.044970173,-0.026564294,-0.051577505,0.04028118,0.0074055293,-0.033926006,0.024840815,-0.0016300244,0.02180841,-0.007864717,-0.06660369,-0.045236625,-0.016814703,-0.037998717,-0.06698878,-0.010754426,-0.01091942,0.013077119,-0.13123581,-0.016648656,-0.011653623,0.014614777,-0.0073591205,0.007153547,0.012068584,0.0005478271,0.03531994,-0.022033025,-0.065078065,-0.05174702,-0.07781951,-0.0682359,0.038443774,-0.010749635,-0.009282813,0.021936564,-0.05054966,-0.019960275,-0.025939355,0.13883391,-0.013362668 +1.14.99.55,"The enzyme cleaves starch in an oxidative manner. It releases fragments of starch with a D-glucono-1,5-lactone at the reducing end. The initially formed alpha-D-glucono-1,5-lactone at the reducing end of the shortend amylose chain quickly hydrolyses spontaneously to the aldonic acid. In vitro ascorbate has been found to be able to serve as reducing agent. The enzyme contains copper at the active site.",384,1.0,-0.032574687,-0.027802465,-0.011434792,0.064458646,0.043910667,0.02766012,-0.004136015,-0.029160509,-0.013033554,0.011403826,0.05023435,0.012738103,-0.06162381,-0.045100525,-0.11834173,0.0323667,-0.0021602258,0.022054132,-0.07836106,0.019024286,0.08871859,-0.029212872,-0.010991875,0.04475096,0.079036795,-0.021652699,0.054910105,-0.09527358,-0.02885067,-0.070203386,0.042475224,-0.09730619,0.036950927,0.09400967,-0.0046267984,0.07019976,-0.025859918,-0.067862235,0.026797691,0.018169377,0.034810442,-0.0759654,-0.0148709025,0.021129893,-0.02811654,-0.037228532,-0.041150488,-0.026217539,0.04024564,-0.004018144,-0.03884606,-0.07218105,-0.05408377,0.028154843,0.006693212,0.07788286,-0.039073713,-0.03654548,-0.075225756,0.072956055,0.08310427,0.046361223,-0.0889802,0.006735078,0.024027264,-0.04411579,-0.025491778,-0.03231042,-0.019319482,-0.051323194,-0.02915834,-0.049503613,-0.005292895,-0.00926452,0.045060836,-0.013967987,0.043530904,-0.08768055,0.0872792,-0.02140272,0.08148776,0.026284147,0.060588446,0.07638615,0.013518769,-0.013401488,0.07368652,-0.014975761,0.02697011,-0.00925042,0.036481842,-0.00036863625,-0.11356885,0.012798672,-0.006279109,0.0013474032,0.07025826,-0.041563496,0.036249787,-0.033282973,-0.015091484,0.06816658,0.02122956,-0.08323617,-0.005424456,0.046038125,-0.005862517,0.033800125,0.032820296,0.013994457,0.013191979,0.059970308,-0.049830288,0.037180375,-0.01082462,0.11977346,0.024496453,-0.034559693,-0.060316786,-0.0381516,0.012306134,0.02138572,0.0817747,0.06388784,-0.05989877,0.053516906,-0.01785569,1.0520096e-33,0.05529726,0.024547525,-0.018116042,-0.041914403,0.033662044,0.006665987,-0.10751649,-0.0028623035,-0.038221147,-0.048929404,-0.023329088,-0.06608258,0.02544593,0.093063466,0.057060353,-0.08779211,0.010180741,-0.010511095,0.089680575,-0.006076737,-0.025111018,0.066812605,-0.04373825,0.028233705,-0.0015744317,-0.0191713,-0.0668302,0.050589535,0.05445504,0.0073672123,0.0137705365,0.016126981,-0.093169086,0.026956199,0.030038208,0.053684536,-0.035180725,0.050912034,0.01918448,0.025361957,0.043243617,0.024762195,-0.05706182,-0.04790799,-0.0047380156,-0.120158285,-0.027785338,0.088381425,0.029063486,0.05155235,0.07860525,-0.026212767,0.052666306,0.058416504,-0.03518614,0.017674224,-0.043365132,-0.054151356,0.06917681,0.03479751,0.03228973,0.037533756,0.0033242144,0.055738807,-0.004916831,-0.017760854,-0.031838886,-0.005300278,-0.07898319,0.043668836,-0.091563046,-0.034424003,0.010737593,-0.04328734,-0.052727934,-0.014776138,-0.021828048,0.042511057,0.0058674854,-0.00768843,0.03396728,0.033297073,0.0385047,0.016324723,-0.023597723,0.018107558,0.012874691,0.0026276412,-0.011856705,-0.065885976,0.0031391364,-0.02369724,-0.03107368,-0.05285686,0.048556756,-2.2765816e-33,0.14081526,-0.14261432,0.013540752,-0.007829417,-0.0111769885,-0.008659012,0.05888074,-0.054645423,-0.03039632,-0.0034777194,0.063503504,0.0029973844,-0.008666778,-0.06999133,0.05009941,-0.026746891,-0.06735141,0.10647694,-0.01431272,0.0053467383,0.009092522,0.1244924,0.011367793,-0.022683155,0.03234227,-0.058106195,-0.038528822,0.022975972,0.021352967,0.0077359593,0.013962311,-0.010237023,-0.019349856,-0.028487893,-0.050480522,0.1311347,-0.08318776,0.042939305,-0.0007396799,0.044535242,0.0200528,0.0150182145,0.018533047,0.0488184,0.058287617,0.07268503,-0.099980675,-0.022140348,-0.046020713,-0.005978384,0.06987551,-0.044859987,0.006162684,-0.008386323,0.030552624,0.064855956,0.015272059,-0.0050657666,-0.045317058,-0.030067516,-0.07375035,0.008795866,0.01992384,-0.07367013,0.07740326,-0.040363617,0.0016509283,0.0935748,0.024044381,-0.054282453,0.077204354,0.0806449,0.026895799,0.062368978,0.038373806,-0.009842025,-0.099710464,0.018560838,0.0037718243,-0.0025841377,-0.030825835,0.03739749,0.03323032,-0.06892052,-0.08280408,-0.06324483,0.013685332,0.11768982,-0.029671617,0.027987959,-0.037924007,-0.054492332,0.040543158,0.056917273,0.051763624,-3.761228e-08,0.02931836,-0.06478469,0.04610386,-0.050811604,-0.0016716492,0.024338208,0.054610677,0.008935316,0.04766359,-0.063008524,-0.08835423,0.13001524,0.002609015,0.050013345,-0.06851467,-0.058765892,-0.0130592575,0.015601878,-0.026936295,-0.024533706,-0.088156424,0.009124695,-0.08691267,-0.029427763,0.0058544283,-0.08179345,0.06473993,0.09000531,-0.14072964,-0.039765745,0.03727121,0.057908572,0.013620236,-0.08368576,-0.010600151,0.06945858,0.051379047,0.00069532805,0.04801492,0.05370452,-0.014107128,-0.09914375,0.017632972,-0.027074281,-0.046471763,-0.0021224683,-0.008059313,-0.0009730139,0.056152847,0.07515098,0.0052748783,0.033484455,-0.09220607,-0.06632775,-0.052532718,0.012754566,-0.008997359,-0.038531926,0.029440837,-0.10001953,-0.005508992,-0.03493103,0.13460499,-0.007829189 +1.14.99.56,"This copper-containing enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner. The cellulose fragments that are formed contain a 4-dehydro-D-glucose residue at the non-reducing end. Some enzymes also oxidize cellulose at the C-1 position of the reducing end forming a D-glucono-1,5-lactone residue [cf. EC 1.14.99.54, lytic cellulose monooxygenase (C1-hydroxylating)].",384,1.0,-0.040929954,0.00059083675,-0.027345506,-0.0037708113,0.09846318,0.0139278965,-0.018348757,0.028650919,0.054270852,0.00046310484,0.049681127,-0.02738797,-0.07038475,-0.00071100186,-0.13018984,-0.053121943,0.00074690493,0.06132367,-0.0527421,0.016858168,0.09323877,0.04467469,-0.0037859383,0.002882464,0.086346,0.0045178058,0.002743188,-0.06338851,-0.016806152,-0.018386273,-0.004137693,-0.011350276,-0.002182521,0.08294108,0.050736956,0.092782974,0.019943273,-0.040729385,0.09026517,0.0009583305,0.032861788,-0.012737271,0.058788665,-0.020008964,-0.019345898,-0.016181722,0.04398926,-0.00050140807,1.0875431e-05,-0.031837996,-0.014938375,-0.04188282,0.008887746,-0.0023484516,0.10513384,-0.0069767106,0.040972423,-0.059003826,0.02840101,0.0299201,0.020063695,-0.0046961596,-0.03816456,0.041052897,-0.0045012697,-0.098446965,0.026300402,-0.064999714,-0.06255367,-0.07139018,-0.032653835,-0.0040662563,-0.06508064,-0.0064981407,-0.03893035,0.1029855,0.069268495,-0.09360023,0.05776505,0.014056961,0.059591208,0.083824344,0.09988069,0.025247803,0.017914211,-0.03695751,0.04730915,0.0041201515,0.012073334,-0.096881315,0.032693826,0.063987024,-0.075525835,0.010851646,-0.07252811,0.05451288,0.07810822,0.049042527,0.029577734,-0.07523723,0.021886313,0.069739245,0.057025734,-0.090035625,-0.036765087,0.021006647,-0.0059180986,0.12198786,0.032620057,-0.027611842,0.0021503838,0.019835334,-0.061399147,0.022210233,0.0123005435,0.0497736,0.0726927,-0.038431916,-0.09982874,-0.0008745918,-0.020139063,-0.037035774,0.032588497,0.020832421,-0.054688875,0.044744007,-0.012442809,7.631848e-34,-0.01334208,-0.0021125178,-0.05325722,-0.06637021,0.06476721,-0.029618848,-0.03977106,0.014598679,-0.0050184326,0.015002728,-0.053128954,-0.007946101,-0.005736019,0.07896923,-0.035982404,0.010617166,-0.015790328,-0.07001422,0.06406129,0.029919421,0.015907008,0.024640962,-0.015712727,0.052534495,0.044250138,-0.018816298,-0.004858035,-0.022020373,0.08642883,-0.018517368,0.06533396,-0.006495305,-0.044020124,-0.015333409,0.037549865,0.02184424,-0.038079508,0.07596637,-0.024125367,0.07278123,0.041645676,-0.004522608,0.0065850695,-0.02961417,0.037863873,-0.084797055,-0.043815244,0.10662227,-0.00026510435,0.036784217,0.09039374,0.07643818,0.04165306,-0.046442132,-0.040244237,0.027887175,-0.033896614,-0.02294957,0.06040487,0.02296601,0.01988046,0.0647553,-0.1141514,0.0065929517,-0.010228569,-0.025606371,-0.04391666,-0.015287747,-0.026163584,0.014095486,-0.0907216,-0.049176548,-0.0022126008,0.021858351,0.03939412,-0.069955654,-0.08307949,-0.019149872,0.08922858,-0.044975597,0.020560527,0.04010089,0.060783237,-0.056826174,-0.029942805,-0.05834483,-0.094780736,0.035342284,-0.045957427,-0.052434724,0.031491164,-0.038144812,-0.083460696,-0.02337032,0.0018543035,-2.2368664e-33,0.11456816,-0.07181927,0.009780308,-0.065017186,-0.013114872,-0.022124402,0.0025280025,-0.049442664,0.021230683,-0.055607192,0.08828246,-0.009223011,-0.017839745,0.038380247,0.078051016,0.043963008,-0.13077368,0.12951963,-0.054658927,0.013013892,0.015517855,0.03473507,0.05622675,-0.01113404,0.06142373,-0.0011615211,-0.066502474,0.011989249,0.05937267,-0.03023896,-0.019704174,-0.0017047091,0.039316837,-0.04052237,-0.053734496,0.03985606,-0.06744494,-0.0357366,0.08431882,0.059302025,0.024300573,-0.0031714395,0.030172437,0.042876255,0.0211974,0.011526944,-0.10036865,0.0013789809,-0.023197042,0.011752235,-0.00044579036,0.052132096,-0.03393644,-0.01997855,0.055545073,0.08831721,-0.022001974,-0.0026077565,-0.03431535,-0.04443679,-0.04831373,0.023469053,0.006999888,0.019759104,0.12543134,0.057616565,-0.040018775,0.073924124,-0.0070146667,-0.02959651,0.07040263,0.050571196,-0.041904323,-0.062047157,-0.04514634,-0.03152109,-0.08193177,0.04672832,-0.004050462,0.034320533,0.056389585,0.037884958,0.062370304,-0.08970559,-0.015183832,-0.1017933,-0.012192118,0.1008183,-0.03479158,-0.0034530316,-0.03254745,-0.070184454,0.03751912,0.08996185,0.12154502,-3.899256e-08,-0.05317214,-0.004033512,0.04587668,-0.09370613,-0.00077059976,0.015624133,0.048574373,0.024057185,0.040928483,-0.04829775,-0.011764135,0.120081306,-0.07097268,0.0051317043,-0.0049683955,0.019678183,-0.054957274,-0.06844566,0.0071250875,0.03994388,-0.049446683,-0.02622493,-0.054937456,0.063912675,-0.062289644,-0.057176583,0.019838437,0.021948263,-0.07501834,0.03527486,-0.015410862,0.074484356,-0.018275103,-0.08017059,-0.08113116,-0.0087821605,-0.017571226,-0.072637424,-0.031940654,0.020585243,0.042167537,-0.09996174,-0.035863142,-0.038563,0.02462267,-0.029804047,-0.009642336,0.018617136,0.019712452,0.022605093,-0.011231332,-0.015163343,-0.07178292,-0.055462383,-0.029996876,0.006721851,0.015307567,0.02060103,-0.020508107,-0.052403633,-0.035368916,-0.022529347,0.18201753,-0.013882986 +1.14.99.57,"The enzyme, characterized from the bacterium Mycobacterium tuberculosis, is involved in heme degradation and iron utilization. The enzyme binds two stacked protoheme molecules per monomer. Unlike the canonical heme oxygenases, the enzyme does not release carbon monoxide or formaldehyde. Instead, it forms unique products, named mycobilins, that retain the alpha-meso-carbon at the ring cleavage site as an aldehyde group. EC 1.6.2.4, NADPH-hemoprotein reductase, can act as electron donor in vitro.",384,1.0,-0.054630555,0.012804219,-0.08486602,0.016017746,0.072187446,-0.025439087,0.01515654,0.12342838,0.0056007295,-0.012908057,-0.065773904,-0.011507087,0.014291109,0.03802414,-0.046962943,0.063237846,-0.029944206,-0.005035926,-0.03767129,-0.023130236,-0.014673232,0.08474982,-0.025299834,-0.0511231,0.068424866,-0.017694395,0.039642103,0.0028244492,-0.072757594,-0.08181532,-0.009896281,-0.07733501,0.053535666,-0.031397842,0.07392944,0.074863605,-0.016747972,-0.09461681,-0.005020817,0.03535089,0.050355766,-0.06405903,-0.046315122,-0.019633966,-0.012511227,0.021557119,0.017611448,0.076972395,0.016975414,0.05897402,-0.024532573,-0.022044962,-0.081146605,0.07287505,0.019045416,0.0007028689,0.020639079,0.0043002814,0.016889244,-0.0047396966,0.042948555,-0.023217807,-0.0153532745,0.01826252,0.039868455,-0.061702065,0.045774274,-0.042709637,-0.039388973,-0.06107364,-0.05016473,-0.02193021,-0.077396594,0.058111016,-0.011524058,0.043887634,-0.018551094,-0.03945912,0.027774142,0.043480285,-0.05052721,-0.011463258,0.007021632,0.040503297,0.042101815,0.08474428,0.044176616,-0.021033471,-0.054113522,0.045948513,-0.038750168,-0.017117351,0.025218058,-0.04263895,-0.09405079,-0.012154872,0.11681379,0.09671736,0.028210344,-0.02151666,-0.0035343473,0.033243217,-0.031365104,-0.049749278,-0.08278464,0.015553307,-0.04259314,0.060782835,0.10521281,-0.008338601,0.025943521,-0.009561768,0.06402617,-0.0109272,-0.007350123,0.13056178,0.06643393,-0.027615365,-0.09295313,0.029637001,0.005037276,-0.020831598,0.06297,-0.01022493,-0.031423274,-0.013911817,-0.0880208,2.3258756e-33,0.033152368,-0.027447669,0.011557292,0.035144452,0.000181734,-0.011202849,-0.15966369,0.012017479,-0.049797546,-0.033662416,-0.031732522,-0.0718758,0.06994202,0.006547858,-0.06468671,0.03261912,-0.0028034518,-0.034341138,0.04186489,0.066005155,0.0228411,0.00048001346,-0.02097719,0.080022,0.021577938,0.05606021,-0.033970363,0.031398233,0.01674689,0.0050484757,0.024235774,-0.041232664,-0.1001153,-0.048488524,-0.003214272,-0.023884466,-0.03173504,-0.00854845,-0.004055927,0.011261976,0.014534274,0.038214736,-0.013227553,-0.036602523,0.085836984,-0.08988022,-0.03634062,0.02502803,-0.034746762,0.03174645,-0.014458071,-0.04176972,0.096769065,-0.034261454,-0.016604332,0.007254652,-0.019077474,0.042431366,0.063174054,0.05313317,0.0644998,0.08373444,-0.061057474,0.117821194,-0.02641075,0.022137316,-0.011384043,0.015467237,0.036846396,0.046907708,0.018898921,0.04067194,0.026651923,-0.047748234,0.012211883,-0.04241037,-0.07528593,-0.01821602,0.08715951,-0.08457312,0.084610954,0.008963791,-0.016387274,-0.082297854,-0.054299355,-0.03534863,-0.0309026,-0.05947968,-0.04746938,-0.020143604,0.07412042,-0.07982029,-0.07270184,-0.083952546,-0.018045472,-2.3346886e-33,0.12410401,-0.07967453,0.04161152,-0.06885299,0.013783575,-0.006271534,0.035922155,-0.015092607,-0.0055458425,-0.011077896,0.0922942,0.020189177,-0.034956835,-0.0018293088,0.036502,0.0037435465,-0.04701772,-0.026391473,-0.018159179,-0.032829467,-0.012593824,0.030735405,0.03786289,-0.04735482,0.0041142097,-0.023258688,-0.124555,-0.0035433155,0.14548373,0.051632307,-0.06629213,0.029290814,-0.043132503,-0.06932268,-0.05512738,0.010957915,-0.04592861,0.007878661,0.11890744,-0.045364767,0.0074118203,0.019170973,-0.0057959743,0.002262994,0.05651306,0.0511538,-0.10361376,0.026386794,0.03585904,-0.02601147,0.009619525,0.030607399,-0.04792419,-0.003996897,0.024580188,0.024503415,0.08718981,0.0035510585,0.006287245,-0.021526752,-0.06859999,-0.023697948,0.050901834,0.048692837,0.0066060587,0.08922409,0.001795948,0.09984419,0.05569691,-0.02878728,0.08215551,-0.02800792,0.042461686,-0.010147588,0.0050172727,-0.099081874,-0.0071538636,0.07677575,-0.005499358,0.024288753,-0.083593376,0.008354968,-0.010571369,-0.09246349,0.0501144,-0.08690193,-0.040016614,0.09782645,-0.05265278,0.019229243,-0.044342287,0.04088453,-0.039287828,0.03305967,0.020238128,-4.0002195e-08,0.010990844,-0.05062581,0.08875595,-0.018322593,0.05529512,0.007859118,0.03627971,0.03297572,0.08548516,0.034011856,-0.0046251263,0.11095712,0.023121903,-0.038689464,0.057508778,0.056043155,-0.022792839,-0.080455355,-0.029305326,-0.048325825,-0.0276717,0.02289096,-0.028197056,0.0978002,-0.03754236,-0.066927075,-0.00652619,0.0013613108,-0.00914735,-0.0071263798,-0.051477067,0.09698725,0.016520828,-0.07017901,-0.09380861,-0.04839658,-0.02340361,0.044213176,0.013715511,0.020416752,0.012847752,-0.050342955,-0.074478984,-0.008877555,0.028925767,0.046223864,0.037007418,-0.023711782,-0.023623945,-0.032223754,0.044697814,-0.0071936743,-0.0050936565,-0.01242246,-0.050474588,0.10811314,0.015313151,0.0065147756,0.06886995,-0.06417093,0.036991205,-0.035127874,0.17412022,-0.051077463 +2.1.1.340,"The enzyme, characterized from Hordeum vulgare (barley), catalyses two successive N-methylation reactions during the biosynthesis of gramine, a toxic indole alkaloid.",384,1.0,-0.02279936,-0.024673315,-0.02758773,-0.051965017,-0.02492279,0.08655013,-0.052825727,0.022155294,0.033803873,0.023293223,0.026604999,-0.055782866,0.0006266851,-0.08301282,-0.052012984,0.06286121,-0.035903446,0.04675882,-0.03845067,-0.106949665,0.042004105,0.07190587,0.044695202,-0.023490036,0.014115353,0.01347043,0.010309382,-0.035636183,0.030862367,-0.030241165,0.016116759,0.04683192,0.007464517,-0.021305488,-0.023639884,0.04123057,0.010897937,-0.028153626,0.039577063,-0.025184203,0.022623463,-0.022930048,-0.0951553,-0.057673667,-0.08306889,-0.029566238,6.3389285e-05,0.004427722,0.04538132,-0.0040916726,0.011727074,-0.065827265,0.0103221685,0.015675515,0.0438261,-0.040524445,-0.0006350434,0.0054974705,-0.047671556,0.052400168,0.033403225,0.04142113,-0.072672695,-0.009333982,0.033999115,-0.02571403,0.04170239,-0.03283845,0.046344433,-0.061005235,0.008733725,-0.12741867,-0.032518245,0.003142277,-0.077314354,0.04357436,-0.015142481,-0.045311872,0.027157156,-0.10186155,0.010079778,0.08296188,0.08365287,0.013410321,-0.021482801,-0.009870852,0.026188225,0.104507156,0.16029288,0.019660478,-0.010272161,-0.0014842529,0.025568888,0.004322879,0.0034471848,0.10201702,0.035587516,-0.010081737,0.023579367,0.0048519974,0.09184682,0.05110011,-0.109122366,-0.033370294,-0.042952348,0.018555123,-0.05513755,0.04534193,-0.030819857,-0.013364398,0.028256211,0.026210712,0.023530465,0.017010564,-0.1035388,0.011553542,0.10142673,-0.033724803,-0.048187595,-0.018725926,-0.023761734,0.036301907,0.011257716,0.07156674,-0.017759176,-0.0030565967,-0.066561535,3.3758393e-34,0.041200876,0.02007743,-0.024799576,-0.021744156,0.0069516413,-0.0011524584,-0.0624146,0.028224427,0.009502094,-0.11775178,-0.06235957,-0.083838105,0.016837176,-0.049897112,0.06422108,0.010747974,-0.020088281,-0.001342595,0.04421239,-0.044814862,-0.11280726,0.006203281,-0.039978955,-0.0067276442,-0.079261355,0.045455184,0.068835266,-0.014110036,-0.015028295,-0.03763559,-0.0062375152,-0.075137265,-0.043534543,0.009423583,0.020907717,-0.01050658,-0.05834547,0.012391595,-0.032834344,0.04029167,-0.012172262,0.07548837,0.06910577,0.034381468,0.009542826,0.01775343,-0.05712855,0.08417291,0.051071845,0.06904644,0.008141454,0.028049104,0.11723968,0.008956402,-0.05094261,0.11241012,0.025089014,-0.0043768315,-0.022216322,0.056590233,-0.028977402,-0.0027236778,0.01636195,0.06769713,-0.025979994,-0.07508887,-0.09972068,-0.060663763,-0.010404592,0.11552213,-0.06140783,-0.004908159,0.043224383,0.06567635,0.013564399,-0.013560545,0.037854142,-0.047132775,-0.04472257,-0.0061602313,0.012806554,0.00068945927,0.021642346,-0.019183453,-0.06850994,-0.016265163,-0.07144357,-0.05664689,0.006956047,0.023752227,0.035281297,-0.033296075,-0.093202606,0.054549806,-0.043238796,-1.9143184e-33,0.06250864,-0.024651336,0.034445398,-0.084603064,-0.04899692,-9.7593955e-05,-0.020173755,0.031956844,-0.0052513424,0.035961274,0.05560563,0.04042634,0.098866895,0.015607813,0.018169377,-0.03315501,0.06805321,0.12954511,0.013645566,0.052714814,-0.031079808,0.07637351,-0.095593214,0.018532837,0.023956683,-0.01827437,-0.0307039,0.060202006,-0.003107364,0.047954883,0.13776213,-0.026804682,-0.03708061,0.005023761,0.11019235,0.056226585,0.08249038,-0.020431148,0.013478687,0.06654161,-0.05455636,0.07202627,0.033950362,0.034981363,0.05354986,0.015655285,-0.062071774,0.0026680876,-0.07257511,-0.055511814,0.040436216,-0.009298259,0.04809442,-0.0002968439,0.028474856,-0.01802714,0.01610665,-0.019214017,-0.008433451,-0.056180816,0.003474984,-0.013471579,0.005954492,-0.049805593,-0.056108095,0.014080586,-0.06682277,0.011141377,0.03082804,-0.019863449,0.02320613,0.0054815384,-0.0061009172,0.060281757,-0.048458144,-0.06878167,0.008279612,-0.10377573,-0.03415317,-0.08111492,0.06184646,0.05349339,0.05166897,-0.06400222,-0.031218339,0.014705541,0.077650264,0.17389174,-0.02197498,-0.023479015,0.049009133,-0.058888324,-0.10096979,0.098332115,0.09578542,-2.978558e-08,0.002488735,-0.07511568,-0.02984445,-0.032479532,-0.064628735,0.012271851,0.007551541,-0.011189106,0.07293396,-0.07448877,-0.04444462,0.016494116,-0.07764704,0.09314834,-0.04329327,0.025730416,-0.040119488,0.033554327,-0.040650293,-0.01121014,-0.05369727,0.05867758,-0.0517785,0.003176318,-0.028579876,-0.043030955,0.019440753,0.018053861,0.030401628,-0.053410083,0.05456826,0.06179964,-0.030872853,-0.021805057,-0.07836817,0.04367708,0.020146279,-0.0061667566,0.04991925,0.040733363,0.024569523,0.0031892725,-0.0315439,0.018507592,0.055843253,-0.041488446,-0.010594754,0.03924283,0.01562508,0.0021827326,0.06964185,0.016511839,0.023911744,-0.060227346,-0.06587761,-0.09937817,-0.09127415,-0.06279252,0.0049712076,-0.08527107,0.043581787,-0.023607085,0.15094288,-0.047117807 +2.1.1.341,"The enzyme, characterized from the bacterium Sphingomonas sp. SYK6, is involved in the degradation of lignin. The enzyme has similar activities with vanillate and 3-O-methylgallate.",384,1.0,-0.01919239,-0.08608238,-0.058881376,-0.006159751,0.11300744,0.023122305,0.0057088216,0.009989195,0.01089512,-0.0030254105,0.054193508,-0.0136495,-0.13889897,0.01945654,-0.04833493,0.10307132,-0.082079515,0.009273943,-0.021477684,0.051141135,0.066088,-0.0025845652,-0.038091652,0.079977475,0.025733769,-0.05008249,0.06405322,-0.040254585,9.0745525e-05,-0.061063655,0.023418196,0.04119319,0.0365603,-0.029258898,0.06546919,0.15129703,-0.029471615,-0.027371919,0.040671162,-0.06677072,0.015567164,-0.046508804,-0.008989302,-0.06468988,-0.052846085,0.066966064,-0.008899068,-0.022960063,-0.034083113,-0.03150471,-0.01224111,-0.09374686,-0.023176368,-0.011040085,0.016819948,0.0061779367,-0.0525891,0.052673634,-0.015040836,0.077275544,0.008171052,0.052410066,-0.030301796,0.002822737,0.020445384,-0.0321411,0.076441534,-0.09256321,-0.028064948,-0.00626451,-0.040466398,-0.072877765,-0.014508573,0.01109539,0.0073241987,0.041762374,0.020433389,-0.052628793,0.0008763995,-0.118408464,0.040036917,0.05223085,-0.0073058563,0.05034769,-0.069848344,-0.054208662,-0.0026199985,0.035437115,0.052594833,0.014977202,0.03483345,0.06940473,-0.036410753,-0.060546774,-0.01459272,0.1302107,0.04153782,0.07728193,0.040536568,0.035038073,-0.040875316,0.10558678,-0.011866979,-0.14988875,-0.03442169,0.019871162,-0.043922517,0.035300754,0.07074303,0.0562909,0.037500404,0.06895921,0.048529223,-0.007873732,-0.012662233,0.054835908,0.05955892,-0.058316264,-0.07001725,0.042408187,-0.012694943,0.016553458,0.043866385,0.08250443,-0.017666984,0.012579824,-0.021924939,-2.1964746e-33,0.025031136,-0.055623423,-0.025111137,-0.054527026,0.0010522585,-0.07636373,-0.022299994,-0.03489852,-0.06399922,-0.0046603223,-0.026720516,-0.08096569,-0.051047686,0.0073427465,0.004451408,0.059288327,-0.021011157,0.0021033958,0.025882857,0.02292407,-0.007574219,0.0222664,-0.1058522,0.022064518,0.016564809,0.0757384,0.06688845,-0.008066485,-0.022096924,-0.0647965,0.14337109,-0.025074644,-0.12664303,0.03438837,0.07064951,-0.013157941,-0.01787279,0.019422876,-0.020360392,0.0070719817,0.035907306,0.04499566,-0.009677422,0.026718348,0.009305705,-0.0038845614,-0.06344144,0.07554361,0.028337155,0.008047497,0.03298783,-0.024342345,0.023213813,0.055779684,-0.015109032,0.0059396545,-0.00049728603,-0.05061305,0.037512172,-0.04048977,0.06565849,0.02096137,-0.054902356,0.04391106,0.023737896,-0.050252248,-0.07247586,-0.012148636,0.049328897,-0.028176246,-0.0730251,-0.035523843,-0.01766477,-0.0055411393,-0.081969105,-0.04569217,-0.066649415,-0.029326318,0.006165416,0.05894443,-0.028889064,-0.0064311973,0.020396339,-0.07411038,-0.087177575,0.021573314,-0.05153337,-0.029237436,-0.052914098,-0.06491374,-0.0034567814,-0.06491665,-0.08313316,0.01875278,-0.032931425,-1.9716044e-35,0.052126616,-0.029855432,0.040395595,0.005817973,-0.042487033,0.038624074,0.008292274,0.051866513,-0.054605667,-0.0768214,0.037702013,0.014392266,0.035319347,0.00242652,0.062771134,0.087456346,-0.025318503,0.025290262,-0.023596475,0.0004043577,-0.007150775,0.14534684,-0.09229345,0.049604587,0.0195083,0.0084075695,-0.047535367,0.10974254,0.0402097,0.043173585,0.024615234,-0.011681587,0.051625583,-0.0131430365,-0.012460588,-0.06599622,-0.044208597,-0.04327815,-0.01829206,0.019751657,0.00746447,0.017257323,0.0038097922,0.017374828,0.01266175,0.08062663,-0.10015502,-0.0010332018,0.026764307,0.0054888055,0.061315343,-0.015003789,-0.037667207,-0.01235942,0.010106086,0.034387365,-0.017092591,0.017832503,-0.072258666,-0.034990203,-0.024248997,0.0064156726,0.0618796,0.03426733,0.014005195,0.1438277,-0.016598707,0.04456427,-0.0006493307,-0.050054174,0.0810741,0.056574848,0.0032601438,0.017665537,-0.02955624,-0.046838712,-0.03729422,0.06025994,-0.013604118,-0.023142772,0.048184127,0.033117723,0.030924402,0.026626915,-0.0026374878,-0.026834384,0.031192392,0.060649257,0.007000165,-0.02507226,-0.019292332,-0.028813256,-0.072666004,0.07871266,0.006438274,-3.0546307e-08,-0.04327949,-0.022366412,0.02852892,-0.045849804,0.001749631,-0.019751478,0.106881514,0.10515609,-0.04667125,-0.011214732,-0.07422098,0.03476418,-0.06474372,0.048138764,0.07233081,-0.03909874,-0.019771472,0.061401054,-0.080257624,-0.046046346,-0.013758059,-0.021446327,-0.049807835,0.07370239,0.0018314164,-0.006541259,0.002763731,0.0694488,0.039383244,-0.00944814,-0.00012715647,0.08216076,0.03130484,0.010723318,-0.036114957,0.0972408,-0.072253756,-0.07476922,-0.0504026,0.08349693,-0.02183147,-0.03253108,-0.03891062,-0.052483562,-0.05267182,-0.073652,0.0208027,-0.020419287,0.026353605,0.123980425,0.07530573,0.025319492,-0.07043309,-0.01932588,-0.091942385,-0.04096211,0.0034264883,-0.00083320733,-0.030533798,-0.08022122,0.07220524,-0.044713747,0.16781712,-0.06413735 +2.1.1.342,"The enzyme, studied from the bacterium Escherichia coli O157:H7, is a radical SAM (AdoMet) enzyme that is involved in heme degradation and iron utilization under anaerobic conditions. The enzyme uses two SAM molecules for the reaction. The first molecule is used to generate a 5'-deoxyadenosyl radical, which abstracts a hydrogen atom from the methyl group of the second SAM molecule. The newly formed methylene radical attacks the substrate, causing a rearrangement of the porphyrin ring that results in the liberation of iron.",384,1.0,-0.09725067,-0.020621974,-0.114182584,0.113175325,0.10080015,-0.023300495,-0.022005156,0.0099039115,0.01719657,-0.021742923,0.015633792,0.054838173,-0.121799275,0.05384656,-0.015621932,0.05794785,-0.07416068,0.039616276,-0.028772077,-0.025362227,0.0355368,0.045357745,-0.02033901,-0.00604188,0.04713124,-0.014749144,0.119962186,0.018044967,-0.06491578,-0.04433349,0.09100897,-0.008709205,0.08202897,-0.031201493,-0.0053106556,0.06988331,0.024978656,-0.11171047,0.010812642,0.0004715272,-0.024558457,0.044974715,-0.05417447,-0.055104755,-0.039844178,-0.061818026,0.03136077,-0.004954465,0.028638847,0.0042945277,-0.043363757,-0.013100886,-0.037547693,-0.02607036,-0.0013460113,-0.029610503,0.0043063364,-0.096252955,-0.015569769,-0.015552991,0.075269476,-0.008363939,-0.058352936,-0.04061822,-0.050885648,-0.07793685,0.11552189,-0.0728087,0.013363792,-0.08026482,-0.050413243,-0.011449456,-0.0506787,-0.010806763,-0.05834738,-0.0009807368,-0.0033467247,-0.09632436,0.11096893,-0.0068921368,0.01673744,-0.017954191,0.0014483373,0.09545623,0.047399074,0.08839465,0.008056798,0.01009711,-0.015657797,0.03710377,-0.032250687,0.046194565,-0.00472306,-0.07673939,-0.017541282,0.0113114575,0.006221911,0.050737403,-0.04087223,0.019091586,-0.05024498,0.13418491,-0.029108774,-0.094033234,0.012736984,-0.044021975,-0.01042886,0.1520845,0.103290014,-0.0038120362,0.03407506,0.032871917,0.069075115,-0.0027438754,0.003999301,0.0901582,0.019846836,-0.030585844,-0.07930634,0.058848865,0.016288165,-0.011548597,-0.012059972,0.035987735,-0.04464587,-0.025480129,-0.071595214,1.8245603e-33,0.109455355,0.030296214,0.045036703,0.010126179,-0.024861004,-0.041377634,-0.10899319,-0.046889193,0.056458015,-0.013935901,-0.059204563,-0.1313791,0.0625087,-0.05286496,-0.028479205,-0.09022232,-0.027395159,-0.0036470937,0.032466188,0.055734254,-0.039974067,0.08796317,-0.049863435,-0.013397216,0.0038496898,0.09641622,-4.321394e-05,0.0055847256,0.034107354,0.024891581,0.01038589,-0.045088552,-0.12809005,0.016764322,0.0794447,-0.00072687183,-0.012190387,-0.0025736645,-0.0060707116,0.013455474,0.05753974,0.03143678,0.023156386,0.04720798,0.069553286,-0.007383068,-0.050728664,0.098608434,0.06254565,0.10329802,-0.0065914006,0.020350842,0.09566211,-0.024473654,-0.029072681,-0.02068787,0.005523195,0.030568575,0.056067456,0.0931395,0.038834587,-0.00038914278,-0.045883946,0.10518523,0.018278202,-0.016271014,-0.024681084,-0.03388703,-0.017478934,0.10805875,-0.028367475,0.028020225,0.076957874,0.031279277,-0.058497008,-0.04736133,0.014289533,0.027961548,0.07668824,-0.04170604,-0.034398597,-0.037657537,0.007475922,-0.056258794,-0.07686374,0.011804577,-0.046896335,-0.0233117,0.01733406,-0.022633607,0.033511065,-0.09556891,-0.042634692,-0.023395782,-0.014191854,-2.4568831e-33,0.029096754,-0.06888474,-0.021763906,-0.08114025,-0.08197579,0.07254889,-0.034605276,0.028351784,-0.07132809,-0.037061665,0.083858795,-0.037444368,-0.0053033372,-0.049884595,0.058210734,0.02882871,0.024601521,-0.022160996,-0.03394542,0.027161283,-0.04010464,0.047976058,0.026008578,-0.028302375,0.096528545,0.00022972483,-0.004493152,-0.0010952954,0.071154386,0.043573093,0.07028772,-0.046565186,-0.034057256,-0.02223561,-0.03889102,0.051997725,0.027203584,0.009294235,0.004244013,-0.031814396,-0.016662957,-0.06694366,0.02843398,0.1494932,0.023617735,0.06881103,-0.07490508,-0.02166871,-0.012064716,-0.058845412,0.01445163,-0.008304263,-0.01688059,-0.044960827,-0.03611775,-0.007524224,0.046080127,-0.003236823,-0.073305294,-0.0012118331,-0.003953727,0.012578541,0.09174697,0.039601143,-0.014229606,0.037155554,0.008346763,0.052363202,-0.0016229086,-0.06349128,-0.0070202304,0.019783542,0.027904471,0.05902412,0.021877022,-0.04881753,-0.03281049,-0.0016268461,-0.015864536,0.02675391,-0.030231308,-0.025678786,-0.08793981,-0.04662185,0.022453569,-0.08502675,0.039192747,0.093970865,-0.012088841,-0.023922613,-0.058408596,-0.015887408,-0.077901825,0.046226885,0.0017017497,-3.749279e-08,-0.033158034,-0.09155741,0.04911699,-0.0539562,0.0024264709,0.08273916,0.00784662,0.01743017,-0.0032001014,-0.0081545105,-0.02485904,0.15435699,-0.015570603,-0.008783813,-0.016653357,-0.030369462,-0.020583058,0.02098546,0.0015036733,-0.04144521,-0.013434052,0.01753751,-0.024091482,0.01954942,-0.0074588223,-0.034315884,0.015497378,0.059784856,0.01545314,-0.026308332,0.0034614953,0.047162805,-0.0106396,0.029765597,-0.1170602,-0.009108542,0.009600423,0.02017551,-0.039998766,0.07527314,-0.024691869,-0.0076042325,-0.12802401,0.02461964,0.021058438,0.029037593,-0.016762387,0.012399081,2.8628081e-05,0.009144115,0.042781126,-0.019911397,0.029091757,0.00887529,-0.10192892,0.03875483,0.012293846,-0.0815971,0.016767558,0.009852991,0.03756474,-0.0032459795,0.085008845,0.023329092 +2.3.1.264,"The enzyme is found in some methanogenic archaea and bacteria. In archaea it is induced under salt stress. The product, N6-acetyl-beta-L-lysine, serves as a compatible solute, conferring high salt resistance on the producing organisms.",384,1.0,-0.0880204,-0.08247591,-0.06863549,-0.001554641,0.12894736,0.055081107,-0.06416639,0.0051796776,0.02904085,-0.03728774,-0.011492145,-0.022927895,-0.019379346,-0.0034938583,-0.097549394,0.0444131,-0.05300209,-0.02666876,-0.013299389,-0.047326017,0.10928838,0.12172249,-0.028222533,-0.02476297,0.0064859777,-0.021651182,0.0833629,-0.047559507,0.002936972,-0.07120377,0.022198511,-0.033855997,0.068729594,0.0018165444,0.0383232,0.13775507,-0.030170407,-0.04351921,0.080655664,0.01692949,-0.031814344,0.00018809592,0.03767119,0.0049132914,0.0029933362,0.007378183,0.026535712,-0.017346218,0.0880602,-0.018753322,-0.0508677,-0.04249507,-0.0006321433,-0.025068264,0.0002527181,0.037657984,-0.10776085,-0.06069924,0.014346844,-0.0006655285,0.10616829,0.09273353,0.050802544,-0.021143043,0.06625862,-0.05362521,0.06079239,-0.028198898,0.074737,-0.088052206,-0.027288182,-0.008127976,-0.017854907,0.012423986,-0.01821262,-0.016687332,0.0012053974,-0.060710393,0.05314217,-0.01382365,0.016273225,0.0021803943,0.03856894,0.067065425,0.06143709,-0.06875862,0.028369071,0.007486909,0.06707872,-0.05657315,0.03621826,-0.06844464,-0.05461344,-0.057449076,-0.06440428,0.0024087385,0.009413932,0.010818884,-0.03856629,0.008848588,-0.006702058,0.028341604,-0.02712866,-0.062152456,-0.017308282,-0.01433531,0.05522241,0.07914598,-0.012203717,0.08554817,0.029677475,0.039325263,0.049126424,0.0023107885,-0.0029888777,0.055532333,0.0027068723,-0.085515566,-0.09631082,-0.00043357632,0.026980363,-0.024553716,0.037840966,0.0976525,-0.018884175,0.14439146,-0.09753345,3.4479848e-34,0.069757804,-0.010063124,0.0055912277,-0.04108546,-0.018169882,-0.037225526,-0.05120557,0.008416253,-0.016634611,-0.061822906,-0.052158296,-0.00635134,0.08434622,0.0062357765,-0.040191565,0.0059721246,-0.003672102,-0.052750595,0.0738355,0.035220172,-0.07017417,0.0101327235,0.018533193,0.028597789,-0.047879208,0.005391868,0.0452542,-0.026853636,0.08237018,0.0038814477,0.00124918,-0.10294094,-0.056676146,0.031119637,0.061951272,0.07780434,-0.07774918,-0.025124723,-0.024963835,0.028590623,0.025002206,0.06862482,0.024134573,-0.0074130916,0.052010063,-0.015319177,-0.0895736,0.08962869,-0.018930834,0.02055134,0.040564187,-0.028476873,0.058604185,-0.013846945,-0.01713625,0.012268862,-0.027215378,-0.019621184,0.031626496,0.10050467,-0.020404385,0.023208281,-0.008584242,0.076793954,0.0071814787,0.030454047,-0.011870192,-0.035582546,0.020984802,0.035988845,-0.06840361,-0.035847314,0.017868355,0.097171135,-0.050254162,-0.07339021,-0.049903788,0.0027865756,0.03150849,-0.058548875,0.020447379,-0.07586777,-0.010965154,0.03435915,-0.06701318,0.002969911,-0.027443573,-0.05570372,0.0043891408,-0.0051633934,0.049468752,-0.035660915,-0.035335213,0.03686019,0.006708304,-1.7173868e-33,0.06175913,-0.13849117,-0.0036792613,-0.042536605,-0.033043012,0.051592335,0.006841465,-0.07725374,-0.009921738,-0.039463535,0.06163763,-0.03639461,0.037379496,-0.043746375,0.0546166,-0.013480077,0.0012056777,0.0899796,0.023850508,-0.0039930907,0.031573366,0.053265095,0.011705064,-0.0018279703,0.0485909,-0.002813465,-0.04471532,0.053136986,0.0058147404,0.014191731,0.013148668,0.028075073,-0.05561004,-0.08768466,-0.06544196,0.052230977,-0.04157916,-0.06593653,-0.014220328,-0.009600355,0.0436505,0.07624093,-0.0060086087,0.06846805,0.0423641,0.08027037,-0.033279613,-0.06744178,0.028133342,-0.08421574,0.05962278,-0.12134435,0.025877,-0.03092232,0.017000513,0.061907336,-0.054312475,0.09079693,-0.030479401,0.011004156,-0.016766472,-0.04903172,-0.0015873576,-0.046608213,0.04024515,-0.0088643795,-0.017012447,0.09138729,-0.017502785,-0.024281932,0.057358023,0.014493293,0.08950574,0.074039824,-0.056847777,-0.024295902,-0.085953034,-0.03334678,0.026370067,-0.06088278,-0.03472372,0.04280184,-0.027286382,-0.0072410125,-0.07528144,-0.045958433,0.09164879,0.07227256,-0.0015189947,0.027016537,-0.0731,-0.05336481,-0.13805073,-0.005383118,0.09215012,-3.419958e-08,0.10428894,-0.046268836,0.04587587,-0.072726615,-0.013475594,0.09187916,0.092107214,0.045508295,0.01945844,-0.012365323,-0.021688417,0.1006901,0.023611886,-0.008839655,-0.022935968,0.059287895,0.0006391161,0.04226551,-0.067961976,-0.0045939153,0.0005263895,0.014689618,0.0053142216,0.022707175,-0.018898606,-0.076284625,0.0562759,0.047404606,-0.029707469,-0.09357906,-0.054136872,0.0016946867,0.027185023,-0.10157259,-0.047000345,0.07403572,-0.049005043,-0.022523979,0.021893404,0.024327923,-0.07381039,0.028233523,-0.07545222,-0.015395661,0.017920915,0.038728327,-0.023509996,0.06686109,-0.045680385,0.016889006,0.007413593,0.0018618008,0.01723309,-0.049094576,-0.08108957,-0.008087119,-0.05621271,-0.060870357,0.011694003,-0.04181498,0.007948464,0.0028327047,0.12335016,0.0002891059 +2.3.3.19,"The enzyme, isolated from several Streptomyces species, participate in the biosynthesis of certain phosphonate antibiotics. The enzyme is analogous to EC 2.3.3.1 (Si)-citrate synthase.",384,1.0,-0.0677002,-0.013459857,-0.12718493,-0.04204421,0.008476272,0.040478073,-0.06845671,0.072137035,0.081204854,-0.049699597,-0.011025797,-0.084225446,0.012117974,0.03241021,-0.05537483,-0.059755698,-0.08680375,-0.02293064,0.015339496,-0.050752725,0.082889274,0.080963045,0.018265238,0.0061962786,0.075649835,0.043543674,0.009567121,-0.02521562,-0.004697363,-0.039986044,0.038598835,-0.026284028,0.11817768,-0.11491527,0.08851063,0.08114276,-0.061266214,-0.10518198,0.08712705,0.026971562,0.024522629,0.03472177,0.0073077097,0.03429815,-0.046586208,0.029562743,0.01914692,0.06877036,-0.012292506,-0.03268369,-0.032427926,-0.0870855,-0.04882033,0.068448246,0.008394239,0.065940425,-0.015624465,0.045701317,-0.025138333,-0.03618819,0.10552344,0.009595919,0.0333277,0.031064525,-0.047411278,0.0001928837,0.06789495,-0.10470327,0.035456467,-0.04493276,-0.111930504,-0.053235486,0.032234665,0.051739357,0.043314118,0.04722325,0.030774262,0.0022705155,-0.048911937,-0.0061629433,0.046143927,-0.031576235,-0.059996814,0.013682683,0.057172377,-0.019848084,0.0074101156,0.023370808,0.033989012,0.0018887513,0.019930532,-0.023114098,-0.013755566,-0.060458295,-0.03728791,0.05490365,-0.08448158,0.07023956,0.05394934,-0.03093046,-0.012269533,0.0841434,0.0042388523,-0.04569157,0.00019178182,0.004335084,-0.03192344,0.019752212,-0.0036543603,-0.021644378,-0.014029697,-0.014056568,0.03118727,-0.007408521,0.037934214,0.06615376,0.082341336,-0.08718423,0.0067467573,0.02725319,0.048794035,-0.050031774,0.0051176464,-0.011412471,-0.023085143,0.055901766,-0.13059652,-6.6489267e-35,0.0077087176,0.069154374,0.05655726,-0.08945004,0.04343923,-0.02939188,-0.08655146,0.0062732175,-0.08113227,-0.095453665,-0.069305144,-0.06759533,0.038010128,0.028961197,0.038120955,0.002851691,0.04692801,0.05509206,0.034162834,-0.027917746,0.08022404,0.013380996,-0.055220995,0.050916795,0.07066875,0.069934234,-0.025461195,0.010949435,0.07576758,-0.038143307,-0.017977497,-0.07954578,-0.06754994,-0.015328697,0.022256142,-0.052487932,-0.082228445,-0.06314753,0.041644797,0.06929889,-0.010182147,0.018907353,0.036113568,0.02244574,0.08020034,-0.03818296,-0.09185763,0.055060256,0.11504631,0.018350633,0.022794861,-0.042766653,0.058215488,0.0047552465,-0.028362902,0.035819486,0.007987343,0.028854702,0.03524284,0.0028344793,-0.020362638,0.05071878,-0.011860566,0.038938984,0.038193215,0.027270317,-0.0615978,-0.007915972,-0.00689548,0.049776696,-0.106560834,-0.03225817,-0.030579781,0.002845728,0.014482949,-0.037848193,-0.09225495,-0.046834037,0.06734242,0.023944642,-0.028434066,-0.0048164823,-0.02486805,-0.033301163,-0.071025535,-0.048287373,-0.031795643,-0.04123124,0.027526101,0.04801354,-0.026815785,-0.061927225,-0.10298519,0.03237344,-0.027949791,-2.2434508e-33,0.10261673,-0.031139415,0.07828098,-0.06473,-0.06746838,0.110245734,-0.027755564,0.0028535211,0.038953524,-0.00021408372,0.04859609,-0.049043316,0.048584584,-0.05028796,-0.0034960846,0.0069572143,0.034609716,0.08172435,0.0192378,0.041523717,0.10183829,0.016614018,0.015147437,0.030574333,0.021287676,-0.032935593,0.0006486248,0.07402257,0.021975517,0.047156025,-0.038515948,-0.06868915,-0.048726723,-0.08553261,-0.06618952,0.0724641,-0.038267963,0.0072793714,0.074933976,0.0022851678,0.075414374,0.036545236,0.06730129,0.052934777,0.026412005,0.06285469,-0.045232058,0.060806558,-0.028272957,-0.06661993,0.019764993,0.047060467,0.010879424,0.019882077,0.015916863,0.0054301047,-0.017913895,0.0075209406,-0.054908305,-0.0503701,-0.02354575,-0.08076121,-0.000968568,-0.021101732,0.04147173,-0.012785863,-0.04445806,0.0702371,0.067550495,-0.010385677,0.050036673,-0.018033775,-0.04619334,0.008774826,-0.05693549,-0.03864621,-0.11552713,-0.038870733,0.045183998,-0.022974132,0.032706216,-0.012802152,0.050591104,-0.058481507,-0.012313262,-0.050266623,0.05799502,0.020481303,0.034534413,0.04582826,-0.070667475,0.020274827,-0.061740946,0.033316366,0.057623576,-3.0879367e-08,0.0761013,0.0006848148,0.0743878,-0.027448392,0.020810353,-0.031809986,-0.035277657,-0.06810111,-0.00089068897,0.043125346,-0.044227198,-0.068346314,0.020740956,-0.050943963,0.035248674,0.07091334,-0.05142417,0.016914077,0.007734441,-0.0032830774,-0.028887957,-0.011043032,-0.063542046,0.045129687,0.046526086,0.0026756043,0.034864224,0.018804291,-0.05006495,0.05420176,-0.0027477674,0.01564469,-0.011572021,-0.011566446,-0.08867632,-0.03571879,-0.059408486,-0.05290968,-0.024292784,-0.004761782,0.027035119,-0.015169513,-0.08805365,0.045088287,-0.04096416,0.031424724,0.008396151,-0.031676546,-0.051090926,-0.09551973,0.094425045,-0.028603757,-0.012026604,-0.014732394,-0.08447637,0.035930865,-0.0018089393,-0.037937555,-0.05055064,-0.037120927,0.0024253463,-0.01792585,0.20660919,-0.011050534 +2.4.1.346,"Requires Mg2+. The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). 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+2.5.1.140,"The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.",384,0.99999994,-0.076858595,-0.04406818,-0.14846584,-0.014551054,0.027515193,0.04062114,-0.097033896,0.030771103,0.051325977,-0.027261762,0.04257783,-0.07240141,-0.081525,0.026229255,-0.03632533,0.022717847,-0.123899385,-0.025334897,0.012128984,-0.012469962,-0.025904307,0.09200902,-0.03561827,0.012998368,0.017426891,0.009585468,0.027764978,0.004030493,-0.023336772,-0.013342912,0.00935103,-0.033000454,-0.00049629365,-0.021644417,0.020038405,0.096443206,-0.028538337,-0.0646592,0.05061092,-0.015093308,-0.02517881,-0.027321825,-0.020110697,-0.033950593,-0.050058883,0.021418782,0.03336973,0.04543837,0.041345023,0.011274749,0.029269084,0.014109281,-0.0737183,-0.017357478,0.004116152,0.022384306,-0.06316322,-0.029206026,-0.003708391,0.01743206,0.0313133,-0.018445175,0.034029048,0.015374857,0.01286004,-0.07061834,0.02400499,-0.07671951,0.033206042,0.020971801,-0.06860277,-0.073094405,0.0061674085,-0.008048583,-0.017376628,0.060155824,0.012741505,0.00092549395,0.016682204,-0.044477027,0.039665252,-0.0026141661,-0.020089101,0.16675237,0.024408735,0.029893033,0.0382494,0.0023068932,0.019066252,0.060685944,0.037413552,-0.03623728,0.0048862784,-0.09420976,-0.060701102,-0.0033649877,-0.0655983,-0.0021130492,0.0027137874,-0.036633283,-0.065798916,0.03432491,0.021790186,-0.06302185,0.024653813,-0.05974364,-0.0117956,0.06342745,0.06668284,-0.028035758,0.048746657,0.0832927,-0.037558455,-0.0030144893,0.035323013,0.08056044,0.058737285,-0.08686994,-0.081454426,-0.024333376,-0.019558199,-0.056196537,-0.014022286,0.04394561,-0.07590965,-0.027252872,-0.087153666,4.038819e-34,-0.0058992165,0.007944087,0.053617954,-0.0658718,0.023992356,-0.040204953,-0.070829846,0.026895802,-0.012394158,-0.05377615,-0.05258952,-0.054394007,0.04937922,-0.0033554737,0.052790433,-0.08612988,0.0006518191,0.015646616,0.035684213,-0.06948116,0.01733254,0.064531095,-0.03326312,-0.012932494,0.007572779,0.032155268,-0.0055375723,0.06058365,0.09119642,-0.025587877,0.026729802,-0.06451023,-0.042697277,-0.037678234,0.12205065,0.016896699,-0.01412116,-0.015559364,0.037711613,0.015209923,0.013815262,0.0076284683,0.008706029,0.031657323,0.051821474,-0.0354806,-0.047098596,0.06859273,0.039582543,0.006132508,0.014183654,-0.03980384,0.11507117,-0.0334203,0.007191199,0.042979013,-0.00059007946,0.023707718,-0.012834786,0.10224806,0.021196045,0.033763416,-0.05525326,0.022304444,-0.009475469,0.040824816,0.07674415,-0.058797732,-0.0017991284,-0.015602839,-0.026583662,-0.008796233,0.050007157,-0.00036239615,-0.011884101,0.03226959,-0.024144826,0.020118061,0.052175626,-0.047135428,-0.052770212,0.0317244,-0.0016737916,-0.07634136,-0.091070555,-0.016276045,-0.035408728,-0.05942932,-0.0068584434,0.024737565,0.035810646,-0.09613067,-0.037931483,0.024952918,-0.05150428,-3.227319e-33,0.0012124055,-0.18474562,0.03433104,-0.11103902,-0.05421206,0.12954497,0.062565126,-0.027241407,-0.063821144,0.025565384,0.057863515,0.030109523,-0.031039543,-0.024526555,-0.024584172,0.017059535,0.009800716,0.07721343,0.03228794,0.028076237,-0.003665327,0.10433976,0.12297409,0.0076074116,0.039712053,0.058425535,0.045212753,0.070177294,0.015384574,-0.0033536213,-0.023187065,-0.05792448,-0.042273596,-0.031110967,-0.04825804,0.044380993,-0.0027346015,-0.0026383882,0.05505918,-0.05454211,0.038781717,-0.006076253,-0.022843082,0.07838672,0.038674865,0.054814313,-0.118215196,0.08823282,-0.042205207,-0.0806491,0.01282471,0.08393772,0.04574218,0.030349405,-0.01725726,0.04069953,0.04402962,-0.05396299,0.0037748262,0.0068661207,-0.049610473,-0.071181595,0.027081048,0.045753676,0.035026155,0.046007905,0.021345584,-0.014654699,0.022490878,-0.10029354,0.08592895,-0.009793421,-0.002739179,0.0369116,-0.048910853,-0.037183,-0.021056972,-0.10964092,0.007770762,-0.02327992,-0.029289503,0.00676491,-0.004947479,-0.007122607,-0.019017749,-0.08657701,0.08235033,0.07123968,0.006167807,0.008136531,0.031858962,0.04046319,-0.037374645,0.07098218,0.0873077,-2.8048182e-08,0.058953945,-0.04791834,0.14179254,-0.085477315,0.015642172,0.017978467,-0.029385917,-0.04763751,0.017372953,0.006643316,-0.08653439,0.0056053638,-0.041333128,-0.03152253,-0.022689806,0.028982572,-0.061096862,-0.016864512,0.012094666,-0.062710434,-0.050545376,-0.0011370349,-0.0584852,-0.02839119,0.047991384,-0.0420328,-0.022863852,0.06985307,-0.040228948,0.008368273,0.018733397,-0.0067238193,-0.037168622,0.015260413,-0.04551714,0.035033934,-0.033418316,-0.06876233,-0.04950895,0.100534305,-0.00751521,0.0392879,-0.051250983,0.035239775,-0.011207407,0.06269071,0.010902515,0.049958598,0.0022532,0.045323998,0.049961373,-0.045786783,0.024915962,-0.05512719,-0.16992119,-0.006121778,-0.026921572,-0.110574156,-0.03447149,0.091124706,0.035515208,0.090245716,0.13388273,0.071804956 +2.6.1.113,"A pyridoxal 5'-phosphate protein. The enzyme, studied in the bacterium Pseudomonas aeruginosa, participates in a putrescine degradation pathway. cf. EC 2.6.1.82, putrescine---2-oxoglutarate aminotransferase.",384,1.0,-0.053338654,-0.057415973,-0.04844205,-0.07694973,0.043000806,0.067328885,-0.059892263,0.06397183,0.071753114,0.02935449,0.026359035,0.04895759,-0.031115463,0.12427057,-0.056035634,0.042757828,-0.10175882,0.036074363,-0.0037495324,-0.026452553,0.10856291,0.10656763,-0.040700182,0.0035176747,0.0016177503,0.036776066,0.041537642,0.02843128,-0.018165497,-0.0043511135,-0.07079931,-0.06718063,-0.031690475,-0.113339715,0.06674196,0.10305948,-0.020948157,-0.007845113,0.08754885,-0.014353974,0.03967558,-0.038130157,-0.046777412,-0.025984872,-0.031259112,-0.0023466025,0.105632156,0.029994372,0.08445706,-0.028919622,-0.071597956,0.016764197,-0.024419611,-0.031487584,0.022644103,0.009284318,0.008806152,-0.038562965,-0.059380762,-0.050994072,0.0085074995,-0.045679152,0.025630517,0.021424802,0.014898433,-0.023613162,0.052389562,-0.037096277,-0.012089681,-0.02477517,-0.083920546,-0.058039658,0.11450685,0.040292997,-0.035013027,-0.006199665,-0.034881484,-0.015167377,0.0037768758,-0.011300391,0.053264566,-0.056816395,-0.026233148,0.0653508,-0.0045942306,-0.023437615,0.027863681,0.019693406,0.02681326,-0.022349326,-0.013220803,-0.00983874,-0.00028434242,-0.035447415,-0.02964593,0.015696479,-0.04610419,0.03416601,-0.015933696,-0.042151853,-0.0014933457,0.05529237,-0.00026804884,-0.061651506,-0.05311607,-0.016655145,-0.013275728,0.102662586,0.039186526,0.02625326,-0.018942371,0.02346824,-0.030328857,0.014945809,0.030640187,0.07294127,0.037111223,-0.031976268,-0.081815794,-0.007266791,-0.006431154,-0.03507766,0.035059232,0.12546429,-0.024684377,-0.011088827,-0.08491362,-6.569622e-34,0.03911529,0.045294788,0.032502465,0.018643068,0.016990576,-0.005459137,-0.07315639,-0.010832113,0.0028735655,-0.042580556,-0.023600366,-0.088433504,0.04332504,0.0018842524,-0.038484048,-0.014711434,-0.054667767,0.033227302,0.046914328,0.0010312278,0.049233075,0.0958178,-0.011943278,0.03241747,0.073344536,0.06833595,0.045967393,-0.016618386,-0.039803322,-0.011566306,0.017051337,-0.07496648,-0.15108025,-0.113111466,0.08048948,-0.08232353,-0.030787233,-0.006903574,0.05316587,0.043930154,0.018911708,-0.011493592,-0.039011627,0.036804996,0.083111085,-0.0712315,-0.021702264,0.14293022,-0.04199249,0.05253496,0.03832204,-0.10059262,0.049735256,0.023446167,-0.12712209,-0.048735823,-0.04164206,-0.0399413,0.012625749,0.053878576,0.087606296,-0.023786914,-0.030110516,-0.008644642,-0.018078566,-0.06405649,-0.0051912284,-0.039294317,0.05801381,0.091953635,-0.016122162,0.021174751,0.03756008,0.06002945,-0.013780513,-0.10529686,-0.09725901,0.07279508,0.021894261,0.050951432,0.0014913185,-0.038940046,-0.04673645,-0.049192313,-0.0591235,-0.0004173921,0.07378372,-0.10272166,-0.0136684785,-0.020905621,0.09576901,-0.12923226,-0.06731699,0.043232623,-0.019113753,-5.1960143e-34,0.060134996,-0.11780685,0.062477846,-0.030156968,-0.058310296,-0.029420754,0.036450867,0.10097828,0.019908352,-0.030100808,0.04333149,0.023975676,0.029672625,-0.021067517,0.03875407,0.015341355,-0.026161095,-0.037180874,0.027447874,-0.0039790706,0.0360224,-0.012513971,-0.017391164,0.035438925,0.07799824,0.10756391,-0.030926088,0.06496891,0.014794149,0.02103628,-0.0037070494,0.041086677,-0.04519242,-0.007141095,-0.06384075,0.011035176,-0.03597276,0.025174564,-0.014892135,0.001204964,0.08413685,0.09369746,-0.031385057,0.048758194,-0.054133214,0.041714534,-0.028466443,0.011285815,0.02905957,-0.10261736,0.058615472,0.00055436266,0.00021103788,0.0077111283,0.017008075,0.00060719927,-0.049203333,0.021477718,-0.049142767,0.0068946285,-0.011934453,-0.08802983,0.032862198,0.08258835,0.040963598,0.033908427,0.046909418,0.01500193,0.01020539,0.04948143,0.027600816,-0.03657643,0.04787629,0.047759455,-0.029140813,0.026707148,-0.083994806,0.012380829,0.0017244227,0.010809252,-0.05224008,-0.06547847,-0.06020789,-0.046568505,0.03036083,-0.057393745,0.082379855,0.14419074,-0.010440562,0.007951448,-0.0066551976,0.011933433,0.0007755578,0.04963729,0.019335033,-3.341643e-08,0.06168026,-0.051848233,0.052320104,0.0014023925,-0.0032636132,0.02681441,-0.0032851298,0.012823779,0.07836655,-0.02151532,-0.026548946,-0.0009986578,-0.02614888,-0.008720814,0.016898192,0.072429135,-0.055890676,0.01213955,0.0050676437,-0.059314035,-0.08410178,0.0068371147,-0.13012066,0.007835391,0.05074152,0.012382686,0.041978493,0.049391206,-0.01411791,-0.082961455,-0.0012001516,-0.036642358,0.018862853,-0.033943344,-0.06608817,0.0517363,0.0022524742,-0.024577737,-0.028666334,0.013019017,-0.04213917,-0.022076275,-0.03213453,-0.0122558605,0.064804554,0.0500715,-0.03221937,0.026878277,-0.03351565,-0.07712623,0.038911074,0.0120875,-0.05865714,-0.06387264,-0.15087913,0.022135215,-0.048744194,-0.013101776,0.0078004883,-0.004639984,-0.019257441,0.0003419725,0.118650444,-0.020415707 +2.7.1.217,"The enzyme, characterized from bacteria, is involved in D-erythronate and L-threonate catabolism.",384,1.0,-0.02257046,-0.08292509,-0.06997152,-0.016972253,-0.038203992,0.037104335,-0.044853706,0.07794461,0.0114790555,0.025838155,-0.013351725,-0.005075072,-0.0392101,0.05958224,-0.0066270665,0.020542841,-0.025687914,0.047631867,-0.03692219,-0.0139702745,0.05591456,0.07230874,0.016896082,-0.038702767,0.09113059,-0.0051032295,0.057533115,-0.023703007,-0.040819313,-0.051493105,-0.013385755,-0.07130246,0.102785885,-0.0075365677,0.06523807,0.04765652,-0.087894686,-0.03954096,0.05594567,-0.04481163,0.026490333,-0.0019104189,0.004579939,-0.022735177,-0.08459795,0.011731849,-0.021808809,0.009695524,-0.019269817,0.0035045245,-0.028553236,-0.06294034,-0.048607744,0.02278773,-0.04552856,-0.0077003567,0.04552571,-0.008000813,-0.059207834,-0.011754981,0.044319738,0.032356955,0.04939145,0.030418666,0.042319484,-0.043532457,0.052032255,-0.042292804,0.01557163,-0.035276853,-0.055365175,-0.09977155,-0.05041028,0.08556844,0.036591806,-0.037357956,0.058668748,-0.007447724,0.013867746,-0.024976196,0.06664032,0.06996924,0.012793463,0.11094009,-0.028399298,0.062968075,-0.0024024325,0.013146774,0.050303385,-0.032761786,0.03420086,-0.07607793,-0.08412863,-0.04187597,-0.093981974,-0.010432467,-0.0014996023,0.03333713,0.06700137,-0.046086498,-0.0024226469,0.06523879,-0.04195656,-0.06411519,-0.06804167,-0.041319218,0.0049623265,0.041679215,0.013129073,-0.085537404,0.07493223,0.009424817,0.06845837,0.056717765,-0.0083459,0.057328954,0.08375242,-0.07954607,-0.057054725,-0.016554948,0.002992507,-0.066639476,0.084614955,0.07426124,-0.047936242,-0.017658398,-0.100406654,-1.9048175e-33,0.061901566,-0.0051355558,-0.020305095,-0.051164497,0.046491597,-0.028581511,-0.07348798,0.019971268,-0.047689613,0.0011938824,-0.09598762,-0.066907726,0.065588966,0.015015838,-0.032227945,0.027630849,-0.022614285,0.038929477,0.022799252,-0.006701473,0.026290972,0.04449594,0.0013637497,0.05525031,-0.005843479,0.05856144,0.0127838245,0.088786714,0.049092818,-0.034078445,0.0041651335,-0.14383279,-0.046486914,0.04824965,0.010176036,-0.0019891532,-0.049728382,0.062909745,0.010517101,0.01754599,0.01711888,0.07816681,-0.025014907,-0.0015762358,0.06336712,-0.06152696,-0.024656493,0.09756403,0.057252914,0.05985859,0.06830169,-0.08199729,0.1274073,-0.09450857,-0.079726376,0.05161837,-0.018914502,0.01805363,0.0406207,0.06548816,0.023003947,0.058840837,-0.015509468,0.06098091,0.059408884,0.026470924,-0.01657326,-0.072943375,0.025697635,0.079906695,-0.063578255,-0.05447606,0.07507958,0.0021984589,0.035646114,-0.06433929,-0.06660282,0.0052624196,0.03611013,-0.0047354526,0.003668626,-0.008149226,-0.03809329,-0.0017988775,-0.062072027,-0.0029567662,-0.036528483,-0.07473049,-0.06877924,0.068316005,0.020431168,-0.023696164,-0.09634801,0.004419014,0.054312292,-4.8627713e-34,0.09260986,-0.054022737,-0.0144597255,-0.025091758,-0.017251974,0.080322705,0.003429939,0.06366538,-0.013839247,0.006936044,0.08711255,-0.0031632935,-0.026986526,-0.0042133406,-0.0067115747,0.025874201,-0.029084519,0.0227436,-0.029216668,0.01669738,-0.024383418,0.055637624,-0.011524488,-0.032231025,0.039571844,0.026003312,-0.024990333,0.052315943,0.03829829,-0.02207893,0.060351137,0.0050139152,5.8074165e-05,-0.07284433,-0.07761934,0.09565593,-0.04288054,-0.008089768,0.00088462286,-0.046274003,0.008583181,0.050118357,0.019077875,0.045756478,0.02308249,0.04041213,-0.10208592,-0.005422886,-0.02468568,-0.048337985,0.020274444,-0.0048441617,0.054528087,-0.0016479514,-0.008603875,0.083634965,0.04051202,0.017693374,-0.09225705,-0.0060089137,-0.05158337,-0.07710972,0.074353844,-0.013923011,0.01610417,0.02146822,-0.040635858,0.04714014,0.025580605,-0.038160887,0.095616914,0.01989852,-0.053137757,-0.023437412,-0.10297285,-0.060807414,-0.08173218,-0.02664564,0.027288536,-0.006072605,-0.021869322,0.0005676231,-0.04070404,-0.018401872,-0.036116857,-0.11205323,-0.04244702,0.113437,0.012094471,0.07387941,0.012269231,-0.04001033,-0.023505302,0.0165805,0.09048261,-2.968861e-08,0.050358962,-0.08136278,-0.021146145,-0.006766184,0.02489073,-0.006933862,-0.0105721755,0.04773977,-0.002892405,-0.0023536384,-0.040393665,0.059038594,-0.069232225,-0.007528556,0.050385226,0.05021999,-0.023486108,0.0070213974,-0.0538004,0.028030844,-0.024874583,-0.009122933,-0.12560144,-0.0025341085,0.034734145,-0.02320551,0.0010015724,0.01653454,-0.038911898,-0.034373254,-0.0021371131,0.01724083,-0.014271171,-0.061648495,-0.08758797,0.005033566,-0.060879022,-0.096801415,-0.0059772376,0.028156715,0.034507163,0.04863861,-0.06731806,0.060781837,-0.03330877,0.03530281,-0.015784262,-0.0055385884,-0.010880118,-0.034894794,0.007710941,-0.020040892,-0.017349841,-0.07280601,-0.15127808,0.12326429,0.021710062,-0.046397828,-0.0118480455,-0.013887741,0.1106543,0.057455495,0.18984312,-0.055492166 +2.8.1.15,"The enzyme, found in thermophilic bacteria and archaea, modifies the ribothymidine (5-methyluridine) residue at position 54 of tRNAs. Contains zinc and an [4Fe-4S] cluster. Some organisms, such as the archaeon Pyrococcus horikoshii, do not have a TtuB sulfur-carrier protein, and appear to use sulfide as the sulfur source.",384,0.99999994,-0.019917719,0.022137515,-0.11302567,-0.03414013,0.06635436,0.005745921,-0.062179342,0.016407225,0.01566021,-0.029274568,0.018782372,-0.027101014,-0.019368213,0.033193205,-0.068579614,-0.005267008,-0.055709444,0.016425306,0.04091641,-0.0483539,0.045797464,0.08756488,-0.004608447,-0.030754637,-0.0043545933,0.027834736,0.006702571,-0.013206908,-0.00422221,-0.012015402,-0.093071304,-0.007892999,0.033108603,-0.040246617,0.03410828,0.10628691,-0.05091417,-0.0045132576,0.075734034,0.020960364,0.06214678,0.049082886,0.01026696,-0.03942126,-0.057918947,-0.016847977,0.034735084,0.020547349,-0.005773402,-0.02223428,-0.04552766,-0.023653882,-0.012165114,0.070748806,-0.02047563,0.036758963,-0.04225933,-0.038170304,0.004996441,-0.08193335,0.07907964,0.013183166,-0.0030573125,-0.04937942,0.063278295,-0.0106967725,0.023858633,-0.03962072,0.039598778,-0.04225771,-0.036460772,0.03609879,-0.020351041,0.09430949,-0.06444221,0.09727457,0.0517394,-0.12287574,0.06768399,0.00540846,-0.028831992,-0.039209154,0.025250623,0.064324364,0.035729684,0.004749636,-0.031827405,0.031554945,-0.0022656068,0.017595017,0.058868833,0.019320898,0.010389332,-0.07566957,-0.106406875,0.032022342,-0.050012104,0.09249451,0.037239674,-0.020224111,0.016538298,0.027947878,-0.09238654,-0.07089124,-0.0380491,0.019333169,0.05164335,0.08124456,0.006606667,0.05143102,-0.028680747,0.011660523,0.029862424,-0.029457271,0.029473858,0.042840715,0.08628457,-0.042549625,-0.1331028,-0.02579745,-0.06054156,0.027734159,0.051869214,0.051116623,-0.034223713,0.01756476,-0.18121971,7.3183546e-34,0.06986774,0.059328455,0.09983384,-0.051327303,0.068667725,-0.00506248,-0.06059344,-0.014040252,0.026051445,-0.022871908,-0.12126533,-0.036309455,0.031977843,-0.059090048,-0.051728457,-0.02547802,-0.04369802,0.039357927,0.04702591,-0.0019279217,-0.00077335053,0.08068863,0.0065582525,-0.0061610537,0.047740467,0.042831555,0.0384376,-0.048593786,0.033087943,0.004054244,0.010541778,-0.09718709,-0.10641472,-0.03765945,0.16229106,-0.023044065,-0.03957511,0.024758523,-0.060395774,-0.03162439,0.018386846,-0.014498431,0.012831879,0.01715632,0.016594827,-0.07180647,-0.049038183,0.054042548,0.011396559,0.00079124275,0.009611516,-0.032947462,0.017547907,-0.028758118,-0.07551149,-0.01874391,0.019934757,-0.006553899,0.07955176,0.07611331,0.021041358,0.048294075,-0.048969142,0.06360784,-0.002203508,0.023237862,-0.041386105,-0.050957024,-0.015770826,0.10532564,-0.039093938,-0.05667,0.03572039,0.056532633,-0.025258759,-0.025226781,-0.082424596,-0.061163757,0.003051718,-0.037700947,-0.062024307,-0.13458052,-0.004014539,0.007928848,-0.0678579,-0.014918066,0.02221794,-0.047607504,0.03641139,0.037735783,0.0070019998,-0.055490527,-0.084112056,0.018437697,-0.041743364,-2.2751888e-33,0.065461375,-0.08781693,0.0075720088,-0.122122064,-0.07988214,0.040454596,0.044809043,-0.049758896,0.0039785584,-0.08118915,0.14644845,0.040911853,0.012367733,-0.05015642,0.047246464,0.023626313,0.059142243,0.054006033,0.03899651,-0.027852142,0.02591953,0.01954378,-0.02713376,0.04838635,0.036243785,0.021878902,0.054042198,0.036210082,0.0648196,0.028932303,-0.0023281786,0.054467708,0.012342564,-0.04178494,-0.0698342,0.002797272,-0.038160913,-0.03220993,0.06389992,-0.03231564,0.014565034,-0.019654192,-0.017627735,0.14633389,0.024745801,0.04196845,-0.054033868,-0.024395093,0.028605405,-0.023198007,0.12142299,-0.06118516,0.036643002,-0.006799523,0.07072065,0.03350744,-0.07127998,0.05144818,-0.01349339,0.006100138,-0.024532717,-0.047484726,-0.010628092,-0.024296021,0.021797083,0.017293794,-0.008243442,0.012005482,0.013896185,-0.022213664,0.020423992,0.051905256,0.026260562,0.006457253,-0.04732983,-0.016401764,-0.03338348,0.0532202,0.02849713,0.01949392,-0.065510094,0.06776597,0.007535697,-0.0503118,0.054646157,-0.08964976,0.035439465,0.1569753,-0.020491686,0.04778769,-0.06474189,0.013912325,-0.024474755,0.020109536,-0.042081434,-3.905146e-08,-0.02928177,-0.008323819,0.033006404,-0.005485876,-0.07074439,0.045937635,0.031987753,-0.015516953,0.02809964,-0.017119432,0.053255457,0.08587841,0.01035669,-0.0010754396,0.024614766,0.012878224,-0.12036692,-0.029181916,-0.020719554,-0.04775875,-0.05504718,0.022240534,-0.10254111,0.049325597,0.045862135,-0.012739262,0.013138347,-0.019140428,-0.01563604,-0.04023686,0.052955277,-0.011213743,0.0109659415,-0.04751002,-0.014183046,0.058991328,-0.05894589,-0.04913819,-0.023387,0.035162773,-0.028217964,0.028809885,-0.08142716,0.02841829,-0.030355573,-0.013139389,-0.03604571,0.08110509,-0.037085116,0.023004953,0.0615317,0.04151137,-0.0051251557,-0.059128024,-0.08118474,0.010267388,0.02435751,-0.10182908,-0.03629287,0.0059212274,0.07247747,-0.06598627,0.1317458,-0.014106098 +3.2.1.203,"The enzyme from the acidophilic bacterium Alicyclobacillus acidocaldarius is an endo-cleaving hydrolase that cleaves beta(1->4)-linked residues. However, it is specific for (carboxymethyl)cellulose and does not act on cellulosic substrates such as avicel.",384,1.0,0.007728029,-0.049431793,-0.10101815,0.028571064,0.013561047,0.03884108,0.008092879,-0.008051516,0.05032532,-0.014123889,0.031029595,-0.037509475,-0.054633375,0.033631653,-0.11738684,0.010236563,-0.05767159,-0.020031922,-0.03478759,-0.020728452,0.06157915,0.05683256,-0.038318466,-0.0019287677,0.033654477,0.013247393,0.018382914,-0.02979334,-0.03085457,-0.05497204,0.02005197,-0.019758906,0.08016634,0.036361557,0.100463845,0.08405878,-0.04966914,-0.08334178,0.079064585,-0.0012347426,0.06596144,0.0023870575,-0.0007316685,-0.0025836441,-0.06478457,0.023211442,0.033782452,-0.02416398,0.033944767,0.015277976,-0.0012835652,-0.06824608,-0.05248129,-0.04320084,-0.019364962,-0.010473587,-0.01617918,-0.03060315,0.0054352353,0.06559037,-0.007217275,0.05299729,0.0063462905,0.067378186,-0.009823321,-0.07901663,0.02604652,-0.08369505,-0.05403925,-0.04891484,-0.0910718,-0.052442193,-0.051786587,0.05668028,-0.008341331,0.0055558872,-0.030077718,-0.07741201,0.04942829,-0.015082968,0.015021983,-0.018603778,0.019843169,0.055820104,-0.05880217,-0.016731186,0.027635569,0.033161487,0.051430818,0.00907586,0.056439407,-0.019404117,0.009860519,-0.039645378,-0.045180816,-0.0016919109,0.057371456,-0.06605751,0.0021286537,-0.04653802,-0.0034238677,0.04243845,0.043509584,-0.13449758,-0.025412828,0.032840326,-0.020922497,0.07941993,0.032925826,-0.027597468,-0.07541687,-0.020235308,0.0254841,-0.065130375,0.033174407,0.018116232,0.029920472,-0.05750875,-0.063752934,-0.033351228,-0.029646805,-0.049181502,0.03847961,0.050553765,-0.03669208,0.05760926,-0.10332185,3.787341e-33,0.044920757,-0.021169038,0.01220037,-0.068582065,-0.009354061,-0.048154827,-0.04097705,0.03879915,-0.0593074,0.009674436,-0.012481315,-0.061289452,0.026094921,0.06414226,0.048623934,0.051516514,-0.074644364,0.016178109,0.016635008,0.07438991,-0.043143593,-0.0030114087,0.019610245,-0.0074041355,0.08836514,0.053857394,0.011698149,-0.04107412,0.113348655,0.00344267,0.09101915,0.030297348,-0.14119887,-0.004657357,0.05566792,0.043736245,-0.028366005,0.017906645,-0.066260144,0.031870842,0.029119825,0.029955983,0.024546124,-0.027050024,0.06445667,-0.06770465,-0.032011993,0.11353784,0.008364254,0.011667279,0.04041499,0.037680943,0.070123665,-0.007333128,0.01506029,0.083672926,-0.0309363,0.050739996,-0.027642267,0.01830991,-0.0024535987,0.07399408,-0.11638241,-0.01736245,-0.080732115,0.04614113,-0.0979606,-0.056782044,0.007429772,0.06235272,-0.002956041,-0.037651446,0.030660482,0.054806564,-0.0186215,-0.0063912976,-0.0871385,-0.047394898,0.06430396,0.005884938,-0.0065678675,0.021068767,0.08959201,-0.07928433,-0.04809252,-0.030764908,-0.005643384,0.052845746,-0.084285416,0.0060737836,0.0561658,-0.029152429,-0.03303159,0.050661758,-0.013434943,-5.261532e-33,0.13845946,-0.14166446,0.016638108,-0.047592297,0.027243765,-0.018076897,0.042153474,-0.035053305,-0.03033314,-0.016144486,0.04515165,0.025745569,0.04012444,0.0035187558,0.09740265,-0.009810849,-0.028481407,0.05247562,0.0036428603,-0.023402777,-0.02217231,0.054663077,0.079826124,-0.048769068,0.043617737,-0.04179581,-0.060836,0.061623856,-0.0017894648,-0.006609775,-0.023876466,0.0243361,-0.0047877165,-0.058759395,-0.06502538,0.086839415,-0.05644745,-0.05643563,0.042238697,0.040876307,0.003549754,-0.02035088,-0.014776085,0.0680529,0.068029605,0.023739051,-0.09010963,0.0513894,0.013453541,-0.035970736,-0.043715592,0.016393125,0.009655062,0.014005781,0.04601259,0.076751605,-0.017684523,0.020167092,-0.035797574,-0.10966622,-0.05371754,-0.0011791018,0.07800643,-0.0018331503,0.06048208,0.055376343,-0.00853615,0.03138382,-0.031047532,-0.089761585,0.09627463,-0.03415949,-0.03387067,0.050714355,0.0059821694,-0.014397248,-0.0913286,-0.005168362,0.0042915624,0.030889621,-0.011393074,0.05503274,-0.008992277,0.029689822,0.046286535,-0.108156964,0.029958753,0.050246567,-0.07831567,0.062265206,-0.042340938,-0.033546314,0.027292129,0.06604118,0.054912668,-3.8777e-08,-0.035922155,-0.0138704665,0.022487348,-0.10052691,0.005907162,0.022494432,-0.004385089,0.023481136,0.026117867,-0.06851933,0.051424537,0.058530163,-0.013608719,0.16309597,0.020425951,-0.024559582,-0.015992876,-0.036161836,0.008903967,-0.004646913,-0.08641499,-0.032123886,-0.09314829,0.04042567,-0.07695539,-0.04284517,0.02523067,0.047682386,-0.082959704,0.015864918,-0.03194931,0.069931984,-0.027048225,-0.08937849,-0.011941731,0.05134274,-0.013182355,-0.058228362,-0.044715572,0.07195415,0.09327726,-0.03983163,-0.055448644,-0.024277424,0.06148503,0.015492311,0.02586318,0.014736511,-0.0049559856,0.0015171488,0.06404053,-0.041579835,-0.05349863,-0.0382002,0.0016736531,-0.057559844,-0.0032206443,-0.058658935,0.019085253,0.044804044,-0.0007924867,0.04905096,0.20233862,-0.04523713 +3.5.99.11,"The enzyme, characterized from the bacterium Comamonas testosteroni CNB-1, converts 2-aminomuconate to 2-hydroxyhexa-2,4-dienedioate, unlike the enzymes from Pseudomonas, which produce (3E)-2-oxohex-3-enedioate (see EC 3.5.99.5, 2-aminomuconate deaminase). The enzyme also acts on 2-amino-5-chloromuconate.",384,1.0,-0.031156454,-0.07909752,-0.058927324,-0.038876623,0.011242015,0.011119446,-0.04840661,0.050909482,0.0057518305,0.0013534328,-0.003451267,-0.15804397,-0.026104739,0.03106857,-0.0222861,0.053796165,-0.035729505,-0.014429108,0.002619593,0.020216215,0.10773796,0.055269275,-0.022233313,0.04581122,0.02614724,0.005580347,0.038291335,-0.0033120716,-0.02925702,-0.072433345,-0.013354601,-0.05818392,0.009998591,-0.07960931,0.110891804,0.015168323,0.01058504,-0.08307404,0.102221705,0.032081507,0.08301313,0.054388046,0.0069902395,-0.04520429,-0.006330292,-0.009554008,0.035217557,0.031656288,0.08344642,-0.055966787,-0.05801288,-0.06797735,-0.054370683,0.07224027,0.009524296,0.08808406,0.021813696,0.020639068,-0.06915749,0.01267775,-0.020575317,0.035208426,0.05812512,0.028482936,0.03783534,-0.041244633,-0.008800798,-0.11581518,-0.036544234,-0.075348444,-0.092812695,-0.09820508,0.045164697,0.07609526,0.022769775,-0.043596603,-0.0065013603,-0.015397919,-0.005155669,-0.04570209,-0.016538808,-0.06545549,0.04697407,0.0862375,0.019935152,-0.029074475,0.013091723,0.0009910084,0.08178014,0.014617355,-0.020265082,0.028580414,-0.04178145,-0.02925367,-0.02971426,0.024020646,-0.0044470136,0.12380757,0.07822276,-0.0039271736,0.03557741,0.073351726,-0.02513728,-0.114915915,0.0011760775,0.04562108,0.043776594,0.08768982,0.060404863,0.0027077538,-0.030097365,-0.016047724,0.066695,-0.0015154718,-0.06632177,0.09884032,0.06538084,-0.02154884,-0.041562926,-0.0075981133,0.051517133,-0.07399679,0.07528582,0.041507967,-0.034466557,0.043018654,-0.072745785,7.5212064e-34,0.04575725,-0.033284158,0.010614409,0.018718848,-0.025826413,0.019024374,-0.087200515,-0.009626797,-0.039735068,-0.052202445,-0.016886782,-0.042135213,0.026724497,0.08139581,0.012999795,-0.040561136,-0.051660113,-0.010043736,0.044154253,0.013870902,0.01832807,0.08014391,-0.07853057,0.04130549,0.018166887,-0.0028221298,0.04365869,0.030534502,0.018591547,-0.01907841,-0.035411783,-0.042603448,-0.119742855,-0.045763012,0.008493438,-0.017748846,0.00040456266,0.017879762,0.0020917037,0.09089503,0.01493233,0.03922342,-0.023254618,-0.04195069,0.08683245,-0.04716021,-0.019043166,0.071199484,0.09812718,0.0053710956,0.014300997,-0.090949304,0.08036663,0.025712866,-0.022062434,-0.01188007,0.04074742,0.06773323,0.10292062,0.045621537,-0.0039658113,0.05726838,-0.021763407,0.046050236,-0.012752141,-0.004695936,0.006409389,-0.043416206,0.025326628,0.05247285,-0.10392682,-0.0049656695,0.013418352,0.016601892,0.025246909,-0.1426471,-0.091783926,-0.025682932,0.054018516,-0.047796242,0.07868195,-0.040941175,0.022965455,0.012230382,-0.04774246,0.005590819,0.00881414,-0.013334248,-0.06312294,0.02963462,0.10148562,-0.040623594,-0.06007975,-0.0029088138,0.03266465,-1.3384787e-33,0.020767137,-0.020690482,-0.019124992,-0.027619952,-0.071225554,0.0050441884,-0.013869957,0.026910363,0.020853164,-0.021589734,0.12789187,0.003633582,0.03893754,-0.03462614,-0.008057912,-0.03495659,-0.01176118,-0.044554036,-0.04625521,-0.04516842,0.10260087,0.032119423,-0.04274626,-0.01721496,0.032657754,0.07261038,-0.07316215,0.13821425,0.08606576,0.050414883,-0.058380123,0.019452251,-0.0041777096,-0.012001709,-0.042623725,0.051217597,-0.029284708,0.008973701,-0.0064842217,0.024152892,-0.06643092,0.024460033,0.025280526,0.06301723,-0.036225114,0.08282029,-0.05077263,-0.05871056,0.027540965,-0.022710271,-0.022459403,0.005892846,-0.040923707,0.03007391,-0.027461262,-0.049704835,-0.040003594,-0.015798524,-0.0073185056,-0.028717408,-0.032450352,-0.0072405976,0.064479545,-0.033367213,0.02195293,0.040826384,-0.048299775,0.05941468,0.030268881,0.07108467,0.06568319,0.01229379,0.009744143,0.021507686,-0.024658082,-0.032899655,-0.07816352,0.0028930623,-0.025183234,-0.032316733,0.0029066105,-0.018232029,0.012722264,-0.069814585,-0.017624639,-0.08163514,0.027377352,0.09007623,-0.045272604,0.043868616,-0.0062744753,-0.013270197,0.007517208,0.04528564,-0.012805304,-4.2923727e-08,-0.02025934,-0.10327375,0.05385719,0.01841934,-0.0349024,0.024778994,-0.008755923,-0.002852375,0.075955294,-0.07065927,-0.03647359,0.064601116,0.00876242,0.023320543,0.05369603,0.04114622,-0.058157075,0.035718847,-0.0017442245,-0.01342561,-0.058854338,-0.03519434,-0.12469296,-0.010792641,0.0029893338,0.017109275,-0.015102423,0.040792458,-0.015390651,0.01774155,-0.06853602,0.019342871,0.06292602,-0.026909696,-0.070431545,0.024899257,-0.09083988,-0.01859932,-0.057538163,-0.030389275,0.054766167,-0.03453353,-0.103241175,0.009845344,0.08387523,-0.040836606,0.027672425,-0.0013509315,0.01670977,-0.110202014,0.08629235,-0.07605894,0.018357115,-0.023302928,-0.10922358,0.05836035,-0.05570116,-0.009136561,-0.03574718,0.005778871,-0.020250212,0.0164125,0.1934955,0.017943999 +3.13.1.5,"The enzyme contains Zn2+. The hyperthermophilic archaeon Acidianus sp. A1-3 obtains energy by the conversion of carbon disulfide to hydrogen sulfide, with carbonyl sulfide as an intermediate. ",384,1.0,-0.071477555,0.018161014,-0.08429636,0.05296803,0.034401786,-0.02859462,-0.04288784,-0.004141777,0.02706168,-0.039220955,0.008381033,-0.061324604,-0.098526575,-0.0037591555,-0.045494232,0.06744498,0.00068945467,0.049507286,0.009964107,-0.038902484,0.124718495,0.039265044,0.084615454,0.024361178,0.0611493,-0.021960694,0.022770697,0.030394789,0.02859297,-0.011684598,0.009283196,-0.12640786,0.0063781175,-0.017143883,0.08011139,0.09042735,-0.015435878,-0.06797733,0.032350786,0.023775937,0.060472205,0.024278434,0.015851384,-0.0237949,-0.029332988,-0.0018535845,0.022616282,-0.031494565,0.013417161,0.020851377,-0.06726962,-0.09800412,-0.007485175,0.040269885,-0.013188211,0.103889644,-0.09661927,0.0025017096,-0.018944945,-0.039017234,0.069750845,0.03177231,-0.043271445,-0.030398764,0.06462647,-0.02394465,0.031077372,-0.050209075,-0.0076027913,-0.060498483,-0.080052994,-0.017588664,-0.025749959,-0.05166478,-0.0367089,0.065790795,-0.01797184,-0.068688735,0.045296222,-0.08378551,0.08136179,0.009732131,-0.010102186,0.1567019,0.01906943,0.044084623,0.04246667,0.055705924,0.01940188,-0.01474603,0.012984927,0.005755715,-0.03616901,-0.016799856,0.010223221,0.05658798,0.063353814,0.058565397,-0.00083886355,0.01791193,0.054425534,0.049620934,0.013746558,-0.1186984,-0.028400168,0.05158403,-0.021312544,0.14468673,0.030283745,0.099323675,-0.023157012,-0.01942902,0.022751633,-0.007197043,-0.039223436,0.10924889,0.05032269,-0.051734813,-0.089276016,0.019399976,0.02176012,-0.037502594,0.028838752,0.0077491063,-0.06455649,0.03453288,-0.12553209,3.9275015e-33,0.02551123,0.056241322,0.01592493,-0.02553268,-0.026665324,0.006203782,-0.09335138,-0.014661574,-0.051404156,-0.005036334,-0.13584931,-0.05583029,0.0560883,0.015501267,-0.06983827,-0.0218199,0.031218845,-0.004802214,0.031324886,0.009530869,0.011205872,0.048970558,-0.03761605,-0.034522265,0.010949699,0.04137795,0.024831891,-0.055421017,-0.0037687253,-0.015440516,0.06414249,-0.14718767,-0.10066376,0.012814625,0.1065561,0.020751927,0.004960645,-0.03460985,-0.023000887,-0.030416848,-0.007760355,0.0025177274,0.039884333,-0.020816168,0.048881218,-0.038026463,0.025253672,0.07189378,0.03868701,0.012561377,0.017601445,0.0038766803,0.01681394,0.012654392,-0.07192017,-0.009561821,0.016560072,0.09559951,0.038968716,0.014258684,0.011918295,0.042833135,-0.012383355,0.060712755,-0.049381148,0.054245837,-0.10767217,-0.026571045,0.017812774,0.06594362,-0.055126823,-0.0032970351,0.019134542,0.040762898,0.0204636,-0.014098611,-0.052390195,-0.062136006,0.043188475,-0.052854285,-0.06814329,-0.03793528,0.035189934,0.028116636,-0.08999054,-0.02000881,-0.032960273,-0.019515252,0.036507364,0.04550616,0.014396772,-0.0950717,-0.060840685,0.004435163,-0.029309293,-4.3842997e-33,0.054872643,-0.035941154,-0.013683767,-0.12661353,-0.023338974,0.06190951,-0.024847236,-0.055023946,-0.031812426,-0.026734168,0.11667957,-0.01194014,0.016634528,-0.0701556,0.07090038,0.06569354,-0.016318943,0.019100351,0.096821025,0.010035042,0.07375194,0.115589574,-0.018657044,0.043294262,0.029875832,0.0026306168,0.068795405,0.05032666,0.12147816,0.04819848,-0.032633867,0.0044981753,-0.02168772,-0.056120686,-0.062905446,0.06422134,0.0010164859,-0.024844198,-0.029703585,0.047062147,0.002215368,-0.027548801,-0.0068384437,0.07236361,0.07963206,0.04388883,-0.062215544,-0.02420403,-0.029576486,-0.02854961,0.09545589,-0.073690206,0.0072029303,0.010849064,0.04928933,0.05276658,-0.04103752,0.050312452,-0.07357249,-0.061215192,-0.038465757,-0.08352682,0.051250223,-0.014982401,-0.015672868,0.026754856,-0.05002729,0.002781426,-0.019629521,-0.038827807,0.08869187,0.042565603,0.003607721,0.040336594,-0.0060937875,0.008102891,-0.032638725,-0.021133924,0.019386241,-0.06032993,-0.019125784,0.070665725,0.05033197,-0.053872216,0.053892415,-0.035200287,0.028895218,0.075758696,-0.058737572,-0.045636304,0.031479307,-0.02702705,-0.084009804,0.047648314,-0.018412704,-3.3607872e-08,0.03614784,-0.014574969,0.08086939,-0.053446542,-0.041579083,0.024611987,0.076093495,0.02267323,0.01253733,-0.0025280223,-0.009807504,0.035958104,0.03407627,0.0010906117,0.02124614,0.022936745,-0.01783956,0.0540587,-0.056159284,-0.061593708,-0.012895568,-0.02026943,-0.05456757,0.025102798,0.06395886,-0.06428132,-0.019880228,-0.02820754,-0.017483154,0.005239263,0.024842275,0.013032552,0.045921315,-0.09168814,-0.07805672,0.058560185,-0.0746682,-0.050673082,-0.062159803,0.0027374676,-0.009924177,-0.035739195,0.005980307,-0.00029620473,-0.004279464,-0.03022572,-0.033659942,0.0008372955,0.025250005,0.07400327,0.07137338,-0.045432642,-0.031156724,-0.098091,-0.096028544,-0.04641371,-0.0009782619,-0.04999227,-0.05867227,-0.03811312,0.1146142,0.021593845,0.09903228,-0.014029108 +4.1.1.104,"The enzyme, characterized from bacteria, is involved in D-erythronate and L-threonate catabolism.",384,1.0,-0.02257046,-0.08292509,-0.06997152,-0.016972253,-0.038203992,0.037104335,-0.044853706,0.07794461,0.0114790555,0.025838155,-0.013351725,-0.005075072,-0.0392101,0.05958224,-0.0066270665,0.020542841,-0.025687914,0.047631867,-0.03692219,-0.0139702745,0.05591456,0.07230874,0.016896082,-0.038702767,0.09113059,-0.0051032295,0.057533115,-0.023703007,-0.040819313,-0.051493105,-0.013385755,-0.07130246,0.102785885,-0.0075365677,0.06523807,0.04765652,-0.087894686,-0.03954096,0.05594567,-0.04481163,0.026490333,-0.0019104189,0.004579939,-0.022735177,-0.08459795,0.011731849,-0.021808809,0.009695524,-0.019269817,0.0035045245,-0.028553236,-0.06294034,-0.048607744,0.02278773,-0.04552856,-0.0077003567,0.04552571,-0.008000813,-0.059207834,-0.011754981,0.044319738,0.032356955,0.04939145,0.030418666,0.042319484,-0.043532457,0.052032255,-0.042292804,0.01557163,-0.035276853,-0.055365175,-0.09977155,-0.05041028,0.08556844,0.036591806,-0.037357956,0.058668748,-0.007447724,0.013867746,-0.024976196,0.06664032,0.06996924,0.012793463,0.11094009,-0.028399298,0.062968075,-0.0024024325,0.013146774,0.050303385,-0.032761786,0.03420086,-0.07607793,-0.08412863,-0.04187597,-0.093981974,-0.010432467,-0.0014996023,0.03333713,0.06700137,-0.046086498,-0.0024226469,0.06523879,-0.04195656,-0.06411519,-0.06804167,-0.041319218,0.0049623265,0.041679215,0.013129073,-0.085537404,0.07493223,0.009424817,0.06845837,0.056717765,-0.0083459,0.057328954,0.08375242,-0.07954607,-0.057054725,-0.016554948,0.002992507,-0.066639476,0.084614955,0.07426124,-0.047936242,-0.017658398,-0.100406654,-1.9048175e-33,0.061901566,-0.0051355558,-0.020305095,-0.051164497,0.046491597,-0.028581511,-0.07348798,0.019971268,-0.047689613,0.0011938824,-0.09598762,-0.066907726,0.065588966,0.015015838,-0.032227945,0.027630849,-0.022614285,0.038929477,0.022799252,-0.006701473,0.026290972,0.04449594,0.0013637497,0.05525031,-0.005843479,0.05856144,0.0127838245,0.088786714,0.049092818,-0.034078445,0.0041651335,-0.14383279,-0.046486914,0.04824965,0.010176036,-0.0019891532,-0.049728382,0.062909745,0.010517101,0.01754599,0.01711888,0.07816681,-0.025014907,-0.0015762358,0.06336712,-0.06152696,-0.024656493,0.09756403,0.057252914,0.05985859,0.06830169,-0.08199729,0.1274073,-0.09450857,-0.079726376,0.05161837,-0.018914502,0.01805363,0.0406207,0.06548816,0.023003947,0.058840837,-0.015509468,0.06098091,0.059408884,0.026470924,-0.01657326,-0.072943375,0.025697635,0.079906695,-0.063578255,-0.05447606,0.07507958,0.0021984589,0.035646114,-0.06433929,-0.06660282,0.0052624196,0.03611013,-0.0047354526,0.003668626,-0.008149226,-0.03809329,-0.0017988775,-0.062072027,-0.0029567662,-0.036528483,-0.07473049,-0.06877924,0.068316005,0.020431168,-0.023696164,-0.09634801,0.004419014,0.054312292,-4.8627713e-34,0.09260986,-0.054022737,-0.0144597255,-0.025091758,-0.017251974,0.080322705,0.003429939,0.06366538,-0.013839247,0.006936044,0.08711255,-0.0031632935,-0.026986526,-0.0042133406,-0.0067115747,0.025874201,-0.029084519,0.0227436,-0.029216668,0.01669738,-0.024383418,0.055637624,-0.011524488,-0.032231025,0.039571844,0.026003312,-0.024990333,0.052315943,0.03829829,-0.02207893,0.060351137,0.0050139152,5.8074165e-05,-0.07284433,-0.07761934,0.09565593,-0.04288054,-0.008089768,0.00088462286,-0.046274003,0.008583181,0.050118357,0.019077875,0.045756478,0.02308249,0.04041213,-0.10208592,-0.005422886,-0.02468568,-0.048337985,0.020274444,-0.0048441617,0.054528087,-0.0016479514,-0.008603875,0.083634965,0.04051202,0.017693374,-0.09225705,-0.0060089137,-0.05158337,-0.07710972,0.074353844,-0.013923011,0.01610417,0.02146822,-0.040635858,0.04714014,0.025580605,-0.038160887,0.095616914,0.01989852,-0.053137757,-0.023437412,-0.10297285,-0.060807414,-0.08173218,-0.02664564,0.027288536,-0.006072605,-0.021869322,0.0005676231,-0.04070404,-0.018401872,-0.036116857,-0.11205323,-0.04244702,0.113437,0.012094471,0.07387941,0.012269231,-0.04001033,-0.023505302,0.0165805,0.09048261,-2.968861e-08,0.050358962,-0.08136278,-0.021146145,-0.006766184,0.02489073,-0.006933862,-0.0105721755,0.04773977,-0.002892405,-0.0023536384,-0.040393665,0.059038594,-0.069232225,-0.007528556,0.050385226,0.05021999,-0.023486108,0.0070213974,-0.0538004,0.028030844,-0.024874583,-0.009122933,-0.12560144,-0.0025341085,0.034734145,-0.02320551,0.0010015724,0.01653454,-0.038911898,-0.034373254,-0.0021371131,0.01724083,-0.014271171,-0.061648495,-0.08758797,0.005033566,-0.060879022,-0.096801415,-0.0059772376,0.028156715,0.034507163,0.04863861,-0.06731806,0.060781837,-0.03330877,0.03530281,-0.015784262,-0.0055385884,-0.010880118,-0.034894794,0.007710941,-0.020040892,-0.017349841,-0.07280601,-0.15127808,0.12326429,0.021710062,-0.046397828,-0.0118480455,-0.013887741,0.1106543,0.057455495,0.18984312,-0.055492166 +4.1.2.59,"The enzyme participates in methanopterin biosynthesis the archaeon Pyrococcus furiosus. The enzyme is specific for 7,8-dihydroneopterin 3'-phosphate. cf. EC 4.1.2.25, dihydroneopterin aldolase and EC 4.1.2.60, dihydroneopterin triphosphate aldolase.",384,1.0,-0.056100473,-0.033139586,-0.06000254,-0.064993545,0.047476243,0.022648204,-0.08441309,0.018956317,0.034354437,0.020718075,-0.05242664,-0.07666153,-0.13220327,0.03616838,-0.073277995,0.03926797,-0.12408703,-0.0012364365,0.018795827,-0.02114706,0.12110839,0.07741808,0.012411157,0.02016018,0.0057612173,-0.030490592,0.042048726,0.02022921,0.0026958252,0.025843251,-0.05675322,-0.06158382,0.059150293,-0.031356998,0.057037365,0.13689159,-0.012072902,-0.05488883,0.081454135,0.060936596,0.098295495,0.006805481,0.011896813,-0.01563327,-0.043548364,0.02417145,0.027435014,0.06505466,0.04314257,-0.033410147,-0.06881195,-0.030154046,-0.059452903,0.014287928,0.03586332,0.01279528,0.0005577659,-0.027916607,-0.0037566249,-0.03784859,0.051483747,-0.017012851,-0.022708243,0.014505747,0.039909493,-0.042912424,0.0234815,-0.065295875,0.026699565,-0.08839297,-0.043301158,-0.002980365,-0.028356528,-0.060452625,-0.03786808,0.06399108,-0.06036133,-0.02621996,-0.037744656,-0.07418504,0.1100558,0.024152147,0.019463979,0.06785915,0.06644359,-0.06564614,-0.0020590276,0.02167177,0.019916443,-0.035268772,0.019764924,-0.089769125,-0.030442908,-0.043051597,-0.06551406,0.0064733657,0.037315037,0.019381566,-0.021640696,-0.0008062409,-0.03725684,0.010434452,-0.03805587,-0.061221242,-0.07789737,0.0044899317,-0.015544941,0.07968927,0.043057203,0.07033668,0.014743784,0.012659637,0.021261675,0.08106948,0.014614877,0.059089284,0.0049968716,-0.10121225,-0.025342863,0.038791884,0.009788216,-0.027892936,0.10030619,0.07332372,-0.06489327,0.01456135,-0.11467755,3.721682e-33,0.05293123,0.005222155,0.004877201,-0.04585559,0.06746879,0.0072529996,-0.084232576,-0.007638082,-0.04233916,-0.039904457,-0.054203562,-0.04156106,0.11471157,0.00010457637,-0.05774838,-0.0136829745,-0.008310602,0.009435844,0.053512294,0.020097015,0.0337073,0.082241856,-0.09408333,0.056110956,0.061034422,0.049674954,-0.04399216,0.022109296,-0.00278363,-0.032499075,0.035874177,-0.111991,-0.110935986,-0.0069070286,0.058870267,-0.061895765,-0.043276515,-0.07842178,-0.03754832,-0.015485761,-0.019480899,-0.026218334,0.03142158,-0.04310167,0.045240216,-0.016574202,-0.021260228,0.058566727,0.019831449,0.06614905,0.021304123,0.024513138,0.08379824,-0.023373187,-0.1099211,-0.051552355,0.01156373,-0.06518695,0.06946514,0.04784071,0.01544376,0.0009509069,0.0059373993,0.0019577488,-0.025910888,0.004987552,-0.019780677,-0.04408715,0.039171252,0.13484897,-0.055643443,-0.0038819453,-0.021741921,0.007857447,-0.025713908,-0.006437681,0.004548631,0.032336954,-0.028671028,0.0014365515,0.03887955,-0.0024629906,0.055361133,0.016141279,-0.0693114,0.014976061,-0.017572332,-0.047291413,-0.004487817,0.043589383,0.0055396543,-0.038067415,-0.10433702,0.059696484,0.025810229,-3.9836093e-33,0.1116189,-0.083807416,0.08077261,-0.124835625,-0.08982457,0.10798968,0.019718315,-0.0043019885,0.012434303,-0.08000151,0.10476225,-0.0074950717,0.03181552,-0.038040172,0.03378397,0.030406956,-0.03189269,0.08880003,0.05531835,0.021768373,0.079522364,0.052561797,-0.059390694,-0.01967107,0.06252274,-0.041525096,0.013070925,0.05998276,0.04666428,-0.0073369136,-0.0194817,0.0026232621,-0.07160889,-0.04677619,-0.0896152,0.03183608,-0.09445855,0.00072182604,0.021421036,0.053148832,0.102186434,0.07239666,0.06199136,0.046035785,0.013949267,0.035965253,-0.045417454,-0.007202591,-0.0069700233,-0.021231193,0.049936138,-0.019888002,0.01282833,0.029621357,0.06489642,0.060458712,0.0422472,0.012895417,-0.011934888,-0.013776758,-0.012789061,-0.0490375,0.037613902,0.023814008,0.014087282,0.04025686,-0.05915387,0.05753603,0.020664506,0.051206257,0.06907159,0.011902767,0.02719588,0.07874695,-0.05730645,-0.009838353,-0.039316442,0.026482264,0.06371829,-0.0010207254,-0.004330618,0.009804762,1.3452786e-05,-0.038959995,-0.046403535,-0.028157871,0.1373131,0.081607334,-0.0009985898,0.014570795,0.033441305,-0.022736602,-0.028287271,0.002389443,0.04317888,-3.6531397e-08,0.05321775,-0.035958048,0.02476863,-0.039305173,-0.012325238,-0.029172042,0.09051848,0.019286346,-0.013595738,-0.04018764,0.033074662,-0.015174227,0.03440669,-0.011807093,0.05220714,0.033096626,-0.060705483,-0.0046309168,-0.011908904,0.0048826975,-0.027153239,-0.038581412,-0.08404968,0.04072555,-0.006676903,-0.05490244,0.003913647,0.03982246,-0.028294886,-0.0056545455,-0.00084193406,0.00023994743,0.0082791215,-0.101127535,-0.058104992,0.04283231,-0.101781614,-0.04522626,-0.033403,-0.056069806,0.001325178,-0.08451188,-8.89381e-05,0.006200298,0.013025083,0.031035798,-0.015743539,0.039819688,0.0075736553,0.028027656,0.09988966,0.03020254,0.049301837,-0.06448727,-0.12823871,-0.021507079,0.012643977,-0.06470315,-0.04758986,-0.03819799,0.07802284,0.0014379022,0.14094669,-0.028471561 +4.1.2.60,"The enzyme, which participates in a pathway for folate biosynthesis, is found in the Stramenopiles, a large group that includes oomycetes, various microalgae and brown algae, as well as in several bacterial phyla. It provides a bypass mechanism compensating for the lack of EC 4.1.2.25, dihydroneopterin aldolase. In the malaria parasite Plasmodium falciparum the enzyme is bifunctional and also catalyses the activity of EC 4.2.3.12, 6-pyruvoyltetrahydropterin synthase. cf. EC 4.1.2.59, dihydroneopterin phosphate aldolase.",384,1.0,-0.033237606,0.014194658,-0.099797286,-0.08036747,0.07331764,0.034288857,-0.07958482,0.048001632,0.065074004,0.016273342,0.008521381,-0.08310568,-0.05369158,-0.022491435,-0.05392873,0.06106327,-0.10940086,-0.003225536,0.0044005495,-0.07511691,0.049744092,0.038978588,-0.0012071045,0.004549772,0.015682599,0.0029653294,0.018723432,-0.02413641,-0.0104023395,-0.048460416,-0.027150568,-0.0680316,0.059915144,-0.040693223,-0.032534957,0.13987438,-0.02759835,-0.10708745,0.013279434,0.04930629,0.024884304,0.0034794759,-0.034605186,-0.035074923,-0.058226,-0.031454675,0.058147285,0.08624722,0.022232825,0.010228604,-0.057756793,-0.07954936,-0.07471761,0.056943607,0.03689774,0.013428217,-0.03353876,0.03081261,-0.0140702,0.050732195,0.043430094,0.0047868346,-0.022175087,-0.011860668,0.0039167046,0.000744174,0.03534966,-0.10458546,0.011607923,-0.029997699,-0.04526336,-0.06928727,0.008231785,0.0075247325,-0.0034567653,0.052042995,-0.0242158,-0.0137645705,-0.0027536976,0.0202218,0.03746388,0.05102744,0.028494008,0.017689157,0.09019798,-0.063917115,-0.043787286,0.0027413873,0.06255451,-0.0017183591,0.028228542,-0.064326115,-0.039956972,0.027253715,-0.06153987,0.073285006,0.044669926,-0.0020792861,0.054919586,-0.010648064,-0.022387194,0.031349022,-0.04197092,-0.041446846,-0.0408387,0.002559476,-0.01123625,0.15586583,-0.07413317,-0.0008989459,-0.014015842,-0.003966138,0.046328004,0.019675758,-0.020751301,0.027835278,-0.0154597815,-0.11640972,-0.03933458,0.038544774,-0.015802875,0.009118127,0.08512409,0.07415227,0.020118479,0.019516774,-0.11562281,3.4663198e-33,0.10219438,0.029494608,0.050424542,-0.0145937,0.049852807,0.032509144,-0.04359536,0.096340455,-0.02580604,-0.08124528,-0.062273294,-0.08263917,0.05580398,0.029092543,0.0029514767,-0.065900356,0.05416453,-0.029999612,0.08868881,0.042132117,0.040747616,-0.00713026,-0.02906394,-0.011231477,0.05487285,0.108539574,-0.029886326,0.03111736,0.036312144,0.016724868,-0.045554884,-0.1082474,-0.10412361,-0.045883793,0.021987578,-0.020593135,-0.093364246,-0.038057238,-0.042118385,0.042325757,-0.021701936,0.031706437,-0.009462585,-0.084024794,0.087366745,-0.02548378,0.0056219194,0.05646612,0.03817376,0.04895248,0.017234966,0.009186258,0.123512745,0.044597957,-0.051907487,0.01294897,-0.034866534,-0.018718276,0.019505244,0.032874957,0.06345894,0.048563756,0.0060566976,0.035117466,0.0029157829,0.021909066,-0.052754775,-0.031044124,-0.0010212791,0.041935496,-0.023862923,-0.0068927393,0.009959174,-0.0050235894,0.04477974,-0.056385465,-0.059918504,-0.03274069,0.0026501308,-0.0059032193,0.01838507,0.007361186,0.039520886,-0.015398379,-0.07488355,-0.0026384713,0.019248767,-0.019438844,0.032817755,0.021789752,-0.021258352,-0.09159966,-0.12871878,0.03595309,0.04119758,-3.2981484e-33,0.13168226,-0.13059594,0.078817606,-0.08191315,-0.02111515,0.08174467,-0.050386265,0.020097636,0.017553465,0.040586043,0.059429232,-0.044943724,0.022103747,-0.07057545,-0.053922944,-0.0021486734,-0.05857331,0.03661896,0.022491902,0.024482638,-0.02254382,0.043237332,0.028029429,0.0024386027,0.002647195,-0.0077939606,0.010871449,0.049825717,0.029254185,0.05583401,-0.08393711,0.020582162,-0.08573516,-0.041921567,-0.05461714,0.031894498,-0.07118487,0.06624993,0.07736471,0.042383023,0.08947533,0.053903364,0.018385157,0.03186716,0.06378463,0.114311635,-0.02355843,0.040033832,0.0013364134,-0.07191328,0.014229612,0.01852519,-0.019541621,0.047720134,0.03155388,-0.00093672326,0.020999074,0.0031666742,0.035385903,-0.033159047,-0.03598373,-0.09066959,0.014061546,0.00505436,0.07651595,0.006800169,-0.059257504,0.112917766,0.08865425,0.09900658,0.06724427,-0.08559547,-0.027390154,0.067135155,0.0010922509,0.036012646,-0.062009763,-0.06523007,0.02165792,-0.0007703468,0.020885851,-0.05996094,0.047012683,-0.0484588,-0.021803021,-0.048175875,0.10792987,0.049722787,-0.093675084,0.05551679,-0.0011562764,-0.0214871,-0.03349289,0.06544275,0.075826705,-4.188933e-08,0.05936095,-0.036908954,0.026593866,-0.022426415,0.013899208,-0.0009495921,0.0111039905,0.026570393,0.033508766,-0.030483464,-0.064670265,-0.017781127,0.05510591,0.014820268,0.0086039575,0.027201448,-0.02172318,0.028408496,-0.017767135,-0.007680422,-0.064138636,-0.012694196,-0.08194222,0.026933776,0.029187407,-0.05707107,0.0031288923,0.040737458,-0.0015354224,0.021039883,-0.06471782,0.044812657,0.022961283,-0.047549333,-0.08540877,0.023999318,-0.040454544,-0.060519814,-0.048399657,-0.03474606,0.02263364,-0.105965495,-0.028677927,-0.010772755,0.028282009,0.06051373,0.022863371,0.030100906,-0.006418512,-0.028536834,0.07159234,-0.005305194,0.042397365,-0.053915568,-0.096830934,-0.00088270457,-0.014509092,-0.08046007,-0.023458572,-0.075694315,0.016693547,-0.0049825152,0.13792542,-0.057612695 +4.99.1.10,"Inhibited by Ca2+, Mg2+ and especially Hg2+. SGR has very low activity with chlorophyllide a and none with chlorophyll b. It acts on chlorophyll a both in its free form and in protein complex. SGRL, on the other hand, is more active with chlorophyllide a than with chlorophyll a. The magnesium formed is scavenged by MCS (metal-chelating substance).",384,0.99999994,-0.07739745,-0.09455724,-0.05258321,-0.009527984,0.05555163,0.02522031,0.0134331025,0.041421156,0.05440846,0.0031828163,0.08079165,-0.00793737,0.0399054,0.0012427869,0.036944315,-0.021170547,-0.026491469,0.032755233,-0.0432306,0.023167586,0.028713226,-0.04768848,-0.065880634,0.011928017,0.019738171,0.039089303,-0.02378348,0.0011361593,0.0785588,-0.046959497,-0.0047816285,0.07763394,0.052781522,-0.015059842,-0.008155689,0.0557785,-0.06186235,-0.030836767,-0.035873998,-0.038433295,-0.0045312014,-0.04681947,0.042596556,-0.060931973,-0.021150084,-0.0019810435,0.0052239257,-0.06951137,-0.07721067,-0.041464146,0.0065966244,-0.048690073,-0.034478698,0.0036651825,-0.031448215,0.03157801,-0.104763314,-0.019004112,0.04784282,-0.047556885,-0.03644313,-0.03143179,-0.025212256,-0.034826223,0.04402908,0.030657563,0.0040304647,-0.031220414,0.13160631,0.017987784,0.005529444,-0.053479753,-0.06677094,0.028109359,-0.0058422424,-0.024901731,0.040910255,-0.039945282,0.02497065,-0.026019866,0.026223425,-0.008341534,-0.022648588,0.07452259,0.054599598,0.03324361,0.023974884,-0.013870762,0.031915758,0.045131028,0.082565375,0.06929382,-0.031457797,-0.030623294,-0.079811156,0.0779863,-0.057537526,-0.101466626,-0.016033135,-0.0034681326,0.04838996,0.0470168,-0.06274924,-0.0045913886,0.06303694,0.03435528,-0.0071841297,-0.0011075658,-0.042057984,0.0826496,0.07040246,0.05262597,0.019260734,0.00042255354,-0.021745123,0.05778739,0.099186294,-0.016092533,-0.029011816,-0.018358082,-0.032694068,-0.03724566,-0.05352457,-0.03135716,-0.012991834,0.06463507,-0.06489585,4.7071782e-33,-0.0057403813,-0.07502459,0.029636106,-0.026788414,-0.018174006,-0.010323349,-0.022383695,0.004634718,-0.003996719,-0.06899906,0.00032549293,-0.047983516,-0.01137917,0.021723503,0.0016582725,-0.021283465,0.018900162,-0.038781133,0.054233424,-0.06415767,-0.02917145,0.100400664,-0.0156051135,-0.03340565,0.028281687,0.025565684,0.0033783477,-0.070548475,0.033553135,0.0036032277,0.051342744,-0.011664872,-0.05440355,0.07943532,0.07284004,0.054284785,-0.0073715644,-0.019699652,0.025908012,0.032135647,-0.055811808,0.024105152,-0.06378048,0.009733918,0.07202506,-0.09656503,-0.053562272,0.04066593,0.001592418,0.044915073,0.101325765,-0.024280367,-0.08186628,0.048750635,-0.022656595,0.06691128,0.0010953048,-0.0017181296,-0.050212923,0.086401574,0.0058651413,0.065563835,-0.013229313,-0.012337517,0.125916,0.008639472,-0.09474244,-0.09349769,-0.060169015,-0.020610578,-0.067175925,-0.04137372,0.08533503,0.032401346,0.03101761,0.024197157,-0.016732171,0.0358664,0.06335095,0.115592696,-0.0013343861,0.02087801,0.036459513,-0.03334683,-0.16969156,-0.030029237,-0.012741608,-0.10675869,0.023165273,-0.03652841,0.06945912,-0.030907217,-0.02974483,0.069198646,-0.05788924,-5.578255e-33,0.041500047,-0.049967285,0.1250202,0.04302809,-0.04708626,0.026521927,-0.042247154,-0.1769031,-0.016109496,0.0016669967,0.080821544,0.030690622,-0.050512534,-0.07541606,0.0855275,-0.022807267,0.06895919,0.14211473,-0.07889898,0.016958024,-0.041250713,0.101152904,0.083213635,0.1107507,0.016860044,-0.039293434,0.024898328,0.04077814,0.046448875,0.056582585,0.051363368,0.013252117,-0.042472366,-0.084816515,-0.020379178,-0.056688953,-0.06604715,0.045563962,-0.009630262,-0.02922415,0.042495754,0.021629285,0.031952295,0.039943557,0.025904663,0.027243318,-0.010673011,0.035291027,0.014948465,-0.042213585,0.017950084,-0.05125091,-0.044518784,0.014164424,0.07891395,0.036182363,0.037360944,-0.04605695,-0.005412202,-0.01573624,0.038290218,0.0152048385,-0.030279823,-0.069437675,0.05881726,0.02975984,0.0436212,0.043039575,0.07322916,-0.04808561,0.06588536,0.063889034,0.09490081,-0.04145706,0.0034524542,0.047601055,-0.013538815,-0.06935788,-0.018111775,-0.11275922,-0.03611832,0.081058264,-0.013795168,-0.05936647,-0.068857916,0.0062152073,-0.08170325,0.023576856,0.058893114,-0.05387004,-0.07253099,-0.011440972,0.03498398,0.02070869,0.041328683,-4.008865e-08,0.0010442975,-0.0018421046,-0.010641152,-0.06179274,-0.05171673,0.081625044,-0.02628101,-0.038281217,0.06550676,0.07108623,0.0040420615,0.003949783,-0.03396279,-0.0703021,-0.023760024,0.036685243,0.0008976288,0.04209819,-0.037419084,-0.07984231,-0.035375737,-0.03877799,-0.066676,0.024368012,-0.017062413,-0.05957047,0.066831805,0.1100473,0.04370442,-0.049441405,0.052099213,-0.039500967,0.013620113,0.06003722,0.019615002,0.010841895,0.03158923,-0.058227435,-0.0154228145,0.04967145,-0.00807087,-0.03309438,-0.05178408,0.036921676,-0.087594524,0.030652044,0.0061222804,-0.010161558,-0.05226053,0.047407556,0.072825566,-0.059093907,-0.01822435,0.012590582,-0.11165824,0.012434942,0.028091222,-0.04590847,-0.010310531,-0.06559541,-0.0049314643,-0.06374073,-0.028393658,0.0883982 +4.99.1.11,"The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin.",384,1.0,-0.08656162,-0.017180845,-0.1319894,-0.047528107,0.08258361,0.029897565,-0.08849483,-0.03432495,-0.047219455,-0.0055257017,-0.013126079,-0.12108664,-0.023863764,0.0010436955,-0.055184532,0.02206609,-0.0981481,-0.028290378,0.034529615,-0.08153646,0.051916435,0.04850252,-0.034769304,-0.02386111,-0.045105204,0.025640214,-0.029046267,-0.07113327,-0.00084682263,-0.048270598,-0.028864129,-0.02255213,0.04772513,-0.067692526,0.07286278,0.09041326,0.006895739,-0.005765549,0.014131886,0.008237544,0.009047741,0.037990812,0.056358762,-0.0369364,-0.022633243,-0.030446064,0.037986837,-0.004444929,0.0319017,-0.060758077,-0.033103887,-0.015254311,-0.031206824,-0.0022472274,0.084531665,0.06261219,0.031308573,-0.07531973,-0.00013932548,-0.026181879,0.09808372,0.0270102,0.022049157,0.00045256573,0.006701966,-0.030005801,0.039218083,-0.101425834,0.077403426,-0.028575335,-0.06854393,-0.0077350326,-0.068606764,-0.029142195,-0.023234535,0.016860656,-0.0028590322,-0.090867005,0.058614723,-0.0014224757,-0.0021778743,-0.0075681466,0.044690486,0.0068457862,0.07010693,-0.079540655,-0.002805441,-0.065222405,0.019216027,-0.028549884,0.03953381,-0.040016543,-0.04113888,-0.033248316,-0.111020125,0.03623386,0.013577492,0.053734135,-0.029199691,0.008295564,0.03317599,0.050294105,-0.076945975,-0.05001136,-0.066818595,-0.016552227,0.0173487,0.11750622,0.034422327,0.12621668,0.046050005,-0.03570779,0.07384154,-0.010141399,-0.050146747,0.110074475,-0.017407047,-0.07005981,-0.004747914,0.09367858,0.041867726,0.033676475,0.0595166,0.0704514,-0.0022643572,0.043957118,-0.07875254,5.6224607e-33,0.07785686,0.085185625,-0.016568732,-0.0007987845,-0.009308243,-0.074269414,-0.10798938,0.03916021,0.0030272289,-0.067685775,-0.0054469123,-0.01153934,0.06352201,-0.034861885,-0.07860086,-0.022302732,-0.0291372,-0.031846933,0.0020149334,0.03032135,-0.03345433,0.04787379,-0.06252889,0.06688767,0.024291648,0.00763969,-0.022609688,0.033810772,0.057178013,0.038969018,0.0026339346,-0.08886624,-0.024282327,0.017113052,0.049289994,-0.011582081,-0.006864169,-0.038726464,0.004121506,0.009252806,0.08729793,0.0067346534,0.01115667,-0.01836874,0.054899085,-0.0044373646,0.018075248,0.12779883,0.06427208,0.015101965,-0.043288615,-0.030188618,0.040929087,-0.02554306,-0.046242323,0.0142725175,-0.0026903097,-0.054657213,0.0856724,0.028119154,-0.032255642,0.01045332,-0.028062545,0.08000444,-0.036918666,-0.002916327,0.004049154,-0.034565445,0.034929827,0.09969374,-0.08380793,0.014834782,0.0054279915,0.09840366,0.0140301855,-0.048464518,0.07162253,-0.06104065,0.094236314,-0.007348676,0.053612065,0.029305983,0.037000228,0.021942938,-0.02812358,-0.059785333,-0.04316974,-0.015148452,0.04010935,0.044126943,0.018362878,-0.05886112,-0.047103953,0.029531742,-0.020459738,-6.231844e-33,0.05581996,-0.061348144,0.026299518,-0.13880557,-0.07890529,0.0889525,5.9138285e-05,-0.030336276,0.07637656,-0.0013122465,0.10080211,-0.031537283,0.07260306,-0.041883454,0.012491136,-0.05063466,0.06987047,0.07137102,-0.0029514646,0.019536007,0.010595267,0.047880623,0.011922301,-0.052143216,0.019288342,0.029074239,-0.023701224,0.02487647,0.041705936,0.068569414,-0.048595827,-0.04179573,-0.10447486,-0.008285768,-0.09646695,0.01737927,-0.073896915,-0.0121355,-0.002996904,0.014507063,0.016028728,0.07961384,-0.017036045,-0.0008688304,0.055394497,-0.0041806796,-0.10058048,-0.032383945,0.020542316,-0.10581756,0.026793394,-0.0049943323,-0.06337972,-0.04836023,-0.051722597,0.062142555,0.040470503,0.04869708,0.06139424,0.012312015,-0.06766963,-0.020427205,0.037770927,-0.03502543,0.03430674,0.039711695,-0.03458729,0.05837739,0.07318428,0.007545039,0.018676132,0.08614548,0.09149736,0.018912401,-0.023326134,-0.036676727,-0.06659112,-0.005842093,-0.041254196,-0.055085644,0.0011538303,0.057740558,0.083269514,-0.05577629,-0.054833744,-0.07244994,0.022330206,0.07968113,0.0043810825,-0.004305476,-0.06178184,0.004894627,-0.08130443,0.029230395,0.00837331,-4.361122e-08,-0.0005954439,0.041089024,0.09849827,-0.018222006,-0.012036805,0.09598626,0.07232526,-0.082476534,0.07102869,-0.03319742,0.017458662,0.061818935,0.057264823,0.018989008,-0.033505786,0.053335443,-0.061948337,-0.043617684,-0.012299058,0.019895466,-0.0032462438,-0.010421998,-0.021808729,-0.0056631076,-0.057174295,-0.040092345,0.058430027,0.03991747,-0.060975887,-0.058894146,-0.06760282,0.02833159,-0.053164277,-0.00086638273,-0.08214599,0.020594604,0.010344013,-0.014072328,-0.05464938,0.0050050337,-0.019707814,-0.0017354065,-0.089423865,0.057768006,0.046230387,-0.050707877,-0.0007019392,0.06311503,0.011008513,-0.0013458019,0.04122953,-0.038154557,0.0028347287,-0.064728625,-0.038318656,-0.07086655,0.017990332,-0.064987205,-0.033941936,-0.00881741,0.053384986,-0.02985913,0.13941197,-0.04152337 +5.1.3.41,"The enzyme, characterized from the bacterium Escherichia coli, is involved in the catabolism of fructoseamines, amino acid sugar complexes that are formed non-enzymically.",384,1.0,-0.0063450523,-0.08709739,-0.1271398,0.035317894,0.014618157,0.030289683,-0.043172505,0.02117765,0.034531742,0.01506845,-0.00049306155,-0.032586414,0.00805114,0.044539362,-0.02673383,-0.0058723283,-0.071992464,-0.013743647,-0.030626476,-0.023816979,0.088833705,0.0086916145,-0.0044369576,0.009430086,0.034876887,0.046392556,0.073093474,-0.031776734,-0.026651448,-0.01914982,-0.0179358,-0.006856619,0.051157933,-0.0107277045,0.06707006,0.08089704,0.006013196,-0.07938793,0.08126669,-0.043813564,-0.05817745,0.010279165,0.04492527,-0.012574246,0.0055442075,-0.043236896,0.027558291,-0.0017828613,-0.0124520175,-0.0147947855,-0.031372525,-0.06870782,0.01240063,0.045048203,0.032509606,0.07215964,-0.0111889765,-0.07441266,-0.074315265,0.016557941,0.027201815,0.0302859,0.02610649,0.015258682,0.038798846,-0.043678753,0.006989693,-0.048443954,0.021952594,-0.040289275,-0.06843879,-0.04740879,-0.007985238,0.034669816,0.03811146,-0.08106493,0.01602786,0.045265533,0.02707503,0.02871826,0.023633111,-0.033815693,0.030623982,0.08407576,0.019599201,-0.0009098074,0.09611531,0.043285333,0.06775939,-0.00030851245,-0.03936831,-0.046422765,-0.017037276,-0.08515237,-0.047911175,-0.032938495,-0.011432848,-0.025658231,0.06193247,-0.022453086,0.012778172,0.025441138,0.041208297,-0.05431967,-0.08611357,0.0016946627,-0.009519925,0.11752425,-0.020809017,0.003554621,0.037213486,-0.0018233692,0.07086423,0.032453705,-0.03482725,0.073844045,0.047302745,-0.098082095,-0.018963074,0.00025406628,0.021114953,0.053569864,0.057669092,0.109669544,-0.046495352,0.027838597,-0.10682678,1.5111759e-34,0.048062064,-0.017070677,-0.006878742,-0.082652114,0.05071332,0.016398704,-0.044457324,0.053562425,0.0040414636,0.03366547,-0.08408685,-0.027853055,0.1034441,-0.017068094,0.036475535,0.012531278,-0.05560929,-0.023782939,0.068897046,0.03265998,-0.02143882,0.09505945,0.03663725,0.00789621,-0.04033969,0.060991444,-0.029217176,0.008431989,0.048068404,-0.022871722,0.0840156,-0.05427686,-0.10173709,-0.0040326575,0.08361758,-0.0048614023,-0.026345499,0.031316113,0.0064739897,0.06433805,0.04920106,0.029360486,0.013286645,-0.0372213,0.04437985,-0.025194352,-0.015053299,0.10672054,0.03432712,0.05611294,0.06306445,-0.028974231,0.06079424,-0.036633994,-0.091726944,0.045643535,-0.03243304,-0.039033268,-0.019301279,0.06573714,-0.058783837,0.01011653,-0.054859526,0.056131084,-0.031820282,0.0034664122,0.011046109,-0.03184587,0.030510372,0.09402868,-0.09852249,-0.031913057,-0.0022547287,0.013190404,0.07080216,-0.06617446,-0.12551317,0.0056262296,-0.014280648,0.060740776,0.015202069,-0.037387405,-0.0278049,-0.03666409,-0.060575474,0.004295759,-0.045382287,-0.06661359,-0.03463763,0.053703915,-0.031359047,-0.048177544,-0.05478853,0.030856365,0.070980065,-3.2835425e-33,0.11514054,-0.13364446,0.031948105,-0.09362871,-0.056265015,0.047171433,0.001924768,-0.06310399,0.06026558,-0.024667377,0.047551617,-2.8584314e-05,0.023415107,-0.011597359,0.02087805,0.023434661,-0.09607007,0.07213717,-0.0018155089,0.014316894,0.013081313,0.06548086,-0.008921465,-0.05786345,0.061006997,0.041693937,-0.02738426,0.10088807,0.05622561,-0.005652429,-0.014913868,-0.08690805,-0.000101669175,-0.11967853,-0.10181332,0.058839593,-0.067784816,-0.037506137,0.042497035,-0.0246601,0.014063691,0.09919268,-0.020787023,0.023099607,-0.006512857,0.049652413,-0.13997757,0.012185388,-0.048084628,-0.037706256,-0.030967394,-0.04564018,-0.001762159,-0.063101046,0.0030132027,0.019434597,-0.05919588,-0.0004113063,-0.046835214,-0.0062948004,-0.00094829453,-0.07507957,0.029734131,0.0014499207,0.047750324,-0.031906795,-0.008177569,0.02989631,0.05027434,-0.013274969,0.030489866,-0.0014459518,-0.0139804175,0.07194961,-0.0049213106,-0.05009904,-0.0906141,-0.03507109,0.0158635,-0.07496897,0.029171942,0.0037978324,0.004326374,-0.056795925,0.024323404,-0.049390465,0.03130339,0.10035868,0.05614698,0.021394135,-0.01653733,0.014731838,0.023254264,0.022020677,0.09085532,-3.2036738e-08,0.04638451,-0.080880664,-0.042608563,-0.038167555,0.014358146,0.061201625,-0.0058658714,0.0023066702,0.010575593,-0.0227238,-0.016380548,0.1149439,-0.021726876,0.037354637,-0.030311262,0.013208488,-0.04789044,-0.02464917,-0.016461115,-0.023320675,-0.090283126,-0.009176365,-0.12950389,0.06360829,0.014926759,-0.04209303,-0.013575211,0.0015473968,-0.09726036,0.024486577,-0.018445974,0.037233274,0.05849075,-0.08399164,-0.093951985,0.019065708,-0.002790571,-0.066009305,-0.009623615,-0.036073916,0.04022451,0.07360489,-0.088786,-0.023709998,0.014800289,-0.0035746356,0.011170189,0.01797062,-0.009392533,0.007212278,0.03901152,0.018756788,-0.039398294,-0.014448842,-0.091281734,0.00034628165,-0.036454782,-0.09248062,-0.020220114,0.0073916717,0.054997258,0.014017795,0.23089449,-0.07454194 +5.3.1.35,"The enzyme, characterized from bacteria, is involved in D-erythronate and L-threonate catabolism.",384,1.0,-0.02257046,-0.08292509,-0.06997152,-0.016972253,-0.038203992,0.037104335,-0.044853706,0.07794461,0.0114790555,0.025838155,-0.013351725,-0.005075072,-0.0392101,0.05958224,-0.0066270665,0.020542841,-0.025687914,0.047631867,-0.03692219,-0.0139702745,0.05591456,0.07230874,0.016896082,-0.038702767,0.09113059,-0.0051032295,0.057533115,-0.023703007,-0.040819313,-0.051493105,-0.013385755,-0.07130246,0.102785885,-0.0075365677,0.06523807,0.04765652,-0.087894686,-0.03954096,0.05594567,-0.04481163,0.026490333,-0.0019104189,0.004579939,-0.022735177,-0.08459795,0.011731849,-0.021808809,0.009695524,-0.019269817,0.0035045245,-0.028553236,-0.06294034,-0.048607744,0.02278773,-0.04552856,-0.0077003567,0.04552571,-0.008000813,-0.059207834,-0.011754981,0.044319738,0.032356955,0.04939145,0.030418666,0.042319484,-0.043532457,0.052032255,-0.042292804,0.01557163,-0.035276853,-0.055365175,-0.09977155,-0.05041028,0.08556844,0.036591806,-0.037357956,0.058668748,-0.007447724,0.013867746,-0.024976196,0.06664032,0.06996924,0.012793463,0.11094009,-0.028399298,0.062968075,-0.0024024325,0.013146774,0.050303385,-0.032761786,0.03420086,-0.07607793,-0.08412863,-0.04187597,-0.093981974,-0.010432467,-0.0014996023,0.03333713,0.06700137,-0.046086498,-0.0024226469,0.06523879,-0.04195656,-0.06411519,-0.06804167,-0.041319218,0.0049623265,0.041679215,0.013129073,-0.085537404,0.07493223,0.009424817,0.06845837,0.056717765,-0.0083459,0.057328954,0.08375242,-0.07954607,-0.057054725,-0.016554948,0.002992507,-0.066639476,0.084614955,0.07426124,-0.047936242,-0.017658398,-0.100406654,-1.9048175e-33,0.061901566,-0.0051355558,-0.020305095,-0.051164497,0.046491597,-0.028581511,-0.07348798,0.019971268,-0.047689613,0.0011938824,-0.09598762,-0.066907726,0.065588966,0.015015838,-0.032227945,0.027630849,-0.022614285,0.038929477,0.022799252,-0.006701473,0.026290972,0.04449594,0.0013637497,0.05525031,-0.005843479,0.05856144,0.0127838245,0.088786714,0.049092818,-0.034078445,0.0041651335,-0.14383279,-0.046486914,0.04824965,0.010176036,-0.0019891532,-0.049728382,0.062909745,0.010517101,0.01754599,0.01711888,0.07816681,-0.025014907,-0.0015762358,0.06336712,-0.06152696,-0.024656493,0.09756403,0.057252914,0.05985859,0.06830169,-0.08199729,0.1274073,-0.09450857,-0.079726376,0.05161837,-0.018914502,0.01805363,0.0406207,0.06548816,0.023003947,0.058840837,-0.015509468,0.06098091,0.059408884,0.026470924,-0.01657326,-0.072943375,0.025697635,0.079906695,-0.063578255,-0.05447606,0.07507958,0.0021984589,0.035646114,-0.06433929,-0.06660282,0.0052624196,0.03611013,-0.0047354526,0.003668626,-0.008149226,-0.03809329,-0.0017988775,-0.062072027,-0.0029567662,-0.036528483,-0.07473049,-0.06877924,0.068316005,0.020431168,-0.023696164,-0.09634801,0.004419014,0.054312292,-4.8627713e-34,0.09260986,-0.054022737,-0.0144597255,-0.025091758,-0.017251974,0.080322705,0.003429939,0.06366538,-0.013839247,0.006936044,0.08711255,-0.0031632935,-0.026986526,-0.0042133406,-0.0067115747,0.025874201,-0.029084519,0.0227436,-0.029216668,0.01669738,-0.024383418,0.055637624,-0.011524488,-0.032231025,0.039571844,0.026003312,-0.024990333,0.052315943,0.03829829,-0.02207893,0.060351137,0.0050139152,5.8074165e-05,-0.07284433,-0.07761934,0.09565593,-0.04288054,-0.008089768,0.00088462286,-0.046274003,0.008583181,0.050118357,0.019077875,0.045756478,0.02308249,0.04041213,-0.10208592,-0.005422886,-0.02468568,-0.048337985,0.020274444,-0.0048441617,0.054528087,-0.0016479514,-0.008603875,0.083634965,0.04051202,0.017693374,-0.09225705,-0.0060089137,-0.05158337,-0.07710972,0.074353844,-0.013923011,0.01610417,0.02146822,-0.040635858,0.04714014,0.025580605,-0.038160887,0.095616914,0.01989852,-0.053137757,-0.023437412,-0.10297285,-0.060807414,-0.08173218,-0.02664564,0.027288536,-0.006072605,-0.021869322,0.0005676231,-0.04070404,-0.018401872,-0.036116857,-0.11205323,-0.04244702,0.113437,0.012094471,0.07387941,0.012269231,-0.04001033,-0.023505302,0.0165805,0.09048261,-2.968861e-08,0.050358962,-0.08136278,-0.021146145,-0.006766184,0.02489073,-0.006933862,-0.0105721755,0.04773977,-0.002892405,-0.0023536384,-0.040393665,0.059038594,-0.069232225,-0.007528556,0.050385226,0.05021999,-0.023486108,0.0070213974,-0.0538004,0.028030844,-0.024874583,-0.009122933,-0.12560144,-0.0025341085,0.034734145,-0.02320551,0.0010015724,0.01653454,-0.038911898,-0.034373254,-0.0021371131,0.01724083,-0.014271171,-0.061648495,-0.08758797,0.005033566,-0.060879022,-0.096801415,-0.0059772376,0.028156715,0.034507163,0.04863861,-0.06731806,0.060781837,-0.03330877,0.03530281,-0.015784262,-0.0055385884,-0.010880118,-0.034894794,0.007710941,-0.020040892,-0.017349841,-0.07280601,-0.15127808,0.12326429,0.021710062,-0.046397828,-0.0118480455,-0.013887741,0.1106543,0.057455495,0.18984312,-0.055492166 +6.2.1.49,"The enzyme, found in certain mycobacteria, activates long-chain fatty acids by adenylation and transfers them to EC 2.3.1.111, mycocerosate synthase. The enzyme participates in the biosynthesis of the virulent lipids dimycocerosates (DIM) and dimycocerosyl triglycosyl phenolphthiocerol (PGL).",384,1.0,-0.07177211,-0.04194533,-0.049478017,0.016840333,-0.00625217,0.014790544,-0.046560034,0.01682589,0.017181698,-0.016815618,0.0067385677,-0.111601636,-0.03262906,-0.026952293,0.03409736,0.0062963483,-0.011999485,0.0042035272,-0.016718723,-0.07467022,0.10378649,0.10129119,0.007876414,-0.0075983168,-0.04966604,-0.019415155,0.0782649,-0.0020999552,-0.033473935,-0.0874011,0.01053892,-0.09225379,0.08173513,-0.037627645,0.059702512,0.06566834,0.009163499,-0.08602902,0.036561035,0.022096815,0.086394764,-0.0457816,0.00959696,-0.0024043785,-0.014760503,-0.030498888,-0.03880741,0.029995838,0.0051411185,-0.010531183,-0.05280357,-0.06892402,-0.05784041,0.011245892,0.03236697,0.037490014,-0.031296942,-0.0013210584,-0.01912284,0.025781408,0.071663074,-0.00466799,0.047257584,0.04677297,-0.06271814,-0.09142876,0.052067503,-0.069710895,0.025232881,-0.05617012,-0.11746376,-0.06269853,-0.037133902,0.06733302,0.011690806,-0.029332561,-0.018994886,-0.06594999,0.040401723,-0.03732811,-0.003959027,-0.056672756,-0.051927906,0.015467643,0.0012906718,-0.046871744,0.124255754,-0.0456501,0.015279016,0.07462753,0.08237148,-0.116448104,0.02666276,0.0052232333,-0.07754129,-0.026611479,0.072893746,-0.023191111,0.06361908,-0.0478393,0.009117418,-0.031465072,-0.04621899,-0.0221176,-0.052269913,0.04556481,-0.06166184,0.03410521,0.026539901,0.05130813,0.020691391,0.026160724,0.042345867,0.027698465,0.001766164,0.07645503,0.029273508,-0.07850576,-0.046941947,0.017418537,-0.0075255707,-0.10090281,0.027830707,0.03207389,-0.11926296,0.0564857,-0.08702647,3.2930398e-33,0.017151034,-0.030868128,0.005054432,-0.00036383126,-0.0048756246,-0.048089877,-0.08201029,0.046797644,-0.09921718,-0.06560084,-0.009721138,-0.042067237,0.067449935,0.12445802,-0.09014299,0.030992212,-0.012269984,0.04858146,0.091090575,0.019891605,-0.024548559,0.004161197,0.05673162,-0.028018294,0.012906051,0.077238895,-0.055709805,-0.017342655,0.05726732,0.008547549,0.00017279282,-0.10465663,-0.043237623,0.02133646,0.052601226,0.021103969,0.014476909,-0.07685667,0.052214324,0.025602547,0.016440606,-0.043547742,0.021121433,-0.038414124,0.0039697103,0.00013843965,-0.028334336,0.080175936,0.025117392,0.047806613,0.04314808,-0.07349166,0.06279231,-0.00046352437,-0.03699922,-0.017979871,-0.04625884,-0.0057146936,-0.0072615277,0.013037294,0.043211687,0.13165727,-0.06247531,0.0800555,-0.030826868,-0.022923557,-0.09399691,-0.033781968,-0.007890432,0.0637261,0.021203794,0.012503924,0.04629017,0.0064500477,0.064959705,-0.044403117,-0.0931261,-0.010475757,-0.034715302,0.01158797,0.02862276,0.027066872,-0.0009888563,-0.04618829,-0.03256084,-0.027494071,-0.08047865,-0.029090026,0.021216774,0.03144267,-0.038113274,-0.038442913,-0.0059260423,0.081153795,-0.025864111,-6.0856937e-33,0.10624926,-0.07987217,0.07266619,-0.0710072,0.011277226,-0.007763398,0.036206413,0.029572928,0.040410317,-0.012805495,0.06829554,0.0031230175,0.015187291,-0.0474397,0.05185432,-0.025242679,-0.052091632,-0.016211411,-0.07661401,-0.08236513,0.027942305,-0.024894707,-0.012072987,0.056877483,-0.024503257,-0.014604446,-0.04385086,0.058583237,0.00013409038,0.08529928,-0.013047629,-0.027444124,-0.071255825,-0.051055375,-0.027950738,0.007894398,-0.05767139,-0.012621941,0.018741285,-0.020787885,-0.010794959,0.080621496,0.008011561,-0.013739002,-0.0021054363,0.03708541,-0.0131373815,0.0229686,0.02894099,-0.08392091,-0.015208752,0.02998684,0.046589788,0.07031191,0.023375822,0.09103935,0.014518608,0.0326611,0.048753686,-0.109890975,-0.11612825,-0.08204069,0.08251854,-0.014852852,0.06721532,0.06682602,0.03492567,0.001418449,0.06427225,0.025501503,0.08056885,0.05835412,-0.049936093,-0.018481221,-0.08106198,-0.03646448,-0.045174737,-0.03863103,-0.0420265,-0.0017674866,0.081997655,-0.027583571,0.023286471,-0.12712304,-0.03533277,-0.040682647,0.044161648,0.09804921,-0.01032124,0.06284962,-0.022662932,0.019073404,-0.07324305,-0.024503076,0.03749326,-3.8865725e-08,0.014491922,-0.05068389,0.031540938,-0.021969546,0.02185192,0.04267219,0.017044393,0.05573623,0.09748944,-0.013501839,0.009102079,0.09047266,0.08305502,0.0118360035,0.06382106,0.039935153,-0.059099443,0.0019997861,0.035401247,-0.04792433,-0.079731405,-0.037205283,-0.039904207,0.05367599,0.016719509,-0.057184238,0.031308442,0.07161149,-0.011528051,0.030737016,-0.0022313884,0.0446032,-0.029333964,-0.011593502,0.0020868483,-0.017414963,-0.05962434,-0.034089584,-0.04884704,0.09082956,0.05517224,0.039858837,-0.07855584,0.012505001,0.027016494,0.005488736,-0.027506074,0.009395236,-0.016254194,0.04356569,0.0029909117,0.015785366,-0.053301193,0.021117637,-0.08237139,-0.020716388,-0.05620323,-0.023808496,-0.06623016,0.029435564,0.038472,0.056154512,0.18734336,-0.027269725 +6.3.2.50,"This fungal enzyme, isolated from Magnaporthe oryzae, is an non-ribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) hybrid protein that consists of condensation (C), adenylation (A) and peptidyl-carrier protein (PCP) domains in the NRPS portion and a ketosynthase (KS) domain in the PKS portion. ATP is required for activation of isoleucine, which is then condensed with acetoacetyl-CoA. Cyclization and release from the enzyme are catalysed by the KS domain.",384,1.0,-0.03740825,0.042720955,-0.11485404,-0.022972545,0.082587786,0.015251814,-0.065493874,0.04379093,0.035478048,-0.012596492,0.054051816,-0.0015017658,-0.015464364,0.04512298,-0.13460366,-0.0017122909,-0.014594992,0.04914665,-0.0021517398,-0.025831724,0.050829053,0.036564626,0.03978338,0.0018095606,0.0068447343,-0.016650684,0.11925372,-0.010200414,-0.0005339051,-0.10508142,-0.05791848,-0.03357089,-0.029156446,-0.056038156,0.06518124,0.10725202,-0.02000879,0.013678128,0.054487415,-0.038080327,0.05761485,-0.084504865,-0.035694074,-0.017024294,-0.09088755,0.0112135485,-0.040065523,0.013251655,0.058606748,-0.046647776,-0.039669737,-0.051674426,0.021038372,0.007931571,0.01596545,0.023560086,-0.015468937,-0.0575083,-0.032336406,-0.0039721997,0.020921204,0.022406477,-0.0150018465,0.058499496,0.00025746477,-0.0634206,-0.02022911,-0.00761026,-0.04194506,-0.06682478,-0.086812824,-0.080957286,-0.018108299,0.09340342,0.066739894,0.03163467,-0.007994966,-0.02156741,0.060251277,0.014869216,0.041249298,0.053152468,-0.034662407,0.041155703,-0.02905791,-0.008112126,0.013930169,0.090574995,0.04479507,-0.049123198,0.014237235,0.046359114,0.024886385,-0.0039122496,-0.09161619,0.05589412,0.03927113,0.05760606,-0.010630914,-0.006697731,0.006394334,0.03359314,0.0415747,-0.084888,-0.04476468,0.0028824182,-0.011182092,0.06262039,0.08692207,4.115232e-05,-0.03092348,0.0018226546,0.013511009,-0.07917794,0.040675312,0.08402146,0.018281907,0.007933344,0.011752308,-0.02049923,0.0015407538,0.0046315207,-0.022575667,0.069227956,-0.04477018,0.03228908,-0.04381501,3.958838e-33,0.037991527,0.06273501,0.025396012,-0.037982002,-0.0034387135,-0.022402184,0.005339451,-0.024205962,-0.030039974,-0.017193869,-0.07989207,-0.10124741,-0.044198338,-0.001112618,-0.01627123,-0.014760308,-0.03407414,0.027893918,-0.0048151,0.064388126,0.012251188,0.059607707,-0.061691895,0.02707757,0.08299192,0.02692934,-0.042469382,-0.047800496,0.04009916,-0.0274224,0.037323132,0.026540576,-0.16741848,0.007991561,0.037774794,-0.06897105,0.017859912,-0.046801522,-0.020179361,0.044492293,-0.062208664,-0.036803287,-0.0181545,-0.073266335,0.07989894,-0.042432677,-0.060040258,0.12720598,0.010999117,0.043209754,0.09887309,0.021696972,0.07122927,0.012081335,-0.038702097,-0.0006529774,-0.039337207,-0.01858734,0.04441182,-0.011546392,0.022774044,0.040712256,-0.03233699,0.046338055,-0.011674636,-0.034391373,-0.107864805,-0.073390335,0.035689425,0.069480635,-0.043423615,0.047941606,-0.0018122289,0.026161889,0.013842081,-0.092837475,-0.08870094,0.0010430401,0.04122312,0.057901673,0.010686823,0.016927404,-0.010024794,-0.07797374,-0.0060235723,-0.022611275,-0.022644907,0.025227722,-0.05330878,-0.005022345,0.021504104,-0.011408491,-0.061175697,0.08073059,0.04436612,-5.8308987e-33,0.16932704,-0.088761605,0.046018627,-0.07478543,-0.0629834,0.053759426,0.0030630562,0.06346677,-0.0006947174,-0.04964426,0.027268648,-0.045010254,0.0427766,-0.055808213,0.03527512,0.0014292463,-0.034244217,0.1278261,0.009530148,0.03927519,-0.077896945,0.08600701,-0.030072184,0.062292896,0.05652964,-0.019122137,-0.036162928,0.12803769,-0.007419425,0.07895331,0.040426195,0.0449839,-0.03321776,-0.009721694,-0.04409314,0.052352242,-0.050948445,-0.017068686,0.029221382,0.036331795,-0.07074265,0.048907254,-0.039589737,0.042748246,0.0023193553,0.06994424,-0.04721865,0.041145798,0.033241406,-0.081995845,0.050783955,0.0033512881,0.039512925,0.0026222032,0.0109737385,0.04367274,-0.034266118,0.032908127,0.046640567,-0.06995344,-0.03171852,-0.039029215,-0.021053005,0.0090520205,0.028442524,0.07447808,-0.06226021,0.029986411,0.0072373147,-0.004920125,0.034542274,0.035870556,0.005643988,0.05623384,0.03982485,0.0061989427,-0.017643793,-0.029263698,-0.051364914,-0.017075788,-0.01244338,-0.021112146,-0.0014262466,-0.07378228,-0.019562546,-0.02940363,0.03339598,0.032589216,-0.06544736,0.027019564,0.006583945,0.04132974,-0.05877939,0.09785791,0.081275485,-4.8345782e-08,0.080243416,-0.00784271,-0.013383503,-0.113158606,-0.028524924,0.01436398,0.039956596,-0.0797983,0.050802253,-0.015852971,-0.047975384,0.08130156,0.0013550691,0.083373345,0.068635225,-0.016923359,0.029573925,0.08490743,0.008141213,-0.009063875,-0.029431531,-0.046643563,-0.08656276,0.044084832,-0.013061727,-0.017432611,0.088588804,0.019794095,0.07343252,-0.015094275,-0.031159982,0.046960995,-0.0138930185,-0.04088159,-0.024617787,0.11952726,-0.070566885,-0.046555433,0.025921648,-0.020345325,-0.0026697153,-0.05124228,-0.050734445,-0.07039915,-0.0561089,-0.06881127,0.00035017065,-0.028984917,-0.041324016,-0.063768536,0.01978787,-0.016960548,-0.0107078245,-0.103715494,-0.053714633,0.023996377,-0.008305684,0.012705092,-0.079137705,-0.13077639,-0.061085343,-0.023982182,0.1698596,-0.011605507 +6.3.2.51,"A key enzyme in the production of coenzyme A. The eukaryotic enzyme requires ATP, in contrast to the bacterial enzyme, EC 6.3.2.5, phosphopantothenate---cysteine ligase (CTP), which requires CTP.",384,0.99999994,-0.07850831,-0.023038095,-0.012289494,-0.033231944,0.0017553547,0.040956683,-0.101426534,0.02846141,-0.009307092,0.024894165,0.046053212,-0.106538214,-0.07291594,0.07246185,-0.034147065,-0.032312077,-0.035465866,-0.013425595,0.023544934,-0.06258891,0.06924169,0.018608408,-0.030054094,0.0025346435,0.028138982,-0.03068029,0.09434365,-0.039413083,-0.013409737,0.00848613,-0.12680037,-0.037864257,0.03384431,-0.034067087,0.06363442,0.11264283,-0.036328826,-0.07992117,0.047294427,0.010639255,0.030539235,0.050324388,0.008361218,0.032331575,0.0037156644,0.04460215,0.040112816,0.04871891,-0.04820976,-0.085320115,-0.06359969,0.011756955,-0.039851315,-0.012017465,-0.035388906,0.071500644,-0.022359878,-0.015177749,-0.011905888,-0.040630806,0.005373221,0.0014728578,-0.029387522,0.022627011,0.072894156,-0.029872544,0.051840916,-0.002728242,-0.0013419996,0.008735817,-0.0937872,-0.05353031,-0.05243193,0.06101012,-0.045398112,-0.0073984647,-0.021825092,-0.11431187,0.020734372,0.07026357,0.017167076,-0.012043379,-0.027090585,0.021341955,0.0977276,-0.069969356,0.010764097,0.015051211,0.030677443,0.05531068,0.0008519043,-0.020642992,0.009111076,-0.01154912,-0.08154454,0.084802546,0.03678367,0.0043922537,0.01723998,-0.059784,0.02759589,0.09681014,0.056041718,0.002788096,-0.008054254,0.02636013,0.0056363665,0.05006117,0.04117015,0.08138509,0.0005606301,0.050132215,0.024217647,-0.0862488,0.04432493,0.09726405,0.0066650026,-0.059048563,0.03491121,0.09309849,-0.019155873,-0.061929964,-0.020308755,0.086423196,-0.033608854,0.023262236,-0.09316914,-1.3116855e-33,0.030906321,0.024678329,-0.0072520724,-0.012493921,-0.023110643,0.027632289,-0.06086081,0.014107997,-0.08898369,-0.11489133,-0.09807844,-0.072533034,0.039465234,0.012532096,0.01538176,-0.007900649,-0.011273363,0.017718475,0.07018217,0.066419154,-0.04688058,0.020815134,0.00270252,0.028289573,0.045988683,0.010601118,-0.0154948495,0.024034875,-0.013041402,-0.005530696,-0.0110560255,-0.061541516,-0.08475745,0.019897172,0.02314989,0.010247501,-0.065097794,-0.0621064,-0.029680667,0.043323293,-0.019452581,0.026128646,-0.01334362,-0.010072375,0.054581515,-0.077576645,-0.05699697,0.059388157,0.01820078,0.04036648,0.0755382,0.0074333795,0.03985445,-0.033967502,-0.0057956576,-0.005859914,-0.010137758,-0.0013378432,-0.00034745008,0.07493013,0.010843265,0.05297256,-0.070901886,0.109359145,-0.039800663,0.07836799,-0.082786545,-0.0711428,0.03557833,0.047047045,-0.10279464,-0.05635121,-0.00017240252,0.018692927,0.04748413,-0.020349354,-0.0061991783,-0.035212077,0.011621619,0.04509187,-0.023251267,-0.038520243,0.0037403498,0.004454854,-0.017758243,-0.044388704,0.013145479,0.047416642,0.07211094,0.016476993,0.12307906,-0.021361336,0.0067115566,0.08728949,0.043623902,-3.7089104e-34,0.08067305,-0.06505854,0.011937876,-0.09797772,-0.0321252,0.039959967,-0.019488582,-0.16496967,0.019119672,-0.056017455,0.08070452,-0.06864127,-0.0014139736,-0.011507943,-0.017424619,-0.0075242976,0.012980079,0.09040076,0.024654657,0.026549699,0.010558148,0.06102552,0.03335879,-0.008822274,0.0224208,0.006967929,-0.069518894,0.077639565,-0.012507323,0.034429308,-0.05990507,-0.02622792,-0.03088401,0.017759496,-0.055890754,0.096890636,-0.06407705,0.028181808,0.068546794,0.055413816,0.061445747,0.07073715,-0.031457677,0.07335902,-0.020655923,0.025545787,-0.0030028569,-0.062405348,0.010825053,-0.018451938,0.025526032,-0.008668065,-0.012301303,-0.040172588,-0.022255404,0.062582195,-0.0062645874,0.06143734,0.032310676,-0.023874179,-0.03723989,-0.011491363,0.030786289,0.026693424,0.07931772,0.052900884,-0.060863223,0.060589783,-0.0051388354,0.019826602,-0.004424563,0.098343804,0.041892443,0.022292743,0.012754141,-0.035404056,-0.10209309,0.03667629,-0.016583482,-0.03745629,0.009016177,0.04800085,0.0107923765,-0.040375926,-0.06264519,-0.066124626,0.010171931,-0.023620715,0.0035013221,0.053238574,-0.0065758033,-0.041733835,-0.044850048,0.016041517,0.07659347,-3.1878745e-08,0.025602443,-0.014401698,-0.023349376,-0.10296675,0.058116794,0.066583745,0.056896128,-0.037416942,0.07868254,0.04715879,-0.00955236,0.088719055,0.030666647,0.04340472,0.04944645,0.0074379304,-0.07680352,-0.020571819,-0.022886673,-0.0010858865,-0.046217516,0.0054927464,-0.10582746,0.082771935,-0.031645093,-0.0346216,0.009115886,0.077159226,-0.026694035,-0.0034329456,-0.023272336,-0.020894516,-0.0017475248,-0.030526437,-0.10930441,0.013843841,-0.0031490652,-0.06750777,-0.10146385,0.013651413,-0.008045996,-0.008045636,-0.114813045,0.022160936,0.09240526,0.004882152,0.0413477,-0.019805802,-0.02995951,-0.015847666,0.0570022,-0.06410338,0.03104594,-0.06759059,-0.038015082,-0.03223436,0.011248907,-0.07005404,-0.08937813,-0.058720786,0.0101513965,0.039764192,0.21286231,-0.10001896 +6.3.3.7,"The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.",384,0.99999994,-0.086071506,-0.022480762,-0.12549642,-0.03771023,0.073715724,0.025079297,-0.100501046,-0.03705373,-0.039469752,-0.0119779045,-0.0039730775,-0.10359466,-0.03079306,-0.020669363,-0.049383357,0.033874214,-0.08016793,-0.02359246,0.045348413,-0.05278542,0.048440333,0.040653676,-0.02737495,-0.018816402,-0.046126604,0.018824032,-0.03718346,-0.07781271,-0.01005596,-0.040233474,-0.042819083,-0.024961041,0.033497684,-0.061494544,0.0869446,0.07286406,-0.01145371,-0.032592595,0.02236408,0.014555591,0.027076442,0.040534582,0.044699777,-0.048612677,-0.01212348,-0.033920437,0.0536817,0.0048833075,0.007826006,-0.0753157,-0.068087555,-0.02882263,-0.04408394,0.007349002,0.08662663,0.0689502,0.027128391,-0.061663564,-0.0027797492,-0.0307361,0.09433882,0.020782467,0.021718964,-0.011537977,0.0068681114,-0.005962924,0.053175014,-0.07640525,0.085595325,-0.025449364,-0.10049885,0.003456309,-0.066316344,-0.019258982,-0.025548184,0.011595922,-0.005522807,-0.08259392,0.06974422,0.0031855814,-0.008944539,-0.018200215,0.022251422,-0.014369075,0.062982686,-0.074718736,-0.00040919596,-0.02602468,0.033797376,-0.0015729527,0.020953842,-0.036233522,-0.03916903,-0.01835245,-0.12901351,0.022297485,0.036453195,0.087114275,-0.024419509,-0.006155921,0.0316269,0.04607916,-0.034257423,-0.05227686,-0.061506156,-0.02985768,0.051040158,0.11085766,0.048395112,0.11491913,0.038212497,-0.02457552,0.058462113,-0.014353656,-0.05642476,0.100380376,-0.03652468,-0.08842311,0.014380842,0.087712,0.048707206,0.016695486,0.07382841,0.046414036,0.0051567587,0.051669173,-0.096572205,4.4410893e-33,0.07334061,0.10448672,0.0006224431,0.012862488,0.009341157,-0.06152346,-0.1092468,0.021281086,-0.020361625,-0.042652432,-0.036057845,-0.007423346,0.08591223,-0.023157468,-0.05948873,-0.022766538,-0.038556263,-0.032588992,0.023508877,0.024703776,-0.024888739,0.029708512,-0.07010057,0.05713683,0.011236328,-0.02269197,-0.030432852,0.057956792,0.043282196,0.03804615,-6.0425533e-05,-0.08371457,-0.023212673,0.008860321,0.08362892,-0.04096195,0.0022823308,-0.05428934,-0.01944847,-0.011798935,0.11416407,0.021910794,0.02322051,-0.0051290803,0.05666175,-0.008647457,0.011981607,0.13148819,0.070502385,0.023160059,-0.03029923,-0.019385504,0.04766153,-0.015386638,-0.069222465,0.018695772,-0.01449607,-0.050375015,0.101469986,0.020217806,-0.06532843,0.016886486,-0.012796368,0.062474873,-0.037692983,0.01985931,-0.0214417,-0.007329134,0.039516248,0.10370051,-0.06065216,-0.012267976,-0.010072877,0.086914614,0.009871617,-0.040423036,0.068272725,-0.07387577,0.09356609,-0.008355251,0.045341823,0.019276546,0.028450409,-0.0009475995,-0.030710608,-0.045915,-0.043660298,0.017706176,0.050300173,0.060386322,0.027928999,-0.052482564,-0.036275577,0.033520266,-0.01635404,-4.8197083e-33,0.057177104,-0.047236547,0.0056540286,-0.1482409,-0.08700543,0.06490387,0.018492818,-0.04534651,0.09223836,-0.0057088085,0.11810584,-0.031817473,0.09088574,-0.052144703,0.023214448,-0.042943105,0.053340126,0.06708628,0.028224576,0.013956872,0.030132432,0.038329687,-0.024307046,-0.057754833,-0.024599941,0.041086834,-0.025916453,0.020125221,0.054600343,0.05126905,-0.029004354,-0.035580393,-0.06899992,-0.0023157676,-0.1200713,0.00460502,-0.0726937,-0.00035868722,0.012415034,0.017830636,0.02626281,0.07682048,-0.016468218,0.023074552,0.05964675,0.0019112823,-0.07989354,-0.038550153,0.00955464,-0.0813526,0.03191909,-0.018271875,-0.06550602,-0.053573564,-0.03500792,0.050532047,0.017403696,0.052038092,0.02513137,-0.00015030713,-0.059653725,-0.01988818,0.04802892,-0.028741391,0.058534216,0.04178699,-0.037202038,0.07128131,0.06450649,0.01766008,0.018300945,0.10836231,0.045895826,0.011732418,-0.010277819,-0.0355169,-0.08552085,0.022901805,-0.037553903,-0.028258735,0.011355959,0.036364164,0.09297565,-0.05505349,-0.08691348,-0.08813932,0.0101849465,0.06836924,0.031536963,-0.0024481614,-0.06848405,-0.0256987,-0.06732917,0.034825698,0.0040833866,-3.8696218e-08,-0.02248976,0.054467414,0.082902774,-0.01109573,-0.027815897,0.08163631,0.07730227,-0.07096113,0.06419976,-0.025903473,0.003224395,0.056281984,0.052238595,0.020190917,-0.02387204,0.04594549,-0.06049361,-0.03741283,-0.022224072,0.01647468,-0.002022079,-0.014597236,0.0022554263,0.023053078,-0.03951553,-0.045511603,0.054149527,0.040196016,-0.062303238,-0.06826652,-0.07840117,0.014714626,-0.049361512,-0.013147751,-0.0994811,0.010068428,-0.00075766386,-0.016857374,-0.06284761,0.03564329,0.00038043328,-0.024608783,-0.097183265,0.055656683,0.04084214,-0.0497628,-0.0021112966,0.06288564,-0.0021515703,-0.009901066,0.052044597,-0.022908477,-0.022009468,-0.054451797,-0.040205084,-0.07054962,0.013816538,-0.031230152,-0.036134724,-0.016338237,0.07300014,-0.00671125,0.14562868,-0.04397875 +6.3.5.12,"The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.",384,0.99999994,-0.086071506,-0.022480762,-0.12549642,-0.03771023,0.073715724,0.025079297,-0.100501046,-0.03705373,-0.039469752,-0.0119779045,-0.0039730775,-0.10359466,-0.03079306,-0.020669363,-0.049383357,0.033874214,-0.08016793,-0.02359246,0.045348413,-0.05278542,0.048440333,0.040653676,-0.02737495,-0.018816402,-0.046126604,0.018824032,-0.03718346,-0.07781271,-0.01005596,-0.040233474,-0.042819083,-0.024961041,0.033497684,-0.061494544,0.0869446,0.07286406,-0.01145371,-0.032592595,0.02236408,0.014555591,0.027076442,0.040534582,0.044699777,-0.048612677,-0.01212348,-0.033920437,0.0536817,0.0048833075,0.007826006,-0.0753157,-0.068087555,-0.02882263,-0.04408394,0.007349002,0.08662663,0.0689502,0.027128391,-0.061663564,-0.0027797492,-0.0307361,0.09433882,0.020782467,0.021718964,-0.011537977,0.0068681114,-0.005962924,0.053175014,-0.07640525,0.085595325,-0.025449364,-0.10049885,0.003456309,-0.066316344,-0.019258982,-0.025548184,0.011595922,-0.005522807,-0.08259392,0.06974422,0.0031855814,-0.008944539,-0.018200215,0.022251422,-0.014369075,0.062982686,-0.074718736,-0.00040919596,-0.02602468,0.033797376,-0.0015729527,0.020953842,-0.036233522,-0.03916903,-0.01835245,-0.12901351,0.022297485,0.036453195,0.087114275,-0.024419509,-0.006155921,0.0316269,0.04607916,-0.034257423,-0.05227686,-0.061506156,-0.02985768,0.051040158,0.11085766,0.048395112,0.11491913,0.038212497,-0.02457552,0.058462113,-0.014353656,-0.05642476,0.100380376,-0.03652468,-0.08842311,0.014380842,0.087712,0.048707206,0.016695486,0.07382841,0.046414036,0.0051567587,0.051669173,-0.096572205,4.4410893e-33,0.07334061,0.10448672,0.0006224431,0.012862488,0.009341157,-0.06152346,-0.1092468,0.021281086,-0.020361625,-0.042652432,-0.036057845,-0.007423346,0.08591223,-0.023157468,-0.05948873,-0.022766538,-0.038556263,-0.032588992,0.023508877,0.024703776,-0.024888739,0.029708512,-0.07010057,0.05713683,0.011236328,-0.02269197,-0.030432852,0.057956792,0.043282196,0.03804615,-6.0425533e-05,-0.08371457,-0.023212673,0.008860321,0.08362892,-0.04096195,0.0022823308,-0.05428934,-0.01944847,-0.011798935,0.11416407,0.021910794,0.02322051,-0.0051290803,0.05666175,-0.008647457,0.011981607,0.13148819,0.070502385,0.023160059,-0.03029923,-0.019385504,0.04766153,-0.015386638,-0.069222465,0.018695772,-0.01449607,-0.050375015,0.101469986,0.020217806,-0.06532843,0.016886486,-0.012796368,0.062474873,-0.037692983,0.01985931,-0.0214417,-0.007329134,0.039516248,0.10370051,-0.06065216,-0.012267976,-0.010072877,0.086914614,0.009871617,-0.040423036,0.068272725,-0.07387577,0.09356609,-0.008355251,0.045341823,0.019276546,0.028450409,-0.0009475995,-0.030710608,-0.045915,-0.043660298,0.017706176,0.050300173,0.060386322,0.027928999,-0.052482564,-0.036275577,0.033520266,-0.01635404,-4.8197083e-33,0.057177104,-0.047236547,0.0056540286,-0.1482409,-0.08700543,0.06490387,0.018492818,-0.04534651,0.09223836,-0.0057088085,0.11810584,-0.031817473,0.09088574,-0.052144703,0.023214448,-0.042943105,0.053340126,0.06708628,0.028224576,0.013956872,0.030132432,0.038329687,-0.024307046,-0.057754833,-0.024599941,0.041086834,-0.025916453,0.020125221,0.054600343,0.05126905,-0.029004354,-0.035580393,-0.06899992,-0.0023157676,-0.1200713,0.00460502,-0.0726937,-0.00035868722,0.012415034,0.017830636,0.02626281,0.07682048,-0.016468218,0.023074552,0.05964675,0.0019112823,-0.07989354,-0.038550153,0.00955464,-0.0813526,0.03191909,-0.018271875,-0.06550602,-0.053573564,-0.03500792,0.050532047,0.017403696,0.052038092,0.02513137,-0.00015030713,-0.059653725,-0.01988818,0.04802892,-0.028741391,0.058534216,0.04178699,-0.037202038,0.07128131,0.06450649,0.01766008,0.018300945,0.10836231,0.045895826,0.011732418,-0.010277819,-0.0355169,-0.08552085,0.022901805,-0.037553903,-0.028258735,0.011355959,0.036364164,0.09297565,-0.05505349,-0.08691348,-0.08813932,0.0101849465,0.06836924,0.031536963,-0.0024481614,-0.06848405,-0.0256987,-0.06732917,0.034825698,0.0040833866,-3.8696218e-08,-0.02248976,0.054467414,0.082902774,-0.01109573,-0.027815897,0.08163631,0.07730227,-0.07096113,0.06419976,-0.025903473,0.003224395,0.056281984,0.052238595,0.020190917,-0.02387204,0.04594549,-0.06049361,-0.03741283,-0.022224072,0.01647468,-0.002022079,-0.014597236,0.0022554263,0.023053078,-0.03951553,-0.045511603,0.054149527,0.040196016,-0.062303238,-0.06826652,-0.07840117,0.014714626,-0.049361512,-0.013147751,-0.0994811,0.010068428,-0.00075766386,-0.016857374,-0.06284761,0.03564329,0.00038043328,-0.024608783,-0.097183265,0.055656683,0.04084214,-0.0497628,-0.0021112966,0.06288564,-0.0021515703,-0.009901066,0.052044597,-0.022908477,-0.022009468,-0.054451797,-0.040205084,-0.07054962,0.013816538,-0.031230152,-0.036134724,-0.016338237,0.07300014,-0.00671125,0.14562868,-0.04397875 +6.4.1.9,"The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.",384,1.0,-0.08654975,-0.0073409583,-0.120982304,-0.03539759,0.07185132,0.016908064,-0.104108274,-0.03051049,-0.052744363,-0.0064937123,-0.0005879918,-0.09789816,-0.033299446,-0.0242697,-0.048822954,0.026011549,-0.09133218,-0.018458687,0.036240965,-0.051835958,0.042566992,0.032062575,-0.026684904,-0.023279568,-0.04330819,0.032311313,-0.034288466,-0.08266559,-0.00927033,-0.043378636,-0.039926168,-0.025505109,0.024191957,-0.07624937,0.091721475,0.059966315,-0.018001804,-0.027806193,0.030819302,0.01419859,0.009096544,0.03901566,0.050448738,-0.046991874,-0.0033917562,-0.02658425,0.055948738,0.0007274549,0.012201615,-0.08239152,-0.075211346,-0.027792277,-0.04865412,0.0050972574,0.087689005,0.054102354,0.01975401,-0.058633503,0.0062701968,-0.027612878,0.10277087,0.019281521,0.0056248484,-0.010073833,0.015006914,-0.0038546273,0.049361877,-0.08970049,0.09140835,-0.004824603,-0.09069892,0.00012405304,-0.06869609,-0.021432286,-0.030081403,0.013706851,0.0066461507,-0.07665889,0.06487338,0.00840827,-0.008495268,-0.014232733,0.023587016,-0.014881959,0.061724834,-0.06652633,-0.015148751,-0.026103416,0.050953437,-0.0011852675,0.021038303,-0.0277712,-0.048175473,-0.013153504,-0.1228476,0.03573233,0.024149856,0.09551061,-0.008785413,0.0017908724,0.038857374,0.04445962,-0.033525288,-0.05695296,-0.050626397,-0.01857325,0.049053557,0.12500633,0.052265942,0.11202971,0.031906605,-0.029127324,0.06224183,-0.012329758,-0.053753536,0.10881837,-0.030696144,-0.07113523,0.021004995,0.08555766,0.061991274,0.02209571,0.06048307,0.042644892,-0.008197444,0.05388945,-0.09284669,5.095469e-33,0.07228489,0.1104794,0.0024494745,0.007964711,0.0008160353,-0.056859646,-0.10460254,0.01970007,-0.027509252,-0.029927896,-0.0332977,-0.0049498454,0.075069785,-0.03566799,-0.08083147,-0.042093977,-0.038632333,-0.023288157,0.017756933,0.027158314,-0.016736625,0.03798845,-0.057775944,0.055859804,0.012406947,-0.014154413,-0.025269158,0.047400594,0.04598744,0.040277034,-0.00022675721,-0.08503139,-0.023993412,0.00046498294,0.077757925,-0.04865438,0.00030097738,-0.04706186,-0.014815454,-0.0018561637,0.1147926,0.020359604,0.017877473,0.0015090957,0.050877754,0.0056379214,0.012510225,0.13633148,0.07331998,0.020691495,-0.02909962,-0.025913782,0.038837735,-0.012891396,-0.07803402,0.021356769,-0.011724344,-0.042031743,0.09997008,0.022146221,-0.0514758,0.023548212,-0.008327965,0.054386586,-0.04282726,0.005921058,-0.01974042,-0.0003762259,0.036788553,0.0954719,-0.059416365,-0.004548962,-0.0011829422,0.08186034,0.021208035,-0.043956537,0.073187485,-0.089108415,0.09921185,-0.015873289,0.033013176,0.040757213,0.013548714,0.0070382725,-0.02095231,-0.037870146,-0.056411896,0.017786298,0.050060987,0.08056959,0.001257409,-0.053978182,-0.039088823,0.024593847,-0.020052861,-5.034327e-33,0.061038088,-0.05124054,-0.0024641994,-0.14901134,-0.089080274,0.0473281,0.018698256,-0.0590587,0.10245939,0.0025053557,0.11675805,-0.04128029,0.102600105,-0.043169238,0.023065936,-0.030474838,0.058347132,0.06924368,0.028119702,0.007853217,0.03429262,0.034432504,-0.036971204,-0.05825125,-0.0249532,0.04339525,-0.015926706,0.017874634,0.06714384,0.05372236,-0.027687248,-0.05505905,-0.06240352,0.006648775,-0.11247542,0.0257378,-0.070848964,0.0014557852,0.026717875,0.014209878,0.029104983,0.0709659,-0.021461464,0.014877911,0.0697695,-0.011217704,-0.088579185,-0.028303938,0.005798936,-0.073613964,0.05102801,-0.014066724,-0.07419823,-0.05595287,-0.040688764,0.053190533,0.027382012,0.045215104,0.021419697,-0.0017677131,-0.061456196,-0.022271212,0.0519009,-0.025412222,0.06442871,0.052124348,-0.039615545,0.078790106,0.04511856,0.012635973,0.007967694,0.10383441,0.038799245,0.0035529216,0.0077475714,-0.0329407,-0.071706235,0.014297433,-0.03457427,-0.036185797,0.01388899,0.03247872,0.09955345,-0.051354717,-0.076986186,-0.084538504,0.013387795,0.06720407,0.03544304,-0.005206449,-0.06787606,-0.031178802,-0.04555117,0.035959028,0.0067400467,-3.9449557e-08,-0.029438,0.048729442,0.08367597,0.00036438537,-0.010532366,0.098101616,0.08131301,-0.077693865,0.060989507,-0.026071217,0.008466682,0.048338816,0.058232978,0.018869292,-0.030298304,0.046112534,-0.06355047,-0.048467338,-0.017960846,0.014231308,-0.0047565335,-0.009844692,0.002152498,0.0048841303,-0.040050283,-0.038239624,0.052557636,0.024599211,-0.06403176,-0.077913426,-0.07948905,0.021522649,-0.06922681,-0.0042543383,-0.08677223,0.0014138966,-0.004910959,-0.012094312,-0.06205338,0.032978643,-0.016537424,-0.031866167,-0.08493294,0.05763094,0.02924171,-0.04710657,-0.014891707,0.062659256,-0.0076789414,-0.000566773,0.050218847,-0.032524746,-0.017868359,-0.051502075,-0.03841818,-0.06999305,0.013628466,-0.030378716,-0.048123144,-0.015401065,0.064523645,0.0015716249,0.13518016,-0.0489326 +1.1.1.413,"The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.",384,1.0,-0.08855422,-0.05245435,-0.024840623,-0.060617264,0.037851904,0.1146055,-0.07720747,0.012349114,-0.010779734,-0.020594716,0.050800253,-0.08656802,-0.050375137,0.03939904,-0.07322018,0.07034443,-0.014108695,-0.0064229253,-0.0017125226,0.0040650405,0.026242426,0.04972622,-0.04311729,0.04317812,0.020420795,0.022587901,-0.00028380583,0.021992128,0.024676213,-0.12295704,-0.004902061,-0.031105207,-0.051370997,-0.0051998105,0.050680626,0.03598053,-0.04716691,-0.042426176,0.026224257,-0.016133511,0.0013893471,-0.042516746,-0.0016889822,-0.002807872,-0.02596247,0.0104993,0.070527226,-0.0074313334,0.066840574,-0.078851074,-0.012466265,-0.061101604,-0.050540145,0.0411535,-0.039908163,0.05145017,-0.027647806,-0.02161128,0.003752027,0.006382436,0.051297173,0.04843126,-0.0039406857,0.011716605,-0.0101250615,0.014405196,0.006806103,0.0068973857,-0.0072016655,-0.039192535,-0.039801516,-0.04205188,-0.061253313,0.12607817,-0.017405963,0.025655279,-0.027092446,-0.021126458,0.15448941,-0.04182479,-0.021114979,0.021746919,-0.0025438776,0.15774794,0.033019755,-0.046173744,0.007737397,-0.0027150677,0.113286905,0.0143192,-0.0046987454,-0.00073500583,0.040328696,-0.03259569,0.006338844,0.023313845,0.0371297,-0.0038008422,0.09923852,-0.0048906696,-0.035946026,-0.014332915,-0.044214595,-0.042689778,-0.026442284,0.0068964083,0.036949717,0.070185244,0.048527483,-0.025119357,-0.0038426009,0.05809703,0.023575302,-0.013934199,-0.031203283,0.03737312,0.10737614,-0.016991181,-0.09979366,-0.07034466,-0.03591791,-0.0005889977,0.047992982,0.043823738,-0.050238676,0.007066554,-0.084818065,3.9505096e-34,0.019611312,-0.0019037381,-0.0026293176,-0.049600318,0.019194493,0.03382474,-0.076651804,-0.030385444,-0.06817755,-0.097942874,-0.094328806,-0.0902664,0.0035474054,0.08388792,-0.032897234,-0.069163084,-0.02057131,0.03831881,-0.051786747,-0.04303958,-0.05087273,0.06311678,-0.008608914,-0.023228599,-0.06619918,0.01884121,-0.021016676,0.0591138,0.007998443,0.0034919463,0.008700417,-0.066483594,-0.087485835,0.04739025,0.043563474,0.08101647,-0.03384543,-0.06134593,-0.0001446099,0.08465609,0.021214,0.1055332,-0.11963114,-0.06185908,0.05316871,-0.052766692,-0.0237365,0.103800856,0.012406361,-0.012517732,-0.0011509812,-0.035459265,0.038249094,-0.080347426,0.004082874,0.08174444,0.019832835,0.09099199,0.0088291755,0.03788955,-0.0002497364,0.093856625,0.0051651555,0.072725296,0.0056403265,-0.007591147,-0.013027313,-0.080745585,0.0021318994,0.005212554,-0.03384682,0.030108456,0.05374688,-0.04046302,0.04879596,-0.07823102,-0.051186197,0.012200388,0.029392952,-0.042201325,-0.06500881,-0.08424067,0.035195556,-0.03659076,-0.061611854,0.01325871,0.029937139,-0.06275758,-0.0053639393,0.04711422,0.060000133,-0.08022291,-0.009135507,0.007361057,-0.0015332587,-1.1069812e-33,0.013134297,-0.053833723,0.041606475,-0.032831278,-0.026694382,0.081393495,0.07945017,-0.062395047,-0.0012964242,-0.02693438,0.06768896,0.051629204,-0.033279344,-0.011215995,0.022507468,0.04905924,0.048922073,0.033256635,-0.00783284,-0.059392832,0.011337326,0.07829574,0.012670179,0.033237677,0.0024792955,-0.030834856,-0.049634833,0.07300164,0.047608808,0.066465795,-0.0064309957,0.028165003,-0.04164986,-0.096008934,0.055442024,0.030796496,-0.025302675,0.026915329,0.0099826185,-0.042478185,-0.01895401,0.03677302,-0.04161108,0.03631751,0.01447502,0.14465953,-0.04412949,0.012713434,0.021965528,0.012559898,-0.007037778,-0.07544494,0.019217514,0.0785686,-0.04143828,0.016731651,0.030158456,0.03823625,-0.015020027,-0.02845088,-0.03127875,-0.060907725,0.056639478,-0.06591573,0.034812063,0.07237848,-0.019336347,0.029119058,0.034836825,-0.06670258,0.08170588,-0.023197342,0.013749131,-0.0028465209,-0.03851939,-0.015847044,-0.03759779,-0.05130064,-0.055727888,-0.04180344,-0.014162492,0.026790235,-0.019150324,-0.08190263,-0.04633305,0.0034314047,-0.03714494,0.10746153,0.03259961,0.11926742,-0.045185592,-0.029895497,-0.062130317,0.07066935,0.07128456,-3.8118966e-08,0.04061707,-0.033538915,0.060659327,-0.0058192117,0.0033479382,0.011252106,0.024025818,0.06290108,0.14535426,-0.0021030952,-0.028000912,0.053886194,0.05594225,0.035304394,0.032245427,0.038943544,0.01893704,0.048786532,-0.04834553,-0.019868234,-0.04852617,-0.032738365,0.024675649,0.019355258,-0.0051041073,-0.085905254,0.0012651876,0.03802573,-0.008495151,-0.07820317,0.04295436,0.118116654,-0.025057742,-0.020257588,-0.096655965,0.082301944,-0.053255334,-0.005001757,0.039015975,0.05055358,-0.05749502,-0.045010395,-0.029562883,0.00011070226,0.06646888,0.054701317,-0.027002448,0.03072776,-0.02766942,0.0140903685,0.029746607,-0.0015024698,0.009897894,-0.04064274,-0.12607533,0.045535196,0.017176475,-0.03392861,0.010377158,-0.092465736,-0.023697732,-0.010034193,0.19702227,-0.07725737 +1.1.99.41,"This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle). In vivo, it functions in the direction of reduction. It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates.",384,0.99999994,-0.061781347,0.031569712,-0.12278411,-0.05774901,0.027084695,0.081156574,-0.11474202,0.05697305,0.037895206,-0.0031135778,0.025935942,0.026235653,-0.03828347,-0.041882165,-0.07827845,0.083183035,-0.11726583,0.08993058,-0.010468456,-0.024340501,0.042902935,0.01724605,-0.0067776195,0.022906499,0.047271844,0.017177679,-0.0015829488,0.016084783,-0.03894278,-0.060975354,-0.016170122,0.034233943,-0.016341425,-0.059082743,-0.030461773,0.0875955,-0.04332009,-0.012960788,0.042373504,0.06970295,0.008536102,-0.025792075,-0.08075761,-0.03591055,0.022361372,-0.008498271,0.008078727,0.016072672,0.05671183,-0.07243198,-0.026571164,-0.008426517,-0.01562074,-0.02170661,-0.04490062,-0.052588463,0.01542824,0.04524899,-0.040703222,0.013491137,0.078425564,-0.0018746698,-0.015983116,0.036666874,0.011642655,-0.0468414,0.0030969759,0.0007946,0.019169765,-0.102285765,-0.006795264,-0.047606345,0.005512252,-0.032792255,-0.043704316,0.068075396,-0.02606334,0.021610813,0.05017755,0.022913562,0.019187955,0.033091605,-0.022703283,0.07063131,0.022408877,0.07378726,-0.0010289728,0.0029476732,0.03702041,0.03943201,0.018186808,0.010289403,-0.02889955,-0.0007809105,-0.062073093,0.031071069,0.049174868,-0.05615494,-0.011547538,-0.01299854,0.014842513,0.03258402,-0.06451711,-0.08333038,-0.068422936,0.059044812,-0.010495835,0.06572828,0.027958086,-0.02003463,-0.024342438,-0.00061896135,-0.013142154,0.008371915,-0.018042425,0.14496721,0.054101504,-0.023516003,-0.03608943,-0.007388441,-0.03169784,-0.010579595,0.0034805636,0.025123397,-0.025403399,-0.03875485,-0.005096092,1.5991111e-33,0.052721273,0.06254101,-0.0550104,-0.04911559,0.04326952,0.013745865,-0.1549454,0.011948449,-0.06744948,-0.05341075,-0.110612355,-0.10220629,0.015447104,-5.882901e-05,-0.020241942,-0.013287604,0.025815012,-0.031466838,0.026674462,-0.015412098,0.033356383,0.007333239,-0.042581797,0.00049159804,-0.012673605,0.06824245,0.0039873077,-0.033068046,-0.030005677,-0.010294518,0.023607284,-0.14186436,-0.05978634,0.0096221985,0.0005669892,-0.025558863,-0.06659075,-0.06277311,0.018387716,0.082256876,-0.03265122,0.040913925,0.0119588515,-0.014584344,0.04616407,-0.06822677,0.0036902374,0.16914578,0.014520186,0.052541476,-0.0027706085,0.045727633,0.12728669,-0.011275688,-0.06305487,0.0036975753,0.01647305,-0.0064805155,0.006253547,0.02153234,0.06647807,0.004500225,0.0002840001,0.016632725,0.025191756,0.03153299,-0.07746779,0.021626847,0.060455523,0.040794164,-0.06658153,-0.0044346396,-0.037386805,-0.025518456,0.07708921,-0.04951482,-0.043696858,0.020148573,0.032420445,0.0051132143,-0.047853295,-0.03216298,-0.020708822,-0.015738063,0.012460252,0.030322293,0.010261457,-0.009299279,-0.027486991,0.064085275,0.050335407,-0.03891265,-0.04314325,0.0007769089,0.11417269,-2.0760624e-33,0.03908877,-0.051323447,0.029819164,-0.055630434,-0.03555675,0.065802395,-0.04969362,0.029906537,-0.03251726,-0.028802047,0.014008086,-0.017977666,0.052672327,0.005248364,-0.026231764,0.038165353,0.009715328,0.091699965,0.016694695,-0.029644901,-0.056872334,0.055261753,-0.017425034,0.038980436,0.014948827,-0.048057314,-0.021821419,-0.012462294,0.021421192,0.0601465,0.020921944,-0.008727536,-0.07964345,0.026692517,0.01379037,0.08875556,-0.028074278,0.06682425,0.045691755,0.053943068,0.061600044,0.0013555052,-0.04295861,0.03864315,-0.004435324,0.026464168,-0.12806673,0.07492135,-0.019268807,-0.04518506,0.03226419,0.0952398,0.08078056,0.054218236,0.07450095,0.027889412,0.042970877,-0.028570589,-0.031198641,-0.036791306,-0.040982686,-0.105464354,-0.019913962,-0.0076632327,0.027952552,0.08347765,0.00042666818,0.056573093,0.061885122,-0.046426684,0.10524271,-0.018484812,-0.015280852,0.070059285,-0.034826465,-0.017030226,-0.023331013,-0.07472806,-0.0017436072,-0.03870599,0.018827906,-0.02120774,0.014422752,-0.122388415,-0.062425982,-0.015982881,-0.004414926,0.09480532,-0.019616818,0.03625774,0.05156541,0.07396485,-0.068926245,0.004946216,0.08866071,-3.5026137e-08,0.055398203,-0.066571325,0.08765609,-0.027610803,-0.02986737,-0.008669476,0.060195938,0.048976667,0.010800417,-0.030918716,-0.01236536,0.08722769,0.043166522,0.022059249,0.09676742,0.017526522,0.10571614,0.050696235,-0.027986182,0.014397101,-0.06792861,-0.011110139,-0.099670775,-0.05143391,-0.00039737523,-0.08615692,0.05393637,0.037765373,0.014190602,-0.035884783,0.037582226,0.01864962,-0.010800465,-0.10319106,-0.098497614,0.0943869,0.004861666,-0.0553043,-0.003377395,-0.056601577,-0.020925969,-0.056215193,-0.0070237718,-0.01521153,-0.020207107,-0.010091115,0.08852956,0.0080936905,0.006217285,-0.028640304,0.008267315,-0.0036780366,0.08608415,-0.094508916,-0.1463527,0.049799785,0.018838327,-0.054503907,0.0042386996,-0.09665357,-0.023082705,0.009817765,0.17429371,-0.08776279 +1.5.5.3,"A flavoprotein (FAD). The enzyme from human also has low activity with L-proline (cf. EC 1.5.5.2, proline dehydrogenase).",384,1.0,-0.0530563,-0.10556275,-0.100362256,0.011143605,0.104269646,0.027354907,-0.017020175,0.12726219,0.03732507,-0.012193758,0.029387692,0.022453682,-0.09400976,-0.018054347,-0.050657537,0.03389894,-0.043651234,-0.06800931,-0.06671116,-0.031385094,-0.014189578,0.021341192,0.041992404,-0.022733524,0.009208525,-0.055994287,0.029883914,-0.04190106,-0.020903194,-0.0026839313,0.080706574,0.017720526,0.08273424,-0.0011898809,-0.0054724114,0.059252508,0.039375085,-0.04021463,-0.024421144,0.03363429,0.04229035,-0.036923666,-0.02695685,-0.022672696,0.05343003,0.010516197,-0.063565806,0.011887662,-0.013995438,0.063920975,-0.021064155,-0.020326596,-0.0969927,0.019145278,-0.04942699,0.020328103,-0.018891096,-0.04123223,-0.031331733,0.023744432,-0.031865068,-0.02342908,0.06403496,0.01304339,0.093803905,-0.055712294,-0.039131414,-0.022232762,0.047407497,-0.031141473,0.0022002168,-0.04375427,-0.059527185,0.08582849,0.016571643,-0.0072043403,-0.080163725,-0.052945636,0.03899011,-0.04067909,0.083500594,-0.011695225,0.020265028,0.07060389,0.02618028,-0.025935221,0.01363888,0.009537068,-0.0632086,0.06230919,-0.0075440616,0.033183146,-0.028601531,0.057231713,-0.075462475,0.08257953,0.022722693,-0.064249836,-0.1291359,-0.013871094,-0.07283212,0.02294629,0.034678273,-0.010074916,-0.049547203,-0.0050549796,0.0051325685,0.060029548,-0.05794522,-0.045296364,0.050990805,-0.058032602,0.008454873,-0.018659024,0.01756491,-0.010826748,-0.03200042,-0.09357044,0.0048973216,-0.0055912137,-0.03529972,0.07019362,0.06557304,0.0936057,0.022957282,0.06827956,-0.065416835,-1.8001242e-34,0.08932408,-0.037201546,0.0071318047,-0.014821613,0.0027788382,0.010284652,-0.092510894,0.009598822,0.045506705,-0.010474091,-0.03792409,-0.03797803,0.023251597,-0.025901895,0.056413084,0.005453525,0.02173306,-0.057867736,0.061167087,-0.045661796,0.014263429,0.026005525,0.00024519456,0.03503248,0.048621282,-0.01794823,-0.039525434,0.030058062,-0.009028162,0.017263746,-0.050479434,-0.10034539,-0.0019652138,0.0014392764,-0.03896304,0.058687124,-0.058146544,-0.08349918,-0.091677874,0.088107295,0.01651535,-0.0012534745,0.013667473,-0.026519272,0.039740536,-0.063822165,-0.03957345,0.08018649,-0.07366276,0.09421711,0.038752202,-0.0025133824,0.09144526,0.014218979,-0.07322236,0.009814249,-0.04461528,0.026552634,0.008385769,0.040202554,0.028492741,0.07671787,-0.04698358,0.10602255,-0.034268077,-0.018575333,-0.045913924,-0.06441767,-0.03278592,0.10254155,0.016621213,-0.02968888,0.14534028,-0.022589881,0.08906405,-0.01745663,-0.0306229,-0.02404733,-0.021843677,0.0058341115,-0.020253045,0.004211629,-0.021108437,0.013969194,-0.03247963,0.02562516,-0.038123284,-0.030813245,0.0062889033,-0.02162311,0.0070900787,-0.057971537,-0.040871505,0.05056432,0.0395489,-4.133813e-34,0.007082483,-0.09998037,0.06458924,0.018603541,0.018174747,0.08196613,0.07504228,-0.04932284,0.051694494,0.018387074,0.07614642,-0.09278771,-0.009481482,-0.03291725,0.089840144,0.049894907,-0.08783499,0.038518216,0.08633805,0.02795238,-0.026860703,0.036699746,0.04629415,0.09763129,0.042667285,-0.009617199,0.017465318,-0.031915363,-0.017849216,0.0030288375,-0.01135435,0.058523063,-0.06531261,-0.078278944,-0.074589945,0.039868824,-0.04470956,0.012540798,-0.021906056,0.011633771,-0.027088968,0.07499359,0.03585747,-0.0010758531,0.014013993,0.049195815,-0.04426884,-0.011818969,0.035347402,-0.007798814,0.0039158934,-0.0003081649,0.008800156,0.07598107,0.0387179,0.048570365,0.025513828,0.06275333,-0.016782567,0.013732282,0.025168216,-0.1153133,-0.012989158,0.042564973,0.08601128,0.048637655,0.027199533,0.09710928,0.016755579,0.005817744,0.16015032,-0.015601551,-0.003383661,0.040504284,-0.00023528126,-0.008630666,-0.034543537,0.06034603,0.020867217,0.0009092589,0.028784722,-0.019554542,-0.023182422,-0.014578909,-0.07300938,-0.08673428,-0.05054305,0.07007605,0.035005134,0.09278827,-0.05915662,0.0332329,-0.070763305,-0.053408243,0.025860282,-3.0527175e-08,0.025367737,-0.028048672,0.04449181,-0.017497918,0.11166588,0.011512867,-0.011902756,-0.008525251,0.036662545,-0.013226908,-0.08292571,0.089650996,-0.04515865,-0.038652062,0.079980046,-0.004081589,-0.0043046074,0.060329925,-0.02188272,-0.0050938376,-0.03937947,0.01991375,-0.10273059,0.023377085,-0.06326507,-0.06462957,0.027116772,0.008361577,0.038100213,-0.050512955,-0.002412706,0.041937944,0.047972336,-0.07789206,-0.07700095,0.047442917,0.07983733,-0.041331343,-0.102511436,0.087956935,-0.09322966,-0.033377606,-0.004917013,-0.072611615,-0.008338379,-0.036703642,0.05192643,-0.007887666,-0.017377272,-0.036020637,-0.0044630463,-0.041881487,-0.009519028,-0.01585942,-0.09042108,0.030219415,-0.015349051,-0.07841554,-0.043626647,-0.124531746,0.050679043,0.049643643,0.1309089,0.010648474 +1.5.98.3,"The enzyme, found in some methanogenic archaea, is responsible for the reoxidation of coenzyme F420, which is reduced during methanogenesis, and for the reduction of methanophenazine to dihydromethanophenazine, which is required by EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase. The enzyme is membrane-bound, and is coupled to proton translocation across the cytoplasmic membrane, generating a proton motive force that is used for ATP generation.",384,1.0,-0.047420874,0.069045015,-0.052927498,-0.009917441,0.04746557,-0.008443462,-0.05768315,0.042631723,-0.023649996,-0.0055730282,-0.03773452,-0.026501568,-0.01359405,0.0089035,-0.066623986,0.02227179,-0.041393097,0.011439723,-0.047695745,-0.056694847,0.061614417,0.017267795,-0.013482232,-0.0454098,-0.04555869,-0.014437809,0.052874606,0.0036292244,-0.017011324,-0.029527446,0.036547653,-0.04208515,0.03601998,-0.028567834,0.018461764,0.12066341,-0.05611602,-0.07328749,0.03133744,0.0057061305,-0.00045322106,0.06086804,0.01190748,0.04643807,-0.021243313,-0.016611379,0.018202294,0.026544277,0.015969655,-0.0635242,-0.019140886,-0.045123514,-0.06334553,0.06506962,0.077276215,0.06812733,0.0046473523,-0.020853674,-0.03365654,-0.037944864,0.04308609,0.016810397,-0.01713195,-0.030865645,0.01649724,-0.010122852,0.055659335,-0.06882003,0.10215356,-0.029902637,-0.017613398,-0.0063003367,-0.042194176,-0.047558215,-0.034820586,-0.018219715,-0.024272006,-0.04200107,0.030970294,-0.0023873437,0.048314717,-0.04108168,0.042197682,-0.011542623,0.10467264,-0.04371822,-0.045312937,-0.08750478,0.058410916,-0.01318209,-0.0038624965,-0.012971335,0.00260501,0.009497962,-0.13164063,0.02721859,0.059856545,0.015145445,-0.0161287,0.028376518,0.0010367278,0.052017666,-0.05766641,-0.015847648,-0.080238014,-0.02284616,0.07343799,0.12983738,-0.03861127,0.036030382,0.022499269,-0.010471895,0.11804444,0.036197867,0.025887717,0.09850128,0.01291922,-0.07531062,-0.021478081,0.031960588,-0.013083706,-0.01290779,0.06709689,0.0166027,-0.044600613,0.045194265,-0.13986793,4.7618534e-33,0.043078896,0.017244296,0.011991815,0.025730243,0.0017023771,-0.009064971,-0.089098096,0.030611692,0.00039324118,-0.043383628,-0.08409953,-0.07984738,0.08176993,-0.057639837,-0.066681474,-0.06717136,-0.050585534,0.018729523,0.025802398,0.059013106,-0.020225292,-0.006810246,-0.0075261034,-0.024973555,0.07371913,0.02566062,-0.018119507,0.022927258,0.07943986,0.015791865,-0.009335778,-0.09282084,-0.10938672,-0.013168911,0.011485714,0.04740826,-0.11128616,0.01334511,-0.06578454,0.041285213,-0.015764358,0.0048623583,-0.0343929,-0.05613386,0.10098039,-0.034874715,-0.05466946,0.14083111,0.031037467,0.049027212,0.025006428,-0.027464246,0.06829729,-0.018942779,-0.08625836,-0.028569575,-0.0039344295,-0.048588045,0.05756679,0.0863802,0.058335762,0.042452894,-0.06369123,0.111682996,0.05508633,0.074008964,-0.0033033977,-0.025855308,0.010655491,0.12045736,-0.039897554,-0.04414847,0.022173842,0.04914128,0.011907193,-0.037356213,-0.015931444,-0.023225026,0.029889569,0.014383032,0.05549026,-0.037700176,-0.008804849,-0.04163266,-0.025000235,-0.008358703,-0.030127335,-0.0486098,0.0674225,0.004235645,0.12421483,-0.093920074,-0.0058023618,-0.011291143,0.020878164,-3.9271257e-33,0.067816414,-0.059468735,-0.025227781,-0.12238999,0.019910343,0.07149637,0.0025938621,-0.052899793,0.035636365,-0.03592544,0.107221596,-0.041672476,-0.021621788,-0.020943139,0.021936165,-0.018987557,-0.041791316,0.026293572,0.021782838,0.026314966,0.03966461,0.06658857,-0.019505825,-0.017809568,0.012300718,-0.014761392,-0.041176878,0.052458666,0.078188024,0.032417357,-0.04653626,0.003798691,-0.060406905,-0.015979381,-0.0748121,0.06500512,-0.116759144,0.021430098,0.02007924,0.0009317328,0.03598943,0.09816491,-0.00154322,0.058477588,0.042691458,0.10046201,-0.12382751,-0.013215177,0.06783879,-0.08221585,0.021961994,-0.04671595,-0.052011702,-0.019361876,0.0038601784,0.06177489,-0.007466662,0.024753088,0.009161008,0.023138069,-0.021863693,-0.06994774,0.046056107,0.034653757,0.035872027,0.01682724,-0.0046303817,0.11364776,0.0013210466,0.03672359,0.010682601,0.05131416,0.01616927,0.08741105,-0.03217782,-0.018871449,-0.06741714,0.04587848,-0.03815888,0.013181927,-0.009514672,0.016694881,-0.0011708996,-0.03764288,-0.028332647,-0.14402759,-0.026119286,0.04242206,0.011783123,0.026961861,-0.047539115,-0.04847793,-0.02916037,0.052774295,0.04512975,-4.2129106e-08,0.030684741,-0.023041839,0.031610247,-0.030042691,0.010218248,0.07279531,0.06283828,-0.00907652,0.03011134,-0.042490486,-0.02032876,0.10059283,0.039748654,0.026568966,-0.023602773,0.07123241,-0.058018237,0.009893505,-0.010399003,-0.010831546,-0.010242254,-0.04566099,-0.084747136,0.061014842,0.03446468,-0.07241525,0.062681556,0.08230128,-0.04162962,-0.12653239,-0.016484393,0.036274336,0.040855795,-0.0011033205,-0.09386613,0.026291227,-0.043260686,0.040299166,-0.08179279,0.02686935,0.0053056567,0.0047291354,-0.067781866,-0.001208243,0.08482638,-0.005187408,0.0043265694,0.011998261,-0.027221859,0.0071999175,0.016954755,-0.0019122642,0.04846805,-0.061528254,-0.07526703,0.008454866,-0.03928839,0.0013650038,-0.07043573,-0.06883898,0.0896591,0.002988417,0.15029654,-0.039257567 +1.8.1.20,"The enzyme, characterized from the bacterium Rhodococcus erythropolis MI2, contains an FMN cofator.",384,0.99999994,-0.061765485,-0.0555736,-0.107549176,0.039158925,0.049508173,0.0077689476,-0.062894575,0.087431535,-0.008209497,-0.05758222,0.055817224,-0.066382214,-0.06963535,0.10195903,-0.05701296,-0.032642435,-0.02791125,-0.039659455,-0.00427005,0.0005046718,0.07515227,0.03348731,-0.026872454,-0.017647054,-0.0341852,-0.025017703,0.055120617,-0.049284652,-0.037761938,-0.032694187,0.037851464,-0.0830249,0.12328902,-0.033285,0.089399286,0.03536421,0.066048145,-0.08582841,0.07424291,-0.004540231,-0.03433132,-0.023237452,0.07518921,-0.03649591,-0.012982811,0.020727644,0.011403146,0.026151175,0.025747504,0.021238737,-0.045758717,-0.045449,-0.108224384,0.062858425,0.092253745,0.044480223,-0.05846165,-0.044862255,-0.0837331,0.04207601,0.045061044,0.043144118,0.019624157,-0.008144682,0.024720205,-0.024236346,-0.0071846945,-0.07295033,0.034014367,0.029961532,-0.008561865,-0.040342286,-0.0445037,-0.04691029,0.02310976,0.070541255,0.0018396216,0.04592208,0.06786316,-0.03122309,0.017521191,0.061665356,0.02116368,0.04139147,0.027302917,-0.008716074,-0.00315073,0.026966525,-0.020950435,0.051243566,0.029377395,0.019978968,-0.019170828,-0.06967606,-0.07905868,0.03266874,-0.00334689,0.08963419,0.031194847,-0.02308211,-0.02473416,0.05528412,0.03364372,-0.08323723,-0.079436556,-0.064763196,0.0010645577,0.10288851,0.122524485,-0.039792728,0.013621675,0.032880988,-0.011922731,-0.023052257,-0.008412448,0.0923911,-0.0011170127,-0.037800934,-0.06584651,0.0721056,0.029481351,-0.0417916,-0.016520916,0.052555587,-0.030128717,-0.0052184532,-0.18459147,1.367871e-33,0.0042819697,0.0025955676,0.024887903,-0.037006825,-0.058030948,-0.016972834,0.005811119,0.015978934,-0.0026982417,-0.06303746,-0.080616824,-0.016234899,0.024902496,0.030099707,-0.090796836,-0.024927964,-0.03101016,0.02226268,0.047417916,0.027996834,0.07792732,0.07115738,-0.0070284447,-0.052941196,0.032441564,0.05418602,-0.054086182,-0.028320597,0.05043253,0.0069652265,0.011776918,-0.14674273,-0.03764094,0.045609284,0.064579405,-0.036155667,-0.048971213,-0.035645153,-0.06257731,-0.0051034247,0.01626255,0.034875702,-0.06380395,0.010850952,0.08320205,-0.03275962,-0.06726052,0.015794244,0.012274602,0.053724363,0.008238008,-0.0078061568,0.030020062,0.027737057,0.007319858,-0.0135284625,0.0077463076,0.06397368,0.02382343,0.01233963,-0.011689268,0.13391973,-0.012319229,0.057418846,0.07799112,0.046941366,-0.013871665,-0.057967033,0.027272612,0.15503131,0.029932113,-0.016444005,0.028286798,0.035755474,0.010650575,-0.0766714,0.0060155834,-0.019901391,-0.00970393,-0.0058959937,-0.030198583,-0.002377896,0.024215382,-0.018660702,-0.098579094,0.00045268482,-0.0025715819,-0.008173412,-0.047003746,0.056790415,0.101756275,-0.04697481,-0.05749021,-0.014015666,-0.010888211,-1.3778745e-33,0.10022331,-0.110150054,-0.014794386,-0.07657676,-0.09608291,0.065596566,-0.0218266,-0.039884776,0.002950128,-0.02063408,0.10806968,-0.039237835,0.027252194,0.00029541404,0.009343069,0.028110368,0.050580747,0.03079342,0.051532686,0.05447225,-0.058435556,0.042473488,0.061233476,0.031789426,-0.017261866,0.037536155,0.03741176,0.05547184,0.004616454,0.020106439,-0.035137434,-0.020805664,-0.055243768,-0.10680097,-0.03843385,0.013460328,-0.009283064,-0.043210573,0.009771394,-0.033420086,0.07514419,0.031226734,0.013325877,0.07966644,-0.048483353,0.027613342,-0.07849623,0.04358151,-0.016587824,-0.0018532345,-0.021367492,-0.03829594,-0.06859948,-0.005102012,-0.046462283,0.037309125,0.019672953,0.018281268,-0.055488117,0.029637732,-0.05838483,-0.0689573,-0.03379763,0.0005232655,0.055022202,0.06862418,0.083207995,0.061494064,-0.040670536,0.027354574,0.09772305,0.0047938363,0.025918124,0.039858904,-0.05994134,-0.024778755,-0.047140762,0.025109276,-0.0019658003,0.013361401,0.045975838,-0.0044090534,0.0058122566,-0.058255803,0.033908337,-0.05501055,0.0040203696,0.120208405,0.0073124403,0.005215468,0.057005033,0.0059467764,-0.047959313,-0.0155666405,0.051410377,-2.469497e-08,-0.0028842157,-0.12696819,0.058135077,-0.065610036,0.024388747,0.033271372,0.020209704,-0.013747565,-0.06753798,0.060607273,0.01601748,0.039178345,-0.057573427,-0.052791536,0.027323328,-0.016897658,-0.025734143,0.06844999,-0.008936874,0.009134944,-0.07680284,0.0011928122,-0.08691467,-0.006257917,-0.02576391,-0.021422181,0.0728841,0.009573859,0.024892885,-0.036953386,0.011884742,0.009348472,0.026279189,0.030074583,-0.13460958,-0.04916731,-0.0021533277,-0.007130045,-0.14373921,0.031841062,0.0058158124,0.07239174,-0.03334521,-0.019191314,0.0064864894,0.00565776,-0.003302175,-0.009132753,0.001509846,-0.011734371,-0.025557477,-0.029447107,-0.010978073,-0.022771081,-0.12086499,-0.0037403489,0.024838151,-0.029599259,-0.027796341,0.011031059,0.037886187,0.0747714,0.17025603,0.05098075 +1.8.3.7,"Requires a copper cofactor and Ca2+. The enzyme, which is found in both prokaryotes and eukaryotes, catalyses a modification of a conserved L-cysteine residue in the active site of sulfatases, generating a unique 3-oxo-L-alanine residue that is essential for sulfatase activity. The exact nature of the thiol involved is still not clear - dithiothreitol and cysteamine are the most efficiently used thiols in vitro. Glutathione alo acts in vitro, but it is not known whether it is used in vivo. ",384,1.0,-0.050080273,-0.044329517,-0.098613665,-0.0387946,0.016017305,0.015838727,-0.052382,0.08585175,0.0083020255,-0.009189936,0.06106268,0.002258556,-0.03755727,0.042825162,-0.079756655,0.03477374,0.006073263,0.016581371,-0.04546361,-0.07672702,0.056482706,0.028018529,-0.07196847,-0.013197834,-0.0018523275,0.04194459,-0.020858336,-0.00408961,-0.010405679,0.0012206488,-0.08100057,-0.053869642,0.02803705,-0.03214946,-0.041427374,0.052511856,-0.100066885,-0.004739816,-0.026383186,-0.059576586,0.08696038,-0.0040983907,-0.0015404272,-0.016418481,0.0064626914,-0.077874504,0.02582517,0.07510237,0.015485832,0.0086007435,-0.0020960006,-0.04568802,0.013186538,0.11441941,-0.0124996025,-0.03780926,-0.034868535,-0.02742346,-0.023143588,-0.034570172,-0.026659686,0.026932081,-0.0012434326,-0.052191306,0.038797095,-0.058726836,-0.01983672,-0.05018331,-0.02427993,0.013809477,-0.042210154,-0.002549619,-0.011682496,0.06318284,-0.038641565,0.076863125,-0.0058817985,-0.073768966,0.018318921,-0.009085837,0.092942916,0.034851924,0.024295188,0.09682831,0.0812575,0.027664032,0.0062909024,0.03740815,-0.02972791,-0.07009159,0.0789467,0.03311966,-0.08172868,-0.07998079,-0.07034065,0.028455054,-0.007990326,0.08979993,-0.019571295,-0.060372043,0.058005456,0.015979758,-0.043898426,-0.07829999,-0.044616617,0.013239632,-0.008293927,0.07104575,-0.024919564,-0.0012301543,0.016918745,-0.004975813,-0.026641194,0.0038928536,0.004557695,0.10642764,0.063174784,-0.055987105,-0.14472665,-0.010723783,-0.023046417,0.0023620245,0.038931705,0.011995846,-0.00036162065,-0.022829877,-0.063990675,3.568362e-33,0.058469187,0.0787074,0.01856687,-0.021383964,0.055588838,0.0008133601,-0.059727762,0.04829742,0.04876797,-0.02582861,-0.040053148,-0.010492913,0.011936827,-0.033619974,-0.011332096,0.00166705,-0.02206956,0.024487708,0.08898204,-0.02608537,0.026059575,-0.026196819,-0.03335861,-0.0110722175,-0.026790297,0.08320953,0.04389174,-0.009287642,0.012738047,-0.015685048,0.0093501,-0.04531466,-0.036878757,-0.001171054,0.06357687,-0.025309457,-0.029401658,-0.018610941,0.014304526,0.02478654,0.038798634,0.04661024,0.023232726,-0.024567831,0.013830227,-0.09061065,-0.11163277,0.07148897,-0.006271977,0.052642886,0.08202222,-0.054358065,0.08129864,-0.03130667,-0.056717347,0.026151508,-0.06298987,-0.07221281,0.04396339,0.043705363,0.0054109273,0.053321633,-0.085446686,0.038397882,-0.11142925,0.031027075,-0.079336114,-0.016033119,-0.039426237,0.12461428,-0.046704367,-0.07916843,-0.029825358,0.036811627,-0.00713621,-0.02009822,0.024433102,0.030850228,-0.008266537,0.028905686,0.0076726754,-0.018994551,-0.06419034,0.07678162,-0.0780664,-0.02168167,0.0028183232,0.014414289,-0.013199016,-0.009631057,0.024429347,0.037327036,-0.036196835,0.0061626025,-0.011607235,-5.320655e-33,0.10597449,-0.09522926,0.07278502,-0.07902377,0.02307797,0.025207492,-0.008562239,-0.053319983,0.13297862,-0.027275823,0.03591256,0.0534795,0.029607376,-0.028675526,0.03870913,0.016563514,-0.04664983,0.038067855,-0.026628824,-0.023184063,-0.01896714,0.06039678,0.03614365,-0.010424095,0.042859957,-0.050443113,-0.042234883,-0.002204767,0.06623438,0.108579636,-0.03422198,-0.0019101901,-0.0681051,-0.08633252,-0.043467756,0.052619714,0.039446793,0.021037236,0.068706766,0.053869043,0.04878348,0.005988989,0.059225366,0.13414769,0.027146874,0.06656516,-0.08961318,0.009270755,-0.05080024,-0.042615734,0.08690779,-0.038204484,-0.034811754,0.00831003,0.06273986,0.0885081,0.002705083,-0.061836682,-0.067850016,-0.021286603,-0.064817674,-0.060855243,-0.09669115,-0.056491766,-0.04259319,0.05406088,0.018316051,0.034703825,-0.032000322,0.009939558,0.076583855,0.03840603,-0.004542691,0.0071154884,-0.05901569,-0.011075596,-0.03568473,0.03698101,-0.0013169121,0.015569389,-0.009881832,0.051637772,0.028145995,-0.111387834,-0.00396502,-0.061724786,-0.036275815,0.16355918,-0.03290048,0.007385564,-0.09988512,-0.04238923,-0.015065346,0.064691976,-0.024284642,-4.5713378e-08,-0.06563822,0.00020485664,0.052205365,-0.044806026,-0.06895028,0.06858398,0.03958923,0.061903782,0.07362871,0.0147457,-0.004880243,0.115737535,-0.0028797654,0.026853897,0.0060633887,0.07991149,0.009170047,0.004953005,0.0031151834,-0.034076814,-0.031015571,-0.007532864,-0.06169489,0.019456774,0.00059665856,-0.018477015,0.06687836,-0.053790018,-0.12676512,0.017005593,0.05273725,0.01589586,0.010788091,-0.016912283,-0.007497654,0.024783866,-0.034826614,-0.00889446,-0.0065034623,-0.033487476,-0.0034710402,0.06321102,-0.09875234,0.015258436,0.022394659,-0.03126065,0.023924699,0.03172877,-0.027499404,0.026709242,0.003603219,-0.020270035,0.015575836,-0.077676125,-0.042690814,0.018320777,0.06799258,-0.11192922,-0.017515413,-0.04828828,0.0998233,-0.008841579,0.19885719,0.026645847 +1.13.11.83,"Requires non-heme-iron(II). Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.12.23, 4-hydroxy-3-prenylbenzoate synthase.",384,1.0,-0.05019129,-0.039176453,-0.15960367,0.0015970592,0.053193916,0.042271283,-0.07108397,0.016971167,0.064277604,-0.06612941,-0.0055933786,-0.08122976,-0.0025442163,0.016956318,-0.051961645,-0.031643257,-0.054592747,0.039576717,0.032139774,-3.872855e-05,0.036051203,0.06795634,0.028228492,0.018048258,0.013086146,0.01888293,0.097764164,0.025544314,-0.028745316,-0.04615436,0.025260286,-0.018327942,0.12099678,-0.08448705,0.11989885,0.050436813,0.016434157,-0.08180102,0.08639137,0.03936976,-0.01858989,-0.03870504,0.009542764,-0.013497184,-0.021175215,-0.056184907,0.078359164,0.0308271,-0.001977185,-0.025601828,-0.033489686,-0.039441105,-0.059199955,0.021802427,0.056365054,-0.0009900822,-0.034948453,-0.030011522,-0.005286201,-0.008841481,0.08866997,-0.055045858,0.0055030948,-0.02267468,-0.10133877,-0.019978264,0.051404003,-0.043622825,0.024861155,-0.047934175,-0.06321695,-0.0049111405,-0.02200732,0.035051998,-0.01562557,0.08890286,0.06303224,-0.041713964,-0.0036053017,-0.022817764,-0.010738359,-0.021871157,-0.0025796054,0.115130514,0.06431411,-0.0012222094,0.024026291,0.031616885,0.025903607,0.05754336,0.016953347,0.036743253,0.018158766,-0.04674558,-0.057092246,0.06434772,-0.05541353,0.0873394,0.07078166,-0.0005694474,-0.01794731,0.047433265,0.024368798,-0.011049411,0.009862158,-0.0017960453,0.009754426,0.16447091,-0.005702989,-0.016442357,0.051435526,-0.030950349,0.024320856,-0.026742816,-0.014314122,0.035275415,0.1134386,-0.05520268,-0.055654943,0.04215391,0.039345715,0.00916591,0.020469256,2.052972e-05,-0.042508464,0.009346448,-0.10074516,2.1443234e-33,0.053178247,0.08463865,0.042106096,-0.035406087,-0.028560588,0.004297103,-0.12737718,-0.023451043,-0.06338768,-0.032014567,-0.025745487,-0.022896262,0.025063643,-0.0089768255,-0.014755138,-0.07457758,0.033487912,-0.021893026,0.07541052,-0.03321079,0.022524534,0.046324104,-0.017958865,-0.049380686,0.02519731,0.052662127,0.013241591,-0.008966682,0.09743394,-0.0007138706,-0.025946967,-0.06321388,-0.045939784,-0.05616845,0.06361346,-0.0657799,-0.0595562,-0.026401134,0.027780429,0.046560407,0.04164444,0.030590272,0.0033874407,-0.047421955,0.10194697,-0.079078205,-0.06390801,0.10901552,0.042072535,0.070965834,-0.040992193,-0.019875549,0.09302888,-0.015801404,-0.07695515,-0.009005619,-0.011351084,0.028685907,0.07435729,0.063787594,0.00012154963,0.097889215,-0.027976878,0.033599924,0.058034573,-0.041270953,-0.022875188,-0.017863411,-0.03106975,0.026313508,-0.023321945,-0.018839682,0.025065834,-0.023446992,0.07340265,-0.06415325,-0.11929455,0.00485439,0.10881339,-0.0052380767,0.0042556603,0.006275909,-0.02245142,-0.036412105,-0.0890871,0.07430194,-0.107302435,0.041277997,0.006694165,0.050037988,0.015425223,-0.08548613,-0.074022576,0.0042674877,-0.004948975,-2.3086733e-33,0.086264186,-0.02808722,0.03534913,-0.087768845,-0.08903252,0.070334695,-0.04158719,-0.040569216,-0.03280668,-0.004561538,0.104261644,-0.041894775,-0.022181882,-0.11736283,-0.0161234,-0.013248904,0.0039433814,0.028951019,-0.028195655,0.0066170665,0.03430947,0.052744128,-0.0010858303,0.043897603,0.0118946945,0.026988693,0.03393375,0.04443385,0.046196174,0.12228782,-0.02982702,-0.035951786,-0.048908655,-0.09075598,-0.07779964,-0.008524274,-0.008961202,0.06368362,0.052633323,-0.047739718,0.015338427,-0.009401181,0.011268924,0.056597844,0.033756327,0.076802924,-0.06589955,0.042022876,0.024590267,-0.009918723,-0.06427547,0.007634178,-0.04822872,-0.03315246,0.00710014,-0.05757174,-0.0066216397,0.008258848,0.0072748805,-0.05718108,-0.04815172,-0.048756506,0.045128375,-0.021322638,0.10367075,0.060936093,-0.08203558,0.10336811,0.06820003,-0.030790474,-0.0060153324,0.004485653,-0.0018972396,-0.056308795,0.0030790535,0.0077315513,-0.040239036,-0.040814944,0.031616915,0.04568804,0.028657181,-0.054766953,-0.01739932,-0.01832396,-0.049861666,-0.0678629,0.062070668,-0.02242179,-0.02928131,0.027507514,-0.03540007,0.01129878,0.009952149,0.047488254,-0.018494291,-3.478084e-08,0.0016817992,-0.062499706,0.05071981,-0.029005345,0.011060699,0.0015690199,-0.038697764,-0.019395385,0.078597814,0.025394559,-0.037219815,0.021582637,0.103186116,-0.025083398,-0.022003023,0.053750277,-0.018834807,-0.005464258,0.014136227,-0.03497695,-0.020470338,0.019170856,-0.056918696,0.06839924,0.049168814,-0.09384978,-0.01704654,-0.010719719,0.035586122,0.018736752,-0.0024777185,0.006112211,-0.017895792,0.033978526,-0.027345462,-0.074188374,-0.060484286,-0.047454394,-0.049170807,-0.019826248,0.05501443,-0.0031847828,-0.107394636,0.023492873,-0.034712013,0.024993537,-0.00036713705,0.06112507,-0.061570324,-0.06431343,0.08682683,0.021397687,0.03191417,-0.002814318,-0.104281574,0.082298145,0.0683799,-0.0798025,-0.027685398,-0.00082422636,0.0012461672,-0.06228702,0.14763309,-0.022413697 +1.13.12.23,"Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.11.83, 4-hydroxy-3-prenylphenylpyruvate oxygenase.",384,0.99999994,-0.09224662,-0.02786103,-0.12961826,-0.046684675,0.031023892,0.055837184,-0.08500472,0.04671068,0.086948805,-0.06561162,0.024678769,-0.06583061,0.004485414,0.024041334,-0.030749546,0.019404113,-0.08607998,0.022294225,0.04444752,-0.04271672,0.07112747,0.06646886,0.035898548,0.003830356,0.052710894,0.034023475,0.05106229,0.016427055,-0.011083639,-0.028286882,0.045091,-0.020923434,0.12722121,-0.09825391,0.15776086,0.076536834,0.018548638,-0.09085223,0.09118036,0.06316003,-0.0021051397,0.008518829,-0.009540967,0.050913174,-0.029207507,-0.056911662,0.04473369,0.05870066,0.008307197,-0.043356232,-0.02422724,-0.046739046,-0.08331857,0.028379751,0.08648798,0.015707847,-0.057428896,-0.032408502,0.004836787,-0.011022301,0.09996833,-0.044477455,0.060295254,-0.0072562397,-0.10987531,-0.043813813,0.05358627,-0.058733296,0.046078533,-0.068592265,-0.08007612,-0.015561943,0.018973745,0.034151193,-0.031600624,0.03638798,0.02689891,-0.045502216,-0.0011942358,-0.023686837,0.031314496,-0.03485723,-0.030655991,0.096540734,0.07065427,-0.06760304,0.032535553,-0.003215695,0.027510043,0.04877284,0.018314946,-0.01493067,-0.021642353,-0.06635028,-0.06322941,0.033648856,-0.05961117,0.045951955,0.06680429,0.012561895,0.005617643,0.05612732,0.041663762,-0.033960737,-0.014982076,0.013481442,0.0037318934,0.12580904,-0.0010945328,-0.020407751,0.03176666,-0.042043902,-5.5925113e-05,-0.02629833,-0.049575467,0.06113254,0.060727548,-0.06483543,-0.06493849,0.026536653,0.013968886,-0.038698923,0.047868777,-0.0012531739,-0.032189343,0.019606626,-0.090943545,3.1954796e-33,0.061004963,0.027333606,0.01851299,-0.049627643,-0.0069544725,-0.028321685,-0.07918752,0.014938394,-0.08100515,-0.021673935,-0.028119264,-0.022654371,0.02877604,0.0064214584,-0.012543413,-0.051326588,0.03340525,0.0069371955,0.05093343,-0.05317834,0.03204842,0.01830159,-0.014531273,-0.036757033,0.051585525,0.03533541,-0.039350316,0.013215571,0.15294,0.0038762013,0.00037756359,-0.08709702,-0.039599285,-0.04040107,0.02051653,-0.03502998,-0.081211165,-0.06303813,0.053703297,0.028332712,-0.011285711,0.016035529,0.0074626715,-0.059958253,0.07016372,-0.038403396,-0.046638902,0.09161757,0.062233455,0.079606704,-0.042065006,-0.067013495,0.08611895,-0.010645405,-0.07400882,0.014517647,-0.0045649353,0.029711995,0.05303091,0.044159606,-0.008633682,0.088626556,-0.028707996,-0.0055573727,0.06061701,-0.02684244,-0.02354425,-0.02734233,-0.041999996,0.048669953,-0.039399702,-0.006515019,-0.01935119,-0.055768415,0.06622803,-0.030984942,-0.07970078,0.041448895,0.056779608,-0.009155051,0.025051547,0.0052651535,0.0067509054,-0.04704737,-0.08353518,0.08994857,-0.09468528,0.036287718,0.020378884,0.08897963,0.012565857,-0.07658635,-0.03908589,0.018482706,-0.0051465733,-3.1601928e-33,0.08868009,-0.05268819,0.03610933,-0.13914484,-0.070048966,0.10756145,-0.054539036,0.019406702,-0.051063776,-0.018752774,0.047636617,-0.009597807,-0.003890338,-0.09792465,0.009504154,-0.032810755,0.020612769,0.073234305,-0.043419544,0.057957623,0.05487008,0.052574404,-0.0057672556,0.045843046,0.008211188,0.03038284,0.04895403,0.023464736,0.060122643,0.06582235,-0.040607095,-0.032811966,-0.06702397,-0.02787343,-0.052089233,0.0018739724,-0.02948208,0.04516113,0.04570997,-0.013278331,0.02695567,0.028380793,-0.0063920957,0.051965386,0.0464726,0.05512433,-0.05339746,0.034393556,-0.0010309393,-0.038702995,-0.06853473,0.01617927,-0.039448828,-0.02990553,-0.0044545527,0.0043440033,-0.014451304,-0.020525841,0.02427163,-0.09919032,-0.052615445,-0.070397876,0.005758304,0.010390687,0.0858127,0.06523189,-0.06366369,0.061310716,0.06061959,-0.04278329,-0.0017938626,0.025707096,-0.07557207,-0.04108816,0.007196483,0.022022696,-0.06690851,-0.08077871,0.04373132,0.05518314,0.030645724,-0.037251517,-0.000551795,-0.054937318,-0.06544256,-0.060595054,0.05497028,0.024500938,0.03170551,0.03493707,-0.02586436,0.020697538,-0.025115993,0.06407552,0.016475542,-3.456168e-08,-0.002160959,-0.03327897,0.09303565,0.027507223,0.019325178,-0.023987157,-0.0005861447,0.017936397,0.047499917,0.00933937,-0.014946172,0.01694851,0.089694306,-0.08662004,-0.012589405,0.037782054,-0.05101711,-0.019696208,0.022599671,-0.00055285037,0.014577266,-0.0002134555,-0.0080326935,0.1068734,0.035671536,-0.07617389,-0.00037293858,0.019912476,-0.01576221,0.005924743,0.015370665,0.0021867582,-0.043606527,0.029989753,-0.033242926,-0.07892722,-0.05111776,-0.045749716,-0.040587943,0.0020767949,0.048635922,-0.033471256,-0.09456487,0.028896984,-0.04740477,0.056510683,0.021976283,0.013579564,-0.05099289,-0.04746751,0.07496177,-0.010607021,-0.027040105,0.007406179,-0.11046966,0.034147255,0.039193194,-0.074721724,-0.077119716,-0.005012203,-0.012763878,-0.023803374,0.19211328,-0.0144301 +1.14.13.237,"The enzyme is a member of the flavin-dependent monooxygenase (FMO) family (cf. EC 1.14.13.8). The plant Arabidopsis thaliana contains five isoforms. GS-OX1 through GS-OX4 are able to catalyse the S-oxygenation independent of chain length, while GS-OX5 is specific for 8-(methylsulfanyl)octyl glucosinolate.",384,0.99999994,-0.07766143,-0.03922668,-0.08051745,0.057558443,0.09805268,0.013768321,-0.09918546,0.027453532,0.030323282,-0.044290327,0.08633502,0.006160328,-0.08310868,-0.025641218,-0.01890814,0.032154717,-0.06602693,0.031784296,-0.08374671,-0.06984426,0.08390245,0.031009598,-0.005634437,-0.015697716,0.016720679,-0.05809824,-0.050190438,-0.0074930373,-0.0071125138,-0.06854646,-0.0117769055,0.021454666,0.104819536,0.017367987,-0.035735033,0.061469845,0.059940446,-0.10515825,0.049734708,0.0013393721,-0.00615291,-0.0019865069,0.015922753,-0.060325027,-0.07179197,-0.031355307,0.0037023711,0.0013584767,0.0017220445,0.010203413,-0.018145999,-0.078567475,-0.11331117,0.026867643,0.008088648,-0.01960758,-0.022459937,-0.048422314,-0.035059527,0.042533126,-0.017126692,0.00048226534,-0.014279645,0.05461196,0.019726895,-0.017777393,0.03283321,-0.047063872,-0.004252525,-0.05695131,0.00016123273,-0.06255413,-0.025794752,0.0046408097,-0.076371,0.11842842,-0.008569932,0.028778218,0.06178712,-0.0045713885,0.060783267,0.032234404,0.037412647,0.09034597,-0.011096074,-0.044304237,-0.08331002,0.04956708,0.016921865,0.07154152,0.02844176,0.031607747,0.0023237967,-0.04221304,-0.009292653,0.07873796,0.052467603,-0.0014800219,-0.05622894,-0.016795846,0.01669197,0.03428189,0.0033447011,0.008336593,0.0055588367,-0.008611866,-0.037054114,0.02407632,0.023037534,-0.06825642,0.0013136241,0.007102569,0.021437205,-0.031234277,-0.05134688,-0.004157299,-0.028390087,-0.018664699,-0.059163917,0.043292742,-0.03104188,0.0012956838,-0.02096327,0.009042625,-0.009119725,-0.04923682,-0.13115336,1.9081106e-33,0.044882458,0.06059747,0.014270675,-0.037207723,-0.010438363,-0.07456588,-0.0038233425,0.035414934,-0.07361489,0.068911925,-0.14729308,0.011060462,0.00413548,-0.038227968,0.0026138122,-0.018953266,-0.045875743,-0.009018128,0.031723462,-0.0006101692,0.0066137463,-0.0028214166,-0.02007712,-0.028782113,0.010669731,0.088476986,-0.012581971,-0.06949416,-0.038362607,0.011691817,-0.016198134,-0.07277623,-0.06183963,0.012604903,0.0261076,-0.040147264,-0.053569775,-0.04508683,-0.060644865,0.05369081,-0.023580093,0.054012906,-0.045687456,-0.01695653,0.06465851,0.008790946,-0.08600742,0.0729424,0.100038484,0.16467743,0.0320308,0.01701596,0.04553199,-0.011937148,-0.016071303,0.03106909,-0.002308288,0.033026677,0.0032347867,0.048679966,-0.015380815,0.050508432,-0.03747375,0.027331153,0.01597018,0.08816898,-0.08700361,-0.11358347,0.027964175,0.11518554,0.042145092,-0.019830141,0.039271574,0.047014892,0.03369129,-0.020517854,0.0076048137,0.0013067118,0.001033417,0.028133107,0.015858706,0.014993305,-0.0027401312,-0.022623004,-0.090372145,-0.03451701,0.003914431,0.0077717854,-0.031988364,0.043599863,0.07639267,-0.04682138,-0.0017673678,-0.046290394,0.05190858,-2.1591969e-33,0.05095619,-0.048741713,0.005567081,-0.1362,-0.023974232,0.09168106,-0.022437476,-0.030120905,0.00617429,0.08827839,0.022800833,0.03903664,0.011884808,-0.06204923,0.027158888,-0.010760136,-0.0180451,0.017339062,0.013501104,0.05166073,-0.0088631045,0.074807264,0.021777777,0.05912219,0.084965825,-0.005118045,-0.00031343487,0.09389208,0.03844039,0.018257525,-0.0027109815,0.031340178,-0.0064415135,-0.0123991845,0.026034482,0.004898734,-0.053427994,0.08724562,0.015193555,0.02685817,-0.004546257,0.062213182,0.086784594,0.10453897,0.015925754,0.0631254,-0.10418684,-0.009427419,0.019515255,-0.05825794,-0.046908803,0.031028109,-0.10970021,0.031512167,0.052919928,0.01406003,-0.0032663965,-0.005193595,-0.07880218,-0.06026035,-0.011369807,-0.091019854,0.016074969,-0.0061922423,0.044304024,0.07224601,0.06900983,-0.02343081,-0.023124842,0.0472079,0.0740532,-0.027468376,0.049295083,-0.012390278,0.0014327865,-0.0016467717,-0.054068826,0.001603613,-0.07171353,-0.014284652,0.035412375,0.05268709,-0.022899857,-0.033112217,-0.009226259,-0.08478649,0.02051201,0.17236143,0.08925957,0.033579934,0.016989056,0.02091742,-0.04464078,-0.024516333,0.046798684,-3.842131e-08,-0.03482627,-0.0790005,0.06887996,-0.02319357,0.0007292065,0.099098206,0.0067641027,0.01871385,0.051593605,0.00065034797,0.028015364,0.07736375,0.010909001,-0.02249862,0.04199006,-0.07250538,-0.034941703,0.08359463,-0.004777003,0.065327965,-0.051240373,0.016231136,-0.06292498,-0.014174075,-0.0032833344,-0.059442066,-0.0018929639,0.016358145,0.0537782,-0.0055947346,0.038296092,0.0693327,-0.010819878,-0.038195644,-0.20158914,-0.08086786,0.054177742,0.0024862776,-0.068599105,0.022816757,-0.037168507,-0.021417234,-0.05951039,0.01291473,0.024422161,0.014856861,0.043930776,-0.020407567,0.017088553,0.057672467,-0.007446487,-0.042845633,-0.08946947,-0.03510793,-0.068988524,-0.05541275,0.019927265,-0.008127256,-0.04305218,-0.06337515,-0.027934127,0.009146755,0.18896969,-0.039039962 +1.14.13.238,"The enzyme, characterized from several bacterial species, is involved in a pathway for the degradation of methylated amines. It is composed of three subunits, one of which is a ferredoxin, and contains heme iron and an FMN cofactor.",384,1.0,0.021783693,-0.031164203,-0.1138577,0.0038236277,0.07532233,0.018935861,-0.014557266,0.00010327643,0.004275469,-0.051831983,-0.021271482,-0.0543971,-0.041304763,0.06581788,-0.05499752,0.01766225,-0.13772301,-0.037899677,-0.042453915,0.0032301154,0.026997926,0.09174691,-0.021249535,0.006729856,-0.06656334,0.038494136,0.042036522,-0.029386653,-0.016893962,-0.033612534,0.017150475,0.025075695,0.083344676,-0.010839808,0.05970143,0.099724814,0.034844607,-0.053732514,0.03303849,0.028054573,-0.009143926,0.043283254,0.0024336174,-0.107418105,-0.035441935,-0.011957997,0.04922944,-0.058725614,0.02708647,0.029283347,-0.03469753,-0.054038666,-0.0073841116,0.09810238,0.061201084,-0.023541914,0.025018932,-0.06956394,-0.098896906,0.03676874,0.016935121,0.022917591,-0.05825227,-0.014298041,0.07861561,-0.01850564,0.014777586,-0.12765355,-0.042401254,-0.04031599,-0.03525941,-0.10376635,-0.06604931,-0.01435121,-0.026572626,0.0067832614,0.07023506,-0.06532376,0.049704373,-0.029868975,0.00090051506,0.0295673,0.055964388,0.07206574,0.042212307,0.0004307916,-0.019108886,-0.031168852,0.031998478,0.06517318,-0.0064044516,0.04971936,0.01646801,-0.113724545,0.015677039,0.026858563,0.02670953,0.013627964,0.093524545,0.0302582,-0.032067645,0.027416222,-0.07480671,-0.08583384,-0.07716113,-0.0042250575,0.04691331,0.15499423,0.044646442,0.015014656,-0.00618524,0.031686187,0.07291692,-0.0002120891,0.004068655,0.034445122,0.072368346,-0.004775609,-0.032435413,0.060771715,0.00820128,-0.0026086827,0.10741068,0.08280321,-0.008164343,-0.013043618,-0.12732428,-2.4388413e-33,0.06823969,0.012606779,-0.028185232,-0.03576112,-0.010445747,0.021168686,-0.033173803,0.035234682,0.034397785,-0.06518635,-0.08027499,-0.07535128,0.028771436,-0.018502248,-0.0086270515,-0.06680251,-0.04016565,-0.0051193335,0.037041236,-0.028217526,0.048346024,0.079445295,0.0077003506,-0.017686332,0.008929054,0.044590555,0.006246091,0.044471957,-0.040850174,-0.021864854,0.017469918,-0.082415245,-0.15069532,-0.004011432,0.08450095,0.01127486,-0.04024385,0.04745829,-0.054645948,0.09406576,0.034478765,0.032839827,-0.018767636,-0.06219376,0.04727415,-0.009015755,-0.04665728,0.094622575,0.016689023,0.053230394,0.007973835,-0.022729337,0.07080377,-0.05610015,-0.10879953,0.010203156,0.020569058,-0.021691434,0.03244539,0.026929166,0.019883439,-0.0018909386,-0.03693787,0.051937208,0.059337392,-0.023476494,-0.0038244887,-0.016824836,0.0713086,0.06791643,-0.08397651,0.0072329063,0.06359498,0.0022834798,0.008112175,-0.08896173,-0.105522744,-0.014888699,0.097529,0.025836261,-0.023017641,-0.022871725,-0.007206271,-0.03430326,-0.07616271,-0.001909775,0.022358978,-0.068933405,-0.05052885,-0.0037086038,0.040509082,-0.11582706,-0.05064278,-0.029681604,0.032334317,-5.0287208e-34,0.030273171,-0.07954175,0.03694756,-0.090655215,-0.08987325,0.03806783,-0.026214845,0.018099213,-0.06167475,-0.039107915,0.08202902,-0.00030669378,0.026153255,-0.026210627,0.0020801446,0.054175574,-0.020842548,0.018144444,0.04615366,-0.003000127,-0.020434149,0.0031874664,-0.0045180153,-0.004072903,0.047859,0.014859661,-0.018967276,0.056737244,0.13949315,0.052696876,-0.043948498,0.022625575,-0.021757973,-0.07469305,-0.023837332,0.05976912,-0.029538905,0.005576782,0.03669333,-0.035842806,0.052414853,0.029064639,0.053400222,0.09790933,0.015485712,0.09424506,-0.12741245,0.014386764,-0.0043477546,-0.0048473207,-0.010198397,-0.038178254,-0.026393004,-0.0061798478,-0.0033386152,-0.017690763,0.02222658,0.027242953,-0.03965104,0.014399422,-0.025112113,-0.026744325,0.045822617,0.06903244,0.019711882,0.02369377,-0.0117607815,0.029880822,0.03418969,0.008413011,0.0590109,-0.015188403,0.09782653,0.004410104,-0.042790096,-0.07047845,-0.05016364,0.024486722,-0.0036606046,0.0048733316,0.03217989,-0.013346249,-0.03312052,-0.058329865,-0.018297926,-0.07091782,0.065696076,0.093495086,-0.007952615,-0.011588442,0.00011870908,0.0132830655,-0.033286903,0.019359041,-0.0022662948,-3.6005606e-08,-0.002318051,-0.118416734,0.010241414,-0.0671505,0.022649026,0.081488945,-0.00312955,0.01747318,0.059530154,-0.009462788,0.018338664,0.090245895,-0.07174534,-0.002025144,-0.010450592,-0.0031971955,-0.10252744,0.012544028,0.0070197927,-0.019848013,-0.09267273,-0.00017671347,-0.09245486,0.037902273,0.010738256,-0.029674368,-0.039193526,0.06041203,0.002880767,-0.019690474,-0.02074033,0.095736906,0.0216531,-0.029439218,-0.118216716,0.0022473636,-0.013783087,-0.059736997,-0.048995733,0.014596253,0.025642645,0.025759203,-0.102687225,-0.05348135,0.05841425,0.010996564,-0.0020883405,0.075805195,-0.003011908,-0.028116459,0.033638276,-0.009431238,-0.00431901,0.019720875,-0.089103326,-0.005271144,0.01564496,-0.082628205,0.03245774,0.000806062,0.015024502,0.020919716,0.16712305,-0.050587974 +1.14.14.48,"A cytochrome P450 (heme thiolate) enzyme found in plants. The enzyme acts on jasmonoyl-L-amino acid conjugates, catalysing the hydroxylation of the C-12 position of jasmonic acid. While the best studied substrate is (+)-7-epi-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-valine and jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates.",384,0.99999994,-0.09860372,0.0026141515,-0.035057202,-0.053784512,0.034530118,0.08783632,-0.06001286,0.059944816,-0.01081962,-0.0019448097,0.04451463,0.005590888,0.010162159,0.0008536114,-0.023171937,0.030754024,-0.028370552,0.043894697,-0.041810814,-0.036031887,-0.05189208,-0.01386999,-0.028603744,0.0045315516,0.07191052,-0.0505856,0.047198683,-0.029586382,-0.080702595,-0.033813328,-0.07221359,-0.014084009,0.04224637,-0.058996458,0.0004135581,0.037083063,-0.097710595,-0.10071325,0.07142003,-0.03518783,-0.0005555689,0.016644247,-0.06592592,-0.03712816,0.013873749,-0.046311557,0.0073798457,-0.0023767354,0.03341602,-0.040922433,-0.057666928,-0.041122757,-0.031245029,-0.010014815,-0.06638573,-0.014920668,-0.04368842,0.01665624,-0.027972782,0.058611326,0.0114961155,0.0408576,-0.0112906145,-0.032710694,-0.011791559,-0.08173297,-0.039192554,0.011283123,0.054596357,-0.07723172,-0.020951979,-0.08331104,-0.00797079,-0.042434175,-0.09537082,-0.006152724,-0.018290717,0.032831427,0.05293192,-0.02832841,0.016367223,-0.027507376,-0.040354583,0.06989934,0.06843645,-0.008279035,-0.058777593,0.057418417,-0.0029887708,0.06380951,0.06488604,0.05171933,-0.069069535,-0.023257429,-0.09276752,0.027071053,0.035403647,0.029129596,-0.009619481,0.010689819,0.056911226,0.08235596,0.0072926483,-0.096124806,-0.0669012,0.0068692416,-0.040748592,0.021300955,0.054020666,-0.090658866,-0.028194688,-0.08318834,-0.043944497,-0.032255247,0.006693755,0.11414355,0.063666046,-0.035277095,-0.02822986,-0.056951527,-0.031144513,-0.01915302,0.08891897,0.0068030674,-0.024106894,0.040657427,-0.055662893,4.4590762e-33,0.09991132,-0.0009584119,0.0003227793,0.04208031,0.0025485505,-0.0035444207,-0.10677287,0.116106614,-0.06373802,-0.05609125,-0.085708596,-0.057177495,0.01319357,-0.0729607,-0.03295876,0.0027509297,-0.03463557,-0.048958883,0.04304897,0.01246675,-0.010350102,-0.027378296,-0.022356989,0.0017440034,-0.019871496,0.06808503,-0.017131891,-0.0009002579,-0.015444848,0.037511982,-0.0037299723,-0.08075431,-0.0672922,-0.0017798792,0.047704555,0.026574956,-0.014898341,0.015417229,-0.048372585,0.010731909,-0.021499332,0.011438997,0.035599,-0.059712548,0.04753313,0.014733165,-0.08031422,0.021859117,0.027391668,0.06062664,0.03323674,-0.034516666,0.12749743,-0.00078426086,-0.001894294,0.08083627,0.044182397,0.06216458,-0.0041083777,0.09837842,0.08496539,0.06376624,-0.025737628,0.080518045,0.046979945,0.06010849,-0.06494325,-0.02694292,0.0083786575,0.12892377,-0.049711544,-0.027860709,0.06827107,0.015796341,0.06088173,-0.051627733,-0.04367193,0.0642377,0.016545767,0.0248523,0.069091596,-0.021826092,0.029269712,-4.108053e-05,0.035166964,0.034463715,0.032152705,0.0049325335,0.016760131,0.0793562,0.068859525,-0.06075526,0.04934324,0.031143125,0.0036551547,-4.8713188e-33,0.07725894,-0.05147613,-0.024628194,-0.049645912,-0.06039686,0.041768022,-0.0057414128,-0.06411003,-0.040087044,0.020461837,0.08918204,0.0115882,0.011417235,0.032562137,0.004608153,-0.012672414,0.014712107,0.0675654,-0.052258197,0.007591153,-0.04445591,-0.0021909701,0.034356754,0.02041908,0.0020441038,0.0055848965,0.03945421,0.04269819,0.06345804,0.08329726,-0.02699772,-2.1820164e-05,-0.045878105,-0.07094271,-0.019750917,0.044175774,-0.0057034944,0.0052903024,0.04362231,0.0698869,-0.035836454,0.036384817,0.003600259,-0.0076677366,-0.014172566,0.039243955,-0.08962171,-0.0033282535,-0.05123034,-0.02299437,0.0859984,0.0067747408,-0.023360915,0.042961095,-0.02617925,0.063617095,-0.036821205,0.07945021,-0.03690223,-0.016353205,-0.047600996,-0.068849035,-0.018288055,-0.01552878,0.0030465021,0.07036389,0.002368142,0.1182367,0.008386698,-0.028996196,0.03241663,0.0031312215,0.05777734,0.105548315,-0.044459306,-0.022901589,0.04137958,-0.009678448,0.026679635,-0.006504343,0.039783917,-0.006951251,-0.052293986,-0.05728964,-0.03268136,-0.1228297,-0.042239685,0.10515125,0.08829671,0.0015279535,-0.0052439533,0.057704538,-0.069219805,0.035254423,0.06308817,-4.6319645e-08,-0.034635574,-0.11754076,0.0150611745,0.0052286303,0.02115167,0.024632443,-0.011647715,-0.053286217,0.045638077,-0.024594601,0.0026561427,0.12725879,-0.056782108,0.011339425,-0.07472631,0.00095648196,-0.005836976,0.0586539,0.0010466885,0.10182478,-0.058268324,0.04425735,-0.08319054,-0.031793077,0.061538752,-0.13147376,-0.055460103,0.013120361,0.06505798,-0.004762767,0.002661699,0.02558051,0.018706692,-0.055043384,-0.086791,-0.0054882923,-0.017743528,-0.06525766,-0.068106405,0.0063500567,-0.0017936394,-0.0719586,-0.10235472,-0.0053324425,-0.018847706,-0.021107273,0.041877754,0.027484147,-0.048475225,0.040965836,0.0017331844,0.018413858,0.0965928,-0.08935924,-0.06257382,-0.00091500947,0.096139744,-0.08479851,-0.033445712,-0.05784992,-0.0030574487,0.017788418,0.1970745,-0.013112311 +1.14.14.49,"A cytochrome P450 (heme thiolate) enzyme found in plants. The enzyme acts on jasmonoyl-L-amino acid conjugates that have been hydroxylated at the C-12 position of jasmonic acid by EC 1.14.14.48, jasmonoyl-L-amino acid 12-hydroxylase, further oxidizing that position to a carboxylate via an aldehyde intermediate. While the best studied substrate is (+)-7-epi-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates.",384,1.0,-0.07344298,-0.025178252,-0.009179562,-0.040999237,0.061676048,0.08446855,-0.060632084,0.021305708,-0.0019407053,0.006767318,0.046565697,0.026136355,0.008627297,0.019203404,-0.024893377,0.053773403,-0.03650506,0.014998663,-0.016186774,-0.016916621,-0.04047006,-0.017753033,-0.03501886,0.012384249,0.088894956,-0.06860495,0.04395356,-0.03390996,-0.09064073,-0.021006724,-0.07731782,-0.029780978,0.04812317,-0.039550066,0.0036640265,0.01867892,-0.09665266,-0.10275031,0.06309106,-0.03806486,-0.02211142,0.006222063,-0.049688186,-0.045995433,-0.021471402,-0.045198664,0.01959332,-0.02511659,0.018996004,-0.032383803,-0.048328348,-0.017175911,-0.014533136,-0.01786129,-0.053338304,-0.012430087,-0.04562749,0.021864828,-0.038787153,0.062061485,-0.002487112,0.029614648,-0.012782973,-0.04486508,-0.029139483,-0.06094511,-0.043917507,0.0070668585,0.071906604,-0.08100861,-0.03129124,-0.09941198,-0.0044216043,-0.044800483,-0.0830498,-0.0298605,-0.018075308,0.040148035,0.06276687,-0.029383242,0.024216047,-0.028361235,-0.031294245,0.06632969,0.056526124,-0.011900781,-0.06467054,0.06650375,-0.0052273064,0.035482936,0.06459141,0.032084785,-0.06458157,-0.002154925,-0.055387426,0.010703389,0.044660714,0.0314976,-0.024239881,0.00202951,0.05116004,0.06523955,0.019179543,-0.0997391,-0.080524504,0.025219422,-0.02863706,0.024226665,0.0461578,-0.0815263,-0.005828301,-0.076763384,-0.018315155,-0.028356792,-0.00319768,0.09369005,0.046671312,-0.035311278,-0.03941936,-0.0383474,-0.023688385,-0.004643827,0.10611558,0.013139576,-0.020860422,0.071593806,-0.076056555,4.1838423e-33,0.10802708,-0.0069414387,-0.009847654,0.058515005,0.006043667,-0.004370932,-0.09507811,0.12117574,-0.03218143,-0.063904926,-0.08344317,-0.05428108,0.012917682,-0.07878398,-0.038402822,0.01384833,-0.079013176,-0.057239033,0.04923296,0.04689312,-0.016398275,-0.0059918365,-0.031588856,0.028473591,-0.021839958,0.06431936,-0.02873312,-0.020390831,-0.016618768,0.04113083,0.008707978,-0.085787654,-0.08454215,-0.0025059867,0.057770148,0.034487735,-0.02064312,0.0025048887,-0.061100334,0.020265272,-0.02195197,0.01824825,0.035463363,-0.083497606,0.055589847,-0.0008279735,-0.085870504,0.054484475,0.014215688,0.06450639,0.041010387,-0.028286649,0.12975626,-0.012587231,-0.013517221,0.085729994,0.043218363,0.038189493,0.020215325,0.095160596,0.06620853,0.06133174,-0.022378562,0.06522106,0.039150804,0.06829992,-0.07310037,-0.023107698,-0.012091719,0.1368853,-0.032037504,-0.051962577,0.0667645,0.029347658,0.05532936,-0.06240559,-0.0490782,0.07072119,0.020193594,0.031458955,0.07958258,-0.030420879,0.037049174,-0.02676515,0.01977083,0.016856734,0.031058127,0.0016919986,0.008370731,0.085602604,0.061411656,-0.06552123,0.041187357,0.032598373,0.00075265544,-4.567012e-33,0.10590328,-0.07749143,-0.014746049,-0.045187764,-0.049682442,0.04071221,0.012992162,-0.048400585,-0.018380214,0.0006079403,0.07288699,0.008155157,0.015115262,0.035158817,0.027174927,-0.014803912,-0.0017128399,0.07602821,-0.033097442,-0.005020535,-0.038599726,0.008236648,0.033078413,0.019376267,0.036070198,-0.003751707,0.029807864,0.05234892,0.06910666,0.061013382,-0.044514544,0.0024513917,-0.030789416,-0.07273573,-0.016275434,0.053900976,-0.04215055,0.0046866178,0.026394742,0.06737399,-0.046786513,0.0300387,0.004959326,0.019846484,-0.005800106,0.025322074,-0.12488392,-0.001765797,-0.042724606,-0.04039434,0.068323985,0.010462897,-0.029942255,0.017762221,-0.035116214,0.08414974,-0.031886637,0.09530831,-0.023709208,0.011137627,-0.04947317,-0.07221357,-0.019432703,-0.007249569,-0.0023962671,0.06034498,0.00059487985,0.113816984,0.023643427,-0.027744472,0.035811767,-0.0065803616,0.0663794,0.11667474,-0.03287788,-0.017874952,0.021922175,-0.006179258,0.016888512,-0.010344141,0.038177077,-0.017818065,-0.026412545,-0.028249148,-0.018469341,-0.11309905,-0.038533006,0.105381265,0.07297152,-0.001530981,-0.000725866,0.041057557,-0.07411729,0.034462634,0.061156772,-4.6904077e-08,-0.0385422,-0.08749759,0.02047231,-0.014568812,0.023316117,0.010924585,0.006298806,-0.024177328,0.03330419,-0.054591373,0.017006973,0.12985572,-0.058990944,0.024423193,-0.06012174,-0.013415204,-0.024241446,0.05176221,-0.020391641,0.119754635,-0.054880247,0.044165693,-0.096365646,-0.009412002,0.03268849,-0.121439606,-0.043730624,0.03841917,0.053657476,-0.0021692754,0.00021366733,0.031104561,0.015751699,-0.06555938,-0.1182523,0.0006499423,-0.016202997,-0.069941156,-0.072860174,-0.007685132,-0.00950807,-0.08429867,-0.07181258,-0.012412896,0.0017716859,-0.030490281,0.020365039,0.0241678,-0.045577187,0.043307874,0.018635303,0.014250302,0.07036108,-0.07541778,-0.059145145,-0.010019108,0.091796435,-0.074906036,-0.002217667,-0.06563292,-0.001113461,0.03867889,0.20971374,-0.01920329 +1.14.14.50,"This cytochrome P-450 (heme thiolate) enzyme acts on 16-methoxytabersonine, leading to biosynthesis of vindoline in the plant Catharanthus roseus (Madagascar periwinkle). It can also act on tabersonine, resulting in the production of small amounts of vindorosine. The products are unstable and, in the absence of EC 1.1.99.41, 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase, will convert into 3-epoxylated compounds.",384,1.0,-0.07828994,0.021446027,-0.12110333,-0.07863012,0.028292743,0.054189,-0.09877526,0.10573215,0.0017655948,-0.015309182,-0.008205577,-0.012589736,-0.007653899,-0.052041456,-0.06868676,0.05728224,-0.0765304,0.054126058,0.006618349,-0.007411084,0.019586949,0.023032628,-0.0013211822,0.015543207,0.044061296,0.028667985,0.009038289,0.052191373,-0.09435054,-0.056034822,-0.050113894,0.025466109,-0.014334201,-0.040765457,-0.01213176,0.093492456,-0.07190855,-0.013611897,0.042603545,0.06624002,0.025464343,-0.046552915,-0.085742705,0.00893575,6.685187e-05,-0.037631854,-0.006735628,0.05454505,0.05474754,-0.08380827,-0.05121708,0.013379019,-0.020271167,-0.04197186,-0.04106284,-0.07706844,0.04946846,0.046057314,-0.016536992,-0.009863268,0.028595908,-0.00028970337,-0.017391909,0.0031190515,-0.010139138,-0.043728303,-0.023215301,-0.028204292,0.01046848,-0.09261187,-0.0316686,-0.033153407,-0.0115085505,-0.020908227,-0.09816936,0.07945319,-0.026173137,0.027335502,0.036108628,0.0017729771,0.007509648,0.00704942,-0.040091857,0.07702829,0.063623466,0.08603341,-0.012763586,0.04210699,0.023443395,0.037020765,0.0024154228,0.043465678,-0.022677574,0.01670368,-0.097634524,0.054475307,0.04110181,-0.020234972,-7.262641e-05,-0.019174,0.031243984,0.046802636,-0.045615435,-0.076628014,-0.10689775,0.025437688,0.017620426,0.07567657,0.026378758,-0.045336407,-0.0153253665,-0.043992285,-0.011652645,-0.025008654,-0.030050226,0.15372425,0.030541511,-0.032897886,-0.055472214,-0.029721908,-0.036229502,-0.034311026,0.02035214,0.014467757,-0.039306354,-0.06818978,-0.002721394,3.6605702e-33,0.07560181,0.07716811,-0.043287467,0.0019794211,0.048268367,0.041134108,-0.15494193,0.019578535,-0.048026476,-0.053455774,-0.10191239,-0.088440396,0.0045442916,-0.035566933,-0.046501696,-0.014335205,-0.01862044,-0.004528648,0.026380971,-0.022864796,0.009731718,-0.01741535,-0.036488142,0.0150416205,-0.01880056,0.08393819,-0.0034618285,-0.017463736,-0.0038085198,0.010755754,0.014981853,-0.14785495,-0.023592446,-0.019991307,-0.06285398,-0.008270604,-0.092479564,-0.03975459,0.0044899215,0.095270686,-0.02856706,0.029738579,0.047711045,-0.030202229,0.049054667,-0.04253529,-0.02579914,0.14505337,-0.006492318,0.046446603,-0.011743193,0.010409098,0.13795744,0.02040193,-0.08113899,-0.021317344,0.021808028,0.001093858,0.032143652,0.049724307,0.13701838,0.06666039,0.008011633,0.0021293967,0.0010362186,0.04814787,-0.045854967,0.02233363,0.06217661,0.08145278,-0.016499752,-0.0016913948,0.004329603,-0.038950928,0.072580755,-0.029862577,-0.009804102,0.052139346,0.054334942,0.0051301504,0.0012696272,-0.0064561586,-0.019848417,-0.008264701,0.011961095,0.056021698,0.03196722,0.00024135702,-0.037671957,0.12022222,0.06698743,-0.07632285,-0.0040319143,-0.028702926,0.071090326,-2.6659407e-33,0.044545364,-0.028698353,0.019923178,-0.095224224,-0.020281656,0.052876607,-0.039533723,0.014322605,-0.040032372,-0.027199708,0.045501396,-0.034243822,0.024367396,-0.006382451,-0.031490993,-0.005560663,0.030100033,0.060183015,0.015819207,0.004427023,-0.008883886,0.018499369,-0.013906823,0.058626316,0.020711597,-0.012206318,0.008569009,-0.045652293,0.042533193,0.04266541,-0.0009438369,0.012919478,-0.085883856,0.02208063,0.00032623103,0.095266454,-0.004297557,0.060287092,0.038202133,0.061315425,0.014064098,0.01005475,-0.024786305,0.02011668,-0.0048823203,0.04011195,-0.074771255,0.025249211,-0.033593386,-0.031368066,0.078158654,0.07087924,0.016013544,0.046032377,0.029717898,0.048042513,0.021443088,0.001281849,-0.051143542,-0.08030135,-0.057390563,-0.07158202,-0.04804599,0.032182943,0.029270556,0.08827006,-0.018727258,0.05557554,0.0736373,-0.008347091,0.06550536,-0.052735854,0.015247543,0.07401714,-0.01873654,-0.023145538,0.007841628,-0.022833858,0.04649027,-0.022891974,0.017010007,-0.022794249,-0.002635519,-0.080888405,-0.038732592,-0.041496184,-0.003698218,0.0930213,-0.007081893,0.019676574,0.02195582,0.09581777,-0.053574454,0.04305378,0.09259141,-3.98276e-08,0.043589797,-0.08490531,0.064226046,0.027129026,0.02647339,-0.03763528,0.06276257,0.021275528,0.046005268,-0.02624684,0.0036095057,0.07830923,0.040926825,-0.021313895,0.08367013,0.038320843,0.07841922,0.031864095,0.01379331,0.04217541,-0.066954434,0.009400979,-0.0763311,-0.049225036,0.02068858,-0.08930714,0.0041865604,-0.022116171,0.03552542,-0.018169902,0.06744933,0.018988831,-0.06555003,-0.087883234,-0.056648634,0.03311878,-0.061230566,-0.039009783,-0.015216045,-0.064295925,-0.025114682,-0.06415924,-0.023707267,0.018427039,-0.00941811,-0.024928685,0.04662124,0.013480233,-0.0011332209,-0.043780576,-0.018593514,0.03521339,0.122657195,-0.14049415,-0.13861494,0.04545164,0.064380854,-0.042462092,-0.015387581,-0.09212848,0.0020798594,0.0055024186,0.17534284,-0.049486365 +1.14.14.51,"A cytochrome P-450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of (-)-carvone, which is responsible for the aroma of spearmint.",384,1.0,-0.0868647,-0.015504675,-0.029673127,0.003869259,0.06802938,0.047360558,-0.04572367,0.09536628,0.024800656,-0.02848608,-0.0032165386,-0.031601485,-0.06264959,0.013984918,-0.035976414,-0.0012962248,-0.026040435,-0.011628628,0.024644377,-0.11256353,-0.00134247,0.02671015,0.060722332,-0.0014351023,-0.03991893,0.008747502,0.047494497,0.08622927,-0.017188292,-0.0034375626,0.0147102205,-0.07984231,0.0030771664,-0.037520055,-0.07536854,0.07746309,-0.056288134,-0.05107308,0.06952771,-0.017258117,0.10809907,-0.039238937,-0.11594706,0.018039811,-0.026312713,-0.031059438,-0.012029185,0.012058581,-0.043323763,-0.03958349,0.008811737,-0.060038697,-0.071383834,-0.003455055,-0.06265967,0.0105918255,0.0112435315,-0.021076126,-0.0016541238,-0.010401669,0.0014637508,0.036662,-0.07477426,0.027310342,0.011324259,-0.049211726,0.005193941,0.04766384,-0.0036705409,-0.08885831,0.0042567444,-0.09595227,-0.101245835,0.04404374,-0.05542046,0.097459584,-0.027686905,-0.047158703,-0.038381867,-0.035422727,0.045430437,0.019084653,-0.0033785736,0.124395095,0.101776056,0.01412468,-0.03850684,0.0647832,-0.060612716,0.0076384265,-0.013611749,-0.044497926,-0.07032078,-0.009953968,-0.08735142,0.042567324,0.025053749,0.038521804,-0.041333273,-0.029547315,0.016872924,0.07563896,-0.08288615,-0.110643156,-0.04558979,-0.006344549,-0.01645568,0.07014539,0.04647492,-0.060637377,-0.05860382,-0.03036326,-0.04740269,-0.023268597,-0.014606831,0.08489801,-0.033464458,0.0057326904,-0.03190804,-0.006902856,-0.014437602,0.008736974,0.024660043,0.0025244474,-0.008217335,-0.012822724,-0.06391271,-1.5031126e-33,0.014960025,0.029855508,0.010282195,-0.036731638,0.021219024,0.009230168,-0.04319436,0.05896481,-0.027972544,0.024332056,-0.019045243,-0.05300863,-0.027904404,-0.037867144,-0.007191386,-0.02428631,-0.026916465,0.07399317,0.011315253,-0.03331651,-0.046894778,0.04138711,-0.046509918,0.023740927,-0.022036277,0.047868308,-0.047110945,0.023140308,0.00037089575,0.019496337,-0.07641212,-0.059702598,-0.059257176,-0.084086135,0.014347264,-0.07215213,-0.037708364,-0.06351023,-0.05267697,-0.011439055,-0.02401397,-0.033239774,0.0145225795,-0.034017645,-0.0092711,0.024693012,-0.10544945,0.04587078,0.027292976,0.046731472,0.070850745,-0.08195586,0.13574557,0.09880649,-0.058908578,0.09623684,0.013070198,0.019754784,0.01620642,-0.014216513,0.14838518,0.050764386,-0.0032249128,0.053250495,0.015184662,0.06731126,-0.06709389,-0.042617306,0.010726255,0.18874352,-0.034326434,0.04256407,0.0311886,-0.015834142,0.07536588,0.023450932,0.024057355,0.08089788,0.08939563,-0.039281536,-0.050314467,-0.055993,-0.019279916,0.005182166,0.008573084,0.024527242,0.021199718,0.02056301,-0.0051882924,0.023163961,0.05249366,-0.07440805,0.0022275285,0.00036655326,-0.054483216,4.0030404e-34,0.04044297,-0.013944172,0.03916259,-0.07201975,-0.038716983,0.078049265,-0.027581796,-0.035776578,-0.0668619,0.013110264,0.078401856,-0.028500883,0.007081466,0.010379747,-0.011866843,0.01991077,0.020163449,0.035803765,-0.012205391,0.007331565,-0.0081567615,0.031067321,0.062272843,0.03248436,0.02765104,0.030051623,0.023875272,-0.011171628,0.06330046,0.047398396,0.0016710197,0.08849774,-0.030614104,-0.064642556,-0.030493768,0.08163133,0.054735515,0.01842658,0.019368263,0.08687487,-0.024773272,0.029312707,0.058518197,0.119817734,0.0045719133,0.07633066,-0.08655355,-0.024936963,-0.022269804,-0.009621746,0.06132132,0.05910236,0.012162719,0.053620286,-0.044684883,0.015139729,0.020367704,-0.031680033,-0.011724912,-0.09319654,-0.01953234,-0.043776438,-0.03850657,0.036179733,0.020737527,0.003114492,-0.06195576,0.05260236,0.028033085,0.026152493,0.075699925,-0.013428668,0.03340877,0.07148801,-0.054224964,-0.034448538,-0.011611719,-0.03514111,0.049614917,0.001910023,-0.027465275,0.025273645,-0.08377938,-0.07539666,-0.0928699,-0.11265544,-0.023859315,0.12846488,0.04491622,-0.019007465,-0.0028261144,0.08689594,-0.030191394,0.07396488,0.029105207,-3.0658043e-08,0.009110201,-0.109862246,0.034896053,0.032534096,0.008406486,-0.0022362855,-0.026036795,-0.0039868434,0.046027992,-0.0018543913,0.010715113,0.03822727,-0.004106216,0.0064700413,0.011680906,0.043230105,-0.0018868118,-0.019296136,0.014986469,-0.04092239,-0.04178853,0.04892713,-0.05827847,0.0014953574,0.06113045,-0.059973434,-0.05903159,0.049744274,0.008419853,0.027746772,0.08215496,0.042317383,-0.011397425,0.015454823,-0.009194827,0.085076906,-0.04261696,-0.03977616,-0.041826766,-0.054081853,-0.040142793,-0.05762041,-0.06714081,0.029655555,-0.015055178,0.014772347,0.09964918,0.071079634,0.017377242,-0.01522166,-0.059343852,0.03476672,0.0049357237,-0.06732131,-0.10471157,0.017967016,0.029745173,-0.05099591,-0.0077983285,-0.10999918,0.076913334,0.046696946,0.19116506,0.0111974655 +1.14.14.52,"A cytochrome P-450 (heme thiolate) enzyme. The enzyme, characterized from the plant Perilla frutescens, participates in the biosynthesis of perillyl aldehyde, the major constituent of the essential oil that accumulates in the glandular trichomes of this plant. Some forms of the enzyme also catalyse the oxidation of (-)-perillyl alcohol to (-)-perillyl aldehyde.",384,0.99999994,-0.060611762,0.032389104,-0.042127516,-0.040722076,0.10582796,0.096651554,-0.05732001,0.09087654,0.025892394,-0.022110738,0.015318245,-0.059665367,-0.07547415,0.006880581,-0.07080363,0.059984814,-0.07390052,0.016276596,0.0264967,-0.10960832,-0.010866459,0.04780471,0.007869977,0.022029134,-0.01590234,0.03591111,0.0010138612,0.06168769,-0.021071473,-0.051092803,-0.032246064,-0.001027209,0.036879756,-0.007559595,-0.0010645262,0.09497997,-0.067156404,-0.026378192,0.0036701732,0.00983927,0.05840107,-0.076095425,-0.09470155,0.034789104,-0.027728887,-0.010914801,0.031022346,0.058344226,-0.026614184,-0.06634574,-0.002730307,-0.06402595,-0.071761124,0.009211673,-0.039513603,-0.012193659,0.026880464,0.027704189,-0.06979529,0.00066398433,0.015501071,0.028263215,-0.068125166,0.04355374,-0.010878456,-0.039460387,-0.0044806506,-0.039105047,-0.029282862,-0.07458544,-0.0355616,-0.10726903,-0.058402665,-0.021877289,-0.05409058,0.049783863,-0.06445796,-0.011944789,0.012100568,-0.032617442,0.033758678,0.030108644,-0.013744226,0.092885196,0.082230456,-0.03253488,-0.022717778,0.02223727,-0.019077433,-0.011232068,-0.017186716,0.0021004076,-0.1112434,-0.0099799335,-0.08140571,0.12865885,0.026171628,-0.008611944,0.015682884,-0.017269101,0.02321009,0.06311577,-0.05905629,-0.10542234,-0.058930762,0.015222375,-0.054513257,0.035981476,0.08306574,-0.042668216,-0.090770744,-0.0265905,-0.004061442,0.006774196,-0.0064103086,0.07265744,0.03121402,-0.04982136,0.024643887,-0.02574301,-0.057029307,-0.006483791,0.010861328,0.049811795,-0.0016181804,-0.006968382,-0.05268358,1.111651e-33,0.06405827,0.019871932,-0.054552425,0.014090488,0.002235984,0.019314745,-0.047630787,0.036676534,-0.050017677,0.012611359,-0.033799935,-0.07005908,-0.02924375,-0.0248032,0.0025661078,-0.013594236,-0.005655446,0.047632236,0.07624986,-0.022725407,-0.02028856,0.037974726,-0.099541195,0.0045249886,0.03349935,0.13706475,0.031180562,-0.011500903,0.0025153633,0.0025354149,0.0121421255,-0.045266643,-0.029282374,-0.090045504,-0.0012690495,-0.015585699,-0.050229207,-0.014664473,-0.047537897,0.037236493,-0.036116,0.002497188,0.069621965,-0.08399373,0.017690957,-0.019751824,-0.12232523,0.102959886,0.023401286,0.055035546,0.08142594,-0.033318523,0.10967753,0.0696178,-0.08910238,0.06206675,-0.020285534,0.043450058,0.007545631,0.050621867,0.079178795,0.06512788,-0.06504996,0.042570937,0.06251584,0.012859946,-0.07564233,0.011291021,0.022777678,0.15839158,-0.04304861,0.018459614,0.06509075,-0.03823053,0.036921132,0.0033055753,-0.0068922057,0.077691935,0.033574052,0.013728184,-0.017909473,-0.020730892,0.054198552,-0.066402845,-0.009059237,-0.009937123,-0.009329569,0.009719281,-0.01913128,-0.0007135415,0.05406559,-0.06230237,-0.018093321,0.021718385,-0.01579754,-1.7265696e-33,0.055689957,-0.06092426,0.039888352,-0.09428237,0.00903532,0.056066584,-0.034342505,-0.014657676,0.0027708793,0.036253244,0.045538936,-0.03969916,0.011774269,-0.0075445846,-0.014618383,0.004855604,-0.027825776,0.06952144,-0.020366346,0.029052917,-0.041620433,0.06564434,0.044779457,0.028862175,0.031298544,0.002261127,0.014182757,0.028183918,0.022929508,0.045822795,0.009685358,0.031903047,-0.057999473,-0.04976744,-0.04196187,0.022062453,-0.033518218,0.037300244,0.033961523,0.087607205,0.005181937,0.05647542,0.013093264,0.025981445,0.044035114,0.07162491,-0.10090688,-0.028671404,-0.00015044444,-0.053218883,0.032366987,0.02837864,0.028298408,0.040278643,0.00826365,0.029008076,-0.00781299,-0.036101118,0.014682444,-0.0997415,-0.04868062,-0.053621735,-0.022316331,0.03766532,-0.008451402,0.04070828,-0.070797235,0.040160492,0.034345087,0.027324686,0.07141744,0.022976821,-0.023958173,0.09476737,-0.038137708,-0.014648527,0.052311894,-0.011879606,0.04563078,0.051117327,-0.004785095,0.016958417,-0.058983963,-0.09219405,-0.05929841,-0.13137007,-0.037216727,0.12545735,0.038627468,-0.034366794,-0.03638806,0.12482083,-0.05848795,0.054562457,0.08201253,-3.8222446e-08,-0.045890518,-0.08908326,0.041125648,0.03015591,0.05255601,-0.032686528,0.05444924,0.039149523,0.04516892,-0.0064575155,8.287291e-05,0.045692544,-0.00751531,-0.019284593,0.021987472,0.041124035,0.06979489,0.0071297586,0.016832417,-0.009824575,-0.056486145,0.032300454,-0.030727942,0.016322669,0.029619882,-0.079130806,0.020985406,-0.0036950293,-0.0030285518,0.08050358,0.01975602,0.083379544,-0.03165458,-0.018803367,-0.028737841,0.054566834,-0.00356067,-0.046661433,-0.06308974,-0.007221443,-0.009190484,-0.06635457,-0.039747525,-0.025927225,0.0034344268,-0.04814832,0.045343272,0.017981125,0.0087616835,-0.005659881,-0.010507259,0.01660034,0.016627248,-0.07852739,-0.07569493,-0.006910649,0.07163328,-0.05375702,-0.054940123,-0.11559224,0.04267235,0.053989124,0.2643667,-0.025515165 +1.14.14.53,"The reaction is stereospecific with over 95% yield of (+)-trans-carveol from (R)-limonene. (S)-Limonene, the substrate for EC 1.14.14.51, (S)-limonene 6-monooxygenase, is not a substrate. Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds.",384,1.0,-0.080465235,0.017093826,-0.09355858,-0.023236506,0.03639882,0.0711588,-0.10739333,0.011180305,0.034874678,-0.016181452,0.036861766,-0.11278555,-0.091447026,-0.04864442,-0.048148047,-0.03738118,-0.041681074,0.015093232,-0.0105460435,-0.01619234,0.01787858,0.0026278838,-0.00038321878,0.037216187,0.007743614,0.01036766,0.027065912,0.010611204,0.01771879,-0.0235445,0.024260063,0.03118751,0.07687218,-0.022762584,-0.07236821,0.015270962,0.011774426,-0.06817317,0.10467517,-0.008562148,0.02311837,-0.06366121,-0.05308587,-0.105834164,0.030178044,-0.09065239,0.019014584,-0.0046742796,0.05844736,-0.09628789,0.03889881,-0.037716694,-0.020625422,-0.06627163,0.018947128,0.0386217,0.0017598546,0.004959623,0.010272428,0.032979224,0.04860484,-0.012853087,-0.07142156,0.05543776,-0.11732327,-0.028214134,-0.010923525,0.01805669,0.026124055,0.00010140769,0.003553056,-0.10755663,-0.012873378,-0.024857402,-0.009191215,0.13691203,0.057327498,-0.062044628,0.042987477,-0.052966323,0.03234316,0.0019234412,0.015046087,0.0021451814,-0.03915574,-0.0141795,0.023978649,-0.02957249,0.07414099,0.06815362,0.028632803,-0.020237442,0.010219183,-0.015032174,-0.0045317723,0.030005518,0.103043176,-0.039411765,0.049465325,-0.030783566,-0.012676315,0.11663966,-0.03957084,-0.062231507,-0.05301927,0.07285134,-0.027939202,0.11087494,0.019972512,-0.051418826,0.028658701,-0.042676773,0.06655338,-0.023619568,-0.07625137,0.067290165,-0.002963351,-0.035837583,-0.031082964,0.029866973,-0.013789366,0.00031331793,-0.007540714,0.006329805,-0.008311419,-0.011880394,-0.019812906,-7.834905e-34,-0.003078028,0.046799988,0.014586858,-0.026256287,0.09932698,-0.011763715,-0.10373614,0.013681409,-0.028527278,-0.066543475,-0.11056085,-0.03560843,-0.03454421,0.0083381,-0.0383536,0.03358095,-0.049162097,0.014036604,-0.021163898,-0.02319437,-0.069748625,-0.031176433,-0.07291705,-0.02342999,0.019337466,0.033843197,0.02283277,-0.040577803,0.0037229941,-0.010176603,-0.06682238,-0.013354405,-0.0060299737,0.027258404,-0.0073074037,0.0023269395,-0.022759376,-0.035028838,-0.035367616,0.035152122,0.06466179,0.04506356,-0.018240282,-0.023316205,-0.00874235,-0.052201837,-0.021607155,0.084206104,0.09311946,0.13095152,0.048957694,-0.010633595,0.057069223,-0.0094170235,-0.022514,0.117692016,-0.069154136,0.047657806,0.09346271,0.0063983425,0.029091232,0.094026096,0.027025247,0.014883279,0.05645748,0.084378935,-0.15199423,-0.041418545,-0.05536847,0.059120074,0.0044379584,0.026596453,0.0137668215,0.0048322,0.10066428,0.019512992,-0.0021855917,0.011488447,0.018717255,0.025886813,-0.067160375,0.06614886,0.027887931,-0.04366838,-0.029445598,0.041630317,-0.06131402,-0.017275788,0.0066116014,0.09296289,0.023482675,-0.094707854,-0.0366515,0.005301711,-0.026402486,-1.1092601e-33,0.046780486,-0.055528436,0.032380044,-0.072606236,-0.00035571732,0.070532024,0.0064836647,-0.0551649,-0.018587882,0.005728681,0.032531954,0.07112329,0.08399575,-0.019820195,-0.026790474,-0.022501515,0.05847157,0.052157197,-0.06738508,-0.014434941,0.013497794,0.03753964,-0.020450702,0.071941495,0.063362785,-0.055359755,-0.029966803,0.04302896,0.03579976,0.022331936,0.117185794,-0.027052501,-0.005336669,0.061083503,0.040928356,0.15351571,0.014530919,0.03994566,0.024708629,0.06694293,-0.08732889,-0.058403235,-0.032809105,0.0444903,0.06675701,0.017838823,-0.030482102,-0.045682907,-0.010123202,-0.033430856,0.01084758,0.07424027,-0.05772743,0.04168329,0.031184494,0.03469579,0.04138793,0.0062933834,0.0037425088,-0.063634366,0.0067443047,-0.036602356,-0.024612028,-0.049919337,0.047284897,-0.0023230414,-0.04999637,0.035724606,0.04080847,-0.08364199,0.15660031,0.021013884,0.009173892,0.03984381,-0.049378328,-0.048382074,0.020980503,-0.07563139,0.0028071383,-0.030758554,0.05486866,-0.0357019,0.06466629,-0.0017877861,-0.096599944,-0.046456553,0.027880372,0.014412082,-0.004562607,0.06306745,0.009493594,0.007957422,-0.07587107,0.064722404,0.10311409,-3.719611e-08,0.06466755,-0.07834924,0.055817407,-0.016705815,-0.046985853,0.057709705,0.0073813125,-0.015803082,-0.037901077,-0.07131768,-0.04233657,-0.03152969,0.011338663,0.005275053,0.010870088,0.000837815,-0.024578098,0.044047106,-0.038697656,0.0019325588,-0.07287518,0.008008329,-0.09201485,-0.050820567,-0.004325389,-0.15526953,0.019291842,0.02979784,-0.0058360766,-0.086098015,0.027265945,0.03462036,-0.06648826,0.05837617,-0.018232102,-0.009972654,-0.029493779,0.035452735,-0.004910492,0.001700202,-0.014051433,-0.07052379,-0.049676005,-0.011422376,-0.03238388,0.09304807,-0.0017140653,0.048877332,-0.030518623,0.030644346,0.08107693,-0.013484016,0.06068891,-0.02841935,-0.046686254,-0.016019678,-0.029059669,0.002059868,0.009145317,-0.023108725,-0.054913666,0.07386553,0.1508195,-0.020458814 +1.14.14.54,"This cytochrome P-450 (heme-thiolate) enzyme, found in Aspergillus nidulans, is involved in the degradation of phenylacetate.",384,1.0,-0.074953966,0.07345723,-0.075552136,-0.018127209,0.08406012,0.01016421,-0.054758184,0.08403141,-0.02244933,-0.040225934,0.008973185,-0.016514832,-0.03417041,0.07950166,-0.09289747,0.026466055,-0.0101488875,0.008825151,0.012273323,-0.08127066,0.0014450457,0.09356466,0.04170759,0.036032263,-0.0028510224,-0.008972922,0.08469197,0.031234344,-0.053155605,-0.06664169,-0.060549524,0.007876652,0.028226323,-0.024215797,0.022154653,0.11555652,-0.106780715,-0.032163687,0.017352413,-0.021362718,0.030072356,-0.043413445,-0.06868789,-0.037058033,-0.055242218,-0.032540057,-0.048523497,0.016317718,0.041608945,-0.031234093,-0.02063477,-0.019424312,0.029674303,-0.0027608809,0.03562229,0.023382585,0.0019430835,-0.08540992,-0.060566485,0.004944517,0.0128041785,0.048971083,-0.059262823,-0.007725423,-0.034538288,0.0096543105,0.050794456,-0.06653973,-0.045590788,-0.08980745,-0.04341041,-0.10267114,-0.02279153,0.006488929,-0.019618163,0.056517597,0.0033211564,-0.026900362,0.02068904,-0.025412166,0.08244876,-0.0007497781,-0.001179997,0.023690857,0.05493065,-0.016587904,-0.026555298,0.040828105,0.017784595,-0.042972237,0.0029473985,0.10047919,-0.041042157,0.0007108383,-0.09534036,0.05755928,0.0105701005,0.096584134,0.008926554,-0.010406879,0.06267896,0.040560734,-0.009473246,-0.060840845,-0.073930144,-0.018952558,0.039431162,0.11955901,0.09855987,-0.038493652,-0.021836156,-0.031744055,0.013589596,-0.04326475,0.037150204,0.06963609,-0.00944926,0.031000467,-0.039326478,0.0053349547,-0.032192618,0.001475391,0.0029705665,-0.01997778,-0.016936397,0.03208731,-0.061310407,1.3792283e-33,0.062248968,0.026283469,-0.051286332,0.0028885554,0.020830996,-0.0024962837,-0.046861753,0.018166753,-0.023558088,-0.11441347,-0.04807108,-0.06400532,-0.09276369,-0.013908642,-0.031421002,-0.0056075184,-0.01347152,0.027288906,0.04694133,0.030748919,0.010685353,-0.014638273,-0.058774583,-0.0009600181,0.019719329,0.092725806,0.0074801743,0.017177943,-0.007666406,-0.024089098,0.005325029,-0.072809994,-0.08097249,-0.062456705,0.035807718,0.0027415778,0.00027403253,0.03279559,-0.08269069,0.02878554,-0.052551255,-0.020862631,0.034143943,-0.081676655,0.024486022,-0.029389476,-0.10565415,0.06732551,-0.01669055,0.038007785,0.07464694,-0.03343879,0.08935755,0.07370353,-0.031586684,0.022906603,0.030226817,0.0109413555,0.0543886,0.010703018,0.10658017,0.04699355,-0.017167883,0.07173838,0.07353912,0.0217166,-0.059250586,-0.018351922,0.00011522587,0.10233623,-0.051650554,0.03170264,0.048601016,0.0035443043,0.052892745,-0.08729886,-0.041203752,0.049144607,0.03455543,0.0099711185,0.052804656,-0.016959127,0.009305324,-0.00093902834,-0.04199739,-0.0018658456,0.057517983,-0.014562846,-0.033200357,0.055912655,0.019407628,-0.11806161,-0.013938374,0.011684018,0.03226468,-1.9427211e-33,0.11976019,-0.06586792,0.041278478,-0.0531349,-0.0681103,0.057117578,0.02936153,0.05765083,-0.06784864,-0.048110217,0.09309674,-0.014978346,0.04059347,0.044440355,0.012623755,0.020388741,0.0041751014,0.050041184,0.012452744,0.008849507,-0.02372573,0.03149494,0.0050864583,0.032764174,0.056836277,0.022720277,0.0015332929,0.0011884313,0.053646598,0.006821562,-0.08086087,0.1020578,-0.056977652,-0.02148781,-0.050190713,0.08689845,0.02760543,-0.0123674655,0.0009841971,0.029751156,-0.028974283,0.04128136,-0.01988375,0.06190291,-0.011275006,0.116378196,-0.038222943,0.00082656316,-0.0044304742,-0.08317856,0.043729268,0.07456004,-0.03377941,-0.0016567204,-0.030292392,0.019330792,0.008908626,-0.012175277,-0.012164296,-0.08509815,-0.098673895,-0.028004427,-0.02156514,0.070114285,0.037419517,0.07118597,-0.047188062,0.05152637,0.09096083,-0.022337608,0.037476573,0.020761669,0.04709301,0.053779442,-0.00877162,-0.01165806,0.004507741,0.040683895,0.046721045,0.019275444,0.036601994,-0.0822123,-0.033925198,-0.07142403,-0.06641399,-0.17040099,0.0033782246,0.09285386,-0.037901856,-0.04502537,-0.03390683,0.054060016,-0.08436241,0.035489295,0.040289517,-2.8628994e-08,0.023667676,-0.056517072,0.014099926,-0.05383127,0.060757514,0.008843003,0.077524915,0.008694305,0.088754565,-0.031636495,-0.05902752,0.06771717,-0.0628439,0.01578225,0.01815456,0.03642455,-0.039229408,-0.0008181316,0.054318383,0.04040347,-0.05598544,-0.008860229,-0.08632392,0.035271846,0.011327825,-0.04948669,0.047652766,0.007200333,0.047981992,-0.002401257,-0.022173075,0.0614383,-0.01890265,-0.023232581,0.058284182,0.015313533,-0.047944486,-0.043697108,-0.016270906,0.009526729,-0.046356708,-0.044920504,-0.09404625,-0.038186975,-0.027588233,-0.0338756,0.04350829,0.040136386,-0.02678684,-0.051236942,-0.03189352,0.0021897587,0.006577095,-0.0831859,-0.10266157,0.0045324517,0.13237855,-0.048491012,-0.07494668,-0.11063493,0.023195907,0.00020048284,0.19876648,0.00016633543 +1.14.15.23,"The enzyme, characterized from the bacterium Sphingomonas sp. DC-6, initiates the degradation of several chloroacetanilide herbicides, including alachlor, acetochlor, and butachlor. The enzyme is a Rieske non-heme iron oxygenase, and requires a ferredoxin and EC 1.18.1.3, ferredoxin---NAD+ reductase, for activity.",384,0.99999994,-0.057648145,-0.0036456042,-0.13327898,-0.004832044,0.15103787,0.04386344,-0.004519504,0.02696935,0.026478682,-0.04940785,-0.011630902,-0.041954648,-0.025703069,0.0037263506,-0.09849765,0.06393968,-0.072767,0.024120094,-0.051560104,0.020023769,0.008875008,0.08455868,-0.09665835,0.029718377,-0.012489328,0.0023135592,0.040759157,-0.03900634,-0.063237384,-0.082590766,0.026507853,0.038384646,0.050460875,-0.019200139,0.007962754,0.110696465,-0.04263695,-0.024503155,0.05910911,0.03883509,-0.06778086,0.038941626,0.0004278532,-0.08833785,-0.06711152,-0.065810554,-0.009434778,0.0072609554,0.04639001,0.021504845,0.039964985,-0.03336691,-0.05219204,0.013877661,0.029020274,-0.08075835,-0.055500932,-0.013543117,-0.019991275,0.01362314,0.021589613,-0.013114197,-0.011013937,0.035102308,-0.023709849,-0.07947553,0.075725704,-0.071160436,-0.018545797,-0.07325667,-0.03381128,-0.07571733,-0.04237421,0.017909914,-0.0016753383,0.020693323,0.011175333,-0.015197391,0.08519312,-0.078046955,0.010666938,-0.021237895,0.057892498,0.09526635,0.09876547,0.015962001,-0.0021813868,-0.023465188,0.08300704,0.019599138,0.058446776,0.07422034,-0.07011074,-0.051068068,-0.08172865,0.044679713,-0.045682684,0.0072719688,-0.043003943,0.035010554,-0.040812235,0.07617799,-0.055678215,-0.09788736,0.002518139,0.015764395,-0.037132073,0.113596685,0.039439358,-0.019726168,-0.0017917512,0.033242095,0.05157981,0.0005036623,0.008818446,0.0350104,0.03928667,-0.084896185,-0.08300262,0.008277823,0.013341074,0.020829426,-0.021472558,0.022240536,-0.012057786,0.016395662,-0.04419833,1.0771426e-33,0.06240036,-2.680639e-05,-0.012393715,-0.021313239,-0.054451663,-0.0094855465,-0.077094294,-0.010782462,-0.011339369,-0.08083244,-0.021139836,-0.092556104,-0.0051514376,-0.088913225,0.04816651,-0.031177165,0.025056534,-0.044478115,0.017864764,-0.014178937,-0.024691595,0.04718486,-0.10262433,0.052149683,0.03192395,0.108197585,-0.011095951,-0.017247614,0.02288833,0.008128305,0.063967384,-0.011152521,-0.12992458,0.035775278,0.03290444,-0.00043383797,-0.036287773,0.023703711,-0.0033237804,0.033150457,-0.03265459,0.055207398,-0.061132398,-0.038268577,0.07746264,-0.08741431,-0.034499757,0.1615849,0.06725027,0.10963228,-0.035482533,-0.03423415,0.105147384,-0.0133498125,-0.03723518,0.046913277,-0.033410255,-0.025960704,0.059652925,0.06008591,0.028996462,0.053609975,-0.064711586,0.06701967,0.04157881,-0.037121944,-0.03761394,-0.01639584,0.032054648,0.02775228,-0.05207607,-0.00029652278,0.066829845,0.03447526,0.021926133,-0.10588107,-0.013157942,-0.033014808,0.07714283,0.00838973,0.048375476,-0.0408766,0.046349555,-0.058689367,-0.099268414,0.006739144,-0.037496444,-0.039880693,-0.05575871,0.017283313,0.07840218,-0.055334035,-0.11236017,-0.054573625,-0.01686371,-1.6247808e-33,0.07812796,-0.10999163,0.055670764,-0.031281594,-0.053365637,0.0883009,-0.0008181507,-0.0023871043,-0.047755044,-0.047267724,0.063751824,0.048165474,-0.029622369,-0.02080262,0.0405903,0.025843425,0.0032472664,0.0032799335,0.026391951,-0.008844482,0.0062930174,0.07628881,-0.021070674,0.031213325,-0.0063017723,0.008225505,-0.07079633,0.038980406,0.12731393,0.040539056,-0.007935694,0.0039189123,-0.008414688,0.0017686631,-0.036383092,0.006783444,0.005090181,0.0378925,-0.06132258,0.0030032657,-0.012577155,-0.0088525405,-0.03894849,0.071460396,0.059840415,0.064143844,-0.08842486,0.03388375,-0.020507803,-0.05492381,0.0036982968,0.017701007,0.00033397024,0.0091260355,0.006327834,-0.030190542,0.07685017,-0.057335682,-0.0503805,0.019830618,0.009706832,0.026151633,-0.019589487,0.059995364,0.019219866,0.10748048,0.0054330477,0.117134504,0.035938572,0.0051148045,0.053880088,0.01213554,0.07530342,-0.05694939,-0.052329667,-0.07616449,0.020021535,0.024358332,-0.015975846,-0.014615404,0.02299658,0.016409917,0.03644339,-0.019010007,-0.005104368,-0.07483588,-0.03171213,0.010642269,0.015295581,0.02361757,-0.088439114,0.01053441,0.001103856,0.04962585,0.061589662,-4.0288043e-08,-0.013293511,-0.058739036,0.07093094,-0.10426129,0.04988346,0.020453209,0.023610821,0.008468117,0.03173801,-0.054797508,-0.023993278,0.12741444,0.020564035,-0.0041496935,0.058728475,-0.0009587109,0.041486427,0.026084652,-0.015594732,0.03201259,-0.08287663,0.003589081,-0.11022393,-0.011350056,0.011453857,-0.03586646,0.03024307,0.037818033,0.031971056,0.040701743,-0.012656844,0.043149043,0.021380061,-0.036967266,-0.07569317,0.03660907,-0.04223871,-0.054694016,-0.006060733,0.04256165,-0.024809638,0.040946785,-0.07107766,-0.010147743,0.064287774,-0.02689029,0.06269673,-0.032818224,0.03130006,-0.023166249,0.020305848,0.004048036,0.010846347,-0.030868541,-0.08334734,0.062631264,0.046634536,-0.07221123,0.019305905,-0.06652771,-0.01572338,-0.011406534,0.14442432,0.022859156 +1.14.18.9,"This enzyme is found in fungi and animals and catalyses a step in the biosynthesis of important sterol molecules such as ergosterol and cholesterol, respectively. The enzyme acts on the 4alpha-methyl group. Subsequent decarboxylation by EC 1.1.1.170, 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), occurs concomitantly with epimerization of the remaining 4beta-methyl into the 4alpha position, thus making it a suitable substrate for a second round of catalysis. cf. EC 1.14.13.246, 4beta-methylsterol monooxygenase; EC 1.14.18.10, plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase; and EC 1.14.18.11, plant 4alpha-monomethylsterol monooxygenase.",384,1.0,0.009179056,0.0079648,-0.11387795,-0.077094726,-0.04262561,0.011755913,-0.17453782,-0.012079941,0.04049241,-0.03355285,0.05819153,-0.035014614,-0.12228107,-0.04657375,-0.008118121,0.016126892,-0.038957432,0.032405987,0.043051492,-0.043130305,0.07243554,0.0013748416,-0.040971108,-0.027682278,0.007990116,-0.008304078,0.03886199,-0.028642742,-0.055890907,-0.119040444,0.009382676,-0.033451654,0.07273979,-0.003322738,-0.031034721,0.103204876,-0.06262702,-0.056624938,0.06354856,0.05975275,0.026165009,-0.046031024,0.006708284,-0.062835805,-0.015057006,-0.06715697,-0.028049959,0.026839301,0.023875134,-0.07416172,0.07382732,-0.031499546,0.03674859,0.018452112,-0.01268715,-0.022982936,0.003329243,0.031861123,-0.0759282,0.03695877,0.08728133,0.026839342,-0.04181025,-0.028863939,-0.068937875,-0.017764298,-0.01834457,-0.057273004,0.028399844,-0.016398944,-0.06529136,-0.040038627,-0.0023020995,-0.0036726492,-0.053402778,0.019798014,-0.0014133386,-0.048994813,0.06680349,-0.026641617,0.087883845,0.03241773,0.050858546,0.033578023,0.057900496,0.029771172,-0.028474191,0.015224879,0.030104537,0.056355536,0.09169011,-0.00075702614,0.0042947354,0.08723157,0.018028595,0.09922423,0.049424794,-0.017004747,0.025917476,-0.024587912,0.04527141,0.004694341,-0.06593957,-0.03963408,-0.027052717,0.0020223907,-0.00033569665,0.07282675,-0.0075090504,0.017155306,-0.03409342,-0.0077606905,0.053168844,0.045332607,-0.040108893,0.104319885,0.026151888,-0.07972683,-0.05832782,-0.046194494,0.023221703,0.013446093,0.047703158,-0.001769272,0.047363505,0.06968671,-0.09453895,2.7104848e-33,0.080373585,0.024321659,-0.018524582,0.0055752355,0.03529995,0.015595874,-0.00046971533,0.080036245,-0.06404719,-0.04428135,-0.04354292,-0.06563419,0.038758624,0.03433455,-0.06800475,-0.0597029,0.028672567,0.06571376,0.048146956,-0.026293708,-0.016077515,0.025954776,-0.067585304,-0.014964283,-0.046369556,0.035409328,0.007978967,-0.049901888,0.09180231,0.009265538,-0.031001145,-0.12079796,-0.043384213,-0.007824053,0.07231886,-0.008910586,-0.038481094,-0.02576341,-0.050833326,0.0819894,0.07111095,0.028893162,0.01628614,-0.06860933,0.038142804,-0.014315995,-0.04530688,0.07858204,0.06493384,0.09376217,0.039046615,0.059713326,0.048272673,0.028359396,-0.020594144,0.04445916,-0.07667469,0.025820065,0.036333676,0.014010849,-0.036395594,0.07933681,-0.061743632,0.0016139484,-0.0012231977,-0.025647333,-0.090337716,-0.052197073,-0.094661586,0.09645855,0.018246505,-0.075320534,0.015562497,-0.019368822,0.055647627,0.015197069,-0.010181225,0.05481866,0.027371231,-0.0737627,-0.039082285,0.090799876,-0.0031338173,-0.12019987,-0.064148046,0.05121937,-0.027832368,-0.03960796,0.013286947,0.058471087,-0.02838377,-0.023400396,-0.06491132,0.0012420194,0.029756436,-4.104974e-33,0.09355781,-0.07370537,0.01724809,-0.085086524,0.033637665,0.06226108,0.01966887,-0.062184993,0.068374164,-0.032509938,0.04350843,0.060952995,0.050023664,0.0048146946,0.099993646,0.025451943,-0.026377376,0.04250036,-0.028651047,-0.025443861,0.030403776,0.09090915,-0.014722151,0.13223913,0.023006,-0.04402363,0.037717734,0.014232527,0.04627928,0.05875275,0.018252896,-0.04337545,-0.02370807,0.06259291,-0.0867426,0.04123686,-0.08340557,-0.018325515,-0.0047125206,0.073583044,-0.051002193,-0.010403851,-0.040240966,0.01564318,0.06662762,-0.0022185594,-0.071266964,0.06954051,0.056378726,-0.017577993,-0.04884788,-0.033944126,-0.006265916,0.041873842,0.017742319,0.042853393,0.014085536,-0.038943782,0.04757284,-0.0241422,-0.01211756,-0.016718099,0.031891458,-0.027647184,-0.009837938,0.023321463,0.024340147,-0.048148297,0.04033719,0.004812655,0.07719626,0.06556585,-0.07630919,0.05000772,-0.017350994,-0.025151275,-0.0420203,-0.048451703,-0.062521346,-0.034962233,-0.0051119984,0.023892494,0.08756619,-0.087923646,-0.057171695,-0.11824844,0.052180655,0.09067982,-0.028496392,0.031040888,0.0074722352,-0.010789862,-0.050899677,0.068124555,0.039733045,-4.3571017e-08,0.0025510609,-0.032926995,0.024985462,-0.04773008,-0.099016026,0.012219641,0.06408414,0.011771864,0.057687864,-0.08244191,-0.013733893,0.08468986,-0.008776916,0.02727732,0.08098072,-0.017113073,-0.042938598,-0.004305407,-0.036103234,-0.009681535,0.0014668611,-0.005455216,-0.0650715,-0.022682076,-0.009748,-0.007453138,0.0009957018,0.04452837,0.038914066,-0.0034935437,0.032835286,0.10176627,0.07878439,-0.011395633,0.0036450522,-0.0060849185,-0.026646806,-0.014894939,-0.04807934,0.077357806,0.05462851,-0.09029738,0.013498155,-0.008788257,-0.053484403,-0.02067348,-0.019469293,0.047257345,0.028134031,0.030250523,0.0030846363,-0.0025629387,-0.032534033,0.01631065,-0.04446047,-0.0260473,-0.085241504,-0.107913464,-0.012355172,-0.050054528,0.012530615,0.016686415,0.17911549,-0.00071850285 +1.14.19.52,"This cytochrome P-450 (heme thiolate) enzyme, which has been characterized from the plant Arabidopsis thaliana, catalyses the last two steps in the biosynthesis of camalexin, the main phytoalexin in that plant. The enzyme catalyses two successive oxidation events. During the first oxidation the enzyme introduces a C-N double bond, liberating hydrogen cyanide, and during the second oxidation it catalyses a decarboxylation.",384,1.0,-0.09181819,0.017048392,-0.08776474,0.006933699,0.097966634,0.042806566,-0.05713249,0.09453944,0.029066058,-0.019727798,0.034981005,-0.027264513,-0.079828225,-0.0038668753,-0.038261116,0.02811453,-0.09242427,0.046972558,-0.022004947,-0.094662584,0.023112036,0.048304494,-0.017424474,0.029555388,0.02894479,0.0062539666,0.04592429,0.050172504,-0.034806155,-0.030358355,-0.059302308,-0.050399758,0.05079299,0.020620752,-0.05447791,0.10850455,-0.05921324,-0.104568064,0.06285542,-0.018971818,0.003712918,-0.014160429,-0.097658366,0.009264603,-0.025632337,-0.008497439,0.01698636,0.004118405,0.0021312619,-0.10835142,-0.021409389,-0.018880876,-0.052219905,0.001534237,-0.04018896,-0.0006870027,0.010033377,0.00073430786,0.04064113,-0.0066009792,0.004976988,0.004618066,-0.013226388,0.020288728,0.039370038,-0.049776435,-0.030553399,-0.02413266,0.01838838,-0.099316254,-0.04822397,-0.069281,-0.05431677,0.0014390284,-0.061562993,0.095070474,-0.05157881,0.049622416,-0.011243049,-0.010347579,0.06896223,0.036133107,0.04440144,0.13011113,0.07890751,0.010467532,-0.037618678,0.06073995,0.024953824,0.009570681,0.054118875,0.082227625,-0.028322952,0.0130317295,-0.096549444,0.0681444,0.038798243,0.021497946,0.0018512317,-0.0146103045,0.022987232,0.043043595,-0.07005249,-0.071967795,0.018962895,0.010244939,-0.0032003997,0.034103103,0.072507456,-0.0701656,-0.04726536,-0.041324627,-0.019122412,-0.017520892,0.026472025,0.1267832,-0.046509154,0.012690644,-0.020811515,-0.025834406,0.017619278,-0.044066876,-0.03319229,-0.034277875,-0.08604324,-0.0013978828,-0.09686202,4.5565643e-33,0.059933014,0.06479557,-0.027491607,0.008989258,0.028931404,-0.04312886,-0.07675795,0.01860363,-0.06914634,-0.006372455,-0.056959353,-0.08765679,-0.00067715166,-0.046858303,-0.04791102,-0.037277203,-0.09695007,-0.003342839,0.047385227,0.030413082,-0.011787468,-0.04898772,-0.045230623,0.03804387,-0.0014940955,0.054662425,0.030305797,-0.009096522,0.020276515,-0.012388142,-0.004869207,-0.10064898,-0.0634478,-0.065799296,0.0056724832,-0.04637916,-0.01540369,-0.013551444,-0.08629333,0.038128585,-0.0649121,0.017414251,-0.001678503,-0.04646678,0.061647534,-0.011818839,-0.10341617,0.07025834,0.043485727,0.053194813,0.048584048,-0.018441796,0.103141844,0.017848892,-0.06649001,0.018658819,0.021576649,-0.014740508,0.025720734,0.05043013,0.08469365,0.0023653142,-0.028469078,0.031896632,0.012609602,0.09736571,-0.07132423,-0.028043592,0.008360511,0.13152836,-0.050948065,-0.01583394,0.06222087,-0.04642304,0.036344048,-0.008602788,-0.023443125,0.021461029,0.01781134,-0.009948359,-0.025847284,0.027775794,0.030433424,0.01563418,0.005456551,-0.019379064,-0.010633767,-0.021986615,-0.03846241,0.10910967,0.080142,-0.06462587,0.039853442,-0.014227182,0.0091093145,-2.6963983e-33,0.09547361,-0.013806018,-0.016174516,-0.12717283,-0.05084414,0.057036173,-0.036786195,-0.0024006586,0.041601587,-0.0118518295,0.07732488,-0.023455622,0.030866854,0.037711572,0.030987054,0.026490051,0.0323466,0.07160303,-0.005275892,0.04829943,0.019315686,0.026923476,0.003681504,-0.01707532,0.054142136,0.03862132,0.020915901,0.09442353,0.09255712,-0.026552148,0.0028480866,0.02606539,-0.026156368,0.025024015,-0.052765712,0.06173054,0.020876393,0.0028629315,0.0578768,0.071316615,-0.028361276,0.0018971217,-0.0075352853,0.08372151,-0.0014747498,0.08548351,-0.056099426,0.008388957,-0.01910291,-0.06166624,0.06689797,0.07424866,-0.07578905,0.07897065,0.009644102,0.028360443,0.008726066,0.0033983402,-0.01403031,-0.054023962,-0.0009074003,-0.033370193,0.0062967744,0.03947242,0.021052076,0.041942704,-0.043297246,0.06158226,0.0027446346,0.01668722,0.08247456,0.029475389,0.012551096,0.04020488,-0.042779867,-0.02989773,0.020160524,-0.019674009,0.009902375,0.045965884,0.024389414,0.0073142084,-0.027808085,-0.08347603,-0.032275517,-0.1194845,0.0017432988,0.16589977,0.03831273,-0.002250356,-0.024494471,0.00884922,0.007646513,0.08235624,0.09697713,-3.853184e-08,-0.048322503,-0.10809764,0.0069908607,-0.021577287,0.059689157,0.060833614,0.037522126,0.030798392,0.041438602,-0.09113074,-0.0010058343,0.051375274,-0.006002111,-0.018953566,0.03132407,0.023369279,0.00084243185,0.051819272,0.03141109,0.025930084,-0.04886368,-0.00092255994,-0.100664414,0.0072386665,0.023196284,-0.06414758,-0.0011531133,-0.036471654,0.020092377,0.00259814,0.0011194643,0.060624033,0.01676896,-0.023583798,-0.04249013,0.022655612,-0.05586076,-0.038301934,0.0012632755,-0.06295748,-0.004862122,-0.07854628,-0.102759324,0.003954647,-0.0071001756,0.00038178824,0.031262584,0.01016458,0.0067029297,0.0097032655,0.015817089,-0.013394116,0.06520982,-0.07454338,-0.094961114,0.028536394,0.07453758,-0.023472808,-0.07946818,-0.09603921,-0.012962077,0.010004816,0.24065354,-0.02890048 +1.14.99.58,"The enzyme, characterized from the bacterium Pseudomonas aeruginosa, differs from EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin), in that the heme substrate is rotated by approximately 110 degrees within the active site, resulting in cleavage at a different part of the ring. It forms a mixture of about 70% biliverdin-IX-delta and 30% biliverdin-IX-beta.",384,0.99999994,-0.05647823,-0.025050089,-0.08278775,-0.0062146424,0.062198978,-0.042264137,-0.020091629,0.113527924,0.107379735,-0.07453377,0.027636439,-0.031688087,-0.024873333,0.07020925,-0.07030576,-0.0050290683,-0.051835235,0.0051562632,-0.036563136,0.0032272574,0.020865526,0.070404656,-0.059043698,0.044577174,0.00949217,-0.0007131762,0.10588273,0.038500816,-0.00690781,-0.037323423,-0.021097688,-0.03409268,0.14428937,-0.07520938,0.031410344,0.025401942,0.012487566,-0.047462024,0.09002724,0.03787714,0.06426908,0.027492395,-0.022605335,-0.08825401,-0.023943678,-0.013496569,0.014777115,0.025150137,0.04305105,0.020010257,-0.057553828,-0.05939815,-0.046218716,0.0782034,0.017601479,0.006885151,-0.008022279,-0.05813529,0.046325717,-0.014971078,0.019365523,0.019430064,-0.00013582128,0.033889797,-0.06247896,-0.08807124,0.07817739,-0.0732613,-0.019253364,-0.05995843,-0.017654909,0.01610149,-0.056707766,0.0018093165,0.010154191,0.017487371,0.00734777,-0.058606282,0.046374597,-0.008989906,-0.026743457,-0.06969592,0.03305777,0.07825778,0.00860785,-0.019482987,-0.0037297506,-0.007311153,0.014698966,0.0003798471,-0.005124393,0.04453275,-0.06543709,-0.09704487,0.02488925,0.05737871,0.0187817,0.0809224,0.027363474,-0.022371303,-0.05137904,0.06978283,-0.00876212,-0.101049125,-0.014224877,-0.026376858,0.059566054,0.07037142,0.08705152,-0.034633905,0.047870457,-0.082306914,0.105836436,-0.062159408,-0.0024033538,0.078425,-0.002263915,-0.006393388,-0.08643674,0.111178115,0.020518461,-0.012176527,0.04311721,0.0449354,-0.011064048,0.0050799605,-0.09741354,1.08772e-33,0.06707121,0.03846558,-0.02882721,-0.0013304839,-0.043968786,-0.041770212,-0.10698713,-0.009736184,-0.03498321,-0.043930024,-0.04274259,-0.029752191,0.037069835,-0.039257906,-0.0043641133,-0.051681638,-0.01782611,-0.03436484,-0.008665981,0.019709997,0.054149795,0.015389258,-0.038423415,0.02702407,0.07433102,-0.010074459,0.045837328,0.049815718,-0.049354862,-0.0041767103,0.026812065,-0.029827313,-0.10560039,-0.040053908,0.055901196,-0.037853356,0.027443774,-0.002615489,-0.024449585,0.04663354,0.025806865,0.051195942,0.0022513333,-0.07428882,0.1579426,-0.02679237,-0.04290613,0.12071883,0.079085894,0.15658389,0.0028805668,-0.005087709,0.11253816,-0.01823551,-0.024922756,0.0025054077,-0.024186548,0.0029415477,0.08142613,0.079094164,0.049399626,0.06876091,-0.041406844,0.013359464,0.0016616443,0.043701407,-0.026650922,-0.07168077,0.019408243,0.021858344,-0.050617717,0.0140594775,-0.011831712,0.028211003,-0.0069694347,-0.08377077,-0.10522078,-0.006384357,0.09112078,-0.03166255,-0.02465389,0.020216674,0.034319844,-0.07619887,-0.09831602,-0.035072897,0.0008479221,0.023289546,-0.060599275,-0.007815753,0.08444513,-0.119883984,-0.06275522,0.0078644585,0.032205865,-1.4589133e-33,0.052961446,-0.120469235,0.0154121015,-0.033692885,-0.043193214,0.08244366,0.020788299,0.064858876,-0.0070866076,-0.017027343,0.1175245,0.022226645,-0.024859915,-0.0051596025,0.030031111,0.041002747,-0.0054026516,0.012438206,0.0030071295,-0.01658332,-0.0072116093,-0.0159116,0.0039003158,0.030341897,0.05264958,0.03589816,-0.042583246,0.061598863,0.065378085,0.063891865,-0.038542528,0.018006567,-0.029369356,-0.017748412,-0.100929394,0.07603086,0.022280995,0.011036299,0.096141875,-0.066197194,0.028388849,-0.026514156,0.012783296,0.0547098,-0.030185446,0.08208729,0.021473628,0.0123600885,0.0023755748,-0.10119309,-0.05260873,0.029010408,-0.006996839,0.011739944,-0.0536851,-0.027395098,0.0019671232,0.0756194,-0.074686624,-0.027015481,0.03222123,-0.040209677,0.07695819,0.03126042,-0.0038608501,0.08248378,0.010964701,0.021061547,0.038711485,-0.031309925,0.0395636,-0.018092692,0.011747875,-0.03566254,-0.027052494,-0.022594735,0.047581296,-0.04885085,0.012990836,0.009471022,-0.00047219574,0.008836644,-0.050038446,-0.078046724,-0.0131763145,-0.050350275,-0.021692831,0.025665779,-0.03771107,-0.0180322,-0.06358071,-0.020703306,-0.054576382,-0.032873243,0.06645781,-4.1566373e-08,0.0032303836,-0.06426255,0.06610736,-0.016893221,0.0058698114,0.02493713,0.020503968,0.00031854273,0.021127988,0.008252316,-0.018542346,0.0796168,-0.061402157,-0.057185426,0.06972541,0.013699318,-0.08150988,0.04537556,0.008955274,-0.0218395,0.011955587,-0.016546505,-0.07761631,-0.010706109,-0.020503208,-0.06149895,-0.061185677,0.009321927,-0.0054272003,-0.03485951,0.0001025765,0.037100807,0.026966877,-0.012877613,-0.084189065,-0.044299617,-0.0953963,0.01858142,-0.06365005,-0.015100169,0.060536284,-0.056705497,-0.11391102,-0.052178174,0.042088058,0.04428133,0.0771826,0.033690184,0.026594624,-0.089560516,0.052655477,-0.063477494,0.06900822,-0.011447428,-0.08136175,0.053672478,0.008470516,-0.05069642,0.035721555,0.026799846,-0.027056525,0.003122883,0.13624243,0.0019633665 +1.16.3.3,"The enzyme, which belongs to the multicopper oxidase family, is found in many bacterial strains. It oxidizes soluble manganese(II) to insoluble manganese(IV) oxides. Since the enzyme is localized to the outer surface of the cell, its activity usually results in encrustation of the cells by the oxides. The physiological function of bacterial manganese(II) oxidation remains unclear.",384,0.99999994,-0.07324532,-0.10310047,-0.04616272,0.028531946,0.114044726,-0.023928102,-0.060493413,0.079829074,-0.0024771588,-0.0134983035,0.05248471,-0.009557177,0.05192605,0.06355591,-0.047419835,0.04042926,-0.08724582,0.012528614,-0.026444571,0.008339115,0.07301782,0.005647631,-0.027004797,-0.102517344,0.06571838,0.03859094,0.05771048,-0.02403175,-0.07332793,-0.04574792,-0.030484699,-0.0038873225,0.116364054,-0.08463217,0.09412493,0.0036118592,0.02831665,-0.033104327,0.043343812,-0.028213779,-0.026968045,0.06700268,0.0853485,-0.08035734,0.012400774,-0.04462395,0.076205246,-0.043685615,0.041677635,0.04899793,-0.026515104,-0.034975808,-0.0011836037,0.027105818,0.025531445,0.021051224,-0.04725452,-0.068377145,-0.009160118,-0.009279809,0.052401554,-0.021152154,0.05366129,0.027674787,0.00045314134,-0.069268085,0.070150696,-0.03245698,-0.017029941,-0.06499272,-0.0024714922,-0.047445253,-0.0016316674,0.018893382,-0.04874811,0.0046735494,0.06964343,-0.059500113,0.023051396,-0.0036885212,-0.058569506,0.007170882,0.059022177,0.009002795,0.042487632,0.009122797,0.025350219,-0.04389207,0.02541137,0.120990776,-0.029615726,0.016878529,-0.03675987,-0.027823878,-0.10671784,-0.0520076,0.018650867,0.13106719,0.0018566943,-0.02782073,0.0020991887,0.03695336,-0.011483742,-0.114405714,-0.0018473834,-0.06361063,0.0474582,0.07281173,0.03324455,0.003818136,0.06450071,0.06564075,-0.028136317,0.031115107,0.028824303,0.067809775,0.12431924,-0.06677181,-0.102933735,0.059676223,0.0011627304,-0.041866433,0.014453527,-0.0049276208,-0.036511965,0.0008623082,-0.021639809,1.1648249e-33,-0.005134971,-0.018349253,-0.030131107,-0.0057466296,0.0051527712,-0.024275532,-0.044552032,-0.05508145,0.020168122,-0.002045533,-0.11168731,-0.009064032,0.054812223,0.0273168,-0.022790229,-0.004026647,-0.033337347,-0.030376254,0.06745415,0.061277773,0.06340127,0.012407131,-0.034662142,-0.013003637,0.025674917,0.05881467,0.07054375,-0.08338948,0.039631005,0.018319944,0.06519901,-0.07055029,-0.08908915,-0.025767231,0.11401235,0.011507485,-0.029417457,0.037179865,-0.018273843,0.02065963,-0.04491933,0.006230741,-0.09829999,0.035024036,0.052841518,-0.10712302,-0.07575059,0.093601495,0.03682438,0.0017075705,-0.023803975,-0.032614652,0.09921213,-0.023466714,0.026749583,0.027145866,-0.00030850462,-0.012577276,0.034694076,0.04435175,-0.039729506,0.015176403,-0.07617762,0.1213936,0.050658412,0.002534474,-0.0030041235,-0.07110715,0.04492072,0.04235293,-0.06083694,-0.0600256,0.037814736,-0.030024802,-0.082379736,-0.04584601,-0.05786719,0.0054062465,0.031293027,-0.017174419,0.02503835,-0.003503698,0.022974899,-0.08518416,-0.03758381,0.04429929,-0.04416966,-0.031984076,-0.01152524,0.05504414,0.14051029,-0.0042710565,-0.058521453,-0.041257024,-0.041208968,-2.7199134e-33,0.08297834,-0.07493615,0.036443245,-0.11288791,-0.097432524,0.049659796,-0.05477939,0.007805102,-0.0017408836,-0.071151234,0.027733738,-0.0011016369,0.008540557,0.015540709,0.010959392,0.027102744,0.015522605,0.06325328,0.042512454,-0.041401897,-0.013784445,-0.001406882,0.062632866,0.010732812,0.03781857,0.045835767,-0.09650966,-4.2494794e-05,-0.0056928275,0.050749917,-0.01554841,-0.01925211,0.058268473,-0.047293425,0.014168667,0.0152545925,-0.07520914,-0.040199198,0.06389755,0.029762711,0.013713473,-0.0028263135,-0.026769146,0.067104205,-0.046487022,-0.027958235,-0.08428399,0.01803621,0.03452375,-0.042352594,-0.009841972,-0.04280613,-0.058050193,-0.02007358,0.038878012,-0.0073176073,-0.00064876914,0.0135391615,-0.0141774705,-0.03729383,-0.041490894,-0.03934583,0.0398456,0.071084484,0.044646904,0.0891824,0.083594084,0.04577369,0.004881332,-0.04614376,-0.015411842,-0.0018023173,0.015692415,-0.012128189,0.012160422,-0.09343066,-0.045914494,0.05902756,-0.01159238,0.008699083,-0.0065364116,-0.004183085,-0.015804607,-0.10444208,-0.013945957,-0.08269135,0.045423344,0.14122735,0.030185293,-0.0326526,0.008846816,-0.018263113,-0.06939068,-0.024876956,0.043109722,-3.960219e-08,-0.0054155667,-0.07979457,0.06750381,-0.05356713,-0.04693019,0.0341046,-0.016803684,-0.018889682,0.083897896,0.011215361,0.071139,0.12915443,0.010639959,-0.07495669,0.08404184,0.008414515,-0.013064206,0.019693548,-0.035666715,0.03248236,-0.0089042755,-0.024209034,-0.040024523,0.07531183,0.016051587,0.039008766,-0.029706756,-0.02263571,-0.06105,-0.015773948,-0.02769568,0.042336445,-0.02774366,-0.020382099,-0.12326165,0.031023534,0.03816104,-0.018668192,-0.03782094,0.035286866,-0.08034308,-0.019847097,-0.10505614,0.010124935,0.02718166,0.017813893,-0.022556959,0.021801382,-0.024218405,-0.03464147,-0.044552818,-0.05119038,-0.0034557015,-0.017588293,-0.09947734,0.10066944,0.014231469,-0.033154216,-0.032730106,0.040074304,-0.013759651,0.03265598,0.1251604,-0.032826494 +1.17.1.9,"The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.",384,1.0,-0.03779112,-0.065495335,-0.22085556,0.030189915,0.07619404,0.020059284,-0.06617651,0.040004127,0.0022180153,-0.0334492,0.032953035,-0.08229075,-0.09260828,-0.017777896,0.024374157,-0.009561096,-0.04439922,-0.034616705,0.01611049,-0.041784115,0.064647004,0.009218981,0.008278098,0.014177677,-0.047576774,0.06935556,0.036328312,0.030608356,-0.08700678,-0.09883833,0.028540203,-0.03292176,0.14042737,-0.051512264,0.10970327,0.11266496,-0.031633146,-0.094229266,0.035788074,0.017076543,0.023884162,0.03712459,0.051003195,-0.0524501,-0.032281682,0.0050425413,0.020399256,0.027159838,0.012639372,-0.027758673,-0.022997564,-0.0909275,-0.031413693,0.05733271,0.003089498,0.05112927,-0.009031657,-0.015357257,-0.043731734,-0.03507985,0.019707646,-0.0009660063,0.023965197,0.011461443,-0.036473945,-0.0238799,0.03606056,-0.052338902,-0.008518713,-0.10723291,-0.10333293,-0.0081934845,-0.029740704,0.02020023,-0.07354525,0.0667037,0.018279698,-0.056379218,0.049816336,-0.015130239,0.03548447,0.010899242,0.07036703,0.0519997,-0.00409496,-0.003968441,-0.010112692,-0.03906914,-0.04013407,-0.00048803023,0.027718183,0.014399847,0.024806103,-0.051130064,-0.048391987,0.06512665,0.022692956,0.053260516,0.019376311,-0.06173612,0.009515347,0.059038687,0.017852949,-0.09447122,-0.015880248,0.0039547393,0.019076562,0.1246376,0.088950574,0.04055318,-0.014916377,0.006651361,0.056825966,-0.0306481,0.014776955,0.06682216,0.04797977,-0.05975435,-0.07023535,0.00088440167,0.029765239,-0.061015718,0.06521014,-0.031027772,0.028256485,-0.0148986885,-0.10859502,4.625022e-33,0.07398541,-0.01642217,0.01902126,-0.025940308,-0.02386685,-0.009091511,-0.0778747,0.0029559154,0.040667996,-0.022023547,-0.07724104,0.013196481,0.0821878,-0.029993474,-0.027351191,-0.027710881,-0.0071614515,-0.004760575,-0.010246754,0.03766152,-0.012904691,0.05752202,-0.005845289,-0.06389663,0.04823292,0.08092858,0.007599286,-0.031957865,0.021920662,0.0050030216,0.0081029795,-0.1296235,-0.12678085,0.08058209,0.086919546,0.053093307,-0.049772203,-0.022952124,-0.036752116,0.023067707,-0.033797037,0.034395333,0.016277947,-0.07311059,0.07046053,-0.051152993,-0.036183085,0.109229654,0.06663482,0.035864208,0.008840568,0.022972772,0.11366932,-0.043504603,-0.061818052,0.040769137,0.031594086,0.046703268,0.03905466,0.06678531,-0.010689291,0.09083151,-0.050654933,0.032465186,0.03227806,0.03528281,-0.0773047,-0.056329668,0.062421538,0.065268,-0.011584728,0.01030086,0.07221089,0.01592723,-0.01636373,-0.048305612,0.04672988,-0.057905555,-0.019941349,-0.0016154546,0.027417598,-0.01855798,0.011182967,-0.037856665,-0.041152343,0.027553985,-0.045065068,0.015089829,-0.042629566,0.0035023352,0.038765993,-0.06415372,-0.047684066,0.0014940387,-0.014167784,-3.5741725e-33,0.06177942,-0.03853294,-0.038706563,-0.08614527,-0.004829762,0.084608,0.05793161,0.009353517,-0.036958843,-0.013353493,0.10559427,0.0027785224,0.0072923107,-0.0593503,0.07270864,0.0745377,-0.01555689,0.056587804,0.00044717867,-0.04548595,0.044954706,0.033922367,0.018048042,0.0044270926,0.019578947,0.015089744,-0.069851905,0.047575675,0.0668025,0.01690053,-0.033989016,0.002399931,-0.03355437,-0.04119413,-0.046044663,-0.015263588,-0.072869845,0.027668186,0.011320631,-0.011220524,0.015302728,-0.016140485,-0.013456447,0.110998,0.082472555,0.06614699,-0.116895035,-0.004442926,-0.018622616,0.031042455,-0.02691466,-0.06788205,-0.030589832,0.013553262,0.05519493,0.04177824,0.0010040774,0.042188,-0.08865674,0.0025046738,-0.024110468,-0.03686433,0.049283862,0.063080184,0.0057704854,0.059829656,0.003489313,0.047690406,-0.009705129,0.029858893,0.09579677,0.024598032,-0.0448166,0.0057444265,-0.042128444,1.1953066e-05,-0.018249385,0.031718444,-0.0031714968,0.020240173,0.0475154,0.04475628,0.0027515693,-0.08790044,0.075498134,-0.039381064,-0.0157307,0.036169432,-0.020918725,0.03577665,-0.0008057127,-0.026065595,-0.03089827,0.009024226,0.02242619,-3.6898005e-08,-0.031316843,-0.0539326,0.13186611,-0.010700039,0.025980059,0.059200637,0.061623253,-0.035051767,0.014049043,0.0016023307,0.015853368,0.04691713,-0.013118364,-0.051496115,0.033368517,0.087122455,-0.048856143,0.05963724,-0.030417595,0.057972778,0.0098495595,-0.022210833,-0.13589041,0.068104826,0.022545138,-0.048285928,-0.039568815,-0.009186594,0.015485121,0.019211128,-0.009648814,0.058972485,0.049100436,-0.04460068,-0.12136294,-0.04565801,0.012669051,0.03124483,-0.15845828,0.010480862,-0.042265184,-0.028138418,-0.057498775,-0.013172305,0.028888185,-0.021327613,-0.020184638,0.017568626,0.031483848,-0.036177497,-0.01356367,-0.032044884,0.0036861324,-0.035637338,-0.11263638,0.05051378,0.012014568,-0.06785715,-0.045504432,0.019031826,0.04176632,-0.010906089,0.14444467,0.03847976 +1.17.1.10,A tungsten-selenium-iron protein characterized from the bacterium Moorella thermoacetica. It is extremely sensitive to oxygen.,384,1.0,-0.036508944,-0.0139061315,-0.07816009,0.13660428,0.0745056,-0.005037779,0.040541478,0.040251713,-0.0055065,-0.073332064,0.0066240965,-0.113533534,0.016502269,0.015560934,-0.05322655,0.0075704013,0.042291336,-0.025191369,-0.021630095,0.025337858,0.032733917,0.075533964,0.05858159,-0.05968217,0.0007468626,0.057748698,0.05667142,0.024676006,-0.03748485,-0.027417276,-0.023076972,-0.050378364,0.11692198,-0.016803097,0.08837784,0.021421736,0.024051178,-0.052709684,0.011360108,-0.01615354,-0.032189406,0.032788586,0.017891442,0.021589752,-0.073866956,-0.00021022995,0.06674754,-0.048404355,0.04145844,0.07796993,-0.0543571,-0.067338444,-0.046137575,0.06675176,7.305771e-05,-0.07448392,0.01457601,-0.03743318,-0.038750153,-0.07349164,0.030044043,-0.061231855,0.04989692,0.032875396,-0.015023924,-0.025718907,0.04335971,-0.040832423,-0.051731173,-0.056174614,-0.042008333,-0.005554159,0.0046501243,0.06326049,-0.05992226,0.07481793,0.08386574,-0.09094262,0.13506596,0.06220129,-0.07437357,-0.02112802,0.019917142,0.088016465,0.0065675704,0.039910585,0.039450068,-0.030543696,-0.04013242,0.03356159,-0.044248264,-0.018027019,-0.03154707,-0.07400132,-0.035981487,0.021405905,0.03452798,0.054980043,-0.007487198,-0.010013669,-0.0764091,0.049495757,-0.010020276,-0.048877697,-0.07330336,-0.04656979,-0.06662718,0.09048845,0.057622306,-0.028137043,0.046548516,-0.020740176,0.021179283,-0.02970554,0.006774846,0.02655173,0.028110975,0.013016144,-0.084725074,0.021309435,0.018279726,0.012338169,0.011353535,0.00808464,-0.04331245,-0.056839902,-0.07572019,-6.812196e-34,0.083211675,0.035588082,0.015704796,-0.0024610746,-0.035457246,-0.072800525,-0.07600594,-0.026293382,-0.056776896,0.0058627087,-0.07859418,-0.027487494,0.08442221,-0.046721324,0.0081845885,-0.0013620451,-0.035239846,-0.017587509,0.03766747,-0.024853038,0.035392307,0.074290015,0.10121073,-0.011095335,0.0025724308,0.0046518263,-0.011947755,-0.049021218,0.0063744816,-0.00048504674,0.042038225,-0.09637418,-0.14036031,-0.021122256,0.08182778,-0.006828077,-0.033931483,-0.015136494,-0.06566389,-0.013926957,0.046075255,0.043592773,-0.016068261,0.025511447,0.07463176,-0.09354925,-0.0149113815,0.0931437,0.051036846,0.060303763,-0.052448034,-0.027563449,0.12169565,-0.013907262,-0.057233058,-0.00040513833,0.026038783,0.032352112,0.0015524325,0.06818401,0.015476532,0.012438851,-0.017776785,0.034153264,0.04499122,0.007029375,-0.06807798,-0.0011611042,-0.013944199,0.007448023,-0.019010901,-0.0012247137,0.026336497,-0.028319495,-0.07165926,-0.050103895,-0.045769162,-0.057863325,0.03968867,0.011915783,0.035416987,-0.036100116,0.049398337,-0.105818704,-0.11158626,0.010702479,-0.041863285,0.058146372,-0.029776892,0.0057388335,0.12085994,-0.09908798,-0.056379385,-0.036135245,-0.0725765,-3.7785967e-34,0.031486213,-0.08760792,0.015693858,0.009443722,-0.04249554,0.032911677,-0.010712734,0.028052967,-0.07676706,-0.00041549103,0.1245475,-0.0022269848,0.055913713,-0.09198805,0.03890559,0.044501368,-0.008394898,0.038513828,0.0757196,0.0068965824,0.0046469304,0.04819704,-0.041058023,-0.03630084,-0.033582624,0.06351669,-0.043630693,-0.050600182,0.014435339,0.06466796,-0.0014335141,0.06360559,0.020376353,-0.059344318,-0.026911521,-0.03291217,-0.0024398658,-0.009702318,0.060505703,0.039433356,0.01323617,0.028720763,-0.016878182,0.10329629,0.08426159,0.061827168,-0.09843297,0.011122151,0.020818722,0.05275986,0.015512334,-0.054958764,-0.097288854,-0.05656049,0.014968065,0.008940681,-0.07288832,0.026892671,-0.023333754,0.005391427,0.026399933,-0.045387343,0.10063643,0.09950888,-0.0021952137,0.13274021,-0.02011632,0.027352588,-0.012343433,-0.033522755,0.007353829,0.004664717,0.013987307,-0.061398115,0.057360396,-0.074397445,0.018369287,0.041365273,-0.013214942,0.07669614,-0.024708813,0.050385915,0.021792809,-0.022587623,0.13455544,-0.02100743,-0.05894888,0.025380904,-0.022394171,-0.0243287,-0.09075938,-0.022985797,0.014177241,0.046105564,0.018838108,-2.5748816e-08,-0.023185305,-0.048952408,0.06059303,-0.056043465,0.026860304,0.023106942,0.020159772,-0.043192156,0.042923994,-0.012920435,0.041726105,0.07784032,-0.0013630716,-0.054744627,0.059502598,-0.00011271222,-0.0013465043,-0.03291511,0.0019188125,-0.03414567,0.056578774,-0.036111217,0.03947498,0.056373894,0.04796593,0.021578636,-0.027584892,-0.01970721,0.02106593,-0.09500957,-0.09890164,0.013631293,-0.037114233,-0.008776781,-0.111678086,-0.0040558395,-0.024628833,0.040354546,-0.06285579,0.07725306,0.014948095,0.0342732,-0.062454067,0.025490748,0.04681428,0.06977221,-0.005093874,0.029931976,-0.046065256,-0.046610676,0.0285942,-0.034042705,0.006331993,0.020751068,-0.14609182,0.06505388,0.03014751,-0.038174115,0.0026912896,0.046204027,-0.023639105,-0.057763945,0.07332624,-0.0299709 +1.17.1.11,"The enzyme complex, isolated from the bacterium Gottschalkia acidurici, couples the reduction of NAD+ and the reduction of ferredoxin with formate via flavin-based electron bifurcation. ",384,1.0,-0.09597785,0.055500273,-0.08925011,0.066885374,0.022489984,0.04767421,-0.1095796,0.041667357,0.022375617,-0.05915887,0.00221082,-0.007041797,-0.03857207,0.030782707,-0.06360871,-0.035748124,-0.10599717,0.05085649,0.024771765,0.025444182,0.03530551,0.003404481,0.027982142,-0.016052457,0.007305733,0.05726346,0.031098088,0.019706238,0.0044724243,-0.07383074,0.03251449,0.004626676,0.049128942,-0.06355055,-0.018700315,0.044375803,0.019237291,0.03148888,0.070237376,-0.06264332,0.002346681,0.032511324,0.014095695,-0.08945621,-0.018887226,-0.013115473,0.08284052,-0.0003034028,0.044753443,0.03948332,-0.073635854,-0.03064507,-0.03196565,0.02405598,0.09805275,-0.03529223,0.006057825,0.009122664,-0.031962015,-0.019235484,0.068794675,-0.0018175615,-0.037408065,0.061032914,-0.036635228,-0.03532447,0.05053704,-0.02543479,-0.0021464701,-0.06884859,-0.030047666,-0.015444039,0.032374304,-0.009070554,0.013924627,0.08674896,-0.026709137,-0.0112844305,0.026633296,0.06418781,0.05142391,-0.04583844,-0.002739115,0.13016832,-0.049132317,-0.028643439,-0.027403215,0.030039543,-0.002918855,0.010733737,-0.0016907551,0.061085068,0.013584204,-0.016279312,-0.08744876,0.035795838,0.07002352,0.043401908,0.01386672,0.012754041,0.034062106,0.052215282,0.002644586,-0.14873452,-0.013028055,-0.018669907,-0.03378526,0.121951506,0.012473714,-0.017609784,0.021511786,0.023761991,0.071149565,-0.0015176984,-0.02998836,0.14737597,0.03353376,-0.07169627,-0.08162564,0.0173483,0.07423308,0.010249314,-0.0051331096,0.026787555,-0.013982444,-0.00990245,-0.12285078,1.2652781e-33,0.09490623,0.001028277,-0.025753383,0.008425658,0.026588872,0.009374974,-0.08766504,0.005754928,-0.023291718,0.016464751,-0.04728367,-0.08561424,0.058211327,-0.06373514,-0.049389843,-0.049944784,-0.010142518,-0.10689615,0.010320137,0.024794621,0.079090856,0.04396571,0.022802392,0.029435566,0.057405643,0.08454553,-0.0059590028,0.03563123,0.03166693,-0.03391252,0.08357477,-0.097346045,-0.15015057,0.014298641,0.09690892,0.0056108497,-0.055923004,-0.035036843,-0.043605037,0.052768435,-0.04938216,0.04271538,-0.027331967,-0.057325494,0.14395128,-0.08299427,-0.024524134,0.12355367,0.09614703,0.14592913,0.0038963216,-0.034784697,0.086127974,-0.0007615222,-0.050121266,0.066691935,0.02095715,0.021371145,-0.026650459,0.07004893,0.026798032,0.019468881,0.035209145,0.00571735,-0.049265016,0.023545159,-0.006171191,-0.03982619,-0.01822418,0.016423184,-0.004389366,0.059865333,0.09345722,-0.022904295,0.06566588,-0.06889933,-0.07386326,-0.062877536,0.06444489,-0.019955607,0.010155063,-0.013380727,-0.00010649154,-0.029908217,-0.04749315,-0.038278084,-0.04422689,0.036259968,-0.04031484,0.009246039,0.03715631,-0.09734067,-0.052613255,-0.0581944,0.018084094,-2.3698058e-33,0.04492337,-0.08422966,0.018069394,-0.06470188,-0.05405964,0.10139918,0.014929001,0.0022969693,-0.043837342,0.00626138,0.09515035,0.023099113,0.05209524,-0.046159666,0.06928852,0.03753434,-0.005674514,0.013279856,0.07509956,0.0026084522,-0.011469837,0.048062846,-0.00856809,-0.02243352,0.09305686,-0.006257297,-0.0111297015,0.029822592,0.09049706,0.060856137,-0.03974774,-0.07008105,-0.080610864,-0.07022078,0.029529156,0.044271473,-0.06856069,0.009309569,0.013521158,0.0043842015,0.0009990516,-0.008916968,-0.065144114,0.070592925,0.09525939,0.07786543,-0.16071203,-0.012549281,0.025510618,-0.04174064,-0.00512711,-0.017387692,-0.020105075,-0.029185286,0.028076306,-0.016481217,0.03668927,0.063061774,-0.03607014,-0.00090909074,-0.024027657,-0.11544158,-0.015978301,0.028175471,-0.009378609,0.033020318,-0.035058144,0.017005336,0.010751869,-0.03392556,0.040986244,-0.036999352,0.008398402,0.048519913,0.008137976,-0.0041937996,-0.027546924,-0.016505502,-0.00979716,0.016582398,0.039425705,0.042121395,0.012618462,-0.11079636,0.041708414,-0.06824195,-0.026824247,0.03417695,-0.03181196,-0.011949785,0.005830654,0.05789637,-0.004567793,0.0008689134,0.016375974,-3.052116e-08,0.029459387,-0.063944235,0.0063745473,-0.022655483,0.020343445,0.010358141,-0.013772768,-0.033128295,-0.030738093,-0.005541544,0.0014313118,0.057030555,0.0033824164,0.0004913874,0.027337788,0.029881429,-0.01787551,0.018926242,-0.07543234,0.002890352,-0.065525725,-0.00580117,-0.18688197,0.05544665,0.0376489,-0.0391749,-0.025690816,-0.047648,0.014165119,-0.07316215,-0.045045655,0.010619303,0.04152658,-0.039139412,-0.12847768,-0.019815983,-0.040934145,0.0005288244,-0.005872604,0.01763891,-0.008074177,-0.015343976,-0.03752144,-0.00073473336,0.015898608,0.025382638,0.044820335,0.010081619,-0.002130456,0.012193063,0.054887068,-0.011693027,0.0022674864,-0.086584695,-0.10138168,0.069471456,0.008539893,0.0035623757,0.004703944,-0.01513779,-0.036205094,-0.0011814868,0.081230536,-0.016401265 +1.17.2.3,"The enzyme has been characterized from the bacterium Desulfovibrio vulgaris. In vitro, yeast cytochrome c, ferricyanide and phenazine methosulfate can act as acceptors.",384,1.0,-0.102409676,-0.02111505,-0.10158439,-0.05551427,0.002049351,0.025609843,-0.07550569,0.05512953,-0.008602507,0.02183504,-0.01792535,-0.03604193,-0.029393425,0.032478865,-0.0806159,0.01316165,-0.052121203,0.012182886,0.015282341,0.024555583,0.05510247,0.028092854,-0.006154051,-0.035370998,-0.025643477,0.058855914,0.03133332,0.05176036,-0.06220708,-0.09171699,-0.0003452055,0.00083542155,0.048885774,0.00026489314,-0.029880444,0.07947821,-0.046119533,-0.054712843,0.024415767,-0.05403168,-0.005793415,0.06075435,-0.054384835,0.036588386,-0.04381526,-0.04638282,-0.028458433,0.061120253,0.059121966,-0.07218644,-0.07459588,0.014901487,-0.006007596,0.07795883,-0.012030529,0.008486603,-0.0280028,-0.057054725,0.014865119,-0.035364237,-0.04299741,-0.01917885,0.022317342,-0.020099273,-0.0021219065,-0.0645922,0.02019554,-0.02324995,0.09064542,-0.06566014,-0.09323203,-0.06039123,-0.011143861,0.023019586,-0.048810266,0.08916759,0.03021856,-0.033815388,0.038274772,-0.036981277,-0.0060765627,-0.04966644,0.034252767,0.0756945,0.07023569,-0.02888097,-0.030437332,0.02732361,0.11518664,0.066474676,0.024083842,0.040956993,-0.015820932,-0.026032891,-0.11892757,-0.0060680187,0.05201768,0.103387885,-0.005012062,0.0011907406,0.0022233666,0.04240775,-0.0024864199,-0.09560838,-0.06620404,-0.06798554,0.040950365,0.0922519,-0.022022009,-0.036190238,-0.046984676,-0.028333638,-0.016407544,-0.012293231,0.0033639688,0.06531017,0.10423829,-0.13781743,-0.059386726,-0.098707505,-0.012465634,0.009646931,0.028533423,-0.05082191,-0.003419765,0.04408511,-0.09494032,2.9143163e-33,0.029605143,0.055154912,-0.014469138,0.0060153734,-0.06627469,0.025733396,-0.07379502,0.14253584,-0.016348355,-0.08150834,-0.07614944,-0.00044603396,0.025398277,0.03694812,-0.064304195,0.03309507,0.069690764,-0.014961469,0.0655029,-0.023100678,0.043160677,0.03268162,-0.023024678,-0.06168187,0.03337741,0.019982077,-0.04434372,0.03968237,0.032090794,-0.006814371,0.08458794,-0.14327028,-0.06315718,0.017578337,0.10094913,0.056087293,-0.0732534,0.07173284,-0.032086328,0.0107315425,-0.051381182,-0.018054686,0.0059650145,-0.021827316,0.03895332,0.008831639,-0.108201355,0.055272363,0.014292845,0.07657487,0.037150323,-0.049428303,0.08471564,-0.009548585,-0.05993456,0.09906936,0.017430685,-0.03633414,0.015383795,0.0022568472,0.03354028,0.11583076,-0.06664899,0.061368663,0.045604914,-0.03465917,-0.018788515,0.04269665,-0.0027029582,0.11017263,-0.06527322,-0.055322085,0.026881866,0.07423737,0.0040436722,0.0036822169,-0.045136634,-0.058373075,0.054036118,0.05010856,-0.014018399,-0.078193225,-0.041654304,-0.0050370954,-0.079542555,-0.011333961,-0.040865485,-0.0332348,-0.030822584,0.02675913,0.02908737,-0.10381891,-0.054848623,0.03725108,0.026217861,-5.921533e-33,0.12750906,-0.018655578,0.06257977,-0.034639794,-0.025187995,0.12551174,0.008862488,-0.021367759,0.016410341,-0.02766699,0.11375297,-0.021861644,0.049852107,-0.0372066,-0.00045592972,0.022694087,-0.019254142,0.035035588,-0.03279982,0.032838922,0.013583943,0.086986884,-0.021269713,-0.01670461,0.014662613,-0.004457334,0.10443614,0.06174912,0.037740774,-0.002209588,0.01094097,0.019303812,-0.0064923665,-0.077472195,0.003669848,0.060412806,-0.057691883,-0.006243817,0.02558127,0.009118604,0.0022805557,0.019810539,-0.0482267,0.115951315,0.05236167,0.040242065,-0.049195472,-0.013542826,0.03508578,0.026152533,0.042548224,0.011836007,-0.0021053238,0.010224019,0.03395464,0.03769615,-0.0005020146,-0.022941085,-0.030515749,0.011559772,-0.009726788,-0.09877945,-0.029441938,-0.035745814,-0.019060336,0.019860065,-0.032680903,0.019721033,0.016106563,-0.058691006,0.0440817,-0.005563574,-0.018245382,0.028084127,-0.07658285,-0.032093138,-0.052106038,-0.0021452527,-0.008597236,0.0027464814,0.03275277,0.02351288,0.058406956,-0.034450963,0.022084378,-0.09115838,-0.02544824,-0.016444597,-0.044433657,0.010143237,-0.012811804,0.007327255,-0.05948183,0.04349832,0.010840561,-3.4062015e-08,0.034226242,-0.032507356,0.056913525,-0.02986167,0.0034868063,0.011721142,-0.012582533,-0.05697116,-0.018458268,0.033106193,0.003185566,0.13606238,-0.029283674,0.03378237,0.036404505,0.009587661,-0.056770712,-0.021040913,-0.034299806,0.04449618,-0.006752798,-0.04722367,-0.11589004,0.057654154,0.053091682,-0.07813923,-0.043281518,-0.06776036,0.0127593195,-0.014699277,0.019163884,0.04701449,0.027743537,-0.031848382,-0.023424378,0.020380074,-0.028052587,-0.112162136,-0.061025813,0.015370977,0.09129837,0.025670541,-0.07100316,0.021431468,-0.01598258,0.0020270264,-0.0056336713,0.05302581,-0.054512814,0.015259589,0.07363047,0.028508354,0.010180762,-0.046785463,-0.11070942,0.050560836,0.013807135,-0.06919572,-0.05455283,-0.02967794,0.070465684,-0.05438657,0.14492825,-0.01099375 +1.17.5.3,"The enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups. Formate dehydrogenase-N oxidizes formate in the periplasm, transferring electrons via the menaquinone pool in the cytoplasmic membrane to a dissimilatory nitrate reductase (EC 1.7.5.1), which transfers electrons to nitrate in the cytoplasm. The system generates proton motive force under anaerobic conditions [3].",384,1.0,-0.079030104,-0.049334582,-0.12967189,-0.024951616,0.057360448,-0.0019571078,-0.05344399,-0.01216072,-0.005237102,-0.049931873,-3.5896646e-05,-0.049444508,-0.08339195,0.003019277,-0.10264592,0.013563733,-0.049940992,-0.012275921,0.014547281,-0.05325658,0.03471429,-0.023157049,0.023035292,-0.06344602,0.015146648,-0.0011367026,0.014144213,-0.0251364,-0.056199178,-0.110519476,0.032238115,-0.03308277,0.07067742,-0.026463771,0.0465149,0.15549892,-0.010812263,-0.01890297,0.032560192,0.08037806,0.029964723,0.024847984,-0.008632097,-0.0041968105,0.026393661,0.022848645,-0.0039581764,0.0445724,0.0016114349,0.013817776,-0.005249734,-0.07143327,0.0045175934,-0.019739067,0.018343395,-0.013565386,-0.018769143,0.028127199,-0.00968114,0.016037725,0.061735675,0.020852193,0.043483626,-0.0049924934,0.067511395,-0.034324523,0.109502375,-0.04404005,0.007001001,-0.11128411,-0.02545144,0.013361191,-0.04301033,-0.07319699,-0.09411766,0.044751886,-0.008950357,-0.010880327,0.049027026,-0.042651925,0.01446259,0.06144398,0.010533006,0.091854505,0.050683487,0.009064243,-0.022061478,-0.023762234,0.0006433831,0.029273087,-0.005788852,0.037371,-0.039211944,-0.0056688967,-0.10358959,0.05009206,0.012465941,0.05188306,-0.011236687,-0.023146534,0.014653443,0.12629662,-0.0232033,-0.03621327,-0.07153239,-0.0004141389,0.016628299,0.078260146,0.018758057,0.08475735,0.008842677,0.056268357,0.024727656,0.0074561555,0.03647862,0.030186199,-0.027358804,-0.008569708,-0.023823941,0.044818744,-0.008618966,-0.014209617,-0.057223104,0.050736833,-0.01478638,0.012823459,-0.084146746,7.1075854e-33,0.07315467,-0.008708282,0.032327347,-0.010878913,0.019822102,-0.008590163,-0.07301169,0.017089305,-0.034927994,0.0018438094,-0.040209774,-0.06304918,0.10676755,-0.05062118,-0.017556796,-0.046104264,-0.00408109,-0.037664883,0.011406968,0.04723641,0.027829643,0.058179405,-0.06504368,-0.034159023,0.055622652,0.05656031,-0.036458775,-0.023612449,0.0651421,-0.013237061,-0.033108175,-0.1252473,-0.0767785,-0.037776098,0.04286295,-0.052459996,-0.06874434,-0.015452451,-0.0053061927,0.07464623,-0.07559046,0.05348366,-0.0131378565,-0.044951357,0.086322114,0.015718065,-0.007844892,0.0725367,0.03708877,0.03401036,0.021278415,-0.056980316,0.1004717,-0.07291007,-0.02781498,0.008204897,-0.04213506,0.0168264,0.027283382,0.06933655,0.0688651,0.031187376,-0.0398416,-0.023503728,0.05166512,-0.028323084,-0.04634565,-0.056427196,0.06565528,0.06687241,-0.09287825,-0.017356424,0.05865571,-0.0021120978,-0.043418877,-0.016620968,-0.038349647,-0.024323849,0.056326758,-0.036851212,0.022796884,-0.0067648934,0.025080357,-0.087656625,0.007462341,0.024805315,-0.0041198637,-0.05227338,0.014010388,0.017480893,0.07781077,-0.10701173,-0.05263956,-0.07467863,0.055622548,-6.654487e-33,0.12888065,-0.014879728,-0.013324753,-0.10181614,-0.051310435,0.099210456,-0.002886465,-0.0073482413,0.035088103,0.034525875,0.03138414,-0.01634233,-0.0028066898,-0.060245287,0.053438433,0.0016650339,-0.057668474,0.11205336,-0.0057859295,0.009340918,0.017486556,0.09725118,0.039632898,0.043473717,0.102567635,0.012949744,-0.032343596,0.03461876,0.061253335,0.042437673,-0.05027487,-0.03895526,-0.059222065,-0.015050306,0.012281319,0.019299647,-0.09234893,0.05950595,0.028165273,-0.0059251566,-0.034023672,0.07878188,0.061756745,0.11012632,-0.00027523088,0.07218313,-0.13268948,0.015732192,0.009067157,-0.0156493,0.013102799,-0.027739221,-0.08380132,0.018330652,0.03070372,0.027588107,0.03452463,0.013690997,-0.015589704,-0.015500936,-0.04432682,-0.10980706,0.037656233,-0.012282947,0.0048955143,0.021352604,-0.015928455,0.073820144,0.07185849,-0.016084503,-0.011838036,0.015652163,0.056719862,0.043008313,-0.06433225,-0.02120564,-0.024534272,-0.0043192836,-0.00494657,-0.04607056,-0.012183514,0.04481518,-0.053066958,-0.09225495,0.058579355,-0.06372183,0.08883381,0.09888396,-0.006969613,0.029532783,0.017688302,-0.03471095,0.017857278,0.03527933,-0.010344802,-4.8318967e-08,0.058907606,-0.057413906,0.092277616,-0.03616617,0.034078125,0.04264402,0.0036800585,-0.022194013,0.022136852,0.0014712707,0.07027235,0.07312632,0.0069675394,-0.036282357,0.06579488,0.08432052,-0.018230924,0.004621184,-0.03574437,-0.014360187,-0.03663378,-0.027081888,-0.20939068,0.10092743,0.030067122,-0.011045799,0.05502872,0.004568028,0.017603232,-0.015545914,0.0056171673,-0.0031508238,0.067838214,-0.056548323,-0.04761483,0.008383737,-0.013087336,0.00012433104,-0.036339987,-0.025035478,-0.040563975,-0.060172275,-0.022049556,-0.004996434,-0.030548653,-0.00090513955,-0.040250722,0.033367887,-0.039951824,0.08670231,0.023655038,-0.07773858,-0.0017475608,-0.014994801,-0.102414995,0.027027296,-0.043123282,-0.092525385,-0.0006960913,-0.048115227,0.040137835,-0.010168018,0.17132854,-0.0240578 +1.17.98.3,"The enzyme, characterized from methanogenic archaea, is involved in formate-dependent H2 production. It contains noncovalently bound FAD [1]. ",384,1.0,-0.06241242,-0.037712738,-0.07609685,-0.02864505,0.09870753,-0.022183388,-0.113118835,0.042578313,0.0175319,-0.016656408,-0.05141438,-0.037901305,-0.0728837,0.00823585,-0.06438252,-0.013381779,-0.076653466,-0.03607335,-0.0004365266,-0.008015161,0.091609344,0.09821413,-0.016945178,0.008154961,0.0030046634,-0.01319236,0.064694904,-0.04704282,-0.0012680809,-0.050627157,0.032778352,-0.04979137,0.09453672,-0.015875267,0.08022854,0.08422871,0.06355485,-0.05935249,0.023725925,-0.050804045,0.077724054,0.013811523,0.055685785,-0.008592476,0.005769223,0.018790161,0.07560585,-0.0039099227,-0.037079755,-0.05343425,-0.02000914,-0.07708832,-0.074829176,-0.01092763,0.035290077,0.10834227,-0.0074744974,-0.049545385,0.012705941,-0.0068958225,-0.008944964,0.01351375,0.033186376,-0.029370332,0.055458084,-0.03959893,0.044108074,-0.05102967,0.043731235,-0.021097388,-0.041938983,-0.0080373855,-0.039374363,-0.06876921,0.0023799345,0.021898467,-0.02606777,-0.07533863,0.07640838,-0.05117453,0.017335841,-0.020247435,0.09610939,0.060077813,0.017132843,-0.050024252,0.048356604,-0.021608764,0.034794103,-0.029461006,-0.03295423,-0.01810243,0.01536855,-0.048729535,-0.09893573,0.050087377,0.10402701,0.045982584,0.022804815,-0.012913135,-0.011150312,0.039063293,-0.03174233,-0.06463906,-0.0584036,-0.10038574,0.020220725,0.16225782,0.01659283,0.06335144,0.07375057,-0.006258507,0.043491624,-0.0072769555,0.007098334,0.026913239,-0.00599919,-0.089277506,-0.042469718,-0.01804201,-0.028545579,0.024142057,0.07693156,0.0345027,-0.006462602,-0.012446633,-0.068326466,-2.0600674e-34,0.08149831,-0.05055725,-0.03536879,-0.017060118,-0.01887277,-0.020993577,-0.16607562,-0.03028074,0.013045062,0.006261952,-0.031600635,-0.049911663,0.036394533,-0.028154192,-0.02093061,-0.00739793,-0.0017403589,-0.008860131,0.020317696,0.045769554,-0.053873613,0.059672464,-0.0026170802,0.01564411,0.052054066,-0.04054449,0.0009740636,0.0059207818,0.08530925,-0.0040484164,0.00067036354,-0.10093622,-0.08197283,0.00090097537,0.028137945,0.050024748,-0.11700496,-0.021294137,-0.08109676,0.040412378,0.05039408,0.06939303,0.05648339,-0.05892701,0.07312321,-0.013553839,0.009242345,0.100043215,-0.0047369604,0.053106945,-0.03669661,0.01142718,0.0886733,0.0007459126,-0.06116012,-0.04102966,-0.006321668,-0.016209783,0.08620155,0.036485855,-0.028495554,0.056057528,0.0039803977,0.13536309,-0.0642046,0.028600736,-0.0021908975,-0.029198686,0.059345227,0.14603072,-0.0025274132,-0.020450553,0.055062994,0.031570014,0.027195603,-0.10896835,0.019141525,-0.079930164,0.0756072,0.012039099,0.017117564,-0.06978331,0.03447974,-0.04770079,-0.06338011,-0.02511625,-0.08407837,0.0003266193,-0.010930577,0.0801258,0.022011379,-0.075283386,-0.012038255,0.016681643,0.023490183,-4.3322358e-34,0.036098033,-0.071270294,0.047497258,-0.0924459,-0.05451563,0.094041355,-0.025921095,-0.002092597,0.052364226,-0.066449784,0.109040655,-0.0035002176,0.0013238251,-0.041539144,0.02391498,-0.022963597,-0.050583687,0.044429146,0.06682202,0.0533145,0.05430538,0.0099002365,0.008340661,0.020109726,0.0609682,0.00088051107,-0.013687712,0.07760638,0.012340596,0.03726246,0.0041114865,0.0075245025,-0.046523824,-0.031595647,-0.14342947,-0.039055284,-0.0019769398,-0.0027856822,-0.032638438,-0.031602137,0.03947728,0.059886415,0.0015161942,0.102320574,0.020252526,0.055984013,-0.0731987,0.043004774,0.055796612,-0.051997904,-0.030763052,-0.07656047,-0.010676712,-0.058443837,-0.008815654,0.04186879,-0.016818551,0.07414975,-0.04512589,0.011215738,-0.009475806,-0.07929673,0.06447547,-0.017112533,0.06776279,-0.014942624,-0.0018985809,0.068176486,-0.005155108,0.05528665,0.08177991,0.02870555,0.018530205,0.069082715,0.022597086,-0.052816868,-0.039077967,-0.004510398,0.07371382,-0.010291105,0.025392497,0.06564483,0.0049965694,0.000321449,-0.009562657,-0.06799704,0.07009146,0.060175087,-0.059934847,0.031984735,-0.02725127,0.03367392,-0.027156234,0.0054246965,0.007580246,-2.6488081e-08,0.05257398,-0.08377498,0.07851776,-0.041512463,-0.011970286,0.08628067,0.021707566,-0.0020978213,0.059018802,0.022898637,-0.040231206,0.07961205,-0.008254732,-0.03984194,-0.01340212,0.05999725,-0.054656964,0.0052644736,-0.095546626,-0.023943895,-0.035531905,0.010494316,-0.045615494,0.015031472,-0.014554236,-0.035194907,0.030618554,0.053293016,-0.06890644,-0.062494136,0.010926978,0.0080286395,0.033217717,-0.022893399,-0.08792413,0.018858992,0.00051709026,-0.014360737,-0.04263207,0.033580065,-0.013847256,0.028434446,-0.03666604,-0.005848348,0.016585067,-0.0095972195,-0.030219316,0.027751906,-0.06393743,-0.0074569527,0.043151096,-0.001956882,0.04753762,-0.08605369,-0.081454344,-0.027850311,-0.0060193944,-0.049748193,-0.04048093,-0.010361159,0.12539461,-0.03480523,0.09970609,-0.01363612 +1.17.99.7,"Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1].",384,0.9999999,-0.0324189,0.030093208,-0.073330924,-0.0037589534,0.047629442,0.0020049263,-0.09526018,0.03636477,-0.0020034262,-0.055857748,-0.01593713,-0.02526544,-0.074647315,-0.0014937214,-0.045289487,0.0038743943,-0.10928017,0.002930987,-0.02067973,-0.11005467,0.061898023,0.05611054,-0.03345333,0.012672094,0.031331476,-0.016694754,0.05475579,0.021565445,-0.05124518,-0.08213115,0.009699314,-0.075323395,0.099905066,-0.019667806,0.03409989,0.083487384,0.04786518,-0.072483785,0.04176183,0.023023972,0.046026655,-0.0015446353,-0.03731371,-0.067791305,-0.06130718,-0.018256005,0.040022727,0.012800105,-0.022113943,-0.0014235395,-0.010831104,-0.06166789,-0.0818448,0.018705899,0.009267822,0.052582357,0.036286656,0.03046361,0.0014998568,0.022611957,-0.033005532,0.017719751,0.015830623,0.014741608,0.012132317,-0.031843293,0.09579946,-0.048811562,-0.026554165,-0.119518556,-0.052657943,-0.033479173,-0.07294862,-0.0046301004,-0.09585205,0.019327601,-0.042020753,-0.038613606,0.053214602,0.042365164,0.06130187,0.02000527,0.097750925,0.076334596,0.05605361,-0.015961774,-0.007153113,-0.040548142,0.018313373,-0.040529158,-0.016857497,0.0020020076,-0.07407592,0.011661007,-0.03486884,0.084218025,0.13128829,0.0853003,0.04907784,-0.0021411218,0.0013525202,0.05517141,-0.03480096,-0.06812571,-0.035497714,-0.024177842,0.039455604,0.11855375,-0.033449877,-0.004491099,0.048632413,-0.03429245,0.022098152,0.015436754,-0.012024449,0.062600784,0.017145326,-0.006321479,-0.046769477,0.012381677,0.04225978,0.016038574,0.015701093,0.006380221,0.0083185155,-0.00011447294,-0.06601399,2.92945e-33,0.03828865,0.009599566,0.0004951805,-0.007800925,-0.029794628,0.01021583,-0.120150685,0.055893254,-0.0029453556,0.013000811,-0.04795117,-0.01746015,0.06942759,-0.04988859,-0.029954642,-0.028239833,0.014601874,0.04118356,-0.025960578,0.065898806,0.017593248,0.06492746,-0.014582085,-0.0029129556,0.020717641,0.058914505,0.019606607,-0.041323077,0.057666395,-0.007908475,-0.04538243,-0.122640446,-0.08753429,-0.05019159,0.011695846,0.00401476,-0.05919215,-0.09031473,-0.01568801,0.012818971,-0.06406962,0.03960907,0.018959308,-0.08418178,0.046997923,0.032149207,0.04571137,0.022715025,0.0073646237,0.04778874,-0.007575677,-0.026497042,0.09184795,-0.06703271,-0.05907839,0.03344936,0.0056486367,0.010445624,0.08724965,0.095083326,0.026131108,0.08118325,-0.040310998,0.017705167,-0.007954386,-0.057441335,-0.047140248,-0.07858567,0.03738315,0.038276415,-0.031501755,-0.018026747,0.06476137,-0.0010450374,0.020699652,-0.07407526,-0.009583053,-0.022053955,0.062063362,-0.030576047,0.010216191,-0.037813872,0.056595463,-0.06345589,0.025583953,-0.037883513,-0.06915719,0.047797646,-0.04335401,0.031854168,0.013147862,-0.0935916,0.01612805,-0.064499974,0.052573487,-3.384668e-33,0.055552345,-0.04630811,-0.0029893795,-0.0902704,-0.037108034,0.1174913,0.017838804,0.013257259,0.03849378,0.0007967623,0.054846603,-0.016053803,-0.010305258,-0.10367335,0.031797227,0.027486471,-0.0922844,0.042529088,0.0060305954,-0.017496414,0.052567396,0.058829296,0.08997657,0.036114898,0.100333154,-0.042931803,-0.007567526,0.040567826,0.08002066,0.05831791,-0.032826737,-0.07492601,0.041950766,0.0148266805,-0.029469546,0.03799605,-0.019992655,-0.03221213,0.044678204,0.02321175,-0.037387762,0.03096546,0.047035307,0.12643732,0.0045906575,0.07558686,-0.13960426,0.037122477,0.03328147,-0.0077106752,-0.03533504,-0.03868499,-0.093153864,-0.045331627,-0.043702677,0.013520902,0.008345406,0.036806602,-0.12200357,0.012945809,-0.029472573,-0.054489758,0.05800146,0.08451243,0.018448897,-0.00012247915,0.0037189457,-0.030591773,0.0075478386,-0.0020152188,0.114395365,-0.014218172,-0.0041460684,0.042097546,0.02925932,-0.09383132,-0.04150942,0.024789037,-0.007987307,-0.0044152793,0.027037399,0.015834998,-0.010309551,-0.058161613,0.052728202,-0.09732357,0.033876717,0.1121465,-0.05245213,0.007916309,0.012082432,0.023000794,-0.004397338,0.08071631,-0.0016142298,-3.7981984e-08,0.028513342,-0.09605795,0.11134442,-0.06805894,-0.01765574,0.011278394,0.06585553,-0.014889731,0.04608153,0.019615792,0.0465458,0.026995087,-0.0279166,-0.03557969,0.04161246,0.06304992,-0.019707734,0.033997633,-0.053213935,0.043141082,-0.005054146,-0.019017246,-0.11644215,0.080752805,0.021339284,-0.0077707646,0.035900827,0.073245294,0.03407739,-0.03464141,0.0071868594,0.044047926,0.040135115,0.0065168287,-0.1123589,-0.04224493,-0.00204425,0.04535171,-0.058937024,0.037789535,-0.034211915,-0.032204065,-0.030330746,-0.02394345,0.008851294,-0.0008116224,-0.0008824755,0.044856012,-0.0056028934,0.05168814,0.04654927,-0.020408379,-0.0238415,-0.03720157,-0.09130303,0.013633071,-0.03606423,-0.06537177,0.02274186,-0.051807445,0.08864154,0.012588139,0.20039473,-0.02886602 +2.1.1.343,"The enzyme, characterized from the soil bacterium Streptomyces davawensis, catalyses the last two steps in the biosynthesis of the antibiotic roseoflavin.",384,1.0,-0.096187405,-0.018783892,-0.16044882,0.007885552,0.041088965,0.069052026,-0.109059855,0.05560514,0.027769567,-0.054108202,-0.0768858,-0.008934897,-0.061203606,0.0034317384,-0.05903473,0.015979512,-0.11662602,0.045483153,0.010043071,-0.06552288,0.056721814,0.06401281,0.019086694,-0.050514083,0.07629531,0.005850285,-0.041027546,-0.006265145,0.0039051843,-0.04792176,0.07660151,0.010470725,0.07957179,-0.072388984,0.026363134,0.13030615,-0.0044111456,-0.11841673,0.0653267,-0.012257172,-0.012975139,-0.016024146,0.024135083,0.06068047,-0.00806168,-0.016376125,0.03372394,0.070395395,0.046434347,-0.027255747,-0.06008076,-0.02698742,-0.058927108,0.040811718,0.085552976,-0.0060150553,0.03876625,0.013214226,0.01704923,-0.044027127,0.07860306,-0.04347119,0.0066131754,0.026198544,-0.0899276,-0.053729452,0.06145687,-0.07885201,0.0314037,-0.02682632,-0.024669044,-0.014565178,-0.0013748677,0.023776367,-0.031177562,0.02348522,-0.01764888,0.044348683,0.0060399147,-0.038594477,0.10162987,0.04806464,-0.008649206,0.13974258,0.020994447,-0.026543055,-0.014780939,-0.041197203,0.07194282,0.03317708,0.025649771,-0.037480008,-0.029177774,-0.050027847,-0.06873688,0.011632303,-0.0014845,-0.039567135,0.025942728,0.03342261,-0.038844645,0.032173768,-0.008457657,-0.051310327,-0.03824327,-0.017696613,-0.0669045,0.06713292,-0.0124365,0.023737203,0.05766689,-0.01675102,0.019599257,0.01672813,-0.04718557,0.0025379846,0.087311044,-0.04353796,-0.11286141,0.024767678,0.009574055,0.009730357,0.06507685,0.021518728,-0.024032326,-0.097061664,-0.046216834,1.2046502e-33,0.01979567,0.008164773,-0.04011347,-0.05429568,0.037204064,-0.07964845,-0.07830452,0.0823248,0.031649996,0.02131765,-0.070581615,-0.07495903,0.008835842,0.026500683,-0.032407314,-0.06985937,0.07417732,-0.01689132,0.03655921,-0.006471104,0.033510208,0.04600908,-0.048530605,0.052595884,0.059796955,0.06460205,0.04741112,0.044946108,0.042237695,-0.018027436,0.021426594,-0.14635557,-0.0783918,0.04948074,0.03206011,-0.02115869,-0.08055403,-0.04649094,0.06511148,0.05277434,0.029229214,-0.0400247,-0.00072704005,-0.017719159,0.10362679,0.0040284996,-0.04471609,0.024869254,0.061677236,0.064526014,0.026968502,-0.035860457,0.11081828,0.050294116,-0.07765508,0.016668988,-0.018435825,0.0467041,0.06292769,0.042439,-0.03091612,-0.008045809,-0.015796464,0.01252698,0.0010892196,-0.06349338,-0.015728036,0.0008202986,0.025696589,0.048231583,-0.009560085,-0.014097104,-0.019405177,0.041301373,-0.010960344,0.014278634,-0.021850334,0.056893773,0.13562918,-0.042302225,-0.01983681,0.038022507,-0.04081712,-0.018538807,-0.06402094,0.04767686,-0.06139184,-0.034346808,-0.0668725,0.05562177,-0.010167059,-0.066970915,-0.0063064606,-0.015655786,0.04878835,-2.095034e-33,0.103164844,-0.05646137,0.033742107,-0.03533507,-0.059782777,0.063229084,-0.040696073,0.02112545,-0.043505948,0.0062332004,0.014120223,-0.020684779,0.009710771,0.01854026,-0.023939803,0.044964556,0.051101536,0.030005522,-0.06534932,0.015920576,-0.04669282,0.048055883,-0.013285108,-0.002563352,0.0028009745,0.038902733,0.06825127,0.030605113,-0.006575442,0.13056083,0.015780324,-0.07776787,-0.08747618,-0.05637772,-0.05443503,0.116698265,0.03585979,0.018497333,-0.011669087,0.023509653,0.040238563,0.010464237,-0.009146251,0.029690325,0.054946,0.038734004,-0.09244319,0.06866267,0.047479,-0.09946948,0.0591147,0.09623231,0.0028680735,-0.0040898714,-0.04011694,-0.034203216,0.030595804,-0.09498174,0.03687692,-0.03330783,-0.01296564,-0.07708159,0.021815948,0.03881119,0.030829826,0.068021774,-0.035755202,0.05512172,0.019059902,-0.03491894,0.019421985,0.00128597,0.029169746,0.038988054,-0.043413617,-0.01658385,0.011501029,-0.045961123,0.017544998,-0.042846538,0.004026154,-0.07548104,-0.010510365,-0.006495299,-0.055999648,-0.049816504,0.05471405,0.01840113,0.014404639,0.037797194,-0.0557031,0.07074007,-0.041258086,0.04028327,0.07603676,-2.705005e-08,0.016763633,-0.038744777,0.074973464,-0.033767927,0.043163534,0.019830158,0.0068651126,-0.004500978,0.022142505,-0.056970514,-0.06754217,0.07966313,-0.00033129423,-0.01860952,0.038485795,0.006088635,-0.056769516,-0.030364273,-0.025300004,0.008769217,0.04966388,0.014226746,-0.12272409,0.0041243234,0.038403783,-0.07988971,-0.025689652,-0.03709382,-0.0075829825,0.019317068,0.02493578,0.085987665,-0.061492063,0.012080382,-0.057579678,-0.021610355,0.061866533,-0.10043178,0.048497126,-0.037668563,-0.04125908,0.038749956,-0.050654612,0.014931057,-0.09521359,-0.02105032,-0.009516765,0.03631528,-0.021737047,-0.05416158,0.073862955,0.015572125,-0.042718697,0.01983246,-0.09720688,-0.0239198,0.0074703973,-0.007642765,-0.053938285,0.03335045,-0.023641234,-0.035626713,0.17711462,-0.03802142 +2.1.1.344,"The enzyme, characterized from the bacterium Singulisphaera acidiphila, catalyses three successive methylations of the terminal delta-nitrogen in ornithine lipids.",384,0.99999994,-0.08387649,0.0060250587,-0.06779426,-0.06322074,0.0032794317,0.037257653,-0.055633686,-0.03214275,0.04208778,-0.035117846,0.05748097,-0.09647002,-0.060812656,-0.03292324,-0.006782817,0.047409736,-0.090014994,-0.00086112344,-0.026209708,-0.048761528,0.13398047,0.07466322,0.010521052,-0.014977086,0.008797986,0.08569437,0.029407643,-0.03730305,0.03290583,-0.093180545,-0.016381169,-0.017611781,0.017447436,-0.05669577,0.07187307,0.017333375,0.0012471637,0.023868144,0.025303934,-0.0005483575,0.05328781,-0.0155645935,-0.045585223,-0.025956238,-0.0671203,-0.02450645,0.006722784,0.027392352,0.069026306,-0.0409556,-0.02955531,-0.08721614,0.033607215,-0.0011490863,-0.015087466,0.004543391,0.013263654,-0.07330487,-0.03483795,0.052034404,0.055403348,0.0068951747,0.015791759,-0.0034847644,0.028738664,-0.03994986,0.04422357,-0.13018991,0.007652891,0.010549185,-0.045751777,-0.0181368,-0.052109208,0.02047106,0.024896886,-0.014135019,0.03521749,0.009212399,0.038709074,-0.0979442,0.02431471,-0.005385138,-0.035856854,0.11184134,-0.020440994,-0.0613899,-0.039809838,0.059923682,0.09343201,-0.0067533124,-0.019709025,-0.02730111,0.010481404,-0.041376073,-0.09830268,0.07879775,-0.017150486,-0.022894979,0.077169225,0.011944854,0.008754066,0.018485693,-0.09202067,-0.08737733,-0.085588984,0.021531321,0.007315443,0.043649025,0.022359375,0.01817405,0.006258315,-0.014552408,0.07446915,0.03417049,-0.097079925,-0.013467396,-0.0023958406,-0.053302336,-0.03960682,-0.01220756,-0.047505394,-0.059258133,-0.020026967,0.06638701,-0.043516334,0.07348906,-0.15002899,2.2542172e-33,0.1193398,0.028191347,0.028405523,-0.06393953,-0.015214048,-0.020477477,-0.0034522798,-0.01769005,-0.031876188,-0.0735965,-0.021035591,-0.18346247,0.01314665,0.033131577,-0.0006063268,0.0013624823,0.028459387,0.0276469,0.021277966,0.00618854,-0.003260053,0.047824424,-0.076441884,-0.043135103,0.077659935,0.07343864,0.020236123,-0.043258637,0.053987347,-0.034822676,0.102175914,-0.11263964,-0.07119925,-0.033094194,0.13018128,-0.0041239853,0.047191236,0.049168207,-0.046688054,0.038544826,-0.014179792,0.053381264,-0.042624786,0.0072884243,0.0035041042,0.049757384,-0.06787047,0.098058425,0.07425845,0.020781133,-0.0011408832,-0.012663489,0.12569442,-0.014722544,-0.03908181,0.015590583,-0.010367265,0.0028206422,-0.02615025,-0.057285223,-0.007940311,0.02911955,-0.03444046,0.018957915,0.0225693,-0.00948362,-0.043640856,-0.024633294,0.0708279,0.025788805,-0.081831686,0.039561328,0.056648917,0.024902718,-0.014551804,-0.026628895,-0.07731902,-0.021399982,0.047395177,0.033055726,0.016105825,-0.016690673,0.059694197,-0.08939995,-0.0489277,-0.026529385,-0.04796296,-0.06911688,-0.0026658399,0.003911963,0.0012570705,-0.064495444,-0.039810322,0.014548639,-0.070725806,-3.36272e-33,0.052135974,-0.060451142,0.05414878,-0.040267903,-0.015979663,0.031746004,-0.035890482,0.08151589,-0.0047808173,-0.036119238,0.038933482,0.03374251,0.07154551,-0.029651506,0.07987364,0.055966437,0.025250036,0.114687726,0.04744758,-0.010915547,-0.04234889,0.05179369,-0.049279314,0.061888106,0.030362803,0.0344646,-0.01552558,0.10133978,0.017980866,0.03396466,0.03929631,0.00039930805,-0.0015724079,-0.0294873,0.03276123,0.0071437983,-0.010205479,-0.0065558692,0.038107675,0.043428916,-0.054262917,0.01583819,0.07387618,-0.0005411279,-0.01204894,0.011928582,-0.07117881,-0.032045394,-0.053484745,-0.07168382,0.012514443,-0.022986121,0.034063056,0.04542345,0.06028418,0.07068803,0.0073230485,0.043243594,0.034784213,-0.089530095,-0.01674653,-0.08008946,0.03922311,0.03976025,-0.042860173,0.116987236,-0.0023205772,-0.031777523,0.011772875,-0.04375196,-0.07546674,0.0013890198,0.00079707714,0.08246702,-0.04042048,-0.025721192,-0.062411793,-0.10962032,-0.014500838,-0.0042759445,-0.03016558,-0.0008603688,-0.05274134,-0.11194178,0.011396014,0.04136319,0.084238835,0.1390134,-0.035605066,0.028252723,0.009141757,-0.03322469,-0.058849204,0.10479189,0.0875538,-3.1258928e-08,0.07972802,-0.10064817,0.036763012,-0.0230847,-0.024031378,0.031840377,0.03550014,-0.032231305,0.060794663,-0.05603651,0.0374492,0.0494436,-0.010983596,0.06022139,0.02350962,-0.016390385,0.028836913,0.0012122976,-0.03461359,-0.026435118,-0.06358098,0.050958585,-0.068742126,-0.02072423,0.04004207,-0.02470254,0.019547788,0.053376492,0.026877213,-0.057189792,-0.039791353,0.070796825,0.016942991,-0.01911008,-0.026787423,0.02235017,-0.0061079543,-0.028446222,0.03327813,0.04114997,0.069660455,-0.00049409136,-0.04985348,-0.015936945,0.03375767,-0.013578154,-0.009566534,0.050107747,-0.045434684,0.014942789,-0.017574675,0.0030900456,-0.006348716,-0.03221532,-0.09864154,0.008110517,-0.047774386,0.013435823,-0.040423594,0.029638184,0.08039842,-0.015198437,0.15584102,-0.025057241 +2.3.1.265,"The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs).",384,0.99999994,-0.06498828,-0.033659916,-0.07890416,-0.020152057,-0.009220579,0.025291799,-0.011821569,0.06550717,0.05393976,0.10628256,0.052916214,-0.025898948,-0.03873262,-0.020219449,-0.024036588,0.09283048,-0.04880653,0.062335283,-0.010401464,-0.06318282,0.068066604,0.04884679,-0.026213558,0.05113401,-0.022048894,-0.02231378,0.06378874,-0.008430416,-0.009650986,-0.08080072,-0.028548662,-0.02250023,0.012437679,-0.031286124,0.08063733,0.11911484,-0.007322012,-0.14801438,0.14162457,-0.023168093,0.054614224,0.01873079,0.009531116,-0.027220242,-0.067599274,0.062363584,-0.055575248,0.047378324,0.05797536,-2.161782e-05,-0.07315433,-0.036060784,-0.048976514,-0.00689645,-0.014179985,0.08377426,-0.062348653,-0.029739136,0.027388772,0.016537324,-0.02089953,-0.026659623,0.029482562,0.08215173,-0.07949931,-0.0023122504,0.0022728562,-0.037592124,0.029765751,-0.019922763,-0.016096925,-0.05837336,-0.042073414,0.10757782,0.009483133,0.0068644457,-0.010155323,-0.040336616,-0.020284936,0.023061402,-0.008838912,0.010680169,0.0049567604,-0.029741257,0.009387697,0.016097961,0.045109976,0.0213938,0.09431794,0.057276595,0.03560736,-0.018015014,0.04957274,-0.060830176,-0.004917289,-0.014186012,0.04084482,0.014851724,0.039873738,-0.032133065,0.043703087,0.022181509,-0.040313598,-0.08338599,-0.037867688,-0.020065064,-0.0034087119,-0.051017635,0.034685906,0.09579,0.04602242,-0.00781426,0.043892037,-0.068252824,-0.037695616,0.04690897,0.087505855,-0.10696776,-0.04095916,0.019156773,-0.008906226,-0.083983265,-0.05095045,0.04725789,-0.11684129,0.022220131,-0.10910495,-2.1582935e-34,-0.015166434,-0.022514045,0.044436116,-0.00155586,0.088522404,-0.035185568,0.029839596,-0.08797101,-0.07529673,-0.11131306,-0.1609402,-0.018273452,-0.035034902,0.009762391,-0.087677054,0.069114946,-0.035100866,0.027173687,0.021029396,0.06281924,-0.045325503,0.0111141475,0.0004590989,0.02313247,0.04237355,0.108946405,-0.0578211,-0.06770527,0.08236081,-0.030087521,0.026951917,-0.053141523,-0.09521056,-0.036597803,0.017903252,-0.056841034,-0.05470298,-0.060430985,0.00930897,0.06869105,-0.029579137,0.017227925,-0.0006611943,0.021034285,-0.008943545,-0.018301845,-0.038072497,0.04117243,0.015397362,-0.0031233248,0.051657014,-0.021010956,0.05838135,-0.009346385,-0.023238027,-0.03794852,-0.04739862,-0.036355834,0.042148814,0.076765366,0.033171974,0.056340635,0.051891167,0.04667625,0.002482999,-0.01371749,-0.07569079,0.07242337,0.027841674,0.043531276,-0.0011828953,-0.07323808,-0.030509865,-0.037466183,0.066537194,-0.05254554,-0.02795368,-0.05814773,-0.09964453,0.022081967,0.101397865,-0.023022087,0.026106881,0.032125708,-0.06159605,-0.05120844,-0.025130056,-0.03461,-0.014884002,0.0030457205,0.03468406,-0.017161299,-0.063714,0.10434708,-0.07621118,-3.2177068e-33,0.07101518,-0.1044537,0.081923835,-0.0465559,-0.041346524,0.014911919,0.058973394,-0.014390937,0.0819853,0.0500071,0.04058758,-0.021906976,0.030261543,-0.007353611,-0.041549116,0.039676446,0.02167825,0.084489174,-0.022142006,-0.005542204,-0.08358196,0.117524214,0.03893613,0.010970095,0.001690603,-0.019090105,-0.08047871,0.027078934,-0.005470067,0.059119888,0.008672129,0.0014808367,-0.037472468,-0.04812054,-0.04870817,0.020986166,0.003958276,-0.0028512836,0.030839263,-0.031703588,-0.019520365,0.0058648335,0.059638195,0.023981195,-0.027247185,-0.015197764,-0.029175896,0.038479798,-0.11596748,-0.0062225265,-0.06672557,0.012277618,0.027800744,0.033843573,-0.010000914,0.023689397,-0.019292833,0.0287502,-8.8368346e-05,-0.044307604,-0.073649235,-0.12818028,0.024463546,0.024685265,0.037745114,0.12561318,-0.04444778,0.021215584,0.03519309,-0.015059077,0.024763344,0.06407818,-0.04755044,0.016234841,0.0009070734,0.041974753,-0.0718074,-0.053950075,-0.007610648,-0.011432096,-0.07581549,-0.06939845,-0.031003114,-0.0027075994,-0.016841847,-0.06806186,0.09727,0.052446462,-0.05607192,0.05548471,0.002669567,-0.010293903,-0.06383115,0.059999447,0.007246163,-2.853561e-08,0.038907778,-0.072063304,0.043653056,-0.028710043,0.019146653,0.008240543,0.010164361,0.07670022,0.011887889,0.012072397,-0.00853739,-0.0099513065,0.05692568,0.013295555,0.11095902,0.09256266,-0.08069201,0.025008108,0.012335818,-0.02191805,-0.06981148,0.018457564,-0.012351802,0.056122478,0.01421225,0.006169909,0.08579502,0.05823026,-0.078200854,0.021281857,-0.0063630096,0.016327199,-0.07406808,-0.05123517,-0.037405774,0.016211903,-0.030102072,-0.030738236,0.0043587657,-0.018330535,-0.03651499,-0.00932108,-0.015877517,0.021538386,-0.025494922,0.0746222,0.023175683,0.018190166,0.0477007,0.034253094,0.03503768,0.015243157,-0.039023664,-0.024445504,-0.057269853,-0.043362163,0.0033303956,-0.02981146,-0.0074014557,-0.02471703,0.035044387,0.04794653,0.18542066,-0.04894616 +2.3.2.30,"The enzyme, found in bacteria, catalyses the first step in the biosynthesis of ornithine lipids.",384,0.99999994,-0.13549681,0.013051161,-0.044652753,0.0040747663,0.006951605,0.04892682,-0.10165161,-0.014248566,0.033795133,0.020001302,0.014249362,-0.041109383,-0.038225766,0.013130041,-0.015262223,0.062153753,-0.09445036,0.025948977,-0.015321147,-0.01080678,0.13194132,0.056311406,0.029428495,-0.0029636656,0.03121693,0.048657876,0.058017887,-0.049825776,0.031906463,-0.060748547,0.0060085603,-0.0709397,0.040883105,-0.05378964,0.029341623,0.06798896,0.030754462,0.02268593,0.03178802,0.008519577,0.010454174,-0.0701335,-0.12003107,-0.0049455417,0.018995747,-0.058148965,-0.003827951,0.051942296,0.05431537,-0.033641912,-0.05317032,-0.01629258,-0.040030036,-0.01288405,0.017082008,0.036737636,0.02005756,-0.05767109,-0.06253838,0.016503632,0.044272218,-0.073490165,0.015616505,0.060874023,-0.0023415452,-0.051759444,0.046711694,-0.06623711,0.0092390785,-0.0048695286,-0.022988798,-0.058317285,-0.05729981,0.06818906,0.015081761,-0.0028945364,0.017935857,0.0062836283,-0.021420246,-0.041990947,0.0523841,-0.044530936,-0.025073279,0.17754902,-0.007916231,-0.010262396,0.020460287,0.022507412,0.04960519,0.036837596,-0.02340347,-0.01707533,0.002749005,-0.041749958,-0.007943632,0.057241105,0.0073330775,-0.012569588,0.11041657,-0.040743224,-0.02139012,-0.020295296,-0.058121756,-0.042281073,-0.045660447,-0.0010592361,0.009317384,0.009148037,-0.001243371,0.03516021,0.013553449,-0.017017374,0.06514243,0.034213513,-0.0783506,0.08736598,0.0146839,-0.026836123,-0.020782048,0.008598107,-0.045789145,-0.06273989,-0.03162273,0.14218818,-0.08644959,0.09715813,-0.107048035,-5.44499e-34,0.06977961,0.024466155,-0.00121617,-0.03757406,-0.043585274,0.032302156,-0.028394423,0.0128963115,-0.042096008,-0.072334655,0.009007862,-0.17128919,0.02063628,0.032515023,-0.01616692,-0.063794605,-0.012795687,0.006426772,0.009636481,-0.018033935,-0.05092415,-0.011243529,-0.054701135,-0.0047071017,0.044429716,0.049482867,0.017016618,-0.050659202,0.011580288,-0.063197754,0.04578636,-0.111743756,-0.08116778,-0.028157681,0.08117655,0.0010631769,0.042516224,-0.015208667,-0.05135156,0.02677873,-0.026182422,0.043935824,-0.026917936,-0.040980108,-0.0054616095,0.026724812,-0.115735196,0.11333864,0.094755866,0.032393653,0.0073590274,0.04707948,0.07553979,0.02361623,-0.05884226,0.021896461,-0.027908133,-0.04450775,-0.004276617,-0.018526398,0.005277875,0.06366465,-0.007709437,0.043105744,0.013118541,-0.010108954,-0.051737975,-0.0047746585,0.013491241,0.089168124,-0.030427668,0.021735705,0.02622715,0.015959427,0.038559474,0.04505211,-0.07702443,0.0013329533,0.048502244,-0.019758064,0.028441995,-0.011406397,0.014151739,-0.063506976,-0.047513094,0.0035894085,-0.059103154,-0.09198653,0.0038495278,0.0694776,0.018547619,-0.03950717,-0.053876523,0.04926396,-0.066789635,-1.01337485e-33,0.054866623,-0.11519882,0.059658017,-0.048236724,-0.03545207,0.06612646,-0.06470394,0.019027816,0.100583754,0.045921925,-0.003097161,0.009282131,0.055565637,-0.062121324,0.06804152,0.055242635,0.01839629,0.05919476,0.04982771,0.007837558,-0.008111932,0.047757667,-0.05536282,0.06463795,0.028288933,0.046037503,-0.003135632,0.07177689,0.0024899156,0.060217705,0.041157678,-0.039056405,-0.051715475,0.0059851115,0.00983291,0.09193592,-0.025418943,-0.00043414725,0.06986868,0.02480726,-0.05496357,0.04110669,0.026144743,-0.0049881707,-0.002997933,-0.033550616,-0.04664348,0.06561236,-0.05152925,-0.09498801,0.012855163,0.041439503,0.05637995,0.0075176,0.037459604,0.07198522,0.012958053,-0.023783658,0.030449193,-0.10695627,-0.014398877,-0.06177509,0.019196475,0.022039842,-0.070645005,0.114838265,-0.042982534,0.010959284,-0.0034567607,-0.06114858,-0.039540682,0.014914414,-0.021333344,0.029439112,-0.013353996,0.02092501,-0.03671816,-0.1376294,-0.013548399,-0.009661404,-0.024826935,0.04453403,-0.046370916,-0.10639089,-0.038240522,0.0077166324,0.057337977,0.08721443,-0.009206093,0.050889567,-0.03361537,-0.030550433,-0.058201116,0.08463708,0.077405244,-2.2399849e-08,0.0258958,-0.094559796,0.08003017,0.014289531,0.018863006,-0.015408411,0.062542565,-0.006048033,0.048387457,-0.072752826,-0.028072009,0.10118677,0.017648669,0.035332266,0.0850845,0.0039695557,0.029774887,0.0030361179,-0.026513064,-0.03980425,-0.029114384,0.029365392,-0.09291482,0.0028630893,0.002788003,-0.055018205,0.0419124,0.02281635,0.044297345,-0.027940243,-0.037162222,0.032696288,-0.016192414,-0.022172006,0.0038084472,0.020044127,-0.014999285,-0.0554871,0.034095693,0.0015933898,0.012809296,-0.003221428,-0.021677246,-0.008848325,-0.037124887,0.0111163985,-0.047158696,0.046507318,-0.046346944,0.010605106,0.009201869,-0.0040492066,0.005203888,-0.041086387,-0.08544569,-0.0029973614,-0.036580462,-0.034530118,-0.030480556,-0.0031227227,0.004625988,0.037749253,0.27523017,-0.008142825 +2.4.1.347,"The enzyme has been reported from the yeast Saccharomyces cerevisiae and from mycobacteria. The enzyme from Mycobacterium tuberculosis can also use UDP-alpha-D-glucose, but the activity with ADP-alpha-D-glucose, which is considered the main substrate in vivo, is higher.",384,0.99999994,-0.056145303,-0.043217123,-0.09244769,-0.04783132,0.03094064,-0.027631396,-0.0018863089,0.09592326,-0.047467526,0.06108267,-0.07523827,0.06259177,-0.04453255,0.08739649,-0.021047039,0.034634333,0.03429785,-0.007252791,0.07931705,-0.02371379,0.02312373,0.08817369,0.067701444,-0.04661574,0.10386926,-0.06160007,0.088851705,0.037764955,-0.041987963,-0.08293251,-0.024080254,-0.07829952,0.0653158,-0.061608188,0.03358963,0.104568206,-0.02092337,-0.060457632,0.07335096,-0.009293595,0.04923394,-0.053780958,-0.017757343,0.05312638,-0.014521204,0.054073207,-0.11206036,0.08372043,0.039525803,0.03733541,-0.042418946,-0.007297172,0.0026545264,0.025508042,-0.009471436,0.00917857,-0.019854719,-0.0019506072,0.008883946,-0.00057041127,-0.0314347,0.015987746,0.07409224,0.036394272,0.04351429,0.013317739,-0.017035188,-0.042036302,-0.012112497,-0.021273287,-0.071481116,-0.0431925,-0.08301551,0.07296688,-0.0127863735,-0.013339125,0.006853889,-0.057185676,0.045019113,0.019794095,-0.01013245,-0.0038024986,0.021534503,0.025976138,0.010356281,0.0016752152,0.11169276,0.025742419,0.03954845,0.024860218,0.01960463,0.018505972,-0.049439296,0.009217162,-0.08155483,-0.04317822,0.03710834,0.045540545,0.0070191864,-0.06861835,0.0033449386,0.028597983,0.0037252633,-0.043747757,-0.070490554,0.028195832,-0.046513792,0.006524292,0.059799846,0.029703889,-0.010983524,0.046650182,0.015488067,-0.013369777,-0.0032331445,0.015176763,0.052022718,-0.058941744,-0.055785593,0.009350506,0.0038549744,-0.08217284,0.03351775,0.0058401814,-0.06212479,0.101144955,-0.01631006,-9.3804334e-35,0.019902688,-0.08017052,-0.055768985,-0.029035771,0.04558984,0.019460319,-0.08592793,0.012717504,-0.06155653,-0.046652548,-0.09760968,-0.065187536,0.018970607,0.09713497,-0.07558844,0.06803459,0.07731343,-0.008509611,0.07054035,0.08415447,0.03574565,0.057156276,-0.0044640903,0.0452744,0.040933035,0.057776444,-0.0630358,0.105404995,0.044493403,-0.017344998,-0.0070085553,-0.084967986,-0.0871731,0.0035014395,0.011631735,0.023092907,-0.062133703,-0.016654607,0.032478616,0.041499253,0.05112888,-0.021996804,0.069402605,-0.027181515,0.03174123,0.06435655,-0.03389111,-0.006971306,-0.006471085,0.00413877,0.042613663,-0.015923679,-0.014067343,-0.030445555,0.042854592,0.016289504,-0.057881054,0.0639656,0.056521017,0.047477663,-0.0010918232,0.09875511,-0.0056028655,0.11425144,-0.05646875,-0.02421609,-0.03903983,-0.0011442319,-0.031007778,-0.015714614,-0.014864332,0.0059386464,0.042819466,-0.044517998,0.057136577,-0.046879105,-0.04350179,-0.054625865,0.033378106,-0.06905403,-0.0098460745,-0.05119051,-0.038688608,-0.04410059,-0.030561753,-0.0050171893,-0.07055015,-0.018924832,-0.020639006,-0.06230551,-0.023283947,-0.025547707,-0.10138931,0.06130336,0.004430962,-2.8556045e-33,0.09228944,-0.07392161,0.11026109,-0.075970836,-0.05467217,0.05041455,0.08672829,-0.0664288,0.028988164,0.0032454173,0.043062948,-0.032157518,-0.056010835,-0.0194259,0.020822085,0.03278517,-0.056808863,0.03344489,-0.08026615,-0.022335595,-0.04416034,0.12738162,0.0148722185,-0.033762928,0.058504704,-0.012959322,0.016542275,0.06819404,0.071538,-0.01865405,-1.2155839e-05,0.07172455,0.029376406,-0.04269294,-0.07070379,0.020749126,-0.03970546,-0.06586581,0.012805603,-0.0386035,0.02254364,0.124131575,-0.063463114,-0.024204211,0.014907159,0.032321736,-0.05501676,-0.015986783,-0.013380165,-0.033309046,0.0021062018,-0.008291537,0.023156483,-0.04624734,-0.02143075,0.05080161,0.019787967,0.02222225,0.01937271,-0.044138044,-0.003129369,-0.03584875,0.03449561,-0.00441397,0.046535496,0.10227874,0.046076734,0.02607654,0.04621306,-0.005783903,0.038067553,-0.014084488,-0.024899237,0.093454085,-0.0004473573,0.018914858,-0.058313813,0.050233357,0.041732855,-0.023940679,-0.03682933,0.014534213,5.9262573e-05,-0.006000582,-0.026269162,-0.08335727,-0.0019999524,0.009905756,-0.03159634,0.06911438,-0.025853854,0.025953619,-0.09653609,0.014613072,0.11293325,-3.8327975e-08,0.077318154,0.014011777,0.08607252,-0.040477578,0.047943883,-0.01846013,0.013562445,0.029710462,0.08123068,-0.008232357,-0.055322386,0.09859567,-0.029162114,-0.008622229,0.09172486,-0.023389721,-0.030470999,-0.053201277,-0.027940743,-1.9296176e-06,-0.045632817,-0.013422628,-0.07254819,0.02978523,-0.05118059,-0.060754836,0.010269064,0.021653628,0.011630897,-0.025235903,-0.0885713,0.045271967,0.011448758,-0.11690385,-0.07535792,0.012745177,-0.052975044,-0.07475379,0.009581596,0.070061326,0.040506843,-0.1262397,0.028550858,0.00071306236,-0.07717753,0.015494163,-0.032916512,-0.050639283,-0.016266238,-0.01710253,0.035624202,-0.022148594,-0.073855914,-0.043933492,-0.041353017,0.0454649,-0.10838365,-0.040483423,-0.06554203,-0.07732307,0.017471272,0.0024468636,0.15774736,-0.08620296 +2.5.1.141,"The enzyme, found in many archaea, bacteria, and eukaryotes, produces heme o, which in many cases is further modified into heme a. In organisms that produce heme a, the enzyme forms a complex with heme a synthase. In some archaeal species the enzyme transfers a geranylgeranyl group instead of a farnesyl group.",384,0.9999999,-0.07114099,0.0018211307,-0.059757944,0.010732306,0.063363425,-0.046910673,-0.036480814,0.017930122,0.085331246,0.016801413,-0.011762644,-0.066003665,-0.08883482,0.0006646229,-0.03870733,0.023117077,-0.08161837,0.024196146,-0.06727272,-0.0632078,0.047412336,0.12118224,-0.02225086,0.051755045,-0.031287935,-0.06089013,0.09852264,-0.036253806,-0.0016040242,-0.11433453,0.010417722,-0.052635822,0.11768927,-0.036465365,0.03497462,0.058930542,0.020712612,-0.089945175,0.0462156,0.011226536,0.08671853,-0.009912627,0.0055481414,-0.018409766,-0.070069574,0.037856515,0.06907648,-0.04949406,-0.015458636,0.010799026,-0.05016953,-0.059524532,-0.124393016,0.006387182,-0.0390089,0.021966562,-0.0037940156,-0.0018475257,0.011370527,-0.016987756,0.025326537,0.030726869,0.053177208,-0.015607346,-0.008486598,-0.040275536,0.091011636,-0.039822817,-0.057104975,-0.112274945,-0.016820852,-0.04083081,-0.05945906,0.07054016,-0.03708142,0.042591434,0.00205821,-0.0014092219,0.062843665,0.020848788,0.011053394,-0.004412596,0.002773905,0.070334464,0.0015152205,0.03601763,0.018327339,0.017852394,0.050169576,-0.037542827,-0.02364196,0.010991632,-0.016974289,-0.13303137,0.009482515,0.04177091,0.065520346,0.08026399,0.08690224,-0.011581101,-0.0075287074,0.030718386,-0.009241709,-0.035891287,-0.060628958,-0.0016335931,0.0014337458,0.085111834,0.08305572,0.03650739,0.03714638,0.008879066,0.09851501,-0.030464536,-0.017484961,0.019863676,0.01841387,-0.036094252,-0.092481546,0.074880354,-0.03940163,-0.014008413,0.08742663,0.06350763,-0.017154058,0.054613646,-0.109335504,7.461145e-34,0.018808391,0.015768662,0.020849735,-0.015038667,-0.030554134,-0.012010066,-0.090491764,0.04138509,-0.007879347,-0.036874842,-0.09619534,-0.073104054,0.018981114,0.016446654,0.022745995,0.022857416,0.02165292,-0.033036206,-0.036380857,0.042483736,-0.011826875,0.044639748,-0.008958918,0.017007012,0.002303841,0.045187015,0.048182026,-0.06956133,0.029656423,-0.017450003,0.012776448,-0.1115828,-0.07348849,-0.035173316,0.050196055,0.00604486,-0.032951467,0.013699684,-0.04934564,0.029513258,-0.01930812,0.06951573,-0.007683333,-0.020989075,0.11148638,-0.052535754,-0.03618075,0.044657636,0.03870377,0.036636367,-0.06770937,-0.032674216,0.09769617,-0.015580662,-0.032745596,-0.030502329,-0.039402403,0.026198866,0.12801285,0.069309145,0.068497926,0.10003958,-0.053855356,0.07417661,0.00040544991,0.047744676,-0.023021758,-0.0069322214,0.030400567,0.044757187,0.014619118,-0.046519253,-0.032151345,0.01873848,-0.022766503,-0.07749629,-0.08826389,-0.036544234,0.052179933,-0.05237268,0.018356815,-0.049840454,0.047034103,-0.026002662,-0.018430332,-0.025287265,-0.05171316,0.025578368,-0.060750514,0.05101183,0.06024665,-0.09880295,-0.0312525,-0.066156834,0.04398266,-1.9034055e-33,0.09841243,-0.06368709,-0.033277325,-0.118849225,-0.031750116,0.070334494,-0.0426447,-0.03327748,-0.044758607,0.00032181098,0.06713211,0.008782629,0.014571616,-0.087847054,0.017393766,-0.07356136,0.057595216,0.012359775,0.03719663,-0.0041779387,0.013869608,-0.007951326,0.042788416,-0.021633765,0.06860757,0.0066214674,-0.07350261,0.10180232,0.033648405,0.03691844,-0.024517294,0.013898447,-0.0026857723,-0.0004940054,-0.054011874,0.020600613,0.02164754,0.01869743,0.041958585,-0.0050893677,-0.005780801,-0.017419703,0.06855889,0.12050661,0.02527672,0.08734876,-0.11312917,0.025994098,0.025570614,-0.01842335,0.04028846,-0.0052241897,-0.009010799,-0.07634863,-0.012519701,-0.0065651475,0.004440448,0.014366937,-0.09016235,-0.04845782,-0.06198868,-0.06094036,0.06880749,0.030588232,-0.011854541,0.0829514,-0.053444624,0.0637128,-0.0084341625,-0.0469384,0.029851709,0.017800942,-0.0055137933,0.0076282504,0.026853822,-0.025458142,0.023154149,-0.018722158,0.051987056,-0.05339733,-0.055568215,-0.0075061778,0.020678464,-0.08422791,0.021339063,-0.066676036,0.0133623695,0.05250959,-0.018730741,0.02501055,-0.03588775,0.0043557496,-0.06012573,0.010657154,0.04315852,-3.4953867e-08,-0.01472748,-0.076687165,0.058275938,-0.009383468,0.015841546,0.027820053,0.01488803,0.058074445,0.05405626,0.019285552,-0.048856504,0.07885481,0.030869981,-0.0048845746,0.10220471,0.06392927,-0.01905588,-0.0052910205,-0.03173321,-0.0386547,0.0004878596,0.009501439,-0.061580338,0.091120206,-0.008717411,-0.09968775,-0.04140425,-0.051834807,-0.022754814,0.0011984551,0.02496744,0.039467882,0.008393146,0.020124838,-0.012583119,-0.06855854,-0.009923652,-0.025468638,-0.016637824,-0.025468033,-0.00041979973,0.008186047,-0.12082462,-0.032353397,0.05844744,0.039534133,0.031391326,-0.027004374,-0.034655187,-0.015538733,0.07849219,-0.012962009,0.035051297,-0.012605873,-0.0904515,-0.068936974,0.040146254,-0.0882743,0.003384212,-0.028082177,0.084666945,-0.013569993,0.20486715,-0.011021993 +2.7.1.218,"The enzyme, characterized from the bacterium Escherichia coli, has very little activity with fructose.",384,0.99999994,0.06782105,-0.05074486,-0.10840319,0.047023576,0.04922961,0.0011945356,-0.11613431,0.08309145,0.053206943,-0.019388169,-0.004623187,-0.058890715,-0.025613151,0.047141414,-0.011015169,-0.030613093,-0.0055563664,-0.052041482,-0.0493623,-0.052185245,0.052198227,-0.047104467,0.035097715,-0.016985603,0.037202515,0.013300635,0.029388256,-0.054831542,-0.024676425,-0.066740274,-0.037434213,-0.012367849,0.0566999,-0.026676891,0.11467864,0.10070461,0.06762669,-0.02499666,0.043786507,-0.03386291,-0.0793368,0.025745438,0.019275486,0.01332553,0.01761786,-0.01743624,0.008739417,-0.043874998,-0.03580737,-0.03979133,-0.028998733,-0.0495744,-0.022866186,0.021963531,0.022284536,0.048109096,-0.015676007,-0.06441576,-0.021275368,0.06166603,0.00691216,-0.021608366,0.06387062,0.023632355,-0.006665881,-0.057003427,-0.022437077,-0.059699357,-0.030359605,-0.01596622,-0.05044676,0.002244651,-0.028488994,0.08515896,0.023963625,-0.092463456,-0.025114318,0.008951862,0.051282767,0.13622253,-0.0184331,-0.053860568,-0.037526473,0.032143034,0.0042808875,-0.03387522,0.057918895,-0.025630785,0.007899083,0.028311728,-0.040067956,0.03365554,-0.014355405,-0.08588676,-0.022138797,0.026838584,-0.029196838,-0.00546378,-0.031015607,-0.023839489,-0.018862475,0.037257787,0.07216293,0.0032335278,-0.076845974,0.036198474,0.005225902,0.11484874,-0.048472054,-0.0100962445,0.018777769,-0.043690015,0.0734939,0.02874749,-0.092810936,-0.0018097616,0.0038167322,-0.14189392,-0.07346266,0.08970021,0.01325026,0.038730297,0.07997858,0.10622365,-0.06642886,0.0515025,-0.050746597,-1.0193478e-33,0.108329386,0.013587575,0.01729111,-0.0821729,0.042352017,-0.0019914312,-0.0045886897,0.040411346,0.028949626,0.035234842,-0.029473845,-0.018150378,0.08950348,-0.02633818,0.04128529,0.018661063,0.02169771,-0.06854083,0.05143153,0.007427207,0.026078822,0.038737487,0.023670832,0.007881502,-0.011407868,0.017309222,-0.006305477,0.030394906,0.0064240615,-0.00016968237,0.01383168,-0.0396244,-0.04862251,-0.016759373,0.1273813,0.017738732,-0.026484892,0.00659992,-0.07132064,0.03211305,-0.011832478,0.06486527,0.00051122415,-0.08668576,0.042033706,-0.03416427,0.024276953,0.084931746,0.0023348439,0.058279857,0.056463547,0.0062350873,0.01050045,0.026259264,-0.01468954,0.043093957,0.01402936,0.002283715,-0.052391116,0.001792249,-0.047739323,0.06060521,-0.058021937,0.018456254,-0.029725771,0.035639804,-0.041440357,-0.0012270482,-0.026885448,0.106995605,-0.022672161,0.00948998,-0.0050989427,-0.041402757,0.097596586,-0.04947356,-0.039713003,-0.041033633,0.011278549,-0.02277812,0.044438567,-0.04293824,0.025422934,-0.053145405,-0.07979161,-0.045499563,-0.08902233,0.021580888,-0.021397814,0.058678813,0.02625334,-0.055296812,-0.037025057,0.044111695,0.06224654,-1.616748e-33,0.07903407,-0.089010864,0.0654952,-0.045870073,-0.044419426,0.085363194,0.01340067,-0.015179853,0.09120046,-0.03408791,0.10256033,-0.002794538,-0.02272866,-0.05636483,0.034326743,0.08516577,-0.037574854,0.065106556,0.015941344,0.06314683,-0.024801046,0.08020976,-0.059652116,0.009009106,0.04865597,0.051313717,-0.020452753,0.053436678,0.04944441,-0.027582966,-0.009560028,-0.035137102,-0.007124906,-0.13699155,-0.0968344,0.021632949,-0.052480035,-0.0038403955,0.029459042,-0.023782121,0.025907911,0.09372282,-0.002204886,0.00036077405,-0.033309918,0.052028652,-0.0987223,-0.02013738,0.015015465,-0.015433573,-0.010434473,-0.050535645,-0.030682564,-0.026997281,0.0313394,0.051175777,0.01107076,0.014406684,-0.015040064,-0.019293435,-0.00035853358,-0.08479525,-0.030806486,-0.007872568,0.04960628,0.0012448567,-0.037674006,0.08067618,0.051157992,0.0047285575,0.06962605,0.0077769314,-0.0029468697,0.016617063,-0.0018699823,0.016887253,-0.08606988,-0.044939265,-0.004142705,-0.018863395,0.055932455,0.05696428,-0.055039413,-0.13233249,0.07244142,-0.056502968,-0.039033227,-0.009718026,0.0020486806,0.0806383,-0.07374918,0.026175354,0.076707006,-0.01800493,0.04604751,-2.220908e-08,0.022768423,-0.045942776,0.015198325,-0.025444742,0.03315093,0.04453942,0.004124801,-0.012858548,0.005632744,0.0075738584,-0.03768856,0.12528898,-0.063134484,-0.012608643,0.0072135744,0.018132996,-0.04303757,-0.071832836,0.024395915,0.0033494057,-0.10258142,0.00602242,-0.110654205,0.03674523,-0.00030703266,-0.05887639,0.05081311,0.010759193,-0.050262704,-0.028909521,-0.025660768,0.038515292,0.06101174,-0.010925147,-0.14538002,0.0021068736,0.028745579,-0.025617877,-0.14021043,0.0032506976,0.03400154,0.053806514,-0.07141235,-0.043602545,-0.07435171,-0.029514097,0.030235007,-0.018422998,-0.0196511,-0.031213906,0.055709504,0.016368791,-0.10052451,0.04839615,-0.04797806,0.029796517,0.068772845,-0.08307169,-0.080650784,-0.039637156,0.08537475,-0.018386623,0.17053697,-0.02325367 +2.7.1.219,"The enzyme, characterized from bacteria, is involved in a pathway for D-threonate 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+2.7.1.220,"The enzyme, characterized from bacteria, is involved in a pathway for D-erythronate 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+2.7.1.221,"The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage 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+2.7.7.99,"The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage 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+2.8.2.38,"The enzyme catalyses the last step in the biosynthesis of aliphatic glucosinolate core structures. cf. EC 2.8.2.24, aromatic desulfoglucosinolate sulfotransferase.",384,1.0,-0.06262101,-0.022647858,-0.10741075,-0.03450757,-0.017567465,0.026027158,-0.079234146,0.054949947,0.05913377,-0.050472733,0.04389925,-0.0254748,-0.06315132,-0.05963096,-0.05955632,-0.0009377343,-0.09588436,0.019397136,-0.071387365,-0.0906856,0.10687775,-0.004158606,-0.053546913,-0.002156745,0.034963883,0.048345856,-0.0053734467,-0.043067608,-0.014948649,-0.102491185,0.02295708,-0.062242925,0.047772367,-0.042548914,0.08096276,0.058344502,-0.038914256,-0.034044053,0.109301634,-0.07014308,0.024548346,-0.01217391,-0.031433854,-0.012528154,-0.008514982,-0.011165649,0.0127913505,0.04153567,-0.011015088,-0.06050964,-0.030858755,-0.021429552,-0.08260956,-0.016549468,0.0527889,0.014877152,-0.044788893,-0.0216305,-0.02143,-0.00015563722,0.021086667,0.03290459,-0.07500713,-0.0089839585,-0.0644167,-0.06573988,0.14962289,-0.0660551,0.03707769,0.011720377,-0.085588194,-0.055069428,-0.04918721,0.044873685,0.030267313,0.080636844,-0.036174707,-0.05356123,-0.009620402,-0.017733214,0.09616941,0.05413748,0.0734452,0.092793286,0.00910173,-0.038843468,-0.016318485,0.030542748,0.011817571,0.0326661,0.024571618,-0.084851675,-0.011007929,-0.0027103864,0.024059633,0.07848423,0.020036014,0.07266621,0.049312465,-0.035394493,0.014385991,0.019458484,0.019567963,-0.09579388,-0.036445376,0.032534756,0.0009900903,0.14041628,0.03530977,-0.026624609,-0.032873757,0.008611226,0.008253037,-0.02946271,-0.045650546,0.108433835,0.06451774,-0.050153643,-0.07367705,0.032360025,0.03613505,0.005588363,-0.017259933,0.038310207,-0.07420485,-0.010918539,-0.08747766,2.5167982e-33,0.07812545,0.06830088,0.07740201,-0.041899882,-0.054156702,-0.021869935,-0.08395497,-0.014923617,-0.04846373,0.030631868,-0.0744574,-0.1057707,-0.02404588,0.039538153,-0.049483348,-0.012108404,0.0045758267,-0.004942396,0.00133583,-0.01946631,-0.018441558,0.037639186,-0.08195468,-0.06646584,0.004241443,0.07435524,-0.016137306,0.0071193045,-0.027659345,-0.009986249,0.0033754054,-0.082318276,-0.067129925,0.05395902,0.043420628,-0.0063759084,-0.005235391,-0.042167936,0.025812319,0.016654564,0.026096566,0.04385451,0.02327366,-0.042697452,0.03698328,0.010918005,-0.072219834,0.055563472,0.10685039,0.07968965,0.029335933,0.0057416046,0.13560382,0.04363032,-0.01603366,0.08325869,-0.014830185,-0.015308892,0.019586245,0.04916743,0.0090308925,0.018333826,-0.07126622,-0.016052652,0.0018124173,0.022453738,-0.11302363,0.05281545,-0.01430277,0.11242215,-0.060237862,-0.06215828,0.0052374243,0.023197768,0.030181872,-0.011031835,-0.036350682,0.019053485,-0.0013475952,0.036446866,0.03217233,0.09673888,-0.03205419,-0.011242399,-0.087606676,0.049374707,-0.036786735,-2.8680088e-06,-0.029962163,0.11228612,-0.1034024,-0.05074847,-0.029992871,0.07180656,-0.021923542,-4.771358e-33,0.12744236,-0.03893154,0.016330786,-0.10270536,-0.051184036,0.02914395,0.04284692,-0.031533916,0.012171825,0.050723962,0.06539675,0.02870711,0.08575047,-0.014344186,0.020050282,0.01316126,0.011796998,0.02825278,0.026679443,0.012150987,0.024240313,0.07811264,-0.060738076,-0.013530798,0.038368165,-0.05614031,-0.008078376,0.063518055,0.07256039,0.04723836,-0.026649354,-0.04409086,-0.033595275,-0.001594857,-0.05090288,0.057827406,-0.04914817,0.053337235,-0.041533098,0.02825875,-0.012790183,0.030751243,0.061755795,0.05887504,0.14630093,0.049771182,-0.023458852,0.002185254,-0.04283783,-0.07586342,0.04778568,0.07549389,0.009594162,0.061848,0.05797649,0.056794707,0.01751791,-0.0021184555,0.008479037,-0.06576509,-0.10383428,-0.039658155,0.017645426,-0.09213569,0.02140086,0.03405218,-0.04096269,-0.019948784,-0.045528665,-0.00039268658,0.017691957,-0.032785434,-0.05388739,-0.006944281,-0.020119779,-0.047416415,-0.12469884,-0.030696526,-0.037093673,-0.01247773,0.050548315,-0.018729629,-0.014660818,-0.07455319,0.025612867,-0.0753827,0.006206323,0.06405861,0.013486669,0.042532507,-0.03794634,-0.028487016,-0.004500129,0.07391481,-0.049195576,-3.298937e-08,-0.029740872,0.004993201,0.03708191,0.01935297,-0.032211766,0.070063904,0.02223639,-0.015763719,0.003929391,-0.008046456,-0.015467562,0.028643385,0.024330283,0.04619515,0.005846652,0.031094363,-0.02799573,-0.002371473,0.056076057,-0.023016097,-0.06573016,-0.01000832,-0.08525697,0.02015817,0.011708187,-0.06385882,0.073731594,-0.031293243,0.0026893257,0.03121946,-0.00499662,0.09063474,0.0048798313,-0.042342447,-0.03365723,-0.009871856,-0.079759166,-0.018653052,0.02663441,-0.005061357,0.059472416,0.019108629,-0.056486852,0.030092752,0.011482319,0.034641035,0.015402851,0.07724088,-0.036814507,0.027650287,0.07687008,-0.070367806,-0.024086809,-0.05604814,-0.051084533,-0.00028863247,0.053173758,-0.07002889,0.0430046,-0.029674986,0.008166648,0.010807532,0.15078546,-0.03701892 +2.8.2.39,"The enzyme, charaterized from the plant Arabidopsis thaliana, also acts on 11-hydroxyjasmonate.",384,1.0,-0.07980528,-0.06867855,-0.046701945,-0.014158693,0.032360576,0.07658012,-0.06650384,0.015169594,0.0049758684,-0.019710157,0.07235821,-0.026414514,-0.060702674,0.0049731643,-0.0484007,0.05133595,-0.015738586,0.047316525,-0.06079633,-0.026905699,0.110026374,0.03716729,-0.0018904298,0.005928811,0.044039954,-0.0064910245,0.04878663,-0.031670414,-0.042208668,-0.076411486,-0.05235807,0.039099548,0.047907602,-0.04155106,0.010651172,0.10573719,0.011485523,-0.11755092,0.11273192,0.010857736,0.04857864,-0.041737717,-0.017391242,-0.03485278,-0.07514212,-0.036495194,0.03193138,0.018036291,0.044058777,0.008564758,-0.063317366,-0.030555421,-0.041680902,0.037056465,0.019577373,-0.051102232,0.036975216,0.01872022,0.0061306097,0.048280653,0.03691877,-0.0023950785,0.03301869,0.044503383,-0.030018121,-0.09078585,-0.009506779,0.000120171055,0.0005395826,-0.06438297,0.014213273,-0.039259374,0.019637777,-0.024981279,-0.030909942,0.06527597,-0.025108542,-0.03154097,-0.0025642866,-0.0054475074,0.022615785,-0.011497233,0.03725199,0.08508812,0.03856972,-0.062061045,-0.02462994,0.059766326,0.03727241,0.07356731,0.0035444389,0.020580512,-0.022685613,0.0019298496,-0.060955364,0.032753337,0.086423315,-0.04227606,0.002885681,-0.029505678,-0.03206706,0.014485411,0.022085806,-0.09497691,-0.025219025,0.030828439,-0.031297866,0.03053528,0.024579687,-0.050408136,-0.040804293,-0.00584384,-0.023025354,0.018474275,-0.055531804,0.07350809,0.034824677,-0.030978804,-0.09217499,-0.018222343,-0.008801704,-0.051876936,0.032221433,0.023954418,-0.09197853,0.038676847,-0.14005528,-3.52239e-34,0.09723948,0.006695198,-0.08088731,-0.018674655,0.008210301,-0.020874122,-0.09091575,0.06611905,-0.042958796,-0.057168566,-0.028461693,-0.032410286,0.018867554,-0.0032608672,-0.041244645,-0.036316212,-0.06259739,-0.07012753,0.04902906,-0.02034951,0.02872732,-0.019585717,-0.13108923,-0.012853381,-0.093160324,0.025493069,0.039261602,0.021577751,0.021378681,-0.009309456,0.0022780688,-0.1299129,-0.053331293,0.0036247121,0.09366582,0.012752564,0.022658564,-0.018794179,-0.029146869,-0.051630657,0.0037904433,0.031136034,-0.0043148655,-0.062158186,0.081963025,-0.01737451,-0.055225912,0.06750713,0.105435245,0.07650794,0.030166019,-0.01239891,0.1358994,-0.03717737,-0.053771026,0.016080232,-0.0047191065,0.02883374,-0.0067682094,0.036551658,-0.021640087,0.019363174,-0.012523304,0.07116321,-0.033221345,0.040069222,-0.036436222,-0.043801196,0.020435603,0.08416437,-0.060687654,0.00015514877,0.037209548,0.06159216,0.01737065,-0.03283695,-0.008137495,-0.0071540624,0.028125448,0.06072536,0.051287826,-0.026928559,0.024532797,-0.015984738,-0.075455986,0.019466043,-0.04020834,0.0007552232,-0.069573104,0.03239238,0.13979234,-0.07773861,0.004150093,0.018743785,0.04954705,-1.6803146e-33,0.070020854,-0.06274006,0.046815943,-0.07585894,-0.03773395,0.063130274,0.020692082,0.010103469,-0.03455026,-0.015011405,0.05580438,0.033593904,-0.016523385,-0.039124772,0.008603651,0.025873838,0.048843633,0.003071165,-0.014938509,-0.011060295,-0.018623617,0.056864,0.01865203,-0.004704816,0.03339367,0.023884114,0.0052275998,0.073162295,-0.0071278266,0.07767048,-0.024439547,0.000604144,-0.07522282,0.023204803,-0.05195332,0.03185474,-0.08110195,-0.016206129,-0.00073096575,0.030756777,0.0460458,-0.030118806,-0.016460221,0.11755269,0.014919334,0.062226348,-0.052564085,0.016512593,0.0038809069,0.030763896,-0.005713317,0.05938069,-0.019698095,0.04595099,0.011317188,0.029287478,0.033561617,0.001815873,-0.022999652,-0.007541316,0.008752505,-0.036235746,-0.0076059825,-0.030091066,-0.0116249565,0.092944995,0.01767775,0.023269922,0.024322506,0.04341439,0.107384235,0.056222662,-0.025384963,0.055289764,-0.018521246,-0.04570417,-0.026431782,-0.02981635,-0.11588541,-0.024276916,0.091107145,0.064170405,-0.037421092,-0.09649869,0.06482834,-0.0662063,-0.0020885118,0.123863734,0.0040818485,0.07113455,0.020704256,0.0045801178,-0.08332424,0.015953165,0.07090087,-2.6097728e-08,-0.084398165,-0.057550676,0.06476632,-0.09838748,0.016826618,0.023638526,0.009066256,0.036216073,0.08390658,-0.05269968,-0.01514292,0.07682342,-0.01324603,0.057144478,0.027327279,-0.09683601,0.016607124,0.05836417,-0.031748638,0.0378124,-0.07232403,-0.0013972329,-0.1071191,0.048293393,-0.031879615,-0.047611076,-0.023359938,0.01628456,0.048621897,-0.02772488,0.012759203,0.054314613,-0.044459447,-0.091875374,-0.14209887,0.07212528,0.031500906,-0.041234676,-0.063166104,-0.005871194,0.032201603,-0.016447628,-0.08778914,0.016218182,0.034026373,-0.011333375,-0.06258719,-0.00027188633,0.055620432,0.030663982,0.08750157,-0.01541198,0.012430254,-0.06957961,-0.13234521,-0.016840255,0.02782605,-0.028478373,-0.05917217,-0.026839597,-0.0053883814,-0.019007882,0.19623972,-0.04049879 +3.1.3.105,"The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway.",384,1.0,-0.05927139,-0.017168162,-0.09207763,0.014105763,0.029518519,0.053038377,-0.11085204,0.05531815,0.019832443,-0.02012107,0.01625287,0.010527459,0.037454404,0.0824189,-0.09367647,0.028762875,-0.052018166,-0.033837203,0.015259288,0.022650743,0.05087156,0.057614136,-0.07312369,0.052658428,-0.029414041,0.020178042,0.04477757,0.009727065,-0.012330461,-0.0032989534,-0.0722357,-0.0668453,0.085954204,-0.040593874,0.102701515,0.09176814,-0.013261077,0.041264728,0.12835513,0.039786454,0.05518829,-0.007249517,-0.03988833,-0.0562312,0.024674527,-0.02155794,-0.018725434,0.019935789,0.099589154,-0.048737578,-0.09731571,0.00050735875,0.011355741,0.04252738,0.032165978,0.078510016,-0.003236478,-0.03094824,0.003506653,-0.0056034904,0.0040842053,-0.023058113,0.008654068,0.022329805,-0.031906866,-0.09253332,0.0038709065,0.009026896,0.06691517,0.014900307,-0.044813607,-0.036495853,0.008525535,0.038136244,0.06873867,-0.04055131,-0.023205202,-0.030395245,0.022307307,-0.004140254,0.023305595,-0.027588343,0.06029262,0.043472666,0.0003994598,-0.017443623,0.054127656,-0.014739567,0.06479441,-0.008259265,0.018293917,-0.074134484,0.015700664,-0.042541284,-0.051274955,0.014298313,0.008574174,-0.018822888,0.065988645,-0.03637282,0.010103564,-0.015121278,-0.024472171,-0.14314996,0.0104313325,0.050883494,0.009764525,0.10138746,0.1142713,0.01664554,0.021918986,-0.0070283506,0.018114457,-0.028050171,0.020492101,0.11966777,-0.014155945,-0.057614494,-0.027691985,0.0010786289,0.016679376,-0.015542482,0.036273822,0.06864942,-0.0067848032,0.024947748,-0.08587229,-2.5965948e-33,0.038200807,0.004642367,-0.029671801,-0.025235137,-0.007937795,-0.00831298,-0.070645355,-0.02374238,-0.01674331,-0.09491916,0.008771061,-0.02362005,-0.05633766,0.06721424,-0.06914793,0.024792401,-0.032613408,0.008174715,0.011200919,0.012947037,-0.008197581,0.027540447,-0.054598715,-0.018228522,0.12044123,0.0719227,0.049035423,-0.017649073,0.022072896,-0.011527757,0.004759893,-0.009485659,-0.11498442,-0.006807075,0.020074006,0.03196811,0.014927782,-0.03621986,-0.015723694,0.06572834,0.013452504,0.04999347,-0.012988366,-0.024593897,0.08230521,-0.052769933,-0.047907162,0.16138792,-0.0076405634,0.070896134,0.030297369,-0.060959622,0.11274999,0.01354207,-0.13037632,0.0069425534,0.0044512795,-0.02700184,0.048787523,0.040508542,0.0784027,0.035724144,-0.0253381,0.03160542,0.010512486,-0.040152945,0.008320338,0.047875315,0.011201657,0.07040572,-0.1226732,0.022634491,0.0529684,0.034539692,-0.01456182,-0.11869378,-0.047970656,0.0166181,0.0056174803,0.02979272,-0.043887597,-0.05041038,0.027200516,-0.016547922,-0.082917914,0.010309084,0.0046906793,-0.063329205,-0.059099883,-0.004575549,0.032612253,-0.06999591,-0.0929052,0.11464875,-0.04049916,3.9082377e-34,0.12689918,-0.12830606,0.06634769,-0.021902215,-0.10927981,0.07503321,-0.0435908,0.03694874,0.042469084,-0.047542594,0.012565775,-6.001116e-05,0.0528153,-0.019248128,0.026875095,0.04210709,-0.025967214,0.014264536,-0.07829077,-0.00871701,-0.03241069,0.010895272,-0.06443205,0.006504232,0.030977082,0.03240606,-0.03478863,0.08987756,0.010744428,0.0318537,-0.0009457457,0.013162122,-0.08252035,-0.059847467,-0.04656915,0.07954631,-0.049623694,-0.03766975,0.007881617,-0.020730998,0.06476931,0.03434641,-0.05333649,0.098074764,-0.027113004,0.10097657,0.020801714,0.0011590341,0.024275806,-0.07661244,-0.0070277033,-0.010973429,0.03159283,0.069808066,-0.019338366,0.012591782,-0.048985135,0.019238885,-0.056600325,-0.044035047,-0.030431842,-0.04089114,-0.02669676,0.027987126,-0.0021555151,0.043776,0.023504494,-0.0058478215,0.0152747445,0.0034459974,0.034146383,0.05357437,0.023092715,0.050745405,-0.05133002,0.08411131,-0.10868018,-0.06276158,-0.026164835,0.029679812,0.001081199,-0.02310836,-0.011857197,-0.075954236,0.008779204,-0.051998816,0.009624714,0.102838546,-0.020877508,0.023388065,0.021727802,-0.027571144,0.021332614,-0.021299923,-0.0066642775,-2.3876758e-08,0.039706193,-0.04401795,0.0012670368,-0.018376105,-0.007354445,0.035584096,-0.052104402,-0.0061670667,-0.042481598,-0.033556685,-0.05888018,-0.026314748,-0.06561742,-0.0095498385,-0.00747589,0.054664925,-0.04329883,0.032949653,-0.00072026515,0.037410233,-0.16763015,-0.039608307,-0.100803725,0.065774865,0.003268389,-0.008644528,0.08036537,0.03841202,-0.034395598,-0.015315391,-0.045752477,0.010803347,-0.037789498,-0.0072664088,-0.067288265,0.026590163,-0.0051780567,-0.044952855,0.015351803,-0.06493619,0.097419776,-0.003142054,-0.0948899,-0.071244195,-0.0028301047,0.0069581363,-0.010202183,-0.016391322,0.014015087,-0.06430037,0.060684618,0.012582559,0.01868349,-0.0130270375,-0.099122,0.041798458,0.001657488,-0.054922547,-0.0049733752,-0.007933338,-0.008475828,-0.0015535691,0.19618396,0.023248235 +3.1.4.58,"The enzyme hydrolyses RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. In vitro the enzyme can also ligate tRNA molecules with 2',3'-cyclic phosphate to tRNA with 5'-hydroxyl termini, forming a 2'-5' phosphodiester linkage. However, the ligase activity is unlikely to be relevant in vivo.",384,1.0,0.011074736,-0.08793147,-0.04094332,-0.087522976,-0.030152088,-0.061307576,-0.057992164,0.009334409,-0.05974281,0.08202651,0.04661649,0.0308171,-0.043893524,0.10973529,-0.046255235,0.08307076,-0.1145845,0.0043504466,0.05684473,0.010873695,0.08701444,0.040463697,-0.064466976,0.024999885,0.0092868395,-0.031436965,0.071248986,-0.045953054,0.008483629,-0.016753739,-0.14095128,-0.03288035,-0.03203179,-0.032460626,-0.03945691,0.067661926,-0.06960222,-0.0056938785,0.017120076,0.051352736,0.0933471,-0.035975657,-0.036310814,-0.066343874,-0.05218309,-0.028702572,0.03297344,0.08031016,0.01637921,0.084406085,-0.045288764,-0.05590605,0.00978731,-0.015955247,-0.03862504,0.09425653,-0.066425584,0.025293538,-0.0359186,0.038317908,0.046667878,0.01527677,-0.00545997,0.009569855,0.09202325,-0.07138962,0.037618157,0.026573697,0.014014241,-0.0021365618,0.011176714,-0.047489576,0.026147211,0.021872811,-0.02291228,0.043466326,0.013461156,-0.028616907,0.028416352,-0.010227861,-0.036695685,-0.056488704,0.05925719,0.026407782,0.013915233,0.055846665,-0.05994308,0.040891755,-0.029847516,0.06519587,0.05077211,-0.038094714,0.03362357,-0.029201098,0.009712569,0.03522141,0.005892622,0.034521226,0.039872013,-0.055808946,-0.0012996971,0.05438886,-0.051803265,-0.05996527,-0.014555483,0.02616032,0.00072862144,-0.05949103,-0.027298585,0.056858037,-0.041828275,0.041718014,0.054051846,-0.077913426,-0.02599331,0.030588856,-0.037015576,-0.045634784,0.10204832,0.041554593,0.019897563,0.011465566,-0.0041663577,0.043124072,-0.01431331,0.04604318,-0.038927265,1.0343798e-33,-0.010542815,0.015490155,0.034228127,0.04549743,0.017744804,0.04242674,-0.06487561,0.014417096,-0.087350264,-0.10758619,-0.07193533,-0.029193833,0.007984545,-0.023156125,0.036577106,-0.03685217,-0.022561034,0.039895345,0.044501018,-0.0011058816,0.020700023,0.0072415965,-0.060929533,0.050705813,0.04108514,-0.0010333855,0.010764624,0.0034864894,0.060162507,0.008820574,-0.022090081,-0.049549576,-0.042039994,-0.006672497,0.058769297,-0.05538043,-0.04071944,0.00075873925,-0.08868382,0.1099485,0.02430011,-0.09051371,-0.012637356,-0.013542409,0.014851551,-0.044459682,-0.009873195,-0.008444044,-0.03841272,-0.01929808,0.05769368,-0.012043587,-0.02295455,-0.018943096,0.008176515,-0.029392561,-0.026031882,-0.08496134,0.023522068,0.020902487,-0.051667906,0.044949,0.033543758,0.061467193,-0.07847639,0.01677154,-0.055946838,-0.10793641,-0.007002713,0.048180822,-0.047923554,0.0025399344,0.09503514,0.012874564,-0.021420954,-0.017504262,0.048536237,-0.035310153,-0.051377196,0.039136626,0.027543226,-0.047469907,0.082009,0.06123585,0.0645049,-0.048031956,0.048263356,-0.08366934,-0.026157333,0.054111462,0.05328147,-0.013692913,-0.053368423,-0.0036058587,0.046468616,-3.4472753e-33,0.06032524,-0.05974091,0.09442335,-0.052947942,-0.082508184,0.045758877,0.03189896,-0.045806035,0.012052865,-0.043499656,0.08540671,0.025678253,-0.018013747,-0.025526926,0.022598013,-0.023374204,0.03816533,0.026351437,0.006344042,-0.026543232,0.076408684,0.014655929,0.031730548,0.039616924,0.065297775,-0.07868422,0.0049764155,0.090723306,-0.036714725,0.117141284,-0.016561657,-0.038103413,0.05494576,0.043506682,-0.011131625,0.035516165,-0.063084334,-0.015307259,0.07730245,-0.008836096,-0.019101074,-0.009451415,0.040631384,0.007116331,-0.03804548,0.032564785,-0.0013787311,-0.051028464,-0.039208412,-0.047450375,0.08571312,-0.0013942325,-0.011492733,0.04064856,0.02381909,-0.034941696,-0.028964238,0.07345081,0.010967913,0.010669256,-0.039240282,-0.06731757,-0.0059314314,-0.030597098,0.0692298,0.030208414,-0.015289397,0.061261132,-0.0267754,0.005039436,-0.022238817,0.011369679,0.008176812,0.09196032,0.039945494,-0.02932532,-0.084512085,-0.011339561,-0.0061787204,-0.049573224,-0.058062635,-0.011805083,0.00932321,-0.072644256,0.09622946,-0.083374865,0.030822506,0.14046319,-0.0007374035,0.09062593,0.046920676,-0.007739671,-0.052001856,-0.047068328,0.044199627,-3.952222e-08,0.012206898,-0.0537369,-0.0038866522,-0.10756023,0.022956694,0.047247645,-0.021149956,-0.00042973325,0.07114828,-0.007521735,-0.018799488,-0.016994748,0.003719406,0.009850253,0.109252736,-0.0034730688,-0.109575115,-0.012517506,-0.030133659,-0.05499699,-0.0979906,0.10560147,-0.17225805,0.073534206,-0.041090026,0.05602191,0.035234835,0.03152402,-0.001436847,-0.010061756,0.018162876,-0.025173683,-0.012556873,-0.037950303,-0.15216972,0.04266957,0.03188321,-0.013760709,-0.09176006,0.05996351,0.005776497,-0.027800571,-0.023404492,0.022255905,-0.030449295,-0.014921503,-0.02122832,0.060398184,0.0020576015,-0.020361809,0.06638639,0.057354353,-0.011120294,-0.0605778,-0.045781236,-0.078446746,-0.009429081,-0.08898842,-0.101722345,0.0015287856,-0.016064549,0.040765483,0.19221915,-0.04592125 +3.1.7.12,Isolated from the bacterium Herpetosiphon aurantiacus.,384,0.99999994,-0.07168087,0.022292994,-0.07056518,0.004905471,-0.036368936,0.034221753,0.011758656,0.055720057,0.0053852727,0.035711,0.012731792,-0.08056944,-0.0073211356,0.062048033,-0.07320638,-0.00421641,-0.037380733,-0.029102257,-0.015480688,-0.0003970297,-0.007890496,0.0822473,0.007383667,-0.03764311,0.043041836,0.033436652,-0.04628067,0.04583371,0.028150413,0.0011020614,-0.06782109,-0.05952694,0.03167438,-0.04811836,0.08207946,0.05112286,-0.0426574,0.0121989595,0.13563456,0.022639418,-0.02162432,0.044494435,-0.02587782,0.015427399,-0.023045085,0.032312892,-0.07493104,0.026460988,0.07607523,0.0160272,-0.0062707085,-0.020982495,0.0039790547,-0.0036461982,-0.08323505,-0.07070697,-0.009618272,0.01344464,0.010429869,-0.04760498,0.09833382,0.015298821,0.049556185,0.06949534,0.0019617188,-0.0040285615,0.023846224,0.008210217,0.10288853,-0.020499082,0.057206262,0.008431832,0.02839204,0.06967347,0.012523282,0.058239777,0.03546454,-0.023488551,-0.0044141016,0.036628846,0.02469326,0.026709551,-0.013789626,0.059082787,0.00981094,-0.012916932,0.04574138,0.008897009,-0.036710557,0.03229134,-0.036443446,0.0027195555,0.014410456,-0.11462211,0.009762922,-0.028715212,0.020375624,0.006321297,0.055716448,0.0043066926,-0.020294774,-0.025202358,0.023204805,-0.0639457,-0.03377854,-0.0041831904,-0.06360916,-0.09188406,0.10006461,-0.007684048,0.0035482238,0.017313674,-0.0997395,-0.052737925,0.080726296,0.076673925,0.039819837,-0.06251116,-0.040013753,0.00269118,-0.018533459,-0.11287355,0.07664084,0.0029644377,-0.036655635,-0.012452473,-0.054937795,8.5248853e-35,0.021115715,-0.0351726,0.04375735,-0.06657108,0.06408212,0.08186928,0.047513213,0.00033179997,-0.09601441,-0.00012839216,-0.10408057,-0.023929076,0.06581301,-0.037472118,0.020613015,0.03339102,0.036147255,0.00019306893,0.087685145,-0.039125107,0.03235644,0.11278859,-0.0040663253,-0.02297638,-0.0037873802,-0.00034002267,-0.0005638998,0.0033954163,0.053253435,0.005812735,0.018307898,-0.09414194,-0.06874146,0.046832137,0.022814024,0.026028395,-0.112582065,-0.05259088,0.012824382,-0.018138494,0.07009903,0.015097638,0.038690526,0.02103249,0.046909235,0.014630307,-0.09338062,-0.044225715,-0.001820517,-0.007979378,-0.07416092,0.052704297,0.08791365,-0.09004777,-0.05668894,0.015848191,0.05860351,0.022828605,0.005241045,0.067688316,0.046102185,0.13630691,-0.03273388,0.051249754,0.078192875,-0.009392397,-0.07137332,-0.045928746,-0.046358626,-0.04024065,-0.021280892,-0.045949902,-0.02875629,-0.060739107,-0.025477942,-0.00774548,-0.013577777,0.004189306,-0.090540975,-0.10786483,-0.073134996,0.0049784877,0.065086834,0.029947605,-0.040307354,0.08164843,0.0196164,-0.022175517,-0.01611767,0.07941457,0.08744285,-0.00053251145,-0.06500532,-0.020028166,-0.04288105,-1.8035928e-33,0.0809238,-0.02443382,-0.02390859,-0.056960046,-0.059981093,0.12201893,-0.018186152,0.11653885,-0.033960134,0.004557597,0.03721836,-0.013035014,0.025492601,0.0042541525,-0.010661348,0.06180675,0.09145366,0.0974228,0.021425901,0.041342955,-0.066513866,-0.01823736,0.04470353,0.012718561,-0.047324426,0.03255366,0.07350739,-0.01948341,-0.03575098,-0.015189124,0.010161529,0.046687666,-0.07028565,-0.107547686,0.01741063,-0.020820804,-0.061692625,-0.14029698,0.061781883,-0.033736486,0.022843298,0.02582486,0.0017062834,0.046041694,0.053873003,0.07640587,-0.047297813,0.06786461,-0.040382087,-0.005803356,0.012951686,-0.010262544,0.027321098,-0.0075028236,0.05149467,-0.059415992,0.029025307,0.025537416,0.022050885,-0.02791916,0.052800704,-0.055730145,-0.0437575,0.017258627,0.058042023,0.06270013,0.010655819,0.0003555908,-0.08286,-0.06819564,0.024660438,-0.008624479,-0.02170531,0.05812946,-0.053176176,0.055118788,0.02745313,-0.091779985,0.11933531,5.7364316e-05,0.03345466,0.0031076092,0.03645475,-0.06668634,0.02379681,-0.12468842,0.013645397,0.010673764,-0.026163328,0.0018491739,0.026158648,0.022046346,-0.06471749,-0.075562395,0.113641344,-1.8998664e-08,0.1475503,-0.024478454,0.04094887,-0.013424364,-0.018970974,-0.048324276,0.048801266,-0.04369487,0.03961114,0.026461255,-0.03683796,-0.05930373,0.023570377,0.0050884425,-0.0039644847,0.005920002,-0.01260841,0.024540436,-0.024143022,-0.008769429,-0.09834787,-0.015752755,-0.022893833,-0.022729134,0.0031804636,-0.0652359,0.116126254,-0.051843338,0.051599,-0.0662561,-0.068041965,-0.016928226,-0.0453653,-0.07490357,-0.05771551,0.027639767,-0.0756865,-0.0070041553,-0.0021537964,-0.046499595,-0.037088066,-0.01036584,-0.033746194,0.008386588,-0.012468732,0.0056879004,0.008175274,0.0050761593,-0.051008593,-0.05806573,0.0048845178,-0.023693325,0.056563355,-0.053227387,-0.11073429,-0.033656277,0.046273973,-0.042235192,-0.08823553,-0.011932412,-0.04930646,-0.023611741,0.104769506,0.06739427 +3.2.1.204,"The enzyme, characterized from the bacteria Bacillus sp. NRRL B-21195 and Kribbella flavida, participates in the degradation of starch. The cyclic tetrasaccharide cyclobis-(1->6)-alpha-nigerosyl is formed from starch extracellularly and imported into the cell, where it is degraded to glucose.",384,1.0,-0.060348004,-0.010392537,-0.13528451,0.005179701,0.023561105,0.023682967,0.008895043,-0.0153996805,0.022082467,0.051286396,-0.01865546,-0.054877773,0.004898306,-0.014723128,-0.09604684,-0.020674499,-0.024949487,-0.0019219366,0.0031542846,-0.0021030328,0.03581826,0.039596923,-0.018741012,0.025979623,0.039370157,-0.048784364,0.01867632,-0.08496936,-0.05774948,-0.021037102,0.02995426,0.025799474,0.061938424,0.036954757,0.0634263,0.078201555,-0.008625039,-0.064763494,0.062272914,-0.06691604,-0.014154202,-0.04552597,0.01815876,-0.038028784,0.010203966,0.056180213,-0.0554638,0.013387332,0.024363637,-0.05548803,-0.024667654,-0.08520463,-0.08241654,0.13037993,0.0407047,0.060768433,-0.059233155,-0.04679298,-0.0176224,0.04656583,0.07931019,0.055765346,0.02410373,0.049575843,-0.0032827216,-0.107618816,-0.023302954,-0.06844155,-0.040645838,-0.009632511,-0.09117109,-0.038119044,-0.00830891,0.018299542,0.0006241155,-0.008625312,0.04376963,-0.043649804,0.016842287,-0.04836281,0.046270393,0.018267158,0.058212858,0.076419316,-0.032403104,-0.099377565,0.06677418,-0.019891242,0.05501326,0.030285023,0.082060345,0.07684838,-0.015780006,-0.0056239674,-0.09321347,-0.033951905,0.020750102,-0.03636365,0.12185488,-0.009258864,-0.073560975,0.011913203,0.055270437,-0.066825666,-0.07264342,0.030480307,0.04358239,0.032585084,0.06726685,0.07412414,0.011424058,0.04791249,-0.027727697,-0.036478713,-0.035254963,0.045957074,-0.017793618,-0.04564835,-0.045344893,0.013254925,-0.008289598,-0.03800997,0.054782476,0.053342864,-0.055807985,0.100507475,-0.007969329,6.8717623e-34,0.061195463,0.008686082,-0.013270426,-0.041407008,0.020999182,-0.008507668,-0.037916392,-0.02928265,-0.00093546195,-0.06401283,-0.0684515,-0.060043402,0.028310005,0.044821292,0.05797301,0.0590899,-0.08951128,-0.026732758,0.06461294,0.059869863,-0.031026753,0.090998136,-0.012010912,-0.03273152,0.057702713,0.06366177,-0.010496995,-0.039621107,-0.017562011,0.028669473,0.080802076,-0.021676648,-0.110105604,0.02289846,0.07986789,0.012661927,-0.051515806,0.027113495,-0.0180911,0.035557132,0.027536321,-0.014534064,-0.02833721,-0.063448034,0.04736955,-0.060005,0.028064473,0.12156538,0.042474713,0.051499125,0.056290343,-0.052520335,0.01086929,0.04385519,-0.049198546,0.0847917,0.0095982365,-0.053650983,-0.00015676771,0.016416462,0.034798067,0.06146271,0.00097172573,0.06228829,0.038009103,0.014955098,-0.053165138,-0.00821132,-0.048654743,-0.052726313,-0.08783105,-0.057740755,0.07666593,-0.01014414,-0.03371896,-0.026227294,0.017504642,0.009408843,-0.0054401015,-0.011890604,0.035611138,-0.05165241,0.019375049,-0.08666086,-0.020755483,-0.015952816,-0.037249308,-0.042266008,-0.038332023,-0.022624223,0.031086208,-0.066078,-0.085053094,0.021054525,-0.021178665,-2.8907952e-33,0.14698918,-0.07041167,0.03421461,-0.015199689,0.018683897,-0.02785054,-0.03377161,-0.06851384,-0.019393528,-0.02124528,0.022310715,-0.011675043,0.0025774671,-0.045414913,0.03288144,-0.042591225,-0.010687681,0.11654999,-0.11209506,-0.09138551,-0.007365537,0.06986484,0.022075336,-0.04756936,0.008277912,-0.0010057227,-0.030616455,0.12013196,0.044834435,-0.0020831558,0.02541357,-0.013139617,-0.020380886,-0.019602776,-0.029329525,0.068003245,-0.04862452,-0.023566673,0.059878692,0.0019023201,0.06516549,0.09428461,-0.01960954,-0.01484119,0.054745045,0.081471026,-0.07443748,0.028689973,0.03203004,-0.056131545,0.053023215,-0.030452633,0.021205252,-0.010051514,0.015091395,0.09768719,0.03381182,0.07576129,-0.041341145,-0.042472225,0.0036240646,-0.024681367,0.111590505,0.014926233,0.07448574,0.018008996,0.024277572,0.06570802,0.066477194,0.0034681002,0.0697609,0.014685982,-0.05842188,0.034831017,-0.03602107,0.044200227,-0.08345187,-0.0045527457,-0.032742333,-0.038367856,0.021073595,-0.002797213,0.06452982,-0.045478355,-0.021035537,-0.026594568,-0.0023408183,0.064183846,0.02083596,-0.02451957,-0.03116695,-0.010563287,-0.006858582,-0.009599266,0.068135336,-3.571864e-08,0.06321615,-0.10815911,-0.043139163,-0.03820823,0.029308544,0.04101174,0.019343773,0.008171742,0.074246995,-0.089680694,-0.04689956,0.113079935,-0.000143975,0.022814486,-0.020171352,0.006045803,-0.06735343,-0.06269503,-0.033430014,0.04774705,-0.101009406,-0.029123612,-0.048327245,0.057495717,-0.058711223,-0.05670799,0.043972366,0.06848739,-0.054507937,-0.046017148,0.018842148,0.1004528,0.015819522,-0.030833768,-0.06924138,0.016017707,-0.010438307,-0.022394622,-0.019740166,0.09436052,-0.031874318,0.03331882,-0.04394729,-0.042631317,-0.06109192,-0.01034727,-0.047377024,0.043506015,-0.057031482,-0.016908899,-0.015849626,0.027988069,-0.15870273,-0.038118288,-0.0710637,-0.019639388,-0.044243757,0.0054875077,0.029861096,-0.03338522,-0.021668885,-0.019365184,0.1520111,-0.02209393 +3.2.1.205,"The enzyme catalyses the hydrolysis of alpha-1,6-glucosidic linkages from the non-reducing end of its substrate. Unlike EC 3.2.1.10, oligo-1,6-glucosidase, the enzyme inverts the anomeric configuration of the released residue. The enzyme can also act on panose and maltotriose at a lower rate.",384,1.0,-0.00470427,-0.0695271,-0.048524007,0.059404917,0.055676818,-0.0052247136,-0.015452045,0.0021075644,0.091283984,-0.027145203,0.018841945,0.062782675,-0.14139923,0.005420674,-0.057363994,0.0060168486,-0.06718678,0.009612524,-0.094054356,-0.060137525,0.12527014,-0.030268036,-0.014867048,0.01843412,0.060212236,-0.101797655,0.025219236,-0.033937808,-0.0020528506,-0.097568005,-0.02254829,-0.07059535,0.03810643,-0.0025607261,0.051587354,0.05321462,-0.01704624,-0.07885569,-0.002782094,-0.0009124801,0.047575966,-0.0063650766,0.0071005514,-0.05657603,-0.08824489,-0.035587616,-0.055928886,0.047457527,-0.014749726,0.018910896,-0.0053283065,-0.0816536,-0.09494983,-0.046536915,0.024845526,0.029507194,-0.0729508,-0.04364277,-0.030150991,0.07909492,0.048937067,0.07771609,-0.08789627,0.048470378,-0.024107875,-0.11625392,0.13727863,-0.071877345,-0.07739689,-0.019753797,-0.08338983,-0.07311265,0.023186352,-0.03857714,0.041757416,-0.0014173324,-0.0637755,-0.011588385,0.053185515,0.0012018642,0.05964514,-0.047525816,0.033137385,0.08812964,-0.0025060424,-0.020077236,0.015411896,0.00847868,0.057242803,0.027469972,0.009903238,-0.014246038,0.020544617,-0.043722663,0.025463294,0.042301275,0.012785415,0.017440643,0.04744261,-0.00098337,-0.0050878786,0.09775757,0.011504319,-0.010447504,-0.019784508,0.106586784,-0.010932871,0.15600246,0.03791575,0.041124098,0.016190672,-0.004856625,0.09881625,-0.016462533,-0.03212122,0.05654171,-0.0037691393,-0.045120582,-0.005937845,0.0013461035,0.06994531,-0.010425897,0.061708484,0.087151766,-0.09293412,0.09716856,-0.0027468074,8.439825e-34,0.06475035,0.028475724,-0.002506871,-0.098970205,-0.03867698,0.021621041,-0.08271183,0.005275691,-0.06923954,0.04970472,-0.10446894,-0.0051506707,0.025283212,0.052772064,0.02067281,-0.01980517,0.05113869,0.024617733,0.032996804,0.03439564,0.017846515,0.042481344,-0.060315713,0.006665115,0.037528194,0.04827416,-0.0880961,0.029067231,-0.035958085,-0.015913527,0.034939986,-0.015385709,-0.07881954,0.064236805,0.0040173884,0.020912508,-0.029943492,-0.004807372,0.013313704,0.04023936,0.016946342,0.021983646,0.0011316906,-0.05907099,0.04048768,-0.06654383,0.0075165248,0.07766727,0.010651893,0.07879826,0.004470084,-0.010299159,0.06935775,0.026249025,0.019918222,0.027884372,0.008010353,0.018512938,0.05010394,0.06205732,-0.00080411433,0.064219564,-0.05570922,-0.023766506,-0.028133284,0.019710023,-0.023157177,-0.008972803,-0.047484607,0.06921613,-0.1411044,0.031652417,0.0037034918,0.033602644,0.013468279,-0.06815928,-0.056495592,0.0061497083,0.0067925425,-0.044704463,0.0032136235,0.021703774,0.074383564,0.010794372,-0.08875291,0.037131477,-0.040661696,0.0048226966,-0.02227885,0.018265069,0.0353267,-0.055575296,-0.07243474,0.059451614,0.042521596,-1.7820766e-33,0.104031384,-0.088966385,0.007954158,-0.081267394,-0.07284791,0.027545666,0.09416663,-0.037669808,-0.020589154,-0.04728306,-0.0052679894,0.04040193,0.019310819,-0.049490854,0.020481974,-0.033141628,-0.045325454,0.07566048,0.025302397,0.013423789,-0.024344534,0.06518582,-0.0136998575,-0.007014797,0.08928385,-0.013760433,0.04247261,0.020705974,0.020646228,0.014093405,-0.00010099971,-0.03186584,0.046156257,-0.080386944,-0.00011814252,0.09940365,-0.073792726,-0.008836454,0.023360299,0.014025375,0.022198735,0.039138533,0.024401529,-0.002398773,0.089288406,0.091379344,-0.09355853,0.03511704,-0.049141537,-0.0400305,0.0077954377,0.006559949,0.012226415,0.04529351,0.044222984,0.013079044,0.064815275,-0.078258134,-0.04536946,-0.0003742514,-0.037504405,0.029665334,0.043221496,-0.004425732,0.058491282,0.035915647,-0.022933476,0.076424316,-0.002654996,0.024310622,-0.02050941,-0.06253091,-0.019440278,-0.02578554,0.010740517,-0.061988123,-0.10949486,-0.012010674,0.0031558715,-0.010677711,0.025624523,0.052866157,-0.0034444067,-0.055467423,-0.0029180958,-0.08148341,0.053486984,0.10110073,0.05329128,0.07800531,-0.0431372,-0.013588519,-0.02034864,0.0054122154,0.07046975,-3.7962614e-08,0.036852974,-0.08028975,0.05209111,-0.048974115,0.0007294529,0.049985137,0.03655387,0.018356094,-0.012416954,-0.017331934,-0.041995473,0.094748326,0.0025967432,-0.0068853186,-0.008490241,0.00101676,-0.021238284,-0.004527498,-0.015802996,0.0164501,-0.089740336,-0.023676887,-0.07409994,-0.012093609,0.027476918,-0.10911896,-0.011144167,0.06231874,-0.03466551,0.026957247,-0.039295737,0.039593637,0.013114448,-0.023682749,-0.058584776,0.069333,-0.025326917,-0.033094976,-0.048307136,-0.014515306,0.026989682,-0.07150247,-0.051366434,-0.041964296,0.030658312,0.036976274,0.033084717,-0.04086503,-0.014991427,0.060612008,-0.015666002,-0.05016021,-0.0614922,-0.016468477,-0.023866136,-0.08598845,0.0020881968,-0.046155445,0.023554496,-0.04372918,0.031953607,0.02187668,0.21179795,-0.065492116 +3.4.19.16,"This enzyme, characterized from the plant Arabidopsis thaliana, participates in the biosynthesis of the plant defense compounds glucosinolates and camalexin. It is the only known plant enzyme capable of hydrolysing the gamma-glutamyl residue of glutathione in the cytosol.",384,1.0,-0.07133307,-0.016629046,-0.12114699,-0.0057888953,0.06623708,0.06408268,-0.01601791,0.09823571,0.020607902,-0.03925014,0.08379724,-0.008903147,-0.008396782,-0.019844268,-0.09403468,0.0238597,-0.010617798,0.03854166,-0.09208094,-0.10849373,0.054250147,0.06439064,-0.05560481,0.011499194,0.041314155,-0.00922272,0.018147424,-0.02258861,0.0027861318,-0.03111204,-0.061694536,-0.072863154,0.025080992,0.0052898354,-0.0016284623,0.0964684,-0.04696293,-0.099816896,0.08178508,-0.030234909,0.010804087,0.0037742157,-0.017161218,-0.06089655,-0.012771565,-0.025171096,0.02512426,0.0046371,-0.010897543,-0.0474989,-0.008653193,-0.035455775,-0.0065117367,0.0037945732,0.026289938,-0.012125659,-0.011582492,-0.06829038,-0.030457616,0.08333373,0.011488973,-0.031094052,-0.039759457,-0.051980756,0.020955287,-0.046368744,-0.008422606,-0.0013752461,0.014896549,-0.043120943,-0.027872767,-0.03959729,-0.025659164,0.020833272,-0.032805502,0.061268024,-0.055341426,0.030411614,0.07638531,-0.02378448,0.11444126,-0.03411434,0.09061931,0.12937999,0.041740455,0.011507033,-0.0046890406,0.09576433,0.10813992,0.025627611,0.033995297,0.007509475,-0.012585882,-0.019522112,-0.09217554,0.058756433,-0.020562366,-0.08552896,0.002123012,-0.01917549,0.023578865,0.019199409,-0.026730103,-0.07547647,-0.0313823,0.063400626,0.0037565858,0.03076997,0.024288168,-0.049137905,-0.0424236,-0.00667304,-0.06204033,0.028140888,-0.03133742,0.062170006,0.06436065,-0.034728624,-0.09968592,-0.049057674,0.06423367,0.030210668,-0.009982087,0.027405793,-0.005398456,0.036511026,-0.10073456,3.451955e-33,0.057051346,0.07398937,-0.02948862,-0.054221865,0.025526261,0.01049441,-0.04929678,-0.011451806,-0.043020654,-0.045159638,-0.0792716,-0.05907786,-0.024331527,-0.009412858,-0.011763972,0.037922226,-0.049863324,-0.022088401,0.07596653,0.00050127564,0.033619963,-0.033911142,-0.07294031,-0.0027176342,-0.008208268,0.05341391,0.004728686,0.0074744388,0.021250537,-0.021594511,-0.016269896,-0.08140454,-0.06402541,0.039987903,0.08404272,-0.033114795,-0.055103548,-0.043287307,0.02023693,0.064054206,-0.038220532,0.03471833,-0.012580095,-0.04287398,0.030377218,-0.008731423,-0.05440269,0.045804832,0.054118656,0.08731866,0.031911675,-0.004799997,0.08874741,-0.038227968,-0.06389667,0.04167983,-0.0054373327,-0.007046485,0.035197217,0.071169615,-0.078827865,0.013091454,-0.057451688,0.0033049015,0.007927868,0.05794589,-0.08999775,-0.02483362,0.000987195,0.11385179,-0.036658734,-0.047426816,0.020710278,0.03935889,-0.008754846,-0.053187527,-0.031597853,0.057966515,-0.035972137,0.022908852,-0.020427966,0.009729869,0.013741677,0.033219393,-0.054841407,0.011475214,0.013187863,-0.017260492,-0.010620339,0.042245813,0.07144454,-0.024109619,-0.010912026,0.015871253,-0.030639822,-3.3711782e-33,0.08629709,-0.06173939,0.039947703,-0.0786201,-0.0084548835,0.039618086,-0.008563454,-0.057345092,0.06297429,0.010061347,0.042822685,0.042581778,-0.005582984,0.0051998673,0.017940931,-0.008911283,0.003938565,0.10069497,-0.032056894,-0.0025955623,-0.020260587,0.06182559,0.042430017,-0.013052517,0.064827144,-0.026795441,0.011886724,0.06684566,0.066765636,0.044368703,-0.0049000275,0.0044530323,0.0012511228,-0.06989016,0.018831179,0.0217977,-0.0029994098,0.01723927,0.03526327,0.040059004,0.00094732764,0.055339262,0.024398766,0.076316535,0.022015743,0.11931185,-0.07189698,0.004461049,-0.07856061,-0.06751368,0.026244769,0.024564292,-0.0077420226,0.089480385,0.053818785,-0.023279546,0.021912683,-0.02363885,-0.033908658,-0.00079065305,-0.005835466,-0.07431663,-0.061572004,-0.02694198,0.05956324,0.06462808,0.02344084,0.027075347,-0.029126316,0.056389123,0.12969916,-0.019812223,0.051592518,0.06510597,-0.044273257,-0.030966878,-0.085980915,-0.005197503,-0.07198674,-0.030731834,0.08777357,0.033330154,-0.027678838,-0.09813313,0.0067345984,-0.092829786,-0.0029585261,0.21022494,0.062042803,0.026122453,-0.053991325,0.0043247705,-0.03825559,0.06124501,0.07128276,-3.5759356e-08,-0.049225204,-0.05265506,0.0036121723,-0.07283989,-0.0229926,0.07250079,0.031791985,0.03460327,0.0572151,-0.024441132,-0.023373997,0.10146865,0.010684112,-0.015945164,-0.054485675,0.00011595319,0.025051903,0.056576688,0.0061849547,0.047217987,-0.06482602,0.0029577385,-0.12829931,-0.0038081694,-0.020651832,-0.0631191,0.014578654,-0.014585928,0.02352612,-0.034846734,0.026827116,0.03150657,0.051589567,-0.0664231,-0.12541711,0.034289986,-0.0036533282,-0.0066344542,0.04632183,-0.03663353,-0.01144107,0.010414164,-0.07273165,0.0135972835,0.002137606,0.0050139106,-0.00633322,-0.042107705,0.041200995,0.088845275,0.03719984,-0.033515174,0.020816432,-0.062004384,-0.08898032,-0.030316997,0.032035623,-0.044042863,-0.03998437,-0.08052881,-0.011882492,-0.03438543,0.22775744,0.0025749567 +3.13.1.6,"Requires Zn2+. The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in an L-cysteine biosynthesis pathway. It acts on the product of EC 2.5.1.113, [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.",384,1.0,-0.07735099,-0.011241429,-0.019606719,-0.0073429216,0.093512654,0.042236876,-0.0319716,0.103760295,-0.0042340574,-0.01155703,-0.021562207,-0.016413786,0.05725107,0.056479983,-0.06811954,0.06300251,-0.012223325,0.018158851,-0.004463964,-0.047970768,0.025907274,0.111143,0.005678102,-0.0042546582,0.02640211,-0.018380933,0.06315061,0.0317773,-0.041956715,0.0046570506,-0.056772742,-0.07692506,0.021538613,-0.024092462,0.05742183,0.043888,-0.022774817,-0.07397895,0.062343273,-0.015779214,0.069331735,-0.014528056,-0.00417205,-0.0031364942,0.033993565,0.03183481,0.046823774,0.041749213,-0.022382246,0.03375095,-0.061771773,-0.036158253,0.004631683,0.069915704,0.039374087,0.058689173,-0.12679821,0.03466361,0.012039491,-0.017257683,0.04449849,0.009662046,0.0011514858,0.0026582973,0.08416149,-0.0032272362,-0.039120954,-0.030657891,-0.026641604,-0.03190369,-0.06042509,-0.012935661,-0.07513871,0.058621917,-0.027104268,0.02961824,-0.0038665442,-0.08009002,-0.013582155,0.011362142,-0.007546455,-0.024537468,0.019939743,0.02432745,0.04312165,-0.0343766,0.09580125,0.06664649,-0.03940416,0.08335856,0.067846365,-0.0025222222,0.023912007,-0.0053992346,-0.09409837,-0.00994856,0.07439095,0.09265529,0.02158867,-0.014076972,0.05899312,0.04432525,0.029834863,-0.08203773,-0.040703416,0.0037584882,0.022739215,0.05099089,0.0016917929,0.0042393706,-0.0058947434,-0.04552424,-0.006376857,-0.061940618,-0.011107382,0.12814686,0.052948356,-0.03233081,-0.13667,0.021237452,0.02111049,-0.04283077,-0.04654596,0.058072492,-0.08286362,0.041473057,-0.15272847,9.631994e-34,0.030066006,0.014958168,0.017002432,0.012548196,0.052539565,0.020080745,-0.055036645,0.034271237,-0.043528378,-0.048471928,-0.10010818,-0.08971412,0.023356263,-0.016468927,-0.09137507,0.005798239,-0.047005814,-0.041317802,0.1054068,0.085883394,0.04356076,-0.043147236,-0.043164205,0.034560177,0.023207089,0.08854442,0.04617047,-0.017923389,0.026879037,-0.0027513434,-0.025362086,-0.11514849,-0.067669146,-0.064800546,0.09593086,-0.07735908,-0.0050997366,-0.015999123,0.038059924,-0.022811806,-0.009871491,-0.0026476316,-0.0013588014,-0.013806524,0.06477224,-0.040703468,-0.025837896,0.032136854,-0.004529436,-0.02589336,0.07527538,-0.06393816,0.018288689,0.0064856783,0.009622661,-0.028178718,-0.05191665,0.059250772,0.0077769794,0.022607137,0.064813286,0.0640432,-0.04737008,0.10075806,-0.0432253,0.016347937,-0.078839436,-0.033790704,-0.008822379,0.045908656,-0.013997726,-0.040639948,0.07067534,-0.008913353,0.07663458,-0.027343879,-0.10071186,-0.031196969,0.08456915,-0.023121333,-0.052852895,-0.017143022,-0.045789327,0.0009851262,-0.01842043,-0.098234974,-0.052653715,-0.028525626,-0.030310705,0.012794395,0.018884296,-0.09695614,-0.038317773,0.070503235,-0.041916195,-1.9244046e-33,0.06356072,-0.05871971,0.07601502,-0.09664974,0.00742128,0.003431191,-0.008472051,-0.10063586,0.06716308,-0.01942589,0.07156697,-0.018476548,0.04362539,0.03413492,0.0049373712,-0.0066471244,-0.032452464,0.037600044,-0.030343479,-0.00864296,0.030274298,0.0311127,0.05330001,-0.0039018313,0.0022085852,0.057694133,-0.004489116,0.091127776,0.113769524,0.13823554,-0.09522096,0.037451975,-0.023504734,-0.11855158,-0.08711501,0.062400874,-0.04326894,-0.045571838,0.06177016,-0.003110737,0.01204566,-0.005286797,-0.05234301,0.08026869,0.025701592,0.016544307,0.005284106,-0.011707115,-0.0040342486,-0.047391716,0.026669307,0.009205672,-0.043978777,0.017669432,-0.0003905134,0.085824326,-0.00014831744,0.046971597,0.06221831,-0.043771867,-0.053097397,-0.03800862,-0.0127760125,-0.03999389,-0.00026346053,0.028423904,-0.016649464,0.08529781,0.07855809,-0.022656256,0.086894944,0.0034855728,0.037159987,0.048401996,-0.02683023,-0.006445301,-0.07678298,0.0723597,0.038173396,0.01469194,-0.06404566,0.010059994,0.013533396,-0.05481135,0.0296327,-0.080194615,0.028781654,0.08748865,-0.056637146,-0.012199155,-0.01588864,0.056632534,-0.061313495,0.064319916,-0.058283806,-3.4571997e-08,-0.010989663,-0.11094588,0.039806813,-0.055186234,0.02277084,0.014193189,0.045017585,0.04899898,0.0343564,0.008375372,0.052864738,0.054637633,0.010501976,-0.011287944,0.089378886,0.04359758,-0.020930985,-0.018373104,-0.036351155,-0.025213068,-0.020851009,-0.020141855,-0.07905849,0.04725165,-0.03621276,-0.08741612,-0.009784169,0.020513188,-0.043001283,-0.0046734195,0.015659422,0.017768621,0.011573609,-0.06435927,-0.12533252,0.036229376,-0.054218713,-0.076449916,0.017571002,-0.047847383,-0.039224196,0.021125084,-0.05984375,0.035109818,0.007936827,-0.051804516,0.041792583,0.034760695,-0.0012361554,-0.02232538,-0.0018776512,-0.07748307,-0.02210876,-0.06926803,0.021873059,0.0471525,0.042933695,-0.0042258217,-0.013640827,-0.036461245,0.0099169845,0.026718134,0.15766959,-0.060872592 +4.2.1.172,The enzyme has been characterized from the bacterium Peptoclostridium difficile. The active form contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.,384,1.0,-0.011512358,-0.046102714,-0.13792643,0.07770615,0.028705446,0.02245799,-0.077043265,0.034185432,0.044170886,0.019003304,0.008441591,0.0018264144,0.048091613,0.07703756,-0.029420368,0.036888976,-0.06002381,-0.039336134,-0.008841462,-0.03641909,0.033069253,0.016537454,-0.0034334026,0.007933671,0.029235456,0.00909209,0.09203266,-0.040783662,-0.0069182804,-0.05566194,0.08845936,-0.062045798,0.13335495,-7.779051e-05,0.06350653,0.08475385,-0.009116907,0.02912286,0.09953286,0.007466445,0.0035990935,-0.02616794,0.0115743475,-0.009697161,0.0061736354,0.022866085,-0.021197604,0.07076304,0.025801469,-0.038968947,-0.037421227,-0.039154936,-0.03081317,-0.015381567,0.023218876,0.03855322,-0.028994298,-0.04122019,0.06598151,0.00045870576,0.080207,-0.020931771,0.01498146,-0.0018645858,-0.08229735,-0.03119558,0.048936576,-0.10371899,0.072104074,-0.053740546,-0.03927024,-0.04783516,0.013237476,-0.014215134,-0.004365813,-0.017432593,0.004372999,-0.011596689,0.042401977,-0.03018846,0.078847565,-0.036793977,0.04318244,0.058381885,0.07702204,0.083449095,0.04957255,-0.06414494,0.0384895,-0.03682166,-0.0025856649,-0.01230951,-0.04064451,-0.10691316,-0.04430586,-0.009618586,-0.010283066,-0.027605504,0.009571881,0.026359946,0.011974084,0.06465805,-0.06855642,-0.095078036,-0.09599744,-0.00092618004,0.0010755179,0.11891738,0.021338904,0.0013856734,0.015862182,0.07101011,0.0144592915,-0.021145836,-0.013270322,0.06867331,0.057168223,-0.071150415,-0.046405204,0.046518285,0.03939016,0.020188052,0.051526815,0.04200148,-0.03200696,0.03941283,-0.07525158,2.4378045e-33,0.054987986,0.08847423,0.032014083,-0.041242193,-0.037365828,-0.023913713,-0.069010474,-0.007272508,-0.022196686,-0.05354194,-0.074087344,-0.056012522,0.04858291,0.025066467,-0.060367215,-0.016993819,-0.027441153,0.015310533,0.032260753,-0.0030285914,-0.050698765,0.047936153,-0.02707953,0.008713556,0.046895646,0.083429664,0.0068735494,-0.015557567,0.09357012,0.019134777,-0.022248479,-0.04433594,-0.14595832,-0.0077925613,-0.015556524,0.020202613,-0.08477818,-0.056273278,0.055703547,0.05828568,0.0006498521,0.018740643,0.024349576,-0.04560393,0.01987889,0.034028213,-0.016322386,0.091521576,0.04635145,0.055344395,0.042811666,-0.06995607,0.13429932,-0.05642068,-0.09609679,0.028269231,-0.009088288,0.00075738895,0.09165875,0.060799606,0.041039266,0.038614873,-0.10878181,0.021180352,-0.00284114,0.0026478593,-0.020481711,-0.012303154,0.017370434,0.10491747,0.02260579,0.023817956,0.055265624,0.049666997,-0.038445774,-0.04353852,-0.033033993,0.023652626,0.040302407,0.015767347,-0.0707679,-0.012206899,-0.028880656,-0.052466724,-0.008801937,-0.028854765,-0.062410463,-0.06218122,-0.06726234,0.011043978,-0.0020972379,-0.06580729,-0.06266988,0.03686048,-0.027117815,-3.2926927e-33,0.076110646,-0.03290285,0.0045748297,-0.011080553,-0.047795203,0.033589784,-0.053308025,-0.030895261,0.0130609535,-0.00017603497,0.07946568,-0.03200135,0.060365707,-0.058220502,0.04078395,0.012414713,0.00809098,0.018659351,-0.0053530475,0.025083259,0.011848088,0.027291464,0.0250956,-0.047605965,0.10089908,0.009805006,0.017000774,0.082940064,0.07875065,0.052180696,-0.005975631,0.011010249,-0.04766666,-0.017895203,-0.06188846,0.10956614,-0.06562691,-0.008466362,0.02054294,-0.075647056,-0.027189119,0.07864267,0.023450939,0.14387704,0.05595,0.06627818,-0.015441329,0.04174785,0.02006502,-0.105410926,-0.01979021,-0.047855645,-0.011399572,-0.0021379886,-0.03225475,0.058043007,-0.014325759,0.010851608,-0.08762611,-0.060123704,-0.06687846,-0.092409626,0.042613965,0.0013287874,0.03221237,0.021935802,-0.006971174,0.028377334,-0.014919958,-0.022223407,0.0133741,-0.031964157,0.00083301537,0.0694106,-0.053787343,0.03924804,-0.075387485,-0.023761272,-0.03263439,-0.013524926,0.02424908,-0.0044354065,-0.041888047,-0.077243805,-0.0023433547,-0.08822864,0.026094485,0.11449538,0.04667749,0.07600128,-0.076399095,0.042672362,-0.009871543,0.04404592,0.019311918,-3.9891212e-08,0.039058052,-0.072979294,0.065673925,-0.08120663,0.046663173,0.051062483,-0.009749153,-0.038851406,-0.031880666,-0.09630427,-0.03544262,0.034310702,-0.036749218,-0.00036860307,0.0056001972,0.052978896,-0.06954023,0.009024591,-0.019532813,0.001072494,-0.05846883,-0.035523873,-0.08261279,0.035383936,0.0069851563,-0.035423916,0.025458725,-0.014469254,-0.073266104,-0.021264816,0.058187027,0.044016194,-0.03706091,-0.00589692,-0.14738472,0.0026673742,-0.060848728,-0.008074149,-0.019134931,0.049785323,0.036710743,-0.0054408326,-0.096071064,0.024106178,-0.08322713,0.020794507,-0.045024946,-0.028793916,-0.03796586,-0.0045971973,-0.0013676311,-0.058850788,-0.038397297,-0.015034544,-0.10134056,0.04497977,-0.038423467,-0.050728127,0.05788634,-0.07166583,-0.0022192795,0.04751505,0.17481628,0.022751994 +4.2.1.173,Isolated from the plant Salvia miltiorrhiza (red sage).,384,0.99999994,0.005038036,0.0027606578,-0.11027324,0.06376913,0.100927815,0.082174815,-0.004131799,0.019106809,0.029613173,-0.03987741,0.0833446,0.01988271,-0.051514134,-0.029724035,-0.00949737,0.018019475,0.007738779,-0.02403793,-0.046837486,0.020558551,0.08425599,0.020625671,-0.0009980407,0.0038157927,0.039477743,-0.017240705,-0.02797322,0.04860025,-0.021369623,-0.10884606,0.06686651,-0.03578425,0.11318007,-0.09767802,0.05734095,0.04561809,0.0041839457,-0.020542853,0.047749072,0.0431883,-0.021383226,-0.06709047,0.022626529,-0.012201669,-0.003791828,-0.02730405,-0.016127603,0.027111214,0.10128416,-0.046705652,-0.04194403,-0.07058039,-0.03562774,0.09263547,0.001935659,-6.658054e-05,-0.00049220654,-0.029347183,0.036546644,0.021850118,0.025682,0.025599582,-0.015151581,-0.0559913,-0.07088819,0.0055924817,-0.025186481,-0.07042528,0.0974046,-0.095295765,0.020416034,-0.052777383,-0.04626446,0.054875746,-0.057456914,-0.005660075,0.010748344,0.022135057,0.043658126,0.02763022,-0.009981577,0.07706328,0.01514911,0.010859089,0.060023367,0.023291254,0.019044818,0.053300925,0.02358664,-0.06254176,-0.043819427,0.036852933,-0.0116937235,0.0029223838,-0.017539483,0.045949657,0.036149696,-0.029664505,0.011020161,0.0404489,0.05632627,-0.012710941,-0.024831345,-0.111350246,-0.059256002,0.08597843,-0.075154744,-0.013466461,0.020323252,-0.07612723,-0.039555658,0.00023450507,-0.042402204,-0.008178548,0.017905775,0.012229317,0.08556174,-0.024921834,-0.07600745,-0.03860981,0.016202984,-0.026614945,0.10972228,-0.018119697,0.03865002,0.0137002645,-0.075567335,1.3521564e-33,0.041590203,-0.06440285,-0.000723239,0.020294484,-0.025335584,0.0091776,0.0025269492,0.06956109,-0.020552896,-0.063655265,-0.04231517,-0.093899034,-0.019217052,-0.033848993,0.005920011,-0.023217335,0.07642397,-0.048459552,0.07309276,-0.016790759,-0.06933054,0.08990834,-0.030023882,-0.056218576,-0.0475496,-0.008749896,0.027005231,-0.07465858,0.107338816,0.013371272,0.059199158,-0.059476085,-0.024238927,0.017942397,0.011952796,0.008323185,-0.113145165,-0.05376326,-0.02437439,0.050938286,-0.0060671805,0.05675775,0.042176645,0.05467781,0.065009564,0.027054165,-0.07088844,-0.039541084,0.12767245,-0.032258026,-0.047979593,0.06321604,0.051675033,0.042905945,-0.055828013,-0.030648764,0.0055797473,0.057037845,-0.017063005,0.014725783,-0.025076292,0.06794533,-0.03623191,0.0072850445,0.039383493,0.015805595,-0.09337498,0.0997954,-0.040765695,0.03203012,0.0013055629,0.02910154,-0.018788345,-0.042000417,-0.045622785,-0.048280437,0.008857143,0.036665317,-0.005165348,-0.060206544,-0.043761965,0.045541346,0.030537479,0.118181214,-0.10282453,0.0040917667,-0.059188865,0.039272767,-0.0072049536,-0.011364887,0.05819952,0.024857465,-0.074934475,-0.049319327,-0.024368847,-2.381261e-34,0.10042447,0.013769101,-0.01388285,0.00062854146,-0.034150906,0.10773123,-0.03193245,0.063396834,-0.058653515,0.03568795,-0.02183758,-0.034128953,0.032611366,-0.07057399,0.04049217,0.092094384,0.03924669,0.13579242,-0.06877215,-0.00074603414,-0.10931103,0.05548638,0.021779722,-0.044205252,0.0020326679,0.018382374,0.04389116,0.009972911,0.006570776,-0.0015399235,0.09063166,-0.020237464,-0.13413717,-0.12764542,-0.06965951,-0.0036120084,-0.06000159,-0.11419608,0.0057217027,0.048216525,0.026169501,0.02688673,0.038371377,0.0052743526,0.08009902,0.05542584,-0.04278468,0.03221999,-0.040505383,0.02921752,0.052491426,-0.061331183,0.006724499,-0.020977627,0.030979645,-0.07326699,-0.0041635963,0.059765585,-0.0006672158,-0.048185244,0.028388886,0.03736096,-0.06706973,0.013902839,0.029817633,0.06688433,0.031448588,0.061321735,-0.07188799,0.05243662,0.07289977,0.03214912,0.022484802,0.09243243,0.02973346,0.08049535,0.012650141,-0.034910135,0.010999297,0.028558815,0.067035064,-0.06730634,0.037287563,-0.09052117,0.0020506242,-0.050415184,0.022919754,-0.014910171,0.0055996915,-0.010409768,0.008965256,0.013585225,-0.05898643,0.036055163,0.13066886,-1.6635502e-08,0.09365642,-0.06934354,-0.06326471,-0.018459631,-0.015971866,-0.030604096,0.017261742,0.03370626,-0.0020883186,0.06705334,-0.023773108,0.00339151,0.03280169,-0.018599927,-0.019226994,-0.016791921,0.10977456,0.05637882,0.01307069,0.03355613,-0.058733515,0.01598522,-0.015553067,-0.0029662105,-0.047480483,-0.09973601,0.093982264,0.0065954416,0.087783195,-0.028627852,0.040732723,0.01619099,-0.00058286905,-0.044363327,-0.015884615,0.08489934,-0.04141662,0.00015667893,0.041870523,-0.025185749,-0.011384888,-0.043018624,0.0077669625,-0.009978932,-0.022072272,-0.05384996,-0.056654606,-0.016928852,-0.05003879,-0.072826274,0.01882767,-0.018662067,0.04825597,0.0040597003,-0.1170565,-0.044321127,0.027538864,-0.03835798,-0.006504742,-0.06721534,-0.021414738,0.00048218176,0.025387205,0.09545295 +4.2.1.174,Isolated from the plant Marrubium vulgare (white horehound). Involved in marrubiin biosynthesis.,384,1.0,-0.046328083,0.05860105,-0.16722271,0.060559485,0.12245154,0.09597308,-0.058940742,-0.007795561,-0.0065189386,-0.059644233,0.049534455,-0.0105980225,0.023329219,-0.10571952,-0.040558547,-0.012269706,-0.081758164,0.018166622,-0.044093918,0.016544875,0.04322602,0.09343966,-0.051523943,0.045633577,0.020253144,-0.03708797,-0.0124403015,0.009320202,-0.0050111637,0.007678104,0.013389033,0.030326068,0.091155626,-0.047791008,0.025082896,-0.008432307,-0.06369035,0.004706423,0.07845968,-0.065799035,0.06629124,-0.013240971,0.08240676,-0.050050132,-0.049373265,0.019976828,-0.0074793813,-0.015972057,0.040729094,-0.030281961,-0.101581864,-0.018654719,-0.011807142,0.07394164,0.00039627095,-0.0062989527,0.0032288083,-0.018034037,0.05423231,0.04614558,-0.011322976,-0.002285275,0.009524781,-0.056435943,-0.056574836,-0.046247125,-0.04007235,-0.03530987,0.09452371,-0.027487759,0.028474957,-0.009455546,0.041416824,0.07365345,-0.0069485777,0.062431205,-0.117536254,0.01883686,0.014506178,-0.0010207021,-0.018034548,-0.018472187,-0.0011358225,0.05490133,-0.0005658757,-0.003057295,0.019384593,0.04653171,0.03702474,0.015312151,0.011907525,0.039713074,-0.002382589,-0.08004788,-0.061558455,-0.024744414,0.027967634,-0.00457358,-0.04372121,0.00829607,0.033792693,-0.011366803,0.034670215,-0.13219194,-0.07924956,0.03270333,-0.047640905,0.01385925,-0.03181721,0.0066658854,-0.017671231,-0.013040796,-0.013060601,-0.097123265,-0.0030496735,-0.004155701,0.0546936,-0.052467663,0.01189926,-0.01411827,-0.004305909,0.040799797,0.17718469,0.0058517386,0.049832586,-0.014008348,-0.08780961,1.2866305e-33,0.033956204,-0.06560435,-0.011512008,-0.0042445892,0.0032701201,-0.053611346,-0.07150228,0.006176505,-0.009368335,-0.05789091,-0.04678489,-0.06292426,-0.014501228,-0.08264398,-0.05321968,-0.03472032,0.0054681157,-0.06820244,0.07531124,0.017952671,-0.013430977,0.06468397,-0.01887189,0.059679937,-0.049274303,-0.017079808,0.04315283,-0.00331226,0.010995601,0.025177598,0.07010552,-0.0841133,-0.034253284,-0.059497815,0.04107877,0.032210205,-0.08830885,-0.061111327,-0.08403758,0.042760145,0.09591399,0.011175966,0.08186816,-0.015183676,0.051918283,0.107183814,0.0099170655,0.08915813,0.08670225,0.011123273,0.0003697587,-0.07774735,0.055744756,0.037772674,-0.09577048,-0.01142892,0.050819352,0.025064418,0.07710481,0.06353713,-0.055569038,0.049996976,-0.047455158,0.043254126,0.023525344,0.03277014,-0.118058935,-0.0149739515,-0.05021655,-0.019174732,0.043894745,-0.056719474,0.0044589266,-0.0028859014,0.020467518,0.000874653,0.012159828,-0.014429669,0.01483226,0.03767517,0.012223585,0.028878724,-0.025339063,0.041400075,-0.07400369,0.0053219604,-0.0512524,0.074064694,-0.08842964,0.036127973,0.041852824,-0.0283061,-0.006318239,0.052988846,0.008801427,-1.9009068e-33,0.017463397,-0.0030430616,0.095243625,0.02918257,0.030040903,0.114189126,-0.01646627,0.0012069643,0.027617076,-0.02525955,0.025068015,-0.043142095,0.10682368,-0.020000117,0.032568872,0.02344172,0.060332444,0.073659666,-0.0027528086,0.033102375,-0.12703843,0.028493792,0.014073197,-0.082743995,0.041145056,0.034717977,0.029310199,0.094359934,-0.040353935,0.062095508,0.0043648216,0.020440355,-0.07907757,-0.04602158,-0.09466386,-0.01936367,-0.04534193,-0.027458683,0.06007859,0.011768558,-0.05024882,0.025254928,0.0047548614,0.079297654,0.07509025,-0.0018782871,0.020068716,0.047678128,-0.056299463,0.083970375,0.03530364,0.008511769,0.011279669,-0.0629825,0.010472979,-0.016626319,0.012558308,0.083025955,-0.011074567,-0.0033409698,0.018994862,-0.0064142947,-0.032542918,0.07044159,0.011788044,0.10195674,-0.05394258,0.011443914,0.00454196,-0.0009184998,0.03328791,0.081318244,0.046412118,0.084506184,0.062428005,0.07482316,-0.064413436,0.007944131,-0.06528764,0.06816174,-0.03461703,-0.04638402,0.02299924,-0.047805216,-0.07284897,-0.047673803,-0.0050847777,0.036036357,0.05676425,-0.008796336,-0.08870996,0.06290147,-0.08903884,0.046365354,0.07599615,-2.1605814e-08,-0.036468253,-0.11462585,0.011270458,-0.035849717,0.0022725288,-0.020634452,-0.012721951,-0.03240799,0.014927481,0.0037785443,-0.057483394,-0.02093951,-0.054736573,0.016198497,-0.0022814814,-0.02380025,0.026147513,0.0070369104,-0.008676739,0.01493646,-0.007423481,-0.05763768,0.020995285,0.01265263,-0.05131289,-0.10510321,0.016415013,-0.0344589,-0.021788195,-0.03326801,0.06322933,0.009262496,-0.10278066,-0.064777404,-0.054270815,0.020639366,-0.046943985,-0.05503291,0.0065131066,0.02372884,-0.010779759,0.031576008,-0.079949945,0.005308488,-0.02588601,-0.0037304747,0.035010427,0.052991033,-0.06852803,-0.12448909,0.035626926,0.029047895,0.014879069,-0.0093360115,-0.034788314,-0.02418023,0.10697136,-0.01695285,-0.013044439,0.009006016,-0.10450242,0.042336732,0.08384038,0.07009339 +4.2.3.157,(+)-Isoafricanol is a sesquiterpene alcohol. Its synthesis has been shown to occur in the bacteria Streptomyces violaceusniger and Streptomyces malaysiensis.,384,0.99999994,0.0035408863,-0.07786074,-0.13604493,0.07222418,-0.04107224,0.05358655,-0.029922577,-0.020502003,0.08706213,-0.046214063,0.06724915,-0.065745346,-0.054030072,-0.0022893269,-0.10299879,-0.03397581,-0.0124653885,-0.006679608,0.09290706,-0.024103655,0.03747403,0.031226017,0.031615842,0.0029834656,0.09487395,0.051250357,-0.035077933,0.03488024,0.038628224,-0.09377955,0.016672086,-0.015997479,0.120026685,-0.119102925,0.06767967,0.0017237839,-0.017096112,-0.047321633,0.12441369,0.034233302,-0.010023679,-0.05078092,0.0074599152,0.05147988,-0.1188545,0.001549725,-0.013142976,0.070269376,0.051765777,-0.019111585,0.0026750332,-0.03469939,-0.116168156,-0.0073060086,0.027789965,-0.051397655,0.075281374,0.00016489344,-0.005664169,-0.012753809,0.07236812,0.020543262,0.035531506,0.0050961124,-0.04439535,0.009733401,-0.0014309568,-0.006617433,0.040876977,0.009672148,-0.06320475,-0.07494524,0.03247008,0.07148023,-0.080197625,0.035657223,0.026762431,-0.02355802,-0.041533735,-0.009202993,0.0395913,0.025240116,-0.0112026455,0.061789263,0.037612017,-0.015672205,-0.06405197,-0.054688863,0.041684274,0.072404526,-0.004338431,0.041675895,-0.012132074,-0.09455094,0.004462801,0.025114745,-0.022220027,0.040999915,-0.045291837,0.010167968,-0.03659595,0.04468172,-0.0644768,-0.07245586,-0.01530937,-0.007114401,-0.055838622,-0.040922876,0.04045136,-0.018535443,-0.031868666,0.009850595,-0.055367067,-0.047048166,-0.015879467,0.01909949,0.080963366,-0.08629184,-0.0038558396,-0.036266163,-0.030120462,-0.038087618,0.0050689485,0.031420562,-0.035163686,-0.042336375,0.021830058,2.6544483e-33,-0.027324222,0.037079297,0.021786138,0.041417446,0.02533496,-0.039811663,-0.052968204,-0.009596973,-0.033694983,-0.0999635,-0.087172456,-0.10336059,-0.028500723,0.07837334,0.03073531,0.013245621,0.008968374,0.020085054,0.053329248,-0.0693439,0.0011927821,0.044833302,-0.012995759,-0.028312324,0.009511472,0.039471023,-0.039307076,-0.014958122,0.03676553,-0.026224839,0.014648756,0.034818992,-0.07511183,-0.045820624,0.055222735,-0.0037888004,0.017164603,-0.02640756,-0.045761462,0.050040774,-0.017909892,0.068612926,-0.0044103344,0.004391566,0.07228299,-0.02456821,-0.09709358,0.0777535,0.11731979,0.049765505,-0.013673715,-0.018973803,0.098569,-0.02138657,-0.062086888,0.05526492,-0.001227372,0.014574832,0.04557155,0.02095568,-0.0027680336,0.058851346,0.023790734,-0.04250195,0.04404691,0.07751625,-0.076748915,-0.056871384,0.042835835,-0.003367986,-0.06996919,0.010608118,0.041967057,0.03349475,0.0130181415,0.023959095,-0.08705272,0.018127235,0.08761002,-0.03616739,-0.082536556,-0.03318072,0.006913257,-0.118288115,-0.009670497,0.026495995,-0.044554938,0.009675104,0.055022098,0.09903014,0.00048301986,-0.047445703,-0.081927575,0.0100402385,0.025155464,-4.9397946e-33,0.07248523,-0.1606021,0.03774085,-0.06432227,-0.07148695,0.051288836,-0.119833246,0.021353772,-0.060544383,0.051890828,0.075485595,0.018347133,0.025034837,-0.0086359205,0.0037588198,-0.040483207,0.03736211,0.089524075,-0.017231114,0.034816727,0.021707583,0.046014536,0.027217014,0.011738352,0.023102922,-0.011151706,0.033535086,-0.014563542,-0.036262274,0.047664694,0.03723758,-0.0067945966,-0.012955991,-0.016608428,-0.02728913,0.05445919,-0.06378187,0.0332232,-0.06178067,-0.029764578,0.018465875,0.06324247,-0.038330257,0.06234044,0.045066036,-0.027032578,-0.15089777,0.00643918,-0.007947164,-0.02794727,0.06860836,0.00912174,-0.05854396,0.020702366,0.017861532,0.0431255,-0.046967514,0.024816385,-0.010814191,-0.050551105,-0.05856893,0.02978422,0.009548556,-0.09290112,0.18296097,0.0005520837,-0.08137143,0.10005706,0.058036443,-0.05170566,0.05816307,-0.0033210374,-0.06319146,0.0020037228,-0.0012729452,-0.06139175,0.0100267,-0.03843246,-0.035043746,0.008284972,-0.028909551,-0.053144168,-0.008138105,0.012635475,-0.06966408,-0.009963804,0.07317569,0.10110907,-0.005339243,0.061788026,0.011232201,0.042702325,-0.064441085,0.022666004,0.037200402,-3.614397e-08,-0.032383356,0.04360261,0.06326077,0.07441256,0.0018748129,-0.035415675,-0.026370734,-0.08235667,-0.0047446936,-0.02696855,0.012194202,0.02514489,0.066624366,-0.027465345,-0.014112316,0.009715345,-0.060464337,0.057538096,0.017150803,0.057059027,-0.056594122,0.013405035,-0.007827411,0.008734589,0.051684245,-0.08442267,0.04925007,0.009900232,0.022720048,-0.0056697293,0.053323608,-0.0074565215,-0.056338485,0.0467999,-0.049542785,-0.022960879,-0.03826574,-0.069263265,-0.061892655,0.00094752095,-0.009897001,-0.050678194,-0.0403022,0.0044436897,-0.028813047,0.07067047,-0.0046884962,0.026846774,-0.06214907,-0.00058583537,0.019834556,-0.010160434,0.00339753,0.005538559,-0.017879097,-0.0057369503,-0.0013767026,0.03089696,-0.05671947,-0.017331641,0.06616264,-0.061183497,0.18854812,0.041874744 +4.2.3.158,"The enzyme, which forms the diterpene (-)-spiroviolene, has been characterized from the bacterium Streptomyces violens.",384,1.0,-0.04346829,-0.065181136,-0.13382103,0.047180016,0.0002432562,0.082432315,-0.08040806,0.09278262,0.08893232,-0.033766262,0.01983845,-0.029097369,-0.0040260484,0.044779748,-0.063037135,-0.02668663,-0.051811054,-0.045789618,0.07907771,0.03883727,0.062744394,0.080022365,-0.025570432,-0.008429461,0.04450228,0.066608414,-0.025933905,0.023624005,-0.021908961,-0.02989192,0.021028172,-0.027183738,0.051050387,-0.0785766,0.08639527,0.061891828,-0.03186819,-0.0021219521,0.11672533,0.023869755,0.0045439964,0.05429288,-0.020283315,0.02086203,-0.04499519,0.012618487,0.003405156,0.07461883,-0.033655144,-0.031898446,-0.017728506,-0.062045228,-0.040064044,0.017702155,0.056332745,0.020601455,0.014681191,-0.06208862,-0.020886585,0.007737787,0.061688177,0.028147902,-0.02056066,-0.033595424,-0.106024496,-0.04307269,0.05043824,-0.061835837,0.035458166,-0.01869327,-0.14926872,-0.064062186,-0.05370122,0.067990854,-0.008387914,0.10521968,-0.011698469,0.009192064,-0.053136174,-0.012062566,0.11304663,-0.0016948273,-0.03203918,0.10445087,0.07859797,-0.018997949,-0.0002782348,-0.025895875,0.09854017,0.04698565,-0.021030514,0.0339886,-0.015500143,-0.0556998,-0.11756066,0.03288859,-0.044944283,0.029358596,-0.00027755584,0.017869575,-0.012455602,-0.03314219,-0.023005104,-0.07564965,-0.025617896,1.8765724e-05,-0.027610917,0.0035582345,0.07345859,-0.030728564,-0.0004037944,0.025810251,-0.0021048952,-0.030343745,0.0040210118,0.017252654,0.022102872,-0.06220321,-0.021189895,0.017842703,0.021474011,-0.015346452,0.025441017,0.022616794,-0.023971165,-0.020679405,-0.069395535,-1.3605481e-33,0.007009902,0.013799077,0.118942834,0.029984884,-0.009349906,-0.005521526,-0.08069578,0.074073255,-0.0070999707,-0.09603996,-0.06469949,-0.11626335,0.0025139784,0.04007227,-0.02266299,0.023990957,-0.03371479,0.032416917,0.055089224,-0.006534847,0.026830086,0.016291697,-0.045280475,-0.013925874,0.09122523,-0.042567104,-0.044173196,-0.023394467,0.10781021,-0.05258479,0.054372072,-0.062249754,-0.06179307,-0.04110453,0.042140085,-0.043183316,-0.023557505,-0.04282535,-0.035926893,0.044487167,0.029654698,0.0028925564,-0.0035734305,0.054004926,0.05530398,0.04005955,-0.051307112,0.05340726,0.039984114,0.051331803,0.021083744,-0.040804252,0.040194906,0.03695859,-0.13595842,0.09844088,0.022250153,0.07124772,0.048353318,0.044671632,0.0024487365,0.11062232,-0.009229726,-0.03874889,0.011176644,0.005417474,-0.052752454,-0.019098401,0.021865338,0.10755044,-0.0880204,0.025544088,0.044255406,-0.038199637,0.024526611,-0.034890488,-0.12065514,0.020882389,0.082445204,-0.020559167,-0.06678632,-0.053310104,0.005166188,-0.08960358,-0.063111365,-0.041201383,-0.008017481,-0.01392791,-4.1616633e-05,0.018316872,0.06125679,-0.07263242,-0.07697921,-0.002777334,-0.007711735,-4.4794155e-34,0.022301013,-0.07252125,0.05583252,0.037769716,-0.017748345,0.10039361,-0.07606575,-0.04663477,-0.036846492,-0.037640035,0.07851645,-0.0110312095,0.027157927,-0.030687785,0.0013973381,0.018601349,-0.011359677,0.0054689944,0.043642662,0.009020371,0.008775163,0.018874936,0.021973735,0.004244697,-0.0059832465,-0.03965623,0.061476648,0.038291812,0.036439147,0.09409995,0.060218956,0.00491317,-0.02297875,-0.0449577,-0.080262944,0.06516741,-0.08832253,-0.0034197674,0.051507343,0.011697407,-0.01703592,0.0071851946,0.00028797807,0.08240584,0.0334495,0.06319804,-0.07735191,-0.0044302284,0.07009398,-0.02050262,0.049149554,0.02337278,-0.012391323,-0.011976263,-0.005241269,-0.018399607,-0.044646718,-0.0059454283,-0.01296799,-0.0029397027,-0.01704964,-0.006926324,-0.061656438,-0.026148854,0.041176915,-0.0015091003,0.009797436,0.058417846,0.059149962,-0.07297691,0.030660285,0.026596269,-0.026255295,0.050014272,-0.03303626,-0.017452486,-0.00037047965,-0.061781272,-0.0037671763,0.064862,-0.023203015,-0.012326968,-0.009340358,-0.07106178,-0.03199295,-0.027450006,0.002154808,0.016796367,0.03649671,0.09103439,-0.020719696,0.06616937,0.007191925,-0.01621724,0.018520027,-2.78329e-08,0.05546084,-0.039277747,0.07739608,0.025074862,0.026565433,-0.06708377,0.020488912,-0.06877053,0.028659135,0.0016548092,-0.015966382,-0.0317445,-0.024499709,0.011474486,0.09578659,0.036712766,-0.06381388,0.0024847991,-0.022469988,0.056495767,-0.03551151,0.0048772753,-0.11228235,0.003827623,0.09932311,-0.08999822,-0.031523205,0.010866302,-0.004094349,0.06049134,0.04333872,-8.4245876e-05,-0.028858015,0.007389714,-0.10413384,-0.02037716,-0.061602194,-0.050597526,-0.032196194,0.044904776,0.045489267,-0.05819889,-0.08567886,-0.000937589,-0.07781617,0.085647546,-0.026761485,0.01771918,0.0018551843,0.008575429,0.04076909,0.039723583,-0.020093646,0.057306092,-0.100869566,0.037823148,0.030419318,-0.011183036,-0.07603844,-0.10376083,-0.045353316,0.0010934843,0.2077597,0.06220276 +4.2.3.159,The synthesis of the diterpene tsukubadiene has been shown to occur in the Actinobacterium Streptomyces tsukubaensis.,384,0.99999994,-0.032345776,-0.08172255,-0.069165975,0.07731713,-0.11807172,0.108402975,-0.023458684,0.05448227,0.07552818,0.070063405,-0.016338943,-0.021477625,-0.012861799,0.0018771274,-0.040735852,-0.05391387,-0.01551647,-0.0056804097,0.06024063,-0.0069507486,0.08200729,0.052031815,0.013284472,-0.06993848,0.0665185,0.029434072,-0.030262817,-0.030407384,0.033318,-0.0590926,0.0051133507,-0.04947518,0.01706559,-0.09188738,0.07599433,0.03437127,-0.06050746,0.03745833,0.15820248,-0.01921689,0.052497663,0.019250875,0.04100159,-0.011138154,-0.054700445,0.059721403,0.016942235,0.0705973,0.049559772,-0.046461888,-0.028369261,-0.07697018,-0.040136606,0.022159757,0.054653827,-0.057197116,0.0034661095,0.009991087,0.008050965,-0.0036776934,0.058433402,0.012768311,0.0714788,-0.09695294,-0.0859096,-0.0372624,-0.021531865,-0.01129261,0.06822624,0.010317436,-0.10204789,0.003416352,-0.013956085,0.019430572,-0.0750443,0.06435001,0.03277376,-0.0005945295,-0.0805349,0.006985578,0.08359552,-0.06615476,0.055712618,0.11624771,0.04654724,-0.02072927,0.025517594,0.00056124263,0.06616722,0.061831046,0.06246791,0.07175668,-0.009557141,-0.05724538,-0.07275624,0.01807056,-0.08970653,0.07866345,0.002884052,-0.031940892,-0.04352859,-0.00021630438,-0.0058396747,-0.051069647,-0.01715648,-0.0029182872,-0.062576026,-0.09937173,0.04485527,-0.043146506,0.0049766614,-0.005765757,-0.027936313,-0.024779474,-0.020697847,-0.09998337,0.024978613,-0.073936924,-0.015548945,-0.0052322582,0.039949458,-0.016656946,0.06229721,0.033008378,-0.008664882,-0.042053577,0.02070551,1.0477804e-33,-0.019187732,0.03887429,0.017945072,0.04089741,0.051043898,-0.043911442,-0.04394217,0.05521532,-0.05248701,-0.064883776,-0.088437535,-0.1088267,-0.024221675,0.021107448,-0.03435425,0.043076806,0.00053420337,0.033697087,0.09276822,-0.025043279,-0.00528014,0.03067918,-0.008559682,-0.034749154,0.011690739,0.044430926,-0.0011347331,-0.016725995,0.074731566,-0.059848737,0.05676873,-0.07491801,-0.08836755,0.014315214,0.046842646,-0.048349086,-0.0465186,0.010798943,-0.009455403,0.011331969,-0.0136618735,0.015411823,-0.055124246,0.07042046,0.017188996,0.039941907,-0.027801305,-0.018922463,0.108646005,0.04650189,0.028062724,-0.024095902,0.08642732,0.017829677,-0.050309386,-0.0038060197,0.023598729,0.06273001,0.1150371,0.066875346,0.028421488,0.012030479,-0.049813095,-0.026314637,0.049245372,0.034017697,-0.005161982,-0.018529743,-0.016268943,-0.00050390867,-0.031061063,-0.02979267,0.068519264,-0.028004864,0.026432587,0.043976318,-0.07980931,0.0012186158,0.047011755,-0.052244212,-0.04832274,-0.044548128,-0.037315723,-0.06940381,-0.060453575,-0.0022547203,-0.05188421,-0.010899798,0.018171351,0.028916707,0.008254933,-0.09721203,-0.14137359,0.06574612,0.02370443,-2.0936844e-33,0.0505158,-0.035907757,-0.047239054,0.03689264,-0.049883217,0.08443882,-0.064444214,-0.03989779,-0.013100511,0.0061019794,0.070139125,-0.01419362,0.0131771155,0.030449001,-0.012638742,-0.0704584,0.08101065,0.10330305,-0.029948425,-0.08006321,0.06279904,0.060102254,-0.009122194,0.017113,-0.010758049,-0.0136975,0.08023191,0.030095054,0.02067671,0.11694209,0.034456346,-0.0046653706,-0.03549108,-0.027765146,-0.10100363,0.07364224,-0.04072225,0.033515885,0.03560039,0.057920486,0.06490693,0.013917622,-0.035917297,0.06631424,0.05727566,0.0015210706,-0.07258042,0.02871449,0.04375253,-0.024281312,0.06962159,-0.029170325,0.010352311,-0.09616466,0.0034343645,0.06723606,-0.026143573,-0.048128,0.03508942,-0.029157983,-0.0039785514,-0.042878956,0.015095277,-0.07462116,0.006281741,0.07821834,-0.0070854775,0.049405385,0.09509587,-0.0015174608,-0.032318633,0.039502274,-0.018148037,0.020527551,-0.00037070632,0.017687086,0.0323156,-0.086912155,0.024416216,0.0019699838,-0.032583177,-0.0036481654,0.019875124,-0.06080817,-0.014349838,0.032876387,0.042236183,0.019987274,-0.008417931,0.0322845,-0.0049149906,0.05839981,0.003998872,0.089352876,-0.020384721,-2.556175e-08,0.06324976,-0.0016728981,0.04614018,0.025201065,0.030418284,-0.08927361,-0.022644935,-0.033417568,0.013360699,-0.0030975717,-0.0016514309,-0.04114584,-0.011903726,0.035926748,0.07986894,0.0520689,-0.10710179,-0.059319418,-0.013668404,0.034798793,-0.03165353,-0.01665077,-0.03232726,-0.030407185,0.04234945,-0.1274449,0.024417758,-0.0459764,-0.023108205,0.023159169,0.06538789,0.037310436,-0.06312956,0.041151904,-0.05698715,-0.059629433,-0.08073193,-0.049968984,-0.0030956303,0.014949974,-0.026368048,0.005955925,-0.036658745,0.03478069,-0.06550762,0.096985,-0.04627771,-0.015354499,-0.035102226,-0.03247676,0.03484657,0.073107235,-0.058711797,0.062268842,-0.10059132,0.054204635,0.019475434,0.01552417,-0.08042229,-0.07593851,-0.06497648,-0.031404473,0.13184331,0.0089853965 +4.2.3.160,"The enzyme has been described from the slime-mould Dictyostelium discoideum. It is specific for (2E,6E)-farnesyl diphosphate. While the major product is the sequiterpene (2S,3R,6S,9S)-(-)-protoillud-7-ene, traces of pentalenene are also formed.",384,1.0,-0.046044506,-0.088385396,-0.050794102,-0.03769551,0.039624337,-0.050118245,-0.04159374,0.085797295,0.05776359,-0.03730592,0.045301527,-0.05979877,-0.08499083,0.018403698,-0.031978842,-0.017092194,-0.03216782,0.022374602,0.035339646,-0.0010675028,0.117371716,0.039226152,0.019228127,-0.010078344,0.070135675,-0.008450715,0.09641531,0.00020138994,0.033630434,-0.13041976,-0.0049355826,-0.008500312,0.015165292,-0.072659805,0.07487783,0.039455,-0.02937087,-0.019257445,0.025259515,0.010462308,0.08108824,0.0051111965,0.005331156,-0.052902415,-0.07455984,-0.035327397,-0.0007255498,0.08089585,0.022120398,0.053338807,-0.0045911525,-0.12841745,-0.010805388,0.048282113,0.00020979521,-0.074208975,-0.025159582,0.009117834,-0.0019274236,0.020963078,0.040507514,0.042469762,0.0041167396,0.006140372,-0.022116793,-0.037631217,-2.4642539e-05,-0.058286384,-0.019554574,-0.099605456,-0.07725318,-0.06555678,-0.0018040993,0.0054516974,-0.0060279393,0.07014013,-0.04528122,0.016690109,0.016311422,-0.052573,0.061534077,0.028114157,0.051073097,0.092386395,0.052051745,0.05315344,0.008185027,0.03702909,0.039713643,-0.041237243,0.052634545,0.04955311,-0.029584883,-0.064142205,-0.09211422,0.09449681,0.010069367,0.083641626,-0.016755644,-0.0006212615,0.050553843,0.019308608,-0.035857882,-0.08828788,-0.034836512,0.018485472,-0.085912794,-0.014394642,0.07800206,-0.030642612,0.0012418666,0.008045441,0.050450608,-0.027701892,-0.027574068,0.023625655,-0.009402871,-0.013140887,0.065215975,0.043901082,-0.00654653,0.009096965,0.0077502485,0.058968812,-0.007159047,0.06704104,-0.08836492,2.2801655e-33,0.003368577,0.05078529,0.01958914,0.03819945,-0.04478138,-0.03557363,-0.045831427,0.055236,-0.111810096,-0.025720868,-0.11639563,-0.08172111,0.05511009,0.008352398,0.019341476,-0.012322326,0.049962886,0.006629061,0.08581211,-0.038200233,0.035923824,0.063592285,-0.07383077,0.032621905,0.050295983,0.018371586,-0.0064485706,0.03337934,0.09916275,-0.032609496,0.03474619,-0.06311572,-0.04298215,-0.02106138,0.03801231,-0.051832598,-0.019506473,-0.07373063,-0.088674486,-0.008519311,0.020995717,-0.004403022,-0.027478836,-0.023205485,0.048215635,-0.076926336,-0.0043830103,0.03890424,0.10044771,-0.0057439976,0.031363484,-0.003624145,0.092641845,-0.006900722,-0.086086035,0.008546676,-0.014828304,-0.018614318,0.09431541,0.03344504,0.0077038384,0.06073185,-0.029379424,0.0007500051,-0.011757514,0.050321966,-0.08957539,-0.05286524,-0.01959584,0.092238896,-0.060612593,-0.0029647588,0.00948807,-0.028019898,0.061308153,-0.05194992,-0.030373374,-0.047269203,0.0045970413,0.008660698,0.038110282,-0.031733837,0.012058101,-0.07229791,-0.100882955,-0.06022684,-0.032010756,0.009331567,-0.011130366,0.05370286,0.058821946,-0.11847981,-0.11695563,0.06252919,-0.011092875,-1.3298241e-33,0.021256804,-0.085159175,0.064258136,-0.031444613,-0.010946295,0.023755176,0.007323912,0.025277892,0.051101483,-0.014565673,0.07680164,-0.014940088,0.058278937,-0.04076826,0.0042879204,0.107520975,0.011861993,0.044252347,0.08028626,-0.03368145,-0.03307903,0.042820252,0.020706298,0.021576025,-0.0095171,0.02013861,0.102988824,-0.009251639,-0.007738814,0.06704395,0.008712817,-0.01815188,0.0020214622,0.043511372,-0.108290255,-0.00075625733,-0.039805517,-0.046550553,0.034666773,0.015712036,-0.06380356,0.0062209396,0.016183112,0.08015155,0.03983925,0.015921844,-0.07713621,0.06147947,0.014984969,-0.040749535,0.022126392,0.00092312385,0.007537091,0.02871414,0.010892228,0.008564267,-0.004945176,-0.043716628,-0.023334246,0.0057737497,0.015875079,-0.041899852,-0.011715639,0.017561536,0.10926445,0.06919672,-0.11663701,0.06690397,-0.010303865,-0.015492515,0.047310222,0.04127218,-0.02297485,0.04276717,-0.018829474,-0.011289023,0.026363714,-0.039365914,0.020868566,-0.00091618724,-0.027952768,-0.030800683,-0.006475841,-0.038599547,-0.02406596,-0.05640548,0.044041228,0.119390845,0.01270521,0.03341849,-0.0091651995,-0.015428355,0.02722193,0.0828718,0.13243322,-4.277556e-08,0.055615567,-0.09438468,0.04001041,-0.06514396,-0.01051677,-0.038797513,0.077231325,-0.009323096,0.022338571,0.033720322,-0.050490703,0.029836798,-0.014262838,0.011730988,0.119814515,0.04871445,0.03905993,0.05717608,-0.03938932,-0.0070228474,0.09217717,-0.012766415,-0.07259536,0.004603388,0.031394966,-0.056207392,0.005112702,0.05057571,-0.04359167,-0.017605059,-0.03314628,-0.020463327,-0.024713961,-0.07427178,-0.07628184,0.097053915,-0.043887563,-0.017335324,-0.06144275,0.067878544,0.047529943,-0.092957556,-0.044882018,-0.031115234,-0.08239905,0.0017765439,0.01492682,0.00039676114,0.015237915,0.0013821367,0.018469023,-0.024905426,-0.02421078,-0.0052680904,-0.07396656,-0.064544916,-0.016172558,-0.009475877,-0.033363458,-0.088190086,0.0026930333,0.047924656,0.21437018,0.035997804 +4.2.3.161,"The sequiterpene (3S)-(+)-asterisca-2(9),6-diene has been shown to be synthezised in the slime-mould Dictyostelium discoideum. The enzyme is specific for (2E,6E)-farnesyl diphosphate.",384,1.0,-0.057314955,-0.0857563,-0.10900807,-0.009975026,-0.006887937,-0.023778055,-0.050953154,0.03972856,0.08256634,-0.018811798,0.028948823,-0.07703831,-0.017443798,-0.070339575,-0.034618203,-0.051095426,-0.039296124,0.036237497,0.0063992315,0.047151215,0.07646802,0.04025809,0.0274303,0.01601497,0.10401974,-0.035481293,0.06667082,-0.025505219,0.02846651,-0.12847634,0.006517465,0.010261015,0.006493154,-0.0717011,0.069409594,0.005091944,-0.008308195,0.00051918667,0.044921488,0.010805915,0.063980855,0.031211223,0.020686664,-0.039583065,-0.08232062,-0.01299262,-0.028485842,0.046297636,0.04497764,0.020049311,-0.016018843,-0.10134593,-0.06131167,0.033844844,-0.050040923,-0.064326234,-0.049539275,0.034925513,-0.003712364,0.025709162,0.038746864,0.02788891,0.05919294,0.0046105674,-0.0068964,-0.028010108,-0.05668929,-0.047965776,-0.020058107,-0.06521509,-0.104751006,-0.082296945,0.0086560445,0.03257814,0.0046344986,0.09776817,-0.024828786,0.02513435,-0.014320041,-0.032557912,0.061487757,0.005414734,0.079361394,0.11842314,0.026431285,0.05463891,-0.027715469,0.028899442,0.040998895,-0.05549587,0.059891336,0.07934993,-0.039038766,-0.04485411,-0.04899282,0.110197216,0.04511268,0.09783753,0.003914967,-0.0012217843,0.048571575,0.024243822,-0.045611173,-0.016827775,-0.025271747,0.0042458037,-0.084652215,-0.012603216,0.04618065,-0.050486688,0.007609035,-0.018114163,0.018208692,-0.060310483,-0.057519235,0.044978775,0.012279351,-0.07440136,0.058966402,-0.035713393,0.0039639776,-0.002001638,-0.01479588,0.04813914,-0.002349736,0.039165515,-0.07481963,1.9432523e-33,-0.0044303946,0.06690674,0.062174983,0.063580364,-0.061646793,-0.050706953,-0.009032631,0.047327667,-0.112032846,-0.06278738,-0.08721378,-0.09670077,0.043269005,0.040286668,0.023855673,-0.04103812,0.07448365,-0.019344952,0.045949847,-0.07535424,0.02029102,0.017539164,-0.044716336,0.010953585,0.07208663,0.024551323,0.004628172,0.009259168,0.108745955,-0.04732846,0.022139287,-0.038622983,-0.030294444,0.01340442,0.020707296,-0.029016005,-0.047658414,-0.018909516,-0.11141716,-0.011699401,0.022634756,0.0063303313,-0.035979137,-0.06323621,0.04206415,-0.029036267,0.05438798,0.015727457,0.12098043,-0.040097795,0.02658498,0.017399859,0.08698333,0.021308986,-0.058058724,0.032161012,-0.01959648,-0.009858963,0.08817531,0.05435773,-0.003210451,0.044497956,-0.04985123,0.03225986,0.017934792,0.086582884,-0.122783855,-0.03806929,0.00028365786,0.07458014,-0.0684717,-0.010317042,-0.017745158,-0.05218943,0.025435813,0.010225726,-0.066789255,-0.011010297,0.03238755,-0.021442175,0.10630095,-0.025965529,-0.009384506,-0.03477056,-0.06370133,-0.058781434,0.008100262,0.033205144,0.019148072,0.090622574,0.057617202,-0.13435973,-0.08040145,0.024231523,-0.02615006,-2.1248526e-33,0.01989085,-0.09787921,0.026014205,-0.0004585775,-0.0041873227,0.035941806,-0.00811551,-0.0032966358,0.06520215,-0.0033117593,0.08230056,0.019744584,0.08881781,-0.05820461,-0.010363314,0.039155867,0.019061983,0.045976948,0.067712,-0.023037292,0.017209891,0.06623698,-0.0027385156,0.016903583,-0.029821616,0.008185665,0.07844036,0.0018838238,-0.011888423,0.066369526,0.00385639,-0.017182587,0.0057352963,0.024903478,-0.083573855,-0.018555978,-0.051074613,0.0017078458,0.008490777,0.013138433,-0.08957624,0.00844249,0.0067320047,0.09886738,0.10778109,-0.007558211,-0.10360427,0.071205206,0.0345095,0.0010371817,0.039536826,-0.04829251,-0.013119454,0.030462055,0.043499522,-0.0006059565,-0.0063064834,-0.039959993,0.011206419,-0.02686275,-0.025192093,-0.040532287,-0.015444767,-0.05760418,0.095146045,0.055904817,-0.14313442,0.03506784,0.016643899,0.012615441,0.05573883,0.0370244,-0.04447831,-0.00072959764,0.012516883,-0.06319259,0.020528352,0.0028968256,0.03343201,0.03962701,-0.071702495,-0.033253193,0.041157424,-0.0195898,-0.024835473,-0.043418396,0.03996515,0.114694074,0.021312438,0.029317547,-0.030636085,-0.033340912,0.05731733,0.102159165,0.11340591,-3.7631363e-08,0.05279961,-0.040295947,0.0071000657,-0.030563407,-0.025520151,-0.049044356,0.07930484,-0.044071954,0.024170011,0.0023098208,-0.04683338,-0.004099701,0.04258253,-0.016236244,0.09067195,0.011923395,0.031738084,0.06956946,-0.0139028365,0.008033953,0.09175331,-0.00444666,-0.027413936,0.026803857,0.09275302,-0.07935339,-0.012677129,-0.05166201,-0.02766242,0.009619436,-0.024813717,-0.006162852,0.0018533508,-0.046662234,-0.08825178,0.026186142,-0.027026854,-0.010701356,-0.009750083,0.059320282,0.022279328,-0.071175426,-0.04558031,-0.013769768,-0.08698871,-0.0033758364,0.009769155,-0.00065719505,-0.02290104,-0.021718673,-0.016743453,-0.035830077,-0.024218734,-0.008294503,-0.019259911,-0.06618327,-0.036508225,0.02366728,-0.06704855,-0.07664378,-0.040115748,0.002104077,0.19875637,0.03243745 +4.2.3.162,"The enzyme, found in the bacterium Streptomyces viridochromogenes, is specific for (2E,6E)-farnesyl diphosphate and produces only (-)-alpha-amorphene.",384,1.0,-0.03438382,-0.063201144,-0.09550244,-0.010114094,0.064643115,0.02566194,-0.025536114,0.07121592,0.097249724,-0.021075144,-0.034139287,-0.053954795,-0.07880353,0.045985255,-0.016351283,-0.039631065,-0.07169925,-0.024514187,0.093278,0.017690303,0.08521699,0.023428049,0.046043485,-0.040371984,0.046159554,0.038831223,0.030010844,-0.0020286222,-0.012939528,-0.048750952,0.057529364,-0.017594103,0.06402919,-0.028906532,0.093905054,0.1141383,-0.030720647,-0.06990041,-0.026065791,0.02123899,0.015909728,-0.016723946,0.026643392,0.03983597,-0.039056003,0.01531246,0.013150916,0.09926166,0.033572044,-0.021023327,-0.032035522,-0.107150346,-0.07591068,0.008851847,0.027425997,0.036845412,-0.005711838,0.013306597,0.0023150614,0.03629994,0.10969122,0.01583231,0.053396977,-0.0256953,-0.026807686,-0.038825557,0.085064754,-0.07606975,0.04450669,-0.06306736,-0.09305924,-0.03216063,0.0043320856,0.025441322,-0.020287884,0.020915095,-0.018543143,-0.027171778,0.04324852,-0.0814775,0.023832798,-0.11112488,-0.0089761885,0.09633601,0.038271364,0.015629893,0.0109653985,-0.0023530421,0.08933369,0.0478981,0.03885582,0.015762236,-0.031278264,-0.09374109,-0.055841923,0.010976273,-0.032572582,0.06424631,0.024009155,0.010318561,0.0026568507,0.009773371,-0.027707804,-0.0034333947,-0.040552698,-0.01859281,-0.045521647,0.063758515,0.018058114,-0.03281307,0.0043097185,0.0758363,0.08851275,-0.021927277,-0.010917968,0.021072904,0.040185142,-0.057178956,-0.048087895,0.0595767,-0.053618554,0.021975022,0.05320587,0.07309573,-0.048265267,0.013495966,-0.10620952,1.3350465e-33,0.031781092,0.11756431,0.07686908,-0.07103979,-0.095502816,0.03523342,-0.08436481,0.028453197,-0.07568137,-0.045132626,-0.05181393,-0.09179504,0.0805322,0.015821842,0.0916808,-0.0200752,0.026579838,0.036595322,0.07712481,-0.07031116,0.009671417,0.019186508,-0.019318603,-0.0040323194,0.013686974,0.00011886653,0.00094182196,0.02852618,0.08068674,-0.029319061,0.054376338,-0.03365373,-0.04174309,-0.016130745,0.055406433,-0.08163621,-0.11280545,-0.071725264,0.014765641,-0.029807819,0.025088977,0.014283515,0.046838988,0.034478042,0.04674751,-0.07810164,-0.040018387,0.063262716,0.089550406,0.005517924,-0.008157849,-0.041588183,0.0773987,-0.03556557,-0.09510794,0.057932395,-0.01667483,0.056016162,0.05027261,0.01738783,0.049749367,0.055106685,-0.00040516444,-0.003752194,0.00080211175,0.005952294,0.00450736,-0.03909739,-0.020407084,0.094546966,-0.012832103,-0.008935049,0.036915857,-0.020739362,0.031581175,-0.02947896,-0.077081054,-0.011225966,0.07483582,-0.0630877,-0.028643958,-0.06407635,0.023143396,-0.046460338,-0.096919194,0.005347766,-0.024860635,-0.03095352,0.029881429,0.12887451,0.031068873,-0.1594009,-0.13298641,-0.0036823747,-0.027840992,-1.6741139e-33,0.07270965,-0.07197288,-0.0105034895,-0.077570915,-0.009566535,0.055192646,0.03819765,-0.03879572,-0.018186383,-0.04772108,0.090301104,-0.0006782407,0.018813267,-0.10389491,0.019842586,-0.009568154,0.04101535,0.03255708,0.095005415,0.026493665,0.007010852,0.024271285,0.0358606,0.06517962,0.028363153,-0.013057629,0.05610553,0.043959368,-0.004064722,0.055435278,0.024114363,0.02742529,-0.00085456466,-0.035769176,-0.055138957,0.004585414,-0.018446635,-0.026009157,0.06699152,0.0014154819,0.015431608,0.034605414,-0.016932929,0.057408348,0.040721636,0.0715296,-0.024005039,0.063936785,0.0020022257,-0.05457491,-0.025986543,-0.036608152,-0.019272149,-0.033196293,-0.033733528,0.0011905608,-0.060085922,-0.011695307,-0.03570488,-0.020416936,-0.0334314,-0.028863441,0.028192054,-0.032924637,0.0554974,0.059052505,-0.028709518,0.079444826,0.075555325,-0.07230856,0.060559064,0.008630448,-0.025525993,0.018055664,-0.08765139,-0.034010112,0.025547996,-0.011940203,0.026074883,-0.08481978,-0.0018450744,0.04333962,0.004063166,-0.009501242,-0.019525379,-0.06588258,0.056186102,0.040231545,0.00795209,0.052344568,-0.07439468,0.012357314,-0.0021307366,0.003629729,0.07554819,-3.3447886e-08,0.06490662,-0.023907736,0.12590481,-0.036001936,0.060641423,-0.056496017,0.05400038,0.006771348,0.009450164,-0.014093672,-0.058467094,-0.0042132903,0.050656497,-0.07517275,0.070886716,-0.0036119763,-0.07577052,0.020571306,-0.06770658,-0.005453778,0.02909184,-0.009059733,-0.07307774,0.03674611,0.023482712,-0.005853271,-0.043437634,-0.039646674,-0.017091807,-0.008472116,0.053756885,-0.020394513,-0.00049789157,0.0115842465,-0.05394101,0.032746226,-0.052420374,-0.062417556,-0.05596918,0.02749368,0.01153033,-0.011619015,-0.052429084,0.014760201,-0.039378636,0.03648249,-0.008385625,-0.028471759,0.015003995,-0.009652835,0.05749901,0.022003813,-0.08701871,0.019346902,-0.08386798,-0.06745866,-0.010606861,-0.05066795,-0.0013631891,-0.03716876,0.077070005,-0.04803357,0.189757,-0.057277266 +4.2.3.163,"The enzyme, which forms the sesquiterpene (+)-corvol ether B, has been reported from the bacterium Kitasatospora setae.",384,1.0,-0.03678565,-0.008753219,-0.11074306,0.03062613,-0.039687105,0.03993581,-0.09213025,0.06655183,0.066394046,0.0059205326,0.04961724,-0.13380703,-0.01731531,-0.025372375,-0.047547318,-0.06301012,-0.044579744,-0.0856173,0.035264593,-0.039657388,0.03890315,0.059438962,0.0061973617,0.014698127,0.064347476,0.060126502,0.0014630695,-0.02405684,0.03807753,-0.12068221,0.0017412638,0.039047822,0.033611618,-0.12240801,0.09059087,0.024490625,-0.008185,-0.038121894,0.11706532,0.026603242,0.029456206,0.0007162785,0.05654307,-0.06397123,-0.07982553,0.054259554,0.0572475,0.02368502,0.06166256,-0.0036828609,0.02452328,-0.032597546,-0.06760223,0.042310465,-0.034487676,-0.03967302,0.012068069,-0.058137197,-0.01040263,0.037758864,-0.0017251691,0.044709764,0.03944023,0.029532516,-0.03271889,0.0005389565,0.014141115,-0.045727,0.042057034,-0.038122784,-0.05323668,-0.09289537,-0.034118485,0.07473747,-0.03674301,0.055262487,0.055797406,-0.002448662,-0.012085981,-0.029438533,0.025996499,0.019817885,0.03732268,0.090685815,0.011549878,0.03866002,-0.027680863,-0.10192368,0.1093044,0.06796033,0.041692417,-0.018428715,0.020346582,-0.057990618,-0.039323553,0.035823755,0.029563526,0.07404896,-0.018578848,-0.042026836,-0.005896528,0.01618085,-0.06983558,-0.05986025,-0.051368743,0.01064344,0.04840704,-0.012935176,0.15728064,-0.020031165,0.053931225,-0.014678835,0.027907476,-0.048817016,-0.02483311,0.05491411,0.09229314,-0.04583744,-0.015008835,-0.006516173,0.05121159,-0.09604133,0.041623674,-0.02226372,-0.018777277,-0.009075297,-0.055959042,-4.3789405e-34,0.036207452,-0.028808538,0.03417464,0.0119363675,0.03878009,-0.01582535,-0.04664656,0.08606616,-0.095955774,-0.1260399,-0.13169841,-0.07910913,-0.04044924,0.08258436,-0.09681476,0.051690307,0.024392234,-0.058345772,0.019039223,-0.045993384,0.050763454,-0.0030175066,-0.012086786,-0.001054737,0.06045713,0.03824388,0.024594612,0.022624074,0.057523374,-0.018762844,0.01616926,-0.039865,-0.044032726,-0.007345747,0.029427772,0.0151386345,0.010670322,0.029110184,-0.095376275,0.03684414,-0.0027885651,0.07912458,-0.046792336,-0.031030895,0.051962364,-0.035287593,-0.05400232,0.04631185,0.0634646,0.029698437,0.011432424,-0.026117217,0.048005924,0.07880587,-0.040848512,0.059882015,-0.064682774,-0.018261366,0.01232901,0.04984641,0.0804045,0.10397023,-0.01952374,-0.005834657,-0.02050511,0.06335547,-0.025804669,-0.031071901,-0.026165908,0.045507163,-0.06078711,0.012450364,-0.014580773,0.018301232,0.059701726,-0.008203472,-0.09636481,0.0029526388,0.03622908,-0.009606534,0.023969369,-0.09826213,0.08907417,-0.02454525,-0.07622058,-0.023243845,0.0054032626,0.030119102,0.005711117,0.0034316941,0.07030389,-0.06451347,-0.02188867,0.0033978971,-0.09434565,-1.3067558e-33,0.0022401938,-0.09446569,0.01680802,-0.02673049,-0.061741434,0.049894415,-0.0064286287,-0.041208148,-0.0065283854,0.06172582,0.07764081,0.030104103,0.025524879,-0.07343273,0.016838292,-0.05376171,-0.020982606,0.073618926,0.02000641,0.013146887,-0.0051263752,0.037749384,0.02014806,-0.038452245,-0.002651697,-0.021029878,0.043981884,0.01010061,-0.070202745,0.021101173,-0.012813338,0.000801922,-0.0076662134,-0.01162174,-0.10762469,0.011354217,-0.055124447,-0.03996782,0.010913066,-0.023489408,-0.023066863,0.046513546,-0.010368969,0.051864583,0.08881098,-0.02953343,-0.13066441,0.018637747,0.05110176,0.0058926833,0.063571505,-0.027651878,-0.008328942,-0.0211438,0.0025399725,0.02940571,-0.016818337,0.010581791,0.03857368,-0.026846625,-0.022425704,-0.037702255,-0.016399145,-0.008968274,0.12646195,0.047606632,-0.008078969,0.054060802,0.0413982,-0.050754268,0.076085515,0.007527419,-0.029010944,0.0019020867,-0.032252047,-0.02372194,-0.008900513,-0.11174748,0.009218687,-0.032892376,-0.10086087,-0.07964634,0.042332955,-0.08256061,-0.04740348,-0.032940615,0.03115595,0.0808019,0.0001661897,0.108099006,-0.042341895,-0.012010285,-0.019077403,0.06924352,0.107670896,-3.110411e-08,0.018180437,0.0061692307,-0.010499063,0.07724158,0.025916958,0.011804674,0.024243157,-0.03786801,0.048969336,0.0063928775,-0.021092402,0.06296336,0.013182028,0.012025522,0.06800587,-0.0012358931,-0.03679831,0.012098721,-0.045823783,0.0062959543,0.060917765,0.014538316,-0.03800225,0.023102121,0.040496405,-0.120725475,0.003984876,0.08881091,-0.012215174,-0.032607913,-0.069947824,0.025866836,0.03318845,-0.03682307,-0.07442065,-0.041354094,-0.0539486,0.007953774,-0.038680453,0.10841908,-0.0021535817,-0.10869728,-0.04955089,-0.032866668,-0.009048904,0.071666144,0.021004464,0.0065281847,-0.027094372,0.0065497854,0.07798749,-0.015684731,0.06224893,0.049130846,-0.06997336,-0.010830678,-0.07106708,-0.00045867343,-0.014264424,-0.07078237,0.015133685,-0.02885641,0.10751411,0.05659631 +4.2.3.164,The enzyme has been identified in the myxobacterium Sorangium cellulosum and in the fungus Fusarium fujikuroi.,384,1.0,-0.011435227,-0.0051836963,-0.121657655,0.004368179,0.06490877,-0.0020009729,-0.032944355,0.08162015,0.018189585,-0.03926239,0.09983669,-0.09813954,0.0016608286,-0.008300974,-0.08163219,0.015728403,0.06425428,0.03919548,0.011323512,-0.014864957,0.07648818,0.03750543,0.06316952,-0.02542545,0.059082147,0.033797603,0.018632738,-0.007431765,-0.037746094,-0.07524701,-0.013657442,0.07056496,0.12988016,-0.020604739,0.07931643,0.1260366,-0.05632461,-0.08292601,0.085668996,-0.041332267,0.03931097,-0.021669168,0.06139589,-0.03715092,-0.05214736,0.0017921687,-0.018957384,-0.0015594127,0.060114488,-0.008228952,-0.084742285,-0.055740714,0.003739021,0.036469672,0.0435576,0.024308441,0.04239855,-0.031274606,-0.039604075,0.0398166,0.0041264547,0.002400605,0.060393944,0.004606356,-0.022638688,-0.016872214,-0.08640875,-0.029977037,-0.025381383,-0.030592613,-0.06396847,0.036979858,0.010797658,0.06301783,-0.016586602,0.0316105,-0.024227524,-0.01983446,0.06360575,0.0076872865,-0.03387127,0.018388644,0.042787895,-0.00986778,0.012061141,0.018074172,0.056209926,0.030616295,0.0195695,0.057624754,0.09964725,0.029388398,-0.028834287,-0.006715979,-0.047836866,-0.016505403,0.088059336,0.045222692,0.007401176,-0.08705201,0.011570092,-0.08198816,0.028842693,-0.081752196,-0.07180787,-0.03804234,-0.049275298,0.0013551479,0.090274796,0.006092125,-0.07629373,-0.042265706,-0.014640389,-0.08335552,0.019358406,0.057475913,0.13748424,0.004502748,-0.1228456,-0.072918534,0.03399803,-0.019657651,0.031960823,0.03651733,-0.022010546,0.028380247,-0.12062223,1.6465515e-33,-0.005446127,0.014952319,-0.05624697,-0.006943531,-0.0073116133,-0.09892792,0.010313315,-0.012603973,-0.049656104,0.016284306,-0.06470639,-0.0039313035,-0.03834723,0.012168198,-0.04008601,0.035372403,-0.013743931,-0.05997438,0.049835507,0.011525673,0.058106825,-0.05410879,0.0034970688,0.0270411,0.040145505,0.025845377,0.039990064,-0.08001041,0.083895646,-0.019254616,0.03398383,-0.07271177,-0.18482746,-0.041287784,0.06611601,0.034717176,-0.020768762,-0.04398867,-0.06687157,-0.019013617,-0.028145459,0.04392308,0.011530822,-0.0738345,0.071249776,-0.034208708,-0.036772277,0.11595608,0.13130169,0.050777897,0.05071944,0.005445726,0.10968691,0.014578278,-0.034695696,0.031939518,-0.00027318893,0.057956103,-0.025109809,0.062752485,-0.016839774,0.03239888,-0.033141762,0.10750695,-0.06866026,0.021627927,-0.041406013,0.010821649,0.014148694,0.06744658,-0.026291277,-0.052411422,-0.039667163,0.008772442,-0.018681528,-0.026002036,-0.13042894,-0.09178512,-0.015011336,-0.05660175,0.029383799,0.0138394125,-0.00894801,-0.061953217,-0.05324997,0.05195118,-0.066045485,0.025634307,-0.055829834,0.0035156058,0.08601483,-0.08336586,-0.045983974,0.052534245,-0.013201546,-3.3857782e-33,0.029075814,-0.08346111,0.05507104,-0.02324449,0.014427001,0.032686166,0.008243385,0.056236435,0.03839341,0.0060536666,0.020575423,0.00048106973,-0.034955654,-0.012660119,0.026177578,0.06904133,0.00416377,0.11848881,0.0018789661,-0.05724834,-0.034979407,0.06289067,0.05836787,-0.066228636,-0.023108099,0.05153243,0.07129229,0.054939277,-0.008633112,-0.0036478385,-0.01818643,0.017096449,-0.03904587,-0.066561766,-0.016720686,-0.045676336,-0.030820394,-0.07536005,0.08849288,0.006559922,-0.060928747,0.039828353,0.020231623,0.07001942,0.001137704,0.023798523,-0.10826882,0.049631447,0.055422936,0.029933512,-0.03236991,-0.008478084,-0.016185364,-0.015303199,-0.025064966,0.024593739,0.013649692,-0.0040254393,-0.08170118,-0.039986975,-0.039457075,-0.02227198,0.010028806,0.053175278,0.09275982,0.081232876,0.001586016,-0.005872733,0.027418125,-0.041223478,0.08978082,0.036101528,-0.09325942,0.0436235,0.017945716,0.020289164,-0.017201062,0.07951793,0.022329947,0.019229762,0.04444148,0.022748768,0.07608783,-0.05663826,0.022466099,-0.09737536,0.03325734,0.082846366,-0.06448376,0.028830834,-0.008653026,0.014773701,-0.05928903,-0.0065028416,0.045297377,-2.6732419e-08,-0.025581991,-0.041905813,0.037398677,-0.12718166,0.06583641,0.013070848,-0.045099907,0.025530012,0.021619424,-0.0031777427,0.0083063925,0.07963625,-0.0057768747,0.031605605,0.001954122,-0.0625903,-0.033149805,-0.019818477,-0.023167487,-0.026747035,0.0016641081,-0.013646282,-0.06571585,0.045451827,0.025759293,-0.025471179,-0.028099759,0.03172848,0.027728723,0.061678316,-0.018601842,0.012144151,0.0009108518,-0.065564156,-0.13426787,0.054379616,-0.04556602,-0.042306595,-0.014848444,-0.0069054514,0.011932235,-0.100539885,-0.011184967,-0.020687317,-0.032683924,0.012827244,-0.040530607,-0.020379653,0.027640607,0.0162617,-0.0058539663,-0.011385753,-0.024730261,0.004643563,-0.06354212,0.029593319,0.024081519,0.021839773,0.0030276862,-0.05498849,0.00285183,-0.04160267,0.12518622,-0.0004509585 +4.2.3.165,"The original enzyme (STC5) from the fungus Fusarium fujikuroi is inactive because of a critically naturally occuring mutation that leads to an asparagine to lysine exchange in the NSE (Asn-Ser-Glu) triad, a highly conserved motif of type I terpene cyclases. Sequence correction by site-directed mutagenesis (K288N) restores activity.",384,0.99999994,-0.044105694,-0.062530965,-0.09160402,0.05909766,0.07873789,-0.040823236,-0.09592153,0.033575665,0.075085245,-0.06215781,0.10579721,0.009501118,0.010684844,0.012546399,-0.083824165,-0.015613657,-0.034081068,0.013290078,-0.0097071305,-0.09491393,0.026146218,0.113139115,0.023590164,-0.032566536,-0.014494194,-0.053692427,-0.0033862775,0.03417983,-0.014035665,-0.11094253,-0.06945283,0.027311316,0.011088652,-0.046040073,0.012029173,0.099301524,-0.06809916,-0.020735508,0.07436974,-0.066716835,0.02768808,-0.06692347,-0.01680972,-0.035640344,-0.0543479,0.0155634135,-0.022272723,0.007567479,0.06157792,-0.027182909,0.024393307,-0.06966957,-0.0065808184,0.014658047,-0.016597241,-0.008101767,0.021846706,-0.04651807,0.009300521,0.010988346,0.043258797,0.05054308,-0.02095149,-0.042217486,-0.0036906628,-0.034879923,0.015537581,-0.010881764,0.05042211,0.00074997195,-0.045641117,-0.020402234,0.0005241182,0.024004554,0.00071028667,0.1181143,-0.037533823,0.013676736,-0.03705174,0.0029630214,0.058357064,-0.0050143236,0.13237399,0.031952307,0.07350316,-0.035697825,-0.019330973,0.037483472,0.07165925,0.066196404,0.0786831,0.06576265,-0.00127587,0.008800654,-0.041733652,0.038019862,0.0584262,0.111262865,-0.07259251,-0.017447714,0.013403736,-0.029333092,-0.03421571,0.006981798,-0.0018418593,-0.026176615,0.00584804,0.00031489626,0.04940042,-0.13422902,-0.06397839,-0.006970461,0.020930788,-0.08749753,-0.020611307,0.004788744,0.029937558,-0.011776525,-0.07719691,-0.05456416,0.045205027,0.07590331,-0.012043369,0.03331079,-0.03656238,0.028877094,-0.09748832,2.0770285e-33,-0.0044600093,0.115414366,0.048651166,-0.0022889383,-0.019820334,-0.08996243,-0.0337586,0.018369865,-0.025715636,-0.05571271,-0.06869793,-0.02466449,-0.048084393,-0.09661426,-0.02261637,0.023772411,0.047346007,-0.025782812,0.04587909,0.00097264984,0.07660749,-6.724369e-05,-0.056480654,-0.010238183,0.023663642,0.09429003,0.03135683,0.013774871,0.09578958,-0.019214813,-0.04887047,-0.06384043,-0.09035332,-0.0456946,0.10018845,-0.006158772,0.035408154,-0.03453825,-0.025495034,0.015257082,-0.01253983,0.059846196,-0.03693043,-0.039336346,0.038879875,-0.016675645,-0.057497397,0.09298144,-0.010028716,0.046857607,0.04024663,-0.00765798,0.07647208,0.0479361,-0.02577246,-0.0272572,0.012753156,-0.0005453226,-0.043060876,0.08461777,0.08313574,-0.015314956,-0.082609326,0.07472225,-0.047766156,0.08562755,-0.07149886,-0.046484586,-0.030149875,0.08611345,-0.048171517,-0.032596473,-0.0015373061,0.022110924,0.027984843,-0.034662236,-0.13249142,-0.07858059,0.018109133,0.015969295,0.00598669,-0.013022857,-0.08879127,-0.03345156,-0.02642475,-0.03464289,-0.0064211213,-0.01939049,-0.024165966,0.00024747662,0.062555395,-0.11508452,0.017573738,0.063583136,0.029470207,-4.0227764e-33,0.03859262,-0.06668451,0.040431898,-0.025669396,-0.086280696,0.0769754,-0.027165523,-0.024635956,-0.0025077064,-0.028914195,0.042087685,0.020903485,0.01772124,0.049944706,-0.026735649,0.024906777,-0.011536475,0.12000502,-0.037046045,-0.039401837,0.046769675,0.05648996,0.011071634,0.037635766,0.010241925,0.030020233,0.027919488,0.082796425,0.012052367,0.0786488,-0.050074648,0.004507664,-0.0050713397,-0.0137102995,-0.009898253,0.037131783,0.004361751,-0.020878058,0.045359176,0.055395547,0.004788424,0.06299635,0.018250762,0.11664002,0.03359078,0.10749751,-0.12951517,0.12341943,0.09789942,-0.06908761,0.08118931,0.017171375,-0.049997427,-0.039096184,-0.014598597,-0.016609227,0.07140978,-0.00039291248,-0.058587175,-0.021138795,-0.059891786,-0.05873403,-0.075607195,0.023462834,0.070186816,0.01509244,0.02943331,0.06329831,0.06921307,-0.08667774,0.031126529,0.041356377,-0.04840216,-0.014899485,-0.008195933,-0.018984629,-0.00912589,0.032623906,0.011561683,-0.011463241,-0.032710887,-0.011185584,0.07276575,-0.11497131,-0.030489346,-0.044400796,0.060425054,0.07405173,0.01720027,0.038403507,-0.022313688,0.0064284685,-0.041824628,0.07766212,0.012377509,-4.0699046e-08,0.036032144,-0.031182349,0.021717973,-0.10489325,0.042174753,0.015925597,-0.039786633,0.001504315,0.061851326,0.05254229,-0.06528313,0.057079256,0.0023729887,0.040301934,0.019750163,0.027282283,0.005431729,0.014501421,0.02036481,-0.027456744,-0.027093481,-0.012345686,-0.08231767,0.0340651,0.02365116,-0.107830554,0.016939022,0.020211736,0.01758924,-0.032732952,0.047002483,-0.043022525,0.011258792,-0.013259368,-0.09978568,0.045015767,-0.058922015,-0.044781324,-0.0023031519,0.07155986,-0.04061644,-0.03235896,-0.08214768,-0.02531643,-0.062985346,0.0069510643,0.03710344,-0.022656435,0.0024084952,-0.025277628,-0.01388306,-0.024220992,-0.001547074,-0.030562527,-0.04638011,0.002789815,0.04351421,0.030048816,-0.031413108,-0.10748092,-0.00016485798,-0.06054722,0.11057397,-0.024965797 +4.2.3.166,"The enzyme has been identified in the bacterium Streptomyces pratensis. It is specific for (2E,6E)-farnesyl diphosphate.",384,1.0,-0.059487898,-0.034161836,-0.116960466,-0.020727756,0.0022074142,0.053579308,-0.052568913,0.09066013,0.065852396,-0.030445067,-0.014122746,-0.050179116,-0.055332083,0.042985257,-0.031062368,-0.014800073,-0.06333136,-0.0364679,0.10796679,-0.016030176,0.08946637,0.08710047,0.019789023,-0.044089504,0.041370746,0.017837103,0.066110425,0.021822913,-0.008441024,-0.06141907,0.018798718,-0.0097536575,0.043720137,-0.05445005,0.09474105,0.12739725,-0.017850468,-0.097389966,0.054371428,0.034910355,0.02102292,0.004499916,0.020235341,0.03321331,-0.05733987,0.035043057,0.077548526,0.11225133,0.03510902,-0.04264879,-0.017340885,-0.115863614,-0.04134973,-0.009047785,0.030713283,0.009921717,-0.016607758,0.002151206,0.018973123,0.01697045,0.063728586,-0.012395987,0.04128538,-0.027580226,-0.0029268926,-0.050428797,0.050934017,-0.09014283,0.04821098,-0.10807787,-0.12895428,0.005109723,0.0061464817,0.038248215,-0.018516056,0.02332899,-0.051722474,0.012632986,-0.006737924,-0.075176194,0.0332058,-0.06597155,0.009084197,0.055903424,0.043588847,-0.031914074,0.028047986,0.035615288,0.0936533,0.022178901,0.026279155,-0.0036737688,-0.06924075,-0.069623634,-0.078106634,0.03310185,-0.08605487,0.04345111,-0.010831916,-0.012735506,0.030996604,0.02634116,0.0058888504,-0.00601183,0.032228008,-0.0029638938,-0.072044134,0.05147915,0.029657332,-0.062275715,-0.006894767,0.07370861,0.040423468,-0.022649975,-0.0064029875,0.013365558,0.041656412,-0.07946634,-0.021080343,-0.0122948075,-0.040057376,0.031069513,0.021748036,0.05412178,-0.011211577,0.025364144,-0.12483623,1.0695238e-33,0.0021569934,0.06574691,0.105500355,-0.07710867,-0.03284242,0.0068495194,-0.09017819,0.001202027,-0.039262146,-0.0117975315,-0.04466345,-0.09768187,0.0827484,-0.01034084,0.04918358,0.0026910033,0.014459739,0.068730645,0.08119049,-0.058602277,0.010598301,0.04510871,-0.02204244,0.005502015,0.04776631,0.088414036,0.006822834,0.030933665,0.10294481,-0.046475515,0.072792105,-0.08690905,-0.070597656,-0.046783864,0.06419713,-0.09483346,-0.07508415,-0.050865352,0.004734137,0.00086590176,0.026174957,0.0070890095,0.01739092,0.06063244,0.050472707,-0.11279323,-0.03639092,0.059183378,0.06869413,0.051821485,0.014393599,-0.054152507,0.081697464,-0.01765823,-0.1087289,0.03482978,0.022909395,0.07903488,0.06624925,0.01811172,0.015900778,0.051944606,-0.013430629,0.0068986434,0.025478663,0.024246806,-0.050525974,-0.02417377,0.012494804,0.15287101,-0.03474625,-0.008977477,0.05298697,-0.015232423,-0.02069223,-0.052669324,-0.080884576,-0.0145326955,0.020625066,0.0020827013,-0.01578457,-0.053799562,-0.006622432,-0.058633815,-0.11058981,0.02602852,-0.042198934,-0.080186844,-0.00938332,0.11495088,0.036393322,-0.07709846,-0.13522334,0.001973776,0.009495859,-2.007732e-33,0.09797004,-0.057087637,0.015107194,-0.062004454,-0.016206022,0.018028555,0.008415091,0.02781918,-0.04569141,-0.069590494,0.085236296,0.010772435,0.037583876,-0.045305695,0.014559849,0.060354475,-0.020586118,0.08075644,0.05921424,0.028747365,-0.00468741,0.042991854,0.034655955,0.042027593,0.0052824127,-0.017381117,0.07550066,0.026359765,-0.0027828605,0.0381561,0.008786991,-0.008351497,-0.017527433,-0.026795382,-0.0748505,-0.018206771,-0.024544768,-0.023175469,0.100916006,0.011775099,0.03395507,0.044300854,-0.0018671382,0.08393278,0.0073203575,0.09159774,-0.021853458,0.023444338,-0.026291877,-0.040573623,-0.03302412,0.022279825,-0.010873963,-0.017661167,-0.019629454,-0.022376414,-0.07824221,-0.058677986,-0.025685435,-0.025952011,-0.021208813,-0.077173844,0.02133098,0.007013433,0.06818436,0.036716342,-0.05047773,0.0685689,0.057047036,-0.019044003,0.058921788,0.011349394,-0.05687048,0.020799177,-0.09600646,0.010277496,-0.0073667173,0.044110198,0.03763819,-0.009222097,0.006823766,-0.00451733,-0.020690136,-0.06425641,0.021819573,-0.0561079,0.06244256,0.06408103,0.00972208,0.045646403,-0.04429808,0.018450525,0.0065159756,0.005486454,0.052679013,-2.7552183e-08,0.06622487,-0.072382495,0.09107302,-0.04374323,0.04417368,-0.021157024,-0.0015372166,0.007997851,-0.047810882,0.018741727,-0.043136675,-0.02873256,-8.682877e-05,-0.043168318,0.059088565,0.016162636,-0.078434914,0.002855998,-0.042038683,-0.0070059462,-0.01825118,-0.013746951,-0.067858964,0.07116308,0.03567293,-0.0065024868,0.035652943,0.02454211,-0.012427075,-0.01798442,0.023337843,-0.013253061,-0.046257816,-0.038305447,-0.050890032,0.051465217,-0.03297669,-0.017852703,-0.049676213,0.05914137,0.023097998,-0.026137648,-0.06449345,0.018488165,-0.07783974,0.080647215,0.020412719,-0.0031080619,-0.03770172,-0.04584349,0.052584197,0.005365975,-0.04351441,0.022550885,-0.11445079,0.038104217,-0.042335965,-0.056567863,-0.08610309,-0.023899775,0.049555186,0.01906773,0.13736537,-0.035270024 +4.2.3.167,"Isolated from an ecotype of the plant Arabidopsis thaliana from Cape Verde Islands. The enzyme also gives (3E,7E)-dolathalia-3,7,11-triene and traces of other terpenoids. cf. EC 4.2.3.168 dolathalia-3,7,11-triene synthase.",384,1.0,-0.052136444,-0.043578107,-0.1335246,-0.0068305763,0.034006555,0.019917613,-0.018565701,0.026991762,0.088284284,0.007348,0.116041,-0.10513378,-0.07221723,-0.054255813,-0.019408975,-0.004881467,-0.0056252037,0.037301634,-0.00093771185,-0.06408339,0.07557389,0.090071544,0.040346354,-0.005903419,-0.025055245,-0.004090388,-0.016283628,0.008492074,-0.001013394,-0.05971087,-0.072766915,0.06446011,-0.011492613,-0.006114645,0.026062192,0.049583763,-0.030405568,-0.043660894,0.07089684,0.061313428,0.03632121,-0.011108785,0.030649276,-0.08278274,-0.080318876,-0.02479532,-0.050561696,0.014912602,0.019163791,-0.059864722,-0.029326854,-0.04061455,-0.056990743,0.011415536,-0.024198735,-0.069165304,0.10211624,0.021365207,0.0011684842,0.08401896,0.08638262,-0.03415413,0.055781383,-0.016064597,-0.049276248,0.023250215,-0.05635497,0.028761325,0.036899917,-0.08090282,-0.04441012,-0.025123388,-0.019968942,0.034025993,-0.062468454,0.07435798,0.012785317,0.05726993,-0.043412764,-0.037171505,0.052540835,-0.035107285,0.012590787,0.097576015,0.029936835,-0.017253628,-0.06577345,0.1095791,0.07361658,0.049914762,0.033927232,0.14192902,0.038488287,-0.0059489436,-0.032597587,0.07936473,0.033405207,-0.009245769,-0.026676824,-0.0012800625,0.068851024,-0.06200674,-0.031259455,-0.046126857,-0.09450439,0.056655146,-0.042120583,-0.10127365,0.054312997,-0.047319163,-0.055866107,0.023627598,-0.024043731,0.0009538711,-0.07087948,-0.01953365,0.05125385,-0.07643492,0.044408806,-0.034544036,-0.006744684,-0.0038117568,0.054933194,-0.0047521973,0.02107213,-0.01506349,-0.10815008,1.7371494e-33,0.072543405,0.13967873,-0.03430798,0.0029733048,-0.038578957,-0.015359679,-0.014683743,0.07492264,-0.12624209,-0.03899238,-0.071437314,-0.057504784,-0.01366075,-0.054895632,-0.021144317,0.009202532,0.057279564,-0.017320486,0.03044965,-0.062580705,-0.017164255,-0.018461391,-0.06807338,0.0133754285,0.006148559,0.01877327,0.011234297,-0.09372182,0.07565971,-0.047689836,-0.0119838575,-0.12707804,0.017909333,-0.020301554,0.04764971,-0.014179493,-0.070558116,-0.0053900625,-0.07576624,0.03404909,0.02490173,0.05572358,0.07787255,0.008909171,0.07430023,0.047729008,-0.039095886,0.028057182,0.107886896,0.046481688,-0.07271663,-0.0039918846,0.045851655,-0.035420075,-0.09822181,-0.010898512,-0.040989526,0.061404463,0.056344237,0.017589953,0.0017519757,0.03958581,-0.059575956,0.00329357,-0.045188557,0.10243221,-0.15210813,-0.060809594,-0.0021988314,0.053658187,-0.009995654,-0.06491762,0.081132054,-0.022684094,0.08719238,0.03770512,-0.023294711,-0.06812877,-0.0059502884,-0.025640836,-0.007710211,-0.0048074275,-0.0023851555,0.021401936,-0.106477045,-0.005881828,-0.022601968,0.023738729,0.030184647,0.031178974,0.09316261,-0.03376293,-0.059160933,-0.035870876,0.017958863,-8.9653705e-34,0.028789181,0.023282535,-0.023553886,-0.12688817,0.0065828683,0.05722752,-0.061092943,-0.00040128655,0.016125929,-0.02058125,0.09892975,-0.027494919,0.06894896,-0.10158806,-0.0006092891,0.0010361472,0.067955256,0.08889218,0.03692573,-0.031965274,-0.002324115,-0.043080583,0.007897912,0.016456326,-0.04647515,0.029355032,0.05564397,0.03866609,-0.014663321,0.014789436,0.016621035,-0.062011488,-0.015769187,0.06307472,-0.05358583,-0.0059561925,-0.07712819,0.0064338217,-0.018333172,0.066708714,-0.07352281,-0.03237054,0.007312679,0.06790132,-0.018651206,0.066426866,-0.05197423,0.012856772,0.012774554,0.043418836,0.060725544,0.027462518,-0.02316351,-0.018614171,0.070885204,-0.011629526,0.036133565,0.0358671,-0.016320394,-0.0187017,0.0510583,-0.032025155,-0.03865174,0.013339553,0.04046114,0.099744126,-0.043517336,0.062330015,-0.028932624,0.050770853,0.060462773,0.061504938,-0.063584484,-0.018115243,-0.014832821,-0.022381658,-0.0051830765,-0.10518621,-0.08365441,0.015508285,0.01776611,-0.0011193348,0.010232538,-0.03955022,0.008424949,-0.021074768,0.056419946,0.06075411,0.053511165,0.04713216,-0.017202,0.013758946,-0.077936515,0.052799422,0.058166374,-3.4338154e-08,0.0055485503,-0.033826534,0.025169648,-0.007816594,-0.017152948,0.01838461,0.049976718,0.046741974,0.026640655,0.044291615,-0.04077892,-0.047441926,0.053301543,0.033510584,0.123333104,-0.003530462,0.03469649,0.035085756,0.019398501,-0.0070698373,0.037365936,0.027265107,-0.06920079,-0.01900952,-0.0037616815,-0.038668487,-0.0142005235,-0.02712084,0.061284073,-0.013240631,0.03844855,0.032030355,0.0029391896,-0.034440078,-0.05079147,0.022004217,-0.031607762,0.024575327,-0.061697036,0.0313988,-0.0015338701,0.02726183,-0.10054098,0.05729549,0.0013071783,-0.040945668,0.008411852,-0.019219967,0.07265143,0.028029064,0.027338738,0.040397566,0.032215722,-0.014261934,-0.040265918,-0.1015094,0.0016775898,-0.0013211954,-0.061621968,-0.011235875,-0.019571662,-0.06470664,0.13441242,0.031693265 +4.2.3.168,"Isolated from an ecotype of the plant Arabidopsis thaliana from Cape Verde Islands. The enzyme also gives (3E,7E)-dolabella-3,7-dien-18-ol and traces of other terpenoids. cf. EC 4.2.3.167 dolabella-3,7-dien-18-ol synthase.",384,1.0,-0.03642727,-0.040189605,-0.123984404,0.026132556,0.027371733,0.03101195,-0.014458779,0.039980173,0.11437971,-0.028457547,0.11818925,-0.06191356,-0.07352251,-0.06101292,0.007377103,0.019988602,-0.012301587,0.03400932,-0.015564133,-0.05534418,0.060959097,0.09455533,0.046719883,0.0073490823,0.016902216,-0.015230215,-0.02210389,0.0405249,-0.005295301,-0.08051831,-0.059642978,0.033414103,0.044087052,-0.033017203,0.054389823,0.031161001,-0.015926102,-0.024368895,0.09666549,0.029149976,0.066802815,-0.011390182,0.06541425,-0.07038136,-0.12350097,-0.014269201,-0.043059587,0.014653459,0.02452772,-0.05232554,-0.025095658,-0.09281685,-0.036175076,-0.0042198165,-0.024940725,-0.07179696,0.08769425,-0.014888863,0.0037036245,0.102819264,0.031625014,-0.0062792455,0.036216646,0.0017140757,-0.03554116,0.027023163,-0.04274149,0.021664944,0.008133877,-0.07404071,-0.004121464,-0.04468061,-0.006791928,0.036350146,-0.07935456,0.08832911,0.040691566,0.047359705,-0.018592881,-0.0320935,0.0643554,-0.00096157426,0.0021246702,0.08512778,0.002561648,-0.030742968,-0.041466687,0.13114455,0.08276533,0.06498115,0.0038560638,0.093760654,0.0031098556,-0.028059835,-0.039782356,0.06913871,0.005138695,0.008568772,-0.023250284,0.033087082,0.05335142,-0.033320986,0.0008027963,-0.050775487,-0.07651394,0.06913429,-0.0331531,-0.09882505,0.021868002,-0.045767944,0.0027573837,-0.026949383,-0.022886999,-0.009711797,-0.06164499,-0.031546637,0.03719168,-0.07795274,0.0064394865,-0.039291475,-0.026167996,-0.01812846,0.08157071,-0.0006989432,0.0026964117,0.029033491,-0.09592386,7.6444055e-34,0.049014006,0.0817188,-0.03136685,-0.01851842,0.012794119,-0.021272168,0.015807042,0.085149795,-0.11510583,-0.00705309,-0.081889816,-0.063518636,-0.016263213,-0.040386144,-0.009889978,-0.018017188,0.084686555,0.018087246,-0.0010113949,-0.054753166,0.021791752,-0.022044681,-0.042509228,-0.0017143223,-0.013400439,0.020113746,-0.039148565,-0.080390945,0.11305613,-0.058607582,0.03876255,-0.11747402,-0.018685142,-0.018879399,0.04999914,-0.02567692,-0.100199685,-0.011763195,-0.07032909,0.04853051,0.009237042,0.087084256,0.07597215,-0.0017302542,0.1035626,0.039303873,-0.03674747,0.013332777,0.09732343,0.055153545,-0.05158098,0.0031727382,0.027240952,-0.04507553,-0.048394673,-0.03480591,-0.028073855,0.078251995,0.043437276,0.04095289,-0.002757017,0.059084725,-0.069704756,-0.03386284,-0.029727664,0.14033651,-0.1320465,-0.061193135,-0.01210128,0.04799486,0.0077205296,-0.09311578,0.045782562,-0.047091503,0.068944976,0.03540763,-0.037595857,-0.077507414,-0.02406744,-0.038282692,-0.015254225,0.0004628259,-0.03571036,0.02526445,-0.11464695,-0.0064587337,-0.025476888,0.04474823,0.015372429,0.043574743,0.0735429,-0.027304064,-0.09435365,-0.0026980476,0.00842428,-5.760823e-34,0.008605672,-0.002486025,0.0436013,-0.1483116,-0.02588601,0.05087811,-0.06620221,0.054601125,0.016462257,-0.0023170197,0.08466326,-0.014740945,0.06998427,-0.07378465,-0.017266357,-0.03697885,0.015410951,0.10225552,0.0038189946,-0.01307341,-0.021764616,0.03212753,0.004792663,0.06052238,-0.021928083,0.011213307,0.06294421,0.057703033,0.0054841856,0.019790707,-0.014199857,-0.044652626,-0.013139197,0.037541855,-0.05300021,0.01814129,-0.030524245,-0.014176534,0.0057237544,0.07405726,-0.08649735,0.007982542,-0.017052474,0.09512959,-0.018488877,0.052200854,-0.10018448,0.026551455,0.013765143,0.04836212,0.036111243,0.013763871,-0.03625427,-0.011736657,0.034682985,-0.03811865,0.033351365,0.022236465,-0.021027628,-0.05888406,0.04967485,-0.073338166,-0.016665148,0.035178374,0.048928536,0.084856056,-0.059862982,0.048427224,-0.030922057,0.046006802,0.020269543,0.04505843,-0.06699642,-0.0143408505,0.027198104,-0.014341145,-0.028873147,-0.13288763,-0.07411682,0.012721528,0.024061147,-0.0683183,0.0026831888,-0.009104101,0.033943783,-0.02096109,0.07692162,0.04400886,0.04276704,0.072765306,-0.0074104927,0.03228282,-0.045062874,0.09831578,0.04870868,-3.565643e-08,0.023970064,-0.04457047,0.04576973,-0.007973208,-0.020094847,0.017919816,-0.00054632145,0.0139781255,0.021316748,0.09397216,-0.05120436,-0.012614158,0.017606188,0.021717316,0.09771439,-0.013547383,0.023097804,0.030719878,0.013041431,0.0077016004,0.027789637,0.017691279,-0.044335607,-0.016124263,0.024788734,-0.08925112,-0.028530113,0.012563857,0.042132877,-0.023412164,0.04663028,0.029275969,-0.0005789929,-0.023200426,-0.03140098,0.032301027,-0.03719757,-0.019341553,-0.07475545,0.054872025,0.0066377046,-0.0023024825,-0.10739282,0.0072312993,-0.009018512,-0.013791179,0.031954236,-0.005633908,0.008486879,0.02367848,0.021030987,-0.011037938,0.024740389,-0.0272008,-0.037438776,-0.10717813,-0.013125295,0.011525257,-0.060198326,0.042186946,-0.0024884264,-0.041291412,0.17258601,-0.004825269 +4.2.3.169,"The enzyme, found in the bacterium Streptomyces viridochromogenes, is specific for (2E,6E)-farnesyl diphosphate.",384,1.0,-0.054931864,-0.026653668,-0.10213366,-0.022886721,0.02788288,0.054374322,-0.08017995,0.09734987,0.06573863,-0.03831559,-0.0040096776,-0.072054595,-0.04909123,0.0283721,-0.006579353,-0.042773027,-0.04475716,-0.01259201,0.07801638,-0.0080707,0.09428111,0.07448853,0.031312406,-0.05847961,0.040855493,0.037462607,0.048129782,0.027970534,0.013667203,-0.05438621,0.010004724,0.0011603042,0.025012413,-0.02215842,0.122905344,0.10687867,-0.012333737,-0.08076548,0.027134182,0.03205903,-0.0065549533,-0.0019962299,0.05161005,0.027228147,-0.048122425,0.026292924,0.054661088,0.10351736,0.041983422,-0.034095585,-0.020821815,-0.12032521,-0.056887332,-0.013198451,0.039595407,0.012518212,-0.034434386,-0.03410309,0.012997002,0.04218963,0.0745673,0.0024257598,0.052888315,-0.017561078,-0.0004778598,-0.053363,0.05653381,-0.074569136,0.04283711,-0.09106506,-0.12782998,-0.029284466,-0.015375723,0.033267546,-0.026579918,0.02620856,-0.040225282,-0.0070132995,0.019033615,-0.08976321,0.018689772,-0.084606774,0.011541893,0.05764046,0.025806002,-0.045836724,0.035670463,0.01707864,0.11053493,0.025649315,0.038336728,-0.0146875195,-0.036821295,-0.09498289,-0.05151415,0.031338103,-0.050503243,0.040454805,0.031014131,0.0027302287,0.021849858,-0.0044562668,0.010141052,0.013613132,0.02978484,-0.022724325,-0.059709962,0.07724796,-0.0022177943,-0.091941796,0.0014110467,0.07414488,0.065440685,-0.024333114,0.012447185,0.00835178,0.057889603,-0.08886333,-0.054971196,0.037674736,-0.032898016,0.021621197,0.047275446,0.055672087,-0.035159662,0.027032133,-0.08103093,6.9694706e-34,-0.0051375125,0.058625363,0.09045931,-0.07193658,-0.063368246,0.043651044,-0.057449777,0.03126151,-0.08012456,-0.0051863203,-0.03533525,-0.10046198,0.089333065,0.021634776,0.063285545,0.016350528,0.006684919,0.045123424,0.072023585,-0.08730297,0.042747546,0.031010501,0.007934516,0.003122401,0.015954904,0.08414933,-0.012962747,0.009154662,0.10795271,-0.035992853,0.068522,-0.06818817,-0.035824195,-0.029203692,0.06339008,-0.057227317,-0.10251845,-0.06757348,-0.007760727,-0.03172966,0.045962226,0.0059657753,-0.028753579,0.017722193,0.03905852,-0.1115774,-0.05079385,0.044829562,0.03390906,0.023626845,0.0067440215,-0.026451483,0.077025354,-0.035128046,-0.08051508,0.05636496,0.03871956,0.08263062,0.046115,0.0011972656,0.008525056,0.038430266,-0.014442235,0.026065573,0.047032636,0.009540547,0.010174042,-0.04991372,-0.013167693,0.16424252,-0.023680909,-0.020242957,0.030307682,-0.01281627,-0.009045977,-0.064945966,-0.0916543,-0.03575321,0.023429807,-0.016319482,-0.01147947,-0.018482655,0.0027555805,-0.07307057,-0.088136934,-0.004444984,-0.047521476,-0.079066694,-0.001057268,0.116027564,0.044835284,-0.09254899,-0.11040912,-0.0059465626,0.030075263,-2.3222954e-33,0.0909897,-0.03731696,-0.011175723,-0.072459236,-0.010014472,0.026130732,0.033846073,-0.016464073,-0.03699618,-0.03831768,0.08642537,0.0071547143,0.0038409096,-0.06642644,0.0034812079,0.032354373,-0.0043088975,0.07899866,0.0785977,0.026168492,-0.0064332727,0.030188207,0.059103467,0.057372846,0.014650057,-0.0141162,0.041945454,0.028827135,-0.02627313,0.06849051,0.002106136,0.02022872,-0.0005082853,-0.037735563,-0.05409131,0.007941298,-0.040699385,-0.025681023,0.10251538,0.014615445,0.022960227,0.06869526,0.009567482,0.050411463,0.002246364,0.08953427,-0.030608367,0.043453418,-0.034176204,-0.08918196,-0.0355045,-0.010897411,-0.028644476,-0.025223553,-0.020168573,0.006903624,-0.07854959,-0.053753767,-0.016019728,-0.043578,-0.04349026,-0.066662125,0.009823155,-0.022114174,0.065648444,0.05776368,-0.03296561,0.05135242,0.07939838,-0.058702257,0.051059052,0.0064067678,-0.023473332,-0.0052337134,-0.072867855,-0.0048757414,0.016703378,0.035409275,0.033749226,-0.054618884,-0.003796229,0.0048277345,-0.0079546375,-0.047449317,-0.007481912,-0.07805836,0.036765654,0.083482474,0.028657926,0.04486748,-0.06575403,-0.006078374,0.013600805,-0.001980257,0.06664288,-2.7825475e-08,0.07300698,-0.06731413,0.09978058,-0.039464995,0.06491685,-0.01607333,-0.012805746,0.050214708,-0.0037103798,0.03438521,-0.02062725,-0.02923001,0.013193783,-0.05424378,0.051708113,0.025623953,-0.1107712,0.016420068,-0.04642711,0.01026836,0.008878257,-0.0063161436,-0.047458816,0.06685057,0.037305254,0.011728031,-0.0033665667,-0.011888929,-0.038468976,-0.012962951,0.06363749,-0.003757623,-0.047943436,-0.010295117,-0.09579927,0.029934905,-0.03307384,-0.031129073,-0.058486283,0.047378,0.017808573,-0.014491897,-0.09115823,-0.004629777,-0.069324635,0.08579539,0.015577873,0.0005687995,-0.035138328,-0.036196496,0.009226581,0.0008972658,-0.055661835,0.019959697,-0.08973851,0.000669907,0.0048363763,-0.07232326,-0.07564666,-0.041941553,0.037768967,0.007818914,0.18093729,-0.051614758 +4.2.3.170,"The enzyme, found in the bacterium Streptosporangium roseum, is specific for (2E,6E)-farnesyl diphosphate. 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+4.2.3.171,"The enzyme, which forms the sesquiterpene (+)-corvol ether A, has been reported from the bacterium Kitasatospora setae.",384,1.0,-0.039747015,-0.010198863,-0.10249659,0.035722505,-0.048211683,0.034970965,-0.0958394,0.06755172,0.07450189,0.020836068,0.06930525,-0.13068514,-0.025860148,-0.022172123,-0.058582544,-0.08694491,-0.05050977,-0.07993396,0.047150537,-0.04997438,0.045740955,0.06675842,-0.00087396306,0.013564044,0.07355595,0.05645862,-0.0063848845,-0.024017684,0.032563634,-0.11208508,0.0034846615,0.0349785,0.028143596,-0.11906117,0.07891891,0.032500826,-0.010293321,-0.0443447,0.12673518,0.04178563,0.0389981,-0.0006165168,0.06340888,-0.06902891,-0.09292037,0.047425028,0.049761146,0.01674164,0.063245095,0.002635067,0.020738585,-0.03522339,-0.0632113,0.017679583,-0.045352504,-0.044102103,0.021334492,-0.057500016,-0.018870914,0.039207105,-0.0046121064,0.037026986,0.03600982,0.036536705,-0.032158174,-0.022590507,0.014415595,-0.04238831,0.03895355,-0.038317528,-0.060803026,-0.09404624,-0.023949845,0.076116115,-0.0337074,0.053539075,0.053344663,-0.0070870863,0.0046597063,-0.031446,0.038128473,0.0280755,0.03489033,0.08159575,0.015192788,0.04541126,-0.016950792,-0.10252081,0.11595522,0.06828923,0.030052086,-0.013032289,0.019329458,-0.054317173,-0.029086096,0.049674287,0.034637596,0.07020966,-0.034375962,-0.041647326,0.005980918,0.018639622,-0.067684285,-0.06137341,-0.044967007,0.017488234,0.031989202,-0.00908029,0.13629618,-0.0077774446,0.040197372,-0.0189683,0.029156959,-0.059028056,-0.0233434,0.059473164,0.079351895,-0.04614449,-0.011855842,-0.0024435597,0.038286004,-0.10223407,0.045531012,-0.0047006803,-0.0048182816,-0.0007156558,-0.05771338,-7.930441e-34,0.03774649,-0.017793782,0.028342523,0.0062841056,0.032429572,-0.018583076,-0.053924486,0.08767593,-0.0905444,-0.12719561,-0.12963142,-0.073927015,-0.048847374,0.08759595,-0.09091604,0.06086806,0.027589303,-0.05215356,0.011927599,-0.051871646,0.037781075,-0.013301528,-0.0014102206,0.013296407,0.0585961,0.0373743,0.0038455206,0.0058101392,0.048892744,-0.018967355,0.022688497,-0.043536026,-0.04281767,-0.005020044,0.039982818,0.022259103,0.021365145,0.029051054,-0.08988021,0.038142256,-0.01291562,0.08357166,-0.033904806,-0.03639013,0.04792871,-0.04309595,-0.061716307,0.04963042,0.060262945,0.034328856,0.009690351,-0.024450732,0.050797414,0.07476228,-0.051363323,0.05998559,-0.07930355,-0.015355563,0.016552793,0.044981156,0.063365966,0.1068331,-0.0155561315,-0.0044231075,-0.02131838,0.06532396,-0.031059416,-0.037786096,-0.009617901,0.0509831,-0.06545439,0.016911067,-0.028119061,0.027168501,0.069453694,-0.0053949743,-0.09100032,0.0030504868,0.02389237,-0.0018762201,0.022843266,-0.09282029,0.08153403,-0.025912283,-0.0662176,-0.018464344,0.0027110798,0.034987643,0.016584499,0.0075155008,0.07716796,-0.055627,-0.022855327,-0.009297829,-0.08042217,-1.2822077e-33,0.008939422,-0.088839054,0.010544291,-0.031736366,-0.050154813,0.052404877,-0.027280312,-0.030489247,-0.018641487,0.0521455,0.07164227,0.028723473,0.02439111,-0.085263826,0.016741093,-0.05375802,-0.019328414,0.073453784,0.02690523,0.019047571,-0.0031714516,0.0341193,0.014392531,-0.033628214,0.0035523728,-0.027948601,0.030632291,0.00018189331,-0.073930226,0.0189802,-0.0065790946,-0.0035255076,-0.00010347691,0.0034125561,-0.104538195,0.010681322,-0.04637196,-0.035786305,0.0069891578,-0.014684634,-0.0069140866,0.03760043,0.0022343216,0.060305696,0.0861061,-0.03123701,-0.13556196,0.017202418,0.04180516,0.010941697,0.06229778,-0.033582196,-0.008099541,-0.020305289,0.0064264038,0.044894103,-0.007809997,0.013056212,0.036897566,-0.025128897,-0.018372213,-0.04242074,-0.033735488,-0.018324727,0.13103017,0.03363193,-0.012071127,0.051552452,0.03523457,-0.054116298,0.089244284,0.014656169,-0.037227202,-0.01342467,-0.02631327,-0.034486383,-0.0070779584,-0.108416624,0.011765651,-0.029955318,-0.10314025,-0.074087925,0.04967711,-0.085423954,-0.03508252,-0.02728414,0.03411152,0.08394386,-0.013575349,0.1130365,-0.037226364,-0.01443185,-0.026385736,0.061531883,0.10623109,-3.1503628e-08,0.026016967,0.009526828,-0.0110659925,0.0681049,0.020916224,0.020129627,0.036444236,-0.03627785,0.04352989,0.0036691886,-0.013071608,0.07037543,0.021479566,0.014907255,0.07389672,-0.008900127,-0.03239524,0.027266989,-0.05857732,0.0036131502,0.047297988,0.016048787,-0.059245847,0.0268715,0.031772517,-0.11405948,0.006748711,0.08323267,-0.024143208,-0.0270533,-0.07220725,0.023066644,0.038086355,-0.052269973,-0.08850934,-0.04179277,-0.036318373,-0.0069108163,-0.0390065,0.09190257,-0.00022569271,-0.100526795,-0.054559574,-0.03314481,-0.010602558,0.081572674,0.041115478,-0.0049630213,-0.02488562,0.011830418,0.07002333,-0.010499117,0.061845466,0.038726278,-0.064057775,-0.019791562,-0.056666087,-0.0037866856,-0.026914105,-0.07845331,0.017388143,-0.03363199,0.12162861,0.06295047 +4.2.3.172,"Isolated from the plant Inula hupehensis. The enzyme also gives gives tau-cadinol and traces of other terpenoids, see EC 4.2.3.173, tau-cadinol synthase.",384,0.99999994,-0.051787592,-0.027582565,-0.0714427,0.03375568,0.015321437,0.034845594,-0.0031205956,0.04949329,0.07208547,-0.034902073,0.09364836,-0.015975503,-0.019295832,-0.045095578,-0.06031653,0.032907743,-0.010227608,-0.023087742,0.06957927,-0.0208692,-0.011047381,0.030204108,-0.02561515,0.025475232,0.043438297,-0.0024340975,-0.001018542,-0.0016315706,-0.0109997215,-0.10922748,-0.043199416,0.019879503,-0.019382909,-0.09280723,0.00755847,-0.012881126,-0.0263245,0.009050145,0.11843759,-0.05226466,0.07748919,0.012402657,0.04750194,-0.038783684,-0.06910504,-0.028690182,-0.048441384,0.011114157,0.048532214,-0.044491854,-0.02827933,-0.026297364,-0.0003701569,0.023289632,-6.0849383e-05,-0.0001148888,0.043933142,-0.10512382,-0.0014904317,0.030989204,0.01309115,0.011188795,-0.04744869,-0.021293603,-0.09668772,0.004472622,0.0017875686,0.053026114,0.062325142,0.001423007,-0.0045937165,-0.03806796,0.03765121,0.07552084,0.0027511052,0.06753105,0.009598122,0.015074691,0.01700322,-0.087925665,0.02161894,0.05132868,-0.0019760614,0.052443754,0.10003163,0.029655935,0.036504865,0.055729672,0.05366927,0.008074808,0.045187507,0.09678439,-0.05764013,-0.04901531,-0.059432384,0.033949275,0.08769417,0.06582886,-0.028647667,-0.02227905,0.06376414,-0.03462661,0.019105144,-0.12225866,-0.09723406,0.075013235,-0.063420184,-0.09550033,0.09444788,-0.059727143,-0.03723611,-0.06896397,-0.010576327,-0.027186494,-0.0066581564,0.0103890775,0.028838065,-0.09257137,-0.0035557088,-0.020351568,-0.031716526,0.0030402837,0.09948513,0.0059505254,-0.0620206,0.06918627,-0.026473738,1.7755122e-34,0.02372037,0.09414816,0.0049554724,0.02085628,0.031356134,-0.04020777,-0.04917722,0.0020144766,-0.07926813,-0.08156582,-0.074462205,-0.084895276,-0.052185897,0.0058661303,0.02485891,-0.029068079,0.07524642,-0.011408291,0.05803704,-0.04257755,-0.03143839,0.03763325,-0.110266656,-0.027577477,0.04200853,0.051200256,-0.030440198,-0.05563236,0.02533794,0.027369898,0.057408467,-0.021294402,-0.054029472,0.03200643,0.022708258,0.019557962,-0.011124522,-0.02856176,-0.050590117,0.06196484,0.07980353,0.04645186,0.06841066,-0.0069902027,0.007923208,0.010447826,-0.02943871,-0.0049198694,0.05424621,0.032107487,-0.035652544,0.0018237515,0.052408192,-0.04937953,-0.060860816,-0.003057263,0.023562573,0.026012182,0.09530069,0.049683977,0.01375903,0.081370994,-0.052110966,0.00972005,-0.049743477,0.04144846,-0.12005889,-0.05472594,-0.05655782,0.08655729,-0.071958154,-0.013830029,0.03178475,-0.03655172,0.050918013,0.047031675,-0.075799614,0.0049282685,-0.033184957,-0.026627917,-0.075290404,-0.04444743,-0.022909354,0.016865423,-0.016074019,-0.003561214,0.05225536,0.08390408,-0.035441745,0.052373357,0.07657922,-0.01452962,-0.07994843,0.018539343,-0.04423745,-1.0035291e-33,0.032218616,-0.024465801,0.060651183,-0.10761348,-0.088207595,0.13766135,-0.04779168,0.047831085,0.03343735,-0.019079007,0.10456088,-0.014536299,0.046015423,-0.03899407,0.032826107,-0.008069156,0.021247385,0.10915602,-0.0364648,-0.05326655,-0.024227645,-0.011966156,-0.024967536,0.045882016,-0.014828825,0.01809076,0.026943443,-0.02340199,0.018154988,0.03351377,0.015725393,-0.00081313006,-0.033946857,0.0031456633,-0.073004134,-0.018787723,0.031410083,-0.038763374,-0.01829039,0.049721316,-0.029442415,0.03838755,0.0028054847,0.10651239,0.028863572,0.039560426,-0.060469218,0.021650856,-0.028986232,0.017399337,0.12913333,-0.011965473,0.034369268,-0.04442822,-0.013143534,-0.06049636,0.031425342,-0.032404352,-0.048363645,-0.058619212,-0.02606866,0.030635264,-0.075079516,-0.0071685705,0.07006517,0.06672681,-0.0629479,0.007697771,-0.029545302,-0.0031239858,0.023878396,0.057013832,-0.04815731,0.034637827,0.046792075,0.06744421,-0.045114048,-0.11976868,-0.0041447096,0.008653217,-0.016271671,-0.06713606,0.02427494,-0.033901475,-0.03808088,-0.04938833,-0.015363794,0.024335435,0.0811833,0.040929165,-0.029058581,0.046791755,-0.09462326,0.06884409,0.06570909,-2.6781773e-08,0.029733364,-0.044319928,0.003283837,-0.034539428,-0.04853261,0.025436895,0.032364234,-0.02191731,0.10871527,0.02963532,-0.09474438,0.05279821,0.01918735,0.05731396,0.016010365,0.05138068,0.045930803,0.013457444,0.007032466,-0.00082433806,-0.025854636,0.028774308,0.011663721,0.0035896427,0.026606346,-0.094483696,0.04516049,-0.00046022475,0.014129012,-0.041324034,0.008541812,-0.03739461,-0.11009942,-0.0026120492,-0.0046506827,0.064909406,-0.029103613,-0.047024854,0.006774992,0.07889608,0.06148388,-0.027140152,-0.09969507,-0.011151138,0.00046249462,0.011537985,0.009605817,-0.023694063,-0.0010318698,-0.06278121,-0.055434342,0.0049333097,0.04461284,-0.08587677,-0.13175754,-0.01276204,0.039652523,-0.022515073,-0.0011282268,-0.11342946,-0.016785411,0.004329102,0.17501725,0.11029726 +4.2.3.173,"Isolated from the plant Inula hupehensis. The enzyme also gives 10-epi-juneol and traces of other terpenoids, see EC 4.2.3.172, 10-epi-juneol synthase. It has also been isolated from the plants maize (Zea mays) and lavender (Lavandula angustifolia).",384,1.0,-0.030289853,-0.042742632,-0.08993055,0.017303862,0.05649408,0.06698953,-0.03151868,-0.03515146,0.03677084,-0.014409536,0.13417883,-0.02969959,-0.0051983036,-0.060058247,-0.026295032,0.025390046,-0.014160928,0.0049746884,0.031934813,-0.041784205,0.018641235,0.048575345,-0.015430373,0.011083435,0.009325912,0.00094139634,-0.0031165492,0.038014267,0.027660264,-0.119404316,-0.015538728,0.03499336,-0.047207832,-0.110916585,0.0096457545,0.019598406,-0.039062183,-0.04539102,0.09761706,0.0019961228,-0.017416148,-0.0365597,0.0158487,-0.074469015,-0.07167922,-0.024423605,-0.03700332,0.019208834,0.022958094,-0.07536289,0.0107982615,-0.040894054,0.008935546,0.018365642,-0.019220253,-0.060699828,0.014270265,-0.014031828,-0.018296741,0.08392219,0.0337933,2.7795262e-05,-0.015889665,-0.010113976,-0.10868477,0.026110118,0.0035879395,0.01300381,0.003379222,-0.066688225,-0.022540221,-0.07355148,0.025020039,0.12607042,0.0018086884,0.06882934,0.016026717,0.011811352,0.044026818,-0.03561786,0.04433301,0.045968372,0.03544135,0.060251586,0.033561617,0.0013439959,0.011002333,0.08628486,0.057753958,0.02480619,0.05253644,0.059259403,-0.038932405,0.011762329,-0.0294249,0.04571333,0.024782995,0.038104456,-0.0021329166,-0.02761347,0.06742933,0.012303587,-0.019272992,-0.0876347,-0.10758189,0.07345645,-0.010566674,-0.10466386,0.07531249,-0.026926128,-0.013778218,-0.07480839,0.033399913,-0.021892149,-0.030034477,-0.063464716,0.05247615,-0.09996841,0.0036247538,-0.00645852,-0.0034146374,0.0035906874,0.09352713,0.057026908,-0.017799946,0.07216052,-0.066500254,2.1778772e-34,0.025920212,0.08224291,-0.0008680269,-0.0013149213,0.035982866,0.01598394,0.01937002,0.05560727,-0.08238375,-0.111475706,-0.12865528,-0.06179128,-0.031033063,-0.007842855,0.019037707,-0.004605815,0.052786924,-0.007811842,0.086231254,-0.03392519,-0.020727513,0.033271264,-0.10648412,-0.008606532,0.013977965,0.053211898,-0.0058705304,-0.0390694,0.099984646,0.0055746296,0.07093025,-0.085465856,-0.013974967,0.010339253,0.005792568,0.004915635,-0.04746513,0.009056166,-0.062509395,0.05107121,0.07290877,0.10670152,0.066459924,-0.043130424,0.011591137,0.011789821,-0.041235227,0.007648221,0.09864323,-0.041705053,-0.034780014,0.018371861,-0.014996099,-0.0330359,-0.07182669,0.08274527,-0.030964626,0.07030559,0.08609066,0.014918229,-0.038052935,0.11827361,-0.024150982,-0.02968744,-0.023226094,0.048914477,-0.12864909,-0.04622904,-0.07171479,0.026728125,-0.06637035,-0.0101284245,0.047269147,-0.0948351,0.039324794,-0.019052504,-0.0008271524,-0.041420713,-0.00899679,-0.029989947,-0.008297788,-0.021719007,0.051803857,0.050453126,-0.04033038,-0.06906116,-0.03515739,0.110379376,-0.036084104,0.04920332,0.06663928,-0.06469461,-0.07367059,-0.011610675,-0.024506776,-1.35714735e-33,0.061666366,0.007120074,0.112247795,-0.060861222,-0.016672798,0.11468531,0.0076097636,0.064705014,0.0059912857,0.013799085,0.08387397,-0.00785483,0.10779903,-0.044867866,-0.017267423,0.00809744,-0.004543781,0.1320609,-0.014143999,-0.012284289,-0.09324101,0.042186078,0.028155988,0.0298137,-0.038269304,0.04378101,0.053038344,-0.015571889,-0.004232252,0.019776657,0.07184582,-0.040949367,-0.076584265,-0.04614096,-0.0913688,0.010451519,-0.03377867,-0.077048585,0.0060210777,0.07030991,-0.018027185,-0.018089386,0.026655272,0.008928902,0.020610167,0.022583455,-0.0514109,0.010616329,-0.023554387,0.0049873847,0.04959737,0.035449028,-0.03790163,0.0039634514,0.022150021,-0.08002278,-0.00037478664,0.037803635,-0.05195589,-0.05029596,-0.0067401035,0.012038981,-0.05366471,0.038721647,0.062413894,0.082060605,-0.12564482,0.0057442333,-0.012309393,-0.006923574,6.65073e-05,0.0050274055,-0.061349433,0.024378425,0.0321195,0.045916595,-0.05022411,-0.15625726,-0.034187164,-0.00043031794,-0.03528027,-0.06581513,-0.0052946787,-0.0070414594,-0.021007745,-0.065012254,-0.024170097,0.02828333,0.0511098,0.029036805,0.016355284,0.025610998,-0.094848305,0.037441384,0.085688844,-3.135243e-08,0.043043066,-0.080695406,0.047070134,-0.0058570975,-0.056291763,-0.034021713,0.04687837,-0.0063654818,0.08541488,0.0044153924,-0.021244586,-0.0021114845,-0.00092800433,0.073837,0.061327055,0.006508591,0.027744345,0.03632446,0.013907102,0.005680991,0.0067015653,-0.010921307,0.027328864,0.008425251,0.05263863,-0.09591458,0.019824808,-0.025432423,0.0474774,-0.042995572,-0.011803095,-0.019563153,-0.053523608,-0.01545762,-0.026891079,0.07349568,-0.04455686,0.008319534,-0.0637748,0.020958599,0.060758848,-0.09385856,-0.04693334,0.00857886,0.0075594364,0.006250833,0.00752736,-0.0011267622,0.047706746,-0.08811598,-0.050787322,-0.0010079053,0.05502591,-0.049297,-0.03646355,-0.0093265595,0.0009825733,-0.0042815083,0.053885177,-0.09961938,-0.034933146,-0.0054827784,0.12643111,0.08726117 +4.2.3.174,"Isolated from the plant Camellia brevistyla. See also EC 4.2.3.187, (2Z,6E)-hedycaryol synthase.",384,1.0,-0.067651846,0.002474891,-0.1281962,-0.0027064602,0.04692732,0.08400504,-0.063293636,-0.034961905,-0.0086233765,-0.0047516758,0.060904726,-0.055524614,0.010570125,-0.053826045,-0.012387233,0.015913522,-0.05541488,-0.013019344,-0.01856326,-0.07870795,-0.009356724,0.06877134,0.037778303,0.039485425,0.05827327,0.031887636,0.050317433,0.0045629684,0.0071299286,-0.110196285,-0.09099696,0.022282345,0.036416788,-0.08011179,0.0071719196,0.015850175,-0.018149098,-0.028529523,0.15612768,0.0658283,0.039571654,-0.030094018,0.034393746,-0.09826493,-0.073368825,-0.026619367,-0.02748882,0.02605588,0.06795877,0.00041954336,-0.0072443867,-0.029297827,-0.026177194,-0.01661751,-0.020778371,-0.0935711,-0.03204765,0.020163754,0.043920595,0.02269552,0.09322665,0.07334885,0.013827707,-0.0048299883,-0.057428446,-0.018053873,-0.012026465,-0.040355563,0.050762612,-0.04279772,-0.039502062,-0.0849361,-0.03148692,0.04664797,-0.060102765,0.059668664,0.014957418,-0.08198937,0.05427998,0.0579888,0.0060756984,0.019194407,0.02989711,0.01783991,-0.0069808266,0.021951992,0.037881106,0.12089179,0.02319557,-0.046690084,0.022970939,-0.022577725,-0.0016948865,-0.0012656598,-0.06067038,0.029567368,0.06971358,0.064543255,0.018784655,-0.008883283,0.02521607,-0.053316712,0.072432786,-0.06913068,-0.049110107,0.03720598,-0.07587321,0.012500873,0.05311263,-0.04957424,-0.06467264,-0.011952276,-0.01729595,-0.0049238,0.02219018,0.10427239,0.0079417955,-0.022519277,-0.04718181,-0.019027183,0.030461716,-0.0027161494,0.119866,0.061649047,0.00828009,0.035636745,-0.13559985,-3.5785372e-34,0.043203775,0.024846012,0.07096775,-0.015653977,0.009297786,-0.010783081,-0.040620286,0.06884312,-0.09876812,-0.059777405,-0.08985658,-0.0017736789,0.05501045,-0.0030384439,-0.0016248693,-0.049202032,0.0081131775,-0.042600982,0.0038484822,-0.04575513,0.041647233,0.10204593,-0.021702986,0.024185251,-0.022087198,-0.027961867,0.0626685,-0.088572256,0.08405865,0.011592619,-0.015865084,-0.090682864,-0.029100375,0.021988126,0.005766226,-0.05064733,-0.09938579,-0.08301775,-0.014312682,0.03661243,0.0667902,0.01726787,0.03439418,-0.058097865,0.0041144053,-0.002863162,-0.043457527,0.029883083,0.08015787,-0.024378622,-0.028904524,0.08339334,0.0861879,-0.014659735,-0.052911393,0.03640143,0.049818754,0.029211307,0.047588255,0.06532786,0.033289544,0.105499424,0.00087493507,-0.014977964,0.034505654,0.03626434,-0.10428531,-0.05830494,-0.014958462,0.011788919,-0.014878726,-0.05159532,0.03149375,-0.04308622,0.09842007,-0.022206651,-0.027392106,0.0016708145,-0.03171736,-0.01642722,-0.03600382,0.039014272,0.020082466,0.025831467,-0.045650393,-0.036962166,-0.04775337,0.069054596,-0.08586515,0.059219457,0.026902014,0.0018989693,-0.07978195,-0.027186774,0.021750985,-1.0614855e-33,0.07830012,-0.009585515,-0.006912887,-0.06565461,-0.07846104,0.06847391,0.04031445,0.045816086,0.057694968,0.0029619182,0.064586446,-0.008034644,0.103575855,-0.07563001,0.012612675,-0.011759354,0.029352158,0.06274541,-0.028644936,-0.05194186,-0.04310483,0.022772321,0.0140112275,-0.03829147,-0.009737965,-0.03777414,0.025803408,0.045558568,0.022118598,0.0641534,-0.026466753,0.02471211,-0.037905995,-0.0378165,-0.0785296,-0.042360947,-0.079260804,-0.0639661,-0.046328656,0.004396509,-0.042629715,0.05469652,0.0021634728,0.089012146,0.11260634,0.047138825,-0.03369119,0.056775704,-0.031934213,0.010172598,0.033413816,0.03556082,0.011809886,-0.0557734,0.07128616,-0.022755954,0.029632144,0.022364669,0.014726405,-0.035688628,-0.01039031,-0.040776256,0.0066040675,-0.033054337,0.058795556,0.08530712,-0.08722197,0.015070283,0.048301462,-0.044464316,0.13790897,-0.001757816,0.03068635,0.053789604,0.06313268,0.044795614,-0.04446705,-0.0804324,0.0057291635,-0.04084759,0.027438963,-0.08266656,0.025697574,-0.021352563,0.006193729,-0.046248835,0.023181336,0.051051524,0.048103195,0.055771478,-0.010822572,-0.0012371711,-0.10433717,0.046718646,0.07271074,-2.7528431e-08,0.032107655,-0.03681374,0.047136262,-0.035227947,0.016339242,0.063112125,0.014389002,0.004859878,0.08617812,0.007820501,-0.0056971335,-0.035432633,0.036780808,0.05193944,0.0033218572,0.043263827,0.040746205,0.064908944,0.0070771705,-0.015963752,-0.07745843,-0.04101029,-0.033281963,0.008665768,-0.021798106,-0.081642956,0.062468596,0.010271566,0.025284301,-0.060557477,-0.07181043,0.0023497024,-0.041631058,-0.07108808,-0.029365106,0.028780121,-0.088093765,0.03215271,-0.00870741,0.036820382,0.009334955,-0.058452487,0.0014049227,0.008039824,0.007472249,0.018893564,-0.008025366,-0.0047743223,0.00093501376,-0.10071413,0.024324091,-0.011960372,0.07483237,-0.10427089,-0.07541414,0.010791427,-0.04958587,-0.09381096,-0.02074914,-0.069520794,-0.059142947,0.0012445305,0.16722064,0.049705278 +4.2.3.175,"Isolated from the bacterium Sorangium cellulosum So ce56. The enzyme is also responsible for the formation of trace amounts of many other sesquiterpenes, mainly cadinanes and cubebanes.",384,1.0,-0.018734353,-0.057118956,-0.120208874,0.08068217,0.022025555,0.03933237,-0.022610983,0.06628606,0.06479868,-0.073645115,0.09075612,-0.06491515,-0.0058347415,-0.057264186,-0.07296481,-0.08326446,-0.00093954155,-0.02554761,-0.013564783,0.01921061,0.032133315,0.04585869,-0.027996002,0.023334678,0.09561494,0.022879312,0.0034162193,-0.057287987,0.06519577,-0.09630013,0.039205655,0.030543908,0.042170763,-0.05206601,0.08111716,0.0216224,-0.025406307,-0.00066821935,0.05138177,-0.010296404,0.01601897,-0.011305268,0.0654698,-0.07726231,-0.015552029,-0.00082932634,-0.02677948,0.042857755,0.010555919,-0.021409372,-0.0028895193,-0.04146008,-0.057591174,0.029386502,0.007478523,-0.07115004,0.055417713,-0.037478358,0.0098455995,0.058427844,0.019915244,0.028074918,0.06283555,-0.018075148,-0.024443172,-0.029016927,0.02629384,-0.015568357,0.023523552,-0.030541359,-0.07427367,-0.057200126,0.015443618,0.07957529,-0.036963545,0.0464887,0.0028843442,-0.04647266,0.05449148,-0.049333096,0.014791276,0.036104165,0.032873757,0.12613642,0.0012806312,0.042661007,0.0035612928,0.050265897,0.027253592,0.011542097,0.07431157,0.056536112,-0.05081594,-0.0445068,-0.08240486,0.0653173,0.10870876,0.05813692,0.0762203,-0.063223,0.047699004,0.029587861,-0.033980377,-0.07319553,-0.055922087,0.055682603,-0.025686754,-0.020388128,0.06305446,-0.054211844,0.012419475,-0.017353183,-0.05900216,-0.09330386,-0.014297706,0.043755233,0.085604705,-0.05947881,-0.03776327,-0.018916951,-0.012778908,0.017946128,0.04905921,0.030159555,-0.0021714221,0.046165444,-0.043464653,7.802472e-34,0.024849711,0.00681364,-0.0013501305,0.013121286,-0.010284585,-0.058761753,0.013715849,0.06452548,-0.064338334,-0.040397268,-0.09259857,-0.07458632,-0.023193203,-0.008075357,0.027897729,0.006094076,-0.0070715896,-0.085279055,0.06893206,-0.09960677,0.023583634,-0.024879491,0.013294832,0.0027557095,0.0895708,0.036076073,0.005339174,-0.019336069,0.051792406,-0.027079001,0.093279615,-0.061185125,-0.104975946,-0.018778045,0.10612405,0.02448053,-0.036749262,0.030016871,-0.13381757,0.045421638,0.07958183,0.09370735,0.01621707,-0.014672462,0.04459625,-0.0028248923,-0.08703639,0.06924772,0.14720698,0.0003500935,-0.0032256797,0.017340897,0.046727665,-0.0064578457,-0.057071745,0.0052553224,-0.047258787,-0.009819151,-0.0023254533,0.07374281,0.011964708,0.058803476,-0.09111165,0.04503721,0.018689105,0.0879097,-0.07369872,0.03541851,-0.04913235,0.01047154,-0.10702874,0.00077523844,0.057198707,-0.016687194,-0.007894136,0.030714128,-0.11480436,-0.0006321377,0.039624907,-0.041268423,-0.013194368,-0.049457915,0.009706928,-0.067207895,-0.058483962,0.009045753,-0.037910715,0.05266815,-0.030301115,0.07917287,0.07235328,-0.10644845,-0.039053928,-0.016907757,-0.072510056,-2.1234877e-33,0.003755214,-0.057741143,0.04845066,-0.02576005,0.009774758,0.051977925,-0.02219341,-0.0046169865,0.025569534,0.039531384,0.032268796,0.03172135,0.115685076,-0.044346772,0.022626236,0.037023537,-0.020614244,0.15837392,0.011723522,-0.021498943,-0.0017186663,0.016026126,0.0047154077,0.0035618248,0.003973485,0.059067428,0.013293594,-0.05126158,0.005580206,0.050213546,0.042411212,-0.0038816312,-0.014403926,-0.022424819,-0.10737472,-0.03855259,-0.06750374,-0.022897556,0.03158579,0.03353816,-0.07484583,0.02287191,-0.00922455,0.10716386,0.08995649,0.022947984,-0.098826334,0.06352927,0.017465692,0.024469834,0.059907023,-0.03139695,-0.05721991,-0.032244947,-0.00024945688,0.0024573216,0.005132636,0.03298319,-0.050923828,-0.05795434,0.0055175517,0.026860261,-0.062919594,-0.0483358,0.12775476,0.07020257,-0.030254245,0.0046541165,-0.008186867,-0.07254151,0.070250474,-0.021209024,-0.042684246,-0.07747351,-0.009947645,0.020593392,-0.009890758,-0.04459758,0.020476548,0.008163103,0.014688488,-0.01686784,0.082059585,-0.04043528,0.010987384,-0.04137496,0.0055185487,0.04798189,0.019905936,0.024019523,-0.07977579,-0.027035518,-0.012621962,0.037697494,0.1132661,-2.6622885e-08,-0.00845281,-0.0046016825,-0.036946494,0.0006734468,0.05356924,-0.015521929,0.014000825,0.016877055,0.032429308,0.016850809,-0.014061288,0.032747835,-0.023467863,-0.02174166,0.09036709,-0.066304274,-0.047776856,0.0023690797,-0.042928193,-0.042278,0.02591236,-0.042019416,-0.02592604,0.026564112,0.021604948,-0.095458664,-0.0027451317,0.009273973,0.04092793,-0.023718746,-0.012920154,-0.029040745,-0.03690372,-0.0061397045,-0.031111632,0.04986762,-0.027733851,-0.05690591,-0.00012564646,0.08195354,-0.032300767,-0.11963586,-0.05858039,-0.0052695675,-0.051082477,0.05211203,-0.032949116,0.014582504,-0.041004144,0.025161281,-0.041145217,-0.099719234,0.011385835,0.024808668,-0.08367825,-0.013838579,0.0053813225,-0.0023505872,0.006523864,-0.07472648,-0.0077943136,-0.019215198,0.18131298,0.053260088 +4.2.3.176,Isolated from the fungus Neosartorya fischeri.,384,1.0000001,0.033300612,0.028240217,-0.16040501,-0.022230295,0.03576412,0.00027259928,-0.053958014,0.02937433,-0.01034643,-0.044246625,0.09163492,-0.049516216,-0.035393864,-0.001537628,-0.105743766,0.026629044,0.029208943,0.03091836,0.050728615,0.010599057,0.0004347057,0.07651433,0.058437616,0.036397114,-0.059601992,0.0058322228,0.018225398,0.022153419,-0.077057146,-0.035628486,-0.023736551,0.01384693,-0.024981312,-0.03470556,0.06766446,0.06657241,-0.03876155,0.021392746,0.10190572,0.06393007,-0.059794877,-0.07443874,0.009637649,0.012133097,-0.07209231,-0.013821819,-0.08772182,0.03793783,0.101130396,-0.02211401,-0.0070811496,-0.046495814,0.012995982,0.050410118,0.043069087,-0.022061616,0.076991305,-0.081404686,0.03463903,0.022329874,0.06512885,0.0072652493,0.018921796,-0.006266362,-0.074269824,0.037648533,0.047726344,-0.062304456,0.00063333224,-0.002278917,0.025681922,-0.004495228,0.011157948,-0.011102598,-0.0049747983,-0.0016996027,0.016535167,-0.032782666,0.06265816,0.058309995,-0.016341666,0.07462612,0.061330955,-0.033802014,-0.044251747,-0.023572948,0.038948677,0.009094516,0.0035381066,0.0066947443,0.010467623,0.103130616,0.01303846,-0.044528175,-0.026952548,-0.052346382,0.10010302,-0.0015473274,0.056225095,-0.008733528,0.0077685365,-0.079207666,-0.012069988,-0.10076512,-0.104148544,-0.0012183517,-0.005794514,-0.01920794,0.055715166,0.024585854,-0.0452826,0.017712533,-0.0023032958,-0.079445876,-0.028925335,0.01461512,0.130343,0.01479588,0.01639877,0.022576582,0.0037424762,0.03761825,0.0074231518,-0.0032160268,0.04095031,-0.0055266055,-0.00456165,-3.100623e-33,0.08398708,0.02325587,-0.03473975,-0.014815379,0.081072554,-0.0018931329,0.019011682,-0.04021251,-0.06987566,-0.009910333,-0.02630943,-0.031081721,-0.08587696,0.042904418,-0.0041196193,0.122310944,0.03615943,-0.016114706,-0.010868252,-0.013906876,-0.0113622695,0.0926089,0.0003575598,-0.03582307,0.011128977,0.062448885,-0.01736315,-0.0015994185,-0.008736525,-0.01944354,0.037890747,-0.078378804,-0.105302416,0.006535982,0.066585176,0.03030491,-0.0020717748,0.00035424053,-0.068932265,-0.012095874,0.059075523,0.050055504,0.053443413,-0.06983771,0.038082406,-0.077744156,-0.014496031,0.012394576,0.044819508,-0.046638105,-0.0063930913,0.046303358,-0.01675935,0.05641284,-0.058759026,-0.051958412,-0.0017871112,0.080673315,0.036778815,0.03059592,0.048191402,0.088929206,0.040770583,0.035915345,0.059969783,-0.030049508,-0.097624406,0.009150255,-0.012425297,-0.02903906,-0.04378137,-0.010699853,0.027797183,-0.021684809,0.029536525,-0.03393453,0.020228172,-0.03657301,-0.056891143,0.010411161,-0.066448644,-0.03651282,0.033032518,0.013895033,-0.13185608,0.052213207,-0.04907229,0.034979314,0.0020433604,0.020381138,-0.061927296,-0.07356673,-0.08619391,0.006293709,0.025363551,-1.1648994e-33,0.08237369,-0.01792459,0.031707745,-0.043655366,-0.03461948,0.10606097,-0.07797837,0.037328273,-0.09025356,0.0004949142,-0.014408251,0.013393655,0.047503334,0.008120035,0.047273,0.06922964,0.09305965,0.10921697,-0.021094717,-0.020344902,-0.012937009,0.04777905,-0.010044565,-0.050777074,0.021420253,-0.062634975,0.04929382,0.099392675,-0.09354232,-0.028789759,0.0586549,0.03248324,-0.03836094,-0.07063193,-0.07294942,0.0030871516,-0.07885065,-0.11796775,0.06804736,0.07146642,-0.018774688,-0.03299245,-0.010441496,0.07312162,-0.0011635593,0.035020478,-0.011908355,-0.00707812,0.038856816,0.031192724,0.027456965,-0.006654926,0.015200532,-0.11923782,0.06973104,-0.04252947,-0.052139554,0.034495156,0.07050544,-0.012398662,0.007489837,0.04127447,-0.062246867,0.0035409466,0.046222664,0.10368604,-0.057019416,-0.07503897,0.06863976,-0.03936838,0.040823974,0.083078735,-0.0029841466,0.12228606,0.01094565,0.010207059,0.013353111,-0.016713178,0.0038845213,0.02423533,0.033615503,-0.06250005,0.09648308,-0.050578672,0.024672708,0.032888953,0.056566544,-0.050992474,-0.08903694,-0.05607553,0.034860175,0.011575513,-0.13912514,0.009167048,0.004913574,-1.6554258e-08,0.15083314,-0.042829886,-0.011878205,-0.11550922,-0.05626801,-0.054004747,0.06976519,-0.0031698947,0.004856416,-0.0075880187,-0.01617016,0.019681497,0.037899397,0.07848811,0.021028068,-0.03087631,0.01626291,0.0041253096,-0.06007018,0.017250642,-0.07140808,-0.043145057,-0.013772489,-0.021254053,-0.04040137,-0.032703377,0.11865199,0.013320781,0.037712213,0.0030514246,-0.0024939862,0.062934645,-0.040146604,-0.06031571,-0.027306106,0.015995558,-0.068624645,-0.010487685,-0.024492212,0.0034017996,0.008844795,-0.014620851,-0.066549644,-0.020061381,-0.08915853,-0.032930322,-0.07178584,0.03451312,-0.018346906,-0.08306148,0.029207334,0.009351775,0.011840011,0.05009379,-0.05814443,-0.025469879,0.07457563,-0.036267728,0.0026280824,-0.048833884,-0.056725904,-0.10085708,0.035147928,-0.024685193 +4.2.3.177,"Isolated from the plant Cananga odorata var. fruticosa (ylang ylang). The enzyme forms roughly equal proportions of beta-thujene, sabinene, beta-pinene and alpha-terpinene see EC 4.2.3.109/EC 4.2.3.110 sabinene synthase, EC 4.2.3.120/EC 4.2.3.122 beta-pinene synthase, EC 4.2.3.115 alpha-terpinene synthase.",384,1.0,-0.01475972,-0.040491544,-0.12595867,0.021625467,0.061898593,0.06766313,-0.080518104,0.025636274,0.059992578,-0.037417635,0.10165836,-0.05098292,-0.0521661,0.023053693,-0.026198354,-0.019587751,-0.04055874,0.042322617,0.03724005,0.014722826,0.041293453,0.087757416,0.039337013,0.04605558,0.024339033,-0.04923928,-0.03459381,0.034788437,0.06431764,-0.139108,-0.050383132,0.0013327603,0.009607631,-0.007688048,-0.022659784,0.012972889,-0.033199262,-0.08043887,0.04254806,0.036251195,-0.035499047,-0.010046599,-0.04802156,-0.06993895,-0.019446885,-0.061446052,-0.04202589,0.033598613,0.05255518,-0.062136512,-0.029690944,-0.08378309,-0.03876386,0.041915663,0.0028043105,-0.06765316,0.0071167126,-0.046801995,-0.017688066,0.10948808,0.06532619,0.08926245,-0.005147866,-0.04023559,0.002801575,0.016031645,-0.058189802,0.05567288,0.09171596,-0.075575285,0.009408289,-0.0439603,-0.009600425,0.08144457,-0.0071219774,0.048967216,-0.008953357,0.040504746,-0.0008056594,-0.02168314,0.04559921,0.016139284,-0.05245844,0.0140968505,0.014291385,-0.016880345,-0.03960984,0.10450278,0.05054,-0.014988767,0.074100666,0.042898156,-0.056145668,-0.040982764,-0.004626575,0.040364064,0.054081764,0.047335,0.053457525,-0.028689766,-0.0016149865,-0.027937278,0.003683091,-0.13423082,-0.10450552,0.02404419,0.04483937,-0.06882531,0.06663968,-0.017929157,-0.049816445,-0.090189435,-0.005926829,0.04681758,-0.04983358,0.01624233,0.050152205,-0.034746595,-0.07727217,0.013365858,-0.02741795,-0.00043886589,0.10340946,0.04742302,0.025516067,0.0637359,-0.08713346,1.5808347e-33,0.07309532,0.11525818,-0.02505896,-0.01950377,0.044832043,-0.018248191,-0.018060716,-0.0052775727,-0.065714605,-0.02290662,-0.09888938,-0.009348977,-0.05482581,-0.029883614,0.044955548,-0.048638906,0.035785597,0.032543015,0.046599507,-0.07020913,-0.033922937,0.09725134,-0.0901699,0.0016543065,-0.01267744,-0.01565899,-0.013988648,0.01564081,0.028392358,-0.01834007,0.05287225,-0.07609128,-0.060128964,0.02710005,0.06773605,-0.043258734,-0.023694241,-0.01684851,-0.04357511,0.01238738,0.096337326,0.062018387,0.042738702,0.0016001648,0.03031579,0.018806774,-0.07907639,0.064530686,0.114341855,0.01352624,-0.028538255,0.026677856,0.0136080505,-0.0071568373,-0.06429807,0.020559471,-0.0069762873,-0.003599429,0.0697446,0.043009955,-0.04022488,0.06317977,0.0104442565,-0.04474148,-0.04034451,-0.021727985,-0.12823853,0.028684855,0.0054026023,0.01748187,-0.028180445,-0.059644204,0.024335254,-0.063613996,0.043257363,0.008328736,-0.100403816,-0.0077676037,-0.008887554,-0.056687437,-0.08425737,0.0119069405,-0.007105584,0.06075644,-0.02592322,0.032098383,0.0364056,0.072681636,-0.0017443387,0.046972528,0.092271976,-0.014478131,-0.006001388,-0.04594596,0.04360121,-1.7919985e-33,0.03975391,-0.012194867,0.04544211,-0.08397726,0.0029020857,0.03548604,-0.055341408,0.040137324,0.011288472,0.020082356,0.041349024,-0.072213635,0.08447988,-0.08711037,0.0146976225,0.024319218,0.04991424,0.117254846,-0.053790733,-0.03410363,-0.082503505,-0.03472941,0.029768784,0.013501959,-0.021556802,0.05120402,0.08834031,0.07060002,0.01488743,0.05280723,0.09507679,-0.018568512,-0.0751392,-0.020031855,-0.019104738,-0.055692624,-0.026719196,-0.05457738,0.034393806,0.023618242,0.015747957,0.025035374,0.0075908704,0.043295577,0.050092075,0.056378048,0.078501284,-0.092163295,0.013869074,-0.014775761,0.12070751,-0.018869916,0.02643058,0.016751217,-0.022438275,-0.015955178,0.007056139,0.055019304,-0.02869988,-0.054162942,0.06241659,-0.084676854,-0.059368044,-0.035055265,0.023895644,-0.019743191,-0.028600276,0.052455034,0.040565554,-0.027073996,0.059334777,-0.0033130557,0.0044553955,0.0559527,-0.045498937,0.013329816,-0.026231568,-0.13796155,-0.0044382378,-0.066345975,-0.04209296,-0.0053941673,-0.0488501,-0.078256704,0.011635379,-0.02331969,0.02817908,0.100787684,0.040887773,0.055379964,4.8295482e-05,0.026877532,-0.11255878,0.043466523,0.13166109,-4.2548095e-08,0.0069190287,-0.09340646,-0.01593704,0.046627596,0.0054625683,0.018724795,0.012333872,-2.2108728e-05,0.027330894,0.04253106,0.03373228,0.039552845,-0.03832219,0.0050333133,0.055635136,-0.03759718,0.021818804,0.09711895,-0.0065131285,-0.024054999,-0.020875363,0.027764492,-0.036777653,-0.014721257,-0.038887154,-0.049897984,-0.017033752,0.022685505,0.017982705,-0.07938265,0.03557107,0.011888103,-0.044777036,-0.031009361,-0.029345961,0.0073997756,0.0033930899,0.02302479,-0.038042963,0.04968541,0.0236952,-0.079421625,-0.074012265,0.03406405,-0.025603045,-0.053466458,0.036305267,0.023404887,0.013779736,-0.048202652,0.037061855,-0.03830485,0.05886655,-0.07609866,-0.042020388,-0.0012055286,-0.057329584,0.025334626,-0.061923932,-0.029420136,-0.013308588,-0.01772109,0.17333263,0.044334605 +4.2.3.178,Isolated from the fungus Aspergillus stellatus.,384,1.0,-0.056818374,0.044689346,-0.14240414,0.06165016,0.030614462,-0.0011172611,-0.05803975,0.017073229,0.020397678,-0.043731883,0.109130606,-0.058357272,-0.04744647,0.06198165,-0.105519734,0.022346381,0.07908317,-0.015627619,0.02424263,0.018620186,0.017053833,0.11869213,-0.0003015342,0.03122911,0.052661497,0.006496165,0.019990616,-0.0054563615,-0.028671231,-0.12765156,-0.04430855,-0.03210583,0.03025245,-0.0038366406,0.06242739,0.02097795,-0.03182788,-0.006884632,0.12457103,0.066130355,-0.03468788,-0.05016501,0.03881951,-0.0435578,-0.07320959,0.028374702,-0.09305936,0.05592897,0.101587795,-0.0037315001,-0.056064527,-0.01558131,0.012810145,-0.008693832,0.043153457,0.02633436,0.066514105,-0.08065918,-0.03418532,0.01853786,0.03135339,0.011543397,-0.0333287,0.020420609,-0.10460636,0.00014226748,-0.01280715,-0.031118222,0.014198576,-0.024430351,0.0107647665,-0.03153349,0.056545135,0.034218844,0.033114985,-0.0096811345,-0.004802873,-0.039457,0.057522587,0.033158455,0.05780506,0.037120722,0.042242043,0.02355999,-0.005426319,-0.016779142,0.029353622,0.07009472,0.00074397714,-0.00020555043,-0.016016467,0.06446373,-0.014357909,-0.0070385565,-0.04749598,0.036701534,0.10895636,0.04566939,0.02264735,-0.033033185,0.015880898,-0.059451636,0.079991065,-0.03642567,-0.0010767427,-0.010308554,-0.010932502,-0.030264094,0.11359186,-0.03281189,0.011081089,-0.019387065,-0.058834054,-0.081225865,0.061431114,-0.060312822,0.10445884,0.017002342,-0.036993317,-0.017652491,0.011501113,0.03160376,0.051471397,-0.042004168,0.030346038,0.08075471,-0.04245714,-1.4363156e-33,0.010118915,0.024657154,-0.047031187,0.01980547,0.04717097,-0.022157734,0.038555406,-0.047913466,-0.07709731,-0.06558041,-0.059047546,-0.014430379,-0.087854214,0.06692186,0.052882534,-0.0023744148,0.07224491,-0.050197914,0.0037728457,-0.025622133,0.05343337,0.07522652,-0.051939137,0.03495588,-0.01297293,-0.0083408,0.028019845,-0.026176484,0.025808012,-0.02914636,0.08065096,-0.02069715,-0.086140744,-0.004988478,0.087762035,0.050903395,-0.020246172,0.0020900983,-0.07910257,-0.0141097065,0.024265273,0.011034814,0.024258044,-0.06892838,-0.0016793536,-0.027359124,-0.06618766,0.0186361,0.06089491,-0.02259195,0.049734678,0.052456554,0.036566656,0.027340079,-0.012155906,-0.018048292,-0.030177103,0.058665995,0.028775143,0.04179294,0.005249115,0.058714,-0.027750941,0.044257633,0.021761658,-0.016114196,-0.03680547,0.008486315,-0.057330944,-0.04728837,0.0052669006,-0.0067857797,0.011762726,-0.08446593,-0.0031123513,-0.023929138,-0.04793457,0.020523429,-0.044335786,-0.07492547,-0.050545778,0.00033888395,0.08923009,0.017633362,-0.122811645,0.007748555,0.040304333,0.07579907,-0.021147514,0.035943326,-0.09355079,-0.037997484,-0.06754501,0.022531787,0.024625774,-9.675232e-34,0.12394169,-0.07093747,0.03473016,-0.0004303815,-0.06411166,0.1440363,0.013909223,0.08484555,-0.054434303,-0.011602692,-0.009077389,0.046679143,0.058802344,-0.029176857,0.045840032,0.07676835,-0.0071670027,0.13898154,-0.00594531,-0.033743743,-0.053660046,0.048641138,-0.020825863,-0.0046791,0.041714683,0.01755822,0.039460454,0.016674332,-0.08669323,-0.023309985,0.037131723,0.048062168,-0.005408543,-0.043597613,-0.10506709,0.06747343,-0.032968994,-0.06757344,-6.9126756e-05,0.028705608,-0.029173084,-0.020337122,-0.033359133,0.071412206,0.057697847,0.030620515,0.036820028,-0.0018572353,-0.021443542,0.003487743,0.0042293295,-0.023823103,0.013464498,-0.030915031,-0.021055633,-0.06586234,-0.0019770195,0.010297015,0.06963321,-0.03937159,-0.019590998,0.034932546,-0.060965125,0.030978583,0.084026515,0.027012652,-0.03969636,-0.07410533,0.029802408,-0.077533424,0.0497415,0.06713479,-0.033467714,0.072391465,0.0658545,-0.012855815,-0.039619178,0.019673932,0.0034028874,0.061566703,-0.0007600227,-0.085642874,0.08822425,0.013354617,-0.03933234,-0.13378836,0.123195656,-0.044408236,-0.10932789,-0.021506935,0.0063402336,0.06337789,-0.097589135,0.0036416596,0.10286258,-1.694708e-08,0.10888079,0.03982877,-0.01218827,-0.09327559,-0.0131339235,-0.023489064,0.045285255,-0.0060432083,0.05475121,0.01885883,-0.106434494,-0.02746323,0.0035279216,0.05603067,0.020236619,-0.06948917,-0.008462147,-0.01027692,0.0024861647,0.019041417,-0.038917553,-0.02003614,-0.010432828,-0.022079045,-0.07260163,-0.018071156,0.08556642,-0.039043892,0.039379343,-0.0055878195,-0.05797242,0.059747618,-0.018334826,-0.08457007,-0.013090646,0.003988593,-0.00092946563,-0.054497566,0.02272168,0.06342673,-0.034978043,-0.06658734,-0.030461635,-0.04151189,-0.10621369,-0.049524214,-0.031058662,-0.018908054,-0.015965814,-0.024435474,0.05639478,-0.009454612,0.017274246,-0.039838057,-0.09102974,-0.023013465,0.061462115,-0.03457464,-0.05758274,-0.027634747,-0.05534181,-0.043985885,0.08838356,0.06889745 +4.2.3.179,Isolated from the plant Xanthium strumarium (rough cocklebur).,384,1.0,0.05292758,-0.0065180054,-0.09280665,-0.03651698,0.027881848,0.06224439,-0.009978959,0.004721693,0.01670719,-0.08527701,0.079890475,-0.12851433,0.0068642455,-0.039858513,-0.043441545,0.0059469366,0.00997665,-0.06226953,0.023217129,0.04167676,-0.007723604,0.11800219,0.027730841,-0.005107325,-0.013369861,0.023051335,-0.06793806,-0.011765135,0.043969873,-0.09706481,-0.018535608,0.055781074,0.07286677,-0.013844932,0.038422175,0.034207527,-0.04338174,-0.013610868,0.062762775,0.042281874,0.07595728,0.030568808,0.06838102,-0.10195487,-0.11732138,0.061150704,-0.014192681,0.014550294,0.030848203,-0.027275657,0.042551376,-0.028546454,-0.04744222,0.040611565,0.08113309,0.042611774,0.041915655,-0.05738997,-0.040781464,-0.0032043976,0.05097436,0.10169092,0.01417937,-0.025274893,0.0005610056,-0.027588176,-0.12108119,-0.026497563,0.08623518,-0.04521644,0.0173226,-0.03520329,-0.035678804,0.0027522922,-0.09291974,0.042871792,0.006013575,-0.00797088,0.053469475,0.0027866925,-0.0796204,0.0105584115,0.006554295,-0.008366032,-0.028045993,0.0016838884,0.027936013,0.036986016,-0.01636299,0.0115725435,0.05632854,0.08573147,-0.027457926,-0.042152803,-0.00025760313,-0.03150594,0.105747454,-0.027340855,-0.02592266,0.025616858,0.008384342,-0.066708,0.03573465,-0.11253231,-0.09337365,-0.060898732,-0.041031428,-0.056046315,-0.016963879,-0.035338584,-0.097154915,-0.009681994,-0.061190676,-0.007527221,-0.014852072,-0.010667609,0.09929254,-0.0013410116,-0.056202862,-0.032133315,0.0174979,-0.002980379,0.06396639,-0.006540188,0.016661752,-0.044395898,-0.116142996,2.0238792e-34,0.03569435,-0.015579012,0.003927872,-0.09521617,0.050755907,-0.01913231,0.0020416651,0.024438584,0.017637148,0.03187573,1.2762806e-05,-0.050707616,-0.012156928,-0.047073755,0.010359365,-0.04841043,-0.0003206363,-0.012373571,0.054052323,-0.04677341,0.015556035,0.049691055,0.0023430588,0.022128474,-0.0298401,-0.021297626,0.05608028,-0.128484,0.013801051,0.0145244105,0.007965616,-0.038554445,-0.034799498,0.035750154,0.045142245,0.07793187,-0.06832368,-0.07508431,-0.021982873,0.04360907,0.09699175,-0.065248415,0.046565443,6.191195e-06,0.059481073,0.028497485,-0.071945935,-0.052553706,0.10638886,-0.029803623,0.042507082,-0.027119314,0.09414201,-0.0074066636,-0.032199014,-0.010520262,-0.026997428,0.03692011,-0.039347462,0.034074135,-0.012505197,0.045740258,-0.038405653,0.021313401,0.10150369,0.0043349005,-0.12842678,-0.05944135,-0.024251433,-0.04278194,-0.02236603,-0.06525908,0.1073413,-0.10926373,0.0074717025,0.025176974,-0.05685246,0.085092634,-0.0010414675,-0.023690473,0.04189464,0.06627479,0.026986046,-0.014434034,-0.07137332,0.06260902,0.009134995,0.090902194,0.038608465,0.13652506,0.029753484,-0.035708945,-0.076119035,-0.028694797,0.04288975,-8.664777e-34,-0.007842722,0.019117545,0.050126825,0.08082299,0.037633978,0.05438614,-0.050102156,0.037233047,-0.037117675,0.014451055,-0.046030916,0.0917917,0.053754896,-0.051399726,0.077924095,0.071567126,0.08920573,0.122392796,-0.0404849,-0.05955876,-0.06541019,0.028259486,0.004030102,-0.10759582,-0.023248656,0.008517324,0.040967908,-0.015629726,0.012512314,-0.061140943,-0.016394274,0.012557256,-0.06591581,-0.10224281,-0.056679197,-0.05937084,-0.040152095,-0.054455087,0.008291128,0.028961672,-0.022382269,0.051995493,0.054590523,0.05963767,0.11079924,0.036065474,-0.00096534926,-0.057133194,0.026274139,0.121366866,0.07264203,-0.037333705,0.03719746,-0.039767675,0.008938713,-0.031378113,-0.00034573366,0.020605989,0.0060899016,-0.0067348913,0.0012458176,-0.022627132,-0.061657693,0.025656763,0.030866282,-0.03125538,0.02960382,0.010025537,-0.04454157,-0.028636463,0.02566595,0.01869648,0.013909633,0.0413593,0.017675381,0.103157915,0.004452482,-0.026356546,0.009949562,-0.008010584,0.018260695,0.019498594,0.0217613,-0.0778692,0.08617849,-0.070856586,0.004164827,0.030615525,0.03488341,-0.0490109,-0.04185851,0.010236427,-0.03621115,-0.043877088,0.14982484,-1.9280527e-08,0.012641279,-0.019623913,-0.06814794,-0.0054095425,0.08279207,-0.02966636,0.008181619,-0.03958263,0.109788336,0.003743593,0.004490847,-0.07795797,-0.011193207,0.01966979,0.011443289,-0.013055286,0.04916294,0.01655028,-0.016545622,0.011644937,-0.08674722,0.024393816,0.00398123,-0.024306038,-0.05173875,-0.07923187,0.059472688,-0.014507971,0.008040618,0.04172533,0.009307291,0.088542245,-0.009164951,-0.040673666,-0.026948074,0.01933806,-0.0040895394,0.0057053287,0.079451025,-0.015187291,-0.011167009,-0.034155816,-0.00029596785,-0.00043430744,-0.067519024,-0.005224136,-0.027255781,-0.040686116,-0.03731562,-0.046272963,0.01324756,0.05328813,0.07017483,-0.0800575,-0.009740632,0.053428855,0.055509336,-0.043523803,-0.021184837,0.024680236,-0.07908554,-0.045944855,0.041889463,0.06717964 +4.2.3.180,"Isolated from the plant Pseudolarix amabilis (golden larch). The product is oxidized to pseudolaric acid B, a microtubule-destabilizing agent. ",384,0.99999994,-0.044261467,-0.01290142,-0.06630318,-0.018088263,0.063995905,0.0606837,-0.0036050277,0.07859049,0.015748845,0.029646901,0.07689478,0.054737736,0.0008168098,-0.02115754,-0.12054396,0.08466846,-0.06220489,0.03238259,0.007395418,0.033138596,0.087900676,0.020210022,-0.03211209,0.044293497,0.017570801,0.036128342,-0.036307875,0.029441051,0.056521688,-0.11340261,-0.025780946,-0.007139612,0.07307014,-0.05260248,0.014347924,0.022383686,-0.039864805,-0.06953074,0.038888045,-0.012071417,0.08061859,-0.023053117,-0.023739956,-0.08894465,-0.030081116,-0.02678877,-0.11769443,0.028489927,0.025721356,-0.0012510307,-0.09662082,-0.040161215,-0.03292542,0.074992165,-0.04986046,0.0037754064,-0.03972646,-0.03629648,0.0490528,0.08722142,0.087895855,0.06575046,0.019309416,0.016012356,-0.08285231,0.049826585,-0.048977993,-0.031147724,0.08522359,-0.017687326,0.057510596,-0.06640352,-0.03424255,0.014481423,-0.029208744,-0.031170575,-0.011410494,-0.07029674,0.0013510716,0.051985014,-0.0175063,-0.017736215,0.03549777,0.07026579,0.016031444,-0.011948563,0.0037000102,0.040995315,0.05715529,-0.052072827,0.009310149,0.08697402,-0.029868405,-0.04589342,0.01681824,0.062430322,0.062955916,-0.014749892,0.02063182,0.0043698573,0.0593876,0.031155514,-0.0055703986,-0.14172773,-0.06121301,-0.031229364,-0.064423054,-0.029658884,0.067798726,-0.054141935,-0.016679745,-0.036262814,-0.019267423,-0.043957867,-0.08845361,0.06018798,0.06876408,-0.059127852,-0.020286344,-0.07556879,0.023626195,-0.008745435,0.013980491,0.027351476,0.04011103,0.01938391,-0.098326236,4.237111e-34,0.0067505585,0.008551238,-0.011616085,-0.03850661,-0.019684827,-0.01447002,-0.0014057726,-0.0013340156,-0.02526541,-0.033841833,-0.057949368,0.033172086,-0.0135302115,0.019129766,0.011805369,-0.0412604,0.061429262,-0.06980274,0.1265192,-0.035544652,0.06580405,0.10175494,-0.05503598,0.0032871428,0.0017905537,-0.04647861,0.038250964,-0.063314274,0.071172886,0.013821589,0.07054624,-0.0037055286,-0.07861641,0.019697374,0.014005379,0.041390445,-0.1243611,-0.05281233,-0.020129962,0.1210594,0.094121814,0.034349497,0.06646194,0.028116398,0.06598188,-0.017058386,-0.02603805,0.0577258,0.10297979,-0.054868516,0.00030929592,0.032758653,0.0464634,-0.00989521,-0.07252025,0.014381352,-0.04464789,0.0028001168,-0.017030438,0.04061521,0.036394373,0.016633615,-0.03268255,0.06637128,0.03435911,-0.0075164074,-0.068430476,0.045566335,-0.056222815,-0.03813363,-0.037847374,-0.03932686,0.04693852,-0.03989124,0.031355657,0.00053074054,-0.04599578,0.03644207,-0.060045414,-0.037931673,-0.08824095,0.0104948655,-0.009094233,0.06364125,-0.056829132,-0.0015400888,0.0018699,0.081103034,0.0054456666,4.0640196e-05,0.07617247,-0.062964484,-0.07269125,0.062898986,-0.06340504,-9.773671e-34,0.020853277,-0.0678899,0.028580593,0.045423366,-0.009393015,0.0620655,-0.018532317,0.092969745,0.013738518,0.040499795,-0.003505697,0.051863436,0.06101763,-0.07710662,0.025126385,0.07248138,0.1295473,0.062311098,-0.075346164,-0.04395662,-0.06306425,0.081941985,0.034587543,0.017015148,0.040879916,0.0272133,0.08530812,0.0009103271,0.040607195,0.025933972,0.007653885,0.045808762,-0.04623343,-0.10432942,-0.065751426,0.036610715,-0.09086018,-0.09991985,0.036489528,0.02575207,0.02063376,0.011347891,-0.015164642,0.0450599,0.086658664,0.03937081,-0.014712047,-0.013676924,-0.041861415,0.005755866,-0.00041504932,0.013644678,-0.016858894,-0.026496448,0.025132092,-0.018256152,-0.07001595,0.043877218,-0.03115131,-0.05811871,0.047647655,0.0032441092,-0.039426766,-0.055672117,0.009346237,0.08624532,0.019964905,0.030971231,-0.07386639,-0.008663922,0.078105606,0.12686197,-0.0040378356,0.041205615,0.014904562,0.03857428,-0.04300548,-0.07010975,-0.0013323962,-0.061344523,0.05245622,-0.00062798103,0.024538059,-0.09154018,0.010126987,-0.017129418,-0.026610248,0.0859296,-0.014373794,0.027187388,0.009674417,-0.036768027,-0.09526006,0.049093887,0.08978574,-2.7819189e-08,0.098214574,0.013190297,-0.0103017,-0.026933784,-0.014027878,-0.024728725,0.011923094,-0.014998712,0.004887687,-0.041311353,-0.056693837,-0.009973215,-0.0071988646,7.818062e-06,0.017728683,0.0041213105,0.07622772,0.012522798,-0.037960142,-0.01928147,-0.08052431,-0.026195252,-0.042762317,0.010425399,-0.06452028,-0.045683183,0.07568859,-0.07672323,0.029701635,-0.046866696,-0.035977874,0.08097768,-0.057811465,-0.031859305,-0.039888736,0.057022408,0.037296634,-0.012459344,0.029846068,-0.03350479,0.014828513,-0.070469424,-0.058872372,0.002296962,-0.044325,-0.018648637,-0.03579414,-0.03781382,0.03926353,0.00762304,0.051756565,-0.054661784,0.031408813,-0.030597478,-0.092825286,-0.059035547,0.04086598,-0.021077186,-0.041456003,-0.05984932,-0.05443272,0.018410085,0.15648691,0.056819405 +4.2.3.181,Isolated from the bacteria Streptomyces pristinaespiralis and S. somaliensis.,384,0.99999994,-0.007615638,0.03632333,-0.16288456,0.03138386,-0.0662193,0.041743122,-0.011694591,0.0032261244,0.06712307,-0.036911577,0.06728706,-0.015575527,-0.0029059362,0.011426572,-0.029436337,-0.025363402,-0.01260124,-0.051682584,0.08141412,0.023744283,0.06376412,0.093474336,-0.0034920222,-0.07950721,0.020333195,0.10158031,0.0065064533,0.027251612,-0.0038721473,-0.045219947,0.041741382,-0.06815588,0.05960799,-0.03833509,0.12806252,0.055757415,-0.08194545,0.01678801,0.14229922,0.07557637,-0.01614045,-0.010473776,0.036804017,0.059684224,-0.09608857,0.037090816,0.032746755,0.11614116,0.016767848,-0.07821328,-0.04815733,-0.071754545,-0.02724008,0.055302296,0.054743707,-0.036238488,0.036343884,-0.055055622,-0.048902683,-0.07963754,0.04644338,0.0077482797,0.01354061,-0.04999475,-0.10617171,0.016863922,0.0380642,-0.018815933,0.08091019,-0.02237488,-0.043427862,0.041929398,0.012128161,0.10905645,0.00409369,0.03889397,0.012269389,-0.027162999,-0.04658018,0.0067239287,0.046749234,0.0033189233,-0.010861921,0.06710514,0.02070252,-0.047471073,0.034224655,0.054812644,0.028583976,-0.046314735,0.020994365,0.043033987,-0.023076568,-0.04891884,-0.08233186,-0.0039851675,-0.11062698,0.032241743,-0.0034293847,-0.010666714,-0.031107206,-0.021851182,0.06202949,-0.01717559,-0.03280285,0.033723835,-0.0036322358,0.011382728,0.09050524,-0.018282395,-0.06194304,0.017026579,-0.073692285,-0.04077869,0.022176674,-0.010666118,0.11631622,-0.011383403,-0.0102419155,-0.045024056,-0.053576272,0.049836453,0.10002548,-0.020737126,0.0026770856,0.03397135,-0.08249324,2.5908304e-34,-0.017891556,-0.01314669,0.032627147,-0.055200662,0.051250987,0.022776028,-0.0068419124,-0.04882808,-0.021404939,-0.049258325,-0.05364705,-0.109936334,-0.022304695,-0.000712759,0.037830412,0.05224168,0.012529825,0.038967934,0.034558356,-0.017605029,0.04662377,0.029591456,0.0052717244,-0.020926496,0.022906551,0.022065653,0.018362658,-0.0122399125,0.08994877,-0.03366616,0.093327425,-0.054581672,-0.09314321,-0.092109896,-0.0011150124,-0.013767994,-0.09996906,-0.018037697,0.024601685,-0.022683445,-0.016782876,0.045032494,0.06702491,0.03650928,0.041210603,0.013294052,-0.065049306,0.039519027,0.072985746,-0.0073679304,0.008266717,-0.042417105,0.04108999,-0.0095429765,-0.09368469,0.008421092,0.060692962,0.09283195,0.07127562,0.03947652,0.017465344,0.07998429,-0.017873388,-0.034877382,0.093418255,0.0032208043,-0.010528401,0.039528422,-0.041140422,0.041901294,-0.048494313,0.0065339794,-0.0315965,-0.04175336,-0.06290337,-0.047116965,-0.062203918,-0.056533705,0.04140133,0.0046639857,-0.10422945,-0.013302435,0.0188536,-0.020380637,-0.10938433,0.056064278,-0.04331732,0.011853079,0.006714881,0.047718924,-0.026063155,0.0019578426,-0.15125628,-0.0041444423,0.0029503675,-1.2669268e-33,0.0766982,-0.059894778,0.004367649,0.010593848,-0.029257987,0.10538014,-0.029617548,0.08120001,-0.09749927,-0.0142611135,0.02112969,0.032307837,0.02363661,-0.024700418,0.014471081,0.011287346,0.013265322,0.10128272,0.022617618,0.036216862,0.02895664,0.08597782,0.0022419072,-0.04661867,3.4362467e-05,-0.062042773,0.10213517,0.07699148,-0.056022406,-0.024788905,0.038046543,0.01644984,-0.068384245,-0.09738133,-0.11075886,-0.0054808934,-0.089903146,-0.039468765,0.08719807,0.0048067016,0.06861302,0.032925718,-0.018919904,0.07937498,0.015109801,0.03952486,-0.025285395,0.027568573,-0.019007487,0.042174265,-0.01451476,-0.006298515,-0.010370393,-0.02347689,0.03476461,-0.062330518,-0.07899235,-0.0066003995,0.039941274,-0.08945125,-0.04423827,0.013696189,-0.013761284,0.0030932503,0.07551992,0.05117537,-0.007654247,0.02280489,0.09327677,-0.038485978,-0.023931941,0.009094363,-0.0659287,-0.010974186,-0.029950308,0.077490486,-0.084951825,0.020202702,0.04889522,0.03463589,0.05296425,-0.075778246,0.0497838,-0.01269439,0.0067666774,0.0045375614,0.0727849,-0.019917104,-0.02148156,0.0834826,-0.045273237,0.03346921,0.014382292,0.008948451,-0.042207267,-2.2126144e-08,0.013097824,0.016615916,0.0804691,0.050872173,-0.008876152,-0.061139055,-0.049400777,-0.0003452937,0.033813402,0.0485898,-0.028858542,-0.09886135,0.00010865146,0.009998429,0.007396475,-0.005439525,-0.019934677,-0.0042253765,-0.004438902,-0.005274353,-0.08852663,-0.011289753,-0.0205216,0.058045436,0.034183722,-0.017400598,0.07989079,-0.08831762,0.02464341,-0.0007965447,0.023102256,-0.0060011214,-0.022392735,-0.022264061,-0.02138843,-0.016367953,-0.09293367,-0.039425988,0.023358379,0.00022916665,0.044192605,-0.054032173,-0.0020751965,0.01193458,-0.10794363,0.05031169,-0.002298126,-0.01725242,-0.08385446,-0.069753036,0.0426046,-0.013272986,0.01896546,0.057475988,-0.08553195,0.06397227,0.003275932,-0.013892113,-0.065462105,0.006787833,0.0031280594,-0.055163097,0.08548884,0.044109385 +4.2.3.182,Isolated from the bacterium Streptomyces pristinaespiralis.,384,0.99999994,0.0040896228,0.020451887,-0.17278223,0.019300742,-0.028672315,0.040237647,0.017801354,0.048461284,0.076487385,-0.06797783,0.054503,0.019179204,0.02372993,0.031086342,-0.04149331,-0.039236024,-0.017759081,-0.050258357,0.065893225,0.01131242,0.08034379,0.0932835,-0.010782759,-0.07029029,0.025707163,0.07634675,0.013098372,0.017516552,-0.004803292,-0.031984545,0.027585216,-0.07594389,0.0661623,-0.039179232,0.13032232,0.05220601,-0.0864356,0.014369063,0.15216652,0.0483077,-0.04685824,0.0014364619,-0.008007617,0.07323333,-0.0954399,0.035778668,0.036581177,0.10822499,0.039081845,-0.054957286,-0.019237746,-0.0596303,-0.032188762,0.0447914,0.015083496,-0.018695954,0.021965884,-0.047084983,-0.01980619,-0.054001033,0.052261632,0.026394587,0.012274849,-0.03843868,-0.091150336,0.013257951,0.048961934,-0.0136513915,0.11472472,-0.05414354,-0.035352252,0.048499815,0.006361545,0.10002962,0.00076015614,0.05169913,0.012050353,-0.032220136,-0.039781537,0.01782324,0.045618635,0.0014859823,-0.0028887377,0.07011485,0.015076155,-0.028526483,0.06790432,0.04115741,0.056486465,-0.011756979,-0.009558929,0.03793219,-0.00088395184,-0.049629718,-0.05811796,0.022287175,-0.11687945,0.0018333733,0.011609899,-0.0054907408,-0.03362494,0.009165072,0.076834746,-0.01854523,-0.04303893,0.034628063,-0.028457038,0.0051795854,0.06900881,-0.015889686,-0.025429502,0.020432232,-0.045386814,-0.040784582,0.031764317,0.008772094,0.14335875,-0.030789666,-0.02473982,-0.053449847,-0.03497835,0.041753937,0.08107968,-0.014612818,0.013110684,0.044544246,-0.08975972,1.658106e-33,-0.042021155,-0.016556256,0.07531291,-0.05149751,0.041975517,0.029918939,0.0006637215,-0.037508663,0.0002952736,-0.010852272,-0.061915427,-0.11434171,-0.0065309373,-0.026925988,0.026268022,0.05207021,0.036821976,0.058387637,0.041947193,-0.0024073326,0.021617917,0.07494445,0.011796922,-0.03374722,0.006477482,0.02779686,0.002908078,-0.009020656,0.12706879,-0.04290516,0.084002286,-0.06894893,-0.092219874,-0.028323008,0.030323606,-0.025737321,-0.088863865,-0.02540149,0.05412575,0.012825992,-0.012021923,0.038972694,0.0888309,0.037867427,0.048675414,0.0024267128,-0.06914699,0.034952503,0.0492831,-0.0002509719,-0.0120654525,-0.034112394,0.030363267,-0.02233463,-0.083517246,-0.014771485,0.04963675,0.10195339,0.07500069,0.024073396,0.02293256,0.100737296,-0.026279971,-0.004042693,0.0850593,0.010929378,-0.066307,0.0116239125,-0.052855466,0.03789409,-0.060094822,0.00043624773,-0.0406055,-0.055906463,-0.021010883,-0.03559488,-0.07759015,-0.05990567,0.033774786,-0.015170573,-0.12959832,-0.034748755,0.0021259973,-0.008291605,-0.102300435,0.08667904,-0.054614995,-0.014272348,0.028059218,0.07702239,-0.023783177,-0.0034384737,-0.16464408,0.010198636,0.0010528123,-1.9529114e-33,0.0828374,-0.06698026,0.014606895,0.014356734,-0.02451261,0.11347472,-0.07724422,0.062375195,-0.105350636,0.0034539502,0.0051513957,0.009214632,0.011320167,-0.025842402,0.0042971983,0.034619424,0.06446632,0.09069578,-0.015073175,0.056232307,0.0118287895,0.08994938,0.009280365,-0.041628953,0.0057302653,-0.055349886,0.08882936,0.05029639,-0.03029985,0.0032741684,0.03563667,0.008486794,-0.054865055,-0.10159853,-0.0820836,-0.0033902794,-0.061539773,-0.07518934,0.09659476,-0.027447252,0.014014412,0.009009761,0.006982168,0.08543628,0.018214373,0.047723882,-0.033254463,0.017048232,0.01148555,0.048959836,-0.019769337,-0.026202537,-0.00074894953,-0.026261145,0.01867622,-0.070783,-0.067388974,0.011203853,0.030203467,-0.07008438,0.00984686,-0.01494032,-0.04774503,-0.010428952,0.09204369,0.039549805,-0.019687995,0.04578757,0.044573974,-0.042639717,-0.012053573,-0.0065893265,-0.06631141,0.012755133,-0.012578141,0.06253173,-0.0353567,-0.0067911875,0.047178447,0.0310655,0.048290234,-0.07280046,0.02820662,-0.038885172,0.027589038,-0.012163711,0.04646139,-0.018160094,-0.019209113,0.080263644,-0.027526366,0.03657042,-0.010343963,0.008181882,-0.027966943,-1.958525e-08,0.037755452,-0.004919789,0.07433931,0.006563015,-0.024339233,-0.09187629,-0.029265389,-0.011100875,0.018695788,0.040549006,-0.04381108,-0.09832656,0.013450205,0.009122036,-0.003311106,-0.019740038,-0.022172567,0.00036073415,-0.015279581,-0.01989593,-0.10287707,-0.028115682,-0.040968277,0.046985567,0.028068388,-0.05070551,0.10042916,-0.08756659,0.031851448,-0.0030715913,0.0012168909,-0.01387717,-0.03773858,-0.046482053,-0.030589834,0.0038706432,-0.0743208,-0.018220667,0.027525028,-0.0046586953,0.021196123,-0.023314428,-0.01683335,0.009805996,-0.09682438,0.042461295,-0.008811767,-0.043308973,-0.07657608,-0.07286242,0.054103803,0.0035643522,0.02283739,0.07306341,-0.07883193,0.047224537,0.004224371,-0.03999413,-0.07624014,-0.001594155,-0.04112242,-0.026359342,0.1003929,0.02722162 +4.2.3.183,Isolated from the plant Isodon rubescens.,384,1.0,-0.10310384,0.010108483,-0.09930671,0.031506795,0.022152944,0.016730476,-0.011250593,0.010090639,0.006897417,0.010431714,0.15634033,-0.04479695,-0.05905895,-0.033299543,-0.05468503,-0.01034513,-0.019986918,0.016738838,0.021782836,0.03085524,0.064310305,0.09909145,-0.034308024,0.0028700293,-0.026927615,0.0124419015,0.0047009913,0.018317897,0.075582325,-0.08510656,-0.039808486,-0.05444616,0.07148781,-0.020561222,0.030732244,0.01809539,-0.01516848,-0.027976288,0.11238896,0.090017885,-0.036546815,0.005741543,0.05289167,-0.08408758,-0.06469296,-0.009657936,-0.005926792,0.009788032,0.09321976,-0.047239188,0.04044536,-0.017385148,-0.059522122,0.011004352,-0.025039451,-0.057954136,0.019185243,-0.0322955,-0.0061189164,0.09648293,0.08097919,0.031772643,-0.07193136,0.009973674,-0.068534344,0.0021908775,-0.014302628,0.04593516,0.09669149,-0.061134294,0.07118845,-0.043695644,0.0069789933,0.025340458,-0.017110914,0.007980678,-0.0086235665,-0.062327333,-0.07224143,0.009402884,-0.027311191,-0.0011948348,-0.014675761,0.06216648,0.0035776896,0.024119947,0.029544443,0.071295686,-0.0094487155,0.0051615904,-0.036129892,0.096306,-0.055097368,-0.029468134,-0.015821245,0.026654016,0.06531805,0.08313721,-0.036398947,-0.0020310446,-0.009661122,0.07851054,-0.072091684,-0.13898182,-0.048491035,0.018838229,-0.056547713,-0.05270566,0.03816939,0.0018435864,-0.051911857,0.064268954,-0.097376645,-0.019605422,-0.029748099,0.008720932,0.091534,-0.037274525,-0.04229551,-0.00084469316,-0.047972165,0.0063741636,0.055253513,0.010760278,0.011185038,-0.017432401,-0.002032567,-9.065438e-34,0.012602207,0.008028721,-0.023001555,0.0122717675,-0.020639427,0.046003267,-0.03332329,-0.00025823,-0.074953444,-0.019981762,-0.055291418,-0.05956801,-0.029692238,-0.02411097,0.032550726,0.025176995,0.0041852864,-0.006901724,0.08700177,-0.098772466,0.006746728,0.12189561,-0.053228453,0.00439382,-0.030025367,0.0016048787,0.032036517,-0.086170316,0.04058767,-0.011194537,0.059431586,-0.025350574,-0.017427024,-0.012805386,0.07663399,0.062184356,-0.04216379,-0.041971482,-0.041921083,0.0034412618,0.094736345,0.020909803,0.08394494,-0.023163216,0.034715585,0.02162838,-0.05620142,0.023120187,0.14907596,0.03597771,0.0005207467,0.03988845,0.06616098,0.0051218625,-0.05707773,-0.04434735,-0.009201776,0.019081758,-0.013065027,0.027748384,0.0329691,0.07782165,0.0130959535,0.0380843,0.061319362,0.06265627,-0.14961144,-0.016390083,0.008779403,-0.034652177,-0.052250914,-0.048465908,0.019239306,-0.043830283,-0.0122895185,-0.012864311,-0.020948265,0.038130052,-0.056986514,-0.007995666,-0.084823936,-0.04243285,0.013814349,0.04492113,-0.0356577,0.039585818,0.010686034,0.079037145,0.020123105,0.032257993,0.048737574,-0.010139914,-0.13539779,-0.044991527,-0.022099577,-1.6180087e-34,0.0578076,-0.04209657,0.030317813,-0.053301055,-0.043690864,0.06364903,-0.06485512,0.08367514,-0.03794966,0.001679052,0.0037568992,0.027429199,0.058224853,-0.03489814,-0.025326619,0.04988432,0.05507925,0.11553815,-0.028258782,0.031791396,-0.1241865,0.045795728,0.023514252,0.012520883,0.02444414,0.02686785,0.06664316,0.0071348897,-0.009475002,-0.019502977,0.088764496,0.03337089,-0.08997731,-0.044586737,-0.094401926,0.05988122,-0.06654017,-0.070318274,-0.018995358,0.004721651,-0.046166435,0.003594708,-0.012056116,0.044423074,0.090021186,0.012281562,0.0051720324,0.016595058,-0.11282146,0.09881374,0.06740256,0.013238951,0.03456601,-0.029821454,0.055698536,-0.08762605,-0.08612464,0.030408425,0.03728828,-0.07364041,0.06540065,-0.010569372,-0.099086784,0.01783983,0.044268593,0.092722826,-0.013403684,0.04555243,-0.06843713,-0.005646218,0.061173297,0.046369676,0.020089509,-0.0007702735,0.008939417,-0.00062220095,0.008474553,-0.047439743,-0.0591084,-0.020849684,-0.024818141,-0.041384935,-0.009104831,0.008664827,-0.006462283,-0.01585638,-0.0059095654,-0.036758743,0.029968647,-0.034050893,-0.026570257,0.053646073,-0.063858904,-0.015815515,0.11893296,-1.5072139e-08,0.08926042,0.01521348,0.012886856,0.026464397,-0.03887042,-0.011074796,0.013595915,0.046748847,-0.017977478,0.051633436,-0.015023838,0.04366216,0.012386206,-0.0037692161,0.025387002,-0.018726232,0.013566299,0.07397945,-0.00030665993,0.03799004,-0.121152885,-0.002536247,-0.026007995,-0.004928917,-0.047434993,-0.011476626,0.13097507,-0.033890978,0.06695481,-4.8782953e-05,0.12485843,-0.008441649,-0.035316527,-0.044904176,-0.015395833,0.04759265,-0.0260736,0.053831052,-0.016881594,-0.044389747,-0.021458901,-0.0341177,-0.068072416,0.040518392,-0.08768705,-0.018820357,-0.039511893,0.07510425,0.015024524,0.005053465,0.022502288,0.00012445278,0.044248786,-0.077648945,-0.07834473,-0.049428854,0.037924264,-0.013942519,-0.034205593,0.038050942,-0.06660605,-0.039199788,0.06831336,0.10961887 +4.2.3.184,Isolated from the liverwort Marchantia polymorpha.,384,1.0,0.067544796,-0.022037143,-0.11666592,-0.031171283,-0.005875599,0.07366841,-0.054942697,-0.012479123,-0.021842077,-0.007556975,0.020697135,-0.05777138,-0.06514329,-0.00020270726,-0.08452901,0.059956804,-0.0055835294,-0.0025082265,0.056171857,0.02514726,0.028627947,-0.03615703,-0.016562348,-0.020759728,0.01512414,0.01766899,-0.020040805,0.028327676,0.023873264,-0.09516215,-0.054237716,0.083375566,0.030916208,-0.053954713,0.03756308,0.09089748,0.0066853967,0.01917236,0.07247636,0.061676208,0.042146754,0.013596322,0.056483086,-0.059691045,-0.0185295,-0.004404962,-0.1153062,0.06007441,0.070394926,0.008914187,-0.0295107,-0.079511,0.018660761,0.036687505,0.011831586,-0.11719202,0.064661875,-0.021202868,0.033507463,-0.048350077,0.039166767,0.0010310462,0.04299513,-0.013959076,-0.035004772,-0.008457254,-0.070454,-0.051470906,0.10472501,-0.046903297,-0.03320938,0.027819226,0.0126206875,0.053907823,-0.065296195,0.0037111484,-0.053470854,-0.03200795,0.0561398,0.073875345,-0.06560114,0.06608657,0.03744182,0.005290201,-0.024656544,0.022751011,-0.0070917904,0.079830125,-0.055121098,-0.031951267,0.0071694013,0.044738967,0.042373464,-0.026614467,-0.035835672,-0.0044840225,0.028904546,-0.065763466,0.006203704,-0.04481433,0.06647468,-0.07861223,-0.028189223,-0.08433793,-0.05922673,-0.02351815,-0.13041869,-0.0006775738,0.08359529,-0.069076516,-0.088637546,0.05873716,0.011976385,0.021252891,-0.03755127,0.05588996,0.019733254,0.0297446,0.014163491,0.06251363,-0.036709037,0.016585184,0.054794624,-0.020869939,0.09719818,-0.071588196,-0.072522774,-6.060354e-34,0.10507025,0.011988597,0.02698195,-0.07857334,0.08230115,-0.044614993,0.07709784,-0.04322443,-0.029071035,-0.028597243,-0.06297212,-0.013503689,-0.023373086,0.018981116,0.019247364,0.031927623,0.022934387,-0.021694317,0.016742203,-0.04338138,-0.020095574,0.030246135,-0.009684091,0.00399285,0.015414794,0.044216115,0.06449844,-0.018209921,-0.0058079474,0.025047775,0.012661324,-0.03129341,-0.01724001,0.07931181,0.0372193,0.0040851412,-0.04478993,-0.098890655,-0.07227739,0.08438066,0.068596356,-0.022448149,0.04503342,-0.021081422,0.024422577,-0.047979265,-0.07511539,0.04280801,0.07640366,-0.0215298,0.0034375773,0.05075562,0.06344592,-0.014507891,-0.091053255,-0.025303306,-0.04113604,0.0444724,0.017044542,-0.005787551,0.020738859,0.048758063,-0.0067809178,0.057862762,-0.0051434673,-0.08082563,-0.11224714,-0.006408342,-0.063813716,-0.00088704185,-0.010147011,-0.059317175,-0.0115631595,-0.049920395,0.04560597,-0.012521033,-0.0077332794,-0.00950538,-0.0377629,0.010491012,5.7645604e-05,0.003125069,0.020228708,-0.025944583,-0.10942182,0.009070461,-0.0002754592,0.011749838,-0.0132805575,0.030581761,0.0013958401,-0.07068856,-0.11567706,0.035764422,0.060027923,-5.5279495e-34,0.030583035,-0.011538425,0.057849642,-0.0007372784,-0.038698137,0.040609468,-0.020578194,0.079786316,0.034441587,0.016539073,0.049008492,0.015169151,0.018243209,0.02919685,0.0065179556,0.07961019,0.14968905,0.09606124,-0.01209017,-0.0560623,-0.098047085,0.013999434,-0.021166945,-0.056678746,-0.018143395,5.8702255e-05,0.019862497,-0.033088733,-0.04753557,0.0034392131,0.048225727,0.050881375,-0.08223125,-0.06478526,-0.014589694,-0.057761963,-0.12517771,-0.07791935,0.09091792,0.093043245,0.009494627,-0.014911463,0.03312597,0.05222519,0.10300561,-0.009703887,-0.020667236,-0.048406728,0.08747856,0.03798257,0.00040766847,0.032807782,0.080180235,0.030360311,0.05736855,-0.014895514,-0.015222442,0.04641737,-0.009011672,-0.017382445,-0.051977616,-0.0005218074,-0.01358837,-0.017634122,0.06831475,0.14505157,-0.011543318,-0.049552962,0.02763775,-0.02646276,0.056567565,0.010805879,-0.004659826,0.15450127,-0.025978548,-0.055277117,-0.0421811,0.023502126,-0.0083984155,0.016969789,0.0652976,-0.04506133,0.08535597,-0.036364287,0.037225734,-0.07921673,0.003927067,0.03005941,-0.02309085,-0.019836143,0.058379143,0.04334755,-0.1003129,-0.056047305,0.06395828,-1.8092686e-08,0.06407209,-0.08007285,-0.065635145,-0.017989893,-0.028148001,-0.020436123,0.024134891,-0.01919241,0.025095984,-0.031671498,0.011805804,-0.0055287858,0.012933671,-0.016796926,0.075705126,0.00637244,0.06225701,-0.026763353,0.0023622008,0.012707084,-0.092948,-0.052979674,0.03280911,-0.014720351,-0.053449646,-0.013878012,0.11812682,-0.008351532,0.08021191,0.036456134,-0.054119762,0.048398573,-0.052069418,-0.013872523,-0.078430414,0.10198662,0.009106109,0.01732797,0.060691096,0.007490395,0.055637587,-0.03270592,-0.04294661,-0.010201787,-0.022994116,-0.05025981,-0.065077394,-0.011337181,-0.021262886,-0.096008345,-0.012544579,-0.008686257,0.05508551,0.021108374,-0.033368427,0.051643837,0.061581504,-0.08535719,-0.024772748,-0.02344519,-0.052092917,-0.019613754,0.12187461,0.033284087 +4.2.3.185,Isolated from the plant Isodon rubescens and several species of Aconitum as well as species of Streptomyces.,384,0.99999994,-0.0656274,-0.041367937,-0.15327929,0.046174362,-0.07567856,0.05963032,-0.04967778,0.03001402,0.035403892,-0.039271206,0.1367623,-0.08089219,-0.0007412472,-0.003299355,-0.07249436,-0.039244197,0.023045981,-0.003719678,0.07493094,-0.0073771356,0.057418153,0.09799695,-0.0077590253,-0.038177438,0.034522995,-0.030478776,-0.054055918,-0.0051234835,-0.008748588,-0.06670687,-0.026499623,-0.054875363,0.110347666,-0.017999263,0.10725024,0.04932024,-0.0319333,-0.0084807975,0.17525423,0.08697863,-0.057366,0.015920887,0.05754196,0.008789738,-0.05009098,0.011128195,0.0021455067,0.0488292,0.07488232,-0.04647585,-0.020030666,-0.0060657132,-0.0938211,0.04303879,-0.02332946,-0.043289077,0.069761164,-0.008160754,-0.017845845,0.016074643,0.084378205,-0.034455635,-0.029286114,-0.016261127,-0.13906755,0.029007751,-0.012204119,0.010057736,0.114564344,-0.013289856,0.032347325,-0.033920858,0.0025329604,0.057106383,0.0007246686,-0.0068490407,-0.043491196,-0.05860356,-0.103491746,0.03024181,0.024485398,0.011151795,-0.023511106,0.04799558,-0.00051551056,-0.04932687,0.045989774,0.06306244,-0.014643835,0.034599897,-0.031797722,0.11333329,-0.051248033,-0.07208239,-0.015662467,-0.025513718,-0.011622483,0.072622545,-0.03508498,-0.01994995,-0.008462427,0.030369373,-0.015071397,-0.067789644,-0.0032108852,0.029576158,-0.097659424,-0.08657357,0.082044676,-0.028714105,-0.04077978,0.045011573,-0.14615248,-0.08193304,0.036159676,0.0026903863,0.12323552,-0.045624085,-0.021250373,-0.009292463,-0.03183209,0.0051584197,0.059284974,-0.013037523,0.057402544,-0.038482312,-0.042204242,-3.9567717e-35,-0.019734707,0.032399848,-0.009962238,-0.056317385,0.019140994,0.036155865,-0.04136915,0.008805343,-0.038080577,-0.03782232,-0.026961055,-0.05571783,0.011724706,-0.016149597,0.029153883,0.011422854,0.011573331,0.02666329,0.06731445,-0.09157249,0.020933207,0.07375883,-0.033976946,0.056883916,-0.043632984,-0.032909274,0.0013436599,-0.027034855,0.054775625,-0.03582688,0.042814337,-0.02938966,-0.042922247,-0.014925225,0.05232179,0.024810508,-0.07262493,-0.05265964,0.02528088,0.011285043,0.021880634,0.047327362,0.079321906,-0.0045215264,0.044116583,-0.025978817,-0.06847562,0.01631684,0.13115306,0.07701706,-0.018057063,-0.01869249,0.08398674,0.022516817,-0.0850947,-0.03990791,-0.038704805,0.094012216,0.031515297,0.01879991,0.049848463,0.03144658,0.023391975,-0.0072646355,0.01837159,0.07709262,-0.10330434,0.017482875,0.016894225,0.015406034,-0.03541724,-0.07618642,-0.020227382,-0.052106604,0.010209315,0.001077221,-0.0395423,0.023672698,-0.030203052,-0.011263846,-0.11436776,-0.018591711,0.045504887,-0.023290567,-0.04813612,0.083075374,-0.016861012,0.05402228,0.057412054,0.03574578,-0.00971893,0.025324142,-0.1357581,-0.006233122,0.023504404,-1.5874243e-33,0.10696313,-0.03573407,0.016656961,-0.049223848,-0.07192803,0.083756775,-0.097648054,0.07470854,-0.056491505,-0.015318118,0.011623649,0.018205836,0.017308999,-0.050907034,-0.0126007935,0.026649456,0.035310496,0.10262168,0.022061761,0.09316808,-0.07910822,0.016307939,0.0045172763,-0.030890997,0.032411646,-0.0046641342,0.04420261,-0.018478839,0.040976863,-0.012423863,0.06318006,0.014980446,-0.06799819,-0.054544296,-0.09169138,0.06473591,-0.057851236,-0.04118817,0.032470506,0.06523678,0.028357089,0.016416801,0.028846895,0.061501753,0.09019277,-0.001805568,0.0013460953,0.06346374,-0.08670089,0.06677721,0.047001943,0.007629676,0.020833852,-0.040382773,0.022821514,-0.035412177,-0.07635004,0.03237677,0.0070172213,-0.084543824,0.04584154,-0.035718407,-0.08045015,0.019556655,0.07506424,0.055443667,-0.03167159,0.029618725,-0.030489136,0.02754746,0.0026550726,0.0355641,-0.03247375,-0.016911637,0.011442654,0.012720794,0.0016534097,-0.016149808,-0.0686404,0.019142201,0.0065783397,-0.0028709257,0.03975329,0.00896226,-0.056239214,-0.0034409843,0.011674618,-0.057452198,0.014340845,0.039057594,-0.057032097,0.06722614,-0.002692116,-0.02163824,0.05223573,-2.2556806e-08,0.102417655,0.045743678,0.065528356,0.046402503,0.015249713,-0.045824517,-0.020899978,-0.0065821838,-0.03611905,0.05305371,-0.03943145,-0.026143322,0.022453042,-0.023488559,-0.011824438,-0.008844259,-0.0245441,0.016490774,0.028806517,0.07467667,-0.12627897,-0.02815844,-0.01942981,0.031858344,-0.024819005,0.0006115367,0.100640595,-0.06530495,0.019947156,0.03034387,0.10667669,-0.018804263,-0.028328804,-0.06543582,0.02444779,-0.0005634396,-0.030107414,-0.021463277,-0.012922454,-0.047881547,0.00064383773,-0.0470752,-0.040783927,0.06385542,-0.1076662,-0.008466012,-0.01927984,-0.016365793,-0.009806078,-0.02124976,0.04106845,0.020016177,0.0029872647,-0.030718897,-0.03336687,0.021346653,0.051209748,-0.03721635,-0.03979431,0.035324946,-0.05420926,-0.044000972,0.07709898,0.04707963 +4.2.3.186,Isolated from the plant Salvia miltiorrhiza (red sage).,384,0.99999994,0.005038036,0.0027606578,-0.11027324,0.06376913,0.100927815,0.082174815,-0.004131799,0.019106809,0.029613173,-0.03987741,0.0833446,0.01988271,-0.051514134,-0.029724035,-0.00949737,0.018019475,0.007738779,-0.02403793,-0.046837486,0.020558551,0.08425599,0.020625671,-0.0009980407,0.0038157927,0.039477743,-0.017240705,-0.02797322,0.04860025,-0.021369623,-0.10884606,0.06686651,-0.03578425,0.11318007,-0.09767802,0.05734095,0.04561809,0.0041839457,-0.020542853,0.047749072,0.0431883,-0.021383226,-0.06709047,0.022626529,-0.012201669,-0.003791828,-0.02730405,-0.016127603,0.027111214,0.10128416,-0.046705652,-0.04194403,-0.07058039,-0.03562774,0.09263547,0.001935659,-6.658054e-05,-0.00049220654,-0.029347183,0.036546644,0.021850118,0.025682,0.025599582,-0.015151581,-0.0559913,-0.07088819,0.0055924817,-0.025186481,-0.07042528,0.0974046,-0.095295765,0.020416034,-0.052777383,-0.04626446,0.054875746,-0.057456914,-0.005660075,0.010748344,0.022135057,0.043658126,0.02763022,-0.009981577,0.07706328,0.01514911,0.010859089,0.060023367,0.023291254,0.019044818,0.053300925,0.02358664,-0.06254176,-0.043819427,0.036852933,-0.0116937235,0.0029223838,-0.017539483,0.045949657,0.036149696,-0.029664505,0.011020161,0.0404489,0.05632627,-0.012710941,-0.024831345,-0.111350246,-0.059256002,0.08597843,-0.075154744,-0.013466461,0.020323252,-0.07612723,-0.039555658,0.00023450507,-0.042402204,-0.008178548,0.017905775,0.012229317,0.08556174,-0.024921834,-0.07600745,-0.03860981,0.016202984,-0.026614945,0.10972228,-0.018119697,0.03865002,0.0137002645,-0.075567335,1.3521564e-33,0.041590203,-0.06440285,-0.000723239,0.020294484,-0.025335584,0.0091776,0.0025269492,0.06956109,-0.020552896,-0.063655265,-0.04231517,-0.093899034,-0.019217052,-0.033848993,0.005920011,-0.023217335,0.07642397,-0.048459552,0.07309276,-0.016790759,-0.06933054,0.08990834,-0.030023882,-0.056218576,-0.0475496,-0.008749896,0.027005231,-0.07465858,0.107338816,0.013371272,0.059199158,-0.059476085,-0.024238927,0.017942397,0.011952796,0.008323185,-0.113145165,-0.05376326,-0.02437439,0.050938286,-0.0060671805,0.05675775,0.042176645,0.05467781,0.065009564,0.027054165,-0.07088844,-0.039541084,0.12767245,-0.032258026,-0.047979593,0.06321604,0.051675033,0.042905945,-0.055828013,-0.030648764,0.0055797473,0.057037845,-0.017063005,0.014725783,-0.025076292,0.06794533,-0.03623191,0.0072850445,0.039383493,0.015805595,-0.09337498,0.0997954,-0.040765695,0.03203012,0.0013055629,0.02910154,-0.018788345,-0.042000417,-0.045622785,-0.048280437,0.008857143,0.036665317,-0.005165348,-0.060206544,-0.043761965,0.045541346,0.030537479,0.118181214,-0.10282453,0.0040917667,-0.059188865,0.039272767,-0.0072049536,-0.011364887,0.05819952,0.024857465,-0.074934475,-0.049319327,-0.024368847,-2.381261e-34,0.10042447,0.013769101,-0.01388285,0.00062854146,-0.034150906,0.10773123,-0.03193245,0.063396834,-0.058653515,0.03568795,-0.02183758,-0.034128953,0.032611366,-0.07057399,0.04049217,0.092094384,0.03924669,0.13579242,-0.06877215,-0.00074603414,-0.10931103,0.05548638,0.021779722,-0.044205252,0.0020326679,0.018382374,0.04389116,0.009972911,0.006570776,-0.0015399235,0.09063166,-0.020237464,-0.13413717,-0.12764542,-0.06965951,-0.0036120084,-0.06000159,-0.11419608,0.0057217027,0.048216525,0.026169501,0.02688673,0.038371377,0.0052743526,0.08009902,0.05542584,-0.04278468,0.03221999,-0.040505383,0.02921752,0.052491426,-0.061331183,0.006724499,-0.020977627,0.030979645,-0.07326699,-0.0041635963,0.059765585,-0.0006672158,-0.048185244,0.028388886,0.03736096,-0.06706973,0.013902839,0.029817633,0.06688433,0.031448588,0.061321735,-0.07188799,0.05243662,0.07289977,0.03214912,0.022484802,0.09243243,0.02973346,0.08049535,0.012650141,-0.034910135,0.010999297,0.028558815,0.067035064,-0.06730634,0.037287563,-0.09052117,0.0020506242,-0.050415184,0.022919754,-0.014910171,0.0055996915,-0.010409768,0.008965256,0.013585225,-0.05898643,0.036055163,0.13066886,-1.6635502e-08,0.09365642,-0.06934354,-0.06326471,-0.018459631,-0.015971866,-0.030604096,0.017261742,0.03370626,-0.0020883186,0.06705334,-0.023773108,0.00339151,0.03280169,-0.018599927,-0.019226994,-0.016791921,0.10977456,0.05637882,0.01307069,0.03355613,-0.058733515,0.01598522,-0.015553067,-0.0029662105,-0.047480483,-0.09973601,0.093982264,0.0065954416,0.087783195,-0.028627852,0.040732723,0.01619099,-0.00058286905,-0.044363327,-0.015884615,0.08489934,-0.04141662,0.00015667893,0.041870523,-0.025185749,-0.011384888,-0.043018624,0.0077669625,-0.009978932,-0.022072272,-0.05384996,-0.056654606,-0.016928852,-0.05003879,-0.072826274,0.01882767,-0.018662067,0.04825597,0.0040597003,-0.1170565,-0.044321127,0.027538864,-0.03835798,-0.006504742,-0.06721534,-0.021414738,0.00048218176,0.025387205,0.09545295 +4.2.3.187,"Isolated from the bacterium Kitasatospora setae. The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. See also EC 4.2.3.174 (2E,6E)-hedycaryol synthase.",384,0.99999994,-0.0646912,0.005371606,-0.13884917,-0.034059655,0.0060465545,0.033681713,-0.08076471,0.0696737,0.025308643,-0.014448105,0.06745431,-0.0793073,-0.04114981,-0.027376493,-0.04108296,-0.02054017,-0.0783976,0.028315281,0.08202257,-0.019743077,0.024110284,0.071101725,0.017547956,-0.0032262318,0.04695213,0.058342,0.057677634,0.0011946637,0.02302496,-0.0739948,-0.025203476,0.06365765,0.026880773,-0.1091719,0.11264912,0.058290705,0.014542726,-0.032690182,0.08731575,0.03778518,0.020319574,0.021830158,0.081304245,-0.033786356,-0.076641925,0.041128166,0.02535337,0.08614314,0.025402239,-0.07629414,-0.018607864,-0.038613115,-0.052442443,0.012793267,-0.018248161,-0.019521255,-0.0107438,-0.012088814,0.042167053,0.013235597,0.04812232,0.051140036,-0.0024876883,-0.026559778,-0.031635683,-0.035416506,0.026680326,-0.047102157,0.081274,-0.0247346,-0.0815161,-0.02990303,0.02652578,0.080307245,-0.014235984,0.063118875,0.052873414,-0.018433528,0.014477199,-0.06992594,0.0154084405,0.009244078,-0.01864814,-0.0071510663,-0.047012176,0.023044256,-0.040953126,0.08517007,0.09879501,-0.006527117,-0.008907698,-0.01904745,-0.0139896665,-0.060457107,-0.08606954,0.032678533,0.03388453,0.035628106,0.08070107,-0.014742017,0.081176214,-0.01644655,0.025485123,-0.07415615,-0.043222442,0.024186667,-0.03721739,0.020692421,0.019939633,-0.022036623,-0.032326303,0.025150828,0.026856177,-0.06423836,-0.049797326,0.013324278,0.03485368,-0.029811027,-0.046485517,-0.011141515,-0.071615,-0.027842842,0.0369564,0.06586606,0.00396243,0.002154819,-0.13553636,4.4445915e-33,0.07680689,0.026658824,0.072546996,-0.0053920597,-0.0016335441,-0.026633395,0.040196817,-0.029513586,-0.09158411,-0.025213508,-0.08136894,-0.044216935,0.00516127,-0.02699883,-0.06921567,-0.007526669,0.014032364,0.006977349,0.018910103,-0.08961001,-0.0319498,0.10436244,-0.008595292,-0.0010433759,0.048821922,0.06911793,-0.0056629702,-0.0737884,0.12931783,0.002224072,0.010027485,-0.06932549,-0.041013204,-0.029892864,0.083998136,-0.031999577,-0.09688867,-0.069943614,-0.0052676992,0.058095228,0.046275612,0.043758053,0.0023050255,-0.03405528,0.06582768,-0.039041176,-0.061089355,0.09884229,0.055896703,-0.0015652344,-0.0028111534,-0.012859884,0.058939118,-0.03670893,-0.09310984,-0.0039614853,-0.022093717,0.019025004,0.05218455,0.03383062,0.03426662,0.090761416,-0.047662225,-0.014155836,0.029312097,0.019355604,-0.09114413,-0.042844854,-0.039291527,0.0657048,-0.040774863,-0.0802628,0.0022878726,0.060026973,0.0360264,-0.013565298,-0.063218005,-0.03249307,-0.0101854745,-0.015876448,-0.021459829,0.007861785,-0.027286675,-0.026451744,-0.042164836,0.008505744,0.012302125,0.012677096,-0.06570899,0.114690796,-0.0036910223,-0.08942784,-0.06246439,0.008751529,-0.04611422,-5.176035e-33,0.06185798,-0.019917967,-0.017804755,-0.11570369,-0.034922227,0.00058927765,-0.0041536074,0.013057022,-0.024951724,-0.0096454555,0.0070052017,-0.008313556,0.06706654,-0.0868084,-0.064227454,-0.00899044,0.06827605,0.08488523,-0.0037197603,0.043641336,-0.025050716,0.009888062,0.030381205,0.0075334553,-0.04251753,-0.04054349,0.030769458,0.10741027,-0.036934875,0.050844878,-0.031416282,0.0049495515,-0.026412306,-0.08425326,-0.072447255,0.0004381905,-0.07679765,-0.052874617,0.03741188,0.007996311,-0.04876865,0.074722424,-0.045526832,0.08749822,0.07592835,0.09830247,-0.04370887,0.026191683,-0.025397565,0.008468303,0.0043958607,-0.0007221831,0.036446907,-0.015210872,0.03444394,-0.039309327,0.020667473,0.05326192,0.021520726,-0.06518993,-0.0147452615,-0.118305065,-0.00078028155,-0.043458,0.1265776,0.17795883,-0.020355528,0.07575443,-0.020924868,-0.050900448,0.0957606,0.014253868,0.014899995,0.02061186,-0.044527303,0.011552035,-0.016043589,-0.105239525,0.024717834,-0.089571066,-0.018680826,-0.08749695,0.041117538,-0.006434136,0.021039939,-0.017031642,0.077828825,0.038791925,0.022902444,0.08531025,0.00027398465,0.017363854,0.016779527,0.07309887,0.105592325,-3.860685e-08,0.034641422,0.00813471,0.04899013,0.025043448,-0.011634238,0.057457592,0.011629078,0.06269458,0.04354919,-0.024951715,-0.020318106,0.0061384216,0.11013349,-0.009999925,0.0958817,0.06458221,-0.03691018,0.039669544,-0.055855736,-0.008820926,-0.015624165,0.011989445,0.020530384,0.048019215,0.022368055,-0.034344677,0.07319251,-0.012592064,-0.013880172,-0.070312716,0.0075489185,-0.02380751,-0.03649666,-0.023804784,-0.03420351,0.008077206,-0.08582761,-0.00014909012,-0.0224831,0.013486172,-0.0026740616,0.017887477,-0.086668186,0.059379667,-0.016739074,0.025264192,0.009570274,0.04473684,-0.010443066,-0.046859585,0.017663905,0.0015850579,0.030045828,-0.093166195,-0.091955945,-0.035881687,-0.05548696,0.011062518,-0.058557216,-0.019823806,-0.05257135,-0.0051121167,0.11793414,0.029138703 +4.2.3.188,Isolated from the bacterium Bacillus clausii. The enzyme acts on a range of polyprenyl diphosphates.,384,1.0,-0.045908246,-0.041801147,-0.04376418,-0.011362972,0.0020524517,0.02960797,-0.043202896,0.019939603,0.05736284,-0.050261337,0.01705736,-0.073731124,0.015074861,0.018106608,-0.03386724,-0.003555125,-0.055943247,-0.015724204,0.031526968,0.026537055,0.10052825,0.07274115,-0.07003503,-0.03567274,0.0066095483,0.044872828,0.09449294,-0.047318295,0.007055804,-0.0007770652,-0.10306203,-0.007509251,0.057604454,-0.063775845,0.10694595,0.11288355,-0.03171646,0.007767718,0.060773574,0.016187798,0.056744188,-0.0022336342,0.041826066,-0.060076877,-0.08548878,0.06940782,0.013889815,0.04720346,0.06406808,-0.057264682,-0.07264946,-0.01293381,0.017346997,0.040525064,0.01032376,-0.045070194,-0.009408774,-0.018381793,-0.025578331,-0.021022473,0.03032283,0.050375924,0.029180368,0.0010252257,0.017006021,-0.031664573,0.025102682,-0.02310923,0.05329029,-0.0754066,-0.07006382,0.011150617,0.025316833,0.018798405,-0.0037739272,-0.010294784,-0.003923756,-0.04045544,0.0632088,-0.03940315,0.027084237,-0.054858103,0.017889876,0.10236548,0.006945586,-0.025519954,0.05072907,0.04117284,0.059471272,0.043131504,-0.017541176,0.0020969035,-0.010382515,-0.099063896,-0.03929548,-0.0006475726,-0.03745745,0.03369236,0.021478135,-0.026046187,-0.0011350935,7.3650335e-06,-0.0069067855,-0.07827572,-0.04695208,0.012768675,-0.038202174,-0.020857895,0.101500005,-0.0061260494,0.006070125,0.054244682,0.033606183,-0.10142402,0.007697481,0.037106607,0.04380423,-0.05485599,-0.05368229,-0.018126126,-0.007208242,0.0106646465,0.038827073,0.06766253,-0.04538798,0.017619291,-0.117699936,5.43467e-35,0.053374823,0.0076706074,0.07718767,-0.068636045,-0.025772804,-0.052984685,0.007885281,-0.009092212,-0.10245501,-0.011732988,-0.02359688,-0.08067999,0.031579707,0.036049046,0.038417522,0.012018763,-0.007691711,-0.03253779,0.08989188,-0.03755012,0.008445582,0.09488369,-0.0020435615,0.045325812,0.005302272,0.002377535,0.0012458345,0.018506477,0.05186193,-0.023010721,0.10772875,-0.13547722,-0.117224015,-0.032282896,0.07552942,0.0007161155,-0.08082226,-0.026944147,-0.04506154,0.022871504,0.057849884,0.024673589,0.08022815,-0.027919115,0.049474906,-0.030920405,-0.077578716,0.06653357,0.051206663,0.022676032,0.026735915,-0.024983387,0.056787375,-0.06920354,-0.04877296,0.0041596647,0.0055980375,0.03808059,0.005344127,0.06617113,0.013811134,0.031100545,-0.06990454,0.00775784,0.013048722,0.0509392,-0.031933412,-0.031709068,-0.007792003,0.048978988,-0.04226393,-0.0133301895,0.02643542,-0.033471115,-0.024844328,-0.007966176,-0.057488024,-0.052140675,0.011251857,0.0046326285,-0.039159678,-0.084376216,0.06089723,-0.016869005,-0.12456932,-0.015746662,-0.010421366,-0.003515689,-0.03284179,0.08824479,0.044855237,-0.11318573,-0.08300597,0.09015113,-0.054148983,-1.992215e-33,0.112065494,-0.05943374,0.06442802,-0.11090394,-0.10999819,0.059226207,0.05454439,0.038892157,-0.035179302,-0.0050697974,-0.006691891,0.03263036,0.130097,0.0032221794,-0.029105665,0.13621598,0.05142154,0.1141138,0.013453083,0.018194228,-0.0094119,0.10215573,0.03574575,-0.007982562,-0.005990409,0.009830482,0.0876128,0.09781706,-0.06996665,-0.01359808,0.0015743176,-0.0017351788,-0.037895575,-0.10679742,-0.11936325,-0.00286109,-0.093260676,-0.117074706,0.05752365,-0.0021862779,-0.03687268,0.039871298,0.010352514,0.08280102,0.034931794,0.03304022,-0.025571682,0.025294663,0.007880976,0.013024591,-0.025666727,-0.00827235,0.048514903,-0.035954513,-0.02301784,-0.054179866,-0.09028659,0.051267207,-0.0054577286,-0.10175082,0.02200684,-0.066063814,0.03407915,-0.00413769,0.043373685,0.1596387,-0.001435272,0.011922778,-0.013189803,-0.09639201,0.04223398,-0.0004906235,0.043036006,0.0026463957,-0.062285665,0.041811846,-0.036767125,-0.031453874,0.0089305155,0.016808737,0.02094685,0.0022873883,-0.016756246,-0.030660255,0.034244373,-0.00859777,0.03598278,0.05696181,0.020056391,0.036274318,-0.07682833,0.017570041,5.7994774e-05,0.03415518,0.093372114,-2.5104521e-08,0.057058398,-0.030551374,0.05504081,-0.0009777601,-0.008044229,0.0040861145,-0.020387258,-0.042771347,-0.0015948784,0.030518131,-0.03324878,0.018086294,-0.00044005315,0.031902857,0.07158691,-0.009681718,-0.064541385,-0.031814206,-0.04280146,-0.08892775,-0.088126116,-0.00923005,-0.026643483,0.06967414,0.037318703,-0.029721983,0.05742663,-0.06609163,0.01258006,-0.031128963,-0.076885454,0.027873429,-0.033729363,-0.07096825,-0.049306184,0.06887886,-0.089658685,0.015374995,-0.03190942,0.061460786,0.051708456,-0.02133669,-0.055174727,0.016464856,-0.023259293,0.021689411,-0.04535099,0.058992274,0.0033847666,-0.02127997,0.05247881,0.0079729995,-0.0178608,0.029392608,-0.061662126,-0.0066387635,-0.038867183,-0.04651131,-0.008236617,0.008459808,-0.023147423,-0.02025254,0.11789192,0.0082517555 +4.2.3.189,Isolated from the plants Marrubium vulgare (white horehound) and Vitex agnus-castus (chaste tree). Involved in marrubiin biosynthesis.,384,1.0,-0.047272082,0.05401322,-0.1520602,0.042260326,0.12927282,0.086055756,-0.04090829,0.019931097,0.012559691,-0.037713848,0.04882834,-0.014733467,0.014348502,-0.1176355,-0.060088232,-0.030134384,-0.051095847,0.031530634,-0.030718068,-0.007370291,0.06581006,0.10121056,-0.049646176,0.031009551,0.020020956,-0.061875362,-0.025964323,0.017311707,0.007281654,-0.020412292,-0.030262046,0.032769166,0.07555199,-0.022461291,-0.00134308,-0.02149613,-0.041839182,-0.032324903,0.06147549,-0.04895055,0.064048976,0.032066736,0.088550195,-0.065612935,-0.032092847,0.028953549,-0.032037806,-0.022004645,0.02663666,-0.027571626,-0.08321698,-0.033736635,0.0025489721,0.091802105,-0.018578144,-0.020181613,-0.016276825,-0.053105656,0.054052293,0.044867948,3.6473033e-05,0.019159263,0.014685081,-0.051432855,-0.08255101,-0.013660732,-0.06562918,-0.012491426,0.083852425,-0.0167058,-0.0022350135,-0.0012014561,0.009315029,0.06331403,-0.0017086914,0.099579625,-0.10392697,0.019430604,0.013470717,-0.044317994,-0.03951746,-0.015144824,-0.009104467,0.04849543,-0.021742294,0.0014782042,0.05064175,0.07795076,0.047636952,-0.0011007896,0.005633452,0.04537258,0.009510416,-0.084421694,-0.07978062,-0.0136493435,0.036873776,-0.055393446,-0.016566405,0.009402391,0.0073695937,-0.02571322,0.059670087,-0.12228604,-0.117119946,0.05334856,-0.07490958,0.0031951375,-0.0051195477,0.01341074,-0.04539079,0.015876068,-0.00892763,-0.067373835,-0.009633426,-0.0045841564,0.05276567,-0.08017733,0.023248792,-0.017812552,-0.0011750376,0.022404028,0.15633103,0.023785401,0.06398233,-0.025243785,-0.06549923,2.8134618e-33,0.025768457,-0.059957124,0.00068419473,-0.0048356783,0.0129658505,-0.031200554,-0.053574964,0.01140149,-0.04146835,-0.036230665,-0.08127022,-0.077412136,0.031088041,-0.076845795,-0.037290864,-0.009178337,0.04671117,-0.08963098,0.062251303,0.0039084787,0.011135241,0.08228148,-0.0010214818,0.03923776,-0.031223837,-0.02595562,0.06156541,-0.008264318,0.015023314,0.008054442,0.06592794,-0.07888803,-0.01860475,-0.039789207,0.06338485,0.06878865,-0.081670396,-0.068300694,-0.07466458,0.056139875,0.085235484,0.02529043,0.0816101,-0.02314068,0.05553377,0.086941615,-0.021834848,0.0755812,0.08892097,0.006619199,-0.017743537,-0.042638782,0.054194644,0.013529103,-0.095791295,0.004874203,0.037767116,0.048048362,0.054839738,0.052173354,-0.021675125,0.029968033,-0.046981253,0.015571397,0.00106234,0.06465072,-0.12727612,-0.018814744,-0.06463794,-0.0072409795,0.009418558,-0.059067078,-0.017595315,-0.027285209,0.008693133,-0.003298641,0.0048751663,-0.034495533,-0.00052120467,0.05323678,-0.015350563,0.033409063,-0.016414592,0.03528856,-0.048486732,-0.06007706,-0.047658697,0.10162573,-0.057151787,0.04163301,0.057089042,-0.01410521,-0.007811437,0.050792236,0.035935648,-2.7749677e-33,-0.008365938,-0.007677138,0.084658206,0.038913686,0.014931909,0.10390132,-0.018001692,-0.0075779133,0.021134209,-0.050888598,0.008140777,-0.008563498,0.10462382,-0.050999083,0.010805029,0.008297507,0.071587235,0.09711213,0.005143345,0.04498436,-0.114329875,0.057461143,0.039449267,-0.0808806,0.03243489,0.016766703,0.044613842,0.1129426,-0.062770896,0.037789162,0.019051535,0.019536551,-0.06730847,-0.074005336,-0.08098566,-0.034506902,-0.05496926,-0.03880089,0.086203866,0.018105222,-0.061708327,0.032099687,0.011390193,0.06488796,0.07766169,0.006992773,-0.0035300436,0.04216756,-0.0661481,0.0782432,0.031412672,-0.007122011,0.033306222,-0.044726465,0.025179554,-0.014251834,0.008286399,0.08572907,0.015675893,-0.009417885,0.034770958,0.0063759605,-0.015489441,0.030612666,0.03487718,0.09504537,-0.052308034,0.005265782,-0.00667493,-0.014405432,0.051323414,0.07851458,0.020801654,0.08342013,0.055904232,0.05596821,-0.064544365,-0.008097327,-0.070820995,0.048415493,-0.035554808,-0.038535807,0.0065949825,-0.040032223,-0.06925819,-0.01941069,-0.0067579923,0.042461477,0.07122835,-0.01894365,-0.09560223,0.034549113,-0.056254454,0.042255964,0.08714192,-2.6984841e-08,-0.039440732,-0.073337056,-0.019414918,-0.031257626,-0.023639161,-0.03747254,0.008620952,-0.00036375553,0.006652876,0.0038278191,-0.06493041,-0.014663639,-0.028835207,0.009674005,0.030903252,0.0067967186,0.037946597,0.032775525,-0.01846611,0.03624018,-0.010044902,-0.03680472,-0.009398428,0.03765658,-0.047325905,-0.10025047,0.030354999,-0.06282167,0.008456006,-0.029020166,0.063973896,0.021791391,-0.06988466,-0.062564954,-0.048453562,0.05339562,-0.043534413,-0.00643061,0.025391236,0.009580606,0.008319586,0.005639552,-0.06191237,-0.0101177115,-0.06595005,0.0073257545,0.035335783,0.07413343,-0.056958634,-0.11619216,0.046538882,0.018198423,0.0017774041,-0.026410945,-0.044831477,-0.055285115,0.13003977,-0.06126603,0.020767422,0.0022949213,-0.101663075,-0.008499274,0.10034486,0.08052732 +4.2.3.190,"Manoyl oxide is found in many plants. This enzyme has been isolated from the plants, Grindelia hirsutula (gum weed), Plectranthus barbatus (forskohlii) and Marrubium vulgare (white horehound).",384,0.99999994,-0.051636007,-0.029924052,-0.11673509,0.03986852,0.07186484,0.03167299,-0.0258292,-0.0470376,-0.012876508,-0.016644018,0.07593981,-0.043804917,-0.06751695,0.014262447,-0.056373212,0.04968968,-0.029670486,-0.044584934,0.06027624,0.009192213,0.11398431,0.05843643,-0.08902267,-0.029821366,-0.026779,0.021007618,-0.08786988,0.01577471,0.017094107,-0.062320456,0.016869793,0.08630887,0.12962954,-0.095375374,0.03127096,0.024234343,-0.009577092,-0.04719932,0.05623053,0.045268796,-0.021011753,-0.02593408,0.012377282,-0.045394387,0.0039177905,-0.007095947,-0.0055722143,-0.024804767,0.093548544,-0.042187523,-0.032658033,-0.045138296,0.0020458,-0.066261694,-0.015806679,-0.04872793,0.089920245,0.0495266,-0.035884395,0.005805093,0.050714605,-0.015424947,0.0017440505,0.007054717,-0.026065359,0.033092793,-0.03728386,-0.0052771876,0.07108832,-0.025689226,0.010924369,-0.08112408,0.07038581,-0.005403986,-0.0778886,0.040945936,-0.04581943,-0.017316796,0.06274036,-0.02804862,-0.021389391,-0.014159638,-0.025348306,0.042980883,0.016496092,0.06816608,-0.054725416,0.039010566,0.022327676,0.021007255,-0.01765901,0.03621011,-0.07136013,-0.03985255,-0.019586429,0.052029915,0.028304616,0.023465618,-0.060708184,-0.0568273,0.0485205,-0.037903186,-0.027563259,-0.13904516,-0.041739937,0.12071451,-0.04191355,-0.0065559573,0.07187757,0.04630344,-0.087819986,0.063664146,-0.0574093,-0.023605414,0.0339125,-0.035140622,0.0094538145,-0.07573564,-0.109856255,0.0023797979,-0.013443324,-0.037108537,0.057692103,0.0045479205,0.06234618,0.017304884,-0.050614465,3.100179e-33,0.04313416,0.055877246,-0.016300024,-0.0070582107,-0.038798768,0.017537018,-0.031653393,-0.011735626,0.042218048,-0.06258352,-0.031686556,-0.045718618,-0.06638405,-0.033960946,-0.0017608829,-0.045676798,-0.0011799226,-0.03922936,0.07219113,0.01077871,-0.0041427244,0.065323584,-0.11670639,0.0024198543,-0.009886235,0.07042514,0.00021112153,-0.14358723,0.07699508,0.0031562592,0.080266744,-0.021077149,-0.0036267887,0.008728402,0.037523072,0.04011573,-0.047005087,-0.026932392,-0.08819468,0.04216666,0.0830147,0.04019559,0.029150797,0.01268073,0.013462087,-0.07698554,-0.049483635,0.14692268,0.12601857,-0.02904688,-0.041471954,-0.0020584324,0.0767405,0.0021920828,-0.046993718,0.030005077,-0.01974338,0.043019857,0.053237233,0.06771811,-0.06941619,0.04372723,-0.018766347,0.050302025,0.029768039,0.019354226,-0.06654028,-0.018963728,-0.014418032,0.085426286,0.010338191,-0.0123162195,0.0076615647,0.087124236,-0.021621091,-0.021745428,0.06274863,0.08468663,0.0015443513,0.011876821,0.034025393,-0.049371254,-0.00610027,-0.0771173,-0.021997403,0.05045263,0.023011459,-0.007501398,-0.009366252,0.042775635,0.053158667,-0.07300477,-0.0010610884,-0.010580224,-0.0050698607,-4.6023113e-33,0.05550233,-0.036395047,0.10092457,-0.047957778,0.0029950023,0.09914553,-0.026842486,-0.005566395,0.025582476,0.0118325,0.015718259,0.021767251,0.124982096,-0.06532192,-0.00017336445,0.040583316,0.017522393,0.064583205,0.026482197,-0.03704732,-0.062736146,0.00864113,0.020569948,-0.05637105,0.022757895,0.023981435,-0.07927973,-0.032080226,-0.015419745,0.065046795,0.04629789,0.009127475,-0.07173936,-0.030834543,0.0014836474,-0.016963024,-0.10972036,0.028473312,0.045588445,0.09821387,-0.0820241,0.023677906,0.0764148,0.030748028,0.0147563955,0.050523836,-0.10053202,0.04603384,-0.034235615,0.023128338,0.029073466,0.0396698,-0.09657569,-0.040405795,0.04275912,0.022594815,0.028023273,-0.011466489,-0.10810615,-0.02982742,-0.042930502,0.034496643,-0.06785813,0.05643094,-0.010945086,0.09733068,0.02047204,0.044875342,-0.05680404,-0.0064168656,0.008884271,-0.0181463,0.04842119,0.05816086,-0.0025395406,0.05395682,-0.033100802,-0.0110149905,-0.019373944,-0.04798172,0.034419883,0.032955214,0.022362325,-0.0628574,-0.04321329,-0.050033845,-0.0028784333,0.050199065,0.053238597,-0.00014107548,-0.08092184,0.023397658,-0.0965804,-0.006879414,0.14638905,-3.5973397e-08,-0.028733086,-0.010932074,0.1219724,-0.082316175,0.06274779,0.0025017823,-0.015800806,-0.010636031,0.08713656,-0.042920947,0.004130062,0.03174695,-0.0252273,-0.057525225,0.015266116,-0.07418981,0.025921438,0.03060525,-0.022228055,-0.01656031,-0.03691056,-0.04235942,-0.046458207,0.011214138,-0.017307483,-0.009923179,0.042492136,-0.011966224,-0.03585785,0.03690872,0.0014891688,0.054288715,-0.074979976,-0.059152115,-0.018940002,0.07081891,0.018197464,-0.0024793574,-0.07791289,0.032844156,-0.048183493,-0.07774057,0.040713996,-0.012975928,-0.039646838,-0.040288847,-0.00652744,0.00082918064,0.038086146,-0.020355858,-0.009235657,0.0064374586,-0.0071069975,-0.062194932,-0.05903796,0.037103347,0.009226406,-0.03062138,0.016727049,-0.06952216,-0.083657086,-0.0038172102,0.15466939,0.060217578 +4.2.3.191,Isolated from the fungus Sordaria araneosa. Cycloaraneosene is a precursor of the antibiotic sordarin.,384,0.9999999,-0.030641317,0.0187451,-0.17452943,0.03174492,0.029648554,0.041148603,-0.082248,0.024669956,0.072923295,-0.08650996,0.055098098,-0.02172825,-0.04032293,0.04871395,-0.10615828,-0.010271624,-0.0059522013,0.028829841,0.0198929,0.03393687,0.02158139,0.07264885,0.07992635,0.04534583,-0.008758376,-0.002735203,0.019021453,-0.0017616358,-0.044091254,-0.03640531,0.03944624,0.016881116,-0.0030094674,-0.041334312,0.00944182,0.043017436,-0.038593218,0.031888828,0.09405328,0.061883453,-0.11499668,-0.043297805,-0.07025947,-0.008525165,-0.061618477,-0.016086074,-0.06336986,0.018188428,0.07216123,-0.013820625,0.029145923,0.0020527493,-0.0949837,-0.01463883,0.04149955,0.01272775,-0.067167364,-0.03327854,-0.01225282,0.0140094925,0.10866982,0.040474374,0.019702166,0.040589705,-0.07690429,0.07097252,-0.013329782,-0.043251384,0.05369949,-0.025716105,-0.036651146,-0.06551405,0.013532492,0.09796573,-0.044400763,-4.7841484e-05,0.04930433,0.0048993067,0.036801994,-0.020268466,0.067222886,-0.0082431985,-0.0012412411,0.114058755,-0.00350993,-0.019464646,0.06554318,0.04834106,-0.022818785,0.045055475,0.12865083,0.08770171,-0.0062798494,-0.061149955,-0.029794844,-0.015447106,0.018315617,0.032257278,0.021655818,-0.015596979,0.046419237,-0.06357881,0.027054453,-0.04529984,0.019532988,0.021393256,0.0073018097,-0.03193675,0.092571124,-0.02652391,-0.046068773,-0.040726345,-0.065518424,-0.09170858,-0.0023894918,0.037304513,0.08345193,0.012028308,-0.016887464,-0.016552258,0.02614463,-0.0039827316,0.0027846438,0.048041355,0.041084424,0.04805924,-0.077596396,2.640999e-34,0.020015867,0.0041591246,0.014922317,-0.0417646,0.016040567,-0.046153612,0.06338443,1.2144356e-05,-0.042192712,-0.05807475,-0.07977156,-0.10312981,-0.04307234,0.035703845,0.036063366,-0.0028997918,-0.06040343,-0.07046196,0.06786033,-0.023477761,-0.0055063195,0.054845437,0.020049889,-0.03433629,0.052812863,0.024967453,-0.068820976,0.020345643,0.09170227,-0.015847022,0.048697803,-0.12039023,-0.09798068,-0.0048263976,0.021337155,0.049307626,-0.02428915,-0.008000169,-0.00079251546,0.009490823,-0.0056440206,-0.022524491,0.016080137,-0.0045327214,0.04035979,-0.004264913,-0.12141045,0.09588742,0.014629385,-0.059323277,0.020550858,-0.03548407,-0.02957517,0.05854558,-0.050338477,0.014991752,-0.014135348,0.083174095,-0.022520902,0.061605766,0.08697219,0.087193616,-0.029087596,0.09232896,0.06840441,-0.004512468,-0.02931034,0.0014698452,-0.041992556,-0.12499812,-0.03990763,-0.024127878,0.053167153,-0.004168634,0.00089249964,0.06454004,-0.036746778,-0.021526447,0.021966597,-0.015822265,-0.06450619,-0.029847039,0.07415392,-0.01272778,-0.03568122,0.099459745,0.003693903,-0.036593806,-0.060914915,0.13041203,-0.049822133,-0.10838946,-0.046642326,0.020352827,-0.012140884,-2.3857492e-33,0.06298744,-0.046504248,0.050104402,-0.067326,-0.02418354,0.1417188,-0.0131269535,-0.023063235,-0.058649175,0.017144257,0.020996984,-0.038777515,-0.011566714,-0.038124964,0.043289784,-0.007351064,0.02392344,0.065369286,0.030515721,0.0235985,-0.0144811105,0.047169574,-0.018840553,0.016875487,0.040499065,-0.0027015053,0.116585016,0.023251373,-0.047690835,0.004557299,0.0089619355,-0.024112185,-0.046253063,-0.08104555,-0.026059723,0.073136844,-0.04178842,-0.1150361,-0.007356328,0.0023164353,-0.0884439,-0.045036305,-0.07237766,0.08258268,0.072410986,0.032351676,-0.051957153,0.028770735,0.017632784,-0.014094338,0.04038875,-0.006415179,-0.0024619338,0.019614948,0.00036477728,0.0046554673,0.04074026,0.005438451,0.07151355,-0.06603814,-0.0021356686,-0.023119494,-0.0600153,-0.05582628,0.08763503,0.04800089,0.0034620725,0.0066857175,0.029084682,-0.103521325,0.04485716,-0.030848762,-0.050256304,0.07449227,-0.039284214,0.032959558,0.03145657,-0.036067497,0.039473504,0.039697543,-0.018737711,0.016564375,0.03800373,-0.00089173287,0.018020684,-0.060908537,0.080392525,0.037186492,0.002851416,0.025706908,0.011791713,0.048368428,-0.101866074,-0.016991215,0.032981962,-2.0459046e-08,0.09868129,-0.020363022,0.024392916,-0.103707306,0.036177013,-0.045877233,0.06267986,-0.020986663,-0.051863782,-0.027350128,-0.07540242,0.073477395,0.008422621,0.007844993,0.004373002,-0.06742971,-0.0056950864,0.0556314,0.013724868,-0.08928336,-0.07385726,-0.004103848,-0.07515795,-0.05665833,0.03252865,-0.10200549,0.073112145,-0.0051098177,0.047298834,0.0016416239,-0.017303273,-0.03463447,0.006555883,-0.05324101,0.05520905,0.035768833,-0.0737092,-0.046358213,0.055540785,0.022328498,-0.06669081,-0.035336874,0.038486537,0.018488057,-0.023141783,-0.067658685,0.0004090106,0.058183093,0.0075992667,-0.028102053,0.009518067,-0.023099309,0.0078002717,-0.050900593,-0.052992783,-0.018831456,0.032199964,-0.034685995,-0.036022745,-0.00829181,-0.07919129,0.0042661084,0.14082527,0.019377867 +4.2.3.192,Isolated from the bacterium Streptomyces clavuligerus.,384,0.99999994,-0.038562708,0.015152628,-0.17345053,-0.005825991,-0.0034086157,0.05645354,-0.012960928,0.050054695,0.08277763,-0.08170336,0.025506573,-0.05369447,0.050464764,0.036627218,-0.072051734,-0.035949104,0.021544617,-0.025744727,0.09264257,0.008468012,0.032869905,0.10423039,0.015695212,-0.03926806,0.03380736,0.06326376,0.011335481,-0.009353359,-0.015882898,-0.025748404,0.0313212,-0.054931138,0.040002882,-0.03526942,0.12881592,0.056586646,-0.029491555,-0.012851337,0.16889717,0.06556503,-0.045484796,0.050727487,0.01929078,0.0258306,-0.054552402,0.08528584,-0.004547351,0.0848769,0.05979345,-0.05654297,0.015968155,-0.0666802,-0.069902904,0.027682854,0.055494733,-0.0048342203,0.016331391,-0.03231418,0.0044174874,-0.014119899,0.039033905,-0.012449779,0.081170216,0.0126387235,-0.10130026,-0.030511856,-0.021256186,-0.00045114104,0.09204655,-0.018099856,0.0071749478,0.015752876,-0.022292554,0.076789364,-0.035132073,0.017480409,0.012274289,-0.01778657,-0.030876063,0.011639608,0.017789662,-0.011440462,0.0065384656,0.07360489,-0.0030214854,-0.06440124,0.05546235,0.032240294,0.038605582,0.0028425213,0.033543404,0.034090575,-0.005423642,-0.052664965,-0.07153836,-0.012289202,-0.071229376,0.02159404,0.0126320785,-0.00791994,-0.04724483,-0.021564798,0.124642,-0.021460256,-0.020654341,0.011606178,-0.05082767,0.018616965,0.06719023,-0.05345403,0.0020525604,0.043715574,-0.04636178,-0.0609321,0.0906715,-0.021019574,0.17371634,-0.041111898,-0.025892738,-0.006246615,-0.041488905,0.010843748,0.07606127,-0.0042997086,-0.018493718,0.075352855,-0.06463888,1.4211723e-33,-0.019235745,-0.05248563,0.08314244,-0.06373028,0.01891112,0.006914791,0.011820566,-0.022619214,-0.016986348,-0.023898255,-0.040372834,-0.10806821,-0.0076777996,0.0035382733,0.037307803,0.022878772,0.004726985,0.014274699,0.0284465,-0.054796077,-0.0024990225,0.052629784,0.022509431,-0.017925737,0.021243766,-0.0063865674,0.0036583163,-0.019271744,0.14795874,-0.05019956,0.08009319,-0.039842077,-0.08319062,-0.052947037,0.029114924,0.019207088,-0.060608618,-0.026651543,0.028347611,0.028449034,-0.00084557064,-0.02661912,0.04245192,-0.0067421435,0.072111584,-0.029445032,-0.06825291,0.061307263,0.034623478,-0.010084426,-0.0209567,-0.03583148,0.042288177,-0.01929991,-0.07852073,0.00595979,0.044095505,0.05314842,0.036927056,0.04164867,0.05791084,0.08111208,0.0111326985,0.011703544,0.091995366,-0.005435742,-0.04935515,-0.024886662,-0.05252977,-0.0030963705,-0.023474967,-0.02427679,-0.011475954,-0.08130321,0.0033325106,-0.042584557,-0.072270736,-0.05386225,-0.0009809801,-0.018636877,-0.07195188,-0.008219254,0.05877885,-0.04833214,-0.08683974,0.071099035,-0.0727751,-0.0125626195,0.02943768,0.089426614,-0.07274839,-0.003735462,-0.14117993,0.041366395,-0.042838585,-2.2435759e-33,0.09171281,-0.06290611,0.043144412,0.008982995,-0.043624822,0.12722638,-0.11264582,0.059868384,-0.091117315,-0.017002765,-0.0032808525,0.007512646,0.024468193,-0.047928028,0.02549123,0.051197443,0.012684529,0.13022274,-0.05456722,0.03552199,-0.005015092,0.0248923,0.018862763,-0.034712017,-0.008231898,-0.015853247,0.025128447,0.009376211,-0.008277562,0.0050347513,0.018258706,-0.0054193395,-0.064972594,-0.058373418,-0.070624895,0.00443243,-0.044762,-0.05474942,0.0883862,0.0033046152,0.006980928,0.03377082,0.0058725993,0.07039531,0.035148937,0.019632764,0.0023049628,0.038606368,-0.0075768093,0.047424484,-0.04901414,-0.03416306,-0.00028831288,-0.012304912,-0.013466345,-0.02291389,-0.06532088,0.027454088,0.021358475,-0.07119924,0.009359479,-0.03846475,-0.0471113,-0.010808366,0.13420892,0.07633711,-0.021747336,0.0672498,0.027177114,-0.08491354,-0.008476176,-0.016217366,-0.066712,0.03855457,0.043742288,0.048281994,-0.069935486,-0.024109978,0.022289446,0.03839599,0.02519088,-0.07635306,0.06117493,-0.04133721,0.025860416,-0.058983624,0.045132663,-0.054091487,0.014372716,0.01439213,-0.026372224,0.029637253,-0.009370452,0.017521698,-0.008608904,-1.9126826e-08,0.07252732,-0.03165196,0.043647315,0.021216037,0.008109738,-0.083642855,-0.041821435,-0.051039893,-0.0078593725,0.05620588,-0.08473676,-0.091665216,-0.01668611,0.013242367,-0.010432845,0.01965468,-0.028262626,-0.038981434,0.02894918,0.014440702,-0.07918301,-0.030688785,-0.0008864833,0.09552079,0.033328503,-0.044428606,0.054013107,0.004260788,0.053670894,0.03887172,0.024343334,0.0038318736,-0.053182296,-0.020024655,0.02358997,-0.00019246161,-0.09281975,-0.027875232,0.0074768434,0.026930613,0.015163851,-0.022634536,-0.013928278,0.007048418,-0.09970554,0.034652658,-0.031249769,-0.0072475607,-0.11331804,-0.06681414,0.08105209,-0.005448318,0.038830765,0.055657152,-0.10268328,0.034819882,0.03996693,-0.08961808,-0.0588424,-0.017510846,-0.050142452,-0.02511712,0.13355592,0.05373507 +4.2.3.193,Isolated from the bacterium Streptomyces cyslabdanicus.,384,0.99999994,-0.05649092,0.05603405,-0.1748563,0.016764373,-0.0462611,0.06816266,-0.022088619,0.04438611,0.06970162,-0.08190293,0.052842822,-0.043603092,0.07516162,0.024548484,-0.04751811,-0.07479082,0.0008192637,-0.016969616,0.057057347,-0.058176998,0.028483335,0.13224268,0.0034898012,-0.032142866,0.017650716,0.02403008,-0.05688281,0.022243718,-0.030970637,-0.01796132,0.041423418,-0.06779465,0.04829098,-0.014943931,0.13176008,0.06040592,-0.0669299,-0.0043910206,0.14205554,0.03251276,-0.04288625,0.025485286,0.033026583,0.07796061,-0.044848032,0.08637702,0.03851177,0.069475055,0.031123776,-0.08753087,-0.036895808,-0.0614369,-0.034280118,0.07429278,0.029407058,0.018661946,-0.017490538,-0.016829206,-0.00224545,-0.067441665,0.049235713,0.006499592,0.029531486,0.006975342,-0.11660869,0.0061237593,-0.03510555,-0.03867927,0.09692461,-0.015603249,-0.038366202,0.010693984,0.007938425,0.08803998,-0.059986312,-0.0056547513,0.010171593,-0.03769742,-0.053173903,0.040138893,0.053480282,-0.0442899,-0.01776251,0.06038398,0.01991845,-0.05048243,0.03617372,0.055895682,-0.0056189345,0.012972032,0.049171943,0.048648585,-0.02412183,-0.072558284,-0.045470368,-0.022971535,-0.064971864,0.024755476,0.01810202,0.017864665,-0.012097465,-0.015612167,0.11520727,-0.022331303,-0.015199053,-0.0058767376,-0.044080913,0.0055182665,0.059495036,-0.05963194,-0.050143797,0.028343841,-0.08048261,-0.062870435,0.063547306,0.0023606906,0.16453919,-0.027580082,-0.050893333,-0.020218449,-0.0055928705,-0.016625235,0.09120652,0.000451384,0.011941538,0.0635335,-0.1317539,8.538639e-34,-0.045422174,0.0058264825,0.08754084,-0.06368945,0.03971588,-0.010535967,0.016444288,-0.033549525,-0.012250369,-0.0107031185,-0.03229372,-0.0796198,0.001384643,-0.0075796056,0.021276366,0.04082858,-0.015094285,0.046058025,0.047758203,-0.06739577,0.018785225,0.02096869,0.02550237,-0.036229976,0.0033450967,0.0049613165,-0.0033380252,-0.019097703,0.102435514,-0.025661968,0.031314585,-0.07360061,-0.09083662,-0.033503618,0.083885804,-0.028701218,-0.09381875,-0.04561955,0.061965697,-0.01220387,-0.027125489,-0.016684582,0.0814711,0.010436578,0.077455886,0.0103944205,-0.08813524,0.03580232,0.048757836,0.00040352548,0.032569267,-0.045408517,0.06266186,-0.019502312,-0.07972633,0.025001535,0.032389496,0.112214744,0.03256254,0.027237317,0.021883655,0.069810346,-0.025733063,0.011576669,0.10863783,0.008854006,-0.06436805,0.014505299,-0.09843579,0.018410478,-0.0350299,-0.027740069,0.027502684,-0.0485951,-0.004000824,0.012047944,-0.042217974,-0.015228545,0.043818124,-0.016639145,-0.06573357,-0.0044937967,0.011850436,-0.033308282,-0.07737493,0.1048882,-0.0065622614,-0.033022385,0.026546879,0.10690297,-0.02239553,-0.051192146,-0.12766096,-0.0026119563,0.013640388,-2.4823316e-33,0.08253373,-0.0016899483,0.008466533,-0.023812016,-0.0024466084,0.084482074,-0.084427394,0.06192434,-0.049836993,-0.014573939,0.012197305,0.018115852,-0.009076825,-0.031387363,0.0109681925,0.010767955,0.0684801,0.118231684,-0.014436116,0.063524306,-0.02121889,0.037427887,0.034824073,-0.055233497,0.007797215,-0.02185219,0.05879357,0.059123486,-0.00884084,-0.027955664,0.026436172,-0.007060614,-0.048240896,-0.103940584,-0.08454545,0.024912525,-0.10040806,-0.08311994,0.1148867,-0.0294594,0.053105064,0.01923079,-0.002043399,0.07628818,0.06732552,0.04851558,-0.02133071,0.060928777,0.018979928,0.049288154,-0.034586124,0.012368973,-0.008304002,-0.025186548,0.035540916,-0.010641089,-0.04230169,0.052994844,0.0076876753,-0.07416854,0.005357823,-0.011728588,-0.040267628,0.003438028,0.103670046,0.021494146,-0.016927838,0.050475784,0.008389644,-0.017440107,-0.0009348021,-0.00562419,-0.07201473,0.006978673,-0.023830164,0.065623365,-0.06959157,0.012992391,0.00024353992,0.0477224,0.03792575,-0.04784075,0.048374932,-0.02213267,0.021091875,-0.08401972,0.017926827,-0.009106575,0.024409179,-0.021811258,-0.035284393,0.019401448,-0.01243385,0.0078092446,-0.02839225,-1.9161645e-08,0.074460045,-0.038619194,0.028722277,-0.041228984,-0.021929557,-0.05535396,-0.018402966,-0.048973992,0.0022579522,0.01904427,-0.032635156,-0.09214604,0.018105354,-0.003199159,-0.053684738,0.0012071871,-0.07464706,-0.038998507,0.03531717,0.00837881,-0.09738243,-0.0040662047,-0.003852242,0.07102465,0.052276324,-0.048322607,0.08699502,-0.038768906,0.022638993,0.008860486,0.056624055,-0.025770402,-0.044153333,0.010808253,0.0036729027,-0.019314343,-0.09980833,-0.012721432,0.018277204,-0.0029905569,-0.009853808,-0.020267636,-0.024563411,0.047358226,-0.110518485,0.045101687,-0.03180523,-0.022068093,-0.0756936,-0.07599885,0.022618014,0.0066273054,0.017988272,0.015667131,-0.06011149,0.02381092,0.05385379,-0.04325931,-0.0631855,-0.0196769,-0.037076827,-0.057442628,0.10492965,0.059841454 +4.2.3.194,Isolated from the plants Valeriana officinalis (valerian) and Persicaria hydropiper (water pepper). The enzyme does not act on farnesol or drimenol diphosphate. Using 18-oxygen labelled water 18-oxygen was incorporated suggesting involvement of a stabilised carbocation or an equivalent species.,384,1.0,-0.049024425,0.022166336,-0.116792105,-0.02243711,0.08156719,0.03231186,-0.101604395,0.057963405,0.070852526,-0.12684332,0.067291304,-0.076692484,-0.07217963,-0.0034775347,-0.07377008,0.08784383,-0.041928682,0.06009055,0.011918745,0.017119773,0.007153897,0.07492982,0.019815864,-0.034736678,0.01757586,0.08851839,0.02838786,0.06176432,0.028526494,-0.102729544,0.02256868,0.0670797,0.0972413,-0.09641706,-0.01159286,0.098741576,-0.039759587,-0.038476173,0.048534177,0.04849659,0.020395612,-0.032732993,-0.00014197834,-0.06613705,-0.025919428,-0.046274785,0.001910066,0.051124837,0.009543813,-0.02667595,-0.023193136,-0.055292714,-0.05708885,0.028460998,-0.0599869,-0.05679931,0.009393088,0.041028783,0.0034793771,0.030647743,0.06495671,0.054713957,-0.0113483025,-0.0084129935,-0.0901577,-0.019397028,-0.033323843,-0.03665341,0.09132819,-0.116423674,0.0069775786,-0.061690032,0.0483102,-0.036388773,-0.105253525,0.055804636,0.038875807,0.06913076,0.09850515,-0.056963038,-0.053166438,-0.010112564,-0.025511963,0.034008447,0.016001852,0.06430304,-0.040022157,0.032127786,0.025245106,0.017793695,-0.003180189,0.035442244,-0.039004132,-0.012145563,-0.0407911,0.026929231,0.06320569,-0.017824937,-0.023297267,-0.0034590673,0.017121295,0.064049646,-0.09682064,-0.08613847,-0.01874725,0.017947594,-0.028121052,-0.040259477,0.0782931,-0.088967614,-0.012023335,-0.0018202603,0.015232325,-0.015551841,-0.0052355863,0.025444392,-0.0029499517,-0.0477016,-0.045014065,-0.008004255,-0.08920125,-0.05066415,-0.021470753,-0.02490724,0.030523943,-0.018165328,-0.08580259,4.4866456e-33,0.03529214,-0.0090656895,-0.005109712,0.0024764598,-0.019546004,-0.06269089,-0.034374926,0.045652036,-0.033147875,-0.026227755,-0.08557361,0.025025047,-0.03788541,-0.04273382,0.009963022,-0.026509754,0.069147885,-0.0463282,0.06990152,-0.05410787,0.03618609,0.045144632,-0.07699237,-0.02679099,0.00667501,0.0653877,0.07256787,-0.056906715,0.059819505,-0.026502145,0.02700368,-0.110608965,-0.004652434,0.005655539,0.05692943,0.055886786,-0.07313747,-0.015293272,-0.07058343,0.025340015,-0.04627294,0.08024678,-0.024105169,0.020192912,0.06645328,-0.057490863,-0.060755413,0.057175342,0.100457646,0.04682592,0.017982312,0.010267488,0.09155382,0.049568802,-0.088538714,-0.0055585224,-0.05518022,0.066388585,0.0079697985,0.015252978,-0.004843193,0.099899895,-0.01319993,0.004289824,0.03767013,0.052150693,-0.13618237,-0.041553397,0.058517918,0.062317185,-0.04510336,0.020763582,0.041866448,-0.05313983,0.027360832,-0.02654359,-0.009816088,0.0005664007,0.049797166,0.0074990992,0.05754475,-0.0055142376,0.06445642,-0.012885372,-0.063824765,0.024898084,-0.038842365,0.031974804,-0.0032064721,0.15230855,0.027136842,-0.056083836,-0.027638588,-0.038624626,0.038376857,-3.775653e-33,0.07335457,-0.07308903,-0.0069331788,-0.041904382,0.036016293,0.08090114,-0.066162504,0.0038710337,-0.049158942,-0.032091007,0.0074869115,0.012727944,0.09060532,-0.027264673,-0.008863653,0.07085418,0.03265682,0.11252787,-0.024336277,0.010010595,-0.09719461,0.074936196,0.002497362,0.009838007,-0.034005135,0.020870453,0.07722367,-0.055443443,-0.03819071,0.015558659,0.10968346,0.007280182,-0.011070411,-0.05716319,0.0406191,0.008733498,-0.0730547,-0.019667549,0.02549369,0.05309981,-0.062561415,0.0029523855,-0.01855414,0.096283585,0.027318602,0.02110246,-0.059307914,-0.039354507,-0.06386429,0.050993606,0.0473024,-0.005759106,-0.030107489,0.027818594,0.032351892,-0.05116896,0.013013421,0.004108154,-0.031689588,-0.045973793,0.0005511388,-0.09069309,-0.024968699,0.023591343,0.031225193,0.083428994,-0.01660276,0.10308145,0.0014041818,-0.0024759558,0.07146201,-0.0034313027,0.04006863,0.08174978,-0.006737674,0.030679794,0.049755413,-0.071485445,0.02035462,-0.038797278,-0.03342611,0.011385537,0.016980434,-0.068994276,-0.030368462,-0.081498556,0.041766055,0.0078871725,-0.00044310515,0.060332682,0.05992429,0.014884212,-0.054101333,-0.017577607,0.16885205,-3.7620264e-08,-0.024176752,-0.073173195,0.025651854,0.055601683,-0.040678695,-0.012797048,0.048822027,0.012245179,0.0012744145,0.014943636,0.010679508,0.0297425,-0.0047271694,-0.07163118,0.063800216,-0.025946476,0.08795596,0.06163321,-0.036295786,0.01976531,-0.060502436,0.016566832,-0.040079724,-0.026594676,0.013455703,-0.08740929,0.030655647,-0.056519695,0.034068063,-0.033981007,0.0963036,0.057309702,0.0029688645,-0.051644854,-0.009944722,0.031013079,0.019483479,-0.033242848,-0.048271507,0.035729494,-0.012387314,-0.023368793,-0.05484599,-0.0018428776,-0.022058992,-0.010335395,0.000555764,0.00030809653,-0.015217842,0.01885292,0.02983532,-0.006760904,0.06643787,-0.08779227,-0.058357257,-0.0014552398,0.028250953,-0.014719728,-0.05433821,-0.042330384,-0.048446313,0.013272635,0.113682285,0.0039732098 +4.3.2.7,"The enzyme, found in bacteria, fungi and animals, is specific for glutathione (cf. EC 4.3.2.9, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.",384,1.0,-0.063002884,-0.041766424,-0.10808723,-0.023163741,0.038013108,0.029537603,-0.046068396,0.07376965,-0.005352735,-0.01336987,0.08346732,-0.013612876,-0.003945327,0.048293415,-0.06663861,0.027085997,-0.026901908,-0.0252391,-0.039830968,-0.08388237,0.065906905,0.066769235,-0.05401046,-0.026007462,0.017970856,-0.011364845,0.045586117,-0.043162465,-0.023381708,-0.025258625,-0.047519065,-0.09840895,0.02773459,-0.008800077,0.062155936,0.09093511,-0.090977296,-0.038073063,0.106627025,0.015714467,0.007481534,0.010711669,0.0014909822,-0.07432906,0.027286505,0.010011286,-0.011168176,0.018490762,0.03645638,0.006175043,-0.0029037187,-0.06048056,-0.0013689693,0.07038811,0.039997444,0.000497387,0.0071743396,-0.085417114,-0.050807424,0.08209961,-0.0043489896,0.012025517,-0.021407126,-0.058986194,-0.0042368993,-0.046500478,0.02811921,-0.07131617,-0.03281239,-0.09514897,-0.044542942,-0.06517463,0.011738522,0.0033175622,-0.029090682,-0.028628767,-0.060655136,-0.023675356,0.037752304,-0.022957288,0.10007838,-0.029089725,0.07573352,0.06695284,0.039135184,0.009004592,-0.004484034,0.049233824,0.071464695,0.005644679,-0.014610534,0.019721929,-0.051758725,-0.04866251,-0.095321804,0.024768578,-0.03533626,0.024713945,0.023907803,-0.009219899,0.03925975,0.002716988,-0.053834125,-0.07569522,-0.108160056,0.0029607052,0.036607023,0.103606425,0.005383527,-0.042,-0.016701799,0.04252468,-0.022609882,0.0013895225,-0.023316232,0.07547973,0.06370496,-0.03622698,-0.10255238,-0.01662366,0.02294842,0.025601862,0.058069218,0.057324845,-0.009947515,0.07702315,-0.054549973,6.1824285e-34,0.066617146,0.082471706,0.021834493,-0.05105621,0.0017953067,0.048032608,-0.08841604,-0.016731013,0.013760239,-0.09161092,-0.08210013,-0.058165684,-0.024569133,-0.018892959,-0.012803131,0.025892269,-0.035258528,-0.0017521165,0.03920561,-0.006542659,0.062391076,0.041758608,-0.010032696,0.024143668,0.004168391,0.10667514,-0.015077747,0.016841276,0.04344264,0.0020335817,-0.04950541,-0.06441434,-0.07695918,0.010451753,0.087225,-0.022230057,-0.052760858,-0.059138417,-0.00258127,0.05113956,0.023294983,-0.0038500521,0.0053476677,-0.0044602375,0.062470853,-0.032388423,-0.052864105,0.09226803,0.021893363,0.08350992,0.00266627,-0.035273846,0.08098139,-0.021923736,-0.09688536,0.052420843,-0.003336046,-0.047373153,0.041690204,0.04717766,0.022510016,0.057152756,-0.043101072,-0.0017959336,0.025783101,0.049098033,-0.067204304,-0.008246663,-0.024427215,0.1474801,-0.0321862,-0.045603126,0.006668147,0.11298975,0.02805421,-0.054443773,-0.066073,0.04566867,0.005791953,-0.043267637,-0.0025639348,0.015951212,0.01090816,-0.004876217,-0.059116658,0.0048249154,0.025635853,-0.05937826,0.020762565,0.0018012864,0.0708964,-0.0306358,-0.026483541,0.03749814,-0.0137725,-2.0984422e-33,0.12691799,-0.092451565,0.044492304,-0.048006963,-0.0011733001,0.0385522,-0.051499255,-0.053783633,0.057090737,0.022178369,0.010569407,0.051972993,-0.0006583472,-0.0056747757,0.05471369,-0.02730704,-0.006447695,0.07441785,-0.040061202,-0.03156287,0.04451644,-0.0018232393,0.05295985,0.0008106319,0.090998344,-0.008997457,0.006644589,0.05394252,0.078251064,0.050072353,-0.068870515,0.02890506,-0.008401886,-0.11223455,0.009886247,0.055204,-0.042154178,-0.01119944,0.018777663,0.033860553,-0.034467302,0.034695316,0.020313678,0.057833787,0.017488714,0.13658173,-0.08145987,0.02383517,-0.05392254,-0.07609126,0.04329449,-0.016325377,0.02196501,-0.059893437,0.028666794,0.02289998,-0.03616293,0.006809145,-0.051466994,-0.014506618,-0.030762237,-0.08392357,-0.050766,0.0051358095,0.022594554,0.035756957,0.07588696,-0.011223934,-0.007633346,0.024205614,0.06845919,-0.04146418,0.020323476,0.060466066,-0.08216919,-0.0027072555,-0.053795688,-0.008680606,0.0200964,-0.031270795,0.06256091,-0.025742952,0.029208796,-0.074265905,-0.039781373,-0.11971703,0.0056761964,0.15762562,0.03181682,0.011799888,-0.09559317,0.055761855,-0.012435563,0.023969498,0.047468256,-4.5175966e-08,0.017517252,-0.025254393,0.029283855,-0.048589624,0.0113429325,0.055087496,-0.009122306,-0.010233966,0.09931903,-0.010997421,-0.024642063,0.11502687,-0.0094756335,-0.007455414,-0.0495115,0.033055585,0.026248682,0.022465074,0.015109568,0.06659319,-0.09917847,-0.018078264,-0.096739896,-0.02816351,-0.027889682,-0.09373268,0.023008103,0.077879116,-0.031534653,-0.041597266,-0.004875025,0.014055911,0.039737303,-0.0654086,-0.086401016,0.06495106,-0.038485892,-0.012784721,0.042141862,-0.00978387,0.044851568,0.038867816,-0.07031089,0.008821603,-0.03228281,0.019425508,-0.004442855,-0.008439028,-0.03057373,0.0568156,0.007854739,-0.029392116,-0.0022876682,-0.058123298,-0.11540274,-0.012783439,0.016253084,-0.088377506,-0.009097646,-0.08856346,0.0066786474,0.035562858,0.19591889,0.042560488 +4.3.2.8,"The enzyme, found in vertebrates, has no activity toward alpha-(gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.",384,1.0,-0.03415637,-0.10619938,-0.044883262,-0.041377205,0.045293853,0.043552507,-0.015697258,0.015466929,0.030730525,0.05555263,0.057838604,0.015817078,0.0015973841,0.071251675,-0.02370956,0.083410494,-0.0692426,-0.0889452,-0.02416321,-0.040313054,0.0072622425,0.047196083,-0.033358656,0.0019471461,0.021432653,-0.013029803,0.052180953,-0.07789791,-0.014109211,-0.033786677,-0.035733115,-0.089147456,0.018012939,-0.028299687,0.062503204,0.08145726,-0.10496456,-0.053815566,0.06333815,0.038713485,0.00036160107,-0.028403604,-0.029980246,-0.061516464,-0.032518573,-0.040616896,-0.013414351,-0.034492347,0.0465601,0.041946005,-0.00026832052,-0.088665344,-0.03581403,0.042699464,-0.065396525,0.07033145,-0.07545967,-0.030069327,-0.044967838,0.10081488,-0.042274736,0.055695612,-0.03304811,0.001096727,0.023541788,-0.00076483964,0.055346806,-0.082503706,-0.025006495,-0.08435611,-0.066004895,-0.10264719,0.01290715,0.022028886,-0.054904625,-0.059266362,0.0076465267,0.012557811,0.038081784,-0.07174725,0.055180233,-0.040658392,0.01807287,0.07713696,0.025298914,0.04517319,-0.0109446775,0.05006729,0.099479444,-0.016154965,-0.00964473,0.01344042,-0.050181605,-0.04052758,-0.030104777,0.0012584453,-0.018110957,0.0034435634,-0.009722151,0.023052234,0.039754987,0.0740814,-0.082333244,-0.074090466,-0.07424281,0.0432631,0.0009131909,0.059940346,-0.023368366,-0.044794798,0.027436843,0.016392855,0.023491668,0.03345391,-0.03391668,0.03699884,0.02234484,-0.035505004,-0.04024079,-0.05966163,0.020631246,0.018607806,0.09197418,0.07921088,-0.03974243,0.08246224,-0.03019735,-5.93199e-35,0.06483997,0.05767167,0.010773282,-0.052692857,-0.02200729,0.061447147,-0.090223856,0.03275693,0.038492963,-0.065831386,-0.08435529,-0.041143857,0.047307353,-0.03245519,0.04431351,0.005138496,0.017348232,0.0152075635,0.028645055,-0.004086349,0.01698133,0.06746582,0.043183886,0.03368565,-0.009721091,0.08213105,-0.045830306,0.021146476,0.03620225,0.011017827,-0.07812403,-0.061320502,-0.088064335,0.04091042,0.038679466,0.023529468,-0.0661113,-0.06817103,0.037096884,0.100114055,0.016152645,-0.007884154,-0.008474642,-0.025172701,0.04706671,-0.040379513,-0.016046073,0.099199094,-0.04375688,0.01656127,0.036683194,-0.04902438,0.058707822,-0.04127976,-0.09838464,0.073399566,-0.008924308,-0.029085947,0.030318206,0.05359804,0.021915246,0.02006344,-0.007537552,0.00988368,0.045870703,0.019617053,-0.06404509,-0.063544154,-0.03414873,0.08755928,-0.02638304,-0.013771625,0.073914245,0.05669858,0.07575086,-0.07146101,-0.069352284,0.050106555,0.03278364,-0.015792377,0.026085,-0.01872455,0.04346729,0.022478733,0.041540902,-0.0114816,0.059813775,-0.05009269,0.02147439,0.02005435,0.037237242,-0.06956651,-0.020485973,0.009359152,0.035313267,-1.2287083e-33,0.09733751,-0.08973039,0.0021485812,-0.039979886,-0.031454727,0.013365144,-0.00769678,-0.071535595,0.021816,0.013961897,0.030103918,0.082993045,-0.011849487,-0.039657727,0.06114866,-0.053769734,0.028198007,0.07618702,-0.03487099,-0.068801574,0.05439232,-0.010161765,0.035633095,0.022237757,0.09360367,-0.009567817,0.0225783,0.0524077,0.08823935,0.028453557,-0.092209265,0.03279809,0.0056302417,-0.12844175,0.034319602,0.08824503,-0.04682721,0.007414527,-0.0022771282,0.042556923,-0.046929818,0.05983598,0.045549158,0.015395353,0.017350953,0.11307844,-0.05753151,-0.01614041,-0.07304989,-0.027318584,0.0831093,-0.03107104,-0.0061284234,-0.0767104,0.0045042904,0.044589486,-0.038249135,0.018649653,-0.018815756,-0.009212263,-0.04148828,-0.035876885,-0.023929086,0.004724908,0.039172962,0.02984458,0.039843395,0.012811023,-0.029011158,0.00020533879,0.07900819,-0.06792073,0.033400733,0.06706834,-0.023980698,0.035252288,-0.028740961,-0.07430814,0.04962619,-0.10555293,0.024881857,-0.04806245,0.036728084,-0.06736711,-0.028106475,-0.08931641,-0.020941567,0.14870863,0.045805253,0.0059843794,-0.034907937,0.010318484,-0.012625361,0.04485776,0.12376976,-4.5393104e-08,0.02452256,0.0049582827,0.0075147804,-0.0079461355,0.025852127,0.030166116,0.012811665,-0.027570868,0.07265588,-0.036611665,-0.040121745,0.06829317,-0.020449463,0.050005503,-0.07369966,0.06478727,-0.0024697222,0.034678243,-0.036789667,0.05347222,-0.08279949,-0.002881774,-0.08066545,-0.018697025,-0.027307268,-0.13136388,0.016167378,0.11071358,-0.03994518,-0.06115576,-0.023407156,0.03368687,0.036454484,-0.09527254,-0.079264246,0.040079273,0.024367036,-0.031365033,0.042307742,0.020278279,-0.0059671425,-0.0026752017,-0.030480912,0.008206495,-0.021525795,0.019332048,-0.006657211,-0.003790357,-0.020466365,0.04052255,-0.004321889,-0.019394696,-0.006722369,-0.09498179,-0.062450487,-0.06029891,-0.013176427,-0.07698594,0.039572574,-0.0974597,-0.0020723685,0.029183496,0.19129306,-0.033625618 +4.3.2.9,"The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.",384,1.0,-0.052540924,-0.06427489,-0.037593264,-0.021624735,0.054115664,0.06602757,-0.054457143,0.037848983,0.042476892,0.058997333,0.07460015,0.0058169095,-0.021265076,0.049822237,-0.01729818,0.077461995,-0.09346767,-0.032672275,-0.035031367,-0.06015137,0.07451744,0.08529677,-0.059637357,-0.025203956,0.05621226,-0.0067559355,0.037721865,-0.0404989,0.023072507,-0.04498663,-0.038297616,-0.037836935,0.024514722,-0.027364107,0.004568151,0.06463899,-0.09205448,-0.07627949,0.11920603,0.013062994,0.032288577,0.0050545502,-0.029147862,-0.11960677,-0.036834124,-0.020609263,0.02584084,0.003690195,0.02654435,0.021868113,0.013600583,-0.0900302,-0.04174134,0.021398017,-0.039520513,0.0022223787,-0.046812907,0.014378597,-0.008139589,0.06846105,-0.0076255407,0.059379745,-0.015236143,0.02546444,0.0028131148,-0.045621958,0.0112236,-0.062008414,0.028372923,-0.10255546,-0.0659828,-0.12717041,0.03884372,-0.011568459,-0.004703162,-0.06257603,-0.004584438,0.022204751,0.0032507489,-0.056986265,0.07974597,-0.022542158,0.03606069,0.026752701,0.020212945,0.03928059,-0.00865373,0.04551079,0.07465432,-0.019741338,0.026210168,-0.023070619,-0.06891679,-0.042040862,-0.040471703,-0.0037488288,-0.0013252479,-0.02581004,0.0023684467,0.01671645,0.049034733,0.07599197,-0.06661939,-0.100314274,-0.038144045,0.04188189,-0.005637286,0.054038297,-0.011821379,-0.050677396,-0.010051787,0.04470441,0.013041885,0.02168282,-0.028186226,0.038476042,0.022749707,-0.05315904,-0.060953878,-0.037943564,0.050229345,-0.013945169,0.056770317,0.06558615,-0.033947255,0.106573544,-0.07106497,5.0832518e-34,0.0525874,0.00459976,-0.009339169,-0.031103592,0.040383674,-0.031135727,-0.059892386,0.011048238,0.021864278,-0.054551676,-0.0919723,-0.04897327,0.033426467,-0.038127393,0.03423639,-0.009524324,-0.00620514,-0.012850552,0.058944087,0.017760169,0.0079418775,0.059516296,-0.004368074,0.061600372,-0.01710267,0.07388507,0.0365223,0.021732543,0.05546021,0.0017364917,-0.057106856,-0.11892667,-0.080556035,0.006546096,0.058358632,-0.010941887,-0.042415887,-0.078286946,0.029925605,0.075351425,0.024588505,-0.023221144,0.0007543461,0.024791861,0.04671657,-0.017195564,-0.051496312,0.11499779,-0.018420821,0.03445803,0.054629426,-0.059814297,0.063858494,-0.032602303,-0.10482504,0.07711792,-0.024603905,-0.020243557,0.035573322,0.044569388,0.018796196,0.0066571888,-0.017548865,-0.004695437,0.030385086,0.040921867,-0.06531439,-0.082651384,-0.03329976,0.10993436,-0.0623779,-0.038877927,0.057154242,0.046221174,0.051125474,-0.051022645,-0.0564119,0.024074998,0.05572897,-0.01600156,0.00062266784,0.022185441,0.022415213,0.014097099,-0.0038588068,-0.06811328,0.010229856,-0.08878186,-0.0081226695,0.00035388744,0.04672862,-0.03453549,0.0014754874,0.010313783,0.041665353,-1.9612778e-33,0.09939763,-0.06856496,0.025992371,-0.01937363,-0.05307426,-0.004899603,-0.047512658,-0.058777854,-0.0054419357,0.01100399,-0.033556134,0.06848407,0.032347567,-0.014299511,0.060024407,-0.029013554,0.041717436,0.040711317,-0.050645437,-0.05118632,0.015935643,0.0050918036,0.07229062,-0.0048967884,0.07489246,0.0057050777,-0.004834917,0.0588394,0.056121115,0.05151514,-0.049558412,-0.0014457438,-0.012928089,-0.11710312,-0.02286512,0.088848926,-0.026487045,-0.030814625,-0.01062343,0.045047335,-0.02322521,0.038567796,0.043676555,0.043961342,0.035001207,0.066876546,-0.075348064,-0.012023665,-0.071264364,-0.057668913,0.0517654,0.015385951,0.013863441,-0.055684224,0.007470471,0.057841167,0.0014396765,-0.0040692817,-0.007977223,0.0038538352,-0.014195911,-0.07322436,-0.023886632,0.03397614,0.014981233,0.022164654,0.07042517,0.0013377874,0.006403155,0.0060909307,0.10593431,-0.023014223,0.029618531,0.04602685,-0.06543301,0.0040673832,-0.034665115,-0.0740773,0.01407102,-0.07316586,0.044059217,-0.066046305,0.030122196,-0.066082545,-0.06280143,-0.14827593,-0.01649857,0.18547735,0.055123318,0.009600259,-0.037898485,-0.017835408,-0.023072662,0.040452816,0.1034248,-4.308922e-08,-0.032861065,-0.05855641,0.023177868,-0.017678803,0.01919562,0.06543909,-0.033530317,-0.04078954,0.06875387,-0.043875568,-0.04034499,0.061899737,-0.063378714,0.03663574,-0.0071856175,0.08236327,0.017457264,0.093158096,-0.036357198,0.072395034,-0.09019303,0.013694202,-0.11174651,-0.0032062805,0.027150795,-0.104142606,0.022137163,0.11983922,-0.031433802,0.00014365267,-0.019256037,0.05503489,0.03483416,-0.07002608,-0.07021971,0.03091567,0.004341991,-0.013553055,0.01897609,0.025251776,0.018347124,0.011284552,-0.057511285,0.0029664568,-0.040544704,0.0091878865,0.012129629,0.010676543,-0.015636854,0.011330576,0.040287953,-0.027365576,-0.0075207297,-0.0747173,-0.07370912,-0.04986264,-0.0064147892,-0.07409902,0.04483072,-0.08514733,-0.049050495,0.090291284,0.20962943,-0.0072709457 +4.4.1.36,"Contains pyridoxal 5'-phosphate. The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-(hydroxysulfanyl)hercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function.",384,1.0,-0.04851924,-0.009801877,-0.06276243,-0.062876314,0.045820996,-0.02294326,0.015925528,0.12384459,0.025510835,0.037177365,-0.010222371,-0.025276244,-0.023341186,0.03464409,-0.0058907964,0.05647233,-0.055345,0.043871775,0.03847738,-0.093803495,0.058062408,0.05470366,0.07028582,-0.022335848,0.02984755,0.029218439,0.078691974,0.022183148,-0.0532654,-0.084088005,-0.05418355,-0.07185607,-0.019154362,-0.047438752,0.03445042,0.06912759,-0.1289658,0.006459607,0.07020774,-0.04643356,0.078803234,-0.045778472,-0.025440156,0.04098339,-0.03667169,-0.011989104,-0.04171444,0.06570509,-0.031151067,0.0051939115,-0.061127845,-0.004564502,-0.017830541,0.021895885,0.0016888075,0.014743562,0.013758807,0.019771356,-0.02353663,-0.009501034,0.11882264,-0.009384777,-0.07438563,-0.005422732,0.008915796,-0.017982272,0.05116335,-0.05427038,-0.001380892,-0.042548552,-0.06810649,-0.045528166,0.0062597767,0.06862027,0.03454229,0.01099189,-0.015751682,-0.0018027811,-0.018209651,0.051600907,0.008464918,0.02377771,0.06293372,0.080279365,0.04085931,0.023122184,0.018131206,0.06785082,0.0069929212,0.052187476,0.032932248,-0.025136095,-0.09114318,-0.02570868,-0.024660265,0.034290094,-0.026431736,0.008007353,0.026325228,-0.04239638,0.007390674,0.039723583,-0.031988718,-0.05850046,-0.08294728,-0.012246797,-0.044017635,-0.012321316,0.03518253,-0.04960931,-0.058561303,0.037792984,-0.0193509,0.012238981,-0.025269227,0.0773017,0.077975325,0.007199239,-0.07819146,0.016378392,0.010697477,-0.013896749,0.0067770947,0.054240875,-0.047754344,-0.07551943,-0.11466965,3.7852226e-33,0.043175995,0.02084386,0.019364657,-0.0057048956,0.030309768,0.07981655,-0.043594703,-0.0240956,-0.06648273,-0.027305154,-0.09255739,-0.10568325,0.0042405087,0.019514704,-0.11334829,-0.05006388,-0.04850799,0.034918077,0.12727442,-0.010705451,0.049055144,0.056257065,-0.07230429,0.03437516,-0.053129867,0.09909977,-0.0015641192,0.10585339,0.042402938,0.013089366,-0.0005062158,-0.089266285,-0.058206845,0.016785366,0.04753884,-0.058202036,-0.047929533,-0.018806376,0.04632662,0.0053792153,0.0038857171,0.01574648,0.037775,-0.0019518917,-0.0027385163,-0.0945365,-0.01833793,0.039794896,0.033723813,0.06783818,0.042724438,-0.068455435,0.095782354,-0.0749762,-0.06797047,0.0052322857,-0.03999664,0.013167093,0.035069507,0.057937,0.06610118,0.01673663,-0.040392973,0.061652537,0.019384844,-0.0143079,-0.012033096,-0.045947842,-0.019177271,0.06454757,0.016824182,0.0033422224,0.039819207,0.011029956,0.021776676,-0.0297223,-0.034383662,0.05216467,-0.016627155,-0.043134913,0.0009803943,-0.06501224,-0.04671476,-0.01455931,0.0127008185,-0.02413024,-0.04308798,-0.06647718,0.024449008,0.012589378,-0.018888872,-0.11174212,-0.10580249,0.04819849,0.011799827,-4.7411155e-33,0.106142715,-0.078810275,0.09107116,-0.051731564,0.016303131,0.023657238,0.080473945,0.079852305,0.057509836,0.04453385,0.12131011,-0.02253764,-0.03492886,-0.064766586,-0.023216298,0.011897948,0.031722225,0.0340425,0.004901193,0.023613827,-0.044319034,0.07881494,-0.0054667625,0.0054639336,0.023068557,0.057566438,-0.020962235,0.055447478,-0.01646895,0.0713081,-0.012016904,0.012081614,-0.048072997,-0.07694802,-0.05788469,0.03115823,-0.033698704,0.0023419857,0.01154622,-0.01046272,0.053890932,0.037067678,0.013382825,0.03867819,0.038171425,0.07201225,-0.06808183,0.03845247,0.0034732767,-0.06826663,0.012369243,0.055148076,0.062345244,-0.003371931,0.046130788,0.007809401,0.024969235,-0.049313597,-0.037797473,-0.020036722,-0.03961766,-0.06632443,0.021174537,0.030960301,0.060645096,0.031844366,-0.0129085975,0.0753874,0.04255511,0.04430374,0.053032182,0.016789228,-0.024436569,0.02844448,-0.08212698,-0.030137537,-0.026822872,0.031297613,0.05578266,0.024268884,0.058728814,-0.0075377813,-0.031271663,-0.15186547,-0.00816084,-0.10550162,0.035445243,0.08634921,-0.012510397,0.05722461,-0.026108056,0.04286451,-0.04739144,0.088921495,0.0629684,-4.387907e-08,0.06821114,-0.12845862,0.012629016,-0.05883953,-0.008199579,-0.036571056,0.008728772,0.047229953,0.07227736,-0.028178036,-0.052035715,0.014125389,0.026293479,-0.030524246,0.06048542,0.040528197,-0.0032755064,0.030204827,-0.013126539,-0.06815842,-0.04213334,-0.0121526765,-0.031596087,0.008354609,0.074635416,0.014178604,-0.018553045,-0.04843503,0.013703872,-0.011949369,0.059160408,0.003354078,-0.033134293,-0.05282008,-0.13186575,0.049811475,-0.055649735,-0.07331671,0.0027017805,-0.012670594,-0.009581683,-0.010691371,-0.056688443,0.042137016,-0.03591144,0.02468886,-0.03727768,-0.01299813,-0.03009518,-0.04852371,0.012065867,0.010121135,-0.069748335,-0.0795156,-0.1446583,0.08236844,0.037848666,-0.008376148,-0.04170435,-0.10223104,-0.018354325,0.0217995,0.19467321,-0.03307071 +5.4.4.8,"Isolated from the bacterium Thauera linaloolentis grown on (RS)-linalool as the sole source of carbon. Unlike EC 5.4.4.4, geraniol isomerase, which only acts on (S)-linalool, this enzyme acts equally well on both enantiomers.",384,1.0,-0.049698677,-0.018760249,-0.13176559,0.008998815,0.06325342,0.07587494,-0.09530396,-0.0004935399,0.063663065,0.0037633446,0.057342622,-0.06538077,-0.043642703,3.509124e-05,0.018853543,0.030339638,-0.026115084,0.008524805,-0.048381176,-0.06114296,-0.022713259,-0.015390244,-0.050683763,0.03528012,0.032710806,-0.079916835,0.011089826,-0.02262869,-0.00036234895,-0.06992055,0.039669212,-0.048962895,0.03042989,-0.072042,0.06622189,0.09170848,-0.042330846,-0.06996276,0.037584286,0.07587012,-0.020026457,-0.07956398,-0.01723664,-0.048021972,-0.04705225,-0.021519063,-0.03409678,0.06791682,0.0037583003,-0.07490519,-0.0788773,-0.03249601,-0.06255742,-0.026861202,-0.024632739,0.00843425,0.020798832,-0.015040464,-0.00069959613,0.02622996,0.052642938,0.032531384,-0.024044253,-0.0056872666,-0.06566789,0.0264433,0.071376264,-0.04334562,0.052312806,-0.015474689,-0.049951058,-0.10773031,-0.052926157,0.05637898,-0.092305236,-0.0029688063,-0.0022477296,0.017984124,0.05350432,0.039530884,-0.0025845822,0.048578855,-0.02083061,-0.027016954,-0.016021302,0.05623458,-0.036896065,-0.011595754,0.06323441,0.06729021,0.07925497,0.018283918,0.04718826,-0.06901088,0.019829057,0.05049734,0.1057519,0.050111476,0.049679417,-0.052660186,0.027675785,-0.010418601,-0.07626001,-0.0444094,-0.100465104,0.01692469,0.011135202,0.03408494,0.008811441,-0.019559544,-0.043830782,0.026563855,0.008488448,0.0125388345,-0.0032326162,0.01953912,0.12927206,-0.046228465,-0.031869642,0.004891795,0.004787531,0.004896717,0.082890965,0.06878089,0.042753123,0.016063422,-0.06764291,2.1186844e-33,0.096938156,0.007292002,0.024434004,0.0033689893,-0.07302306,0.06138639,-0.07897133,0.053585164,-0.12561683,-0.020139933,-0.039790146,-0.04432877,0.01949927,-0.012115089,0.04779318,0.035363495,-0.028029162,0.04352736,0.02364731,-0.018284423,-0.036866263,0.051312607,-0.020611573,0.006440763,-0.027520055,0.07487252,0.030239772,-0.08206828,-0.0055754054,-0.03055848,0.09788796,-0.022082908,-0.063911505,0.08224957,0.031448353,0.004412809,-0.06377169,0.050774384,-0.0410059,0.010408541,0.06645436,0.14142524,0.042325024,-0.10105359,0.06703788,0.005246437,-0.07772952,0.022016283,0.1319395,-0.011555894,0.03300278,0.018525431,-0.010388037,-0.0076473644,-0.016314507,0.052687388,0.020274866,0.053850688,0.05023648,0.021436723,-0.0022054038,0.08907685,0.028498229,-0.0700516,0.07212172,0.041604213,-0.1115252,-0.046381995,-0.006063676,0.041625686,-0.014741496,0.011883294,0.050808586,0.045386523,0.018779125,-0.038278088,-0.13149434,-0.012911923,-0.015354664,0.0074157505,-0.03663041,-0.032525923,0.03329315,-0.009553537,-0.0101277325,-0.050219845,-0.048282154,0.020381372,0.0044139153,0.07589108,0.0525751,-0.06522867,-0.09647889,0.033954144,0.013880081,-2.4842655e-33,0.10797623,-0.1064834,0.043339405,-0.028715864,-0.026050026,0.042196333,-0.07746374,-0.032494858,-0.0013060864,0.077801995,0.11001843,0.04050945,0.08787159,-0.003374188,0.023012297,-0.03816239,0.0641141,0.0138530135,-0.015871407,-0.021916904,-0.03714922,-0.039299566,0.024485331,-0.05355135,0.061465245,0.026549106,-0.0061753015,0.036887996,0.038378067,-0.020212123,-0.046646543,0.025509132,-0.049219795,-0.08124887,-0.07108612,-0.0020571777,-0.09301171,0.057538386,0.015725758,0.011162498,-0.064405516,0.058975123,0.0037276498,0.04849638,0.03220406,0.038021967,0.020127786,-0.030038623,0.008324689,0.013266127,0.055909496,-0.022866866,-0.034095455,0.009949367,0.012845062,0.00035234026,0.028945247,0.056695342,-0.007795461,-0.08920651,-0.004681633,0.05639201,-0.062236052,-0.057886146,0.038803555,0.11733653,0.008231657,0.07911867,0.012769226,-0.0976851,0.133632,-0.01872114,0.008185464,0.006001864,-0.0083042225,-0.04866953,-0.05964052,-0.10206287,-0.010488294,-0.03935082,-0.012236331,-0.043821577,0.00037777377,-0.04498136,0.011865224,-0.069022626,0.02944735,0.020163665,0.0081848595,0.060111586,-0.034209598,0.01510071,-0.0651058,0.06839944,0.15958133,-3.5277022e-08,-0.055331696,-0.022909112,-0.043465998,-0.00051399425,-0.023558626,0.02821219,0.051147647,0.053338006,0.033693712,0.02338484,-0.014316817,0.045796167,0.026126144,0.029648684,0.11592478,-0.020281374,-0.035836704,-0.041355018,-0.00073068164,-0.04502328,0.0092610475,-0.025515636,-0.014687357,-0.020261843,-0.05736238,-0.08113229,0.05410449,0.0015163987,0.0864449,-0.042185757,-0.029528575,0.049875148,0.049996097,0.02672849,-0.014769468,0.0029155936,-0.06987582,-0.022780435,0.00052039407,0.04476229,-0.05040735,-0.056731634,-0.08321591,0.009180678,-0.012088971,0.017138693,-0.0007318862,-0.05062331,0.025135975,-0.012543548,0.05698912,-0.07182662,0.036454864,-0.04283053,-0.03317313,0.06160067,-0.009115046,-0.060666017,0.041499626,0.024824653,-0.013251048,-0.07075218,0.118354246,-0.0025779218 +5.4.99.65,"Isolated from the plant Lycopodium clavatum. The enzyme does not act on (3S)-2,3-epoxy-2,3-dihydrosqualene and does not form any alpha-onocerin.",384,1.0,-0.031068733,-0.0622366,-0.072938964,-0.062634505,0.08901404,0.051471822,-0.07634718,-0.045841992,0.01383408,0.017001491,0.072989516,-0.09527315,-0.050870195,-0.009711843,0.0075033745,0.036712322,-0.042617407,-0.001354452,0.03602197,0.07443711,0.066615865,0.012151787,0.055288114,0.031980693,0.051042367,0.037316374,0.018239144,-0.04545915,0.026208932,-0.09492487,-0.05366651,-0.009409358,0.06498703,-0.060673635,0.05808324,0.031035325,-0.048124652,-0.037134886,0.02878043,0.056050114,0.011957985,-0.009662717,0.008021853,-0.06687303,-0.1090082,-0.026775975,-0.094944604,-0.046027344,0.012790602,0.030888282,-0.0070353984,-0.11274243,-0.0131931035,0.028956963,-0.043752965,0.004340986,0.025503598,0.13502733,-0.010283918,0.041150905,0.09607587,0.0069568604,0.033430006,0.0033014137,-0.0017658226,-0.01581979,-0.08297167,-0.015343117,0.04545623,-0.04765193,0.008032049,-0.033254582,0.02063262,0.025298724,-0.015273468,0.032174833,0.010368789,0.017889248,0.016433002,0.004582408,0.010088269,0.024433058,-0.0074180258,0.10015681,-0.009691092,0.041775376,0.006505054,0.023005828,-0.00857098,-0.0020530124,0.07958326,0.014542427,0.0027206156,-0.02282947,0.00031530784,0.067752674,0.0108589595,0.001014889,-0.0045343186,-0.00053973345,0.07377748,0.0076075154,-0.009487322,-0.13673314,-0.0671448,0.04914139,-0.08210199,-0.101377815,0.048938017,-0.01918536,-0.026990723,-0.01511834,0.041713245,-0.01057833,-0.019194497,-0.0067953244,0.019357162,-0.017695192,0.023734996,-0.01957278,0.024554677,-0.03906382,0.094549365,0.03827578,-0.078392096,0.053251665,-0.05428381,1.7454276e-33,0.08952196,-0.023473507,-0.005452758,-0.016496385,0.010310901,0.0059010424,-0.026369791,0.025830433,-0.101605035,-0.08176581,-0.12044674,-0.043712027,0.024798887,-0.017944604,-0.0072233863,-0.046988018,-0.0073153973,-0.027203431,0.037005186,0.01641033,0.06778115,0.007189147,-0.115217716,0.03451192,-0.053723592,0.02668819,-0.005221405,-0.06090423,0.04700333,0.0061141974,0.048439823,-0.09351003,-0.049888764,0.039453853,-0.009434759,-0.0140921585,-0.0491595,-0.04166358,-0.028224269,-0.0019506764,0.041380085,-0.015064833,0.028571885,-0.045824666,0.11232249,-0.053371936,0.012399608,0.079620026,0.071623035,0.022672733,0.0045508267,-0.00263386,0.01393729,-0.030619726,-0.035257876,0.020773277,-0.018471472,0.035635572,0.051289182,0.021208182,-0.017350951,0.10251617,0.015184354,-0.017534504,-0.039367653,0.049795225,-0.10391189,-0.030194627,-0.035942364,0.0017830621,0.027092572,-0.05274676,-0.0044809477,-0.0063907215,0.081653364,-0.03477938,0.009981949,0.017979093,-0.019356625,-0.032497022,-0.0071238456,0.009077169,0.07104704,0.046345174,-0.11107256,-0.031213792,-0.063446924,0.030353995,-0.07529832,0.09218263,0.0070601027,-0.033803545,-0.09315942,0.05420893,-0.05571221,-1.8460665e-33,0.11869553,-0.06632349,0.08833471,-0.085351385,-0.0603125,0.12227931,0.009757736,-0.008478508,0.017114867,0.033610642,0.06140714,-0.0035448552,0.043931074,-0.06913768,0.067653686,0.08139278,0.046325732,0.080642365,-0.010486799,0.005718722,-0.02523642,0.0044094324,0.02194662,0.04449725,0.0064369966,0.00037457465,0.08815983,0.041822884,0.004756563,0.014075624,-0.02701288,-0.023773478,-0.053183015,0.037966404,-0.06865862,-0.033431046,-0.05440909,-0.06554326,-0.044992108,0.012627443,-0.042083744,0.013382664,-0.021019222,0.05435577,0.07065771,-0.013453359,-0.04927017,0.011864185,0.04817358,0.07444418,0.0024346074,-0.026718618,0.076524824,0.025375037,0.026854124,0.010166228,-0.050946858,0.02434472,-0.027661841,0.011375506,0.033477202,-0.030831823,-0.03865587,0.080550715,0.049959615,0.1263451,-0.01831674,0.13021739,-0.025483966,-0.058052067,0.08961036,-0.020521965,0.070259534,0.0074892123,0.025791943,0.03144086,-0.025562441,-0.088096134,0.0004857651,-0.062433567,0.02713599,0.02049144,0.023623083,-0.08891282,0.0040505095,-0.026603462,0.033267614,0.05818837,0.023998894,0.06130955,-0.032481737,0.06839858,-0.079872556,-0.004090375,0.20920108,-3.32543e-08,0.08240096,-0.007504197,0.07153953,-0.046738677,0.005483388,-0.05642973,0.014981503,-0.031599674,-0.0042432146,-0.002096674,-0.048243996,-0.027055262,-0.017395623,0.046825882,0.09546505,-0.0123350285,0.066460595,0.060427465,-0.028091216,-0.01941438,-0.08018236,0.01189504,-0.031034749,-0.0074637337,-0.045956224,-0.014265968,0.02036188,0.017326614,0.016226135,-0.01598693,-7.071754e-05,0.035485197,-0.06873435,-0.109344706,-0.07539598,0.0612981,-0.016867,-0.03832304,-0.10064141,0.035617832,-0.025570974,-0.002908064,0.02857015,-0.008688364,-0.033997256,-0.026665417,0.001303792,-0.02491029,0.020678874,0.0051577943,0.02441361,-0.0030087247,-0.0029888174,-0.06235914,-0.09612584,-0.025567578,-0.004981673,-0.031456217,-0.061394952,-0.051163502,-0.03709434,-0.015096793,0.17501482,0.04848698 +5.4.99.66,Isolated from the plant Lycopodium clavatum. ,384,0.99999994,-0.004225255,0.01975402,-0.08684044,-0.03141506,0.06573125,0.04613803,-0.053539846,-0.030251242,0.0024632134,0.0014302661,0.09363475,-0.05843987,0.03247663,-0.046272952,-0.0054173353,0.050156217,0.034081124,0.0048531354,0.022228435,0.12007365,0.0681431,0.079568505,-0.008749035,0.01923818,0.032186095,0.020000463,-0.035142347,-0.026121693,0.0151173165,-0.11132326,-0.075209506,0.04635455,0.055629157,-0.061625216,0.055583466,-0.012111659,-0.04481237,-0.020264104,0.11862515,0.06922556,-0.031439256,-0.039267723,0.029100006,-0.08818405,-0.08540613,0.013835977,-0.080443285,-0.020984838,0.023406964,0.026743367,0.013309517,-0.06522409,-0.07100793,0.027186714,-0.008396254,-0.03522478,-0.018534366,0.0897997,0.03504797,0.042871732,0.05377505,0.0488154,0.001343807,0.018023435,0.014877555,-0.07597293,-0.10681589,-0.0061686877,0.11025385,-0.06640866,0.0457295,-0.045837466,0.029752074,-0.021428617,-0.069031574,0.003575751,0.015217608,0.036765695,-0.017572992,0.08134936,0.010628882,0.070868246,-0.0012545235,-0.0011129051,-0.03881691,0.0048549003,0.074604385,0.05285719,-0.054394476,-0.055229776,0.06936922,0.009574293,0.00065708254,-0.04102124,-0.012744337,0.06642614,0.032564055,-0.018929986,-0.0046165213,-0.01537502,0.06944748,-0.061421115,0.032433357,-0.13577434,-0.04464222,0.022190528,-0.06429137,-0.077598415,0.08783885,-0.03595847,-0.044746332,0.021163093,-0.04913504,0.006896952,-2.6718214e-07,-0.0057246606,0.06858077,0.011475465,0.014284683,-0.01955232,0.018977327,-0.05114097,0.119557574,-0.0060559353,-0.021110486,0.03735914,-0.04888558,3.8625922e-34,0.10065037,-0.107166395,0.010750014,-0.008971454,0.024080297,0.01714901,0.018526835,0.007862761,-0.08802983,-0.05647394,-0.07239163,-0.027866984,0.021115512,0.014186058,-0.062807724,0.027862517,-0.046150733,-0.018055024,0.062063042,-0.010162154,0.016099118,0.0235097,-0.052131448,0.04074736,-0.08019376,0.012968578,0.028838541,-0.07245721,0.019785948,0.03824486,0.06313909,-0.059462395,-0.00982837,0.022849713,-0.008656164,0.013397627,-0.03925944,-0.05346086,-0.050675515,-0.022861855,0.06545699,-0.02296528,0.015755847,-0.0121231405,0.05622819,0.004045379,0.011023654,0.03226327,0.021122707,0.021479057,-0.060163125,-0.007631525,-0.021903846,-0.0060705747,-0.054446515,-0.0017369118,0.009463151,0.045137644,-0.010558129,0.039633054,-0.016794726,0.14258908,-0.019616747,0.015586037,0.021557903,0.006829913,-0.122350655,0.010688677,-0.012951797,-0.07311892,0.006640845,-0.0973055,0.0065593347,-0.0354149,0.030466458,-0.038986497,0.042017635,-0.0322136,-0.08783642,-0.0018329688,0.022212686,0.014012561,0.08493326,0.008214777,-0.088047504,-0.03600918,-0.07874747,0.027932903,-0.05048768,0.037981786,-0.036962893,-0.012750953,-0.08094533,0.0142328795,-0.044978533,-1.0336578e-33,0.1406885,-0.019507162,0.079484634,-0.014962911,-0.026115669,0.05523554,-0.011186515,-0.0045321565,-0.031491674,0.028666833,-0.05611325,0.018902494,0.072674505,-0.020087505,0.08845568,0.08398568,0.06772131,0.03703096,-0.06613666,-0.005389999,-0.08568169,-0.010583341,0.047861416,-0.025010811,-0.003907921,-0.0023306562,0.06485648,0.00093625684,-0.024068328,-0.016301721,-0.015060802,-0.007801497,-0.065178424,0.036538534,-0.0608395,-0.0540809,-0.071530245,-0.10343082,0.01819999,0.032020085,-0.021273872,0.024004543,-0.023210125,0.012087152,0.07516753,-0.10134813,-0.02060868,0.015402146,0.038063,0.09027101,0.024195341,-0.0013477495,0.051058713,-0.011983015,0.036606956,-0.028153509,-0.05038304,0.083945416,0.012601208,0.0043958155,0.04242717,-0.0036369585,-0.08739688,0.04073522,0.07962352,0.14597587,0.023897592,0.09423285,-0.07733233,-0.013336584,0.08305559,0.037914332,0.03633605,0.017958704,0.024989448,0.027876902,-0.048248917,-0.086063005,-0.01642174,0.01778655,0.032290272,-0.031267524,0.058503244,-0.09258437,0.03379194,-0.030848747,0.010236004,0.017764559,0.016251097,-0.0017309511,-0.026083225,0.028970707,-0.09246252,0.025713013,0.1947217,-1.7020344e-08,0.07961102,-0.015191353,0.004069713,0.019611046,0.0568174,-0.048082344,0.013074088,0.027226998,0.0038231066,0.042586785,-0.03130819,-0.020784466,-0.009106451,0.07682874,0.09126266,0.025233151,0.096382424,0.021489222,0.00048034606,0.03369518,-0.09335095,-0.058142867,0.02945711,0.02292488,-0.07030971,-0.023984348,0.0829079,0.020912485,0.0734657,-0.016270783,-0.022182712,0.020256,-0.0700225,-0.085342705,-0.04852943,0.051849708,-0.0032626365,-0.0083091315,-0.04271862,0.03729688,-0.002825209,0.00057104084,0.034814563,-0.020080632,-0.065616146,-0.02601874,-0.031904817,0.019007068,-0.04800499,-0.041029193,-0.016913401,-0.031018512,-0.0045833373,-0.0068961447,-0.04697536,0.0026319532,0.01591228,-0.030672535,-0.034193087,-0.00011243311,-0.10233866,0.07034916,0.122786924,0.047769506 +5.5.1.28,Isolated from the hallucinogenic plant Salvia divinorum (seer's sage) and the medicinal plant Tripterygium wilfordii (thunder god vine).,384,0.99999994,-0.00082313636,0.016093744,-0.094751574,0.02391749,0.07346333,0.10961973,0.012578478,0.015886195,0.011739351,-0.0395481,0.034693494,0.022061698,-0.040541373,-0.04344957,-0.015896019,0.061806027,0.017429758,0.009540095,-0.00419646,0.015599793,0.07213624,0.052260164,-0.011350191,0.04185516,0.036251288,0.029977016,-0.013565403,0.038188722,0.015744306,-0.14074112,0.054755386,0.050792474,0.061228532,-0.038940523,0.015276276,0.004318882,-0.008745792,0.013449371,0.063614674,0.03243035,0.0027433129,0.016120125,-0.03626624,-0.038320437,0.0016863648,-0.047695603,-0.06700216,0.034199663,0.08390553,-0.007663576,-0.048975065,-0.049177695,0.026817549,0.033427488,0.012634434,0.0010231581,0.06270568,-0.008658768,0.025245382,0.0646833,0.026012553,-0.009848687,-0.009452511,-0.06866854,-0.10871078,0.0095824795,-0.06765108,0.0297933,0.10139732,-0.11375381,0.019540077,-0.03504587,-0.006178663,0.021273416,-0.02804677,-0.0076839896,-0.02219589,0.028765455,-0.03705092,0.0036824439,-0.004203006,0.06624441,0.06306848,0.0450197,0.030144364,0.037672497,0.0003290987,0.077576846,0.048588917,-0.035980694,-0.014821663,-0.007947206,-0.050075933,-0.06391733,-0.023870265,0.04895104,0.014785037,-0.096905656,0.0013819415,0.025378354,0.092935376,-0.032985013,0.010255725,-0.12845705,-0.030442752,0.09923454,-0.055690963,-0.020033995,0.068764724,-0.04643343,-0.017886683,0.023027023,-0.014801228,-0.041729845,-0.03619271,-0.02800431,0.0229785,-0.016970046,-0.072097845,-0.044595003,0.050192017,-0.009866604,0.1231816,-0.008824329,0.0015188552,-0.028870817,-0.047594514,2.4564122e-33,0.02370845,0.011633901,-0.02412326,0.009877361,0.040951807,-0.051091053,0.020799603,0.04734251,-0.076605864,-0.1232658,-0.09072897,-0.088993855,0.0041823294,-0.02957353,0.013974078,-0.05599971,0.014409696,-0.07554768,0.08213937,-0.050758485,-0.032481782,0.048200376,-0.081112616,0.04686978,-0.0941145,-0.003851511,0.056678887,-0.036369797,0.1193053,-0.004196712,0.074731104,-0.027072646,0.025142558,0.009048427,0.026452474,0.030629283,-0.113906235,-0.029668719,0.0077621615,0.055112682,0.040809985,0.069873445,0.026208567,0.050230112,0.019151786,0.019550333,-0.03234804,-0.008601464,0.0822227,-0.010248868,-0.06359498,0.026539402,0.038644023,0.011191588,-0.09178133,0.003273647,0.006234474,0.054065865,0.047643725,0.032154355,-0.01497723,0.036000956,-0.028126651,0.00995842,-0.03337126,0.0039507467,-0.102228165,0.009409308,-0.04289317,0.013272665,-0.01140849,-0.026855607,-0.026480023,-0.0056518456,0.034355156,-0.046184275,0.012603777,0.06333577,0.016994253,-0.037158165,-0.05330937,0.02659411,0.006967537,0.098268464,-0.057313245,-0.009785202,-0.064347155,0.0013770666,-0.035119142,0.014314248,0.037461247,-0.006056317,-0.032281186,-0.011115439,0.003841944,-1.7038278e-33,0.09033575,-0.009239144,0.089640886,0.036840726,-0.014362192,0.110508785,-0.06282964,0.04478665,-0.008770615,0.02666391,0.019581547,0.0050854394,0.026674274,-0.08207317,0.0072695105,0.06445004,0.09772713,0.15833533,-0.09002601,0.019607726,-0.057889376,0.05159012,-0.051775366,-0.1218694,-0.02829833,0.039297953,0.057575706,-0.041801855,0.080774955,0.030526757,0.07981471,0.025051668,-0.09860076,-0.079046085,-0.07230727,-0.015687255,-0.0670787,-0.07801223,-0.03618911,0.060253374,-0.028807973,0.061793793,0.05714682,0.025340063,0.095804736,0.030440392,-0.052700136,0.03944177,-0.076825194,0.05376072,0.047183253,-0.02135728,-0.018640421,0.010373511,-0.0032928349,-0.09103561,0.04378183,-0.00399434,-0.02075633,-0.0722898,0.030978382,0.020495832,-0.051138986,0.03359685,0.010353955,0.07097098,0.04297762,0.05558789,-0.059683803,-0.002016147,0.009795915,0.004939268,0.035540737,0.06780392,0.016102158,0.077563,-0.038722258,-0.024148863,-0.007443874,0.0111022405,0.036341093,-0.031084074,-0.0084465975,-0.07720038,0.010925655,-0.084795706,0.02829911,-0.004955449,0.010924798,0.025092749,-0.017308129,0.013992321,-0.06844613,0.0087691555,0.15970358,-2.714127e-08,0.047918014,-0.089420795,-0.055298965,-0.036234383,-0.019148935,-0.06390106,0.04802706,0.055190407,-0.003100304,0.011693767,-0.02003844,0.03017034,-0.01298891,-0.039395183,0.029869087,0.010925635,0.11318924,0.056996275,0.0016742905,0.025545862,-0.01805585,0.010971297,0.027224682,-0.014369843,-0.05943814,-0.07053497,0.051305927,-0.03963582,0.07093226,-0.06634995,0.05915459,0.07844161,-0.033899065,-0.08396309,-0.024075752,0.06869933,-0.026947487,-0.01120444,0.05541194,-0.0145455,0.012251483,-0.06955925,-0.0075091957,0.0013756874,-0.012161137,-0.06504693,0.016729925,0.010496199,-0.015485556,-0.061777726,0.004861929,0.0020422407,0.059288327,-0.06392341,-0.12334313,0.026334567,0.024850871,-0.10018729,0.010107177,-0.13947298,-0.014360426,-0.021255165,0.06838984,0.06212192 +5.5.1.29,Isolated from the bacterium Herpetosiphon aurantiacus.,384,0.99999994,-0.07168087,0.022292994,-0.07056518,0.004905471,-0.036368936,0.034221753,0.011758656,0.055720057,0.0053852727,0.035711,0.012731792,-0.08056944,-0.0073211356,0.062048033,-0.07320638,-0.00421641,-0.037380733,-0.029102257,-0.015480688,-0.0003970297,-0.007890496,0.0822473,0.007383667,-0.03764311,0.043041836,0.033436652,-0.04628067,0.04583371,0.028150413,0.0011020614,-0.06782109,-0.05952694,0.03167438,-0.04811836,0.08207946,0.05112286,-0.0426574,0.0121989595,0.13563456,0.022639418,-0.02162432,0.044494435,-0.02587782,0.015427399,-0.023045085,0.032312892,-0.07493104,0.026460988,0.07607523,0.0160272,-0.0062707085,-0.020982495,0.0039790547,-0.0036461982,-0.08323505,-0.07070697,-0.009618272,0.01344464,0.010429869,-0.04760498,0.09833382,0.015298821,0.049556185,0.06949534,0.0019617188,-0.0040285615,0.023846224,0.008210217,0.10288853,-0.020499082,0.057206262,0.008431832,0.02839204,0.06967347,0.012523282,0.058239777,0.03546454,-0.023488551,-0.0044141016,0.036628846,0.02469326,0.026709551,-0.013789626,0.059082787,0.00981094,-0.012916932,0.04574138,0.008897009,-0.036710557,0.03229134,-0.036443446,0.0027195555,0.014410456,-0.11462211,0.009762922,-0.028715212,0.020375624,0.006321297,0.055716448,0.0043066926,-0.020294774,-0.025202358,0.023204805,-0.0639457,-0.03377854,-0.0041831904,-0.06360916,-0.09188406,0.10006461,-0.007684048,0.0035482238,0.017313674,-0.0997395,-0.052737925,0.080726296,0.076673925,0.039819837,-0.06251116,-0.040013753,0.00269118,-0.018533459,-0.11287355,0.07664084,0.0029644377,-0.036655635,-0.012452473,-0.054937795,8.5248853e-35,0.021115715,-0.0351726,0.04375735,-0.06657108,0.06408212,0.08186928,0.047513213,0.00033179997,-0.09601441,-0.00012839216,-0.10408057,-0.023929076,0.06581301,-0.037472118,0.020613015,0.03339102,0.036147255,0.00019306893,0.087685145,-0.039125107,0.03235644,0.11278859,-0.0040663253,-0.02297638,-0.0037873802,-0.00034002267,-0.0005638998,0.0033954163,0.053253435,0.005812735,0.018307898,-0.09414194,-0.06874146,0.046832137,0.022814024,0.026028395,-0.112582065,-0.05259088,0.012824382,-0.018138494,0.07009903,0.015097638,0.038690526,0.02103249,0.046909235,0.014630307,-0.09338062,-0.044225715,-0.001820517,-0.007979378,-0.07416092,0.052704297,0.08791365,-0.09004777,-0.05668894,0.015848191,0.05860351,0.022828605,0.005241045,0.067688316,0.046102185,0.13630691,-0.03273388,0.051249754,0.078192875,-0.009392397,-0.07137332,-0.045928746,-0.046358626,-0.04024065,-0.021280892,-0.045949902,-0.02875629,-0.060739107,-0.025477942,-0.00774548,-0.013577777,0.004189306,-0.090540975,-0.10786483,-0.073134996,0.0049784877,0.065086834,0.029947605,-0.040307354,0.08164843,0.0196164,-0.022175517,-0.01611767,0.07941457,0.08744285,-0.00053251145,-0.06500532,-0.020028166,-0.04288105,-1.8035928e-33,0.0809238,-0.02443382,-0.02390859,-0.056960046,-0.059981093,0.12201893,-0.018186152,0.11653885,-0.033960134,0.004557597,0.03721836,-0.013035014,0.025492601,0.0042541525,-0.010661348,0.06180675,0.09145366,0.0974228,0.021425901,0.041342955,-0.066513866,-0.01823736,0.04470353,0.012718561,-0.047324426,0.03255366,0.07350739,-0.01948341,-0.03575098,-0.015189124,0.010161529,0.046687666,-0.07028565,-0.107547686,0.01741063,-0.020820804,-0.061692625,-0.14029698,0.061781883,-0.033736486,0.022843298,0.02582486,0.0017062834,0.046041694,0.053873003,0.07640587,-0.047297813,0.06786461,-0.040382087,-0.005803356,0.012951686,-0.010262544,0.027321098,-0.0075028236,0.05149467,-0.059415992,0.029025307,0.025537416,0.022050885,-0.02791916,0.052800704,-0.055730145,-0.0437575,0.017258627,0.058042023,0.06270013,0.010655819,0.0003555908,-0.08286,-0.06819564,0.024660438,-0.008624479,-0.02170531,0.05812946,-0.053176176,0.055118788,0.02745313,-0.091779985,0.11933531,5.7364316e-05,0.03345466,0.0031076092,0.03645475,-0.06668634,0.02379681,-0.12468842,0.013645397,0.010673764,-0.026163328,0.0018491739,0.026158648,0.022046346,-0.06471749,-0.075562395,0.113641344,-1.8998664e-08,0.1475503,-0.024478454,0.04094887,-0.013424364,-0.018970974,-0.048324276,0.048801266,-0.04369487,0.03961114,0.026461255,-0.03683796,-0.05930373,0.023570377,0.0050884425,-0.0039644847,0.005920002,-0.01260841,0.024540436,-0.024143022,-0.008769429,-0.09834787,-0.015752755,-0.022893833,-0.022729134,0.0031804636,-0.0652359,0.116126254,-0.051843338,0.051599,-0.0662561,-0.068041965,-0.016928226,-0.0453653,-0.07490357,-0.05771551,0.027639767,-0.0756865,-0.0070041553,-0.0021537964,-0.046499595,-0.037088066,-0.01036584,-0.033746194,0.008386588,-0.012468732,0.0056879004,0.008175274,0.0050761593,-0.051008593,-0.05806573,0.0048845178,-0.023693325,0.056563355,-0.053227387,-0.11073429,-0.033656277,0.046273973,-0.042235192,-0.08823553,-0.011932412,-0.04930646,-0.023611741,0.104769506,0.06739427 +5.5.1.30,Isolated from the bacterium Streptomyces clavuligerus.,384,0.99999994,-0.038562708,0.015152628,-0.17345053,-0.005825991,-0.0034086157,0.05645354,-0.012960928,0.050054695,0.08277763,-0.08170336,0.025506573,-0.05369447,0.050464764,0.036627218,-0.072051734,-0.035949104,0.021544617,-0.025744727,0.09264257,0.008468012,0.032869905,0.10423039,0.015695212,-0.03926806,0.03380736,0.06326376,0.011335481,-0.009353359,-0.015882898,-0.025748404,0.0313212,-0.054931138,0.040002882,-0.03526942,0.12881592,0.056586646,-0.029491555,-0.012851337,0.16889717,0.06556503,-0.045484796,0.050727487,0.01929078,0.0258306,-0.054552402,0.08528584,-0.004547351,0.0848769,0.05979345,-0.05654297,0.015968155,-0.0666802,-0.069902904,0.027682854,0.055494733,-0.0048342203,0.016331391,-0.03231418,0.0044174874,-0.014119899,0.039033905,-0.012449779,0.081170216,0.0126387235,-0.10130026,-0.030511856,-0.021256186,-0.00045114104,0.09204655,-0.018099856,0.0071749478,0.015752876,-0.022292554,0.076789364,-0.035132073,0.017480409,0.012274289,-0.01778657,-0.030876063,0.011639608,0.017789662,-0.011440462,0.0065384656,0.07360489,-0.0030214854,-0.06440124,0.05546235,0.032240294,0.038605582,0.0028425213,0.033543404,0.034090575,-0.005423642,-0.052664965,-0.07153836,-0.012289202,-0.071229376,0.02159404,0.0126320785,-0.00791994,-0.04724483,-0.021564798,0.124642,-0.021460256,-0.020654341,0.011606178,-0.05082767,0.018616965,0.06719023,-0.05345403,0.0020525604,0.043715574,-0.04636178,-0.0609321,0.0906715,-0.021019574,0.17371634,-0.041111898,-0.025892738,-0.006246615,-0.041488905,0.010843748,0.07606127,-0.0042997086,-0.018493718,0.075352855,-0.06463888,1.4211723e-33,-0.019235745,-0.05248563,0.08314244,-0.06373028,0.01891112,0.006914791,0.011820566,-0.022619214,-0.016986348,-0.023898255,-0.040372834,-0.10806821,-0.0076777996,0.0035382733,0.037307803,0.022878772,0.004726985,0.014274699,0.0284465,-0.054796077,-0.0024990225,0.052629784,0.022509431,-0.017925737,0.021243766,-0.0063865674,0.0036583163,-0.019271744,0.14795874,-0.05019956,0.08009319,-0.039842077,-0.08319062,-0.052947037,0.029114924,0.019207088,-0.060608618,-0.026651543,0.028347611,0.028449034,-0.00084557064,-0.02661912,0.04245192,-0.0067421435,0.072111584,-0.029445032,-0.06825291,0.061307263,0.034623478,-0.010084426,-0.0209567,-0.03583148,0.042288177,-0.01929991,-0.07852073,0.00595979,0.044095505,0.05314842,0.036927056,0.04164867,0.05791084,0.08111208,0.0111326985,0.011703544,0.091995366,-0.005435742,-0.04935515,-0.024886662,-0.05252977,-0.0030963705,-0.023474967,-0.02427679,-0.011475954,-0.08130321,0.0033325106,-0.042584557,-0.072270736,-0.05386225,-0.0009809801,-0.018636877,-0.07195188,-0.008219254,0.05877885,-0.04833214,-0.08683974,0.071099035,-0.0727751,-0.0125626195,0.02943768,0.089426614,-0.07274839,-0.003735462,-0.14117993,0.041366395,-0.042838585,-2.2435759e-33,0.09171281,-0.06290611,0.043144412,0.008982995,-0.043624822,0.12722638,-0.11264582,0.059868384,-0.091117315,-0.017002765,-0.0032808525,0.007512646,0.024468193,-0.047928028,0.02549123,0.051197443,0.012684529,0.13022274,-0.05456722,0.03552199,-0.005015092,0.0248923,0.018862763,-0.034712017,-0.008231898,-0.015853247,0.025128447,0.009376211,-0.008277562,0.0050347513,0.018258706,-0.0054193395,-0.064972594,-0.058373418,-0.070624895,0.00443243,-0.044762,-0.05474942,0.0883862,0.0033046152,0.006980928,0.03377082,0.0058725993,0.07039531,0.035148937,0.019632764,0.0023049628,0.038606368,-0.0075768093,0.047424484,-0.04901414,-0.03416306,-0.00028831288,-0.012304912,-0.013466345,-0.02291389,-0.06532088,0.027454088,0.021358475,-0.07119924,0.009359479,-0.03846475,-0.0471113,-0.010808366,0.13420892,0.07633711,-0.021747336,0.0672498,0.027177114,-0.08491354,-0.008476176,-0.016217366,-0.066712,0.03855457,0.043742288,0.048281994,-0.069935486,-0.024109978,0.022289446,0.03839599,0.02519088,-0.07635306,0.06117493,-0.04133721,0.025860416,-0.058983624,0.045132663,-0.054091487,0.014372716,0.01439213,-0.026372224,0.029637253,-0.009370452,0.017521698,-0.008608904,-1.9126826e-08,0.07252732,-0.03165196,0.043647315,0.021216037,0.008109738,-0.083642855,-0.041821435,-0.051039893,-0.0078593725,0.05620588,-0.08473676,-0.091665216,-0.01668611,0.013242367,-0.010432845,0.01965468,-0.028262626,-0.038981434,0.02894918,0.014440702,-0.07918301,-0.030688785,-0.0008864833,0.09552079,0.033328503,-0.044428606,0.054013107,0.004260788,0.053670894,0.03887172,0.024343334,0.0038318736,-0.053182296,-0.020024655,0.02358997,-0.00019246161,-0.09281975,-0.027875232,0.0074768434,0.026930613,0.015163851,-0.022634536,-0.013928278,0.007048418,-0.09970554,0.034652658,-0.031249769,-0.0072475607,-0.11331804,-0.06681414,0.08105209,-0.005448318,0.038830765,0.055657152,-0.10268328,0.034819882,0.03996693,-0.08961808,-0.0588424,-0.017510846,-0.050142452,-0.02511712,0.13355592,0.05373507 +6.1.3.1,"The enzyme, found in certain bacterial species, participates in a pathway for the production of olefins. It forms a beta-lactone. The alkyl group at C2 of the substrate ends up as the 3-alkyl group of the product.",384,1.0,-0.034829192,-0.097312674,-0.050477784,0.044592537,0.10695737,0.05407299,-0.06758816,0.035955533,0.0702944,-0.0068351203,0.044613607,-0.051165175,-0.09546431,-0.01114394,-0.05039364,0.04803139,-0.1305247,-0.016285941,-0.02125204,-0.006829456,0.09582299,0.042159528,0.041799128,0.024833407,0.005862339,-0.008957766,0.057213917,-0.023679096,0.066337675,-0.06286222,0.013523135,-0.0227277,0.03993099,-0.0073317415,0.018403409,0.008888552,0.035310656,-0.13678853,0.021502348,0.0599658,0.0790914,-0.033113413,-0.022711948,-0.0155575145,0.016521871,-0.022118328,-0.0019913658,0.03860122,0.045707066,-0.033659227,-0.0454615,-0.07204176,-0.052154366,0.060909573,0.02464052,0.016606698,-0.018560167,-0.060695555,-0.021395616,0.011491494,0.07931408,0.019646406,-0.027793644,0.0047693257,-0.005982,-0.013607411,0.04701853,-0.0639592,-0.026242081,0.00771982,-0.09069153,-0.070582055,-0.029296407,0.100027554,0.054133404,0.007313606,0.042618558,-0.07470906,0.013606633,0.012506123,-0.0021412782,-0.011945893,-0.02194464,0.092543766,0.018793125,-0.046281394,0.035088662,0.030904084,0.059589516,0.03722609,-0.04691993,-0.0214144,-0.06638289,-0.067317665,-0.027501924,0.02049027,0.056861464,0.017374745,0.072796404,-0.0018628255,-0.0513963,-0.0056614,-0.012977836,-0.104306854,-0.11754887,0.04063887,0.036292735,0.038319334,0.0010652452,0.0017037428,0.017288322,-0.030527199,0.01898427,0.019276623,-0.121906534,0.03900635,-0.006700717,-0.14453425,-0.020083684,0.014064692,-0.034766566,0.010632479,0.0711513,0.13151571,-0.057526276,0.034641497,-0.10431235,-3.5233775e-33,0.015619841,-0.0042979,0.001546946,-0.075625576,0.07019406,0.013664148,-0.072738834,-0.020254925,-0.051713355,-0.022914018,-0.048567437,-0.02361076,0.009138888,0.03627994,0.05437101,-0.053395074,0.03495384,0.05359696,0.0075324,-0.025685173,-0.023004858,0.042226143,-0.030723386,-0.021013362,0.052145258,0.011408627,-0.011887997,0.0067949723,0.022660743,0.0147628,-0.0077523505,-0.07223831,-0.092490464,0.018136721,0.07085856,0.031204239,-0.01037534,-0.074130595,0.043450292,0.06129605,0.048100647,0.007874817,0.018849215,0.039416257,0.008311011,0.0002380493,-0.03957844,0.07504573,0.07591713,0.013491281,0.026741596,-0.04888316,0.03299559,-0.025290297,-0.040516462,0.06650149,-0.1432001,-0.014240117,0.014116635,-0.009273956,-0.06435488,0.013226282,-0.046570256,0.054344784,-0.032171104,0.02336145,-0.02538495,-0.014874918,-0.008529222,0.009878213,-0.04942555,-0.059327964,0.057901245,0.046378706,0.007023482,0.03448683,-0.09267127,0.021886962,0.01876965,0.017589713,-0.02086822,-0.074114725,-0.042426787,-0.036219705,-0.07978686,0.013041439,-0.03441353,-0.011566132,0.004083193,0.0026501568,0.034559693,-0.03528053,-0.02662649,0.056227524,-0.0015600388,-3.7823333e-34,0.07223447,-0.11794339,0.032670423,-0.1167295,-0.023940407,0.037024625,-0.012650649,-0.057229366,0.0371005,0.0042603747,0.09905959,3.0911044e-05,-0.022746343,-0.0834474,-0.04773384,-0.029289814,0.033561353,0.09040197,-0.001815201,-0.048424926,0.017553972,0.025168164,0.0359588,0.027683366,0.028383302,0.024952667,-0.01598882,0.09478473,-0.01238269,0.08190946,0.0124015445,-0.0054905373,0.006433089,-0.031103091,-0.0032884006,0.07692213,0.005833799,-8.0118225e-05,0.032869704,0.047274943,0.032645054,0.013025716,0.020983143,-0.007099874,0.078671806,0.096283905,-0.014466095,0.018868282,-0.0033464467,-0.1031761,0.04627944,-0.014811522,0.07707765,0.0073513472,-0.040810034,0.116418235,-0.01293001,0.016760027,0.010092273,-0.05599689,0.0017840302,-0.009901516,0.06551008,-0.029104235,0.020676667,-0.021462118,-0.04803389,-0.027595937,0.046247277,-0.041567408,0.029579628,0.03931277,-0.042052407,0.0847064,-0.07186246,0.045872416,-0.08192,-0.11558284,-0.07280015,-0.0381821,-0.018048918,-0.008773751,0.0065653226,-0.03970322,-0.06736156,-0.04429481,0.048433114,0.08154899,0.0016723464,0.017439416,-0.07972593,-0.0012125184,-0.09997293,0.10297793,0.059831504,-3.2955057e-08,0.0019873981,0.00063992775,0.038623277,-0.002985532,-0.03401772,-0.006037561,0.03393985,0.030379906,0.09183185,-0.04490352,-0.07255744,0.07111267,-0.005008154,-0.01262901,0.07854438,-0.0039501856,-0.048419524,-0.04222836,-0.009455383,-0.07267967,-0.01446763,-0.045468412,0.02169122,0.055444047,-0.05242001,-0.051550847,0.020245811,0.13204826,-0.031730574,0.005305507,0.058873117,0.08142024,-0.04318893,0.049381707,-0.05273131,0.024123682,-0.061751314,-0.06351448,-0.0057590697,0.071706064,0.018999161,0.03478798,-0.05509505,-0.008137846,0.01745834,0.029392961,0.023370648,0.05944314,0.034455646,-0.04993126,0.081749745,-0.0090069445,-0.085994065,0.03552282,-0.07946295,-0.07730545,-0.09363241,-0.023024485,-0.0056120194,-0.051513728,0.0064728637,0.013573981,0.18427761,0.008687872 +6.2.1.50,"This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase.",384,0.99999994,-0.045354474,-0.03279164,-0.0927889,-0.013593988,0.0057822624,0.0010350242,0.018095838,0.039127406,0.040365342,-0.0010142368,0.0075524882,-0.11398907,-0.014202238,-0.008727936,-0.04457891,0.07838171,-0.048338704,0.023435656,-0.053147938,-0.08379338,0.035936255,0.053918846,0.013851226,-0.013790724,0.034812175,-0.0031078674,0.07576942,0.019584278,-0.019701041,-0.084979296,0.0032068247,-0.10341739,0.028880524,-0.014964731,0.06966009,0.12021973,-0.02572338,-0.1559684,0.09828216,0.047434498,0.08785938,-0.046677213,-0.025590414,0.013126819,-0.027105032,0.035302415,-0.050578676,0.05994723,0.008990735,-0.038957432,-0.06101862,-0.008445799,-0.030363286,0.022171384,0.00047586515,0.08096679,0.014745054,-0.0376034,-0.0012310644,0.042499386,0.047939822,-0.012923437,0.002132286,0.054787584,-0.050607637,-0.07715059,0.0073910635,-0.041751917,0.038768314,-0.04202059,-0.10018834,-0.042834893,0.010101682,0.04805367,0.054141786,-0.05908953,0.00015139034,-0.02917264,0.027654452,-0.0068125473,-0.012269538,-0.04319288,-0.031226013,-0.03896291,0.031519018,-0.08580927,0.12083993,-0.014785261,0.005166969,0.098820016,0.040244434,-0.110151775,0.041366406,-0.052365057,-0.058551293,-0.0052024988,0.13644877,0.0016810123,0.023697704,-0.03145154,0.0049642,0.0043459227,-0.025040017,-0.027878597,-0.057066623,-0.005419343,-0.031652387,0.08853918,0.02320146,0.032377414,-0.03884565,0.00715259,-0.014778169,-0.008824856,0.015066919,0.13847902,0.0077915452,-0.06305213,-0.024167662,0.01975507,-0.012282167,-0.06782572,-0.01605713,0.062094774,-0.12444225,0.016549641,-0.11564051,8.409472e-34,0.045752984,0.017845184,0.0026270247,0.012120844,0.019935252,-0.012570681,-0.14183873,0.005454545,-0.028414892,-0.15273973,-0.025333926,-0.051733866,0.012712148,0.05349718,-0.093031116,0.014756478,-0.09978515,0.033138912,0.084737144,0.08807866,-0.0004702198,-0.024942217,-0.036759626,0.0312525,-0.013954259,0.063053355,-0.069264464,0.0030220656,0.030741615,0.03478574,0.009421838,-0.051379483,-0.06650033,-0.013735865,0.0038526468,-0.027706174,-0.0077396315,-0.114091374,0.051658493,0.034732815,-0.015161895,-0.049113728,0.025858713,-0.024405496,0.048495848,-0.03597587,-0.006989598,0.058824286,0.0020563502,0.061645813,0.024802133,-0.08844126,0.122502476,-0.038612794,-0.018925058,-0.04018351,-0.07390481,-0.054416094,-0.0063159205,0.02506398,0.032778855,0.09726527,-0.012118345,0.06685319,-0.04270858,-0.028129786,-0.027816098,0.0059833066,0.010163463,0.06616266,-0.038318653,0.005806841,0.053934675,0.008450858,0.06655932,-0.017578539,-0.11163252,-0.005056738,-0.04731005,0.009443953,0.037284125,0.028757725,0.010864688,-0.031659354,0.018908435,-0.028806334,-0.04095741,-0.036373276,-0.019248687,0.043336958,0.033173863,-0.07965552,-0.022060487,0.07782285,0.01348607,-3.591151e-33,0.11785304,-0.11981541,0.036513917,-0.06836436,-0.03914871,-0.018998256,0.060476463,0.054505404,0.024096796,0.022935696,0.06668845,0.022610962,0.02192769,-0.075204454,0.018947903,-0.042433485,-0.005906343,0.031273544,-0.027013374,-0.02336992,0.03647259,0.016935438,0.039851397,0.026890682,0.025629526,-0.014691685,-0.0751418,0.07098101,0.043870702,0.048165824,-0.031706955,-0.015947208,-0.037574716,-0.020070424,-0.016304431,0.01638367,-0.06891592,-0.0008798362,0.044986192,0.022001406,0.051873755,0.051065408,-0.03548006,0.025397923,-0.0048208702,0.09174041,-0.03699573,0.03752496,0.020199392,-0.106429726,-0.03447889,0.045640606,0.0167428,0.037574492,0.0013712171,0.1095355,0.02773102,0.01860853,0.029259354,-0.040559612,-0.09034639,-0.036527373,0.05018026,-0.013311141,0.031578086,0.049036123,-0.0045983153,0.10603443,0.06788164,-0.004663113,0.059210014,0.006366722,-0.032087564,0.0033778558,-0.04085645,-0.06180384,-0.04433558,0.0018257425,-0.018060965,-0.008565362,0.021807367,-0.023487788,0.018370902,-0.116284974,-0.011730662,-0.048422247,0.05087026,0.110684894,-0.044437665,0.025558487,0.025262436,0.09672686,-0.079150155,0.0018695988,0.037647184,-3.5779042e-08,0.012032502,-0.07171016,0.076052144,-0.021742495,0.074559055,0.04812996,-0.04172465,-0.0054852962,0.044625506,-0.0058565103,-0.02620466,0.040924914,0.06564943,-0.00069118035,0.052234136,0.038428076,-0.03944697,-0.023998296,0.036249675,-0.041402053,-0.08051193,-0.03667318,-0.024911566,0.065765955,0.022225909,-0.007169647,0.057147894,0.06431264,0.0057098563,-0.0109704435,0.017579518,0.017878424,-0.058022484,0.021758465,-0.08106962,0.009943925,-0.08312427,-0.082547754,-0.028923308,-0.024242323,0.0459441,0.008356634,-0.043514725,0.052282933,0.03515692,0.08147011,-0.006962523,-0.010201869,0.020125259,0.021531567,0.005008815,-0.034500707,-0.00013856967,-0.013273236,-0.046266444,0.008568544,-0.041321546,-0.036808353,-0.027577499,-0.017485429,0.0068412223,0.06544242,0.15410514,-0.047216404 +1.2.99.10,The enzyme has been described from the bacteria Methylomonas sp. 16a and Bacillus indicus.,384,1.0,-0.040046863,0.019952131,-0.10438873,-0.063270025,0.020453125,-0.01185912,-0.1123689,0.02797927,-0.011249824,-0.021654706,0.0902641,-0.088377,-0.0052464604,0.07365724,-0.0277938,0.134045,-0.043584716,-0.046544325,0.028568063,0.0265429,0.103061326,0.07686944,-0.10840688,0.022966834,0.016829077,0.023834439,0.07006942,-0.05541853,-0.03491484,0.0050501577,-0.040215235,0.007853772,0.091621645,-0.062105816,0.09574433,0.04424841,-0.031290274,-0.01924033,0.11719192,-0.00019702301,0.021238727,0.044661224,0.011603269,-0.05234113,-0.0747921,0.06185689,0.055154767,0.008082748,0.042353645,-0.041072793,-0.080109425,-0.035263855,0.042940967,0.022727666,0.017546624,-0.063045755,-0.05760332,-0.06617949,-0.022011293,0.038046196,0.02702191,-0.04842003,0.0087456275,0.06167589,-0.01688797,-0.054008067,0.06824432,-0.07167363,-0.05170271,-0.07911608,-0.06348913,-0.0673588,-0.002811099,0.052880947,-0.0059937644,-0.005736546,0.053758044,-0.0048555937,0.071727455,-0.02841311,-0.022472711,0.002553788,0.019102924,0.04281634,0.021244932,0.031967267,0.041800205,0.052234273,0.017032301,0.047817755,0.0059616584,0.01785709,-0.050652646,-0.06384666,-0.04365966,0.027777983,-0.026171196,0.0019260981,0.06250727,-0.03569207,-5.467856e-05,0.036690935,-0.08412495,-0.09539343,-0.06763044,-0.026103763,0.06758813,0.054016393,0.04114984,0.080080435,0.03685118,0.08915396,0.015232444,-0.034606114,-0.008910243,0.0233183,0.06681975,-0.024888596,-0.055809382,0.0073805135,-0.029262323,-0.056124035,0.037742533,0.032416172,-0.03419378,-0.006571164,-0.14088704,-9.979294e-34,0.039877515,0.0032755092,0.013562197,-0.080846325,0.061456665,-0.05238297,0.009069873,0.02371087,-0.013882857,-0.07259032,-0.12085946,-0.12886631,-0.0045987233,-0.009146493,-0.03598856,0.023061752,0.022767477,-0.022084195,0.018059094,-0.03491679,0.011174814,0.056597564,0.003931611,-0.028585033,0.03880382,0.056098554,0.04410308,-0.011267014,0.0468625,-0.039017502,0.033521768,-0.08711201,-0.1248854,-0.043225836,0.072786406,0.013589749,-0.011011347,0.01908302,-0.013591345,0.036739293,0.056413766,0.036940955,0.015255241,-0.0049969843,0.024002958,0.006906356,-0.101912156,0.079252444,0.12562698,0.02339806,0.024850251,0.014443408,0.03098893,-0.0945936,-0.07439522,0.0077049676,-0.0088393865,-0.025544595,-0.039930075,0.036969487,-0.038518112,0.045935385,-0.031451836,0.054454125,0.009812201,-0.040637027,-0.07892854,-0.04900767,0.00427718,0.018347757,-0.05929059,-0.023834802,0.056405026,-0.062656835,-0.06521539,-0.052221198,-0.051222205,-0.10501667,0.027764043,0.03136255,0.017045958,0.0037265227,0.039208215,-0.077218235,-0.10085485,-0.0015563293,-0.0065759066,-0.029995436,0.037694253,0.011998914,0.056554608,-0.10415471,-0.04166786,0.042861596,-0.034890924,-1.8559836e-33,0.09275235,-0.06595508,0.10624005,-0.09497081,-0.009774446,0.058765464,0.00226828,0.061061855,-0.00083723915,-0.002857867,0.061195973,0.04611733,0.015439062,0.033666696,0.045656472,0.07429515,0.030193202,0.08022483,-0.009028997,-0.05237894,-0.026306355,0.10380745,-0.0052022873,0.0088049555,0.020464173,0.00035453186,0.051890135,0.11006825,0.014211074,-0.013401225,0.00978683,-0.02450259,-0.03707908,-0.046019465,-0.024744695,0.040719565,-0.044664554,-0.06881994,0.06473801,0.032396413,-0.020714896,0.02748316,-0.049588975,0.081346735,-0.03237504,0.043844983,-0.04642225,-0.013586342,-0.019414753,-0.03503478,0.007698041,0.006358313,0.051250003,-0.0098622795,0.013473557,-0.008468707,-0.06749494,0.052667573,-0.021524165,-0.09339301,0.0037888887,-0.08216504,-0.017990977,0.031420037,0.018724578,0.124986604,-0.028211713,-0.044977926,-0.024616856,-0.02731644,-0.004568577,0.03219184,-0.10312057,0.03594787,-0.058480535,-0.03523548,-0.060210202,-0.06745453,1.5287738e-05,-0.004700433,0.036153268,0.016331887,-0.023522783,-0.04799872,-0.0037055125,-0.02183795,0.04605616,0.06307912,-0.0363174,0.011713682,-0.03248724,-0.0012675954,-0.030960977,0.07276706,0.05845352,-2.5348088e-08,0.038574006,-0.11498379,0.03400169,-0.04684828,-0.036524404,0.06014167,-0.022455897,-0.021964412,0.0721654,-0.043087356,0.008447955,0.030878754,-0.023608508,0.059403274,0.06224185,-0.02409631,-0.022060087,0.00081293395,0.016160578,-0.015667582,-0.042758856,0.05427384,-0.07035593,0.030757716,0.025626019,-0.011144025,-0.0052822875,0.10160112,-0.019337302,0.0008351005,-0.019147176,0.048956566,0.04391116,-0.07284184,-0.081213854,0.03911746,-0.045284774,0.00038885165,-0.0015263192,0.055988397,0.10388051,-0.004579072,-0.090248615,0.02181729,-0.010525013,0.0017320485,-0.039004743,0.07442903,-0.009570928,-0.023868162,0.02315755,0.028134858,0.03044118,-0.0022452534,-0.08204099,-0.010682802,-0.04639977,-0.07244115,-0.046550352,0.002060864,0.068799034,0.00996414,0.13680413,-0.025170965 +1.3.1.113,"The enzyme, characterized from the bacteria Streptomyces griseus and Streptomyces coelicolor, is involved in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.",384,1.0,-0.077385694,-0.029288474,-0.15372524,-0.04228273,-0.022248814,0.06582456,-0.05402394,0.035493143,0.025672711,-0.049839206,0.008824229,-0.061570168,0.007299252,0.057172082,-0.06886616,-0.04005457,-0.052844584,-0.021652061,0.052143894,-0.12322756,0.07962305,0.04697571,-0.0043518106,-0.010815406,0.08154334,-0.021999486,-0.0030061794,-0.036405776,-0.00037965816,-0.03989781,0.016565077,-0.08722022,-0.003911201,-0.024653781,0.06321073,0.089500725,-0.03206051,-0.044169933,0.107296556,0.00835634,-0.029250804,-0.018565318,-0.042416424,0.044929728,-0.07249684,0.014702847,0.059469964,0.031494442,-0.02400285,-0.095619336,-0.05452111,-0.041337863,-0.08756454,0.010535643,0.06556965,0.11181625,0.030354524,-0.049760442,-0.013949648,-0.08200561,0.021427084,-0.06841504,0.029789498,-0.023632692,-0.0528305,-0.006249303,0.036101196,-0.08079003,0.02188732,-0.050725713,-0.07717781,-0.019141793,-0.0655499,0.08544691,-0.043433506,0.03160211,-0.05976237,0.021686092,0.012404053,-0.042262446,0.048542477,-0.0014055317,0.027694795,0.1149798,0.0601559,-0.057736862,0.04405289,0.0153383035,0.13036092,0.070110865,0.02508152,-0.044496216,0.03472659,-0.029556554,-0.06707803,0.022999126,-0.048258968,-0.028063023,0.051593382,-0.04991042,0.003577692,-0.0038161043,0.024729032,0.050351515,-0.006837981,0.002421342,-0.04038824,0.05054343,0.049994193,0.0020269079,0.030113356,0.042154405,0.01514933,0.009901975,0.01275033,0.048363667,0.13608803,-0.0354476,-0.07694382,0.03846281,0.004888597,0.04877159,-0.0033550593,0.031500615,0.011615914,0.026716728,-0.114445694,5.0441767e-33,0.00071972905,0.04627713,-0.00013489454,-0.053736694,0.021152763,0.009891447,-0.12053981,-0.006991937,-0.0027867714,-0.023355719,-0.063745655,-0.0891185,-0.012821083,0.033998664,0.026076617,-0.012401539,0.0068085273,0.08759954,0.0476557,-0.032746553,-0.035484083,0.06403514,-0.015889259,-0.056379955,0.037376523,0.062067367,-0.040446486,0.06582298,0.0627774,-0.039272513,0.058389843,-0.14278126,-0.087534145,0.042356495,0.06609012,-0.047495376,-0.025535366,-0.048074275,0.04828696,0.0613036,-0.032457706,0.041189793,-0.06302998,-0.016735194,0.037337765,-0.04523715,-0.0015502505,0.08031655,0.02566257,0.026807021,0.021029336,-0.056969956,0.104875736,-0.011698667,-0.010606993,0.08696295,-0.0038713939,0.006761365,0.04132372,0.002104013,0.016866527,-0.0077406648,0.033439606,0.056876987,0.054898843,-0.026372066,-0.011374375,-0.03337983,-0.010711518,0.07890091,-0.095381685,-0.02247328,0.022013286,-0.021004962,0.01201308,-0.05236553,-0.08535415,-0.0222106,0.027803348,-0.01640226,-0.09263268,-0.005637183,0.0067809597,-0.05044218,-0.025126342,0.059843335,-0.03462523,-0.087162934,0.035180137,0.06755767,-0.024053331,-0.06615385,-0.066505834,0.064522736,0.047875155,-5.4149588e-33,0.0638608,-0.085182875,0.019468643,-0.06349614,-0.060226142,0.091712974,-0.03112625,-0.048844755,-0.0046434947,-0.052647967,0.043508276,0.040546354,-0.02391319,-0.038469583,-0.009915025,-0.016040552,0.035147663,0.13574022,-0.016760118,0.00058010675,0.031768702,0.06685223,-0.028691262,-0.033853173,0.0047110245,0.011875618,-0.010927866,0.06390739,0.0277336,0.042926848,0.023668509,-0.014032969,-0.04385387,-0.08172792,-0.009250276,0.045597002,-0.029958222,0.054926362,0.066798,-0.013530842,0.04785013,0.08288233,0.050574217,0.05806863,0.00914358,0.044320416,-0.05025395,0.013020038,-9.55586e-05,-0.03857738,-0.032288216,-0.034406323,-0.032507483,0.03179352,-0.018239534,-0.027733872,0.025679516,-0.020614602,-0.020573998,-0.021756576,-0.023556752,-0.08364605,0.022725845,-0.00990303,0.06470982,0.05470128,-0.046978675,0.027576271,0.08539603,0.03271623,0.044163465,-0.053835742,-0.03996491,0.05354773,-0.0012832698,-0.00495417,-0.09908782,0.009120293,0.04004391,-0.030976724,-0.028429622,0.017433742,-0.017143736,-0.07517451,-0.054299142,-0.09186,0.0070743267,0.10679465,0.07659522,0.06876018,-0.030706136,-0.004468829,0.019838931,0.013904297,0.037679475,-3.691341e-08,0.024328183,-0.024798887,0.047656342,0.013590429,0.013127303,-0.044875413,0.017086491,-0.0358461,0.06032715,-0.021639587,-0.009839208,0.00089766487,0.070711076,0.006369568,0.019488689,0.033620987,-0.01988133,0.028018767,-0.002054223,0.0023275446,-0.07593973,0.0028101685,-0.06641039,0.057193924,0.061679017,-0.08907369,0.050456166,0.05493853,-0.012332831,0.053283196,0.040716596,0.049260672,0.008110337,-0.031293303,-0.064853296,-0.0071650716,-0.028786292,-0.014755086,0.0653692,-2.4206942e-05,-0.017771605,-0.05266931,-0.06412582,0.0031817218,-0.041426133,0.10242067,-0.039008293,-0.00458228,-0.05403506,0.005383792,0.05875111,-0.015281441,0.046308566,-0.008580637,-0.09916144,0.040695276,0.036762632,-0.03001644,-0.048730373,-0.041431442,0.016931344,0.031447824,0.18946221,-0.1255164 +1.3.8.14,"Contains FAD. The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It is believed to catalyse the formation of a Delta2-pyrrolin-2-carbonyl-[peptidyl-carrier protein] intermediate, followed by a two-electron oxidation to 1H-pyrrol-2-carbonyl-[peptidyl-carrier protein].",384,1.0,-0.07736695,-0.019563574,-0.08907974,-0.055167243,0.094548106,0.054807715,-0.015003395,0.07577574,0.07017115,-0.004497982,0.016136117,-0.004006711,-0.07769674,0.020164212,0.04304229,-0.024402153,-0.12163724,0.012074251,0.025912926,-0.1365128,0.042962257,-0.025253177,0.03529192,0.021919042,0.0042511947,0.018244553,0.04695711,0.04619036,0.026999196,-0.048409842,0.0247569,-0.002811392,-0.044510204,-0.022360545,0.07696486,0.032262392,-0.04364456,-0.019156694,0.058385514,-0.011724424,0.08284294,-0.016933143,-0.0093917865,0.0006968116,-0.035514858,0.0025803188,0.020486293,0.06307158,0.0022928084,-0.040260974,-0.023594817,0.00880576,-0.032144662,-0.014498762,0.030632943,0.07483549,0.04621659,-0.035058133,-0.02854371,-0.036124874,0.02002016,-0.0046672653,-0.02463235,-0.0140069695,-0.06551858,-0.077832595,0.006309251,-0.059307855,0.06188351,-0.012450009,-0.032135766,-0.06385825,0.022408495,0.053461947,0.035145245,-0.0033133377,-0.05551708,-0.0511474,-0.018811177,-0.055295903,0.05638871,-0.02980497,0.08460317,0.07130755,0.043311935,-0.038866997,0.0142113445,0.006941647,-0.0005134416,0.025374586,0.05239327,-0.027055657,0.008953189,-0.0028494624,-0.11526589,0.09821707,0.015046912,-0.010685456,-0.008336368,-0.070294224,-0.0032348894,0.030952105,-0.03017554,-0.08769938,-0.03618316,0.012495134,-0.021847362,0.07097709,0.0399218,-0.019183047,-0.06128288,0.020071754,-0.01532288,-0.0151742315,-0.043617327,0.10224791,0.056149103,-0.029829958,-0.03831192,-0.01342749,0.017165016,-0.00087716215,0.050065547,0.125239,-0.062098347,-0.05987039,-0.09312712,2.694951e-33,0.029518243,0.052084256,-0.045586534,0.06442239,-0.030777909,-0.008429637,-0.10579076,-0.06787397,-0.023509052,-0.02520262,-0.06291617,-0.1099714,-0.019210182,0.049372226,-0.021995084,-0.063092284,-0.03924528,0.02711646,0.07069538,-0.04887341,0.060337987,0.12927464,-0.0112291435,0.05209821,0.09728907,0.061758995,-0.0043279226,0.085358635,0.05806989,-0.0011865954,0.016559392,-0.095149145,-0.09936868,-0.005740694,0.025363408,-0.032479387,-0.08897579,-0.027986431,0.0025802923,0.06526996,-0.0046716724,-0.051112566,-0.03682934,-0.027733447,-0.0014010307,-0.08624264,-0.047580082,0.07972399,0.06446187,0.066138275,0.02392433,-0.026107144,0.09918181,0.026376931,-0.09902129,-0.0063029574,-0.0324039,-0.08378653,0.04999243,0.004257501,0.08519355,0.04734091,-0.052714426,0.0011267638,0.0066011148,0.019225819,0.026716523,-0.048504815,-0.013826836,0.11055858,-0.03230424,0.0015745546,0.064702734,0.025462477,0.10198776,0.0043892283,-0.07839831,-0.011889813,-0.0062071984,0.039166007,-0.027609626,-0.018624203,0.05007809,0.002775632,-0.023257747,-0.04933558,-0.06779436,-0.06275372,-0.0034588845,0.013250195,-0.0039539826,-0.08338989,-0.028725462,0.098186225,0.0044416767,-4.5191487e-33,0.045858037,-0.027081039,0.09724699,-0.10718618,-0.085977696,0.015082945,0.043230206,-0.06153046,0.042672154,0.008016198,-0.011687441,-0.045278475,-0.02959197,-0.040575985,0.00822632,0.0010555651,-0.07890845,0.051047973,0.011412888,0.051332287,-0.03592333,0.006453938,-0.0012872947,0.07868737,0.036076292,0.044067997,0.017239366,0.0049200407,0.04114676,0.03914305,0.009821342,-0.002266404,-0.025797708,-0.032507546,-0.09882012,-0.009219384,-0.06614935,0.060936473,0.0014668969,-0.03172373,0.050185554,0.0226922,0.010558492,0.0021925978,0.0315198,0.0039366595,-0.02449421,0.040866215,-0.016398177,-0.059378345,-0.018441176,0.0768394,0.050383903,-0.002090106,0.07883901,0.029516255,-0.0053882156,0.0137095265,0.064446524,-0.007804855,-0.048237517,-0.0741563,0.012767144,0.045119792,0.03311401,0.03815188,-0.025117908,0.051120616,0.061748087,0.052002475,0.10926942,0.084781766,-0.028562084,0.08411348,-0.051315755,0.02670414,-0.026741039,-0.044086713,0.02397876,-0.008289051,0.013355964,-0.05093929,-0.006321236,-0.070956655,-0.11188183,-0.07452768,0.056315333,0.08561655,0.030666191,-0.007907851,0.012869104,-0.0051486776,0.036618046,0.06841282,0.07791177,-4.770161e-08,0.0037658382,-0.025290156,0.05803342,-0.05704537,-0.00198943,-0.00845227,0.0022140648,-0.048447058,0.03492007,-0.034147624,-0.07752867,0.03499674,0.020388436,-0.028502373,-0.00064196484,0.10485133,-0.048256654,0.028971504,0.021616498,-0.028458964,-0.059301753,0.017785901,-0.12325446,0.024016105,0.012379664,-0.027338477,-0.021233356,0.018675169,-0.015226708,-0.0056006713,0.018922433,-0.00794235,0.0023169948,-0.031717293,0.02446814,0.04354481,-0.043768223,-0.066042684,-0.01045442,-0.026885172,0.010307333,0.009181849,0.015071766,0.010794265,-0.008247862,0.01684923,-0.016130157,-0.030018548,-0.03696951,0.01695488,0.078051604,-0.006854781,-0.030782357,-0.094010495,-0.18614656,0.07944974,-0.052304775,-0.05306772,-0.0216541,-0.104513735,0.016801555,0.017328896,0.17863631,-0.011226309 +1.8.5.8,"Contains FAD. This eukaryotic enzyme, located at the inner mitochondrial membrane, catalyses the first step in the metabolism of sulfide. While both sulfite and glutathione have been shown to act as sulfane sulfur acceptors in vitro, it is thought that the latter acts as the main acceptor in vivo. The electrons are transferred via FAD and quinones to the electron transfer chain. Unlike the bacterial homolog (EC 1.8.5.4, bacterial sulfide:quinone reductase), which repeats the catalytic cycle without releasing the product, producing a polysulfide, the eukaryotic enzyme transfers the persulfide to an acceptor at the end of each catalytic cycle.",384,1.0,-0.08210766,-0.049271114,-0.063112155,-0.035838235,0.011203167,-0.04143428,-0.024822926,0.036456853,0.061732344,-0.012291567,0.06857294,0.02809131,-0.019304158,0.017244251,-0.06673072,0.045111764,-0.083065234,0.013014953,0.01412727,-0.0603877,0.04150584,-0.062131356,-0.057773307,-0.100159094,0.01287817,0.0653809,0.025708165,-0.03598317,-0.09253211,-0.026697798,-0.027450424,-0.07636847,-0.05591939,0.011273455,-0.06553285,0.12699108,-0.020579776,-0.046557773,-0.014037758,-0.06050168,0.0072821137,0.0025072831,-0.027751915,-0.011557698,0.008300517,0.020196358,0.057673126,0.013485521,0.0071147536,-0.08809599,-0.03146913,-0.02379521,-0.016338136,0.12373961,0.02487554,0.056205127,0.0052315583,-0.02110612,0.008225905,-0.02907214,-0.039123602,0.0243534,-0.03108345,-0.047070608,0.019618722,-0.07261724,0.041855007,-0.03764457,0.0047357175,-0.03026154,-0.024543121,-0.010252637,0.0015918477,-0.021671776,0.0011503965,0.038473126,-0.052384313,-0.041793376,0.044148564,0.0009000598,-0.013214918,0.008624213,0.077876665,0.10975408,0.030587511,-0.055514935,0.016881974,0.017424505,-0.018845499,0.03346577,-0.034218296,-0.0170344,-0.027601087,-0.03630129,-0.11004734,0.054268744,0.003404171,0.10152973,0.00046281648,-0.05394396,0.035020072,0.035662483,-0.025695223,-0.08680304,-0.04611028,-0.029549437,0.025636887,0.14142643,0.0054093315,-0.008670544,0.008445957,0.04313673,0.013101071,0.0056804703,-0.03151048,0.13930881,0.07398578,-0.033651,-0.07051659,0.034188382,-0.05030269,0.0569864,0.032254566,0.013077675,0.025413718,-0.03971134,-0.103204735,1.8177106e-33,0.04797556,0.061338622,0.052235976,5.3516324e-05,-0.07518048,-0.03115063,-0.13364953,-0.0096499575,0.03649331,-0.040447216,-0.0709666,-0.06874489,-0.02069025,0.03190158,-0.033508677,0.0032726016,-0.039312657,-0.019866275,0.12615138,-0.06551685,0.0217138,-0.009323271,0.03997744,-0.09155774,0.07573611,0.0051480234,0.034619533,0.029787118,0.005073873,0.0045373146,0.07337864,-0.099424556,-0.008593116,0.04873958,0.028087808,0.022817357,-0.03267107,-0.011932713,-0.012380259,0.00029587361,-0.01933551,0.013292773,0.033458967,-0.008194521,0.065981634,-0.044763133,-0.040684327,0.026861409,0.060939338,0.06299709,0.01902381,-0.0936989,0.09885458,0.0055586556,-0.04694851,-0.0059514213,0.016828692,-0.043048743,0.030573433,0.07121609,0.10169765,0.0890345,-0.053758178,0.020048678,-0.02040136,0.044873077,-0.021825565,-0.024674753,-0.03632832,0.1494958,-0.08895429,-0.08599743,0.01651672,0.025250096,0.0047307946,-0.024382148,-0.021602822,-0.04019961,0.057710413,-0.0029705998,-0.020823414,-0.08078309,-0.032986343,0.019208256,-0.057345647,-0.02996643,-0.021549959,-0.040423013,0.021881506,0.017153502,0.0680256,-0.055072326,-0.054715943,0.03753998,0.010199389,-3.4630346e-33,0.07353719,-0.059242524,0.083044626,-0.12096019,-0.02164462,0.08438605,0.017908953,0.007501524,0.09449804,0.013898628,0.023571406,0.029862843,0.017699031,0.023440182,0.008218965,-0.023235122,0.010298128,-0.0010470306,-0.009488167,-0.030454632,-0.016680233,0.11342186,0.0230169,0.043591116,0.018506758,-0.005709423,0.021566102,0.052178357,0.06680407,0.052466754,0.014571731,-0.014436602,-0.041115798,-0.014727834,-0.0109966295,0.006313042,-0.044294704,0.054806072,0.019928219,0.0014064434,0.009506865,-0.04493293,-0.0007188696,0.07894669,0.016203647,0.0044116317,-0.09529721,0.031064076,0.007064346,-0.10686928,0.03948413,0.023052912,0.018032579,-0.026988996,0.07692994,0.04783753,0.0016708947,-0.034588605,-0.0022430944,-0.053068206,-0.07998119,-0.13573132,0.028592162,-0.07256099,-0.04677231,0.01970479,-0.021842211,0.009147003,-0.011275306,0.026019985,-0.004176146,-0.019789524,-0.05615453,-0.0155345285,-0.04991083,-0.0060997508,-0.047430385,0.03210404,0.046503887,0.037826553,0.0005886714,0.027314952,-0.0017863581,-0.036740225,0.03306211,-0.09735357,0.031690083,0.081336476,-0.013361363,-0.05766908,-0.0035984644,0.040356606,0.007279658,0.0061334535,0.0010880827,-4.067742e-08,-0.06739704,0.008411577,0.12463934,0.041231614,-0.049563225,0.041289665,0.025265815,0.047124933,0.01019092,0.05060845,-0.032653026,0.16747981,0.03955185,-0.06542415,0.018740973,0.08838633,-0.026840324,-0.014081151,8.543712e-05,-0.043078784,-0.03180775,-0.03170357,-0.11475742,0.051170994,0.035403863,-0.035105485,0.07380935,-0.039811727,-0.09903891,-0.038829718,0.063446164,-0.01545127,-0.0079106875,-0.0040094233,-0.04152012,0.05047281,0.011166175,-0.018678235,0.019510629,-0.05446874,0.028035676,0.027675314,-0.08191318,0.041249312,0.018203482,0.07290825,0.012084027,0.015942043,-0.088588715,0.011072249,0.10548357,-0.026393125,0.019968523,-0.07054002,-0.09906533,0.049537785,-0.014289334,-0.08076821,0.0070647732,0.019810323,0.111513056,0.02330721,0.115965635,0.040189646 +1.8.7.3,"HdrABC is an enzyme complex that is found in most methanogens and catalyses the reduction of the CoB-CoM heterodisulfide back to CoB and CoM. HdrA contains a FAD cofactor that acts as the entry point for electrons, which are transferred via HdrC to the HdrB catalytic subunit. One form of the enzyme from Methanosarcina acetivorans (HdrA2B2C2) can also catalyse EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.",384,0.99999994,-0.056290627,-0.0047605317,-0.15395449,-0.025554655,0.0620422,0.027293155,-0.068310276,0.007268744,-0.077293456,-0.04646537,-0.10742444,-0.066070355,-0.01836875,-0.04182963,-0.027584866,0.007062517,-0.06784232,-0.07656131,0.0043319385,-0.01213675,0.029947683,0.013967291,-0.03134002,-0.003718402,-0.06418369,-0.015032761,0.027804598,-0.010265996,-0.0846754,-0.11187537,0.08330218,0.0024934553,0.047056813,-0.011972489,0.041169908,0.026793566,-0.042378422,-0.069323055,0.027297897,-0.03639197,0.031870022,0.057951115,-0.02007024,0.043008704,0.008663883,-0.060165737,0.014824977,0.016045066,-0.009961307,-0.028932065,-0.038458847,-0.03329027,-0.06779737,0.08900269,0.09265364,0.028811686,0.02869474,-0.046687443,0.07591389,-0.017602878,0.035495725,-0.016367208,0.047357187,-0.042263366,0.0072493353,-0.022140477,0.014631762,-0.086899355,0.026274066,-0.054509345,-0.07048486,-0.035013534,-0.104701445,0.03341363,0.038105965,-0.009095965,-0.022044986,-0.017577277,0.042761136,-0.015054293,-0.06388914,0.021662662,0.07247739,0.07137455,0.048806317,-0.004652122,-0.059889935,-0.055619374,0.016497979,-0.02388482,0.07456623,-0.030919714,0.038491238,0.022186834,-0.06977472,0.007858287,0.076572314,0.095156424,0.07926398,-0.01609597,0.021258704,0.012407661,-0.08441449,-0.11806971,-0.06897392,0.0029625052,0.0876718,0.17702682,-0.005294693,-0.0063903197,-0.042161062,0.013629565,0.053165182,-0.0034353882,-0.050733935,0.055771153,0.036722954,-0.08215337,-0.018166877,-0.045288157,0.05974229,-0.02360232,0.14573696,-0.0075002965,0.0073641147,-0.037881378,-0.18183662,7.238058e-33,0.05744116,0.0329778,0.00062097306,-0.031772185,-0.01663727,-0.039615948,-0.02873541,0.02257095,0.015936038,-0.00084281643,-0.066260405,0.044193607,0.06183641,-0.024990562,-0.10434912,-0.05924692,-0.012972244,-0.019259539,-0.040537257,0.018472567,0.019009111,0.10339177,-0.008706545,0.011515084,0.04309209,0.024865732,-0.022483984,0.04772515,0.05604234,0.027476696,0.00053379656,-0.11064517,-0.06963451,0.019598989,0.019303031,0.01181306,-0.07429886,0.0046294113,-0.092090115,0.022977328,0.0061572026,-0.00906268,-0.050818816,0.021128532,0.105740175,-0.011748873,-0.010014892,0.104205616,-0.019632531,0.06584767,-0.05107631,-0.049840614,0.11499711,-0.017584866,-0.05582416,0.0830783,0.011219317,-0.018100727,0.09609394,0.08787306,0.023442915,0.07880829,-0.03474849,0.07041057,-0.032934166,0.037727013,-0.0064796414,0.010653717,0.026291534,0.07729392,0.035370186,0.033727217,0.08466621,0.035663616,0.073241755,-0.052840672,-0.01734955,-0.062115733,0.010834753,-0.020515688,0.029522,-0.013537861,0.06416722,-0.028286079,-0.0256317,-0.04392421,-0.04853857,-0.075460844,-0.104015246,0.047766104,0.032920428,-0.040833615,-0.00016643503,-0.024865001,0.021429582,-6.266835e-33,0.09545303,-0.052201305,0.03041269,-0.0892495,0.020156208,0.04894885,0.062196676,-0.06614097,0.048405536,-0.024335101,0.13047555,-0.0058647883,0.0071947887,-0.05369962,0.037321653,0.055950753,-0.0011618537,0.030588973,-0.05507683,-0.014941051,-0.009064848,0.0038669035,0.0022897038,-0.00865514,0.02720134,0.007649835,0.007384184,0.06944067,0.12060369,0.030226301,-0.05064083,0.011668198,-0.044377077,-0.03243128,-0.12293264,0.03595464,-0.06563435,0.0031249542,-0.028790012,-0.034468032,-0.013890463,0.004428791,-0.009428528,0.04864137,0.06309757,0.1120656,-0.12708612,0.048486322,0.048547063,0.023375118,0.05302054,-0.041946188,-0.0020865295,0.03139989,0.04850944,0.0641981,0.0653786,0.019313624,-0.0012318448,0.005499395,0.0048641246,-0.0275721,0.04261354,0.07980022,0.023455918,-0.00018182333,-0.023141073,0.026061224,0.0032311154,0.054902665,0.065724194,0.02499519,-0.042450372,0.022033023,-0.049009345,0.009405401,-0.080224454,0.012195515,-0.024919145,0.01918644,0.030273236,-0.0069353995,0.06148856,0.0051968605,-0.03193848,-0.08110691,-0.03491455,0.049086295,-0.010705814,0.046245873,-0.0700121,0.020630673,-0.020264301,0.04759223,0.030358566,-4.8433492e-08,0.004148946,-0.050614607,0.03153119,-0.03910858,0.03664435,0.013376437,-0.012138669,-0.01287839,0.023517285,-0.033733584,-0.007632851,0.063734345,0.024046183,-0.036640547,0.011894745,0.020542841,0.029162666,-0.03983912,0.0048178453,0.021246625,0.01702875,-0.0113627575,-0.03906798,0.056320835,0.0145634385,-0.09324869,0.00037779025,-0.003272281,0.011451731,-0.085687995,-0.036474537,0.0528012,0.017274939,-0.02287182,-0.04287321,0.038473144,0.003228079,-0.05597481,-0.034617584,0.057997912,0.010090238,0.0028021757,-0.056849547,-0.021506295,0.055581972,-0.0064763837,-0.022135893,0.052421995,-0.0084892195,-0.07458202,0.01739707,0.00060467434,-0.020360269,-0.06639688,-0.06418318,0.08130721,-0.05495254,-0.007603199,0.015076363,-0.0051283566,0.0809165,0.030949447,0.12014361,0.0038303982 +1.8.98.4,"The enzyme, characterized from the archaeon Methanosarcina acetivorans, catalyses the reduction of CoB-CoM heterodisulfide back to CoB and CoM. The enzyme consists of three components, HdrA, HdrB and HdrC, all of which contain [4Fe-4S] clusters. Electrons enter at HdrA, which also contains FAD, and are transferred via HdrC to the catalytic component, HdrB. During methanogenesis from acetate the enzyme catalyses the activity of EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase. However, it can also use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity is proposed to take place during Fe(III)-dependent anaerobic methane oxidation. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.",384,1.0,0.00031089137,0.01403639,-0.11382374,-0.00700193,0.099607676,0.02708629,-0.10045442,-0.0004518971,-0.018481283,-0.105461925,-0.07980123,-0.03501354,-0.018951826,-0.04459621,-0.0032270907,-0.029765446,-0.08240394,-0.06132423,0.005541948,-0.0056076148,0.023273844,-0.0049707815,-0.023537751,-0.011099082,-0.07828314,0.009500122,0.057092298,-0.06770995,-0.12628736,-0.06798976,0.03299957,-0.040091198,0.0951671,-0.012203159,-0.020613141,0.07864403,0.0073865675,-0.033392437,0.017107263,-0.0038851304,-0.03376376,0.055855595,0.03290526,-0.07732296,-0.015966756,-0.055643734,0.0461886,-0.02803547,-0.014102498,-0.04834652,-0.031961627,-0.024407612,-0.089888364,0.08244573,0.07798782,0.04088803,0.008591918,-0.056272745,0.047905914,-0.015126083,0.03623892,-0.019048782,0.047412984,-0.019766357,-0.04993956,-0.036684986,0.06729704,-0.10061243,0.0199829,-0.052410968,-0.062020272,0.023268463,-0.045220353,-0.05515882,-0.0031758395,0.050342552,0.024181873,-0.02242385,0.10176586,-0.031084385,-0.058412712,0.00878328,0.07167906,-0.0050375694,0.024729427,0.009042449,-0.048254978,-0.081176125,0.014699529,-0.03233043,0.038967222,0.017652817,-0.010739804,0.032123193,-0.063326254,0.0047973245,0.10760609,0.07160784,0.058928512,0.0069214352,0.017166391,0.08197394,-0.080279075,-0.09006467,-0.038413715,0.011491268,0.07812736,0.19294375,0.0072524995,0.029558219,0.0028397408,-0.011396682,0.09560036,0.013880247,-0.04722589,0.1102537,0.03741952,-0.1155655,-0.03916173,0.040839866,0.07383155,0.009690335,0.12892936,0.024399754,0.05892658,-0.039705645,-0.11599877,6.277817e-33,0.08265881,0.038005553,-0.011488788,-0.024631187,-0.012436921,-0.027364682,-0.10108192,0.022391496,-0.0011974255,-0.011119319,-0.043590993,0.02518216,0.09399925,-0.07730873,-0.10219289,-0.06758642,0.0043661403,-0.016830467,-0.01262939,-0.004555012,0.024236418,0.050739266,-0.016481725,0.07260185,-0.014803393,0.03958137,-0.0009718979,-0.003520159,0.01970443,0.011633306,0.002049428,-0.059703365,-0.11621529,0.0020506654,0.031645615,0.025383187,-0.072908126,0.033737198,-0.1099569,0.0048097507,-0.0036764857,0.046930674,-0.042312153,-0.073705666,0.07928929,-0.028889265,0.014960647,0.15054868,0.021191534,0.09965999,-0.056744263,-0.025374223,0.10359941,0.00703345,-0.0575337,0.0308086,0.017517265,-0.025419852,0.09628271,0.06547837,0.02674737,0.033758413,-0.012658429,0.07221372,-0.035569433,0.050922118,0.037196077,0.010880776,0.027380966,0.092173055,-0.0043020127,0.051672217,0.09065534,0.077359095,0.027133668,-0.03521865,-0.014909989,-0.09892769,0.05548061,-0.011866395,0.046767127,-0.016405908,0.040162,-0.0485646,-0.00750011,-0.038418252,-0.06401484,-0.025148798,-0.026195083,0.052065015,0.020545676,-0.039474595,0.0027152798,-0.033084344,0.017953083,-5.3461303e-33,0.092519395,-0.021508157,-0.012855543,-0.10863604,-0.022984141,0.06946615,0.05917035,-0.02483857,0.011498533,-0.054207698,0.089726605,-0.018310046,0.04702706,-0.048861198,0.054940995,0.052680355,-0.021294367,0.0053669885,0.036164947,0.049459588,0.022795076,0.00399492,-0.08249593,0.0031791534,0.08335555,0.013825378,-0.002214513,0.009465018,0.12029125,0.0058713513,0.0015713728,-0.053035334,-0.045522068,-0.01053974,-0.071084544,0.034023635,-0.09017082,0.038293224,0.037868705,-0.022218952,0.020316623,-0.033313446,-0.0067402152,0.028669996,0.07429524,0.05088631,-0.12981655,0.04349568,0.028723687,0.043982156,-0.0015659224,-0.045205474,-0.03886279,-0.039101064,-0.008222716,0.06570874,0.063080624,0.055316955,-0.02793138,0.016256195,-0.0076280753,-0.051064476,0.060585316,0.03227335,0.000333537,-0.015296617,-0.06004409,0.0433571,0.0117967995,0.054886192,-0.009481077,0.006627754,0.020064676,0.019433768,0.012724813,-0.04395457,-0.014836061,-0.0018676893,-0.04949198,0.046925273,0.0056244778,0.024824677,0.09190214,-0.059858654,-0.05037418,-0.08296921,-0.018608661,0.03537127,-0.010875545,0.007524715,-0.049307663,-0.021849012,0.01306328,-0.008998167,-0.008469643,-4.6424596e-08,-0.011591967,-0.014998425,0.060312733,0.02455108,0.014134928,0.032382797,0.035940964,-0.03203459,-0.0060803574,-0.07183624,0.021128891,0.0697752,0.025224397,-0.059779413,-0.020104298,-0.015761163,-0.05389547,-0.03428159,-0.02152994,0.017986711,-0.019623132,-0.058134455,-0.08818126,0.05064659,0.015673013,-0.06591343,-0.0015900101,-0.012483983,-0.03817404,-0.10098216,-0.06781098,0.06910106,0.04458213,-0.010067955,-0.059989158,0.005164214,-0.025741475,0.01451245,-0.040577594,0.04358885,0.044743065,-0.006628972,-0.04113309,-0.023512512,0.058321018,0.0075674136,-0.033447552,0.019484362,0.024464859,0.012802871,0.020713342,0.00084970245,0.02720337,-0.0115476735,-0.025298178,0.09506143,-0.022289967,-0.037815403,0.014292745,-0.0037760234,0.05652865,-0.013622276,0.07444669,-0.035038166 +1.8.98.5,"This enzyme complex is found in H2-oxidizing CO2-reducing methanogenic archaea such as Methanothermobacter thermautotrophicus. It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD hydrogenase. Electron pairs donated by the hydrogenase are transferred via its delta subunit to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. The reductase can also form a similar complex with formate dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.",384,1.0,-0.07242855,0.027959876,-0.12141889,-0.042191774,0.088585876,-0.021674057,-0.11892083,0.022276677,-0.012702909,-0.07237782,-0.059130095,-0.06031852,-0.016460981,-0.017646922,-0.034193214,-0.023423301,-0.060823027,-0.027666824,-0.013749934,-0.04041258,0.06464767,0.070230395,-0.055669356,0.0031319528,-0.06613494,0.010504236,0.06881612,-0.0066187507,-0.114224575,-0.08021818,0.06484725,-0.06632466,0.079196855,-0.008790019,0.056368638,0.08044122,-0.012058568,-0.07637592,0.04622782,-0.024417996,0.047215328,0.05487002,0.051499363,-0.03423299,-0.015523027,-0.012566323,0.0246081,-0.012138321,0.0052532726,-0.045830313,-0.042852674,-0.03684359,-0.047692243,0.08533701,0.08316136,0.037099954,0.034902673,-0.02330314,0.011368843,-0.034162484,0.030953836,-0.035445057,0.059865784,-0.0556775,-0.0439725,-0.0043039275,0.052055534,-0.08006189,0.027522529,-0.09765617,-0.05075845,-0.0028214795,-0.0540406,0.0061910693,-0.053242445,0.006128295,-0.0002454234,0.0003597858,0.044924065,-0.013001522,-0.0063212733,0.014805257,0.080296434,0.014814839,0.03446317,-0.04358543,-0.034134917,-0.040858336,0.06693835,-0.02599442,0.01148316,0.007502388,-0.016030204,0.006837046,-0.08073025,0.030885678,0.076274574,0.107700825,0.052468717,-0.035378993,0.004349257,0.020178515,-0.03326797,-0.092217766,-0.06356782,-0.03019366,0.06638707,0.1934234,0.009909581,-0.0027247958,-0.015702918,-0.01752799,0.10455442,0.021077897,0.02006627,0.105390735,0.031425655,-0.054047156,-0.035250746,0.01622002,0.090693116,-0.024349684,0.12705626,-0.015152289,0.032433003,0.027460301,-0.180926,7.7169015e-33,0.050664682,0.04439209,-0.025332294,-0.0032052568,0.0042838147,-0.029096352,-0.092984974,0.048679676,-0.008908832,-0.017129865,-0.052300207,0.005252648,0.052353993,-0.08684971,-0.10155435,-0.05951995,-0.006887612,0.0019316043,-0.044780154,0.021825079,0.032535393,0.07065144,-0.011270503,0.030764751,0.043622207,0.057068635,0.024390817,-0.02236066,0.07649043,0.0046616816,0.017020822,-0.14288208,-0.11321458,-0.0088367835,0.07750182,0.0042786268,-0.091677494,0.011311954,-0.075050645,-0.0004585261,-0.031854436,0.005550159,-0.04246627,-0.012696124,0.11186221,-0.023851765,-0.009594722,0.10912979,0.024098916,0.077297986,-0.026383469,-0.036613952,0.10131913,-0.036136582,-0.09358725,0.03164328,0.0047197845,0.011588754,0.10515791,0.07290338,0.025612932,0.06476855,-0.04481319,0.058807425,0.029049331,0.025355253,0.0035026106,-0.008959882,0.04193776,0.075523674,0.0036463228,0.0026112085,0.060328018,0.058364835,0.06305487,-0.07970952,0.0034471806,-0.07493879,0.020449651,-0.007612309,-0.0029015904,-0.026723865,0.051646937,-0.05491805,-0.021218048,-0.04067232,-0.054718256,-0.014536153,-0.028170876,0.025196113,0.045671284,-0.03419322,-0.03558071,-0.03574794,0.018677816,-6.543813e-33,0.08110347,-0.05554643,0.0037998066,-0.11070492,-0.011404977,0.096466005,0.032079957,-0.030853136,0.03347885,-0.062378153,0.11200782,-0.013982696,-0.017917667,-0.044598285,0.0440662,0.048898134,-0.013271654,0.04442892,0.025395509,-0.0078034983,0.050943308,0.011701586,-1.5348774e-05,-0.01966563,0.021339897,0.014897993,-0.0039335825,0.06760371,0.10741661,0.028686304,-0.04646411,0.011550594,-0.036894165,-0.013400422,-0.106770046,0.03357245,-0.093838505,-0.01937367,0.0061171288,-0.02109476,0.01861002,-0.010104071,-0.03196925,0.05458488,0.039576072,0.059822585,-0.119772494,0.060017563,0.045626897,0.02924727,0.002999155,-0.056926973,-0.05782344,-0.024127383,-0.010659695,0.009109281,0.042173922,0.034195416,-0.040476397,0.018629802,-0.009751125,-0.0736733,0.031862468,0.1004653,0.0037163561,0.009400689,0.0373267,0.022684203,0.027790058,0.06488967,0.033943027,-0.005786584,-0.0060377517,0.026777087,0.0034044026,-0.022689495,-0.043097276,0.06341956,-0.018873619,0.017269714,0.037164547,-0.01069654,0.06574084,-0.04675504,0.0074269315,-0.0759318,-0.005318324,0.063687325,-0.040485963,0.01516177,-0.057006415,0.012509425,-0.024157586,0.038781136,0.026253538,-4.519353e-08,0.033343423,-0.05418011,0.0604148,-0.051437017,0.07148122,0.029426718,0.0072866553,-0.015875936,0.011634151,-0.0183236,0.011978874,0.039453372,0.01925684,-0.056477,0.0064316904,0.046389565,-0.0223387,-0.022440532,-0.007644511,0.05318727,0.03188556,-0.048923194,-0.10237942,0.05331324,0.019698476,-0.061788555,-0.0034829148,0.004875612,-0.0054518804,-0.07588109,-0.020221984,0.07623428,0.050822455,-0.05517422,-0.071637206,-0.008413894,-0.032983787,0.013759065,-0.039017253,0.0197272,-0.0032792343,0.00554889,-0.053187642,-0.024687255,0.083770975,0.026145311,0.005192391,0.01296911,-0.008211938,-0.010691455,0.0188185,0.0043398826,0.02510234,-0.04864477,-0.10695155,0.06552495,-0.004800311,-0.045838863,-0.018143816,-0.0038251418,0.068285525,-0.015794514,0.09979693,-0.00968346 +1.8.98.6,"The enzyme is found in formate-oxidizing CO2-reducing methanogenic archaea such as Methanococcus maripaludis. It consists of a cytoplasmic complex of HdrABC reductase and formate dehydrogenase. Electron pairs donated by formate dehydrogenase are transferred to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.",384,1.0,-0.04808038,0.033665612,-0.12062098,-0.056936543,0.06052159,0.003522486,-0.11544889,0.02406387,-0.025108758,-0.06335068,-0.05683232,-0.060003035,-0.031949654,-0.012427275,-0.07398468,-0.021548972,-0.07813666,-0.023656832,0.0022644305,-0.037661064,0.06181415,0.086643755,-0.04423395,-0.0158579,-0.043356348,-0.020296512,0.05499441,-0.003257109,-0.119513206,-0.08706117,0.05080207,-0.048032083,0.07555255,-0.014732695,0.053199727,0.06812886,-0.00024349033,-0.070227675,0.06695526,-0.014683848,0.033977233,0.06294887,0.018327096,-0.020536542,-0.04275369,-0.009982698,0.035869725,0.02653854,0.002683134,-0.02484582,-0.040718257,-0.020246534,-0.05743419,0.1068918,0.107948706,0.024844836,0.037961688,-0.04705542,-0.0011241128,-0.03053194,0.012904077,-0.01645154,0.030986877,-0.030200932,-0.053801466,-0.017455706,0.062330335,-0.08324629,0.029093623,-0.10798971,-0.05099155,-0.0058481004,-0.037474643,-0.003263995,-0.04924736,0.050818507,-0.003061252,-0.020323433,0.028854834,-0.017466828,-0.0019696376,0.012880535,0.078033395,0.044495884,0.064196706,-0.05390217,-0.0514815,-0.036909744,0.04059567,-0.03170068,0.038505524,0.008395272,-0.0046670954,0.00218403,-0.075828746,0.013094596,0.08937799,0.097996525,0.05211146,-0.023119472,-0.022620367,0.0136227,-0.014225863,-0.100554936,-0.087718464,-0.039360773,0.07720651,0.19201404,0.00894023,-0.0029130897,0.006474037,-0.010228816,0.08256941,0.012274089,0.0047336593,0.10503591,0.03557728,-0.09056658,-0.04236772,0.00034737863,0.07013755,-0.015487603,0.11277868,-0.006308012,0.016424848,0.029153805,-0.16025357,7.8860735e-33,0.051245827,0.03175417,0.00018197572,0.0074047274,7.22272e-05,-0.003397307,-0.0984106,0.033149973,0.0045410614,-0.03627505,-0.06026557,0.021606294,0.08671915,-0.08363318,-0.09698485,-0.061140798,0.01652602,0.00123353,-0.0418585,0.028489906,0.028155932,0.07379008,-0.008424655,0.02790754,0.050043676,0.06702538,0.0061433595,-0.012327434,0.064059496,0.0013441457,-0.010328804,-0.13458939,-0.0870075,-0.022543684,0.06636158,0.013923248,-0.09183889,0.01640737,-0.096970476,0.036638346,-0.009134551,0.018645152,-0.018106371,-0.034865808,0.09249838,-0.03625605,-0.0227546,0.1253575,0.03304814,0.09925435,-0.0252554,-0.026721697,0.089031,-0.0130437035,-0.0865768,0.038869884,-0.008278064,-0.00975288,0.10482316,0.06511748,0.04210776,0.06457681,-0.039937098,0.034670707,0.023542427,0.011538392,-0.010456332,-0.024957841,0.017522128,0.095364995,-0.013193196,-0.0023334862,0.06426738,0.047178425,0.047766414,-0.07432332,-0.014327424,-0.06402929,0.049240433,-0.020030743,0.009160353,-0.019373236,0.03598725,-0.05105391,-0.040054068,-0.018761994,-0.05218625,-0.006326481,-0.03719318,0.045545645,0.0515687,-0.054401275,-0.043189183,-0.046560552,0.021312615,-6.967038e-33,0.08043797,-0.04555223,0.0129487,-0.10876828,-0.0047641415,0.1126713,0.036710277,-0.03522597,0.03474481,-0.045348223,0.11597321,-0.00371986,-0.019629795,-0.047542755,0.034112897,0.05072102,-0.01558033,0.037120555,0.028577186,0.0069999285,0.0693827,0.022289664,-0.0028951361,-0.031187842,0.03790671,0.00476815,0.013499289,0.06559084,0.112584725,0.019645967,-0.043750178,0.012941903,-0.043868136,-0.026336499,-0.09568846,0.053903546,-0.09646218,-0.0062052007,0.020045856,-0.029440623,-0.00027602678,0.01131562,-0.016618375,0.06791515,0.056467,0.06701119,-0.13096422,0.07147259,0.06317294,0.018726407,0.011879272,-0.040980887,-0.058071215,-0.028801946,-0.026545497,0.03537018,0.024376364,0.03846163,-0.03953077,0.020505423,-0.008295259,-0.06324536,0.03920022,0.07652819,-0.004493142,0.007149823,0.011841734,0.03289353,0.023054983,0.0611378,0.009127336,-0.006956627,-0.011790084,0.03289884,-0.00904945,-0.02149675,-0.07685499,0.0517225,-0.009315302,0.027030338,0.028739687,-0.006933391,0.05859871,-0.01567657,-0.017270615,-0.07982887,0.00532846,0.045397494,-0.037498064,0.0067183063,-0.05556629,-0.009216724,-0.02459497,0.02663893,0.022504367,-4.6425896e-08,0.027682822,-0.059919354,0.06524724,-0.04376094,0.034980148,0.026300712,0.03442238,-0.00031593468,0.018128179,-0.032562573,0.042143047,0.05637551,-0.0008625727,-0.03193964,0.00013422768,0.059500545,-0.04372504,-0.02802153,-0.017027099,0.033937085,-0.0018734651,-0.04596614,-0.09130175,0.051254157,0.008929852,-0.057018057,0.011984172,0.01470311,-0.0052175475,-0.08042832,-0.02004727,0.06419956,0.04033132,-0.06595233,-0.06836058,-0.024089528,-0.06719841,0.03558841,-0.045016363,0.04866563,0.0049920357,0.010314276,-0.04961075,-0.0070223333,0.06781751,0.011434035,-0.012219913,0.03975477,-0.013690309,-0.006953139,0.026286164,0.0151251955,0.039953124,-0.04865394,-0.114909805,0.05006127,-0.008611706,-0.043192927,-0.010743293,-0.019334419,0.048651785,-0.011830904,0.112174384,0.014522824 +1.13.11.84,"The enzyme, characterized from the plant Crocus sativus (saffron), acts twice, cleaving 3beta-hydroxy-beta-cyclocitral off each 3-hydroxy end group. It is part of the zeaxanthin degradation pathway in that plant, leading to the different compounds that impart the color, flavor and aroma of the saffron spice. The enzyme can similarly cleave the 7-8 double bond of other carotenoids with a 3-hydroxy-beta-carotenoid end group.",384,1.0,-0.06638265,-0.05713258,-0.13208644,0.02827558,0.12148375,0.07423162,-0.06567721,0.023186179,-0.022340186,-0.07615722,0.03275919,-0.024025876,0.048087962,-0.039279785,-0.055027366,0.016761346,-0.0768988,0.015716195,-0.017703919,-0.07765376,0.09981474,-0.011118369,-0.013134724,0.04351429,0.103836715,-0.011810214,-0.012178876,-0.013791155,-0.014526296,0.0043038772,0.0009341316,0.039102472,0.030890312,-0.020903826,0.0434197,0.0709802,-0.08178873,-0.07694434,0.019937092,0.036373533,0.05346968,0.017650964,-0.008754188,-0.04888548,0.009743365,-0.045355473,-0.09185405,0.01656697,0.03244829,0.029913353,-0.039121255,-0.05524139,-0.10495591,0.028128449,-0.02535357,0.029332908,-0.10634302,-0.008289898,0.05019776,0.09507554,0.055128887,-0.016640872,0.038611997,0.018781016,0.049330525,-0.06709527,-0.092027515,-0.059878208,0.01153958,-0.011756695,-0.00556324,-0.02713113,0.001616837,-0.03713008,0.009845878,0.0114278365,-0.022714248,-0.0291295,-0.027738025,-0.055043228,0.012504902,0.03564784,0.048787903,0.0754169,0.059707426,0.031346727,0.028443135,-0.01749584,-0.0056271865,0.029024716,0.046468306,0.004519166,-0.02773912,-0.04850681,-0.0303495,0.072845764,0.049662407,-0.08296599,-0.0229827,-0.013399799,-0.013763561,0.023530917,-0.020552227,-0.10126787,-0.019683335,0.031879734,-0.019415233,0.048104927,-0.05654544,0.007966635,-0.026397746,0.03558313,0.0013945313,-0.08043245,-0.04866648,0.09340347,0.01062196,-0.014467642,-0.10104612,0.04291204,0.032465834,-0.056892477,0.006744756,-0.002845496,0.03619221,0.02188753,-0.072563395,2.0422857e-33,-0.010840275,0.0383905,-0.022499021,-0.030997135,-0.010025219,-0.030133171,-0.094360225,0.07758089,-0.10183225,-0.040253386,-0.08607606,0.026469966,0.019699395,0.02083013,-0.051875003,-0.035763524,0.009848948,-0.017765975,0.03642761,-0.0333876,-0.012763309,0.062224198,-0.031125698,0.012550732,-0.05871144,-0.044712566,-0.0028900611,0.07470832,0.0030191431,0.004780548,0.070169814,-0.014714976,-0.07266845,0.02531017,0.06602484,0.03305718,-0.03465709,-0.07866859,-0.09100926,0.06565282,0.011626966,0.08807553,0.021433959,-0.022338377,-0.0041273404,-0.0445605,0.029403152,0.04339317,0.10012533,0.04346397,-0.009587453,0.024645744,0.09575748,0.02131491,-0.07598217,0.063908964,0.03929226,-0.03812297,-0.007916258,0.033209104,-0.035272617,-0.004958836,-0.056419466,-0.0013689594,-0.0201396,0.05469616,-0.14203696,-0.06437003,0.03817719,0.01244448,-0.050576285,-0.023297423,-0.043895543,0.035679065,0.027287612,-0.023917431,0.01426829,0.023407584,0.033354327,-0.038347863,-0.0125593385,0.009970282,0.06296463,-0.011433734,-0.04469471,-0.05829375,-0.10156568,-0.029709168,0.07611065,0.011126845,0.023621244,-0.073481224,-0.009854278,0.014222385,-0.0011879058,-2.1403625e-33,-0.004909667,-0.087834544,0.06375936,0.030083949,-0.008685354,0.08761129,-0.02344442,-0.079028115,-0.00989968,0.040070653,0.089231245,0.0629432,0.032294147,-0.07779277,0.0648759,0.07500302,0.105592154,0.09757679,-0.014630805,-0.02828063,-0.038739346,0.11044817,0.039959975,-0.040501375,-0.02686606,0.049799442,0.027148543,-0.013601751,0.05237347,0.049523838,0.0043656654,-0.10515158,-0.10469198,0.05482284,0.0048840814,0.008237806,-0.031832553,0.008326754,-0.035394542,0.06310974,0.025017545,0.0052182646,0.030411394,0.045394875,0.10427419,0.01564748,-0.048551764,0.09442294,-0.013122087,-0.004975019,0.04326027,-0.052241217,-0.022786302,0.032880735,0.081914976,0.014889566,0.027206479,0.019277511,-0.048684884,-0.018463604,0.0646274,-0.0203334,-0.062027797,-0.01653684,0.0470953,0.00992783,0.011700275,0.043081347,-0.010863559,-0.017455056,0.06247719,0.03623144,0.0012141635,0.032339044,-0.031334657,-0.045454863,-0.07237612,-0.031179072,-0.04825107,-0.003121985,0.039685667,0.012445154,0.05033009,-0.04153153,-0.06591863,0.00019126725,0.0035229442,0.11986632,0.11700819,-0.056503925,0.00010978649,0.025905192,-0.03420232,0.07103724,0.10538228,-4.017887e-08,-0.012076398,-0.036015496,0.05673251,-0.047392808,0.001630908,-0.07223784,-0.0071471985,-0.038335707,0.08832883,-0.029711518,-0.051107906,0.09205938,0.027018568,-0.03180495,-0.017745141,0.01709727,0.032372452,0.05093398,0.0114918575,0.1292994,-0.0815491,-0.036461778,-0.058037877,-0.003734849,0.0155849485,-0.10912903,0.013178487,0.09210611,0.0042552785,0.017394064,0.07332299,-0.030587962,0.01933205,-0.029107604,-0.09833864,0.03266938,-0.017456492,0.0033550737,0.008279411,0.058953375,0.055382557,-0.033866443,-0.0007202814,0.013623395,-0.07812092,0.006227114,0.021307549,-0.005986434,-0.002277084,0.042302232,-0.037931502,-0.067718014,-0.039472945,-0.044612627,-0.008911131,-0.12831263,0.04268946,-0.04429748,0.027956929,-0.06959397,-0.0070357365,0.061498336,0.14115193,0.033887032 +1.14.13.239,"The bacterial enzyme is a complex consisting of a reductase and an oxygenase components. The reductase subunit contains a flavin and a plant-type ferredoxin [2Fe-2S] cluster, while the oxygenase subunit has two domains, a Rieske-type protein in which a [2Fe-2S] cluster is coordinated by two histidine and two cysteine residues, and a domain with a catalytic mononuclear iron centre [4].",384,1.0,-0.052125946,-0.07640845,-0.118584365,0.048081618,0.12347435,-0.014825906,-0.06590539,0.045905575,0.03702218,-0.14106673,0.00019801037,-0.06900609,-0.006571039,0.0421511,-0.03771764,-0.05884126,-0.10089884,0.007646624,0.002978825,-0.03293973,0.028072039,0.047145255,-0.002772132,-0.03436139,-0.033013456,0.030415468,0.07280561,0.020765755,-0.069544904,-0.09548902,0.02107651,-0.048067335,0.093545675,-0.051516864,0.060459673,0.088365875,0.06553972,-0.070334725,0.041332413,-0.0241275,-0.0122946305,0.035436872,0.088175416,-0.010061828,-0.01929234,0.028367719,0.025476305,0.0049395403,0.053578146,-0.012679517,-0.07233439,-0.051452827,-0.05466273,0.0976253,0.035707165,0.018183995,-0.0031821523,-0.025434462,-0.01955279,-0.04534063,0.08132887,-0.03867489,0.057565928,0.0016816376,-0.00066095125,-0.02885252,0.0014757619,-0.061183147,-0.05976186,-0.08194899,-0.0048319907,-0.011813651,-0.02129128,0.04644864,0.009805179,0.009393009,0.02023715,0.028468661,0.036157075,0.031236056,-0.018206097,-0.017628584,0.054575555,0.07984875,0.010544727,-0.053661287,-0.030606205,-0.03418671,0.020464413,0.05730173,0.015398953,0.035778917,-0.002728387,-0.08767671,-0.052763876,-0.016743975,-0.007170269,0.07182671,0.017486433,-0.0202754,-0.07097127,0.03419258,0.024066424,-0.106063016,-0.014716611,-0.02201508,-0.028502652,0.1137834,0.07181935,-0.037419792,0.0435047,0.024104,0.076986484,-0.03997591,-0.0064644692,0.05140289,0.036297347,-0.031079628,-0.109818414,0.07657392,0.055747293,-0.027314393,0.04268798,0.016398301,-0.009610964,-0.07501595,-0.17993896,1.2875118e-33,0.023210669,0.0036977062,-0.03699562,0.011396307,0.00093498675,-0.010152293,-0.05063527,0.011191029,-0.01830301,-0.0051126713,-0.06885781,-0.038250342,0.060841452,-0.03153891,0.019069023,-0.07727963,0.015933007,-0.025849866,0.029153144,-0.03584455,0.06853665,0.07987342,-0.00031450117,0.027994378,0.09566169,0.039515894,0.021082977,-0.031191893,0.006757502,0.007236643,0.036945663,-0.08424513,-0.11018364,0.015507887,0.08621851,-0.06071304,-0.011691592,-0.02063956,-0.034435444,-0.01651463,-0.02132048,0.04537272,-0.023960311,-0.04144218,0.11240819,-0.04902401,-0.038708966,0.12204407,0.058970436,0.10867341,0.003936848,-0.02932121,0.10757257,-0.024425933,-0.035525806,0.055944122,-0.0030088208,0.05248001,0.007245056,0.047804788,0.029173573,0.066332616,-0.050283615,0.01831652,-0.024828235,0.058215477,-0.007260585,-0.072607785,0.08483357,0.13489436,-0.0034577881,0.027932234,0.0290701,0.04625087,-0.01908374,-0.07374182,-0.06344851,-0.024026357,0.07297583,0.010867451,-0.02160353,-0.028941497,-0.053999282,-0.02792452,-0.05289946,-0.027125115,-0.0481662,-0.0018344724,-0.077746674,-0.0010490378,0.060024068,-0.035050165,-0.04339381,-0.05650795,0.014910468,-2.617045e-33,0.05503726,-0.120036654,0.050676644,-0.08907918,-0.06483149,0.06384936,0.003351973,-0.025367146,-0.02383191,0.024107812,0.04755425,0.001207562,-0.04557186,-0.029207116,0.023918021,0.051555183,0.0047361096,0.04504245,0.042206407,-0.010917176,-0.0194517,-0.0011521798,0.053597115,0.026198404,0.0031247057,0.046784185,-0.05681824,0.073090754,0.0602978,0.043188594,-0.043842457,-0.026238691,-0.024810994,-0.075304024,-0.07442688,0.0187524,-0.042864323,-0.05393279,0.025552025,-0.030002259,0.06881674,0.0028600907,-0.038084667,0.099342756,0.018890727,0.040579297,-0.06361842,0.051483482,-0.037968457,-0.048675288,-0.03812988,-0.05597676,-0.015332013,-0.010481274,-0.032468934,-0.035282265,0.051126346,0.039249964,-0.039105367,0.001745491,0.01634131,-0.11127188,0.026362387,0.13069557,0.018632006,0.02875053,0.031302374,0.01974876,0.019923424,0.04208293,0.033867955,-0.03811051,0.06385956,0.02405216,-0.03837326,-0.012508565,-0.0029968268,0.026922744,0.01806363,0.0069462494,-0.010303574,-0.012798397,-0.011678898,-0.045453597,0.057299174,-0.058576792,0.037106544,0.07602779,0.042577513,0.0024183893,-0.023218744,0.03599687,0.01786406,-0.013833668,0.035946228,-4.2043276e-08,0.009517555,-0.099967495,0.047840483,-0.06456906,0.039840564,0.03379824,-0.0423656,0.0020974455,-0.032270014,0.06508434,0.025663573,0.10977912,-0.04722979,-0.07852632,0.062048253,0.026171586,-0.0073972084,0.016274858,-0.0066645914,0.03950657,0.0064179,0.0023528924,-0.13158958,0.055449862,0.008745418,-0.06363688,-0.06289361,-0.013994468,-0.0012296733,-0.03778984,0.0039896197,0.030260244,0.020680115,-0.03111476,-0.14908536,-0.0733731,-0.025186216,-0.037609737,-0.033634894,-0.0049496633,0.016824797,0.045843467,-0.06718115,-0.024882352,-0.016452063,0.054876078,0.051582325,0.0052473648,0.005040932,-0.038057312,0.011964845,-0.025939219,-0.014456117,-0.00913422,-0.13120769,0.055632092,0.0033122625,-0.013683838,0.021908006,0.023829296,0.013232168,0.036953416,0.12811784,-0.031544253 +1.14.14.55,A cytochrome P-450 (heme-thiolate) protein. ,384,0.99999994,-0.076557726,0.021021307,-0.01655247,-0.040306345,0.03260365,0.04243468,0.027800782,0.12225458,-0.017934727,0.0028029543,-0.021859327,0.0024067222,-0.028989835,0.034812473,-0.005775227,-0.0036770543,-0.018071055,-0.02581958,-0.00050043897,-0.08541288,-0.03127308,0.038724277,0.0182921,0.02636574,-0.03803794,0.019050516,0.053345747,0.1011325,-0.05031041,-0.024114562,-0.07105179,-0.028481973,0.011488101,0.0037069744,0.0017946754,0.09023362,-0.09615736,-0.066119276,-0.005057367,-0.08180935,0.11370241,-0.007606547,-0.101195574,0.056546967,-0.012107997,-0.022804532,-0.015158996,0.028835203,0.036286253,0.011536441,0.017873617,-0.0390311,-0.04309165,0.033640426,-0.04743065,0.0057979627,0.008518574,0.015373931,0.0057615745,-0.050166022,-0.07919005,0.04527247,-0.004830999,0.02180761,0.052464675,-0.04126035,-0.018201256,0.0029574623,-0.03388583,-0.052162375,0.0005637807,-0.059881117,-0.015335886,0.047584243,-0.085852794,0.05028557,-0.013467036,-0.008354972,-0.0040431856,0.02318205,0.023546888,0.032171153,-0.0015174436,0.13482414,0.039865047,-0.020148432,-0.01658746,0.06395693,-0.08815714,-0.06465278,-0.012753627,0.04495596,-0.0297044,-0.01611324,-0.09985071,0.03490699,0.010771087,0.025702203,-0.01612607,-0.019852757,0.0802109,0.07059758,0.03997678,-0.0944842,-0.04570625,-0.011134278,0.012920966,0.07453531,0.06885478,-0.10593755,-0.03363142,-0.032208186,0.01974633,-0.044115704,0.021073613,0.07258475,-0.0418896,0.011906556,0.0068556946,-0.015799165,-0.05177738,0.017995834,0.011036891,-0.0028119609,-0.053087402,-0.022995746,-0.08626211,-1.888511e-33,0.07134915,-0.0039801523,0.014120266,0.05447009,-0.033561368,0.010767098,-0.06441382,0.059594937,-0.025353353,0.028828707,-0.045717277,-0.09199325,0.025052333,-0.047769226,-0.033841494,-0.016140757,-0.0553254,0.059136085,0.027085397,0.009261081,-0.07858097,0.008559812,0.0009043721,-0.028876504,0.014008461,0.10062849,-0.056679685,-0.031399373,0.008493546,0.0074117472,-0.066748835,-0.03639391,-0.040037878,-0.05514285,-0.006893888,-0.034346342,0.017103404,-0.0062881135,-0.061202563,0.02794562,-0.011271369,-0.047519457,0.014285792,-0.07217621,0.064593524,-0.026908876,-0.12465964,0.015593896,-0.04986793,0.027482746,0.065975055,-0.110297166,0.098831825,0.05774575,-0.095820464,0.0034779955,-0.00829126,0.048915554,-0.010033903,0.051661454,0.14718938,0.08517257,-0.05849207,0.07458315,0.048358094,0.062204238,-0.04666864,-0.028573643,-0.021477783,0.15119852,-0.020945057,0.0064557916,0.095174916,-0.068309814,0.033074196,-0.00057124055,-0.0067515858,0.08380301,0.05710021,0.07743601,0.029423408,-0.050958063,-0.04284672,-0.018648922,-0.008205466,-0.01471776,0.10262148,0.009596691,-0.0025895901,0.04047912,0.06642099,-0.10366235,-0.0066758483,-0.008848656,-0.05483594,1.9187184e-34,0.07791061,-0.064554155,0.0160926,-0.0666495,-0.044080667,0.052029386,0.032278433,-0.024520375,-0.0517679,0.012268372,0.1491134,-0.0692142,-0.02065564,-0.013292579,0.011444492,0.017982706,-0.06380957,-0.0053185266,0.005193084,0.067196734,-0.023129549,-0.056165878,0.037482936,0.023095455,0.02832133,0.039098576,0.018251639,-0.019004798,0.065403745,0.0074452246,-0.060878243,0.06648712,-0.08038039,-0.061106335,-0.04264281,0.03171895,0.03463174,-0.01947865,0.019574806,0.0053710826,-0.04674012,0.09823597,0.03099105,0.07098596,0.026661307,0.12061904,-0.04433869,-0.056289203,-0.030469758,-0.017757442,0.0531803,-0.014810648,-0.037629746,0.04900653,-0.077692054,0.0015392979,-0.03863473,0.034204975,-0.019629156,-0.043892007,-0.03648158,-0.022819055,-0.022991354,0.09737709,-0.009800515,0.07304971,-0.033150822,0.035406984,0.0059652957,0.0040141176,0.0069941347,-0.0060487716,0.08036033,0.07848875,0.028785488,0.01845152,0.033433687,0.014439612,0.08442977,0.01590551,-0.015155269,0.025966492,-0.10963736,-0.0336635,0.012854237,-0.060360778,-0.09711439,0.102968164,0.06217691,-0.038203046,-0.03606107,0.07878413,-0.04779019,0.045995995,0.02633033,-2.2297428e-08,0.016974846,-0.08381897,0.004974508,-0.016902708,0.04014164,0.048908774,0.029055748,-0.010770385,0.03487259,-0.010776895,0.0415482,0.020745121,-0.058542807,-0.03571438,0.0052323844,0.028874232,0.00016745339,-0.004526292,0.070312105,0.021178273,-0.034962628,0.0075812964,0.0018358956,0.016059795,0.059302032,-0.08334029,-0.0015173148,-0.015380438,0.037175838,-0.0044074715,0.011277357,0.03956317,-0.057705883,-0.012825892,0.09734656,0.037359748,-0.044605613,-0.02571888,-0.045587547,-0.0036487838,-0.022025798,-0.0475482,-0.0788328,-0.05563893,0.031953637,-0.034702126,0.07980083,0.059474077,-0.04003338,-0.06406798,-0.067047626,0.0013546454,0.007274123,-0.08580903,-0.10747454,-0.007040259,0.07323971,-0.08430555,-0.055636585,-0.10075465,0.02169638,0.0053255167,0.13734174,-0.011846996 +1.14.14.56,"A cytochrome P-450 (heme-thiolate) protein. The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.14.55, quinine 3-monooxygenase, EC 1.14.14.57, taurochenodeoxycholate 6-hydroxylase and EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming).",384,0.99999994,-0.05537428,0.009912456,-0.018305887,-0.028286275,0.054246496,0.0031059755,-0.039750498,0.09622063,-0.01254487,0.003401037,-0.025635617,-0.009508131,-0.059828185,0.037963886,-0.013942703,0.0360677,-0.06431625,-0.016786695,0.04175696,-0.07514543,-0.02626248,0.038248036,0.0067364434,0.0022512907,0.017814146,0.034148715,0.06624897,0.06491794,-0.055442605,-0.018712081,-0.03290889,-0.01223887,0.052443575,-0.028853877,-0.04593627,0.10951663,-0.07867895,-0.045865398,-0.022225251,-0.026789138,0.04018973,0.0046767984,-0.08340623,0.045265067,-0.0154412575,-0.06171842,-0.01873535,0.004031954,0.00045152486,0.019415522,-0.004847496,-0.02673538,-0.07303802,0.043970443,0.0068492834,-0.0063072084,0.001295275,-0.05424441,-0.0327265,-0.048641555,-0.07339952,0.01334643,0.0040413532,0.02721903,0.029467503,-0.032788012,0.025467921,-0.04354131,-0.040309474,-0.07147218,-0.051900867,-0.110596746,-0.019087778,-0.0033014931,-0.10343278,0.057398804,-0.029840775,-0.03572767,0.007929164,-0.0061492375,-0.01075596,0.005193852,0.011982309,0.096022524,0.07873762,-0.055764925,-0.03922662,0.010625858,-0.07105603,0.007466909,0.006042026,0.055882975,0.022229627,-0.037543908,-0.055514175,0.057878185,0.018825222,0.0634195,-0.0147340605,-0.027530568,0.046980627,0.06980831,-0.065785594,-0.0677669,-0.025269132,0.028734995,-0.0016515341,0.11471164,0.03815622,-0.059300877,-0.043548044,-0.04195414,0.029759893,-0.024316171,0.05167165,0.10611213,0.057531677,-0.0062628835,-0.026850788,0.0008653726,-0.07370473,0.019946711,0.051607188,-1.7954995e-05,-0.019458171,0.001867749,-0.04347379,1.6910807e-33,0.09495351,0.033949967,-0.025711507,0.021939643,0.003649777,0.030086871,-0.038294785,0.07151921,-0.0015676909,-0.016522538,-0.049786173,-0.010194669,0.043634985,-0.006435461,-0.03048267,-0.0033185205,-0.014730305,0.039125185,0.09552591,-0.0024272026,-0.07834022,-0.05331508,-0.024104029,-0.004800716,0.011432855,0.08315961,-0.046857327,0.0012057017,-0.04175101,-0.0014702684,-0.089503676,-0.02837546,-0.055124555,-0.030163616,-0.044990882,-0.006734612,-0.015854958,-0.002405525,-0.084555775,0.057864193,-0.03617423,-0.042526852,0.023097653,-0.113017045,0.047850505,-0.025553282,-0.13354604,0.061277635,0.0028812012,0.035951637,0.06619957,-0.062907584,0.11320077,0.017580008,-0.06755309,0.042166468,-0.015294978,0.022871707,0.021185461,0.073093645,0.107394494,0.086367816,-0.06125241,0.07917006,0.020695701,0.034181543,-0.07513926,-0.031276725,-0.0922926,0.16332828,-0.01709219,0.030839873,0.09011578,-0.04275316,0.021442115,0.013914614,-0.026765496,0.07553034,0.007573841,0.045719694,0.023337008,-0.0344662,-0.018189527,-0.03753908,-0.0024261572,0.005400801,0.059244603,-0.015218807,-0.00034631035,0.040277883,0.0357712,-0.104878426,-0.026567593,-0.03584944,0.0052754455,-2.3209291e-33,0.07250337,-0.071730115,-0.0074404883,-0.10073432,-0.023790708,0.060581747,0.021903854,0.0009265156,0.012274167,-0.0054731043,0.08215761,-0.059522267,-0.014393712,-0.055049468,0.03577137,-0.022766978,-0.02869771,0.030253561,0.019361507,-0.00720717,0.0045263045,0.033603176,-0.001629878,0.03702906,0.05135956,0.021718552,-0.021951506,-0.010430738,0.086615995,0.032856647,-0.100418,0.07673429,-0.019748662,-0.0038134449,0.03430557,0.056037504,-0.049170125,0.01272592,0.03296334,0.028325778,-0.0249562,0.06571878,-0.0061075147,0.1343642,0.03327609,0.08897317,-0.10262057,-0.055478007,0.016208189,-0.048991658,0.053525094,0.03267172,-0.020257043,0.034726817,-0.021179896,0.027621083,-0.008558377,-0.0071698385,0.06538138,-0.0640424,-0.030618818,-0.009414143,-0.009596078,0.04842297,-0.014555391,0.05427908,-0.08074177,0.016185606,-0.005246307,0.020285133,0.048902635,-0.03347185,0.037955176,0.06894949,-0.022393035,0.0050530504,0.025364283,0.014610786,0.035789542,0.027990205,0.05265996,0.015724199,-0.021841437,-0.022177923,-0.057325453,-0.10754507,-0.07483318,0.1577472,0.014551841,-0.023500673,-0.01642978,0.061249055,-0.080426484,0.046894703,0.03239956,-4.7541683e-08,-0.008991994,-0.07752656,0.054331668,0.032192685,0.012584586,0.078801885,0.071602084,-0.01788942,0.06934824,-0.021360887,0.02326205,0.090727314,-0.026695678,0.008599956,0.035295606,0.050072845,-0.03905172,-0.006873853,0.027667997,0.029275492,-0.07343909,0.0036745924,-0.027100518,0.049346216,0.026374001,-0.11026614,-0.0058503416,-0.005701165,0.01017476,-0.01367639,-0.03233483,0.034637515,-0.040111102,0.033642,0.015904693,0.020269824,0.0084542725,-0.057341646,-0.025587054,-0.015526352,-0.072564974,-0.071362704,-0.115690954,-0.04333458,0.07004692,-0.023903755,0.038730036,0.041518673,-0.02128536,-0.030533459,-0.052427918,0.012201674,0.0047386168,-0.06860885,-0.06586627,0.027875913,0.059684675,-0.0904657,-0.032234628,-0.13399348,0.058912642,0.019482689,0.23567355,-0.04541566 +1.14.15.24,Requires ferredoxin and iron(II). Also acts on other carotenoids with a beta-end group. In some species canthaxanthin is the preferred substrate.,384,1.0,-0.020673964,-0.04042357,-0.09997034,0.04015051,0.07573584,0.018551886,-0.018766008,-0.014035224,0.0086036185,-0.06487811,0.046787646,-0.06978078,-0.04652888,0.042700887,-0.010185047,-0.008114564,0.013247578,-0.021177588,0.0394555,0.022520794,0.061133355,-0.009962005,0.013482264,-0.045099575,-0.03087125,-0.055664666,-0.043584775,-0.016482037,0.024207039,-0.066119514,-0.08583795,0.053135443,0.045925476,-0.044345416,-0.044051513,0.0784409,-0.058553483,-0.02569318,-0.04136555,-0.0017408262,0.011028938,-0.04821625,0.0065758545,-0.012522523,-0.020710897,-0.079233356,-0.008862812,0.0056299698,0.038429953,0.05945412,-0.06865244,0.012813177,0.012121297,-0.0007650113,0.008355502,-0.0035426165,-0.050523333,-0.0073329946,0.024269182,0.015206449,0.07201565,-0.033235393,0.001143596,-0.045899097,0.04655101,-0.00583045,-0.033849712,-0.011097487,-0.03566933,-0.06919651,0.059803903,-0.009322485,-0.035298374,-0.046243094,-0.009374569,0.04969591,-0.00092329993,-0.041484978,0.0130985435,0.00020096732,-0.016901266,0.06209126,0.022956902,0.06983272,0.06857492,0.056261655,-0.047091912,0.018080724,-0.121363364,0.074141674,0.025568191,0.024286374,-0.018999977,0.050909977,0.02334103,0.01154433,0.09720587,-0.0723288,-0.0063131466,-0.04937638,-0.041731153,0.011444962,-0.050941654,-0.033677753,-0.051166076,-0.008207369,-0.0470429,0.032056406,0.02797298,-0.020354314,-0.003657334,0.003996985,0.06236004,-0.005590234,-0.012373961,-0.002725566,0.016573247,-0.057588387,-0.071734294,0.07422844,0.01217487,0.04897929,-0.017093537,0.06772296,0.029746054,0.03006728,-0.05094448,8.259494e-34,0.08312858,0.082469895,-0.010201711,0.026086045,-0.02008704,0.008081115,-0.07861709,-0.065684035,-0.012141004,-0.08664431,-0.09426405,-0.061237145,0.019474452,-0.03527146,-0.0052046995,-0.06378749,-0.012385092,-0.042206887,0.054432143,-0.009098575,-0.007403837,0.0754839,-0.05367305,-0.014966524,-0.02790033,0.06582856,-0.02254165,0.00384453,-0.0030681388,0.0019485271,0.098308235,-0.0934595,-0.07397526,0.038913406,0.10373838,-0.002287373,-0.009194357,-0.048531648,-0.1517424,0.0065713357,0.023954684,0.102385975,-0.038282502,-0.020905754,0.077525936,-0.105020575,0.009615509,0.1174328,0.033354342,0.10843642,0.018101618,0.024189046,0.06859955,-0.047845114,-0.03944598,0.040596537,-0.014345859,-0.030312551,-0.042031974,0.055886928,-0.04148399,0.011025113,-0.009671827,0.025496038,-0.009507753,0.0647859,-0.10580587,-0.015986446,-0.05023857,-0.02335769,-0.031434227,0.011279842,0.06546163,0.05781113,0.0035835034,-0.016471751,-0.049339022,-0.008334669,0.08206171,-0.053955622,0.026570199,-0.012461566,-0.021141572,-0.06036175,-0.04552483,0.017028894,-0.015344941,-0.036530558,0.08281387,0.03107866,0.0012696943,-0.048013326,-0.023157828,-0.05784539,0.047698665,-2.3702945e-33,0.083303586,-0.11178574,0.049109105,-0.012103921,0.020873701,0.059165776,-0.07450481,-0.13160168,0.016763564,0.01986416,0.017315678,0.01692835,0.04054459,-0.04751554,0.0010305821,0.057291552,0.011090146,0.10028801,0.012066229,-0.070454456,-0.11005159,0.066261575,0.009265468,0.058135875,0.039252773,0.051440097,-0.07398107,-0.0017329054,0.067513786,0.017411139,0.034738466,-0.051782086,-0.059413638,-0.08130438,0.040664412,0.05918781,-0.0810553,0.008924841,0.022633342,0.061214585,-0.05304954,-0.018535372,0.04443693,0.099435784,0.0065070605,0.037254777,-0.03213137,-0.019053422,0.006438564,0.024197625,0.03896433,-0.06367916,-0.043124627,0.021744767,0.05320711,0.024429929,0.11863981,0.08359868,-0.019620027,-0.04459564,0.044965077,-0.02876983,0.0070004524,-0.04626232,0.021167539,0.007953142,-0.009272888,0.099021494,0.07154427,0.033255897,0.03132225,0.01056369,0.09934802,-0.020149002,-0.0067554996,-0.0001704133,-0.03696808,-0.018296901,0.014748902,-0.038298458,-0.04391766,0.049752254,-0.017182488,0.020212859,0.02409496,-0.0449293,0.061886106,0.0023741734,-0.013091599,0.004209296,-0.030919738,-0.038394187,-0.02953226,0.044383287,0.08442916,-3.0427152e-08,0.034028485,0.005019112,-0.0038973303,-0.0934259,-0.026223369,-0.03743851,0.013288401,-0.062006947,0.047842182,-0.04903277,0.03731233,0.08283994,0.07579188,-0.012120545,0.10085851,-0.07392247,0.08787014,-0.0027440523,-0.04788328,0.03053607,-0.18240872,-0.036524132,-0.11974325,-0.00011561523,-0.02431886,-0.09135797,0.06146657,0.006208191,0.06526804,0.032749515,0.039581873,0.021133233,-0.047176797,-0.05591455,-0.09260986,0.078747496,0.0012019814,0.023396652,0.01431328,0.0070699356,-0.03777986,-0.011884921,-0.039808083,0.016694004,-0.04507334,-0.0048482157,-0.017212413,0.023242947,-0.051342364,0.0621182,-0.05354271,-0.08688423,0.034788623,-0.03752244,-0.07032572,0.08276635,0.08593986,0.02972062,0.071965136,-0.026653515,-0.05968079,0.06569469,0.1460182,-0.030312411 +1.14.99.59,A cytochrome P-450 (heme-thiolate) protein isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin.,384,1.0,-0.04814252,0.004573864,-0.06711129,-0.038145546,0.00088354945,0.083759226,-0.007656221,0.04788805,0.03208255,0.0125311045,-0.017140936,-0.010638879,-0.047080033,0.012264133,-0.01837299,0.06666078,-0.012313836,-0.011992734,-0.011227589,-0.049256008,0.0026676701,0.067146316,0.051672205,0.04951693,-0.012567511,0.012057502,0.07976082,0.03718847,-0.024663048,-0.025137994,0.0062153786,-0.0067966087,0.003243716,-0.030077683,0.05313649,0.103269555,-0.11740466,-0.012132296,0.053642906,-0.023702582,0.05022958,-0.07240201,-0.086318105,0.086217925,-0.12095255,0.018940955,-0.023178522,0.04207509,0.05754204,-0.05844123,-0.016041355,-0.045646705,0.023979733,0.05512273,-0.0020580804,0.052324962,0.037400622,0.02292045,0.012874908,0.008837484,-0.043305136,0.04091253,0.009958752,0.009367453,-0.006544612,0.023514556,0.0010222384,-0.053460002,-0.001033848,-0.09426447,-0.0225491,-0.065597534,0.007882696,0.01204679,-0.037223317,0.0743776,-0.08725188,-0.031712234,-0.02835725,0.014121698,0.014000176,0.01932788,0.06800711,0.07192746,0.02462493,-0.017144151,-0.03782762,0.082943454,-0.084456995,-0.019249849,0.004588196,0.018939406,0.01833664,0.0065258355,-0.08444832,0.012580022,0.031626455,0.07827373,0.024972882,-0.012110957,0.05862987,0.03494795,-0.010788213,-0.082913965,-0.045648336,-0.016520657,0.077806406,0.0063944375,0.09089616,-0.08505604,-0.09406578,-0.045576558,0.0036521384,-0.04899503,-0.020450555,-0.014191141,0.08576488,0.06902737,-0.027291708,-0.036829934,0.0037719999,0.030305695,0.03296089,-0.041924614,-0.05115268,0.014670179,-0.14930716,1.6011719e-33,0.10022647,-0.0033255946,0.02599873,0.020728426,0.008457472,0.035730492,0.017700592,-0.044250418,0.005859014,-0.021742731,-0.072544225,-0.09934945,-0.071004525,0.047800954,-0.040156722,0.017590955,-0.04688971,-0.013942531,0.050204635,0.004207439,-0.05857693,0.022124112,-0.058708362,0.059082404,0.013017844,0.097260326,-0.034555178,-0.0069999075,-0.007388421,0.021817008,-0.04787152,-0.035219308,-0.13653247,-0.047686823,0.01747863,-0.049472395,0.03794237,0.022730622,-0.091968805,-0.019090764,-0.02899764,-0.014105926,0.026148463,-0.07541765,0.0067059835,0.013448702,-0.11283682,-0.005635396,0.010644858,0.04002149,0.030410185,-0.071503624,0.112799905,0.023018751,-0.06337455,-0.07476603,0.020198746,0.026324581,0.014948525,0.026026564,0.047134265,0.102028884,-0.009924004,0.0387289,0.06917153,-0.024512015,-0.022623027,-0.049354743,-0.030677522,0.08188277,-0.023625942,0.07664272,-0.0016045808,-0.0840641,0.03058457,-0.07902519,-0.07766332,-0.009043482,0.01555091,0.0039417483,0.05589142,-0.06715972,0.018566387,-0.014762176,-0.031144483,-0.034043714,0.06486129,-0.018647633,-0.059518132,0.046444163,-0.0058150063,-0.06761867,0.03232198,0.021674287,-0.055983916,-2.4746463e-33,0.09790546,-0.025970034,0.065403365,-0.03629408,-0.015354478,0.110736005,-0.024213353,-0.042562075,-0.06952795,-0.057379894,0.11871752,-0.024662813,0.06329513,0.03586231,0.012840164,0.021348296,-0.064477526,0.055102617,0.010722909,0.013951826,-0.031178214,-0.026151536,-0.012701018,-0.03450254,0.049075905,0.0015817289,0.024673762,0.0552935,0.045417324,0.026277209,-0.059183612,0.13814203,-0.06520073,-0.0684953,-0.027344113,0.033767633,0.0141052995,-0.015301285,0.014438535,-0.03841436,-0.0032827696,0.053537697,0.02231872,0.033171285,-0.018960841,0.100321315,0.022897232,-0.04216405,-0.026875965,-0.0049029887,0.02561941,0.0066749016,-0.017525703,0.019265762,-0.028299423,-0.025430342,-0.0666301,0.016778769,-0.02501576,-0.060977798,-0.06557533,0.022665467,-0.031728454,0.09143014,0.027204288,0.091210805,-0.014616952,0.0714308,0.059539154,-0.009395455,0.049642544,0.03742381,0.10177514,0.11475774,0.017733902,-0.035311755,-0.026172994,0.0143961,0.07397332,0.0648496,0.051116705,0.023993252,-0.036078926,-0.06878074,0.0012990962,-0.08506346,0.018783271,0.078874536,-0.08036199,-0.047524188,-0.042903725,0.108293556,-0.08163466,0.08160914,0.0774826,-2.7874535e-08,0.050243106,-0.045762666,0.005320985,-0.059038084,0.071026795,0.0038930401,0.045666628,0.052818418,-0.013208869,0.0042912522,0.025559971,-0.005533487,4.6853813e-05,0.06540535,0.015704311,-0.031666387,0.0077037793,0.042377993,0.06897896,-0.0098264655,-0.036256917,0.011014488,0.01900396,0.027502667,0.0002903589,-0.06335688,0.0042077946,-0.045523047,0.037360646,0.009741146,0.025722243,0.069828816,-0.08113628,-0.033323213,0.026527328,-0.01753223,-0.12811899,-0.054816447,0.012021714,-0.011528713,-0.021973016,-0.046484448,-0.09662399,-0.021306252,0.026177777,-0.10187174,0.038045213,0.037564915,-0.057705846,-0.059182744,0.008904396,0.06314236,0.010375494,-0.048701,-0.062279228,0.01422013,0.092159204,0.0008707158,-0.08933957,-0.13564156,-0.025657933,0.009249721,0.088771164,-0.031286728 +2.1.1.345,"Isolated from the fungus Psilocybe cubensis. The product, psilocybin, is a psychoactive compound.",384,1.0,-0.00027600615,-0.041071348,-0.12009865,-0.0071906415,0.0113743255,0.06189773,0.014083578,0.0046375715,0.029413456,-0.010167448,0.041767307,-0.0056594196,-0.044990193,0.0142064,-0.04228104,0.1049715,0.010662655,-0.017817168,-0.0010972143,0.018988647,0.035113364,0.08997312,0.07528361,0.055557877,0.010102492,0.05605614,0.053070575,-0.011967129,0.039738815,-0.05681141,0.04414112,0.025491063,0.013720029,-0.035326187,0.08946095,0.07634031,-0.1071281,0.025302332,0.055597045,0.02659733,0.0019452588,-0.068476826,-0.017793454,0.024797047,-0.109699,0.04337381,-0.059528336,0.05106401,0.074025616,-0.050261237,-0.032879714,-0.0562004,0.031632446,0.0891673,0.010360867,0.041704,-0.013629646,0.0043569375,-0.0049585477,0.04240174,0.027745023,0.014499094,0.002298167,0.020450948,-0.016327878,0.06510311,-0.0023760626,-0.052742552,0.05604236,-0.099483915,0.010949786,-0.043968655,0.026893055,0.030414065,0.0030433384,0.035549186,-0.063089065,-0.06119275,0.029565392,0.0045602894,-0.008150386,0.045249883,0.07735426,0.042110927,0.019289589,0.0038408989,-0.04480223,0.087354794,-0.046883117,-0.0009376535,-0.004563395,0.019860864,0.022125844,-0.012056066,-0.05711468,-0.012598586,0.04204893,0.08947038,0.0494484,0.015984423,0.031736266,-0.014577014,-0.00021931069,-0.12023185,-0.06749523,-0.017431276,0.08740209,-0.043757804,0.10353015,-0.035380304,-0.10640296,-0.020180395,-0.026504915,-0.045315243,-0.027332604,-0.061740737,0.14478421,0.09160135,-0.021599934,-0.029206632,0.03027521,0.028716335,0.047837228,-0.049222898,-0.010440225,0.016836073,-0.13771832,-1.2100232e-33,0.06702179,-0.008285867,0.027961759,0.0007382018,0.03124878,0.059699994,0.046474967,-0.07532988,-0.034459077,-0.055394307,-0.07272785,-0.06773146,-0.07246973,0.09608495,0.011164619,0.0110879205,-0.020709148,-0.05233036,0.09959228,-0.035266943,-0.0047386405,0.090058096,-0.08490422,0.076167114,-0.027999753,0.011166416,-0.036636382,0.0114262225,0.0013905878,0.030065175,0.004374967,-0.0030644198,-0.15900105,-0.03294392,-0.008273581,0.014852828,-0.031212855,-0.0050315456,-0.06570094,0.003885867,0.012016059,0.01988578,0.045220792,-0.037315622,0.0017276006,0.010301838,-0.07310674,0.008231994,0.053994663,-2.4946818e-05,0.0029741684,-0.022439916,0.051380828,-0.0517069,-0.06816005,-0.07679882,-0.0059284735,0.015735958,0.045008298,0.023217522,-0.024272531,0.13454308,-0.006010565,0.02362082,0.046113487,-0.057276487,-0.039121494,-0.041979592,-0.037360888,-0.0093571,-0.0011433556,0.06204877,0.0017345195,-0.07166768,0.0021216143,-0.07936929,-0.08084316,-0.069656074,-0.017951997,-0.038972676,-0.0008082775,-0.064511724,0.04960384,0.029636214,-0.095840454,-0.0026515403,-0.00922764,-0.018186118,-0.09165569,0.046482053,-0.043510824,-0.04418566,-0.027124055,0.0026825408,-0.04045391,-9.2365984e-35,0.09364952,-0.023767013,0.08071088,-0.008096785,0.01750822,0.11055628,-0.03085511,-0.030928336,-0.025681486,-0.03280473,0.05890685,0.009139119,0.096626215,0.0149146635,0.02057739,0.075357646,-0.022449601,0.0885617,0.017469881,-0.03335663,-0.024426734,0.033924893,-0.056911845,-0.041053493,0.025410991,-0.009467495,0.024082458,0.031552844,0.03736755,0.034031596,-0.023175707,0.081252135,-0.054621264,-0.103,-0.038120095,0.031146958,-0.05361758,-0.10409084,-0.029963635,-0.09254439,-0.006158801,0.027376238,0.024272203,0.047544967,0.011742884,0.06985765,0.0682611,-0.02185358,-0.027502289,0.038127407,-0.0024539821,0.030969677,0.0013908363,-0.008587907,0.0006375318,-0.017617583,-0.074125685,-0.00012497646,-0.03738385,-0.056536566,-0.043703444,0.043787256,-0.04465896,0.037959337,0.07970199,0.106459,0.023620239,0.07017092,0.033742364,-0.05623287,0.08447633,0.061362803,0.059128474,0.09317093,-0.0033233892,-0.030365527,-0.05099214,0.011588983,0.014338365,0.04455274,0.08906187,-0.049953718,0.014093843,-0.040742293,-0.0019504648,-0.055246677,0.05992935,0.027848033,-0.113214105,-0.00967994,-0.04444097,0.067612045,-0.14142758,0.08261271,0.0910065,-2.0905828e-08,0.07178502,-0.054066125,0.0002935934,-0.08883658,0.04583482,0.01814274,0.03806023,0.06561873,-0.041401003,0.014670723,0.0004193725,-0.017748915,0.029688329,0.08014317,0.020236373,-0.042583052,0.021811334,0.036408376,0.014558546,-0.029847782,-0.0519879,-0.0028255007,0.04849327,0.008014067,-0.08665188,-0.03176837,0.020785399,-0.040170655,0.033186078,-0.004686587,0.030333128,0.06508295,-0.052567173,-0.04607029,-0.035265695,0.0053354413,-0.08155041,-0.034646545,0.022557795,0.023060504,-0.007168217,-0.025559565,-0.042493325,0.026211768,-0.005145776,-0.10756229,-0.019994298,0.014316756,-0.040971335,-0.043623712,0.042947512,0.073171355,-0.0025143423,-0.0024684921,-0.041109454,0.00471843,0.036948256,-0.017696247,-0.07878213,-0.10004174,-0.06277177,-0.008421438,0.062025465,0.028277483 +2.1.3.15,"The enzyme catalyses the transfer of a carboxyl group carried on a biotinylated biotin carboxyl carrier protein (BCCP) to acetyl-CoA, forming malonyl-CoA. In some organisms this activity is part of a multi-domain polypeptide that includes the carrier protein and EC 6.3.4.14, biotin carboxylase (see EC 6.4.1.2, acetyl-CoA carboxylase). Some enzymes can also carboxylate propanonyl-CoA and butanoyl-CoA (cf. EC 6.4.1.3, propionyl-CoA carboxylase).",384,1.0,-0.079351686,-0.049697448,-0.015246,0.0127336895,0.04674851,0.10124944,-0.07672482,0.028181853,0.053681083,-0.07799142,-0.010830577,-0.08077765,-0.11505911,0.016482884,-0.054834276,-0.0045244577,-0.07780816,0.05425376,0.024491196,0.011959089,0.05369703,0.017897213,-0.029005267,0.047917806,0.008834422,-0.027596068,0.008145161,0.0073734084,0.03829238,-0.07229727,-0.022674534,-0.010224766,0.0023475369,0.06859319,0.042850778,0.08984249,-0.01580626,-0.09191372,0.046548463,-0.026285103,0.07123798,-0.052391008,-0.028401274,-0.00841926,-0.017464325,-0.08085793,-0.052715044,-0.033049114,0.060245212,-0.07389854,-0.021916436,0.006231078,-0.06814196,0.044242837,-0.0261818,-0.00059017644,0.016251368,-0.037476245,0.033436038,-0.0018972664,0.04504893,0.043746598,0.00069320167,-0.0061733844,0.004270735,-0.087965995,-0.020886105,0.04903105,0.03360135,-0.026634635,-0.054074913,-0.05860136,-0.037660927,0.0810925,0.05232807,0.0017964818,-0.072409876,-0.037116423,9.081746e-05,0.016656611,0.022381723,0.01948492,0.008499963,0.07116838,-0.012433035,-0.034617685,0.010292132,0.04047039,-0.05720664,0.016398022,0.04564204,-0.028344741,0.07548991,-0.0361769,-0.06761241,0.009714416,-0.0150421895,-0.052870702,0.05378352,-0.03145507,-0.050863568,0.054131392,-0.04529611,-0.07903382,-0.034750838,-0.00366843,-0.012313578,0.093513764,0.11587669,-0.01287127,-0.03322694,-0.0017601569,0.035909757,-0.018885586,-0.054846797,0.07792344,-0.12775992,-0.043195415,0.033489455,0.04290384,0.0031069522,-0.055245366,0.062558465,0.0460714,0.035019502,0.030210268,-0.06793753,1.3236406e-33,0.117290266,-0.012766046,0.023263795,0.05840269,-0.01926101,-0.018910443,-0.04462539,0.019945135,-0.026720513,-0.0019107395,-0.043907233,-0.062401216,0.016173597,0.017901592,0.028414344,-0.055051085,-0.09745206,-0.045947056,0.07487546,0.07215932,0.012954842,0.0724901,-0.05042324,0.062406536,0.04627299,-0.0040099486,-0.09739341,0.06683167,0.06945286,0.026219962,-0.00452765,-0.040428225,-0.062744915,0.045007795,0.051884968,-0.02317712,0.009559941,-0.06790501,0.038763877,0.12569256,0.098386586,-0.05303026,-0.039453324,-0.056439407,0.057517745,-0.023327202,-0.06271174,0.07708528,0.011730153,0.047586687,0.03561638,-0.060010497,0.029840063,-0.043844808,-0.042942643,0.061637938,-0.11683624,-0.021442257,0.008450418,0.039062653,0.04364015,0.044493824,-0.018701619,-0.01848451,0.036901902,0.030145036,-0.07781033,-0.026884377,-0.052131344,0.063892424,-0.03256154,0.019319413,0.04034523,0.0045449473,0.06320705,-0.02125974,-0.09578327,0.06214424,0.031709567,0.018993441,-0.02516774,0.02581643,0.0019988357,-0.013450455,-0.027332066,0.015770063,-0.019289026,-0.017700294,-0.04846719,0.009941022,0.046918362,-0.094430305,0.00095988816,0.055106025,-0.06899835,-3.424991e-33,0.11990751,-0.13149506,0.034841295,-0.07771242,-0.052473854,0.05876575,0.09026279,-0.03955129,0.008537794,0.059896648,0.045193985,0.0076937065,0.05911785,-0.013054415,0.022092791,0.022202065,-0.06085788,-0.036537945,-0.048442103,-0.012124132,-0.053583298,-0.0054926546,0.033174925,0.06479945,0.036970112,0.0015270176,-0.08710879,0.06700213,0.046859577,0.021562848,0.02418948,-0.0098371245,-0.026237935,-0.017567702,-0.08028409,0.055944197,-0.05840345,0.023107382,0.0036048396,0.0013172418,-0.0534084,-0.018292887,-0.071963154,-5.562185e-05,0.11354407,-0.0058601047,-0.055189475,-0.010823621,0.06438614,-0.0075041302,0.03315728,0.055404022,-0.0041183014,-0.023756454,-0.087343946,0.10770952,0.02785604,-0.0073609464,0.08689639,-0.025247408,-0.0059531694,-0.038701955,0.024355171,-0.0064485827,0.03473934,0.0881948,-0.031706784,0.04512873,0.07752319,-0.080695584,0.07622621,0.006066897,0.09416684,0.04759025,-0.00818723,-0.032150358,-0.038794417,-0.055368155,-0.02532354,-0.009731244,-0.033292122,0.0025447963,-0.012124943,-0.04217405,-0.076414414,-0.019870613,0.060111966,0.058019202,-0.016810492,0.018523408,-0.06397583,-0.0070145847,0.033663895,0.037915226,-0.0005868072,-4.4976687e-08,0.064523846,-0.037034277,0.046915434,-0.04307322,0.011508404,0.015424354,-0.01586329,-0.048737198,0.020824753,-0.0076152384,-0.09471503,0.085842304,-0.06353079,0.071180366,0.017750207,0.012541902,-0.0075790803,0.016686026,-0.011353484,-0.054355975,-0.08952484,0.02320276,-0.025337098,0.07144737,-0.03315716,-0.06858176,0.061675433,0.08049789,0.034424778,0.027866704,-0.027257495,0.036494438,-0.006100695,0.020447353,-0.022858694,0.023340447,-0.06609025,-0.052877672,-0.023906661,0.08659235,0.0647348,-0.042071007,-0.038946517,-0.023624005,0.08556502,-0.015578213,0.013299896,0.05182344,0.027233807,-0.0059461454,0.045701537,-0.000664014,-0.13113403,0.021605594,-0.0040345397,-0.030070921,-0.0349482,-0.093394436,0.043058734,-0.052668083,-0.07305298,0.026062826,0.192485,-0.01661927 +2.3.2.31,"RBR-type E3 ubiquitin transferases have two RING fingers separated by an internal motif (IBR, for In Between RING). The enzyme interacts with the CRL (Cullin-RING ubiquitin Ligase) complexes formed by certain RING-type E3 ubiquitin transferase (see EC 2.3.2.27), which include a neddylated cullin scaffold protein and a substrate recognition module. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue in the RING2 domain, followed by the transfer of the ubiquitin from RING2 to the substrate [4]. Once the substrate has been ubiquitylated by the RBR-type ligase, it can be ubiqutylated further using ubiquitin carried directly on E2 enzymes, in a reaction catalysed by EC 2.3.2.27. Activity of the RBR-type enzyme is dependent on neddylation of the cullin protein in the CRL complex [2,4]. cf. EC 2.3.2.26, HECT-type E3 ubiquitin transferase, EC 2.3.2.27, RING-type E3 ubiquitin transferase, and EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase.",384,1.0,-0.10792133,-0.08797368,-0.08437331,-0.014991037,0.07500606,0.0034076096,-0.01961599,0.040340476,0.05698146,-0.11392597,-0.0059717083,-0.04782872,0.03035586,-0.005803529,-0.047988206,-0.035992302,-0.06858474,-7.845712e-05,-0.051421005,-0.0953994,0.06634654,0.009776385,-0.023354603,0.0031888164,-0.02260288,-0.028785544,0.0708011,0.01773912,0.022845788,-0.11965852,0.019209377,-0.039435424,0.009897685,-0.045420162,-0.0070596514,0.089126244,-0.085785605,-0.07352996,-0.0675221,-0.05136759,0.104705855,-0.017394843,0.026791243,-0.0049611605,0.019863015,0.022553723,0.01037424,0.0075987857,0.02782119,0.0012694605,0.015976548,0.008099087,0.025474321,0.08029786,0.049541585,0.06548977,-0.045320515,-0.00371831,0.031423815,0.040239163,0.03874482,0.021543479,0.026213605,-0.06265665,-0.03251771,-0.06077079,0.0573286,-0.057707656,0.016009701,-0.039447036,-0.041084696,-0.004651065,-0.10095482,0.003375377,0.013436107,0.05528447,-0.06938916,0.0075778705,-0.0500828,0.005585123,-0.0077428794,-0.011737277,0.14081419,0.004425455,0.039039884,0.046040926,-0.02231919,-0.052543238,-0.0085607,0.05208806,0.047428813,-0.009361873,-0.030499442,0.02995207,-0.027467405,0.013414361,0.018447846,0.07899396,-0.009343465,0.004791591,-0.0029828318,0.07853238,-0.02492487,-0.062140957,0.015146153,0.014557551,0.010043326,0.11386987,-0.0033519315,-0.007835194,0.005317438,0.025294626,0.056265008,-0.052743185,2.6587151e-05,0.09465031,-0.03869148,-0.048179146,0.09800505,0.032836337,0.037988707,0.030091286,-0.04893534,-0.0071732877,0.026654163,-0.032323834,-0.102559544,5.907582e-33,0.015098069,0.07868603,-0.018408423,0.038324732,-0.12675242,0.01633102,-0.14117868,0.027583377,-0.04719276,-0.0733528,0.018895632,0.04578009,0.041882005,0.024138305,0.0017586494,-0.06986214,0.0007019705,-0.06682022,0.02635662,0.006238342,0.023854729,-0.0133410925,-0.08940427,0.014610586,0.0062363795,0.026807854,0.015470454,0.010356972,0.06355113,-0.0026027507,0.0023949791,0.0074972543,-0.059015058,0.035700914,0.022480184,0.0052245026,0.024294911,0.01298278,-0.01652679,0.061347,0.08296886,-0.023510057,-0.08659396,-0.031933725,0.13573623,-0.09997674,-0.019032203,0.07781563,-0.030715603,-0.0054514706,0.0751705,-0.044882607,0.10790597,-0.04591873,-0.018397558,-0.0136376405,-0.0026702262,-0.014064913,0.027527656,0.040885497,-0.014377444,-0.013354328,-0.06513738,0.08000103,0.05000717,0.1194499,-0.08386769,-0.06787528,-0.04005666,0.0047881245,-0.056796357,0.04270384,0.09648568,0.025000416,0.016755126,-0.03568118,-0.12189471,-0.0018031911,0.062672265,0.06611903,-0.050403632,0.020010745,-0.032030277,0.008907279,-0.05600929,-0.07252802,-0.012682579,-0.03714169,0.020072129,0.0042883926,0.116814665,-0.073899746,-0.040630456,0.069340035,0.019540135,-5.647904e-33,0.11876001,-0.058115277,0.07850865,0.022512747,0.010510278,0.047794815,0.076049305,-0.026146581,0.0668424,-0.073589884,0.09838737,-0.044884864,0.0021285622,0.010578819,0.04537038,-0.03228387,-0.056718696,0.06825933,-0.023658318,0.031034218,0.0048950487,-0.008273703,0.0040930747,0.056182697,-0.049496774,0.048954513,-0.02240987,0.03401245,0.007863915,0.034979023,-0.06314056,-0.059763722,-0.055435855,0.07655882,-0.10457615,0.054870624,-0.026716674,0.017855236,0.089617044,-0.03440113,0.0570688,0.0149989175,-0.048758738,0.008509501,0.041376684,0.095811814,-0.054600865,0.07446482,-0.041248694,-0.08219059,0.02186551,0.062227625,-0.06766557,-0.031010004,-0.03428127,0.04458956,0.094160266,-0.062030666,0.05687474,0.045889616,-0.022926625,0.011911077,0.05455271,0.051307242,-0.035442702,-0.008742229,0.01544265,0.08987146,0.058744352,0.013234866,0.02515343,0.008933348,0.06869906,-0.031220118,0.0348937,0.0012441116,-0.05319717,-0.0108801285,-0.039128534,-0.03835905,-0.037263278,-0.06925161,-0.005184777,-0.07270183,0.02153936,-0.015209248,0.0019689514,0.027994562,0.022786137,-0.047485724,-0.064305924,-0.0114562465,-0.002162448,0.05162457,0.11400717,-4.863874e-08,0.07943816,-0.0119045,0.026690243,-0.052906632,0.05313681,0.045655508,-0.022586789,0.028888397,-0.0013131677,0.015012579,-0.07814543,-0.011284317,-0.0516001,-0.06772574,0.065776706,0.11835743,0.059563506,0.0016992354,0.04452254,-0.06510334,0.0038417706,-0.019921008,-0.031852145,0.030477175,-0.048459627,-0.064857714,0.0108190775,0.083775766,-0.013902838,-0.025112512,0.023308588,0.012138653,0.00916225,-0.005722563,-0.035589147,0.015337778,-0.0011157714,-0.05908697,-0.011376258,0.009676082,0.013970357,-0.021877028,-0.12327273,-0.06725873,0.017107122,0.0037907753,0.05805033,0.009394589,-0.040192317,-0.041005652,0.0073344884,-0.059120126,-0.017565373,-0.049621858,-0.03963093,0.05902457,-0.022847012,-0.07835466,0.043454546,-0.06128184,-0.06374962,0.014967491,0.018181657,-0.027319383 +2.3.2.32,"Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form a complex with a cullin scaffold protein and a substrate recognition module, which is named CRL for Cullin-RING-Ligase. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. The transfer of NEDD8 from a NEDD8-specific E2 enzyme onto the cullin protein is a secondary function of the RING-type E3 ubiquitin transferase in the CRL complex. The process requires auxiliary factors that belong to the DCN1 (defective in cullin neddylation 1) family.",384,1.0,-0.11383926,-0.03909572,-0.026128769,-0.054997485,0.10580394,0.0063831187,-0.014948462,0.042485174,0.020441977,-0.09824161,0.010281541,-0.049529977,0.011105727,0.04025263,-0.046632648,-0.034032963,-0.078937896,0.0285892,-0.04785447,-0.10161583,0.04840066,0.055902928,0.012591836,-0.03424072,-0.009452508,-0.031270184,0.074197434,0.02880887,0.049380466,-0.11636525,0.025506228,-0.010333295,-0.031525362,-0.028077845,0.008843347,0.10770958,-0.051512524,-0.07719202,-0.07329891,-0.059524953,0.12737064,-0.014423247,0.056123853,-0.028194245,0.004321932,0.014257726,0.013945956,0.0188661,0.047459457,0.006024248,0.032258276,-0.03140436,0.014273305,0.07712682,0.047103077,0.099483885,-0.046730306,-0.03032795,-0.0016189482,-0.0014531454,0.03961193,0.029303085,0.024443557,-0.02849667,0.008572849,-0.07178967,0.035084043,-0.05355186,-0.028937476,-0.014264994,-0.017828887,0.0035868706,-0.063469335,0.05774315,0.01777745,0.0707565,-0.07555796,-0.030289492,0.0009279208,-0.0167977,-0.02878477,-0.010709145,0.13413572,-0.00834954,0.07254197,0.039788254,-0.0531348,-0.062861,0.006507783,0.05093415,0.018885897,-0.014666475,-0.014584477,0.044377778,-0.03196685,0.0068494882,0.03073805,0.049187165,-0.054133136,0.040368475,-0.016602071,0.10510819,-0.006443829,0.0071971705,-0.0052382415,0.0033106757,0.020593746,0.079714134,-0.065923035,-0.03388216,-0.026662843,-0.007131149,0.062427904,-0.060027145,0.010970217,0.07203474,-0.05898531,-0.037118915,0.060334083,-0.01152725,-0.009008754,0.044402175,-0.05593466,0.015331246,-0.02681365,0.014151067,-0.06768025,3.9149417e-33,0.008659603,0.060042683,-0.049885143,0.02850559,-0.10294088,-0.01969902,-0.13626087,0.015312009,-0.027495142,-0.07435379,-0.032636765,0.013017016,0.024277905,0.050301686,-0.018381353,-0.06224988,0.033344053,-0.01888809,0.016363157,0.032586414,0.021870764,-0.0023413335,-0.04666402,-0.020765798,0.016206583,0.009103278,0.016853506,0.036665823,0.09773292,0.014417955,-0.04157413,-0.019664075,-0.034388162,0.011487873,0.026758354,0.0008237943,0.031607755,-0.011129104,0.0071001123,0.050993357,0.080649965,-0.010198348,-0.091984615,-0.050013077,0.049540915,-0.07274404,0.008847735,0.06501994,-0.036769804,-0.003467236,0.11150855,-0.047363624,0.043016825,-0.08194347,-0.03784533,-0.029522294,-0.02603083,0.011270069,0.050333023,0.0033257776,-0.02257269,-0.01754792,-0.040232055,0.08757786,0.031829927,0.09170906,-0.08757801,-0.1144173,-0.033376444,0.026829876,-0.05594659,0.0066566197,0.022429192,0.03028223,0.067320764,-0.07481785,-0.114936076,-0.034793455,0.06805608,0.070192285,-0.044149954,0.025174849,-0.07002096,-0.045746185,-0.039626803,-0.101327226,-0.011527753,-0.025093898,0.021603238,-0.0031467765,0.107566364,-0.044654567,0.015236812,0.087876566,0.04737618,-4.3452696e-33,0.058795117,-0.06665356,0.07748487,0.0065040877,-0.011077861,0.07921083,0.075054705,-0.041023906,0.07057357,-0.04646839,0.079685934,-0.07086591,-0.005611004,-0.022994429,0.02243599,-0.033170603,-0.07532355,0.05734775,0.029276194,0.0040192036,0.0069863736,0.042196296,-0.0035362905,0.08614211,-0.042020224,0.051658735,-0.09144774,0.057919987,-0.018321512,0.033502966,-0.056262698,-0.05133779,-0.047589112,0.12283029,-0.09228211,0.06014487,0.014827352,0.032164574,0.047235776,-0.05533116,0.0951666,0.012876512,-0.05269907,0.06373826,-0.0016976448,0.06482624,0.0068415194,0.031925328,-0.007589978,-0.038959704,0.015161119,0.06471272,-0.06641298,-0.047694206,-0.047016025,0.1069091,0.12647526,-0.039121386,0.052402582,0.02927971,-0.010939258,-0.0016455258,0.04465719,0.031691145,0.03232918,0.00030519787,-0.007233452,0.11674941,0.083150335,-0.0016727296,0.029923093,0.050678898,0.080673166,-0.027435599,0.024103438,-0.013805729,-0.064774714,0.012487934,-0.0153250145,-0.04307424,-0.054740198,-0.053154208,0.02308313,-0.024644377,0.0038847895,-0.0020820915,0.036803853,-0.008317139,0.034590907,-0.03954186,-0.028826222,-0.0408033,-0.029114224,0.0968869,0.0871214,-4.1261053e-08,0.0596438,-0.05132279,0.022574548,-0.078975804,0.027435763,-0.0060070376,-0.02131851,0.021673359,0.040666297,-0.018601287,-0.093946666,0.043260664,-0.041370697,-0.051702205,0.043831766,0.08367283,0.012935332,0.030938907,0.012512032,-0.09171547,0.0337709,-0.02828204,-0.018599078,0.04450545,-0.040611323,-0.054994326,0.019143313,0.14145179,-0.009588337,-0.06112425,-0.018523773,-0.0044318214,-0.022827258,0.0036609482,-0.025452757,0.035985883,0.042069923,-0.07388781,-0.049064722,-0.008704146,0.019125123,0.01338137,-0.07855317,-0.07297898,0.010284346,-0.0069209663,0.0668858,-0.005210936,-0.039824113,-0.013860348,0.0065789726,-0.040292233,-0.017347952,-0.054741263,-0.060198072,0.00032276195,-0.049695782,-0.09118544,-0.010290067,-0.056936942,-0.038002647,0.044295467,0.081626795,-0.054505736 +2.4.1.348,"The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a.",384,1.0,-0.030618671,-0.06686022,-0.060537193,0.018253965,0.034145877,0.03475554,-0.010871351,0.078990296,0.090996616,-0.063892305,0.020860478,0.039399896,-0.10198868,0.005780736,-0.04992404,0.013859446,-0.041716672,0.015826643,-0.031173345,-0.10098241,0.12293801,-0.036928628,0.008030897,-0.05619238,0.03247724,-0.06373908,0.031149106,-0.035349034,0.0068343566,-0.078201555,-0.028457046,-0.026689067,0.012949021,-0.038003284,0.07009687,0.060666967,0.07348269,-0.10281524,0.099139705,0.010006022,0.07609621,0.02796689,-0.0045279455,-0.009498184,0.00019857366,0.020567788,0.024340488,0.027506012,0.016291315,-0.039612886,-0.032910272,-0.05969319,-0.0675935,-0.0155521175,0.061061516,-0.014097429,0.035204753,-0.13152744,0.018396068,0.047577046,0.027061766,0.024622055,0.068020225,0.034667682,-0.021554744,-0.064222485,0.07098644,-0.0055141533,-0.05101783,-0.027029276,-0.032682355,0.010288221,-0.04346147,0.0025292798,0.018263116,-0.043974508,-0.033370055,0.006896972,-0.015151945,0.053032283,0.05294144,-0.0107654305,-0.025485355,0.087083705,-0.026600188,-0.0156358,0.032038007,0.012197091,0.0686841,0.09179066,-0.061847307,-0.025791626,0.014864173,-0.049951024,-0.045514006,-0.058877062,0.06697548,-0.007944856,0.003564455,-0.027981205,-0.06127728,-0.038818654,0.086387195,-0.03247214,-0.031844854,-0.010298602,0.0390501,0.099259645,0.0049543963,0.010085001,-0.013095508,0.0034965512,0.027894393,-0.00989444,-0.082320586,-0.05400223,0.011835936,-0.07327124,0.0017244326,0.06083587,-0.0049441042,-0.05848166,0.010151573,0.07558497,-0.036700018,0.018697478,-0.098119505,1.1511925e-33,0.058559414,0.013174033,0.01562969,-0.079799995,0.044246245,-0.05594752,-0.008135667,-0.062174886,-0.09821309,-0.0121292295,-0.14504378,-0.13934994,-0.0007600612,0.03303525,0.059927188,0.0049666334,-0.027925221,-0.030844366,-0.0124447225,-0.009474004,-0.020465223,0.031164087,-0.003367482,0.020768188,0.059879214,0.003542235,-0.08008167,-0.019918218,0.0150096025,-0.028878089,0.08701441,-0.045170173,-0.08704601,0.07674569,0.11566542,-0.034577284,-0.015808977,-0.039830264,-0.007921261,0.0026762336,-0.0132056875,0.068501934,0.020550808,-0.024994075,0.065797634,-0.028922835,-0.055026054,0.08946652,0.033786356,0.07983245,-0.0056419587,0.045158867,0.06031608,0.009887645,-0.012554707,-0.051345535,-0.06914421,0.035828944,-0.019897355,0.051951192,0.055210974,0.018320935,-0.017139966,-0.027077125,0.0052699796,0.025895778,-0.014912731,-0.030071639,0.031727597,0.028026806,-0.06914605,-0.069756344,-0.019927066,0.045352727,0.043688737,-0.0027525588,-0.103250206,0.020090027,0.059346776,-0.045179415,0.07379624,-0.008556707,0.028545769,-0.03564097,-0.057732537,0.03819281,0.023449857,0.032739095,-0.042399283,0.09910103,0.09023134,-0.09493167,-0.008999816,0.055755798,0.0076774894,-3.532104e-33,0.047715925,-0.08794749,0.10259636,-0.10019936,-0.11100446,0.0256864,-0.056201585,-0.010797496,-0.007843509,0.047194853,0.013950307,0.04775133,0.06193846,-0.0045608114,-0.010969794,-0.0027572892,-0.030527089,0.14985012,-0.017772138,-0.018721454,0.0007359866,0.0043873796,0.07201154,-0.027099961,0.008759682,-0.015522877,0.027888708,0.08389552,-0.009136215,-0.018529698,-0.017938873,-0.027140448,-0.042137034,-0.012516484,-0.06865235,0.0013512535,0.008210926,-0.0134461,0.10428572,0.0146802245,0.013910699,-0.02117408,-0.0062156282,-0.0046615233,-0.01802847,0.048498984,-0.07752676,0.03517407,-0.033879973,-0.03412942,-0.0007912756,0.009732186,0.011814547,-0.01149609,-0.019664023,0.048820946,0.04262368,0.00454309,-0.019744903,-0.07306667,0.014014147,-0.04350391,0.06553056,0.03370815,0.029735636,0.0015316738,0.0037963437,-0.021582497,0.009103731,-0.012157869,0.007709651,0.02306439,-0.066373535,0.011163478,0.046854362,-0.04536339,-0.12076744,-0.018078314,0.0033947295,0.033449072,-0.061292667,-0.0044636033,0.013315688,-0.027160494,0.047696482,-0.04661664,0.11097906,0.101232,0.06294213,0.030006064,0.029514482,-0.01089444,-0.054970734,0.08372267,0.045149937,-3.2214146e-08,0.02329265,-0.09713737,-0.0005875404,-0.09242703,-0.028786132,0.013577211,0.024054684,0.016353477,-0.004277378,0.046781246,0.048024926,0.10853504,-0.03607096,-0.022351822,0.07256526,-0.02266516,-0.016062666,-0.01106822,0.022858083,0.0025140273,-0.023025135,-0.040022183,-0.044360265,0.08843735,0.030102037,-0.076858,-0.015747236,0.026882982,-0.021254804,-0.0062811603,0.029320901,0.042642035,-0.029858265,-0.0935152,-0.1124465,0.017151799,-0.011146535,-0.040081613,-0.013294817,0.032813147,0.07985706,-0.038002204,-0.044501938,0.010957817,0.096716255,0.0994953,-0.0024726829,0.017243465,-0.06772499,-0.022403555,0.07800807,-0.047446672,-0.040667098,-0.032838687,-0.14862448,-0.09022645,0.009216924,-0.04017315,0.012817767,0.024870252,-0.008805007,0.05873218,0.14376324,-0.078615464 +2.4.1.349,"The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a. It has no activity with N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.4.1.348, N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase).",384,0.99999994,-0.018705826,-0.07478826,-0.0933266,-0.014002304,-0.001993393,0.017089024,-0.03530994,0.058966253,0.10547359,-0.042696953,0.057504524,0.05495073,-0.114041775,0.025704887,-0.076263964,0.0069646006,-0.032562368,0.024942828,-0.04418402,-0.06819086,0.10416181,-0.039750993,-0.003537623,-0.060349274,0.03773164,-0.043487214,0.016245162,-0.044902604,0.010710356,-0.09629573,-0.045439158,-0.028382072,0.035544526,-0.051497772,0.13301793,0.066743515,0.08373476,-0.060119025,0.09659334,-0.0012380215,0.051860716,-5.9635753e-05,0.0103770755,0.014188506,-0.007204774,0.00023691138,-0.05143394,0.051598735,0.046764985,-0.008196801,-0.0021701597,-0.037832636,-0.024904544,0.0013878336,0.049574565,-0.0031143646,0.012055782,-0.12151579,0.00079284294,0.045355976,0.016081136,0.030010253,0.0708901,0.0067940447,-0.03775016,-0.054451868,0.081394374,-0.037215736,-0.022977924,-0.010415597,-0.06156972,0.018899389,-0.018722221,0.015163507,0.03166712,-0.031875923,-0.02043558,-0.0014301225,0.016526364,0.028605774,0.0832902,-0.0015277006,-0.020174006,0.082491145,-0.04807109,-0.016881235,-0.03562563,-0.00041013517,0.085577786,0.0805044,-0.0890794,-0.028883748,0.025948076,-0.08228122,-0.016480284,-0.05077418,0.050693758,0.014589041,-0.018927366,-0.019859707,-0.04001467,-0.026288029,0.049757104,-0.055470224,-0.049265847,0.007712083,0.016288878,0.059230726,0.007950566,-0.009788933,-0.0013716954,0.005910903,0.029118959,-0.042719312,-0.12747866,-0.023258341,0.003871166,-0.09313665,-0.0008629802,0.027823603,-0.025359401,-0.05003615,0.034466796,0.08268389,-0.028071206,0.033510014,-0.044525426,3.407564e-33,0.04707663,0.0140298605,0.03452427,-0.046303023,0.069327116,-0.05303991,-0.0169769,-0.07915287,-0.059119925,0.00484783,-0.1648877,-0.10938138,-0.0045111137,0.040485542,0.078847334,0.07350556,0.00091690844,-0.022057924,-0.024258908,0.007262153,0.015907692,0.0375415,0.008136274,0.0035113893,0.08797009,0.036099695,-0.0825054,-0.0107613765,0.041899454,-0.025936898,0.086727194,-0.039387338,-0.07455235,0.048371796,0.106419444,-0.014381638,-0.037896935,-0.038375124,0.001948013,0.0471378,-0.022310816,0.06773882,-0.009590812,-0.050125375,0.047897156,-0.033951037,-0.0090121655,0.056552082,0.03301224,0.08430112,0.021371266,0.020723943,0.034756668,0.00082872674,-0.006018673,-0.057368852,-0.07185652,0.014810446,0.030573165,0.071489446,0.039076738,0.022485185,-0.01462371,-0.048676077,-0.01747214,0.03727405,-0.031064738,-0.008322167,0.042671546,0.02303989,-0.055375926,-0.06667694,-0.015156414,0.055471595,0.08059453,-0.043425225,-0.08765103,0.05300678,0.083360784,-0.028986381,0.12746918,0.010116959,0.040134862,-0.048504125,-0.06519876,0.06328747,0.0054887584,-0.008806557,-0.027810799,0.08855779,0.042996984,-0.05408958,-0.0792081,0.048099063,0.032627918,-5.426998e-33,0.06354292,-0.11500455,0.07014755,-0.09188409,-0.11330179,0.049105234,-0.037773464,0.014360433,0.036818624,0.048272025,0.037155557,0.048851572,0.025478901,-0.0036655255,0.0048948317,-0.0065986253,-0.05422788,0.13366577,-0.024502376,0.021579849,0.00046306622,0.04904308,0.06561662,-0.0058186394,0.06110681,-0.04576717,0.0010215729,0.0887658,-0.010024459,-0.008555891,-0.0049717147,0.00041289738,-0.045485754,-0.03659105,-0.065857574,-0.02279877,-0.025216246,0.02616868,0.016188368,0.015470035,-0.047701743,0.010298018,0.030237949,-0.02148496,-0.0073169773,0.08893465,-0.088147216,0.033013795,-0.04886627,-0.017653812,0.022188531,-0.023354076,0.012781371,0.043257274,0.03273311,0.041258343,0.022020001,0.03694946,-0.021982089,-0.046061475,-0.011058666,-0.08407889,0.045152217,0.0018147299,0.085942835,0.06864278,-0.007605533,0.0058924165,0.019697683,-0.030802555,-0.008727546,0.00643409,-0.059024293,-0.0069552152,0.05559941,-0.025695233,-0.1415295,-0.03747842,0.015273461,0.009372258,-0.08365871,-0.035522074,0.0067006764,-0.008983458,0.036197897,-0.03487934,0.11425901,0.11926656,0.022438044,0.07464477,0.019900393,-0.004770073,-0.07311856,0.03590433,0.04765417,-4.7815888e-08,0.028496688,-0.06760713,-0.0014981065,-0.097119324,-0.043228,0.0066050906,0.025421327,0.022337036,0.022970734,0.03277495,0.038258433,0.11376179,-0.020757081,-0.023324488,0.019125048,-0.024953838,0.008803708,0.012715555,0.03214949,0.033274684,-0.043343637,-0.008704662,-0.03987736,0.045432083,0.044308648,-0.08655052,0.049799107,0.019746648,-0.034714013,-0.03755742,0.007348583,0.022561453,-0.045474406,-0.10636881,-0.09667202,0.031537987,-0.028812276,-0.06485786,0.0026838393,0.014539138,0.036452144,-0.00061835104,-0.02469248,0.0055111763,0.051515996,0.060294133,-0.0050696908,0.012053313,-0.067630984,-0.021463867,0.053738758,-0.057099983,-0.053136844,-0.062812515,-0.117813915,-0.11637603,0.002461517,-0.056577604,0.008235631,0.02010951,0.027747033,-0.002329359,0.12153288,-0.05347707 +2.4.1.350,Isolated from the plant Siraitia grosvenorii (monk fruit).,384,0.99999994,-0.06337199,-0.00393133,-0.14481787,-0.05265314,0.041205317,0.07330443,0.010422396,-0.027600998,0.020517513,-0.02603558,0.113089025,-0.0449557,-0.005967746,-0.01995733,-0.04937735,0.030565986,0.0062564323,-0.017144298,-0.0049846782,0.026471531,0.035929862,0.05902966,-0.031766377,-0.0007815598,-0.015067947,0.007042438,-0.02251732,0.013973275,0.038350496,-0.09009753,-0.0011502008,0.014409129,0.085971735,0.00038650213,0.024005728,0.061496843,0.023291918,0.030757286,0.10243405,0.030120509,0.03726215,0.04153214,0.060772143,-0.041715425,0.023894457,0.03357355,-0.08087567,0.025108308,0.070806935,-0.06730239,0.0027655289,-0.02610483,-0.004707684,0.0015090205,-0.016117353,0.002845088,0.050212007,-0.04558464,0.009353669,0.070366025,0.0425255,-0.010729012,0.017617678,-0.009519154,-0.056208543,-0.0049673826,-0.10244761,-0.06389491,0.13402104,-0.030462172,0.047565345,-0.044522498,0.006714876,-0.009808609,-0.1140839,0.024839807,0.010068044,-0.015770927,-0.020066071,0.07876598,-0.046378605,0.02140038,0.053748302,0.039602157,0.0024055385,0.016461093,0.03405427,0.02723879,-0.02515603,-0.05001865,-0.02662442,0.035027154,0.0073597045,-0.0414556,-0.034866635,0.013580974,0.036112744,-0.07995208,-0.023383478,0.029707743,0.0105263535,0.0017365995,-0.023655104,-0.10419325,-0.10136259,0.021229306,-0.04774929,-0.051187485,0.06237187,-0.0025479435,-0.053230826,0.04821679,-0.040848732,0.0022356983,-0.052964423,0.0068232715,0.12060362,0.03863563,-0.07142553,-0.00031318926,-0.039619688,0.03298612,0.06772123,-0.047822908,0.018876908,0.017088484,-0.039748233,-2.6665507e-35,0.036382895,-0.040508777,0.011327201,-0.042641602,0.07154415,0.00433557,0.014141504,-0.04993888,0.040992778,-0.060023673,-0.047124512,-0.055061407,-0.08595223,-0.033326875,-0.02023043,0.067232765,0.045316968,-0.023254875,0.08682069,-0.10128886,-0.0019604764,0.06824349,0.006128039,-0.047892418,-0.016111223,-0.013030488,0.07166881,-0.08330847,0.13053283,0.016858606,0.010921165,-0.037473723,-0.029712979,0.0150574315,-0.011520001,0.053262148,-0.07326502,-0.07605559,-0.0020250068,0.07933478,0.026942179,0.010859817,0.104316935,-0.0075983484,-0.024075136,-0.034550056,-0.013212049,0.008401578,0.07869399,-0.01473251,-0.10728195,-0.005323801,0.07536069,0.013101416,-0.0586834,-0.10312954,0.026998382,0.043831956,-0.020815607,-0.0021873412,0.00010188212,0.020714145,-0.020857964,0.031060927,0.025557395,-0.0037813303,-0.14478187,-0.016221156,-0.030160353,0.005565175,0.0036113511,-0.016795617,0.06716095,-0.09770603,-0.00921261,-0.031104226,0.005565882,-0.026292829,-0.01278381,0.034088183,-0.06225301,0.053822108,0.00031714537,0.052883707,-0.05406278,0.0035884797,-5.725159e-05,0.0503147,0.036494862,-0.02188609,-0.008262676,0.0047207843,-0.068828985,-0.016457481,0.0021099013,-7.030818e-34,0.055693757,-0.0012417133,0.04748556,-0.020463126,-0.011339844,0.049426377,-0.083386816,0.07552341,-0.015846098,-0.016558785,-0.057153314,0.015442102,0.042200033,-0.013519319,-0.010494498,0.08170169,0.097674206,0.13503408,-0.084639154,-0.09536702,-0.07279174,0.022928054,0.032854,-0.069483995,0.07019506,-0.007102173,0.04902291,0.035574213,-0.02427211,-0.0012811922,0.050885383,0.022315217,-0.1037707,-0.032448053,-0.040006727,0.036720622,-0.05418127,-0.107241325,-0.0076263556,0.012644051,-0.001452513,0.02729498,0.070929155,0.07812071,0.1264384,0.009123557,-0.0012834235,0.059696585,-0.020537315,0.07420788,0.021388797,-0.020709453,-0.024383308,-0.0023450567,0.0664239,-0.10171478,-0.019709615,0.07161265,-0.05431019,-0.041284487,0.042009074,-0.015366754,-0.15005946,0.01701647,0.02373249,0.15550476,0.033642843,0.053195544,-0.008914443,0.029394578,0.020851528,0.033156585,0.018535016,0.064813286,0.029921433,0.05563614,-0.022923473,-0.056926984,0.0036896828,-0.011068316,0.008920351,-0.023535494,-0.01492771,-0.032823022,0.03861709,-0.045329362,0.003474785,0.022478689,0.02798069,0.0052238237,-0.028436264,0.04935839,-0.10042408,0.010654363,0.0739583,-1.7869192e-08,0.10546562,-0.07026425,-0.01872844,-0.04831307,-0.024765562,0.010840511,0.008266248,0.018375725,0.08172163,0.0007765468,0.002727531,-0.033017542,-0.0009543348,0.014212922,0.03575768,-0.02355608,0.09463033,0.08343186,0.001475586,-0.018881656,-0.09482788,0.012707693,0.01584242,-0.01301997,-0.09448734,-0.032803655,0.03293463,-0.017017405,-0.018054308,0.023595095,0.07540098,0.050380446,-0.045850158,-0.031423714,-0.024334442,0.09790886,0.006964172,0.05993903,0.012927851,-0.014404998,-0.037697837,-0.024422038,-0.07942505,0.018069128,-0.06927927,-0.015496387,-0.034255777,0.036483906,-0.026310379,-0.029536104,0.0072392877,-0.020922888,0.1323955,-0.043924663,-0.12760697,-0.01965875,0.025104702,-0.11111237,0.0056118695,-0.0016644596,-0.044526763,-0.045349665,0.07335087,0.07276706 +2.5.1.142,Isolated from the plant Solanum lycopersicum (tomato).,384,1.0,-0.061449137,0.004394303,-0.14576761,0.0089474395,0.109015055,0.043805618,-0.023073668,0.010086467,-0.005042631,-0.048700076,0.15031898,-0.033215724,0.047542654,-0.008835458,-0.03698365,0.029248267,-0.012037229,-0.012757149,-0.02746926,-0.007975407,-0.036523335,0.13496172,-0.03404225,0.013824316,0.025224421,-0.029822033,-0.03827887,0.012439353,-0.0021439285,-0.07253193,-0.06141434,0.024850082,-0.00016154273,-0.011778335,0.03145354,0.0042752544,-0.04000161,0.018036703,0.11177753,-0.0071429163,0.0047027566,-0.04930676,0.02454056,-0.045598928,0.0105612045,0.073494345,-0.09504334,0.001964213,0.03874648,-0.0132778,-0.022884179,0.008574496,-0.008104315,0.018056909,-0.015510017,-0.03536931,0.00921518,0.04683579,0.01881761,0.091451265,0.02169743,0.022971516,0.02304572,-0.027925808,-0.029286088,-0.025374524,-0.030352153,0.004522604,0.11544806,-0.0496295,0.018278882,-0.08445578,0.015618324,0.0596284,-0.076248005,0.019899657,0.02452085,0.02349873,-0.0054854914,0.069202915,0.05067567,0.011195917,-0.02203265,0.039559826,-0.002869809,-0.025715867,-0.023180217,0.058459695,0.00494794,0.0033652338,-0.0074212486,0.028805923,-0.030731266,-0.021545583,-0.039810088,0.014351712,0.022342488,-0.03781109,-0.054513995,0.027375583,0.027260944,-0.071722,0.02074861,-0.11240345,-0.063766986,-0.01648294,-0.0033134061,-0.09931058,0.026600778,-0.0064100716,0.0006434293,0.061858147,-0.10457988,-0.088340335,0.02318824,-0.017992146,0.07763892,0.02021185,0.001548783,-0.00959234,-0.013234766,0.047425337,0.12592451,-0.029775642,0.0023843753,-0.0036998542,-0.08257913,-8.870206e-34,0.0143994335,0.02982219,0.0047980985,-0.03434269,0.036213998,-0.021297975,0.023656772,0.08318434,-0.05130958,-0.029944759,-0.11106208,-0.06199223,0.0012236398,-0.020596463,-0.041123834,-0.031522587,-0.008290596,-0.03889269,0.028069818,-0.040452998,-0.044626866,0.030670919,-0.035422966,0.015185559,-0.030967155,-0.07175659,-0.006977523,-0.08636811,0.06909377,-0.026845997,0.042362206,-0.035420835,-0.025049224,0.017600527,0.061847698,0.02027307,-0.10324415,-0.054833483,-0.022193797,0.025306646,0.037942417,0.028907606,0.07127806,0.009993284,0.059167035,0.08434462,-0.07245579,0.03612461,0.04604363,-0.053628065,0.021391835,-0.011747775,0.003012512,-0.010723204,-0.039788917,0.009409522,0.015298356,0.04203272,0.00036229554,0.05182187,-0.030372586,0.04608876,-0.042879548,0.0039700335,0.03646432,0.05259593,-0.1587092,-0.015123216,-0.032751005,-0.08630964,0.022135137,-0.09606911,0.0627143,-0.037064653,0.04284385,-0.005409534,0.025960607,0.022177633,-0.051501088,0.0026662927,-0.029304827,0.015860718,0.08216375,0.032357026,-0.060351677,0.056152873,-0.06751667,0.024868703,0.052595105,0.029243156,0.019401519,0.012959755,-0.037199926,-0.026398154,-0.012405317,-4.1205425e-34,0.06453883,0.06246316,0.03444613,0.0006715988,0.03333437,0.030787202,-0.052868135,-0.013936412,0.012266,0.038681548,0.0028058807,-0.01921318,0.09031108,-0.07747401,0.011425547,0.13358608,0.056131564,0.13039877,-0.047242723,0.028837157,-0.121547304,0.040384576,0.010810188,-0.07702847,-0.010152705,-0.020996828,0.04620431,0.0024794082,-0.0031572655,0.00049629546,-0.026408358,-0.036991358,-0.055286527,-0.044506457,0.006583247,0.026579147,-0.073132165,-0.14354284,0.011926208,0.058636162,-0.08058925,0.0681336,-0.004892602,0.08330877,0.07701375,-0.01252667,0.04099892,0.012845264,-0.07012774,0.0671599,0.044142097,-0.02252718,-0.0011458441,-0.02876772,-0.00054262276,-0.03401331,0.017867256,0.077937745,-0.008329985,0.014744098,0.11342256,-0.047107276,-0.08935485,0.0057839425,0.05464944,0.07500751,-0.016811574,0.069126055,-0.065223046,-0.02143938,0.05953841,0.0010479271,0.06010558,0.03869021,0.028532114,0.034333777,-0.033153504,-0.03803428,-0.03904951,0.008028638,0.024503931,-0.07402913,0.026409633,-0.049872555,0.023534259,-0.08604029,0.02751492,-0.011719819,0.00034422474,0.0073346067,-0.016660139,0.040036973,-0.07588171,0.043765318,0.16112559,-1.8372026e-08,0.106259085,-0.061445344,-0.05302544,-0.033429436,0.01859796,-0.013183975,0.015002082,0.031756394,0.033862256,0.059953652,-0.06813858,-0.026060054,-0.0625375,0.0013080955,0.059415266,-0.039937507,0.057722416,0.12762184,-0.016905155,0.06007566,-0.03765556,0.022939142,-0.043834448,-0.06711317,-0.028161,-0.022115797,0.038027026,-0.047708746,0.07028148,-0.036667038,0.046109334,0.019981025,-0.039632753,-0.10377127,-0.06178744,0.06898681,-0.015971215,-0.017595168,0.022026815,0.045841854,-0.06468754,0.01867439,-0.03079356,0.04344268,-0.07191971,-0.019958846,-0.027090164,0.015740316,-0.050352037,-0.050720178,0.060122557,-0.01622506,0.0868412,-0.0530638,-0.0030359577,-0.025162568,0.016303122,0.0035334749,-0.021033682,-0.0043596462,-0.123875566,0.09411415,0.11585329,0.07935101 +2.7.1.222,Also acts on 4-hydroxy-L-tryptophan in vitro. Isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin.,384,1.0,0.03733871,-0.032949932,-0.08607882,-0.02260208,0.0018799393,0.10728831,0.00585543,-0.002956001,0.045826316,0.034276668,0.026164578,-0.009569766,-0.039219387,0.073863536,-0.056203254,0.12701392,0.0006702266,0.0007206605,-0.017948342,0.009103624,0.039364934,0.040001586,0.05007438,0.029531522,-0.027371278,-0.0032991925,0.051000014,-0.032037977,0.018337714,-0.010733576,-0.00020766587,0.026102649,-0.022277765,-0.04198072,0.06450872,0.08613619,-0.08480262,0.04194559,0.089344196,0.029247548,0.0191608,-0.105863705,-0.0498073,0.05076343,-0.09250349,0.03674767,-0.006722207,0.06403293,0.058779646,-0.07718726,-0.052987467,-0.041856587,0.027477214,0.06611957,0.013725192,0.061015543,-0.027113535,0.0306236,0.026783934,0.07441393,-0.017330393,0.03882545,0.03173019,0.008671301,0.028541612,0.015027558,-0.023867866,-0.082099885,0.013918153,-0.07118033,0.005993281,-0.04628573,0.039152488,0.013075118,-0.0022613113,0.03311833,-0.057331212,-0.055722807,-0.030826898,-0.023046914,-0.0036856183,0.023939839,0.048653282,0.07268335,0.029415064,-0.02842262,-0.058721382,0.093410216,-0.029770492,0.0077192774,0.02452859,-0.026281677,-0.021511842,0.027723975,-0.029610718,-0.0053382716,0.015016757,-0.01719357,0.04259825,-0.012054367,0.03318324,-0.030197367,-0.0546946,-0.111874156,-0.011075065,-0.024721535,0.10191111,-0.009097356,0.08140521,-0.051691,-0.07771159,-0.041696154,0.002774213,-0.004841593,-0.06390936,-0.03724783,0.105284475,0.023588995,-0.08911723,-0.051303376,0.05166085,0.030074473,0.048778962,-0.010452124,-0.04272902,0.036995903,-0.10648119,4.0982375e-34,0.11435584,-0.0144918095,0.026378004,0.014109163,0.023941305,0.07356008,0.035097886,-0.09155997,0.020086192,-0.03848361,-0.07189165,-0.12294442,-0.04547081,0.10178785,-0.03787804,0.044031154,-0.094583586,-0.06337084,0.07108875,0.021507094,-0.061412774,0.03555113,-0.084272444,0.04448791,-0.039624132,0.07187848,-0.03327832,0.009778175,0.03042595,0.024249917,-0.018221207,0.0062087793,-0.17364001,-0.009189215,0.007819284,0.0028684027,0.009724052,0.020079423,-0.0668755,-0.004599616,0.0012350559,0.049444627,0.012073347,-0.04523263,0.019358786,0.03608061,-0.042658307,0.049872767,0.0810561,0.01791376,0.0288329,-0.040997546,0.04665407,-0.047557782,-0.0840246,-0.09478278,-0.00678599,-0.0015025837,0.036216598,0.009745049,-0.076750375,0.07427465,-0.010330034,0.023007357,0.021904368,-0.07028065,-0.008546727,-0.08736979,-0.04096397,-0.008644695,-0.033737034,0.039380383,0.008526752,-0.07235953,-0.012975743,-0.091613,-0.04013137,-0.04852835,0.016845783,-0.020435123,0.09745467,-0.07310864,0.050176762,0.0065926537,-0.056058396,-0.016041467,0.02586946,-0.07154233,-0.032635767,0.000550399,-0.0104509685,-0.039334383,-0.0048702816,0.009514254,-0.008204485,-2.6069627e-33,0.067288734,-0.027681574,0.06901783,-0.0029904193,0.009305729,0.07653436,-0.032046348,-0.059653133,-0.032153796,-0.04723331,0.108091,-0.044299077,0.08959264,0.022550756,0.016415147,-0.001404775,-0.06360592,0.1265167,0.031700358,-0.05499457,-0.010143175,-0.003780991,-0.023785686,-0.02364852,0.097816564,0.019697784,0.00022073348,0.052600138,0.020664189,0.051846348,0.002888328,0.060703304,-0.104572,-0.046947468,0.036095973,0.053481128,-0.03719438,0.015828269,0.023012051,-0.050117992,0.035522223,-0.0013088451,0.08936571,0.0018281258,-0.03964734,0.0670686,0.0015238536,-0.023148797,-0.011934159,-0.029622525,-0.013300781,-0.016165243,-0.050366364,-0.0011324035,0.03307171,0.009826537,-0.05338886,-0.0050762445,-0.0113651175,-0.072431624,-0.09084358,0.013429369,0.0075171036,0.008986661,0.01275009,0.06655317,0.025303684,0.08596564,0.05873301,-0.0019588703,0.07843772,0.036084965,0.0878481,0.08980925,-0.043797478,-0.07014056,-0.059861034,-0.05450896,0.030352363,0.06869453,0.090958126,0.032374434,0.026000027,-0.028436365,-0.008793398,-0.09477811,0.055532362,0.094984494,-0.087322205,0.0018071135,-0.026703265,0.05257728,-0.07172778,0.03943287,0.09489588,-2.7811586e-08,0.052071694,-0.053576075,0.02067735,-0.085006684,0.0062461346,-0.019354535,0.0153036155,0.09048246,0.013770279,-0.0401315,0.007829043,-0.003149732,0.037344314,0.064203575,0.028719679,-0.06066901,-0.003782568,0.043199256,0.015703483,-0.036881585,-0.08841625,-0.043740418,0.039721813,-0.004207074,-0.044646706,-0.044893317,0.024969526,-0.010007451,0.03431076,-0.042151354,0.022515716,0.045579914,-0.03757681,-0.06517025,-0.05344136,0.025219927,-0.12527183,-0.01395944,0.024936847,-0.018741362,-0.012872276,-0.06892591,-0.041979663,0.017306805,0.025113318,-0.13378303,-0.04178861,0.009671274,-0.02334099,-0.030100368,0.04539394,0.06616533,0.00586529,0.0014955399,-0.030318001,0.0401741,0.027354728,0.00040625533,-0.035987083,-0.14586715,-0.026234588,0.07824167,0.058114916,-0.00016587765 +2.7.3.13,"The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides.",384,1.0,0.00086935156,0.028984573,-0.09856696,0.0005869564,0.040496964,0.05189975,0.040568266,0.035439532,0.087225884,0.06917126,0.042680837,-0.019494582,-0.0071491254,0.057452094,-0.019974787,0.004811077,-0.061425626,0.034169238,-0.028686112,-0.021539807,0.06917823,0.0103509575,0.047937796,-0.000493271,0.0043237237,-0.055889405,0.07686529,-0.022352364,-0.041124962,-0.025756212,-0.007620384,0.00246204,0.032421198,-0.059269976,0.063910976,0.08982122,0.02302803,-0.06664525,0.11036324,0.021164235,0.032886125,0.019212434,0.04443041,-0.024027742,-0.065925635,-0.0012164997,-0.016136149,0.07541367,0.030929375,-0.08978796,-0.09499366,-0.09178174,-0.03332389,-0.019023865,0.019813422,0.07926299,-0.015557064,-0.04241991,0.032004714,0.0015403631,-0.04878791,0.052604623,0.0979213,0.022182975,-0.014666444,-0.08363408,0.052344806,-0.084867395,0.0071961596,-0.004441503,-0.092125356,0.0024367566,-0.034881286,0.0013984918,0.01796247,-0.019820297,0.0030216437,0.057617825,0.033969846,-0.0016653613,-0.041049663,-0.05642494,0.06212653,0.019022139,-0.0740426,-0.031477127,0.042021062,0.022736654,0.12969102,0.050341588,0.008542363,-0.03938596,0.0111460695,-0.058485717,-0.09279579,-0.073520295,0.050935205,-0.013554468,0.101550885,0.016497774,0.0007195698,-0.033718318,0.015489503,-0.052775163,-0.037136286,0.0012893567,0.04752552,0.046612877,0.03926249,0.016196277,0.009094557,0.07933765,0.035812914,-0.056650214,-0.10862455,0.0468432,0.031221127,-0.07905195,-0.06991845,0.007072823,0.039457418,-0.0932451,0.05959174,0.018354546,-0.03100279,0.052780464,-0.12358785,1.5116789e-33,0.059316892,0.017443227,0.05577579,-0.036229443,0.06821,-0.026857285,-0.06813882,-0.042755164,-0.053993348,-0.053640835,-0.1034281,-0.06591326,-0.0062011518,0.036937837,0.033499375,0.010385579,-0.06263002,0.026734076,0.033278137,0.032603465,-0.037880816,-0.023960741,0.039384525,-0.030023819,0.0681689,0.077575184,-0.03348593,-0.004545251,0.03803486,-0.010036915,0.1360456,-0.040657658,-0.12886786,0.02304801,0.08798305,-0.0028538378,-0.02453907,-0.040573068,-0.0028339697,-0.026684197,0.010056977,0.06364645,0.0013233003,-0.006070069,0.0174713,-0.03528761,-0.058713563,0.09896001,0.07881588,0.09279138,-0.00637868,0.017420445,0.06690549,0.027129376,-0.053720538,0.05058442,-0.015705612,-0.042957913,0.038730048,0.025589332,0.012451426,0.046914488,-0.039674427,-0.0018929532,0.008872122,0.032624163,0.01427433,-0.02916109,0.07369245,0.009487189,-0.04939046,-0.05701944,-0.028163256,0.08694956,-0.064677104,-0.071753494,-0.02593728,-0.034573052,0.028284054,-0.021964395,0.052987583,-0.028199747,0.018397704,-0.023263887,-0.11125658,0.00122026,-0.059168674,-0.0031049398,-0.056068566,0.037991073,0.033418372,-0.04496366,-0.028025324,0.02765713,0.0006445875,-3.602013e-33,0.041080307,-0.07182004,0.039441496,-0.060497154,0.0053073554,-0.03969165,-0.009809185,-0.053340554,-0.020556912,-0.08369863,0.029933192,0.051886838,0.037113313,0.0040199384,-0.0032013354,0.036898326,-0.010366752,0.095042445,-0.053820886,0.003394699,-0.015469418,0.049988307,0.007899804,-0.07558472,0.036409725,-0.018989569,-0.012135237,0.11666174,-0.046831757,-0.0007665793,-0.0069269384,0.009594664,-0.056704257,-0.0844883,0.0029765337,-0.043114796,-0.079250544,-0.05655492,0.06090029,0.006331237,0.04532478,0.02055179,0.009707362,0.032842368,0.019967228,0.09747613,-0.088270284,0.009814146,0.0026687274,-0.026630087,-0.070104204,-0.025837231,0.00846017,-0.017338762,0.018244028,0.059420295,-0.0068820645,0.009893483,-0.03704261,-0.069067374,-0.015878458,-0.022306552,0.06595329,0.012721316,0.029341217,0.050781302,0.04436962,-0.018347818,0.075478256,-0.08086883,0.08442533,-0.016700028,-0.013300865,0.073079236,-0.055792563,-0.04036699,-0.13524964,0.018619047,-0.040684897,-0.00611526,0.028425891,-0.035226364,0.006199031,-0.07045707,0.029830834,0.0030948957,0.050188795,0.07215719,-0.008307731,0.03666079,-0.014569306,-0.03842219,-0.02032422,0.10464879,0.03858786,-3.2075445e-08,-0.0034860296,-0.10151801,-0.034875102,-0.07051639,-0.022359736,0.004883256,-0.029357491,-0.040785957,-0.01922413,-0.041875713,0.039773118,0.13311018,-0.0060937963,0.053019915,0.014482816,0.043314364,-0.104258135,0.027275598,-0.040036008,0.028597122,-0.095343925,0.024028108,-0.032682598,0.059782013,0.025446795,-0.032017045,-0.007890767,0.09344029,-0.041317303,-0.0132761495,0.041729283,0.08959863,0.00050424854,-0.008018789,-0.119777724,0.034455582,-0.08505848,-0.023015108,-0.006227993,0.054320604,0.058670986,-0.006330845,-0.074706234,0.00028922927,-0.004056461,0.06777663,-0.030937543,0.07951412,-0.075341135,0.0016213834,0.029248554,0.029264351,-0.07865119,0.010344326,-0.08677532,-0.017234735,0.0017644361,-0.008327801,0.02922169,-0.031426266,0.030024795,0.0056703757,0.12585841,-0.1039741 +3.2.1.206,Oleuropein is a glycosylated secoiridoid exclusively biosynthesized by members of the Oleaceae plant family where it is part of a defence system againt herbivores. The enzyme also hydrolyses ligstroside and demethyloleuropein.,384,1.0,-0.07011662,-0.022381702,-0.061376404,0.053333867,0.07490352,0.063333526,-0.04700723,0.052858032,0.022248607,-0.049908414,0.045641333,-0.006583756,-0.11581899,-0.045425013,-0.06895445,0.026935592,0.0040389295,0.03898312,-0.052561834,0.006091528,0.041895356,0.026030509,0.06281452,-0.016560433,-0.009444934,-0.0015076369,-0.021171894,0.023135953,0.07251577,-0.04205731,0.069357276,-0.0031613072,-0.08079573,0.011577251,0.0009991478,-0.0015036403,-0.009377656,-0.113069035,0.060944825,0.021563131,0.062328584,-0.042550974,-0.007008025,-0.031466153,-0.06629855,-0.030626433,-0.07449518,-0.024874622,0.02582666,-0.07626062,0.032169458,-0.073151916,-0.027951779,0.017152801,-0.0035602723,-0.026290316,0.0065999688,-0.028143382,-0.03122729,0.04914494,0.086418055,0.03156717,-0.010968903,0.01854807,-0.099171445,-0.003991092,-0.008222894,0.00590495,-0.008436285,-0.035593882,0.018552989,-0.050870247,0.006885596,0.115631066,0.0024961766,0.07226094,-0.0065630176,0.0076722326,0.020740468,-0.10803424,0.049052272,0.03948801,0.019678026,0.102445625,0.048242263,-0.06425922,0.043199643,0.10698023,0.00896392,0.014479262,0.04094701,-0.05113181,-0.0068088216,-0.02378508,-0.034024354,0.047577772,0.044359684,-0.07634359,-0.04198308,-0.0045577777,-0.09404246,0.050616443,0.024772543,-0.065538526,-0.06127935,0.053321,-0.017545933,0.045340344,0.06260893,-0.063794106,-0.036854155,-0.016699558,-0.004347188,0.058306277,-0.0480413,-0.015275941,-0.026442565,-0.077930495,0.058132757,-0.02729037,0.012731671,0.01828305,0.037997648,0.120999955,0.015325746,-0.008227297,-0.05487023,4.2379683e-33,0.062494755,-0.03170782,-0.06873628,-0.09787242,-0.0043614255,-0.00664715,-0.048546232,0.01540603,-0.010473829,0.028173495,-0.065432265,-0.04195931,-0.013237053,0.119538136,0.005759866,-0.065014236,-0.03907673,0.022668146,0.08188179,-0.05090756,-0.01875517,0.0999208,-0.010842301,0.004253046,0.02746075,0.010004476,-0.061134025,0.013627469,0.06090641,0.012262535,0.014381696,-0.1605848,-0.060592573,0.05502781,0.028838512,0.030132417,-0.00875858,-0.12132683,0.03365182,0.0593342,0.020082815,0.010655105,0.04713125,-0.014802989,0.055866793,0.074477166,-0.06858544,0.021749819,0.053562373,0.021312892,0.022883767,-0.02566166,0.095830426,0.02213708,-0.09096599,0.028923752,-0.062518254,0.022170095,0.0044709975,-0.026900865,0.009077544,0.045419343,-0.012415887,-0.07355095,0.009578547,0.033293918,-0.07425034,-0.015211123,-0.0006320894,-0.041671187,0.011212543,-0.05978579,0.06107836,0.05786031,0.082774915,0.008943539,0.07614732,0.06765964,-0.066589974,0.021553354,-0.06508272,-0.015889473,-0.061049,-0.01866441,-0.04236723,0.10249923,-0.03274631,-0.00837039,0.020665044,0.03198801,-0.027337858,-0.01253508,-0.019935254,0.015035787,-0.041868404,-6.0982597e-33,0.015220735,-0.058692,0.067995206,-0.001553661,-0.027528852,0.06596648,-0.12951867,0.055054344,-0.037301783,-0.0071072658,0.051650632,-0.009966794,0.041452315,-0.09784212,0.034658473,-0.018419122,-0.06841202,0.033884685,0.006855614,0.032901976,-0.08954738,0.027409041,0.01858381,0.035033934,0.15176177,0.030963982,-0.0040533505,0.023471285,-0.009131236,0.025460936,-0.012055675,0.067638576,-0.08862793,-0.05243509,0.008070032,0.056982666,-0.023325244,-0.05757819,-0.049465936,0.026838606,0.023036916,0.022918085,-0.00066137774,0.060249146,0.11182993,0.04941608,-0.103401735,0.026659295,-0.0031987957,0.030124255,-0.011976075,0.044516627,0.030118894,0.011086039,0.027377104,-0.025032202,0.057529077,-0.010408316,-0.052100983,-0.058081932,0.04339361,-0.03344537,0.007053638,0.051239967,0.027381338,0.08020195,-0.08763274,0.038199544,0.019273793,0.010584919,0.05814936,-0.014304258,-0.008029834,0.053036228,0.016389739,0.059126213,-0.015462941,-0.117007464,-0.05036943,-0.041625522,0.010021038,-0.0018560868,0.014498187,-0.11112109,-0.053350307,-0.005659824,-0.017155373,0.095854096,0.012524899,-0.01970771,-0.028480904,-0.032493483,-0.05142141,0.05460515,0.0064926054,-3.9521815e-08,0.04166338,0.0036493612,0.084128544,-0.014980816,-0.03678261,-0.123531,0.043176267,-0.04094612,-0.03903693,0.0032502173,-0.038539678,0.037646107,-0.022456368,-0.026513975,-0.02607033,0.01774959,-0.04880821,0.008075157,-0.009426078,0.017873673,-0.020078652,-0.04612962,-0.033062775,0.095559016,0.0030844517,-0.071535185,-0.0012279842,0.02259376,0.093559906,-0.01832687,0.054401934,0.07520328,-0.01148602,-0.0043650507,0.010460218,0.046994552,-0.034055132,-0.080160156,-0.023376556,-0.026388284,-0.027645402,-0.030507963,0.018647019,-0.013758869,-0.0014837827,-0.013994608,0.11625758,0.024235811,0.023467194,-0.073694974,-0.0023878757,-0.018049296,-0.057627767,-0.025467811,-0.11127101,-0.0650296,-0.033395015,-0.010530783,-0.010171827,-0.060457196,-0.07018789,0.014347541,0.20661296,-0.0026566805 +4.1.1.105,"The enzyme has been characterized from bacteria, plants, and fungi. Unlike EC 4.1.1.28, aromatic-L-amino-acid decarboxylase, this enzyme is specific for L-tryptophan.",384,1.0,0.018625382,-0.031801175,-0.035823382,-0.0705109,0.09752659,0.088824496,-0.08359177,0.044614702,0.055802997,0.004264067,0.03188596,-0.0927778,-0.09857116,0.084397025,-0.08062776,0.02917684,0.02407447,-0.05764954,-0.010730731,-0.033804893,0.053306103,0.08147325,-0.039039038,-0.010849838,0.0018669553,-0.04919098,0.014920387,-0.016536098,-0.03703176,-0.03335434,-0.0027830037,-0.05059192,0.02704269,-0.01300809,0.046959367,0.0819009,-0.06851767,-0.07330345,0.08003591,0.05930508,-0.027712174,0.0011544898,0.0034435338,-0.0560041,-0.021405634,0.031082457,0.023021137,0.023802495,0.009138141,-0.07274862,0.0040314808,-0.031775765,-0.0018298093,-0.012273859,-0.027101729,0.028181372,-0.025749063,0.015502164,-0.072043344,0.06420107,0.02744898,0.05258681,0.053891134,-0.016093234,0.058916748,-0.0011271917,-0.01853959,-0.10673007,0.074460685,-0.037839532,-0.065521404,-0.06208509,-0.005534193,0.083071314,8.955391e-05,-0.014391533,-0.0005449467,-0.025989747,0.02692569,-0.048422456,0.012672448,0.0042194724,-0.062081583,0.03689179,0.017076056,-0.0024821518,-0.025170283,0.10411451,0.04601407,-0.03905793,0.1134456,-0.028546812,-0.045179095,0.031962283,-0.020118028,0.036423184,0.0040029734,-0.033153586,0.012106815,-0.050580278,0.012438638,-0.01087733,-0.072927386,-0.13513911,-0.024429392,-0.0066076554,0.07094935,0.0135636935,0.04188237,-0.04253695,-0.017739791,-0.014063347,0.055181295,0.024274925,-0.010299334,-0.004006346,0.020330824,-0.08490036,-0.026023664,-0.00042455288,0.067255326,-0.035872668,0.08292953,0.09211147,0.005688049,0.09003246,-0.133611,-2.772743e-33,0.07593517,-0.009900548,0.06326954,-0.009432881,0.0053311735,0.02635376,-0.037282873,0.025467444,-0.04085137,-0.02034437,-0.08816801,-0.09490754,0.013666778,0.021983156,-0.005665556,0.04283173,-0.1048858,-0.008506113,-0.020470284,0.059220415,-0.040553987,0.03831662,-0.0656115,0.04517659,0.036137298,0.037640173,0.022306804,-0.0060988762,0.052556098,-0.008304361,-0.024231942,-0.08335226,-0.11772712,0.004098646,0.024378851,-0.011930504,-0.009487673,0.008867653,-0.03080482,-0.009841837,0.013671485,0.082093604,0.02195808,-0.023773536,0.075817406,0.019397687,-0.024060937,0.10927042,0.04786292,0.012252287,0.04264928,-0.04068404,0.044146657,-0.028134463,-0.033548914,-0.008420921,-0.054082595,0.09272927,0.05977508,0.042049527,-0.038854297,0.041163743,-0.06358742,-0.0050417953,0.02060081,0.012130977,-0.061593417,-0.03822801,0.0079461895,0.07558492,-0.049504656,-0.06791986,0.06806921,-0.0023845087,0.029382287,-0.1022734,-0.06622762,0.010648467,0.03367308,0.005140602,0.019487802,-0.011439396,0.0073982496,-0.06700501,-0.10381024,-0.032751605,0.044181436,-0.010432808,0.01887097,0.009175255,0.05002571,-0.019070081,-0.024490783,0.06951504,-0.0025609343,6.9065923e-34,0.04010268,-0.100566715,0.028649762,-0.0008371818,-0.0031536159,0.032669134,-0.014284888,-0.030258283,0.047784746,-0.02237831,0.14444566,-0.061056692,0.06691699,-0.039725643,0.07271405,-0.0006431427,-0.09744393,0.06757532,0.03470101,-0.0006598491,-0.028033536,0.019372793,-0.0028630036,-0.041155692,0.07425686,0.027313462,-0.045550182,0.10857349,0.014303867,-0.039873835,0.018705789,-0.0011049472,-0.04377557,-9.926941e-05,-0.05412635,0.018771779,-0.07502301,-0.0040836264,0.07483201,0.04709927,0.008205373,0.037003018,0.0517307,0.00430078,0.0012841386,0.063475326,-0.07706484,-0.009845132,0.061181378,-0.096182615,-0.018638587,-0.046703696,-0.020049311,-0.016881118,0.031250615,0.08710282,-0.04210144,0.044312403,-0.025000488,0.011571365,-0.063181385,-0.059648994,0.074860446,0.029982053,-0.016773298,0.024840575,-0.017610695,0.059133098,0.07005877,-0.026759334,0.08420458,-0.022171622,0.035086226,0.07461078,-0.07204755,-0.09171614,-0.067932025,-0.03397554,0.015856305,-0.023039287,0.035576776,0.008120624,0.014332194,-0.016008934,0.010922611,-0.07553284,-0.00045580696,0.11957533,-0.00038034513,0.0525812,-0.020867083,-0.04106261,-0.028217198,0.056474183,0.107827306,-3.080158e-08,0.05618911,-0.057661902,0.04253644,-0.05310084,0.003104345,-0.00068528915,0.029074013,0.021560265,0.04095311,-0.034212854,0.024258256,0.015968967,-0.09190047,0.04155637,0.050871003,0.0008542199,-0.06790053,0.038835794,0.010061349,0.09679412,-0.037282135,-0.03218153,-0.10162114,-0.047218774,-0.023849344,0.0036488005,0.00740926,0.09355917,-0.003690093,-0.04407053,-0.052118383,0.042116717,0.06727009,-0.025022084,-0.09313884,0.063956775,-0.12388832,0.0129690375,-0.03766225,0.04105563,0.0659443,-0.08841583,-0.053754725,-0.033160087,0.022713473,-0.08264561,0.0379861,-0.009260122,0.015943345,0.008238849,0.037233975,-0.03407483,-0.0026449903,-0.032990076,-0.027442155,0.019972166,-0.06905751,-0.06954443,0.019903654,-0.07886776,0.06223691,0.060317885,0.16210715,0.017775204 +4.1.1.106,"This algal enzyme, characterized from the green algae Chlorella variabilis and Chlamydomonas reinhardtii, is dependent on blue light, which photooxidizes its FAD cofactor. The enzyme acts on fatty acids in the range of C12 to C22, with a higher efficiency for C16 to C17 chains, and forms an alkane product that is one carbon shorter than the substrate. The enzyme can also act on unsaturated fatty acids, forming the respective alkenes, but does not generate a new double bond.",384,1.0,-0.06772649,-0.021077128,-0.09324802,0.016070293,0.013233241,0.03882054,-0.049230438,-0.0047418647,-0.004246391,-0.032607406,0.047769513,-0.106708795,-0.052955978,0.0010540357,0.01634258,0.12871762,-0.041279126,-0.05807929,-0.0670881,-0.039097905,0.076087415,0.013495879,-0.060748532,-0.00030239054,-0.0051086643,-0.033673704,-0.035193544,-0.0034936778,0.02945147,-0.081656225,0.007081854,-0.0038251071,0.0065869996,-0.036381662,0.07771959,0.0023505734,-0.015775597,-0.11855939,-0.010394551,0.060233485,0.028865214,0.002440882,-0.018652422,-0.015468051,-0.047124993,-0.037111156,0.0035007086,0.050924066,-0.0079661505,-0.08003614,-0.0790222,-0.0950624,-0.05755325,0.015414745,0.069573835,0.06423967,-0.072425395,-0.034899246,0.03322367,-0.024021925,0.075131804,0.015916292,0.045551643,0.0366734,-0.002578817,-0.043411616,-0.057454586,-0.13314904,0.011626785,-0.08302559,-0.095558524,-0.09119062,0.0047989683,0.0067079784,0.043245096,-0.00532948,-0.0037988988,-0.122827135,-0.017228248,-0.006257916,0.014722136,-0.012584636,0.009760073,0.07691983,0.07371634,-0.076961674,0.08607234,6.1217033e-06,-0.015756512,0.015768364,0.00017909166,0.013533993,-0.031761806,-0.06879977,-0.1191257,0.072013594,0.057551667,-0.019706376,0.016355546,0.0039498964,0.015205926,-0.037142362,-0.052333493,-0.10966862,-0.034970198,0.0010017822,0.056563586,0.11886657,0.011204948,-0.005421423,0.031553097,-0.0026716266,-0.012524931,-0.015348651,-0.03779434,0.08258368,0.0074525066,-0.085083455,-0.024127502,-0.0028242574,0.025127117,-0.09962688,0.036871668,0.027648386,-0.012493128,0.019549413,-0.09398795,2.9617421e-33,0.065587126,-0.0028740962,-0.009019521,-0.06933929,0.04621287,-0.083541766,-0.07857078,-0.043542683,-0.087935485,-0.07330669,-0.047138017,0.061282378,0.028147757,0.06647579,0.024598742,-0.041143097,-0.02883793,0.010580841,0.0037134606,0.03310441,0.010880894,0.07100347,-0.04969633,0.0029702305,0.03377907,0.022275811,0.03655226,0.026174583,0.030919729,-0.0046710987,0.06784987,0.024395224,-0.07762487,0.034480102,0.08696653,0.027216848,-0.041836776,0.00020180587,-0.09115999,0.01991004,0.025644455,0.06772791,-0.00834148,-0.022364687,0.07145934,-0.05059654,-0.0653592,0.08520174,0.071401134,0.070935905,0.018678524,0.015127609,0.04401394,0.0018422635,-0.052496575,0.073134184,-0.019060293,-0.010764988,0.0068554794,-0.028210934,-0.07241157,-0.01710604,-0.021640958,0.058186296,0.009536382,0.024311965,0.014972655,-0.00734878,-0.006412784,-0.014162243,-0.08375982,-0.00024475402,0.05429349,-0.026026988,0.0504479,-0.058249634,0.0007585771,-0.043371998,-0.036014732,0.012522543,0.012379371,-0.009874555,0.10075862,-0.11435714,-0.10033619,-0.030076923,-0.078486264,0.03342621,0.019254878,0.041882582,0.07632023,-0.034253735,0.03854621,0.01575413,-0.0028908013,-4.1956358e-33,0.086746365,-0.10633964,0.05879074,-0.0797672,0.038236607,0.041247178,0.0035253563,0.004508073,0.031716492,-0.0031948874,0.11996541,0.070526585,-0.012758769,0.040012557,0.017449377,-0.0004356954,0.017969841,0.07240324,-0.03236087,-0.020618342,-0.05011377,0.036972158,0.03675301,0.0633937,0.024580909,0.05730181,-0.016201155,0.018401269,0.013901882,0.014736475,-0.05362099,0.0049397475,0.0003120869,0.011413332,-0.014082287,0.032814518,-0.06150749,-0.013036016,0.0091889985,0.119724736,0.02814289,-0.04779292,0.0073450315,-0.019300995,0.01933066,0.056199316,-0.041761752,-0.020777669,-0.022130055,-0.08623839,0.03752417,0.05438253,-0.020918312,0.045590915,0.06678084,0.0934893,0.027413566,0.030571714,0.046811026,0.028814211,0.02875905,-0.055043835,0.058310535,0.0027949065,0.029293958,0.02468043,-0.054858834,0.0040174876,-0.027788691,0.058957275,0.097569935,0.075714596,-0.05838342,0.0523986,-0.006669387,-0.056564275,-0.025269615,-0.04197648,-0.081470735,0.0058421437,0.04054138,-0.014852905,0.028798798,-0.051335763,-0.037268717,-0.076364055,0.01999062,0.03082277,-0.03073081,0.008997612,-0.017089926,0.030391859,-0.018235732,0.04297376,0.09774824,-3.8698005e-08,-0.0075952443,-0.034713313,0.042523477,0.008040408,0.0046245847,0.045328714,0.043020558,-0.020359972,0.06142212,-0.057047017,-0.019024394,0.07735054,0.052684367,-0.003992218,0.03385697,0.03678204,-0.033802398,-0.07039918,0.014332207,0.041078527,-0.09686897,-0.05387186,-0.08596665,0.043567963,-0.05871362,0.01021704,0.050771642,0.12372745,0.012240758,0.015238124,0.027904285,0.082646556,0.02315485,-0.010312843,-0.084822945,-0.008490098,-0.030417414,-0.016845081,-0.099279106,0.09377166,0.041178323,-0.004005254,-0.06691127,-0.03619495,0.018074188,0.0072127953,0.020898644,-0.020156488,-0.034438092,0.05331559,0.045951918,-0.049874876,-0.03420874,-0.03853749,-0.087947674,-0.045714386,0.039770957,-0.0066098045,-0.09960494,-0.01786613,0.07558918,0.012584219,0.17028856,0.040965162 +4.1.1.107,"A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha-methyl-L-dopa.",384,1.0,-0.03845613,-0.037263706,-0.011340097,-0.08773587,0.0709508,0.033462968,0.017578198,0.007845238,0.08017504,0.060087103,0.0005309945,-0.027592652,-0.07568489,0.034013618,-0.025104566,0.10780012,-0.047150135,-0.045285095,0.025419837,-0.035737745,0.06240545,0.027519962,0.07027856,-0.03403178,0.0076074977,0.0766521,0.01863744,0.00081411237,0.009151511,-0.017678756,0.04817073,0.005138892,-0.038394414,-0.07136973,-0.018752735,0.055547208,-0.11414169,-0.039521262,0.035132375,0.021265127,0.052938208,0.0031695885,-0.056583237,-0.016191777,-0.078013375,-0.046024017,0.037358668,0.064591624,0.010498161,-0.050764356,0.00045845046,-0.06587995,-0.027136499,-0.0058911676,-0.03813284,0.015568261,-0.015822958,0.06363168,-0.055458806,0.031682312,-0.01973841,0.10007512,-0.00048502034,-0.003095266,0.018861022,0.005004139,-0.04345877,-0.06727974,0.012300768,-0.03793063,-0.07520309,-0.058097534,0.06909539,0.013650915,-0.025099171,-0.0023903232,0.020040063,0.07134007,0.07273897,-0.03941131,-0.0323497,0.0010044526,0.058644146,0.08051044,0.05501508,-0.009076266,-0.07035757,0.093469724,0.07350843,-0.0115607325,0.032573115,-0.031456318,-0.071010135,0.03126027,0.018417057,0.040312316,0.04315694,-0.010666697,0.0015779352,0.057989888,0.0019517654,-0.018738981,-0.08338849,-0.08768551,-0.1276936,-0.006801842,0.054067787,-0.003092857,0.04458209,-0.06393999,-0.037213877,0.0032336898,0.06749911,0.066399954,-0.047371008,-0.036637288,0.009860657,-0.047382735,-0.02085321,-0.024172377,0.011728699,-0.030214466,0.07346968,0.083068,-0.014526836,-0.01975036,-0.097172745,1.455614e-33,0.10452789,0.0065414067,0.020751499,0.04248972,0.03309853,0.056231257,0.0036000283,0.05761274,-0.06455356,-0.00843689,-0.09965485,-0.11207169,-0.0077881827,0.06589653,0.016500961,0.014664518,-0.028920198,0.011422616,0.11744717,-0.058715533,0.025193289,0.001678381,-0.007529049,0.022813866,0.052269656,0.104118146,-0.069082506,-0.0020921605,-0.019697314,0.0067604193,0.009877013,-0.115863375,-0.10279624,-0.013812995,-0.061787263,0.049026344,-0.10412753,-0.028588552,-0.054114927,-0.00877941,0.021629427,0.010173118,-0.0438857,-0.028470589,0.032277513,-0.0014745682,-0.032186087,-0.0013510754,0.021554308,0.051434174,0.027888305,-0.039141495,0.06435204,-0.035883438,-0.15807018,0.015047987,-0.046822213,-0.015770204,0.048338097,0.017994793,0.02381922,0.034760833,-0.01824355,-0.04078659,0.01837506,-0.009576823,0.02892195,-0.063023135,0.051230278,0.02995084,0.016564054,-0.0009653221,0.05223036,-0.078877375,-0.00070988596,-0.0042043678,-0.08600824,0.013833411,-0.0067732055,-0.0036258595,0.044468775,-0.059166066,0.06256281,-0.02644042,-0.015441198,0.016595379,0.030908393,-0.046322692,0.010315421,0.051714923,-0.0029016016,-0.12506606,-0.023045935,-0.01912137,0.03040339,-9.011223e-34,0.0061029205,-0.09572631,0.03028977,-0.06739321,-0.011700759,0.0241458,0.037791155,-0.033161644,0.040596258,0.027732514,0.020297622,-0.023617666,0.018517574,-0.043792743,0.053746764,0.009584252,-0.028171517,0.115613386,0.10376856,-0.03274972,0.011556243,0.050009437,0.02728093,0.016816732,0.028724935,0.031741966,0.06720924,0.039557878,0.040267542,-0.017913088,-0.027836809,0.045578387,0.0005603692,-0.03353556,0.002988024,-0.021651065,-0.10364216,-0.010491273,-0.01357274,0.029591326,0.036942385,0.04398871,0.012600499,-0.014756725,-0.0020049312,0.033197217,-0.08217831,-0.053714924,0.021046463,-0.07196611,0.077795066,-0.02048424,-0.024699772,-0.049921047,0.0513216,0.039959714,0.0042924937,-0.011127285,-0.0045340424,-0.051435787,-0.07012161,-0.031440996,-0.0141214775,0.07155143,0.04109441,0.11392582,0.013709775,0.095617265,0.057117127,-0.007734916,0.08217235,-0.033517275,0.027480612,0.10215289,-0.049343932,-0.039483722,0.007362335,0.00069944625,0.086232975,-0.0553562,-0.013498546,-0.07681254,-0.00045641343,-0.06643963,0.003907505,-0.047138184,0.030617323,0.12745962,0.002375669,0.075592756,0.026839497,0.04763912,0.029150391,0.045790248,0.12564187,-4.018728e-08,0.038748596,-0.06123172,0.005728312,0.056450557,-0.023285404,0.004980295,0.09637616,0.011193196,0.0116945105,-0.012732796,0.051688362,-0.076130696,0.060325008,0.019178793,0.04651463,0.05202726,-0.078497015,0.02180054,-0.02702388,-0.052935053,-0.012081512,0.07299307,-0.042840205,0.029036025,0.060372945,-0.093753,-0.076808736,0.046081893,0.038452562,-0.023945674,-0.06539365,0.06587571,-0.00030297297,-0.0324864,-0.057895243,-0.014878809,-0.05570088,-0.078290135,-0.019799422,0.020265397,-0.037365608,-0.02930719,0.062675,-0.04499187,-0.006968686,0.01764893,-0.006958362,0.0133367935,0.031267386,-0.022281155,0.05093701,0.08288614,-0.02638088,-0.05919276,-0.14517733,-0.019008098,-0.04764145,-0.04578973,-0.024909813,-0.14771667,0.0548629,0.015891504,0.11490238,-0.06330292 +4.1.1.108,"A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plant Petroselinum crispum (parsley), catalyses the production of 4-hydroxyphenylacetaldehyde directly from L-tyrosine. Tyramine is not formed as an intermediate. The enzyme has a low activity with L-dopa (cf. EC 4.1.1.107, 3,4-dihydroxyphenylacetaldehyde synthase).",384,1.0,0.008911479,-0.09913671,-0.07010677,-0.07799224,0.08708185,0.07559214,-0.039258707,-0.0053225537,0.0919841,0.029929139,0.03196664,0.027326252,-0.05493605,0.012871179,-0.04770684,0.05458765,-0.07412228,0.013519343,0.015770461,-0.10308959,0.023208374,0.02803215,0.06356048,-0.00072584744,0.07879227,0.0039968505,-0.0017448714,0.0008806963,-0.010401972,-0.0055539226,-0.016050026,0.01627441,-0.01987818,-0.11189639,0.0260643,0.06966728,-0.058037035,-0.04757973,0.06313001,0.010955871,0.029336995,-0.060093716,-0.08461299,-0.016462363,-0.10094276,0.0004969566,0.071082145,0.04827083,-0.014717344,-0.038943887,-0.051505163,-0.0275264,-0.024724063,-0.096249506,-0.07188517,-0.011537792,-0.017473184,0.06631643,-0.023145529,0.043571055,0.0367592,0.025341175,-0.012308487,-0.026958548,0.02804529,-0.017736102,-0.04831218,-0.042155836,0.03965765,-0.06523987,-0.07803931,-0.050509907,0.082138784,0.005332844,-0.042718217,0.023775617,-0.05216956,0.0066729723,0.08119842,-0.016116004,0.00709906,0.0014392743,-0.009123327,0.105140924,0.061511785,-0.0039421506,-0.0011330025,0.10953797,0.095205866,-0.0053166277,0.038684126,0.0023431329,-0.00056965445,0.033299103,-0.034025833,0.04746771,0.0036203996,-0.013425245,0.0138291195,-0.0071335915,0.013021443,-0.0084260665,-0.007884255,-0.07461895,-0.077737816,0.040939055,-0.036623463,0.07571786,0.0051921564,-0.046504177,-0.0044065313,0.040248666,0.039884776,0.013893206,-0.007755142,0.02885263,0.06436097,-0.10016748,-0.075069994,-0.039195538,0.0007256263,-0.019908162,0.0833235,0.124002196,-0.021433719,0.053816456,-0.079217374,3.3653456e-33,0.10312764,0.124360226,0.013036269,0.029097576,0.020159652,0.005563801,-0.055589397,0.06452473,-0.07926952,0.022862514,-0.086430416,-0.06983557,0.02245169,-0.034599073,-0.023184134,-0.026246225,-0.05928555,0.037459113,0.07117919,0.03301875,-0.009243143,0.07761742,-0.03709399,0.059331067,0.0022750588,0.069312535,-0.020683868,-0.037954632,0.018546259,-0.011359754,-0.020179275,-0.1282194,-0.06327771,-0.016008427,-0.0018509674,-0.0572781,-0.07236687,-0.038719963,-0.023524933,0.014093936,0.020278452,0.033644084,0.03450411,-0.046918493,-0.0014940305,-0.050733052,-0.010710253,0.09737737,0.01600521,0.009104921,0.08309618,-0.038506776,0.08175111,-0.0317828,-0.11190254,-0.0041229823,-0.008406097,0.027356314,0.10022885,0.0631316,0.025874998,0.009275102,-0.02548807,-0.007691285,0.007470564,-0.049186982,0.0061368826,-0.038202506,0.041238166,0.05813443,0.002015196,-0.017111855,0.04045424,-0.011148054,0.050322507,-0.017065635,-0.054801386,-0.020510225,0.03796972,-0.02275556,0.030907543,0.00048115276,-0.001254238,-0.028999127,-0.023940455,0.008287235,-0.03680276,-0.0016738323,-0.014309814,0.046341278,-0.03456796,-0.1071815,-0.03461726,0.034862682,0.014791272,-1.8388245e-33,0.039864905,-0.09930167,-0.009265847,-0.08163338,-0.030034227,0.014411194,0.028578619,-0.033642627,0.05547402,0.034787256,0.08071942,-0.030107554,0.06815826,-0.01418448,-0.03788521,-0.026315305,0.041886456,0.06725728,0.0029726028,-0.028213564,-0.028957939,0.031896085,0.02202703,0.048992343,0.03134809,0.09609617,0.000982452,0.029133251,-0.008639862,0.058726367,-0.009556638,-0.009004854,0.013582401,-0.035814106,0.0008852891,0.03737209,-0.10552116,-0.035177376,0.012119006,0.014836855,-0.016740425,0.0030659842,0.040347375,0.022121675,-0.03896903,0.0047953255,-0.080335386,-0.01436822,-0.044099648,-0.004329824,0.03222813,0.015507506,-0.0042830184,-0.023111472,-0.0004314409,0.04056698,0.010862551,-0.021789046,-0.035889126,-0.008798443,-0.022546098,-0.029783983,-0.0055901497,0.069174,0.045849103,0.097522,-0.0660289,0.10217789,0.058339145,0.005821393,0.07428026,0.031832226,0.043061867,0.12813108,0.022896755,-0.02421631,0.03762442,-0.02090488,0.061995715,-0.049715646,-0.010537896,-0.02639755,0.0043144906,-0.09062013,-0.02830054,-0.05783125,0.01720912,0.12741345,0.04735164,0.048171226,0.05375432,0.019998997,-0.03104299,0.04033529,0.12490744,-4.3076355e-08,-0.03216303,-0.057564143,0.025948571,-0.011233288,-0.02978938,-0.02133616,0.08663204,0.019623935,0.054462396,-0.03076948,0.01618041,-0.009682393,-0.019296875,-0.021032954,0.0036096347,0.023893643,-0.04135811,0.017575728,-0.053317886,-0.03481088,0.00929685,0.07487552,-0.09220119,-0.0020405408,0.07085664,-0.09523496,-0.069245175,0.019900013,0.037473664,0.0012265248,0.047775585,0.004264648,-0.056437172,-0.045846656,-0.06614294,0.07707999,-0.031755332,-0.011704601,-0.041376878,-0.014608026,-0.041105695,-0.041795004,-0.048634484,-0.030586466,-0.025278289,0.046853922,-0.08409607,0.008029218,0.03237186,0.040775996,0.06883436,0.053521466,-0.002824697,-0.09273596,-0.15207785,-0.002360798,0.015060956,-0.033252273,-0.010245119,-0.16043377,-0.018870845,0.017227411,0.22125135,-0.035507437 +4.1.1.109,"A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plants Petunia hybrida and a Rosa hybrid, catalyses the production of phenylacetaldehyde directly from L-phenylalanine. The enzyme is specific for L-phenylalanine and does not accept other aromatic amino acids as substrates.",384,1.0,-0.04472605,-0.06809203,-0.08602401,-0.053291805,0.089146174,0.11246431,-0.055687442,-0.03103658,0.054720674,0.014760727,0.08580241,0.015572258,-0.101254605,0.01809108,-0.022139143,0.05823164,-0.104898535,0.034184597,-0.034437235,-0.056861095,0.007754846,-0.009027029,0.009604455,0.031457257,0.03776344,-0.005788123,0.04611887,-0.017495366,-0.013698701,-0.03746304,0.010245784,-0.041638296,-0.0073187584,-0.08447875,0.03802538,0.05534538,-0.05059233,-0.072695516,0.061653983,-0.016144117,-0.00012895447,-0.07345053,-0.038632166,-0.0819141,-0.0893993,0.002542659,0.026219005,0.006235815,0.026813924,-0.07929089,-0.0523742,-0.02123261,-0.05439877,-0.05270599,-0.04148039,-0.03909013,-0.009779181,0.034685697,-0.003543699,0.013833257,0.01991537,0.03579734,-0.020753978,0.004347203,-0.021921428,-0.08802555,-0.035857763,-0.030489886,0.058855988,-0.062782496,-0.037988875,-0.096569024,0.06871234,-0.008824401,-0.0019440292,0.025580157,-0.05914491,0.056737162,0.0589877,0.003748854,-0.012863797,0.0068073655,-0.014191513,0.081903644,0.09563504,0.030178517,-0.05814924,0.072429165,0.050487127,-0.053876728,0.01731117,0.034310702,-0.04879429,0.029715568,-0.0326083,0.042270627,0.0132310055,-0.04818625,0.014962138,0.02298806,0.008447862,0.040992673,0.02149893,-0.08726609,-0.114588656,-0.017466623,-0.04766381,0.038141027,0.023623765,-0.02563172,-0.0178687,0.012364375,-0.015926806,-0.034833718,0.022811707,0.036565036,0.0146013,-0.09223258,0.000591111,-0.00404009,-0.026418844,-0.040214296,0.08017111,0.14774364,0.00027083058,0.0018111225,-0.13700336,3.1283975e-33,0.11717377,0.06509899,0.012944213,0.003567291,0.0064473324,-0.0072166277,-0.0416066,0.039162833,-0.0462308,-0.032728147,-0.06647819,-0.040893953,0.0273496,-0.05370793,-0.0046483474,-0.01668709,-0.05532811,-0.0037542921,0.08693613,0.010084181,0.037133686,0.05276075,-0.019710641,0.113457054,0.043358173,0.058559675,-0.02610935,-0.02881978,-0.0019098481,0.01187692,0.0063241664,-0.12937453,-0.0745692,0.013724164,-0.021426933,-0.030940231,-0.11742151,-0.08879216,-0.007832874,0.092223205,0.03227195,-0.035412665,0.06137077,0.028346274,-0.011809054,0.006341448,-0.04498114,0.067164674,0.0018775946,0.030704452,0.04384674,-0.011253701,0.09448911,0.024726057,-0.15256901,-0.010052102,-0.02223298,-0.012035387,0.039974596,0.049038906,0.024111757,0.0322865,-0.009932467,0.00935107,-0.008151401,-0.041705266,-0.010854735,0.014058017,0.088740595,0.0924978,-0.0053546387,-0.067252636,0.059111975,0.00012978182,0.090451695,-0.08521548,-0.01882734,0.04449813,0.039276067,0.029477878,0.007015403,-0.005553722,-0.042569093,-0.019185867,-0.05846312,-0.01951799,-0.023332763,-0.014715172,-0.024904104,0.0169938,0.029314322,-0.092603,0.034966573,0.03233577,0.0020857037,-3.0791615e-33,0.076219335,-0.09135808,0.055020105,-0.08985561,-0.037604623,0.0064396234,0.053697236,-0.011904126,-0.022654023,0.00967313,0.03301539,-0.020026386,0.09495152,0.039523963,-0.044161778,0.07423614,0.028462738,0.051794566,0.08956334,0.032149483,-0.02875359,0.05253221,0.01412878,0.038815357,0.05712468,0.049397368,0.015243375,0.0111052245,0.03712771,-0.014687205,-0.01942548,0.02509338,-0.038811427,-0.04656098,-0.06379544,0.0042701736,-0.108592495,-0.028601794,0.0071917353,0.061033342,0.019589646,0.010129365,-0.023642534,0.042337976,-0.00078183215,0.0042302394,-0.038114857,0.012550311,-0.05308836,-0.053164285,0.054724418,0.07163771,0.0042146803,-0.025985517,-0.005865471,0.04582889,0.040207047,0.010318884,-0.055720787,0.0037940063,-0.026452998,-0.111968964,-0.0019065642,0.100463435,0.004671826,0.09917415,0.031040104,0.033758506,0.055293594,0.030322084,0.068347834,0.04581653,0.07339649,0.13773943,-0.02488738,-0.026657531,0.019229004,0.012930125,0.03637615,-0.020624276,-0.023328105,-0.09633495,0.03904618,-0.11074617,0.027723502,-0.05218362,0.023697032,0.07029936,0.028877726,0.0042024665,0.032623097,0.034953527,0.014804805,0.06050912,0.1124936,-3.7866133e-08,0.00868234,-0.103917636,-0.0053370097,-0.0432799,0.043063365,-0.0023944147,0.05988146,-0.050721757,-0.020422956,-0.008576145,-0.022388443,0.0019761336,-0.010254545,0.0054078223,0.024645332,0.0659304,0.014895593,0.025601285,-0.018319564,0.003167094,-0.053155217,0.084333114,-0.10879518,0.01721503,0.016920807,-0.019951524,-0.00932788,0.03962917,-0.017755954,-0.02353522,0.03722,0.03552919,-0.06508557,-0.05312025,-0.06156225,0.066714466,0.03580029,-0.047954842,-0.048392747,-0.02114752,-0.032286875,-0.0114773,-0.029489657,-0.021064585,0.010490649,0.03300931,-0.053367533,-0.041469462,-0.00077515707,0.027119907,0.08037381,0.028565513,-0.014939984,-0.09235638,-0.11657051,-0.0069142077,0.003883351,-0.032402176,-0.033638515,-0.09816491,0.008892826,0.026297642,0.18351482,-0.03541358 +4.1.99.23,"The enzyme, purified from bacteria, is part of the anaerobic pathway for cobalamin biosynthesis. It binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate.",384,1.0,-0.026419448,0.0027810505,-0.112241924,0.010331556,0.05941125,0.07435678,-0.113452494,-0.02310295,0.01569424,-0.013613087,-0.0046729674,-0.08004374,0.037288938,0.028466476,-0.046477277,0.016568305,-0.06361179,0.0011642781,-0.024731401,-0.07756638,0.016492294,0.038745712,-0.07487115,-0.006560372,0.058983278,-0.0022217382,0.044400055,-0.023500025,-0.04701466,-0.034510992,-0.01754562,-0.021527749,0.118132785,-0.027608708,-0.009486401,0.16463469,0.019324556,-0.02043378,0.14951333,0.024237704,-0.0065319315,0.034931183,0.0353594,-0.032929335,0.05269221,0.014764533,0.021990016,0.020890571,0.037013892,-0.07358759,-0.07886794,-0.012671016,-0.06612378,0.023526745,0.00067520945,0.017109066,-0.010868031,-0.016914466,0.0053783786,0.025494333,0.07672277,-0.08122883,-0.020361518,0.016777698,0.019418782,-0.06653736,0.089853935,-0.06613768,0.067957506,-0.02181664,-0.008111174,-0.036095727,-0.01503463,-0.04316275,-0.021003153,0.05239221,-0.0029171405,-0.04886257,0.013844382,-0.013555271,0.0040951553,0.004009658,0.030816503,0.042302605,0.052662272,-0.014623348,-0.070364155,-0.023613239,0.06550624,0.05073345,-0.04941995,0.021174785,0.016953062,-0.054773804,-0.08934541,0.016311122,0.02145866,0.04791553,0.029685222,-0.022733524,-0.0012456259,0.09386192,-0.050557513,-0.036559567,0.0048259576,-0.05027011,0.08732775,0.1728193,-0.03891435,0.01662353,0.050864734,0.03853659,0.046282183,0.0042683575,-0.010943799,0.11067702,0.059680693,-0.04785577,-0.10867023,0.07642622,0.024138726,-0.0018023694,0.021003107,0.009282816,-0.041736845,-0.014165636,-0.044024028,1.7151937e-33,0.08817648,0.053122938,0.0016924188,0.024663858,0.022667391,-0.015979508,-0.1059629,0.017419778,-0.023413803,-0.033170532,-0.027093133,-0.036736775,0.046390604,0.006926432,-0.064948894,-0.07328151,-0.031609394,-0.03200459,0.060565908,0.009670205,-0.0371109,-0.016374392,-0.038324047,0.035313856,0.018753868,0.057238426,0.054774098,0.010012472,0.0036422166,0.018463174,-0.08542689,-0.0114919245,-0.08656696,-0.059605483,0.029061737,-0.01779618,-0.092906475,0.01199537,0.010123282,0.07314322,0.008793514,0.035132986,-0.046104323,-0.02688256,0.046038363,0.034253687,-0.053381015,0.09878126,0.016965672,0.09945575,0.03698991,-0.03229032,0.11498138,0.009594223,-0.08393108,0.0025274942,0.0053040804,-0.071418546,-0.014019192,0.100044206,0.04059273,0.040629,-0.041668516,0.09322594,-0.0068448554,-0.0026092893,-0.013020651,-0.054568373,0.029348617,0.05695744,-0.025987785,-0.042581435,0.075291246,0.08611972,-0.013905402,-0.028841602,-0.046147663,-0.036134418,0.03999639,-0.061687157,-0.009548407,-0.012732335,-0.022479337,-0.047969785,-0.037136536,0.017409353,-0.01137458,-0.048401818,0.0023148283,-0.039812494,-0.022417828,-0.033407114,0.025644092,0.018091002,-0.01427372,-2.0220791e-33,0.082228005,-0.07178902,0.018292572,-0.09100774,-0.07803286,0.06794169,0.0064627454,-0.077563666,0.05474848,0.052508183,0.04986553,-0.029854765,0.029999325,-0.031284373,0.011255879,0.006399685,0.035613593,0.04227853,-0.032508574,-0.026012294,0.025655562,0.028818091,0.003229612,-0.032951213,0.06994662,0.07244477,0.009306667,0.07445382,0.039136566,0.12037683,-0.010085631,-0.06649874,-0.03315284,-0.062403373,-0.05770841,0.109158136,-0.027559767,0.018286794,0.047551516,-0.01836064,0.014421563,0.054513138,-0.01991594,0.09396287,0.030629288,0.060861878,-0.010274329,0.062378135,-0.014667023,-0.076366626,0.052294187,-0.015966984,-0.057726663,-0.026445808,-0.003350195,0.053694792,0.0014406752,-0.02247182,-0.041652557,-0.09833156,-0.05165558,-0.06544418,0.036212184,-0.012216986,0.037804026,0.03394373,0.040734723,0.044378098,0.013565196,0.034341384,0.008258389,0.029409366,0.053619687,0.06821723,-0.057263725,0.014679238,-0.07684739,-0.03320362,-0.019644665,-0.012536752,-0.053718325,-0.010789531,0.0035908334,-0.07545998,-0.008475344,-0.11919467,0.03865765,0.08486513,0.040916864,0.06874275,-0.08389743,-0.015057195,-0.013083595,0.0036275527,0.05738596,-4.166291e-08,0.06606974,-0.08015348,0.023412613,0.009764245,-0.027869454,0.13004625,-0.056842964,-0.041313726,0.111200474,-0.033302125,-0.014836656,0.0694337,-0.0048999884,0.031955354,-0.04326045,0.010285461,-0.033088032,0.010405257,-0.033825252,-0.005049175,-0.08213222,-0.024448693,-0.10713992,-0.01958693,0.05834728,-0.109133355,-0.023418477,0.03790393,-0.04661746,-0.045464706,0.020784248,0.01476469,-0.009015649,-0.026919812,-0.07560796,-0.051305395,-0.04305893,-0.04323709,-0.004411085,0.0050712493,-0.019104486,-0.023686996,-0.12744163,0.057261016,-0.052709334,0.0068552354,-0.023629244,0.040498372,-0.035018366,0.052131206,0.056157757,-0.039437372,0.029890405,-0.0002888348,-0.039356876,0.01852645,-0.013533526,-0.05165965,0.021544745,-0.027521173,-0.039022204,0.038036965,0.13610263,-0.0881955 +4.2.3.195,The enzyme was identified in the roots of the plant Arabidopsis thaliana (thale cress). The product is a semivolatile diterpene that acts as a local antifeedant in belowground direct defense against root-feeding insects.,384,1.0000001,-0.0774738,-0.024171576,-0.054999404,0.011078793,0.048361074,0.049441535,-0.07417447,0.05236566,0.028611971,0.029261727,0.08629934,-0.017217886,-0.02415959,-0.053454205,-0.074870825,0.046470135,-0.047131173,-0.00036754823,-0.033318784,-0.07477728,0.04723179,0.07092626,-0.014755478,-0.016276065,0.03518201,0.008146217,-0.0118100755,-0.0053816065,0.0554761,-0.05057649,-0.019482974,0.05349142,0.07588437,-0.014268501,-0.019006442,0.102561444,0.0027560242,-0.10232393,0.081492074,-0.014183653,0.07853289,0.0016582398,-0.027699672,-0.0317756,-0.070707716,-0.051687356,-0.0037015472,0.05773191,0.008543069,-0.008631066,-0.022447908,-0.02863678,-0.059027355,0.09342682,-0.023196395,0.024991063,0.06909183,0.0005066764,0.024056714,0.048306286,0.07528426,0.021544686,0.029280875,-0.0066642812,-0.025357803,-0.07364745,-0.032729812,-0.010276555,0.030230056,-0.089674376,-0.02694606,-0.06359474,-0.043060612,-0.049340405,0.028150432,0.027912492,-0.047352094,0.024381505,0.0021788394,-0.026027717,0.050460294,-0.0102732,0.11127596,0.07974332,0.058046598,-0.014928212,-0.0025578723,0.029805224,0.11980195,0.021455146,0.02529806,0.005055905,-0.046587143,-0.006719017,-0.06130722,0.06929739,-0.01070063,-0.03497034,-0.10040325,0.0313675,0.018607285,-0.0037411419,-0.09480005,-0.08864851,-0.053035226,0.03529707,-0.08439438,-0.03322334,0.015389606,-0.025940802,-0.02087756,0.0022694585,-0.04164602,0.026553713,-0.039674748,-0.036478497,-0.016925326,-0.043910943,0.046012376,-0.034601133,0.03068889,0.015489317,0.015019624,-0.022148829,0.0027270245,-0.017042354,-0.13659224,2.328891e-33,0.02363362,0.065798886,-0.04933223,-0.10659649,-0.053001396,-0.06894364,-0.071346544,0.16542597,-0.055068225,-0.063357584,-0.02200368,-0.061511558,0.033790566,-0.027118297,-0.03682967,0.008872437,-0.031303175,-0.04879874,0.06409746,0.004002501,-0.0054426068,-0.037953466,-0.07197852,-0.018437123,0.015816152,0.0161271,-0.009124158,0.012253162,0.07113501,-0.009770166,0.06801006,-0.09718861,0.004591426,0.014724894,0.09785696,-0.009625458,-0.040413477,-0.051877018,-0.15435475,0.014611328,-0.012271943,0.019070793,0.004286868,-0.04017335,0.08869516,-0.010324639,-0.10222064,0.020015072,0.11219666,0.014063414,0.032946877,0.023731047,0.13798648,-0.026584521,-0.053843673,0.051037427,0.0015727461,0.012739774,-0.032583624,-0.002292157,-0.060782004,-0.035542887,-0.03311744,0.015801882,-0.061138093,0.04641858,-0.105705135,-0.06686758,0.018021652,0.067370005,-0.07913794,-0.011415797,0.027382387,0.0032365313,0.0018519977,-0.04356451,0.0019520579,0.07401048,-0.01915444,0.055323806,0.004900093,-0.09817238,0.03828444,-0.013538214,-0.080291554,-0.07974979,-0.029128924,-0.027368562,0.055173814,0.0063896906,0.07998315,-0.017775267,-0.09304731,0.053639617,0.020652812,-2.9265162e-33,0.010774691,-0.05181424,0.034104772,-0.008961311,-0.033988636,0.07845872,-0.022419194,-0.039499827,0.02947115,0.015703443,0.052948162,0.029267872,0.04608965,-0.033322096,0.08597695,0.055674482,0.09544303,0.032491125,0.015533005,0.014989592,-0.039358325,0.11914162,0.03744186,-0.032388076,0.0014477908,-0.0059123,0.0909562,0.07527271,-0.019563703,0.037252992,0.04100523,-0.037081134,-0.011541588,-0.013841141,-0.093602434,0.0424829,-0.08677909,-0.060937073,-0.0018855355,0.03389994,0.05481196,0.025238426,-0.004683127,0.07877466,-0.023104813,0.051114276,-0.08546814,0.06491012,0.008443287,-0.019475512,0.027115697,0.07033505,-0.010294913,0.05576211,0.02740002,-0.007907302,0.007719059,0.021876693,-0.00396686,-0.008210391,0.0019807564,-0.04838697,-0.0013319199,0.006933471,0.03926704,-0.0010733728,-0.0576593,0.07565192,0.035799332,0.023887007,0.06527878,0.08109966,-0.0147913955,0.03650755,-0.076906584,0.03318302,-0.007177351,-0.08025865,-0.0810996,0.0064352783,0.0038461066,0.02367683,-0.038682893,-0.033945765,-0.016169991,-0.112032995,-0.053808223,0.0982894,0.032804843,0.0387169,-0.008438967,0.016311599,-0.03892225,0.07948595,0.12706658,-3.456064e-08,-0.006452492,-0.0630028,0.020621894,-0.06339641,0.03554931,-0.020256607,0.03797095,-0.05232795,0.0013603587,0.036001902,-0.01885102,0.031032618,0.03112717,0.008682799,0.065189004,0.016204966,0.041429978,0.033350524,-0.04627673,0.021630233,0.011104844,-0.008816639,-0.058021456,0.012134794,-0.0014819358,-0.07884058,0.029704249,-0.02446795,-0.019836102,0.021267591,0.0019530853,0.0720947,0.039457068,-0.034696545,-0.11834696,0.10653518,0.03508138,-0.0209302,-0.065978676,0.02003824,0.009602866,-0.035630226,-0.06623551,-0.03172819,-0.049540173,0.022677006,0.025777807,0.032749895,0.034241028,0.05449317,0.017280662,0.015512795,-0.01384424,-0.031738847,-0.058358867,-0.024559986,0.017082283,-0.040059824,-0.0114866765,-0.04251815,-0.023512412,0.01921527,0.19065411,0.0012636285 +4.99.1.12,"This enzyme, found in Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It catalyses the insertion of Ni2+ into the cofactor forming a covalent bond between a carbon atom and the nickel atom.",384,1.0,-0.048862435,-0.03938871,-0.07948924,-0.004393278,0.038032006,0.019248096,-0.028388279,-0.009855309,-0.0035354698,-0.031548843,0.03548565,-0.079342775,-0.0873513,0.0010777882,-0.061706003,0.008945237,-0.077308744,0.023899913,0.036419354,-0.04606566,0.00082072313,0.043937445,-0.01201424,-0.025898684,-0.008349298,0.057182636,0.05580453,-0.10794705,-0.0019498828,-0.07522608,0.01093491,-0.07024916,0.010504708,-0.05634744,0.04715992,0.011728171,0.023372253,-0.019797806,0.0019079897,-0.00991055,0.061413024,-0.009966517,0.078280695,0.007669401,0.04322316,0.0494447,0.05994736,0.029135969,-0.0030712045,-0.06751771,-0.06542537,-0.049864445,0.022728838,-0.010124987,0.075388685,0.055951793,-0.0050874143,-0.07491276,0.028084874,0.015563337,0.14049043,0.0357333,0.029864708,-0.0062354323,0.05598271,-0.0130723305,0.039170813,-0.08085596,-0.0268478,-0.047900558,-0.013644317,-0.09474519,-0.020105187,-0.019859891,0.0034253711,0.02628472,0.016133483,-0.022483189,0.08262036,-0.0027348034,-0.021199243,0.0672926,0.058755822,0.08237343,-0.006607637,-0.0075349994,0.10144704,-0.01731218,0.027184924,-0.009928359,-0.027052047,-0.0051585627,-0.018062094,-0.024976734,-0.13633162,0.016087731,-0.030709513,0.07266364,-0.019592332,-0.009751616,0.055844188,0.05969302,-0.053807143,-0.09534685,-0.10203132,0.030677274,-0.032725908,0.08921048,0.10776714,0.09376976,0.01556422,0.032384112,0.0043846355,-0.0036480178,-0.02449459,0.04173716,0.035548676,-0.064326294,-0.014190562,0.050837316,0.04673461,-0.0100857215,-0.049169175,0.053483136,-0.07323679,0.054187786,-0.08018192,1.1973354e-33,0.03655496,-0.0028908548,0.0014775528,-0.04599505,0.02816229,-0.06614365,-0.10871456,-0.046648942,-0.05817757,-0.085953325,-0.037792973,-0.06995904,0.03348551,-0.008135666,-0.042974837,0.024854397,-0.05945882,0.034546554,0.056786943,0.041600607,-0.036382295,0.07233068,-0.09697504,0.07183707,0.052883375,0.0822278,0.038561914,-0.0651406,0.05074854,-0.011465581,0.07277796,-0.10315082,-0.028967025,0.010808958,0.09584016,-0.049666356,0.0712563,-0.0047104307,-0.04650591,0.029253999,0.010344163,0.05530301,-0.007025471,0.020302907,0.026993303,-0.022436956,-0.0165608,0.085455135,0.048636872,-0.025413975,0.023302747,-0.012331509,0.048967022,0.023484286,-0.0542741,0.074009016,-0.037162352,0.051753037,0.10182601,-0.06725441,-0.010644471,0.013439027,-0.018369788,0.07026551,0.020948706,0.036627594,-0.023646424,-0.050534125,0.05103232,0.07065362,-0.1379698,-0.0040137945,0.00045843117,0.024972366,-0.011980454,-0.071204446,-0.03262696,-0.052391123,0.019871574,0.003888462,-0.015829818,-0.025241414,0.026151178,-0.08378669,-0.025351666,-0.07687736,-0.15552169,-0.05894289,-0.042412125,0.013833393,0.0391964,-0.0022990108,-0.06909002,-0.017466897,0.019954652,-2.5955795e-33,0.049892124,-0.10571735,0.053540286,-0.05424478,-0.029654345,-0.011118623,-0.043228727,-0.07404453,0.051303886,-0.017592851,0.040207833,-0.038487077,0.08586315,0.05925104,0.022834172,0.018294454,0.0107872775,0.12780677,0.01613846,-0.006041917,0.019483512,0.06433905,-0.022024473,-0.02335941,0.0039534294,0.07951982,-0.07070691,0.04714099,0.06637963,-0.004911115,0.017273707,0.033226334,-0.05862342,-0.11274273,-0.10079524,0.017323418,-0.0040303534,-0.020195635,0.021758744,-0.03317275,0.0012802554,0.021275043,0.019410433,0.044673264,-0.0012765793,-0.016385,-0.069678,0.031780053,-0.0037328505,-0.027580457,0.04101291,0.060907982,-0.04445091,-0.005598373,-0.001518031,0.07329265,0.034735516,0.015603045,0.039445985,0.004407178,-0.09339601,-0.039967567,0.09968817,-0.029609395,0.048894115,0.020360343,-0.037140273,0.06255392,0.06848407,-0.04412422,0.038598888,0.13604937,0.059557483,0.058287118,-0.06328909,0.0026020596,-0.026109194,-0.060747884,0.010703262,0.0033615578,-0.0137916505,0.016888544,0.065314636,0.0008905807,-0.004254879,-0.053812277,0.047561843,0.15735048,-0.02616713,-0.024854476,-0.030554004,-0.03220085,-0.06792464,0.05792491,-0.0515325,-3.3457827e-08,0.012096845,-0.057688333,0.0036743532,-0.04857656,-0.0052894554,0.07655204,0.019318726,-0.020580031,0.049150176,-0.0698666,0.048858736,0.09894822,-0.041548423,0.00043073043,0.05129189,-0.0023034152,0.012307007,-0.07502995,-0.049039893,0.026926607,-0.022429395,-0.004138691,-0.04901025,0.053158525,-0.04372177,-0.06589795,0.057326972,0.063513264,-0.051876772,-0.035714447,-0.06279548,0.07069231,-0.014964683,-0.01439868,-0.043783087,0.03361396,-0.052661028,0.01186034,0.011758156,-0.018220892,-0.017006569,-0.006662418,-0.036632255,-0.0047821742,-0.05814424,-0.018254278,-0.006472125,0.010129647,-0.025901176,0.011814765,-0.052280564,-0.0035949713,-0.037695657,-0.001492835,-0.05940668,0.032474853,0.0663009,-0.06528127,-0.015904479,-0.008082407,0.016922962,-0.00507076,0.15919675,0.021716086 +6.2.1.51,"The mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to the phenolphthiocerol/phthiocerol polyketide synthase.",384,1.0,-0.065597095,-0.048361987,-0.07901298,-0.010496465,-0.002139351,0.020780206,0.031369403,0.04261171,0.043268457,0.02198325,-0.028155677,-0.082669966,-0.0014263167,-0.00010983894,-0.04602788,0.075446144,-0.04780459,0.052563902,-0.041626703,-0.06478138,0.045843303,0.05545561,0.012678119,-0.027124131,0.036332488,-0.012997367,0.05810428,-0.0032342526,-0.028370168,-0.058302853,-0.01350456,-0.08366951,0.018641701,-0.013526677,0.07711008,0.13361621,-0.025711976,-0.12692976,0.10445916,0.0045607113,0.083831586,-0.02608415,-0.028377809,0.010883804,-0.04999733,0.043311037,-0.06703109,0.049604155,-0.004862082,-0.03962147,-0.06546485,0.0017815366,-0.06030371,0.033995803,-0.0010384914,0.11654315,0.05877902,-0.046060476,0.008316616,0.0150065785,0.009778717,-0.026013723,-0.0018187576,0.07050867,-0.045612335,-0.08353984,-0.00537978,-0.0008267079,0.014459509,-0.037067592,-0.10037632,0.0008793277,-0.0058710733,0.03790134,0.072802916,-0.050332274,0.011605605,0.0056549767,-3.11301e-05,-0.008188909,-0.012803494,-0.042991877,-0.0034863355,-0.041650698,0.029266112,-0.06790077,0.11769026,-0.013082941,0.004225923,0.09546997,0.049621604,-0.08840798,0.035180148,-0.08491364,-0.059598632,-0.042202376,0.12156775,-0.034386765,0.017382285,-0.043833997,0.010522439,-0.040309202,0.0029999705,-0.036252044,-0.049680218,-0.00014732328,-0.064215794,0.046533562,0.049719457,0.052352384,-0.04551074,0.05373954,0.009620036,-0.021418508,-0.00024998936,0.09445585,0.019547189,-0.03984021,-0.03971399,0.009331404,-0.034539822,-0.096102834,-0.015765466,0.052616343,-0.115120284,-0.002869918,-0.099673234,2.5021009e-33,0.05190724,-0.01018905,0.008518488,0.01018209,0.0069437684,-0.031085154,-0.11637133,0.001269591,-0.017842922,-0.14579213,-0.022351542,-0.069400474,-0.004966949,0.062345974,-0.070966594,0.041145183,-0.086099274,0.03610485,0.08183954,0.09484237,-0.01455031,-0.015393315,-0.014951098,0.06463823,-0.0057174843,0.08094134,-0.07312351,0.02093003,-0.038460277,0.023688778,0.02831655,-0.03641618,-0.0562768,-0.010406848,0.035109702,0.000324614,0.007924253,-0.114305206,0.06569648,0.015193344,-0.016024763,-0.07656726,0.0071877027,0.005632914,0.044120893,-0.017604282,-0.024364416,0.04784204,-0.031379018,0.08894154,0.0123630185,-0.08421175,0.098412916,-0.03314458,-0.047119383,-0.02251295,-0.067001395,-0.07336408,0.0036723097,0.023970686,0.034338694,0.0733659,-0.010493606,0.08500859,-0.057446525,-0.027608693,-0.00893088,0.009375119,0.0102513395,0.09012552,-0.03828253,0.0018677912,-0.0070055886,0.020928646,0.049634125,-0.0010877297,-0.11170456,-0.04027602,-0.044478104,0.0031761623,0.068004765,0.020915762,-0.016263533,-0.054701276,-0.0017078652,-0.03925796,-0.036964368,-0.05631916,-0.04135154,-0.012712027,0.04948347,-0.078565106,0.006246886,0.09072707,0.01398956,-5.8342437e-33,0.14151737,-0.11535102,0.057761822,-0.07745448,-0.04436961,-0.022486884,0.065999806,0.015795784,-0.0010497565,0.01277998,0.018042827,0.021203384,-0.016923996,-0.037332818,-0.010282298,-0.0337662,0.014507509,0.037641484,-0.034840845,-0.03675759,0.015188257,0.0029387323,0.044772197,-0.01204242,0.0041200574,-0.01930147,-0.116337165,0.08696317,0.031544965,0.029746292,-0.0068723173,0.0034462584,-0.028691087,-0.03552453,-0.024447646,0.010885963,-0.084804766,-0.018319858,0.06413551,0.03126655,0.08978299,0.05249067,-0.031894226,0.008176854,-0.02112699,0.046924584,-0.064496756,0.0134847555,0.03457184,-0.084133886,-0.025372963,0.056645136,0.050558902,0.023062337,-0.002196779,0.11820412,0.050251983,-0.008830704,0.009144956,-0.05273992,-0.09783031,-0.022444367,0.04832776,0.025165595,0.0067519546,0.07817145,0.05506429,0.08841826,0.07041969,-0.013204021,0.052950818,0.03899343,-0.028230818,0.005972644,-0.0750294,-0.047209106,-0.052322958,0.015038331,-0.01385592,0.011356674,0.0045989007,-0.0071812705,-0.0006160162,-0.1144835,-0.021626614,-0.052591022,0.052363954,0.07780074,-0.021832865,0.024573412,0.013994609,0.09249967,-0.016967343,-0.006951837,0.039004423,-3.8494935e-08,0.013040262,-0.07301023,0.05968652,-0.016683912,0.06423813,0.047704145,-0.05219911,-0.035680283,0.026038822,0.0062019075,-0.03615104,0.03894169,0.041945033,0.017045835,0.07956997,0.0667659,-0.043876134,-0.05607681,0.041204154,-0.029187877,-0.0886497,-0.0139712505,-0.025579045,0.09464653,0.034438826,-0.026302926,0.04391544,0.06519959,-0.011298414,0.04918372,0.020926412,0.020319527,-0.07134799,-0.009668003,-0.0524334,0.0133541385,-0.053671937,-0.101265356,-0.017832035,-0.02297791,0.045362256,0.03579525,-0.039270338,0.040800396,0.016931843,0.08375636,-0.005112754,-0.022742102,0.017464716,0.052436236,0.011349979,-0.016018167,-0.036320955,-0.01939948,-0.061765324,0.023772178,-0.01901665,-0.01801337,-0.037124008,-0.0035359585,-0.011212539,0.06454315,0.15408827,-0.058957137 +6.2.1.52,"This is an alternative activity of the firefly luciferase (EC 1.13.12.7), which the enzyme exhibits under normal conditions only when acting on the L-enantiomer of its substrate. The D-isomer can act as a substrate for the CoA---ligase activity in vitro only under low oxygen conditions that are not found in vivo. The activation of L-firefly luciferin to a CoA ester is a step in a recycling pathway that results in its epimerization to the D enantiomer, which is the only substrate whose oxygenation results in light emission.",384,0.99999994,-0.05473126,-0.04967453,-0.0254543,-0.0036743283,0.13061263,0.002350759,-0.039923828,-0.025246756,0.035736214,0.0016658964,0.043756377,-0.0031277959,-0.0805296,0.029256929,-0.0070798355,0.034438867,-0.08216564,0.0146448575,-0.08835938,-0.013708573,0.025831183,0.018596303,0.0060106297,0.019429231,0.014100714,-0.021175327,-0.0022607269,0.015603691,0.044792347,-0.102321945,0.035406157,0.02251008,-0.0497698,0.020257013,-0.009681351,-0.03744173,0.0043134987,-0.005679033,-0.027582714,0.024859123,0.06518397,-0.0927979,-0.07227108,-0.026799088,-0.14825812,-0.053148024,-0.05261687,-0.078771934,0.034921218,-0.03110126,0.052585676,-0.024960095,-0.04010271,0.08452476,0.005916666,0.0064999852,-0.011679621,0.007933208,-0.037731055,-0.06431977,0.039097775,0.057893712,-0.030408874,0.06510915,0.03816837,-0.088802576,0.05403983,-0.042656746,-0.034772087,-0.105635524,0.019663084,-0.044376805,-0.060645476,0.0024920295,-0.046207212,0.06546245,0.02999519,-0.011173197,0.012354457,0.04835858,0.08018108,0.008253047,0.055742517,0.1261746,0.018986775,0.034757223,-0.031128071,-0.005421233,-0.011735239,0.10858775,-0.010787215,-0.001985547,-0.07732914,0.04029492,-0.07264584,0.044041973,0.059100553,0.018035121,-0.0017464645,0.012161017,-0.093101695,0.039902203,-0.08774851,-0.03587634,-0.06831394,-0.07413798,0.023571078,0.06611245,0.021288224,-0.04612356,0.08834832,-0.036916964,0.094081685,0.033756733,-0.048160158,0.025068482,-0.005986735,-0.0030998073,-0.016994378,0.047118668,0.036950033,0.07371853,0.070595674,0.08411788,0.01309571,-0.0116832,-0.07693169,-3.3009052e-34,0.061441675,0.05317877,-0.01112135,0.029301543,-0.049487647,-0.090026304,-0.07977433,0.04002017,-0.09884261,-0.038206834,-0.048191905,0.03241531,0.033228215,0.059845734,0.057776418,-0.044196185,0.04270545,0.013829607,0.011704711,-0.03943575,-0.0044609625,-0.0062359,0.010661686,-0.00012939284,-0.02323227,0.073687375,-0.06630975,0.0686627,0.04239333,0.027495556,-0.024735428,-0.043677535,-0.018781103,0.020501252,0.06864178,0.014747586,-0.03568687,-0.014048129,-0.04035976,-0.0037249897,0.074366145,0.019047145,-0.07717238,-0.024726626,0.053418968,-0.042635184,-0.06477326,0.09395488,0.06315523,0.066368565,0.050770577,-0.043327857,0.11591324,-0.092777334,-0.0042519625,0.07583516,-0.06710724,-0.091200285,-0.006978578,-0.04065024,-0.01537551,0.045115493,0.0054932004,0.068907246,0.060012117,-0.019251946,-0.0015371385,-0.03727647,-0.023651691,-0.011494987,-0.082160585,0.04079954,0.07792565,-0.017129336,0.055558067,-0.053961337,-0.0037154665,-0.013134467,0.031419773,-0.001769777,0.039404158,-0.05783105,-0.023694845,-0.019414455,-0.011547789,-0.071474545,-0.043096986,0.008186751,-0.030417789,0.07944743,0.07613703,-0.058096357,0.002089042,0.022966411,0.006120458,-9.83364e-34,0.05832527,-0.09225865,-0.01234497,-0.09662572,0.0016623917,0.09216495,-0.014361898,0.0068523306,-0.025366964,-0.011838216,0.04541513,0.037420843,-0.069368124,-0.054051556,-0.02095211,-0.051339056,-0.014257109,0.051403094,-0.001663599,-0.042127427,-0.04993763,0.044427324,0.018696312,0.024616448,-0.0033068438,-0.0012449012,0.011299025,0.08652978,-0.053527936,0.035401836,0.046148065,0.042942725,-0.014168821,0.015163247,-0.025885535,0.09690392,0.03935818,0.017316531,0.035664964,-0.06582046,-0.050395664,0.041739512,0.054258905,-0.07704597,0.023361724,0.05004121,-0.008081058,-0.07893988,0.0045898557,0.0022535708,-0.007855876,0.0032995618,-0.11261027,0.057661384,-0.02784629,0.038230885,0.019139292,0.04158009,0.055079278,0.014913142,0.06121816,-0.04393314,-0.01416172,0.076888956,0.01921589,0.07855153,0.018417634,0.112158425,0.034304995,-0.03944191,0.11817918,-0.036693733,0.023051344,0.07883239,-0.0058243726,-0.06569884,0.0020581058,-0.06291477,-0.02416676,-0.0075036013,-0.088624574,0.021678552,-0.09246288,-0.032880522,-0.031148221,-0.10391863,-0.024163743,0.042680796,-0.06060658,-0.04587806,0.009612194,0.006285959,0.03167205,0.051726345,0.09317156,-4.21475e-08,0.022959907,-0.074732825,0.0012616012,-0.0126323495,0.03750692,0.022607356,0.06853179,-0.04122537,0.016730757,-0.045856033,0.018290753,0.05287838,0.074437976,0.022595845,0.13960221,-0.035327494,0.016038032,0.027223734,-0.053215865,-0.016456652,-0.046771225,0.010826929,-0.028996259,-0.03731696,-0.02964066,-0.054856263,0.020573456,0.08513817,0.0664183,-0.005852563,0.016391415,0.05112241,0.032670468,-0.029425414,-0.13425139,0.0039313436,0.008241997,-0.062497333,-0.045099188,0.04842641,0.04744036,-0.029273095,-0.009932049,-0.03785211,0.0015435294,-0.01202468,0.050293062,0.030284936,-0.025822237,0.026777986,0.04787476,0.0056618513,-0.0688204,-0.04624005,-0.13604856,-0.053657826,0.01537981,0.022469796,0.02884889,-0.10708169,0.046850923,-0.026794689,0.09247641,-0.052727513 +1.8.2.6,"The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. The enzyme from the bacterium Paracoccus pantotrophus contains a molybdoprotein component and a diheme c-type cytochrome component. The enzyme successively oxidizes the outer sulfur atom in [SoxY protein]-S-disulfanyl-L-cysteine, using three water molecules and forming [SoxY protein]-S-sulfosulfanyl-L-cysteine. During the process, six electrons are transferred to the electron chain via cytochrome c.",384,1.0,-0.113883525,-0.029164603,-0.072321646,-0.027593464,0.022897849,0.007078955,-0.081992015,0.043523196,-0.035751652,-0.025542043,-0.022559637,0.001921093,-0.031034168,0.008371999,-0.08282284,0.05033711,-0.08282485,0.039753914,0.009989438,-0.01819269,0.009863914,0.044106573,-0.07711359,-0.04062851,0.03050124,0.12114027,0.02079522,-0.014674276,-0.08085874,-0.028418865,-0.022007732,-0.008221844,0.01784995,-0.008585615,0.024565704,0.04573426,-0.042235814,-0.06126709,0.099745706,-0.005926559,0.04197926,0.10273094,-0.03064721,0.003944961,-0.03669283,-0.016155938,0.013440921,0.06362661,0.020343741,-0.06748051,-0.02466147,-0.052320268,-0.02665484,0.10471741,-0.0031355163,0.005131986,-0.03456591,-0.01860799,-0.01893935,-0.037815392,-0.03270597,0.06942812,-0.0468907,0.027298879,0.031103106,-0.11207566,-0.042591427,-0.016538147,-0.011922358,-0.03580475,-0.070769176,-0.012852387,0.036021367,0.037510738,-0.045732845,0.011804959,0.014924674,-0.04516362,0.115217716,-0.032667544,0.011666758,-0.048296534,-0.01708173,0.14181621,0.049864665,-0.019392356,0.02494982,0.014892853,-0.024660233,0.0066111293,0.030548688,-0.029144082,-0.0063430713,-0.0803413,-0.1415419,0.020016197,0.0043619853,0.069316864,0.016262457,-0.015430736,0.044405725,0.04143598,0.04758345,-0.13850068,-0.028905036,-0.00343482,0.04353898,0.11709422,0.003963732,0.04846856,0.0035352083,0.035218675,0.0014148843,-0.07373116,-0.043980796,0.057338454,0.014560752,-0.025346475,-0.047870193,-0.033719804,-0.008917517,-0.04203796,-0.028829925,0.028340379,-0.03945797,-0.010893597,-0.047154553,3.9468463e-34,0.07902042,0.018979535,0.008566448,-0.07969292,-0.03142939,-0.032517437,-0.038273465,0.056287557,-0.042130977,0.030955357,-0.08198846,-0.029988581,0.0028037054,0.008728514,-0.020114895,0.06417912,-0.06798554,-0.026338736,0.061173894,0.025617283,0.0314673,0.03620363,-0.060084388,0.01185803,0.06570475,0.019282207,-0.030004425,-0.04513149,-0.023781043,0.02732622,0.08854562,-0.03133006,-0.075808056,-0.015424878,0.03248502,-0.019643258,0.012983348,0.0036618726,-0.025107283,0.016723832,0.005366379,-0.016025377,-0.008614676,-0.05720625,0.0028803353,-0.06593549,-0.033153057,0.08522206,0.07131664,0.0815462,0.062819675,-0.16479921,0.12937728,0.003995383,0.0029448215,0.058998976,0.027683204,0.011439011,0.085097246,0.07176375,0.029519,0.050573017,-0.03075893,0.0014487319,0.029454725,0.028981192,-0.016917733,-0.023354687,-0.01945729,0.06413048,-0.110914186,-0.049671732,0.017781755,0.005545098,-0.035063077,0.00421067,-0.009547784,0.011766425,0.05751434,0.025219355,0.02123909,-0.090988815,-0.003465896,-0.008685154,-0.047610376,-0.004538002,-0.019475192,0.009587393,-0.06775371,0.053737752,0.07756534,-0.06350887,-0.047955435,0.015634155,-0.012166018,-3.377498e-33,0.059387773,-0.079913,0.023805156,-0.10248849,-0.0603145,0.054329168,0.026086494,0.01174185,0.015655726,0.049335573,-0.029556062,-0.0036743295,0.036310256,-0.018387102,-0.0024462796,-0.018235838,-0.049705036,0.088078715,-0.015555372,0.007638973,0.00036720038,0.11179434,0.061978403,0.008805258,-0.0072140144,-0.0041962694,-0.0024244534,0.061289027,0.06654322,0.08108623,-0.010897523,0.025318034,-0.00029180275,-0.04093324,-0.048864063,0.09132842,-0.04466522,0.06135671,0.061173696,0.0030861145,-0.030732842,-0.002898041,0.04549021,0.12716396,0.032483228,0.03928855,-0.04519781,0.031061964,0.017203448,-0.011035555,0.008083928,-0.0070630405,-0.0030786754,0.04182379,-0.00114595,0.057185054,-0.068819806,-0.037521467,0.0040152436,-0.076830894,-0.09372547,-0.10232133,-0.036744114,-0.031608835,0.021516133,0.025291136,-0.06516751,-0.013641252,0.037594836,-0.06174495,-0.042256627,0.0009555038,0.020586165,-0.010362329,-0.048054885,-0.045670472,-0.069921926,-0.014240675,-0.0035640257,0.07463521,0.0021054395,0.06462701,-0.02279395,-0.10911905,0.03563718,-0.014877088,-0.024362035,0.10795691,0.008253866,-0.015942987,-0.006689622,0.060382977,0.009807913,-0.005895895,-0.022379085,-3.7846096e-08,0.0048372024,-0.07039958,0.113714755,0.0067528267,-0.006415595,0.06902514,0.07902879,0.0663776,0.042683475,-0.017279442,0.038552728,0.14292426,-0.030799864,-0.025358856,0.06300262,0.04835107,-0.10525538,-0.04764751,-0.024094008,0.0073135626,0.00033331575,-0.06937346,-0.05814507,0.12188928,0.03823195,-0.022858677,0.06250781,-0.01992498,-0.068005696,0.02156451,0.022897325,0.07435715,-0.03857553,-0.02485126,-0.0883571,-0.0225166,-0.0066702,-0.015125815,-0.0070481845,-0.04150371,-0.0037649502,-0.01478515,-0.16007242,0.0295953,0.0047319527,0.02404647,0.0039470363,0.08712349,-0.015377469,-0.020256704,-0.006288406,-0.020580497,-0.03881905,-0.08847518,-0.06315539,0.013967223,0.027507912,-0.059136104,0.03988146,-0.014159693,0.032914083,0.013740613,0.15800469,0.011085906 +1.13.12.24,"Ca2+-regulated photoproteins are found in a variety of bioluminescent marine organisms, mostly coelenterates, and are responsible for their light emission. The best studied enzyme is from the jellyfish Aequorea victoria. The enzyme tightly binds the imidazolopyrazinone derivative coelenterazine, which is then peroxidized by oxygen. The hydroperoxide is stably bound until three Ca2+ ions bind to the protein, inducing a structural change that results in the formation of a 1,2-dioxetan-3-one ring, followed by decarboxylation and generation of a protein-bound coelenteramide in an excited state. The calcium-bound protein-product complex is known as a blue fluorescent protein. In vivo the energy is transferred to a green fluorescent protein (GFP) by Forster resonance energy transfer. In vitro, in the absence of GFP, coelenteramide emits a photon of blue light while returning to its ground state.",384,1.0,-0.045366596,-0.05010912,-0.0027270233,0.008678938,0.035964906,-0.078060664,0.02700765,0.06531147,0.06913208,0.08867177,0.02047285,-0.060975894,0.0048914216,0.09133793,-0.0117193,0.11076292,-0.035000745,0.020281823,-0.074023925,-0.022569317,0.02894869,-0.023805369,-0.05556497,0.01168195,-0.09441532,0.017744418,0.0052253515,0.036046214,-0.007508382,0.0008552801,-0.017583271,-0.06975119,0.027111746,-0.067181684,0.052899063,0.020731017,-0.04315078,-0.112066634,-0.06518176,-0.0061402507,0.011795037,0.042188212,-0.013817619,0.027165392,-0.025611466,-0.05831441,0.081360474,-0.070111334,0.0069916546,-0.0013100021,-0.010160717,-0.022641553,-0.050884232,0.0893445,-0.0330975,0.06064538,-0.09789058,0.015447675,0.020641606,-0.104209475,0.009480102,-0.024602134,0.035426285,0.0060875188,0.03198741,0.020193832,-0.064231046,-0.016077999,-0.035904877,-0.025894592,-0.058697157,-0.04057935,0.11052779,-0.0054133874,0.0040181847,0.027912946,0.042517826,-0.0073590935,0.038609754,-0.029660678,0.07485259,-0.08795695,-0.025656223,0.087272525,0.13352539,0.038763434,0.10721397,0.036043767,-0.021820769,0.031923484,-0.016216667,0.0063050045,2.416067e-05,-0.05418515,-0.081367955,-0.0075885598,0.00969762,-0.00984786,-0.0029930978,-0.016990561,0.050895054,0.032191403,0.02022976,-0.05531325,0.003608622,-0.02388599,0.020271203,0.13338709,-0.006770439,0.043522663,0.031070288,0.0146341575,0.04919813,0.037094817,0.024082316,0.17209299,-0.050417863,0.016028095,-0.010989244,-0.028735468,0.026653554,-0.053979542,-0.041476764,-0.040346738,0.01428971,0.039927535,-0.10359398,2.7408295e-33,0.062424123,-0.0014848559,-0.008988274,0.053829692,0.018728368,-0.08270825,-0.028700955,-0.03268064,-0.14581017,-0.02108636,0.03133485,0.03783978,0.07929517,0.03537765,0.045541566,-0.054852027,-0.05906668,-0.04999312,0.05239318,0.035848446,0.056270715,0.0051781284,-0.022976255,0.014820485,0.021565365,0.025625275,-0.04488174,0.027040148,0.003805445,-0.003225415,-0.017563224,-0.014461527,-0.057304192,0.028285483,0.10830952,-0.044861443,0.07323433,-0.018393202,-0.04691248,6.06705e-05,-0.04794975,0.002726756,-0.0047178585,0.022740278,0.09632374,-0.077722475,-0.05036877,0.0637912,0.038469072,0.055250697,0.03684219,-0.073594466,0.040222473,-0.03264306,-0.027728224,0.055065632,-0.05362631,-0.05190937,-0.029423324,-0.04633386,0.0016528988,-0.041123625,-0.01348304,0.058082275,0.046466704,0.0837297,-0.07342274,-0.001192352,-0.03737109,0.033848587,-0.059553068,0.02418062,0.03394898,-0.04893059,0.045348845,0.036878876,-0.033236317,0.025667585,-0.027996054,0.07361856,0.005466713,-0.019883966,-0.035526857,-0.013060185,-0.08922893,0.0019882566,0.067953885,0.02511192,-0.014406903,0.0179428,0.11407994,-0.055622797,0.07159612,-0.06699458,-0.10058114,-2.9398003e-33,0.07022994,-0.056431696,0.0045346767,-0.012926354,0.071909495,0.02939759,0.025293656,-0.0015020912,0.08821937,-0.061003562,0.03435792,0.07311485,-0.046043694,-0.04908685,-0.004999841,0.024299162,0.0031276587,0.025743606,0.022739282,-0.09793776,-0.04977963,0.014554832,0.075516015,0.037209306,0.0048909853,0.054019116,0.052011173,0.03644167,-0.01719864,0.056460775,-0.11263493,0.056688104,-0.0024352225,0.01432488,-0.04195008,0.04625924,-0.028784499,-0.07636589,-0.010763957,0.10627553,-0.001725369,-0.04425488,-0.035265733,0.07090348,-0.06329517,0.07581649,-0.061394826,0.038441185,-0.055380702,-0.011878712,-0.039005928,-0.0015266953,-0.05785713,0.021722132,0.051341902,0.069214836,0.056165744,0.062086724,0.03699929,0.08543166,0.025893362,-0.042842984,0.02620788,0.0014427238,-0.0022434625,0.061853644,-0.021072255,0.047869183,0.030244496,0.032876812,0.080488175,-0.017046979,0.0050164075,0.027586468,0.0361045,-0.026534835,-0.06529719,-0.06266934,-0.039781377,0.031622782,-0.0096217245,-0.0015867332,0.023405775,-0.071940295,0.011506199,-0.039146733,-0.05043346,0.0039048528,-0.020050008,-0.07709523,0.018005317,-0.026205678,0.004709515,0.026995094,0.09238268,-4.5962416e-08,-0.0069065425,-0.06713894,-0.0031038423,-0.0125734825,5.439648e-05,0.032553162,0.02754871,0.025968553,0.046778217,0.0066563645,0.045934636,0.009189681,0.010137948,0.014083976,0.0078019425,0.09171938,0.030820513,-0.07408829,-0.06601313,-0.019218836,-0.14163816,-0.031476513,-0.09120942,-0.01943361,-0.043952234,0.006884933,0.0010523358,0.015165059,0.004739497,-0.0058818995,0.036251824,0.030563155,0.045220215,-0.10202084,-0.12758422,-0.03235454,-0.06850027,-0.05582227,-0.07925203,0.04767236,-0.022486925,-0.0027535912,-0.07799887,0.010704393,0.004608159,0.05536521,0.05568345,0.036363445,-0.04998648,0.03445762,0.0019497466,-0.047413226,-0.032796137,-0.107388265,-0.13543923,-0.023031114,0.022987377,0.040859304,-0.029246012,-0.024687106,-0.039101318,0.017370727,0.12532425,-0.06380382 +1.14.11.58,"The enzyme, characterized from the bacterium Rhizobium tropici, catalyses the hydroxylation of C-2 of the fatty acyl group that is ester-linked to the 3-hydroxy position of the amide-linked fatty acid.",384,1.0,-0.048751403,-0.063014045,-0.114406854,0.06382703,0.011934909,0.058589578,-0.08987482,0.056399707,0.0076253605,-0.024243562,0.039205,-0.13393551,-0.025305532,-0.0020558182,-0.034516215,-0.0022213834,-0.0341124,0.008590477,0.005765991,-0.07279965,0.034999955,0.043808922,0.009067181,0.002664392,0.034751702,-0.0073142317,0.053590257,-0.019528674,-0.030036021,-0.08397658,0.028814781,-0.03236504,0.027806323,-0.043497402,0.06948837,0.056243755,-0.0359893,-0.048813794,0.09504674,-0.024655769,0.018517397,-0.03172484,0.06713866,0.001721962,3.8998045e-05,-0.026336325,0.024557676,0.10892899,0.06323723,-0.052797813,-0.09670821,-0.057335995,-0.07206883,0.06283454,-0.023716182,0.047073893,-0.016708922,-0.066858426,-0.04465073,0.03380618,0.030502621,0.014182004,-0.009499655,0.03921498,-0.04815014,-0.10721376,-0.005581892,-0.07733486,0.029465992,0.029146181,-0.10039833,-0.09811188,0.019277908,-0.04953817,0.019863741,-0.03459012,-0.042460874,-0.02415793,0.028009858,-0.051969796,0.0409165,-0.031554144,0.024731914,0.06885324,0.0391134,-0.024184583,0.037342023,-0.034649264,0.07225594,0.032012362,0.046606395,0.024942523,0.024526378,-0.017840939,-0.10128762,0.021695435,0.066951215,0.008436667,0.035808135,-0.010288083,0.04379633,0.035897516,-0.006951858,-0.1214869,-0.07205826,-0.047645453,-0.048675004,0.11704853,0.050989576,-0.011666949,-0.03380122,0.013216647,-0.033202235,-0.020162676,-0.012037322,0.055807717,0.09244651,-0.069572024,-0.02854106,-0.05515301,-0.042223033,-0.05489641,0.009325088,-0.06463969,-0.014302043,-0.023122504,-0.12494242,2.8786087e-34,0.023640305,0.031076238,-0.02592673,-0.036247626,0.012387217,-0.005129437,-0.13423383,0.028536495,-0.052656543,-0.051849786,-0.027360963,-0.038558044,-0.011165173,0.043207344,0.005901043,-0.040975664,-0.0033218125,0.062464803,0.030376801,-0.007613002,-0.005461801,0.062731326,-0.002247783,-0.032571856,0.037422694,0.026066,0.046565782,0.017915906,0.034804776,0.010998918,-0.030102117,-0.0021059401,-0.09451333,0.010804791,0.114385374,0.0050268685,-0.022909889,-0.009752294,-0.031021804,0.08807863,0.024379686,0.017290236,0.014015536,-0.081836134,0.038500227,-0.015688473,-0.019246416,0.1090903,0.057940178,0.03739264,0.060942486,-0.029910127,0.12985419,0.07287887,-0.043682344,0.011633672,-0.075954914,0.026534878,0.016802104,-0.025041968,-0.030786842,0.04870034,-0.019156886,0.019900704,-0.08660927,-0.04947442,-0.059760533,-0.029044813,0.0149029605,0.1413127,0.0080369115,0.0089256875,0.092520975,0.07768624,0.065670475,-0.040387202,-0.08734211,-0.030129192,0.06455269,0.01048896,-0.01663046,-0.002320063,0.048902452,0.0018624101,-0.016747236,-0.016718876,-0.08900998,0.015558882,-0.03319536,0.018918945,0.018107826,-0.044744756,-0.04698693,0.05940705,0.016268939,-2.5088958e-33,0.11648053,-0.06532598,-0.0002685248,-0.075163215,-0.018207058,-0.039340816,0.008979877,-0.045369625,0.045438137,-0.060422327,0.087133095,0.047017034,0.054253727,0.0141662285,0.06617168,-0.036280658,0.02742726,0.018542515,-0.024017869,-0.04134679,0.062048625,-0.0802911,-0.018793158,0.033945482,-0.0044149337,0.03634676,-0.0067778467,0.12841156,0.031238332,0.07548759,-0.004531112,-0.0019984182,-0.034067415,-0.052845735,-0.030695077,0.11976843,-0.0717937,0.034657013,0.008391023,0.04414505,0.081820734,0.018505462,0.012305199,0.04615975,0.06657337,-0.016581966,-0.030618848,0.02755556,-0.043985464,-0.10371793,0.029672835,-0.042647347,0.06581545,-0.017764805,0.007072276,0.11938073,-0.05656511,-0.010400924,0.0046737995,-0.023395093,-0.045960724,-0.03598345,-0.0046558203,-0.005787487,0.0005644063,0.016158214,-0.0071931393,-0.015171568,-0.005188971,0.01757617,0.0601333,0.035674393,-0.024987878,0.099569105,-0.05411197,-0.032229446,-0.030791566,-0.03799015,-0.008062572,0.010202964,0.068454206,-0.013227062,0.049309447,-0.085549966,-0.069029324,-0.05816839,-0.010304568,0.042560477,-0.01811504,0.04182775,0.048341017,0.033228878,-0.026359418,0.07958896,0.068934746,-3.491852e-08,0.012578372,-0.104539596,0.070946895,-0.035528786,0.007310868,0.07894094,-0.038794097,-0.048798908,0.07354466,-0.061039288,-0.054925054,0.059954897,0.0016398177,0.06508409,0.0066453204,0.0812726,-0.03815839,-0.026862042,-0.0363186,-0.009118974,-0.05654216,-0.035324067,-0.07975413,0.022282481,0.032099783,-0.02946663,-0.02449091,0.028000899,-0.066894874,0.013114071,0.014831634,0.030258091,0.03766344,0.024066767,-0.027170386,-0.0011285623,-0.0066525163,-0.078027084,-0.04951851,0.0119777685,0.09910696,0.07455938,-0.06992032,0.021537801,0.034899935,-0.0026106245,-0.05928684,0.03918927,-0.024689201,-0.022125818,0.052713603,0.015478771,-0.03341791,-0.015271964,-0.05152626,-0.045355417,-0.05171106,-0.032395735,-0.060501006,-0.033651,0.011407308,0.06227692,0.16446188,0.024089422 +1.14.11.59,"The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).",384,0.99999994,-0.07951815,0.03794919,-0.084091626,0.0019074348,0.04170515,0.10363894,-0.036943838,0.02428693,0.052127223,0.0020435124,0.051456075,0.008920901,-0.040170103,-0.023733918,-0.09905698,0.12627433,-0.04124019,0.02268124,-0.072734796,-0.034914937,-2.9513074e-05,0.04327888,0.039197426,-0.0026383253,-0.0029871925,-0.028907593,-0.026244504,0.019713629,0.009356962,-0.066944905,0.022404846,-0.008133431,0.116295874,-0.037823893,0.015628938,0.05705405,-0.0474806,-0.0668978,0.051413726,0.03407228,0.014689178,-0.020569682,-0.09973508,-0.033713542,-0.054815467,0.0011716766,0.071881555,0.054692566,-0.003039277,-0.021226583,-0.020860458,-0.035670336,-0.011858547,-0.01719541,-0.06803745,0.018392676,-0.010203586,0.026242794,-0.11926039,-0.01409343,0.018609758,0.019154768,-0.06836808,0.047443055,-0.030974725,-0.039364237,0.016138872,-0.025451051,0.04297558,-0.092254356,-0.0394435,-0.097433716,-0.027745074,0.027216693,-0.0697292,0.04585222,-0.050718665,0.019947555,0.013145087,-0.036517385,0.063245855,-0.00040906147,-0.0016749437,0.069891445,0.0546527,0.04016804,-0.040780813,0.09490698,0.06515592,0.03607216,0.009353038,-0.12637357,-0.022018671,0.06610496,-0.06827765,0.08377349,0.053069044,-0.041039217,0.01823494,-0.03935296,0.024968898,-0.01636002,0.04652074,-0.071334794,-0.047877774,0.028126113,-0.036014654,-0.014485554,0.010305182,-0.07217688,-0.053374875,0.037110835,-0.015333581,0.009291231,-0.022469742,0.03362953,0.043439277,-0.057853103,-0.019912438,0.031913854,-0.015916679,-0.0044070357,0.01938846,0.07481221,-0.018069206,0.07699661,-0.14188646,-3.6478062e-34,0.075246416,0.04360638,-0.04146581,-0.021222895,-0.025553256,0.025671741,-0.07511481,-0.031302486,-0.06765962,-0.028945144,-0.09856069,-0.09558228,0.06453224,-0.059147377,-0.020455454,0.023750858,-0.033533514,-0.011877572,0.05635669,0.00055035343,-0.02782024,0.025154572,-0.13191229,0.029410176,0.0023774563,0.11969612,0.025827862,-0.012041261,0.0062383986,0.0059810816,-0.01898563,-0.08363607,-0.08716461,-0.010190721,0.075776726,0.03373074,-0.0940075,-0.051199276,-0.011518114,0.047598515,-0.0454807,-0.0038923244,0.006619037,0.020440714,0.06463223,-0.013139532,-0.124729514,0.097682156,0.08279601,0.073915,0.03780297,-0.048018936,0.1264829,0.027515167,-0.085113354,0.028782435,0.010962413,0.044988073,0.017707951,0.029147023,-0.023147058,0.010684438,-0.059066948,0.017863175,0.01713635,-0.03322027,-0.06000081,0.021515941,-0.036965817,0.120355316,-0.008304387,-0.04409594,4.5865087e-05,0.0750948,0.04676114,-0.05107917,0.007339049,0.0050996603,0.059427686,0.05964141,-0.005899102,-0.034840494,0.016381368,-0.058861915,-0.06480882,0.0072745048,-0.035857987,0.012694206,-0.004079732,0.020984901,0.06232483,-0.050011136,-0.0057337508,-0.005683712,0.019470459,-2.3035171e-33,0.08764444,-0.036832545,0.059084434,-0.06241103,0.007252,0.07123692,-0.051451452,-0.016084561,0.01583457,0.06427599,-0.02428523,-0.009802892,0.018385118,-0.016944887,0.03760821,-0.021938873,0.016012598,0.06743936,0.02190543,0.011729834,-0.10001894,0.022270542,-0.017932365,0.0037292505,0.012080716,-0.017408386,-0.0330736,0.031188246,0.01696058,0.070785016,-0.0010242133,-0.025254918,-0.054251466,-0.0015746854,0.045985464,0.062134374,-0.04748169,0.042932272,0.029011259,-0.009237769,-0.05660206,-0.037394844,0.08766138,0.07536607,0.07547213,0.07297517,-0.15101925,-0.0066933604,-0.07717865,-0.024320923,0.008423234,0.09425285,0.09062684,0.06031868,0.049603384,0.004513137,0.02670176,-0.029048417,-0.049835365,-0.05771488,0.0020557814,-0.029820649,-0.03274834,0.06591754,-0.03259984,0.051941577,-0.019151034,0.078397356,-0.010045339,-0.007810529,-0.015223678,0.010227511,-0.013118688,0.039601464,-0.06744874,0.03859496,-0.037657876,-0.041196898,0.005308785,-0.020836385,0.03315671,0.018945778,0.017852902,-0.05929494,-0.041360464,-0.064664066,0.010932198,0.106546946,0.045392513,0.008273244,-0.0010871212,0.04033884,-0.073629014,0.026239647,0.06302664,-3.0865706e-08,-0.024828674,-0.0776967,0.026627388,-0.054264598,0.007432932,-0.057047594,-0.016113903,0.010902588,0.043029748,-0.0054509966,-0.034847815,0.061901845,-0.0032512182,0.030359646,0.060320053,-0.012578531,0.0067267,0.029516371,-0.020216186,0.08203007,-0.05516833,0.04091022,-0.07896779,0.016055392,0.023146715,-0.041687317,0.02061663,-0.020868817,0.03359945,0.015398307,0.045097154,0.021388216,-0.02062766,-0.0087007275,-0.10807672,0.06908199,0.049757183,-0.10409432,-0.02254855,-0.00044968724,0.0058974666,-0.082362846,0.01461803,-0.012491267,0.012193158,-0.009130013,-0.015436208,-0.032945964,0.013772056,0.021897675,0.0037879103,-0.0048791072,-0.01423644,-0.04920709,-0.11734913,-0.0076917745,0.044385575,-0.071038306,0.011642314,-0.07524142,-0.058148105,0.044295,0.22163224,0.008954454 +1.14.14.57,"A cytochrome P-450 (heme-thiolate) protein. Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid [5].",384,1.0,0.015047696,-0.0521459,-0.03604572,-0.04928348,0.030072166,0.06441056,-0.056877594,0.067136824,-0.02324786,-0.0074958727,0.024096156,0.03710276,-0.03791767,0.0705479,0.0012774415,0.082127266,0.01903761,0.0010241632,0.022412205,-0.0856769,-0.057331096,-0.040925957,0.012865807,0.02498724,-0.037334565,-0.014052913,0.064753674,0.0350818,-0.098538555,-0.06512204,-0.06050369,-0.024078658,0.0826175,-0.063136145,-0.050777316,0.032688625,-0.08613481,0.0007706919,0.0414338,-0.049462713,0.0442035,-0.04861537,-0.055331778,0.0029870372,-0.032163512,-0.06395439,0.009852877,-0.026723504,0.051054418,0.024385177,-0.0532643,0.02295742,-0.034731384,0.04361817,-0.061267693,0.064466,-0.048180155,-0.04053677,0.03963781,-0.05530665,-0.0861594,0.027260559,0.014757646,-0.029593624,0.04197992,-0.019157836,0.04733819,-0.050391298,0.029496688,-0.03413609,-0.003605197,-0.073028065,-0.020599408,0.0076071555,-0.0838688,0.07296217,-0.03386451,-0.046892986,0.03993903,-0.046461355,-0.03038199,-0.0149409445,-0.06502966,0.119176544,0.12692164,-0.03306367,-0.06882589,0.014434269,-0.085246764,-0.0153689915,0.019128097,0.000968635,-0.03503878,-0.039634917,-0.034714505,-0.013427668,0.02925506,0.039605085,-0.051692482,-0.027547078,0.06777155,0.06355389,0.013416916,-0.10551585,-0.009827351,-0.0052866004,-0.014014543,0.052766744,0.074625336,-0.062373325,-0.0016880964,-0.05502359,0.011186729,-0.04839413,0.028002698,0.13706078,0.013105105,-0.03955696,-0.042782754,0.047161948,-0.011834926,0.029372154,0.043624572,-0.005017434,-0.024912855,0.015828427,-0.027156632,5.565325e-33,0.08999397,0.025343392,-0.032931022,0.04726145,0.007989966,0.042786352,-0.08318951,0.026589174,-0.012012734,-0.01609343,-0.01618179,-0.018366981,0.025031928,-0.029332545,-0.032529943,0.029570771,-0.031167902,0.0038977969,0.08657068,0.025387239,-0.08056757,0.038547497,-0.046609376,-0.039172065,0.025615169,0.049332898,-0.025645876,-0.018343728,-0.041259337,0.057390857,-0.034137063,-0.04044765,-0.06881468,-0.02173541,-0.006069174,0.011882908,-0.04217029,-0.01750864,-0.033034105,0.012282454,0.050646964,-0.03570657,0.010794338,-0.0010217031,0.048454486,-0.021136703,-0.06661107,0.03970792,-0.038393073,0.05163648,0.053026546,-0.11341066,0.07823186,0.027643098,-0.044505905,-0.03169074,0.027945332,0.013010511,-0.012887354,0.07207067,0.11826247,0.100849986,-0.09644939,0.07146496,0.04072293,-0.03621384,-0.060051072,-0.050239313,-0.07244625,0.043324012,-0.007840048,-0.027366562,0.049095556,0.019081768,-0.04367642,-0.03227877,-0.031531934,0.11381191,0.044852033,0.043563776,0.009256594,-0.020676082,-0.034543853,-0.018838907,-0.04283459,0.05122276,0.07671792,-0.043208428,-0.039009836,-0.040872645,0.028527968,-0.086220264,0.014041481,0.04154933,0.023570338,-5.7979918e-33,0.017670536,-0.08175026,0.06272332,-0.05650451,-0.04484123,0.0876646,0.07126236,-0.07526538,0.01818353,-0.038608316,0.10412385,-0.087311864,-0.011231435,-0.0035365832,0.060278315,0.034209695,-0.04580839,-0.0024588117,-0.012296327,0.01732105,-0.04942398,0.05746877,-0.01158133,0.124787204,0.07276323,0.059851434,0.0036320584,-0.024343586,0.082203485,0.057810865,-0.07092159,0.08237386,-0.0613589,-0.051179014,0.00047739208,0.008185095,-0.024402494,0.005658457,-0.016682645,0.039466046,-0.042179722,0.094895236,0.055631902,0.03794664,0.009315748,0.12410621,-0.028503845,-0.06584578,-0.019420633,-0.014304059,0.06766983,-0.03391811,-0.043217354,0.017202698,-0.004003901,0.072592765,-0.062418055,-0.0037640042,-0.02723259,-0.1270253,-0.095071174,0.03440564,-0.023225522,0.042846706,-0.03055,0.053106617,-0.0348152,-0.03770168,0.012180264,-0.045579232,0.0013040659,0.019857528,0.11314486,0.09292596,0.018981086,0.057611182,0.003606864,0.014973425,0.04273416,-0.031682856,-0.009252393,-0.004994771,-0.046321373,-0.046175033,0.016626097,-0.080987416,-0.102277465,0.11356713,0.045428324,-0.040207047,0.010148319,0.047901552,-0.083215,0.011719961,0.042591155,-3.986708e-08,0.027705913,-0.061286055,-0.004610422,0.019208515,0.035608724,0.017992493,0.027855992,-0.04361213,0.0748454,-0.0065368046,-0.04962525,0.09142969,-0.023725815,1.9525586e-07,-0.05122214,0.07029071,0.0046578725,0.010602801,0.04570103,0.019771148,-0.07177122,-0.0017038264,-0.0032579717,0.028961008,0.024681369,-0.07618449,0.040514495,-0.022436623,0.04556487,-0.02008749,0.04190094,-0.0018028913,-0.07167805,0.011609373,0.078683615,0.013754842,0.0069781975,-0.040729173,-0.021531075,0.09236404,0.0072389515,-0.032705616,-0.11882807,-0.0348795,0.026163062,-0.067685105,-0.0017503528,0.04104011,-0.05458616,-0.017747177,-0.07537937,-0.004201919,0.039297953,-0.075841255,-0.040640816,0.019873595,0.09425751,-0.0919356,-0.046832323,-0.06782038,0.05148479,0.057660766,0.14636225,-0.027731022 +1.14.14.58,"A cytochrome P-450 (heme-thiolate) protein isolated from the plants Arabidopsis thaliana (thale cress) and Zea mays (maize). It forms this C16 homoterpene in response to herbivore attack. In vitro some variants of the enzyme also convert (3S,6E)-nerolidol to (3E)-4,8-dimethylnona-1,3,7-triene (see EC 1.14.14.59, dimethylnonatriene synthase).",384,1.0,-0.07417478,0.0069090487,-0.03837428,-0.023107383,0.053724293,0.07885488,-0.048727706,0.078692876,0.05071734,0.034189485,0.07952536,-0.06265154,-0.049012978,-0.019579638,-0.0013157999,0.0036403027,-0.04021421,0.03389899,-0.0070682457,-0.07483676,-0.016956663,0.0694919,-0.0053022285,0.025442395,-0.050518084,-0.03277835,0.020924194,0.053810414,-0.014470856,-0.0387567,-0.05167492,0.0059827887,0.011164331,-0.021337915,0.004737759,0.06174389,-0.026709467,-0.12011397,0.05496969,-0.0050821356,0.07515504,0.00318263,-0.061820794,0.004689426,-0.11961063,-0.04575521,-0.061130412,0.028250294,0.018498903,-0.075629145,0.011956064,-0.031625494,-0.0884322,0.016800318,-0.017527834,-0.022534605,0.08845443,0.04058262,0.009225897,0.034426864,0.012956927,0.029854529,0.021943951,0.000829896,-0.04074166,-0.03103203,-0.038227186,0.04023767,-0.0035834683,-0.069428936,-0.081099205,-0.10946965,-0.016483387,-0.009957223,-0.07003051,0.101660855,-0.05046625,0.023332775,0.01447906,-0.053753328,0.028061396,0.01642164,0.02253578,0.114613116,0.06078756,-0.0046631787,-0.07174754,0.08475854,0.037816986,-0.0030851853,0.037774313,0.05301667,-0.019557666,0.009266666,-0.109104335,0.11610535,0.037784487,-0.050171584,-0.03405448,-0.02244915,0.10950801,0.056995776,-0.037271284,-0.09455283,-0.050492965,0.08482839,-0.021365043,-0.0131104635,0.035671845,-0.039092906,-0.074763335,-0.019055407,0.0013962283,-0.013180556,-0.04318961,0.013645564,-0.030796539,-0.05097353,0.031722445,-0.043214504,-0.024026645,-0.016518496,0.026642915,-0.030852752,-0.02484802,-0.0268238,-0.092796765,2.9465309e-33,0.04608518,0.10011421,-0.044245474,0.0051353234,-0.030042706,-0.0278992,-0.0380401,0.1129525,-0.07270099,-0.045695245,-0.065382384,-0.11918103,0.010478591,-0.055363785,-0.020444814,0.037480045,-0.06722635,0.030532515,0.033732,-0.0054606516,-0.07575089,-0.03452453,-0.05418593,-0.0040904577,0.039011363,0.098922685,-0.03823939,-0.06709849,0.028544502,-0.020694563,-0.015823586,-0.063807346,-0.002128948,-0.035234723,0.06318022,-0.022168884,-0.002632194,-0.026802458,-0.13529493,0.04239172,-0.039316468,0.04265849,0.04318133,-0.065941416,0.05835881,0.035762377,-0.095260374,0.040053446,0.06061091,0.014700261,0.029243201,-0.062344085,0.10893251,0.025116296,-0.08397575,0.05863827,0.002344006,0.018174477,0.008538681,0.002112634,0.04466077,0.076658204,-0.044650782,0.024720004,0.025431,0.07549962,-0.10849847,-0.07102397,-0.011971594,0.1499694,-0.030593308,-0.048049793,0.02054097,-0.048572615,0.0761558,-0.023777334,0.022815995,0.01988919,0.02666373,0.038078465,0.047211144,-0.052911166,0.04059778,-0.03098012,-0.027669508,-0.05633065,0.02005757,-0.002795135,0.027823793,0.0654646,0.12330484,-0.07884436,-0.008753327,-0.0036711881,-0.05948282,-2.5391235e-33,0.045211148,0.020995114,0.05010129,-0.076425865,-0.023211008,0.057990767,-0.01802141,-0.021364883,-0.01608874,-0.028708316,0.092511214,-0.020115465,0.020800043,-0.04569715,0.037545495,0.014222386,0.007194123,0.021788938,0.030223917,0.04054677,-0.011080253,-0.04006884,-0.0018591656,0.04628432,0.025002861,0.019445112,0.054376345,0.015243061,0.057677213,-0.025645493,0.015339206,-0.0244038,-0.03016638,-0.026347352,-0.027740588,0.037212707,-0.007534978,0.02909467,0.010349545,0.06798478,-0.030998899,0.06593834,0.019870866,0.0541953,-0.0097625,0.07784265,-0.059364285,-0.0076844627,-0.015189342,0.035171468,0.07986858,0.0049872007,-0.052797098,0.037369467,0.022796128,-0.024804387,0.051157,0.004519898,-0.028063137,-0.049732722,-0.0019020841,-0.01745645,-0.063241914,0.07890185,0.044479486,0.06365267,-0.081644855,0.06256319,-0.010056246,0.033796377,0.048552964,0.059397023,0.036099635,0.030157737,-0.04627892,-0.027986567,0.029169923,-0.07306877,-0.021492004,0.0045540472,0.054878473,0.035638463,0.0025447188,-0.07629343,-0.04145706,-0.07264006,-0.035667874,0.14755268,0.05772458,-0.00962884,-0.015127924,0.062063467,-0.015771242,0.055427823,0.091902554,-4.6043855e-08,-0.03849861,-0.087255105,0.0061698244,-0.04124651,0.014523526,-0.018523829,0.029061038,-0.038744513,0.074449524,0.036459908,0.022285873,0.024927218,-0.00026426735,0.028669875,0.03105453,0.0036400836,0.013857423,0.03377043,0.026233628,0.052881762,-0.019583695,0.04333582,-0.08565036,-0.029813817,0.07497103,-0.102518536,-0.017916044,-0.0021849498,0.055930294,0.012067715,0.024878353,0.034394875,-0.009489233,-0.010406308,-0.009854623,0.059661064,-0.028791409,-0.049044605,-0.029791532,-0.025925586,-0.015078602,0.005337204,-0.06122359,-0.02222173,0.028700633,-0.052433696,0.044024196,0.030612301,0.022050165,0.0076490105,-0.0405035,0.016204463,0.027371358,-0.128532,-0.056423217,-0.0667131,0.041966844,-0.0037434192,-0.04291227,-0.11765859,0.006217281,-0.024235496,0.21085407,0.030144315 +1.14.14.59,"A cytochrome P-450 (heme-thiolate) protein isolated from the plants Arabidopsis thaliana (thale cress) and Zea mays (maize). It forms this C11 homoterpene in response to herbivore attack. In vitro the enzyme also converts (6E,10E)-geranyllinalool to (3E,7E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene (see EC 1.14.14.58, trimethyltridecatetraene synthase).",384,0.99999994,-0.06767996,0.028700512,-0.03045518,-0.022251992,0.057243187,0.07106287,-0.033488378,0.08010073,0.057428483,0.052799463,0.06499803,-0.037925787,-0.017465197,-0.013913517,-0.044917032,0.002617945,-0.023219306,0.037964858,0.0059293592,-0.07807275,-0.02816025,0.07480923,0.002816149,0.029179486,-0.024508247,-0.06449833,0.0073078494,0.040066842,-0.020832872,-0.034648504,-0.04578813,-0.009408117,0.024117133,-0.0060637156,-0.009798317,0.0712944,-0.031835116,-0.13006186,0.03759847,-0.034872785,0.065114945,-0.010877047,-0.07312767,-0.0030648059,-0.099762574,-0.039539717,-0.04892458,0.018093538,-0.0017440363,-0.07480908,0.017937683,-0.045667738,-0.097925335,0.006158629,-0.018445568,-0.010298056,0.061106186,0.024950655,0.026068715,0.03289373,0.009764992,0.009834989,-0.00028624752,-0.014831715,-0.014823042,-0.0435315,-0.04003128,0.043853965,-0.0016611255,-0.0792034,-0.06389875,-0.094490536,-0.040883906,-0.003900705,-0.0895229,0.1131456,-0.06908116,0.034758728,0.0032940488,-0.026707534,0.043886617,0.008991988,0.017766234,0.09632724,0.07084345,-0.018348118,-0.07925976,0.10177724,0.043111466,-0.006847506,0.045585074,0.038728908,-0.007161432,0.018709214,-0.1039324,0.094792865,0.042784747,-0.049184497,-0.0131212985,-0.01789786,0.09516899,0.03456267,-0.013208018,-0.07963247,-0.08861439,0.08066582,-0.018211832,-0.024942752,0.039297808,-0.04805475,-0.08276278,-0.023803987,-0.017573217,-0.02871132,-0.041090723,0.014635918,-0.0021441337,-0.04610254,0.046511415,-0.023979962,-0.023735303,-0.0023243567,0.025499266,0.00030254695,-0.006580696,0.0109267635,-0.09673595,3.1385126e-33,0.05846522,0.081605576,-0.037680615,0.03635507,-0.021055289,-0.006087951,-0.042163778,0.10802454,-0.059565876,-0.050388962,-0.052039027,-0.11594771,0.025941962,-0.04810632,-0.027022302,0.041004926,-0.048610445,0.008249722,0.03801102,0.0007722664,-0.08559221,-0.020689571,-0.05827889,-0.007759815,0.039496962,0.07696695,-0.06319318,-0.06616001,0.025853798,-0.011763743,-0.016624643,-0.07067219,-0.047261514,-0.02843731,0.06674708,-0.008777921,0.013208753,-0.01162713,-0.13609257,0.018888595,-0.039659686,0.03413992,0.025810657,-0.093770094,0.07745565,0.025824094,-0.08964678,0.036792498,0.02671687,0.045350123,0.04881375,-0.06518468,0.08543664,0.032124102,-0.09723656,0.043588955,0.026098695,0.0017004007,0.00060592033,0.027986823,0.06237952,0.08740612,-0.052476406,0.010285339,0.02548426,0.065777294,-0.10280722,-0.043573465,-0.025451684,0.17802732,-0.042545147,-0.04155917,0.047117427,-0.04810905,0.06543653,0.0014686051,0.0031935652,0.03707517,0.04137298,0.035668727,0.052734405,-0.04697025,0.03464012,-0.02898256,-0.022408213,-0.04021911,0.01170533,-0.0104865385,0.02567911,0.06942705,0.115100406,-0.07541161,-0.012917698,0.034075163,-0.04723259,-3.060005e-33,0.055024177,0.0078048175,0.05246358,-0.067466974,-0.04001337,0.055342,-0.030549731,-0.03196789,-0.007017514,-0.030948067,0.10865007,-0.019599246,0.025521476,-0.012524273,0.025434587,-0.032452654,0.0049892575,0.046923067,0.0022925076,0.03148409,-0.04442685,-0.038401276,0.024719741,0.022945775,0.022956535,0.025378924,0.055339463,0.03164021,0.055617467,-0.011336805,-0.007607318,-0.026044296,-0.03291358,-0.027706418,-0.03940736,0.028026005,-0.018342948,0.025448117,0.03582062,0.055241637,-0.030309038,0.07671943,0.051233847,0.041298006,-0.013690985,0.08276258,-0.04952386,-0.0008521181,-0.021396086,0.022009606,0.082921214,0.025682826,-0.0489691,0.05042915,0.010618781,-0.025931088,0.051006306,0.010092283,-0.03931026,-0.04442128,0.004209938,-0.0021720212,-0.06858431,0.058042455,0.047193825,0.044949107,-0.07304513,0.069917135,0.008567077,0.05035207,0.023352401,0.06840914,0.043755114,0.016592655,-0.02104027,-0.007933686,0.016425066,-0.06876858,-0.00810492,-0.0085047735,0.030252991,0.015585209,-0.012343313,-0.08824734,-0.013264296,-0.08171805,-0.073639214,0.15166143,0.08787558,-0.025805125,0.003547517,0.06891227,-0.014773173,0.059126996,0.084311575,-4.732915e-08,-0.050100792,-0.087835684,-0.035675667,-0.044342294,0.03029975,-0.004005353,0.022770446,-0.051666502,0.077189386,0.03465139,0.008143419,0.04050296,-0.02076978,0.037647307,0.021215161,0.0065573663,0.00574361,0.02069087,0.04201545,0.056030203,-0.032933168,0.02757194,-0.076022945,-0.013502412,0.05813577,-0.13920777,-0.015283317,0.030464116,0.08742756,0.004379145,0.018925916,0.04332917,-0.01943029,-0.017552668,-0.021400781,0.062501214,-0.00449925,-0.03626472,-0.022941235,-0.016208638,-0.003370106,-0.00028507024,-0.06184791,-0.03574951,0.006447965,-0.03731672,0.057821047,0.036968652,-0.0100112455,-0.015310457,-0.031041343,0.024571983,0.019593772,-0.11817718,-0.06639842,-0.06253882,0.056680646,-0.020507118,-0.029107606,-0.13780975,0.003322881,-0.03102575,0.18858187,0.038410872 +1.14.14.60,"A cytochrome P-450 (heme-thiolate) protein isolated from the plants Salvia pomifera (apple sage) and Salvia miltiorrhiza (danshen). 11-Hydroxyferruginol is a precursor of carnosic acid, a potent antioxidant.",384,1.0,-0.06169215,0.021077072,-0.04689901,-0.0059750406,0.0891222,0.13486694,-0.01526995,0.09664574,0.032385986,-0.0054895915,0.053246424,0.02056088,-0.062403914,-0.027931241,-0.018833147,0.06818219,-0.02445681,0.009757925,0.001874022,-0.027209189,0.048045333,0.047373515,-0.013166275,0.054389544,0.033272017,0.0029485475,0.025369052,0.0795583,-0.046904244,-0.033381253,0.024217963,-0.04757254,0.1280584,-0.04066589,0.012430026,0.057461467,0.026344651,-0.10625737,0.011457544,-0.040298317,0.036070142,-0.007001004,-0.1066542,0.05467359,0.022547392,-0.038323265,0.01959134,0.018707728,0.08326259,-0.05150788,-0.05548766,-0.07759994,-0.033031363,0.009246609,-0.054657236,0.019822026,-0.005892674,-0.024149489,0.018242018,0.012587192,-0.0039814957,0.009340357,-0.015229681,-0.034755316,-0.002918999,-0.03437677,-0.023573449,-0.02144153,0.030549053,-0.07841214,-0.021065332,-0.06374755,0.01195012,0.045939565,-0.06808399,0.050250586,-0.06272383,-0.003312402,-0.024960442,-0.03050499,0.058798976,0.048649926,-0.05295043,0.13172258,0.04344679,-0.009206559,-0.005812404,0.041925825,-0.009705044,-0.028613746,-0.025035784,0.0007934991,-0.011158975,-0.011017136,-0.0807592,0.050652124,0.037685815,-0.051989738,0.0060444665,0.020129332,0.07556529,0.07829098,0.012571339,-0.1548992,-0.043397244,0.097400345,-0.06517231,0.01797668,0.0363287,-0.044773586,-0.032556858,-0.007527832,-0.062403318,-0.04788898,-0.029149823,0.050925173,-0.008896191,-0.016340293,-0.05262393,-0.059884418,0.005382678,-0.017221576,0.0297603,0.008650391,-0.0019310655,0.008668221,-0.0759235,3.3623877e-33,0.06938315,0.025837572,0.010801791,0.030429903,-0.017,-0.0378671,-0.060695387,0.08455047,0.006146775,-0.053370815,-0.078633286,-0.09233539,0.03306241,-0.059441008,0.006353932,-0.027540144,-0.07035265,-0.0069646793,0.11611582,0.03144721,-0.08675487,-0.026620956,-0.034816463,-0.059800968,-0.021873508,0.073703095,0.006679816,-0.052389715,0.09938327,0.022520885,-0.009102586,-0.02805445,-0.0340292,-0.05359952,0.06207288,-0.04355336,-0.012974243,-0.053773765,-0.00047089605,0.051580988,-0.024154207,0.019051412,0.058080833,-0.047884647,0.05973654,-0.04073635,-0.10623709,0.018247368,0.041337933,0.021247517,0.009404791,-0.06813961,0.08727305,0.048754115,-0.08599879,-0.008445821,-0.023362301,0.036271732,-0.039288744,0.05478188,0.067858405,0.08247775,-0.04074625,0.027574128,-0.020022288,0.053407352,-0.07786889,0.0034460584,0.018284768,0.13436295,0.0061102402,0.0052979025,0.016840426,-0.0036530446,-0.0062985294,-0.05712473,-0.02210759,0.106594704,0.057987515,0.023944328,-0.023077725,-0.0036337685,-0.0320109,0.045142096,-0.0306021,0.025358131,0.033646874,0.036502153,-0.029506836,0.03335121,0.043225996,-0.05790467,0.01747857,0.00036687995,-0.08753511,-2.8327875e-33,0.079168126,-0.07345754,0.005915058,-0.06770038,-0.04321966,0.08074538,-0.024624221,-0.011224271,-0.07345423,0.023339216,0.07511184,-0.062959485,0.037980083,-0.05438602,0.032985378,0.028678376,-0.04709144,0.033949837,-0.089425944,0.052917395,-0.025978306,-0.0016024003,0.05233847,0.023017462,0.06016836,0.010178332,0.0024420426,0.029049503,0.060021754,0.075602755,0.01951974,0.016749533,-0.096976705,-0.10410604,-0.032736562,0.027687611,-0.036507398,-0.029186623,0.05168708,0.059155945,-0.010469811,0.08829428,0.0060132015,0.028069006,0.049274255,0.12380201,-0.067239396,0.015604079,-0.025266621,-0.019977437,0.07733097,-0.009564318,-0.015689949,0.021772929,-0.019688912,-0.020962108,-0.035411004,0.019113488,-0.047946215,-0.055262145,-0.029468145,-0.033017896,-0.04103582,0.016949825,0.034068994,0.049383327,-0.010366612,0.07045572,-0.0027858713,0.0035873768,0.05825107,0.023499692,0.044092752,0.09984729,-0.010923879,0.034167793,0.016125206,-0.0338534,0.0075832577,0.033649683,0.010218087,0.015247245,-0.05004901,-0.04677212,-0.0101809455,-0.04718079,-0.04724942,0.087499306,0.015155336,0.030610966,-0.014856506,0.0693806,-0.058590904,0.06539215,0.062862754,-3.4396336e-08,0.02570079,-0.10190379,0.00086909917,-0.04013405,-0.019324593,-0.020594968,-0.015084447,0.028333617,0.04627142,-0.01297012,0.022638472,0.06518584,-0.048109114,-0.0047958274,-0.052518003,0.011998479,0.10202529,0.086439796,0.022565696,0.044819552,-0.04091027,0.053014807,-0.055286165,0.030005053,0.020292118,-0.13234209,0.039318558,-0.045029324,0.051143873,-0.009513313,0.035967875,0.017578978,-0.049358044,-0.038688563,0.020515082,0.07218346,-0.030350588,-0.027749734,-0.014663653,-0.022976361,-0.010374301,-0.047735702,-0.1194676,-0.025134055,0.038292218,-0.033531938,0.03504924,0.04831449,-0.046993602,-0.034498047,-0.015406816,-0.002998817,0.028967682,-0.114640206,-0.14703877,-0.0043646097,0.037455548,-0.09448327,-0.03638233,-0.11651059,0.020570721,0.023344796,0.1729882,0.04529449 +1.14.14.61,"A cytochrome P-450 (heme-thiolate) protein isolated from the plants Salvia pomifera (apple sage), S. miltiorrhiza (red sage), S. fruticosa (Greek sage) and Rosmarinus officinalis (Rosemary).",384,1.0,-0.05571864,-0.0172191,-0.08476427,0.026427666,0.11117302,0.10500993,-0.020306267,0.03080468,0.058291394,-0.047992647,0.06625181,0.022280416,-0.073741846,-0.01600005,-0.0019123829,0.058396887,-0.03235097,-0.013711373,-0.015145105,-0.013646361,0.045966666,0.04469424,0.0029593906,0.056600183,0.06276321,-0.034488663,0.002669347,0.059867743,-0.075661965,-0.07618345,0.039369725,-0.04859756,0.098736905,-0.050807357,0.005365307,0.07184753,0.028099297,-0.06469283,0.03235358,-0.062310867,0.011135161,-0.0003382527,-0.059655566,0.059973374,-0.013775268,-0.015420643,0.029045817,0.016947035,0.07326512,-0.043756034,-0.054826185,-0.081101805,-0.051257186,0.060179554,-0.03345495,0.018907389,0.030420054,-0.031374242,0.007085649,0.02806451,0.0014782519,0.0129161915,-0.013943227,-0.029933224,-0.070418105,-0.01528227,-0.044840407,-0.036993973,0.050623175,-0.08824576,-0.02452771,-0.076397605,-0.024642846,0.061511464,-0.057931114,0.102515645,-0.06448296,0.016779741,-0.016223969,-0.01870057,0.023333685,0.07095757,-0.010602258,0.114050865,0.04985471,-0.010276562,-0.010122373,0.08020776,-0.016315093,-0.03780698,0.0019784188,0.035509117,-0.015829336,-0.018748814,-0.064912364,0.05220514,0.028059242,-0.035969783,-0.0042750863,0.04358017,0.0786794,0.036542352,0.019411348,-0.114529714,-0.043784026,0.06747189,-0.08876155,0.009099753,0.02909694,-0.057226766,-0.0109398,-0.008183955,-0.029843494,-0.0512393,0.02071351,0.035291355,0.042295653,-0.01066588,-0.0718102,-0.06436891,-0.005278602,0.028640542,0.07336293,0.027340444,0.013409416,0.007271089,-0.103376135,3.4412292e-33,0.06814542,-0.0015520946,0.008960088,0.0349,-0.040131472,-0.042895537,-0.030408578,0.10739436,0.029640043,-0.030182341,-0.05736191,-0.10109628,0.026666751,-0.054574974,-0.01141935,-0.011406156,0.027257286,-0.016102936,0.09065395,0.013407544,-0.10030224,0.02360695,-0.02914702,-0.0315457,-0.0372119,0.0707983,0.016400043,-0.06896135,0.08511225,0.0017252342,0.019606085,-0.06887262,-0.03914668,-0.038595833,0.07481039,-0.022155894,-0.037713762,-0.047216073,-0.03872299,0.05352118,-0.028718319,0.04827469,0.05815899,-0.013752049,0.07019153,-0.00892974,-0.1322507,-0.0020225453,0.02926491,0.0151017355,-0.043299917,-0.031134237,0.116471425,0.05968567,-0.096439704,-0.0110645145,0.012294307,0.060676254,-0.020479308,0.02904249,0.008858443,0.057345398,-0.05725238,0.011443842,-0.01816896,0.05741467,-0.06432136,0.026251528,-0.038981047,0.15448534,-0.0019026875,0.041685656,-0.012905423,-0.056162197,-0.01038102,-0.055299852,-0.022537041,0.04599178,0.026843276,0.025329482,-0.033416163,0.013187528,-0.017106298,0.035874225,-0.061461847,-0.010673014,0.0034386052,0.035717618,-0.01386968,0.026740812,0.033532284,0.0010270338,-0.009981075,-0.019607313,-0.06846939,-2.2066073e-33,0.07276066,-0.060170345,0.0023324552,-0.05331316,-0.054239582,0.10116928,-0.048924927,0.036544133,-0.072516926,-0.010704262,0.062732555,-0.07387729,-0.0009983256,-0.047309756,0.0117989415,0.014536535,-0.047639035,0.064299636,-0.0088177975,0.08377822,-0.10133018,-0.0076272534,0.05693251,-0.013610464,0.06502711,0.015580743,0.02888602,0.02981455,0.037153713,0.008480082,0.052035823,0.0010445748,-0.1017589,-0.08749095,-0.062481083,0.015413192,-0.03375171,-0.034439437,0.03820995,0.081487834,0.036733232,0.09297164,0.013569483,0.020225365,0.04363713,0.101622425,-0.10019736,0.04256497,-0.039536126,-0.0012339012,0.087645054,-0.03524622,-0.014556043,0.013187376,-0.000798169,-0.031668365,0.004663178,0.041684918,-0.029447304,-0.03275791,-0.013459855,-0.018091928,-0.058777317,0.04890159,0.016985921,0.054753896,-0.011295086,0.09086942,-0.06182095,0.0521775,0.06567233,0.0025663015,0.037685316,0.09510507,0.025552323,0.05838228,0.03559716,-0.021883154,0.01284615,0.035712678,0.04898552,0.016130693,-0.030759953,-0.05291971,0.033037607,-0.03802136,-0.030512417,0.062286016,0.012394909,-0.00037713826,-0.010119239,0.08462304,-0.021356562,0.03968535,0.09153183,-3.3620182e-08,0.03476652,-0.091707736,-0.024646312,-0.035193402,0.004729134,-0.0035927354,0.0038074518,0.015174918,0.018035302,0.041363567,0.008612736,0.035346925,-0.031173976,-0.01613292,-0.046310708,0.010375818,0.091541,0.06936436,0.044166334,0.042698275,-0.0119572105,0.05420574,-0.059423026,0.014149689,0.013341196,-0.14205381,0.027024765,-0.00052325835,0.06768631,0.005345324,0.048171777,0.018884925,-0.037744664,-0.040935975,0.039421257,0.05764508,-0.075663015,-0.062492315,-0.005036626,0.0150968395,-0.048359156,-0.048450734,-0.07736448,-0.06728224,0.007552023,-0.08319938,0.026142953,0.04678311,-0.042879924,-0.024213864,-0.018275991,-0.028608942,0.06328528,-0.086067714,-0.13856278,-0.05067181,0.07461695,-0.10052481,-0.055364642,-0.115183175,0.015691372,-0.0005359923,0.123446845,0.043826595 +1.14.14.62,A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia pomifera (apple sage).,384,1.0,-0.032612495,0.018032826,-0.029352987,0.00782371,0.096503764,0.099124186,0.009707373,0.034414638,0.030708449,-0.021013247,0.061956357,0.015067767,-0.06983364,-0.030639654,0.02971842,0.060338475,-0.017853202,-0.029100964,0.017487552,-0.025578506,0.04827304,0.033915374,-0.022893403,0.037533794,0.045320306,-0.008347568,0.008230515,0.077416524,-0.05936365,-0.09272042,0.0097386725,-0.041868076,0.104539394,-0.021316888,-0.0011496545,0.05630607,0.03427451,-0.10347015,0.009640001,-0.07121599,0.051537782,0.035206076,-0.10028282,0.08695741,0.003372842,-0.023431776,0.03945883,-0.0024444987,0.073784694,-0.042133894,-0.046447672,-0.0864883,-0.007246337,0.017700624,-0.03928742,0.02225058,0.03448111,-0.005234132,0.042372443,0.019320175,-0.006355564,0.030640997,-0.019761318,-0.048874423,-0.015172924,-0.042607855,-0.034312595,-0.042480126,0.035260428,-0.09202623,-0.018381646,-0.0689127,0.0012039496,0.045831192,-0.06474632,0.089875735,-0.06405535,0.01570123,-0.03612252,0.012859989,0.021440258,0.08448707,-0.022646239,0.106207035,0.022970278,-0.00563596,-0.014886091,0.062189177,-0.030685386,-0.057857428,-0.010326024,0.008522588,-0.019186871,-0.010232343,-0.058405947,0.06102432,0.02388561,-0.04219271,-0.000872003,0.028276272,0.08555848,0.06256441,0.016400497,-0.107022434,-0.012085487,0.06716656,-0.08190622,0.0025945175,0.024979424,-0.051644426,-0.019786352,-0.011419516,-0.006460247,-0.03101043,0.01434446,0.034256283,-0.01163562,0.012810599,-0.07307711,-0.04027128,0.007118096,0.02867799,0.059543975,0.02285034,-0.020397417,0.0058270716,-0.0757391,7.1799585e-34,0.0601395,0.011076242,0.01348981,0.01506382,-0.027969241,-0.072293326,-0.032631617,0.10481456,0.030442238,-0.028365903,-0.054319322,-0.12488331,0.033171184,-0.062468313,-0.024119675,-0.024411194,-0.0089545855,-0.0014120697,0.09604149,0.019247303,-0.13167873,-0.017807191,-0.037879817,-0.040087402,-0.04744979,0.08269382,0.019741995,-0.06240185,0.089590386,-0.001990561,0.005003288,-0.037114188,-0.021092659,-0.05657989,0.065923624,-0.061860234,0.016408818,-0.02869651,-0.038552683,0.051900633,-0.02878972,0.02564927,0.06018918,-0.009625814,0.076212555,-0.023655903,-0.11683289,0.0103939595,0.02365336,0.008928354,-0.045972653,-0.048649177,0.102443956,0.07472285,-0.08962768,0.005668693,0.016111696,0.03908456,-0.028553376,0.031215811,0.03428661,0.0556031,-0.057756267,0.017975338,-0.025358554,0.06956351,-0.07708423,-0.006999856,-0.0026481415,0.15968001,0.005531884,0.031178648,-0.012566234,-0.049512167,-0.02603116,-0.06578181,-0.029855186,0.079694845,0.05615703,0.014188439,-0.024026034,0.010763827,-0.025952088,0.043383013,-0.04616133,-0.0074814535,0.02780085,0.054241218,-0.027944908,0.046085592,0.049252477,0.009430222,-0.009831561,-0.033249076,-0.059048217,3.0647468e-34,0.08387951,-0.04762516,-0.0054483716,-0.06354406,-0.038182743,0.08572958,-0.026963336,0.013407353,-0.075264074,-0.0053724446,0.047710013,-0.07868949,0.011958845,-0.055509903,-0.010756443,0.046094187,-0.06915445,0.07432536,-0.04503084,0.089920945,-0.09232542,-0.023611853,0.068468876,-0.0047091553,0.04904633,0.026366238,0.019810185,0.017252445,0.08486112,0.030463098,0.047149714,0.018582981,-0.107472636,-0.091407485,-0.0470157,-0.0075278394,-0.010241268,-0.006205536,0.045494195,0.0671791,0.005821047,0.10210492,0.006544465,-0.0026245855,0.06025118,0.13911417,-0.061758637,0.02075133,-0.057481583,-0.017204642,0.096481085,-0.021992346,-0.03453421,0.02271107,-0.034537427,-0.024965268,-0.014519231,0.02282935,-0.03172302,-0.059454218,-0.015726151,-0.018523542,-0.031179473,0.05147395,0.010080796,0.053281557,0.013239636,0.08594231,-0.061432313,0.03386238,0.030882785,0.0105660325,0.05577663,0.080298044,0.011722006,0.06443178,0.017094761,-0.005757629,0.042868007,0.04033187,0.022267424,0.04194374,-0.053773277,-0.05772207,0.029470261,-0.0070826826,-0.05010458,0.078697495,0.028955467,0.017043453,-0.040542487,0.06690665,-0.06015314,0.043216106,0.078558445,-2.2505604e-08,0.039128516,-0.111151375,-0.02800075,-0.023216922,0.0007858024,0.015812054,-0.015100069,0.02928392,0.036631566,0.017672947,0.0071029975,0.021979526,-0.054134358,0.010706873,-0.05212495,0.011350994,0.113209024,0.06587226,0.05126501,0.031423412,-0.037849344,0.061212044,-0.021105628,0.02592649,0.028193103,-0.11496938,0.033448875,0.022681653,0.05314817,-5.8191687e-05,0.03490199,0.029823713,-0.06563431,-0.04420576,0.06182355,0.052949417,-0.03520743,-0.0498184,-8.794199e-05,0.016134819,-0.051278636,-0.044554427,-0.086777925,-0.06552845,0.01861518,-0.07197103,0.046587616,0.036171053,-0.04574909,-0.03071937,-0.016141666,-0.030103503,0.047066696,-0.080951296,-0.14443102,-0.040168718,0.057613272,-0.121614516,-0.05385996,-0.10654678,0.034545388,0.005551435,0.109864555,0.013925737 +1.14.14.63,A cytochrome P-450 (heme-thiolate) protein isolated from the plant Platycodon grandiflorus (baloon flower). The enzyme is also able to oxidize oleanolic acid to cochalic acid.,384,0.99999994,-0.09809743,0.01610856,-0.049699657,-0.039757587,0.07142624,0.100841425,-0.029979546,0.100639485,-0.0009204069,-0.017484408,0.04760074,-0.028896702,-0.07863211,-0.0075474763,-0.0060677384,0.040053003,-0.020293742,0.044894163,0.015613184,-0.065294184,0.04047378,0.07498083,0.005253236,0.03920754,0.0013987762,0.028192706,-0.0004610162,0.061717395,-0.0013013369,-0.05636068,-0.044809714,-0.027426425,0.054552313,0.008321981,0.026304603,0.05950058,-0.02529773,-0.12038247,0.022025762,-0.027353173,0.076347016,0.036095604,-0.09019175,-0.018159436,-0.04801518,0.012049617,0.03149582,-0.023932854,0.030283807,-0.006253408,0.031047398,-0.020947084,-0.08403893,0.018697266,-0.034366243,0.0066105686,-0.0022334312,0.021589117,-0.017317329,0.003120728,-0.00042717493,0.084667616,0.009238871,0.02466342,-0.027814811,-0.041170195,-0.0739836,0.020280413,0.059874743,-0.11490764,0.034408655,-0.067486554,-0.016204907,-0.00036032475,-0.08656047,0.06763839,-0.032929678,-0.008479321,0.014554376,-0.0042458028,0.017647898,-0.008913028,-0.037833527,0.13097605,0.03426275,-0.025948107,-0.0067063207,0.060448304,-0.05603496,-0.0644203,0.05630814,0.015650237,-0.031967837,0.0056705074,-0.06246509,0.04952553,0.039963175,-0.05889698,-0.058379006,0.0034549283,0.050714683,0.06554617,0.058601096,-0.13263151,-0.068855375,0.015150239,-0.0050262916,0.02620267,0.068895414,-0.056829024,-0.05643242,-0.011726844,0.011062761,-0.025460754,-0.04104312,0.06675368,-0.019165777,-0.06342486,-0.04068961,-0.04774928,-0.008410857,-0.04053726,0.028146246,0.05071402,-0.049203753,-0.0039650337,-0.11745058,3.1925655e-33,0.076354355,0.019559318,0.04829839,0.009319225,-0.03521082,-0.008841619,-0.06911254,0.038817007,-0.021265361,-0.020082299,-0.07024974,-0.07587373,0.02951988,0.0077439807,-0.026890343,-0.027375245,-0.045236465,0.019026512,0.12398354,0.03339654,-0.050924525,0.0396748,-0.019019837,-0.027649894,0.036426645,0.079313554,-0.041378718,-0.07403442,0.068237595,0.04274338,-0.020753065,-0.09966891,-0.038836278,0.010033145,0.033437725,-0.030878454,-0.057417538,-0.08316737,-0.05126311,0.052634146,0.0005279756,-0.041437495,0.027596842,-0.052075747,0.048587933,-0.03841081,-0.108096905,0.056923665,0.029644875,0.04108315,0.026051464,-0.07268238,0.047381092,0.07055775,-0.079313435,0.007575702,-0.034033187,0.01775759,0.029925743,0.0438731,0.101632446,0.08721682,-0.06465008,0.042011444,0.06408432,0.035847224,-0.12471161,-0.01103581,-0.033697747,0.103868455,-0.033631578,-0.07123912,0.009900448,-0.046932686,0.054002352,-0.032382112,0.057925317,0.07492874,0.06863143,0.06448586,0.041652814,-0.053740762,0.0006040982,-0.059350476,-0.07690396,-0.0045734076,0.045286205,0.012916563,-0.024193572,0.06506839,0.04640652,-0.06664151,0.011523892,0.009640371,-0.030927442,-4.0827075e-33,0.08106854,-0.07416906,0.046488505,-0.08975338,-0.031736556,0.054202918,-0.01947331,-0.03753585,-0.020609029,0.01566019,0.07738759,-0.055767074,0.0395639,-0.052569855,0.031155111,0.029070389,-0.036168013,0.075127184,-0.003189576,0.06465624,-0.038932767,0.0056420695,0.047403503,-0.010309835,0.041187037,0.03303244,-0.025757184,-0.000977237,0.04589325,0.010485046,-0.062755965,0.030156665,-0.07813786,-0.060773123,-0.035846185,-0.0064223795,0.013100102,-0.024894422,0.036704615,0.066616,-0.039696407,0.08751964,0.006947514,0.029777309,0.0822803,0.075652696,-0.07461471,-0.058179345,-0.023655407,-0.0036222273,0.055304307,0.008510372,-0.038418546,0.02875492,0.03450242,-0.0154463835,-0.026445549,0.04128307,-0.064510584,-0.060689397,-0.0072539616,-0.104718976,-0.06721178,0.04749148,0.03384686,0.09987902,-0.035276044,0.057027925,-0.026083868,0.019487942,0.016859332,0.00875145,0.06379359,0.04824399,0.018406888,0.005965495,-0.014970392,-0.05591861,0.008305282,-0.018083205,0.0109135,0.004008079,-0.030490598,-0.08506757,0.021046508,-0.058036834,-0.06963384,0.12728788,0.02192669,-0.029806795,-0.079380915,0.06408771,-0.029609965,0.09206454,0.11465235,-3.69433e-08,-0.033710685,-0.064601324,0.033695117,-0.017571544,0.0016209539,-0.020001633,0.00904328,-0.034893665,0.035324853,-0.02904335,0.0039876425,0.05284459,-0.029673064,-0.06262648,0.011264708,0.03805583,0.028538408,0.014488972,0.046534993,0.030658113,-0.032938786,0.02714338,-0.03334152,0.0295146,-0.023309393,-0.084830336,0.06054687,-0.02402849,0.02449279,0.019630598,0.013989557,0.04544851,-0.054352015,-0.054893196,0.03532771,0.013582008,-0.0136859985,-0.033465974,-0.06452176,-0.0109848315,-0.015784768,0.022226732,-0.04298271,-0.009108623,0.05647537,-0.016751774,0.10740077,0.05884424,-0.025882075,-0.031122547,-0.016040837,0.0298229,0.0025983674,-0.119316645,-0.09879109,-0.02607357,0.03798087,-0.052120093,-0.07617923,-0.057771996,-0.027591996,0.021220047,0.20211375,0.035367116 +1.14.14.64,A cytochrome P-450 (heme-thiolate) protein isolated from the plant Solanum lycopersicum (tomato).,384,1.0,-0.08872754,0.018846376,-0.07239981,-0.0419173,0.11075641,0.09117863,-0.03174787,0.088326566,-0.010341511,-0.022017961,0.06372948,-0.016562872,0.011033647,-0.0074656345,-0.022971869,0.013584316,-0.024463832,0.010943304,0.0004204439,-0.09133556,-0.051706955,0.08993094,-0.016384562,0.030834273,0.011240974,-0.02266113,0.0059498386,0.041029338,-0.058784097,-0.034524154,-0.07383879,-0.0026583462,0.028684638,0.00017254714,0.00482465,0.06991938,-0.042457957,-0.078214526,0.02545898,-0.083946005,0.09897401,-0.00076657016,-0.09002711,0.02845708,-0.008016986,0.028368926,-0.035760198,-0.001236706,0.040860374,-0.040863574,-0.009738346,-0.0055100606,-0.013566096,-0.0049967184,-0.03650072,-0.025375418,0.050429724,0.044195022,0.00064067217,0.022609329,-0.036807302,0.042787727,0.015740026,-0.028500581,0.012947829,-0.05141695,-0.034327503,0.028507087,0.029200112,-0.06261961,-0.016455678,-0.094603114,-0.0066769496,0.03763566,-0.1213173,0.10728783,-0.027609425,0.03856803,-0.026704555,0.0313744,0.05964654,0.003932834,-0.020544874,0.11317048,0.01947829,-0.019472184,-0.06996186,0.0641485,-0.038942378,-0.03532649,0.028476685,0.02792071,-0.037507303,-0.008879313,-0.073969014,0.04381915,0.017543465,-0.028728427,-0.042096175,0.00041552816,0.048962116,0.023011426,0.013815624,-0.10055654,-0.05679205,-0.003623065,0.019840881,-0.020398127,0.032875687,-0.05167063,-0.013418614,0.0016107835,-0.036813885,-0.0853394,0.01272106,0.032739956,-0.0017082964,0.018430222,-0.01369843,-0.036386132,-0.045393225,0.048448768,0.06284364,-0.011519116,-0.012977182,-0.014862171,-0.1306526,4.5931946e-34,0.06672836,0.049239535,-0.007754067,0.0067538326,-0.011587729,-0.02375052,-0.03245247,0.116113976,-0.012674062,0.011503182,-0.112107605,-0.0849162,0.03190089,-0.073272444,-0.044943262,-0.012364993,-0.05986516,0.011128996,0.046963047,-0.0011503744,-0.09349823,-0.045283727,-0.035172887,-0.0012859224,0.007314711,0.03363218,-0.040879652,-0.08897088,0.054601762,-0.023099437,-0.046503168,-0.04705315,-0.049865842,-0.015390856,0.05860303,-0.03937446,-0.02772103,-0.022801857,-0.08008765,0.037252236,-0.015779369,0.0008880913,0.066559784,-0.06294687,0.06421435,0.030432465,-0.13583939,0.034598358,-0.013127945,0.015314053,0.041280635,-0.08509726,0.074087955,0.024944758,-0.049287308,0.01285901,0.030304214,0.050664894,-0.0025023783,0.07667646,0.066294044,0.059221786,-0.057472758,0.033513058,0.033394158,0.0893163,-0.113521524,-0.031099971,0.011213219,0.079540305,0.0038264524,-0.045842625,0.070169054,-0.04908479,0.05579278,-0.0068514035,-0.009172066,0.07229297,0.020823237,0.08021307,0.03328757,-0.042426806,0.026540173,-0.021251572,-0.018473728,0.007609188,0.06012939,0.0040697865,0.019870294,0.04671821,0.102629624,-0.05420256,0.031300448,0.006222761,-0.047695693,-7.2229724e-34,0.06266978,0.015044693,0.01886538,-0.06424479,0.00087212556,0.030554315,-0.021405391,-0.06372851,-0.011641472,0.0022145554,0.11474342,-0.05800684,0.021511136,-0.03403049,-0.018713983,0.06706869,-0.025510784,0.07253089,-0.0024483784,0.091086715,-0.08512276,-0.026170077,0.036808822,-0.028136458,0.047019903,-0.002595914,0.026313104,0.008613547,0.04668634,-0.008655366,-0.041274797,0.03603809,-0.07700393,-0.05645902,-0.003993344,0.02124571,-0.014362821,-0.04878586,0.06576383,0.09110259,-0.06496036,0.118480705,0.007661519,0.05413186,0.044701003,0.060107008,-0.019963678,-0.037059724,-0.077199236,0.015947407,0.07474375,-0.019739723,-0.033498242,0.014653949,-0.056047987,-0.0016994155,0.000649801,0.09116688,-0.04943069,0.007892329,0.06508169,-0.07724895,-0.07520051,0.07554942,-0.01098502,0.078307815,-0.020173483,0.06729775,-0.012608072,0.012045288,0.016794562,-0.012603105,0.10787167,0.09334735,0.0272813,0.008859426,0.027533248,-0.002681259,0.012977071,0.023293398,0.0010619562,-0.006001954,-0.06474609,-0.06651647,0.022595525,-0.07225643,-0.065635644,0.08716765,0.012381853,-0.024763763,-0.03339617,0.07182326,-0.020944893,0.076521255,0.12981358,-2.5592428e-08,0.023305101,-0.10024697,-0.041339286,-0.024564987,0.06236839,0.0064405454,0.0077369264,-0.0010821248,0.052449197,0.022857713,-0.011027467,0.020329114,-0.10183826,-0.028087966,0.03513657,0.0030992776,0.045795836,0.06396899,0.049784712,0.07652881,0.0138802,0.052057054,-0.07968954,-0.032617517,0.038881194,-0.092531905,0.0068082255,-0.043083753,0.07206821,0.014629571,0.03239998,0.03497462,-0.054879904,-0.077976465,0.027176525,0.049809225,-0.034357753,-0.05941267,-0.0051142485,0.02082799,-0.048763294,2.90578e-05,-0.089949615,-0.024984855,-0.008998026,-0.042316034,0.055648867,0.063979186,-0.042361986,-0.042986706,0.001753334,0.0032489463,0.074400775,-0.11438218,-0.035165895,-0.025195431,0.077590585,-0.023867171,-0.052038655,-0.07557673,-0.0563137,0.03644982,0.16000022,0.011609866 +1.14.14.65,A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11-hydroxysugiol. It also oxidizes at C-12 of ferruginol (EC 1.14.14.60 ferruginol monooxygenase).,384,1.0,-0.042081766,0.03116561,-0.054322354,0.024438757,0.10925856,0.11016324,-0.06995879,0.0924594,0.030776884,-0.047087353,-0.0055071744,0.025470832,-0.019451194,0.004005231,-0.058798775,0.008361664,-0.055817995,0.06494963,-0.02184194,-0.030505545,0.07055652,0.030604705,0.023519875,0.028178386,0.011564803,0.0028770927,0.027099224,0.07019437,-0.083741374,-0.090888694,0.012121032,-0.011586189,0.09071371,-0.03678995,0.033958778,0.09225984,-0.0014850947,-0.11427375,0.021056328,-0.009631732,0.028235778,-0.045555484,-0.091196,0.008763833,-0.041142337,-0.07601323,0.0062873056,-5.5158496e-05,0.059842184,-0.047498856,-0.042069126,-0.080344886,-0.029631387,0.04337162,-0.011705916,-0.029299133,0.025093513,-0.033743456,0.0052902536,-0.017905882,-0.06963995,0.043354254,-0.0006416575,0.0029662845,-0.017952947,-0.05193543,-0.0201222,-0.025942098,0.002985585,-0.081526965,-0.021289645,-0.06998433,-0.02166915,0.033791278,-0.06930923,0.032347847,-0.03081496,0.0008157683,0.02789398,0.003545634,0.015680345,0.023820063,-0.014528944,0.098175615,0.113346174,-0.020262554,-0.0135676,0.0088305315,-0.029571233,-0.010589571,-0.0032691814,0.04737258,-0.0016119856,0.012268153,-0.0764092,0.025393408,0.009194648,-0.024158727,-0.043206573,-0.014512771,0.03818065,0.077022456,-0.021119192,-0.13130602,-0.03994799,0.04038555,-0.02397044,0.041136127,0.022624955,-0.080361895,-0.052621998,-0.03278342,-0.008529857,-0.031446062,0.0012933915,0.07030771,-0.016706346,-0.032280285,-0.054948848,-0.043462113,-0.03153693,-0.052115604,0.0129511915,0.011740561,-0.026107863,0.04197279,-0.10578844,5.3360776e-33,0.09176767,-0.0016835965,-0.034341488,0.035429657,-0.04212473,0.00082735287,-0.033677235,0.098940544,0.006727269,-0.028127557,-0.08749271,-0.04786145,-0.006642478,-0.061086927,-0.0035347969,-0.03499187,-0.016595943,-0.0012616802,0.07370559,0.02762488,-0.026543599,-0.010467667,-0.041863944,-0.05739843,-0.010370859,0.07281476,-0.024660936,-0.033520166,0.058858577,0.03308867,0.017713659,-0.051088538,-0.068085864,-0.019095752,0.018783074,-0.060444146,-0.015646456,-0.0018696669,-0.05738902,0.08442805,-0.043802418,0.025018,0.025118021,-0.08461192,0.0992402,-0.012222404,-0.106252745,0.06495581,0.064213,0.06303089,0.05674304,-0.046368238,0.09171507,0.05168682,-0.044535637,0.012466103,-0.0066678436,0.024595454,0.0074726534,0.07044299,0.084405,0.075982295,-0.0018667792,0.0046035354,0.07537993,0.06239631,-0.055703346,0.03145096,-0.030402156,0.14839232,-0.042493746,0.026760202,0.037101585,0.010518224,0.01882272,-0.04463014,-0.034396227,0.076446995,0.08457914,0.028689226,0.054015487,-0.041522797,-0.005782144,0.021552501,-0.0114120925,0.008811659,0.04181689,0.017701449,-0.04409599,0.05521406,0.1285648,-0.09694762,-0.00035738724,-0.0061438433,-0.026403839,-4.6291445e-33,0.10545046,-0.042157277,0.013188218,-0.09710426,-0.07487232,0.08144515,-0.005894302,0.014076057,-0.035084803,0.045381438,0.06953037,-0.074700505,0.045915637,-0.07275035,0.0077368366,0.026802514,-0.01796856,0.043067794,-0.071578205,0.04137472,-0.07242817,0.01086086,0.053993516,-0.006742108,0.062941425,0.010980688,-0.0015368602,0.014557951,0.049617898,0.027793162,-0.0044650068,0.049784295,-0.084321335,-0.10227307,-0.077654116,0.025295498,-0.05358784,-0.033371206,0.07653086,0.055564187,-0.014254973,0.07046829,0.009519809,0.057390407,0.05457799,0.062355164,-0.100944966,-0.064799815,0.0066442396,0.010934978,0.02048595,-0.010092884,0.0016598833,0.014150553,-0.017578488,-0.026759474,-0.04518064,0.025074665,-0.049720146,-0.040884133,-0.012332747,0.00160577,-0.071248084,0.07378955,0.0053708055,0.06906128,-0.028196936,0.05316485,0.021927653,0.049799554,0.039808508,-0.011010294,0.091816604,0.06689724,0.008780496,0.027692186,0.0030571949,-0.00867978,-0.007918115,0.035878725,0.043150768,-0.0033331315,-0.052015,-0.101184234,-0.035982158,-0.08873242,-0.03835584,0.082193606,0.053971253,-0.021580528,0.0026789932,0.061010547,-0.03860707,0.048646554,0.09954593,-4.0081876e-08,-0.040235408,-0.09098866,0.03558521,-0.0036650894,0.044097643,-0.0031685766,-0.008313715,-0.01764839,0.029283209,-0.0031766496,0.005705226,0.09766161,-0.022030167,-0.047427922,0.005049257,0.007849539,0.072756484,0.048818227,0.065793954,0.069540724,-0.059600133,0.022865612,-0.028867844,0.070024304,0.013377378,-0.11691389,0.051921595,-0.0536683,0.082862236,-0.007149445,0.022951135,0.028678002,-0.025798215,-0.04486273,-0.039325267,0.058149464,-0.05646018,-0.03754175,-0.028516915,-0.011150965,0.027285377,-0.07316915,-0.07877902,-0.028188631,0.042672507,-0.013565484,0.018074447,0.009676964,-0.042605132,-0.0670589,-0.009878506,-0.008662302,3.7957318e-05,-0.09005706,-0.11797177,0.032079548,0.056986474,-0.04025849,-0.037821963,-0.114000805,-0.023845892,0.00085332914,0.15457882,0.014240901 +1.14.14.66,"A P-450 monoxygenase involved in psoralen biosynthesis, see EC 1.14.14.141, psoralen synthase.",384,1.0,-0.036437288,-0.013260907,-0.103836864,-0.00020442854,0.07153243,0.07820013,-0.085452445,0.040245544,-0.024353769,0.013501228,0.011520555,0.007830148,-0.013197087,-0.023560788,-0.016008237,0.012996553,-0.04677707,-0.005499897,-0.004915933,-0.06597501,0.009571634,-0.010799429,0.0194153,0.011725446,0.009874411,0.035488885,0.044556778,0.015389522,-0.067212164,-0.0014764584,-0.066963755,-0.012969736,0.017088713,0.023488408,-0.0005503888,0.08864492,-0.03436642,0.027494377,0.0444807,-0.0053938366,0.02872134,-0.05802984,-0.07940391,0.028642202,-0.06648446,-0.022489319,-0.072261006,-0.006439567,0.04094711,-0.06796563,-0.044324785,-0.013521296,0.050494105,-0.012154113,-0.060763046,-8.4442676e-05,0.07118439,-0.02658498,-0.013514924,-0.0071031116,-0.056583807,-0.058053516,-0.073520534,-0.004947072,-0.028713256,-0.03422879,0.071057044,-0.065258905,-0.015852833,-0.021503132,-0.08203942,-0.004644605,-0.027834859,-0.006045699,-0.08075108,0.11025625,-0.03993453,-0.09760161,-0.023991082,0.072569564,0.04088044,0.05554775,-0.02380115,0.059685837,0.0853853,0.020942125,0.031361848,0.0772778,-0.034771286,0.046362422,-0.022956716,-0.040653303,0.017316198,0.06560575,-0.08583555,0.08411519,-0.002963622,-0.016175672,0.025361838,-0.071655914,-0.011064016,0.016815526,0.03248215,-0.03337745,-0.044581193,0.0024506764,-0.038418584,0.06275456,0.030188067,-0.032338828,-0.0026592698,-0.0838621,-0.021924691,-0.013133391,0.0060578384,0.10300362,0.020946233,-0.014602619,-0.02959179,-0.009682943,0.00036754675,0.06579424,-0.042773224,0.092901394,-0.038373735,0.045653407,-0.054246098,3.0025834e-35,0.07910154,0.07761262,0.0139906155,0.0049084877,0.008114635,0.06466197,-0.059804868,0.05042548,-0.018938748,-0.057581957,-0.056649745,-0.09662036,0.033568524,-0.016934544,-0.07326891,-0.009881059,0.02958226,0.044668388,0.065059446,-3.4553672e-05,-0.0643995,0.023774154,-0.038925976,0.01502929,0.0067178234,0.070352904,-0.039012644,-0.009343168,0.048794888,0.0039162086,0.020876488,-0.055604797,-0.0501812,0.024593111,0.015302793,0.012923191,0.017340226,-0.055830665,-0.050167408,0.04996422,-0.035151392,0.056702115,0.019738397,-0.04443821,0.036590986,-0.07912481,-0.058740467,0.08183136,0.013417545,0.13833074,-0.010489279,0.02929174,0.11079847,0.03492798,-0.06410362,-0.0005840315,-0.014827009,0.008598859,0.032393727,0.05340886,0.097911075,0.06760738,-0.0023621346,0.028299212,0.05237023,0.057835244,-0.03025405,-0.009538916,0.0014602538,0.119265966,-0.07355983,0.017947545,-0.023306282,0.049293377,0.09543328,-0.031947996,-0.025365464,0.080961525,-0.002652296,0.03701789,-0.04211134,-0.01204134,-0.03275539,0.023797827,-0.0070036654,0.015539597,-0.043435182,-0.024399823,-0.034927763,-0.018447433,0.055272277,-0.10850718,-0.014357703,0.11573774,-0.033443063,-1.0473529e-33,0.049586553,-0.11745357,-0.01562087,-0.0701483,-0.09500655,0.12418635,-0.0171708,-0.01579915,-0.09373985,0.012535598,0.08928996,-0.036405016,0.01970974,-0.0540644,-0.018669477,-0.037652858,-0.0019981663,0.07469677,0.037021577,0.052690513,0.03243843,0.09058864,-0.007527437,0.049873292,0.067392804,-0.03388154,0.08068181,0.039978694,0.0047492282,0.017325154,-0.036318824,0.039445177,-0.05713608,-0.040264525,-0.013991316,0.025068317,-0.052156873,0.044676967,0.06616331,0.07465669,-0.027998736,0.075086266,0.03512635,0.03531673,0.023143195,0.059424605,-0.031193217,-0.013756252,0.0894673,-0.07144445,-0.04693478,0.03615549,-0.023884455,-0.021069335,0.014378106,-0.067823015,-0.063896164,0.013030363,0.026363803,-0.15303215,-0.045699984,0.029875984,-0.010592774,0.08405408,-0.0049566533,0.08591982,-0.010278152,-0.04822404,0.041809548,-0.0062314635,-0.0026013143,-0.033539187,0.065546356,0.06678039,-0.048983533,-0.017977636,-0.038313884,-0.016585564,0.05539458,0.08330814,0.05947363,-0.00825303,-0.017531611,-0.04737737,-0.022678219,-0.08632467,0.012082429,0.06582416,0.016114717,0.009821033,-0.014582551,0.06455032,-0.05215716,0.049612526,0.04887046,-2.4700634e-08,0.1107147,-0.0413882,0.046929266,-0.020639166,0.019201782,0.0050654337,0.05938107,-0.004725773,-0.007291252,0.0011325474,-0.026740529,0.020267392,0.04420776,0.027178135,0.024555549,-0.014575169,0.05419838,0.05806875,0.024703458,0.014351211,-0.12263913,-0.069726616,-0.00063968217,0.032536235,0.03653862,-0.067377515,0.037705563,-0.050069563,0.08649748,-0.07921733,-0.05798604,0.007237718,-0.105028346,-0.06732989,-0.042242218,0.05661475,-0.06616016,-0.030391447,-0.002177322,0.0012395987,-0.004075787,-0.082942136,-0.024245003,0.0038669356,0.051748637,0.0033002228,0.037059728,-0.05054927,-0.030468227,-0.016238352,0.04591447,0.0053647216,-0.010109278,-0.0024552157,-0.11480583,0.07786118,0.034736447,-0.10724858,-0.08865271,-0.061030205,-0.026784323,0.059823807,0.14659148,-0.017793402 +1.14.14.67,"A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11,20-dihydroxyferruginol.",384,1.0,-0.051624283,0.031126179,-0.028622976,0.0017970282,0.0976499,0.116362594,-0.05621757,0.11641676,0.028348735,-0.021398297,0.020453842,0.023908546,-0.03530426,0.004037219,-0.04433517,0.025349284,-0.043230966,0.06383122,-0.029743435,-0.034635067,0.07395557,0.039157152,-0.002733783,0.019855835,0.02785296,-0.0030948857,0.026275422,0.06766056,-0.06995621,-0.059806965,0.0066976165,-0.026269145,0.080714725,-0.039392937,0.06165468,0.078116834,-0.00707491,-0.13164303,0.0021023024,-0.011212193,0.063003704,-0.035760112,-0.09828141,0.00677566,-0.019797193,-0.05673567,0.0064827274,0.0100497985,0.08567051,-0.05192614,-0.038233675,-0.0919725,-0.019347398,0.030937698,-0.044822592,-0.02068563,0.03168768,-0.0072088134,0.0104361465,-0.016377944,-0.060381,0.03641253,-0.008544725,-0.03929012,-0.0004434734,-0.044803843,-0.03140453,-0.010903849,0.031321924,-0.087991595,-0.006373194,-0.060868014,-0.02358703,0.05342606,-0.06379209,0.027781393,-0.037616808,0.023894973,0.022006297,-0.0022710578,0.017246272,0.022037964,-0.017099326,0.08327107,0.08164814,-0.005796938,0.012474587,0.045968376,-0.0054990575,-0.04154087,-0.035202917,0.029745119,-0.02156717,0.003070334,-0.08504532,0.049724564,-0.017824078,-0.019633971,-0.05077162,-0.0036220371,0.06560086,0.06609225,-0.011238801,-0.14413482,-0.040196933,0.042339187,-0.012869958,0.016880764,0.018220296,-0.09361424,-0.05512938,-0.035378408,-0.018809067,-0.040355828,-0.0034611395,0.04766337,-0.029943908,-0.026646141,-0.04949992,-0.063223146,-0.028994573,-0.043200407,0.021968935,-0.0036729611,-0.0049199783,0.05935636,-0.11067771,4.03543e-33,0.083314046,0.001117162,-0.023438064,0.042915132,-0.057287503,-0.012060161,-0.03968226,0.12546702,-0.013902693,-0.057125065,-0.086356096,-0.07377378,-0.0029559177,-0.07706535,0.010396182,-0.025142284,0.006792185,0.0034921626,0.09146914,0.021308694,-0.05025196,-0.01779124,-0.037702747,-0.049928915,-0.0035716502,0.05413714,-0.013811631,-0.050880503,0.07973083,0.02220769,0.0029735526,-0.06641271,-0.046768326,-0.026649212,0.034540888,-0.04872734,-0.004592991,-0.003959404,-0.04562182,0.06367719,-0.04274838,0.015327491,0.031967938,-0.06919843,0.08871558,0.007317466,-0.12172828,0.013189164,0.0429296,0.010682684,0.052019227,-0.043835275,0.0990683,0.079323515,-0.045865938,-0.010611313,0.00090147654,0.035253014,-0.0023894033,0.05614258,0.0868132,0.082645096,-0.013679639,0.028139068,0.07217639,0.07192807,-0.061861623,0.038353804,-0.026303485,0.1365351,-0.043588832,0.0014103884,0.024127273,0.013274373,0.0030151596,-0.052808452,-0.0012231856,0.08665957,0.06922928,0.027490057,0.035011474,-0.02673993,-0.016854769,0.044612974,-0.03754187,-0.0069981497,0.055344384,0.030652186,-0.034320474,0.042368107,0.11989924,-0.09220458,0.017483179,0.027484598,-0.04312802,-3.2075817e-33,0.085082814,-0.033743743,0.013605917,-0.08799283,-0.067838565,0.093916275,-0.013027056,0.011665987,-0.049296364,0.039161857,0.078865595,-0.09461715,0.030240575,-0.055253085,-0.008119175,0.033191856,-0.02032534,0.033866823,-0.06915363,0.057026904,-0.062047675,0.013171765,0.06993911,-0.005638174,0.030910172,0.01752475,0.028099313,0.021465192,0.03795624,0.0342115,0.00847399,0.044885967,-0.08508487,-0.118906245,-0.08901331,0.033463895,-0.023696499,-0.056936618,0.08372675,0.054362018,-0.018384596,0.07463841,0.00097727,0.051633853,0.05320623,0.07846625,-0.061367076,-0.058870003,-0.035478923,0.0003309664,0.04616308,-0.024692273,-0.0024635894,0.00856918,-0.031667672,-0.035677362,-0.04734982,0.031584732,-0.05049048,-0.04768403,-0.009272305,-0.0066575264,-0.07400371,0.08292562,0.00021148291,0.0880794,-0.0035443436,0.054792356,-0.00063925143,0.030337336,0.02479904,0.007138817,0.09054559,0.10933591,0.019189492,0.042012706,0.0129660005,-0.010391375,0.0034727252,0.025363192,0.010124745,-0.020630945,-0.058480762,-0.10369621,-0.011607966,-0.073943414,-0.0310613,0.08047657,0.04402712,-0.013754085,-0.0013984714,0.055693164,-0.033387445,0.07302915,0.0959402,-3.4539397e-08,-0.0070238286,-0.09350076,0.021339718,-0.026029449,0.015837062,-0.03274197,0.005439828,0.0162488,0.037453033,0.020081736,-0.014195852,0.06901564,-0.05070559,-0.03847204,-0.00544019,0.017079063,0.07817273,0.05325741,0.05711224,0.058546145,-0.024324073,0.031877413,-0.025483184,0.05960271,0.011900925,-0.12162862,0.05078093,-0.04576355,0.06996973,-0.01275292,0.042099882,0.025068633,-0.025303056,-0.036994863,-0.012161602,0.07063275,-0.03856316,-0.03658799,0.00045222268,-0.013274213,0.026533071,-0.06562957,-0.08428981,-0.024469683,0.045648642,-0.025348144,0.04389049,0.012391009,-0.03430455,-0.07647414,-0.014682803,-0.003506852,0.013723047,-0.107663125,-0.12546507,0.008958134,0.055710535,-0.041097574,-0.037165247,-0.107874304,-0.013418272,-0.013674115,0.12275681,0.036039624 +1.14.14.68,"A cytochrome P-450 (heme-thiolate) protein isolated from rice, Oryza sativa.",384,1.0,-0.08605406,-0.012771263,-0.02877528,0.008374576,0.044331223,0.107380085,-0.02849604,0.052976847,-0.019069191,-0.013778032,0.11305038,0.027986286,0.0005127398,-0.004490175,-0.01916818,0.009051547,0.02243878,0.0056920163,-0.052992504,-0.1108667,-0.0075819027,0.053144906,0.0030088297,0.021999914,0.03760312,-0.027047155,0.028345134,0.05388222,-0.02350694,-0.061267473,-0.0673691,-0.031597752,0.02380232,-0.0073839445,0.060241215,0.036012948,-0.0034680013,-0.11175666,0.028152978,-0.09962487,0.0921503,-0.02977265,-0.046384607,-0.00095119525,-0.018483197,-0.040828962,-0.03349688,-0.018045599,0.0685914,-0.051689595,-0.0084598465,-0.0039034546,-0.015251321,0.041353825,-0.056199923,-0.043891504,0.04443416,0.036994383,-0.07924429,0.046231754,-0.07047767,0.059991173,-0.02349479,0.009664042,-0.02802925,0.015257796,-0.07722096,0.021721156,0.03018546,-0.038064856,0.010628322,-0.07872196,0.06660829,0.068568125,-0.07154766,0.029301215,0.03774026,0.014536768,0.018725438,-0.029347926,-0.007515219,0.01739883,0.04063496,0.11425706,-0.022663511,0.010370367,-0.085408,0.11474266,-0.003886706,-0.08143164,0.022859354,0.059405226,-0.01199462,-0.00013385457,-0.026252305,0.0664196,-0.0053671277,-0.037037738,-0.0060698,-0.02232282,0.08103407,0.07075268,-0.01128408,-0.120832026,-0.02236402,0.035176754,0.00372899,-0.002106498,0.02702677,-0.05956952,-0.003959396,0.0007065745,0.0043421825,-0.003337231,-0.07271498,0.0115103945,0.0015210055,-0.02975274,-0.051504068,-0.09122312,-0.034079973,-0.0078068865,0.001884884,0.019705959,-0.034943692,-0.004179367,-0.075484075,3.8092728e-34,0.06629676,0.029821921,0.043394137,-0.017881049,-0.007547689,-0.015846508,-0.0035047105,0.03655473,0.005768284,0.003180006,-0.118694104,-0.09410147,-0.020059546,-0.045374345,0.015219755,-0.0013273199,-0.060656082,0.02185742,0.05102086,0.011771188,-0.07761559,0.03450624,-0.05247601,-0.03461965,0.027698947,0.049254116,0.0014919137,-0.08956816,0.0045093964,-0.01616743,-0.038214296,-0.044512242,-0.074750856,-0.05263435,0.004199104,-0.038754426,0.01978982,0.023511492,-0.08110457,0.06896739,0.0323242,0.039490078,0.0343878,-0.0346254,0.04567251,0.018283049,-0.10048118,0.059056103,-0.03662894,0.012794792,0.0063982494,-0.07082904,0.054455373,0.07544021,-0.0353471,-0.015159738,0.04320549,0.039927207,-0.001051452,0.046834584,0.042151257,0.03319952,-0.04483933,0.062483393,0.021423543,0.0236721,-0.11587312,-0.05425518,-0.027322482,0.115949504,-0.023483142,-0.05981481,0.011178509,-0.06783943,0.013517976,-0.05229206,-0.028274037,0.03341422,0.052847393,0.077197395,0.07969896,-0.039404243,-0.017272104,-0.0041528726,-0.07641668,0.050983146,0.024926892,0.037934296,0.030418105,0.03575517,0.10134026,-0.037952144,0.045107745,0.007328829,-0.06916906,-5.3543653e-34,0.053934556,-0.04317752,0.039834287,-0.04247836,-0.016785512,-0.023743829,0.005033459,0.03292661,0.038247768,0.014070158,0.11750428,-0.058027703,0.03687632,-0.046445068,-0.02055211,0.10898063,-0.028966004,0.09747173,-0.010881926,0.10681532,-0.06794571,0.01741734,0.042805932,-0.002716216,0.03273609,0.05366003,0.050525516,0.037180014,0.00031761287,0.019614015,0.025702506,-0.021819,-0.09839471,-0.0886314,0.0098235905,0.005596284,0.015442964,-0.070638716,0.043207716,0.061024766,-0.05803001,0.12336713,0.035481915,0.023046877,-0.0132569205,0.06766304,-0.079084896,-0.041049182,-0.07785235,-0.018730555,0.029264456,-0.06614832,-0.0007203825,0.01842694,-0.07665058,-0.01603024,-0.014534037,0.059506353,-0.08516726,-0.045771524,0.01957195,-0.0010243888,-0.032774907,0.052209828,-0.009736758,0.09752635,-0.0009854676,0.01678946,-0.013080354,0.008223171,-0.035299204,-0.011127171,0.07673829,0.11513568,0.014724947,0.050298236,-3.0853156e-05,-0.005188736,0.06538485,0.035515185,0.010063975,0.008309637,-0.07494854,-0.057463396,0.024631927,0.017472142,-0.08100704,0.1503359,0.102975644,0.00634877,-0.0056898836,0.01954476,-0.021945374,0.086855315,0.08509911,-2.5169538e-08,0.018171737,-0.15419419,-0.027759433,0.008007032,-0.054691188,-0.018435907,0.03370406,-0.014961148,0.101711474,-0.0036235908,-0.014194151,0.04911375,-0.09222415,-0.0048376694,-0.059613347,-0.011951154,0.08292257,0.062962435,0.0505393,-0.002876696,-0.008426877,-0.0044023213,-0.02140958,-0.013743802,0.051210534,-0.023211058,-0.027218308,-0.031338703,0.10907121,-0.02294693,-0.012162881,0.009684457,-0.051521197,-0.037560735,0.09930554,0.07676622,-0.018649567,-0.059377715,-0.0052863997,-0.006609262,-0.008150599,-0.033599768,-0.036494985,-0.041402686,0.028614786,-0.0763174,0.066042155,0.06402468,0.0020791984,-0.03139666,-0.03562676,-0.027607914,0.03701751,-0.13451208,-0.06893053,-0.02464439,0.061871845,-0.015851293,-0.043815825,-0.060574647,-0.0003769653,0.0015082497,0.112163946,0.00036996356 +1.14.14.69,"A cytochrome P-450 (heme-thiolate) protein isolated from the plant Oryza sativa (rice) that is involved in phytocassanes biosynthesis. Depending on the order of activities, the enzyme may form either ent-cassa-12,15-dien-2-one or ent-cassa-12,15-diene-2beta,3beta-diol as an intermediate.",384,1.0,-0.106992684,0.016366074,-0.0890256,0.02087802,0.047480654,0.12169637,-0.026804823,0.054812856,0.01776398,-0.0032977073,0.0857767,0.0075471103,-0.05905627,0.008246492,-0.054563217,0.03701029,-0.06256342,0.036952823,-0.043109417,-0.13062838,0.0059498684,0.06439203,0.030584488,0.032654293,0.030706435,-0.037026618,0.022944067,0.06075845,0.023556134,-0.062162433,-0.07021695,-0.018752279,0.024284054,0.00059867575,0.033635143,0.0961581,-0.009709439,-0.118492596,0.03235005,-0.07734878,0.078078166,-0.019026976,-0.07479481,0.015188817,-0.02461549,-0.047178186,-0.025635751,-0.03862802,0.040543992,-0.065639965,-0.019682007,-0.0030491697,-0.061545458,0.0330161,-0.04106757,-0.0069733947,0.051710892,0.012634888,-0.03580544,0.029995894,-0.0045560044,0.037140496,-0.044439517,0.014669985,-0.04887151,0.010169044,-0.057549037,-0.0031662558,0.028741479,-0.05820458,-0.014154909,-0.100306295,-0.039205246,0.07836564,-0.07576357,0.042498153,-0.0013170495,0.045079812,-0.039325617,-0.028787468,0.030518966,0.009480428,0.022762366,0.10682517,0.010718943,0.002754449,-0.073295586,0.12522916,0.039640725,-0.06069406,0.0016053767,0.02894378,-0.03691157,0.01318232,-0.061202813,0.082420245,0.014423578,-0.07673088,-0.008914272,0.017607583,0.063511334,0.034385532,-0.02666079,-0.08709555,-0.028754845,0.0401678,-0.022166315,-0.018658193,0.028188871,-0.028039737,-0.044848546,-0.030831082,0.030148877,0.014131871,-0.064979166,0.06523297,-0.021090508,-0.04969729,0.022532111,-0.07783343,0.0022014903,-0.023068788,0.023466518,0.03949535,-0.044360444,0.014535292,-0.11548139,2.0049704e-33,0.12809563,0.024784124,0.03837098,0.019252092,0.02206423,-0.00043233382,0.0064391065,0.03213352,-0.01175481,-0.031247372,-0.14209235,-0.09139286,-0.00025151655,-0.048761424,0.015695984,0.0038087855,-0.062905505,0.032858815,0.05974479,0.03688726,-0.084100336,0.033838622,-0.07914478,-0.0064829723,0.04637096,0.07037702,-0.009884947,-0.06007374,0.03424946,-0.008553945,-0.013276977,-0.058292717,-0.049715415,-0.06420375,0.017096926,-0.05733113,-0.004867832,0.0013206964,-0.064133726,0.062341437,0.024132958,0.03495162,0.036998875,-0.04643576,0.065307945,0.011897277,-0.07294299,0.079009876,0.002872276,0.03140936,0.013589607,-0.019827336,0.09792871,0.06666174,-0.044626806,-0.019855212,0.029333146,0.04842922,0.017532477,0.06248747,0.04067925,0.024802044,-0.009620767,0.057977773,0.030479796,0.05293528,-0.14432347,-0.05171394,-0.04940814,0.118067265,-0.06563772,-0.046823,-0.00730243,-0.05023143,0.039771434,-0.053765427,-0.028470095,0.028767293,-0.011394399,0.05100949,0.046241336,-0.031649534,-0.0013762627,-0.011146537,-0.053800307,0.021473212,-0.020320361,0.0037726106,0.0045718197,0.0044951835,0.045111533,0.0026052657,-0.0028199914,0.029414708,-0.011619676,-1.5599728e-33,0.050261457,-0.024933545,0.025398446,-0.058015905,-0.015317493,-0.0027557658,-0.003567626,0.007020071,0.043556713,0.051485382,0.08153619,-0.044562977,0.083958276,-0.059062142,-0.024211805,0.0529496,0.008149527,0.10855694,-0.021989405,0.09091229,-0.05106708,0.08114706,0.0060507883,-0.024081906,0.041311987,0.047436588,0.014159766,0.05308129,-0.016975759,0.019432127,0.00805306,-0.038363572,-0.073543005,-0.043712795,-0.038079955,0.007357901,0.0068840063,-0.050201494,0.02487102,0.09804357,-0.033403184,0.11735943,0.052980624,0.07024894,0.022502977,0.05477058,-0.067159995,0.023645736,-0.069980666,-0.026019778,0.017033795,-0.030654252,-0.005529612,0.05614575,-0.0020075224,-0.012208155,0.021868432,0.045770403,-0.06506519,-0.040351212,0.027292714,-0.02756337,-0.016377043,0.029146915,0.014782817,0.10962921,-0.025534676,0.077910684,-0.0055468054,0.027709499,0.0059914705,-0.04210022,0.031156978,0.11088403,-0.030358683,0.05445884,-0.034073252,-0.05455349,0.013057174,0.029109498,-0.032474343,-0.02309079,-0.031884737,-0.10193287,0.003716468,-0.050490994,-0.048632406,0.13513662,0.075192615,0.016009204,-0.010878463,0.020903189,-0.029104777,0.116578676,0.07768718,-4.4013696e-08,0.015974058,-0.13049075,-0.04357771,0.008183771,-0.05056802,-0.054706477,0.05354036,0.004964851,0.098925404,-0.00826133,-0.03767458,0.03891225,-0.04976644,0.011073569,0.011579815,0.031837635,0.079521924,0.09048635,0.021273881,0.006584388,-0.0052224426,-0.017173218,-0.027377274,0.014765088,0.019330598,-0.07028609,-0.017127968,-0.013027642,0.08602045,-0.0076911133,0.0045850575,0.009821869,-0.008174245,-0.017155051,0.0059581404,0.10863881,-0.048843015,-0.041030917,0.00074086554,-0.005566591,-0.0133318035,-0.06377556,-0.05247699,-0.010688176,0.008792258,-0.03738423,0.063247785,0.014701515,0.010569594,-0.050027687,-0.024535205,-0.03687933,0.05832376,-0.13638991,-0.07118698,-0.0011437191,0.034533508,-0.006789287,-0.035644725,-0.09476946,-0.024168022,0.030076941,0.17472385,0.013019217 +1.14.15.25,"The enzyme, characterized from several Pseudomonas strains, initiates p-cymene catabolism through hydroxylation of the methyl group. The enzyme has a distinct preference for substrates containing at least an alkyl or heteroatom substituent at the para-position of toluene. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. In Pseudomonas chlororaphis the presence of a third component of unknown function greatly increases the activity. cf. EC 1.14.15.26, toluene methyl-monooxygenase.",384,1.0,-0.060921792,-0.045381412,-0.06688747,0.020210588,0.0628063,0.0843241,-0.05110566,0.03364211,-0.00044326278,-0.024216462,-0.01002147,-0.04337809,-0.0041586813,0.0873664,-0.08024258,0.0075514833,-0.046592742,-0.03303719,0.06681184,0.014249591,0.062805966,0.018994361,-0.045929067,-0.037099093,0.0097586885,0.060697213,0.05436483,-0.046221506,-0.077454194,-0.009648764,-0.06328311,0.035178203,0.06479737,-0.0590218,-0.0025399528,0.1367224,-0.024944201,-0.014792595,0.07443523,0.0045814496,0.038125034,0.005945991,-0.03704596,-0.089933164,-0.038760994,-0.01553018,0.08385217,-0.00237418,0.059150785,-0.061761595,0.011287868,-0.0052276268,0.07046966,0.042058945,0.0010408047,0.009628605,0.07063193,-0.036737587,-0.057971466,-0.07537949,-0.022163652,-0.07703089,-0.026920425,0.06744297,0.030328676,-0.07572185,0.03378345,-0.0108644385,-0.019099113,-0.0754072,-0.07109743,0.017984042,-0.00275928,0.019024543,0.010986323,-0.022561518,0.061998963,-0.037026346,0.0120933475,-0.06499505,0.030478794,-0.024930166,0.021468578,0.08163722,0.09225988,-0.036298327,-0.029976929,0.009063798,-0.021953193,0.038177222,0.013779143,0.018314919,-0.016351907,0.0058298493,-0.06831902,0.03544951,0.03609464,0.017796166,0.019752078,-0.049949262,0.03190192,0.044961788,-0.036930837,-0.07996898,-0.019597221,-0.011402681,-0.034241077,0.08941492,0.074975275,0.003686719,0.017214647,-0.013464285,0.048581205,-0.05693523,-0.02225237,0.06189457,0.072457425,-0.044206213,-0.08948864,0.0043577356,-0.0007364796,-0.038848944,0.02340698,0.0960818,0.0033606465,-0.010459589,-0.113814116,1.9235149e-33,0.08445647,0.022598183,-0.028696502,0.017076025,0.01458641,0.04099801,-0.050054178,-0.004824691,0.012803629,-0.08721811,-0.035179306,-0.052233342,0.011137151,-0.05663544,-0.044304132,-0.025215512,-0.027138133,-0.041240834,0.04770645,-0.032887354,-0.04623506,-0.0016256724,-0.055947497,0.01817631,0.08540213,0.0302488,0.0027923235,-0.011441202,-0.019222235,-0.009668447,0.028392185,-0.047650676,-0.097933285,0.013621143,0.0056600445,0.012263561,-0.020313993,0.0031730568,-0.032968577,0.013976233,-0.0025662405,0.03955103,-0.01104856,-0.0746772,0.093300685,-0.04609472,-0.060377084,0.12612978,0.049641524,0.16591729,0.01877167,-0.061290495,0.11716366,-0.047322225,-0.10173678,0.041129827,-0.027621333,-0.013326593,0.061392877,0.088927515,0.109481215,0.038492832,-0.046463586,0.08378553,-0.049196303,-0.0122550735,0.010775793,-0.0071151596,0.003582811,0.10412663,-0.099933445,0.046493564,0.047689147,0.042528868,0.049181066,-0.031625126,-0.064074196,-0.02023798,0.066476986,-0.011469372,0.05889879,-0.0547121,0.0151948705,-0.018864246,-0.10509083,0.026038611,0.04259565,-0.05440646,-0.008956131,0.001187209,0.1099725,-0.113543354,-0.047024902,-0.008146093,0.021113742,-3.571977e-33,0.06804212,-0.06486242,0.022166628,-0.112197906,-0.02581711,0.0738696,0.029721435,0.029764077,-0.029664414,-0.025573049,0.09742746,0.05306343,-0.037995804,-0.030764975,0.05218932,0.03548061,-0.00029242982,0.040897533,0.016157398,-0.016253093,0.01674744,0.04733392,-0.0032814213,0.054708593,0.028499205,-0.0018693164,-0.07793215,0.064392686,0.09885676,0.06330988,-0.018399818,0.05184069,-0.068838365,-0.014740529,0.032804545,0.03063911,-0.09339924,0.052528083,0.04834413,0.06181785,0.007275402,0.01626478,-0.03795617,0.023263877,-0.015080329,0.079189,-0.09976713,-0.04703886,0.025568148,-0.085037105,-0.040073693,0.038268626,-0.0020590043,-0.005589918,0.023810893,0.010284326,-0.029068008,0.0060284524,0.008342926,-0.030967707,-0.05715798,-0.0664882,-0.029875845,0.015865073,-0.053636055,0.02412008,-0.032021362,0.046879698,0.014603086,0.04333397,0.02541041,-0.011716318,0.06644666,0.011435233,-0.13266122,-0.03724537,-0.0028667573,-0.028315213,-0.01855086,0.028040698,0.05956892,0.023585679,0.00191284,-0.049377,-0.019515593,-0.11236479,0.037154496,0.07494071,-0.08338319,-0.044807687,-0.0071618385,0.013623869,0.005151904,-0.004966759,0.017766735,-4.7503185e-08,-0.0054481123,-0.08364265,0.08517855,-0.026530692,0.011048095,0.051838364,0.016739361,-0.030320587,0.020155506,-0.08711088,-0.031614598,0.05189535,0.056310125,-0.008934746,0.06417457,0.06443987,-0.08531988,-0.03064581,-0.01741923,-0.007176309,-0.08426772,-0.023318999,-0.19629052,0.013789682,0.013177705,0.008710098,0.03508548,0.02893082,0.032794554,-0.051305056,-0.025329866,0.000780373,-0.009952089,0.0371367,-0.10129924,0.013382412,-0.07202668,-0.020084232,-0.031802103,-0.003785236,0.03532673,-0.055756748,-0.026821172,0.049218588,0.04556267,0.034351952,0.009271969,0.00030858617,0.035738166,-0.049643014,0.07994024,0.005915889,0.021370457,-0.030800255,-0.06656479,0.075389184,-0.018895302,-0.03800823,-0.042708054,-0.049143735,0.0034750418,0.025253993,0.092467174,2.06657e-05 +1.14.15.26,"The enzyme, characterized from several Pseudomonas strains, catalyses the first step in the degradation of toluenes and xylenes. It has a broad substrate specificity and is also active with substituted compounds, such as chlorotoluenes. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. The enzyme can also act on its products, producing gem-diols that spontaneously dehydrate to form aldehydes.",384,1.0,-0.069805235,-0.03531346,-0.07959235,0.075658016,0.0972155,0.03560142,-0.040496938,0.026204394,-0.02818408,-0.0266599,-0.045881316,-0.0053993347,-0.041628897,0.030713897,-0.100619435,0.03079945,-0.054698233,-0.007524369,-0.013726914,0.01725702,0.06705432,-0.0020899682,-0.041442428,-0.03293996,0.07652614,0.0249763,0.0649105,-0.04447335,-0.036124755,-0.07563255,-0.006024292,0.012417294,0.036748745,-0.04097024,-0.0067136507,0.13575597,0.024488185,-0.035422724,0.015868282,-0.010862241,0.0038896124,-0.000103644816,-0.07559703,-0.06960547,-0.011642838,-0.04681672,0.0066086315,0.07531489,0.013841744,-0.02943959,-0.006808547,-0.0034709214,0.03277968,0.007635833,0.046643384,-0.013386083,0.017633468,-0.04281265,-0.03604773,-0.007160727,0.08178306,-0.03320543,-0.055540044,0.03066691,0.0010502752,-0.066783994,0.06442529,-0.067332275,0.02253078,-0.08816207,-0.11058917,-0.008208559,-0.012282602,-0.01233472,0.049506288,-0.023708448,0.020330096,-0.042167842,0.03545099,-0.03786438,0.0091195665,0.0134010585,0.07322872,0.055904202,0.07023892,0.021893892,-0.007976631,-0.0094502345,-0.012051469,0.049218126,-0.013590889,0.032524515,-0.021666558,-0.009520889,-0.08447231,0.084801994,0.09722333,0.01385588,0.0804086,-0.004238396,-0.00069885456,0.04620987,0.0066191875,-0.093279116,-0.031986598,-0.015730657,-0.019236203,0.13047454,0.041387163,-0.012598563,0.032889675,-0.01626251,0.045803513,-0.028816666,-0.03396796,0.11592192,0.027042944,-0.047203843,-0.065830894,-0.0090730935,0.009959165,-0.00028998312,-0.0009112025,0.10042529,-0.029765738,-0.018635144,-0.12845203,1.582959e-33,0.058583003,0.03184788,-0.07918378,0.029364107,-0.026922503,0.0046448414,-0.08735234,0.05531581,0.017188257,-0.03333479,-0.009435023,-0.053599678,0.037401095,-0.06664929,-0.036475707,-0.057247836,-0.032881882,-0.039877616,0.055174686,0.021953883,-0.013741688,0.024974264,-0.081319496,0.04837758,0.087736696,0.06565229,0.007588137,0.0037842894,-0.007425108,-0.02611251,0.05720384,-0.051344667,-0.09320471,0.024858119,0.001431932,0.0020275158,-0.043279756,-0.0046282476,0.011115484,0.00041833587,0.046226695,0.053675905,-0.012888156,-0.056531,0.081783295,-0.039545212,-0.024227401,0.071318105,0.023839299,0.069946796,0.012615047,-0.030756764,0.110622995,0.011056747,-0.08844875,0.057331305,-0.013192363,-0.036710065,0.078724265,0.048491362,0.07267572,0.060298014,-0.07512333,0.04363672,-0.06759069,-0.004102133,-0.010556463,0.008751616,0.006082776,0.06957663,-0.108069316,0.060003355,0.03989273,-0.011562865,0.033045843,-0.033624575,-0.06335442,-0.041744113,0.045621853,-0.030076785,0.030996429,-0.024716731,-0.028462112,-0.06304589,-0.103084765,-0.010625419,-0.011674271,-0.09639054,-0.007911617,0.03358913,0.064916044,-0.094852164,-0.05009831,-0.031853214,0.041009102,-2.3893717e-33,0.10740645,-0.08891913,0.036852885,-0.038492467,-0.006574371,0.04634809,0.017911198,-0.010931945,0.004096817,-0.053802565,0.038282573,0.025720712,0.023879822,-0.057224803,0.04613748,0.07751113,0.05102732,-0.0027902077,0.010881596,-0.04493611,-0.037830517,0.11962404,0.022675065,-0.0014725548,0.037028413,-0.01026697,-0.02956186,0.021565758,0.15423073,0.053066228,0.004611126,-0.030518053,0.013652406,0.0011151527,-0.022464182,0.030865572,-0.077127665,0.044548277,0.032289613,0.016104387,0.062028565,-0.011681362,-0.042353455,0.07450246,0.040332243,0.102235004,-0.072931275,0.011976647,0.020791335,-0.06610521,0.06306026,0.003495032,-0.037914503,0.016626174,-0.0019740309,0.040291347,0.046972357,0.0052172695,-0.020605627,0.024942817,-0.061790034,-0.07540476,0.043143835,0.034547694,-0.019898245,0.014489465,-0.049949974,0.08745358,0.0017453432,0.019853598,0.09825641,0.017190393,-0.0138568,0.04040691,-0.08699693,-0.06868166,-0.007500848,-0.042901866,-0.033302426,-0.05114796,0.03144987,0.04275273,0.016533233,-0.06297819,0.024589827,-0.0803668,0.043662254,0.09038133,-0.07162221,-0.0010281035,-0.007971081,0.014840953,-0.0066255704,0.019506216,0.05723909,-4.3292136e-08,-0.027502038,-0.07759327,0.06890794,-0.052768517,0.013010767,0.029022515,0.1155023,0.04128178,0.013577165,-0.08251118,-0.036149435,0.111774154,0.0052064704,-0.016437843,0.076801404,0.039414495,-0.07522115,0.0005679582,-0.042467818,-0.027731879,-0.04953223,-0.04798726,-0.15474615,0.04315555,-0.056410093,-0.036381844,0.048922803,-0.025245003,0.05241687,-0.074130274,-0.04524538,0.06618679,0.022496745,0.0058650943,-0.078092635,0.0020163206,-0.081895545,-0.04384122,-0.015091904,0.020439198,0.021215841,-0.0024480456,-0.064521626,0.014779048,-0.0353129,-0.0056613265,0.013180594,-0.023390464,0.044291895,-0.007065047,0.07960615,0.015326313,-0.004349697,-0.06725007,-0.1188916,0.07010561,-0.02043622,-0.00040103993,0.015473545,-0.050557896,0.016130822,-0.0029594202,0.14637339,-0.018985305 +1.14.19.53,A cytochrome P-450 (heme thiolate) enzyme found in vertebrates. The enzyme is also active with retinal and retinoic acid.,384,1.0,-0.052351832,0.0039489656,-0.01836263,-0.025222147,0.010335751,0.061291266,0.017577525,0.08509653,-0.015735328,0.07306469,0.0089591425,-0.05334116,-0.05382493,0.09221259,-0.025720226,0.022454767,-0.023787456,-0.039591547,0.029192269,-0.07952788,0.014941058,0.025010744,0.021913275,0.021510912,-0.047604818,0.0028394405,0.07163685,0.04126479,-0.04448434,-0.034410905,-0.112570405,-0.038037617,0.0098501025,0.0032957909,0.009239747,0.09698013,-0.08810888,-0.040875953,-0.043411437,0.0023671996,0.04735351,-0.04546751,-0.10647677,0.0454764,0.024075376,-0.03692393,0.0039459234,0.0046106726,-0.004372933,-0.032913104,-0.044697016,-0.049003534,-0.05959006,0.0079287365,-0.029336829,0.05393292,-0.024205538,-0.0020649205,0.029334912,-0.028024748,0.012604164,0.015378531,0.004715073,0.022781521,0.017401258,-0.020677978,0.013650194,-0.049036,-0.012170245,-0.10706366,-0.02101454,-0.08407288,-0.018383767,-0.007944656,-0.117314406,0.0129206255,0.013486515,-0.030856252,0.006692811,-0.03797669,0.06637256,-0.012469925,-0.048662744,0.07907294,0.12900731,0.0043340106,-0.017175838,0.050374083,-0.051616244,-0.049045555,-0.020569658,0.03010296,-0.1105591,-0.06280339,-0.10137218,0.010008112,-0.018560087,0.044780724,0.020839341,-0.03064374,0.05917954,0.04210976,0.012205746,-0.07521191,-0.077904955,0.00464483,0.014198188,0.06452859,0.071943186,-0.069962956,-0.06008464,0.028745407,-0.012280994,0.019386359,0.031165306,0.08403871,-0.05286288,-0.04361774,0.047181465,-0.014009313,-0.029719938,0.015321261,0.081545986,0.014192847,0.022810876,0.019146744,-0.082245916,1.2835361e-33,0.080492675,0.03970044,0.004106152,-0.022229036,0.007954937,0.026993971,-0.025620563,0.119199924,-0.09293205,-0.027027588,-0.03277161,-0.06786553,0.015596089,0.0059130117,0.025062589,-0.025406336,-0.02812592,0.04383154,0.02627617,-0.05322204,-0.06801759,0.015021026,-0.016518662,-0.0047793053,-0.033937316,0.06880756,-0.030958306,-0.0033841277,0.036372088,0.014971485,6.367696e-05,-0.03074615,-0.0052357987,-0.026010033,-0.008161027,0.00079621293,-0.001424564,-0.016949998,-0.04687481,0.036734536,-0.010933293,-0.026859412,0.06850382,-0.10570699,0.052819196,-0.039959736,-0.15850267,0.054689825,-0.043911077,0.033440933,0.07368545,-0.072374105,0.09114446,-0.012081315,-0.07245182,0.05041722,-0.024568923,0.068723835,0.014237784,0.018258646,0.1254619,0.07196885,-0.053506862,0.09951805,0.05898918,0.033369903,-0.042818297,-0.03163446,-0.06464648,0.10001489,0.006275651,0.03396361,0.055941217,-0.07549677,0.04514269,-0.005523016,-0.0195235,0.0973866,0.005651034,0.02031511,0.0066948473,-0.032241367,0.04081432,-0.011252446,0.019544555,0.00072048185,0.10246194,-0.017544264,-0.0101537565,0.023621937,0.06839433,-0.10318881,-0.019201767,-0.048274036,0.036114153,-1.6624978e-33,0.061830286,-0.03285148,0.04987804,-0.08954038,-0.050363693,0.061928667,0.02524211,-0.008899077,-0.02685859,-0.05271953,0.10129333,-0.024280896,0.01708808,-0.035780292,0.0076652267,-0.02248651,-0.03889606,0.0011464322,0.018732028,0.0042093247,-0.057460498,-0.03211569,0.034119956,0.0001872209,0.06892144,0.04679067,0.0065743867,0.019867588,-0.013268339,-0.013712832,-0.08333557,0.076062426,-0.03810973,-0.043465473,-0.012332102,0.0388046,-0.013049058,-0.025836654,0.008017458,0.081081435,-0.008311509,0.06321249,0.069784455,0.05089904,0.004644254,0.1328752,-0.042285174,-0.026529517,-0.019914243,-0.049940005,0.02976387,0.017507069,-0.062239703,-0.0097117685,-0.026351642,0.04259072,-0.040661108,0.016491424,0.0065744314,-0.08777415,-0.015803851,-0.06789737,-0.0061689024,0.04999813,0.035531055,0.07194572,-0.03152588,0.06176025,0.03810876,-0.015773913,0.08665604,0.020326817,-0.009187001,0.08470683,-0.031190744,-0.0018514663,0.031165404,0.026048617,0.051802836,0.027482854,0.04619298,-0.008484273,-0.098310284,-0.015445829,-0.01613899,-0.109205015,-0.061839275,0.10188311,0.057136666,-0.069078036,-0.07661146,0.0557593,-0.07581572,0.02693826,0.06433844,-2.7077254e-08,0.04876097,-0.08669055,0.031442985,-0.030744094,0.06938162,-0.012494409,0.05758815,0.033422027,0.04269436,-0.047042184,-0.025137547,0.011306277,-0.013238685,0.011805291,0.0335359,0.034964,0.021825401,-0.0023418786,0.040191706,0.017187748,-0.06919005,0.005817626,-0.025943901,0.046236463,-0.0073834634,-0.043298434,-0.02229284,-0.0213881,0.011600885,0.009380563,0.034997646,0.042252377,0.034590397,-0.0050463774,0.02191533,0.021822104,-0.038570292,0.004925025,-0.060770694,0.00599401,-0.02498816,-0.06604524,-0.038939945,0.00010441297,-0.009803071,-0.036583133,0.089807585,0.005981934,-0.008412878,-0.039984573,-0.104121394,0.02019714,0.018294327,-0.104306936,-0.13948771,-0.035014283,0.10440575,-0.06259273,-0.07931679,-0.118391566,0.09327476,0.05420215,0.1780652,0.007544493 +2.1.1.346,"This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions [2]. ",384,1.0,-0.0013713723,-0.05386548,-0.036646254,-0.030344969,0.017606337,0.095402695,-0.109384015,0.023299737,0.053599037,0.014562921,0.044131517,-0.024654405,-0.043199364,-0.015317785,-0.022106854,0.102368064,-0.13961226,-0.05765853,0.037904963,-0.01773411,0.03562825,0.11407769,-0.034355443,-0.004463577,0.058218814,-0.0041996017,0.025364084,0.006445952,0.032658227,-0.050109345,0.010536763,-0.06271193,0.07526412,0.016842412,0.029061312,0.06975251,-0.007053617,-0.02798015,0.0698643,0.06296065,0.05427684,-0.020641916,-0.023255313,-0.036820292,0.00023271501,-0.038804654,-0.003131414,-0.011995565,0.007303413,-0.013298425,0.048138384,-0.13640775,-0.026309803,-0.014245796,0.055756774,0.072220586,-0.04020657,0.027952338,-0.002838662,0.022563288,0.09288604,-0.030368935,0.0058333767,-0.027486261,0.10999818,-0.06178008,0.055490267,-0.036543604,0.04519293,-0.0909609,-0.058527667,-0.06841627,-0.065712005,0.08830391,-0.052834943,-0.02511162,-0.002213107,-0.029171882,0.044141766,-0.061396364,-0.014632643,0.018549222,0.005415417,-0.0064742197,-0.0038610462,0.023459187,-0.029853525,0.04497475,0.011153937,0.03786817,-0.046020143,-0.0760099,-0.024398845,-0.03199259,0.023654409,-0.0018038516,0.053160895,0.05040027,-0.010082508,-0.044828698,0.073202886,0.08411097,-0.14907803,-0.02526772,-0.015597907,-0.009299755,0.03349956,-0.029101953,-0.06511641,-0.041221295,0.04363815,0.027774926,0.030237813,-0.03489022,-0.0015421452,0.04559178,0.031914536,-0.02717363,0.005252163,-0.020435676,-0.033623382,-0.037941817,0.06279244,0.04035426,-0.016414635,-0.029274164,-0.12986726,3.9054532e-34,0.08574879,-0.0070825918,-0.03372502,0.00931465,0.007145322,0.016620284,-0.054851726,0.04637753,-0.039361805,-0.057110474,-0.094623916,-0.062138434,0.0008687254,-0.034397427,-0.039778084,0.019119186,-0.05076548,-0.010808538,-0.0036320484,-0.06190566,-0.05538307,-0.06491756,-0.021826027,-0.03491877,0.007017773,-0.04015642,0.0027714649,-0.019599643,0.05847758,0.008699136,-0.08694806,-0.031958323,-0.034653172,0.085928224,0.036388755,0.03266592,-0.02107137,-0.013001495,0.05412025,0.10754739,0.113355964,0.016577888,0.01611056,-0.03293072,0.015625237,0.043237284,-0.08759475,0.023023143,0.0017710513,0.03897806,0.028824737,-0.04147312,0.063172236,-0.0027500496,-0.09284773,-0.023317045,-0.05263981,-0.1100448,-0.07464552,0.110582955,-0.042136244,0.011773637,0.016678317,0.06298254,-0.016050115,-0.016356964,-0.11101174,-0.085187756,-0.012577307,0.07257163,0.018644655,-0.015094241,0.1471156,-0.014133135,0.019773385,-0.0006164659,-0.09469764,0.100978285,-0.048647247,0.047937393,0.012437007,0.003282726,-0.037266877,-0.04032589,-0.0028175672,-0.025304427,0.060063254,-0.10506035,0.0053240163,0.08252773,-0.009645315,-0.04973502,-0.026445339,-0.017307201,0.03536592,-1.8343736e-33,0.020547353,-0.032897286,0.043324098,-0.088656835,-0.023257893,0.08407183,0.043384127,-0.035375137,-0.024860272,-0.026731705,0.08686366,0.06717815,0.042582236,-0.09108484,0.061904006,-0.035108466,0.006348019,0.051541843,0.04459727,-0.035004742,0.068249725,0.011721408,-0.03023632,0.06638055,0.054302912,-0.039834306,-0.022463884,0.044985082,0.04465784,0.018682536,-0.05146396,0.009773984,-0.030117743,-0.0158514,-0.025373597,0.03965505,-0.05376542,0.01986099,-0.012195218,0.014817545,0.02415922,0.08060422,-0.037538685,0.08241224,0.034326132,0.07958025,0.0022398813,-0.0040963916,-0.03159151,-0.06148501,0.08117523,-0.069673054,0.06387491,0.05134832,0.023729477,0.061076395,-0.06928498,0.049537305,-0.013887076,-0.012238826,-0.05229529,-0.06792202,-0.0499056,-0.005126874,0.0385183,-0.04203554,0.0015471077,0.0047717514,0.027796768,-0.024787765,0.070126325,-0.036670715,0.024771139,0.03417331,-0.08201876,-0.03054562,-0.076344386,-0.04865422,0.004501475,-0.059807334,-0.04527041,0.02475791,0.024853094,-0.060397077,0.05996656,-0.00043338715,0.032821514,0.12568098,-0.014360367,0.057855748,-0.06243958,0.0574784,-0.079021394,-0.007853678,0.020856163,-4.3115623e-08,0.002206134,-0.119320415,-0.0016392668,-0.003870131,0.01785855,0.08623294,0.010554383,0.07386515,0.071133025,-0.0107465,-0.018861268,0.013228392,-0.018184403,-0.0056827376,0.032993555,0.028925471,-0.0034002992,0.1072526,-0.008017633,-0.0313652,-0.08337292,0.030985206,-0.048126664,0.0050344397,-0.054458223,-0.00067926914,0.021627946,0.1550888,0.04154398,-0.05634256,0.09138202,0.0024187048,0.038592055,-0.034716096,-0.11291847,-0.009285311,-0.0010335894,-0.02764459,0.024043413,0.063280255,0.029246759,-0.024893073,-0.016704047,0.052863557,-0.040609308,-0.01704167,0.032923177,0.050868627,0.008525737,-0.027818823,0.041161604,-0.012544104,0.036450356,-0.05494836,-0.015848674,-0.03881292,-0.035183586,-0.0025562108,-0.010272992,0.008518168,-0.010431808,0.05190769,0.13916308,-0.032419737 +2.1.1.347,Isolated from the bacterium Herpetosiphon aurantiacus.,384,0.99999994,-0.07168087,0.022292994,-0.07056518,0.004905471,-0.036368936,0.034221753,0.011758656,0.055720057,0.0053852727,0.035711,0.012731792,-0.08056944,-0.0073211356,0.062048033,-0.07320638,-0.00421641,-0.037380733,-0.029102257,-0.015480688,-0.0003970297,-0.007890496,0.0822473,0.007383667,-0.03764311,0.043041836,0.033436652,-0.04628067,0.04583371,0.028150413,0.0011020614,-0.06782109,-0.05952694,0.03167438,-0.04811836,0.08207946,0.05112286,-0.0426574,0.0121989595,0.13563456,0.022639418,-0.02162432,0.044494435,-0.02587782,0.015427399,-0.023045085,0.032312892,-0.07493104,0.026460988,0.07607523,0.0160272,-0.0062707085,-0.020982495,0.0039790547,-0.0036461982,-0.08323505,-0.07070697,-0.009618272,0.01344464,0.010429869,-0.04760498,0.09833382,0.015298821,0.049556185,0.06949534,0.0019617188,-0.0040285615,0.023846224,0.008210217,0.10288853,-0.020499082,0.057206262,0.008431832,0.02839204,0.06967347,0.012523282,0.058239777,0.03546454,-0.023488551,-0.0044141016,0.036628846,0.02469326,0.026709551,-0.013789626,0.059082787,0.00981094,-0.012916932,0.04574138,0.008897009,-0.036710557,0.03229134,-0.036443446,0.0027195555,0.014410456,-0.11462211,0.009762922,-0.028715212,0.020375624,0.006321297,0.055716448,0.0043066926,-0.020294774,-0.025202358,0.023204805,-0.0639457,-0.03377854,-0.0041831904,-0.06360916,-0.09188406,0.10006461,-0.007684048,0.0035482238,0.017313674,-0.0997395,-0.052737925,0.080726296,0.076673925,0.039819837,-0.06251116,-0.040013753,0.00269118,-0.018533459,-0.11287355,0.07664084,0.0029644377,-0.036655635,-0.012452473,-0.054937795,8.5248853e-35,0.021115715,-0.0351726,0.04375735,-0.06657108,0.06408212,0.08186928,0.047513213,0.00033179997,-0.09601441,-0.00012839216,-0.10408057,-0.023929076,0.06581301,-0.037472118,0.020613015,0.03339102,0.036147255,0.00019306893,0.087685145,-0.039125107,0.03235644,0.11278859,-0.0040663253,-0.02297638,-0.0037873802,-0.00034002267,-0.0005638998,0.0033954163,0.053253435,0.005812735,0.018307898,-0.09414194,-0.06874146,0.046832137,0.022814024,0.026028395,-0.112582065,-0.05259088,0.012824382,-0.018138494,0.07009903,0.015097638,0.038690526,0.02103249,0.046909235,0.014630307,-0.09338062,-0.044225715,-0.001820517,-0.007979378,-0.07416092,0.052704297,0.08791365,-0.09004777,-0.05668894,0.015848191,0.05860351,0.022828605,0.005241045,0.067688316,0.046102185,0.13630691,-0.03273388,0.051249754,0.078192875,-0.009392397,-0.07137332,-0.045928746,-0.046358626,-0.04024065,-0.021280892,-0.045949902,-0.02875629,-0.060739107,-0.025477942,-0.00774548,-0.013577777,0.004189306,-0.090540975,-0.10786483,-0.073134996,0.0049784877,0.065086834,0.029947605,-0.040307354,0.08164843,0.0196164,-0.022175517,-0.01611767,0.07941457,0.08744285,-0.00053251145,-0.06500532,-0.020028166,-0.04288105,-1.8035928e-33,0.0809238,-0.02443382,-0.02390859,-0.056960046,-0.059981093,0.12201893,-0.018186152,0.11653885,-0.033960134,0.004557597,0.03721836,-0.013035014,0.025492601,0.0042541525,-0.010661348,0.06180675,0.09145366,0.0974228,0.021425901,0.041342955,-0.066513866,-0.01823736,0.04470353,0.012718561,-0.047324426,0.03255366,0.07350739,-0.01948341,-0.03575098,-0.015189124,0.010161529,0.046687666,-0.07028565,-0.107547686,0.01741063,-0.020820804,-0.061692625,-0.14029698,0.061781883,-0.033736486,0.022843298,0.02582486,0.0017062834,0.046041694,0.053873003,0.07640587,-0.047297813,0.06786461,-0.040382087,-0.005803356,0.012951686,-0.010262544,0.027321098,-0.0075028236,0.05149467,-0.059415992,0.029025307,0.025537416,0.022050885,-0.02791916,0.052800704,-0.055730145,-0.0437575,0.017258627,0.058042023,0.06270013,0.010655819,0.0003555908,-0.08286,-0.06819564,0.024660438,-0.008624479,-0.02170531,0.05812946,-0.053176176,0.055118788,0.02745313,-0.091779985,0.11933531,5.7364316e-05,0.03345466,0.0031076092,0.03645475,-0.06668634,0.02379681,-0.12468842,0.013645397,0.010673764,-0.026163328,0.0018491739,0.026158648,0.022046346,-0.06471749,-0.075562395,0.113641344,-1.8998664e-08,0.1475503,-0.024478454,0.04094887,-0.013424364,-0.018970974,-0.048324276,0.048801266,-0.04369487,0.03961114,0.026461255,-0.03683796,-0.05930373,0.023570377,0.0050884425,-0.0039644847,0.005920002,-0.01260841,0.024540436,-0.024143022,-0.008769429,-0.09834787,-0.015752755,-0.022893833,-0.022729134,0.0031804636,-0.0652359,0.116126254,-0.051843338,0.051599,-0.0662561,-0.068041965,-0.016928226,-0.0453653,-0.07490357,-0.05771551,0.027639767,-0.0756865,-0.0070041553,-0.0021537964,-0.046499595,-0.037088066,-0.01036584,-0.033746194,0.008386588,-0.012468732,0.0056879004,0.008175274,0.0050761593,-0.051008593,-0.05806573,0.0048845178,-0.023693325,0.056563355,-0.053227387,-0.11073429,-0.033656277,0.046273973,-0.042235192,-0.08823553,-0.011932412,-0.04930646,-0.023611741,0.104769506,0.06739427 +2.1.5.1,"This enzyme was characterized from the bacterium Sinomonas sp. No.22. It catalyses a cleavage of a methylene bridge, followed by the transfer of the methylene group to tetrahydrofolate. The enzyme is also active with (+)-episesamin, (-)-asarinin, (+)-sesaminol, (+)-sesamolin, and piperine.",384,1.0,-0.058575585,-0.017861303,-0.10703963,0.015748661,0.044927545,0.06231327,-0.05222404,0.022541394,0.004801892,-0.02387325,0.04371567,-0.097385466,-0.0456682,0.056766566,-0.07738999,0.052876186,-0.112948135,-0.02943896,0.048917957,-0.0053628744,-0.001136732,0.040044777,-0.0048001963,-0.031500034,0.024806628,0.0508069,0.032784324,-0.07118779,0.020613141,-0.038630433,0.013279047,-0.028321382,0.04563632,-0.061206385,0.056555115,0.042957295,-0.010693792,-0.053170573,0.08285656,0.016879115,0.044803735,0.032584574,-0.010341462,-0.07600846,-0.054258425,-0.010624654,0.10053514,-0.0055489005,0.018204337,-0.027620919,-0.032891624,-0.046541974,0.012034508,0.05889686,0.0027881863,0.037811592,0.020346519,-0.040984247,-0.036680087,0.022042617,0.07536682,0.01319101,-0.014843391,0.010834984,-0.01822482,-0.03323322,0.049811043,-0.045658465,0.017122997,-0.023582472,-0.06878771,-0.044677462,0.040116195,0.07353238,-0.01587255,0.00047218698,0.04334098,-0.020659855,0.056693915,-0.0044138273,-0.02674735,-0.04098942,-0.025482003,0.06469214,0.070924975,0.03398591,-0.03641449,0.056395598,0.13169694,0.029315818,0.023582837,0.054869875,-0.047189187,-0.057698693,-0.046596482,0.035577115,0.005053038,0.034163307,0.018032266,-0.013110988,0.032892585,0.09655608,-0.06672778,-0.11277258,-0.050302513,0.050624903,0.008292571,0.078857586,0.047265675,-0.02079176,-0.005729549,-0.025959557,0.049685586,-0.031759888,-0.030139234,0.08368542,0.027280344,-0.037002344,-0.083612405,0.03233449,0.018624665,-0.047875367,0.009662596,0.035120256,-0.063624,0.04531618,-0.11855572,1.1915316e-34,0.07915239,0.0586274,-0.053788897,-0.056707535,0.0722676,0.02523679,-0.06719549,0.046215497,-0.06588317,-0.0780964,-0.08407875,-0.110300355,0.021527275,0.0021902365,-0.014014832,-0.016686054,-0.041610304,-0.029542338,0.04450459,-0.048822295,0.016667169,0.03782749,-0.08088235,-0.01659322,-0.021185938,0.05848496,0.06733975,-0.0063317544,0.0079570655,-0.011258918,0.017903835,-0.09177674,-0.13374823,-0.0018241281,0.056438968,-0.0015756417,-0.029007187,0.021350546,-0.009698733,0.09225916,0.010707865,0.00028656548,0.008979867,-0.005294425,0.027929002,-0.09409819,-0.037424136,0.07579533,0.11208201,0.060447257,0.019486412,-0.05389417,0.06975386,-0.03163168,-0.10213521,-0.00477602,-0.07295235,0.0071729873,0.0004386471,-0.004301341,-0.011293135,-0.049655247,-0.062255897,0.017849814,-0.029825643,0.01602687,0.0029319494,-0.041478943,0.04592731,0.028718384,-0.07498726,-0.032499447,0.020805378,0.05421276,0.021910693,-0.053321034,-0.08791406,0.03700331,0.12063685,0.043891996,-0.05111129,-0.010062982,0.0999997,0.011210943,-0.050986823,-0.024695111,-0.007961618,-0.013518432,-0.014502475,0.07910485,0.043065973,-0.121935174,-0.051300805,0.058745004,0.003916247,-1.1419061e-33,0.066759266,-0.021434514,0.019528193,-0.12460843,-0.086374655,0.038664952,0.0022219047,0.056787357,-0.059381813,-0.033456832,0.10622801,-0.00042694938,0.074601635,-0.03988903,0.031711075,0.01650547,0.037383523,-0.00622418,-0.012632887,-0.026270263,0.049213007,0.012801304,-0.051901683,0.019884864,0.025993291,0.05510632,0.038775943,0.015774768,0.058499936,0.058395963,-0.007037038,-0.04308005,-0.044492643,0.0027380711,-0.007902408,0.10728179,0.013302003,-0.016991027,0.017475575,0.009104995,0.063430026,0.015124131,0.0061118333,0.06521025,-0.003513808,0.08588885,-0.11400691,-0.015055995,-0.046288393,-0.041672442,0.0043099322,0.060240325,0.0019710383,-0.022401867,-0.0019689878,-0.020913804,0.013374993,-0.013606565,-0.08411491,-0.040398102,-0.03779978,-0.045752015,-0.0049517825,-0.024985021,0.06207504,0.055076882,-0.0038872126,0.04754906,0.027840363,-0.08266343,0.062463548,-0.00467794,-0.008338688,0.04913476,-0.047007106,-0.07306458,-0.01847782,-0.05769931,0.037321396,-0.043665774,0.06514318,-0.025922667,0.00089591806,-0.08269503,-0.0071113873,-0.035999477,0.01664654,0.0838299,0.018082593,0.039691932,-0.0025969425,0.0016148379,-0.085947596,0.06663258,0.09473238,-4.1056254e-08,-0.023659313,-0.08501992,0.012991195,-0.03743883,-0.027773062,0.07552039,0.018569348,0.02993331,0.04718751,-0.055384282,0.015169231,0.05182921,0.03707956,0.073846795,0.00045856938,-0.042526513,-0.03649296,0.023589794,-0.015329508,-0.041325912,-0.08175202,0.0037111368,-0.05786924,-0.0010569117,-0.009908708,-0.015370486,-0.024343811,0.06277582,-0.011118739,-0.042423364,-0.07829915,0.020368334,-0.009889126,0.051121164,-0.054502763,0.07849189,-0.0010917244,-0.07918162,-0.038840707,0.036066983,0.07104905,0.047526997,-0.080653615,0.022964459,0.08071783,-0.023136571,-0.03788454,0.046498667,0.022439128,-0.022422655,0.13356212,-0.033546865,0.07130243,-0.08945104,-0.1477131,-0.031520933,-0.03467059,-0.06375794,-0.03135161,0.020006575,0.048661973,0.007890455,0.12052109,-0.0273149 +2.3.1.266,"The enzyme, characterized from bacteria, is specific for protein bS18, a component of the 30S ribosomal subunit. cf. EC 2.3.1.267, [ribosomal protein uS5]-alanine N-acetyltransferase.",384,0.99999994,-0.01728261,-0.04668946,-0.09581526,-0.033726223,0.054389786,0.037603807,-0.06931772,0.0042237793,-0.011383571,-0.06497325,-0.006663936,-0.018179236,-0.028001385,0.050449334,-0.035555974,0.058476176,-0.086977296,0.0128130065,-0.029251438,-0.03857053,0.029435055,0.119158186,0.0055257175,0.014626895,0.0054366165,-0.040533166,0.04990083,-0.0049816845,-0.021101307,-0.040263046,0.060095675,-0.023055196,0.07428344,-0.058041893,0.07420797,0.04987757,-0.038356666,-0.02583715,0.055387393,-0.021216368,0.04550134,0.017860642,-0.0013445064,-0.03801333,0.038677014,-0.007148857,-0.029909894,0.14997692,0.096433036,0.026176564,-0.02649141,-0.10978093,-0.041513722,0.014121057,0.048650093,-0.0072618183,-0.044461757,-0.06607993,0.04325701,-0.0034824233,0.027411925,-0.0021387779,0.0036547515,0.0016205074,0.095232286,0.032906163,0.04334709,-0.09295361,-0.01763901,-0.018619582,-0.030844936,-0.09454851,-0.039785217,0.056404058,-0.037566643,-0.026904467,0.013996895,-0.013128856,0.035163023,-0.031937752,-0.038148433,-0.07262842,0.019557083,0.062789805,-0.050454114,-0.008646001,-0.0018150442,0.03704037,0.017911866,0.08810462,-0.03662273,-0.057455204,0.025138622,-0.07437858,-0.060050894,-0.0024383692,-0.016150542,0.06844352,0.07457216,-0.051235043,-0.018791031,0.027344126,0.019403601,-0.04308416,-0.045281537,0.013828426,0.023342725,0.077155694,0.016358871,-0.019934263,0.05103607,0.064049326,0.013665823,-0.046734873,0.031597186,0.02861608,-0.008657497,-0.08253263,-0.011991993,0.017351042,0.022466654,0.039307892,0.04349534,0.06652564,-0.05659019,0.036224198,-0.116502635,-8.185635e-34,0.062250096,0.0077648517,0.045918174,0.023412744,0.010227796,0.011327923,-0.05189064,0.00541885,-0.06375882,-0.011123956,-0.091686375,-0.07749163,0.100568935,-0.051780388,0.09546791,0.036135957,-0.008709306,0.0074546635,0.015061969,0.013025565,-0.018107688,0.08190053,-0.065461606,0.0023012292,0.07081191,0.012975615,0.013334241,-0.0008737798,0.05014678,-0.027979413,-0.0228701,0.0031787823,-0.11385296,0.011855718,0.055936094,-0.025084164,0.02405306,0.004344911,-0.019871177,-0.027575122,0.10782773,0.07323915,-0.036685925,0.048791472,0.09421888,-0.053504203,0.011005214,0.03705034,0.016294127,0.056372497,-0.005726781,0.014359601,0.103818685,-0.061294246,-0.011591615,0.05063608,0.0157821,0.08935571,0.023916684,0.058722395,0.053049624,0.033412594,0.0061382414,0.022878574,-0.017337412,0.037300915,0.007280653,-0.08281042,-0.014915044,0.035523087,-0.09911646,-0.017337365,0.07763219,0.025363766,-0.017726531,-0.056759115,-0.045829132,-0.049363744,-0.013373804,0.028541798,-0.08663437,-0.00045063323,-0.009759918,-0.0644649,-0.060943324,0.017812239,0.027122237,-0.06326695,-0.03284892,-0.0423571,0.11283897,-0.11302998,-0.09922335,0.115359396,-0.012322111,-8.202928e-34,0.0710032,-0.11375352,0.08157901,-0.06931319,-0.08680887,0.014249738,0.02779741,-0.029171597,0.037457578,-0.0021375665,0.11048497,-0.006225792,0.0084977625,-0.06822167,0.038260847,-0.015690226,-0.026884418,0.081331976,0.0006085447,0.02336295,-0.013132087,0.09194613,-0.0017451395,-0.004198757,-0.0030475338,0.03946988,0.0010520697,0.08436733,0.06200144,0.0042948197,-0.039730597,0.058550723,0.00568949,-0.037908286,-0.11043301,0.021453993,-0.012407491,-0.022425165,0.07072843,-0.0030714332,-0.017755486,0.11488056,-0.040416613,0.1126658,-0.018152038,0.10225395,-0.021282978,0.009547383,-0.07371218,-0.070472814,0.024848973,-0.053116303,0.003905702,0.050491735,-0.025540967,0.0028742235,-0.015626324,0.06389498,0.035040114,-0.07403596,0.012469731,-0.017126761,0.045202468,0.002159982,0.018887404,0.06273923,-0.07691527,-0.00045427107,0.04222544,-0.0098411245,-0.023797968,-0.0016054517,0.012005827,0.07628919,0.017823508,0.0053697666,-0.051843524,-0.039262135,0.008882806,-0.052651078,-0.043953277,0.058480613,-0.038282245,0.036397528,0.023048824,-0.07440233,0.023866761,0.08727372,0.0008889218,0.05376713,-0.059356794,-0.04739417,-0.05083226,0.0517168,0.0032819412,-3.3126682e-08,0.04742438,-0.008441242,-0.021808356,-0.06812346,0.018304033,0.06264549,-0.030265046,0.02085144,0.058065567,0.038120713,-0.029030617,0.019192697,-0.060192294,-0.04802979,-0.0047967243,-0.0076909005,-0.0639229,-0.0030076678,-0.0301409,-0.013681577,0.041271422,0.061527982,-0.061179284,0.032665957,-0.02595757,-0.06397276,0.002696484,0.023806766,-0.016361015,-0.08909939,-0.050458863,0.005084174,0.017920928,-0.023784963,-0.056336004,0.061564565,-0.03332854,-0.026442511,0.022025261,0.084518574,0.048612263,-0.1387596,-0.119455524,-0.048174042,-0.018267652,0.011456137,-0.04073087,0.06845934,-0.0415723,-0.018837523,0.015465128,-0.03782178,-0.018973982,-0.042925593,-0.07773754,-0.005479574,-0.039075583,-0.13359393,0.039447818,-0.007147903,0.05420776,0.024433453,0.11367801,-0.09520961 +2.3.1.267,"The enzyme, characterized from bacteria, is specific for protein uS5, a component of the 30S ribosomal subunit. It also plays a role in maturation of the 30S ribosomal subunit. cf. EC 2.3.1.266, [ribosomal protein bS18]-alanine N-acetyltransferase.",384,1.0,-0.00083546893,-0.06719446,-0.07574247,-0.036025215,0.06461982,0.039937817,-0.052556586,-0.032538112,-0.0012936618,-0.021859018,-0.0039372314,-0.021456007,-0.03755475,0.09513471,-0.027559979,0.020810748,-0.08845501,0.0035747183,-0.038578402,-0.05780723,0.06304565,0.07444441,-0.006614342,-0.009097889,0.021519642,-0.010508436,0.060442794,0.024754366,-0.027954523,-0.08903091,0.035002515,-0.024405448,0.08565975,-0.057247195,0.020110607,0.06790797,-0.036571164,-0.045805767,0.07377092,0.0025718154,0.03508755,-0.019561276,0.0026824016,0.005339332,0.0042313267,0.028389106,-0.01176604,0.1320022,0.07086679,0.058248606,-0.02697895,-0.0722161,-0.033841696,0.017283231,0.024540555,0.018346401,-0.011105011,-0.057594027,0.0066633346,-0.051614203,0.013556734,-0.01273032,0.001244261,0.013886315,0.045359068,-0.023966368,0.04017884,-0.065933116,0.006570182,-0.00762876,-0.00028424626,-0.10069554,0.010386127,0.09402968,-0.020783072,-0.02451466,-0.0031480475,-0.039771862,0.041897096,-0.04589521,-0.024567926,-0.016751675,0.02435376,0.035229683,-0.018146869,0.016628202,0.015075468,0.028458871,0.031433344,0.038205013,-0.0196541,-0.05583968,0.011006339,-0.061113145,-0.05864178,-0.0018788866,-0.012632321,0.07193698,0.0022500516,-0.05728603,0.017194517,0.026884746,0.019732725,-0.017777583,-0.02818308,0.0064395783,0.005581441,0.08865486,-0.032798573,-0.022511663,0.01656958,0.027649984,-0.024535872,-0.032628477,0.072481215,-0.013720082,0.028797789,-0.09347638,-0.028061606,-0.015090465,-0.0013728172,0.03160136,0.050627317,0.08000864,-0.07732597,0.007794707,-0.15106192,-3.8296495e-34,0.02638062,-0.032024875,0.019589087,0.07423002,-0.008432456,0.020014737,-0.020144964,0.010407453,-0.04006415,-0.026353523,-0.10270235,-0.0780638,0.11988797,-0.058890365,0.04466521,0.04247992,-0.02045229,0.0014542559,0.017779903,0.028111517,-0.045597155,0.07375238,-0.056244764,-0.003430882,0.056236785,0.027667822,-0.012218819,-0.025995197,0.045232974,-0.019414652,-0.04327099,0.0013203197,-0.11418389,0.0023206132,0.06568224,0.010968717,0.035946492,0.034056425,-0.005733865,0.03575132,0.09934261,0.040468488,-0.023847947,0.046530157,0.09320055,-0.018290915,0.017863883,0.07923964,-0.04203817,0.035216015,0.04795729,0.008123818,0.112331554,-0.09951802,-0.061060235,0.056647062,-0.01915788,0.07677755,-0.023726054,0.03612313,0.007279944,-0.0011205937,-0.0061737336,0.045925353,-0.024998331,0.039182972,-0.007568797,-0.09525496,-0.014475527,0.12129052,-0.09786459,-0.020015687,0.10256526,0.04504781,-0.011766903,-0.030502174,-0.03383734,-0.030985551,0.015460044,0.023477186,-0.09741933,-0.046622984,-0.041713238,-0.04535069,-0.061560467,0.017408503,0.052586004,-0.0888718,-0.026677446,-0.008573641,0.13258643,-0.117248766,-0.042780977,0.13225888,0.005942744,-1.5598588e-33,0.07453141,-0.11983256,0.05268974,-0.038300574,-0.09336432,0.025556253,0.021805158,-0.019963408,-0.016166545,-0.010733141,0.107473284,0.019979127,0.01224618,-0.03720331,0.011436693,-0.009446614,-0.026787594,0.08106119,0.03388183,0.036008667,0.009999851,0.07696203,-0.017125895,-0.02170036,0.013810154,0.05538183,-0.037320074,0.041389048,0.08160157,-0.020094471,-0.04746526,0.03340623,0.00823565,-0.029409995,-0.11094545,0.03600448,-0.03213459,0.0042437236,0.065071076,-0.010893801,-0.03313639,0.11143611,-0.046142183,0.10929232,-0.04729409,0.091122106,0.02422304,0.056096338,-0.09002141,-0.0978964,0.02076392,-0.08703406,-0.025876371,0.04051604,-0.0716932,0.054876838,0.016106594,0.0540679,0.05382079,-0.012044141,-0.031720947,-0.008600879,0.05469664,0.004688351,0.03368996,0.033610873,-0.034297258,0.02990481,-0.002731777,-0.007563405,-0.020904906,-0.027302666,-0.0021047245,0.05546351,0.014264053,-0.040260002,-0.06836992,-0.039161917,0.006572092,-0.04515376,-0.054513305,0.028168943,-0.06997658,0.004794899,0.015079753,-0.09651907,0.034376297,0.110783674,0.049518507,0.063176,-0.048320934,-0.01567003,-0.078506514,0.043487467,0.013540412,-3.762698e-08,0.045561824,0.025979115,-0.015453756,-0.061824046,0.02749128,0.06425877,-0.015711734,0.048373476,0.095973074,0.045662686,-0.030308016,0.022895474,-0.02826124,-0.0055951583,0.012452331,0.011941949,-0.054982446,0.021219,-0.020480184,-0.015146257,0.0103720855,0.048865486,-0.0743216,0.03882125,-0.034015685,-0.056137968,0.02083507,0.06328986,-0.040476993,-0.10426083,-0.056545205,0.029789593,0.0076990174,-0.023718582,-0.051572084,0.0701173,-0.019065633,-0.038584683,-0.018255504,0.06787601,0.037240587,-0.115639314,-0.11488326,-0.028347956,-0.017861785,-0.0051086843,-0.04672255,0.03707053,-0.024119576,0.0018035524,0.014934638,-0.011520451,-0.020809319,-0.0427576,-0.07617229,-0.0019989552,-0.051490285,-0.13319263,0.03900174,-0.019458376,0.016785072,0.041992985,0.11168716,-0.104774445 +2.3.1.268,"The enzyme, characterized from the yeast Wickerhamomyces anomalus, is responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts. It is only distantly related to enzymes classified as EC 2.3.1.84, alcohol O-acetyltransferase. The enzyme also possesses thioesterase and esterase activities, which are inhibited by high ethanol concentrations.",384,0.99999994,-0.003629445,-0.030187303,-0.1040681,-0.036822937,0.06018866,0.032766767,-0.05788077,-0.013778376,0.044211235,-0.0061985794,0.02157862,-0.0795519,-0.11293037,-0.023723641,-0.08262115,0.042755965,-0.029737517,-0.02285817,0.03137291,-0.09757374,0.05941058,0.03006901,0.07851669,-0.02865279,0.044041026,-0.035791133,0.033521727,0.01644614,-0.023928378,-0.13702771,0.0070725735,-0.04314803,0.040364873,-0.03840229,0.027020235,0.028738165,-0.009252262,-0.07658118,0.076960444,0.040352833,0.034347888,-0.0035552077,-0.038661033,0.01863537,-0.07608365,0.033995904,-0.010903356,0.039020438,-0.022491887,-0.04062514,-0.03810013,-0.05634563,-0.013517148,-0.028468035,0.014378036,-0.053814325,0.03206924,-0.025788195,-0.008573526,0.03394281,0.041799784,0.00420932,0.01625504,0.04133077,-0.037381656,-0.042811092,0.05737851,-0.06016991,-0.041945387,-0.008675697,-0.089106604,-0.09628875,-0.046717327,0.069226824,0.06460998,-0.017408812,0.03323759,-0.06517709,0.018845232,0.016402554,0.023477055,-0.00923598,0.01859172,-0.011821197,0.063982494,-0.079377785,0.0055190288,0.021686751,0.020089535,0.052418616,-0.021182233,-0.03565052,0.039478414,-0.037468895,0.0043976433,0.080298446,0.033969555,0.045182727,0.037978936,-0.030837046,-0.004978396,0.10149571,-0.03295229,-0.031887084,-0.011119702,0.010126618,0.034971137,0.08894796,0.013036272,0.011489322,0.010610108,-0.068971425,0.0076582907,-0.038343906,-0.016957596,0.045368906,0.008431403,-0.026708273,-0.017052842,-0.02500752,0.030806994,0.033597704,0.083583415,0.10375456,-0.031188156,0.057513095,-0.106620975,1.9861103e-33,0.051264837,0.0429373,-0.066457644,-0.007316128,0.030178558,-0.021241024,-0.062566385,0.015604128,-0.052525092,-0.040023547,-0.04907374,-0.013922366,0.004313665,0.021739786,0.044654243,-0.025289424,0.056624882,0.039016336,0.005200957,0.026633183,-0.023904013,-0.05072876,-0.06844768,0.02998759,0.04172356,0.025986157,0.019375205,0.048953183,0.04465275,-0.026793407,-0.0321189,-0.08628411,-0.052656908,0.009570137,0.026627693,-0.029337334,0.04057983,-0.007261182,0.047700718,0.0066326503,0.009704158,0.05164539,0.07724862,-0.04676672,-0.0049187373,-0.02293056,-0.072936915,0.043644276,0.06511911,0.04482518,-0.038557764,-0.04210895,0.17811193,0.00023951051,-0.00068851036,0.04884556,-0.02804747,0.066664755,0.016649382,0.026505725,-0.064729415,0.07514348,-0.020542344,0.03897474,-0.056257218,0.024721986,-0.0086991405,-0.09672556,-0.018098809,0.037226357,-0.09445841,-0.025593186,0.07568879,-0.019595087,0.040065113,-0.04309827,-0.096474394,-0.026291076,-0.032321572,0.006816768,-0.018263344,-0.006731021,0.01095821,-0.043906745,-0.060159244,-0.06661864,-0.075051494,0.034808572,0.040121514,0.051142037,0.05674124,0.00240461,-0.032706637,0.077662945,0.06835335,-2.8668274e-33,0.13186315,-0.052198533,0.06845153,-0.12401142,-0.084899776,0.11653915,0.01615542,-0.024242822,-0.056372683,-0.028194366,0.07193589,-0.024517024,0.009757074,-0.10885557,0.032426167,-0.05387008,0.022105196,0.09508704,-0.0107680755,-0.031291448,-0.004402224,0.05940274,0.018024357,0.00808283,0.04107531,0.024792664,-0.018500142,0.06482031,-0.011047486,-0.007043616,-0.06708469,-0.02255438,0.011564587,-0.025174247,-0.059243344,0.053889964,-0.005186306,-0.0070337835,-0.05878559,0.08315587,0.054359406,0.082477264,-0.039641745,0.050625026,0.014119608,0.07392937,-0.044668682,0.03939638,0.0107257925,-0.0693223,0.043443937,0.04285226,-0.012804874,0.020386951,0.049786083,0.06182791,-0.0010219989,-0.010732283,-0.018698495,-0.031268023,-0.039302908,-0.013122614,0.036932956,-0.029562984,0.062829845,0.015851725,-0.13013014,0.070691034,0.07261529,0.023873702,0.07884748,0.01964767,-0.060140956,0.048214663,0.0023864745,-0.055487823,-0.04201015,-0.096935146,-0.011535079,-0.041277368,0.019640656,0.0065113544,0.011447529,0.0031009892,-0.07259173,-0.050408814,0.02515967,0.02739814,-0.054598078,0.04699739,0.0023844403,0.010837297,-0.109041676,0.10455204,-0.005707428,-3.5859333e-08,0.011457798,0.00666831,0.07073389,-0.03637651,0.0028363834,0.012186507,0.07023801,0.018449763,0.04467656,-0.028925564,-0.09317325,0.07947903,0.07519217,0.0482419,0.045805946,-0.013665521,-0.03483762,0.040366683,0.017940637,0.042773325,0.0026118907,-0.015404082,-0.084214225,0.056761112,-0.059625827,-0.03666389,0.040435087,0.05841389,0.05314834,0.021109523,-0.0867777,0.024931652,-0.011224669,-0.00073674537,-0.07495711,-0.013498344,-0.079661526,-0.08590037,-0.06210906,0.01308758,0.014993308,-0.023715803,-0.096555516,0.042128082,0.0027658956,0.018746302,0.025131762,-0.0060928627,0.015828857,-0.06735697,0.015060337,0.013419183,0.023063602,-0.017837794,-0.099785216,-0.020048395,-0.043684483,-0.05300605,0.015424501,-0.0760373,0.11205921,-0.04881864,0.21992837,-0.031814557 +2.3.3.20,"The enzyme, found in certain bacterial species, catalyses a head-to-head non-decarboxylative Claisen condensation of two acyl-CoA molecules, resulting in formation of a 2-alkyl-3-oxoalkanoic acid. It is part of a pathway for the production of olefins.",384,1.0,-0.048462,-0.06865215,-0.07577147,0.0040398715,0.10203291,0.02200491,-0.101564825,0.021749176,0.11062066,-0.029860644,0.05615208,-0.08095654,-0.06773731,-0.012652636,-0.054359987,0.09095707,-0.1300188,-0.011686611,0.00839919,-0.012580767,0.05743213,0.047500502,-0.012550448,0.043994084,0.004716152,0.0221879,0.06587328,-0.019197961,0.047355413,-0.021305593,0.03674897,-0.0048074545,0.005186345,-0.011594609,0.02741667,0.017991144,0.018474,-0.071744986,0.085942365,0.07826235,0.033240862,-0.013044786,-0.043976486,-0.055901036,0.0015073887,-0.037391663,-0.013340619,0.01399516,0.00869353,-0.015055459,-0.034889765,-0.032094203,-0.0776381,-0.017341187,0.0013705001,-0.045064893,-0.08551779,-0.036879905,-0.019539498,0.016742805,0.09697438,0.020355852,-0.020169407,0.03195345,0.00043106938,-0.061036717,-0.032342907,-0.057509013,-0.0036116592,0.0022869364,-0.0713914,-0.05384729,-0.040319894,0.029082464,0.0360512,-0.00823151,0.012028879,-0.07731963,0.012884967,0.005011526,0.003222021,0.061860804,-0.025302622,0.09583368,0.024709793,-0.015342476,0.032296687,0.034307487,0.033939917,-0.01342584,-0.028692644,-0.026510987,0.005557267,-0.034695573,-0.010647196,0.07655581,0.012452455,0.043347154,0.04216793,0.03823394,-0.080993146,0.041255638,-0.018860055,-0.12598164,-0.12016579,0.03635637,-0.010543334,0.07608638,0.014880193,-0.005823236,0.024282577,-0.052364983,0.02576565,-0.032171123,-0.037751134,0.10927483,-0.009867568,-0.09197131,-0.007419347,0.0013306729,-0.008373749,-0.042486303,0.014012329,0.07589657,-0.03663869,0.02913699,-0.09069054,-5.1274127e-34,0.055123962,-0.0048342235,0.016921658,-0.04918553,0.061924525,-0.014068521,-0.07361305,0.024343122,-0.056106135,0.0011978225,6.956623e-05,0.0032403031,0.0053054956,0.0017219777,0.032393333,-0.07164158,0.01776173,0.042654846,0.0018963462,0.0005639404,0.0048269005,0.061212998,0.011437713,0.0060451017,-0.0031780417,0.0005439732,0.015140968,-0.027833343,0.10024854,0.005461894,0.0019802167,-0.028801637,-0.078900374,-0.015276604,0.026911685,-0.028072113,-0.082496956,-0.06398468,0.0063259783,0.12410677,0.02744803,0.01592134,0.0042554345,-0.011234542,0.0039036889,-0.03995646,-0.03512954,0.11094585,0.0052146143,0.013713381,0.01033264,0.011337817,0.019428492,0.004935023,-0.01598673,0.02701354,-0.119568594,-0.036357056,0.03829584,-0.028342651,0.01737543,-0.018294338,-0.056734823,0.0056290715,-0.062384717,-0.020518463,-0.031371355,-0.003912793,0.040087786,0.02493383,-0.030096242,-0.013277226,-0.0036119495,0.034902085,0.074511364,-0.05025876,-0.04092527,0.0076677846,0.07345155,0.008423155,-0.009863019,-0.012305539,0.06340525,-0.03246487,-0.049108874,-0.0030810584,-0.102926135,0.016158424,-0.04195613,0.0618063,-0.0415378,-0.057377055,-0.035008233,0.03404965,-0.012061595,-2.0899724e-33,0.09007595,-0.19568731,-0.020235788,-0.10434639,-0.040057432,0.047883768,-0.031073768,-0.026911741,-0.009097349,-0.01578387,0.09340531,0.030660678,0.0118461605,-0.039235223,0.047935266,0.0038359156,0.07440496,0.057950653,-0.031164758,-0.038301613,0.025115928,0.054206107,0.038597718,-0.005797054,0.0428388,0.051785458,-0.03077463,0.0662191,-0.0054732077,0.14074014,-0.029543746,-0.041800786,-0.009078603,0.0097843725,-0.033397198,0.09864287,0.046989575,-0.0053416626,-0.01435526,0.07193906,-0.041721895,-0.027827768,0.03318909,0.016891435,0.058796898,0.04941816,-0.08250386,0.011137131,0.026882613,-0.12788878,0.03409783,0.007963518,0.005868433,-0.01753603,-0.04780161,0.104311295,-0.072667606,-0.029566221,0.03838367,-0.08312271,-0.053736374,-0.086489566,0.024371864,-0.046966743,0.041728415,0.047720328,-0.057491,0.014798115,0.044480458,-0.06668069,0.04814067,0.043814503,-0.02347397,0.047688834,-0.019426718,0.009041701,-0.03315689,-0.12009684,-0.020750457,0.012995201,-0.07020294,-0.047802005,0.01936519,-0.048163198,-0.053712383,-0.055591494,0.062394723,0.048005696,-0.039343156,0.029443784,-0.03235596,0.0053506093,-0.020515969,0.092428036,0.0573998,-3.689483e-08,-0.031808477,-0.050574407,0.04405493,0.012558658,-0.042310458,0.018148532,0.00275963,0.015296479,0.03134236,-0.06387582,-0.029913107,0.05531668,0.023055708,0.049619723,0.0758286,-0.00195859,-0.0006052596,0.018264903,-0.019801533,-0.11992078,-0.04714141,0.016821725,0.019794526,0.036616813,-0.043648235,-0.040575076,0.06053081,0.071642555,-0.004929121,0.03374967,-0.0057552587,0.059385244,0.0031924255,0.02286789,-0.008378312,0.00053511444,-0.029279515,-0.05099844,-0.054976303,0.00068854576,0.08522077,0.08354443,-0.085721806,0.029146142,0.091366366,0.03173749,0.019145815,0.056031283,-0.022502627,-0.047752704,0.12760311,0.023583502,-0.018287098,0.072845355,-0.04148792,-0.06581892,-0.04574997,-0.10131907,-0.054743517,-0.04403326,-0.0038813532,0.073988356,0.23049654,0.014316528 +2.4.1.351,"The enzyme, characterized from Vigna angularis (azuki beans), participates in the biosynthesis of rhamnogalacturonan type I. It does not require any metal ions, and prefers substrates with a degree of polymerization larger than 7.",384,1.0,-0.057470083,-0.042914208,-0.12393948,0.016258318,0.043452144,0.039154023,-0.009789742,0.015424775,0.031004563,0.0060502854,0.063591674,-0.019924765,-0.011926505,-0.059595797,-0.085640974,-0.008213492,0.034235045,0.082642235,-0.060637783,-0.0051194164,0.07811823,0.007734082,0.036418706,-0.019001773,-0.00422658,0.034298074,0.04766273,-0.025083154,0.020988317,-0.034296826,-0.031241685,-0.0024746002,0.012143953,-0.06429946,-0.031948615,0.11343128,-0.06658859,-0.076269135,0.058022436,-0.021435786,0.06864555,-0.030483415,0.09581387,-0.015358366,0.034492552,-0.07294279,-0.026736785,0.00410309,0.0044338773,-0.007350434,-0.12295504,-0.055264007,-0.009843246,0.016793532,-0.02485601,-0.020827,-0.1205872,-0.058636066,-0.029636228,0.07341431,0.07252233,0.045501,0.023892116,0.009689945,-0.06695707,-0.051462095,-0.057579532,-0.0063842246,0.054113317,-0.021265745,-0.016989956,-0.0434403,-0.054105062,-0.055019397,-0.009828352,0.035413228,0.06316859,-0.04671151,0.013393595,0.016212378,0.009494926,0.05369038,0.10210916,0.039728012,0.010647641,0.05447592,0.0551515,0.06285071,-0.022252591,0.07414322,0.06359745,0.018615644,0.036059324,-0.051334694,-0.03159286,0.0015441119,-0.0503339,-0.025061848,-0.011155397,-0.008164958,-0.023299301,0.035346717,0.06363911,-0.061912395,-0.07115955,0.015289487,-0.07148074,0.039962217,-0.0014043103,0.0005900156,0.016607765,-0.008974834,-0.06350715,-0.0073316903,-0.0051568868,0.11207686,-0.013664221,-0.062240727,-0.085991204,0.016767263,0.022035101,-0.04542691,-0.012060644,-0.039827373,-0.036529493,-0.017132504,-0.11835247,1.41638235e-33,0.0006559615,0.0041104583,-0.013656969,-0.051933758,0.0066216933,0.016302042,-0.059595928,-0.0327181,-0.038437687,-0.014713726,-0.09511789,-0.055342186,0.002953731,0.021653567,-0.01301115,0.017697323,-0.030838022,-0.04836332,0.06422696,0.012225603,0.04502869,0.026742263,-0.086474486,0.00097099965,-0.05226586,0.04892144,0.02397439,-0.08405565,-0.033702526,-0.011835189,0.07881624,-0.014146715,-0.088703714,0.051014107,0.051740557,0.007069846,-0.0012068074,-0.06842201,-0.036262292,0.055345368,-0.028484454,0.036339905,-0.020259878,0.037366834,0.08352843,-0.037354734,-0.0038603032,0.09378624,0.093343526,0.07823079,0.0038722658,0.07965704,0.1507469,-0.006296461,-0.022790367,0.0070595103,-0.016932113,0.10012928,0.004583418,0.02496626,-0.108006686,-0.057812717,-0.013066567,0.07903292,0.010095356,0.058453288,-0.034284886,-0.107310325,0.01937236,0.05306982,-0.0040296796,-0.029904876,0.03063914,-0.027976232,0.04353619,-0.050140552,-0.035069622,-0.033031337,0.026200892,0.052994393,-0.017765973,0.048840713,0.0121436855,-0.017911263,-0.007921689,-0.022372568,-0.044470314,-0.00031475912,0.08837716,0.008340566,0.09123762,-0.021789864,-0.059686225,0.03835826,0.0070157177,-1.946296e-33,0.061576992,-0.08785555,0.042552575,0.03855876,-0.05109502,0.026431438,0.023050616,-0.00056898384,0.010029303,-0.035484966,0.087838255,0.012494836,0.022599107,0.008269528,0.0034398348,0.035691272,-0.017939664,0.07646357,0.054329824,-0.028573403,-0.08656103,0.06876675,0.039566047,0.000699287,0.061479654,0.02561806,-0.0023243856,0.05686339,-0.018048447,0.04942877,0.017187515,-0.03990873,-0.06261591,-0.088337675,-0.023961399,0.08331988,-0.020428693,0.027711121,0.008584858,0.09303146,0.010257506,0.015115953,0.0221731,0.04360684,-0.000820804,0.027452854,-0.08786326,0.07822633,-0.01699789,-0.09205209,0.016374143,0.0531839,0.004159704,0.034667026,0.04617519,0.061970547,0.017810628,0.054955825,-0.015411972,-0.0077924533,-0.054384675,-0.08255788,0.064784735,-0.036790464,0.042758618,0.09166507,0.12205831,0.039014045,0.053732727,-0.035197493,0.13663277,0.06152776,0.04215543,0.027805863,0.031990327,-0.02962696,-0.018334875,-0.06469633,-0.045166247,-0.047285207,0.101593785,0.0070211254,-0.0033318752,-0.08549373,-0.001341027,-0.03326561,0.05576014,0.07544672,0.0026736748,0.04393451,0.0192927,-0.036836464,-0.096858144,0.019238107,0.055265523,-3.523214e-08,-0.004431799,-0.05984833,0.012417241,-0.0982937,0.04105855,0.037157703,-0.009105194,-0.021858752,-0.0009298456,0.05771571,0.009383209,0.06453764,-0.018213311,0.026195487,0.049864367,-0.017658934,0.014713127,0.07405449,-0.02924603,0.047750205,-0.042729177,-0.016411116,-0.08056891,-0.06944022,-0.047732674,-0.06580067,0.02587727,-0.0044519384,-0.018843338,-0.00050916924,-0.0064754887,0.081198014,0.0475592,-0.0054882877,-0.18975715,-0.0080350265,-0.011188751,-0.057613395,-0.05521012,-0.089563355,-0.030750938,-0.04434069,-0.01770512,-0.018578917,-0.06729873,-0.02617664,-0.01763355,-0.017682146,0.033636607,-0.011721888,-0.017774502,-0.038646314,0.03618927,-0.06486988,-0.05870066,-0.007931424,0.057169918,-0.012602653,-0.000790923,-0.056265265,-0.042834286,-0.018457608,0.15722556,-0.08729926 +2.4.1.352,The enzyme has been characterized from the bacterium Meiothermus silvanus.,384,1.0,-0.13535686,8.4259555e-05,-0.13618271,0.00029808315,0.0400446,0.03485905,-0.10199667,0.11828666,0.08273953,0.0019140395,0.07265372,-0.09809298,-0.025532167,0.048236944,-0.049670815,0.011992266,-0.038863674,-0.038711466,0.036716208,-0.074271314,0.07041761,0.06312229,-0.023444481,-0.014135985,0.040362716,0.012070798,0.042265955,-0.08754128,-0.031964157,-0.043114856,0.0064918953,-0.057629064,0.07614581,-0.059744056,0.07626928,0.038952395,-0.030848615,-0.10313883,0.08590805,0.028371625,0.026476188,-0.0006021164,0.022689896,-0.021553056,-0.09269806,0.018968454,0.07001158,0.03929307,0.0373162,0.012804256,-0.11024403,-0.046991672,-0.032587796,-0.0046062414,0.0127873495,-0.00012914723,-0.0008972033,-0.06470646,-0.035260055,0.07232569,0.05259365,0.03534189,0.08213361,0.030332113,-0.08664428,-0.09825816,0.009954799,0.0085505,0.032617416,-0.06819736,-0.022988139,-0.095872924,0.0005219142,0.030859133,0.010853708,0.0011466001,0.0014336746,0.0021383625,0.05423995,-0.0020491665,-0.07235398,-0.015055599,0.03644091,0.01896828,0.008228611,0.018482529,0.06096161,0.028521849,0.06717341,-0.011249755,0.018279897,0.0031747618,-0.08640124,-0.045776464,-0.05790559,0.04194576,0.004793216,0.019909158,0.028115684,-0.046743523,-0.0032833975,-0.03580546,0.004180576,-0.08243791,-0.094340734,0.004095025,-0.017353004,0.06439737,0.06569768,-0.0059936875,0.033014927,0.04818581,-0.020991838,0.010128594,0.02519097,0.056255948,0.04498908,-0.0545544,-0.020238914,0.036403034,0.019363806,-0.06299136,0.066300325,0.024047615,-0.009699056,0.08529979,-0.10819592,-2.1221034e-33,8.510556e-05,0.0010698555,-0.02231544,-0.06183595,-0.024449985,-0.06281649,0.011308853,-0.015075796,-0.044527136,-0.01796559,-0.081184804,-0.10470232,-0.010151412,0.041755654,-0.008590402,0.020456797,-0.016158847,0.016366892,-0.0151198255,-0.001213759,0.063981466,0.057915904,-0.03735628,0.008437711,0.05374633,0.082531765,0.019792197,-0.08294929,0.071557835,-0.047915723,0.07887343,-0.13100116,-0.10183071,0.019024396,0.08055384,0.055013143,0.0053090355,-0.0033967844,-0.044537287,0.036262646,-0.021595433,-0.0043665026,0.05029037,-0.057842195,0.09857089,-0.024900163,-0.06532664,0.08325386,0.044217527,0.027680267,0.009163255,-0.037064385,0.13336946,0.021376565,-0.054059926,0.08431417,-0.02020637,0.009165104,0.012411344,-0.009466301,-0.06830646,0.003662247,-0.07528833,0.0034536142,0.07388505,0.036543705,-0.06692502,-0.013772789,0.05324335,0.11999596,-0.04901149,-0.037878923,-0.046014953,0.025886472,0.034268852,-0.04881897,-0.11091564,0.015644971,-0.026536502,0.009743527,0.022341391,0.06320994,0.051445793,-0.025894437,-0.05362229,-0.009319511,-0.029515445,0.013023162,0.010709878,0.06043633,0.08293857,-0.022129182,-0.030047003,0.039807722,-0.072267756,-8.65564e-36,0.07509218,-0.09886113,0.075134255,0.0102761565,-0.029163966,0.106785856,-0.009543887,0.1020856,-0.054447707,-0.07129856,0.068800405,0.0221031,-0.012851347,-0.057167146,-0.026211305,0.047602974,0.018420752,0.09477893,0.008070654,0.0068059247,-0.08159594,0.04872807,0.01519062,-0.09512787,0.005361101,-0.018256364,0.04060704,0.019075537,0.026795493,0.009537605,0.019322827,0.00549806,-0.050256837,-0.046729364,0.03469828,0.041556213,-0.06549303,-0.053635057,0.0355858,0.038809843,0.026148828,0.03983697,0.027854836,0.093019515,0.023301203,0.03683708,-0.044615243,-0.010488902,-0.03000896,-0.0020057105,-0.04921169,-0.06252579,0.0225753,-0.0354585,0.0018184192,-0.06100833,0.033154823,-0.00058250525,-0.011499725,-0.012709666,-0.047379393,-0.059359543,0.0286933,0.032213997,0.080976784,0.051391765,0.0014665815,0.03470618,-0.0101757515,-0.023069648,0.093611985,-0.009047998,-0.021637548,0.028072989,0.027039586,-0.06538119,-0.10438051,-0.023662534,0.017000722,-0.05415442,0.051494863,-0.0072148987,0.0009535046,-0.12774585,0.026066305,-0.010157822,0.035915915,0.088706344,0.053130504,0.03225623,-0.046607148,-0.016791224,-0.05790558,0.021960672,0.09747123,-2.3470095e-08,0.022056064,-0.047506638,0.037604984,-0.07201603,-0.008226389,0.036183413,-0.023144113,-0.025992934,0.02615113,0.04387108,0.00026838135,0.038876664,-0.01956411,0.023232494,0.017763223,-0.03976752,0.04391904,0.014380214,0.018510241,0.030285425,-0.04397377,0.020534959,-0.084341556,-0.03512691,0.031201579,-0.0017970155,0.016459003,0.037137676,-0.0063091,-0.031554725,-0.050647914,0.10710857,0.0016238854,0.0024122738,-0.09980937,0.00019894326,-0.044180445,0.012256263,-0.0037333046,-0.0096417405,0.055538252,0.0023846007,-0.057629067,-0.014071108,0.017904283,0.0055843783,0.015658267,-0.047915332,-0.03315567,-0.023858454,-0.010941322,-0.016675962,0.009566971,-0.037103366,-0.13018149,-0.03731536,0.034272663,-0.04079601,-0.0535498,-0.07631493,0.037761293,0.0052628643,0.15595022,0.011776601 +2.6.1.114,"The enzyme, characterized from the bacterium Streptomyces davawensis, has the activities of an oxidoreductase, a decarboxylase, and an aminotransferase. Its combined actions result in the replacement of a methyl substituent of one of the aromatic rings of FMN by an amino group, a step in the biosynthetic pathway of roseoflavin. The reaction requires thiamine for completion.",384,1.0,-0.05980861,0.0053487346,-0.22008418,-0.0055384403,-0.0046017123,0.05942641,-0.07903315,0.072685465,0.03512838,-0.07250591,-0.0404182,-0.020227041,-0.07394013,0.02420648,-0.0669724,-0.0058330814,-0.104581915,0.022539474,0.0055728937,-0.06805973,0.03732758,0.10919878,-0.0065689613,-0.06781125,0.03494397,-0.017651023,-0.0070145535,-0.043303058,-0.043943226,-0.069915876,0.04049347,-0.0016461217,0.07245739,-0.035259884,0.023948582,0.12144791,-0.005914383,-0.061279953,0.02914168,-0.00037474954,0.0015836842,0.008251616,-0.006249177,0.015474269,-0.05890601,-0.031442136,0.040181603,0.064098716,0.025938414,0.0060782335,-0.07446747,-0.04086703,-0.02943692,0.06667132,0.05596064,0.005024195,0.02559969,-0.029136855,-0.0508158,-0.0028727702,0.056904353,-0.0073353597,-0.015207763,-0.024071584,0.0133169005,-0.03814477,0.03033324,-0.091489084,0.017452246,-0.066192836,-0.01111593,-0.048751824,-0.026236342,-0.00497032,-0.062476225,0.019954868,-0.028240321,0.049283292,0.025513481,0.0005375407,0.06412266,0.045106564,0.000551716,0.11148173,0.09066859,-0.0044215145,-0.03902483,-0.016822204,0.043021478,0.060614277,0.033035785,0.001584594,-0.020833338,-0.02394071,-0.0770791,0.007470331,0.039567508,0.00817469,0.030574553,0.06441242,0.004468424,0.033690542,-0.04979423,-0.042642884,-0.107805185,-0.01989433,-0.0044760336,0.08412176,-0.0002600605,-0.0069013415,0.02387383,0.003722852,0.039636265,0.0032364845,-0.034397468,0.0296068,0.050041474,-0.05471753,-0.071303,-0.015352148,-0.01741508,0.019869436,0.07372897,0.054535713,0.002549176,-0.06800272,-0.13035262,2.1608547e-33,0.061321888,0.043348968,0.005822692,-0.06376498,0.05005358,-0.042369034,-0.0816556,0.06731612,0.059103727,-0.027401935,-0.094092734,-0.062943034,0.001121118,-0.026628599,-0.03324992,-0.1090327,0.028589731,0.005445478,0.060413025,-0.025199268,0.0370676,0.0705376,-0.05768919,0.054770872,0.0049998118,0.08510956,0.040595442,0.03732756,0.025149724,0.015452215,0.0031908727,-0.1587057,-0.08566727,0.012666525,0.061591644,-0.011158433,-0.08953451,-0.0031276792,0.017623158,0.05352336,0.03906305,-0.0082851285,-0.036952607,-0.0047650523,0.06423373,-0.021540789,-0.028595533,0.102014214,0.014813669,0.07361782,-0.0062214932,-0.05507341,0.106606774,-0.022653088,-0.09042083,0.015442799,-0.035621025,0.042973313,0.06334394,0.037167624,-0.0015644284,-0.008945929,-0.034021027,0.033736978,-0.0177244,-0.037346363,-0.040403064,-0.040331073,0.034806658,0.04965789,-0.010311135,-0.017803336,0.0336456,0.04438511,0.007198796,-0.018022059,-0.061485752,0.04793682,0.08354598,-0.030568924,0.027113061,0.016576318,-0.061603814,-0.082242854,-0.048411947,0.037507616,-0.017276749,-0.06269749,-0.057569984,0.04521344,0.009676566,-0.08059049,-0.009967565,-0.036520444,0.10529627,-2.463548e-33,0.06545045,-0.12443755,0.03145402,-0.03516951,-0.03116079,0.048028804,-0.058396127,0.04376125,-0.051548284,-0.023597945,0.04000919,-0.024991667,-0.018138707,-0.0330599,-0.032506093,0.015855858,0.050772443,0.042035554,-0.018083164,0.022719746,-0.048215892,0.06728843,-0.003271653,-0.01164662,-0.007778052,0.06843957,0.023973377,0.06823883,0.03403186,0.098923035,-0.002282451,-0.030452292,-0.08683701,-0.039586622,-0.04730437,0.079015866,0.0006959676,0.017896725,0.01009789,0.040010933,0.043265097,0.012520169,0.03424226,0.09591203,0.09105841,0.06851642,-0.12864208,0.0341424,0.047556538,-0.06669676,0.07557951,0.041809272,-0.0043750084,-0.004051297,-0.0002588989,-0.018323215,0.050854683,-0.07442766,0.009633792,-0.009038601,-0.02894195,-0.11197729,0.016004046,0.030838374,0.046989903,0.015638666,-0.007434556,0.088832185,0.07387151,-0.017226236,0.06438765,0.0008401453,0.043664467,0.035339106,-0.038554635,-0.052878205,-0.042591896,0.027149899,-0.010267593,-0.02163662,-0.030411616,-0.08094618,-0.0067724762,-0.09725678,-0.009795281,-0.0635776,0.06708919,0.06437916,-0.045017716,0.05238702,-0.044261515,0.0445748,-0.03778857,0.054891683,0.04320306,-3.8400724e-08,0.03230146,-0.06650287,0.0327266,-0.03519456,0.058114067,0.027253544,-0.007297176,0.016295834,0.035600167,-0.037218705,-0.013497074,0.057008505,0.00011567016,0.021762349,0.044008262,0.011501651,-0.01444367,0.017538443,-0.017911775,0.009892823,0.026338736,0.02443228,-0.09179775,0.01764463,0.02713595,-0.028908746,-0.007280631,0.033731554,0.019283213,0.003231472,0.02332395,0.09999083,0.0015932816,8.9688865e-06,-0.12738146,-0.05874026,0.05797845,-0.089322664,-0.035786293,-0.053632587,-0.009960594,0.025317183,-0.07821384,0.041319735,-0.03171107,-0.026743528,0.027512634,0.051206414,-0.052649036,-0.022953771,0.03862278,0.0266477,-0.017434837,0.009691311,-0.12378961,-0.0055608237,0.019698264,0.0027851665,-0.075191446,0.021265578,0.044923585,-0.0020203518,0.15602566,-0.026776992 +2.7.9.6,"The enzyme, characterized from a diverse collection of Gram-positive bacteria, inactivates the antibiotic rifampicin by phosphorylating it at position 21. The enzyme comprises three domains: two substrate-binding domains (ATP-grasp and rifampicin-binding domains) and a smaller phosphate-carrying L-histidine swivel domain that transits between the spatially distinct substrate-binding sites during catalysis.",384,0.99999994,-0.023501921,-0.090700075,-0.10826755,-0.06663312,0.033725016,0.0025613992,-0.067291535,0.056351863,0.061082017,-0.0487157,0.041967425,-0.04806487,0.08942838,0.11287001,-0.0066097933,-0.02575228,-0.07889697,0.042758975,0.010511494,6.347862e-05,0.09159555,0.012273509,-0.0036724436,-0.019017687,0.01698425,0.0438377,0.11318674,0.0022652943,0.022931324,-0.07615729,0.04983861,-0.0061546857,0.06601777,-0.051919866,0.03993469,0.073099926,-0.055139318,-0.06019915,0.13728206,0.04505515,0.018409787,-0.01708733,0.062002014,-0.020481046,-0.022025883,-0.01155099,0.054532297,0.07513083,0.07267765,0.004957362,-0.038639683,-0.015381921,-0.017400952,0.06825785,-0.060801312,0.07121168,-0.039525345,0.008922458,-0.03495812,-0.001561033,0.062411956,-0.0009042074,0.09106792,0.023370225,-0.01965363,-0.075815655,-0.016985314,-0.04422848,0.02228996,0.041707568,-0.061286382,-0.019928638,-0.0051212176,0.046142,0.09680782,-0.0062582633,0.009897207,0.03445192,-0.004872875,-0.06272927,0.04043739,-0.0059622484,0.06161269,0.104973786,0.0011088174,-0.082675435,0.039087553,-0.026859012,0.12246267,0.023006596,0.055255745,-0.054232303,0.016380338,-0.08304636,-0.104821675,-0.016834024,-0.039122384,0.029436333,-0.065734416,-0.02400626,0.013958216,0.019497462,-0.022292992,-0.039719366,0.003951415,0.018839834,-0.056815926,0.09642607,-0.050682604,-0.047067758,0.019931046,0.08995642,0.0486666,-0.020039422,0.009725771,0.04929059,0.05454037,-0.08677095,-0.051294032,-0.010742698,-0.04906278,-0.09726219,-0.0052257767,0.01397183,-0.049346656,0.039305124,-0.07828504,2.1082432e-33,-0.017595263,-0.012702218,-0.0435018,-0.062174913,0.023902161,-0.009036552,-0.022214489,-0.0107578505,-0.08361399,-0.036271054,0.025034958,0.030089434,0.022752065,0.06848545,0.011294605,-0.04370533,0.043672226,0.02029942,0.048340563,0.0054099485,0.005494462,0.03760459,-0.005073923,0.00037807264,0.07166195,0.093067996,0.0019270638,0.05662116,0.030687971,-0.007843495,0.016654894,-0.050871853,-0.08787975,0.03374698,0.05445191,-0.06475509,-0.035926856,-0.02815344,0.026222402,-0.033569764,-0.021151783,0.001084837,-0.008198318,-0.013418907,0.045428466,-0.024003813,-0.02199072,0.12785518,-0.022994334,0.07930877,0.08527114,-0.033588126,0.06540748,-0.041255344,-0.04603722,0.022199426,-0.03466986,0.00013983402,-0.009421954,-0.05084716,-0.0023529176,0.021519756,-0.08664656,0.027026283,0.029701604,0.030351803,-0.030599242,-0.12076665,0.074396715,0.10644115,-0.059566915,0.022840692,-0.03618504,0.0811344,-0.025615687,0.0044575436,-0.07744733,-0.014373633,0.08270576,0.058201924,-0.053568393,0.037012506,-0.019779311,0.0034134001,-0.06084345,-0.059561413,-0.027548004,-0.102379,-0.071300074,-0.02155594,0.009036982,-0.03968711,-0.04020867,0.092716694,-0.020168025,-3.43821e-33,0.10836276,-0.12088571,0.024821442,-0.0287849,-0.08577047,0.030614361,0.0010073823,0.007922367,0.05168426,-0.028962692,0.0084848,-0.043024503,-0.07700229,-0.016593175,0.047907334,-0.007778416,0.0911978,0.03435992,-0.063346125,-0.04405455,0.011750039,0.048415493,0.022519171,0.075156644,-0.038500324,0.011565012,-0.020446122,0.023889998,-0.046316635,0.052268445,-0.046731263,-0.04204059,0.005094964,-0.08313296,-0.08877468,0.03486284,-0.032028757,-0.018853476,0.03320126,-0.051654816,0.079825945,-0.0064983545,-0.048822552,0.044712305,-0.034832876,0.0861792,-0.06920793,0.08036529,0.003459857,-0.06354719,-0.020180238,-0.022097511,0.094682515,-0.016452512,-0.012407419,0.004479119,-0.019031614,-0.010713158,0.048314355,-0.05272791,-0.025766244,-0.06332578,-0.00901212,0.036101993,0.00044791307,0.03352228,-0.014303408,0.018775063,0.045357704,-0.07616806,0.047381327,0.016493378,0.04567615,0.017364798,-0.034498733,0.01631465,-0.026480343,-0.059370305,0.047570705,-0.02427019,0.030912556,-0.04917754,-0.046803106,-0.0852829,0.004979297,0.032913513,0.038626537,0.049148284,0.065169066,0.022768483,0.09081664,-0.0012692417,-0.039170522,-0.018563008,0.072767794,-4.0970303e-08,0.032161687,-0.06354514,0.041375637,-0.07930941,-0.014397721,0.054485485,-0.05802015,-0.015696779,0.011470836,0.05055289,0.014359429,0.078361124,-0.066620514,-0.0054892767,0.015945178,0.032654606,-0.030568222,0.04998805,-0.039208,-0.021856299,-0.029637406,0.02127035,-0.08957464,0.023476554,0.1311784,-0.061858017,-0.013244604,-0.05497011,-0.05998723,0.03955853,0.06974231,0.0051962305,0.01757032,0.009461016,-0.055874623,-0.014183859,-0.014845202,-0.047475107,-0.0025975492,-0.0013300279,0.038230207,0.053042136,-0.06691253,-0.0254562,-0.06767887,0.07598381,-0.0031994267,0.06538782,-0.021614874,-0.056572158,-0.013164086,-0.031220835,-0.02007306,-0.05369371,-0.12454078,-0.019224845,-0.028762178,-0.08961082,-0.01730358,-0.026872063,0.06031065,0.032090057,0.13287425,0.004170208 +3.1.1.103,"The enzyme, characterized from the bacterium Staphylococcus aureus, removes D-alanine groups from the teichoic acid produced by this organism, thus modulating the electrical charge of the bacterial surface. The activity greatly increases methicillin resistance in MRSA strains.",384,0.99999994,-0.077752955,-0.010656849,-0.061249975,0.008804448,0.023735497,0.014472271,-0.08736825,0.065083735,0.08067812,0.038739976,-0.03929651,-0.07458451,-0.033572644,0.088739224,-0.0713224,-0.0032451379,-0.013442491,0.0102871545,0.0038832608,0.017226934,0.05548317,0.06871795,0.002413253,-0.014888838,-0.018333081,0.041869376,0.01896618,0.055652294,0.020442102,-0.037475187,-0.021535816,-0.033117462,0.106217265,-0.025959278,-0.01985853,0.062231693,0.0003238165,0.041328028,0.013124647,-0.0010395779,-0.024576936,0.024411116,0.066879064,-0.008438439,-0.029880982,-0.054640606,0.015379626,0.045893036,0.06330389,-0.049968474,-0.014716444,-0.03106266,-0.044243008,0.04720572,-0.023570402,0.028424073,-0.02922763,0.0053327763,-0.026513997,-0.07527422,0.020290673,0.026345465,0.089228794,0.024652947,0.007883183,-0.06360021,-0.005962987,-0.04323201,0.074588396,-0.01563348,-0.03973748,-0.035141815,0.028651321,-0.04798784,0.053080615,0.0059783347,-0.0392655,-0.06434769,0.036365155,-0.029147027,0.004611807,-0.030610826,-0.05368661,0.10399563,0.048430964,0.029464144,0.014515861,-0.12447892,0.015064323,-0.0020832357,0.04581851,-0.025917388,-0.0017640211,-0.09293156,-0.09316175,-0.050686955,-0.017806437,-0.01944872,-0.019102935,-0.0044200434,-0.036164355,0.11811419,-0.10994418,-0.014153277,-0.06578345,-0.06529701,0.033164803,0.03154093,-0.016856216,-0.030105399,0.1288233,0.056491185,-0.01968388,0.03272606,-0.06044756,-0.002056254,0.063539386,-0.06685464,-0.07107002,0.015897386,-0.0355146,-0.064204775,0.0072473194,0.0010865349,0.052485533,0.024437135,0.013244189,1.2758699e-33,0.02661,-0.030376934,-0.020504698,-0.065540425,0.05095238,-0.06457793,-0.0671738,0.0021094172,0.07937418,-0.028582051,-0.10185576,0.054453682,0.080461085,-0.01059265,0.047699064,-0.020721575,0.04508795,-0.041909017,0.038397565,-0.006403203,0.04968025,0.055255365,0.041038178,0.047513697,0.024555242,0.017431665,0.01446796,0.07213399,0.05166911,0.0015133112,-0.07047357,-0.020025186,-0.10778867,0.070992805,0.03330457,0.12340039,-0.1230979,-0.03564667,0.07001916,0.06245718,0.007843089,0.0002162331,0.04769019,0.036749747,0.021139191,-0.050498642,-0.032029096,0.07522582,0.04279031,0.03140173,0.037417635,-0.0571902,0.062954545,0.01841245,-0.060906067,-0.0057886573,0.0023125052,-0.021572428,0.033274647,0.0981617,-0.067301676,0.016392963,-0.059828375,0.07241191,-0.049459282,-0.032353085,0.024564434,-0.055792116,-0.009897345,0.06541851,-0.034228202,0.013841107,0.006373546,0.060184345,-0.06399116,0.065457985,0.02588257,0.021792445,0.11005461,-0.057710756,-0.019913256,-0.028211862,-0.013077215,-0.038285065,-0.0893673,-0.012180716,0.020450199,-0.04539718,-0.023407847,-0.054466303,0.059413362,-0.05540576,-0.035876203,0.045647793,0.002304071,-3.083398e-33,0.025477268,-0.10978952,0.052547425,-0.063916385,-0.036858328,0.059988864,-0.054498788,0.017870858,-0.00033640684,-0.08465871,0.048400443,0.0008286513,0.010930637,0.03437135,0.04369701,0.01057187,0.019909697,0.016626095,-0.043126363,-0.05303578,-0.042136155,0.09008396,0.05335374,-0.005663556,0.048199125,0.0005329001,-0.016686128,0.043754343,0.006829709,0.011840948,0.040115584,0.0011364558,-0.0958482,-0.0019327868,-0.08716146,0.11380192,0.015324269,0.041480187,0.06982112,0.053679816,0.09829303,-0.017071556,0.052825723,0.080711365,0.025574945,0.1048769,-0.12209156,-0.02823789,-0.0030445703,-0.035426978,0.06366975,-0.022138955,0.021506988,0.0005516686,-0.000105740466,0.04357751,0.06960877,-0.050024528,-0.015114268,-0.0060226494,0.008210978,-0.078700855,-0.0244426,0.04230072,-0.06221241,-0.027056567,0.051279634,0.029368777,0.07633535,-0.056711532,0.0836873,0.032106653,0.016405491,-0.035025384,-0.08866638,-0.079638705,-0.124607876,-0.041183382,0.04759884,-0.03882578,-0.034401085,-0.011023263,0.0041362457,-0.05470452,-0.026955925,-0.040033355,0.030701786,0.030045766,-0.0004946397,0.080758244,-0.015817598,0.006211981,-0.03439091,0.030342285,0.056535415,-3.2001758e-08,0.08612625,-0.054033022,0.057381038,-0.023466045,0.013240284,0.0053105387,-0.040822282,0.02246115,0.011629359,-0.014644931,-0.034755945,0.02216304,-0.017244905,-0.0064088358,0.014339704,0.14068963,-0.04402189,-0.03835017,-0.045801535,-0.09183555,-0.04734431,-0.03642579,-0.0796659,0.014824045,0.007578433,0.0028772112,0.045708995,0.045215636,-0.11726064,-0.039577685,-0.006396677,0.024693305,-0.00381126,0.029570967,-0.107481375,-0.009001656,0.05576063,-0.0659592,-0.060597427,0.04293156,0.009616611,-0.009652057,-0.11750526,0.029135063,-0.029640824,-0.0040748497,0.011535633,0.08208453,-0.052155335,-0.0144825615,0.08542617,-0.019693203,0.01902266,0.02330057,-0.13122787,-0.025884023,-0.039567657,-0.05008533,-0.020636905,0.041915137,0.02441366,0.0026323027,0.10603303,-0.05878028 +3.2.2.31,"The enzyme serves as a mismatch repair enzyme that works to correct 7,8-dihydro-8-oxoguanine:adenine mispairs that arise in DNA when error-prone synthesis occurs past 7,8-dihydro-8-oxoguanine (GO) lesions in DNA. The enzyme excises the adenine of the mispair, producing an apurinic site sensitive to AP endonuclease activity. After removing the undamaged adenine the enzyme remains bound to the site to prevent EC 3.2.2.23 (MutM) from removing the GO lesion, which could lead to a double strand break. In vitro the enzyme is also active with adenine:guanine, adenine:cytosine, and adenine:7,8-dihydro-8-oxoadenine (AO) mispairs, removing the adenine in all cases.",384,1.0,-0.014350303,-0.0452442,0.051681787,-0.026175696,-0.03955697,-0.04891387,-0.033912946,0.024956768,0.017048081,0.015245822,0.08137497,0.08829994,-0.09320841,0.076238625,-0.058369067,0.08870275,-0.11404933,0.025130413,0.0146651,-0.07133355,0.042795286,0.09391768,0.038533963,0.04087623,-0.060966652,0.009994603,-0.0012783648,0.039688937,-0.03165803,-0.10069682,0.010908841,-0.09492837,-0.004100461,0.030307287,0.0006205399,0.08303489,-0.029489404,0.0023851723,0.008565899,0.040223833,0.049875177,0.038919836,-0.075540826,0.03667881,-0.00654483,-0.05868154,-0.01827552,-0.03358846,0.0073938407,0.075164765,0.08668291,-0.03443376,0.021384003,-0.018010862,0.079367176,0.04277553,-0.07747131,0.042440616,0.008257097,0.085268825,0.06827661,-0.005238386,-0.016607055,-0.02701764,0.070163876,-0.03588539,0.0887688,-0.14484335,-0.033396773,0.00016092144,-0.018109616,-0.08349569,0.02951277,0.023694895,-0.02599626,0.10494182,-0.05568229,-0.030564342,-0.020441754,0.023639262,0.036603127,-0.04686881,0.023682222,0.027364874,0.06959643,-0.013417567,-0.008544265,0.022976333,0.027791163,-0.014263028,0.009316681,-0.022838429,0.025215033,0.036608342,0.055626277,0.026939534,0.0085408185,-0.013451955,-0.035644535,-0.0077613695,0.03413379,0.008838117,-0.032430902,-0.06730308,-0.03357733,-0.020138908,-0.015693167,0.019736314,0.040723797,0.00080976746,-0.005561711,0.076183036,0.04970712,0.030671984,-0.01754829,0.12957351,-0.030118447,0.00524987,-0.0773348,0.06422206,-0.070404425,-0.021782987,0.03785654,0.07565473,-0.054057747,-0.06325984,-0.02503506,2.1903271e-33,0.04054007,-0.013873933,-0.017308803,0.042047646,0.010388697,0.04474659,-0.0790492,0.040395062,-0.055757836,-0.048256963,0.0034962106,-0.1049161,0.0606678,-0.025937688,-0.025422696,0.020054238,-0.0142416945,-0.0070980424,0.024513878,-0.017229678,0.010669263,-0.041813657,-0.0070503945,0.013643254,-0.010443625,0.066327386,-0.06404909,0.015574293,0.1389407,-0.01956865,-0.06000776,-0.08477807,-0.046153717,0.04739436,-0.06330978,-0.018504634,-0.041065045,-0.011922275,0.0125859175,0.110870704,-0.052111614,0.005340946,-0.009121636,-0.0028613342,0.10565868,-0.08216318,0.058253057,0.094486035,0.012373319,0.0683169,0.022467654,-0.059710547,0.022026405,-0.015292362,-0.09525631,-0.004087747,-0.015888864,-0.0427373,0.052856773,0.0151624745,0.14190833,0.05186096,0.0019055872,-0.023692604,-0.048064787,0.022756172,-0.038041152,-0.07392133,-0.0288601,0.054998305,-0.029167678,-0.05781009,0.011528866,0.03084771,-0.04386525,0.020441305,-0.014352909,0.05130361,0.046466067,0.00992224,0.019002827,-0.03268404,-0.016439393,-0.00046494565,-0.06664484,-0.022521552,-0.016936945,-0.07482467,-0.024641857,0.06492909,0.16139555,-0.030715896,-0.09519447,-0.028293587,0.08299989,-3.17593e-33,0.061275665,-0.07015232,0.033113252,-0.04628792,0.008202604,0.032591414,0.059504196,0.037261218,0.045330625,-0.07506493,0.011930964,-0.028597165,0.015644634,-0.082748845,-0.001441646,-0.0040407865,-0.01578281,0.07859326,0.010721873,0.016945153,0.08915888,0.05569648,-0.020652972,0.020689338,0.035371356,0.031090926,-0.032916002,-0.05321354,0.061915,0.029443525,-0.04621685,-0.014159313,-0.04984535,0.056926858,0.043027144,0.03250119,-0.030266233,0.0051538083,-0.03914114,-0.051349115,-0.024166195,0.05221454,-0.013553197,0.08232924,0.00380289,0.14997226,-0.057479028,0.026648687,0.0054029967,-0.054019485,0.022805719,0.022492483,-0.03624941,0.01727495,0.03662566,0.051834147,-0.031977516,-0.05007062,-0.099634685,0.044378445,-0.045237627,-0.052356604,0.0018387525,-0.030386062,0.0023983256,0.017962448,-0.037976816,0.041517597,0.007721068,-0.027260404,0.02207929,-0.03079533,-0.044995654,-0.032163147,-0.02718982,0.02409563,-0.05579086,-0.060673922,0.016561665,-0.054972887,-0.047882844,0.022736551,-0.0184861,-0.014393807,0.10021134,0.0045605344,0.039071888,0.08504445,-0.02329582,0.0043314397,0.025607536,-0.01607603,-0.012269802,-0.00036871608,-0.013806018,-4.5868642e-08,-0.020532753,-0.09353787,0.020253807,-0.08500771,0.04805747,-0.033508383,0.030650811,0.11878279,0.06039526,-0.08178038,-0.066617444,0.027087241,-0.020716222,0.055851944,0.023793314,-0.0025354323,-0.033287603,0.07903722,0.0116078,-0.03626361,-0.13527708,-0.0314925,-0.08858853,0.00966852,-0.0035864091,0.034748904,0.02668871,0.11546824,-0.06911624,-0.08951708,0.057412427,-0.05567163,0.03709288,-0.011266107,-0.08145379,0.036379803,0.02587959,0.046019312,-0.06587839,0.017202962,0.018205052,-0.023011455,0.009469568,0.030508367,0.005420355,-0.032335266,0.024700446,0.010806532,0.011322343,-0.04668898,0.10435232,0.01645695,-0.028346771,-0.038859602,-0.071577676,-0.06667003,0.017635608,-0.11299826,-0.043953873,-0.0426602,0.009071257,-0.03145737,0.13474205,-0.047116656 +3.13.1.7,"The enzyme, characterized from the bacterium Thiobacillus thioparus, catalyses a step in the degradation pathway of thiocyanate. This activity is also catalysed by the archaeal EC 3.13.1.5, carbon disulfide lyase.",384,1.0,-0.063954905,0.031241845,-0.07698027,-0.005292187,0.06934131,-0.015003682,-0.07046598,0.035755407,0.04223402,0.029706938,-0.047886495,-0.093794815,-0.031889856,-0.026295444,0.007419966,0.03522934,-0.073098265,0.02302499,-0.013326194,-0.029704716,0.06641279,0.06856225,-0.06799413,0.013166465,0.043916866,0.039398007,0.07783672,-0.06272932,-0.063941754,-0.06466408,-0.012125486,-0.07513964,0.06979426,-0.008989804,0.014139871,0.12700093,-0.08479315,-0.09391494,0.10340394,-0.051670678,0.00090635684,0.002349259,-0.0077341497,-0.056079317,-0.06458247,0.009721372,0.053094618,0.05457932,0.021757152,-0.061268732,-0.033957254,-0.027625257,-0.028871289,0.07950164,-0.053217225,0.0031981352,-0.017712412,-0.0046508065,0.009526274,0.024148835,0.0772411,0.034618307,0.007104935,0.03328353,0.009647191,-0.059198715,-0.00089444575,-0.029689167,0.0026535327,-0.010169822,-0.06741642,-0.007917833,-0.00994092,0.03086785,0.036735926,0.029551378,0.0070219454,-0.018793928,0.024325348,-0.056807805,0.037638396,0.03757608,0.051993802,0.08640776,0.008522316,0.027868792,-0.0028502443,-0.025569301,0.09098765,-0.0093899155,0.07082432,0.043713626,0.027171081,-0.04500412,-0.041514486,0.014582135,0.015608376,0.035193786,0.0624325,0.0031296888,0.021427209,0.064656235,-0.08635688,-0.11507966,-0.06406692,0.038769297,0.053951956,0.10831646,0.048143078,-0.008388164,0.009799093,-0.042746246,0.024648108,0.015979711,-0.044262607,0.07881018,0.068559706,-0.046873674,-0.09003468,0.0019787448,-0.008229058,-0.030109322,0.07289237,0.021400897,-0.077685535,-0.0019083779,-0.10965263,2.7582569e-33,0.060302313,0.009221113,0.009893137,-0.08656254,0.042457193,-0.03862777,-0.073302366,0.014706099,-0.037247147,-0.040024225,-0.09311441,-0.1072865,-0.029385446,-0.032479618,0.01579782,-0.024331959,-0.049091354,0.03996375,0.028395666,0.0034807639,-0.011949438,-0.00033240695,-0.03493793,0.0011109638,0.048137054,0.102648765,0.09463662,0.049359478,-0.0131245805,0.003524258,0.006494605,-0.108209,-0.10196606,-0.008885904,0.02793678,-0.014865834,-0.07150135,0.04070392,-0.028515257,0.0012062227,-0.011818855,0.04581227,-0.015564684,-0.09024311,0.016403303,-0.023283496,0.045355517,0.12302905,0.008099695,-0.011301834,-0.0005729526,-0.048093412,0.10444447,-0.05923804,-0.045272645,0.0117877945,0.0401049,0.0047205645,0.04183645,0.05455867,0.0841132,0.04694954,-0.032983698,0.05944171,-0.07250215,0.05004775,-0.05026516,0.014705557,0.025987696,0.057541866,-0.056723483,0.018006103,0.071274534,-0.023011882,0.014856003,-0.048375566,-0.07360178,-0.045500897,0.0143977,0.002350886,-0.001440121,-0.08690592,0.025554389,-0.02340393,-0.009721618,0.020641992,-0.024126269,-0.054135866,-0.021853209,0.07899213,0.0072290404,-0.07682398,-0.05170542,0.028465793,0.006203087,-2.303276e-33,0.050220795,-0.03358508,0.033203,-0.0656743,-0.04994211,-0.018609798,-0.069764346,-0.0053261113,-0.010404201,-0.02588213,0.056851257,-0.023353547,0.054775376,-0.050248872,0.032446068,0.00738092,0.041696243,-7.0823394e-06,-0.030108843,-0.057416867,0.032764416,0.009000938,-0.02567402,-0.086131535,0.04300651,0.014052476,0.02363647,0.10628706,0.09906154,0.05640513,-0.01093968,0.019878283,-0.016486613,-0.032604232,-0.09556554,0.049058013,-0.020583224,-0.035678804,0.0784793,0.017311169,0.030962259,-0.01435286,0.017033296,0.056624357,-0.015017638,0.07718437,-0.04685388,0.012199325,0.038911566,-0.07782207,0.06953667,-0.010094423,0.026772771,0.03628277,-0.0062282295,0.08683177,-0.0046220683,0.058463834,-0.04755211,-0.051574115,-0.06383092,-0.088018104,0.0597243,0.0019262662,0.040686857,0.010396522,-0.08828449,0.096852206,0.025457727,0.020928174,0.13563561,-0.023180913,-0.053476162,0.019826692,-0.018748168,-0.0002723143,-0.032677457,-0.045960166,-0.009650278,0.0057463446,0.031089604,-0.037566923,-0.018746428,-0.085814364,0.028897103,-0.031083379,0.041727196,0.095838144,-0.09001385,0.108477734,-0.04043281,0.005882824,0.015600914,0.08265797,0.044305846,-3.1654753e-08,-0.041916788,-0.07918367,-0.0051155975,-0.0036434396,-0.0002246092,0.07267688,0.047767546,0.09516672,0.06618352,-0.04712507,-0.039472125,0.04574415,0.038334183,0.001986273,0.04282869,0.031211033,-0.00029169273,-0.0019764255,-0.013424185,-0.033685043,0.0012160636,-0.059124924,-0.036783688,0.0010283662,0.0073486343,-0.04325609,0.0030980867,-0.034286115,-0.05514231,-0.002968015,-0.056252845,0.061859507,0.0049780817,-0.040194362,-0.008870489,0.05222743,-0.09534414,-0.07358428,-0.024438161,0.014393433,0.016423732,0.09479421,-0.1265959,0.034738164,-0.00880185,0.019770736,0.029091893,0.097364835,-0.05422225,-0.049575083,0.028696375,-0.045371085,0.009940263,-0.03534622,-0.036258727,0.025777742,0.014424119,0.011428293,-0.035560075,0.04082156,0.06827191,0.03145816,0.19803911,-0.064155035 +5.3.3.21,"The enzyme participates in an alternative degradation route of fatty acids with cis-double bonds on odd-number carbons such as oleate and linoleate. The main physiological substrate is (3E,5Z)-tetradeca-3,5-dienoyl-CoA, but other (3E,5Z)-dienoyl-CoAs with varying carbon chain lengths are also substrates.",384,0.99999994,-0.037951123,-0.06481892,-0.034265663,0.012872343,0.12356526,0.0042866357,-0.09431509,0.026958851,0.01574589,-0.049492758,-0.023133954,-0.033696763,-0.070215896,0.016892528,0.04114395,-0.044894636,-0.04000098,-0.00036700195,-0.0043368773,-0.0367439,0.08000595,0.0037708879,-0.03415885,-0.0056505944,-0.0012848383,-0.039849784,0.046005443,-0.059406687,0.027342573,-0.061209053,0.042515144,-0.05157239,0.01118148,-0.037208516,-0.029214004,0.045496743,-0.010665589,-0.070920415,-0.012576286,0.024651563,0.05688664,-0.05489864,-0.029387334,-0.06219795,0.020061417,-0.07733809,-0.074072964,-0.0076693245,0.012511449,-0.0110704955,-0.03019914,-0.11461777,-0.05307376,0.011636627,0.0031362157,-0.011159526,0.0021973536,0.013076211,-0.11733923,0.06457265,0.098859705,0.013202297,-0.0021367813,0.018774834,0.020089187,-0.01879429,0.030162135,-0.079879954,0.004134334,-0.016290521,-0.1344563,-0.07133477,-0.047943104,0.0051022684,0.020313608,0.058120687,-0.03514464,-0.07241795,0.018361403,-0.03217524,-0.002982844,0.021548452,-0.004849185,0.10988074,0.030914038,-0.0028657685,-0.017494928,0.0014919635,0.0132672675,0.056921586,0.05101353,0.051069017,-0.028789992,0.052852474,-0.08090339,0.037080158,0.0028715546,0.027686795,0.009632732,-0.040828753,-0.006496014,0.03457238,-0.028864408,-0.07120673,-0.10587778,0.048333675,-0.0249133,0.03923006,0.006978012,0.032781817,0.0063855494,-0.0061072754,0.006077951,0.040596772,-0.022081658,0.032554287,0.005101783,-0.098338,0.022581464,0.017235678,-0.06995078,-0.011028473,0.06060849,0.01646057,-0.0025863352,0.03254647,0.0073656994,4.6487036e-34,0.010089943,-0.044572014,-0.019978845,0.009418144,0.030134017,-0.0048101484,-0.0696201,0.025649983,-0.050416045,0.014153418,0.011925174,-0.03440082,0.032587957,0.03278485,0.019417414,-0.024150275,0.03284303,0.07339763,0.07863422,0.009855658,-0.027720999,0.04389793,-0.0012219754,-0.0063167117,0.08979481,0.09677675,-0.060791936,0.016740853,0.0077211577,-0.0099131055,-0.015865255,-0.06773872,-0.08321673,0.004474473,0.118840836,0.018237475,-0.014255096,0.072010905,-0.093424276,0.087816246,0.10697906,-0.00093865796,0.049710624,-0.021304253,0.011351733,0.005565925,-0.012280075,0.088968374,0.065544695,-0.044541147,0.035942744,-0.03840055,0.04745745,-0.0010890324,-0.04824327,0.058361173,-0.04515608,-0.0031081343,-0.010368584,-0.04878148,-0.030614097,0.09755478,-0.061939973,0.05889965,0.008329785,0.037520014,-0.108199865,-0.06714955,-0.010858219,0.07862686,-0.00981075,0.008010849,0.0638468,-0.00064540777,0.036299396,-0.03789153,-0.09877933,0.033519935,0.027058065,0.036324818,0.027090782,-0.050946817,0.0058411667,-0.07659076,-0.108257316,0.026378911,0.0082356,-0.0308264,0.062238228,0.0492248,0.02082489,-0.073438495,-0.0017178403,0.0017117425,-0.022563515,-3.085379e-33,0.10358765,-0.122199856,0.047915906,-0.08019609,-0.026415974,0.03529839,-0.01644372,-0.026574116,0.052992597,-0.01981883,0.11400884,-0.012203497,0.012242027,-0.018679587,0.024753228,0.02417906,-0.058111772,0.03937657,0.011536189,-0.065802984,0.03034148,0.01929725,-0.01676345,0.05738269,0.06372394,0.06128183,-0.025264028,0.07471046,0.09007852,-0.001902729,0.010398669,-0.025885167,0.028628943,-0.039282847,0.00076985237,0.059173666,-0.054854218,0.049318,0.016444013,0.040532712,-0.015590865,0.04629892,0.05080456,0.0056279623,0.011143668,0.031601287,-0.11606149,-0.05151349,-0.02664511,-0.08224389,0.062126663,-0.04680734,-0.05402409,0.035616387,0.033076987,0.106763914,-0.007611153,0.044751234,-0.0030316894,-0.091184065,-0.03658219,-0.030546712,-0.0022045975,-0.03871419,0.04988622,0.047992077,-0.055696625,-0.040245257,-0.008695283,0.009961796,0.03659337,0.057224795,-0.017794147,0.009829882,-0.079821244,-0.039758738,-0.07521194,0.006191819,-0.023379853,0.016217258,-0.0051329676,-0.036539417,-0.025010446,-0.085261695,-0.04423165,-0.052860472,-0.009193178,0.10218468,0.06609342,0.014377224,-0.040894754,0.0013862837,-0.07981404,0.024374273,0.036372796,-4.1076984e-08,0.039042123,-0.099183716,-0.017972864,-0.0045090187,-0.07520861,-0.0411808,0.049816422,-0.021307297,0.11090902,-0.013776719,-0.01914092,0.07656361,0.022257492,0.053185668,0.05554946,-0.024912266,-0.0665747,-0.02322156,0.0050984975,-0.0560327,-0.108567476,-0.059857484,-0.013761079,-0.015471362,0.030065604,-0.054040186,0.04949324,0.062273204,0.0041506905,0.024299989,-0.04171763,0.041753612,0.0435037,0.06071018,0.033216108,0.018625189,0.010723027,-0.057982218,-0.08327534,0.15883856,0.02740911,-0.012092651,-0.10486694,-0.018294068,0.05015516,-0.035160374,0.02709331,0.0833435,-0.0063977283,-0.012646644,-0.04462652,0.034389436,-0.11428645,0.0431293,-0.017391829,-0.07677555,-0.029830772,-0.014239441,-0.04476814,-0.0028089776,0.046476632,0.007570233,0.22986376,-0.0334346 +6.3.2.52,"Two jasmonoyl-L-amino acid synthetases have been described from Nicotiana attenuata [3] and one from Arabidopsis thaliana [1]. The N. attenuata enzymes generate jasmonoyl-L-isoleucine, jasmonoyl-L-leucine, and jasmonoyl-L-valine. The enzyme from A. thaliana could catalyse the addition of many different amino acids to jasmonate in vitro [1,4,5]. While the abundant form of jasmonate in plants is (-)-jasmonate, the active form of jasmonoyl-L-isoleucine is (+)-7-iso-jasmonoyl-L-isoleucine.",384,0.99999994,-0.07233885,-0.07577768,-0.1050708,0.013764772,0.025229473,0.09211626,-0.060100757,0.00636714,0.070467435,-0.0026057195,0.067953646,-0.031097766,0.017571144,-0.07619423,0.015354049,0.048520375,-0.00694504,0.07070006,-0.0532427,-0.06899272,0.020286905,0.01386958,-0.046499476,-0.039239347,0.13737676,-0.051094588,-0.026207853,-0.11270159,-0.06886733,-0.04304253,-0.06817733,-0.04361191,0.083381176,-0.06083941,0.046508677,-0.020373927,-0.05664733,-0.045146704,0.08427298,-0.019507911,-0.026691899,0.015027144,0.0012372071,-0.07367773,-0.08013112,-0.026981229,-0.002858031,-0.043183863,0.028741319,-0.029071804,-0.076343164,-0.021721257,-0.05420663,-0.036497355,-0.060932614,-0.023803568,-0.04849926,0.024022441,0.008132748,0.0989317,0.051942993,0.016733564,0.023411943,-0.080343574,0.0067850137,-0.04541219,-0.00034716493,-0.022498956,0.086112045,-0.0647184,-0.02515847,-0.050041158,0.0016396381,0.03490847,-0.027980216,0.027342428,-0.026850114,0.1066925,0.024618857,-0.029256413,0.018996319,0.0035394465,-0.024364183,0.032946225,-0.016620241,0.041601006,-0.053360548,0.11124971,0.0897001,0.075821914,0.07085615,0.054198686,0.01716086,-0.015470182,-0.030728333,0.068901256,0.059870653,0.013032388,-0.031092722,-0.000578031,0.06626426,0.0132111665,0.010299879,-0.03820592,-0.025814421,0.020170502,-0.06667385,-0.06853023,-0.007865885,-0.05563068,0.034646563,-0.06004361,-0.027487824,-0.021373533,-0.034052424,0.041786395,0.06463545,0.0034245248,-0.049605306,-0.024169507,0.040869523,0.002454281,0.092425294,0.02131725,-0.030839544,0.01936446,-0.11352941,3.639405e-33,0.06634191,0.05719312,0.011398368,0.055072986,-0.00353357,-0.050940104,-0.049245764,0.09245719,-0.016387127,-0.042225547,-0.11279178,-0.06578843,0.002498378,-0.0627847,-0.0520167,0.015054393,-0.018643266,-0.09665087,0.017908987,0.038095746,-0.04478129,-0.001124446,0.011499631,0.05979361,-0.03896183,0.013458294,0.022142924,-0.07180046,-0.033188205,-0.002885821,-0.039571904,-0.06698994,-0.044134844,0.00068763545,0.08110612,0.021197015,-0.0122087905,0.0057280064,-0.06429442,0.03275348,-0.011984151,0.058507215,-0.0059933816,-0.012366975,0.07340383,0.046155386,-0.03597781,0.022227418,0.07439655,0.06689967,-0.03218784,-0.0060329526,0.12657516,-0.027126383,-0.032445516,0.07286863,0.041879527,0.055810858,0.01496058,0.08358202,-0.05195302,0.008896658,-0.0012480563,0.02393838,-0.024036752,0.06458099,-0.112287186,-0.07729243,0.024184143,0.06120357,-0.009810802,-0.08604733,0.04935729,0.055819776,0.056959305,-0.09155896,-0.064131975,0.047875725,-0.009171706,-0.030245181,0.05555712,0.0045226924,0.012600476,0.018715367,0.0037336578,-0.01723983,0.025462646,0.0003986886,0.016098626,0.06931895,0.034183744,0.0077325967,0.013744643,-0.013306277,0.057380795,-2.8832052e-33,0.053535387,-0.027019326,-0.065824136,-0.031325772,-0.054964665,0.03482238,-0.04301334,-0.05482234,-0.04569587,0.022286842,0.055166885,0.016980514,0.015554133,-0.034956016,0.006049993,-0.045247782,0.094610125,0.054958455,-0.018024072,0.0015697791,-0.03566811,0.018933024,0.020711482,-0.015391102,0.039527822,-0.018536365,0.05142968,0.07093305,0.008507775,0.055602748,0.027154494,-0.014090416,0.012466602,-0.0608878,-0.014451018,-0.0050540585,-0.02683173,0.037807535,0.0038398302,0.01279904,-0.064067736,0.005700945,0.02977798,0.02553949,0.011057719,-0.030112363,-0.05940513,-0.009159047,-0.07100845,-0.040571615,0.086333565,-0.054770645,-0.02924934,-0.011747048,-0.008712612,0.02128694,0.01619947,0.105394155,0.030493842,0.0039837305,-0.034228366,-0.08319908,0.015974766,-0.040209897,0.07713875,0.057694845,0.03635343,0.08385874,-0.01892306,-0.0019420857,0.06159501,0.0022640128,0.07421696,0.05555331,0.014755395,-0.07793343,-0.011674724,-0.033205785,-0.04134632,-0.064651944,-0.016231677,0.008920274,-0.010868496,-0.05369636,-0.00027776347,-0.021807466,0.06235198,0.106422395,0.053583886,0.048160337,0.022264285,0.0029330521,-0.065826364,0.028590066,0.0658825,-3.843723e-08,-0.010108982,-0.052020717,-0.039446056,0.0044007506,0.018461643,0.0032482296,-0.011144239,0.0054710214,0.03308224,-0.028383736,0.0065642293,0.08381437,0.015204836,0.08536347,-0.02609908,0.015561793,-0.016595995,0.14480458,-0.022752104,0.13800776,-0.033154562,0.09851531,-0.13320835,-0.07400848,0.056345887,-0.08924977,-0.030838707,0.023603946,0.12810495,-0.015348953,0.024461303,-0.03160206,0.06090507,-0.09393137,-0.13730243,-0.07096985,-0.0005394035,-0.09183023,-0.008596026,-0.036943264,-0.012722945,0.009163399,-0.048882376,0.0249369,0.0059519764,-0.040016137,-0.01650122,0.045941412,-0.04826849,0.0625224,0.016666837,-0.011765802,0.049405646,-0.1105596,-0.06494115,-0.055717222,0.06427449,0.0003276817,0.018267862,-0.023950337,-0.048720606,0.0021095418,0.10479999,0.02106891 +1.7.1.17,"Requires FMN. The enzyme catalyses the reductive cleavage of an azo bond in aromatic azo compounds to form the corresponding amines. Does not accept NADPH. cf. EC 1.7.1.6, azobenzene reductase.",384,0.99999994,-0.039926793,-7.214637e-05,-0.11587222,0.018832395,0.030026115,0.009178823,0.009631119,0.008970297,0.029441915,0.009285566,0.010703312,0.013895126,-0.063970566,0.14280123,-0.030084342,0.031374753,-0.108715475,-0.020339118,-0.027551277,0.0046749064,0.014845798,0.034737557,0.022173766,-0.036646064,-0.01785587,-0.041524112,0.023667982,0.0111829955,0.0017417065,-0.021976184,0.00067288347,-0.009626592,0.046380784,-0.05208091,0.030321486,0.063722916,-0.00033069547,-0.06314576,-0.0509262,0.022390988,0.019503199,0.008306684,-0.009268295,-0.09828147,-0.01620701,-0.025878195,0.041312203,0.06756991,0.025177054,0.0100074755,-0.110549636,-0.0023226307,-0.04210211,0.07088838,0.048762716,0.05480668,-0.059810188,-0.034698136,-0.13267614,0.014247644,-0.0034436362,0.0020958113,-0.05148028,-0.016997451,0.076791726,-0.014605536,0.0031654234,-0.07401161,-0.046156436,0.018750288,-0.04196204,-0.08214906,-0.046712533,-0.037769824,0.01019058,0.05481496,-0.0010605195,0.0018883685,0.04079476,-0.037029747,-0.014009279,-0.008025754,0.04139994,0.041110735,0.09140376,0.053656463,-0.028428735,-0.00023597408,0.037805762,0.09129929,0.016694698,0.021637019,-0.0074849925,-0.05830958,0.0016757873,0.008444833,0.030255482,0.04949074,0.007387171,0.044070948,0.054852746,0.016253151,-0.08631922,-0.035229605,-0.12105291,0.025218172,0.02669327,0.059915055,-0.0176887,0.0078096553,-0.0023622005,0.0311235,0.08163964,-0.07542198,-0.0661235,0.06383408,-0.025717136,-0.08290383,-0.07324534,0.045001965,-0.037652284,0.018135244,-0.020665579,0.118293196,0.023283023,-0.01183895,-0.14392233,2.3322331e-33,0.013542375,0.12934092,0.004539049,-0.025499856,-0.049718726,0.038163625,-0.05374179,0.037595972,-0.012420116,-0.085403696,-0.056841407,-0.049351837,0.05095497,-0.09333191,0.017718438,-0.0031631587,0.01419902,-0.009287617,0.0011112078,0.03165543,0.08783666,-0.047827058,-0.03584025,-0.018059684,-0.03190073,0.0809167,-0.018340828,0.000976136,-0.017965445,-0.0016146733,0.0029339015,-0.07693543,-0.05719066,-0.008287877,0.027892899,-0.008553348,-0.07930965,-0.018015467,-0.026693359,0.06967736,0.024741277,0.024427276,-0.053971246,0.060695805,0.0384062,-0.03922722,-0.00530161,0.10596198,0.07014452,0.038701285,-0.005362748,-0.010714391,0.04795535,-0.025240911,-0.02229024,0.028539483,-0.052323658,0.011277014,0.002318833,0.041769445,0.013965662,-0.05191827,-0.06782561,0.071704336,-0.036204327,0.017146705,-0.0341574,-0.0133633185,0.06931509,0.07907094,-0.009739265,0.01989975,0.06198255,0.068096146,0.04848104,-0.06020547,0.011989511,-0.046015844,0.10096781,0.019417852,-0.0005214037,-0.023582796,-0.035255607,0.008760776,-0.089224406,-0.03936696,0.040003967,-0.0363858,-0.022922799,0.05670485,0.08564761,-0.10852981,-0.011450055,-0.040996622,0.05932757,-3.6009635e-33,0.08266706,-0.054075815,-0.02871651,-0.123156734,-0.023374008,0.039477475,0.022454856,-0.13055164,0.009636055,-0.054467585,0.034673113,-0.031714767,0.025932,-0.04336869,-0.031297106,-0.030916315,0.03828342,-0.027303718,0.12000354,0.0036032847,-0.05656629,0.074782185,-0.012886013,0.018106673,0.0017517623,0.00048761643,-0.021739287,0.101162426,0.08086799,0.07116162,-0.06587933,-0.017842496,-0.09118591,-0.057943746,0.0332605,0.11010988,-0.030786688,0.0021255848,-0.030633967,0.010586342,0.06401996,-0.025929995,-0.01991566,0.054694314,-0.00782669,0.06457927,-0.10225042,0.027993536,0.009093152,-0.0804145,0.06789863,0.018812096,-0.043784186,-0.02419771,0.020585803,0.039087225,0.014859766,0.022938991,0.006663985,0.059722498,-0.04126823,-0.046906807,0.011738131,-0.038010325,-0.00023085022,-0.029549737,0.06172637,0.10910518,0.04489165,-0.019510131,0.07658036,0.035493508,0.10190362,0.06738932,-0.067949384,-0.0019847383,-0.030730503,0.028340189,-0.0047635464,-0.09015639,0.027812717,-0.0076528247,-0.03851067,-0.053557515,0.030237658,0.02067821,0.07791156,-0.004027426,-0.067070715,-0.029437728,0.051803317,-0.007391539,0.029893601,0.053755138,-0.038448058,-3.60722e-08,0.024534672,-0.08193107,0.046737522,-0.09106467,0.054548785,0.058030706,0.06976979,-0.057317186,-0.0019127529,-0.008902943,0.004813161,0.028964344,0.06072588,0.0491428,0.044269156,-0.04726254,-0.05268668,0.062607996,-0.06570819,-0.040422972,-0.11610873,0.033905122,-0.18232773,-0.037331138,-0.003768845,-0.037871387,-0.0061112307,0.008150896,0.029317265,-0.031553674,0.055623315,0.029462792,0.09127766,0.0035127804,-0.107631944,-0.0023348506,0.017020931,-0.032233328,-0.08502544,-0.053296994,0.005020082,0.019297533,-0.010922418,-0.013151344,-0.0018605632,-0.0067489333,-0.012926534,-0.039594274,0.0058130072,0.04223662,0.05910333,0.01869014,0.0018831362,-0.03353822,-0.043438736,-0.056913026,0.05582325,-0.02736552,0.014918149,-0.023119446,0.061340142,0.03565938,0.1205521,-0.023277946 +1.13.11.85,"The enzyme, studied mainly from the bacterium Xanthomonas sp. 35Y, catalyses the cleavage of the double bonds in natural and synthetic rubber (cis-1,4-polyisoprene polymers), generating ends that contain ketone and aldehyde groups. The enzyme from Xanthomonas sp. 35Y contains two c-type cytochromes. It attacks the substrate from its end, producing a single product of 15 carbons.",384,1.0,-0.01914757,0.00018900001,-0.01159741,-0.026889637,0.044319183,0.016501013,-0.035981677,0.05424392,0.016222613,0.021401279,0.07682921,-0.06955254,0.028423466,0.037098944,0.008880147,0.061998814,-0.08616348,0.0006840039,0.04237249,0.04547108,0.061193626,0.0006865458,0.03429505,-0.023021366,-0.0060557006,0.039431464,0.050567318,-0.09076692,-0.0017220107,-0.078366905,-0.006951764,-0.027582277,0.013156281,-0.03693583,0.12086217,0.0415555,-0.03584429,-0.019601747,0.06949958,0.0077958643,0.027443176,-0.04120348,-0.00653209,-0.044873223,-0.039212864,-0.05500235,-0.022044253,0.060909685,-0.008577687,-0.0073847137,0.021148074,-0.06205373,-0.0005188029,-0.02230805,0.05204584,-0.06804122,-0.06725767,-0.027079012,-0.003248767,0.008252413,0.15950035,0.07024694,-0.021670282,0.016483858,-0.033076417,-0.0913894,0.037240695,-0.034261808,0.015828028,0.008823714,-0.09974977,-0.04995845,-0.014433137,0.023675183,0.053253066,-0.013519324,-0.0065598413,-0.048648708,0.0017334258,-0.007833588,-0.016193869,0.025120795,0.06697228,0.07337107,0.043749146,0.01046679,0.06497545,0.06768571,-0.0066793715,0.056038816,-0.005010586,0.027726507,-0.016909478,-0.048910603,-0.077804394,0.031165069,0.06450805,0.06718947,0.07948033,-0.0061104097,0.03301165,-0.01294164,-0.0039735464,-0.056287665,-0.06732216,-0.024049204,-0.045730714,0.049527008,0.05171279,0.012103998,-0.04078638,-0.06360611,-0.025346838,-0.019758016,-0.046704993,0.093362495,0.07119047,0.015809827,-0.046885297,0.013745491,0.013806753,-0.034036633,0.019215785,0.063596904,-0.05794475,-0.021905603,-0.12048674,4.8195624e-35,-0.007172202,0.07618484,0.003574787,-0.060959198,0.0048596137,-0.048578486,-0.04517584,0.06612122,-0.089092486,-0.007256653,-0.08740583,-0.065736346,0.02729321,-0.00080808136,-0.008668449,0.014964024,-0.039178338,-0.008154061,0.0376873,0.0063524474,-0.025020065,-0.01405748,-0.0067065703,0.037622377,0.012293855,0.023706522,-0.0048873103,-0.01804139,0.037546515,-0.027690193,-0.02026211,-0.050157204,-0.07490946,0.10645897,0.018554492,0.06303424,-8.437692e-05,-0.051519908,-0.005617885,0.06556204,0.008961938,-0.014944937,0.06914906,-0.08796261,0.013810862,-0.016995715,-0.11401254,0.03889099,0.0681134,0.030922445,0.06871557,0.0076083154,-0.017992025,0.020395178,-0.08774005,0.06656739,-0.06123971,-0.01079474,-0.061034847,-0.008819137,-0.01715783,0.006807277,0.007219446,-0.0066979774,-0.0050332234,0.011284177,0.00067376374,0.013962545,-0.0020767252,0.06393726,-0.13194807,-0.025371969,0.08674908,-0.044760425,0.045894995,0.018806122,-0.10027992,0.010375741,0.07112555,0.05479347,0.03367811,-0.02727498,0.038278494,-0.124467365,-0.085696116,-0.06315924,-0.038714968,-0.022278074,0.06630113,0.102303945,-0.02793111,-0.14754087,-0.08575487,0.054395523,-0.063004814,-2.447304e-33,0.062031288,-0.04640886,0.08860501,-0.03352091,-0.045591082,0.03323138,-0.024976183,-0.031394966,-0.02781825,-0.016880728,0.12487105,0.016792221,0.0732388,0.056702517,0.0044645173,0.0366803,0.046433117,0.05652294,0.0043749698,-0.04089239,-0.032857083,0.010737901,-0.043909486,-0.012075527,0.0023382078,0.067491435,0.02411988,0.013841871,0.12150418,0.039809406,0.00018351237,-0.03825792,-0.003257444,-0.020706382,0.009583672,0.02999576,-0.051210757,0.030612526,0.05971115,0.0049765697,0.03019768,-0.0038053943,0.017349249,0.06476143,0.033712443,0.042047024,-0.00994025,-0.04255631,0.029470453,-0.054343227,0.081211105,0.05703292,-0.028480964,-0.016298538,-0.05319309,0.064023934,-0.026730457,0.04522005,0.00064560975,0.0082380045,-0.060772594,-0.034779042,0.01623137,-0.040835958,0.035451677,-0.0068929717,-0.037217017,0.0018590324,-0.023778668,-0.06616029,0.08913786,0.03257897,-0.037059065,0.0537247,-0.055429306,-0.021118728,-0.015544353,-0.14838016,-0.05274251,-0.03714795,0.055819307,-0.0002895843,0.017359521,-0.059340652,0.0005879158,-0.021825204,0.04290347,0.13156284,0.010210616,-0.023184966,0.014814655,0.067123204,-0.020043828,0.0688064,0.10206882,-3.9618307e-08,-0.03432155,-0.047230136,0.014012121,-0.04960407,-0.02988251,0.060781654,0.022176683,-0.0543582,0.049120087,-0.08714887,-0.034102,0.048525523,-0.023316126,0.050024927,0.029283162,-0.050200872,-0.02947054,-0.006191835,-0.019739421,-0.076137386,-0.09104923,-0.023001703,-0.059464432,-0.03710201,-0.052421328,-0.07334131,0.034267124,0.05765207,-0.0048023807,-0.021951793,-0.08421345,0.08723484,-0.039648,0.022237705,-0.040333252,0.027441332,0.0014623738,-0.08910413,0.0006756611,0.01182585,0.07252552,-0.04265144,-0.103477985,0.015702901,0.013851692,-0.0035567668,0.016478937,0.017722294,-0.026472867,0.06418992,0.028600987,0.03220132,-0.0035287528,-0.08546178,-0.056882214,0.05127325,-0.034750402,0.0006415032,-0.046159286,-0.06906227,-0.036947582,-0.07185198,0.22773631,-0.025646685 +1.14.14.70,"A cytochrome P-450 (heme-thiolate) protein isolated from Oryza sativa (rice). Participates in the pathway for the biosynthesis of oryzalexins, a group of related phytoalexins produced by rice. Can also use 9beta-pimara-7,15-diene as substrate (cf. EC 1.14.14.68, syn-pimaradiene 3-monooxygenase).",384,1.0,-0.10834563,0.0081936335,-0.075520195,0.012289137,0.064911164,0.11732017,-0.06300064,0.022440752,0.012971826,-0.04311256,0.09825523,-0.0050428244,0.006583258,0.021474399,-0.03479572,0.027697444,-0.03789109,0.048912212,-0.06928148,-0.09501696,0.018138044,0.06458675,0.019480433,0.017934127,0.012691331,-0.059127003,0.043087464,0.056214195,-0.0052958145,-0.028627507,-0.076264784,-0.03953336,-0.018165205,-0.019535162,-0.013704446,0.08051223,-0.010517034,-0.1046678,0.058436617,-0.07259182,0.062774435,-0.04633203,-0.08234153,0.02285382,-0.037378624,-0.073361404,-0.022707427,-0.049321067,0.05192266,-0.07238923,-0.051344577,-0.00097386976,-0.019850716,0.020354338,-0.004034875,-0.06271114,0.022187727,0.0021344896,-0.08620073,0.030934518,-0.04640722,0.04146069,-0.025572095,0.028045617,-0.07253714,0.004572943,-0.07351515,0.010028345,0.0070912857,-0.07468863,-0.000371113,-0.102175854,0.0053397943,0.055099204,-0.045974255,0.047833502,0.0074658436,0.033771593,-0.03509295,-0.0532903,0.018099392,0.023551563,0.06354877,0.14709522,0.010602295,-0.023986854,-0.066952586,0.11399498,0.0015491449,-0.036001448,0.05392537,0.06306822,-0.016604766,0.018793086,-0.028405135,0.059974615,0.018658062,-0.047027152,-0.014649848,0.0044729123,0.038480073,0.0559617,-0.05976449,-0.06846285,-0.005300688,0.03575801,-0.014588129,0.009681258,0.007193063,-0.049086127,0.007925624,-0.056044035,0.0045901686,-0.005115161,-0.07112631,0.03659806,-0.007575981,-0.017039035,-0.024941834,-0.03310117,-0.023509374,-0.016711244,-0.030952608,0.03977498,-0.053196207,0.01355606,-0.08507884,1.8799071e-33,0.10309854,0.032935217,0.012202772,-0.016588414,0.026552256,-0.025468787,-0.022922404,0.013276711,0.011316597,-0.027024614,-0.11763808,-0.07014274,-0.046816204,-0.010700214,0.033463083,-0.026982976,-0.0779605,-0.0045295516,0.06264184,0.026069663,-0.081075676,-0.010743281,-0.09076427,-0.03039668,0.024929592,0.0996656,0.004042798,-0.05589396,-0.01677795,-0.010268385,-0.020622907,-0.05411621,-0.07720205,-0.06861556,-0.02435183,-0.04368388,-0.0008612043,0.0036707507,-0.096339904,0.057286996,-0.00419408,0.030572705,-0.011819917,-0.06198297,0.084093735,0.028941046,-0.09705006,0.12135235,-0.009974244,0.042272575,0.02703972,-0.031323686,0.08194915,0.07987016,-0.03831448,-0.03305654,0.016848668,0.024982052,0.027442718,0.066484705,0.049412157,-0.00098692,0.008858226,0.08628322,0.04263396,0.05010404,-0.10850536,-0.06273521,-0.024345841,0.1044197,-0.049932465,-0.028575795,-0.0068736733,-0.033554174,0.00014269885,-0.049191058,-0.02153429,0.042050127,0.039794154,0.05024388,0.074931964,-0.023856698,0.0124830045,-0.03138405,-0.06486115,0.0463344,-0.008539637,-0.016404146,-0.0085512465,-0.014422702,0.056347787,-0.01039182,0.026048902,0.027808549,-0.049884357,-2.9273957e-33,0.06663902,-0.059331216,0.035046555,-0.09097689,-0.04117096,0.0088864025,-0.027936693,0.03357605,0.034087647,0.071506426,0.064441964,-0.03330823,0.076199576,-0.028444402,-0.019157555,0.0847487,-0.008526124,0.11560763,-0.020455737,0.068450935,-0.0650762,0.06894466,0.007347686,0.016530251,0.039382085,0.049784757,0.0023021663,0.054905917,-0.01602771,0.028882168,0.015328107,-0.024561087,-0.074597314,-0.016108511,0.008462768,0.050712712,0.03745481,-0.03421817,0.054235414,0.09363626,-0.018364727,0.070567146,0.034581095,0.04417268,-0.010719136,0.060206503,-0.07995298,-0.003340759,-0.028894503,-0.08833349,0.005808511,0.009965559,-0.010165426,0.028743887,-0.04654712,0.015686503,0.034961537,0.0038025775,-0.020661427,-0.06857669,-0.005290128,-0.007490139,-0.029673722,0.061599873,0.00077427557,0.09053952,-0.013726886,0.027273603,0.029350756,0.009414964,-0.0048085325,-0.027901981,0.032953277,0.09213962,-0.04859568,0.058887865,-0.014703017,-0.028073348,0.016056405,0.08466926,0.007424789,-0.017985495,-0.03854613,-0.07649215,-0.015071423,-0.059193704,-0.008885503,0.144914,0.07607241,-0.0018518673,0.030890327,0.039540295,-0.023762727,0.08801407,0.07426746,-4.2225576e-08,0.05117819,-0.13986044,0.0034343528,0.012929631,-0.06269181,-0.014971652,0.041996703,0.0036758347,0.092010766,-0.007459695,-0.03106041,0.03324234,-0.08381776,0.009159051,0.011218794,0.023896564,0.054675557,0.08931799,0.049681906,0.009217514,-0.044237576,-0.035327148,-0.017336218,-0.015640553,0.0049759694,-0.07652452,-0.03348904,-0.015293336,0.08546314,-0.036630817,-0.016116044,0.020449404,-0.03371259,-0.022719054,-0.012030053,0.08374069,-0.0021481134,-0.07571626,0.021999912,-0.026370035,-0.048920196,-0.0678951,-0.05522503,-0.043472316,0.058404073,-0.040680014,0.064927556,0.01936076,0.005371424,-0.033058405,-0.006595748,-0.026480835,0.08496089,-0.12380802,-0.063215904,-0.0022782236,0.018753212,0.0024724442,-0.032859746,-0.07616076,-0.016613254,0.056279838,0.20517312,-0.023821509 +1.14.14.71,Isolated from the plant Siraitia grosvenorii (monk fruit).,384,0.99999994,-0.06337199,-0.00393133,-0.14481787,-0.05265314,0.041205317,0.07330443,0.010422396,-0.027600998,0.020517513,-0.02603558,0.113089025,-0.0449557,-0.005967746,-0.01995733,-0.04937735,0.030565986,0.0062564323,-0.017144298,-0.0049846782,0.026471531,0.035929862,0.05902966,-0.031766377,-0.0007815598,-0.015067947,0.007042438,-0.02251732,0.013973275,0.038350496,-0.09009753,-0.0011502008,0.014409129,0.085971735,0.00038650213,0.024005728,0.061496843,0.023291918,0.030757286,0.10243405,0.030120509,0.03726215,0.04153214,0.060772143,-0.041715425,0.023894457,0.03357355,-0.08087567,0.025108308,0.070806935,-0.06730239,0.0027655289,-0.02610483,-0.004707684,0.0015090205,-0.016117353,0.002845088,0.050212007,-0.04558464,0.009353669,0.070366025,0.0425255,-0.010729012,0.017617678,-0.009519154,-0.056208543,-0.0049673826,-0.10244761,-0.06389491,0.13402104,-0.030462172,0.047565345,-0.044522498,0.006714876,-0.009808609,-0.1140839,0.024839807,0.010068044,-0.015770927,-0.020066071,0.07876598,-0.046378605,0.02140038,0.053748302,0.039602157,0.0024055385,0.016461093,0.03405427,0.02723879,-0.02515603,-0.05001865,-0.02662442,0.035027154,0.0073597045,-0.0414556,-0.034866635,0.013580974,0.036112744,-0.07995208,-0.023383478,0.029707743,0.0105263535,0.0017365995,-0.023655104,-0.10419325,-0.10136259,0.021229306,-0.04774929,-0.051187485,0.06237187,-0.0025479435,-0.053230826,0.04821679,-0.040848732,0.0022356983,-0.052964423,0.0068232715,0.12060362,0.03863563,-0.07142553,-0.00031318926,-0.039619688,0.03298612,0.06772123,-0.047822908,0.018876908,0.017088484,-0.039748233,-2.6665507e-35,0.036382895,-0.040508777,0.011327201,-0.042641602,0.07154415,0.00433557,0.014141504,-0.04993888,0.040992778,-0.060023673,-0.047124512,-0.055061407,-0.08595223,-0.033326875,-0.02023043,0.067232765,0.045316968,-0.023254875,0.08682069,-0.10128886,-0.0019604764,0.06824349,0.006128039,-0.047892418,-0.016111223,-0.013030488,0.07166881,-0.08330847,0.13053283,0.016858606,0.010921165,-0.037473723,-0.029712979,0.0150574315,-0.011520001,0.053262148,-0.07326502,-0.07605559,-0.0020250068,0.07933478,0.026942179,0.010859817,0.104316935,-0.0075983484,-0.024075136,-0.034550056,-0.013212049,0.008401578,0.07869399,-0.01473251,-0.10728195,-0.005323801,0.07536069,0.013101416,-0.0586834,-0.10312954,0.026998382,0.043831956,-0.020815607,-0.0021873412,0.00010188212,0.020714145,-0.020857964,0.031060927,0.025557395,-0.0037813303,-0.14478187,-0.016221156,-0.030160353,0.005565175,0.0036113511,-0.016795617,0.06716095,-0.09770603,-0.00921261,-0.031104226,0.005565882,-0.026292829,-0.01278381,0.034088183,-0.06225301,0.053822108,0.00031714537,0.052883707,-0.05406278,0.0035884797,-5.725159e-05,0.0503147,0.036494862,-0.02188609,-0.008262676,0.0047207843,-0.068828985,-0.016457481,0.0021099013,-7.030818e-34,0.055693757,-0.0012417133,0.04748556,-0.020463126,-0.011339844,0.049426377,-0.083386816,0.07552341,-0.015846098,-0.016558785,-0.057153314,0.015442102,0.042200033,-0.013519319,-0.010494498,0.08170169,0.097674206,0.13503408,-0.084639154,-0.09536702,-0.07279174,0.022928054,0.032854,-0.069483995,0.07019506,-0.007102173,0.04902291,0.035574213,-0.02427211,-0.0012811922,0.050885383,0.022315217,-0.1037707,-0.032448053,-0.040006727,0.036720622,-0.05418127,-0.107241325,-0.0076263556,0.012644051,-0.001452513,0.02729498,0.070929155,0.07812071,0.1264384,0.009123557,-0.0012834235,0.059696585,-0.020537315,0.07420788,0.021388797,-0.020709453,-0.024383308,-0.0023450567,0.0664239,-0.10171478,-0.019709615,0.07161265,-0.05431019,-0.041284487,0.042009074,-0.015366754,-0.15005946,0.01701647,0.02373249,0.15550476,0.033642843,0.053195544,-0.008914443,0.029394578,0.020851528,0.033156585,0.018535016,0.064813286,0.029921433,0.05563614,-0.022923473,-0.056926984,0.0036896828,-0.011068316,0.008920351,-0.023535494,-0.01492771,-0.032823022,0.03861709,-0.045329362,0.003474785,0.022478689,0.02798069,0.0052238237,-0.028436264,0.04935839,-0.10042408,0.010654363,0.0739583,-1.7869192e-08,0.10546562,-0.07026425,-0.01872844,-0.04831307,-0.024765562,0.010840511,0.008266248,0.018375725,0.08172163,0.0007765468,0.002727531,-0.033017542,-0.0009543348,0.014212922,0.03575768,-0.02355608,0.09463033,0.08343186,0.001475586,-0.018881656,-0.09482788,0.012707693,0.01584242,-0.01301997,-0.09448734,-0.032803655,0.03293463,-0.017017405,-0.018054308,0.023595095,0.07540098,0.050380446,-0.045850158,-0.031423714,-0.024334442,0.09790886,0.006964172,0.05993903,0.012927851,-0.014404998,-0.037697837,-0.024422038,-0.07942505,0.018069128,-0.06927927,-0.015496387,-0.034255777,0.036483906,-0.026310379,-0.029536104,0.0072392877,-0.020922888,0.1323955,-0.043924663,-0.12760697,-0.01965875,0.025104702,-0.11111237,0.0056118695,-0.0016644596,-0.044526763,-0.045349665,0.07335087,0.07276706 +1.14.14.72,A cytochrome P-450 (heme-thiolate) protein isolated from the plant Persicaria hydropiper (water pepper).,384,1.0,-0.06822123,0.011962326,-0.04042534,-0.0526872,0.08237181,0.084432505,-0.048624378,0.12548476,0.04464834,-0.06371616,0.07624156,-0.075288326,-0.04842649,-0.01742959,-0.06116537,0.007611754,-0.024264034,0.005932644,0.011579136,-0.098103076,-0.025275586,0.078523815,-0.0077285254,0.0074235564,-0.009249416,0.07070682,0.006745378,0.06342172,-0.024578797,-0.069567546,-0.06266375,-0.033170745,0.067831226,-0.032057445,-0.029412,0.082813434,-0.028186088,-0.07894245,0.055983495,-0.044240817,0.08402961,-0.005801432,-0.055431046,-0.0015420247,-0.06440198,0.0021702338,0.027241085,0.024782885,0.048000082,-0.061190557,-0.003233965,-0.047937308,-0.0026559685,0.039284628,-0.05792076,-0.012068578,0.049984634,0.012168129,-0.026839567,0.02873138,-0.029001733,0.060332846,-0.019114653,0.009909023,-0.010207313,-0.043616768,-0.07260349,0.04414682,0.061288945,-0.07388344,0.009774309,-0.06656561,0.022980154,0.0011025155,-0.09649011,0.10753338,-0.011451919,0.021396765,0.0038024315,0.02845927,0.013145854,0.034397326,-0.014523699,0.10665758,0.009071013,-0.0031232417,-0.027961452,0.06372493,-0.059214927,-0.060434066,0.0011054915,0.023069434,-0.03880174,0.0036068715,-0.08586583,0.104352064,0.02086392,-0.07209296,-0.011779766,-0.02166211,0.03340109,0.054393135,0.0032669397,-0.119294986,-0.007557802,0.016618477,-0.019888267,0.022739448,0.07901901,-0.06733244,-0.02972673,-0.026033487,-0.03372497,-0.027945714,0.015201122,0.015571042,-0.02629955,-0.009144541,-0.02920851,-0.040300492,-0.06482053,-0.027872393,-0.024278421,-0.02289548,0.014936057,-0.01268595,-0.110391356,1.9109479e-34,0.029496366,-0.011294772,-0.001954601,-0.0040486413,-0.015181403,-0.007885686,-0.011395339,0.08745226,0.019006848,0.0015139672,-0.07382468,-0.05724733,-0.05663035,-0.029743489,-0.023728631,-0.02173789,-0.014147783,0.007959067,0.059969794,-0.015093854,-0.018064821,0.027022317,-0.08215133,-0.06535173,0.026397118,0.09135556,0.01993601,-0.11917128,0.02382437,-0.024783177,-0.034521755,-0.03477719,-0.0176,0.0016989472,0.06531424,-0.04031415,-0.0020812498,-0.031168241,-0.09816178,0.0476117,-0.032168094,0.00695469,0.015494015,-0.056410633,0.058454502,-0.017788831,-0.12724991,0.021817788,0.0075558717,0.042485945,0.073786885,-0.03429062,0.09825944,0.05503181,-0.02508731,0.009282461,-0.008652665,0.08708147,0.010529283,0.032724403,0.058771577,0.10975045,-0.06895376,0.058571294,0.09096202,0.0721539,-0.093024544,-0.023296485,0.059191495,0.11034109,-0.05680512,-0.0021071504,0.020273734,-0.054975823,0.042973787,-0.03486286,-0.034722265,0.036920413,0.08549766,0.040887874,0.008466834,-0.023658006,0.03879906,0.019390343,-0.04402477,0.08100894,0.09616867,0.040430676,0.02901571,0.07713037,0.09352138,-0.017347913,-0.012102882,0.020990329,-0.040195674,-3.2691175e-34,0.045166988,-0.042907827,0.016591134,-0.046500176,-0.0023075116,0.08444439,-0.043671485,0.0077050994,-0.022128426,-0.009136578,0.030610574,-0.021450782,-0.0040120343,-0.028938029,-0.015720634,0.0400868,-0.056253664,0.057373088,-0.03978832,0.08142729,-0.08791047,0.010849382,0.07044534,0.050110415,-0.01508586,-0.0127251865,0.10721819,-0.024583481,0.015182273,0.0023810198,0.011615231,0.06658471,-0.02478636,-0.095095135,-0.016372515,0.00076345017,-0.031675667,-0.0015724517,0.07960529,0.066010565,-0.04321968,0.0765953,-0.008851242,0.01853576,0.014757346,0.09346785,-0.044475257,-0.057480436,-0.04824928,0.026293093,0.0488649,-0.051700644,-0.008442074,0.0029743593,-0.026175873,-0.06057705,-0.023171086,0.0013702868,0.005874324,-0.042062014,-0.020240951,-0.060547885,-0.053092502,0.08811716,0.004099308,0.061061714,-0.0027760572,0.058085613,-0.028967636,0.030866997,0.035112258,-0.024651075,0.087887816,0.08825954,0.032278746,0.014504836,0.033951197,-0.041641932,0.05190996,0.017200988,0.0045938957,0.041479975,-0.06818782,-0.09432989,0.015476555,-0.065943725,-0.031833936,0.08445246,0.055298604,0.023543179,0.030403515,0.10210068,-0.056252778,0.016904615,0.15646556,-2.482803e-08,0.013859327,-0.077699475,-0.015302424,0.041040406,0.014837469,-0.00010676631,0.011089523,0.0009558171,0.05002673,0.05145732,0.029411698,0.020543462,-0.078413084,-0.022514712,-0.025379399,0.016412972,0.1037433,0.016945902,0.04401769,0.0660459,-0.08918431,0.029057268,-0.034624428,-0.051132668,0.03571781,-0.077639975,0.06038223,-0.026160413,0.06144049,0.0016964586,0.022046322,0.054272898,-0.035736453,-0.047656097,0.05617712,0.065808505,-0.030801512,-0.06746977,-0.02757467,-0.014879693,-0.0036201456,-0.030912796,-0.029296055,-0.06688844,-0.03196842,-0.02595973,-0.0066950833,0.046879128,-0.031468187,-0.012727642,0.0010766267,-0.010434265,0.077614814,-0.14924166,-0.093218476,0.008632169,0.074095875,-0.020071268,-0.09330369,-0.07850781,-0.020301653,0.002731455,0.10991195,0.0063001066 +1.14.19.54,"A P-450 (heme-thiolate) cytochrome. The enzyme from Papaver rhoeas (field poppy) is specific for (S)-reticuline and does not act on the (R)-form. The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC 1.5.1.27, 1,2-dehydroreticulinium reductase (NADPH), which catalyses the reduction of 1,2-dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline.",384,0.99999994,-0.03910253,-0.028999917,-0.11227429,-0.037784714,0.097059704,0.09277657,-0.07161018,0.08848972,-0.011400319,-0.03290139,-0.012694456,0.042974234,0.0017875119,0.024866022,0.012499182,0.009749177,-0.0831162,0.008042847,0.03299864,-0.066016175,0.029690433,-0.02704072,0.05629084,0.03553715,-0.018136958,0.10760617,-0.03546005,0.044572715,-0.023834947,-0.098461546,0.04811195,-0.010550752,-0.0421885,-0.034228742,-0.022850312,0.08524601,-0.08775885,0.030825423,0.04966634,-0.010296189,0.052161437,-0.0025705681,-0.047563933,0.05394692,0.012390618,-0.0563209,-0.081084944,0.08358503,0.02765887,-0.07724503,0.0076978323,-0.03433072,-0.055878866,0.08656685,0.031211313,-0.035362463,0.015995456,0.016328909,0.011985109,-0.0396375,-0.047186438,0.055958305,-0.027561761,0.004983557,0.008436383,-0.06734725,-0.04662489,-0.035075616,0.014383829,-0.005884282,-0.03371441,-0.05134345,0.0047821035,0.05441282,-0.061180666,0.037598573,-0.049080525,0.007986367,-0.06702748,0.05403758,0.07762268,0.025303407,-0.044164952,0.10379939,0.06905082,-0.042449947,-0.07144727,0.016275408,0.006609508,-0.06324021,0.08989991,-0.0084946,-0.029423468,0.04950982,-0.104946144,0.02370505,-0.012240751,-0.03974298,-0.02530946,-0.021514555,0.026243078,0.02319145,-0.09873826,-0.104096025,-0.05242462,0.008338509,-0.052640636,0.09215053,0.007833542,0.00018501285,-0.024671018,-0.0842109,-0.010776403,0.009301608,-0.071378976,0.07016767,-0.0049247458,-0.023082146,-0.015310596,-0.07148309,-0.022092521,0.015080744,0.04961633,0.0016733359,0.020800352,-0.045009375,-0.1409205,2.2390407e-33,0.04691901,0.058103867,-0.020816643,0.042991217,0.02050779,0.005713626,-0.018099645,0.059608273,0.055122904,-0.041675784,-0.051163346,-0.027493626,0.0018424551,-0.015229631,-0.05301803,-0.052849893,-0.053816058,0.0009907694,-0.020426948,-0.034877747,-0.049262777,0.05732123,-0.054891866,0.0039046695,0.04434839,0.08709527,-0.04199834,-0.014483301,0.049625043,-0.0060108183,0.0075112735,-0.0026022927,-0.10205753,0.021866193,0.06879039,0.024417082,0.013126988,-0.04959256,-0.05972154,0.009460193,-0.04792027,-2.1538612e-05,0.04472571,-0.03926573,0.04390064,-0.08718081,-0.09799995,0.06966296,0.033842776,0.052628454,0.07208171,-0.040502008,0.057639744,0.020186674,-0.09023556,0.027114237,-0.049167693,0.011398143,0.040541835,0.05805936,0.11218474,0.008282761,-0.020070823,0.007561359,0.03844764,0.039630644,-0.062244676,-0.06722303,-0.012795385,0.18765739,-0.02546435,0.013097225,0.07924365,0.014237889,0.065754294,0.0018799141,0.010417955,0.10905689,0.06641689,0.01245423,-0.022633506,-0.049661234,-0.033544302,0.008803927,-0.024330746,-0.0015102336,0.06210736,0.0063960026,-0.018587865,0.019106759,0.067611836,-0.073265955,0.003649716,-0.0121564865,-0.05292668,-2.3126995e-33,0.051823184,-0.070335716,0.072587185,-0.031918515,0.0006974681,0.056929536,0.032689784,0.031124884,0.023478566,0.042070743,0.0627164,-0.01675306,0.037665956,0.016330322,-0.0026456497,-0.009463659,-0.02442397,0.08733497,-0.032880835,0.031562455,-0.07799024,0.10379972,-0.0032508408,0.061979625,0.0102163255,-0.011277896,0.037949655,0.031721573,0.04906885,-0.033402886,-0.0075895875,-0.017961906,-0.11391298,-0.024817374,-0.06732601,0.118050456,-0.0031434828,0.009640981,-0.04426604,0.047779385,0.0060840156,0.035845306,-0.020805566,0.038953375,0.04083496,-0.01668812,-0.091207385,0.08920578,0.08240467,-0.0519946,0.035984594,0.004955535,-0.011492388,0.025238767,-0.01476664,-0.041592903,-0.014338349,-0.025033996,-0.028470093,-0.05608909,-0.005512282,-0.020891888,-0.070352286,0.010221081,0.06180775,-0.0067851967,0.004795367,0.033571806,0.07081894,0.054417558,0.04135066,-0.00468951,0.07889616,0.07577784,-0.0046213614,-0.062409043,-0.05305625,-0.08116076,0.0415844,-0.03043762,0.05562719,-0.025365371,-0.008056596,-0.030266048,0.012507408,-0.0103866635,-0.003955672,0.09279933,0.039261855,-0.03846931,0.026090391,0.010168765,-0.014494905,0.13923462,0.0657019,-4.3750646e-08,0.04765435,-0.025635969,0.029511655,-0.008676258,0.023031818,0.00836237,0.03579149,-0.08923738,0.014182915,-0.07629913,-0.010871787,0.055830266,0.0065679005,-0.0006157005,0.024026992,0.020953337,-0.009926449,0.10661597,0.021854836,0.01779685,-0.05010526,-0.019139389,-0.06284766,-0.002004009,0.057363536,0.016082687,0.038184233,0.02464315,0.012972773,0.0059189517,0.05133544,-0.006276679,0.011224741,0.009844391,-0.044014424,0.038252607,-0.012088164,-0.018412597,-0.033953533,0.0021678011,-0.00060539815,-0.05120822,-0.08161545,0.01312969,-0.0329723,-0.05261327,-0.0029041562,-0.021268219,-0.040664572,-0.021240894,0.020821704,0.010947909,0.018469242,-0.14784507,-0.10823333,-0.034330066,-0.026173417,-0.034830615,0.0010772441,-0.119802184,0.040897716,0.02607393,0.20485218,0.051548045 +1.14.19.55,"Contains FAD. The enzyme, described from epiphytic marine bacteria of the genera Pseudoalteromonas and Marinomonas, is an unusual single-component FAD-dependent halogenase that contains a distinct NAD(P)H binding domain and does not require an additional flavin reductase for activity. The enzyme catalyses a bromination of its substrate, followed by a second bromination concurrent with decarboxylation.",384,1.0,-0.046910577,-0.05381942,-0.11713074,-0.07125328,0.07827081,0.07106136,-0.118299335,0.026263729,0.047943503,-0.015635144,0.009356236,-0.07566083,-0.05709352,0.05410996,-0.0630197,0.010986921,-0.092246756,-0.044007983,0.054240525,0.029973099,0.0037564195,0.0823398,-0.03683783,0.021305291,0.036478963,0.06925944,0.08360501,-0.04303806,-0.027375417,-0.036275793,-0.0032345525,0.03404873,0.10366137,-0.04481098,0.06488805,0.09810517,0.024463173,-0.04013848,0.08021948,0.029136973,-0.0072300276,-0.02579478,0.044519383,-0.035951044,0.027095914,0.0042287977,0.021105053,0.06562762,0.034724623,-0.013098046,-0.0047305427,-0.06374302,-0.03845865,0.01458239,0.030067766,0.07029817,0.0019006113,-0.05961652,-0.013039527,-0.054507386,0.019115198,-0.021301612,-0.010209443,0.032209847,0.016056744,-0.03878739,-0.0021501184,-0.07919377,-0.0061169453,-0.049731854,-0.03454156,-0.035992667,-0.020174427,0.044411324,0.0075119,-0.0012841712,-0.033797294,-0.0831552,0.036879327,-0.015422854,0.03890393,-0.0007165919,0.04993323,0.073053725,0.07013019,-0.031897664,0.030685175,-0.0015042906,0.024802914,0.043197844,-0.013344342,-0.042009518,0.022474676,-0.05626219,-0.10264195,0.03915288,0.0025559235,0.024985975,0.008457847,-0.04514664,0.01861728,0.009276998,0.00330498,-0.05467571,-0.07235062,-0.011019661,-0.010550858,0.14555751,-0.035564713,-0.040930983,-0.020863347,-0.008071953,0.011899958,-0.0810408,-0.031384602,0.064520635,0.057522953,-0.13233638,-0.085403785,0.005866497,-0.0340975,-0.038521286,0.06397041,0.09440569,0.042446725,-0.013349892,-0.15866394,3.7944047e-33,0.106236026,-0.021258663,-0.020174306,-0.07641026,0.033754654,-0.01006495,-0.06130292,-0.04181809,-0.023013817,-0.07889336,-0.026085086,0.04079242,0.025727637,-0.025722882,0.041953728,0.020665372,-0.039528914,-0.019959334,0.022988558,-0.03932026,0.0022237878,0.103340596,0.0024537856,0.0313919,0.059037223,0.0036532648,-0.008668263,-0.000166039,0.027669229,0.023789441,0.036948618,-0.105858214,-0.0738238,0.030006496,0.050348148,0.020882336,-0.030200858,-0.06767076,-0.09658081,0.07335238,0.01000462,0.04001019,-0.008580535,-0.0015134814,0.02192057,-0.14022936,-0.020975135,0.08052691,0.05350643,0.098541245,0.052249283,0.003745299,0.080744624,-0.030837225,-0.047052823,0.05699263,-0.04914352,0.028346276,0.07099758,0.030226879,0.036835443,0.00060527987,-0.013723562,0.0997167,-0.016512282,0.009361922,-0.011650969,-0.07301656,0.05664316,0.10587778,-0.030935688,-0.041474164,0.06786775,0.027831769,0.063522875,-0.08059713,0.001036558,-0.013016461,-0.025254667,-0.021121273,0.011973176,-0.015288781,0.026690558,-0.032299217,-0.075450845,0.059574224,0.012064137,-0.06145801,-0.019988094,0.048391886,0.053678162,-0.071015395,-0.020018399,-0.0033895797,0.040828317,-3.3326977e-33,0.056754794,-0.10387854,0.025786603,-0.061228674,-0.05863562,0.107592165,0.0145843765,-0.04949219,0.030063184,-0.069128074,0.031382937,0.036867168,0.0014281609,-0.013340327,0.056423865,0.020100165,0.044922233,0.0018999876,-0.009066498,-0.025447052,0.028062522,0.040815804,0.04791879,0.032559488,-0.023348818,0.029185757,-0.06988889,0.062427722,0.048355374,0.060146157,-0.06402992,0.06518869,-0.048105292,-0.06386683,-0.100708604,0.008112761,-0.054177176,0.046037726,-0.00094489567,0.032848686,-0.025831392,-0.023391334,-0.03946026,0.03128328,-0.00803485,0.03136862,-0.030617038,0.005879364,0.066198945,-0.12204418,-0.022085186,0.035979893,0.03415269,0.023538427,0.046345342,-0.010655935,-0.012949332,0.06918532,0.04569595,-0.014232061,0.019124357,-0.08326636,0.035826705,-0.0020433897,0.102074265,0.019321881,0.0023491033,0.037239548,-0.012243011,0.04474221,0.028318236,0.02521015,0.0179269,0.12283699,0.018077252,-0.01711005,-0.05604629,-0.0041605346,0.016432812,0.05809123,0.02140073,0.008333072,-0.034770805,-0.053555947,-0.0507671,-0.10491881,0.03294901,0.043398753,-0.047576025,0.017941417,0.018231696,0.031805377,0.0033893553,-0.026525542,0.06028127,-4.0521257e-08,0.02545724,-0.047565237,0.030193418,-0.03775912,0.020877035,0.05045653,0.031973444,-0.049255025,0.037903786,-0.08266138,-0.0063019875,0.05426009,0.07354833,-0.029388959,0.07407813,0.003961403,-0.02873121,-0.0052457377,-0.06397631,-0.00866216,-0.07084684,0.046486437,-0.07847402,-0.011630704,-0.035104644,0.029278407,0.038177334,0.014170562,0.023635965,0.018780673,-0.046577465,0.027749175,0.014793428,-0.08156842,-0.09966954,0.04124321,-0.011272709,-0.028733147,-0.11627814,0.039153174,0.018726131,-0.041061357,-0.06955837,0.009626206,0.0026151799,0.08570334,0.039379463,0.011096198,-0.051029135,-0.038805485,0.07669985,-0.032674156,0.012100645,-0.02912448,-0.11116943,0.04028129,0.023170581,-0.13432418,-0.046553917,-0.039288033,0.007943175,0.028327256,0.13149971,0.02409732 +1.14.19.56,"The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a flavin-dependent chlorinase that participates in the biosynthesis of the antibacterial and antifungal compound pyoluteorin.",384,0.99999994,-0.08545945,-0.063726984,-0.13425013,0.0031071545,0.09109993,0.052645188,-0.030250488,0.04470644,0.01995372,-0.01828609,0.04494865,-0.04850551,-0.117496565,0.121727176,-0.08355568,0.025182026,-0.1001839,-0.011204091,-0.0059966724,-0.011291131,0.025856141,0.0750122,-0.028457893,0.047140434,-0.051244654,0.03228769,0.047565613,-0.012912991,0.011653901,-0.02196152,-0.04257604,0.03201069,0.105197065,-0.07133176,0.036237188,0.06993341,-0.042061064,-0.048827227,0.07138062,-0.02086159,0.002586285,-0.03940527,0.003171865,-0.033149578,-0.010827314,0.028690213,0.019036703,0.05965552,0.09592298,-0.019461263,-0.03976939,0.02137608,-0.07890854,-0.0110439835,0.0034560207,0.038047828,0.024653565,-0.081771396,-0.056588348,-0.053722877,0.018187022,-0.023009852,-0.007403583,0.06371835,-0.036168713,0.012904591,0.00511908,-0.043030802,0.029224716,-0.073157944,-0.06884087,-0.04733005,-0.0009578634,0.028953314,0.020495085,-0.010105268,0.03001395,-0.045329005,-0.033192348,-0.036224134,0.08153468,-0.035371903,0.041789297,0.06782054,0.041451395,-0.08352436,0.0051124645,-0.016139708,0.07184608,0.009678982,0.02086632,0.022095395,-0.013572706,-0.043240447,-0.111351155,0.09120467,-0.03993611,-0.034668237,-0.0142077245,0.0016686656,-0.014846107,-0.027030952,0.038925733,-0.066183686,-0.02950659,0.008522683,-0.014866269,0.041190628,0.053699564,-0.017007222,0.005933728,0.050463233,-0.0037342464,-0.10089024,-0.009142704,0.033920825,0.026227182,-0.04677951,-0.050309017,0.056731712,-0.009493655,-0.02460403,-0.004693601,0.06958712,-0.041086145,-0.021713374,-0.12549247,2.6638118e-33,0.02243204,0.010170027,0.022811795,-0.028901702,0.0173476,-0.026867308,-0.011683684,-0.06336478,-0.029575331,-0.11304155,-0.0105431285,-0.050760116,0.001424876,-0.03922191,0.025786685,-0.029460361,-0.038044967,-0.031744875,0.05557325,0.03415258,0.050669786,0.07345605,-0.06769797,-0.00072334276,0.09372747,0.06753815,0.015224133,0.047143783,0.0024761255,-0.0059549715,-0.0050522587,-0.05038523,-0.06477928,-0.035037536,0.04198888,-0.027446205,-0.042632945,-0.06339999,-0.028750248,0.004885404,0.012366782,-0.022952562,-0.003853908,0.022964345,0.04015354,-0.074240915,-0.07357637,0.11849134,0.027058126,0.12744445,0.019114884,-0.029733127,0.060031172,0.06616004,-0.04123264,0.027895628,-0.00779013,-0.008178599,0.0008308274,0.0279884,0.07283813,0.04044531,-0.08058447,0.016318668,-0.02768275,-0.014965563,0.04396338,-0.0755014,0.096267805,0.02857067,-0.08250314,0.0048235944,0.02400612,0.07036581,0.047254797,-0.06813173,0.0026948475,0.025999982,0.022182852,0.0478895,-0.053426463,-0.008012394,0.09358865,0.03046269,-0.11894402,0.008309913,-0.01234082,-0.019926185,-0.023997068,-0.04783693,0.07950449,-0.11187927,0.018705357,0.080126055,-0.024270123,-3.398735e-33,0.06262303,-0.1311774,0.072730534,-0.0046533006,-0.049716353,0.049155794,-0.029173004,-0.012876322,-0.026606468,0.025429899,0.06152841,0.00024493548,0.0050266176,-0.050658815,0.07519638,0.06330877,0.058334995,0.011560752,-0.043616146,0.023307472,0.022121808,0.07440328,0.03496745,0.034214467,0.0061344854,0.03698725,0.019464303,0.016949574,-0.0042815777,0.06096813,-0.06498146,0.022547876,-0.050938345,-0.060679194,-0.006817615,-0.04135378,0.0032165034,0.0016869133,-0.01802794,0.03292385,0.030375298,0.08446745,-0.0052468623,0.02517979,-0.09053379,0.08974724,-0.048457216,-0.0024015403,0.0008847793,-0.11400021,-0.030637182,0.08015354,-0.018618349,0.031057239,-0.014963125,-0.029489733,0.024536911,0.024847398,0.0011068163,0.015637195,-0.032350875,-0.13004151,0.04384659,0.019223418,0.08373808,0.08858518,-0.012500364,0.05603506,0.06550014,-0.023983346,0.041602246,0.04981221,0.05377019,0.09143395,-0.076170266,-0.00094002316,0.0068920613,-0.01420075,0.03502662,0.043788027,0.04205707,-0.06610427,-0.016106097,-0.045940567,-0.07075232,-0.14330341,0.044691943,0.038839694,-0.012829576,0.034386948,0.013746879,0.007994274,0.013486927,0.024606211,0.052489858,-3.2444802e-08,-0.017383913,-0.075251676,0.014494575,-0.047704183,0.009426265,0.04560594,-0.009106047,-0.04636015,0.028561028,-0.011459036,-0.03403542,0.026982456,0.015501337,0.0073488373,0.023405634,0.038034398,-0.06485884,0.013999673,-0.009455328,0.0103040505,-0.035111595,0.011034731,-0.15934683,-0.007916875,0.019993132,-0.022877056,0.035889227,0.02404288,0.021295551,0.01321531,-0.05170745,0.011377154,-0.041543897,0.016832339,-0.09283071,0.054351397,0.030527027,-0.092449695,-0.096773185,0.087486,0.032199223,0.020105945,-0.07111928,0.017092543,0.04096064,0.004508955,0.023846844,0.014315349,0.02940774,-0.07088157,0.09008397,0.03694593,-0.029119207,-0.02959985,-0.13075423,0.0145672215,0.04311668,-0.03181875,-0.049504455,-0.025407191,0.0046395054,-0.00840662,0.17230639,0.045734577 +1.14.19.57,"The enzyme, characterized from marine bacteria of the Pseudoalteromonas genus, belongs to a family of FAD-dependent halogenases that act on acyl-carrier protein-tethered substrates. It catalyses three successive rounds of bromination. While the order has not been verified, it is believed to resemble that of EC 1.14.19.56, S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] chlorinase, due to significant sequence homology. Reduced FAD is provided in situ by a dedicated reductase and diffuses into the active site, where it reacts with the oxygen and bromide ion, resulting in formation of a bromoamine intermediate on a catalytic lysine side chain, and the eventual transfer of the bromide to the substrate. The enzyme from Pseudoalteromonas luteoviolacea 2ta16 is specific for bromide and does not accept chloride.",384,1.0,-0.073003724,-0.07519709,-0.13429421,-0.06878007,0.11635064,0.06798844,-0.06576601,0.0642229,0.054351237,-0.0013816762,0.057080176,-0.041153386,-0.0066969227,0.066385075,-0.04698683,0.023858458,-0.11598524,-0.038526338,0.019650886,-0.013318769,0.0006097664,-0.0043978733,-0.08488701,0.045026965,0.0035318327,0.05052381,0.07170678,-0.058067057,-0.06663004,-0.029088309,0.017070882,0.016661711,0.09817718,-0.038627088,0.06116128,0.06207466,-0.0064666825,-0.055692807,0.071373336,0.03336177,-0.03039594,0.027278824,0.03295269,-0.056337785,0.001465536,0.0029302305,0.04248491,0.029195867,0.018585224,-0.04648897,-0.0008717525,-0.053676438,-0.042430196,0.04369009,-0.04877362,0.06585214,-0.06737092,-0.031545,0.034933623,-3.151937e-05,-0.00048299733,-0.047496784,-0.008187021,-0.014967891,-0.036966696,-0.08050235,0.0007316186,-0.10154828,0.016381472,-0.033887673,-0.019419303,-0.024907133,-0.03131223,0.061782833,0.031976663,-0.0026898596,0.0065686563,-0.071310356,0.008259133,-0.022736333,0.0064417035,-0.045091685,0.06632145,0.069149025,0.04062087,-0.04224921,0.03489386,-0.03798015,0.021287872,0.04414316,0.027795961,-0.00659706,0.005253704,-0.036089454,-0.09527451,0.07361851,0.0076710796,0.07228563,-0.008308941,-0.04497142,0.027393738,-0.00034875041,-0.04382746,-0.08259348,-0.05730958,-0.016671168,0.01903023,0.14234349,-0.03554822,-0.056616195,0.0025168927,0.057933424,0.049721673,-0.04250443,-0.05307582,0.14267945,0.065337464,-0.12356517,-0.04527839,-0.002363862,0.010110233,0.0066423235,0.08216641,0.08741141,0.02143501,0.024940515,-0.11723755,2.9418664e-33,0.03524128,0.002663915,0.008925412,0.007219515,-0.02745977,-0.0808652,-0.08329712,-0.03486128,-0.0076770703,-0.082640916,-0.042063925,0.04508606,-0.0047039776,-0.07656703,0.0035889326,-0.06974851,0.01564687,-0.047713213,0.030836254,0.010835228,0.005257883,0.084682934,0.017840672,0.026526783,0.10437324,-0.031402055,0.03075823,-0.025567517,0.036784243,0.022600977,-0.024193268,-0.066699095,-0.076729715,0.02238643,0.011059329,0.04304291,-0.04026468,-0.05586324,-0.044051472,0.03790282,0.027291652,0.03162566,-0.04079846,0.020419935,0.030178161,-0.08530243,-0.029735489,0.06277661,0.050020646,0.104862146,0.02718935,-0.03292613,0.08148287,-0.032395974,-0.055547893,0.056802925,-0.054832123,-0.052685577,0.07705273,0.05188721,0.04773652,0.04685217,-0.053742122,0.059807383,0.0045595784,-0.022123177,-0.017876204,-0.080406964,0.0043250034,0.07542009,-0.054212146,-0.024211217,0.11143836,0.010170646,0.10408721,-0.10694354,-0.018971024,0.012794604,-0.021221377,0.0058693946,0.041692276,0.030456563,0.059652608,-0.011589442,-0.07725556,-0.015920537,-0.0044042105,-0.04064973,-0.0054469565,0.026887396,0.031398725,-0.11245803,0.012393649,0.04911675,-0.015459822,-2.6700043e-33,0.06459554,-0.15469292,0.04669031,-0.02515457,-0.060016036,0.11604104,0.048436426,-0.00863223,0.034075122,-0.07534646,0.053798005,0.048358932,-0.035819266,-0.0065338803,0.05040893,-0.00685675,0.004046223,0.0066612926,-0.031909186,0.004250755,-0.045073185,0.044521138,0.047571663,0.057008535,-0.00016129715,0.034372963,-0.048132792,0.07006228,0.082206346,0.041384812,-0.07453864,0.017629819,-0.013805585,-0.006815054,-0.09910272,0.026786933,-0.024825204,0.05674353,0.005057983,0.045350317,-0.029229296,-0.022086674,-0.048747685,0.011913578,-0.029304666,0.046291895,-0.034914725,0.00076927594,0.023988614,-0.13525565,-0.024925688,0.00924339,-0.01326222,0.007673511,0.07751804,0.0137161305,0.0024950737,0.04990956,0.016571505,-0.0070807557,0.011965657,-0.06497414,0.014284698,-0.02699637,0.052680027,0.060872816,-0.06995035,0.03880946,0.02731813,0.041845147,0.027362878,0.03158029,0.03920617,0.063319184,0.041300904,-0.03185825,-0.024508951,-0.020292481,0.0073472774,0.0189567,0.0014980094,0.011225611,-0.015826939,-0.04777972,-0.016250707,-0.09840597,0.038802586,0.038477447,-0.042865973,0.0010398277,-0.0011970649,-0.006649808,0.056563053,0.07002633,0.09441576,-4.6010584e-08,0.014231311,-0.04598944,0.052477222,-0.043295845,0.0059543126,0.05826186,0.027294997,-0.05350338,0.046933196,-0.10101951,-0.06931559,0.058056906,0.08909821,-0.012072463,0.005854368,0.055660248,-0.044274874,-0.016308725,-0.009380129,0.016619377,-0.065052904,0.037855223,-0.11550543,0.008143749,-0.020267898,0.013447675,0.049448952,0.059888232,-0.015647886,0.0024454957,-0.0167662,0.0022501044,-0.0039666155,-0.004057169,-0.02342767,-0.012332795,-0.049689345,-0.02614194,-0.04576884,0.06571736,0.017342912,0.01502184,-0.085456826,0.02863036,0.06815713,0.047681853,0.019302001,0.016365908,-0.027206732,-0.0042867805,0.08461581,-0.021233238,-0.0066688266,-0.029277325,-0.100668624,0.034305383,0.02307385,-0.1492663,-0.032519273,-0.06886577,-0.010847981,0.028529331,0.09890406,0.0446467 +1.14.19.58,"A flavin-dependent halogenase. The enzyme from the bacterium Streptomyces rugosporus catalyses halogenation of the C-5 position of tryptophan during the biosynthesis of the antibiotic compound pyrroindomycin B. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. cf. EC 1.14.19.59, tryptophan 6-halogenase and EC 1.14.19.9, tryptophan 7-halogenase.",384,1.0,-0.050365902,-0.01233632,-0.1671796,-0.024455825,0.115808375,0.063497916,-0.033472445,0.05547705,0.06545557,-0.02633645,0.015430583,-0.07184389,0.022036988,0.12254959,-0.06459578,0.002044093,-0.05163029,-0.025849704,0.03000287,-0.03880679,0.029466193,0.075418495,0.013645072,0.010961683,-0.016763864,-0.00520671,0.067856185,-0.021718353,-0.07703525,-0.035169583,0.05397741,0.02497002,0.07479569,-0.0547123,0.09063948,0.102094635,-0.023182584,-0.058154803,0.13719755,0.02189242,-0.078349166,0.014267934,0.03574785,0.005551583,-0.039007604,0.04061562,0.09863204,0.08247766,0.021079805,-0.01121005,-0.028781619,-0.023245865,-0.060569614,0.003968102,0.058244508,0.06482567,-0.079942256,-0.046281002,0.012296452,-0.04447941,0.0066185524,0.01148447,0.023857107,0.0084760785,-0.044792343,-0.046236522,0.013881373,-0.10662344,0.055035807,-0.033750724,-0.06152923,0.005737828,-0.0027337754,0.014120926,0.0056848126,0.02127437,0.014873121,-0.05761863,-0.028850155,-0.06582356,0.010443901,-0.02940095,0.05705237,0.11558225,0.062181976,-0.06694707,0.0032111409,0.029843025,0.036517847,0.054424576,0.09277809,0.008448894,-0.0027543525,-0.04524495,-0.06538918,0.033397477,-0.01916003,-0.023936843,-0.018531049,-0.025676414,-0.020390352,-0.05077908,-0.027031647,-0.034655247,0.007301994,-0.034206312,0.056175712,0.09397668,0.047478344,-0.044392224,0.02900552,0.007928454,0.034153387,-0.054172423,-0.020262832,0.0920778,0.08922915,-0.113856606,-0.16065493,0.072947934,0.025487602,0.054821584,0.023179863,0.067678526,-0.0408813,-0.0020355177,-0.10883536,3.7781685e-33,0.054238457,0.00722392,0.039034717,-0.024829853,-0.015653467,-0.03652981,-0.049512736,-0.05398479,0.011342056,-0.064114705,-0.06067127,-0.039196122,0.019358883,-0.043545596,0.023668176,0.0047856364,-0.08101785,0.022228472,0.019401819,0.0084651075,-0.019237254,0.040353272,0.02493033,0.0072555197,0.07852053,0.09142411,-0.0057569,0.01722609,0.0893911,0.003426579,0.0005249636,-0.04106159,-0.062476233,0.011691857,0.026299741,0.013971367,-0.08916431,-0.025939602,-0.0304544,0.04586746,-0.052984547,0.07724483,-0.067762926,0.0095803,0.075453766,-0.07160233,-0.025639387,0.12998436,0.081050016,0.07658676,0.024614466,-0.021174138,0.048430085,-0.047248255,-0.082752295,0.01915108,0.0016543736,0.0151733775,0.07912075,0.015166825,0.037291076,0.024594245,-0.032013644,-0.021607442,0.07271653,-0.0028098514,0.0044279704,-0.06253241,0.0026329937,0.034330636,-0.03773575,-0.030483332,0.076115005,0.038542863,0.00613922,-0.01376094,-0.03342117,-0.038790725,0.029215705,-0.018233035,0.07382843,0.01217327,0.05461685,-0.06266954,-0.085194446,0.026505616,-0.029491782,-0.082926825,-0.024902156,0.0027154644,-0.009436507,-0.08590021,-0.01209286,-0.030743951,-3.2511558e-05,-4.5141536e-33,0.051688205,-0.08284662,-0.024968857,-0.012390111,-0.025854167,0.1064892,-0.030105421,-0.105093345,-0.03504074,-0.035365008,0.047441915,-0.035607714,-0.025570165,-0.042593155,0.058465067,-0.006842389,-0.0114613585,0.11279884,-0.0015592411,0.024398344,0.05024652,0.025469203,-0.002269884,0.02420466,0.0011076935,0.072449155,-0.033321116,-0.0029990552,0.0784239,0.07957071,-0.048580464,-0.022734001,-0.049219523,-0.041893627,0.00138209,0.033824686,-0.10321563,0.042698685,0.016205905,0.016679903,0.029586822,-0.019129097,0.064359516,-0.026856896,-0.033455532,0.038119856,-0.07301432,-0.009248221,0.02507765,-0.10502086,-0.036718678,0.00120475,-0.07673279,-0.024786465,0.02366152,0.031287733,0.042203497,0.043289084,0.04958206,-0.062325586,-0.08289349,-0.024198692,0.03681692,-0.009948414,0.009670272,0.056348905,-0.016106907,0.059277166,0.0750543,-0.0016196858,0.044400994,-0.008858543,0.09546762,0.016654447,-0.061604965,0.01106261,-0.016396603,-0.035760652,0.008259122,0.05065236,0.027852993,0.044912785,0.029501246,-0.01035216,-0.02585301,-0.11242401,0.05209868,0.015206441,0.019571045,0.028616454,0.013014739,0.002950363,0.05654807,-0.020427568,0.06058686,-4.1925755e-08,0.0030128032,-0.050279006,0.06548573,0.011489946,-0.0007886982,0.020851377,-0.0089116255,-0.028387422,0.049466815,-0.075209536,0.030431902,0.010257455,0.08844205,-0.039244123,-0.0014038496,0.02011776,-0.078368954,-0.051267937,-0.024880825,-0.022627253,-0.14898255,0.004262895,-0.067944564,-0.021312525,0.050933886,-0.015794514,-0.03999964,0.022915844,-0.02231967,-0.0024612595,0.023568539,0.022597525,-0.038686484,-0.03964744,-0.077878475,-0.024933811,-0.047710836,-0.005318059,-0.027968664,0.029530395,-0.012024705,-0.01242184,-0.07680968,0.04933261,0.02075482,0.010480246,0.019482683,-0.015940016,-0.068064965,-0.0058908756,0.079019286,-0.009576725,-0.03660425,0.01015509,-0.09897287,0.039782166,0.025853105,-0.101876035,-0.049724285,-0.10477205,0.019368695,0.021189447,0.12496236,0.028989512 +1.14.19.59,"The enzyme is a flavin-dependent halogenase that has been described from several bacterial species. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.9, tryptophan 7-halogenase.",384,1.0,-0.07526041,-0.0072414028,-0.13898072,0.010626612,0.11231393,0.06108162,-0.036171,0.053427685,0.016720831,-0.02682916,-0.004882313,-0.11867086,-0.040244922,0.1275542,-0.09809374,0.048630327,-0.025337648,-0.034368336,0.018462952,-0.052901585,0.012184191,0.06054192,-0.020545378,0.014929519,-0.029226448,0.0110137,0.055076633,-0.061317507,-0.043675378,-0.030238751,0.01652709,0.00398819,0.10728942,-0.0199197,0.03956423,0.10427381,0.0048530307,-0.08567651,0.08669638,0.03270457,-0.05766582,0.0391196,0.014540282,-0.03511991,-0.0071825744,0.034143157,0.071656235,0.035761528,0.017977366,0.059380487,0.0031805898,-0.03596736,-0.043520655,-0.019652184,0.05089034,0.033485916,-0.0780101,-0.044493582,0.00089114555,0.010964729,0.0031055012,0.032983806,0.027107395,0.031313315,0.020669011,-0.06882824,-0.009948252,-0.10151787,0.032380514,-0.089444965,-0.023529261,-0.046561077,-0.011207819,0.012955135,0.0010246811,-0.0088034505,0.045955665,-0.03632849,0.03780547,-0.033116497,0.0117975725,-0.0025478296,0.0379457,0.11570854,0.038550578,-0.059347954,-0.01946663,0.017793428,0.024226291,0.029042171,0.06290923,0.02086178,-0.025089256,-0.04776491,-0.047099065,0.053300492,0.004223599,-0.015202807,-0.025588745,-0.010766864,-0.017297452,-0.015438613,-0.0019079935,-0.055460386,-0.024352059,-0.053499345,0.044991225,0.10158794,0.044696145,-0.033382658,0.036339138,0.014169418,0.048237037,-0.033301245,0.011486252,0.100415446,0.013701608,-0.12095735,-0.10688666,0.080062374,0.026321355,0.003127335,0.025699101,0.0807845,-0.02024008,0.01626683,-0.1235011,1.3352068e-33,0.07922036,-0.022525232,0.024746679,-0.021717662,-0.047920253,-0.05337749,-0.04355515,-0.03350748,-0.043799073,-0.06992646,-0.005794026,-0.0032188676,0.058325212,-0.03698802,0.022014692,-0.017112667,-0.075427,-0.023092287,0.03219457,0.028943121,-0.029842928,0.055839684,0.01683232,0.014167764,0.046390392,0.05578213,-0.011226494,-0.021475947,0.09429785,0.025798565,-0.00082022743,-0.044846993,-0.04292665,0.0020095878,0.004277928,0.03491671,-0.077035636,-0.025017066,-0.0939175,0.056283973,-0.03132577,0.0788167,-0.05953535,-0.01635195,0.07293849,-0.07279776,-0.050606664,0.11237939,0.07499627,0.09957039,0.03158164,-0.0069635618,0.04850236,-0.04433474,-0.07431804,0.07535273,-0.014470134,-0.015038177,0.06905947,-0.008448899,0.03235923,0.01552631,-0.08504704,0.029959695,0.0639334,-0.023629664,0.019673591,-0.09398694,0.012770017,0.05252682,-0.04881349,-0.043158397,0.08334285,0.039168198,0.00086535426,-0.045872293,-0.025247503,-0.01666664,0.023955004,-0.024848593,0.0731632,0.0023455922,0.104559794,-0.060977686,-0.06928245,-0.00438245,-0.0046756426,-0.06490718,-0.0499039,-0.03104007,0.061792467,-0.080983244,-0.019535037,-0.047745556,0.0032079367,-2.130816e-33,0.053911656,-0.11502061,-0.052681506,-0.026257671,-0.019556297,0.10174647,-0.032465216,-0.076874234,-0.026249744,0.011941989,0.06865113,-0.036291767,0.035982016,-0.017332248,0.09646727,0.031211086,-0.035635706,0.070390835,-0.008968089,0.018399308,0.05684628,0.006690598,0.04500836,0.00088134053,0.00700854,0.042434905,-0.06757901,0.01311941,0.07627749,0.03690757,-0.10744354,-0.012046673,-0.028720059,-0.043471113,0.010068292,0.008060138,-0.07546335,0.027757498,0.0039257263,0.0056744777,-0.0035477106,-0.010306548,0.055135358,-0.036711138,-0.04587477,0.10487649,-0.058740865,-0.011069615,0.027679505,-0.106019005,-0.03330345,0.0006174262,-0.081919625,-0.014403449,-0.00043621744,0.038857933,0.011943117,0.06165033,0.02737026,-0.033504546,-0.040077828,-0.041497532,0.050948318,0.023336178,0.024444945,0.057906177,-0.030889858,0.042905804,0.007578173,-0.012848538,0.043240536,-0.016461916,0.11653165,0.047745027,-0.048193645,-0.061777208,-0.030303648,-0.020900995,-0.011224878,0.034570657,0.045477945,0.04668467,0.04174083,0.016541015,-0.001405763,-0.13898262,0.04217921,0.059223033,0.0034464274,0.041451894,-0.012981228,0.008627968,-0.005284858,-0.030718787,0.086161554,-4.0757623e-08,-0.03569458,-0.08115952,0.055482507,-0.020545071,-0.0018176938,0.07188052,0.012589042,-0.032891486,0.032943062,-0.0667152,0.026318843,0.04445514,0.055695526,-0.021570044,0.02568489,0.024446784,-0.033434764,-0.032621324,-0.02004539,-0.01513097,-0.121533744,0.012683477,-0.012117454,-0.025959117,-0.021511462,0.0029036105,-0.022194857,0.056293484,-0.014623007,-0.040827226,-0.047242247,0.05725562,0.0014873088,-0.07476911,-0.12542503,0.018805679,-0.006727799,-0.013341689,-0.061605006,0.056321852,-0.0019885723,0.0028338411,-0.07662688,0.02737454,0.076001815,0.013981604,0.06229339,-0.00734878,-0.014624311,-0.015426393,0.05661764,-0.031062469,-0.040792286,-0.010873954,-0.056860868,0.030440468,0.015108615,-0.12872049,-0.018810319,-0.08279156,0.026638264,0.07268427,0.15785459,0.04167787 +1.14.19.60,"An FAD-dependent halogenase. The enzyme, characterized from the bacterium Kutzneria sp. 744, works in tandem with EC 1.14.19.9, tryptophan 7-halogenase, (ktzQ) to generate 6,7-dichloro-L-tryptophan, which is incorporated as a pyrroloindoline in the kutznerides family of natural products. It has a 120-fold preference for 7-chloro-L-tryptophan over L-tryptophan as substrate.",384,0.99999994,-0.09777981,-0.017262088,-0.11354806,-0.07896648,0.072976306,0.06297056,-0.042892206,0.037707917,0.017399766,0.02971568,-0.0008328168,-0.052530523,-0.064489976,0.10447003,-0.06620964,0.06796524,-0.06422771,-0.0026669155,-0.005235216,-0.036471277,-0.038196724,0.047908287,0.015709018,0.013566046,-0.028934067,0.019820692,0.055725534,-0.06553865,-0.025910154,-0.0761049,0.02341767,0.021931792,0.085036516,-0.032398533,0.035715267,0.0584827,0.012877943,-0.025947226,0.034136552,0.04611824,-0.0308828,0.003336154,-0.007554725,-0.060489062,-0.02893808,0.01859175,0.03311525,0.04521134,0.03262258,-0.037116755,-0.009893007,-0.054618765,-0.044539224,-0.007011818,0.054911684,0.07002538,-0.065730095,-0.05914194,-0.027009534,0.0017867342,-0.0066234716,0.008413507,0.019268809,0.00933892,-0.039084204,-0.07749648,-0.032000344,-0.11101146,0.00934392,-0.060458705,-0.00089823554,-0.09113521,-0.03703988,0.052746896,-0.004750523,0.044149127,0.01674806,-0.04297906,-0.008748276,-0.086622134,-0.0065932656,-0.02104267,0.04428993,0.06920913,0.024246275,-0.044982452,-0.007250133,0.018938458,0.055900943,0.042061,0.069520995,-0.02324922,-0.00089477113,-0.03729893,-0.06198481,0.047100194,0.05259601,-0.00660132,0.0025366105,-0.033684514,0.04086972,-0.036790416,-0.06250974,-0.051838044,-0.030904615,-0.08604688,0.029860582,0.07234839,-0.011089192,-0.056499586,0.010177417,0.017756937,0.064717,0.012596799,0.015326365,-0.013373184,0.0937554,-0.10615534,-0.016185885,0.034917716,0.04090119,0.044263937,0.039586306,0.11778484,-0.00035408826,0.07062683,-0.092691235,1.6299757e-33,0.059438914,-0.01824791,0.05403452,-0.021861061,-0.04850507,-0.030945344,-0.10902588,-0.018844388,-0.04921374,-0.11644478,-0.086254984,-0.02817439,0.045872327,-0.021486744,0.059580278,0.04047743,-0.10676609,0.024566036,0.045700025,0.0008981735,-0.015547569,0.06278281,-0.023434978,0.052796237,0.05875964,0.047914572,0.045786165,-0.0014114998,0.026194293,-0.013957639,-0.007870736,-0.059574056,-0.07122283,0.002500373,-0.052314214,0.07451987,-0.061391335,-0.026165916,-0.1342566,0.037602115,-0.056624793,0.055004593,-0.07315261,0.021349577,0.061474394,-0.06275156,0.0013596775,0.111564375,0.08260448,0.06370138,-0.020033043,0.005484654,0.034599308,-0.02135318,-0.031792138,0.08527431,0.008190565,-0.037977684,0.111144885,-0.010185034,-0.0075175734,0.04224092,-0.06455403,0.030523213,0.051679537,-0.018991876,0.0150800375,-0.08040774,-0.017812584,0.090409525,-0.048935235,-0.026180938,0.05385184,0.01048586,0.04866631,-0.07621126,-0.04150471,-0.032109387,-0.024193369,-0.017750865,0.11844666,-0.0025056682,0.078124516,-0.015737263,-0.0623894,0.016225196,-0.043217875,-0.043732345,-0.029713634,0.010787217,0.056719,-0.06883231,-0.019748094,0.006099454,-0.012077922,-2.24854e-33,0.05097658,-0.102939345,0.008307436,0.048037037,0.024268217,0.08398853,-0.032575194,-0.06371692,-0.022203583,-0.050572142,0.07037012,-0.05069619,0.08710953,-0.013450173,0.05383813,-0.004605666,-0.036354788,0.11159838,0.006056858,-0.02908003,-0.0023830244,-0.009685016,-0.0058471705,0.012706613,-0.013119896,0.05366604,-0.06986501,0.024971386,0.0020563554,0.024081983,-0.053910878,-0.0060254163,-0.053632617,-0.059673365,0.020986803,0.01375942,-0.10606394,0.064610794,0.0054676402,0.034532875,-0.06036566,0.049368672,0.06913853,-0.0303232,0.0062097847,0.060776368,0.0005109746,-0.00525567,0.04299933,-0.085310794,-0.032115992,-0.018067027,-0.038300324,-0.010371956,0.033949986,0.022503793,0.045564245,0.0961253,0.058861952,0.007422189,-0.02073316,-0.1035538,0.085898116,-0.009249809,0.013539802,0.030700369,0.008389722,0.098506436,0.027102647,0.035316702,0.04128018,0.0008512199,0.119436584,0.067650415,-0.027873103,-0.034823254,0.005342645,0.012096642,0.014352847,0.0658156,0.06144531,0.0056248605,0.019888531,0.0042997,-0.014472717,-0.091018945,0.028884051,0.026465092,-0.01725583,0.037989013,-0.022878928,0.021280877,-0.007240061,0.02260332,0.11098212,-4.090421e-08,0.046850756,-0.13934292,-0.01912411,-0.028676165,0.02882025,0.01471807,-0.01969422,-0.027327994,0.060831726,-0.09405884,0.052599564,0.041970108,0.060294285,0.033852387,0.052355923,0.036859196,-0.0114706205,-0.023976006,0.005702003,0.009926403,-0.111756995,0.037418976,-0.07775713,-0.042512666,-0.010257109,0.023981722,-0.0056274156,0.08265505,0.042957436,-0.035861015,-0.02299669,0.044865645,-0.004617045,-0.029459681,-0.01829185,0.04802243,-0.07012564,0.018557437,-0.0066782194,0.050360914,-0.003109883,-0.013038739,-0.08788089,0.02657395,0.002504817,-0.0034383498,0.004806671,-0.019179285,-0.092028,-0.015940348,0.063358344,-0.013393547,0.022373222,-0.0333162,-0.06817653,0.041090686,0.0026123452,-0.14886186,-0.05706063,-0.086895116,0.029398533,0.041546077,0.11468101,0.048539594 +1.14.20.4,"The enzyme requires iron(II) and ascorbate. It is involved in the pathway by which many flowering plants make anthocyanin flower pigments (glycosylated anthocyandins). The enzyme hydroxylates the C-3 carbon, followed by a trans diaxial elimination, forming a C-2,C-3 enol. The product loses a second water molecule to form anthocyanidins. When assayed in vitro, non-enzymic epimerization of the product can lead to formation of dihydroflavanols. Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin and (+)-epitaxifolin are formed. The enzyme can also oxidize the formed (+)-taxifolin to quercetin (cf. EC 1.14.20.6, flavonol synthase) [2,3].",384,1.0,-0.07128354,-0.031097578,-0.12439832,0.07282606,0.12881097,0.021912532,0.017567797,0.01007742,0.010926734,-0.04001192,-0.021761604,-0.013123186,-0.09931258,-0.019217407,-0.0911316,0.025782704,-0.07036981,0.07902654,-0.10034305,-0.03306612,0.044982344,-0.10691221,0.0071351486,0.027657535,0.018607559,-0.030464573,-0.009036553,-0.016857002,-0.041336775,-0.0547929,0.015468707,0.024137449,0.047586735,-0.04447114,-0.034923144,0.03646762,-0.039815534,-0.06348062,0.014501837,-0.03770691,0.010725896,-0.0044078315,-0.038099024,-0.052560166,0.004103726,-0.05651896,-0.03485208,0.01893359,0.016264284,0.06712168,-0.055576585,0.012088992,-0.055863775,-0.014530913,0.031331737,-0.0060868897,-0.024385354,0.046121184,-0.0121126175,0.07433755,0.0017608224,-0.028967489,-0.06573417,-0.0055301203,-0.03125454,-0.044040825,-0.053680316,-0.025073813,0.07880961,-0.024009762,-0.020559618,-0.0037591902,-0.0052322336,-0.008603422,-0.0036645825,0.16314211,-0.0010972099,0.05908969,-0.0036682256,-0.038961302,0.054740135,0.018992083,-0.016758965,0.09360173,0.038791202,0.015715446,-0.025391188,-0.0065447288,0.0039976705,0.12906359,0.11914992,0.069105305,-0.05463077,-0.010266867,-0.053553484,0.056037996,0.1323999,-0.04890778,-0.006247061,0.0058112647,-0.05400172,-0.010555927,0.06578181,-0.08163091,-0.039417315,-0.02115659,-0.01014867,-0.016541654,0.046869874,0.0054926104,-0.008192579,-0.03178479,-0.015124264,-0.017746117,-0.015950069,0.052269146,-0.020429896,-0.015178393,0.0010698264,0.010462215,-0.027942898,0.036294114,0.034670807,0.006509896,0.011169496,-0.015368217,-0.05889785,2.5902982e-33,0.06454975,0.040757928,-0.025746204,0.025650505,0.009469982,-0.0046146363,-0.034883644,0.06973476,-0.001734009,-0.06679528,-0.062005244,-0.069255434,0.010539704,-0.019045021,-0.029895889,-0.026996642,0.012639276,-0.13473402,0.06382115,0.042736575,0.09013497,-0.00993672,-0.15211567,-0.010042242,-0.037757564,0.03471264,-0.019005628,0.046422366,-0.008088004,0.023293324,0.044512898,-0.07812567,-0.028765805,0.025793979,0.082075074,-0.0038430914,-0.011157866,-0.034995276,-0.033166133,0.06627278,0.0028299084,-0.021321163,-0.010850021,-0.02498398,0.0056533515,-0.005167627,-0.042713027,0.07633833,0.061981473,0.07455218,0.03656541,-0.01775619,0.13448943,0.053974252,-0.06909784,0.021002417,-0.02722584,-0.079405986,0.053649746,0.025720775,0.013634371,0.013569823,-0.013497627,0.021057563,-0.0034507161,0.044322237,-0.13326429,0.00041267194,0.051724497,-0.024820372,-0.0069408445,-0.06326413,0.04615515,0.03035401,0.066924736,0.008181705,-0.082619235,0.07779113,0.04087299,0.044092484,-0.021135537,0.017302053,0.0090872515,0.03192597,-0.06654831,0.012125987,-0.0096952785,0.038346592,-0.037664488,-0.018431997,0.07782101,-0.078063115,0.03443093,-0.024454081,0.04903223,-3.8627042e-33,0.11121813,-0.038988136,0.025856629,-0.022400673,-0.029183978,0.060810525,0.042871952,-0.08714301,-0.015056216,-0.023169678,0.011054411,0.00091132097,0.068822466,-0.021834133,-0.027403222,-0.00022564796,-0.000931478,0.1099902,0.036672346,0.05454865,-0.072261155,0.05633461,-0.010937838,0.0042515714,0.050758228,-0.035149693,0.04011911,0.004298627,0.00017791022,0.08668483,0.0066997386,-0.0127255,-0.04061688,-0.03523765,0.01872787,0.03012822,-0.029983286,-0.02977606,-0.035117503,0.029990505,-0.058170356,-0.09403236,0.0040166867,0.064700894,0.08995647,0.053576708,-0.07259861,0.06267333,-0.007708793,0.033905614,0.0260603,0.044775203,-0.05660264,0.086318135,0.03373767,0.008676865,0.09190109,0.014644001,0.017175298,0.011995858,-0.052954935,-0.120731056,0.016095608,0.019436272,0.018603748,0.07673299,0.022070203,0.112755775,0.07038264,-0.08554403,0.08669704,-0.011061685,0.10498109,0.050034784,-0.048863593,-0.0048063155,0.02124763,-0.00084384216,-0.053038288,-0.032456808,0.0055609117,0.0068495977,-0.033276975,-0.048091833,-0.07523293,-0.09046118,0.04902352,-0.014581655,-0.10015669,0.0052101747,-0.015906712,0.0005714909,-0.067910224,0.09172286,0.096362755,-4.5173838e-08,-0.07874627,-0.07265705,0.030870214,-0.06520995,0.04947577,-0.0011838637,0.011746495,0.011125168,-0.026075644,-0.05277862,-0.022636443,0.07891563,-0.010003225,0.05139293,0.03580053,-0.019442245,0.0760024,0.04756036,-0.029538415,0.024355538,-0.11853361,-0.03706415,-0.1402134,-0.063110456,0.0042308317,-0.073745735,0.017670467,-0.013326166,0.042808738,-0.0013041616,0.02015979,0.033186648,0.024292342,0.00369026,-0.086258724,-0.016758857,-0.032232523,-0.07647951,-0.03974674,-0.037535407,-0.023500642,0.023437148,0.0013258569,-0.018471714,0.017253963,-0.05867176,0.01624479,0.04769149,-0.02796518,0.04357062,0.06582709,0.0035690574,0.019671837,-0.08475687,-0.022512006,-0.016069194,0.053423814,0.0063518477,-0.025901098,0.032777373,-0.07745893,0.011652108,0.13756576,-0.018280186 +1.14.20.5,"The enzyme, which has been found in rice and in members of the Apiaceae (a plant family), is a member of the 2-oxoglutarate-dependent dioxygenases, and requires ascorbate and Fe2+ for full activity.",384,1.0,-0.057688918,-0.032855093,-0.06559953,0.08932547,0.083842225,0.039537143,-0.07621862,-0.028325202,-0.0023746265,-0.030764256,0.1110548,-0.033553388,-0.048635583,-0.007356595,-0.043898385,0.0493068,-0.038760446,0.00018112724,-0.031759106,-0.08303746,0.062448148,0.059067037,0.018217253,-0.050205234,0.059905663,-0.03453627,0.0014524284,-0.049418595,-0.019287243,-0.10048744,-0.025966838,-0.0056979777,0.059821192,0.02034794,-0.010321671,0.09894745,0.00918801,-0.108061366,0.08802654,-0.03231615,-0.049882468,-0.01806091,-0.011423485,-0.04963064,-0.05298208,-0.049304653,0.055440262,-0.07113483,0.0408147,0.022230944,-0.04147779,0.0133542875,-0.018491646,0.004070012,0.021056503,-0.026578426,0.023447836,0.031139975,-0.12877335,0.04406123,0.027209213,0.0046667918,-0.010813441,0.03681283,-0.060318917,0.0036476231,-0.019866807,-0.022541465,0.023343237,-0.112298794,-0.016656756,-0.09433484,0.03289594,0.009707523,-0.053530637,0.035863105,0.045234457,-0.024285465,0.06316813,-0.044543646,0.041762795,0.015183765,0.092938505,0.05017092,-0.0048060236,0.05291556,-0.06831569,0.0019589574,0.010126647,-0.0037934904,0.05356504,0.011908234,-0.036937017,0.008346888,0.08731776,0.037649788,0.06554818,-0.00308188,-0.010551969,-0.014608263,-0.024378069,0.08481824,-0.032362297,-0.052337863,-0.025748467,0.018248895,-0.08662432,0.01304362,0.022568751,-0.028929064,0.07410782,0.047019593,0.02754091,0.035036694,0.022788037,0.040382832,0.04358362,-0.09530981,-0.07053588,-0.023557892,0.02430642,-0.03445321,-0.01065378,0.051507656,-0.027354214,0.023683105,-0.09380593,-1.8492513e-33,0.058376342,0.062290687,-0.014608814,-0.025819222,-0.012095804,-0.017610556,-0.0012743811,0.007471984,-0.050255205,-0.044192344,-0.13292548,-0.057456892,0.01659979,-0.017967487,-0.0077867997,-0.032003112,-0.034024257,-0.043169837,0.059073012,0.010498368,-0.0024197386,0.05224887,-0.065147385,-0.028456772,-0.0243045,0.060431633,0.0098710125,-0.03670457,0.025415648,-0.020964341,0.04832279,-0.089897126,-0.09397863,0.031574167,0.019352885,-0.036902614,-0.044311363,0.0047682975,-0.06497963,0.057812374,-0.0032139195,0.12967318,0.009094644,-0.0649162,0.055104088,-0.053462695,-0.015011782,0.10494928,0.024112765,0.08791494,-0.01750997,0.06610047,0.09613312,0.0049258345,0.022720527,0.029711382,0.01032283,-0.017473642,0.06943815,0.124479875,-0.011701652,-0.035412524,-0.03781286,0.08884904,-0.01569994,0.046911746,-0.08754513,-0.0070457365,0.006558262,0.16518654,-0.024319747,-0.04396241,-0.0051830253,-0.006114895,0.007817746,-0.059083693,-0.034985032,0.016877618,0.0049678306,0.007821796,0.051431954,-0.0039914735,0.024506398,-0.00032568732,-0.05120373,0.03094407,-0.064958796,-0.033670887,-0.0026629062,0.040817503,0.061323006,-0.0030751333,-0.069680974,-0.06011003,0.06295615,-5.976554e-34,0.09105364,-0.08368831,0.030244406,-0.087803826,-0.058533024,0.06509468,0.03209091,-0.03381211,0.04346539,0.08850218,0.042035677,0.029594831,0.042585615,-0.08785833,0.06717221,0.031903565,-0.051448483,0.101736344,0.01806311,0.085071154,-0.016553368,0.12065574,-0.00042862052,-0.020062119,0.071647786,-0.022020813,-0.07004892,0.03413799,0.0013630873,-0.020507192,-0.012795064,-0.0577187,-0.032231662,-0.025919035,0.019870145,-0.0071772495,-0.08104988,-0.024532728,0.00043945012,0.06403851,-0.022088354,0.042689074,0.022523671,0.10344209,-0.0019621488,0.014872741,-0.16950844,0.05590865,-0.019150907,-0.043989483,-0.045435198,-0.037641723,-0.023532422,-0.014355597,0.013076977,0.028535698,0.022765657,0.05399932,-0.060217917,0.022821661,-0.010267049,-0.0464133,0.042384014,0.018310802,0.0062740534,0.027341908,-0.019685868,0.03594419,0.018689321,0.06014152,0.0020525095,-0.029823774,0.012095389,0.02900334,-0.028041352,-0.008855792,-0.07885218,0.014146211,0.0107494835,0.025741762,-0.00799566,0.0051969686,0.03718073,-0.054907355,0.0007138135,-0.07449075,0.009706878,0.13088118,0.032195456,0.02987857,-0.019835237,-0.06481569,-0.06998763,0.024065066,0.079473585,-3.6778268e-08,-0.049365796,-0.089155674,0.08087707,-0.031225411,-0.049394414,0.003418587,0.05430574,0.023424195,0.012437854,-0.0056843623,0.00759821,0.11174253,0.0040971683,-0.017009076,-0.0055754324,-0.03370663,0.024387296,0.08777298,-0.029772477,0.023780521,-0.044827905,-0.009955575,-0.1081033,0.015790028,0.014503177,-0.015156077,-0.021591946,-0.00214831,0.043353517,-0.024010235,-0.03301904,0.0052257376,0.0101159895,-0.107738815,-0.10401833,-0.028927451,0.0127745485,-0.049516834,-0.053444393,-0.0099468175,0.013658021,-0.065117285,0.0033530917,-0.0019313786,0.00030877913,0.039802767,0.024803778,-0.019707851,0.030299913,0.06237579,0.028175548,-0.03789097,-0.017569596,-0.06182732,-0.087843314,0.046797607,-0.008195783,-0.05062715,-0.003965868,-0.06574055,0.0032614837,0.051810097,0.19468577,-0.048229247 +1.14.20.6,"In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from Citrus unshiu (satsuma mandarin) also has a non-specific activity that trans-hydroxylates the flavanones (2S)-naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively [2]. Requires Fe2+.",384,1.0,-0.0433158,-0.09352823,-0.093549974,0.098063625,0.044355087,0.09434979,-0.10976802,-0.01296551,0.0063565606,-0.12592025,-0.011483614,-0.07271572,-0.09391052,-0.055871148,-0.037355796,0.040571526,-0.0458419,0.07938262,-0.09037244,-0.03855043,0.03314706,-0.082915545,0.0119287465,-0.040511847,-0.005967517,-0.025611807,0.024503443,-0.064851895,0.023762686,-0.111740194,0.089571625,0.03552405,-0.024150183,0.01784635,-0.053552773,0.0042251856,-0.026431417,-0.09273323,0.014601406,-0.011884716,0.06255157,0.00497062,-0.038802307,-0.044964895,0.045942858,-0.066765726,-0.08066956,-0.0072639016,0.06816428,0.04430083,-0.06705497,0.021432461,-0.010903357,0.08815585,0.02725432,0.039942246,0.06495343,0.013626027,-0.028381377,0.077219896,0.054978985,-0.049481794,0.0010705498,-0.0056690527,-0.06950887,0.029450582,-0.062834084,0.0092040505,0.039692342,0.042099107,-0.044533677,-0.011880131,-0.0056867003,0.01965053,-0.018237617,0.054297946,0.014843092,0.051735815,-0.023229407,-0.034152802,0.05560319,0.004985367,0.03423787,0.043369085,0.037585642,0.018519873,-0.14389148,-0.012073704,0.014225659,0.16881551,-0.011900103,0.084945306,0.003066713,-0.043243922,-0.0027880506,0.04638725,0.011908371,-0.00037402348,-0.041859254,-0.018971201,-0.0073510087,0.05898651,0.019082297,-0.08508965,-0.09091853,-0.0077379514,-0.058187738,-0.049443338,0.008924229,0.039693467,0.07764175,-0.039460856,0.036450066,-0.07186671,-0.07384091,0.041119583,0.01635337,-0.02909214,-0.012938574,-0.0207964,0.018062722,-0.04110807,0.009838488,-0.0013370013,-0.035683658,-0.014889732,-0.03345321,4.249152e-33,0.033771288,0.017891923,-0.06251129,0.063193515,0.052100968,-0.068480775,-0.08291399,0.021294469,0.046957977,-0.05485159,-0.11045963,0.032042447,-0.054782636,-0.01543153,0.035409234,-0.057384744,0.053712342,-0.082310565,0.08274514,-0.09307232,0.07433288,0.0006662441,-0.07115332,-0.030579882,-0.061354544,0.012800468,-0.005946278,-0.010457862,0.034613367,-0.02653605,0.021952627,-0.096788004,0.0013418804,0.06465318,0.017465806,-0.012425067,-0.047525264,-0.032145295,-0.025930323,0.09312758,0.03995432,-0.010892598,0.029673638,0.03176379,0.0352808,-0.064375155,-0.070760176,0.033855174,0.048901938,0.017514521,0.002924689,-0.008172183,0.08596289,0.042792518,0.005145669,-0.0010651256,0.01356135,-0.022025358,0.024216086,0.050818518,-0.066541806,0.0062354435,0.021382844,0.04352413,-0.06281863,0.04094035,-0.06960375,0.0049890783,-0.01993179,0.01562691,-0.004777887,0.0056775697,0.10819029,0.029766092,0.08723892,-0.012130017,-0.052335326,-0.027020719,0.06830307,0.057456207,0.009157941,0.03719842,0.0088319965,0.11486651,-0.07729078,-0.035454866,-0.06706179,0.02708588,0.0643024,0.012278561,0.0332014,-0.05895401,-0.018342678,0.013201319,0.0665803,-4.941269e-33,0.014871719,-0.077871226,0.026071372,0.0088314945,0.0064575425,0.045916162,0.011380889,-0.06526457,-0.00076777634,0.028913643,0.062253695,-0.032015964,0.017638791,-0.052194048,0.026874404,0.045094613,0.07218082,0.13931192,-0.082253315,-0.02121655,-0.0052467217,0.06552019,-0.01577888,0.027009437,0.035188444,0.0040872046,0.056702796,-0.015704118,0.0058050603,0.11612841,0.06804355,-0.005827853,-0.051636495,-0.046761688,-0.0068909014,0.021941433,0.008040041,-0.014924106,-0.050017703,0.059914105,0.008041817,-0.0064226277,-0.0074830474,0.050704055,0.053980336,0.06478015,-0.10053041,-0.044461995,-0.012027488,-0.0011428983,0.038516935,0.044247594,-0.063637964,0.08575,0.016184215,0.006169109,0.066532895,-0.016439619,-0.001694597,-0.0056411712,-0.0222471,-0.109705925,0.026778584,-0.06822456,0.02063373,0.04667966,0.06212272,0.12811287,-0.003823554,-0.026984962,0.054281686,-0.046668023,0.044204347,0.103636555,-0.030611193,-0.027600998,-0.0116231525,0.023278013,-0.027566794,-0.016008595,0.005685739,-0.063042656,-0.0009898517,-0.07966045,-0.011349506,-0.07029621,-0.0010986393,0.0058166757,-0.0017806957,-0.008323281,-0.0021987245,0.017980678,-0.10349919,0.02720206,0.0063368906,-4.4804388e-08,-0.005762846,-0.11852332,0.008424533,0.015159863,0.025698286,-0.011917633,-0.06325007,0.023504516,-0.044339623,-0.028479185,-0.07339932,0.041055016,0.004430969,0.010473517,0.037628636,0.0054370146,0.10634772,0.0901511,0.0053873854,0.027563548,-0.06695158,0.07759983,-0.08762642,-0.07485994,-0.008897495,-0.04698614,-0.076209925,-0.0029589224,0.13538769,0.007869252,0.036504634,0.027010297,0.0022360275,0.008546123,-0.1260173,-0.0036387234,0.06594875,-0.044910677,-0.06311794,0.030429129,-0.047755405,0.031797267,-0.0333654,0.06324053,-0.046039376,-0.06265019,0.003423755,0.033951964,0.030341407,0.010726087,0.034127705,-0.031498678,0.018601522,-0.015575931,-0.0378831,-0.026703708,0.0053520873,-0.018553194,-0.025199832,-0.01804784,-0.02141857,0.0066264905,0.09321194,0.017801788 +1.14.20.7,"This is one of two simultaneous reactions catalysed by the enzyme, which is responsible for ethene (ethylene) production in bacteria of the Pseudomonas syringae group. In the other reaction [EC 1.13.12.19, 2-oxoglutarate dioxygenase (ethene-forming)] the enzyme catalyses the dioxygenation of 2-oxoglutarate forming ethene and three molecules of carbon dioxide.The enzyme catalyses two cycles of the ethene-forming reaction for each cycle of the succinate-forming reaction, so that the stoichiometry of the products ethene and succinate is 2:1. The product of the enzyme, L-glutamate 5-semialdehyde, exists in equilibrium with the cyclic form (S)-1-pyrroline-5-carboxylate.",384,0.9999999,-0.067308724,-0.02880256,-0.012221599,0.006871395,0.09050054,0.030669224,-0.067407824,0.0458943,0.01054762,0.04175123,0.03465897,-0.10702793,0.010218413,-0.035164464,-0.062340748,0.013316631,-0.12838139,-0.031469062,-0.04598646,-0.046114426,0.13151045,-0.00027098288,-0.04438884,-0.010995306,0.092494115,0.05126738,0.05015671,-0.028602472,-0.066010825,-0.062032845,0.010326116,-0.07666434,-0.053084623,-0.032498017,0.024276253,0.0002076219,-0.03577146,-0.023435485,0.07877443,-0.035013866,-0.008127561,-0.030778138,-0.053371247,-0.054633055,-0.019644909,-0.004045226,0.016518688,0.018327748,0.0054414533,-0.09941846,0.0015473107,-0.065529265,-0.04508821,-0.005454942,0.020654332,0.00075499463,0.0054698116,-0.01102627,-0.053710416,0.0033191007,0.04443283,-0.04202506,-0.08891346,0.032927535,-0.010598429,-0.041752677,0.053155784,-0.06879401,-0.038789414,-0.025537357,-0.0645333,-0.04196007,0.04897701,0.012431403,0.07110552,-0.00961482,0.039132413,-0.057217643,0.012412338,0.0018864132,0.055222742,0.027349409,0.029404253,-2.7071907e-05,-0.0030787524,-0.0364373,0.06734084,0.007636127,0.06140366,0.04227061,0.0073344796,0.035030562,-0.021335587,-0.020590108,-0.02669125,0.07793568,0.0038584308,0.11620148,0.073553,-0.039747663,-0.02380552,0.047755938,-0.015290702,-0.14322515,-0.03065017,-0.023233498,0.011251741,0.022990702,0.014800355,0.0008219712,0.041754577,-0.01912551,0.020421999,0.04648407,-0.028718963,0.16434151,0.09016314,-0.071919404,-0.056701384,-0.054677732,0.03219761,-0.019358506,0.06456267,0.05708035,-0.0658535,0.010650466,-0.07580174,4.064518e-33,0.0160972,-0.02252079,-0.03230829,0.029699307,0.051914413,0.033315413,-0.11375323,0.06924997,-0.034808468,-0.024976375,-0.106683135,-0.056057516,0.061697505,-0.042638022,-0.03520304,-0.036429185,0.0053538475,0.015911462,0.033936225,-0.022911195,-0.0044254535,-0.0021386982,-0.025125382,0.029045573,0.023541087,0.037946407,0.07432201,0.0015119127,-0.021100855,-0.02421386,0.06098902,-0.061265003,-0.076201215,0.003348695,0.069280095,-0.033998962,-0.010136067,0.05729961,0.055689365,0.08898564,0.032265477,0.091738716,0.026426893,-0.043683954,0.051738,-0.07161401,-0.05552565,0.12162146,0.036290392,0.12469025,0.020583529,0.00748262,0.10491273,0.040638283,-0.0063238638,0.06947642,-0.02755787,-0.03126374,0.056627456,0.038819518,0.029512618,0.09852905,-0.03186909,-0.050263256,-0.009790915,0.09973,-0.048783533,-0.014883026,0.008089345,0.059538428,-0.058372363,-0.04419751,0.056971665,-0.0029738403,0.05709687,-0.04271482,-0.0377553,0.07384804,-0.00602849,0.03018828,-0.0445965,0.02604647,-0.012394885,-0.03372494,-0.041431777,-0.04657937,-0.055538815,0.012138604,-0.028562194,0.09601904,0.083103426,-0.06562877,-0.015531665,0.00096847705,0.03346338,-4.466204e-33,0.13104339,-0.094410576,0.004289946,-0.09527502,0.0061293333,0.014163113,-0.01953361,-0.024256157,-0.004261809,0.0040683714,0.0777081,0.0376067,0.09240396,0.035230994,0.023007318,-0.0608318,0.017861208,0.052659746,-0.008291568,0.007641336,0.093506075,0.04790041,-0.012322153,0.0022792416,0.09485828,-0.013725086,0.013878695,0.051371086,0.044325944,0.025353545,-0.03787132,-0.04446881,0.025468491,-0.0004005087,-0.044059616,0.042660013,-0.018282285,-0.025206244,0.022413073,0.07636707,-0.05461151,0.049051356,-0.022014389,0.06594272,0.0151955355,0.006673441,-0.08915102,-0.02799422,-0.020647014,-0.065560445,0.030614354,-0.015384196,-0.07275747,-0.055779494,-0.004176649,0.032358326,-0.021697817,-0.009436983,-0.027459316,-0.042155534,0.009609521,-0.07455259,0.0027856815,-0.044525515,0.025618624,0.017798895,-0.10125118,0.033793442,-0.02072258,-0.0011184076,0.048519604,-0.031793047,-0.06208661,-0.030325448,-0.07557689,-0.035347875,-0.010527086,-0.04470929,0.026038798,-0.033571366,0.013456963,-0.019641913,0.018458046,-0.0065713264,-0.10372967,-0.09016223,0.059226055,0.07746628,-0.046280906,0.026048232,-0.044249006,0.034550574,0.008368345,0.16240123,0.11427801,-4.533378e-08,-0.014323953,-0.08078689,0.0914821,0.06675623,0.014781551,0.02552538,0.02265116,0.00013410402,0.041665953,-0.057055507,-0.03975995,0.10900486,0.017286548,0.007572564,0.029130118,0.031173589,-0.093845405,0.0109821595,-0.028285034,-0.004242496,-0.009536904,-0.043360185,-0.12261041,0.03804801,0.009663916,-0.04333901,0.060323533,0.023270948,-0.044557095,-0.078709856,-0.04029954,0.007383937,0.027570821,-0.057813153,-0.051183734,-0.010965981,-0.07852932,-0.007988127,-0.023365263,-0.031109208,0.03132977,-0.006133472,-0.030407105,0.023007939,-0.007221113,0.033164147,0.026105164,-0.019452766,-0.00060127495,-0.025889864,0.058104903,-0.022670317,0.03178585,0.004012585,-0.07362441,0.02656219,-0.05587646,-0.021508118,0.03628681,0.04675269,-0.0071143806,0.072291575,0.13925903,0.021729253 +1.14.20.8,"The enzyme, characterized from the plant Sinopodophyllum hexandrum (mayapple), is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.",384,1.0,-0.014802043,-0.015446076,-0.09568329,0.0408169,0.019539304,0.08543185,-0.025970574,-0.03193901,0.066861175,0.007843989,0.026823051,-0.031647917,-0.06950238,-0.016383132,-0.1057303,0.057137344,-0.15756108,-0.01669983,-0.0008311879,0.015080073,0.0019937428,0.05626367,-0.010341041,0.037001245,0.046826262,-0.053544067,-0.096132435,-0.006135307,0.0032428084,-0.049727835,0.0115877995,0.083872676,0.033257987,-0.03359311,0.06775161,0.100717254,-0.025524762,-0.034614697,-0.0015082713,0.01971386,0.038264025,-0.03139379,-0.025506053,0.0008552825,-0.06520055,-0.036454897,-0.043948345,-0.03525117,0.04016038,0.033262752,-0.04758415,-0.108330324,-0.062672175,0.006554708,0.049508844,0.0002070131,0.029766314,0.0059987726,0.02544087,-0.024029719,0.10334835,0.023244034,-0.012968259,0.049004268,-0.016890345,-0.09185164,-0.03348144,-0.028796006,0.022255715,-0.013567271,0.006715766,-0.08578225,0.049708314,0.03569413,-0.019260209,0.009884547,-0.015273163,-0.033811748,-0.01919739,0.0067236447,0.063413054,0.082381494,0.12000033,0.12243678,-0.0013082322,0.06493573,0.00252281,0.02053256,-0.008949469,-0.04785128,0.055913374,-1.4381615e-05,-0.04710186,-0.027276307,-0.028868204,0.038401537,0.07700089,-0.031277835,-0.011348483,-0.005852168,0.08823312,-0.01834891,-0.09234029,-0.1408433,0.043515153,0.02172309,-0.05190031,-0.0049016066,0.0189729,-0.016763553,-0.047175296,-0.038289655,0.0019548147,0.015690204,-0.03905959,0.07823442,0.025426736,-0.0073076375,-0.041264277,0.047953334,-0.029292345,-0.0010550374,0.031017251,0.057538785,-0.06694908,-0.02306649,-0.06354391,2.7916195e-33,0.08509471,0.052960813,0.013977929,-0.047636915,0.068621814,-0.08267154,-0.067438796,-0.07386559,-0.0935744,-0.013787109,-0.12284508,-0.032269437,-0.0024594804,0.043198794,0.0122135235,0.0042056926,-0.106998436,-0.01905125,0.03489805,-0.069151305,0.0008115402,0.009493133,-0.14255075,0.015680423,0.0074026943,0.123657174,0.03464659,-0.0015527727,0.030758355,-0.008827649,0.009618514,-0.012005226,-0.08177322,0.018330034,-0.0030008992,0.010821646,0.01403049,-0.025105732,-0.06724591,0.056564778,0.06836961,0.03042674,0.021023853,-0.041490916,0.088606924,-0.01056068,-0.052019823,0.06790648,0.06607068,0.04715004,0.009810339,-0.0142054325,0.088380046,0.033759266,-0.07187089,0.03315441,-0.03114737,-0.0078015253,0.013559902,0.044313565,0.0023544815,-0.086689085,-0.016092958,0.029218715,0.0087219495,0.078227684,-0.04022781,-0.095843844,-0.00096171733,0.033768613,-0.104025,0.012240096,0.04724103,0.08759788,0.030475609,-0.009322708,-0.022495005,0.046069264,-0.05362384,0.036350016,-0.023065696,-0.01539705,0.008135811,-0.012438317,-0.011523116,-0.05156734,-0.018658921,0.03716977,-0.038413394,0.038044687,0.010660862,-0.06267709,-0.09872168,0.0028684882,-0.0518278,-4.1087616e-33,0.046345804,-0.09632063,0.06897663,-0.053513695,-0.028796077,0.07369541,-0.044346288,0.0022323423,0.045181945,0.03234761,0.059504274,0.019920602,0.08048946,0.015944323,-0.0104842,-0.006125623,0.026804898,0.020401275,-0.011573959,-0.01680801,-0.060740415,-0.01668489,-0.07960366,0.015681718,-0.006296458,0.01783232,0.023735523,-0.047776412,0.00026354752,0.059242327,0.0058874465,-0.04472977,-0.12160289,0.028140727,-0.020364087,0.032988172,-0.10156481,0.008299417,0.0032790236,0.020854672,0.04454064,-0.015146594,0.0069393464,0.027706305,0.08829496,0.024561923,-0.07040093,0.080323815,-0.0063777617,-0.05002798,0.020332225,0.018053802,0.051903132,0.053664256,0.03477246,0.042317715,0.031652957,-0.011455288,0.0050734594,-0.01477927,0.02205183,0.020802174,0.023352614,0.035128515,-0.0077021853,0.10925051,-0.024831034,0.037316494,-0.0014461728,-0.031413015,0.07827981,0.026336601,0.03510876,0.09460397,-0.05057018,-0.014404825,-0.020535642,-0.08741478,-0.008240416,0.013236082,0.057294115,0.03214968,0.033751454,-0.048494373,0.0008819899,0.012676152,0.06541335,0.11360819,0.0067952294,-0.009947449,0.036795918,0.038545165,-0.083646245,0.007155383,0.05802487,-4.0507413e-08,0.05207179,-0.03025246,0.03678908,-0.09149619,-0.08421331,0.012876762,0.06215814,0.015220163,0.044554062,-0.05260814,-0.0017696696,0.03629215,-0.01657192,0.014702721,-0.012234361,0.021274986,0.026349587,0.055946812,-0.006737217,-0.033613667,-0.065064095,0.010798796,-0.0105386665,0.001919339,-0.020114906,-0.033736024,0.030375693,0.07112242,-0.0086658755,-0.06698213,0.008447293,0.05398999,-0.08764647,-0.002847783,-0.13067982,0.09711306,0.004102417,-0.10352488,0.011163657,0.015071186,0.0328118,-0.04981403,-0.021172646,-0.049475037,-0.05198853,-0.015679428,0.066286735,-0.016777078,0.05280144,0.032986246,-0.010954317,-0.0073192213,-0.0016188592,-0.092102975,-0.09704637,0.017429883,0.009543364,-0.02792915,-0.017002888,-0.052896846,-0.06629472,-0.06715812,0.21213491,0.034652635 +2.1.1.348,"This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.",384,1.0,-0.040360365,-0.022225665,-0.14582832,-4.804717e-05,-0.0040308386,0.041337263,-0.04809134,-0.014258066,0.07134899,0.004168545,0.05266643,-0.03365353,-0.013198123,0.013174087,-0.0060156514,0.11489005,-0.115949,-0.059806347,0.0069309385,-0.070233606,0.047376033,0.122441225,-0.0259312,0.025894685,-0.019611971,0.052225295,0.07314593,-0.022366408,-0.0016287529,-0.042588037,0.004579732,-0.03497806,0.06077809,0.049197897,0.050839145,0.1360467,-0.069630705,-0.07972186,0.028165534,0.026604487,0.046248548,0.02258547,-0.025125457,-0.031236136,-0.058937464,0.006180665,0.0069865375,0.0058024535,0.07258525,-0.014825218,-0.00746572,-0.13520561,-0.020227548,0.0073560453,0.10142434,0.062293436,-0.057123587,-0.05555053,0.019418985,-0.012033427,0.10838929,-0.033799637,-0.03929482,-0.0051543666,0.080400646,-0.061359476,0.060233884,-0.028693426,-0.0074535864,-0.07049027,-0.07495527,-0.05482776,-0.015487826,0.070690855,-0.04406218,0.013837728,0.018665181,-0.06978168,0.022862596,-0.026442267,-0.01951331,0.030541673,0.04253086,-0.024314648,0.051084425,0.02729202,0.05550766,0.041151717,0.041306295,0.010559731,-0.0048713554,0.0008022808,0.0321971,-0.020168984,-0.017037686,0.00088393595,0.0876537,0.04305367,0.04165573,-0.02222527,0.042689726,0.07728462,-0.092937164,-0.030816473,-0.05371811,0.013813355,-0.000750013,0.07163067,-0.023003053,0.01088959,-0.040602285,0.06569276,0.011633799,-0.01859571,0.019921549,0.016490316,0.03963153,-0.025974406,-0.0050588413,0.0029022861,-0.05639687,-0.029386211,0.030745812,0.041015953,-0.011035477,0.0037331167,-0.12638237,-1.8499936e-33,0.08372464,0.023332056,0.01593958,-0.0376712,0.036344714,0.031317603,-0.05150662,0.025233515,-0.00375714,-0.10488015,-0.06474084,-0.09109487,0.022936907,-0.02288904,-0.04452458,-0.027826104,-0.054579187,0.025511935,-0.0070711817,-0.046117567,-0.05994948,0.0038288666,-0.022198286,-0.053091,-0.090261385,0.015027962,0.02534043,-0.052721426,0.095159136,-0.016403375,-0.06731397,-0.060950242,-0.09344518,0.037322666,0.029951025,0.04403486,-0.012948822,-0.01978474,0.021040626,0.113878556,0.024486048,-0.03867537,0.0036743456,-0.06189761,0.036442563,-0.025037568,-0.09248311,0.052535173,0.017518178,0.025758196,0.03784223,-0.01644373,0.036710866,-0.0715635,-0.10076518,-0.018720489,-0.036529236,0.0077998084,-0.008935892,0.077761464,-0.0029011278,0.013368855,-0.009489427,0.047234025,0.005658504,-0.020342518,-0.12059301,-0.105823874,0.032764792,0.12456159,0.016412795,-0.007216728,0.13974044,0.006752878,0.025507864,-0.011576365,-0.0731098,0.023683967,-0.007212738,0.06720832,-0.033170152,-0.024630586,0.009876117,-0.01942324,-0.019672321,-0.044009503,0.043845546,-0.08185281,-0.043559127,0.06586083,0.029311564,-0.032110438,-0.054747526,-0.026769208,0.045169294,-7.928421e-34,0.10850866,-0.02734734,0.07019364,-0.04427473,-0.0004250825,0.013241643,-0.01883923,-0.04756526,-0.025612552,-0.07387161,0.09324658,0.036689077,0.061728325,-0.025527116,0.08030106,0.0072394107,-0.0067090346,0.072378464,0.018321391,0.017789708,0.019591166,0.0039004004,-0.0077155307,0.06609435,0.03837091,-0.017395783,-0.037969135,0.066729866,0.09558786,0.008251854,-0.03699564,0.012331187,-0.042541906,-0.044884663,-0.0072654923,0.07467656,-0.026376855,-0.028821122,-0.00232522,0.052092507,-0.030637316,0.04684306,-0.06719714,0.07751309,-0.010960327,0.052033946,-0.0046124253,0.032701053,-0.025432784,-0.06782058,0.054570373,-0.010295476,0.021062132,0.008351397,0.030657213,0.015308241,-0.039129604,0.06823544,0.030864168,-0.022261076,-0.06168998,-0.024319671,-0.025833074,-0.026352463,0.046045866,-0.007881812,-0.038419914,-0.011089597,0.025612196,-0.009187916,0.096298,-0.014085339,-0.01231827,0.00770671,-0.036276337,-0.07862361,-0.046150148,-0.053172503,-0.047507256,-0.02445494,-0.025359228,0.028986428,0.017979298,-0.052242164,-0.0043963185,-0.043871548,0.06732557,0.07273702,-0.0759318,0.04138345,-0.021260608,-0.015251017,-0.048754707,0.08453866,0.06361879,-2.2927871e-08,0.0025994077,-0.1200589,-0.008434368,-0.09111941,0.08315235,0.09606603,-0.0054549295,0.044173665,0.0530282,-0.021745672,0.022760909,-0.0219199,-0.014421016,0.068438284,0.015477133,0.067895554,-0.061641213,0.0018307061,0.02612521,-0.017976614,-0.12676921,0.017581435,-0.05621277,0.0066189473,-0.025700327,0.029056478,0.056606144,0.1254986,-0.003275882,-0.04666944,0.014031726,0.024527116,0.036618914,-0.07453341,-0.0706747,0.045264896,0.0725324,0.01070472,-0.027854787,0.001629048,0.041748542,0.018284995,-0.04798185,0.0017683068,-0.019852905,-0.0031409012,-0.051708456,0.04002701,-0.0112639675,-0.097473085,0.029016627,0.014595754,0.031238351,-0.02052708,-0.047080103,-0.0053144232,-0.068567954,-0.09525871,-0.017619161,-0.0073389183,0.016926043,0.021697888,0.18642503,-0.06539932 +2.4.1.353,"The enzyme, isolated from the fungus Sordaria araneosa, is involved in the biosynthesis of the glycoside antibiotic sordarin.",384,0.99999994,-0.043767426,0.00085889676,-0.19151956,0.02327745,0.05923458,0.045121953,-0.13784514,-0.0031091855,0.057189737,-0.08826704,0.047134504,0.0048391325,-0.07917363,0.015221607,-0.09181351,-0.027440855,-0.0045323214,0.030196028,-0.03475213,-0.006301323,0.04716352,0.0318474,0.056811474,0.04562319,0.022108551,-0.021246633,0.037286222,-0.030800302,-0.042857762,-0.07147075,0.051244657,0.010130515,0.022631885,-0.05960044,-0.013656085,0.07680799,-0.030721094,-0.010855619,0.098386556,0.03399857,-0.077504076,-0.07256357,-0.045655385,-0.048424408,-0.060502872,-0.03293295,-0.042758767,0.026000837,0.06825515,0.0053850976,-0.014085832,0.0074411537,-0.09117754,-0.046953704,0.054762807,0.055267137,-0.03173266,-0.03518811,-0.015445729,0.03599352,0.09175405,0.042762898,0.012243514,0.060688045,-0.08464852,0.0061830105,0.027667396,-0.039496556,-0.018407723,-0.02126558,-0.07153467,-0.080966055,0.013001373,0.069373235,-0.021953203,0.030195197,-0.00019088713,0.030248662,0.062763065,-0.018020866,0.07727589,-0.03392667,0.013894632,0.11811271,-0.030905513,-0.022046108,0.06850436,0.035679612,0.0424707,0.04208069,0.13255125,0.009139968,0.0013097944,-0.07998566,-0.02290934,-0.00020411686,0.021620033,0.011025681,0.0064970427,-0.043340374,0.01496053,-0.024379559,0.026766919,-0.0561254,-0.0035754596,0.012260863,0.006310999,0.027842319,0.12447074,-0.0053506396,-0.029885227,-0.008563228,-0.036066793,-0.06879936,-0.04614613,0.03176353,0.08481104,-0.028116101,-0.08269766,-0.020688664,0.04191657,-0.0070809866,0.005994946,0.08906149,0.013199685,0.021807207,-0.03500288,-6.193762e-34,0.06030832,0.016708752,0.003253776,-0.088295855,0.030074555,-0.054006964,0.014023504,-0.012795081,-0.05010915,-0.05805684,-0.051339924,-0.097542845,-0.057512343,0.073648214,0.057349067,0.028533148,-0.030525133,-0.08330927,0.05602233,0.0217284,0.04436587,0.056474958,-0.035920717,0.00023639429,0.07146942,0.08995435,-0.063811116,0.05752695,0.06887405,-0.013828645,0.06065248,-0.10668882,-0.09746296,0.02462317,0.062958114,0.014756686,-0.010218842,-0.0321563,0.026992457,0.016251864,0.008788352,-0.0069024153,-0.005401526,-0.014597383,0.02547086,-0.0010682852,-0.05462682,0.087311484,0.038056627,0.016505728,0.016073236,-0.04129723,0.04003129,0.055521853,-0.033589263,0.035901804,-0.022070896,0.054764435,-0.01989338,0.08533646,0.022937393,0.05066245,0.029456316,0.09892463,0.034368448,-0.010119705,-0.029305466,0.00980556,0.007628412,-0.057692237,-0.046123166,-0.015708696,0.023069695,0.0153374225,-0.04443202,0.014879547,-0.03294616,-0.021919915,0.014173134,-0.013318088,-0.058552857,0.0067329616,0.05092468,-0.03675168,-0.02076489,0.09404105,-0.035356518,-0.055998344,-0.07447021,0.0714942,-0.0029515817,-0.09230347,-0.03389901,0.0128834145,-0.0026324817,-2.9383134e-33,0.09770099,-0.1037164,0.066393,-0.08331591,-0.0559139,0.13820548,0.00839166,-0.03364359,-0.062087804,0.016721755,-0.014879965,-0.018888636,-0.0041968212,-0.06611894,0.014828437,-0.026815835,0.03132206,0.08602866,0.0020033144,0.007400426,0.029987102,0.06267008,0.016950842,-0.026902396,0.05185707,-0.011345816,0.08533286,0.047308408,-0.04943554,0.04650814,0.014154564,-0.019952532,-0.080565155,-0.063748986,-0.010641721,0.06773847,-0.04385594,-0.014238912,-0.019855363,-0.05488338,-0.051673893,-0.007028624,-0.041669536,0.08872616,0.060526635,0.044129718,-0.09757356,0.04440754,0.032940064,-0.08122714,0.016227536,0.016454604,0.035412237,0.0443607,-0.0038703266,-0.012155261,0.054369736,-0.04160906,0.028010763,-0.0690858,-0.05850043,-0.043682653,-0.027231181,-0.036783703,0.062331684,0.061961714,-0.0004043049,0.0020766065,0.07741837,-0.09316143,0.06345727,-0.06576559,-0.029071396,0.107711904,-0.034908786,0.046210416,-0.015514827,-0.037256125,0.03937265,0.053271186,-0.008970473,0.02283793,0.009575736,-0.03266322,-0.023711326,-0.09654691,0.08739819,0.09685622,0.012722116,0.06385557,-0.005997363,0.052068703,-0.076834574,-0.02244705,0.038887847,-2.5404123e-08,0.058517106,-0.054215327,0.0814115,-0.10861468,0.037050955,0.013377489,0.017680062,-0.02768716,-0.034232315,-0.011848551,-0.074285254,0.07716534,-0.012140243,-0.0020851824,-0.00191881,-0.03885418,-0.024656385,0.07108242,0.012724952,-0.05681437,-0.095576875,-0.015705986,-0.121568665,-0.020381005,0.03913737,-0.074086994,0.012125806,0.013920014,0.010433671,0.03624149,-0.028016467,-0.023227263,-0.01154937,-0.031799905,-0.011809768,-0.0026701593,-0.064437434,-0.036406334,0.06258003,-0.0153648555,-0.060950506,-0.039610118,0.037289407,0.009420743,-0.03374796,-0.029740304,0.0047943243,0.027066259,0.017354012,0.014600853,0.026787143,-0.040684085,-0.027498895,-0.05570356,-0.09103433,-0.026577506,0.026054272,-0.05480634,-0.045954656,-0.007225701,-0.04998683,0.026532406,0.14544906,-0.0075360746 +2.4.1.354,"The enzyme, characterized from Prunus dulcis (almond), is involved in the biosynthesis of the cyanogenic glycosides (R)-prunasin and (R)-amygdalin.",384,1.0,-0.07346917,-0.018970765,-0.16458683,0.055951327,0.00067218655,0.061713163,-0.014421807,0.0078117326,0.08276014,0.0022958538,0.06913944,0.02246817,-0.048540637,-0.05324543,-0.0139984945,0.026612053,-0.07244622,0.038726684,-0.047911465,-0.008294643,0.033394285,0.038207047,-0.06890115,0.012950715,0.015635215,0.002732384,0.027697582,0.013084689,-0.011939507,0.025563339,-0.03540629,-0.093256,0.06773487,-0.05043915,0.010142509,0.08516923,-0.124216445,-0.1108913,0.0063891257,-0.06104432,0.037175022,0.002407751,-0.021274114,-0.011924878,-0.06298108,-0.085281424,0.027141193,0.024832662,0.015536877,-0.037112623,-0.058995638,-0.04237657,0.010026638,-0.048468456,0.032526497,0.030152591,-0.10797904,-0.019544339,-0.0153430365,0.03935009,0.003386969,0.0030421366,-0.045287017,0.033663858,-0.104562655,-0.014104834,0.0041170926,-0.035960108,0.04942164,-0.06005795,-0.0298358,-0.054800954,-0.050418623,-0.022103384,0.07730802,0.053630337,0.027633848,0.028189447,-0.0811091,-0.068705745,0.07900339,-0.016339172,0.044062953,0.059503682,0.005725547,-0.013616858,0.084304065,0.029443627,0.007654524,0.024002,0.116655864,-0.02029108,-0.015753003,0.006953992,0.0058281133,0.10614619,-0.04440923,-0.073165834,0.005344539,0.014706143,-0.012642349,0.07641187,0.051541694,-0.058069635,-0.066987194,0.048142545,-0.05410463,0.043967806,0.073529154,-0.018917896,0.003131567,0.049726468,0.010532042,0.031687975,0.003745076,0.024520174,0.011558666,-0.05081381,0.038742185,-0.006977532,0.02990281,-0.0044823703,0.015799992,0.06716004,0.039391633,0.04140251,-0.13920233,-1.70866e-33,0.061699852,0.00013818842,0.06423181,-0.06801782,0.060723297,-0.050035927,-0.07140981,-0.026007801,0.022470204,-0.028220894,-0.09594853,-0.07307381,-0.042064395,0.04820792,-0.057258613,0.013227313,-0.025624866,-0.0026790474,0.11005224,0.023090566,-0.038812146,0.104538314,-0.038869955,-0.00067391415,0.007061776,0.10649938,0.054975893,-0.0074910275,0.06768425,-0.026499433,0.008845465,-0.057595115,-0.10627565,-0.0021187835,0.08065096,0.027269835,-0.017344883,0.0023432707,-0.0047046714,0.1085784,0.046892464,-0.030353544,-0.018326705,0.052885555,0.052609,-0.0031458596,-0.052368954,0.1095681,0.02937572,0.09707236,0.035122592,-0.0029770527,0.098214306,0.054653898,-0.11042049,-0.026365139,-0.012736474,0.020904548,0.0076581864,0.016727824,-0.026104365,0.07117375,0.010590083,0.01075453,-0.0038616857,0.023427682,-0.12559335,-0.0423422,-0.0022138173,0.033935178,-0.005345482,-0.046100236,0.05468085,-0.03383873,0.015061882,-0.05252768,-0.020869052,0.059316203,0.018115886,0.038116038,-0.0866639,0.010904941,-0.034203522,0.009445128,-0.07026116,0.011615083,-0.09370682,-0.0554697,0.037328333,0.02212674,0.024433423,0.058625657,-0.017834343,0.010058027,-0.0584935,-9.589759e-34,0.019417282,-0.13652126,0.042733885,0.01746548,-0.001410189,-0.012683136,-0.074129485,0.013613309,-0.046320982,-0.06909133,0.04893702,-0.0007516614,0.015223547,-0.029048877,0.0016179215,0.068976946,0.0343193,0.1225,-0.061383188,-0.017308535,-0.070476405,0.08852907,0.044748012,0.024607517,0.058667466,-0.035301078,0.07597824,0.07975021,-0.0021420412,-0.0055234856,0.02644942,0.018209035,-0.059653223,-0.010942256,-0.04026905,0.021555156,-0.08346005,-0.06491041,0.022351934,0.009116381,0.035309967,0.017893324,0.0006538478,0.080051996,0.097951874,0.039572347,-0.04761885,-0.017903248,-0.051892366,0.0029644712,0.026781196,0.02870685,0.037630036,-0.0011323541,0.0791179,0.0020970039,0.0017204864,0.047407623,0.03208894,0.020172173,-0.04621823,-0.075519286,0.008173947,0.0037754988,0.062377524,0.01764226,0.031692304,0.0423018,0.028233439,0.012942927,0.09616241,0.03459859,-0.03357574,0.029889595,-0.034334447,0.07491901,-0.034501757,-0.048640396,-0.021870932,-0.033405937,-0.028173931,-0.009794346,-0.041946862,-0.031672638,-0.05188963,-0.012899004,0.08207263,0.07878568,0.013848057,0.005701686,-0.0460551,-0.00024634972,-0.004646383,0.06910391,0.0075469925,-3.174517e-08,0.04050709,-0.09350207,-0.05528637,-0.034667164,0.0068542776,-0.015651608,0.047725234,-0.0064962553,-0.104175635,-0.008317888,-0.034133486,0.03176527,-0.034941413,0.0047567682,-0.009954271,0.051030055,0.0016742144,0.054736663,-0.010195582,-0.0062398114,-0.09301362,0.025529873,-0.15626335,0.06714488,-0.0021730904,-0.12992074,0.018717201,0.046772655,-0.01737035,-0.05699533,0.03851754,0.0068594404,-0.037601832,-0.0056464947,-0.04489529,-0.01652326,0.026009906,-0.03743939,0.00465615,-0.042962845,-0.055032633,-0.0455727,0.010036636,-0.022781206,-0.124115966,-0.05201416,0.007911853,0.024197128,0.032674063,0.044858754,0.043150194,0.04529024,-0.032295033,-0.076355055,-0.035514742,-0.004001766,0.06031959,0.01342168,-0.037790254,-0.017239261,-0.015409843,0.036544945,0.13289854,-0.023089929 +2.4.1.355,Involved in the biosynthesis of poly(ribitol-phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-beta-D-glucosamine to the OH group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.70 [poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase].,384,1.0,0.01913179,-0.060918767,-0.12948702,-0.0587099,-0.04533374,0.06515906,-0.080250934,0.0419399,0.089351095,0.022953223,4.001083e-05,0.0023188256,-5.913468e-05,0.03402273,-0.090358265,-0.054438584,-0.06438536,0.0003384812,0.029087769,-0.03878029,0.062244818,0.05386526,-0.048562866,-0.040226694,0.04314164,0.04682124,0.024905391,-0.053606644,-0.011466394,-0.033415362,-0.040574763,-0.049692973,0.114952534,-0.053046502,0.0492372,0.081901796,-0.019942164,0.0025755758,0.076731816,0.026156012,-0.00633929,0.017294325,0.061988283,0.0024210385,-0.008777484,0.0055859378,0.010511807,0.06185963,0.057363097,-0.010325642,-0.002176356,0.0153401885,-0.052256063,-0.020862326,0.008292038,0.03922039,0.013071417,-0.053276658,-0.005300566,-0.0005063778,0.059107248,-0.0451368,0.040355515,0.006620276,0.00719642,-0.04289336,0.06469551,-0.046263013,0.004889927,0.0020801104,-0.0491987,0.07947723,0.019047834,-0.015419271,-0.012854371,0.0055029537,-0.019836225,-0.042845037,0.006451192,0.019551568,0.017729191,-0.017090267,-0.053684,0.10792473,0.016628047,0.048774004,-0.026020544,-0.005087573,0.035581086,0.084970355,0.028731221,-0.00949053,0.04414987,-0.06300921,-0.02428423,-0.023489192,-0.011091915,-0.005319742,0.01522928,-0.074856974,-0.061801683,0.023056405,0.028924203,-0.048989955,0.0070827417,-0.018109161,-0.047996294,0.08822454,-0.011546791,0.04858399,0.03247607,0.052217722,-0.030536253,-0.020441508,-0.05980739,0.06284242,0.06441515,-0.13455857,-0.07743506,-0.051903892,-0.016351318,-0.080212094,0.036498763,0.05730267,-0.033458624,-0.049648732,-0.015710918,7.0636925e-34,0.05081175,0.05046961,0.037780274,-0.05727655,0.019155815,-0.0028473472,-0.06387159,-0.08416814,0.017699428,-0.021206304,-0.13993354,-0.048817825,0.08539106,0.011020997,0.0631704,0.050204266,-0.0064104497,0.009963724,0.046949178,-0.008867846,0.008561266,0.10718472,-0.0023155937,0.035299663,-0.016769532,0.029682497,0.009265839,-0.022289706,-0.017903322,-0.012429363,-0.00787143,-0.030369632,-0.049702857,0.041461263,0.12568215,0.016202297,-0.09426301,-0.017979022,0.119855694,0.028310552,0.06397842,0.038200922,0.052023266,0.010610084,0.04173002,-0.013946819,0.019230686,0.016381009,-0.025507929,0.08504653,0.0471299,0.023626136,0.027101755,0.0008602826,-0.07415327,-0.008447402,-0.049080726,-0.016731052,-0.0012194467,0.112986885,0.01958905,-0.007036848,-0.0465782,0.040875252,-0.07956635,-0.039565817,0.015837144,-0.037299335,0.026268696,-0.008657482,0.015822876,-0.08871609,0.042435225,0.024901781,-0.052935213,0.046769537,-0.03251652,0.013508964,0.052101806,-0.05915168,-0.01688707,0.03475952,-0.03141185,-0.080506355,-0.051776543,0.06569037,0.067256495,-0.060841035,-0.0051487703,0.022474837,0.011019557,-0.10967881,-0.05354067,0.07606094,0.0007886871,-3.2665508e-33,0.09036222,-0.20346862,0.072612,-0.121455505,-0.070315264,0.052935492,0.012040911,-0.031909607,-0.01723669,0.0037413025,0.0742746,0.05268196,0.009974381,0.021711212,-0.00619074,-0.044826653,0.05346992,0.09238246,-0.06193575,-0.042561647,0.0059340564,0.012578535,0.03556215,-0.0064645265,0.008736712,0.05489415,0.012208131,-0.001813979,-0.011121907,0.033514813,-0.023318376,-0.011232935,-0.05797304,0.035434354,-0.05338167,0.0113603445,0.012931723,0.013771178,0.074068576,-0.0068235644,0.022522308,0.060488567,0.03398889,-0.003432711,0.049052715,0.07828446,-0.04381106,-0.029229674,-0.06859488,-0.07100841,0.05657996,0.040790696,0.0541433,0.045302857,-0.0059545957,0.054223437,0.009994893,0.026380591,-0.004360307,-0.040739566,-0.054833926,-0.07202866,0.0127693,-0.032806695,0.012354778,0.0053691445,0.035953354,0.00787888,-0.006396475,-0.0493707,-0.01654333,0.035180874,-0.0137060145,0.06126026,-0.04965191,-0.12690613,-0.111630306,-0.07647671,0.00211327,0.0034750686,-0.041429408,0.016439712,-0.013499542,-0.0062573934,0.021412725,-0.08538387,0.104878075,0.09269239,-0.01855216,0.06026295,-0.034875117,0.040535927,-0.07796413,0.039227173,0.0794891,-4.2624865e-08,0.05438964,0.012117424,0.045915358,-0.056692127,-0.04750747,-0.012897372,-0.051842507,0.008923276,0.07452502,-0.039959602,-0.030125096,0.053427886,-0.041919407,0.0075359293,-0.0650068,0.07273044,-0.11397447,-0.09603039,0.01989176,-0.08427008,-0.07030786,0.01664549,-0.05623298,0.025938919,-0.032990202,-0.01041358,-0.009228298,-0.03127636,-0.001824843,-0.025528647,0.019990155,-0.0059908777,0.002213709,-0.087466,-0.04881811,0.021019144,0.092175566,-0.09420326,0.06445947,0.048103247,0.0017721851,-0.017693019,-0.05489834,0.04396135,0.005130723,0.04123324,-0.033473752,0.0405224,-0.04847195,0.012055491,0.07295192,0.028388944,-0.07143526,-0.041052755,-0.1128883,-0.005844333,-0.06129558,-0.11315319,0.0358137,0.08967726,0.018333433,0.0052019972,0.10686342,-0.019959042 +2.4.2.59,"This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.",384,1.0,-0.03748827,-0.0019446901,-0.10155728,0.0021163274,0.09240503,0.008518095,-0.082690366,-0.012330941,0.033523005,0.00041967767,0.0031605174,-0.038595077,-0.042374335,0.017888485,-0.062210668,0.014891285,-0.048047867,0.011251722,-0.0041653337,-0.025038298,0.0380219,0.08377955,-0.042543065,0.009975939,-0.029465795,0.03986908,0.06784707,-0.047923967,-0.08527329,-0.042519968,-0.12024559,-0.064862356,0.053219825,-0.033547517,-0.015708955,0.120014444,-0.07441824,-0.0037104131,-0.0055865305,-0.039598897,0.024999676,-0.025773512,0.03981481,-0.030425027,-0.08223961,0.00016984706,0.07194084,0.010086653,0.012723934,0.020970952,-0.06720805,-0.014778065,-0.03030047,0.0007611274,0.012553849,0.028891275,0.019157814,-0.036675762,-0.027402192,-0.011823463,0.06558303,-0.015922742,-0.03411739,-0.040659115,0.072591655,-0.02972612,0.051436882,-0.057293642,-0.019892339,-0.10452079,-0.03669133,-0.012151396,-0.029090416,0.012416352,-0.022926468,0.092746094,0.011876771,-0.04579388,0.05334324,-0.027492514,0.049111545,0.019639049,0.016106801,0.04938749,0.071115926,-0.030563068,0.01881913,0.05253518,0.03741446,-0.0031292173,0.07365471,0.05889462,0.021841139,-0.07504129,-0.055505063,0.020346126,0.004694681,0.07538864,0.02285026,-0.04355553,0.021240495,0.03744474,-0.036679056,-0.07354458,-0.04122454,-0.0071539422,-0.016975207,0.11704289,0.031827934,0.07319613,-0.0022163545,-0.017383136,0.04426295,0.013983975,0.0041042194,0.08035032,0.05567342,-0.04190335,-0.13134,0.038273957,-0.0026677346,0.01973938,0.07092606,0.07163313,-0.012615152,0.032047614,-0.15787363,2.0874225e-33,0.088307634,0.07924817,0.018512577,-0.06493292,0.04646811,-0.002207981,-0.054632545,0.02289967,-0.026634326,-0.038742542,-0.075331874,-0.040647227,0.047072235,-0.0696917,-0.05115641,-0.04362814,-0.034906074,-0.00577906,0.08199587,0.065639265,-0.011002174,0.07031476,-0.04654565,0.000712335,0.0046726535,0.0059978124,0.05572043,0.01688147,-0.015420466,-0.012133269,0.034965597,-0.13970597,-0.12215991,-0.09420317,0.15595883,-0.07916392,-0.01565826,0.022189334,-0.10440895,0.012189657,-0.023798976,0.030215496,0.022941802,-0.033409834,0.008323962,-0.09315513,-0.07223374,0.1205284,-0.010881101,0.03571584,-0.015911162,-0.005726672,0.08962309,-0.016184902,-0.062511556,-0.039495543,0.0017655526,0.007365918,0.051895093,0.036369104,0.032061603,0.038985625,-0.031985894,0.07641875,-0.02174202,0.003320426,-0.057545085,-0.014850803,0.039095476,0.12520593,0.040577024,-0.03039678,0.019240925,0.03436936,-0.051080193,-0.06381594,-0.08045067,-0.037079908,0.04142641,0.015320214,-0.015463417,-0.054500535,0.026354603,-0.02433466,-0.08148569,-0.02269375,-0.020397797,-0.012374622,-0.035879526,-0.021741178,0.07084904,-0.050673597,-0.04247544,-0.01215229,0.044039473,-2.6366952e-33,0.07713999,-0.08071838,0.07253067,-0.10149123,-0.034610618,0.04219323,-0.0065513994,-0.034792073,0.014531497,-0.020846302,0.076504216,0.0022177447,0.07311954,-0.037898254,0.042829063,-0.009158689,0.010199866,0.03450287,0.029945629,0.018944297,0.010924366,0.04283618,0.013701309,0.0052253148,0.02208453,-0.004766652,-0.034235153,0.10549345,0.008178141,0.07055914,-0.018855782,0.06157986,-0.031139795,-0.07693146,-0.07912816,0.020529933,-0.020173712,-0.027282236,0.060934957,0.05199363,0.0016364107,0.01018152,0.040084522,0.109065145,0.0041427608,0.055513,-0.04905827,0.054983757,0.028037881,-0.042908505,0.040573593,-0.0020646248,0.012267491,0.0084712235,0.0340428,0.021440098,-0.0027587595,0.07536336,-0.009886848,-0.007157039,-0.019089304,-0.09908144,0.05532833,-0.036325753,0.023094356,0.060203053,-0.03131018,0.038236637,0.015267025,0.015336448,0.032851733,-0.030407062,0.038784113,0.04535265,-0.018377302,0.003426171,0.030604796,0.05634262,-0.011465355,0.0066889906,0.0059097395,-0.013841037,0.029867336,-0.04962443,-0.017813295,-0.08888574,0.08792189,0.07867793,-0.094643466,0.03606844,-0.0812824,-0.02259396,-0.038794268,0.039412223,0.039237108,-3.537152e-08,-0.0059408173,-0.08932963,0.04348205,-0.061460327,-0.0064578867,0.03727018,0.06181689,0.026704451,0.06887732,-0.008443756,-0.028221512,0.088629484,0.029236851,0.055609036,0.082514435,0.03457526,-0.0005858962,0.028623821,-0.020365255,-0.0044174884,-0.03137457,-0.015855124,-0.090657756,-0.0040016957,-0.013669297,-0.02582543,0.016941004,-0.05341484,-0.05267031,-0.026437579,-0.0029234118,0.0046240394,0.005707504,-0.052982412,-0.059907712,0.06327241,-0.022477584,-0.03807751,-0.026149217,-0.030188503,-0.037141625,-0.011743477,-0.14551072,0.02368434,0.015997702,-0.012610177,0.0011273816,0.083720654,-0.05675894,0.0032051557,-0.0028891047,0.0062761777,0.05205429,-0.109567404,-0.00097063096,0.033980414,0.07921939,-0.05199078,-0.008879576,0.037943162,0.083607115,-0.026943713,0.16191879,-0.084127076 +2.4.2.60,"This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway. It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo [3]. The homologous enzyme in archaea (EC 2.4.2.59, sulfide-dependent adenosine diphosphate thiazole synthase) uses sulfide as sulfur donor.",384,0.99999994,-0.0531609,0.0059507624,-0.11291703,0.0009359706,0.043278534,-0.008217448,-0.09232619,-0.023892526,0.024069853,-0.006645938,0.0043872977,0.0035960681,-0.04571309,0.009919787,-0.055975758,0.035292603,-0.059297346,0.019109672,0.008099856,-0.041695792,0.04984782,0.08065579,-0.03364769,-0.021901196,-0.033609584,0.057981607,0.05623913,-0.031109508,-0.09007812,-0.053853665,-0.10582339,-0.053204373,0.010909896,-0.03941242,-0.027584795,0.11518171,-0.062408913,0.0045719612,-0.0031999757,-0.039400805,0.035995025,-0.018353662,0.0009482755,-0.034780666,-0.09262569,-0.03952318,0.050685804,0.011940404,0.02841358,0.011384812,-0.07729337,-0.012001372,-0.013914501,0.008829332,0.023551833,0.016313558,0.025325714,-0.027904902,-0.012634692,-0.023398176,0.04612051,-0.0075046127,-0.030604143,-0.054119993,0.062068455,-0.0357631,0.059984498,-0.07042084,-0.006432213,-0.09213613,-0.06295101,-0.012615003,-0.01806298,0.004647937,-0.00544901,0.09513253,0.0035041769,-0.04142319,0.054455567,-0.018437514,0.041681174,0.013315388,0.021366948,0.043522935,0.077198856,-0.050213244,0.0065243915,0.03886645,0.057070106,-0.0026919611,0.050908346,0.038942825,0.033755902,-0.044236366,-0.05732463,0.02593235,-0.01590122,0.08067917,-0.007229592,-0.04584102,0.035952985,0.017275194,-0.04595634,-0.07622104,-0.021582205,-0.011054596,-0.021946717,0.12247687,0.037209634,0.06765777,1.9302968e-05,-0.0013071953,0.047787365,0.010854031,0.0013075509,0.101893604,0.04937641,-0.027678473,-0.13322513,0.029084262,-0.021745797,0.03279408,0.054943018,0.036496196,-0.0077470248,0.011075565,-0.17003514,2.325988e-33,0.11195688,0.102780394,0.042161394,-0.06462297,0.024504688,-0.020119028,-0.06732821,0.032097228,-0.02878259,-0.036185276,-0.06617546,-0.051105607,0.015863614,-0.058910068,-0.05811484,-0.03758979,-0.013608748,-0.013900116,0.0940018,0.044357758,-0.032019477,0.044929408,-0.038822234,-0.020488873,0.010216817,0.020199157,0.06925205,0.017881302,-0.013405665,0.0019152184,0.06483807,-0.15912274,-0.107664496,-0.07768868,0.14377527,-0.07531144,-0.029470867,0.0358536,-0.09494028,0.011734892,-0.027829738,0.029985726,0.033842124,-0.043137304,0.0025515794,-0.09449941,-0.049097557,0.12243508,0.019136313,0.056179814,-0.037203923,-0.019009171,0.10914515,-0.002830539,-0.06639885,-0.039943766,0.022090131,0.0052087842,0.05874844,0.02243571,0.027347492,0.0276248,-0.044009533,0.06255403,-0.04370956,0.004463397,-0.070197016,0.003465029,0.034177117,0.12215082,0.02744428,-0.04164307,-0.005920249,0.047475975,-0.05095587,-0.06090157,-0.03682505,-0.026396329,0.050268404,0.015498196,0.0001630996,-0.057079893,0.018361833,-0.032588564,-0.09617716,-0.029455628,-0.034646686,-0.020375382,-0.037945453,-0.013855128,0.06050558,-0.025844453,-0.060540564,-0.011687638,0.053544533,-3.5073787e-33,0.08028561,-0.071595095,0.07538779,-0.10181106,-0.045027148,0.022920744,0.017976351,-0.0048603285,0.025464019,-0.014134045,0.08248875,0.0076955175,0.09558174,-0.06716315,0.051572394,-0.0011173666,0.029710922,0.035412528,0.036375403,0.009875486,0.0039593433,0.06492838,0.0059149475,0.011941998,0.0003347648,-0.0030009006,0.00309265,0.09132449,0.01698342,0.069959305,-0.001346922,0.051146053,-0.036330484,-0.066545516,-0.07514054,-0.0015811849,-0.025175784,-0.028191797,0.039146144,0.047750983,0.0047358316,0.003875789,0.04886664,0.13993967,0.016705465,0.03261265,-0.03650634,0.062291894,0.024256278,-0.068518266,0.054882977,0.012313355,0.026521878,0.0139379585,0.04626147,0.011500226,-0.0031471055,0.05338478,-0.020829882,-0.01189534,-0.028801048,-0.075723805,0.05511367,-0.054707006,0.015725747,0.056428064,-0.029178334,0.026927456,0.025633425,0.013764806,0.034065347,-0.017253822,0.016433725,0.010055305,-0.03785125,0.009519434,-0.01571472,0.0652838,-0.030308956,0.015671728,0.006506363,-0.012274368,0.037377592,-0.06845501,0.012406227,-0.09799553,0.0786805,0.09251845,-0.09317119,0.03448305,-0.08168129,-0.025209451,-0.058677316,0.03408149,0.011942506,-3.777968e-08,-0.034811173,-0.052872144,0.060292944,-0.030319393,-0.022110563,0.03433145,0.059440598,0.04063993,0.06698095,0.018357866,-0.0325719,0.10023227,0.044265956,0.040704537,0.07000891,0.037937697,0.0015788954,0.032549687,-0.021713184,-0.022251455,-0.02775002,-0.044614017,-0.08552744,0.029873045,0.021795854,-0.01134734,0.020964082,-0.06356793,-0.04561966,-0.05890641,0.0059120986,0.0018477387,-0.005038967,-0.05007717,-0.052186724,0.04588881,-0.010177557,-0.032998607,-0.011305847,-0.03946869,-0.027253607,0.0007779136,-0.1330122,0.05299399,0.016763939,0.016040847,0.005693291,0.088711545,-0.09183274,-0.028823115,0.017616462,0.005093256,0.040129676,-0.10463501,-0.02483647,0.049931534,0.08100924,-0.029876594,-0.013228614,0.030627096,0.09455085,-0.03647294,0.1287705,-0.06907892 +2.5.1.143,"This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN).",384,1.0,-0.04452544,-0.048352372,-0.1206008,-0.03713154,0.011446721,0.011302614,-0.025417337,-0.0005016614,0.0027588578,-0.005063169,0.081293255,-0.042995885,-0.11563941,0.013055003,-0.020815905,0.034683987,-0.09932332,0.026653444,0.058358688,-0.036332093,0.035309564,0.054750416,0.0099552525,0.03782493,-0.019601552,0.049969673,0.09464663,-0.02388515,-0.04707884,-0.07041375,-0.018899247,-0.069456644,0.0672681,-0.06440701,0.04862493,0.046945985,-0.06226703,-0.0030071333,0.044464894,0.028036168,0.061037887,-0.01635074,0.068006925,0.022822477,-0.0119554065,0.021714864,0.03527783,0.05519274,0.0153736435,-0.034078687,-0.018808234,0.03032517,0.031183844,-0.030433774,0.033647723,0.041833207,0.024442108,-0.041545097,-0.013465493,-0.053339206,0.101820886,0.01941468,0.0041186414,-0.0013679519,0.0020513511,-0.027014846,0.07853254,-0.09606909,0.029901825,-0.044069394,-0.04987522,-0.08471987,0.013730055,-0.026040986,0.033685,0.045619696,-0.007768813,-0.05744943,0.0699673,0.014626648,0.006133163,0.006544936,-0.024033172,0.05476594,-0.021466536,0.012762337,0.08142585,0.017268842,-0.017248087,-0.04030441,-0.011716149,-0.0018211581,-0.0006560394,-0.014607076,-0.17287487,0.016995164,-0.0015860718,0.054605033,-0.00558672,-0.040637396,0.03937478,0.0876801,-0.08727872,-0.11754446,-0.08592251,0.002809143,-0.02669382,0.0948161,0.061763383,0.08105216,-0.048901666,-0.0011526279,-0.01454342,-0.02556557,-0.042611726,0.10083403,0.0016427678,-0.05708919,-0.047513396,0.05323112,0.03663316,-0.04651458,-0.05282886,0.06650585,-0.09601339,0.013985673,-0.11315792,3.9639157e-33,0.042612396,0.0053473823,0.032764047,-0.025828974,0.04775363,-0.02562606,-0.119219676,-0.05102737,-0.0838193,-0.09488516,-0.021646244,-0.067762725,0.053866256,0.011054946,-0.049002375,-0.020651273,-0.10357754,0.052860443,0.05172357,0.041028306,-0.00039036208,0.09681979,-0.080531,0.08510874,0.06239398,0.1002245,0.016246876,0.0049432707,0.077156805,-0.0053744772,0.085463375,-0.12164825,-0.059732877,-0.04169745,0.097745135,-0.08227085,0.01590948,-0.022661854,-0.03547034,0.05027659,-0.025052119,0.023963299,0.014872954,0.026994029,0.016755689,-0.066163644,-0.023753231,0.11114907,0.03531741,0.008365223,0.057060122,-0.022946307,0.086269766,0.031830426,-0.038575705,0.024214508,-0.04158424,0.009596654,0.06546598,-0.037950087,0.059214614,0.044867173,-0.031937983,0.021829225,-0.018332655,0.020932246,-0.023038946,-0.03572475,0.06029634,0.0527932,-0.075693995,-0.022895422,-0.0346811,0.042010363,-0.035037827,3.0863153e-05,-0.05059929,-0.017689055,-0.0067513636,0.0046051503,-0.03996038,0.0037847417,0.021234911,-0.028655015,-0.018889569,-0.04723197,-0.10813985,-0.03679004,-0.022914689,0.033846665,-0.00035102072,-0.025095446,-0.043893475,-0.0066384077,0.019873144,-5.4523627e-33,0.08039753,-0.08207325,0.056188237,-0.050829962,-0.014549544,0.01730559,0.0074532335,-0.026132045,0.019548044,-0.03276942,0.03621615,-0.019535065,0.084107995,0.019292656,0.072816625,-0.003529617,0.033354305,0.10586207,-0.0007577081,0.019206006,0.06619152,0.056392483,-0.027921584,-0.03614997,-0.023588115,0.055139888,-0.044893004,0.008065911,0.019227922,0.032882806,-0.01764813,0.031489078,-0.061229028,-0.07006996,-0.07059106,0.032331027,-0.041184276,-0.023385847,-0.008764574,0.0012094529,-0.05490784,0.01588755,-0.015622672,0.021079017,0.010196901,-0.013014056,-0.033022143,0.026339667,0.027689336,-0.007113495,0.042641185,0.07413233,-0.005249651,-0.02782632,0.03251752,0.053729616,-0.023181073,0.011969851,0.072732486,-0.0024211844,-0.079441935,-0.075401545,0.057263777,0.009802327,0.026971862,0.02117068,-0.013714596,0.029702026,0.0600234,-0.08959957,0.0621434,0.14370315,0.03739892,0.08054435,-0.084852815,0.0020878739,-0.07073811,-0.04799873,0.025269216,0.06329047,0.009297173,-0.043356005,0.04453984,0.0075837257,0.02051075,-0.085016124,0.06468808,0.08658078,-0.04709709,-0.007471064,-0.019844908,-0.053388834,-0.021722296,0.062110003,-0.026814913,-3.9924018e-08,0.024851976,-0.058423445,0.031898525,-0.06523352,-0.0097593665,0.044523068,0.0040918114,-0.04208299,0.03351997,-0.08035144,0.097907186,0.05986257,-0.05205384,0.050612725,0.0684103,0.004342951,-0.004300293,0.00083790184,-0.01859189,0.009306996,-0.06497412,-0.009820169,-0.10685775,0.03932508,-0.012862644,-0.0071034785,0.0828525,0.039000917,-0.03169852,-0.022939835,-0.011058237,0.0018282596,-0.013150276,-0.0072504156,-0.0363837,0.032429926,-0.117174014,0.048278548,-0.05202576,0.0322975,0.0051083784,-0.041974384,-0.058612626,0.022234894,-0.031992715,-0.0055662864,-0.04410813,0.03400597,-0.078143,0.0020286716,-0.023052592,-0.023292473,-0.015095045,-0.023538291,-0.08377709,0.043015115,0.044817004,-0.08490119,-0.045798264,-0.010139112,0.015832674,0.03767531,0.18610443,0.01468924 +3.2.1.207,"This eukaryotic enzyme cleaves off sequentially the two alpha-1,3-linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature N-glycosylated proteins.",384,1.0,-0.04237592,-0.046996977,-0.13281977,-0.017954204,0.04185962,-0.024189243,-0.011112285,-0.022627078,0.031020014,0.019085614,0.033922967,0.039341457,-0.09960846,0.014861891,-0.050225545,-0.046017796,-0.007865249,-0.016627977,0.040154677,-0.035033945,0.07700446,0.033899248,0.016866555,-0.022425238,0.062473524,-0.057665408,0.04473934,-0.027147776,0.055649664,-0.034184825,-0.042118527,-0.113722056,0.028961066,0.024283005,0.015659796,0.05227432,-0.026917756,-0.049881946,-0.011602363,-0.020041848,0.043148987,-0.01883905,0.004649806,-0.018062923,-0.062912695,0.0010320803,-0.009540058,0.034041855,0.022081096,0.052121416,-0.018664831,-0.076234296,-0.06319001,-0.029723078,0.13006657,0.043029975,-0.098435655,-0.013220607,0.03613218,0.06253482,0.00675065,0.04063947,0.0021440748,-0.008683273,0.0005402971,-0.10230076,0.09533391,-0.046293642,-0.05319851,0.048983168,-0.026152965,0.0028900981,-0.025897313,-0.042635594,0.015097436,0.083504975,-0.086583406,0.028018132,0.0032140787,-0.025554134,0.06561002,0.016827745,0.10396342,0.07177455,-0.09583471,-0.056571756,0.023540163,0.053101372,0.05740896,-0.012444818,-0.010295734,0.0071998728,0.06294225,0.034735613,-0.026661089,-0.01260005,0.055539798,0.016383337,0.009654026,-0.039375424,0.00085349433,0.046094887,0.13117336,-0.015003549,-0.055532727,0.06731269,-0.015858922,0.09874091,0.022072693,0.057914104,-0.0096470695,0.07951034,0.030017423,-0.054787826,-0.11112667,0.045791157,-0.028683674,-0.06504293,9.423597e-06,0.028321847,0.026319113,0.02589534,0.039689653,0.010913916,-0.061146583,0.06901207,0.026050927,1.4057246e-33,0.06370549,0.015632663,0.0110975,0.034933478,-0.008650055,-0.012132357,-0.03367119,-0.036691334,-0.04801153,-0.008028905,-0.0181259,0.00695881,-0.009998149,0.111368105,-0.018569136,0.03318809,0.059295084,-0.023403624,0.04868609,0.060067236,0.007975498,0.06137604,0.028071236,-0.08325334,0.09560937,0.048016928,-0.057059497,0.03331691,0.07016334,-0.0068059037,0.06306434,-0.07155531,-0.12698425,-0.012419439,0.11910979,-0.013804342,-0.0034004052,-0.029823922,0.037376285,0.033386085,0.044329576,0.01935318,0.039052207,-0.062285792,0.02360631,0.009641024,-0.025412433,0.030227292,-0.046960555,0.055295557,0.03632683,-0.032432977,0.00130335,0.09108895,-0.033205636,0.058007807,-0.030630836,-0.06266161,-0.029785035,0.040537078,-0.013134996,0.029264348,-0.009846301,-0.02981565,0.0029044668,-0.01811281,-0.1064346,0.00914759,-0.009243906,0.0015140481,-0.026907656,-0.097657844,0.07234351,0.0022786492,0.0017899435,-0.08771131,0.0004957084,-0.011943349,-0.023512682,-0.031362634,0.05428212,0.04065933,-0.013453037,-0.054256175,-0.10599502,0.016586134,-0.025445303,-0.049986213,-0.08827334,0.026538217,-0.040636793,-0.026598046,-0.021331538,0.039564956,-0.03137501,-4.941107e-33,0.15306178,-0.1287137,0.11544354,-0.05315269,-0.060463697,-0.029030558,0.02032904,-0.11123401,-0.06718437,-0.009936609,0.06360917,0.016616767,0.038563367,-0.0077685034,0.043596234,-0.024756946,-0.06572618,0.13659713,-0.016267426,-0.017260963,0.027088627,0.03803461,-0.010090177,-0.05046516,0.039074004,-0.010476838,0.05850951,0.08459815,-0.018132236,0.044866297,-0.07301767,-0.0081061255,-0.023822568,-0.03599086,-0.0301467,-0.017773863,-0.028711466,-0.037362613,-0.014405844,-0.05940898,0.037338804,0.10364213,-0.020856889,-0.024528237,0.063108064,0.03372236,-0.034805443,0.038675394,-0.06916137,-0.05711242,-0.031219501,0.009243429,-0.06233435,0.020219095,-0.0023049233,0.08577674,0.05542271,0.019917564,0.051182628,-0.012944798,-0.013350548,-0.012383607,0.036568288,-0.0046167895,0.07360988,0.0022778236,0.02230052,-0.011097985,0.043568876,0.02622534,-0.0721195,-0.04709772,-0.00985737,0.006791605,-4.463933e-05,0.022468828,-0.123404026,-0.02360985,-0.009239312,-0.09030274,0.042876843,-0.046046235,0.03726206,-0.016556779,0.047091655,-0.10943283,0.11251232,0.08288208,-0.004397576,0.052718706,-0.014504158,-0.030043408,-0.00022301044,0.047973532,0.050913602,-3.1507703e-08,0.00804683,-0.007634576,-0.03560344,-0.05040827,-0.07158237,0.0027421832,-0.056388564,-0.016518675,0.0070011704,0.00791726,-0.00010736957,0.08409389,-0.044112444,-0.001127466,-0.028126631,0.05975061,-0.09020852,-0.017612595,0.003630058,0.06695761,-0.1225878,0.03031857,-0.089227945,0.030005902,-0.03478253,-0.06785078,0.019430652,0.09928661,-0.007159807,-0.02617885,-0.012404996,0.07252959,0.015391691,-0.09401543,-0.021888252,-0.045747302,-0.015610123,-0.009481659,0.023259914,-0.054853898,0.05616375,-0.012508895,-0.01419616,-0.039020915,-0.018525608,0.039233964,0.012353036,0.019713389,-0.091061205,0.0678221,-0.012188879,-0.0061581484,-0.043243617,-0.08074635,-0.025949074,-0.08492414,-0.083516024,0.012932182,-0.045001842,-0.013205028,-0.032841202,-0.008805397,0.1072948,-0.05832805 +3.5.1.128,"The enzyme, present in animals, fungi and bacteria, is involved in clearing cells of the toxic compound deaminated glutathione, which can be produced as an unwanted side product by several transaminases.",384,1.0,-0.026668075,-0.02287945,-0.06156985,0.05401508,0.01093251,0.0018126975,0.0052114027,0.09114578,-0.026170494,-0.02319314,0.083418876,0.020211227,-0.022086214,0.026755583,-0.08193454,0.016922694,-0.029764771,0.0040295385,-0.10229852,-0.074972786,0.04261811,0.026044896,-0.07646123,0.009775943,-0.016497364,-0.0033550006,0.015677376,-0.054484542,0.030852258,-0.05576946,-0.042387955,-0.020419335,0.0116857095,-0.03546264,0.0050698924,0.07519433,-0.08454654,-0.0072838953,0.07720149,-0.014843163,0.030273393,-0.03935655,-0.06335679,-0.026619017,0.022686742,-0.004772223,-0.05761047,0.003988979,0.028586961,-0.010525658,0.008308509,-0.0072864853,0.029717965,0.06390416,0.030407168,-0.05875068,1.6696249e-05,-0.046264466,-0.10390099,0.041000847,0.02521173,-0.05737708,-0.048605137,-0.09027182,0.02305351,-0.100297295,0.037033964,-0.01623203,-0.02606628,-0.0023507355,0.06264869,-0.057646975,-0.0027447282,-0.050890274,-0.035416488,0.02951467,-0.05973764,-0.026431207,0.026791397,0.029480938,0.13907216,-0.030692026,0.07483278,0.08230627,0.041019425,0.009678196,-0.014997474,0.013158475,0.0013874634,0.029358339,0.03760199,0.04632595,0.0072730063,-0.007939356,-0.0919497,0.04363527,-0.03181265,0.023700854,0.017855236,0.0022276258,-0.026484778,-0.014113474,-0.046512943,-0.062296607,-0.10195795,0.013770267,0.02168577,0.100912444,0.03125655,0.026259676,-0.041722223,0.017356534,-0.012993555,0.042454083,0.0054198937,0.14165805,0.14017813,-0.0427579,-0.116989985,0.0035267223,0.017527696,0.01627267,0.08345523,0.0724062,-0.00028386997,0.019794542,0.004641098,-6.6957655e-34,0.049140893,-0.00092823757,-0.05731269,-0.016227685,0.025186894,0.040887002,-0.101571105,0.003737695,0.03246191,-0.07708008,-0.08208009,-0.017944751,-0.038323328,0.022137713,0.01699186,0.012261216,0.025023514,-0.040661525,0.100485966,-0.019407881,0.06435634,-0.025033224,-0.07355551,0.01723708,-0.017682862,0.07671608,-0.03575578,0.010837733,-0.037131798,-0.0022750609,0.028603427,-0.08210338,-0.05248619,0.00070173637,0.054439206,0.018675866,-0.048337664,-0.036707204,-0.032816667,0.03798435,0.022111865,0.017595021,0.00044500592,-0.02701397,0.045891326,-0.060060166,-0.05997432,0.06723459,0.013636805,0.096760854,0.014491541,0.012872945,0.09183453,-0.055704,-0.09257674,0.037938744,0.011940653,-0.100657865,-0.010060477,0.059240147,0.02410061,0.083124384,-0.09814867,0.039327014,-0.021657152,-0.024999607,-0.047721762,0.011322576,-0.061735176,0.05834516,-0.083431624,-0.059272874,-0.031597096,0.04434495,-0.04550583,-0.073528886,-0.07192918,0.07752741,-0.03027583,-0.05189298,0.0035958234,0.009785734,-0.061872534,0.008799168,-0.05406062,0.01941804,-0.0015891682,-0.041554965,0.013194425,0.0059457766,0.08082619,-0.003823996,-0.0691673,0.042103715,0.0049887933,-1.4254562e-33,0.069537975,-0.083021596,-0.006333038,-0.0537174,-0.006172391,0.093593284,0.018476827,0.0109348325,0.0581807,0.028493509,0.007690833,0.016531495,-0.021481717,-0.0068950905,0.027023312,-0.0095754955,0.009947989,0.08413921,-0.040679477,-0.06993478,-0.0077451244,0.067954235,0.028965551,-0.027710345,0.06288553,0.038379464,-0.052863687,0.044434335,0.08256715,0.091603495,-0.004220048,0.021565849,0.030704742,-0.040403593,0.022866968,0.040865876,-0.029193588,-0.00038333228,0.053882185,-0.046941515,0.03249111,0.027835222,0.004641196,0.08901464,0.048963845,0.08709174,-0.09243102,0.056003246,-0.05296249,-0.089594066,0.08996462,0.027737863,0.023741834,-0.00893311,0.042134475,-0.027692903,-0.018328002,-0.03313,-0.032804973,0.024814313,0.019600678,-0.04664704,-0.0596361,-0.04087944,0.0028111495,0.0016468535,0.059769686,0.04172549,0.04530482,-0.02488709,0.016765228,0.028800327,-0.042756774,0.0032241286,-0.1060748,0.023179552,-0.10067394,0.002404663,0.0372737,-0.040187337,-0.0051632174,0.0055513857,0.029105322,-0.07297439,-0.02126444,-0.1434896,-0.051490974,0.14328693,0.0070617883,0.013290796,-0.043262262,-0.017692238,-0.05094527,0.058437508,0.011815241,-3.3486902e-08,0.010102927,-0.062313676,0.030789424,-0.06173637,-0.0012821471,-0.016314602,0.0013865681,0.048657645,0.10827745,-0.024002966,-0.06233254,0.11582856,-0.05456144,0.012773984,-0.005508713,0.043050934,-0.0030357258,0.020933608,0.011907415,0.048156343,-0.10740074,-0.04925383,-0.09844411,0.003254521,-0.029049402,-0.048451386,0.026697395,0.051896296,0.03480848,-0.0017288048,0.082021296,0.031219482,0.06576755,-0.0025935073,-0.08304784,0.035079155,-0.007675038,-0.03836923,-0.029716108,0.009495958,-0.014711466,0.05186922,-0.081914455,-0.005896571,0.025851823,-0.028426487,0.019247243,-0.016100775,0.021183867,0.025582869,0.014789045,-0.019249525,0.009947836,0.0030131028,-0.12681018,-0.013834945,0.040928397,-0.0751385,-0.004838414,-0.09200967,0.05094605,0.0428579,0.19307531,0.06112028 +5.3.3.22,"The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.",384,1.0,-0.02852962,-0.046499245,-0.06546357,0.014368385,0.05994132,0.06107606,0.005273102,0.03376249,0.029133456,0.030248273,0.04023523,-0.08752569,-0.053247217,0.06278066,-0.020386236,0.021645788,-0.07898363,-0.001557475,0.0050101876,-0.10266317,0.090320826,-0.00012420109,0.041008368,-0.010373637,-0.0031807295,-0.03369774,0.06742108,-0.039406303,0.016380114,-0.11808305,-0.018303484,-0.07217831,0.05170985,-0.026802054,0.03702733,0.06512692,-0.017518733,-0.11109366,-0.029234609,0.062432814,0.022344751,0.006052465,-0.049102377,-0.021632299,0.036051646,-0.02647312,0.013706212,-0.01854425,0.028167821,-0.013764303,-0.019836266,-0.07861231,-0.036691,-0.0010268439,0.029080948,0.063998364,-0.05879704,-0.022683391,0.036533106,0.028088732,0.1069026,-0.03541826,0.07416056,-0.022674704,-0.026361383,-0.043691255,0.058949348,-0.08276809,0.044890087,-0.09430115,-0.07679104,-0.071674176,-0.020239074,0.030923374,-0.033586394,0.0056793983,0.02089067,-0.042887174,0.021904333,-0.022462491,0.050518125,-6.783145e-05,-0.045312,0.078741446,0.14893237,0.016996453,0.029608477,-0.013949564,-0.018844847,0.005681225,0.018018495,-0.020433292,-0.0938651,-0.05975777,-0.036773354,0.027495563,-0.024348518,0.051707808,0.022377156,-0.06027254,0.016609902,0.009548438,-0.0014038184,-0.05567354,-0.06786578,0.0060521313,-0.017333148,0.084773935,0.0071207667,-0.01648057,-0.035080034,0.017485794,-0.0101998765,0.061940037,0.04326064,0.08341747,-0.013185409,-0.06068378,0.06569256,0.009022669,0.008197186,0.014733696,0.10272289,0.04624637,0.03252617,0.038946074,-0.11229721,1.544139e-34,0.05737847,0.050293952,-0.045484845,-0.047131546,-0.01571069,0.049033947,-0.05490968,0.124584116,-0.09855266,-0.10826035,-0.031762127,-0.012326263,0.04813598,0.062077753,0.013780785,-0.02370776,-0.0021217482,0.032893747,-0.029671056,-0.09939842,-0.054926507,0.025292788,-0.03666481,0.028506838,-0.022215081,0.003720095,-0.024571497,-0.030953618,0.09434883,0.0033331735,0.031962257,-0.039623067,-0.033138532,0.07046372,0.019780204,0.05158086,0.056512505,-0.03401609,-0.01694066,0.06512873,0.043702815,0.02020916,0.025932984,-0.06722573,0.05681471,-0.033779617,-0.098731,0.08360069,0.046601366,0.055465665,0.025009328,-0.020228155,0.08538924,-0.0709968,-0.039387677,0.05035786,-0.094771735,0.055779934,0.033246458,-0.014479733,-0.050942138,0.08084954,-0.0040229503,0.07900643,0.04246771,0.05412158,-0.049846962,-0.06923491,-0.055692688,0.025953852,-0.02910222,0.018436644,0.056446273,-0.011123953,0.052546386,-0.041697346,-0.112773985,0.03486219,-0.025767818,0.03293756,-0.046771057,0.009685374,0.03004546,-0.027573116,-0.018229583,-0.027309295,0.057625055,-0.013760793,0.032208744,0.00423844,0.10540765,-0.072031416,-0.07388864,-0.0020819271,0.012431736,-7.696914e-34,0.06216571,-0.07589201,0.07050606,-0.031070454,-0.019893458,0.022955775,0.04434854,0.029553028,0.03849514,-0.06252747,0.079533115,-0.031526726,0.04227506,-0.030836534,0.06756193,-0.020904582,-0.03967052,0.0334026,0.023185221,-0.018793637,-0.09669952,-0.04778382,0.0794569,0.050557926,0.04310256,0.06020623,0.011078567,0.012231833,-0.04278869,-0.037199438,-0.08072784,0.020618161,-0.050988853,-0.009894516,-0.02635379,0.022165328,-0.047206525,-0.040530972,-0.00782589,0.022281777,0.04446133,0.026306193,-0.009274485,0.01900859,0.049364787,0.081935264,0.0138639,0.10296172,-0.007681759,-0.06993329,-0.008166092,-0.009628517,0.006386509,-0.037188716,-0.0019589472,0.07820394,-0.031360492,0.056445938,0.020699872,0.034540508,6.4277876e-05,-0.04278499,0.04059638,0.024494788,0.030612307,0.026977887,0.018936379,0.06708605,0.022281907,-0.013382862,0.17485744,0.024185516,-0.025529161,0.03752401,-0.01784946,-0.007752198,-0.042774316,-0.022131419,-0.041902658,-0.021380357,0.037231177,0.0031246205,-0.014052115,-0.0281324,-0.0039337226,-0.02643993,-0.011526704,0.09684372,0.026301099,-0.042935237,-0.08188087,-0.030748708,-0.14411451,0.049422838,0.11436094,-3.1189927e-08,0.09281366,-0.006137606,0.0876709,-0.06541227,0.09836105,0.013478907,0.034746327,0.028323613,0.0030412944,0.018659359,-0.051957224,0.019003661,-0.020483013,-0.009539736,0.047087975,0.029251795,-0.000883746,0.035969954,0.0028427003,0.010695301,-0.045627654,-0.038422525,-0.06828979,0.0034959672,-0.047785405,-0.022100905,0.025510741,0.05547339,-0.018442927,-0.04590186,0.014633227,0.010672188,0.068011,0.029114215,-0.065963075,-0.009196791,-0.017006548,0.015163071,-0.09059357,0.033679977,-0.017405806,-0.05867486,0.022684403,-0.026002415,-0.061035775,0.0018630419,0.045163218,-0.032304533,-0.012209745,-0.033527896,-0.06351691,-0.067526005,-0.02325306,-0.0722847,-0.15593797,-0.066682756,-0.011203539,-0.08007534,-0.052930508,-0.06643459,-0.026091564,0.05397204,0.14626442,0.051491447 +5.5.1.31,"The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the hapalindole family of alkaloids. The enzyme is a heterodimeric complex.",384,1.0,-0.080892265,-0.040622715,-0.073294036,0.012584146,-0.07420944,0.0468489,-0.08096552,0.049370304,-0.02325496,-0.019229466,-0.006434133,-0.05137485,-0.06594623,-0.019906001,-0.036924995,0.093181215,-0.08150679,0.044056002,0.038671143,-0.013705178,0.076032706,0.057281327,-0.0007352304,0.02405715,0.01636914,0.047153115,0.03569608,0.020411333,-0.0022191054,-0.07890981,-0.0026768693,-0.046159215,0.09550588,-0.014318478,0.10110492,0.014425607,-0.08053136,-0.100534104,0.09521404,0.039061904,0.07289707,0.025526518,0.031646144,0.106891036,-0.08079612,-0.010383018,0.019844132,0.041172855,0.030606927,-0.0065719383,-0.058496628,-0.060343202,-0.027408773,0.04784738,0.008715276,0.01097852,-0.08888524,0.0048609646,0.082929134,0.01580359,0.12296306,0.099979915,0.010205376,-0.037366882,-0.021070348,0.0046207276,-0.0066648806,-0.07124396,0.047231935,-0.031114083,-0.009285513,-0.07209511,-0.064719364,-0.003185863,0.004469528,0.0025833948,0.028637588,-0.0454165,-0.04705615,-0.0011216211,0.017724263,0.029744895,0.10980352,0.07118441,0.00015338034,-0.00612079,0.064034894,0.02624518,-0.051899344,-0.01749346,0.08431931,-0.018818181,-0.049672667,-0.13013464,-0.012069353,0.05996042,0.01074939,0.07771093,0.03621489,0.0039483644,0.07409615,-0.03153331,-0.012689381,-0.06997997,-0.064911164,0.017812174,0.0142552275,-0.01833712,0.021040842,-0.02581028,-0.05441688,0.0040602474,-0.006447324,-0.004045552,-0.0353892,0.039429076,0.03500681,-0.036160123,0.008125612,0.06682392,0.030335184,-0.04953865,0.06285482,0.055922266,-0.006348158,0.012956355,-0.11402844,1.6408494e-33,0.027053613,0.065813914,0.010510589,-0.06293315,-0.007935253,-0.14158508,-0.05382831,-0.029840333,-0.11364019,-0.0013219711,-0.10866116,0.05739449,-0.014323586,-0.010073427,-0.04554075,0.06141995,-0.043246567,0.08751905,0.07432435,-0.011346886,-0.030358393,0.053442936,-0.067561336,-0.017786756,-0.06846632,0.072860755,0.014207471,0.0066194464,0.014196845,0.004465902,0.0064126365,-0.09906171,-0.08313058,9.445367e-05,0.0024778794,0.0002708462,0.004786697,-0.011080731,-0.06419122,-0.026068654,-0.028849332,0.0844778,0.025706159,0.02379554,0.09677689,-0.014145044,-0.054263316,-0.01941775,0.07382332,0.00781619,-0.043609936,-0.054118916,0.11567036,0.009900811,-0.018125476,0.01984849,0.01238342,0.14392206,0.0640715,0.045327116,0.013412281,-0.00077669317,-0.046366382,0.037695494,0.051450536,0.052320395,-0.04791368,-0.034782868,0.04278893,0.069283046,-0.053728066,-0.03650479,0.05470731,0.018578906,-0.0109278895,-0.019069731,-0.012589355,-0.017338788,-0.02754133,0.0017452637,-0.01631508,-0.046743516,0.07514103,-0.0485885,-0.02858583,-0.07499747,-0.0619624,-0.038652573,-0.053787008,0.09275554,-0.020415807,-0.031564977,-0.07170193,0.047042727,-0.0036500366,-1.9706377e-33,0.11124071,-0.116209,0.025118222,-0.085527726,-0.046694048,0.065023735,0.0066151917,0.056387424,-0.0015810106,0.030552076,0.13224146,-0.042631283,0.042823575,-0.0217213,-0.018841486,-0.011956539,0.04182893,0.082472965,-0.03152388,-0.012516684,-0.08597306,0.05101515,0.0007085069,0.012018857,-0.042994544,0.03695581,-0.0026775035,0.048429653,-0.007973564,0.06187231,-0.024059393,-0.014840962,-0.025879325,-0.048356112,-0.09069192,0.047654193,-0.03939542,0.0037609593,0.013359271,0.035777517,0.026372828,0.04429456,0.0069780946,0.02813094,0.08694612,0.020926058,-0.04565374,0.04296082,-0.023736246,-0.083747104,0.026231244,0.008276722,0.017205134,-0.009036132,0.0069900127,0.083326876,0.015772026,-0.021320876,0.008993721,0.0039346903,-0.04336627,-0.060085267,0.0033452902,-0.04653033,0.033225164,0.063300386,-0.0039036258,0.024139196,0.006089367,-0.011497371,0.023188483,0.037988108,-0.014737837,0.074133806,-0.018018022,-0.007058824,-0.00019446782,-0.091245055,-0.007814447,-0.030638516,0.061773185,-0.04422757,-0.042489994,-0.019336252,0.05547686,0.036823336,0.055329457,0.12242519,0.008849491,0.018524114,0.05076659,0.003749404,-0.08604598,0.0954706,-0.008113812,-3.094926e-08,0.07453804,-0.03793673,0.016872631,-0.023520112,-0.013652227,0.05347437,0.010462512,-0.028506402,0.005292769,-5.2949294e-05,-0.024779938,0.021672854,-0.024836857,0.019366022,0.069188654,-0.017351832,-0.019272301,-0.008876567,-0.017660279,0.029308219,-0.060000338,0.02958973,0.0015948549,0.0027060055,-0.023553625,-0.04967002,0.06596309,-0.02750112,-0.0032320048,0.06848537,0.0067487513,0.07094927,-0.033447687,0.056030396,-0.08220778,0.020306895,-0.042309232,-0.026585393,-0.031030444,0.0113463765,0.028914258,0.0001714125,-0.10824219,-0.01410662,-0.008685151,0.042554744,-0.019183887,0.039419144,0.00030442874,-0.046414357,-0.025514081,-0.063829854,-0.10109549,-0.028721632,-0.06261058,-0.012910464,-0.0020055415,-0.04965892,-0.040934287,-0.13541798,0.11800402,-0.020825252,0.14972527,-0.0024210257 +5.5.1.32,"The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the 12-epi-hapalindole family of alkaloids.",384,1.0,-0.09466137,-0.038425334,-0.07348062,-0.025508016,-0.06970432,0.06313543,-0.08128826,0.03503501,-0.018531213,0.0012020981,-0.0017533755,-0.050822973,-0.041762248,-0.04253033,-0.050588682,0.07769638,-0.08259661,0.053823255,0.034470987,0.015518949,0.078931496,0.024514807,0.03442612,0.035465747,0.033628456,0.05272699,0.026911715,0.03745931,-0.012319123,-0.07754151,0.019786349,-0.054334864,0.065207794,-0.041227214,0.1027032,0.029875971,-0.06331401,-0.0943377,0.10183336,0.045121323,0.044160075,0.042354945,0.025670975,0.09648837,-0.07113411,-0.041991394,0.020093495,0.041864473,0.039580297,-0.024263186,0.0032793104,-0.04932371,-0.029225668,0.053884067,0.032343,0.008036936,-0.105745554,0.003441056,0.072592616,0.021194221,0.10420013,0.062862106,0.036336888,-0.0011099312,-0.069455974,0.011330184,-0.035938844,-0.08194999,0.021897312,-0.023290083,-0.0072010746,-0.06297711,-0.061075464,0.012553746,-0.011232937,0.025029335,0.029514357,-0.02752071,-0.075047195,0.0071278834,0.0089893965,0.019340849,0.09413003,0.06641735,-0.002603592,-0.044810012,0.079399705,0.02774386,-0.039864276,0.005169939,0.11960497,-0.023003044,-0.028818864,-0.105460525,-0.0074889897,0.054626103,0.022165544,0.033495247,0.044321228,-0.016554745,0.049185205,-0.023309445,-0.020827113,-0.071998954,-0.07433404,0.023528682,0.001672384,-0.0185156,0.0033809172,-0.040983588,-0.03177704,-0.022929892,-0.013150081,-0.011632717,-0.030274997,0.0111355,0.0102134,-0.037562806,0.043640662,0.068106584,-0.020252895,-0.043455303,0.03048816,0.07166401,-0.015662484,0.011233228,-0.104270115,8.54015e-34,0.044655804,0.057030555,-0.022025954,-0.06462519,0.043023802,-0.11186676,-0.055163488,-0.025813574,-0.099855885,-0.042593848,-0.112467535,0.068814546,0.010939626,-0.015612248,-0.05051966,0.069251634,-0.049782746,0.07876171,0.07899061,-0.059237033,-0.06858037,0.016492069,-0.0629585,-0.040683966,-0.07388671,0.101343185,0.018777171,0.018039085,0.02577446,0.001406494,-6.301863e-05,-0.104914166,-0.087385066,0.006963922,0.009616504,-0.0056870324,0.040579144,0.01848753,-0.038305588,-0.03657118,0.010732778,0.09195565,0.012610805,0.031116858,0.1102827,-0.034356315,-0.04665094,-0.014295522,0.09033592,0.0034139182,-0.03347546,-0.046125483,0.107372254,0.025917087,-0.052299537,0.015566654,0.016514065,0.13616255,0.05373177,0.03938415,0.0057543525,0.038600743,-0.008261222,0.024855053,0.057447452,0.068055324,-0.025341919,-0.050723013,0.029580904,0.07199638,-0.059029758,-0.04115732,0.052745257,0.011762385,0.006926466,-0.005193948,-0.019384088,-0.014793761,-0.011651319,0.035078764,-0.013389645,-0.03361929,0.06727558,-0.014055649,-0.01806409,-0.065182954,-0.0762,-0.033765633,-0.024095492,0.11513466,0.010091693,-0.040240593,-0.045076203,0.07309554,-0.015017002,-1.5123971e-33,0.13132524,-0.1079451,0.063537076,-0.086852156,-0.045674942,0.05728778,-0.0119531425,0.07088799,0.027092485,0.04284078,0.13365947,-0.056025397,0.045960795,6.2736784e-05,-0.032557335,-0.017014591,0.04682147,0.113891006,-0.02423645,-0.024322916,-0.07434805,0.031871203,-0.0036602546,0.01762712,-0.047682177,0.030209158,0.022614155,0.031623133,-0.023034764,0.03800305,-0.009506974,-0.027047984,-0.057239156,-0.034698576,-0.09491506,0.032671664,-0.043063074,-0.007409442,0.008648411,0.027016455,0.047273405,0.037581835,0.006167513,0.0021524949,0.06866604,-0.005727414,-0.017060615,0.054016463,-0.031485103,-0.06529362,0.012270815,-0.0054421765,0.0071392823,-0.015657451,-0.00084004673,0.061150547,0.027305678,-0.011177356,0.019496592,0.00858333,-0.023214776,-0.051444743,0.015364583,-0.0467438,0.006187748,0.1010851,-0.0022651744,0.014949913,0.0026051628,-0.013115215,0.0009627057,-0.007360642,-0.018934522,0.07853183,-0.029807774,0.024725815,-0.012023779,-0.12404912,0.008754113,-0.04580207,0.0211208,-0.03650016,-0.068191655,-0.0038924492,0.047040164,0.045316663,0.044753235,0.092080794,0.0051451977,0.049087927,0.07544576,0.0030443114,-0.044327926,0.11396584,0.006250765,-2.9122557e-08,0.0806911,-0.047046408,0.029279081,-0.010754646,-0.007850154,0.049674787,0.018237906,-0.020949453,0.022836767,-0.074631914,0.015494523,0.022661192,-0.025530504,0.04132873,0.064885795,0.0029971718,-0.013243321,-0.012993434,-0.00619579,0.04289928,-0.07393433,0.03777074,0.04983814,-0.032103363,-0.015948525,-0.046113253,0.06846191,-0.007345973,-0.025114018,0.047193285,0.015758967,0.039416797,-0.056990404,0.037481137,-0.060953744,0.03992532,-0.037736278,-0.037572358,-0.05897664,0.01667662,0.011731714,-0.015256463,-0.100899436,-0.021767575,-0.015584993,0.03033842,-0.049907893,0.051759534,-0.018234475,-0.08404963,-0.018101685,-0.075081445,-0.067100726,-0.06455341,-0.08765637,0.0016700876,-0.0128614465,-0.061784834,-0.047474347,-0.10466723,0.10470093,-0.011944902,0.12148995,-0.009662015 +5.5.1.33,"The enzyme, characterized from multiple species of the cyanobacterial genus Fischerella, participates in the biosynthesis of the terpenoid indole alkaloids 12-epi-fischerindoles.",384,1.0,-0.06642232,-0.057383552,-0.0826789,-0.018319283,-0.09911643,0.073225714,-0.052995987,0.02293358,0.017695675,0.012519,0.028616881,-0.044802718,-0.11191797,-0.03178311,-0.039179925,0.06506111,-0.059875146,0.06414105,0.03490088,-0.008843825,0.04122608,0.04259175,0.033949867,0.03177693,0.024063073,0.06401801,0.038526226,0.033419404,-0.027753206,-0.023520255,-0.043810837,-0.013504444,0.022448651,-0.06343515,0.07635882,0.013093894,-0.053307917,-0.024855074,0.14711064,-0.00898209,0.034676317,-0.0028077522,0.003807848,0.056571856,-0.07833528,-0.031827323,0.015917296,0.08154875,0.019681985,-0.076834634,0.00532386,-0.037583217,-0.007957612,0.023753015,0.021475393,-0.04103218,-0.027709326,-0.03416419,0.0058497037,0.027033199,0.066996224,0.04392706,-0.0061686123,0.06493562,-0.07400804,-0.008118034,-0.031440116,-0.058081485,0.001726038,-0.018168269,-0.021367494,-0.09425034,-0.020903274,-0.004709435,-0.037034314,0.023009473,0.05986896,-0.019954909,-0.028190345,-0.01043701,0.020504816,-0.011551664,0.043232255,0.05325943,-0.03478217,-0.07820208,0.071254954,0.027222734,0.019965034,0.03264923,0.091707185,0.020549033,-0.008082611,-0.09981909,-0.06982838,0.037566487,0.038940493,0.029388566,0.029013133,-0.021999318,0.03354728,-0.0062687583,-0.067904904,-0.10352314,-0.07450931,0.033445045,-0.0063130874,-0.060003936,0.01530773,-0.009650564,-0.0025920982,-0.009648694,-0.022244364,0.012118826,-0.10219819,0.007968055,0.021524042,-0.038785387,0.053337995,0.11979913,-0.033378366,-0.009251712,0.028718615,0.1097182,-0.03228854,0.018019337,-0.040183462,-5.384689e-34,0.07749107,0.025044607,-0.035638224,-0.092190094,0.09242085,-0.06456098,-0.012479376,-0.020661721,-0.08688119,-0.022253454,-0.08043394,0.029849755,0.016531406,-0.007611942,-0.031634115,0.11920347,-0.07142447,0.06409001,0.068823,-0.014226908,-0.026320301,0.014736942,-0.036442377,0.011852208,-0.03428321,0.107421525,0.015979676,0.033895463,0.03214139,-0.0072185905,0.030993976,-0.10809145,-0.060867447,-0.042368133,0.06960042,-0.02199873,0.030281084,0.037092526,-0.06443724,-0.010038383,-0.008685563,0.07806557,0.007957912,0.025906838,0.054767463,-0.049435142,-0.042157784,0.037476648,0.05888755,-0.004873462,-0.012847944,-0.05762496,0.07954972,0.054148525,0.016604632,-0.0003938418,0.013544246,0.096311614,0.023875995,0.024735527,-0.0045015546,0.03401188,-0.027973374,-0.02258751,0.045677036,0.032994628,-0.023536181,-0.04687925,-0.025559178,0.044591486,-0.051072,-0.067599595,0.070579335,0.009039546,0.01010091,0.02126575,0.011974717,-0.037908062,-0.0072250133,-0.004659807,-0.044143725,-0.05040162,0.04762596,-0.040394977,0.006375084,-0.08372311,-0.109966606,-0.033196658,0.014154995,0.059237875,0.0070378133,-0.012439086,-0.11224076,0.07291308,-0.03627725,-2.7712685e-33,0.06404987,-0.08953302,0.02617876,-0.095221765,-0.055208255,0.04874489,-0.070858866,0.019266224,0.058390755,0.048469786,0.054715198,-0.043116696,0.0929144,0.02730303,-0.047891527,-0.09616769,0.051948175,0.12588759,-0.054976493,-0.004540841,-0.045045253,0.08407029,0.028092515,0.03638201,-0.039817832,-0.0093923565,-0.008482441,0.08540686,-0.095653564,0.059568662,0.06435212,-0.06271881,-0.055911366,-0.029546063,-0.025720648,0.08344837,-0.01577678,-0.009116642,0.07546686,0.10739148,0.02240318,0.0097106155,0.001325147,0.016088802,0.04224655,-0.06970526,-0.08828439,0.044306874,-0.03381208,-0.060248177,0.026061414,-0.012898137,-0.006661078,-0.025335472,0.000103079954,0.006030114,0.0068880697,-0.016698895,0.09631239,-0.01718635,-0.018934682,-0.104025476,0.047674514,-0.031565797,-0.011872508,0.078929976,-0.039878175,0.005503047,0.07107483,-0.004703875,-0.039296854,0.03744164,-0.02306783,0.07735567,-0.060334165,0.010634342,0.0036861938,-0.1756075,0.014010419,-0.0438224,0.008205863,-0.013220528,-0.0040711714,-0.014819107,-0.001308525,0.059087154,0.07190937,0.09248044,-0.029758194,0.036478844,0.07001331,0.017908135,-0.0592933,0.10376478,0.018628241,-2.7515407e-08,0.092495635,0.0075581507,0.04632296,0.036469765,-0.057644997,0.032609794,-0.0032433586,-0.018695667,0.04536372,-0.09381492,0.037115354,0.0700977,0.017800204,0.08171325,0.09499642,-0.00999633,-0.030399092,-0.012250214,-0.03133627,0.00026137053,-0.024549052,-0.016053239,0.019369654,-0.030279355,-0.008148291,-0.07977704,0.04163251,-0.014331051,-0.033889495,0.013365099,0.031378392,0.035468873,-0.056226917,0.043361988,-0.043388635,0.02620477,-0.06291901,-0.028137151,-0.038133588,0.014858964,-0.049868375,-0.02829784,-0.14367998,-0.0041078376,-0.024763566,0.0067046247,0.011097431,0.069235794,-0.014059672,-0.042191364,-0.021917485,-0.040470447,-0.014638638,-0.040090214,-0.05360791,-0.03775328,-0.019954624,0.006950194,-0.047504798,-0.07327999,0.033442214,0.0037393107,0.11918106,-0.040953565 +6.2.1.53,"The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It catalyses the activation of L-proline to an adenylate form, followed by its transfer to the 4'-phosphopantheine moiety of an L-prolyl-carrier protein.",384,0.99999994,-0.07198496,-0.05962935,-0.08843749,-0.066862844,0.06724523,0.08907182,-0.00037804947,0.10568957,0.05652407,0.030389538,0.043130122,0.039700743,-0.04226026,-0.0022442974,-0.015588668,0.063453205,-0.13060752,-0.04248108,-0.015061354,-0.109121025,0.09639587,-0.011853587,0.010770073,0.05437952,0.03253298,-0.04153455,0.058830142,0.079489045,0.016234295,-0.054501228,-0.024283411,-0.05503389,0.006197716,-0.029233249,0.100012764,0.053876318,-0.082612395,-0.065142706,0.024685247,0.032197062,0.086501025,-0.052445617,-0.09178985,-0.0152783375,-0.07130434,-0.0076909265,-0.0047687604,0.056942116,0.022244897,0.025516506,0.010233202,-0.0032667087,-0.063946344,0.009686672,-0.060905166,0.06814102,0.0016168514,0.018784929,-0.020293172,-0.0064642094,-0.02240705,0.003132122,0.008643856,0.011921114,-0.024750832,-0.043588974,0.026928276,-0.0148167815,0.03702794,-0.034025528,-0.03664755,-0.06605895,0.0512802,0.0635662,0.06164148,-0.02710799,-0.06926097,-0.03416367,-0.084915586,-0.051654022,0.07159691,0.0052549965,-0.0045826472,0.039918322,0.02578359,-0.030505653,0.025891194,-0.005386803,0.072096206,0.006542758,0.018885527,-0.06600994,-0.060681194,0.011006571,-0.07501511,0.03972229,0.012979398,-0.06261005,-0.038816,-0.05553394,0.008682458,0.027639993,-0.036322482,-0.08244595,-0.04946393,0.037172146,0.020300606,0.049168874,-0.023651721,-0.0164499,0.005392918,0.009660874,0.020625502,0.00045433984,-0.04642778,0.060849804,0.008517078,-0.08280981,-0.047084972,-0.036222816,0.0028927568,-0.023541067,0.04440749,0.106644705,-0.071707994,0.02999669,-0.049888022,2.988583e-33,0.048201304,0.06840227,-0.004121134,0.029789979,-0.0037931046,-0.03058991,-0.11545954,-0.017394401,-0.036575392,-0.040656254,-0.08645048,-0.10430949,0.03973256,-0.0076522552,-0.010674292,-0.035969608,-0.0057137897,0.06135963,0.02800085,0.037289064,0.0023334967,0.06071425,-0.015989048,0.032853812,0.049478024,0.10187394,0.0045069554,0.04678322,0.043990977,-0.00713656,-0.0027028266,-0.12067949,-0.053624153,0.01837498,0.047140494,-0.011388984,-0.08414223,-0.082638375,0.07207352,0.087435946,-0.016990243,-0.028978724,-0.0063832263,-0.0022837026,0.014977479,-0.05963583,-0.022628322,0.10581404,0.019833177,0.08565399,0.06785996,-0.025746172,0.08086304,-0.03171105,-0.108764865,0.010214833,-0.07850333,-0.06873021,0.020782378,0.018028663,0.0693799,0.04718411,-0.03773212,-0.014130001,0.025220305,0.024034768,-0.057770915,-0.047813933,-0.0034058676,0.07670834,-0.089551345,-0.017021924,0.0949889,0.033465054,0.039742194,0.044443775,-0.08736509,-0.014404821,-0.025349487,0.032824572,-0.012609962,0.031905487,0.015237553,0.0024770505,-0.019578984,-0.06427148,-0.023367988,-0.10326133,0.007919824,0.0034286727,0.046121947,-0.05513649,0.0029221734,0.059530634,-0.02861528,-4.9612643e-33,0.066263646,-0.058142796,0.10028093,-0.08479494,-0.05164358,0.034393422,0.010751067,-0.037498437,0.033811152,0.076390825,0.026671797,-0.015002716,-0.029316135,-0.057843525,0.034852844,-0.007345866,-0.036146857,0.053930964,0.009720945,-0.0010504236,0.035486665,0.011449746,0.03514834,0.0453351,0.0053558648,-0.006174612,0.02603325,0.04129469,0.055551518,0.046020154,0.041407976,-0.017943965,-0.06553602,-0.037597656,-0.03309707,0.059160907,-0.056997042,0.060035285,0.029977836,-0.018098295,0.048517067,0.014510605,0.058277328,-0.0379761,0.004433321,0.002578497,-0.042489965,-0.0007392368,0.021319924,-0.0575409,0.00081998436,0.067219935,0.02136734,-0.005321498,0.02415536,0.056266338,-0.05913476,0.016474864,-0.005025728,-0.016223064,-0.05313823,-0.08239251,0.013103494,0.045002688,-0.007298892,0.012282654,0.0048800623,-0.034271844,0.07703628,0.037992667,0.118114375,0.074023984,-0.05147992,0.04346872,-0.07357492,0.008273181,-0.016706109,-0.07750058,-0.018655334,-0.015232705,0.0015601187,-0.064200915,0.022041054,-0.11022366,-0.050657015,-0.014986687,0.034895178,0.13700071,0.02327964,0.007851172,0.037593916,-0.02306777,-0.00900474,0.038384333,0.04671173,-4.2216183e-08,0.023152651,-0.015486054,0.060600545,-0.06037391,0.012792236,-0.011334878,0.017833447,-0.05598949,0.049277466,-0.045732837,-0.05132724,0.027824983,-0.027658094,-0.0470476,0.06968424,0.12245243,-0.05349739,0.060461685,0.0028705096,0.0054399637,-0.056791544,-0.024569675,-0.16092175,0.054071184,0.019877702,-0.017351411,0.052718464,0.06269505,-0.023661787,0.030846674,0.056368664,-0.005337262,-0.011797836,-0.047363147,0.018909486,0.004530901,-0.030092554,0.034811106,-0.021144368,0.02335399,0.012422782,0.0284591,-0.0052434406,0.01952928,-0.0035600322,0.050563354,-0.029034398,-0.021606946,-0.040384438,0.056926873,0.03853912,-0.030765163,-0.04678719,-0.0737635,-0.13601123,0.0288206,-0.007557019,-0.07048146,-0.06045611,-0.08938174,-0.016178695,0.052187342,0.2108431,-0.037200663 +6.2.1.54,"The enzyme is involved in the modification of wall teichoic acids, as well as type I and IV lipoteichoic acids, with D-alanine residues. It activates D-alanine using ATP to form a high-energy (D-alanyl)adenylate intermediate and subsequently transfers the alanyl moiety to the covalently-bound phosphopantheinyl cofactor of a D-alanyl-carrier protein (DltC).",384,1.0,-0.037326176,-0.042302586,-0.013541219,-0.08744743,0.021917805,0.06474007,-0.016590483,0.04404767,0.058259822,0.067015685,0.003559054,-0.033314105,-0.07637958,0.049592678,0.054926544,0.006492126,-0.039265838,0.018498305,-0.018011319,-0.0673126,0.031086724,0.09201099,-0.013427043,-0.014212237,0.01816283,0.057857446,0.08798144,0.043731026,0.074856006,-0.03229449,-0.03281859,-0.09292479,0.01671496,-0.016921435,0.0019958483,0.065098196,-0.058440465,0.019728646,0.003885937,0.012682605,0.06763604,0.0036153102,0.015709212,0.026681963,-0.08376513,-0.05935883,-0.09441499,0.088356666,0.00529393,0.041978363,0.043831345,-0.06087748,-0.012655716,0.005206107,-0.0024405299,0.1235131,-0.030119004,0.031187963,0.0031381536,-0.023975618,0.040788863,0.058290526,0.030161696,-0.017074673,0.024667453,-0.030699654,0.00196915,-0.035968702,0.062920846,-0.13666192,-0.012098076,-0.051597487,-0.025684385,-0.018176097,0.05055494,-0.0325403,-0.06783497,-0.06885838,0.014002604,-0.08633617,0.08742472,-0.0053589186,-0.010390485,0.07741757,0.029894253,-0.01827867,-0.012654859,-0.0739114,0.06588434,-0.013649224,0.046703767,-0.080582686,-0.026904508,-0.022051325,-0.098500066,0.00064491155,-0.017641088,-0.009662628,-0.0490295,-0.0041423193,0.030549787,0.08426952,-0.11395434,-0.039225258,-0.098338984,-0.012054043,-0.03217296,0.062516354,-0.04274,-0.021512326,0.055808857,0.03954765,0.065661535,-0.0052693603,-0.034170825,0.05547404,-0.0044246926,-0.13046952,-0.024082217,-0.06953726,-0.010663773,-0.046107553,0.04573308,0.054354567,-0.027302867,0.03460086,-0.049549833,8.722029e-34,0.08379268,0.0010893376,-0.018338794,0.049700465,-0.0520573,-0.0741262,-0.05902641,0.003261085,-0.064462624,-0.019736188,-0.06875177,-0.059406403,0.0537119,0.009927515,0.011099543,0.005482121,-0.025952969,0.057006292,0.07185223,0.070382096,0.04420288,0.10887945,0.019078953,0.044449575,0.019491356,0.06441358,-0.018400548,0.01981757,0.101159945,0.022756293,-0.08337863,-0.012425737,-0.09761015,0.01255824,0.026894957,0.026576234,-0.13234422,-0.022726504,0.04502965,0.02206335,0.007877586,-0.03025539,-0.030331802,-0.026638104,-0.0049548713,-0.033971056,0.027533049,0.033127915,-0.017428612,0.025929559,0.07336163,-0.011141095,0.043334242,0.020478535,-0.07498279,-0.023127545,-0.042557653,-0.048372697,0.023091689,0.05875148,0.073221855,0.031992786,-0.047552455,0.096255735,-0.0077651143,-0.039006572,-0.054301746,-0.10380988,0.01095045,0.05151357,-0.043116853,-0.018961666,0.09322873,0.01181395,-0.010261679,-0.014064309,-0.03669943,0.014900398,-0.018438524,-0.048058394,0.017629754,-0.015773002,0.025086824,-0.026444387,-0.042817418,-0.027593737,-0.011534457,-0.079929926,-0.027290136,-0.05874822,0.0067907088,-0.041934155,-0.02831978,0.064538166,0.02705033,-3.680161e-33,0.042861022,-0.10781959,0.038655885,-0.089203976,-0.036456328,0.04433745,0.027361281,0.010721906,0.04219963,-0.043743905,0.06920201,0.029013757,-0.040804423,-0.022226464,0.044858612,-0.020300614,-0.0069909417,0.008102289,-0.0097560845,-0.03112204,0.0031400817,-0.023231734,0.00950526,0.044184253,0.030140566,0.018780392,-0.006076231,0.031622663,0.09474088,0.058245853,0.005255272,0.025620773,-0.050325632,0.045425136,-0.06499691,0.15973368,0.0058161085,-0.001161782,-0.031565625,0.034934722,0.003311563,0.037361234,0.05870166,0.010071784,0.03860612,0.05598449,-0.08566781,-0.043840047,-0.041932903,-0.07232672,0.09734741,-0.013480151,0.0525908,0.032251228,-0.015842501,0.09680754,0.01617232,0.057144105,-0.0091760615,-0.027978014,-0.05436362,-0.06495637,-0.016209498,-0.006139463,-0.006313558,-0.024404572,-0.007980183,0.00030819932,0.0024142533,-0.03442509,0.028638477,0.11897107,0.0362338,0.038590454,0.016042568,-0.09764984,-0.023005957,-0.037937302,-0.0007235072,-0.039180834,-0.061314825,-0.0004111146,-0.012118588,-0.05351394,0.017562633,-0.040444873,-0.007144132,0.09715865,-0.035358507,0.065102465,-0.05334571,-0.034523427,-0.06907247,0.038766906,0.09138783,-4.4280828e-08,0.028870573,-0.06150713,-0.035065595,-0.08111999,-0.026872214,-0.0040274155,0.020542337,0.031823993,0.03994529,-0.02789838,0.004413078,0.07848441,0.006707152,0.06661471,0.03398512,0.10627127,-0.09917171,-0.0027789057,-0.03868163,-0.056220047,-0.04265729,-0.023296826,-0.07207227,-0.012660971,0.0043663736,-0.029015353,0.05801838,0.042509902,-0.038094226,0.03976969,0.031629357,-0.015917875,-0.038047332,-0.044411812,0.017863154,0.06278752,-0.011025121,-0.032349944,-0.03908609,0.056711778,0.01512758,-0.022249863,-0.13858664,0.049161773,0.06846683,0.013157577,-0.09176451,0.08310635,-0.02950419,0.0511106,-0.0051687923,0.010090429,-0.008320937,-0.06341493,-0.123637505,-0.03750459,-0.0439766,-0.114298165,0.016601382,-0.05528238,0.06199602,0.03549635,0.14642681,-0.040157914 +1.2.1.100,"The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6).",384,1.0,-0.029229622,-0.016928906,-0.08072502,-0.035306845,0.05706814,0.074041225,-0.053187862,0.061700378,-0.0020625363,-0.00659514,0.015035145,0.008474107,-0.013749609,0.07097471,-0.08036893,0.08291903,-0.06849967,0.013633946,-0.028777527,0.06351765,0.023705948,0.105,-0.02051202,0.066147536,0.021201117,0.025927113,0.075922355,0.036625534,-0.015716802,0.011315571,-0.07167901,0.01709399,0.04927227,-0.045059785,0.08662023,0.10158755,-0.037202403,0.016452817,0.014502443,-0.047328927,0.03245892,0.0075295004,0.007841562,-0.04863714,0.01979351,0.024337513,0.027387502,0.053388048,0.09023742,-0.012071881,-0.11634722,0.001068442,-0.0063004247,0.03621371,0.027779233,0.030090354,-0.005783241,-0.01669066,-0.036318306,0.027517544,-0.020321192,-0.063413784,0.07348084,0.0019463692,0.038639177,-0.026911274,0.04482302,-0.010698866,-0.009908648,-0.07209936,-0.06534023,-0.06638265,0.026317779,-0.026145717,0.013072494,0.050418623,-0.09298243,-0.084416986,-0.04697215,0.008529001,0.0059799184,-0.08020506,0.011689176,0.11546931,0.02743174,-0.02673674,0.039054085,-0.014382283,0.032138407,0.024126608,0.027729895,0.02045487,-0.0043721627,-0.0350357,-0.07073636,0.029896675,-0.002904931,0.035074342,0.05471802,-0.041211177,-0.05660999,-0.016524434,-0.104327716,-0.035506263,-0.017479626,-0.029780926,0.0195049,0.09044077,0.055090036,0.027527926,0.0103498455,0.051409885,-0.05955721,-0.018690193,0.04438618,0.00408654,0.113919936,0.02295413,-0.10639943,0.071883835,0.00481374,-0.0018083581,0.04509668,-0.0010215342,-0.03702241,-0.046975937,-0.016927877,2.6934072e-34,-0.0094756875,0.021971572,-0.03447213,0.019947452,0.038828727,-0.034901,-0.07465525,-0.051384956,-0.02936629,-0.094337806,-0.017014895,-0.010040373,-0.01642556,0.016258793,0.02187002,-0.0074218465,0.000690933,-0.07338379,0.06949387,0.0043655224,0.09416068,0.022438053,0.0016933407,0.014430141,-0.011217273,0.0758208,0.10716348,0.07143624,-0.06770117,-0.049953423,0.020837966,-0.03915898,-0.17065126,-0.07795688,0.07822839,-0.056052182,-0.061122265,0.0118484935,-0.06791646,0.015449069,-0.054245565,0.003672969,-0.07231114,0.006215944,0.06509366,-0.075386964,-0.02586098,0.148044,0.025386717,0.013717403,0.0073010307,-0.068374336,0.07841442,0.012224253,-0.08874968,-0.07445311,0.02701508,-0.054745894,-0.0190785,0.035363805,0.061692733,0.0051620104,-0.0077337404,0.07517559,-0.03423269,-0.05470411,-0.0026800514,-0.022113232,0.030185513,0.0029621816,-0.013668544,-0.0064944853,0.0064195693,0.008327937,-0.0552528,-0.056306176,-0.07958967,0.017564775,-0.01919836,-0.033967897,-0.010677717,-0.06039223,0.03596461,0.02358276,-0.08043604,0.063782714,-0.0042983885,-0.05956433,0.043754973,-0.07082985,0.09318484,-0.10779008,-0.02401393,0.04278216,-0.052778658,-9.375665e-34,0.044641383,-0.015311043,0.10002465,0.012267689,-0.02646032,0.006831426,0.042890288,0.07344021,0.007834247,-0.049818207,-0.01292061,-0.0062820707,0.002964583,0.002612209,0.020226197,0.055546757,0.043639965,0.015259224,0.031028293,-0.06435802,-0.007109779,0.020448186,-0.06221867,-0.03247915,0.009023138,0.094830506,-0.002395175,0.06588533,0.045232665,0.040860802,0.021302508,0.07780937,-0.03751712,-0.026925055,-0.01710556,0.07670943,-0.07268073,-0.013491795,0.014080873,0.024500504,0.054435395,0.011487241,-0.02730879,0.020044226,-0.02647387,0.05255642,-0.030806566,0.04973039,0.035626497,-0.08411152,0.0519335,0.021649633,0.02048371,-0.004871118,0.022133753,-0.019845968,-0.0102817165,-0.032321937,-0.025199698,-0.010969941,0.019178525,-0.08014683,0.013919178,0.078664005,-0.023841493,0.099273674,0.07681223,0.023857163,0.0068198377,0.033489987,0.11273476,0.036355823,0.043343354,0.03299904,-0.10440311,0.01233759,-0.04809279,0.045548968,0.05656582,0.020430489,0.0406087,-0.021002475,-0.051961455,-0.06322679,-0.011714548,-0.102039374,0.07267256,0.054236844,-0.040804427,0.012944849,0.012200997,-0.016121846,-0.044000685,-0.02117592,0.00048737176,-2.8900024e-08,0.127923,-0.12027317,0.00939529,-0.041256085,0.0401591,-0.04918158,-0.007320806,0.09177596,0.1255935,0.020234814,-0.044994857,0.006734947,-0.0058834683,-0.037936486,-0.00043315458,0.06390662,-0.06590542,-0.00067408854,-0.018981218,-0.016662601,-0.07086948,-0.03789255,-0.10866709,-0.017055795,0.026248174,-0.03571676,-0.034051593,0.04478179,0.0148259085,-0.016655477,0.03049948,0.007066583,0.0721235,-0.044595998,-0.07729669,0.069346875,-0.035295453,-0.04874165,-0.03650261,0.023043567,-0.03376826,-0.063148595,-0.07920485,-0.008885875,0.008865068,0.006834961,-0.061781324,0.003568462,-0.039285164,0.0014124775,0.096405685,0.021829054,0.016306428,-0.009200569,-0.17122172,0.045166172,0.055264264,-0.047335673,-0.013989512,-0.0870461,0.010724149,-0.014937821,0.10021532,-0.049321223 +1.3.1.114,"Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses two subsequent reductions of the double bonds within the bile acid A/B rings, following 7alpha-dehydration.",384,1.0,-0.02733691,-0.09976627,-0.09750052,0.011581591,0.07441345,0.035156358,-0.018664606,0.018658753,0.036104914,-0.037065454,0.024210142,-0.06219729,-0.07289595,0.061870977,-0.022037784,-0.0016444714,-0.10570377,0.00762053,0.0012853837,-0.031516,0.043244526,0.021538429,0.10186289,0.059958514,-0.025928805,0.030886926,0.13085522,-0.019413462,-0.01503911,-0.106272094,0.072341695,-0.0430394,0.07885376,-0.056307744,-0.0064698104,0.0433194,0.040774904,-0.04620311,0.063806124,-0.022505865,0.00567889,-0.0006919133,0.050820254,-0.066895485,0.0072980556,0.015411716,0.020092223,0.08128095,0.020419547,0.08142556,-0.029178549,-0.04828741,-0.057480525,0.03812965,0.043384597,0.045131225,-0.026872054,-0.09985473,-0.012346524,-0.019853212,0.04236571,0.031328216,0.022518622,0.040539164,-0.029729784,-0.07066296,0.037519176,-0.050449878,0.015169237,-0.061384577,-0.006185772,-0.061176132,-0.005568158,0.015924009,0.0025803864,0.07541284,-0.011697292,-0.023010144,0.0115146665,-0.040263075,0.021201825,-0.06402366,0.015725685,0.15067048,0.06056621,-0.05800093,-0.040974665,0.016617779,0.014935321,0.02917033,0.024256865,0.006926723,-0.0035691536,-0.08801977,-0.03910159,0.05536201,0.031989526,0.01944602,0.0035648255,0.021296816,-0.030561466,0.03629737,0.04611363,-0.040734805,-0.06604944,-0.057637796,0.036718294,0.074441515,0.036239464,-0.090403,0.07019914,-0.0147671895,0.11116066,-0.04006948,-0.046718076,0.079728104,0.0024671922,-0.0860899,-0.06114685,0.078232065,-0.03063234,0.030801522,0.021464242,0.08642631,-0.008101874,0.010102904,-0.13977179,3.7176603e-33,0.04701344,-0.028122831,-0.0024783767,-0.04500136,-0.0042857514,-0.021982761,-0.007171429,0.04018717,-0.0068503655,-0.06701728,-0.010310956,-0.056349996,0.08659993,-0.0034941267,-0.028208643,0.0031016923,-0.0033729959,-0.010022411,0.038716458,-0.007329816,0.007275298,0.014748194,-0.018676918,0.027862588,0.0976688,0.039874267,-0.021856707,0.025925785,-0.0040006875,0.0075256457,0.008037284,-0.055604473,-0.03218772,0.04506629,0.1009098,0.04877053,-0.09639495,-0.046682086,-0.07262022,0.08183526,0.05033922,-0.057273153,-0.040096775,0.0358174,0.00870721,-0.048613995,-0.06296056,0.11182281,0.07134443,0.07276014,0.12902153,0.0061083348,0.05229216,-0.038514085,-0.03565152,0.06333621,-0.019851873,0.006755521,-0.0033015597,-0.00398836,0.042268552,0.06642499,-0.104170755,0.046411384,0.004229038,-0.007684601,0.026859129,-0.07291134,0.0008206519,0.009496077,-0.050616194,-0.031324387,0.045307916,0.025253328,0.021891946,0.008738373,-0.054382823,-0.04330534,0.035213005,-0.017055286,-0.04661988,-0.05822758,0.0047487174,-0.03670476,-0.09302765,0.024050588,-0.043020863,-0.0915651,-0.03127824,-0.041265238,-0.009033774,-0.08741759,-0.077685036,0.002021423,0.041223943,-4.726155e-33,0.0054279505,-0.09699234,0.0050447416,-0.025684588,-0.06619388,0.08228401,-0.016009532,-0.06970836,0.029660437,-0.04424611,0.06184836,-0.010897168,-0.0059778285,-0.06056225,0.0499899,0.07936863,0.024317468,0.051802576,0.04721544,-0.011651454,0.011261116,0.09831725,0.07051166,0.06268917,0.0099625215,0.031135812,0.019299688,0.010813208,0.08911638,0.11220893,-0.013287704,0.02712413,-0.025056427,-0.06951974,-0.077807546,0.016079962,-0.018308608,-0.041160677,0.005674395,-0.032190472,0.011936528,-0.010500452,0.058759514,0.007353899,0.004362171,0.07033091,-0.025120512,0.010128493,0.0020629915,-0.032199975,0.022071628,1.749376e-05,-0.03524014,0.010359932,0.014215606,0.06447132,-0.037762456,0.0076440834,0.0029964224,-0.11911647,-0.07380196,-0.04638806,0.05758991,0.031263534,0.045709543,0.030859632,0.010443301,0.04255441,0.037379086,-0.10653149,0.0037619984,0.0077543086,0.024014853,0.09446633,-0.045782708,0.051293425,-0.03993912,-0.023929646,0.024974676,-0.038487848,0.008356936,0.007987977,0.008053436,-0.08589258,0.018252803,-0.032125376,-0.088962644,0.05923133,0.060675602,0.035268284,-0.008043968,-0.007380374,-0.053952612,-0.07091989,-0.009565044,-3.757074e-08,0.040075853,-0.09502991,-0.015395641,-0.0006185558,0.04654406,0.05188916,-0.008111235,-0.010149797,-0.02375156,-0.035952453,-0.018790746,0.10303131,0.008856898,-0.010530317,0.0038372506,0.030707741,-0.037900083,-0.0070428597,-0.072384626,-0.05445645,-0.068246976,-0.004329293,-0.052586325,0.04047322,0.03486057,-0.012562201,-0.05648713,0.014499946,0.01889742,-0.03760255,0.054003544,-0.010182614,-0.00477662,-0.05724607,-0.09402727,-0.03967961,0.058676742,-0.055423886,-0.02445198,0.09671658,-0.015086139,0.04484173,-0.06984242,-0.007884467,-0.032573845,-0.020625412,-0.023654351,0.09222989,-0.03175994,0.011424376,-0.0078118336,0.0031552247,-0.04049443,0.01609948,-0.10995511,-0.03846986,0.052883122,-0.06601179,0.0016250189,-0.046956003,0.023165032,0.038530204,0.22845559,-0.008174467 +1.3.1.115,"Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7beta anomers. cf. EC 1.3.1.116, 7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase.",384,1.0,-0.04511072,-0.08508475,-0.13323475,0.011263167,0.0708008,0.029943576,-0.01383246,0.03306045,0.03293534,-0.0028765362,-0.008938803,-0.053559303,-0.12165585,0.077110566,-0.027169157,-0.008130618,-0.08642327,0.011928688,0.025153944,-0.035517044,0.040242642,0.028202603,0.079710834,0.058645148,0.005271922,0.0048663537,0.096768364,0.014732301,-0.04664585,-0.13434605,0.05375605,0.004123518,0.11344813,-0.019936638,0.00031765483,0.061624292,0.024487052,-0.09843463,0.04297018,-0.0013546655,0.013976098,0.012647181,0.062998645,-0.037021007,-0.035832573,-0.029610436,-0.019572495,0.061010096,0.044285446,0.06570269,-0.04081245,-0.031987686,-0.059955895,0.024279118,0.019977892,0.026376018,-0.017145675,-0.10596647,-0.012778382,-0.015715837,0.051798247,0.03289681,0.011361347,0.046219666,-0.066440895,-0.07827524,0.03689848,-0.066049285,-0.009884227,-0.04587308,-0.0008803132,-0.08235223,-0.0054904833,0.03655372,-0.0004358814,0.056904476,-0.009552055,-0.07580481,0.001038646,-0.07195399,0.029891735,-0.01934836,0.08418165,0.13465261,0.067889065,-0.055779368,-0.01893944,-0.00048797412,0.015085898,0.031560358,0.023978107,0.014757771,-0.016843634,-0.07894893,-0.017197408,0.053547535,0.033167537,0.010542437,0.00011237373,0.035952035,-0.02106415,0.024221092,0.01943766,-0.026587244,-0.05957017,-0.009954144,0.03160677,0.08259161,0.022220448,-0.09087285,0.042780496,0.02043918,0.1260374,-0.019133827,-0.07173859,0.07517133,0.0011821758,-0.10170788,-0.050601345,0.07446827,-0.025803387,0.020018406,0.05141317,0.08437072,-0.036755193,0.053995784,-0.09792528,7.4289994e-34,0.07476675,-0.040740807,0.019666996,-0.05034171,0.00083002815,-0.010868002,-0.001338019,0.056436237,0.04332193,-0.056140088,-0.057967443,-0.025981788,0.07591241,-0.0029711777,0.010978192,-0.014175106,0.0050925454,0.009975727,0.029292941,-0.017257102,0.019852946,0.018849555,-0.04031336,0.011892827,0.052085888,0.059215885,-0.038251944,0.025328001,0.027465561,0.020142773,0.00020100517,-0.075909436,-0.00372571,0.04431923,0.07533836,0.0087403245,-0.10819424,-0.03198668,-0.0343475,0.07710786,0.062367696,-0.029886626,-0.03842802,-0.019466538,-0.005685219,-0.013337887,-0.041815065,0.1352656,0.053792913,0.11676314,0.11277435,0.026699139,0.012410599,-0.021092642,-0.021375775,0.096473135,-0.055272996,0.007802726,0.077179566,-0.014737133,0.01811384,0.08099226,-0.080974355,-0.020416316,0.028102815,0.02463452,0.0081433365,-0.06385339,-0.056933872,0.008423662,-0.06238167,0.0017808452,0.05062114,0.01944723,0.019556217,0.04265061,-0.04329112,-0.03739481,0.044405345,-0.027951896,-0.032062337,-0.020573098,0.017864961,-0.048776627,-0.07087852,0.032357845,-0.04252587,-0.07993297,-0.04975176,-0.040374592,-0.0038798847,-0.066945314,-0.11610239,-0.04063433,0.0049518705,-1.9858324e-33,-0.000111456095,-0.08906876,0.028865766,-0.059055906,-0.04895908,0.05081114,0.0067042205,-0.043109886,0.05044164,-0.019817172,0.0596182,0.00234949,0.0095598865,-0.101807944,0.07758573,0.07889951,-0.022488426,0.09989037,-0.0023443482,-0.003316804,0.00164812,0.12048133,0.03566232,0.075127825,0.017060213,0.016953893,0.0086759925,0.003304386,0.079419225,0.111640036,0.03029111,0.01827907,-0.020384446,-0.04093706,-0.06363317,0.00018235754,-0.053856224,-0.02314032,-0.02706053,-0.030477053,0.01705563,0.005026997,0.056759533,0.015199908,0.06809311,0.06109583,-0.05428316,0.0290981,0.028700665,-0.030305782,0.023570161,-0.013418161,-0.036171615,-0.0313583,0.005015237,0.05143345,-0.012026263,-0.012830397,0.023579314,-0.088076435,-0.024940068,-0.04188016,0.050917007,-0.010717395,0.054724976,0.036962714,0.00074805313,0.026604615,0.04202668,-0.06087712,0.043108452,-0.014507599,-0.028463004,0.046194278,-0.047528107,0.004480083,-0.07108952,0.00509527,-0.018892806,-0.014168256,-0.011119821,0.0037159626,0.03247125,-0.104241915,0.021350367,-0.022366226,-0.038905755,0.031403787,0.08759465,0.064135805,-0.01088551,-0.007473768,-0.0412798,-0.05200352,0.021722024,-3.9762888e-08,0.07648913,-0.088360734,0.046672758,0.018225418,-0.0037142816,0.044118114,0.023665182,-0.014048375,-0.0034565674,-0.04157334,0.014113045,0.11090795,-0.0051283757,-0.018816827,0.014865974,0.029896334,-0.04595337,0.027192393,-0.06047209,-0.014473282,-0.061380066,-0.0033084091,-0.013057604,0.051533792,-0.005606633,-0.036183644,-0.028480941,-0.03209095,0.028295303,-0.07943697,0.059757795,0.048559137,0.008266138,-0.022441037,-0.124400735,-0.049654096,0.064724565,-0.053327285,-0.038438108,0.0716944,-0.05545537,0.022167053,-0.07166907,0.003049318,-0.044217207,-0.019289285,0.0030889264,0.06437231,-0.02052073,-0.0036333087,-0.008727569,0.01306741,-0.06536053,0.014868532,-0.077668086,-0.054700095,0.002758369,-0.045217674,-0.028555453,-0.070371866,0.027438011,0.014014889,0.23654225,-0.023431418 +1.3.1.116,"Contains FAD and FMN. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses the stereo-specific oxidation of its substrate and has no activity with the 7alpha anomer. cf. EC 1.3.1.115, 3-oxocholoyl-CoA 4-desaturase.",384,1.0,-0.024810696,-0.07343182,-0.08978593,-0.048059627,0.060932983,0.00815665,-0.06424889,0.059728537,0.024998793,0.004229028,0.012156133,-0.07361742,-0.068898335,0.07588543,-0.028958796,0.0050415182,-0.10652373,-0.0044008438,0.025419073,-0.057186294,0.012020326,0.02462271,0.02861685,0.010594323,0.021750571,0.0085636955,0.07318841,-0.0034676208,-0.026511036,-0.120859206,0.0464233,0.0023422162,0.0736618,0.005778869,0.025512436,0.02306914,0.050136,-0.017612915,0.08080064,0.025347982,-0.0128629515,-0.0014484633,0.018156726,-0.07971715,-0.04818123,-0.0002948103,-0.0025369343,0.004867549,0.02126059,0.0116426805,-0.01666241,-0.016252762,-0.041269325,0.047971282,0.023264663,0.041511323,0.028380612,-0.119718984,-0.020615367,0.02926723,0.011225287,-0.010492681,0.017148685,0.0016948415,-0.016318575,-0.06174259,0.008502472,-0.11682924,-0.014886216,-0.05219106,-0.017824566,-0.11172765,-0.009632129,-0.034901824,0.00988278,0.06779531,-0.035848673,-0.09566829,-0.012673305,-0.09059322,0.026333064,0.008018317,0.085078254,0.1129963,0.09385909,-0.05300053,0.005681679,-0.038556,-0.018244606,0.03886136,0.009576219,0.014415224,-0.017088218,-0.0902698,-0.018246023,0.07911363,0.038625147,0.05346133,0.03956853,0.023330294,0.008374285,0.075040564,-0.039535146,-0.043049116,-0.0893563,-0.040074527,0.01889595,0.11446505,0.008667469,-0.08771679,0.012383782,0.007648329,0.097292356,-0.0057990854,-0.029876303,0.04892522,0.051282134,-0.08493182,0.009670775,0.03236129,-0.010334024,0.022372838,0.01456281,0.13452709,0.021503428,0.028421737,-0.12920323,9.468945e-34,0.013020192,0.031868845,0.018850926,-0.05669445,-0.023002973,-0.021920536,-0.049529534,0.044806954,0.038038604,-0.03425889,-0.038793225,-0.018805582,0.0496155,-0.007568762,-0.038701877,-0.039222214,-0.0062172185,0.019909399,0.009793654,-0.056201007,0.044802185,0.020272257,-0.054857366,0.011362366,0.07144265,0.040942904,-0.051525228,0.05627279,0.02797275,0.00039056875,-0.03018028,-0.09380044,-0.034493834,0.028772691,0.047928534,0.020424515,-0.09326311,-0.00967065,-0.077195235,0.08353674,0.060867365,-0.00835158,-0.058498874,-0.02938666,0.014549367,-0.010030361,-0.039699167,0.13932723,0.045017872,0.07514085,0.10100876,0.00073780044,0.0082751345,-0.073536284,-0.026794525,0.07046513,-0.03754049,-0.010337906,0.09091634,0.00032236893,0.04597537,0.06443965,-0.119936295,0.02138605,0.07130362,0.0020445785,0.008545085,-0.053485155,-0.023538686,0.058927707,-0.06354837,0.015848,0.08035017,0.010785883,0.017505066,0.01481297,-0.077231064,-0.013896743,0.046064157,-0.0062862053,-0.027089976,-0.031900726,-0.022440221,-0.06513617,-0.046324894,-0.002822101,-0.04875679,-0.07180663,-0.027501708,-0.013634724,0.04785651,-0.0792348,-0.12384839,0.007644553,0.014750221,-2.0069599e-33,0.02959882,-0.086569704,0.02690013,-0.07432764,-0.044649407,0.09077583,-0.0008059047,0.018782834,0.04608179,-0.0344949,0.09451893,-0.014583946,0.018476613,-0.08584773,0.03756238,0.047369532,0.006645872,0.0833692,0.010757396,0.047017857,-0.014979416,0.13240325,0.013394602,0.09848078,0.034776773,0.040423367,0.009311246,0.030599838,0.07970635,0.10105459,0.016922373,0.038019422,-0.014747239,-0.06018159,-0.0490965,0.005049983,-0.069662616,0.00053837226,-0.021324443,-0.03392131,-0.0071796225,0.027887033,0.06113388,0.046546202,0.042257685,0.050399788,-0.04991299,0.02739635,0.047828127,-0.032000452,0.025951521,-0.022550728,-0.005379195,-0.07066042,0.010458133,0.077977516,-0.010431781,-0.00960681,0.015669718,-0.08055421,-0.024307132,-0.041045472,0.033744726,-0.004005157,0.031423386,0.018351713,-0.045487363,0.032252803,0.033037685,-0.048530504,0.04759628,0.025463475,-0.025818838,0.037117843,-0.050088026,-0.0069116917,-0.052141458,0.025349692,-0.0030480511,0.05624951,-0.02698428,0.016408477,-0.02610908,-0.07253285,-0.011354322,-0.017612161,-0.051369075,0.091665186,0.054543305,0.0044389046,0.009054882,0.014332254,-0.061814927,0.014183215,0.026399754,-4.0016104e-08,0.06498394,-0.11020001,0.0857542,-0.02716571,0.029299617,0.017312473,0.047047604,-0.04140518,-0.035771977,-0.041264247,0.0020468659,0.1265001,-0.014611849,-0.012448703,0.025699278,0.048305906,-0.002956746,0.0151628405,-0.028754331,-0.024454324,-0.048192754,-0.0031392092,-0.025640702,0.0619985,0.00086970476,-0.015723534,0.033706956,0.0052792104,0.0067387526,-0.050366707,0.053576622,0.035384428,-0.014951453,-0.038521424,-0.09393912,-0.023711486,0.06172321,-0.072219,-0.045140963,0.04737941,-0.013593367,0.009198496,-0.09977853,-0.01538779,-0.04793816,0.016923988,-0.029405383,0.040261332,-0.044530887,-0.0118085,0.0020306336,-0.0033199869,-0.038476955,0.028267281,-0.086637296,0.0034751112,0.026914455,-0.0676411,-0.03650981,-0.063624434,0.040018536,0.049962517,0.2461308,-0.023969384 +1.3.1.117,Isolated from Malus X domestica (apple). Involved in dihydrochalcone biosynthesis.,384,1.0,-0.0030191366,-0.015269303,-0.030918876,0.005233917,-0.0180832,-0.0012083643,-0.060490582,0.010831279,0.02784618,0.0043538827,0.08726443,-0.053878073,-0.100149654,-0.087352596,-0.022731112,0.05164589,-0.01209207,0.005245685,-0.013661448,-0.010249019,0.102364026,0.06378487,-0.017972358,-0.026434837,0.004804138,0.049232405,0.03530437,0.05786611,0.04935265,-0.07810639,-0.009129102,-0.019031761,0.026248276,-0.014638507,0.016463578,0.06392645,0.073887914,-0.046378314,0.09983751,-0.051826168,0.07292806,-0.0030765685,-0.009933996,-0.005038194,-0.08436837,-0.011368077,-0.055561237,0.025714703,0.054738987,0.01473106,-0.09852548,-0.053822212,-0.024317602,0.022065256,0.08698492,0.019102428,0.040501483,0.012103804,0.028332544,0.041735534,0.07125498,0.070616566,-0.014482283,0.04096011,-0.042470213,-0.0485751,-0.035544246,-0.0270753,0.0934074,-0.07049929,0.026520588,-0.037205677,0.0935019,0.05292636,-0.019637737,0.06266982,0.010310784,-0.025933161,-0.039723713,-0.026599148,-0.008263373,0.030611819,0.06744741,0.058833368,-0.060371403,-0.02216272,0.011093037,0.005393545,0.01812424,0.05731396,-0.020948263,0.029577386,0.05407154,-0.05315783,0.011165694,0.07708873,0.07603691,-0.08507745,-0.010836013,0.0047910693,0.021948641,0.016172023,-0.019565906,-0.062423047,-0.05447525,-0.021181779,-0.07819619,-0.021058278,-0.011469267,0.04203357,0.0437257,0.01684696,-0.02636402,0.02666977,-0.0391283,0.03245566,0.06648552,-0.029960668,0.00912658,-0.11199146,0.041222543,0.02024193,0.044691995,-0.022267625,-0.034653764,-0.004864436,-0.06388721,-2.6070268e-33,0.032232344,-0.00013568743,-0.0077669974,0.007081467,-0.014958491,-0.060294352,-0.044622816,0.057312306,0.0033910542,0.012360332,-0.07452988,-0.10476118,-0.0005337204,-0.023365814,-0.013321373,-0.034756105,0.046235416,-0.05234343,0.08317744,0.068524145,0.017682098,0.040535007,0.037095513,0.002088542,-0.008107242,-0.011376347,0.02260505,-0.053899184,0.13023439,-0.017340954,-0.005289985,-0.07559979,-0.011984046,-0.021813175,0.032700587,0.005224278,-0.031495787,-0.028426701,0.012612017,0.020008782,0.066579126,0.009260196,0.08210772,-0.057881497,0.05509562,-0.018494008,-0.07143055,-0.021395711,0.064739816,-0.033270717,-0.01311699,-0.012980969,0.056948688,0.06351065,-0.08026957,0.009663874,-0.027605766,-0.03318034,-0.002100631,0.09035358,-0.023474816,0.0761623,0.023146061,0.036360167,-0.032772347,-0.036860295,-0.04405846,-0.015341526,-0.09728437,0.07741093,-0.05456839,-0.090239674,0.06401711,-0.098406345,0.030460153,-0.081627764,0.004285486,0.013016292,0.023216728,-0.012267759,-0.004293617,0.07224433,0.056446426,0.003871452,-0.07850353,0.026570179,-0.11042796,0.0935721,-0.04386619,0.0818608,-0.009405593,0.025198838,-0.06297031,-0.037308086,-0.024137689,-8.873566e-34,0.036021367,-0.06431175,0.07814453,-0.061414942,-0.018962825,0.1235628,-0.05656135,0.018651927,-0.045342144,0.005408108,0.015477227,0.07203175,0.056503408,-0.116534926,-0.018367292,0.06625318,0.007870178,0.09749186,-0.023065077,-0.012562482,-0.024695905,0.0995189,0.044197123,-0.06964456,0.026063986,-0.060385477,0.04854265,0.09108799,-0.02184532,0.022968818,0.061757695,-0.0048581427,-0.06607188,-0.07265138,-0.018755756,0.014813946,-0.12643947,-0.11391608,0.004556438,0.060186587,-0.02782905,0.05196894,-0.011251123,0.091743805,0.06501961,0.061197687,-0.0704815,-0.017830083,-0.009085391,0.06550461,0.05131635,0.013109541,-0.08546612,0.04073101,0.00048073803,-0.028449537,0.018780354,0.048330635,0.016762208,0.013970851,-0.01675888,-0.060564734,0.009968624,-0.0520273,0.008402514,0.035075486,-0.048965935,0.10655942,-0.013885953,0.032086488,0.07285427,0.03497335,-0.08041096,0.0064587863,-0.007017289,0.03619509,-0.064801216,-0.05883025,-0.0026330499,0.04382573,0.043501396,0.10514299,0.044995483,-0.00015069325,0.047613207,-0.042228956,0.036742084,0.116051875,-0.057716988,0.043687418,0.02191539,-0.045350075,-0.06675148,0.032998763,0.058245245,-2.113894e-08,-0.025791772,-0.094417065,0.008068948,-0.022880139,-0.06532665,-0.059658274,-0.046749238,0.026571188,0.008351187,-0.017558217,-0.08586906,-0.04757708,-0.05310563,0.04014264,-0.013465612,0.0309147,0.033344194,0.10598932,-0.049893767,-0.024063535,-0.059679504,0.025166344,-0.11206533,0.014992113,-0.020458639,-0.0664465,0.016925812,-0.08071911,-0.0014345493,0.018837659,0.0023448023,0.008921907,-0.054599658,-0.093451954,-0.031009052,-0.05490776,-0.039719436,-0.034944367,0.006369981,-0.06281803,-0.0011112539,-0.04855946,-0.031653263,0.02329082,-0.06984077,0.020122254,-0.00717108,0.049628556,-0.031331427,0.031355705,0.018746095,0.022651963,0.07085451,-0.08977809,-0.09501018,-0.011490373,0.0019289238,-0.08033832,-0.01657446,-0.056547925,0.033080045,-0.0003863768,0.12886481,0.04706203 +1.3.99.39,"The enzyme, found in green sulfur bacteria, some cyanobacteria and some actinobacteria, introduces additional double bonds to the carotenoid beta-end group, leading to aromatization of the ionone ring. As a result, one of the methyl groups at C-1 is transferred to position C-2. It is involved in the biosynthesis of carotenoids with phi-type aromatic end groups such as chlorobactene, beta-isorenieratene, and isorenieratene.",384,1.0,-0.09498478,0.0018602733,-0.07767654,0.019444603,0.00085119257,0.09427582,-0.030879963,0.05248351,0.07854517,-0.04009289,0.07660255,-0.06714211,-0.08990196,-0.005135329,-0.015896972,0.055383712,-0.1101587,0.04213734,-0.009601424,-0.027629709,0.035420183,0.00063084485,-0.04032057,-0.028308075,0.00052848493,0.08084699,0.007050516,-0.035921138,-0.024744382,-0.046303853,-0.022367014,-0.06262662,0.0645451,-0.04671677,0.03975621,0.052695703,-0.033550914,-0.064892866,-0.00033262832,0.009318671,0.075249895,0.046525784,-0.018510872,0.02858223,-0.010164653,0.0038762868,0.017629081,0.07661784,0.0140233,-0.031920847,-0.015156735,-0.030428119,-0.04894936,0.037368238,-0.0018207288,0.03498707,-0.06411781,-0.019266883,0.049782697,0.006754538,0.104940325,0.020997368,0.059855618,-0.006535635,0.01334376,-0.06927222,0.02973512,-0.033412777,0.0241046,-0.1368149,-0.036396883,-0.057504367,-0.035164133,-0.057955176,-0.002910109,0.0366053,-0.00874986,-0.036684576,-0.008059767,-0.069368035,0.047417875,-0.03648859,0.006449811,0.067997634,0.026308067,-0.017535908,-0.008179912,-0.009519458,0.009305114,0.087461725,0.046246406,0.017487014,-0.0016538821,-0.035661116,-0.05140792,0.031793587,0.075619504,0.018947033,0.020272827,-0.015673991,-0.00036886169,0.056322295,-0.044517823,-0.09993706,-0.03137152,-0.025080107,0.0018268717,0.08649702,0.0071417904,0.022980012,-0.0034273316,0.043634225,-0.031543013,-0.083045274,-0.027531397,0.059591457,0.014423012,0.009110151,-0.044768073,0.028434921,-0.042108566,-0.05391286,-0.015021368,0.021225603,-0.0246726,0.0039948598,-0.15182923,2.8080003e-33,0.046180803,0.10710899,0.065456964,-0.0330805,0.018821007,-0.06262362,-0.09466926,0.023975985,-0.041622855,-0.09770365,-0.109778695,-0.076438956,0.024082437,-0.016704703,-0.022556504,0.013603277,-0.069166236,0.03366283,0.057266448,-0.02523409,-0.023355559,0.06144347,-0.035747554,-0.013239023,0.055500127,0.050201282,-0.008182556,0.014647932,0.0048887124,-0.009008289,0.042824462,-0.01920993,-0.0771281,-0.0054976083,0.16708338,0.0028846308,-0.0227056,-0.004221041,-0.04089629,0.026654257,-0.03350835,0.011192634,-0.01810519,0.01795165,0.005098918,-0.063815646,-0.03387707,0.03159463,0.08840719,0.032971594,-0.049582172,-0.017720774,0.088111684,0.040001325,-0.029275559,0.07500816,0.0031482927,-0.042501815,-0.05997034,-0.01563713,0.028753858,0.09801945,-0.033036936,-0.0090508545,-0.037335634,0.00010602123,-0.12101435,-0.022659792,0.026311176,0.037463672,-0.04339366,-0.06745381,0.018696394,0.020265628,0.04135526,0.0065656076,-0.061304953,-0.04126745,0.04037541,-0.044056106,-0.061403375,-0.040010095,0.04925307,-0.09758581,-0.030097777,-0.0031053165,-0.054269683,-0.06597616,0.0825357,0.08772557,-0.0030682047,-0.05700512,-0.05244624,-0.0047001764,-0.017293645,-4.689372e-33,0.041731603,-0.11975425,0.04303737,-0.06037478,-0.0004160998,0.015318282,-0.079640865,-0.07901502,-0.04289023,0.062403753,0.082973324,0.06869531,-0.0020686728,-0.0005529169,0.04335778,0.0058609215,0.087062545,0.09628686,-0.0038858918,-0.01203148,0.014776095,0.009241221,0.0031631123,0.034158684,-0.02155677,0.02974146,-0.016329678,0.021121763,0.12649004,0.02256328,0.010626029,-0.021373695,-0.024596684,-0.009306962,0.024617305,0.058977578,-0.07633974,0.026647411,0.057409424,0.096906446,-0.024136765,-0.062362958,-0.0038881295,0.082059376,0.050242916,0.02811713,-0.0013816942,0.03382822,-0.057218745,-0.06800954,0.073027186,-0.0020954441,-0.0072614094,0.052828707,0.028680654,0.033904854,0.038228672,0.03495996,-0.016894622,-0.023896778,0.018316086,-0.110766314,-0.00901527,-0.10600794,0.060732633,-0.06357201,0.010974152,0.058986403,0.033376876,-0.06136509,0.048540723,0.013086272,0.026132086,0.019821674,-0.109779425,-0.06260309,-0.02582649,-0.081500374,0.0018775382,-0.038586684,0.02578207,0.043666814,0.059262257,-0.05071785,-0.024422482,-0.034335442,0.07454234,0.09237116,-0.06422263,0.048873078,-0.051974233,0.06786754,-0.014454101,0.14173327,0.012377418,-4.3112657e-08,-0.010718968,-0.0152582675,0.077221915,-0.023727272,-0.002003977,-0.015958264,-0.064714864,-0.02579214,0.051740825,-0.029632214,-0.05061301,0.09916818,0.06496734,-0.0057349927,0.05468767,0.024361068,-0.020735562,-0.00742401,-0.0039165006,0.06160665,-0.100114666,0.0026958047,-0.14305864,-0.048865948,0.012298542,-0.085275464,0.05698183,0.04399434,-0.03633122,0.04097882,0.07296291,0.0028045597,0.010742039,0.0026649719,-0.04148468,0.01682597,-0.034294207,-0.06279396,-0.028979007,-0.0358032,0.035712913,-0.02132112,-0.09392638,0.0969069,0.011168402,-0.0009116944,0.009231846,0.060375385,-0.088276565,0.04145372,-0.012020183,0.001433045,-0.050650313,-0.05984373,-0.07646026,0.0055675646,0.036907304,0.0074186535,0.042519283,-0.005961487,-0.0053201113,-0.002383149,0.10038398,0.021858424 +1.3.99.40,"The enzyme, found in purple sulfur bacteria (Chromatiaceae) and some cyanobacteria, is involved in the biosynthesis of carotenoids that contain chi-type end groups, such as okenone, renierapurpurin, and synechoxanthin.",384,1.0,-0.11235587,-0.07414822,-0.060009394,-0.021280024,0.015470931,0.09042345,-0.05890326,0.010970102,0.041392058,0.00474536,0.06605671,-0.041035883,-0.055777658,0.0243578,-0.020172143,0.14094795,-0.09044647,-0.0038247865,0.009572357,-0.02314008,0.043831516,-0.013714716,0.0011820059,-0.010644764,0.03929518,0.07708134,0.0027331342,-0.0181417,-0.010776521,-0.011030651,-0.05797001,-0.06296527,0.049810987,-0.045786172,0.06929964,0.05379958,-0.051356778,-0.0032494632,0.026505122,0.020650288,-0.00217431,-0.0014000871,-0.06962957,0.0017509621,0.009502977,-0.03733571,0.007489813,0.04893447,0.008547601,-0.10244737,-0.0337276,0.014657041,-0.006900982,-0.041960776,0.004601128,0.058555458,-0.04447831,-0.08559049,0.016907465,0.039854635,0.043206953,-0.0033423074,0.0031488715,-0.057835788,-0.022474963,0.00655769,-0.03687605,-0.034025833,0.053562038,-0.08043004,-0.037710547,-0.0739649,-0.048393678,0.03350197,-0.021141268,0.03494489,0.032837246,-0.035622526,-0.04929561,-0.06209495,0.035031144,-0.02708974,-0.006909144,0.096989386,0.05255466,0.011397689,0.010830836,0.038538903,-0.005950832,0.065543294,0.03426216,-0.027199605,0.013053397,-0.042666722,-0.0181624,-0.008788293,0.08864274,-0.021523358,0.101286784,-0.030566532,0.020791039,0.034998547,-0.0028900043,-0.12198501,-0.012889855,0.014084779,0.009063641,0.095830224,0.03155326,-0.046263374,0.018643036,0.035976913,-0.0203216,-0.054313198,-0.06426312,0.088008374,-0.0035982504,-0.076151304,-0.10381752,0.12141786,-0.036311377,-0.009774759,-0.046486363,0.10453528,0.007524269,0.072131805,-0.15595143,2.0826007e-33,0.10337083,0.045819085,0.030983614,-0.09656041,0.035687916,0.02517499,-0.055095773,0.008917903,-0.006172796,-0.08592266,-0.10001753,-0.06832269,-0.049633585,-0.050861698,-0.048868794,0.05937237,-0.09229611,0.031604104,0.012346323,-0.03031526,-0.03145304,0.044162426,-0.06640259,0.0188282,0.00011972902,0.05000367,-0.03201179,-0.0020631144,0.09999174,-0.004987317,0.040194094,-0.050965536,-0.055916864,0.0066872514,0.086859025,-0.0114431195,-0.07584303,-0.058481414,-0.062441602,0.08704641,0.011886503,0.089758776,-0.01418967,0.040972378,0.0030363665,-0.07314831,0.044975586,0.02634733,0.048591387,0.03483815,-0.0289074,-0.010413242,0.092296354,0.007831965,0.02051623,0.008299087,0.011707724,0.020515447,0.028227333,0.013072615,-0.023407374,0.08093154,-0.02374971,-0.024154259,-0.0027124078,0.008302328,-0.08073517,-0.03887143,0.006437864,0.028425114,-0.030482931,-0.04627142,0.014688586,0.024231376,0.06518477,-0.013606857,-0.059983257,0.0044904025,0.0032113732,-0.058372937,0.009568176,-0.0209591,0.011759871,-0.055044144,-0.05362678,0.01584766,-0.015191337,-0.10139355,0.0032253289,0.03270482,-0.027875237,-0.08320202,-0.07086515,-0.01590633,-0.026946304,-3.1142563e-33,0.036730073,-0.08321321,0.07479159,-0.0113337,0.0015535408,0.042328645,-0.09868214,-0.022217855,0.038280074,0.080029435,0.044228204,0.034999922,0.09809059,-0.023121996,0.026154287,0.036192685,0.08603379,0.12425997,-0.045918897,0.010580521,-0.08584905,0.04770294,0.055313166,0.014946795,0.046283707,0.06354053,-0.028822076,-0.0056251115,0.098085165,-0.00035805008,0.013938944,0.036980554,-0.056505397,-0.04277837,-0.0058979867,-0.01508844,-0.06422787,0.0024687825,0.07142926,0.08650364,-0.05712073,-0.053691845,0.05988052,0.105503194,0.006055825,0.020220943,-0.048534352,0.021578113,-0.044817265,-0.06575125,0.06441084,-0.034318477,0.0035843814,0.02936124,0.06006864,0.009959738,0.034368046,0.09502632,-0.05849561,-0.014415663,-0.012874654,-0.09064488,0.018626554,-0.048247468,0.021955485,0.036676273,-0.007317817,0.06247243,0.036971565,-0.06055174,0.029259799,0.01861696,0.028640134,0.010732628,0.0063696764,0.020225912,-0.07148379,-0.07373911,-0.010397169,-0.027834153,-0.0010236222,-0.011144271,0.032931406,-0.03134828,-0.041307352,-0.03433434,0.024741825,0.11727109,-0.06031363,0.046655893,-0.02539256,0.018769765,-0.024948893,0.092832536,0.092151836,-3.3466094e-08,0.043784678,-0.05312171,0.053179447,-0.03217107,0.04192455,-0.012270859,0.017572839,0.050168112,0.023592373,0.027732655,0.009579354,0.05418483,0.03769651,-0.032738704,0.02720651,-0.013551359,0.030878881,0.00081606227,-0.01180397,0.08800377,-0.07684807,0.028055515,-0.09746128,0.008178803,0.012085215,-0.088591546,0.041783985,-0.011969205,-0.055758137,-0.0058625895,0.08100233,0.015844345,-0.020514429,-0.05010115,-0.06474666,0.033296473,0.0004481991,-0.06141834,-0.022788567,-0.026451005,0.031768907,0.005322702,-0.11897961,0.046796013,-0.019439925,0.00593286,-0.00780666,0.06546714,-0.05039385,0.0029507636,-0.016614025,-0.03959495,-0.050504807,-0.08615749,-0.08719298,0.007298748,0.06972627,-0.04214028,0.029774945,-0.03922798,-0.025264984,0.01586321,0.16999173,-0.0037127996 +1.14.13.240,"Contains FAD. The enzyme from the bacterium Escherichia coli (UbiI) catalyses the first hydroxylation during the aerobic biosynthesis of ubiquinone. The enzyme from the bacterium Neisseria meningitidis (UbiM) can also catalyse the two additional hydroxylations that occur in the pathway (cf. EC 1.14.99.60, 3-demethoxyubiquinol 3-hydroxylase).",384,1.0,-0.03641742,0.009623465,-0.095225856,0.011398153,0.047489762,0.018690916,-0.05409204,-0.03834393,-0.009795987,-0.092859946,0.011077248,-0.06582208,0.030055253,0.0024249034,-0.03205906,0.033766013,-0.065664895,-0.013736617,-0.023016421,-0.03601505,0.06288963,0.029574653,-0.030341713,-0.0037706983,0.021587953,-0.03952117,0.057796236,-0.00016591513,-0.035862543,-0.056404904,0.084722556,0.005747302,0.029731987,-0.11334594,0.030142752,0.09848381,0.0066872765,-0.056202095,0.06307861,0.0047684964,0.036701873,-0.07107536,0.04450029,0.06157639,0.06491133,0.06727446,-0.0067457976,0.0661381,0.09814554,-0.00018910062,-0.06460719,0.012475369,-0.038041007,0.060750026,0.08801221,-0.005632103,0.0065872693,0.010619079,-0.016877918,-0.012236347,-0.022268187,0.003853487,0.03537493,0.016277516,0.013742433,-0.03039958,-0.057031758,-0.044252034,0.026444288,0.0024265808,-0.011766204,-0.09785864,-0.063066795,-0.014722148,-0.07049378,0.036055323,-0.08229892,-0.017880604,0.05399921,-0.035616644,0.0082434835,-0.051511806,0.093441926,0.121361315,0.0443318,-0.0028103562,0.01312667,-0.078124344,0.03171042,0.08128767,-0.013126368,-0.035612136,-0.047562458,-0.012065023,-0.059930068,0.008274245,0.06300092,0.042245727,0.012057009,-0.03281021,-0.017061451,0.013901017,-0.034638148,-0.06385818,-0.08022898,0.015282233,0.042586267,0.14533639,0.058926404,0.012681331,-0.063267276,0.0076028733,-0.027245414,-0.034489803,-0.031786393,0.0330759,0.08531312,-0.0820661,-0.08609822,-0.07186507,-0.056485515,-0.0014813977,0.04322224,0.03723807,-0.032475904,-0.05655815,-0.09820343,3.277358e-33,0.070885815,-0.01061063,-0.04594208,-0.033042215,-0.027063148,0.015713887,-0.11793231,-0.004342937,-0.025671942,-0.08210978,-0.00034156453,-0.006833129,-0.004068902,0.046049092,-0.013362763,-0.055458598,-0.034609314,-0.06088355,0.05994022,-0.033018216,-0.012668772,-0.02328587,-0.018157102,-0.06009606,-0.042774253,0.02324792,-0.0030473112,0.020463655,-0.0019006379,0.01601249,-0.04787958,-0.08829421,-0.10306266,0.003286632,-0.031043164,0.053435992,-0.068899795,-0.0109188,-0.02791368,0.07092399,0.014781265,0.041484512,0.004021457,-0.0976352,0.06969255,0.006447382,-0.039805867,0.13486351,0.023880903,0.023978619,0.03205397,0.051105317,0.0865673,-0.040599834,-0.07653557,0.004284716,0.042230505,0.0479059,0.009788638,0.03747686,-0.038754005,0.062430087,-0.008218463,0.08758485,-0.03552982,0.030352112,0.017636038,0.010225522,0.004191675,0.06996163,-0.03810361,-0.007078107,0.09969164,0.02241898,0.044384845,-0.015082185,-0.017633693,-0.040400226,0.071923025,-0.0067012305,-0.007609208,-0.031009715,-0.022409802,-0.022504898,0.0028244245,0.058133326,-0.011785405,-0.032840457,-0.042965982,0.051186327,0.04689076,-0.07151421,0.0086838715,0.039992943,0.046735734,-4.1521017e-33,0.06287773,-0.08663623,0.07066076,-0.099675335,0.024551041,0.03240335,0.055050205,0.005210455,0.049949467,-0.0007553037,0.07496579,-0.030926606,-0.012306442,-0.018320436,0.002656792,-0.009640987,0.013993217,0.062106207,0.031951733,-0.031623248,0.07317917,0.07261531,-0.028950369,-0.021839911,-0.0010014643,0.05610074,-0.018674368,0.059274115,0.06281795,0.07361481,-0.0025523782,0.006463889,-0.07884946,0.015427254,-0.042786743,0.08990476,-0.061457146,0.081077605,0.06335417,-0.025215428,0.03431593,-0.0074656964,-0.07549166,0.051416002,0.08181893,0.11708439,-0.10878737,0.05329954,-0.019477626,-0.02737288,0.0648995,-0.01378697,-0.050407287,0.0039845617,-0.00671994,0.06806051,0.05544319,-0.015336243,-0.010288395,-0.06201187,-0.04259127,0.011778235,0.023313727,-0.015955102,-0.077394694,0.077123016,0.028778784,0.055319883,-0.012795047,0.028873961,0.098965995,0.0237589,-0.009533356,0.07841265,0.010665773,0.010883599,-0.044042733,-0.007398246,-0.013168498,0.029163022,0.024493733,0.011423993,-0.038020354,-0.010701043,-0.036585223,-0.04853456,0.0084639685,0.033099603,0.0044170353,0.0509336,-0.04633477,0.047483258,-0.054881696,0.012903803,0.06409415,-3.736815e-08,-0.00028036188,-0.12272475,0.07318856,-0.03851205,0.04942067,0.044934064,-0.055014614,0.029324597,0.08016274,-0.06642701,0.016219838,0.048119325,-0.02047448,-0.040468197,0.023514636,-0.021609223,0.04478942,-0.00022353092,-0.016320243,-0.060232293,-0.05223345,0.036174007,-0.054258265,0.0076880297,-0.006260205,-0.08319073,0.022622788,-0.047674444,-0.028491883,-0.06371366,-0.01035281,0.05770242,-0.06519343,-0.049860276,-0.08563339,0.03491007,0.0033310088,-0.081599884,0.025963359,-0.035107225,-0.055393927,-0.024282323,-0.052135948,0.010029441,0.04026378,0.0045453575,-0.029528977,0.009744997,-0.04338119,-0.041791406,0.06625639,-0.06531056,0.07553294,-0.056718975,-0.09492686,0.07793507,-0.07781633,-0.09948566,-0.007284347,-0.10271442,0.024232958,0.024558604,0.19525267,-0.047447942 +1.14.13.241,"Contains FAD. The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine (vitamin B6). Although the enzyme was initially thought to be a dioxygenase, oxygen-tracer experiments have suggested that it is a monooxygenase, incorporating only one oxygen atom from molecular oxygen into the product. The second oxygen atom originates from a water molecule, which is regenerated during the reaction and thus does not show up in the reaction equation.",384,1.0,-0.10754709,-0.026822556,-0.08544966,0.00036555415,0.11796283,0.030383954,-0.030721216,0.052836485,-0.021476554,0.0052188537,-0.0057254685,-0.045868378,-0.05575426,0.040261403,-0.056222778,0.05062152,-0.11186665,-0.037415557,-0.023710594,-0.023011032,-0.011550943,0.052931484,-0.0050943857,0.017075151,0.061213467,0.022277622,0.0897685,0.040226627,-0.005450035,0.0035335189,0.024944501,-0.0021094854,0.060076784,-0.035196245,0.01492451,0.10341927,0.013093933,-0.03768181,0.013572675,0.0019039818,-0.030826572,0.043459456,-0.048703864,-0.045020144,0.015051817,-0.0052738483,0.043551013,0.029175922,0.03047576,0.01280231,-0.040876217,-0.05652083,-0.0916626,0.044948496,0.06252047,-0.004912345,-0.022426333,-0.08809384,-0.013981684,-0.009837492,1.0181349e-05,-0.04572535,0.04447148,0.040508524,0.035733204,-0.054391187,0.0006493121,-0.06805617,-0.03766051,-0.10728581,-0.053100422,-0.07103743,0.021025369,-0.020984389,-0.0187918,0.035522398,-0.07669612,-0.08029224,0.00407967,0.008561467,0.028174952,-0.051200584,0.043734856,0.1319005,0.0333971,-0.033751316,0.024963334,-0.07863767,-0.0056524845,0.004248821,0.031211035,0.037394695,0.020495648,-0.02921359,-0.037057422,0.05170077,0.052209225,0.06925425,0.038249634,-0.016865969,-0.09562347,0.066816516,-0.06078153,-0.054674454,-0.060394935,-0.05409744,-0.013541481,0.17671147,0.039930742,0.010784287,0.011551473,0.03509238,0.012099212,0.0034876075,0.05429962,0.06798834,0.01250667,-0.012287898,-0.06790747,0.07429588,0.003216972,0.019714354,0.09125092,0.007270163,0.008524213,-0.03969179,-0.038350675,1.8913844e-33,0.025777243,-0.0033244267,-0.022202572,0.003946113,0.0052518407,-0.0047995765,-0.09664975,0.014816454,-0.04240651,-0.049461897,-0.04828102,-0.025771514,0.048746057,0.010818893,-0.016882135,0.02016247,-0.04863941,-0.04833658,0.0497666,0.022322094,0.055889793,0.031577673,-0.027979644,0.03719265,-0.026029404,0.075383306,0.0534769,0.10595337,-0.010223517,-0.033277817,0.03797853,-0.032928515,-0.10669633,-0.01711655,0.038294546,-0.034109093,-0.058414064,0.0041992357,-0.13997662,0.05666292,0.01696541,-0.01301824,-0.043511372,-0.023558548,0.124336034,-0.09511048,-0.048096497,0.11776285,0.02554343,0.059643663,0.030128794,0.03281261,0.098223194,0.0043740226,-0.07058589,0.010088526,-0.006153687,-0.023014287,0.05095635,0.041061517,0.06371171,0.047896005,-0.02556119,0.08242775,-0.0075878436,0.029196074,-0.021018613,-0.07005378,0.0037009958,0.082959965,0.015304321,-0.011698568,0.06659494,0.0045524715,0.037382647,-0.050475106,-0.054336257,-0.011227986,-0.0038956548,-0.0755626,0.0098864855,-0.038264267,0.04745458,-0.009164587,-0.052007962,-0.018541448,-0.07373037,-0.10133132,0.016240729,0.023844045,0.06391107,-0.10856334,-0.09790153,-0.034698334,-0.008135968,-2.625156e-33,0.04569135,-0.051753953,0.028027687,-0.053190343,-0.019658579,0.07349723,0.056141064,0.037320316,0.01364334,-0.026991848,0.07987914,-0.003072313,-0.031628676,0.00896594,0.05874291,0.06101965,-0.021707386,0.045945365,0.04861887,0.021092704,0.015725382,0.04527886,-0.00082258385,-0.020004706,0.051104616,0.07524811,-0.0046122703,0.044619236,0.09440526,0.03777887,-0.015153182,0.019156478,-0.01367093,0.030950101,-0.057110272,0.052831598,-0.076547995,-0.046324905,0.026167296,0.05188533,0.016251775,-0.026503658,-0.022039963,0.042152338,0.042683158,0.016228758,-0.0778463,0.049806524,0.04816961,-0.08609366,0.017149618,0.02753187,-0.021399895,-0.046482228,0.03918364,0.052851573,-0.023678279,-0.013759152,0.012018156,0.0015912517,0.08398918,-0.10266506,0.063256934,0.10469904,0.010935508,0.058959343,0.009512473,0.07430367,-0.01085564,0.014189308,0.08814061,0.0017830055,0.00073448144,0.018131575,-0.013729461,-0.036017086,-0.063842244,0.019304875,-0.007194562,0.060204595,-0.004274751,-0.005925372,-0.008835281,-0.041451562,-0.061392125,-0.14742142,-0.010628222,0.033684235,-0.0025602109,0.016518723,-0.0015244647,0.0020934853,-0.056587197,-0.00019545264,0.08096348,-4.01763e-08,0.02962093,-0.10117654,0.096617974,-0.032538213,0.08344563,0.017940724,0.010387865,-0.013997568,0.037425555,-0.0020982127,-0.029549535,0.03886712,-0.030966485,-0.01332727,0.025603265,0.02534511,-0.03529529,-0.020508531,-0.04252107,-0.01714002,-0.059851076,-0.02137213,-0.023605172,0.0075662695,-0.012257934,-0.062030744,-0.041951194,0.012064704,-0.012519019,-0.033100132,-0.013072893,0.027249796,0.06058931,-0.065029524,-0.108085066,0.00579725,0.011497933,-0.049372397,-0.08166112,0.0135287335,-0.051253513,-0.031255066,-0.106790654,-0.004132082,0.055650126,0.039735865,-0.052790716,-0.053479675,-0.06463122,0.034838345,0.10694568,-0.0020338541,0.028216843,-0.038197704,-0.13197538,0.026757186,-0.033354495,-0.076299354,-0.049848117,-0.042056266,-0.0036545028,0.029724224,0.18798861,-0.02805106 +1.14.13.242,"Contains FAD. The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6). Although the enzyme was initially thought to be a dioxygenase, oxygen-tracer experiments have shown that it is a monooxygenase, incorporating only one oxygen atom from molecular oxygen. The second oxygen atom that is incorporated into the product originates from a water molecule, which is regenerated during the reaction and thus does not show up in the reaction equation.",384,1.0,-0.087772995,-0.027005631,-0.08001418,-0.010739719,0.11455835,0.020300837,-0.043181468,0.050430022,-0.006034204,-0.019230664,0.023008414,-0.015836366,-0.033971198,0.04661442,-0.08343983,0.097352766,-0.0880932,-0.0032027068,-0.037600953,0.033273984,0.034173384,0.10008958,-0.01767301,0.026598608,0.05267287,0.02975333,0.08718286,0.043745838,-0.007732764,0.004443426,0.0019562924,0.020259421,0.059185486,-0.06673724,0.04086239,0.09822802,0.00031016752,0.0011038048,0.019049162,-0.034830738,0.0147821205,0.023713129,0.0067024245,-0.049683545,0.015438124,-0.006522604,0.03963994,0.030008916,0.056664906,-0.0025275499,-0.08488762,-0.031200485,-0.04463641,0.034678414,0.026434762,0.025619313,-0.0069271387,-0.023691572,-0.048000194,-0.0033540982,-0.016009577,-0.060222723,0.04285583,0.023855401,0.06473864,-0.03436151,0.012452956,-0.052366707,-0.013624712,-0.10464476,-0.048030786,-0.070952974,0.06065127,-0.047014337,-0.029075248,0.050763365,-0.07473674,-0.07147558,0.01580705,0.035993323,0.01969025,-0.072831504,0.04683891,0.12016781,0.040167388,-0.019895304,0.017550379,-0.056353427,-0.007673872,0.0064935586,-0.007765443,0.020199107,-0.0110672405,-0.01836329,-0.03816483,0.049907174,0.042023234,0.08766624,0.046220798,-0.04072853,-0.07291191,0.015854804,-0.07372467,-0.042294733,-0.057877433,-0.04399682,0.017978529,0.12535045,0.052131124,0.033983663,0.012088815,0.020930588,-0.009096708,0.006177845,0.054900337,0.039950788,0.08154579,0.0088074375,-0.10238646,0.0502929,-0.010116717,0.012768469,0.09151603,-0.004216221,-0.00033428942,-0.032971483,-0.026001543,2.269725e-33,0.009633931,-0.015228743,-0.053943638,0.0028328847,0.020085732,-0.021041207,-0.092213966,-0.035565134,-0.04453477,-0.060889862,-0.04624444,0.011688207,-0.0063774977,0.014355496,-0.015567724,-0.020103673,-0.0143385315,-0.05618187,0.086850196,0.0021337776,0.06766502,0.039465938,-0.025058093,0.018721811,-0.013099191,0.061373837,0.098784946,0.063243575,-0.02737464,-0.03566256,0.034865033,-0.046011552,-0.16637366,-0.06682057,0.033563726,-0.036215782,-0.06691594,0.011076127,-0.09521077,0.03751804,-0.037762523,0.0076921633,-0.06319594,-0.017273743,0.09937808,-0.094780594,-0.050397076,0.1531135,0.04563824,0.046303138,0.0029282419,-0.038069878,0.092091285,0.009701733,-0.083507545,-0.039824106,-0.0068520945,-0.01993592,0.036106963,0.06979798,0.032263648,0.04309365,-0.020862611,0.11048565,-0.026980009,-0.006806858,-0.006111992,-0.039346475,0.034084942,0.07597139,0.009507868,0.020801043,0.04228597,0.015884444,0.0051841084,-0.07068066,-0.057751656,0.021203076,-0.0050233323,-0.0542927,0.044144917,-0.049174603,0.026461655,-0.0016026322,-0.07737583,0.05663068,-0.058044422,-0.07303543,0.030722585,0.0060786395,0.08204869,-0.111052096,-0.05045497,-0.023623735,-0.007514734,-2.9415732e-33,0.033062648,-0.030274732,0.073211744,-0.050054416,-0.01470773,0.05164673,0.05005582,0.054259382,0.027854921,-0.04569481,0.013247322,-0.0024575698,-0.028041257,0.005517873,0.017391654,0.0530874,-0.0063629104,0.02265965,0.06466788,-0.03389454,0.013793702,0.04173894,-0.054183193,-0.030365823,0.033713188,0.06918666,-0.006306314,0.055362925,0.05343054,0.04953752,-0.006783513,0.07385193,-0.041694276,0.00870041,-0.026490575,0.07013827,-0.08045826,-0.018163964,0.015508193,0.04515145,0.005048102,-0.022394953,-0.020438604,0.05479217,0.013064773,0.03456627,-0.0841885,0.021388311,0.04949459,-0.102693155,0.012726257,0.027178692,-0.0021340027,-0.020729406,0.04689744,0.015221036,-0.009715596,-0.026111273,-0.036216132,-0.01637342,0.066428535,-0.11651153,0.030001892,0.07230783,0.00073507504,0.08533597,0.03893217,0.037442554,-0.01606866,0.048675384,0.117273785,0.014288892,0.014711546,0.039469175,-0.033431634,0.008147171,-0.050761454,0.036907643,0.013255934,0.03608575,0.03509765,0.012330255,-0.03931031,-0.06889227,-0.034004614,-0.13172314,0.040472418,0.059756424,-0.043181397,0.009863674,0.00248035,0.012318891,-0.06751959,-0.01958641,0.040710125,-4.362812e-08,0.06486987,-0.1282716,0.06677241,-0.029026993,0.039947707,0.014568441,0.014553306,0.04087707,0.07202891,-0.014139698,-0.040282365,0.050942138,-0.044877015,-0.032341342,0.03548476,0.02206919,-0.0647753,-0.021756403,-0.04289174,-0.03714822,-0.056535006,-0.019338338,-0.083585,-0.0030231678,-0.019268002,-0.033409957,-0.030515172,0.0054376493,0.0057730707,-0.023493042,0.012996516,0.026679803,0.056067456,-0.07126005,-0.119140685,0.0046560266,0.0115857525,-0.030751199,-0.07087309,-0.0016639227,-0.05419992,-0.049644202,-0.079304904,-0.007943489,0.05707702,0.039757356,-0.05482138,-0.057288077,-0.05489366,0.022335667,0.098889284,-0.008430273,0.035317156,-0.009289306,-0.17090462,0.037178233,0.0033085241,-0.054977078,-0.047945336,-0.05191455,-0.0040326347,0.0067147925,0.18645647,-0.02617617 +1.14.14.73,"This is one of the activities carried out by some microsomal cytochrome P-450 monooxygenases. A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32, albendazole monooxygenase (flavin-containing)), but it is estimated that cytochrome P-450s are responsible for 70% of the activity.",384,1.0,-0.049836177,-0.015606542,-0.08298454,0.008440025,0.06406634,0.04090786,-0.0062687346,0.07156196,-0.023237588,0.0072992663,0.003720396,0.0042970856,-0.039214164,0.06579094,-0.03046871,0.06850234,-0.048642587,-0.03900794,-0.03680578,-0.022039326,-0.0023120376,-0.012664666,0.10193362,-0.020801628,-0.0420869,0.018645227,0.00913443,0.030504325,0.0006662837,-0.02487127,0.040055025,0.057081494,0.055246845,-0.031238684,-0.030621087,0.08373608,-0.08192989,-0.064834,0.021949515,0.0014196523,0.080682494,-0.018693916,-0.02007853,0.025751645,0.0064795953,-0.073509894,-0.01976173,0.04502845,0.0021614654,0.044477534,-0.0124462815,-0.03144564,-0.04702198,0.048654553,-0.01690344,-0.028741691,0.00662853,-0.06060229,-0.044436038,-0.007605522,-0.097201556,0.060630295,-0.024828069,0.061662726,0.0019006036,-0.008728597,0.009042969,-0.094234355,-0.01089754,-0.07285844,-0.012072271,-0.080795914,-0.016940778,-0.02920272,-0.089437455,0.019180248,0.006723092,-0.033946086,-0.037474617,0.002974122,-0.009983619,0.016060216,0.028659003,0.04521391,0.043108065,-0.015115485,-0.059482176,0.07125246,-0.06223785,0.059876963,-0.038068682,0.009025246,-0.0045302035,0.0038430449,-0.050444555,0.025336385,0.03286061,0.03345773,-0.005836061,-0.0462339,0.003717376,0.04035508,0.023054214,-0.024678132,-0.052169133,-0.035633843,0.014104599,0.08563642,0.0022247953,-0.07579639,-0.03089179,-0.04780335,0.046845604,-0.022871232,0.043513734,0.050823938,0.023055557,-0.043049634,-0.027364206,0.09780033,-0.04000299,-0.00849481,0.058704186,0.016863704,-0.017827595,0.048591323,-0.061759174,2.8029903e-33,0.05783197,-0.05247379,-0.017912785,0.028148627,-0.008019694,0.0726571,-0.029837254,0.015439875,-0.00913421,-0.045737725,-0.05735115,0.024000248,0.085532546,0.056243733,-0.04133812,-0.034209017,-0.016281242,0.0045136525,0.07237331,0.0018855233,-0.043375675,-0.019890124,-0.0630454,0.02880763,0.0063479263,0.13810864,-0.06870135,0.0343686,-0.026153412,0.010367804,0.0077264924,-0.06795089,-0.08892657,-0.04941869,-0.011058477,0.060296174,-0.007419161,-0.0074875266,-0.07057258,0.06850768,-0.0489961,-0.09234512,-0.007506402,-0.053809777,0.034358364,-0.040351838,-0.1478658,0.09539686,0.013804658,0.051440027,0.07847844,-0.026909651,0.08217077,0.026597513,-0.09156852,0.08284464,-0.02624719,-0.0651572,0.021401823,0.0705944,0.09809236,0.014688794,-0.0222475,0.06564846,0.039786573,0.030920574,0.019333089,-0.060555458,-0.06777453,0.123426765,-0.024035107,-0.0223893,0.08774471,0.0031156982,0.07028388,0.034605153,0.044452723,0.061553784,0.0033126331,0.03364783,0.0045177094,-0.025676407,0.009765759,-0.06924803,-0.015316861,0.036525004,-0.016606212,-0.06959847,-0.03279251,0.04004688,0.10324408,-0.15304326,-0.016424121,-0.036760192,0.0012457141,-5.038454e-33,0.028581426,-0.03915412,-0.062190875,-0.14322214,-0.059766084,0.082122415,0.031668115,0.0038445715,-0.022913743,0.07715668,0.029551191,-0.06131558,-0.006254926,-0.076794155,-0.03337157,-0.005586071,0.0024625452,0.07437806,0.056649067,0.033751212,0.024108596,0.014645124,0.06913065,0.028730502,0.02983712,-0.0058666826,-0.025836874,-0.019951433,0.059729587,0.011191957,-0.1342479,0.07530213,-0.092878394,-0.040684838,0.0019106216,0.0130376965,-0.043564476,0.04463735,-0.002146828,-0.022669725,-0.012420227,0.059271187,0.01518263,0.065377906,0.023305638,0.15320969,-0.11569635,-0.08519104,-0.043550048,-0.07953245,0.0010655066,0.096551955,-0.015573822,0.0650977,0.0015732435,0.07413302,0.005406897,-0.024959944,0.056100536,-0.053778145,0.017564392,-0.031382754,-0.033992875,0.029468102,0.02866148,0.06230974,-0.0057977405,0.063147776,-0.010070043,-0.0006830933,0.037252203,-0.037495255,0.06600614,0.060662787,-0.076422,0.016752996,-0.02421813,-0.055793818,0.039115734,-0.02291039,0.06797076,-0.023174621,-0.023287775,-0.07114506,-0.07478177,-0.13935965,-0.024424206,0.045697797,0.027916154,-0.032139953,-0.02447642,0.023902863,-0.10602326,-0.050203368,0.028609304,-4.08311e-08,-0.03301351,-0.014791321,0.05392631,0.013341763,0.02152973,0.08936957,0.021565922,0.049547702,0.030984415,-0.044237174,0.023524024,0.017609706,0.03255121,0.03331554,0.028305339,0.016634263,0.002056567,0.0024415613,0.04253386,-0.046218377,-0.07514486,-0.0038921584,0.016253317,0.05236658,0.017988268,-0.043392017,-0.039024528,0.08272681,0.048366606,-0.059903234,-0.06586066,0.025258208,-0.036426976,-0.011420517,-0.044317637,0.005694833,0.0046494645,-0.033928968,-0.06434435,0.047260668,-0.098260395,-0.13667546,-0.025724743,-0.0032834609,0.0065754205,0.0016094372,0.043016016,0.03601979,0.024097495,-0.022057066,0.040124662,-0.017882377,-0.018806806,-0.04317264,-0.097229175,0.018049676,0.046555247,-0.09982269,-0.023543384,-0.070819676,-0.040789668,0.04697193,0.12387518,-0.032363623 +1.14.14.74,"CYP2J2 is a microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the terminal carbon of the propylsulfanyl chain in albendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. cf. EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming).",384,1.0,-0.06559494,0.080633506,-0.018198112,-0.014985118,-0.025167644,0.0476551,-0.052094202,0.07179027,-0.033471987,-0.0071635614,0.051326383,-0.017500713,0.0034002897,0.055261984,-0.064157955,0.09221444,0.094567314,0.032344338,0.05516212,-0.06519872,-0.01556245,0.059116807,0.0772459,-0.09337819,-0.013246946,0.08864818,0.010834602,0.054203417,-0.021706382,0.012729108,0.04219762,0.027397582,-0.014737766,-0.04296978,0.016433412,-0.005616855,-0.008988937,0.0198899,-0.001314454,0.029894933,0.045869403,0.038874753,-0.049561992,0.058649372,-0.0067617907,-0.06607176,-0.03186709,0.017251952,0.005056342,-0.086580984,-0.05743109,-0.028842097,0.012122761,0.059934765,0.03417435,-0.018328257,-0.03618884,-0.0136345895,-0.050410923,-0.056415536,-0.025139812,0.033457622,-0.018440682,0.037375826,-0.01046508,-0.07511022,-0.0216171,-0.03655833,0.008596193,0.017004607,-0.092445076,-0.06651733,0.016228769,-0.02122738,-0.075299546,0.010719781,-0.00848763,-0.07961896,0.039721224,0.005384124,-0.023445392,-0.013690064,0.021614755,0.019382734,0.006418698,0.01288976,0.04870981,0.046963006,-0.019659827,0.055642284,-0.0028615354,0.013758256,0.058000762,0.038227044,-0.0909526,0.028169192,0.07250156,0.070566416,0.011552,-0.015307299,0.041240282,0.028490106,-0.00048929785,-0.090980485,-0.018037222,-0.046879716,-0.03368867,0.099414,0.08221722,-0.028625496,-0.05454943,-0.023891708,-0.05756658,-0.012110945,0.07977974,0.08462334,0.06677037,-0.0039305566,-0.010966301,0.009995443,0.014359219,-0.017987844,-0.072836146,0.00268395,-0.012701086,0.060182348,-0.120503806,4.0518835e-33,0.0138181755,-0.007874246,0.035691574,0.04344635,-0.025689406,-0.024425223,-0.08962483,-0.013329398,-0.036504276,-0.029988566,-0.09831655,-0.045268316,0.018577056,0.03999482,-0.063938856,-0.032604206,-0.038605597,0.017170612,0.12136507,-0.0028506026,-0.021630289,-0.00606184,-0.020018985,-0.045738384,0.044077236,0.09295056,0.016811995,-0.014641735,0.013075704,0.028828494,0.02095326,-0.08872094,-0.10909104,0.0039942088,-0.0089997,0.007356339,-0.0080312705,-0.07552036,-0.066278756,-0.041665886,-0.084705986,-0.04211505,0.05562338,-0.032702867,0.022606563,-0.075869836,-0.114946075,0.06897027,0.04650082,0.06082256,0.106200635,0.006118911,0.1027858,0.038909655,-0.038878795,0.087371945,-0.010027988,0.03505074,-0.0032669108,0.05895157,0.00044519984,0.022320723,-0.07662787,0.042972013,0.046297923,0.014023893,-0.05879334,-0.062288515,-0.07577073,0.14536788,-0.031593997,0.0053137843,0.10925519,0.04613036,0.028646613,-0.03212312,0.025217604,0.014650315,0.06118605,0.06782005,-0.06515815,-0.065261476,0.010797245,-0.06308256,-0.0035588483,-0.010287651,-0.041996904,0.0020062132,0.029579958,0.12018536,0.072346285,-0.03980236,-0.051154636,0.012933693,0.02450676,-5.2560724e-33,0.049204253,0.0074518416,-0.05930206,-0.085806884,-0.0023782903,-0.006185922,0.0044527,-0.006737112,-0.016577074,0.011293408,0.020079311,-0.0072983135,0.11809158,0.013283966,0.016898466,-0.07248063,0.033038534,0.03278581,0.013896325,0.0039864248,0.013519755,0.04864466,0.018300468,0.0063499794,0.00880179,-0.03377019,0.04032088,0.040503893,-0.03303439,0.04418141,-0.037198678,0.06422054,-0.07185216,-0.061897647,0.04491543,0.04619756,-0.07878956,0.010329441,-0.015671713,0.004846778,-0.08288568,0.047696564,-0.075066335,0.1362414,-0.0027065387,0.048479136,-0.032887567,0.020911736,0.03848259,-0.07708633,-0.063371055,0.09414561,-0.015938658,0.028309964,0.016881982,0.056585,-0.104958005,-0.021098785,0.094811484,-0.029049372,-0.019132214,-0.038257085,-0.017519616,0.027164256,0.023902189,0.02536417,-0.0122048855,0.04558356,-0.03896396,-0.014697594,0.07761277,0.019813636,-0.0035680465,0.048413478,-0.06627631,-0.04776799,0.011767917,0.008379473,-0.01697482,0.0301244,0.15104045,0.005154989,0.048002023,-0.008005024,-0.031617284,-0.15204678,-0.041640095,0.14805424,-0.09780817,-0.08140377,0.019683292,0.05368351,-0.106174126,0.101291366,0.011584942,-4.0037545e-08,-0.068164535,-0.030771894,0.078338034,-0.06263714,-0.014968876,0.04022984,-0.020386424,0.0035407655,0.0616511,-0.017590962,0.027801156,0.07500314,0.012922889,0.05188546,-0.0041050655,0.05163663,-0.02696617,-0.038514487,0.014703736,-0.025546852,-0.08682473,-0.017870896,-0.060927916,0.060884785,-0.01797708,-0.037622273,0.015254396,0.036399055,0.057168394,-0.05688247,-0.054254387,0.061549652,-0.025631063,0.02218714,-0.044543926,0.024076698,-0.049545713,-0.032964546,0.022640692,-0.0139104305,-0.0367379,-0.018139336,-0.0021316258,-0.016081037,-0.007974039,0.019269748,0.025340289,0.029684259,-0.057306442,-0.08692962,-0.005892849,-0.010442384,-0.0014047531,-0.07726447,-0.051273394,0.02417046,0.0027903845,-0.050198212,-0.062490735,-0.04597267,-0.003332237,0.03511156,0.124675974,-0.01984038 +1.14.14.75,"CYP2C19 is microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the benzene ring of fenbendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. This activity is also carried out by CYP2J2. cf. EC 1.14.14.74, albendazole monooxygenase (hydroxylating). CYP2C19 does not act on albendazole.",384,0.99999994,-0.08400192,0.011455993,-0.06560142,-0.03320981,0.009477582,0.04993235,-0.04064126,0.04716755,-0.03436097,-0.036095984,0.02462388,-0.03008478,0.0064420463,0.076126136,-0.11419019,0.054607686,0.07665957,-0.0035561803,0.06891561,-0.043852437,-0.06983616,0.09126983,0.11673301,-0.051091474,-0.06771824,0.016799457,-0.008684328,0.04321801,-0.033819567,0.0057055037,0.14538601,0.044503924,-0.034188785,-0.038177896,0.013643233,-0.04807608,-0.02962451,-0.02311193,0.023922976,0.02597515,0.04142138,0.019317642,-0.086893044,0.01420503,-0.027416855,-0.07478478,-0.030001687,-0.027008532,-0.009998107,-0.049897414,0.0027898236,-0.03494597,-0.037684917,0.0909379,-0.012282621,0.021955073,-0.03987159,-0.007847922,-0.015367769,-0.0075036,-0.03237554,0.05671732,-0.03151758,0.05539959,-0.023481628,-0.02115581,-0.03066187,-0.021369098,-0.02567919,-0.023055803,-0.080933265,-0.08418604,0.057914566,-0.078045644,-0.094908535,0.0071425764,-0.014964902,-0.07976148,-0.018006522,0.012845576,-0.05969878,-0.029752715,0.038541038,0.05235596,0.05969392,0.008725331,0.07634804,0.06278435,-0.0062617958,0.05700014,0.0142851295,0.051684894,0.074721076,0.061089035,-0.06575917,0.007860747,0.09870503,0.07146016,-0.006456861,-0.02523909,0.041153464,0.029414918,0.01777455,-0.08278971,0.0047412133,-0.041659724,0.023624556,0.10680589,0.08962998,-0.018010564,-0.091309026,-0.0017767686,-0.05082979,-0.017965231,0.028378721,0.068608336,-0.0036382815,-0.032731228,0.0028677261,-0.00074364844,0.021473952,-0.071854405,-0.02667986,-0.018514177,0.0180273,0.07103952,-0.095225096,4.7719325e-33,0.0031929235,-0.013425013,0.0050368975,0.033691335,-0.004590562,0.03426878,-0.088207535,0.005638094,-0.03328044,-0.06501151,-0.073419176,-0.0064191483,0.016426928,0.039530665,-0.0635749,0.00038714125,-0.04708284,0.006825588,0.09269333,0.010161473,0.021813912,-0.021463133,-0.025260605,-0.06651451,0.022717927,0.05240335,-0.07427127,0.044473644,0.02420431,0.019699108,-0.032197308,-0.08020634,-0.061557394,0.0058583333,0.010519165,0.079365626,0.01354065,-0.08263324,-0.05062407,-0.011397573,-0.06302761,-0.08274951,0.04760261,-0.06314027,0.084784865,-0.06694548,-0.078112125,0.116446145,-0.0017586624,0.03775678,0.11523423,-0.051150735,0.062505096,0.06724431,-0.008422273,0.08341286,-0.071481094,0.030531695,0.02121188,0.07002955,0.062217213,-0.0032543896,-0.055507593,0.03995463,0.09586882,-0.027805645,-0.016912786,0.019868627,-0.08472089,0.105771564,-0.06273668,-0.024998222,0.10054065,0.06525343,0.06541481,-0.031672344,0.039411105,-0.012826629,0.061097704,0.049242944,-0.0023709468,-0.064215094,0.00970636,-0.061955664,-0.01171731,0.018334297,-0.035988882,0.014671352,0.011637057,0.07846151,0.08109991,-0.13115594,-0.028882394,0.013670894,0.020097,-5.427635e-33,0.08234244,0.0018384013,-0.06791949,-0.08940842,0.03148146,-0.010083929,0.053624645,-0.024185738,-0.003677716,0.008768898,0.031539362,-0.04172359,0.063634545,-0.057014283,-0.0036211528,-0.08804858,0.030324295,0.006731769,0.021951001,-0.0154429795,-0.041698385,-0.0014001592,-0.023592122,-0.008202044,-0.048245624,0.014831597,0.054495506,0.0151520055,-0.028254896,0.031895503,-0.100189626,0.07392434,-0.073807225,-0.023571568,0.053218815,0.0615381,-0.084930085,-0.017372603,0.011223635,-0.034720708,-0.05082276,0.035473485,-0.090937845,0.11298585,0.032022063,0.05516394,-0.05259939,0.0051796623,0.04500489,-0.033026,-0.051642053,0.07679697,-0.0041535697,0.03713377,0.020462712,0.044024333,-0.017873963,-0.045072336,0.09699959,-0.042485714,0.03155231,0.047494736,-0.006842144,0.03814411,0.0069472836,-0.003341253,-0.054235455,0.08841693,-0.0053674793,0.04609071,0.04711434,-0.0010608367,-0.029453347,0.0344504,-0.11201123,-0.026147394,0.04122528,-0.0008271135,0.0036919003,-0.009637024,0.18102251,0.007897167,0.062017005,-0.048046783,-0.03547959,-0.09216974,-0.057921268,0.06797351,-0.046055634,-0.085969195,0.023791848,0.033986706,-0.04299807,0.06013108,0.03467466,-3.8279428e-08,-0.018708603,-0.015098236,0.048135012,-0.052698433,-0.0040845447,0.025139246,-0.0019056486,-0.013246652,0.029168643,-0.020792888,0.026962446,0.035468083,0.0073082675,0.028626604,0.013652774,0.06276987,-0.010381077,-0.021468876,0.018820303,-0.00768906,-0.111597165,0.030583711,-0.048612475,0.05643243,-0.037022043,-0.05732942,0.028120399,0.08147401,0.06930085,-0.043778233,-0.066330716,-0.015961671,-0.02345734,0.0008175593,0.018018743,0.03680298,-0.03704373,-0.045438617,0.014792859,-0.02593995,-0.0065543153,-0.03929389,-0.010525546,-0.050045222,0.027009381,0.009471486,-0.01253743,0.04489626,-0.018432278,-0.009510875,-0.010825563,-0.0061958446,0.013725871,-0.083429284,-0.03371811,0.035008453,-0.014819929,-0.06048093,-0.07510299,-0.05341868,-0.052667953,0.046128336,0.10907625,0.007820732 +1.14.14.76,This cytochrome P-450 (heme thiolate) enzyme has been characterized from the plant Oryza sativa (rice). It may be involved in production of oryzadione.,384,1.0,-0.09479185,0.025900953,-0.048995968,-0.0152056785,0.011657093,0.07388828,-0.041261755,0.069907226,-0.04847089,0.0035216429,0.07114976,-0.00497852,-0.006183486,0.030179735,-0.044298142,0.054025456,-0.0032045648,0.0023898075,-0.07445077,-0.09133548,0.021801522,0.06588603,0.03154501,0.035442937,0.009358168,-0.033419207,0.0060830885,0.07328303,0.001700349,-0.06106658,-0.0678402,0.023551162,0.03346533,-0.010913311,0.04584355,0.045139823,-0.034074146,-0.07417671,-2.1334046e-05,-0.034007557,0.08337477,-0.05917362,-0.08481778,0.0042662574,-0.042859357,-0.08349831,-0.010346457,-0.033447616,0.01951288,-0.05323825,-0.017156282,-0.02505349,-0.043212168,0.023515455,-0.09419871,-0.019875506,0.051580355,0.00818189,-0.0771803,0.01913329,-0.038755022,0.055787876,-0.056861978,0.048308976,-0.028460067,0.020643784,-0.04894524,-0.03558466,-0.0074335416,-0.072668575,0.022283696,-0.111620225,-0.033717114,0.07480942,-0.09131469,-0.004694918,0.046632092,0.013633398,-0.0012164564,-0.049514398,0.039607752,0.015031223,-0.0041437685,0.09547538,-0.0127072465,0.017736616,-0.07612131,0.1202156,0.0335691,-0.07065968,0.017002264,0.032008585,-0.045257553,-0.019024974,-0.0832359,0.08045356,-0.0038028308,-0.035664357,0.037332434,-0.031071277,0.0696587,0.05453906,-0.052495945,-0.10213075,-0.05253722,0.01455368,0.0027467576,-0.006869095,0.03779922,-0.044665176,-0.035494022,-0.038590334,0.011016967,0.024734685,-0.056177296,0.064042024,-0.023892382,-8.3232764e-05,-0.004946701,-0.07557511,0.0022872437,-0.026583666,-0.013296505,0.038277272,-0.014945194,0.02414681,-0.08760991,1.7373305e-33,0.06690404,0.05201439,0.031927496,-0.04091308,-0.004095651,0.026012352,-0.010550605,0.026851669,-0.05443742,-0.023285283,-0.10326807,-0.09928525,-0.029470855,-0.026122542,-0.0028593242,-0.025100753,-0.061349224,0.05138161,0.022992397,0.056227002,-0.027049787,0.022090618,-0.09919977,0.0017818534,0.01795613,0.07973211,0.018131573,-0.02151911,-0.00858947,-0.02355089,0.016457267,-0.04612428,-0.057806693,-0.074552335,-0.030025288,-0.033705812,0.00054134603,0.027070343,-0.047175433,0.07400495,-0.014909746,0.023828346,0.03857144,-0.050659,0.047296546,0.0025351006,-0.114754066,0.081373945,0.005967223,0.05796351,0.0338055,-0.04656861,0.09328496,0.07844958,-0.021260304,0.016158415,0.027562324,0.044087514,0.02041187,0.023498053,0.10021167,0.027006077,-0.040726982,0.061699226,0.030675314,0.0123225385,-0.07770465,-0.04191861,0.007659169,0.12920868,-0.058739062,-0.051531557,-0.008323901,-0.01334435,0.04927325,-0.041876443,-0.021964941,0.0558209,0.053559944,0.033328336,0.018786581,-0.021487907,0.020225797,-0.012420304,-0.03531423,0.009656984,-0.006584079,0.04853571,-0.048891716,0.040771555,0.08790276,-0.03604377,0.028207438,0.016717158,-0.011839198,-2.2332525e-33,0.061552882,-0.03731082,0.03096859,-0.06284895,-0.008879332,-0.012603167,-0.019288028,0.031988367,0.04183146,0.037724327,0.097953774,-0.023195725,0.04335516,-0.0438893,-0.022734074,0.05585271,0.00508785,0.07831909,-0.028860645,0.06072329,-0.077113084,0.054258585,0.005215622,-0.015032939,0.03556208,0.015209633,0.032537356,0.037724286,-0.0018586173,0.047501113,-0.007702153,-0.003453873,-0.085171424,-0.03559822,0.0028683462,0.03483349,0.027884308,-0.039181173,0.033245888,0.045829933,-0.07625355,0.11517389,0.06089823,0.055805467,-0.022426696,0.07120175,-0.1036954,-0.028020956,-0.032596163,-0.029822847,-0.007836049,-0.0013444619,0.0055313325,0.025225392,-0.032443624,0.0073856493,-0.017777396,-0.012396728,-0.09141165,-0.09391107,0.022998257,-0.020620126,-0.0055960976,0.0372177,-0.0064026117,0.12111542,-0.027724456,0.040696155,0.005828395,0.009584737,-0.010098399,-0.014855536,0.0021429907,0.11230854,-0.04272835,0.019640451,-0.020061268,-0.048189424,0.041034427,0.0154808415,0.008497334,0.007883941,-0.09190216,-0.0643907,-0.016408386,-0.068296105,-0.076216,0.16637187,0.09089637,0.0013652869,-0.0046372153,0.033613306,-0.051530413,0.07851126,0.07611074,-3.0576405e-08,-0.002641927,-0.17429024,0.02043191,-0.014445609,-0.010809036,-0.044721365,0.034775987,-0.0022178285,0.12147554,-0.034305997,-0.05158366,0.072246954,-0.05230958,0.014048278,0.01145943,-0.0007917124,0.09896682,0.07062001,0.03563258,-0.023032118,0.004899906,-0.02482999,-0.04134211,0.02367094,0.041948434,-0.023667624,-0.03731143,0.018995443,0.085902244,-0.010013203,0.0041624354,0.02423787,-0.009264717,-0.026044216,0.04055393,0.0949364,-0.015651904,-0.058938295,0.0052876053,-0.04615579,0.0008116666,-0.07637327,-0.0067005977,-0.02730049,0.032015357,-0.054396566,0.07646041,0.02081717,0.035460997,-0.060660724,-0.046562184,-0.032523073,0.043169696,-0.12486208,-0.07464636,0.018460507,0.065079264,-0.005380501,-0.028399918,-0.06729407,0.030814124,0.05150415,0.21620809,-0.02265894 +1.14.14.77,"The enzyme has been characterized from the cyanogenic millipede Chamberlinius hualienensis. Unlike plant enzymes that can catalyse this reaction (EC 1.14.14.44, phenylacetaldehyde oxime monooxygenase), this enzyme cannot act on phenylacetaldehyde oximes. It can accept (4-hydroxyphenyl)acetonitrile, (2-methylphenyl)acetonitrile, and (3-methylphenyl)acetonitrile as substrates at a lower rate.",384,1.0,-0.059328075,-0.059387337,-0.006544393,-0.004135382,0.0886096,0.010882953,-0.086807586,-0.04327429,-0.045227166,-0.009274401,0.06393149,-0.08634732,-0.094326004,0.040029667,-0.1294233,0.09639956,-0.08198337,0.026405869,0.038058717,0.010924702,0.0024124177,0.010249122,-0.001098349,-0.020856539,0.029108234,-0.018574892,-0.050311606,0.024925865,-0.017327707,-0.016919047,0.027487492,0.03564909,0.05197946,-0.032777164,0.111016884,-0.015452516,0.020578498,-0.097684465,0.04345998,0.038150154,0.06350112,-0.019522114,0.020855097,-0.06122833,-0.0036423723,-0.033844236,0.031080961,-0.032059003,0.0034578524,0.0020253127,0.0062017622,-0.07213032,-0.019197088,0.016748486,-0.019233612,-0.067895375,-0.015385525,0.004296443,0.0131613,0.033780307,0.029828085,0.055253986,-0.09691797,0.019284328,-0.018721502,-0.09442984,-0.07067272,-0.08224571,0.07661531,-0.05909384,-0.004557908,-0.108221255,-0.020214397,0.029961148,-0.028824035,0.018842129,0.028529007,0.014301454,0.057469655,-0.014758866,-0.071723826,-0.015273904,0.049678802,0.0027199597,0.083369605,-0.019600062,-0.047128018,0.11225682,0.049880374,-0.020009806,-0.04087645,0.07297926,-0.08260078,0.023144322,-0.0034309933,0.04651475,0.1209943,0.04765137,-0.06196152,0.038943656,-0.059542745,0.05131015,-0.09630892,-0.110400096,-0.014737628,-0.02784198,0.018019944,0.018474953,0.0119864335,-0.012810067,0.014745209,0.012163424,0.011127531,0.0059762057,-0.024288375,0.04473772,-0.0547783,-0.08194787,-0.022611795,-0.0060953223,-0.031289466,-0.009029564,0.034597605,0.08155972,0.024075288,0.023681942,-0.035546795,5.661316e-33,0.07203106,-0.04605946,-0.047985062,-0.059702497,0.082234606,-0.024177818,-0.017605457,0.038822364,0.031860597,-0.093071096,-0.033020455,-0.077218235,0.024880184,-0.020328702,0.00598397,0.037556164,-0.0689615,-0.04790896,0.10434636,0.020825123,0.014533475,-0.062086083,-0.07992446,0.07462577,0.029322647,-0.024974264,-0.04526952,-0.0081865825,0.08622883,0.022362348,-0.010571058,-0.11908142,-0.026426798,-0.017511994,-0.0664497,0.034962006,-0.025207983,-0.07929651,-0.008385982,0.07636017,-0.020749118,-0.013766933,0.050998993,-0.0452074,-0.018911123,-0.016586723,-0.055537373,0.06642311,0.0512953,0.033603486,0.019140491,-0.021696677,0.120618545,0.020839216,-0.07307827,0.061565913,-0.03596651,0.008643624,0.035532825,-3.976884e-06,0.010219409,0.030039914,0.05127089,0.041035585,0.03197019,0.024426974,-0.027635163,0.024500445,0.037286635,0.13272601,-0.09095822,-0.104331866,0.052175257,-0.0085171275,0.053386554,-0.059604146,0.038798068,0.030922407,0.009861172,0.015805911,0.014808228,-0.013933767,0.018675003,-0.04535581,0.004780237,-0.0171281,-0.06671947,0.024630941,0.06163787,0.0680014,0.0253988,-0.030585486,-0.028944435,0.03369852,-0.04845465,-5.7527202e-33,0.031563513,-0.03170546,-0.027545588,-0.041233294,-0.12370217,0.051953875,-0.04022058,0.043248277,0.02542211,-0.029311482,0.05132004,0.04523623,0.06865783,-0.04012526,-0.054927155,0.04856741,0.045561206,0.080145374,0.050140828,0.021120604,-0.000957932,0.066971086,-0.021396525,-0.000316213,0.009014948,-0.0047884113,-0.022439262,-0.009701678,0.041724175,0.014896418,-0.052046426,-0.004411662,-0.020591108,-0.040503047,0.015180061,0.059701413,-0.061525337,-0.09594002,0.019977149,0.12059184,0.018603226,-0.022839315,-0.06413805,0.09370418,0.03226178,0.021574274,-0.0725049,0.011627541,-0.040785167,-0.031014204,0.00615939,0.08158994,-0.05002207,0.015410279,0.0043818816,0.047595512,0.06994877,-0.027598843,-0.0113189425,-0.052475743,-0.031008316,-0.044189453,-0.02457478,-0.011435768,0.03442529,0.11710966,-0.038986474,0.11635137,0.01862673,0.012403859,0.061662927,0.02645357,0.060800266,0.102585234,-0.024842542,-0.055349495,0.07342921,-0.02336391,-0.015413136,-0.07799933,0.049839415,0.009049052,0.055306446,-0.059349783,-0.034292664,0.0021633136,-0.024405463,0.13006826,-0.0074440795,0.00026405207,0.033626825,-0.020507785,-0.03845531,0.055955507,0.09230653,-4.856923e-08,-0.027374176,-0.058376785,0.04636266,-0.032451965,-0.0732162,0.011083675,0.042942494,0.015092411,0.04568362,-0.044950984,0.06883388,0.039009966,-0.023637665,0.01720428,0.03110147,-0.00441047,-0.017402535,0.01988521,-0.042442366,0.047851685,-0.06702685,0.023957623,-0.044468474,0.044154216,-0.07191498,-0.019586885,-0.005412263,0.076264024,-0.06751254,-0.009592026,-0.009496923,0.030345878,-0.03546753,0.0133609995,-0.101617396,0.025106046,-0.01302292,-0.06306953,-0.00204817,-0.034511827,-0.02555641,-0.071666464,-0.05363398,-0.028806815,0.00578269,0.0120139755,0.030038588,-0.00340456,0.0443397,0.030325858,0.048530735,0.011549094,0.05780509,-0.07238273,-0.017863078,0.004966711,-0.009673773,-0.08555541,-0.035144277,-0.06987822,-0.0023667202,0.025483238,0.22165176,-0.030117387 +1.14.14.78,"A cytochrome P-450 (heme-thiolate) protein. Isolated from human tissue. The enzyme will also act on menaquinone-4. Prolonged action of CYP4F2, but not CYP4F11, on the omega hydroxyl group oxidizes it to the corresponding carboxylic acid. CYP4F2 also oxidizes leukotriene B4; see EC 1.14.14.94, leukotriene-B4 20-monooxygenase [1].",384,1.0,-0.046675585,0.032061454,-0.036003083,-0.033495598,0.05303078,0.0850197,-0.0577053,0.066009,-0.005946002,-0.031588413,-0.024057075,0.022485793,-0.021167938,0.07175964,-0.03730964,0.04647985,-0.022677364,0.053055666,-0.01555216,-0.072225526,-0.03447259,0.0061565056,-0.0077913976,-0.024161438,-0.022949971,-0.009099845,0.03955378,0.050450873,-0.03128917,0.016009713,-0.022366688,-0.020276025,0.0018179003,-0.016291134,-0.011194801,0.09295285,-0.056536008,-0.06723468,-0.028121354,0.0044231843,0.036748312,-0.023768736,-0.09098199,0.049162373,0.03781147,-0.00037566395,0.02464026,-0.039898343,0.014489274,0.0068918956,0.008900127,0.043296967,-0.047861185,0.023948288,-0.011416324,-0.039207716,-0.053817652,-0.009904997,-0.0058746724,0.015029485,-0.033134818,0.0049016722,0.033241693,0.05948939,0.046209484,0.031453807,-0.043851353,-0.015523885,-0.034585193,-0.090199426,-0.02579027,-0.07106593,-0.047303498,-0.011672933,-0.06989338,0.061011817,-0.06368404,-0.0724141,-0.010349542,-0.02920586,0.05407948,0.01106009,0.0043231756,0.106690235,0.0667223,-0.010772883,-0.014074472,-0.0040278276,-0.09918947,0.030123329,-0.010366888,0.06132829,0.015166415,-0.0033497917,-0.051623277,0.030047314,0.031145096,0.020449055,-0.023032548,-0.006335173,0.0049092663,0.046632703,-0.04607304,-0.11821231,-0.062842965,0.018969607,0.009452144,0.053361002,0.032623984,-0.008800188,-0.031701032,0.007940839,-0.068460755,-0.033911962,0.05398404,0.06158574,0.030351663,-0.033520877,-0.077564284,0.0056251767,-0.033978373,-0.043944743,0.04466242,0.01492271,-0.0033461694,0.058992025,-0.045919,3.9412133e-33,0.07358724,0.024828522,0.079100884,0.05873964,-0.004533563,0.020811547,-0.029649673,0.0379327,0.0006239579,-0.00042741917,-0.01231931,-0.0027797704,0.018005405,-0.027494676,-0.077838644,-0.020529369,-0.0026240118,-0.016671548,0.112092406,-0.01251091,-0.014036805,0.031267878,-0.029037403,-0.014598581,-0.0051229405,0.087573454,-0.02083801,-0.017031213,0.039147668,0.019826645,-0.0965548,-0.059703544,-0.11055741,-0.06723587,-0.01162329,-0.04433206,-0.04763974,0.00045021003,-0.07677323,0.05796306,-0.026655646,-0.04637131,-0.004833711,-0.12544426,0.10933647,-0.054053605,-0.09990178,0.07182136,-0.023300024,0.015827432,0.05240803,-0.042040765,0.08086371,0.007860002,-0.0784707,0.0020164084,-0.030989375,-0.01708596,-0.021477593,0.09516581,0.13010676,0.07394967,-0.07646562,0.055240188,0.06446075,0.0061901673,-0.04278869,-0.10424268,-0.12648182,0.1151493,0.01711538,-0.0107054785,0.14370278,-0.0059692715,0.05553998,0.020481022,-0.023961738,0.11737501,0.06587786,0.018819956,-0.0026601683,-0.018317392,0.013582704,-0.025434993,0.01243953,-0.025364054,0.06278744,-0.042979535,0.030842854,0.017822053,0.06990368,-0.13533616,-0.027984137,0.020930236,0.013455685,-5.1649128e-33,0.06397217,-0.033701245,-0.0035315685,-0.09011974,0.014588705,0.08625642,0.05964749,0.015728125,0.022125462,0.087632425,0.12916517,-0.0803819,0.051800005,-0.016125241,0.02879948,-0.014704716,-0.039037134,0.041359603,-0.043854963,0.044572223,0.0073673823,-0.0016765861,0.059347197,0.06356916,0.089294866,0.034508377,0.025133682,0.0061440915,0.032038763,0.04914786,-0.074006036,0.075245306,-0.08620661,-0.06099183,-0.0046523195,-0.0046828357,-0.060425263,0.036947038,0.026532928,0.040476307,-0.060293972,0.059115056,0.016530504,0.09384392,0.05889766,0.075196914,-0.09333569,-0.009975291,0.01643695,-0.017006395,0.030621856,0.055449978,-0.084165856,0.00041845342,0.02544503,0.07035027,0.008598593,-0.014174102,0.014659657,-0.034932118,-0.051541496,-0.060834825,-0.014782533,0.087673776,-0.0145639945,0.036333293,-0.05171924,0.0076314476,-0.009219399,0.012347409,0.055395667,-0.049951572,0.059513215,0.04052156,0.013751357,0.041402064,0.013120576,-0.054145224,0.007000415,0.027114732,0.018611679,-0.017306825,-0.040164314,-0.058761355,-0.0734498,-0.14141981,-0.012344443,0.10360648,0.01722537,-0.03406988,-0.025239674,0.061405182,-0.104807906,0.044430636,0.008166209,-4.182177e-08,-0.02602761,-0.0010795179,0.10006698,-0.03871517,-0.026528642,-0.02496281,0.027018625,0.001217744,0.08352633,-0.036875527,0.0016072119,0.06219987,0.011072735,-0.044132173,0.026527429,0.037063275,-0.0036980528,-0.040408514,0.030191878,-1.0311703e-05,-0.046326887,-0.0017451759,-0.021176474,0.026303869,-0.0048196227,-0.11276257,0.003698987,-0.034575887,0.04461505,-0.018855086,0.026705543,0.027792044,-0.04043124,-0.031401735,-0.027347613,0.021443054,-0.012717632,-0.007304753,-0.029701523,0.012055532,-0.08416671,-0.11539582,-0.074792534,-0.015121106,0.044447407,-0.0069893147,0.034871154,0.028624801,-0.026873332,-0.026961286,-0.055370018,-0.013085913,-0.027859278,-0.0993131,-0.032189805,0.04229622,0.033124145,-0.06934879,-0.017333519,-0.16185533,-0.045136243,0.013720306,0.142684,0.025894063 +1.14.14.79,A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.,384,0.99999994,-0.0540175,-0.041310288,0.0016843082,-0.05583054,-0.005443556,-0.011018288,0.060103223,0.14034152,-0.01233875,0.06823476,0.012230684,-0.030521313,-0.045978222,0.028631885,-0.03277569,0.038109142,-0.08038438,-0.028738147,0.04721791,-0.03963903,0.073147014,0.025711173,-0.0044300864,0.0032225288,-0.021302449,0.03214972,0.08736826,0.035423398,-0.05627596,-0.047672756,-0.10264692,-0.014628983,-0.022886004,-0.015418931,0.0601327,0.070110045,-0.07718675,-0.038069367,-0.015598159,-0.045510273,0.07652432,-0.040764533,-0.08031699,0.029836698,0.023232974,0.009985136,-0.024226718,0.062032748,-0.0020466114,-0.028578287,-0.046872094,-0.06565241,-0.027637616,0.01920167,-0.0075993794,-0.0014069598,-0.032787435,0.03318046,-0.005848095,0.030064227,-0.0005645257,0.04512799,0.0007201529,-0.027073018,0.05564393,-0.035969313,0.02344367,-0.059542585,0.006911079,-0.08789508,-0.06043037,-0.081844114,0.011662782,0.026089894,-0.09804903,0.050213538,-0.013581075,-0.05596132,0.04038949,-0.041238762,0.08830157,0.04891583,0.039029486,0.08881219,0.058853976,7.3565825e-06,-0.01154402,0.046706658,-0.046903774,-0.027407764,-0.0054719364,0.034811836,-0.08946774,-0.04470937,-0.0841774,0.02501268,0.038145356,0.03273076,-0.018594617,0.019179171,0.07600551,0.044797357,0.058329824,-0.077794366,-0.0924869,0.03545125,0.032935705,0.009607537,0.06478796,-0.03711642,-0.038965397,0.048628584,-0.038593,-0.046899684,-0.0044735814,0.04575144,-0.03491065,-0.06545006,0.050888352,-0.046045523,-0.035643317,-0.00081721385,0.074627854,0.039045144,-0.01769883,0.035845693,-0.06327455,3.9379277e-33,0.07543843,0.07567624,0.007806568,-0.008469114,-0.018901944,-0.0015237486,-0.038176883,0.07163779,-0.11552861,-0.040058035,-0.05540803,-0.071955934,0.019518016,0.0011933757,-0.0362636,0.017319279,-0.048631094,0.06995296,0.058121398,-0.02643056,-0.050823197,0.02569734,-0.05786987,-0.016565368,0.0003874363,0.06012825,-0.061509356,-0.02076263,0.058447134,0.017090632,-0.012926497,-0.019260595,-0.020784494,-0.0595293,0.016300658,-0.038469106,0.0062384326,-0.010044161,-0.08867005,0.043522023,-0.026695965,-0.016336562,0.061101124,-0.09170294,0.051327035,-0.0010859106,-0.08993262,0.049481884,-0.042476952,-0.007126586,0.08285185,-0.07753959,0.035390485,-0.040322915,-0.07576111,0.050757263,-0.0027531509,-0.01740263,0.026267957,0.08087903,0.1307197,0.082074724,-0.029969659,0.037829295,0.0094784135,-0.016209096,-0.050734464,-0.011083572,-0.09062842,0.09710801,-0.051076815,-0.03664743,0.07539934,-0.041108187,0.040531203,-0.03037902,0.00058888586,0.09730282,0.028480807,-0.010382281,0.0675954,-0.039681252,0.046742775,-0.062368702,0.023260461,0.032022893,0.08389594,0.0040061283,-0.072002865,0.050693322,0.08218425,-0.09717931,-0.06197112,-0.010585771,-0.03823583,-5.088467e-33,0.042116962,-0.06502219,0.042964593,-0.109692425,-0.030388424,0.07789805,0.05256186,0.03150354,0.015015316,-0.015166761,0.14636454,-0.07690122,0.017165031,-0.040451992,-0.0028576637,-0.040850066,-0.08880818,0.025653945,0.028189043,0.097412765,-0.0097209215,0.0040736767,0.011901192,0.009690326,0.015617241,0.021784682,0.012275071,0.021893369,0.030065093,0.045810323,-0.0358378,0.043793775,-0.08750102,-0.08679721,-0.018491488,0.03197154,-0.07824841,-0.011179864,0.0041212193,0.0404593,-0.061111256,0.04393335,0.04597442,0.052472994,0.040558558,0.059989247,-0.07267091,-0.04860227,-0.027607147,0.0012262308,0.049412932,0.0092819715,-0.03453509,0.03399778,-0.10347887,0.041905724,-0.041551746,0.077291,-0.03079016,-0.004597919,-0.04884047,-0.08452879,-0.022268124,0.018440137,0.09472293,0.059762113,-0.07625879,0.059227295,0.048856534,0.0017015011,0.06602558,0.024035228,-0.026903488,0.049141116,0.014480617,-0.0074998243,-0.014309724,0.014332582,0.019074552,0.037279975,0.038337376,0.022166265,-0.02413016,0.023213947,-0.04771836,-0.07385841,0.010409308,0.11244675,-0.00389409,-0.032306828,-0.05239589,0.04063954,-0.11343142,0.035710376,0.033645038,-3.8848928e-08,-0.0019547525,-0.057922814,0.004424603,-0.023650736,0.0067179995,-0.060484,0.0507433,0.02350933,0.032960217,-0.017659333,-0.030036787,0.07518861,-0.039942913,0.031657062,0.027914245,0.011228247,-0.007848251,0.04155216,0.022530355,0.018264577,-0.035563666,-0.011648487,-0.014094155,0.004833309,-0.00065302086,-0.03267901,0.04316504,0.006613789,-0.023531139,0.038676392,0.050539922,0.037596337,-0.039985247,-0.0018851527,0.015219974,-0.0060851434,-0.07824933,-0.02032694,-0.06292927,-0.016226614,-0.011845548,-0.07522033,-0.05918003,0.011447347,0.048269033,-0.014997469,0.06205364,0.011230861,0.048865773,-0.015888428,-0.058308475,-0.017912678,-0.023138262,-0.1194289,-0.09777198,-0.042181212,0.0936282,-0.014493007,-0.07006192,-0.12090667,0.063006274,0.017563948,0.20768616,0.00227398 +1.14.14.80,"A cytochrome P-450 (heme thiolate) enzyme. The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1). The plant enzyme CYP86A1 also acts on laurate (12:0). The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position. The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4).",384,1.0,-0.057401404,-0.01149367,0.009913451,-0.067254454,0.04236141,0.09029923,-0.05120429,-0.0152630145,0.010403011,0.026609842,0.062160198,0.0101408325,-0.06556941,0.065874994,-0.021972729,0.06466137,-0.013398236,0.0021138974,0.027871465,0.0396,0.08450838,-0.008809873,-0.015624157,0.027183192,0.0424171,-0.025409942,0.015998496,-0.008379688,-0.04772768,-0.0649108,-0.019392835,0.0527193,0.016197545,-0.027627273,0.025732929,0.028618531,-0.0045668087,-0.09739497,0.022238154,-0.029998517,0.07707252,-0.03380589,-0.091338135,-0.0015164849,-0.03653447,0.002974228,0.036276992,0.019593826,0.023897199,-0.057854008,-0.048596222,-0.061045773,-0.036105044,-0.016660083,-0.067925446,0.04272835,-0.01862151,0.025248375,-0.00105348,0.028450752,-0.0027289088,-0.008831223,-0.027636942,0.0424299,0.016561087,-0.0629401,-0.017115451,0.013402459,-0.021935936,-0.07261555,-0.06279982,-0.08028069,-0.023261799,0.021911575,-0.012471765,0.058126904,0.027526777,-0.07032711,-0.04353024,-0.016909176,-0.0032534944,-0.0010636866,-0.0027731692,0.046162058,0.09744808,-0.034846514,0.0073252846,0.08350377,-0.0061965734,0.041647498,0.09287491,0.060730673,-0.064169265,0.022388227,0.006419706,0.097910434,0.04478213,-0.036328487,0.049744118,-0.03759063,0.059836358,0.0420808,0.001781435,-0.11590624,-0.0036459637,0.055564996,-0.026428444,-0.0024296795,-0.004285212,0.01574435,-0.0647751,-0.024476305,-0.02299776,0.005673667,-0.019351402,0.0126264645,0.023902178,-0.027965153,-0.06506208,-0.032579307,-0.037777416,-0.05161273,0.03394776,0.07207231,-0.009842565,0.057046242,-0.10530752,2.9468413e-33,0.09776687,0.033506345,-0.008958647,0.0049913456,0.008848728,-0.048098683,-0.03604302,0.002815407,-0.105973065,-0.024240732,-0.09233082,-0.058916032,0.013321558,-0.02351724,-0.04365604,-0.00046954709,0.011978497,0.03487051,0.07436759,0.009102828,-0.0044628945,0.043251246,-0.077730395,-0.056004234,-0.011393349,0.064957835,-0.06897761,-0.033226784,0.022988448,-0.014119606,-0.037930146,-0.108003,-0.10483156,0.05513698,0.07775671,-0.0026696972,-0.023723401,-0.09150259,-0.030457309,0.042480893,-0.06167889,-0.0077925087,0.08357912,-0.031797264,0.043987233,-0.021766182,-0.12053529,0.045924567,0.056493863,0.075806856,0.08574024,-0.041685984,0.08828016,0.06900408,-0.113584004,0.05447285,-0.030080928,0.011638278,-0.010264925,-0.0153567465,0.035232898,0.054416254,-0.05452818,0.030889753,0.054072436,0.03626083,-0.086250365,-0.0073598875,-0.050856765,0.11303325,-0.03322844,-0.06130984,0.0912858,0.044254135,0.07845141,-0.0033147936,0.01295938,0.035335265,-0.0015908236,0.08863144,0.051992618,-0.023666224,-0.0005015112,-0.04483788,-0.086066626,-0.040252205,0.033890624,-0.0026677886,0.013610382,-0.0013498635,0.09273499,-0.115405336,0.055331856,0.00092120934,-0.028985532,-4.684258e-33,0.10647706,-0.022633685,0.10347279,-0.09429548,-0.06654118,0.03291686,0.015779149,-0.07548843,-0.020058164,-0.025356721,0.054224145,-0.06739174,0.032586575,-0.026400818,-0.07203673,0.04184959,0.03656985,0.08894423,-0.06170277,-0.0061926544,-0.068893746,0.05103408,0.012772184,0.085717715,0.05692846,-0.05950599,0.1025759,0.052095603,0.04907173,-0.003654524,-0.025175134,0.04697699,-0.056543425,-0.035607077,0.008248233,0.03284028,-0.11101052,-0.0029032554,0.03666162,0.06563464,-0.029933987,0.02194168,7.354832e-05,0.064173006,0.04930312,0.066906966,-0.068826064,0.012505556,-0.020635039,0.0051279822,0.025995424,0.057547536,0.02879252,0.04211817,0.08888668,0.019065233,0.03848779,-0.005016811,-0.009858548,-0.050603822,0.023181682,-0.04485972,-0.024971616,0.032142844,0.013896981,0.05727813,-0.0786184,0.02291793,-0.06503115,0.031888682,0.019347982,0.0038321337,0.033707388,0.08128953,-0.026004149,0.019080885,-0.011192946,-0.07061792,-0.04195108,-0.035330735,0.015746688,0.018550582,-0.03312173,-0.07496564,-0.029022045,-0.07124345,0.01845434,0.099189825,0.026302215,-0.056070536,-0.0023219641,0.019144531,-0.0039974027,0.055806775,0.06341134,-5.1212854e-08,0.031726927,-0.04829913,0.047174986,-0.10217525,-0.06517344,0.028174032,0.042159148,-0.06962889,0.06076727,-0.088061646,-0.06688931,0.07825793,0.0007075447,-0.018332414,0.052656032,0.0023456905,-0.018748036,-0.002129981,-0.0104473075,0.023558138,-0.03583471,0.027619299,-0.1489174,0.05804972,0.031576395,-0.02396435,0.030419765,0.1126043,0.04647031,-0.015201589,0.025811458,0.05118205,-0.013935773,-0.029239982,-0.057303023,0.064572245,0.0020989517,-0.031095704,-0.030859016,0.055223495,0.011677989,-0.104067825,-0.05908892,-0.043194305,-0.028106822,-0.024156418,0.014666894,0.026912082,0.03828221,0.009446043,0.05027262,0.0415846,-0.054187004,-0.09809067,-0.052409027,0.015893847,0.04511521,-0.044618003,-0.023754416,-0.08560644,-0.029697064,-0.03815744,0.13324046,-0.02352346 +1.14.14.81,"A cytochrome P-450 (heme-thiolate) protein found in plants. The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin.",384,1.0,-0.049787484,-0.052268863,-0.074861586,-0.041462336,-0.003997496,0.027917355,-0.040662598,0.037841246,0.048405573,0.006045526,0.019992836,-0.032800276,-0.0551854,0.03665039,-0.054190878,0.038108308,-0.07007006,0.028290719,-0.057201315,-0.04937156,0.07586266,-0.043264806,0.053179026,0.020146323,0.0010410893,0.0010821754,0.03214578,0.034942143,-0.02245474,-0.14147545,-0.0021248746,0.024531616,-0.03321799,-0.043840628,0.028967448,0.07154001,-0.059399858,-0.054118387,0.06931248,-0.016380856,0.058620032,-0.02034977,-0.06903596,-0.038007285,-0.071369104,-0.021748547,-0.07719731,0.017892903,0.10679769,-0.042176068,-0.038901757,-0.059153058,-0.05316342,0.042623986,0.009487093,-0.064665996,-0.02075222,0.011081288,-0.019889478,0.036493078,-0.0043861037,0.034388572,-0.031077283,-0.018104294,0.00046281927,-0.0053258305,-0.02315637,-0.06830627,-0.008845353,-0.04026726,-0.0030758658,-0.060100514,-0.014403344,0.03882922,-0.04784689,0.08117442,-0.025152637,0.05707499,-0.03409749,-0.041348454,0.0024330593,0.07232357,0.020908592,0.11285518,0.090606436,0.0013737963,-0.0852093,0.027003761,0.001809454,0.02517852,0.050197918,0.059652984,-0.026929814,-0.0010338472,-0.025478682,0.012709381,-0.0048242793,-0.03753811,0.03587404,-0.0016430733,0.031010801,0.037075944,0.016490908,-0.070554025,-0.033950422,-0.019050408,-0.014633605,0.010409894,0.061242267,-0.009856166,-0.049778312,-0.046863228,0.054655902,-0.002790447,-0.037577864,0.06720856,-0.03920048,-0.051216546,-0.019380018,-0.029742958,-0.02501923,-0.05081919,0.05468428,0.042429663,-0.01741814,0.02332851,-0.11270311,5.2122143e-33,0.11441106,0.02196486,-0.025485165,0.04950829,0.012109821,0.036285926,-0.062068637,0.07717613,-0.061391227,-0.038294576,-0.14366212,0.00022920384,0.05027766,-0.048764464,-0.030798621,-0.04989136,0.0036531228,-0.0059548193,0.031093353,-0.002096535,0.0099378675,0.011819017,-0.07780257,-0.025979048,-0.05605807,0.09280119,-0.05652753,0.0008870785,0.007057038,0.0046054395,-0.022956893,-0.12912107,-0.04033417,0.027195983,-0.0027583335,-0.043824475,0.0063553844,-0.04005901,-0.028741335,0.07783584,0.02553653,-0.030335868,0.04756787,-0.02999369,0.03522268,-0.032863557,-0.107523814,0.037893753,0.04697756,0.08833607,0.0704781,-0.026219737,0.14311956,0.019120079,-0.1279405,0.010332008,-0.007942259,-0.00684543,0.050363325,0.090268515,0.05625595,0.09690546,-0.01947546,0.0017357726,0.020590158,0.03171056,-0.07810837,-0.035074152,0.033983182,0.1184849,-0.028213223,-0.057068326,0.0826686,0.0077486965,0.11207858,-0.038911365,-0.011210058,0.06671385,0.024224354,0.03323239,-0.018120991,0.028858181,-0.02096731,0.020479105,-0.087025546,-0.0044096047,0.06664127,-0.028974632,-0.057259437,0.028564412,0.061735883,-0.09403569,0.04177819,-0.019877743,0.036416523,-5.3996175e-33,0.12185498,-0.064557664,0.027557867,-0.11966512,-0.05604911,0.087751515,0.051438943,-0.03063274,-0.04100582,0.029020105,0.09332101,0.009655808,0.059321776,-0.006809284,-0.043726932,0.009749983,-0.016122049,0.021111317,0.023237318,0.007809258,-0.048125505,0.05264577,-0.023323234,0.084839135,0.023584943,0.03802504,0.06123387,-0.025679275,0.022723751,0.017265558,-0.03807131,0.02449032,-0.075736195,-0.007191449,-0.048575226,0.055226803,-0.047390822,-0.034150213,-0.048437655,0.008422187,-0.06712869,0.04849111,0.008187785,0.012605644,0.06592237,0.052250706,-0.06113677,-0.019369006,-0.044473153,0.019074114,0.07979788,0.047348045,-0.008130313,0.0724926,-0.004913222,0.026442606,0.030047493,0.009601969,-0.019928329,-0.001517067,-0.037029784,-0.054432664,0.022256881,0.050220437,-0.008427985,0.06261636,0.012083505,0.013293141,0.071896695,0.019875932,0.023569886,0.055327367,0.06345767,0.063428044,-0.021590035,0.04353484,0.04254985,-0.04288527,0.007929022,-0.032562576,-0.031881347,-0.024353428,-0.047993194,-0.058426216,-0.06690606,-0.0933903,0.012295756,0.09296044,0.03907516,-0.004520455,0.06641932,0.0032488033,-0.038523696,0.07789114,0.10505865,-4.9788724e-08,2.0744494e-05,-0.08659838,0.0028348637,0.004689266,0.07141072,-0.0051358673,0.018732194,-0.055019855,0.03145046,-0.06436455,0.018286549,0.037351064,-0.058165308,0.004785186,0.056686945,0.07596592,0.07418679,0.027268669,0.01825333,0.07220509,-0.06906366,0.05339681,-0.09543802,-0.006625015,0.037062574,-0.113371715,-0.031799305,-0.005077052,0.015733216,0.011474089,0.025381537,0.04813463,-0.037290834,-0.08470999,-0.042690556,0.02917532,-0.027686525,-0.010893185,-0.045224812,0.021366056,0.0041187294,-0.05231284,-0.08018514,-0.042225286,0.005268787,-0.028756402,-0.020081127,-0.004660365,0.012747466,0.0052070203,0.04094306,0.02917231,0.05039786,-0.1175888,-0.11406885,-0.02279472,-0.021040782,-0.084033266,-0.040212195,-0.045654666,0.013147624,0.0051624896,0.18802926,0.013991715 +1.14.14.82,"A cytochrome P-450 (heme-thiolate) protein found in plants. Acts on a number of flavonoids, including the flavanone naringenin and the flavone apigenin. Does not act on 4-coumarate or 4-coumaroyl-CoA.",384,0.99999994,-0.041117907,0.011186806,-0.060989622,-0.027742583,0.091527134,0.12455952,-0.02220019,0.07391354,0.038923196,-0.0058366545,0.036079817,-0.027884189,-0.0725613,0.008726965,-0.04516049,0.01789738,-0.034350973,0.027523115,-0.02947964,-0.084022895,-0.011861515,0.039053384,0.034996938,-0.00091785024,-0.028187536,-0.00070927496,-0.0108570345,0.028814148,0.004121958,-0.041875724,-0.034989957,0.06472824,0.0011271525,0.04177485,-0.032678112,0.057135966,-0.04286754,-0.1248854,0.021343978,-0.010010562,0.0950319,-0.015474879,-0.035122074,0.030506084,0.012797955,-0.02857704,-0.07142131,0.048047945,0.036598157,-0.022273257,-0.012570862,-0.000630634,-0.08256317,0.02422938,-0.019265477,-0.003666439,0.0049136686,-0.009281124,-0.006314078,0.03068688,0.03728739,-0.0016551707,0.028245559,0.026605641,0.0022826393,-0.017522432,-0.058355026,0.028747965,0.016194927,-0.076115124,0.024904791,-0.06868983,-0.071466185,0.055389892,-0.09815065,0.103810646,-0.0657546,0.018984115,-0.01890439,-0.02990837,0.025621979,0.011289698,0.042442176,0.0857432,0.06723169,-0.035471853,-0.096791364,0.040491853,-0.011964418,0.0096386885,-0.00014579736,0.05591909,-0.006952698,0.017774446,-0.10270721,0.07238812,0.091406606,-0.0438914,-0.053105768,-0.003478318,0.016275533,0.029481404,0.040137764,-0.03239666,-0.07314317,-0.000469858,-0.038264956,0.0030346592,0.040952012,-0.047233406,-0.064951226,-0.057197582,-0.020396303,-0.09894965,0.033483,0.08916698,-0.017444668,-0.027136909,-0.03424674,-0.033010036,-0.054121315,0.004019396,0.04817013,0.011986599,0.00013300925,0.009906712,-0.09225143,3.1367387e-33,0.12770356,0.0111787645,0.0018080112,0.04969822,0.010010859,-0.02659474,-0.014399672,0.053156607,-0.021044439,-0.04402298,-0.08129892,-0.019304134,0.025209146,-0.01371963,0.011077362,0.008657156,-0.058908854,-0.03623414,0.056796655,-0.0048374813,-0.052339006,-0.00036996178,-0.05355856,0.038315363,-0.024333823,0.0676383,-0.049383283,-0.03665088,-0.0021075397,0.021778423,-0.06414419,-0.04675309,-0.018117962,-0.024722392,0.008738622,-0.0037149056,-0.08668988,-0.04446924,-0.11453469,0.07147321,0.004085924,-0.054988835,0.021380752,-0.0474813,0.03621047,-0.045440488,-0.13745067,-0.0017696519,-0.04746349,0.08720082,0.06817755,-0.0031925098,0.10737632,0.12069575,-0.05425407,0.026196087,0.002825863,0.05156901,0.018822854,0.04344032,0.11967216,0.034633376,-0.03468447,0.05491765,0.021648988,0.095109865,-0.042899642,-0.056949187,0.0042984313,0.14907543,0.0152288,-0.048650973,0.07100476,0.010416714,0.12713173,-0.0063751834,0.011107031,0.046812363,0.0036881878,0.054568563,0.022302028,-0.045156598,0.00772178,0.033476207,-0.048542622,-0.015082979,0.04102415,-0.024792956,0.0028514736,-0.010431749,0.09256828,-0.06028927,0.046633612,0.003637868,-0.033340294,-2.6062717e-33,0.061746914,-0.03397064,0.03176827,-0.037771616,-0.06395578,0.051238246,0.010211263,-0.10258172,-0.035408217,0.016060473,0.13408306,-0.043101065,-0.035048626,-0.010388678,0.006116146,0.025703752,-0.007025129,0.029476639,-0.014522566,0.0758427,-0.053835604,-0.022744866,0.06629754,0.030747645,0.047187045,0.03720589,0.0646898,-0.10876041,-0.019646602,-0.012455134,-0.034448363,0.021905132,-0.06949165,-0.050077543,-0.046133332,0.006132654,0.028019916,0.00092796807,-0.022770843,0.034912813,-0.029209021,0.06524112,0.035362653,0.075797096,0.040388316,0.050959766,-0.07925916,-0.0047710245,-0.033824805,0.0029717172,0.05030013,0.05546006,-0.014567272,0.052589517,0.0023023363,-0.0041834046,0.011473604,0.02714434,-0.018336797,-0.0062049814,-0.043642443,-0.06236828,-0.035303514,0.053196616,0.06721134,0.07562147,-0.012518985,0.09923697,0.010541833,0.025745997,0.02754147,-0.02777637,0.10147978,0.09153465,0.0021700317,0.0027788738,0.02154458,-0.002671192,-0.015053086,0.019699262,-0.048317853,-0.010938074,-0.021658057,-0.07316425,-0.063248664,-0.12715529,-0.08276384,0.06716249,0.071268916,0.017168257,-0.04545317,0.086779326,-0.037480697,0.01660636,0.06027235,-3.633838e-08,0.0022917085,-0.054491885,0.004669936,0.006683793,0.087792136,0.012669994,-0.018422231,-0.031474326,0.053720377,0.015893634,-0.005769521,0.06222517,-0.042848635,-0.011899808,0.011410667,-0.01871222,0.044429023,0.021749971,0.010335127,0.01786887,-0.08155061,0.054602917,-0.05176968,-0.013377291,0.017468851,-0.10494871,-0.016938325,0.0012582587,0.09078932,0.022549933,0.045289747,0.066418946,0.0019717126,-0.01098241,-0.051874112,-0.01687357,0.029423252,-0.048674636,-0.06861846,0.006429427,-0.07617695,-0.0050159465,-0.041461788,-0.041247047,0.021304475,0.0027896394,0.061520595,0.034951657,-0.006820206,-0.027973533,-0.06355453,0.031822618,0.013065223,-0.08381527,-0.09667704,-0.047439206,0.07864034,-0.06198935,-0.026314257,-0.15217344,-0.057799645,-0.020165458,0.16650301,0.03864532 +1.14.14.83,"A cytochrome P-450 (heme thiolate) protein found in plants. Also hydroxylates nerol and citronellol, cf. EC 1.14.14.84, linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}. The cloned enzyme also catalysed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.14.82, flavonoid 3'-monooxygenase) [3].",384,0.99999994,-0.090118356,0.022275956,-0.08082374,-0.0054066665,0.06719669,0.048172463,-0.053302202,0.06751158,0.03266554,-0.05936079,-0.0034280173,-0.016097227,-0.020040005,0.012512168,-0.09477787,0.03694534,-0.06251364,0.06166184,-0.024630565,-0.06895643,0.0129487375,0.0226879,0.022465004,0.069058634,0.062042754,-0.067726076,0.009534416,-0.036332335,-0.059354722,-0.026982553,0.029109698,0.009926937,0.050596118,-0.017792506,-0.067395546,0.098710544,-0.072843,-0.09216332,0.015777139,-0.002321982,0.03871113,-0.023287222,-0.049413234,-0.0033478898,-0.03539678,0.00948138,-0.054971915,0.011782427,0.034811053,-0.012840408,-0.05380632,-0.023177182,-0.019620806,0.0028178291,0.03899602,-0.043132897,-0.010899748,-0.032279447,-0.034801554,0.10431548,0.0075004753,0.002866667,-0.024517732,0.02912338,-0.0684831,0.036432356,-0.026838165,-0.0017006696,0.018715773,-0.055826757,0.0124387415,-0.06023455,0.05064137,0.01928353,-0.15634507,0.081335,0.024200961,0.029585795,0.022116372,-0.03246742,0.023546923,0.05612953,-0.003936029,0.081109114,0.05578105,0.026895635,-0.078119494,0.050506834,0.0032320868,0.08538173,0.046260603,0.061776754,0.010287204,-0.012340107,-0.020468343,0.076397896,0.05816746,-0.027302371,-0.048167646,-0.025695177,0.023947854,0.0108221965,0.05556146,-0.039854176,-0.08933833,0.0029193743,0.007726306,0.014330524,0.007183274,0.024567392,-0.010319252,-0.05281874,0.0056485618,-0.028961334,-0.029136501,0.09911246,0.010696588,-0.027852615,-0.038979657,-0.036211733,-0.05557002,-0.009552237,0.051270016,-0.014316855,-0.04005587,0.026290473,-0.025545051,6.097633e-33,0.04391434,0.027813075,-0.062842995,0.046280332,-0.016374826,0.00029946235,-0.08295526,0.069556236,-0.009170548,-0.05837838,-0.060134694,-0.0009929881,-0.015942207,-0.015838418,-0.047711138,-0.03466638,-0.010326069,0.0039673885,0.06858693,-0.021071116,-0.048172515,-0.04474622,-0.09228242,-0.021113336,-0.061493058,0.035768755,-0.038445175,-0.07017275,0.02193758,-0.01952154,-0.0025117593,-0.09292291,0.023572385,0.036865488,-0.04481634,0.0075544524,-0.06746572,-0.061290484,-0.09984397,0.12498312,-0.021746691,0.022717439,0.042050716,-0.04141957,0.07128249,-0.05147124,-0.11630605,0.07908379,0.052097984,0.07148896,0.0451224,0.014594905,0.053529356,0.016576087,-0.062225934,0.029460644,0.030376751,0.029491981,0.07872218,0.045797158,0.02090824,0.058685407,-0.0065650796,-0.037152063,0.09193733,0.0516579,-0.04914159,-0.029335722,-0.008290682,0.09285912,-0.00803037,-0.047376897,0.0310661,0.052258406,0.08521207,0.015815273,-0.04351696,0.018677726,0.04221475,0.0369455,-0.002041037,0.039016765,0.023641339,0.056106597,0.020414967,0.02270425,0.016137537,0.016148312,-0.0045168097,0.061214782,0.08738604,-0.10397192,-0.0035057624,0.04060329,-0.037177116,-4.6073354e-33,0.11105171,-0.09352379,0.026705356,-0.078925684,-0.011767568,0.078353144,0.018476702,-0.07145725,-0.03688803,0.016206015,0.12607393,-0.02664637,0.051293552,-0.028435377,0.017859604,-0.010995163,0.060470622,0.02608218,-0.04159866,0.011776275,0.010418148,0.04047376,-0.027419953,0.01806363,0.0268956,-0.024444915,0.03872763,-0.044155516,0.040036708,0.07476954,-0.057345603,-0.009014131,-0.048486777,2.2455912e-05,0.060493525,0.06050493,-0.011252187,0.0048859185,0.0010413527,-0.032438904,-0.050924316,0.059381414,0.022045258,0.035810128,0.03472605,0.10196005,-0.11235648,-0.030274918,0.014191462,0.019058138,-0.011532562,0.06595346,-0.0563952,0.03532524,-0.0052550994,-0.028883422,-0.007189098,-0.021003205,0.0048270943,-0.0995268,-0.03898706,-0.053605687,0.0074575744,0.004803428,-0.018378556,0.106385395,-0.025916312,0.112178795,-0.010082003,-0.04770705,0.0342138,-0.016650623,0.05170481,0.051954318,-0.04136967,-0.035320524,0.06813137,0.0006173276,0.018304328,-0.050856177,0.08493331,0.019655392,-0.019642202,-0.07322382,-0.032197773,-0.07509507,0.014375057,0.07152453,0.05612465,0.0023515546,0.014382214,0.08064531,-0.14611967,0.009599586,0.12280972,-4.829323e-08,-0.06542938,-0.09207878,0.04847724,-0.005223408,0.06342288,0.0125888735,-0.004520492,0.008969358,0.003542848,-0.0481564,-0.00056990434,0.10781065,-0.057943363,-0.009031883,0.017350173,-0.043092802,0.026385488,0.047272816,0.0249096,0.03544865,-0.03346283,0.055621266,-0.06942171,-0.074840225,-0.01682241,-0.10454797,-0.028244779,-0.018810408,0.09354454,-0.032265946,0.02109938,0.05073896,-0.018697519,-0.0185375,0.0033496239,0.014787961,-0.029612344,-0.021225642,-0.04332031,-0.037427247,-0.037536733,-0.059657738,-0.0071455254,-0.0028019228,0.026850594,-0.02755691,0.0066041085,0.0015686743,-0.003186696,0.0011113468,0.07849281,-0.013720442,0.091825634,-0.08507066,-0.06888678,-0.04208192,0.050765928,-0.085037634,-0.06254285,-0.063418366,-0.00545531,-0.022189146,0.22156356,0.057353728 +1.14.14.84,A cytochrome P-450 (heme-thiolate) protein found in plants. The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain.,384,1.0,-0.08063822,0.037932005,-0.03518006,0.010113956,0.0904053,0.07921616,-0.0224394,0.08200158,-0.0027142935,-0.038387936,0.038270794,-0.07205817,-0.031572744,0.014755633,-0.03596059,-0.0009751947,-0.080045186,0.012926522,0.017143918,-0.022442315,-0.041337483,0.058453962,0.026350034,-0.046448506,-0.0026251678,0.026428046,-0.003280416,0.07622532,-0.027792228,-0.06077091,-0.056138646,0.046114244,0.02814201,0.013109988,-0.008371785,0.099290825,-0.030527385,-0.07790404,0.06555009,-0.08047874,0.03682573,-0.011892358,-0.011771925,-0.020431308,-0.068193,-0.007593355,0.05532123,-0.011729587,0.0633891,-0.043248348,0.0125166755,-0.026595177,0.0009870542,0.054475788,0.03214343,-0.013742105,0.0794407,0.0011691487,-0.019888818,-0.032117985,-0.0017176092,0.00939587,-0.017513942,0.048206944,0.0066412883,-0.05050482,-0.03468751,-0.020234639,-0.035512954,-0.0825043,0.011714484,-0.05005233,0.04137139,0.016745182,-0.046147253,0.10151739,-0.009270153,0.0038582704,0.027150152,-0.009314351,-0.007902829,-0.03956101,-0.006220239,0.11558921,0.020589514,-0.030316312,-0.07210844,0.057268012,-0.11432931,-0.004985798,0.025637396,0.05817278,0.0081955,0.007813814,-0.084907,0.05380433,0.035602596,-0.017256532,0.037125397,-0.014914366,-0.010906929,0.07948858,0.01543718,-0.09001311,-0.004900378,-0.031305943,-0.063239336,0.041034922,0.08923807,-0.06904282,-0.003913576,-0.016694479,0.043993805,-0.015618305,0.027548615,0.09006226,0.018271469,-0.024262443,-0.026052874,-0.011461905,-0.014115462,-0.027832268,0.017180953,0.0015013015,-0.04704557,-0.018417953,-0.15865494,7.479966e-34,0.09043767,0.025338033,-0.013863751,0.025958426,-0.004955833,-0.014909851,-0.059896667,-0.007960089,-0.016557956,-0.039674893,-0.13452403,-0.08784214,0.085046634,-0.079315506,-0.05638621,-0.057125565,-0.08106556,-0.013257518,0.08551599,0.025638333,0.0010648658,0.023704942,-0.0036985674,0.0022612305,0.06824632,0.08702977,0.005591803,-0.034653623,0.029870395,0.004666201,0.01834253,-0.06272339,-0.06595868,-0.02496667,0.028446412,-0.071098424,0.035604488,-0.0112039745,-0.078427926,0.017170856,0.0035244026,0.00489945,0.043527145,-0.09982053,0.10567198,-0.06763576,-0.10283822,0.021512778,0.003588004,0.10153358,0.033759255,-0.089494735,0.081355035,0.024345702,-0.045009963,-0.0037164756,0.02235227,0.07715675,0.021668214,0.07904468,0.08290523,0.08836934,-0.018816499,0.042176932,0.025902959,0.06920147,-0.017551227,-0.032649316,-0.039419327,0.16793114,-0.02807716,-0.019984838,0.065099806,-0.057074096,0.099893115,-0.033131097,-0.059029702,0.01158305,0.11672831,0.031723563,0.04457605,-0.03250012,-0.031270828,-0.03719686,-0.05386494,-0.024128536,-0.008211493,-0.007283513,-0.023175186,0.07820958,0.09284413,-0.049899064,-0.038503602,-0.04297002,-0.040372077,-1.13003275e-33,0.04910107,-0.054272946,0.04772414,-0.06121928,-0.0429529,0.053646553,-0.01747649,-0.050296668,-0.00016565862,0.036179025,0.14528461,-0.018634306,0.05090247,-0.031029694,-0.0028775532,0.008302411,-0.07710617,0.0066548856,0.05563053,0.047787044,0.020870278,-0.028333506,0.02250393,-0.006225381,0.06597454,0.014965834,-0.02690816,0.005054517,0.08908866,-0.029146215,-0.03413133,-0.0072299032,-0.09161256,-0.049701773,-0.02405187,0.020033108,-0.018124428,-0.0071908343,0.054035056,0.036222138,-0.036005452,0.056466337,0.049092725,0.09336324,0.031823084,0.058745522,-0.065495774,-0.021591403,0.0150934765,-0.0021809954,-0.016880725,-0.0046425457,-0.05963986,0.015148479,-0.042639386,-0.0048648207,0.020545889,0.07431292,-0.0113858245,-0.0017119861,-0.0005915406,-0.08682217,0.0128518315,0.1185367,-0.015412718,0.07982155,-0.03282526,0.08689671,-0.0031884064,0.032958318,0.04934051,-0.014011794,0.0678687,0.047915295,-0.013637375,0.011523779,0.0338337,-0.00014154075,0.038987175,0.016618237,0.0062711616,0.03761693,-0.0436525,-0.011745925,0.020382985,-0.10858964,-0.038233202,0.08126712,0.037453495,-0.06708252,-0.060329277,0.084236234,-0.007373566,-0.009520428,0.071398504,-3.048648e-08,-0.07026324,-0.102541625,0.014943591,-0.030750927,0.08095431,-0.014302786,-0.02684822,-0.010005883,0.045415945,-0.01630956,-0.004388381,0.10304114,-0.03399359,-0.03592611,0.013620335,-0.013971055,0.0339302,-0.022187682,0.027699767,0.03697389,-0.037930757,0.006691488,-0.09855488,0.033796508,0.013024025,-0.07201142,-0.032173555,-0.0568319,0.04432026,-0.04774223,-0.0076624397,0.054077737,-0.06294598,-0.04221175,-0.019520467,0.0015888949,-0.079222456,-0.05023474,-0.034453567,-0.007017766,0.004022817,-0.0418354,-0.06817335,-0.036401395,0.005653194,0.0279004,0.04933318,0.02551876,-0.0108273905,-0.05102465,0.03124208,-0.038944043,0.04951098,-0.10503348,-0.115145445,0.073640965,0.049995672,-0.003929187,0.05425123,-0.053230263,-0.02411297,0.016843392,0.12689896,-0.00070981315 +1.14.14.85,"The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme-thiolate) enzyme. It catalyses a reaction in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.",384,1.0,-0.014028743,0.005829787,-0.09965758,-0.021265646,-0.060536206,0.080965556,-0.05691669,0.032677382,0.048977014,0.0060515506,0.010277217,-0.022810739,-0.05587728,-0.027011415,-0.0535694,0.07794745,-0.057064474,0.038063224,0.0011683727,-0.07693001,0.021776024,0.06685373,0.026289294,0.008848703,0.057773598,0.033869743,-0.0014853147,-0.016618032,-0.035317525,-0.042250108,-0.019836165,0.0007324792,0.041662198,0.014278023,-0.024784608,0.07647213,-0.07538418,-0.03840365,0.055321295,0.018001303,0.036276422,-0.039086685,-0.04071564,-0.00038333825,-0.03978623,-0.015989015,-0.009311935,0.0056527965,0.004164941,-0.05014762,0.006144474,-0.02980322,-0.05127961,-0.013142044,-0.027425187,-0.08644585,0.06467374,0.022449644,-0.06828775,0.019300641,0.04123923,0.03603919,-0.024762588,0.060066324,-0.016308358,-0.06945868,-0.037145182,-0.028765516,0.019104157,-0.09650123,-0.012223678,-0.11431904,-0.0763425,-0.048071545,-0.07335249,0.046065435,0.0032090745,0.022931717,-0.021910893,-0.04693747,0.09199477,0.062270608,0.021304645,0.15441935,0.03863187,0.049334828,0.02907962,0.04171716,0.04246929,-0.03389458,0.046055112,0.010488778,-0.04726636,-0.01698879,-0.10343395,0.0539088,0.013301492,0.01040672,-0.034201425,-0.009734024,0.05257622,0.060237706,-0.08121003,-0.07396894,-0.11116793,-0.0115914745,-0.029627543,0.011090705,0.031517327,-0.047178265,0.0071896263,-0.042690843,-0.019273482,0.034215637,0.012924131,0.06891162,0.008223952,-0.036878996,-0.010862747,0.020134874,-0.06056395,-0.0050111515,0.04212323,0.06717598,-0.030582678,0.0044949986,-0.079468936,2.1266957e-33,0.08960688,0.061240483,-0.019628057,-0.06959288,0.012013728,-0.029912956,-0.050313067,0.05890968,-0.08178054,-0.02030704,-0.112978704,-0.03289104,0.012452619,-0.049125466,-0.007104456,-0.023406109,-0.044807646,0.029272353,0.06697966,-0.025517255,-0.03986648,0.008260348,-0.07648533,0.030080771,-0.026711162,0.049687773,0.024833951,-0.011903795,0.023366243,-0.010478818,-0.006098904,-0.11604362,-0.04318816,-0.020495085,-0.0572485,-0.04334974,-0.056922775,0.024119994,-0.04791814,0.054327954,-0.024994032,0.04579478,0.04563882,-0.0083661275,0.07880574,0.018337933,-0.079200305,0.10544427,0.03929484,0.0514882,0.010331942,-0.015753703,0.16883756,0.07802987,-0.08454328,0.04960544,0.037262954,0.021019913,-0.00028189836,0.069741,0.009271489,-0.0018253013,-0.050500594,0.04917139,0.0005093384,0.04085873,-0.01810976,-0.06543793,0.034757327,0.14576776,-0.057479218,-0.0049769524,0.039011817,0.013546506,0.04440305,-0.021861989,0.04140369,0.02318686,0.02679481,0.04207056,-0.025857458,-0.01295306,0.018556282,-0.019168299,-0.0073290025,-0.05262574,-0.024479588,-0.00973947,-0.0608157,0.0823185,0.057648726,-0.0030225955,-0.055225212,0.00079750014,0.041306313,-2.4548389e-33,0.067727745,-0.09024832,-0.011982918,-0.11067413,-0.040339205,0.060386356,-0.046610307,0.017549543,0.019594433,0.058381233,0.060106825,-0.018868625,0.10423227,0.049807776,-0.016383342,-0.09775313,0.004453357,0.11024223,-0.001253123,0.04880775,-0.045704655,0.08392461,-0.01935628,-0.007274752,0.038386077,-0.0031134905,-0.0057366197,0.034330238,0.0027853067,0.022132227,0.0380429,-0.016906083,-0.11526006,0.011595474,-0.012583474,0.10579791,-0.0003369995,0.004354437,0.019090263,0.104308605,-0.0563169,0.07360599,0.031297106,0.059249096,0.104881115,0.0030680953,-0.12893575,0.0779806,-0.03927553,-0.05638786,0.019611545,0.04171176,0.041988287,0.033129964,0.029531084,0.0011065434,-0.0064760665,-0.0331052,-0.03597267,-0.043288585,-0.030918999,-0.09412603,0.00018445695,0.023171622,-0.048192076,0.047018256,-0.0054290676,0.024573408,0.035219714,-0.0083858995,0.06483358,0.018968465,-0.0025253184,0.086620085,-0.0107981,-0.042765014,0.018285764,-0.030119576,0.024624458,-0.041028973,0.008194642,0.040719423,0.020506456,-0.09828446,-0.010830823,-0.07472486,0.00792737,0.12612487,0.029285192,0.0034517865,0.012439474,0.048446957,-0.06613476,0.05523996,0.05933251,-3.3444728e-08,0.02077064,-0.085045055,0.042905215,0.002169801,0.028335318,0.012728163,0.032505985,-0.03851369,0.022648642,-0.09639545,-0.003462047,0.068786934,-0.0411616,0.037613295,0.066527165,-0.02544465,0.06979655,0.010397676,3.6676964e-05,0.022399716,-0.0063805636,0.007942883,-0.061826862,-0.020726595,-0.007609575,-0.08375664,-0.019411566,-0.025504697,-0.015229387,-0.004468782,0.067935325,0.03491657,-0.004525567,-0.0186805,-0.03802063,0.044761147,0.00030361893,-0.029425438,0.011457945,-0.027398944,-0.03788757,-0.09895223,-0.029467048,-0.013046851,-0.018047288,0.007289573,0.054149535,-0.012830017,0.016354628,-0.02276145,-0.024173703,-0.002748275,0.033208884,-0.113282084,-0.11706172,-0.015810898,0.019529482,-0.045349807,-0.050753694,-0.11236302,0.04648084,0.022121286,0.2083105,0.0025828655 +1.14.14.86,A cytochrome P-450 (heme thiolate) protein found in plants. Catalyses three successive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid.,384,1.0,-0.0843282,0.026888892,-0.006710099,-0.035739366,0.090461336,0.11237719,-0.037917662,0.058938235,0.038825188,0.055049565,0.042890865,-0.03746848,-0.048470076,-0.03043015,-0.04646299,0.056600515,-0.101523206,0.038042873,0.014494622,-0.07530863,0.0135844555,0.020917706,-0.008770219,-0.0034727438,0.054079454,0.010416166,-0.023955552,-0.039442692,-0.04868664,-0.057830792,-0.09193823,0.013452885,0.027352633,-0.010949605,-0.013450017,0.0913022,-0.09553805,-0.047072392,0.049621437,-0.04849208,0.04946468,-0.003549541,-0.11439449,0.0039661755,-0.055729903,0.022716016,-0.03127094,0.04061252,-0.0039062886,-0.026068775,0.023172123,-0.025324173,-0.024449272,-0.016132032,-0.033356935,-0.037756547,-0.029568674,0.08268013,-0.009622827,0.046400875,0.08866149,0.030711643,-0.04030405,0.005182246,0.020213164,-0.07870836,-0.036259048,0.05339553,0.021142147,-0.058384553,0.0141249485,-0.071579315,-0.033740293,0.02522368,-0.055322822,0.085545436,-0.04244181,-0.017662838,-0.031482764,-0.021869862,0.07397083,0.025149193,-0.0093921395,0.054147642,0.061359856,0.0020872345,-0.064467944,0.060409933,-0.042332098,0.012429471,0.041592907,0.02408724,-0.02292544,-0.0128447,0.007188041,0.05535356,0.027944008,0.001449007,-0.01651965,-0.05064608,0.038019277,0.098767295,-0.03256256,-0.088465564,-0.016574346,-0.027335789,-0.04004688,0.0022082212,0.030953838,-0.06656545,-0.044586092,-0.06172258,0.014266086,-0.056254108,0.021467753,0.059538785,0.022740645,-0.05397093,-0.06780063,-0.025972035,-0.03086371,-0.014035359,0.004724276,0.015532354,-0.06810476,0.014787906,-0.043035515,2.3784433e-33,0.09420665,0.04693735,0.005957108,0.013810195,0.0015335777,-0.023489796,-0.056506235,0.053496707,-0.04659811,-0.022793913,-0.10062626,-0.10429725,0.06419029,-0.067616284,-0.03319521,0.034238562,-0.049075007,0.012584646,0.12004307,0.0021852746,-0.047769587,-0.015810618,-0.071084484,0.0026282712,-0.031135468,0.047438446,0.004666114,-0.07857163,0.0007092429,-0.026871387,0.015348189,-0.055271436,-0.0624648,-0.030707475,-0.027860742,-0.044213217,0.017233621,-0.005822994,-0.077138394,0.072698295,-0.030126857,0.001548281,0.08309595,-0.056998003,-0.016724149,-0.0055973413,-0.10854737,0.012076619,-0.005048712,0.061627865,0.06614548,-0.024723506,0.107731834,0.05269065,-0.04472453,0.037296794,0.022023635,-0.020626996,-0.0046304683,0.04553905,0.10412955,0.038031884,-0.031490967,0.020100715,0.026517563,0.0057754763,-0.09263927,-0.015709024,-0.021788694,0.15428784,-0.077234514,-0.06190275,0.06389156,-0.09271,0.0520461,0.027962543,-0.067398496,0.082277074,-0.055422336,0.10044845,0.04346579,-0.0104281,-0.009796089,0.0042150933,0.007812677,-0.025690455,0.04392949,0.022588944,0.05522743,0.061082687,0.038130533,-0.08485306,-0.0024087366,0.01425911,-0.048280235,-2.4905926e-33,0.14545676,-0.04626605,0.043988135,-0.043873277,-0.017601576,0.056362655,-0.028676832,-0.044798248,-0.019473394,0.0186174,0.14808705,-0.041245345,0.01715724,0.047767196,0.061526578,0.014303311,-0.02419913,0.042265527,0.012732171,0.036607515,-0.01724842,0.016811857,-0.0070038033,0.06078817,0.04084132,0.03877573,0.0013482429,-0.042358674,0.035764553,0.02097122,-0.0133929085,-0.046502586,-0.046557337,0.012657833,-0.01571277,0.043157216,0.02445811,0.019024694,0.012937142,0.10793098,-0.02216272,0.10587179,0.024555536,0.049627226,0.05224748,0.022919541,-0.05587791,-0.06434391,-0.0113210725,-0.036414873,0.12878694,0.026831998,-0.050606485,0.0076290853,0.014867172,0.05363005,-0.059012167,0.10490505,-0.06380669,-0.01030887,0.0025631585,-0.07958845,0.006519446,-0.027978852,-0.037325736,0.057402633,-0.03833086,0.084913455,-0.024003902,-0.030782763,-0.031072823,0.020181807,0.069844306,0.08685576,0.034753256,-0.030405635,0.019871037,0.026316883,0.025577769,0.022690466,-0.025450995,-0.013579868,-0.044358037,-0.054825544,-0.015615537,-0.06850585,-0.060017005,0.10677576,0.06857983,-0.06250241,-0.052296333,0.05108022,-0.0021275498,0.1054232,0.08458238,-3.0436343e-08,0.028518846,-0.09695908,0.014739525,0.0046081743,-0.01725638,-0.020409476,0.015706358,0.016948773,0.03696894,-0.06923627,-0.0051439726,0.05244368,-0.034824632,-0.0069327815,0.056778684,-0.018553585,-0.020312198,0.023562578,0.032431122,0.020480465,-0.059530217,0.05171827,-0.07215937,0.0061124964,0.06021756,-0.043877877,-0.012485617,-0.055245478,0.033945844,0.030291623,0.068422265,0.036592867,-0.036638886,0.0055331727,0.06913309,-0.01080182,-0.022586977,-0.05191997,-0.032879394,0.010420121,-0.06407759,-0.054702748,-0.1064003,-0.019288719,-0.023924686,-0.018541958,0.04935675,0.05590275,-0.02842733,-0.022608737,-0.053817227,0.03684073,0.027190678,-0.06652967,-0.044182733,-0.0042379433,0.08664487,-0.08571169,-0.02781944,-0.10362853,-0.01297715,-0.002499994,0.17546535,-0.0121160485 +1.14.14.87,"A cytochrome P-450 (heme thiolate) protein found in plants. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively.",384,0.99999994,-0.084887736,0.023334865,-0.043430865,-0.019696822,0.08802828,0.08575268,-0.032891057,0.082590975,0.0076028993,0.003347145,0.057082333,-0.06960819,-0.04563319,-0.03728841,-0.053897493,0.033141322,-0.084181316,0.031482417,-0.050091743,-0.07376849,0.030703107,0.0506611,0.030359775,0.009686318,0.022724299,-0.012234961,0.035002906,0.044417087,-0.029298462,-0.06924996,-0.024325317,0.032879338,0.019441035,-0.0201138,-0.014093218,0.098772794,0.0030167345,-0.08230829,0.017955296,-0.02389016,0.05692667,-0.043166053,-0.06955993,0.016099256,-0.005180089,-0.0059532993,-0.0036946512,0.05460013,0.029878529,-0.030581638,-0.038942985,-0.06549783,-0.045124464,0.048687637,0.00079330365,-0.020346843,0.08746405,0.014461536,-0.04356996,-0.014986479,0.022886239,0.01623885,-0.022424083,0.0075286427,0.016454736,-0.0697726,-0.059179276,-0.0116810305,-0.0048313104,-0.08905037,-0.044514794,-0.083477184,-0.016443966,0.008890583,-0.11148933,0.07562961,-0.08179312,0.047510445,-0.01309494,-0.01161765,0.05024014,-0.02722991,0.027941756,0.10851778,0.046836104,-0.03226698,-0.046414517,0.0053778216,-0.030621182,0.011409948,-0.018079313,0.05435244,-0.024498126,0.02548582,-0.07666708,0.08103708,0.06539347,-0.01011879,0.050233487,-0.010633884,0.012554991,0.043662786,-0.020449221,-0.11139484,-0.043298386,-0.011733552,-0.05370314,0.02635835,0.09490548,-0.046694938,-0.040659346,-0.06192979,-0.031510085,-0.017802693,-0.0012907583,0.0730369,0.00035561886,-0.006242314,-0.04266707,-0.057203893,-0.062895834,0.017244963,0.06068342,0.02456267,-0.02492873,0.016807215,-0.123187,2.0742906e-33,0.12962247,-0.039850693,-0.036438446,0.06673125,-0.011688133,-0.03573633,-0.06130357,0.034928974,-0.0026476462,-0.06213039,-0.103293106,-0.069056004,0.01732778,-0.047565714,-0.0497772,-0.049275804,-0.06513955,0.005602041,0.08021241,-0.0037109863,-0.031808667,0.026176728,-0.06704783,0.023622392,0.00444258,0.09957065,-0.020381568,-0.058551326,-0.01207479,0.0092611285,-0.030453976,-0.116965614,-0.06126699,-0.03481792,0.013329027,-0.03190336,-0.025961902,-0.03291604,-0.083440006,0.06854943,-0.015870087,-0.06851512,0.055245657,-0.09940339,0.082104966,0.01776446,-0.07956524,0.022477826,0.03617591,0.08364798,0.0121866455,-0.047796156,0.119443394,0.05930457,-0.057162423,-0.01710028,0.0032780692,0.04744748,0.02355349,0.077891156,0.077607684,0.12693495,-0.030375576,0.059054468,-0.0059242463,0.057277657,-0.072055936,-0.036410954,-0.0055330186,0.12090741,-0.0115559725,-0.05094241,0.08739453,-0.0016878054,0.09038304,-0.021402216,-0.020655502,0.027202811,0.0028145688,0.020265862,0.054398466,-0.014161875,-0.047181066,-0.03693051,-0.046783313,0.0025748007,0.016897663,-0.021935804,-0.019506117,0.049684104,0.049020458,-0.057622146,0.016264642,-0.025756659,0.047454573,-2.264049e-33,0.079069756,-0.043067425,0.026843136,-0.06451197,-0.0008865751,0.047076352,-0.028900867,-0.00038093512,-0.022838624,0.012512473,0.053112056,-0.027158821,-0.024979437,0.0055398964,-0.03088284,-0.0020561481,-0.0037315807,0.010243973,0.0047179167,0.04830112,-0.0025963574,0.020880017,0.052998684,0.060473256,0.065717466,0.031018399,0.07753117,-0.005800723,0.023227708,0.041292083,-0.048821956,0.028974151,-0.033121206,0.007664383,-0.046754252,0.05410822,-0.018902324,0.0038224168,0.000736494,0.050601617,-0.069389805,0.036757912,0.048379,0.04834859,0.049259372,0.09159683,-0.066144645,-0.042679355,-0.03686128,-0.006025965,0.08157439,0.064509556,-0.010244112,0.041127626,-0.011591241,-0.0002544,0.004237898,0.049685653,-0.0053731627,-0.012903095,0.015651487,-0.08012258,0.0069424817,0.07526424,0.029704873,0.09138158,-0.019620718,0.093574174,0.009424606,0.025815677,0.06779959,-0.045758758,0.07564036,0.09859751,0.011691462,0.019674296,0.02197771,0.0057109627,-0.030602321,0.023747202,-0.027867207,0.026263047,-0.03150422,-0.081005745,-0.04621793,-0.105435394,-0.07077606,0.066602014,-0.0016457281,-0.01503686,-0.034205884,0.07847868,-0.064374305,0.04864984,0.104669206,-4.4343913e-08,-0.01881031,-0.11343522,0.074202284,0.013677585,0.09083256,-0.0013461923,0.016146408,0.049686354,0.081935905,-0.024509229,-0.040515292,0.093781695,-0.001794825,0.021203138,0.05087564,-0.007157339,0.04948533,0.0032826234,0.013194511,0.025300177,-0.047850363,0.018148622,-0.07398281,-9.847415e-05,0.033106536,-0.08556348,-0.02930067,-0.016097873,0.07431476,-0.016095195,0.05448592,0.070037745,-0.021648543,-0.016395222,-0.0419043,0.02098332,-0.03407916,-0.049640123,-0.06864661,-0.014907223,-0.08368748,-0.015374143,-0.034137238,-0.023431407,0.019571114,-0.0091191325,0.06769859,0.04811685,-0.018341605,-0.02801453,-0.0047980836,0.00657922,0.021521607,-0.08768136,-0.1243512,-0.0011510239,0.05016684,-0.03693565,-0.016452095,-0.07201958,-0.050838515,0.0109622115,0.19282793,0.0010568545 +1.14.15.27,The bacterial cytochrome P-450 enzyme is involved in the biosynthesis of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex.,384,0.99999994,-0.1157913,-0.012563679,-0.0194207,-0.038917676,0.00048808558,0.05815674,-0.06282337,0.10693493,-0.067434885,-0.025373815,-0.061626807,0.027781414,0.06459581,0.039314456,0.008732773,0.071186304,-0.08006616,-0.023596443,-0.0041992976,-0.048914555,-0.030645533,0.04951624,0.028568914,-0.04069472,0.02009668,0.056538176,0.05080324,0.08675057,-0.053603735,0.008981708,-0.013036725,-0.01328889,-0.021725804,-0.050654206,0.019090183,0.062374584,-0.09695096,-0.05743484,0.08316461,0.00046451544,0.065100625,0.022321526,-0.06828134,0.07464263,0.027996544,-0.033511788,-0.061764523,0.09003978,0.057667807,-0.029086621,-0.0619905,-0.00649937,-0.03653425,0.048028518,0.043511126,-0.0040938836,0.034597546,-0.041368626,0.018726386,-0.04718423,-0.014327372,0.01743595,0.018433243,0.023922222,0.005767081,0.04323267,-0.018127784,-0.026952645,0.0051451763,-0.01899276,-0.074581966,-0.07470752,-0.07031072,0.052887894,-0.104480796,0.040798638,-0.031000286,-0.022660678,-0.06069832,0.06335082,-0.042011824,-0.048866,-0.027313165,0.053523183,0.054335658,-0.015883008,0.06860501,0.015029701,0.0054153525,0.039830837,-0.035833906,-0.03497942,0.0050568995,-0.027626777,-0.10978995,0.0025045834,0.03168899,0.04775197,-0.015074155,-0.037339773,0.06068549,0.025246615,-0.003850183,-0.075487494,-0.037742835,-0.0046293647,0.018460026,0.0597965,0.0066878046,-0.070224844,-0.04457008,-0.024382068,-0.0012359527,-0.050533727,0.0009100297,0.0937366,0.08033887,0.008298594,-0.086487204,0.02605985,-0.0012687069,-0.060982507,0.010293023,-0.012703566,-0.099826165,0.026482608,-0.11875756,7.3493344e-34,0.066014946,-0.040745944,0.021423664,-0.0068127434,0.078304864,0.0007448921,-0.11391011,0.039766226,-0.05523791,-0.033943012,-0.0820805,-0.06752885,0.011240689,-0.028578416,-0.08187481,0.07057668,-0.020938559,0.02705226,0.06401659,0.056062177,-0.004481642,-0.0017701634,-0.0088108,0.0014557999,0.018023698,0.1311417,-0.02961084,0.03638959,0.0038824491,0.012631017,-0.009395234,-0.08206863,-0.07193036,-0.07296439,0.026167076,-0.04884674,-0.027471673,-0.030901121,0.026987558,0.01029461,-0.03505721,-0.07081762,0.017242987,-0.031333376,0.06679393,0.05152013,-0.03494879,0.020008018,-0.023261705,0.02386261,0.04794779,-0.036704198,0.050766375,0.05360177,-0.0023909537,-0.014121035,0.019716173,0.057971265,0.001402805,0.0723312,0.09264147,0.05193939,-0.012165161,0.09930412,0.009901262,4.2439286e-05,-0.004983227,0.03128125,0.026550338,0.068688914,-0.025858283,-0.0072481157,0.025282476,-0.032781437,0.093843155,0.015875537,-0.0019333696,0.01934455,0.023024637,0.0070423144,-0.016151693,-0.006110352,-0.035351176,-0.043779943,-0.00789079,-0.007940141,0.009682948,-0.0075833043,-0.03807336,-0.01440162,0.055317257,-0.04673401,-0.026345279,0.03446683,-0.036028594,-2.5429067e-33,0.059896164,-0.12912881,0.05781977,-0.13881324,-0.067101575,0.007301034,0.019028908,-0.049242634,-0.00806306,0.028904244,0.041474286,-0.030423472,-0.03322989,-0.01630946,-0.050456535,-0.008201654,0.029666938,0.08751376,-0.0376561,0.024097329,0.07052659,0.055490702,0.06174435,-0.033379987,-0.021136539,0.04586955,0.05357173,0.014335997,0.09453785,0.04699847,-0.086417034,0.10213079,-0.017750967,-0.09267934,-0.068153106,0.026667194,-0.022688596,0.0042928904,0.06735589,-0.010386234,0.018080564,0.06818918,-0.060420632,0.01859162,0.015881272,0.053785186,-0.05164743,-0.027122369,-0.0049505276,-0.049142536,0.07166118,-0.019386424,0.036923695,0.019192567,-0.013777825,-0.007509284,-0.022691976,-0.017936477,0.03954982,-0.038812988,-0.03737075,-0.038003158,-0.01592011,0.030763539,-0.012606639,0.11337294,0.026925404,0.037048202,0.070474155,-0.051639557,-0.03624776,-0.037284777,0.036374595,0.112124234,-0.004417282,0.036199205,-0.042422038,0.040257312,0.044252064,0.070610195,-0.0457374,0.010520119,-0.0688367,-0.054927144,-0.037494212,-0.112414666,-0.041281544,0.10671347,0.034034427,-0.006573137,-0.019049905,0.1126416,-0.0823255,0.06233649,0.035479147,-2.6031039e-08,0.03741986,-0.054194752,0.10412877,0.023456272,0.057091765,0.009069198,-0.010807773,-0.0016217504,0.1009238,0.019003386,0.07241475,0.043656606,-0.013456911,-0.022141071,0.03994453,0.027610073,0.0016256368,-0.03885463,0.047339972,-0.010302934,-0.045297295,-0.008286792,0.020056468,0.057169754,0.02383677,-0.12070407,-0.0060431436,0.002719017,-0.015853709,-0.009318083,-0.019353611,0.02903866,-0.088256836,-0.07918072,-0.06686018,-0.023826046,-0.04016947,-0.067619324,0.05657751,0.012039405,-0.032540053,-0.08188546,-0.0662942,0.021609018,-0.0073415707,0.0060663163,0.0144082215,0.05558611,-0.01202296,-0.061940264,0.015470839,0.008787812,0.014247252,-0.10891945,-0.11051764,0.088704,0.049820974,-0.056617487,-0.103523895,-0.06755943,-0.0018072065,0.000922908,0.1543879,-0.074004106 +1.14.15.28,"This cytochrome P-450 (heme-thiolate) enzyme, found in several bacterial pathogens, is involved in degradation of the host cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol. The products are exclusively in the (25R) conformation. The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.15.29, cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]. The enzyme can receive electrons from ferredoxin reductase in vitro, its natural electron donor is not known yet.",384,1.0,-0.06884462,0.0031057966,-0.08871959,-0.010233595,0.009367849,0.032474294,-0.1009788,0.06449559,-0.023598984,-0.04563496,-0.020358508,-0.012379223,-0.00940856,0.014812562,-0.03129745,0.037922226,-0.09439885,-0.028046852,0.032355964,-0.004117916,-0.054162875,-0.029753014,-0.0051882695,-0.015064476,-0.045825906,0.027113544,0.050325092,-0.025366597,-0.09955183,-0.07491755,0.032142464,-0.021932228,0.072007366,-0.024646353,-0.02708389,0.031064147,-0.042372055,-0.050922215,0.06773404,-0.034266375,0.03897012,-0.04201558,-0.025728354,0.009553336,0.0047210734,-0.077094436,-0.022349296,0.045259938,-0.0036485428,0.011066189,-0.029608693,-0.045338362,-0.04480342,0.01752491,0.027651245,-0.005543327,-0.0051102964,-0.054147687,0.0128568495,-0.02149249,0.034782216,-0.0029968284,-0.0061606513,0.0066652973,-0.08268386,-0.116356514,0.01874592,-0.042898364,-0.03548295,-0.07989435,-0.06586748,-0.08959309,-0.050100733,0.0014213374,-0.028553044,0.08926912,-0.000508652,-0.08479552,0.031915564,-0.012490595,0.0149388425,-0.013190782,0.016001727,0.12530139,0.07399192,-0.010076241,-0.021715354,0.019794999,-0.034639705,0.026368631,-0.00555242,0.013649207,-0.04618729,-0.011381552,-0.06134516,-0.001283954,0.073080085,0.05853844,0.006554791,0.0116969505,0.02694322,0.059121426,-0.015961278,-0.10911554,-0.057686318,-0.036027163,0.053305477,0.10747188,0.050361373,-0.01294648,-0.020446807,-0.034267034,0.02282186,-0.056297958,0.012566672,0.19549765,-0.024727885,-0.05809083,-0.053491186,0.036053218,0.020109005,0.016577102,0.017843707,0.02273534,-0.029037433,-0.011305333,-0.028514743,2.0696861e-33,0.043904718,-0.018069072,0.014703588,0.043026164,0.02118237,0.059938475,-0.05357402,0.00433729,-0.010380827,-0.042614322,-0.00630362,-0.08803378,0.086653985,-0.042287257,-0.04542832,0.0051194374,-0.055994432,-0.00894377,0.018832866,0.027022507,-0.02028255,0.009472243,-0.0789469,-0.010629801,-0.0006553787,0.030606298,-0.0059673525,0.042448003,0.0066629346,0.025912115,-0.008130203,-0.047600154,-0.08935207,-0.044489577,0.040659577,-0.002458796,-0.05778053,0.014073314,-0.06640714,0.052802812,0.039529026,-0.012020536,-0.0011219521,-0.07025095,0.08631335,0.004926285,0.0049844845,0.10881554,0.0077265496,0.062931,0.033970695,-0.033462267,0.06455871,0.0360316,-0.00331646,0.10359204,0.004687187,0.034570064,0.033049285,0.02798564,0.1559941,0.07550418,-0.05625042,0.033890788,0.025868272,0.02600622,-0.011872068,-0.06954683,-0.08742843,0.14444467,-0.007537966,0.05777667,0.027145125,-0.033584308,-0.0051548947,0.0120171495,-0.029842999,0.06732453,0.069825344,-0.08550984,0.016259681,0.015451073,0.018738637,-0.07544145,-0.0070611727,0.015241159,-0.04155341,-0.016562901,-0.030143052,0.08776703,0.038418967,-0.13690986,-0.088778764,-0.0011002488,-0.050499674,-2.2605126e-33,0.04999165,-0.05219778,0.013698697,-0.106766865,-0.034811657,0.07414149,0.053466402,0.046572648,0.04861368,-0.032260332,0.10112149,0.028146194,0.032983545,-0.021739352,0.07465393,0.034250397,-0.078291886,0.0054805507,-0.020583134,0.008187592,-0.0010731565,0.042549215,0.0072579468,0.08732069,0.03345625,0.07509182,-0.0009257637,-0.037128333,0.13461022,0.041899774,-0.03447095,-0.013655997,-0.018202016,-0.04737146,-0.066455565,0.08469421,-0.020377932,9.576983e-05,0.044527438,0.009081106,-0.077460624,0.026772536,0.019566642,0.013992702,0.020208683,0.09432489,-0.07264842,0.02439399,0.059220415,-0.037893213,0.018300729,-0.021447558,-0.0216693,0.057594914,-0.026831618,0.07100579,0.04569149,-0.0014180532,0.02827502,-0.13167512,-0.07095438,-0.014232787,0.03598216,0.025185956,-0.01068761,0.042385362,-0.029587233,0.0691161,0.04850954,-0.013237104,-0.017168673,0.053720046,-0.026765037,0.029266536,-0.00012389441,-0.026210079,0.022808004,-0.019288419,0.0090984665,-0.0038211218,0.011006765,-0.006229204,-0.017055117,-0.07257188,0.0087896185,-0.15742478,-0.008886074,0.06710027,0.052082725,0.03092769,-0.01207567,0.025430191,-0.08285772,0.070357904,0.030518409,-4.411471e-08,-0.0037475016,-0.103638284,-0.009292781,0.026645305,-0.01733198,0.013901931,0.03691328,-0.0028658812,0.06849832,-0.0281102,0.00044954038,0.13651367,0.021042585,-0.014010447,0.01534535,0.015299453,-0.046693668,-0.01745671,-0.0063659605,-0.008591201,-0.017008156,-0.029540617,-0.0037498788,0.057136368,0.009082708,-0.04065643,-0.01049925,0.010265179,-0.005826901,-0.030303104,-0.027146684,0.059108645,0.007497223,0.02085339,-0.010270152,0.0037748988,-0.077522114,-0.05582447,-0.0076033664,0.09258633,0.023933196,-0.04678145,-0.070216216,-0.02423167,0.01715075,-0.030507272,-0.037116304,0.08148187,-0.0041608056,-0.021358965,-0.06581327,0.046676047,0.005358614,-0.01742146,-0.07011258,0.0632216,0.015350721,-0.07922654,0.032179657,-0.076369435,0.031210158,0.026093408,0.24118458,0.04666283 +1.14.15.29,"A cytochrome P-450 (heme-thiolate) protein found in several bacterial pathogens. The enzyme is involved in degradation of the host's cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol [4]. The products are exclusively in the (25S) configuration. The enzyme is part of a two-component system that also includes a ferredoxin reductase (most likely KshB, which also interacts with EC 1.14.15.30, 3-ketosteroid 9alpha-monooxygenase). The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.15.28, cholest-4-en-3-one 27-monooxygenase.",384,1.0,-0.060150202,-0.033100072,-0.05922607,-0.025113286,0.01389111,0.07230653,-0.108208396,0.09215329,-0.01547634,-0.06318048,-0.026651919,-0.014589421,-0.0065222974,0.030167503,-0.040925354,0.023776377,-0.09549484,-0.020247832,0.02988276,-0.010577227,-0.041290354,-0.024893947,-0.021288734,-0.007888195,-0.07763316,0.044730447,0.064428195,0.005220238,-0.11722209,-0.09404744,0.014800863,-0.034740333,0.07831395,-0.013858785,-0.0027877507,0.046350993,-0.0461692,-0.040817186,0.04397376,-0.03848801,0.04131095,-0.019087046,-0.010784289,0.025333852,-0.00043818288,-0.063293524,-0.04198547,0.05528606,-0.0047235056,-0.011108071,-0.03747231,-0.053929944,-0.033123758,0.05170026,0.04429018,-0.0061591216,-0.031030381,-0.04818699,0.018044857,-0.048269574,-0.00719936,0.017228926,0.00683021,-0.0034830815,-0.035693362,-0.09166023,0.011530174,-0.043005366,-0.041793715,-0.043399304,-0.07506291,-0.09161627,-0.06541734,0.01764597,-0.034133423,0.07954835,-0.015746327,-0.07223657,0.012006557,-0.029537568,0.02213995,-0.002609324,-0.004671545,0.11836315,0.0888779,-0.033004686,-0.032887492,0.0068799243,-0.05376249,0.015030066,0.021819431,0.01097164,-0.00016361706,-0.022270983,-0.05366366,-0.0072826506,0.049504366,0.04030305,0.016914688,-9.53091e-05,0.014822465,0.05274269,-0.006581203,-0.10333744,-0.05250106,-0.01764438,0.018922187,0.08899518,0.04657022,-0.028252311,-0.027304266,-0.018646618,0.029819822,-0.053978655,0.038641013,0.14492632,0.027366996,-0.052800763,-0.043876708,0.03336181,0.023943963,-0.009387978,0.0537831,0.021916544,-0.047835205,0.007599628,-0.059594344,1.752035e-33,0.03160342,-0.05108551,-0.0004172877,0.025043624,0.017409416,0.012300011,-0.06011134,0.03313229,-0.0014342832,-0.034669057,-0.013962274,-0.06698609,0.07960061,-0.014896049,-0.035155132,0.011622324,-0.04670492,0.017059797,0.0084960945,0.017310062,-0.047999863,-0.0011848935,-0.058893297,0.0011684926,0.02171992,0.03564647,-0.017838532,0.050224096,-0.014227908,0.012173891,-0.02847187,-0.048866857,-0.107686624,-0.020154662,0.033602312,0.01576792,-0.036937192,0.021193456,-0.08246694,0.060909603,0.007198284,-0.037964176,-0.03027795,-0.07572885,0.106204055,-0.024833973,-0.05460091,0.11752181,0.024665307,0.057596702,0.06397029,-0.060058955,0.09338446,0.04607988,0.0010615747,0.10431671,0.01826856,0.015653335,0.013822858,0.06103572,0.14016135,0.092217304,-0.07829793,0.01875871,0.030083723,0.051165648,-0.04320332,-0.071744,-0.07832017,0.13598981,-0.012064354,0.06386196,0.05448324,-0.016298475,-0.0029623539,0.008847453,-0.05571671,0.076887876,0.051416107,-0.02972075,0.015569435,-0.010798793,0.010583263,-0.06463499,-0.021028044,0.0042802733,-0.032146007,-0.03319493,-0.041701015,0.05740431,0.059710983,-0.11266708,-0.085883446,0.03178502,-0.029969655,-2.568693e-33,0.04877486,-0.060586654,0.033933345,-0.11280183,-0.019894503,0.09666073,0.065924704,0.02159048,0.042837832,-0.057022233,0.07420163,-0.011291399,0.03286479,-0.008731066,0.08348333,0.06527726,-0.0798628,0.03222784,-0.018646823,0.0032868355,-0.01129378,0.05855432,-0.005927997,0.10590514,0.020287655,0.058125757,-0.017294614,0.026536722,0.10982856,0.037396282,-0.024746701,0.00072214915,-0.042920534,-0.0495096,-0.07177651,0.07799218,-0.05846058,-0.014258209,0.03512668,-0.0015827732,-0.031219544,0.06785903,0.0015007402,0.026824614,0.046382017,0.11667013,-0.07402071,0.0034836195,0.0496582,-0.06155344,0.0049831765,-0.018058848,-0.008435104,0.06618719,-0.04450383,0.07827752,0.04112505,0.021899993,0.045770735,-0.08871458,-0.067135684,-0.02476494,0.012380901,0.05885757,-0.014541492,0.0117064975,-0.019332986,0.037139162,0.051558487,-0.011306483,0.013443072,0.06849108,0.012870607,0.047632493,0.011218015,-0.01172072,-0.0077498793,-0.0093990825,0.033733513,0.0087239435,0.01606466,0.0104923155,-0.005936056,-0.055639118,-0.014079982,-0.11761242,-0.038505115,0.051633384,0.059342656,0.0022313127,0.0152848065,0.027225444,-0.09390716,0.066522025,0.03698344,-4.961179e-08,0.06686532,-0.098774984,0.01024129,-0.004953863,-0.0040089046,0.01878163,0.047293413,0.013162977,0.067931764,-0.038382933,0.0071551213,0.14255498,-0.005159567,-0.029657034,-0.0036431737,0.032557804,-0.051076174,-0.040225126,0.014614361,0.009131481,-0.029275497,-0.034738544,0.0017363124,0.06695422,0.0111810025,-0.05408709,-0.010831238,0.041484006,-0.0029137023,-0.027067242,-0.016748276,0.05835037,-0.026193833,0.020343166,-0.013354816,0.018725049,-0.05934849,-0.05577306,-0.007914017,0.09363771,0.004607447,-0.05228892,-0.09542886,-0.04957572,0.039502,-0.016880233,-0.031041827,0.05563777,-0.011855086,-0.040440135,-0.065014094,0.0465373,-0.016018318,-0.01114371,-0.09287348,0.031455234,0.023828335,-0.08438749,0.001150332,-0.07672529,0.03598016,0.04820182,0.24198732,0.02846504 +1.14.15.30,"The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It forms a two-component system with a ferredoxin reductase (KshB). The enzyme contains a Rieske-type iron-sulfur center and non-heme iron. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.",384,1.0,-0.054097764,-0.058665458,-0.11704386,-0.002697476,0.070267044,0.058772694,-0.04264323,0.08080099,-0.009235308,-0.08592778,-0.066591665,-0.024532368,0.024548953,-0.009011727,-0.054375734,-1.6301556e-05,-0.06554479,-0.020262348,-0.011553371,-0.0006540638,-0.025002008,0.020507818,-0.019668372,-0.04112133,-0.028654007,0.00017752049,0.09895312,-0.063869655,-0.11342379,-0.108495764,0.028507032,-0.04467865,0.020760292,-0.03002063,0.026655605,0.07366676,0.010567598,-0.030334348,0.03088134,0.03407107,0.020583645,-0.020352092,0.01842866,-0.023551669,0.0013631757,-0.017214872,-0.059499234,0.021469792,0.050401237,0.037814885,-0.077272095,-0.05998562,-0.039945636,0.09335378,0.09422094,-0.01955932,-0.03679455,-0.0262055,-0.0073497603,-0.015125562,0.07919316,-0.014044311,0.018868212,0.026585698,0.005243747,-0.018753275,-0.0016811844,-0.0651224,-0.018377688,-0.07392091,-0.06421167,-0.04752642,-0.119536504,0.036077604,0.031632744,0.035111032,-0.0049760654,-0.03269184,0.047698226,0.010775512,-0.005687347,-0.0035994162,0.02216549,0.09680599,0.05889379,0.018629123,0.004158588,-0.032784365,-0.03064277,0.02732128,0.050844908,0.009215919,0.016161304,-0.017087901,-0.07443427,-0.0153554855,0.01513231,0.024303501,-0.0102961315,0.007965574,-0.03172697,0.05485812,-0.0024385788,-0.07544158,-0.036997534,-0.02200299,-0.030469524,0.09445216,0.039456308,-0.007476057,0.0052191843,0.007139734,0.05553502,-0.03603684,0.010264781,0.09624133,0.08581354,-0.055824377,-0.094079465,0.047699116,0.091794595,-0.01359064,-0.00023241417,0.03170178,-0.08395698,0.002989884,-0.07785441,-6.4588993e-34,0.03515477,-0.05034361,0.044397637,-0.031172555,0.0077414224,-0.015197566,-0.11984832,0.007694089,-0.015962036,-0.050160192,-0.013144473,-0.07744048,0.035963174,-0.018380791,-0.073442236,-0.035551272,-0.028657155,0.004629892,0.061538897,0.009192132,0.027840463,0.06569136,-0.024625268,0.030794472,0.01608474,0.067828946,0.0008154252,0.056888893,-0.021626053,0.0030123699,-0.0009840747,-0.074036,-0.12583162,-0.016802592,0.0037220444,-0.0075045684,-0.061663322,-0.009244698,-0.013019336,0.07916569,0.0130454935,-0.025294289,-0.0201562,-0.03726924,0.10733277,-0.062436186,-0.049527165,0.09270153,0.040265728,0.040048752,0.026391989,-0.044310983,0.0820547,0.062390756,-0.0040906942,0.045853943,0.035417568,0.030638615,-0.001612953,0.022841832,0.096841075,0.06742801,-0.049475618,0.067417674,-0.019634876,-0.024290867,-0.04464715,-0.03651569,-0.025942907,0.063121006,-0.018720454,0.0787564,0.040693574,-0.013528471,0.05437035,-0.04868289,-0.09236493,-0.007473401,0.057682175,-0.05553581,0.0021622775,-0.047687817,-0.002552103,-0.04326811,-0.049939755,-0.024326133,-0.06750496,-0.047558136,-0.06736979,-0.009448656,0.05010342,-0.047952954,-0.13091938,-0.006752717,-0.026812755,-2.470362e-34,0.051012374,-0.097840115,0.031205267,-0.06791797,0.020236034,0.041936517,0.0837518,0.023874674,0.022522131,-0.0013424156,0.08335276,-0.018602815,0.006537105,-0.06448109,0.09426366,0.080600895,-0.0062128347,0.026193988,-0.00011149121,-0.0280126,-0.028587008,0.06633844,0.025187472,0.06261481,-0.008248312,0.028343132,-0.030188425,0.04931424,0.11826538,0.11611534,-0.008256498,-0.01688451,-0.047689583,-0.034807246,-0.13617317,0.027403085,-0.07399805,0.0053090975,0.06382829,-0.03914727,0.0014851299,0.049870025,-0.0065013357,0.030058293,0.060526025,0.09001917,-0.06949497,0.06430613,0.060862225,-0.048246592,0.0021374489,-0.009782419,0.030508177,0.05556174,-0.029036904,0.08002477,0.035492633,0.019000083,0.008180722,-0.024357332,-0.07028847,-0.030264799,0.03903339,0.03366691,0.046198513,0.07259317,-0.008201653,0.052824248,0.05483711,-0.0066398513,0.07284958,0.0537367,0.044271853,0.04422082,0.007128416,-0.072777145,-0.043291092,0.07194554,0.0006447754,0.01893386,-0.03556954,0.035274,0.002007279,-0.0663647,0.01919211,-0.11341361,-0.011051269,0.075540066,0.05452608,0.014117723,-0.02761755,0.025833476,-0.09839876,0.03451928,0.060333375,-3.9367603e-08,0.056142893,-0.12532616,0.022828218,-0.050608624,0.00841106,-0.01726375,0.03867521,-0.0016247978,0.037669327,-0.022908429,0.027721684,0.17652579,0.0055757025,-0.05431658,0.06562372,0.045828845,0.006245841,-0.00039259234,-0.0052956026,-0.023099583,-0.010761376,-0.03461489,-0.05108913,0.04479111,-0.0111544635,0.00073370483,-0.01961101,0.040782608,0.014788083,-0.025482664,-0.0216875,0.04565502,-0.0015468256,-0.021438373,-0.12225988,0.026300197,-0.06862236,-0.015261921,0.035591103,0.046927962,-0.022583952,0.011151518,-0.07990281,-0.0034804402,-0.008638336,-0.017885096,-0.039197173,0.042400338,0.022475159,-0.050505094,-0.016788434,0.017965298,-0.04244149,0.010878764,-0.08635748,0.07635474,0.0057785367,-0.04860327,0.012937889,-0.037162434,0.009267293,0.03651501,0.20980144,0.008169179 +1.14.19.61,"The enzyme, characterized from the bacterium Bradyrhizobium elkanii, catalyses the final step in the biosynthesis of the nodulation enhancer compound rhizobitoxine.",384,1.0,-0.07736411,-0.0200195,-0.119042985,-0.005017297,0.043085165,0.029668467,-0.077700175,0.06282846,-0.040522207,-0.035444032,-0.018237947,-0.05982293,-0.03514993,-0.01854199,-0.056569338,0.017995331,-0.0974272,0.059909016,-0.022131292,-0.061155885,-0.02076597,0.071109526,-0.023972856,0.0048409915,0.08044046,0.047224328,0.049781673,-0.0060732383,0.018793933,-0.07149174,0.07223866,-0.022369092,0.14013945,-0.108432025,0.074740976,0.07423192,-0.068415955,-0.044383988,0.07146183,0.017239235,0.018364197,0.00079985353,0.068395995,-0.064608596,-0.037598114,-0.0124547435,-0.018085513,0.032472573,0.12580417,-0.026424045,-0.09213276,-0.03212809,-0.04442655,0.06079303,0.018408263,0.038631033,-0.014583608,-0.04911752,-0.016714683,-0.0024809767,0.008825952,-0.051112887,0.059162773,0.014589467,-0.06349592,-0.00056462793,-0.02833502,-0.08235378,0.010970701,0.021940323,-0.063408114,-0.02331641,0.003572544,-0.0081369,-0.034834895,0.0015123463,0.019759394,0.030656923,0.06289822,-0.011805928,-0.023790522,-0.06566832,0.044869274,0.033034995,0.037566673,0.045491498,0.00371208,-0.05653646,0.052640077,0.09261076,0.032672822,0.04073312,0.0049364604,-0.060098447,-0.044852156,0.011808775,0.019545885,0.0014671905,-0.0028662845,0.0132998405,0.021530425,0.026128953,-0.08682677,-0.1392429,-0.0480263,0.024937741,-0.019689621,0.07107663,0.006419762,0.03686126,-0.00476035,0.0017719073,0.017929444,0.013937222,0.014730795,0.04790813,0.032535143,-0.041782998,-0.052412406,0.0033577378,0.03816745,-0.04244901,0.04263558,-0.04852139,-0.015333441,-0.038147457,-0.112061806,2.8274623e-33,0.08736759,0.11295793,-0.083311655,-0.054737896,0.011418136,0.013955992,-0.11646141,0.027442794,-0.06580507,-0.07034491,-0.081454836,-0.022549689,0.02133368,-0.013725755,-0.018723404,-0.00066183496,-0.08435838,0.015841769,0.035633538,0.03704103,0.04929597,-0.017309675,-0.092935696,0.037907265,-0.032866225,-0.00012892371,0.037075903,0.024470402,-0.052109223,0.00048020948,-0.0100707,-0.0059983963,-0.08223953,-0.028003227,0.087910645,-0.016237196,0.03106948,-0.020606926,-0.039986186,0.07340755,-0.010620734,0.045431156,-0.040846694,-0.00047041776,0.07946109,-0.037910786,-0.03890617,0.12556867,0.07313455,0.082152605,-0.0109233735,-0.031611532,0.16206232,0.011995243,-0.032131076,-0.0062695644,-0.08004293,0.017972294,0.027319549,0.023308892,0.031005222,0.022679549,0.034037482,0.035963565,-0.0016456641,-0.00038201784,0.05102052,-0.04063683,0.047327958,0.028652983,-0.01729334,-0.03542515,0.06823117,0.05585998,0.006928656,-0.06779975,-0.082860485,0.011071725,0.05125399,-0.011103295,-0.02001467,-0.003465594,0.008392441,-0.032031465,0.015723938,-0.0071461294,-0.0080033075,0.01605625,-0.052538224,0.008963249,0.12731546,-0.108772025,-0.06429416,0.03019763,-0.0039033408,-2.3275284e-33,0.17392094,-0.06311688,-0.026095662,-0.021888476,-0.027229087,-0.019574728,0.054259285,-0.045553725,0.032967933,-0.06543542,0.09223514,-0.0088752145,0.07374341,-0.028974384,0.027346313,-0.06492177,0.06345402,0.026353613,0.01786215,-0.0236964,0.077069275,-0.03806336,0.01018469,-0.054009434,0.029387256,0.015007785,-0.06521711,0.108035035,-0.00029909884,0.063718766,-0.020679856,0.025601981,-0.104541585,-0.08315967,-0.023143373,0.13496709,-0.028994929,-0.017747534,0.012414537,-0.049353015,0.060022105,0.007707025,-0.10475178,0.090876505,0.022250159,0.026316207,-0.06546001,0.056152157,-0.023987977,-0.06592977,-0.0074107354,0.013778279,0.06075578,0.043394733,-0.0411096,0.026799735,0.0033165282,0.0015335177,-0.01374986,0.067755364,-0.020273168,-0.017645095,0.0021964742,0.03153288,-0.011143559,0.070818655,0.03131934,0.0568357,0.041922018,0.016926821,0.068007424,-0.018514797,0.102343835,0.13671143,-0.018847354,0.006389185,0.03855133,-0.044623617,-0.023147283,-0.006355487,-0.017513225,-1.9971065e-05,-0.0048263944,-0.029538294,-0.055315476,-0.054377392,-0.021543195,0.05277324,-0.03768364,0.025615258,-0.016733738,0.01717842,-0.06437175,0.038006548,0.019248486,-2.9902488e-08,0.0179515,-0.08779922,-0.0142139215,-0.086433545,0.09572627,0.06477545,-0.00902771,-0.01734792,0.009613652,-0.1003868,0.02216907,0.07086858,0.03065311,-0.018778041,0.076893575,0.03883062,-0.041318104,0.037640486,-0.036786407,0.018705636,0.020197358,-0.0033690014,-0.07617363,0.0058597387,0.02394334,-0.028190225,0.01738709,0.007273107,-0.032701947,0.001766816,-0.00041514862,0.04468263,0.08466303,-0.020818973,-0.031734787,0.048974782,-0.02875847,-0.024794038,-0.0068749534,-0.06206185,-0.017123263,-0.019713636,-0.07806852,-0.048836958,0.0042303028,0.008207627,-0.040663224,0.005185305,0.0106871035,-0.091263734,0.028239843,0.0017506342,0.037130184,-0.022494536,-0.04388064,0.024485318,0.024052199,-0.056943852,-0.018892664,0.02790418,-0.06423481,0.021330792,0.13087855,-0.065215036 +1.14.20.9,"The enzyme is a member of the Fe2+, 2-oxoglutarate-dependent oxygenases and requires Fe2+. It has been characterized from bacteria that form the isonitrile-functionalized compound paerucumarin. cf. EC 1.14.20.10, L-tyrosine isonitrile desaturase/decarboxylase.",384,1.0,-0.059039984,-0.036671758,-0.106746815,0.044162005,0.059463453,-0.019850569,-0.07815529,0.04464577,0.07077342,-0.042982988,-0.010002366,-0.011095021,-0.13520297,0.06779563,-0.08123392,-0.0074918307,-0.123510145,0.0113245845,0.022370422,-0.02948647,0.066710144,0.07578467,0.0030259339,-0.018588461,0.015626054,0.007603823,0.004734673,-0.04890566,-0.02534588,-0.0699386,0.027369877,-0.09837037,0.025902612,-0.039794996,0.027132668,0.0713604,-0.035634913,-0.06273053,0.022146778,-0.011886921,-0.029301958,-0.055465437,-0.09592005,-0.045027126,-0.038647376,-0.11321615,-0.020089084,0.010614388,0.04127777,0.07397231,-0.026862878,0.022390509,-0.059668403,0.019839399,0.0018581959,-0.084213175,0.02478909,-0.054105975,-0.054388605,-0.013548935,0.07799559,0.012896345,-0.039526325,-0.017113442,-0.0019696786,0.014583161,0.0693974,-0.082151346,0.025805086,-0.038785923,-0.06752013,-0.07174062,-0.012769372,-0.013996392,-0.082184725,0.013964456,0.0319851,-0.045329124,0.07668188,0.02400407,0.08667841,0.052579902,0.037825894,0.10967374,0.012080801,0.025709296,-0.06067971,-0.025051432,0.03359386,0.04042736,0.04339621,0.064949125,0.004966803,-0.005566788,0.036226243,-0.009980635,-0.039702587,0.13219362,-0.025627581,0.010125981,-0.03021948,0.045369547,-0.06404384,-0.097802125,-0.06280163,-0.034956854,0.016589666,0.0057331244,0.070624396,0.014736239,-0.017574169,0.010300726,-0.010785825,0.032662086,0.0012195356,0.10641478,0.028833535,-0.0788962,0.023095004,-0.035003155,0.05916718,-0.03493579,0.03326929,0.080790564,-0.0037129687,-0.021994378,-0.1029169,1.5027638e-33,0.07685716,0.032065075,0.042332947,0.071053855,-0.020690726,0.015627164,-0.053872533,0.003907816,-0.05789139,-0.036850072,-0.12249633,-0.06922077,-0.01059216,0.029908735,0.053545956,-0.0776579,-0.030625623,0.024130879,0.0450037,-0.001863216,0.0269475,0.118061565,-0.031130357,0.004177442,0.047620747,0.071240835,-0.10842048,0.055680126,0.011567013,-0.023616519,0.068899564,-0.10051671,-0.061138697,0.0088119805,0.108365774,-0.01346081,-0.050756235,0.050504316,-0.041739486,0.033952266,0.015076007,0.015086417,0.0030554729,-0.047453504,0.088003345,-0.054549165,-0.08325115,0.1031059,-0.014332625,0.07296152,0.022024618,0.0032963026,-0.0018324185,-0.038677983,-0.0129852425,0.05078951,0.0044663185,0.03335074,0.08841244,0.057079528,0.023395771,0.028025566,0.053018473,0.020937847,0.044117734,0.0014016469,-0.025534984,0.029789217,0.026820498,0.08495944,-0.042808205,0.018542247,0.0929638,0.03939227,0.08644607,-0.039311454,-0.05381266,0.04233434,0.041850816,-0.034785815,0.009081082,-0.036725424,-0.003815462,-0.056404773,-0.07907336,0.00073223544,-0.04359689,0.029458106,-0.03379163,0.06969679,0.03802133,-0.02503304,-0.10252294,-0.0239979,0.036671527,-3.316225e-33,0.079677805,-0.14979021,0.023495574,-0.10853971,-0.08286359,0.09964484,-0.031075237,-0.041395914,0.009430349,0.07605467,0.084515505,0.011010519,0.033204727,-0.057830032,-0.0021449444,0.010883522,-0.008528818,0.021865577,-0.007564538,0.02110841,0.039823752,0.10345978,0.046202824,-0.009538239,0.06614155,-0.026428983,0.026654473,0.053612355,0.022599978,0.002083987,-0.04148802,-0.003824823,-0.008832422,-0.071583375,-0.04058423,0.017133035,-0.014726115,-0.0057340474,-0.02273443,-0.04533804,-0.024666375,-0.008437574,-0.0005499483,0.10199098,0.054063547,0.012306911,-0.057212155,-0.05121483,-0.046953503,-0.0159879,0.030400056,0.0019227824,-0.038934387,0.02386302,0.025691357,0.05100194,-0.015524557,0.019125365,0.012044218,0.059532,0.0053387936,-0.0003875156,0.025817243,-0.0030745314,0.079794645,-0.0023039924,-0.011125568,0.08947488,0.040260296,-0.024858698,0.07033314,-0.00750228,0.022681825,0.041305855,-0.03815029,-0.06609318,-0.03871755,-0.017720748,-0.0010828766,-0.032935362,-0.068386935,-0.036195446,-0.010121531,-0.07905373,0.002541384,-0.044670336,0.053890273,0.10180625,-0.038782686,0.042264674,0.022130527,-0.009727163,-0.059159245,0.023920313,0.0055463426,-4.1564736e-08,-0.041294616,-0.07393192,0.024861574,-0.090128765,0.015337572,0.022725416,0.024469482,-0.02607389,-0.041543964,0.01379891,0.036363263,0.09723704,-0.029345004,-0.021768393,0.034765583,-0.025367985,-0.013770492,0.055371556,-0.010776917,0.013579958,-0.016991448,0.019696318,-0.10567774,-0.024380445,0.022039982,-0.045862645,0.018708147,0.07471904,0.06390277,0.008853512,-0.021522364,0.077390596,0.0016421475,-0.079172626,-0.08166854,0.014142377,-0.013040199,-0.06367613,-0.07849729,0.025352882,-0.022688905,-0.014449202,-0.0049757576,0.0054193097,-0.020991499,0.058018226,0.03312175,-0.0028170706,-0.01970207,0.004921328,0.069738604,-0.042741463,-0.013015826,-0.05099672,-0.10813968,0.04962071,0.021084534,-0.03592627,-0.012941028,-0.019717347,0.02049774,-0.014683884,0.17105757,0.008351233 +1.14.20.10,"The enzyme, characterized from the bacterium Xenorhabdus nematophila, is involved in rhabduscin biosynthesis. The enzyme is a member of the Fe2+, 2-oxoglutarate-dependent oxygenases. It is similar to EC 1.14.20.9, L-tyrosine isonitrile desaturase. However, the latter does not catalyse a decarboxylation of the substrate.",384,0.99999994,-0.04941285,0.0258927,-0.0819495,0.010635681,0.07439682,-0.03222197,-0.03173773,0.061161786,0.030530069,-0.0638468,0.0020194147,-0.07718702,0.039910413,0.0405894,-0.051149555,-0.024635168,-0.06922698,-0.010827435,0.013576432,-0.07421079,0.10074288,0.052497078,0.005630289,-0.022948235,0.03515026,-0.01369218,0.034565654,-0.0694272,-0.048743438,-0.09239771,0.01718391,-0.09525064,0.0778237,-0.06621272,0.032296762,0.10012568,-0.033047598,-0.07285872,0.04747284,0.03854611,-0.041991785,0.010140362,-0.0250776,0.0012130811,-0.044471763,-0.05188795,-0.018154608,0.034296285,-0.012358066,0.025077319,-0.04251089,0.0025934111,-0.034238923,0.044872586,0.07010972,-0.050035667,-0.00044483817,-0.053481475,-0.0767941,-0.016944388,0.12002665,0.025093334,0.020149868,-0.028101964,-0.049369317,-0.040471084,0.044689454,-0.06241046,0.06797961,-0.02040975,-0.08338185,-0.037362427,0.007293602,-0.017563876,-0.018857462,-0.0038491597,0.027941516,-0.0060390695,0.023304477,-0.0088527845,0.01322415,-0.00080757245,0.012206655,0.047278482,0.046606917,-0.007267038,0.018341219,-0.012493508,0.031083342,0.061375458,0.019709738,0.015574658,0.010463091,-0.039102193,-0.04308379,-0.029652944,0.015744736,0.07099796,-0.007065192,-0.00071035296,-0.008138916,0.058915786,-0.034260705,-0.06423143,-0.083088964,-0.041614205,-0.054825325,0.06871928,0.006333215,-0.011728597,-0.031366233,-0.03126478,0.035484467,0.06925984,-0.040077884,0.1331139,0.011635323,-0.052613396,-0.07351908,-0.013707892,0.07623303,-0.038619008,0.005117146,0.06092208,-0.00039137027,-0.019125191,-0.15936473,2.5034959e-33,0.03435633,0.064152144,-0.06393348,-0.012578117,-0.029788747,0.00032241005,-0.103545904,0.07611806,-0.09732452,-0.023800181,-0.05919107,-0.031436525,0.055445924,0.044826433,-0.026701983,-0.07096943,-0.043799605,0.04269719,0.021190198,0.03535516,0.03745979,0.07252057,-0.049687523,-0.022818482,0.039209593,0.045982804,-0.024515897,0.0028259668,0.017775588,-0.005061945,0.023280928,-0.11826579,-0.037851743,0.07251386,0.07608965,-0.014195258,-0.015628109,-0.0433262,-0.037121203,0.014444462,0.0136151,0.060941093,0.031473048,-0.06873289,0.061744936,-0.03077594,-0.024554327,0.08638238,0.056926917,0.069798015,0.03827458,0.00475523,0.12849662,-0.054785047,-0.030700035,0.0069267703,-0.057370797,0.03969353,0.03817027,0.019861488,0.02107906,0.024915662,-0.028141085,0.002784376,0.03360139,0.04422637,-0.029696088,-0.03451845,0.03517156,0.099044286,-0.09840236,0.0341573,0.103319496,0.023221375,0.043302275,-0.032560293,-0.08596634,0.009191027,0.038760476,0.037015006,0.008734735,-0.012379847,-0.011517916,-0.0933394,-0.02984918,-0.018622372,-0.022440737,0.04814193,-0.037477266,0.08648448,0.031953283,-0.08534601,-0.101190634,0.018579798,0.069291286,-2.5538212e-33,0.07896808,-0.105170734,0.031607557,-0.087940045,-0.021007871,0.06859172,0.026944976,0.027555928,0.021086425,-0.024408383,0.07675337,0.019939095,0.042133674,-0.03275707,0.025509728,-0.0191156,0.024770401,0.055161778,0.006895706,-0.002406652,-0.011791983,0.06698258,0.019018807,-0.05025225,0.039387923,0.020571552,0.012511238,0.09452694,0.037440635,-0.022097828,-0.052855223,0.0056542554,-0.03577947,-0.044349577,-0.042079497,0.038633294,-0.058248498,0.012566745,0.039162688,-0.016495323,0.022764344,0.052305665,-0.0037810574,0.08924017,0.056324214,0.0692573,-0.08231174,0.033344835,0.042878162,-0.04238115,0.010161052,0.018706037,-0.022890981,0.00084434025,0.041053634,0.06408827,-0.05294931,0.054131903,-0.015940066,0.042900883,-0.023556465,-0.039764214,0.060022566,0.018403731,0.03303239,0.009187985,-0.050939474,0.08726436,0.03768153,0.020854289,0.13086069,0.007983195,-0.040251836,0.012131304,-0.037788007,-0.085413404,-0.08690701,-0.055631947,-0.02441854,-0.023679947,0.013329891,-0.011267388,0.033820234,-0.04253259,0.018795257,-0.022469606,-0.0010816877,0.12336438,0.048965786,0.0033161684,-0.008950155,-0.035912916,-0.049412254,0.051803723,0.08231525,-4.2531394e-08,0.007170137,-0.0776155,0.031256147,-0.04875616,0.016376588,0.053318802,0.0035405902,-0.05399559,-0.02818329,-0.012810753,0.039341345,0.07254498,-0.05373569,-0.03267506,0.026025636,0.0029744029,-0.043865353,0.08139814,0.0013599757,0.039266232,-0.0047944365,-0.025269864,-0.115036696,0.05245411,0.005819645,-0.038266953,0.04405756,-0.0089942515,0.035185818,-0.08840653,-0.0511231,0.026033388,0.012514358,-0.0050647594,-0.09629757,-0.03892533,-0.07426735,-0.005321862,-0.0043105204,0.004190395,0.062100645,-0.026226865,-0.0498058,0.030840712,-0.011627969,0.058417637,0.00301978,-0.06383729,-0.025528125,-0.019524092,0.060687922,-0.023873061,-0.005892459,-0.07917113,-0.10719471,0.045472976,-0.037106212,-0.05332134,-0.019924665,-0.023127554,0.0041567553,0.016693229,0.26244384,-0.039177686 +1.14.20.11,"The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids. The enzyme catalyses an Fe2+, 2-oxoglutarate-dependent monooxygenation at C-3, which is followed by decarboxylation and dehydration, resulting in the generation of a cis C-C double bond. cf. EC 1.14.20.12, 3-[(E)-2-isocyanoethenyl]-1H-indole synthase.",384,1.0,-0.06602325,-0.04241764,-0.08212955,0.08066487,-0.07225824,0.05847183,-0.06379434,0.016926402,-0.007937408,0.009295217,-0.011394386,-0.07193499,-0.0530771,-0.0389641,-0.061477497,0.07618708,-0.09477363,0.07824021,0.043966055,-0.013147213,0.06578922,0.024054997,0.018834163,0.0045883814,0.045796104,0.005198244,0.056743946,-0.023549445,-0.061772242,-0.059399735,-0.007538156,-0.061421566,0.06664538,-0.04282461,0.07744474,0.0135732675,-0.029455537,-0.10733373,0.14535673,0.014114688,-0.034495756,0.014268608,-0.020981494,0.07626613,-0.08243238,-0.04877064,0.044596806,0.013081258,0.04934281,-0.056465346,-0.011394414,-0.013672003,-0.043749675,0.015877623,0.010101281,-0.057338018,-0.058713634,0.016383689,0.023539038,0.035754923,0.084310785,0.06509032,0.003872019,0.0061130845,-0.026809562,-0.053696405,-0.022553816,-0.055281103,0.025167784,-0.045528863,-0.055532407,-0.08970072,-0.052086584,-0.07005689,-0.03314449,0.033778723,0.05274594,-0.019420892,-0.015977977,0.006523734,0.03545979,0.016435664,0.093969405,0.0481753,-0.014985987,-0.01712118,0.047429852,0.034594815,-0.0025319473,0.025436308,0.065443456,0.023075951,0.014723859,-0.07513058,-0.003147286,0.049359266,0.05202093,0.11420047,0.011124219,-0.010947726,0.033137202,0.054995127,-0.01763094,-0.08493264,-0.0071086134,0.009030029,-0.054382805,0.013076269,0.050583564,0.02009501,0.02248687,-0.01297956,0.0019312535,0.014273088,-0.060745396,0.11001438,0.030359995,-0.03588335,0.017087832,0.036280647,0.0055176127,-0.035903905,0.020544136,0.033971768,-0.040445086,-0.0048700403,-0.08183979,1.804966e-33,0.04467501,0.07321005,0.016759202,-0.016791241,0.028135557,-0.0795054,-0.060467523,-0.04197669,-0.10265222,-0.03239489,-0.11007882,0.011298397,0.03201876,-0.024248848,-0.071642324,0.022753268,-0.076641075,0.031693343,0.07564794,-0.017433444,-0.04874283,0.0086639365,-0.02220028,-0.0035484491,-0.041416053,0.059623044,0.005763649,0.028397564,0.039698713,-0.00610569,0.0050122538,-0.091984436,-0.07325729,-0.020708388,0.035023093,-0.047253706,0.0030373873,0.0028360575,-0.06696998,0.039423857,-0.0020526098,0.08074821,0.01725333,-0.040961787,0.117773734,-0.03710451,-0.08827321,0.091233626,0.029351309,0.068992265,-0.048413534,-0.0125065725,0.062439978,0.025061807,-0.028601546,-0.015406824,0.019258125,0.052268177,0.08846126,0.044868134,-0.005365115,0.01471733,-0.00960769,0.019411579,0.037878115,0.039033294,-0.03626958,0.022218267,-0.0034863474,0.097870104,-0.049911298,-0.08526685,0.05726079,0.0045499173,0.002194518,-0.007657501,-0.062566474,-0.026791897,0.06289276,0.0043353774,-0.019085089,-0.012239654,0.023401253,-0.049565546,0.041306246,-0.07852168,-0.14078948,-0.014113075,0.0042738644,0.12615992,0.03288491,-0.012862338,-0.11684942,0.061323892,-0.010523738,-3.455244e-33,0.13211042,-0.13077095,-0.044851013,-0.1098068,-0.046475332,0.02396801,-0.0026971959,0.0075454633,0.017946703,0.050099324,0.120990954,-0.038303543,0.067339696,-0.005393471,-0.026154336,-0.09152375,0.053370774,0.1286782,-0.066399746,0.077183604,0.014123145,0.068314865,-0.01851498,0.03299805,-0.038289636,-0.0060551134,-0.0262832,0.0742541,0.015815778,0.072138466,0.03455935,-0.04049702,-0.05829743,-0.05624537,-0.02416619,0.03155215,-0.0042582834,-0.0007690626,0.07399286,0.08333271,-0.008522208,0.027577538,-0.023702962,0.05640622,0.1011463,-0.0011440478,-0.09181022,0.02386236,-0.0005304532,-0.08811131,0.00702186,-0.036560323,-0.022828238,-0.032155503,-0.008475873,0.02252209,0.011953568,-0.0076309573,0.0365888,0.028298104,-0.042476874,-0.06207108,0.05888732,-0.07985201,0.02067894,0.09351857,-0.024522202,0.063668035,0.070492476,-0.03215455,0.04654082,0.003086038,-0.0068904865,0.02730789,-0.05090721,-0.027751734,0.0025294875,-0.10459242,0.007541327,-0.005720789,0.03204161,-0.007397018,0.0043676808,-0.011261697,0.01993819,0.0069422713,0.05277729,0.09880408,-0.031867612,0.01262911,0.03908452,0.011617549,-0.08969162,0.13100848,0.031885885,-4.391498e-08,0.0029829943,-0.040273942,0.04954127,0.0049648364,0.0015791304,0.05006606,-0.017857928,-0.027649127,-0.0039409357,-0.09006024,0.006793254,0.05242325,0.0074666794,0.034978274,0.07119328,-0.0085575245,-0.012226856,0.042437434,-0.008653804,0.0077669076,-0.051292457,-0.018940127,0.015802145,0.013607969,-0.025384672,-0.07152837,0.04385626,-0.014786104,0.003095106,0.025546337,0.010368309,0.040970933,-0.031687178,0.05478422,-0.08309116,-0.073604785,-0.018480532,-0.039241053,-0.043761764,-0.031805705,-0.0027136083,0.016736042,-0.08713428,0.01796612,0.015389161,0.034409307,-0.026939305,0.048407253,-0.05514979,-0.043729663,0.054601762,-0.04682076,-0.018173924,-0.039580524,-0.059245206,0.023254976,-0.040965643,0.0043164,-0.033290077,-0.06990702,0.03948406,-0.025137747,0.15540832,-0.0382962 +1.14.20.12,"The enzyme has been characterized from an unidentified soil bacterium. It catalyses an Fe2+, 2-oxoglutarate-dependent monooxygenation at C-3, which is followed by decarboxylation and dehydration, resulting in the generation of a trans C-C double bond. cf. EC 1.14.20.11, 3-[(Z)-2-isocyanoethenyl]-1H-indole synthase.",384,1.0,-0.075519614,-0.027935935,-0.06801231,0.05849435,0.0070495806,-0.011264811,-0.05903435,-0.022296786,0.0039918856,0.016462825,0.00014979896,-0.11086585,-0.06240211,0.037216645,-0.104508735,0.022614138,-0.14270441,0.035527132,0.029253783,0.014512462,0.028478056,0.06621086,0.008544023,-0.038639303,0.032915168,-0.0048331954,0.027610617,-0.074249506,-0.07592739,-0.06539693,-0.0022575432,-0.04199065,0.07410596,0.0127840685,0.08911872,0.04083022,-0.04806966,-0.08392485,0.12622344,0.013802028,-0.085867226,-0.016958663,0.013014896,-0.02137447,-0.053165697,-0.021737395,0.041731898,-0.03010839,0.066356525,-0.031768113,0.04057768,-0.006776193,-0.07868927,0.029323336,0.0483024,-0.045878984,0.0039095916,0.037325084,-0.073015496,0.016757995,0.08408767,0.038216643,-0.01742067,0.0438384,0.026774025,-0.05207711,0.02229247,-0.046311412,0.017538369,-0.049589973,-0.08812524,-0.077263996,0.027605353,-0.06485278,-0.014630073,0.045225605,0.03545221,-0.0014233928,0.043530554,-0.06563947,0.028814351,0.010004684,0.025621189,0.07188066,-0.031125393,0.004714351,-0.0065526646,0.020069048,0.08806874,0.0071505485,0.009914605,0.032515805,-0.013496723,0.0009704818,-0.00952618,0.06011456,0.07298222,0.0753362,-0.014125858,0.008498256,-0.0062142634,0.09007568,0.02076532,-0.08896543,-0.0050698314,-0.00063145615,-0.0762217,0.04318779,0.050978556,0.06478742,0.020558149,0.022728905,0.019824844,0.014601233,-0.02603402,0.1023072,0.050735872,-0.03388594,-0.033863045,-0.02731716,0.018696599,-0.02316734,0.0001392601,0.022939084,-0.07767522,-0.0048177443,-0.092285946,2.693679e-35,0.06156133,0.052885268,0.008023542,-0.0005703181,0.012619376,-0.017572027,-0.061880503,0.014026926,-0.07434067,-0.013463644,-0.113713175,-0.08267742,0.08397055,0.012782437,-0.098101206,-0.046407577,-0.07395638,-0.012841067,0.036129754,0.0022085735,-0.011544091,0.06390625,-0.038527526,-0.0045816414,0.067138694,-0.04696405,0.033543836,-0.017136626,0.054620467,-0.03159,0.04887521,-0.059585758,-0.09708554,-0.039184976,0.05615475,-0.054144967,-0.0384969,-0.008544917,-0.04372805,0.06113665,0.045640588,0.020352546,0.052369226,-0.07051511,0.078380756,-0.01593822,-0.07672634,0.124775164,0.017551407,0.06861891,0.013911921,0.018929351,0.012230082,0.0073990854,-0.05276038,0.048591778,0.0075343256,-0.01954599,0.10644269,0.04681816,0.01950741,0.03191106,-0.023960251,0.03153286,-0.0036397625,-0.0035399962,-0.050220978,0.06650224,0.01199547,0.1314645,-0.065537706,-0.06591179,0.044760313,0.02723622,0.021381695,-0.030450871,-0.09416286,-0.021792507,0.099803865,-0.010240131,-0.045331404,0.010256623,0.03729399,-0.07156307,0.008683383,-0.042917736,-0.12685433,-0.010174483,-0.011401708,0.1433272,0.06547268,-0.016197478,-0.13430631,-0.005545337,-0.025558911,-2.476899e-33,0.082865626,-0.07623331,-0.087971225,-0.0870069,-0.044565815,-0.009486132,-0.024193497,-0.0275279,0.00612665,0.03579277,0.12763618,0.059386417,0.09556783,-0.0215528,0.047733318,-0.029802918,-0.009995265,0.065435186,-0.030748243,0.10655937,0.072243616,0.030094128,-0.052381057,-0.033428166,0.003911751,-0.010597537,-0.04977692,0.09351123,0.048737332,0.046730123,0.018305734,-0.054210074,-0.021890886,-0.048965845,0.002969403,0.052959323,0.004993118,-0.0941704,0.04351527,0.06147405,-0.038574956,0.014720557,-0.048999254,0.07905405,0.07602772,0.022194048,-0.07797973,0.021730432,0.035089713,-0.043254998,-0.009201797,-0.0058549284,-0.024099926,-0.0377153,0.032986943,0.02233369,-0.006330445,0.002709175,-0.011524536,0.013778593,-0.013610229,-0.03348756,0.0650337,-0.04576948,0.024076257,0.063682266,-0.02150923,0.08450331,0.021795614,-0.02235274,0.081144065,-0.0023866897,0.023016155,-0.01056093,-0.035817936,-0.105038285,0.01414167,-0.014967118,-0.000112934606,-0.03205455,0.035449147,0.014225615,0.07228635,-0.010442163,0.025117418,-0.06247216,0.053668868,0.041309465,-0.019791761,0.028175214,-0.018996391,0.03461951,-0.06716306,0.094052136,0.08393677,-4.301062e-08,-0.053312212,-0.03246593,0.052437473,-0.022758283,0.042633735,0.027040703,0.007310731,-0.017881071,-0.016757466,-0.0991137,-0.014167025,0.081935115,-0.025237342,0.03612024,0.02483014,-0.016311005,-0.07779693,0.022223221,-0.0472539,-0.004665496,-0.048221663,-0.00962448,-0.07607203,0.032276254,-0.0012611871,-0.031229943,-0.0066505345,-0.017787922,-0.029739402,-0.029508509,-0.02410213,0.07381694,-0.01984726,-0.024978418,-0.06658111,-0.043621145,0.012196188,-0.052879762,-0.017035544,0.025171222,0.014663194,-0.0010721599,-0.03766238,0.01886925,0.04333735,0.024339793,-0.06787362,0.029725986,-0.039171435,-0.040243283,0.10985275,0.012410207,0.003993432,-0.022698365,-0.027108384,0.03027377,-0.07246263,0.00884337,0.01595,0.033805415,-0.04508554,-0.014387623,0.15213159,-0.052389212 +1.14.20.13,Requires Fe2+ and ascorbate.,384,1.0,0.004124434,-0.051354267,-0.060412705,0.09901642,-0.011559343,-0.019695476,0.009181307,0.013098153,-0.049380504,-0.037341837,0.03959026,-0.0055141808,-0.08832038,0.059819613,0.042381227,-0.039317414,0.098113924,-0.0325441,0.015588932,0.051180568,0.123099945,-0.028480688,0.08289687,-0.05802108,-0.07791917,-0.014590836,-0.04010224,-0.024484629,0.034198742,-0.08973618,9.3954106e-05,0.0048319628,-0.007135337,-0.06491593,-0.07164672,0.0041014636,-0.020468865,-0.0048646093,-0.03402048,-0.014489571,0.023970854,-0.074299574,-0.02160852,0.023310533,0.016668228,-0.039474797,0.090037085,-0.04664531,0.060221747,0.05835281,-0.05206555,-0.02244425,0.024491256,0.071849935,-0.030625233,-0.021087443,-0.040811565,-0.054319482,-0.016097303,0.023016851,-0.07018526,0.009026886,-0.039565776,0.028430779,0.014954204,0.0010352334,0.010944532,-0.032164503,-0.018683458,0.048419975,-0.042469017,0.0014899017,-0.020810528,0.05150577,-0.0026296722,-0.00884715,0.0505166,-0.056830365,0.067691326,0.022053778,-0.10321405,-0.0538491,0.004538305,0.05587948,0.046709508,0.08306765,-0.024001647,-0.0384922,-0.1337014,0.088401444,-0.02572032,0.040524453,-0.022029905,0.019421227,-0.010993662,-0.02727087,0.018769413,-0.015915742,-0.077441275,0.04130723,-0.08133127,0.0718422,-0.054680616,0.056784797,-0.009606944,-0.06435656,-0.07635962,0.00744762,0.003978297,-0.011408741,0.015102946,-0.0057537006,0.018099647,-0.0061748745,0.03272898,0.069261916,0.0058845216,-0.0025713267,0.014989733,-0.004228114,0.05205622,-0.0026679407,-0.055393063,0.038267307,-0.04996847,-0.09770224,0.032118384,-7.1639475e-34,0.05841243,0.10381546,0.044895284,0.0624173,-0.058408987,0.084315814,-0.0484664,-0.03332188,0.02412716,-0.02661737,0.0033307474,-0.062410492,0.017200667,0.033913728,0.048683126,-0.14971116,0.021229649,-0.026431022,0.080655135,-0.04873955,0.059519533,0.035531264,-0.0020676528,-0.0074908165,-0.05770358,0.08081117,-0.028241668,0.009227095,0.018702412,0.039029438,0.020965923,-0.019656487,-0.037403725,-0.055228565,0.027502047,0.039120946,-0.044212554,-0.047428537,-0.021039028,-0.010531438,-0.024407499,0.03544007,-0.09694866,-0.024670115,-0.018324574,-0.07179034,0.036607143,0.06970383,0.030849837,0.07003276,-0.0053930925,0.052110903,0.07791187,0.005462096,-0.012642633,0.02275819,-0.010304155,-0.048324008,0.02519482,0.063924804,0.0626058,0.009885993,0.012501716,0.0510577,-0.068664655,0.04343895,-0.012236792,0.016121069,-0.012297096,-0.0021210157,-0.06938487,0.07362139,0.06461386,-0.006003747,-0.011510255,-0.0029026987,-0.05858666,-0.07215756,0.058810737,-0.017007004,0.0034846575,-0.06354861,-0.0253717,0.021897424,0.022731839,-0.017746337,-0.021823423,0.008806094,0.05394825,-0.047474727,0.0137573425,-0.043390773,0.029154362,-0.082994014,0.054455735,-2.4161155e-34,-0.014195737,-0.0718742,-0.010806257,0.06985909,0.03920389,0.05977598,0.040455677,-0.112389594,-0.06295592,0.04418154,-0.0004156027,0.02244394,0.016045269,-0.038251106,0.050148003,0.013290346,-0.0661799,0.04687132,0.0648844,0.027702792,-0.0029073327,0.1237578,0.04144074,0.09312009,0.0028234294,0.039927486,-0.046164937,0.0011801299,0.008131356,0.06171399,0.062941216,0.015005858,-0.103732534,-0.08662015,-0.06788121,-0.028836424,-0.001562136,0.050091196,-0.015815953,-0.039836664,0.013529718,0.023907416,-0.01549037,0.1605826,-0.030886173,0.00841369,-0.014370387,0.026236176,0.06257649,0.10479247,-0.03628514,-0.081199065,-0.110691965,-0.07589982,-0.003115336,-0.0648983,0.07300865,-0.03513872,-0.009218595,0.042570006,0.0074040033,-0.024664266,0.0062943897,-0.057389293,0.08022398,-0.04534081,0.031465877,0.13557026,0.06832914,0.078610055,0.02525788,0.10850726,0.10252656,-0.09303516,0.025837854,-0.00808202,-0.0175572,0.007170376,-0.008954623,-0.037027992,-0.045662183,-0.02351984,0.024727657,-0.016372884,-0.0142566655,-0.09442157,0.04630112,-0.034304302,-0.07306289,0.019616093,-0.0750716,0.0024076207,0.078918405,0.05467998,-0.0027565039,-1.8126642e-08,-0.08050925,0.010130529,0.049432673,-0.020129232,0.0071261222,0.025264323,0.036105826,-0.05996495,0.0040671197,-0.052028347,0.0017699895,0.0790233,0.16072726,0.04275628,0.053195626,-0.044865057,0.05511907,0.11720408,-0.062657915,-0.06661379,-0.09723387,-0.06789632,-0.051061172,0.026112782,0.026207205,0.021803517,0.035006654,0.006111371,0.084354594,-0.029238822,0.026229862,-0.043917373,-0.003059834,-0.028853405,-0.10537471,-0.030031051,-0.023757808,0.00016009774,-0.03562493,-0.03339227,-0.011417447,-0.006316148,-0.013844411,0.038314328,-0.045274302,0.0023489755,-0.004488566,-0.06112775,-0.048164006,0.07229555,0.021424996,0.0033747712,0.025545679,0.0072756642,0.014615922,0.075033605,0.008413371,0.009344983,0.09265562,-0.03857441,0.07211084,-0.02583843,0.07285315,-0.04682338 +1.14.99.60,"This prokaryotic enzyme catalyses the last hydroxylation reaction during the biosynthesis of ubiquinone. The eukaryotic enzyme is classified under EC 1.14.13.253, 3-demethoxyubiquinone 3-hydroxylase (NADH).",384,0.99999994,-0.07404093,0.036768958,-0.08238273,-0.031132242,0.016567815,0.016289473,-0.060425796,-0.021700606,-0.014295874,-0.053702854,0.0001829794,-0.038922023,-0.017847108,-0.006108746,-0.025772493,0.069318965,-0.100923076,-0.04374724,0.0017325609,-0.06300176,0.038308673,0.043286197,0.014626002,0.020885173,0.07742547,-0.016167814,0.07550024,0.0067479955,-0.03113854,-0.054002736,0.021986032,-0.06253541,0.012683058,-0.08270841,0.0014888913,0.084381856,-0.07800995,-0.07343437,0.015168553,0.037081998,0.043694336,-0.08168082,-0.035281237,0.059141483,0.015833756,0.050965227,-0.026062863,0.064333074,0.09928168,0.058894258,-0.042771783,0.0013818616,-0.019861365,0.06402758,0.06448264,-0.045051727,0.014099254,0.035553377,-0.016896643,-0.01675147,-0.014958447,0.0037491221,-0.0075345435,0.024113795,0.024214994,-0.02160113,-0.024744665,-0.06389229,-0.011548692,-0.008632404,-0.040891077,-0.09257655,-0.05365085,0.008324312,-0.0982189,0.027525717,-0.06267658,-0.037402466,0.0126116965,-0.0009575634,0.036737442,-0.017911443,0.02041047,0.07072367,0.015864344,-0.0051324787,0.00175226,-0.027156997,0.039778966,0.03758683,0.0042168517,-0.036960974,-0.06191003,0.05988463,-0.08971243,0.04506448,0.09098474,0.07311193,0.01977566,-0.01262553,-0.008364881,0.046149053,-0.042712018,-0.11518221,-0.047054764,0.06277264,0.015194843,0.1158944,0.018965792,0.014742416,-0.04051573,-0.071270436,-0.025974657,-0.0314009,-0.036424823,0.07044142,0.04191018,-0.023486836,-0.079224125,-0.063759506,-0.008841116,0.061320424,0.045596387,0.023116672,-0.017496744,-0.0052500716,-0.09638821,1.2987307e-33,0.08790238,-0.0014173895,-0.045610122,-0.026042439,-0.03406333,0.057000823,-0.078731135,0.041981462,-0.09274257,-0.07549985,0.0010387738,-0.027898034,0.022680974,0.008677075,-0.042844687,-0.040178996,0.022832762,-0.058587026,0.010023782,0.03444766,-0.030799262,-0.013418818,-0.06238841,-0.04660413,-0.057682294,0.05599224,-0.009571542,0.03911777,-0.016577221,0.021073785,-0.039311573,-0.10225005,-0.09858274,0.0012502174,-0.008007204,-0.0025723884,-0.072128974,-0.041945066,0.015551629,0.034669902,-0.028034903,0.061237942,-0.00720191,-0.092013255,0.068845235,-0.022050483,0.012808452,0.1525686,0.035284467,0.021273855,0.037062895,0.014627626,0.12553662,-0.049922604,-0.05851099,0.032662347,0.010133275,0.03580621,0.012379452,0.04835916,-0.017482542,0.034817867,-0.011864409,0.055233113,-0.04034763,0.0032256893,-0.054646697,0.01113917,-0.010746571,0.048314724,-0.013629755,0.0068743066,0.06986818,0.0060512535,0.024949659,-0.021946557,-0.007024111,-0.037790302,0.05107259,0.0022594065,-0.047016025,0.0055145053,-0.026326444,0.008187065,0.03222242,0.09161243,0.022803701,-0.005079344,-0.08001319,0.09899219,0.03645383,-0.04969753,0.016102044,0.010739864,0.052578617,-3.086688e-33,0.09001854,-0.04791239,0.022190183,-0.1277342,0.015930738,0.044789795,0.04966369,0.01592107,0.028659893,0.04212125,0.104388356,0.0067187026,0.031546824,-0.030768085,0.040363804,-0.011527505,-0.01895403,0.09029726,0.02714624,-0.025417972,0.10711204,0.09537314,-0.05722002,-0.017755855,-0.0072177965,-0.039891396,-0.020230347,0.048540227,0.062609546,0.065506905,-0.048084658,-0.040330727,-0.063949235,0.032596666,0.018166015,0.09631785,-0.039990142,0.042805858,0.07144155,0.028764645,0.014103367,-0.00347451,-0.087278344,0.03247599,0.084895544,0.09912143,-0.12682231,0.0936155,-0.023066385,-0.03327322,0.032069635,0.024004504,-0.0119876405,0.012469722,-0.015128914,0.05088617,0.012968508,-0.009520101,0.04177089,-0.052980803,-0.024995264,-0.025679989,0.057564776,0.038160086,-0.040481225,0.065457694,-0.032901537,0.02560053,0.0047756834,0.004633917,0.099616945,0.012743694,-0.06536968,0.049445193,0.017008835,-0.018729521,-0.062922806,-0.046573274,-0.027021073,0.028058697,0.06482908,-0.0060358695,0.027811216,-0.014405807,-0.056810986,-0.0570261,0.02072809,0.038081124,-0.053447295,0.06600458,-0.026337842,0.023201076,-0.08843033,0.044526123,0.049729917,-2.9225166e-08,-0.008544361,-0.062448367,0.07907691,-0.051554658,0.058529876,0.059070814,-0.007259736,0.04728808,0.07425167,-0.04187615,0.04996805,0.04844384,0.03609875,0.009663989,0.03182104,-0.029796379,0.08828013,-0.008600966,-0.0010439804,-0.008969952,-0.045358747,0.018101161,-0.054391317,0.0075713014,-0.039028183,-0.055284988,0.04907732,-0.01082334,-0.043777294,-0.09550521,-0.00027380273,0.04101864,-0.042131186,-0.06792184,-0.101662815,0.03809259,-0.054358203,-0.03111833,0.042208433,-0.0095646065,-0.057297673,-0.07399221,-0.027718773,0.032881614,0.02589699,0.0027189385,0.04330332,-0.014308851,-0.05074908,-0.025590276,0.06980209,-0.06946167,0.056260627,-0.10219887,-0.045682628,0.027030261,-0.075585626,-0.077661194,-0.036569003,-0.12895894,0.036266387,0.051957775,0.18775223,-0.0613066 +1.18.6.2,"Requires Mg2+. This enzyme, originally isolated from the bacterium Azotobacter vinelandii, is a complex of two components (namely dinitrogen reductase and dinitrogenase). Dinitrogen reductase is a [4Fe-4S] protein, which, in the presence of ATP, transfers an electron from ferredoxin to the dinitrogenase component. Dinitrogenase is a vanadium-iron protein that reduces dinitrogen to two molecules of ammonia in three successive two-electron reductions via diazine and hydrazine. Compared with molybdenum-dependent nitrogenase (EC 1.18.6.1), this enzyme produces more dihydrogen and consumes more ATP per dinitrogen molecule being reduced. Unlike EC 1.18.6.1, this enzyme can also use CO as substrate, producing ethene, ethane and propane [7,9].",384,1.0,-0.059871912,-0.01363631,-0.10781984,-0.0047465134,0.08144133,0.001710458,-0.015142436,-0.002023704,0.0003573882,-0.06780198,-0.07989806,-0.03881421,0.0007687112,-0.0025036577,-0.046335272,-0.06966398,0.027200645,0.012349299,0.011734007,-0.047476657,0.03376142,0.009679737,0.0022149833,-0.06367509,0.037758153,-0.024141999,0.013507964,-0.0015721059,-0.05977115,-0.07713721,0.010784937,0.012621724,0.040370535,-0.10844003,0.028922196,0.062759236,-0.048592933,-0.0223148,0.014486682,0.021769071,0.03809053,0.010902314,0.036474846,-0.056462675,-0.03897953,-0.0030320988,0.038972773,0.0749231,0.053966813,-0.029054347,-0.06642426,-0.028323518,0.007540862,0.033693384,0.05171593,-0.010589866,-0.045035776,0.011990757,-0.07341854,0.03624528,0.078189105,0.006435141,-0.017205345,-0.031420335,0.092276864,-0.02440974,-0.00075714214,-0.10446861,0.030216813,-0.04654665,-0.0621173,-0.029476764,-0.018358523,0.02982832,-0.036072794,0.025667096,0.029156793,-0.017794307,0.0820426,-0.034120005,-0.07362226,0.080589026,0.06428771,-0.021030195,0.023282439,-0.054094367,-0.0046458896,0.008848667,-0.01251669,0.057772204,-0.00610099,0.036254246,0.070729464,-0.034792352,-0.036421284,0.041544776,-0.019171849,0.042903587,0.008316844,0.0013243482,0.021261621,0.10699153,-0.10766829,-0.085936815,-0.11135936,0.024175968,0.04082315,0.11465378,-0.0035150629,0.049605057,0.019071192,0.070812285,0.036216553,-0.007329579,-0.023224158,0.041043933,0.04265881,-0.037132263,-0.080104716,0.07969399,-0.00859786,-0.053634055,0.056542847,0.06517167,-0.0011218081,0.04098951,-0.11956464,4.673593e-33,0.031127797,0.041817624,-0.0013267468,-0.025807776,0.008334656,0.04123838,-0.09358747,0.011838646,-0.02049589,-0.0758478,-0.025720965,-0.037886683,0.04902946,-0.05103143,-0.022333404,-0.049730442,-0.028654087,0.0404485,0.071644485,0.06623863,0.06931593,0.080742024,-0.029723424,0.07227209,0.05256255,0.07525737,0.004823666,-0.017050207,-0.020328585,-0.0035375445,0.019909749,-0.13469633,-0.07756541,0.016185401,0.065053664,-0.12214359,-0.06390727,0.0032841126,-0.030370101,0.0049837064,-0.054120176,0.050193153,-0.03525081,-0.005820947,0.031944174,-0.016405417,-0.06617716,0.0731283,0.046784393,0.033990473,0.023658384,-0.020838114,0.08271432,-0.022790145,-0.076029114,0.027797852,-0.0132402545,0.025577381,0.04841634,0.00681331,-0.0021017592,0.08944881,0.034156047,0.030794522,-0.028897697,0.050463792,-0.052682344,-0.07252158,0.071259916,0.09623678,-0.0751457,0.025082039,0.06899882,0.023305599,0.06021352,-0.06483576,0.0063811056,-0.07728059,0.048660357,0.003925557,-0.020258736,0.0057939836,0.015870614,-0.07510347,-0.048977923,-0.083413355,-0.07332102,0.009710822,0.056689583,0.00973216,0.091749005,-0.05031582,-0.06593769,-0.027044265,0.02688453,-4.1712175e-33,0.10738862,-0.0434273,0.04254038,-0.07065421,-0.07058487,0.011236175,0.034729462,-0.07433232,0.021934342,-0.039957516,0.103177845,-0.012459497,0.041426074,-0.024813127,-0.014266442,-0.0012551789,0.028928198,0.0029315385,0.020882659,-0.0035771404,-0.04800459,0.082279034,0.015377654,-0.05312314,0.010355957,0.028978663,-0.034822233,0.06616136,0.09093683,0.025470685,0.014587675,0.06685633,-0.049030345,-0.083006345,-0.038857345,0.029368348,-0.06524451,-0.017350236,-0.03763086,0.0025043979,0.055768237,0.02755729,0.024143483,0.07762434,0.033475596,0.01575043,-0.08394563,0.015670687,-0.0021242236,-0.008573079,0.08756273,-0.0453851,-0.0487191,-0.011502547,0.016135639,-0.014185151,0.086834826,0.03706287,0.0021334332,0.056255575,0.017316937,-0.08538994,0.05333746,0.035692386,-0.019127596,0.0318461,-0.010286901,0.11660956,0.033467777,0.071294904,0.048485007,-0.025387818,0.13644415,0.07047274,-0.015360992,0.04237471,0.02750109,0.02754767,-0.006885692,-0.024968816,-0.09767791,0.020184396,-0.07441578,-0.08734684,0.022320308,-0.028351532,-0.015331119,0.0578613,-0.02061859,0.049698897,-0.045256406,-0.05594655,0.01748391,0.020976521,0.0052800025,-4.7500954e-08,0.047709703,-0.099548504,0.05173936,-0.02806771,0.016483946,-0.004737824,-0.01203637,-0.022021094,0.07693339,-0.064551346,0.05074347,0.05266939,0.041610386,-0.05361022,0.10160019,0.036353122,-0.0104608685,-0.018865278,-0.041554358,-0.03014173,-0.018858802,-0.05159474,-0.1968614,0.06334103,0.0063885935,-0.0557544,0.014324395,0.013341144,0.006380298,-0.08327064,-0.014261014,0.058583744,0.059592426,-0.026168024,-0.0698019,0.016093837,-0.035468988,0.03184134,-0.026709747,-0.013876626,-0.035817146,-0.013860944,-0.03802458,-0.0021529004,-0.033744898,0.025534937,0.019012736,0.00953224,-0.017668685,-0.013154917,-0.019371873,-0.0038190552,0.04030212,-0.024555141,-0.07373633,0.10516688,0.004270936,-0.08036467,0.014486919,-0.019787231,-0.042961165,-0.05421395,0.11887324,-0.05496681 +2.3.1.269,"This bacterial enzyme transfers a fatty acid from a membrane phospholipid to form an amide linkage with the N-terminal cysteine residue of apolipoproteins, generating a triacylated molecule.",384,1.0,-0.09811785,-0.06591697,-0.097142905,0.009565476,-0.009471804,0.04130686,0.0012050912,0.051705908,0.02935291,-0.039464876,0.085837595,-0.1069328,0.009595313,0.043193687,-0.011155731,0.036399897,-0.075018704,0.0048758704,0.0080777975,-0.051617492,0.0329016,0.0685959,-0.04764764,-0.02543504,-0.0255433,-0.00051884697,0.11651221,-0.02345664,-0.024010573,-0.035615485,0.004408477,-0.015768515,0.058182098,-0.06446532,0.06972852,0.094709255,-0.0022788197,-0.01196288,0.067058705,-0.0009091667,0.021158172,-0.027720105,0.06408809,0.020568779,0.029423198,0.016846688,0.016311176,0.11589906,0.07172653,-0.06451779,-0.061508168,-0.049383737,-0.051382326,0.024136914,0.018044326,0.060836863,-0.04972184,-0.02156555,-0.04789921,0.0024914818,0.0013437421,-0.034022238,0.040481668,0.015539031,0.0027328858,-0.08376088,0.031233624,-0.091834344,0.01017097,-0.015011756,-0.07981443,-0.056886394,-0.01457515,-0.027382363,0.0016871829,0.020140937,-0.064309776,-0.019356387,0.02970645,-0.05576431,0.07568573,-0.04588118,0.0029329914,0.077875674,0.033259608,-0.060196824,0.034370918,0.022225924,0.029917954,0.04984349,0.0074702227,-0.04587057,0.03476774,-0.028415084,-0.16539145,-0.009769679,-0.010416366,-0.012457661,0.0055279136,-0.026223682,-0.025537664,0.0579529,0.0024796017,-0.06159094,-0.046799637,-0.017540606,0.036314227,0.081233725,0.039992657,0.029280582,-0.009149302,-0.008318719,0.053834435,-0.026982525,-0.0017378755,0.03239343,0.016077368,-0.065415785,-0.06776498,0.036048405,-0.026732294,-0.0475167,-0.030999342,0.04515932,-0.06804878,0.015738321,-0.08571048,2.4074978e-33,0.053003456,0.044862337,-0.02146771,0.012928022,-0.018898802,-0.061537307,-0.08229745,-0.056480672,-0.0073369187,-0.104591005,-0.051662058,-0.065770686,0.009975229,0.04510881,-0.033302426,-0.05018336,-0.008679175,0.08874619,0.0704659,0.013977903,-0.029695937,0.08126032,0.03341513,-0.043536857,0.102611236,0.055160746,0.0037922575,-0.010997224,0.09135324,0.000975236,-0.03869979,-0.07859505,-0.07378936,-0.010080681,0.09844074,-0.01397403,-0.005907537,-0.045865983,-0.035867818,0.060138185,-0.04424448,0.00253394,-0.0039035624,-0.012027605,0.024931736,-0.011076725,-0.076306455,0.09389969,-0.007268519,0.018974235,0.03922237,-0.048724815,0.10205927,0.05000265,-0.08185865,0.0006350454,-0.029222718,0.0076199905,-0.02278427,-0.044262607,0.018521646,0.07111748,-0.09963595,-0.006597628,-0.019543331,0.0100267455,-0.0512754,-0.07693788,0.019286467,0.14288743,0.0140770385,0.024787843,0.03845058,0.105869755,-0.016389009,-0.013440408,-0.061238393,-0.0027703086,0.06372134,0.008428207,-0.013679844,-0.017613431,0.044697683,-0.031036314,0.009260246,0.02352765,0.01472984,-0.00043248417,-0.045585237,-0.052345987,0.033001553,-0.04801652,-0.014664278,0.062806755,-0.030549724,-3.2673483e-33,0.09874866,-0.08386835,0.019405976,-0.0896317,-0.041347448,0.06320938,-0.027211972,-0.043228716,0.062269647,-0.022069914,-0.0073231948,-0.016008789,0.06351562,0.013762578,0.028601052,0.018896574,0.020388277,0.056678634,-0.035956096,-0.06436101,0.0344182,-0.03857444,0.022602197,0.08714159,-0.0242754,0.045909718,-0.045327317,0.07429306,-0.007679743,0.09515581,-0.020113477,-0.07341052,0.0012118296,-0.11628568,-0.013537598,0.120523974,-8.952764e-06,0.0151302535,-0.0055807875,-0.016994396,0.00981296,0.0034988828,0.030571979,0.03346976,0.023882944,0.03462422,-0.031414445,0.08772429,-0.06525603,-0.08494794,0.011420145,0.007269392,0.021333525,0.004563325,-0.02755884,0.076069854,0.00033508995,0.04259999,0.038354874,-0.110895656,-0.09035639,-0.13534814,-0.009182591,-0.01837895,0.03775539,0.062384482,0.017090876,-0.06830349,-0.012922742,-0.0072597843,0.035458982,0.06923847,-0.003222419,0.072547585,0.011626371,-0.015070481,-0.05505715,-0.08634952,0.053900253,-0.010902037,0.0099483635,-0.03571231,0.041145932,-0.044211343,0.008363212,-0.07947748,0.08943675,0.028251752,-0.00706448,0.008985628,0.014611426,0.021824367,-0.03189825,0.041311823,0.05060596,-3.1478447e-08,0.08163055,-0.054498356,-0.018355645,-0.06700383,0.041633878,0.059300702,0.0035648718,-0.014594052,0.060371935,-0.09353984,-0.037787255,0.07754604,-0.013750166,0.072138585,0.0476057,0.07467656,0.012734605,0.015957404,-0.033314772,-0.07745479,-0.031378377,0.0026370697,-0.06377182,0.027951619,0.012969133,-0.016829347,0.035659272,-0.007808743,-0.0598112,-0.0017985693,0.012386995,0.023060197,-0.054472562,-0.012952323,-0.022775747,0.05955834,0.0027107752,-0.03977306,-0.0066533773,0.10182936,0.054589946,0.048962727,-0.10222023,-0.011897343,0.061591994,0.027821904,-0.02842369,0.033420056,-0.05000028,0.01735562,0.06499038,-0.017180398,0.022224877,-0.042615756,-0.12164282,-0.07173547,-0.01572559,-0.03573001,0.013593419,-0.007924234,0.016266586,0.073618315,0.18960002,0.015033073 +2.3.1.270,This bacterial enzyme catalyses the second step in the formation of ornithine 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+2.3.1.271,"The enzyme, characterized from the yeast Saccharomyces cerevisiae Sigma1278b, N-acetylates L-glutamate 5-semialdehyde, an L-proline biosynthesis/utilization intermediate, into N-acetyl-L-glutamate 5-semialdehyde, an intermediate of L-arginine biosynthesis, under oxidative stress conditions. Its activity results in conversion of L-proline to L-arginine, and reduction in the concentration of L-glutamate 5-semialdehyde and its equilibrium partner, (S)-1-pyrroline-5-carboxylate, which has been linked to production of reactive oxygen species stress. The enzyme also acts on (S)-1-acetylazetidine-2-carboxylate, a toxic L-proline analog produced by some plants, resulting in its detoxification and conferring resistance on the yeast.",384,1.0,-0.048470035,-0.12135213,-0.06314225,-0.0050705355,0.1319885,0.0908575,-0.036961313,0.055088572,-0.00919757,0.035068627,-0.018126972,0.03461159,-0.0380591,-0.05249364,-0.07644458,0.042788032,-0.09969169,-0.06583565,-0.041606955,-0.034873914,0.056415047,0.04547618,-0.034550767,-0.017777577,0.08676744,-0.07361244,0.040953215,0.0032933832,-0.03325178,-0.08935377,0.024670603,-0.06019453,0.020436287,-0.040790457,0.046255358,0.013425087,-0.033198107,-0.042671744,0.055735946,-0.029248143,-0.07557511,-0.00078962225,-0.0967587,-0.012280936,-0.023663765,0.012894208,0.017902603,-0.05057232,0.0043844352,-0.022900261,-0.007859668,0.01641306,-0.025690487,-0.05777691,-0.053112034,-0.017222261,-0.034127787,-0.03546496,-0.0064211255,0.032607276,-0.01875658,-0.019810496,0.023802511,-0.044563424,-0.03973685,-0.043423437,0.048298325,0.017832175,0.036245305,-0.014043445,-0.093369804,-0.07141891,0.010631433,0.044640943,0.0061424095,0.014681,0.04072716,-0.09815837,0.038255796,0.01178884,0.05964753,0.021837646,0.025457028,0.05652817,0.043901663,-0.0836702,-0.016765404,0.0976904,0.11150724,-0.010015914,0.053057257,0.008929183,0.02627876,0.062489547,-0.03584188,0.011889967,-0.007772583,0.012694916,-0.049224935,-0.043288045,0.014685883,0.07146126,0.018102212,-0.09727261,0.044074655,0.041117914,0.0521147,0.047730777,0.017234622,-0.007816364,0.058216434,-0.004563442,-0.018787509,-0.028425366,-0.050928928,0.027542137,-0.0057480466,-0.066901,-0.042949036,-0.020295974,0.028745309,0.041888934,0.015211897,0.0076390035,-0.042942993,0.0073715793,-0.014210412,3.6678025e-33,0.023423303,0.03144765,-0.05998055,0.04698292,0.07402502,-0.024695437,-0.108328946,0.0077119316,0.046263114,-0.0051999036,-0.04477062,-0.069997154,0.012079296,-0.018965492,-0.027444152,0.041482423,-0.049932398,-0.044181388,0.041326344,0.01419292,-0.06807758,-0.0015863047,-0.07109873,0.0766171,0.022255218,0.027420761,0.057541497,0.052544355,-0.009029188,-0.008719392,-0.015766742,-0.14713113,-0.02430624,0.009396625,0.058120675,-0.0005167611,0.026939532,-0.005242268,0.025957694,0.057060644,-0.021343047,0.10412436,0.0019598417,0.033429954,0.055826038,-0.04781546,-0.080345586,0.13410634,-0.02627945,0.093444295,0.011994171,-0.043801907,0.12022684,0.03456125,-0.015033219,0.08144327,-0.08239317,-0.018256368,0.09687801,0.051513907,-0.0307393,0.022940146,0.003960766,0.035321485,0.026198264,0.061911955,-0.037243467,-0.07949802,0.0033181112,0.034642413,-0.055600863,-0.048707582,0.07630129,0.012900344,-0.005886937,-0.022913901,-0.06460813,0.05196532,-0.001026806,0.04342459,0.0058351783,0.008125982,-0.046001688,0.013686105,-0.039685693,-0.05247138,-0.022002839,-0.02279136,0.005080793,-0.0140161365,0.071457386,-0.074899666,0.05269385,0.04525707,-0.013802379,-3.2001504e-33,0.10890911,-0.066332385,0.06074299,-0.061706677,-0.0065297983,0.09398317,0.028569104,-0.056439035,-0.018860398,0.004941199,0.046469506,-0.0013899292,0.011448115,0.019746128,0.06116951,-0.036493693,-0.00061265775,0.12757292,-0.0160657,-0.0045853597,0.06841189,0.0862568,0.01501113,0.089311816,0.0869138,0.0038136432,-0.01904753,-0.015420277,0.049108993,0.04098524,0.05308986,-0.01641245,-0.017189361,-0.073108084,-0.0069731693,0.064118996,0.0019078633,0.038813185,-0.084224574,0.07956494,0.017831549,0.086101,-0.032959204,-0.0015845589,-0.024559781,0.04532892,-0.059084907,-0.05955738,0.033009343,-0.10218772,0.044055436,-0.030114407,-0.06289544,-0.040068243,0.062045872,-0.008321482,-0.0010376199,0.014267936,-0.028901601,0.013594696,-0.00515015,-0.07583627,0.00055796845,-0.05403105,-0.00424042,0.024300862,0.012105314,-0.011927191,0.062187575,-0.0115717305,0.05052599,0.041389827,0.052175954,0.06154334,-0.07737393,0.011952701,-0.026327139,-0.08235528,0.0142831225,-0.029396672,0.019233363,-0.052617013,0.032645382,-0.011867017,-0.10762127,-0.07457502,-0.033792123,0.14945059,0.06127289,0.049031854,-0.029029729,-0.037943926,-0.059606794,0.07994924,0.06419548,-4.798018e-08,0.034052882,0.009519478,0.064564735,-0.05446812,-0.025044592,0.05239378,0.06611131,-0.028026646,0.08041724,-0.0137935355,-0.020348081,0.14238048,-0.021864256,0.03906175,-0.021004047,0.0122511005,0.0012889059,0.05360659,-0.008480381,0.08380895,-0.028939873,0.012505549,-0.08071811,0.0050651967,0.0271521,-0.09397107,0.07239003,0.04972941,0.026065478,-0.052974932,-0.04317463,0.060396228,0.001874014,-0.07952288,-0.10746296,-0.012252109,0.011435821,-0.008414179,-0.063564464,0.060151767,-0.066972055,-2.5963202e-05,-0.058527622,-0.013836537,-0.030470831,-0.006008882,0.02067159,0.009630857,-0.03575032,-0.03588356,0.032498766,-0.03067584,-0.0364889,-0.02434584,-0.1048546,0.01940427,-0.065237425,0.0033581664,0.052214283,-0.08640477,-0.0033492183,0.017284373,0.1273791,-0.06339612 +2.3.1.272,"The enzyme from the bacterium Pseudomonas sp. YGJ3 is composed of three subunits named PhlA, PhlB and PhlC. Production of 2,4-diacetylphloroglucinol, which has antibiotic activity, is strongly inhibited by chloride ions.",384,1.0,-0.057595335,-0.06329463,-0.10719808,-0.0076284255,-0.020098882,0.0169672,-0.023603471,0.0010622997,0.036416933,-0.040971983,0.021574426,-0.085868284,-0.0666736,0.10306794,0.02601385,-0.019462002,-0.08304998,0.06894082,-0.032203525,-0.0549187,0.09280403,0.061207842,0.035886962,0.08286955,0.024998426,0.037745796,0.08332998,0.0009182314,-0.017348895,-0.06320443,-0.076065764,-0.038105864,0.13316175,-0.06667442,0.09052679,0.025580099,-0.044753548,-0.017729415,0.09609759,0.0063892854,-0.011155664,0.024008399,0.047393564,0.0015825625,-0.02756939,0.028082673,-0.060683187,0.030751217,0.07065441,-0.022237502,-0.06263813,-0.030079842,-0.013791965,0.08785068,-0.0025433335,0.037810653,-0.017786033,-0.007872431,-0.013281234,0.042285737,0.012578613,0.05358627,-0.037580147,0.029593388,-0.022150261,-0.021848734,0.019798633,-0.105771855,0.027626645,-0.029997608,-0.05470385,-0.07876759,0.04603354,0.02637909,0.0056116846,-0.019870955,0.058213107,-0.01149047,-0.01743924,-0.024649583,0.051511917,-0.022456923,0.0014856812,0.123923115,-0.04269787,-0.054251447,-0.032756187,-0.012322222,0.058801197,-0.0039232145,0.030265719,0.016779294,-0.03778143,-0.060478803,-0.05616305,0.097638875,-0.045699656,0.014419686,0.061375953,-0.01391387,0.05109342,0.022624006,0.11033935,-0.06672275,-0.03288198,0.018916855,-0.0049004727,0.08063913,-0.04438257,0.0316516,0.01413052,0.008242754,-0.009517675,-0.05743041,-0.03860105,0.019549299,0.089034565,-0.04894002,-0.058641307,0.014044515,0.04196165,-0.08885342,0.095545106,0.08269726,-0.000147643,-0.038896266,-0.11503229,3.588915e-33,0.027061712,-0.013345144,0.0035386854,-0.058707364,-0.06287837,-0.054823764,0.030195978,-0.020747086,-0.031931292,-0.0872181,-0.003392023,-0.046407185,0.02895254,0.041994166,-0.019425334,-0.022061495,-0.02319028,-0.035687476,0.028278029,0.03616025,0.042616386,0.03376849,-0.015568331,0.036183096,0.07011672,0.08209523,0.018111952,-0.037906926,0.004183983,0.02508108,0.1394249,-0.081139676,-0.09834436,0.037663784,-0.0021547573,-0.0090602655,-0.10254524,-0.03170079,0.012000338,0.07035283,0.03922444,-0.005144175,0.03306933,0.046992827,0.06268266,0.008808398,-0.07537347,0.1345307,-0.021446953,0.108986445,0.016908206,-0.031215006,0.002411618,0.019943358,-0.07556694,0.04243444,0.017119985,0.035086524,0.030210026,0.03419142,-0.040538717,0.1358332,-0.08493327,0.034384724,-0.017987136,0.0018833551,-0.034089614,-0.059544604,0.0023900429,0.034903873,-0.06948641,-0.0440789,0.009472303,0.056424517,-0.012693024,-0.09564418,-0.05421454,0.009318032,-0.017110232,0.036406644,-0.042248596,-0.007854638,0.0777599,0.01155642,-0.10354419,-0.04430792,0.005260059,-0.033932835,-0.065918975,0.0059179515,0.04984134,-0.07287177,-0.027974484,0.10544158,-0.0066462355,-4.5105445e-33,0.11198896,-0.050486207,0.09390104,-0.039029032,-0.07750536,-0.032470226,-0.037156455,0.019189514,-0.024558343,0.010246095,0.0851364,0.019977272,-0.012668424,0.012811371,0.025842618,0.0061928416,0.06386171,0.027487425,-0.052899957,0.03489675,0.023032725,0.028963225,0.009177661,0.044135615,0.07181456,0.015509326,0.008744759,0.0681615,-0.007744849,0.09207051,-0.026026601,0.028247815,-0.0049246177,-0.08118472,-0.04614283,-0.048654377,-0.04061485,0.017578097,0.027028734,-0.0034501206,0.037656024,0.049207725,-0.03265895,-0.0016469633,-0.040002916,0.06567277,0.04536065,0.02113941,0.0019109847,-0.08054515,-0.040459614,0.039875194,-2.750397e-05,0.015457136,0.033125278,0.04128216,-0.027165709,-0.025700543,0.02488995,-0.045364827,-0.03923018,-0.11501586,0.08775223,-0.011863577,0.052683547,0.027912349,0.039059713,0.04031427,0.05349779,-0.027274428,-0.0002372499,0.05844752,0.024419902,-0.012904839,-0.12102876,-0.03214699,-0.09654472,-0.025364932,0.01992002,0.010934132,0.071596645,-0.027898509,-0.040165883,-0.028077813,0.06798078,-0.104406655,0.028651904,0.13199785,-0.07287428,0.00293619,0.031141017,0.026739085,0.006023047,0.051417522,0.06616955,-3.684945e-08,0.0587071,-0.042552985,0.00044911366,-0.018496372,0.030853203,0.069361314,-0.06512125,-0.017081529,0.0140599925,0.0144686485,-0.015083566,0.041717876,-0.065691546,0.009265405,-0.012652815,0.012344334,-0.15307662,0.009945171,-0.021335533,-0.028630244,0.021831919,-0.05453604,-0.126179,0.00607686,-0.00538727,0.007139227,0.018582579,-0.01617953,-0.027283596,-0.040659603,-0.06315,0.025551366,-0.019217426,0.024934236,-0.043845665,-0.036451966,-0.010678236,-0.04845724,-0.06286027,0.0035520445,0.03416579,-0.036848955,-0.048048493,0.026527315,0.025107808,0.0033703889,-0.018557275,-0.00196401,-0.020155046,-0.075810745,0.0398752,-0.049798615,-0.006284032,0.014832071,-0.07886768,0.014470133,0.010859007,-0.05805953,-0.09081434,0.03240569,-0.028064197,-0.014565933,0.118947014,0.012330247 +2.4.1.356,"The enzyme, characterized from the halophilic archaeon Haloferax volcanii, participates in the protein N-glycosylation pathway. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60) and is alpha,omega-saturated. However, in vitro the enzyme was also able to act on a substrate with an unsaturated end.",384,1.0,-0.021314805,-0.013717381,-0.08087645,-0.038075995,0.010557283,0.0016427295,-0.11729054,0.0677581,0.08551716,-0.12428383,0.0027078895,-0.020949282,-0.06988174,0.060789943,-0.07238019,0.020543458,0.02524172,0.017765718,-0.023508895,-0.03891507,0.048377167,0.06064634,-0.031347573,0.01898595,0.0021239747,-0.023277448,0.023206566,-0.060201745,0.026000282,-0.04449107,0.005684536,-0.03572783,0.08003427,-0.033086434,0.029100629,0.080458745,-0.05144935,-0.06811423,-0.021189135,-0.008587874,0.031368118,-0.0121813165,0.025835773,-0.009775731,-0.08116839,0.012787105,-0.017302502,0.013911625,-0.016264183,0.076895066,-0.053936705,-0.10555507,-0.025663137,0.0042297067,0.042410117,0.11745011,-0.07610641,-0.032755956,0.034238815,0.01280694,0.035202745,0.07591699,-0.017381351,0.03831678,-0.06594304,-0.01526881,0.050375596,-0.08618033,-0.0150603615,-0.0786568,-0.052379895,-0.052937392,0.04567226,-0.0064588967,-0.023876205,0.03634194,-0.011005368,0.0060900254,0.04289527,-0.044816505,0.059962153,0.012855313,-0.0019952229,0.07153101,-0.014103826,0.04204054,0.018766318,0.030610302,0.046179507,-0.017337581,0.043475114,0.010321993,-0.0074295197,-0.09812502,-0.044910334,0.024467839,0.060036816,0.037125308,0.032648306,0.011919702,0.008242525,-0.0025796199,-0.014182216,-0.06250957,-0.11979726,-0.019053966,-0.0025403388,0.095525675,0.046066005,0.02302266,0.045621395,0.0020181872,0.07960214,0.003381354,0.00097085984,0.0030446434,0.034650426,-0.058349766,-0.104561925,0.041155346,-0.0051327506,-0.08643972,0.04311067,0.055628262,-0.032512013,0.026581842,-0.068865806,7.0815407e-34,0.1241236,0.017845485,-0.008194442,0.007236562,0.011960833,-0.0505552,-0.032139137,-0.013667816,-0.123307444,-0.076241985,-0.030166676,0.0079033235,-0.010584221,0.05806927,0.04407043,0.056486778,0.038918734,0.037620053,0.007467223,0.04150066,0.04830966,0.060225103,0.021919018,-0.028531391,0.04250896,0.061006647,0.013406539,-0.04814027,-0.0054682055,-0.01071103,0.0377308,-0.14207092,-0.076438606,0.08676476,0.08128118,0.092097916,-0.020904072,-0.03266265,-0.09199282,-0.009650619,-0.0037389135,0.06368631,-0.095865294,-0.044703074,0.079853766,-0.04676706,-0.012409322,0.025132328,-0.014102942,0.066677965,0.04754997,-0.012950457,0.053328812,-0.014590053,-0.056727104,0.075464934,-0.01712984,0.025474137,0.037846275,0.026483597,-0.041356158,0.055987347,-0.010292652,0.03903251,0.04702563,0.025470275,-0.06034301,-0.0054296716,0.005728966,0.040354557,-0.020536665,-0.031801827,0.023593588,0.06384176,-0.03808738,-0.10516622,-0.057501137,0.04068543,0.016804416,-0.024617149,0.031100746,-0.05256581,0.036003415,-0.038109973,-0.05569699,0.04743628,-0.012377632,-0.015864646,-0.024298323,0.03856138,0.053382736,-0.08823947,-0.03952136,0.0496716,0.0008328883,-2.3144852e-33,0.074087806,-0.13852549,-0.017180307,-0.013765587,-0.047440536,0.11413105,-0.010974517,-0.023789464,0.006939948,-0.058981523,0.062262274,0.06942511,0.041554336,-0.06816936,0.03797273,-0.050911862,0.04640141,0.06130146,-0.0039042816,-0.015244376,0.019514969,-0.011365596,-0.037203,0.007819331,-0.0066041276,0.02928532,0.012301514,0.08010861,0.006815096,0.023227474,-0.02450151,0.090031646,0.0040324447,-0.12951893,-0.01253004,0.03738087,-0.09052822,0.048742704,-0.0020920325,-0.04209037,-0.047090016,0.044460867,0.049966983,-0.023865247,-0.010799905,0.10572065,-0.04671139,-0.03239744,0.0938372,-0.057646487,0.037514523,-0.08543112,0.0042092227,0.022845598,0.011660916,0.032384366,-0.0068620043,0.03652917,0.009750018,-0.070508204,-0.081254266,-0.012344765,0.02765449,0.047284264,0.015780734,0.05386854,-0.045063753,-0.017768776,-0.05282562,-0.026497008,0.009121702,0.0032553659,0.04857186,0.10463032,-0.007600351,-0.038226306,-0.04641275,-0.02490307,0.015164585,0.0021742624,-0.019888582,0.027596531,0.011038662,-0.051570453,0.03679112,-0.115538724,0.08166737,0.115287565,-0.007928392,0.027808903,-0.022612413,0.020280987,-0.08808918,-0.047619525,0.10720565,-4.054288e-08,0.044248078,-0.032366205,-0.001969139,-0.05422341,-0.076179676,0.045077745,0.059067518,0.050184824,0.04724091,-0.049478456,-0.020920776,0.07453533,-0.0035131038,-0.023914538,-0.011328017,0.082325414,-0.022280155,-0.04745257,-0.026227824,0.030619873,-0.04526703,-0.0036638528,0.022218678,0.0046475492,0.0195274,-0.032168835,0.018756917,0.07656397,-0.022406926,-0.060848586,-0.05839308,0.061997026,-0.016720818,0.0032627606,-0.05579108,0.021847036,-0.009263871,-0.011550313,-0.0008618069,0.030425806,-0.0064510037,-0.012313637,-0.039992552,-0.026279405,-0.021780549,0.032896597,-0.0031172507,0.02059288,-0.039251056,0.06442855,0.013395809,-0.0063871676,-0.04865337,-0.11347433,-0.11396408,-0.03338395,0.07065048,-0.09642434,-0.057909694,-0.059211913,0.06687829,-0.056346785,0.18426877,-0.025526905 +2.4.1.357,Isolated from Malus X domestica (apple). Phlorizin inhibits sodium-linked glucose transporters. It gives the characteristic flavour of apples and cider.,384,1.0,-0.028943993,1.4704853e-05,-0.086680464,0.05495087,0.08243544,0.09833473,0.059274614,-0.011273198,0.061743826,-0.0803056,0.07478194,-0.021670915,-0.07115817,0.03864544,-0.016297733,-0.0021242585,-0.014208827,0.041239005,-0.013333957,-0.052512866,0.081941284,0.06088287,0.032708537,0.032610327,-0.05735651,0.020673903,0.013299741,-0.017079461,-0.018996462,-0.06735903,-0.02360274,0.027768562,0.027198672,0.021589207,-0.051700804,0.06859938,0.041712362,-0.06309573,0.01940813,-0.04051439,0.06151995,0.058489945,0.020402612,0.051334377,-0.0578431,-0.022998726,-0.11848504,0.02168913,0.07504425,0.06743976,-0.09390375,0.030979196,-0.02392671,0.0253475,0.019504052,0.0037900943,-0.059896644,-0.03913389,0.06927521,-0.0107919965,0.025527682,0.020715674,0.010509598,0.015408537,-0.095923916,-0.062114112,-0.025664859,-0.007267562,0.08114762,-0.08721657,0.010982479,-0.05816659,0.010921637,0.06611238,0.06789521,0.018234551,0.030608451,-0.027041413,-0.105551146,-0.018366057,-0.02270861,-0.01336733,0.06313347,0.1168305,-0.0062413993,-0.07365279,-0.0096780695,-0.022840448,0.016047422,0.04098763,0.05473525,0.042275805,-0.016445559,-0.010848758,0.019275893,0.07171636,-0.046285003,-0.14997986,-0.026871169,0.04445156,0.0056487545,-0.016659431,0.04761629,-0.036568154,-0.017864054,0.027565164,-0.009712153,0.010288066,-0.0042706095,0.006645819,0.056384835,-0.02483672,0.01701756,-0.07265771,-0.03636424,-0.015743779,0.017428081,-0.047370397,-0.0303651,-0.03547765,-0.008793511,0.016441008,0.027810058,0.00720499,0.015169481,0.03007291,-0.06512578,-1.05971e-33,0.00076086435,-0.06679229,-0.019891487,-0.014997992,-0.015908523,-0.068172276,-0.029165436,0.082120694,0.04724424,-0.078967676,-0.066939235,-0.03409321,-0.019693727,0.00093477964,0.0024576695,-0.056650903,0.02853845,-0.10132978,0.1462317,0.008422817,-0.03238915,0.019874014,0.0169808,0.025656614,-0.03302959,0.017524326,-0.049347818,-0.01910676,0.11230569,-0.009615106,0.09291464,-0.033786558,-0.03293247,-0.0074679353,-0.06530988,0.11520787,-0.045726594,-0.029137058,0.022876056,0.09032614,0.00014225881,0.04158846,0.04738005,0.040583003,0.048860334,0.015510815,-0.0999537,0.011366624,0.030990822,0.08439495,-0.042087536,-0.06864128,-0.015157936,0.046985663,-0.08672575,0.09444458,-0.03195089,0.018911855,-0.014823906,0.022440983,0.0046008877,0.0724938,-0.02799045,0.006763911,-0.0028247542,-0.01012848,-0.018182136,-0.079618745,-0.121441066,-0.034406558,-0.10204848,0.020920662,0.06575675,-0.0001947861,0.06510539,-0.082099006,-0.027575253,0.0184698,0.047798127,0.02829883,0.010567667,0.008130565,0.09177025,0.11089364,-0.12869923,0.05801097,-0.079238765,0.04008885,0.031982657,-0.034660805,0.022611508,0.03912074,-0.08753589,-0.009800163,-0.048848204,-1.0056504e-33,0.022499317,-0.08492324,0.09501873,0.0025268653,-0.018949803,0.054134145,-0.03183719,-0.039196003,-0.059993662,-0.0502441,0.033096563,0.023158178,0.04963726,-0.044959012,0.019945243,0.11120141,-0.008468999,0.08690603,-0.060576905,0.057787202,-0.084839545,0.09391384,0.037316617,-0.018457243,0.035939757,-0.06052911,0.033201948,0.037249133,0.012396127,0.018469667,0.034926448,-0.03650442,-0.07316653,-0.085964106,-0.010728218,0.0055633327,-0.13509193,-0.058152568,-0.045693085,0.04647353,0.03123524,0.038866516,-0.000762666,-0.027889002,0.097111836,0.11557957,0.021412497,-0.0032283699,-0.03085843,0.05131036,0.005512657,0.08206112,-0.0861611,-0.002060775,0.016763141,0.008488898,0.03232702,0.006688701,0.015601848,-0.029093917,-0.016272213,-0.014874257,0.044287138,-0.08888085,0.024841076,0.041604646,0.034089625,0.059020415,0.04279276,-0.024770109,0.09753701,-0.036723327,0.009027761,-0.032092545,-0.061813064,0.008207614,-0.023227122,-0.008033651,-0.049592897,-0.0057950765,0.022524605,0.08136285,0.022536492,-0.07488183,0.07047138,0.02472909,0.006827534,0.019428326,0.006781396,0.058986098,-0.023303658,-0.06585825,0.018274333,-0.018536113,0.0035804983,-2.6980013e-08,0.03272731,-0.039356235,-0.007248999,-0.012590514,-0.03402075,0.04905434,-0.021487925,0.006207302,-0.04733764,0.019040026,-0.019529177,0.04929937,-0.07485808,0.03622472,-0.026599288,0.049146906,-0.020701455,0.0728302,-0.008636451,-0.013929055,-0.11408324,0.048693363,-0.088211015,-0.003199926,0.019569336,-0.083889455,0.020518778,-0.08137694,0.054251146,-0.08543963,0.011290852,0.09571061,0.014724633,-0.040232774,-0.008578668,-0.01727683,0.01177504,0.014335936,0.019394362,0.05543202,-0.030273022,-0.044929657,-0.049580153,-0.018375032,-0.027768862,-0.012180991,0.084860735,-0.007127686,-0.001763273,0.02551859,0.036103453,0.028403632,0.016518788,-0.0049392423,-0.040487196,-0.017679984,0.0023799445,-0.14326067,-0.0029442934,-0.07416435,-0.029854482,-0.04060117,0.08092178,0.03964932 +2.5.1.144,"In plants, the activity is catalysed by a chloroplastic enzyme that plays an important role in chloroplast function and is essential for light-dependent redox regulation within the chloroplast. The bacterial enzyme also catalyses the activity of EC 2.5.1.47, cysteine synthase. cf. EC 2.8.5.1, S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent).",384,1.0,-0.08146069,-0.010327224,-0.032331936,0.031614,0.11771686,0.12675521,-0.034724183,0.024815658,0.06145318,0.01081024,0.03456136,-0.059266455,-0.015712118,0.028489627,-0.033874467,0.05628888,-0.135253,0.084947154,-0.03924411,-0.078745484,0.057833616,-0.028875092,-0.09712328,0.021367704,0.013813477,0.02473039,0.013138209,-0.03693006,-0.08307693,-0.08766143,-0.059694976,-0.0056345765,0.11289532,-0.027742997,-0.0034834403,0.1142059,-0.019878717,-0.16348831,0.024279565,-0.015339915,-0.045628123,0.025463043,-0.016694436,-0.034974407,-0.023496691,0.046093397,0.08099144,-0.0071426923,0.011288506,-0.11825461,0.013323021,-0.00041318726,-0.025117004,-0.008992641,-0.007016936,0.04255148,-0.044774815,0.0028088011,0.044548824,-0.052454602,0.022555867,-0.0111547215,0.010496234,-0.0038877465,0.009069511,-0.061682902,0.0070942366,-0.07651379,-0.050672162,-0.06691489,-0.065813325,-0.054292865,-0.02152524,0.043396328,0.013191242,0.021990685,0.0059762737,-0.046774007,-0.010685378,0.0035125944,0.048451345,0.0059733395,-0.04383426,0.041714806,0.055771388,-0.02352501,-0.008717794,-0.0062285457,0.055012375,0.031723544,0.058949888,-0.0028794764,-0.05233972,-0.024893021,-0.07432967,0.065826625,0.014148267,0.02074591,0.051782988,-0.07509765,0.017214222,0.10083594,-0.049049888,-0.058091987,0.049607523,-0.032154616,0.0094290385,0.08719653,0.0019024306,-0.009717305,0.010725428,-0.04101773,0.03286789,-0.03294484,-0.00015000447,0.09375631,0.0618863,-0.04643028,-0.12722896,0.06439368,0.04760301,-0.051039327,-0.029230837,0.069581784,-0.051035013,0.03469599,-0.11447066,2.188013e-34,0.06973741,0.020426646,-0.027827274,0.031610936,0.03185844,-0.04537649,-0.056925796,-0.006897462,-0.04618684,-0.121733144,-0.09765102,-0.009766333,0.036461517,-0.035021786,-0.027549233,-0.022115001,-0.032583896,-0.013772675,0.012513773,0.016718911,-0.00464859,-0.0270847,-0.017088909,0.027700804,0.055723574,0.014907827,0.046365768,-0.043795615,0.036200944,-0.017938264,0.01299038,-0.075692125,-0.04517511,-0.0054616313,0.07127023,-0.008427865,-0.041456863,0.0023929735,-0.006895617,0.062448215,-0.055562243,0.057837162,0.016041948,-0.019261373,0.034239296,-0.030693874,-0.05726865,0.113872275,0.049206227,0.05292803,0.047771238,-0.01867176,0.07323469,-0.026720582,-0.006683487,0.031150563,-0.005136219,-0.054186035,-0.02035717,0.074244775,0.024635738,0.10140839,-0.07598671,0.0069075213,0.053110242,0.07941348,-0.061465565,-0.033339348,0.005908721,0.04403103,-0.08317936,-0.042937636,0.06376707,0.052418016,0.054612033,-0.017017137,-0.06805052,0.017741792,0.04302481,0.05210834,-0.00534729,-0.015243411,0.034283638,-0.00259461,-0.036742307,-0.052569374,-0.002309144,0.0061302385,-0.08264749,0.039012257,0.11818367,-0.07085714,0.014144901,-0.015424364,-0.006734388,-1.7967303e-33,0.08201152,-0.11522503,0.033804335,-0.14197455,-0.010485812,0.07156935,-0.11089792,-0.06436012,-0.006718556,0.039046846,0.020910554,0.042973515,0.0063189887,0.0247301,0.002992396,-0.035220042,0.012532096,0.09080131,-0.085897975,0.019435447,-0.042490683,0.031327836,0.044887338,0.04208816,0.044849794,-0.00094851817,-0.02556803,0.08857851,0.044008315,-1.5593116e-05,-0.053746954,-0.035033215,-0.05148638,-0.0200118,0.022474673,0.070365384,-0.03488836,0.008781736,0.046787154,0.05601879,0.007900487,-0.026855256,0.028869146,0.03340755,0.03403971,0.05283247,-0.042436793,0.048717655,-0.0575051,-0.034247123,0.0077432706,0.025130687,-0.031482045,0.019002305,0.041378252,0.039573945,0.0037317965,0.045328338,0.01957739,-0.0023896326,-0.030250508,-0.049506184,0.0042222077,0.006014687,-0.004815188,0.047534384,-0.016242739,0.034542818,0.020453421,0.012317122,0.074457,-0.011058012,0.06144813,-0.013203738,-0.059249185,-0.0522266,-0.04427953,0.023715,0.017892476,0.019302232,-0.0036275107,0.003675609,0.026948702,-0.06688972,-0.03544353,-0.098482445,0.014355218,0.04446103,-0.0039531034,-0.013419286,-0.04797195,-0.020783156,-0.013120341,0.04893737,0.08111328,-3.9051645e-08,-0.014127062,-0.05469269,0.026613094,-0.09447147,0.013995394,0.05027555,0.027256047,0.0043902295,0.05918698,0.007054114,-0.0052491934,0.05501208,0.06953073,-0.05668476,0.059792776,0.020572772,0.023182975,0.02785679,0.0075895786,0.060704187,-0.03684561,-0.03864595,-0.1550723,0.041580573,0.032582223,-0.062416375,0.06110059,0.0025409965,-0.03649375,0.01748446,0.09666156,0.03287187,0.011031991,0.018703252,-0.06887272,-0.06030793,-0.035493355,-0.072248876,-0.037660997,0.046804268,-0.01913854,0.0032155572,-0.12717208,0.029202482,-0.0005921089,0.032323293,0.039293434,-0.008387418,-0.012573414,0.0330067,0.059107512,-0.060719524,0.0016014734,-0.055539433,-0.090213135,-0.0049710623,0.09436984,-0.048039358,-0.012066998,0.004782051,-0.022355871,0.04989692,0.19056113,0.03220641 +2.5.1.145,"This bacterial enzyme, which is associated with the membrane, catalyses the transfer of an sn-1,2-diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine of a prolipoprotein, the first step in the formation of mature triacylated lipoproteins.",384,1.0,-0.07935808,-0.08484116,-0.106893785,-0.028287657,-0.00077219325,0.033887204,-0.005758607,0.044503056,0.022056902,-0.05683311,0.07943134,-0.016465198,-0.00918386,0.053457607,-0.056841135,0.009224501,-0.05693657,-0.023266653,-0.010684445,-0.03084436,0.019762086,0.02174093,-0.055247467,0.012197156,-0.0016954078,0.012248892,0.0737939,-0.008660087,-0.11550078,0.018198172,0.030707873,-0.043358423,0.07068211,-0.028838431,0.10839961,0.05392349,0.019166883,0.03313992,0.025685892,-0.00072743295,0.025956605,-0.033497896,-0.011551661,-0.001994495,0.08078554,0.04524642,0.0149348,0.10586025,0.062032096,-0.009338366,-0.031547196,-0.059068426,-0.043671362,0.031006962,0.029043624,0.08783129,-0.06914136,-0.019539362,-0.03589319,-0.035575904,-0.013179881,-0.01541106,0.054202534,0.0042218664,-0.0017639996,-0.10852613,0.034831755,-0.059425924,0.043626927,0.01025266,-0.086408876,-0.02989485,-0.050631404,0.046978343,-0.047391318,-0.0040169973,-0.040239215,-0.050265107,0.035914645,-0.09307549,0.1263054,-0.028607897,-0.007887276,0.10701068,0.020738626,-0.028806057,0.020905063,-0.004296562,0.017401062,0.05038003,0.010259215,-0.049313225,0.05903415,-0.015551451,-0.13469724,0.0005615531,-0.03563673,-0.0049451753,0.035669804,-0.033668526,-0.0005639791,-0.021170849,0.074841864,-0.08048655,-0.027722055,0.042698693,0.00076782744,0.050343107,0.020533573,0.011279681,0.03228146,0.007201795,0.08783359,-0.06432266,0.015143078,0.091489725,-0.015858443,0.008936136,-0.080670744,0.037676457,-0.019861378,-0.038163908,-0.010415106,0.027986942,-0.029526882,0.0899631,-0.08310798,2.3720025e-33,0.051293097,0.03334999,0.0018904202,-0.011210107,-0.050584786,-0.047750417,-0.021586064,0.040751223,-0.039887067,-0.06496527,-0.023200113,-0.12513015,0.02817321,0.0096577,-0.04045246,0.011814313,-0.0029081425,0.05080109,0.121903144,-0.02590692,-0.04182867,0.0072310437,0.026780523,-0.08421638,0.09196576,0.02212952,0.021796308,-0.02664538,0.03891756,-0.0088697625,0.0056066336,-0.10325782,-0.030751344,-0.009446102,0.114630215,-0.0010266112,0.019605247,-0.019503808,-0.0022114078,0.054099064,-0.06647104,-0.00095733895,-0.017945427,-0.02821434,0.018926263,-0.010418736,-0.16568877,0.11600819,0.0020682425,0.013342721,0.024286028,-0.068871394,0.09527929,0.05098788,-0.020733235,0.00066361437,0.026437305,0.025224721,-0.0038019184,-0.06912667,0.0032141465,0.11163224,-0.14915226,-0.013254284,0.027611602,0.019559423,-0.07087666,-0.063225225,-0.028176831,0.037091747,-0.021544104,0.036753967,0.027746776,0.054987807,-0.013753103,0.019745126,-0.05068595,0.058907636,0.06481417,0.04190695,-0.05141381,0.025437878,-0.0003276528,-0.037329666,-0.02348338,0.019094814,-0.004419844,-0.02738687,-0.06760325,-0.0049710865,0.03392475,-0.074962966,-0.03717245,0.08556034,-0.013534566,-3.8705716e-33,0.026443204,-0.08083327,0.02527834,-0.03655867,-0.027033355,0.075647645,-0.0066996417,-0.030952932,0.04930081,0.002270266,-0.008963697,-0.024240397,0.043671828,0.022377657,0.06614456,0.028834462,-0.06737098,0.05019654,-0.022135885,-0.0585978,0.039950736,-0.018974422,0.013705838,0.14468402,-0.023501148,-0.017217422,-0.03316324,0.07680561,0.0017975526,0.13414736,0.0064352946,-0.06747043,-0.038766667,-0.06325619,-0.025662536,0.072655946,-0.047123212,0.043277845,0.053589575,0.025853718,-0.04817701,-0.004194646,0.04275735,0.0127505865,0.01644445,0.028124135,0.016207395,0.07003707,0.023227088,-0.04922249,-0.01839847,0.02358569,0.017960753,0.065324664,0.017383462,0.107834935,0.06736557,0.07004743,0.013544654,-0.12463676,-0.09518444,-0.11960464,-0.012697338,-0.02014632,0.039692037,0.10332695,0.00092722144,-0.06760206,0.036069345,-0.052452464,0.026681809,0.026191665,-0.0045256997,0.017273631,-0.031674173,-0.0030828093,-0.065817095,-0.016170392,-0.00042443088,0.041367795,0.016070126,-0.026913818,0.05679858,-0.045049995,0.010949197,-0.08353198,0.07820852,0.021959707,-0.0043005096,-0.012564968,-0.0047903825,0.009075118,-0.059915524,-0.045599412,0.011190546,-3.619924e-08,0.043161195,-0.076064266,0.01706,-0.07333169,0.035646733,0.030017525,0.046899926,0.031333312,0.057954762,-0.083938986,-0.014040915,0.10979503,-0.0041440367,0.009121781,0.083164275,0.036113713,0.025629347,0.002053196,-0.015145586,-0.08580728,0.025868574,-0.037686203,-0.09204026,0.014683145,-0.040080518,-0.078571066,0.030861922,-0.04343313,-0.0429806,-0.04377949,0.010593788,-0.0006042671,-0.058371708,-0.000914863,0.003642442,0.02157765,-0.06352922,-0.02050392,0.004276697,0.095555484,-0.00936487,0.033117842,-0.10164192,0.021331416,0.032179527,-0.025753113,0.01915869,0.02588804,-0.0584967,-0.008228007,-0.008357186,-0.047929883,-0.027130386,-0.050869618,-0.066840686,-0.0030255404,0.0104071265,-0.03212945,-0.022807665,0.029510293,-0.013599339,0.060322296,0.15451711,0.0013111534 +2.5.1.146,"The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids.",384,1.0,-0.097436726,-0.03807035,-0.06700838,0.047578007,-0.09376697,0.08237281,-0.057806026,0.029627252,-0.026589435,-0.0010706614,-0.022631824,-0.041632254,-0.053727195,-0.05123327,-0.06426673,0.11531393,-0.054713875,0.06925641,0.044514697,-0.026596403,0.08236947,0.05607555,-0.002743425,0.03922496,0.04645788,0.01957361,0.036000554,-0.00090776465,0.0060432837,-0.056362722,-0.03179181,-0.046714753,0.074803464,-0.05120334,0.08629674,0.029381627,-0.060761683,-0.09650053,0.11211323,0.03580756,0.05843621,0.0069385436,0.0017064958,0.12669854,-0.094844304,-0.01729434,0.043246407,0.05363844,0.022443416,-0.023890717,-0.03639702,-0.022128738,-0.020746123,0.024005963,0.009256688,-0.014644525,-0.08251198,-0.02142672,0.07163888,0.013134922,0.06685458,0.082720555,0.032782666,-0.015357422,-0.05888848,-0.033022538,-0.042115603,-0.068667285,0.050872535,-0.055130698,-0.0129349185,-0.09677061,-0.064339586,-0.03281402,-0.018513048,0.0015499354,0.05514689,-0.028634332,-0.06257219,0.0068593095,0.036518186,-0.0249901,0.09172207,0.044994026,0.010276808,-0.04059371,0.077794746,0.04523479,-0.025160376,0.02465154,0.07785065,-0.014197512,0.0024889994,-0.12436776,-0.035278436,0.03801052,0.01548834,0.0792727,0.034337252,-0.019555895,0.05860895,0.008331088,-0.018241137,-0.06445664,-0.033576936,0.002606796,-0.0017539923,-0.027756182,0.025925318,-0.01046839,-0.008478793,0.00783075,-0.010616943,0.01750043,-0.053702176,0.062292878,0.019966302,-0.061611783,0.0063580363,0.060218994,0.0013318509,-0.05822501,0.03360703,0.04819445,0.0026337206,0.021362549,-0.09434057,1.2975199e-33,0.027765116,0.03702227,-0.021716766,-0.05452758,0.03364905,-0.11857774,-0.046419617,-0.043624032,-0.095187284,-0.045047227,-0.09494998,0.04603534,-0.0047734,-0.0025701176,-0.02681746,0.09648906,-0.0554815,0.037917186,0.0886806,-0.020125886,-0.051501226,0.018362014,-0.06219025,-0.008757275,-0.04824028,0.09302345,-0.0008268379,0.021498406,0.03467212,-0.006751987,0.0220504,-0.111491464,-0.048992135,-0.004885641,0.017061511,-0.035760753,0.008796106,-0.018188305,-0.069668956,-0.004880807,-0.03969268,0.09133688,-0.019098286,0.0063034967,0.112246,-0.036182273,-0.037939616,0.022469725,0.074267656,0.038706332,-0.0478033,-0.043861866,0.12888485,0.007595798,-0.012629171,-0.020751996,-0.0024428095,0.10476891,0.03264639,0.04784842,0.0015209587,0.013233281,-0.016502267,0.028921071,0.054507405,0.021665303,-0.007922514,-0.021373034,0.021970654,0.06838064,-0.049431488,-0.0926844,0.054380838,-0.005644677,-0.010023265,-0.013709773,-0.02228255,-0.022021994,0.004200867,-0.018812504,0.012065295,-0.061716996,0.04109144,-0.021187916,0.008310923,-0.062140636,-0.08559888,-0.061985496,-0.015856303,0.08471932,0.008581884,-0.029910002,-0.09913356,0.07665903,-0.017268142,-2.659368e-33,0.1140195,-0.097033665,0.019453762,-0.07532495,-0.040813543,0.06200894,-0.0047863238,0.06246117,0.014210246,0.03643646,0.0988879,-0.057254765,0.055564933,-0.014271396,-0.05351238,-0.045674473,0.07469353,0.12955387,-0.061274998,0.013399378,-0.073688686,0.07805367,-0.0016833901,0.0054525873,-0.05673218,0.02879372,0.015502264,0.04512052,-0.029841768,0.04116459,0.00070338213,0.018798344,-0.044251483,-0.068336196,-0.0747669,0.03584783,0.0020607875,0.026304523,0.03789298,0.04806759,0.041201748,0.0339379,0.0061038504,0.04809072,0.0640036,-0.0026500588,-0.067974254,0.035952944,-0.029651593,-0.10254526,0.04785075,-0.00043754536,0.012039652,-0.012699173,-0.020528674,0.039762985,0.012886326,-0.014829798,0.034840595,0.01787844,-0.04498492,-0.053229585,0.03362728,-0.06429348,0.0019169555,0.09768413,-0.008886933,0.056701865,0.03076278,-0.004254214,0.0322057,0.049602054,-0.025657816,0.071633704,-0.055945434,0.020840902,-0.01858003,-0.13182339,0.011417937,-0.008338743,0.038466435,-0.027803086,-0.028129809,-0.012499685,0.011005982,0.012660093,0.04992485,0.10877109,-0.013127478,0.026826946,0.052388605,-0.005836439,-0.094250545,0.11007296,-0.015143589,-2.9411174e-08,0.07503463,-0.045717992,0.004442305,-0.017708637,-0.02240623,0.050187454,-0.01200283,-0.012490602,-0.005070851,-0.030986212,-0.002526096,0.035064787,-0.007957234,0.043086093,0.1060346,0.005540596,-0.02230172,0.00063171965,-0.009141279,0.046286274,-0.0615937,0.025669314,0.008524242,0.0075747278,-0.00940089,-0.06277611,0.070753396,-0.011097903,0.005763415,0.037399642,0.030521384,0.03413046,-0.03662274,0.05449202,-0.076841585,-0.0018563793,-0.029999826,-0.060680527,-0.013552407,-0.01788358,-0.0077837184,0.022699058,-0.101269215,0.006014358,-0.028441858,0.023475323,-0.039236538,0.034275465,-0.01861999,-0.05752256,0.0045740604,-0.088113286,-0.06783797,-0.059210807,-0.058271486,-0.009994901,0.008745817,-0.052556563,-0.045225423,-0.104934886,0.09466903,0.008314685,0.16086167,-0.028981708 +2.7.7.100,"Contains Zn2+. The enzyme catalyses the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea, by catalysing the ATP-dependent formation of a SAMP adenylate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage. The product of this activity can accept a sulfur atom to form a thiocarboxylate moiety that acts as a sulfur carrier involved in thiolation of tRNA and other metabolites such as molybdopterin. Alternatively, the enzyme can also catalyse the transfer of SAMP from its activated form to an internal cysteine residue, leading to a process termed SAMPylation (see EC 6.2.1.55, E1 SAMP-activating enzyme).",384,0.99999994,-0.09105794,-0.046932865,-0.06972505,0.055895768,0.08635976,0.02589277,0.016152926,0.008870769,0.025487807,-0.023128055,0.0007542545,0.028295575,-0.029362956,0.059067607,-0.05961881,0.033514224,-0.035305586,0.030742778,0.016968025,0.0062067476,0.07533471,0.06442895,-0.050976273,-0.022696747,0.046376046,0.015263758,0.064191744,-0.04326901,-0.00488184,-0.02962048,0.01721878,-0.055268057,0.019219114,-0.078623354,-0.015449315,0.11676878,-0.012749601,-0.036790095,-0.010822434,-0.09488777,0.06317751,0.030529687,-0.01948692,-0.007224042,-0.003795308,-0.006425394,0.01463642,0.040765926,0.0029701556,-0.004985086,-0.05762477,-0.021317527,-0.00015378043,0.039086927,-0.008053858,0.01496394,-0.112541355,-0.055998042,0.01247081,-0.078875996,-0.02772272,0.021652773,0.06376807,-0.07774443,0.09590499,-0.015640115,0.009666622,-0.022829905,0.06017936,-0.03728616,-0.05335471,0.022524541,-0.052426577,0.059757885,-0.06840894,0.029258797,-0.0016345872,-0.05360149,0.06032545,-0.01847837,0.021315511,0.030219316,0.024752248,0.09003367,0.059548844,-0.023216743,0.010962894,0.042559195,-0.033629265,0.028131377,0.07624568,-0.0022658,0.0037964564,-0.055074047,-0.060069676,0.0067113247,-0.06977588,0.026678825,-0.05443235,0.017747931,0.004801585,0.07916688,0.009958727,-0.15096042,-0.005719074,0.024756934,-0.012460156,0.07901213,0.029577812,0.06380632,-0.037966266,-0.013251838,0.018866591,-0.018182535,0.049767338,0.10151716,-0.024803795,-0.023008611,-0.100502364,-0.016071431,-0.080470495,0.019519353,-0.019720878,0.06405684,-0.0041857236,0.05125617,-0.13416538,2.8048138e-33,0.08029933,0.044139642,0.054227352,-0.031320922,0.04130894,-0.019597312,-0.04365237,0.026270865,0.0604662,0.0056683193,-0.058954366,-0.07215788,0.04191691,-0.06100347,0.00064562145,-0.066367716,-0.06529038,-0.027248695,0.10990763,0.015725827,-0.07970528,0.023455122,-0.021666797,-0.04300102,0.032269876,0.025535097,-0.03487861,-0.042916086,0.013267524,0.008972148,0.037248056,-0.06432634,-0.15933166,0.003576472,0.06903349,-0.037296187,-0.014625586,-0.0682181,-0.015337203,-0.013536422,0.053177867,-0.017805772,-0.038143635,0.059731886,0.037931606,-0.031057231,-0.049607255,0.111099765,0.0307005,-0.0056813024,0.05370557,-0.04383535,0.03861431,-0.03401789,-0.09326002,-0.019293701,-0.03651401,-0.0072463606,0.023643585,0.063628145,0.033658043,-0.038012214,-0.029951481,0.08210965,-0.04954365,0.012996809,-0.07116347,-0.038247038,-0.010698295,0.050342623,-0.0033477116,-0.05375305,0.11172066,0.025613789,-0.067400046,-0.06839085,-0.017564785,0.010763735,0.08112672,0.04960868,-0.09098927,-0.052619394,-0.058698405,0.0077970345,0.01534265,0.0005132386,0.016733466,-0.06276043,0.023261366,0.0024884602,-0.0114918575,-0.046800323,-0.073206626,0.066832475,-0.015331244,-4.042137e-33,0.080379955,-0.11032231,0.03927241,-0.06629258,-0.023814516,0.0342418,-0.00019866508,-0.016374184,-0.0046361955,-0.09757897,0.07579335,-0.04427915,0.089468144,-0.04338589,0.038123857,-0.028086502,0.033007007,0.06873898,0.028771501,-0.014999714,0.047839537,0.035620306,-0.0035782799,0.043162458,0.05844975,-0.007831988,0.026042841,0.079143524,0.06774629,0.120506555,0.076991536,0.0809108,-0.10894907,-0.061829496,-0.08410297,0.060066104,0.004161473,-0.011163333,0.004583614,-0.03372311,0.055960875,-0.01391086,-0.038362447,0.10564432,0.03607186,0.09750156,0.01151587,-0.0014574962,-0.022669913,-0.0973523,0.09397213,-0.02673433,-0.06643868,0.058307838,-0.02094187,0.11860803,-0.016255252,0.01955595,0.01085523,-0.030139681,-0.052254204,-0.029664718,0.017751347,-0.046924286,-0.018299194,0.014548735,0.09447719,0.020132784,0.04610734,-0.047072295,-0.0077365623,-0.00655353,0.042702258,0.045567453,0.00021300929,0.06199012,-0.0549673,-0.026391104,0.028498573,-0.09831249,-0.021357205,0.015207388,-0.039896343,-0.040433712,0.023905233,-0.022906858,0.041807324,0.14420478,-0.0062288363,0.014701522,-0.080212235,0.0142752025,-0.05823565,0.04447538,-0.050687194,-4.1701313e-08,0.015858894,-0.028903885,0.0585599,-0.027718453,-0.0050875754,0.083490364,0.016214214,0.028452136,-0.07205871,-0.063549675,-0.022972133,0.05579978,-0.02463047,-0.039483696,0.07236189,0.041628074,0.011104361,0.07098313,-0.022525566,-0.07828631,-0.025548082,0.0026654026,-0.012551724,0.07788143,-0.026037667,-0.015249635,0.041813698,0.014104793,0.015602979,-0.031028468,0.066070735,0.010917733,-0.0059175543,-0.02732448,-0.021274207,0.055985987,0.00677618,-0.09607142,0.004348102,0.0012019118,-0.082840435,0.026713144,-0.0824244,-0.0036581696,-0.011625433,0.023820559,0.008754987,0.05551002,-0.06800694,0.055968214,0.037429668,-0.05990351,-0.013048545,-0.07528247,-0.041440833,0.0072604595,0.011943637,-0.10703636,0.03148392,0.004004559,0.027366633,-0.00080179464,0.08276707,-0.035045177 +2.8.5.1,"The enzyme, which has been characterized from the bacterium Mycobacterium tuberculosis, has no activity with O-acetyl-L-serine. Requires pyridoxal 5'-phosphate. cf. EC 2.5.1.144, S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent).",384,1.0,-0.018138591,-0.11041609,-0.09486503,-0.039192524,0.06588835,0.054545272,-0.040181335,0.06044226,0.019595804,-0.00044413822,-0.006731522,0.038718652,0.03286456,0.07554214,-0.065667555,0.06710435,-0.016281953,0.0075114663,0.023704717,-0.012999979,0.05957228,0.075515285,0.031757444,-0.037227053,0.036660917,0.016570738,0.01757318,0.02215143,-0.09884751,-0.09677435,-0.021700744,-0.03315798,0.027146934,-0.06013293,0.1040121,0.023543295,-0.024325926,-0.028133929,0.06510149,0.03277107,0.02718371,-0.060512807,-0.061598223,0.008579136,0.00093826634,-0.030152299,-0.017305326,-0.0115624955,0.02747771,-0.003581226,-0.10513987,-0.03613632,-0.051744077,-0.009921291,-0.030665487,0.011514307,-0.032980718,0.0023239753,0.034598093,-0.0192167,0.013304884,0.03238122,0.041258335,-0.0027089955,0.04166954,0.003950701,-0.007914261,-0.10737074,-0.02682133,0.009025568,-0.08705757,-0.07547534,-0.03373034,0.12028324,-0.031987786,0.005087572,-0.04500897,-0.019559257,0.05087948,0.058255292,-0.05148378,-0.054516196,-0.07839808,0.036332272,0.041560955,0.014606373,0.07411721,0.035902917,0.08918015,0.024596151,0.020809697,-0.04900668,-0.050767303,-0.05202181,-0.007699561,-0.07111628,0.08442227,0.06500535,-0.081020094,-0.027271595,0.016714456,0.018043945,-0.025940608,-0.04422103,-0.055355925,0.0032549321,0.0056540724,0.03225648,0.010070349,-0.058835514,-0.03317197,-0.022168461,0.02152341,-0.04681875,-0.017838392,0.04788141,0.071109034,-0.064308606,-0.12481095,0.039284572,0.036317557,-0.048676968,0.022728264,0.10794554,-0.05227902,0.063523956,-0.0449989,-4.3396887e-34,0.07653632,0.028210247,0.10502033,-0.02336522,0.03450497,-0.014703491,-0.06691517,0.012506054,0.00086108356,-0.06589787,-0.07047466,-0.0593024,0.028523976,-0.008888127,-0.05651937,0.06051277,0.014407813,-0.05471609,0.12632596,0.04182347,0.06165702,0.005966018,0.000665603,0.11552384,-0.018200824,0.062100265,0.023298467,-0.0016044108,0.054496612,0.017458841,0.013724376,-0.10432351,-0.048940502,-0.051344004,0.02228198,-0.03477173,-0.071585156,-0.02907427,0.064531565,0.011559184,0.016999412,0.02857025,0.048219636,0.00367832,0.02031717,-0.050357074,-0.0510325,0.09528039,-0.032291707,0.023003744,0.042269327,-0.067205265,0.0018862146,0.002250074,-0.021081828,-0.012322282,-0.060141634,0.07642526,0.04276941,0.05036811,0.0852962,0.03856515,-0.021363506,0.05036198,-0.034188833,0.01136431,-0.036984757,0.0015506512,0.030459225,0.02298864,0.018895527,-0.0036110561,0.043849993,0.05083401,0.07389438,-0.019966396,-0.07766519,-0.012999852,0.07023214,-0.040838167,0.03418603,-0.0462517,-0.05525621,0.019564934,-0.027130555,-0.06418878,-0.038632292,-0.006954708,-0.058828365,0.01917395,0.03579271,-0.08675147,-0.03708983,0.06384614,-0.0072333836,-1.2037429e-33,0.07309708,-0.12399473,0.11821683,-0.07932457,-0.043013807,0.0306857,0.034624603,-0.048103012,0.063414045,0.02941027,0.075776525,-0.022015182,0.022384191,-0.028042873,-0.016942669,-0.016329318,-0.007867525,0.020108543,-0.02089004,0.0550901,-0.015549279,0.038275253,0.044884026,0.0073677734,0.05513204,0.07635212,-0.051081087,0.04047536,-0.0006921491,0.07242656,0.0073040603,0.07016468,0.013593412,-0.13158852,-0.124324195,0.037015215,-0.04200243,-0.010997877,0.014581158,-0.026211182,-0.023821402,0.044419866,0.002150613,0.015071623,0.018471837,0.008209351,-0.03976281,-0.029651852,0.025343368,-0.069504306,0.022877965,0.0077686585,-0.029299242,-0.07621696,0.03686707,0.06478737,-0.01611964,-0.020298162,-0.02318371,-0.057254676,-0.042859614,-0.011574192,-0.046373654,-0.018396547,0.051856656,0.09950216,0.023073316,0.083012335,0.089158915,-0.08102359,0.038437482,-0.015906384,0.068356514,0.0843724,0.028960304,-0.0036594633,-0.04000202,0.08345626,0.030554676,-0.033835977,-0.097612426,-0.012751041,-0.03617298,-0.10839828,-0.019184276,-0.07107482,0.021129174,0.07814193,-0.020937748,0.07736569,-0.029662881,0.04692756,-0.069647424,0.05007154,0.08536711,-3.5779173e-08,0.07077737,-0.033300243,0.102641754,-0.017192662,0.039429404,0.009694057,0.060585048,-0.003707308,0.12508151,-0.0096807275,0.015059801,0.054227345,0.04833856,-0.025195105,0.046910983,0.036664363,-0.015650002,-0.010049312,-0.007471157,-0.06161043,-0.050435144,0.0019085318,-0.060458474,0.045423664,0.020848487,-0.07876755,-0.006987796,0.026328685,-0.06837424,-0.005096614,-0.008622521,-0.0033024168,-0.018025313,-0.09517869,-0.122626014,0.0050945748,-0.030622594,-0.04505168,0.021205975,0.0299571,-0.045788012,0.0102730775,-0.051139377,0.016391665,0.045973822,0.034042086,-0.01771828,-0.021055311,-0.015179219,-0.042783674,0.041695785,-0.024104748,-0.04835047,-0.05726691,-0.052893545,0.08978849,0.027583621,-0.032506358,-0.030846879,-0.10358927,0.017686686,-0.050217368,0.118879326,-0.039668173 +3.1.6.20,"Contains Mn2+. The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. It catalyses two reactions in the pathway. In both cases the enzyme hydrolyses a sulfonate moiety that is bound (either directly or via a sulfane) to a cysteine residue of a SoxY protein, releasing sulfate. The enzyme from Paracoccus pantotrophus contains a pyroglutamate (cycloglutamate) at its N-terminus.",384,1.0,-0.067604944,-0.05169905,-0.04716998,-0.032389857,0.044640306,0.024312165,-0.045017596,0.03854564,-0.022275293,-0.007587454,-0.023876052,0.00022878667,-0.009688806,-0.0046325717,-0.055647627,0.052153233,-0.08218008,0.002441137,0.029649228,-0.03975207,0.08662799,0.08672752,-0.093142085,-0.051504437,0.040474933,0.15020733,0.035678383,-0.042240795,-0.054291304,-0.004300586,-0.04184506,-0.027731068,0.024048554,-0.035097566,0.06490534,0.038058612,-0.026779978,-0.03931898,0.09043785,-0.03840192,0.044181515,0.09139705,0.021901151,-0.030007064,0.0024261544,-0.008660028,0.03148593,0.0060320897,-0.0040638265,-0.02895481,-0.04198068,-0.06433176,-0.011563524,0.106777355,0.031105654,0.009805776,-0.051092412,-0.0073811007,-0.037991054,-0.016171966,-0.036146156,0.03720058,-0.08243916,-0.009863902,0.050285548,-0.08335932,-0.015049811,-0.015097533,-0.0052648233,-0.035896394,-0.046497256,-0.0059876735,0.04996768,0.061443236,-0.011334147,0.013891891,0.05319419,-0.05003806,0.07886892,-0.024997808,0.028727189,-0.006473796,0.012981441,0.10788029,0.025065357,-0.008646101,0.03944125,0.034608312,0.036902826,0.024756985,0.022743346,-0.037297443,-0.03124878,-0.07128536,-0.096825026,0.02292551,-0.055595577,0.06093635,0.045390923,-0.0015856996,0.0415598,0.024385761,0.025363749,-0.15834258,-0.008019519,0.03740466,0.05334636,0.11534067,0.02509948,0.08440131,0.031132141,0.05862526,-0.007519421,-0.031166617,-0.020226562,0.04978937,0.06254291,-0.04985098,-0.08231303,-0.049271088,0.017363971,-0.050195675,-0.01801035,0.03686188,-0.03884928,-0.011825907,-0.10998902,3.7756998e-34,0.065331966,0.010160155,0.024367386,-0.09616103,-0.025660189,-0.03157109,-0.022023197,0.05315826,0.0026489391,0.052970856,-0.11448656,-0.050497957,-0.006782792,0.03849584,-0.045771614,0.03174693,-0.051518384,-0.024351133,0.06867215,0.0025318263,-0.0026424644,0.04306558,-0.06929159,0.007634443,0.026054535,0.015878947,-0.00130527,-0.05253292,0.004560418,0.0106279785,0.091553934,-0.08287363,-0.07888464,0.0009071566,0.058057655,-0.009273424,0.011019692,-0.006340941,-0.043622434,0.050739184,0.01021291,-0.010277097,-0.05149354,0.0017512972,0.0052228877,-0.13185623,-0.06603571,0.074458055,0.031856664,0.065374225,0.046108566,-0.11411325,0.11119056,0.005389532,-0.020068398,0.048059992,0.04382909,-0.0015795343,0.101145685,0.06590252,0.015615887,-0.004811073,-0.021748353,-0.013874739,0.034880456,0.0124499025,0.005348319,-0.04502715,0.0034512344,0.05575456,-0.09531708,-0.09732945,0.008323112,0.027116802,-0.028857196,-0.05593395,-0.019783985,0.028081974,0.037950117,0.03585634,-0.0033060485,-0.11178036,-0.009891928,0.007974693,-0.11503953,0.03106209,-0.0060146763,-0.026290799,-0.060487002,0.010017032,0.035912436,-0.0070252446,-0.07462251,0.046648443,0.004999673,-2.9030723e-33,0.05304287,-0.087844715,0.026722714,-0.113523774,-0.092686646,0.027749551,0.04114594,-0.043040927,0.0062213466,0.016642408,-0.028684776,-0.017613348,0.04408039,-0.005283793,-0.008855486,-0.011540734,-0.010841648,0.09927453,0.005790842,0.014840489,-0.011224371,0.14046732,0.04991904,0.03599186,-0.012677742,0.008535994,0.003277563,0.07701729,0.031401284,0.11797509,0.00870956,0.006561751,-0.0023739925,-0.085567154,-0.056512967,0.07844909,-0.042627733,-0.0052816817,0.03014733,0.012731743,-0.002602848,0.0012778068,0.049018204,0.13779712,-0.012651529,-0.01784227,-0.030002343,0.07004499,0.014238431,-0.017181415,0.04402678,0.008267941,0.004832984,0.009738337,0.028624345,0.024890209,-0.084249415,-0.059252508,0.0077780704,-0.07622269,-0.1083464,-0.07452246,-0.05103749,-0.031553574,0.08178125,0.04009431,-0.016256627,-0.030481633,0.021299392,-0.026802177,-0.044018634,0.01431864,0.015160781,-0.0031403508,-0.06347678,-0.03167463,-0.08257709,-0.0035448521,0.017219197,0.01277612,0.022300627,0.030776333,-0.016296534,-0.11537835,-0.019869588,-0.017109878,-0.022383198,0.13097057,0.00048118978,-0.0060931826,-0.016148984,0.016313236,-0.013129205,0.0134617835,-0.038589817,-4.017541e-08,0.008482415,-0.0732982,0.055132616,0.023041947,-0.0286768,0.106408365,0.05602447,0.048358183,0.048322666,0.030385336,0.028869689,0.09971988,-0.07016678,-0.010836965,0.053861372,0.043099463,-0.0733112,0.028762799,-0.061046176,0.0035611417,-0.0075567765,-0.04729446,-0.08558135,0.08939558,0.066311635,-0.018835897,0.04481741,0.009365898,-0.041604195,-0.002788079,0.0017865655,0.06579079,-0.045459256,-0.06230924,-0.072970994,0.054846704,0.023420969,-0.02467124,-0.009310993,-0.037440136,-0.018136457,0.014406023,-0.1264233,0.0047534117,-0.044440195,0.011239113,0.023931684,0.06498482,-0.035215903,-0.02531762,0.0108947,-0.039051373,-0.00959641,-0.070965305,-0.09071412,0.012411604,0.027583253,-0.058705684,0.030384772,0.024459803,0.027419388,0.022258453,0.14545545,-0.008053078 +3.13.1.8,"The enzyme, found in bacteria and archaea, is involved in removing the (R) isomer of S-adenosyl-L-methionine from the cell. It catalyses a nucleophilic attack of water at the C5' carbon of S-adenosyl-L-methionine to generate adenosine and L-methionine.",384,1.0,-0.0770199,0.014895115,-0.006459533,0.059140436,0.08695151,0.06698197,-0.08428272,-0.009172295,0.04832377,0.05793702,-0.023043562,-0.047129724,-0.02591315,0.04900454,-0.079748586,0.038038675,-0.121560454,0.014959178,0.0029912384,-0.07537462,0.017861053,0.07356916,-0.054700106,0.033207912,0.11493098,0.0071090395,0.046161197,0.010373798,-0.05698538,-0.02907714,0.02228748,-0.06209635,0.10923178,-0.04373315,0.0441875,0.13142191,-0.06248205,-0.006101219,0.10680047,-0.019779885,0.026832271,-0.044204555,0.044926804,-0.0007032826,-0.0067232396,0.0052588214,-0.04610153,0.042497065,0.032170482,-0.034746036,-0.008837265,-0.07162902,-0.088234656,-0.020404471,0.017050825,0.024801735,-0.036313325,-0.04773663,0.03306026,-0.041459687,0.08053816,-0.042867966,-0.011179128,0.043323252,0.06471182,-0.11718629,0.03647105,-0.043650273,0.089905985,0.00115398,-0.024766736,-0.049192,0.0006098685,-0.014692925,-0.022498587,-0.058439955,-0.031348985,-0.046664808,0.059208512,0.0082048895,0.076798014,0.0058734994,0.042323157,0.06280276,0.024593432,0.048213396,0.015684735,-0.059365097,0.071268074,-0.055940215,-0.02469523,-0.020793285,-0.012073195,-0.08720363,-0.041133806,-0.015027522,0.02525085,0.016547838,-0.044258285,0.018878715,0.04012797,0.067552745,-0.10718372,-0.106064916,-0.027169405,-0.020863142,-0.0061476035,0.07181668,0.013036193,-0.0067040836,0.012815203,0.012457423,0.012920709,0.00477662,0.0040937676,0.09157761,0.08001587,-0.05554681,-0.07390535,0.03580871,-0.0634756,-0.08664823,0.014616593,0.043605372,-0.03821402,0.034244552,-0.06014186,9.445967e-34,0.07244474,-0.008688961,-0.023247998,0.00079552684,0.07414372,-0.052165788,-0.045030497,0.0045004855,-0.03020498,-0.021278992,-0.09104819,-0.053171,0.057574946,-0.03504675,-0.056494795,0.024074612,-0.045140374,-0.008402222,-0.00986439,-0.030040689,-0.066474445,0.005570125,-0.005509419,0.022529626,0.019852553,0.02170323,0.0030653246,-0.011815244,0.08738282,-0.010043914,-0.0247375,0.04727387,-0.10879515,0.053700037,0.059893098,0.040621784,-0.08844601,-0.042685308,0.03012603,0.10515844,0.002966114,0.052330874,-0.026998557,-0.073826216,0.048245996,-0.012363752,-0.044428077,0.09558591,0.030622413,0.082917914,0.061195217,-0.040709153,0.07374289,-0.025297925,-0.10868361,-0.01707656,0.0166457,-0.07183176,0.011236625,0.07527624,0.0073704524,0.037798204,0.0025206327,0.032407325,-0.020271413,0.03974596,-0.049143128,-0.03866057,0.06543066,0.062075168,-0.043532632,0.0060978886,0.0502715,0.057798665,-0.021730833,0.0071333474,-0.06344479,0.016685251,-0.0036288535,0.015797717,0.008339092,-0.039311834,0.04553539,-0.0017427184,-0.030973813,-0.02011278,-0.020921428,-0.08149245,0.008618026,0.04250228,0.077816434,-0.10155313,-0.039842658,0.003890366,0.00019907841,-2.5057378e-33,0.06305317,-0.11452895,-0.012391738,-0.0912644,-0.03484685,0.02342976,-0.037015185,-0.0853736,0.03464228,0.005397749,0.08391014,0.01426754,0.01640056,-0.0061601093,0.07302192,-0.060698576,0.067257114,0.024497984,-0.03894298,0.018082136,0.06867003,0.001928793,0.014450536,0.00089886534,0.053439118,0.010377409,-0.013993715,0.02409928,0.06882483,0.035005856,-0.057214104,-0.0019092449,-0.012014988,-0.014817687,-0.009255293,0.10485495,-0.0016564246,0.06962174,0.010566966,-0.025590295,0.039081484,0.056225725,0.0034203308,0.099813096,0.048123393,0.04514108,-0.035572153,0.018181322,-0.04344168,-0.1384113,0.035946455,-0.07598187,0.00932449,-0.02946205,-0.034322288,0.112247765,-0.008817007,-0.00242687,-0.028099045,-0.042417824,-0.041613188,-0.05999821,-0.021188019,0.0036524585,0.016761389,0.031778894,-0.023977408,0.048891444,-0.02508607,-0.06764841,0.023871709,0.008656064,0.07030202,0.04670007,-0.07233354,-0.045103893,-0.056869783,-0.02955673,0.010008024,-0.04332721,-0.015911212,0.029725801,-0.0075178244,-0.059422117,0.00014646824,-0.0761247,0.05507453,0.09074515,-0.002703579,0.044861116,-0.031658985,0.024469899,-0.043025784,0.020433925,0.074845195,-3.7034074e-08,0.07343969,-0.11570734,0.05066104,-0.043945644,0.033479597,0.114547,0.031958006,0.05258627,0.0736672,-0.051353432,-0.048220538,0.11261804,0.025301564,-0.008443875,-0.008409725,0.061750337,-0.0285592,0.0059905155,-0.042367216,-0.050445087,-0.10686602,-0.02727993,-0.06543053,0.025323104,0.011817288,-0.03179565,0.03448047,0.09544027,-0.059887838,-0.04874571,0.027915686,-0.020968065,0.0058870595,0.020849342,-0.055622164,0.014417586,-0.039816372,-0.060234353,-0.03466319,-0.006892617,0.0039551947,0.06796106,-0.074842155,0.032996405,-0.0115127135,0.012415631,-0.031138806,-0.0042943503,-0.037727237,0.034413822,0.06458452,-0.012261904,-0.037498463,-0.0112111345,-0.059087083,-0.057858717,0.006167711,-0.06391002,-0.04569998,-0.012506587,0.019066686,0.028247874,0.17044644,-0.037372127 +4.1.1.110,"The enzyme participates in an alternative mevalonate pathway that takes place in extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.99, phosphomevalonate decarboxylase.",384,1.0,-0.010451155,-0.00604576,-0.024032027,-0.034151286,-0.0045617484,0.04070202,-0.05403277,0.03784614,0.03560397,0.04858914,-0.0026636636,-0.058924444,-0.032458022,0.0658706,-0.07260704,0.0052224984,-0.060754556,-0.014201519,-0.030828062,-0.047459505,0.13374695,0.032823544,-0.054564428,-0.027064146,0.045914225,-0.007181015,-0.0006018876,0.032754794,0.022251714,-0.0410551,-0.01219838,-0.028417228,0.06268128,0.020534689,0.049321514,0.12759747,-0.056088027,-0.08002017,0.041961133,0.027059749,0.033868223,0.012530994,0.023500547,-0.010200227,-0.0632066,0.027281575,-0.008372271,-0.050155055,0.020438852,-0.003828586,-0.044843,-0.015909625,-0.013100045,0.062214885,-0.06717813,0.027636416,-0.013353903,0.03464082,-0.023207387,-0.008571377,0.042633027,-0.01211283,0.016703391,0.051719245,0.0122762,-0.010946774,0.05269795,-0.012240491,-0.023997147,-0.0200497,-0.02632252,-0.013511884,-0.024142597,0.0022770697,0.035558082,0.05836399,-0.0262865,-0.101593345,0.024424206,0.0024068686,0.07665398,-0.015194823,-0.012002594,0.009767811,-0.013182147,0.031766947,0.013987119,-0.018194295,0.05148332,0.06773935,0.0059014424,-0.10895098,-0.04476163,0.03178732,-0.023623517,0.033532783,0.018769603,0.030665506,0.04268726,-0.09284005,-0.013798065,-0.008213488,-0.028868536,-0.07511415,-0.008685276,0.00031461442,-0.05974043,-0.05381224,0.0138970865,0.044821486,-0.0012244147,-0.008882574,0.10136591,-0.004153918,0.026174074,0.11311005,0.003498207,-0.030739453,-0.064022295,-0.025053175,-0.024638737,-0.041665718,-0.006580859,0.050112695,-0.10376474,0.043975342,-0.14166081,4.550798e-34,0.02454115,-0.00048618525,0.042666644,-0.045644835,0.06707908,-0.073647484,-0.07778335,-0.0062727397,-0.09148888,-0.09866747,-0.02380817,0.026712248,0.04411186,-0.033023797,-0.04212274,-0.024978561,-0.021159247,0.042393196,-0.08562218,-0.018348046,0.0011408563,0.03313486,-0.0055978056,-0.011042932,-0.006202272,0.11074352,0.0065276236,0.02024292,0.034146674,-0.01750232,-0.008231947,-0.1286598,-0.09053127,0.044242043,0.09632024,0.058757722,-0.060889572,-0.051648967,-0.02435292,0.029031008,-0.00039527175,-0.005144151,-0.014256649,0.020241542,0.07689271,-0.10162407,-0.023931868,0.08216413,0.027055122,-0.000598279,0.0037645034,-0.016528312,0.060920928,-0.051842704,-0.08366641,0.0022373614,-0.038082577,-0.04094441,0.011011501,0.0038244654,-0.019691568,0.0001264746,-0.05587914,0.03249894,0.023271803,-0.0065201195,-0.097287364,-0.08244442,0.025329167,0.07950903,-0.037519183,-0.047626574,0.030360974,0.014836954,0.03317043,0.008885907,-0.029988486,0.019311933,-0.050267898,-0.019643223,0.010622637,0.028984107,-0.013113627,-0.025299177,-0.011130452,-0.028555028,0.06973705,-0.038213987,-0.004799948,0.0453394,0.0019824314,-0.106056266,0.048715513,0.07059612,-0.048226222,-1.9524359e-33,0.13830324,-0.089263864,0.058145124,-0.03275604,0.0055310996,0.07271488,0.07380363,0.009968389,0.012101986,-0.016266013,0.026933013,-0.017379193,0.04574121,-0.06067891,0.06426162,0.0066851,0.086797684,0.08157638,0.02639082,-0.045488946,-0.013254736,0.12975772,-0.020595646,0.030718308,-0.03702166,-0.05361963,0.0022922708,0.03322351,0.0054549435,0.062975086,-0.026480827,0.039346255,-0.038781337,-0.025244946,-0.055038154,0.05190784,-0.05271425,-0.04867586,0.06749868,0.051806875,0.018954571,0.029676812,0.019748352,0.0701684,0.026220344,0.051245738,-0.09715728,0.061962698,0.028154345,-0.07918316,-0.01888876,0.0039002316,-0.03373323,0.02353648,0.047415663,0.107043095,-0.059771705,0.050459668,0.009467945,-0.06369535,-0.08521426,-0.065961204,0.08519042,-0.011669842,0.012483195,0.10066669,0.006206378,-0.07143324,0.021788416,-0.04659425,0.08829972,0.037954733,0.00037559847,-0.0079731,-0.0005118018,-0.10664902,-0.13168706,0.019352026,0.06983931,-0.03132732,-0.06171696,0.06057698,0.02358309,-0.048859574,0.0695016,-0.14010398,0.014380693,0.08631462,-0.021950845,0.020977221,0.024339404,-0.042031083,-0.010671228,0.04221823,0.059331372,-3.0565662e-08,0.086211614,-0.037520558,0.022222618,-0.03799251,0.025225304,0.015692495,0.02658809,0.024451243,0.04560019,0.020854669,0.0589378,0.018807102,0.040995166,0.005650216,0.023659749,0.09050259,-0.03985996,0.013878494,-0.025642095,0.005428691,-0.03771657,-0.041231982,-0.06378622,0.04623264,0.02361773,0.08923962,0.06856384,0.03305668,-0.05187425,0.017013004,-0.047990337,0.049437273,0.005829755,-0.061976038,-0.11208219,-0.008148522,-0.022197198,0.03179673,-0.037547998,0.06827315,0.086733595,-0.02042993,0.0038091168,0.051482737,-0.028563412,0.026764369,-0.010305395,0.037032347,-0.00739176,0.06000122,0.0746228,-0.025906807,-0.022733226,-0.019841,-0.13607809,-0.085417435,0.0029685607,-0.029696956,-0.033756737,0.0097331125,0.046677854,0.048332725,0.1986876,-0.04707778 +4.1.1.111,The enzyme from archaea is involved in an alternative heme biosynthesis pathway. The enzyme from denitrifying bacteria is involved in the heme d1 biosynthesis pathway. ,384,1.0,-0.08833127,0.006212605,-0.047051143,-0.033835027,0.055799805,-0.022505507,-0.08057663,0.044175614,0.022061467,-0.009336611,-0.0667413,-0.05191111,-0.059188947,0.005239315,-0.035821423,0.026152395,-0.10345933,0.05900396,-0.038230255,-0.04430426,0.065057695,0.14289494,-0.057961807,0.037833914,-0.016150916,-0.02703726,0.10465921,-0.03264812,-0.03818771,-0.051707555,0.028979797,-0.0638482,0.07303253,-0.047086243,0.05010296,0.11792338,-0.009236269,-0.03903306,0.062439095,-0.035486,0.10001039,0.013454408,-0.012613033,-0.023032952,-0.054138467,0.04604777,0.025296373,0.006947429,-0.029283663,-0.0135203935,-0.024480406,0.0030976455,-0.07651686,0.028406087,0.031294692,0.07281917,0.026158245,-0.033382867,0.029924762,-0.08501214,0.047625635,-0.012291859,-0.0007498236,0.0096633015,-0.020245375,-0.0924679,0.077689014,-0.028265635,-0.021724576,-0.075168334,-0.02156478,-0.045258343,-0.052972376,0.011768297,-0.038044877,0.054412235,0.017411884,-0.03137833,0.040790446,-0.082473196,0.0626785,0.024444642,0.05635912,0.09520266,0.013297624,-5.5621487e-05,0.0101499725,-0.0527153,0.019433284,-0.02635657,-0.007740286,-0.05070701,0.047498398,-0.082761586,-0.046731893,0.014069356,0.03832495,0.05399186,0.03935285,-0.010359115,-0.06342467,0.05581792,-0.055735704,-0.07969145,-0.07487968,-0.05586845,0.0074315686,0.11359215,0.09382015,0.04117951,0.019334143,-0.047869913,0.11066015,0.06031957,-0.012027426,0.09207019,0.06748833,-0.04932973,-0.0592772,-0.00011448559,-0.013370897,-0.042636536,0.07339288,-0.02073081,-0.03353646,0.025193848,-0.12132662,2.7110593e-33,0.07359956,-0.01602184,0.013658775,-0.035193574,0.028056514,-0.041765746,-0.11733726,-0.02260343,0.028585022,-0.024503516,-0.082076564,-0.0959004,0.044289082,-0.0236194,-0.069305606,-0.011894591,-0.017742837,0.0137414755,-0.040432375,0.03806449,-0.018680263,0.067312725,-0.0414359,-0.026349483,0.049145162,-0.0072314967,0.040637955,-0.036763135,0.042576376,-0.013422984,-0.029351788,-0.08722691,-0.09203342,-0.0507445,0.09921881,-0.011834456,0.005055197,0.008698995,-0.098692425,0.02981309,-0.0145413,0.06529563,-0.044881877,-0.07604999,0.077152066,-0.029357264,-0.015097753,0.06748345,0.032743543,0.10812121,-0.020721752,0.009351569,0.16545773,-0.026589738,-0.028357493,-0.058467295,-0.036593873,-0.00052894215,0.109745726,0.023499466,0.045414656,0.0146470545,-0.021504069,0.09108179,0.09787337,0.0303895,-0.00023055215,0.0176764,0.029035931,0.030343367,-0.05097389,-0.010989019,0.0021314763,-0.0029414373,-0.056157302,-0.08115893,-0.055560384,-0.017247654,0.04919177,-0.06867979,-0.0404688,-0.028959915,0.014591911,-0.025192976,-0.0051660375,0.022787476,-0.030008597,0.003678813,-0.053712953,-0.022122739,0.07576192,-0.0788122,-0.06196288,0.025287723,0.041098118,-3.55674e-33,0.04165985,-0.06710075,0.0072824764,-0.09954768,-0.026802583,0.0926076,-0.016854418,-0.03676208,0.017506517,-0.0040799025,0.051745612,0.030811295,0.003170858,-0.029212655,-0.012925013,-0.03600996,0.031055672,-0.004596292,-0.052672654,0.018403156,0.09805065,0.030044379,-0.050877035,-0.045286253,0.046800397,0.02529471,-0.027329737,0.15020482,0.009892246,0.015477584,0.017319199,0.08806706,-0.042147465,-0.05853394,-0.07223296,0.045527466,0.005059413,0.031807855,0.008943037,-0.05215437,0.01823658,0.028505782,0.04096769,0.09404686,0.03870146,0.046464648,-0.08257667,0.06294015,0.0274543,-0.02524912,-0.015236236,-0.026393237,0.010990678,-0.004590393,0.004250363,-0.01439804,0.04066872,0.07681905,-0.06386801,-0.0156240035,-0.050843745,-0.02384433,0.066409335,0.0072732735,0.014854049,0.035379063,-0.06526006,0.0856458,-0.0023567905,-0.045478363,0.025852252,0.034464736,0.04373123,0.02967288,0.022174096,-0.07320556,-0.03073302,-0.056495525,0.06431444,-0.0066485987,-0.053585354,0.0030248554,-0.014149505,-0.06254919,-0.006470841,-0.040187635,0.009797936,0.035860654,-0.052859336,0.015017865,-0.0910194,-0.066591084,-0.009879341,0.04486692,-0.018276272,-2.8354862e-08,0.039243434,-0.043196023,0.054992646,0.012497883,-0.021596259,0.029725183,-0.009119014,0.10944498,0.03480412,-0.022643734,-0.0018129922,0.05064005,0.036767486,-0.0006034018,0.070813306,0.07628889,-0.0008246541,-0.0053130453,-0.057305485,-0.042981558,0.0064844233,-0.02929671,-0.050509878,0.07157042,0.061187804,-0.06722462,0.02130171,0.00132893,-0.011494318,-0.06769185,0.0021134994,0.046932388,0.027527465,-0.027284376,-0.007966554,-0.0003316478,-0.017002877,-0.0092251785,0.018509453,-0.03544261,0.010856701,-0.022892173,-0.10631523,-0.004747936,0.003802521,0.038966626,0.006683943,0.050624866,-0.050323747,-0.015528954,0.0210271,-0.029394554,0.0659986,-0.03449234,-0.08109337,-0.005035502,0.042850416,-0.036263485,-0.010773842,0.045940932,0.08512774,0.015516935,0.18426666,-0.02433644 +4.4.1.37,"This enzyme, found in Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. The process starts when one enzyme molecule adenylates pyridinium-3,5-dicarboxylate mononucleotide (P2CMN) and covalently binds the adenylated product to an intrinsic cysteine residue. Next, the enzyme cleaves the carbon-sulfur bond, liberating pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide (PCTMN) and leaving a 2-aminoprop-2-enoate (dehydroalanine) residue attached to the protein. Since the cysteine residue is not regenerated in vivo, the enzyme is inactivated during the process. A second enzyme molecule then repeats the process with PCTMN, adenylating it and covalently binding it to the same cysteine residue, followed by liberation of pyridinium-3,5-bisthiocarboxylate mononucleotide (P2TMN) and the inactivation of the second enzyme molecule. cf. EC 4.4.1.45, extrinsic cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase.",384,1.0,-0.030213872,-0.09046287,-0.05962293,-0.045636,0.058936942,0.031995136,-0.073086046,0.043883007,0.02463083,-0.014882016,0.08964345,-0.030878285,-0.103684254,0.0050842767,-0.061474815,0.03295818,-0.07781752,0.03854511,0.017692527,-0.047372784,0.055079054,0.04145345,-0.06124304,0.022974744,-0.014560773,0.034988075,0.097810015,-0.05665748,-0.06967331,-0.0348911,-0.01708532,-0.11057486,0.00074954843,-0.014993705,0.025276655,0.07440354,-0.039249994,-0.066766635,0.042404447,0.0053311386,0.079553336,-0.022761064,-0.020545855,0.014031807,0.020808553,0.02361642,0.057170447,0.03943472,-0.002621922,-0.06433348,-0.0035218678,-0.03541821,0.058072664,-0.022494016,0.027949316,0.0024672938,0.015851963,-0.017991144,0.01106273,-0.015053521,0.064074546,0.008426495,0.015207589,-0.023535728,0.07692917,-0.021763423,0.071125016,-0.08964585,0.002275607,-0.009048557,-0.054723192,-0.044371735,-0.0013592759,-0.0026523203,-0.001419362,0.03947132,-0.022984046,-0.023622256,0.03674317,-0.007814671,0.025360823,0.029041,0.01990993,0.06912552,-0.0061219246,-0.04099576,0.06634017,0.042204123,-0.009533436,0.00085841236,0.009687227,0.03141208,-0.029818786,-0.008472351,-0.12881419,0.014944515,0.000119933866,0.10168755,-0.0029321807,-0.0507935,0.042000048,0.064525165,-0.118167296,-0.11712023,-0.07284904,0.0014828715,-0.003954804,0.103861704,0.06740414,0.07740446,-0.03584464,0.018040568,0.013338267,0.006974364,-0.04605686,0.10385569,0.016951071,-0.03526096,-0.010034508,0.0722071,0.034416985,-0.019919615,0.0531155,0.053385004,-0.044406343,0.02261908,-0.08529705,5.877038e-33,0.04574411,0.0048923963,0.04681889,0.004009655,0.05779697,-0.041056298,-0.09543573,-0.004181684,-0.081329666,-0.033685002,-0.025045954,-0.08472098,0.03896941,-0.06466468,-0.060816284,0.0013957915,-0.10829203,0.031161211,0.08269547,0.034774635,-0.01039419,0.038875863,-0.067380145,0.08235732,0.024660366,0.10040726,0.008775408,-0.00066739117,0.043607276,-0.010983123,0.03527416,-0.10789689,-0.06806281,-0.030989464,0.09361637,-0.100615464,0.054057904,-0.015327693,-0.029610006,0.01600123,0.005254796,0.006225598,0.055253036,-0.04115995,0.033347577,-0.06303795,-0.06277832,0.11337694,0.0070757484,-0.012634101,0.10599795,-0.0051236153,0.072622605,-0.0073956,-0.059300486,0.015461892,-0.06009823,0.012057026,0.059418835,-0.039575346,0.066270955,0.058783222,-0.066039234,0.014173825,0.005410001,0.063329205,-0.06437878,-0.03941582,0.030111723,0.06285202,-0.08155576,-0.07022173,0.03512149,0.030371845,-0.007079678,-0.017324697,-0.05459811,0.017915146,0.005445971,0.007408871,-0.075213715,-0.027398057,0.0023961277,-0.037919644,-0.026429007,-0.07880987,-0.07392441,-0.03859362,-0.017739609,0.024457958,0.026046854,-0.051597264,-0.07387289,-0.0013304836,0.0073245484,-7.286502e-33,0.08191251,-0.07207432,0.03355048,-0.04216944,-0.025441283,0.0016518616,-0.021090599,-0.041235335,0.03295114,-0.085398905,0.07009044,-0.034949932,0.04415974,0.04496135,0.020302445,0.06960742,-0.015898634,0.114761524,-0.034696016,-0.000573748,0.08510777,0.02035837,-0.0100825485,0.017531747,0.012884475,0.050422203,0.0012085926,0.037176598,0.07257614,0.006781287,-0.009722956,0.045268,-0.056064416,-0.077168845,-0.092085,0.016557284,-0.039657157,-0.060816966,0.057811067,0.048175797,-0.01992514,0.031091832,-0.016217768,0.04962045,-0.0023616804,0.01159863,-0.04326072,0.00205327,0.025925195,-0.02285603,0.06618671,0.021835275,-0.033462264,-0.019809715,0.021493657,0.08638698,0.018367933,0.0058377357,0.040070865,-0.015826553,-0.085805446,-0.058295727,0.052836526,0.0027087685,0.008151137,0.020626893,-0.030908067,0.03622669,0.07175964,-0.04178386,0.02156666,0.0932274,0.02943821,0.03284315,-0.0789563,0.033855084,-0.052773293,-0.0070872772,0.0008214862,0.00976392,-0.008336037,-0.025037937,-0.0021744866,-0.02300759,0.04410875,-0.07640508,0.06590407,0.14221123,-0.02496695,-0.037762504,-0.047982223,-0.040779427,-0.014968384,0.08541625,-0.015208471,-5.4978216e-08,0.016986959,-0.06463246,0.014420243,-0.051009975,0.0111981,0.07181534,0.017688489,-0.019152908,0.031723846,-0.09270399,0.051154964,0.09470134,-0.08138277,0.042615213,0.07327422,0.007733946,-0.017987972,-0.04037352,-0.017539866,0.003029031,-0.10500876,-0.03590118,-0.11329914,0.029442241,0.001833509,-0.047619633,0.07269595,0.06547902,-0.032044068,-0.014057052,0.006552372,0.036235623,-0.012932775,-0.031119525,-0.06301086,0.033900395,-0.121305496,0.027794486,-0.011291531,0.03235232,-0.020782402,-0.019923946,-0.10035365,0.013463085,-0.010232413,-0.013875623,-0.043619018,0.07648693,-0.07504528,0.028928675,-0.020319333,0.012299098,-0.03131988,-0.01929086,-0.044737343,0.070579834,0.088048935,-0.075753845,-0.017608825,-0.0370834,0.017368203,-0.0069852895,0.17599212,-0.0040681716 +6.2.1.55,"Contains Zn2+. The enzyme catalyses the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea. SAMPs are involved in protein degradation, and also act as sulfur carriers involved in thiolation of tRNA and other metabolites such as molybdopterin. The enzyme catalyses the ATP-dependent formation of a SAMP adenylate intermediate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage (reaction 1). This intermediate can accept a sulfur atom to form a thiocarboxylate moiety in a mechanism that is not yet understood. Alternatively, the E1 enzyme can transfer SAMP from its activated form to an internal cysteine residue, releasing AMP (reaction 2). In this case SAMP is subsequently transferred to a lysine residue in a target protein in a process termed SAMPylation. Auto-SAMPylation (attachment of SAMP to lysine residues within the E1 enzyme) has been observed. cf. EC 2.7.7.100, SAMP-activating enzyme.",384,0.99999994,-0.09615597,-0.046932444,-0.035812035,0.040048525,0.07558977,0.020499196,0.016201872,0.012345669,0.03439759,-0.0049502514,0.011555986,0.040906597,-0.026822902,0.08216065,-0.06799701,0.031337693,-0.03103977,0.0067510814,0.004293722,0.00011514673,0.08422568,0.048886344,-0.067145914,-0.031227617,0.054905634,-0.007749322,0.05296189,-0.021321956,-0.019103061,-0.052589715,-0.014724224,-0.09105032,0.009467691,-0.071335785,-0.018415479,0.12280724,-0.02861298,-0.02877542,-0.0046225474,-0.098297894,0.06633523,0.03386688,-0.02750044,-0.014275683,-0.020726038,-0.00093117583,0.025253192,0.034613725,0.0035796377,0.004694197,-0.044612028,-0.017879477,0.015998282,0.028327923,-0.0019180027,0.008790851,-0.12251759,-0.021732476,0.015436182,-0.07622151,-0.035312492,0.0218332,0.04573279,-0.07256947,0.091821894,-0.035624564,0.025877414,-0.05457969,0.05921015,-0.010542842,-0.06995295,-0.0045094714,-0.058248285,0.046607826,-0.035463803,0.040897686,-0.022435632,-0.04631944,0.051786885,-0.03664715,0.026345119,-0.0067503657,0.023838067,0.053768862,0.04350798,-0.01904666,0.0012922458,0.044049013,-0.014838712,0.004292991,0.07775655,-0.011486618,0.023568658,-0.023442077,-0.019238263,0.00053546275,-0.047613997,0.032552365,-0.061985254,0.019084562,0.021636195,0.11443012,0.00054519216,-0.11897416,0.016794479,0.022330951,-0.013722479,0.08860774,0.022536231,0.057916846,-0.0420528,-0.015155201,0.024044748,-0.022726897,0.023713918,0.13112614,-0.037251342,-0.012172852,-0.08554504,-0.021627627,-0.06599926,-0.0030238295,-0.015476511,0.07685596,-0.0057727294,0.052277274,-0.11432523,3.6679152e-33,0.08166363,0.040097732,0.039483435,-0.04005774,0.03358694,-0.03967803,-0.06549632,0.04277242,0.050703783,-0.03157643,-0.059311733,-0.046661694,0.05750348,-0.06819543,-0.033398245,-0.055250436,-0.04610412,-0.016927946,0.11190997,0.024077369,-0.07141905,0.010844164,-0.020644447,-0.04870753,0.035627104,0.03505589,-0.019194612,-0.00018509875,-0.0015737928,0.018078087,0.018074874,-0.080072455,-0.16853987,-0.0029594288,0.042705253,-0.07092623,-0.024121182,-0.058577158,0.030464176,-0.014279327,0.03406701,0.005075738,-0.021126963,0.050299596,0.041610222,-0.0555212,-0.018045,0.13588005,-0.0025577014,-0.004252549,0.07328705,-0.054817323,0.05094028,-0.027854128,-0.101200745,0.0030659975,-0.016267108,-0.0054345788,0.022575134,0.0723313,0.055853736,-0.0026959872,-0.023074575,0.062402252,-0.024570294,0.03194448,-0.07956086,-0.043404706,0.002619336,0.06214218,-0.02062608,-0.06825906,0.1132661,0.016901528,-0.053938735,-0.06521743,-0.0087868115,0.025643589,0.06649942,0.054636147,-0.099130385,-0.032717124,-0.07250005,0.013809718,-0.010450621,-0.020380318,0.023018816,-0.08390481,0.010809121,0.018214468,0.0045321356,-0.049318824,-0.0685644,0.07615338,-0.00043296537,-4.7426873e-33,0.090738125,-0.08456279,0.024674134,-0.056987703,-0.021797344,0.02246124,0.01912865,0.0009843395,-0.0026261797,-0.09916753,0.055572905,-0.037002962,0.08727078,-0.03327022,0.037082672,-0.020614067,0.016615018,0.064986214,0.032854486,-0.0025005508,0.05521144,0.045255516,0.002179027,0.04165621,0.044951953,0.005446254,0.018524822,0.07802953,0.06261375,0.10587525,0.06316241,0.06961635,-0.116640605,-0.03316633,-0.07886969,0.055866443,0.0022802844,-0.018394256,0.024872102,-0.03591111,0.08999629,0.00096914294,-0.025091026,0.113107994,0.052801352,0.09061248,-0.007014532,-0.0040768394,-0.049755294,-0.10904503,0.050727323,-0.003809782,-0.07225404,0.07382826,-0.037315365,0.15369739,-0.0009520372,0.032303877,-0.015963897,-0.009503762,-0.036841743,-0.026380096,0.021515649,-0.039711915,-0.011186104,-0.003006032,0.06193581,0.03103618,0.0542264,-0.038584825,0.013809652,-0.0259704,0.040673245,0.029594455,0.004572937,0.0713356,-0.05631204,-0.03200201,0.014679452,-0.107095316,-0.045078162,0.040222734,-0.06508028,-0.037590437,0.02177673,-0.047005262,0.030099507,0.1796291,0.0049052336,0.0058050915,-0.052041885,-0.005798286,-0.05100401,0.06333598,-0.04212518,-4.494718e-08,0.023571787,-0.018551474,0.073622994,-0.023581564,-0.008236335,0.07250575,0.0015525864,0.044812255,-0.05842488,-0.05131625,-0.033527926,0.060248166,-0.03881887,-0.04296454,0.026585937,0.074285276,-0.014591217,0.063263714,-0.025361594,-0.062879466,-0.03970371,-0.002559411,-0.039722364,0.070746675,-0.024021525,-0.007239036,0.048987795,0.023695977,-0.028897326,-0.040669575,0.060877364,0.01772113,-0.0071090823,-0.032005552,-0.031277437,0.043191507,0.0011046054,-0.07982539,-4.49838e-05,0.0031077643,-0.07634996,0.011390643,-0.09814949,0.0071461713,0.02110558,0.033449676,0.008550303,0.044031255,-0.07021878,0.042855952,0.033075396,-0.06348002,-0.031740654,-0.09403241,-0.028808229,-0.010010515,-0.023201723,-0.09942069,0.048660565,-0.0039405515,0.025337432,0.009336617,0.07261756,-0.04962858 +1.14.14.88,A cytochrome P-450 (heme-thiolate) protein. Also acts on biochanin A and other isoflavones with a 4'-methoxy group. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.,384,1.0,-0.07782193,0.010522653,-0.10701498,0.016459972,0.014799508,0.06921986,-0.02609699,0.06836112,0.028999176,-0.07092877,0.010298666,0.0018078657,-0.065557346,0.0015760559,-0.04441172,0.034554824,-0.07977955,0.015726727,-0.00021062088,-0.052646097,0.0012387742,0.01578183,0.03331673,0.03285455,-0.0685072,-0.015071637,0.027247539,0.10801637,-0.009760226,0.019842643,-0.052218404,-0.019094048,0.027698534,0.013654598,-0.020119825,0.14250295,-0.08485511,-0.024295129,0.043709077,-0.060062476,0.14393987,-0.051885962,-0.031206062,0.052068044,0.03593735,-0.062387146,-0.013721251,-0.0010011608,0.052480295,-0.038323354,-0.071398675,0.009861789,-0.030980768,0.037443604,0.0053110393,-0.03220078,0.047722276,0.00010026408,0.025150016,-0.06633445,-0.028062003,0.016395532,0.03282457,0.0035024348,0.015281316,-0.055797275,-0.060231548,-0.0045386376,0.015381292,-0.08024635,0.004015145,-0.066563405,0.011892734,0.04141784,-0.035281688,0.10965329,-0.104411356,0.015661541,-0.051233534,-0.036771044,0.06594215,0.0014344584,-0.0013622057,0.15490516,0.016961684,-0.029608056,-0.034465384,-0.005952625,-0.05105478,-0.04128852,0.053175613,0.057572357,-0.010564344,0.015164021,-0.07412561,0.01916565,0.0536844,-0.00639828,-0.047635425,0.01381074,0.006788742,0.047785804,-0.10516743,-0.06561617,-0.0200134,-0.009543707,-0.012844912,0.055530913,0.08526699,-0.056753673,-0.05603571,-0.06806698,-0.00011245591,-0.053373013,0.016389647,0.04811074,-0.026990872,0.006226976,0.058473546,-0.020957315,-0.028484553,0.007868824,0.013347483,0.008046532,-0.024296168,-0.013842284,-0.09926778,3.541256e-33,0.09098141,0.028414417,-0.012182518,0.03777527,0.0342092,-0.03423299,-0.059747156,-0.06454759,0.039733764,-0.00696189,-0.106824785,-0.049920466,-0.028076448,0.0047811824,-0.05369189,-0.030425746,-0.07937242,0.020162744,0.070169106,0.0035282876,-0.0398716,0.007488792,-0.0650641,0.01944799,-0.008670592,0.096184514,-0.074440025,-0.021594305,0.0017399734,0.023013182,-0.06349608,-0.022681808,-0.05776653,-0.07935001,0.006490607,-0.033790726,-0.025723223,-0.04885132,-0.09685496,0.011875427,-0.07310333,-0.05808444,-0.014535063,-0.0883697,0.076979406,0.019284077,-0.12533791,0.07588053,-0.0076071713,0.02187187,0.06444347,-0.08236492,0.13372675,0.031229815,-0.08144792,-0.027954945,0.010728519,0.0019868177,0.019943904,0.06897699,0.112657554,0.018828072,-0.01223086,0.05054038,0.024506131,0.06300736,-0.025030492,-0.016273957,-0.0042852196,0.1443094,-0.03701906,0.053999115,0.013345459,0.0100641735,0.03404787,-0.0014523638,-0.030166253,0.036951777,0.0006368387,0.05063348,-0.010036601,-0.037996233,0.0022338678,0.022981962,-0.02521864,0.0111536365,0.019105157,-0.015023333,0.024939707,-0.0024538313,0.042500403,-0.046221,-0.004221739,0.019676045,-0.03571597,-4.7106544e-33,0.03095388,-0.0152217755,0.0148911085,-0.05959248,-0.05922843,0.02101692,-0.0675061,-0.024964621,-0.0054168776,0.032154486,0.096048035,-0.09132559,-0.009200211,-0.0022209925,-0.029568974,0.08075622,-0.019099066,0.035896253,-0.014441999,0.024451867,-0.051568802,-0.025864502,-0.004997037,0.11168942,0.07784654,0.031167446,0.046237633,0.0133905765,0.043862265,0.019516803,-0.045292154,0.058061972,-0.055884354,-0.016330121,-0.035851113,0.10277794,-0.008841932,0.03480636,0.055943653,0.057289753,0.056876037,0.04438215,0.018735584,0.043396175,0.010786252,0.058057517,-0.02411386,0.014863901,-0.016173214,-0.053630937,0.067030914,0.033223655,0.036740698,0.024718396,-0.018855928,0.043966666,0.008083726,0.0027000685,0.02737254,-0.05959992,-0.044298872,-0.08008533,-0.040200118,0.08770835,-0.0024338556,0.051220525,-0.01247893,0.009592094,0.025416506,0.0060190624,0.08311428,-0.009037435,0.09971345,0.09827236,-0.012077164,0.023734614,0.038022857,-0.0078306915,0.040766835,0.021315044,0.007219297,0.009474387,0.0074911686,-0.09344327,-0.0685076,-0.025048137,-0.042467035,0.11330756,0.009984182,-0.017554352,0.011077457,0.09627836,-0.036835432,-0.0066119507,0.00092780025,-3.8937078e-08,0.060323004,-0.039014634,0.027328141,-0.02919427,0.0035170722,0.006608662,0.010917697,0.011000341,0.029055817,-0.015364925,-0.009541784,0.030202013,-0.052717544,-0.05541285,0.007870844,0.065533824,-0.014209396,0.037628703,0.023310041,0.024911784,-0.09633628,-0.012940101,-0.0631233,0.023892507,-0.009348364,-0.12054071,0.00676267,-0.013330317,0.08343906,0.006785174,0.04406456,0.016956788,-0.05165722,-0.025975555,-0.04585477,0.0704913,-0.086487666,-0.089949004,-0.025562003,0.014706299,-0.061384577,-0.066972926,-0.075095564,-0.066470936,-0.0036277121,-0.014763953,0.034834847,0.05737481,-0.036378104,-0.054101963,-0.018463958,-2.9948322e-05,0.053854965,-0.088916086,-0.102622375,0.010931992,0.067713596,0.018198645,-0.024561595,-0.11552727,-0.02846665,0.036782466,0.20872699,-0.011557289 +1.14.14.89,"A cytochrome P-450 (heme-thiolate) protein. Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.14.90, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones.",384,1.0,-0.059378974,-0.027958998,-0.07465444,0.008970636,0.010702561,0.065559246,-0.03723899,0.07593572,0.008863215,-0.08520261,0.005586337,-0.001615743,-0.068113156,0.019812163,-0.051801722,0.03399055,-0.07671912,0.0037916512,-0.0050311247,-0.05760997,0.025122268,-0.019803802,0.046368495,0.011367695,-0.04874856,-0.023032874,0.020164073,0.10765574,-8.910885e-05,-0.0052875476,-0.029869724,-0.022054533,0.026707282,0.009938178,-0.015397956,0.119062625,-0.08406977,-0.020105772,0.026679514,-0.050582536,0.1416312,-0.0638248,-0.026241181,0.05245468,0.04726896,-0.06363761,-0.01186345,0.017496232,0.022163656,-0.022493137,-0.08060262,-0.011404766,-0.044033334,0.046047796,0.004336853,-0.04582026,0.046759754,0.00791416,0.0005800242,-0.05897618,-0.03160786,-0.0062749493,0.01882468,-0.0014438936,0.0048053665,-0.04057069,-0.04069547,-0.01316691,0.009346435,-0.0627033,-0.0022984333,-0.05545398,-0.03222269,0.03908911,-0.036572374,0.09315169,-0.11030376,0.0061288187,-0.058161203,-0.050366204,0.072837375,-0.007890101,0.012147468,0.13470449,0.02125621,-0.051924445,-0.07299745,-0.016013995,-0.04405121,-0.025399368,0.03239028,0.07271455,0.0013978239,0.03415855,-0.052243583,0.04066502,0.05347678,0.014253701,-0.045709882,0.015040018,0.0034470337,0.02982453,-0.12965298,-0.083087906,-0.020231567,0.001232733,-0.028194183,0.037452906,0.08619333,-0.042896982,-0.06591839,-0.071270116,-0.0029815806,-0.054135047,0.022803215,0.050240804,-0.004884733,0.006030357,0.058996484,-0.03978337,-0.04943693,0.020230308,0.045267068,0.011415838,-0.028731292,-0.023375517,-0.09882104,4.728195e-33,0.09861701,0.023159279,-0.030973554,0.052286614,0.019035472,-0.023549201,-0.034195684,-0.02385752,0.022415247,-0.0161959,-0.11348685,-0.032948636,-0.031590264,0.003081114,-0.04360849,-0.02710858,-0.05927961,0.04483541,0.070830286,0.0009216716,-0.030965587,0.01615934,-0.07225759,-0.002625899,-0.01034771,0.07782446,-0.085418575,-0.02563501,0.00022122294,0.017581917,-0.08173409,-0.0262464,-0.055206593,-0.06882642,0.0077972836,-0.01441262,-0.033819083,-0.043862265,-0.10717281,0.0050106766,-0.072199136,-0.058102936,-0.01103947,-0.10709742,0.08548115,0.0224483,-0.13377409,0.0732146,0.018416509,0.029393187,0.07264934,-0.06673018,0.1429345,0.031256393,-0.060382485,-0.009595888,0.013439101,0.018784959,0.042492438,0.071102925,0.11451394,0.030876188,-0.0031827195,0.044834528,-0.0039272364,0.07097866,-0.03132977,-0.007996086,-0.007654393,0.16721317,-0.021922052,0.04384916,0.011441041,0.00685542,0.061658364,-0.011725733,-0.034103617,0.023414632,0.015161281,0.051232,-0.014148279,-0.034015108,0.008345853,0.0024369687,-0.030161805,0.0072877714,0.012479974,-0.0073426296,0.02513625,0.010122854,0.03875899,-0.043337267,-0.009872312,0.040457014,0.0048537026,-5.568122e-33,0.026394475,-0.03031579,0.0056688874,-0.077851094,-0.053114112,0.0328738,-0.03932328,-0.025764061,0.00511767,0.053806886,0.113824,-0.101209134,-0.025173996,-0.012399535,-0.034400042,0.046644907,-0.022188716,0.044062063,-0.008627981,0.044033963,-0.05557115,0.000614853,-0.014797277,0.14803012,0.067821786,0.015950859,0.074711256,0.027482543,0.044331122,0.02628681,-0.049973756,0.050364047,-0.05558281,-0.0047580064,-0.031067763,0.09775668,-0.022790983,0.05445495,0.041203022,0.034006365,0.028248359,0.048551846,0.003623537,0.046611823,0.022910375,0.0731209,-0.019572368,-0.007361318,-0.023785181,-0.048724797,0.058576535,0.035003282,0.02206851,0.05706586,-0.006788801,0.056737855,-0.0031384882,0.00028073302,0.034552418,-0.06278145,-0.04980713,-0.080499806,-0.03291411,0.068301305,0.036920194,0.058037393,-0.019916708,0.01227622,0.019776741,0.030681472,0.07386124,-0.043849207,0.08372185,0.09779479,-0.0024490892,0.014306254,0.032360032,0.004934613,0.011097135,0.021213522,0.016465647,-0.003470963,-0.0018424939,-0.08939048,-0.079267375,-0.056206454,-0.036071073,0.09021698,0.007032233,0.0045756316,0.012174609,0.112110525,-0.034508795,-0.022676626,0.00582886,-4.6625342e-08,0.03807309,-0.039456256,0.046479337,0.0024379115,0.014881403,-0.010166931,-0.0008800698,0.017981159,0.030475935,-0.01786944,-0.017191015,0.039236955,-0.02380097,-0.05208717,0.005879059,0.042285953,-0.012571619,0.047608715,0.028228035,0.04540816,-0.08774358,0.009281692,-0.07823153,0.0096616605,-0.0215484,-0.11934734,0.004601655,0.0019408962,0.094764404,0.007473028,0.04815641,0.017421,-0.03418852,-0.013679539,-0.082811676,0.069273554,-0.049527414,-0.08315917,-0.031415675,0.023904769,-0.05483978,-0.07484297,-0.07245974,-0.06723084,0.030119337,-0.02297599,0.029669952,0.04456204,-0.017924843,-0.040024303,-0.019521749,0.0094095655,0.040346965,-0.085747965,-0.07511741,0.008180406,0.04725455,0.017295897,-0.023878422,-0.113416374,-0.017089222,0.02554727,0.22667386,-0.0066353553 +1.14.14.90,"A cytochrome P-450 (heme-thiolate) protein. Acts on daidzein, formononetin and genistein. EC 1.14.14.89, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone.",384,1.0,-0.07836896,-0.0015598421,-0.031602956,-0.032236025,0.042255517,0.06864465,-0.036716178,0.08708927,-0.020591706,-0.05346185,-0.03264495,-0.017131286,-0.052337207,0.069320075,-0.04360403,0.068213895,-0.052542057,0.008966862,-0.007895844,-0.066610955,0.020036886,-0.0018613745,0.075779304,0.0078070215,0.0150007745,-0.015199015,0.049426086,0.10726044,0.02008452,-0.030510688,-0.0036112892,0.023038708,-0.01718657,0.036638528,-0.026739584,0.09931294,-0.04844899,-0.049847893,-0.007862237,-0.07051725,0.12508203,-0.028443178,-0.06896701,0.042565018,0.034241162,-0.050795928,-0.07337784,0.029396532,0.027567288,0.0045578605,-0.06653594,-0.05849966,-0.019810127,0.051175155,0.03452858,-0.010099497,0.04694262,0.024691291,-0.0035757837,-0.039778538,-0.035113662,-0.0136440955,-0.015219667,-0.0018890988,0.02988489,-0.020693563,-0.03486085,-0.03562624,-0.0121571515,-0.06457913,-0.023072014,-0.056576543,-0.02583063,0.008553766,-0.07058517,0.041944053,-0.076879255,-0.0068570473,-0.020277437,-0.05404541,0.02303445,-0.0037023148,0.021591648,0.12079279,0.021577572,-0.044577576,-0.04560536,0.009443841,-0.027307535,-0.022867236,-0.05763173,0.041173093,-0.012865483,0.011213059,-0.07351284,0.074602075,0.020090437,0.016447129,0.009828268,0.02266959,0.028777884,0.049441695,-0.07141963,-0.12077716,-0.093099065,0.024670223,-0.014918907,0.04932209,0.07633989,-0.06321557,-0.02431752,-0.079179645,0.03595804,-0.013059006,-0.008385811,0.050429128,0.003403595,-0.0047155623,0.024858518,-0.08890116,-0.02390858,0.011430184,0.06936413,-0.0012983672,-0.0471427,0.017821182,-0.11737216,2.7480933e-33,0.12757152,-0.011962255,-0.04122028,0.057823144,0.00028494722,0.020049607,-0.05322841,0.07284001,-0.0372563,-0.039385807,-0.07763356,-0.032254003,0.0066262158,-0.015377708,-0.03196223,-0.060487516,-0.029659724,0.045074314,0.0418784,0.028180629,-0.014161097,0.05254421,-0.05220844,0.0060582333,0.029928645,0.056800418,-0.053865466,-0.008636409,0.011946248,-0.0034675787,-0.06624831,-0.049697362,-0.05056285,-0.019101163,-0.022518666,0.0010210833,-0.04438971,-0.032560755,-0.06458759,0.01485688,-0.020325134,-0.05013967,0.01861659,-0.12207833,0.071590245,-0.020790998,-0.13191502,0.049116783,0.011210304,0.046680383,0.05771786,-0.06574744,0.12425801,0.015829194,-0.043250617,0.011894976,0.00833696,0.043247025,0.060764834,0.066689424,0.1012676,0.051789485,-0.020694781,0.07144938,0.015830658,0.04603608,-0.015331916,-0.008274789,-0.05671371,0.13565545,0.0068068947,0.029755376,0.035105515,-0.014563025,0.06586825,-0.04712068,-0.0099923005,0.029608838,0.01828612,0.06050756,0.016965834,-0.015431688,-0.018318415,-0.017836409,-0.043488093,0.0154296085,0.023356996,-0.03196262,-0.040783957,0.059697293,0.02793671,-0.08604636,-0.010411277,0.0073757633,0.032444336,-3.2728973e-33,0.044072468,-0.03356072,0.01787001,-0.056045588,-0.03477674,0.05223666,0.04100169,-0.042914893,-0.023359938,-0.003371912,0.14821881,-0.10881613,-0.025556615,-0.014258983,-0.027900577,0.007837237,-0.024005877,0.013045843,-0.011728076,0.07082379,-0.0050288755,0.04865512,0.002280144,0.088413,0.077309184,0.010007257,0.08819769,0.01940202,0.022379277,0.054680437,-0.08797778,0.030901587,-0.06204984,-0.030152094,-0.022463582,0.07941412,0.015552847,-0.0004597449,-0.005992983,-0.0096767545,-0.0006149846,0.09965358,0.046887655,0.11341145,0.036607,0.10772498,-0.09112655,-0.027332189,-0.027402647,-0.009508248,0.019635513,0.034282405,-0.025999904,0.043796062,-0.037068106,0.013492216,0.014125596,-0.0017652942,0.009163203,-0.049048435,-0.025170824,-0.07087101,-0.019434378,0.10051076,0.059274152,0.110890605,-0.049252484,0.064012736,0.051699586,0.019538365,0.070529856,-0.038426615,0.0775791,0.09710793,0.0016053353,0.0071057235,0.010319654,0.021539785,0.04186506,0.0155410245,0.032842644,0.01874058,-0.052598566,-0.07742796,-0.04015854,-0.07270111,-0.06800986,0.09329708,-0.011222521,0.0035835435,-0.012571359,0.11602959,-0.083709635,-0.028051704,0.024479711,-4.556541e-08,0.010385505,-0.09080783,0.07793093,-0.025494983,0.07225977,-0.041079115,0.00032541645,0.014040257,0.06196263,-0.040797282,-0.025387328,0.07982787,-0.014316243,-0.040610988,0.0056663407,-0.01959614,-0.004203432,0.013529185,0.004060183,0.018772032,-0.045394577,0.022700302,-0.080559075,0.050766796,0.00014777177,-0.11358233,-0.05071047,0.02620359,0.08283774,-0.015228032,0.03405257,0.036918018,-0.03135042,-0.052425593,-0.022374656,0.027326813,-0.033338197,-0.04079274,-0.012899141,-0.02984432,-0.031046048,-0.0876733,-0.0117621375,-0.0387171,0.00073965907,-0.047895648,0.052399695,-0.026088312,0.0122849215,-0.020393277,0.0069611412,-0.015191877,0.045920826,-0.086375766,-0.11195278,-0.02448842,0.05682812,-0.04371869,-0.02544883,-0.10255535,0.01406077,-0.0047367522,0.20462427,0.017537076 +1.14.14.91,A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.,384,1.0,-0.08234073,0.0259588,-0.06698864,0.014283561,0.089494,0.12302507,-0.036512002,0.09336089,0.049121298,-0.009769703,0.03574111,-0.00452842,-0.06801147,-0.046777472,-0.05266616,0.008348449,-0.04220927,0.034534313,-0.0511176,-0.08737047,0.012781481,0.0415205,0.016334321,0.00026201518,0.013557142,-0.023881521,0.005595557,0.04364737,-0.019168632,-0.037107762,-0.03321165,0.0122500025,0.07801617,0.013192812,-0.03496546,0.097850636,-0.03642572,-0.11887528,0.032585125,-0.053841233,0.09351412,-0.0123866135,-0.048796512,0.020850407,0.016400719,-0.0022941115,-0.035206586,0.041506596,0.013925025,-0.02859431,-0.00892806,-0.013819398,-0.046237122,0.005682235,-0.043456562,-0.0140288435,0.073753975,0.018596621,-0.015080674,0.01683136,-0.0008127461,0.028317057,-0.0013529239,0.015539101,-0.007999601,-0.054901432,-0.06629535,0.037090063,0.02257058,-0.07128419,0.007735351,-0.06854425,-0.050480332,0.052421447,-0.09282788,0.084558226,-0.046018116,0.03920687,-0.017965736,0.00039347552,0.0719356,-0.0017808368,0.0015574838,0.1141564,0.038970646,-0.019677056,-0.07839661,0.07350625,-0.025057068,-0.007080302,0.010320338,0.043831896,-0.028415957,0.026584014,-0.09284694,0.07640247,0.07416469,-0.04407972,-0.01319875,-0.037353966,0.038111072,0.014602076,0.037789136,-0.07218347,-0.059355427,-0.0008099969,-0.05038899,0.00575418,0.049775064,-0.07453014,-0.044654217,-0.032076497,-0.01165513,-0.061385352,0.017053658,0.05373212,-0.024710128,-0.030997394,-0.01606265,-0.026449032,-0.057739496,0.026357047,0.03871107,0.053309064,-0.036501754,-0.01611073,-0.13619006,1.1595048e-33,0.09501387,0.016704535,-0.035331685,0.012869575,0.017574567,-0.027954636,0.0034404905,0.038311504,-0.022450564,-0.012350117,-0.11570497,-0.083434515,0.00971392,-0.07445022,0.013412994,-0.0046442808,-0.056201883,-0.020850848,0.05604937,-0.0054970914,-0.067422055,-0.022675222,-0.057456903,0.04477996,0.010974031,0.047144152,-0.01933821,-0.06504261,0.019304926,0.00090205035,-0.0548142,-0.072063215,-0.025838122,-0.04463591,0.013279355,-0.05006917,-0.027086485,-0.060154952,-0.095719315,0.040801458,-0.010623935,-0.03458099,0.036765777,-0.04602306,0.033247158,0.0050166044,-0.12217292,0.03380926,0.024563232,0.073901944,0.060321365,-0.05059085,0.14641498,0.09003029,-0.066626675,0.01800465,-0.022063695,0.05156089,0.009516976,0.07349424,0.0954665,0.0514935,-0.02518039,0.055633716,0.004936944,0.0657224,-0.06397693,-0.039055377,0.017442204,0.16255401,-0.0063276514,-0.07989886,0.07389803,-0.023736503,0.09649481,-0.017260706,-0.036882337,0.037392113,0.015949894,0.067600936,0.015897762,-0.027738689,-0.033019576,0.0016063337,-0.034306634,0.004051694,0.023240548,0.0035698684,-0.0024188,0.035695653,0.08470601,-0.054358203,0.023375697,0.036226213,-0.029577319,-1.3296641e-33,0.054955482,-0.051512755,0.034156255,-0.030871797,-0.034750108,0.032983694,-0.037930608,-0.08860978,-0.01593038,0.0118637625,0.0799119,-0.07405664,0.0076797,-0.003673224,-0.019520896,0.031776387,-0.023083368,0.058402155,-0.0029128955,0.094259866,-0.052375846,-0.04152203,0.049423043,0.017230313,0.031069756,0.0063202623,0.022769095,-0.035803456,0.0042031338,-0.0025164736,-0.038676605,0.041625813,-0.09188284,-0.03751405,-0.025222387,0.022430116,0.013083869,-0.013606599,0.0381943,0.07272876,-0.01767341,0.08501435,0.040045187,0.061282367,0.03565895,0.0810337,-0.061286017,-0.012601048,-0.03577812,-0.00306929,0.054498,0.030067062,-0.02114465,0.083802596,-0.026948212,-0.011184728,-0.005185641,0.07400402,-0.04855148,-0.0192013,-0.0038517772,-0.09522985,-0.012568585,0.06535078,0.033585917,0.08873787,-0.012713382,0.11798319,0.008189891,0.018928537,0.056750882,0.0008389254,0.074176356,0.12394548,-0.0022859673,0.016090916,0.011556765,-0.00892685,-0.0016157866,0.012645853,0.021743422,0.03575852,-0.049333192,-0.07671549,-0.04136241,-0.09462063,-0.07159512,0.101847894,0.07412655,0.0022029937,-0.037487656,0.056019805,-0.037303925,0.02991567,0.06346639,-2.7060292e-08,-0.027113797,-0.094046436,0.009761529,-0.012089039,0.06333643,-0.0028424251,0.01554824,0.0038755266,0.016785994,-0.000555252,-0.036171786,0.03873118,-0.05357048,-0.010961715,0.025024645,-0.022681136,0.052553773,0.060667567,0.04890267,0.050683655,-0.028123125,0.05007651,-0.08065196,0.012765691,0.0368978,-0.08867636,-0.035304137,-0.017871417,0.08858166,0.0070410203,0.042067047,0.049479388,-0.02263854,-0.029282259,-0.021746019,0.037158072,-0.027142078,-0.063422136,-0.042571194,-0.008817545,-0.05273128,-0.024438966,-0.044774707,-0.04308596,8.026977e-05,-0.021525623,0.05565044,0.060506962,-0.014322881,-0.03128828,-0.029705212,0.017864455,0.016876098,-0.105313875,-0.09865988,-0.034537263,0.08363812,-0.05100204,-0.022086767,-0.12243776,-0.049182154,0.016120998,0.1940964,-0.016868208 +1.14.14.92,A cytochrome P-450 (heme-thiolate) protein found in Aspergillus fungi.,384,1.0,-0.057986703,0.0589169,-0.08376717,-0.028882392,0.08511412,0.022099154,-0.050384674,0.10614127,-0.014038242,-0.039156042,0.0661115,-0.051884066,-0.03671867,0.05211442,-0.06608588,-0.029378852,0.050245307,0.004260877,0.0151839955,-0.08455393,-0.0014942925,0.11074185,0.04075244,0.03864309,0.008776634,-0.006090093,0.04094918,0.07172989,-0.0722195,-0.073453166,-0.10310697,-0.00034171552,0.030254634,-0.0490132,0.021848517,0.09719578,-0.08806669,-0.018246582,0.053144567,-0.042210195,0.038800493,-0.053345896,-0.05772119,0.010084886,-0.08454252,-0.0046581295,-0.025683,0.032752093,0.077542014,-0.037045047,-0.006759886,0.0044337693,0.0135088535,0.016473597,0.011359957,0.01912571,0.032481898,-0.05537852,-0.057179723,-0.019033432,-0.05277616,0.023385337,-0.035136353,-0.0010177066,-0.033114735,0.0012549339,0.015615228,-0.016189832,-0.05651025,-0.049451828,-0.014550568,-0.04419526,0.0011555481,0.02314561,-0.021072159,0.11554547,-0.030678151,-0.03416823,0.0057002017,0.0075466568,0.06366738,0.04134453,0.019779814,0.06294147,0.019850133,-0.03936265,-0.012082088,0.068064466,-0.06305522,-0.04328535,0.031282123,0.100583404,-0.0067631593,0.0059623485,-0.08271285,0.07964903,0.053998273,0.09969431,0.011080859,-0.055002857,0.062340487,0.018600319,0.040931012,-0.03235475,-0.009657083,-0.027963368,0.027160754,0.08467237,0.10856188,-0.07749519,-0.012490933,-0.04800695,0.015908543,-0.09857911,0.047745705,0.00511928,-0.00095268834,0.021140564,-0.03420548,-0.024404045,-0.035263564,0.039176878,-0.029893639,-0.052428465,0.015115307,0.015732737,-0.09149766,-5.6356413e-34,0.06463949,0.063983254,-0.05768255,0.02010026,0.00090968714,-0.020014565,-0.027465127,0.032376893,0.00030211505,-0.013515086,-0.0824895,-0.056670345,-0.092094414,-0.011589179,-0.041116927,0.013553245,0.0008539377,0.0038972567,-0.0015087192,0.038956035,-0.0124025345,-0.0013424794,-0.04402786,-0.0036590057,0.041808542,0.091832645,-0.007089166,-0.04342182,-0.008810648,-0.021018658,-0.031037305,-0.052882526,-0.09086826,-0.039962627,0.07844353,-0.034745734,0.035829443,0.02293381,-0.10224956,-0.03408485,-0.036551308,-0.002474378,-6.372606e-05,-0.11073139,0.023293147,-0.030266052,-0.11859628,0.026925996,-0.0029046768,0.02598979,0.10158457,-0.030572377,0.08854343,0.0890162,-0.030424412,-0.011614406,0.0059653744,0.05178202,-0.0040889615,0.05597535,0.08027398,0.060459122,-0.03785254,0.087952346,0.040382143,0.019846542,-0.06846722,-0.020722786,0.0023626005,0.088481106,-0.012167509,0.03154905,0.012590928,-0.047637947,0.013025432,-0.04557522,-0.061050255,0.024713337,0.034619246,0.042963594,0.05753685,-0.038460698,0.0069603357,-0.027491381,-0.08370237,0.018174281,0.10975214,0.017493522,-0.008367977,0.021454187,0.011742931,-0.077799596,0.0055441796,0.022095233,-0.013444178,-1.0526401e-33,0.13588664,-0.067567244,0.04913404,-0.045143295,-0.08245681,0.11031564,0.015227471,0.018175896,-0.042429656,-0.03925942,0.11708763,-0.0061267037,0.0017966699,0.034794908,0.009711289,0.019486487,-0.04794777,0.08077634,0.03271758,0.03581338,-0.04096425,-0.00037170085,0.011870442,0.048112925,0.07076557,0.025624268,0.028174218,-0.008044179,-0.010501026,-0.00063754147,-0.03706853,0.113798395,-0.034521066,-0.03243274,-0.06595304,0.049262553,0.04024484,-0.014365945,0.02049383,0.06127305,-0.029207636,0.022907265,0.0070433468,0.054199025,0.007847466,0.08286113,-0.017855402,-0.010631913,-0.011781985,-0.052533627,0.05078977,0.011952769,-0.04075011,-0.016919449,-0.05499561,-0.011036079,-0.008355421,0.007586066,0.020652,-0.0495954,-0.07554868,-0.004413236,-0.060932033,0.08902479,0.013895114,0.06654065,-0.057454824,-0.03873617,0.07950917,-0.008397957,0.007113704,0.027560264,0.051187366,0.06969295,0.036850058,0.0012597941,0.040543932,0.04372736,0.054735377,0.049837016,0.006443866,-0.022132281,-0.012444948,-0.042304106,-0.04911384,-0.12663426,-0.0073969937,0.07458323,-0.07274133,-0.049594875,-0.02469749,0.0829617,-0.0326368,0.05333418,0.07265499,-2.2175252e-08,0.047463737,0.015793167,0.01354457,-0.0884255,0.026785355,0.0029353232,0.08410089,-0.005803045,0.07916182,0.0055108997,-0.036479346,0.03168034,-0.0585,0.026832407,0.030158974,0.0017202507,-0.02221923,-0.008448615,0.058657825,0.03224839,-0.013074193,-0.011398875,-0.07348621,0.004445541,0.017101506,-0.06371709,0.034059938,-0.024347357,0.06855612,0.035004824,-0.016107822,0.034647577,-0.05983877,-0.04305025,0.07701262,0.015201222,-0.07199689,-0.083435945,-0.015495602,-5.0428403e-05,-0.03169102,-0.07376006,-0.10553273,-0.076680616,-0.0522139,-0.060881816,0.04300195,0.07486986,-0.03687592,-0.045092765,-0.01951664,-0.0015907969,0.012391751,-0.098945916,-0.082147755,-0.00746674,0.14003071,-0.029209442,-0.09722369,-0.11591142,-0.0002663457,-0.039959412,0.12050926,-0.030177727 +1.14.14.93,A cytochrome P-450 (heme-thiolate) protein found in soybean. The product of the reaction is the biosynthetic precursor of the glyceollin phytoalexins.,384,0.99999994,-0.080905154,-0.0089472085,-0.06329966,-0.016057756,0.085030966,0.1068743,-0.021318564,0.10770023,0.050529394,-0.03814384,0.08292175,0.028962266,-0.022967517,-0.06729247,-0.031494055,0.00020204342,0.00125237,0.055332374,-0.02404543,-0.10739241,-0.0018166606,0.07448845,0.0037074892,-0.015425651,0.013716221,-0.033618856,0.045623872,-0.030509554,0.006091474,-0.027767517,-0.016448425,-0.04839258,0.058352113,0.0062997937,-0.033811945,0.13052137,-0.042463586,-0.11858521,0.051297504,-0.093090974,0.06504356,-0.02411301,-0.036069993,-0.04754359,0.0109041575,-0.0063845823,0.014151154,0.0001802084,0.07197157,-0.07428354,0.009300924,-0.067346536,-0.0059495494,0.00088577997,0.013925215,-0.009927883,-0.0069656516,-0.0051617892,0.006603284,0.04732772,-0.081098124,0.0688166,0.05677578,-0.0022076797,0.012671947,-0.053816274,-0.0048373304,-0.0063354527,-0.01724162,-0.035600897,0.009523852,-0.036535203,-0.020110384,0.012837245,-0.08759418,0.10141085,-0.059347674,0.060973056,0.027139897,0.015896808,0.02583303,-0.060541466,0.055879477,0.13047893,-0.0013985395,0.008864549,-0.051241204,0.06928346,-0.061575267,-0.022170933,0.01651338,0.02945353,-0.029552327,0.060790107,-0.030679893,0.04591367,0.043369275,-0.010786692,0.03834044,-0.017013486,-0.0037088867,0.034226134,-0.012837291,-0.094333366,-0.07862377,0.054765366,-0.040372923,0.023772482,0.070512354,-0.022523846,-0.038303252,0.0039229672,-0.026846675,-0.007715328,-0.038147073,0.05346149,0.032475017,-0.0014285098,-0.01686357,-0.06742019,0.043375213,0.03732304,0.050394557,-0.0057856473,-0.07223406,-0.009042752,-0.066926144,1.9762051e-33,0.08482416,0.008113122,0.007485227,-0.011060728,-0.005214253,-0.010745631,-0.07969763,-0.024096685,0.037354574,-0.05993465,-0.070596494,-0.068061076,-0.026032912,0.03573103,-0.02089069,-0.004806003,-0.09304036,-0.033657975,0.10765718,0.004494976,-0.09273758,-0.04194584,-0.0114370175,0.017754594,-0.0006285731,0.06696161,-0.0077030323,-0.041252036,-0.0054889275,0.0091651995,-0.049647223,-0.08102847,-0.068447575,-0.025692536,0.012419231,-0.032110553,0.024903702,-0.049080476,-0.10928783,0.07007086,-0.006688967,-0.054645095,0.01508448,-0.07065659,0.055243313,0.046696264,-0.05462336,0.045696873,0.03719906,0.041717518,-0.012487042,-0.05258975,0.08394646,-0.020799525,-0.006803338,-0.0064563025,0.03774363,0.06397968,-0.0077119316,0.09943851,0.045817796,0.11923714,0.0064511625,0.048202317,0.024005236,0.09154889,-0.04414199,-0.013710562,0.011344826,0.09883378,-0.009604415,-0.0123250475,0.09015261,-0.0004878342,0.04479302,-0.08403537,-0.0037015746,0.05515421,0.0059179096,0.022469852,0.08288995,-0.012504538,-0.018747302,0.00048121033,-0.026279302,0.07250729,-0.039234098,-0.040442124,-0.0030266729,0.058075257,0.05636663,-0.017917408,-0.02523001,0.011658102,-0.109166175,-1.7767694e-33,0.05714663,-0.04430975,0.04265767,0.017363327,-0.019984372,-0.00078486296,0.012272505,-0.0021330242,0.019947916,-0.0041494477,0.053388167,-0.10845305,-0.008095719,-0.011100244,-0.01955459,0.059484906,-0.049112476,0.033974364,-0.04844127,0.010266716,-0.030109894,-0.0365271,0.049500275,0.019119335,0.083364405,0.051222935,0.002416969,0.048240416,-0.015773881,-0.024432778,-0.014610978,-0.0038905365,-0.07448876,-0.023677388,-0.02304671,0.0016201377,0.001615856,-0.0021089432,0.060327224,0.008501075,-0.008071002,0.07786809,0.03490544,0.012586138,-0.017667502,0.069257736,-0.07818281,-0.025854865,-0.012912634,-0.04955662,0.023355715,0.07681928,0.0028375783,0.04583109,-0.025718853,0.007980823,0.008857898,0.057092063,0.0237795,0.00815495,0.017613113,-0.08428681,0.0010043789,0.0850477,0.06411708,0.06339647,-0.034427244,0.059874974,0.030766752,0.04928889,0.051089898,-0.05361584,0.080102,0.050668523,0.013169902,0.032309588,-0.0064442717,-0.017405452,0.0376575,0.030302709,0.03765611,0.045654092,-0.08050778,-0.079417534,0.03192572,-0.028519806,-0.084580444,0.16883905,0.07938389,-0.01545866,-0.047216877,0.05119882,-0.09398959,0.041443367,0.070145756,-3.0376228e-08,-0.0040355464,-0.09742852,-0.0048482944,-0.043884095,0.074382626,0.04197007,-0.012802325,0.014376043,0.00645413,-0.033370566,-0.040818635,0.06690005,-0.0916263,-0.008786316,-0.053065535,-0.0047330726,-0.018314993,0.074370444,0.046046287,-0.0035803067,-0.036031164,0.022505356,-0.105605535,-6.458971e-05,0.011666644,-0.08120329,-0.040241007,0.03936669,0.054839294,-0.010211597,-0.019505356,0.041683953,-0.054871317,-0.093484715,-0.0041406993,0.014340626,-0.109221935,-0.035048295,-0.045173682,-0.018685045,-0.053728387,0.009911448,-0.004387814,-0.02451671,-0.019969687,-0.027160646,0.052129686,0.091001675,-0.04139522,0.0047560516,-0.01327327,-0.045626424,0.01691507,-0.07829754,-0.10826906,-0.038644973,0.061827358,-0.06435967,-0.05245193,-0.11441299,-0.064845085,-0.01584419,0.19496469,0.037321556 +1.14.14.94,A cytochrome P-450 (heme-thiolate) protein found in mammals.,384,1.0,-0.08122965,0.042111438,-0.012459035,-0.015411675,0.04574467,0.054823164,0.016780451,0.09824649,-0.018678157,0.032128453,-0.01344813,-0.010982505,-0.04872182,0.06102976,0.013028958,-0.018576387,-0.025720716,-0.03215382,0.050736267,-0.08718422,-0.03473182,0.06324672,0.019470865,0.017156456,-0.037808437,-0.0089581525,0.05815224,0.07761046,-0.035923705,-0.012477216,-0.07926316,-0.051529165,0.040150244,-0.01307328,0.020821512,0.06379948,-0.07911608,-0.059641212,0.008456268,-0.07084085,0.10673748,-0.015411316,-0.07308003,0.06495759,-0.018571852,-0.01862512,-0.020092918,0.00089671183,0.04259894,0.02561732,0.014275486,-0.015846614,-0.050428454,0.047169678,-0.04987707,-0.027479181,0.030147549,-0.015068523,0.008300574,-0.04916788,-0.06701771,0.048495162,-0.0029673325,0.008276315,0.04370863,-0.034426283,-0.01304254,-0.008537307,-0.040764797,-0.06012568,0.007180034,-0.055576406,-0.0073732375,0.046764642,-0.10793705,0.059603084,-0.0070850346,-0.005270867,-0.008643568,0.010162296,0.035778258,0.026252769,-0.0036262786,0.11259074,0.060698207,-0.013912648,-0.042460438,0.0544419,-0.11039593,-0.07323347,-0.012263029,0.036090177,-0.0509146,-0.04078809,-0.08695198,0.036407735,0.010520211,0.041747693,0.0059804814,-0.025599727,0.052172787,0.042664226,0.02913557,-0.08661545,-0.03207376,0.026547216,-0.0100603355,0.067563795,0.09195946,-0.09715642,-0.0574397,-0.008368294,0.0046454137,-0.013146552,0.06627497,0.04724381,-0.043499466,-0.011737141,0.01512979,-0.03044682,-0.052445147,0.025547713,0.0346315,0.008580258,-0.016574828,-0.02424497,-0.08155491,-2.0877413e-33,0.079645336,-0.0071875714,0.014120617,0.042209115,-0.034923162,0.033216234,-0.042284478,0.05831531,-0.030128349,0.01850085,-0.056382753,-0.08664245,0.029127473,-0.048951052,-0.042715672,-0.015944077,-0.048821412,0.038217556,0.04587049,-0.02355305,-0.077607065,-0.0036081376,0.020619845,-0.022042897,0.013675383,0.08946395,-0.07339328,-0.04442179,0.020759815,0.009000778,-0.08200267,-0.051545985,-0.033974163,-0.038089916,-0.020095503,-0.048330203,0.015920691,-0.026438462,-0.061101913,0.024005,0.009157282,-0.065672204,0.030512495,-0.08843799,0.0414892,-0.027499977,-0.12832142,0.0016153144,-0.053375635,-0.006998585,0.051132046,-0.09208279,0.08666826,0.05897853,-0.09686707,-0.008568565,0.01975116,0.028263284,-0.02033637,0.0681078,0.15685588,0.07733633,-0.047743198,0.059443213,0.053246673,0.04178784,-0.049253855,-0.043181524,-0.032684293,0.15244178,-0.0018049265,-0.001879466,0.07971323,-0.089924134,0.028284581,-0.01973458,-0.0007661082,0.12527254,0.06349121,0.06198574,0.029835917,-0.030196672,-0.03610992,0.0064505893,0.014043711,-0.0020124572,0.12356261,0.00038743054,0.019773526,0.041599818,0.060975835,-0.092789456,-0.017729625,-0.020279536,-0.030758485,3.2789265e-34,0.057125516,-0.04474878,0.031044329,-0.07475831,-0.05548645,0.06698274,0.0299832,-0.012400581,-0.043428376,-0.004736252,0.12988138,-0.05840665,-0.006256368,-0.037453506,0.045975227,0.00890988,-0.056679256,0.009817667,0.022059228,0.034438074,-0.017813463,-0.07496798,0.018522989,0.030758237,0.056808457,0.020208878,0.004521405,-0.023429748,0.061448604,-0.009832427,-0.0811819,0.095873296,-0.075672634,-0.064081125,0.0003088281,-0.0046883943,0.029485218,-0.010390875,0.004790031,0.01859605,-0.05357966,0.102439396,0.028930472,0.07147923,0.031132624,0.12496743,-0.03339407,-0.053437002,-0.051187623,0.0062223114,0.065011896,-0.01861676,-0.05340967,0.005023386,-0.07082856,0.010268481,-0.032247405,0.030659325,0.014624051,-0.0423342,-0.03152075,-0.0095233815,-0.048242413,0.07247628,-0.002323376,0.04739427,-0.03517627,0.034502417,0.0052715563,0.020554489,0.0064022597,-0.005972499,0.07114555,0.06621988,0.02798246,0.038740344,0.05557208,0.010487123,0.0908203,0.033122815,-0.015841803,0.027911473,-0.097717516,-0.022140613,-0.0019846545,-0.07593185,-0.10030033,0.120132506,0.074179985,-0.0421274,-0.067063004,0.064794555,-0.056998216,0.041706167,0.025586437,-2.3020194e-08,-0.020476032,-0.057684533,-0.007887497,-0.013641562,0.04156694,0.05035894,0.029386155,0.0012070446,0.03192517,-0.01640675,0.03744852,-0.0007077201,-0.040141717,-0.009270157,-0.010658738,0.026984954,0.00383503,-0.0032639357,0.07978576,0.058394212,-0.027803292,0.010883163,-0.013962036,0.027287832,0.040831495,-0.07601666,-0.015919026,-0.009283822,0.03660707,-0.009708959,-0.0089238435,0.030604273,-0.048882592,-0.014327098,0.115093194,0.039920118,-0.03387479,-0.031015333,-0.047684744,-0.0036358335,-0.012045744,-0.026134366,-0.06623264,-0.059333913,0.025454497,-0.029334348,0.050973553,0.058683753,-0.044589803,-0.08171736,-0.103635,0.010705032,-0.00043567916,-0.08264152,-0.0851279,-0.034710415,0.07036276,-0.100010045,-0.042918563,-0.11081115,0.043542072,0.021798246,0.14289524,0.006544291 +1.14.14.95,A cytochrome P-450 (heme-thiolate) protein. This plant enzyme catalyses three steps in a pathway that leads to the biosynthesis of many sesquiterpenoid lactones.,384,0.99999994,-0.036867447,-0.007097444,-0.014438973,-0.004287851,0.03435107,0.098684944,-0.054522477,0.11711221,0.024159841,-0.0136976335,0.026214065,-0.031894628,-0.05008126,-0.062417522,-0.013271665,0.03569134,-0.08129911,0.069157995,-0.010282445,-0.07612037,0.03590024,0.0410789,0.009041525,0.053173997,0.06279913,-0.019660115,0.016081069,0.0457147,0.008987169,-0.06888255,-0.06503405,-0.037944786,0.04461586,-0.009381606,0.015846202,0.071877375,-0.017886158,-0.083802275,0.0507434,-0.019069217,0.10361408,-0.04221523,-0.031283986,0.015699865,-0.062333897,-0.022917807,0.013018887,0.034645706,-0.01150492,-0.043483675,-0.021861186,-0.047128975,-0.07900582,-0.0008876855,-0.03398956,0.007772229,0.061395098,-0.005529676,0.020634308,-0.011634962,0.02053847,0.027430559,-0.010943878,0.008746996,0.021747964,-0.045232162,-0.012120635,-0.015430313,0.008561443,-0.030107606,-0.03699509,-0.10672963,-0.04427134,0.02214367,-0.09267552,0.1015761,-0.02988463,-0.0036448229,-0.0011024169,-0.021080326,0.052661907,-0.018920952,-0.006632412,0.13313168,0.0602104,-0.03411097,0.009543421,0.043688428,0.008373347,0.009552268,-0.017316341,0.018548567,-0.043710526,-0.007981201,-0.113408856,0.102202766,0.057586428,-0.030016696,-0.0077460473,-0.026190039,0.057272512,0.08900431,0.016173901,-0.0950358,-0.052452564,0.028403983,-0.044742074,0.003254275,0.04874351,-0.08304925,-0.03762978,-0.04948876,-0.00895529,0.008096674,-0.029002318,0.14359432,0.008145156,-0.038178753,0.03733775,0.018411828,-0.027140597,0.024678111,0.0048905355,0.036350965,-0.052479673,-0.02023455,-0.08676501,1.9278769e-33,0.09593402,0.07266797,0.01803994,0.031248715,-0.010818465,-0.021313932,-0.07450448,0.057143364,-0.084590875,-0.0070837988,-0.06266372,-0.11494173,0.03787604,-0.02203634,-0.0045539187,-0.030388905,-0.0547106,0.024917634,0.052991655,-0.01843498,-0.08251233,-0.028304888,-0.06489743,0.0053318175,0.042100534,0.060842674,0.008942748,0.00040936875,0.025225407,0.005783011,-0.007341192,-0.05105237,-0.08081445,-0.038969688,0.04582444,-0.06095205,0.024226518,-0.019511864,-0.092020586,0.053771894,-0.06250123,-0.016081518,-0.007582305,-0.07912487,0.03938044,-0.019521276,-0.085761495,0.0024469492,0.04132957,0.04223499,0.054256625,-0.07148485,0.110328846,0.09449992,-0.051953454,-0.023794645,-0.06378119,0.032545224,0.0070758522,0.06187307,0.120981485,0.00091700966,-0.049560055,0.04541643,0.07238959,0.09869916,-0.07769195,-0.05584197,0.0002721664,0.099166445,-0.07294101,-0.039259955,0.02972818,-0.06538322,0.04043223,0.022048188,-0.055961296,0.043244317,0.005132964,0.06636261,-0.022805475,-0.0348753,-0.043423824,-0.05885569,-0.012864675,-0.02432229,0.023921963,-0.017931553,-0.005039913,0.012409228,0.06802529,-0.07643969,0.019889658,0.00960832,-0.046859503,-2.249736e-33,0.04548814,-0.07895328,0.038979664,-0.069159396,-0.04386643,0.014775462,0.001751965,-0.045206457,-0.00042973965,0.026534868,0.07599632,-0.06977241,0.060444567,-0.026342683,-0.009623949,-0.010382508,0.014792341,0.05388121,0.028318364,0.09316848,0.038684368,0.052758276,0.009817802,0.08200197,0.025661174,0.050651465,-0.02454063,-0.01479274,0.007631763,0.06327555,-0.013077222,0.027797405,-0.048654318,-0.002154926,-0.076014325,0.08777798,-0.0010647821,0.034697197,0.05189983,0.08218049,-0.047930535,0.07998386,0.03102036,0.06197717,0.0669796,0.044271316,-0.07437759,0.035038844,-0.0057209353,-0.038933758,0.073261,0.018534506,-0.01766274,0.041272763,-0.01395179,0.019659624,-0.016727388,0.0032201936,-0.005285092,-0.03585784,-0.04273349,-0.017617838,-0.0152824465,-0.005984186,0.021013806,0.06351188,-0.08615756,0.021716472,0.017529681,0.019444698,0.02976461,0.06861888,0.039718095,0.08549199,0.015445407,0.0070837345,0.0135203125,-0.09246228,-0.032047734,-0.01790453,-0.01546949,-0.004576054,-0.017494764,-0.037898637,-0.04785202,-0.08188278,-0.059281275,0.121269725,0.081573136,-0.014229007,-0.047716215,0.018702729,-0.031781256,0.14959688,0.0911463,-3.061705e-08,0.0041553644,-0.06596182,0.0035940192,0.015046276,0.028313737,-0.007534124,0.014225635,-0.0048136907,0.09587585,-0.04577438,-0.02945383,0.07608961,-0.006936186,0.011109261,0.04847765,-0.011745775,0.037369713,0.021879558,0.01580141,0.00898531,0.012022647,-0.026132269,-0.047790676,0.037810735,0.082665175,-0.120842665,-0.024263231,-0.00084746315,0.02474787,-0.0057571973,0.090992056,0.042132847,-0.030675631,0.008212619,-0.0014710731,0.047242418,-0.06152735,-0.07889401,0.0093058,-0.02162927,-0.0074430136,-0.07194,-0.1016985,-0.041609168,-0.024144657,0.011552536,0.02659473,0.017063383,-0.02487635,0.0037135847,-0.056501217,-0.031994507,0.0007715424,-0.05075842,-0.045765754,-0.040061194,0.06788279,-0.016648494,-0.035498943,-0.1011685,-0.0041940813,0.011460849,0.21408883,-0.06983821 +1.14.14.96,"A cytochrome P-450 (heme-thiolate) protein, found in plants. It also acts on trans-5-O-(4-coumaroyl)shikimate.",384,1.0,-0.05725546,0.020913115,-0.03277403,-0.005783683,0.05666503,0.108926594,-0.0008712091,0.068926476,0.066259794,0.027066229,0.07034927,-0.0105830245,-0.04865989,0.006399256,-0.044247035,0.05117222,-0.04621612,0.03679052,-0.0187672,-0.09630195,-0.0044043455,0.049446415,0.011171486,0.017294617,-0.017862674,-0.03114961,-0.0066670035,0.03947587,-0.0073089832,-0.07412829,-0.06421415,0.038813908,0.009206256,0.021174373,-0.026553195,0.09823998,-0.038696047,-0.12174942,0.024157345,-0.024997346,0.075283125,-0.009777321,-0.049469937,0.0042260373,-0.027648523,0.011820637,-0.023034798,0.009852992,0.069054216,-0.07553646,-0.021567939,-0.039649643,-0.03900431,0.007060595,-0.01855321,-0.030105954,0.03432731,-0.0145043265,-0.008939438,0.015718259,-0.00076913665,0.053872667,0.007292751,-0.00027496458,-0.00053516566,-0.028200319,-0.068907246,0.027304798,0.026241496,-0.059541013,0.005416474,-0.10273987,-0.0186989,0.056182407,-0.10398298,0.05738567,-0.048508234,-0.0065191197,0.022865847,-0.018016867,0.009162993,0.045566995,0.023836453,0.10391711,0.05488231,-0.017569311,-0.033402447,0.07583113,-0.029227916,-0.042357355,-0.0077593224,0.016060555,-0.034869287,-0.018938785,-0.08622776,0.04006759,0.0794828,-0.041419744,0.011870529,-0.052526202,0.06268483,0.06974538,0.022473939,-0.085756026,-0.08958522,0.0057144654,-0.046419773,0.0642769,0.048188116,-0.085881405,-0.060142305,-0.043907896,-0.0436253,-0.071399406,-0.0060508116,0.08034693,-0.013173808,-0.025382746,-0.026686206,-0.013895594,-0.067985095,0.011790977,0.015802894,0.052592847,-0.039899435,0.023687849,-0.12043469,-2.0262233e-33,0.10890404,0.036243916,0.012485386,0.06141345,-0.04420885,-0.017110236,-0.029399017,-0.002651131,-0.040179454,-0.05269538,-0.0586526,-0.04973379,0.024538042,-0.026170228,-0.005749202,-0.025555799,-0.06560851,-0.006088452,0.06408323,0.021997066,-0.065477364,0.023664568,-0.039276686,-0.020079512,-0.0017365199,0.07347873,-0.0083165895,-0.09777146,0.024147756,0.0026727095,-0.04021805,-0.044935104,-0.04175474,-0.028901996,0.04738911,-0.03931392,-0.0066782064,-0.022766165,-0.084058985,0.07435373,0.048373926,-0.066145405,0.037854657,-0.046298176,0.07715684,-0.02849826,-0.14653808,0.015896302,-0.017107628,0.07066129,0.04939244,-0.02721935,0.10174081,0.042370375,-0.10403126,-0.0423671,-0.007444694,0.035050493,0.009048087,0.08363733,0.091269694,0.048955727,-0.06708109,0.050154988,0.052211016,0.046286326,-0.06281477,-0.048636172,-0.029917127,0.16064155,-0.039371107,-0.05667696,0.08064403,0.023632795,0.09380014,0.0012991326,-0.020347515,0.06680836,0.008567069,0.080539845,0.018216794,-0.0635449,-0.02603196,-0.025668144,-0.036087625,0.0013648007,0.06003348,-0.022290958,-0.041258752,0.038775217,0.07703976,-0.039633926,0.007736112,0.025193267,-0.04519639,4.173306e-34,0.07593753,-0.0792163,0.024646226,-0.0337824,-0.059741944,0.05148467,-0.010667185,-0.057552975,-0.008779281,0.04080565,0.1395849,-0.05034003,0.014921841,-0.01625861,-0.0022015597,0.0068484303,-0.033821143,0.04523007,-0.0173281,0.08774516,-0.042132013,-0.023383267,0.0501923,0.057324227,0.05675551,0.071032435,0.021625565,-0.052691657,0.006102682,-0.018276189,-0.018007893,0.004636798,-0.054719307,-0.047472037,-0.04532505,0.003457641,0.006902333,-0.025965607,0.005073119,0.041149117,-0.031193035,0.07880987,0.076472215,0.07710882,0.043518078,0.07228834,-0.09073494,0.010910823,-0.01933809,0.0019072248,0.06631819,0.0018203903,-0.0055717225,0.029802699,-0.025672013,-0.006368024,-0.030004073,0.060915153,-0.014099315,0.014672692,-0.018964604,-0.047524642,-0.018342802,0.07936873,0.0009324147,0.0830003,-0.0011922453,0.032714043,-0.008327989,-0.0035030092,0.010995608,0.024733037,0.07549788,0.07406561,0.00030078393,0.02354203,0.039944652,-0.015569211,0.015765883,0.023238614,-0.024514066,-0.0041930256,-0.0443105,-0.07661191,0.008546336,-0.086726926,-0.081055775,0.11562533,0.07688105,-0.021270012,-0.045522667,0.060640518,-0.07430901,0.010886401,0.07137533,-3.2531446e-08,0.021878563,-0.097186126,-0.0049685575,-0.044732448,0.048182566,0.008359619,0.016682638,-0.024282172,0.05800057,0.00045478056,0.0150836855,0.054158647,-0.05050156,-0.024186129,0.0377014,-0.0156007735,0.049455855,0.036035318,0.057593033,0.016582303,-0.064937845,0.008295549,-0.026830206,0.026098462,0.021831531,-0.09145947,0.02152907,0.007962221,0.06768327,-0.02645963,0.044466257,0.054179188,-0.03683784,-0.016334375,0.038123734,0.04714437,-0.025127392,-0.056735773,-0.0773276,0.04185417,-0.017513664,-0.0045221495,-0.076844856,-0.05831764,0.0018914482,-0.017734196,0.050746016,0.025844242,-0.020620817,-0.018405685,-0.023210378,0.015323208,0.031150876,-0.10409697,-0.14084667,-0.021248128,0.08170054,-0.109364584,-0.02238733,-0.12798963,-0.023900328,-0.01154278,0.16404606,0.04599522 +1.14.14.97,"A cytochrome P-450 (heme-thiolate) protein involved in the biosynthesis of isoquinoline alkaloids in plants. It also hydroxylates (S)-cis-N-methyltetrahydrothalifendine, and (S)-cis-N-methyltetrahydropalmatine.",384,1.0,-0.07224078,0.021297473,-0.02411782,-0.031058382,0.008197128,0.10482117,-0.026191365,0.07855381,0.047035825,-0.046064265,0.048431795,-0.030308906,0.000819832,-0.06341623,-0.026315484,0.06644225,-0.06759589,0.06728311,-0.016115995,-0.10232439,-0.052009888,0.0730966,0.0047529535,0.056388028,0.026222957,-0.010368349,-0.034992814,0.080298446,-0.021293877,0.008518319,-0.016087765,-0.00544698,0.0054379003,-0.05003054,-0.042624656,0.09690634,-0.05040874,-0.04687263,0.06865367,0.0396574,0.074707136,-0.04744666,-0.09823759,0.06847366,-0.051142998,-0.015677266,-0.004897011,0.057066362,0.015574141,-0.018539643,-0.018477874,-0.027143274,-0.08254349,0.069053344,-0.016634913,-0.026290879,0.055265304,0.08990257,-0.048664637,-0.004126091,0.018063568,0.041423015,-0.012221254,0.0060643386,-0.012711716,-0.0005780333,-0.0468813,-0.009296127,0.06500391,-0.06456522,-0.0303619,-0.12817998,-0.052759144,0.029815808,-0.092039704,0.11474987,-0.08177427,-0.01195948,-0.031932037,-0.058519945,0.037187845,0.0147469975,-0.0032932302,0.075181134,-0.0052890293,-0.026812417,-0.0150482915,0.042640653,0.012145637,-0.007902094,0.019093284,0.0046042446,-0.037413467,-0.02521797,-0.10916462,0.06820068,0.06467798,-0.016274804,-0.023945,-0.03325681,0.062941864,0.04832908,-0.08685914,-0.08562306,-0.059263024,0.016872857,-0.0695983,-0.041024324,-0.016241457,-0.071646586,-0.051335614,-0.0331604,-0.005854073,-0.017088125,0.005667243,0.085478075,0.033194024,-0.021085188,-0.04143854,-0.03757065,-0.10684859,0.005011067,0.05248906,0.016573614,-0.03379943,-0.0014306372,-0.04444746,1.660303e-33,0.08618735,0.053305935,-0.00037524832,0.021836998,0.0012920001,-0.026396621,-0.060109086,0.025178924,-0.060041975,-0.03794266,-0.08417133,-0.060098253,-0.00852804,-0.019886779,0.011815472,0.00989731,-0.047628216,0.027184995,0.066383556,-0.0267375,-0.0997329,0.01741851,-0.0707518,-0.005246882,-0.031107394,0.08876344,0.023770336,0.007366748,-0.027189516,-0.013624221,-0.06522781,-0.080429845,-0.024812575,-0.078154214,0.038701173,-0.025387267,0.0019135905,-0.0032783344,-0.03570822,0.061040394,-0.017904684,0.021496916,0.059960514,-0.04273394,0.032638285,0.048522536,-0.108714476,0.053206727,0.021090772,0.0560796,0.042436674,-0.028646842,0.13394523,0.043361735,-0.07047575,0.0017181947,0.013082452,0.015271316,-0.030782344,0.04189144,0.036436595,0.024312692,0.005674999,0.045638144,0.04204433,0.017339014,-0.07402981,-0.021836432,0.007994461,0.111879036,-0.058287594,-0.023079518,0.06448082,-0.007921566,0.08153533,0.0018154426,-0.038760066,0.027886083,0.0020967117,0.0471797,-0.043381784,-0.009310755,0.017398216,-0.05111925,-0.007854153,-0.012088618,0.03603349,0.01988637,-0.028811222,0.037560675,0.07503775,0.010017189,-0.016542485,0.013097529,0.00011607506,-2.5652216e-33,0.047143187,-0.102266416,0.015987618,-0.073190056,-0.03106807,0.022882441,-0.049747385,-0.016866917,-0.007991239,0.044938494,0.09750176,-0.01352338,0.0075356,0.020644777,-0.03620053,-0.08695333,0.002147999,0.117943116,0.007596473,0.08405002,-0.028348777,-0.008437469,-0.03693664,0.07883481,-0.00072119356,0.021057352,0.013363396,-0.008066264,0.060321346,0.03434076,0.032910038,0.017661512,-0.06692593,-0.00086820964,0.0075764367,0.03897061,0.030358622,0.05521284,-0.0011271661,0.02343269,-0.0036345776,0.05537447,-0.0041036867,0.017123738,0.054513115,0.049201667,-0.050170448,-0.00051835773,-0.07678967,-0.009629883,0.09132574,0.018900089,0.013689981,0.06417722,0.02166138,0.009021982,-0.0495336,0.035028752,0.0506652,-0.035298098,-0.004842438,-0.04317607,-0.03129236,0.020430228,-0.022595506,0.09276137,-0.03920686,0.01889648,0.014791778,-0.010653884,0.070509166,0.005391258,0.04728094,0.10505664,-0.020644976,-0.0062348074,0.057595856,-0.052380964,0.0012275669,0.017270565,0.011607667,-0.0028594716,-0.018785827,-0.06970857,-0.057959206,-0.025833607,-0.07550479,0.13367869,0.044031743,0.0028290919,-0.00770196,0.05191532,-0.078256294,0.049298696,0.08754376,-3.7899387e-08,0.004081484,-0.079856314,0.053578608,0.007411356,-0.0070105307,0.0003011378,0.029543674,-0.011509225,0.06588961,-0.018043121,0.02068794,0.037990436,-0.033701275,0.033692878,0.02974335,-0.011386013,0.09073205,0.07087771,0.0284157,0.024475483,-0.07357385,0.033680357,-0.02654083,-0.060593355,0.05652038,-0.13139558,0.031395912,0.009694792,0.09514888,0.0015867276,0.08458747,7.4521064e-05,-0.038904455,-0.046920016,-0.004847108,0.04335791,-0.03540227,-0.055078413,0.034348417,-0.014839697,-0.06007164,-0.054022413,-0.09188292,-0.008138675,0.035209853,-0.036647625,0.039610777,0.032306958,-0.0027672497,-0.023482557,-0.03978422,-0.012209798,0.086178765,-0.16806373,-0.102697946,0.013551835,0.043229323,-0.049522765,-0.05650937,-0.14166465,-0.017516172,-0.025497904,0.20105775,-0.025196284 +1.14.14.98,A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants.,384,0.99999994,-0.058496736,0.03392543,-0.021820758,-0.05726724,0.01593157,0.12460561,-0.038754046,0.06487784,0.04159116,0.009752937,0.02324143,-0.04460055,0.00027384504,-0.054266285,-0.07025762,0.027310848,-0.08031305,0.011571387,-0.069907695,-0.07945426,-0.06993467,0.08911145,0.030443596,-0.009151102,0.022196088,-0.017193396,-0.005235713,0.073151104,-0.021272093,0.013787427,-0.02262506,0.02081814,-0.011544076,0.00039956026,-0.01668757,0.03959314,-0.08143723,-0.07871868,0.08952256,0.05015054,0.044380333,0.034497295,-0.13874885,0.029795514,-0.069572024,-0.010415974,0.013373732,0.0118531175,0.012896996,-0.042832077,0.033860102,0.008803579,-0.0056142723,0.038917635,-0.071165636,-0.050366063,0.022324758,0.109273426,-0.062342696,0.023392934,-0.0054012937,0.058601465,0.005161887,-0.021614512,-0.013755029,-0.008052645,-0.046926375,-0.014814409,0.01070153,-0.054928113,-0.05004287,-0.09242935,-0.0031719983,0.032125268,-0.0634373,0.048515078,-0.03760132,0.011244737,-0.041049253,-0.047628894,0.044638615,0.009639323,-0.06726218,0.12014482,-0.0014374307,0.033232305,-0.02126716,0.08969856,0.002580709,-0.024313493,0.07324656,-0.012435511,-0.035078123,-0.041915424,-0.11896767,0.11998253,0.048304588,-0.03848162,-0.044686895,-0.028285915,0.037693426,0.017228369,-0.03549038,-0.08376072,-0.053704556,0.03197162,-0.01578687,-0.00877494,-0.046597224,-0.08800585,0.018358963,-0.022126414,0.0016776182,-0.019476447,0.0007136726,0.08976036,-0.00888492,-0.08189375,-0.044033814,-0.03431634,-0.057871543,-0.026479142,0.027434595,0.059619367,-0.03132345,0.011541929,-0.08364588,7.2278714e-34,0.06714721,0.049615707,0.004865846,0.013720974,0.04357674,-0.043464944,-0.056207113,0.057075214,-0.024711309,-0.012301732,-0.09262301,-0.07381274,0.04326419,-0.07404864,0.02604255,0.023874404,-0.074671626,0.04356012,0.04069775,-0.03517133,-0.051546615,-0.03098361,-0.020510746,-0.015871054,-0.023043416,0.13796352,0.013961967,-0.035153806,0.014328424,-0.038518075,-0.06810614,-0.03500539,-0.025476541,-0.031711362,-0.003838661,-0.011569893,-0.0064933817,-0.0039841733,-0.023707537,0.038026113,0.021269975,0.019786526,0.058114838,-0.012318134,0.032455605,0.052644737,-0.13784121,-0.006115876,-0.006811914,0.046530012,0.0030865523,-0.05729508,0.1381239,0.10954753,-0.06479948,0.052612506,0.0067130835,0.017101133,0.012325808,0.04871811,0.021874031,0.046437223,-0.03375541,0.05045553,0.04365384,0.04731106,-0.06921204,-0.023422688,0.009384132,0.14196594,-0.012846084,-0.0647896,0.053152207,0.035248492,0.06068129,-0.002673926,-0.019729022,0.084892616,0.023968795,0.08126006,0.038234007,-0.08510706,-0.030863453,0.00924164,-0.023045594,-0.0148395905,0.076785676,-0.019238628,0.0066185733,0.080899335,0.06558957,-0.018263204,0.03317363,-0.02829191,-0.050831713,-1.3319268e-33,0.085392065,-0.027759142,-0.0024420011,-0.07727008,-0.024651954,0.019763594,-0.07723594,-0.044457182,-0.057144716,0.028523972,0.081284516,-0.018453076,-0.008370026,0.02150177,-0.05794945,-0.089506425,0.03646001,0.102284804,0.019417748,0.066394486,-0.046502497,-0.06291706,-0.002827646,0.026758717,0.015550967,-0.010013422,0.04861801,0.022305101,0.018056536,-0.007616744,0.022737581,0.03721128,-0.0657194,-0.02927872,0.015016078,0.06535568,0.0066063944,0.006373257,0.031739093,0.09283396,-0.0368828,0.00566511,0.022097167,0.04541378,0.040900357,0.042144004,-0.087271966,-0.0478687,-0.06634877,-0.035321973,0.08908801,0.043270066,0.0065771183,0.022990867,0.027000928,0.022111941,0.014108768,-0.031814788,0.015697986,-0.03334846,-0.0032751148,-0.014809669,-0.040103063,0.036562886,-0.050595056,0.05635467,-0.03464156,0.05494755,0.015121817,0.015645908,-0.0138389785,-0.03826497,0.10762855,0.09709316,-0.06309583,-0.013323807,0.068583585,-0.027453447,0.07417592,-0.04154355,-0.0015552688,0.031019181,-0.02918204,-0.040560894,-0.045990285,-0.040860865,-0.0804488,0.12914756,0.060379546,-0.05790704,0.0147505095,0.059189912,-0.02692612,0.062737495,0.063207656,-2.529476e-08,-0.014112602,-0.082801074,-0.0011142523,0.028603498,0.010173384,-0.01697206,0.033856355,-0.005639293,0.040654223,-0.04532265,-0.00070071686,0.030431807,-0.05711579,0.06278337,-0.0019531639,-0.012844135,-0.006058197,0.03168312,0.054011654,0.09609347,-0.06951099,0.054927703,-0.07717852,-0.049148377,0.06298001,-0.07886897,-0.005435763,-0.020527514,0.07066574,0.0031192733,0.08349703,0.018899752,-0.005701017,0.031455617,0.07476388,-0.009069328,-0.060655937,-0.02852398,-0.015956653,-0.045749433,-0.01783882,0.002136456,-0.08976055,-0.0226959,0.037001453,-0.04098165,0.035257146,0.037223093,0.03991272,-0.013794154,0.0028304528,0.014232778,0.0653879,-0.17498347,-0.08445928,-0.043164045,0.016124839,-0.039347142,-0.024410179,-0.09769477,0.016180057,-0.005070561,0.11453908,0.0441838 +1.14.14.99,A cytochrome P-450 (heme-thiolate) protein from peppermint (Mentha 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+1.14.14.100,A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher 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+1.14.14.101,A cytochrome P-450 (heme-thiolate) protein from the plant Thalictrum bulgaricum.,384,1.0,-0.08008965,0.022468586,-0.026928207,-0.019851452,0.007011386,0.12146492,-0.050611,0.07404342,0.030057712,-0.017730841,0.020525606,-0.050579537,-0.036505222,-0.06837053,0.0046298713,-0.0013732234,-0.060428984,0.0107674,-0.014020911,-0.078810915,0.002833125,0.06918388,-0.0045335176,0.023385137,0.019095859,0.014701618,-0.0028009824,0.031275317,-0.020924712,-0.041804522,-0.06769968,0.00109031,0.06747172,-0.04929843,0.008132289,0.0626097,-0.072072715,-0.099158995,0.037126254,-0.042266715,0.11292702,0.01483765,-0.06964864,0.06184135,-0.06872127,-0.017696457,0.03162474,0.05722314,0.023176288,-0.01029274,-0.002852556,-0.009443843,-0.068510145,0.05352471,-0.070739396,0.032771125,0.061050206,0.057562288,0.038489792,0.007985283,-0.028230418,0.059807763,0.013098019,-0.02668307,0.014077814,-0.032982066,-0.062414534,0.0116521465,0.0008010973,-0.040975846,0.024108721,-0.06389055,-0.0033349597,0.044965975,-0.08826827,0.04549307,-0.03562396,0.022428337,-0.0028684738,0.029255604,0.07164949,0.045293756,0.0077001266,0.11147627,0.012701419,-0.034545302,-0.035902902,0.08161714,-0.03440957,-0.043316297,0.06157347,0.029725136,-0.037751265,-0.023670662,-0.11005309,0.106208555,0.035503414,-0.03946057,0.016420873,-0.050380547,0.048635878,0.043082617,0.04187005,-0.068115056,-0.043301,0.01591146,-0.06154437,0.006160612,0.068300255,-0.09407619,-0.030051952,-0.05084643,0.0025254495,-0.03143021,-0.0081487335,0.03683686,-0.04203349,-0.051455222,-0.01862098,-0.021132313,-0.03373242,0.023927487,0.019532785,0.019918047,-0.026676955,-0.03494022,-0.15771684,9.700172e-34,0.07142669,0.007168544,-0.03608747,0.029830959,-0.021487927,-0.04190702,-0.038737938,0.08147936,-0.047226727,0.015763113,-0.038030803,-0.10490052,0.00061642576,-0.08905181,-0.06125608,0.024153419,-0.08061977,0.022787897,0.011005616,0.025856776,-0.064473346,0.022948302,-0.015614948,0.014659342,-0.0088927355,0.101223096,-0.010502094,-0.04452502,0.09348506,-0.026869494,0.013514016,-0.09159485,-0.0443307,-0.04957132,0.057373717,-0.03525491,-0.011377774,-0.025902163,-0.11373211,0.04414056,-0.018340314,0.0013794631,0.016120499,-0.07098506,0.07144688,-0.036737606,-0.12631947,0.020205023,0.024266357,0.034023643,0.07676524,-0.053119145,0.103288494,0.06138603,-0.057171807,-0.0065199127,0.02236446,0.10003024,0.012845226,0.050188985,0.0982481,0.027578475,-0.022738041,0.056509335,0.050503682,0.07043755,-0.11861898,-0.019906271,0.0004978787,0.10771026,-0.010678768,-0.020626273,0.056831144,-0.06991313,0.04329346,0.017497133,-0.016119797,0.08112326,0.0018209659,0.06643861,0.014079877,-0.028182937,-0.014616953,-0.029615259,-0.022505624,-0.03303298,0.07226362,0.039029963,-0.0035655075,0.06917375,0.08683528,-0.07881289,-0.011327434,0.013612349,-0.021093568,-8.858724e-34,0.07887336,-0.054535992,0.047811955,-0.067974485,-0.027905669,0.08091673,-0.027043562,0.00826431,-0.041220915,0.041606117,0.1299251,0.010084819,-0.00672112,-0.005499013,0.02819442,0.002109185,0.04310218,0.022888057,-0.032699782,0.057031,-0.08180372,-0.022723803,-0.007382165,0.009134997,-0.0038368308,0.044458684,0.013123114,-0.03341655,0.057120014,-0.014269353,-0.0011887696,0.041550107,-0.10458097,-0.05587293,-0.022302132,0.015355188,0.0037670054,-0.014662827,0.008345126,0.040743496,-0.019810716,0.062785216,0.017361004,0.069378294,0.04050698,0.030189231,-0.06146137,-0.072041966,-0.053174432,0.048533805,0.09360787,-0.022407621,-0.031573735,0.03561582,-0.06611904,-0.049200952,-0.051865716,0.05042866,-0.007858754,-0.03312831,1.5394096e-05,-0.06057981,-0.03728045,0.0579727,-0.000592004,0.07164834,-0.05099949,0.04465525,-0.010970073,0.01973162,0.031134298,0.02915681,0.061233237,0.088431224,0.012045802,0.044126596,0.037492197,-0.04182805,0.013747344,0.016339505,-0.0046661557,-0.00012672423,-0.068152115,-0.045886934,0.04526239,-0.090455465,-0.07872757,0.123276524,0.06851205,-0.046210352,-0.03582083,-0.009404865,-0.01781914,0.067372136,0.10505334,-2.5474337e-08,-0.03801621,-0.08239324,-0.05223599,-0.0064737573,0.046586104,-0.015764598,-0.016375057,-0.0030822277,-0.004965003,0.0106957955,0.022697506,-0.0021236052,-0.0723764,-0.01893179,0.017250713,0.0053504375,0.03344726,-0.0031302946,0.076543495,0.048120268,0.003050052,0.029162614,-0.04617257,0.04517589,0.029908327,-0.086751446,0.06153726,-0.022085806,0.04230045,-0.004862824,0.06496268,0.050846424,-0.00047525877,0.025431287,0.05798221,-0.007295734,-0.013690298,-0.024939671,-0.04112284,0.009399085,0.020349484,-0.019076593,-0.09980695,-0.07097278,-0.02245471,-0.041227046,0.0512534,0.07819683,-0.017244406,-0.038960386,-0.06477847,-0.006193406,-0.008713584,-0.099315815,-0.09645836,-0.025274863,0.109994456,-0.023326566,-0.06675872,-0.05308025,-0.003832794,0.0017366298,0.16990007,-0.0026167247 +1.14.14.102,A cytochrome P-450 (heme-thiolate) protein involved in benzylisoquinoline alkaloid synthesis in higher plants.,384,1.0,-0.070353955,0.02796247,0.011880255,-0.047246207,0.006673942,0.11916337,-0.07533823,0.07371917,0.030803304,-0.017091675,0.03415314,-0.0387559,-0.0038165757,-0.062692024,-0.024981532,0.051828064,-0.073499165,0.047061604,-0.04510975,-0.08503574,-0.075987644,0.07660246,0.004707117,0.02804002,0.05061189,-0.01462058,-0.037595678,0.07493255,-0.041117508,-0.0051610568,-0.015133527,-0.0014654341,0.025200892,-0.020526176,-0.05144131,0.050964214,-0.0902153,-0.067496374,0.07422711,0.027680345,0.062017605,-0.00069164706,-0.11899843,0.052224077,-0.05693995,0.00026851692,0.013508668,0.03276415,0.028926186,-0.021580605,-0.010419133,-0.0073942905,-0.042435106,0.04432636,-0.06264114,-0.0098046055,0.08186609,0.13669738,-0.035058245,0.021633029,-0.014229547,0.054582726,-0.019406786,-0.0073628807,-0.026733948,0.0165897,-0.08095716,0.0010010228,0.040098034,-0.051854774,-0.017744731,-0.093561254,-0.024124695,0.012204147,-0.081764705,0.10301019,-0.049736757,0.017882664,-0.052002914,-0.044971794,0.049567346,0.004678095,-0.03813835,0.08454349,-0.038252003,-0.0015704128,-0.014164586,0.0651864,0.013593068,-0.013380522,0.05907166,0.02385278,-0.06540463,-0.017315615,-0.092990994,0.1189414,0.076155946,-0.011719065,-0.034329314,-0.04458051,0.09045501,0.02091977,-0.035835054,-0.068767056,-0.030210787,0.0338625,-0.024761925,-0.050533157,-0.03457285,-0.099003494,0.014253553,-0.035510153,0.010876021,-0.047362644,0.009629553,0.051705506,0.0006496222,-0.034969978,-0.06544101,0.001410584,-0.07440706,-0.012954062,0.028946234,0.0024515616,-0.03972464,-0.01348986,-0.06261466,1.2656731e-33,0.09450543,0.04557978,-0.030452518,0.042585816,0.01954371,-0.04346797,-0.07269071,0.042805225,-0.078506954,-0.020518644,-0.0853005,-0.053798303,-0.005830027,-0.06290959,-0.0006680268,0.033368208,-0.060911387,0.01763517,0.047829628,-0.025463957,-0.086723804,-0.03427249,-0.05654248,0.0016457731,-0.044329964,0.122465365,0.017233903,-0.02236741,-0.052062113,-0.03273969,-0.061370477,-0.05827136,-0.04592013,-0.046381447,0.0070630875,-0.009357156,0.0072782994,-0.0030724541,-0.044222705,0.041155916,0.01637963,0.04878647,0.06368469,-0.0034887227,0.040021308,0.03983873,-0.13251106,0.034869768,-0.007169244,0.06196914,0.014102935,-0.059767004,0.12442859,0.08969854,-0.04922901,0.0072524296,0.028969876,0.055915598,-0.019246284,0.04327697,0.055885725,0.044255495,-0.025168914,0.06731452,0.03156838,0.022069108,-0.04944248,-0.00474095,0.034335997,0.122820765,-0.018229593,-0.05451963,0.05181819,0.010167361,0.057311364,-0.024542337,-0.021547994,0.032444526,0.04286375,0.07671332,0.004462541,-0.06588646,-0.015536382,-0.031081062,-0.0325582,0.004937722,0.026216099,0.016504051,-0.013607824,0.06965421,0.06325438,0.008185351,0.04641637,0.0035569805,-0.021405896,-1.7200551e-33,0.06534581,-0.060760014,0.018046804,-0.058716,-0.045635935,0.024565518,-0.08720546,-0.028731516,-0.030482523,0.045117524,0.07867644,-0.019342879,0.019785423,0.032554355,-0.034411106,-0.086205214,0.01710059,0.10171151,0.02032402,0.07142314,-0.044871412,-0.033496004,-0.024220932,0.052621882,0.00524129,0.013997392,0.017850721,-0.00905612,0.032295678,0.017912848,0.03223454,0.029668925,-0.061782446,0.0081845075,0.01935819,0.054510713,0.032749362,0.012668129,0.023362888,0.07815352,-0.035559382,0.039978825,0.039103936,-0.0016439727,0.047732223,0.03810645,-0.05833899,-0.030045502,-0.08592732,-0.0035310765,0.09956885,0.019603545,-0.023264881,0.050389435,-0.012070443,0.0023290736,-0.0070574745,-0.006977942,0.032739382,-0.052887723,0.007685215,-0.04671847,-0.041515816,0.03072498,-0.068362065,0.10960572,-0.009561531,0.07039563,0.0051304004,0.0027889276,0.017449997,-0.016736642,0.09136615,0.09672892,-0.029905748,0.030948933,0.084939495,-0.03253703,0.039231613,-0.0398358,0.012629553,0.030081753,-0.01744769,-0.06939142,-0.030610893,-0.049744185,-0.109795295,0.12170653,0.052045748,-0.013565971,-0.0037600778,0.05511788,-0.0272147,0.037641216,0.08200243,-2.5815936e-08,-0.011796424,-0.052025586,0.0063245455,0.027559362,0.028956443,-0.008866757,0.014921475,0.0020545085,0.06807888,-0.008517682,-0.0015822755,0.013528464,-0.06248799,0.052457456,0.040751893,-0.022911789,0.046453618,0.043427195,0.0462816,0.09036055,-0.05761995,0.06383316,-0.037964348,-0.049252935,0.06835439,-0.11473326,-0.0049270997,-0.00025611496,0.059838075,0.017510204,0.08259953,0.028437626,-0.03810592,0.0023606995,0.053981777,0.00620771,-0.024028618,-0.05571895,-0.01092217,-0.033735376,-0.051210996,-0.061597325,-0.09884893,-0.043418948,0.012612521,-0.079002224,0.03682611,0.029816652,0.011811703,-0.020858012,-0.018769285,-0.0054665743,0.09918033,-0.15588363,-0.09395318,-0.013253036,0.05878523,-0.026507894,-0.03778217,-0.13826023,-0.0009711803,-0.01890563,0.12304581,-0.035089716 +1.14.14.103,A cytochrome P-450 (heme-thiolate) protein from the plant Madagascar periwinkle (Catharanthus roseus).,384,1.0,-0.063474976,0.05469629,-0.091822945,-0.05293412,0.055986628,0.07978169,-0.003369731,0.059208896,0.037943922,0.022834167,0.014998413,-0.0029256844,-0.04668074,-0.019855745,-0.056948252,0.041944616,-0.03133616,0.007892184,-0.0062043704,-0.034220826,0.016538562,0.08135878,0.022977006,0.017229289,-0.0033741002,0.018318431,-0.053099375,0.07225775,-0.021646949,-0.04071068,-0.020349745,0.013672135,0.031021303,-0.013758164,-0.018186912,0.07456991,-0.06630668,-0.10102361,0.022673296,-0.010101923,0.10003953,-0.0030194325,-0.08370501,0.0053014737,-0.038065877,0.0024580306,0.036983516,0.03289517,0.050177176,-0.0784525,-0.019580213,-0.060521618,-0.05137792,-0.025527593,-0.075221024,-0.07165831,0.049633987,0.013278091,-0.0449329,-0.02904167,-0.03956804,0.05781875,0.011203632,0.029695712,0.014571784,-0.055531282,-0.08298799,0.039001048,0.028059695,-0.08796905,0.030156914,-0.05818705,-0.015317382,-0.0023247662,-0.112829655,0.11764813,-0.024191335,0.03901946,-0.019963132,0.01683092,0.0005048607,0.011319409,0.025739241,0.15814327,0.05676347,0.0063832686,-0.031463455,0.06640891,-0.067500025,-0.07502527,0.03796739,0.021333406,-0.002045084,0.04597892,-0.0966301,0.05535117,0.007458289,-0.054589935,-0.0069458364,-0.027106004,0.032118488,0.017984897,0.02264688,-0.09073985,-0.06958527,0.0033550847,-0.018005691,0.0498536,0.08647644,-0.073125295,-0.0657974,-0.04559106,-0.010601306,-0.024505593,0.015475836,0.025546245,-0.024616808,0.025195677,0.00719484,-0.024168687,-0.0844219,-0.02143723,-0.0055074994,-0.012307981,-0.008247087,0.020660657,-0.12438182,1.2289685e-33,0.09765209,0.047481924,0.00013833544,-0.0166513,-0.0026102394,-0.008860255,-0.09617579,0.021419613,-0.015095078,0.024564868,-0.10336953,-0.06673075,-0.014533327,-0.068843305,-0.02736815,-0.0020102977,-0.018545311,-0.009165637,0.062598705,0.03089628,-0.01296723,0.023378745,-0.03281452,-0.05202887,0.012275369,0.07885583,-0.010275298,-0.075589806,0.0018768462,0.001631809,0.0035371373,-0.10178376,-0.05708781,-0.06941077,0.011040065,-0.091818765,-0.029221,-0.024157774,-0.069106944,0.07977848,0.0026095624,-0.051740438,0.0215397,-0.05563686,0.10013733,-0.0075280257,-0.09783191,0.09734566,0.017812083,0.043466605,0.028792487,-0.051957108,0.134547,0.06927133,-0.12510419,-0.0003218268,0.032437313,0.07307077,0.040912442,0.091540016,0.078633994,0.046607167,-0.025072426,0.016058922,0.075717084,0.034453962,-0.022077726,-0.009832234,0.024109045,0.094181575,-0.035258558,-0.024951465,0.05601982,-0.04021519,0.08208393,-0.02544572,0.0006129736,0.084691904,0.09285574,0.059101943,0.01703081,-0.025981907,-0.034564983,-0.035184257,-0.029023638,0.022477703,0.078622125,0.024782633,-0.015553916,0.05266224,0.08785769,-0.07165719,-0.0003398976,-0.029248847,-0.00077941903,-1.03902405e-33,0.022878593,-0.055314615,-0.0016762714,-0.061527077,-0.0003964095,0.055830874,-0.013899689,0.004129809,-0.007400599,0.020450803,0.06602736,-0.027785355,0.026630607,0.005725494,-0.036773752,0.0014713806,-0.025319157,0.07293744,0.0041913292,0.012258026,-0.07349611,-0.0060686683,0.02884219,0.020249054,0.01865366,0.02342486,0.05269406,-0.027406204,0.043524772,-0.014263454,0.01652996,0.0806042,-0.06105487,-0.06084047,-0.073079295,0.010667595,-0.015404894,-0.008887976,0.058259446,0.056081906,0.0122157335,0.08963742,0.035138853,0.032591555,0.055879705,0.047235537,-0.10018964,-0.018332636,-0.051886342,0.009548517,0.06651474,-0.0021012246,0.034100194,-0.00025780257,0.021151971,-0.019211395,-0.026308458,0.042652864,-0.012970208,-0.034723397,-0.01169665,-0.071927525,-0.013024304,0.093599476,-0.039084475,0.085877016,-0.0058634346,0.030565558,0.02633461,0.04188343,-0.004141644,-0.009348258,0.060189083,0.06459319,0.022131214,0.055638954,0.029422833,-0.01381682,0.059396103,-0.0104030585,-0.040924475,-0.011079375,-0.054867126,-0.09533249,-0.0034338995,-0.036360443,-0.045809373,0.08759164,0.041543793,-0.042552233,-0.004226477,0.08836939,-0.028130913,0.012151816,0.08684351,-2.7797022e-08,0.047100987,-0.08036236,0.01750901,0.019532178,0.045471992,-0.019647896,0.03546116,0.009208981,0.024230106,0.014149204,0.058678064,0.028566277,-0.03923937,-0.07187754,0.03083249,0.028579852,0.12263794,0.0023122835,0.05414962,0.049710806,-0.024843771,0.07203528,-0.038690247,-0.028486038,0.046477117,-0.113602735,0.035552118,-0.026351452,0.040533327,-0.00065929745,0.042421035,0.03871967,-0.04630157,-0.07345302,0.028315391,0.036463045,-0.023239259,-0.08417447,0.0037824155,-0.06590149,-0.014363039,-0.061045308,0.009119608,-0.06052357,-0.01809244,-0.017683528,0.064288445,0.07684468,-0.05640509,-0.09548738,-0.033550832,0.0012921889,0.017768977,-0.12625581,-0.12446478,0.014441745,0.048806965,-0.056817193,-0.042926375,-0.090926096,-0.014356307,-0.017010586,0.118630975,-0.015252571 +1.14.14.104,A cytochrome P-450 (heme-thiolate) protein from the plant Rauvolfia serpentina. Forms a stage in the biosynthesis of the indole alkaloid ajmaline.,384,0.99999994,-0.06440232,0.03969198,-0.064653486,0.011862553,-0.020404508,0.09733062,-0.05264963,0.018682892,0.014536104,-0.011091201,0.019487735,-0.04505899,0.011548999,-0.047487292,-0.06254242,0.06618645,0.00046118142,0.06784405,-0.057270627,-0.075434834,0.015863376,0.066129655,0.02512728,-0.03194631,0.054539222,0.020064618,-0.041283414,0.021840287,-0.0018336896,-0.043232556,-0.007625442,-0.0060450463,0.024197627,-0.0345189,0.0014682859,0.0334352,-0.097561486,-0.040664427,0.0855643,0.026859123,0.050302327,0.014331265,-0.1122294,0.04095193,-0.075114794,-0.045640998,0.010869159,-0.011851814,0.06689506,-0.058906764,-0.0008540696,0.023098545,-0.06975696,0.0041812747,-0.07530869,-0.08917904,0.02725895,0.03152633,-0.023316007,0.02139526,0.041546952,0.076405555,-0.032329936,0.042833276,-0.03845458,-0.094580546,-0.05226629,0.013273895,0.0712985,-0.05452505,-0.0045197727,-0.055195756,9.4912684e-05,0.0151439775,-0.0649087,0.10354225,0.021302728,0.0052456274,-0.05444023,-0.040039998,0.024202088,0.036444012,0.042440884,0.07481352,0.0351008,0.018924616,0.010531701,0.089253,-0.018046591,-0.0068999054,0.06571191,0.018536674,-0.008270878,-0.06485616,-0.018680802,0.0757855,0.06929561,-0.023604274,-0.018646907,-0.011620216,0.057231817,0.007898794,0.0047420207,-0.02267466,-0.027776515,-0.020231266,-0.06646705,-0.009348788,0.017182471,-0.042048097,-0.0073272027,-0.08174687,-0.008953508,0.018366264,0.014849246,0.07742429,-0.033477154,-0.020247167,-0.009088797,-0.05612486,-0.050618213,-0.020000817,-0.007956353,0.04172865,-0.008552595,-0.007877107,-0.12874103,2.2785395e-33,0.07667855,0.030821452,-0.04866254,-0.0037903048,0.0060438258,-0.04506415,-0.094996214,0.0340164,-0.025312182,0.022939134,-0.106511004,-0.03283155,0.040137894,-0.046771266,-0.047585517,0.0030075759,-0.0752243,-0.009107243,0.04471157,-0.059956018,-0.07722103,0.012545418,-0.045936603,0.033824548,-0.07103761,0.07186798,-0.0001704107,-0.060722977,-0.013054057,0.0013803301,-0.034393206,-0.0742879,-0.05572688,-0.0037905106,-0.03970803,-0.032667637,0.012766674,-0.045518477,-0.08804143,0.03718314,-0.0024041457,0.056539297,0.052716527,0.03546918,0.05128271,0.026633512,-0.11876794,0.05432244,0.024822889,0.06048827,-0.025591435,-0.012863182,0.18334407,0.03610184,-0.08569582,0.02752275,0.0051645334,0.034228325,0.0051386785,0.07021796,0.017675327,0.0077046966,-0.040386576,0.08881453,0.034581456,0.044257194,-0.04661517,-0.09347464,0.06071766,0.09752283,-0.06298136,0.023408042,0.06640721,0.011655152,0.07718416,0.019103816,0.051485,0.036732618,-0.03793567,0.06627462,0.02079808,-0.0031404975,0.0034846654,-0.029925846,0.06405536,-0.011108166,0.025264814,-0.039504822,0.032536987,0.073620364,0.05666755,-0.015866145,-0.070917726,0.05088252,-0.01714289,-1.7836169e-33,0.073564105,-0.05554228,0.01360817,-0.058991343,-0.05762454,0.048379354,-0.052851424,0.052508343,-0.03666255,0.025137369,0.09782879,-0.030212758,0.07748706,0.030559594,-0.015263088,-0.100809924,0.04472658,0.0742971,0.0038383834,0.11494635,-0.09275197,0.044023544,-0.027257953,-0.02483278,0.059268065,-0.022516137,0.013082124,0.0026519613,-0.032102093,0.010260735,0.03502206,0.033670727,-0.07953241,-0.03965473,0.0024767835,0.0323008,0.0018405498,0.02005899,0.010233519,0.13183919,0.007624091,0.0814391,0.0052126045,0.028520556,0.061768252,0.04523949,-0.029442498,0.047875553,-0.03318081,-0.08346944,0.051939305,-0.034730386,0.03296371,0.005386853,0.0416162,0.015432654,0.018084044,0.031802975,0.0012472809,-0.0032531344,0.01687953,-0.04789747,0.02349804,-0.02003882,-0.0303263,0.14292362,0.014488115,0.05900077,0.025072178,0.008746628,0.034504876,-0.011762781,0.05301389,0.09072801,0.042599827,-0.025208374,0.018627468,-0.04572609,-0.011930515,-0.01107757,0.025486184,0.06550513,-0.018581415,-0.12157676,0.043726005,-0.005209453,-0.04664004,0.15045308,0.044572476,-0.056982514,0.023385882,0.03666738,-0.06555632,0.09797703,0.10128093,-2.8898372e-08,-0.019573295,-0.027014764,0.024742017,0.0025989907,0.036793824,0.041569237,0.04572138,-0.05036867,0.007266236,-0.032054212,0.0012253628,0.03725861,-0.07878997,0.010965176,-0.020731686,0.020132437,0.00936023,0.064658634,0.05939295,0.022646885,-0.011609889,0.016844707,-0.0020227921,-0.0035396877,0.0034474912,-0.11373495,0.0067644864,-0.058650084,0.06355211,-0.04700068,0.04821328,0.044648882,-0.0021689702,-0.042857997,-0.030384673,-0.027350582,-0.04601417,-0.036364753,0.033020586,-0.05582776,0.015670815,-0.053240124,-0.04115842,-0.034399576,-0.014855592,-0.016705079,0.04749546,0.024607781,-0.004428879,-0.1132516,-0.012163391,-0.006515155,0.06679127,-0.13989902,-0.07624196,-0.09543471,0.01456398,-0.04065238,-0.069219545,-0.09387467,-0.026510198,-0.017647542,0.13563998,-0.052320104 +1.14.14.105,This microsomal cytochrome-P-450 (heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).,384,1.0,-0.0126408,0.03516307,-0.08552461,-0.025732229,-0.016191792,0.028266335,0.036414064,0.08611996,0.051159993,0.040051054,0.010023617,0.017101938,-0.028637305,-0.074446216,-0.03266611,0.02075268,-0.05023183,0.013892155,0.0017992328,-0.014554032,0.06731397,0.031619318,0.007231102,0.029294927,-0.016637022,-0.022452582,-0.03280071,0.055838373,-0.022569872,-0.07787246,0.03945257,0.04456621,0.0027967447,0.01225938,0.029195482,0.06572008,-0.08452274,0.008769809,0.031042343,-0.0043520657,0.09027509,-0.033929855,-0.07779229,0.031495184,-0.0870762,-0.12158557,-0.039029893,0.003555722,0.07512372,0.042024527,-0.018817428,-0.05837076,-0.034149393,0.056253288,0.0022198407,-0.02383334,0.0545822,-0.011217504,-0.02616453,-0.034673847,-0.018679384,0.02936236,-0.028269896,0.040675703,-0.05470267,0.007874463,-0.050103612,-0.05321134,0.0010439303,-0.08188571,-0.06676399,-0.044033114,-0.00792743,0.009944299,-0.09579481,0.046612192,0.005736634,0.043655235,0.02465331,-0.05708043,0.059225988,0.072629765,-0.0030221439,0.08098756,0.059330083,0.022934688,0.060234416,0.043845274,0.09966889,-0.029956276,0.00982375,0.10589704,-0.014083167,0.007958917,-0.10916069,2.5956082e-05,0.05452481,-0.05036736,-0.039325397,0.0017711337,0.08957772,0.045136973,-0.03339542,-0.106209934,-0.09372983,0.011420198,-0.068350025,0.0017850951,-0.010262742,-0.050050437,-0.025382876,-0.0018661877,-0.034061287,0.049934153,-0.015579742,0.07961663,-0.018936446,-0.099753276,-0.0051066205,-0.097987615,-0.047262475,-0.06664114,-0.033297908,-0.020295173,-0.017167376,0.0046944325,0.03209111,1.7701057e-33,0.010777355,0.029718308,0.018698154,-0.02128151,0.07938865,0.01022632,-0.0481647,0.03020955,-0.11834784,-0.036673337,-0.12508193,-0.06656223,-0.05002451,-0.0036684705,0.013227107,-0.03112118,-0.026803097,0.044819955,0.059003327,-0.009348557,-0.03469308,0.031599917,-0.061332505,-0.07913106,-0.050682947,0.11894469,-0.058097545,0.008766504,0.046764642,0.00062557566,-0.02310555,-0.033476487,0.017850675,-0.01565074,-0.016006142,0.010569604,-0.03929373,-0.017322581,-0.055455294,0.0714588,-0.021889504,-0.008152043,0.0993824,-0.031802338,0.006530993,-0.046012435,-0.07237535,0.02031745,0.039183266,0.00046693446,0.021305317,-0.01303242,0.09966964,0.043745626,-0.07142151,0.046452634,-0.026009439,0.01946577,-0.024567429,0.06046213,0.10060782,0.00046713688,-0.057094272,0.029771034,0.009190639,0.060138848,-0.04567432,-0.027108215,0.052277625,0.12929152,-0.08106526,0.012596166,0.054882783,0.003942165,0.0913944,0.014099715,0.020146154,0.07659691,-0.025662316,0.08456275,-0.025493097,-0.010965423,-0.038707253,-0.019770226,-0.031804092,-0.01870776,0.027251901,0.06401291,-0.042627193,0.019263508,0.033630677,-0.06645189,-0.027003074,0.020696651,0.005109537,-3.306307e-33,0.028593244,-0.09347173,0.08156417,-0.06691281,-0.036898497,0.0987238,-0.023669321,-0.046706673,-0.021288749,0.080445066,0.050699845,-0.0035726384,0.030991735,-0.03445366,-0.021003513,-0.03343307,0.04207746,0.046982635,-0.054509126,-0.013987745,0.013119037,0.09596398,0.00019443067,0.0654067,-0.029991427,-0.051299855,0.056074645,0.010094635,-0.005511079,0.04558052,0.03183539,0.06252323,-0.0667719,0.017165234,-0.03631751,-0.00062584813,-0.04230944,-0.010081131,0.046338286,0.06572818,-0.08582729,0.03857049,0.012841818,0.012570704,0.039690487,0.013221178,-0.14524892,0.017031088,-0.028625935,0.019981977,0.041983005,0.0685812,-0.017037516,0.016409133,0.023118604,0.041271523,-0.053012025,-0.026114492,0.04370436,-0.04626266,-0.028487256,-0.027720056,-0.035236847,0.009435199,0.019087233,0.05867033,-0.044492636,0.045063056,0.072175264,0.01856885,0.034519397,0.052994333,-0.050879728,0.088650376,-0.03540212,0.024535222,0.021572724,-0.07216597,0.052234463,0.01169554,0.03498835,-0.021625726,-0.0070973076,-0.07246349,-0.08852999,-0.07118741,-0.012649803,0.06450118,0.02796469,0.0037758655,-0.0032494343,0.018868156,-0.03474914,0.043179113,0.054188322,-3.1010874e-08,0.0014152243,-0.045109574,-0.005614036,0.02135844,-0.039845068,-0.046170603,-0.009018481,-0.011903759,0.058988553,-0.064136535,0.02986541,0.050626088,-0.0064419503,0.026294455,-0.020588653,0.09483281,0.064561985,0.032260258,0.027519533,0.022768287,-0.06618469,-0.013264561,-0.07562323,0.044775587,0.04994934,-0.10757088,0.010412655,0.03756801,0.016933866,0.033774428,0.027470317,0.008435087,-0.077203035,-0.01728319,-0.023374146,0.09285866,-0.037450697,-0.06443718,0.04523485,0.021171868,0.062917456,-0.091815345,-0.021374194,-0.037364468,-0.07031372,0.030774886,0.038920052,-0.013431929,-0.019636638,-0.0092239035,-0.02105714,0.045558687,0.013597733,-0.12221546,-0.108841136,-0.03471089,0.00027179133,-0.040393032,-0.06369427,-0.10946756,0.04847729,0.024121342,0.24408974,0.019884465 +1.14.14.106,This cytochrome-P-450(heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).,384,1.0,-0.012659165,0.03156047,-0.0824083,-0.027073793,-0.015451294,0.03140321,0.031691197,0.082711056,0.05087086,0.027973704,0.0016052087,0.01568774,-0.022307359,-0.080659464,-0.043781847,0.02245182,-0.04198998,0.0064939335,0.009791275,-0.019341059,0.06865731,0.018587375,0.013327505,0.041978292,-0.009372829,-0.012526457,-0.031339567,0.054280315,-0.026368579,-0.087235555,0.025525345,0.021484463,-0.008982811,0.015083544,0.023476673,0.062917516,-0.085897096,0.008880405,0.036279675,-0.0026499208,0.07810592,-0.039047763,-0.07987631,0.028888755,-0.08284586,-0.110357374,-0.038229585,-0.0038069615,0.083211005,0.03565074,-0.0071640695,-0.04900569,-0.028405538,0.048271354,0.0023180766,-0.019024793,0.046804655,-0.0039983727,-0.019804722,-0.037926722,-0.008555177,0.030470368,-0.025705686,0.039927028,-0.05827505,0.007553516,-0.0525775,-0.037640642,-0.0052389423,-0.07877611,-0.0682898,-0.037609063,-0.006644545,0.008713018,-0.09876413,0.057643108,0.016649103,0.0480948,0.024754507,-0.06727191,0.096240595,0.06869164,0.00806047,0.086954996,0.059898384,0.020322736,0.051077437,0.050227858,0.10841857,-0.019747462,0.015408015,0.09935204,-0.012007747,0.0027011798,-0.11417948,0.015183899,0.04520292,-0.047182754,-0.037137225,0.009127347,0.084307045,0.04452176,-0.039669868,-0.11921485,-0.09315537,0.009545906,-0.058988795,0.004202269,-0.008324551,-0.05451883,-0.034082018,-0.004011751,-0.04048896,0.041771587,-0.03328563,0.08937027,-0.024382286,-0.09779736,-0.012872753,-0.116388835,-0.0409647,-0.07917255,-0.022535,-0.017741984,-0.016912961,0.0030440649,0.021215532,1.9412672e-33,0.016637675,0.036133084,0.012018994,-0.029343562,0.07743294,-0.008596868,-0.048921634,0.027380647,-0.11839457,-0.03918651,-0.12487976,-0.0696406,-0.05734774,-0.012010944,0.014056521,-0.018920517,-0.034627967,0.050322663,0.056470137,-0.014834466,-0.0297621,0.03277263,-0.0635548,-0.071513146,-0.045145027,0.12332066,-0.055079725,0.004043292,0.044839356,0.004726288,-0.022954075,-0.022966327,0.016924025,-0.020299466,-0.0028830713,0.009771497,-0.03814011,-0.01727189,-0.05077683,0.06671354,-0.02321341,-0.0095333895,0.10349834,-0.026623378,0.009154641,-0.043822277,-0.075982764,0.02655342,0.048255824,0.027164552,0.018176174,-0.01222375,0.10032973,0.04595707,-0.06817997,0.034031097,-0.016116407,0.025351262,-0.014025223,0.058319535,0.095321015,0.009351486,-0.06437914,0.020454887,0.008972067,0.0665808,-0.05075503,-0.03819909,0.060104266,0.124377936,-0.091521345,0.0067830854,0.029490342,3.2615608e-05,0.09151455,0.0065488466,0.010681189,0.064701565,-0.012453289,0.08394984,-0.032508507,-0.00982806,-0.025342656,-0.017512726,-0.027642714,-0.019078659,0.026146987,0.06434901,-0.040651344,0.020855006,0.04304226,-0.061051007,-0.037211884,0.023732038,0.0046826727,-3.011172e-33,0.033017952,-0.072582945,0.082442366,-0.06104484,-0.04282431,0.095171876,-0.02871675,-0.062348258,-0.010120213,0.07549236,0.059743404,-0.0074838367,0.023358563,-0.017528513,-0.023457648,-0.042482857,0.04005627,0.043710213,-0.078652546,-0.019552594,-0.0013938809,0.09476173,0.007894734,0.06241112,-0.024140157,-0.0406275,0.056605097,0.01785231,0.00992445,0.04062774,0.03296894,0.05782344,-0.06482393,0.014520169,-0.036707994,0.00524064,-0.035355687,-0.0043131826,0.044922255,0.07170423,-0.08205671,0.040172394,0.016707506,0.0163902,0.03476015,0.013960448,-0.1417172,0.017517708,-0.00977688,0.017566217,0.06913934,0.06698077,-0.008184611,0.028388297,0.034334343,0.03607384,-0.048667964,-0.028921187,0.020871336,-0.058624167,-0.02916502,-0.020842582,-0.024002273,0.0049182167,0.03272144,0.050143618,-0.050845154,0.041405734,0.076324336,0.010360217,0.028644703,0.039066285,-0.058051914,0.088603266,-0.02428174,0.01586653,0.026555598,-0.06890192,0.04852177,0.015311035,0.028383076,-0.017567387,-0.0028096214,-0.07888115,-0.09067383,-0.05734199,-0.014898566,0.062526666,0.03708001,0.0033912694,-0.001306687,0.02686459,-0.027991518,0.056903508,0.046934206,-3.019174e-08,-0.0102251675,-0.047726747,0.0004896678,0.022277674,-0.03105326,-0.042022053,-0.012321981,-0.007985088,0.05129902,-0.06979457,0.030601436,0.06506325,-0.0061066896,0.021994758,-0.022415815,0.09325936,0.060766652,0.042655498,0.026882699,0.034229733,-0.06585664,-0.020447362,-0.084369205,0.03976769,0.047997087,-0.10443406,0.0069947043,0.023098813,0.023398306,0.046141263,0.023460468,-0.00084852724,-0.07197734,-0.033932418,-0.014356399,0.101507515,-0.030112064,-0.076729454,0.041394606,0.027090108,0.064794265,-0.07275152,-0.019029906,-0.031494856,-0.06265932,0.0221357,0.035826553,-0.021959007,-0.023439134,-0.020751953,-0.022196542,0.03466059,0.0039281845,-0.12856121,-0.111802414,-0.033812627,0.005345623,-0.04017452,-0.059527684,-0.10612551,0.04537935,0.020907259,0.24688487,0.036412172 +1.14.14.107,"A cytochrome P-450 (heme-thiolate) protein from plants. Catalyses three sucessive oxidations of ent-kaurenoic acid. The second step includes a ring-B contraction giving the gibbane skeleton. In pumpkin (Cucurbita maxima) ent-6alpha,7alpha-dihydroxykaur-16-en-19-oate is also formed.",384,1.0,-0.08504074,0.005010747,-0.019168658,-0.0234956,0.035915572,0.06833684,-0.023876239,0.022087103,0.03209708,0.058906347,0.026483068,-0.034579456,-0.03426761,-0.053281695,-0.035428114,0.07244655,-0.065904334,0.071414515,0.01267734,-0.043558735,-0.03111597,-0.0037001492,0.01122844,0.02009987,0.087791,0.016432483,-0.033082362,-0.021992374,-0.064233065,-0.13392894,-0.01460174,0.011291911,0.047352053,0.013118924,-0.014489404,0.09242615,-0.07762217,-0.060049057,0.056854755,-0.055390637,0.044488117,-0.010412441,-0.07289714,-0.014271841,-0.016137663,0.0028794843,-0.03870347,0.035213888,0.009242756,-0.0461747,0.008661253,-0.049818262,-0.07394108,0.036100183,-0.0054398463,-0.01526106,-0.008288164,0.0057003857,0.0183133,0.014904628,0.07054991,0.023051193,-0.04479474,0.029820714,0.0072672246,-0.11137871,-0.029691542,-0.0018106474,-0.019559117,-0.0560971,0.038271233,-0.073074296,-0.0687045,-0.025955344,-0.07688785,0.09985443,-0.061405133,-0.0053869616,-0.02033339,-0.015087354,0.069983855,0.054728936,0.056165893,0.077243894,0.056666233,0.031630836,-0.063358925,0.06527116,-0.036075134,0.031721376,0.03820309,0.03579102,0.0062625515,0.020996481,-0.0037367952,0.023479907,0.011416829,0.0051126243,-0.010177826,-0.0062556877,0.033577915,0.09521319,-0.006673203,-0.09610725,-0.031794753,-0.014845475,-0.034091976,0.051042393,0.042156044,-0.05359144,-0.018978054,-0.10170288,0.036840793,-0.03639998,0.008159619,0.10741524,0.0379386,-0.0146174,-0.017954897,-0.05071164,-0.00031455906,-0.032495137,-0.0024021347,0.024331074,-0.14146861,0.037598375,-0.054508246,4.5612663e-33,0.116002485,0.032268118,0.022052955,0.008070546,0.020987872,0.0069114687,-0.10622031,0.0035518752,-0.0410241,-0.023673376,-0.12090409,-0.028533723,0.03893446,-0.030836163,-0.00511496,0.03839944,-0.08880651,0.018322937,0.08692009,-0.017916039,-0.043045856,-0.0015481004,-0.095315106,0.0026608636,0.0053977976,0.0391793,-0.006101584,-0.07195054,0.00045544174,-0.026060414,0.03822903,-0.041279536,-0.06752099,-0.011519557,-0.039512075,-0.060938135,-0.006468824,-0.008788488,-0.092127234,0.06109461,0.009492307,-0.029847138,0.027379591,-0.07092459,0.024947863,-0.013042781,-0.04165755,0.08206794,0.047872134,0.085049205,0.08983356,0.0065996875,0.079344206,0.043114964,-0.0755254,0.0632952,0.04172486,0.0040119737,0.04221853,0.07947237,0.06452968,0.01563785,-0.013992937,-0.02902805,-0.0041425205,0.02789394,-0.097516134,0.030742336,-0.06255163,0.10379289,-0.07810349,-0.036995444,0.060235534,-0.07738084,0.031035786,0.0013388128,-0.024544746,0.049951296,-0.03942611,0.060787633,0.04273043,0.00975842,-0.014450786,-0.0071885735,-0.0009195591,-0.0015406723,0.01273521,0.018487431,0.01117451,0.080599196,0.02650664,-0.05186584,-0.039386295,0.02094503,-0.030107507,-3.32447e-33,0.12783675,-0.10598069,0.0199232,-0.05230402,-0.008582538,0.0064766775,-0.014821693,-0.056404486,0.029202046,-0.0048920694,0.08069819,-0.033485334,0.04637697,0.005088781,0.07129015,-0.040615898,-0.024571767,0.09136056,-0.019808754,0.029305868,-0.026229024,0.058465447,-0.034504253,0.03935268,0.048662294,0.07655478,0.014323346,-0.022517705,0.07698162,0.039583273,-0.03483995,-0.020608742,-0.030008897,0.03013248,-0.06228439,0.06115567,-0.018990068,0.014056309,0.013483648,0.09164439,-0.03591587,0.09633906,0.035515223,0.06476571,0.08382458,0.013327163,-0.07198022,-0.0031285519,-0.016282083,0.015844582,0.14384368,0.012480844,-0.038108565,0.037893638,0.022469806,0.042072702,-0.034136128,0.06163609,-0.03586569,-0.056487236,-0.002132228,-0.0612334,0.036468253,-0.00798822,-0.00896913,0.075578846,-0.036710087,0.10122467,-0.0392,-0.032076467,-0.04069472,-0.0021820916,0.021650553,0.050778385,0.05019623,-0.020387359,0.019765334,0.0023956725,0.025462572,0.00089445716,-0.05368811,0.005529393,-0.03219011,-0.055344477,0.00025274133,-0.054283686,-0.05540525,0.10937278,0.07292257,-0.013463336,-0.05345955,0.056737613,0.012624016,0.12844719,0.08396627,-4.097007e-08,0.03135888,-0.09156743,0.035348367,0.005368024,0.009020417,-0.0267647,0.08299731,0.017645724,0.0034244985,-0.1028592,0.010170715,0.11237729,-0.011253595,-0.0003644447,0.036882523,0.019275023,0.012203792,0.015745996,-0.004437983,-0.01999147,-0.07656867,0.039767828,-0.005024162,0.039813332,-0.00932264,-0.059078272,0.008445978,-0.009900202,0.0289818,0.037531067,0.04067262,0.020630544,-0.045271806,-0.07292609,0.019649925,0.004693044,-0.012321211,-0.08972351,-0.0057807206,-0.016245112,-0.08460754,-0.07774377,-0.062577985,-0.025322856,-0.058874536,-0.032840744,0.027328711,0.049004577,-0.045462742,0.031077594,-0.03910403,0.018858213,-0.000682563,-0.085379876,-0.09447729,0.028698422,0.062192757,-0.04302412,0.00498311,-0.08060053,-0.019782007,-0.015678387,0.21965118,-0.027631711 +1.14.14.108,"A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid. Involved in the degradation of (+)-camphor. Requires a dedicated NADH-FMN reductase [cf. EC 1.5.1.42, FMN reductase (NADH)] [1-3]. Can accept several bicyclic ketones including (+)- and (-)-camphor [6] and adamantanone [4]. The product spontaneously converts to [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate.",384,0.99999994,-0.08878787,-0.01661835,-0.12451647,-0.02335081,0.08009549,0.08003733,-0.116569035,0.025021428,0.021083293,-0.03194818,0.05782189,-0.090675145,-0.056856148,0.07508099,-0.037269674,0.06715681,-0.052878622,0.043311514,0.010886787,0.036010507,-0.043163802,0.0508475,0.008609003,-0.0002911838,0.06477114,0.019104661,0.028646123,-0.013401206,-0.08905006,-0.041330792,-0.045378868,-0.04371613,0.044428132,-0.07925585,0.08180695,0.03831959,-0.014456707,0.011142149,0.07589614,-0.017826848,-0.03970517,-0.01849789,-0.008859698,-0.09655727,-0.07558198,-0.03416518,0.07193241,0.042519595,0.039820567,-0.06584468,-0.032766875,-0.020559557,-0.00094400294,0.0010949438,0.06593946,0.004913817,-0.029179173,-0.06313894,-0.06893099,-0.015585345,0.040485397,-0.02663508,-0.013006844,0.003172376,-0.0824544,-0.03483444,0.029191477,-0.018703219,0.000927606,-0.0359034,-0.026845274,-0.09116846,0.024806095,-0.043051083,-0.015904069,0.045390606,0.04341239,-0.05413044,0.10818381,-0.013589561,0.023609169,0.026534038,0.03051525,0.03561507,0.019247971,-0.03768114,0.073836744,0.04471334,0.057529673,0.056220222,-0.03128815,-0.030633088,-0.045755852,-0.043722823,-0.036436036,0.035002906,0.052582677,0.07141404,0.0035907938,0.0008201097,-0.0028314237,0.004461489,0.046208803,-0.06508315,-0.08772357,-0.013124571,0.03826877,0.14786932,0.025159981,-0.022746801,0.04827364,0.02555121,0.020094711,-0.0069617615,-0.086327486,0.12824106,-0.029145446,-0.12808457,-0.09790626,0.04809329,-0.0040700305,-0.0055383295,0.03149597,0.06265809,-0.010975001,0.014640059,-0.043014783,8.696651e-34,0.04573598,0.05280088,0.00930304,-0.01405573,0.07555307,0.027302848,-0.10268224,-0.015878841,-0.028382728,-0.029643554,-0.032727852,-0.057278596,0.02317252,0.03059784,-0.003067432,-0.040791508,-0.06372162,-0.028153459,0.011105352,-0.0084557645,0.013232539,0.030346256,-0.045828354,0.017342927,0.02007315,-0.028550722,0.058573104,-0.022253398,0.07151234,0.0075272494,0.02925168,-0.069459334,-0.078555584,-0.016266778,0.040521678,0.011313007,-0.079077594,-0.022864277,-0.07583037,0.05257878,0.06578081,0.13745223,-0.1035622,-0.03209138,0.047441233,-0.12070841,-0.047851253,0.18768162,0.025284704,0.13650618,-0.028096264,-0.024225706,0.034399886,0.014593793,-0.047882594,0.0374663,-0.03148859,0.03977992,0.050022103,0.013979549,-0.016413081,0.03137137,0.04046826,0.008935065,0.0381036,-0.012828595,-0.07643962,0.004071513,-0.0009060298,-0.013108583,0.01509594,0.03211829,0.01384378,0.023151487,-0.017690724,-0.08032153,-0.0055825077,0.014212509,0.020394199,-0.017548775,0.039897554,0.02229069,0.012044589,-0.056644376,-0.07918958,0.013466617,-0.040784597,-0.045719583,-0.015140106,0.06761303,0.067753956,-0.062597856,-0.02145925,-0.040851463,0.0059106327,-1.1943614e-33,0.059632543,-0.04363909,0.054979134,-0.1043543,0.008012454,0.06445733,-0.012839745,0.012092686,-0.008893519,-0.016427867,0.02098322,0.056376718,0.0687151,-0.045673672,0.028503884,-0.01733496,0.012076461,0.025515141,0.046308186,0.023802865,0.018749619,0.009694977,-0.07618618,0.046227727,0.039993502,0.069460675,-0.08131868,0.10526493,0.05860753,0.05199995,0.035866555,0.034729153,-0.07242504,0.028887555,0.0983589,0.089113064,-0.02699532,0.03358099,0.02456883,0.09041549,-0.016090905,0.012350889,-0.08975653,0.048801515,0.03238733,0.048435044,-0.12378131,0.01413346,0.06418243,-0.15998432,-0.02062183,-0.02181733,-0.048374288,-0.015353466,0.0088904,-0.011206978,0.01149833,0.028783813,0.02033886,-0.07237199,-0.039810155,-0.08693829,-0.0032028877,-0.021200625,-0.01753179,-0.009068084,0.01850936,-0.0060764104,-0.0090822885,-0.0045626066,0.0053331065,0.009475696,-0.0014074085,0.01338077,-0.032144077,-0.06379197,0.018879078,-0.028111683,-0.0019903868,-0.024163691,0.055330254,-0.07973271,-0.0009432942,-0.07908584,0.048309926,-0.015809683,0.067897104,0.07418853,-0.064156376,-0.008848797,0.015404942,0.008950063,-0.046180565,0.07359937,0.07069085,-4.780612e-08,0.09225881,-0.1285014,0.037656948,0.014775481,-0.025023121,0.01616937,0.050772622,-0.046311352,0.031420797,-0.080201946,0.009686251,0.056187995,0.036505576,-0.009385953,0.033619486,0.030346792,-0.09187868,0.03866723,-0.03159866,0.035252016,-0.07510634,-0.0068245963,-0.060168143,-0.00969945,-0.054069705,-0.020318367,0.06344857,0.0061320346,0.018954322,-0.03522572,0.057475727,0.050095875,-0.0037613625,-0.001958574,-0.09916406,-0.03538887,-0.0359546,0.050282527,-0.07001737,0.032130357,0.04476735,-0.043337394,-0.0635989,0.013272689,0.018807849,0.0017809835,-0.00046422426,0.02552885,-0.015926365,-0.0042949026,0.03614105,0.026292106,0.020625649,0.0008843984,-0.06507229,0.08841385,0.024857046,0.007276526,-0.049050987,-0.023759197,-0.0065094116,0.021258788,0.09514724,0.01946043 +1.14.14.109,"A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).",384,1.0,-0.09918082,0.057978753,-0.052081846,-0.028475152,0.045059193,0.101815574,-0.0012057868,0.0837863,0.037524957,0.01598472,0.040334057,-0.0022475836,-0.040126543,0.0024149877,-0.056053944,0.08147508,-0.049337726,0.01908755,-0.027751755,-0.079380795,-0.027447352,0.090139344,0.03313592,0.023312282,-0.014426131,-0.013098231,-0.016419014,0.06815265,-0.012954616,-0.051570993,-0.029300056,-0.015204411,0.09004193,-0.02288825,-0.003168156,0.09915677,-0.060770568,-0.088444114,0.023567036,-0.011971036,0.079201326,-0.022642974,-0.10042722,0.023625508,-0.05439369,0.006328173,0.04402703,0.04854074,-0.00058662536,-0.02249312,0.011744713,-0.028704645,-0.046538826,0.010868814,-0.057250515,0.012304297,0.023676807,0.024666173,-0.071696095,-0.043312345,-0.030243564,0.04028815,-0.05415165,0.03638041,0.00657713,-0.05200328,-0.013009462,-0.009351916,0.015662251,-0.08360305,-0.020756336,-0.09914341,-0.039482683,0.04572321,-0.112126246,0.09013561,-0.06529455,0.017124435,-0.0068267733,-0.031992648,0.0637786,0.012006118,-0.007214276,0.10901385,0.06270825,0.0065780003,-0.03463358,0.08799748,-0.018286765,-0.035528895,0.007817663,-0.047438692,-0.0299624,0.044773318,-0.103852876,0.07911729,0.061353203,-0.058275655,0.0011241644,-0.022115272,0.0645199,0.047706455,0.046137225,-0.09246214,-0.05770794,0.012470043,-0.049222194,0.024483258,0.042754345,-0.08718717,-0.07175594,-0.020856645,-0.009209781,-0.022198077,-0.0040254705,0.05671795,0.008640791,-0.034421816,0.0065345373,-0.017116584,-0.061182316,-0.006080076,0.008335292,0.06351233,-0.032914203,0.02995268,-0.14827047,9.9663655e-34,0.10182551,0.025411723,-0.0221921,0.015656726,-0.039835263,0.018679002,-0.06189119,-0.0042946464,-0.05334947,-0.00038470456,-0.07963497,-0.10830841,0.05334182,-0.065617345,-0.02817999,0.009223544,-0.06683308,0.033626374,0.056916084,0.009097138,-0.07598818,0.021468582,-0.09065979,0.021042803,0.027838847,0.110799104,0.004920781,-0.051869538,0.0025495347,0.0032007785,-0.0480891,-0.06347974,-0.07079486,-0.04425673,0.033678003,-0.031672195,-0.049370784,-0.04057355,-0.043311354,0.043757707,-0.05247641,-0.032767992,0.032147013,-0.040987097,0.059735637,-0.02553588,-0.14110251,0.055846523,-0.00026397384,0.062405556,0.07515623,-0.073932305,0.13377467,0.050833248,-0.09314967,0.0049318066,0.01653058,0.075272165,-0.002193335,0.054528654,0.09603882,0.04653793,-0.0739723,0.04045766,0.034870204,0.01137726,-0.06736016,-0.015981086,-0.020902228,0.1640933,-0.028678702,-0.034809597,0.031034674,0.004385971,0.053971846,-0.026671981,-0.0010599956,0.06569466,0.048800252,0.08146071,0.013094977,-0.04131228,-0.018341599,-0.05571471,-0.04787155,-0.0023235104,0.05278749,0.0050909724,-0.0196724,0.0074441317,0.08829586,-0.06810587,0.014680745,0.01447787,-0.0053605046,-2.0761041e-33,0.07703547,-0.040484864,0.054835923,-0.071308106,-0.021437977,0.048579343,-0.016576558,-0.0425703,-0.013463749,0.034496047,0.06840228,-0.025788175,0.018057417,-0.0046400973,0.027897952,-0.029348286,-0.028245382,0.040438343,0.009232983,0.072174676,-0.05862056,-0.024205035,0.020335255,0.03318698,0.022105897,0.007071608,-0.018654406,0.0035027966,0.046229083,0.017424446,-0.039957236,0.020841766,-0.07765828,-0.026495242,-0.019643923,0.037270363,0.007214088,0.02255355,0.035010155,0.019866232,-0.0416018,0.048648257,0.07662014,0.07196687,0.0408345,0.08879701,-0.0982837,-0.024778733,-0.062901825,-0.0007553492,0.025802258,0.060750514,0.03937734,0.06617481,0.005461642,-0.017993053,-0.013044036,0.012553991,-0.047208484,-0.041517496,-0.010703137,-0.03158539,-0.034220427,0.1066403,-0.022973277,0.07193631,-0.058319107,0.0656651,0.0036032586,0.006211196,0.011560382,0.010904744,0.043709405,0.06155793,-0.014539141,0.015336598,0.021475893,-0.02920856,0.030112078,-0.0052460516,0.002037399,0.01888836,-0.05356198,-0.05785992,-0.015722943,-0.07380701,-0.056169827,0.119143784,0.06398656,-0.02834427,-0.0094815595,0.0711629,-0.04110628,0.06318708,0.055299416,-3.4050903e-08,-0.032808788,-0.09526097,-0.00019547023,-0.035396084,0.0383708,-0.023042217,0.013914899,-0.002919575,0.060760453,-0.00872802,0.00016932053,0.038385857,-0.0352624,-0.011122377,0.04870069,0.016039629,0.024893073,0.02536336,0.028206205,0.049332973,-0.035492823,0.029122692,-0.047888312,0.0426745,0.04862024,-0.07243344,0.013030913,-0.040357754,0.055427667,0.012813913,0.045201994,0.038654692,-0.049650837,-0.00590655,-0.015609985,0.076112956,-0.0039792564,-0.06806348,-0.023151219,-0.018268168,-0.022986092,-0.059179813,-0.058123067,-0.03773824,0.03826862,-0.005025452,0.030454468,0.024695408,-0.017092135,-0.020521903,-0.040761787,0.0061095,0.019467391,-0.099318124,-0.12125942,-0.004532937,0.076570824,-0.0540726,-0.015211017,-0.09118583,-0.02581718,0.010934289,0.2125189,-0.007907828 +1.14.14.110,"A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).",384,1.0,-0.09918082,0.057978753,-0.052081846,-0.028475152,0.045059193,0.101815574,-0.0012057868,0.0837863,0.037524957,0.01598472,0.040334057,-0.0022475836,-0.040126543,0.0024149877,-0.056053944,0.08147508,-0.049337726,0.01908755,-0.027751755,-0.079380795,-0.027447352,0.090139344,0.03313592,0.023312282,-0.014426131,-0.013098231,-0.016419014,0.06815265,-0.012954616,-0.051570993,-0.029300056,-0.015204411,0.09004193,-0.02288825,-0.003168156,0.09915677,-0.060770568,-0.088444114,0.023567036,-0.011971036,0.079201326,-0.022642974,-0.10042722,0.023625508,-0.05439369,0.006328173,0.04402703,0.04854074,-0.00058662536,-0.02249312,0.011744713,-0.028704645,-0.046538826,0.010868814,-0.057250515,0.012304297,0.023676807,0.024666173,-0.071696095,-0.043312345,-0.030243564,0.04028815,-0.05415165,0.03638041,0.00657713,-0.05200328,-0.013009462,-0.009351916,0.015662251,-0.08360305,-0.020756336,-0.09914341,-0.039482683,0.04572321,-0.112126246,0.09013561,-0.06529455,0.017124435,-0.0068267733,-0.031992648,0.0637786,0.012006118,-0.007214276,0.10901385,0.06270825,0.0065780003,-0.03463358,0.08799748,-0.018286765,-0.035528895,0.007817663,-0.047438692,-0.0299624,0.044773318,-0.103852876,0.07911729,0.061353203,-0.058275655,0.0011241644,-0.022115272,0.0645199,0.047706455,0.046137225,-0.09246214,-0.05770794,0.012470043,-0.049222194,0.024483258,0.042754345,-0.08718717,-0.07175594,-0.020856645,-0.009209781,-0.022198077,-0.0040254705,0.05671795,0.008640791,-0.034421816,0.0065345373,-0.017116584,-0.061182316,-0.006080076,0.008335292,0.06351233,-0.032914203,0.02995268,-0.14827047,9.9663655e-34,0.10182551,0.025411723,-0.0221921,0.015656726,-0.039835263,0.018679002,-0.06189119,-0.0042946464,-0.05334947,-0.00038470456,-0.07963497,-0.10830841,0.05334182,-0.065617345,-0.02817999,0.009223544,-0.06683308,0.033626374,0.056916084,0.009097138,-0.07598818,0.021468582,-0.09065979,0.021042803,0.027838847,0.110799104,0.004920781,-0.051869538,0.0025495347,0.0032007785,-0.0480891,-0.06347974,-0.07079486,-0.04425673,0.033678003,-0.031672195,-0.049370784,-0.04057355,-0.043311354,0.043757707,-0.05247641,-0.032767992,0.032147013,-0.040987097,0.059735637,-0.02553588,-0.14110251,0.055846523,-0.00026397384,0.062405556,0.07515623,-0.073932305,0.13377467,0.050833248,-0.09314967,0.0049318066,0.01653058,0.075272165,-0.002193335,0.054528654,0.09603882,0.04653793,-0.0739723,0.04045766,0.034870204,0.01137726,-0.06736016,-0.015981086,-0.020902228,0.1640933,-0.028678702,-0.034809597,0.031034674,0.004385971,0.053971846,-0.026671981,-0.0010599956,0.06569466,0.048800252,0.08146071,0.013094977,-0.04131228,-0.018341599,-0.05571471,-0.04787155,-0.0023235104,0.05278749,0.0050909724,-0.0196724,0.0074441317,0.08829586,-0.06810587,0.014680745,0.01447787,-0.0053605046,-2.0761041e-33,0.07703547,-0.040484864,0.054835923,-0.071308106,-0.021437977,0.048579343,-0.016576558,-0.0425703,-0.013463749,0.034496047,0.06840228,-0.025788175,0.018057417,-0.0046400973,0.027897952,-0.029348286,-0.028245382,0.040438343,0.009232983,0.072174676,-0.05862056,-0.024205035,0.020335255,0.03318698,0.022105897,0.007071608,-0.018654406,0.0035027966,0.046229083,0.017424446,-0.039957236,0.020841766,-0.07765828,-0.026495242,-0.019643923,0.037270363,0.007214088,0.02255355,0.035010155,0.019866232,-0.0416018,0.048648257,0.07662014,0.07196687,0.0408345,0.08879701,-0.0982837,-0.024778733,-0.062901825,-0.0007553492,0.025802258,0.060750514,0.03937734,0.06617481,0.005461642,-0.017993053,-0.013044036,0.012553991,-0.047208484,-0.041517496,-0.010703137,-0.03158539,-0.034220427,0.1066403,-0.022973277,0.07193631,-0.058319107,0.0656651,0.0036032586,0.006211196,0.011560382,0.010904744,0.043709405,0.06155793,-0.014539141,0.015336598,0.021475893,-0.02920856,0.030112078,-0.0052460516,0.002037399,0.01888836,-0.05356198,-0.05785992,-0.015722943,-0.07380701,-0.056169827,0.119143784,0.06398656,-0.02834427,-0.0094815595,0.0711629,-0.04110628,0.06318708,0.055299416,-3.4050903e-08,-0.032808788,-0.09526097,-0.00019547023,-0.035396084,0.0383708,-0.023042217,0.013914899,-0.002919575,0.060760453,-0.00872802,0.00016932053,0.038385857,-0.0352624,-0.011122377,0.04870069,0.016039629,0.024893073,0.02536336,0.028206205,0.049332973,-0.035492823,0.029122692,-0.047888312,0.0426745,0.04862024,-0.07243344,0.013030913,-0.040357754,0.055427667,0.012813913,0.045201994,0.038654692,-0.049650837,-0.00590655,-0.015609985,0.076112956,-0.0039792564,-0.06806348,-0.023151219,-0.018268168,-0.022986092,-0.059179813,-0.058123067,-0.03773824,0.03826862,-0.005025452,0.030454468,0.024695408,-0.017092135,-0.020521903,-0.040761787,0.0061095,0.019467391,-0.099318124,-0.12125942,-0.004532937,0.076570824,-0.0540726,-0.015211017,-0.09118583,-0.02581718,0.010934289,0.2125189,-0.007907828 +1.14.14.111,A cytochrome P-450 (heme-thiolate) protein. The enzyme from rice (Oryza sativa) is involved in the biosynthesis of the phytoalexin momilactone. It also acts similarly on 9beta-stemod-13(17)-ene.,384,1.0,-0.09683137,-0.017327325,-0.06054168,0.00911368,0.061411105,0.10659718,-0.05748604,0.062469974,0.014390305,-0.00077010563,0.116004705,-0.0023284478,-0.037701853,0.029782852,-0.020560402,0.05106178,-0.049943827,0.03348579,-0.056420945,-0.100598626,0.03445217,0.08217365,0.034726206,0.012628823,0.036297765,-0.024601161,0.04799936,0.05784343,0.019133756,-0.049906667,-0.07684071,-0.037602235,0.03168708,0.010997152,0.016356174,0.09593287,-0.0412329,-0.12928471,0.023297472,-0.084543675,0.08177305,-0.025567075,-0.025772404,-0.009452937,-0.022122264,-0.046948392,0.012801519,-0.04068528,0.03627115,-0.055134017,-0.023513354,-0.035629734,-0.023547957,0.051080134,-0.025778873,-0.004298078,0.023470523,0.020365361,-0.03160883,0.014215209,-0.057052672,0.060560975,-0.041914046,0.016374828,0.003334303,-0.019681826,-0.038157802,-0.0003676261,-0.018349253,-0.08096282,0.04445935,-0.090170614,0.010273907,0.07000559,-0.031772118,0.032521952,-0.0131678535,0.040141005,-0.017485961,-0.044670478,0.015987214,0.027986892,0.042778257,0.14564727,0.031697135,0.01031024,-0.06939455,0.0736809,0.019716937,-0.056206163,0.025161738,0.0050179353,-0.028267954,0.034937724,-0.036972567,0.07039676,-0.0012732549,-0.0594719,-0.00064516487,-0.014713605,0.04846482,0.08974446,-0.08175788,-0.052358296,0.00245005,0.024730993,-0.026687428,0.051733207,0.02207249,-0.009084197,-0.009288816,-0.030505013,0.017921317,0.016993653,-0.054777917,0.01620736,0.00880685,-0.026470613,-0.042669833,-0.07632411,-0.019836409,-0.029773902,-0.034965254,0.006956054,-0.049283568,-0.0014953457,-0.13407148,1.921531e-33,0.11760706,0.045493536,-0.013980693,-0.02067406,0.04261887,-0.030627755,-0.021663234,0.00029718954,-0.009695567,-0.011572409,-0.14970528,-0.08069514,-0.024794322,-0.054921087,-0.0019367711,-0.023075221,-0.080625355,0.021805117,0.07006971,0.03601943,-0.04380761,0.03461543,-0.06544541,-0.04215808,0.002695237,0.04315861,0.0061789653,-0.039836437,0.0187359,-0.015972346,-0.057997238,-0.04063206,-0.08469646,-0.0851673,0.011213188,-0.074978374,0.015099681,-0.039893318,-0.077166535,0.055062663,-0.008907249,0.017212769,-0.011140635,-0.06665522,0.09682498,0.0033390839,-0.08915004,0.09639986,0.0083711585,0.04058537,0.0561172,-0.039541356,0.106286936,0.0809529,-0.052652687,0.019573051,0.025445202,0.0017160329,-0.00299509,0.08114314,0.032829527,-0.025943419,0.0026351744,0.09222855,0.021849891,0.019233478,-0.08011036,-0.028425707,-0.044596154,0.115946546,-0.061175495,-0.05413297,-0.029235052,-0.03354173,-0.0031816997,-0.036265247,-0.04123128,0.03979324,0.028455729,0.0065036784,0.058519304,-0.008967499,0.018322058,-0.015991662,-0.032089207,0.028438723,-0.014391021,-0.031601608,0.011565112,-0.021442141,0.06836854,-0.058982767,0.028141294,0.009657775,-0.055975772,-1.9235167e-33,0.053317845,-0.029401397,0.056466732,-0.07578988,-0.005674889,-0.059631865,0.011270196,0.019161629,0.035785045,0.03792892,0.095701665,-0.06176685,0.047268536,-0.048321944,-0.02247986,0.0760913,-0.01763789,0.10824193,-0.0059455144,0.048941772,-0.05090391,0.055134583,-0.024838464,-0.006632022,0.03540302,0.04577918,0.009909152,0.088424936,0.023722228,0.03197979,0.016708337,-0.0324935,-0.058856275,-0.021474412,-0.013314448,0.055742886,0.014856052,-0.04076355,0.057040423,0.054183222,0.02656328,0.07254866,0.059068926,0.05391258,-0.01682226,0.07072063,-0.09216917,0.02501168,-0.045721274,-0.057734128,0.008695505,-0.026673025,0.03204822,0.05909869,-0.041781746,-0.005015754,0.041312896,0.016934246,-0.06412242,-0.058108043,0.014366799,-0.02127812,-0.018844372,0.052737236,0.0019817906,0.07165725,-0.017458268,0.028020449,0.015047478,0.048097223,0.017847681,-0.016634354,0.051962975,0.08597321,-0.028674666,0.0027384425,-0.013367202,-0.00045979617,0.07624921,0.036927417,-0.0003058473,0.009645635,-0.03622153,-0.08776494,0.019326909,-0.027556812,-0.012980451,0.16244562,0.10458961,0.0046383813,0.009771812,0.011654794,0.0030333675,0.07347903,0.05418885,-3.8382066e-08,0.047536474,-0.13752241,-0.021580188,-0.017040307,-0.056435782,-0.06579223,0.03046552,0.011867956,0.0760053,-0.022698022,-0.037425853,0.06055334,-0.0844505,-0.043751508,-0.0100255245,-0.001443799,0.059744887,0.10030575,0.0075134453,-0.047071643,-0.03007313,-0.01840422,-0.013673412,0.02988964,0.024783252,-0.048746202,-0.037515674,0.019169576,0.05661937,0.0052224053,-0.009824442,0.014708966,-0.0038582564,-0.04388572,-0.021507384,0.08500879,-0.00822387,-0.066507384,0.019262295,-0.050350506,0.0010434649,-0.06655657,-0.045885324,-0.032404937,0.03280447,-0.010428194,0.03968093,0.06539063,0.035214245,-0.0014024973,-0.022836737,-0.0547071,0.032057203,-0.14402221,-0.096587524,-0.0040579485,0.024830393,-0.007293644,-0.033269178,-0.0664968,0.015421898,0.034372043,0.23187591,-0.04828796 +1.14.14.112,A cytochrome P-450 (heme-thiolate) protein. The enzyme from rice (Oryza sativa) is involved in the biosynthesis of the antifungal phytocassanes.,384,1.0,-0.09244834,0.05105875,-0.07583909,0.038445182,0.030285219,0.0947833,-0.052950878,0.032146633,0.018009981,0.0062093637,0.11385383,0.0055036265,-0.048723407,0.014925235,-0.044697996,0.04381204,-0.040481765,0.05212997,-0.0844455,-0.13446724,0.0079327915,0.07421121,0.03922146,0.009025735,0.022796538,-0.021539217,0.009795151,0.06865763,0.027880164,-0.072502196,-0.06991972,-0.012616831,0.050305538,-0.023172377,0.007550727,0.07805554,-0.026256345,-0.068261474,0.07681932,-0.05922056,0.060113497,-0.04471978,-0.04749641,0.02501252,-0.023373498,-0.04392652,-0.027161581,-0.013067987,0.04095838,-0.0726472,-0.04289825,0.040293463,-0.06637884,0.04126172,-0.043883897,-0.02009105,0.04523751,-0.017340366,-0.0521798,0.0059379986,-0.022862239,0.018607356,-0.051674698,0.052023165,-0.062131494,-0.020017128,-0.054623894,-0.0136353765,0.019033207,-0.045933902,-0.011416892,-0.10425058,0.0044788886,0.058687683,-0.016808905,0.05361859,0.03901617,0.03565285,-0.029437507,-0.03552847,0.06563734,0.0032585086,0.05290898,0.112093695,0.00012978907,0.018483223,-0.06602693,0.09723594,0.024789585,-0.06753287,0.038222957,0.04612191,-0.008590419,0.038867123,-0.0460922,0.0893051,0.0039244886,-0.029266683,-0.02240263,-0.014737626,0.054131866,0.0268806,-0.04409321,-0.063261494,-0.0026760157,0.010356847,-0.011488011,0.037771367,0.05339646,-0.035688743,-0.010610849,-0.03195648,-0.0068692164,0.021709794,-0.05994984,0.010103823,0.03401454,0.0012236448,0.009874066,-0.105006106,0.014579638,-0.017975226,-0.022719162,0.0054559736,-0.06417206,-0.03552317,-0.12196483,1.9107767e-33,0.07651065,0.064902835,-0.0045789834,-0.033432327,0.02466005,-0.03874848,0.0035824736,-0.024293143,0.005711932,-0.016600644,-0.1304531,-0.06536786,-0.05312864,-0.0013948306,-0.0025260246,0.0041012443,-0.06955192,0.011161412,0.018141294,0.021598134,-0.036014784,0.029763443,-0.10923952,-0.011164264,0.06371626,0.09107424,-0.0042136833,-0.045756135,0.014029762,-0.023793776,-0.032291472,-0.03068078,-0.061098482,-0.064365685,-0.0025709828,-0.075802274,0.012313476,-0.019823039,-0.073786974,0.049293343,-0.03515853,0.025168769,-0.021768326,-0.03012768,0.06110422,0.0044837035,-0.11139793,0.081970885,-0.0214597,0.062133092,0.045923464,-0.038878657,0.09166487,0.11996683,-0.048941284,-0.023803234,0.038436778,0.036395907,-0.00393472,0.04688717,0.023350963,0.007036489,-0.016712125,0.09028399,0.008907126,-0.021575829,-0.06938367,-0.061926585,-0.021248553,0.11628377,-0.06374934,-0.042560108,-0.008224029,-0.028309772,0.010465565,-0.08863555,-0.075713985,0.014475469,-0.004535164,0.0939633,0.07231881,-0.03400339,0.011738676,-0.0063094506,-0.06603003,0.017561221,-0.009512511,-0.008087164,0.034382597,-0.016999517,0.07171739,-0.030520873,-0.006392594,0.059163004,-0.024660118,-2.3551419e-33,0.09818578,-0.0613808,0.050061315,-0.018629484,-0.044219147,-0.0016806313,0.0061927624,-0.019527549,0.030165514,0.010927804,0.09320581,-0.04879937,0.041514795,-0.034357302,-0.004688027,0.049012482,0.02455077,0.09183671,-0.027582176,0.10035151,-0.050722033,0.08808301,0.005954115,-0.010677095,0.06161404,0.033723094,0.057048414,0.043490764,-0.02670574,0.010887597,0.028504683,-0.04238222,-0.05854155,-0.08183622,0.0067157377,0.044044424,0.043581486,-0.034269385,0.025107423,0.048219297,0.008847895,0.07485844,0.016633833,0.04810305,-0.024384858,0.089166604,-0.0971688,0.026860638,-0.03924287,-0.06781314,0.014078965,0.029582152,0.0061240694,0.06959819,-0.025369057,-0.03210073,0.010583031,0.012813197,-0.025624873,-0.03661048,-0.014819921,-0.04878268,0.0008917334,0.05079211,0.022061335,0.114998125,-0.009131872,0.065490425,0.067010574,-0.013406601,0.01777326,0.014710428,0.03908026,0.109942384,-0.059823975,0.053108104,-0.0031425243,-0.046128757,0.051611617,0.050029416,-0.004922186,-0.0113875205,-0.032306757,-0.04144112,-0.030536992,-0.034066305,-0.037908472,0.16360608,0.01898961,-0.00020288015,0.03176008,-0.0027740293,-0.0035263016,0.092131004,0.06561717,-3.4699468e-08,0.011736342,-0.14348605,-0.026606213,-0.044343803,-0.05196731,-0.021024963,0.047130164,0.0072525167,0.09599588,0.0066938926,-0.033727832,0.053010758,-0.061166454,0.0155474115,-0.02158986,0.00273492,0.058368187,0.09454658,0.036781717,-0.01680589,-0.030162614,-0.018598119,-0.08467744,-0.014113812,0.05074559,-0.057486754,-0.008717181,-0.03371401,0.07456434,-0.026814194,-0.015518581,-0.012559352,-0.000205585,0.013908675,0.016610648,0.086197026,-0.02360193,-0.09622472,0.023169497,-0.034262393,0.019587748,-0.05393808,-0.036336876,-0.03358894,0.0028285626,-0.044034548,0.041139446,0.038186003,-0.017313672,-0.054827563,-0.017977262,-0.01449106,0.017650863,-0.14006972,-0.10674822,-0.0065062344,0.06347471,0.008254629,-0.048756853,-0.07682403,0.00580614,0.0063478267,0.18126565,-0.021531684 +1.14.14.113,A cytochrome P-450 (heme-thiolate) protein. The recommended numbering of humulene gives 10-hydroxy-alpha-humulene as the product rather than 8-hydroxy-alpha-humulene as used by the reference. See {iupac/sectionF/index::Section F: Natural Product Nomenclature}.,384,1.0,-0.017367054,-0.022487555,-0.0042062392,-0.06865308,-0.00092601107,0.027998399,0.007786974,0.10275392,0.048274335,-0.038142413,0.004446577,-0.018084016,-0.043403547,0.049623888,-0.05988361,0.017823212,-0.023087261,-0.0094066,0.021882484,-0.0406306,0.014436534,0.08136768,0.085537255,0.055571042,-0.06767734,-0.0076913587,-0.012738082,0.02367987,-0.0077091735,-0.08743172,-0.014491318,0.025266461,0.114179075,-0.032482732,0.016132712,0.069104195,-0.027942898,-0.04070989,0.018539447,-0.019625109,0.12177332,-0.09793555,-0.010716931,0.016991772,-0.050878618,-0.026735675,-0.0028302153,0.025363803,0.06024797,0.110393785,-0.011767817,-0.0754101,-0.12452221,0.09766635,0.023346256,-0.028452355,-0.039327223,-0.029198715,-0.02542122,0.0036921958,-0.049414407,0.051695548,0.009298873,-0.025980186,0.08372403,-0.04914468,-0.034910865,-0.05140175,-0.02862119,0.027642976,0.047744945,-0.09258935,-0.04842903,0.08789799,-0.0926211,0.124780335,-0.02131427,-0.019731266,0.050014865,-0.038286775,-0.04379449,0.057402633,-0.024024043,0.074676625,0.03163048,-0.0018850327,-0.03593349,0.030877825,-0.06614297,-0.07560006,0.00499147,0.014693889,-0.0085759405,-0.01356858,-0.030155752,0.023885302,0.046686545,0.039061677,0.000695398,-0.008791959,0.069870114,0.005212161,-0.013097209,-0.15269202,-0.08908338,-0.014644876,-0.014822008,-0.03538827,0.03734382,-0.085146934,-0.05846701,-0.010134088,-0.03739912,-0.018062018,-0.0015188496,0.051601186,0.0016550262,0.025534553,0.031046402,-0.054479577,-0.052202564,-0.020736406,0.096896105,0.0009934127,-0.048931647,0.01779293,-0.1281944,3.2620104e-33,0.018209664,-0.034318637,0.06760406,0.05316413,-0.040895816,0.0041079107,-0.065332785,0.02958781,0.011819035,0.009269036,-0.06366607,-0.005252098,-5.3386197e-05,0.017683888,-0.05691814,-0.05734927,-0.036868047,0.030424954,0.020025268,-0.05875135,-0.045074023,0.0859786,0.03448258,0.024784131,0.04330555,0.0003346156,-0.009237297,-0.059863973,0.033046365,-0.0076644905,-0.0040892805,-0.054215536,-0.022953618,-0.072920606,-0.019248629,-0.035679854,-0.06982553,-0.03178022,-0.053509742,0.09297633,0.02623017,-0.07069559,-0.0037919714,-0.039250802,0.06765878,-0.02668494,-0.08445389,0.017498216,0.0065865293,-0.016172562,0.049705897,-0.02503464,0.09823066,-0.050936595,-0.08820102,-0.028540762,-0.013209138,0.037851274,-0.022520917,0.048484035,0.071486555,0.07387891,0.0049992343,0.033873502,0.020643689,0.05979423,-0.08346949,0.025196638,-0.008608157,0.12892339,0.041653093,0.06119631,0.07837781,-0.022013005,0.061669543,-0.010285732,-0.06784951,0.049365293,0.03281571,0.011596006,-0.014190057,0.022150483,-0.013833011,0.05521179,-0.06617034,0.011218491,0.05193408,0.048249785,-0.014526746,0.081103854,0.011115238,-0.024394218,-0.05467511,-0.005339322,-0.06308343,-3.7765952e-33,0.032851458,-0.07903874,0.044580244,-0.016704366,0.038329735,0.019119099,0.10122705,-0.023646012,0.023281354,0.0009971269,0.13694312,-0.02615353,0.017938446,-0.08954485,0.026167613,0.07900003,-0.101497814,-0.006976565,0.008958304,0.051020592,-0.055380058,0.024021646,-0.0045371763,0.058659516,0.00776794,0.028437346,0.009767273,-0.010809788,0.10793604,0.0071955295,-0.075474516,0.060252104,-0.000142467,-0.066341855,-0.028411904,0.0034909798,0.06443923,-0.045703027,-0.04491445,-0.0222713,-0.06060957,0.07652077,0.06165575,0.04769762,0.055964578,0.05038841,-0.04334925,-0.051694814,-0.07838111,0.051523373,0.05986657,-0.06364656,-0.00841856,0.0016549797,-0.0064120954,0.025892595,-0.10008562,0.05053551,0.058608044,0.022533389,-0.036993697,-0.04692208,-0.011275325,-0.0011471997,-0.004552294,0.036582917,-0.083283,0.02737547,-0.039544307,0.008139596,0.07818459,0.02759499,0.042635094,0.066803694,0.016990652,0.0121258,0.058465704,0.008483952,0.054217193,-0.041139804,-0.051777083,0.012914654,-0.08765547,0.0072154934,0.034424756,0.019303197,-0.0046823476,0.06759306,0.023796529,0.030261165,-0.014934367,0.014804959,-0.13091737,0.07094825,0.066034675,-4.4067097e-08,0.035767812,-0.12431109,0.039069615,-0.0047119134,0.07558808,0.017369794,-0.002492488,0.022261385,0.047621906,-0.028098805,-0.0014023823,0.01705681,0.020429635,-0.014142932,-0.034267224,-0.054562237,0.014368294,0.029331546,0.010539384,-0.031061437,-0.067406386,0.05360358,-0.01836081,0.037083723,0.006075907,-0.086392574,-0.00042855754,-0.015407106,-0.012542688,-0.03998242,0.069152296,0.035357945,-0.029447822,-0.09483432,0.051882405,0.09541811,-0.02978172,-0.027819995,0.00060353044,0.018328669,-0.037494708,-0.054774746,-0.047778666,-0.058156256,0.028583411,-0.07693782,-0.017841388,0.04113176,-0.041461006,-0.017571298,0.019453265,0.027549645,0.0081069525,-0.10339297,-0.050891582,-0.0043710577,0.045098126,-0.07330202,-0.026980791,-0.06772484,0.05108112,-0.042015314,0.18023716,-0.009265127 +1.14.14.114,A cytochrome P-450 (heme-thiolate) protein. Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin.,384,1.0,-0.12159376,0.025002807,-0.009891554,-0.04708032,0.07457075,0.06550721,-0.0036787281,0.023533028,0.033356197,0.036712494,0.055333983,0.00068071974,-0.08643608,-0.047206182,-0.0560556,0.053352524,-0.068111464,0.048887346,-0.03792259,-0.055365726,0.022450738,0.08654439,0.025261853,0.028649017,0.021306042,0.01736253,-0.0061734677,0.0641515,0.0075162775,-0.04554895,-0.015789952,-0.0066112895,0.011106613,0.015569124,-0.066359706,0.15479717,-0.03927513,-0.09883354,0.06852223,-0.07067762,0.10453961,-0.055104814,-0.071193025,-0.019917352,-0.062465217,-0.009760886,-0.016461466,0.014408518,0.0752891,0.0063607874,-0.026201265,-0.06635145,-0.046590615,0.008112854,-0.02454922,0.013454912,0.039798245,0.010157703,-0.00788787,-0.0004303126,0.0122845,0.08203624,0.0055221138,0.05512218,-0.011107049,-0.011508766,-0.056761604,-0.028414346,-0.001896992,-0.08773921,0.004981079,-0.08348381,-0.020957986,0.037266374,-0.052670423,0.074602686,-0.028939705,0.019352874,-0.017937554,-0.0044819657,-0.016664555,0.032737643,0.032122582,0.1735823,-0.038486887,-0.0077009695,0.0026242526,0.09100097,-0.024249911,-0.07057991,0.013852043,-0.0034913786,0.020299932,0.008027213,-0.0671446,0.09719329,0.016199144,-0.027481461,0.027899366,-0.021124491,0.016500654,0.053072028,-0.033779867,-0.117823936,-0.09799065,0.02666938,-0.04842115,0.016258478,0.060172215,-0.05848016,-0.043664053,-0.010854085,0.025624754,0.0027212228,-0.04425461,0.032369178,-0.051038977,-0.011192737,0.013543081,-0.03065241,-0.050760627,-0.008557418,0.034783453,0.028280336,-0.03549974,-0.010261771,-0.091203004,8.682045e-34,0.12125621,0.033090778,0.037377927,0.03227974,0.005619297,-0.02159986,-0.020583734,0.043501172,-0.029148176,-0.041676354,-0.10872295,-0.116386734,0.002431455,-0.057815135,-0.0343422,0.02282122,-0.025279243,-0.005999824,0.0876966,0.04389387,-0.05973938,0.03134836,-0.042847607,-0.03579843,0.015449364,0.08636618,-0.011124416,-0.023127193,0.023690369,-0.002260391,-0.02530627,-0.07534203,-0.021321943,-0.029575096,0.04826381,-0.016018279,0.00021718892,-0.019127216,-0.07527412,0.05378487,-0.024671925,0.034049418,0.06970914,-0.075358465,0.049745627,-0.0034432115,-0.12631536,0.06974839,0.026209952,0.0498013,0.034047976,-0.0035864303,0.12430787,0.044102605,-0.06961101,0.022467783,0.0038468984,0.022893785,0.012468279,0.03192095,0.08636042,0.0031800063,-0.03393971,0.041474164,0.07892465,0.095134474,-0.03458839,-0.008758281,-0.035825003,0.08634333,-0.07057731,-0.010586841,-0.026534189,0.017751282,0.055694602,-0.006311498,0.009415772,-0.033080272,0.008623962,0.028290693,-0.023563186,-0.015151777,-0.025003038,-0.010648176,-0.0048248456,-0.04484857,0.027018646,0.027279984,-0.019780928,-0.005493245,0.06685515,-0.094037965,-0.050458923,0.02068568,-0.050012305,-1.9500755e-33,0.02438736,-0.10834702,0.02696604,-0.028353365,-0.04536275,0.03044566,-0.007774396,0.027665202,-0.002230934,0.102096006,0.12848917,-0.05426296,0.0019478004,-0.008817773,-0.03743569,-0.023637759,-0.010761991,0.054722976,-0.0021453444,0.079394735,-0.011205742,0.049593445,0.011176103,-0.013385566,-0.0008798938,0.02068597,0.00986427,0.07094772,-0.0118741505,0.019605689,0.014698125,-0.0019205804,-0.09735934,-0.07046554,-0.0018449177,0.049573917,0.04674047,-0.057832237,0.06317038,0.030541405,0.036707047,0.016639136,0.012800921,0.03954437,0.044907946,0.053781684,-0.11749453,0.015397695,-0.060385462,0.020658132,0.033398718,0.025301555,0.03515669,0.06629409,-0.015980616,-0.02452576,-0.0093080085,0.06291485,0.027146101,-0.061722703,-0.011187372,-0.05973402,-0.03143499,0.10059455,-0.015547308,0.09507579,-0.08828415,0.058111224,-0.036314845,-0.0076416056,0.009146378,-0.00448275,0.059317585,0.09420879,0.011822982,-0.03486335,0.0072461735,-0.08968027,0.033557717,0.027063148,0.01630098,0.017104339,-0.041687157,-0.08466815,0.027955214,-0.018261468,-0.012777541,0.11180842,-0.032390974,-0.054237038,0.0038135867,0.06609076,-0.09262165,0.040480293,0.051565614,-2.8027522e-08,-0.022694765,-0.036365796,0.06218233,-0.036726583,-0.006191498,-0.00024724932,0.013020699,0.04897192,0.019937573,-0.040390767,0.011319771,0.06872067,-0.047867224,-0.008879239,0.015900435,-0.020601068,0.034408372,0.062810615,0.033138458,-0.013933778,-0.0076106493,-0.007963484,-0.019588001,-0.01632878,0.033726472,-0.14010668,0.060340602,-0.019380443,0.02062991,-0.040927164,-0.0036946204,0.044480458,0.008098889,-0.036354933,-0.021817505,0.044300515,-0.07726011,-0.053178858,-0.010594873,-0.059561875,0.00057812297,-0.027625471,-0.08845292,-0.07413284,0.064581655,-0.03325984,0.08156833,0.07780214,-0.027365478,-0.017805507,-0.029181672,-0.025806153,0.0841497,-0.1231032,-0.11310825,-0.08906431,0.060399428,-0.007885302,-0.010268574,-0.08774906,-0.008047026,-0.0033898267,0.15736863,-0.020030687 +1.14.14.115,A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plant Glycyrrhiza uralensis (licorice) is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin. The enzyme from the plant Medicago truncatula can also hydroxylate beta-amyrin.,384,1.0,-0.07317324,0.015746353,-0.08894423,0.018092938,-0.002374449,0.07484371,-0.03579496,0.058017224,0.01804179,-0.037548203,0.055139225,0.032459207,-0.070051715,-0.027637266,-0.06295548,-0.0002571909,-0.07093275,0.0339715,-0.011976979,-0.038088217,0.031219168,0.05710014,-0.012781139,0.01200673,0.041542288,-0.027742023,0.0032515223,0.05736487,0.02772848,-0.05090171,-0.024575576,-0.021867953,0.029720873,0.028998004,-0.0036424813,0.1091421,-0.05374689,-0.09332406,0.071900465,-0.009798851,0.12570164,-0.0070123165,-0.03264307,-0.006265428,-0.0067928457,-0.013164416,-0.024839804,0.013230677,0.01135151,-0.03970409,-0.026570477,-0.05251727,-0.03744586,0.040563088,-0.01068208,-0.021444684,0.06164441,-0.00805633,-0.0017834889,0.033443082,-0.021891074,0.09050363,-0.006312945,-0.0025776017,-0.044889465,-0.072068304,-0.07208981,0.016152028,0.010553118,-0.05113853,-0.024677094,-0.084963456,-0.052176185,-0.023020217,-0.11773459,0.060739715,-0.055472944,0.042075574,-0.025349196,-0.042841125,0.06289861,-0.016852973,0.043692313,0.16226125,-0.00015178224,-0.04518203,0.0052733356,0.070568234,-9.2962755e-06,0.025331052,0.084534995,0.0059691174,-0.0068097757,-0.02206,-0.10416894,0.060682178,0.06612251,-0.08686247,-0.043538053,-0.004754811,0.022272788,0.04184324,0.048750427,-0.13953161,-0.06983353,0.06314491,-0.020984782,0.005720814,0.11835664,-0.07853355,-0.07861067,0.0060937833,-0.02004951,-0.001185764,-0.0170014,0.059210096,-0.011621759,-0.050875567,0.03178111,-0.034503497,-0.0044305166,-0.016888041,0.019680008,0.02715884,0.00027325557,0.03566662,-0.092723384,4.8711964e-33,0.11366162,0.06686863,-0.018122092,-0.043921355,-0.008727072,-0.0049225935,-0.06289094,0.023977881,-0.055416666,-0.050652422,-0.09639501,-0.07855708,-0.016369151,-0.018890927,-0.018268086,0.04770549,-0.09595216,0.038611684,0.109128,0.03381195,-0.023453062,-0.05322179,-0.09556441,-0.06306887,0.045780156,0.10695951,-0.0080356635,4.638793e-05,0.040305395,-0.0019210965,0.019393567,-0.059931368,-0.060109816,-0.008016318,0.07993115,-0.038841814,-0.025571141,-0.028258955,-0.06376097,0.0410644,0.016928075,-0.020216584,0.0091349585,-0.032952204,0.08329088,0.04004674,-0.08094731,0.022845346,0.03327455,0.07346401,0.0675075,-0.05744267,0.10025444,0.04980143,-0.074343584,0.044552945,0.020541511,0.027198961,0.010878547,0.05312909,0.091288514,0.03773357,-0.0029850537,-0.0018466167,0.053600214,0.08922724,-0.0700446,-0.047603324,-0.011076789,0.07925973,-0.04519189,-0.08230446,0.06248417,-0.019076291,0.00896712,-0.002237101,-0.038080394,0.005828182,0.005091138,0.035914406,-0.034703277,-0.03872755,-0.0015672367,-0.051308513,-0.025994299,-0.00022969293,0.022079729,-0.017949723,-0.050725434,0.0022444506,0.10173105,-0.032532297,0.0066126557,-0.0047621024,-0.030960029,-5.0282998e-33,0.062414497,-0.08542402,0.04575585,-0.080262624,-0.023061037,0.018863065,-0.020809416,-0.08029051,0.018914994,0.061855443,0.06565517,-0.06330091,0.019659888,-0.019265184,-0.006817843,0.004051033,0.0055185594,0.07894949,0.0006609548,-0.0002524053,0.008086541,0.022083433,0.0026323004,0.030907096,0.008331115,0.013044918,0.049154714,0.022620419,0.022820815,0.011584438,-0.015416773,0.020802226,-0.06950583,-0.05301575,-0.045051683,0.08932987,-0.04935804,-0.0058443355,0.037447575,0.021653604,0.012835631,0.042727575,0.031615872,0.099351175,0.08350212,0.022274682,-0.08255693,-0.026178727,-0.030271007,0.028354501,0.06915984,0.021543369,0.032612126,0.0741369,-0.025095457,0.013136508,-0.02272043,0.027465396,-0.056899067,-0.05791334,-0.011035568,-0.063939326,-0.050168566,0.03371996,-0.0015849934,0.053694047,-0.010933785,0.061490197,0.03031128,-0.0012305571,0.04857363,0.013894088,0.088459976,0.11526576,-0.020650337,0.041119684,0.008553407,-0.068583235,-0.0069065285,-0.029562142,0.017315205,0.045861818,-0.058626343,-0.06069833,-0.06421742,-0.07272351,-0.033904426,0.14580986,0.019999899,-0.014106625,-0.01748893,0.085855566,-0.05104905,0.050343864,0.029796502,-3.8093656e-08,-0.009839008,-0.10021058,0.0038592399,-0.024956921,0.033348408,-0.016527245,0.003362803,0.012854125,0.02002418,-0.0130754225,-0.021939423,0.06676932,-0.057025947,-0.013296138,0.01710187,0.026140712,0.020557888,0.03548122,0.011485388,0.034181446,-0.029706601,0.028084856,-0.08681413,0.045856956,0.017650926,-0.12857777,-0.010497263,0.02224916,0.00720891,0.0072802366,0.069261335,0.06472552,-0.05459833,-0.0223774,-0.0007279848,0.0613458,-0.06009397,-0.08338155,0.01296555,-0.042270828,-0.0123124365,-0.028957509,-0.047665123,-0.047897454,-0.023895124,-0.013306296,0.046564657,0.0003507666,0.023612563,0.0025919522,-0.00823575,-0.030913947,0.0006474324,-0.1120086,-0.07326465,-0.015711756,0.045312483,-0.021500831,-0.052065093,-0.055328656,-0.04181204,0.03315068,0.23199983,0.020428762 +1.14.14.116,A cytochrome P-450 (heme-thiolate) protein isolated from the saprophytic mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis. Does not react with (1'R)-averantin.,384,1.0,-0.02065827,0.048561323,-0.08126371,0.020949524,0.08143879,0.026787035,-0.05163632,0.112346716,-0.014092239,-0.05586762,0.019060789,-0.041694526,-0.04646551,0.076242946,-0.096121594,-0.015562196,-0.01637665,0.0049181636,0.0089047225,-0.055585455,-0.017228378,0.08078037,-0.0018468251,0.020398997,-0.0039682793,-0.024593966,0.04811827,0.08945959,-0.047354694,-0.05364066,-0.08678752,-0.058583647,0.015715854,-0.04111613,0.038554415,0.073676884,-0.029425101,-0.022618402,0.06888691,-0.06185043,0.043353114,-0.04225182,-0.05308836,0.003605437,-0.079136305,-0.037088852,-0.051391505,0.0060963463,0.039560605,-0.032649532,-0.043903213,-0.0015044446,-0.016670654,0.043725606,0.06492379,-0.011590169,0.02723437,-0.060540162,-0.06835571,-0.0534356,-0.041281246,0.01520503,-0.02536211,0.020491133,-0.070301235,-0.0031173343,-0.011982797,0.0010134116,-0.04729794,-0.037317432,0.005545433,-0.07424521,0.011673805,-0.007904724,0.037572015,0.09237577,-0.047654804,-0.003913969,0.052222557,-0.014526625,0.08979088,0.013708137,0.01457395,0.11355159,0.036280468,-0.057757244,-0.03458896,0.076342784,-0.053326283,0.033195626,0.035029422,0.06262205,0.025457652,0.0052083093,-0.0622021,0.03375213,0.061626356,0.03719537,-0.027944857,-0.0058016707,-0.00047248165,0.030777428,-0.019901676,-0.028065955,-0.0054761865,-0.024571368,-0.016062649,0.03672727,0.1016334,-0.060797,-0.01551885,-0.027212532,-0.017420335,-0.060059115,0.0034757187,0.01081535,-0.0010529344,-0.019420449,-0.0014397077,-0.0030898438,-0.006718026,0.03468481,-0.014235086,0.031798385,0.054143764,-0.03275007,-0.09216656,3.2603004e-33,0.05889223,0.06399514,-0.07257992,0.0019979195,0.052171227,-0.034437343,-0.025784304,0.02304111,0.002290002,0.07155171,-0.10480625,-0.049723737,-0.08103992,-0.00017195648,0.0075227073,0.007839815,-0.036584415,-0.016913678,0.026844095,0.006099459,-0.0072394744,-0.0062454934,-0.06627994,-0.0037430525,0.025486251,0.09108353,-0.017416272,-0.039086122,0.0010481038,0.020891529,-0.007637088,-0.04399659,-0.09834426,-0.05608972,0.077211596,-0.012655133,0.014291324,-0.014195819,-0.11766071,-0.0031885325,-0.011263873,0.010112412,0.00451263,-0.122352205,0.0678027,-0.014627379,-0.1457544,0.061016627,0.04492247,0.041534998,0.1308795,-0.04418018,0.095531195,0.059734326,-0.04033074,-0.033341277,-0.07136917,0.048390057,0.02640702,0.03913307,0.10934507,-0.0015995462,-0.024430724,0.06797394,0.026176278,0.035950255,-0.01166503,-0.063615985,-0.04001737,0.07335968,-0.0029572132,-0.008448705,-0.01671068,-0.025929788,-0.01821409,-0.006814842,-0.031300887,0.037162658,0.05099935,0.023556666,0.029881645,-0.02674861,-0.024534356,-0.04081765,-0.069288366,0.015308409,0.057574507,0.04585905,0.019846424,0.044818554,0.0574487,-0.07209028,-0.033749364,0.060725246,-0.019631095,-4.1417827e-33,0.079539366,-0.09750995,0.06494034,-0.090370685,-0.09522304,0.07049609,-0.004763099,0.050091226,0.018169211,-0.014063892,0.09916773,-0.0192591,-0.003621693,0.019575967,-0.013525512,0.03440042,-0.049272098,0.054570384,0.059869587,0.048899334,-0.062466297,-0.00913928,-0.023479557,0.041317143,0.035604887,0.06251782,0.023213042,0.057149213,0.02325641,-0.0038482298,-0.048247974,0.09476811,-0.023171816,-0.06696772,-0.08700238,0.08641591,0.026155312,0.020265436,0.013570057,0.06782402,-0.014398518,0.0648924,-0.037863437,0.07021256,0.048343558,0.08492995,-0.039530292,-0.045750536,0.06515934,-0.05184937,0.04913739,0.021758834,0.003688106,-0.014956194,-0.04903883,-0.018150004,0.019796722,-0.016238445,0.041210078,-0.062195852,-0.031420816,-0.017954491,-0.054425247,0.05569688,0.056167945,0.08265676,-0.066727065,-0.023871522,0.054608773,-0.034427237,0.040912356,0.004109349,0.036906466,0.063555524,0.021436803,-0.0066253506,0.033370744,0.012201162,0.0647974,0.051029775,0.018622957,0.022320047,-0.009446585,0.0032387732,-0.09154486,-0.12581082,0.031538807,0.10881429,-0.07670078,-0.05044795,0.00092088606,0.12706217,-0.0014897324,0.03823772,0.084664464,-3.415903e-08,0.025250703,-0.03070678,-0.0082128495,-0.055418108,0.023668595,0.0027056308,0.033783413,-0.04181735,0.031823784,-0.038094703,-0.0693249,0.05928087,-0.04539081,0.007382178,0.014355915,0.013683806,-0.032919172,-0.008695888,0.037691712,0.013382197,-0.058985412,0.039260063,-0.05353599,-0.041809585,-0.019669736,-0.06005838,0.02770393,-0.016424743,0.06777486,0.037863716,-0.0336325,0.08376886,-0.026387496,-0.047630135,-0.045461077,-0.0048687006,-0.07503194,-0.12057462,-0.020914862,-0.074808985,-0.040249493,-0.06539572,-0.048279442,-0.101135984,-0.024958948,-0.059951108,0.0406172,0.02455604,-0.015779559,-0.053502057,0.04928499,0.005825221,0.025427781,-0.097286664,-0.07895866,-0.02137879,0.092972316,-0.018656444,-0.051837664,-0.11083258,-0.0060280296,-0.040513992,0.17460006,-0.010688017 +1.14.14.117,A cytochrome P-450 (heme-thiolate) protein. Isolated from the mold Aspergillus parasiticus.,384,0.99999994,-0.064286865,0.07732863,-0.06868287,-0.031047713,0.037320804,0.027040355,-0.05316224,0.11797068,-0.020189753,-0.04888691,0.042358097,-0.041943595,-0.01719275,0.05179014,-0.08146572,-0.0271425,0.049565144,-0.001896522,0.016034983,-0.07347388,-0.004342594,0.10542776,0.0143437395,0.020272538,-0.004539324,0.0150743,0.08481229,0.04837928,-0.060212143,-0.07030511,-0.105546154,-0.033799823,0.008889033,-0.043394618,0.04619703,0.08626992,-0.06964934,-0.0139224995,0.082477145,-0.046581704,0.058358442,-0.024422044,-0.05754022,0.013130196,-0.08582697,-0.016315512,-0.047059815,0.04169465,0.050787274,-0.04113753,-0.012059739,-0.020165978,0.011869219,0.030500585,0.0014767976,0.001833616,0.033587083,-0.041651532,-0.05576696,-0.038127873,-0.053050403,0.040171888,-0.022281317,0.007058205,-0.04873862,0.0005110352,-0.00059716555,0.012410994,-0.06824571,-0.045277994,-0.0022754294,-0.041246224,0.04699802,-0.0049393526,0.010500972,0.06637007,-0.01326373,-0.03307964,0.04536589,0.01687755,0.056587107,0.0481975,0.0043132245,0.059020992,0.012493708,-0.02606751,-0.009768735,0.1063542,-0.056871925,-0.030784544,0.003294474,0.07320138,0.0028405057,0.0014887385,-0.086769,0.05832615,0.04736778,0.086162806,0.0071921423,-0.023646649,0.053818867,0.004836982,0.041492086,-0.06436547,0.00026805507,-0.011289307,0.011264077,0.058957566,0.12629284,-0.07425138,-0.031317502,-0.036267478,0.0015950997,-0.10049956,0.033930372,0.0052918093,0.032664225,0.020603335,-0.011633114,-0.02422978,-0.008803033,0.025376914,-0.0021835226,-0.042857587,0.0097464565,0.0056323586,-0.09350247,-1.28454735e-33,0.037698712,0.043425698,-0.0316237,0.029207367,0.022539614,-0.013581832,-0.00712693,0.047987476,-0.026420804,0.028381815,-0.09768616,-0.06287101,-0.088662066,-0.0031995068,-0.0244634,0.025090616,-0.005075387,0.027723128,0.0016130038,0.014931082,-0.019245997,0.0028944837,-0.053284917,0.008823533,0.039563254,0.093830496,-0.018504696,-0.04447364,0.0017289497,-0.009014977,-0.009723483,-0.056680508,-0.09722018,-0.042519916,0.069680884,0.002622789,0.034132645,0.0028386891,-0.09949056,-0.035623275,-0.01549484,-0.011255026,0.023411937,-0.114664555,0.044755045,-0.018277705,-0.12901787,0.02288344,-0.010392125,0.011191459,0.11429131,-0.043279644,0.089482464,0.08348216,-0.03713141,-0.01732945,-0.021895217,0.056018207,0.025161333,0.052987754,0.09694632,0.067010544,-0.06103285,0.09148403,0.025888782,0.007579398,-0.06069934,-0.0057235155,-0.03382274,0.074788064,-0.007509652,0.006410273,-0.014062638,-0.05527091,-0.009032228,-0.042473078,-0.02239886,-0.002785625,0.036841884,0.031943306,0.048607904,-0.017813947,0.008499126,-0.049303595,-0.083812326,0.030613145,0.096939035,0.038593117,-0.003588337,0.05920827,0.017509265,-0.09501798,-0.02175107,0.034799073,-0.01005493,-2.9410855e-34,0.1220305,-0.07977744,0.04508726,-0.07756576,-0.07796286,0.07645734,0.039592687,0.029190361,-0.049613096,-0.04403445,0.09943774,-0.008255577,0.009259154,0.03327637,0.0056187105,0.042028125,-0.044997666,0.07225983,0.044659894,0.03391641,-0.072127685,0.007654296,0.0068504135,0.013759795,0.024859056,0.035244122,0.021537332,0.060479213,0.0033848272,0.0099476,-0.043058913,0.08886009,-0.018854005,-0.042270128,-0.08145672,0.08037793,0.022211395,-0.034680054,0.048308555,0.037725314,-0.054956995,0.034809727,-0.012299772,0.07589029,0.023981417,0.12562995,0.00080632925,-0.028739184,-0.0028390053,-0.039723273,0.056194052,0.009274755,-0.045466766,-0.017968679,-0.07209974,-0.013566425,-0.042742793,-0.0048053744,0.060034618,-0.06118231,-0.034032308,-0.007895256,-0.06416319,0.08351987,0.022227475,0.058738336,-0.052611373,-0.045209527,0.07222738,-0.03357267,0.0010911764,0.039729733,0.019079829,0.07898387,0.033638682,-0.011324629,0.028171811,0.018430026,0.06915686,0.022328805,0.018391512,-0.03411743,-0.010667907,-0.014707843,-0.024101637,-0.12699229,0.027881932,0.08379274,-0.065771796,-0.05554773,-0.025419498,0.115079425,-0.03974557,0.0608357,0.08079789,-2.3997574e-08,0.059997424,0.002292863,0.0007395047,-0.093250565,0.006231895,-0.0022388503,0.063524365,-0.025867138,0.07829235,0.0017713609,-0.05966653,0.012965493,-0.073971875,0.027453007,0.02969575,-0.0017703127,-0.03600519,0.007966529,0.049971867,0.027873967,-0.030362511,0.02804469,-0.046261426,-0.006241007,0.015699137,-0.057170767,0.056785095,-0.03990053,0.0728997,0.026308527,-0.03179355,0.061501663,-0.05769315,-0.035402436,0.048488535,0.026201818,-0.09740856,-0.053695876,-0.0161198,-0.023546454,-0.01354181,-0.07419742,-0.0908271,-0.09011582,-0.059774593,-0.07522388,0.04845922,0.06391201,-0.03649304,-0.049881358,-0.00791649,-0.005032373,0.031932067,-0.1006763,-0.09187122,-0.026894314,0.12633052,-0.022629455,-0.090907164,-0.10489564,-0.022050012,-0.026350925,0.12835042,-0.0008324446 +1.14.14.118,"A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.",384,0.99999994,-0.01865493,0.0039551375,-0.01062954,-0.0017098245,-0.013934812,0.12436698,-0.021527402,0.08885201,0.04446468,0.013517068,-0.034957014,-0.062983915,-0.020209124,0.06745889,-0.04006353,0.02965123,-0.040496685,0.03566076,0.0041303714,-0.09920114,-0.061243705,0.06939817,0.09696333,-0.028820584,-0.019229593,0.024004662,-0.020758696,0.07735253,-0.013181567,-0.02246986,-0.025957333,-0.03093654,-0.047369864,0.006114197,-0.0050937627,0.090624966,-0.13467991,0.00875792,0.06588785,-0.025324335,0.023006188,-0.043464117,-0.13319838,0.068299174,-0.021385023,-0.014896981,-0.020145003,-0.0035004446,0.041448142,0.014488719,0.0012268273,0.004372662,-0.018799005,0.054976657,0.044722397,-0.0059328596,0.06150992,0.06340106,-0.003685013,0.014238878,-0.004905089,0.057783473,-0.01577581,-0.01771484,-0.0035750307,-0.040792413,-0.048179068,0.010799519,-0.0035062712,-0.034662973,0.008922219,-0.081249736,-0.011985686,0.035777334,-0.06279622,0.09526171,-0.05030321,-0.024511637,-0.10325155,-0.05284556,0.07929005,-0.0029503985,0.008553425,0.119615674,-0.012857624,-0.027964309,-0.025755987,0.054044608,-0.038259707,-0.02159169,0.022302931,0.029152488,-0.02467133,-0.04566478,-0.028590227,0.021686576,0.0028424994,-0.00065547094,-0.0045395126,-0.032261584,0.060154684,0.012980204,-0.049615804,-0.10331671,-0.0059512258,-0.028453333,-0.034175735,-0.0051443544,0.068867475,-0.07672315,-0.037156846,-0.030498674,0.07601607,-0.00800172,-0.003517835,0.0657397,-0.038745224,-0.01649848,0.0055192453,-0.020942908,-0.03436527,0.0074167126,0.02943154,0.07843999,-0.060958933,-0.040720254,-0.072930284,2.0204487e-33,0.12331765,0.01371146,-0.014195876,0.09001467,-0.0026952936,-0.034086023,-0.064977184,0.0029233973,-0.017064014,0.014858725,-0.079225264,-0.0678371,0.030473303,-0.023880351,0.009893589,-0.0031181048,-0.10334495,0.0059616724,0.028760223,-0.044619072,-0.10567098,0.0036937392,-0.032762036,-0.029603709,-0.061026298,0.10782875,-0.0094867945,0.027644565,0.012803686,-0.022896819,-0.055016335,-0.02050574,-0.041069496,-0.049015976,-0.016702158,-0.035473548,0.025197184,0.014954256,-0.097618386,-0.0010391051,0.01384474,0.052443072,-0.013355527,-0.025454199,0.07717189,0.022985213,-0.10470438,0.08078545,0.013003058,0.08877064,0.07937682,-0.09567508,0.10726947,0.058490034,-0.07834053,0.011893367,-0.0059296633,0.00627798,-0.023992518,0.083811335,0.041199908,-0.009507536,-0.03073161,0.038797535,0.026566269,0.021430874,-0.005933371,-0.100464195,-0.028758572,0.1251262,-0.058274236,0.024674874,0.069378175,-0.027397968,0.008364438,0.015578315,0.0035547388,0.042624537,-0.011706418,0.047446035,0.023617666,-0.047828082,-0.031108899,0.0023455746,0.039694205,-0.07086041,0.031177785,-0.0591064,-0.0060779504,0.021222053,0.017313423,-0.089943245,-0.033002257,0.08343326,-0.030117301,-3.1523864e-33,0.049033005,-0.09115766,0.02931779,-0.056216612,-0.04681114,0.0572567,-0.007487296,-0.0059612715,-0.012689604,0.039119355,0.14579281,-0.075383015,0.0905028,0.035224143,-0.046935156,-0.094070375,-0.026285244,0.047637407,-0.0053344844,0.111080326,-0.03260059,-0.016498856,-0.00805234,0.043440953,0.048661992,0.106009424,-0.003471548,-0.005396554,-0.056179494,0.014254292,0.045622718,0.010745822,-0.14583905,-0.039738342,0.028717538,0.036820687,0.038194228,0.008897918,0.008334344,0.01926531,-0.00087009784,0.11253715,0.040659904,0.042905163,0.015961006,0.06448815,-0.07107083,-0.015803937,-0.01173656,-0.0783431,0.04356172,-0.008135433,-0.023517255,0.02452232,-0.033328693,-0.0067637153,-0.022433452,-0.0027799488,0.025570374,-0.028906161,-0.04804706,-0.035041384,0.03683718,0.020702375,-0.059639387,0.05735549,-0.016348023,0.023446796,0.066930465,-0.012872001,0.025282072,-0.02394327,0.07919376,0.10920322,-0.022476656,-0.043955095,0.018692758,-0.053318217,0.07994905,0.038173135,0.017556615,0.07386198,-0.058886163,-0.046691086,0.031202627,-0.020256829,-0.07652588,0.12566407,0.06299981,-0.055786405,0.006443117,0.063875034,-0.020582674,0.07082236,0.026901316,-3.139661e-08,0.010708218,-0.083578095,0.023214994,0.014771122,0.01818917,0.0037474027,0.014978022,0.012607073,-0.0070159156,-0.065478496,0.026635826,0.042551924,-0.10138105,0.0077385893,0.014860719,0.0031993708,0.026614474,0.049647383,0.049377058,-0.018272575,-0.07387009,0.031834953,0.008586756,-0.0056938445,0.046315156,-0.082881205,0.018568007,-0.041436937,0.052011263,-0.039249964,0.041387215,0.012234016,-0.016435523,-0.009079068,0.021177454,0.03723277,-0.014403962,-0.0037279378,-0.036134224,-0.03341849,-0.014207282,-0.054621287,-0.0692349,-0.04371335,-0.037222456,-0.042880964,0.06363735,0.06956256,0.006589219,-0.057108942,-0.03982064,-0.010673278,0.00936556,-0.09179411,-0.13647889,-0.040476076,0.028846715,-0.024675129,-0.031041214,-0.13904952,0.011481218,-0.009272176,0.15169413,-0.017986925 +1.14.14.119,A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the indole alkaloid verruculogen.,384,0.99999994,-0.041627076,-0.011041581,-0.0136029245,-0.016138887,-0.046506234,0.11742837,-0.0540647,0.077837184,0.039007455,0.015918203,-0.025537254,-0.031745356,0.025408026,0.03353422,-0.014904435,0.023891756,-0.038597085,0.031977993,-0.012626265,-0.1159469,-0.022968221,0.06997657,0.09754833,-0.019394895,0.04836216,0.013747751,-0.004260839,0.08347428,-0.034689758,-0.038466163,0.015345743,-0.011105953,0.019062812,-0.03585579,0.006918279,0.06632926,-0.11224545,0.01963618,0.06818989,-0.024862515,0.044942163,-0.049809437,-0.12539335,0.0677569,-0.022054428,-0.010448876,-0.018204035,0.0060524587,0.028065342,-0.012214583,0.025642501,-0.012078047,-0.04338851,0.06100449,-0.012974632,-0.046748284,0.07202203,0.05999236,-0.0045506638,0.006965691,-0.015392194,0.076745756,-0.002721305,0.023296973,-0.03930463,-0.04105775,-0.031690102,-0.009580202,-0.004721862,-0.023259116,-0.002607327,-0.11968522,-0.03857419,0.030309942,-0.08549293,0.05056931,-0.032578427,-0.0270462,-0.093743585,-0.027898284,0.0939074,0.054099735,0.017106486,0.11674202,-0.033709228,-0.014388594,0.0031724118,0.014586652,-0.054694284,-0.040874586,0.028887857,0.009040974,-0.02505892,-0.037646834,-0.03557239,0.05971252,0.047012135,0.0047072894,-0.00016520798,-0.03743589,0.08339965,0.04012796,-0.036143653,-0.053216737,-0.036659427,-0.030246645,-0.008008896,-0.00023713999,-0.0032032852,-0.08215495,-0.0021364791,-0.025687356,0.042092413,-0.0040898984,-0.024046658,0.06562264,-0.028289894,-0.025364628,0.0127110565,-0.029928684,-0.07181726,-0.016969193,0.0024399976,0.05054816,-0.029963965,-0.046253096,-0.07145258,2.3819246e-34,0.10126975,0.029317195,-0.024458446,0.018925294,0.024430526,-0.028698545,-0.07136836,0.04245691,-0.012713592,0.033772036,-0.06143698,-0.0733388,0.030059025,-0.021541532,-0.017483452,0.05123868,-0.1375021,0.006160824,0.01951131,-0.038009245,-0.0867443,-0.010855083,-0.06101311,-0.0036536308,-0.09224547,0.11990557,0.023731837,-0.0061856387,0.0032210755,-0.013649643,-0.00978936,0.0037778206,-0.053786036,-0.03864227,-0.054040216,-0.030564288,-0.013614723,0.033341493,-0.06422475,0.050785616,0.03682991,0.052342243,0.025242755,-0.02850592,0.09202482,0.008234594,-0.13187057,0.091986105,-0.0031131685,0.113204755,0.07853614,-0.0491176,0.13395886,0.0548425,-0.06516081,0.04260137,0.001751272,0.0057519977,-0.04909344,0.06738683,0.03932159,0.011965233,0.015167263,0.025434744,0.031956997,0.02297597,-0.028651042,-0.10105875,-0.017932098,0.10823793,-0.058481812,0.01930574,0.06484442,-0.01609469,-0.004456722,0.0019145434,0.006312826,0.06382321,0.023475166,0.054302186,0.0009505456,-0.021245427,0.026844017,-0.01475383,0.07846186,-0.06382495,0.025008412,-0.06868043,-0.018612538,0.06877295,0.05520578,-0.07767848,-0.05684783,0.08284089,-0.028489107,-1.5267044e-33,0.084977075,-0.077385984,0.004470041,-0.053787116,-0.041559104,0.023626074,-0.044821188,0.04100508,-0.005411888,0.07881141,0.13901125,-0.02804711,0.07017969,0.048444886,0.015522311,-0.09449626,-0.015625695,0.088457055,-0.043069676,0.11285009,-0.056621682,-0.018152678,0.013089811,-0.006585875,0.07578691,0.050588243,0.027586687,-0.0006228938,-0.06283496,0.005688042,0.03671315,0.024037404,-0.13556047,-0.018844089,0.014428192,0.034364596,0.0030816495,-0.006694523,-0.015258854,0.046172097,-0.021939663,0.10235599,0.01565633,0.017474277,0.036009114,0.0393755,-0.06790065,0.0020561786,0.027600175,-0.082357086,0.056003943,-0.006756051,0.015034278,0.011842784,-0.02109831,0.018496215,-0.026937736,0.018725969,0.0035962209,-0.0513073,-0.0487873,-0.001834609,0.027651604,0.012859294,-0.04205018,0.05236017,-0.022157554,0.03275235,0.048904687,-0.03007275,0.010798995,-0.012572225,0.048716873,0.06439192,-0.018921094,-0.03517197,0.021027768,-0.04745412,0.049251538,0.012141016,0.030316629,0.07402706,-0.057885814,-0.08502356,0.022480253,-0.03677463,-0.07258061,0.1667032,0.052721877,-0.05771281,0.039925713,0.069938086,-0.05673159,0.06550227,0.07561181,-2.7338691e-08,0.012315962,-0.040569324,-0.018455785,0.041035235,0.04731,0.023208156,0.014157312,-0.0017052481,0.009323152,-0.050006054,0.039272185,0.021953078,-0.0949823,0.019809607,0.020853084,-0.00025598175,-0.005895359,0.024257055,0.036073226,0.0059400327,-0.056506433,0.008021979,-0.00021816885,0.027766354,0.051472206,-0.08643274,0.041697413,-0.06771254,0.059332356,-0.039282124,0.03920951,0.025622679,-0.059698038,-0.004393614,0.032150883,-0.017142486,-0.024491724,-0.032539085,-0.023532609,-0.041657932,-0.008877482,-0.07317163,-0.08493823,-0.040171627,-0.022102488,-0.035414394,0.026774243,0.058108293,-0.03035752,-0.046478342,-0.046569694,-0.042060606,0.034643296,-0.12115664,-0.12266261,-0.040150773,0.013524038,-0.029829547,-0.03877605,-0.10519985,0.010054446,-0.018975213,0.15408319,-0.030804573 +1.14.14.120,A cytochrome P-450 (heme-thiolate) protein isolated from ginseng (Panax ginseng). Involved in the biosynthetic pathway of ginsenosides.,384,0.99999994,-0.08329343,0.0101431655,-0.038647335,-0.011090055,0.024762774,0.04789237,-0.010079616,0.13412333,0.053323586,0.057595413,-0.06674355,0.06549745,-0.004410855,0.059022155,-0.02607666,-0.0004058786,-0.07346433,0.034792874,-0.01612753,-0.044912633,0.03884076,0.031261932,0.068410516,0.022009306,0.058219705,0.016191922,0.07307031,0.013468123,-0.028521558,0.07623596,-0.057163503,0.00027764443,0.015446992,-0.06712248,-0.008419982,0.07721046,-0.068957455,-0.07738498,0.07023106,-0.0787831,0.117048256,0.059017062,-0.022255082,0.020615868,0.051373754,-0.0072738663,-0.033631917,0.017191702,0.03539463,0.05380001,0.02425586,-0.02992038,0.021007564,-0.015828572,-0.008980308,-0.02944224,0.004655892,-0.031094478,0.05174182,0.053305604,0.017345803,0.03026058,-0.083679944,0.068730325,-0.014836752,-0.029568803,0.02444099,0.099667154,-0.017421747,-0.054561693,-0.010611276,-0.068249926,0.030944424,0.030794607,-0.002941166,0.023386445,0.010129904,0.044344634,-0.059579507,-0.021693155,0.036232214,0.010959971,0.018758046,0.16803713,0.014271525,0.0042980546,0.004241089,0.118398815,-0.056666005,-0.06895717,-0.03602692,0.015710926,-0.021146324,0.01222142,-0.005203088,0.0019837557,0.017405223,0.03239868,-0.011883548,-0.01978,0.043109726,0.08865711,0.014814185,-0.119355835,-0.025170371,0.05108671,-0.06512299,0.038317066,0.0722672,-0.035906143,0.008680423,0.01654813,0.024201062,-0.042526677,-0.021863593,0.047882456,-0.03013893,-0.03170895,0.026511008,-0.0070988587,-0.018403498,-0.047687832,0.039433006,-0.014940705,-0.06693922,-0.021531645,-0.011971122,3.607821e-34,0.008156229,-0.010903084,0.06501975,0.0057632593,-0.042016782,0.059537012,-0.017010627,-0.032453675,-0.05321761,0.046616036,-0.088488184,-0.052073874,-0.03125166,-0.06647026,-0.037883334,0.023697576,-0.041959554,-0.015598905,-0.0031838943,-0.013575455,-0.04626297,0.08275461,-0.08715047,0.05792857,-0.02988273,0.059892166,-0.0005865039,-0.059635837,0.017983297,-0.0155502325,-0.06664877,0.014376179,-0.010932362,-0.06892386,0.029305967,0.0033938738,-0.037352517,-0.012835029,-0.047540616,0.005559339,-0.0055816155,-0.03000104,0.016210856,-0.053915624,0.001210657,-0.03445208,-0.15510139,0.009940378,-0.026873631,0.056989133,-0.010965799,-0.004748255,0.05489328,0.082007974,-0.10807344,-0.033706337,0.018998273,0.008485598,0.0051509603,0.0047902036,0.060888838,-0.0108141815,-0.0356779,0.060520895,0.040826064,0.12188055,-0.056458253,-0.008037434,-0.068186894,0.14039756,-0.050455432,0.017579293,-0.062055796,-0.03482782,0.007663645,-0.047057994,0.016446164,0.13634878,-0.0017774241,0.073530726,0.039875157,-0.040457252,-0.07271738,0.010475606,-0.02478704,-0.0135299815,0.050554898,0.039984297,0.0043077967,0.04271083,0.05375017,-0.037510965,-0.039536156,0.053463623,-0.06742488,-1.7257471e-33,-0.0030522982,-0.073513895,0.04824547,-0.05104225,-0.046008937,0.05797676,-0.013679598,-0.057456292,-0.055689383,-0.005673289,0.11260036,-0.022417884,0.03994114,0.021344354,-0.07125855,0.022199623,-0.013826664,0.043901727,-0.063410945,0.12821409,0.011479681,0.03872575,0.023819437,-0.027884394,0.00015266064,0.022464342,-0.0060588997,-0.027066901,0.023110788,0.07244702,0.013708011,0.06281359,-0.11775803,-0.029960498,-0.025723975,0.03202235,0.059502687,-0.052605588,-0.025667697,-0.00770346,-0.052113164,0.09481939,0.05449979,0.060779896,0.080559045,0.079883486,-0.08419678,-0.0106793875,-0.10365318,0.043869928,0.00057478313,0.053160734,0.009524607,0.019529652,-0.018634275,-0.07874675,-0.034476563,-0.04982736,0.009733963,-0.04996533,-0.031753916,-0.03484353,-0.016444743,0.036817674,0.037564367,-0.02017463,-0.098884836,0.101227805,-0.013392377,-0.018911898,0.006850148,0.012535323,0.110067494,0.048963606,0.006835356,0.03265613,-0.018686928,-0.056947395,0.015702566,0.009290992,0.029459536,0.06435204,-0.030381013,0.016929867,-0.067742206,-0.043542486,-0.030499011,0.072560996,0.057244554,-0.010719622,-0.070007354,0.08197996,-0.04991682,0.01103907,0.04550422,-2.5467656e-08,-0.034994528,-0.03935589,-0.00832546,0.007497786,-0.0410115,-0.0123787755,-0.07468306,0.022396218,-0.0031148088,-0.017158939,0.035060097,0.019154307,-0.07145216,-0.053441584,-0.048535094,0.0147595415,0.028338533,0.034391064,0.05746831,0.050067153,-0.026317531,-0.0069383695,0.02500813,0.046389952,0.039364938,-0.08455922,-0.0103156185,-0.0024455104,0.05604735,-0.045360323,0.0041214414,0.03505118,-0.056513518,0.0024197493,-0.024783876,0.04987227,-0.05822109,0.016498642,-0.05683985,-0.03951023,-0.044842046,-0.10513119,-0.09271679,-0.005651424,-0.06784031,-0.03137452,0.13336125,0.04938602,-0.0116755925,-0.018015664,-0.092377916,-0.018914973,0.02668084,-0.11626189,-0.04988267,-0.050619524,0.07610196,0.015345749,0.013319049,-0.13653177,-0.05275797,-0.03659757,0.12012088,0.034391508 +1.14.14.121,A cytochrome P-450 (heme-thiolate) protein isolated from the rhizomes of ginseng (Panax ginseng). Involved in the biosynthetic pathway of ginsenosides.,384,1.0,-0.07435096,-0.007454466,-0.065563194,-0.012039619,0.042103436,0.055004146,-0.005092273,0.14249873,0.044116125,0.06305952,-0.058574386,0.06415999,-0.008724795,0.08934512,-0.03442191,-0.0069958586,-0.07819613,0.048936687,-0.048263352,-0.0329675,0.035401244,0.04851872,0.070704594,0.024241608,0.06656647,0.026680809,0.08910701,0.010163836,-0.035269514,0.06213439,-0.03693977,-0.009364857,0.030513274,-0.083937556,-0.0033839329,0.08123033,-0.06667095,-0.06592513,0.07168804,-0.0744708,0.09431185,0.06736062,0.022119576,0.008564666,0.052220803,-0.0079167485,-0.047119014,0.02809883,0.053951863,0.032699946,0.004886206,-0.022413611,0.019743416,0.027649984,-0.013157334,-0.021967465,0.011869154,-0.04791508,0.014488889,0.049882878,0.015936578,0.017208736,-0.094981186,0.064085424,-0.040042207,-0.024654265,0.016526854,0.10663274,-0.0134234205,-0.031710558,-0.014259249,-0.06207015,0.027955497,0.01137768,0.0047025736,0.02839748,0.028720677,0.050207876,-0.0818891,-0.027728852,0.03027411,-0.0021977322,0.029054258,0.14961432,0.011771353,0.029865975,0.011804124,0.10022728,-0.022400476,-0.076009125,-0.03097893,0.03608299,-0.0007681483,0.0014297259,-0.023964072,0.00032779953,0.021284902,0.045289844,-0.0010730755,-0.017810693,0.071855105,0.069490686,0.01583745,-0.117269576,-0.029158618,0.054709874,-0.080241196,0.04566078,0.06097675,-0.042852025,0.009074395,0.018714938,0.033855032,-0.03015571,-0.026643366,0.03520071,-0.020900575,-0.022594614,0.011455355,0.00017842239,-0.016293313,-0.044001237,0.04727476,-0.06445416,-0.0435193,-0.029889364,-0.044932116,1.0634832e-33,0.003792777,0.015117245,0.045587137,0.0017491747,-0.0266094,0.082654014,-0.040500768,-0.025688788,-0.059645675,0.008332299,-0.09604525,-0.034820825,-0.041584328,-0.08570939,-0.052706316,0.045225326,-0.06161186,-0.020026,-0.007370059,-0.010468995,-0.031963672,0.07328153,-0.09862813,0.05381863,-0.03698018,0.043653842,0.018586105,-0.06528454,-0.018462863,-0.0107529275,-0.063047744,0.033317007,-0.03067874,-0.04754797,0.03449182,0.007322445,-0.041025497,-0.0170368,-0.038482755,-0.01136447,0.015759371,-0.03210203,-0.014388184,-0.038819272,0.009184274,-0.04066739,-0.16239406,0.025288064,-0.014685482,0.08580004,-0.015285486,-0.002914113,0.06458685,0.10161757,-0.11205134,-0.05198536,-0.0049841264,0.013089528,0.0297843,-0.0021130322,0.042658858,-0.014329654,-0.030400472,0.068152726,0.037457597,0.10491463,-0.036655057,-0.020144802,-0.053761985,0.13327736,-0.040443912,-0.0045015365,-0.05866951,-0.009717677,0.0096717505,-0.07259066,0.010509128,0.13345659,0.0013120326,0.0916251,0.04127619,-0.043794338,-0.09215128,0.006867779,-0.04474919,-0.009623044,0.05866046,0.039982036,-0.0041197445,0.031097345,0.08456619,-0.05032966,-0.041228145,0.045340043,-0.053537555,-1.6204032e-33,0.014784705,-0.068243735,0.036763318,-0.02909142,-0.025371201,0.012202949,0.002800497,-0.038824525,-0.054361477,-0.029785998,0.11230305,-0.0132557135,0.04139383,0.043823667,-0.04731634,0.010040204,0.018312786,0.039503604,-0.045340028,0.10407228,0.0016023566,0.024207745,0.008673107,-0.022642832,0.0047940323,0.03287776,-0.003943404,-0.012548164,-0.00017195365,0.064200506,0.02682851,0.09045446,-0.13155237,-0.053387605,-0.029377295,0.04302095,0.057930913,-0.03991315,-0.02401007,-0.007788581,-0.029910605,0.100889385,0.034965545,0.06208913,0.07745129,0.06943522,-0.09835799,0.005499471,-0.10541765,0.017725581,-0.005854898,0.04208163,0.025271803,-0.00019166016,-7.209087e-06,-0.07220801,-0.049080666,-0.042564377,0.014364605,-0.017594326,-0.030231195,-0.024029057,-0.031135097,0.0404574,0.030765759,-0.024535483,-0.07190979,0.096566446,0.008617464,0.00018689432,0.0055028517,0.030172259,0.13643904,0.055251453,-0.015538209,0.031988453,-0.025727464,-0.04616643,-0.00052711216,-0.0014462455,0.04383687,0.051298257,-0.009762432,0.021656573,-0.082438216,-0.062784806,-0.040370945,0.06411501,0.045577932,-0.015544797,-0.045388736,0.08190087,-0.045313418,0.03034794,0.07282178,-2.6491167e-08,-0.006803352,-0.0621691,-0.0047726976,-0.011192575,-0.023146696,0.0075789406,-0.06291032,0.012689044,0.007202354,-0.00046259037,0.023446362,0.014727171,-0.04964469,-0.02957942,-0.051032484,0.039405253,0.029859813,0.04202375,0.043095984,0.05277372,-0.0041763633,-0.011923176,0.003615381,0.047104497,0.038747583,-0.06578534,-0.014395266,-0.0045806635,0.037649024,-0.053997405,0.0077318223,0.029491233,-0.022754421,0.027904818,-0.031784635,0.04050639,-0.049624667,0.0062523847,-0.06815057,-0.08288888,-0.034050558,-0.095592104,-0.08820331,-0.009315062,-0.095183715,-0.047904246,0.10975411,0.041635543,-0.009521976,-0.04369561,-0.08630753,-0.0047330526,0.031919047,-0.12040117,-0.052346878,-0.054319423,0.0823978,0.028860554,0.012047585,-0.12945029,-0.070937015,-0.033047665,0.10237518,0.0316511 +1.14.14.122,A cytochrome P-450 (heme-thiolate) protein. Isolated from Oryza sativa (rice). Oryzalexin E is a phytoalexin.,384,1.0,-0.082647905,0.0025649406,-0.057733037,0.036281932,0.051483434,0.09872026,-0.018659811,0.04982436,-0.006592567,-0.042334504,0.10060858,-0.014221845,0.0244229,0.07139209,-0.039358724,0.037035655,0.0034520698,0.0293588,-0.07734986,-0.06305369,-0.007024524,0.08064964,0.036803227,0.049464047,0.022496138,-0.03627794,0.009667295,0.08094754,-0.00047627205,-0.047848057,-0.06859824,-0.043147083,-0.0014265265,-0.02604775,0.017211853,0.038907874,-0.023248272,-0.081038326,0.034874283,-0.07973649,0.055126134,-0.031435672,-0.06477529,0.020065669,-0.022153273,-0.06418992,-0.043673262,-0.027249746,0.087989606,-0.06624678,-0.020012101,-0.024553934,-0.03578365,0.04820525,-0.011724246,-0.030458868,0.018688863,-0.001283976,-0.06784063,0.053195227,-0.02257942,0.044974394,0.0059910603,0.044149887,-0.02644864,0.057811476,-0.051812563,-0.012171912,0.032260705,-0.080964334,0.014568277,-0.12214043,0.013758035,0.08707942,-0.02931714,0.028658764,0.012054257,0.041090526,-0.015725741,-0.026587665,0.023897778,0.01967409,0.01159401,0.15257096,0.0067760376,-0.010664404,-0.051792298,0.12200066,-0.011589604,-0.06264568,0.04449791,0.06994486,-0.0059628207,-0.005391764,-0.008612208,0.033889238,0.010622951,-0.017713772,-0.01382748,0.01059055,0.0512595,0.060866363,-0.04712873,-0.075164154,-0.013426313,0.03405237,0.012340274,-0.018336136,0.020907985,-0.06592979,-0.017277937,-0.0821058,-0.00028023383,-0.024186583,-0.048461165,0.01712176,0.014458233,0.03828058,-0.0059982864,-0.021169282,-0.0022343514,-0.016055409,-0.012595011,0.04260248,-0.021207131,0.00030094717,-0.088174485,2.4864108e-33,0.0708555,0.046644334,0.04017332,-0.00815517,0.018613156,0.010781813,-0.037556954,0.05377362,-0.0019387994,-0.05073295,-0.11281979,-0.055333372,-0.026326427,-0.00067901856,0.03465821,-0.04652733,-0.07913454,-0.020070193,0.0653641,-0.0019255222,-0.059905455,0.03198765,-0.08603305,-0.017148184,0.016538605,0.059584804,-0.024356095,-0.07163438,-0.0038057214,-0.010052127,-0.0138431,-0.08209681,-0.114353746,-0.053035274,-0.043605786,-0.039209206,0.004428479,-0.02212009,-0.081990264,0.035135925,-0.021991646,0.0383883,0.0038927281,-0.05168418,0.061275,0.008520621,-0.13413365,0.09112362,-0.006567276,0.011671566,0.051100947,-0.056741383,0.04773789,0.026814984,-0.07648717,-0.020273546,0.029532608,0.059670355,0.012906986,0.043752298,0.0881866,0.025281267,-0.0014309336,0.04697436,0.035254,0.03548122,-0.09488997,-0.08925517,-0.020074135,0.050950024,-0.03987892,-0.036763966,0.023480983,-0.037531488,-0.009890876,-0.041751754,-0.047683235,0.038679115,0.03745624,0.05853701,0.027307827,-0.042827968,0.023013905,0.0033543592,-0.07632958,0.051735144,0.010125638,0.037962157,-0.0059428243,0.02201373,0.04574931,-0.013971662,0.0070145945,0.018972894,-0.045197714,-2.2115536e-33,0.083880335,-0.05474495,0.06077574,-0.052058388,-0.024679756,0.0038314888,-0.020716403,0.07830013,0.0691089,0.058075845,0.10068336,-0.061822504,0.069886014,-0.050152216,-0.0014013143,0.11017762,-0.035709396,0.09032415,0.008855281,0.076319486,-0.08500006,0.021768343,0.025651945,0.0061289384,0.04577502,0.07928222,0.034381196,0.022518475,-0.020447932,0.03643947,-0.009866867,-0.005848322,-0.08446777,-0.056577533,-0.01692008,0.06386564,0.022632493,-0.08344451,0.009229109,0.07497289,-0.050254416,0.12328423,0.038899902,0.033855446,0.005176274,0.06896456,-0.06299062,-0.0054259147,-0.038235907,-0.027573291,0.053348884,0.01389156,-0.008782296,0.0076179905,-0.055741034,0.01825117,0.013047891,-0.0013887638,-0.056825027,-0.0647109,0.029003182,-0.006044927,-0.057005018,0.07946399,-0.024790466,0.09154583,-0.037328165,0.02838379,-0.005332369,-0.038528964,0.031974602,-0.046081934,0.057193715,0.068772115,-0.019064669,0.055229638,0.0018642785,-0.027783861,0.028026346,0.045154274,0.012652144,-0.019550228,-0.044999633,-0.017743886,-0.0021875366,-0.03818663,-0.025657501,0.14457197,0.06303527,-0.011623205,0.024169663,0.042394493,-0.048907895,0.090350516,0.10156479,-3.0646948e-08,0.082247384,-0.11447599,0.009394911,-0.024614524,-0.011145343,-0.018467892,0.0408835,-0.013816466,0.08734909,0.0041354434,-0.02925781,0.0183278,-0.10385003,0.0037724602,-0.020118194,0.035216,0.055782456,0.071227334,0.043660983,0.0026889879,-0.015887916,-0.022184048,-0.018353997,-0.012040284,-0.012071516,-0.057388514,-0.0121042365,-0.005977112,0.09058663,-0.023378592,-0.028065648,0.010701579,-0.041769303,-0.052327763,0.007224421,0.11335723,-0.0076632705,-0.09656092,-0.021996396,-0.0075769937,-0.057271097,-0.09588224,-0.017861878,-0.067525215,0.060894758,-0.04828228,0.059848454,0.033634987,-0.0038741583,-0.073054105,0.012852746,-0.052632768,0.055300705,-0.13071746,-0.103676654,-0.01847168,0.02851709,-0.0051396135,-0.04176542,-0.091898374,-0.02669415,0.02567259,0.19450974,0.013641502 +1.14.14.123,A cytochrome P-450 (heme-thiolate) protein. Isolated from Oryza sativa (rice). Oryzalexin D is a phytoalexin.,384,1.0,-0.090069525,-0.0148132155,-0.055620275,0.022521865,0.04312164,0.08839402,-0.034725036,0.049343374,-0.0011854556,-0.032169104,0.09384249,0.011208112,0.021667426,0.0668742,-0.04249421,0.046546876,0.00704538,0.050288863,-0.07012532,-0.04404257,-0.013028376,0.09811432,0.044337887,0.0481379,0.035750046,-0.029360978,0.026658196,0.07953381,0.010197197,-0.024038034,-0.0834887,-0.036337465,-0.007503293,-0.02762721,0.037109874,0.033577535,-0.015155975,-0.058798827,0.03215597,-0.066046394,0.058022674,-0.025827734,-0.052787967,0.025097454,-0.03920564,-0.048005115,-0.065261915,-0.020371348,0.084805794,-0.058474276,-0.019383948,-0.023285067,-0.036415067,0.05833736,-0.01489669,-0.025355753,0.014867788,0.003665727,-0.06980431,0.04691789,-0.035235565,0.055278324,0.010119507,0.042667203,-0.007623579,0.05081396,-0.08166838,0.009056053,0.03758695,-0.09005878,0.01718945,-0.1153055,0.020366175,0.075283736,-0.030267557,0.008339328,0.017528107,0.010431274,-0.004788768,-0.061429482,0.035632778,0.027891558,0.027104352,0.16065745,-0.0031370954,-0.009049244,-0.050118838,0.12665415,-0.015904741,-0.06815888,0.046635818,0.07250284,-0.014677278,-0.02253438,-0.029564379,0.030992705,0.023300886,-0.008874394,-0.015053967,0.0024405466,0.05462572,0.054693796,-0.054829676,-0.089553095,-0.018051581,0.038368355,-0.0070700427,-0.024944678,0.020663409,-0.07136619,-0.011417955,-0.05365811,0.010219765,0.0029969413,-0.055363674,0.0051277056,0.026957722,0.031838734,-0.015374827,-0.04172434,-0.009313504,-0.028462194,-0.0036300381,0.043785054,-0.019882428,0.012984968,-0.08214624,2.4304042e-33,0.077344924,0.03296629,0.034321703,-0.0029377297,0.0015495968,-0.0030404672,-0.03197292,0.040463302,-0.011808704,-0.03216601,-0.12363744,-0.07929581,-0.04012766,-0.0035714644,0.03755203,-0.04092358,-0.07232089,-0.016147768,0.07107825,-0.0070100185,-0.044452395,0.0520601,-0.087423034,-0.0009868407,0.03460756,0.065669194,-0.019385068,-0.055603072,0.0023900818,-0.009288864,-0.023818646,-0.08032077,-0.103263736,-0.056480825,-0.053276803,-0.026417231,-0.011159287,-0.019170923,-0.09817028,0.03426216,-0.024807308,0.013240877,-0.0040626056,-0.05376738,0.052860104,0.022085985,-0.13724154,0.103981525,-0.020139331,0.022946674,0.041528795,-0.05159675,0.039835453,0.02149885,-0.07846722,-0.035964582,0.022646371,0.040607978,0.01222691,0.05836495,0.08241046,0.015211265,-0.012108737,0.06940198,0.036308795,0.0124765495,-0.09223075,-0.085912265,-0.020006422,0.053020127,-0.04288275,-0.035527807,0.016237961,-0.03892408,-0.0037915243,-0.056595776,-0.02513223,0.02849706,0.03966802,0.03566517,0.031822603,-0.043680128,0.014140412,-0.0010253974,-0.07179356,0.04886331,0.0063685062,0.018891033,-0.025178429,0.015871959,0.024876727,-0.014855622,0.003749871,0.024750466,-0.04103747,-2.2531573e-33,0.062062122,-0.051790193,0.065084755,-0.056005508,-0.03293932,0.011700426,-0.018982593,0.09131516,0.071082465,0.040039606,0.095908165,-0.058342364,0.035992004,-0.04024937,-0.015734334,0.11933382,-0.03767796,0.076960154,-0.007740179,0.07867173,-0.09370624,0.028207917,0.016472219,0.013868003,0.0511214,0.08242719,0.032448977,0.029291786,-0.01625648,0.06415787,0.010493467,0.014999649,-0.07851699,-0.050026,-0.017296739,0.07100308,0.01702629,-0.080638915,-0.0050296783,0.09320277,-0.07854406,0.11299382,0.04169175,0.04058937,0.003016354,0.05643968,-0.0633364,-0.017288648,-0.0344948,-0.02757162,0.050103094,0.0029753519,0.024959434,0.0274529,-0.046078235,0.02471492,0.017878292,0.018949527,-0.056909345,-0.060614374,0.029776424,-0.014086199,-0.06002784,0.06700656,-0.015142176,0.091207035,-0.032620765,0.037817996,-0.010471231,-0.041120652,0.026462398,-0.027551943,0.06503521,0.07197371,-0.028713606,0.033550266,0.0040566158,-0.013675388,0.034952633,0.069785215,0.0072760847,-0.0037013108,-0.048128683,-0.0033683327,-0.008307277,-0.036238786,-0.0095559815,0.147352,0.056454528,-0.00601112,0.010749228,0.04692227,-0.047245346,0.08600398,0.10307952,-3.110762e-08,0.07932586,-0.121022664,-0.006552606,-0.037742414,-0.0043735607,-0.007944604,0.017517196,-0.0017782025,0.07927101,0.009524318,-0.038703766,0.030254852,-0.10568933,-0.0020979603,-0.016517252,0.03973215,0.046237785,0.061472896,0.031513274,0.006251174,-0.010187092,-0.013807701,-0.03718222,-0.006863414,-0.017482439,-0.057795048,-0.012920465,-0.019278158,0.0924824,-0.008708108,-0.020180779,0.0062650987,-0.047263313,-0.060410526,0.023881692,0.12759118,-0.017309055,-0.100363754,-0.0006471776,-0.008454563,-0.054868087,-0.08789817,-0.018139422,-0.053033773,0.052748892,-0.07036916,0.046317905,0.03542532,-0.0044799666,-0.04815724,0.0071617467,-0.05165381,0.051279623,-0.14110336,-0.09263703,-0.0039428854,0.029502945,-0.003148971,-0.062221695,-0.09768808,-0.030968983,0.02381239,0.18658142,0.017790858 +1.14.14.124,"A cytochrome P-450 (heme-thiolate) protein. The dehydration of 3alpha-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous [1,2]. The enzyme from fungi also catalyses the reaction of EC 1.14.14.125, monacolin L hydroxylase [3].",384,0.99999994,-0.05797964,-0.03042991,-0.014038821,-0.027829103,0.11051599,0.04877043,-0.018282197,0.08424991,0.00851723,-0.005191866,0.022941686,-0.07602474,-0.07273004,0.028578375,-0.053362314,0.0010296875,-0.062619075,0.004956412,-0.016629811,-0.020052979,0.028441027,0.026491819,-0.047436494,0.037343808,0.04767376,0.011084569,0.10186322,0.050997447,-0.06957274,-0.06275004,-0.04122854,-0.018847922,0.0036205365,-0.049849328,0.059615694,0.10964156,-0.09876695,-0.07522332,0.048204724,0.0050522895,0.0687993,-0.072771154,-0.054388408,-0.0019085725,-0.059712473,-0.013447694,-0.032604635,0.060297836,0.041545514,-0.030916559,-0.03175549,-0.01757711,-0.009262587,0.004013797,-0.059232604,-0.022490624,0.017559582,0.01851163,-0.037539586,-0.03389209,-0.013072098,0.045439173,-0.034196522,0.020257598,0.026108027,-0.033107203,0.046490822,-0.058176525,0.0197971,-0.034816835,-0.052730147,-0.06949421,0.030062247,-0.007839451,-0.025044495,0.06606052,-0.032466948,-0.029257786,-0.019537052,-0.026648529,0.055020392,0.0113537125,-0.008476543,0.0882511,0.011113056,-0.083175264,-0.03673925,0.053706452,-0.001154457,-0.020842426,-0.034927472,0.05059045,-0.051171124,0.0017189049,-0.12123001,0.09330043,0.05859888,-0.01556214,0.0393135,-0.010760247,0.025499633,0.095569275,-0.0024314378,-0.088286035,-0.026263379,0.015331922,0.010173495,0.12404065,0.07768436,-0.06322226,-0.010295495,-0.09171647,0.05266676,-0.025130251,0.007544787,0.079240546,0.01509042,-0.053650063,-0.04948172,-0.0679515,0.018685354,-0.035017855,0.023852509,-0.03760086,-0.07797466,0.050618693,-0.09973067,1.6202977e-33,0.09986131,-0.0015158291,-0.043773774,0.026247052,-0.0064210584,-0.0048469463,-0.103246264,0.06870938,-0.028062966,-0.0037447016,-0.042458147,-0.079034865,0.018001255,-0.042675562,-0.06728656,0.012141402,-0.023063418,0.0021241133,0.023980284,0.07997794,-0.0028527614,0.023403436,-0.04210567,-0.036361095,0.062457904,0.12560761,-0.0074019628,-0.03639213,0.008040452,0.02415881,-0.03584594,-0.09160792,-0.089792304,-0.013839435,0.056724347,-0.047350723,-0.010435557,-0.005334393,-0.002321194,0.0016983323,0.0038517674,-0.010248791,0.060155243,-0.10673424,0.043301992,0.013350197,-0.092591494,0.06982623,-0.022780122,0.010640709,0.11349265,-0.06489698,0.114234075,0.028268222,-0.036691386,-0.007011738,-0.013413586,0.06293882,0.03299507,0.091614515,0.08314255,0.13904643,-0.07056391,0.07270337,-0.005525054,-0.0025347522,-0.049687542,-0.046593376,0.0071814666,0.04931421,-0.080263846,0.029305289,0.07943298,-0.06505683,0.010247374,-0.056130007,-0.021554999,0.018984199,0.02198022,0.068511866,0.04624587,-0.027375424,0.022776553,-0.009763843,-0.053204108,0.045378327,0.05059114,0.00018439667,-0.0747994,0.048009235,0.016826909,-0.10640489,0.05227311,0.015170206,0.024891986,-2.885809e-33,0.12590198,-0.089985356,0.033733882,-0.0849805,-0.041179087,0.10623485,0.02477916,0.013612983,-0.013356184,-0.007239805,0.111715645,-0.013739866,-0.03472216,0.0065218816,0.04411633,0.0016474793,-0.0017484296,0.010585827,-0.008785806,0.027072117,0.036120955,0.037034936,0.0053164824,0.033039656,0.11076883,0.0139065245,0.04521952,0.047604382,-0.0066489694,0.062465496,-0.0565027,0.07602179,-0.042054556,-0.05517391,-0.042128723,0.043154158,-0.022006873,-0.034747723,0.031058835,0.04836359,-0.024829693,0.0089068515,0.024813103,0.05528654,0.03506345,0.09998205,-0.0830328,-0.07605708,0.025831407,0.02215342,0.03861007,-0.0137621835,-0.052535105,0.02174438,-0.04761227,0.01397598,0.008567117,0.026015569,-0.0035290078,-0.021243708,-0.066044204,-0.030742168,-0.02492146,0.07468875,0.015718972,0.083767675,-0.050285883,0.028680224,0.073552676,-0.031027904,0.069164395,0.007082096,0.023706192,0.107703716,0.024402345,0.005165936,-0.010426246,-0.018552447,0.046684444,-0.015029938,0.02985657,-0.008569402,-0.01476595,-0.061818898,-0.01786879,-0.1374625,-0.040625546,0.09078078,-0.045791324,-0.044642437,0.018983627,0.0020197418,-0.031154424,0.037773333,0.05937332,-4.164791e-08,0.012428378,-0.06708897,0.025261773,-0.022585297,0.0397962,0.016535962,0.06271093,0.017330425,0.08747017,-0.03647036,-0.0012962185,0.044002272,-0.021554964,0.033361543,0.0071495506,-0.006001544,-0.023407185,-0.0012097802,-0.0059023425,0.0017804567,-0.02703798,-0.024101477,-0.103890985,0.020182405,0.0056926683,-0.10317703,0.0045746826,-0.017217942,0.040774245,-0.015945535,-0.02847651,0.035194017,-0.023580475,-0.007687606,0.010776934,0.018913724,-0.07332132,-0.048449527,-0.04767932,-0.04468782,-0.005856297,-0.021993743,-0.11374364,-0.054004,-0.02945978,-0.03701776,0.016065102,0.05680317,0.030815117,-0.019081559,0.025450137,-0.008837446,0.007483873,-0.065864645,-0.085181296,-0.0074709025,0.06435847,-0.053483173,-0.064743355,-0.08658274,0.059746787,0.019614944,0.14920278,-0.030997379 +1.14.14.125,"A cytochrome P-450 (heme-thiolate) protein. The enzyme from fungi also catalyses the reaction of EC 1.14.14.124, dihydromonacolin L hydroxylase.",384,1.0,-0.053163942,0.036456726,-0.019097798,-0.042037457,0.08720768,0.042082015,-0.022993349,0.0789461,0.0007593545,0.011097254,0.027232613,-0.087028734,-0.07270954,0.031663045,-0.05374263,0.022390803,-0.052469946,-0.010671885,-0.009272903,-0.048044905,0.016205996,0.047524154,-0.0068673664,0.057738353,0.010149554,0.027520718,0.07146022,0.07280665,-0.07083065,-0.065711215,-0.035053026,-0.04156881,0.057430476,-0.032803997,-0.00489286,0.10359526,-0.07920852,-0.08393689,0.04443075,-0.01481878,0.043757852,-0.048287176,-0.047172476,0.0008590095,-0.06740454,-0.030259077,-0.0030438274,0.052397944,0.05635193,-0.04912368,-0.02636347,-0.0108658215,-0.0122452015,0.022157129,0.0015898347,0.007428224,0.010722456,-0.0028119355,-0.018933665,-0.040196992,-0.03160109,0.016890429,-0.022365581,0.008311966,-0.019637257,-0.05392627,0.0114813,-0.04830621,-0.028606126,-0.040678836,-0.06023961,-0.0764271,0.008037313,0.016502999,-0.021710606,0.08457704,-0.03336508,-0.03460109,0.011580696,-0.012008844,0.049064454,0.016858801,-0.02736178,0.07661989,0.028737683,-0.06663318,-0.0034552487,0.043166332,-0.0039610723,-0.03304424,0.028329449,0.04152914,-0.012530801,0.016231133,-0.09854076,0.08447692,0.049603768,0.040730562,0.044715438,-0.02862713,0.048339363,0.10160251,-0.02424761,-0.110146396,-0.072370484,0.008020611,0.021152506,0.14686178,0.0750937,-0.075157955,-0.00810955,-0.09747401,0.038075518,-0.031316053,0.0041888696,0.058174536,0.024818182,-0.030007362,-0.04612502,-0.04350179,0.010359968,-0.032526325,0.013008618,0.0071746404,-0.06953768,0.03276957,-0.12503569,1.1906886e-33,0.10050395,0.041268177,-0.06957887,0.0054868213,0.007414906,-0.0012765224,-0.075762,0.07132312,-0.030024402,-0.038486745,-0.06766716,-0.04460638,-0.013810507,-0.023990229,-0.055872094,-0.004514621,-0.025078185,0.011793137,0.023863168,0.07261022,-0.012932544,-0.0062510283,-0.0646762,-0.012570172,0.055990733,0.11396669,-0.021724476,-0.016438097,0.019089272,0.011125379,-0.04345076,-0.07931811,-0.08508847,-0.018858993,0.037837993,-0.045983054,0.009065395,0.0009536147,-0.01711068,-0.0052983784,-0.026618175,0.0009692464,0.041947987,-0.111164235,0.06297569,0.0066479696,-0.08284895,0.06714335,0.0001850214,0.036539163,0.10047763,-0.049987245,0.1325733,0.010051349,-0.039055977,0.013448527,-0.020132452,0.05330887,0.019945841,0.08122742,0.08091434,0.1264957,-0.047297,0.08029831,0.0019655917,0.015250872,-0.02403476,-0.02703823,-0.005942412,0.08970828,-0.07957462,0.02525955,0.07105803,-0.07598662,0.026847553,-0.048217468,-0.05278897,0.025064113,0.0012887064,0.08461837,0.025566166,-0.0143289585,0.008852023,-0.029565249,-0.0089628985,0.026727723,0.025482455,0.024301924,-0.054136384,0.03568455,0.013162479,-0.107549354,0.02102677,0.027810004,-0.008012581,-2.1609884e-33,0.13231018,-0.09862371,0.044526264,-0.08521387,-0.06514584,0.105126396,0.015386738,-0.02440954,-0.02607545,-0.020020265,0.10742685,-0.058307547,0.011503577,-0.017879337,0.024381723,-0.014608129,-0.043104146,0.045726284,-0.018154396,0.034416728,0.005457826,0.0233077,0.0013689509,0.030260513,0.090206504,0.011974462,0.043652438,0.043131202,0.038388215,0.020377977,-0.060133934,0.035212807,-0.03018587,-0.056231312,-0.05316637,0.062213242,0.0035104388,-0.030247286,0.030030744,0.031467743,0.006555189,0.033072915,0.028381689,0.0678591,0.0166653,0.104002126,-0.07487171,-0.023330973,0.0005750088,-0.017631736,0.04130708,0.026864927,-0.025845096,-0.0015149253,-0.041907676,0.009271472,-0.008179779,0.027347093,0.009785934,-0.029211601,-0.07295052,-0.052474212,-0.010089994,0.0849308,0.012175459,0.096704595,-0.086982556,0.027883949,0.05509535,-0.0012018676,0.09434306,0.0001918603,0.034386765,0.09377018,0.032056596,0.029213125,0.002203147,-0.013537784,0.04229872,0.036536742,0.04258198,-0.012704638,-0.006901928,-0.07663012,-0.015295045,-0.106976956,-0.016295146,0.09377002,-0.08406325,-0.017880304,0.010530915,0.027714401,-0.015747262,0.043179702,0.062512785,-3.162576e-08,0.009397329,-0.06866434,0.03748816,-0.074280955,0.041575074,0.0232098,0.07238936,0.010392806,0.07076655,-0.038811836,0.0009933223,0.047568094,-0.017800841,0.036894005,0.025065651,-0.010889432,-0.007412752,-0.00034726594,0.016557474,0.029049577,-0.01648616,-0.024185155,-0.084996276,0.050030857,0.024596069,-0.109514356,-0.0036972268,-0.010882188,0.0143246865,-0.008587227,-0.028927293,0.019493036,-0.04488811,-0.013352042,0.0278821,0.02000378,-0.0918408,-0.079438634,-0.039055686,-0.03579677,0.007030133,-0.05124703,-0.09964729,-0.055095315,-0.0107173445,-0.022275256,0.019799823,0.05748355,0.00040025063,-0.025741158,0.044691935,-0.018480979,0.030393837,-0.1169803,-0.10568078,-0.010497107,0.10024052,-0.058433834,-0.05318475,-0.0830688,0.057773996,0.004526514,0.1876709,-0.029191755 +1.14.14.126,"A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can also convert alpha-amyrin and lupeol to ursolic acid and betulinic acid, respectively. The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not catalyse the reaction to completion, resulting in accumulation of both intermediates.",384,0.99999994,-0.07392175,0.015457018,-0.10397383,-0.011894573,0.03506366,0.018338269,-0.061595976,0.07862712,0.049554437,0.0030229397,0.017543549,0.0676144,-0.067321315,-0.03666591,-0.06695087,0.0041111344,-0.08356296,0.035392735,0.008771485,0.0059850314,0.073237725,0.030198216,-0.0065450566,0.019916192,0.029517706,-0.048599996,0.014830025,0.034001168,-0.061724413,0.000704587,-0.008077101,0.008596858,-0.0084771,-0.054065116,-0.019137837,0.054127645,-0.12514323,-0.09735784,0.04619913,-0.044724993,0.100816935,-0.0067800055,-0.056105632,0.0031834103,0.009265772,-0.07150817,-0.06332204,0.035939083,0.050198156,-0.054420177,-0.05655478,-0.047119588,-0.015837003,0.017125435,-0.044802696,-0.029216556,0.026320055,-0.05120072,0.0073488397,0.06947181,-0.024406195,0.07088432,-0.04104737,-0.017448083,-0.020061377,-0.059702367,-0.091796674,-0.009778741,-0.016573146,-0.06835345,-0.078506164,-0.0922885,-0.01433556,0.028406654,-0.049716882,0.049613446,-0.02932923,0.060588762,-0.010156724,-0.024408013,0.03553968,-0.052097578,-0.0036258658,0.13649258,0.026659332,-0.025681721,0.02207546,0.037374943,0.020017222,0.008572014,0.08247805,0.06333648,-0.026782895,0.016517296,-0.0125528965,0.038175188,0.03749196,-0.036844995,-0.020092838,-0.016229676,0.016834926,0.047816217,-0.00044783254,-0.19642942,-0.05146962,0.0664028,-0.030466622,0.010592932,0.067937225,-0.04861435,-0.021740273,-0.045960948,-0.00089733815,-0.011046334,-0.035823356,0.067959696,-0.045990195,-0.095328204,-0.020799484,-0.06110371,-0.016871648,-0.04444868,0.07960052,0.010051803,-0.00957809,-0.0017070988,-0.071957305,3.914971e-33,0.10035202,0.0011641104,-0.009320517,-0.016251644,-0.0113413995,0.034855954,-0.024611654,-0.018017672,-0.016272994,-0.06908623,-0.17036818,-0.059814245,-0.028700303,-0.0581732,-0.030668672,0.021754535,-0.021387538,0.038696762,0.06785637,0.047834493,-0.006472302,0.0090522645,-0.0754416,-0.042058818,0.012908385,0.11279612,-0.056581087,-0.031275667,0.034544375,0.002034547,-0.01593319,-0.047881808,-0.051588446,-0.020442484,0.09056043,0.017376008,-0.0060475026,-0.04729789,-0.09352207,0.02064208,-0.005583974,0.0012365284,0.07966036,-0.00030294064,0.06670859,0.017597698,-0.09679865,0.047895186,0.027360277,0.096453674,0.005811091,-0.023077972,0.081598945,0.045885626,-0.087218635,-0.02057579,-0.010176183,0.031246554,0.03766004,0.03224475,0.03695432,0.05989473,-0.03306871,0.010009586,-0.023160828,0.10760657,-0.09612689,-0.028325481,-0.03105265,0.11997397,-0.03999052,-0.045898773,0.057265718,-0.020445326,0.030811878,-0.0274202,0.015919536,0.049067207,0.00414183,0.068361856,0.02138059,-0.0442539,-0.04310015,0.018532498,-0.012540932,-0.011294842,0.009353888,0.015998438,-0.006214659,0.01648192,0.07143771,-0.021169884,-0.022537095,0.07042536,-0.015059445,-5.406879e-33,0.11318795,-0.10721722,0.062158864,-0.056538623,-0.006489697,0.04968821,-0.03790617,-0.09954363,0.025751147,0.019630961,0.0907947,-0.07225951,0.036093563,-0.019160397,-0.023019861,0.014522688,0.033873584,0.061461072,-0.058919035,0.04431161,-0.02665483,0.07536017,0.047898367,0.0509118,0.0044277376,-0.033657774,0.054040127,-0.016424393,-0.024105093,-0.00061371026,0.02926398,0.015807262,-0.09289259,-0.028522529,-0.04812449,0.07698059,0.027018923,-0.03226734,0.055593148,0.054682456,0.0059856,0.008693423,0.033222217,0.0769952,0.08747752,-0.007345412,-0.10065805,-0.012412351,-0.053678084,0.0020268627,0.14529784,0.019840097,0.039826006,0.04346369,0.04128218,-0.016396847,0.01657605,0.0072562792,-0.058399066,-0.02076522,0.01263896,-0.058146402,-0.038886204,0.025807116,0.0012276628,0.009832109,-0.046787664,0.060489736,0.0028251912,0.01346623,0.0589747,0.033977993,0.07093228,0.1057699,0.035022866,0.04069745,0.0017912007,-0.07781118,0.005177437,-0.02790748,-0.0173577,0.0359873,6.391694e-05,-0.07137719,-0.09965148,-0.077383876,-0.034693956,0.07211279,0.0133970035,0.003441378,-0.02973999,0.041318048,-0.014853805,0.055808872,0.04973304,-4.371154e-08,-0.0021676195,-0.018656692,-0.0063055553,-0.0073820227,-0.012331879,-0.033296555,0.008519127,-0.002173758,0.044458874,-0.050568108,0.015383255,0.10973766,-0.025595887,-0.012660332,0.07234477,-0.012508816,0.042695314,0.044350736,0.025177704,0.066535026,-0.009281594,-0.015804691,-0.06798327,0.0014747946,0.04481131,-0.12868622,-0.012780598,0.013712716,0.013119982,-0.00422447,0.047743052,0.0006476617,-0.032822706,-0.0129465535,-0.006113708,0.067599155,-0.0024560578,-0.05794937,-0.0339461,0.024190418,-0.01826247,-0.06564375,-0.059639066,-0.05908221,-0.03369735,-0.008442617,0.09434553,0.027389428,0.033679996,-0.026460793,-0.012710007,0.001875709,0.030910386,-0.106898814,-0.013071422,-0.051348444,0.0669915,5.7359193e-05,0.009034309,-0.08397597,0.0057489495,0.00756785,0.1856205,0.04388678 +1.14.14.127,"A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2]. ",384,1.0,-0.02429714,0.025589485,-0.03203321,-0.030190296,0.084581316,0.11236192,-0.009519605,0.05318477,0.0027796335,-0.019165361,0.026152711,-0.0569553,-0.07748608,0.052510418,-0.017113648,0.06664626,-0.02537209,0.017531907,0.0036348198,-0.057391733,0.034879465,0.05057069,0.046309218,0.0062954896,-0.030340616,0.032153476,0.013490584,0.005902134,0.01365435,-0.07847541,-0.054570906,0.0027966613,0.033421583,0.012190152,0.039578184,0.10437251,-0.061366275,-0.07142078,0.024674123,-0.026152465,0.09296853,0.030482845,-0.06185928,0.043919306,-0.04880169,-0.01645867,0.01946704,0.024063,0.025558738,-0.0150699215,-0.00013311664,-0.09808418,-0.05727979,0.0413697,-0.019287303,-0.022784255,0.029707868,-0.03652345,-0.02925458,-0.028905971,0.035543397,0.05729744,0.020750869,-0.012134541,0.004676602,-0.048458293,-0.025335237,-0.04940076,0.02396589,-0.124456644,-0.055038355,-0.081334226,-0.0693194,0.08822568,-0.062255546,0.044896755,-0.024528082,0.006879263,0.009986132,-0.005746245,-0.025587946,-0.028591396,0.016150184,0.0893906,0.1071189,-0.025916163,-0.03636894,0.087398455,-0.03310515,-0.014605172,0.020826988,-0.039071698,-0.033178084,-0.024936719,-0.051739134,0.014899911,0.020927459,-0.024134368,0.004012419,-0.014702938,0.062147025,0.023102678,-0.00556705,-0.064641654,-0.06690332,-0.010830387,0.010463954,0.039717253,0.07443858,-0.07443154,-0.080642894,0.005309084,0.08677613,0.008013176,-0.009848335,-0.031540647,-0.04692657,-0.047967106,0.032157473,0.0031184354,-0.040185694,0.026897075,0.04307971,0.035150982,0.015309845,-0.014074564,-0.18056533,7.129549e-34,0.090414494,0.046105247,0.018069895,-0.022206143,-0.0648433,-0.004931209,-0.028619787,0.08654553,-0.01279028,0.0025565042,-0.07593391,-0.06594108,0.053200003,-0.013592244,-0.0091725085,0.03833172,-0.038277563,0.017575927,0.11102096,-0.04897754,-0.08059066,-0.0036836474,-0.020054951,-0.05999934,0.08114782,0.11264346,-0.03479271,-0.02642638,0.039421443,0.015073997,0.029419784,-0.08676097,-0.029135654,0.017129913,0.03608365,0.0034025465,-0.025791273,-0.048393913,-0.095428005,0.026037488,-0.0043662684,-0.06410166,0.0011236084,-0.07048927,0.053368915,-0.0853023,-0.16802314,0.053343665,0.036637634,0.0063493294,0.07337823,-0.031177687,0.0685103,0.02511966,-0.109104685,0.011810656,0.012821516,0.03085975,-0.027464673,0.00084716256,0.06792157,0.063154526,-0.03780699,-0.0022257494,0.064140275,0.031202052,-0.04079843,-0.015872285,-0.053515494,0.10708851,0.005518271,-0.04090577,0.04718863,-0.037797086,0.013512256,-0.02224763,-0.0475034,0.032824453,0.05734275,0.03995021,0.033925567,-0.03488588,0.0025592418,-0.032252636,-0.052666523,-0.034647737,0.07924402,-0.017741878,-0.0018965987,0.095707834,0.030928362,-0.11510909,-0.009027743,0.027148716,-0.025082182,-8.657766e-34,0.018062767,-0.049902096,0.03342639,-0.08071252,0.029936252,0.045006704,0.027723858,-0.01183694,-0.030122288,0.0006042152,0.11432166,-0.016716266,-0.017027505,-0.05521154,0.034974173,0.041412983,-0.03101913,0.016586103,0.07550384,0.03763097,-0.03246856,-0.017786302,0.012564869,0.059241988,0.01968766,0.036608413,0.060564984,0.020964043,0.045443848,-0.020289317,-0.04270384,0.05105711,-0.010486203,-0.0700017,-0.04907795,0.016279973,-0.029247068,-0.03232362,0.03414392,0.031110514,-0.031866796,0.06766208,0.014258799,0.05143125,0.044549774,0.12643175,-0.067075886,-0.07850791,0.024493033,-0.009961171,0.052235838,0.031594276,0.0017694775,0.029920261,-0.03555978,0.02517157,-0.07158949,0.030148497,0.0059819845,-0.0789722,-0.04849235,-0.031715225,0.008148719,0.10960981,0.0044613364,0.06979388,-0.085594304,0.07767163,-0.030186672,-0.005703093,0.05604913,0.00060733897,0.06433577,0.10751852,-0.052796636,-0.0037193918,0.059207834,0.019291218,0.07404898,0.008157546,0.0070424764,0.03504823,-0.06393771,-0.037185874,0.0024007023,-0.074723296,-0.05664654,0.10932383,0.01606094,-0.036809158,-0.031416588,0.0390479,-0.035801616,0.037984703,0.101447545,-3.550894e-08,0.019087577,-0.13736589,0.0087978365,-0.05488476,0.033606052,0.024046121,0.04654737,-0.01017379,0.0026671677,-0.0040190667,0.04936715,0.017796436,0.0021350035,-0.002298535,0.047195252,-0.020232549,-0.0034645565,0.012411443,0.030350933,-0.0070130485,-0.042653088,0.083318636,-0.04545342,-0.00617655,0.0398197,-0.06312802,-0.020156048,-0.012055665,-0.017846758,0.017877104,0.002747262,0.07607699,-0.003822656,-0.004150015,-0.0425643,0.049463682,-0.009874801,-0.04841676,-0.045896158,0.008375502,0.006730445,0.0015053785,-0.05931962,-0.059259847,0.052022558,-0.03281265,0.09651787,0.062429603,-0.016724963,-0.054635167,-0.00991226,0.016076475,-0.03854661,-0.108093284,-0.12046484,0.00036298833,0.032784183,-0.08250331,-0.06388539,-0.09158273,0.055911668,-0.023266358,0.18059534,-0.011167575 +1.14.14.128,"A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.14.127, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone.",384,1.0,-0.0395222,0.038385022,-0.04114094,-0.018228702,0.07745345,0.103389814,-0.029652203,0.046269987,-0.01158797,-0.022202423,0.01921843,-0.04696094,-0.088793226,0.04803987,-0.029796511,0.0633334,-0.03629264,0.019195203,0.014714996,-0.06570944,0.02139367,0.021820571,0.05518463,0.024109462,-0.018941216,0.021443313,0.007891482,0.014704879,-0.013226922,-0.07044397,-0.037162077,0.0074189375,0.039123956,0.0015561602,0.026590621,0.09196937,-0.053164873,-0.0768906,0.031173315,-0.014188704,0.09581059,0.015568341,-0.074759945,0.057366103,-0.051695492,-0.011758108,-0.005955931,0.03200073,0.01729559,-0.0009665137,-0.004058963,-0.11963283,-0.041025795,0.051712446,-0.011250561,-0.012128378,0.02953044,-0.023606766,-0.025437433,-0.03187549,0.015802283,0.061773367,0.0051044086,-0.0011607336,0.015831824,-0.053445354,-0.021705564,-0.037722602,0.035929155,-0.12320028,-0.019712113,-0.08870686,-0.036145296,0.07629019,-0.05207571,0.021438915,-0.03885731,-0.0032368777,0.0142402435,-0.013028873,-0.014630296,-0.034305755,0.018494327,0.097434975,0.08922153,-0.050208233,-0.028170055,0.067643344,-0.04650256,-0.009325574,0.024303034,-0.04278758,-0.03760589,-0.0153070185,-0.050326757,0.025184184,9.193898e-05,-0.036276564,-0.0109772645,-0.030501802,0.06774477,0.020548815,0.0050884504,-0.05972424,-0.08462211,-0.014005518,0.006897843,0.036481775,0.05118283,-0.0637451,-0.07986216,-0.010361978,0.08994766,0.018053353,-0.016656945,-0.01659227,-0.053768054,-0.037399467,0.018847685,0.0022816295,-0.038531397,0.040533915,0.04165762,0.052625995,-0.0013299652,-0.0069650975,-0.17992824,-3.4835959e-34,0.094983764,0.04721642,-0.005984577,-0.01460805,-0.06622545,0.010504834,-0.014649328,0.074679084,-0.043115474,-0.0013179366,-0.07167336,-0.06739606,0.041801766,-0.032645345,0.0058258534,0.020307988,-0.02808402,0.03379209,0.11366502,-0.016007703,-0.056905165,0.0012410915,-0.021397125,-0.06861661,0.07746648,0.12627663,-0.03964094,-0.0137339635,0.019668264,0.016967,0.04779167,-0.094850786,-0.024050768,0.018070014,0.023673622,-0.021129267,-0.016645113,-0.05611859,-0.08973939,0.03659247,-0.015878983,-0.08091609,0.013316777,-0.069772184,0.051617544,-0.07888679,-0.16290903,0.057225443,0.04499037,0.033431906,0.0848077,-0.05080264,0.065716036,0.018631712,-0.09875922,0.04212802,-0.006255712,0.00893471,0.005370572,-0.015246715,0.080088146,0.0708505,-0.029835137,-0.020858534,0.06404787,0.022547206,-0.03649614,-0.0038099417,-0.06617008,0.136961,-0.0013090379,-0.0613173,0.024576534,-0.039917137,0.03592377,-0.010064745,-0.026373602,0.058457255,0.04073508,0.027271936,0.060761727,-0.0461006,-0.013782183,-0.02008454,-0.041080147,-0.04136,0.06557671,-0.0017146531,-0.00021080264,0.12801641,0.03548241,-0.13496074,-0.00801728,0.028674819,-0.019959752,1.5449674e-34,0.0419797,-0.066133834,0.031464517,-0.086106166,0.025716268,0.055707056,0.035733618,-0.00038768983,-0.0040337355,0.030921813,0.111217774,-0.016525934,-0.017427256,-0.06836795,0.03346915,0.04035924,-0.026360946,0.027197052,0.074369594,0.022730302,-0.04091325,0.0042826775,-0.005690557,0.062888354,0.019664338,0.030523317,0.0655615,0.013238954,0.041467264,-0.00642534,-0.046198715,0.030568564,-0.0076358314,-0.05267814,-0.049969647,0.018938448,-0.037583534,-0.010490189,0.0314909,0.014441983,-0.029012077,0.069969386,0.01577909,0.050746705,0.03662762,0.11117008,-0.06858174,-0.054518662,0.027406538,-0.00057762204,0.042376608,0.029587572,0.011859454,0.029703865,-0.06390144,0.014944313,-0.065074384,0.021803478,0.0068805926,-0.080412686,-0.03498383,-0.040612623,0.0017967157,0.09793687,0.013232918,0.0655702,-0.0984455,0.059822604,-0.027061183,0.015306368,0.07197926,0.013820956,0.06902705,0.11586897,-0.04979391,-0.018388014,0.041681666,0.013084952,0.07914126,0.010406525,0.022971213,0.021537155,-0.05171319,-0.041420262,0.008008088,-0.0910253,-0.041364968,0.11510051,0.024696862,-0.047303624,-0.03244002,0.048669774,-0.044784706,0.023076953,0.11354408,-3.55704e-08,0.017180353,-0.12262006,0.009334607,-0.028688444,0.033571843,-0.00062662474,0.04052331,-0.019327464,-0.0011988442,-0.012436922,0.02177904,0.038779482,0.017623669,-0.018750599,0.054923266,-0.028090632,0.0076153874,0.02244146,0.0360084,0.0010626462,-0.0135681,0.07447797,-0.05244173,-0.010814719,0.030688768,-0.069758594,0.0038741264,-0.0049058828,-0.026794584,-0.0043760235,0.02464914,0.06504816,0.0040575364,0.0021282397,-0.036123272,0.045115236,-0.023798143,-0.05337019,-0.044728316,-0.018522162,-0.001511036,-0.005758511,-0.046363503,-0.054463163,0.033851694,-0.036845807,0.113335356,0.036244992,-0.0075192656,-0.01723552,-0.0059063714,0.006839793,-0.022073226,-0.10643753,-0.102436826,0.0009004953,0.04234351,-0.0931928,-0.059666444,-0.087200716,0.058963787,-0.012745139,0.20109306,-0.013868885 +1.14.14.129,"A cytochrome P-450 (heme-thiolate) protein. The enzymes from solanaceous plants are involved in the biosynthesis of stigmatic estolide, a lipid-based polyester that forms a major component of the exudate.",384,1.0,-0.05986488,-0.018829362,-0.032514952,-0.017429193,0.071802564,0.084291115,0.018725712,0.09936565,0.02348169,-0.009934334,0.045323767,-0.050733916,-0.1059545,-0.013456175,0.026869755,0.072844066,-0.095548,0.015401342,0.003941317,-0.06261357,0.034370087,0.08357592,-0.015236421,0.009494242,0.0054386067,-0.033422213,0.0074575627,0.007613516,-0.015370622,-0.05700195,-0.046828948,0.0114434445,0.052126765,-0.044273686,0.021810964,0.118867606,-0.036444686,-0.088627316,0.024527539,-0.06219692,0.08527853,-0.03052628,-0.10023939,0.03089252,-0.034645706,-0.025486177,0.03265633,0.07325125,0.012769621,-0.092209056,0.0006615966,-0.06300058,-0.08238576,-0.018872716,-0.08175948,0.004400961,0.07445623,0.0036812793,-0.022346405,0.005888394,-0.00042397773,0.031586908,0.014675874,-0.001718696,0.021144511,-0.044490345,-0.008792645,-0.012647876,0.021804199,-0.10005853,-0.012832889,-0.10003777,-0.084891975,0.037193395,-0.08595775,0.09743762,-0.06795818,0.014005578,-0.017083213,-0.007651625,0.03445848,0.00882429,0.0072533386,0.09200455,0.06972872,-0.022146225,-0.028902587,0.077355176,-0.04769661,-0.010828331,0.010692087,-0.016820943,-0.047215752,0.0430735,-0.076511495,0.06269495,0.04881636,-0.052867312,0.023256885,-0.0014424404,0.03041792,0.025728412,-0.052557416,-0.07512357,-0.060470343,-0.02797311,-0.0008510801,0.009459774,0.0002041326,-0.04543273,-0.08445681,-0.06301674,-0.0020002546,-0.025886748,-0.029891985,0.07467644,0.005224916,-0.018061744,0.0048087947,-0.0759355,-0.062939554,0.03909804,0.043177873,0.073555574,-0.015763065,0.015996404,-0.12735139,1.6924668e-33,0.099433616,0.014565973,0.006179294,0.024521997,-0.026895415,0.003349831,-0.045664515,0.00062731694,-0.020957854,-0.010306992,-0.106778204,-0.11846433,0.0195523,-0.0039016942,-0.00063126255,-0.02414308,-0.043986443,0.076469794,0.06321893,0.009149331,-0.07505278,0.004725469,-0.055634104,0.01441021,0.008638734,0.06258851,-0.05343937,-0.049638767,0.030091029,-0.010265203,-0.047443043,-0.08685141,-0.029677551,0.0064192256,0.07313686,-0.012678064,-0.018773086,-0.040913776,-0.042950086,0.033020783,-0.010621539,0.019536171,0.083808914,-0.07830504,0.011403355,0.026783474,-0.12943503,0.050694227,0.014620845,0.022267383,0.038164172,0.0030842768,0.15338588,0.072175086,-0.030548444,-0.008030892,0.0018729729,0.071666315,-0.0128876185,0.02496797,0.09528712,0.05743911,-0.048719257,0.03365379,0.040377956,0.08765865,-0.075320795,0.02087761,0.005009267,0.12976743,-0.0443141,-0.01349071,0.084531516,0.020315,0.062333338,-0.0048628966,-0.011035385,0.08937059,0.0012226801,0.04782009,0.013824788,-0.034915626,-0.070831716,-0.0685576,-0.0355208,0.024647783,0.036429487,-0.006031251,0.013410449,0.041709,0.069244094,-0.036057968,-0.031306896,0.056697797,-0.04149592,-1.874219e-33,0.065723255,-0.039999213,0.035774082,-0.09813008,-0.032239623,0.020386405,-0.020928457,-0.038483705,-0.008743051,0.011296798,0.06899135,-0.00673611,0.05116586,-0.0066678263,-0.04886405,0.008181542,-0.012282646,0.054244302,0.015144028,0.020700075,-0.08173375,0.004597057,0.017926147,-0.005969723,0.052021783,0.03855083,-0.019821675,0.0018115412,0.0076554744,-0.037060145,-0.05302161,0.029160332,-0.07646176,-0.06454608,-0.058069907,0.011126458,-0.0075795045,-0.0052438863,0.04932065,0.049736355,-0.050989743,0.08029828,0.061612163,0.040492658,0.02098865,0.063489325,-0.06240049,-0.026362179,-0.031791903,-0.015794115,0.036110263,0.010582786,0.026971713,0.0582081,0.004874729,-0.042469673,-0.011913816,0.051361796,-0.04798719,-0.033805914,-0.013156121,-0.052098084,-0.0077676605,0.04296478,0.026123932,0.052472133,-0.041040454,0.027359052,-0.011273297,0.02281077,0.090627246,0.028349144,0.027469344,0.13400446,0.009029842,-0.026396623,0.007656748,-0.07080958,-0.0028516026,-0.037182853,0.005905691,-0.0040363716,-0.053977847,-0.06756304,0.022579594,-0.046218086,-0.04567642,0.09349159,0.04502823,-0.00024396027,-0.056337483,0.03138071,-0.020631034,0.0992453,0.09207619,-3.7731642e-08,-0.0036626093,-0.06707363,0.0045790155,-0.06090819,0.0043105525,-0.0012696186,0.040372897,0.014618174,0.05066071,-0.043606065,-0.035076734,0.06261719,-0.018350609,-0.0071439086,0.044939887,-0.003869889,0.047823623,0.049110323,0.014799698,-0.031791728,-0.024348589,0.015588367,-0.07770977,0.019517632,0.035568766,-0.07996321,0.04492115,0.013524934,0.05811016,0.0494947,0.05514895,0.03906341,0.0015437454,-0.033794083,-0.009526186,0.08252253,-0.031188356,-0.08605618,-0.026726218,0.01761469,-0.018833237,-0.038845293,-0.0860018,-0.04099198,0.038882744,0.009014168,0.009655624,0.081833914,0.009601705,0.015080961,-0.005626998,0.0073519545,0.025031112,-0.082933426,-0.085522234,-0.00031457836,0.060388103,0.01166832,0.008636381,-0.062150158,-0.0032383201,0.003448034,0.2760485,-0.034958355 +1.14.14.130,"A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in the synthesis of sporopollenin - a complex polymer found at the outer layer of spores and pollen. It can also act on decanoate (C10), myristate (C14), and palmitate (C16) with lower activity. The enzyme also produces a small amount of products that are hydroxylated at neighboring positions (C-6, C-8 and C-9).",384,0.99999994,-0.07538175,-0.01616943,-0.030305449,-0.051029127,0.09036373,0.075892486,0.026701331,0.06469355,0.0034656697,0.03610551,0.087961234,-0.023070183,-0.0741633,0.0644442,-0.07051465,0.04401096,-0.07338577,0.010420496,0.018909164,-0.029601118,0.022301333,0.035903465,-0.032537814,0.054218654,0.020102184,-0.022979802,-0.01343085,-0.005804703,-0.027281525,-0.013644379,-0.06415047,0.050113697,0.046150155,-0.017185701,0.03647617,0.115529366,-0.041050773,-0.06162236,0.08114722,-0.035445824,0.071110725,-0.026764285,-0.06985566,-0.009885222,-0.037947904,-7.119528e-05,-0.009231956,0.06915916,0.020905782,-0.024963737,-0.046189122,-0.029651655,-0.050472714,-0.029831594,-0.027888548,-0.02811901,0.012944284,0.03729628,-0.022414556,0.0062487223,0.022416713,-0.028996447,-0.039781343,0.009200231,0.0070756124,-0.07976996,0.014835391,0.017272867,0.03088618,-0.030257715,-0.020005483,-0.064384356,0.009998231,0.06835789,-0.049209792,0.08868831,-0.055956278,-0.036244366,-0.053398483,-0.0288465,0.062027995,0.032090448,-0.019129548,0.105780564,0.081643485,-0.015581134,-0.005675869,0.080994405,-0.015860373,-0.0041014315,0.041442644,0.05120811,-0.075810805,-0.019120837,-0.13683678,0.10194898,0.028232904,-0.018034881,0.010910174,0.009533615,0.04173332,0.04527671,0.012349114,-0.13747253,-0.0313308,0.024871055,-0.111411564,-0.010459518,0.038755618,0.00065752916,-0.06913203,-0.0013476383,-0.007896169,-0.015789198,0.0016946706,0.07297141,0.019870108,-0.024816306,-0.03007521,-0.0071084746,-0.043632746,-0.046468135,-0.014072958,0.04066592,-0.037705537,-0.0056291004,-0.102927424,-1.0901474e-33,0.1105445,0.01939469,0.027900072,0.0835282,-0.0048744217,-0.02558308,-0.046494808,0.037912697,-0.09407469,-0.032729283,-0.11451068,-0.112946354,0.027798492,-0.006740143,-0.0321372,-0.036456063,-0.030644806,0.031009642,0.051343825,0.0007790065,-0.054549646,0.021554304,-0.08807406,-0.027917603,0.03769281,0.07847665,-0.036702383,-0.07651681,0.029934738,-0.018159369,0.008927284,-0.033313014,-0.071410015,0.031032821,0.07105611,-0.02827769,-0.029507985,-0.07971695,-0.0340341,0.06761958,-0.010086138,-0.015333842,0.09556087,-0.05379604,0.033875607,-0.029838588,-0.084881485,0.023481615,0.042293172,0.06310306,0.084489465,-0.065874405,0.09681377,0.043979388,-0.08733651,0.024759093,0.004088304,0.013839962,0.042271618,0.031348396,0.07768561,0.046319436,-0.08652655,0.039453484,0.026588626,0.02993649,-0.0970773,-0.056384806,0.0014538515,0.075428836,-0.04931717,-0.05406983,0.04273133,0.008066351,0.07530439,-0.0011517324,-0.054023355,0.056251045,-0.009272277,0.059416052,0.03386604,-0.045335114,-0.0692658,-0.03282111,-0.08739653,-0.0018411394,0.008802708,0.01216123,-0.0041802893,-0.00910718,0.052075468,-0.1108891,-0.031871013,-0.03644945,-0.033813227,-3.6062906e-34,0.051660106,-0.09613751,0.06992265,-0.062219165,-0.08975279,0.06228391,0.0042815055,-0.05687896,-0.03445723,0.011369659,0.079202995,-0.02911916,0.02535716,-0.0010240462,-0.06459932,0.06568994,0.011480616,0.012331633,-0.01264431,0.010382417,-0.050621446,0.044622887,0.04511971,0.056214802,0.026088051,0.0023710344,0.039189324,0.033465743,0.092259586,0.018362835,-0.0723232,-0.015047798,-0.050623316,-0.024513638,-0.01993458,-0.021704394,-0.030607255,-0.010648948,0.016564783,0.02069535,-0.064018875,0.06809861,0.05785543,0.0900479,0.07522795,0.069266476,-0.07515002,0.0034690218,-0.016342144,0.011308323,0.02264786,0.031158289,0.01249484,0.010383196,0.04405461,-0.028139599,-0.031724855,0.0073397337,-0.015322224,-0.034930553,0.0128141055,-0.049662907,-0.065107144,0.081388965,0.04088415,0.114830375,-0.09383223,0.059744526,-0.016186228,-0.03816084,0.030138224,-0.0007440925,0.051599722,0.07182015,-0.03593765,-0.054158185,0.03492532,-0.00562734,0.031473663,0.012395408,-0.006096421,0.008992898,-0.055651598,-0.03559874,0.007939086,-0.071378976,-0.021329725,0.0777148,0.041488044,-0.040338304,-0.0322148,0.0887564,-0.021377662,0.06504607,0.091908604,-4.454373e-08,0.02574864,-0.09250589,0.06708355,-0.08128866,0.03180969,-0.011998738,0.0506267,-0.018415809,0.071058996,-0.0674819,-0.05326172,0.04569668,0.0040209354,-0.03749136,0.04415996,0.037259605,0.021834519,0.020807184,-0.021661919,0.01731769,-0.002400954,0.02156523,-0.11398604,0.042416126,0.061288048,-0.023144636,0.021651236,0.03675713,0.049469747,0.016903711,0.0232787,0.024087103,0.00029093868,0.005762107,-0.01428771,0.066267684,-0.045014605,-0.050080582,-0.025812896,0.009321266,-0.0085539445,-0.055632837,-0.06696969,-0.041376457,-0.0028050987,-0.0046772724,0.033306047,0.03706658,0.038986202,0.052900445,0.032009065,0.078638576,-0.009027395,-0.09519031,-0.12574054,-0.0044733584,0.074403875,-0.05861439,-0.0036853065,-0.08518906,-0.022730792,0.01287326,0.17192931,0.03569993 +1.14.14.131,"A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.",384,1.0,-0.04844355,0.057624348,-0.029739752,-0.0038176107,0.035893675,0.120730475,-0.005927318,0.07516531,0.036172327,0.00798811,0.017684925,-0.035492584,-0.043057777,0.00982616,-0.06296515,0.04339396,-0.058913376,0.011956531,0.0043152533,-0.032645937,-0.02234724,0.0803524,0.026937257,0.05539524,-0.0034642017,-0.024746781,-0.050463043,0.07394627,-0.012449507,-0.019951662,-0.04523572,0.04283026,0.05211773,0.00095185975,0.04047446,0.09424992,-0.060097713,-0.051525727,-0.025895793,-0.009019926,0.089799054,-0.048792947,-0.098091945,0.06372992,-0.033669077,-0.031010685,-0.039417192,-0.03994371,0.01698702,0.018065194,-0.01123727,-0.061725285,-0.056801427,0.013445181,-0.007717749,-0.044307526,0.059488915,0.034884844,0.0118289115,-0.048113562,0.023193715,0.03921383,0.0033942752,0.048577495,0.021269292,-0.047564775,-0.03438107,-0.009654435,-0.007829383,-0.041519377,0.0055516814,-0.08101326,0.026277948,0.04586955,-0.087856434,0.031942755,-0.039870895,0.028703822,-0.042704865,0.0049465992,0.08327962,0.07829785,0.035275474,0.14132269,0.017070012,0.0008057613,-0.013637166,0.037016105,-0.05066227,-0.08559854,0.011399746,0.018859478,-0.03114119,0.004911146,-0.09057284,0.051117856,0.048654415,-0.039631285,-0.012287844,-0.022932291,0.076622315,0.044492636,-0.056843314,-0.13098314,-0.011618246,-0.01020028,-0.06433379,0.0040101656,0.035319973,-0.06166368,-0.046567544,-0.06167352,-0.03984446,-0.015491376,0.0043809153,0.0731081,-0.0045310115,-0.010494762,0.008126064,-0.016123483,-0.0495106,-0.03969156,0.03377315,0.030459188,-0.05494293,-0.026183873,-0.10521183,3.4202228e-33,0.10112215,0.04113102,-0.0010155336,-0.003709245,0.033672296,-0.06190649,-0.038625773,-0.029450454,-0.089459434,0.0122832265,-0.099284716,-0.04483655,-0.014401816,-0.015917502,-0.014735232,0.006292374,-0.11032042,0.042649228,0.0500519,-0.026755793,-0.026216451,-0.029164338,-0.06683732,-0.008631258,0.021408996,0.12780611,0.006221413,-0.04920688,0.02899605,-0.013738388,-0.042331297,-0.049039036,-0.064201705,-0.04413105,-0.017264955,-0.05888436,-0.018580375,-0.023638673,-0.07708747,0.0323702,-0.021619178,-0.04282638,0.028602835,-0.085889935,0.080451466,-0.008615264,-0.12079023,-0.008662687,0.008127085,0.046176374,0.06152126,-0.067777894,0.09283696,0.05687839,-0.08192135,0.008075756,-0.020155305,0.043240767,-0.03032343,0.0499236,0.10394902,0.0027724432,-0.05062425,0.03953065,0.047476813,0.06261609,-0.049239073,-0.053671386,-0.00070458587,0.10081922,-0.06386652,-0.020725718,0.0801344,0.01719735,0.057656143,-0.013344835,-0.018500391,0.09427023,-0.010252677,0.079169646,0.015547319,-0.044451267,-0.02053131,-0.016699862,-0.028621195,-0.04937891,0.075314544,0.025669837,-0.04191497,0.024874259,0.040336788,-0.06515203,-0.008042874,0.023421507,-0.07701873,-4.1056528e-33,0.059292886,-0.03360958,0.055979904,-0.07755773,-0.02745588,0.06718357,-0.02564747,0.000688789,0.0235838,0.0528354,0.10272504,-0.037119757,0.05180556,0.031504966,-0.028468175,-0.012544168,-0.020545831,0.018527085,-0.037786566,0.05994003,-0.061984826,-0.045896355,-0.029785462,0.02838099,0.011054596,0.032232817,0.045797378,-0.025168018,0.014218002,0.015996901,-0.03109269,0.06864946,-0.10081407,0.014724865,-0.03580437,-0.0008418588,-0.03666795,-0.0030059908,0.04418638,0.039568204,-0.0055545205,0.04368463,0.026851183,0.028775988,0.058700275,0.060879633,-0.07146651,0.008643568,0.006932734,-0.008324495,0.03226158,0.06324053,-0.015180586,0.077699505,-0.012459508,0.0013913275,-0.044363853,0.008344639,-0.0141984355,-0.031324245,0.0034886117,-0.03771843,-0.011500562,0.124933906,-0.016257806,0.11466265,-0.06159038,0.024690736,-0.0008372225,0.011670487,0.040694986,0.0108233215,0.0801293,0.0935092,-0.013260007,-0.023206435,0.037517816,-0.038014077,0.048659157,0.03277699,0.029559437,0.02564321,-0.032210216,-0.055570927,-0.017568173,-0.06192984,-0.02393868,0.13170525,0.046174213,-0.067872845,0.020866396,0.06613368,-0.08653164,0.02660346,0.07444956,-3.7170505e-08,0.036982108,-0.06265033,0.021127496,-0.047312405,0.009247662,-0.020386055,0.058029413,0.0017168709,0.054640874,-0.020504544,0.011189234,0.027156373,-0.06977637,-0.026016524,0.013669288,0.02694638,0.026810251,0.050162822,0.054835144,0.033860598,-0.03312078,0.009912657,-0.012197964,0.008569756,0.026145225,-0.06760755,0.022614863,-0.015794618,0.038801506,-0.041680597,0.0283934,0.06857015,-0.08619845,0.007679737,-0.03374964,0.08408728,-0.0015805837,-0.073748335,-0.015654942,0.0015823274,-0.016874552,-0.039478645,-0.07498321,-0.061326135,1.37454845e-05,-0.0078988895,0.09334382,0.032742683,-0.0043471227,0.0008357858,-0.03556489,0.007696488,0.023605367,-0.15205848,-0.11623138,0.035297435,0.05262888,-0.030807225,-0.058730304,-0.09674833,-0.016557826,-0.071328096,0.24313703,0.005872696 +1.14.14.132,"A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency.",384,0.99999994,-0.060150605,0.05841414,-0.022702217,-0.0276535,0.056281343,0.08107521,0.029150564,0.110203296,0.038122296,0.055923667,0.028339501,-0.04759039,-0.042192783,-0.002612131,-0.043474298,0.06487388,-0.03647615,0.01870958,0.030322969,-0.050038964,-0.003655782,0.06807427,0.043560058,0.061764702,0.016894648,0.0010853838,-0.03441663,0.08093837,-0.037129972,-0.02530323,-0.019977825,0.017579393,0.062432356,0.017651567,-0.0013849707,0.08315349,-0.064486854,-0.052288294,-0.031244144,-0.044967562,0.083273955,-0.0264328,-0.0713978,0.044572685,-0.026205858,-0.04968432,-0.056786582,0.0032517533,0.016085738,0.0012687973,0.050826572,-0.080243446,-0.068687476,0.016070567,-0.00056768156,-0.03317049,0.0057868217,0.014852344,0.0061444063,-0.04416579,0.038109004,0.018603843,-0.0073026572,0.07515717,-0.0004410657,-0.025957169,-0.007781995,-0.008216633,-0.01256167,0.008639264,-0.01022061,-0.060194127,0.011320577,0.056896888,-0.0790371,0.03343821,-0.015350512,0.019331194,-0.011668233,0.00096796604,0.07199878,0.12014198,0.028300894,0.10285652,0.06307681,0.047680996,0.0028199486,0.03669059,-0.045135643,-0.11953386,0.030162103,0.01520969,-0.06319512,0.022026028,-0.074781336,0.059190173,0.027884504,-0.062003497,-0.03473902,-0.020115685,0.085662074,0.07712758,-0.04829549,-0.15834992,-0.04378687,-0.0013938629,-0.013923525,0.006294521,0.027324846,-0.036527865,-0.056884162,-0.09751096,-0.043300655,-0.0079671005,-0.013444076,0.104653805,-0.018731583,-0.027832339,0.011392929,-0.049770653,-0.046776325,-0.057436153,-0.009046994,0.035054285,-0.049419235,0.00094022014,-0.074952275,3.0004679e-33,0.104438975,0.012433909,-0.021417141,0.03082286,0.061246462,0.0052761487,-0.011340511,-0.0080394605,-0.08395933,0.009277404,-0.1253937,-0.050880875,0.012594322,0.028051535,0.0031424218,-0.0011650856,-0.07596665,0.065726064,0.07989797,-0.028768364,-0.009812814,-0.043604765,-0.06666632,-0.024916591,0.022472797,0.12952948,-0.05041339,-0.033533078,0.05664902,-0.017500563,-0.059700206,-0.036347933,-0.07545321,-0.027565332,-0.042016953,-0.049395822,-0.04697381,-0.0034741727,-0.031418122,0.06621296,-0.029139481,-0.012708178,0.049199052,-0.0732079,0.085960165,-0.036146104,-0.12069587,-0.003233523,0.0032257973,0.048383575,0.06749119,-0.053362783,0.0885199,0.040276643,-0.08386987,-0.011696199,-0.01757151,0.07393435,-0.019939968,0.042563487,0.11378551,0.047151092,-0.044744477,0.026596438,0.016385537,0.0587329,-0.05167809,-0.06680264,-0.030112308,0.07948708,-0.052314058,-0.028476357,0.03956814,-0.02521992,0.08487662,-0.016135314,-0.026918678,0.09566603,0.014915256,0.08441565,0.028113129,-0.061107017,-0.040564016,-0.0324326,-0.007862921,-0.051954765,0.038971562,0.028590603,0.0037534533,0.033416566,0.059798196,-0.06972464,-0.025344744,0.012893696,-0.050638273,-2.8224933e-33,0.07088743,-0.03417935,0.0278439,-0.06059246,-0.038688306,0.06673291,-0.013993783,-0.03572356,0.030600328,0.03643942,0.110315725,-0.04620885,0.078599505,0.0066744075,0.0033780637,-0.011982622,-0.03733197,0.02885678,-0.009398834,0.054887716,-0.04237863,-0.024702093,-0.005402129,0.037469048,0.041277323,0.033620197,0.040214848,-0.044096746,0.03652796,-0.018464731,-0.06704576,0.030445613,-0.112084806,0.0020622583,-0.06817861,0.024637336,-0.0014339089,-0.023718242,0.031819906,0.038635653,0.0025420154,0.056588788,0.039608713,0.064811654,0.023903469,0.026088968,-0.079612345,0.018998118,-0.005637175,-0.0013474292,0.0011221886,0.044403322,-0.023717921,0.050028235,0.008800008,0.0044317325,-0.039669614,-0.013834069,-0.031333204,-0.02914027,-0.028218161,-0.034568753,-0.037492312,0.10073975,0.0077757193,0.14571822,-0.08948948,0.04561053,-0.016390879,0.025249287,0.052898366,0.008903858,0.0035497558,0.04162559,-0.019350704,-0.032616276,0.06168159,-0.0533954,0.037259456,0.007851356,0.028625818,-0.008174925,-0.04307919,-0.046430804,-0.042776722,-0.053423908,-0.04156507,0.10382257,-0.0018211426,-0.030616095,0.027198173,0.030542094,-0.067640625,0.071757376,0.08486812,-3.682016e-08,0.007504429,-0.08636047,0.026467582,-0.06085709,0.011758608,-0.05488189,0.08036944,0.016617917,0.05691999,-0.045558054,0.00556379,0.05691363,-0.013706377,-0.026708053,0.05072812,0.0384123,0.03336695,0.037069786,0.030642694,0.023378465,-0.014636852,-0.013372265,-0.020961473,0.01670257,0.033188585,-0.06632048,0.04448317,-0.0048346426,0.047017597,-0.0072608455,-0.008649817,0.04491644,-0.083121665,0.012548267,0.008850817,0.050245848,-0.013484227,-0.05492949,-0.043113403,-0.0144474115,-0.028786082,-0.028287467,-0.061374094,-0.05981432,0.020403074,-0.014901793,0.095480986,0.013720592,0.021887157,-0.03061919,-0.052780807,-0.016683374,0.05334123,-0.1451926,-0.121683404,-0.0024510052,0.034144033,-0.015114376,-0.008714118,-0.060581814,-0.023252722,-0.04613463,0.23399429,0.042758483 +1.14.14.133,"A cytochrome P-450 (heme-thiolate) protein that uses a flavodoxin-like redox partner to reduce the heme iron. Isolated from the bacterium Citrobacter braakii, which can use 1,8-cineole as the sole source of carbon.",384,1.0,-0.08613375,0.06097767,-0.085510604,0.045512106,0.08221237,0.081724204,0.021818696,0.08437815,0.005469374,-0.014965959,-0.036311053,-0.0611517,-0.05513736,0.009742891,-0.013423793,0.008530706,-0.023621874,0.04938757,-0.014767945,-0.031406265,-0.032466654,0.056395907,-0.0003163544,0.042812087,-0.03795302,-0.013588448,0.04229733,0.025474649,-0.021170402,-0.038979962,0.027583562,-0.024650969,0.06513484,-0.009404339,0.010274404,0.07719948,-0.054214675,-0.10845347,0.04480365,-0.023853647,0.0350197,0.008420061,0.005287199,0.0067471727,0.009436519,-0.0033087735,0.013402871,0.042616688,0.050859757,-0.05312534,-0.04244251,0.01400094,-0.08382788,0.04196853,0.0033091684,-0.03278484,0.01992575,-0.070252806,0.04016863,-0.029470848,0.034952916,-0.022939935,-0.010607791,0.011982637,-0.01805959,-0.05594653,0.011256178,0.0072061373,-0.00045207894,-0.038300708,0.004166476,-0.033370204,-0.070807874,0.041463878,-0.09499893,0.11409023,0.023140015,-0.01914904,0.030788066,0.05115356,-0.0048248917,0.017572276,0.016632887,0.12255181,0.035471976,0.01814451,-0.060005553,-0.012633794,-0.07402297,0.010889101,-0.015433994,0.08467076,0.044963088,-0.047669884,-0.083240196,0.008433577,0.062091198,0.019182857,0.021742363,0.022280542,0.016328664,0.042959653,-0.008329957,-0.113171905,-0.07709935,-0.0307684,0.025093347,0.06436573,0.12649783,-0.042608775,-0.04313357,-0.029680476,-0.03813659,-0.06729951,0.029652268,0.08640464,0.105953075,-0.027256781,-0.011444856,0.016355317,-0.02981931,-0.012784288,0.027462605,-0.026501246,-0.07375095,-0.01744443,-0.09823764,2.0514972e-33,0.09192399,0.039456617,0.02119271,0.03439873,0.034044944,0.03433521,-0.13306189,0.005644858,-0.026379345,-0.012298983,-0.112844385,-0.0408462,0.034469157,-0.0400065,-0.013448521,-0.06201454,-0.06982313,-0.027647346,0.057354026,-0.030751,-0.02621185,0.0031604506,0.018985678,0.019199822,0.044457067,0.07062044,-0.0074629677,-0.0113791535,0.0019105789,-0.00089962105,-0.015199879,-0.0029501813,-0.084846936,-0.0701388,0.047092963,-0.056867562,-0.06322379,0.01602593,-0.09488355,0.07087555,0.021377595,0.022924693,0.0011118319,-0.08876161,0.0957047,-0.05630016,-0.11400787,0.054251496,0.014641256,0.053196292,0.026326548,-0.01255486,0.06186729,0.0268935,-0.09211969,0.003522759,0.026854785,0.03149429,0.044776104,0.04450973,0.1148022,0.071070656,-0.021937171,0.07564467,0.06666852,0.08773182,-0.026338112,-0.021196416,0.0025121914,0.051714785,-0.037783276,0.015448415,0.04472254,-0.080333285,0.023456257,-0.050758846,-0.102523915,0.021662215,0.073049426,0.033615705,-0.0016822603,-0.052636396,0.018614726,-0.028538909,-0.042626217,-0.004077606,0.010247398,0.049496453,0.029392196,-0.0154109085,0.040872466,-0.14168464,-0.02342855,-0.05432448,-0.041363254,-1.7187792e-33,0.062784,-0.06824454,0.011836889,-0.05801992,-0.0014468896,0.022014258,0.013066561,-0.09883511,-0.030497141,0.029886791,0.14017779,-0.06445263,0.06256695,0.001997709,0.016653832,0.045003187,-0.05226389,-0.008269955,-0.01769475,0.054653466,-0.018955803,-0.052300733,0.032122314,-0.02090799,0.039198805,0.023122437,-0.062279515,-0.030248541,0.11879567,-0.009955285,-0.08507652,0.05345223,-0.058259916,-0.12583712,-0.069281384,0.017167237,-0.020482168,0.059566867,0.04669886,0.021998225,0.013769961,0.021574214,0.01132713,0.08274951,0.026063591,0.11385295,-0.09269617,-0.043499265,-0.037340023,0.045965884,0.078702986,0.0054111015,-0.07325796,0.021629332,0.0016685568,-0.047420353,-0.00076621823,0.073481284,-0.030757,0.004902446,-0.04690848,-0.07033286,0.006963864,0.042418268,0.062488407,0.10828414,-0.026511103,0.12406887,0.00017866863,-0.018835425,0.070323475,0.030851286,0.10255641,0.01509427,0.0016558483,0.0001441929,0.0037718525,-0.0051230877,0.028875634,0.064499505,0.005923704,-0.038074184,-0.054325707,-0.032185312,0.023579344,-0.06543197,-0.032438353,0.02376949,-0.01065877,0.0028549852,-0.07013776,0.052105803,0.0009982897,0.037254777,0.014536021,-3.388002e-08,-0.0451611,-0.06856283,0.016570438,0.012113194,0.044253774,0.011111606,0.028140584,0.012709988,0.036097348,-0.022842754,0.0008472449,0.078089364,0.022793207,-0.045871034,0.026190145,0.016282527,-0.015874939,-0.0014074804,0.069832,0.00411146,-0.033610776,0.025130047,-0.009904784,0.04059589,0.039169565,-0.12101719,0.0070380103,-0.04758375,0.06746969,-0.01401368,-0.017056804,0.08173225,-0.032312207,-0.008292442,-0.048663877,0.00068145414,-0.0567245,-0.027215991,-0.062487535,0.026031991,-0.038699895,-0.009171975,-0.13115531,-0.048885386,-0.0285576,-0.0028645408,0.026905753,0.07290987,-0.045390785,-0.04514493,0.005190162,0.016847601,0.03594021,-0.028741958,-0.0765951,0.040603995,0.08661121,-0.05316639,-0.04083673,-0.038558014,-0.0076604337,-0.042941663,0.13827293,0.013783712 +1.14.14.134,A cytochrome P-450 (heme-thiolate) protein. Found in plants and participates in the biosynthesis of soybean saponins.,384,1.0,-0.09994525,0.02028135,-0.054527387,0.0012369271,0.07295638,0.09481429,-0.035173506,0.10643621,0.050668526,-0.00996154,0.10782605,-0.008345341,-0.04230064,-0.05951703,-0.013168337,0.02433119,-0.033500735,0.051859155,0.008605793,-0.07616573,-0.009596847,0.0781009,-0.020019505,0.007255433,0.03275616,-0.03561893,0.023578469,0.021897653,-0.011996991,-0.01645893,-0.09039068,-0.03341384,0.07002264,0.021019876,-0.021244014,0.14148736,0.004678305,-0.12142214,0.08431457,-0.06407722,0.09486096,-0.02318859,-0.03964039,-0.02442491,-0.008369769,-0.009730181,0.00805092,0.0013453877,0.05055463,-0.09505387,-0.006178599,-0.02504524,-0.0072065582,0.014004992,-0.0074193333,-0.050990067,0.07038732,-0.0002631394,-0.022632139,0.004423843,-0.041650917,0.042889122,0.011821764,-0.013936445,0.018210184,-0.06344022,-0.0550816,0.028598003,0.0136143835,-0.0359058,0.0144292535,-0.064978555,-0.019059377,0.02983654,-0.13927244,0.103001595,-0.048671503,0.052719425,-0.011368202,-0.013558189,0.05862618,-0.0073560006,0.005900575,0.12676881,-0.003281479,-0.021372663,-0.021992885,0.111895576,-0.037873995,0.0072142794,-0.018548146,0.023968084,-0.010541879,-0.0015295947,-0.08700207,0.04289807,0.047043197,-0.025574224,-0.005930755,-0.020235434,0.057825174,0.039914776,0.015870363,-0.10739857,-0.09367551,0.040895727,-0.040194582,0.030014873,0.100204445,-0.06215616,-0.048321214,-0.02653026,-0.050180092,0.030965116,-0.030476494,0.06543899,-0.004738679,-0.0042783567,-0.023062093,-0.0086750025,-0.010215019,0.027979998,0.04185954,0.031422723,-0.0077786883,-0.02277,-0.10006394,1.921858e-34,0.10336589,0.013257367,-0.030112946,-0.019356718,-0.0026375304,0.0071161343,-0.0918952,0.027610593,0.008561009,-0.0483336,-0.107945874,-0.08174468,0.031228095,-0.021859717,-0.01631629,0.00301238,-0.08524065,0.009117936,0.11353226,0.00135569,-0.1011921,-0.04428482,-0.056063607,-0.010382882,-0.0130653605,0.06083483,-0.011756366,-0.06620935,-0.013925977,0.000246725,-0.033074662,-0.07260839,-0.04807702,-0.011041171,0.054039806,-0.03699451,0.007569077,-0.025994824,-0.12998375,0.047324635,-0.014079851,-0.019007562,0.017095873,-0.035371434,0.06792002,-0.009336869,-0.09490713,0.04401108,0.0008112959,0.049563088,-0.0016709617,-0.039476603,0.11414291,0.010454737,-0.019736936,-0.024875531,0.047537733,0.046341237,-0.03813669,0.057507172,0.083346955,0.038392648,-0.029859204,0.052043512,0.009780088,0.10089378,-0.08772718,-0.037363034,0.041195277,0.10652146,-0.003406084,-0.07161014,0.046871934,-0.0017415303,0.013871865,0.0041942345,-0.011263082,0.06483092,-0.00018087307,0.07719143,0.014681099,-0.023558568,-0.020773506,-0.029874282,-0.011638202,0.06553608,0.011467246,-0.02730746,-0.003093056,0.006505375,0.08822588,-0.053128317,-0.042451035,0.0058098687,-0.049646337,-6.8699742e-34,0.030789772,-0.02153686,0.012982095,-0.056123704,-0.03281512,-0.009744565,-0.023967061,-0.013100086,-0.012611502,-0.0067307893,0.0778384,-0.09764706,-0.00926501,-0.00029289685,0.020266226,0.039096337,-0.035707157,0.04390835,-0.013297663,0.050968487,-0.011210336,-0.001632536,0.059515752,0.031874366,0.04511049,0.024928128,0.008452539,0.005740357,0.011348171,-0.015103237,-0.013489365,-0.01906006,-0.07518108,-0.04601546,0.019798243,0.019169802,0.021456871,-0.0074249026,0.06993107,0.088179074,-0.02189444,0.09863256,0.023404587,0.04246549,-0.0002473252,0.074251324,-0.0570196,-0.0081640165,-0.049483344,-0.00508075,0.050514404,0.015894772,0.021805655,0.060257655,-0.046354126,-0.021184688,-0.023178503,0.10924382,-0.03388399,-0.011984077,0.030879179,-0.08213808,-0.0137774395,0.0747375,0.014283307,0.04936315,-0.028508266,0.0599653,0.007092086,0.011058827,0.053499874,-0.027103016,0.08156512,0.10016333,-0.008818247,0.023972373,0.025769174,-0.052528616,0.014175278,0.019851984,-0.0022990063,0.041963197,-0.08121861,-0.057882432,-0.017291049,-0.002233122,-0.068384185,0.13444541,0.060286883,-0.013839622,-0.025083266,0.07413923,-0.043075964,0.08310315,0.06236821,-2.5935606e-08,-0.03136567,-0.107125096,-0.024758242,0.0069067525,0.062861815,0.017695911,-0.026316026,0.019297568,0.05214663,-0.025743278,-0.016288867,0.06820477,-0.07856439,-0.011370872,0.0006402752,-0.04161722,0.06281403,0.056119427,0.03495306,0.022194838,-0.018405108,-0.022156853,-0.08246175,0.0037491696,0.033096828,-0.12537603,-0.031437106,0.014459933,0.054577574,-0.008014227,0.03262925,0.046273235,-0.05344146,-0.074152276,0.024597703,0.068891294,-0.098398246,-0.06942749,-0.034760397,-0.025022687,-0.02726717,-0.028666291,-0.048097163,-0.019188546,-0.00419486,-0.047663935,0.06768669,0.093935736,-0.040519554,-0.012500799,-0.035625253,-0.024794012,0.04171668,-0.083518155,-0.069228955,-0.046978068,0.09428545,-0.029968917,-0.029111778,-0.062156048,-0.034850404,0.022501407,0.17037651,-0.025364667 +1.14.14.135,A cytochrome P-450 (heme-thiolate) protein purified from soybean.,384,1.0,-0.08380788,-0.0019799185,-0.04355245,-0.05867024,0.0726235,0.08242163,-0.036580246,0.08894645,0.023478955,-0.016283656,0.08096238,-0.0007513265,-0.008582099,-0.09068475,0.0019814647,0.0036559722,0.029779242,0.025942203,0.01227946,-0.095852435,0.005995431,0.04234696,-0.022673221,-0.020401279,0.021007484,-0.025045443,0.05818246,-0.0234939,-0.050511397,-0.03278999,-0.03231589,-0.048340876,0.05260098,-0.0085923495,-0.017161466,0.12186206,-0.03781601,-0.1213851,0.034645777,-0.07502347,0.05291881,-0.010013282,-0.033865225,-0.035604276,-0.012962196,-0.04225775,-0.019826151,0.041661777,0.08560261,-0.0952948,0.0034970304,-0.03605587,0.0250543,-0.017376073,-0.021792974,-0.025098916,0.023342049,-0.0010847246,-0.03848963,0.034778044,-0.10894459,0.06337284,0.019543156,-0.01119912,0.034543436,-0.041485358,-0.038581327,0.014068335,-0.01250172,-0.0051487186,0.017498778,-0.0507535,0.009112712,-0.012377457,-0.10906763,0.07483769,-0.050041504,0.0386924,0.029054383,0.03344758,0.006880269,-0.033459056,0.045217246,0.08154574,-0.03357491,0.0107053965,-0.054866046,0.08006651,-0.07524621,0.02165937,0.011890387,0.03812552,0.017578948,0.050470646,-0.037787084,0.04351551,0.035052933,0.0029602223,0.023728484,-0.023525624,0.06415125,0.016996296,-0.012639267,-0.13063836,-0.070595115,0.05263192,-0.01242542,0.05473232,0.08449676,-0.04655562,-0.04338235,0.017043019,-0.049213864,0.0050252303,-0.036897574,0.058873795,0.04869689,-0.0028257493,-0.032576967,-0.027831122,-0.0050147646,0.056818474,0.058049176,-0.013413296,-0.015366826,-0.011344385,-0.04123932,4.9518397e-34,0.09385262,-0.035313684,0.0020565097,-0.015844177,-0.031405106,0.037249114,-0.06785328,0.026005864,0.052550796,-0.039194994,-0.10949544,-0.076092705,-0.027339928,-0.028021662,-0.018069118,0.0013691825,-0.08314532,-0.008771541,0.07772884,0.016019577,-0.07769375,-0.028528638,-0.014225435,0.019178377,0.00460362,0.047934532,-0.017444484,-0.06306497,-0.029525608,0.008887293,-0.07343193,-0.08898277,-0.064164035,-0.028664034,0.007947855,-0.005190835,0.05213264,0.010449132,-0.13610196,0.061855923,0.008122029,-0.059479482,0.041536678,-0.05680571,0.05428622,0.015661787,-0.048430383,0.032070488,-0.041832905,0.047999047,-0.03047479,-0.054992013,0.077375636,-0.035078052,-0.012193264,-0.016304562,0.06307165,0.07650455,-0.025851252,0.04978766,0.045939945,0.12555799,-0.008378609,0.060789216,-0.014316836,0.063069426,-0.07013598,-0.038974036,0.026234882,0.09826488,-0.028415821,-0.0095515875,0.073117204,-0.040140364,0.04675788,-0.05053757,-0.021139964,0.03860317,0.044676065,0.08662655,0.079089455,-0.021164447,-0.0017996423,-0.002447241,-0.00864354,0.06964592,0.011164996,0.00047773635,0.024502045,0.033312473,0.08953089,-0.049939528,-0.03874118,0.00550057,-0.048718143,-1.1784716e-33,0.04904148,-0.041757576,0.053901006,0.015964404,-0.0128285745,-0.009303518,0.026425363,0.029945066,0.024473732,-0.03897605,0.0645151,-0.10812492,-0.040219456,-0.01875687,-0.0126141235,0.059452336,-0.07280047,0.043777652,-0.06605371,0.037954733,-0.09651544,-0.031579524,0.09293485,0.008397799,0.058932025,0.03698861,0.04321869,0.020431153,0.01977124,-0.025264807,0.011106147,-0.0072538303,-0.07011908,-0.04055629,-0.021835001,-0.005016703,0.0065547177,0.001639913,0.095147595,0.054326016,-0.025638476,0.081847735,-0.010549022,-0.005742432,-0.0440984,0.06932567,-0.077515654,-0.052210443,-0.038041748,-0.011196334,0.042100765,0.012667378,0.03212138,0.04881701,-0.036367003,-0.05150824,-0.007490612,0.09780147,-0.018584678,0.040321704,0.018107282,-0.061881665,-0.0076385275,0.09747788,0.036789615,0.05178872,-0.007994819,0.05926606,0.016868003,0.033264402,0.038105674,-0.003445315,0.0834749,0.10164034,0.054398812,0.021571932,0.013431413,-0.01483808,0.043063644,0.010071622,0.032945715,0.022321636,-0.10324934,-0.07331996,0.032443102,0.014594942,-0.07638027,0.09351021,0.07067281,-0.014089205,-0.028765718,0.056831274,-0.07342253,0.037701715,0.057430066,-2.2403421e-08,0.005337504,-0.0758674,-0.029298447,-0.007270827,0.068098396,0.036661316,-0.0017171666,-0.010642915,0.07738017,-0.03153432,-0.016959727,0.081231244,-0.09790403,0.018666267,-0.031910114,-0.067211136,0.03607853,0.06040971,0.07259898,0.01742161,-0.036375392,-0.006864321,-0.08841465,-0.023149647,0.060165107,-0.08147854,-0.016745416,0.022838995,0.11419286,0.0013827324,-0.018041644,0.031243475,-0.086874105,-0.07227028,0.045218624,0.023289986,-0.09895761,-0.047728192,-0.044229407,0.016955722,-0.03350958,-0.0022756262,-0.051811334,-0.042640194,-0.024756962,-0.08392296,0.057020746,0.12552708,-0.049231205,-0.009177948,-0.041119877,-0.028251374,0.011114398,-0.09579739,-0.056175664,-0.039845724,0.11108663,-0.06720203,-0.04298275,-0.10021257,-0.03667569,-0.032429866,0.11380894,-0.0033959823 +1.14.14.136,A cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina.,384,0.9999999,-0.07758049,0.062849835,-0.05667702,-0.0030889048,0.052954607,0.08570794,-0.023522904,0.05154789,-0.027715,0.017022658,0.022865042,-0.030831043,-0.00031127356,-0.04492308,-0.061330676,0.024946325,0.02928285,0.044714056,-0.006379206,-0.07106444,0.026618456,0.08753017,-0.045141265,0.0073584556,0.047384117,-0.020006288,-0.061238673,0.056268234,-0.022532025,-0.029362975,-0.07664508,0.011370185,0.012790446,-0.024919126,0.04912417,0.077824615,-0.09740115,-0.09793248,0.013129498,-0.014168761,0.13347287,0.0014857226,-0.04798564,0.02461615,-0.06433882,0.043221507,0.022239605,0.017998507,0.06005816,-0.0556384,-0.0221962,0.0133568775,-0.051204152,0.02464863,-0.10833374,-0.041990675,0.03771479,0.030336907,0.005814631,-0.03187384,0.0056862915,0.058473077,-0.025620786,0.031413313,-0.009720236,-0.07582428,-0.07119965,0.028098544,-0.009382465,-0.012422014,0.015471255,-0.0058316644,-0.017330652,0.05175106,-0.02444299,0.11323848,0.017490365,0.009884687,-0.027755488,0.011459458,0.012738334,0.060774848,0.092839114,0.05082691,0.05115929,0.04525462,-0.0114495,0.10628216,-0.08647015,-0.05779927,0.05675454,0.024358004,0.039928157,-0.026555013,-0.04469714,0.0738095,0.064420044,-0.053335074,0.0222613,-0.03010915,0.010582995,0.00075866445,0.049658973,-0.046747647,-0.055510413,0.0254552,-0.05321507,-0.039285082,0.06462478,-0.01309668,-0.037307944,-0.03336052,-0.01880181,-0.037033636,0.01819011,0.053627055,-0.040774498,-0.001242116,0.011622119,-0.11155625,-0.023095416,-0.047945354,0.04432081,-0.0008691281,0.005962049,0.011485407,-0.15301839,1.1497366e-33,0.04215109,-0.0019759482,-0.009878722,0.0089045465,0.006196319,-0.004578109,-0.0375933,0.054150578,-0.026828963,0.015743533,-0.10706155,-0.07722023,0.038836893,-0.08274795,-0.097183995,-0.00966623,-0.029792693,0.011503691,0.027896771,-0.034960646,-0.020280909,0.038037777,-0.018274857,0.025733646,-0.017553838,0.04292024,-0.013404699,-0.073076725,0.05892073,-0.00898031,-0.049804624,-0.06812037,-0.041652095,-0.010765403,0.015340217,-0.020542728,-0.046090167,-0.088243514,-0.050215606,0.040846307,-0.017831631,0.03561589,0.06487714,-0.07043383,0.06715502,-0.014100377,-0.0973259,-0.042118754,-0.017090388,0.014275786,-0.0066105244,-0.023037715,0.12798083,0.054301377,-0.11384166,-0.014860873,0.0038976183,0.029941289,0.030182675,0.026650013,0.06156598,0.028170347,-0.0542031,0.004713876,0.030190632,0.077829145,-0.081573404,-0.030114869,0.01870806,0.091937765,0.005079999,0.00025769894,0.080645606,-0.029303778,0.10866281,-0.00042235485,0.042167775,0.048650492,-0.015688377,0.07630829,0.03312586,-0.011021949,-0.0140007185,-0.0019099616,0.037019685,-0.013887379,0.091621086,-0.014590283,0.043978106,0.028343871,0.095221035,-0.10713556,-0.035568934,0.046025317,-0.039398894,-2.8525793e-34,0.07722048,-0.0008549084,0.07062422,-0.025897514,-0.014540707,0.02806434,-0.020985443,0.0061716824,-0.038574755,-0.018136995,0.14025061,-0.044317935,-0.005303599,-0.0051035355,0.014420729,0.004374249,0.020096488,0.03131681,-0.009530755,0.098608665,-0.10328535,-0.012826267,0.0072114654,-0.058376968,0.051706575,-0.047766887,0.036996514,-0.014370889,0.03384963,-0.03439559,-0.04373697,0.09051729,-0.08809729,-0.08930449,-0.03216136,-0.012078249,-0.066640235,-0.011246859,0.06456955,0.058070038,0.02470729,0.049176898,-0.02229171,0.03128874,0.06482428,0.10390461,-0.045228016,0.0016438403,-0.023620207,0.018962627,0.07126113,-0.04688186,0.0064888373,-0.02144209,0.010490475,0.004508731,0.050355796,0.09682685,-0.011037688,-0.030676218,0.04205401,-0.014473302,-0.026408361,0.071672626,-0.0046120114,0.17206317,-0.026159778,0.031706855,-0.039634585,0.06289716,-0.022753835,0.023350717,0.08300043,0.05788939,0.02793493,-0.019114582,-0.015443625,-0.015281142,0.013155696,0.03237591,0.025721405,0.005491817,-0.05179783,-0.06775935,0.037310254,-0.033650473,-0.03396066,0.12903081,0.013891095,-0.05689495,-0.057101984,0.037788842,-0.0042025005,0.09088891,0.13121875,-2.4388562e-08,-0.0031414719,-0.068131834,-0.042713407,-0.07365387,-0.0087640695,-0.0028224569,0.031657342,-0.025509588,0.009617637,0.056455273,0.009499465,-0.00987539,-0.03825029,-0.03455511,-0.016230613,0.06885629,0.00512108,-0.00531368,0.07505184,0.044692237,-0.0071763946,0.04298548,-0.023759311,0.019778525,0.0008454983,-0.08795317,0.03816558,-0.055764932,0.034338046,-0.083165884,0.038671017,0.03268594,-0.0057802047,-0.0014030315,0.006213414,0.016481182,-0.08045382,-0.02183872,0.03425877,-0.05330205,0.033789385,0.011431773,-0.019912729,-0.033298198,-0.0010094369,-0.0151376,0.05015937,0.015462269,-0.031584278,-0.1160292,-0.03943624,0.027153874,0.046730556,-0.14805797,-0.052900184,-0.050774585,0.0701845,-0.019971149,-0.061892707,-0.05149271,-0.054867644,-0.04521709,0.14078751,0.013179825 +1.14.14.137,"A cytochrome P-450 (heme-thiolate) protein found in plants. Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone [1]. CO inhibits the reaction, but its effects can be reversed by the presence of blue light [1]. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously.",384,0.9999999,-0.08995277,0.010948966,-0.05819674,0.021182802,0.13236359,0.10540968,-0.03131576,0.0904217,0.012827667,0.014103034,0.06309624,0.018657621,-0.027846172,-0.04481625,-0.066888064,0.07666943,-0.06721051,0.004300312,-0.022655554,-0.073649496,0.017834188,0.0032217617,-0.05510503,0.038983725,0.019369988,-0.02355862,-0.023193,-0.015976485,-0.041707043,-0.06799571,-0.069633216,0.026094124,0.05243467,0.024417587,0.0006708296,0.07426624,-0.0052336105,-0.13289158,0.103009254,-0.024538841,0.046565328,-0.021251319,-0.06275036,-0.002921842,-0.026355073,-0.00038261566,0.019359332,0.009333128,-0.001741407,-0.07314328,0.003971144,-0.01573222,-0.03360659,-0.008435196,-0.115475975,-0.011763475,0.024554424,0.06255552,0.033501785,0.040835768,-0.0073318803,0.028389238,0.00062213297,0.034386,0.018460019,-0.03120044,-0.051871408,-0.032289535,0.005349256,-0.02511647,-0.014133158,-0.09476901,-0.034321092,-0.028795332,-0.034679614,0.076376215,-0.055912226,-0.046149924,-0.022857971,-0.013617089,0.05041083,-0.015712874,-0.02269966,0.099685036,0.04535314,-0.023201533,-0.019227527,0.03483134,-0.04358554,-0.022773096,-0.028543225,0.04469282,-0.0041694134,0.028328972,-0.09410067,0.117993526,0.07580849,-0.07250904,0.0071281698,-0.028674837,0.0060453834,0.09991471,-0.04694561,-0.10395487,-0.074664235,-0.02049221,-0.004190584,0.08171058,0.05475362,-0.0076052197,-0.072022445,-0.017555213,-0.00051196193,-0.03039043,0.035688292,0.121187285,0.04584093,-0.018888993,-0.0340773,-0.085795954,-0.004065665,-0.03737787,0.010205652,0.027085725,-0.05149737,0.017059617,-0.056667738,2.3958509e-33,0.08775342,0.02834644,-0.04251161,-0.027399566,-0.028326342,-0.0148695875,-0.06600518,0.018321652,-0.016430475,-0.036663387,-0.03373692,-0.08196207,0.013964892,-0.029352179,-0.008702727,-0.04692313,-0.022382941,0.0064308327,0.07322102,0.027245983,-0.059657134,0.0085259015,-0.081760466,0.00087849185,0.013719505,0.086528584,-0.001399844,0.008775941,-0.0022954834,-0.024096776,0.026623517,0.0029361225,-0.111572914,0.026574247,0.0342512,-0.06810855,-0.008539474,0.011002598,-0.062354736,0.08869023,-0.04714656,0.03365518,0.049151294,-0.078636415,0.10358711,-0.03732871,-0.06924857,0.09667354,0.028622167,0.059134524,0.009447825,0.017138107,0.123357125,0.02462567,-0.025497135,0.020729436,0.019801544,-0.0036296658,-0.020864094,0.038915,0.13436195,0.028798565,-0.041204676,0.025277628,-0.023489166,0.025938442,-0.10269368,-0.063595906,0.0281893,0.09839104,-0.086455084,-0.030085118,0.03225743,-0.020658074,0.057097718,-0.029982662,-0.023377154,0.11538691,-7.006687e-05,0.06646177,0.019396875,-0.030077685,0.022359923,-0.029151069,0.02309608,0.029621687,0.050998572,-0.015370232,-0.03182372,0.017153563,0.08193457,-0.06075226,0.025990045,0.02678669,-0.033549514,-2.0183313e-33,0.087573536,-0.061793573,0.001146826,-0.074182004,-0.037161004,0.0113934865,-0.029514357,-0.02632615,-0.0013954552,-0.0016378032,0.10800899,0.0012705654,0.01756797,-0.002805176,0.051408812,-0.026295405,0.0011216436,0.04922076,-0.006437665,0.05486709,-0.02710619,0.08344913,0.035842367,0.0085494835,0.061084766,0.017824221,-0.004141875,0.03338309,0.048015956,0.029442592,-0.05180463,0.053060107,-0.06582713,0.021342747,-0.008865171,0.033887014,-0.0627167,-0.043416217,-0.012226962,0.038700186,0.0015364371,0.03419164,-0.034871202,0.010942845,0.06895892,0.06283686,-0.08197001,0.01954184,-0.0031778128,0.016096905,0.048006512,-0.00022898619,-0.052772958,-0.0019240548,0.04880025,-0.0067638597,-0.024072386,0.03671176,-0.030170767,-0.03285463,-0.013426492,-0.018160565,0.0027618532,0.051028144,0.0034582673,0.0975191,-0.019705003,0.0859308,0.007012872,0.028208667,0.103578,0.06417456,0.03211087,0.084840536,0.003930958,-0.042178698,-0.01420753,-0.010268378,-0.06523091,0.0070503396,-0.03783923,0.014772819,-0.051964436,-0.10041304,-0.0025762103,-0.096269354,-0.13602494,0.09596137,0.03626967,-0.0174194,-0.034780648,-0.010847069,-0.009473812,0.06696318,0.07041445,-4.2547565e-08,-0.019355578,-0.051855125,0.038207587,-0.040595166,0.043307714,-0.02303464,0.0370754,-0.043619078,0.048378933,-0.042387098,-0.047170427,0.08512215,0.0126469955,0.005918154,-0.023920333,-0.01761653,0.026604176,0.041969117,0.043654516,0.06826969,-0.07139888,-0.04124675,-0.08077708,0.033498123,0.055570453,-0.07798919,0.053821582,-0.0132657755,0.049957205,0.0286438,0.059343547,0.056447662,0.062281948,0.0075323144,0.0148417605,0.02308697,-0.017923633,0.0039490503,-0.07526901,-0.0030492465,-0.04601538,-0.015955955,-0.111595966,-0.024107587,0.0410572,-0.023255264,0.053695153,0.034267742,0.007091167,-0.006193518,0.0100683,-0.025866088,0.019816836,-0.10123564,-0.048402816,-0.049245287,0.091144346,-0.043009564,-0.04256005,-0.056354858,-0.0084428135,0.008632408,0.21974714,-0.06033844 +1.14.14.138,A cytochrome P-450 (heme-thiolate) protein from Mesocricetus auratus (golden hamster). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters [1].,384,1.0,-0.017417958,0.08922175,0.037204616,-0.01015429,0.02463936,0.037295893,0.064160965,0.07173291,-0.0021511656,0.07227971,-0.06424475,-0.053921554,-0.037324347,0.022553166,-0.06958191,0.03590376,-0.02635407,-0.022678414,0.037642475,-0.04093968,0.0017346807,-0.006373051,0.017783126,-0.034978542,-0.035895403,0.00931413,0.009341937,0.07665405,-0.041101288,-0.0032801996,-0.055727817,-0.09094812,0.09195771,-0.013486046,-0.042198323,0.09336571,-0.03579421,-0.046994895,0.044208422,-0.0016802633,0.06501213,-0.036323346,-0.092071235,0.038171288,-0.034253377,0.014836355,-0.0033785412,-0.028310781,0.009180113,0.040400404,-0.04983105,-0.063051954,-0.012473924,0.078627534,-0.0541288,0.0019482189,-0.03421573,-0.00513412,0.015746098,-0.04880775,-0.069015466,0.069786325,-0.001761895,-0.0098304255,0.022195458,-0.054903157,0.0058215237,0.045432642,-0.02451066,-0.057819724,0.035452873,-0.03400017,-0.046924748,0.0011998586,-0.07906194,0.060783394,-0.024769776,-0.030495174,0.048080776,-0.031243633,-0.012120891,0.0019417845,0.0049444623,0.07798232,0.023675255,0.00025717242,-0.042748623,0.017132288,-0.098343045,0.017371582,-0.024301317,-0.044087708,-0.02658623,-0.009873868,-0.05587327,0.013505493,0.08968903,0.0035733115,0.053135116,-0.004071745,0.05290275,0.03839723,0.039779514,-0.09610093,-0.082398124,0.015776033,-0.040097874,0.05984777,0.07835573,-0.07282915,-0.11461212,-0.045078877,-0.0054816576,0.02539497,0.034980442,0.111510195,-0.029764635,0.021758862,0.013235808,-0.02874547,0.011840084,0.03144044,0.045679536,0.05753568,-0.04774516,0.018437771,-0.10602038,1.4271177e-33,0.020311123,0.0371495,0.009543128,0.04940114,-0.030182296,0.05701109,-0.03648989,0.08983748,-0.0650164,-0.027080184,-0.094635636,-0.07486084,0.033027932,-0.0685794,-0.003128076,0.034344874,-0.052089017,-0.020463498,0.052465614,0.044146575,-0.11389574,0.012078102,-0.0060061854,-0.043788135,0.057336766,0.0074661593,-0.031043453,-0.008928204,0.022580264,0.0075573507,0.014247615,-0.031020274,-0.028144782,-0.042009093,-0.012970403,-0.011222631,0.006003635,-0.047399394,-0.057986524,0.018848095,0.024546763,-0.07987671,0.024901716,-0.09392284,0.07147406,-0.042776063,-0.12260005,0.010968486,-0.018485198,0.021152142,0.040155582,0.01913576,0.08456709,-0.029986525,-0.08675573,0.068353854,0.0012695681,0.07779195,-0.0522808,0.11955273,0.08985078,0.047891025,-0.0017128338,0.031889852,0.02099814,-0.023077825,-0.059018996,-0.018031286,-0.06924516,0.16281672,-0.01687529,-0.0007639598,0.046116598,-0.101836376,-0.0017212208,-0.013097728,-0.02578068,0.11645721,0.012310083,-0.006391844,0.008696206,0.08198826,-0.063297115,-0.036987387,-0.0017040073,0.027745245,0.11564793,0.008704209,0.01388816,0.07729699,0.083046585,-0.1325396,-0.08612807,-0.018439533,-0.012407257,-2.8267486e-33,-0.015065397,-0.056776255,0.0038003863,-0.03040894,-0.03682998,0.093811005,0.057202987,0.004148753,-0.041041523,-0.032204688,0.1327939,-0.044854634,-0.007405509,-0.02469388,0.027754784,-0.01116605,-0.07829427,0.05801799,0.011221141,-0.01668138,-0.009122467,-0.014221003,0.028873468,0.029330488,-0.004597739,-0.022573223,0.021503186,0.034967102,0.08276003,0.03700074,-0.034538787,0.070274875,-0.08155159,-0.052712914,0.04373125,-0.012905004,-0.007926635,-0.0058055324,0.050703466,0.043054737,-0.0030339207,0.07673946,-0.0038886608,0.059104253,0.03350052,0.19008641,-0.04655142,-0.01972144,0.015557323,0.020277364,0.01349068,-0.063342184,-0.043318942,-0.028428847,-0.0027782023,-0.005533239,-0.042810526,0.003234836,0.03671462,-0.060098536,-0.03832176,0.02297618,-0.022140086,0.046490718,-0.0043565687,-0.0009229767,-0.044281416,0.006234193,0.0010895847,-0.011875128,0.085377924,-0.018860757,0.046436332,0.041121826,-0.004536222,-0.021730384,0.04053045,0.0031987324,0.021281393,-0.024957232,0.05763665,0.030390266,-0.020810064,-0.051190276,-0.027201818,-0.051974475,-0.027440824,0.16496916,-0.021142378,-0.026315182,-0.008635037,0.11996149,-0.09265707,-0.016546585,0.04777874,-3.5632684e-08,0.017544521,-0.12634474,-0.021408293,-0.044512607,0.036542002,0.0557571,0.0005819387,-0.02196494,0.006971608,0.013820672,0.009583786,0.02258871,-0.00024245918,-0.019470736,-0.021744935,0.021348424,0.008314975,0.01697766,0.06689443,0.05242791,-0.03316944,0.030884936,-0.00071739434,0.0458057,0.04149909,-0.11708445,0.021624854,0.011410556,-0.002626346,-0.03725313,-0.03139274,0.06904205,-0.031095194,-0.012500983,0.041576117,0.032881644,-0.071802914,-0.01426883,-0.03437042,-0.024719594,0.02832427,-0.047209203,-0.04031814,-0.060609736,0.036123317,-0.020493802,0.04590509,0.03168007,-0.02341,-0.042651396,-0.11077056,-0.0106872255,0.064397566,-0.08459408,-0.081704326,-0.053018108,-0.0040019765,-0.06387121,-0.0045916624,-0.08241802,0.045822583,0.02400433,0.1551761,-0.032958146 +1.14.14.139,"A cytochrome P-450 (heme-thiolate) protein found in mammals. This is the key enzyme in the biosynthesis of the bile acid cholate. The enzyme can also hydroxylate 5beta-cholestane-3alpha,7alpha-diol at the 25 and 26 position, but to a lesser extent [2].",384,1.0,-0.02620009,-0.046027552,-0.04644914,-0.03995623,3.678931e-05,0.04566673,-0.017041566,0.0702036,-0.027863821,0.011246145,0.013984801,-0.0048613334,-0.09115118,0.03600418,-0.037579637,0.043152645,-0.06037894,-0.0017340257,0.008891334,-0.10237136,0.014740592,0.0018789121,0.03294588,0.02480421,-0.015052002,-0.0049579195,0.12255191,0.002605337,-0.035384808,-0.06763644,-0.066950515,-0.06762948,0.09855688,-0.033060554,-0.029727435,0.073217936,-0.059614204,-0.0252958,0.04999643,-0.025226487,0.08976816,0.010670103,-0.043802515,0.0070994473,0.00079524674,-0.049902666,0.0043367282,-0.011678199,0.032079794,0.028574761,-0.0457658,-0.0018867245,-0.03760499,0.01037388,-0.023626493,0.033824477,0.0057236427,-0.08105704,0.053990804,-0.045189418,-0.041836597,0.05532934,0.003964111,-0.03615942,0.020638045,-0.053328674,0.011616606,-0.06057548,-0.01457646,-0.07707332,-0.056856867,-0.089591935,-0.046336263,0.044179868,-0.088599786,0.054096624,-0.043219432,-0.039228022,0.021258455,-0.020219363,0.0025144329,-0.036480464,-0.008775463,0.12902096,0.08689333,-0.025136743,-0.025969267,0.04153818,-0.051532917,-0.05662686,-0.047224402,-0.0007468035,-0.06802825,-0.047676317,-0.05307282,0.004807293,0.037771486,0.0026372843,0.02603987,-0.0075492933,0.101815455,0.07176766,0.026426274,-0.118617676,-0.05695944,0.01251472,-0.015644167,0.08387726,0.08273271,-0.07580929,-0.03885504,-0.004678713,0.053274438,-0.054354962,-0.0090225125,0.138927,-0.0699095,-0.051043827,0.017400851,0.064552926,-0.03259051,0.04638997,0.01919156,0.05149394,-0.030438926,0.022411114,-0.06370802,7.433633e-34,0.06477323,0.002071891,0.022981223,0.017713698,-0.00528253,0.024524724,-0.024400461,0.014617564,-0.012725592,-0.037289478,0.013926403,-0.055689774,0.03167421,-0.053181022,-0.033316817,0.006742085,-0.018263035,0.026416907,0.05201774,0.039012045,-0.06761704,0.012984492,-0.052836273,-0.0402386,0.05328666,0.05326292,-0.040759586,0.009349583,0.031452306,0.0378702,-0.056702502,-0.040838465,-0.01894758,0.0037872938,0.009717195,-0.039150946,-0.03527547,-0.008874848,-0.050036814,0.06408568,0.09731457,-0.09205092,0.0028915617,-0.042924974,0.043524966,-0.014356024,-0.069336936,0.038671475,0.00415634,0.033571135,0.05672638,-0.050762765,0.08248432,0.03547919,-0.039487556,-0.01931499,0.0010526063,0.035823256,0.03623463,0.081109926,0.09324145,0.111455455,-0.09364044,0.0720533,0.020193078,-0.0009050496,-0.06279136,-0.050209004,-0.07869776,0.11047791,-0.066473566,-0.019222334,0.040741313,-0.018254563,-0.017232597,-0.017142333,-0.014244536,0.08965275,0.016456489,-0.016921038,-0.006157691,0.018975293,-0.015363288,-0.034087073,-0.019981908,0.017446317,0.0108750155,-0.06585731,-0.06416981,0.03797547,-0.007865186,-0.041888617,-0.06158536,0.031307597,0.033662487,-2.5161451e-33,0.01820324,-0.0717173,0.021486824,-0.052763693,-0.04637181,0.082225956,0.07784854,-0.054365568,0.034376346,-0.019115875,0.07436278,-0.049452174,0.046233695,-0.060301024,0.054399647,0.05139933,-0.0015779601,0.06685822,0.01782566,0.014731664,-0.019806033,0.05881779,0.028189726,0.06800265,0.04935856,0.05150873,0.0052307267,-0.021447066,0.08405909,0.061139036,-0.076837644,0.07277166,-0.030759115,-0.040759034,-0.08155372,-0.0066690277,-0.03747755,-0.009787818,0.0177975,0.04001859,-0.08631559,0.092781074,0.089592755,0.050716992,0.011868594,0.09786334,0.018685808,-0.026984314,-0.0056269076,-0.0031913097,0.05555002,-0.024663964,-0.050752256,0.0043413714,-0.02216751,0.085314386,-0.039013013,0.026062643,0.048567116,-0.119480304,-0.094146535,0.021456473,0.035867378,0.034733523,0.005228343,0.06024326,-0.034842115,0.02206399,-0.017165039,-0.0048541003,0.016236054,0.01752173,0.049101252,0.105376095,0.028075546,0.055773,-0.009606099,0.015814397,0.038928054,-0.021829374,0.010589399,0.031110084,-0.039283626,-0.066718526,0.0027423878,-0.10206096,-0.10579852,0.10621162,0.07250064,0.0073641236,-0.030276742,0.01374688,-0.11067472,-0.015051078,0.03438741,-3.9829526e-08,0.03159598,-0.098843016,-0.0358685,0.021746226,0.009755205,0.017215388,0.015176315,-0.01756371,0.068579316,-0.039986774,-0.0059256908,0.10182941,-0.0195894,-0.0022853587,-0.01973866,0.055267338,-0.0034795622,0.027811797,0.033295557,0.025917731,-0.064932026,0.0045172987,-0.006273239,0.051260725,0.006541294,-0.08377729,-0.0031324595,-0.003960259,0.0030705968,-0.025805887,0.0030452663,0.020505564,-0.062289793,-0.04458031,0.046405748,0.03198947,-0.048687115,-0.0348872,-0.0126036825,0.045408208,0.025128497,-0.059898343,-0.059314057,-0.028108804,0.00936641,-0.022676256,-0.011880624,0.055372227,-0.002573155,-0.034552895,-0.103677176,-0.016281102,0.012942677,-0.084036075,-0.041946933,-0.00017741817,0.079736575,-0.13347557,-0.05677851,-0.082696296,0.016574312,0.068625554,0.223331,-0.040202223 +1.14.14.140,"A cytochrome P-450 (heme-thiolate) protein isolated from licorice plants (Glycyrrhiza echinata L.). The immediate product is likely 2-hydroxyliquiritigenin, which spontaneously rearranges to form licodione.",384,0.99999994,-0.06485125,-0.0026716013,-0.064664066,0.018334053,0.025036471,0.10390194,-0.0022029714,0.071447894,-0.014000291,-0.03479231,0.08243323,0.00097136956,-0.023482354,-0.018518988,-0.04561186,-0.0042326595,-0.025523832,-0.021858187,-0.054062616,-0.019142369,0.041765988,0.067643814,0.005820868,0.021686431,0.013685868,-0.026140941,0.011668804,0.07429445,0.041558307,-0.08390439,0.0028672998,-0.013232312,-0.00037506202,-0.043123227,0.035277415,0.061414246,-0.0346841,-0.04812601,0.07110876,-0.011103842,0.14799139,-0.06580589,-0.08547359,0.010733914,-0.03991479,0.020121772,0.0065182745,-0.01765899,-0.0068384097,-0.0033673022,0.013942034,-0.036533795,-0.04470925,0.06345835,-0.04840322,-0.046169978,0.04966011,0.04772878,0.003626584,0.035683915,-0.03954932,0.12836,0.0005106499,0.04255386,-0.048388936,-0.060832582,-0.02265044,0.017080233,0.0013374854,-0.08213038,0.06641078,-0.069165766,-0.013976644,0.059137613,-0.0741056,0.05422773,-0.05003496,-0.03998463,-0.04436841,9.666792e-05,0.055441454,0.013359204,0.0020950404,0.15672596,-0.042833507,-0.0689393,-0.028304612,0.084211186,-0.03649849,-0.06309917,0.024966532,0.015193443,0.0038895078,-0.0005981035,-0.08437875,0.077389985,0.083393894,-0.08667786,0.0037652191,0.013756217,0.015528076,0.032794327,0.044579502,-0.09835505,-0.095124386,0.019724142,-0.06282506,-0.0071082674,0.087218925,-0.07976771,-0.032272536,0.0062126494,-0.013242118,-0.051868197,0.0025705437,0.07646681,0.019198336,-0.031169344,-0.009702246,-0.05451938,-0.021393472,0.0072307303,0.057492156,0.038454816,-0.013479288,0.008555713,-0.05195261,3.180414e-33,0.06440698,-0.017136341,-0.0050863824,0.01577664,-0.018671103,0.0035026132,-0.06356255,0.04052964,-0.044489007,-0.024542546,-0.046511617,-0.06490877,-0.020551886,-0.0056919595,-0.05108258,0.03875132,-0.070669696,0.019429086,0.06618955,0.009932944,-0.03891026,-0.018576462,-0.01633738,-0.0364784,-0.025172878,0.123517856,0.052685376,-0.03643312,0.07073812,-0.0089822365,0.021669002,-0.049599532,-0.060105845,-0.026161611,0.02749916,-0.019512044,-0.059845734,-0.041456662,-0.028313523,0.015620546,0.0015059306,-0.015462807,0.03203032,-0.12453112,0.08789463,0.047075685,-0.13030542,-0.00398075,0.0037001406,0.018427687,0.09225874,-0.0507267,0.08040959,0.07587886,-0.08934931,0.022296026,-0.009065345,0.0072225803,0.009388094,0.039082855,0.16649409,0.0957453,-0.04328322,0.017880665,0.044317607,0.042747885,-0.085764356,-0.042668696,-0.005836428,0.08194877,-0.026237333,-0.090820655,0.056481436,-0.06632101,0.05567918,-0.019805059,-0.06383949,0.070169196,0.001133324,0.056264665,0.012440648,-0.019001193,0.016834132,0.006496778,-0.0385614,0.020199617,0.027395913,0.021792784,-0.04980626,0.029298693,0.08272361,-0.027569877,0.025463272,0.0032486534,-0.0296482,-3.906537e-33,0.07919512,-0.058089886,0.05401214,-0.056660905,0.008289183,0.009830881,-0.033839058,0.008641191,-0.009149619,0.075292654,0.0704172,-0.044549935,0.002932445,-0.050936818,0.022967018,0.018592559,-0.011970431,0.052856512,-0.016010273,0.034243308,-0.05123483,-0.028616836,-0.021793505,0.01715016,0.08164526,0.00017023603,0.062975705,-0.0063420706,0.035056077,-0.006977555,-0.07503137,0.050545588,-0.07055431,-0.06586817,-0.050147712,0.009799185,-0.084512144,-0.047823835,0.022376986,0.003909557,-0.056186967,0.068103835,0.066037014,0.040553845,0.07149878,0.05282897,-0.05750969,-0.035693694,0.012101345,0.037294425,0.033674024,0.015753804,-0.045474216,0.008612644,-0.029101448,0.029094463,-0.043069422,0.0670802,-0.0026047751,-0.09554394,-0.005083641,-0.015142451,-0.03719657,0.014505561,0.01866963,0.07946696,-0.007343458,0.045491923,-0.00065623794,0.019309187,0.08839718,0.0114609,0.06637911,0.036507796,0.0129850535,0.034280512,-0.015661644,-0.04533942,0.0018887041,-0.039241295,0.05556821,-0.009383235,-0.034749866,-0.0423224,-0.016256869,-0.100872114,-0.07157492,0.094867,0.035492763,-0.04418847,-0.014269051,0.07518319,-0.052811787,0.028342707,0.057552375,-3.7929663e-08,-0.032681644,-0.107575566,-0.050537772,0.0062425765,-0.0068048746,-0.044012785,0.0332364,0.029337086,0.045116454,0.0032096647,0.032197937,0.021820191,-0.046260525,0.0029587527,-0.01963788,0.048360597,0.011518979,0.03633767,0.02932191,0.037748706,-0.05058738,0.018979792,-0.04089219,0.030366037,-0.047411628,-0.106568135,-0.022427043,-0.015159613,0.10787021,-0.04107482,0.062038228,0.0773832,-0.032741465,-0.05708023,0.05914733,0.06469717,-0.07457146,-0.04184079,-0.0012644887,-0.021931913,-0.0046090386,-0.025035953,-0.025128584,-0.042961642,-0.015197273,-0.028788371,0.044953402,0.021701708,-0.015165031,-0.012323107,-0.0043204436,-0.017617047,0.021293472,-0.13752615,-0.098409556,-0.00045121397,0.02738798,-0.055324625,-0.056705933,-0.095268406,-0.04083464,0.009973964,0.21137995,0.050786294 +1.14.14.141,"This microsomal cytochrome P-450 (heme-thiolate) enzyme is rather specific for (+)-marmesin, although it can also accept 5-hydroxymarmesin to a much lesser extent. Furanocoumarins protect plants from fungal invasion and herbivore attack. (+)-Columbianetin, the angular furanocoumarin analogue of the linear furanocoumarin (+)-marmesin, acts as a competitive inhibitor even though it is not a substrate.",384,1.0,-0.06836567,0.002130179,-0.07519016,0.028801844,0.14622979,0.087941945,-0.11094965,0.07473868,0.04479674,0.020790456,0.03213353,0.033237893,-0.13459101,-0.008455554,-0.042087007,0.033694346,-0.0788001,0.08518851,-0.008854532,0.055201005,-0.020133365,0.026787996,-0.017366948,0.08336896,-0.0065228897,-0.07127871,-0.0315174,0.07907985,0.0186536,0.037502203,-0.0032605783,0.03233581,0.06919297,0.0327267,-0.06507803,-0.034970313,-0.034911208,-0.079595245,0.042442456,-0.08119887,0.045208525,-0.03177309,0.0097613325,-0.04243419,-0.08553614,-0.12909693,-0.04518299,0.042188518,0.05289906,-0.017167982,-0.06787625,-0.04663638,-0.12848064,0.0492635,-0.026925977,-0.034616828,-0.038021162,-0.046815902,0.049428966,0.03175933,0.026226623,0.016808346,-0.058495548,0.0155086825,-0.024593385,-0.04356399,-0.07790083,0.043856304,0.051848788,0.055030886,0.016491946,-0.09105423,0.004447364,0.013169245,-0.006522719,0.12742911,-0.12275712,0.0019618473,0.0099887755,-0.050613914,0.012519663,0.044575818,0.049486678,0.08344397,0.039714955,0.0148895085,-0.017203359,0.031655498,0.041564588,-0.017668476,0.08268299,0.023999128,-0.019356549,-0.045007285,-0.09650194,0.032790605,0.06490625,-0.0002559395,-0.07802957,-0.001122135,0.0451892,-0.009774031,-0.014420426,-0.13780433,-0.023932328,0.08365694,-0.05322208,-0.045102607,0.07094917,-0.06678202,-0.032507155,0.012708914,-0.06899,-0.00055377645,-0.022212539,0.024539806,-0.038642596,-0.09943426,0.06381467,0.017932672,-0.030826394,-0.009637179,0.055417173,0.026824497,0.032130376,-0.022940127,-0.0431474,2.5286702e-33,0.033627693,-0.027310241,-0.021301122,-0.012455598,-0.007699988,-0.048130736,-0.053687405,-0.015344946,-0.035797656,-0.010913428,-0.0747858,-0.029683465,-0.0060514896,-0.00024473137,-0.028960831,-0.029308904,-0.0054472783,-0.07387449,0.07383921,0.05979679,-0.0053615095,-0.03158477,-0.036055602,0.031146199,0.0046704076,0.10316884,-0.028774004,0.0707241,0.01667764,0.031293835,0.032261442,-0.01643797,-0.079652704,0.020522552,0.071002655,0.07358956,-0.024617486,-0.036995005,-0.06721706,0.08368926,-0.031232126,-0.009889193,-0.011322227,-0.035089508,0.07811279,-0.008697332,-0.10599028,0.044072907,-0.0036587145,0.021401396,-0.0044678813,-0.029309964,0.059887204,0.067157395,-0.016349843,-0.0053752474,0.044423986,0.028842838,-0.0009422825,0.018895427,0.0072275475,-0.061582264,0.025598366,0.049290657,0.031471685,0.033805408,-0.03256007,-0.033386845,-0.0050749336,0.06030929,0.02392983,0.040120035,0.018815266,0.02000946,0.0712208,-0.01804935,0.067485385,0.10053112,0.00016787738,0.07385545,0.0021596402,-0.040448643,-0.026576657,0.018479269,-0.11050973,0.020511895,-0.011670456,0.005160821,-0.01434027,0.012791508,0.03720825,-0.073856086,-0.0054024197,0.06362665,-0.010728026,-2.577837e-33,0.023002764,-0.06637812,0.08867623,-0.026749656,-0.103373945,0.123176716,-0.00965102,-0.05918062,-0.03460736,-0.03646062,0.13376415,-0.015310648,0.01856171,0.019808155,0.010671159,0.022048494,0.008939019,-0.052648097,0.003485552,0.036891658,-0.05700801,0.02624747,0.0016264336,0.06282602,0.050021414,-0.005239922,-0.0051963846,0.013490803,0.0027703939,-0.0018042364,0.015591308,0.023375211,-0.051346965,-0.043264702,-0.02802001,0.013570105,0.0010829519,0.03921596,-0.014014371,0.02537523,0.05661687,0.014232912,0.024476219,0.0939069,0.01961134,0.020755941,-0.0412938,-0.018033948,-0.048735153,0.021882793,0.043076366,0.05804796,0.0028168005,0.02895857,0.06343404,-0.010882549,0.09332719,-0.028380487,-0.026748843,-0.02450762,-0.07813377,-0.023318058,-0.047637444,0.01583658,0.054419994,0.09566191,-0.07125634,0.06099247,0.015962556,0.0006509727,0.102368034,0.02221726,0.06851811,0.06473034,-0.06420666,-0.006478587,0.08314842,-0.048240993,-0.035330683,-0.009115098,-0.00081697584,-0.06763254,-0.036101542,-0.06728897,-0.06359178,-0.021372136,-0.03163187,0.07845726,0.01840008,0.019452713,-0.03124921,0.074428566,-0.05275274,-0.034484684,0.08446692,-3.6933823e-08,-0.024287099,-0.09456697,-0.030836,-0.038460694,0.0144360615,-0.005175613,-0.010789251,-0.0050724773,-0.019602282,0.060521755,-0.0315459,0.10608898,0.010128929,-0.014519032,-0.04859852,-0.03191568,0.08557851,0.008659149,0.0047913613,0.0013774326,-0.08295376,0.043181583,-0.042298064,-0.071851425,-0.0073147966,-0.10822219,-0.011972047,0.014286676,0.05223956,0.02431587,0.025359347,0.027744308,-0.048201017,0.035751157,-0.015317741,0.06390361,0.001970483,-0.08430272,-0.0040559066,0.002330071,-0.021064693,0.012907185,-0.05493557,-0.06651211,-0.0345508,-0.017779209,0.11520149,0.030995505,0.012067659,0.010832158,-0.022860972,0.021762539,0.028686224,-0.07754914,-0.08815226,-0.021123368,0.1079483,-0.0013601283,-0.04336198,-0.02324788,-0.056666188,-0.092774376,0.11741481,0.048649654 +1.14.14.142,"A membrane-bound cytochrome P-450 (heme-thiolate) protein that is associated with the endoplasmic reticulum [1,2]. This enzyme is specific for sophoraflavanone B as substrate. Along with EC 2.5.1.70 (naringenin 8-dimethylallyltransferase) and EC 2.5.1.71 (leachianone G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone G biosynthetic pathway.",384,1.0,0.01660362,0.010114773,-0.09835723,-0.018249316,0.025347438,0.11644638,-0.058712475,0.09440784,0.03319584,-0.042895082,-0.045186456,-0.029359952,-0.035146635,0.03459928,-0.043335516,-0.020566363,-0.07178162,-0.0011657649,-0.07456426,-0.10522621,0.09208706,0.0059639146,0.080796115,-0.011926167,-0.0022922468,-0.011096217,0.001267237,-0.032492533,-0.05171356,-0.09252534,0.0023181245,0.002177331,-0.024609098,-0.022954332,-0.0013309671,0.13813213,-0.056740806,-0.0036975523,-0.008428054,-0.011757605,0.03688913,-0.03816505,-0.07414782,0.058982223,0.01720829,0.0026182204,-0.012025754,0.022217767,0.01052079,0.027583065,-0.047408625,-0.04510972,-0.03189282,0.02361134,0.04137945,0.08150043,0.015816567,-0.021454347,-0.013339205,0.042299714,-2.4328714e-05,-0.01579603,0.036530945,0.002427161,0.017019255,-0.02974066,0.020816222,-0.094489254,-0.024108777,-0.06841825,-0.03559354,-0.08425659,-0.09187641,0.04450563,-0.08242039,0.10817364,-0.07909269,0.082110666,-0.032384556,0.004054011,0.12977476,-0.0074008806,0.030350586,0.1142228,0.043324057,-0.0502368,-0.020402594,0.016386542,-0.01895144,0.08769604,0.034119934,-0.0130608715,0.011142075,-0.0020168466,-0.08905667,-0.003095588,0.008023697,-0.01840972,-0.020863673,-0.052903987,0.013242305,-0.0067638364,0.025233889,-0.04792628,-0.0111887995,-0.048038952,-0.00872422,0.04868719,0.08774204,-0.08132637,0.028407447,-0.07866612,0.045484148,-0.022760207,0.036127903,0.10698401,0.017757244,0.02623894,-0.018513156,0.011264374,-0.04370266,0.028678678,0.026765224,0.061008487,-0.032337498,0.029985268,-0.15327233,5.2022748e-33,0.06564346,0.012153606,-0.015443368,0.021701561,-0.01427341,-0.009122505,-0.025940606,0.06129597,0.017469056,-0.052765362,-0.0824947,-0.049192432,-0.0068853316,-0.017580872,-0.0006881348,0.00027531083,-0.08611435,0.021213423,0.033656295,-0.07974837,0.00025166318,-0.005500782,-0.042085484,-0.0431821,0.05170181,0.062482916,-0.06356856,-0.009396843,0.052597366,0.0041286997,-0.009117517,-0.09553878,-0.071610235,0.007296176,0.028685514,-0.075644575,-0.012488127,-0.023712697,-0.07187444,0.02383737,-0.070713095,-0.029299676,-0.02416031,-0.055145297,0.05282413,-0.070432685,-0.085427724,0.08463516,0.0316654,0.033339273,0.013927396,-0.0029061756,0.108189605,0.05313634,-0.089718744,0.013310019,0.017604422,0.048790187,0.00032331602,0.09105854,0.1057426,0.13393971,-0.0022246437,0.015938293,0.049186643,0.048745826,-0.025488775,-0.04077839,-0.045433298,0.08763947,-0.0046822587,-0.025423037,0.10588111,0.022520835,0.017466864,-0.0024932483,-0.05970818,0.045112256,0.0413669,-0.02700631,0.036641765,-0.057904087,-0.009112367,-0.018183282,-0.014140988,-0.025956465,0.05089365,-0.047131374,-0.047044117,0.031918388,0.015296267,-0.06660728,0.014120193,0.07120911,-0.0077462513,-4.8666928e-33,0.061865658,-0.07679369,0.03106769,-0.07238063,-0.025476389,0.10131478,0.019869223,-0.019568825,-0.036229555,0.028052522,0.074556455,-0.03772368,0.03491901,-0.008817879,0.015498903,-0.07414203,0.010669913,0.010053793,-0.019397859,0.0010870202,-0.007807081,-0.0016832093,-0.03320532,0.062956855,0.039767716,0.038022578,0.07378966,-0.0072725196,-0.02968117,0.042174738,-0.046445224,0.04806117,-0.0896067,-0.060148448,-0.05090612,0.008650873,-0.01159373,-0.0028404987,-0.00041283047,0.019644009,-0.02819397,0.031350877,0.014013016,0.041011073,0.04585491,0.030844623,-0.09352937,0.0059636645,0.04375808,-0.08385701,0.0017949254,0.03157461,0.010767081,0.031400975,-0.062079024,0.010990037,0.030645508,-0.0021136834,0.00042895897,-0.09557457,-0.019618537,-0.060590032,0.032818247,0.009438357,0.054352906,0.04556608,-0.007541145,0.018554686,-0.004627809,0.012567576,0.026647639,-0.06368873,0.092090294,0.11364659,-0.030539628,0.025847174,0.039007675,-0.049746335,0.09018646,-0.044787604,-0.0027196223,0.023936722,-0.020378131,-0.050493307,0.05033173,-0.11495945,-0.013655148,0.085421294,0.029883726,0.028694293,-0.009055858,0.037319172,-0.09022197,0.030423934,0.038446337,-4.717371e-08,0.045329522,-0.059312437,0.03230807,0.0033924521,0.108568415,0.0015176897,0.051602602,0.029326832,0.031896636,-0.034905672,-0.025147503,0.06045794,-0.02087086,0.026498366,0.039202116,0.024769966,0.015385599,0.06548873,0.0651535,-0.01981372,-0.053943835,-0.07368057,-0.07201153,-0.0414161,0.0721375,-0.10271839,0.01503362,0.03671498,0.05716479,-0.029257352,-0.0024766303,-0.016210822,-0.0029356875,0.025119353,-0.008506104,0.018887553,-0.04977099,-0.0219551,-0.07984369,0.043757934,-0.049313538,-0.047274232,0.024026677,0.017377047,0.03648857,-0.016303094,0.10072722,0.07630541,-0.002260731,0.040757608,-0.011762905,-0.047870114,0.0091667175,-0.067936465,-0.13178061,7.15855e-05,0.010957795,-0.04047272,-0.035386615,-0.032586955,-0.003194962,0.036701255,0.19896789,-0.06998373 +1.14.14.143,"A cytochrome P-450 (heme-thiolate) protein. The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan [1]. This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalysed by EC 1.14.14.99, (S)-limonene 3-monooxygenase [1].",384,1.0,-0.08294673,-0.012445037,-0.059204012,0.0038820454,0.09147771,0.047983564,-0.052010924,0.13633288,-0.0010529784,-0.058821775,0.042156614,-0.01546369,-0.023676442,-0.0064306967,0.010726737,-0.036731735,-0.037504327,0.026090963,0.0019009116,-0.07321934,0.027578738,-0.007926414,0.016107969,-0.009976936,-0.017160885,0.046960566,0.034330793,0.013480912,-0.023321308,-0.027568527,0.0070031984,0.012456945,0.0019324808,0.0032026242,-0.051257562,0.060439244,-0.027007053,-0.10237551,0.076632254,-0.04308863,0.094541445,-0.0011282731,-0.052089423,-0.017442822,-0.01108761,-0.07520275,-0.014763601,-0.005944162,0.005900602,-0.070217535,-0.0046734274,-0.001707598,-0.015698127,0.042578917,-0.039185584,-0.0057099843,0.0500995,-0.03664878,-0.026450105,0.019873347,-0.054292683,0.06403541,-0.066172116,0.029222405,0.0043615755,-0.07881996,-0.030554565,-0.022994487,0.009132666,-0.060428325,-0.02732195,-0.09596688,-0.07877891,-0.041602876,-0.08653519,0.07934359,0.003422466,0.029697916,-0.06559943,-0.02177898,0.050865382,0.062276747,0.009856683,0.10385485,0.034667417,-0.020127092,-0.043727014,0.049047552,-0.019594032,0.038183454,-0.008362559,0.05269006,-0.029976802,0.025318457,-0.12950748,0.062015396,0.07930878,-0.013333468,-0.028881337,0.010352939,0.020403378,0.102242485,-0.03796817,-0.12771034,-0.051872738,-0.0125702815,0.0029699972,0.060787644,0.046671562,-0.067828074,0.01945505,-0.057599075,-0.022823026,-0.03244867,0.010136026,0.10060455,-0.0003740666,-0.02122846,0.0065656253,-0.015098429,-0.030966172,-0.004884055,0.0011566862,-0.022315862,-0.028040644,0.0028960248,-0.040241394,1.7499878e-33,0.033597816,-0.028883403,-0.023733597,0.0369718,-0.048833977,0.042847905,-0.064405374,0.054965083,-0.0043449732,-0.029093748,-0.06063933,-0.07513877,-0.04087933,-0.00802291,-0.07200234,-0.042353515,-0.03636512,0.06184059,0.09035556,-0.0094046565,-0.058330208,-4.589044e-06,-0.036946043,-0.037437364,0.027068187,0.104012854,0.01188788,-0.05088693,0.03758898,0.008039508,-0.077176884,-0.016042946,-0.043147095,-0.03727169,-0.003312233,-0.014981731,-0.0063826516,-0.027363816,-0.07197135,0.07680927,-0.019946031,-0.04113473,-0.010029898,-0.08219681,0.02196295,0.028687814,-0.12512381,0.05055378,0.010583353,0.027257133,0.0423325,-0.03570241,0.13457966,0.06626119,-0.060913004,0.009426785,-0.008877161,-0.025453573,0.03810411,0.03612855,0.11299775,0.056441404,-0.05178343,0.048685182,0.049605627,0.08225734,-0.0889772,-0.037949458,0.004844513,0.16077429,-0.06162237,0.010503233,0.06870655,-0.013219523,0.1325853,-0.013371984,0.0015055906,0.10340317,0.10323608,0.052253433,0.00065778627,0.0227075,0.009570787,-0.014845106,0.010267889,0.016635425,0.015945561,-0.01461452,-0.012949043,0.03978105,0.0591562,-0.06716634,0.021342283,0.019421821,-0.05471934,-2.4469731e-33,0.03603872,-0.05295885,-0.020863926,-0.097506866,-0.043559622,0.062668286,-0.029871793,-0.018119803,-0.052433245,0.022857951,0.07378446,-0.06100625,0.006300581,-0.049017724,0.003999442,0.015438192,-0.0040046433,0.053558335,-0.041935254,0.060055606,0.010519198,0.004927121,0.028734557,0.06406746,0.024812644,-0.0009935359,0.034533154,0.0005533534,0.07046189,0.0036132913,0.005626008,0.039641306,-0.05374761,-0.005996925,-0.03959133,0.10787403,-0.00028280914,0.045267142,0.009188486,0.071122326,-0.06117847,0.024513029,0.005361185,0.067383744,0.04752838,0.01749296,-0.10333964,-0.057818122,-0.0052889055,0.010506078,0.06930777,0.0150365075,-0.024681352,0.030633934,-0.020222249,-0.008297773,0.016581263,-0.02637497,0.033348788,-0.09588245,-0.055900868,-0.042742085,-0.03985466,0.06388188,0.013327958,0.0037062904,-0.044977885,0.035219867,0.03724928,0.002889792,0.0660924,0.011432268,0.10734629,0.049282502,0.03211618,0.03012486,0.064605266,-0.044392735,0.03764987,-0.010658437,-0.0036446492,0.0017855013,-0.054928724,-0.08045639,-0.064297676,-0.118824966,-0.017341953,0.06998574,0.046984933,-0.027984582,-0.012089542,0.081151105,-0.062116753,0.08398702,0.12640254,-4.1470244e-08,-0.020190151,-0.11285228,-0.0070475093,0.10117338,-0.014478481,0.060099903,0.0146458475,-0.04245798,0.041787785,-0.019926092,0.020066407,0.050908912,-0.008484392,0.008469869,-0.004408823,0.02829317,0.032542065,0.019933563,0.050405975,0.047170945,-0.05776784,-0.02547759,-0.009889453,-0.017609067,0.035545588,-0.13929473,-0.043156043,0.01413574,0.03573261,-0.036892474,0.029996071,0.056813117,-0.056740157,0.032719415,0.047659308,-0.019849842,-0.04381808,-0.031181073,-0.029088957,-0.010794989,-0.053691633,-0.056418367,-0.09264135,-0.010783124,-0.004636808,-0.01443284,0.008781202,0.06969577,-0.011405013,0.012013993,-0.011441117,0.003944812,0.04615069,-0.10427443,-0.07311903,-0.0010318212,0.053054053,-0.0037967195,-0.07383518,-0.11174631,0.007585739,0.03070217,0.16603073,0.034903746 +1.14.14.144,A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). Activity is induced by wounding of the plant tissue [2].,384,1.0,-0.06572068,-0.01694222,-0.0464969,-0.008040316,0.046424635,0.06963217,-0.028540384,0.05133606,0.023390636,0.06683533,-0.00991164,0.0038111645,-0.0684932,-0.036835946,-0.03516341,0.079293065,-0.07713933,-0.013703462,-0.055090062,-0.058907054,0.058291383,0.046478532,0.005571223,0.054740816,-0.013578554,-0.09974211,0.036061294,0.022181079,0.026025042,-0.047938865,-0.028174745,0.008273094,0.10407325,0.03625568,-0.051481847,0.07980637,-0.008866231,-0.0995924,0.06374589,0.0026484726,0.09088114,0.021425812,-0.089222856,0.0206602,-0.030505612,-0.018923003,0.039572775,-0.04603139,0.029228546,-0.025520843,0.001799062,-0.0055359104,-0.03520234,-0.01120894,-0.034830503,0.012368897,0.03384028,-0.005325611,0.060954034,0.023089569,0.032993257,0.022930954,-0.01975468,0.0051546823,-0.045257214,-0.033136137,-0.06672834,0.01696197,-0.015530828,-0.09311828,0.008214299,-0.11199055,-0.022547321,-0.05303225,-0.08038051,0.07306711,-0.05778225,0.027018461,-0.028942661,-0.0030975372,-0.009272266,-0.036569443,0.007735577,0.1200004,-0.007753387,0.009074854,0.009861922,0.07693502,-0.06834347,-0.06535849,0.03167585,-0.0358979,0.010374374,0.012372192,-0.10801892,0.07013149,0.072558396,-0.12740766,-0.042650804,-0.021694666,-0.021633586,0.09777669,0.026995618,-0.095921874,-0.067694224,-0.034867264,0.0008447726,0.08914546,0.074008554,-0.015404615,-0.008301455,-0.04027596,-0.004838853,0.03590071,-0.037818763,0.0747881,-0.023846475,-0.10294364,-0.03168201,-0.035321187,0.019843142,-0.00583749,0.07284338,0.05129609,-0.052258264,0.004788389,-0.042462755,2.076415e-33,0.093514875,0.05810523,-0.06043458,-0.016849853,0.0062917783,0.0009942987,-0.11462253,-5.486439e-05,-0.043106228,0.023396181,-0.053584605,-0.071113534,0.07034556,-0.041243806,-0.004751015,0.03257151,-0.0659182,-0.01145469,0.08956529,0.03857937,-0.09711471,-0.0075388737,-0.08235202,0.0066576116,-0.018504884,0.07184198,-0.03899824,-0.025935814,0.03030565,-0.027392888,0.02070761,-0.037284262,-0.06840536,-0.054371256,0.020775108,-0.04969758,-0.012995396,-0.029563643,-0.080324076,0.032524034,-0.026289402,0.0049848366,0.07949128,-0.08456201,0.083238624,-0.039087117,-0.089714766,0.016333403,0.0056178453,0.072618276,0.052309424,0.005590439,0.13626674,0.030324025,-0.0621483,0.011125956,-0.025272522,0.018169,0.06001282,0.081595995,0.11607035,-0.028520903,-0.04316416,0.059834708,-0.040275127,0.045239866,-0.096182145,-0.00011635072,-0.029658152,0.099925555,-0.031085353,-0.061953828,0.036415707,-0.067501515,-0.0348087,0.04257775,0.046004154,0.09083094,0.004836188,0.0674697,-0.002545849,0.022002835,0.012727657,0.0138524305,0.05561371,-0.015883677,-0.007039864,0.004978275,0.0252402,0.013649249,0.017056597,-0.02013151,-0.05388109,0.01956376,0.0064988104,-1.9832812e-33,0.07341582,-0.062680684,0.0072205295,-0.118336566,0.006085945,0.0466929,-0.0028615836,-0.04012287,-0.01815284,-0.024522007,0.08272937,0.014912504,-0.00082239846,0.018149847,3.9909806e-05,-0.023863535,-0.014958619,0.093651004,-0.038304057,0.03046219,0.018912748,0.06621251,0.012402039,-0.07371793,0.031439338,0.013725608,0.011376649,0.012581884,0.014759363,0.03087253,0.025737757,0.054123793,-0.132615,-0.008358844,-0.024309725,0.036618333,0.017719679,0.019129572,0.012881008,-0.0058998927,-0.044224698,0.04303172,0.025839541,0.060433608,0.09042324,0.04311621,-0.07077066,-0.0060922625,-0.03524128,0.02759591,0.021189835,-0.018978547,0.008175871,0.0070833443,0.030091798,-0.028920176,0.020770023,0.0028209523,-0.0469925,-0.0997836,-0.04237598,-0.0071940515,0.059361026,0.006024477,0.024274275,0.094026916,-0.03942056,0.09972928,-0.008547499,0.0047693076,0.05589129,0.042508233,0.023003206,0.1001382,-0.012709395,0.07322929,-0.0008706773,-0.084270254,-0.03367738,0.014911586,-0.0097345505,0.05495013,-0.09726352,-0.04196968,-0.045202624,-0.054448638,-0.031551704,0.076066956,0.029038679,-0.078557335,-0.03283511,0.021871472,0.01725514,0.05508932,0.022308188,-3.517651e-08,-0.07675599,-0.00054022286,-0.034346912,-0.00027467203,0.050496645,-0.009395823,-0.04592432,-0.0035592848,0.003915585,-0.054023538,-0.028873587,0.045043133,-0.058278363,0.058284074,0.0040016305,0.031352375,0.033184122,0.003944925,0.03727859,0.022384645,-0.039176594,0.0018998338,0.01666939,0.083652444,-0.016547613,-0.1678535,0.015418589,-0.020838877,0.05991792,0.015803372,0.076377444,0.09750358,0.017252507,0.03442672,0.043261122,-0.019759376,-0.010501093,0.04713449,-0.06208359,-0.008352376,0.008900494,-0.081991784,-0.02647394,-0.072881676,-0.033155523,-0.011171471,0.036503814,0.08334508,0.034975793,0.039868068,0.02183416,-0.034187682,0.0536578,-0.02257441,-0.055285357,-0.04098264,0.0310098,-0.06360153,0.08442358,-0.06628904,0.0015771376,0.00709951,0.1655938,-0.04549872 +1.14.14.145,"A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine) [1], and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine) [3]. The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene.",384,1.0,-0.034353897,-0.060360704,-0.0545563,0.00882698,0.018620718,0.012508169,-0.052656386,4.131806e-06,0.06343717,0.05962395,0.009657996,0.034110613,-0.06555181,-0.029335802,-0.038772587,0.08975602,-0.099086195,-0.024402488,-0.027769772,-0.024479244,0.08755451,0.0193308,0.011515349,0.06199232,0.023587007,-0.08453796,0.036584575,0.0092039015,-0.01872552,-0.07575095,0.02853414,-0.00608768,0.061415575,0.017429443,-0.048535887,0.054886147,-0.037409004,-0.0861481,0.08097227,0.033244666,0.06533133,0.041111905,-0.07098496,-0.0026193266,-0.059048492,-0.020221075,-0.0072722505,-0.0133917425,0.024440594,0.019797564,0.01126074,-0.02617837,-0.029707475,-0.0126162125,0.006650121,-0.038148563,0.049411826,-0.023906419,0.032069217,0.05912488,0.024209429,0.03834112,-0.03238017,-0.015673177,-0.08038301,-0.026752595,-0.03926186,-0.0041924296,-0.022722233,-0.11434247,-0.034331027,-0.12624376,-0.044148557,-0.045491006,-0.049661968,0.031447243,-0.04545251,0.026416168,-0.036758658,-0.03855688,-0.009722073,-0.02410133,0.026387691,0.13345493,0.027532736,-0.0019963149,0.0014450286,0.042241916,-0.03930597,-0.030653074,0.024870524,-0.01129807,-0.0017859647,-0.025043927,-0.031358756,0.09031797,0.092522934,-0.073355086,-0.0784522,-0.015031385,-0.030677937,0.062113456,-0.010643541,-0.11330149,-0.07173041,-0.022597617,0.020226214,0.040738646,0.06821303,-0.0470233,0.015833952,-0.017533392,0.034708038,0.05320379,-0.05862165,0.05861532,-0.0024288131,-0.094016016,-0.03855346,-0.023584666,-0.0041104383,0.0068325615,0.11631663,0.05645958,-0.07678551,0.0066574467,-0.011814985,4.916168e-33,0.0625946,0.0410937,-0.08782707,0.011531691,0.01032721,-0.016508179,-0.110149845,0.031897336,-0.03286853,0.010188645,-0.084778875,-0.060883258,0.030007135,-0.037509184,0.059453666,0.058018245,-0.019076463,-0.018283572,0.09142242,0.027489087,-0.06720254,-0.00076785847,-0.09203112,-0.005698652,-0.0052088303,0.09026874,-0.026767302,-0.011349332,0.020847388,-0.022637662,0.021855233,-0.045441803,-0.07222393,-0.050602794,0.0037076536,-0.030905971,-0.027071003,-0.025252352,-0.10255578,0.0311073,0.0016230223,0.01314819,0.042091306,-0.052959252,0.054141417,-0.0030783524,-0.055097602,0.02345703,0.02313504,0.06642455,0.04882085,0.0060007623,0.11333904,0.010206657,-0.113411464,0.043810237,-0.030370947,-0.01494512,0.08617152,0.07657144,0.0821508,-4.0715615e-05,-0.03486667,-0.0066460785,-0.036110714,0.025591388,-0.08295643,0.023740638,-0.04894025,0.0711161,-0.02935625,-0.06791627,0.04895373,-0.06081993,-0.034121618,0.05620474,0.04099748,0.083222754,0.041332275,0.043424685,-0.018023154,0.017960377,0.033926815,-0.03446389,0.04329748,-0.038030468,-0.0027260932,0.015446911,0.020718435,0.039542556,0.011367519,-0.009342971,-0.036199305,0.0004773979,0.03139832,-5.255645e-33,0.07121412,-0.10015812,0.027213756,-0.13192524,-0.0031537674,0.045106873,-0.030509673,-0.040862925,0.0016788803,-0.040582657,0.053796776,0.0034746965,-0.007003012,-0.007626475,0.03186346,0.001853485,-0.03380977,0.11155067,-0.04757149,-0.022939527,0.03696173,0.09725903,0.0069651087,-0.054357465,0.018001655,-0.0069745034,0.036020804,0.0076133856,0.028551886,0.065099895,0.041128762,0.046361312,-0.06653228,-0.001636821,-0.027596068,0.08437497,-0.03732132,0.012234618,-0.030573573,0.0346816,-0.037076548,0.026262352,-0.0043405965,0.02099926,0.11598389,0.02019998,-0.13335118,-0.025523784,0.0031086726,0.030042471,0.0771007,0.0029687956,0.010176256,-0.0022006314,0.042137776,0.0020604047,-0.010930674,-0.0046958365,-0.0041730655,-0.10995363,-0.04273074,-0.012679234,0.055917274,0.0022783477,6.738022e-06,0.062112257,-0.06127621,0.08002694,0.005607224,-0.00552273,0.051962785,0.04179134,0.010432671,0.07985833,-0.010559959,0.066681966,-0.009493454,-0.08166111,-0.04650289,-0.0035856508,-0.0041509857,0.048453767,-0.05643372,-0.02747374,-0.07134401,-0.06385109,0.023120118,0.09301217,0.024350679,-0.066887915,-0.0015918297,0.030800845,0.016335122,0.066762194,0.02074925,-4.670897e-08,-0.08062715,0.020538386,-0.0002098118,0.035596807,0.023414016,-0.011248455,-0.0211087,-0.007880355,-0.0100440765,-0.07809286,-0.020291075,0.08602367,-0.07450628,0.059558287,0.022829028,0.035010934,-0.001493935,-0.015922893,0.04830106,0.093650125,-0.0108117685,-0.0069853566,0.012200614,0.08683864,-0.023276925,-0.17788821,0.029474843,-0.0051353113,0.058539774,0.012624257,0.074451186,0.09565485,-0.0051331306,0.024756975,0.00408535,-0.038752764,-0.0137199415,0.035967413,-0.054493822,0.03434689,0.009994105,-0.13074689,-0.022101466,-0.05525926,-0.022026692,-0.022590302,0.02669636,0.06742784,0.035935096,0.06810044,0.03821751,-0.0077678817,0.040338986,-0.0021663741,-0.056485817,-0.04244084,-0.0023967081,-0.05207362,0.06739743,-0.12203214,0.029092079,-0.0021576004,0.20357636,-0.014215132 +1.14.14.146,A cytochrome P-450 (heme-thiolate) protein isolated from the plant Croton sublyratus.,384,1.0,-0.06293037,0.02835137,0.0030928785,-0.030035896,0.057430796,0.11391439,-0.011242369,0.082144715,-0.029199224,0.026492856,0.03910887,-0.043169636,-0.04638939,-0.013061948,-0.04232362,0.025033595,-0.02109251,-0.07130667,0.016323363,-0.04496017,-0.002879185,0.057194084,-0.042233303,0.060520887,0.046288926,0.013977103,-0.06641998,0.092172645,0.011419912,0.010886233,-0.04914624,-0.0124632185,0.031493623,0.0236049,0.037573963,0.086748965,-0.03658639,-0.11590412,0.040671494,0.0051008156,0.04572721,0.035485152,-0.09394132,0.027970303,-0.04493731,-0.018771822,0.013462642,0.01055824,0.038419444,-0.022689074,0.0025097367,-0.037119187,-0.05053184,0.062360518,-0.015965702,0.05894331,0.035892345,0.08073405,0.02462608,0.029367715,-0.05850743,0.029870072,0.010502805,-0.015413943,0.00017455027,-0.04842109,-0.10434641,0.053379033,0.068096645,-0.0361904,0.02039855,-0.056201335,-0.019739382,0.025163155,-0.084465995,0.030109044,-0.06737945,-0.0057314876,-0.034908906,0.009244466,0.012838762,0.023655478,0.022459475,0.076124236,0.035222568,0.0071408027,-0.019274736,0.05045547,-0.062871836,-0.08747136,0.020502334,0.0025909254,0.014656534,-0.044676434,-0.070351966,0.080848284,0.042522214,-0.07349323,0.0017093094,-0.02728185,0.06469268,0.058550544,0.020667162,-0.088544495,-0.053399723,0.040776882,-0.037088092,0.060300387,0.018382467,-0.09714502,-0.058277674,0.016280103,0.0018750983,-0.05444013,0.022457289,0.0358105,-0.054223347,-0.0050889677,0.018518286,-0.05559765,-0.018934766,-0.018683301,0.024414418,-0.006659343,-0.015868392,0.022792717,-0.10887935,6.887801e-34,0.08762432,0.05822373,-0.015098056,-0.00042219623,-0.0549065,-0.006737051,-0.03536057,0.07967751,-0.0855275,-0.024362417,-0.087161504,-0.088325396,0.011555334,-0.06645044,-0.019870656,-0.0016445885,-0.07666728,0.024790399,0.07027627,0.000422825,-0.06582429,0.016403044,-0.04336749,-0.020545652,-0.0480058,0.038384184,-0.008327226,-0.0238714,0.03964695,-0.013535044,-0.01191956,0.002465953,-0.027379839,-0.030421421,0.07439183,-0.042257722,-0.0027662772,-0.0108533725,-0.089930214,0.070630275,0.03439302,0.026000781,0.056547917,-0.12349776,0.076841764,-0.017893426,-0.13849793,-0.030696629,0.012530504,0.020583328,0.054648146,-0.031599782,0.1258899,0.064804964,-0.07952304,0.007593244,0.018233117,0.01343475,0.02571921,0.054816954,0.059730165,0.024889905,-0.03901923,0.017189974,0.062046885,0.064107396,-0.088710815,-0.028181221,-0.021058884,0.08961205,-0.031109096,-0.031272527,0.029099759,-0.0848246,0.06767472,-0.05531436,-0.009696265,0.08679275,-0.013421563,0.070046745,0.024068754,-0.02757024,0.0035945692,-0.031178663,-0.003160297,-0.047389764,0.06196275,0.0103027355,0.003445282,0.0826334,0.092622556,-0.07265393,0.026850754,0.0072538326,-0.08189038,-2.0548672e-35,0.04105001,-0.03784871,0.03481643,-0.058063276,-0.06665454,0.11378187,0.013744697,-0.0006611003,-0.018793179,0.032492507,0.11667177,0.0075148507,-0.009843903,-0.022203099,-0.01671759,0.04136779,-0.04320626,0.049475066,0.0053143892,0.07606745,-0.031265557,-0.038351193,0.030521784,-0.00077174004,0.043153584,0.043115746,0.038546164,0.012799162,0.069007054,-0.059923768,-0.0011803977,0.02289713,-0.10203816,-0.039131608,-0.057851072,0.0039640632,-0.06441472,-0.031203348,0.046145532,0.04258697,0.018587291,0.11545843,0.054191917,0.07629951,0.05305896,0.054224443,-0.0930255,-0.02458853,-0.08568479,0.025253499,0.008545204,-0.027614648,-0.020394458,0.016653335,0.005030132,-0.039027475,-0.050171424,0.10660929,-0.024758628,-0.00012207808,0.021762637,-0.02524,-0.068000674,0.100889765,0.047382038,0.08467249,-0.031233108,0.07291592,-0.0533479,0.03502279,0.01358046,-0.009994055,0.08266591,0.05518891,0.045939572,0.00934477,-0.036903948,0.02014776,-0.0011705494,0.049687687,0.03367405,0.009244442,-0.03719911,-0.060525805,-0.0054330523,-0.06567061,-0.08652346,0.089744486,0.057607353,-0.040753473,-0.02398106,0.015335651,0.0003666101,0.017741252,0.17206044,-2.345027e-08,0.024504337,-0.09150711,0.005794355,-0.04036767,0.027236676,-0.027893165,0.014357285,-0.0070025125,0.019877465,0.024613459,0.0012949506,-0.050343454,-0.02926583,-0.02898608,-0.042117476,0.04139469,0.022532653,0.016684264,0.051434148,0.08668807,-0.040044658,0.032378316,-0.022668255,0.06370953,0.027418124,-0.09299978,0.043738432,0.032280914,0.03771085,0.016445685,0.02993432,0.050156035,-0.03348145,-0.0028797095,-0.0060963696,0.01603695,-0.0424073,-0.009498829,-0.05198188,-0.046058476,-0.008105247,-0.053911984,-0.074023895,-0.06153021,0.027223201,-0.017313179,0.058152623,0.040000275,-0.017091282,-0.024271416,-0.010934186,-0.009994629,0.057754464,-0.13531926,-0.11295512,-0.03381541,0.05945548,-0.047376145,-0.053139895,-0.10833219,-0.041716214,0.039378524,0.11617524,0.034690548 +1.14.14.147,"A cytochrome P-450 (heme-thiolate) protein involved in brassinosteroid biosynthesis in plants. The enzyme has a relaxed substrate specificity, and C-23 hydroxylation can occur at different stages in the pathway. In Arabidopsis thaliana two isozymes, encoded by the CYP90C1 and CYP90D1 genes, have redundant activities.",384,0.99999994,-0.17058711,0.024051711,-0.009715981,-0.04342096,0.04196457,0.12837566,-0.07735099,0.101051174,-0.022985429,-0.04040117,0.05868742,-0.036005747,-0.019156465,-0.090705544,-0.03608853,0.011059505,-0.070180364,0.06594264,-0.026071489,-0.158,0.011140336,0.046730753,0.0108322445,-0.011979251,0.037869066,0.01139582,-0.021082792,0.07960769,-0.03424422,-0.03875855,-0.049172793,0.04544852,0.007683469,0.027301814,-0.028608736,0.09133595,-0.036849443,-0.09534257,0.0648486,-0.01664878,0.09571927,-0.014550513,-0.08048726,0.05296135,-0.071676455,-0.008732633,0.00020845544,0.019024998,-0.04381294,-0.055128768,0.011513112,0.018026056,0.0034346438,0.030612048,-0.009737517,-0.024605714,0.08682115,0.053188723,0.013678342,-0.008567678,-0.021726288,-0.002062844,-0.034429304,-0.008640463,-0.0086972695,-0.009681572,-0.039338477,-0.013510912,-0.0023639458,-0.041004863,0.01486586,-0.052707173,-0.11919864,0.02790962,-0.09242483,0.14291494,-0.0129466895,0.016603723,-0.07468617,0.0035632262,0.018349055,0.010737717,0.010145996,0.04671395,0.020311614,-0.03638648,-0.038717937,0.05338444,-0.05335548,0.0208471,0.018127501,0.03966658,0.010063502,-0.018232869,-0.05851139,0.10584925,0.05808924,-0.07894489,-0.035163205,-0.031447746,0.056718525,0.06551352,0.009693312,-0.05484041,0.011461005,0.018325355,-0.018043749,-0.014180709,-0.02307901,-0.07356777,-0.020963315,-0.019543303,-0.03126059,-0.011649937,-0.031233795,0.015892701,-0.041707948,0.0049539846,0.0173241,-0.0380364,-0.047974378,-0.06818993,-0.064534955,-0.0027153115,-0.060166817,-0.038319472,-0.13211876,3.8331684e-33,0.04741899,0.019375043,-0.052418076,-0.03427112,-0.022800768,-0.026852101,-0.06250875,0.048716906,-0.046647314,-0.03326962,-0.04668766,-0.116389126,-0.023556218,-0.068318054,-0.068352856,-0.0011914611,-0.059927046,0.046398435,0.056608986,0.025187414,-0.064603806,-0.0070502707,-0.089617,-0.058907893,-0.0066557922,0.063299626,0.01839303,-0.0610616,0.008685834,-0.02570335,-0.07493754,-0.009768947,-0.01779364,-0.0015494749,0.047658622,-0.07112721,0.01966491,-0.045436677,-0.03815407,0.012204433,-0.07587748,0.022005264,0.024755402,-0.032733083,0.09560215,0.017976908,-0.085056625,-0.0033870032,0.025058102,0.051917315,0.087882124,0.019472659,0.12734552,0.05343676,0.013549427,0.013601751,-0.0023534761,0.024318121,-0.044122204,0.058109887,0.08279619,0.04838956,-0.0053865365,0.02464947,0.057885617,0.05190683,-0.10904478,-0.04842893,0.016484795,0.14333513,-0.015153821,-0.06615994,0.07171815,-0.023912368,0.065011635,0.026139267,-0.0012607251,0.055419534,0.03611485,0.033179104,0.027275572,-0.011742926,-0.0260757,-0.004465858,-0.042180754,-0.0094176205,-0.0060747513,-0.003344323,-0.03692704,0.03860843,0.14422569,-0.043525025,-0.008090999,0.04052421,-0.02100076,-4.223045e-33,0.04483554,0.020718448,-0.000842978,-0.097696066,-0.010981836,0.03057974,-0.04521601,-0.050771013,-0.028614903,0.03549283,0.07211075,-0.014938698,-0.01901377,-0.047250602,-0.021785602,-0.02389147,0.05037393,0.095995195,-0.08124634,0.09348011,-0.044294722,0.011606387,0.03308599,0.029606028,-0.009231685,-0.012963378,-0.023584979,0.08299274,0.02508735,-0.01520827,0.0011882249,0.06855801,-0.059352644,-0.03748504,-0.0054597193,0.0055274568,0.020408394,0.050716598,0.0830116,0.049359065,-0.015478524,0.03981245,-0.0044814753,0.09024647,0.034136456,0.037477814,-0.022239443,-0.031774428,-0.07518417,0.009032608,0.0011378697,0.093963355,-0.025732165,0.06550353,-0.0034446847,0.011286309,0.024833389,0.0075243455,0.024018116,-0.022142386,0.035100155,-0.021579012,-0.0073814993,0.08941554,-0.0068056774,0.06312872,-0.030708574,0.050697144,-0.00370349,0.09396839,0.02683686,0.024102915,0.056894913,0.058370043,0.016972778,-0.0061357417,0.014436414,-0.013139103,-0.04253789,0.022955768,0.020025153,0.0350845,-0.072704785,-0.09860672,-0.015962377,-0.084670424,-0.040898502,0.12473803,0.07034247,0.004600716,-0.006437001,0.03793386,-0.062276796,0.07505251,0.05191397,-3.6379724e-08,-0.023978135,-0.057750992,0.01179452,-0.02739156,-0.015577054,-0.003997982,-0.0025392415,0.030148327,0.06665444,-0.02280468,-0.012095675,0.025955327,-0.029852621,-0.01391708,0.08113239,0.010168187,0.037135508,0.011137826,0.04392875,0.07886238,-0.030431863,0.019154964,-0.06803084,0.011103424,-0.02383951,-0.062021088,0.03486088,0.03995508,0.086720325,0.03851064,0.0655143,0.039314162,-0.047553346,-0.032168694,0.0058591785,-0.00993146,-0.0066213994,-0.034808032,0.022058846,-0.048687417,-0.05401433,-0.003975553,-0.115364835,0.032186482,0.059216976,-0.008074338,0.07534761,0.036632027,0.03157135,-0.008422216,-0.04445963,-0.004312094,0.01994427,-0.13068345,-0.044567157,0.0030996862,0.068925224,0.019975526,-0.053895827,-0.041009307,-0.080135174,-0.010446708,0.15769012,-0.042754322 +1.14.14.148,This cytochrome P-450 (heme-thiolate) enzyme from wild parsnip is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'.,384,1.0,-0.09571972,-0.027062679,-0.074054405,-0.0020857563,0.054767452,0.03732314,-0.08801591,0.069508225,0.004395359,0.04067797,-0.022547344,-0.018404445,-0.12774074,-0.011539737,-0.058259975,0.04496863,-0.08053572,0.004721751,0.018279659,0.059917245,-0.054297622,-0.03528759,-0.0231068,0.09132603,0.014434427,0.0420751,0.0436202,0.0595383,-0.008900994,0.00062700483,-0.020069484,-0.024204416,0.03644667,0.026278498,-0.014839526,0.032570817,-0.06059173,-0.049149916,0.0052969544,-0.06926343,0.030178856,-0.017676301,-0.096685454,-0.023209881,-0.024706094,-0.061769117,-0.036845095,0.06540174,0.012914655,-0.018780807,-0.0017537568,0.022195207,-0.08608314,-0.0061764265,-0.0669987,-0.014829567,-0.005999043,-0.051360458,0.0031208647,0.026991922,0.02050999,0.04269536,-0.100591004,0.025180755,0.033206042,-0.05378856,-0.012183525,-0.006036283,0.012183476,0.014253124,-0.044823833,-0.09278696,-0.008519669,-0.041600876,-0.050757583,0.11492333,0.013573393,0.004265277,0.031853057,-0.04289157,0.07679707,0.0360628,0.06679068,0.143043,0.022943608,-0.024928654,0.010476463,-0.00787735,-0.024462318,-0.00067235634,0.020504616,0.017608123,-0.0011900669,-0.04598636,-0.061808366,0.1035385,0.022294037,0.008145364,0.02803933,-0.019678133,0.026565796,0.006046181,0.036237102,-0.10728007,-0.048117504,0.04328262,-0.042727277,0.04106822,0.12889135,-0.05857643,-0.056591734,0.015100315,-0.1036656,-0.0033494772,0.028058318,0.1046936,-0.03241244,-0.111305825,-0.002164068,0.041129142,-0.051886316,-0.004512471,0.011572161,0.034259785,-0.029822478,-0.03597685,-0.029174164,3.3826733e-34,0.06846542,0.012530428,-0.019622229,-0.021677084,-0.024375606,-0.007887278,-0.0703538,-0.003265809,-0.05724903,0.015171683,-0.036174603,-0.10691863,0.049755998,-0.050445493,-0.05594453,-0.0026776076,-0.04226495,0.008620717,0.015864622,-0.002174244,-0.020162774,-0.020349339,-0.036888346,-0.03681019,0.00026498173,0.15797016,-0.100865245,0.054351047,0.049043253,0.010354158,0.054696146,-0.05192539,-0.05229694,-0.0073083965,0.07537915,0.027868534,-0.004628156,-0.043154355,-0.044795405,0.102479175,-0.006880216,-0.070384525,-0.049240578,-0.035599373,0.05374526,-0.013887592,-0.1509621,-0.0006094085,-0.04354226,0.0012384617,0.019346869,-0.06029835,0.094297275,0.03334714,0.019598182,-0.0074916086,0.013430333,-0.024527423,0.054956365,0.020484999,0.103660785,-0.0024715732,-0.027891919,0.06075236,0.05226501,0.02106298,-0.006906019,0.011389574,0.013451727,0.09466476,-0.04301221,0.042004596,0.04968889,-0.047029596,0.084511384,-0.013791051,0.06280856,0.12764888,0.036752522,0.06019722,-0.02619007,-0.04905974,0.034835078,0.014284467,-0.036883682,0.000222766,-0.00052821974,-0.040737294,-0.05611444,0.062307443,0.04106187,-0.09281821,-0.0017144037,-0.013165276,-0.033415947,-2.2295544e-33,0.051986795,-0.042320706,-0.018766597,-0.079742834,-0.078520864,0.12764466,-0.011410507,-0.051377676,-0.050065923,0.043605033,0.12022326,-0.032748908,-0.002976874,0.000840753,-0.0028980458,0.027857479,0.018010912,0.010215477,-0.02919639,0.045413133,0.0068354486,-0.012569406,0.055565972,0.039271824,0.02001544,-0.023846572,0.0331779,-0.037889395,0.02262754,0.02773743,-0.012604986,0.036432426,-0.036366016,-0.052469686,0.0052831266,0.045122292,-0.01655577,0.047745794,-0.03528347,-0.03169906,0.007205288,0.019989133,0.00503832,0.07309786,0.00030729806,0.035439577,-0.082132794,-0.0374888,-0.062358044,-0.03080796,0.07886195,0.044396803,0.008897224,0.06827558,-0.018016271,0.029172357,0.07827264,-0.051961098,0.010109363,-0.0039636027,-0.08330962,-0.03515468,-0.034909848,0.014521556,0.097346224,0.07169895,-0.048714817,0.09237235,0.011243895,-0.046335205,0.017816395,0.013633555,0.0522806,0.05532352,-0.055486497,0.0141008105,0.091198765,-0.038631354,0.07210079,-0.028274182,0.070697255,-0.018600686,-0.05973892,-0.06716851,-0.017978244,-0.10750375,-0.01291602,0.12541582,-0.04041287,-0.037988998,0.012940481,0.062359005,-0.023630692,0.017103286,0.09845578,-3.0683722e-08,0.005697054,-0.059377912,-0.010592825,0.017103745,0.07854858,0.081080526,-0.026062634,0.0039832764,0.0008841434,-0.009468637,0.006927196,0.07843154,0.012018078,-0.029438037,0.040166587,-0.022660848,0.033232573,-0.008230518,0.019406553,0.017166141,-0.09936823,0.023480298,-0.04210844,-0.06464206,0.060156014,-0.111234635,-0.005410345,0.0030374709,0.031294554,0.05593889,0.01336359,0.05131556,-0.046098076,0.03636181,0.038210098,0.029524546,-0.027584353,-0.0706844,-0.07679119,-0.013851621,-0.049963836,0.056061726,-0.040998302,-0.05999856,-0.07340858,0.0040216795,0.064348236,0.013368541,0.0020066113,0.015089041,-0.05457991,-0.01754115,0.0264532,-0.07481723,-0.05641646,-0.010312185,0.08846048,-0.09113103,-0.07598348,-0.06058107,0.011725266,0.0007017642,0.08671762,0.0825579 +1.14.14.149,A cytochrome P-450 (heme-thiolate) protein. Kinetic studies suggest that 1beta-hydroxyepiaristolochene is mainly formed first followed by hydroxylation at C-3. However the reverse order via 3alpha-hydroxyepiaristolochene does occur.,384,1.0,-0.05532177,-0.047423508,0.018817406,-0.054957535,-0.058214195,0.029186131,-0.0045994725,0.034729976,0.010954203,0.033812106,-0.000114347284,-0.007352001,-0.011791566,0.040289763,-0.021508424,0.05215172,-0.041683324,-0.0077028964,0.008409177,-0.02077402,-0.00525,-0.040132552,0.023936268,0.05257587,0.032249127,0.018284244,0.059970934,0.05990552,-0.014460305,-0.06603546,-0.048278525,0.008907097,-0.00905437,-0.015309809,0.005517081,0.09091001,-0.13177934,-0.084727935,0.030349486,-0.011336949,0.08386393,-0.029703587,-0.07336567,0.041413315,-0.010596575,-0.027150678,-0.011713885,0.08991904,0.036381036,-0.016867716,0.008281495,-0.082875825,-0.09219083,0.08032601,-0.0403194,-0.0072706537,0.030892618,0.067091845,0.00036117088,0.029426485,-0.049228333,0.066679046,0.0003802926,-0.012894475,0.07159553,-0.0686771,-0.006664401,-0.05779328,-0.014377712,-0.0040091597,-0.016560584,-0.060205042,0.03146042,0.030180339,-0.08305447,0.017466575,-0.016452465,-0.008146785,-0.026161999,-0.054719005,-0.02111119,0.009123852,0.0013897443,0.15131846,0.04235938,-0.014696306,-0.05146402,0.030640716,-0.064344734,-0.028677655,-0.00886712,0.053380553,-0.024150861,-0.007625234,-0.0673985,0.038533356,0.09490976,0.03635704,0.057886634,-0.049439274,0.07730798,0.05345798,0.0077282195,-0.04614349,-0.014848526,-0.00067390886,-0.023979709,0.0788667,0.04621681,-0.037394363,-0.018570015,-0.024517972,0.049517177,-0.049458764,-0.055347193,0.11116801,-0.026051214,-0.012865795,0.044793565,-0.056843046,-0.06796525,-0.030693356,0.021831669,-0.020864924,-0.09422557,0.03213542,-0.01783627,5.6805765e-33,0.07066369,-0.0027190107,-0.0111296475,0.07549442,-0.044864733,0.048403364,-0.045313694,0.03987036,-0.045533318,-0.044263218,-0.055435397,-0.06429767,0.027136335,0.02157805,-0.09898848,-0.04396373,-0.041606862,0.036493987,-0.014719542,-0.0032454296,-0.039712463,0.01706006,-0.022605391,-0.078140736,-0.04676213,0.041681677,-0.019649493,-0.022326391,0.03559416,0.0053209807,-0.028106676,-0.05947741,-0.09793296,-0.0122973835,-0.010482718,0.001838832,0.05126506,-0.016422434,-0.054456953,0.050411467,-0.012957927,-0.025305921,0.009874561,-0.14705102,0.089219466,0.0015888158,-0.109713726,0.020744013,0.029522963,0.008610002,0.05709938,-0.033025164,0.10395816,0.058102444,-0.107914224,-0.01909539,0.023395564,0.0076510846,0.037344303,0.050892524,0.11437167,0.102627955,-0.0064844564,0.09233094,-0.009341865,0.050459035,-0.039642528,-0.014005952,-0.05517778,0.108067736,-0.043597896,0.022719592,0.08117395,-0.019440806,0.09653892,-0.003834887,-0.023060324,0.073562466,0.013901556,0.030221174,-0.012792014,-0.028864836,0.010431134,0.001744022,-0.03663081,0.02765126,0.07832082,-0.018165013,-0.023583492,0.078420505,0.044519812,-0.10564573,0.024799101,0.0024914322,-0.003203757,-6.403991e-33,0.045760006,-0.09659327,0.014022316,-0.12113588,-0.05137516,0.008112922,-0.009156835,0.008076215,-0.025781553,0.03441167,0.18087046,-0.01427947,-0.068826966,-0.042142015,-0.016922187,-0.06000355,-0.042788867,0.021137377,-0.019997569,0.04515071,0.02179173,-0.060421195,-0.008138439,0.07900839,0.0465534,0.0025440014,0.039048173,0.009186169,0.0765538,0.027969014,-0.07453286,0.06028673,-0.057186376,0.0008554074,-0.04742381,0.03240871,-0.05988358,0.012294247,0.025768407,0.042260166,-0.056084108,0.05320979,0.014556979,0.0990221,0.07395912,0.08890414,-0.07748387,-0.016641323,0.04521774,-0.0033703404,0.029097544,-0.032127585,-0.013259943,0.037252024,-0.0008408989,0.043795917,-0.065383136,0.023806065,0.009763552,-0.07174471,-0.045930903,-0.012412594,0.009726809,-0.008508671,0.016951814,0.085813664,-0.0739213,0.048280608,0.07826487,-0.0014701812,0.019271448,0.040518075,0.019723272,0.035246767,0.014946741,-0.018693257,0.049928326,-0.0078018466,0.044237632,-0.039458387,0.036739264,0.056787528,-0.03796744,-0.054579955,0.011242232,-0.07454176,-0.072659895,0.074150726,-0.018304348,-0.039281517,0.007091211,0.06882858,-0.08164479,0.021465994,0.0523418,-4.189677e-08,0.009166355,-0.088408984,0.052489318,0.008648311,0.00036836774,0.015503172,0.035266608,0.014789765,0.0955067,-0.081332095,-0.03920291,0.05373078,-0.010341205,-0.067451,-0.028636923,-0.0020665736,-0.01894297,0.0016326461,0.004076645,-0.0033341546,-0.059960503,-0.02760391,0.0021885063,0.040258847,0.014300132,-0.045089297,-0.01836737,-0.049567506,0.0457654,-0.010606923,0.008700001,0.06480541,-0.027091354,0.028461661,0.056978993,0.038779505,-0.08584003,0.0062046275,-0.034091026,-0.052893557,-0.006076322,-0.08308757,-0.041494027,-0.0453546,0.06507365,-0.05388834,-0.0023776782,0.033960704,0.0021085332,-0.05220624,-0.029293336,-0.013934472,0.010238186,-0.095507845,-0.10433881,0.015572842,0.010832676,-0.06728634,-0.07681438,-0.11836483,0.04144863,0.005537206,0.19941545,-0.017231321 +1.14.14.150,"A cytochrome P-450 (heme-thiolate) protein from chicory plants. The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien-12-oate to give 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which spontaneously cyclises to form the lactone ring.",384,1.0,-0.03299741,0.015685186,-0.03255946,-0.040782522,0.064101554,0.10971016,-0.03527808,0.095142946,0.04836623,0.0057617924,0.047997244,-0.043231416,-0.0763745,-0.08464615,-0.033313792,0.01655136,-0.105091736,0.03582485,-0.029622564,-0.067624204,0.00073390076,0.02796858,0.013459731,0.0715185,0.018508539,-0.07840014,-0.007832751,0.051895868,0.006657047,-0.04841167,-0.03783005,-0.032326814,0.033846047,0.06439516,-0.030224625,0.07380201,0.051935647,-0.09508352,0.021421116,-0.021387134,0.056845546,0.022935342,-0.035255842,-0.032727275,-0.047671903,-0.012658206,-0.023242142,0.035763055,0.016604837,-0.05670619,-0.010360504,-0.08556952,-0.038997512,-0.012466119,-0.049828175,0.060385454,0.012199477,-0.038116693,0.08110101,0.07093972,-0.010722751,0.03898077,-0.010112831,0.051232744,-0.06308199,-0.07179848,-0.015030052,-0.0009903316,0.0064164023,-0.033875506,-0.0047584176,-0.10936709,0.03430221,-0.002554226,-0.0917092,0.13798569,-0.067189336,0.0058949315,0.02623301,-0.010296523,-0.007558839,0.0094915,0.03827184,0.11582833,0.0050340504,-0.045667194,-0.015626654,0.05826025,0.00027553263,-0.029654028,0.0020037584,0.011176638,-0.039212596,0.013129592,-0.1581733,0.0613577,0.16796212,-0.07466349,0.03176509,-0.03196041,0.047694158,0.017796561,0.0576202,-0.08729662,-0.05492263,0.040221244,-0.040019177,0.039232567,0.104250744,-0.05349697,-0.08154008,-0.010008373,-0.03208187,0.015429492,-0.06470848,0.07885718,0.005741995,-0.035558492,0.0046167825,-0.01832833,-0.018453013,0.015469693,0.0005835123,0.017440995,-0.019712461,0.006311173,-0.061962817,7.43513e-34,0.08821886,0.027196152,0.043653995,0.030640509,0.02902545,-0.046341117,-0.05465288,0.044693302,-0.04117123,-0.017932955,-0.03481344,-0.06673859,-0.007341907,-0.02839909,0.0056996066,0.08125673,-0.07400382,-0.03031738,0.030955527,-0.01278303,-0.10058172,-0.01717559,-0.013896685,0.023154998,0.040069856,0.07335763,-0.022730839,-0.053276926,0.04750581,0.018433025,-0.03974245,-0.076034956,-0.040059734,0.035747416,0.027215654,0.012174158,-0.0054140543,-0.021867797,-0.03214803,0.06690723,0.027461503,-0.03548246,0.03589743,-0.104758695,0.02892465,-0.039855715,-0.056850985,0.038994234,0.009452834,0.064907774,0.033692148,-0.06977795,0.045788575,0.11116198,-0.07400627,0.03974934,-0.013848785,0.05386648,0.04464502,0.03051497,0.11632843,0.019625647,-0.006898138,0.03758797,0.04380444,0.034682434,-0.057831306,-0.045259863,-0.020239795,0.101883195,-0.074997924,-0.036716625,0.010213886,-0.0057037463,0.05869503,-0.0038166423,-0.0315409,0.02063482,0.036630947,0.09177461,0.03722701,-0.024299959,-0.057207,-0.0047819694,-0.017611306,-0.010596142,0.0038342583,0.050320297,-0.04042249,0.064841725,0.086744785,-0.039414797,0.042742416,-0.010503028,-0.055595815,-1.30506175e-33,0.033659328,-0.032177325,0.027967948,-0.008671468,0.0037534975,0.027746689,0.0017388576,-0.06438607,-0.05457037,-0.07185118,0.08366211,-0.06433283,0.030812552,-0.022642512,-0.0244215,0.0036866658,0.0026558237,0.09760792,0.027637541,0.026649041,-0.005228022,-0.015338407,-0.04392748,-0.023728942,0.053250533,0.0239873,0.0059377044,-0.009056713,0.056163788,0.022360867,-0.030078677,0.04048792,-0.007996532,-0.04565581,0.0114343595,0.018192608,-0.022310406,-0.017352855,0.07674617,0.066091016,-0.058452856,0.030276034,0.030173412,0.044023596,0.03744138,0.09313969,0.0019496513,-0.018718334,0.0031549844,0.08661004,0.07740795,-0.0639067,-0.048405364,0.04015997,-0.021366121,-0.0004502004,0.026626518,0.028259547,-0.03630863,-0.0615504,-0.041365214,0.018638907,-0.07497794,0.011311651,0.0014752701,0.10323312,-0.032066084,0.050525717,-0.02429332,-0.0053616515,0.08489895,0.05607179,0.040145736,0.04999267,-0.067379765,0.00523836,0.025052328,-0.0744541,-0.03672486,-0.050594103,0.010486616,0.030293172,0.0058643366,-0.019333564,0.011353321,-0.025983132,-0.029071717,0.09794185,0.044550657,0.025788257,-0.025312534,0.029309675,-0.038821578,0.09668704,0.13242283,-4.4942e-08,-0.0039062626,-0.13028225,-0.06374812,-0.047470234,0.027925953,-0.00064215483,0.026336288,-0.0021307499,0.0057897535,-0.04585626,0.005428171,0.11524128,-0.029433925,-0.0047880397,-0.03786223,-0.03046269,0.040266264,0.055220068,-0.007911871,0.010805657,-0.0505625,-0.004199064,-0.030135406,0.010895752,0.024201438,-0.11738346,-0.003152873,0.041177846,0.038927786,-0.050797176,0.025314597,0.07137346,-0.04640066,-0.031326085,0.022790806,0.033172168,-0.055037044,-0.0759749,-0.0045017153,-0.053540878,0.02466173,-0.013745594,-0.113903955,-0.061426137,0.0059596775,-0.03951132,0.015468815,0.03600113,-0.018508105,0.019125685,-0.022382258,0.0038351396,0.040193003,-0.07293694,-0.07488536,-0.037303817,0.06576514,-0.049607392,-0.027720455,-0.0883664,-0.06230394,0.008425998,0.21428077,-0.050949942 +1.14.14.151,"A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plant Hyoscymus muticus also hydroxylates valencene at C-2 to give the alpha-hydroxy compound, nootkatol, and this is converted into nootkatone. 5-Epiaristolochene and epieremophilene are hydroxylated at C-2 to give a 2beta-hydroxy derivatives that are not oxidized further.",384,0.99999994,-0.0406026,0.05048926,-0.030923681,-0.022557642,0.038402162,0.08586116,-0.015774831,0.0644927,0.022350954,0.018863138,0.048553094,-0.038004417,-0.08524336,0.022625158,-0.06382349,0.062603295,-0.053559028,0.036506698,0.05982225,-0.025091957,0.01541267,0.045166,0.019237388,0.06468096,0.017030235,0.00062901963,0.000885657,0.05427034,-0.013605649,-0.10406797,-0.07103853,0.023238376,0.06392293,-0.0014039121,-0.0061476617,0.1122442,-0.023321649,-0.12726027,-0.027578866,-0.014477345,0.08850243,0.014450425,-0.09465641,0.07871912,-0.05444393,-0.014030976,0.0015742965,0.0042750672,0.022504078,-0.0076314197,0.009593553,-0.09168212,-0.061921068,-0.0035540576,-0.043074004,0.036890425,-0.0011372968,0.067037195,0.01617648,-0.026502995,0.009038493,0.035477016,-0.017110907,0.018877037,0.03167852,-0.055267137,-0.041363265,-0.01808564,0.0029469114,-0.048586674,0.0052742,-0.078934684,0.014672286,-0.0017773263,-0.09916342,0.034352854,-0.07135474,0.010174604,0.032586344,-0.011041746,-0.007996068,0.01882359,-0.028571252,0.1078881,0.049232647,0.016334608,-0.05805442,0.0521997,-0.011748164,-0.052869715,-0.00017685609,0.009258947,-0.040503204,-0.012602158,-0.08531716,0.04605614,0.062314406,-0.010579597,0.008382221,-0.0170052,0.0710016,0.0670706,-0.0077784825,-0.106819466,-0.0471634,0.017126895,-0.04090538,0.015359844,0.08164235,-0.023482947,-0.07655801,-0.0059974063,0.03759929,-0.043865766,-0.06564119,0.07182615,-0.014228956,-0.014079466,0.005929364,-0.013802868,-0.044512704,-0.024889272,-0.0075665046,0.011525767,-0.09860767,0.03511855,-0.07205196,5.3524074e-33,0.088899896,0.0018181646,-0.028931372,0.06114275,-0.0029013504,0.005021733,-0.03378025,0.010716433,-0.01638472,-0.070791185,-0.10412186,-0.02147047,0.034558825,-0.0045509376,-0.015921518,-0.06808261,-0.046361577,0.051861748,0.12266072,0.04716942,-0.05967447,0.051519837,-0.066585295,-0.006702085,0.021901524,0.018655844,0.017519182,-0.03142632,0.028420338,0.010907149,-0.037495643,-0.06295637,-0.021679077,-0.049554776,0.0427001,-0.02754688,0.0021920593,0.004047358,-0.025113933,0.008850722,-0.015306946,-0.02028713,0.0134247495,-0.061874874,0.05168799,-0.01814691,-0.083373025,0.023350943,-0.0056910114,0.014313413,0.07048781,-0.061406437,0.0460207,0.08852498,-0.08429456,0.015842138,0.00594792,0.037308842,0.010790466,0.03979089,0.1089292,0.11567027,-0.0038258072,-0.002865657,0.011365687,0.025522824,-0.104968235,-0.0332583,-0.027688896,0.1075093,-0.03413518,-0.023617864,0.06404417,0.008368378,0.034761228,-0.009689562,-0.05428085,0.0479766,0.07676541,0.024915654,0.023888469,-0.044258725,0.0027572277,-0.02815647,0.0034621176,-0.014151942,0.05956694,0.013457876,-0.018612584,0.038702436,0.07928434,-0.09980656,0.020122457,-0.015560996,-0.003362278,-5.336151e-33,0.06749494,-0.103698246,0.04476236,-0.0701413,-0.054896004,0.058422476,0.024293005,-0.077923745,-0.0008483266,0.039094694,0.13441877,-0.01619754,-0.010650276,-0.022782065,0.039570738,-0.01328526,-0.037205905,0.059203804,-0.03685645,0.044398893,-0.0156069435,-0.0008854087,-0.06594312,0.05070288,0.017138867,0.054390173,-0.019382365,0.012888027,0.067583874,0.03549236,-0.068439394,0.0028275459,-0.06453021,-0.026489817,-0.011440838,0.011306144,0.001549084,0.021220613,-0.00012920905,0.002660323,-0.024115326,0.07307089,0.046365906,0.07840177,0.051267557,0.06160023,-0.08129198,-0.03372927,-0.01735716,0.0048767147,0.047308795,0.010890049,-0.046990804,0.05322456,-0.043869924,-0.03096426,-0.07082265,-0.003579056,-0.011546616,-0.06877344,-0.0155905215,-0.09284642,-0.058498252,0.06772034,0.0061905277,0.06799253,-0.061139256,0.042230397,0.013324488,-2.8636864e-06,-0.007123933,0.01599419,0.09703064,0.07155112,0.00772612,-0.007402445,0.02176183,-0.05546465,0.018855598,-0.059652667,-0.015895728,0.019396482,-0.048966758,-0.05657565,0.04764375,-0.09174815,-0.011736641,0.0761565,0.04693593,0.003870306,0.0044866763,0.07055584,-0.07704694,0.064750075,0.12516597,-4.960188e-08,-0.025862202,-0.12333492,0.03468159,-0.00886968,-0.009745484,-0.04506987,0.013020615,-0.005161159,0.10932771,-0.042480994,-0.010936118,0.09484431,-0.04472732,-0.02635426,0.02693273,0.022894418,0.05351972,0.060948066,0.037163414,0.01737018,-0.09400271,0.012208009,-0.034564972,0.044524495,0.0231386,-0.09823101,0.048856065,-0.027133545,0.05880392,-0.03098819,0.05674818,0.058074974,-0.044409644,0.0155147435,-0.009427839,0.058856223,0.005408968,-0.012301277,-0.0375348,0.019033639,-0.048043884,-0.067775235,-0.08292772,-0.012716404,0.03584755,-0.054970853,0.05767914,0.05167525,0.004533366,-0.021016883,0.012736471,0.01311956,0.002692014,-0.1463931,-0.10763403,-0.04045542,0.02546199,-0.028652111,-0.05689753,-0.100809984,0.003594226,-0.0051343846,0.22508074,-0.04964673 +1.14.14.152,"A cytochrome P-450 (heme-thiolate) protein from the plant Glycyrrhiza uralensis (Chinese licorice) that participates in the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-beta-amyrin to 11alpha,30-dihydroxy-beta-amyrin but this is not thought to be part of glycyrrhizin biosynthesis.",384,0.99999994,-0.11001635,0.017751615,-0.075450845,0.010170832,0.02318027,0.053413056,-0.045431674,0.033408534,0.0060963747,-0.038600363,-0.0016764118,0.06355673,-0.04331021,-0.008463458,-0.07717706,0.015917854,-0.08263063,0.047966007,-0.0650976,-0.038168713,0.02385898,0.05329869,0.026056353,0.031276744,0.02957181,-0.06837789,-0.009519772,0.110588275,0.028522767,-0.029969584,-0.014208129,0.005617222,-0.0001901979,0.014009512,-0.011808954,0.10079972,-0.0606664,-0.08893945,0.06370584,-0.018093057,0.08722109,-0.02963257,-0.07404675,-0.007888346,-0.012586191,-0.016404036,-0.033794306,-0.03135477,-0.03524458,-0.049415603,-0.015213734,-0.044504467,-0.03003324,0.030059958,0.024085835,0.013392932,0.02265923,-0.024794936,0.03243416,0.009265832,-0.02332275,0.0816123,-0.018551217,0.029364925,-0.0792157,-0.051760465,-0.06791268,-0.0038936036,0.008963016,-0.06355166,-0.01822515,-0.08579775,-0.03493139,-0.018208204,-0.11075028,0.046886187,-0.042284366,0.009416795,-0.032250214,-0.029572163,0.051269352,-0.043952085,0.070613205,0.13866478,0.013519343,-0.057464004,-0.012730768,0.058512285,-0.031665847,0.0072261216,0.054855876,0.008765089,0.045560583,0.0022102306,-0.0806963,0.03353732,0.06611652,-0.1122993,-0.025323713,0.00031006132,0.009822951,0.0638801,0.034493454,-0.13528825,-0.030507063,0.02140064,0.0015133397,0.06458272,0.07399014,-0.08057753,-0.055532265,0.0048077484,-0.022064464,-0.023407476,-0.0055146394,0.06039442,-0.01924616,-0.015642976,0.0045672944,-0.04523551,-0.022802237,-0.007689304,0.013727487,0.00841564,-0.028797565,0.00748997,-0.08545013,4.503413e-33,0.11902998,0.06337541,-0.008311795,-0.039626986,0.01595067,0.0053149518,-0.046847343,-0.007058173,-0.00527628,-0.053803682,-0.056513816,-0.07305559,-0.056908082,-0.0141639905,-0.008500637,0.055537224,-0.11964102,0.010993508,0.0870639,0.037164386,0.0006456184,-0.057813942,-0.07019119,-0.06602369,0.047916964,0.06988217,0.005271957,0.0229581,0.027276775,0.017902689,0.014182854,-0.035347458,-0.10502341,-0.03141643,0.052691568,-0.02821637,-0.012500533,-0.0026046745,-0.018343534,0.044606816,0.009952068,-0.041957427,-0.012343154,-0.06557673,0.08540708,0.084762454,-0.08481044,0.027377259,0.0045541828,0.10308375,0.05475399,-0.07196238,0.1088642,0.046109162,-0.08560204,0.007642726,0.00641757,-0.028533954,0.021910436,0.07342286,0.09382772,0.029518928,0.020555383,0.025841968,0.051851388,0.06423497,-0.045292318,-0.022980366,-0.058484994,0.07401623,-0.027351445,-0.078818314,0.07951684,-0.041921485,0.012701853,-0.028536715,-0.03952691,0.007298388,0.016127396,0.024546891,-0.0062091975,-0.0028134596,-0.019561883,-0.056487042,0.022296637,0.029074099,0.014098109,-0.03859353,-0.038345236,0.016192619,0.1022244,-0.061414953,0.05909709,-0.0028449928,-0.051586367,-5.2141693e-33,0.09984599,-0.08244017,0.03580306,-0.06201646,0.008809091,-0.006318804,0.01795863,-0.025945762,0.021130446,0.058560554,0.056027476,-0.03452336,0.009492604,-0.004032236,-0.009402313,-0.020712264,0.018896874,0.103255406,-0.004655613,0.022726756,-0.012522477,-0.009106265,-0.02229822,-0.011216537,0.033514947,0.063637145,0.023637282,-0.005647771,0.015394498,-0.0034534798,-0.042012393,0.0459098,-0.08777634,-0.053726923,-0.06055078,0.06902828,-0.074521974,-0.0068217693,0.016856564,-0.016408846,0.0028854525,0.025283236,0.023635633,0.10386381,0.08682237,0.026072016,-0.058849093,-0.035062183,-0.017036397,0.017838746,0.04991944,0.030983789,0.0040924554,0.09129356,-0.033391602,0.027873525,0.012667823,0.028663572,-0.037077256,-0.044197127,-0.032081265,-0.007931243,-0.028597007,0.05538255,-0.00018038906,0.074844375,0.020741852,0.08903498,0.051755115,0.010623187,0.05613105,-0.021638948,0.09169139,0.09940809,-0.015599557,0.06117618,0.0044839745,-0.031673457,0.012962891,-0.007306119,0.03320623,0.029168166,-0.060700327,-0.037797105,-0.07331719,-0.13351472,-0.035814032,0.14689995,0.049127568,-0.027107337,-0.005882275,0.08486265,-0.03350076,0.03760238,0.051798645,-4.0737596e-08,-0.007837083,-0.10581535,-0.00028435985,-0.026030684,0.04169733,-0.022514615,0.019413251,0.03340101,0.045719754,-0.0085864505,0.0071301465,0.08101731,-0.042814415,-0.007654013,-0.042362683,0.031744685,-0.0027218475,0.05012488,0.03458288,0.016525086,-0.0861359,0.048273567,-0.046001606,0.049584445,0.020570338,-0.13573217,-0.031972796,0.013878717,0.004731798,-0.011088232,0.0579114,0.08264712,-0.052996162,-0.025254255,0.029456018,0.042130377,-0.044288263,-0.07440847,-0.0021168776,-0.08967998,-0.057617646,-0.0651123,-0.027656874,-0.036466688,0.000730809,-0.036927607,0.023457566,-0.0036096103,0.009300486,0.015404141,-0.0196867,-0.006641112,0.022019261,-0.1363062,-0.08979831,0.022615861,0.02989131,-0.05125426,-0.064431615,-0.056931246,-0.020283826,0.029726338,0.19364218,-0.0028714193 +1.14.14.153,"A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).",384,1.0,-0.09918082,0.057978753,-0.052081846,-0.028475152,0.045059193,0.101815574,-0.0012057868,0.0837863,0.037524957,0.01598472,0.040334057,-0.0022475836,-0.040126543,0.0024149877,-0.056053944,0.08147508,-0.049337726,0.01908755,-0.027751755,-0.079380795,-0.027447352,0.090139344,0.03313592,0.023312282,-0.014426131,-0.013098231,-0.016419014,0.06815265,-0.012954616,-0.051570993,-0.029300056,-0.015204411,0.09004193,-0.02288825,-0.003168156,0.09915677,-0.060770568,-0.088444114,0.023567036,-0.011971036,0.079201326,-0.022642974,-0.10042722,0.023625508,-0.05439369,0.006328173,0.04402703,0.04854074,-0.00058662536,-0.02249312,0.011744713,-0.028704645,-0.046538826,0.010868814,-0.057250515,0.012304297,0.023676807,0.024666173,-0.071696095,-0.043312345,-0.030243564,0.04028815,-0.05415165,0.03638041,0.00657713,-0.05200328,-0.013009462,-0.009351916,0.015662251,-0.08360305,-0.020756336,-0.09914341,-0.039482683,0.04572321,-0.112126246,0.09013561,-0.06529455,0.017124435,-0.0068267733,-0.031992648,0.0637786,0.012006118,-0.007214276,0.10901385,0.06270825,0.0065780003,-0.03463358,0.08799748,-0.018286765,-0.035528895,0.007817663,-0.047438692,-0.0299624,0.044773318,-0.103852876,0.07911729,0.061353203,-0.058275655,0.0011241644,-0.022115272,0.0645199,0.047706455,0.046137225,-0.09246214,-0.05770794,0.012470043,-0.049222194,0.024483258,0.042754345,-0.08718717,-0.07175594,-0.020856645,-0.009209781,-0.022198077,-0.0040254705,0.05671795,0.008640791,-0.034421816,0.0065345373,-0.017116584,-0.061182316,-0.006080076,0.008335292,0.06351233,-0.032914203,0.02995268,-0.14827047,9.9663655e-34,0.10182551,0.025411723,-0.0221921,0.015656726,-0.039835263,0.018679002,-0.06189119,-0.0042946464,-0.05334947,-0.00038470456,-0.07963497,-0.10830841,0.05334182,-0.065617345,-0.02817999,0.009223544,-0.06683308,0.033626374,0.056916084,0.009097138,-0.07598818,0.021468582,-0.09065979,0.021042803,0.027838847,0.110799104,0.004920781,-0.051869538,0.0025495347,0.0032007785,-0.0480891,-0.06347974,-0.07079486,-0.04425673,0.033678003,-0.031672195,-0.049370784,-0.04057355,-0.043311354,0.043757707,-0.05247641,-0.032767992,0.032147013,-0.040987097,0.059735637,-0.02553588,-0.14110251,0.055846523,-0.00026397384,0.062405556,0.07515623,-0.073932305,0.13377467,0.050833248,-0.09314967,0.0049318066,0.01653058,0.075272165,-0.002193335,0.054528654,0.09603882,0.04653793,-0.0739723,0.04045766,0.034870204,0.01137726,-0.06736016,-0.015981086,-0.020902228,0.1640933,-0.028678702,-0.034809597,0.031034674,0.004385971,0.053971846,-0.026671981,-0.0010599956,0.06569466,0.048800252,0.08146071,0.013094977,-0.04131228,-0.018341599,-0.05571471,-0.04787155,-0.0023235104,0.05278749,0.0050909724,-0.0196724,0.0074441317,0.08829586,-0.06810587,0.014680745,0.01447787,-0.0053605046,-2.0761041e-33,0.07703547,-0.040484864,0.054835923,-0.071308106,-0.021437977,0.048579343,-0.016576558,-0.0425703,-0.013463749,0.034496047,0.06840228,-0.025788175,0.018057417,-0.0046400973,0.027897952,-0.029348286,-0.028245382,0.040438343,0.009232983,0.072174676,-0.05862056,-0.024205035,0.020335255,0.03318698,0.022105897,0.007071608,-0.018654406,0.0035027966,0.046229083,0.017424446,-0.039957236,0.020841766,-0.07765828,-0.026495242,-0.019643923,0.037270363,0.007214088,0.02255355,0.035010155,0.019866232,-0.0416018,0.048648257,0.07662014,0.07196687,0.0408345,0.08879701,-0.0982837,-0.024778733,-0.062901825,-0.0007553492,0.025802258,0.060750514,0.03937734,0.06617481,0.005461642,-0.017993053,-0.013044036,0.012553991,-0.047208484,-0.041517496,-0.010703137,-0.03158539,-0.034220427,0.1066403,-0.022973277,0.07193631,-0.058319107,0.0656651,0.0036032586,0.006211196,0.011560382,0.010904744,0.043709405,0.06155793,-0.014539141,0.015336598,0.021475893,-0.02920856,0.030112078,-0.0052460516,0.002037399,0.01888836,-0.05356198,-0.05785992,-0.015722943,-0.07380701,-0.056169827,0.119143784,0.06398656,-0.02834427,-0.0094815595,0.0711629,-0.04110628,0.06318708,0.055299416,-3.4050903e-08,-0.032808788,-0.09526097,-0.00019547023,-0.035396084,0.0383708,-0.023042217,0.013914899,-0.002919575,0.060760453,-0.00872802,0.00016932053,0.038385857,-0.0352624,-0.011122377,0.04870069,0.016039629,0.024893073,0.02536336,0.028206205,0.049332973,-0.035492823,0.029122692,-0.047888312,0.0426745,0.04862024,-0.07243344,0.013030913,-0.040357754,0.055427667,0.012813913,0.045201994,0.038654692,-0.049650837,-0.00590655,-0.015609985,0.076112956,-0.0039792564,-0.06806348,-0.023151219,-0.018268168,-0.022986092,-0.059179813,-0.058123067,-0.03773824,0.03826862,-0.005025452,0.030454468,0.024695408,-0.017092135,-0.020521903,-0.040761787,0.0061095,0.019467391,-0.099318124,-0.12125942,-0.004532937,0.076570824,-0.0540726,-0.015211017,-0.09118583,-0.02581718,0.010934289,0.2125189,-0.007907828 +1.14.14.154,"This cytochrome P-450 (heme-thiolate) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.",384,1.0,-0.04610581,0.06584978,-0.042011853,-0.056139186,-0.01163372,0.030399734,-0.05748777,0.08482121,-0.0072976756,-0.012416203,0.029262887,-0.0025444408,-0.04969227,0.02303995,-0.020365775,0.04984066,-0.080479026,0.007749797,0.017054256,-0.04333855,0.033110134,-0.021095145,0.015524962,0.02316135,-0.026851362,0.066471905,0.093900174,0.08129651,-0.026709532,-0.07495855,-0.006478869,-0.051166475,0.084347494,-0.025766386,-0.010346942,0.093001485,-0.07134865,-0.06583546,0.010276051,-0.0019502133,0.07681122,-0.047600925,-0.09852431,-0.006864056,-0.014558881,-0.08385725,-0.000626007,0.050855216,-0.023543317,-0.020710602,0.015419038,-0.07827534,-0.032019153,0.056822516,0.0024299189,0.032981195,-0.031607714,-0.0072109103,-0.044224128,0.013949756,-0.005186241,0.05098117,-0.100332394,0.03636305,-0.034410767,-0.008231328,0.007115341,-0.036404002,-0.058285665,-0.013616554,-0.027134145,-0.06881857,-0.03221669,0.009178282,-0.085589975,0.07497814,-0.05286974,-0.02673684,0.039273985,-0.031990808,0.027327463,-0.041554935,-0.019467479,0.111996874,0.11921932,-0.022074414,-0.017505286,0.030358683,-0.008088833,0.02226996,-0.0024700724,0.049567427,-0.032077286,0.011915024,-0.13201909,0.050150115,0.034049477,0.045440428,-0.016861819,0.011999295,0.069470905,0.10530729,-0.042069085,-0.093207695,-0.11609928,-0.017108759,0.046793807,0.04939294,0.04877195,-0.076224744,-0.05901824,-0.016634809,0.019375682,-0.044796016,-0.026896585,0.13148879,-0.013477479,-0.01529209,-0.02817006,-0.05500781,-0.036154572,-0.027661784,0.010288321,0.059059232,-0.04776323,-0.018254414,-0.06104727,2.163955e-33,0.10094919,0.03940798,-0.00820644,0.00018871896,-0.01053187,0.02693967,-0.05266912,0.051551007,-0.069836415,-0.024303677,-0.026467407,-0.07550045,0.05824934,-0.011064411,-0.058499556,-0.08542444,0.02155591,0.07346564,0.077140465,-0.008417236,-0.044493377,0.03334083,-0.046483353,-0.008309079,-0.012494997,0.08917572,-0.026540792,0.034666225,0.02200765,0.028249942,-0.035109393,-0.038441885,-0.07725438,-0.016982237,-0.029769495,0.022219164,-0.010652087,-0.04098822,-0.011697327,0.07296393,0.009580408,-0.03961201,0.058167398,-0.042743947,0.059985083,-0.0043836017,-0.11420924,0.06120339,0.077737294,0.04395374,0.07582872,-0.023895377,0.0689985,0.032111358,-0.06888364,0.08184403,-0.026605532,0.022000141,0.007794715,0.04498251,0.14851949,0.063504465,-0.026364837,0.04177152,-0.009800821,0.059464626,0.0047150664,-0.08880612,-0.056654796,0.11328526,-0.033321742,0.07517286,0.053328164,-0.0020769017,0.02899625,0.02904675,0.016161272,0.05587736,0.055465672,0.03316498,-0.04781961,-0.019221177,0.016108332,-0.055020202,-0.0035838275,-0.0017860557,0.028561294,-0.014447461,-0.0012439453,0.07868761,0.046334848,-0.10491649,-0.036786318,0.027150111,0.025485454,-2.3544206e-33,0.05283735,-0.07916217,0.033275135,-0.11981285,-0.062044054,0.04100912,0.030888336,-0.03282889,-0.021081079,0.0150445895,0.1257374,-0.042135876,0.017927853,-0.03300487,0.0019445765,-0.036051936,-0.015874755,0.009124051,-0.028548228,-0.0040927175,0.034134403,0.046575963,0.03533284,0.07129002,0.03971487,0.035724815,0.020481823,0.014456508,0.08394313,0.059924908,-0.026331073,0.011841236,-0.0032290576,-0.0109530175,-0.043109216,0.12348624,-0.0003055405,0.02068792,-0.002141851,-0.0027877213,-0.08398172,0.013582208,0.005505108,0.031171016,0.022508916,0.0911479,-0.01932527,-0.024055043,0.01892123,-0.057091672,0.05055027,0.05262269,-0.030110283,0.043032523,-0.037004504,-0.0012073555,-0.057438508,-0.04347899,0.008742531,-0.13604744,-0.005849318,-0.02424119,-0.010034672,0.023556532,0.021792233,0.053813897,-0.06015871,-0.0089136865,-0.011731099,0.00490987,-0.025853014,-0.026997024,0.0032633725,0.09305462,-0.019486627,-0.016027847,0.018488372,-0.06011059,-0.00696647,0.0071377777,0.0047429423,-0.022953436,-0.043076493,-0.098941416,-0.075004615,-0.08011027,-0.025236538,0.08126844,0.0022645774,0.012088921,-0.035767727,0.086173326,-0.06979168,0.078588784,0.03764831,-3.9965492e-08,-0.03219437,-0.09918276,0.025754564,-0.003144713,0.026147714,-0.010110106,0.007751611,-0.03158172,0.111028075,-0.08297935,-0.036585305,0.056656264,0.013919708,-0.025585035,0.004394594,0.0070916354,0.009294731,0.0076656677,0.021766499,-0.05582003,-0.05868677,0.010337539,-0.007837296,-4.0891046e-06,0.06875936,-0.060878452,-0.0626921,0.03489808,0.019034335,-0.0014440066,0.07430627,0.049772166,0.005080439,0.025866583,0.0038827094,0.09854996,-0.035658497,-0.011443827,-0.025436973,0.033904847,-0.033184737,-0.10202796,-0.060899273,0.03104684,0.0127946995,-0.028766034,0.04302981,0.031281378,0.010871366,-0.010007519,-0.019111628,0.0018539807,0.06302775,-0.09799462,-0.08103783,0.0139727285,0.03391176,-0.05830547,-0.039013397,-0.051261004,0.0484787,-0.04023812,0.20697321,-0.014402795 +1.14.15.31,A cytochrome P-450 (heme-thiolate) protein involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.,384,1.0,-0.07056865,0.024908856,-0.16807817,0.029310113,-0.033440236,0.10528795,-0.012713651,0.1066763,0.03800994,-0.06978838,-0.05202839,-0.039612133,0.01010896,0.051332213,-0.09723837,-0.060382355,-0.044891205,0.014841945,0.09199408,-0.09870826,-0.018907864,0.100636594,0.08164393,-0.004503365,0.023596704,0.023243567,0.017558064,0.073598936,-0.050423354,0.027503237,0.0006746589,-0.028644638,0.0016875389,-0.017957574,0.06190324,0.08117398,-0.022212526,-0.06427738,0.086215,-0.01685325,0.02471724,0.004412124,-0.07814485,0.10019631,-0.035910923,0.00023788077,0.00470858,0.05538623,0.029939111,-0.065180294,-0.0014782142,-0.057190783,-0.057545774,0.060487356,0.035394065,0.023831412,0.030951533,-0.0062119695,0.050348934,-0.07155595,0.065683186,0.01659232,-0.025687221,-0.04177967,-0.047652617,-0.026993634,0.041221637,-0.035536796,0.004344142,0.01729301,-0.050046965,-0.013431922,-0.014639611,0.037071224,-0.104997456,0.09073046,0.0164228,-0.046380017,-0.09472082,0.025615849,0.08050217,-0.009189319,0.014049812,0.09973836,0.011419835,-0.015907347,-0.0054193554,0.07472726,-0.012947614,0.024311317,0.0065142503,0.031923953,-0.01297928,-0.039175853,-0.10558824,-0.042380534,-0.013704794,0.024988081,0.04659923,-0.05792415,0.032896675,0.016090678,0.03401602,-0.023608582,0.0010399637,0.012595099,0.023616638,0.11222856,0.041587226,-0.09855206,-0.039414573,-0.0025894765,0.02208003,-0.07113727,-0.0019212618,0.07422437,0.0079563875,0.018499987,-0.04842533,0.07073658,-0.03713526,0.053651057,-0.020227775,0.008401404,-0.029265007,-0.021566598,-0.12171749,1.180724e-33,0.050554883,0.07758693,0.04488816,0.017972149,0.048266478,0.0332714,-0.097561784,-0.010650167,0.030254398,0.015359082,-0.040796652,-0.10027548,0.020545991,-0.0129566705,-0.0013377506,0.016616443,-0.060857464,-0.0007637169,0.034436684,-0.009076491,-0.03547808,0.014328687,0.003572599,-0.0548595,0.012041239,0.07842947,-0.015239765,0.04669885,0.026045468,-0.023801878,-0.04443961,-0.04621091,-0.06600383,-0.043885298,0.09842966,-0.084896415,-0.013574778,-0.021990487,0.022770204,0.029666137,-0.034371216,-0.03094244,-0.013382419,-0.022036292,0.04763104,-0.044102047,-0.09945029,0.079670854,-0.0045061386,0.07602726,0.039392993,-0.100510314,0.05527313,0.0470891,-0.105244644,0.0076562134,0.0035696852,0.06988496,0.009416002,0.044099674,0.10944257,0.017373431,-0.026361998,0.031637438,0.05823368,0.056091484,-0.037377078,0.00466903,-0.020614458,0.103101715,-0.05243433,0.024174923,0.046895634,-0.016739056,0.04187221,0.0008428521,-0.09845063,0.032372203,0.060171023,0.020347744,-0.03225868,-0.022667862,-0.07637794,-0.06758604,-0.027785862,0.06276555,0.032205343,0.0040131975,-0.006598715,0.07409486,0.016992701,-0.13089326,-0.011574791,0.0028169078,-0.024894314,-2.166633e-33,0.0977432,-0.03377717,-0.012247243,-0.05206051,-0.05485139,0.04371465,-0.03429396,-0.0673804,-0.10328064,-0.03584901,0.11831684,0.0093997605,-0.03558454,0.02286112,-0.031325825,-0.056161053,-0.019151287,0.014659432,0.007135953,0.023815429,-0.01260729,-0.053246364,-0.034096453,0.028150693,0.028435167,0.005860328,-0.0011618347,0.042630035,0.042819962,0.057735816,0.022689266,-0.010887158,-0.080425024,-0.090598546,-0.028494148,0.06055562,0.017218398,0.026082652,0.088851295,0.006521027,0.002295603,0.045566745,-0.010203626,0.082162,0.050676074,0.11744348,-0.0067424746,-0.061390232,-0.01487543,0.0044232514,0.0204785,0.038219467,-0.041980866,-0.012731477,-0.0595593,0.00029441505,-0.02033662,0.017231662,0.06164321,-0.021627147,0.012329129,-0.034513567,0.023307793,0.029679252,0.054815717,0.047192328,-0.0019040904,0.069793865,0.15492167,-0.037904963,-0.0066937525,-0.025256764,0.043549687,0.082300514,-0.063039154,0.009919219,0.046078112,-0.022133986,0.08079085,0.0017550305,0.0008854879,-0.032860734,-0.049723055,-0.072602145,0.004618403,-0.02644541,-0.01903344,0.0527455,0.008562683,-0.018279577,-0.010111671,0.03970965,-0.007067695,0.01631279,-0.010124053,-2.6363535e-08,0.04443104,-0.06767654,0.03521051,-0.024794659,0.07286538,-0.025611155,0.009387963,-0.042310033,0.0305579,-0.005816245,-0.018556887,-0.02773291,-0.042159274,0.008365157,-0.05577493,0.031986486,-0.05572508,-0.02050954,0.06434898,0.013032214,-0.09426823,0.013511033,-0.088435136,0.06713783,0.06913632,-0.11180027,0.021245481,0.04012708,0.06579494,0.031432074,0.069287516,0.0070246994,-0.04086196,-0.023753466,0.023164714,-0.013372755,-0.122875735,-0.040198788,-6.5688335e-05,-0.07330639,0.02618727,0.027289318,-0.06919517,-0.0080907205,-0.03382373,0.011963201,0.032787587,0.015503557,-0.08349499,-0.018510843,0.040249933,-0.006973681,0.0034846247,-0.006330697,-0.10717354,0.026923724,0.06597822,-0.03445755,-0.06780989,-0.039441876,-0.057895612,-0.031438526,0.11126786,-0.049929395 +1.14.15.32,A cytochrome P-450 (heme-thiolate) protein found in the bacterium Streptomyces avermitilis. The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics.,384,1.0,-0.059048854,0.038692717,-0.109091476,-0.025060343,-0.02858043,0.04842016,-0.032707237,0.09017678,0.058234487,-0.032795113,0.008191482,-0.0133881,-0.023814915,0.07956213,-0.051796265,-0.038151722,-0.044834767,-0.038271267,0.070483655,-0.07016104,0.045220934,0.08715382,0.031305023,-0.045257285,0.032692306,0.027821878,0.0010702314,0.057004653,-0.02652077,-0.06087024,0.022179913,-0.021132084,0.07820336,-0.0906889,0.103156775,0.09350991,-0.05965642,-0.058813054,0.101569384,-0.013246998,0.030578109,-0.0155693125,-0.018786594,0.093616016,-0.051048175,0.01666204,0.045418203,0.100807115,0.0073524443,-0.06422439,-0.0043578143,-0.062016204,-0.057313412,0.059065595,0.019009372,-0.0029045173,0.062316414,-0.05024443,-0.018539876,-0.1058131,0.0328542,0.07001916,0.013681322,0.0086447215,-0.07321784,-0.010358019,0.025272578,-0.045479257,0.053461123,-0.027496863,-0.02607878,-0.028527234,-0.006414489,0.049702294,-0.054702092,0.047918368,-0.047115795,-0.025184793,-0.06851325,-0.0059308778,0.04721861,0.015698329,-0.036681876,0.14366288,0.072719656,-0.04938912,-0.003763837,0.018252997,-0.004814791,-0.001901109,0.030732503,-0.016207475,-0.04348614,-0.04386589,-0.116223715,-0.0112646995,-0.031617798,0.005660649,-0.0027899905,-0.022939883,0.023628846,0.04156053,0.018051608,-0.019467127,-0.027063614,0.0095975585,-0.03267418,0.055778723,0.07191665,-0.09857888,-0.04267904,-0.012099266,-0.010406061,-0.0545028,0.021314552,0.023548322,0.036539424,-0.04528317,-0.021802455,0.0042410265,-0.05272496,-0.0018979463,-0.025380034,0.021717263,-0.007020642,0.02388845,-0.15205619,2.5185514e-33,0.043012436,0.03195769,0.029370964,-0.0249276,0.023342242,0.026088465,-0.06691859,-0.004162713,-0.0074331565,-0.036178473,-0.10175568,-0.11143296,0.020235024,0.010121447,-0.025068546,0.015585956,-0.057462458,0.080299355,0.049657635,0.017513294,-0.0005856842,0.01354858,-0.047806576,-0.033137884,0.044508398,0.1146543,0.00036357547,-0.008963205,0.08097038,-0.0020863686,-0.025354961,-0.046847343,-0.082172126,-0.060299933,0.061710827,-0.07381022,-0.009531314,-0.052523255,-0.009643758,0.046323825,-0.03158153,-0.008046718,7.754473e-05,-0.032984637,0.100326315,-0.019787038,-0.10340512,0.045121647,0.025413325,0.033192825,0.06096444,-0.07851508,0.105431594,0.040996145,-0.083475545,0.013538916,-0.013452556,0.075893104,0.039534774,0.04692352,0.093632534,0.07554873,-0.018123316,0.007880851,0.03461732,0.049945757,0.0026634566,-0.036942575,-0.025737936,0.11525685,-0.092966616,-0.013928052,0.027189195,-0.018722145,0.0295964,0.010346263,-0.07290969,0.034100544,0.08057589,0.027284877,-0.020699568,-0.04868964,-0.03476385,-0.09048036,-0.009440579,0.0037109768,0.047817197,-0.05795407,-0.007966748,0.07980862,0.01366238,-0.10061811,-0.067686714,0.053460985,-0.03203264,-3.3016492e-33,0.06189281,-0.10129569,0.06742809,-0.07672285,-0.08721594,0.072960064,-0.052245386,0.012579118,-0.017215677,0.0015986616,0.09985462,-0.026978366,-0.010655509,-0.02232624,0.011470911,-0.020169798,-0.016750017,0.04964953,0.0042774566,0.07095016,-0.009506955,-0.013236182,0.022580374,-0.008063927,0.039681863,0.036303937,0.023939725,0.01573632,0.03328294,0.0025211154,-0.0186684,0.02042006,-0.07283359,-0.07360428,-0.088756144,0.075116344,0.012244675,0.016818855,0.075504646,0.028633289,0.046035655,0.0711188,0.04668251,0.08303692,0.040152814,0.08639491,-0.116402306,0.007578092,0.027580477,-0.03446228,0.048297826,0.0040757074,0.0053185667,0.024553798,-0.021271054,-0.011926112,-0.04158713,0.016600681,0.004441345,-0.04136816,-0.036888927,-0.060474433,-0.0005808248,0.06374615,0.054442078,0.030164486,-0.02850769,0.079884395,0.071613945,0.0015574602,-0.005232944,0.021390036,0.005998376,0.042552713,0.007613856,0.03235878,-0.032711387,-0.04129672,0.06711983,0.0072797816,-0.015624098,-0.037708588,-0.02451883,-0.039135236,-0.018564321,-0.07004803,-0.0039031669,0.10556737,0.042320274,0.00895775,-0.037233084,0.06955909,-0.013115491,0.04343727,0.04767503,-3.221142e-08,0.023172924,-0.04356038,0.06065976,0.00072259316,0.057298914,-0.03813832,-0.0076278257,-0.027224898,0.034700703,0.0010620051,0.0020343254,-0.0058475924,-0.029396923,-0.058812574,-0.009367304,0.056528103,-0.045281116,-0.056354046,0.048172563,0.01202378,-0.018716969,0.018281775,-0.041350987,0.04616054,0.070579536,-0.091991425,0.057033513,-0.02566239,-0.0053098793,0.0065450477,0.005428858,0.005959849,-0.064048946,0.025112655,0.011761742,-0.0005214488,-0.112447836,-0.08171264,-0.008378937,-0.03000981,0.024025401,-0.04031154,-0.06952252,-0.03650756,-0.008391507,0.03670344,0.025234561,0.017736165,-0.090649664,-0.07457513,-0.0039511253,0.013143861,-0.0042582233,-0.001667755,-0.13473105,0.03133089,0.035062216,-0.048887365,-0.08191214,-0.077309474,-0.004011902,-0.037667558,0.196145,-0.02076412 +1.14.15.33,A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin. ,384,1.0,-0.08653374,0.03393119,-0.06225093,-0.09295905,-0.019405108,0.029517207,-0.013937036,0.13105898,0.038986146,-0.0121177165,-0.0066913282,0.022207323,0.09417869,0.10258937,-0.039246056,0.0018041546,-0.025504358,0.022946741,0.009367599,-0.01848361,0.00065447536,0.048317198,0.05021983,0.030297767,0.0255271,-0.02351571,0.015432372,0.06960666,-0.067558505,-0.035704404,0.071355514,0.04066633,-0.01661417,-0.021345831,0.067442976,0.07052528,-0.114265285,-0.01629276,0.09438795,-0.0023721692,0.027206097,-0.008925526,-0.009606088,0.07222894,0.0132447835,0.0020273498,-0.07620055,0.048119266,0.039546188,-0.021955654,-0.025612816,-0.016518127,-0.076706834,0.11682453,0.07452215,0.043592807,-0.072358504,-0.08610541,-0.021333966,-0.033611737,0.013108803,-0.0013720097,-0.011898102,0.041911907,-0.0552058,-0.055972055,0.019767819,-0.04716039,0.013297572,0.019049406,-0.050121162,-0.0747769,-0.0075869183,0.029252023,-0.061120395,0.0003235094,-0.052072342,0.012798186,-0.06368776,-0.0367898,0.036515296,0.024467265,0.007749344,0.10044357,0.072473414,-0.0500806,0.050576985,-0.0050755898,-0.04140427,0.033385996,0.0159023,0.015993344,-0.0005128153,-0.033505682,-0.1408437,-0.05460433,0.006537386,0.018219016,0.0045913355,-0.008023248,0.03796823,0.06537204,0.0024768908,-0.07269379,-0.04168677,-0.02648971,0.031550713,0.06257598,0.018637158,-0.033350524,-0.04793302,-0.034656193,-0.007091099,-0.058051378,-0.025725504,0.12239152,0.10591085,-0.01333964,-0.011089315,-0.055121753,-0.03843536,-0.03627271,-0.016287273,-0.043361325,-0.059007958,0.050263844,-0.08414215,5.5757205e-33,0.07217321,0.023726141,-0.034044456,0.05064718,0.04090337,0.02211456,-0.084204145,-0.0058929897,-0.042253535,-0.035675813,-0.072799586,-0.011187566,0.020139415,0.06283962,-0.04539458,-0.004238104,-0.055185355,0.04797321,0.013099208,0.0068354495,-0.0045834165,0.028430436,-0.024532566,-0.017309034,0.042278517,0.13132344,-0.09645249,0.029296275,0.0072904993,-0.00039143598,-0.064280644,-0.030847896,-0.057552807,-0.010251486,0.03618263,-0.036663808,-0.017160216,-0.04872253,0.089125164,0.010216279,-0.057441596,-0.050022874,0.012342577,-0.07222171,0.07918915,0.007579311,-0.09105577,0.06122084,-0.02064271,0.048502937,0.103555635,-0.064565115,0.056601882,-0.013271789,-0.08091331,0.040684734,0.003865356,0.040066965,-0.029581193,0.06379803,0.11507549,0.040702846,-0.0071903775,-0.0007059949,0.08493038,0.039543997,-0.044787392,-0.025161995,-0.035794765,0.08844674,-0.086934805,0.044276442,0.09414471,0.014783351,0.07194038,0.028868096,-0.047390167,0.019114403,0.08457265,0.04541881,-0.0188848,-0.005607073,-0.051092412,-0.015778307,0.00796271,-0.016884403,0.039317004,-0.05649573,-0.0054519586,0.009716604,-0.014515804,-0.14253287,-0.011592851,-0.0011618931,-0.028456956,-7.09958e-33,0.07599728,-0.033214167,0.027442247,-0.03976615,-0.01654925,0.06467825,0.039162774,-0.0603639,0.014019667,0.025362356,0.09902986,-0.01743062,-0.07267072,-0.018663844,-0.03405435,-0.058983747,-0.026902556,0.026500486,-0.058095362,0.022384768,0.02271318,0.021972135,-0.019689409,0.014392303,0.008488275,0.050497208,0.016677,0.018617775,0.090179525,0.06629695,-0.059342094,-0.0032516515,-0.077201925,-0.07077338,-0.0708167,0.13296808,-0.03099494,0.026354743,-0.0063657444,-0.038841072,0.006405884,0.03627036,-0.023303377,0.03963352,0.02495804,0.05323987,-0.046250366,-0.018226406,0.027151464,-0.030497197,0.0383084,0.04053174,0.0367347,0.08284451,-0.080549,0.03568611,-0.007899516,-0.0059771417,0.00562284,-0.033246946,-0.07677167,-0.02138647,-0.019837832,0.026154527,-0.0368402,0.05447634,-0.06884862,0.030959273,0.05576674,-0.028085353,0.0037992646,0.0314056,0.042126883,0.0023467878,-0.013100262,0.03473976,-0.015737483,-0.07191604,0.020019094,0.059352316,-0.017007353,-0.006891061,-0.0513551,0.01123756,-0.044780307,-0.03852893,-0.034687296,-0.0016230734,0.034297217,-0.0683597,0.010844547,0.081931055,-0.03649083,0.06162632,-0.010759511,-4.3022563e-08,0.036007445,-0.041070998,0.053820048,-0.02842797,0.071266755,-0.0041537676,-0.036101636,-0.04200604,0.038424212,-0.038432423,0.02007414,0.10305934,-0.057333425,-0.06367992,-0.018971816,0.062032383,-0.0069817225,0.022957625,0.027337888,-8.115506e-06,-0.07460175,-0.001597052,-0.05818012,0.050712083,0.04254594,-0.061728522,0.013602708,-0.006544633,0.010832091,0.008644813,0.074051864,0.032398976,-0.083080545,0.008800408,-0.007898559,-0.032979824,-0.11244577,-0.057463683,0.029796416,-0.029592797,0.019990198,-0.046591084,-0.1368787,0.03393793,-0.0034807192,0.019138008,-0.017409885,-0.028680997,-0.07490238,-0.0012794187,-0.00057518954,0.027881049,-0.002677684,-0.06999419,-0.118861504,0.042057637,0.036025383,-0.080873385,-0.061979104,-0.09401685,-0.058800142,-0.004575847,0.202201,-0.007827885 +1.14.15.34,"A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.",384,0.99999994,-0.045498528,0.030353792,-0.07398934,-0.019272106,-0.0008121224,0.069044076,-0.024301931,0.12053837,0.046413027,0.0014213021,-0.027286446,-0.026609253,0.035664897,0.08446325,-0.053493813,-0.012127181,-0.060142916,-0.014591928,0.013490622,-0.07146604,-0.0028860013,0.09154241,0.081199676,0.024609312,-0.017763661,-0.0063251434,0.009859735,0.057132944,-0.05235336,-0.0282847,-0.029437069,-0.018969074,0.06833936,-0.057653822,0.063296996,0.08967901,-0.03030344,-0.035303943,0.120376356,-0.05621077,0.0306417,-0.040373623,-0.04536298,0.07109049,-0.007246087,0.023741411,0.030193035,0.04341857,0.049184244,-0.016582835,-0.03865633,-0.025239047,-0.042915408,0.06767726,0.043267224,0.030851996,0.022572953,-0.048040386,-0.00047600668,-0.10439159,0.009496991,0.0096539445,0.021318683,0.022390025,-0.06825774,-0.039598074,0.016926955,-0.0165741,-0.008141657,-0.038841125,-0.03958379,-0.06213513,0.014263082,0.06100638,-0.06550273,0.054890815,-0.007345824,-0.04971669,-0.050634876,-0.0021947115,0.07948334,-0.022286678,-0.041164994,0.14166252,0.04393085,-0.066655874,0.017959353,0.01826379,-0.007701176,0.023354707,0.0023154425,0.006177203,-0.00020967325,-0.051328152,-0.12005568,-0.031267047,-0.055820942,0.0053469897,0.056238387,-0.013272762,-0.009687911,0.06633244,0.04782559,-0.04269189,-0.01023561,0.011179196,-0.009397446,0.080358155,0.08858209,-0.082715265,0.0060720975,-0.032276142,0.03213543,-0.039699677,-0.01809453,0.05978047,0.0590108,-0.008920935,-0.012186672,-0.021496298,-0.0032669595,-0.0046792473,-0.0023812584,0.0049950317,-0.018380472,-0.030200299,-0.08548853,7.718752e-34,0.07517473,0.02194235,-0.009589152,0.020623975,0.041274816,-0.005308382,-0.083643176,-0.028798731,-0.025122048,0.008405268,-0.09848936,-0.14571597,0.025274968,0.0394643,-0.033667084,0.01638453,-0.05754164,0.06703624,-0.008417082,0.032645136,-0.042637404,0.049718726,-0.02349455,-0.0122969095,0.06850316,0.14604683,-0.01651744,0.0132197505,0.034286115,-0.02481117,-0.008205659,-0.021591816,-0.06727252,-0.017703839,0.062057912,-0.056399595,-0.012454027,-0.025506828,0.020141073,0.015489913,-0.031284876,0.012876224,0.0020785732,-0.073254555,0.06266236,-0.040360946,-0.07641866,0.048950713,0.028681366,0.049846847,0.105678186,-0.109516725,0.062801026,0.030352749,-0.044474866,0.0014249139,-0.004039712,0.08561938,0.06480653,0.059032355,0.07288768,0.03241235,-0.02069041,0.047008943,0.074032694,0.03326942,0.0040864013,-0.017643973,-0.020413872,0.090517454,-0.06344128,0.03774539,0.030870013,-0.008573117,0.001331621,0.024387265,-0.06766943,0.011482181,0.105726525,0.015507685,-0.014170854,-0.043660503,-0.025890049,-0.040522013,-0.012612329,0.08574932,0.03343501,-0.04376613,-0.02742503,0.010088532,-0.018008456,-0.124772415,-0.052287035,0.014549448,-0.061574746,-2.4869583e-33,0.081043385,-0.06384457,0.031930786,-0.09009312,-0.1125724,0.05578276,-0.0718783,-0.029206995,-0.044351373,-0.0071482724,0.117042966,-0.056035593,-0.019278523,0.0026502954,-0.0071002026,-0.07043486,0.018690623,0.00833889,-0.07054624,0.025682766,-0.017213158,-0.032161802,0.023112724,-0.01184211,0.045744672,0.04774307,-0.02242141,0.05410964,0.029319055,0.050179716,-0.059913453,-0.003085831,-0.046471883,-0.07401459,-0.033542015,0.11903527,-0.00884361,0.008118536,0.072417445,-0.0031868154,0.05678548,0.04316897,-0.00015501112,0.062621936,-0.01808049,0.115703546,-0.08154211,-0.004549225,0.039892543,-0.049589537,0.024108592,0.026464015,0.03269044,-0.013220827,-0.06439227,-0.009914898,-0.016175374,-0.025004385,-0.00608336,-0.054245133,-0.016473457,-0.03191635,0.05904722,0.03795146,0.010627322,0.08271663,-0.06696282,0.050960936,0.06678248,-0.020982996,-0.003497542,0.038384378,0.052126672,0.053175747,-0.005233908,-0.003919246,-0.024635946,-0.051824626,0.08856836,0.060469374,0.0026240703,-0.0057337317,-0.056340203,-0.02959102,-0.012942257,-0.05914724,-0.06322167,0.066662736,0.04093685,-0.031317174,-0.02839988,0.08318386,-0.02124875,0.03587271,-0.02223133,-3.010157e-08,0.06551039,-0.051020544,0.036690142,-0.033873077,0.022157226,0.0024919412,-0.041060492,-0.024405163,0.040411707,-0.04387893,0.013203483,0.040749345,-0.06877395,-0.049302906,-0.017314052,0.026672691,-0.056233983,-0.031585485,0.013013038,-0.043428905,-0.04794037,0.0012783154,-0.04348793,0.04977295,0.09437224,-0.0935434,-0.00055358047,-0.035418954,0.0029641255,-0.021186143,0.04316963,0.030058078,-0.07184251,0.02592559,0.029330645,0.003153549,-0.1018011,-0.0673447,0.0043551573,-0.018175682,-0.004198713,0.0020893777,-0.124544576,-0.021530451,-0.04410971,0.025481874,0.015483275,0.033136774,-0.08657055,-0.035786156,0.034822583,0.0321567,0.03450893,-0.013114353,-0.16212445,0.04685749,0.07115074,-0.04090784,-0.050702304,-0.073444396,-0.005966432,-0.07130777,0.19081828,-0.029805003 +1.14.15.35,A cytochrome P-450 (heme-thiolate) protein isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin.,384,1.0,-0.077277675,0.048184045,-0.11234532,-0.026579209,0.042698603,0.019620936,0.0064640488,0.11375748,0.058722254,-0.03433241,0.000998261,-0.033882976,0.026061082,0.06885407,-0.012034843,-0.0021539913,-0.041525494,-0.018679416,0.027402945,-0.07735497,0.00097169395,0.060231812,0.0523387,0.039666712,0.013682864,-0.015400064,0.06711877,0.06884205,-0.083431125,-0.04000383,0.001703271,-0.06166616,0.060460027,-0.029716752,0.048088763,0.11229401,-0.070634395,-0.037899982,0.08358729,-0.04148518,0.03554355,-0.014872612,-0.061190154,0.08132256,-0.04147695,0.035895973,-0.018469838,0.040663164,0.043037407,-0.040660787,0.0016810584,-0.01542662,-0.05271577,0.049641684,-0.0004742851,-0.021535723,0.022057856,-0.024601981,-0.018980095,-0.039545048,0.027154109,0.039420433,0.016650358,-0.0050578713,-0.084900744,-0.03622865,0.018367475,-0.0429036,0.021321699,-0.044925123,-0.079414085,-0.06951171,-0.01506434,0.099213645,-0.062080417,0.017329955,-0.0019725845,0.026235923,-0.003305686,-0.0136480285,0.069415346,-0.011427503,-0.0032225023,0.16270651,0.05247872,-0.0073881946,0.027393226,0.03677796,-0.011487486,-0.034728233,0.034928393,0.025365477,-0.017296284,-0.023283152,-0.10399974,-0.009143495,-0.028144427,0.0068349685,0.014453635,-0.008031205,0.025902748,0.056481875,0.034087382,-0.082349285,-0.07128733,-0.027981766,0.0076883687,0.08298621,0.04805744,-0.10914363,-0.019595249,-0.02649851,0.010151391,-0.04758171,-0.037256178,0.097587615,0.043980267,-0.03423149,-0.048055377,-0.013239217,-0.035215426,0.012897021,0.051077064,0.019903626,-0.022862194,-0.010111875,-0.1318971,3.2202425e-33,0.06212181,0.042935487,-0.032089226,-0.008325154,0.004058834,0.012694179,-0.045410287,0.03202944,-0.018015241,-0.005650191,-0.069182724,-0.10986274,0.0058070878,-0.015954133,-0.044986106,0.03097432,-0.015507499,0.050645057,0.033312783,0.0019953144,-0.044165064,0.015276396,0.020797703,-0.060748633,0.05935177,0.097272694,-0.05069007,-0.013593891,0.07539649,-0.01641631,-0.014551881,-0.09183591,-0.051352132,-0.02735656,0.06995459,-0.047238983,-0.018411987,0.02149793,-0.009751481,0.028477365,-0.04419593,0.05382338,0.040771063,-0.06554031,0.074354276,0.006997622,-0.11387939,0.063677035,0.016679587,0.034758966,0.06223271,-0.09215253,0.09164543,-0.0014472823,-0.081512235,0.009945563,0.02661603,0.085432455,0.035577066,0.04109222,0.1026278,0.089315034,-0.0401654,0.029312124,0.07551305,0.059341457,-0.03201156,-0.037745386,-0.070877336,0.13194248,-0.067813545,-0.013953528,0.056325335,-0.021782087,0.005176542,-0.012805955,-0.059707694,0.011745036,0.053197213,0.04512023,-0.012198167,-0.026321426,-0.0334347,-0.043198064,-0.028122684,0.031413898,0.050843634,0.0041157,-0.041322645,0.06130481,0.028711813,-0.110590056,-0.018153569,0.022759845,-0.018151483,-3.5604163e-33,0.09323614,-0.04011937,0.027510986,-0.10556973,-0.011617281,0.07241333,-0.003959907,0.013053695,-0.034525074,0.04812774,0.1368762,-0.041144874,-0.027503774,0.01872599,0.009435168,0.0035632872,-0.006627038,0.05510157,-0.03215448,0.062468175,-0.0037005213,0.029157914,0.027889863,-0.031098088,0.023870287,0.028791606,0.019081894,0.04024056,0.01778948,-0.02109077,-0.08402644,0.011589961,-0.06829436,-0.08314962,-0.08669763,0.050860666,0.009395146,-0.03330351,0.05346948,0.0034834791,0.007965972,0.06702681,-0.031623695,0.07465465,0.038040016,0.073383026,-0.08041281,0.020631384,-0.004966612,-0.019308213,0.02914782,-0.018283442,0.009618913,4.6189452e-05,-0.061281014,-0.0014541707,-0.004198112,0.07001799,-0.020539083,-0.049329385,-0.06620178,-0.05099353,-0.0025332093,0.05374965,0.014176396,0.08789505,-0.07440792,0.028746665,0.06922837,-0.02704582,0.038914636,-0.014651538,-0.010506397,0.051874902,-0.008399866,0.003182721,-0.009219132,-0.0422499,0.051671628,0.056153134,0.0039934563,-0.00629253,-0.04927242,-0.02877092,-0.010377694,-0.0688687,-0.034092266,0.07641316,0.0364417,-0.0118175205,0.015096991,0.06275242,-0.008129583,0.077614136,0.035903018,-3.1779013e-08,0.0030577611,-0.081805386,0.019814827,-0.03942927,0.035881024,-0.025980994,0.015800348,-0.023682183,0.014314284,-0.010516404,-0.006567096,0.066210255,-0.06093278,-0.0189702,0.026407516,0.028794726,-0.016182387,0.011109611,0.041896097,0.012593908,-0.005467603,-0.0027950758,-0.055170685,0.025708344,0.08444858,-0.11204254,-0.014075929,-0.09183466,-0.018785652,-0.016833544,0.02521315,0.030788165,-0.061281387,0.023427567,0.02930254,0.005018242,-0.13372049,-0.058465328,-0.030162346,0.022486808,0.0056842617,-0.0071991757,-0.09831987,-0.01789325,-0.016637152,0.028191725,0.041025776,-0.009546639,-0.0574291,-0.052334633,-0.0041445484,-0.03730923,0.017422875,-0.08777572,-0.15494812,0.033226132,0.059044342,-0.06833799,-0.047906794,-0.08252441,0.011593533,-0.024596952,0.22275504,-0.020177899 +1.14.19.62,A cytochrome P-450 (heme-thiolate) protein. Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids.,384,1.0,-0.053263206,-0.054788094,-0.02901914,-0.012017207,-0.06212614,0.059067085,0.015758077,0.06654113,0.06265021,-0.014263805,0.047275517,-0.064624205,-0.026175372,0.026126115,-0.025601013,-0.014888725,0.023671705,0.035125367,0.018062562,-0.06334744,-0.048541643,0.031295076,0.03915621,0.00604548,0.0015239676,0.053072575,0.03561526,0.09516336,0.024465438,-0.011467493,0.02937401,-0.0011379301,-0.0026275755,0.013449217,-0.022250533,0.023545597,-0.07718335,-0.0028567885,0.10416583,-0.009845498,0.05218544,-0.0723403,-0.059790507,0.06590331,0.013155067,-0.07293962,-0.06937399,0.01786831,0.07546809,-0.061469197,0.039360024,-0.054477137,-0.065979935,0.07999817,-0.015666343,-0.034332167,0.020997409,0.014646638,-0.026742203,0.044464618,-0.0067207175,0.04924833,-0.0009917024,0.022342369,0.0045087016,-0.016754141,-0.0011007125,0.04368187,0.07124864,-0.017335817,0.011232132,-0.062352277,-0.025032194,0.04004378,-0.104207225,0.0724305,-0.039865285,0.0037441396,-0.11376155,-0.12909731,0.111556694,0.07023939,0.046593867,0.15291724,0.021321738,0.0131494505,0.049005445,0.06496284,-0.0824287,-0.024707489,0.023559107,0.066928126,-0.04091203,-0.016430058,-0.045615654,0.013087576,-0.016684437,0.028553246,-0.02149312,-0.016544944,0.058324117,0.06763785,-0.111008584,-0.07786314,0.015685152,0.0037560835,-0.004662857,-0.0112164365,0.0825403,-0.04555587,-0.021236481,-0.040771924,-0.03868993,-0.012728289,0.0020527751,0.057253134,-0.01398368,0.07728575,0.025094105,0.033540078,6.971512e-05,0.039740585,-0.057892147,0.035590827,-0.08794333,-0.048586432,-0.027029209,2.067704e-33,0.09700072,0.02361001,-0.038528945,0.020729635,-0.05482671,0.018279234,-0.05309498,-0.0071963165,-0.096314095,-0.018534105,-0.11066831,-0.05112195,-0.03452826,-0.0026831245,-0.019458711,-0.047764026,-0.1379913,0.02204569,0.087128654,-0.08261688,-0.08660753,0.031654947,-0.039610464,-0.013919024,0.000201945,0.07345945,-0.0043025375,0.03951497,-0.009835939,-0.012617945,-0.08023319,-0.03489738,-0.019661954,-0.039811056,-0.014002097,-0.06377272,0.04266987,-0.020471727,-0.052438226,0.024141353,0.013074311,0.02711903,0.015192026,0.021644473,0.054353055,-0.015890406,-0.12390884,0.062403597,0.022997055,0.0053533614,-0.01224455,-0.053712245,0.07554002,0.053687483,-0.116443895,-0.01096006,0.005435456,0.027037343,-0.049699605,0.031838134,0.07285519,0.037909076,-0.06193385,0.030219683,-0.00851533,0.08980591,-0.029565208,-0.028529974,-0.004645751,0.091814026,-0.056647677,0.04889507,0.021362128,0.02321943,0.10725535,-0.0012311633,0.0021114727,0.076031834,-0.030081308,0.0059036133,-0.057492245,-0.051344093,-0.029223457,0.014469515,-0.04948106,0.015715783,0.028960483,0.049039286,-0.018638037,0.023084112,0.038061474,-0.0026798889,-0.043608207,0.076572046,-0.09810147,-3.2236195e-33,0.022833077,-0.047931314,-0.0205359,-0.057612725,-0.111744955,0.06605958,-0.067861825,-0.014771398,-0.031494353,0.06477628,0.11271595,-0.009602712,0.088735156,-0.038012017,-0.05486314,-0.038492803,-0.0480601,0.08604112,-0.01965409,0.081565045,-0.022213275,0.019518923,-0.019699985,0.03555712,0.10752335,0.043467335,0.05821577,-0.0101449955,-0.035291787,0.06901815,0.027257046,0.0148711065,-0.12606628,-0.055317394,-0.08286663,0.032094132,0.0431653,-0.019525247,-0.018343953,0.025735006,-0.045606196,0.10670266,0.019566461,0.08961051,0.06768662,0.018976547,-0.031395882,0.010981068,-0.058025952,0.023882639,0.034330107,-0.0007981616,0.038411375,0.00697734,-0.026771896,-0.0059392317,-0.04713952,-0.032647617,0.059637483,-0.024886733,0.0024798135,-0.050314274,-0.0034059046,0.023818022,0.011768939,0.053140793,-0.004141001,0.09155024,0.069009654,-0.035024107,0.06966208,-0.019115675,0.033786595,0.034572266,-0.024625069,-0.0013669938,0.066642635,-0.055855367,-0.0018047775,-0.0028660991,-0.0057302443,0.051077556,-0.035324924,-0.05018124,-0.010384085,0.008484281,-0.006503458,0.11081097,0.029130254,-0.011146386,0.01652322,0.06486447,-0.04001637,0.034114037,0.013922193,-2.8360366e-08,0.08030037,-0.018278278,0.00625409,0.031206103,0.054401025,-0.027093131,0.022937963,-0.03846805,0.007459395,-0.036248844,-0.025786916,0.025343956,-0.055024777,0.025988795,-0.0031218883,0.024887502,0.04527831,0.04411139,0.041720077,0.028587045,-0.025474895,-0.016506936,0.006138916,0.025266385,0.013868779,-0.10494217,0.0018847652,-0.012703847,0.048896518,-0.019527072,-0.0012477406,0.028418012,-0.019297766,-0.0064799176,0.010183412,0.09791482,-0.05832273,-0.00971762,-0.006541068,-0.043706425,-0.06521915,-0.13077016,-0.032828182,-0.0316397,-0.0055519203,-0.032718033,0.10084865,0.03424041,0.04184002,-0.062098615,0.006568454,-0.047674164,0.035243392,-0.08040133,-0.12948254,0.02856275,-0.029843729,-0.006461709,-0.012510334,-0.15034157,-0.029114516,-0.044454813,0.121839605,0.0006584393 +1.14.19.63,"A cytochrome P-450 (heme-thiolate) enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Catalyses a step in the biosynthesis of (-)-maackiain, the main pterocarpan phytoalexin in chickpea (Cicer arietinum).",384,1.0,-0.060128987,0.02398595,-0.1038577,0.010661557,0.040311273,0.05200699,-0.040119573,0.00632658,0.028402336,0.00930639,0.018435836,-0.017884979,-0.035447273,0.010904121,-0.09076687,0.041025247,-0.07129637,0.021452595,0.00961095,-0.04622433,0.010294762,0.046539787,0.030757165,0.055836007,-0.05113793,-0.018392934,0.018631808,0.05895758,-0.052439004,-0.016230222,-0.075039454,-0.036860295,0.059822083,-0.047642265,-0.035814483,0.11937751,-0.06683175,-0.037529834,0.060253352,-0.042648558,0.052224893,-0.07829285,-0.05881602,0.019560976,-0.021090211,-0.07519857,0.017171718,-0.01661206,0.033289626,-0.086536065,-0.067653164,-0.0278147,-0.11285083,0.025903793,-0.00018269705,-0.012628414,0.008821407,-0.0009792158,0.023604115,-0.054418582,0.0023844976,0.045062084,-0.042973883,0.015986651,0.01409287,-0.088274784,-0.021417206,-0.03446834,-0.0437356,-0.04475537,-0.017066224,-0.08209151,-0.03498485,0.008282945,-0.041584313,0.07783797,-0.050696943,-0.008679563,0.0010210057,0.05022945,0.02433254,0.007527684,-0.041153733,0.095507994,0.09252512,0.028263986,-0.05605818,0.023886096,0.013714543,-0.030163998,0.057505812,0.07049686,-0.009577446,0.028416164,-0.06505505,0.014287731,0.03596601,0.023646642,0.0076338467,0.008642536,0.049058564,0.062164772,-0.094274655,-0.08016533,-0.016888883,0.010776533,0.0077971895,0.03821769,0.09149594,-0.03732261,-0.07187004,-0.08728294,-0.027410474,-0.020761693,0.005575495,0.12414026,-0.014585815,0.0094233975,0.040938083,-0.022201963,0.0030734458,-0.0162278,0.028716136,0.043610435,-0.07429046,0.023125002,-0.11504363,4.1665144e-33,0.067966044,0.027185973,0.02154399,0.043482848,0.055857234,-0.02239129,-0.094868965,-0.04924858,0.026024079,-0.016078308,-0.12042062,-0.04123854,-0.027205756,-0.021119697,0.05465009,-0.036563553,-0.05595672,-0.00090111996,0.06341071,0.047347087,-0.032986525,-0.0055394075,-0.04813527,0.046343274,0.044423446,0.10534429,0.0027345915,-0.05258223,-0.025421737,0.023604931,-0.021811625,-0.04766176,-0.06260982,-0.0830427,-0.04656579,-0.051937755,-0.027698865,-0.043068815,-0.058411647,0.0539454,-0.115863495,-0.055264622,0.01809269,-0.023407476,0.03439293,-0.006836581,-0.07265687,0.10467817,0.026748963,0.06070814,0.043991596,-0.05739459,0.107837126,0.031746365,-0.085955314,0.018010173,-0.015329907,0.011325069,0.07225137,0.079121366,0.058203697,0.027112326,-0.0065587997,0.04337011,0.004946374,0.039395176,-0.07849404,-0.02341633,0.019846857,0.120148845,-0.034293175,0.04763478,0.027956214,-0.034549203,0.050609693,-0.0046924297,-0.0037434972,0.061486613,0.023912843,0.00042420105,0.04066306,0.013524519,0.015814543,-0.007953783,0.014630147,0.049016856,-0.010116227,-0.0042033624,-0.025799546,0.038435783,0.061668716,-0.0075243586,0.01825946,-0.053538874,-0.025918372,-2.9125246e-33,0.10064944,-0.06170775,-0.030164577,-0.105201185,-0.057535686,-0.02931748,-0.07104219,-0.06469172,0.00032260624,-0.029927447,0.0020483886,-0.084046386,0.04893001,0.0072846897,-0.012430419,0.032765914,-0.0035147287,0.048085637,0.018932639,7.893189e-05,-0.03284118,0.017264092,-0.022586687,0.0047830422,0.053366225,0.013002939,-0.020574357,0.037421405,0.0886487,-0.0046027396,-0.05127126,0.0151530085,-0.040809546,0.031152219,-0.073041335,0.12521295,0.020965748,0.056610554,0.058247257,0.116084635,0.050516624,0.03784696,0.021741936,0.04646834,-0.007916281,0.070764795,-0.06779936,0.010356681,-0.020662451,-0.07065851,0.10014199,0.05021459,-0.004770793,0.010932961,0.055795275,0.05809463,0.032479424,0.0005672967,0.012863,-0.042345755,-0.0047736815,-0.022320934,-0.014003318,0.02776094,0.030441446,0.085929245,-0.012872628,0.057282895,0.03543081,0.008681826,0.076868095,-0.009480752,0.0065013836,0.036917478,-0.0040676263,0.020406205,0.0054731756,-0.010512939,0.07447075,0.04213548,0.01817266,0.0022056557,0.01637046,-0.11244459,-0.058401357,-0.058292314,-0.021806808,0.12645209,0.011984885,-0.0075239246,-0.008617644,0.062464975,0.008871539,0.051387362,0.05977259,-3.5092036e-08,0.037772696,-0.087724656,0.034192815,-0.031163787,0.0448604,0.022666099,0.05058553,-0.012650346,0.07988624,-0.049120158,-0.013063788,0.0031773704,0.027594421,-0.019175647,0.0004851234,0.07452644,0.023031926,0.03166081,0.023368053,0.012077212,-0.10243604,0.053876653,-0.103193596,0.019590193,-0.020532468,-0.10399735,0.022597762,0.043904588,0.015442203,0.005551003,-0.022388615,0.06846483,-0.03028835,-0.0690135,-0.05244174,0.012286766,-0.048537694,-0.054048732,-0.0094597,-0.039107207,-0.06774617,-0.056594715,-0.058133464,-0.038533106,-0.0015672249,-0.0128296055,0.03008332,-0.0072686127,-0.013973554,-0.020219859,0.03604335,0.044660345,0.07314179,-0.06685723,-0.09267466,0.01634043,0.09649994,-0.01449524,-0.028591866,-0.09953857,0.013856606,0.041831434,0.24113268,-0.018437183 +1.14.19.64,A cytochrome P-450 (heme-thiolate) protein catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the second methylenedioxy bridge of the protoberberine alkaloid stylopine from oxidative ring closure of adjacent phenolic and methoxy groups of cheilanthifoline.,384,1.0,-0.039155614,-0.0058751707,-0.062194724,-0.006464184,0.02618829,0.08225685,-0.009389879,0.06568729,0.034541465,-0.0147798015,-0.013248784,-0.022026481,-0.03505941,-0.06258766,-0.033704188,0.09995449,-0.08659801,0.022581527,-0.04341308,-0.05085013,0.011829083,0.040755928,0.048140805,0.0044305013,-0.01414383,0.03205476,0.025666254,0.063968495,-0.011055506,-0.012274611,0.008045704,-0.006252756,-0.0009355019,-0.0069800233,0.012670929,0.054132685,-0.07244796,-0.046067625,-0.009658143,0.001073908,0.038143285,-0.005429482,-0.11415621,0.050707094,-0.041588977,-0.05855105,-0.0028617964,0.028903509,-0.012475686,-0.040736858,-0.025639927,-0.022051884,-0.09517738,0.059072036,-0.025121985,0.059140727,0.024398962,-0.008412732,-0.019679666,-0.012781728,0.027464794,0.017569484,-0.031090891,-0.024150651,0.010362274,-0.04748885,0.00056923454,-0.022136243,-0.0032078726,-0.08490079,-0.049825136,-0.056580372,0.013487685,0.0075603933,-0.041342936,0.050698522,-0.020186339,-0.0132379355,-0.00955475,-0.025089659,0.05184414,0.019890076,-0.06899102,0.12057218,0.055022094,0.009952596,-0.042884503,0.021272536,0.008954894,-0.029613229,-0.013932278,0.01141332,-0.03139434,0.006826842,-0.12131243,-0.008752015,0.07585856,0.027908446,-0.016948003,-0.0050371755,0.03645163,0.05199218,-0.019741157,-0.108468585,-0.031314746,0.022503003,-0.027919684,0.058333877,0.02651368,-0.047620848,0.011200353,-0.08543379,0.010168244,-0.0166513,0.017536841,0.108988084,-0.039387174,-0.04233587,0.016129367,-0.027714206,-0.05761186,-0.00112079,0.015360228,-0.002497039,-0.08800071,-0.011441368,-0.068687275,7.382009e-33,0.08919063,0.049985223,0.010339765,0.051750883,0.019811325,-0.022057334,-0.15167826,-0.0014660815,-0.016461145,-0.006933887,-0.088057905,-0.03565338,0.009972529,-0.056458894,0.020303767,-0.027604114,-0.121036515,0.037173837,0.05260985,0.022447906,-0.051132474,-0.01626818,-0.024330016,-0.009133679,-0.004459841,0.07628076,-0.008979668,-0.030133475,-0.012040688,0.031990778,-0.07069428,-0.059701666,-0.045855764,-0.06005498,-0.054333422,-0.009303421,-0.014464351,-0.050281946,-0.04583129,0.06280695,-0.051654764,-0.025385782,0.017089287,-0.017341204,0.07689042,-0.062210362,-0.11222295,0.07544365,0.03245646,0.085025616,0.00049991906,-0.08197504,0.12501733,0.082676046,-0.12447193,0.016047774,-0.041487023,-0.0036921236,0.03424523,0.0676322,0.049385823,0.047002822,-0.0025681814,0.05527153,0.042388692,0.06933586,-0.019535689,-0.03472573,-0.011423248,0.11672791,-0.06893371,0.02390482,0.052376777,0.019291444,0.012550404,-0.025086237,0.0005414147,0.11708189,0.11083976,0.0635744,0.048706327,-0.02565631,-0.059180494,0.0078636985,0.018714156,0.018191738,0.029397892,-0.030906219,-0.04905675,0.08592694,-0.012620648,-0.09588335,0.034004506,-0.04451855,-0.0027718511,-6.852733e-33,0.081727326,-0.0870917,-0.0021621138,-0.10098207,0.023407541,0.016463047,-0.044639233,-0.051081266,-0.06230081,0.014814191,0.09793653,-0.015488819,0.050344076,-0.023575276,0.02552867,-0.09650316,0.026874352,0.060008384,0.034717962,0.044354416,0.06748027,-0.0358524,-0.06165293,0.025413437,0.04421874,0.010261816,-0.004396416,-0.008591464,0.06412217,0.004303168,0.021158943,0.02625704,-0.054990727,-0.034186386,-0.019326942,0.11032695,0.0027776835,0.07612967,0.06640607,0.05886721,-0.013172584,0.025584955,0.013994567,0.040363517,0.05255087,0.06499703,-0.1435779,-0.05457387,0.001089436,-0.06455784,0.09788756,0.0714119,-0.07467322,-0.026820827,0.00074590277,0.07761415,-0.00067816273,-0.021625955,-0.017810903,-0.03209253,-0.02996037,-0.027501257,0.03937667,0.022946961,0.015828494,0.061376862,-0.012231766,0.029148007,0.06443611,0.0071806107,0.0056994017,0.019382829,0.017136177,0.07377816,0.024944294,-0.007948592,0.0075394777,0.017845389,0.07202711,0.027153336,0.017166095,-0.03418611,0.048381705,-0.06461669,-0.00809416,-0.08856326,-0.06636004,0.11701553,0.058744833,-0.014913313,0.0073546176,0.043506503,-0.07799908,0.049944807,0.029590316,-4.142448e-08,0.0014124868,-0.051305808,0.064167984,0.04259821,0.020585451,0.015516453,0.058135495,-0.07473775,0.048915163,-0.08750296,0.022560753,0.0532945,-0.0226347,-0.0008878036,0.015362488,-0.0008950059,-0.032743134,-0.012432267,0.0070022475,0.030472523,-0.057436097,0.019777555,-0.015420759,0.017070092,0.02854036,-0.092524715,-0.005683121,-0.001878175,0.036621395,0.012346719,0.058435004,0.04907521,-0.06750758,0.023332587,0.0378529,-0.023927122,-0.014851769,-0.01864405,-0.077514015,-0.022805383,-0.0136002675,-0.040862404,-0.07403098,0.008816343,0.065435536,0.032344546,0.036298662,0.039949644,-0.033290196,0.004375065,-0.0013961669,0.018515728,0.02598498,-0.1019646,-0.1767948,0.026652534,0.044533033,-0.022472942,-0.06890541,-0.1341773,0.021155767,0.0047751884,0.18698435,0.01635537 +1.14.19.65,"A cytochrome P-450 (heme-thiolate) protein catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline by the oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine. cf. EC 1.14.19.73, (S)-nandinine synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-nandinine.",384,1.0,-0.087825,-0.027784457,-0.08196448,-0.016802296,0.067418344,0.10014811,-0.035192758,0.075057976,0.0064542512,-0.0021261298,-0.03339713,-0.0034096513,0.018613067,-0.018537272,-0.07612376,0.08443155,-0.13,0.05158341,-0.011136794,-0.023286184,-0.018043987,0.03470422,0.055011842,0.02743698,-0.012034264,0.01971658,0.034739386,0.06292596,-0.0034302664,0.028906941,0.0042348336,0.024028994,-0.007818514,-0.016398057,0.027895587,0.034922495,-0.01337726,-0.013980477,0.00015631356,0.029284062,0.043338798,0.019332826,-0.09312821,0.034796678,-0.05642945,-0.038192037,-0.02529586,-0.011564216,-0.04030431,-0.050413508,-0.064728945,-0.01809621,-0.08703664,0.023054557,-0.02264124,0.027298385,-0.0017871734,-0.05410118,-0.003677088,-0.009539639,0.04642095,-0.037874885,0.0055604037,-0.02074258,0.061331317,-0.058112953,-0.020227777,-0.03296389,-0.0065026013,-0.06584373,-0.037553605,-0.07665785,-0.021007149,0.048090037,-0.08188362,0.034150757,-0.001506826,-0.015431664,-0.008992595,-0.0042627077,-0.0010117802,-0.011565964,-0.08278182,0.09122265,0.07506752,0.021398844,-0.006933602,0.06314435,0.057056516,-0.00045988595,-0.015879862,0.024816444,-0.04206704,-0.016568512,-0.15694836,-0.024308512,0.053235896,0.07506171,-0.007008927,-0.0043489775,0.050015397,0.05948945,-0.034405082,-0.09668504,-0.011363063,0.04416197,0.00016543537,0.07329762,-0.014025036,0.0054390463,0.008312575,-0.076666325,0.034590617,0.0079346495,0.0073829303,0.097623706,-0.03561267,-0.035038333,0.012052768,0.00021231476,-0.032673445,0.0019585676,0.0171431,0.027032048,-0.058945537,-0.005746437,-0.0736353,4.3630574e-33,0.07629795,0.09830326,0.015639795,0.051652256,0.023693893,-0.0067093316,-0.12410798,0.0707263,-0.042103756,-0.020760031,-0.11178632,-0.007033738,0.028709816,-0.037810642,-0.018965308,-0.046645835,-0.12819879,-0.011188491,0.030661797,-0.022997994,-0.059385132,-0.028375193,-0.045838892,0.005665033,-0.0040032053,0.0036803193,0.01190306,-0.008793186,-0.0035495555,0.012916954,-0.043638773,-0.10455779,-0.025618918,-0.075287156,-0.05678669,-0.0038514957,0.004982536,-0.025098281,-0.032238092,0.065154,-0.054702863,-0.027206719,0.0074166856,-0.021330098,0.054769527,-0.03754041,-0.088369615,0.09126079,0.035872627,0.022575429,0.0052447766,-0.09029967,0.087930806,0.042259023,-0.10805166,0.028400123,-0.025852984,-0.058241583,0.020067768,0.078036875,0.06656365,0.022818897,-0.010180602,0.014611319,0.05022133,0.051907603,-0.019946327,-0.039121423,0.024695504,0.057119753,-0.077566795,0.03150399,0.099117905,0.040614,0.0025128773,-0.011925869,-0.03163772,0.06491607,0.08482069,0.055143032,0.03253659,0.012439278,-0.062892914,0.052244652,0.022643477,-0.029103005,-0.00034027616,-0.05142054,-0.03371928,0.07039634,0.0074974275,-0.14199354,0.005113803,-0.0062771407,-0.027333051,-3.902858e-33,0.048081066,-0.08478119,-0.0064606634,-0.08386764,0.010648515,0.0131623885,-0.005559698,-0.009914416,-0.025811406,-0.0052448898,0.12096391,-0.03207405,0.07870002,-0.06350873,-0.0082814265,-0.09259388,0.04360533,0.034506578,0.0016018377,0.019390415,0.04648006,0.013648233,-0.06425089,0.015267931,0.021233272,0.077771515,0.007607121,0.014768637,0.060402982,0.07822614,0.0145474365,-0.013413481,-0.063914716,-0.046568383,-0.0036463744,0.13147163,0.013497597,0.06893523,0.047256563,0.047421526,-0.026034791,0.030491626,0.024439976,0.06518419,0.0707725,0.072244495,-0.11323568,-0.016502718,0.0033381185,-0.069055244,0.07428175,0.053209633,-0.08480121,-0.007865721,0.0159203,0.065237984,-0.006694213,-0.03866458,-0.050006613,-0.03171425,0.0038713566,-0.022879858,0.015034652,0.002446646,-0.0046221144,0.060387157,-0.08805303,0.05970892,0.10785228,0.0025583436,-0.023799736,0.0027148551,0.039160907,0.06564305,-0.0021788746,-0.00826229,-0.022414751,-0.010049204,0.044694945,0.022821799,-0.013870643,-0.03083365,0.027590018,-0.04168406,-0.0021540371,-0.055121552,-0.05148423,0.08078374,0.07222004,-0.06483522,-0.005762276,0.033599768,-0.08673341,0.08048349,0.0065597347,-4.512851e-08,0.009596401,-0.0690931,0.06876266,0.028726848,0.02828189,0.029790433,0.051697955,-0.07252245,0.09738621,-0.06434642,0.012673137,0.05626659,-0.020303091,-0.014915694,0.021373106,0.03764568,-0.04639281,0.007448269,-0.0021635292,-0.008856178,-0.047891997,0.043305043,-0.049452692,-0.0013778624,0.006255163,-0.06457177,-0.036800213,0.019875094,0.035175305,0.015674945,0.062977634,0.01192918,-0.037325952,0.05919058,0.04093736,0.013819153,-0.024009287,-0.020869782,-0.033748854,-0.054472372,0.015075355,-0.029193126,-0.10157662,0.042828023,0.09745027,0.027061364,0.031035703,0.065996245,-0.029909547,0.008532395,0.0027596976,0.027130555,0.03450436,-0.09877639,-0.12258482,0.028777976,0.002597153,-0.048494875,-0.076314375,-0.10478844,0.0264421,0.035707958,0.22083429,0.023597656 +1.14.19.66,A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine.,384,1.0,-0.030055147,0.025821036,-0.0425804,-0.015813164,-0.006524591,0.11242557,0.015175424,0.09173047,0.061797902,0.024110038,0.054799255,-0.045305938,0.0044172993,-0.0064939004,-0.06420726,0.042285115,-0.016929528,0.027164094,0.005766411,-0.11603867,-0.043902934,0.087321095,0.03960372,0.04606181,0.02552208,-0.017613797,-0.032495312,0.051560003,-0.015949165,-0.015116981,0.00071165647,0.014715207,0.05754203,-0.003533176,-0.012098584,0.07020918,-0.06443225,-0.059606284,0.047524665,-0.004912045,0.04534923,0.004431722,-0.077353865,0.063909024,-0.01896887,0.017721342,0.00069422217,0.08863884,0.03445339,-0.023607315,0.02690547,-0.06414504,-0.07849512,0.059564285,0.023584597,0.016727647,0.01049657,0.080691114,-0.035101503,0.06510483,0.015101363,0.054186802,-0.0013376495,-0.0063241664,-0.031328317,0.026190823,-0.071948625,0.006204685,0.0633334,-0.065566614,0.008300207,-0.08594759,0.017399939,-0.00861948,-0.09354445,0.068730004,-0.04804133,0.012143365,-0.0022428748,-0.05148095,0.030989885,0.004126312,-0.032201026,0.04164419,0.04812578,0.030044282,0.011145389,0.061009195,-0.020618053,-0.06368012,0.084122255,0.0029835994,-0.045399103,-0.08244689,-0.06889146,0.08587274,0.020486299,-0.04001688,0.013511207,-0.04342005,0.074646324,0.012823312,-0.06237182,-0.10490743,-0.060280122,0.08732855,-0.045357246,-0.027001036,0.011856593,-0.049210656,-0.061262842,-0.04894095,0.020796357,-0.011790143,0.003436907,0.095944904,0.019339968,-0.0278802,-0.07191417,-0.059271358,-0.028729498,-0.037858784,0.022100057,-0.011334005,-0.050176147,0.045007918,-0.033489965,6.371952e-33,0.08645095,0.039636314,-0.026676944,0.074323185,-0.0050110295,-0.0030839834,-0.012765475,0.042999674,-0.07247237,-0.029960265,-0.07944118,-0.085257865,0.031723253,-0.011206376,-0.031705473,0.041288767,-0.096150644,0.025980068,0.075390324,-0.043155234,-0.13552175,0.01809882,-0.059223637,-0.039827865,-0.02023356,0.08283636,-0.04845966,-0.030047184,0.017543484,-0.0370902,-0.01517491,-0.07896731,-0.10260998,0.0017694565,-0.020642612,-0.052035633,0.015452623,0.0062525785,-0.059202593,0.06484634,0.02055356,0.039870482,0.04769254,-0.02987401,0.07175135,0.006386447,-0.08496676,0.062736236,0.06746988,0.06799992,0.054093026,-0.0077805514,0.105250694,0.028696196,-0.07492503,0.05213027,0.041180454,0.03331133,0.029152572,0.046958096,0.023854684,0.06408258,-0.05081815,-0.027341973,0.033939887,0.040775817,-0.09203805,-0.02822491,-0.004100288,0.12211548,-0.02202085,-0.056889754,0.04158293,-0.007888704,0.018934755,0.00047334805,-0.05267397,0.0027093007,0.003545147,0.012144146,0.027950445,0.013578206,-0.0008255613,0.010720651,-0.054128055,0.006471818,0.04717149,-0.06476533,-0.04882439,0.045411855,0.08662991,-0.004588963,-0.0085075,-0.01764094,-0.015517431,-5.282726e-33,0.071116,-0.050017122,-0.0020335268,-0.0598433,-0.02885503,0.016180437,-0.0070828437,-0.044491976,-0.00858515,0.008427266,0.10197319,-0.05017562,0.024304928,0.027337987,0.050841168,-0.038281996,0.001080799,0.116892904,0.0029537568,0.027700271,-0.015564596,0.02285013,0.015933713,0.03983908,0.01060257,0.04703765,0.018033713,-0.021848494,0.09312933,0.03756258,-0.05921369,-0.005942434,-0.069605336,-0.031272147,-0.0036472648,-0.0024961003,0.018646328,0.008156931,-0.033185974,0.034149714,-0.03188861,0.065164044,-0.0030879413,0.061816487,0.07061731,0.043789905,-0.07136241,0.018662872,-0.04725377,0.024180507,0.10906167,-0.026088685,-0.024476217,0.031212028,0.026304936,0.019902308,-0.022626456,-0.015808687,0.018152447,-0.04120612,-0.013171105,-0.07306802,-0.023768121,-0.010328083,0.008452567,0.10177849,-0.0038062928,0.07893401,0.00025688618,-0.01933561,0.05464114,-0.015112145,0.034030404,0.048202977,-0.07047673,0.0025764024,0.012023671,-0.03482939,0.037989806,0.024812175,0.022457942,0.04456604,-0.011271906,-0.08157925,0.0025385215,-0.076202594,-0.062364172,0.12720582,0.08736241,0.006529127,-0.04896317,0.053907145,-0.057879936,0.059972305,0.12472589,-4.3761485e-08,-0.0034104544,-0.07576331,0.024701348,-0.03476352,0.03963106,-0.0020083587,0.050763585,-0.003250041,0.05581777,0.024602095,0.014069876,0.013205843,-0.07217552,0.077326335,0.014014602,0.0067592193,-0.010844171,-0.012156062,-0.013616485,0.005732613,-0.0906313,0.06951033,-0.055293467,-0.05166711,0.01812169,-0.122306086,-0.012800482,0.018173922,0.030984558,0.006057401,0.018990956,0.03714971,-0.004918074,-0.05695124,0.019763146,0.020106379,-0.023179503,0.029612008,-0.020176584,-0.024483088,-0.0796363,-0.030762935,-0.06387779,-0.018699264,0.040123135,-0.0730493,0.054069474,0.039809022,-0.00056690926,0.01497208,-0.01893059,-0.03423849,0.062612005,-0.16643351,-0.15327944,-0.056998562,-0.01836448,-0.03473595,-0.02602476,-0.15119906,-0.04565824,-0.042262748,0.187546,-4.9266953e-05 +1.14.19.67,A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.,384,1.0,-0.018759882,0.013634838,-0.023384368,0.033960678,0.07778577,0.10989296,-0.0006432934,0.0930758,0.04752729,0.010509318,0.0637166,-0.010764486,0.0007498058,0.020271404,-0.032894272,0.06220505,-0.06943513,0.06825892,0.009125265,-0.055605832,0.038906712,0.09906401,0.024644636,0.011780761,0.028775316,-0.04316439,-0.02980614,0.07160178,-0.015656639,-0.09790899,0.004851037,-0.0026411554,0.008323711,-0.0058984216,0.016115353,0.071772896,-0.042754237,-0.08218528,0.016829627,0.010072094,0.043235417,0.016587185,-0.11222379,0.042864002,0.014538797,-0.024147447,-0.02618401,0.03213816,0.052827407,-0.04441508,0.0053161527,-0.051104914,-0.050395973,0.053503435,-0.032224327,-0.07759419,0.009997714,0.011579579,0.015047129,0.0006790757,-0.036745194,0.027727362,0.02112222,-0.072523735,-0.017376086,-0.064425774,-0.06178524,-0.033285048,0.046053633,-0.10034301,-0.0056603686,-0.11942837,-0.005359963,0.013038653,-0.06982549,0.047028307,-0.041310187,-0.01147054,-0.06545866,-0.043688845,0.06580628,0.010704388,-0.08386816,0.120362096,0.07082539,-0.030531108,-0.020774879,0.055454366,-0.021534566,-0.040924884,0.013693265,0.028408356,-0.023102,-0.027212316,-0.06845626,0.026720969,0.0016260998,-0.004772534,-0.029055346,-0.010239232,0.06618228,0.03177332,-0.082315765,-0.083580025,-0.03138723,0.0074968906,-0.031367566,0.018787846,-0.01621518,-0.10158514,-0.018490644,-0.014540084,0.010766492,-0.031064928,0.037371356,0.06250399,-0.00048766352,-0.0430617,-0.08506734,-0.0627711,-0.07415416,-0.0219815,0.029090771,-0.008022549,-0.028487014,0.03530822,-0.07523331,4.5003103e-33,0.064221635,0.042316183,-0.036117397,0.07777844,-0.037445895,-0.044548508,-0.019800691,0.05548801,0.016333155,-0.08337919,-0.09614959,-0.045151092,0.0043516317,-0.008360907,-0.014514194,-0.027271114,-0.041959375,-0.0003938366,0.069850005,-0.030560035,-0.13645294,0.012215342,-0.028846476,-0.024426464,-0.0024598571,0.05645464,-0.029843362,-0.045330472,0.006302078,-0.021449484,0.015740272,-0.013433768,-0.040212765,0.013395548,0.06340082,-0.03606851,0.03409773,-0.022234255,-0.05542705,0.046651248,-0.019940186,0.03315231,0.03845561,-0.0155950785,0.07186398,0.0074252808,-0.14868808,0.0974249,0.0064035133,0.061788253,0.027584972,-0.0068238797,0.13198744,0.04279765,-0.08971538,0.012691089,-0.008713097,0.015446409,0.031352907,0.061064955,0.0602356,0.08500532,-0.092902385,0.051440895,0.023757232,0.030563302,-0.048447985,-0.014832857,0.022612209,0.13374831,-0.029148431,-0.013269447,0.016920177,0.0112317195,0.029735947,-0.030117763,-0.07125955,0.11531306,0.027448604,0.04116489,0.048534628,-0.02304386,-0.057347693,0.007809779,-0.011448708,-0.0019661903,0.08707527,-0.016419634,-0.012096588,0.05420687,0.0626173,-0.012505849,0.016760124,0.006387114,-0.022757385,-3.431049e-33,0.10113912,-0.08066953,0.014886459,-0.051152464,-0.0262385,0.01077412,-0.047332577,0.026064968,-0.0360801,0.017890595,0.09971442,-0.04872759,0.041708753,0.0052126804,0.038051892,-0.0375529,-0.04656377,0.07195904,-0.0108740125,0.058428317,-0.104522884,0.03013226,0.01533345,0.04792787,0.04313656,0.06771247,-0.027923895,0.004696676,0.037375916,-0.03869017,-0.015364714,0.05192358,-0.064058386,-0.07433514,-0.024554316,0.02602338,0.013087635,-0.02168553,0.003725268,0.04935569,-0.01766749,0.086082034,0.014774893,0.03350616,0.0874709,0.0639639,-0.04630424,-0.018195478,-0.037895724,-0.05051869,0.086201094,-0.011815024,-0.012639123,-0.029536407,-0.012100539,-0.00521744,-0.049986776,0.022983775,0.029220233,-0.02997306,0.020163516,-0.051978443,-0.024989458,0.044776984,-0.03037017,0.063891634,0.05793043,0.03267534,0.06227434,-0.020655598,-0.015428156,0.009921077,0.087568484,0.032454733,-0.03373202,0.022410553,-0.0012935082,0.011295427,0.04292754,-0.019911252,0.017689953,0.014705981,-0.031596974,-0.06442612,0.040575363,-0.061182696,-0.10124983,0.08257771,0.05003227,-0.037818164,-0.029323267,0.010575106,-0.04723445,0.10939316,0.099062026,-3.525194e-08,0.030221518,-0.04792757,0.06946237,-0.015324606,0.022854103,-0.022727888,0.06614558,-0.0077489074,0.03652368,-0.0142151965,0.017094491,0.057757813,-0.030152092,-0.010970256,0.031355638,0.012419616,0.025730139,0.08924195,0.041383922,0.049098793,-0.039050512,0.032685757,-0.03429596,0.066442095,0.031222079,-0.09704243,0.007259598,-0.057866957,0.04761647,0.012098389,0.08939115,0.0097005945,0.00870181,-0.025901794,0.026131274,0.014639661,-0.024307484,-0.043672886,0.007606375,-0.019196996,-0.0214437,-0.030656386,-0.07741983,-0.041240625,0.029110773,-0.063931026,0.024219727,0.023498623,-0.040027402,-0.025653847,0.013256564,-0.037539534,0.016578693,-0.14725295,-0.14592335,-0.057464134,0.058598742,-0.073251195,-0.052777804,-0.15546386,0.013134899,0.034796737,0.1862383,0.022651125 +1.14.19.68,A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme catalyses an oxidative reaction that does not incorporate oxygen into the product. Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine.,384,1.0,-0.06819091,0.03853391,-0.07191951,-0.017524812,0.06746163,0.07206144,-0.04976077,0.07305482,0.06601095,0.038406882,0.048917063,0.008601406,-0.009110427,-0.017595148,-0.06523244,0.08038638,-0.091044895,0.040547904,-0.0055594346,-0.064846,0.027651688,0.07136193,0.033686217,0.0012814706,0.016722672,0.011789016,-0.027607113,0.07098547,0.007697523,-0.051696125,-0.061634116,0.0577422,0.0015139898,0.015846267,-0.01589247,0.1007925,-0.04687358,-0.10619997,0.017729796,-0.017166633,0.028913956,-0.031127684,-0.096068196,0.021493739,-0.070127204,-0.0536862,-0.020734923,0.018912556,0.0023096013,-0.05171296,-0.001274223,-0.0074223564,-0.015590758,-0.012339305,-0.029056387,-0.013209825,0.025219863,0.056516606,-0.0404082,0.01912699,0.035348725,0.012835197,-0.023353847,-0.004121488,0.014690063,-0.057238184,-0.070042215,-0.0064019267,-0.024468075,-0.098200925,-0.010028975,-0.0856408,1.3974471e-06,0.0130464295,-0.06838088,0.060143944,-0.027273742,0.014590917,-0.0012604754,-0.016416607,0.01923562,0.025162399,-0.08106992,0.10829962,0.06347405,0.009067394,-0.048687626,0.09028331,-0.014305815,-0.03541805,0.0010433462,0.029163545,-0.033640504,-0.005207972,-0.07454685,0.07461758,0.095360346,0.016428921,-0.021614237,-0.019594382,0.042975396,0.058163483,-0.067274645,-0.07887084,-0.060320154,0.0106881205,-0.03653851,0.018017506,0.04418627,-0.040086936,-0.04408204,-0.063236274,0.03892822,0.0075201695,0.0072808973,0.09502119,0.009851767,-0.052251115,-0.058179572,-0.081016414,-0.06727071,-0.026782217,0.004822179,0.019963415,-0.0600303,0.051329087,-0.05096199,5.34964e-33,0.107312396,0.0780816,-0.030388273,0.022895575,0.0041894037,-0.004168509,-0.044197537,0.06461091,0.0050773323,-0.032534227,-0.108841375,-0.022554636,0.028409742,-0.07038065,0.00713033,-0.041420236,-0.07406346,0.011050274,0.07304481,0.01081325,-0.09655001,-0.007165171,-0.06101287,0.017231567,-0.056806784,0.066787995,-0.0013500296,-0.084955975,0.020937912,-0.0083114095,-0.035175074,-0.07330926,-0.06797475,-0.03487879,-0.039662585,-0.025842123,-0.012943118,-0.007068316,-0.073710196,0.057131734,9.28045e-05,-0.019952001,0.047857523,-0.062308248,0.02873898,-0.015435358,-0.105310045,0.077251546,0.020283964,0.057157148,0.03957036,0.00028721304,0.11405515,0.009996747,-0.07551701,0.031922348,-0.0024129795,0.019983353,0.0046605696,0.087748736,0.03627111,0.040904004,-0.02041785,0.06531513,0.004767962,0.030995177,-0.062301867,-0.049602225,0.008935818,0.13977301,-0.04980554,0.007002774,0.046784237,0.009099311,0.0045487797,0.013270099,-0.02914321,0.0785132,0.06870439,0.026418922,0.05625268,-0.01772771,-0.029528394,0.016350282,-0.0013371038,0.008009946,0.029868212,-0.049134795,-0.0369736,0.071659744,0.04334294,-0.080497935,0.028285118,-0.040734403,-0.0018458976,-4.5833704e-33,0.097667255,-0.06936573,0.004534393,-0.118077986,0.0128569845,0.016739726,-0.06275129,-0.057715416,-0.032668807,0.009308353,0.1107963,-0.02689381,0.040785752,-0.01593469,0.02817671,-0.05787831,-0.008625822,0.08066813,-0.012866931,0.05607824,-0.020808266,0.036432803,-0.003257893,0.027469197,0.01205722,0.05863068,0.00393575,-0.0287969,0.045821674,-0.008058399,0.014389306,0.0011559778,-0.057184957,0.010933132,0.029688967,0.07871579,0.011489302,-0.008495063,0.042234946,0.04992152,-0.039231088,0.06685046,0.03238327,0.045669932,0.059959345,0.03811106,-0.11928475,-0.085843995,-0.019580292,0.0037677593,0.10381983,0.06339746,-0.055987123,0.01219562,0.015827296,0.02721747,-0.019189345,0.011380008,-0.030333092,-0.0453166,-0.015245833,-0.013442302,-0.011542719,0.068754606,-0.0008771846,0.048677858,-0.06990401,0.06759734,0.01690159,0.009977622,0.029691977,0.014584785,0.059585858,0.079438396,0.021936936,-0.005349983,0.03215101,-0.024369411,0.031114804,-0.038139578,-0.046510816,0.033436205,-0.011819168,-0.08819417,-0.013838188,-0.074563645,-0.07793438,0.12015816,0.05803236,-0.012603975,-0.008335956,0.04323477,-0.089732155,0.09228056,0.12112761,-4.2198224e-08,-0.032336045,-0.08122406,0.042394564,0.010466605,0.04345764,0.020189986,0.08135747,-0.010173436,0.07093274,-0.03886216,0.016057631,0.059442118,-0.057625182,0.022152815,0.011882537,-0.006170774,0.0017079959,0.0006719422,0.012552298,0.019371238,-0.06810867,0.026468864,-0.029856393,0.022731546,0.00768946,-0.08811557,-0.043596916,-0.036988698,0.07506967,0.011750912,0.053357262,0.04038344,-0.032664694,-0.0018865744,0.013655975,0.013375219,0.028038586,-0.008087802,-0.030244615,-0.020613506,-0.047339603,-0.021431586,-0.08445042,-0.0043515284,0.043836463,-0.0145039195,0.0037840018,0.04641785,0.0042193127,0.00528254,-0.02215911,0.014232286,0.053100344,-0.14560375,-0.13604626,-0.01719086,0.04439223,-0.008114123,-0.026040742,-0.11704024,-0.00094071636,0.018097267,0.23043932,0.009318313 +1.14.19.69,"This cytochrome-P-450 (heme-thiolate) enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product [1,3]. The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation [1].",384,0.99999994,-0.054774422,-0.009838968,-0.09303467,0.015942026,0.07496134,0.0381317,-0.009639685,0.103229664,0.036296465,-0.028335,-0.006770967,-0.0811182,-0.029383443,0.052188095,-0.043571975,0.056750603,-0.072338216,0.03419076,0.019059518,-0.07818797,-0.02115958,0.029531991,-0.011476253,0.0155963395,0.013336216,0.002532605,0.016899226,0.025473239,-0.036491852,-0.05327327,0.029061979,-0.0035187788,0.08290546,-0.0372701,0.04407993,0.09740564,-0.057149746,-0.15834233,0.038784776,0.016414698,-0.030933028,-0.004807129,-0.014349538,0.042846017,-0.07793245,-0.01573387,0.025133714,0.10076842,0.04665569,-0.05247381,-0.02852381,-0.026992047,-0.08386886,0.001414683,-0.021293363,0.11116687,0.011801541,-0.011117177,-0.010802706,-0.012290125,0.035498828,0.003739032,0.013478122,0.046946578,-0.06752707,0.025670033,0.0099630775,-0.09876292,0.04202736,-0.030112104,-0.09415582,-0.07140192,0.00039699895,0.009569897,-0.025976334,0.07903446,0.0005774089,0.0072096735,-0.024505572,-0.050176553,0.067110166,-0.026865706,-0.032457195,0.113971286,0.06662977,-0.056707628,-0.036508683,0.017419875,0.0242703,0.04125613,0.012932832,0.07866814,-0.026692532,-0.062175296,-0.1579653,0.062324148,0.0237298,0.0314702,0.020147989,-0.03987782,-0.0109108025,-0.0057030832,0.044785243,-0.060972743,-0.006499443,-0.07085673,-0.013193113,0.04708308,0.054745212,-0.038890444,-0.006022818,-0.010924818,0.0032873591,-0.07441475,-0.01528355,0.099500544,0.06255242,-0.07058202,-0.048242852,0.03447999,0.013157185,-0.012037611,0.0005051779,-0.014034087,-0.0044326927,-0.08367477,-0.031645343,3.462731e-33,0.04870331,0.06905185,-0.024193458,0.00066719344,0.027284667,0.011554753,-0.05620497,-0.0017358299,-0.11213222,-0.028486744,-0.08053618,-0.0054245046,0.021825956,0.009820297,0.009864813,0.03926547,-0.026073929,0.022329893,0.020251986,0.02549856,0.021511398,0.016730586,-0.020681733,0.021940887,0.020828694,0.048952844,0.0076175183,0.011369472,0.044738814,-0.008374708,0.014620297,-0.05039743,-0.0693317,-0.028936269,-0.0022507263,-0.028438985,-0.102393575,-0.061586194,-0.040808342,0.108796954,-0.09300333,0.060416542,0.06849248,-0.0349315,0.07833316,-0.039347097,-0.07775374,0.060938384,0.04024679,0.0710772,0.021566886,-0.07002393,0.093378715,0.02907349,-0.06001868,0.03743128,0.020605626,0.037953477,0.0030214228,0.019427719,0.06347448,0.07981419,-0.027044624,0.033194765,0.035031527,0.015539531,0.02466607,0.035344236,0.010997609,0.07894013,-0.043531075,0.013235712,0.037359577,-0.043547697,0.008154831,0.003229983,-0.06464984,-0.034704145,0.075279064,0.025450638,-0.037402336,-0.013122766,0.010305348,-0.07554922,-0.034833286,0.035581935,-0.010043701,0.06634249,-0.034693,0.080255106,0.044538938,-0.11298842,-0.0031969391,-0.044173855,-0.012323029,-3.2842063e-33,0.099925935,-0.06573811,0.017771082,-0.07495188,-0.05132237,0.015067583,-0.07761863,0.0065222727,-0.031350236,0.0017294185,0.12786151,0.012909246,-0.0024403972,-0.016888276,-0.02185499,-0.02443681,0.023846807,0.060991686,-0.039258312,0.019959481,-0.016569532,0.009659836,0.046089586,-0.002869258,-0.052084956,0.029243907,0.037424944,-0.029423172,0.07788237,0.074336655,-0.046861585,0.021564178,-0.029989105,-0.06816513,0.046127234,0.026396431,-0.0017280156,0.00469683,0.06486945,-1.1822896e-05,0.05303258,0.011549025,-0.011690921,0.017074345,0.024453338,0.09306323,-0.097195044,-0.033902094,0.009212805,-0.03193221,-0.013881563,0.020021018,-0.08812012,0.010849902,-0.044000916,-0.00059479143,0.030426916,0.016169136,-0.009508829,-0.024546249,-0.02403514,-0.053954456,0.03997346,0.012845401,0.047690786,0.12728469,-0.06307204,0.15288965,0.04990926,-0.024736285,0.03805491,-0.0004397806,0.013304931,0.100469,-0.023905925,-0.0024261407,0.017194452,0.022448333,0.029547848,0.031008676,0.046253823,-0.03939177,-0.01867504,-0.046435077,0.01948407,-0.16104718,-0.062046736,0.029984139,0.0120652625,-0.031599946,-0.019180676,0.059254326,-0.002737796,0.013885189,0.05948768,-4.3759968e-08,-0.020659564,-0.017935216,0.05009254,0.0059916237,0.07811006,0.02345946,0.024777833,-0.02913602,0.01848234,-0.02277131,-0.07551833,0.062285192,0.012345458,-0.0037797422,0.026896719,0.0934814,-0.084730886,-0.08013276,0.02309961,0.0033116553,-0.0987765,-0.005014457,-0.08848101,0.042713944,0.019556466,-0.007961758,0.0071489704,-0.0035465553,0.046894614,0.047985643,0.040005244,0.042077314,-0.06037128,0.06817495,-0.049019687,-0.053259864,-0.047216877,-0.07261597,-0.0524145,0.017077805,-0.039958116,0.008005211,-0.112761624,0.014210819,0.010472897,-0.0016537099,0.04467629,0.019950004,-0.055195887,-0.0022835087,0.044607583,-0.06237053,0.0022305867,0.0028214362,-0.11132601,-0.04827169,0.10333969,-0.04226753,-0.041735947,-0.06369202,-0.018395586,-0.060698505,0.19141546,0.01281256 +1.14.19.70,A cytochrome P-450 (heme-thiolate) protein from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product.,384,1.0,-0.09561784,0.031872746,-0.030411283,0.005263461,0.052461043,0.024272334,0.035591945,0.12271945,-0.02469321,0.024177812,-0.05163922,-0.008372996,0.072951026,0.021953689,-0.022203168,0.06359459,-0.02193648,-0.008334666,-0.006542069,-0.0642114,-0.005610481,0.108865775,0.051359233,-0.00785303,-0.004927505,0.021482613,0.0720719,0.054136854,-0.043475725,-0.051183466,-0.012567356,-0.062854126,0.05684903,-0.073673986,0.05173793,0.0671082,-0.031414744,-0.10062142,0.049613245,-0.038640995,0.039446134,-0.011133503,-0.06490998,0.058917984,0.0015639943,0.0039258935,0.005556892,0.046328504,0.022203859,-0.008693172,-0.036089752,-0.009430136,-0.10438321,0.013903253,0.016628938,-0.010759421,-0.0047501083,-0.039500598,0.022967776,-0.041230828,-0.001279868,0.016087798,0.030246936,0.042007204,0.011762754,-0.03425723,-0.037264287,-0.015230484,-0.04003785,-0.051179927,-0.051042594,-0.06744923,-0.05908854,0.059455972,-0.087512165,0.0039425925,-0.004351457,-0.05483452,0.0013563171,0.06954636,-0.030232696,-0.047108464,-0.04942563,0.08086274,0.05369092,-0.021336459,0.039532036,0.018057596,-0.019317834,-0.003545826,-0.02968189,-0.006141576,0.021189254,-0.023378514,-0.1033155,-0.022343123,0.07783291,0.039386,0.00703459,0.006452219,0.034000978,0.04760615,-0.0019718893,-0.08267775,-0.060936622,-0.017765928,-0.030147603,0.083025396,0.09741502,-0.05931525,-0.031410024,-0.041762747,0.008243708,-0.03441374,-0.0022361516,0.08746201,0.0661208,-0.027138432,-0.079369545,-0.006985687,-0.0106253,-0.051142883,0.0010477146,-0.0153885465,-0.11365889,-0.0148443645,-0.08011197,2.1013984e-33,0.041975252,-0.036934003,0.031800404,0.03336347,0.00061985425,0.003459445,-0.091961764,0.007582703,-0.0012431417,0.01560375,-0.106241226,-0.060388923,0.032774236,-0.0044369884,-0.06439395,0.03700473,-0.062738106,0.040630307,0.051825676,0.05604735,-0.03507281,-0.029977284,0.020466141,0.026969833,0.039909385,0.08043201,-0.015414425,-0.050248962,0.009244887,0.007090794,-0.027443953,-0.049765516,-0.089958034,-0.10555025,-0.031165475,-0.06304494,-0.03800641,-0.028707735,-0.0027363598,0.03703662,-0.031682476,-0.010423528,0.0033962152,-0.048055686,0.0753245,0.01984258,-0.05469765,0.049617305,-0.028253248,0.03690292,0.04629754,-0.08595765,0.08204171,0.008674826,-0.020137891,-0.012331296,-0.011803292,0.0933353,0.036413085,0.046865795,0.11478507,0.105474,-0.037942234,0.09588858,-0.009841445,0.022141991,-0.018250857,-0.008785598,0.03453138,0.070498556,-0.01515736,0.04412899,0.0473563,-0.07908539,0.05215638,-0.03305734,-0.061200406,0.020727316,0.06609889,-2.9054354e-05,0.07087819,-0.014829767,-0.037266284,-0.06897665,0.035833452,-0.023905555,-0.022744788,0.003981535,-0.054016832,0.015077171,0.05427489,-0.09008185,-0.008746619,-0.017371554,-0.08490557,-2.8295424e-33,0.083648965,-0.11928928,0.035942607,-0.09448822,0.017322483,-0.02108125,-0.0020343612,-0.038926486,-0.018226082,-0.0037588782,0.08274158,-0.045293123,0.033712257,0.0059489002,0.0016685935,-0.031512164,-0.021789964,0.021581408,-0.04107948,0.034221955,0.01884732,-0.017393196,0.02755751,-0.07415593,-0.0033420501,0.084209256,-0.058892787,-0.021485552,0.13228956,0.058019705,-0.07473573,0.061025027,-0.016941193,-0.07817256,-0.071043745,0.038122743,0.007384212,-0.027163835,0.079093985,-0.0047897324,0.008838514,0.09179811,0.0055925013,0.037066717,0.026801895,0.06272187,-0.08743556,-0.061487623,-0.0066736285,-0.024575306,0.070674635,0.0014778507,-0.05275523,-0.022295427,-0.035649706,0.0124582155,-0.035529383,-0.0073186806,0.044377767,-0.05885112,-0.048011143,-0.04239311,0.026632994,0.04241361,-0.0040641874,0.14353532,0.0015667918,0.09523601,0.049317904,-0.031074228,0.037792817,-0.0133665595,0.04462092,0.04413752,0.07080437,0.02670794,0.009159158,0.033804055,0.0595319,0.0562198,-0.057792574,-0.007444025,-0.047867514,-0.070295654,0.01465131,-0.09099741,-0.07189868,0.0937901,-0.0041115703,-0.010440278,-0.040075924,0.08288504,-0.01981448,0.08863849,0.07084304,-2.8305688e-08,-0.009909275,-0.05886971,0.08192262,0.025987249,0.07628766,0.04509452,0.031149121,0.0022523436,0.09514014,-0.03402492,0.07066648,0.073217385,-0.0042880294,-0.04730313,0.053564347,0.03735077,-0.03485041,-0.07001724,0.031422086,-0.02776979,-0.025024481,0.026034664,0.01836413,0.074433185,0.012470873,-0.10122514,-0.006894419,-0.037600305,0.018370455,-0.031839382,-0.028607905,0.07943725,-0.069399804,-0.036020014,-0.04005667,-0.06892669,-0.012835856,-0.032488428,0.0011165511,-0.009470171,-0.03423988,-0.030013703,-0.10410715,-0.0034639887,0.032667108,0.025538374,0.031412177,0.038772684,-0.075554684,-0.04715738,0.0033745756,-0.014734128,-0.0031685422,-0.04034968,-0.09569433,0.053015746,0.05309172,-0.0021789076,-0.07633565,-0.08656518,0.020917786,0.016410269,0.18584171,0.0006182695 +1.14.19.71,A cytochrome P-450 (heme-thiolate) protein. The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.,384,1.0,-0.012566065,0.030845763,-0.07668135,0.00091903505,0.010403203,0.08676365,-0.045223754,0.084928915,0.03589256,-0.004847763,0.03381521,-0.0989928,-0.012741311,0.103296444,-0.07940812,0.034992006,-0.0019589548,0.050133344,0.00866341,-0.08649736,-0.040490612,0.09463394,0.095286176,-0.0035818487,-0.017894363,0.010691944,-0.01140857,0.068615854,-0.024490358,-0.061904036,-0.05286021,-0.026011882,-0.043897487,-0.024487613,0.005047232,0.08735705,-0.13266538,0.029730013,0.10726245,-0.0048914487,-0.042745784,-0.06478861,-0.09237353,0.025179261,-0.090860546,-0.00046210404,-0.015099908,0.020492258,0.08668825,0.0055546053,-0.01256129,0.02259147,0.025127478,0.036974654,0.094412126,0.015305352,0.03459634,0.010467982,-0.032750044,0.023638094,-0.02770928,0.036891636,-0.022212299,-0.017254036,-0.030957501,-0.010867995,-0.042069428,0.006561585,-0.04264373,-0.04701165,0.013948475,-0.06993313,0.0058931354,0.0027934024,-0.006624579,0.12496078,-0.038283963,-0.028731538,-0.062332075,-0.07023519,0.10065048,0.009249741,0.0131558245,0.08319783,-0.02208787,-0.04787389,-0.00979102,0.036732435,-0.01698779,-0.0061226324,0.07098201,0.06414331,0.0079816915,-0.042866714,-0.0101228375,0.030217143,0.021074772,0.049249854,-0.018013412,-0.0439561,0.050618757,-0.018429635,-0.021184742,-0.059488975,0.0118232975,-0.051661033,-0.024991456,0.028143216,0.12578885,-0.07042431,-0.005038918,-0.043489512,0.08418648,-0.048250422,-0.0045669684,0.02943197,-0.0037510784,0.012527268,-0.029706914,-0.04130307,-0.00707794,0.034872547,0.009523981,0.026447522,-0.029688891,-0.017102133,-0.06325307,4.5744006e-33,0.113120496,0.04318432,-0.07113568,0.0782669,0.029327568,-0.051020112,-0.04015539,-0.0031636208,-0.0108748395,-0.009378094,-0.11760031,-0.049450267,-0.048285477,0.020064626,-0.0055615655,0.00206704,-0.054437708,-0.048886295,0.012231461,-0.012688602,-0.027952934,-0.015877882,-0.04624598,-0.036910884,-0.010894401,0.09056357,0.022247529,0.041112076,-0.0017644262,-0.035565794,-0.06295776,-0.043798123,-0.08727121,-0.04990459,0.049590405,-0.030745316,0.028155688,0.02426112,-0.117139034,-0.03083772,-0.008776636,0.0674136,-0.04691976,-0.08181504,0.060702242,0.0063879513,-0.09602566,0.08811149,0.050581213,0.09257992,0.12249536,-0.07087954,0.087505445,0.04988614,-0.04283472,0.002429265,0.0035853428,0.016584696,0.008539063,0.081170194,-0.0044285925,-0.0055082613,-0.044542838,0.043006588,0.019258212,-0.0065994426,-0.018776998,-0.0869777,-0.018599529,0.07342516,-0.04247112,0.032713305,0.016692694,-0.04149075,-0.015828356,-0.0076873023,-0.038028214,-0.010537688,0.018928917,0.030077565,0.03667809,-0.040580302,-0.004728966,-0.015172091,-0.03621819,-0.051769223,0.021223675,-0.03471865,-0.007366208,-0.009299076,-0.023139745,-0.09629815,-0.026667595,0.093869366,0.010344578,-5.7935095e-33,0.073853046,-0.09674788,0.05972607,-0.052205518,-0.06096486,0.08600501,0.038594075,0.014815961,-0.02149231,0.009657733,0.12423168,-0.047197066,0.079833165,0.06340857,-0.039494995,-0.060063522,-0.024924835,0.08353555,0.0003698684,0.08573263,-0.040407583,0.03345636,-0.027485903,0.05870744,0.072176166,0.08695822,0.012824654,0.02383663,-0.062809624,0.0075388243,0.043923046,0.05011746,-0.112135984,-0.036034584,-0.0053872904,0.049339987,0.040612467,-0.005096355,0.013211783,0.030146934,0.0058305496,0.08268011,0.028005486,0.05815305,0.0053406567,0.058894236,-0.07941811,-0.016352253,0.011026074,-0.09470544,0.013030488,0.0041608457,-0.029360091,-0.0010566036,-0.029375546,-0.02982318,0.007959329,-0.020341178,0.056609094,-0.033852164,-0.075826764,-0.04491146,0.0045173583,0.025026005,-0.03982293,0.07482441,-0.043788653,-0.044879492,0.12449334,-0.03290389,0.047251325,-0.0004401706,0.07469735,0.085805155,-0.018880267,-0.050674185,0.02004123,-0.002217511,0.075288795,0.061203595,0.030902136,0.013509506,-0.0047449707,-0.040446296,-0.01098437,-0.05624135,-0.026238194,0.087098055,-0.012118232,-0.050629288,0.0019617358,0.070927024,-0.01991782,0.065815516,0.056453813,-3.5536306e-08,0.018384628,-0.04068163,0.03927516,-0.047802944,-0.0011404032,-0.014708493,0.05144735,0.00011454575,0.014959277,-0.07027906,-0.035697963,0.07025821,-0.103681564,0.04702863,0.019052947,0.00810346,-0.001499141,0.052574903,0.045707922,-0.009557534,-0.040400073,0.014349168,-0.029680952,-0.0077156923,0.007597739,-0.0829918,0.032972317,-0.028840842,0.05799965,-0.013598297,0.008014817,0.0145105,-0.03561622,-0.040869474,-0.0019418695,0.022191143,-0.021933516,-0.019026434,-0.026451537,-0.014465213,-0.0034883698,-0.066430904,-0.095101625,-0.06530244,-0.073666416,-0.06633301,0.015334906,0.079818904,0.009441911,-0.043266423,0.022232892,-0.024460893,-0.0012696452,-0.07363072,-0.12572336,-0.05245752,0.05622039,0.001213879,-0.065785915,-0.1342026,-0.012436411,-0.018715626,0.15823044,-0.02998465 +1.14.19.72,"A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plants Sinopodophyllum hexandrum and Podophyllum peltatum catalyses the formation of a methylenedioxy-bridge. It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.",384,0.99999994,-0.05606664,0.04568556,-0.025571793,-0.009055542,0.025377821,0.103048876,-0.014015207,0.08048236,0.036065906,0.028152276,0.008437878,-0.029722119,-0.041110955,0.0047792997,-0.055855412,0.1115282,-0.10238719,0.034119383,0.012610817,0.0018057865,-0.019866085,0.043561775,0.01133225,0.036493205,-0.012848519,0.0035402146,-0.0069230488,0.06835908,-0.0026490802,-0.05079889,-0.08413823,0.054084826,0.023199499,-0.01423898,0.05353664,0.11545355,-0.039866593,-0.0661049,-0.0036750985,-0.05782724,0.09106547,-0.044839006,-0.05214291,0.033139277,-0.041436892,-0.020446874,-0.009910451,-0.00678534,0.004538262,-0.017840203,0.006218774,-0.058059312,-0.04599565,0.035798114,-0.007367167,-0.0074892784,0.023806611,0.045573357,0.0099789025,-0.026213568,0.020482896,0.0337359,-0.02552444,0.038820643,0.013462369,-0.07057663,-0.023773605,0.013821518,-0.04307135,-0.019684045,-0.0062163942,-0.08512886,-0.004071901,0.03584874,-0.03596235,0.04126627,-0.0470913,0.020935208,-0.0074171643,0.0075004757,0.03659695,0.070453934,0.004799072,0.15149254,0.04835456,-0.00080610375,-0.01397244,0.049992494,-0.030241802,-0.062874414,0.012460719,0.03906607,-0.039531186,-0.0059424345,-0.09132037,0.060515232,0.02757471,-0.019215887,0.016854426,-0.0032131388,0.07466371,0.07248713,-0.06354151,-0.13549744,0.008002563,0.0065769013,-0.042643726,0.07592856,0.032070495,-0.036055546,-0.055041377,-0.06181445,0.00642764,-0.010411956,-0.03596873,0.09022311,0.009560677,-0.02924053,0.00042880495,-0.03277162,-0.046175495,-0.033745024,0.0039039087,0.04587559,-0.10662812,-0.011133644,-0.1119388,3.2405437e-33,0.121227145,0.024925152,-0.001959906,-0.02070512,0.04368692,-0.010856392,-0.046327703,-0.010166976,-0.0820267,-0.009447892,-0.13557795,-0.05533957,0.020590419,-0.022700537,-0.015390827,-0.023066659,-0.11524766,0.04586892,0.041482437,-0.033514027,-0.02303645,-0.018949429,-0.07129631,-0.009547024,-0.029953115,0.1172748,0.02739551,-0.0642356,0.035605773,-0.0042809234,-0.05783457,-0.060794394,-0.061797462,-0.04913905,-0.021857772,-0.024639139,-0.032005988,-0.028684994,-0.071431704,0.06886371,-0.030178584,-0.040971212,0.025344612,-0.08720636,0.06948216,-0.05693883,-0.11791025,0.015896093,0.015620697,0.07712612,0.050604995,-0.050850518,0.053835608,0.049569953,-0.107991606,0.019961666,-0.036354464,0.034895025,-0.057708133,0.042958844,0.060332593,0.008169754,-0.02574583,0.05353329,0.04172445,0.06438003,-0.032515533,-0.041439135,-0.025507595,0.087893836,-0.071858965,-0.026095262,0.051455952,0.013794212,0.03272795,-0.011819987,-0.024796456,0.0731905,0.03861078,0.086816154,-0.006991514,-0.015990585,-0.008387397,-0.0021848448,-0.005045335,-0.051220335,0.05081874,-0.043069772,-0.048203565,0.050301846,0.03076457,-0.09961823,-0.02474872,0.028755372,-0.052389607,-4.318086e-33,0.0782714,-0.036155056,0.059741817,-0.12012705,-0.027666053,0.04620513,-0.009766738,-0.034867126,0.0004891144,0.049733143,0.1006379,-0.0015181194,0.048923515,0.003823256,-0.0044890717,-0.034697685,0.013304305,0.028806685,-0.030783338,0.06639434,-0.028927464,0.015285354,-0.024265977,0.05934471,0.0063310093,0.024401758,0.046017293,-0.0032706663,0.05827122,0.032745525,-0.0348186,0.040090032,-0.08546441,0.008272549,-0.014244473,0.04571754,-0.03117149,0.014141243,0.062812984,0.031599227,0.0034605043,0.029964438,0.01816011,0.03890018,0.055521734,0.058898572,-0.097389966,-0.009317789,-0.0003427825,-0.004061066,0.039913718,0.08199524,-0.005247756,0.05116678,-0.012815586,-0.0125448145,-0.037769523,0.022191405,-0.042494673,-0.01950467,-0.017770939,-0.030316003,-0.006215828,0.07898534,-0.015297078,0.1118303,-0.07483305,0.0029698212,-0.015310468,0.0057675354,0.043469626,0.04598061,0.044256397,0.089117765,0.0023420954,-0.044119623,0.036984783,-0.03893832,0.037992056,-0.0027776118,0.033746306,0.04067631,0.006892946,-0.08096921,-0.021648733,-0.081432015,-0.023613965,0.1219178,0.03309141,-0.021042194,0.016442958,0.05512772,-0.09248728,0.0572048,0.053872503,-4.174119e-08,0.017076438,-0.06812177,0.007974604,-0.0561041,-0.030478671,0.021688912,0.04480189,0.0071329256,0.04231888,-0.048812952,0.015518436,0.04340861,-0.046443913,-0.022063935,0.005461044,0.019630708,0.00951218,0.0146401785,0.016556863,0.0060159643,-0.07650094,0.014215519,-0.010721927,0.03802745,0.013323039,-0.07431165,0.0049616876,-0.020907907,0.037989445,-0.021906868,0.038481236,0.07946484,-0.080952294,0.026391989,-0.0185159,0.09690917,-0.008705732,-0.07437351,-0.03493431,-0.006325151,-0.014885492,-0.019130945,-0.075588934,-0.046836674,0.04468757,0.0013731637,0.039410092,0.07090203,0.0029326947,0.030814908,-0.0010614367,0.020352453,0.027867187,-0.16729338,-0.14757483,0.033603057,0.033755723,-0.042505905,-0.065355316,-0.085468024,-0.014085296,-0.031974185,0.24215797,-0.012599625 +1.14.19.73,"A cytochrome P-450 (heme-thiolate) enzyme found in plants. The enzyme catalyses an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine. cf. EC 1.14.19.65, (S)-cheilanthifoline synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline.",384,1.0,-0.06401569,-0.032629736,-0.102594875,-0.01420863,0.07645852,0.12329961,-0.06302013,0.07294563,0.039127767,0.0237772,0.0067807026,-0.01416427,0.0073649166,-0.05518305,-0.09255711,0.07942991,-0.12861066,0.039785296,-0.009923036,-0.04543808,-0.018333727,0.055514026,0.033625763,0.031398952,0.030850464,-0.01572282,-0.010185782,0.03998574,-0.019144373,0.015332341,-0.009109118,0.027440183,0.021715535,-0.0048094178,0.032052033,0.02954804,-0.01476771,-0.0089858,0.014986426,0.025644163,0.02035102,0.005249591,-0.09586912,0.015244467,-0.057216972,-0.019728186,-0.029908715,-0.010655003,-0.032480743,-0.06371002,-0.05769872,-0.025702924,-0.078923285,0.020165727,-0.031074958,0.014889181,0.04372328,-0.012296967,-0.016220741,0.0067192963,0.058923364,-0.05188807,0.006808106,-0.017588923,0.028824681,-0.045179904,-0.036566466,-0.029447239,0.01965934,-0.088461705,-0.061170258,-0.08562823,-0.02067957,0.05051926,-0.076808795,0.03923827,-0.0155067295,0.0043546357,0.004826251,-0.0014045378,0.014072853,-0.0015696151,-0.07005317,0.077192396,0.05328232,0.036323257,-0.015335383,0.06680721,0.07891665,-0.0056561497,-0.0001842142,0.026133576,-0.069256224,-0.021089213,-0.14420119,0.0018787034,0.047131244,0.04878261,0.0043262057,-0.037224397,0.053762212,0.043659355,-0.027609486,-0.0930353,-0.029752752,0.07756687,-0.01783097,0.048904244,-0.0008505498,-0.0068927123,0.0010613629,-0.07157149,0.02609583,0.009382305,0.023168065,0.089753695,-0.0097834915,-0.036789447,-0.018501732,0.0067277043,-0.039446633,-0.0022513785,0.021645525,0.03573215,-0.03573663,0.0114691155,-0.07964356,3.1970364e-33,0.09088577,0.10746749,0.017587585,0.02765423,0.030047126,-0.025235243,-0.11212693,0.07504259,-0.05104284,-0.034888387,-0.12083171,-0.045696873,0.0138089815,-0.062205616,-0.004260916,-0.04282557,-0.09887365,-0.03012845,0.03472654,-0.021620866,-0.06727736,-0.035178617,-0.058913402,0.0011615576,-0.008319283,0.005636438,0.028562468,-0.016535202,0.017090553,-0.0044981586,-0.025671853,-0.121909946,-0.02654004,-0.050279934,-0.047215562,-0.01412875,-0.006855031,-0.022927739,-0.03911614,0.07802741,-0.03549102,-0.012058724,0.058647472,-0.010829566,0.06683338,-0.0346931,-0.104110345,0.08944596,0.05710582,0.06718961,-0.010070278,-0.069713324,0.11636532,0.048350777,-0.097719915,0.05116251,-0.021125713,-0.038605087,0.01503322,0.07736583,0.04879903,0.02130514,-0.011431413,0.014621705,0.045983203,0.062053908,-0.038315345,-0.034031637,0.006372961,0.07020127,-0.07160788,-0.0025950728,0.07054395,0.04946829,0.040147383,-0.021923872,-0.035580844,0.07109674,0.069261685,0.027556228,0.041024655,0.021564972,-0.05835023,0.048151664,0.0018952532,-0.045426693,-0.026225463,-0.044278216,-0.022247015,0.07586974,0.0177356,-0.1190962,-0.014218082,-0.0031455567,0.004446604,-2.8354966e-33,0.07241674,-0.06293291,0.015794544,-0.08520486,0.0038512496,0.04075839,-0.045926306,-0.0181856,-0.0064913407,0.00208158,0.09042837,-0.008964658,0.06406908,-0.057046503,-0.014545131,-0.0844024,0.058632385,0.055684865,0.018438108,0.021710902,0.024108332,0.019253995,-0.052831117,0.009836347,0.03486018,0.038196392,0.015033368,0.016980119,0.052044135,0.056343302,0.031009588,-0.013088043,-0.065536484,-0.0399991,-0.011048802,0.10705777,-0.008285454,0.057374172,0.052324776,0.07070342,-0.038391307,0.017649965,0.058941815,0.044486865,0.06642744,0.048862036,-0.12884697,0.00081175426,-0.014352039,-0.05314409,0.052182425,0.051179256,-0.059670374,0.01245179,0.0423882,0.07180519,-0.004677248,0.0047244607,-0.06551246,-0.043944553,0.026513679,-0.03629826,-0.01332932,0.013552721,-0.008774198,0.07877471,-0.056726612,0.061613563,0.0980738,-0.011557858,0.0089623025,0.018515252,0.02325435,0.07428747,-0.022042843,-0.011589112,-0.008900088,-0.02527206,0.013260367,0.025809435,0.009962303,-0.016833292,0.037130237,-0.065671764,-0.027203655,-0.083365865,-0.046221796,0.10465111,0.07451531,-0.049600188,-0.006972687,0.031078001,-0.081111416,0.076389484,0.055781566,-4.5655252e-08,-0.004467295,-0.07320558,0.06003767,-0.0035618155,0.020201238,0.008425957,0.06747353,-0.06419529,0.08199303,-0.079498045,-0.020819537,0.04702738,-0.024685737,-0.009147165,0.05377241,0.0043586404,-0.013403231,0.025265664,-0.009151429,0.029229393,-0.05127311,0.033703573,-0.090143785,0.0046552406,0.011796084,-0.068098895,-0.031441476,0.029899562,0.0319599,0.04134441,0.08303497,0.018294789,-0.020652274,0.026848387,-0.0029765938,0.00036539193,-0.033287916,-0.040142596,-0.011860537,-0.035878606,0.02960368,-0.016625242,-0.08270235,0.027422205,0.07277357,0.030655574,0.03826187,0.052757367,-0.013709251,0.01954547,0.0047133276,0.025087526,0.03310028,-0.113095276,-0.13377605,0.034793053,0.04326876,-0.04817441,-0.063491695,-0.11182062,0.00859275,0.021770887,0.23677175,0.017735897 +1.17.9.1,"This bacterial enzyme contains a flavin (FAD) subunit and a cytochrome c subunit. The flavin subunit abstracts two hydrogen atoms from the substrate, forming a quinone methide intermediate, then hydrates the latter at the benzylic carbon with a hydroxyl group derived from water. The protons are lost to the bulk solvent, while the electrons are passed to the heme on the cytochrome subunit, and from there to azurin, a small copper-binding protein that is co-localized with the enzyme in the periplasm. The first hydroxylation forms 4-hydroxybenzyl alcohol; a second hydroxylation converts this into 4-hydroxybenzaldehyde.",384,1.0,-0.096268915,-0.059886403,-0.11437243,0.0075631603,0.08297787,0.01694029,-0.010531913,0.07716798,0.04828515,-0.07152981,0.04116519,-0.068695314,-0.049428996,0.0728006,-0.10239469,0.010976225,-0.10474772,-0.015903834,-0.009415795,-0.0049772244,-0.011213991,-0.004032266,0.029088665,-0.0068849185,-0.0062983385,0.011679474,0.08877283,0.012082143,-0.0058319164,-0.025725655,0.07440541,0.0010753338,0.05786246,-0.0405326,0.05937104,0.08591737,0.05099173,-0.08523838,0.09530265,-0.017662117,0.034312524,0.023868453,0.057104822,0.017203283,0.051618293,0.040695842,0.0819266,0.11098266,0.01412527,0.027568193,-0.03399748,-0.07032921,-0.056574453,0.0682599,0.022541938,0.028640836,-0.052734282,-0.07675837,-0.024146488,0.04265984,0.03422577,0.039536342,-0.035013564,0.053818606,0.0052906787,-0.06369183,-0.0152590275,-0.04042922,0.046562187,-0.02471908,-0.04934204,-0.049531102,0.012948021,-0.010181973,-0.030281393,-0.0046377126,0.019747863,0.0007261996,0.048587732,-0.008942546,0.007978914,0.013470516,0.05038828,0.14106633,0.012710699,-0.074595354,0.040664084,0.013474499,0.005435424,0.043014556,-0.015188014,0.044815212,-0.035222165,-0.11165679,-0.117727004,0.04510498,0.07847214,0.022503778,0.033876147,0.011725731,0.0012525993,0.037424084,0.102852404,-0.079701066,-0.059574116,-0.03481139,0.0039638313,0.16224499,0.05184155,-0.023255613,-0.010248544,0.019294357,0.03838541,-0.07190879,-0.025661709,0.069573425,0.0153309945,-0.07828285,-0.07825474,0.041827064,-0.066174604,-0.030234767,0.083987184,0.03879822,-0.0033844227,0.003017198,-0.141538,2.9132703e-33,0.07362159,-0.024766574,-0.06440125,-0.03123431,0.02285904,-0.01330159,-0.041758236,0.008601444,-0.072179094,-0.00970109,-0.02630355,-0.062428016,0.046512384,0.012801626,-0.03539247,-0.010857681,-0.07599207,-0.04671412,0.039057583,-0.017330997,0.049747802,0.039833654,-0.018411426,-0.010992418,0.05913728,0.039626576,-0.0052764504,0.03612355,0.020625437,0.0076844404,0.0057186917,-0.044476382,-0.06529039,-0.02897941,0.029489402,0.021992706,-0.06879045,-0.060570847,-0.029468738,0.06710965,0.0389687,-0.007228504,0.0450099,-0.031391524,0.060196243,-0.05982323,-0.06611232,0.11712635,0.024178987,0.041787364,0.0721496,-0.021841263,0.06836596,0.010641899,-0.12626682,0.049981892,-0.024282694,-0.001017063,-0.0007067362,-0.043302838,0.045392755,0.047395676,-0.049891505,0.05438142,0.015494783,0.0154514,0.020828927,-0.06785216,0.07335694,0.08955044,-0.063120894,-0.041167278,0.055548746,0.009088384,0.015998794,-0.027842019,-0.041101817,-0.04199234,0.07274033,0.010328453,-0.048350777,-0.029979246,0.06184269,-0.009782915,-0.02745691,-0.04402231,-0.0039114715,-0.046102587,-0.033495136,0.0008371015,-0.0028104875,-0.14080967,-0.03535286,-0.02424337,-0.003668908,-3.1937208e-33,0.040145077,-0.07811932,0.021974461,-0.084720895,-0.05450319,0.03851411,-0.025723154,0.0008854626,0.0038015577,-0.012184405,0.07460933,-0.022640841,-0.01747311,0.0034053377,0.021828825,0.0702094,-0.008096366,0.019884383,0.035764884,0.017573997,0.013516362,0.016002825,0.04327034,0.03807692,-0.0128182,0.007641404,0.05667843,-0.02233049,0.057912223,0.096703105,-0.06044762,-0.016093364,-0.030828683,-0.05433094,-0.067623906,0.03884324,-0.04172945,0.004246717,-0.019990677,-0.011079831,0.08124778,-0.036132365,-0.008787514,0.028190205,0.00635919,0.09675393,-0.10596534,-0.00016221947,-0.06299672,-0.029128566,0.03671531,-0.0076682908,-0.016264899,0.057730816,-0.0103588635,0.022685748,0.041110724,0.00027288374,0.012237065,-0.05485354,-0.0711403,-0.13821805,0.03140661,0.0061823432,0.04843148,0.05337553,-0.018315142,0.12568359,-0.010554224,-0.042200264,0.071430705,0.0065258173,0.059069954,0.06630108,0.00016378974,0.010205883,-0.03500343,-0.030449122,0.008487532,-0.004286825,0.047495935,-0.008216844,-0.007863127,-0.056816153,-0.00905881,-0.0643069,0.04755687,0.096227966,-0.009528279,0.024191057,0.02091702,0.09258965,-0.010340783,-0.02867287,0.041724205,-4.0899238e-08,-0.04168073,-0.054699026,0.0401774,-0.0009964774,-0.00020768406,0.08395298,0.008194896,0.018881222,-0.020828113,-0.032409064,-0.022188623,0.084599614,-0.02529349,-0.0051734876,-0.005619872,0.024496451,-0.06779176,-0.0074254833,-0.046654876,-0.027745485,-0.119974345,0.03348017,-0.013219473,0.022770831,-0.0074285986,-0.018118909,-0.03798465,0.03662709,-0.06094809,-0.018849006,0.003921927,0.07469651,-0.024107235,-0.016049294,-0.1317649,-0.0061414153,-0.004522151,-0.08138419,-0.08746084,0.05719332,0.034112833,-0.019992655,-0.07657152,-0.01452829,0.018850222,-0.011473513,0.013906706,0.05983368,0.009682899,0.034388013,0.087307006,-0.025380535,-0.0030366797,-0.059856493,-0.0848536,-0.04684795,0.009111785,-0.059115134,-0.021823382,0.0059238905,0.015214278,0.045330524,0.18277285,0.010259046 +1.1.1.414,"The enzyme, reported from the human gut bacteria Escherichia coli and Bacteroides vulgatus, participates in an L-galactonate degradation pathway.",384,1.0,-0.023019569,-0.098797895,-0.005341933,0.019438425,0.051619515,0.017719477,-0.08752919,0.06070613,0.030477779,-0.02880035,-0.02119016,0.001184598,-0.035971303,0.06279201,-0.0688172,0.009326065,-0.069810234,0.016248144,0.0269428,0.02206045,0.12608542,0.06901565,-0.02506767,0.042481836,0.06837133,-0.029214263,0.04623414,-0.074686475,-0.04352595,-0.046213724,0.02720142,-0.033160504,0.14032677,-0.031599402,-0.009047942,0.12439895,0.0035160517,-0.07161629,0.07426619,-0.012976275,-0.061894707,-0.079041325,0.02653885,-0.053120106,0.0043488867,0.0029903061,-0.017661152,0.027084826,0.022713725,0.03230485,-0.053263254,-0.04555044,-0.02163415,0.02100054,0.016506325,0.069660194,-0.02602446,-0.107409745,0.003736364,0.034375124,0.0733866,0.05944988,0.023159863,0.029042616,0.0020529854,-0.044490967,0.065527745,-0.03657081,0.002232448,-0.043278594,-0.07757202,-0.053152785,-0.031045869,0.021899262,0.05576875,0.0062757656,-0.009644899,-0.023114124,0.013459396,-0.047342386,0.068361826,0.03411502,-0.018249819,0.028533062,-0.003386125,-0.028238304,0.04162273,0.051712785,0.03867227,-0.008732994,0.0032944577,-0.040614434,-0.0021431749,0.003818119,-0.039899755,0.008628448,-0.005514808,-0.06708721,0.0668766,-0.03423285,-0.08138254,0.02178947,-0.019826798,-0.031783152,0.02002225,0.050197102,0.0045369873,0.12518156,-0.013118088,-0.02856879,0.111581385,0.0010432056,0.016165309,-0.011193108,-0.015644126,0.05167935,0.057660203,-0.032545343,-0.11132343,0.08356721,-0.04061301,-0.008665622,0.014524775,0.021613251,-0.010593957,0.040647995,-0.00039675424,6.640804e-34,0.05215487,0.0030595378,0.011323092,-0.0071001356,0.049957853,0.007395693,-0.06713817,-0.034106284,-0.0035631969,0.012251589,-0.056722183,-0.06941013,0.011599306,0.06306785,-0.0110659385,0.11628446,0.012403672,-0.037968736,0.0007680184,0.0013018672,-0.012412975,0.037354227,-0.027800411,-0.017100485,-0.009933746,0.058968607,0.04575334,0.033659425,0.027272513,-0.017538827,0.01379261,-0.093778,-0.0907084,0.009242913,0.080242194,0.03993654,-0.053859495,-0.06480155,0.0095967,0.039456904,0.022251956,0.058061138,-0.043252382,0.008008525,0.035773132,-0.045205142,0.0109273605,0.096266486,0.027991135,0.037778113,0.10890969,-0.023426874,0.0040797745,-0.024361912,-0.03682197,0.031058665,-0.031261638,0.05748569,-0.00064697204,0.028102616,0.067071855,0.038836975,-0.019079892,0.091540314,0.027258167,0.007895469,0.013337936,-0.026490968,-0.037086785,0.051968396,-0.11356498,-0.07422887,0.06789568,0.025629915,-0.0027654958,-0.048599143,-0.07656546,-0.0024744754,0.048939675,-0.045827392,-0.04479693,-0.021509666,-0.0039773583,0.026385343,0.010872233,0.075292595,-0.04169175,-0.058737542,0.04505973,0.037867494,0.021388238,-0.083688684,-0.02995457,0.060296338,-0.049831618,-2.3316983e-33,0.04360607,-0.07684205,0.035816897,-0.04873569,-0.09308989,0.031164698,-0.02238644,0.036238037,-0.007697464,-0.013655791,0.060999926,0.026864542,0.043238517,-0.07407886,0.017010272,0.035212927,0.08418721,-0.020601299,-0.08114157,-0.016085682,0.00793378,0.08048947,0.011265434,-0.043450784,-0.001278325,0.010182181,0.03148137,0.07125829,0.04095764,0.021116732,0.027805703,0.012638769,-0.043662272,-0.15885393,-0.04740254,0.054485187,-0.07306135,-0.01745787,0.03742589,-0.030195365,-0.02151657,0.05153863,0.021224393,0.027534578,0.0084799025,0.08914732,-0.043660652,-0.023859108,0.032716133,-0.05503574,-0.00718853,-0.052186076,-0.007611059,0.0019372479,-0.053514905,0.029444346,-0.012731135,-0.021291997,0.04779356,-0.03956947,-0.006282649,-0.032660827,0.060675703,-0.016955698,0.033418845,0.009030328,-0.03066641,0.046196673,-0.022101443,-0.04858177,0.09806579,-0.014415302,0.010358912,0.037659977,-0.04614265,-0.00646485,-0.1443091,-0.09802426,0.008797555,-0.020358969,0.03557207,-0.009464014,-0.015903743,-0.045567907,0.024784472,-0.092951976,-0.013797433,0.17340145,0.041907772,0.033698253,-0.03530666,-0.043093883,-0.07871574,-0.07735391,0.06657536,-2.7717356e-08,0.06996682,-0.018381728,-0.012289944,-0.08281657,-0.020798592,0.02863174,-0.018001938,0.07677562,0.05335947,-0.036614105,-0.0714733,0.11676756,-0.050880373,0.005895727,-0.035248328,0.06759557,-0.011806315,0.022100007,-0.0520597,0.010672501,-0.071586445,-0.021953851,-0.041979473,0.025924018,0.036836993,-0.050871618,0.07262006,0.092378154,-0.019653244,-0.11865256,0.050573748,0.07770028,0.06551659,0.017225033,-0.09152584,0.04598593,-0.047800597,0.0043556932,0.03770035,0.029444924,0.018380605,-0.005126503,-0.047152042,-0.020728664,-0.085305266,0.032426994,-0.031092562,0.0713015,-0.034137946,-0.00679168,0.010502066,-0.07071851,-0.08779308,0.027229654,-0.045808576,-0.07821142,0.02323679,-0.067558885,0.062455658,-0.11336677,0.009008089,-0.0542496,0.15154454,-0.071522206 +1.13.11.86,"Requires iron(II). The enzyme, characterized from different bacteria, is a nonheme iron dioxygenase in the bicupin family.",384,1.0,-0.02927261,-0.029363647,-0.049228523,0.055826697,0.058407243,-0.03903913,-0.03616551,-0.003173382,-0.0024456128,-0.043067932,-0.06685197,-0.14369693,-0.055835385,0.076694384,-0.014459004,-0.028535863,-0.028979037,-0.044217866,0.01476958,0.018820083,0.054092143,0.051791314,-0.009936591,-0.024919823,-0.027621463,-0.015206523,0.074021205,0.023038289,-0.048258033,-0.010426107,-0.022363648,-0.014824732,0.08384815,-0.051064204,0.013530801,0.077137955,0.022763137,-0.034419537,0.06796223,0.025475157,-0.02117331,0.017897021,0.0261481,-0.057849783,-0.002157312,-0.014991706,0.053746928,0.00044499536,0.011317012,0.04787646,-0.084277265,0.005546506,-0.04476441,0.04923566,0.040594004,-0.006302827,0.024018355,-0.04320268,-0.049957916,-0.016346166,-0.0022056368,-0.07299602,0.015576807,0.03043221,0.012379011,-0.04893194,0.02576675,-0.021732096,-0.0038308434,-0.055361163,-0.025206901,-0.00017544311,-0.11330518,0.013465436,-0.022294294,0.0656552,0.05514427,-0.059224393,0.05528257,-0.034870565,-0.10744305,0.00919198,0.016362958,0.099028274,0.018991584,0.021706479,0.024295397,-0.03796151,-0.087216966,0.04468913,-0.013790412,0.032715686,0.026466718,-0.078149356,0.08107876,0.024974773,0.022538163,0.0604896,0.004289175,-0.016164694,-0.08589376,0.032556504,-0.025177317,-0.040751733,-0.023295935,-0.021534588,-0.008656094,0.08496754,0.042262863,-0.0066435854,0.08615128,-0.021052249,0.09969149,-0.00076561264,0.03292875,0.06992324,0.0934847,-0.09266639,-0.06463632,0.11793014,0.031915117,-0.032489754,0.030494113,0.019746704,-0.056415427,0.004140831,-0.022411937,-9.6597295e-34,0.028104352,-0.008238369,0.027554005,-0.019927252,-0.04655395,0.035826366,-0.13179944,-0.052136455,-0.04912366,-0.022197695,-0.076622866,-0.036340926,0.069377065,-0.015079954,-0.016937064,-0.034277722,0.02772626,-0.059978772,0.07483757,0.029959122,0.055119902,0.0748339,-0.00372465,-0.025877483,-0.00075171026,0.09305233,0.041777644,-0.00034947586,-0.031896587,-0.009398867,0.07246683,-0.102313936,-0.08930266,-0.01898152,0.08638999,-0.041922,0.015624326,-0.003947612,-0.06800404,-0.0063043833,0.038956203,0.06635303,-0.01911363,-0.04116983,0.1186909,-0.09525159,-0.027916228,0.09534846,-0.024287269,0.12305681,0.03095761,0.03790857,0.09555207,-0.03614743,-0.04129064,-0.01936462,0.005936636,0.031202445,0.06909703,0.11179787,0.03411402,0.07091099,-0.023968255,0.13031511,0.047510494,0.047273554,-0.040007833,0.0029800977,0.021676984,0.04357461,-0.033562854,-0.0045469105,0.031996936,0.0017938106,0.009349855,-0.081054255,-0.03992281,0.0081937555,0.06905807,-0.027512692,-0.008475114,-0.0015917543,-0.026767723,-0.031123647,-0.08757991,0.00899033,-0.066284135,0.035803135,-0.0070367116,-0.0055560665,0.06785122,-0.024216771,-0.0977464,-0.014580782,0.027804583,-9.928045e-34,0.07316627,-0.068781726,0.056158282,-0.08872256,-0.048802696,0.10283115,0.0126891155,-0.10975074,0.030733254,0.019367846,0.08180672,-0.020006163,-0.00032714027,-0.060873233,0.010545331,0.059088264,-0.043932717,0.044172097,0.0035698728,-0.010125222,0.005170873,0.09323868,-0.003381859,-0.0171562,0.021233689,0.045847226,-0.109960966,0.020799698,0.022994045,0.047923736,-0.041949615,0.034400504,-0.03275449,-0.120204546,-0.008320737,-0.018065494,-0.03786782,0.013773546,0.0085574575,-0.00792403,-0.023193551,0.042998157,0.04389322,0.1264933,0.0181609,0.038651675,-0.08083186,-0.0023652464,-0.014331257,0.022628762,-0.03752205,-0.06552626,-0.024914145,-0.029135112,0.007114912,-0.00088945427,0.010916613,0.08331252,0.0024695508,-0.0033658869,-0.00895998,-0.05598759,0.07966999,0.022642246,-0.005417009,0.005843946,-0.0636931,0.07077262,0.047113903,-0.030991303,0.043324314,0.0010641383,0.07726573,-0.06413786,-0.006849233,0.038873397,-0.043896135,0.031006027,0.007665391,0.06091283,-0.029866131,0.0012601133,-0.040416107,0.0078188665,0.0044242614,-0.14666194,-0.0055654338,-0.045259237,-0.024941504,-0.020673685,-0.05912457,-0.071447514,-0.0097064,-0.032617968,0.026456214,-2.840025e-08,-0.0051110564,-0.07658892,0.0722001,-0.043266103,0.013542713,0.00691968,-0.044995405,-0.037281428,0.023421664,0.018329423,0.0636426,0.1002173,-0.007662415,-0.00031767003,0.050099425,0.04285715,-0.0027686423,-0.024145983,-0.0207939,-0.0035143313,-0.046029914,-0.039029714,-0.0753737,0.06548066,0.0028737974,-0.06700718,-0.021568554,-0.050491996,0.0015158394,-0.02557206,0.0014344292,0.059081793,-0.011609343,-0.044128895,-0.14221337,-0.020097546,-0.019725587,0.030481426,-0.05337789,-0.0039863917,0.0073198206,-0.010811359,-0.08562677,-0.033747815,0.004372301,0.027117053,-0.016894678,0.051225003,-0.020746881,-0.032794584,0.04981086,-0.041194588,0.035105232,0.034660134,-0.07757421,0.0930211,0.06580425,-0.076139264,0.03702392,0.0044593136,0.04641265,0.04817874,0.1724145,-0.075959906 +1.14.14.155,"A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid. Involved in the degradation of (-)-camphor. Requires a dedicated NADH---FMN reductase [cf. EC 1.5.1.42, FMN reductase (NADH)] [1,2]. The product spontaneously converts to [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate.",384,0.9999999,-0.081428014,-0.022211017,-0.13470149,-0.0058423067,0.09247823,0.06632332,-0.12707885,0.048642986,0.029649314,-0.047644112,0.060164683,-0.07816901,-0.044095922,0.075799555,-0.024651792,0.029980766,-0.06259722,0.024497937,0.004084926,0.017815735,-0.019679846,0.07316395,-0.0070372284,0.0065492573,0.0398646,-0.008667081,0.030450974,-0.02010995,-0.08521626,-0.018770492,-0.026122158,-0.0528495,0.03821308,-0.08587173,0.07889643,0.040556706,0.023230996,5.8862515e-05,0.076478206,0.005730669,-0.058629982,-0.012358542,-0.022827704,-0.09531897,-0.0856993,-0.023498058,0.08190538,0.04094949,0.025205517,-0.07124548,-0.050132137,-0.022544706,-0.0037636235,0.0025759945,0.07347213,0.009897294,-0.0067915493,-0.07796908,-0.0829815,-0.0050547672,0.0024369485,-0.015549788,-0.0063871117,0.0121838,-0.07235006,-0.018306343,0.032345332,-0.024693603,-0.016414177,-0.04976232,-0.033926144,-0.077734925,0.02350622,-0.045550346,-0.033371877,0.02839904,0.03841459,-0.03244386,0.114125095,-0.0024360537,0.017845402,0.024113666,0.01872187,0.05399544,-0.0052929423,-0.05679619,0.08098584,0.024797576,0.06384946,0.06755206,-0.02530395,-0.03274772,-0.049004737,-0.03701509,-0.04768097,0.010156753,0.045467444,0.074702755,0.01821439,-0.013221775,-0.012297782,0.013971819,0.04647167,-0.06808078,-0.07346686,-0.00017027534,0.018579897,0.15803231,0.031203868,-0.020457953,0.065968245,0.032493588,0.015183669,-0.016054304,-0.06396774,0.114802934,-0.019344112,-0.115241386,-0.12900658,0.041330133,0.0036074435,-0.04013578,0.027759383,0.052026846,0.009441908,-0.005572166,-0.046935488,4.264508e-34,0.037118662,0.02618015,0.006994123,-0.001662095,0.07518278,0.05099242,-0.08993509,-0.002388139,-0.02499063,-0.0049325805,-0.01588895,-0.08072328,0.0024373569,0.027150402,0.00724065,-0.04551415,-0.068278424,-0.031733148,-0.0036731337,0.0058921417,0.023193218,0.02899405,-0.018807694,-0.014543558,0.023699002,0.0049183914,0.05615331,-0.044642825,0.058047704,0.0159319,0.059397433,-0.08221927,-0.08843007,-0.03172531,0.037271596,-0.015844164,-0.063682,-0.019331232,-0.06493225,0.038261384,0.08354804,0.16009322,-0.0850735,-0.043050524,0.07753199,-0.117163755,-0.03714595,0.18874337,0.029472677,0.14549214,-0.029783733,-0.013718243,0.02620256,0.013898948,-0.029518481,0.026352508,-0.033885024,0.04739619,0.046076305,0.03307562,0.003828839,0.036916286,0.0013859312,0.008583226,0.03451237,-0.005418916,-0.0501521,-0.00026149402,0.0064339666,0.0033725244,0.018382212,0.043008436,-0.02180903,0.023986438,-0.027604207,-0.09169488,0.0044129808,0.042228952,0.036750555,-0.028324941,0.025240263,0.039638072,0.016144115,-0.04158627,-0.07710589,0.006028214,-0.030534867,-0.031581726,-0.05744264,0.055325415,0.10272843,-0.07378351,-0.023433585,-0.045854088,0.009251093,-9.990318e-34,0.031261604,-0.058957838,0.03356417,-0.12942238,-9.490591e-05,0.045635108,-0.017057,0.051537264,-0.017345015,-0.012654963,0.0033919173,0.08228418,0.041181434,-0.043735176,0.02496263,-0.008120411,0.0355979,0.00097016356,0.020682056,0.009290049,0.024060136,0.023384394,-0.033831425,0.02430895,0.04992667,0.052970808,-0.06600398,0.13530318,0.03290959,0.059689045,0.045641657,0.044611223,-0.059325986,0.022191003,0.069951095,0.056585357,-0.023808485,0.03404978,0.056238543,0.09057432,0.003749716,0.0148553215,-0.0777128,0.040638372,-0.0056813033,0.05820795,-0.15674563,0.019296873,0.07676613,-0.13989674,-0.053016387,-0.024713134,-0.031256557,-0.021909405,0.012222728,-0.03782952,0.0064860014,0.022988211,0.007724521,-0.070758596,-0.010911607,-0.057413027,-0.020437546,0.012141082,-0.016405234,-0.008761192,0.025770497,-0.016503232,-0.0011914513,-0.0038965007,0.016138496,0.0052063456,-0.0091422545,0.0019754271,-0.051474653,-0.051392563,-0.013215285,-0.0051594456,0.0038411254,0.0065228376,0.06490769,-0.082625024,0.00038981938,-0.08680587,0.053259682,-0.03851553,0.076782204,0.085492365,-0.055002715,0.0012295428,0.0019248798,-0.008039729,-0.029289994,0.04548249,0.06816941,-4.5241197e-08,0.049582247,-0.12695101,0.06422236,0.017652316,-0.032108936,0.031954445,0.019413257,-0.026820056,0.023747249,-0.05417349,0.024993507,0.05810721,0.021704508,-0.009711172,0.056694947,0.028104534,-0.08178595,0.027775794,-0.028739017,0.037989877,-0.07403602,-0.01800522,-0.051150996,-0.0003499056,-0.04440835,-0.01831918,0.059932344,-0.018550612,0.021388251,-0.039355475,0.044277508,0.047248185,0.0069376687,-0.013996035,-0.11716817,-0.03419317,-0.04128936,0.057348773,-0.06923432,0.034117263,0.040423684,-0.050591636,-0.053497314,0.008797723,0.029692762,0.033026002,-0.0011194542,0.013696884,-0.014134477,-0.015244596,0.059595797,0.0126688415,0.013331085,0.016256573,-0.07500776,0.06037201,0.01790182,0.0008916033,-0.039512213,-0.0044810656,-0.01953351,0.05037755,0.10127007,0.03535365 +1.14.14.156,"A cytochrome P-450 (heme-thiolate) protein from the plant Arabidopsis thaliana. This enzyme catalyses two successive N-hydroxylations of L-tryptophan, the first steps in the biosynthesis of both auxin and the indole alkaloid phytoalexin camalexin. The product of the two hydroxylations, N,N-dihydroxy-L-tryptophan, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme.",384,0.99999994,-0.042504065,-0.005686681,-0.026166154,-0.008613035,0.091984905,0.061129317,-0.0384858,0.07366576,0.039375193,-0.012339596,0.057786778,-0.04291646,-0.06573297,0.02569663,-0.054486543,0.0641728,-0.04099867,0.025563316,-0.0017615876,-0.052067097,0.03581667,0.09469663,-0.02848284,-0.014875291,0.028513318,-0.049231306,0.008922377,0.024542592,-0.027155757,-0.026620058,-0.03425133,-0.016066164,-0.0067907795,0.006183977,0.0020034066,0.1143598,-0.02294638,-0.08197002,0.09216064,-0.01473876,0.003071989,-0.0141585935,-0.09371931,0.016542172,-0.05879141,-0.0077684163,0.01964523,0.039250962,-0.009182061,-0.090275735,-0.011775791,-0.025011955,-0.03137022,0.009126589,-0.010299419,-0.0323091,0.019243361,0.04287953,-0.013557718,0.04997747,-0.0052924925,0.054025695,-0.026021194,-0.008433274,0.072838664,-0.048539348,-0.045915514,-0.022981543,0.034413304,-0.04981326,-0.021970205,-0.055481143,-0.0278492,0.015831674,-0.053760488,0.060994875,-0.06543295,0.034386683,-0.04597059,-0.033079933,0.04037163,0.029666448,0.015638806,0.13991004,0.014802461,-0.037280347,-0.07176326,0.13197738,0.035938285,-0.040962934,0.042820357,0.028365934,-0.04004412,0.07022831,-0.034307774,0.08992686,0.050033152,-0.04640532,-0.012402907,-0.026287513,0.027591446,-0.009634904,-0.08068487,-0.10227309,0.02236574,0.0020795357,-0.0028013175,0.01876138,0.06263939,-0.03332041,-0.04240837,-0.063722424,0.034917198,0.030173583,-0.02928215,0.0788746,-0.06895484,-0.023179041,-0.034542266,-0.08233512,0.01955066,0.021031639,-0.0023762728,0.034141406,-0.06686521,0.023601264,-0.10510922,4.987717e-33,0.09886961,-0.0006305164,0.0007606157,0.055213355,0.004834264,-0.02831969,-0.06569206,0.038002048,0.0125162555,0.008839432,-0.08244571,-0.10174545,0.00732792,-0.050493095,-0.020060616,-0.015718503,-0.15654254,-0.009901148,0.040430695,0.053173136,-0.05759476,-0.065636605,-0.08695669,0.0035296623,-0.055640325,0.06548236,0.026609188,-0.05151411,0.061359067,-0.013821702,-0.056891985,-0.10214405,-0.07006216,-0.027490305,-0.0024089126,-0.0434416,-0.0014374224,-0.00082389184,-0.11004691,0.024568133,-0.023566501,0.083480015,-0.0060165497,-0.045705594,0.09479532,0.022420367,-0.078757584,0.093339495,0.019909823,0.04513243,0.042901106,-0.017057404,0.05983425,-0.014561212,-0.05622203,-0.014438665,0.023081202,0.039791975,0.033505663,0.07993737,0.010978173,0.017276881,0.014724066,0.017086232,-0.029176507,0.06858267,-0.061221644,-0.0816322,-0.010285185,0.1057854,-0.0746342,-0.0061618704,0.09884547,-0.030023204,0.0056245094,-0.058337685,0.041103337,0.044828877,0.026336601,0.019916529,0.08353017,-0.011682553,-0.012389313,-0.008252166,-0.0056115687,-0.0153425,0.00082282186,-0.029568061,-0.04716525,0.08278055,0.05497219,-0.02029437,-0.0008337684,0.006684538,-0.0054470734,-4.2116115e-33,0.07020673,-0.06911299,0.013263422,-0.08115148,-0.01248612,0.03421127,-0.013169776,0.012323906,0.06438186,0.001598062,0.06870111,-0.035289485,0.04437654,0.030274287,0.012868246,-0.014870594,-0.013014568,0.11080301,0.010984936,0.049453635,-0.007880589,0.047058843,-0.008720202,-0.01731264,0.074641615,0.050165866,-0.0032048658,0.09626223,0.024460698,0.013957467,0.07378003,-0.0062075513,-0.11818273,0.0025456022,-0.023320787,0.08361932,-0.044061232,0.016745128,0.040873513,0.08941331,-0.016085293,0.03373862,0.040163696,0.0364411,0.010541407,0.051725056,-0.09510403,-0.03555219,0.013097777,-0.06273735,0.051588897,0.009134734,-0.09164518,0.044668768,-0.0012101247,0.05453016,0.019368373,0.047533024,0.015881535,-0.046056684,-0.04349795,-0.037204865,0.021499516,-0.0059435456,-0.057916533,0.053275198,-0.016733035,0.053389266,0.06204732,0.04036296,0.09308025,0.019343786,0.016286762,0.056928527,-0.0338086,-0.01526828,0.0010763801,-0.057834152,-0.01647341,-0.0053889337,-0.0016551897,0.058024567,-0.00687835,-0.048529234,0.017911108,-0.07872304,-0.029124508,0.14992179,0.03624233,0.008521983,0.018118327,-0.034831602,0.01068832,0.09023039,0.09978406,-4.2031196e-08,-0.048755657,-0.08628182,0.010716691,0.008796762,0.011616335,0.037240162,0.060636424,0.04164166,0.053627696,-0.105371,0.022546535,0.019904628,-0.07381829,0.029137848,0.02407764,-0.0070833955,0.0070226067,0.06709588,0.002804238,0.020509534,-0.037695784,-0.006370612,-0.05081077,0.009065551,-0.03479723,-0.044394042,0.041388005,-0.01764098,0.07038728,-0.06804386,0.00568046,0.05834823,0.0018348108,-0.047284205,-0.055117358,0.041643284,-0.06250779,0.0062532616,-0.025073346,-0.058037803,-0.023114285,-0.088763416,-0.081518084,-0.0033975411,0.027094752,-0.055338874,0.033766408,-0.00091691775,0.03401097,0.034655478,0.07755338,-0.023038829,0.04114017,-0.084134646,-0.08206056,-0.00013026991,-0.014002252,-0.023077175,-0.076087244,-0.11834937,-0.00030612518,0.034014437,0.20914456,-0.02085717 +1.14.14.157,"A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses).",384,1.0,-0.09918082,0.057978753,-0.052081846,-0.028475152,0.045059193,0.101815574,-0.0012057868,0.0837863,0.037524957,0.01598472,0.040334057,-0.0022475836,-0.040126543,0.0024149877,-0.056053944,0.08147508,-0.049337726,0.01908755,-0.027751755,-0.079380795,-0.027447352,0.090139344,0.03313592,0.023312282,-0.014426131,-0.013098231,-0.016419014,0.06815265,-0.012954616,-0.051570993,-0.029300056,-0.015204411,0.09004193,-0.02288825,-0.003168156,0.09915677,-0.060770568,-0.088444114,0.023567036,-0.011971036,0.079201326,-0.022642974,-0.10042722,0.023625508,-0.05439369,0.006328173,0.04402703,0.04854074,-0.00058662536,-0.02249312,0.011744713,-0.028704645,-0.046538826,0.010868814,-0.057250515,0.012304297,0.023676807,0.024666173,-0.071696095,-0.043312345,-0.030243564,0.04028815,-0.05415165,0.03638041,0.00657713,-0.05200328,-0.013009462,-0.009351916,0.015662251,-0.08360305,-0.020756336,-0.09914341,-0.039482683,0.04572321,-0.112126246,0.09013561,-0.06529455,0.017124435,-0.0068267733,-0.031992648,0.0637786,0.012006118,-0.007214276,0.10901385,0.06270825,0.0065780003,-0.03463358,0.08799748,-0.018286765,-0.035528895,0.007817663,-0.047438692,-0.0299624,0.044773318,-0.103852876,0.07911729,0.061353203,-0.058275655,0.0011241644,-0.022115272,0.0645199,0.047706455,0.046137225,-0.09246214,-0.05770794,0.012470043,-0.049222194,0.024483258,0.042754345,-0.08718717,-0.07175594,-0.020856645,-0.009209781,-0.022198077,-0.0040254705,0.05671795,0.008640791,-0.034421816,0.0065345373,-0.017116584,-0.061182316,-0.006080076,0.008335292,0.06351233,-0.032914203,0.02995268,-0.14827047,9.9663655e-34,0.10182551,0.025411723,-0.0221921,0.015656726,-0.039835263,0.018679002,-0.06189119,-0.0042946464,-0.05334947,-0.00038470456,-0.07963497,-0.10830841,0.05334182,-0.065617345,-0.02817999,0.009223544,-0.06683308,0.033626374,0.056916084,0.009097138,-0.07598818,0.021468582,-0.09065979,0.021042803,0.027838847,0.110799104,0.004920781,-0.051869538,0.0025495347,0.0032007785,-0.0480891,-0.06347974,-0.07079486,-0.04425673,0.033678003,-0.031672195,-0.049370784,-0.04057355,-0.043311354,0.043757707,-0.05247641,-0.032767992,0.032147013,-0.040987097,0.059735637,-0.02553588,-0.14110251,0.055846523,-0.00026397384,0.062405556,0.07515623,-0.073932305,0.13377467,0.050833248,-0.09314967,0.0049318066,0.01653058,0.075272165,-0.002193335,0.054528654,0.09603882,0.04653793,-0.0739723,0.04045766,0.034870204,0.01137726,-0.06736016,-0.015981086,-0.020902228,0.1640933,-0.028678702,-0.034809597,0.031034674,0.004385971,0.053971846,-0.026671981,-0.0010599956,0.06569466,0.048800252,0.08146071,0.013094977,-0.04131228,-0.018341599,-0.05571471,-0.04787155,-0.0023235104,0.05278749,0.0050909724,-0.0196724,0.0074441317,0.08829586,-0.06810587,0.014680745,0.01447787,-0.0053605046,-2.0761041e-33,0.07703547,-0.040484864,0.054835923,-0.071308106,-0.021437977,0.048579343,-0.016576558,-0.0425703,-0.013463749,0.034496047,0.06840228,-0.025788175,0.018057417,-0.0046400973,0.027897952,-0.029348286,-0.028245382,0.040438343,0.009232983,0.072174676,-0.05862056,-0.024205035,0.020335255,0.03318698,0.022105897,0.007071608,-0.018654406,0.0035027966,0.046229083,0.017424446,-0.039957236,0.020841766,-0.07765828,-0.026495242,-0.019643923,0.037270363,0.007214088,0.02255355,0.035010155,0.019866232,-0.0416018,0.048648257,0.07662014,0.07196687,0.0408345,0.08879701,-0.0982837,-0.024778733,-0.062901825,-0.0007553492,0.025802258,0.060750514,0.03937734,0.06617481,0.005461642,-0.017993053,-0.013044036,0.012553991,-0.047208484,-0.041517496,-0.010703137,-0.03158539,-0.034220427,0.1066403,-0.022973277,0.07193631,-0.058319107,0.0656651,0.0036032586,0.006211196,0.011560382,0.010904744,0.043709405,0.06155793,-0.014539141,0.015336598,0.021475893,-0.02920856,0.030112078,-0.0052460516,0.002037399,0.01888836,-0.05356198,-0.05785992,-0.015722943,-0.07380701,-0.056169827,0.119143784,0.06398656,-0.02834427,-0.0094815595,0.0711629,-0.04110628,0.06318708,0.055299416,-3.4050903e-08,-0.032808788,-0.09526097,-0.00019547023,-0.035396084,0.0383708,-0.023042217,0.013914899,-0.002919575,0.060760453,-0.00872802,0.00016932053,0.038385857,-0.0352624,-0.011122377,0.04870069,0.016039629,0.024893073,0.02536336,0.028206205,0.049332973,-0.035492823,0.029122692,-0.047888312,0.0426745,0.04862024,-0.07243344,0.013030913,-0.040357754,0.055427667,0.012813913,0.045201994,0.038654692,-0.049650837,-0.00590655,-0.015609985,0.076112956,-0.0039792564,-0.06806348,-0.023151219,-0.018268168,-0.022986092,-0.059179813,-0.058123067,-0.03773824,0.03826862,-0.005025452,0.030454468,0.024695408,-0.017092135,-0.020521903,-0.040761787,0.0061095,0.019467391,-0.099318124,-0.12125942,-0.004532937,0.076570824,-0.0540726,-0.015211017,-0.09118583,-0.02581718,0.010934289,0.2125189,-0.007907828 +1.14.14.158,A cytochrome P-450 (heme-thiolate) protein.,384,0.99999994,-0.076557726,0.021021307,-0.01655247,-0.040306345,0.03260365,0.04243468,0.027800782,0.12225458,-0.017934727,0.0028029543,-0.021859327,0.0024067222,-0.028989835,0.034812473,-0.005775227,-0.0036770543,-0.018071055,-0.02581958,-0.00050043897,-0.08541288,-0.03127308,0.038724277,0.0182921,0.02636574,-0.03803794,0.019050516,0.053345747,0.1011325,-0.05031041,-0.024114562,-0.07105179,-0.028481973,0.011488101,0.0037069744,0.0017946754,0.09023362,-0.09615736,-0.066119276,-0.005057367,-0.08180935,0.11370241,-0.007606547,-0.101195574,0.056546967,-0.012107997,-0.022804532,-0.015158996,0.028835203,0.036286253,0.011536441,0.017873617,-0.0390311,-0.04309165,0.033640426,-0.04743065,0.0057979627,0.008518574,0.015373931,0.0057615745,-0.050166022,-0.07919005,0.04527247,-0.004830999,0.02180761,0.052464675,-0.04126035,-0.018201256,0.0029574623,-0.03388583,-0.052162375,0.0005637807,-0.059881117,-0.015335886,0.047584243,-0.085852794,0.05028557,-0.013467036,-0.008354972,-0.0040431856,0.02318205,0.023546888,0.032171153,-0.0015174436,0.13482414,0.039865047,-0.020148432,-0.01658746,0.06395693,-0.08815714,-0.06465278,-0.012753627,0.04495596,-0.0297044,-0.01611324,-0.09985071,0.03490699,0.010771087,0.025702203,-0.01612607,-0.019852757,0.0802109,0.07059758,0.03997678,-0.0944842,-0.04570625,-0.011134278,0.012920966,0.07453531,0.06885478,-0.10593755,-0.03363142,-0.032208186,0.01974633,-0.044115704,0.021073613,0.07258475,-0.0418896,0.011906556,0.0068556946,-0.015799165,-0.05177738,0.017995834,0.011036891,-0.0028119609,-0.053087402,-0.022995746,-0.08626211,-1.888511e-33,0.07134915,-0.0039801523,0.014120266,0.05447009,-0.033561368,0.010767098,-0.06441382,0.059594937,-0.025353353,0.028828707,-0.045717277,-0.09199325,0.025052333,-0.047769226,-0.033841494,-0.016140757,-0.0553254,0.059136085,0.027085397,0.009261081,-0.07858097,0.008559812,0.0009043721,-0.028876504,0.014008461,0.10062849,-0.056679685,-0.031399373,0.008493546,0.0074117472,-0.066748835,-0.03639391,-0.040037878,-0.05514285,-0.006893888,-0.034346342,0.017103404,-0.0062881135,-0.061202563,0.02794562,-0.011271369,-0.047519457,0.014285792,-0.07217621,0.064593524,-0.026908876,-0.12465964,0.015593896,-0.04986793,0.027482746,0.065975055,-0.110297166,0.098831825,0.05774575,-0.095820464,0.0034779955,-0.00829126,0.048915554,-0.010033903,0.051661454,0.14718938,0.08517257,-0.05849207,0.07458315,0.048358094,0.062204238,-0.04666864,-0.028573643,-0.021477783,0.15119852,-0.020945057,0.0064557916,0.095174916,-0.068309814,0.033074196,-0.00057124055,-0.0067515858,0.08380301,0.05710021,0.07743601,0.029423408,-0.050958063,-0.04284672,-0.018648922,-0.008205466,-0.01471776,0.10262148,0.009596691,-0.0025895901,0.04047912,0.06642099,-0.10366235,-0.0066758483,-0.008848656,-0.05483594,1.9187184e-34,0.07791061,-0.064554155,0.0160926,-0.0666495,-0.044080667,0.052029386,0.032278433,-0.024520375,-0.0517679,0.012268372,0.1491134,-0.0692142,-0.02065564,-0.013292579,0.011444492,0.017982706,-0.06380957,-0.0053185266,0.005193084,0.067196734,-0.023129549,-0.056165878,0.037482936,0.023095455,0.02832133,0.039098576,0.018251639,-0.019004798,0.065403745,0.0074452246,-0.060878243,0.06648712,-0.08038039,-0.061106335,-0.04264281,0.03171895,0.03463174,-0.01947865,0.019574806,0.0053710826,-0.04674012,0.09823597,0.03099105,0.07098596,0.026661307,0.12061904,-0.04433869,-0.056289203,-0.030469758,-0.017757442,0.0531803,-0.014810648,-0.037629746,0.04900653,-0.077692054,0.0015392979,-0.03863473,0.034204975,-0.019629156,-0.043892007,-0.03648158,-0.022819055,-0.022991354,0.09737709,-0.009800515,0.07304971,-0.033150822,0.035406984,0.0059652957,0.0040141176,0.0069941347,-0.0060487716,0.08036033,0.07848875,0.028785488,0.01845152,0.033433687,0.014439612,0.08442977,0.01590551,-0.015155269,0.025966492,-0.10963736,-0.0336635,0.012854237,-0.060360778,-0.09711439,0.102968164,0.06217691,-0.038203046,-0.03606107,0.07878413,-0.04779019,0.045995995,0.02633033,-2.2297428e-08,0.016974846,-0.08381897,0.004974508,-0.016902708,0.04014164,0.048908774,0.029055748,-0.010770385,0.03487259,-0.010776895,0.0415482,0.020745121,-0.058542807,-0.03571438,0.0052323844,0.028874232,0.00016745339,-0.004526292,0.070312105,0.021178273,-0.034962628,0.0075812964,0.0018358956,0.016059795,0.059302032,-0.08334029,-0.0015173148,-0.015380438,0.037175838,-0.0044074715,0.011277357,0.03956317,-0.057705883,-0.012825892,0.09734656,0.037359748,-0.044605613,-0.02571888,-0.045587547,-0.0036487838,-0.022025798,-0.0475482,-0.0788328,-0.05563893,0.031953637,-0.034702126,0.07980083,0.059474077,-0.04003338,-0.06406798,-0.067047626,0.0013546454,0.007274123,-0.08580903,-0.10747454,-0.007040259,0.07323971,-0.08430555,-0.055636585,-0.10075465,0.02169638,0.0053255167,0.13734174,-0.011846996 +1.14.19.74,A cytochrome P-450 (heme-thiolate) protein. Isolated from Sesamum indicum (sesame) and S. radiatum (black sesame).,384,1.0,-0.0773104,-0.0010943586,-0.05119915,-0.0026258733,0.019495917,0.096399106,-0.02132976,0.09135874,0.03021532,-0.043207474,0.07184631,-0.05267444,0.000603533,-0.052105032,-0.018587159,0.004029696,0.10814916,0.010742494,-0.0026323292,-0.115316525,-0.03090455,0.074717745,0.028801711,-0.012161453,0.04830333,0.015148488,0.009717396,0.04429807,0.0125488015,-0.056211628,-0.026325537,-0.05463313,0.08037423,-0.02887021,0.02485349,0.032861605,-0.07500865,-0.08113103,0.05559024,-0.037711617,0.07855206,0.03181297,-0.0759412,-0.030617354,-0.03858104,-0.08015771,0.0040787254,0.0077112485,0.037826512,-0.027673913,-0.010465226,-0.016832896,-0.054887395,0.04892436,-0.049287464,0.00034714304,0.026477702,-0.02772398,-0.08468878,0.027958354,-0.03480272,0.029955344,-0.0042488854,-0.0027159313,-0.0052418136,-0.008569801,-0.033167955,0.046289366,0.053776763,-0.028883671,0.005748307,-0.067664504,0.04720109,0.06769422,-0.07000338,0.024373138,0.011981654,-0.0110121835,-0.00024353889,-0.029556219,-0.009902023,0.010299793,0.024414312,0.07631765,0.013265082,-0.016130256,-0.027669491,0.12849806,-0.04878703,-0.08134919,0.034287047,0.06228932,-0.009435641,-0.06244655,0.0052494262,0.038222373,0.008388131,-0.03527456,0.017738948,-0.025321674,0.09296434,0.0499829,0.037955217,-0.12923928,-0.074843034,0.050344866,-0.053959243,0.0023505357,0.066008426,-0.08972465,-0.009075782,-0.03360162,-0.031506587,-0.062373944,-0.009231765,0.05159897,0.038706083,0.011802356,-0.02061688,-0.04236811,-0.041218672,-0.017001374,0.054394264,0.016532244,-0.025825143,0.00435025,-0.11588472,-5.3025554e-34,0.06815038,-0.01071636,0.010122081,0.014572,-0.029798454,0.03357118,-0.040991526,0.06599284,-0.094102785,0.013314657,-0.07150989,-0.037965637,0.019522443,-0.07569694,0.043536566,0.033488132,-0.05942567,0.033399794,0.054531325,-0.070756406,-0.046082553,0.032690834,-0.038175616,-0.024355188,-0.025090141,0.036813248,0.006700926,-0.06561811,0.0056387517,-0.0017728322,-0.027898584,-0.020596761,-0.09021807,-0.04362659,0.039352205,-0.009394036,-0.042209353,0.028343622,-0.09897163,0.061444085,0.007503014,0.018602911,0.057058882,-0.093804926,0.031793576,-0.01826732,-0.100738384,0.025581168,0.054573834,0.051233638,0.034094587,-0.08746465,0.11884156,0.05228168,-0.05623683,0.002290682,0.007940169,0.07145429,0.0023619758,0.080056265,0.050747592,-0.006607058,-0.096772365,0.042750463,0.045165982,0.054148912,-0.1284173,-0.010356391,-0.026232647,0.08797151,-0.041169558,0.0034113366,-0.010814965,-0.047099594,0.027687306,-0.05321355,-0.00663798,0.069773465,0.0010268111,0.11871931,0.057598025,0.005625674,0.026582988,-0.04722212,-0.035144728,0.008304204,0.027859967,0.076180816,0.045084484,0.059327543,0.083334774,-0.06589123,-0.031375427,0.049941935,-0.050734434,3.9565767e-34,0.041854125,-0.037918683,0.006104122,-0.01890629,-0.017421957,0.0054846182,0.08299322,0.060213808,-0.015878513,0.019135972,0.13199233,-0.00617576,0.047889296,-0.03633487,-0.004226335,0.055594184,-0.04098844,0.09525377,-0.007814573,0.06667483,-0.05645441,-0.0020160628,0.041684292,-0.0011317586,-0.004660534,0.043497737,0.046674978,-0.020677373,-0.012781545,0.0040691737,0.015098291,0.01468226,-0.11149435,-0.06364243,-0.035621878,-0.012455841,-0.012183125,-0.039097022,0.024067212,0.08108077,-0.08584853,0.18563376,0.060406443,0.0671636,0.06603114,0.064342216,-0.066624716,-0.023257948,-0.10592628,0.0059138224,0.04188909,-0.08058927,0.014174266,0.0015928795,-0.01994225,-0.05463255,-0.013506675,0.083795376,-0.036971424,0.0001235296,0.0057123476,-0.030099545,-0.008829752,0.03652808,0.025029978,0.085140966,-0.025879813,0.055779755,-0.018800035,-0.02775715,0.0032127183,-0.01426824,0.015593731,0.038321525,0.04979074,0.038467743,0.031173293,0.00902703,0.024351442,0.029542534,0.04265398,-0.037240587,-0.057262413,-0.039766427,-0.013600594,-0.0125055015,-0.048568893,0.11108715,0.10625345,-0.04010595,-0.055286925,0.05436305,-0.013590835,0.086191766,0.12750366,-2.6958853e-08,-0.038419377,-0.10286137,-0.03517176,0.044488344,0.03348717,0.041790146,0.007632313,-0.040436365,0.03950302,-0.0034729259,-0.034742255,0.035184454,-0.08960098,-0.0025307245,-0.04402055,0.007123276,0.0044596293,0.03074975,0.075194,0.030185733,-0.010821062,0.031086612,0.018472824,0.024706692,0.053822502,-0.070119664,-0.0025277399,-0.03581458,0.098265685,-0.02355878,0.012958532,0.013157241,-0.042125825,-0.01912034,0.014531094,0.00092784694,-0.0603284,-0.029499568,-0.010544327,0.010048556,0.044749666,-0.042201478,-0.018405655,-0.056249354,-0.016946608,-0.03964778,0.022711443,0.06224834,-0.04544465,-0.04829385,-0.057623535,-0.06184085,0.025014333,-0.07261601,-0.06780401,-0.09741731,0.06455299,-0.06541334,-0.036483582,-0.094183646,-0.01033396,-0.004493925,0.08978138,0.045553487 +1.14.20.14,"The enzyme, characterized from hapalindole-type alkaloids-producing cyanobacteria, is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyses the chlorination of its substrates in a reaction that requires oxygen, chloride ions, iron(II) and 2-oxoglutarate.",384,1.0000001,-0.0923258,0.015004491,-0.06198526,0.07734834,0.020939434,0.025458058,-0.009605623,0.036222026,-1.5756621e-05,-0.04106585,-0.028204912,-0.0701787,-0.04857317,0.0061825477,-0.08086658,0.112739764,-0.03887045,0.024807619,0.009320503,-0.0100480635,0.101485275,0.067269646,-0.037514552,0.008243228,0.005359389,0.020973405,-0.00065747404,0.008158563,-0.034116995,-0.014406147,-0.03542673,-0.036472403,0.08925977,-0.04111695,0.05590304,0.031274136,-0.07142324,-0.13809033,0.024162352,0.06390822,0.038438085,0.035040837,-0.065253586,0.05952912,-0.06621701,-0.05643504,0.07264494,-0.011999387,-0.025081046,0.0096906,-0.069806315,-0.0039348346,-0.1030532,0.042174857,-0.035327174,-0.03538219,-0.093224265,-0.0027200435,0.048479237,0.014839813,0.0820638,0.048125315,-0.022586964,0.014818053,0.029728387,-0.09080484,-0.0032599145,-0.045003425,0.013812898,-0.09273375,-0.051790364,-0.05011042,-0.066176035,-0.02714684,-0.00499081,-0.029034553,0.08587953,-0.05745079,-0.02650135,-0.0027058166,0.034619592,0.014696324,0.029767068,0.072914444,0.01538128,0.011243538,0.016850501,0.027182138,-0.025241043,0.023564424,0.083209366,0.014892607,0.0010479447,-0.10081349,-0.016196769,0.07188432,0.0428344,0.07831572,0.03315099,0.034867182,0.01418364,0.012348673,0.011382333,-0.102108724,0.017724348,0.0014584442,-0.021251395,0.012645374,0.06574809,0.014792723,0.018311951,-0.01246677,-0.019074243,-0.0103933215,0.040311735,0.13082665,0.052190676,-0.048681,-0.047599904,0.067723766,0.026081009,-0.065512784,0.043636307,0.059036523,0.021647735,0.013961964,-0.14890243,4.8374407e-34,0.07642102,0.011333246,0.03725785,-0.036437392,-0.012980953,-0.08901303,-0.06787531,-0.045624208,-0.09118957,0.0068998598,-0.10802846,0.050788835,0.0067911553,-0.042369697,-0.0049153105,0.0044107945,-0.055837993,0.025150066,0.09198618,0.037286222,-0.00037806865,0.05224056,-0.0081869485,0.02463833,-0.009562618,0.06455899,0.002004087,-0.021628637,0.015341031,-0.0055860993,0.04909495,-0.09730181,-0.074852265,-0.045129187,0.056666646,-0.056418996,-0.015930086,-0.028000873,0.020163482,0.005993776,-0.076005,0.051471297,-0.0065890606,0.037214775,0.11503006,0.0022525361,-0.088883646,0.058714803,0.024405174,0.05403686,-0.053298317,-0.039836854,0.08588945,-0.008725556,-0.044129908,0.028662235,0.0023092034,0.046114113,0.05455353,0.041591994,-0.001501348,0.034337956,-0.0504623,0.07369922,-0.01502225,-0.0012367038,-0.022804348,-0.016414441,0.064654425,0.058402706,-0.08273626,-0.03572346,0.062468316,0.037675124,0.06291184,-0.08429461,-0.0074850596,-0.026017683,0.027711645,0.04691034,0.020053824,-0.06419188,0.042278253,-0.060178023,-0.062291007,-0.078877725,-0.06111756,-0.028782131,-0.0023542047,0.04196597,-0.00076155283,-0.013164268,-0.07527252,-0.030574245,-0.008044472,-1.5464482e-33,0.10600545,-0.1607649,0.008120655,-0.055712413,-0.025956921,0.041544724,-0.06372797,0.0040832483,-0.04364403,0.06747645,0.10864292,-0.008624413,0.02683984,-0.007631225,0.017306708,-0.018127447,-0.023544049,0.108809285,-0.067252934,0.02293849,-0.060510077,0.054625988,0.03606074,-0.006476143,0.005993379,0.009372484,-0.06452617,0.018631645,0.02385448,0.039841965,-0.054801468,-0.021978587,-0.026621563,-0.06848176,-0.043563608,0.008233192,0.018048717,-0.018311897,0.0100413235,0.075614944,0.027963936,-0.041718163,0.05214238,0.077873796,0.018021027,0.022415118,-0.056974463,0.01868621,-0.004898426,-0.07638109,0.05183388,0.04279671,-0.068907455,0.010861734,0.030246275,0.034234762,0.04233828,0.037535872,-0.039060526,0.0568664,0.012608351,-0.101217315,0.042954788,-0.049902122,0.04963869,0.095607534,0.053738832,0.09301422,0.02949235,0.020870036,0.087890394,0.012654215,0.038960714,-0.026174163,-0.020371836,-0.028052464,-0.015600354,-0.055690773,-0.05709771,0.023294086,0.025690712,-0.011538302,0.043669548,-0.015522439,-0.00026124506,-0.06097336,0.061745632,0.10570914,-0.06496771,0.008002891,-0.0132355355,-0.009175571,-0.058390904,0.11710531,-0.003049548,-3.995651e-08,-0.038164552,-0.056637153,0.04429517,-0.026066862,0.00131432,0.060064133,-0.016613983,-0.02663014,0.005520219,-0.00017656281,-0.0019813052,0.07676844,0.023633517,-0.010765961,0.1282267,-0.0045239287,0.017821144,0.0035833365,0.013562386,0.03928583,-0.03192565,0.011264715,-0.051195435,0.012258995,-0.03220895,-0.09199199,0.029798314,0.024038324,0.020269137,0.030694846,0.0038377305,0.04799986,-0.011102289,0.02299857,-0.12066752,-0.056889437,-0.029369965,-0.09059852,-0.061705302,-0.023408333,-0.044667535,0.018008692,-0.07539062,0.028313998,0.021031398,0.032596372,0.05951886,-0.009269814,0.04104973,-0.047866464,0.00888009,-0.026249252,-0.028423283,-0.03872022,-0.059023913,0.051664155,0.02946529,-0.036360376,-0.038201895,-0.084372945,0.05011893,-0.020827228,0.17181955,-0.018850943 +1.14.20.15,"The enzyme, characterized from the bacterium Pseudomonas syringae, participates in syringomycin E biosynthesis. The enzyme is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyses the chlorination of its substrate in a reaction that requires oxygen, chloride ions, ferrous iron and 2-oxoglutarate.",384,1.0,-0.017722815,0.008716399,-0.10252908,0.015219018,0.05323937,-0.022254739,-0.0041116048,0.057391074,0.057925552,-0.07712959,0.0005872877,-0.039903432,0.024726009,0.10519245,-0.0625189,0.010190282,-0.10469282,0.01609445,0.008660196,-0.023004564,0.111729234,0.056389805,-0.00035994808,0.0018022258,0.023464398,-0.0044985805,0.08057266,0.0092429975,-0.065033294,-0.03096692,-0.041636333,-0.05657563,0.053912226,-0.06573006,0.07239844,0.062624164,-0.0019509966,-0.022609208,0.08479708,0.0058479817,-0.04712193,-0.02027812,-0.04466935,-0.0037056997,-0.015893683,-0.010096519,0.059656262,0.006433462,0.009448292,0.0047041234,-0.04401091,-0.014011961,-0.06928973,0.04729561,0.030516725,0.028389668,0.01114209,-0.074752,-0.04180066,-0.029475976,0.06433028,-0.06139484,-0.018755745,0.045410473,-0.041491468,-0.057503644,0.06648147,-0.07113416,-0.024682388,-0.11905882,-0.09040016,-0.04848003,-0.036867857,0.05282833,0.076437846,-0.058492824,0.007880081,-0.046856277,-0.010288264,0.017257221,0.046863224,-0.03197072,-0.014963772,0.09779468,0.05626529,-0.0012559413,0.067795396,0.0017372633,0.044147637,0.04855511,0.0021480445,-0.0046936926,-0.045770027,-0.04861311,-0.03748518,0.036765743,-0.041323174,0.075693786,0.014818953,-0.01008154,-0.012670898,0.040125743,-0.004626843,-0.07947728,0.06306073,-0.0073387697,-0.0043610106,0.08488903,0.023190647,-0.023866309,0.0022489987,-0.012721063,0.010315421,-0.022096086,0.0057646954,0.13753724,0.09671739,-0.04227452,-0.086485185,0.032431677,0.08018074,0.014946491,-0.049225982,0.085027546,0.045064572,0.019935168,-0.155422,1.7552377e-33,0.03554351,0.06902827,-0.013128399,-0.0014712699,-0.010812439,-0.001357142,-0.10479618,-0.03869611,-0.041218586,-0.016746601,-0.09097717,-0.052399855,0.02122369,-0.018503426,0.00438153,-0.05960124,-0.020202665,0.0031609365,0.035930123,0.03979733,0.014022191,0.08664595,-0.026997264,0.034320522,0.08351716,0.064953044,0.0014554908,-0.0006819281,0.05502457,-0.027878629,0.075634815,-0.09464118,-0.0912638,-0.017793708,0.09170033,-0.05333019,-0.004348415,-0.005483477,0.071042016,0.06682296,0.00171367,0.06463655,0.004479834,0.01798225,0.08119114,-0.0822386,-0.054731656,0.1445651,0.011000932,0.07983861,0.0172551,-0.015213141,0.08837947,-0.00044584202,-0.06403724,0.03185152,-0.007867213,-0.009865427,-0.0021047227,0.05340215,0.033148386,0.040529978,-0.0343963,0.045444727,0.006220876,0.024925772,-0.0041631153,-0.01978695,0.049422327,0.06058998,-0.11058298,0.005198527,0.016625963,0.026922915,0.029693678,-0.05141205,-0.071848854,-0.012737953,0.043646153,1.9756221e-06,-0.031882513,-0.0034612499,0.019393936,-0.023570165,-0.081322856,-0.019600056,-0.057741392,-0.05090813,-0.015514588,-0.032379508,0.051808476,-0.05310727,-0.11912362,0.0027594315,0.006826814,-2.5107342e-33,0.10151861,-0.11071157,0.09443192,-0.04226019,-0.025065476,0.033135436,-0.07028317,-0.018660855,-0.019463405,-0.0053164223,0.044322554,0.001964405,-0.018111758,-0.038691327,0.021854496,0.028832799,-0.01758713,0.059921645,-0.037205905,0.010345995,0.005045426,0.12969396,0.039398104,-0.050480075,0.052592434,0.021216571,-0.041074045,0.046682864,0.114558905,0.024609568,-0.019161236,-0.054586325,-0.0066273483,-0.09398148,-0.040676076,0.0675169,0.016105734,0.00092148484,0.048511174,0.036067523,0.015047095,-0.034792922,0.0074866954,0.042063802,-0.039754577,0.03861679,-0.054707192,0.020004144,-0.021002743,-0.09799595,-0.00013543482,0.025144221,-0.01673783,0.02293722,0.026809156,0.01726351,0.005155179,0.015661493,-0.03249772,-0.015362521,-0.008476801,-0.044375133,0.06213104,-0.014512039,0.006413735,0.048595984,-0.023323506,0.037663076,0.042224627,0.01225322,0.08195643,0.001351054,-0.035013743,-0.021434914,-0.025312379,-0.006122942,-0.09061887,-0.016274435,-0.005362074,0.062743284,-0.043752085,-0.004275222,0.007729679,0.0049017607,-0.03221056,-0.11896749,0.033145137,0.06834327,-0.02905314,-0.02576061,-0.013415689,0.013245934,-0.010047393,0.0801583,-0.02156893,-3.7221348e-08,-0.008777862,-0.048938762,0.060341004,-0.048839018,0.03722128,0.014932353,-0.023385184,-0.019466767,-0.0010096106,0.021408884,-0.033780064,0.09753207,0.00965109,-0.06297407,0.03850991,0.03716683,-0.03022413,0.029492786,-0.013911486,0.014115992,-0.028037218,-0.012723196,-0.17413421,0.010944305,0.0146935135,-0.038117092,0.015161049,0.012474808,0.0050710235,0.0104632685,-0.011509906,0.02038032,-0.005549445,-0.060546197,-0.14361738,-0.041547153,-0.06225282,-0.048669413,-0.024803689,-0.0060388995,0.097156376,-0.04999072,-0.066818476,0.04422858,0.003404144,0.035611313,0.009517599,-0.03772643,-0.009748007,-0.0062252213,0.09551404,0.002555412,-0.009239363,0.00026753754,-0.12954953,0.08122093,0.02459932,-0.05813239,0.01233179,0.010067635,-0.045821194,0.017446484,0.19677784,-0.036099605 +1.14.99.61,Isolated from the bacterium Streptomyces melanosporofaciens M1614-43f2. Involved in the biosynthesis of cyclooctatin.,384,1.0,-0.07755635,-0.002182874,-0.14656244,0.03646695,-0.054996036,0.087984934,-0.070333466,0.061491866,0.036829248,-0.048029594,-0.009592695,-0.08475516,-0.011690083,0.027783543,-0.10510498,-0.015077811,-0.0119192,-0.004745347,0.061882608,-0.007841033,0.069021955,0.097531594,0.024953917,0.012383215,0.05563791,0.03997715,-0.04234385,0.02543732,-0.00528402,-0.011188742,0.04981786,0.012927868,0.08581157,-0.055147424,0.1519754,0.0945441,-0.052930962,-0.04024193,0.11843953,-0.019933758,-0.012367989,0.016068561,0.02979737,0.03515662,-0.018723356,0.041299857,0.057332303,0.062570505,0.04965884,-0.031323038,-0.0077012936,-0.026657525,-0.035558876,0.06406041,0.102099486,0.020382624,-0.050170336,-0.018776476,0.029980212,-0.03605322,0.07884585,-0.03627936,-0.025563551,-0.0008462475,-0.10674012,-0.00021953415,-0.0069887764,-0.08456261,0.04390427,0.013634722,-0.068519436,0.024231164,0.035852168,0.01062106,-0.029848365,0.11067928,0.04878691,-0.06932446,-0.089760475,-0.009581019,0.11398606,-0.015817335,0.03776968,0.05600446,0.013982284,-0.07583727,0.046456102,0.03769452,-0.0048595644,0.0568887,0.021270227,0.07339608,0.035863817,-0.09067473,-0.08231374,-0.0017270835,-0.070621245,0.045924667,0.024895899,0.032298625,0.028846357,0.008790988,0.082095385,-0.023825731,0.00069748465,0.03453851,-0.070621714,0.05723352,0.07678227,-0.00014974755,0.0101546105,0.029390207,-0.0624879,-0.044850342,0.024321817,0.034921926,0.07399054,-0.033201393,-0.06632422,0.012681737,0.009058985,-0.048844207,0.06480543,0.017925689,-0.04131356,-0.0002823659,-0.14542155,1.8768509e-33,0.042436697,-0.005103608,0.08378562,-0.066879615,0.067464784,-0.06605358,-0.021227367,-0.07743858,0.02246363,-0.06661406,-0.06321645,-0.050901398,0.047297586,-0.0173927,-0.050035417,-0.0097166095,0.024833964,-0.012261199,0.032666415,-0.049725275,0.0040181335,0.044034693,-0.0241641,-0.05684014,0.019241806,0.025534319,-0.003254234,0.023936007,0.0881071,-0.024423616,-0.033912644,-0.07508477,-0.09147184,-0.02726134,0.11515217,-0.09233652,-0.065998405,-0.11551681,0.08659808,0.007879349,-0.014230647,-0.013532302,0.052406438,0.012253553,0.07201964,-0.0008620914,-0.05099268,0.047468793,0.05635055,0.06282989,0.044892985,-0.065993056,0.03984631,-0.018297067,-0.092559785,0.007304296,-0.010499526,0.04754126,0.045957364,0.06663451,-0.01932319,0.019496828,-0.014562109,0.010182439,0.054144263,-0.009927894,-0.03934439,0.03445064,-0.09522527,0.026377648,-0.017615877,-0.041494824,0.06764732,-0.037129663,0.029699419,0.012190554,-0.04075056,-0.0020420912,-0.004161305,0.02941142,-0.023998093,0.01765143,-0.07150305,-0.08592425,-0.083069585,0.07777784,-0.014446164,-0.03949076,0.04143526,0.06949964,-0.07025474,-0.11073151,-0.073480554,0.03441016,-0.042122602,-3.3923816e-33,0.08307743,0.008804983,0.059304584,-0.035446115,-0.03217543,0.056622475,-0.037206993,0.0022820376,-0.068068855,-0.0027368488,0.01090942,0.023954075,0.035845216,-0.010484912,-0.025241818,-0.048561096,0.059494145,0.09953219,-0.043833576,0.04839779,-0.0019926913,-0.0030980175,-0.025412442,-0.020609844,0.032523498,0.001998404,0.011202788,0.039169274,0.0025533536,0.041917793,-0.024682524,0.013963816,-0.05262807,-0.092543304,-0.04947922,0.015195554,-0.032307018,-0.046574004,0.06263031,-0.019984707,-0.0012858143,0.026689705,-0.013657069,0.051233526,0.04047982,0.06398957,-0.04186503,0.018695528,0.008668982,0.010831466,-0.029817546,0.06230172,-0.058216,0.025486799,-0.034032162,0.0138299605,0.044104356,0.057133485,0.060635254,-0.0052371235,0.0051876092,-0.06403933,0.009618952,-0.03360724,0.110822916,0.08544477,0.0058038714,0.042473502,0.04283663,0.0026287327,0.009175579,-0.009769264,0.018058768,0.047521863,-0.029584246,0.05967712,-0.019554706,-0.05411343,-0.03320542,0.052705996,0.09254121,-0.041430835,0.03974344,-0.004513661,-0.034707546,-0.078033276,0.13204467,-0.020875156,-0.031196939,-0.010878803,-0.02549786,0.019586181,-0.013070951,0.07032629,-0.024081558,-2.572283e-08,0.031396102,-0.04103806,0.04462925,-0.07933599,0.022637162,-0.026878785,-0.056829385,-0.04030924,-0.027669752,-0.03199138,-0.037167586,-0.06923979,0.0023259015,0.006718361,-0.023056021,0.006187833,-0.06056367,-0.0578677,0.016142339,0.029594814,-0.08629549,0.00089888583,-0.053203527,0.06834067,0.03207504,-0.099479705,0.045917466,0.04738806,-0.019238476,0.049116913,0.053179618,0.023103677,-0.0415529,0.008822914,-0.05206313,-0.0565178,-0.106387146,-0.04399757,-0.0051901797,-0.015019487,-0.016288875,-0.002792952,-0.02620813,0.06496186,-0.09957591,0.0036269873,-0.012569997,0.0055186474,-0.047218114,0.002904335,0.037527688,-0.0036955012,-0.019632336,-0.03099472,-0.039406132,-0.010853449,0.06003217,-0.03506146,-0.056402393,-0.012395378,-0.030573057,-0.07912818,0.13868433,-0.002215967 +1.14.99.62,Isolated from the bacterium Streptomyces melanosporofaciens M1614-43f2.,384,1.0,-0.015386227,0.0017077014,-0.14764728,0.016270956,-0.0084635,0.07370771,-0.053847764,0.03460672,0.048677772,-0.059984848,0.033625714,-0.05186328,-0.04040034,0.06660729,-0.082488626,-0.010636474,-0.017481009,-0.034107894,0.031077262,0.035958625,0.03446548,0.09066803,-0.0019874463,0.0017012842,0.029858733,0.056351054,-0.004288051,0.01559481,-0.018004924,-0.057336662,0.046695944,-0.030174399,0.10177515,-0.039893545,0.15880269,0.043181404,-0.0172244,-0.043311898,0.11811343,0.00070518366,-0.043208223,0.015542276,0.06511782,0.026916128,-0.018829633,0.060871836,0.031028485,0.08422817,0.086101055,-0.01921145,-0.01895849,-0.021716755,-0.04399553,0.08236109,0.07541094,-0.006981877,0.005140797,-0.025226157,-0.00039768987,0.007696719,0.089636795,-0.054690592,0.017902857,-0.045692448,-0.095655054,0.0176795,0.0035516212,-0.06515762,0.09372114,-0.009092271,-0.032181207,0.019171115,0.046559375,0.029975327,-0.02266468,0.09413236,0.04596471,-0.047974825,0.006530305,0.008521943,0.080899,-0.023545314,0.045542993,0.055906255,-0.0077747307,-0.09619762,0.05321677,0.04267752,0.028191274,0.024272539,-0.007675973,0.051010817,0.016941626,-0.09817486,-0.07448986,0.007642379,-0.06499013,0.03982455,0.012429187,0.05785268,-0.027017253,0.008722093,0.06214218,-0.01078491,-0.04098552,0.01624425,-0.06293774,0.04412575,0.07375096,-0.038944576,0.06763877,0.068637885,-0.045597658,-0.035983294,0.03644262,-0.024791256,0.117661715,-0.062095918,-0.02821131,-0.0071082064,-0.0095459735,-0.02769063,0.08813224,-0.027992984,-0.022299457,0.01028589,-0.10908615,2.7303253e-33,0.028308239,0.0072100516,0.08493069,-0.061322153,0.06961725,-0.07207848,-0.022315368,-0.057432022,0.0094425725,-0.048711766,-0.06821688,-0.06780075,0.027766759,-0.029746689,-0.020499317,-0.020126978,0.050390046,0.01163367,0.013031579,-0.057781126,-0.018343909,0.048086733,0.022698833,-0.07613794,0.04291888,0.017707357,-0.026880203,-0.0056000226,0.117203705,-0.014554581,0.042452246,-0.0509052,-0.08717924,0.0050596762,0.065097906,-0.08334332,-0.09810287,-0.1031725,0.07112528,-0.021786574,0.024365965,0.054570362,0.058225363,0.058396205,0.04667209,-0.025104819,-0.055616178,0.041694567,0.074751586,0.051917497,-0.01369749,-0.041858353,0.03762036,-0.05481372,-0.056914456,-0.027899295,0.0010696321,0.051469427,0.07078233,0.04899369,0.0030892675,0.07271981,-0.02505776,0.010773746,0.095686205,-0.020601379,-0.045543045,0.029368771,-0.029884575,0.011024958,-0.008498523,-0.0040730755,0.050503165,-0.051858455,0.002836203,-0.02148022,-0.01714067,-0.025321329,-0.0071734805,0.016206194,-0.046314716,-0.014043421,-0.03387353,-0.059360538,-0.16401331,0.12751156,-0.036455624,-0.057724696,0.073433876,0.045835696,-0.04768546,-0.027492687,-0.11603306,0.0015338913,-0.0048999325,-3.23718e-33,0.11772967,-0.03831517,0.019598538,-0.01004298,-0.06539754,0.06747906,-0.07893828,0.022513852,-0.06605536,0.037193947,0.048438285,0.012698441,0.04238151,-0.06336689,0.0016713126,-0.010817002,0.08416674,0.06598939,-0.042527273,0.03929152,0.00825943,0.05133657,-0.027490005,-0.016001645,0.009260256,-0.025363743,0.01603094,0.007999439,-0.0057235486,0.016769428,0.025792016,0.0047436943,-0.024812236,-0.09914767,-0.06852991,-0.031415284,-0.015187523,-0.07072315,0.058865946,-0.0175394,0.037797585,0.047700208,-0.00898149,0.06492906,-0.002406637,0.06717207,-0.018177774,0.04505067,0.047933944,0.0026123612,-0.0593251,-0.009565411,-0.08415464,-0.026700802,-0.015426405,-0.04821109,-0.010844432,0.0060442253,-0.026338443,-0.0067686094,0.02169804,-0.10012767,-0.029505083,-0.02342075,0.11784144,0.08246454,-0.054706488,0.027361514,0.06509337,-0.025613448,-0.010375176,-0.018471181,0.016594313,0.04887743,-0.0252048,0.031852312,-0.019057576,-0.044127233,-0.006848304,0.029062374,0.10865024,-0.08516977,0.020611284,0.0025445283,0.013063041,-0.055025946,0.097762264,-0.036886703,-0.064357,0.013032786,-0.046774767,0.026129792,-0.035753023,0.04623509,-0.031361766,-2.3181638e-08,0.07185291,-0.03604467,0.061806764,-0.03842315,0.007999659,0.001015282,-0.04385831,-0.014320921,0.010983181,0.024451004,-0.050598834,-0.08682832,0.0063620573,-0.04967653,-0.03428313,-0.011883923,-0.06664528,-0.04516679,-0.014875365,0.026934225,-0.07437507,-0.011571601,-0.00018473639,0.029424373,0.03187196,-0.045324247,0.060644682,0.022139756,0.019624934,0.046676446,0.019799968,-0.0036809654,-0.049594715,0.008016708,-0.031043474,-0.026004618,-0.077604435,-0.025419943,-0.011365484,0.019477256,0.023021236,-0.005163439,-0.071032785,0.062375374,-0.1309167,0.03019628,-0.03123083,-0.030585213,-0.10924168,-0.021614902,0.08053582,0.0069173034,0.030300325,0.073530115,-0.102807716,0.012288326,0.01771656,-0.04698144,-0.05172471,-0.0034030788,0.018455429,-0.052849818,0.10044075,0.008669667 +1.14.99.63,"The enzyme, studied from algae, plants, fungi, and bacteria, adds an oxo group at position 4 of a carotenoid beta ring. It is involved in the biosynthesis of carotenoids such as astaxanthin and flexixanthin. The enzyme does not act on beta rings that are hydroxylated at position 3, such as in zeaxanthin (cf. EC 1.14.99.64, zeaxanthin 4-ketolase). The enzyme from the yeast Xanthophyllomyces dendrorhous is bifuntional and also catalyses the activity of EC 1.14.15.24, beta-carotene 3-hydroxylase.",384,1.0,-0.045693137,-0.036681626,-0.10330877,-0.015150061,0.06807487,0.014771384,-0.05633549,0.023049375,0.04293689,-0.050798222,0.04532759,-0.046312775,-0.0410271,-0.007957468,-0.04382778,0.044455267,-0.07734438,0.0005691855,0.0024249197,-0.059071794,0.074981615,0.0257211,-0.005686011,0.033133592,0.067148395,-0.024475133,0.015725281,-0.015481649,-0.047643833,-0.056683216,-0.045600902,0.008120797,0.06932213,-0.04259072,0.018421333,0.059169244,-0.025962044,-0.11205189,-0.02332729,0.050687563,0.040925488,-0.012635565,-0.008073971,-0.024499685,-0.037925243,0.027691554,-0.014068708,0.053300735,0.04597671,-0.017405646,-0.064119816,-0.07871919,-0.024480492,0.00049097574,-0.019074049,-0.002350387,-0.027347906,-0.034789566,0.0115193,0.06619485,0.09507684,-0.014757966,0.0626706,0.029286083,0.009080871,-0.034463096,-0.033559855,-0.08918782,-0.044883836,-0.080681846,-0.047045786,-0.04494797,0.027455335,-0.039477024,-0.010847008,-0.015663989,0.01264376,-0.080297045,0.0019050703,-0.04714952,0.055320967,0.021493586,0.04285609,0.04740599,0.023884423,-0.011449982,-0.038102444,0.019241406,-0.02227015,0.06667187,0.02749472,0.025250467,-0.055363517,0.071229406,-0.018121857,0.048007477,0.13369751,-0.033944562,0.0073921634,-0.051113527,-0.010691084,0.105927005,-0.0007065693,-0.06744837,-0.0042773597,0.043068673,0.025188025,0.11493567,-0.03225696,0.02600428,-0.0038004217,-0.028077792,0.058512505,-0.032977067,-0.05992273,0.066612765,-0.009679621,-0.023848293,-0.10818106,0.0030259802,0.038898867,0.004645725,0.0048710126,0.04510262,0.004640119,0.08315376,-0.13331945,3.3205166e-33,0.03677003,0.082510605,-0.06515102,-0.0039206585,-0.016703393,-0.062699325,-0.059537753,0.014704329,-0.027286394,-0.05971524,-0.067812696,-0.02393575,0.026358917,0.03427923,-0.003984554,0.0011739606,-0.008110647,0.02516688,-0.00031504812,0.0672521,0.027669514,-0.008413895,-0.12306513,0.027812483,-0.001650686,0.062156316,-0.040920563,-0.007600487,0.028759396,-0.0051488983,0.029532492,-0.053705968,-0.096699685,0.015134762,0.13594653,0.020761622,-0.048830036,-0.01544185,-0.10030747,0.053104524,-0.0003155928,0.049125757,-0.03589499,-0.04240521,0.02233893,-0.013934053,-0.011381362,0.06371755,0.11182376,0.09791761,0.01935872,0.016251039,0.10231053,-0.0077274907,0.0048993668,0.06709488,-0.07883009,0.018433008,0.005415478,-0.004970083,-0.08599134,0.059126843,-0.039143045,0.022855042,-0.06250138,0.023013055,-0.056783743,-0.07436296,-0.013657236,0.012053436,-0.06897611,0.0083808685,0.07148141,0.05167905,0.015508494,-0.00848061,-0.022663742,-0.030572621,0.0037303774,-0.04779211,0.0034711116,0.0077776713,0.052274045,-0.11139458,0.009953808,0.041269712,0.039120313,0.0062731104,0.040317208,0.037289307,0.025884075,-0.08286919,-0.024306804,-0.015592165,0.037011065,-4.0618928e-33,0.123457894,-0.10096285,0.03204591,-0.06977919,-0.0078114844,0.081578225,-0.056813348,-0.108702496,-0.021224704,-0.039274186,0.013467399,0.08876159,0.004930199,-0.066245236,0.055303037,-0.0076939547,0.020629566,0.07085742,-0.031731915,-0.022395406,0.04199874,0.1054506,-0.0026729782,0.022686444,0.043541,0.0040142257,-0.010078731,0.007096734,0.07378169,-0.013898915,-0.01928673,-0.016441075,-0.02624404,0.008060324,0.004978652,0.08465265,-0.12921357,0.031559054,0.045782883,0.10910179,-0.039883483,-0.0036280472,-0.035344034,0.027275952,0.062573805,0.10412887,-0.019022517,-0.011577228,-0.0011885964,-0.0022533461,0.045663256,-0.015279056,-0.02300635,0.015881266,0.07453667,0.048186734,0.03874319,0.07750985,-0.021179162,-0.04479882,-0.00063181267,-0.059266966,0.07076558,-0.06723946,-0.0050748233,0.018560594,0.0106805395,0.00038428808,0.056559723,0.044673525,0.04234468,0.016344102,0.016740337,0.03835201,-0.025201615,-0.04430839,-0.09628503,-0.068973035,-0.07502081,-0.05963006,0.018672837,0.08717466,0.06955512,-0.020120492,-0.03183293,-0.03549119,0.039073586,0.11082971,-0.07077019,-0.035061903,-0.0037885862,-0.031202575,-0.05439679,0.042699814,0.118400685,-4.4279883e-08,0.034470245,0.051334474,0.034561697,-0.06652111,0.029441586,-0.04059282,0.03140646,-0.011366897,0.05590656,-0.025928218,-0.011851277,0.08904676,0.06114018,-0.00010450556,0.023505833,-0.06881612,0.048077177,-0.011598124,-0.03326288,0.05466318,-0.028699767,0.017576715,-0.14783286,0.030503556,-0.008274818,-0.09700262,0.04998507,0.022009458,-0.022614712,-0.0019792092,0.00056465494,0.05301776,0.021934714,-0.030394044,-0.08552778,0.023791768,-0.024366159,0.016989741,-0.014990863,-0.008205018,0.028479015,-0.13195364,-0.018833492,0.010540973,-0.07718949,0.01011164,0.0032887864,-0.020359153,0.013634214,0.02347433,0.023943849,-0.03389101,-0.058473255,-0.043803677,-0.07572155,0.056519665,0.01751762,-0.023994988,-0.024010198,-0.058461886,-0.046505027,0.02041746,0.16646393,-0.075432986 +1.14.99.64,"The enzyme has a similar activity to that of EC 1.14.99.63, beta-carotene 4-ketolase, but unlike that enzyme is able to also act on zeaxanthin.",384,0.99999994,-0.033493772,-0.01265509,-0.069226585,0.011434588,0.03513489,0.01834397,-0.026364965,0.045819573,0.04939194,-0.019044794,0.038028963,-0.044491347,-0.007154818,0.066967495,-0.011065031,0.008037227,-0.0023156467,-0.07404454,0.0017857729,-0.08346181,0.013319971,-0.02133855,0.04673116,-0.021849552,0.046068706,-0.01835647,0.043767788,-0.0070340266,0.0122230835,-0.028119303,-0.014008853,-0.038616475,-0.005335684,-0.005183685,0.0076575615,0.038385976,-0.108847216,-0.11909732,-0.033680875,0.029281577,0.08565388,0.010585215,-0.05961912,-0.0788068,-0.02159909,-0.03743197,-0.059789427,0.008512228,-0.026761625,0.020496855,-0.07400858,-0.100605495,0.029549517,-0.0013293134,0.0009339613,0.009240288,-0.10041457,-0.007991488,0.027587606,0.11065621,0.06338033,-0.005993231,0.045708053,-0.043971043,0.007472703,-0.044058755,-0.0136708515,-0.10019067,-0.030275803,-0.08591093,-0.061170697,-0.045194056,0.033573236,0.011527842,0.027614659,-0.05989742,-0.029494207,-0.011537216,0.029726092,-0.036231443,0.03970727,-0.062110916,0.03397974,0.004060608,0.017053856,0.017106261,0.018874696,0.032491222,0.048011705,0.0069527226,0.02906349,-0.046248153,-0.07518663,0.027082074,-0.04017669,0.0042253565,0.01405386,-0.04032565,-0.008684066,-0.03163634,0.01565965,0.05610676,-0.06083085,-0.04448491,-0.066543676,0.04743535,0.06928986,0.10816238,-0.028944666,-0.012528933,0.0028096784,-0.03284217,0.1194601,-0.014847929,-0.05548735,0.09679892,-0.007667189,-0.054059803,-0.060479604,0.09773103,0.07291425,-0.02560325,0.10362481,0.0625625,0.0028599333,0.09006046,-0.11914679,-1.6668475e-33,0.044473257,0.05857005,0.022297872,-0.06791391,0.0114995595,-0.01094034,-0.055148724,0.02252797,-0.04963159,-0.12464683,-0.04432384,-0.038475957,0.08136778,0.07309776,-0.009438919,0.025208786,-0.017248305,-0.016107172,0.027680878,-0.004419056,0.061852332,0.0034880447,-0.06433343,0.061563093,0.01684982,0.06374152,-0.052758817,0.03793295,0.0005847644,0.012319477,0.014371147,-0.060140662,-0.09160409,0.035519455,0.1053297,0.082830444,-0.014876302,-0.048645332,-0.05747255,0.0036991131,-0.040582176,0.049045168,0.02456513,-0.07886983,-0.027983684,0.008007109,-0.029780157,0.09600129,0.09596313,0.01719797,0.087738805,-0.00074175285,0.053919025,-0.041629814,-0.03480708,0.14941841,-0.017218012,-0.00017635633,0.07753474,-0.004766634,-0.024792792,0.008182261,-0.040832512,0.024577744,-0.040135942,0.0730705,-0.13812357,-0.07604318,-0.05617853,0.10968863,-0.05938134,0.03286607,0.06692707,-0.010803046,0.015495505,-0.037394267,-0.013431327,-0.024005339,-0.023700356,-0.006032896,-0.02643584,-0.019384457,0.0358446,-0.05723566,-0.008885687,-0.026425948,-0.06470354,-0.019708976,0.100822136,0.03973845,0.033042282,-0.05519448,-0.09840971,0.02189015,-0.031002592,4.6783977e-34,0.04735166,-0.008655223,0.04018427,0.01348436,0.03494623,0.07711391,0.025474837,-0.0928389,0.008182395,-0.038038526,0.07766676,0.05327298,0.04600043,-0.024556875,0.031019717,0.06970321,-0.024721365,0.043303292,0.033981975,0.0014210287,-0.07747075,0.044819098,-0.056113437,0.0027839285,0.04258836,0.019610241,0.0011588585,0.012114085,0.07569028,-0.038510483,-0.055944186,-0.059170697,-0.04483248,-0.043120336,-0.00082856766,0.09031744,-0.040936675,-0.028921451,0.01059747,0.029794652,-0.042187944,-0.022426432,0.0067337053,0.043845575,0.02656656,0.076736465,0.01701507,-0.042288247,-0.04681187,-0.030755414,0.025500517,0.00974093,-0.058330636,0.03389928,0.0264422,0.04191029,0.042296994,0.057035822,-0.06679425,-0.024757417,0.025167273,-0.039928406,0.04427173,-0.008336569,0.042435125,-0.021203566,-0.016306039,0.04824238,0.06320533,-0.01415557,0.07355262,-0.041775268,0.020440303,0.05782328,-0.007923131,-0.0054473886,-0.090816304,-0.041048866,-0.02139806,-0.072971985,0.03921078,0.054204162,0.019555619,-0.045697812,-0.025378622,0.046244424,-0.006763423,0.14783725,0.0205018,-0.028143585,-0.03350727,-0.0030394064,-0.046016805,0.027326893,0.07359959,-3.1911807e-08,-0.0005039525,-0.018762609,0.0030057847,-0.034927472,0.010990812,-0.05306125,0.026971973,0.003888921,0.015339367,-0.019646162,-0.043505315,0.09450879,0.028964028,0.023193056,-0.021475527,-0.02403606,0.0005949263,-0.009425281,-0.010799001,0.042482495,-0.08767193,0.030032903,-0.096753545,0.028308133,-0.028442798,-0.09800261,-0.011379972,0.10729151,-0.019420035,-0.04384805,-0.0131425,0.054533288,0.07947208,-0.054359466,-0.12986198,0.02986913,-0.018458642,0.06578633,-0.035281654,0.07024001,0.061868224,-0.08311421,0.0007082133,-0.026928177,-0.09656885,0.039567627,0.010425055,-0.088360995,0.04954525,0.018295258,0.009935534,-0.030532276,-0.040275984,0.005837804,-0.013070277,0.015494302,-0.027715812,-0.0402347,0.035773087,-0.11446132,0.07130088,0.04159796,0.15884851,0.017111318 +1.21.98.4,"This bacterial enzyme, which is a member of the radical SAM protein family, catalyses the formation of a C-C bond between C-4 of glutamate and C-3 of tyrosine residues of the PqqA protein (which are separated by three amino acid residues). This is the first enzymic step in the biosynthesis of the bacterial enzyme cofactor pyrroloquinoline quinone (PQQ). The reaction is dependent on the presence of a reductant (flavodoxin) and the accessory protein PqqD.",384,1.0,-0.1113471,-0.030296298,-0.10912193,-0.034045804,-0.02351789,0.09933292,0.00087322685,0.06369784,0.058096766,0.021703122,0.06377928,-0.026039815,0.007132775,0.071709596,-0.030852757,0.06690026,-0.105454646,-0.013898401,-0.009285097,-0.06869044,-0.018877242,0.009072918,-0.00733376,-0.020824652,0.031049034,0.052480496,0.076952234,0.0037040582,-0.008714679,0.009292715,0.012830768,-0.013398713,0.033175316,-0.044381786,0.042568326,0.099289335,-0.043450736,-0.047579445,0.09788902,-0.010452483,0.0440169,0.05420255,0.064377055,-0.0033872086,0.09284524,0.060730282,0.04756585,0.108671345,0.061236344,-0.033319555,-0.05156062,-0.04133209,-0.0795323,0.042178847,0.0730465,0.07153431,-0.024656529,-0.025809065,-0.041926872,0.022092495,0.013203818,0.047356248,0.008867715,-0.00701116,0.0005279736,-0.038759727,0.013002082,-0.053758085,0.059722766,-0.06300436,-0.07531605,-0.07013014,-0.019637492,-0.01807018,-0.004232265,0.045912664,-0.03842701,-0.011166347,-0.034716703,-0.040328722,0.061402097,-0.047286045,0.0012700235,0.089308254,0.037835468,-0.04240603,-0.026792958,-0.04322557,0.06720073,0.034788545,0.04547941,0.0089608105,-0.050254144,-0.113634676,-0.033681706,0.042499017,-0.04682139,-0.015959691,0.0054215393,-0.027557882,0.03454892,-0.0014207109,-0.0036584856,-0.059657574,-0.04914492,0.0074135386,0.014856947,0.07830928,0.043952167,-0.038607854,-0.057442695,0.0026401132,0.057267103,-0.05592214,-0.008970165,0.089900225,0.11991294,0.026800472,-0.09327214,-0.0030160774,0.0031916935,0.01651342,0.04870917,0.00014067224,-0.045558777,-0.06486482,-0.08220143,2.7558734e-33,0.079185516,0.05379146,0.05058543,-0.042823493,0.06794814,-0.028111307,-0.046770725,-0.0056519774,-0.0680206,-0.029199729,-0.041647144,-0.11085516,0.0151508665,-0.033782825,-0.055992488,0.024091432,-0.14047028,-0.057033576,0.00015189785,-0.037028283,-0.01988572,0.029440999,-0.04257573,0.05093607,0.07033304,0.07252334,0.036447667,0.027482731,-0.022525074,-0.023599252,-0.027899053,0.0021137504,-0.14965852,-0.05679347,-0.032102518,-0.018668987,-0.08051246,-0.08087138,-0.05471904,0.043144632,-0.028329613,-0.033880975,-0.0028303454,-0.0014535188,-0.011658027,-0.07246106,-0.03552337,0.06931971,0.06331486,0.036995847,0.10196118,-0.04148411,0.08431422,0.06686446,-0.077154785,-0.0047956957,0.026208729,0.015764134,0.045975525,0.041754477,0.04811884,-0.00033650335,-0.09736209,0.011960417,-0.0022050922,-0.0020700314,0.0007304869,-0.055336986,0.009185724,0.11210759,0.033286393,-0.07135068,0.018999599,-0.03462162,-0.0064821485,-0.057795048,-0.09468558,0.009619244,0.030998338,-0.04561862,-0.06186883,-0.0044272062,0.07833279,0.008293409,-0.040535532,-0.037938654,0.023338152,-0.016044358,-0.016711786,0.0011111281,0.010234406,-0.029609302,-0.00083905895,0.05780725,0.043106686,-2.4937604e-33,0.020342425,-0.08774937,-0.021986684,-0.035464294,-0.06512288,-0.008676383,-0.0030959817,-0.009948061,0.040494673,-0.06912998,0.025309745,-0.038245905,0.039672766,0.018744426,0.045067262,-0.0052770167,-0.0049451333,0.08694216,0.00026446467,0.024203965,0.043679383,-0.014685122,0.03860723,0.018710457,0.03557217,0.010922329,0.033601977,0.048942953,0.030773055,0.11605619,-0.035884134,-0.033352006,-0.052309398,-0.071137816,-0.03438555,0.042324964,0.005810932,0.031868428,-0.018220054,0.01491934,0.076904505,0.013703485,0.009683423,0.06791759,-0.004802766,0.093835905,-0.03091336,-0.003944493,-0.06686939,-0.022167144,0.06620607,0.04803341,0.035194043,0.0020452642,-0.0059774937,0.045072027,-0.020102981,-0.00082687393,0.058623582,-0.04896285,-0.07978938,-0.09954164,0.0012647068,-0.023209544,0.06764455,0.05619155,0.05512559,0.104174584,0.07242819,-0.059716187,0.036777537,0.019043932,0.028948095,0.09614474,-0.063293874,0.016399916,-0.054871287,0.0060585644,0.09040487,0.0053159613,0.059226442,-0.05977413,-0.009630667,-0.018549835,-0.056492593,-0.0967386,0.042921767,0.11048452,0.021273067,0.023968184,-0.038348507,0.031077165,0.03461996,0.068749614,0.027743118,-3.7865345e-08,-0.00013205112,-0.07281685,0.011929171,0.01048089,0.06072213,0.07698422,-0.009767614,0.017486768,0.012802171,-0.015951987,0.021411758,0.004904137,-0.030728886,0.02508826,-0.0018152767,0.058391243,-0.0553702,-0.0043506366,-0.013588035,-0.044423155,-0.06161776,0.031815227,-0.09838155,-0.010320377,-0.012167466,-0.018392071,0.023324035,0.07617333,-0.06313866,0.007527092,-0.024046477,0.023353005,-0.0044246563,-0.018691875,-0.12817067,-0.003920264,-0.013496593,-0.03171224,0.03496232,-0.012777339,-0.04479981,-0.0042311233,-0.080651745,-0.0062981076,-0.039173238,0.015026322,-0.010301915,0.006252423,-0.03458524,0.010376655,0.09453052,-0.00654818,0.044091057,-0.054285042,-0.16113676,0.020019593,0.048039872,-0.04465278,-0.00089287997,-0.094241105,-0.013383969,0.01262795,0.1705698,0.029586216 +2.1.1.349,The enzyme is a dual-specificity methyltransferase that catalyses the last two steps of toxoflavin biosynthesis. Toxoflavin is a major virulence factor of several bacterial crop pathogens.,384,1.0,-0.056901295,-0.020818247,-0.14489344,-0.0048098117,0.071224205,0.118423656,-0.10161744,0.04214271,0.009816173,-0.021950373,0.0039254883,-0.06817766,-0.040114563,0.04227831,-0.074049935,0.057617053,-0.11241943,0.007664727,-0.02394264,-0.06800704,0.039365526,0.028614085,-0.0064119305,-0.031302165,0.022787027,0.015687147,-0.058034528,-0.055412345,0.035308782,0.017891025,-0.042839367,0.07164574,0.003507036,-0.059732143,0.008131149,0.12601295,0.054757986,-0.061442275,0.058843117,-0.051005922,0.033219375,0.0288707,-0.011385936,-0.04853444,-0.019140122,0.004658034,-0.000106377825,0.023493178,0.04832106,-0.0107241245,-0.02847396,-0.030466072,0.030174164,-0.03008231,0.092008114,-0.026080832,0.025305677,-0.03251595,-0.01458527,-0.0053024506,0.031207656,-0.079657555,-0.029255996,0.055488158,0.03746873,-0.09157011,-0.0029976382,-0.08530225,-0.07236932,-0.074573785,-0.07371521,-0.0664851,-0.04033506,0.09326602,0.018036533,0.03807539,0.027374526,-0.005755848,-0.005478235,-0.047691274,0.099788465,0.04876463,0.019253867,0.05597527,0.02758705,-0.054464824,-0.027381213,0.039238982,0.07285413,0.12022191,0.0026330864,-0.0036549575,0.081076056,-0.025478065,-0.034297094,0.022193227,0.05398474,-0.026210569,0.05301386,-0.016767984,-0.013324679,-0.05531927,-0.044950996,-0.047561727,0.0012593606,-0.032753747,-0.05039181,0.031992167,0.03211849,0.006647928,0.040423628,0.042928215,0.086751945,-0.013865705,-0.078827895,0.026692247,0.011669441,-0.032297585,-0.04099855,0.03879155,0.006431748,-0.02993761,0.024068866,0.124350496,0.0014672466,-0.061447296,-0.05310061,3.0469043e-33,0.052944478,0.023133432,-0.059976034,0.0038677948,-0.014453604,-0.06044556,0.007863085,0.033605438,-0.03562689,0.025355296,-0.046033625,-0.115415424,0.0070056207,0.050744247,-0.038627785,-0.058957618,0.017972881,-0.035353757,0.0148247,0.0334833,-0.057622332,0.04318367,-0.050459642,0.011777084,0.089477904,0.043954868,0.019973205,-0.036746666,0.014567793,-0.018741103,-0.010726239,-0.12922142,-0.07266405,0.020426774,0.0813232,-0.0010659347,0.0076340917,-0.024025805,-0.03720494,0.078057535,0.039548445,-0.0039073434,-0.04575917,-0.051899362,0.05929249,0.02868095,-0.05424691,0.007044384,0.02404766,0.019363854,0.058147755,-0.008311248,0.08988435,-0.037595794,-0.057046533,0.041795842,0.018986357,0.008910358,0.0013166487,0.042184584,-0.0669213,-0.037302457,-0.054221448,0.013061198,-0.061012425,-0.084112465,0.026549019,-0.085334525,-0.014034167,0.04245222,-0.076687716,-0.015181046,0.075667255,0.02012488,0.0164644,-0.0042737736,-0.027080107,0.006008708,0.09064173,-0.050859973,-0.04484302,0.079742484,0.03725993,-0.017074838,-0.13599469,0.008720437,-0.012888339,-0.057873297,-0.08484507,-0.015152155,0.05999778,-0.029371347,-0.009989608,0.010042087,0.042362478,-5.048502e-33,0.002351898,-0.046641827,-0.013944761,-0.100972444,-0.08043077,0.09008149,-0.011402221,-0.026383711,-0.0072217844,-0.006101125,0.05245007,-0.016677566,0.012212196,0.01259437,-0.00244075,0.08132943,0.050592545,0.092904136,-0.10419061,-0.07708771,-0.034719523,0.024376018,0.046490606,0.012318688,-0.042201564,0.062381085,-0.009219191,0.10439432,0.010961233,0.093230404,-0.034416292,-0.051809616,-0.031157326,-0.06196921,0.030112896,0.084548935,-0.016320165,-0.009427478,-0.028778218,0.034981966,-0.027351703,0.05473773,0.004165157,0.021941034,-0.013765078,0.077080004,-0.035519436,-0.010039614,0.05798211,-0.054944705,0.04686028,0.0403494,0.027489321,0.05684278,-0.039484777,-0.02232579,0.06472014,-0.042746834,-0.017972955,-0.046369523,-0.035889633,-0.03350681,0.060570825,0.059094008,0.034128454,0.09763513,-0.048201904,-0.044383936,0.0049699903,-0.06435263,0.039995708,0.008115629,0.023482531,0.07016235,-0.06754367,-0.061328858,-0.0012831851,-0.10532933,-0.0020989918,0.0060569667,0.0009447475,0.016436622,0.009934178,0.011608312,-0.027307378,-0.05589895,0.059038192,0.09038145,0.032347016,-0.00529513,-0.03574994,0.05173419,-0.063479014,0.008132229,0.08738362,-3.4328725e-08,-0.007588491,-0.13219343,0.0021344926,-0.07677697,-0.0020922043,0.041979305,-0.030759426,-0.015371519,0.06824809,-0.046317223,-0.013655403,0.041109033,-0.039452456,0.028345406,0.08479381,0.0074663907,-0.032817338,-0.012276236,-0.022845631,0.016708786,-0.039846644,0.014232555,-0.08569429,-0.033468373,0.04224836,-0.05991217,-0.045815103,0.095458426,0.09897762,0.00053700677,-0.031842325,0.045100283,-0.077354215,-0.0015844059,-0.11810695,0.07226559,0.008508241,-0.07897849,0.053814746,0.026325757,-0.002035803,0.013291821,-0.061347578,0.049717713,-0.04449483,0.012942123,-0.0013325035,0.051740315,0.048163157,-0.028850432,0.021356996,0.004706244,0.007650083,-0.03361471,-0.07604585,-0.044228617,-0.024771074,-0.019892143,0.06432289,-0.010927588,0.006675183,0.031474948,0.17135246,-0.0445879 +2.3.1.273,"The enzyme, characterized from mycobacteria, is involved in the biosynthesis of methylglucose lipopolysaccharide (MGLP). The enzyme can also act on 2-O-(alpha-D-glucopyranosyl)-D-glycerate, but with lower activity.",384,1.0,-0.058927137,-0.056842204,-0.07383323,0.02034125,-0.081109464,-0.042786177,0.0106217805,0.045848425,-0.025205323,0.0048636333,-0.014298063,0.0031477963,0.006117988,0.030714868,-0.015737927,0.048617654,0.05108158,-0.0171174,-0.023723243,0.02915627,0.12053275,0.055258032,-0.01859246,-0.059917316,0.036813565,0.030963946,0.04392099,-0.00844263,-0.010607038,-0.052675877,-0.019112498,-0.045804646,0.098275416,-0.05423842,0.12685993,0.07861232,-0.03102296,0.0025729837,0.076585695,0.004308888,0.045479942,-0.02282598,0.046526004,-0.007940495,-0.026625188,-0.004055654,-0.014814384,-0.0051382296,-0.025241425,0.028312316,-0.04525807,-0.07619852,-0.048112806,-0.0066550453,0.058520187,-0.0019957994,-0.034369797,-0.025200073,-0.006954212,0.008142844,0.024181472,0.00952954,-0.0018901585,0.062230706,-0.0070397444,-0.05780426,0.05376981,-0.077915885,0.007552355,-0.066036046,-0.06811148,-0.056878455,-0.06430571,0.061586376,-0.021493718,-0.04408268,0.038204014,-0.042621132,0.08694512,0.01141829,0.049678516,-0.029349774,0.009162609,0.040808164,0.006286168,-0.040083047,0.09837662,0.0002921104,0.041713476,0.04041462,0.044465557,-0.05478808,0.016119407,-0.014767029,-0.06164568,-0.012312465,0.019052299,-0.057800274,0.02254946,-0.009790314,-0.0016967382,-0.006271472,-0.009570736,-0.013074841,-0.07996703,0.053374536,-0.039222248,0.018137915,0.043342523,0.03572709,-0.002241952,0.046420638,0.029853653,0.045615923,-0.014512113,0.050300695,0.08459342,-0.043412566,-0.05174223,-0.025142305,-0.0038454987,-0.082037315,0.035534173,0.036169574,-0.08265266,0.08811704,-0.07356232,6.2189983e-34,0.04840354,-0.05002564,-0.017526448,-0.058728997,0.036561616,-0.034511425,-0.07100534,-0.0346208,-0.060210142,-0.003848574,-0.009273882,-0.10223557,0.0043468256,0.13358073,-0.06873963,0.10994359,-0.012599105,0.019286135,0.10075856,0.049864545,-0.014188982,0.08426492,0.034695815,-0.016745338,0.039947968,0.12265839,-0.051132273,-0.034240827,0.056962475,-0.007011003,0.065884374,-0.101652116,-0.075125486,0.027014878,0.04622236,-0.004525359,-0.041114107,-0.08972596,0.02597941,0.045741953,-0.048117798,-0.023643397,-0.026793242,-0.011662386,0.041493967,0.022484474,-0.067324534,0.009398114,-0.005872384,0.05312788,0.067024164,-0.027384534,0.022020048,0.02632653,-0.063067205,0.0074376627,-0.054483052,0.038964726,0.058264527,0.04993111,0.008204513,0.096732624,-0.0060208826,0.05311846,0.015593777,-0.05111672,-0.04120634,-0.00938501,-0.015251352,0.08396413,0.004383281,-0.06244626,0.0064552305,-0.0048695435,0.037489552,-0.06410431,-0.018457217,-0.021155283,0.001650829,-0.021219825,0.041314617,0.021376718,0.008611453,-0.058207035,-0.07708048,0.019379618,-0.071641885,-0.097059466,-0.035424132,-0.016506633,-0.03498285,-0.009511356,-0.05070425,0.09947667,-0.034956407,-3.9648547e-33,0.11469093,-0.10787848,0.14189357,-0.08452865,-0.04910732,0.0056557227,0.04633247,-0.00738648,0.04474362,0.02617908,0.054004148,0.013435044,-0.009735968,-0.014261577,0.03155804,-0.025879472,-0.0119984625,0.050143473,-0.08847309,-0.050501913,-0.0010807181,0.07395785,0.022473251,-0.015193395,0.06787167,-0.026956154,-0.019574909,0.06189332,0.032531694,0.032194592,0.010290155,0.048205152,-0.013492004,-0.14038685,-0.06336253,0.04533811,-0.08308939,-0.023147244,-0.021193203,0.002569619,-0.0037865315,0.08219156,0.062505305,0.006564693,-0.018470725,0.027250402,-0.07389738,-0.0026559916,0.048510294,-0.04152695,-0.041144665,-0.012063211,0.037927527,0.054039326,0.06694912,0.044960257,0.05190361,-0.028429281,-0.013247427,-0.060211398,-0.060499076,-0.059175696,0.05599593,-0.017950801,0.10485613,0.13362704,0.057950586,-0.023272058,0.04598891,0.033737935,0.041338038,-0.018566282,-0.036887947,0.019610973,-0.017877363,0.028866429,-0.100348465,-0.030101439,0.008823945,-0.0342938,0.015913552,0.02503153,0.013904193,-0.054739963,-0.034317072,-0.13933003,-0.025587708,0.15899158,0.048925392,0.057789933,-0.043941967,0.015311848,-0.05008454,-0.047996216,0.0072187954,-3.9368015e-08,-0.0058167893,-0.086418144,0.034209292,-0.06915474,0.02672608,0.041924722,-0.04994915,-0.016958956,0.08023679,-0.006055366,0.018806996,0.06607444,0.02135793,-0.039570153,0.0018576178,0.019803235,-0.06252192,-0.049261212,0.003716384,-0.03753287,-0.09244494,-0.04157288,-0.07654467,0.0755821,-0.0035890706,-0.09407455,0.021675019,0.10066419,-0.041824564,0.0058679087,-0.020930305,0.07146322,0.011986948,-0.05536791,-0.09266658,-0.0022485733,-0.036317844,-0.078044586,-0.021907382,-0.0017520072,0.04128878,-0.04128799,0.046489924,0.009654131,-0.036402337,0.009844028,-0.019386021,-0.027849292,-0.026496189,0.050919253,0.006092508,-0.022050695,-0.094067894,0.0019229593,-0.04425242,0.02885448,-0.035790715,-0.012183742,-0.015224453,-0.01906405,0.01894438,-0.0064677503,0.15055196,-0.08372687 +2.4.1.358,Isolated from strawberries (Fragaria X ananassa). Acts best on phloroisovalerophenone and phlorobutyrophenone but will also glycosylate many other phenolic compounds. A minor product of the reaction is the 5-O-beta-D-glucoside.,384,1.0,-0.06123404,-0.05057618,-0.06742875,-0.0027840787,0.10126873,0.059778523,-0.031235665,-0.02017777,0.008023049,0.012150933,0.10061117,0.011040222,-0.085341826,-0.0063460185,-0.03147751,0.11085706,0.048560865,0.022687761,-0.090985246,-0.020909855,0.03981099,0.0016905974,0.024576211,0.025939021,0.00085455005,-0.024120271,0.02532952,-0.019090248,-0.04205889,-0.10993532,-0.027728332,0.011463456,0.066603824,-0.037636448,-0.004597679,-0.0038677724,-0.024339605,-0.11347638,0.1455615,0.019075487,-0.066266745,-0.065737866,0.069394745,-0.03499486,-0.02776766,-0.06268729,-0.013467762,0.06144893,0.068426065,0.014022679,0.0010411127,-0.022390904,-0.034905456,0.00420088,-0.025207553,0.018671291,-0.027753323,-0.0007081591,0.01573319,0.074010044,0.05798922,0.0106605515,-0.027797699,-0.021767825,-0.118793845,-0.034431852,-0.018936198,-0.039252546,0.08794916,-0.046952065,-0.04366925,-0.058805805,0.0152994525,-0.026753759,0.013344567,0.0402509,0.008501431,-0.006501563,0.039822746,0.03416793,-0.0040101483,-0.021558259,0.08207356,0.056532856,-0.034059487,-0.006781102,-0.044980258,0.10783149,0.021178281,-0.0034325165,-0.024193706,0.0585584,-0.023758672,-0.002768417,-0.04634714,-0.009485781,0.061098676,-0.013428668,-0.0016298826,0.030510819,0.028987957,0.027828123,-0.025371037,-0.12784795,-0.0694086,0.038226523,-0.0016560137,-0.07162106,0.03030005,-0.011507671,-0.07135328,-0.017833073,-0.01049687,-0.0043734973,-0.08162475,0.0032681716,0.09701096,-0.027388139,-0.06841671,-0.034856252,0.065264754,0.031277332,0.1097039,0.03281804,-0.035329856,0.06661889,-0.06035894,5.292126e-33,0.06472884,0.04023746,-0.00268725,0.039535463,0.03227102,0.051101703,-0.021450456,-0.0148534505,-0.00718582,-0.046975728,-0.10623027,-0.033180274,-0.010280345,-0.024539616,-0.014339696,-0.006745186,0.00296946,-0.022811742,0.036973607,-0.04789023,0.014007889,0.10187184,-0.02308294,-0.011204127,-0.009549312,0.02692974,-0.034678757,-0.0016670035,0.073481806,0.011031978,0.059619565,-0.08166707,-0.054858714,-0.029326845,-0.0030753103,0.06815403,-0.13554645,-0.061448943,-0.0006804233,0.045835912,-0.010996028,0.054367196,0.031740688,0.027212244,0.014323735,0.036252473,-0.066308394,0.048225615,0.0831885,-0.028081736,-0.04937838,-0.04733103,0.03571514,0.040490936,-0.028030617,-0.025308082,-0.019472482,-0.012400948,0.02885234,0.05553823,-0.030842794,0.06603497,-0.014140257,-0.034210864,-0.0063070236,0.07707099,-0.08799931,-0.031960838,-0.049236305,0.030126618,0.06059148,-0.031855874,0.0741976,0.02224213,-0.020723842,-0.09219012,0.097236305,0.025840702,-0.060305245,-0.013357041,-0.018074542,-0.03206487,0.020854771,0.044183448,-0.090846434,0.03524633,-0.084316626,-0.03840392,0.037750594,0.05967613,-0.061662603,-0.027403064,-0.055810064,-0.043068144,-0.002408335,-4.6381543e-33,0.056610163,-0.07323245,0.01762059,-0.028662778,-0.0007646462,0.031456456,-0.050302435,-0.04716543,0.032719996,-0.007973404,-0.03125915,0.01134382,0.059892684,-0.040937603,-0.02546572,0.08728088,0.10679443,0.077245526,-0.03410893,0.033782993,-0.07065263,0.060536478,0.03901716,-0.0075946753,0.10060414,-0.032929286,-0.007678166,-0.025683833,0.014085625,0.025450462,0.013844991,0.008239638,-0.0033690291,-0.091646455,-0.00602501,0.033120424,-0.10541398,-0.07550048,-0.02998361,0.05644206,-0.01976689,0.017281974,0.0027296096,0.0411005,0.059996266,0.038958855,-0.13129134,-0.024414517,-0.06320515,0.059354555,-0.010927785,0.026183378,-0.024125382,-0.004851097,0.08498716,0.05592312,0.038330793,-0.012146299,-0.024639506,-0.035954665,0.0020995967,-0.024827287,-0.06550368,-0.011403317,0.12751782,0.15268475,-0.018128335,0.13260184,-0.0010551197,0.0106340805,0.07916921,-0.015093618,0.051353574,0.064946584,0.017620089,0.00050785183,-0.06262438,-0.0044992524,-0.034653958,0.048120264,0.044645973,-0.038020674,0.058440767,0.020747786,-0.0002028855,-0.07626351,0.044954907,0.07842084,0.028782148,0.050279297,-0.017977031,0.0063904733,-0.03261638,0.07677371,0.11198574,-3.592352e-08,0.04799292,-0.08716028,0.013774346,-0.018634742,-0.061575785,0.05481325,-0.07049416,-0.007993402,-0.015739467,0.03183539,-0.1008859,0.043332487,0.023814911,0.028906906,-0.042784873,0.0047998866,0.036055766,0.07720924,-0.022390138,0.047970522,-0.14476694,0.05946708,-0.011136659,0.012683992,-0.04348268,-0.042945035,0.036810357,-0.04565151,0.0317985,-0.043127052,0.046700075,0.030825518,-0.019609395,-0.026803473,-0.07207102,0.07695009,-0.002034656,0.012410629,-0.06319967,0.04132413,-0.09015686,-0.041539453,-0.0076781474,0.030642383,-0.040017113,-0.06655572,0.03721954,-0.031769797,-0.019009998,0.04949335,0.0045816274,0.024671113,0.055498295,-0.038957123,-0.05306824,-0.030616041,0.024968704,-0.0071140756,0.02510216,-0.05834595,-0.040462058,0.014444681,0.13738401,0.04250449 +2.5.1.147,"The enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 4.3.1.32, 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to initiate the reaction.",384,1.0,-0.094046526,-0.035787508,-0.13797022,0.053455736,0.046772737,0.034590464,-0.0931766,0.0757815,-0.041016545,0.0350734,-0.013479483,-0.03618713,-0.081628315,0.040046636,-0.01695555,0.06474756,-0.07488773,-0.0005567655,-0.06576054,-0.049472544,0.0220511,0.020986231,-0.043623235,0.01743888,-0.0013650884,-0.007050438,0.037717983,0.006105144,-0.033861816,-0.051761616,0.017954296,-0.031205546,0.13319083,-0.03288235,0.005864824,0.07438392,-0.044241738,-0.096605286,0.061457187,0.015386585,-0.013919041,0.044478573,0.008748589,0.010953245,-0.0110567445,-0.027517363,-0.026568543,0.056238852,0.11934988,-0.02674146,-0.07148681,0.025901955,-0.066250205,0.03195307,0.045143522,-0.009622068,0.01002068,-0.09291442,-0.014788883,0.030434512,0.053834483,-0.02878689,-0.020581635,-0.010506052,-0.04483115,0.035683617,0.07842093,-0.074548855,0.026189635,0.0020005032,-0.030057112,-0.038396835,0.005496282,0.020229682,-0.063990474,-0.034057975,-0.012435058,-0.020443343,0.0347041,-0.00670914,0.08937007,-0.00838361,0.072225876,0.037466876,0.016064014,-0.016234446,-0.04058741,-0.04517834,0.030356571,0.019148331,-0.013055105,0.030855566,-0.072247624,-0.052313387,-0.054372247,0.047418457,0.030849304,0.04770826,0.06440115,0.006267005,-0.03036286,0.017522668,-0.038033277,-0.0656556,-0.028021196,-0.0037806672,0.014004314,0.08517061,0.010399163,0.056325268,0.012410657,-0.014165267,0.046295036,-0.013755826,-0.01186028,0.05823507,0.017786711,-0.08376778,-0.061544564,0.040442843,0.075692356,0.005673103,0.077947125,0.05824764,-0.066425815,-0.019811325,-0.11829767,6.5463524e-34,0.08188643,0.055989675,-0.020946529,0.02882228,0.015549229,-0.035991523,-0.09535412,0.068396896,0.028729878,-0.0036626002,-0.060024377,0.0036544078,0.05808324,-0.052651353,-0.06133738,-0.081049375,-0.00198986,-0.0090990765,-0.0033400904,0.05249298,0.01820562,0.016543353,-0.039354414,0.018810172,0.0066843345,0.12040523,-0.026169786,0.0039719283,0.041649383,-0.0011695932,-0.027289385,-0.12397581,-0.107721165,0.021707272,0.061218686,-0.038412444,-0.062002726,-0.036742996,-0.022402385,0.052477382,0.0671683,-0.017004877,-0.05202276,-0.005224449,0.09074346,-0.026202064,-0.102283604,0.063878536,0.111945674,0.10141124,0.031669863,-0.011831155,0.070844255,-0.008681138,-0.029425463,-0.055892255,-0.025694693,0.014889369,0.088395,0.06544912,-0.014116299,0.017645082,-0.04290341,0.028573891,-0.019870019,0.0026489792,-0.0060291057,-0.019884497,0.012299321,0.010007913,0.0069136578,0.023985602,0.055873547,0.060093947,0.054465488,-0.023350796,-0.002655719,0.003662436,0.029107593,0.010661391,0.007875167,0.03450393,-0.026286641,0.007222735,-0.0323887,-0.0047813454,-0.03746727,-0.0150080975,-0.02526669,0.007370271,0.01940854,-0.089668766,-0.008454122,-0.00036880508,0.0796199,-2.2368113e-33,0.08607902,-0.11221777,-0.026494903,-0.1005846,-0.017974587,0.1024086,0.008139788,0.01011684,0.026054934,0.045075707,0.104389966,-0.0050598816,0.051143646,-0.025027102,0.016171077,0.030737968,-0.012841801,0.066738136,-0.057185862,-0.059198976,0.043753084,0.038002577,0.041338526,0.029296491,0.07383557,0.010058379,-0.01215486,0.008632979,0.018746184,0.12978786,-0.013335337,-0.05380496,-0.040383834,0.04119089,-0.058230285,0.06236952,-0.0776335,0.041845113,-0.044233706,-0.038815167,-0.009176537,0.029086519,-0.008315211,0.03299702,-0.00049562793,0.06235686,-0.052468795,0.004380309,0.047484443,-0.046784397,0.05567427,-0.0125905145,-0.100298434,-0.0675229,-0.10408994,0.054611042,0.06929839,-0.006827493,-0.007539715,0.06483416,-0.0071511604,-0.097388804,0.039001945,0.021880442,0.033310406,0.08942137,0.024240743,0.07697562,0.033683322,0.0018483278,0.036451243,0.0132957185,0.019223416,0.07513958,0.024685483,0.00089497986,-0.0098564485,-0.03622654,-0.03244,0.039659113,0.027203461,-0.03617772,-0.00012356922,0.00443786,-0.068495624,-0.1318067,0.01518128,0.04843748,-0.0014143278,0.017417746,-0.047187857,-0.008917946,-0.085380964,0.02817096,0.0670375,-3.936252e-08,0.03509873,-0.028780576,0.04176964,-0.051495977,0.07559184,0.041921567,-0.018876888,-0.054642744,0.008039904,-0.049754273,-0.0074180127,0.07750618,-0.022243595,0.04193749,0.019576082,-0.024048818,-0.03720044,0.02797303,9.937264e-05,0.05211919,0.027337315,-0.015240909,-0.08993022,0.02882027,-0.040986143,-0.08298465,-0.0053703776,0.047417063,0.028198168,-0.01747274,0.028406585,0.08872576,-0.0673273,0.013805716,-0.16327116,-0.018517626,0.0064867446,-0.010685597,-0.12913112,0.043434083,-0.05753762,-0.04245301,-0.09301662,0.0050891135,-0.009948985,0.018425595,-0.025915664,-0.030078966,0.022463577,-0.022377456,0.009213927,0.006910458,-0.0021508974,-0.022569025,-0.13206285,-0.011869243,-0.0041406434,-0.045717727,-0.013143563,-0.04962837,-0.012783634,-0.016665248,0.20246734,-0.013566103 +2.8.5.2,"The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. It catalyses two reactions in the pathway - early in the pathway it attaches a thiosulfate molecule to the sulfur atom of an L-cysteine of a SoxY protein; later it transfers a second thiosulfate molecule to a sulfane group that is already attached to the same cysteine residue.",384,1.0,-0.09613896,-0.022439294,-0.04766035,-0.005633971,0.030314643,0.02461367,-0.08596494,0.027637852,0.0024457006,-0.029947594,-0.013681948,0.023339737,-0.074588604,-0.008080857,-0.07475134,0.07072366,-0.10535593,0.07447793,-0.01687702,-0.04782762,0.06155294,0.060992505,-0.08510856,-0.009390943,0.031059247,0.11466722,0.020828472,0.00766037,-0.045689873,-0.035258546,-0.02320534,-0.037391573,0.008234746,-0.0050984886,-0.00013088358,0.07652527,-0.04110492,-0.046269577,0.054927833,-0.027059142,0.035164453,0.027515635,-0.05109183,0.005607729,-0.066813305,-0.040178105,0.010434017,0.0635027,0.009328292,-0.054869894,-0.048259456,-0.055619694,-0.0030582584,0.09749185,0.0042294427,0.04460666,-0.013396427,0.01359032,-0.04195994,-0.04136858,-0.010182473,0.033720914,-0.062403727,-0.00031447952,0.075989515,-0.08055059,-0.040803894,-0.016855195,-0.06695235,-0.036882088,-0.03901823,-0.012094103,-0.010122051,0.058721203,-0.0020809344,-0.004543264,-0.027368855,-0.052526977,0.094507925,-0.0009184156,0.054413535,0.0019436455,0.0008820549,0.096507035,0.03590441,-0.04733963,0.029486885,0.026429031,0.02729016,0.030628141,0.025433682,-0.029665582,-0.037722066,-0.05850483,-0.07196138,0.020283658,0.001803647,0.09140146,0.07409116,-0.015383179,0.021459531,0.039275207,0.01841677,-0.12356336,-0.0290035,0.031101538,0.001805916,0.08953234,0.0063895388,0.02050425,-0.0036613382,-0.00533493,0.030753428,-0.029886661,-0.033792485,0.09873903,0.02654081,-0.013967978,-0.052447572,-0.019925896,-0.0060650646,-0.007495731,-0.011604545,0.06502299,-0.01311153,0.006099939,-0.11911322,-8.708824e-34,0.062868156,0.035396352,-0.030128347,-0.096531935,-0.012701668,-0.06001735,-0.043003477,0.054579295,-0.05477378,0.047060832,-0.05071776,-0.018052936,-0.006303181,-0.01876067,-0.02384371,0.0256657,-0.06089022,0.0057528615,0.050267037,0.025525853,-0.0010318966,0.030885186,-0.068800166,0.029635195,-0.0012395845,0.061692473,-0.0070809,-0.034211524,-0.023132617,0.013874503,0.046276934,-0.042762253,-0.08155309,-0.041958213,0.058729533,-0.032105967,0.0099206045,0.0020206224,-0.038872983,0.0024269659,0.025185194,-0.0048038648,-0.023425609,-0.07498361,0.011570184,-0.09279161,-0.04889819,0.083914965,0.09507538,0.08006185,0.08456841,-0.115072764,0.116485104,-0.010511084,-0.0025342815,0.02561289,-0.0002703245,0.003615619,0.034274545,0.028839607,0.016067354,-0.020688007,-0.032860454,0.024393698,-0.015939508,0.029538885,-0.0013407719,-0.03982961,-0.012158251,0.082431264,-0.09977193,-0.06398112,0.037811395,0.019842675,-0.042085476,0.006621642,-0.006228502,0.020642504,0.045857232,0.013087436,-0.069417,-0.07896389,-0.05605548,0.0009021695,-0.06597196,-0.007406936,-0.009653284,-0.02549486,-0.085120484,0.025446173,0.01710447,-0.047622744,-0.0628614,0.05088444,0.03629538,-3.442251e-33,0.06216407,-0.08700251,0.032053594,-0.12461604,-0.049539912,0.048849598,0.01887403,-0.015944567,0.02762492,0.04052343,-0.05637318,-0.006134124,0.027578324,0.0026297402,0.023258967,-0.010220185,-0.004841458,0.055760883,-0.051610988,0.010272687,0.040037986,0.15626405,0.054566026,0.055418577,-0.0036409725,-0.031158678,0.0115179075,0.08102901,0.04109947,0.11815233,0.0138103,-0.022168225,0.018783726,-0.057278853,-0.06487719,0.11572549,-0.025220351,0.010172615,0.0576888,0.00985391,0.019263076,-0.023688572,0.017455988,0.14367959,0.004054895,0.049948312,-0.015047841,0.059292383,-0.012817298,-0.065040715,0.03514396,0.02532896,-0.002586316,0.062836744,-0.03291153,0.06402006,-0.056943726,-0.028318614,-0.020265764,-0.06583232,-0.096123256,-0.08655486,-0.05151148,-0.056926537,0.0011502481,-0.008278166,-0.049538136,-0.08968381,0.06320734,0.0016245404,0.0045796023,0.0371346,0.02320691,0.046010133,-0.0031427285,-0.03384431,-0.073502116,-0.03311008,-0.025833905,0.02292971,-0.055288885,0.06590292,-0.017822022,-0.09381332,0.0142835295,-0.047627583,-0.017323311,0.13711846,-0.008550504,0.0012160786,-0.008458798,0.06348893,-0.04438099,0.017235111,-0.0614642,-3.793194e-08,0.01110984,-0.052225314,0.06995835,0.00053656346,-0.012768042,0.07125043,0.06810465,0.10804144,0.020791462,0.00600213,0.022208305,0.14068615,-0.010592515,-0.0034831644,0.08588807,0.010157772,-0.06754225,0.0071207457,-0.053357705,-0.045936596,-0.006257372,-0.0472943,-0.030984117,0.07432759,0.0049987305,-0.03846161,0.038207598,-0.008907982,-0.08459548,0.022659587,0.082032904,0.08743123,-0.03694517,-0.03233561,-0.05915319,0.056384936,0.010823253,-0.034528177,0.0027508885,-0.05022757,-0.010062219,0.015306565,-0.16814506,0.033472076,-0.028760044,0.03716722,0.0062107877,0.05723659,-0.000961429,0.0065154843,0.005448003,-0.026103664,-0.059782125,-0.07078365,-0.059824035,0.0018920611,0.023343965,-0.040560715,0.03488719,-0.02400528,0.069258764,0.03479106,0.1718867,-0.059764333 +4.1.1.112,"Requires a divalent metal cation. The enzymes from the fish Gadus morhua (Atlantic cod) and the bacterium Micrococcus luteus prefer Mn2+, while those from the bacteria Pseudomonas putida and Pseudomonas aeruginosa prefer Mg2+. Unlike EC 7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)], there is no evidence of the enzyme's involvement in Na+ transport.",384,0.99999994,-0.03403731,-0.09085908,0.017827544,0.036173858,0.04076104,-0.0318376,0.01587435,0.02907692,-0.051017273,0.02744747,0.03363711,-0.089995675,-0.012588315,0.110489085,-0.029101124,-0.060603358,-0.02129474,0.010354244,0.0016183519,0.06885612,0.07766369,0.040938403,-0.07025271,-0.02486541,0.011931223,0.047012016,0.030994875,-0.05570422,0.004375221,-0.0332702,-0.11151486,-0.018838529,0.06214707,-0.06869014,0.031566642,0.014485958,-0.030339053,-0.0016324221,0.01248221,0.015947027,0.021518849,0.045815434,0.121298976,-0.02691718,-0.037629753,-0.11375785,0.06831945,-0.111369975,-0.0011627988,0.047084134,-0.038587157,-0.0356792,-0.024456464,0.06359576,0.028497392,0.043313075,-0.123836815,-0.058728278,-0.058742825,-0.038945824,-0.016938131,0.028060285,0.044350326,-0.02477166,0.047539636,-0.02285369,0.008047351,-0.005164759,-0.021480288,-0.024808777,0.020693937,-0.031810503,0.026412861,-0.0016706014,-0.016655702,0.035016134,0.07403505,-0.058711186,0.033173967,0.029871041,-0.027281787,-0.013722209,-0.013427671,-0.017146097,0.07923083,0.033100013,0.06474355,-0.0091018565,-0.06186816,0.029431093,0.09330561,0.013474991,0.0023924632,-0.038534254,-0.02045331,-0.023327813,-0.08626916,0.057473294,-0.0136722205,-0.017506838,0.05579843,0.056793638,-0.024450397,-0.06733172,0.011526945,-0.027664013,0.066144936,0.080095254,-0.0013236976,0.07502081,0.067791104,0.03316544,0.027052857,0.009534724,-0.03184199,0.07593017,-0.0066660093,-0.109551124,-0.0947992,-0.011883514,0.02083271,-0.04879179,0.04517432,0.01783303,-0.01991875,0.0077799866,-0.05475641,3.7362787e-33,-0.034485206,-0.07914341,-0.04494732,-0.01396134,0.029432097,-0.0103355795,-0.06477984,0.0076452494,0.03308733,-0.11448617,-0.10844169,0.05220277,0.02785997,0.067696325,-0.03754371,-0.0012419912,0.018425403,-0.08611147,0.10939016,0.012862886,0.09191964,0.013921999,0.03028414,0.0017141773,0.044984102,0.04151101,0.015235636,-0.08322489,0.02264906,0.02566463,0.05017163,-0.16400993,-0.06188047,0.075881705,0.09889001,0.03700024,-0.009025083,-0.009123136,-0.017171348,0.00033184362,-0.017519735,0.03236493,-0.07044813,0.08656486,0.04801886,-0.085277945,-0.008112695,0.106680036,0.0065912306,0.085480906,0.07711031,-0.07297974,0.005945751,-0.011073599,-0.0813712,0.03196602,-0.045435812,-0.011081335,0.02065015,0.03013346,-0.013462938,0.079898335,0.033582672,0.04014139,0.03962738,0.03967239,-0.07857426,-0.079635,0.022994978,0.029535769,-0.047722403,-0.05916045,0.0409221,0.06812788,-0.022342104,-0.034738008,-0.051047914,-0.03128149,0.042624615,-0.0115887495,-0.013062374,-0.009381668,0.01992289,0.020679856,-0.094646715,0.026772995,-0.008792121,0.013368031,0.07780162,0.05392029,0.08898709,-0.0070236726,-0.078749366,-0.012913543,0.009193415,-4.1732224e-33,0.07329575,-0.039115928,-0.0012256722,-0.036986586,-0.08940177,0.011394845,0.09242597,-0.016525242,0.11026994,-0.05953061,0.048261043,0.051467136,0.054590706,-0.025940405,0.06623125,-0.07760238,-0.0016733191,0.040261388,0.05854896,-0.086339645,-0.028234733,-0.008451424,-0.01722039,0.028271856,0.032574326,0.058374174,-0.056628782,0.046534225,-0.020937089,-0.033067245,-0.026004456,0.11180266,-0.01657894,-0.0697521,-0.1207593,0.054673154,0.005826093,0.043009043,-0.034607623,0.046466414,0.0115726665,0.018798713,0.014228524,0.100263044,-0.030694246,0.018538292,-0.027930096,-0.004198791,0.03630937,-0.06571972,0.063723095,0.0069019655,-0.031761058,-0.102654,0.10391433,0.03983647,-0.010048043,-0.022770032,-0.0016836764,-0.039359916,0.016833363,-0.043839898,0.024411697,-0.12635101,0.015757767,0.011180983,0.06727723,-0.00011929537,0.0027827518,-0.04314871,0.060583983,0.055505075,-0.005603785,-0.038972452,-0.053235058,-0.033088636,-0.038675096,-0.006047325,0.08692367,-0.06652409,0.051977776,0.052290842,0.029424002,-0.053479776,0.046158236,-0.006135248,0.015528974,0.054644328,-0.015814675,-0.011173643,-0.03838742,-0.091137506,-0.0631845,0.0010057989,-0.029850757,-4.3493102e-08,-0.0108762095,-0.02346825,-0.009161119,-0.02582689,-0.034882054,0.08470009,-0.021670105,-0.0012825632,0.08074012,-0.013754162,0.03683575,0.07163849,-0.038026225,0.013513045,0.03683644,0.052294828,-0.023213342,-0.0054927007,-0.07472633,-0.053479616,-0.09417377,0.005804313,-0.15193345,0.075345956,-0.0028959939,-0.0016226671,0.037598133,0.055169374,-0.013258862,-0.060270175,-0.026591823,0.0011392816,0.023467794,-0.023235498,-0.048671793,-0.027836416,0.020008441,0.009997245,-0.04526741,-0.033320416,-0.052203976,-0.0048576873,-0.015704747,-0.013834312,-0.047112573,-0.0077847303,-0.010007834,0.056981776,-0.017747696,-0.04625761,0.082190625,-0.07563175,-0.009173351,-0.008551605,-0.0575105,-0.0048601627,-0.013364529,-0.09165211,-0.06559302,0.025133543,-0.005035856,0.019980548,0.0896938,-0.0023018217 +4.1.99.24,"The enzymes from the bacteria Pseudomonas aeruginosa and Xenorhabdus nematophila are involved in the biosynthesis of paerucumarin and rhabduscin, respectively. According to the proposed mechanism, the enzyme forms an imine intermediate composed of linked L-tyrosine and D-ribulose 5-phosphate, followed by loss of the phosphate group and formation of a beta-keto imine and keto-enol tautomerization. This is followed by a C-C bond cleavage, the release of hydroxyacetone, and a retro aldol type reaction that releases formaldehyde and forms the final product [3]. cf. EC 4.1.99.25, L-tryptophan isonitrile synthase.",384,1.0,-0.09077561,-0.04974169,-0.044865005,-0.004790708,0.05030081,0.069345325,-0.08223361,0.034295674,0.073063925,0.020235084,0.034265973,-0.056288827,-0.0050425855,0.07351565,-0.08373145,0.0730458,-0.1033157,0.039973333,0.014353391,0.0005200076,0.032474615,0.11130209,-0.027845224,0.024205146,0.063799806,0.0141512845,0.061250176,-0.05693984,-0.060647715,-0.0116760945,-0.042768374,-0.11433369,0.010416177,-0.117522135,0.1010584,0.080563575,-0.020894773,-0.030314455,0.12379532,-0.04420611,0.001374563,-0.06791367,-0.05690202,-0.06212553,-0.049681116,0.016690124,0.0061742845,0.09113879,0.06425505,0.002662656,-0.0738511,-0.013160409,-0.01809674,-0.01110496,0.049641743,0.015244808,-0.02866253,-0.05336197,-0.027561568,0.047553457,0.0230183,-0.004053599,0.0038170568,-0.014713482,-0.025062162,-0.033442028,0.040196825,-0.018211741,0.072642565,-0.012614792,-0.0694924,-0.06249475,0.040645573,0.0002763129,0.0006501356,-0.00058062153,0.006399106,-0.017970653,-0.0005088686,-0.016318904,0.014392277,0.0011158779,0.03253326,0.07318346,0.026231572,-0.09957504,0.027275862,0.06578795,0.06174136,0.033004835,0.042461112,0.0016891701,-0.019739306,-0.08587276,0.008745789,0.0016389602,-0.043653682,0.05635934,0.012818784,-0.06980402,-0.004602811,-0.009212524,-0.017238714,-0.112074114,0.0094365785,-0.012599046,-0.011404517,0.09728361,0.048620906,-0.014241056,-0.056891255,-0.018954465,-0.023440905,-0.008267868,-0.03720544,0.09833517,0.010779134,-0.07471576,-0.10698815,-0.040742174,0.009182775,-0.05018373,0.043046884,0.122681506,-0.016918598,-0.029851995,-0.0979273,1.7756426e-33,0.061972894,0.09164133,-0.023905357,0.013618752,-0.0197408,-0.0040708273,-0.08607553,0.029574318,-0.013388259,-0.06292086,-0.030353067,-0.1248388,0.012184981,0.030143064,0.032899506,0.0022409724,-0.11311063,-0.0024166577,0.06796768,0.050265487,-0.015446824,0.04631653,-0.020451995,0.013967047,-0.0034284142,0.09766228,0.007943115,0.030960718,0.0019183514,-0.044813756,0.047879957,-0.046674397,-0.048783448,0.024687406,0.06823672,0.037511535,0.0038217427,0.0156166395,-0.014845808,0.081541754,0.028995637,0.056209363,-0.0337416,-0.050288,0.07396504,0.013031216,-0.05256377,0.08734932,0.030398488,0.049023386,0.07509745,-0.055400666,0.101347186,0.01773424,-0.032450374,-0.017944004,-0.038386926,0.001317043,0.024749465,-0.01510968,-0.010970333,0.004308303,0.036988374,0.023412628,-0.027592586,-0.0081919925,-0.019505097,-0.051009323,0.020679984,0.019700045,-0.05617851,0.0064148833,0.06677548,0.012462357,0.0073200217,-0.032083448,-0.107877985,0.019754292,0.005461982,0.026873393,0.08810267,0.020434672,0.006431395,-0.018993167,0.0013714889,-0.04451635,0.016969068,-0.016271172,0.018542504,0.030426681,0.036271896,-0.1339619,-0.05401498,0.09703035,-0.006717968,-2.351585e-33,0.12398606,-0.109270416,0.06976459,-0.059132744,-0.08921043,0.06677243,0.021096054,-0.0072723893,0.03635847,-0.024561407,0.07668257,0.019460443,0.04512188,0.015457832,-0.02912689,-0.06470975,0.082619995,0.051054746,-0.010860787,-0.053224828,0.024870688,-0.0026055556,0.0020149914,-0.012265607,0.0686317,0.08840414,-0.0025204925,0.057579644,0.032611787,0.054912835,-0.023674835,0.011299305,-0.04570113,-0.038666606,0.07307026,0.08103336,-0.09302108,0.03475507,0.037932225,-0.02129596,0.056579553,0.040317632,-0.01109713,0.027092587,-0.012956189,0.016174564,-0.022233043,-0.04329775,-0.05630423,-0.10453082,0.052448355,-0.0009666582,-0.024697505,0.006827745,-0.011386699,0.045997143,-0.019208465,0.04426024,0.034343477,-0.016680522,-0.09304816,-0.037942223,0.056491546,-0.077095345,-0.029527184,0.05587165,0.022537878,0.09249664,0.013649687,-0.011529676,0.048950955,-0.011087474,0.054950077,0.078772925,-0.033716306,-0.05027786,-0.025781566,-0.067048706,0.032005552,-0.016722865,0.0117230285,-0.030486818,-0.005641581,-0.033218484,-0.024349641,-0.0065140557,0.054403815,0.12563017,0.019795792,-0.021231472,0.064462,0.02857192,0.014899349,0.07586787,0.06728169,-4.9188323e-08,0.04058278,-0.07164747,0.032485113,-0.02927436,0.017596673,0.031917714,0.027522843,-0.053231157,0.017460471,-0.026151637,-0.01730476,0.05308714,-0.06264674,-0.012190281,-0.024824832,-0.032938015,-0.109611884,0.018538428,-0.018711638,-0.0032888884,-0.11562638,0.0049767,-0.13042969,-0.03840764,0.0076262867,-0.08070222,0.056036163,-0.033822685,0.032685988,-0.018436637,-0.03848993,0.029747678,-0.03984727,-0.033064637,-0.08233114,0.0027918261,-0.03782841,-0.0022088366,0.0033542486,-0.04772947,-0.008851091,-0.035760734,-0.05546068,0.012674134,0.037322275,0.010614942,-0.008609539,-0.025510097,-0.03777719,0.005319286,0.063816845,-0.0030548882,0.026768552,-0.10341138,-0.103905395,0.018615888,0.0063431645,-0.04055493,-0.026413344,-0.048550032,-0.02887424,-0.0030906466,0.1659652,0.032495614 +4.1.99.25,"The enzymes from cyanobacteria that belong to the Nostocales order participate in the biosynthesis of hapalindole-type alkaloids. According to the proposed mechanism, the enzyme forms an imine intermediate composed of linked L-tryptophan and D-ribulose 5-phosphate, followed by loss of the phosphate group and formation of a beta-keto imine and keto-enol tautomerization. This is followed by a C-C bond cleavage, the release of hydroxyacetone, and a retro aldol type reaction that releases formaldehyde and forms the final product [3]. cf. EC 4.1.99.24, L-tyrosine isonitrile synthase.",384,1.0,-0.064008124,0.00013168238,-0.041314717,0.013522562,-0.035634365,0.055387057,-0.06722867,0.004966193,0.045787983,0.06500877,-0.0076548588,-0.043210927,-0.04602896,-0.010553079,-0.06929212,0.10044913,-0.09918153,0.037995894,0.03364338,-0.017987678,0.05251736,0.08345935,-0.020577174,0.008580222,0.05528811,-0.018744657,-0.006314823,-0.021098917,-0.058493137,-0.044558793,-0.05655925,-0.07489132,0.04503416,-0.088927515,0.08288207,0.053644925,-0.07153675,-0.12613364,0.09180188,0.018684873,0.03401295,-0.04368959,-0.06103818,0.06907457,-0.09497248,-0.014025837,0.057869896,0.045501158,0.011306849,-0.035360888,-0.094009556,-0.04295309,-0.04240348,0.0125838695,-0.055218514,-0.00716857,-0.08098627,0.046568476,0.05919558,0.060144175,0.06862161,0.0611241,-0.02535611,-0.02597086,0.012419856,-0.07054167,0.0005532089,-0.04862564,0.0626668,-0.047607757,-0.039496902,-0.0996278,-0.047576,-0.004278484,-0.029549934,0.028413627,0.038369253,0.01377709,-0.04067241,-0.008836867,0.02869056,0.025304176,0.04505738,0.043474015,0.022042438,-0.046831504,-0.020614557,0.0715645,0.0064990604,0.032833856,0.10518195,3.574824e-05,0.0060068485,-0.05681086,0.047719285,0.014316998,0.041807447,0.10020327,0.028453806,-0.020549271,0.017793305,-0.010381941,-0.047920834,-0.042405035,0.03673924,0.022458745,-0.0034047721,-0.010859682,0.03492717,-0.026312765,-0.045566767,-0.014812479,-0.024785725,-0.0018994076,-0.005328925,0.084139004,0.03219249,-0.040619843,-0.010205417,-0.038625374,-0.032553174,-0.049147632,0.07923706,0.06473819,-0.01209082,0.073127195,-0.08270247,1.5453886e-33,0.116372935,0.06831556,0.033109702,-0.022291057,-0.0074808146,-0.06724954,-0.05546908,-0.0052300766,-0.029293418,-0.022493575,-0.12992205,-0.058241498,0.0125108855,-0.015858328,-0.014694243,0.023227153,-0.07881725,0.036592178,0.0720256,0.02409676,-0.058868643,0.027716193,-0.055943906,0.030025003,-0.064146444,0.074818134,0.00628626,-0.0067789815,0.011629061,-0.024821486,-0.025316617,-0.10278665,-0.028036585,-0.046853755,0.023339113,-0.057636604,0.009237167,0.018750472,-0.0012637532,0.025403056,-0.0029814795,0.070753984,-0.0006385786,-0.010251304,0.08969112,0.06679438,-0.066420645,0.06800069,0.07397648,0.004630981,0.02054132,-0.06941699,0.0741575,3.215723e-05,-0.041317105,0.032347105,-0.009556589,0.025705695,0.0658437,0.020678494,-0.015689133,0.0015364226,0.056726098,0.049620543,0.004308966,0.00072387565,-0.06275152,-0.058461983,0.013483492,0.041867536,-0.05321027,-0.041059382,0.07847279,0.0013858214,0.016765924,-0.0071770754,-0.0852718,-0.015441145,0.034385916,-0.010232409,0.09435998,-0.022341538,0.027798021,-0.022180239,0.07782629,-0.050069593,-0.041319497,-0.07133734,0.039098643,0.10801703,-0.06492805,-0.05730969,-0.07314746,0.046697684,-0.014080945,-2.036958e-33,0.14390723,-0.12623063,0.030847307,-0.074295975,-0.06432053,0.0638781,-0.06565618,-0.0024309389,0.031504944,0.06699545,0.11584692,-0.029588133,0.07254131,-0.012734218,-0.04552726,-0.12404742,0.022069333,0.08749618,-0.07067023,0.011849716,-0.030542577,-0.04083278,-0.014644062,-0.00110493,0.01674025,0.018825697,-0.025456369,0.06319448,0.024304632,0.062132217,0.009552637,0.012661558,-0.019383984,-0.04946515,0.03347456,0.0808538,-0.051292185,0.0049674273,0.039986596,0.023565328,0.0365615,-0.007898618,0.03619533,0.01235238,0.036268715,0.00497454,-0.031258643,-0.02595047,-0.088067494,-0.0738381,0.080812424,0.0090179825,-0.012135649,0.0009788027,-0.020445773,0.08162704,-0.006701601,0.03969204,0.015674789,0.0006592862,-0.0054628737,-0.058379725,0.06262493,-0.12044289,0.013196131,0.0654204,-0.013267857,0.122791626,0.04650373,-0.0073140734,0.04164879,-0.012658797,0.04934575,0.058788273,-0.0026100718,-0.030458143,-0.0050266883,-0.1187648,0.02482792,-0.03468631,-6.706031e-05,0.006020601,-0.00010528988,-0.05188009,-0.013517149,0.013161651,0.09764309,0.11784691,-0.0051219794,0.06914724,0.053851467,0.004078218,-0.05304234,0.12965629,0.02478112,-4.788814e-08,0.055178273,-0.030830499,0.035772003,0.03328582,-0.045615006,0.042523723,0.014321956,-0.014847344,0.018994315,-0.027328113,-0.0009997246,0.047066648,-0.0072048996,-0.0003127405,0.028893804,-0.024010174,-0.04242581,-0.016247569,-0.01893715,0.041737087,-0.05942264,0.01885213,-0.02515133,-0.018228889,0.017993627,-0.10224804,0.047655508,0.039129842,0.043131016,0.040692553,0.030610127,0.04376434,-0.026686756,0.017003061,-0.09743707,-0.012817261,-0.03550215,-0.045716014,-0.0024825404,-0.058629014,-0.0698143,-0.03274864,-0.089272395,0.030960819,-0.023893809,-0.0051463414,-0.012543511,0.05540819,-0.00806128,-0.0014137137,0.011304077,0.0065212836,-0.02964429,-0.07300799,-0.04127444,0.023181388,0.010716651,0.007098583,-0.03238663,-0.11608172,0.019244518,-0.047061022,0.16425134,0.007947799 +4.3.1.32,"The enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of factor 420 (coenzyme F420), a metabolite found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 2.5.1.147, 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to catalyse the condensation reaction.",384,1.0,-0.06312243,-0.040583774,-0.10266403,0.016495522,0.075160496,0.044076134,-0.06175649,0.11320218,-0.010590554,0.039653372,-0.014281297,-0.014573964,-0.09108886,0.0874641,-0.053179376,0.077051535,-0.06410863,0.010053774,-0.09087272,-0.053905975,0.058042794,0.020699264,-0.02986924,-0.00808776,0.027745318,-0.010921335,0.03986512,-0.002301933,-0.00083420455,-0.040964343,-0.009117888,0.0010773855,0.066152655,-0.044254653,0.015557398,0.070026755,-0.028920894,-0.08243394,0.04959556,0.0006252326,0.035570804,-0.012062511,0.014969007,0.008786272,0.0022419093,-0.0011397601,-0.0014920864,0.1139341,0.101657644,-0.007565945,-0.07304904,0.021219295,-0.044686336,0.030916633,0.036816858,-0.03138416,0.044618085,-0.07997949,-0.045343585,0.01866285,0.015891418,-0.0060230023,-0.021073876,-0.039528493,-0.026549887,0.04345278,0.05084798,-0.060124446,0.02930295,-0.013885092,-0.04920425,-0.031907074,0.0044299816,0.0509834,-0.04812103,-0.013986639,-0.017663375,-0.032285795,0.03908225,-0.017810643,0.10697736,0.0065620802,0.06558828,0.03029968,-0.012525165,-0.026566565,0.0002148559,-0.026805574,0.045917556,0.0208878,-0.009597853,0.01581711,-0.059340816,-0.06872864,-0.10062086,0.04138202,0.012450373,0.007133868,0.055133395,0.010529019,-0.030412396,0.032121055,-0.019033236,-0.086270824,-0.04944448,0.012690692,0.04126153,0.123198085,0.0032441872,0.035177182,0.0027021072,-0.019635076,0.044866882,0.014431788,-0.0019377029,0.031410743,0.01924057,-0.08809184,-0.056310248,0.0016144196,0.047220476,0.041602205,0.1024036,0.10064724,-0.08247866,0.03851247,-0.12886536,1.4620541e-33,0.09100842,0.073184066,-0.0069105453,0.021020569,0.008926659,-0.032273807,-0.086097084,0.06164375,0.011553374,0.009645368,-0.09622501,-0.06400087,0.040278837,-0.07154113,-0.0378239,-0.08002849,-0.0036832928,-0.011318902,0.02963162,0.04108038,0.019370412,0.07754968,-0.030373275,-0.014873941,0.028669957,0.10504643,-0.008038895,0.0141984075,0.07104416,0.000765457,-0.024465293,-0.08269869,-0.1390517,-0.01357148,0.06570295,-0.0339488,-0.075647205,-0.051073838,0.021588365,0.03634739,0.07110307,0.007812662,-0.022050373,-0.022989146,0.063351415,-0.042522255,-0.08153625,0.08007124,0.0891086,0.0790058,0.0358261,-0.017120874,0.06944759,-0.038004752,-0.025164958,-0.06471594,-0.04373511,0.0020907389,0.08499883,0.055551503,-0.021490864,0.034974102,-0.036019523,0.038190685,-0.038869284,-0.041151825,-0.02306327,-0.027589181,0.008964795,0.01958411,-0.002135184,0.005596137,0.07185271,0.03556975,0.05396468,-0.05546467,0.014300521,-0.052642334,0.036126558,-0.014764119,0.00016725763,0.018426064,-0.024056,0.0058485135,-0.044325512,0.017391644,-0.04706442,-0.013090331,-0.014018732,0.02818852,0.0032147642,-0.086659625,-0.002488646,0.0071291924,0.055183515,-2.2955134e-33,0.10604067,-0.120107144,0.02383252,-0.07050826,-0.024072543,0.062269557,0.017856985,-0.029719,0.027804926,0.034947425,0.11747158,-0.008881301,0.03869738,-0.057521172,0.0092479,0.0021162436,0.024726348,0.042080946,-0.054015018,-0.047953576,0.0127798505,0.061022736,0.045024335,0.025725678,0.06367406,0.03425797,0.020895878,0.015493641,0.02203534,0.14287505,-0.005691468,-0.020184584,-0.034213904,-0.028306976,-0.06688213,0.07180845,-0.0345658,-0.0014060064,-0.03815727,-0.048521973,-0.026030505,0.04737856,0.006613655,0.023162028,-0.009615071,0.07869803,-0.025836362,-0.045321077,0.049487803,-0.05647086,0.07853653,-0.03990917,-0.08441526,-0.037779745,-0.09299293,0.019778287,0.078125186,0.0019157175,-0.043754864,0.03202067,0.008968393,-0.108703606,0.05542929,-0.05390328,0.07713447,0.06532972,0.0064912923,0.07926066,0.056821145,-0.026747538,0.034983296,0.007238913,0.02666682,0.092816316,0.021469517,0.014006832,0.014060816,-0.033821452,-0.021103537,-0.013390484,0.0010866682,-0.036280833,-0.049037863,-0.022758387,-0.073072515,-0.13558604,0.020541172,0.086545154,-0.02571531,0.034442797,-0.057797115,0.01626378,-0.06497594,0.047777075,0.06577658,-4.4543306e-08,0.008363932,-0.02431027,0.020655163,-0.042566363,0.020594586,0.02436403,-0.038803715,-0.023240386,0.03838562,-0.052758902,-0.021136934,0.09730621,-0.030330665,0.031949367,0.03160847,-0.05101778,-0.0418785,0.026337417,-0.027933866,0.013428595,0.00075819786,0.006037586,-0.12462776,0.014600268,-0.030679058,-0.10641705,0.023096664,0.044451866,0.04827695,-0.030966002,0.015804255,0.06170793,-0.0628359,0.0012902042,-0.101248875,0.049725793,-0.0023473839,-0.019877091,-0.09437695,0.020932542,-0.0037446613,-0.022856088,-0.10197453,0.016276341,-0.0100180935,-0.0021547363,-0.0071639633,0.006528736,-0.0148672005,-0.0054358966,0.027052594,0.026132394,-0.002248409,-0.011005682,-0.11568875,0.0124918,0.0032366833,-0.078661814,-0.008223544,-0.050392825,0.049392525,-0.027407607,0.1975968,-0.028934836 +4.3.2.10,"The enzyme is involved in histidine biosynthesis, as well as purine nucleotide biosynthesis. The enzymes from archaea and bacteria are heterodimeric. A glutaminase component (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is transferred by a 25 A tunnel to a cyclase component, which adds it to the imidazole ring, leading to lysis of the molecule and cyclization of one of the products. The glutminase subunit is only active within the dimeric complex. In fungi and plants the two subunits are combined into a single polypeptide.",384,1.0,-0.0016923822,-0.05090418,-0.11836707,-0.08449472,0.04957365,0.021696486,-0.020090874,0.046789985,0.025466481,-0.0068963557,0.034246463,-0.06317063,-0.07834702,0.03636492,-0.08304319,-0.023892045,-0.107070714,0.0048233885,-0.0759939,-0.09422986,0.07526476,0.08249251,-0.08744347,-0.018537767,-0.02897446,0.01757596,0.0011775573,-0.06341569,-0.015829775,-0.03608324,-0.08463964,-0.105919465,0.12195062,-0.032822687,0.055025466,0.10408187,-0.05876669,-0.012638546,0.07812903,0.0050596828,0.038249508,0.020467754,0.0015220202,-0.0012244569,-0.06278845,0.07196286,0.032727838,0.0010253614,0.008461425,-0.021079568,0.0007751665,-0.032418344,-0.013146075,0.017643604,0.051095206,0.029124219,-0.054748625,-0.040191296,-0.041497264,-0.00070800574,0.03375417,-0.0153639885,-0.008417031,-0.06368013,0.038491208,-0.06422616,0.0670497,-0.076756805,-0.018172605,-0.06600134,-0.034835503,-0.047552522,-0.0382223,0.049912877,-0.006115636,0.029624654,-0.06979047,0.010436246,0.01737581,0.020562608,0.06406341,-0.006100035,0.044948984,0.027948689,0.01638781,-0.009682394,0.008424094,0.046055738,0.07732223,-0.013060088,0.029371733,-0.023291042,0.0038199518,-0.07220785,-0.053238127,0.018097032,0.050716087,0.015008259,0.019497558,-0.049013127,0.037589855,-0.007094529,-0.026557753,-0.06311032,-0.05570405,0.03595005,0.0033575953,0.10507746,0.016285595,0.057370856,-0.043247372,0.07971474,0.024076842,-0.007876025,-0.04186966,0.07193866,0.09150291,-0.03457018,-0.071424924,0.05035609,0.009497781,0.006772022,0.07734806,0.10541387,-0.056979723,0.019780787,-0.07254828,1.0937543e-33,0.033378255,0.044644736,-0.02305156,-0.006342856,0.00082447147,0.027479684,-0.08060498,-0.039160386,0.054790493,-0.027810479,-0.14014825,-0.032738816,0.023188137,0.0033333164,-0.038029872,0.05099802,-0.04295646,-0.013233351,0.057554804,0.0070621185,0.031334694,0.114437275,-0.052361395,0.0398139,0.042202458,-0.00619387,0.019253423,-0.029403588,0.03285023,-0.038716726,-0.028760593,-0.09210798,-0.09416128,0.015983485,0.092874676,0.0035518669,-0.041627593,-0.061395362,-0.001076391,0.018155392,-0.03156237,-0.0022966403,0.013350825,-0.05721815,0.049265366,-0.0018190615,-0.03511888,0.057412148,0.018225914,0.048727892,0.0074088634,-0.0035652965,0.09764044,-0.020889722,-0.047028206,0.03655758,0.020133507,-0.030622931,0.05305492,0.090930544,-0.0058475174,0.062808044,-0.033523113,0.00075647846,0.022660712,0.03775986,-0.11024736,-0.020730328,0.05967601,0.109405465,-0.026871243,-0.10303595,0.0003631992,0.06871771,-0.016840551,-0.056378838,-0.10973154,0.017240634,-0.03021922,0.043570075,0.0008166204,0.007101659,0.0011073278,-0.002006528,-0.08654034,-0.0013710214,0.006095171,-0.05335595,-0.023824105,0.01120437,0.026984371,-0.042939875,0.016782701,0.009551548,0.018512826,-3.4874074e-33,0.11669229,-0.099933,0.05625427,-0.050131965,-0.027198944,0.065866865,-0.04121137,-0.020041645,-0.012218761,0.001206116,0.008501618,0.045767862,-0.0053297486,0.009271023,-0.054365408,-0.020105252,0.041307528,0.11055221,-0.008987646,0.0040989947,-0.019663824,0.005837103,0.029783264,0.02885933,0.05414543,-0.027572686,0.014848501,0.060838252,0.0010557862,0.013304363,-0.034384057,-0.0006901287,-0.026963156,-0.07815485,-0.004963517,-0.008280615,-0.0181339,-0.038584802,0.011552339,-0.009015049,0.009901954,0.042280614,0.056295402,0.0687804,-0.0043402025,0.09406881,-0.09509418,0.053400066,-0.06088326,-0.06898393,0.010975988,0.01891604,-0.0038967386,-0.030479474,0.06969722,-0.0016941552,0.043262076,0.011456498,-0.010286603,0.023980107,-0.015397379,-0.099724926,-0.00011863508,-0.026572209,0.023583995,0.023701545,-0.04340662,0.04116957,0.013417583,0.06804995,0.024715632,-0.05127659,0.09842709,0.05791759,-0.03729682,-0.05901507,0.03644868,-0.051887505,0.06240142,-0.09690458,0.04099135,-0.041903183,0.04741546,-0.06913357,-0.028112868,-0.092376366,0.0869808,0.11484118,-0.0067116413,0.039090183,0.003035746,0.012096384,-0.009743943,0.0722512,0.07488437,-4.450673e-08,0.06721303,-0.025889236,0.0017919489,-0.090149425,-0.089081064,0.06277635,0.0042890846,0.021212025,0.07505277,-0.0062353173,-0.0001836738,0.041297957,-0.038779553,0.012152157,0.011224766,0.044932887,-0.087037355,0.027034791,-0.0030073184,0.020127853,-0.0900069,0.020832844,-0.16308324,0.0146191865,0.01598819,-0.06551043,0.049102228,0.082659096,-0.0031159357,0.0008615333,0.034357827,0.020234184,0.04584022,-0.061222557,-0.08850526,0.039348327,-0.038388647,-0.0131234,0.034613993,-0.0737417,0.008930631,0.03333316,-0.08803635,0.005264852,0.010182441,0.010428838,-0.012127763,0.06733143,-0.013829747,0.056391954,0.0505683,0.009029402,0.0815738,-0.059516143,-0.06522429,-0.06985897,-0.011633514,-0.08591152,-0.001583935,-0.026400978,0.013388649,-0.007668363,0.16402827,-0.01488477 +7.1.1.1,The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme.,384,1.0,-0.03999796,0.04479533,-0.05350734,0.016733317,0.0210528,0.043403678,-0.03533265,0.05857232,0.060526986,-0.015925338,0.014956125,0.061468966,-0.04647672,0.015327224,-0.053565346,0.018158063,-0.03572456,0.029576605,0.010672026,-0.07231071,0.054050844,0.0403875,-0.017968148,-0.061730854,0.05076532,0.01893771,0.04145406,-0.0105446745,-0.003995037,-0.022870973,-0.08308015,-0.051051017,-0.021597398,-0.045021906,0.037240203,0.10069377,-0.055154607,-0.0061633526,0.01441358,-0.009150162,-0.0004838659,0.042372826,-0.06858535,0.0069160527,-0.03952264,-0.01072888,0.019787688,0.055683922,0.0077516073,-0.0468134,-0.033725888,0.016077764,-0.036578193,0.03786449,0.017407514,-0.010778866,0.06251464,-0.08929506,-0.067799285,-0.03456977,0.0117299305,-0.0477994,-0.004869827,0.0071020327,0.050772864,-0.07777811,0.123330995,-0.028539162,-0.039161235,-0.10022917,-0.100292325,-0.0138487965,-0.017105581,-0.038808495,-0.026384858,0.008028682,-0.064743586,-0.06218756,0.06931962,0.045461144,0.08281149,-0.017989615,-0.046884764,0.07163718,0.06567811,-0.016283726,0.011751571,-0.01306468,0.00084506575,0.034515444,-0.045811012,-0.054897554,0.002744793,0.015986945,-0.17458144,-3.916974e-05,0.044014458,0.008141309,-0.009285792,-0.03157308,0.017018007,0.120019384,0.021650773,-0.047984764,-0.07417912,0.0050757336,-0.011542841,0.12165376,-0.020046191,0.00096867396,0.0036257254,0.0030597774,-0.0026527224,0.0012991511,-0.0023860468,0.09441646,0.08720123,0.017688222,-0.081843145,0.037948806,-0.027310861,0.009361295,-0.025224708,0.039789394,0.008699897,-1.8038298e-05,-0.096535906,7.612533e-33,0.08172606,0.035801783,-0.011806712,0.022476,0.033586126,0.02740229,-0.061495613,-0.012491344,-0.013200243,0.0017927937,-0.04142881,-0.061840244,0.025359323,-0.047241002,-0.00051029044,-0.006662562,-0.07163945,0.009735838,0.016685914,-0.017935872,0.032227967,0.031211263,0.007266223,-0.023694161,0.04189382,0.047962036,-0.087841034,0.06427595,0.0006761594,-0.0036271473,0.07033968,-0.067257516,-0.12096847,-0.032175325,0.1008234,-0.051876362,-0.05705469,-0.05093947,-3.525492e-05,0.055929862,-0.10494797,0.025418641,0.0029274335,-0.041144095,0.0857458,-0.11844353,-0.038417075,0.0721679,0.02428214,0.06683618,0.037658066,-0.045193624,0.11338791,-0.09581072,-0.025463797,-0.02846163,0.0062688123,-0.032105766,-0.015619503,0.10547152,0.07795684,0.045307834,-0.08656912,0.07335747,0.013954629,0.05077524,-0.051389724,-0.074593626,0.046708446,0.14291583,-0.06611132,0.041502185,0.027537838,0.055542257,-0.04313709,-0.0160445,-0.060247753,0.03310012,0.046035543,0.014658696,-0.02965078,-0.02067723,-0.024920033,-0.038141135,0.0016679704,0.014341579,0.01429223,-0.04510522,-0.010258585,0.0072574825,0.10407771,-0.026841557,-0.0142278,-0.05376489,0.025824979,-7.8121246e-33,0.085903704,-0.05997845,0.04629929,-0.13857676,-0.013023541,0.079305835,-0.0037236619,0.012458715,0.009602618,-0.047448803,-0.0305605,0.04767412,0.0642991,-0.0046783388,0.029593043,-0.042842325,0.002495021,0.039689504,-0.05482278,-0.0036276905,-0.004160065,0.09257904,0.06680232,-0.011003181,0.03310209,-0.060894396,-0.07281925,0.044914685,0.03258054,-0.0009977339,-0.022024855,-0.01119953,-0.05226838,-0.0488565,-0.014921631,0.05077307,-0.064433366,0.04103715,0.0651591,0.07111766,0.029390553,0.011087522,-0.052519247,0.014779435,0.010640709,0.061521426,-0.14622149,-0.027509922,0.03770423,-0.11442356,0.04575257,0.052467003,-0.010223952,-0.00065949425,0.07229494,0.014285741,-0.049199667,0.027727695,0.068939626,-0.00943215,-0.05247576,-0.07813627,0.023473775,0.028837897,0.02258811,0.0063677686,0.030574515,-0.0126766795,-0.00075421523,-0.005090498,0.034542844,0.04039716,-0.0045553427,0.032272074,-0.025205625,-0.04610572,-0.07167202,0.009224384,0.015428042,0.0047564013,0.039671175,-0.0053071375,-0.045337167,-0.066586874,0.0018604803,-0.073720396,0.016601088,0.050054602,0.017777368,0.0025775232,0.0020196768,0.037727594,-0.046156157,0.013150906,-0.019723143,-4.111651e-08,0.04875401,-0.022974113,0.054540418,-0.040487133,0.0045876447,0.06527602,0.069789104,-0.020531181,0.03930055,0.034097925,0.016020194,0.15171419,0.061317395,0.0023305924,0.027206343,0.040054116,-0.046173595,-0.0011394322,0.01599738,-0.052157547,-0.032514513,-0.026934648,-0.09448693,0.069850795,0.0730208,-0.03279245,0.003385507,-0.038819645,-0.007882467,-0.06719111,0.02839206,-0.025005449,0.08058949,-0.021344887,-0.08183184,0.0051624607,-0.013430699,0.014952024,-0.060525205,0.061967317,0.015585772,-0.025915757,-0.07445768,0.03020677,-0.02566282,0.079351194,0.035746615,-0.0106485095,-0.10463523,0.032433223,0.07548997,-0.052041836,0.02010805,-0.055200286,-0.13236855,0.01654174,0.019134833,-0.06327612,-0.06472029,-0.0364879,0.023604091,0.06610065,0.14021066,-0.008971016 +7.1.1.2,"The enzyme is a very large complex that participates in electron transfer chains of mitochondria and aerobic bacteria, transferring two electrons from NADH to a ubiquinone in the membrane's ubiquinone pool while pumping additional protons across the membrane, generating proton motive force. Different reports disagree whether the enzyme pumps 3 or 4 protons. Reversed electron transport through this enzyme can reduce NAD+ to NADH. ",384,1.0,-0.059337694,0.035325594,-0.08492871,0.019310843,0.0037452977,0.028385013,-0.035654992,-0.00804681,-0.01267148,-0.01323446,0.009695353,-0.024110869,-0.008211584,0.027212998,-0.048378058,0.013462568,-0.045801446,-0.006022809,-0.032128897,-0.02156517,0.051487308,-0.021884894,0.02594906,-0.078543566,0.024574207,0.025190866,-0.007915034,-0.025697168,-0.029045211,-0.08950243,-0.02292542,-0.031508718,-0.041928016,-0.051618755,-0.03312203,0.14178422,-0.068123065,-0.0066554113,0.018281106,0.057467707,0.056346845,-0.021989074,-0.011709068,0.024356974,-0.04719522,0.010551237,0.004652132,0.049514882,0.11073218,-0.0106778685,-0.041331302,-0.004178382,-0.003879957,0.037353158,0.02030543,0.048272174,0.042702634,0.019215377,-0.076085605,-0.0334412,0.06086649,-0.015967216,0.0036119297,0.036257032,0.061186995,-0.077190354,0.0022419712,-0.0016292435,-0.001030235,-0.08848242,-0.040179987,-0.04825318,-0.069612056,-0.024335088,0.0022264356,-0.035587188,-0.06574757,-0.019546581,0.06660531,0.0037063332,0.024559224,-0.047806785,-0.021157777,0.05853626,0.042342916,0.046803735,0.04475216,-0.053076643,0.0039026993,0.014586629,-0.009812275,-0.072252296,-0.03153103,0.03191013,-0.15677477,0.0087177185,0.04574503,0.057185624,-0.016739761,0.01527059,0.07940168,0.12289526,0.016982915,-0.100111485,-0.05874771,0.015748478,-0.009762736,0.11803452,-0.040073372,0.020577205,0.00071159616,-0.014725594,0.02854171,-0.026545351,0.00017697627,0.12412823,0.042343512,0.0021887117,-0.09480625,0.008178041,-0.023581067,0.018592332,0.008798592,0.018039696,0.018608168,-0.0076107644,-0.14936467,4.4730477e-33,0.048470657,-0.0022792453,-0.0038047582,-0.04904054,-0.008260735,-0.0037778195,-0.08417911,0.015246506,-0.04992195,-0.014837805,-0.026300319,-0.04915047,0.059249885,0.0119083095,-0.03640729,-0.03563261,-0.047909718,-0.04166876,0.050674647,0.028359227,0.043616682,0.025512703,-0.027774984,-0.057278242,0.04901192,0.01334384,-0.020358529,0.052692387,0.003149664,0.007953841,0.06298501,-0.08820329,-0.13045152,-0.01242114,0.018528834,0.014936424,-0.047055855,-0.05207213,0.032412782,-0.012304345,-0.08495073,0.033578545,-0.02489911,-0.04535837,0.05011853,-0.05662754,0.036651213,0.036342844,0.010394626,0.02580502,0.06974108,-0.07022607,0.119687945,-0.061742917,-0.04463014,0.035526756,0.028630579,0.038635228,-0.015092911,0.08256822,0.06506359,0.042098135,-0.10613503,0.11112532,0.009730603,0.04734745,-0.051625438,-0.047393013,0.03130041,0.109869294,-0.0983618,0.0013721591,0.019382637,0.0069305003,0.0265844,0.006954613,-0.07191993,-0.040918935,0.03195869,-0.010215382,-0.027513944,-0.08285619,0.006713084,-0.034025002,-0.02561387,0.0067771487,0.0067349607,-0.06269921,-0.02823017,-0.014273727,0.12509999,-0.017359221,0.008033604,-0.028109076,0.079934016,-6.368023e-33,0.0675069,-0.03593508,0.05548324,-0.10846096,0.011035712,0.10040167,0.03451819,-0.025679996,-0.029587572,-0.0013580486,0.021666607,0.022507625,0.019997587,-0.018894684,0.06128486,-0.029791994,-0.013981093,0.03562171,0.026313767,-0.0479399,0.013230455,0.14098357,0.054472744,-0.030857507,0.0005756519,-0.05411613,-0.04047389,0.014441609,0.10574804,0.015460829,-0.015094785,-0.06111505,-0.03643147,0.019909821,-0.02513491,0.055663906,-0.058910094,0.045648932,0.07795064,0.025521109,0.022554988,-0.039306812,-0.022776222,0.0021906286,0.020531882,0.10474932,-0.16509762,0.021329656,0.005764098,-0.079555616,0.029143872,0.037757434,-0.037396736,-0.013418182,0.05723999,0.060594175,0.026722535,-0.023634808,0.065224424,-0.039301056,-0.07667849,-0.05916187,0.00707327,-0.017579336,-0.041721296,0.012567107,-0.018883983,-0.027091539,0.021247925,-0.037912525,0.076573364,0.05538398,0.0036376351,0.044422776,-0.048994273,-0.049198654,-0.03757153,0.0026195054,-0.029084677,-0.019915028,0.024451295,0.025308516,0.0012534874,-0.05836768,0.04314701,-0.05191847,0.026781434,0.05666585,-0.020866968,0.032506175,0.0053259027,0.064407505,-0.0019528621,0.00868978,-0.0015868274,-3.8945544e-08,0.060396574,-0.041576207,0.07770993,-0.044966538,0.006795183,0.035903644,-0.0016237237,-0.00042119413,0.0334825,0.023677083,0.021573855,0.15566748,0.04411428,0.05401105,0.076850384,0.013401365,0.0028311445,-0.008197578,-0.017970664,-0.08779317,-0.042106926,-0.044071525,-0.14560024,0.08576471,0.042866625,-0.01355953,0.06277453,0.004691165,-0.035530113,-0.09761264,0.02209338,0.02215316,-0.018749883,-0.0065645683,-0.08737539,0.035538945,-0.039906263,-0.035803076,-0.0048145605,0.03013939,0.011671315,-0.050155517,-0.06254321,0.049363077,0.0020107268,0.04780201,0.042658243,-0.033459153,-0.06375739,0.003743739,0.041504577,-0.04496366,0.038406216,-0.078263275,-0.072775304,0.09303258,-0.09581698,-0.08193256,-0.013377122,-0.038985956,0.08717803,0.03771567,0.13484655,-0.04674015 +7.1.2.1,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane.",384,1.0,-0.058729872,0.0027698176,-0.017528174,-0.0127034765,-0.0024736812,0.024063392,0.0463653,0.03354494,0.07454741,0.019190254,0.036320772,0.0031295584,-0.06412488,0.105788454,-0.044481356,-0.076858565,-0.030772625,0.03509405,0.09513454,-0.060336426,0.075365186,0.0408432,0.018871166,0.0071911938,-0.053292472,0.0074028275,0.035331987,-0.023344152,-0.048393928,-0.035458956,-0.13870697,-0.0040671946,-0.0053080125,-0.0039385827,-0.004009119,0.16690958,-0.07825739,0.034039095,0.042553212,-0.018093364,0.16100344,-0.048266906,0.004297524,0.038939804,-0.058852475,-0.025752729,0.0369315,-0.0024026204,0.011714932,-0.06456134,-0.012173275,-0.04788231,-0.040130574,-0.022885747,-0.060479246,0.029474897,0.0009651918,0.0016206277,-0.027128208,-0.04446374,-0.02772675,0.009152055,0.028813321,0.052803177,0.07323885,-0.06725589,0.063327976,0.051592562,0.025732895,-0.054354247,-0.03821835,-0.011230047,-0.042657267,-0.028043278,-0.020164713,0.004681741,-0.036572922,0.030584987,-0.015926152,-0.03387768,0.065518774,0.0040827403,-0.05484819,-0.01921763,0.06457407,0.0045931586,0.0031788612,-0.012901896,0.02281056,-0.014701971,-0.018500386,-0.02444516,-0.018122785,0.02137769,-0.1350521,0.03721773,0.048472755,-0.005626788,0.06295866,0.0058700405,0.06442895,0.08115112,0.029751457,0.0054531908,-0.008775809,0.0048066163,-0.045900963,-0.017826935,0.025959037,0.07496819,-0.06530689,-0.006488079,0.03193031,-0.054150123,0.034376297,0.066922136,-0.030815644,0.019348929,0.011592294,0.038957715,-0.04443912,-0.08384065,-0.043200366,0.008063931,-0.01783693,0.073262684,-0.03440973,-6.459717e-34,0.011713009,-0.03023277,0.06746951,-0.007122286,-0.010483943,-0.007480905,-0.028542817,-0.061375584,-0.07307475,-0.1306453,-0.050211567,-0.02613934,0.03216518,0.0102556,-0.0017830521,-0.02637504,-0.07864296,0.03679959,0.13538186,-0.0051211976,0.011535803,0.016679486,-0.038722854,0.05143122,0.04478223,0.026993293,-0.00055575406,-0.018637534,0.038211722,-0.013293743,0.029967306,-0.040229212,-0.08785399,0.02078607,-0.018283917,-0.041576073,-0.08007793,-0.023800401,0.068383425,-0.06751562,-0.10827558,-0.064071424,-0.001247159,-0.029799813,0.029624943,-0.049627528,-0.052474502,0.077691674,-0.0073350775,0.061094906,0.028486673,-0.07940693,0.12569647,-9.097991e-05,-0.056429084,-0.0058787125,0.0037088885,-0.0060921432,-0.013751244,0.027060114,0.11841274,0.11408611,-0.042385407,-0.006668603,-0.018223274,0.040576756,-0.10630948,-0.083453484,0.060883813,0.10960623,-0.06463499,-0.004504341,-0.012617762,0.014298612,0.03498435,0.035463274,-0.032437455,-0.01653654,-0.045857,0.06305608,-0.022977207,-0.060738567,0.050929397,0.030117374,-0.04052082,-0.04353373,-0.0044351546,-0.0287671,-0.0024835938,-0.028765604,0.07998698,0.017927798,-0.0021103742,0.0789504,0.03255623,-9.831133e-34,0.112373866,-0.022496229,0.06287552,-0.06687915,-0.037839636,0.0020637682,-0.0145783555,-0.00714166,-0.03234179,-0.002730806,-0.05511177,-0.0035566853,0.0015190745,-0.046813503,-0.0014415584,-0.062442355,-0.031262316,0.084477566,0.06292905,0.043701258,0.0153987855,0.09113694,0.02197402,0.05314777,0.025584606,-0.03826901,0.014097572,0.05488237,-0.03706777,0.018373538,-0.027147045,0.024697635,-0.029986363,0.021291977,-0.06660395,-0.002216975,0.016543435,-0.008802322,0.02764764,0.0744656,0.047792714,0.062492475,0.09326109,0.031108584,0.032072563,0.061528273,-0.03747166,0.032008905,-0.02738783,-0.037689578,-0.0044632056,0.101959884,-0.07111505,0.006979741,0.04377929,0.036441658,0.015999448,0.03043829,-0.009705056,-0.057442892,-0.06882507,-0.1158472,0.012329642,0.023949377,-0.020902572,-0.015393891,0.0009585495,-0.029870993,-0.001212636,0.051863335,0.072449125,0.120722,-0.029238954,0.0149217965,0.0064467266,0.009211221,-0.00020118635,-0.021778421,-0.022816906,-0.023445493,-0.017424865,0.03739142,-0.0073382645,-0.0719348,-0.012964081,-0.09542085,-0.0025106526,0.013007574,-0.010924503,0.018972937,0.02111768,-0.049050573,-0.022069907,0.021062119,0.007445254,-2.8263907e-08,0.035152256,0.011842049,0.07857355,-0.06032556,0.038537893,-0.0022037707,0.04382889,-0.021710245,0.10117041,0.0020896625,-0.020464044,0.0226792,0.07727969,-0.0019480481,0.11589842,0.094456695,-0.029915482,0.07393818,-0.051987275,-0.04380249,0.008286749,-0.031814106,-0.17895028,0.11159364,0.07516895,-0.021206792,0.049348533,0.027266935,-0.05292487,-0.080677114,0.009775065,0.013954977,0.0366644,-0.016638903,-0.027709542,0.062043637,-0.047834784,-0.012351325,-0.07211748,0.01501725,-0.056992695,-0.07152054,-0.037442196,-0.014627778,0.01679449,0.047907934,0.01781511,0.02098195,-0.019230504,0.01117561,0.057889573,0.016559353,-0.022419795,-0.1392527,-0.09825036,0.0031995145,0.00516793,-0.06513174,-0.03217773,-0.05578918,0.08189952,0.0010305903,0.15110134,-0.045482278 +7.1.2.2,"A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. Within this complex, the gamma- and epsilon-subunits, as well as the 9--12 c subunits rotate by consecutive 120_degree_ angles and perform parts of ATP synthesis. This movement is driven by the H+ electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H+ rather than synthesize ATP.",384,1.0,-0.054206133,-0.039191883,-0.061123185,-0.06865402,0.02127505,-0.0042615947,-0.039910726,0.006219932,0.09885063,-0.046676178,0.07303459,-0.029022437,0.009387649,0.0596548,0.002168443,-0.11230847,-0.08166465,0.09683917,-0.023636965,-0.03451405,0.049359404,-0.021321397,0.023941876,-0.02377029,-0.029893283,0.023888847,0.027750103,-0.010363423,-0.055910874,-0.06208723,-0.16048634,-0.04335338,-0.024622215,0.010073817,0.0112270815,0.10958147,-0.10533069,-0.02281974,0.008060124,-0.03831037,0.069546536,0.026307482,0.036881935,0.053516597,-0.08164064,-0.018224966,0.07746628,-0.038278963,0.014285339,-0.027331065,0.0069387667,-0.02741727,-0.038419746,0.05788095,-0.030379092,0.081218936,-0.059733048,0.019920247,-0.012623927,-0.0064175637,0.0084839,0.028743617,0.044700652,-0.012099193,-0.0017083179,-0.06354191,0.016286789,-0.0119686,-0.011135416,-0.06565362,-0.013523252,-0.010824253,-0.07531149,0.014084024,0.017367043,-0.014212383,-0.022709588,0.036647934,0.035440274,-0.018646324,0.046428364,-0.003962504,-0.0025693371,0.07162751,0.05749972,-0.038813923,0.019201338,-0.0005871281,0.015566141,0.034564745,0.0391184,0.02185058,-0.056431863,-0.04120056,-0.06264347,0.007905402,0.028464984,0.06449936,0.0043428014,-0.027535578,0.09474881,0.058056317,0.056112234,-0.022892328,0.049011696,0.014369752,0.0029836681,0.08432652,-0.028865306,0.041193563,0.007846908,0.011785195,0.056759365,-0.055931073,0.0377621,0.07492915,-0.008497454,-0.018739512,-0.027771475,0.059801545,-0.04412621,-0.063235216,0.011397615,0.04359659,0.0023856573,0.03505888,-0.1605933,6.5001127e-34,-0.005660143,0.0036418254,0.041072357,0.029076304,-0.031096023,-0.021065012,-0.052616864,-0.048349597,-0.04703549,-0.027302029,-0.067333564,-0.009220093,0.01966147,-0.018723685,0.0051040384,-0.067278355,-0.041092537,0.039249558,0.0411932,-0.04786195,0.04040474,0.04835449,0.039421998,-0.07768185,0.06588745,-0.009106744,-0.024877504,0.011160594,0.038256124,0.02488209,0.016023919,-0.11900291,-0.116505735,-0.0059275534,0.04300211,0.010452078,-0.08052291,-0.0020263244,0.027316619,-0.03479311,-0.086828075,0.017424177,-0.029556641,-0.05521341,0.07182491,-0.007502017,0.005994062,0.08552732,-0.020929271,0.057728726,0.004436184,-0.067596704,0.12420089,-0.06307454,-0.012518324,0.02404369,0.022955824,0.05095022,-0.032361627,0.060437605,0.10059223,0.08785029,-0.0418681,0.014080034,0.04188967,0.062797464,-0.11592267,-0.1116095,0.067192376,0.053689376,-0.038224086,-0.0060118875,0.03284853,-0.013224521,0.02576715,0.022435337,-0.048781697,0.00909843,-0.021712994,0.009186284,0.03700923,-0.02645931,0.07982241,0.005534699,-0.03256117,-0.03772351,-0.0155744,-0.020495277,-0.009170069,0.037047364,0.11197453,-0.018328981,-0.024943933,0.026394533,-0.024226088,-1.5262e-33,0.050558057,-0.08329678,0.02760088,-0.15656136,-0.06937014,0.08923686,-0.02652235,-0.05089676,-0.036748093,-0.06424545,-0.0017655807,0.010180105,-0.092575945,-0.040788554,-0.037162524,-0.055403795,-0.031360116,0.06936623,0.05711012,0.024858752,-0.01049741,0.08543391,0.04995728,0.1394832,-0.027620256,-0.023646548,0.0025888144,0.06984003,0.015821146,0.037785925,-0.03761965,-0.00035242797,-0.005627432,0.04838273,-0.075915225,-0.063700765,0.015473147,0.033760276,0.056136068,0.07211187,0.052384045,0.020297835,0.040162776,-0.079991736,-0.01388079,0.07075952,-0.011199906,0.016009929,-0.072583385,-0.070469625,-0.04102335,-0.036162376,-0.04132887,0.055645734,0.042261586,0.031395234,-0.005124473,0.053867154,0.090847015,-0.045412496,-0.0680206,-0.07117092,0.033443023,-0.07361851,-0.00072521286,0.01857915,-0.016228413,-0.043686483,-0.01929197,0.034316823,0.008185535,0.023069002,-0.002032489,-0.02124699,0.040054474,-0.013903219,0.078804314,-0.05432792,-0.003259469,-0.072717875,-0.03983605,0.042235296,-0.07334029,-0.06259737,0.01861372,-0.028314684,0.037392702,0.07428894,0.04051343,0.03454209,0.07420899,-0.014776636,-0.027015692,0.036412597,0.07605326,-4.420912e-08,0.04478987,0.04926746,0.04771803,-0.010430083,-0.00062052405,0.06774471,0.05925625,0.014812852,0.08026396,0.031302873,0.0087321615,0.0645568,0.043417584,-0.04316437,0.04319727,0.07899125,-0.070627704,0.07311393,-0.008376298,-0.02013452,0.014565725,0.007295455,-0.109453805,0.08039059,0.10584449,-0.06528206,-0.043413103,-0.03578516,-0.022040326,-0.05265368,0.02664794,0.028581716,0.018189989,-0.039743233,-0.08845391,0.021552248,-0.031986475,0.010586509,-0.08898488,-0.00465969,-0.010799179,-0.08098776,-0.042922605,-0.011024467,0.0460472,0.06762118,0.030104702,0.04485416,-0.0037136385,0.030031087,-0.0025989697,-0.003520908,0.03302209,-0.08110303,-0.10662931,-0.013330016,0.016643664,-0.08578302,-0.029255431,-0.0023613668,0.109116144,-0.0056655062,0.107454814,-0.016832598 +7.1.3.1,"This enzyme, found in plants and fungi, couples the energy from diphosphate hydrolysis to active proton translocation across the tonoplast into the vacuole. The enzyme acts cooperatively with cytosolic soluble diphosphatases to regulate the cytosolic diphosphate level.",384,1.0,-0.054701407,0.01380512,-0.041830007,-0.02175017,0.020274997,0.014232655,-0.008864064,0.052049104,0.021557875,0.02847579,0.03627857,-0.018648077,-0.044727378,-0.025195751,-0.067975976,0.024422748,0.009338484,0.024048029,-0.0129909655,-0.10027413,0.11857601,0.014647502,0.029315947,-0.05198018,0.049358185,0.010544148,-0.025607549,0.041580595,-0.0032608386,-0.1047629,-0.07875515,0.009934289,-0.046496797,-0.030125948,0.038267694,0.15113148,-0.060828704,-0.012111974,0.024329454,0.032282583,0.06690556,-0.06916397,-0.0076695816,-0.051692147,-0.079818025,0.009344074,0.0028078223,0.014155302,0.058815308,-0.007876347,-0.017495587,-0.06266847,0.0455219,0.016567381,-0.04114916,0.06038978,0.011642185,0.025028335,-0.02130149,-0.028097663,-0.0014486269,0.01510908,-0.033182558,-0.02560291,0.07225761,-0.1177614,0.054171324,-0.023191977,0.020818748,-0.061774347,-0.06870755,-0.04735184,-0.04785446,0.0121946065,-0.0514369,0.010089543,-0.019390078,-0.06558738,0.0901196,-0.05693966,0.060881685,0.022008615,-0.0560023,0.0072264927,-0.0051504495,0.003205727,0.0016563024,0.022789322,0.052771665,0.0024276313,-0.01039217,-0.011698919,-0.016052555,-0.026823435,-0.08074617,0.06918133,0.038403515,-0.035088908,0.025115287,-0.0030429119,0.051462587,0.074744076,0.007915633,-0.09882335,-0.040024973,0.023872305,-0.06373071,0.07213461,0.034097925,0.017752701,0.0104061,0.031935927,0.041952375,0.00030742987,-0.046409488,0.07629014,0.02064768,-0.043510698,-0.08565895,-0.036208905,0.019097563,-0.0384004,-0.056108978,0.07925338,0.0006319112,0.035177484,-0.09038553,3.6547592e-33,0.036890138,-0.014864751,0.027186716,-0.014057483,-0.01808706,0.00044802838,-0.054700904,0.013083921,-0.10126879,0.013868142,-0.085078485,-0.08410505,0.08123154,0.022769708,-0.058744144,-0.051466145,-0.013602308,0.020947175,0.05362853,0.009239012,0.029344894,0.044042237,-0.055670664,-0.011221843,-0.010662592,0.043530207,-0.05795586,-0.0030999717,0.05405231,-0.016772736,0.05574313,-0.019620666,-0.07383787,0.0004148868,0.09632737,-0.06699832,0.015386062,-0.06954606,-0.017365245,0.0072208494,0.0009439202,0.010246445,0.04170823,-0.07348476,0.017408498,-0.06049697,-0.023765163,0.049218383,0.06330422,0.032652464,0.08546312,-0.06609669,0.13796772,0.020972185,0.012235993,0.043335065,-0.03353092,-0.022571368,0.03852377,0.031751975,0.00090055226,0.037746914,-0.07327863,0.030483799,0.03690305,0.007840211,-0.076698564,-0.06174846,0.033299774,0.14372824,-0.061558075,0.027622268,-0.049834345,0.029576972,-0.019817231,-0.016298963,-0.06624002,0.01371373,-0.02144964,0.022935512,0.034885265,-0.08383902,0.06548705,-0.026678603,-0.06311664,-0.015762176,0.022881687,-0.0616913,-0.03148107,0.026198054,0.046442714,-0.033991694,-0.030579558,0.0019729203,0.039620616,-4.3564515e-33,0.103310436,-0.035160717,-0.008301411,-0.07942625,-0.036345605,0.077070855,-0.008629402,-0.07812546,-0.04927109,0.002449978,0.0069086356,-0.0014354888,0.03946434,-0.05914793,0.027820444,0.027778609,-0.017217053,0.057348102,-0.0106189065,0.024922313,-0.09488993,0.12506512,0.035302147,0.051999096,0.053327873,-0.056036066,-0.015581599,0.04074012,-0.03152135,0.04727863,-0.038631573,-0.0018203919,-0.054154847,-0.043777056,0.009301331,0.034632884,-0.03786796,0.006892914,0.09378498,0.05582285,-0.028686374,0.037281986,0.049417395,0.03616364,0.029578242,0.060023967,-0.0921569,0.031953067,-0.08169942,-0.033287752,0.03781106,0.032563735,0.013887529,0.047454838,0.05973282,0.03144719,-0.024606412,0.03429754,0.006148434,-0.08459774,-0.035106264,-0.10414848,0.0062577203,-0.0013694117,0.035962272,0.14327346,0.01856332,0.010800992,0.016038021,0.0080601955,0.032617364,0.008700945,0.04497234,0.010087937,-0.034939926,-0.0018470099,-0.00935836,0.012566961,0.00092495536,-0.05140508,0.022200696,0.022815187,-0.011019961,-0.19674133,-0.008489507,-0.061153136,-0.041327685,0.11793565,0.01717291,0.02688998,-0.060852833,-0.042061675,-0.031740915,-0.001271905,0.10998859,-3.5578008e-08,0.03729624,-0.023186944,0.04098796,-0.05210071,-0.020736262,0.0420163,0.07836853,-0.0014580365,0.06723401,0.032918073,0.002340111,0.051123865,0.07205791,0.009750455,0.10555484,0.034515142,0.0115551,0.119615056,-0.057441156,-0.018259438,-0.027414422,-0.019441787,-0.13758664,0.08360622,0.034596507,0.0019317992,0.0602835,0.0040927967,0.024456928,-0.039021187,0.012989356,0.054552864,0.014716862,-0.074804485,-0.073844254,0.10497731,-0.051887397,0.0055841766,-0.028778195,0.032729,0.008870149,-0.024336351,-0.096842885,-0.02237436,-0.08488896,0.046748042,0.02123384,0.055076003,0.020729642,0.0649204,0.023972118,0.027787011,0.016784225,-0.0816866,-0.11308864,-0.028621513,0.011322701,-0.047228225,-0.020341316,-0.054942247,0.03250825,0.032066397,0.13160785,-0.04019366 +7.2.1.1,"An iron-sulfur flavoprotein, containing two covalently bound molecules of FMN, one noncovalently bound FAD, one riboflavin, and one [2Fe-2S] cluster.",384,1.0,-0.03176028,-0.061815143,-0.14066793,0.111762516,0.07521011,0.03372819,0.009866394,0.06536478,0.024572685,-0.113237396,-0.004414715,0.020042194,-0.08014244,0.010003927,-0.09372741,0.0031193923,-0.033034403,-0.008293188,-0.039319165,0.032185897,-0.05567468,-0.0043880413,0.05776936,-0.047469035,-0.07309507,0.03366343,0.026411586,-0.016894013,-0.0038979908,-0.021469098,0.05763633,0.047944557,0.040799182,0.0315018,-0.04636379,0.04641818,0.07091367,-0.049381558,-0.035918184,-0.039755937,0.023750558,-0.011413228,0.012031225,-0.027336847,0.074013226,-0.024807354,-0.040922552,0.08693084,-0.019238314,0.06255046,-0.052140366,-0.036206722,-0.09059608,0.08858173,0.06247657,0.033599213,-0.020639189,-0.08754607,-0.031336434,0.054612983,0.023167474,-0.031018099,0.025772348,-0.021115033,0.060978916,-0.015054605,0.012365244,-0.034913093,0.046532366,0.0096184295,0.017042734,0.056253735,-0.11714727,0.026727812,0.015760459,0.10673589,-0.016278718,-0.008472286,0.09411168,-0.0575627,0.0038633132,-0.022747083,0.08042532,0.10545004,0.023470946,-0.057634756,-0.042834807,-0.006457145,-0.011188127,0.073231235,-0.034958746,0.058993567,0.06382199,-0.0061414447,-0.06224162,0.040639527,0.041538853,0.051512245,-0.07984328,0.06578048,-0.048563853,0.0038504219,0.000296038,-0.038481865,-0.05284591,-0.059362646,-0.029965684,0.041111857,0.014049257,-0.014647399,0.0245968,-0.034658466,0.013098223,-0.11466247,0.017066753,0.021820774,0.014768021,0.009140671,0.027240708,0.029033959,-0.010115579,0.11849736,-0.0060060886,0.07624068,0.03486097,-0.05040864,-0.14399219,1.9032497e-33,0.06935518,0.032507975,0.053780645,0.03169151,-0.033199612,-0.035699908,-0.07869493,-0.012697408,-0.0017895494,0.041711982,-0.110744946,0.01994612,0.054945573,-0.08815957,0.054046735,-0.07534357,-0.016554844,-0.052549582,0.104867324,-0.075767614,0.029585054,0.09382798,0.031723134,0.00568678,0.014911242,-0.011239872,-0.04014862,-0.016436106,-0.0034838305,0.019909654,-0.0021397222,-0.050485387,-0.049076024,0.005996855,0.022717316,-0.03919088,-0.065872476,-0.08833924,-0.10265835,0.032262444,0.02371885,-0.025354758,-0.023253022,-0.022748621,0.0463699,-0.05791373,-0.07490986,0.054389752,-0.022700034,0.048454523,0.00068849995,-0.021196801,0.049332976,0.08837629,-0.08575753,-0.006246864,0.008393223,0.033107743,0.052442323,0.025342718,-0.010528012,0.0051301084,0.025961632,0.026465254,-0.039651718,0.014816506,-0.035523783,-0.019767398,0.04318362,0.047956273,0.070495784,0.020258445,0.096384384,-0.008432964,0.011857156,-0.018798009,-0.027621083,-0.0565974,-0.007754677,0.054702815,-0.05307206,-0.06615845,-0.03649037,-0.013273895,-0.09385139,0.021406524,-0.020923393,-0.055871803,-0.021100163,-0.06577262,-0.03339054,0.0084483875,0.0014454387,-0.06476021,0.02623675,-2.4608827e-33,-0.019963967,-0.103591666,-0.03998452,0.023227513,-0.015907561,0.009184667,-0.017441215,-0.057425674,-0.035380255,0.030938111,0.09170183,-0.08658911,0.016077219,-0.06321641,0.020961376,0.07737045,-0.008789445,0.047240335,0.10939745,0.040643588,-0.079956196,-0.016673377,0.041797128,0.1284304,0.01848468,0.020657968,0.07747584,-0.06148048,0.009875554,0.111734085,-0.03400049,0.0018863906,-0.040804207,-0.0747951,-0.009708699,-0.011839929,0.03749269,-0.029830331,0.007874009,-0.011233536,-0.02368926,0.017746994,0.033270754,0.11170428,0.0682247,0.07164014,-0.002055321,0.048447154,0.04264048,-0.016874785,0.01499127,-0.012155832,-0.034546994,0.089871526,0.0039276495,0.029142069,0.037395343,0.07280636,0.021926498,0.06471055,-0.0063511045,-0.1059836,0.019808877,-0.025339117,0.07426553,0.035067666,0.023712635,0.070192724,-0.008340235,-0.03163161,0.06539681,-0.018070817,0.06570774,0.020190723,0.030762978,0.001779349,0.057622455,0.08225559,-0.05280388,0.033886224,0.032186102,-0.029093368,-0.006563812,0.0006761831,0.014066657,-0.13778104,0.0349344,0.08083258,-0.027033981,0.028980957,-0.014235064,0.07650991,-0.024657132,-0.06778629,-0.015445295,-2.995172e-08,0.010745352,-0.061591413,-0.009747081,-0.018373275,0.085493855,0.0021982046,-0.025067609,-0.04579764,-0.08794209,0.03645855,-0.0054739285,0.10410902,-0.062938705,-0.030606631,0.036075164,-0.026622236,-0.03730283,0.04447974,-0.03626045,-0.0170541,-0.014497228,0.038085766,-0.042955037,-0.06723034,-0.058381293,-0.060318746,-0.037121214,-0.10479589,0.08029084,-0.04122297,0.02236781,0.07990853,0.010567261,-0.054408554,-0.13675854,-0.0005717636,0.018756233,-0.022272239,-0.06610877,0.049761944,-0.09629823,0.016347956,-0.021742469,-0.008143787,-0.00863121,-0.033163432,0.037370663,0.040470984,-0.041243937,-0.004472403,0.0156076,0.04799016,0.013441601,-0.006197677,-0.03935988,0.0138493525,0.016311333,-0.041968487,0.034022465,-0.03834114,-0.031957455,-0.04834223,0.04763986,0.014490113 +7.2.1.2,"This iron-sulfur and flavin-containing electron transport complex, isolated from the bacterium Acetobacterium woodii, couples the energy from reduction of NAD+ by ferredoxin to pumping sodium ions out of the cell, generating a gradient across the cytoplasmic membrane. ",384,0.99999994,-0.11189398,0.01178913,-0.14136665,0.08377347,0.037912454,0.034872256,0.045356188,-0.0038421648,0.041458797,-0.03768832,-0.017713984,-0.051607415,-0.022151208,0.0021362377,-0.054591957,-0.060252957,-0.031156367,0.046126477,-0.02702123,0.054265346,0.01908793,0.03734318,-0.003085484,-0.06603617,0.023560887,0.060207542,0.009258392,0.0014855312,-0.020473914,-0.10003446,0.04179461,-0.015791966,-0.005574324,-0.025632197,0.015932085,0.10498774,-0.030099617,-0.04078684,0.062134992,-0.009196095,0.017265419,0.043481655,0.07822087,-0.027914291,-0.027115632,-0.05521853,0.029041808,-0.004662553,0.06382883,-0.031477895,-0.03429742,-0.019407729,-0.03881557,0.07415338,0.034086306,0.01509604,0.0126493955,-0.100055836,0.019609295,-0.029981734,0.048305064,-0.008996968,0.017543646,0.024724986,-0.034728114,-0.062161453,0.040048666,-0.022042472,0.009045535,-0.059546143,-0.06626431,0.013486821,-0.05432038,-0.013144374,0.0025461903,-0.0045349007,0.01125627,-0.017874172,0.08523888,0.026673673,0.00041774946,-0.016414043,-0.05997288,0.12499582,-0.012418684,0.00029617923,0.0033491072,0.03359764,-0.04605025,0.0354287,-0.017114446,0.011052463,0.007789925,-0.026867157,-0.10901511,0.0053148484,0.06976275,0.034764096,0.035982184,0.033728786,0.016474953,0.10729272,0.0633696,-0.10960604,-0.02502738,-0.049711727,0.01742726,0.17389928,-0.0033725507,0.01355399,-0.002319825,-0.04778966,-0.023972735,-0.06567599,-0.029148165,0.105779886,0.041590963,-0.042967822,-0.051933542,0.05132644,0.011229296,-0.0011167058,0.02487029,0.027338622,0.010783791,-0.013166841,-0.13400124,2.0523206e-33,0.04877644,0.0062489966,0.017097237,-0.012903835,0.031803463,-0.040985215,-0.09405365,-0.05574968,0.023370432,-0.022593936,-0.14564267,-0.034415618,0.04373903,-0.040559135,-0.04976217,0.0007570783,-0.11014339,-0.10480652,0.103760734,-0.00017669583,0.085233025,0.04215149,0.02405668,-0.0037407386,0.06562915,0.024157614,-0.03295555,0.015572361,0.011968739,0.0065803993,0.11492172,-0.051326446,-0.13409841,-0.018720457,0.11102981,0.02762459,-0.043352243,-0.0504124,0.0074428604,0.04606739,-0.022237474,0.021323739,0.0021763665,0.0014199383,0.07587693,-0.039361253,-0.043957178,0.05212655,0.041606117,0.052904535,0.0057262215,-0.084936075,0.080420725,-0.034465846,-0.07781259,0.015274862,0.020003842,0.06273504,0.00978095,0.07103535,0.07240742,0.06587533,-0.009756393,0.053626403,0.017543286,0.06488568,-0.02784208,-0.012916977,0.017024927,-0.033039834,-0.029982666,-0.013070486,0.08819703,-0.044807944,0.091432214,0.051943645,-0.079033345,-0.064168856,0.031120418,-0.021846918,-0.02567192,-0.061755635,0.04001465,-0.034355965,-0.04766127,-0.022040015,-0.033329718,0.022133417,-0.013723234,0.003138609,0.079537496,-0.024911553,-0.06440278,-0.07202878,-0.03296414,-3.7034354e-33,0.0312405,-0.023603085,0.04839668,-0.0993412,-0.055222444,0.09196292,-0.021073705,-0.025260027,-0.007545231,0.076864816,0.081465155,0.023848783,0.035077307,-0.06292012,0.066203766,-0.003336047,0.01690982,0.015146458,0.029741604,0.008485845,-0.009779705,0.022855908,0.0026937013,-0.025219038,0.034655184,-0.018917166,-0.024931684,-0.028575944,0.060240697,0.05932258,-0.036748298,-0.02560162,-0.059371278,-0.11576835,-0.078356095,0.017240906,-0.028795213,-0.0064095985,0.004700067,-0.00045847092,0.0028891796,-0.04996531,0.014473605,0.084636025,0.06258977,0.050291225,-0.08500857,-0.032055378,-0.015681637,0.03409575,0.039610464,-0.008307548,-0.04127458,-0.04705305,0.02465028,0.056990705,0.053739335,0.06822689,0.038232233,-0.06181636,-0.038118944,-0.085667506,0.0013507054,-0.035379738,0.053245284,0.08024373,0.0130471485,0.006209955,-0.007923312,-0.078600116,0.043394614,0.0017872051,0.01893605,0.0076948903,0.02988773,-0.016559517,0.018783508,-0.0064078844,-0.040317476,0.01651445,0.044185158,0.030749109,-0.02748344,-0.098209806,0.09896533,-0.036402073,-0.016431961,0.030240392,-0.030877046,-0.017886465,-0.015557235,0.03284898,-0.025120718,-0.03979603,-0.058595672,-3.074949e-08,-0.024418963,-0.018018879,0.0004240724,-0.07897364,0.04966468,0.036105555,0.010538213,-0.009055039,0.010336027,0.017090693,0.024666017,0.16850892,0.04180921,0.0031331659,0.058493953,0.066588715,-0.040763456,-0.009686527,-0.013432368,-0.059994865,-0.0021162962,-0.027145186,-0.095453516,0.10375383,0.07743676,-0.062452983,0.02864328,-0.08849566,0.025371905,-0.08098592,-0.023189602,0.0687521,-0.007917135,-0.021158522,-0.1357883,0.010705328,-0.035949096,-0.034248736,-0.026365839,0.04502343,-0.01472573,-0.017110473,-0.07189527,0.011031904,0.007602704,0.07936307,-0.029784897,0.063398026,-0.06865441,-0.0035157439,0.029958649,-0.013538848,0.013081235,-0.051833272,-0.10001694,0.056843027,0.001981669,-0.067816,0.0522978,0.020976502,0.034841206,-0.029834924,0.06813045,0.021912642 +7.2.2.1,"A multisubunit ATPase transporter found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis. The enzyme is similar to EC 7.1.2.2 (H+-transporting two-sector ATPase) but pumps Na+ rather than H+. By analogy to EC 7.1.2.2, it is likely that the enzyme pumps 4 sodium ions for every ATP molecule that is hydrolysed. cf. EC 7.2.2.3, P-type Na+ transporter and EC 7.2.2.4, ABC-type Na+ transporter.",384,1.0,-0.05253916,-0.05885951,0.024840748,-0.01342193,0.035232957,0.05873249,-0.0053797406,0.006432413,0.0031737299,-0.021451134,0.025685621,-0.09891707,0.02148583,0.102427624,-0.048380785,-0.07061071,-0.062734105,0.05225613,-0.0057424083,-0.09175128,0.04550127,0.056347556,0.00082884316,0.03602071,-0.009301125,0.03444689,-0.0049066376,-0.091034055,-0.011479369,-0.08925587,-0.09825753,-0.06467129,-0.029031625,-0.0180589,-0.0145792365,0.090372555,-0.120032586,0.01407583,0.02339247,0.05049002,0.12617786,-0.008168129,0.076968074,0.01851463,-0.067329064,-0.05057794,-0.0032777023,-0.052397985,0.06078387,-0.024377631,-0.032719187,-0.045928523,-0.0017227372,0.035270866,0.045967333,0.050864812,-0.118431136,-0.0284272,-0.004768975,0.0119973,0.08469282,0.07948479,0.08650133,0.005971432,0.055948492,-0.044628337,0.0040561873,0.021108132,-0.0018809112,-0.06262225,-0.04707189,-0.06720294,0.016156226,0.08743654,0.048728112,-0.03768967,-0.009146759,-0.03094226,-0.03965088,-0.012883804,0.05088609,-0.011540822,-0.035224732,0.007073835,0.04535154,-0.03344004,0.02812799,-0.039863043,0.0059954594,0.0021630041,0.022501934,-0.021994907,0.02947204,-0.073188365,-0.059829324,-0.025328957,-0.073694475,0.10566706,-0.01922309,-0.02603843,0.06986669,0.09260096,0.039981645,-0.013420442,0.02104463,-0.03502783,0.0315128,0.047610726,-0.0060073305,0.07188661,-0.0011706087,0.011609432,0.017692888,-0.044536933,-0.010994807,0.104492314,-0.03276162,-0.018367875,-0.04387477,0.048096143,0.00020848186,-0.11898762,0.06518492,-0.028869664,0.04691041,0.042453714,-0.09747547,2.3236695e-33,-0.023402367,-0.041720264,0.0014342071,0.007848962,-0.01782128,-0.021898052,-0.10469911,0.01149173,-0.004255608,-0.13158222,-0.045114465,0.06565737,0.010069321,0.066366196,-0.043250315,-0.06461965,-0.0710418,-0.018190505,0.11755823,-0.07893848,0.030394014,0.06038486,-0.025949288,0.033712484,0.0278756,-0.019843668,0.012010581,-0.026525693,0.047268312,0.0045849895,0.027093455,-0.059362102,-0.088054396,0.040012825,-0.018779583,-0.04179114,-0.050864674,-0.03412304,0.05515107,-0.020074347,-0.1329941,0.02926457,0.00090226077,0.020330714,0.032065593,-0.07650268,-0.09453471,0.0498195,0.014333046,0.029542666,0.03607466,-0.10337124,0.0433756,-0.07920286,-0.024965372,0.057910085,-0.021239506,0.010099435,-0.014192656,0.04200194,0.03260502,0.09878885,-0.03725851,-0.030100502,0.053061746,0.0372349,-0.06078661,-0.14152727,0.05117701,0.04478711,-0.069659054,-0.00095106754,0.0441058,0.06967374,0.03247491,-0.032534063,-0.06789883,0.009459928,-0.020562025,-0.02884591,-0.022835009,-0.092993386,0.091153964,0.09791017,0.017232792,-0.016878573,-0.017394153,-0.013393036,0.04772183,0.021502323,0.09528919,0.034651797,-0.07782544,0.031636897,-0.0010465634,-2.3193e-33,0.07594402,-0.03298974,-0.018848732,-0.016276358,-0.05973703,0.022783445,0.042731747,-0.0031136784,0.00069855957,-0.03682334,0.040452197,0.05088743,0.09496542,-0.041430783,0.028646147,-0.03541525,-0.00046832248,0.019048324,-0.018670224,-0.002379666,0.024928885,0.070912965,-0.010533131,0.0004585415,0.0043055373,0.014782417,-0.06174012,0.065351546,0.014022886,0.016432242,0.0035601987,0.0052985875,-0.024559377,-0.058265865,-0.13894016,-0.00050758617,-0.0063949334,0.038427092,-0.06554407,0.018754818,0.027985701,0.008626826,0.07364466,0.014018689,0.055812422,0.09773154,0.047332287,0.0003506736,0.02013498,-0.047743827,0.005936734,-0.019156847,-0.0401949,-0.0003700613,0.03580177,0.03974062,-0.00023481254,-0.0067148576,0.016589515,-0.06989396,-0.015327679,-0.039856996,0.08789777,-0.09327856,-0.03402851,-0.024760075,-0.011330932,-0.008967592,-0.03990051,-0.0059234514,0.06947379,-0.017963825,0.034471765,-0.047328204,-0.011728939,0.0054491647,-0.046057615,0.03118309,0.021190308,-0.039075658,-0.03686677,0.083099306,-0.042130664,-0.056068473,0.07478843,-0.011815751,0.020419883,0.08211301,0.05927935,0.018453883,0.0037842027,-0.005150404,-0.06230824,0.00359782,-0.023898207,-4.2708503e-08,0.04450156,-0.043424144,0.015591811,-0.0662013,0.02573114,0.055280987,0.01869283,0.037133686,0.11083657,0.025121033,0.0056106523,0.065573744,0.018721992,0.0023361945,0.08713142,0.063348815,0.007899,0.111921884,-0.039862927,-0.03585972,-0.032012556,-0.0041704383,-0.088364296,0.08730331,0.05301696,0.006618733,0.06480561,0.022193149,-0.05190165,-0.097634174,0.011048152,0.050957683,0.07529426,-0.030702919,-0.014721776,0.08384443,-0.008226025,0.05474269,-0.060809635,0.00865928,-0.06059565,-0.06815746,-0.09107894,0.0297459,0.06454031,0.045529358,0.014751676,0.0484947,-0.017404998,-0.03095609,0.02038559,-0.07405436,0.017237773,-0.041255098,-0.03926703,-0.029503057,-0.05137689,-0.10983249,0.006288706,0.011166681,0.042992003,0.009852343,0.09289194,0.044335887 +7.2.2.2,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports some heavy metals, especially Cd2+, from the cytosol into the vacuole.",384,0.99999994,-0.057245385,-0.044062875,-0.014987778,-0.028031128,-0.074019045,0.005997061,0.08114514,0.045802206,0.03513421,-0.046252083,0.023587553,-0.054544706,-0.05193974,0.05668434,-0.0378695,-0.07993744,-0.021261876,0.03733998,0.031366047,-0.0010108505,0.03101491,0.091338046,0.01108625,0.02688933,-0.066948615,0.0021940693,-0.034861527,-0.068458155,-0.02473937,-0.039351255,-0.10689513,0.004555591,-0.023856187,0.04265436,0.008584988,0.11643198,0.0011619914,0.02183309,0.0348297,0.026751408,0.09897263,-0.0026757407,0.055892333,0.0825445,-0.1339574,-0.0031379997,0.06162284,-0.008909393,-0.013051333,0.013390334,-0.035076942,-0.01263527,-0.02721954,0.024793155,-0.025572706,0.0431751,-0.0049658744,0.002121209,-0.0039396146,-0.042169075,-0.031944845,0.0032876781,0.061087046,0.09286448,0.06721454,-0.04339785,-0.035546143,0.049942408,-0.0034150083,-0.01263592,-0.07181553,-0.061472215,-0.10579156,0.05206219,0.058173303,-0.0014312374,0.018865917,-0.020502405,-0.0062618465,-0.04098899,0.011972422,0.001330148,0.0031231227,-0.028663184,0.039720133,0.016971802,0.0015074246,0.020603355,0.012816351,0.013462972,-0.021046866,-0.02038421,0.04600888,0.00076996157,-0.109446,0.03294556,0.03218125,0.040241983,0.019935142,0.0045776274,0.07860319,0.079473995,0.07762766,-0.0030544284,0.029361771,0.018557785,-0.008272789,-0.0005415935,-0.020223022,0.03655263,-0.013191433,0.0244105,0.007095907,-0.087013945,-0.0050399406,0.035236493,-0.041398842,0.016778318,-0.020788308,-0.020255795,-0.057232648,-0.08901273,-0.025349015,-0.046337564,-0.03237765,0.011304248,-0.040750932,-8.247651e-34,-0.11306726,-0.071049064,0.026274262,-0.0030117203,-0.01035593,-0.03719576,-0.008243338,-0.047473066,-0.031865936,-0.06636038,-0.010492873,0.017792443,-0.03566054,0.15105364,-0.012291148,-0.037672866,-0.05138402,0.066517025,0.1413022,-0.041739672,0.033230368,0.04720701,-0.015090263,-0.03388093,0.08179769,0.014669184,-0.044054404,-0.012515257,0.045481753,-0.016383445,0.01058873,-0.04133026,-0.054318577,-0.023473663,0.005025652,-0.06490462,-0.039496165,0.004147741,0.039541718,-0.07519832,-0.10638497,-0.0431533,-0.08266953,0.09076779,0.047549542,-0.050689727,-0.03635465,0.027935615,-0.018677818,0.025333121,0.032345377,-0.11641835,0.08594882,-0.036884923,-0.00019386447,-0.0071612266,-0.012794205,0.06028194,-0.045419853,0.076544136,0.037420888,0.17746703,-0.042217545,0.045731638,0.030514702,-0.007505587,-0.10119086,-0.12572595,0.04638448,0.10163734,-0.018883565,0.05874013,0.041601285,0.02146979,0.07627195,-0.0013644064,-0.069900736,-0.08427973,-0.044675693,0.060060054,-0.04760483,-0.09074608,0.03355673,0.01008891,-0.07751755,-0.037234172,-0.004650645,-0.023328878,0.009806892,-0.05134509,0.11798141,0.047588166,-0.037757773,0.09791568,0.037713017,-8.027859e-34,0.11433311,0.0040975795,0.12421736,-0.036632463,-0.051581163,-0.004669952,0.026351482,-0.031177744,-0.020761123,-0.03088922,-0.015961098,0.029803574,-0.0022208653,-0.039575197,0.04052655,-0.06904322,-0.03221481,0.04433994,-0.027261337,-0.0011871137,-0.00049086526,0.04887802,-0.015941095,0.07743334,-0.039783645,-0.043181937,-0.031201044,0.08125792,-0.0077539706,0.016434738,-0.020560833,0.053407792,0.040395267,-0.04760799,-0.05618824,0.0041315025,0.0066142706,0.0573177,-0.028743058,0.03346767,0.039311506,0.04135734,-0.012765858,0.019913845,-0.004294479,0.08882375,-0.030958518,0.049515404,0.025576647,-0.012386698,0.03251738,0.02869101,-0.03905304,0.011689708,0.11360254,0.10529705,-0.030704554,-0.028851317,0.06797914,-0.06806623,-0.059430417,-0.06385678,0.07555905,-0.03468491,0.017354775,-0.0251907,0.00796444,-0.066876866,-0.059594084,0.089881055,0.12156466,0.06438692,-0.01057218,0.0076051606,0.042648353,0.007203934,-0.014189061,-0.05070983,-0.083834015,0.0050951857,-0.016372113,0.050741438,0.03428618,0.0020561605,0.09217377,-0.0052047973,-0.014331561,-0.024815485,-0.01807842,0.041398596,0.028621087,-0.056554947,-0.009023108,0.06615726,-0.06687096,-3.454833e-08,0.006826885,-0.00374487,0.01242091,-0.11821107,-0.015100805,0.039386045,0.01634185,0.006709012,0.07621392,0.07523637,-0.01589494,0.0742714,0.014803584,0.05566071,0.10231005,0.05830271,-0.023888001,0.018530665,-0.021061767,-0.06732189,-0.010850344,-0.028082589,-0.035446785,0.09875799,0.042015273,-0.031116296,0.018714447,0.05047136,-0.013210825,-0.07057895,0.03426868,0.0219095,-0.010959602,0.015812157,-0.030642256,0.043628797,-0.061682034,-0.035195936,-0.07899185,0.075715065,-0.01787612,-0.06637879,-0.043121297,0.014216974,0.030521901,0.0038465373,-0.035225105,0.057129093,-0.020473132,-0.026396688,0.043514945,0.014317586,-0.0424102,-0.047981825,-0.07221555,-0.015590519,-0.07383771,-0.017029159,-0.031819496,-0.012939081,0.058343936,0.0056519806,0.12406957,-0.046139855 +7.2.2.3,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed. Some forms can also export Li+ ions. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.4, ABC-type Na+ transporter.",384,0.99999994,-0.037738062,-0.04671027,0.03766153,-0.005435313,0.043581024,0.0433179,0.062820494,-0.009831174,0.018990086,0.003788699,0.028458659,-0.010131264,-0.057110693,0.08182423,-0.057890307,-0.11960591,-0.068984345,0.038641352,0.04016575,-0.02997626,0.10451282,0.028040892,0.025658457,0.028269622,-0.023990683,0.002187356,0.03545246,-0.077883534,0.017015932,-0.07435966,-0.12654692,-0.0016638588,-0.027985306,-0.022795964,-0.0052196663,0.10811192,-0.075737216,0.056549724,0.014159409,-0.035752997,0.15153988,-0.041371487,0.06118054,0.05370456,-0.066714466,-0.021800406,0.034067124,-0.055264104,0.0027838845,-0.0140672745,-0.004461091,-0.03066999,-0.08235175,0.009029149,-0.022223484,0.036161248,-0.06646383,-0.003196598,-0.0016744412,0.008928164,-0.0055954764,0.04136165,0.006826528,0.048291862,0.059649054,-0.04451885,0.055718694,0.06468628,-0.00643859,-0.07288067,-0.03530893,-0.032116722,-0.055769484,-0.028561974,0.024702063,-0.026030445,-0.0021772021,-0.011209126,-0.03178054,-0.018855013,0.03947263,0.013873412,-0.025788175,-0.011803829,0.0771008,-0.026984653,-0.010279702,-0.033020053,0.028832491,-0.008461309,-0.027891207,-0.0035233153,0.03382713,0.03446185,-0.0737155,0.031687513,-0.004723316,0.08168942,0.017061193,0.018941374,0.084325425,0.13915202,0.052437525,0.0018221018,-0.011121993,-0.0127942525,-0.014282799,-0.027612047,-0.0019387694,0.10218707,-0.005618694,0.020935724,0.047916237,-0.07805081,0.028851721,0.08259671,-0.040062204,-0.017184112,0.01794751,-0.014441435,-0.0076399217,-0.08634838,0.024461813,0.0102028465,-0.006661973,0.036877923,-0.039713904,-4.2812115e-34,-0.06402344,-0.02875287,0.012941593,0.011399049,-0.039800942,0.029455813,-0.07581469,-0.045551866,-0.0616626,-0.12643062,-0.04682522,0.031174755,-0.019579714,0.081984535,-0.032492414,-0.060500354,-0.013079708,0.038858995,0.13875146,-0.011640868,0.020603184,0.047385782,-0.040329874,0.064872384,0.07191209,0.03619628,0.017668117,-0.02090072,0.009149053,-0.006788886,0.053635657,-0.07653502,-0.09323105,0.030377734,-0.051648844,-0.01956971,-0.066587225,-0.007587355,0.057329934,-0.05009853,-0.120317936,-0.011370624,-0.032100447,0.006136886,-0.007025654,-0.05564492,-0.055114795,0.026709616,0.009944619,0.042867,0.016663939,-0.08057398,0.0679482,-0.017852273,-0.06645807,0.025088537,-0.014607917,-0.0026228204,-0.023662563,0.03494009,0.09562138,0.13721392,-0.00089463225,0.02074578,-0.003228419,0.022839246,-0.09773159,-0.12726538,0.06945992,0.02518197,-0.094480716,0.010002903,0.04468408,0.027325818,0.08162249,-0.002034706,-0.07261427,-0.0071686134,-0.022450786,0.04488952,-0.059193302,-0.10058861,0.04963772,0.055407297,-0.03985184,-0.047742113,-0.026508207,-0.02559788,0.04817684,-0.041800994,0.049129486,-0.0013883191,-0.009084199,0.08213514,0.03171838,-8.741643e-34,0.10738485,-0.025772976,0.060666334,-0.09583045,-0.068382785,0.015812194,0.07401593,-0.034726605,-0.030917069,-0.0009150482,-0.0007980523,0.00012856271,0.033276513,-0.055631775,0.01237362,-0.06654232,0.010327248,0.08052119,0.030592717,0.018509544,0.030000445,0.08091287,0.0036218264,0.04540534,0.019460369,0.009354661,0.021030487,0.088091396,0.0012397486,0.0035256476,-0.020957625,0.03422124,-0.01186269,-0.005981315,-0.14173022,-0.012337858,-0.02069723,0.040231235,-0.037575662,0.04758757,0.08274866,0.042025283,0.06330493,0.002315017,0.031745754,0.04738976,0.0044039404,0.02497676,0.036965173,-0.057072215,0.047182497,0.09255291,-0.0910382,-0.0022748527,0.06672811,0.065000616,0.014004543,0.012990981,-0.026836425,-0.075984344,-0.06752045,-0.06267309,0.05863297,-0.096341655,-0.013187314,-0.053131014,0.00043693604,-0.031310692,-0.03777345,0.053475723,0.06680597,0.104663946,0.0036174038,-0.005629989,0.019515548,-0.008174582,-0.005041401,-0.03507581,0.02038058,-0.071380444,-0.030892292,0.02241142,0.026076332,-0.02746145,0.030318812,-0.071352564,0.0056194924,0.004709233,0.042759437,0.0059458013,0.011559283,-0.049118,-0.07025884,0.03485082,-0.034317058,-3.5085005e-08,0.014439938,-0.039055694,0.010212902,-0.070342876,0.01488704,0.014482163,0.025569923,-0.014822652,0.07161164,0.017190423,-0.021091195,0.043436833,0.04727981,0.023484802,0.08513964,0.09427176,-0.006665497,0.10005708,-0.048490144,-0.06887381,-0.017932285,-0.023567384,-0.1303666,0.107208185,0.011193266,-0.02325327,0.053224854,0.009082214,-0.0136523545,-0.11493573,-0.022923348,0.051846303,0.036182597,-0.006050043,-0.024680799,0.04476718,0.0028106833,0.0016682948,-0.054699805,0.049975406,-0.07115355,-0.055993326,-0.023092933,0.006507322,0.030196706,0.02922352,0.0009974363,0.0065414836,-0.011115825,0.038684912,0.07316159,0.006839069,-0.017019672,-0.09513781,-0.08062617,0.008702019,-0.06002713,-0.082139656,-0.011877056,-0.019981757,0.070354715,-0.040673748,0.1345233,-0.039830387 +7.2.2.4,"ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This bacterial enzyme, characterized from Bacillus subtilis, exports Na+ ions out of the cell. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.3, P-type Na+ transporter.",384,1.0,-0.08431607,-0.07140928,0.017436452,-0.017198745,-0.05471146,0.0050287847,0.057138123,0.07355087,0.037908435,-0.061513167,0.02004627,-0.09759442,0.028203355,0.1257581,-0.036226936,-0.06566444,-0.06342749,-0.00058591133,0.034333393,-0.008645759,0.04933998,0.11446036,-0.043679275,0.04474536,-0.061606564,0.0039867763,0.033112448,-0.058905628,-0.032327536,-0.043467436,-0.10551937,-0.007232039,0.0061500682,-0.001245033,0.0022360394,0.0497563,-0.06042271,0.03662348,0.10029234,0.019583346,0.104104176,0.023101741,0.13551818,0.04301086,-0.10290495,-0.02803609,0.044641156,-0.023771798,0.025030026,-0.018338874,-0.016621513,0.0050626453,-0.07631336,0.05765894,0.0083786035,0.009050972,-0.0536496,-0.017736912,0.003765581,0.00019415075,0.037743893,0.035687212,0.11397888,0.030195046,0.025412655,-0.031609725,-0.04793528,0.012252024,-0.020123245,-0.06257229,-0.10202464,-0.05084077,-0.026506823,0.057548147,0.056038287,-0.03286528,-0.00901655,0.00036621996,-0.05108091,-0.029124612,0.0076777614,-0.019144025,-0.05698628,0.042194884,0.0324234,-0.028731445,0.042616088,-0.007540152,0.011511805,0.030059857,-0.021724196,-0.011132526,0.08280903,-0.051040195,-0.094022036,-0.04623676,-0.050987024,0.068084076,0.028772032,-0.00977745,0.050082855,0.064634435,0.06961736,0.0066682138,0.0043668263,-0.065489,0.036391333,0.03674235,0.0063125165,0.033603806,0.010871112,0.04660346,-0.0077915103,-0.107522614,-0.021947077,0.06397644,-0.041524988,0.015197182,-0.024181271,0.0005120688,-0.007243154,-0.11961588,0.020111423,-0.06534375,0.028872738,0.020575691,-0.06521643,-1.4257242e-33,-0.10279467,-0.055595744,0.02653777,0.03826634,-0.00063959224,-0.02965997,-0.036833245,-0.018467898,-0.006268565,-0.104010284,-0.03422348,0.00757713,-0.01815764,0.11226156,-0.0014801433,0.00037698515,-0.07664837,-0.009718456,0.0769892,-0.026392277,0.060456418,0.07767686,0.01946222,-0.020196509,0.10075332,-0.035795853,-0.005284978,-0.032889206,0.038311977,-0.032552704,0.048441466,-0.05082019,-0.109090365,-0.0182819,-0.003055114,-0.044004213,-0.04097405,0.014275565,0.042103287,-0.032295175,-0.098865405,0.0042893756,-0.04911728,0.07355828,0.048142295,-0.043657117,-0.054483403,0.08358796,-0.019084854,0.03843643,0.053116895,-0.115440845,0.07346352,-0.060084324,0.01462431,0.0039487327,-0.0012733965,0.051165607,-0.06561447,0.06564262,0.10553977,0.11254935,-0.036770336,0.008488047,-0.006314502,0.037509892,-0.06131596,-0.116519205,0.078884065,0.038650785,-0.011941659,0.05655096,0.059142087,0.06889689,0.03459866,0.0010948305,-0.0855851,-0.03504748,0.009203746,0.021559037,-0.078189865,-0.07734249,0.056678914,0.038344402,-0.07340768,-0.0313547,-0.02473527,-0.0050344774,0.05448519,-0.026877392,0.07965928,0.036691144,-0.08782333,0.09884669,0.011669429,9.09978e-34,0.09379143,-0.014786203,0.050967917,-0.05562932,-0.062459655,-0.030987222,0.040737174,0.020908233,-0.00474911,-0.024300436,0.018668834,0.07677438,0.04266124,-0.011864124,0.03736296,-0.07390338,-0.030256743,0.02680398,-0.03641222,-0.010041253,-0.0068953633,0.017197657,0.012043182,-0.017388817,-0.06537933,0.030606989,-0.013248579,0.11148511,-0.0037791512,-0.0038322737,-0.04599734,0.045190588,0.026316617,-0.052492004,-0.12849101,0.013842138,-0.001377666,0.02204627,-0.02434717,-0.02048185,0.02148316,0.05426643,-0.00066394167,0.029828126,0.0023560436,0.08964947,0.07035457,0.031292062,0.05259293,-0.022345854,-0.013786904,-0.023737647,-0.00528866,-0.05440034,0.04104814,0.05968195,-0.052297533,0.00026277336,0.017660666,-0.07680112,-0.028754553,-0.05293793,0.11576262,-0.06234727,-0.031162305,-0.039723366,0.034953114,-0.048739545,-0.03819359,0.038779493,0.08472971,0.039643586,-0.0079157,-0.019283619,0.014212346,0.010139841,-0.02628518,-0.026324965,-0.021514157,-0.009125139,-0.026993547,0.031857602,-0.032068294,0.008659067,0.090983294,0.05961087,-0.0037248333,-0.005051623,0.029659852,0.024851628,-9.208483e-06,-0.008780529,0.009063283,0.032317992,-0.054022122,-3.5241804e-08,0.041188143,-0.07058289,-0.009252691,-0.07986751,0.0071317265,0.06964108,-0.09024951,-0.0019861034,0.12544529,0.041784227,-0.007504155,0.071826175,-0.03025709,0.053224523,0.08179403,0.08524439,-0.011383083,0.024355454,-0.009862474,-0.06544933,-0.047267355,-0.034968123,-0.06046418,0.06576347,0.04030873,-0.05736162,-0.00049865653,0.022815326,-0.033735633,-0.0791995,0.007370066,0.04229389,0.0052678687,-0.0094897235,-0.00889809,0.030123029,-0.015520731,0.011337573,-0.041298267,0.06973884,0.057940792,-0.05440377,-0.09481076,-0.0021311599,0.08324241,0.05455472,-0.07470367,0.078418694,-0.037521344,-0.016518407,0.045916587,-0.013061321,-0.004646725,-0.007496973,-0.062878005,0.011789943,-0.058079872,-0.03568048,-0.0031249996,0.04274642,0.029388797,0.019247776,0.11109799,0.0008137895 +7.2.4.1,"The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 7.2.4.4, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC 7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)] and EC 7.2.4.3 [(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)] [2]. ",384,1.0,-0.08183714,-0.06350798,-0.04442016,-0.008877907,-0.015590991,0.025360039,-0.027378473,-0.013588031,-0.022654884,-0.02498112,-0.022947332,-0.056487083,-0.07786794,0.06592532,-0.03896296,-0.022801468,-0.07482692,-0.008024617,-0.017537199,0.027105551,0.1251231,0.058971412,-0.09868298,-0.024458619,0.05698634,-0.00093081396,0.03910113,-0.031422284,-0.031101994,-0.093621336,0.0013236625,-0.053209618,0.0841262,-0.021412933,0.0264772,0.092108265,-0.08827722,-0.0553491,0.0706482,-0.0083213765,0.037279498,0.061409272,0.06573169,0.012184475,-0.025447024,-0.03834891,0.031355314,-0.03559278,0.11536969,-0.07241404,-0.038836297,0.01799507,-0.04611274,0.036769703,0.01479534,-0.020650435,0.02523986,-0.058282327,-0.058690123,0.015450738,0.09137435,0.076351665,0.03754568,-0.07529705,0.01244387,-0.06341485,0.003210156,0.009046697,0.02809607,-0.012393114,-0.07860957,-0.048302732,0.041642,0.045078736,0.01325494,-0.013281776,-0.030023698,-0.007087153,-0.009132471,0.0013034105,-0.017782405,-0.045854565,-0.0040127216,0.05762411,0.020696873,-0.076080464,0.039500713,-0.016000552,0.06669499,0.08032054,0.0746648,0.03895211,0.043289162,-0.026782561,-0.003554138,-0.016412,0.019313794,0.040096894,-0.036263302,-0.02057599,0.048166282,0.048305508,0.008497372,-0.07940794,0.0059523676,-0.025113756,0.055283893,0.08483187,0.0018859124,0.041588027,-0.004482901,0.05084492,0.035871312,0.025229484,-0.0057768123,0.07513336,0.0032790494,-0.058979955,-0.0031579102,0.031266097,0.02037381,-0.01836488,0.0033861753,0.032739718,-0.019355081,0.04798147,-0.16376545,2.976636e-33,0.024097366,-0.064393155,-0.05779631,0.012740805,-0.07822119,-0.044062633,-0.108161375,-0.017358607,0.013226961,-0.05290583,-0.05066929,-0.023033176,0.05261199,0.018025476,-0.106371045,-0.034903936,-0.069878034,-0.018921457,0.07142044,0.026682151,0.008094253,0.080456115,-0.055451997,0.020166485,0.035315674,0.009704613,-0.015840173,-0.056807637,0.019318253,-0.0055217566,0.040623292,-0.073808104,-0.09730036,0.028113948,0.04698943,-0.003691029,-0.01563883,-0.016521107,0.0025317424,0.043185484,0.09734214,0.03537595,0.007427024,-0.007114681,0.044344455,-0.005305271,-0.06408575,0.08957683,0.04605728,0.011027376,0.0022486108,-0.07527034,0.014651655,-0.038641207,-0.012340092,-0.041527648,-0.024598597,0.07731282,0.053893853,0.051759962,0.07678381,-0.0069992114,-0.025707986,-0.00814656,0.06286917,0.03955917,-0.054339807,-0.062055852,0.055023804,-0.013662414,-0.1014371,-0.02802652,0.10766967,0.054210253,-0.006062732,-0.04021666,-0.089878894,0.0294345,0.0037163387,0.00876213,0.016442638,-0.023567816,-0.012713732,-0.057043903,-0.036392123,0.014326385,0.016810551,0.017951284,-0.03797649,-0.0104651395,0.054463133,-0.020788329,-0.049557935,0.015337851,-0.062287193,-3.629806e-33,0.11448632,-0.07114197,0.054510377,-0.024244478,-0.01687595,0.063556656,0.053575397,0.0078908065,0.0015634353,0.014584737,0.06820536,-0.0046849297,0.10196306,-0.021658909,0.08948906,0.0055427523,-0.0035131946,-0.020422256,-0.020866837,-0.025260802,-0.08494035,0.09136286,0.029987475,0.012339618,0.0005214405,0.0030305174,-0.049336866,0.09193197,0.010070176,0.02898204,0.039625786,0.03817744,-0.07230526,-0.047658954,-0.1527283,0.022901952,-0.049274143,-0.04256094,-0.00016567163,0.008435816,0.07428273,0.041709617,-0.010294804,0.06941536,0.01968911,0.0039451523,-0.017752348,0.0057291803,0.039251927,-0.038348716,0.06419492,-0.060245674,0.0027243984,-0.03290879,-0.019402698,0.07164982,0.0064932057,0.011495352,0.04435305,0.016581362,-0.027877437,-0.02573918,0.036891945,-0.16102463,-0.032297254,0.046786766,0.019754494,0.03229991,0.0468718,-0.056944784,0.10588125,0.06346349,0.012319918,0.013733871,-0.013846453,-0.0062334696,-0.08075618,0.0027157804,-0.02599369,-0.053872485,-0.031137843,0.0578486,-0.036625907,-0.07203781,0.07063657,-0.017552247,-0.00040645516,0.060589142,-0.014747946,0.007228379,0.016116882,-0.11488327,-0.04751631,0.09442603,0.04500206,-4.4471548e-08,0.057130884,-0.03362459,-0.011945127,-0.017202513,-0.008990069,0.12120833,0.019559035,0.03936855,0.027066557,0.030440442,0.06128906,0.02436961,-0.05941148,0.09326624,0.023754423,0.07868231,-0.087219656,0.06730257,-0.017747916,-0.032109305,0.05802444,-0.069460586,-0.12740283,0.10098091,0.0029701653,-0.030591384,0.0053657778,0.011030108,-0.010886898,-0.08007789,-0.0075461767,0.06329882,0.046763785,-0.005269034,-0.08738332,-0.05523707,-0.023044027,-0.036643438,-0.012945289,0.0762585,0.059353378,-0.025503954,-0.105468765,-0.025605138,0.0010368155,-0.006399826,-0.016919876,0.07805932,-0.031607375,-0.016628146,0.12678954,-0.006982268,-0.045959406,0.016170226,-0.014886052,-0.0049657603,-0.085015625,-0.036875974,0.016370485,0.10056616,-0.021170067,-0.012740582,0.06432537,-0.06652392 +7.2.4.2,The enzyme from the bacterium Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+. Differs from EC 4.1.1.112 (oxaloacetate decarboxylase) for which there is no evidence for involvement in Na+ transport. ,384,1.0,-0.051283777,-0.03803374,-0.014196377,-0.02122927,0.028957881,0.007872562,-0.0045220125,-0.026638286,0.020150349,0.025653288,0.0025025003,-0.10028853,-0.004190497,0.048276886,-0.05094447,-0.0057682544,-0.09128176,0.0051636808,-0.032911997,-0.021166695,0.09738545,0.058152337,-0.05494936,-0.024422029,0.035383467,0.013932157,0.016941246,-0.063698046,0.014374093,-0.09465472,-0.026620911,0.0071231127,-0.0062854625,-0.0065542385,0.05642976,0.054538906,-0.061965697,-0.041905917,0.021649726,-0.0026141843,0.015562546,0.028345468,0.056493923,-0.00950528,-0.07508464,-0.03347616,0.048079394,-0.06572352,0.060874645,0.035782434,-0.040191237,-0.06336202,-9.465346e-05,0.022738231,0.03132512,0.032892797,-0.10568146,-0.07024922,-0.03079463,-0.0153655,0.053829685,0.016572693,0.0042007514,0.00061543717,0.03496252,-0.018565904,-0.04765782,-0.011170032,0.043087654,-0.07497485,-0.01884831,-0.101782836,0.010993484,0.058567107,-0.043193467,0.004421761,0.022118898,0.0066849124,0.044148885,0.010206439,0.0012433548,-0.017648773,0.009061572,0.010848685,0.029572068,-0.015953343,-0.0037633828,-0.0013849904,-0.058495317,0.00993607,0.08477786,0.0034507392,0.061469376,-0.01132387,-0.0052430043,-0.012029216,-0.028550014,0.0578715,0.010667806,0.0021746014,-0.0008604312,0.10812702,0.023753338,-0.038692016,-0.044700485,-0.10107169,0.06464072,0.06532278,-0.007218416,0.060361788,0.0070116264,0.029823922,0.029168526,0.04017455,0.028678374,0.08523712,0.05159271,-0.13019888,-0.04791836,-0.0263657,0.012546764,-0.05578506,0.008885718,0.010532631,-0.010306968,0.070325114,-0.0977234,3.4178082e-33,0.043930594,-0.034898523,0.00826679,-0.005836723,0.007888293,-0.025571292,-0.090281874,-0.03711211,0.05070607,-0.11722527,-0.15149182,0.000962757,0.020879019,0.043190524,-0.021971732,-0.04171924,-0.087161124,-0.04507889,0.101412974,0.038084168,0.03936013,0.030284183,-0.03334931,0.05704568,0.011538423,0.020488137,0.0003877854,-0.06389748,0.0638246,0.018356266,0.04667875,-0.11494787,-0.10739236,0.057695247,-0.0022070052,0.0358263,-0.04603115,-0.009768222,-0.006789858,0.07239877,-0.029078044,-0.017367702,-0.04841957,0.0077828877,0.048924264,-0.07985883,-0.08870073,0.05319174,0.008927287,0.019445518,0.04358558,-0.00806037,0.07819847,-0.055270117,-0.052525915,0.1050303,0.029829666,-0.027496198,0.00012955123,0.038876254,-0.0012323464,0.08301633,0.008592895,0.058798227,0.09064348,0.040079586,-0.1111852,-0.0687496,0.014346823,0.05650124,-0.030927617,-0.04262238,0.084780164,0.013554284,0.013692018,-0.058270834,-0.09413025,0.0077597736,-0.0307156,0.037024975,0.023496324,-0.019545376,0.037656948,-0.02266484,-0.049850192,-0.05615119,-0.004232832,0.002513164,-0.004287496,0.014318039,0.062304035,0.010500366,-0.089332916,0.01894854,-0.009062515,-4.9695353e-33,0.14351544,-0.062302805,0.02578385,-0.035868384,-0.026596077,0.105437435,0.08081007,-0.00075187924,0.034585167,-0.007392008,0.10167362,0.029790582,0.064593434,-0.033117086,0.05904007,-0.05327387,-0.017818663,0.06580567,0.0057679913,-0.05911811,-0.024826331,0.029867647,0.032305215,-0.013214098,0.023974681,-0.00092990743,-0.02670515,0.10697613,-0.043684762,-0.034811046,0.010805999,0.072552286,-0.025172247,-0.07126719,-0.09478917,-0.007851996,-0.024947058,-0.018375557,-0.0043098605,-0.031157896,0.0036430024,0.054421123,0.014544846,0.06575634,0.04518313,-0.015548333,-0.05767553,-0.052312676,0.03874053,-0.14057896,0.03822756,0.039045442,-0.03221928,-0.037574355,0.054711346,0.09529615,0.026551316,0.012966576,0.050845306,-0.002648674,-0.050851412,-0.0682921,0.05509159,-0.087109804,0.0026091316,-0.027421419,-0.00025288662,0.043124802,0.05642133,-0.017679116,0.043055415,0.027061153,0.025806297,0.032010518,-0.01528447,-0.04630507,-0.053251635,0.031559788,0.03810102,-0.08592898,-0.050680596,0.023939405,0.025701202,-0.06581374,0.07928379,-0.07606657,-0.0060482356,0.058420584,0.013807424,0.049866367,-0.04467453,-0.10176222,-0.08187412,0.04084467,0.006663784,-4.4377806e-08,0.028740896,-0.06651353,0.007700753,-0.040305074,-0.004631742,0.12855354,-0.03311391,0.0050818385,0.07829595,-0.044413008,0.056722388,0.05814177,-0.05999948,0.078631386,0.0060443743,0.053717453,-0.039257087,0.03295838,-0.009429595,-0.007979488,-0.016859246,0.00016908914,-0.10346886,0.13180017,0.02429707,0.038560733,0.017062945,0.0642879,0.027996104,-0.0793161,-0.11351838,0.068077944,0.057113543,-0.04676177,-0.079127684,0.0053879204,0.026859412,-0.0041368185,-0.07109857,0.020064631,-0.02393658,-0.030124275,-0.038395036,-0.033182923,0.005501253,0.005989411,-0.009327507,0.087829694,-0.027075397,-0.05816524,0.056432,-0.018626692,-0.03569857,0.00295637,-0.07895732,0.016845195,-0.08443679,-0.11996709,0.0010058901,0.0044894107,0.024282208,0.023842538,0.096133955,-0.02944438 +7.2.4.3,"This bacterial enzyme couples the decarboxylation of (S)-methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis. It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity.",384,1.0,-0.11298365,-0.0033636605,-0.027592668,-0.0022026908,0.009649522,0.03534862,-0.054732326,-0.0023363954,0.022507627,0.0359208,0.008497596,-0.069702454,-0.014248417,0.08552105,-0.046039086,-0.065803215,-0.051963285,0.08428001,0.04315514,0.012410018,0.103801295,0.055103425,-0.0043043657,0.000721262,0.03050861,0.045481693,0.056867875,-0.012722962,0.02008053,-0.08080285,-0.032878704,0.0029165254,-0.0052399435,0.00032802887,0.0134513965,0.073305674,-0.09714606,0.0011644296,0.017653143,0.020234251,0.05732446,0.0016788878,0.059709944,0.0023879227,-0.034048025,-0.08314733,0.023639435,-0.02148073,0.096630275,-0.010813556,-0.0463722,0.010174457,-0.042190082,-0.033156645,0.02082371,0.035412136,-0.03817203,-0.035490956,-0.011099502,-0.03876218,0.09917564,0.02307294,-0.010174603,0.02293309,0.05884768,-0.09726153,-0.021686886,0.02417979,0.07151398,-0.032174863,-0.027643371,-0.051505603,0.016851397,0.032209035,-0.0060297013,0.0018591117,0.013675031,-0.037204284,0.008469493,0.0054741413,0.02991535,0.01639439,-0.02011699,0.057679426,0.037319697,-0.0077359998,0.022659738,0.0063220738,0.01961446,0.030066557,0.05370934,0.02415867,0.066444784,-0.026938075,-0.08085891,0.015853083,-0.055502627,0.01183199,-0.014218905,0.018333929,0.062195506,0.122077405,-0.038040183,-0.03260542,0.03601612,-0.040453836,0.028618803,0.063812524,-0.010836354,0.08986755,0.02343457,5.4296295e-05,-0.0027186081,0.011654117,-0.009483722,0.09581942,-0.02138389,-0.05182969,0.0031173362,0.0055475407,-0.01107225,-0.12763357,-0.097093746,0.040400933,0.0013033177,0.021523083,-0.12842855,1.0587382e-33,0.029491061,-0.03997345,-0.008428974,0.0050820173,-0.019457338,-0.074922286,-0.045679353,-0.043420594,-0.059765477,-0.079745166,-0.073513046,0.015891094,0.033298183,0.06935874,-0.07765365,-0.06900467,-0.0656472,-0.02080369,0.08832898,0.0012810482,0.029231941,0.051816616,-0.014843518,-0.0060647028,0.015994012,-0.03072556,-0.04403841,0.015488475,0.077729225,0.00915922,0.002011569,-0.11430493,-0.076718695,0.037267044,0.053619154,0.005715537,-0.040267628,-0.040487204,0.03683711,0.11788526,-0.056194533,0.021032006,-0.0392797,0.025697215,0.023265058,-0.02182014,-0.07562452,0.091845855,-0.010963049,0.062064208,0.0820899,-0.08101978,0.053098865,-0.058785766,-0.085400485,0.04167091,-0.053436086,-0.022549003,-0.022269312,0.05129262,0.071306504,-0.008680392,-0.062003464,0.057471987,0.08054191,0.07031407,-0.06318487,-0.09850884,0.055639043,0.029974489,-0.095075496,0.002009095,0.05911736,0.012429289,0.023697762,0.041519742,-0.08152033,0.0058820257,0.049119163,0.030918745,-0.007801081,-0.024988553,-0.0048289984,0.014228083,-0.013121399,-0.014073639,-0.009296625,-0.035149638,0.021378485,-0.008539643,0.12896918,-0.06664458,-0.025931595,0.023887692,-0.021429494,-2.3637024e-33,0.05951595,-0.092196345,0.036759652,-0.04834468,-0.06929976,0.03325825,0.026403395,-0.08987217,0.0035091469,0.0040209875,0.06316974,-0.016797489,0.06612168,0.00012808685,0.020677721,-0.053362273,-0.01594057,0.0023146574,-0.024153158,0.010775171,-0.019380894,0.068113714,0.032311186,0.0013059916,0.026577502,-0.04440033,-0.056715198,0.056912214,-0.04890336,0.0537043,-0.026157998,0.00415009,-0.07979187,-0.063349836,-0.085832424,0.07618637,-0.05957389,0.052742984,-0.011485927,-0.01174906,-0.0052674753,0.031623628,0.030507615,0.0054143625,0.052817374,0.0060465084,-0.030737875,-0.013061835,0.024638643,-0.092330255,0.028536294,0.021348733,0.027772993,-0.006575087,-0.0018807969,0.06849017,0.006579378,0.014654964,0.105067976,-0.05403907,-0.0062575373,-0.085015744,0.010428536,-0.12987353,0.043991,0.038274787,-0.0108375,0.013831873,0.010686802,-0.077108845,0.10399378,0.074792616,0.07994814,0.046286594,0.0013035102,-0.071798116,-0.024259537,-0.08092274,-0.02715458,-0.009671296,-0.040025312,0.076615885,-0.058902506,-0.087796465,0.0133646475,0.015493338,0.03898489,0.10710261,-0.006882496,0.040759705,-0.020093618,-0.04247994,-0.04585368,0.07866794,-0.041904718,-3.8863504e-08,0.026276978,-0.05063207,0.009220245,-0.06332805,0.029156541,0.1352051,0.0066210497,-0.06255088,0.09251506,-0.015088343,0.03794223,0.1046434,0.0035547884,0.050609425,0.026690166,0.057992883,-0.009777177,0.062730454,-0.026943335,-0.09112959,-0.00041104847,0.0024270734,-0.14621742,0.09048099,0.0904615,-0.010312718,0.02969831,0.050433487,0.01686049,-0.09711023,-0.039692227,0.022435354,0.026827171,-0.0006076907,-0.07683912,0.0071918345,-0.032547154,-0.0037969,-0.04215482,0.037963428,0.011337099,-0.004803773,-0.048267234,-0.0018602542,-0.0041988087,0.04093231,0.010528438,0.09926086,-0.057703108,-0.010096421,0.04366936,-0.056035545,-0.065789014,-0.026846804,-0.023142843,-0.047567155,-0.05981301,-0.08614842,-0.035782784,0.0147260735,0.023801716,0.018819682,0.12288851,-0.03493815 +7.3.2.1,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of phosphate anions. Unlike P-type ATPases, it does not undergo phosphorylation during the transport process.",384,1.0,-0.09071719,-0.07758976,-0.0023498542,-0.033335865,-0.10992866,0.015794884,0.0804168,0.06768944,0.063627645,-0.05379532,0.015563822,-0.029941645,-0.0030655947,0.11890168,-0.02793873,-0.050241757,-0.057320997,0.01553558,0.0577388,-0.027672237,-0.006068077,0.08730633,-0.04008706,0.023744076,-0.080962114,0.022888994,0.017932378,-0.038391806,-0.0412107,-0.017985981,-0.102431014,-0.0007263459,0.048402645,0.012857714,0.034914408,0.10467998,-0.016442958,0.0067527243,0.07189732,0.008722225,0.116574824,-0.001136636,0.08732598,0.063246064,-0.12907735,-0.016070884,0.05241332,0.033866603,-0.017136436,-0.039146002,-0.040693235,-0.017292071,-0.04927805,0.020935927,-0.015899109,0.031218085,0.0043683555,0.0005299862,-0.020594012,-0.07045061,-0.012055691,0.0042441455,0.09157095,0.108360425,0.035373095,-0.057691973,-0.015302357,0.023685133,-0.023218818,-0.015632477,-0.0831401,-0.070216,-0.046313375,0.05611271,0.049727533,-0.04206099,-0.02502308,0.016608486,-0.042721026,-0.026380293,-0.0059228577,-0.04197195,-0.025740033,0.033484727,0.035939686,-0.04536573,-0.0008222906,-0.0070129335,0.029351324,0.011714333,-0.033604573,-0.04966916,0.03651035,-0.045866527,-0.10637753,-0.031852856,-0.010881491,0.018070057,0.016784044,-0.018049808,0.047068097,0.060172014,0.0471743,0.0036739176,0.028003938,-0.016175408,-0.024630291,-0.0021966025,0.025341053,0.01905283,-0.0339242,0.013231167,0.018644648,-0.08299914,-0.017035814,0.055643093,-0.02756778,0.018780423,-0.027548417,0.015416914,-0.06917923,-0.13116238,-0.007098343,-0.040291887,-0.015166601,0.016900128,-0.09115921,4.304643e-34,-0.07535131,-0.058006432,0.032725632,-0.021139504,-0.0025385318,-0.035549697,-0.0010629685,-0.06182578,-0.029362408,-0.09410557,-0.006067612,-0.003259657,0.012203537,0.10672729,-0.007670545,-0.015056638,-0.101374045,0.08027684,0.096578196,-0.02410803,0.045695484,0.05443299,0.012855603,-0.02386834,0.11048361,0.00903741,-0.02837237,-0.011218265,0.051813416,-0.015233458,0.03033217,-0.04091219,-0.098902784,-0.026342511,0.03132034,-0.087654844,-0.04416739,-0.00307299,0.04349814,-0.060167972,-0.1135105,-0.029392455,-0.05858049,0.06407816,0.04452759,-0.035215814,-0.014139976,0.05949366,-0.0442457,0.03883073,0.0643791,-0.1336725,0.06484587,-0.06762235,-0.01915277,-0.0074905087,-0.01581769,0.060351614,-0.044213433,0.06744868,0.101786636,0.13625784,-0.03755238,0.011988052,0.014907354,0.03707777,-0.046796277,-0.12018328,0.068523884,0.12011642,-0.0021195952,0.036060125,0.0464451,0.061143573,0.027697146,0.007689717,-0.07560921,-0.06333932,0.009760211,0.028706295,-0.04512489,-0.08753819,0.060404412,0.005819893,-0.07822856,-0.055544596,0.0014448956,-0.012187821,0.014488541,-0.056021165,0.15229785,0.045731768,-0.07708231,0.099018574,0.02533983,-1.7540666e-33,0.09158692,-0.025106346,0.07760652,-0.045184206,-0.051446628,-0.02091604,0.03792882,0.011579816,0.013371869,-0.03728645,-0.017152518,0.061428115,-0.007987749,-0.022804977,0.010970258,-0.07269664,-0.01194097,0.036250085,-0.044665035,-0.021063019,0.034368455,-0.01333709,0.011243293,0.028144965,-0.09954635,-0.005722432,-0.05540482,0.0658365,-0.012675862,0.0127652995,-0.026480967,0.05638316,0.0026440169,-0.07303973,-0.07820146,0.031433366,0.018466197,0.040841762,-0.03263965,-0.0058756154,0.052660257,0.061593477,0.021315664,0.03321086,0.0029805403,0.07179464,0.018238822,0.062580094,-0.0013786595,-0.028951537,-0.0042743385,0.0015945558,0.017714225,-0.007562303,0.050020747,0.07918178,-0.032913968,-0.015212289,0.044668995,-0.07132447,-0.057105802,-0.09531068,0.089428864,0.0134242065,-0.0014007232,-0.018618481,0.03888774,-0.08103015,-0.029837694,0.069950424,0.07822525,0.03566762,-0.023621023,0.012585037,0.038229894,0.027437374,-0.015462486,-0.054214276,-0.044374365,0.020885408,-0.06378999,0.052636117,-0.0241106,-0.00088986295,0.09333964,0.018899288,-0.00053921883,-0.013021918,0.009314166,0.033284772,0.034108512,0.0034247823,0.013087114,0.048116058,-0.038283538,-3.5488107e-08,0.022620223,-0.039133344,0.026347736,-0.05900011,0.037242383,0.025560906,-0.03021928,0.020193841,0.12286312,0.04419015,0.0133533515,0.07204122,0.0068855747,0.03358024,0.0929681,0.07351323,-0.03637356,0.005149175,-0.018151721,-0.054267276,-0.015016799,-0.027190391,-0.056396984,0.06898922,0.08538777,-0.013181671,0.00057088886,0.039986648,-0.035002146,-0.05323877,0.03962235,0.024310196,-0.026898043,-0.0037671016,-0.027773138,0.021967141,-0.031156527,-0.01921432,-0.08117431,0.08094944,0.023623608,-0.044541314,-0.0726365,0.018549502,0.07349774,0.07008168,-0.06962246,0.047639582,-0.056239184,-0.019267192,0.05792948,-0.006488185,-0.027876643,-0.027458936,-0.073446296,-0.007332195,-0.044595726,-0.023002626,-0.02380729,0.012152917,0.049164794,0.023011599,0.11458335,-0.016400477 +7.3.2.2,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of phosphonate and organophosphate anions.",384,0.99999994,-0.11282367,-0.04432277,-0.016684845,-0.04010543,-0.10836852,0.031830996,0.058723338,0.0641863,0.05726977,-0.050690487,0.026155073,-0.07236854,-0.0047477325,0.09547313,-0.024170743,-0.048227064,-0.07343346,0.029225713,0.030420106,-0.028085781,-0.012710485,0.11816187,-0.033444375,0.0151321925,-0.07671793,0.043027773,0.004803664,-0.03496148,-0.0131670805,-0.024742013,-0.08014291,0.0022684755,0.058124237,-0.009089029,0.0048177927,0.10480424,0.002096891,-0.01685225,0.08136418,0.018574921,0.12120033,0.01476539,0.09129571,0.06425205,-0.14239018,-0.02014033,0.044488918,0.030435853,-0.010171078,-0.016583273,-0.024666011,-0.02331255,-0.04094259,0.05252254,-0.013487337,0.06763022,-0.0020048537,0.011338468,-0.026726363,-0.055319503,0.013865536,0.00048695682,0.079128,0.10287137,0.027596632,-0.05769808,-0.02696568,0.019827375,-0.010033321,-0.020190485,-0.09046774,-0.078602344,-0.03945265,0.0682767,0.04669966,-0.012374814,-0.013816103,0.004339168,-0.02669762,-0.026029836,-0.0068040844,-0.041634347,-0.017630957,0.023987608,0.027476622,-0.032931447,0.004552237,0.001773527,0.006529151,0.004632678,-0.031389385,-0.060706604,0.041711126,-0.060919676,-0.11173605,0.0004694707,-0.011711671,0.038580306,0.02575569,-0.0132038575,0.064097084,0.06635507,0.051449683,-0.02009494,0.011526226,-0.033691525,-0.044595078,0.012940568,0.0032707881,0.0010820781,-0.03080478,0.019711064,0.012485975,-0.083692394,-0.0033384226,0.05999248,-0.02111531,0.009238683,-0.015824495,0.015778298,-0.07002884,-0.13609514,-0.011783385,-0.03764519,0.0062751663,0.008242679,-0.09377156,-2.2829175e-34,-0.0722148,-0.058401834,0.0432377,-0.0033429228,0.005914923,-0.047901668,-0.005998512,-0.04752827,-0.022817655,-0.088893846,-0.004052055,0.012738458,0.013824782,0.103944175,-0.011368752,-0.00083115895,-0.108507425,0.07855072,0.08985867,-0.030452812,0.04231559,0.068404175,0.03510437,-0.040555973,0.11542482,0.017711744,-0.031873718,-0.039916623,0.06977958,-0.021065272,0.010850617,-0.03546076,-0.101067625,-0.020164987,0.043808084,-0.058705717,-0.055407442,-0.018334297,0.025100688,-0.04999549,-0.09256671,-0.034766834,-0.07583059,0.077776015,0.047751226,-0.038837984,-0.03849823,0.037203897,-0.008136589,0.018635698,0.059047762,-0.1356659,0.064100035,-0.058134522,-0.0024950372,-0.013859801,-0.025545992,0.04097244,-0.056245964,0.06530937,0.09144419,0.12454557,-0.037521187,0.03760073,0.04204118,0.034146674,-0.067086264,-0.1262761,0.06070359,0.10538087,-0.0014186545,0.018272113,0.034144044,0.06904487,0.023611164,0.021884587,-0.08087921,-0.0791369,-0.0035522897,0.021687858,-0.03496265,-0.08460828,0.051461447,-0.0018708393,-0.08136158,-0.05337992,0.0071525984,-0.03779769,0.026165618,-0.05947734,0.14526747,0.055436708,-0.099158764,0.08273959,0.01683706,-1.9632249e-33,0.10315558,-0.02220944,0.0667451,-0.045374148,-0.053776048,-0.0034106504,0.026329285,0.010094269,0.013448554,-0.023200938,0.0021905021,0.06623964,0.018530147,-0.018788178,0.02121488,-0.06361535,0.0034633258,0.019264022,-0.029069075,-0.021862594,0.026189053,-0.0027715347,0.017240243,0.044364013,-0.09487228,-0.0155222025,-0.047405068,0.046409022,-0.014565848,0.03075827,-0.03989734,0.03812307,0.0061281505,-0.08393358,-0.06033199,0.03408371,0.016742995,0.03154833,-0.021740124,-0.009637931,0.035330825,0.055384524,0.019893833,0.03560801,0.0079572955,0.06166503,-0.006397053,0.07209021,-0.02080156,-0.025278868,0.017385704,-0.011596587,0.004150735,-0.017765809,0.053408843,0.090114646,-0.05082654,-0.031013655,0.06135457,-0.055184003,-0.05780648,-0.07687805,0.06781642,-0.0059157982,-0.0051679225,-0.011616464,0.04397217,-0.07401886,-0.041289352,0.060840447,0.09873215,0.039178476,-0.024979502,0.024201246,0.03346606,0.034348994,-0.026122723,-0.06595579,-0.06355664,0.020988176,-0.058650646,0.04479125,-0.013682938,0.003030938,0.08987078,0.009609947,0.007629367,-0.0073832218,0.0051180082,0.031662118,0.028548425,0.017853945,-0.01935519,0.066034056,-0.03299645,-3.58813e-08,0.019002913,-0.03820655,0.024500903,-0.072843865,0.0019137866,0.0281003,-0.030023934,0.014580506,0.11441968,0.06492523,0.019407952,0.070559844,0.01928562,0.044711202,0.07212342,0.07970034,-0.046830177,0.013448549,-0.031553928,-0.07123695,-0.017216941,-0.02520409,-0.02617964,0.061910376,0.08616775,-0.029250877,0.014405643,0.048346907,-0.012998057,-0.050796036,0.03890513,0.02618641,-0.016765349,-0.0014001526,-0.046112746,0.044445734,-0.03438571,-0.026681451,-0.08775132,0.07114569,0.01173312,-0.02955226,-0.097386695,0.017790113,0.07242077,0.051429644,-0.060466386,0.07529683,-0.060884785,-0.021318844,0.030468011,0.006459885,-0.0047835903,-0.0340265,-0.07931387,-0.014983286,-0.06285193,-0.014581156,-0.028616829,0.015972434,0.018296555,0.031298753,0.116497,-0.029429337 +7.4.2.1,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of polar amino acids. This entry comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline.",384,1.0,-0.100664444,-0.07287125,-0.037951607,-0.031833272,-0.07621939,0.031617124,0.02863574,0.067193754,0.057237905,-0.07562129,0.059142686,-0.061444703,-0.007044155,0.11657017,-0.002394872,-0.038097646,-0.07985155,0.0077891364,0.034998044,-0.027859436,-0.017174551,0.121089324,-0.05556883,0.0048225396,-0.070692234,0.03998186,0.019449538,-0.038732667,-0.005419164,-0.04333928,-0.06589875,0.0032825805,0.046614926,0.02170854,0.02373863,0.09511032,-0.010245465,-0.01853125,0.090947054,0.04640099,0.09658219,0.0030817436,0.07547654,0.037052177,-0.13033804,-0.017278835,0.062078744,0.026934596,-0.00314194,-0.0419481,-0.034315854,-0.0329318,-0.050427794,0.041715626,0.0017991484,0.023708997,-0.0057842545,-0.0599591,-0.015995333,-0.056197677,0.023627931,0.021109909,0.08150389,0.08082999,0.021648446,-0.042668715,-0.04264217,0.018392533,0.011393622,0.004983504,-0.09297928,-0.09106149,-0.06687566,0.09761327,0.04348634,-0.028137168,-0.021432437,0.015478006,-0.0050128954,-0.058710825,-0.013687122,-0.028187154,-0.041581184,0.07173814,0.03977183,-0.04134742,0.019759744,0.022832125,0.010197185,0.0032469511,-0.01605554,-0.0713102,0.025834048,-0.059439823,-0.121823564,-0.008573929,-0.0064062322,0.013006753,0.016689567,-0.006894292,0.05119525,0.0399309,0.033929333,-0.008787572,-0.015716914,-0.027705412,-0.008309805,0.017765893,0.012668857,0.003823114,-0.04756794,0.01330188,-0.0062249014,-0.08732458,-0.026265144,0.068393596,0.009530125,0.011978238,-0.03744678,0.034926403,-0.07556623,-0.09852896,0.018357,0.0061209463,0.0056016487,0.0459605,-0.09880366,3.5624486e-34,-0.07226767,-0.048215095,0.038155727,-0.03718877,0.007886043,-0.037703697,0.0012923218,-0.05946678,-0.0020947268,-0.06957174,-0.022029618,0.01781167,0.012047545,0.1231678,-0.0062480457,-0.014506338,-0.1224076,0.06309826,0.09273096,-0.019574547,0.01944568,0.05771102,0.03239482,-0.039932527,0.116147,0.018787477,-0.0109870555,-0.028212413,0.053533856,-0.014820495,0.028094374,-0.0373994,-0.10684021,-0.014357229,0.051365126,-0.060414847,-0.048525695,-0.027032606,0.04016794,-0.040792458,-0.08808953,-0.023546131,-0.07185411,0.07090095,0.03534732,-0.028435243,-0.026969876,0.06458002,-0.033266768,0.023483032,0.060079716,-0.11545117,0.047056586,-0.08851692,-0.02482376,-0.022452911,-0.040133562,0.056395706,-0.038820587,0.060485423,0.09633308,0.12368198,-0.036933344,0.02181133,0.040831536,0.04211784,-0.061187804,-0.12175306,0.06938127,0.10296075,-0.030074293,0.024116646,0.041424047,0.059557177,0.02196746,0.013211809,-0.10407782,-0.055136986,0.035906382,0.014046886,-0.04921451,-0.08038662,0.05688668,-0.040879942,-0.07927717,-0.059276823,0.016361209,-0.043431345,-2.8404916e-06,-0.038918074,0.121109374,0.051906403,-0.08409337,0.091042824,0.011342048,-2.2359769e-33,0.083290465,-0.058815386,0.060563117,-0.046946798,-0.057917017,-0.003468083,0.013355793,0.010725788,0.0200627,-0.0077007753,0.01168188,0.06997009,0.03132195,-0.034676477,0.053773794,-0.068042494,-0.033127375,0.025647946,-0.026190238,-0.039689016,0.018398782,-0.013885896,0.01900591,0.040143624,-0.07407472,0.022315647,-0.033806216,0.07032177,-0.0029075535,0.022319373,-0.009251795,0.055539653,-0.008322375,-0.08216229,-0.06571802,0.040379338,0.035129067,0.049024787,-0.0133825205,-0.036392357,0.03407362,0.07075648,0.0056221317,0.061604124,0.0014914008,0.074973,0.001996942,0.045374602,-0.006764244,-0.04383831,0.0074674133,-0.027086709,0.0044497843,-0.014129213,0.04366505,0.09205591,-0.03358409,-0.020750422,0.054588042,-0.06910332,-0.06574937,-0.07352015,0.066214815,-0.0045518233,-0.000979386,-0.036756914,0.04084873,-0.082584284,-0.030225756,0.06128761,0.09031694,0.021195335,-0.027324295,-0.0025145842,0.030708633,0.041910086,-0.007985668,-0.054017287,-0.06756252,0.015344365,-0.061450206,0.034450002,-0.039860763,0.019477157,0.09044672,0.0031856657,0.007361935,0.04471822,0.015217635,0.046924997,0.021021906,0.029370056,-0.012946822,0.06485689,-0.0194429,-3.9764465e-08,0.01908641,-0.063107885,0.032891423,-0.03812653,0.0068552815,0.034193292,-0.049594846,0.02000824,0.09705117,0.053768378,0.03381349,0.09259494,-0.019787617,0.034895588,0.05977531,0.07448736,-0.042536654,0.0061342367,-0.004507243,-0.07770834,-0.022684205,-0.028035155,-0.026184302,0.07640026,0.064971924,-0.046033934,0.020424379,0.055886514,-0.0104305735,-0.059555005,0.047373537,0.043290365,-0.02283055,-0.0008743563,-0.042269025,0.021783808,-0.05289746,-0.034339912,-0.048160836,0.0766182,0.016848497,-0.014861843,-0.11243139,-0.006335865,0.07109448,0.046044987,-0.06850817,0.04635094,-0.06884526,-0.018944519,0.038036276,-0.0081299,0.002085488,-0.013586488,-0.075249374,0.011064506,-0.07187627,-0.042700194,-0.024551934,0.022172593,0.012727319,0.020580836,0.12525325,-0.010727447 +7.4.2.2,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein. This entry comprises enzymes that import Leu, Ile and Val.",384,0.99999994,-0.09270947,-0.052203413,-0.022924291,-0.052311976,-0.093087785,0.024020715,0.026588198,0.07000755,0.049853686,-0.08562423,0.034893613,-0.07671382,-0.009558565,0.10840131,-0.0026654664,-0.047725257,-0.07311814,0.02503943,0.036673702,-0.03385424,-0.010450139,0.11418399,-0.033428423,0.024154864,-0.08240242,0.028965348,0.01918694,-0.016429836,-0.008410291,-0.024985023,-0.0852404,-0.0019691372,0.036979467,0.013764467,0.011064703,0.06980817,-0.0144537045,-0.015336097,0.08965293,0.032010168,0.116031274,0.0032681783,0.08606971,0.0523671,-0.13080929,-0.030432608,0.04414112,0.016493412,-0.012266364,-0.014797057,-0.0146633275,-0.021102354,-0.057781786,0.062498126,0.005598256,0.031586114,-0.008959324,-0.016098643,-0.011223683,-0.05684736,0.022971923,0.010752057,0.092645325,0.103891805,0.018593354,-0.048182596,-0.046883747,0.030431239,-0.004956507,-0.017006088,-0.09021746,-0.096182816,-0.06461712,0.085546136,0.045597438,-0.026644966,-0.02112489,0.017440248,-0.022011677,-0.048609294,-0.015324143,-0.025776936,-0.023560558,0.038050894,0.029852571,-0.025438113,0.023664165,0.0041109393,0.026288142,0.0030525837,-0.0054224594,-0.069882125,0.026635988,-0.05236777,-0.09592374,-0.010594754,-0.0029553839,0.017545685,0.026587794,-0.0049692015,0.040630322,0.054889236,0.047642652,-0.013044974,0.0005131444,-0.01832666,-0.019685863,0.022991605,-0.015216203,0.0052576405,-0.019725429,0.006582905,-0.0027357622,-0.078891866,-0.012511684,0.04799243,0.0016192358,0.010475653,-0.009120082,0.017539758,-0.074886404,-0.12168324,0.017658126,-0.028789721,0.017498022,0.017824205,-0.10135889,-2.188962e-33,-0.08227745,-0.078826055,0.022472259,-0.008423117,0.008253738,-0.045591958,0.009725724,-0.026821777,-0.039554138,-0.071377665,-0.02508753,0.01571857,0.017455844,0.13667391,-0.009539569,-0.010094073,-0.0966863,0.05350631,0.08348772,-0.027852565,0.048900317,0.052006707,0.03731221,-0.06734751,0.09874735,0.022344448,-0.03128564,-0.013001221,0.07870933,-0.011859541,0.026833057,-0.04332164,-0.105317004,-0.013216644,0.03311789,-0.042329323,-0.032399192,-0.017587608,0.029769776,-0.040969573,-0.08266634,-0.039024346,-0.063649,0.053365633,0.051626965,-0.043550093,-0.008613862,0.05305353,-0.028405584,0.0026947628,0.057002347,-0.14323696,0.058914937,-0.08541031,-0.009402884,-0.005139753,-0.034519967,0.05774657,-0.048766665,0.07201965,0.079595745,0.13777833,-0.04341398,0.043917973,0.04665702,0.050059076,-0.07203961,-0.11470458,0.056629945,0.10218421,-0.012150008,0.03308126,0.03293201,0.05527149,0.04164615,0.013829921,-0.10067185,-0.07450911,0.008168931,0.040319733,-0.04686897,-0.09498124,0.03827937,-0.006805541,-0.0881808,-0.05368983,-0.005924528,-0.04150642,0.012841952,-0.0315715,0.13077247,0.055150524,-0.07933229,0.10526502,0.028451374,-4.488494e-34,0.09805155,-0.039837856,0.09584456,-0.043574084,-0.049813714,-0.014963715,0.029499864,-0.0039821025,0.022106592,-0.010618223,0.010762591,0.06772868,0.012361113,-0.042489737,0.04744844,-0.06269898,-0.03928881,-0.007079143,-0.031595897,-0.028708722,0.014623492,-0.015006364,0.011877711,0.015979879,-0.08583418,-0.0039229444,-0.023446208,0.08089677,-0.016438372,0.008945974,-0.0549966,0.032361146,0.010416108,-0.043469384,-0.07366744,0.026957339,0.014404132,0.02837517,-0.01865868,-0.022708762,0.025123624,0.061482593,-0.013988031,0.060343627,0.013062411,0.07459585,0.004961173,0.06383195,0.0094960425,-0.02823863,0.014746012,-0.020203114,-0.011762784,-0.0037042487,0.051054887,0.10155714,-0.035294604,-0.026151447,0.06608764,-0.06075405,-0.056664795,-0.06834037,0.07879571,-0.0011885228,0.013229789,-0.02891856,0.019265903,-0.07894888,-0.041462325,0.06683341,0.122612715,0.018558675,-0.026427759,-0.0034736884,0.0415825,0.031555943,-0.025115687,-0.067321315,-0.072919175,0.020972233,-0.058960743,0.024286108,-0.031243075,0.01846507,0.091707915,0.020254472,-0.020614935,0.009239456,0.008011394,0.03805083,0.021673659,0.031838585,-0.004760596,0.06681974,-0.040821828,-3.4070634e-08,0.0076209605,-0.05264967,0.015996408,-0.053521536,0.009373949,0.030210907,-0.04690891,0.019997409,0.11385886,0.08039669,0.015822448,0.08348521,-0.008901165,0.040698066,0.07163439,0.06420191,-0.030875338,0.0037969656,-0.01866656,-0.06380203,-0.015687559,-0.036218263,-0.020520313,0.055200964,0.06786494,-0.050284773,-0.013498448,0.06033427,-0.012015216,-0.05638566,0.04472503,0.030065572,-0.006752405,0.0076132133,-0.035582606,0.03450926,-0.045046553,-0.033432517,-0.065096736,0.070092045,0.054924,-0.06049861,-0.09152484,-0.0152297085,0.07762156,0.05327109,-0.05998965,0.06450133,-0.059652902,-0.015002538,0.036187455,-0.0030988797,-0.0015639337,-0.014688164,-0.0589641,-0.010750476,-0.06436096,-0.04429069,-0.015899489,0.029071826,0.017807005,0.030638445,0.1261718,-0.031583343 +7.5.2.1,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of maltose and maltose oligosaccharides.",384,1.0,-0.06641365,-0.063384436,-0.021897487,0.0040035048,-0.09137637,0.028196484,0.04570049,0.06604728,0.068379164,-0.095676124,0.02652381,-0.06109166,-0.036842704,0.07359616,-0.022086972,-0.06002311,-0.05792526,0.02456185,0.032230876,-0.039954044,0.029275483,0.107086584,-0.039945066,0.019728437,-0.07573895,0.03530618,0.012619543,-0.027822163,-0.01958405,-0.039055627,-0.08679969,-0.030746061,0.053637903,0.030085655,-0.00072340487,0.10549937,0.019536247,0.0012403134,0.07964893,-0.014444122,0.13010617,-0.028395256,0.09417306,0.07326294,-0.16899928,-0.0492276,0.016937755,0.023757981,0.004946568,-0.025511237,-0.049460877,-0.041456077,-0.062151797,0.05641266,0.033948217,0.049025536,0.005812708,-0.0009140574,-0.010361521,-0.053226724,0.017931096,0.042789456,0.094298095,0.09354435,0.017023863,-0.07167252,-0.04395552,0.0316731,-0.011716749,-0.013504129,-0.08349288,-0.07240847,-0.06725098,0.07560975,0.05259487,-0.033453576,-0.015912643,0.005556967,-0.034824662,-0.002589109,-0.008765313,-0.032457694,-0.0126186805,0.057846613,0.007209174,-0.05763449,0.036728118,-0.005107508,0.029846516,0.00028048095,-0.02138341,-0.07461835,0.046075467,-0.05026498,-0.09951977,-0.013222812,-0.0065982356,0.0005185385,0.042913698,-0.0032864662,0.032478265,0.03153687,0.067770466,0.0032912313,-0.030983461,-0.0039257524,-0.014472926,0.035391442,-0.0035127436,0.009368781,-0.009637816,0.024984544,0.0012988521,-0.08677597,-0.04089787,0.057385698,-0.023240268,-0.014310564,-0.0016581137,0.018531265,-0.069274195,-0.08531526,0.02262717,-0.04637861,0.014849198,0.031107984,-0.08441402,-5.9679e-34,-0.06961594,-0.08031693,0.028641196,-0.019206014,0.007997932,-0.039948694,0.013374149,-0.032758463,-0.013633582,-0.05075054,-0.042907864,-0.0018828274,0.00637575,0.10593077,-0.010460175,-0.0075461403,-0.11678988,0.046673127,0.11282332,-0.0030033616,0.021685949,0.055212732,0.04557745,-0.05777245,0.08244653,0.031390827,-0.027668873,-0.025774915,0.07636669,-0.01386206,0.05074542,-0.02916272,-0.10010876,-0.017101215,0.060304176,-0.017205264,-0.05382689,0.0012490439,0.049941413,-0.039134156,-0.069658056,-0.032120597,-0.053369563,0.043446288,0.042938333,-0.040235654,-0.040560078,0.055897526,-0.0132183675,0.031656686,0.050421756,-0.14288023,0.029782645,-0.042451203,0.0029798453,-0.0052511054,-0.037874416,0.050261464,-0.06392012,0.05912358,0.08525421,0.10951437,-0.013167027,0.005841766,0.06755693,0.04523778,-0.05576044,-0.114411674,0.033685803,0.0954491,-0.043170325,0.011444013,0.035399195,0.047595598,0.01953891,-0.0053276634,-0.10148605,-0.07391222,0.015784757,0.0261304,-0.025665227,-0.09892287,0.049531408,-0.015359771,-0.10122144,-0.022530474,-0.04354213,-0.017455095,-0.0027797802,-0.028449915,0.1280077,0.048003204,-0.08409611,0.10404873,0.005395697,-2.0778646e-33,0.11681052,-0.05435209,0.117096156,-0.03867162,-0.044254344,-0.026338935,0.02550412,-0.01234906,-0.011920638,0.016765391,0.021330673,0.08983005,0.020665977,-0.034356512,0.035942413,-0.040545616,-0.033702347,0.010360244,-0.038196992,-0.041286204,-0.0022735666,0.043189898,-0.017549824,0.014739631,-0.08019184,-0.019054724,-0.023121016,0.062480774,-0.018508054,0.00695723,-0.012047873,0.01198818,0.006812897,-0.067133136,-0.06551681,0.030819299,-0.009822889,0.011913951,-0.014421424,-0.0081937,0.0284152,0.08003818,-0.0014873579,0.04304779,0.016899105,0.07977904,-0.016885849,0.05696876,0.010987771,-0.005572343,0.0030278112,-0.015632998,-0.027992994,-0.0071089673,0.036402825,0.10303965,-0.033748195,-0.028051967,0.07241571,-0.060418457,-0.070560046,-0.05458593,0.10244312,-0.02395091,-0.0046284134,-0.017339699,0.0074293357,-0.058241732,-0.036839142,0.07427553,0.075697936,0.009194728,-0.027357906,0.003661606,0.030882189,0.014381935,-0.04379322,-0.0327293,-0.074251585,0.015739484,-0.026971638,0.033048373,-0.020542193,-0.0011181617,0.10278134,0.014831153,0.010403628,0.03305128,0.0037055188,0.051162783,0.015632179,0.0033096361,0.003271131,0.042168062,-0.009112426,-3.615721e-08,-0.0076740165,-0.05935287,-0.0069693928,-0.05585827,-0.012696895,0.03974218,-0.058607608,0.037196394,0.08408097,0.07287831,0.004224525,0.116915785,-0.020027619,0.05281423,0.064762406,0.06569413,-0.03588364,0.019262603,-0.024107091,-0.06707955,-0.043575544,-0.032711267,-0.042205215,0.05999418,0.07094195,-0.051924843,0.008767685,0.060214564,-0.015670458,-0.060084503,0.055601273,0.062253654,-0.00057722203,0.0010318286,-0.03868007,0.03517776,-0.07706476,-0.042467296,-0.06412346,0.060229465,0.051233333,-0.025199672,-0.08895733,-0.01815126,0.057101183,0.068422884,-0.05909966,0.070056744,-0.08781765,0.015447257,0.013674852,0.0060701994,-0.02260835,0.0025632442,-0.040109,-0.020637391,-0.075010866,-0.03389151,-0.026038114,0.01882776,0.025568474,0.014917807,0.14260472,-0.046922106 +7.5.2.2,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of lactose, melibiose and raffinose.",384,1.0,-0.06542886,-0.07772424,-0.025728455,-0.014987451,-0.07422935,0.036901146,0.04338684,0.07750868,0.059531663,-0.079742976,0.015698992,-0.083075844,-0.021787874,0.10078486,-0.011142034,-0.04830061,-0.06697246,0.036763214,0.02280044,-0.026275072,0.010900076,0.08867566,-0.027104968,0.03432968,-0.070324436,0.022709642,0.01730716,-0.039956693,-0.03319203,-0.045635577,-0.07851347,-0.023120048,0.042871118,0.021096721,-0.004946726,0.086276,0.01813472,-0.017718585,0.088624224,0.010498796,0.11235422,-0.010341637,0.098755896,0.0590159,-0.12974736,-0.020618154,0.059034266,0.03509882,0.0055110566,-0.01466271,-0.037061997,-0.04096066,-0.044218924,0.05019867,0.036256503,0.06634631,0.008882196,-0.025646126,-0.0057669706,-0.0663857,0.022712138,0.015246883,0.0969208,0.08699632,0.014344217,-0.06595559,-0.042061582,0.0297727,0.00196822,-0.028492725,-0.09457397,-0.08360661,-0.045099888,0.060106106,0.04470537,-0.0049703023,-0.006291189,0.0021344314,-0.012598832,-0.022396414,-0.010690896,-0.037870154,-0.021186596,0.04571607,0.018407503,-0.0371576,0.0506066,-0.0014902253,0.029290138,0.001530214,-0.039909348,-0.06595401,0.03145756,-0.044961464,-0.13285354,-0.026082532,-0.008324013,0.022430347,0.034521725,-0.008018615,0.058703598,0.037869666,0.06506592,-0.010607862,-0.020332787,-0.025765719,-0.029466927,0.028453058,-0.006554235,-0.0068547926,-0.02315197,0.036353733,0.009633344,-0.061491285,-0.037982885,0.06648995,-0.014388067,-0.01708484,-0.01737379,0.026043555,-0.07078265,-0.09427192,0.01591511,-0.03171664,0.021136986,0.011747431,-0.06582251,-7.846344e-34,-0.075270414,-0.06401275,0.0410874,-0.007856881,0.02926421,-0.04167736,-0.011381115,-0.05105933,-0.011340692,-0.070037566,-0.016960576,0.02810106,0.013555638,0.11099626,-0.006315341,0.0026090664,-0.10735804,0.047750287,0.07995852,-0.02106423,0.008417968,0.06562776,0.033420406,-0.06333629,0.096787624,0.012644137,-0.018244296,-0.019263659,0.07745849,-0.014048522,0.028633138,-0.042567354,-0.11005078,0.003645993,0.049475934,-0.03299066,-0.043338142,-0.019624798,0.01338547,-0.03048555,-0.106776066,-0.027988184,-0.06329448,0.06873761,0.04146069,-0.0653252,-0.029234393,0.051869784,-0.00850087,0.018039934,0.063849434,-0.15352897,0.06286297,-0.07087048,0.007742579,-0.016110934,-0.04639143,0.052657466,-0.05008171,0.067913316,0.1008463,0.10304723,-0.033541974,0.024811061,0.06109099,0.051761907,-0.066864,-0.11036668,0.066253126,0.09673857,-0.013627031,0.019467834,0.0444867,0.063451655,0.03213136,0.009097244,-0.09131046,-0.08095006,-0.0072802515,0.027438743,-0.036512136,-0.10364289,0.04019946,0.0029315343,-0.09718034,-0.03806007,-0.037149034,-0.03320739,0.018812714,-0.036623444,0.113920376,0.05235901,-0.0858913,0.0965416,0.02963689,-1.4289901e-33,0.11018709,-0.04025815,0.08608933,-0.03948179,-0.052469693,-0.018140558,0.016586924,0.0014120435,0.009280726,-0.020649593,0.00980399,0.056038354,0.028685238,-0.025631355,0.019923382,-0.062055837,-0.011020325,0.0021779875,-0.042399853,-0.03613085,0.020608397,0.016365424,-0.016729165,0.025566924,-0.08326925,0.0055659357,-0.05091917,0.07220878,-0.026253307,0.003545981,-0.014585622,0.029198937,0.012551815,-0.08818481,-0.059496738,0.027222974,0.017408902,0.032840688,-0.011622155,-0.0061993,0.010210005,0.07406815,0.006978588,0.034400627,0.007817293,0.08116501,-0.015232979,0.04057057,0.029958691,-0.017776608,0.0036014945,-0.03343715,-0.011790988,-0.01743816,0.04732233,0.10482266,-0.044898394,-0.021590795,0.101361655,-0.054328706,-0.058843773,-0.05827163,0.09097798,-0.026907887,-0.0050246357,-0.03057271,0.004023198,-0.07350315,-0.02560895,0.06792642,0.10712357,0.04408942,-0.017218571,0.034755707,0.026592962,0.036297675,-0.024407463,-0.061587766,-0.06740243,0.01857093,-0.030064728,0.021119583,-0.014015412,0.008572616,0.08716176,0.018355293,0.0047552795,0.0031588161,0.00088248734,0.01885794,0.019705122,0.003116151,-0.0116732335,0.06472932,-0.029541982,-3.6467654e-08,0.017436849,-0.061852764,-0.014864648,-0.06402833,-0.017885473,0.05557383,-0.054940186,0.026985202,0.10165044,0.045307368,0.014337499,0.12282659,-0.00083973916,0.045451332,0.061427858,0.06568475,-0.020795941,-0.00821904,-0.02309969,-0.056156762,-0.03138619,-0.042630862,-0.036961686,0.05723838,0.0839615,-0.04882768,0.0051596966,0.0746498,-0.02020049,-0.06562748,0.050156273,0.046310358,0.0026053505,0.0051177964,-0.039173637,0.059618562,-0.07002962,-0.023874816,-0.07147011,0.0764693,0.050431706,-0.047615822,-0.0882922,-0.010655097,0.056705307,0.044362262,-0.067043856,0.061156902,-0.077341266,-0.016255746,0.02927574,-0.0039618313,-0.0063388636,0.008123546,-0.058250025,-0.018519586,-0.05583847,-0.03721751,-0.025981056,0.016488364,0.028967774,0.015946211,0.13734044,-0.046409458 +7.6.2.1,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. Different forms of the enzyme move phospholipids such as phosphatidylcholine, lyso-phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidyglycerol, sphingomyelin and glucosylceramide from one membrane face to the other ('flippase').",384,0.99999994,-0.051722836,-0.063408606,-0.012763171,-0.025886206,-0.02661983,-0.009011787,0.027959319,0.026176551,0.05165078,-0.007286511,0.027497044,0.019908637,-0.06998304,0.10470309,-0.012237907,-0.06635007,-0.0630966,0.014180263,0.106416605,-0.039154015,0.0747559,0.0060186656,-0.0075818864,0.03172983,-0.04800681,0.056587882,0.032484815,-0.021540063,-0.025357105,-0.00082588306,-0.12212282,-0.0059189606,-0.010538328,-0.024605071,0.0111559,0.12179057,-0.086445875,0.077007346,0.031612106,-0.034188103,0.16294315,-0.05853266,-0.0045870957,0.044646807,-0.055976983,-0.027710287,0.0060585123,0.03993116,-0.009798469,-0.03932621,-0.019722234,-0.07548617,-0.11104412,0.009060996,-0.05974177,0.032785,-0.045995414,0.02329595,-0.009289612,-0.018523008,-0.035933185,0.016982956,0.011566356,0.084975325,0.055409133,-0.0519391,0.040948376,0.012921908,0.029141132,-0.031337917,-0.041388404,-0.03607859,-0.03739061,0.0050076507,0.006661937,-0.004301743,-0.036776356,0.042188775,-0.0054361145,-0.08156557,0.0734375,-0.0411016,-0.04565741,0.018153368,0.0665983,0.0031875987,-0.03942415,0.0012112322,0.035168152,-0.031599868,-0.009116712,-0.05678306,-0.01884469,0.0011860486,-0.09205207,0.004259788,-0.013689575,0.01991885,0.03594448,0.005812056,0.052932967,0.06003487,0.033524655,0.006733606,0.009359527,0.017489104,-0.052023675,-0.06869337,-0.0009026499,0.060697958,-0.071791954,0.014292249,0.06423619,-0.059873905,0.03707488,0.03195586,-0.061674286,0.03310167,0.0058921776,0.030387295,-0.056853037,-0.085777044,0.0062417407,0.0023137138,-0.025230056,0.052100796,-0.048805334,8.224661e-33,-0.0018513958,-0.009687464,0.05805895,-0.029674454,-0.026456892,-0.006147006,-0.026687443,-0.039672837,-0.07522803,-0.03598254,-0.019121407,-0.03032766,0.0124763,0.059787087,-0.0123452535,-0.03196012,-0.06506036,0.071644746,0.11112726,-0.044912286,-0.0019219043,0.071413115,-0.009512469,0.045109645,0.057386983,0.016546926,-0.05835482,-0.014929259,0.022476556,-0.008203903,0.037217986,-0.058433764,-0.0932923,-0.020638894,-0.021903543,-0.026231332,-0.095127426,-0.06468983,0.05472237,-0.08173075,-0.15884483,-0.07282272,-0.036903173,-0.021253899,0.007828256,-0.0275216,-0.074812844,0.068174124,-0.0025750417,0.052013606,0.03653234,-0.08998869,0.082415886,-0.016367612,-0.04445404,0.006733766,0.034859747,0.009923264,-0.017866181,0.02704397,0.12413856,0.099950805,-0.0609701,-0.042890266,0.012668507,0.059338897,-0.10052842,-0.0913001,-0.0027959547,0.090912886,-0.056708936,0.034756687,-0.023049725,0.033416774,0.047742344,0.007990595,0.026468446,-0.018587574,-0.061998315,0.050328087,-0.0037002545,-0.035156578,0.06271225,0.013217001,-0.032917894,-0.026213946,-0.002057602,-0.062169306,0.024608117,-0.028513467,0.038243596,-0.00075109006,-0.023851195,0.116671346,0.026543679,-9.011537e-33,0.03943613,-0.05098026,0.058544476,-0.09681971,-0.058016025,0.0028680295,0.03571867,0.030553296,0.050458282,0.0112889595,-0.034786884,-0.011488244,-0.017385298,-0.04288042,-0.00060119457,-0.025505781,-0.00821795,0.03651314,0.07973142,0.017478831,-0.002912469,0.13043554,-0.011084723,0.077986754,-0.0062959106,-0.017456533,0.002631585,0.08012575,0.005621301,0.021709975,-0.020791577,0.0037410522,-0.013182214,-0.012604476,-0.07953782,-0.0036020107,0.009313858,0.029644767,-0.011964558,0.051263317,0.046019316,0.05510305,0.13656588,0.008627312,0.04724908,0.060556255,-0.04389891,0.04020502,-0.07361862,-0.0322835,-0.02984771,0.09075336,-0.07477339,0.043443393,0.07315184,0.07464805,0.019187612,0.0119117135,-0.02768594,-0.10572487,-0.06158669,-0.138753,-0.004501395,0.050051898,0.029274441,-0.01366946,-0.02482994,-0.07863139,-0.026399845,0.047923967,0.050236985,0.08367443,-0.06304722,-0.0017456107,0.037282605,0.003815163,-0.00016748266,-0.023515986,-0.025877148,-0.0046173926,-0.003249298,0.02970454,0.0154136205,-0.018545577,-0.01778427,-0.029499779,-0.01990537,0.014579279,0.0450602,0.014100809,0.03220204,-0.023965934,0.014433611,0.0023773457,0.018597484,-4.3019675e-08,0.03655474,-0.025423346,0.09155423,-0.06345893,0.027803743,-0.0047782813,0.041258648,-0.014796737,0.0786375,0.0076376423,-0.04014732,0.045530926,0.050583176,-0.010508097,0.08372436,0.10350647,-0.07316958,0.06791358,-0.020698782,-0.075946525,0.020624394,-0.03338833,-0.118733585,0.12083047,0.07126481,-0.03859827,0.04426952,0.026852978,-0.07459998,-0.038247425,0.018674435,0.014703854,0.030922,-0.028107958,-0.03323052,0.048963815,-0.0524246,-0.0013951511,-0.067178994,0.08056893,-0.0447847,-0.04022149,-0.027702725,0.011354874,0.050036214,0.053039916,0.0516887,0.0062307096,0.017027926,-0.029590841,0.040759075,0.010157314,-0.04543332,-0.12254753,-0.08558273,0.0050154775,-0.026027558,-0.046321727,-0.00025063904,-0.05238729,0.056585345,0.0067374646,0.18434933,-0.018012082 +7.6.2.2,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them also transport glutathione---drug conjugates (see EC 7.6.2.3, ABC-type glutathione-S-conjugate transporter) while others also show some 'flippase' activity (cf. EC 7.6.2.1, P-type phospholipid transporter).",384,1.0,-0.04136119,-0.089721195,-0.053979263,-0.04269464,-0.039277412,-0.00984769,0.026444308,0.10268319,0.055384867,-0.036357097,0.02224546,-0.0022645746,0.00095869973,0.08995414,-0.020715576,-0.027214227,-0.06773035,0.011635365,-0.0183744,0.0017893579,0.03176291,0.040866416,-0.07793261,0.025211215,-0.043102935,0.06503354,0.0075741317,-0.08338478,-0.04492495,-0.02913792,-0.09743043,-0.032650832,-0.037123952,0.04172994,0.019505018,0.102728836,-0.09222193,0.022184983,0.12359732,-0.008008545,0.12163085,-0.014857131,0.07216109,0.017476946,-0.055423047,-0.027374586,-0.01106001,0.020308124,0.035913177,0.011719969,-0.023714298,-0.0093414625,-0.052274916,0.09113067,-0.019614,0.026336525,-0.024080973,-0.0029821703,-0.009955505,0.068153046,-0.04923002,-0.024728255,0.08425617,0.02534252,0.0072138724,-0.057160724,-0.05577315,0.021094402,-0.00803652,-0.015148509,-0.044944715,-0.04528394,-0.016160307,0.04243478,0.011740199,0.019875553,-0.021929251,0.071750745,-0.06627678,-0.07490683,0.08271427,-0.070540085,-0.0103963725,0.054287665,0.06292394,-0.041137848,-0.026810145,0.033320855,0.03560345,0.029035173,0.0073587038,-0.02115299,0.041765902,-0.05580715,-0.10922119,-0.020299558,-0.0054730293,0.07467097,-0.0038874852,-0.021042064,0.05523471,0.03255994,0.06538467,-0.009202082,-0.027373131,-0.017128175,0.056366075,0.015177653,-0.061281234,-0.016472852,-0.0049855537,0.041045282,0.06463405,-0.05930159,-0.038585257,0.0442435,-0.005974239,0.0069521437,-0.048031487,0.009293895,-0.06192011,-0.09303125,0.11901076,-0.05371887,-0.00047950612,0.02265042,-0.043673474,1.8204786e-33,-0.065641955,-0.019160071,0.030177826,0.002340835,0.010977614,-0.013320725,-0.02927573,-0.06876918,0.002500858,-0.06380241,-0.061107587,0.0106871715,-0.038774583,0.07096485,-0.035169784,0.06334737,-0.039626863,0.0035058248,0.07505611,-0.06192775,0.06074137,0.008162837,-0.045337226,-0.031969916,0.025345003,-0.0018732382,-0.08881416,-0.007911176,0.011897623,-0.024171172,0.005194004,-0.03312163,-0.05792431,-0.00069980987,0.037125412,0.003176662,-0.052133046,-0.04756939,0.01116657,-0.051210057,-0.07901981,-0.008678287,-0.06252855,0.030288717,0.07372241,-0.0044783438,-0.08673526,0.02583762,-0.04233967,0.044310495,9.922677e-05,-0.14506696,0.075973295,-0.070352376,-0.0352166,-0.03674841,-0.020865047,0.0006293131,0.01017355,0.10539268,0.062022023,0.14100836,-0.11645632,-0.042250026,0.0147178825,0.05417159,-0.07719276,-0.101047605,-0.02114185,0.111520484,-0.0251376,0.00032551118,-0.0056035067,0.06297621,0.097960874,0.0017882831,-0.030991316,-0.017645186,-0.029561859,0.045861352,-0.009982366,-0.07703044,0.029021643,0.031324714,-0.10354596,-0.017101906,0.00928145,-0.08835928,-0.003549689,-0.023725754,0.094016045,0.0020889582,-0.06567805,0.092134684,0.015690686,-3.5878196e-33,0.075743124,-0.03599479,0.09788626,-0.078692265,-0.051465128,0.09595998,0.009654284,-0.035226002,0.080750145,-0.007119856,0.022743238,0.016573919,-0.0221959,-0.057839897,-0.007914112,-0.050454997,-0.0011475802,0.07498952,-0.012070097,-0.019935366,-0.029698873,0.08753623,0.021990033,0.11788265,-0.036205664,0.0039784727,-0.022400672,0.072514586,0.0023670008,0.07162137,-0.022848602,0.07362074,0.0021682675,-0.027893867,-0.0872537,-0.013668474,-0.04416512,0.015250016,0.0257904,-0.0071367044,0.067181736,0.052412167,0.057860125,0.02895758,-0.0327529,0.049106978,-0.076289885,0.088441074,-0.01793512,-0.06857682,0.013383971,0.010768883,-0.02581819,-0.009816569,0.11054798,0.09118067,-0.0229782,-0.035279214,0.003230384,-0.08604526,-0.05860476,-0.0842203,0.008643881,-0.078745,-0.005828963,0.0019740015,0.04156496,0.021972552,-0.020780258,0.060668893,0.026256153,0.008452953,-0.0067198807,0.012500135,-0.0066933115,0.017010827,-0.034910955,-0.060129583,-0.010437136,0.008633793,0.033377763,0.015072193,-0.0126564605,-0.033230796,0.05960452,0.007894509,0.005218427,0.049804907,0.06805299,0.052380215,0.022579797,0.015027534,0.004156881,0.05489075,-0.007545246,-4.6657757e-08,0.06173381,-0.026500437,0.058451075,-0.045789666,-0.047518607,0.052936334,-0.039478667,0.016381739,0.06763161,0.04436488,-0.027803611,0.11129416,-0.04183501,-0.021410247,0.017900614,0.09682002,-0.06302482,0.025070686,0.012036717,-0.027984146,-0.03509794,-0.071800224,-0.011967778,0.061201483,0.07652265,-0.054585934,0.021968551,0.0048103146,0.009916968,-0.049890175,0.035180513,-0.033975556,0.01320029,0.0076640174,-0.06849152,0.008441395,-0.02596647,-0.04135258,-0.05912114,0.080313794,0.04038149,-0.024158837,-0.07180679,0.041217063,0.010055363,0.063001394,0.0028834953,0.04196657,-0.027662255,-0.043299697,0.031524207,-0.02363244,0.022736367,-0.046419278,-0.09599475,0.009994481,-0.0769633,-0.023870215,-0.0009983698,-0.061587397,0.04818449,0.037482664,0.17421176,0.051971983 +7.6.2.3,"A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.",384,1.0,-0.047103696,-0.0045408006,-0.08017274,-0.011394004,-0.005815001,0.017726626,0.03517481,0.08865215,0.022446519,-0.0155994175,0.049650446,-0.013956872,0.004776095,0.031252503,-0.065889776,-0.048916027,-0.008184,0.049828794,-0.029887205,-0.043632817,-0.012664883,0.05702961,-0.024378186,0.029549671,-0.0074844784,0.013484641,-0.06707517,-0.069661684,-0.016581524,-0.043352515,-0.10918279,-0.071359344,-0.05697198,0.06914217,-0.034389768,0.082771055,-0.0820855,0.044163134,0.0709904,-0.0075107794,0.08265844,-0.021671053,0.05744481,0.08807973,-0.073953085,-0.043503802,-0.0071766903,-0.016156279,0.03469396,0.058727495,0.0058490504,-0.0066588554,-0.06330794,0.10510262,0.002413077,0.031368826,-0.022445042,0.0023440416,-0.0147305485,0.03333501,0.009579512,-0.017303556,0.032655362,0.019214313,-0.02122657,-0.110268965,-0.040755585,0.064801864,-0.034173552,0.019596253,-0.018158361,-0.018753111,-0.06479732,0.023667816,0.0123432465,-0.00710197,-0.07109099,0.012962449,0.009611735,-0.01873779,0.0722207,-0.01653098,0.022388633,0.09329598,0.044604298,0.02276025,-0.0029788932,0.029604975,0.006899418,-0.012777105,0.0005331133,-0.042725228,0.008651051,0.0036002337,-0.16655196,0.01857066,0.0041134474,0.05061687,-0.014926093,-0.017826542,0.054239117,0.014272928,0.0534414,-0.036062464,-0.07294206,-0.04001439,0.0007552665,-0.005595858,-0.044963837,0.031810362,0.0036657432,0.04366197,-0.0011957644,-0.020707414,-0.041153014,0.102389105,0.033619262,-0.007692941,-0.03729836,-0.041615803,-0.044255603,-0.02270834,0.05353981,0.004331097,0.023199124,0.013543721,0.021703808,4.539279e-34,-0.057278663,-0.032578126,0.03951312,0.0018908577,0.0008265257,-0.008816152,-0.034818046,-0.075495,0.008383769,-0.06937611,-0.12693356,0.0033077407,-0.07261008,0.08984595,-0.037774507,-0.0047446038,-0.055001814,-0.025190018,0.09821187,-0.059186522,0.050109956,-0.022136975,-0.034163702,-0.035950076,0.015449289,0.01219617,-0.08909729,0.029948084,0.019774143,-0.008202559,-0.0074877306,-0.026402924,-0.025517333,0.0035841153,0.03104053,-0.019035915,-0.044565424,-0.07094884,0.026110332,-0.029510826,-0.062199075,-0.004063836,-0.013612008,-0.009802086,0.090574995,-0.023846895,-0.07696252,0.008396397,-0.039669428,0.050583232,0.0047183703,-0.14180343,0.061046313,0.009052999,-0.05821856,-0.04382144,0.00048187425,-0.05064984,-0.0340662,0.11945649,0.038041133,0.11479319,-0.05149479,-0.0038348245,0.013938003,0.004618502,-0.12778826,-0.039762016,-0.0016597753,0.10863705,-0.034442432,-0.023548998,-0.037260786,0.042576924,0.06927302,0.020388683,-0.063379206,0.030612106,-0.04693031,0.058898784,-0.03794603,-0.046592228,-0.03242156,0.012128101,-0.069586396,-0.0011962022,0.0012876508,-0.119679354,0.051618278,-0.0392547,0.06839515,0.021890093,-0.032844547,0.08362714,0.015396249,-2.0494966e-33,0.09390563,-0.06062403,0.14451247,-0.027542934,-0.033123568,0.052259546,0.00074801117,-0.078704506,0.072236635,0.015016794,-0.033102732,0.049080074,-0.0053564855,-0.036848202,0.034370627,-0.10765189,0.009005611,0.08376731,-0.034476895,-0.08369912,-0.046763778,0.10202728,0.008083749,0.08433351,-0.041471988,-0.046331782,-0.0022620042,0.03985059,0.041218277,0.06832465,0.0063182185,0.031808123,-0.012300797,-0.0034136074,-0.039376482,0.013213962,0.010806697,0.08307993,0.025001185,-0.011364715,0.0583451,0.042213067,0.009690881,0.07906605,0.016629074,0.06889538,-0.074912295,0.05640061,-0.0061422447,-0.041340183,0.07045095,0.011720748,-0.023884296,-0.022915015,0.13892742,0.065230794,-0.018453458,-0.06873965,0.012351639,-0.06864718,-0.06912153,-0.04845541,-0.0333506,-0.12277833,-0.00800221,0.027270583,0.065844595,0.057535075,0.015561729,0.086129904,0.06734128,0.018392393,-0.018455882,0.0262702,-0.030276576,0.009415926,-0.026949942,-0.017259171,-0.021259475,-0.0048396266,0.010244978,0.025216585,-0.010184809,-0.066416584,0.079891324,-0.038474675,-0.01897568,0.07484159,0.0086168675,0.053866625,-0.014149416,0.0018630398,0.016907034,0.031392306,-0.030938897,-3.7177482e-08,0.0019217918,-0.025174366,0.04809764,-0.057389993,-0.05544582,0.07777767,-0.0037274824,0.040525902,0.10913444,0.054905333,-0.016970284,0.1286176,0.040381167,0.006161994,0.017599024,0.13707167,0.036500514,0.02581757,0.0037027535,-0.011508228,-0.094774835,-0.04726638,-0.05410476,0.054106433,-0.00935,-0.07869295,-0.00035118774,0.035757422,0.030141626,-0.02026889,0.06601846,-0.009826879,-0.00030727396,0.014328768,-0.056567833,0.028829573,-0.013503476,-0.03766602,0.010859219,0.06787031,0.029112462,0.006154941,-0.040757857,0.02815002,-0.020859001,0.022185016,-0.046555538,0.03397987,-0.08748298,0.022689572,0.041040722,-0.016599078,0.028044397,-0.03259965,-0.09208556,-0.05670702,-0.07261145,-0.011880409,-0.017999092,-0.031484224,-0.0096310275,0.016226532,0.18227518,0.07591211 +1.1.1.415,"The enzyme, characterized from the plant Papaver somniferum (opium poppy), catalyses the last step in the biosynthesis of the isoquinoline alkaloid noscapine.",384,1.0,0.022903673,0.0070803324,-0.07962518,0.0028833817,0.028861813,0.066852935,-0.07748696,0.043439444,0.065587945,-0.08180978,0.037901297,-0.0031922823,-0.036335323,-0.04097162,-0.049942657,0.025915354,-0.09783653,0.04218453,0.01811332,-0.037615057,0.028299564,0.027189348,0.051472604,0.025718523,0.035753794,0.082393676,-0.057138916,-0.015997838,0.051052812,-0.07630136,0.08076135,0.0005080755,0.01869783,-0.053141147,-0.049867645,0.03616048,-0.06563939,-0.008572165,0.11024433,0.05942428,0.06285889,-0.069045454,-0.06689584,0.02662299,-0.0181448,0.014361041,0.0028506056,0.03907607,0.039515253,-0.02425492,-0.033596758,-0.07218097,-0.08493036,0.06936676,-0.009154972,-0.022609893,0.020174405,0.017380092,-0.027688056,0.05519387,0.004691249,0.055857427,0.0047493624,0.036512934,0.06852363,-0.016042149,0.0060329223,-0.016059455,0.09461684,-0.0055143847,-0.015971404,-0.088646375,-0.0146691045,0.006599054,-0.07332506,0.07170039,-0.078435235,0.0317088,-0.01890147,-0.0067457757,0.08691053,0.030010521,-0.018957566,0.10430312,-0.012151422,-0.016667893,-0.042610686,0.02715903,0.07056362,0.006660194,0.04439935,0.012348289,-0.106530376,0.013788965,-0.044564407,0.0022913145,0.08204448,0.05044239,-0.03390933,-0.01614541,0.026065536,0.05071641,-0.116047144,-0.10773252,-0.0069434196,0.0076476648,-0.0458186,-0.057766274,0.0011784838,0.011468968,-0.028173251,-0.072834104,-0.036703642,0.022343535,-0.03068009,0.058354322,0.062559314,-0.050632108,-0.07699996,-0.026057053,-0.09087435,0.026959453,0.040540922,0.027177453,-0.026189009,0.037711438,-0.050702445,8.538436e-34,0.013699593,0.06102614,-0.02370746,-0.05602635,-0.008890964,-0.06638649,0.0080463635,0.06102699,-0.032757565,-0.025344254,-0.07540521,-0.0631734,-0.054337915,0.024367379,0.043769486,-0.043311078,-0.023145746,-0.048825465,0.058114067,-0.07205703,-0.05521564,0.014400653,-0.07516564,0.022911638,0.020405639,0.123070486,-0.03254414,-0.005165105,0.0051992545,-0.022811253,0.016627511,-0.02359429,-0.06314818,-0.033715468,0.03362208,-0.015686782,-0.041272126,-0.03621995,-0.053180672,0.038071714,-0.006322931,0.03976122,0.07933543,-0.008093409,-0.0072053145,-0.0010584929,-0.09016364,0.110816754,0.11206474,0.031108767,0.02539543,-0.010433597,0.013233714,0.029112708,-0.05665813,0.03706187,-0.04593229,-0.004242831,-0.033302903,0.021821491,-0.004068348,-0.025625333,0.020734873,0.06717037,0.045914665,0.012243402,-0.07642293,0.018770069,0.03328732,0.076943874,-0.04109663,-0.004519096,-0.029849164,0.05482316,0.016110618,0.029041214,-0.00027294594,-0.01479689,0.03585779,-0.050684076,0.008530685,-0.029715167,-0.016193008,-0.00023053882,-0.026855156,0.017077683,0.04882622,0.013248447,-0.039363213,0.10016832,-0.02781237,0.0021446517,-0.06640941,-0.012560608,-0.006581157,-1.698646e-33,0.09774892,-0.09131332,-0.009335606,-0.035965938,-0.023073591,0.074227534,-0.090973265,0.047341283,0.014322076,0.109368674,0.0010330045,-0.02203758,0.11360274,0.0095565,-0.033113014,-0.041254126,0.02890004,0.09818498,0.009966828,0.012240453,-0.04536548,0.07427913,-0.0688065,0.058020648,0.006369875,0.010200377,0.071301,0.0046437476,0.010636209,0.07531037,0.07128466,-0.020055048,-0.045605488,0.014254616,-0.026875166,0.13918386,0.060749426,0.02769078,0.014037382,0.012302396,9.3578645e-05,-0.021794772,0.011423428,0.017186997,0.08242832,-0.023787215,-0.08365954,0.06537822,-0.00887786,-0.029782306,0.0934974,0.034939755,0.0061450475,0.027822305,-0.0076583237,0.014317347,-0.034422822,-0.12797531,-0.008561799,-0.12337163,0.018731367,-0.025063641,-0.05095865,-0.07856732,-0.0015622436,-0.0011919622,-0.058612663,0.030873198,-0.007436814,-0.0058969203,0.07931097,-0.026670163,0.0010600468,0.08159442,-0.036745567,-0.026054595,-0.030628895,-0.03886155,0.027583158,-0.07537446,-0.0018634201,-0.015193056,0.054164987,-0.037642453,-0.0134675745,0.0134592485,0.03477142,0.113364235,-0.001662186,0.029763808,0.011707901,-0.0026865504,-0.13141713,0.048692923,0.03525852,-2.7008326e-08,0.015474759,-0.05226957,0.07247629,0.037958365,-0.026437875,0.06789769,0.024778277,-0.044351585,-0.008159869,-0.048066955,0.029725399,0.07460662,-0.041374784,0.06359152,-0.005542437,-0.0054556658,0.015027923,0.05476021,-0.030518465,-0.021035386,-0.10327412,0.026862435,-0.023707787,-0.089517534,0.045645688,-0.04322894,0.05808579,0.08419216,0.016635342,0.017624533,0.065655515,-0.0049574645,-0.033656098,-0.05684932,-0.066115774,0.07394605,0.045127336,-0.087595485,0.06615052,-0.0330993,-0.025669543,-0.04303379,-0.08229305,0.01369915,-0.038664967,-0.022908708,0.04753698,-0.014956097,0.002839524,-0.00061730505,0.013468752,-0.02977539,0.054366793,-0.059289496,-0.07672908,-0.015499822,-0.02521962,-0.0064523662,-0.024418551,-0.12873827,0.028134001,-0.014718829,0.22192344,0.026889998 +1.2.1.101,"The enzyme, characterized from the ascomycete fungus Aspergillus flavus, is specific for L-tyrosine. It contains three domains - an adenylation domain, a peptidyl-carrier protein (PCP) domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the PCP domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to the aldehyde.",384,1.0,-0.018165931,-0.056730345,-0.13111632,-0.05536446,0.10901218,0.010136945,-0.027396588,0.0615292,0.066854365,-0.010165165,0.044676404,-0.03283784,-0.08135539,0.025386179,-0.073230974,0.042417374,-0.032846782,-0.034243904,0.0025218758,-0.080964245,0.08041771,0.04678906,0.035895623,0.016317716,0.047545657,-0.05445424,0.043363117,0.008209782,-0.071216166,-0.09297775,-0.056196246,0.025657877,0.034370657,-0.07488273,0.0090554245,0.112167835,-0.0653206,-0.08562211,0.022199256,0.015150727,0.023015276,-0.08332611,-0.03174783,0.029168842,-0.07100776,0.024132121,-4.661107e-05,0.096301205,0.04016563,0.02766883,-0.010889861,-0.04732861,-0.008149472,0.011395382,-0.12884961,0.07476176,-0.030853957,0.04988366,-0.025790364,0.035563458,-0.0040231124,0.03734134,-0.01414159,0.040234726,0.016321309,-0.025111506,0.020257335,-0.03807282,-0.040746573,-0.018029097,-0.041242506,-0.062953606,-0.00987582,0.023030529,0.076945454,0.031740703,0.010964894,-0.0040564984,0.031971686,-0.047824826,0.06014331,0.04660196,0.04221951,0.067385726,0.007426131,-0.048590902,-0.030771397,0.015785674,0.04539779,0.016636243,0.0755166,-0.02034138,-0.01570442,-0.0061990162,-0.0733829,0.026568804,0.053779747,0.03427477,0.0094652185,-0.025905741,0.00360987,0.022808209,0.012389738,-0.032066077,-0.05897446,-0.015827918,-0.01458326,0.0963094,0.013670424,-0.09594905,0.035545092,0.020399956,0.089072116,-0.05280265,0.013391878,-0.007204388,-0.0077735046,-0.07490626,-0.019300414,-0.05212122,0.0038485883,-0.00023580383,0.03418466,0.050291367,0.013502969,0.014073305,-0.07838496,2.2067805e-33,0.10967658,0.09883163,-0.03840005,-0.008343805,0.043497093,-0.009043895,-0.026005104,-0.020997005,-0.07252026,0.01932508,-0.08989235,-0.06562396,-0.045135602,-0.00058186403,-0.015450997,0.027821736,-0.027828615,0.033651963,0.03415949,0.09543934,-0.005659682,0.121028975,-0.07677418,0.021912847,0.007922579,0.08795994,-0.043541573,0.020821681,-0.007335499,-0.008237492,-0.014548173,-0.051495053,-0.10105728,0.03235278,0.02702038,0.0015446589,-0.005725006,-0.04523845,0.01758868,-0.021826647,0.014858695,0.055693056,0.0051210904,-0.0078109303,0.012982339,-0.049217198,-0.02388226,0.07281393,0.0050702575,0.028421467,0.100686565,-0.05895186,0.12794638,-0.021031797,-0.024187103,0.05314955,-0.12516788,0.021702416,0.012269238,0.06856404,0.08203971,0.013756305,-0.012711445,0.08026116,-0.03838053,-0.034803383,-0.045929775,-0.108860016,0.029949032,0.07693889,-0.042760894,-0.012331092,0.0786798,0.04521178,0.025255907,-0.008362407,-0.063121974,-0.024457904,-0.010929957,-0.01168792,-0.021832196,-0.045077037,-0.0083196135,-0.040944453,-0.03853527,-0.011241849,0.02606641,-0.09016616,-0.025635965,0.0046089375,-0.02537736,-0.075394616,-0.007845695,0.041237667,0.06806756,-3.4357386e-33,0.12281403,-0.11348628,0.043857526,-0.04939099,-0.08228247,0.07597591,0.041072376,-0.047333136,0.0021245512,-0.015108833,0.105357885,-0.0077715237,-0.04238833,-0.08195203,0.021601297,-0.034242168,0.059023015,0.052144222,-0.086030155,-0.050324205,-0.07157575,0.021733768,0.024940014,0.051625337,0.056087386,-0.013204878,-0.06362615,0.053360734,0.0078958385,0.023582716,-0.014420916,0.019058304,-0.02607496,0.008864321,-0.0062257703,0.08627031,-0.0531915,0.00525226,0.04263911,0.048563167,0.06126442,-0.04089378,-0.012858766,0.0143281575,-0.033427946,0.07182492,-0.11262865,-0.0032454235,0.056945488,-0.078757465,0.016942902,-0.015672123,0.03144053,-0.015094136,0.020519923,0.07041362,0.029452851,-0.045374475,-0.018733807,-0.008948932,-0.027794678,-0.039643444,-0.0024115473,0.04476417,0.027431225,0.015044046,-0.053920936,0.032395545,0.07852881,0.035377048,0.047294926,0.029081222,0.041418213,0.09365119,-0.035776254,-0.0865661,-0.009749183,-0.04643324,0.012495936,-0.077838734,0.015575135,-0.053634286,0.046960235,-0.05162254,-0.025201743,-0.060712628,0.057835538,0.09056841,-0.03448141,0.044346303,0.054563183,-0.0031373114,-0.032434236,0.030387802,0.06847921,-4.736199e-08,0.06245177,-0.0038438004,0.005808357,-0.09132651,-0.054087523,0.03415614,0.025307551,-0.0048076827,0.022413736,-0.0029509699,-0.09158261,0.1013272,-0.019162742,0.0033141014,0.023666587,0.019581057,-0.021778196,0.053043332,-0.013075256,-0.035880655,-0.044280283,0.009415947,-0.13479319,-0.0065292115,0.041436907,-0.0119715305,0.031712133,0.051540315,0.12646833,0.053474274,0.022477763,0.0061073755,-0.017472949,-0.003321053,-0.009603397,0.02107637,-0.07313099,-0.05047608,-0.04684287,-0.0014758139,-0.028566005,0.0070963763,-0.084553756,-0.0126469815,-0.045187134,-0.012615651,0.028718207,0.050451994,0.002957544,0.054590203,0.03144693,0.026259927,-0.010047761,-0.02482413,-0.08360539,-0.00046060127,0.015690908,-0.01801828,-0.015295157,-0.12565924,-0.039970506,0.012286135,0.1836507,-0.0693912 +1.3.1.118,"InhA is a component of the fatty acid synthase (FAS) II system of Mycobacterium tuberculosis, catalysing an enoyl-[acyl-carrier-protein] reductase step. The enzyme acts on very long and unsaturated fatty acids that form the meromycolic component of mycolic acids. It extends FASI-derived C20 fatty acids to form C60 to C90 mycolic acids. The enzyme, which forms a homotetramer, is the target of the preferred antitubercular drug isoniazid.",384,1.0,-0.09977026,-0.0061934097,-0.14668237,-0.02127562,0.07968767,-0.0031884671,-0.02168356,0.115250036,0.015246958,-0.013338297,0.006491483,-0.08775246,0.052955106,0.00900367,-0.022893753,0.029013835,-0.015515798,-0.09894052,-0.021468103,-0.056578055,-0.031401414,0.11059025,-0.038623445,-0.007490286,-0.009818386,-0.08010714,0.008972727,-0.027513593,-0.04978473,-0.10569344,0.019755634,-0.015647974,0.058390677,-0.037110575,0.03249,0.048805397,-0.018100778,-0.04080615,0.107658274,-0.010937245,0.021744203,-0.07848802,0.03748803,0.0047262115,0.039618064,0.0014874825,-0.033552285,0.07118697,0.027376704,0.04761967,-0.09836179,-0.013760315,-0.03898938,0.075378105,0.007681677,-0.016209327,-0.07373503,0.035655834,-0.058723282,-0.0002873672,0.0478054,-0.016010374,0.005993571,0.055389524,-0.012675943,-0.02475158,-0.029438173,-0.0657483,0.01904786,0.0007255837,-0.0479564,-0.04806183,-0.051318556,0.09955273,0.06228496,0.019539142,-0.051607285,-0.0044509657,0.042867657,0.025824193,0.03310552,-0.02344948,0.0061197802,0.03381498,0.05752476,-0.008540903,0.067754105,-0.0063987067,-0.010853387,0.040438607,0.04333728,-0.05610778,-0.0032082873,-0.008860466,-0.075247355,0.014364733,0.030692609,0.03194297,-0.026681444,0.00227582,-0.012627362,-0.027154338,-0.0058067027,-0.029999167,-0.09734994,-0.05022412,-0.033316176,0.052232895,0.008714562,-0.030904151,0.0057560946,-0.06933367,0.08427315,-0.036764774,-0.0076699983,0.05096815,0.102096215,-0.08858654,0.0034596398,-0.044014286,-0.024338372,-0.029779574,0.036355082,0.008195305,-0.057516247,0.0012723383,-0.09937061,2.7315179e-33,-0.008538712,-0.030249698,0.033212554,-0.036920197,0.018161444,-0.04846669,-0.052772675,-0.038764622,-0.03861064,-0.047138795,-0.042117085,-0.014529343,-0.006221521,0.06356465,-0.02854797,-0.017212886,0.014284136,0.03121057,0.04133298,-0.038116556,0.006788687,0.098328814,-0.012643387,-0.05178115,0.024730409,0.081835926,-0.0098269135,-0.056784015,0.016216623,0.024198245,0.05185489,-0.007890838,-0.11256053,0.018148176,-0.013638523,-0.009861459,-0.01851243,-0.024753122,-0.02097197,0.04242372,0.06992119,0.043903336,-0.0060051493,-0.043144945,0.008217675,0.03358186,-0.04667054,0.071255304,0.0062982617,0.011115866,0.08446214,-0.015915152,0.028179698,0.035804152,0.0046475884,0.014219573,-0.032182988,0.007509683,0.067859225,0.044153683,-0.013331379,-0.014680298,-0.067194335,0.09420298,-0.120148115,-0.11463121,-0.07094565,-0.032167252,0.050177887,0.06413229,0.009484194,-0.013472284,0.09831502,0.020743473,0.0130908005,-0.019731116,-0.10845373,-0.028232714,-0.03471527,-2.056823e-05,0.024704838,0.008165409,-0.013516908,-0.010644134,-0.061825946,-0.021150041,-0.056159243,-0.052633513,-0.032278515,-0.02091745,-0.03487574,-0.044038624,-0.06345169,0.04273693,0.029918393,-4.3031292e-33,0.123234324,-0.12371674,0.09809602,-0.079780996,0.03947007,0.030940812,0.13422704,-0.011574297,0.08854708,0.019452991,0.05963449,0.010463284,0.010044275,-0.008920823,0.04846565,-0.038282853,0.01192823,0.007414819,-0.016691504,-0.021210639,-0.008310947,0.06641928,0.030550402,0.08329171,-0.04259403,0.08425958,-0.05614902,0.021543218,0.009271819,0.106860116,-0.049047887,0.033248994,-0.036246333,-0.044444017,-0.12811235,-0.0017022229,-0.056896985,-0.047744293,-0.051857892,-0.045415584,0.037722446,0.0706191,-0.03671573,0.015327983,0.039567355,0.007544183,-0.025337134,0.019105606,-0.006713696,-0.08364298,0.039405912,-0.0086052315,0.041566633,-0.0046218857,0.06302319,0.044340268,-0.020391148,-0.004869937,-0.022684732,-0.06576261,-0.06833533,-0.04904437,0.010451739,-0.06536398,0.051264483,0.0767767,0.016533406,0.0034320902,0.063761845,-0.045115434,0.048171625,-0.04923565,-0.04691244,0.07934778,0.07293427,-0.06529818,-0.073191024,0.012978955,0.043945532,0.0205733,-0.13894491,-0.022199571,0.00846072,0.0025266309,5.338476e-05,-0.08938611,-0.033696435,0.039654132,0.0071726637,0.082853995,-0.042538058,0.112902015,-0.052548032,0.0678973,0.06674054,-4.2534502e-08,0.025778279,-0.086612135,0.064241886,0.03408677,-0.06394307,-0.009509958,0.0029907264,0.03786069,0.08884619,-0.0362422,0.006736178,0.1075549,0.07471004,0.0107204635,0.034108177,0.045297988,0.014604455,-0.025572963,-0.03951083,-0.09222724,-0.084834054,0.033730514,0.0037678475,-0.006649386,-0.011710629,0.009213289,-0.039147142,0.04525111,0.017928159,0.080092646,-0.03960833,0.008054872,0.025837358,-0.003309532,-0.07045138,0.030156,0.06251554,-0.03561403,-0.010653099,0.026975887,0.03028034,0.00014256572,-0.033627633,0.009262896,-0.008614583,0.048287284,-0.02730253,0.09307124,-0.029451158,-0.047681678,-0.00978606,0.014804732,-0.029486151,0.023321074,-0.07744621,0.023973936,-0.05400407,-0.027687518,-0.011787947,-0.011813779,0.07872467,0.01596076,0.20194113,0.002456916 +1.3.1.119,"This bacterial enzyme can transform various dihydrodiols of chlorobenzenes into the respective catechols, including the dihydrodiols of mono-, di-, tri-, and tetra-chlorinated benzenes. It also accepts the dihydrodiols of various chlorotoluenes. Substrates for the enzyme are generated by the broad spectrum EC 1.14.12.26, chlorobenzene dioxygenase.",384,1.0,-0.07472776,-0.0047197607,-0.08865101,-0.03139842,0.09060812,0.022151547,-0.032681774,0.023949582,0.00896273,-0.05475941,-0.026701972,-0.12321892,-0.018091135,0.028020905,-0.05481275,0.037822478,-0.13167743,0.03589602,0.014181411,0.011108547,-0.009304786,-0.00816394,-0.060439862,-0.045394573,-0.032605723,0.043390907,0.059899993,-0.010421065,-0.0087468885,-0.032152794,0.06665533,-0.0043687737,0.05472583,-0.03500818,0.019020924,0.099758945,-0.034186464,-0.102560975,0.03508545,0.05327573,-0.02665639,0.04969231,-0.056205522,-0.016064884,-0.041018803,-0.03833052,0.038111124,0.016490389,-0.008745369,-0.052467316,0.011131069,0.013244828,0.003476653,0.04720614,-0.006079495,0.03190649,0.0063571096,-0.018043429,-0.010155877,0.019040465,0.058882132,-0.01517769,-0.008091137,0.025942538,-0.049091995,-0.03222591,0.027715327,-0.036153212,0.043211587,-0.1276319,-0.12113064,-0.01518277,-0.01614246,0.0060430667,0.007057822,0.018978044,0.05499844,-0.028371872,0.029147202,-0.026314273,0.017470622,-0.05884241,0.0035626467,0.05442842,0.092239566,0.012950235,-0.04551374,-0.029306201,0.04608134,0.090210594,0.004516574,0.014425665,0.027514266,-0.050131094,-0.12293724,0.028043237,0.006640944,0.003929467,0.07079894,-0.017707609,-0.0071467874,0.05901152,-0.05146561,-0.10884493,-0.10667201,0.01352952,0.033327032,0.08613577,0.01745306,-0.015722757,-0.027505802,0.03476459,0.08697409,-0.056905802,-0.01107614,0.10450006,0.039436173,-0.04924085,-0.01585129,0.063294314,0.0044576903,-0.01966136,-0.01995977,0.026002953,-0.053713918,0.08408176,-0.082424976,2.7691952e-33,0.06397886,0.06792654,-0.022818342,-0.02783835,0.025774363,0.018880747,-0.09130097,-0.0012001854,-0.048027188,-0.10188201,-0.011490811,0.008402017,0.016570708,-0.04800026,-0.007846344,-0.04863649,-0.0029627783,0.012928769,0.053490296,0.05149892,-0.03367644,0.037503153,-0.04302454,0.029632222,0.08924454,0.035721745,0.014138424,0.071943216,0.059260584,-0.012847245,-0.019441547,-0.024279399,-0.06914477,-0.030031648,0.05256781,-0.013970924,-0.04736009,0.05303997,0.025590075,0.012365,0.02628918,-0.013646116,-0.03267815,0.02733471,0.059633475,0.02060909,-0.027237102,0.09646953,0.051129777,0.026994884,-0.011642909,0.0063083866,0.01674592,-0.09420496,-0.061136514,0.07933841,-0.018755136,-0.02690283,0.060280934,0.06962825,0.023972536,0.12749499,-0.072431706,0.026833022,0.03142112,-0.03007235,0.011958136,-0.008629934,0.02593878,0.0654221,-0.12864098,0.015872914,0.084752,0.043133594,0.052150458,-0.01136834,-0.074088566,-0.05784131,0.07017733,-0.023564411,0.008990817,0.024718668,0.06453613,-0.09269721,-0.04409434,-0.014260851,-0.05273077,-0.04580859,-0.018295059,0.025672764,0.08244449,-0.10810592,-0.016543945,-0.05455682,-0.0323148,-3.367598e-33,0.07320111,-0.082013085,0.015384875,-0.07504412,-0.027998546,0.07479745,0.006287763,-0.08672523,-0.0005507581,0.030217176,0.07363573,-0.009748493,-0.025247099,-0.05586612,-0.00079828745,0.0013299858,0.016627647,0.043089848,-0.041075114,-0.037462384,0.043503802,0.052753758,0.048201945,0.004353817,-0.00077358715,0.028928261,-0.0018770407,0.060481478,0.12693958,0.025094995,-0.029543,-0.042252973,0.014048397,-0.0024775919,0.004802751,0.030079447,-0.07542338,-0.010172878,0.035941087,0.028960137,-0.051177528,-0.064792976,-0.066263944,0.0042585777,-0.044905476,0.09352183,-0.09899977,-0.06995874,0.021963129,-0.06999435,-0.011906436,0.064331755,-0.04565749,0.018001067,0.036439937,-0.011932922,0.019091908,-0.019478884,0.051410947,0.00014956782,-0.03996745,-0.05653092,0.067382686,-0.0006197677,0.020145472,0.04084814,-0.017733295,0.07318478,0.039534133,-0.0006729556,0.07807817,0.044880815,0.091882825,0.00701608,-0.06415104,-0.013025175,-0.0042731743,-0.062579155,-0.06068964,-0.021979233,0.05072154,-0.025132738,0.015773233,-0.029656477,-0.03844794,-0.108579874,0.052761503,0.016025234,-0.013231341,0.04092939,-0.007917077,0.0707141,-0.005629598,0.04499228,0.09036792,-3.95666e-08,-0.028734224,-0.11492741,0.022071064,-0.044044502,0.00026862015,0.048284285,-0.013215692,-0.028413992,0.016155835,-0.04874906,-0.023498513,0.058773827,0.078505754,0.033682797,0.053031944,0.027548265,-0.029199542,0.0025616423,0.038052652,0.048464786,-0.043174118,0.037572082,-0.13088882,0.011056868,0.021629455,-0.07149685,-0.033901203,0.00510168,-0.0077439793,0.016755203,-0.023759604,0.0065809884,-0.011421072,-0.0143396715,-0.01130126,0.0040614964,-0.12090129,-0.076618254,-0.09516698,0.023396304,0.07912939,0.043376584,-0.1447169,0.06780568,0.0074711945,-0.022178523,-0.0022943697,0.068661295,0.02136249,0.050341893,0.07670712,0.013417875,0.013359467,-0.029223777,-0.07521069,0.050758336,-0.03690337,-0.07648415,-0.04643827,-0.03270239,-0.014891962,0.00976501,0.1732836,-0.0023320343 +1.5.1.52,"The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.",384,1.0,-0.040717345,0.019094955,-0.1258097,0.038338635,0.050815273,0.0198524,-0.013855703,0.01597343,0.0021302921,-0.024872297,-0.022958994,-0.11596309,-0.031544298,-0.026693093,-0.076011404,-0.011928404,-0.11934473,-0.016344536,0.016461728,-0.02316362,0.049996324,0.007683537,-0.042941935,-0.040976986,-0.009400652,0.12345616,-0.017367871,-0.096488245,-0.035645545,-0.036535956,-0.0737843,-0.057422586,0.0904512,-0.040017754,0.062435776,0.073728584,-0.055844866,0.0052496856,-0.01635019,-0.017767668,-0.019838411,0.01440906,0.02644419,0.002749761,-0.025619673,0.016545497,0.10638258,0.032705322,-0.04367306,-0.020424342,-0.013132483,-0.046798717,-0.05811906,0.026769847,0.056141865,-0.0052351034,-0.04802974,-0.07883118,-0.0036985017,-0.05837937,0.086507685,-0.030334966,-0.02030473,0.008203718,0.08827752,-0.029469302,0.061938927,-0.110132575,0.035821144,-0.010512329,-0.026163641,-0.056038264,-0.06014446,0.00037236174,0.017668607,0.07465018,0.10556884,-0.055849165,0.042077485,0.0016271226,-0.00045557893,0.07558987,-0.014835809,0.04836816,0.059110884,0.092198774,-0.015388045,0.017826803,0.009475427,0.02988397,0.015506827,-0.02392988,-0.05375284,-0.03178399,-0.07641388,0.049354203,0.0010060989,0.016543437,0.05288937,0.009871208,0.02202657,0.07799551,-0.0344932,-0.07041554,-0.015231609,-0.048235603,-0.037207514,0.10846252,0.0042557362,0.031181179,0.019053228,-0.0007954506,-0.022005338,0.045055535,0.016439196,0.10523922,0.06312297,-0.055681918,-0.075793475,0.030350309,0.021014953,-0.01841288,-0.039206922,0.0553353,-0.04672237,0.036993798,-0.09995556,1.0664118e-34,-0.027476069,0.0026600957,0.026820831,-0.06846471,0.052476224,-0.027892249,-0.06217561,0.022825688,0.01689907,-0.029927986,-0.054275826,-0.027744485,0.05852952,-0.023217011,-0.020752084,-0.0365552,-0.021664051,0.0716782,0.03759773,-0.035899222,-0.0007782703,0.089639165,-0.022643913,0.045104183,0.041645758,0.08462658,-0.03023691,-0.0032425348,0.030040808,-0.019540308,0.03301934,-0.047437385,-0.045474306,-0.02450447,0.097584754,-0.045435343,0.0032509777,-0.029190578,0.023890708,0.03283112,-0.014000347,0.03391911,-0.028659465,0.08832708,0.042966954,-0.07367657,-0.09418583,0.12543128,0.003946383,0.012963984,0.021209734,-0.016496956,0.08884382,-0.012617366,-0.082534626,0.090731196,-0.038462296,-0.0058299988,0.023902372,0.058421288,0.0052612084,0.09592121,-0.0028746533,0.06384415,0.023992434,0.02291993,-0.00081628904,-0.0046189115,0.015532673,0.08703333,-0.09420863,-0.008343869,0.014931089,0.020919673,0.023136552,0.0017855634,-0.020059055,-0.051453095,0.09274219,-0.01580673,-0.014153863,0.045581076,-0.008424067,-0.08383338,-0.047346357,-0.03858188,-0.04853389,-0.08158635,-0.04112575,0.05482697,0.00014422505,-0.019180315,-0.07886432,-0.014769865,-0.03569822,-2.0909319e-33,0.07249877,-0.13808043,0.020517416,-0.10141067,-0.07769651,0.04674761,-0.061946373,-0.07070274,-0.0019533685,-0.009290655,0.07237335,-0.011289057,0.07963046,0.032022692,0.010352129,-0.010429792,0.009476133,0.104531445,0.036288124,-0.0059125125,-0.03173459,0.058480605,-0.01602225,-0.045197237,0.0131694125,-0.0005673408,-0.044575274,0.050132733,0.063485935,0.0058975257,0.035283525,-0.03297656,-0.011625035,-0.030865472,-0.057110343,0.0728472,0.02498402,0.027322635,0.12726124,0.030198153,0.05372116,-0.015599286,0.006259235,0.07974869,0.053912707,0.046669804,-0.13683455,0.061622087,-0.016651146,-0.04408455,0.08761489,0.038537048,-0.0080712205,-0.0050940914,0.010226373,0.07590745,0.017115545,-0.054817617,-0.018592142,-0.0011154576,-0.056802724,-0.074581385,0.0436562,0.041688774,0.032280385,0.00036132973,-0.015389322,0.05186304,0.0067774937,-0.032189853,0.0783365,0.07726372,-0.043979947,-0.029421577,-0.06357211,-0.06537409,-0.0326212,-0.025084756,0.044823218,-0.035639964,-0.031047627,0.05440299,0.10165869,-0.0011151307,-0.030873176,-0.08184682,0.08788702,0.15058571,-0.0029801573,0.034763563,-0.052206308,-0.051581096,-0.04472762,0.050800923,0.010489199,-3.359855e-08,0.013457214,-0.022448191,0.066777386,-0.026405359,0.0066501936,0.10187115,-0.007245225,-0.062320627,0.030912101,-0.050587654,-0.021072423,0.031258725,-0.002823124,-0.061992016,0.016447239,0.03559596,-0.03169154,-0.07367475,0.0021504152,-0.018204607,-0.04657191,0.010161019,-0.053109676,0.02017382,0.011224327,-0.047295164,0.06846596,0.04235927,-0.110328734,-0.01654161,-0.049119476,0.006833315,-0.031427357,-0.0068533714,-0.056128453,-0.029124161,0.0018153568,-0.063186705,0.01411505,-0.0045556882,-0.026794443,-0.008210903,-0.0719752,0.028591866,-0.062938906,0.020868737,-0.026222534,0.035772353,-0.011891676,-0.0145278275,0.04360069,-0.019221164,-0.027779208,-0.038343187,-0.065298915,0.033312805,-0.008182193,-0.070490986,-0.06849138,0.04726152,0.042034734,0.037729595,0.16401866,0.0025256823 +1.13.11.87,"The enzyme catalyses the cleavage of the double bonds in natural and synthetic rubber, producing a mixture of C20, C25, C30, and higher oligo-isoprenoids with ketone and aldehyde groups at their ends. Two unrelated bacterial enzymes are known to possess this activity - the enzyme from Streptomyces sp. K30 (Lcp) contains a b-type cytochrome, while the enzyme from Xanthomonas sp. 35Y, (RoxB) contains two c-type cytochromes. Both enzymes attack the substrate at random locations, and are not able to cleave the C35 or smaller products into shorter fragments.",384,1.0,-0.03139808,-0.057786427,-0.05004897,-0.031818595,0.043729436,0.017952545,-0.05777337,0.0645548,0.0044416874,-0.0038575893,0.045826357,0.0053282697,0.02909645,0.046621233,0.012375029,0.044796318,-0.06327914,0.014918189,0.048990216,0.008826168,0.07797505,-0.00720722,0.016203139,-0.048304092,0.050892934,0.05839767,0.059704438,-0.04835988,-0.042385694,-0.076590255,-0.0014052781,-0.03424361,0.043665342,-0.08750582,0.14601438,0.03328839,-0.11138682,-0.061678294,0.10249151,-0.0024734132,0.012632607,-0.017806262,-0.05236096,0.005601123,-0.060363486,-0.04337166,0.014652853,0.051167753,-0.007084882,-0.0523243,-0.023876198,-0.097849056,-0.041466895,0.037283566,0.021872092,-0.0358776,-0.11849996,-0.011172553,0.029465953,-0.038056795,0.12320568,0.044510182,0.020650648,0.017244935,-0.025006048,-0.07031765,0.037185717,-0.0403352,0.04129061,0.03733042,-0.087064475,-0.0012909627,0.027515689,0.036967173,0.07679113,-0.029479472,-0.030251022,-0.0053289337,-0.04692288,-0.010435047,-0.032282583,-0.0034458525,0.019253308,0.08796676,0.06537861,-0.027904922,0.059102695,0.037898973,0.035513785,0.07900668,-0.0022974424,0.042340267,-0.010978667,-0.06909879,-0.07334647,-0.01329654,0.0013679953,0.09912262,0.024943022,-0.017988486,-0.043032896,-0.001396124,0.040109,0.00019000727,-0.0066067576,-0.0467947,-0.04754607,0.005430883,0.07892703,0.003816564,-0.003607988,-0.010623164,-0.0024368188,-0.061082378,-0.034468442,0.06612875,0.08700321,-0.039956525,-0.043595184,-0.020948352,0.01859622,-0.057982154,0.03431896,0.023642186,-0.053016305,-0.0008887325,-0.13857271,2.332979e-33,-0.026285158,0.043255847,0.010804783,-0.067757085,0.0021550097,-0.0388142,-0.077459544,0.04834173,-0.04825034,0.011593765,-0.11480928,-0.037880793,0.058577035,0.0149242,0.030058486,0.0628484,-0.026928721,0.04530972,0.04495462,-0.0053675906,-0.00629176,-0.017182767,-0.03877688,-0.0073840534,0.03347549,-0.01231486,-0.019015066,-0.020743929,0.07208985,-0.01540174,0.016370561,-0.048876844,-0.05822948,0.05055787,0.056111794,0.028809164,-0.032093447,-0.0560694,-0.036634874,0.01494955,-0.021886101,-0.010652403,0.038657267,-0.027414266,0.027330939,-0.04744743,-0.10873093,0.07224847,0.051116724,0.019999927,0.096324414,0.0031380146,0.04077645,0.030153949,-0.0633258,0.08070442,-0.0045690383,-0.019184608,-0.044532157,0.040382873,0.025378972,0.04522922,-0.00092982256,0.022721838,0.018342659,0.042848006,-0.01600194,0.013688281,0.014048848,0.0753301,-0.12017261,-0.035103586,0.04829811,-0.025232242,0.014391609,0.0027752102,-0.017667888,0.0081213545,0.10776331,0.030373825,0.017302046,-0.07018397,0.03712483,-0.11350531,-0.09918247,-0.006484186,-0.07716432,-0.076362364,0.05403773,0.12256193,-0.030938929,-0.1375285,-0.10536312,0.07833311,-0.040100228,-4.4261216e-33,0.08519836,-0.065737665,0.0733337,-0.05245483,-0.08460536,0.08974918,-0.03680661,-0.02112297,-0.024799952,-0.060733113,0.08415903,0.0070097926,0.021415971,0.056740005,0.0068929945,0.0027699948,0.009073723,0.117060244,-0.024459472,-0.005742616,-0.0018783505,0.056920286,0.0012858731,0.004554666,-0.024682201,0.056970973,0.03409582,0.060083896,0.04759015,0.021532658,0.016015736,-0.042568743,-0.027904477,-0.050761733,-0.017609108,0.051206082,-0.084871545,-0.007657793,0.10099501,-0.038522083,0.05656586,-0.01343046,-0.012308164,0.037363905,-0.003439931,0.010252946,-0.020822428,0.024599388,0.027560782,-0.081622496,0.07228817,0.03712728,-0.06712354,-0.01539983,-0.019558512,0.08129802,-0.023795411,0.0162439,-0.0058576707,-0.017054105,-0.02059161,0.008354396,0.038016,0.0075112428,0.0809,-0.025976794,-0.04316157,0.05302187,-0.0020530184,-0.032051265,0.016119838,0.042005423,-0.035339158,0.04305671,-0.040610038,0.007932567,-0.013903803,-0.07218958,-0.0013532098,0.009660984,0.041706327,0.017910058,0.031783685,-0.04389969,-0.024968326,0.008931068,0.016343586,0.09858894,0.07377048,0.023231123,0.0014592134,0.05748582,-0.009729301,0.099432446,0.07895743,-4.5394295e-08,0.020265803,0.017545847,0.026143912,-0.03736012,-0.019047426,-0.010356695,-0.038376432,-0.06656169,0.015480092,-0.081735514,-0.04833241,0.062175047,-0.043187503,0.005872609,-0.011563383,-0.021486199,-0.09788223,-0.038703248,-0.023824444,-0.047556654,-0.13975312,-0.052876156,-0.0015710135,0.063162796,-0.006946571,-0.11283438,0.039914396,0.094016746,-0.0012281648,0.004225301,-0.041520715,0.025565868,-0.04393668,0.024073556,-0.036174115,-0.010591588,-0.034764286,-0.057076644,-0.020822275,0.0589216,0.06348471,-0.103997804,-0.071135394,0.009451346,-0.031438727,0.028471084,-0.002230685,0.01279669,-0.05793038,0.028966496,0.019090941,0.042171814,-0.032567263,-0.020399157,-0.06810166,0.00060361676,-0.015524837,-0.012768518,-0.068308964,-0.06120105,-0.024238585,-0.06446122,0.20810585,-0.00444622 +1.14.11.60,Requires iron(II) and ascorbate. A protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.,384,1.0,-0.028379142,-0.034782916,-0.1419004,0.06657256,0.106759794,0.05904186,-0.044389714,-0.035735242,0.06951581,-0.023589885,0.06269806,-0.017349683,-0.119241625,-0.08666778,-0.032653965,-0.051709834,-0.003297009,0.028082523,-0.09058345,-0.02513175,0.042044636,0.038361594,0.02981448,-0.0029985805,0.0034285616,-0.05934644,-0.063717745,0.018257644,0.018674867,-0.015237163,-0.0091945985,0.027831709,-0.011592756,-0.026491702,-0.025049081,0.035770256,0.0101371575,-0.1567279,0.07285665,0.0059892996,0.0015868511,-0.007979941,-0.03603057,-0.06537806,-0.015636884,-0.056166884,-0.0130549725,0.018094186,0.027998012,0.02151891,-0.033880547,0.07793796,-0.05003888,-0.061450064,-0.06759534,0.024322443,0.010469915,-0.02131258,-0.015961625,0.05880062,0.017900892,-0.03181574,-0.04371029,-0.001762892,-0.037177596,-0.015878879,-0.048068,-0.002157037,0.05733464,0.0055131637,-0.0019343275,-0.060945638,-0.03486827,0.016822292,-0.060448874,0.12203158,-0.02236368,-0.02944193,0.02651515,-0.0447155,-0.004278322,0.068344034,0.034003597,0.07169659,-0.008842308,0.034694057,-0.010464066,0.040411156,-0.04835687,0.07043597,0.030742053,0.0135119995,0.03563858,0.024703,-0.050865356,0.05692784,0.13082774,-0.03537846,-0.031441722,-0.057563905,-0.06647836,0.04789747,0.03233062,-0.012842471,0.011163447,0.008265819,-0.10275716,0.0792094,0.053840805,0.0016302002,-0.005170113,-0.020667786,-0.035842817,-0.05135297,0.058902096,0.11174141,0.040233348,-0.07033408,-0.051246095,0.003657056,0.068084,-0.013432897,-0.03331519,0.08335769,-0.015462536,-0.047681585,-0.010813782,-1.3292618e-33,0.045780756,0.07703214,0.00026223317,0.06291035,-0.06213581,-0.02168662,-0.10369304,-0.043717034,-0.0048682936,-0.05304819,-0.04225452,-0.07371094,0.017977212,-0.03726255,-0.011197612,-0.0630178,-0.0033721332,-0.08222139,0.10178914,0.052537825,0.03737094,0.08204904,-0.032344364,0.029434726,-0.027877295,0.061888665,-0.039772168,0.04953087,0.0068936097,-0.023883332,0.09511887,-0.086671405,-0.03184542,-0.0065939873,0.10327898,-0.0015919862,0.021682497,-0.046041146,-0.05167719,0.041585095,0.05441614,0.021268405,-0.015549388,-0.0058676824,0.08435433,-0.036985997,-0.057727657,0.029178156,-0.02548113,0.041524474,-0.01450481,0.09726076,0.15042989,0.08735355,-0.0029574023,-0.0391588,-0.01057359,0.012953585,0.01777344,0.093259886,-0.005342434,-0.06665364,-0.019497164,0.11354999,0.004625905,0.028882286,-0.049824487,0.051473588,0.037316814,0.07268325,-0.028774017,-0.049041018,0.02219089,0.018143635,0.07006998,0.028324047,-0.025434837,0.037209697,-0.02869251,0.059472054,-0.047782727,0.0028217488,-0.050457854,-0.0112792235,-0.07623586,0.028683731,-0.0368458,0.023798734,0.06269444,-0.07728471,0.07891913,-0.0009923668,0.029271875,-0.024604384,-0.008102615,-1.7490992e-33,0.038912307,-0.051827382,0.011383454,-0.00919629,-0.1084275,0.06653819,-0.0026649593,-0.16552019,-0.07143331,-0.01094652,0.031711712,0.038521327,-0.008669829,-0.05950872,-0.034650054,0.022152042,0.0183406,0.095980115,0.04331978,0.06260928,-0.009410763,0.04602356,0.074053735,0.010596099,0.0507707,0.021857642,-0.028591897,-0.111655265,-0.045668688,0.031933542,0.0686356,-0.05082948,-0.027023181,-0.083770104,-0.0031552408,-0.035498455,-0.019267589,0.013095063,-0.033900037,0.0021113004,0.0044715535,-0.030826032,0.047993585,0.07047984,0.07064459,-0.030517507,-0.102352045,0.054451223,-0.03817151,0.0708874,0.007128068,0.0146757,-0.07279714,-0.01709535,0.044025384,-0.049491,0.10474768,0.01756388,0.039826803,0.07728954,-0.04445856,-0.021864088,0.008122855,-0.010331342,0.044242937,0.060781635,0.025332531,0.085056044,0.038013138,0.0019848857,0.019007236,0.010910387,0.08601122,-0.004508808,-0.014034943,0.011933344,0.016314631,0.039286204,-0.06274245,0.007122703,-0.08956315,-0.047289547,0.009076948,-0.01212603,-0.06196829,-0.08413666,-0.014820916,-0.019269092,0.006851443,-0.00436348,-0.057652608,-0.08023625,0.0134179555,-0.013937603,0.052595135,-2.4802349e-08,-0.049865108,0.01875161,0.036905613,-0.09363318,0.051671453,0.03727876,-0.039348107,-0.0840264,0.025385521,0.040759776,-0.0009347592,0.06920728,0.04168561,-0.006319277,0.004646468,-0.059023395,0.050279416,0.047868118,0.0149088325,-0.025744777,-0.091590896,0.027822306,-0.08861591,-0.010617922,0.01803096,-0.0998934,-0.036678016,0.0152749615,0.09912433,0.027796695,0.031388726,0.0086178575,0.027908262,-0.040277775,-0.025091857,-0.00359608,0.023056425,-0.017056337,-0.04535386,0.027790066,-0.10579962,0.014324683,-0.03045914,-0.013386537,-0.023865854,0.015355993,0.050453015,0.050124273,-0.023123655,0.030028762,0.004134282,-0.06209968,0.044131905,-0.09065531,-0.1066605,0.01734475,0.04017747,-0.05416988,0.025837976,0.0024151248,-0.040925853,0.0056794332,0.057155777,-0.04195474 +1.14.12.26,"This bacterial enzyme is a class IIB dioxygenase, comprising three components - a heterodimeric terminal dioxygenase, a ferredoxin protein, and a ferredoxin reductase. The enzyme acts on a range of aromatic compounds, including mono-, di-, tri-, and tetra-chlorinated benzenes and toluenes.",384,0.99999994,-0.11196846,-0.034126855,-0.086360104,-0.016669199,0.03160748,-0.004114848,-0.03428314,0.0393168,-0.04104467,-0.069907665,-0.042736925,-0.06866824,-0.028340539,0.054389924,-0.048837382,-0.0030614336,-0.058285493,-0.04370166,-0.0057704463,-0.0010546542,-0.024988638,0.11116138,-0.033678573,-0.031118432,-0.01641107,0.023418939,0.089842826,0.02110476,-0.05298482,-0.07953906,0.059601158,0.019937485,0.03355182,-0.03956132,0.031917036,0.063614205,0.012804587,-0.048949547,0.09772933,0.010572712,-0.011104047,0.06249199,0.0157428,0.0037728671,0.008200598,0.0061221286,-0.0014512261,0.0066726226,0.04787114,-0.067926995,-0.05226919,-0.026958758,-0.036072608,0.12543987,0.05934409,-0.037455622,0.014623439,-0.029698115,-0.07457257,-0.037112165,0.03610765,-0.0036688077,0.052988652,0.044455282,-0.014630355,-0.010864703,-0.030984141,-0.078391805,-0.0067329477,-0.08718189,-0.075433604,-0.0457498,-0.020327955,0.040248632,-0.005365866,-0.01732014,0.044564705,0.02344099,0.06896113,-0.03256373,-0.012233998,-0.023346584,0.05523582,0.100986466,0.01834101,-0.0672859,-0.017414704,-0.017363222,0.011168086,0.07201279,0.026797988,0.016063958,0.026429432,-0.0429273,-0.06231403,-0.028390879,-0.034485016,0.042259555,0.0471953,0.008713517,-0.04555773,-0.0019066107,-0.020015152,-0.114048526,-0.09642469,-0.053923834,0.04370129,0.09356499,0.07750052,-0.026603982,0.009884897,0.0024605808,0.04606208,-0.046509277,-0.019749561,0.059731986,0.081237435,-0.058086004,-0.028293962,0.025692683,0.049740754,-0.029108917,0.05399612,-0.0024855388,-0.080423556,-0.013974209,-0.11922613,-1.9102432e-34,0.03163767,0.0006005238,-0.045740046,0.0030692643,0.014397671,0.010434969,-0.05953161,-0.028009817,-0.07978735,-0.015352105,-0.077516325,-0.035278887,0.04367352,0.022660589,0.027580578,-0.045179598,-0.056420308,0.017460946,0.043659788,0.025041692,0.050181516,0.0712038,0.00768404,0.0041365223,0.109766126,0.090116255,0.026504094,0.02972072,0.0184242,0.023650436,0.06989784,-0.07449296,-0.08993219,-0.0341496,0.03726772,-0.03940872,-0.047360223,0.031871583,-0.024891991,0.0024505835,-0.007748544,0.030088304,0.0039826324,-0.029589819,0.050647426,-0.039463613,-0.026155533,0.13105243,0.04416274,0.091877975,-0.00023139604,-0.020027282,0.07395735,-0.09936035,-0.05920331,0.08636021,0.030600637,0.09909095,0.054361846,0.055046223,0.0105949845,0.08199196,-0.094288915,0.042500082,-0.018295994,-0.001114135,-0.02345093,-0.040249135,0.053739358,0.07950387,-0.026535576,-0.0076303077,0.07827156,-0.014490021,0.0321178,-0.05014511,-0.046426304,-0.038429543,0.07986292,-0.014512962,-0.035669643,-0.048785314,0.019748678,-0.08671031,-0.057410553,-0.00842921,-0.0445845,-0.014955518,-0.05916676,0.054881196,0.081793405,-0.051923126,-0.08064206,-0.031078637,0.02617204,-2.6094654e-33,0.100646146,-0.049892254,0.014978368,-0.094921395,-0.029288247,0.07919217,0.009702519,-0.00097391277,0.0017428538,0.059367113,0.09481219,0.032924272,-0.00016812398,0.0040912004,0.027643504,0.04087083,-0.021068217,0.022460457,-0.009198265,-0.049322806,0.07776822,0.005412814,0.02173401,-0.023155754,-0.038659398,0.049525354,-0.05484016,0.11138451,0.08952579,0.036862373,-0.06634422,0.0008939127,-0.0035235318,-0.0802131,-0.07352239,0.056264274,-0.06052299,-0.054266326,0.006165029,0.0141217485,-0.0009635196,0.022657895,-0.02067675,0.09931763,-0.015286282,0.039065983,-0.097969964,0.041474566,0.033196855,-0.024312237,-0.046678204,-0.007866008,0.015718978,0.023140535,-0.0055213086,-0.008591814,0.0023141669,-0.0037322524,-0.06900808,0.039723042,0.0022550002,-0.0825048,0.060943067,0.064802,0.010410565,-0.00506261,-0.048527982,-0.0063823583,0.04267897,0.0023651985,0.058198795,-0.0077818925,0.0136691015,-0.008532339,-0.037358195,-0.042926222,-0.029486973,0.029910296,0.031127645,0.047395412,0.008008259,-0.03117215,-0.009405089,0.016670816,-9.300704e-05,-0.13157193,0.014993973,0.073055014,0.03323475,-0.0005239263,-0.04746681,0.08109264,-0.0033844202,0.008337253,0.05487395,-3.8366288e-08,-0.026946742,-0.13356155,0.070262395,-0.02602125,0.017781774,0.030548252,-0.035158914,-0.0034121855,0.028917879,0.0067292196,0.06265667,0.10855766,-0.02564987,-0.034647282,0.039854944,0.06647633,-0.063187554,-0.03274223,0.002247561,-0.01969451,0.015590699,-0.058866803,-0.036734276,0.035910472,-0.003272268,-0.057432137,-0.04563508,-0.0064510014,-0.0014525312,-0.01005462,-0.07875562,0.09078512,-0.070177406,-0.07253035,-0.1428511,-0.0072577205,-0.08837026,-0.036447965,-0.034548167,0.038738374,0.045511816,-0.0022758665,-0.12449812,0.011375538,0.056661543,0.050574366,-0.042783722,0.027537176,-0.032467093,-0.05869263,0.029149985,0.0055681174,-0.012410224,0.047792755,-0.117853016,0.09707399,-0.038927376,-0.020363593,0.007918372,-0.006400523,0.013768848,0.070811845,0.119183205,-0.036342286 +1.14.14.159,"A cytochrome P-450 (heme thiolate) enzyme characterized from maize. The enzyme catalyses the epoxidation of dolabradiene at C-16, followed by hydroxylation at C-3.",384,1.0,-0.07027908,0.07483998,-0.050202824,-0.031466804,0.05385229,0.049663343,-0.020864153,0.08541296,-0.037425775,0.038404737,0.039387003,-0.046262924,-0.044819683,-0.040524576,-0.055980977,0.03780411,-0.019643309,0.060609158,0.010406036,-0.10645563,-0.029508088,-0.0064250245,0.044417497,0.05062509,0.039866745,-0.014201099,0.0030570375,0.033632655,-0.067464225,-0.03390627,-0.04386757,-0.006891478,0.06020053,0.0014624406,-0.028290492,0.10737112,-0.053060636,-0.060576543,-0.01560304,-0.07207426,0.028208435,-0.017993635,-0.07442183,0.009857598,-0.055692147,-0.039879035,0.005148022,0.034191955,-0.031024365,-0.0433746,0.023453811,-0.04923701,-0.08355215,-0.020098351,-0.051364362,0.033259824,0.04116629,0.01962992,-0.012469968,0.079635166,-0.04752201,0.027888594,-0.087768175,0.03981362,0.042848784,-0.013849785,-0.038857944,-0.013124838,-0.08614933,-0.05854527,-0.020364532,-0.09602599,-0.0082746595,0.009040333,-0.10875443,0.05731367,-0.036641948,0.026985623,0.04790171,-0.004718638,0.04345722,0.0071653933,-0.016324636,0.08499703,0.02715622,0.013175217,-0.0669711,0.083295844,0.041771546,-0.028385911,-0.00036988573,0.034085233,-0.11705793,0.05060441,-0.06680711,0.0852219,0.070719264,-0.032288216,0.06329299,-0.009441239,0.08596692,0.055569425,-0.025468031,-0.09431048,-0.041936636,0.008765918,0.015395997,0.020971172,0.0725542,-0.031343862,-0.021011459,0.0028192974,-0.006010063,-0.010225563,-0.04560541,0.07160184,0.0035237954,-0.061958242,-0.01564809,-0.037930626,-0.03947221,0.02891263,0.006818187,0.0075543877,-0.035195783,-0.033383906,0.018677795,3.108341e-33,0.022359127,0.07618955,-0.012711866,0.0186017,0.013512442,0.044268403,-0.05560986,0.06529366,-0.0770425,-0.010322895,-0.08377306,-0.10995456,-0.0021674715,-0.026959648,-0.006951985,-0.010816806,-0.04559226,0.04290717,0.032784082,-0.022393113,-0.061661337,-0.054232612,-0.058634315,0.019928725,0.033382542,0.10171376,-0.05554502,-0.009745329,0.05327208,0.0023922774,0.029245168,-0.027212285,-0.054230828,-0.049951702,-0.0234701,0.03400488,-0.032697257,0.0046878066,-0.05449017,0.08037008,-0.040320072,-0.006111929,0.054052114,-0.09485836,0.074342325,-0.06574651,-0.07583336,0.0547375,0.035086878,0.059846446,0.06502567,-0.06177693,0.072231576,0.03681003,-0.06462983,0.057656653,0.013182107,0.047209196,0.0038454845,0.050144654,0.113294914,0.08990909,-0.05741783,0.0028087946,0.025538314,0.059824895,-0.069963634,-0.0065194257,-0.0025107595,0.13158709,-0.026428161,-0.041752823,0.039153636,-0.040494405,0.01409925,0.019585289,-0.020176494,0.07579418,0.0274144,0.032668468,0.015854344,-0.00083804765,-0.011518802,-0.04544319,0.010005594,0.01634108,-0.020914309,0.014774342,0.0060810614,0.06503193,0.09511559,-0.09157189,-0.0060241483,-0.012483793,-0.023426643,-3.145509e-33,0.06922795,-0.02905311,0.04610278,-0.083087936,-0.0017308425,-0.012899474,-0.029799474,-0.012169961,-0.014707589,-0.023876373,0.10061863,-0.042186793,0.010094749,-0.036088362,0.009353281,-0.0063607893,-0.038010295,0.08810719,-0.0036644526,0.094598204,-0.004350202,0.021612106,-0.0077411393,-0.0045394935,0.02183165,-0.01351269,0.030317334,-0.00015536681,0.11760215,-0.025080124,-0.051141273,-0.036833845,-0.037286337,-0.01126136,0.06509713,0.040569182,0.010448797,0.044939842,0.040065635,0.053471144,-0.06730301,0.080640964,0.0027258447,0.023717104,0.0065583475,0.14517704,-0.12090361,-0.029764516,-0.0025531512,-0.0015304027,0.0536714,0.0135892695,-0.062208384,0.034999076,-0.018052083,-0.028082905,-0.015490591,0.0019529002,-0.05851636,-0.10264684,-0.035091944,-0.02875717,0.0113017075,0.057151373,0.039979935,0.072006404,-0.12654199,0.07600774,-0.022170387,0.026608702,0.011735246,-0.012914737,-0.015190537,0.023531629,-0.041163072,0.020724412,0.026039885,-0.015188543,0.03744304,0.013277247,0.05877973,0.023406351,-0.036230586,-0.032483928,-0.024913017,-0.07633952,-0.087371305,0.118664116,0.07650319,-0.0058475197,-0.028297536,0.0465252,0.004360796,0.044199422,0.110948406,-3.103888e-08,-0.0122959865,-0.123661175,0.0063564396,-0.012256941,0.010759648,0.021620441,0.049937416,0.0063689025,0.081312835,-0.05412323,-0.044314615,0.096827984,-0.028936945,-0.032024663,0.0060643586,-0.015966667,0.016158497,0.0037722068,0.03419424,0.051589824,-0.03628074,0.031293113,-0.035695564,0.040271617,0.06619725,-0.086416185,-0.024814423,-0.011615003,0.03147835,0.027287792,0.031033615,0.057013426,-0.01885512,0.0027758023,0.00012244115,0.0110059185,-0.03022853,-0.03417903,-0.04158381,-0.016325364,0.032963797,-0.06228536,-0.043836217,-0.048481043,-0.016047632,-0.010516209,0.053704888,0.04427304,0.010319381,0.023714548,-0.0601309,0.00858234,-0.011753756,-0.13795935,-0.09181745,-0.02418237,0.08624214,-0.03094211,-0.0365229,-0.10572477,0.037364606,0.01775388,0.21397467,-0.025296845 +1.14.14.160,"A cytochrome P-450 (heme thiolate) enzyme characterized from maize. The enzyme sequentially oxidizes(S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1, a maize phytoalexin that provides biochemical protection against fungal infection.",384,1.0,-0.06456672,0.055817667,-0.036436122,0.016173616,0.077447206,0.058006637,-0.087439574,0.065981515,0.010944464,0.014551316,0.07517293,-0.01950929,-0.04885676,0.003436835,-0.07638749,0.024173228,-0.022505544,0.052420616,0.03261286,-0.06703009,-0.0035345324,0.12785266,0.009728706,0.029523505,-0.009344936,-0.05029352,0.04076,0.08750201,-0.0653384,-0.028468532,-0.077578634,-0.030786082,0.0133427745,-0.013055699,-0.06115945,0.07921798,-0.047697835,-0.0664533,0.050044723,-0.055655207,0.02402412,-0.04891029,-0.08286379,-0.0086883055,-0.0543634,-0.01992133,-0.019635946,0.042394083,-0.00096835854,-0.095463894,-0.0058982032,-0.04713967,-0.04283315,0.012434704,-0.028250162,-0.008811395,0.033849157,-0.04116963,0.004614881,0.06543209,-0.026231498,0.0445477,-0.017195141,0.019724652,-0.007819346,-0.018798223,-0.038682096,-0.0039885906,-0.06915122,-0.09259867,-0.08529142,-0.099006645,-0.018330097,-0.01837194,-0.05296154,0.06751179,-0.059934195,0.014037921,0.02701431,-0.00095141475,0.06905174,0.015225414,0.072209716,0.100571506,0.05364948,-0.011476697,-0.038756445,0.10041253,-0.0064374222,-0.014787128,0.037347406,0.041633554,-0.031691294,0.05869925,-0.072056204,0.048517477,0.06116542,0.016454613,-0.00074770226,-0.014614515,0.05075934,0.019342527,-0.059607964,-0.055511195,-0.026099302,0.025747638,0.0646755,-0.013168209,0.05941925,-0.016529506,-0.029445982,-0.0076894565,-0.066358805,-0.088249385,-0.044569504,0.033200722,-0.008748818,-0.005707478,-0.0035688805,0.016717667,0.037109274,0.017025387,0.009270731,-0.012169093,0.005012448,0.017217252,-0.015788043,2.4132546e-33,0.008689783,0.08543976,-0.070478484,0.029750941,0.057301976,-0.035088673,-0.021727571,0.032032233,-0.04514928,0.0043798913,-0.052102037,-0.042503282,-0.053109657,0.013662072,0.007974137,0.0659946,-0.09249429,-0.018493038,0.05096769,0.018330172,-0.043233484,-0.08887048,-0.05997607,0.024937598,0.055349223,0.08483616,-0.04934687,-0.025139662,0.024719747,-0.005149439,0.024826672,-0.038084093,-0.06656903,-0.08981432,0.03303254,0.008785293,0.003568763,-0.017198395,-0.121424876,-0.0014901919,-0.077871464,0.037698578,0.020846376,-0.096914604,0.07081108,-0.008928703,-0.11678046,0.09066473,0.042281248,0.03250726,0.07519807,-0.0756129,0.060738675,0.04236513,-0.064016476,0.04075953,0.00043607855,-0.0014742821,-0.014840584,0.05992071,0.09016968,0.063936755,-0.0509785,0.058676966,-0.009887383,0.016999666,-0.05205039,-0.03695616,-0.0031403548,0.118854925,-0.038722448,-0.027009005,0.04996403,-0.050075054,-0.0606606,-0.005958166,0.0101916455,0.0038182882,0.03576227,0.007398546,0.052937437,-0.07079473,0.03706606,-0.06186121,-0.018569084,-0.0013089279,-0.03499382,0.022173086,0.03288976,-0.008552999,0.07124392,-0.0412134,0.0044058915,-0.0036860306,-0.02579819,-2.7803687e-33,0.09961778,0.025187925,0.065577425,-0.05802852,-0.039762218,0.051199958,-0.038175225,-0.02497205,-0.006082647,-0.027338488,0.044008654,0.005363662,0.036161374,-0.005395978,0.022408884,-0.021498267,-0.048916195,0.04857024,0.03362953,0.033764306,-0.04335186,0.037510853,0.0001866383,-0.0073692068,0.051751196,-0.0020862161,0.007556854,0.0753919,0.06877579,-0.043313548,-0.028834797,-0.0033605583,0.016774418,-0.026686883,0.005693451,0.08071012,0.017807972,0.045170657,0.04263338,0.09823326,-0.029864928,0.02689626,-0.052051865,0.028011989,-0.012041293,0.12106645,-0.08422455,-0.0021697178,0.0476229,-0.04311144,0.09602599,0.06281893,-0.070602074,0.032980923,-0.021731865,-0.008612203,0.009233588,-0.022803264,-0.035332147,-0.06699521,-0.016465383,-0.0013148625,-0.010331739,0.06084506,0.037618127,0.038562518,-0.057730276,0.05212246,0.07284797,0.010606148,0.0003586553,0.051410384,0.021256305,0.014882397,-0.047444392,0.027458813,0.018644463,-0.030545905,0.027346602,0.062904686,0.08021495,0.021169022,0.007679389,-0.058377013,-0.047796343,-0.09834312,-0.032197647,0.15435296,0.027481813,-0.04972579,0.0014306417,0.07322478,-0.009720331,-0.0007603978,0.024329705,-3.4498175e-08,0.024317672,-0.058132503,0.007588683,-0.05702661,0.007999938,-0.027268622,0.060800627,-0.013471788,0.06873469,0.005757756,-0.037348192,0.11493542,-0.03859619,0.010803866,0.011211258,0.0033096147,-0.036732215,0.02040328,0.01346122,0.06101168,-0.04563259,0.04452774,-0.0804128,0.0018020339,0.034699608,-0.13002142,-0.022923218,-0.018846767,0.04866989,0.04621266,0.009271247,0.06127399,-0.010562775,-0.045704488,-0.07620232,0.026783412,-0.07676304,-0.050506737,-0.027402153,-0.03695564,0.018238297,-0.10420828,-0.06365451,-0.06857353,-0.017071066,-0.03747034,0.030131292,0.02827505,-0.0012403264,-0.0046387105,-0.01328303,0.022933872,0.021327645,-0.06339376,-0.08499947,-0.011157179,0.098384716,0.0026656562,-0.034300346,-0.170651,0.02427662,-0.0032847777,0.24423996,0.0052193236 +1.14.14.161,"The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme thiolate) protein. It catalyses three successive reactions in the pathway leading to biosynthesis of monoterpenoid indole alkaloids.",384,0.99999994,-0.016075911,0.00017558142,-0.08709329,-0.025743747,-0.054889854,0.08843506,-0.049317587,0.033618763,0.059128795,0.0078590885,0.01331423,-0.03377346,-0.054934826,-0.030405411,-0.049237642,0.07893488,-0.0646005,0.046935566,-0.0035779784,-0.08798299,0.023262547,0.07476049,0.023969064,0.0012328357,0.060068924,0.03680831,-0.01006192,-0.018683862,-0.028994387,-0.054357562,-0.0122736525,-0.00027090448,0.03711023,0.009952659,-0.01668842,0.070702925,-0.07398338,-0.049650226,0.057204116,0.01569556,0.052388757,-0.03462707,-0.03664928,0.0034975084,-0.037044812,-0.0053083454,-0.012020574,0.011129082,0.026204593,-0.046893254,0.013551042,-0.032163985,-0.046942733,0.007032216,-0.02669774,-0.09059889,0.054838426,0.048669968,-0.06639209,0.018783784,0.036463514,0.04459262,-0.018221224,0.055750012,-0.005612484,-0.06932763,-0.05222404,-0.019637875,0.02228339,-0.074108556,-0.00520014,-0.11197704,-0.067980565,-0.046539035,-0.07238714,0.06699031,-0.009150312,0.022377884,-0.04333035,-0.064345434,0.09526068,0.068265766,0.027662542,0.17020525,0.025754156,0.03625228,0.019649819,0.034561377,0.03391543,-0.02962883,0.057444345,0.007266656,-0.030261757,-0.016851045,-0.09869343,0.06755542,0.032992754,-0.006684061,-0.04215747,-0.015852539,0.052840296,0.055709243,-0.0652493,-0.076962985,-0.10299833,-0.004895346,-0.03860735,0.008266637,0.016700385,-0.048532594,0.014607984,-0.042358756,-0.0074595823,0.019935643,0.008651255,0.062029306,0.00079301244,-0.04637557,-0.010656886,0.00949506,-0.06912695,-0.0014522964,0.04387555,0.06505697,-0.041508153,-0.010137812,-0.08495915,3.257763e-33,0.096680775,0.057045523,-0.03007673,-0.059373047,0.0112471515,-0.03994132,-0.05172993,0.05954417,-0.07917689,-0.018180732,-0.105524205,-0.03547481,0.029918894,-0.057926755,-0.010133484,-0.025922295,-0.05098019,0.038656104,0.074008085,-0.026042553,-0.056109887,0.014217754,-0.079772435,0.021464743,-0.023146374,0.057649814,0.025232688,-0.024935303,0.020404072,-0.014549098,-0.018180544,-0.099295504,-0.05677433,-0.017004304,-0.052699458,-0.053299733,-0.036548838,0.018474743,-0.058015287,0.051556155,-0.014381703,0.05506909,0.027721027,-0.008363541,0.07707892,0.020202221,-0.08080496,0.09412634,0.03380622,0.05207336,0.016367957,-0.022687593,0.17182483,0.08035757,-0.08649226,0.047304396,0.02834466,0.018673502,-0.0019151685,0.07286544,0.001435777,-0.005077719,-0.052038953,0.04158173,-0.0039525502,0.04008508,-0.029476175,-0.07350011,0.03422798,0.14830177,-0.061795525,-0.011488489,0.039544556,0.0017229595,0.043245174,-0.017288394,0.027681243,0.025172023,0.015458949,0.05771642,-0.020416794,-0.01676737,0.0077591483,-0.018391753,0.0013516325,-0.056516867,-0.004098535,-0.020211238,-0.06161364,0.08713626,0.06439454,-0.0025605538,-0.048287474,0.017987855,0.01737487,-3.3249934e-33,0.0663105,-0.094555214,-0.00018193704,-0.10965053,-0.04048893,0.059412777,-0.05395431,0.017183999,0.021296889,0.05848042,0.074418485,-0.022364741,0.10042698,0.048550136,-0.025279803,-0.1016566,-0.0012524992,0.11372531,0.0005834955,0.061681334,-0.043884672,0.07229363,-0.0211362,0.010361302,0.027340798,0.007440454,-0.01375936,0.029179422,-7.6701384e-05,0.03519811,0.05370242,-0.012171408,-0.122075394,0.021257222,-0.014869849,0.102686144,0.0022661334,0.010294487,0.028983463,0.101040065,-0.041453518,0.071541056,0.024902375,0.053401433,0.118145026,-0.0040325867,-0.123294264,0.07280297,-0.042153306,-0.056263577,0.03370594,0.027121285,0.034841225,0.03500688,0.017351534,-0.00047297968,-0.0017436997,-0.025000412,-0.020570064,-0.036605295,-0.027066577,-0.09144499,0.0054175924,0.024478924,-0.051511254,0.043121655,-0.016871592,0.023324609,0.036307193,-0.0068537258,0.048743583,0.017280357,0.019196669,0.089391425,0.014365061,-0.04019752,0.021335624,-0.036533073,0.021945028,-0.040020846,-0.011687945,0.049147088,0.025060559,-0.09508234,-0.005666949,-0.04877209,0.004170132,0.12750503,0.027771352,0.0013886543,0.023125349,0.052676238,-0.06101276,0.083631225,0.057108447,-3.3333414e-08,0.018085778,-0.08653243,0.031263106,0.011407767,0.015911732,0.014924148,0.024769682,-0.030221982,0.018178023,-0.09458114,0.0007011635,0.06323404,-0.05508121,0.046293028,0.0656916,-0.024992293,0.058813516,0.008852997,0.0015994752,0.015256584,0.004278677,0.012885838,-0.046233956,-0.02460414,-0.010066986,-0.08410243,-0.011735323,-0.03525526,-0.012590155,-0.010104262,0.07365125,0.0372168,-0.02388704,-0.012091928,-0.022571003,0.031218663,-0.0058883685,-0.027264643,0.01450758,-0.025381563,-0.045585476,-0.08933514,-0.048855394,-0.019535493,-0.008546753,0.0053619538,0.04851474,0.0031459117,0.009685106,-0.03244785,-0.025921807,-0.01412238,0.03228705,-0.115710706,-0.11783341,-0.0350773,0.008142071,-0.034664333,-0.04639983,-0.112759806,0.02810442,0.009043417,0.19352227,0.0019463095 +1.14.14.162,"A cytochrome P-450 (heme thiolate) plant enzyme that catalyses the 2-hydroxylation of multiple flavanones such as (2S)-naringenin, (2S)-eriodictyol, (2S)-pinocembrin, and (2S)-liquiritigenin. The products are meta-stable and exist in an equilibrium with open forms such as 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione.",384,1.0,-0.04867234,-0.055629022,-0.10071101,0.012893747,0.064204514,0.10159394,-0.06168628,0.07446599,-0.0037034373,-0.023517948,-0.0064469925,-0.04031719,-0.044763036,-0.019005401,-0.050050315,0.033215333,-0.076280214,0.055876113,-0.030008262,-0.030141674,0.041064724,0.003594702,0.057329386,0.053100113,-0.03981084,-0.025156371,0.017242186,0.00294241,-0.045860015,-0.09503859,0.009187685,0.046515167,-0.008201675,-0.018414922,-0.036030583,0.0722154,-0.034350947,-0.03955029,0.01736561,-0.004483068,0.048626114,-0.053778637,-0.05205102,-0.05151812,-0.0023500486,-0.049598422,0.01854341,0.04862468,0.041022684,-0.029210519,-0.07592648,-0.042214878,-0.08514634,0.045675315,0.013833292,-0.038054965,0.016390515,0.010872161,-0.013110544,0.031940673,0.09128994,0.047588505,-0.06643973,0.038079284,-0.022328706,-0.033355467,-0.061000206,0.013147033,-0.0036612572,-0.04611635,-0.038204297,-0.11374673,-0.024752844,-0.011562195,-0.07163857,0.07363846,-0.061094474,0.044433024,-0.00064906833,0.002243781,0.024308443,-0.036422797,0.013240485,0.06499241,0.029380936,-0.009771417,-0.06128707,0.056514937,0.04569196,0.013671239,0.008595618,0.08534348,0.05041877,-0.002936153,-0.07698598,0.06332649,0.059561025,-0.015345178,0.008068156,0.013638293,0.02568437,0.034100454,-0.0019426038,-0.105979264,0.0055934954,-0.0068251,-0.01866247,0.02241188,0.10101089,-0.04252804,-0.028913638,-0.06669954,0.014668472,-0.04806783,-0.04291559,0.11838906,-0.010961529,-0.03556965,-0.030352985,-0.025038462,-0.03026355,-0.029863019,0.05511355,0.00875464,-0.040437657,-0.008948448,-0.07136758,3.285704e-33,0.09739586,-0.0053718844,-0.039842,0.067358695,-0.0023982993,-0.0022306382,-0.08973678,0.011698156,-0.026225055,-0.005197966,-0.07480153,-0.020534892,-0.02734637,0.0010661773,-0.008609275,-0.058228265,-0.050107703,0.022331977,0.10640114,-0.05998072,-0.012500408,-0.063854404,-0.09530119,0.0074412436,-0.0172522,0.076310195,0.05743427,-0.00722986,0.00026469873,0.01156954,0.03669238,-0.11595516,-0.010707799,-0.0005406495,-0.029797686,-0.060787175,-0.06386259,-0.02477348,-0.037366625,0.045518156,-0.09029603,-0.040216733,0.070545144,-0.060130846,0.06946933,-0.050497167,-0.109325625,0.0462613,0.00296613,0.074578755,-0.001508025,-0.023804585,0.10768458,0.09369643,-0.05427331,0.024219,0.0017140595,0.06409362,0.026488425,0.030633863,0.037204973,0.07025404,-0.04422524,0.0012279459,0.004046355,0.09392466,-0.05567818,-0.02210579,0.014733678,0.10103699,-0.00975569,-0.033264164,0.11583297,-0.02212698,0.11230165,-0.0007405714,0.04359104,0.018599143,0.0076347487,0.067831755,-0.020171555,0.0038997913,-0.03656117,0.1165253,-0.034779325,-0.008458366,-0.011022478,-0.013409044,-0.044935286,0.07131673,0.031111004,-0.06790705,0.029208768,0.006435904,0.042046115,-2.3668382e-33,0.05618507,-0.036990248,-0.014521721,-0.050574753,0.011111958,-0.0064949207,0.010258789,-0.06185416,-0.060960226,0.010832168,0.07096912,-0.025418948,0.0021923685,-0.012121908,-0.03754246,-0.013295252,0.07683007,0.016098676,0.02357042,0.018518407,-0.016629055,0.008686535,0.0065910225,0.01905617,0.014487965,0.029492928,0.04727408,-0.033060227,0.013068901,0.11683592,-0.010801607,0.010436319,-0.035317414,0.0093821,-0.04129027,0.065970205,-0.0012818438,-0.006591195,-0.024028663,0.09014133,-0.032638602,3.960846e-05,0.008169906,0.024676222,0.052859236,0.0609698,-0.06630057,-0.020744333,-0.0029457188,-0.027246963,0.05278207,0.08281315,-0.080104895,0.041016348,0.028813398,-0.007914369,0.013373164,0.03381674,-0.020354722,-0.0638729,-0.037538256,-0.07112368,0.025070082,0.03983438,0.04454514,0.09958411,-0.02392341,0.07598325,0.010566324,0.018900136,0.10782203,-0.050083343,0.09747716,0.07593271,-0.0037659714,-0.005204057,0.052088052,-0.057747986,-0.008852798,-0.011735934,0.049160317,-0.011762889,-0.023022402,-0.07935021,-0.05452407,-0.13548708,-0.01155466,0.08276397,0.033420894,0.024207046,0.021250732,0.08432055,-0.02930067,0.010064057,0.10013653,-5.013926e-08,-0.017769936,-0.10385185,0.035360508,0.0065564285,0.06118836,0.01971135,-0.005841601,0.02295926,0.046552684,-0.04403516,0.0016170617,0.09840825,-0.035566803,0.019654619,0.08096866,-0.0246978,0.020707864,0.071204565,-0.011008953,-0.0075556473,-0.06834723,0.053574763,-0.07636995,-0.04943993,0.007080061,-0.08958872,-0.036000814,-0.056466892,0.11951926,0.032747783,0.08363262,0.07458607,-0.025180154,-0.008619128,-0.045663014,-0.029197419,-0.07286787,-0.0021393022,-0.08921455,0.0034266019,-0.054887746,-0.02137938,-0.056930926,0.021805357,0.016820984,-0.020588022,0.07229889,0.05560966,0.0142113585,-0.001628316,-0.00015795857,0.0058504553,0.043637443,-0.099801935,-0.091524,-0.031091189,0.04517503,-0.00798807,-0.044829678,-0.07937024,-0.0146033345,0.039601292,0.19685318,-0.022937967 +1.14.14.163,"The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.",384,1.0,0.028386822,-0.004425603,-0.09635473,0.010593557,0.030045101,0.08346836,-0.06808854,0.046061445,0.06817627,-0.08793833,0.028173015,-0.0012374392,-0.032407466,-0.040776346,-0.037456553,0.019344028,-0.07340375,0.0370573,0.02566771,-0.038339194,0.036440287,0.028704995,0.051243514,0.03258431,0.010143648,0.0733145,-0.04858425,-0.0089348415,0.046625074,-0.07468144,0.07493793,0.015830098,0.013280946,-0.038497522,-0.063648075,0.038134206,-0.06742112,-0.010247411,0.109221,0.043081265,0.07952477,-0.05843749,-0.07462485,0.022907322,-0.018048152,0.021387368,0.00073519174,0.034866985,0.028425125,-0.021020764,-0.025455805,-0.06690524,-0.067027174,0.06527406,-0.015667245,-0.012325103,0.03512686,0.021209467,-0.02745011,0.058752164,-0.011076733,0.062097583,0.02525266,0.040374298,0.059168432,-0.020245222,-0.0032238518,0.007264759,0.07988552,-0.03891499,-0.01097218,-0.08233014,0.008026108,0.016845888,-0.07109184,0.07332511,-0.084499486,0.029930936,-0.018088702,0.0046356902,0.106852666,0.034007333,-0.01568728,0.09747714,-0.014708801,-0.018296888,-0.03860012,0.035807576,0.05528687,0.00051388034,0.06355224,0.001082449,-0.11082873,0.022423755,-0.061388783,-0.012796208,0.0901266,0.036790874,-0.053793475,-0.035583556,0.026673427,0.049242567,-0.11424516,-0.09554657,-0.0073600975,0.0032133276,-0.050842267,-0.07984458,0.011206702,0.021353235,-0.029299391,-0.07062434,-0.050850183,0.02088714,-0.0467262,0.03889083,0.05690894,-0.056384955,-0.07655889,-0.04021885,-0.092372164,0.021079887,0.032462325,0.047070198,-0.0075712698,0.01470198,-0.08273715,1.6222685e-34,0.004726257,0.056328967,-0.033500206,-0.047825307,0.008907706,-0.07405326,0.025816793,0.04904715,-0.012785666,-0.046497498,-0.078444205,-0.058979627,-0.04668518,0.032336026,0.05061727,-0.021585895,-0.033618093,-0.050849408,0.070324615,-0.06822648,-0.054445695,0.009206834,-0.099769704,0.035896804,0.017321026,0.118212745,-0.043000016,-0.013930682,0.021023115,-0.026717411,0.02303876,-0.019409388,-0.04940752,-0.034206193,0.059882436,-0.013259804,-0.03441717,-0.032005705,-0.08189219,0.026908891,-0.014449848,0.02656351,0.08115708,-2.3824414e-05,-0.011646952,-0.026533678,-0.093460746,0.08920157,0.11451541,0.0146254115,0.028898869,-0.01703909,0.014333398,0.018089691,-0.03972831,0.047366984,-0.042680014,-0.0028695865,-0.030438388,0.017895734,-0.0112906555,-0.04051122,0.016942805,0.06849799,0.06006952,0.023844343,-0.06971183,0.0070513324,0.028515961,0.08663978,-0.038069803,-0.0075408234,-0.027836854,0.058815543,0.006140828,0.03940025,-0.0058963858,0.0046358514,0.03687209,-0.034884155,0.022270082,-0.06434639,-0.0009406358,-0.006699343,-0.040531237,0.003910879,0.05642009,0.01849676,-0.022857446,0.07715732,0.006462037,-0.008715452,-0.07103431,-0.019282214,-0.0066095777,-1.7209836e-33,0.08326291,-0.08475417,0.010136893,-0.027119644,-0.0136258155,0.100901306,-0.08769025,0.052336335,-0.008970663,0.11446213,-0.007863824,-0.012886605,0.1028917,0.00069465884,-0.04258558,-0.046514187,0.011515193,0.10459338,-0.009324919,0.018172123,-0.05392651,0.08738572,-0.046066333,0.043785557,0.00030180463,0.010681331,0.052007154,-0.0013374409,0.011982654,0.07522192,0.07221887,-0.0017057175,-0.05859377,-0.008320542,-0.021973975,0.11890567,0.047171343,0.020272372,0.0020189795,0.008046568,-0.006692451,-0.03198855,0.015154912,0.02956077,0.067190275,-0.025581492,-0.07694058,0.054369625,0.015715284,-0.020208234,0.07135931,0.03868461,0.0070611285,0.033302702,-0.012668629,-0.0081094755,-0.03886025,-0.12114843,-0.022332754,-0.12126188,0.023663081,-0.018340504,-0.06684859,-0.081397496,0.006363739,-0.009360852,-0.05225454,0.012776893,0.02171591,0.0068406323,0.08639829,-0.03105181,0.019060543,0.09391771,-0.052956644,-0.03198242,-0.038809992,-0.020200202,0.029917542,-0.04992081,0.004987449,-0.0014748819,0.047357004,-0.033021193,-0.008715547,0.0114285145,0.033781227,0.12849435,0.0032270795,0.012558322,0.028300732,0.004277574,-0.14534047,0.033197597,0.03194301,-2.6699603e-08,0.012748582,-0.05397527,0.06390381,0.026606357,-0.043811835,0.036794238,0.014110968,-0.05235072,-0.01787791,-0.033957902,0.01855876,0.06907739,-0.058507092,0.05828485,-0.0005269333,-0.018479003,0.016426872,0.08038681,-0.027364055,-0.0114356605,-0.09667612,0.010816759,-0.03349749,-0.07898288,0.058500715,-0.039037988,0.0457164,0.0852415,0.018976247,0.024455743,0.06730321,-0.0131563675,-0.026597446,-0.05661,-0.06985032,0.08418075,0.05452394,-0.084769696,0.04957216,-0.028002921,-0.003143361,-0.053124085,-0.0782344,0.021681378,-0.025437428,-0.016394977,0.049858484,-0.026616273,0.01661413,-0.0056026955,0.0015519647,-0.016877325,0.05060495,-0.05851918,-0.08268257,-0.01099076,-0.026287988,-0.005093874,-0.0001192952,-0.13303481,0.019208483,-0.018305859,0.2279804,0.029032633 +1.14.14.164,A cytochrome P-450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.,384,1.0,-0.05134967,0.0061656735,-0.120655224,-0.0008341067,0.10478018,0.08996454,-0.04964161,-0.009987741,0.056033645,0.009781952,0.036514986,-0.01405482,-0.08946006,-0.09081988,-0.01742711,-0.03862229,-0.03125812,0.034320157,-0.06817952,-0.05445918,-0.008945786,0.037279293,0.0235163,0.018145874,-0.008866734,-0.033083573,-0.018616606,0.07934627,-0.029708747,0.03376957,-0.06486315,0.031977247,-0.0024644113,-0.025641847,-0.031902347,0.061167154,-0.027649853,-0.14891024,0.054538257,-0.031748462,0.024415867,0.009466091,-0.0843801,-0.054021604,-0.037189513,-0.056272365,-0.027222713,0.010125247,0.028828993,-0.0018525199,0.0013026132,0.050348535,-0.041630358,-0.03855863,-0.045857515,-0.01484263,0.058494147,0.005522281,-0.007263432,0.025192631,-0.019427782,-0.009646748,-0.040998727,0.029678624,-0.0503895,0.0030832666,-0.03702191,-7.369473e-05,0.023042023,-0.04608957,-0.03272623,-0.07456697,-0.039531633,-0.025532145,-0.10577779,0.14393528,-0.009685367,-0.007987014,-0.015751053,-0.020984191,0.019769898,0.050930187,0.01518719,0.08506589,0.00037474462,0.022954298,-0.03605223,0.04289085,-0.046818223,0.025649428,0.02056515,0.04649032,0.033843424,0.017048962,-0.08816082,0.08698905,0.09114861,-0.023690121,-0.018411674,-0.06557315,-0.009077023,0.08424721,0.035937857,-0.05576729,0.00592209,0.012480211,-0.06071044,0.11463838,0.04820866,-0.03523399,-0.026067724,-0.023354512,-0.020241406,-0.02909664,0.031425696,0.12042223,0.012714392,-0.056898713,-0.03470947,0.01230938,0.036563195,-0.017639626,-0.015282864,0.052336823,-0.013189902,-0.043711822,-0.042430323,-4.5714135e-34,0.076222345,0.07084717,0.011375133,0.063203074,-0.029904293,-0.029013712,-0.094405375,-0.022371553,-0.007875979,-0.004140931,-0.061417125,-0.09026829,0.008710585,-0.08891514,-0.017610582,-0.033399176,-0.03878706,-0.03237844,0.07283057,0.061230175,-0.01790226,0.034868762,-0.021350672,-0.004661104,-0.02234004,0.1259383,-0.059722044,0.018371021,-0.0014355821,-0.019192984,0.029521538,-0.09121857,-0.006259187,-0.04353708,0.06507976,-0.02967217,0.015273272,-0.010642006,-0.07308296,0.04901118,0.038603768,-0.019817334,0.03243412,-0.024779629,0.07726695,-0.016589439,-0.13274719,0.010459701,-0.060710844,0.04160206,-0.0068965736,0.037729174,0.13854721,0.10224128,-0.040536057,-0.041394547,0.019343704,0.04775937,0.0111010745,0.094343945,0.04059901,-0.007888347,-0.016380291,0.1164457,0.053015374,0.022976866,-0.030273046,0.02750803,0.03664334,0.15588184,-0.017962435,-0.039939296,0.052064955,-0.004157438,0.10422327,0.013023813,0.004543444,0.032194257,0.0053082253,0.090701014,-0.0064052334,-0.0067584845,-0.0393598,-0.031739045,-0.046589274,0.016333144,-0.038122244,0.028909456,0.04302195,-0.03934154,0.07913265,-0.017668437,0.049202405,-0.024726493,-0.08640623,-1.6548079e-33,0.033285514,-0.030251492,0.0053309263,-0.07061495,-0.116310135,0.060706332,-0.04513622,-0.12122123,-0.0778809,0.02021417,0.0800458,0.00047912495,-0.008990433,-0.042645782,-0.049677763,-0.005654138,0.030045291,0.04104833,0.031323873,0.08732249,-0.0052927877,-0.03491741,0.079127885,-0.02334462,0.042136658,0.026821766,0.013627741,-0.08748959,0.005200002,0.010596991,0.025064457,-0.027106415,-0.036398582,-0.04761136,0.00012711306,-0.040302005,0.0073227133,0.017236117,0.04055006,0.041378114,-0.02656563,-0.017037384,0.04241365,0.040971104,0.051580265,0.013054621,-0.108122915,0.0032330924,-0.04749388,0.059598874,0.020188898,0.043877203,-0.063337296,0.026425371,0.024581559,-0.036489613,0.08428712,0.019626733,0.01216981,0.032543845,-0.03720267,-0.014295486,0.013204183,0.06400865,0.016058274,0.1347876,0.0080533745,0.09102348,0.01135929,0.012872402,0.005422941,-0.010488747,0.0858075,0.029160086,-0.029934233,0.0026164663,0.05680338,0.019767843,-0.030994771,0.020888923,-0.03594353,-0.024690188,-0.043462593,-0.02998151,-0.050123524,-0.106956,-0.06150635,0.03354807,0.04907905,-0.04034915,-0.04789016,-0.0010857693,-0.000572856,-0.018812034,0.040223494,-2.5104749e-08,-0.05769468,-0.042324815,0.015830152,-0.045367554,0.06474569,0.027310723,-0.05029983,-0.070088014,0.041497078,0.04405209,0.008959499,0.047520846,-0.01323224,-0.03551012,-0.0050504035,-0.029251533,0.052611686,0.038828764,0.063652955,0.017127376,-0.07435117,0.050517865,-0.0583402,-0.030895438,0.046299245,-0.13812189,-0.045329295,-0.030785069,0.090561524,0.04496086,0.0074330806,0.032129236,-0.0028596856,-0.0005553364,0.03595364,-0.028208641,-0.0048942287,-0.03466544,-0.06417385,0.0077383467,-0.10255264,-0.0030996047,-0.07247774,-0.036177777,-0.0048938044,-0.0042556548,0.08714217,0.072468996,-0.0020183004,-0.0010425544,-0.019821728,-0.032346793,0.08753537,-0.13578552,-0.09408597,0.023266476,0.09749309,-0.07651894,0.015057637,-0.011342095,-0.025913794,0.0034701668,0.07400198,-0.011566323 +1.14.14.165,A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin [1].,384,0.99999994,-0.08576897,0.056952767,-0.022283541,-0.03265389,0.094418496,0.06810988,0.00018421211,0.10538159,0.0036546742,0.009181533,0.04806898,-0.05707891,-0.03783017,-0.01919427,-0.045915186,0.052980736,-0.07371395,0.03892773,-0.009489988,-0.07423224,0.0033543909,0.07455765,-0.014062035,0.037705824,0.00176165,0.0079491045,-0.0032590083,0.069264136,-0.029211797,-0.024820099,-0.08545521,0.0064507974,0.056175124,-0.009257354,-0.024052612,0.12330937,-0.021663915,-0.10460776,0.032219194,-0.06687849,0.08598317,-0.034533978,-0.08033432,0.0181359,-0.0932797,-0.031126922,-0.00820907,0.022792362,0.01522694,-0.041755635,-0.01973416,-0.01187393,-0.0573244,0.025238086,-0.021194845,-0.05342724,0.03449031,-0.022715935,0.0015357262,-0.014671835,-0.02638562,0.018188175,0.0005789791,0.035251632,0.008420987,-0.045034762,-0.082103394,0.013677392,-0.0074570156,-0.06457617,-0.015239383,-0.057886098,-0.011905076,0.012442198,-0.10509093,0.10758015,-0.014957144,0.012837456,-0.02610758,0.007437276,0.07372062,0.060956378,0.05103968,0.12367998,0.02916347,-0.029641235,-0.069959916,0.06269049,-0.03895318,-0.0004904525,0.03666329,0.07051906,0.023013067,0.001743119,-0.053404048,0.068321735,0.06600928,-0.06507871,-0.0033918156,-0.010456332,0.0509641,0.044349108,-0.01931672,-0.119067945,-0.0011429169,-0.02450605,-0.021964882,0.026325291,0.03227197,-0.08444428,-0.07150885,-0.06614576,-0.032333605,-0.016809888,0.008547241,0.068981215,-0.0080835875,-0.023337722,-0.020012487,-0.064075,-0.03374812,-0.03272617,-0.021045122,0.0021003343,-0.056280587,-0.04271421,-0.1120998,3.272293e-33,0.0911295,0.07899707,-0.047726296,0.0063488316,0.0007172719,-0.037789024,-0.01808355,0.08567883,-0.035871662,0.0194851,-0.091167234,-0.07390714,0.01738466,-0.0618423,-0.03790712,-0.01908636,-0.10827358,0.041035388,0.03718895,0.027296199,-0.057843182,-0.056904476,-0.06356275,0.0002581335,-0.028908696,0.11328844,-0.012854076,-0.05811609,-0.0071220077,-0.023844806,-0.06438099,-0.040193755,-0.046801005,-0.029324904,0.049542133,-0.06082471,-0.0070215724,-0.02606662,-0.07517717,0.04863831,-0.08587206,-0.00517335,0.01143625,-0.07989865,0.09766053,-0.006351136,-0.13471195,0.0002752218,0.010528328,0.06284339,0.077111274,-0.058422085,0.11996266,0.023005385,-0.038877666,0.009032727,-0.0015504685,0.063852616,-0.033145133,0.050750412,0.07351485,0.024558438,-0.029595334,0.04981595,-0.0009403972,0.07214747,-0.04296857,-0.06684929,-0.021305522,0.14530219,-0.03787949,-0.024503881,0.06736329,-0.036115807,0.06937107,-0.0052433116,0.008578976,0.08073434,0.033266068,0.074778385,0.03908507,-0.03127984,-0.010231695,-0.01978726,-0.036987342,-0.021522965,0.060127914,0.006591935,-0.020427931,0.062334705,0.078740515,-0.08948432,-0.0013230767,0.009663921,-0.05120954,-3.322287e-33,0.070586935,-0.039773125,0.026233507,-0.096951656,-0.04140919,0.06047472,-0.027637824,-0.021580858,-0.017395964,0.025919525,0.10814683,-0.0074555497,0.025262319,0.008178046,-0.0036919978,-0.00023085119,0.029948693,0.016508691,-0.036335137,0.0551823,-1.3749154e-05,-0.0024154652,0.007125465,0.018346258,0.044799503,0.017883986,0.038318302,0.017298413,0.080985755,-0.009938973,-0.058503643,0.04494963,-0.040804867,-0.0047672377,-0.007901094,0.016208608,-0.00346087,0.02589902,0.03769851,0.035313275,-0.0034381873,0.045662783,0.020893972,0.09382637,0.02763737,0.096298195,-0.054596685,-0.026647508,-0.0049982476,0.011522677,0.029896691,0.036051128,-0.06346812,0.0689945,-0.05206157,-0.01777246,0.01657139,0.01556315,-0.018359948,-0.0021583196,-0.004427744,-0.09192779,0.009243662,0.07671963,0.00456986,0.05447134,-0.016569266,0.060167708,-0.017215129,0.014853842,0.08128962,-0.008417246,0.06898894,0.066685334,-0.038332164,-0.022603514,0.05491473,-0.037547056,-0.00807971,0.023640797,0.039297525,0.032278195,-0.048050243,-0.0658137,-0.015292792,-0.053820245,-0.011397156,0.1354189,0.022689598,-0.04039153,-0.0025030822,0.074631356,-0.04893556,0.044569965,0.07085713,-3.5310997e-08,-0.03687852,-0.09209157,0.037282698,-0.04661886,0.017396959,0.054665815,0.033535667,-0.005726704,0.06341006,-0.0042724307,0.017554086,0.033491798,-0.016375113,-0.029621482,0.00841655,-0.017577516,0.01184327,0.039070617,0.03704962,0.04251249,-0.02655393,0.007266483,-0.06729367,-0.020810802,0.040816274,-0.11203635,0.006577477,-0.02116158,0.077709004,-0.038380306,-0.006288839,0.05173785,-0.02209179,-0.0036898886,-0.017429905,0.07392875,-0.023349686,-0.07155935,-0.0051935012,-0.06754512,-0.07140492,-0.01657271,-0.089546815,-0.03649308,0.0012044869,-0.0026386215,0.08409059,0.043726463,0.018563172,-0.005671917,-0.0131322155,0.008963643,0.04774199,-0.13916917,-0.08106544,0.028575791,0.09024486,-0.014166106,-0.029980475,-0.08374761,-0.013229894,-0.021773268,0.17844437,-0.014865284 +1.14.19.75,"The enzyme, characterized from the plant Arabidopsis thaliana, acts on both 24:0 and 26:0 fatty acids, introducing a cis double bond at a position 9 carbons from the methyl end. These very-long-chain fatty acids are found as a minor component of seed lipids, but also in the membrane phosphatidylethanolamine and phosphatidylserine, in sphingolipids, as precursors and components of cuticular and epicuticular waxes, and in suberin.",384,1.0,-0.062496852,-0.042187005,-0.09632763,0.01098999,0.014524826,0.085843824,-0.08311661,-0.0005807554,0.04581893,-0.005688081,0.12280811,-0.07518054,-0.115778066,-0.05162177,0.05345204,-0.0068130554,-0.06022645,-0.0115144625,-0.0590724,-0.06736111,0.11137319,0.044545047,-0.022898182,0.0046073953,-0.013471786,-0.03906655,0.0011583702,-0.06809499,0.0041446122,-0.025675869,0.0361753,-0.013208953,0.08561301,-0.03232671,0.00093065295,0.07463077,0.030403214,-0.08916287,0.11255844,0.0019883502,0.064103276,-0.056854613,-0.02544868,0.006296649,-0.042513914,-0.058656108,-0.012529665,0.058667544,0.034860414,-0.031307675,-0.022752618,-0.09681528,-0.035601225,-0.0044312244,-0.026566705,0.04848225,-0.0416162,0.05628336,-0.006568776,0.08750913,0.056188148,0.0014414992,0.04816625,0.022928486,-0.05402314,-0.06835821,0.0008711616,-0.07211272,0.072797954,-0.040087126,-0.043996274,-0.04751123,-0.01688106,-0.01826612,-0.018000465,0.07967136,-0.049442858,0.0035327813,-0.012410767,-0.06916847,0.013836015,-0.036030535,0.015340546,0.08120677,-0.017936764,-0.040595103,-0.02863016,0.044885498,-0.00055829977,0.079840556,0.05137673,-0.035217416,0.011165517,0.06120471,-0.04031411,0.06067038,0.029122148,-0.018531837,-0.053074546,-0.025114084,0.012009896,0.009943353,-0.07610908,-0.06388382,-0.02362591,0.04583593,-0.080502726,-0.045058284,-0.075297475,0.02017751,0.034926005,0.010010211,0.016789556,0.0038248,0.021424608,-0.04368673,-0.010361575,-0.059252556,-0.0042365254,-0.019635998,-0.08478022,-0.04968353,0.0032951592,-0.0013330987,-0.06383226,0.008581529,-0.12345834,3.8968126e-33,0.03062772,0.017861044,-0.008954956,-0.044441115,-0.057061903,-0.04666418,-0.05215188,0.033333257,-0.0953672,-0.021123547,-0.04316875,-0.0942962,0.033948794,0.042242818,-0.06149778,-0.0012080364,0.0073840586,0.047204066,0.11006556,-0.003446808,-0.08371504,0.043119673,-0.020906663,-0.104625374,0.039910987,0.034433976,-0.06021242,-0.121815264,0.07280634,-0.009179129,-0.015228771,-0.05355362,-0.047283243,0.057472065,0.10305183,0.033985656,-0.022705102,-0.00068271457,-0.099639654,0.009965742,-0.0066913147,0.029073277,0.00046360094,-0.041970674,0.0070339045,0.021184364,-0.0661171,0.04858183,0.11453567,0.051981475,-0.018925337,0.051195852,0.11272881,0.039703105,-0.036097806,-0.036982518,0.019286595,0.014615327,-0.062245738,-0.0070675034,-0.027490815,0.05242893,-0.059586015,0.017879188,-5.425857e-05,0.056279242,-0.1592474,-0.051306117,-0.030659093,0.057967406,0.010413384,-0.0036951934,0.060693894,0.0048366906,0.0036832453,-0.011128319,-0.021686222,0.021547444,-0.06522528,0.099544145,0.05170184,-0.0008295845,0.021326685,-0.051480766,-0.08250687,0.02579764,-0.031089023,0.01213452,0.052764222,0.011005862,-0.01937827,-0.072987035,-0.032615654,0.06501532,0.007651431,-4.929288e-33,0.048073225,-0.037471257,0.07721911,-0.079773754,0.029198773,0.04099363,0.018071927,-0.018729197,0.034845892,0.015894366,0.082387,0.0248503,-0.019203305,-0.02968475,0.007877038,0.03258921,-0.012936255,0.05136464,0.028241144,-0.03484643,-0.03749019,0.038572483,-0.046888873,0.14732248,0.03967671,0.028866809,0.041951343,0.059089836,-0.014070999,0.011816039,0.045567114,-0.02470944,-0.058305655,-0.019087981,-0.034767214,0.01488673,-0.10246109,-0.0072181616,0.021943139,0.021236572,-0.03101913,0.011933714,0.054775596,0.04454466,0.04433312,0.014171653,-0.046631306,0.039994527,-0.06231075,-0.044001732,-0.026061825,0.029536504,0.008316125,0.10912175,0.07292498,0.03759818,-0.03338701,0.13108025,0.021175262,-0.097242266,-0.024444932,-0.07164524,-0.06198771,0.008081563,0.029885001,0.037516166,-0.009215232,-0.045042083,-0.015208097,0.020120263,0.053931475,0.07339172,-0.033017818,0.041914128,-0.012391951,-0.061399296,-0.020557897,-0.10078619,-0.059268706,0.0371877,0.03990241,0.035384227,0.0053193425,-0.05519687,0.07925399,0.0005670983,-0.004972351,0.07369673,0.0014440628,0.05737481,0.011313447,0.008185999,-0.08802314,0.03743226,0.081949085,-4.5918295e-08,0.020880422,-0.058905896,0.008031025,-0.08135066,-0.04602576,0.01578606,0.053307645,0.003810048,0.009942993,-0.03234591,-0.019863812,0.05513041,0.028448988,0.04721573,0.049387474,-0.043725822,-0.014932672,0.050091386,0.004294152,-0.024109334,-0.017470585,-0.026550762,-0.0919797,0.026068412,0.00057057873,-0.033139758,0.0414122,0.04685212,-0.002534568,0.09549277,0.058350656,0.0016049289,0.041330025,-0.016120816,0.04865506,0.03320742,0.03378565,-0.010584113,-0.0778475,0.08500203,0.016824601,-0.020738704,-0.06028634,0.0018253478,0.011717773,-0.014168358,-0.023145618,0.10729159,0.0144891525,0.07673281,0.0044654487,0.03125344,-0.03190399,-0.027041567,-0.055362687,-0.075402714,-0.00985491,-0.0018755685,-0.032254577,0.039932214,0.0436434,-0.025437094,0.18807893,-0.04189273 +2.1.1.350,"The enzyme, found in a wide range of bacteria and archaea, is a radical SAM (AdoMet) enzyme that utilizes two molecules of S-adenosyl-L-methionine, one as the methyl group donor, and one for the creation of a 5'-deoxyadenosine radical that drives the reaction forward.",384,0.99999994,-0.097010255,-0.08895288,-0.10088405,0.04913462,0.056647822,0.016836574,-0.09186193,0.033672627,0.045395102,0.05591441,0.021404339,0.009345962,-0.0756183,0.06296826,-0.0118313115,0.11075245,-0.10891331,0.008666214,0.04880661,-0.027861355,0.048359253,0.060982037,-0.046212215,-0.011322499,0.07919635,0.026253866,0.071785815,-0.055861145,-0.054973967,-0.032349262,0.08074958,-0.064353555,0.08197229,-0.005219749,-0.0072209244,0.12509836,-0.018025106,-0.027987838,0.06111244,0.0010332284,0.015819615,0.042443894,0.030927658,-0.057396844,-0.032686837,-0.04011415,-0.009442058,0.0055359285,0.06996376,-0.03444364,-0.07147229,-0.052381143,-0.054148525,-0.014731926,0.030409865,0.03167607,0.0067861206,-0.071535826,-0.022516279,-0.037397873,0.09489551,-0.004856186,-0.011403945,-0.037725586,-0.010538473,-0.027440974,0.060336918,-0.06956433,0.06486662,-0.0519139,-0.03704982,-0.049599852,-0.022662139,0.030373676,-0.033696365,-0.049513996,-0.030106727,-0.06394863,0.06251372,-0.013390105,0.055499926,-0.022256466,-0.004394296,0.04846399,0.054900847,0.04840868,0.02934788,0.038518623,0.0679401,-0.004321472,-0.032869913,-0.026193516,-0.050362606,-0.11762985,-0.024847135,-0.016430471,-0.03045328,0.044513315,-0.022070568,-0.002841434,-0.024436645,0.09745246,-0.040635902,-0.1060579,-0.05363268,-0.018239727,0.004253935,0.077252,0.03443026,0.025102876,0.030902252,0.046668343,0.0676716,0.010978578,0.0077636912,0.055950217,0.03131967,-0.081822045,-0.08817737,0.04190653,-0.013988787,0.005614149,0.052792285,0.052223288,-0.0070470846,0.08028782,-0.111406684,-6.682986e-34,0.08737003,0.045170695,0.044568636,-0.014732474,0.011310235,-0.0036918444,-0.08529486,0.004540145,0.010293097,-0.02870874,-0.064418145,-0.07146337,0.08972362,-0.011208953,-0.037831042,-0.020391041,-0.033438817,-0.017041033,0.015763905,-0.012856831,-0.099445835,0.031728454,-0.08147425,0.018983189,0.0141497,0.025513,0.051481247,-0.0069760974,0.08925603,0.016348518,-0.037933927,-0.05545922,-0.13778202,0.026283298,0.07113293,0.028604476,-0.06914952,-0.059380636,0.025703818,0.037570752,0.0415446,0.005022712,0.033580575,0.04013879,0.03442614,-0.0052436423,-0.033026304,0.08734451,0.034973487,0.07736921,0.014584314,-0.017317072,0.06795749,-0.017977413,-0.082441926,-0.010169998,0.0063727144,0.02508502,0.03888192,0.092093125,0.005415309,-0.013043449,-0.052678365,0.04930499,-0.029731054,-0.008965193,-0.04695333,-0.052646022,-0.002196989,0.11528326,0.0056037405,-0.021057194,0.07642987,0.06567231,-0.052622568,-0.030232893,0.023667755,0.040600967,0.05315799,-0.027240522,-0.09347047,-0.053631835,-0.0034375414,-0.014275857,-0.047199786,-0.005379852,-0.040241327,-0.05936489,-0.0411952,0.0052112094,0.0005955518,-0.07653366,-0.064282544,0.03266951,0.0026660112,-1.2501339e-33,0.024728766,-0.11624104,0.0023015032,-0.074483246,-0.053896785,0.06784076,-0.007814068,0.022986814,0.013838867,-0.05132915,0.08306568,-0.008314877,0.048500456,-0.06021719,0.10583892,-0.021949325,0.041477237,0.0020455057,0.021120751,-0.0077611487,0.071688674,0.097393565,0.01998364,-0.022653675,0.07918676,-0.015351061,-0.000946183,0.07640339,0.030094605,0.047078207,0.035390638,0.007487575,-0.021711834,-0.035710443,-0.06026108,0.089677095,-0.0059024114,-0.03422955,-0.026532292,-0.0020188743,0.0004591788,0.027602233,0.006455918,0.16024697,0.034979038,0.08238849,-0.056221787,0.015250623,0.010425642,-0.11924344,0.01026448,-0.057659224,0.030167868,-0.05411527,-0.038709205,0.057598867,-0.017675871,0.021708151,-0.058343668,-0.047103524,-0.04195501,-0.04416035,0.0653566,-0.00025886914,-0.0286241,0.02522985,0.05163581,0.0047755744,-0.024535432,-0.05772259,0.0024651242,0.026853463,0.0056558037,0.10380952,-0.047089174,-0.027952809,-0.094842225,-0.027956018,0.037947413,-0.044706512,0.009819998,-0.008750479,-0.016537815,-0.04108621,0.0090991035,-0.06237422,0.0422784,0.1152612,-0.014159524,0.023065982,-0.095897816,0.033777844,-0.0799253,0.0415921,0.027739858,-3.8570217e-08,0.04256653,-0.04394792,0.076931745,-0.039401468,0.009282558,0.08083005,0.010680814,0.03016958,-0.006566375,-0.03536225,-0.044016857,0.10432774,-0.05027335,0.057091046,0.0017010707,0.029415945,-0.050184246,0.00044965916,-0.044542007,-0.018397776,-0.031656485,0.0011113156,-0.017219434,0.02499873,-0.029009053,0.010637617,0.046629395,0.05002098,-0.026619134,-0.027570134,0.034965526,0.01696994,-0.04986855,0.014695343,-0.1438544,0.005480001,-0.021051489,-0.021665711,-0.0058597224,0.05633295,0.01728795,-0.028288089,-0.10399034,0.056770913,-0.03526149,0.034062874,-0.019465439,0.0028289836,-0.020028356,0.008875575,0.0484814,-0.029363602,-0.013385312,-0.017047843,-0.10402698,-0.020528235,-0.028496554,-0.07854852,0.009362351,-0.0052661304,0.043476116,0.0054160617,0.148224,0.021840667 +2.3.1.274,"The enzyme, found in bacteria, catalyses the synthesis of fatty acyl-phosphate from acyl-[acyl-carrier protein], a step in the most widely distributed bacterial pathway for the initiation of phospholipid formation. While the activity is modestly enhanced by Mg2+, the enzyme does not require a divalent cation.",384,0.99999994,-0.12752064,-0.047525637,-0.09008554,0.067896046,-0.022492997,0.025444696,-0.022240056,0.02141716,-0.015067685,0.0057103373,0.07784458,-0.018725153,-0.00071185443,0.056993835,0.028055256,0.0007285803,-0.03487648,0.0070606014,-0.004924703,-0.06508105,0.06047438,0.0019756423,-0.058545712,-0.021055961,0.011701499,-0.007815953,0.069538906,-0.08096902,-0.006682862,-0.021575019,-0.0104215015,-0.04803569,0.082320824,-0.074558094,0.060209766,0.055938162,-0.00091176585,-0.009126335,0.06853462,-0.033453744,0.02575303,-0.05645629,0.05678929,0.016287351,-0.0041209282,-0.05791062,0.023326501,0.066559896,0.05302869,-0.037271027,-0.10663156,0.0067201713,-0.06560308,-0.0061128414,-0.029051207,0.02920354,-0.08937384,-0.05437342,-0.061078,-0.05211776,-0.028411783,0.0018706819,-0.008338577,0.06904397,-0.03521166,-0.10221061,0.013869054,-0.05980229,0.099452466,0.032417297,0.007768477,-0.07753818,0.0005822832,-0.023526628,0.034146845,0.029616954,0.012703391,-0.06143327,0.050223242,0.022418948,0.061762974,-0.03580924,0.05157133,0.060377464,0.04426208,-0.05568264,0.057443336,0.013600458,0.009249855,0.060038675,0.062005103,0.0069433404,0.016849928,0.0070144567,-0.098725304,0.038147938,-0.021603497,-0.033385225,0.04510486,-0.003482406,-0.0043206615,0.06791766,-0.0102597,-0.038270015,-0.0256196,-0.015708718,-0.02593273,0.038840294,-0.0018299128,0.03475574,0.043271255,-0.02350359,0.026096428,-0.0050131353,0.019158859,0.08386265,-0.028418113,-0.08045208,-0.041636728,0.005036887,-0.032412633,-0.061429817,-0.04445041,0.04335636,-0.053132143,0.016501606,-0.12072082,1.9433197e-35,-0.011503597,0.037145093,0.0037415228,-0.023622222,0.006070305,-0.039382648,-0.07305039,-0.0026553292,-0.040777486,-0.03998172,-0.020738207,-0.07366517,0.022616552,0.06906442,-0.023588689,-0.06779288,-0.00348827,0.08007228,0.109078236,0.060983468,-0.04084023,0.05543331,0.084996946,-0.06201208,0.033652972,0.09805099,-0.02539183,-0.041562345,0.0163215,0.03723772,0.040845722,-0.11860129,-0.06994335,0.036429655,0.042077158,-0.029493794,-0.07522781,-0.05653171,-0.03382974,0.044206064,-0.04088432,0.007945517,-0.059183232,-0.011706247,0.013520284,-0.012314574,-0.09598108,0.08654544,0.023558384,0.040468443,0.05624732,0.027521191,0.07331958,0.06158824,-0.049657613,0.03035847,-0.07565239,-0.0077208746,0.039264023,-0.054864842,0.02411958,0.06774672,-0.06906137,0.027211584,0.027380764,0.0027540887,-0.0017788376,-0.06362958,-0.012756112,0.15150157,0.03843032,-0.013788536,0.012815147,0.03129722,0.010889752,-0.005440413,0.0064404984,0.054985855,0.0010481421,0.011191176,0.02542553,-0.001509396,0.058120385,-0.022757396,-0.06137132,-0.016606519,-0.04124463,0.005541693,0.014566886,0.005430526,-0.0032610367,-0.015874585,-0.03135579,0.062385768,-0.0031615829,-1.9997008e-33,0.13002497,-0.1044627,0.062012125,-0.13784228,-0.12208531,0.031437345,0.030782655,-0.033875152,0.09053856,0.03150441,0.018824762,0.04232906,0.04852634,-0.06412996,0.017330883,0.0020706912,0.008344942,0.023314353,0.024136987,-0.030250184,-0.011483817,0.031505432,-0.010708899,0.095779926,0.025225816,0.0076685273,-0.044968892,0.06576469,-0.013631586,0.059889346,0.027778586,-0.0058478056,-0.029409504,-0.091589086,-0.096981764,0.09199175,-0.05427056,0.045732036,0.031084612,0.09594384,0.060686063,0.055045877,0.075639986,-0.038779967,0.04449984,-0.008554882,-0.012100773,0.057852447,0.006819985,-0.15805162,0.0012426284,0.009024005,0.039477263,-0.030295772,0.02944732,0.121735886,-0.021969764,0.027133262,0.038896736,-0.11829604,-0.04601714,-0.11691761,0.038505174,-0.032397687,0.00031488933,0.08079035,0.02576269,-0.041426167,-0.006972504,0.030740066,0.008424918,0.11981589,-0.03805977,0.05268425,-0.0055867834,0.04043668,-0.058831252,-0.08916826,-2.2121609e-05,-0.006754037,0.0056141843,0.0038137485,-0.000249267,-0.07393831,-0.020596104,-0.042392895,-0.008885615,0.04472915,0.046463754,0.015572346,-0.03809398,-0.039355256,-0.056886367,0.002939285,0.02653751,-3.5023e-08,0.007630204,-0.066888265,0.04258914,-0.038705885,-0.020802999,0.06656926,-0.014889634,-0.0782179,0.07183983,-0.0857693,-0.036088254,0.033766463,0.034954935,0.03113435,-0.0042162077,0.04006829,-0.061308324,-0.012384969,-0.025592875,-0.08832675,-0.027788887,0.003438824,-0.051011812,0.0633806,0.021186821,0.010808031,0.028644707,-0.030830787,-0.07459801,0.009630338,-0.0013120832,-0.010328765,-0.0036053162,0.025517331,0.03418531,-0.016675968,0.0010232966,-0.08726778,-0.069661684,-0.0042786165,0.03473271,0.051406503,-0.0018694126,0.011663701,-0.012748698,0.03698182,-0.011189709,0.052943952,-0.07142281,-5.427237e-05,0.05330596,0.022205714,-0.086738534,-0.035787147,-0.06390371,-0.04013514,-0.023654154,-0.08849856,-0.034185473,-0.033692278,0.03174752,0.0584129,0.18132663,-0.026344629 +2.3.1.275,"The enzyme, found in bacteria, catalyses a step in the most widely distributed bacterial pathway for the initiation of phospholipid formation. The enzyme is membrane-bound.",384,1.0,-0.106712215,-0.027691921,-0.112766124,0.012894321,0.003307712,0.06457432,-0.057850983,0.07180455,0.066771865,0.016604265,0.022626072,-0.023416828,-0.060614325,0.10268489,0.0054860907,0.015271405,-0.097343996,-0.05666438,-0.021327762,-0.05865019,0.05752036,0.013625121,-0.05924128,-0.010095857,-0.014143844,0.04347896,0.09558913,-0.09308373,0.0168845,-0.030610159,-0.03134329,-0.03147382,0.08906599,-0.061913956,0.03424127,0.080515295,-0.015368326,-0.03148471,0.08560476,-0.011119171,0.02526607,-0.009949663,-0.01058277,-0.019219302,-0.010755514,0.04941735,0.018611563,0.103569865,0.03575335,-0.056444153,-0.07608746,-0.029488252,-0.048636444,0.03856515,-0.01925664,0.03354277,-0.049406923,-0.05759364,-0.025930274,-0.026215252,-0.012355976,0.001450816,0.043666206,0.08856869,-0.015334876,-0.08514423,0.037448563,-0.05267913,0.058594022,0.038508434,-0.021283127,-0.017915858,-0.025666934,0.027920092,0.07806873,-0.016829014,0.039219942,-0.01623184,0.031869803,-0.026768079,0.06806655,-0.029884558,-0.023177708,0.10205728,0.00072354416,-0.013112497,0.036754053,-0.044716522,0.074034445,0.05212139,-0.0005911173,-0.04528384,-0.0151129,-0.02450632,-0.08056762,0.013854548,-0.0046960125,-0.012537842,0.06986354,-0.037490975,-6.4758504e-05,0.01772168,-0.02014658,-0.0378439,0.01070715,-0.03494229,0.050870646,0.035220455,-0.018130023,0.04364569,0.076253116,-0.0056947507,0.099825025,-0.008069175,0.023451319,0.03879865,0.032445762,-0.038867332,-0.063175514,0.04333817,-0.033602487,-0.070513174,-0.030024618,0.010182296,-0.091444656,0.058742717,-0.14256603,-2.0452443e-33,0.011224983,-0.0255285,0.0033171526,-0.024634229,-0.034019034,-0.050558023,-0.052000266,-0.02750701,-0.07193317,-0.028855652,-0.04179714,-0.07922361,0.012316835,0.067833215,-0.020216202,0.0032872327,0.014639544,0.048912983,0.029914534,0.026339259,-0.012730365,-0.04117306,0.0421849,-0.06727925,0.05080297,0.057326835,-0.046012517,-0.036182582,0.048627995,0.00071057817,0.049665604,-0.10535217,-0.091046356,0.029753108,0.065794386,0.0049341926,-0.041273367,-0.034720458,-0.021405505,0.011934349,-0.043251853,0.0049846633,-0.025550745,-0.041695673,0.03232178,-0.03196769,-0.12689574,0.104480915,0.071405165,-0.0032518613,0.011454972,-0.002239312,0.10602605,-0.0029953646,0.0061986325,0.0017182992,-0.012388549,-0.01239966,-0.008178502,0.021121074,-0.0038755322,0.08693554,-0.112694375,0.07274558,0.06841616,0.054599855,0.010272324,-0.051192988,-0.0048026885,0.0901823,-0.024248125,-0.0009242272,0.0071923696,0.017998476,-0.017914662,-0.01811232,0.018037438,0.015495395,0.03364281,0.010032865,0.052906886,-0.035328634,0.03344866,0.0025955865,-0.07216156,0.006771675,-0.023810374,-0.050779022,-0.058702826,0.05802606,0.0066579017,-0.050531097,-0.023814602,0.05661098,-0.034493107,-6.6514443e-34,0.10652297,-0.1057567,0.053734437,-0.119510025,-0.03839161,0.08128336,-0.026094621,-0.030803366,0.06812977,0.015750166,-0.022511132,0.052298624,0.020530812,0.011820498,-0.004419922,0.0337897,0.02512253,0.01708996,0.027902326,-0.022142425,-0.02451272,0.029841173,-0.0141960615,0.07176364,0.02406671,-0.034941286,-0.06643725,0.098307624,-0.06990344,0.03737547,-0.050188806,-0.06575429,-0.06223407,-0.05718623,-0.074614264,0.07150198,-0.040621225,-0.0075001004,0.09345548,0.03335077,0.023388362,0.030429132,0.051685937,-0.059894904,0.021178985,0.052042328,-0.047971766,0.07319471,-0.060155157,-0.03138285,-0.024573034,0.027976599,0.042893324,0.04033987,-0.01658536,0.093268245,-0.03804382,0.059922855,0.00886123,-0.069093384,-0.06690881,-0.12746786,0.030950166,0.033334464,0.0073771463,0.0442555,-0.02022826,0.014884594,0.023917815,-0.049032316,0.020997308,0.09418999,-0.032207858,0.0174473,-0.04171444,0.02933246,-0.085226625,-0.11674293,0.05489798,0.028471453,0.022652267,0.016491089,-0.0033854374,-0.08491231,0.036768466,-0.022524804,0.04665983,0.030621773,0.052317582,0.03681279,-0.023842566,-0.06637691,-0.06703407,-0.016867874,0.035389163,-2.6730572e-08,0.03510987,-0.06680959,0.058029883,-0.04905923,0.04205211,0.07486051,0.060324736,-0.013794851,0.03371096,-0.025058882,-0.042031948,0.0455368,0.008850457,0.0052997735,0.045974426,0.03987342,-0.096456766,-0.015127813,-0.03713648,-0.0836544,0.014827069,-0.0048455046,-0.052245457,0.054197125,0.051171064,-0.047515463,0.034561064,-0.035649445,-0.08883425,0.016857825,-0.018909967,0.014203151,-0.01345566,-0.0037321488,-0.0068502394,-0.0065592024,-0.042933084,-0.064791285,-0.047245912,0.05709139,0.07408018,0.067271486,-0.06450611,-0.022304848,-0.03570166,0.10036358,-0.0119967135,0.069132306,-0.043553684,-0.012436175,0.03943994,0.010892501,-0.014587398,-0.0039670565,-0.10973919,-0.020417856,-0.020370742,-0.0562994,-0.013058645,0.0014048192,0.027148057,0.10282421,0.21878536,9.005406e-05 +2.3.1.276,"The enzyme, characterized from the archaeon Sulfolobus tokodaii, is also active toward alpha-D-glucosamine 1-phosphate (cf. EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase). In addition, that enzyme contains a second domain that catalyses the activities of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase, EC 2.7.7.24, glucose-1-phosphate thymidylyltransferase, and EC 2.7.7.83, UDP-N-acetylgalactosamine diphosphorylase.",384,1.0,-0.06564726,-0.059318244,-0.1254642,-0.075297825,0.02334833,0.013837717,-0.044776533,-0.006386551,0.015546359,0.05973784,-0.030566292,0.011159775,-0.05482895,0.0425998,-0.087488346,0.049408305,-0.056435324,-0.051429342,0.050449744,-0.063643076,0.081079684,0.029639933,-0.028769089,-0.0144953495,0.039829053,0.007526015,0.027156271,-0.037905265,-0.07396615,-0.085974924,-0.057008002,-0.048549805,0.02542058,-0.006784738,0.095537834,0.15109883,-0.06248352,-0.04390793,-0.0009834411,-0.016820563,0.05184114,-0.0261922,-0.009835049,-0.08624344,-0.08016315,-0.00798494,-0.040087733,0.029581975,0.06063357,0.0010473807,-0.015105208,-0.040101092,0.0063765324,0.038551178,0.06255271,0.02156809,-0.0631542,0.052319482,-0.03464242,0.022667607,0.010646594,0.034799565,0.008024928,-0.02583985,0.0068518515,-0.06442472,0.094876304,-0.108908385,-0.06099019,-0.018583557,-0.09832761,-0.031879112,0.016933158,0.046637792,0.023286993,0.004421214,-0.05169699,-0.013627088,0.053887174,-0.07643558,0.07405207,-0.01043869,-0.0018861634,0.05679787,-0.05403563,-0.03682271,-0.006735169,0.03625423,0.099143736,-0.00042988372,0.0067121997,-0.07860534,0.0019838656,-0.060324073,-0.022783287,-0.010094072,0.015553469,0.05265144,-0.03396711,-0.030590372,0.013933891,0.047592107,-0.004093049,-0.13107502,-0.055086266,0.027742065,-0.010207947,0.098028325,0.08279357,0.0056836326,-0.023672871,0.023230169,0.06306394,0.036981925,-0.093292825,0.07996271,-0.014871468,-0.05918585,-0.057377018,0.0005285722,0.054199398,-0.041124467,0.07257614,0.08872655,-0.030447084,0.043798365,-0.096021704,2.0200174e-33,0.13888235,0.06586788,0.0275372,-0.039998427,-0.049712006,-0.002542593,-0.049798734,0.038561773,-0.007558893,-0.004236186,-0.076774694,0.0009860826,0.078580394,0.06137988,0.0059857713,0.073524274,-0.00022033422,0.010201388,0.06245023,0.0010148048,-0.0071684327,0.066193625,-0.10055193,0.011788933,0.032820977,0.03013869,-0.053700324,0.042829547,0.011815922,0.012191244,-0.0021750438,-0.09852166,-0.09431104,0.062967196,0.048703063,-0.030022467,0.024087433,-0.03374201,0.033729684,-0.033673886,0.03420315,-0.016154526,0.042592037,-0.045215316,0.0046232026,-0.049072575,-0.032757904,0.007712118,0.020072686,0.092521824,-0.021354321,-0.062555835,0.1343853,-0.02644764,-0.036810074,0.03475612,-0.008734334,-0.061020482,0.07696445,0.05890799,-0.023426428,0.0038336155,-0.032662794,-0.029058471,-0.018880045,-0.0009324121,-0.06377236,-0.056142464,-0.023063738,0.064973675,-0.058966268,-0.04032544,-0.00866114,0.03092808,0.012423652,-0.046124063,0.013940073,0.06616006,-0.001433369,0.042874467,0.027556097,-0.043971725,-0.0038409382,0.0143144075,-0.06814227,0.044591423,0.035184313,-0.04804454,-0.043028135,0.06575801,-0.040449824,-0.061162356,-0.07518807,0.06798112,0.061748534,-3.757978e-33,0.13613619,-0.08137399,0.0035635477,-0.087380536,-0.075437,0.07407581,0.1110155,-0.006428906,0.004279104,-0.0548137,0.066496365,0.002385472,-0.0007037878,-0.052000385,0.04740838,0.00713907,0.030246124,0.070545025,-0.027617985,0.023314128,-0.008440065,0.109606855,-0.026440261,0.046392415,0.02909436,-0.04064377,0.036041144,0.06285583,-0.042905748,0.06114905,-0.027189039,-0.007175297,-0.038560957,-0.039293356,-0.039165378,-0.017727736,-0.006228382,-0.058650702,-0.03250732,-0.001987882,0.009831847,0.070290364,0.014709115,0.029768014,0.069584,0.06531326,-0.077336036,0.031760395,-0.04875887,-0.046093155,-0.007870894,0.029794825,0.05147405,-0.019076021,0.0359015,0.017803287,0.019998275,0.05059675,-0.023987692,-0.029367864,-0.048165355,-0.009738512,-0.0027636779,-0.025297685,0.038565405,0.08949662,-0.020694356,-0.009800296,0.026118316,0.058463234,0.0066590304,-0.08292551,0.057558157,0.061623912,-0.046261664,-0.051841687,-0.059614476,-0.00022333198,0.047093328,-0.09599548,0.053650804,0.0037566796,0.022801634,-0.07596649,0.0060493825,-0.00348975,0.06437652,0.10265917,-0.014419841,0.034877636,-0.04058059,-0.007326525,-0.091611005,0.02583107,0.059712607,-5.247019e-08,0.0712788,0.0056222444,0.009263609,-0.01623316,-0.012853003,0.028018119,0.061232697,0.057912778,0.06603837,-0.0670316,0.0049778903,0.14126612,0.05080962,0.025133794,0.00786275,0.022626022,-0.02210445,0.04062308,-0.0059007388,0.04430998,-0.032275993,-0.05812873,-0.09718192,-0.006516542,0.019879464,-0.06747773,0.06149988,0.022651687,0.012210507,-0.028896574,-0.061420634,0.013594971,-0.006228467,-0.0776668,0.013150693,0.04213902,-0.050323952,-0.031072771,0.015789855,0.014248357,0.02768932,0.007172303,-0.03675838,0.020807166,-0.00904049,0.023902977,0.031078521,0.037131596,0.010891017,-0.022761123,0.0036206145,0.010785736,-0.037414346,-0.14137892,-0.08605954,-0.053093605,-0.025026051,-0.0670514,0.008730879,-0.039013952,0.08077095,0.008148702,0.11299363,-0.032083277 +2.4.1.359,"The enzyme, characterized from the halotolerant bacterium Marinobacter adhaerens, is likely responsible for degradation of the compatible solute 2-O-alpha-D-glucopyranosyl-glycerol when the environmental salt concentration decreases. cf. EC 2.4.1.332, 1,2-alpha-glucosylglycerol phosphorylase.",384,1.0,-0.04050083,-0.08069493,-0.06482336,-0.028017743,0.05687602,0.0041296026,-0.055106312,0.050054237,0.06843628,-0.041133765,0.020060662,-0.010295774,-0.017618839,0.07881685,-0.11112329,-0.00935053,-0.059229117,-0.021650482,-0.06888079,-0.020956162,0.04966655,0.051320154,-0.06997336,-0.002375004,0.007924152,-0.010308794,0.01769758,-0.04260868,-0.065101646,-0.023635685,0.041616358,-0.061844543,0.08255357,-0.022904973,0.1212563,0.07279913,-0.050330132,-0.0761439,0.048053134,0.048247885,0.012892902,0.016624238,-0.02852952,0.0294031,-0.05414019,0.009659552,-0.0210358,-0.00933651,0.047522753,-0.008535446,-0.01307766,-0.015217306,-0.07018248,-0.06645165,0.0172837,0.045193337,-0.07589679,0.026376352,-0.022775512,-0.0060810894,0.055724505,0.05955279,0.008011033,0.018041661,-0.04667654,-0.05572706,0.11197628,-0.12556915,0.0035117145,0.007006492,-0.093036376,-0.020948172,0.038675595,-0.005762412,0.019126067,-0.028305817,-0.04371403,-0.05957755,0.03195446,-0.07212773,0.08871404,-0.06851489,0.007232686,0.031971395,-0.012357729,-0.036482353,0.013490548,-0.077001646,0.09892542,0.01361157,0.018497549,-0.07406316,0.03777798,-0.06251338,-0.050253607,0.034459196,0.040141523,-0.050162736,-0.02252996,-0.03223577,-0.061049554,0.03206902,-0.0029396387,-0.087036766,0.001263734,0.041307,0.01245592,0.089026965,0.021732196,0.047798567,0.0418096,0.094308056,0.037632942,-0.0039684614,-0.015451781,0.05859554,0.052261844,-0.04896618,-0.11680132,0.030338513,0.008217222,-0.10558907,0.009822201,0.046992768,-0.04918427,0.12350891,-0.041187488,2.0816752e-33,0.11228008,0.02824937,0.028452313,-0.06811776,-0.024234967,-0.06905182,-0.060886875,-0.0015824869,-0.073438875,-0.0989907,-0.015208732,-0.036489133,-0.03592112,0.046912644,0.016694637,0.058474146,0.0068298914,0.052567504,0.073319845,0.01761892,0.016206313,0.028070802,0.015090374,0.012802926,0.06038311,0.069537394,-0.0103749465,0.014295002,0.058632743,-0.0042130505,0.030623045,-0.09666358,-0.10742715,0.058029044,0.07916234,0.029065361,-0.06199627,-0.019123448,0.08357521,0.01653793,-0.04177348,0.05024217,0.044811998,-0.002257024,0.08400798,-0.011947386,-0.030614965,0.08633377,0.021678682,0.033219196,-0.02400898,-0.031668976,0.06510379,0.052384745,0.03621103,0.03668486,0.010699217,-0.016748333,0.024215996,0.051241312,0.06843043,0.11638426,-0.012684869,-0.002520025,0.054417785,0.012339649,-0.0907682,-0.029413946,0.0044418387,0.018085018,-0.020472387,-0.039305575,0.04929523,0.061711814,-0.016391454,-0.08251927,0.044329327,0.025156947,-0.028649243,-0.055822834,0.025630362,-0.024430567,0.03775755,0.0125002405,-0.06644889,0.036463495,0.0012840389,-0.05417926,-0.03579209,0.08655625,0.0055263685,-0.0020346374,-0.055206288,0.030121673,-0.043842934,-2.409685e-33,0.108933546,-0.072370246,0.026088735,0.012534298,-0.03619054,0.012410815,-0.0013709919,-0.02809223,0.011550627,-0.03275654,0.0120632695,0.026471483,-0.0077436934,-0.07353596,-0.016074581,-0.026236529,0.012719242,0.08735864,-0.06777552,-0.04454654,0.003939139,0.039896917,0.018815352,0.0028012218,0.024659853,-0.032310896,-0.040289443,0.055931363,-0.058110036,0.038139198,0.05362115,0.07188021,-0.01856434,-0.074162826,-0.03763471,0.01366263,-0.07350086,-0.042019445,-0.009959913,0.015466283,-0.0023833516,0.005152786,0.035666883,-0.009605851,0.07194372,0.04833023,0.0081103835,-0.05663491,0.019653907,-0.073094524,-0.014187437,-0.035106257,-0.027936395,0.048548497,0.018349992,0.10146765,0.050714325,0.08941602,-0.047083326,-0.038484193,0.011406647,-0.009776533,0.05940146,-0.0050732293,0.07393737,0.052413557,0.042599946,0.081638575,0.01515953,0.067541994,0.025670288,-0.035622433,0.039145138,0.05261518,-0.039961725,0.022033013,-0.14209767,-0.01527254,0.011535487,-0.038546827,-0.017470658,0.028880933,-0.011547223,-0.023872446,-0.03477414,-0.09929521,0.036704876,0.04607035,-0.06310561,0.051449228,-0.048779298,-0.09727455,-0.06658956,-0.02406831,0.08554891,-4.0142318e-08,0.060795728,0.020243306,-0.033873666,-0.082929425,0.0009331172,0.020085355,0.051454987,0.047728613,0.051265087,-0.053603616,-0.055593103,0.041947685,0.04766545,-0.039425127,0.021732891,0.059578855,-0.015056918,-0.022138325,-0.036412504,0.021747729,-0.043683104,-0.006648246,-0.113063745,0.013409904,-0.021263907,-0.05978275,0.08076024,0.09608311,-0.048021473,0.030628143,-0.00044204004,-0.010487266,-0.0036775435,-0.06444036,0.01430554,0.008907564,-0.117781475,-0.021529702,-0.002880468,0.07758488,-0.03392255,0.08487542,-0.09270726,0.061134264,0.04441824,0.052566715,0.047485143,0.040805936,-0.018897956,0.023675563,0.064677894,0.009380474,-0.08310484,-0.06063238,-0.12174995,0.006213471,0.0011758072,-0.042672303,-0.0652577,-0.02416647,-0.0064167315,0.0023848338,0.10753291,-0.008798989 +2.4.2.61,This eukaryotic enzyme catalyses a step in the biosynthesis of the glycan moiety of the membrane protein alpha-dystroglycan. It is specific for the second ribitol 5-phosphate in the nascent glycan chain as acceptor.,384,1.0,-0.04813607,-0.007531165,-0.094445966,-0.022843612,-0.02529396,-0.079236835,-0.011639236,-0.004556441,0.018925427,0.024390653,-0.044550885,0.081695594,-0.039020784,0.035978906,-0.08949923,-0.012404533,-0.08229813,0.0109921135,-0.045103848,-0.023098387,0.1043663,0.0045540603,-0.022440946,-0.022731448,-0.0051594437,0.010917951,0.041698024,-0.019937411,-0.01307381,-0.09003671,-0.071128495,-0.119887434,0.04735574,-0.0261428,-0.004939537,0.093886554,-0.047250632,0.010695495,-0.022164164,-0.022457968,0.04356419,-0.024035743,0.01408415,0.022566933,-0.017667517,-0.014122014,-0.06853604,0.03961652,0.04739975,0.026295915,-0.017632207,-0.029514536,-0.06394863,-0.032528333,0.070734695,0.011482797,-0.029752688,0.033001497,0.06631996,0.0012128802,0.040415674,-0.017957332,0.005511174,0.0057938257,0.05976825,-0.12449424,0.08236858,-0.033444185,-0.04741853,0.024083786,-0.008087745,-0.04288865,-0.011292032,0.02443267,-0.0059872107,0.013697262,-0.04487476,0.03321182,0.05897526,0.0060988846,0.094902515,-0.013306096,0.052910317,0.09782738,-0.069134414,0.049262784,-0.028332643,-0.036027472,0.08825116,0.039706144,0.03356768,-0.02341177,0.0018923323,-0.010592118,-0.05769508,-0.011071261,0.04946246,0.021754645,-0.009205257,-0.033838194,0.038657017,0.0235724,-0.007783931,-0.046542987,-0.049488146,0.018832956,-0.03459127,0.09814902,-0.0028870024,0.00859545,-0.0060255635,0.028256336,0.036721267,-0.0037147487,-0.025485454,0.07874552,0.044443488,-0.045846157,-0.0035179856,-0.04312369,0.003093599,-0.0017450377,0.029691566,0.049665492,-0.07168763,0.025728395,-0.06784362,1.4916694e-33,0.052200347,0.064437315,0.009705289,-0.0005043587,-0.05451852,-0.040921263,-0.09595491,-0.05934026,-0.09703515,-0.03205692,-0.08269757,-0.05603388,-0.0029084198,0.025176687,-0.027571546,0.032516994,0.041048303,-0.006087922,-0.010504402,0.020146724,0.05331163,0.073926434,-0.005069145,-0.024269596,0.0922733,0.05148265,-0.052288454,-0.024983177,0.10006423,-0.0040062745,0.010136749,-0.076846264,-0.11285423,0.031045992,0.0592119,-0.028175404,-0.0031043056,-0.029160956,0.103124976,0.05128736,0.02054762,-0.051441297,0.0031975429,-0.0034848617,0.045588247,0.049213905,0.015144775,0.060770586,-0.013055385,0.019793434,0.04760864,-0.03615014,0.018511636,0.0033027632,-0.09456406,0.029540451,-0.0077645453,-0.046742253,0.011490345,0.10325355,0.05756728,0.054558963,0.008972696,0.018189516,-0.018896045,-0.033825357,-0.018940812,-0.02184583,0.009425886,0.06859439,-0.063884854,-0.036281697,0.14917316,0.043564543,-0.012414847,-0.03666889,0.023663247,0.005118732,-0.046005256,0.05414079,-0.05029769,-0.02589518,-0.018082662,-0.030495761,-0.011914815,0.079747185,-0.023073012,-0.12481473,-0.035133183,0.12431091,-0.02054905,-0.043426823,-0.075280264,0.057715323,-0.070749834,-3.5686488e-33,0.089265935,-0.1846088,0.11232547,-0.02744852,-0.06252657,0.0437469,-0.041331656,-0.080377325,0.05528219,-0.002093251,0.0014079614,0.031593516,0.073431574,-0.016512219,0.026217138,0.008243456,-0.019077761,0.08314269,-0.038612008,-0.004262724,0.017037416,0.052664373,-0.05248686,0.027372207,0.007662354,-0.0075314776,0.040263038,0.053792518,0.033939317,0.032785613,-0.033376575,0.0094933305,-0.015275719,-0.0033922624,-0.08252687,0.0755441,-0.020904753,-0.00787034,0.002553494,-0.010086638,-0.03949561,0.0745165,0.008672928,-0.008550246,0.025175814,0.07296498,0.02617891,0.08539154,-0.02037786,-0.059978407,0.09528439,0.011881748,0.008020843,0.11736406,-0.0043334397,0.07388604,0.035312507,0.050904896,-0.005505992,0.05290024,-0.030997358,-0.07607279,0.012937822,-0.078225,0.08369988,0.06842737,-0.003562629,-0.008865839,-0.0045153727,-9.8074015e-05,0.023170302,-0.025503067,-0.01382805,0.06968418,0.03211901,0.041046295,-0.10360437,-0.06429807,-0.010442703,-0.020238003,-0.042999744,0.07894099,0.024307253,-0.021246215,0.04328805,-0.09854862,0.079882205,0.13244136,-0.008613675,0.042951576,-0.008613609,-0.038918007,-0.04657093,0.040178854,0.042805295,-3.2946392e-08,0.039550964,-0.020122176,-0.035786465,-0.1044958,-0.025073832,0.02706372,0.030391159,0.0009927502,0.011501482,-0.02541293,-0.0545099,0.04334676,-0.003607785,-0.07520949,0.010538948,0.06942562,-0.045101013,0.02133034,-0.01885914,0.0026759577,-0.016932614,-0.019620186,-0.12686884,0.042503625,-0.06349818,-0.05393533,0.03936119,0.003524503,-0.008807108,-0.042385433,-0.027603703,0.026606636,-0.03761869,-0.05878563,-0.0653593,0.010878605,-0.0019078773,-0.06772645,0.052760027,0.009563976,0.051038932,-0.060671784,-0.013812318,0.014794029,-0.12775338,0.0112721445,-0.04516214,-0.030096358,-0.013769559,0.0503731,0.043743104,0.04033234,-0.011957813,-0.08550364,-0.092197165,-0.026962547,-0.03713578,-0.061641224,0.0013792951,0.021926008,0.0042518717,0.008779663,0.17930588,-0.073823385 +2.7.1.224,"The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides.",384,1.0,0.00086935156,0.028984573,-0.09856696,0.0005869564,0.040496964,0.05189975,0.040568266,0.035439532,0.087225884,0.06917126,0.042680837,-0.019494582,-0.0071491254,0.057452094,-0.019974787,0.004811077,-0.061425626,0.034169238,-0.028686112,-0.021539807,0.06917823,0.0103509575,0.047937796,-0.000493271,0.0043237237,-0.055889405,0.07686529,-0.022352364,-0.041124962,-0.025756212,-0.007620384,0.00246204,0.032421198,-0.059269976,0.063910976,0.08982122,0.02302803,-0.06664525,0.11036324,0.021164235,0.032886125,0.019212434,0.04443041,-0.024027742,-0.065925635,-0.0012164997,-0.016136149,0.07541367,0.030929375,-0.08978796,-0.09499366,-0.09178174,-0.03332389,-0.019023865,0.019813422,0.07926299,-0.015557064,-0.04241991,0.032004714,0.0015403631,-0.04878791,0.052604623,0.0979213,0.022182975,-0.014666444,-0.08363408,0.052344806,-0.084867395,0.0071961596,-0.004441503,-0.092125356,0.0024367566,-0.034881286,0.0013984918,0.01796247,-0.019820297,0.0030216437,0.057617825,0.033969846,-0.0016653613,-0.041049663,-0.05642494,0.06212653,0.019022139,-0.0740426,-0.031477127,0.042021062,0.022736654,0.12969102,0.050341588,0.008542363,-0.03938596,0.0111460695,-0.058485717,-0.09279579,-0.073520295,0.050935205,-0.013554468,0.101550885,0.016497774,0.0007195698,-0.033718318,0.015489503,-0.052775163,-0.037136286,0.0012893567,0.04752552,0.046612877,0.03926249,0.016196277,0.009094557,0.07933765,0.035812914,-0.056650214,-0.10862455,0.0468432,0.031221127,-0.07905195,-0.06991845,0.007072823,0.039457418,-0.0932451,0.05959174,0.018354546,-0.03100279,0.052780464,-0.12358785,1.5116789e-33,0.059316892,0.017443227,0.05577579,-0.036229443,0.06821,-0.026857285,-0.06813882,-0.042755164,-0.053993348,-0.053640835,-0.1034281,-0.06591326,-0.0062011518,0.036937837,0.033499375,0.010385579,-0.06263002,0.026734076,0.033278137,0.032603465,-0.037880816,-0.023960741,0.039384525,-0.030023819,0.0681689,0.077575184,-0.03348593,-0.004545251,0.03803486,-0.010036915,0.1360456,-0.040657658,-0.12886786,0.02304801,0.08798305,-0.0028538378,-0.02453907,-0.040573068,-0.0028339697,-0.026684197,0.010056977,0.06364645,0.0013233003,-0.006070069,0.0174713,-0.03528761,-0.058713563,0.09896001,0.07881588,0.09279138,-0.00637868,0.017420445,0.06690549,0.027129376,-0.053720538,0.05058442,-0.015705612,-0.042957913,0.038730048,0.025589332,0.012451426,0.046914488,-0.039674427,-0.0018929532,0.008872122,0.032624163,0.01427433,-0.02916109,0.07369245,0.009487189,-0.04939046,-0.05701944,-0.028163256,0.08694956,-0.064677104,-0.071753494,-0.02593728,-0.034573052,0.028284054,-0.021964395,0.052987583,-0.028199747,0.018397704,-0.023263887,-0.11125658,0.00122026,-0.059168674,-0.0031049398,-0.056068566,0.037991073,0.033418372,-0.04496366,-0.028025324,0.02765713,0.0006445875,-3.602013e-33,0.041080307,-0.07182004,0.039441496,-0.060497154,0.0053073554,-0.03969165,-0.009809185,-0.053340554,-0.020556912,-0.08369863,0.029933192,0.051886838,0.037113313,0.0040199384,-0.0032013354,0.036898326,-0.010366752,0.095042445,-0.053820886,0.003394699,-0.015469418,0.049988307,0.007899804,-0.07558472,0.036409725,-0.018989569,-0.012135237,0.11666174,-0.046831757,-0.0007665793,-0.0069269384,0.009594664,-0.056704257,-0.0844883,0.0029765337,-0.043114796,-0.079250544,-0.05655492,0.06090029,0.006331237,0.04532478,0.02055179,0.009707362,0.032842368,0.019967228,0.09747613,-0.088270284,0.009814146,0.0026687274,-0.026630087,-0.070104204,-0.025837231,0.00846017,-0.017338762,0.018244028,0.059420295,-0.0068820645,0.009893483,-0.03704261,-0.069067374,-0.015878458,-0.022306552,0.06595329,0.012721316,0.029341217,0.050781302,0.04436962,-0.018347818,0.075478256,-0.08086883,0.08442533,-0.016700028,-0.013300865,0.073079236,-0.055792563,-0.04036699,-0.13524964,0.018619047,-0.040684897,-0.00611526,0.028425891,-0.035226364,0.006199031,-0.07045707,0.029830834,0.0030948957,0.050188795,0.07215719,-0.008307731,0.03666079,-0.014569306,-0.03842219,-0.02032422,0.10464879,0.03858786,-3.2075445e-08,-0.0034860296,-0.10151801,-0.034875102,-0.07051639,-0.022359736,0.004883256,-0.029357491,-0.040785957,-0.01922413,-0.041875713,0.039773118,0.13311018,-0.0060937963,0.053019915,0.014482816,0.043314364,-0.104258135,0.027275598,-0.040036008,0.028597122,-0.095343925,0.024028108,-0.032682598,0.059782013,0.025446795,-0.032017045,-0.007890767,0.09344029,-0.041317303,-0.0132761495,0.041729283,0.08959863,0.00050424854,-0.008018789,-0.119777724,0.034455582,-0.08505848,-0.023015108,-0.006227993,0.054320604,0.058670986,-0.006330845,-0.074706234,0.00028922927,-0.004056461,0.06777663,-0.030937543,0.07951412,-0.075341135,0.0016213834,0.029248554,0.029264351,-0.07865119,0.010344326,-0.08677532,-0.017234735,0.0017644361,-0.008327801,0.02922169,-0.031426266,0.030024795,0.0056703757,0.12585841,-0.1039741 +2.7.7.101,"The enzyme catalyses the synthesis of short RNA sequences that are used as primers for EC 2.7.7.7, DNA-directed DNA polymerase. It is found in bacteria and archaea. The latter also have a second primase system (EC 2.7.7.102, DNA primase AEP).",384,0.99999994,-0.06442527,0.0017151312,-0.01577215,-0.021935416,0.06915895,0.053088445,-0.1193448,0.089750566,-0.029477566,0.02122912,0.032914747,0.002084033,-0.106050394,-0.032419566,-0.022481928,0.030150356,-0.11402212,-0.025619738,0.029862542,-0.098473,0.043175705,0.049589716,-0.030557163,0.013102608,-0.045906685,0.04297398,0.0952994,-0.015379291,0.012595513,-0.09250306,0.036722276,-0.06887133,0.11303831,0.0024242224,0.038420264,0.038420863,-0.01133328,-0.07571301,0.03063597,0.034907896,0.100718625,-0.018521117,-0.018969987,-0.060386244,-0.069176935,-0.010129511,0.03664727,0.021501377,-0.025745224,-0.030809045,-0.04126781,-0.0066719516,-0.04301944,-0.043175645,0.019969033,0.041439038,-0.020337101,-0.109387584,-0.009349641,-0.018100185,0.035391513,-0.015521381,-0.0095783435,-0.015490767,0.039970074,-0.050898846,0.11568547,-0.021359188,-0.006994755,-0.0048784353,-0.0493133,-0.054987375,-0.03252565,0.11842525,0.019515332,-0.0019528446,-0.003444009,-0.07163861,0.021092148,-0.030546928,-0.06950029,-0.04577736,-0.017916465,0.037851706,-0.020369107,0.026176142,0.047684938,0.028918212,-0.008724428,0.018407302,0.04841604,-0.07318181,0.022081781,-0.03747481,0.008311162,0.09008122,0.018345602,0.070714265,0.09716039,-0.06953006,0.032843765,0.058975883,-0.07508746,-0.09987865,-0.020396253,0.008107045,0.041878134,0.076636545,0.08682543,0.009677843,-0.001483661,-0.0067838803,0.034833577,-0.054706622,-0.008618428,0.017710375,0.0028752743,-0.044072792,0.023381488,0.03456302,0.04667319,-0.04073445,0.022577036,0.10804856,-0.017390499,0.019763848,-0.12819813,-1.5438498e-33,0.024345294,0.018255603,0.02520434,-0.06049632,-0.06425211,0.039741956,-0.048138216,0.06870608,-0.12156944,-0.055577286,-0.028308772,-0.08959541,0.016798936,-0.011393468,-0.02540654,-0.058023494,0.054494627,0.02859228,-0.041828662,-0.026004596,-0.012749278,0.033842135,-0.0003331241,0.041795317,0.07312217,0.060728755,0.041262902,-0.056833442,0.067453995,-0.02200081,-0.03320865,-0.08016686,-0.08270369,0.118930034,0.022974908,-0.00017580393,0.02127683,-0.049078166,0.021144414,0.102281176,-0.010805025,0.041232724,0.03201038,-0.04123102,0.046128847,-0.050601542,-0.036795374,0.064064056,0.0074797566,0.0004583514,0.05535772,-0.046080735,0.025508683,-0.022659842,0.04605999,0.062732816,-0.0691327,-0.034251988,0.04612223,0.080330804,0.017402075,0.07302529,-0.0724228,0.055685908,0.015740972,0.033424478,-0.030295616,-0.03345149,0.024515362,0.1084753,-0.02902715,0.013136623,0.08061819,0.030747449,0.04745673,-0.011771683,-0.07461872,-0.058783043,-0.0068579763,0.055062458,-0.07582428,0.009391871,-0.041018955,0.050946783,-0.040220443,-0.0043008914,-0.05257544,0.00019051055,0.028327474,0.066895016,0.035681333,-0.08534492,-0.08344653,-0.004214446,-0.017344547,3.3823218e-34,0.08443775,-0.08389188,0.016697839,1.0646328e-05,-0.058804464,-0.016906267,0.02494112,-0.035800394,-0.025547288,-0.029874295,0.080645114,-0.027728511,0.14984858,-0.114546,0.038417768,0.007482187,0.009212513,0.020323308,0.0043893275,0.0029868556,0.076084554,0.036721922,-0.044089563,0.022703605,0.044147998,-0.060022227,-0.04087062,0.081052646,0.0073776264,0.023017444,-0.07668395,0.00619806,-0.017234473,-0.027995197,-0.0696069,0.041026227,-0.026363257,0.020788508,-0.014911881,-0.021999301,-0.029295968,0.0465443,0.003465795,0.053592186,0.0033567427,0.07610974,0.011952412,0.06831313,0.052803975,-0.019032773,0.036776256,-0.059043467,-0.004312007,-0.007608734,-0.014493605,-0.041757837,-0.013611232,0.011791925,0.055488024,-0.034649435,-0.013951776,-0.07727038,0.06701759,0.014823245,0.033902414,0.016705513,-0.06283082,0.06895003,-0.03714863,-0.0766022,0.09482924,-0.0038635011,-0.005611245,0.045640238,0.0071227653,0.0131385615,-0.07322281,-0.006759421,0.0072771893,-0.03204361,0.01748864,-0.017674746,-0.007860172,-0.07948302,-0.0028663047,0.034471534,0.10040094,0.08009257,-0.059611067,0.049161997,-0.07416578,0.010903813,0.037944544,0.06691798,0.00039671242,-3.2866808e-08,-0.03724642,-0.04778655,0.06196942,-0.038200393,0.0673376,0.044660434,0.022329867,0.06889849,0.08709967,-0.030505,-0.03177056,0.027594551,0.031334043,-0.013892065,0.10275047,0.0023557218,0.024445554,-0.013043961,-0.008127589,-0.014535873,-0.045545682,0.047642883,-0.12546206,0.0021975809,-0.076794624,-0.00541902,0.07282253,0.021863773,0.027187293,-0.088354975,-0.04744211,0.049724646,0.04698099,-0.035737034,-0.048028227,0.008928876,0.05312979,-0.016182452,-0.0002413179,0.023178669,0.0056342348,-0.023305254,-0.08908548,-0.045524184,-0.037494782,-7.909585e-05,0.041976444,0.019794151,-0.0334017,-0.015551399,0.075891726,-0.064808674,0.050735254,-0.061420683,-0.005656494,0.0041452562,-0.03200071,-0.09446997,-0.041909665,-0.018100515,0.044928383,-0.00041937243,0.17072143,0.005607818 +2.7.7.102,"The enzyme, which is found in eukaryota and archaea, catalyses the synthesis of short RNA or DNA sequences which are used as primers for EC 2.7.7.7, DNA-directed DNA polymerase.",384,1.0,-0.038492836,0.021715572,-0.055053506,0.0066775847,0.06369024,0.02787398,-0.10421233,0.041102733,-0.0137530845,0.039372362,0.00526439,-0.020158773,-0.11405373,-0.015507721,-0.017166963,0.04107314,-0.10572677,-0.020303704,0.030613396,-0.089972414,0.039374262,0.061680585,-0.0034079775,0.018313881,-0.048036695,0.039262787,0.08855207,-0.07285439,-0.006816454,-0.07307558,0.01156397,-0.07446428,0.09017863,0.0046583363,0.02646846,0.041830815,-0.03583579,-0.07501488,0.02015718,0.029860163,0.09817171,-0.023190832,-0.0022736606,-0.042081896,-0.09004511,0.0013452112,0.050111618,0.019218946,0.0046089184,-0.009367464,-0.04538585,-0.02214789,-0.076875925,-0.051368285,0.008909569,0.03368894,0.00389244,-0.097204745,0.0074311467,-0.007865194,0.05838489,-0.023230866,0.013893211,0.006034981,0.02316104,-0.09213081,0.10898686,-0.03522207,-0.018155897,-0.01075975,-0.043196883,-0.05324541,-0.046105616,0.09478856,-0.0045999195,-0.0033068385,-0.0018727654,-0.0815696,0.009134264,-0.01523177,-0.026190065,-0.032844048,-0.024997467,0.023751048,-0.022626512,0.04103982,0.062193953,0.015802125,0.031634845,0.0081150355,0.054615237,-0.046222888,0.024417307,-0.055121895,-0.01536248,0.06553247,0.031338867,0.08033683,0.09936999,-0.05715507,0.042202216,0.08239103,-0.08003535,-0.10384913,-0.046462744,0.0006354551,0.030527147,0.09530598,0.07232442,0.028854802,-0.007597299,-0.010501037,0.06144102,-0.02984982,-0.0024817882,0.010426317,0.009833649,-0.03799353,-0.00802723,0.08128292,0.04875491,-0.038187515,0.018075153,0.10714347,-0.0135387415,0.028686592,-0.14141382,-1.4768648e-33,0.025626773,0.011110541,0.01598323,-0.04186511,-0.027463935,0.030631818,-0.052418824,0.047295924,-0.10035436,-0.06342697,-0.05772205,-0.06203823,0.036910925,0.008581795,-0.023841508,-0.042803843,0.04414753,0.026391596,-0.039109305,0.024653876,-0.005619903,-0.0074797934,0.0038445608,0.048724156,0.02382028,0.045127295,0.05598936,-0.03654304,0.07511093,-0.028865114,-0.036187217,-0.09121937,-0.10344037,0.10509452,0.049853373,-0.010684648,0.02055347,-0.04921745,2.9117942e-05,0.079377614,-0.022202153,0.02090112,0.01933571,-0.0458942,0.06446656,-0.07083685,-0.041374344,0.0787673,-0.012011744,0.009631327,0.05275284,-0.04457296,0.0604776,-0.034565847,0.027939603,0.061530646,-0.04744367,-0.040507298,0.058204703,0.08589037,-0.026326114,0.04630453,-0.047078744,0.05663168,-0.004327273,0.03532246,-0.008976344,-0.015643867,0.026603118,0.084848076,-0.018499581,-0.01294216,0.06680409,0.046881873,0.03196371,-0.029444098,-0.12332965,-0.08337601,-0.028775197,0.059082944,-0.055776928,-0.015971621,-0.025967706,0.032673225,-0.011544562,0.0013028075,-0.083944626,0.00026967854,0.025260843,0.054623336,0.04397349,-0.07836773,-0.086399175,0.0030628345,0.024150752,-9.285378e-34,0.0942262,-0.096747085,-0.010372886,-0.020248128,-0.06708244,-0.02797042,-0.014828541,-0.029298082,-0.0042777043,-0.03798242,0.0626388,-0.03373537,0.11664449,-0.085313894,0.03751722,-0.008148302,0.009726819,0.030514572,0.0032621524,0.014875146,0.064137325,0.0027311973,-0.04915852,0.016117234,0.03895463,-0.04930891,-0.03924216,0.06001186,0.015627492,0.030845087,-0.094416186,-0.02348864,-0.01622643,-0.029221473,-0.05321271,0.03815938,-0.010363609,0.0013282233,0.025982738,-0.016229466,-0.0032733097,0.06902169,0.011169506,0.05228619,-0.0063510463,0.053939775,-0.035697326,0.076658025,0.051717166,-0.035687197,0.042754762,-0.055116024,0.026306028,-0.044599526,-0.009105979,-0.020167347,-0.014972016,0.012402723,0.04664082,0.009642706,-0.043984503,-0.071217515,0.092914514,0.034424845,0.011458769,0.026089901,-0.051607277,0.060059473,-0.02501606,-0.066929735,0.10735675,-0.0024118053,-0.016079256,0.059154633,0.0021683811,0.0015892241,-0.06614809,-0.018186554,0.0013361928,-0.01587563,0.05439568,-0.04560042,-0.0036697027,-0.07970472,-0.015873218,-0.018650737,0.10061084,0.077149965,-0.08272667,0.056671247,-0.040527612,-0.019334389,0.027608316,0.061131924,0.029612336,-3.011503e-08,-0.03149165,-0.057050936,0.059970055,-0.05695901,0.06208952,0.067907885,0.042073898,0.05807955,0.07905708,-0.04143843,-0.011429466,0.033158597,0.027199764,0.027917234,0.09933331,0.03154803,0.03474411,-0.008488512,0.00024410097,0.016489957,-0.03270898,0.024513926,-0.123993434,0.030332424,-0.074176684,-0.015658801,0.0598125,0.04560421,-0.008903603,-0.09831615,-0.09284241,0.040810402,0.026248116,-0.026021827,-0.05303764,0.013210455,0.04827265,-0.047266312,-0.008008642,0.015123211,0.00025917462,0.011667567,-0.09441382,-0.07812655,-0.03751815,-0.0005661641,0.034922596,0.043231346,-0.060235634,-0.002773478,0.07001723,-0.043282308,0.05430019,-0.0918816,-0.02548717,0.02237438,-0.031520046,-0.098470904,-0.048595246,0.0044388156,0.044725467,0.017130686,0.20050587,-0.031566814 +2.7.7.103,"The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides.",384,1.0,0.00086935156,0.028984573,-0.09856696,0.0005869564,0.040496964,0.05189975,0.040568266,0.035439532,0.087225884,0.06917126,0.042680837,-0.019494582,-0.0071491254,0.057452094,-0.019974787,0.004811077,-0.061425626,0.034169238,-0.028686112,-0.021539807,0.06917823,0.0103509575,0.047937796,-0.000493271,0.0043237237,-0.055889405,0.07686529,-0.022352364,-0.041124962,-0.025756212,-0.007620384,0.00246204,0.032421198,-0.059269976,0.063910976,0.08982122,0.02302803,-0.06664525,0.11036324,0.021164235,0.032886125,0.019212434,0.04443041,-0.024027742,-0.065925635,-0.0012164997,-0.016136149,0.07541367,0.030929375,-0.08978796,-0.09499366,-0.09178174,-0.03332389,-0.019023865,0.019813422,0.07926299,-0.015557064,-0.04241991,0.032004714,0.0015403631,-0.04878791,0.052604623,0.0979213,0.022182975,-0.014666444,-0.08363408,0.052344806,-0.084867395,0.0071961596,-0.004441503,-0.092125356,0.0024367566,-0.034881286,0.0013984918,0.01796247,-0.019820297,0.0030216437,0.057617825,0.033969846,-0.0016653613,-0.041049663,-0.05642494,0.06212653,0.019022139,-0.0740426,-0.031477127,0.042021062,0.022736654,0.12969102,0.050341588,0.008542363,-0.03938596,0.0111460695,-0.058485717,-0.09279579,-0.073520295,0.050935205,-0.013554468,0.101550885,0.016497774,0.0007195698,-0.033718318,0.015489503,-0.052775163,-0.037136286,0.0012893567,0.04752552,0.046612877,0.03926249,0.016196277,0.009094557,0.07933765,0.035812914,-0.056650214,-0.10862455,0.0468432,0.031221127,-0.07905195,-0.06991845,0.007072823,0.039457418,-0.0932451,0.05959174,0.018354546,-0.03100279,0.052780464,-0.12358785,1.5116789e-33,0.059316892,0.017443227,0.05577579,-0.036229443,0.06821,-0.026857285,-0.06813882,-0.042755164,-0.053993348,-0.053640835,-0.1034281,-0.06591326,-0.0062011518,0.036937837,0.033499375,0.010385579,-0.06263002,0.026734076,0.033278137,0.032603465,-0.037880816,-0.023960741,0.039384525,-0.030023819,0.0681689,0.077575184,-0.03348593,-0.004545251,0.03803486,-0.010036915,0.1360456,-0.040657658,-0.12886786,0.02304801,0.08798305,-0.0028538378,-0.02453907,-0.040573068,-0.0028339697,-0.026684197,0.010056977,0.06364645,0.0013233003,-0.006070069,0.0174713,-0.03528761,-0.058713563,0.09896001,0.07881588,0.09279138,-0.00637868,0.017420445,0.06690549,0.027129376,-0.053720538,0.05058442,-0.015705612,-0.042957913,0.038730048,0.025589332,0.012451426,0.046914488,-0.039674427,-0.0018929532,0.008872122,0.032624163,0.01427433,-0.02916109,0.07369245,0.009487189,-0.04939046,-0.05701944,-0.028163256,0.08694956,-0.064677104,-0.071753494,-0.02593728,-0.034573052,0.028284054,-0.021964395,0.052987583,-0.028199747,0.018397704,-0.023263887,-0.11125658,0.00122026,-0.059168674,-0.0031049398,-0.056068566,0.037991073,0.033418372,-0.04496366,-0.028025324,0.02765713,0.0006445875,-3.602013e-33,0.041080307,-0.07182004,0.039441496,-0.060497154,0.0053073554,-0.03969165,-0.009809185,-0.053340554,-0.020556912,-0.08369863,0.029933192,0.051886838,0.037113313,0.0040199384,-0.0032013354,0.036898326,-0.010366752,0.095042445,-0.053820886,0.003394699,-0.015469418,0.049988307,0.007899804,-0.07558472,0.036409725,-0.018989569,-0.012135237,0.11666174,-0.046831757,-0.0007665793,-0.0069269384,0.009594664,-0.056704257,-0.0844883,0.0029765337,-0.043114796,-0.079250544,-0.05655492,0.06090029,0.006331237,0.04532478,0.02055179,0.009707362,0.032842368,0.019967228,0.09747613,-0.088270284,0.009814146,0.0026687274,-0.026630087,-0.070104204,-0.025837231,0.00846017,-0.017338762,0.018244028,0.059420295,-0.0068820645,0.009893483,-0.03704261,-0.069067374,-0.015878458,-0.022306552,0.06595329,0.012721316,0.029341217,0.050781302,0.04436962,-0.018347818,0.075478256,-0.08086883,0.08442533,-0.016700028,-0.013300865,0.073079236,-0.055792563,-0.04036699,-0.13524964,0.018619047,-0.040684897,-0.00611526,0.028425891,-0.035226364,0.006199031,-0.07045707,0.029830834,0.0030948957,0.050188795,0.07215719,-0.008307731,0.03666079,-0.014569306,-0.03842219,-0.02032422,0.10464879,0.03858786,-3.2075445e-08,-0.0034860296,-0.10151801,-0.034875102,-0.07051639,-0.022359736,0.004883256,-0.029357491,-0.040785957,-0.01922413,-0.041875713,0.039773118,0.13311018,-0.0060937963,0.053019915,0.014482816,0.043314364,-0.104258135,0.027275598,-0.040036008,0.028597122,-0.095343925,0.024028108,-0.032682598,0.059782013,0.025446795,-0.032017045,-0.007890767,0.09344029,-0.041317303,-0.0132761495,0.041729283,0.08959863,0.00050424854,-0.008018789,-0.119777724,0.034455582,-0.08505848,-0.023015108,-0.006227993,0.054320604,0.058670986,-0.006330845,-0.074706234,0.00028922927,-0.004056461,0.06777663,-0.030937543,0.07951412,-0.075341135,0.0016213834,0.029248554,0.029264351,-0.07865119,0.010344326,-0.08677532,-0.017234735,0.0017644361,-0.008327801,0.02922169,-0.031426266,0.030024795,0.0056703757,0.12585841,-0.1039741 +3.1.1.104,"The enzyme, characterized from Mycoplasma spp., contains a binuclear metal center with two zinc cations. The enzyme is specific for the phosphorylated forms, and is unable to hydrolyse non-phosphorylated 1,4-lactones.",384,1.0,0.008587512,0.023433022,-0.073210806,0.00023082778,0.016495807,0.01553677,0.0037117123,0.08843664,-0.03744436,-0.012656788,-0.009293781,-0.07364501,0.033735484,0.032043412,-0.089232564,0.02395911,-0.026570747,0.04488221,-0.025594717,-0.043148246,0.0788693,0.0439991,0.03604582,-0.00020888334,0.08830183,0.036287956,0.014999898,0.028385486,-0.041188356,-0.08043938,-0.037855487,-0.078429505,0.018591562,0.0009629974,0.06816432,0.048565116,0.0037186232,-0.011523291,0.045520145,-0.0024575323,0.037247036,0.02481636,0.053141087,-0.07009987,-0.01904635,-0.008260442,-0.008958815,-0.029423546,-0.0046872646,0.071016796,-0.023290364,-0.05935807,-0.005791729,0.049786903,0.05387077,0.069689065,-0.07065627,-0.014061528,-0.0050899843,0.09870041,0.042273596,-0.014064826,-0.0061884862,0.06540598,0.06828045,-0.011795753,-0.0009641922,-0.025803024,0.018369593,-0.06348666,0.008637514,-0.018145204,-0.019419821,0.05906831,0.024474058,0.050116055,0.09349828,-0.06622893,0.057217516,0.07782067,-0.039563924,0.011004977,0.0038834303,-0.018269133,-0.0005269484,0.024180206,0.09750917,-0.027405413,0.028204009,0.04286804,0.022455482,-0.010217218,-0.11196271,-0.029541828,-0.02473418,0.0051821284,0.083198525,0.025545951,0.01470659,-0.025496125,0.10440411,-0.037140876,0.06443872,-0.094582014,-0.044582274,0.0302814,0.02520438,-0.017751068,0.020869216,0.0677038,-0.013110445,0.06709498,0.0033984766,0.045612138,0.039622232,0.11035526,0.071222305,-0.06665282,-0.049009595,-0.012395844,-0.03902651,-0.04435152,0.027546959,-0.00071905775,-0.05916448,0.036771495,-0.08598947,3.6255072e-34,-0.0010931297,-0.0005519106,0.04600527,-0.0034523539,0.059351854,-0.033824198,-0.08626623,-0.002998528,-0.09016198,-0.06119018,-0.0074647064,-0.009865871,0.016313355,0.0515711,-0.10395906,-0.029509123,0.09021786,-0.042874344,0.02013056,0.027570736,-0.031220917,0.056140278,-0.02791686,0.06119113,0.06412884,0.064239785,-0.011707046,-0.019700473,0.103601255,0.027760746,0.030730134,-0.06275275,-0.076941594,-0.004002109,0.1158817,0.02285793,-0.008301531,0.021991154,-0.0072340914,-0.015623383,-0.011293426,-0.034740023,-0.028058097,0.00942465,0.016831202,-0.11080547,-0.097747855,0.020338012,-0.030836651,-0.037021298,0.0522267,0.02034275,0.00033255847,0.0045845076,-0.024508256,-0.0056616147,-0.06415714,-0.012869386,0.04611989,0.095340185,-0.00055635785,0.1012517,-0.03731131,0.12901886,0.04968598,-0.077485,-0.070196815,-0.02634924,-0.039574575,0.058075115,-0.044158522,-0.05867939,0.05295685,0.005996059,0.036138054,-0.06376829,0.0025102582,-0.020913977,-0.029435206,-0.01235389,0.0043553784,-0.00780869,0.014304184,-0.04554019,-0.091612086,-0.041468497,-0.032956768,-0.039537724,-0.036899865,-0.03943983,0.059682764,0.019365009,-0.0622604,-0.0354811,-0.05566532,-3.5607057e-33,0.09996069,-0.07302027,0.12036307,-0.075947255,-0.050071236,0.0047768843,0.053793497,-0.0027215083,0.050312717,0.00028060394,0.07875212,-0.028443955,-0.008452073,-0.052344836,0.00021344623,-0.008288066,-0.020455843,0.0990496,0.018059192,0.031910658,-0.031589773,0.14321423,-0.022385245,0.0072176307,0.0051825223,-0.022230836,-0.11307076,0.044949546,-0.0020011119,0.028916262,-0.04164823,0.020807832,0.00013783788,-0.131158,-0.08124507,-0.020805154,-0.074523725,-0.07875739,-0.00174228,0.051278025,-0.060682945,0.030334948,-0.07084803,0.051476017,0.047307696,0.050769884,-0.064252205,0.026547477,0.021568857,0.01582619,-0.006919862,0.018369487,-0.0089571355,0.012159283,0.10719403,0.020839302,-0.01458059,-0.028197672,-0.018549304,-0.006806358,-0.020915043,-0.08087022,-0.0023585674,-0.04885772,0.09045675,0.04526703,0.00078382005,-0.02317652,0.025775444,-0.021939898,0.07267389,0.061466023,-0.059460178,0.013252175,0.009993977,-0.025957314,-0.08005385,0.029577365,-0.045056112,-0.061509665,0.03337919,0.051253475,0.068254225,-0.09828498,0.08005655,-0.08886756,0.013280085,0.09960422,-0.062157657,-0.0050881007,0.008741929,0.021616029,-0.10468424,0.07125477,0.012384927,-3.8347377e-08,0.004407913,-0.060394224,-0.024511382,-0.09034158,-0.0042558536,0.049543686,-0.010209182,-0.052279424,0.03737511,-0.004106297,-0.042540617,0.0793683,-0.035793692,-0.057576835,-0.0031589528,0.023725545,-0.04801907,-0.004834235,-0.026035357,0.03829751,-0.020658568,0.017646031,-0.10102104,0.044306993,-0.009893029,0.010254109,0.042486414,0.13759616,-0.09862541,0.008147019,0.009399237,0.009813696,-0.00841777,-0.09197115,-0.11551803,-0.016823765,0.0045665572,-0.026987957,-0.020429129,-0.030704148,0.024769934,-0.055670407,0.0482585,0.0002950601,-0.08232868,-0.0039727464,-0.026157355,0.007053946,0.07313021,0.039993733,-0.037207827,-0.012459024,-0.0022199717,-0.045483455,-0.025410783,0.036785673,0.0020732575,-0.015654305,-0.074712865,-0.06187024,0.0525933,-0.036796726,0.14091825,-0.04945067 +3.2.1.208,"The enzyme has been isolated from nontuberculous mycobacteria (e.g. Mycobacterium hassiacum), which accumulate 2-O-(alpha-D-glucopyranosyl)-D-glycerate during growth under nitrogen deprivation.",384,0.99999994,-0.06688002,-0.07935683,-0.114401706,0.0062623112,-0.0021001245,-0.033032726,-0.00873512,0.097223006,-0.028606052,0.012963826,0.009882688,0.030883892,0.008492713,0.019867543,-0.117554896,0.03134293,0.059258573,-0.035814617,-0.025964646,-0.035351597,0.028882563,0.0789778,-0.010908229,-0.09566831,0.080185264,0.0012754907,0.015213139,0.0005288504,0.034179065,-0.09176617,-0.039999537,-0.08801053,0.08702362,-0.04350106,0.15764982,0.025460148,-0.013488017,-0.04311229,0.061420564,0.018659297,0.033053663,-0.0060260184,-0.013461712,-0.010218519,-0.06545119,0.018524826,-0.03485114,0.020942999,0.041264847,-0.018824605,-0.029125106,-0.091106966,-0.0213717,0.020769106,0.04698612,0.010246348,-0.020851959,-0.0126378555,-0.024498772,0.04664522,0.07879206,0.057084654,0.08309392,0.008761564,0.05170962,0.008621025,-0.025236405,0.007949241,0.017996047,-0.02697629,-0.016789071,-0.0051023224,-0.033633415,0.055117145,-0.008449258,-0.03552444,-0.0019339073,0.0072866715,0.07840786,0.02260837,0.0022977204,0.009795076,0.03091465,0.0074005285,-0.058899987,-0.02121633,0.08098487,0.06185259,0.030093454,0.0030375868,-0.021568121,-0.016529813,-0.0070807626,-0.062053468,-0.024962047,-0.049018815,0.069505095,-0.022925226,-0.03158974,-0.050164558,0.0039118137,-0.015229918,0.06867644,-0.034623753,-0.11306997,0.037816312,-0.015194263,-0.0058508157,0.104851596,0.012527168,-0.03559903,0.07287435,0.029398967,0.0122941,-0.049745828,-0.020785466,0.13189183,-0.035365373,-0.09628153,0.034982145,0.03845937,-0.042453066,0.05471301,0.058807325,-0.07331214,0.09180743,-0.044818904,7.114064e-34,0.04627045,-0.055072457,0.009343339,-0.02854329,0.048549257,-0.038085777,-0.048250195,-0.02726556,-0.032274548,-0.011314681,-0.06847116,-0.07736788,0.03084342,0.021292798,-0.06961446,0.11258783,0.04822292,-0.02650865,0.10306921,0.051898763,0.046013944,0.022491843,-0.030238852,0.029422687,0.04934277,0.0487293,-0.052560743,-0.0019338205,0.07113147,-0.0062198644,0.041605745,-0.14881407,-0.09473592,-0.018644778,0.027496206,-0.03962683,-0.07277314,-0.022028167,0.026527239,0.030337913,0.024170747,0.01038185,0.0027321668,-0.049770128,0.08307143,0.022621758,-0.03964936,0.0034709503,-0.021643113,0.011381932,0.03756329,-0.08300915,0.013100649,-0.056157727,-0.0141955465,-0.02185805,-0.03721862,0.05123837,0.077454746,0.07801014,0.024890058,0.11844682,-0.029795185,0.0828394,-0.028086651,-0.03598811,-0.063197605,0.054565445,-0.01502177,0.062164214,-0.07180594,-0.020777505,0.021532433,-0.027632985,0.03507338,-0.15204443,-0.0032611697,-0.05291476,0.021762148,-0.06872014,0.049373884,-0.04674798,0.014141077,-0.014340229,-0.06580139,0.011483965,-0.07208334,-0.034343917,-0.028202713,0.025970675,0.0385433,-0.030797256,-0.1287836,0.022834763,-0.013619427,-2.9939303e-33,0.106698096,-0.09761349,0.07343981,-0.050799843,-0.04003663,0.033330884,-0.03141878,0.054803964,-0.005673888,0.013721228,0.06535131,0.028642984,-0.0140150795,-0.025684893,0.041558463,0.0076700887,-0.042951103,0.072104074,-0.019393738,-0.010569962,-0.021306386,-0.005880789,0.013312565,-0.1021138,0.016530143,0.008509288,-0.044028927,0.08051539,0.0016199662,0.060334526,0.011453465,0.05951577,-0.032861553,-0.14765097,-0.051486887,-0.023380775,-0.10188523,-0.08150724,0.011187956,-0.08512222,-0.022049977,0.07342815,0.0716566,0.05321088,-0.017217763,0.04984276,-0.06500235,-0.042088337,0.019472333,-0.0111200325,-0.004754916,-0.04578905,-0.021568293,0.039002318,0.013269313,0.06760975,0.06315627,0.0661064,-0.027627805,0.009564738,-0.0052459203,-0.10583127,-0.030236963,-0.0058400715,0.08654657,0.11244047,-4.765598e-05,0.10846318,0.022344792,0.022235619,0.021348536,-0.02018838,-0.006052398,0.03184071,-0.042129174,0.057308618,-0.027956843,0.007547099,0.015926396,-0.014739949,-0.06540163,0.004112483,-0.015086395,-0.08653141,0.05445895,-0.07823465,0.04028533,0.108660966,-0.018829213,0.069865495,-0.018731076,0.021222418,-0.08625409,-0.03376572,0.077296466,-3.7301536e-08,0.056947507,-0.05813674,0.03519798,-0.03433625,0.07721676,-0.010865623,-0.017610623,0.03463036,0.054683477,0.030931797,0.0022190965,0.031232646,-0.008074631,-0.034620572,0.04001438,0.074386194,-0.022342378,-0.050922696,-0.0131710805,0.008489186,-0.12470151,-0.013259031,-0.036043357,0.035470754,-0.021916058,-0.07527997,0.048671655,0.020859778,0.006282299,-0.04177368,0.01033825,0.032593157,0.0034869232,-0.060688697,-0.123601645,0.0021110072,-0.04458466,-0.017491028,0.0005479108,-0.03650753,0.022638746,-0.0006100519,0.020331005,0.017525366,-0.024345296,0.04038255,-0.02532832,-0.022411115,0.002416465,-0.014561619,0.002136337,-0.06833024,-0.03392692,-0.01836786,-0.041307386,0.09423219,0.0041773617,0.030741297,-0.032937113,-0.011905734,-0.008953592,0.003914178,0.09019357,0.010443231 +3.5.1.129,"The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides.",384,1.0,0.00086935156,0.028984573,-0.09856696,0.0005869564,0.040496964,0.05189975,0.040568266,0.035439532,0.087225884,0.06917126,0.042680837,-0.019494582,-0.0071491254,0.057452094,-0.019974787,0.004811077,-0.061425626,0.034169238,-0.028686112,-0.021539807,0.06917823,0.0103509575,0.047937796,-0.000493271,0.0043237237,-0.055889405,0.07686529,-0.022352364,-0.041124962,-0.025756212,-0.007620384,0.00246204,0.032421198,-0.059269976,0.063910976,0.08982122,0.02302803,-0.06664525,0.11036324,0.021164235,0.032886125,0.019212434,0.04443041,-0.024027742,-0.065925635,-0.0012164997,-0.016136149,0.07541367,0.030929375,-0.08978796,-0.09499366,-0.09178174,-0.03332389,-0.019023865,0.019813422,0.07926299,-0.015557064,-0.04241991,0.032004714,0.0015403631,-0.04878791,0.052604623,0.0979213,0.022182975,-0.014666444,-0.08363408,0.052344806,-0.084867395,0.0071961596,-0.004441503,-0.092125356,0.0024367566,-0.034881286,0.0013984918,0.01796247,-0.019820297,0.0030216437,0.057617825,0.033969846,-0.0016653613,-0.041049663,-0.05642494,0.06212653,0.019022139,-0.0740426,-0.031477127,0.042021062,0.022736654,0.12969102,0.050341588,0.008542363,-0.03938596,0.0111460695,-0.058485717,-0.09279579,-0.073520295,0.050935205,-0.013554468,0.101550885,0.016497774,0.0007195698,-0.033718318,0.015489503,-0.052775163,-0.037136286,0.0012893567,0.04752552,0.046612877,0.03926249,0.016196277,0.009094557,0.07933765,0.035812914,-0.056650214,-0.10862455,0.0468432,0.031221127,-0.07905195,-0.06991845,0.007072823,0.039457418,-0.0932451,0.05959174,0.018354546,-0.03100279,0.052780464,-0.12358785,1.5116789e-33,0.059316892,0.017443227,0.05577579,-0.036229443,0.06821,-0.026857285,-0.06813882,-0.042755164,-0.053993348,-0.053640835,-0.1034281,-0.06591326,-0.0062011518,0.036937837,0.033499375,0.010385579,-0.06263002,0.026734076,0.033278137,0.032603465,-0.037880816,-0.023960741,0.039384525,-0.030023819,0.0681689,0.077575184,-0.03348593,-0.004545251,0.03803486,-0.010036915,0.1360456,-0.040657658,-0.12886786,0.02304801,0.08798305,-0.0028538378,-0.02453907,-0.040573068,-0.0028339697,-0.026684197,0.010056977,0.06364645,0.0013233003,-0.006070069,0.0174713,-0.03528761,-0.058713563,0.09896001,0.07881588,0.09279138,-0.00637868,0.017420445,0.06690549,0.027129376,-0.053720538,0.05058442,-0.015705612,-0.042957913,0.038730048,0.025589332,0.012451426,0.046914488,-0.039674427,-0.0018929532,0.008872122,0.032624163,0.01427433,-0.02916109,0.07369245,0.009487189,-0.04939046,-0.05701944,-0.028163256,0.08694956,-0.064677104,-0.071753494,-0.02593728,-0.034573052,0.028284054,-0.021964395,0.052987583,-0.028199747,0.018397704,-0.023263887,-0.11125658,0.00122026,-0.059168674,-0.0031049398,-0.056068566,0.037991073,0.033418372,-0.04496366,-0.028025324,0.02765713,0.0006445875,-3.602013e-33,0.041080307,-0.07182004,0.039441496,-0.060497154,0.0053073554,-0.03969165,-0.009809185,-0.053340554,-0.020556912,-0.08369863,0.029933192,0.051886838,0.037113313,0.0040199384,-0.0032013354,0.036898326,-0.010366752,0.095042445,-0.053820886,0.003394699,-0.015469418,0.049988307,0.007899804,-0.07558472,0.036409725,-0.018989569,-0.012135237,0.11666174,-0.046831757,-0.0007665793,-0.0069269384,0.009594664,-0.056704257,-0.0844883,0.0029765337,-0.043114796,-0.079250544,-0.05655492,0.06090029,0.006331237,0.04532478,0.02055179,0.009707362,0.032842368,0.019967228,0.09747613,-0.088270284,0.009814146,0.0026687274,-0.026630087,-0.070104204,-0.025837231,0.00846017,-0.017338762,0.018244028,0.059420295,-0.0068820645,0.009893483,-0.03704261,-0.069067374,-0.015878458,-0.022306552,0.06595329,0.012721316,0.029341217,0.050781302,0.04436962,-0.018347818,0.075478256,-0.08086883,0.08442533,-0.016700028,-0.013300865,0.073079236,-0.055792563,-0.04036699,-0.13524964,0.018619047,-0.040684897,-0.00611526,0.028425891,-0.035226364,0.006199031,-0.07045707,0.029830834,0.0030948957,0.050188795,0.07215719,-0.008307731,0.03666079,-0.014569306,-0.03842219,-0.02032422,0.10464879,0.03858786,-3.2075445e-08,-0.0034860296,-0.10151801,-0.034875102,-0.07051639,-0.022359736,0.004883256,-0.029357491,-0.040785957,-0.01922413,-0.041875713,0.039773118,0.13311018,-0.0060937963,0.053019915,0.014482816,0.043314364,-0.104258135,0.027275598,-0.040036008,0.028597122,-0.095343925,0.024028108,-0.032682598,0.059782013,0.025446795,-0.032017045,-0.007890767,0.09344029,-0.041317303,-0.0132761495,0.041729283,0.08959863,0.00050424854,-0.008018789,-0.119777724,0.034455582,-0.08505848,-0.023015108,-0.006227993,0.054320604,0.058670986,-0.006330845,-0.074706234,0.00028922927,-0.004056461,0.06777663,-0.030937543,0.07951412,-0.075341135,0.0016213834,0.029248554,0.029264351,-0.07865119,0.010344326,-0.08677532,-0.017234735,0.0017644361,-0.008327801,0.02922169,-0.031426266,0.030024795,0.0056703757,0.12585841,-0.1039741 +4.1.1.113,"The enzyme, characterized from the smut fungus Ustilago maydis, is involved in an alternative pathway for the biosynthesis of itaconate. cf. EC 4.1.1.6, cis-aconitate decarboxylase.",384,1.0,-0.035950642,0.047169223,-0.117756575,0.0030453186,0.035026856,-0.00052779814,-0.089885935,0.027779438,0.021055512,0.04432254,0.04306219,-0.06829255,-0.05260509,-0.02600547,-0.09526891,0.02020953,0.0027576818,0.040928744,0.0068209143,-0.076324515,0.04305191,0.04502247,-0.034381792,-0.029098772,0.032122757,-0.04852446,0.0076054684,-0.017121172,-0.06737667,-0.08963685,-0.032869104,-0.035231344,0.04905817,-0.016110871,-0.03447305,0.06022004,-0.016919198,-0.0341861,0.07928228,-0.028513057,-0.0009967429,-0.02813794,0.014522151,0.009457683,-0.058734484,0.010934485,-0.109784506,0.0023445575,-0.047596123,0.010335045,-0.052574214,0.041745014,0.0128032835,-0.05028593,-0.010131432,-0.009952905,0.024959242,-0.012648286,-0.06479678,0.01731745,0.049987637,-0.051648792,-0.016548067,-0.0038166668,-0.021181842,-0.06697388,0.039909583,-0.015568209,0.024570072,-0.060578506,-0.069899105,-0.070126414,0.0016430878,0.010105849,0.055707492,0.05473963,-0.015354179,0.0030317793,0.033988263,0.0020135434,0.024994886,0.10936701,0.0063410928,-0.025511932,-0.022211315,-0.011056878,0.0030798188,0.01416379,0.050994053,0.075894736,0.081779435,-0.014079906,-0.029645793,0.045597967,-0.043314956,0.03317774,0.043997623,0.007994277,-0.0190381,-0.05179274,0.02700062,0.06360857,-0.06986059,-0.14104739,-0.09610997,-0.024520705,-0.014388264,-0.023774944,0.071344666,0.03311734,-0.015637452,-0.025606003,-0.016586794,0.014558626,0.04477594,0.012758806,0.0045951647,-0.052098528,0.005520096,-0.018997489,-0.04332838,-0.013036019,-0.04981902,0.08059334,-0.04386903,-0.023714531,-0.07699835,-1.297687e-33,0.051298305,0.048440035,-0.018121837,0.007608873,0.046633493,-0.00025175855,-0.030614085,0.04605091,-0.09173794,-0.05964972,-0.1072722,-0.090065606,-0.033520248,0.01433021,-0.06027629,-0.046994973,0.029060563,-0.041915946,0.03808831,0.017318994,0.007153266,0.09982144,-0.097523905,0.016524022,0.046917517,0.1373786,0.006056065,0.0012208031,0.039982796,0.029023675,0.00901582,-0.06426152,-0.06360335,0.026506541,0.12589534,0.04213289,0.008977497,0.000610012,-0.05332042,0.078939885,0.045977924,0.062678695,-0.022610947,-0.022264358,0.08791825,0.00041258679,0.03368557,0.12638235,0.009572613,0.0066313874,-0.026804248,0.05295814,0.105309606,0.011331567,-0.035922688,0.066124484,-0.092600755,0.023050705,0.044339247,-0.04448262,-0.048946176,0.069538675,-0.042776734,0.048265208,0.013831667,0.024783982,-0.11799408,-0.041895892,-0.0172866,0.0729292,-0.054658167,-0.008208454,-0.036326703,0.016073829,0.02273596,-0.050606348,-0.020132022,0.036928177,-0.035636578,-0.032240532,0.018583775,0.027677402,-0.041928843,-0.06971515,-0.017254265,0.0076642763,0.00097083126,0.05149054,-0.007955549,0.061768185,0.042070825,-0.04427773,-0.046087835,0.090932965,0.08875039,-1.5698918e-33,0.09726672,-0.12428633,0.063291416,0.012918577,-0.001301316,0.06918354,-0.024413671,0.025586989,-0.034990367,-0.034762386,0.041849732,-0.039120466,0.056637675,-0.03737792,0.004037617,-0.008635222,0.043913744,0.10857285,0.012730853,0.048916742,-0.07436813,0.07354939,0.0025063627,-0.030229477,0.03238387,0.04278624,0.030521423,0.06884855,-0.021480877,0.017144771,0.04290662,0.009047062,-0.031218845,-0.06423425,-0.067351505,0.057602387,-0.07947138,0.006293431,0.022131814,0.06431233,-0.031598125,0.0071334993,0.022109546,0.06966633,0.046094265,0.03195153,-0.10160946,0.065986715,0.03320477,-0.09794118,0.033045623,0.0069822604,0.007308984,-0.028189806,0.07235211,0.015255591,0.03702874,0.0060081957,-0.00227955,-0.030384954,-0.07418892,-0.037138063,0.04307422,-0.0062029557,0.11708304,0.04792043,-0.018366149,0.0058260127,0.06447871,-0.04248471,0.11096388,-0.0048936415,-0.027836824,-0.025552908,-0.01400452,-0.009585389,-0.09757567,-0.012253712,-0.01885199,0.084186874,-0.035265014,-0.037379783,0.06698464,-0.047155727,-0.042968813,-0.08795058,0.06922815,0.088698365,-0.0750522,0.06979608,-0.04271652,0.010801585,-0.06913228,0.015670605,0.037601616,-3.154315e-08,0.054219436,-0.09642651,0.018276263,-0.040100597,-0.014199068,0.04635074,-0.0005142342,0.017831227,0.01897273,-0.01296636,0.004501555,0.0076413415,0.0023513467,0.059108444,0.11336758,-0.022425592,0.024408061,0.051071845,-0.013081395,0.06400135,-0.07617903,-0.053989556,-0.058489785,-0.0006456127,-0.002960118,-0.011991597,0.13060516,0.014256846,0.062224306,-0.03633939,-0.062438924,-0.027038408,0.016727854,-0.021176565,-0.13219705,0.022452353,-0.026313633,-0.08443759,0.055904035,-0.026724217,0.063994035,-0.045970242,-0.022437068,0.05210446,-0.07815937,-0.031891014,0.059969313,0.002648576,-0.088360034,-0.040956832,-0.075608514,-0.0029739821,-0.00507154,-0.02385029,-0.0280703,0.020825244,0.04005137,-0.013085748,-0.04433429,-0.057414986,-0.042385526,0.008192152,0.14107592,-0.008786733 +5.1.3.42,"The enzyme, characterized from the archaeon Sulfolobus tokodaii, participates in a pathway for the biosynthesis of UDP-N-acetyl-alpha-D-galactosamine.",384,1.0,-0.06517939,-0.06270007,-0.11577614,-0.025634866,0.025803722,0.019824395,-0.047926776,-0.0012082468,-0.014084711,0.026519733,-0.009754125,-0.028014362,-0.08136193,0.01694425,-0.12732428,0.06800473,-0.03823867,0.008893529,0.058061976,0.006767773,0.111149974,0.00061385013,-0.019292897,0.043497916,0.037686173,0.007892337,0.0512426,-0.079200596,-0.0751819,-0.084399484,-0.0151620535,-0.0067192046,0.09719698,-0.05904888,0.043150567,0.1323226,0.003811413,-0.017224815,0.01572608,-0.02263065,0.049860474,-0.015278386,-0.0052513126,-0.05637641,-0.02989152,-0.009461848,-0.064402476,0.044130754,0.07445381,-0.027730513,-0.022739073,-0.04892149,-0.046193562,0.011624573,0.044342306,0.08128805,-0.002055316,-0.041203175,0.011335719,-0.023028163,0.055431027,0.06686145,0.005920519,-0.0031264743,0.009648146,-0.047408618,0.016953114,-0.07065315,-0.0360761,0.015512873,-0.046136566,-0.0396996,-0.048306804,0.0045730383,-0.035933785,0.07168502,0.016736247,-0.04666522,0.06374432,-0.05955643,0.026981913,0.036789406,0.00012811658,0.043813065,-0.0066287564,-0.011415915,0.0740371,0.004482688,0.06829507,0.036808215,0.0032278143,-0.052067697,-0.013979593,-0.058878046,-0.06602324,-0.021376954,0.054888517,0.02587353,0.0007084914,-0.019539949,0.030244727,-0.014668424,-0.022710292,-0.16635923,-0.06261206,0.010194987,-0.021245575,-0.010758694,0.11457554,0.06833151,-0.033058617,-0.032494243,0.031953562,0.03853889,-0.057511006,0.12213117,-0.04803342,-0.06951515,-0.08808354,0.025112715,0.02653965,-0.048214126,0.03505875,0.08130371,-0.0016054723,0.019348392,-0.059409477,-1.3785179e-33,0.11978699,0.040714957,0.007949376,-0.0432682,0.014017374,-0.03195806,-0.066622734,-0.02688485,-0.014023982,-0.039818604,-0.11953266,-0.02642893,0.03633766,0.054072205,-0.037546553,0.083818786,0.016035287,-0.007833579,0.01832929,0.008488497,-0.0680808,0.059753414,-0.1218184,-0.0045450046,0.040510856,0.028563032,-0.032957233,0.016117288,0.037360996,0.040498972,0.014013078,-0.11506731,-0.09498769,0.06556869,0.03983779,-0.0015459366,0.044202928,-0.08436606,-0.025283886,-0.04703057,0.038692348,-0.013691002,-0.0040153745,0.029919328,0.0008882545,0.0034409408,-0.020523947,0.008223048,0.045840304,0.021114258,-0.05053714,-0.041637067,0.08756777,-0.0041327407,-0.04462811,0.02841753,-0.08566556,-0.02979514,0.07049697,0.067398325,-0.011033196,0.03543682,0.008375575,0.06878604,-0.028020049,0.006342585,-0.015848003,-0.005857246,0.061695773,-0.023375718,-0.07440583,-0.06242563,0.01925079,0.03550509,-0.051894035,-0.02216283,0.046174698,0.025266837,0.022770979,0.011681677,-0.0575679,-0.0193519,-0.029556036,0.011106295,0.008674328,0.05316762,0.009623471,0.023292115,-0.033514827,0.045158118,-0.014399384,-0.06258912,-0.068779126,0.08040119,0.03481233,-1.7999223e-33,0.070032075,-0.10274152,0.03332326,-0.07601427,-0.08315816,0.10197418,0.042383246,-0.014489385,0.021080574,-0.06353925,0.025332643,-0.041682884,0.017709611,-0.072839014,0.046144903,0.0023615512,0.07553182,0.10223228,-0.045339003,0.020158574,0.008867362,0.076985955,-0.037925392,-0.00033649578,-0.013491332,-0.004802263,0.0071596666,0.057210505,-0.028211473,0.081906885,0.034448706,0.034154125,-0.07130291,-0.07655719,-0.011767373,0.009382269,0.015724203,-0.0022097747,-0.02093933,0.031057108,-0.026945759,0.06942271,-0.009834414,0.048288442,0.06929162,0.023126278,-0.07245137,-0.0038834193,0.039252207,-0.05774271,0.07827746,-0.04335919,0.09031978,0.027194584,-0.01485829,0.024426762,0.007580054,0.07191806,-0.01566087,-0.0072646597,-0.05688475,-0.038436692,0.04134744,-0.06667206,0.008424778,0.07622254,-0.00882283,-0.020725196,0.0031464302,-0.05719073,0.027498225,-0.026851248,0.031731654,0.15165952,-0.038285207,-0.033180397,-0.09902401,-0.012871793,0.032628164,-0.03401171,-0.019585354,0.06376341,0.033102356,-0.06174196,-0.019175742,-0.05107153,0.110966556,0.105596,-0.010061718,-0.0068083922,-0.013479716,-0.010240894,-0.11114208,0.03457931,0.049228642,-3.405439e-08,0.06755535,0.012055024,0.057665568,-0.049759295,-0.029822895,0.017531555,0.04608963,0.029603448,0.056617353,-0.07685717,0.012092851,0.13338172,0.04561407,0.053444296,0.06773983,0.047968917,0.021449404,0.028464224,-0.021226928,-0.00779033,-0.005275811,-0.057090137,-0.07037826,-0.013655898,-0.022566564,-0.053972628,0.0792137,0.030595906,-0.0030420704,-0.05905259,-0.014236401,0.025892865,-0.05236026,-0.05166021,-0.01669636,0.10913089,-0.042385858,-0.09447418,0.063954294,0.028466852,-0.013180888,-0.025912026,0.01705324,-0.004254587,-0.039151426,-0.0010471982,0.019522548,0.04546875,-0.0332802,-0.0016801147,-0.0392711,-0.0052401572,-0.04271412,-0.14645451,-0.039769128,-0.051328562,0.03217615,-0.08387626,-0.015887024,-0.0276125,0.052184608,-0.026998095,0.089629665,-0.041304007 +5.4.2.13,"The enzyme, characterized from the archaeon Sulfolobus tokodaii, is also active toward D-glucosamine 6-phosphate (cf. EC 5.4.2.10, phosphoglucosamine mutase).",384,1.0,-0.0611856,-0.086796016,-0.12105502,-0.08081914,0.010842256,0.007987982,-0.034527067,0.013242047,0.040857174,0.052124638,0.0018829112,0.033243295,-0.08097299,0.09652032,-0.087900326,0.08318718,-0.03000451,0.009074031,-0.0036971911,0.032289464,0.109820075,0.055362433,0.003876243,0.0035335966,0.058508698,0.0060748253,0.03768929,-0.015796771,-0.052905913,-0.015832674,-0.08311786,0.058825027,0.04058229,-0.021406835,0.042207744,0.12905072,-0.0694559,-0.059122555,0.023534024,-0.0028240194,0.021637794,-0.011570527,0.025249017,-0.103250034,-0.059219763,-0.0124948695,-0.044431314,0.050675496,0.075303584,-0.016307909,-0.02417609,-0.092360266,-0.00034656897,0.004834165,0.050166074,0.020884937,-0.08624922,0.03422457,-0.021188602,-0.021997133,0.014080567,0.06213897,0.03164364,0.033159647,0.016854785,-0.028408136,0.03390814,-0.07001034,-0.056684494,-0.040431798,-0.05131789,-0.03468128,0.048947416,-0.012617392,-0.023168037,0.051428944,-0.009496826,-0.026888246,0.040964905,-0.0988168,0.054082185,0.0017733345,0.031127604,0.066839345,-0.007238426,0.016310224,0.0020307112,0.038382553,0.053313598,-0.043980163,0.05172842,-0.05544793,-0.06181474,-0.10542366,-0.049031142,-0.0068649584,-0.044512883,0.07453987,-0.049561445,-0.010694485,0.024746018,0.02809908,-0.031712737,-0.12443666,-0.048437566,0.0006247085,0.006818862,0.06731988,0.0445091,0.016955445,-0.034109876,0.013174567,0.033555098,0.059984867,-0.041767642,0.08333553,0.0037759657,-0.043742288,-0.10928241,0.023855582,0.03487292,-0.046534345,0.025071668,0.07406389,-0.04238127,0.015396934,-0.06419271,6.0606464e-34,0.12114664,0.029813128,0.05067993,-0.06986425,-0.0196943,-0.03843853,-0.06142018,0.010855091,-0.06100368,-0.022614239,-0.13164315,0.023860786,0.053372715,0.054867197,0.0026718958,0.06390657,0.02477185,0.010958625,0.07499252,0.005731586,0.07449229,0.07378927,-0.0894557,0.006523858,0.0063841953,0.06993724,0.0040307664,-0.0056368285,-0.015915286,0.013344402,0.0038567462,-0.14652887,-0.050248772,0.059754606,-0.0036450722,-0.010410747,-0.076197475,-0.020968799,-0.04845666,-0.02040927,0.050788853,-0.04052148,-0.029371731,0.008436559,0.033514924,-0.042335615,-0.03230194,0.023185197,0.026104363,0.085199445,-0.014831689,-0.044756077,0.07495425,-0.0487759,-0.09725456,0.006117162,-0.0021997718,-0.036428854,0.06841304,0.06470437,-0.020939408,-0.025317615,-0.057535153,0.017839732,-0.02715569,0.016850531,-0.04286492,-0.06677897,-0.010778494,0.061249487,-0.038458932,-0.07364017,-0.035409924,0.07993944,-0.037451267,-0.017261876,0.037695464,-0.00021215918,-0.024117252,0.013046999,0.026750285,-0.061553206,-0.033620037,0.06667006,-0.076954536,0.03991246,0.0016947142,-0.029420502,-0.03408277,0.04628551,-0.014983456,-0.10583573,-0.10154533,0.029508699,0.039093614,-2.6726561e-33,0.10383576,-0.061238084,0.033673026,-0.07593255,-0.04628655,0.09637864,0.10168944,-0.008570282,0.03186088,-0.055376075,0.06736425,-0.007826586,-0.006227881,-0.031156957,-0.0025979306,0.081353396,0.03130835,0.06617753,-0.01257576,-0.0020048341,0.003976181,0.086151436,0.008152898,-0.0046926904,0.03595728,0.011076878,0.04652976,0.041930605,-0.05040099,0.075805694,-0.04477245,-0.0037184695,-0.008969625,-0.047420688,-0.0075163827,0.029179668,-0.02376266,-0.047411136,-0.032955803,0.016587295,-0.008112248,0.082785755,0.06099945,0.08249365,0.03657509,0.03867167,-0.088667646,0.004764474,-0.028781908,-0.03799652,0.03728763,0.01182087,0.10012017,-0.016765501,0.06777354,0.023103464,0.010557937,-0.0003329121,-0.11685508,0.01198873,-0.068283804,-0.024803031,0.0019126092,-0.02765142,0.028043127,0.0922452,-0.0038027,-0.0026029693,-0.03442322,-0.01956661,0.043911763,-0.06765872,0.031116294,0.09016662,-0.07616842,-0.07583793,-0.06749285,0.027415285,0.067656934,-0.019282522,-0.02542892,0.005631754,0.013174578,-0.027557336,0.044508316,-0.05539607,0.07144331,0.082886234,0.04753556,0.017756827,-0.018103138,0.016958933,-0.06811022,0.0055036917,0.058618348,-3.8002966e-08,0.062085293,-0.049705576,0.03408166,-0.037297588,0.019552326,0.0003249124,0.0864941,0.05290489,-0.0057335524,-0.026012436,0.02703043,0.09262213,0.035484117,-0.0106563065,0.05713594,0.027026817,-0.017796634,0.005692746,-0.03196727,-0.01875435,0.013545863,-0.058665078,-0.0753926,-0.0056998627,0.036584478,-0.019918883,0.009695495,0.00014922065,-0.014539322,0.00011470272,0.0036663695,0.04007753,-0.077451326,-0.060562402,-0.048664644,0.087961756,-0.05620095,-0.03984272,-0.06269347,0.030915027,-0.011514837,-0.010412311,0.0029604717,0.027364425,0.018419048,0.02000385,0.01036666,0.03828366,0.030576577,-0.0020557477,0.0064945696,0.007520436,-0.020134896,-0.11479327,-0.12928268,-0.034392003,0.041071538,-0.0926949,-0.008856312,-0.066784516,0.093540505,4.2730673e-05,0.13966872,-0.04096998 +7.1.1.3,"Contains a dinuclear centre comprising heme and copper. This terminal oxidase enzyme generates proton motive force by two mechanisms: (1) transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water, and (2) active pumping of protons across the membrane. The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) of enzymes that have been characterized so far is 2. cf. EC 7.1.1.7, ubiquinol oxidase ubiquinol oxidase (electrogenic, proton-motive force generating).",384,1.0,-0.05906518,0.0042394996,-0.109988555,0.080804944,0.09778609,0.0165105,-0.017350301,0.012127302,-0.0023063659,-0.063415535,-0.0012477771,-0.08157273,-0.017478269,-0.0071098106,-0.04857092,-0.024544807,-0.05328539,-0.032617543,-0.07711144,-0.07880237,0.050076153,-0.0392848,0.08132079,-0.050167568,-0.039220992,-0.03710315,0.046347618,0.026694393,-0.013580902,-0.09863366,0.103190154,-0.058313,0.03430074,-0.06727954,-0.0036037334,0.0511589,-0.028830826,-0.028170917,0.019732293,0.035472244,0.037897844,-0.06455168,0.015695076,0.04571803,0.00085611973,0.023067145,0.02321932,0.00824839,0.029615171,0.024017522,-0.024385052,-0.048350193,-0.0023672963,-0.031386014,0.012006414,0.030354613,0.0069960696,0.02811053,0.008754942,-0.05008149,0.042817835,0.034666047,-0.0072142314,0.012178178,-0.013427278,-0.043061767,0.029806113,-0.051181123,0.046002433,-0.029813899,-0.00838821,-0.09370158,-0.08726547,-0.054799695,-0.04454078,0.040741164,-0.0076143625,-0.020091146,0.045157686,-0.019137578,5.0994346e-05,0.010752206,-0.0035644006,0.07843231,0.026389506,0.027097054,0.06476818,-0.12267784,0.016018178,0.011644556,0.013855887,-0.020103944,-0.06079529,0.012955517,-0.092569225,0.018992214,0.063442566,0.05170665,-0.0384848,0.0005578363,0.01694258,0.15439562,-0.03518508,-0.08510485,-0.0259284,0.0047435877,-0.011764546,0.10254305,0.089259885,0.045087412,0.025145544,-0.018710073,-0.016816074,-0.0005604592,0.030231018,0.062401403,0.00851156,-0.005299062,-0.010257041,0.046016403,0.012030525,-0.0013619403,-0.009584477,0.037129298,-0.004830112,-0.121249616,-0.12105553,2.9443454e-33,0.037286695,-0.04411832,0.0029017346,-0.05107181,-0.023141766,-0.058510832,-0.06829117,0.04546085,-0.038855504,0.04262823,-0.06812304,-0.018339982,0.060233004,0.034404352,-0.010560778,-0.08770366,-0.054057598,-0.035750203,-0.038057167,0.083289444,0.0025420522,0.006380003,-0.016864704,-0.033067785,0.083644845,-0.02331311,-0.05758098,0.01647059,0.034580924,-0.0021375632,0.012286375,-0.06924594,-0.05109399,0.023640266,-0.06502523,0.010106227,-0.05863079,0.0013205908,0.049989767,0.049173392,0.008701732,0.049441535,0.021383507,-0.060179736,0.10925742,-0.025044642,-0.040055916,0.11147236,0.019722925,0.018129075,0.03292574,-0.033843853,0.14136054,0.019382672,-0.0011009952,-0.009041152,-0.047474217,0.07287012,0.076614186,0.052421477,0.006604195,0.08367599,-0.06779658,0.0070158336,0.02536049,0.051131815,-0.027051207,-0.009793893,0.0063745286,0.08699757,-0.09608363,0.02097485,-0.024972497,-0.046625815,-0.010462907,-0.02662654,-0.06817121,-0.027310973,0.084701054,0.030366685,-0.029143402,0.025310721,0.038308438,-0.022033283,-0.003378117,-0.003737606,-0.009332214,-0.0010440795,-0.04584638,0.03253913,0.07549276,-0.054640558,0.011106375,-0.08046286,0.06335134,-4.2580343e-33,0.06605076,-0.0019752004,-0.047714796,-0.06144069,0.047958016,0.019420793,-0.04392031,-0.018425459,-0.011194324,-0.017265555,0.05872983,0.008423357,0.028287273,-0.033555508,0.016382158,-0.01669032,-0.058776204,0.12548707,0.04935174,0.015384385,0.041624356,0.09559358,0.008194578,-0.032322325,0.077825524,-0.027419161,-0.058934685,-0.02413541,0.0656817,0.08385861,-0.069385566,0.032246254,-0.03032912,0.032144487,-0.07976664,0.03679425,-0.09897776,0.06768351,0.09178872,0.06516918,-0.0025905615,0.007446336,0.029835409,0.037115432,0.0077771307,0.113244295,-0.10255775,0.025362825,-0.041607305,-0.023798047,0.07610214,0.007977421,-0.085652545,-0.00974984,0.00044890618,0.045179036,0.019219905,-0.020973567,0.012067705,-0.071911044,-0.030347316,-0.0012084693,0.015736613,0.004649249,-0.043987803,0.06741132,0.02665132,0.12338794,-0.014117318,-0.041553337,0.07005421,0.037984546,0.03285135,0.01730691,-0.026813438,-0.037186418,-0.03502482,-0.01900776,-0.030821834,-0.0009784473,-0.0050896206,0.046764113,0.0067971842,-0.113469,0.023350336,-0.031953547,-0.023891529,0.0589671,0.013281163,0.044821907,0.0047446345,-0.030431835,0.0059515913,0.067892976,0.036393933,-4.462228e-08,0.03846416,-0.06962118,0.03902905,-0.033804387,0.057011534,0.042284634,0.021272307,0.01275985,0.015489468,-0.024140669,0.016949728,0.08622086,-0.029764215,0.017544795,0.08028849,0.053962655,0.038767114,0.06170487,-0.023681443,-0.08265914,-0.03155546,-0.012232382,-0.15007049,0.028617328,0.054915972,-0.03807725,0.050665602,-0.0006038102,-0.07234175,-0.05968752,0.03535648,0.016962714,-0.04249719,-0.018366536,-0.043300238,0.04570581,-0.07340054,-0.0367842,-0.03302323,-0.0010678523,-0.0761633,-0.042901028,-0.056701522,-0.010530667,-0.012726841,0.014980706,0.016306393,0.038576555,-0.034577366,-0.03032477,0.014005284,-0.07114231,0.058155123,-0.10774996,-0.06347411,0.13109183,-0.05018512,-0.08713316,-0.015294953,-0.10530837,0.03829961,0.031957436,0.1685588,-0.0286933 +7.1.1.4,"A copper-containing cytochrome. The enzyme from thermophilic archaea is part of the terminal oxidase and catalyses the reduction of O2 to water, accompanied by the extrusion of protons across the cytoplasmic membrane. 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+7.1.1.5,"Cytochrome aa3-600, one of the principal respiratory oxidases from Bacillus subtilis, is a member of the heme-copper superfamily of oxygen reductases, and is a close homologue of the cytochrome bo3 ubiquinol oxidase from Escherichia coli, but uses menaquinol instead of ubiquinol as a substrate.The enzyme also pumps protons across the membrane bilayer, generating a proton motive force.",384,1.0,-0.124455884,-0.024519974,-0.12508681,0.003930614,0.0013990733,0.0044229575,-0.021120004,0.022569466,0.009669056,-0.057879876,0.012168611,-0.042629655,0.028529951,0.025233228,-0.028986532,0.040033054,-0.061574556,-0.017906077,-0.04424927,-0.020109069,0.035140216,0.08210439,0.048593737,-0.010604252,-0.01949834,-0.038030174,0.051469173,-0.0051430883,-0.072150305,-0.029201277,0.023919007,-0.043115534,0.0698301,-0.064206816,0.06634996,0.055441737,-0.034113176,-0.015781775,0.016713332,-0.012120142,0.006103167,0.051745255,-0.002271776,0.10091677,-0.011113673,0.016344432,0.005942628,0.016661556,0.09358399,-0.019447032,0.0044961236,-0.038671955,-0.03590066,0.058973607,0.04707661,0.025851216,-0.07448205,-0.055034135,0.025934683,-0.041458063,-0.017372139,0.028737642,0.042094246,0.02033043,0.023125453,-0.010191402,-0.047169697,-0.0652068,-0.022527255,-0.03265409,-0.062153533,-0.090107694,-0.07829227,-0.006269814,-0.068516225,0.08703589,0.036039818,-0.064395584,0.021387959,-0.048908114,-0.002309907,-0.07612029,-0.0005756811,0.18598366,0.08030834,0.0001652528,0.026390674,-0.094375506,-0.063249886,0.0126775745,-0.029844856,-0.011861482,0.0016498445,-0.0486199,-0.06864941,-0.03963758,0.04412448,0.12765208,-0.027979257,-0.0020311542,0.044754073,0.12701122,0.0076177665,-0.07155397,-0.051198367,-0.050243344,0.016882814,0.109243825,0.08921263,-0.0018804793,0.0018845212,-0.02745665,-0.029570382,-0.08503518,0.026781479,0.033618737,0.021247935,-0.031257663,-0.10055002,0.023657057,-0.037326165,0.015520158,-0.010765331,-0.038993664,0.005278161,-0.09571641,-0.12240724,4.9065454e-33,0.025914328,0.016429992,0.024831057,0.02484883,-0.010354428,-0.044250097,-0.08087075,-0.02073795,-0.008738819,-0.015326676,-0.08185359,-0.0076958584,0.011587102,0.011351602,-0.0017820016,0.021359196,-0.058154978,-0.038148046,0.035616297,0.011091188,0.015208476,-0.029117564,0.008823768,-0.06883365,0.020757254,0.025902824,-0.013390782,-0.020638926,0.006972839,0.015796922,0.045370065,-0.047591846,-0.11465653,-0.034516033,-0.033359796,-0.0325262,-0.037687305,0.00065187336,-0.06966786,0.089842044,-0.056785714,0.035324797,-0.021123454,-0.03342828,0.1280092,-0.04603279,-0.06555592,0.1420387,0.015869899,0.07822387,0.039276544,-0.04727452,0.12912169,-0.013597302,-0.005897928,-0.0064387433,0.013136122,0.072413005,0.0048105763,0.044201892,0.08076597,0.090037234,-0.06633562,0.12072959,-0.020142026,0.06650549,-0.028883088,-0.027194194,-0.014328003,0.10282051,-0.03017147,0.032722615,0.01678781,-0.02636298,-0.04024468,0.028305264,-0.06352726,0.0021281403,0.05185704,0.025667617,0.015044518,-0.05897466,0.03069435,-0.023580732,-0.046381008,-0.035669927,0.013208531,0.0027122633,-0.06379534,0.051501665,0.08883472,-0.093544126,-0.016283682,-0.025708266,0.0071525713,-4.935378e-33,0.09445873,-0.052234072,0.014590795,-0.16589186,-0.012217175,0.026922017,0.018311275,0.008147895,0.0024061669,-0.006107896,0.048828132,0.023428096,0.026567912,0.0022277453,0.039631423,-0.046009842,-0.04355798,0.03766704,0.018452497,-0.00092737493,0.023601947,0.05699514,0.01593083,-0.035950176,0.02007501,0.025156546,-0.036878996,0.033342384,0.083658926,-0.029092444,-0.07399382,0.056642726,0.007952705,0.0040654154,-0.062371504,0.08013075,-0.016940787,0.028843576,0.055389,-0.0016016647,-0.012049867,0.064624146,-0.01601253,0.045481436,0.03346345,0.14896846,-0.09113926,-0.010172906,-0.034094617,-0.029056218,0.05025105,-0.027470607,-0.039492495,-0.008171082,0.061037757,0.0669777,-0.048588324,-0.029262157,-0.017388396,-0.046028044,-0.032676984,-0.0020964732,0.017154321,0.038519174,-0.080696926,0.092000514,0.04220272,0.048498534,0.0121416785,-0.044187944,0.03821549,-0.009823317,0.015827168,0.021812389,-0.018497149,-0.012219213,-0.0067811185,0.04537603,0.03998372,0.031773355,-0.056180283,0.004393992,-0.03564878,0.01217809,0.056068867,-0.04703575,-0.06467953,0.10411738,0.013894306,-0.04628365,-0.020726355,0.019973092,0.027276376,0.06025735,0.014137631,-3.9484284e-08,0.058596008,-0.03405556,0.11135263,-0.020789005,0.060702946,0.047855485,0.018404424,0.007474705,0.023706745,-0.011401975,0.056322385,0.07130882,0.00045357173,-0.037206136,0.076279655,0.060928266,0.0061736484,-0.054306805,0.03253454,-0.06173567,-0.0589967,0.013704172,-0.083685115,0.07393442,0.021164296,-0.08357284,-0.0071188947,-0.019499663,-0.0640539,-0.014078193,0.004618987,0.04584201,-0.039892886,-0.052473594,-0.063619815,-0.038652565,-0.028818779,-0.02536959,0.003460874,0.015903845,-0.03465151,-0.042265587,-0.065311976,0.0041927546,0.039656255,0.019673282,0.0060623963,0.052261684,-0.024997959,-0.04795955,-0.02774318,-0.06145611,0.037022468,-0.05503575,-0.099091366,0.08248049,0.028088065,-0.086267434,-0.026359988,-0.05024114,0.049981203,0.0028181104,0.12793443,0.0003311198 +7.1.1.6,"Contains two b-type cytochromes, two c-type cytochromes (cn and f), and a [2Fe-2S] Rieske cluster. The enzyme plays a key role in photosynthesis, transferring electrons from photosystem II (EC 1.10.3.9) to photosystem I (EC 1.97.1.12). Cytochrome c-552 can act as acceptor instead of plastocyanin, but more slowly. In chloroplasts, protons are translocated through the thylakoid membrane from the stroma to the lumen. The mechanism occurs through the Q cycle as in EC 7.1.1.8, quinol---cytochrome-c reductase (complex III) and involves electron bifurcation.",384,0.99999994,-0.13475642,0.015012474,-0.106637076,0.0063825673,0.06236664,-0.015591943,-0.021265296,0.06709179,0.04531774,-0.0151270265,0.048536636,-0.019733267,0.024404388,-0.0005549635,0.023756042,0.07072679,-0.1444415,0.0048596584,-0.011182444,-0.047884036,-0.010515665,-0.1188225,-0.025948625,-0.053839806,-0.0015364595,0.022122057,-0.03557428,-0.0063082385,-0.06435959,-0.0770313,-0.045698285,-0.012554708,-0.019667666,0.048732996,0.024122735,0.12642197,-0.057071056,-0.12631217,-0.017805051,-0.029953986,0.0037566228,0.034118034,-0.040076416,0.016149836,0.0018483852,-0.024381213,0.0043932963,0.020754598,-0.035436187,-0.09760827,0.02784403,-0.009101581,-0.036769092,0.07246908,0.007311292,0.06398592,-0.029301222,0.017136537,0.023415817,0.017154418,0.0096411165,-0.009087923,0.023110187,0.026206754,0.013818852,-0.067772076,0.00014125711,-0.053968694,0.04527975,-0.114972636,-0.05254611,-0.022249604,-0.016566778,-0.04629779,0.041507196,-0.007155985,0.015264691,0.040782023,-0.03604318,-0.034288444,-0.016158769,-0.011696985,0.0005694516,0.057333566,0.06700156,-0.025951417,-0.010914371,-0.016691018,-0.070061006,0.028958272,0.0302897,0.018595658,-0.001174612,-0.02432191,-0.064581595,0.08261728,0.06460548,0.0008212178,0.05668327,-0.03471969,0.064243324,0.08624411,-0.01020777,-0.076248586,0.0212505,-0.051368747,-0.027430082,0.1144671,-0.05678863,-0.044754967,0.0035026853,0.020919077,0.028169809,-0.011867632,-0.010973022,0.07109143,0.058669224,0.040375162,-0.0033094583,0.031513378,-0.041853305,0.005397496,-0.077221125,-0.01955228,-0.02894393,-0.028913282,-0.13307348,2.3309002e-33,0.043232758,-0.017949825,0.036715344,-0.00027495014,-0.057787474,0.0037690015,-0.0822938,-0.02508354,-0.07238693,-0.08560443,-0.052798018,-0.08690225,0.036615808,-0.05811382,-0.01989297,-0.03885975,-0.03544278,-0.01519555,0.0039965464,0.016223261,0.04304626,0.029902084,-0.053537164,-0.04157283,0.06413188,0.066720285,0.020213254,-0.008202449,0.0356761,-0.008392742,0.009511312,-0.014741999,-0.07369347,0.053742256,0.07718172,0.005159038,-0.0244925,0.022046035,-0.011881145,0.015326579,-0.07760885,-0.0028373539,-0.03605618,-0.013005286,0.060834803,-0.004729736,-0.02956422,0.048864495,0.06833337,0.03230847,0.00016522034,-0.09372209,0.05901026,0.016721394,-0.015071755,0.006897184,0.087575555,-0.054560598,-0.022348749,0.057808917,0.10541968,0.0731662,-0.04754754,0.029107304,0.044788223,0.087683424,-0.10134661,-0.003371987,-0.038454376,0.10436229,-0.055454843,-0.035684865,0.052729543,5.5369692e-05,0.1097298,0.009051507,-0.05550448,-0.010709914,0.01552802,0.08105232,0.030519191,-0.034083173,0.04632406,-0.045923494,-0.05175335,-0.081792444,0.004229943,-0.07523876,-0.0010267156,0.08075888,0.076009765,-0.028452907,0.034450524,-0.023595724,-0.0074333656,-3.649641e-33,0.08234823,-0.028852774,0.03920145,-0.06820053,-0.0047574383,0.05492444,-0.07732593,-0.04381608,0.01648485,0.037575934,0.070895486,0.01169902,-0.06621228,0.03996786,-0.017218558,-0.03333537,0.011503785,0.055927616,-0.013190165,0.053429306,-0.04188264,0.023259146,0.07487006,0.00014420543,0.0657458,0.0028278779,0.00054804404,-0.0033128103,0.0735658,0.00075222395,-0.09430654,-0.0493993,-0.031876285,0.022412604,0.014791175,0.00245099,-0.086983785,-0.008665806,0.026615916,0.047454372,-0.04075625,-0.06061745,0.03357813,0.017913586,0.01275345,0.03705833,-0.07909484,0.04106402,-0.05084936,-0.0033280312,0.0021349867,0.04646808,-0.03548591,0.08343527,0.036015034,0.06106355,0.0046478617,0.03333757,0.036816567,-0.048326284,-0.024566252,-0.1360661,-0.04271471,-0.008702451,0.021571863,-0.03363312,0.013530872,0.0423984,0.008579457,-0.017643383,0.055815328,0.024474716,0.070307456,0.011029219,-0.038943402,-0.04036867,-0.01290024,-0.024414381,0.02181301,-0.052245855,0.01893481,0.014798148,0.0050321543,-0.04024844,-0.00934187,-0.084172346,0.0047253384,-0.0027895689,-0.02790448,-0.0622543,0.04294774,0.04265356,0.035007544,0.08064006,0.074646525,-4.4938666e-08,-0.017652016,-0.036971077,0.019110775,-0.027312241,0.08547317,-0.030176913,-0.017382585,0.0047604456,0.044685923,0.022424914,-0.0049403165,0.11973209,0.10066092,-0.121914245,0.045934156,0.101075806,0.055028964,-0.039208118,0.06866475,0.08505916,-0.07684142,-0.120347425,-0.17564276,0.041382987,0.009412758,-0.019906143,0.058890495,0.052506372,-0.014386569,-0.017078105,0.07371355,-0.01341328,0.042376604,0.038121905,-0.045979038,-0.013413002,-0.058892827,-0.070143074,-0.035307102,-0.014025368,0.05234405,-0.0011632511,-0.035803538,0.06841287,-0.0128744,0.0049015325,0.0342368,0.05084949,-0.027539011,0.052530557,0.011063046,-0.027044622,0.03830223,-0.10741672,-0.07790972,0.020833896,0.079290785,-0.009040911,-0.008873093,0.038078472,0.053488187,0.027104354,0.13536528,0.050350413 +7.1.1.7,"This terminal oxidase enzyme is unable to pump protons but generates a proton motive force by transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water. The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) is 1. The bd-I oxidase from the bacterium Escherichia coli is the predominant respiratory oxygen reductase that functions under microaerophilic conditions in that organism. cf. EC 7.1.1.3, ubiquinol oxidase (H+-transporting).",384,0.99999994,-0.05207236,0.015050182,-0.12775739,0.069179684,0.06480752,-0.005693934,0.037130572,0.031056087,0.0015192106,-0.069548875,-0.004684282,-0.020209722,-0.0028968381,0.05365015,-0.06750243,0.03517174,-0.029677248,-0.008747355,-0.08774146,-0.05817784,0.09260277,0.027227338,0.052887153,-0.07269172,-0.008556231,-0.071257025,0.070325196,-0.02941805,-0.022691794,-0.066789694,0.042626616,-0.096224725,0.05314878,-0.13403054,0.04146129,0.08816094,0.013734342,-0.08212147,0.008494864,-0.0015469353,0.028088512,-0.023961188,0.00065860065,0.068057165,-0.015562225,0.022972658,-0.034725703,0.031757165,0.053207483,-0.030833945,-0.0020922087,-0.023091372,-0.06926136,0.040401336,-0.018236237,0.037769992,-0.040882234,-0.02458047,0.00023212287,-0.056559574,0.0185622,0.03677019,0.095324844,0.009852982,-0.011317104,-0.05940722,0.026402084,-0.04301931,-0.02446107,-0.03601244,-0.038126577,-0.07382327,-0.06720684,-0.05812897,-0.049473546,-0.026161367,0.01085231,-0.05205289,0.019552791,0.0040509296,0.04918287,-0.05809528,-0.002658638,0.07174327,0.0449838,0.0010623197,0.011122069,-0.11249186,0.0006265972,0.04895748,-0.045133814,-0.026789272,-0.0013967468,0.0060102874,-0.086786374,-0.028963776,0.06578299,0.09652027,-0.02561001,-0.033678845,-0.035646103,0.1381901,-0.018935459,-0.05851543,-0.040104717,-0.033596423,0.04352641,0.12761104,0.0736022,0.0071055186,0.058284298,-0.009150299,-0.01110188,0.017616738,0.041419663,0.08621205,0.012205792,-0.017354611,-0.08501097,0.019091995,0.007920937,-0.006345218,0.007933395,-0.017244924,-0.03667041,-0.06840585,-0.09334937,2.5921911e-33,0.057054758,-0.042624068,-0.0062933057,-0.019664966,-0.041429672,-0.036859043,-0.100784995,-0.012924203,-0.0017750625,-0.0012855778,-0.12654825,-0.041468315,0.05083361,0.02580494,-0.0044722073,-0.070905395,-0.040772513,-0.020305699,0.046850402,0.06532812,0.029183304,0.009561969,0.006093979,-0.077532314,0.10113801,-0.0315692,-0.008395004,0.030119956,0.067076445,-0.0037050433,0.05442927,-0.06308445,-0.1251554,0.0027899032,-0.032053478,0.017614113,-0.07252534,0.0064422856,0.00014566793,0.038660653,-0.033023786,0.052724242,-0.0036635406,-0.048492264,0.11138059,-0.0387283,-0.022434188,0.078464895,0.045825846,0.05369843,-0.022317352,-0.014173568,0.12424604,-0.015634274,-0.0037506353,-0.07207963,0.012526042,0.06961905,0.02188987,0.10015994,-0.002211165,0.10856863,-0.06557008,0.06907039,0.012179682,0.06266379,-0.012281381,-0.02494519,-0.0018617285,0.069461465,-0.045403156,-0.006942436,0.030168274,-0.040383596,0.0146930665,-0.02652777,-0.045419957,0.0008129962,0.046820417,-0.027641196,0.008915269,-0.0052789524,0.0026134015,-0.028945351,0.0364245,0.0012805237,-0.036081366,-0.00034831086,-0.030175073,0.020944329,0.10585304,-0.053661376,-0.023688769,-0.08614919,0.030351462,-3.3605727e-33,0.10274415,-0.037828263,-0.010541546,-0.09787462,0.017913686,0.07906609,0.006949321,0.037332635,-0.011943057,-0.0065642744,0.0031865728,0.04967886,0.0086454665,-0.021595834,0.049996156,-0.01749509,-0.06135266,0.0011808783,0.042892337,-0.011813812,0.02121713,0.09955953,0.029911647,-0.014477575,0.020362718,0.024695113,-0.07602239,-0.007872932,0.07370172,-0.0023726213,-0.043857943,0.017370708,-0.028158424,0.0013790454,-0.090737045,0.073727205,-0.100791395,0.048826657,0.10148307,0.034838483,-0.027233418,-0.032609753,0.0054605673,0.024814468,0.007549745,0.11339791,-0.13603903,-0.018408105,0.011582689,-0.03327354,0.040430356,0.021962784,-0.088738956,-0.028894706,0.026810503,0.016495405,0.014071647,0.0075925128,-0.00903657,-0.06311169,-0.0034594303,-0.005036368,0.07176644,0.0016933414,-0.046293326,0.058911614,0.07342714,0.043400947,0.019478194,-0.03075545,0.037783068,0.0021714484,0.0064625936,0.021843662,-0.03291758,-0.04618752,-0.027552012,0.0034056986,0.009820775,0.033619557,0.015806194,0.04079829,0.009670196,-0.09287364,0.03620382,-0.106338754,-0.0016556315,0.017809413,0.032205984,0.055560395,0.038221236,0.002791473,-0.014917484,0.049932495,0.03996352,-4.1274916e-08,0.030427553,-0.055969197,0.08552212,-0.0380877,0.031014396,0.032170705,-0.004700134,0.033611424,0.030735647,-0.024062606,0.0028193814,0.08246541,0.021714915,0.010276887,0.10367518,0.052509468,-0.009111878,-0.0131343715,-0.0026026426,-0.05959633,-0.02386916,-0.022392571,-0.15793201,0.06227754,0.04578568,-0.057885814,0.021994049,-0.029779501,-0.035250623,-0.08353585,0.014595743,0.049813878,-0.031567562,0.026208624,-0.07643716,0.009902887,-0.040384486,-0.008178055,-0.04485901,0.010924821,-0.04974066,-0.027508264,-0.03492689,0.035158217,0.03736742,0.044684295,-0.019331567,0.025174264,-0.037262898,-0.0094620045,0.035145514,-0.09826682,0.051073723,-0.068855084,-0.113285534,0.13196601,-0.03933034,-0.06268078,-0.009473585,-0.040212937,0.05253952,0.044782944,0.12680374,-0.013220036 +7.1.1.8,"The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. The mammalian enzyme contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non-cytoplasmic compartment [cf. EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating)].",384,0.99999994,-0.09150175,0.00574726,-0.12712316,0.0065979105,-0.016107105,-0.013926016,-0.0055412673,0.019132514,-0.02828598,-0.05645539,-0.030188924,-0.053157702,0.02778634,0.017850049,-0.032899037,0.005956211,-0.07441693,-0.032503154,-0.009770375,-0.018409608,-0.019608812,0.007707627,0.011732945,0.005961527,0.021156,-0.0005736998,0.03453972,0.0048229913,-0.06799329,-0.058525845,-0.03809719,-0.059506286,0.07747632,-0.015241954,0.06514729,0.052647434,-0.047582544,-0.06731826,-0.00955608,-0.026704198,0.04621576,0.06694612,0.030136753,0.04998671,0.0027312501,-0.010069683,0.00043052653,-0.021307228,0.103557244,-0.019112539,-0.011011879,-0.008649354,-0.047622535,0.1306997,0.056178935,0.027746657,-0.04948214,-0.031583745,-0.029250197,0.028075539,0.035805404,-0.013214425,0.06111899,-0.008568702,0.05372693,-0.013474337,-0.02852287,-0.05181986,-0.02394894,-0.08355994,-0.058559075,-0.09964578,-0.10244099,0.0053563174,-0.036235042,-0.00537333,-0.011970441,0.009716854,0.015971338,-0.017823614,-0.009018585,-0.056576613,0.030976726,0.12917922,0.027683267,-0.0070870616,-0.005985834,-0.00997404,-0.053011924,0.04587444,0.0018257904,-0.009264787,-0.052181967,-0.00447452,-0.08105901,-0.012072523,0.0270031,0.1143179,0.055763524,-0.03026213,0.053428814,0.10566095,0.06152248,-0.09018026,-0.03395752,0.011594915,0.031266574,0.13871804,0.022484541,-0.03208777,0.010508227,-0.0015372266,0.028402386,-0.02257792,0.013492872,0.09324734,0.068019435,0.01676956,-0.028802332,0.03843551,0.004398436,0.027825017,0.06457214,-0.04394029,-0.013548584,-0.04790067,-0.13467275,1.440123e-33,-0.010969226,-0.009798496,-0.03988814,0.017162733,-0.056196563,0.032092433,-0.07881751,-0.007137368,-0.014083161,0.0017781918,-0.06791398,-0.028031336,0.02808529,-0.04101514,-0.03749808,0.005583721,-0.031416383,-0.050935827,0.069230504,-0.0069326665,0.07383389,0.00911232,-0.035480767,-0.11100043,0.055711746,0.057200003,-0.029389802,0.026095623,0.02763244,0.007683317,0.028387537,-0.11553154,-0.18074064,0.008521323,0.0172644,-0.0044479663,-0.03630166,-0.016353127,-0.015300564,0.07317109,-0.08528817,-0.034496363,-0.008673516,-0.010367761,0.08376685,-0.017474756,-0.069111854,0.04471362,0.014081397,0.037023846,0.035662062,-0.078694396,0.11986901,-0.05068687,-0.069818705,0.021496417,0.06288453,0.042888913,-0.01045396,0.093807,0.053969793,0.11308692,-0.054777186,0.11883983,0.06760615,0.043439865,-0.06769025,0.0067980876,-0.05179812,0.08878024,-0.057757918,-0.011629951,0.12107584,-0.03148144,0.06836383,0.0028375483,-0.08827008,-0.02155271,0.009157925,0.013825774,-0.039633762,-0.10371617,0.015889231,0.0026990422,-0.02057584,0.0025943122,0.03499346,-0.06065567,-0.034424707,0.018868195,0.094738945,-0.020453606,-0.048878636,-0.026930017,-0.007823708,-3.3973223e-33,0.097695604,-0.0538561,0.085406385,-0.14902587,-0.043561246,0.08782894,0.06810999,-0.020830236,0.014411534,0.038120694,0.08794907,0.018917616,-0.031403545,-0.010955829,0.044922803,-0.00525265,-0.038112476,0.040421538,0.010955314,-0.040395666,-0.017111665,0.0009181539,-0.009117302,0.02368797,-0.030382214,0.008519438,-0.014481876,0.01824675,0.10165247,-0.0007554238,-0.07654748,0.0069843326,-0.008835322,-0.06615159,-0.010849242,0.044706065,-0.05823996,-0.04630358,0.077128135,0.01622611,-0.022082945,0.030010777,-0.057733368,0.03210919,0.06208411,0.10490622,-0.11640807,0.04316345,-0.0067831464,0.007175204,0.043618925,0.003091291,-0.0070857345,-0.019670594,0.050175596,0.037680637,0.034672596,-0.022259708,0.023358634,-0.0025233787,-0.03137821,-0.0674531,0.032425966,0.046795573,-0.03856553,0.03266101,0.00073029456,0.021719864,-0.011195827,0.03662299,0.08735637,0.012026803,0.010298914,0.028238462,-0.05398224,-0.010196325,0.049957693,0.033458877,0.029759014,-0.035068363,0.060916685,0.0026505538,-0.014371969,-0.034671005,0.06406473,-0.12530923,-0.03141099,0.071477376,0.013030514,-0.04678671,-0.010560545,0.065114416,-0.06469345,0.020424021,-0.004769277,-4.3061366e-08,0.032295115,-0.039116476,0.027446168,-0.05268581,0.079457715,0.03872083,-0.028022295,-0.036113318,0.028664552,0.017789654,-0.002375475,0.08360666,4.4771936e-05,-0.05353749,0.027011896,0.07507547,-0.018647773,-0.06445547,0.03931085,0.018888485,-0.007088135,-0.040285133,-0.12626988,0.04730281,0.025649808,-0.093427904,0.015523945,0.0020241116,-0.00082579243,-0.021810528,0.006732973,0.039044864,0.009181435,0.03494089,-0.07477349,-0.043129385,-0.030724017,-0.06800408,-0.03756994,-0.017493645,-0.001382725,-0.0807678,-0.04146028,0.0026801864,0.043128226,-0.0031368777,0.015970923,0.0532239,-0.027956413,-0.025816437,-0.019261211,-0.005967732,0.018182099,-0.04609123,-0.07505979,0.111077145,-0.015442673,-0.058138035,-0.0025008125,-0.048003253,0.053265564,0.0410974,0.11523276,-0.039196618 +7.2.1.3,"A diheme cytochrome that transfers electrons across a single membrane, such as the outer membrane of the enterocyte, or the tonoplast membrane of the plant cell vacuole. Acts on hexacyanoferrate(III) and other ferric chelates.",384,1.0,-0.057501033,0.0035481078,-0.07279837,0.009726491,-0.020743476,0.016288852,0.075225584,0.07541249,0.032750163,0.021640649,0.03099417,-0.10542839,-0.077132635,0.007904233,-0.025136797,0.0036848488,-0.01178304,0.04821947,-0.06199499,0.022058861,-0.0022348969,-0.02672603,-0.0117278015,-0.04136778,0.007512814,0.03424901,-0.10626716,0.04020765,-0.030434743,-0.08373547,-0.019664204,0.10274902,0.045161404,0.05709033,-0.038932268,0.08538227,-0.002481996,-0.059469618,0.0030908377,0.015558569,0.029819626,0.041761845,-0.07049755,0.028261185,-0.06369819,-0.02327499,0.032709245,0.024618708,0.007803272,-0.079517975,0.028587235,-0.0051618232,-0.05231121,0.10096251,-0.07401364,0.05693631,0.06344755,-0.0013192924,-0.0010228901,-0.019617429,0.028503906,0.05103608,-0.015111178,0.0537123,0.04948824,-0.09483398,-0.032035235,0.020284675,0.060933877,-0.06280948,0.010120654,-0.05726192,-0.029560829,-0.054829348,-0.0009728371,0.05478699,-0.027636627,0.0029202776,0.054911625,-0.076569565,0.011100148,0.029146412,-0.04838217,0.03091453,0.038605742,0.037134673,-0.030994512,-0.01834418,-0.047996733,-0.010927136,-0.035144046,-0.01028592,0.006871386,-0.004871403,-0.14488356,-0.015010011,0.082642816,-0.0040466487,0.05654702,0.03089048,0.087302685,0.0648117,0.017830193,-0.018901696,-0.024924994,-0.041759197,-0.012425658,0.02125876,-0.03446522,-0.060474362,-0.043990996,-0.056345224,-0.008674423,0.022348728,0.0135949245,0.053291544,0.055512846,-0.023802638,0.03309104,0.037845965,-0.051962096,-0.03546912,-0.07765836,0.0021704491,-0.0053642597,-0.00076614396,-0.04297742,1.3450968e-33,0.040641177,0.002697832,-0.008134931,0.012342131,-0.057309896,0.019908983,-0.0419162,-0.03839688,-0.02968299,0.011269072,-0.12170178,0.043293107,0.01167268,0.04928671,-0.008571562,-0.016389744,-0.13588452,0.0017497985,0.10182633,-0.0012666871,0.025411796,0.037668664,-0.09308244,-0.07301147,0.06237604,0.01474265,-0.094061255,-0.015590566,0.019807514,-0.0011800656,0.052385833,0.00034166712,-0.0372706,0.030143753,-0.007600049,-0.021327013,-0.059973598,-0.056516398,-0.013866902,-0.015792975,-0.07907274,0.014243356,0.014755035,-0.020527136,0.033006195,-0.014836672,-0.10880304,0.045064963,0.06920677,0.0006020924,0.032266445,-0.11302211,0.0700862,-0.07027257,-0.028128646,0.066307686,0.02292212,0.031905666,0.011139697,0.085376106,0.019792082,0.09063737,-0.11540905,0.093556434,0.12642664,0.009864011,-0.07573294,0.0072028395,-0.006862548,0.068848416,-0.14595585,-0.0063649216,0.0680119,-0.0038939563,0.054934535,0.012696833,-0.045204766,-0.043383196,0.0021729541,0.04104914,0.036154855,-0.07796753,0.016690599,-0.08915742,-0.0384787,0.008778411,-0.006781103,-0.062758714,-0.052507266,0.012236343,0.05222687,-0.0058248574,-0.013816437,-0.06717074,0.049367182,-3.9564385e-33,0.015076813,-0.0068952357,0.027494643,0.022497574,0.034584966,0.09072589,-0.053887423,-0.0033953164,0.025689458,0.06669309,0.012321276,0.054529615,0.09789186,-0.027405476,-0.057567343,-0.04547372,-0.0004886162,0.0021304395,-0.016572922,0.061471224,-0.071431436,-0.03315026,-0.017677577,-0.008089221,-0.0081557715,-0.050037462,0.003591769,-0.0688908,0.030203542,0.018157734,-0.027720427,0.022851933,-0.007470476,-0.022934735,0.020589178,-0.049008556,0.031972524,-0.01448158,0.020208761,0.018234253,-0.11081964,-0.003529714,0.09574617,0.024641132,0.022264285,0.065265544,-0.13271789,0.046495162,-0.042215843,0.088483535,-0.027960546,0.04346145,-0.1006705,0.059355997,0.06590727,0.07279135,0.06509949,-0.035112575,0.027509531,-0.001164199,-0.026826572,-0.0901118,-0.0074996613,-0.031197194,0.009968756,0.059299726,-0.025988517,0.023778312,0.030202882,0.02807312,0.11753116,0.012684717,0.00806215,-0.0807209,-0.076344065,-0.054341078,-0.0050672875,-0.060632795,-0.042805113,0.060404234,0.046151236,0.020548137,0.022141665,-0.05464856,0.098528735,-0.10589578,-0.048303183,0.08599267,0.008420628,-0.013581297,0.051469643,-0.03409174,0.004783615,-0.014646094,0.041219372,-3.611383e-08,0.029683731,-0.014087524,0.030180043,-0.043221846,0.024631308,-0.030704685,0.018843422,-0.041641746,0.057484403,0.031277336,0.033614982,0.12648045,-0.0075114137,-0.03381354,0.11660039,0.08165838,0.051855274,-0.038714882,0.014460974,0.03192121,-0.03683206,-0.039447878,-0.07761236,0.036676668,0.09634628,-0.05790829,0.018953077,-0.013396131,0.030153038,0.017621625,0.07518887,0.044716634,0.0047475747,-0.026676267,-0.049555752,0.050133187,-0.0022564845,-0.06253729,-0.049511354,-0.025667595,0.06274595,-0.012359182,-0.06186534,0.014910812,0.01730601,0.039685298,0.03303475,0.045620874,0.0050166277,0.03407637,-0.04413839,-0.007541254,0.0428595,-0.110155985,-0.07933562,0.06164373,0.0144088,-0.021804186,-0.020103514,-0.05721187,0.01443094,0.037880994,0.15156694,-0.02355748 +7.2.2.5,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of Mn2+, Zn2+ and iron chelates.",384,0.99999994,-0.071240336,-0.08009747,-0.034492638,0.015949013,-0.036963142,-0.0014087826,0.06587987,0.06433967,0.030166568,-0.070628956,0.030754179,-0.0484733,0.030449968,0.08228842,-0.013383634,-0.06365151,-0.059785996,0.020594707,0.019179981,-0.0017410045,0.0072157104,0.091811866,-0.0122972205,-0.014852125,-0.07762191,0.027418323,0.031737722,-0.02405424,-0.040220227,-0.004546636,-0.07636614,0.0068092025,0.027920147,-0.004050926,0.05079178,0.080592945,-0.008945963,0.0054585882,0.0647179,-0.006075911,0.1040719,0.0027824154,0.12231223,0.033791646,-0.12497009,-0.027796626,0.11575321,-0.011867461,-0.011846692,0.02788567,-0.014015628,-0.013269425,-0.06136329,0.077166125,0.015519468,0.055635422,-0.016561935,-0.000799483,-0.030706871,-0.053232893,0.014352136,-0.021364853,0.056869425,0.072902694,0.016837941,-0.038262703,-0.035101973,0.025168963,-0.019236933,-0.021467542,-0.050493453,-0.03909126,-0.058427054,0.03770768,0.024962023,-0.0232845,0.034819353,-0.013798887,-0.011415186,-0.02674222,-0.03865792,-0.03247079,0.0180002,0.038471237,0.023414077,0.0076902388,0.010008383,0.027040526,-0.017969294,0.028405871,-0.032236714,-0.013502764,0.050895847,-0.052039854,-0.11392839,-0.030636372,-0.0034536025,0.064236164,0.038474116,0.0032327434,0.06700764,0.08368505,0.016829474,-0.01857712,0.03808624,-0.012760791,0.008584571,0.05722342,-0.030014819,0.03924159,0.029461633,0.025478913,0.020517068,-0.06430607,0.0061080535,0.06848152,0.020204676,0.0066032102,-0.06603992,0.027707161,-0.044858616,-0.081385165,-0.007366701,-0.0506353,-0.012653302,0.024255041,-0.084295295,-7.3895675e-34,-0.10419687,-0.0414476,0.00711604,-0.0059075067,0.006161292,-0.043998383,-0.016791875,-0.07085602,0.0029345092,-0.06089938,-0.0368503,-0.01935123,0.03039806,0.10155399,-0.06701765,-0.0310187,-0.09931241,0.027291343,0.10207561,0.0066344645,0.069381155,0.040151842,0.05293418,-0.0772665,0.0771258,0.028711375,-0.010844791,0.00027255915,0.050415948,-0.027528115,0.028452085,-0.09584548,-0.11063865,-0.034342736,0.106885605,-0.05427298,-0.037935615,-0.0034047302,0.020176986,-0.051671736,-0.060701743,-0.022262266,-0.10029933,0.0747406,0.056292027,-0.038191438,-0.024828974,0.054625012,-0.0369244,0.019515097,0.047456738,-0.13396236,0.06414536,-0.04784551,-0.03200527,-0.021014428,-0.013378255,0.038840186,-0.037339393,0.06514898,0.06556773,0.11040849,-0.0039061916,0.069920175,0.06896328,0.038603395,-0.06593032,-0.10050862,0.06195905,0.10592921,-0.012308591,-0.0013087546,0.07893532,0.04194807,0.040326133,0.014682491,-0.12333331,-0.07537135,0.047838226,0.039401673,-0.038168646,-0.08666564,0.019000687,-0.013080947,-0.12198042,-0.039561156,-0.023957217,-0.03797051,0.032916646,-0.04148776,0.13703835,0.027645338,-0.08372262,0.053002294,0.020499779,-1.1133039e-33,0.07124264,0.010738561,0.110248245,-0.06694938,-0.099599786,-0.018815557,-0.008718066,-0.059106413,0.0028032237,-0.015846945,0.03333929,0.045336418,0.014081236,-0.021213938,0.036963005,-0.07219996,-0.030685116,0.0218717,0.010802898,-0.026434604,0.028561046,-0.014957936,-0.0060143596,0.02598956,-0.07093488,0.00069044944,-0.01010454,0.0593631,0.031778023,0.03281331,-0.03202929,0.025800047,0.032528408,-0.103048734,-0.040529903,0.018193211,0.0113233,0.04654383,-0.009686718,-0.041113127,0.017884703,0.002322345,-0.0052431705,0.091249704,-0.023143476,0.036479067,-0.034839798,0.03909659,0.016078256,-0.0033268225,-0.007073279,-0.02153514,-0.050964206,-0.029817982,0.0860981,0.08892545,-0.026216632,-0.0015958087,0.080342695,-0.08015687,-0.06918865,-0.08399735,0.08661616,-0.04666589,0.008258936,-0.0032282851,0.03423586,-0.06152714,-0.03194566,0.084944,0.090998426,0.02670214,0.019954162,-0.02569575,0.008032107,0.027132286,-0.0068076053,-0.029667366,-0.07226041,0.03685617,-0.041105866,0.023392616,-0.04257415,-0.009964403,0.09294292,-0.024951888,0.010534791,0.007790877,-0.020016287,0.0023213495,0.029789293,-0.03094552,0.0072330893,0.003027197,-0.09974392,-3.348873e-08,-0.03296311,-0.06291602,0.0051675406,-0.053844206,-0.027099924,0.03364829,-0.06124678,-0.0005630643,0.105117336,0.0657155,0.050752226,0.11483952,0.011842928,0.013791356,0.07648389,0.066941306,-0.037371065,0.0013607006,-0.015771884,-0.053235456,-0.051143814,-0.024824817,-0.03364118,0.07583346,0.06872075,-0.04392666,-0.018824436,0.060451984,0.0024384952,-0.08438386,0.04131893,0.023305772,0.0059618377,0.0029382983,-0.0385032,0.026024787,-0.034164354,-0.011202798,-0.071647525,0.06974292,0.0053006657,-0.034873847,-0.082370974,0.017566226,0.031520687,0.036055453,-0.072833866,0.09522871,-0.063626155,-0.021285223,0.02988887,-0.03629435,0.011785817,-0.03651996,-0.06952099,0.049106143,-0.047887642,-0.01108366,-0.027746147,0.088946156,-0.008307247,0.023847703,0.090313055,-0.072922304 +7.2.2.6,A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A bacterial enzyme that is involved in K+ import. The probable stoichiometry is one ion per ATP hydrolysed.,384,1.0,-0.028719306,-0.0322463,-0.0002149976,-0.022435265,-0.041543074,0.017325127,0.03788858,0.01647665,0.038583394,0.033396963,0.02083996,-0.012846904,-0.039505016,0.11391458,-0.057486735,-0.0971376,-0.07147553,0.029725999,0.09083537,-0.014689027,0.052254625,-0.0071944427,-0.0025381166,0.007696648,-0.03141003,0.06687271,0.03857163,-0.041826554,-0.013470422,0.0006924691,-0.15355752,0.0027600764,0.050006364,-0.022006005,0.06321462,0.123056576,-0.0967741,0.009700181,0.044415664,-0.03789962,0.14043677,-0.020809777,0.035901576,0.054284174,-0.04200037,-0.0073259403,0.05094114,0.028822789,-0.031836722,-0.085493654,-0.02509813,-0.04069664,-0.11795015,0.02275606,-0.013075283,0.019483158,-0.04742105,-0.01629371,-0.0055687744,-0.024587093,-0.02075602,0.014062766,0.019298386,0.059391167,0.07529131,-0.042504884,0.04081572,0.053656504,0.028495664,-0.033429846,-0.028603349,-0.024724685,-0.026354289,0.0023332697,0.019312618,-0.03809692,-0.039981067,0.01765003,-0.0074356683,-0.0741024,0.049980406,-0.02326479,-0.07220051,-0.030232444,0.036710236,-0.025407858,-0.034036797,-0.01409757,0.030236084,-0.031529192,-0.03391985,-0.040770955,-0.0031745469,-0.049209718,-0.087363236,0.027641129,0.0034642678,0.044494513,0.052472305,-0.0014688842,0.048991002,0.11469424,0.04671132,0.017630212,-0.0134494705,-0.018399524,-0.0315919,-0.031844743,0.0056313574,0.07486617,-0.06896135,0.020219333,0.035162818,-0.03276516,0.04800082,0.063023575,-0.0034987007,-0.0024487432,-0.020465586,0.03755664,-0.031796873,-0.11247282,0.004966461,0.015931427,-0.043874945,0.046789095,-0.024496702,8.162066e-34,-0.010117979,-0.02370193,0.06779906,-0.035563204,-0.022918466,-0.043553974,-0.03986636,-0.070947886,-0.042735837,-0.1263801,-0.05815593,-0.036279187,0.020463891,0.042292036,-0.02674854,0.004544027,-0.076509275,0.085507296,0.132504,-0.0059732436,0.04979624,0.013798008,-0.015522986,0.067849874,0.058996,0.019988047,-0.015281068,-0.0039658654,0.015217442,0.0063729766,0.04313602,-0.055679712,-0.09444464,-0.013724183,-0.027900662,-0.07382907,-0.11202367,-0.02900062,0.056809388,-0.04431085,-0.14415045,-0.047025654,-0.0134866275,0.017052354,0.0072475686,-0.02651249,-0.038112532,0.062341306,-0.004659613,0.06486893,0.026945995,-0.0834522,0.08128423,-0.04562838,-0.06771022,0.05441031,0.06509077,0.0026723896,-0.025031965,0.030184012,0.11102437,0.09887152,-0.03823811,0.01997171,0.0009375173,0.06536846,-0.11195732,-0.0827818,0.07247585,0.09373757,-0.09471877,0.027115226,0.0069043348,0.0071708965,0.044277098,0.0162952,-0.017826146,-0.018661711,-0.032159008,0.051539432,-0.06549906,-0.07853717,0.021087142,0.019953031,-0.059261642,-0.042580184,-0.015489018,-0.046736978,0.024850627,-0.0082387095,0.081549965,0.008738916,-0.029770456,0.07952714,0.048326984,-2.453042e-33,0.11244918,-0.04051309,0.08399434,-0.059731144,-0.05031569,0.038206022,0.023237715,0.0099446075,0.01927395,-0.0032935475,-0.012457141,0.035067104,0.0075704446,-0.0140400985,-0.007814213,-0.012703502,-0.017913181,0.10585296,0.038308565,0.03622149,0.049113404,0.03267637,0.013384938,0.009960252,0.018512739,0.021249836,-0.02116278,0.07387916,-0.009751808,0.008931137,0.0013303184,0.011041829,-0.033457216,-0.032637678,-0.0882681,0.026506951,0.0294579,0.03796279,-0.0096257655,0.039239004,0.09344626,0.079203136,0.057629444,0.0131624425,0.025384301,0.02460305,-0.004098528,0.010084751,0.029576592,-0.07145267,0.0045395945,0.09404669,-0.08214167,0.008389206,0.043037865,0.07030256,0.0064736963,0.05747096,-0.021343565,-0.080689214,-0.09063766,-0.1658762,0.04904936,0.02718308,-0.016641555,-0.0434161,0.009404082,-0.049245737,-0.010939049,0.03243278,0.0263163,0.10614921,-0.01912156,-0.022736154,0.009580853,-0.025863795,-0.029253107,-0.022004534,-0.011240832,-0.017746095,-0.03433922,0.026440326,-0.034861874,-0.00555554,0.01026571,-0.07371552,0.011859683,0.026388971,0.03234342,-0.0065386845,0.010284955,-0.026867224,-0.03155399,0.0012225504,-0.0075637084,-2.8373858e-08,0.01834886,-0.026989358,0.05236089,-0.0045352606,0.09864403,0.03699069,-0.027632983,-0.021156503,0.08656094,-0.026276303,0.012723637,0.032264758,0.05699209,-0.020935003,0.048585065,0.06057771,-0.0845437,0.017902747,-0.05310041,-0.05475763,0.011455183,-0.031446084,-0.096914046,0.14204226,0.06505272,-0.002892137,0.02038063,0.011293508,-0.069889486,-0.09085084,0.02843193,0.005669114,0.01652725,-0.010019947,-0.027919639,0.05904168,-0.029526185,0.013185084,-0.05743904,0.044431448,-0.047143657,-0.04728211,-0.054837294,0.041018784,0.061451443,0.095214255,-0.01883476,0.028395267,-0.052272167,-0.019526498,0.057250638,0.01212173,-0.061656736,-0.09793411,-0.07643521,0.032368287,-0.020540856,-0.060254123,-0.025528409,-0.041342802,0.09267993,-0.0040483926,0.13737565,-0.03887873 +7.2.2.7,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains. A bacterial enzyme that interacts with a periplasmic iron-binding protein to imports Fe3+ ions into the cytoplasm.",384,1.0,-0.055034425,-0.07884737,-0.050840862,0.022710603,-0.06302899,0.01753942,0.05120885,0.04077157,0.05447452,-0.081830256,0.006684254,-0.054736175,-0.00013786597,0.081257574,-0.021212913,-0.07627653,-0.06987509,0.0396695,0.036338966,0.012451058,0.0045531336,0.08426669,-0.020793932,-0.0180151,-0.09962571,0.054980557,0.03684336,-0.027295934,-0.05074904,-0.023118274,-0.10732712,-0.013602441,0.03394156,0.01359238,0.025354246,0.092305996,-0.029086875,-0.016809903,0.047531668,0.012542547,0.09508027,-0.0190756,0.08858401,0.040999115,-0.13616191,-0.044631917,0.11106847,0.0050955373,0.012769019,-0.0062435595,-0.028978871,-0.009071461,-0.06914196,0.057552505,-0.0005100268,0.037110716,0.028721604,-0.024439845,-0.025140889,-0.052675746,4.0777737e-05,-0.0050284923,0.055476733,0.08231306,0.01997731,-0.05278088,-0.004838496,0.030190805,-0.03345698,-0.026053477,-0.06813156,-0.03855121,-0.07530662,0.039486863,0.034167137,0.007950297,0.035412714,0.00034736114,0.009167777,-0.021096295,-0.034474537,-0.022475716,-0.010577906,0.047184616,0.01628732,0.0028385771,-0.025796587,-0.004482576,-0.018443009,0.057327982,-0.051234297,-0.015601407,0.01755393,-0.054313272,-0.10317949,-0.011596444,-0.0038184233,0.03088183,0.050585914,-0.01800813,0.039187297,0.1100937,0.036477603,0.011285707,0.02571793,-0.018233754,-0.02897258,0.045597643,-0.03897327,0.026906407,0.0010109217,0.008024121,0.030927688,-0.08222987,0.007891445,0.06692458,0.018397944,0.012812977,-0.018704044,0.034543823,-0.034235597,-0.07824857,-0.0031152952,-0.022406476,-0.00923127,0.016514737,-0.10191273,-1.2229549e-33,-0.083893746,-0.027758254,0.012400069,0.024475738,-0.0043188347,-0.057039518,-0.030964978,-0.07520291,-0.010218908,-0.02171966,-0.028295329,-0.00968412,0.051559396,0.060768306,-0.03707754,-0.036400735,-0.09165446,0.03613015,0.05810039,-0.023341103,0.090683416,0.07506206,0.08354028,-0.09892714,0.07426135,0.027757134,-0.041595295,-0.006427811,0.054842383,-0.024516838,0.035592,-0.07029769,-0.09271375,-0.06557028,0.085702986,-0.05936151,-0.028370416,-0.019644283,0.013084864,-0.028194383,-0.06815991,-0.029335735,-0.093267575,0.043043956,0.067465924,-0.04665839,-0.026966015,0.081224754,-0.05450188,0.063612185,0.055725962,-0.134,0.06672398,-0.05137815,-0.029394625,-0.023227323,-0.01769871,0.041357722,-0.058330894,0.10618617,0.07123867,0.123086624,-0.008722955,0.061149202,0.08110075,0.03165392,-0.065483786,-0.06675814,0.059357047,0.13041377,-0.026736518,0.04878712,0.063875414,0.03676992,0.059748583,0.013761554,-0.13801993,-0.07210416,0.038236357,0.020731013,-0.054095726,-0.08926365,0.043315742,-0.017047836,-0.10336847,-0.024191791,-0.015707191,-0.017262006,0.020636428,-0.064015836,0.14495212,0.03463669,-0.06763457,0.06273139,0.021562442,-9.235442e-34,0.06792404,-0.02234767,0.106260575,-0.051690757,-0.07817136,-0.01571053,-0.014927108,-0.03023777,-0.013949716,0.013968161,0.007372701,0.043925676,0.008118696,-0.055683885,0.04159008,-0.051001124,-0.026046542,0.00017177963,-0.026719473,0.0037445948,-0.021377375,-0.012794905,-0.0010700496,0.039895937,-0.08075557,-0.01791921,-0.0017260324,0.04977979,0.014285766,0.027362391,-0.011887909,0.04499148,0.036788255,-0.09892688,-0.066996045,0.012892243,0.0075600166,0.058838625,0.03300276,-0.014129673,0.049757563,0.04443914,-0.00095573306,0.071134664,-0.00436847,0.057852052,-0.045874417,0.06962637,0.048737966,-0.002935038,-0.024515523,-0.034946434,-0.017665226,-0.019702228,0.062498555,0.06846146,-0.0029548577,-0.0131312115,0.07195668,-0.049984828,-0.074359186,-0.07720745,0.121489495,-0.022679247,0.018306462,-0.019841406,0.030258529,-0.03628165,-0.036013015,0.07518422,0.08730803,0.03730323,0.012767382,-0.031321276,0.048573613,0.016409928,-0.0060672374,-0.024145331,-0.081485435,0.033309143,-0.030095486,0.045506734,-0.04784784,-0.026294472,0.09229426,-0.025773618,0.008517353,0.007827479,-0.01187772,0.0025654796,0.024762068,-0.013711168,0.024788277,0.0033053688,-0.06587376,-3.1123687e-08,-0.023316488,-0.026251731,0.014997233,-0.04627197,-0.0174821,0.057941172,-0.06156903,0.0020093697,0.08991331,0.06523894,0.032052245,0.123276815,0.02192126,0.0014157913,0.07195592,0.07878312,-0.027550204,0.012570869,0.0036604598,-0.05477795,-0.062187586,-0.026310336,-0.0318081,0.062356792,0.076021716,-0.054656677,-0.014741845,0.036005996,-0.001934506,-0.06691769,0.025358792,0.031246752,-0.009111035,0.007929868,-0.044240944,0.0040912367,-0.046739783,-0.025415294,-0.07604581,0.060927786,0.041414406,-0.036594722,-0.08697715,-0.02101844,0.018428223,0.06624798,-0.09263265,0.081966236,-0.051677294,-0.021730065,0.03929822,-0.009823862,0.006351049,-0.027737033,-0.05951471,0.035017464,-0.05399064,-0.03792658,-0.000875736,0.05658434,0.00856876,0.013099294,0.09380266,-0.058575474 +7.2.2.8,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 7.2.2.9, P-type Cu2+ transporter, which mainly transports the divalent copper ion.",384,0.9999999,-0.06737596,-0.054040298,0.023025287,0.008356862,0.024760874,0.01042066,0.073928475,0.04185559,0.030089723,-0.028583003,0.015148482,-0.019611957,-0.05707819,0.08936273,-0.052658964,-0.14325948,-0.013340736,0.030930964,0.07696928,-0.009450907,0.04667858,-0.010769018,0.014926775,-0.00029227522,-0.04626043,0.053223036,0.009773712,-0.066963986,-0.018811867,-0.02918005,-0.13499595,-0.031837545,-0.041950975,0.040545143,0.022654124,0.116255514,-0.085936226,0.062466487,-0.021572351,-0.06063942,0.18785612,-0.034655213,0.074240714,0.05330402,-0.038861576,-0.06371351,0.05678771,-0.016865507,-0.027096782,-0.056387536,0.01119054,-0.035068523,-0.05920209,0.047109082,-0.027144331,0.029399114,-0.009937299,-0.04481529,-0.03660649,-0.061505936,0.00076825905,0.0042733634,0.0036963094,0.042272825,0.07936851,-0.057854112,0.06620907,0.058475647,0.00030221735,-0.035085194,-0.018213771,-0.007968266,-0.06981758,-0.012521719,0.02779498,0.021773992,0.022040267,-0.001478895,0.024607455,-0.03279215,0.031183254,0.009364234,-0.027581353,-0.022743398,0.079854436,0.025825169,0.00063378905,-0.03281298,-0.01771875,-0.031423524,0.0026002242,0.025217075,0.009125798,-0.010802552,-0.07183274,0.0071526705,-0.009661199,0.03738322,0.019875161,0.020859953,0.07961113,0.1632471,0.01384069,0.019856181,-0.025480762,-0.0045218193,-0.039269652,-0.023903541,-0.037864916,0.083722636,-0.023123076,0.01604742,0.034865275,-0.07306668,0.021107882,0.061815985,-0.07478405,0.007546053,-0.018739145,-0.0023412516,-0.04692436,-0.06488389,-0.023779077,0.014692286,-0.023779556,0.024352465,-0.0016190152,-1.8380322e-34,-0.058722977,-0.023450976,0.08831556,-0.032427892,0.015718788,0.021856934,-0.0867086,-0.051471666,-0.041272335,-0.10301699,-0.049987737,-0.024108337,0.015296697,0.023117736,-0.00056188717,-0.044249255,-0.042742856,0.043316163,0.13224757,-0.065700546,0.052399866,0.037322663,-0.0087733455,0.051644806,0.08249742,-0.0029740583,-0.026535396,0.009409433,0.039462525,-0.008975527,0.026349137,-0.047572352,-0.03726991,0.006711328,-0.038366046,-0.05089404,-0.074871235,-0.011453708,0.08624255,-0.042679414,-0.08627796,-0.044038825,-0.00927552,0.03407674,0.008667122,-0.07562362,-0.044075888,0.06962658,-0.061712317,0.032503627,0.019883461,-0.09762012,0.060386583,-0.01604952,-0.03161605,-0.008463922,0.026615523,-0.0053952914,-0.02243091,0.014400142,0.1443683,0.09475208,-0.035225473,-0.022842942,-0.026202528,0.062307056,-0.09890054,-0.038318183,0.051355332,0.086976886,-0.076755814,0.041281838,0.0047583813,0.010473687,0.08865945,0.009487967,-0.058015876,-0.04530884,-0.008251189,0.04120046,-0.08653874,-0.055452846,0.047720637,0.06559745,-0.058302887,-0.08507073,-0.04233128,0.016300594,0.06024567,-0.02024292,0.08109039,0.024738677,-0.02979707,0.086690955,0.03124935,-7.745859e-34,0.05855255,-0.006111979,0.05200438,-0.04438477,-0.056038212,-0.031492364,0.026627101,-0.0041118367,0.05265453,-0.01787468,0.014048527,0.004652443,0.013276046,-0.06666457,0.03583255,-0.038673103,-0.06473018,0.11056729,0.013454007,0.055437677,-0.0027249693,0.05735446,-0.007388677,0.04405308,-0.0005633689,-0.016567226,-0.0031413245,0.0688378,0.033099312,0.012805056,0.0061803274,0.03821467,-0.05156993,0.022341527,-0.13892075,-0.004575507,0.05712474,0.031686656,-0.020606525,0.083669186,0.07885948,0.05882652,0.050175004,0.04742177,0.051192425,0.068726555,-0.001091513,-0.003750747,-0.011067477,-0.04050286,0.028984664,0.0944812,-0.066836715,0.03806733,0.072168134,0.08777966,0.048105687,0.0038534638,-0.021490041,-0.08971124,-0.06836789,-0.11260941,0.0019515039,-0.028465692,-0.020612167,-0.059158903,-0.010106808,0.029599532,-0.030895889,0.013198941,0.044495266,0.11503409,-0.028606828,-0.04634443,0.0014637839,0.002619462,0.025269477,0.014396278,0.025192857,-0.033450447,-0.022298846,0.053129166,0.009298312,-0.077335484,0.01717734,-0.017153291,0.00016088763,0.024162346,0.0042919028,0.014020913,-0.029290676,-0.06348144,0.014094855,0.030492773,-0.0011815324,-3.1491787e-08,0.0054164384,-0.016189048,0.044711858,-0.06398288,0.021152407,0.01169344,0.026549524,-0.013641414,0.07667757,0.04026364,-0.0583009,0.03409708,0.05398206,-0.05713757,0.08447996,0.109691046,-0.020732282,0.017640978,-0.027318845,-0.08637869,-0.019928215,-0.026982684,-0.12858938,0.08282077,-0.0044162967,-0.005245962,0.030928459,0.028849216,-0.123418435,-0.068329304,0.03134461,0.013595554,0.022200447,0.016675519,-0.025196724,0.03488873,0.023594331,-0.005047616,-0.040037002,0.03249392,-0.055630486,-0.07204794,-0.04103428,0.005925968,0.06066216,0.06938201,0.016578794,0.027248511,-0.022385506,0.031995993,0.054384023,-0.007631918,-0.020646935,-0.120437644,-0.049430035,0.014482095,-0.02539707,-0.052637026,-0.04992669,-0.0015770156,0.093798295,-0.031743273,0.12561318,-0.04756106 +7.2.2.9,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme from the termophilic archaeon Archaeoglobus fulgidus is involved in copper extrusion from the cell [1,2].",384,1.0,-0.06026416,-0.012670022,0.009379071,0.0040016375,-0.020898711,-0.023480594,0.040403374,0.03267415,0.07260782,-0.014947784,0.024140803,-0.049435373,-0.032629933,0.07737265,-0.07338856,-0.10215714,-0.050761152,0.042593256,0.078427225,-0.031417735,0.104848,0.040730733,0.0060659605,-0.014567791,-0.057148144,0.03216454,0.0049726907,-0.04793229,-0.037344575,-0.04303329,-0.113063365,-0.0016573993,-0.0038122311,0.036754783,0.059357848,0.12315391,-0.09160091,0.02760366,0.0055206283,-0.069124855,0.14253464,-0.010626146,0.054806676,0.039505433,-0.058793187,-0.020659652,0.083828904,0.009993344,-0.005697607,-0.01399204,-0.0075446735,-0.042103052,-0.051077183,0.014646404,0.02130924,0.05379805,-0.01602271,-0.06136768,-0.029489111,-0.05777432,0.0067746337,0.041804384,-0.046802275,0.060526256,0.04478106,-0.042263854,0.06693515,0.019003568,0.0017483458,-0.024851376,-0.026853533,0.054537997,-0.05298821,-0.04715116,0.0019463386,0.074182615,0.035985067,-0.022061879,0.022189012,-0.04831444,0.04540095,0.0194414,-0.013351536,-0.043061975,0.10077152,0.0153778335,-0.00505968,-0.0028848716,-0.01780443,-0.068834454,0.025454465,-0.028806115,-0.041100003,-0.043670136,-0.06444486,0.018786296,-0.00899114,0.017118583,0.019363051,-0.008853108,0.050620332,0.11042149,0.055807713,-0.0596683,-0.015671767,-0.027890505,-0.06643967,0.037315007,0.019501235,0.0607032,-0.07261247,-0.04823026,0.067253016,-0.018162766,0.0337665,0.057409678,-0.06041873,-0.023919197,-0.0529911,0.027789216,-0.07127582,-0.047756687,-0.0201827,0.04486568,-0.049144488,-0.0010121221,-0.028710565,2.9241928e-33,-0.021055484,-0.018262953,0.055754814,-0.0099166455,0.05433654,-0.013739447,-0.030612381,-0.07725599,-0.051939465,-0.072402194,-0.052808177,-0.017144673,0.0173218,0.021181354,-0.046102818,-0.049536802,-0.08606179,0.06425898,0.10231731,-0.04724117,0.032354914,0.05726343,-0.0038827385,0.019083839,0.021066794,0.005307899,-0.039842602,-0.012100358,0.060877956,0.014242965,0.048502766,-0.075628996,-0.06994386,-0.002634102,0.016634021,-0.039506383,-0.045195475,-0.026858902,0.02932755,-0.034636386,-0.07300693,-0.04311886,-0.038442865,0.023382844,0.003089372,-0.063486226,-0.047750555,0.11303285,-0.019758053,0.055808295,0.08276794,-0.07541851,0.09380532,-0.026760573,-0.07023401,-0.012880152,-0.019609155,-0.005401614,0.0016446782,0.008775002,0.09413211,0.11275452,-0.02442494,0.01904199,-0.021741677,0.057164628,-0.062296722,-0.050829202,0.052225646,0.11951799,-0.079941876,0.010913963,-0.01735096,0.015488065,0.059038598,0.04848511,-0.02326185,-0.051614076,-0.0526002,0.058119897,-0.07074513,-0.056363374,0.013251372,0.02102143,-0.014405039,-0.048835833,0.014359817,0.013667784,0.021877937,0.020288572,0.0910321,-0.0118926,-0.044965737,0.10841805,0.046411976,-3.72025e-33,0.08348476,-0.046167802,0.089855365,-0.108827256,-0.045499545,-0.034260776,0.008940422,0.03154205,0.047868058,-0.02946116,0.015665917,0.015514134,0.017681513,-0.018737732,0.03297364,-0.05677825,0.0020144116,0.07713147,0.019363647,0.05093022,-0.019225188,0.050927926,-0.025078513,0.024906276,-0.0063824602,0.021705052,-0.04568071,0.053540837,-0.013222844,0.002432739,-0.036821757,0.07125625,-0.023770886,-0.02065236,-0.11426956,-0.007060437,0.06723289,0.019269833,0.030851165,0.036635697,0.07937651,0.10789522,0.047684893,0.052757606,0.039801516,0.045811944,-0.024003336,-0.032250334,-0.04055653,0.00062271894,-0.02702151,0.08560221,-0.05057746,0.013000762,0.084977075,0.07786787,0.0032468475,0.007668501,-0.05582245,-0.06685792,-0.08031053,-0.118891075,0.011651185,-0.012526775,0.02660462,0.0019420015,0.025327057,0.048937544,-0.037484355,0.033376172,0.053906098,0.116655014,-0.051109705,0.0101196375,0.021752058,0.0044115875,-0.0007675589,0.0027624941,0.009466033,-0.008665035,-0.059058495,0.050981484,-0.013779467,-0.07348821,0.010548344,-0.10619535,0.017998535,0.07997467,0.007546372,-0.033013154,-0.020860663,-0.105713986,0.019130884,0.023943797,0.024615074,-3.3599406e-08,-0.018880064,0.035642423,0.06226733,-0.055659823,-0.0047871997,0.03880679,0.049908757,0.016788634,0.058323532,-0.048538584,0.02171878,0.054269142,0.06761295,-0.05443733,0.062186923,0.11084359,-0.07391354,-0.02045589,-0.0146538075,-0.12019708,-0.009081387,-0.039607015,-0.07905787,0.124678545,0.010848581,0.0076735644,0.042998277,0.011200264,-0.12013273,-0.06306501,0.0116057135,0.024651663,-0.017073106,-0.01466961,-0.06632474,0.0299291,-0.00885978,0.019576864,-0.06715321,0.050182242,-0.039375797,-0.060186945,-0.01397218,-0.019162951,0.02569189,0.061576717,0.045221314,0.044516835,0.0022625283,-0.018400826,0.028967855,0.052641377,-0.032802016,-0.09713305,-0.083335385,-0.011950494,-0.013902692,-0.026205812,-0.053744722,-0.02408072,0.06251072,-0.017684015,0.16073495,-0.0445979 +7.2.2.10,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme family comprises three types of Ca2+-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolysed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolysed. In muscle cells Ca2+ is transported from the cytosol (side 1) into the sarcoplasmic reticulum (side 2).",384,1.0,-0.013816627,-0.032229558,0.013694218,-0.013567463,-0.050434336,0.031199751,0.05916389,0.037317898,0.08950271,0.0070073297,0.014105734,0.012542504,-0.04371028,0.12507065,-0.051371135,-0.13150495,-0.06880926,0.069868416,0.06757945,-0.03196273,0.102412015,-0.0015489724,-0.012398255,-0.0006132814,0.004738221,0.015604624,0.003191157,-0.0288157,-0.024570983,-0.016480448,-0.13726689,-0.018974127,-0.06476386,-0.018136749,0.023759937,0.14756462,-0.03814665,0.02642698,-0.015990691,-0.039074015,0.12550178,-0.008217325,0.026496256,0.0551841,-0.026225667,0.006542819,0.03633347,-0.026360087,0.02281587,-0.025787015,-0.058600362,-0.02586748,-0.09676998,0.060473464,-0.022885453,0.07822149,-0.05947674,0.02821094,0.013521185,0.0009536342,-0.04525007,0.0004629483,0.04130304,0.047200225,0.06419085,-0.05829607,0.00925295,0.026141478,0.021875527,-0.030743437,-0.04808421,-0.0070141344,-0.04560044,-0.028008813,-0.019833354,-0.03229704,-0.027265498,0.02119726,-0.0023219674,-0.06777689,0.078242205,-0.04835112,-0.031563573,0.0053847088,0.07308283,0.019829938,0.032332294,-0.027248854,0.050848518,-0.0125894435,0.014387094,-0.0064659934,0.024395317,-0.0021631531,-0.052082323,-0.012514101,0.0032020793,0.06726853,0.049769323,-0.051081423,0.11488795,0.07476207,0.094799004,-0.00574767,0.0040994426,0.031959854,-0.040212717,6.141928e-05,-0.028845249,0.06869603,-0.024457844,0.049329035,0.008102768,-0.060646806,0.06376021,0.12230155,-0.052089226,0.0060891923,-0.02966516,0.010215674,-0.07914823,-0.118550956,0.003908928,-0.023030864,-0.01448737,0.0325294,-0.06946383,3.6757932e-33,-0.04227774,-0.00026291754,0.038367573,-0.013357328,-0.026174333,-0.034742314,-0.03383615,-0.03223381,-0.049407706,-0.09460903,-0.02279128,-0.0061473204,-0.026372,0.082942955,0.011671079,-0.02298206,-0.04429969,0.0023263467,0.102035485,-0.019398076,0.029877,0.06442046,0.015603686,0.03856913,0.11745096,-0.0022420273,-0.046382677,0.03433616,0.01792253,-0.0117477225,0.050956592,-0.10090499,-0.09132525,0.029976007,0.017868469,0.004709087,-0.04823115,0.032051153,0.057971932,-0.010321998,-0.061364893,-0.045117423,-0.0030447464,-0.031420626,0.013046488,-0.08451487,-0.05206621,0.033283446,0.009508876,0.048691273,0.019299623,-0.065109186,0.09430793,-0.02413614,-0.054572534,-0.0074077942,-0.0028630698,0.0361486,-0.066212796,0.04797372,0.09701851,0.08101937,-0.013275505,0.024066428,-0.0051003816,0.054792628,-0.09794021,-0.064795084,0.03276894,0.08565327,-0.075877614,0.012058058,0.03518504,-0.0069266236,0.06942047,-0.01573219,-0.048031,0.012418156,-0.058362715,0.037656944,-0.037662365,-0.056330092,0.056523703,0.08199781,-0.055688016,-0.022757987,0.03612024,-0.05650676,0.01973345,0.011197661,0.0902387,0.037257235,0.009639836,0.09983843,0.0027442845,-4.8907574e-33,0.10760132,-0.012303773,0.12109939,-0.10676869,-0.09281881,0.04827877,0.03148751,-0.019800708,0.0012463471,-0.0029231422,-0.021830276,-0.0063765105,-0.011406635,-0.05635444,-0.00903838,-0.05486021,-0.024668053,0.08660325,0.01809899,-0.009464282,0.02804124,0.090779565,0.025681188,0.058884576,-0.001962158,-0.010944141,0.023071941,0.046082795,-0.013208099,-0.02350327,-0.046499625,-0.019784994,-0.03915036,-0.002083221,-0.11336306,-0.030107832,0.0028104817,0.036317416,-0.014239688,0.09185333,0.07149963,0.0505905,0.042125788,0.028317818,0.00032156604,0.018162396,0.029216016,0.020359939,-0.03844503,-0.048142917,0.0023975787,-0.0019283848,-0.08602065,0.0100360755,0.06338368,0.059376482,0.030411597,0.049980722,-0.031808235,-0.061240498,-0.08059985,-0.10916252,0.016197117,-0.05722217,0.031651914,-0.026695805,-0.010392073,-0.061509293,-0.040863723,0.02924114,0.051026214,0.060638264,-0.032791127,0.0152026005,-0.003429235,0.031319942,-0.017947359,-0.042507984,-0.014797974,-0.058662236,-0.019075625,0.039582305,-0.015342055,-0.05610309,0.019467441,-0.033199385,0.006110519,0.014240981,0.00035367886,0.0057749804,0.038358085,-0.050317653,0.016060146,0.014009526,0.0304743,-3.8581973e-08,0.044524394,0.000883388,0.0045661028,-0.060037706,0.0005880272,0.038728666,0.03354267,0.033799224,0.064528726,0.027473561,-0.06283568,0.043295663,0.046680417,0.013109257,0.022074977,0.10137127,-0.095877185,0.038441774,-0.033360604,-0.09585204,-0.0070199245,-0.06143958,-0.12138388,0.13895893,0.032667633,-0.022407763,0.025831003,0.020323709,-0.055433095,-0.050494418,-0.036705937,-0.00030054478,0.015482168,-0.053287275,-0.035870373,-0.002969154,-0.016460067,0.0042884243,-0.09542053,0.05496677,0.004905366,-0.090201914,-0.022626959,0.030649213,0.062443193,0.045438923,-0.0015189586,0.012502564,-0.0011227707,0.020569367,0.051538717,0.0057536075,-0.03214523,-0.16136034,-0.11747744,0.044430792,-0.04275489,-0.059015747,-0.010226,-0.038464308,0.057872314,0.002510712,0.12919357,-0.0634438 +7.2.2.11,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of Ni2+; the identity of the nickel species transported has not been conclusively established. Does not undergo phosphorylation during the transport process.",384,1.0,-0.09108571,-0.060990248,-0.010170965,-0.04680419,-0.05281584,-0.01822523,0.11199694,0.03605843,0.028589666,-0.067989826,0.020010483,-0.064883634,-0.009126363,0.10769324,-0.030256921,-0.065702595,-0.041541666,0.049285084,0.030354835,-0.023632972,-0.01409815,0.05941603,-0.06429967,-0.009485304,-0.08143897,0.058042187,-0.0028405911,-0.0728678,-0.035227835,-0.04341572,-0.08335405,-0.017767126,0.010149654,-0.030565217,0.074061714,0.07787016,-0.0040915404,0.02698379,0.008051281,-0.033189792,0.11312441,-0.020574126,0.110875934,0.05252093,-0.086442016,0.019542392,0.071943335,0.041427564,-0.0024185108,-0.062242314,-0.051499683,-0.05401203,-0.00334264,0.06354161,0.0429845,0.07819125,-0.05092634,-0.04553238,-0.0102314325,-0.041001204,0.022955507,0.015123611,0.08661119,0.064180166,0.07730258,-0.02820817,-0.006009069,-0.008025113,-0.032221682,-0.010190911,-0.029211542,-0.06262853,-0.05856759,0.04395513,0.04139054,-0.032986663,0.021954441,0.018647343,-0.009023307,-0.05420606,-0.01627497,0.01468991,0.040957876,0.03310775,0.010354537,-0.0049632504,0.0097701745,0.009034896,-0.014258307,-0.0058573503,-0.052326426,-0.03762926,0.026869122,-0.025551543,-0.124195956,-0.011795726,-0.05150883,0.039244253,-0.0057396865,0.006860842,0.0904953,0.095504425,0.026055628,-0.015666233,-0.012037384,-0.009436556,-0.011556351,0.03153651,-0.012451642,0.05941649,0.042097017,0.023868088,0.00206649,-0.04381077,-0.015060247,0.028677408,-0.018633114,0.0170202,-0.050411996,0.022749973,-0.05189728,-0.077069774,-0.025638489,-0.024937276,-0.0690066,0.050248507,-0.042921435,8.261495e-34,-0.10520365,-0.0641329,0.0023291265,-0.028511414,0.0047396407,-0.08738495,-0.057296008,-0.07703262,-0.010130555,-0.11662626,-0.029204585,-0.021445597,0.005684456,0.07641676,-0.044143047,-0.0057142028,-0.09508803,0.08285694,0.13894784,-0.0005714847,0.04024093,0.05221765,-0.017069004,-0.009093219,0.12173762,0.027772821,-0.045229062,-0.058318533,0.09941352,-0.022032384,0.07044574,-0.070762396,-0.055514097,-0.0075557367,0.057115156,-0.061265867,0.021519497,0.0127058,0.011709277,-0.025782479,-0.07944033,-0.0050550858,-0.08327481,0.10291224,0.035435416,-0.01585941,-0.017990483,0.078987636,-0.026993698,-0.02594138,0.034641616,-0.13384794,0.06361956,-0.0735555,-0.04898546,0.015643686,0.009918727,0.047924336,0.0059999824,0.009424148,0.05880381,0.13678116,-0.026170053,0.02665081,0.061493836,0.039982703,-0.072364315,-0.12879844,0.06326018,0.11601078,-0.057610556,0.026879719,0.06933597,0.05475006,0.04259965,-0.03896674,-0.08889421,-0.10695047,0.047975183,0.058681093,-0.021290291,-0.07031895,0.04533095,-0.021504292,-0.050628033,-0.07248961,-0.05322723,-0.03596202,0.019622715,-0.04399244,0.14124307,0.04400449,-0.07799518,0.0420684,0.01549506,-1.8918441e-33,0.08731514,-0.029929953,0.075034745,-0.0058435276,-0.043790292,0.01397528,-0.009859324,-0.024485908,0.03616058,-0.0006656971,0.027018405,0.037308652,-0.002397926,0.014506758,0.035392717,-0.09418556,-0.033499304,0.059225798,-0.03339899,-0.030511556,-0.018463025,0.00070369063,-0.032008674,0.009676515,-0.060261413,0.039465826,-0.057973944,0.06970832,0.016140766,5.7731236e-06,-0.014593381,0.055631246,-0.024963493,-0.090315714,-0.038427968,0.051267166,0.028825868,0.02306025,-0.055780057,-0.013035586,0.027443184,0.053650007,0.020010358,0.059394844,-0.012935419,0.05111936,-0.033969656,0.060479734,-0.01405324,-0.03866108,0.02650178,0.026702527,-0.05228734,0.0107821245,0.050055493,0.08814939,-0.007876257,0.027047606,0.06898284,-0.063377745,-0.073048875,-0.11771907,0.07335499,-0.011372682,0.009628297,-0.04389589,0.009474061,-0.01250494,-0.017114528,0.050905667,0.032346174,0.060113788,0.062157866,-0.019422835,0.016167898,0.023320733,0.033095736,-0.04094029,-0.014807366,-0.006010822,-0.06396631,0.052784808,-0.017637601,-0.0029005066,0.10030146,0.018506512,0.02103558,0.038706135,-0.0070269625,-0.0021712224,0.03407934,-0.022337748,-0.03595812,0.021126319,-0.11253608,-3.810212e-08,0.03864331,-0.032987244,0.019679155,-0.052336354,0.017343191,0.06900744,0.009749801,0.018371036,0.10162906,0.04663589,0.037854712,0.11077767,-0.010353955,-0.016629148,0.06720984,0.06456052,-0.0133346915,-0.021949189,-0.033148576,-0.052831512,-0.007432717,0.006627808,-0.05136303,0.04813182,0.05439117,-0.036166772,0.023253195,0.018060802,-0.04235809,-0.09096731,0.009260776,0.034685154,-0.023620324,0.012643587,-0.00823813,0.016766353,-0.039397098,0.04867754,-0.051660012,0.042994685,-0.015100022,-0.039586052,-0.078797095,0.007348961,0.01543736,0.01631515,-0.05578927,0.05952982,-0.06617301,-0.0014829818,0.002317407,-0.035316143,0.008897565,-0.018334202,-0.085556515,0.02253189,-0.029267801,-0.04619746,-0.038085263,0.054949738,0.046381358,0.022182982,0.08895111,0.034597762 +7.2.2.12,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, present in prokaryotes and photosynthetic eukaryotes, exports Zn2+ and the related cations Cd2+ and Pb2+.",384,0.99999994,-0.0649714,0.021822015,-0.014675965,-6.841403e-05,0.011564334,0.01572844,0.047190502,0.047874507,0.039923593,0.0025081802,0.027460815,0.024576738,-0.0490171,0.09383504,-0.02959283,-0.06802073,-0.07017727,0.03971302,0.10226283,-0.052983098,0.07388289,0.05415458,0.019087795,0.009124933,-0.057862584,-0.011399029,0.038155608,-0.03913214,-0.006920646,-0.004023407,-0.1176724,-0.010457361,-0.021206891,0.010101141,0.04134338,0.12665927,-0.027897498,-0.027535783,-0.0021986803,-0.08143504,0.1952878,-0.004982061,-0.004475802,0.05186813,-0.04598024,0.005254554,0.07463579,-0.019914242,-0.037211254,-0.03719554,-0.01752495,-0.06781943,-0.0708116,0.017083256,-0.0024768321,0.04184409,-0.044808887,0.012733736,-0.005642415,-0.033052385,-0.015562387,0.008433955,0.00791457,0.049512353,0.1011976,-0.048158832,0.037727848,0.04649964,-0.02757924,-0.033151872,-0.032878384,0.014332987,-0.054087278,-0.0317588,-0.05164716,-0.022430351,-0.037692692,0.013891237,-0.036611628,-0.04915449,0.054176904,-0.01986616,-0.006101571,0.0103128515,0.060790427,-0.011572952,-0.002304004,-1.8676043e-05,0.01159614,-0.027020669,-0.010881025,-0.011173896,0.00053524197,0.008430078,-0.14621784,0.024585847,0.050993323,0.0388798,0.067407206,0.009544289,0.09417887,0.10738304,0.05057708,-0.035144188,0.008780475,0.036548126,-0.018967971,-0.008999091,-0.004605826,0.07209245,-0.0661379,0.020694884,0.009778129,-0.082569174,0.027287202,0.04957542,-0.055118043,0.029266754,-0.013029316,0.014507908,-0.051321827,-0.060847882,0.0015259528,0.016696522,-0.037535146,0.038961362,-0.06696345,1.46309805e-33,-0.028599512,-0.021263009,0.06299473,-0.002762374,-0.014826042,-0.014412364,-0.029249443,-0.072222084,-0.07088599,-0.10993358,-0.07958682,-0.06378939,0.036878746,0.00871009,-0.020664666,-0.054682758,-0.053971767,0.04692902,0.14015463,0.034817073,0.024079574,0.0073941047,-0.035843726,0.06774664,0.056661658,0.031960074,0.009798621,-0.01932816,0.03677495,-0.019383973,0.039013967,-0.0711493,-0.07850782,0.0027054977,0.034801148,-0.08675183,-0.078670904,-0.0010215339,0.040630065,-0.092276454,-0.11243336,-0.06231229,-0.04042163,-0.022812806,0.032686695,-0.03923121,-0.03438725,0.05072435,-0.010574875,0.04087249,0.037906416,-0.08628378,0.087069176,-0.0076748594,-0.077839494,0.0022175987,0.0225993,-0.0022537597,-0.004337847,0.029494781,0.10532884,0.07922625,-0.016049754,0.005264479,-0.016156092,0.10438148,-0.110850714,-0.10065938,0.0570542,0.070844635,-0.090117,0.0011811334,0.04809331,0.011681501,0.0949792,0.022080544,-0.0066595566,-0.052823905,-0.035458967,0.085725375,-0.052463524,-0.05945894,0.010110228,0.0190241,-0.028877512,-0.068190604,-0.020662088,-0.045204405,-0.007875973,0.012397568,0.09940853,-0.002143458,-0.009327622,0.06567811,0.027226714,-2.9219037e-33,0.110062,-0.003721609,0.062151868,-0.10694446,-0.053000823,-0.019685727,-0.005125725,-0.035967592,-0.004192371,0.009805732,0.007901009,0.0020517453,-0.017150255,-0.02221401,-0.015080277,-0.034783646,-0.019756269,0.10221152,0.057936694,0.028435674,0.043532033,0.07223536,0.03748626,0.050796844,-0.008312971,0.0075407065,0.02087507,0.08365961,0.045851503,0.015638093,-0.032500416,0.009693088,-0.026846068,-0.03470057,-0.11947928,-0.020838762,0.030439213,0.0030033903,-0.017292546,0.06236596,0.060576715,0.038449164,0.0457689,0.058570996,0.035627075,0.03592272,-0.022127211,0.013256027,-0.032802172,-0.022544721,-0.0046609715,0.07866428,-0.07931237,0.028220087,0.092827514,0.055930488,0.018355416,0.055494916,0.010126103,-0.050299846,-0.046013977,-0.1284808,0.03261472,0.045250814,-0.03603288,-0.051038124,-0.0010202599,-0.01361398,-0.025737919,0.062368207,0.035783164,0.1317081,-0.030027924,0.01509312,0.012924822,0.026856035,-0.004726665,-0.015574977,-0.013148441,-0.014566886,-0.026730578,0.01933815,-0.018469939,-0.057053346,-0.010201055,-0.0936074,0.012562326,-0.004135088,-0.020678652,-0.011647969,-0.01303438,-0.03242548,-0.009452505,0.028309306,-0.023414338,-3.182094e-08,-0.040886045,-0.037691925,0.066411264,-0.054118495,0.033888362,-0.0009052549,0.016220918,-0.0008642473,0.06963736,0.013799237,0.012698653,0.043060947,0.07228085,-0.04616857,0.08002768,0.11087822,-0.01663588,0.004856233,-0.034889348,-0.02212964,0.011390829,-0.040599667,-0.1308513,0.11789663,0.057412393,-0.032667648,0.0074033947,0.043156672,-0.055235032,-0.103398636,0.027650455,0.033427056,0.054008756,-0.04849002,-0.039992057,0.031742025,-0.032223925,-0.024513962,-0.04796036,0.03374313,-0.0717461,-0.02397851,-0.019284412,0.017823478,0.03869356,0.05880294,0.052319124,0.021776024,-0.03774982,-0.013148384,0.051042996,0.013653446,-0.053727686,-0.121657066,-0.0916858,0.03010975,-0.012867014,-0.034387957,-0.037364166,-0.016874233,0.056435853,0.004564927,0.13582356,-0.056933485 +7.2.2.13,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.",384,0.99999994,-0.043924566,-0.0022027162,0.012537781,-0.015506897,-0.048177022,0.023783725,0.07430067,-0.002615741,0.07290095,0.023379495,-0.018291572,0.012566865,-0.04988916,0.1161501,-0.030626222,-0.09771239,-0.042809043,0.034560632,0.0788574,-0.058757335,0.08036656,-0.0029776837,-0.0005830468,-0.0075377277,-0.046982754,0.035866804,0.044848546,-0.04261926,-0.031465843,-0.0034877937,-0.14880522,-0.03626263,-0.016828068,0.015499004,-0.0031775318,0.11852509,-0.120616496,0.06811813,-0.010443999,-0.010626777,0.15445964,-0.041267388,0.035100605,0.016515184,-0.036560737,-0.030523568,-0.0031145655,-0.027447691,0.007585358,-0.040377762,-0.0007580922,-0.021154784,-0.06849793,-0.014472588,-0.024222465,0.007364565,-0.06060207,0.0119692525,-0.0061294334,-0.035947897,-0.010990367,0.021242676,0.031870436,0.06515254,0.119612366,-0.073383674,0.055284865,0.04460037,0.021845024,-0.054903448,-0.02923914,-0.018145619,-0.0061344425,-0.026636349,0.008072478,-0.044487808,-0.050632175,0.026862826,-0.013770725,-0.011666741,0.08170823,-0.009196198,-0.04963292,0.002378412,0.093147755,0.015229888,-0.018496664,-0.022916524,0.002475228,-0.018633468,-0.017396169,-0.047217086,-0.012372754,0.024689535,-0.11309868,0.0061055496,0.0061088856,0.021785768,0.04489756,0.017447887,0.06471176,0.10456367,0.050545394,-0.009040148,0.0065736,0.0046394328,-0.015393191,-0.009278516,0.009417746,0.09061995,-0.073848195,0.004414958,0.016945077,-0.04048158,0.05053415,0.09904478,-0.04207506,8.075991e-05,0.01680373,0.04232587,-0.03449148,-0.105172254,-0.03186611,0.028871339,-0.020799397,0.0653918,-0.035203148,7.132565e-34,-0.03953169,-0.032470893,0.057041623,-0.012853814,-0.013485494,-0.00032722068,-0.041042805,-0.06094937,-0.06170979,-0.11288934,-0.010337014,-0.0030027826,0.056461923,0.04539074,-0.026010027,-0.047864202,-0.07621178,0.035163943,0.12564377,-0.01591407,0.0408982,0.030807734,0.0010005772,0.065735064,0.022293188,0.0024113408,-0.048653807,0.009361912,0.03397766,0.010635778,0.04422089,-0.06110827,-0.07444376,0.0052985325,-0.077307634,-0.06350656,-0.10815099,-0.04749706,0.08839119,-0.046229012,-0.1455799,-0.07591787,-0.009337524,-0.0034562936,-0.0016633708,-0.045509975,-0.053538322,0.08135882,-0.015965011,0.043326356,0.052727215,-0.07634844,0.087507196,-0.03570278,-0.04794364,0.027916247,0.0038511325,-0.00582502,-0.015947413,0.032347497,0.130498,0.09709782,-0.03264793,0.005352054,-0.016754646,0.05245378,-0.07184703,-0.082706586,0.07721393,0.07993838,-0.07695,0.023478772,0.017123364,0.005818329,0.053040117,0.01934098,0.026927458,0.013244402,-0.054088075,0.039413527,-0.018507686,-0.061912753,0.06558762,0.058724,-0.024648229,-0.05455094,-0.0043030884,-0.035303306,0.013092468,-0.012205594,0.080764376,0.017281022,-0.0447973,0.075499326,0.03876653,-2.3178238e-33,0.10973392,-0.026152324,0.045910034,-0.09958163,-0.033780757,0.0066755405,0.044403933,-0.025339328,-0.015066705,-0.0005629573,-0.015857778,0.008314569,0.02091809,-0.038329646,-0.017108383,-0.054946724,-0.017545937,0.04547537,0.05340234,0.0069987527,0.016836343,0.07073586,0.026414128,0.04392764,-0.013014697,-0.0077989236,-0.012148867,0.046141572,-0.010684407,0.01820958,-0.033443175,0.021218542,-0.04014963,0.004969587,-0.08089034,0.00010701886,0.045734994,0.013454302,-0.0069455965,0.035279118,0.054784693,0.07449803,0.07519476,-0.02051989,0.039842714,0.095318675,0.027833063,0.025841754,-0.015823765,-0.07228155,0.007705396,0.09015689,-0.07144182,0.026843345,0.026883697,0.070785455,0.016432729,0.012909503,0.011141287,-0.066501565,-0.08385865,-0.11674106,0.05957536,0.00091062795,-0.020177355,-0.0579123,0.0039629424,-0.042226132,-0.026747825,0.053258955,0.060265988,0.118088685,-0.05118918,0.013565894,0.008132405,0.012353499,0.004601717,-0.020588247,-0.007223152,-0.034336224,-0.021734929,0.04332915,-0.031369634,-0.049009845,0.0040998864,-0.06899153,0.0051441053,0.040236346,0.034009043,0.00042591654,0.028247567,-0.047120273,-0.058136452,0.025188541,0.0026418064,-3.330299e-08,0.028300643,-0.026366886,0.037522733,-0.06069269,0.032415174,0.015021345,0.027416177,-0.035416424,0.08489721,-0.02285323,0.00084514334,0.02621046,0.059461042,-0.007801612,0.06919381,0.074560694,-0.05067394,0.056079954,-0.036398217,-0.068462744,-0.0021849682,-0.037042804,-0.14795291,0.10983839,0.07657889,-0.0022716443,0.039073084,0.009643917,-0.067925245,-0.10444732,-0.007421932,0.01039856,0.032236308,-0.01937399,-0.047110405,0.06479252,-0.021566927,0.0088275755,-0.067640565,0.023037102,-0.049566727,-0.07744418,-0.010530995,-0.005909447,0.032524522,0.07278479,0.012579689,0.0034821336,-0.029445913,0.0095129935,0.022019895,0.013962678,-0.0547424,-0.11908361,-0.08249724,-0.00022401765,-0.038523898,-0.08346627,-0.003539336,-0.054504402,0.098628975,0.011095296,0.1442251,-0.03049599 +7.2.2.14,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A bacterial enzyme that imports Mg2+ with, rather than against, the Mg2+ electrochemical gradient. The enzyme is also involved in Ni2+ import.",384,1.0,-0.07922532,-0.055403307,0.021245731,0.0011140098,0.0013923114,-0.020663997,0.062004242,0.01933562,0.010302356,-0.012465512,0.0012293978,0.011008765,-0.015206209,0.103127606,-0.021408465,-0.09448728,-0.042820092,0.029524779,0.103073835,-0.019181164,0.08221597,0.01810692,-0.0019401137,-0.0034243304,-0.052823402,0.05579507,0.054532647,-0.04920929,-0.013730275,0.002349129,-0.11491328,0.008770355,0.015368411,-0.03845271,0.061367746,0.14525019,-0.046198234,0.04153553,0.01572729,-0.060997926,0.13549338,-0.013522394,0.07778766,0.032745965,-0.008683197,-0.0303415,0.07663786,-0.010851982,-0.022182474,-0.0714976,-0.053121176,-0.042182207,-0.07164395,0.017226478,0.013734724,0.02243274,-0.0497324,-0.03516017,-0.021576049,-0.04330581,-0.0073848693,0.023873469,0.011496009,0.028376691,0.089415535,-0.0305265,0.06872452,0.0311993,0.019256938,-0.03387834,-0.030909179,-0.007657393,-0.055364314,-0.0063403407,-0.010201732,-0.037279427,-0.002639937,0.012862931,-0.008262591,-0.05515679,0.030784037,0.00656035,0.004732292,-0.0041590473,0.049304686,-0.0293034,0.0057918765,-0.008305,0.017462017,0.007916129,-0.009267622,-0.006645789,0.0054153698,-0.0010820071,-0.112513535,0.009420633,-0.051416658,0.045903392,0.053005546,0.03332127,0.043814655,0.09876062,0.02029686,0.01971306,-0.021228243,-0.007661958,-0.013880469,-0.023236554,0.046364035,0.088392496,-0.0131752165,0.02557524,0.029491873,-0.013660776,0.026257487,0.066535,-0.029313833,-0.0015858489,-0.01522882,0.03232026,-0.04570483,-0.06739231,-0.019212265,-0.004790321,-0.056009255,0.06746446,-0.045034185,3.8256257e-34,-0.030586347,-0.057058968,0.061907537,-0.01545884,-0.024176981,-0.009228698,-0.052020244,-0.07170227,-0.032182857,-0.111221075,-0.053758033,-0.023403069,-0.0067657805,0.053700574,0.010825466,-0.030655345,-0.06729498,0.07490169,0.18244404,0.010138378,0.0117959725,0.05414813,-0.010102495,0.0461531,0.08236416,0.06058801,0.0033949548,-0.058755636,0.055229336,0.0043632975,0.059770916,-0.0942787,-0.06485813,0.0073281596,-1.8903723e-06,-0.05972865,-0.06916869,-0.0285498,0.034795158,-0.060849886,-0.15880221,-0.040952776,-0.03876309,0.03686208,0.004099588,-0.052968908,-0.02072991,0.05717797,-0.02457458,0.054622516,0.0370811,-0.055670857,0.06928065,-0.03829497,-0.08573892,0.032508574,0.033511963,0.032766465,0.0050607654,0.004353271,0.116293386,0.09687898,-0.010118504,0.0050995983,0.02700142,0.059625793,-0.08571886,-0.11537174,0.07426652,0.11188115,-0.105447985,0.0043624635,0.012938052,0.04236549,0.033178855,0.0013865447,-0.024268594,-0.0329936,0.008436056,0.032398414,-0.06682044,-0.07407474,0.024579195,-0.007488194,-0.060364764,-0.05473047,-0.02802442,-0.059210464,0.017937763,-0.030039733,0.0786946,0.01894849,-0.03636424,0.08787731,0.03731104,-1.4802253e-33,0.09299801,-0.032832723,0.061669383,-0.07495311,-0.0774352,0.009589624,0.01407575,-0.029864747,0.024800057,0.011321264,-0.011934018,-0.0010550054,0.0049496386,-0.030296465,0.004135986,-0.07913815,-0.023305373,0.09547117,0.0042938897,0.016306335,0.049025256,0.08482321,0.025145572,0.017450543,0.0074484195,0.026919723,-0.008426469,0.08925119,0.022994423,0.016914725,-0.0062423144,0.060869955,-0.031630576,-0.061442155,-0.09977956,0.030111287,0.058194406,0.0036264518,-0.03883066,0.045570765,0.06796599,0.09280802,0.083639815,0.05156502,0.008657702,0.03411523,-0.04046349,0.04058329,0.0051916135,-0.06719716,-0.01060432,0.0892805,-0.08845901,-0.00045826653,0.040428754,0.010218565,0.0024017962,0.027778916,-0.01156286,-0.06528888,-0.07741809,-0.15313573,0.040478516,0.01097789,-0.02038004,-0.011897764,0.044063263,-0.055488862,0.03130788,0.07357178,0.039216734,0.10086781,0.006921984,-0.0077357534,0.0114908535,0.028455341,-0.0010342201,-0.03959422,0.008781456,-0.05914758,-0.017223313,0.036294557,-0.005895277,-0.017429989,-0.01525459,-0.09848964,0.008124127,0.047927648,0.038746107,-0.016778095,-0.018151995,-0.052924562,-0.032252576,0.0033556272,-0.06708197,-3.0636183e-08,0.0009003334,-0.04257362,0.07842275,-0.0064314413,0.061340235,0.037521746,-0.05292373,-0.023551334,0.10701151,0.008150532,0.0049697207,0.028488953,0.021537377,-0.05989319,0.056866415,0.07584777,-0.03851864,0.024070447,-0.053950638,-0.06248467,-0.0043782787,-0.020323535,-0.12600838,0.13716048,0.070756964,-0.03966981,0.0053886543,0.018999105,-0.079622515,-0.08539221,0.0047943923,0.01970107,0.028760634,-0.0011093145,-0.057665043,0.030129528,-0.020939125,0.0063488344,-0.059528254,0.0020412544,-0.053704448,-0.05529695,-0.03002793,0.0017405155,0.026788766,0.05590431,0.006374528,0.017190976,-0.04968192,0.020765841,0.059546232,-0.011019357,-0.036392562,-0.07136681,-0.085297085,0.027290909,-0.0033842844,-0.06682604,-0.04358978,-0.037811205,0.08099222,0.0012810143,0.11744506,-0.0378018 +7.2.2.15,"A P-type ATPase that exports Ag+ ions from some bacteria, archaea as well as from some animal tissues. The proteins also transport Cu+ ions (cf. EC 7.2.2.8, P-type Cu+ transporter).",384,1.0,-0.08668622,-0.07420012,0.04492935,0.034447987,0.06290729,0.03627642,0.08132377,0.06410579,0.048670597,0.00304051,0.019440474,-0.054197706,-0.071471795,0.062223125,-0.092273116,-0.10207306,-0.029605132,0.0734944,0.01952457,-0.046791084,0.018216016,0.050706636,0.0140863955,-0.016354665,-0.04264595,0.06463804,-0.016214333,-0.104607284,-0.027329948,-0.020447329,-0.06544264,-0.09082791,0.08021253,-0.007356766,0.03140073,0.09806467,-0.076648824,0.05317943,0.00024250986,-0.08357292,0.18976082,-0.02621497,0.11047993,0.012415759,-0.045626946,-0.03412695,0.06741896,-0.041780066,0.046093743,-0.023135876,-0.021160845,-0.012448974,-0.10857292,0.043986093,-0.028131392,0.028121797,-0.0402355,-0.105835356,-0.038574774,-0.043536782,0.03205243,0.019475238,0.015186159,0.02561555,0.04347697,-0.07115612,0.04223319,0.09940387,-0.028701471,-0.06294979,-0.036649596,-0.002993614,-0.07208632,0.01061962,-0.000121569,0.0077354023,0.0114071015,-0.036020704,0.07437529,-0.01868681,0.025549233,0.03263388,-0.04544169,0.01182451,0.053665593,0.002510925,0.04338717,0.030877909,-0.014555105,-0.05000196,-0.02074951,-0.041469794,0.039809212,-0.028129125,-0.057005867,-0.0034524582,-0.030666824,0.010285428,0.039519273,0.018759131,0.027871568,0.089297935,0.05320632,-0.054867223,-0.060945924,-0.047645543,-0.07095902,0.054824755,0.023626138,0.1133569,-0.024585837,0.018118933,-0.025924867,-0.044017717,0.032000683,0.07359147,-0.030464847,-0.050180152,-0.048995815,-0.017426725,-0.049290296,-0.08523142,0.03447558,0.046963055,0.016617058,0.027949188,-0.01796007,-6.385341e-34,-0.04108232,-0.06719323,0.054397088,-0.010874531,0.04112243,0.049641818,-0.081532225,-0.03847826,-0.0009831829,-0.043591265,-0.10819254,-0.018340535,0.01827865,0.04564437,0.009517033,-0.0057345177,-0.065527335,-0.0035965047,0.14057514,-0.018886413,0.011628384,0.05727889,0.016563226,0.05114031,0.12530309,-0.042447455,-0.016898379,-0.034521256,0.024436021,-0.024497064,0.03213847,-0.079094455,-0.07704644,-0.009496898,0.003742591,-0.010105016,-0.08147162,-0.07349285,0.046362605,-0.0022101463,-0.052964587,-0.0065343785,4.9224866e-05,0.017702326,0.04396818,-0.052223645,-0.08515341,0.07541799,-0.025501847,0.040215753,0.021511778,-0.08813927,0.08394104,-0.031133575,-0.0651987,0.0066494225,-0.017201552,0.042938925,-0.022487938,0.044049405,0.09999931,0.091057934,-0.033581935,0.00540051,-0.017905109,0.045535173,-0.07475146,0.014827361,0.045381587,0.061510425,-0.06965635,-0.007278329,-0.022634743,-0.01563271,0.02788685,-0.0046939114,-0.0949876,-0.019010466,0.0031959729,0.018665105,-0.08315101,-0.06509042,0.030680297,0.063327774,-0.08380932,-0.017720485,-0.07682543,0.023430204,0.098804206,-0.06535904,0.07623311,0.01249047,-0.07731177,0.08061994,-0.029137399,-9.632104e-34,0.042279106,-0.06140551,0.021582479,-0.03548427,-0.042604044,-0.014762935,0.02837233,0.016483067,0.0043620383,-0.0036192692,-0.02006746,0.027729297,0.078086816,-0.07827063,0.036488995,-0.049437355,-0.029794715,0.06786158,0.021126244,0.03295588,-0.012002779,0.038828135,0.045382887,-0.0014054369,0.009072803,-0.0011033497,-0.002038836,0.087515526,-0.0017022233,0.005378543,0.027433,0.033122957,-0.014895326,-0.031810038,-0.1379299,-0.05061526,0.060051505,-0.014306922,-0.03422266,0.04553124,0.086675204,0.061600324,0.07512263,0.07818157,0.006464079,0.077513024,-0.0075078164,0.010826781,0.0016989892,-0.05781786,0.05163241,0.023270773,-0.040451888,-0.029572593,0.03204694,0.03301274,0.04574518,-0.00035742985,-0.037776746,-0.06890335,-0.07474799,-0.10267916,0.07122112,-0.01821756,-0.020936368,0.020413687,0.018252883,0.034848344,-0.09121536,-0.006674214,0.05646025,0.0661861,-0.026228456,-0.01776448,0.0035336774,0.030918721,-0.0029697996,0.013049734,0.06645512,-0.022454623,-0.022672268,0.00072254514,-0.007923831,-0.051500272,0.048376262,-0.03133668,0.020662146,0.049953733,0.002592426,0.055882793,-0.042517226,-0.026579225,0.0063180267,0.04134688,-0.021933146,-3.01759e-08,0.00028845645,-0.00014551358,0.037428185,-0.035338532,-0.029943287,0.04181488,0.027291158,0.028227348,0.08290423,0.014534831,-0.051959597,0.052829493,0.0034443664,-0.018899785,0.10607553,0.10645072,0.014830996,0.0029740273,-0.02756414,-0.08829038,-0.036517266,-0.015697442,-0.0671407,0.060590588,-0.013397376,-0.0390704,0.039097514,0.028471591,-0.054258775,-0.081412286,-0.004772924,0.032658957,0.020259375,-0.02118603,0.009508763,0.050629012,0.015817378,-0.08877585,-0.010682358,0.005727781,-0.046812724,-0.022999521,-0.055341933,-0.030400522,0.034637082,0.06959198,-0.019687906,0.042896148,-0.020606749,0.036916047,0.06591338,-0.0050467458,0.012174262,-0.10656704,-0.06529306,0.0021413704,-0.027614217,-0.10466551,-0.0074915625,0.031490266,0.08196959,-0.04415613,0.12285922,0.009798384 +7.2.2.16,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of Fe3+-complexed hydroxamate siderophores such as coprogen, ferrichrome and the ferric hydroxamate antibiotic, albomycin.",384,0.99999994,-0.074002884,-0.08946071,-0.052681502,-0.014720768,-0.07283922,0.007825588,0.027473181,0.05851508,0.036005307,-0.08922568,0.024511896,-0.07021776,0.007523798,0.08253082,-0.01667978,-0.055540625,-0.060591955,0.020053746,0.039585896,0.0105665475,-0.030299611,0.10200489,-0.009462233,0.018443154,-0.111690015,0.040686782,0.010156125,0.011427602,-0.046652187,-0.030178767,-0.05070923,0.04405675,0.03825221,-0.0028094104,0.010805032,0.0846314,-0.02288953,0.0026799468,0.09734055,0.03587556,0.064393274,-0.024185823,0.06582791,0.045939703,-0.14861411,-0.051320665,0.05621599,0.019186158,0.023707887,-0.0055914596,-0.023432909,-0.025879573,-0.06352915,0.084553555,0.026301429,0.0146952355,0.0029057225,-0.030493047,-0.029815646,-0.038506985,0.0010326327,0.014915181,0.0833408,0.10835089,9.951782e-05,-0.07484701,-0.056060556,0.015576535,-0.006618075,0.017127074,-0.09169823,-0.084592104,-0.05568693,0.05218841,0.03654372,-0.022233814,0.006433686,0.00897336,-0.021073714,-0.049440145,-0.015580951,-0.053088665,-0.015869135,0.0673528,0.04934376,-0.041554693,-0.0021488555,0.0057384367,-0.0033093768,0.04711642,-0.029401451,-0.04482487,0.040875595,-0.05159121,-0.115195714,-0.039827406,-0.028516123,0.029585127,0.011373171,-0.010672343,0.02015252,0.055129163,0.07344013,-0.015669322,0.012816948,-0.030228775,-0.015464207,0.059587177,-0.017368013,0.00024495143,-0.047145568,0.019043857,-0.013874631,-0.08889376,-0.006277757,0.05528118,0.03625949,-0.006640066,-0.030520542,-0.0047210264,-0.05849158,-0.09373598,0.009825502,-0.04294606,0.0019232562,-0.000114072864,-0.09776463,1.5190975e-33,-0.07709864,-0.040239703,0.009305612,-0.016439384,-0.013616013,-0.01821594,-0.016903885,-0.06570345,-0.0060101906,-0.032582026,-0.008102474,0.06299841,0.015901925,0.111464515,-0.0108507415,-0.058301095,-0.12316087,0.05061867,0.089488655,-0.024918133,0.067232095,0.046456378,0.03551369,-0.08226385,0.10132693,0.02401829,-0.037761405,-0.016836405,0.071939416,-0.016183807,0.0023411857,-0.0414795,-0.07620633,-0.052328844,0.059343792,-0.056592144,-0.033375736,-0.03453277,0.030032307,-0.030451385,-0.09992881,-0.046080515,-0.058787882,0.013262609,0.051109143,-0.018974965,-0.02352148,0.08195544,-0.018254181,0.042828895,0.061143443,-0.14904828,0.05336266,-0.08028754,-0.025646256,-0.008098363,-0.03885281,0.050289843,-0.06691434,0.08688279,0.07395494,0.1228368,-0.022604916,0.015509338,0.038211644,0.018720089,-0.031687323,-0.09493862,0.06876477,0.0848474,-0.036949437,0.04842471,0.08376761,0.052960888,0.06135485,0.025807172,-0.11256244,-0.097401306,0.041081205,0.03787675,-0.03947619,-0.06856321,0.062491562,-0.015049892,-0.05511433,-0.035637464,-0.032885794,-0.005800624,-0.0031081652,-0.052451264,0.12594235,0.019730855,-0.06086102,0.090123616,0.014018995,-3.899213e-33,0.076351196,-0.07585562,0.09622637,-0.04256934,-0.05444721,0.007560727,0.030664675,0.012548946,0.0024564993,-0.0017949089,0.016643541,0.0601342,-0.0024706242,-0.0719174,0.027600525,-0.07364297,-0.044978485,-0.0078021567,-0.026299894,-0.03930509,0.016210508,-0.005471044,0.011418337,0.022454975,-0.07246546,0.020996856,-0.020766113,0.044311624,0.02740732,0.027199617,-0.031810552,0.026640479,0.018871015,-0.075414196,-0.04504186,0.04636384,-0.00022905998,0.058401585,0.009019737,-0.023479046,0.033326924,0.03770989,-0.0160872,0.041609738,0.010403906,0.075604655,-0.035736494,0.07352813,0.030361814,-0.002814318,-0.0136442715,-0.010014261,-0.011631963,-0.018820161,0.053015694,0.062321186,-0.021312203,-0.043966472,0.061256923,-0.029786838,-0.05451658,-0.05218572,0.07094183,0.016119936,-0.017017515,0.00088786584,0.013758795,-0.07465442,-0.0112546105,0.084694065,0.101281986,0.006760087,-0.03960321,0.0044273096,0.06108355,0.025692303,-0.016939856,-0.05625162,-0.08079719,0.06656312,-0.011886114,0.030279223,-0.037123017,0.018798493,0.09002112,-0.019568715,-0.010411999,-0.008297486,0.006298574,-0.012784728,0.034902304,0.018163225,-0.006908407,0.040891033,-0.055804197,-3.9552507e-08,-0.00010646321,-0.039238945,0.054700542,-0.069330014,0.031824376,0.029283904,-0.054227524,-0.0068232804,0.084577896,0.048335623,0.029672632,0.12434296,0.008930213,0.040700637,0.06247858,0.07009193,-0.018458089,0.010385985,0.013911779,-0.07810452,-0.022154452,-0.04367778,-0.06921195,0.05684575,0.08970446,-0.03812541,-0.021423602,0.045458663,0.0027265202,-0.04071552,0.06532646,0.026573312,-0.024790186,0.009416293,-0.026975032,0.031488504,-0.07841068,-0.0433772,-0.08992745,0.06486284,0.051629882,-0.023128781,-0.091209516,-0.0075017624,0.06833848,0.06547829,-0.07199717,0.07135808,-0.06355689,-0.014400466,0.047225423,0.0035595673,0.013077002,-0.02984832,-0.06977388,0.03826291,-0.059819426,-0.054483913,-0.012641496,-6.6543944e-05,-0.006012313,0.0060092574,0.1303109,-0.011622062 +7.2.2.17,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of Fe3+-enterobactin complexes.",384,0.99999994,-0.068585835,-0.08521039,-0.057156205,0.0004735064,-0.06854615,0.0012963152,0.059824705,0.050807115,0.03751857,-0.09425993,-0.017321665,-0.079822965,-0.024480155,0.09657322,0.0070830183,-0.07390837,-0.06269557,0.029946143,0.033668984,-0.0073760143,-0.022757728,0.0817552,-0.022967119,0.0072873128,-0.12332126,0.020969233,0.022513766,-0.027047424,-0.03411323,-0.0292298,-0.09955539,0.0064649563,0.076306134,0.013775729,0.022471193,0.09042411,-0.019328265,-0.015591479,0.07812655,-0.003381371,0.10016333,-0.0011580444,0.10340322,0.050575748,-0.13104326,-0.04991088,0.06284771,0.0015051715,0.040927947,-0.02938928,-0.047470957,-0.025902594,-0.0611146,0.086726345,0.026182773,0.03319498,0.022237265,-0.017486783,-0.040124066,-0.06534486,0.004968584,-0.004743491,0.114157066,0.08048133,0.014529611,-0.05927012,-0.043879874,0.017229417,-0.025155423,0.005775757,-0.08093748,-0.044359747,-0.06368167,0.06250089,0.020573841,-0.018453926,0.0077696196,0.04873352,-0.006741982,-0.019808697,-0.010194009,-0.033606067,-0.023542916,0.06429247,0.016076796,-0.024290444,-0.0223139,-0.004110388,0.006369876,0.051521696,-0.023640098,-0.044252276,0.01947569,-0.04322938,-0.11095453,-0.054432735,-0.0034981372,-0.020349186,0.035909582,0.015110856,0.02111628,0.099961564,0.06450326,-0.011541022,0.01088297,-0.030176459,-0.016295077,0.06646305,-0.0016017746,0.022995451,-0.022899583,0.00020363639,0.03682671,-0.054188084,-0.010460711,0.055612754,0.027602127,0.006744496,0.0079950625,0.0399778,-0.03247114,-0.07663263,0.015570583,-0.033204753,-0.032557372,-0.005992764,-0.09555907,-2.604344e-34,-0.07360739,-0.057226047,0.02001956,0.010380038,-0.014500104,-0.03470374,-0.039153717,-0.06900446,0.0030364702,-0.035524447,-0.050620466,-0.0034770328,0.045536622,0.10993728,-0.018269474,-0.034907363,-0.14450854,0.06553794,0.08748897,-0.029978504,0.06850914,0.043006726,0.023315463,-0.06757933,0.1041768,0.04113287,-0.035951108,-0.0013002502,0.057843152,-0.023918396,0.041601315,-0.048311982,-0.10461603,-0.03265747,0.052064955,-0.0379782,-0.008544163,-0.03265397,0.01435807,-0.038178004,-0.08331623,-0.03370206,-0.07269957,0.030534605,0.059962913,-0.04863348,-0.025308426,0.080876924,-0.020975152,0.050825942,0.06272867,-0.15985757,0.05902433,-0.08052977,-0.032339264,-0.016230859,-0.0093589155,0.050134405,-0.025788967,0.06790846,0.07256154,0.09894441,-0.014138466,0.047698453,0.027124723,0.038104016,-0.048452765,-0.077030055,0.06468385,0.11016862,-0.018607682,0.045055322,0.043177087,0.03330552,0.026412288,0.0053779213,-0.11741607,-0.091537565,0.03970639,0.052017376,-0.04001258,-0.08339511,0.043415654,-0.016492546,-0.07180374,-0.0034436989,-0.0359437,-0.029684167,-0.0009822235,-0.058709618,0.14294362,0.06340212,-0.088834934,0.08392051,0.0297319,-1.54005225e-33,0.09176009,-0.05965008,0.093391754,-0.04970241,-0.048376556,-0.022854058,0.0005957017,-0.0031051524,-0.0019170954,-0.008792575,0.00797272,0.05274497,0.019748662,-0.051866148,0.044866253,-0.064512655,-0.04393079,-0.013883933,-0.025522389,-0.038881697,0.022670045,-0.03531796,-0.010188214,0.0071690544,-0.0679294,0.0055658193,-0.052044176,0.064395115,-0.0075693475,0.026571644,-0.040863104,0.019996421,-0.005651563,-0.067739226,-0.048555065,0.03273862,0.012800739,0.028935453,0.0024905782,-0.041612536,0.025060905,0.06363627,0.0026568128,0.06783355,-0.0073417476,0.084878966,-0.008072469,0.049054064,0.04856255,0.018355574,-0.024512425,-0.053729735,-0.008162373,-0.0147611555,0.050402924,0.08669035,-0.002609575,-0.039733347,0.057378624,-0.029349107,-0.049848806,-0.07674127,0.09924247,0.010259874,-0.0004960255,-0.014233856,0.024274291,-0.022931948,-0.0052330177,0.052915193,0.107049026,-0.0010905943,0.008050756,0.0076792077,0.054705672,0.010137791,-0.010316475,-0.00993193,-0.074377656,0.040891547,-0.040512662,0.039551206,-0.058217358,0.027253933,0.07868744,-0.0027456512,-0.01929671,-0.0011539861,-0.01339608,0.017364908,0.00869856,0.02882006,0.00636524,0.021333177,-0.07173972,-3.4168004e-08,-0.012236931,-0.048135605,0.0070322077,-0.046567284,0.03509872,0.051837962,-0.07910145,0.010914585,0.076483265,0.053274736,0.0459242,0.11196167,0.0022995924,0.027521634,0.05827266,0.06273052,-0.041938297,0.004080815,0.0016872701,-0.05455534,-0.031521652,-0.016078744,-0.0312627,0.042889547,0.106040135,-0.046199325,-0.056560438,0.052949347,-0.0042174985,-0.054021433,0.033140197,0.037387796,0.0026240458,0.027002938,-0.044860747,0.04094676,-0.053847037,-0.031759594,-0.08898658,0.06256022,0.04194651,-0.022503424,-0.06561631,-0.031733837,0.03507469,0.05856968,-0.08622921,0.10301328,-0.06848512,-0.02970247,0.04284645,0.0003537544,0.0089108795,0.014457629,-0.055763323,0.037003502,-0.057067797,-0.025911486,0.009720876,0.052845217,0.01579627,0.018555043,0.10016642,-0.017776225 +7.2.2.18,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichia coli interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of Fe3+-citrate in the form of a mononuclear (containing one iron(III) ion and two citrate molecules) or dinuclear (containing 2 iron(III) ions) complexes.",384,0.99999994,-0.07861686,-0.07618681,-0.05373093,0.0038718975,-0.05898904,-0.011834528,0.07534581,0.066866115,0.07071935,-0.113592006,0.004255281,-0.06405569,-0.024306186,0.08718415,-0.010448863,-0.09137807,-0.03956072,0.055584516,0.018998664,-0.063701056,-0.007915568,0.06939319,-0.03726708,-0.0070433654,-0.11812848,0.05038338,-0.0026785284,-0.063220605,-0.024983361,-0.032805257,-0.114721,-0.0066927145,0.056805514,0.023579203,0.012536894,0.08312081,-0.04059288,-0.017257871,0.058222327,0.008464161,0.072129585,-0.011430163,0.08012187,0.037820734,-0.14103465,-0.0833906,0.053050395,0.014013795,0.006656958,-0.010726057,-0.06753975,-0.023481743,-0.043642223,0.053955685,0.030280946,0.028710706,0.0021048654,-0.047844704,-0.021422753,-0.053064104,0.038961362,-0.00016063289,0.07058972,0.06768416,0.050258897,-0.05654312,0.020600738,0.029314758,0.008366757,-0.02575354,-0.07088697,-0.022979394,-0.08052014,0.0434708,0.040245004,-0.020845123,0.0047000633,0.032188088,0.0032506515,0.024825938,-0.018159667,0.012374479,-0.016035771,0.048380505,0.044133417,0.009180793,-0.037006952,-0.005889165,-0.011178621,0.043505307,-0.06415948,-0.02465501,-0.008982407,-0.027237656,-0.10380152,0.018050708,-0.028558884,-0.0039552697,0.015777027,0.020717304,0.055599228,0.12072088,0.0503275,0.0120473085,-0.009955976,-0.014286679,-0.023999507,0.043123588,-0.053810805,0.046559718,-0.026778758,0.00055902096,0.03241811,-0.05504292,0.0015412061,0.08160382,0.012002451,0.018747361,0.063392304,0.035282087,0.0102278385,-0.093641,-0.028737873,-0.037193313,-0.008858346,0.0020288276,-0.07087819,1.9764977e-33,-0.10019009,-0.029749306,0.012991263,0.07280875,0.010519924,-0.061950013,-0.0523015,-0.05891387,-0.048263833,-0.021496117,-0.01112555,0.01761563,0.03699074,0.08955959,-0.015486984,-0.067784,-0.11035871,0.06543598,0.1025872,-0.049854387,0.091261424,0.081043474,0.05122347,-0.04406823,0.07533653,0.03064992,-0.06393213,-0.0017040976,0.037545536,-0.017220994,0.037508134,-0.025263775,-0.08259714,-0.03750836,0.07069195,-0.0530809,-0.04922425,-0.02534502,0.009616197,0.02924664,-0.071361095,-0.006422638,-0.07397119,0.029851768,0.068274274,-0.048788536,-0.03772378,0.068253845,-0.044626947,0.04953286,0.04076046,-0.12943536,0.03383825,-0.08497044,-0.024411649,-0.00867331,-9.3626644e-05,0.0322166,-0.05319369,0.076145895,0.043630823,0.10542563,-0.04632294,0.03350239,0.05120388,0.029898308,-0.09948792,-0.06700721,0.07225531,0.13594757,-0.035878234,0.05937254,0.01155413,0.049297787,0.064827465,-0.0473199,-0.13462205,-0.060414284,0.022584006,0.056816604,-0.03412355,-0.056357034,0.03613966,-0.027547406,-0.10754701,-0.022521984,-0.038559336,-0.03163086,0.027518205,-0.06606587,0.10661648,0.072462745,-0.05307957,0.06252782,0.040036347,-3.7834197e-33,0.06685702,-0.056341507,0.09378451,-0.026689546,-0.09398789,-0.008639386,-0.0049031503,-0.0026283506,0.029937083,0.013412754,0.0145227015,0.05853585,0.026080783,-0.07305291,0.021270178,-0.03377916,-0.003684775,-0.014023263,-0.02876894,-0.014522692,0.0025867482,-0.022522524,-0.00912309,0.025715774,-0.08662066,0.010489272,-0.032965597,0.047501497,0.0115805715,0.022189457,-0.0030530698,-0.013217318,0.014040101,-0.08345593,-0.11344809,0.006248994,-0.00093643036,0.049608365,0.006333771,-0.0006759575,0.046559323,0.06990749,0.037781302,0.049713228,0.0059086895,0.06290692,-0.014912891,0.05231041,0.035927396,-0.031969056,0.015027373,-0.05238293,-0.021121664,-0.010043618,0.06935364,0.07261514,0.017049575,-0.050260812,0.06508284,-0.028447675,-0.051781163,-0.06647266,0.0615138,0.009573055,0.026977636,-0.074241236,0.005424746,-0.014252291,-0.023719633,0.083387345,0.09045048,0.020141888,-0.006805144,-0.056039058,0.0564255,-0.016303323,-0.018693956,-0.00068351097,-0.08513549,0.022551857,-0.04925177,0.029985875,-0.045920946,-0.031601723,0.106780976,-0.001623355,-0.008016185,0.02907808,0.015430127,0.016621668,0.017288065,0.023444338,0.019636074,0.005571584,-0.050848003,-4.1384087e-08,7.573045e-05,-0.048519712,-0.050162926,-0.06196704,-0.006966282,0.050304174,-0.03538962,0.002434554,0.066799596,0.09571003,0.027264815,0.12846693,0.024280991,0.015636334,0.07371723,0.09595342,-0.0022213082,0.020377398,0.012260288,-0.062886715,-0.030762326,-0.024385018,-0.042313386,0.028536499,0.06955825,-0.029270591,0.018145362,0.03540751,-0.0046423343,-0.042298913,-0.0053436765,0.057092197,0.02430774,-0.007542732,-0.034669533,0.030252665,-0.032893356,-0.028447181,-0.0866398,0.022518173,0.051868778,-0.008076903,-0.10720658,-0.019211857,0.033404242,0.046391163,-0.077820376,0.07922612,-0.08281188,-0.02296797,0.047974125,-0.008154674,0.012907665,0.020212634,-0.042923868,0.011103168,-0.051880136,-0.049483813,0.01189751,0.0032424715,0.052579407,-0.01530268,0.08030997,-0.018865468 +7.3.2.3,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichia coli can interact with either of two periplasmic binding proteins and mediates the high affinity uptake of sulfate and thiosulfate. May also be involved in the uptake of selenite, selenate and possibly molybdate. Does not undergo phosphorylation during the transport.",384,0.99999994,-0.07026293,-0.06626882,-0.011639306,-0.0141808195,-0.08900104,-0.0037413808,0.069205336,0.06342318,0.07349513,-0.10783647,0.01657551,-0.027106976,-0.009536499,0.080492355,-0.034322064,-0.025325809,-0.0143935,0.044731885,0.011663728,-0.02603871,0.028068041,0.07678613,-0.059712037,0.031788144,-0.08136405,0.031735852,-0.004769229,-0.037090227,-0.042246897,-0.03589114,-0.12016257,-0.011156069,0.014291562,0.025424708,0.026847707,0.12284679,-0.008895022,-0.021926224,0.04332661,-0.00011485917,0.07785826,0.008408559,0.047645357,0.050727222,-0.14114325,-0.069883086,0.06037975,0.034260646,-0.028663509,-0.019301526,-0.05936183,-0.04925037,-0.064327024,0.05164604,-0.00016702691,0.060150564,-0.023837358,-0.0056680664,-0.009565896,-0.07422241,-0.0328198,0.00808992,0.10338231,0.08520016,0.069356196,-0.0653294,-0.0130967265,0.029063327,-0.016779955,-0.032737933,-0.066563,-0.05197347,-0.027617482,0.07490916,0.03912853,-0.036394577,-0.017632378,0.010322372,0.0049809725,-0.018074611,-0.0036690577,-0.04093564,-0.031627994,0.05249485,0.014419989,-0.0062541347,0.0042416845,0.0019436528,0.013780988,0.020385142,-0.021110343,-0.050199866,0.023644915,-0.046396434,-0.09820486,0.0088458005,0.012255491,0.0076442873,0.018305391,0.0058477493,0.050176475,0.093691215,0.039765712,0.03141506,0.009410285,-0.020661449,-0.010868408,0.020265575,-0.04452535,0.005956263,-0.010544017,0.006595825,0.050057285,-0.043451782,-0.02599997,0.082299575,-0.014660484,0.004443879,-0.012672173,-0.0029396198,-0.045535482,-0.117617436,-0.024249073,-0.036759555,0.0033267997,0.027276458,-0.08680313,2.7798364e-33,-0.034954317,-0.03731846,0.039605364,0.00021364687,-0.010809132,-0.054823212,-0.02521124,-0.025507098,-0.026685376,-0.07831669,-0.02448372,-0.012673587,0.027278936,0.07502642,-0.008159691,-0.028875038,-0.10236506,0.07994282,0.12426661,-0.057588454,0.054521676,0.04168737,0.008203148,-0.057841066,0.048305847,0.015115374,-0.04830054,-0.008677908,0.040827014,-0.00761005,0.046842396,-0.031392336,-0.09517573,-0.024364015,0.071544625,-0.05183368,-0.053777497,-0.0002728269,0.015572206,-0.028419029,-0.0965792,-0.01242385,-0.0742923,0.049403783,0.04853942,-0.0966858,-0.046172976,0.05490131,-0.010525416,0.058479656,0.033956636,-0.14230177,0.07830745,-0.10917982,-0.02305014,-0.017216489,0.003506112,0.017960843,-0.07043936,0.082244985,0.09068533,0.109807774,-0.05855298,0.012004652,0.04970229,0.03898841,-0.09082079,-0.09494317,0.053888302,0.12185399,-0.039546467,0.037560068,0.03125044,0.06408993,0.018194666,-0.008582375,-0.0700316,-0.048433952,0.0024531542,0.06391043,-0.03296448,-0.09293826,0.048271425,-0.019793084,-0.07678753,-0.013173509,0.0006853899,-0.039244104,0.0029772248,-0.006785863,0.108779825,0.03128466,-0.07881467,0.07252486,0.022549609,-4.220196e-33,0.08187767,-0.035335924,0.09209653,-0.03980873,-0.04127876,-0.0009787112,-0.0050605657,0.038391866,0.032988433,-0.021070138,-0.019115476,0.07114023,0.034180745,-0.067026466,0.01877451,-0.050348166,-0.002694795,-0.021111064,-0.04777438,-0.030453904,-0.013206105,0.014182766,0.004777397,0.046322808,-0.07340429,-0.00078237214,-0.022112083,0.050230652,-0.025865767,0.04339675,-0.002424447,0.0049117124,0.009935308,-0.062351104,-0.10565905,0.04761937,-0.011163113,0.057539977,-0.013518534,-0.004242156,0.03625257,0.054091357,0.038886014,0.04618643,-0.0034603726,0.09179605,-0.012607715,0.067184575,0.034055285,-0.023489445,0.025408484,-0.03276609,-0.01893566,0.004756721,0.082080685,0.089348696,-0.029626556,-0.025481932,0.018591577,-0.062189594,-0.04782096,-0.06389313,0.043200374,-0.0141852135,0.01870642,-0.04371043,-0.018111123,-0.0736441,-0.02768197,0.076160006,0.09553129,0.037027847,-0.02628236,-0.014686134,0.044985846,-0.007308722,-0.02760888,-0.021986663,-0.07800109,0.008217936,-0.04601004,0.09218791,-0.01484376,-0.015281389,0.10340948,0.011503567,-0.028742883,0.039062433,0.008008035,0.026626695,0.018851206,-0.002276884,-0.010930775,0.04987469,-0.03897581,-4.1440046e-08,0.004189747,-0.046934746,-0.006309642,-0.055324998,-0.009578139,0.050718613,0.01328958,0.02423023,0.10526769,0.068065315,-0.00042410204,0.14696448,0.010277313,0.010297764,0.07571431,0.053312827,-0.023880584,0.0108728465,-0.03527575,-0.08559993,-0.00324878,-0.06144241,-0.029831367,0.08743987,0.101464234,-0.03148167,0.0094678905,0.029938867,-0.024451064,-0.058403857,0.051071633,0.018302124,0.0028899335,-0.027806588,-0.026786765,0.046299335,-0.046993013,-0.02265039,-0.07363749,0.06689571,0.043031994,-0.023429042,-0.09638966,0.026990078,0.047229193,0.054136157,-0.06904857,0.07186885,-0.06693962,-0.017978255,0.049646143,-0.04511535,-0.007256372,-0.021974172,-0.07227236,-0.025138948,-0.020801043,-0.0419627,-0.0022002342,0.019419584,0.09547777,0.012876436,0.14154933,-0.020580675 +7.3.2.4,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of nitrate, nitrite, and cyanate.",384,0.99999994,-0.10315475,-0.04614994,-0.020652996,-0.04888722,-0.09511326,0.0046958406,0.06486715,0.043765724,0.061433434,-0.079063214,0.03675527,-0.08405128,-0.014582318,0.10693403,-0.036261093,-0.0529472,-0.057341352,0.032758612,0.037619457,-0.033874325,-0.015769454,0.13125154,-0.045952298,0.0059171626,-0.09338869,0.03795313,0.0061549633,-0.054238275,-0.009467985,-0.041905183,-0.079118066,0.010225009,0.026957253,0.0024270986,0.010410335,0.08499651,-0.008782588,-0.006682254,0.07946047,0.017815553,0.12645388,0.002488305,0.09078421,0.068354696,-0.11739348,-0.006555527,0.0586236,0.028718613,-0.0091661075,-0.04128281,-0.02985724,-0.031742778,-0.04260823,0.05935588,0.037877828,0.040967852,-0.016274642,-0.026936734,-0.025720825,-0.048250068,0.047707543,0.021857738,0.08128831,0.075256184,0.043019235,-0.03929353,-0.0320285,0.033542655,-0.009539008,-0.036557395,-0.085138,-0.075718336,-0.042325273,0.059502695,0.024292303,-0.025826655,0.009015937,0.011813042,-0.015409131,-0.029548759,-0.0027978674,0.006743197,-0.0027797208,0.052052222,0.026255017,-0.023281695,0.0069541186,0.020639656,0.011264957,0.0033320962,-0.023545077,-0.039518554,0.026175942,-0.04931804,-0.12231982,-0.020922694,-0.036562063,0.03797393,0.018765626,0.0038814228,0.08018868,0.06303635,0.057205215,-0.009850288,-0.037472002,-0.021655597,-0.0017405712,0.02080525,-0.001731658,0.03163021,-0.04158402,0.006526313,-0.018893069,-0.0835572,-0.022613266,0.05884491,-0.024511818,0.027337072,-0.03403863,0.015414935,-0.073767364,-0.10466297,-0.0038066339,-0.04551265,-0.011322991,0.03871146,-0.08918157,-1.4785653e-33,-0.079169825,-0.062322266,0.032460626,0.0071986574,0.021361623,-0.038888894,-0.018750656,-0.07593305,-0.014402992,-0.097043954,-0.021120228,-0.0016291369,-0.008385895,0.0870764,-0.0064856037,-0.003388674,-0.119335264,0.051929124,0.0995638,-0.0143346405,0.05234496,0.066122144,0.0038450784,-0.058821727,0.11566301,0.0156208435,-0.028971512,-0.04154772,0.072559625,-0.034682184,0.0062630754,-0.03999497,-0.08719793,-0.017777955,0.06469532,-0.060175586,-0.043912206,-0.0069885287,0.025435591,-0.033859942,-0.10283907,-0.014270508,-0.06417498,0.06515409,0.050545774,-0.03473454,-0.030865382,0.07407476,-0.0058316607,-0.00035427968,0.054366827,-0.13176936,0.06355057,-0.07684631,-0.0049281735,-0.0038206843,-0.023339203,0.048570186,-0.047481596,0.03187305,0.08252945,0.10620282,-0.025543496,0.01428733,0.060500972,0.0533521,-0.07874581,-0.106910005,0.07774381,0.10140269,-0.030711098,0.03559559,0.052558746,0.051517442,0.039505813,0.004701303,-0.09524568,-0.080299065,0.017851723,0.02729828,-0.012776768,-0.092602775,0.039875463,-0.015731644,-0.07363597,-0.031719815,0.005356749,-0.01635145,0.022533527,-0.050063558,0.16322613,0.03857447,-0.105530456,0.0572764,0.028475838,-5.665011e-34,0.11744273,-0.029789662,0.065735005,-0.031866428,-0.03802864,-0.025725653,0.0020401184,-0.010484018,0.014383782,-0.009237369,0.0001617708,0.06250468,0.017828314,-0.01586108,0.044479385,-0.06899444,-0.018523103,0.012837791,-0.042189267,-0.042278472,0.020501435,-0.018601483,-0.013973448,0.014621325,-0.0882438,0.018878106,-0.04245866,0.061785426,0.015273577,0.011089408,-0.028929718,0.019077,0.0047203074,-0.08928427,-0.039874308,0.034456827,0.03396361,0.034192838,-0.040010534,-0.026780555,0.019168124,0.07896802,0.033830028,0.06669126,-0.011211413,0.0868054,-0.010451259,0.043083232,0.0023509157,-0.01719981,0.030648712,-0.008646764,-0.03499157,-0.0053969813,0.056766585,0.09596612,-0.0202921,-0.010697176,0.07008975,-0.055802915,-0.06212564,-0.09125712,0.066139996,-0.012906089,-0.002901575,-0.04532066,0.022432491,-0.04298888,-0.02079071,0.067488275,0.09169264,0.037592754,0.004159057,-0.018608619,0.01722494,0.037623435,0.007172917,-0.053614385,-0.062012363,0.021446183,-0.056081414,0.016926184,-0.030412434,0.010932799,0.08638516,0.01212585,0.021848226,0.025213249,0.0026194842,0.0351488,0.027271517,0.019362701,-0.023859393,0.06418364,-0.07853683,-3.5412267e-08,0.0031931098,-0.08003385,-0.004781028,-0.058128078,-0.015589456,0.05269826,-0.030502772,0.02305461,0.11760842,0.06486694,0.046478458,0.09399609,-0.011699095,0.031090798,0.079885736,0.07798284,-0.034045503,-0.002121195,-0.019917123,-0.07427703,-0.027500538,-0.02189976,-0.05413852,0.06440768,0.06932049,-0.04946856,0.009891689,0.051697478,-0.01400496,-0.06954404,0.036864918,0.030669764,0.024057312,-0.01025166,-0.038943656,0.04787302,-0.036803294,-0.0065461197,-0.05898879,0.047822442,0.03423966,-0.045706037,-0.10015486,0.0061511216,0.07094848,0.029770702,-0.07374192,0.06372217,-0.06030187,-0.01174015,0.013297376,0.0025964186,0.010976579,0.0020774342,-0.06170738,0.002407163,-0.052561473,-0.016140107,-0.020915886,0.026392493,0.012885866,0.017620835,0.11937692,-0.0032825428 +7.3.2.5,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the high-affinity import of molybdate and tungstate. Does not undergo phosphorylation during the transport process.",384,1.0,-0.08728992,-0.053337134,-0.02528315,-0.0023050848,-0.064109355,0.00033043302,0.056863755,0.061245706,0.031606868,-0.09277642,0.02815813,-0.032091144,0.012910165,0.108835414,-0.028650885,-0.016548855,-0.035434615,0.026357744,0.031153902,-0.0007563362,0.0067139943,0.06251591,-0.027607482,0.009023218,-0.07181263,0.028296495,-0.014506393,-0.05428502,-0.005250675,-0.023382774,-0.08997824,0.020820465,0.014868188,0.010505149,0.018359704,0.11428078,0.031574063,0.0060148747,0.06899843,0.029898167,0.10896971,0.016819507,0.08933249,0.051012613,-0.11327143,-0.006475523,0.06253487,0.0110268975,-0.036783382,0.010274752,-0.054646757,-0.049433667,-0.056261018,0.060038667,0.0150576215,0.04681154,-0.019876018,0.033742726,-0.0038800472,-0.071681485,-0.03061259,0.020604266,0.12599453,0.111399785,0.028527066,-0.081887156,-0.03614025,0.028217101,0.010038542,-0.03820778,-0.08120177,-0.04286568,-0.04253431,0.06658298,0.013520795,-0.0005345577,0.012173817,0.031955615,-0.0010311687,-0.04973228,-0.0018949022,-0.030332498,-0.0029329238,0.020396702,0.023873296,-0.016328715,-0.020833768,-0.019560931,0.015336032,-0.015018788,-0.0237124,-0.07155745,0.017682409,-0.038903467,-0.13076904,-0.028633267,0.035373036,0.040140033,-0.0012625856,0.010054645,0.036854334,0.063928634,0.022914603,0.008784266,-0.0055313935,-0.042852826,-0.03324557,0.009988656,-0.037630316,0.02561364,-0.01225532,0.05290915,0.063759156,-0.06452258,0.0075496864,0.038067862,-0.044247035,0.011586417,-0.042373776,-0.012664954,-0.0792963,-0.10696328,0.009155359,-0.06766207,-0.044698063,0.03567968,-0.01957495,7.580821e-35,-0.03444641,-0.0656506,0.02578832,-0.025709229,0.01406821,-0.07216579,-0.00624171,-0.08671007,-0.025973363,-0.11423103,-0.016947567,-0.020466438,0.0076126023,0.088344835,0.0071835355,-0.007122815,-0.093186684,0.052817196,0.11428395,-0.0076501267,0.057453204,0.036381844,0.014207216,-0.04343163,0.10622661,0.021621326,-0.016015632,-0.029466601,0.069670044,-0.0027083086,0.020102842,-0.049152676,-0.08420905,-0.021436552,0.040105227,-0.055893507,-0.08425259,-0.042193502,0.03862803,-0.06540657,-0.0767223,-0.050465543,-0.09260036,0.07427902,0.04455472,-0.028493814,-0.026842048,0.065129526,-0.0008375335,0.012098308,0.013581475,-0.1386362,0.07006334,-0.054699995,-0.022771407,-0.00382836,-0.0034587823,0.008617082,-0.0448361,0.061207164,0.062235575,0.1198632,-0.030587055,0.024060298,0.026463022,0.018189082,-0.08867024,-0.117692016,0.047305677,0.115025885,0.0029012847,0.016319461,0.037745588,0.06072189,0.030924628,-0.020610861,-0.01592634,-0.08930986,-0.004095083,0.034172844,-0.0051076873,-0.08154535,0.059260413,-0.004046212,-0.061812557,-0.031980786,-0.01700046,-0.04041104,-0.0005493117,-0.016817117,0.12356692,0.04271145,-0.07712567,0.085105985,-0.0104372045,-1.0920804e-33,0.12005395,-0.028222308,0.12534168,-0.027107427,-0.06413395,-0.00031310963,-0.014021412,-0.005425108,0.028293055,-0.027441068,0.00014204631,0.04872157,-0.0066678096,-0.013861492,0.03232143,-0.08304081,0.014279071,0.022418248,-0.02903003,-0.033540037,0.04591202,-0.0036518453,-0.03046629,0.004396004,-0.06545116,-0.0058198897,-0.061773304,0.059995282,-0.011206598,0.033566575,-0.04420132,0.04449103,-0.009392931,-0.08574696,-0.065000236,0.026767232,0.0034456518,0.046633314,-0.020259345,-0.033926513,0.022240803,0.04970897,0.0008235994,0.037486248,0.020412723,0.11087466,-0.027012413,0.032635562,0.03724419,-0.0005455455,0.0017841166,-0.021438679,-0.012369224,0.008860776,0.055302102,0.08349155,-0.047116008,-0.015440323,0.053147145,-0.088914834,-0.044590216,-0.09318823,0.06381817,-0.014199538,-0.0059162257,0.031635914,0.04467582,-0.045738578,-0.024613725,0.032267958,0.0787125,0.04405344,0.0013519368,0.033426605,0.052473985,0.012589423,-0.038277417,-0.03519923,-0.05287651,0.006655215,-0.049044702,0.06756216,7.80244e-06,-0.013994142,0.11348702,0.022958608,-0.017841835,0.02612066,0.012099193,0.024347583,-0.0037584745,-0.012317114,-0.016353264,0.03284548,-0.013466468,-3.690489e-08,-0.014528281,-0.06512337,0.012211893,-0.079631865,-0.0028887375,0.05408612,-0.028870558,0.037014253,0.10853766,0.036285795,0.05217196,0.10785928,0.007887405,-0.0047932384,0.0811602,0.08089283,-0.05736878,-0.00083301985,-0.022048764,-0.060591742,0.0034022606,-0.032250065,-0.009846464,0.11619622,0.08752715,0.0021038929,0.0056426856,0.08075891,-0.038285803,-0.078924365,0.039286166,0.01988744,0.0032738072,0.019029746,-0.04584033,0.022153996,-0.054673854,0.020708563,-0.08099458,0.096662916,0.013570514,-0.028294483,-0.062069807,0.0342042,0.07685165,0.063269585,-0.07083485,0.069753185,-0.06573579,-0.036293976,0.029290566,-0.015153702,0.011189042,-0.0327813,-0.11724632,-0.009886814,-0.04973812,-0.043942094,-0.04577959,0.021238724,0.0218108,0.015401055,0.13145491,-0.021340078 +7.3.2.6,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, characterized from the archaeon Pyrococcus furiosus, the Gram-positive bacterium Eubacterium acidaminophilum and the Gram-negative bacterium Campylobacter jejuni, interacts with an extracytoplasmic substrate binding protein and mediates the import of tungstate into the cell for incorporation into tungsten-dependent enzymes.",384,1.0,-0.098621346,-0.029436156,-0.053924106,0.019547379,-0.042259198,0.038784504,0.053558398,0.0960805,0.045212973,-0.0533627,0.027948342,-0.08795629,-0.02977605,0.10454597,-0.007091161,-0.021115644,-0.04522019,0.0097125415,0.0012292701,-0.013696242,0.015834386,0.05029733,0.010090936,-0.019714367,-0.07115956,0.03280946,0.039896064,-0.05159747,0.000592308,-0.000100456826,-0.10509747,-0.06691512,0.025794141,-0.0011555991,0.040845156,0.05677328,-0.0023649335,-0.0042443136,0.081485115,0.010964398,0.12983009,-0.008778859,0.06000514,0.046156973,-0.14029464,-0.006275531,0.069827,0.028890664,0.017678026,-0.02636349,-0.051213533,-0.04108713,-0.049232457,0.054239377,-0.02430612,0.02760012,0.01583899,0.018860096,0.009750035,-0.09412039,0.016282829,0.014754855,0.13118419,0.052521292,0.020817058,-0.05511786,-0.034984704,0.03942409,0.016681101,-0.008740805,-0.09689911,-0.049409077,-0.039589167,0.06394277,-0.021368824,0.0041182884,0.006405478,0.03690159,0.011507085,-0.031035017,-0.010425291,8.6800945e-05,0.00442465,0.03361814,0.005571418,-0.009012168,0.0033390722,-0.0015394638,0.054620355,-0.0033765445,-0.041624043,-0.09298631,0.0069863186,-0.03609356,-0.15930408,-0.022786908,0.059563164,0.07334337,0.030154884,-0.015469033,0.04127884,0.047161642,0.0717674,-0.04404731,-0.058757078,-0.05697395,-0.040372066,0.054072298,0.02367321,-0.0024188128,-0.039806776,0.030633261,-0.0045113163,-0.06655571,-0.00987383,0.019049468,0.016733697,-0.010826097,-0.050376687,0.01585024,-0.0086454395,-0.07842992,0.054039214,-0.028985932,0.0025433733,-0.0010759435,-0.023667118,2.1912449e-33,-0.024401713,-0.07434661,0.009119179,0.011683016,0.025269574,-0.07309996,-0.055124074,-0.09886576,-0.04978154,-0.052873597,-0.0832186,-0.0048317877,0.026282694,0.062070694,-0.01543031,0.017992027,-0.12304357,0.058668032,0.08487942,-0.004789457,0.05115735,0.044336203,0.050747775,-0.042730812,0.07722265,0.028499557,0.007687088,-0.03864527,0.019573208,-0.017759884,0.052578513,-0.087274946,-0.11223307,-0.039271098,0.048289325,-0.033020694,-0.08264681,-0.025440156,0.032747976,-0.12271148,-0.05310934,-0.016597364,-0.088994846,0.08759268,0.0777888,-0.06715172,-0.0125470245,0.07477326,-0.005527725,0.032432985,0.007770562,-0.11600595,0.08753125,-0.019169437,-0.012849615,-0.009426379,0.05239928,0.0076888283,0.0058727334,0.058836,0.054027762,0.09923859,-0.053109564,0.01721473,0.042505767,0.012363955,-0.05428661,-0.067894235,0.037664756,0.05601991,-0.00084151456,-0.009525516,0.021954158,0.103106715,0.0024975797,-0.019687489,-0.041575067,-0.08299342,-0.024043642,0.025695466,-0.036902994,-0.056695066,0.068266615,-0.02487371,-0.085303634,-0.020299291,-0.055134557,-0.03514598,-0.02321823,-0.0071805953,0.1194435,0.055132933,-0.10040826,0.07657242,0.01399098,-3.1386478e-33,0.08381859,-0.018855082,0.067622274,-0.050029773,-0.06315313,-0.008765194,0.00272869,-0.006765025,0.0011834556,-0.011749434,0.04832246,0.03988777,0.023202306,0.02720987,0.07994717,-0.05863968,-0.00351485,0.027307117,0.003873109,-0.018051634,0.05321842,0.011426909,-0.057499185,-0.025691973,-0.10091854,-0.0034731405,-0.016148543,0.07225672,-0.007326136,0.03009836,-0.005858229,0.06561252,-0.0033744734,-0.088090375,-0.04802573,-0.038817316,0.008884367,0.040196136,0.0055827913,-0.026565237,0.0673004,0.033708416,-0.024225123,0.03900951,-0.009194055,0.078596614,-0.024410607,0.02650546,0.017422495,0.016373264,-0.013735567,-0.032423045,0.00022059523,-0.019791927,0.040473074,0.07677349,-0.048620466,-0.03449769,0.040487878,-0.058846,-0.047594033,-0.05882248,0.10470188,-0.0016666,-0.035148017,0.0014021595,0.05444333,-0.02732297,-0.011987644,-0.007622079,0.098365285,0.058127973,-0.008029452,0.0042243595,0.023469195,-0.0103139,0.01531567,-0.01742751,-0.028532714,-0.027150283,-0.018075174,0.05682017,0.0030258188,-0.08666046,0.13481288,0.03579144,-0.008934606,0.054868758,-0.010716014,0.014416743,0.044287205,-0.023127913,-0.004384975,0.058034725,-0.011655803,-4.155957e-08,-0.053211764,-0.025311084,0.01629477,-0.058843426,-0.060807694,0.008200086,-0.03633203,0.021437919,0.07981047,0.016804157,0.0860947,0.10066991,-0.020390376,0.023417125,0.062456466,0.07288105,-0.07582016,0.0059097656,-0.008980244,-0.038659424,0.013697446,-0.044205796,-0.003019911,0.06202838,0.07633923,-0.0033823978,0.022541964,0.049509056,-0.035257064,-0.10628854,0.043907717,0.050272774,-0.004028111,0.059842013,-0.038025405,0.039000332,-0.06813015,0.02871154,-0.08462257,0.055064194,0.011564625,-0.010531157,-0.07500523,0.01435257,0.055294454,0.09443889,-0.08156798,0.07939497,-0.070110865,-0.052585904,0.03350786,-0.01711836,0.027451277,-0.041020963,-0.12016104,0.058029946,-0.02610769,-0.018023757,-0.06833472,0.0362085,0.03835493,-0.013190693,0.10907672,-0.03169636 +7.4.2.3,"A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.",384,1.0,-0.10576089,-0.0095370645,0.011447954,-0.002226869,-0.00981534,0.014115802,0.022826638,0.0030828961,0.016118877,0.02488025,0.08544505,-0.03427275,0.028020343,0.019518096,-0.023204952,-0.023809208,-0.03400887,0.033968825,0.04500691,-0.02632683,-0.020464322,0.04091307,-0.02153963,-0.024260024,0.035070106,0.035112694,-0.035434764,-0.011679,-0.015875904,0.042039488,-0.15888326,-0.03114991,-0.023638716,0.0065501863,-0.031130275,0.12664036,-0.088661924,-0.02444101,-0.02415635,-0.029934932,0.1520681,-0.033148933,0.063759334,0.050913546,-0.035067335,-0.043714684,0.027486004,0.033396315,-0.047624595,0.015685057,-0.07362674,0.00092057756,-0.034040295,0.082772546,-0.026078269,0.058706652,-0.04886545,-0.010730219,0.001419116,-0.03243904,-0.0040591313,0.017572917,-0.049058694,0.00292959,0.07900285,-0.09176684,-0.007079708,0.030488607,0.038210668,-0.048341896,0.024538875,-0.03148842,-0.051370505,0.045370456,0.044739913,-0.010296514,-0.0358254,0.040083323,-0.016938647,-0.012220486,0.06513241,0.0080344565,0.055287167,-0.032367524,0.06908272,0.06404808,0.059922043,0.067885734,-0.022171965,-0.0036619494,-0.04775195,-0.035705443,-0.037587475,0.013758434,-0.11631921,-0.015803967,0.03487113,0.051587816,-0.043866076,0.007923243,0.057763167,0.06506801,0.00058662606,-0.013100031,-0.0073332917,0.002598613,-0.029841553,-0.032888047,-0.007923114,0.04204107,0.033384643,0.027173754,0.026181635,-0.055460054,0.035345536,0.09788463,-0.050330367,0.0014142446,0.056259673,0.07385572,-0.045772374,-0.06053844,-0.024642898,0.032660067,-0.019060882,0.015456588,-0.05077468,1.3995932e-33,-0.0135687925,-0.056507967,0.035617344,0.036416464,-0.033197757,-0.071417175,-0.083768904,-0.060480494,-0.009536062,-0.102605134,-0.0037208567,-0.009596037,0.020120107,0.026531475,-0.03968719,-0.08021105,-0.06118755,0.019856105,0.1807361,-0.06924893,-0.04937035,0.10808901,-0.017634599,-0.07041012,0.039066102,0.023242751,-0.06482423,-0.033143453,0.06793133,0.039674565,-0.05695328,-0.05733081,-0.13037136,-0.030064017,-0.04842851,0.0043378687,-0.053747285,-0.12874721,0.026904939,0.033263117,-0.113115326,-0.04139461,-0.04967816,-0.04711912,0.019086624,-0.07599349,0.0022949376,0.007549863,-0.059752855,0.031275924,0.052243307,-0.07601676,0.056190275,-0.08320373,-0.11727988,0.04300734,0.041980896,0.029787926,0.0071839495,0.080176994,0.10872278,-0.011080378,-0.018828534,0.045961525,0.06004107,-0.014983148,-0.092271805,-0.07493859,0.0784282,0.103695765,-0.06678489,-0.027527057,0.059482183,-0.0007398609,0.057458658,0.053671215,0.0032141218,0.031322997,-0.04686014,0.021660356,-0.0024150512,-0.052960616,-0.01234854,-0.026060145,-0.020383779,-0.033153128,-0.0054646386,-0.024100607,-0.02377394,-0.040987033,0.09162745,0.078667045,-0.063730925,0.10216304,0.0127834845,-2.6384689e-33,0.107218936,-0.05703117,0.080964506,-0.051609844,-0.0917011,-0.00026867382,0.049144525,-0.011664861,0.016279083,-0.016524915,0.052877743,-0.07585036,-0.042572323,-0.08459373,0.03377755,-0.04525839,0.0067368606,0.034689333,-0.010963614,0.04340081,0.0349944,0.047233373,-0.032275714,0.10645468,-0.13575272,-0.028577508,-0.032665808,0.046001397,-0.015936747,-0.0025826113,-0.019238986,-0.040985133,-0.00012454766,0.0023378427,-0.064497426,0.023180963,0.05210093,0.07697214,0.043986797,0.027367279,0.09854888,0.060449,0.0064189667,-0.018911898,-0.019343724,0.06976799,0.0010144913,-0.034434542,-0.026654832,-0.024607755,0.08194528,0.0024353915,-0.050348934,-0.03812736,0.0071686455,0.0718738,0.06980303,0.005408159,0.049203735,-0.064469166,-0.04952085,-0.0054133357,0.03218383,-0.041557472,0.035612628,0.08010503,-0.051498253,-0.07612593,-0.025716932,0.033132985,-0.027095107,0.06114176,-0.048543934,-0.047508348,0.0354864,0.009977957,0.057364486,0.03526714,-0.0052766576,-0.060805593,-0.025174623,0.035971582,-0.0039720642,0.0057748663,0.024322612,0.024111964,-0.007737233,0.010235206,0.07612724,0.029572483,0.051800855,0.02861059,0.015571789,0.043029636,-0.013050579,-3.454126e-08,-0.0055575906,-0.027090833,0.018876664,0.005509733,-0.03831741,0.0617272,0.04304304,0.009635463,0.07648087,0.06813754,0.032852624,0.04973816,0.0039760782,-0.0164147,0.05289495,0.04622457,-0.055181816,0.0127547,-0.021874728,-0.072348356,0.024611056,0.012981765,0.021975787,0.13784195,0.03336117,0.00086151937,-0.014750704,0.068199694,0.050531995,-0.09416993,-0.027175942,-0.007063149,-0.033446565,-0.005465459,-0.098767266,0.023692086,0.03137736,-0.02465339,-0.04382544,0.06452677,-0.0016464835,-0.069662094,-0.08393367,-0.04298625,0.01679886,0.046747662,-0.019586578,0.032303523,-0.032452725,0.025833827,-0.023193179,0.03488204,-0.0031294925,-0.064148985,-0.057593122,-0.023931947,-0.044004377,-0.01914226,-0.030230097,-0.059860196,0.07195289,0.019087669,0.10545023,-0.035952013 +7.4.2.4,"A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. Involved in the transport of proteins or preproteins into chloroplast stroma (several ATPases may participate in this process).",384,1.0,-0.033424187,-0.028722344,-0.04012236,-0.011217812,-0.046288114,0.037283167,0.048953407,0.011040572,0.084305905,-0.06740045,0.03679494,-0.05521234,-0.0008107528,0.05921685,-0.06763935,-0.058893617,-0.033707008,0.059205715,0.0153823,-0.056618966,0.011238639,0.070148796,0.0022483957,0.04391108,-0.025441961,0.027451804,-0.04593085,-0.05770325,-0.0054585948,0.013329622,-0.14099084,0.015045063,0.021349823,0.025068533,0.017844884,0.14021406,-0.04269764,-0.038966034,0.022784224,0.023710037,0.10273209,0.041364633,-0.024579702,0.07838213,-0.08016201,0.0038926217,0.044963386,0.012119983,-0.07604424,-0.024162874,-0.05956747,-0.026988914,-0.09142647,0.04806683,-0.018543344,0.07915184,0.018789144,-0.041161638,0.02032229,-0.07421566,-0.019193973,0.0073111625,0.05399999,0.072758384,0.040609322,-0.091275856,0.015147029,0.06462606,0.02296379,-0.031117896,-0.011222584,-0.019921862,-0.035324603,0.06437505,0.02483974,-0.06807636,-0.0077474904,0.04415609,-0.015159246,-0.03399903,0.058189318,-0.017911037,-0.03304454,0.0026084855,0.076995865,-0.024128275,-0.032755826,-0.002618976,0.0074169766,-0.005307752,-0.059603903,-0.047133908,-0.025606515,-0.034779165,-0.08912583,0.0048856805,0.06328145,-0.011688216,0.00338933,0.026841268,0.07360181,0.075018026,0.049722325,0.00942566,0.006726535,0.006882394,-0.07337937,-0.022583406,-0.05091861,0.049743727,0.003270117,-0.020595359,0.024141656,-0.050949946,0.01594666,0.0805413,-0.016641025,-0.016800981,0.0078638755,0.03969298,-0.08812191,-0.07703786,-0.01613865,0.03362076,-0.042565968,0.06283694,-0.09092927,-1.541616e-33,-0.035943147,-0.08569774,0.031352106,-0.0040924456,-0.07139372,-0.00976785,-0.050867416,-0.0654456,0.019274944,-0.08418751,0.024946343,-0.01601303,0.032836843,0.04456915,0.0184546,-0.044845212,-0.059392065,0.09433608,0.12761162,-0.038133454,-0.01857251,0.07775936,-0.03157935,-0.040377386,0.03373981,0.009760987,-0.08564523,-0.046945058,0.07945849,0.011095139,0.004024521,-0.014116428,-0.04310131,-0.037896514,0.030442176,-0.079963975,-0.078875616,-0.0679081,0.03306691,-0.028322916,-0.10563849,-0.07377618,-0.044678997,-0.008108807,0.017769555,-0.077913694,-0.025218567,0.0072943633,-0.0644941,0.041903246,0.054244768,-0.10823528,0.07144973,-0.09926566,-0.08048057,-0.026488042,0.024131222,0.009802379,-0.043980684,0.052921914,0.066030085,0.11722783,-0.079707235,0.020504797,0.012129458,0.011285172,-0.1214093,-0.07775374,0.039684888,0.017377235,-0.062377267,0.0027258687,0.033029914,0.046370022,0.10494001,0.010633587,-0.05703667,-0.016931944,-0.043387745,0.048762053,-0.0061681424,-0.05146198,0.018114025,0.009167192,-0.049864992,-0.018772315,0.01326819,-0.008126534,-0.032870036,-0.035561025,0.118926786,0.054175477,-0.10473659,0.097261116,0.079918295,-1.7041795e-33,0.061037444,-0.050148446,0.08471817,-0.07713177,-0.03457721,0.011885263,0.008724892,-0.046342902,0.05278054,-0.03810007,-0.037057232,-0.0009279938,-0.053363066,-0.04232268,0.011448327,-0.03427095,-0.016134217,0.049984273,-0.031514812,0.057021197,0.027425183,0.019292893,0.00819488,0.101423524,-0.07693813,-0.014243985,-0.06847788,0.05698806,0.011748179,0.02406493,-0.00791836,-0.009245883,-0.009348258,-0.036000647,-0.10303761,-0.0015558616,0.057351287,0.05944729,-0.034032192,-0.005759803,0.052489497,0.09221365,0.056258094,0.019603316,-0.0033252425,0.10286754,-0.028842153,0.022932205,-0.031806964,-0.018480942,-0.01893673,0.055505693,-0.047378927,0.010216671,0.054389317,0.07646145,-0.04162995,0.014663273,0.07166217,-0.086497076,-0.036774155,-0.068060115,0.018932903,-0.029859057,0.043426473,0.015962223,-0.011564941,-0.008272086,0.008116149,0.04486705,0.03775056,0.08270888,-0.056822997,-0.065556906,0.036519896,0.0013726101,-0.015016776,-0.029218739,-0.019266468,-0.08042642,-0.07408976,0.067741014,-0.0067416243,-0.0018787947,0.06750943,-0.04858323,-0.02200341,-0.037342012,0.029776592,0.015111691,0.03471338,-0.0161374,-0.009053497,0.04616013,0.023460733,-3.100693e-08,0.030831087,0.00487977,0.0243897,-0.05158219,0.047701318,0.026989264,-0.0062206807,0.007905908,0.12384633,0.069728024,-0.0056865322,0.0034498554,0.037710506,-0.04904983,0.030183071,0.09658246,-0.053184286,0.031194165,-0.0051717735,-0.054144364,0.024264257,0.0051877783,-0.06893726,0.13873279,0.062087584,-0.04275871,0.072837204,0.037009418,0.006797499,-0.10586002,0.039523248,0.018366635,-0.0038306597,-0.018916123,-0.039043136,0.035032213,0.020875568,-0.013892713,-0.1071094,0.05006968,-0.03511039,-0.008272196,-0.06489602,0.017040739,0.020358559,0.06061566,0.006657974,0.030057034,0.009677524,-0.0062558358,0.039047677,0.0048169713,-0.025914194,-0.04662423,-0.078573786,-0.009280748,-0.0038695775,-0.04567767,-0.05897316,0.019615347,0.06680655,0.032017455,0.14784405,-0.013224118 +7.4.2.5,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This entry stands for a family of bacterial enzymes that are dedicated to the secretion of one or several closely related proteins belonging to the toxin, protease and lipase families. Examples from Gram-negative bacteria include alpha-hemolysin, cyclolysin, colicin V and siderophores, while examples from Gram-positive bacteria include bacteriocin, subtilin, competence factor and pediocin.",384,1.0,-0.0946046,-0.08326994,-0.039093874,-0.051356696,-0.07744395,0.02327518,0.031073196,0.10597437,0.07637465,-0.09430581,0.040825125,-0.061780687,0.0276713,0.12360266,-0.03142934,-0.057827838,-0.03779319,0.03315558,0.03133356,-0.028911393,1.4151773e-05,0.12214159,-0.033545397,0.03617788,-0.09163096,0.027002567,-0.011983636,0.0044965157,-0.011910002,-0.027592244,-0.07021892,-0.017163677,0.023088844,-0.00879201,0.04107986,0.08099685,-0.046998527,0.0010371314,0.09772549,0.03718613,0.0764972,0.00743357,0.059605315,0.054018334,-0.12598687,-0.014349985,0.045303896,0.03136128,0.00946071,-0.024998125,-0.005055145,-0.016487814,-0.05329634,0.06250022,0.02077261,-0.0023982169,0.00044656784,-0.035040267,-0.03716752,-0.024274996,0.0010657944,-0.009898908,0.06795027,0.065279074,-0.0026343255,-0.02931139,-0.05782439,0.029708445,0.023986505,0.008676649,-0.1014416,-0.09549012,-0.03615924,0.09526202,0.027305253,0.01599733,-0.025956249,-0.00016994296,-0.046763364,-0.07128072,0.0121670915,-0.022581885,-0.028047105,0.051536053,0.037323304,-0.05257362,0.030540248,0.009551118,0.00017471559,0.035211105,-0.0072178342,-0.048086096,0.07642416,-0.054880396,-0.116225004,-0.011910748,-0.038656086,0.0036468066,0.0020853456,-0.0047228476,0.025621204,0.032946873,0.058646876,-0.0169416,0.008193623,-0.031353764,-0.00691493,0.019599715,-0.000583676,-0.0057477173,-0.030070985,0.018257836,-0.016985703,-0.09806259,-0.019003846,0.04163377,0.010587401,0.027518954,-0.010889417,0.010205365,-0.076726176,-0.093863204,0.017360061,-0.037987348,0.0059734434,0.01900132,-0.084077954,1.5490283e-33,-0.079261586,-0.04865957,0.046760798,0.002244087,0.004178715,-0.027854426,-0.044844378,-0.0497992,-0.0072171134,-0.040235948,0.014329279,-0.024387512,0.008546403,0.094114155,-0.002418902,-0.02408196,-0.10566637,0.04898956,0.08470672,-0.03657385,0.039372284,0.05865393,0.03730706,-0.07323802,0.11223474,-0.006639735,-0.043148816,-0.025300596,0.050940678,-0.020893238,-0.0071398835,-0.012561218,-0.07297321,-0.043715805,0.042299744,-0.050906334,-0.045497887,-0.02709102,0.057817355,-0.048109196,-0.10418636,-0.03161167,-0.07208815,0.04032447,0.08704793,-0.030085003,-0.024395118,0.058244485,-0.03517655,0.031873483,0.07457563,-0.13862844,0.035283517,-0.08296555,-0.017060496,-0.028360035,-0.0039302427,0.07317352,-0.055384763,0.06842974,0.10184084,0.13985251,-0.08073269,-0.02060232,0.007980219,0.028668297,-0.06751991,-0.12740378,0.050937314,0.09332903,-0.01366425,0.04513263,0.023478264,0.045264482,0.04693397,0.02829675,-0.08195354,-0.044801075,0.011259922,0.023962,-0.08663617,-0.052370757,0.038710196,-0.00060887996,-0.09075411,-0.036782593,-0.025251921,-0.021987062,0.011270005,-0.028501844,0.12436324,0.036641654,-0.06810164,0.13439763,-0.009182192,-3.362411e-33,0.06626942,-0.046577875,0.08700471,-0.044512633,-0.032439515,0.0069160825,0.016917558,0.031234188,0.03527201,0.01428388,-0.00916132,0.061504774,-0.012883561,-0.031534668,0.022751212,-0.07330601,-0.047822062,0.0066640265,-0.028354244,-0.023910256,0.004112767,0.047276318,0.016630976,0.03616727,-0.050740797,0.019595517,-0.033100314,0.10005733,0.0013381545,0.0414384,-0.023236496,0.070248075,0.004707967,-0.0376116,-0.08024726,-0.0029524448,0.0025494979,0.043418333,-0.010283547,-0.024551874,0.027133651,0.07836642,0.008522499,0.024713365,-0.022605734,0.077986114,0.023942696,0.03472542,0.019720163,-0.033393253,-0.02598768,-0.014228617,0.0087839905,0.015214878,0.042322952,0.07943435,-0.049994465,-0.025390163,0.059671134,-0.036216386,-0.049193006,-0.05736079,0.05515254,0.008724754,-0.0012595961,-0.0335162,0.007517171,-0.06616709,-0.0063868146,0.044262923,0.08829488,0.028359208,-0.02720459,-0.024082782,0.021746974,0.037624154,-0.024709616,-0.08179725,-0.06334734,0.018992672,-0.049294848,0.04423384,-0.047581445,0.023574157,0.088291325,0.029912269,-0.022209179,0.00045620953,0.023283292,0.027059177,0.035257183,0.013403288,0.0060693487,0.06309828,-0.031745847,-4.3315175e-08,0.028980047,-0.04241286,0.040208187,-0.05338813,0.011445816,0.011615603,-0.057893194,-0.0015982047,0.10751433,0.06448475,0.0141921155,0.0822622,-0.036320474,0.035288706,0.046521768,0.08888338,-0.056547616,0.00719213,0.0032361744,-0.061506193,-0.013967911,-0.05209829,-0.056775123,0.085579395,0.047173027,-0.07144212,0.026942814,0.040828545,-0.028739499,-0.059493452,0.057315912,0.015452287,-0.013625972,0.017305845,-0.02706211,0.051911257,-0.066412516,-0.030021623,-0.05806841,0.08363132,0.04391934,-0.056432765,-0.10476384,0.005990383,0.05654914,0.06747545,-0.04184717,0.063333206,-0.06437344,-0.042470653,0.050052315,0.0050358786,-0.021243105,-0.008865182,-0.066480935,0.043253053,-0.055085696,-0.036863133,-0.022673545,-0.0033477005,0.030157102,0.012974786,0.16836418,-0.011541384 +7.4.2.6,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of oligopeptides of varying nature. The binding protein determines the specificity of the system. cf. EC 7.4.2.9, ABC-type dipeptide transporter.",384,1.0,-0.072950885,-0.076171495,-0.0114959255,-0.016439702,-0.051893447,-0.005817962,0.067469195,0.087102406,0.062276594,-0.07758089,0.02839092,-0.040126286,-0.015135415,0.1130075,-0.004341189,-0.039419647,-0.07207676,0.0025142764,0.041766886,-0.015103125,-0.004891578,0.09742713,-0.055889968,0.02000232,-0.07016342,0.0045347936,0.013457762,-0.03624393,-0.022430917,-0.042156264,-0.061028548,0.015306473,-0.005031779,0.008470954,0.046393465,0.08373217,-0.018332025,-0.013758418,0.09017454,0.031476464,0.13750814,0.0045321183,0.08785727,0.04807079,-0.12643659,-0.0038333936,0.05856854,0.034975883,0.02130518,-0.010120816,-0.038445167,-0.04491571,-0.044333305,0.070517704,-0.009968246,0.056261983,-0.02497623,-0.036844693,-0.014599949,-0.060612258,-0.03700095,0.017052311,0.10862029,0.09059411,0.02175711,-0.04220321,-0.04823206,0.016288726,-0.0023482218,-0.023430452,-0.08000799,-0.04351404,-0.03987372,0.07654366,0.06488555,-0.047731526,-0.022821663,0.053755872,-0.03444454,-0.045135103,0.001727308,-0.047705192,-0.039690126,0.025786646,0.033166874,-0.018607393,0.0041923807,-0.032605913,0.014223519,0.002361714,-0.013403501,-0.08355974,0.042582735,-0.05990307,-0.121377826,-0.026018418,0.0006935808,0.027547942,0.021051483,-0.0024891698,0.03725338,0.049985614,0.027542459,0.023076575,-0.0048692035,-0.038041927,0.032045934,0.0049147042,-0.022925334,0.00012691147,-0.01366106,-0.005934363,0.046101786,-0.10829035,-0.032969724,0.040942725,-0.039715596,-0.009797049,-0.028842004,-0.02429877,-0.058351047,-0.10312696,0.04433551,-0.040594053,-0.0074582445,0.05086213,-0.06488301,-3.0098942e-34,-0.064419456,-0.06933597,0.058442473,-0.015142227,-0.008961257,-0.056257073,0.005726063,-0.0565468,0.004692994,-0.07763454,-0.03778869,-0.028218964,0.014313372,0.12554996,-0.00047454174,-0.0069214264,-0.09759465,0.07253764,0.09630687,-0.01896707,0.051214926,0.022386702,0.023943255,-0.015715031,0.106300145,0.0070300414,-0.047838446,-0.016440634,0.06867614,-0.019326685,0.0436802,-0.033712424,-0.10748058,-0.016823674,0.038578648,-0.07216124,-0.013621661,-0.04893905,0.051660214,-0.062485497,-0.10519557,-0.030208647,-0.061004814,0.06527332,0.0781803,-0.05307091,-0.015924545,0.03634629,-0.026854448,0.02828433,0.045615185,-0.12726532,0.09187359,-0.07585716,-0.0040240963,-0.024951786,-0.017910529,0.022513568,-0.024944503,0.07477779,0.042681795,0.12812167,-0.059323166,-0.00809293,0.032378513,0.07850214,-0.04940845,-0.10653558,0.03381381,0.09173951,-0.011446019,0.029110953,0.017606005,0.061184924,0.041320287,0.010590045,-0.12204123,-0.054990113,0.019828975,0.01669263,-0.026123561,-0.08280149,0.039842922,0.017296916,-0.07958471,-0.036261104,0.034370806,-0.037674055,0.040236853,-0.01334525,0.11743109,0.06729525,-0.08073278,0.10969591,0.032893695,-7.134361e-34,0.08909833,-0.0382851,0.07595314,-0.057804197,-0.044774037,0.00043928303,0.0022720792,0.0057676192,0.03528503,-0.035769172,-0.015732316,0.06630992,0.026240481,-0.03234116,0.017416129,-0.07657473,-0.08088305,0.042449225,-0.031071011,-0.025560305,0.012812664,-0.015633216,0.031183764,0.009505942,-0.03691545,0.009058038,-0.049545053,0.08874341,-0.0101796845,0.022374513,-0.041094027,0.06193285,0.008125825,-0.039332617,-0.046482015,0.053085577,0.00695825,0.036126778,-0.016130742,-0.014998554,0.008429155,0.04536486,0.012810882,0.02251332,0.008472854,0.08679312,-0.005279596,0.07194689,0.029416265,-0.027017752,-0.01402075,-0.00030290437,-0.0032179565,0.0138201015,0.067346,0.087848336,-0.027541425,-0.02498047,0.07861655,-0.096448064,-0.03622537,-0.10329534,0.07242757,-0.019496,0.017956369,-0.03127307,0.030488502,-0.051623106,-0.021416893,0.055916138,0.0762678,0.0054372083,0.018640624,-0.0003579019,0.05403676,0.04051169,-0.017766755,-0.031055305,-0.03693758,0.031218296,-0.06481753,0.030302443,-0.016036894,-0.0123455785,0.09266728,0.027006542,0.0035036956,-0.0074213822,0.0042303577,0.0294504,-0.005411809,-0.010888507,0.034615315,0.05305766,-0.028889073,-3.988817e-08,0.02509044,-0.03329698,0.009869092,-0.06487493,0.0051364903,0.029064741,-0.047922134,-0.011255588,0.06881128,0.06257958,0.041807864,0.10617053,0.015768671,0.017935459,0.08802094,0.05447332,-0.02838815,0.007933809,-0.011925004,-0.06338614,-0.003861252,-0.04050255,-0.025930211,0.07698115,0.08271633,-0.02972076,0.004377437,0.044126216,-0.038157243,-0.05318555,0.04809789,0.017498603,-0.007708863,0.0015138307,-0.009716119,0.056661155,-0.060522493,0.0037566382,-0.057003986,0.094617955,0.0014713116,-0.03662239,-0.118320376,-0.013098634,0.052313063,0.058987565,-0.042167753,0.066120945,-0.09841852,-0.02982602,0.020877192,-0.0443682,0.02150837,-0.0056383414,-0.080430545,-0.03490976,-0.07459935,-0.017587228,-0.018626941,0.0124820685,0.030458366,0.06257229,0.12747838,0.0015905292 +7.4.2.7,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports the alpha-factor sex pheromone.",384,0.99999994,-0.051972684,-0.05797592,-0.022519791,-0.010080706,-0.06632923,0.03626428,0.0797561,0.0140579175,0.05012293,-0.038616948,0.03141298,-0.05664053,-0.082236275,0.08673761,0.008923151,-0.040029153,-0.0506553,0.030619465,0.040257808,-0.0061988607,0.022206923,0.068341054,0.0015857943,0.012923259,-0.088669695,-0.017494064,-0.011428869,-0.056539055,-0.040581495,-0.039392777,-0.092740156,0.038604856,0.014764778,0.031502448,-0.05937677,0.11591237,-0.0075589363,-0.021122629,0.07882668,0.05633398,0.11318124,-0.032565076,0.05199441,0.07459753,-0.157477,0.020298643,0.04413087,0.018295227,-0.0071398453,-0.0052816384,-0.011241093,-0.054010246,-0.059702165,0.058556788,-0.02617284,0.06782462,0.0005427012,-0.0065409048,-0.0043002567,-0.010527245,-0.048806682,0.023733621,0.04868945,0.09679476,0.07240382,-0.051094394,-0.060581435,0.035311293,0.002092553,-0.0047020093,-0.055805326,-0.049963117,-0.11676724,0.058256466,0.069573835,0.020076215,-0.016579924,0.003814914,-0.00795684,-0.042193934,-0.011436652,-0.039726395,-0.009342209,0.023247553,0.042401247,-0.027735751,0.00030326776,-0.009598546,0.0017282116,0.035420287,-0.062016804,-0.02962058,0.038997866,-0.003979065,-0.09841041,0.026277427,0.005248122,0.03475186,-0.002112559,0.01609156,0.05483235,0.08536883,0.036812726,0.009756721,-0.0065545184,0.018943477,0.0018756107,-0.01947634,-0.032542437,0.038855806,-0.03282292,-0.013373907,0.03578799,-0.080250435,0.013363096,0.011248274,-0.043077897,0.022506403,0.036390595,-0.013183588,-0.05178088,-0.07176063,0.017104987,-0.024945492,-0.02824956,0.0064560454,-0.06212874,-1.5323913e-33,-0.09738403,-0.041366026,0.018284205,0.022331282,-0.02418573,-0.0052929455,0.0075931824,-0.07267215,-0.017340839,-0.11094439,-0.015153876,0.051896308,-0.045718655,0.12676182,0.013628985,-0.038852196,-0.017947135,0.065489,0.09499808,-0.034818053,0.035197794,0.06982627,-0.022355014,-0.06003367,0.092364386,0.010155003,-0.06605152,-0.006781546,0.03139236,-0.016193071,-0.001843654,-0.026369996,-0.082086734,0.009311745,-0.0022594298,-0.06750656,-0.045039754,-0.030444216,0.029863264,-0.07122633,-0.10664156,-0.059037276,-0.08292051,0.060527936,0.009293438,-0.05244682,-0.031955812,0.024679499,-0.005681744,0.022824546,0.005962595,-0.11116617,0.077574775,-0.033926256,-0.021721467,-0.031837475,-0.010632908,0.018978687,-0.07506478,0.055939402,0.042564344,0.16324222,-0.007027409,0.031844735,0.0042924383,0.0021041534,-0.083551906,-0.13768546,0.01895017,0.11592135,0.004181487,0.055731256,0.052198112,0.01816996,0.07688734,0.011030671,-0.062878124,-0.06588485,-0.054686066,0.030080022,-0.033086505,-0.09147682,0.051858135,0.040240306,-0.085211605,-0.040667526,0.03764548,-0.016141936,0.011559413,-0.04880431,0.08856902,0.018302828,-0.030867497,0.0957565,0.051291432,2.3428333e-34,0.08057941,-0.022224138,0.10594453,-0.04686279,-0.05468767,0.030777136,0.06716627,-0.03849699,-0.022771034,-0.0024348442,-0.0140857,0.019249009,-0.0008292132,-0.0612239,0.05972586,-0.08550468,-0.024499852,0.03870251,-0.008845502,-0.013302464,-0.006330135,0.053605728,-0.033706553,0.07762512,-0.039665055,-0.026639186,0.0139013305,0.08833607,-0.011929222,0.022168497,-0.03365107,0.04347508,0.016357949,-0.044661213,-0.014824797,0.027894782,0.0061195414,0.0695338,-0.023001617,0.022115264,0.028550485,0.06090211,-0.004950632,0.011419327,0.019358028,0.09792982,-0.0053836606,0.07403843,0.03339272,-0.003930025,0.03119145,0.014922424,-0.0499439,-0.022882197,0.05515481,0.10707959,-0.00910269,-0.011763615,0.05993766,-0.054060884,-0.04919644,-0.06584912,0.05975927,-0.019944498,-0.03141563,-0.04667323,0.018381264,-0.06677538,-0.03660688,0.118154846,0.13414045,0.070310794,-0.00012332168,0.043879632,0.047741547,0.015521248,-0.01667343,-0.051897064,-0.055984292,0.010145823,-0.022536423,0.038874302,0.019340964,0.02031732,0.0917716,-0.018277438,0.0015858928,-0.011050617,-0.025222654,0.03407563,0.049717423,-0.022161216,-0.03524096,0.063483104,-0.032182608,-3.1966177e-08,0.008877804,-0.020267943,-0.0002399304,-0.09602285,0.0010088322,0.035861775,-0.015990665,-0.039693553,0.0941801,0.06276149,-0.02495841,0.0798135,0.03766501,0.06485731,0.09937444,0.026072334,0.00044290585,0.022439284,-0.024648268,-0.07545042,0.008923492,-0.030761234,-0.07359809,0.0633305,0.048459783,-0.015680728,0.03926513,0.073000945,-0.005121571,-0.06363439,0.07073171,0.018933872,0.00086332054,-0.00015047439,-0.015694251,0.09282977,-0.042971157,-0.026324686,-0.07875878,0.06233295,0.0034409848,-0.06426922,-0.061164703,0.019028392,0.043366358,0.03383176,-0.011805766,0.02228203,-0.026826836,0.024068449,0.028596371,0.051427197,-0.02572164,-0.063724145,-0.0761939,-0.05848974,-0.07583457,-0.038931154,-0.014824587,-0.014081593,0.06396858,0.0096467,0.12886637,-0.06808422 +7.4.2.8,"A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. There are several families of enzymes included here, e.g. ATP-hydrolysing enzymes of the general secretory pathway (Sec or Type II), of the virulence-related secretory pathway (Type III) and of the conjugal DNA-protein transfer pathway (Type IV). Type II enzymes occur in bacteria, archaea and eucarya, whereas type III and type IV enzymes occur in bacteria where they form components of a multi-subunit complex.",384,1.0,-0.037760302,-0.06350186,0.012327987,-0.027291697,0.012670718,-0.033017218,-0.02630009,0.021503922,0.067050785,-0.053620268,0.05159636,-0.059829004,-0.021727368,0.07120387,-0.015925521,-0.075991094,-0.06630858,0.033877205,0.026077446,-0.041144546,0.06842409,0.0639101,-0.027377762,0.024514422,-0.04257091,-0.0026156032,0.025569638,-0.015644094,-0.005470788,-0.043933295,-0.13551877,-0.052709647,-0.031149948,0.01599508,0.049915574,0.075792395,-0.07438278,0.024052896,0.08853118,-2.9610912e-05,0.104666665,0.032342862,0.07580304,0.05832489,-0.08583744,-0.034247845,0.003230596,-0.0060659293,0.016722683,-0.041235093,-0.05827992,-0.04287482,-0.04302293,0.0786338,0.014686093,0.02011573,-0.039095666,-0.034679737,-0.043447826,0.03506146,0.045197975,0.026922315,0.04566763,-0.018238228,0.023467444,-0.024680147,-0.006195066,0.016069274,0.048966467,-0.043755762,-0.0799122,-0.07088429,-0.062764846,0.036247455,0.014930655,-0.015734153,-0.03601768,0.054778833,-0.03421076,-0.069512516,0.02074109,-0.043088347,-0.004236824,0.052905004,0.046384685,-0.035078492,0.03636242,0.004413828,0.029515887,0.03742345,-0.059312917,-0.0714177,0.06708784,-0.040552724,-0.046540704,-0.026053622,-0.008055485,0.02931126,0.020345546,-0.013032139,0.04674743,0.024375318,0.029112922,-0.028827146,0.0105762975,0.03337205,-0.021591756,0.004401366,-0.008645115,0.057566267,-0.02607242,0.052159514,0.025230046,-0.06531442,-0.008836222,0.0824405,-0.040090647,0.006502108,-0.020428032,0.042607095,-0.00016508995,-0.077281795,0.037941273,-0.014774561,-0.07454251,0.01686233,-0.07435848,-6.393561e-34,-0.06857463,-0.057735223,0.017939746,0.018515643,-0.03744377,0.013659784,-0.03705424,-0.027621692,-0.050561428,-0.04281374,-0.02045152,-0.07917791,0.015656278,0.053657968,-0.0035086805,-0.019760147,-0.04516023,0.03056867,0.04262802,-0.040923472,0.074586794,0.10124485,-0.0012780451,-0.042925972,0.085588746,-0.0064051007,-0.0025662952,-0.007927154,0.048136726,-0.002497366,0.053701904,-0.15155709,-0.077716365,-0.0057086004,0.03428369,0.00064869487,-0.038285885,-0.05127811,0.065209016,-0.046368953,-0.07264177,-0.015203801,-0.028528642,-0.01340907,0.0726733,-0.05581665,0.00029319443,0.06181958,-0.027541408,-0.0007205251,0.026454188,-0.11477996,0.054280646,-0.07422795,-0.046437364,-0.048599485,0.055526897,0.08264002,-0.0016744777,0.06323397,0.051933415,0.07634116,-0.05569512,-0.014214027,-0.024476498,0.066684045,-0.09793198,-0.07758375,0.058503203,0.11652092,-0.06985682,0.018402072,-0.004882531,0.049113136,0.058687575,-0.034808565,-0.10449131,-0.047192175,-0.0030832884,0.0686506,-0.10926552,-0.053666193,0.06492379,0.067904666,-0.0766546,-0.024677806,-0.056618396,-0.013618924,0.0492642,0.008361968,0.13470021,0.053892966,-0.05280987,0.10148385,0.040473446,-1.8264644e-33,0.070667565,-0.02637997,0.07330652,-0.1342353,-0.048497003,0.03949926,-0.020493105,-0.0042188675,0.045828406,-0.012224922,-0.006638714,0.007012232,-0.00914376,-0.072844215,0.013184857,-0.06313247,-0.013530733,0.080534644,0.01393429,-0.008425511,0.033449385,0.037278228,0.025070444,0.04540078,-0.038730413,0.017872507,-0.045446157,0.15468402,-0.029906932,0.04835921,-0.06576432,0.07093348,0.022225015,-0.012713565,-0.08116152,-0.02586585,0.0036273235,0.024857054,-0.025400402,0.0019729978,0.020387178,0.108717896,0.08404099,0.016778337,-0.0371623,0.10209926,0.009774758,0.03492954,-0.0220831,-0.009589323,-0.0018836285,-0.03779582,-0.033954646,0.009621874,0.046493705,0.080999635,-0.04056507,0.028023684,-0.0023659673,-0.006861887,-0.048389513,-0.09481921,0.055879742,-0.0073935636,0.035145517,-0.04077725,-0.050350454,-0.0029663634,-0.00845225,0.01972846,0.025572618,0.064490624,-0.037140526,-0.04036408,-0.006587668,-0.029598938,-0.042497464,0.029016027,0.024114002,-0.048399247,-0.0015582173,0.044953115,0.00029203805,-0.007903218,0.07433734,0.0055851447,-0.0061325254,0.038461413,0.021391867,0.053862024,-0.0276575,-0.001301448,0.0007620943,-0.0053532603,0.033331662,-4.0585576e-08,0.054873124,-0.024862804,0.055145472,-0.051614504,0.0017349909,0.04397874,-0.07366361,0.065525785,0.083469436,0.08778831,-0.03150088,0.01684061,0.04707059,-0.042783506,0.029554734,0.0868515,-0.036475964,0.03279666,-0.041763276,-0.034991276,-0.00441852,-0.05983556,-0.08746453,0.10769767,0.02017073,-0.010660241,0.025849342,0.024040386,-0.038952015,-0.0595243,-0.015291496,0.016760206,0.016615456,-0.022472514,-0.097320504,0.044273894,-0.015206944,-0.043560535,-0.07158286,0.037189998,0.04828298,-0.0763541,-0.076972075,0.009988643,0.085938945,0.06440394,0.010213554,0.025016923,-0.028149169,-0.030496085,0.04151184,-0.015116864,-0.0013867574,0.0075653144,-0.077498965,0.020248933,-0.035159413,-0.06580379,-0.023580343,-0.010446514,0.09820996,-0.0071325456,0.22154824,-0.055776093 +7.4.2.9,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of di- and tripeptides. The enzyme from Pseudomonas aeruginosa can interact with five different substrate binding proteins.",384,1.0,-0.087429576,-0.08245497,-0.014779389,-0.032237977,-0.07378318,0.019961704,0.031587493,0.10433362,0.03709518,-0.07400613,0.053260513,-0.059513927,-0.006054281,0.13368301,-0.0051932763,-0.039178234,-0.06848249,0.034781694,0.03803802,0.010421985,0.020117521,0.11673619,-0.09649065,0.023714026,-0.07461734,0.052055333,0.044164114,-0.0032972756,-0.0056382865,-0.018734174,-0.10847789,-0.036367238,0.03058322,0.008953598,0.017874962,0.07699192,-0.017075885,0.018341959,0.1277075,0.019628916,0.12775801,0.016091257,0.09125077,0.0070042335,-0.10154212,-0.04312369,0.025487585,0.05957943,0.03404229,-0.017852828,-0.02389104,-0.015436225,-0.030043032,0.07808907,-0.014852278,0.061374437,0.020454172,-0.018380716,-0.021207567,-0.064468004,-0.025818959,-0.0067313206,0.07535901,0.08735449,-0.003701865,-0.05209427,-0.05559125,0.045961294,0.022528851,0.014863259,-0.0801962,-0.054855153,-0.009273994,0.061382007,0.04968432,-0.060048115,-0.032489568,0.0188928,-0.03921412,-0.046188314,-0.0016144743,-0.04335812,0.0095085995,0.049561284,0.026009405,-0.051408987,-0.0073333685,-0.0009248722,0.034711946,0.0061000586,-0.0024499993,-0.058849387,0.018263265,-0.04720618,-0.11881795,-0.0076401574,-0.021638514,0.014326582,0.0117663,-0.02865183,0.036171727,0.04629148,0.016791662,-0.02477791,0.029538466,-0.0021440133,0.008984494,-0.003113373,-0.008011355,0.0034319565,-0.011099877,-0.0033107882,0.023604997,-0.071275234,-0.01922157,0.03753046,-0.0064097345,-0.01447532,-0.057243336,-0.004972438,-0.057194903,-0.11467359,0.03047261,-0.026341284,0.0045221746,-0.011133164,-0.08012168,5.52655e-34,-0.08023693,-0.069288895,0.004075323,-0.01294186,0.011424862,-0.042171903,-0.01823239,-0.03595132,-0.020142626,-0.081233785,-0.0034414108,-0.015879441,0.027948467,0.10740191,-0.023485404,-0.0007891402,-0.09386372,0.06897634,0.089943275,-0.02141382,0.07070924,0.018219413,0.02053374,-0.045243934,0.12337139,0.0078105135,-0.0040950202,-0.0017426107,0.061349176,-0.018639887,0.028028572,-0.042879865,-0.09649425,-0.024650598,0.067716606,-0.0363299,-0.010914648,-0.00739985,0.03913078,-0.016299648,-0.07784267,-0.05411107,-0.08027877,0.061855417,0.056370273,-0.040980525,-0.017718107,0.066773124,-0.046440255,0.037005603,0.07037501,-0.16486466,0.043049887,-0.046190247,-0.02398656,-0.027097434,-0.03307875,0.030885462,-0.016067108,0.06721117,0.09348639,0.11608091,-0.053605903,0.023026139,0.035330065,0.046548236,-0.040097877,-0.11161122,0.040841565,0.08941184,-0.025852425,0.01783347,0.028310448,0.07332355,0.022208408,-0.014180958,-0.09998876,-0.030137142,0.030178633,0.060248185,-0.04676246,-0.077237666,0.042061113,-0.0058538327,-0.090274945,-0.03950042,0.013827111,-0.05567247,0.00677062,-0.07074423,0.14765689,0.0150575265,-0.08105794,0.120739155,0.036872234,-1.7909207e-33,0.08040527,-0.029241623,0.109796874,-0.026139267,-0.05267352,-0.021018827,0.014205354,0.03711628,0.053338006,-0.023279304,0.0035070896,0.070583,-0.020589782,-0.026566112,0.04285276,-0.028806511,-0.033169974,-0.008152161,-0.028232832,-0.06360189,0.032795556,-0.022915307,0.00080723903,0.02988483,-0.06315777,0.020151252,-0.038661584,0.082620785,0.010670446,0.057484314,-0.038199008,0.058107235,0.021764494,-0.050369818,-0.052537497,0.06706654,-0.016004454,0.047913868,-0.013302732,-0.039558683,0.052243657,0.058254994,-0.0032690184,0.059751544,-0.028354105,0.08726598,0.009660787,0.04952511,0.0144475065,-0.06250501,0.006952309,-0.020234888,-0.004187427,0.025760505,0.039126664,0.07657288,-0.033464547,-0.018369665,0.04876323,-0.06477561,-0.03254167,-0.08395557,0.053720728,-0.02436285,-0.012358129,-0.027835697,0.021156617,-0.042862967,-0.04349966,0.06621443,0.079273775,0.027052911,0.0067629204,-2.9768338e-05,-0.005717354,0.037731595,-0.023871955,-0.04973858,-0.057503738,0.0398912,-0.03899645,0.04637948,-0.043777727,-0.009956992,0.09268031,0.028712578,-0.00927983,0.026684472,-0.025862813,0.04726916,0.034936603,-0.010025591,0.06466157,0.06910779,-0.03369507,-3.5680475e-08,0.016184239,-0.030815113,0.042043056,-0.061225183,-0.030981367,0.037053984,-0.060470603,0.008805163,0.068619296,0.036837272,0.0060824584,0.06804196,-0.023596317,0.055484265,0.06427023,0.06967683,-0.07904886,-0.010591458,-0.019435395,-0.09124381,-0.02003233,-0.05042558,-0.046071347,0.049291205,0.08251389,-0.013501961,0.024130182,0.040760856,-0.02317189,-0.05986184,0.021495815,0.00942674,-0.043297384,0.03228453,-0.03773191,0.021620084,-0.04849076,-0.03794809,-0.07333977,0.049721636,0.051383946,-0.06422038,-0.0971117,-0.012238313,0.051376637,0.042077266,-0.04261801,0.06617957,-0.03515158,-0.03889996,0.03731035,-0.025497079,0.008005675,-0.016340502,-0.08439742,5.6265367e-06,-0.07518083,-0.024432749,-0.03470034,0.038055435,-0.011516244,0.029165175,0.12909228,0.0059784297 +7.5.2.3,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. An enzyme found in Gram-negative bacteria that exports beta-glucans.",384,1.0,-0.10989664,-0.069402106,-0.014359696,-0.024715377,-0.105450526,0.007556135,0.047371466,0.07496623,0.073682934,-0.06316631,0.064798474,-0.034277342,0.0034176179,0.100526035,-0.050775222,-0.0675394,-0.030077392,0.033059716,0.03111029,-0.03183327,-0.012078782,0.12354217,-0.0450783,0.0055273515,-0.053253878,0.030833803,-0.0040509347,-0.06702217,-0.018989727,-0.024033163,-0.09172542,-0.033236355,0.025845727,0.028738733,0.0058603706,0.08952495,-0.038191322,0.003938926,0.09181173,0.029216357,0.089298494,-0.023797272,0.073323704,0.04767065,-0.12337796,-0.010758067,0.050534543,0.03894204,0.033693474,-0.0250387,0.00071866775,-0.024163006,-0.07314809,0.05669822,0.03380785,0.04281752,-0.022004766,-0.034057125,-0.019706989,-0.0047601177,0.012787035,0.015412088,0.044123657,0.04433753,-0.0051454837,-0.045259256,-0.04894544,0.035582207,0.0009907581,0.010332222,-0.0927485,-0.03758443,-0.05951048,0.059703514,0.032544103,-0.018860118,-0.02759277,0.02742005,-0.004618108,-0.02916378,0.036976,-0.028683767,-0.01107625,0.034818187,0.01824955,-0.03174593,0.010946893,0.035449717,0.013737862,-0.0028984353,-0.043327045,-0.0752606,0.043785747,-0.050084863,-0.11576185,-0.01501217,0.0041880365,0.028006038,0.033499457,-0.009214289,0.03837341,0.027216176,0.10512564,-0.028983958,-0.01680696,-0.029922849,-0.029856984,0.05689818,0.018268362,-0.0064229826,-0.051086,0.04878462,-0.0074409144,-0.08543104,-0.047482185,0.045823205,0.0064176847,0.01482074,-0.029379256,0.02207016,-0.06281652,-0.09390008,0.002995597,-0.033650253,-0.0031487558,0.04487789,-0.07324931,-3.473066e-33,-0.07254507,-0.048078954,0.045602996,-0.0036001639,-0.0068070246,-0.03282453,-0.04233457,-0.06482082,0.014735766,-0.06740458,-0.011439577,0.013852061,-0.030451005,0.14920026,0.01975435,0.043858413,-0.11063953,0.017861553,0.11258178,-0.048148304,0.01988606,0.0678961,0.03144242,-0.085559316,0.10484314,-0.011747783,-0.038868733,-0.028141305,0.064525746,-0.016985178,-0.014114537,-0.028822664,-0.063850984,-0.0019519543,0.036072906,-0.023850849,-0.051703256,-0.048514593,0.03513981,-0.06715104,-0.07718864,-0.014767288,-0.06945614,0.0466755,0.072616756,-0.027219767,-0.00025971283,0.030166838,-0.03390944,0.03472173,0.080860384,-0.11831026,0.037244644,-0.067703456,-0.01446468,-0.016944407,-0.011674771,0.07768483,-0.06235984,0.07036495,0.08066498,0.13244656,-0.026340548,-0.022610487,0.022254642,0.018456398,-0.09135802,-0.10612172,0.034852706,0.083963506,-0.009867112,0.021238482,0.03895276,0.04309161,0.04292843,0.023315845,-0.0654518,-0.050888676,0.0075410884,-0.007306501,-0.05571112,-0.05983403,0.02428597,-0.01329875,-0.09331945,-0.0041745524,0.003503173,-0.046585035,0.031677075,-0.04578771,0.08845317,0.063944474,-0.12347504,0.12282649,0.014518029,1.0196848e-33,0.08697883,-0.06638128,0.0655839,-0.02113397,-0.045066293,-0.009546889,0.025599623,-0.021101637,0.016894413,0.005402557,-0.0027353468,0.08506894,0.004545354,-0.008890237,0.050586008,-0.08224176,-0.02823361,-8.4665364e-05,-0.044544607,-0.025540449,0.0051826746,0.032531332,0.037752833,0.028424475,-0.0855051,-0.00802546,-0.0061047766,0.09920073,-0.009305797,0.022516314,-0.015641307,0.048117936,0.028905844,-0.073858015,-0.07109629,0.00052717945,0.00948393,0.04490291,0.009282934,-0.023907056,0.049143784,0.06866827,0.035783045,0.038153473,0.004879565,0.098028004,0.023941671,0.035512287,0.023673948,-0.03952332,0.0020149143,-0.026113829,-0.028161848,-0.009655428,0.06411231,0.08104712,-0.051565275,-0.016930345,0.076253675,-0.06774242,-0.07978628,-0.056223933,0.07012348,-0.037149023,0.007725558,-0.018152287,0.046873875,-0.038416903,-0.035337336,0.078660466,0.0813801,0.033927716,-0.03733024,-0.013335814,0.047971237,0.024037875,-0.05010182,-0.051400386,-0.075081855,0.00254589,-0.0570289,0.0525414,-0.040541418,0.013948401,0.114535496,0.00846468,-0.011102025,0.055222128,0.03319118,0.050095055,0.027852533,0.02621101,-0.016430525,0.074487954,-0.035432648,-2.8678842e-08,0.0034896184,-0.006739795,0.012929253,-0.06870189,-0.029175851,0.050011694,-0.032747455,0.04037352,0.10268866,0.080642365,7.302756e-06,0.09040899,-0.031014988,0.033583842,0.049077075,0.08433785,-0.049501408,-0.014926663,-0.004594903,-0.08667683,-0.023744881,-0.024817932,-0.018486597,0.108444504,0.040878076,-0.079760574,0.034996748,0.038922112,-0.024888555,-0.06272051,0.05065232,0.075922966,-0.023039132,-0.025118392,-0.04315536,0.026017446,-0.049253657,0.010444153,-0.012168895,0.069720976,0.04915296,-0.021568084,-0.08402501,0.0072946684,0.031918857,0.055992227,-0.055091593,0.06918027,-0.048211645,-0.0058393762,0.0438824,0.013653638,-0.025178887,-0.012382384,-0.08323753,-0.015033462,-0.08644935,-0.03940694,-0.017721035,-0.013879818,0.010035489,0.007433171,0.104196794,0.004966407 +7.5.2.4,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. An enzyme found in Gram-positive bacteria that exports teichoic acid.",384,1.0,-0.06911083,-0.06657033,-0.0436654,-0.049099427,-0.08190915,0.039566338,0.04399305,0.06923596,0.07656177,-0.040768057,0.049514472,-0.08466365,-0.0046222066,0.09228697,-0.021562308,-0.080423385,-0.027831808,0.016935537,0.049233723,-0.03960811,-0.0058077974,0.12217838,-0.03143428,0.025886938,-0.08171578,0.012923115,-0.003159922,-0.059610907,-0.016395845,-0.0026730963,-0.09244231,-0.013514903,-0.0013647039,0.009496931,0.005606647,0.124518625,-0.03368996,0.007536366,0.083098255,0.028877173,0.09639537,-0.015656915,0.07640627,0.043872274,-0.119707644,-0.017601538,0.061610993,0.052385602,-0.020997996,-0.010600238,-0.04925959,0.0013724181,-0.060826924,0.057360366,-0.02622821,0.08812531,0.019686097,-0.0030025858,-0.03549744,-0.013824293,-0.030943414,-0.00819504,0.096687205,0.07866106,0.037184786,-0.012933848,-0.056557033,0.018476082,0.024964979,-0.026028248,-0.079737924,-0.037581727,-0.029215964,0.059538826,0.024155205,-0.014146332,0.003740785,0.014032746,-0.015731452,-0.03501009,-0.0033965483,-0.06316146,-0.0493512,0.004942083,0.010947168,-0.03660843,-0.011030617,-0.009280402,0.0536228,0.025084523,-0.017659068,-0.039110526,0.053410076,-0.06008847,-0.115195274,-0.016296443,0.002833502,0.030297838,0.02589302,-0.047699623,0.050123975,0.07214381,0.039949358,-0.023072844,-0.020891482,-0.009399158,-0.01006682,0.031136636,-0.019978164,0.014365594,-0.009778635,0.016461466,0.031484503,-0.09382805,-0.016163953,0.048870966,-0.04673757,-0.020789828,-0.022751184,0.023949571,-0.06684296,-0.11728254,0.005253635,-0.039405316,-0.0018396933,0.026578996,-0.04202457,-1.3398308e-33,-0.058699597,-0.051771518,0.027948827,-0.01241937,-0.0126106115,-0.02284304,-0.026254032,-0.053182174,-0.0010275528,-0.099204645,-0.008916661,-0.0035076106,-0.020193815,0.104968585,0.018005686,-0.0013053025,-0.10253366,0.06084517,0.10318703,-0.019958397,0.017278818,0.074959904,0.021041986,-0.050852567,0.07316569,0.029777309,-0.038728278,-0.028023899,0.034926757,-0.0037868528,-0.0016179113,-0.024168644,-0.11601776,-0.025100017,0.067651495,-0.060112324,-0.0832845,0.012205634,0.055637334,-0.06498852,-0.08357707,-0.020336445,-0.06662312,0.08497611,0.06167077,-0.0536212,-0.0004945905,0.04319056,-0.009771539,0.00514578,0.07001609,-0.11792091,0.07652692,-0.058035336,-0.022215493,-0.050536565,-0.016901754,0.07250346,-0.06113888,0.077668026,0.06519758,0.15064809,-0.051996216,0.011718887,0.010356172,-0.0015267759,-0.08142033,-0.11833723,0.050786044,0.0851481,0.020709807,0.042632926,0.056420453,0.05605624,0.07388376,0.016978472,-0.06945465,-0.06000985,-0.018376743,0.0092882225,-0.043749966,-0.088129394,0.049222104,0.0056143603,-0.07221271,-0.028055338,0.014203786,-0.0102780815,0.022138404,-0.045633122,0.1241958,0.0583149,-0.07846971,0.12184413,0.023758162,-4.7328796e-34,0.0857842,-0.030360572,0.079016,-0.044395734,-0.049931757,-0.00938604,-0.009453934,-0.007034827,0.013248301,-0.032382954,0.016398681,0.049963463,-0.0032638945,-0.023302503,0.032286827,-0.087744795,0.011299548,0.018453414,-0.031112794,-0.050919756,0.022841811,-0.024478104,-0.017413924,0.046897408,-0.067060485,0.023977794,-0.051250007,0.080011085,-0.012746551,0.027523322,-0.01889421,0.045486122,0.0076238513,-0.037529483,-0.05767238,0.033230223,-0.0035965578,0.039465953,0.035735507,0.035139795,0.0709618,0.040343545,0.048717834,0.0135525465,-0.017014138,0.06587144,-0.0010209881,0.021978457,0.0022498667,-0.0012380085,0.03513303,-0.008016501,-0.03487754,-0.01621119,0.073974065,0.110246725,-0.063672446,-0.025781164,0.037256505,-0.08858527,-0.04272527,-0.066364534,0.062027037,-0.019641347,-0.005827732,-0.04479312,0.047815327,-0.03216377,-0.011231877,0.0756883,0.08647258,0.07435384,-0.014975441,-0.0012437048,0.07119337,0.010705838,-0.039938685,-0.04273392,-0.06102214,-0.013415616,-0.051119756,0.0613472,-0.0063278712,-0.012009564,0.1166834,0.013071295,-0.01885911,-0.02466125,0.01856503,0.045195974,0.02403095,-0.0013426347,-0.011095056,0.058499455,-0.0017189624,-3.2443843e-08,0.018846607,-0.047987122,0.020282151,-0.064883396,-0.010873619,0.036728047,-0.013154422,-0.0017157381,0.09941535,0.06367321,0.00935643,0.067464,-0.001427646,0.047507033,0.07662956,0.060911648,-0.056206215,-0.021469213,-0.031138262,-0.09430641,-0.017181123,-0.05150459,-0.039762616,0.07432363,0.05099606,-0.020139743,5.429142e-05,0.01012991,-0.029363029,-0.0664941,0.058226485,0.006151411,-0.030852228,1.6046382e-05,-0.013172456,0.034423802,-0.025317736,-0.022608768,-0.07588369,0.08644565,0.006407574,-0.005147473,-0.10983907,0.039523806,0.06882661,0.040993348,-0.059458792,0.08473108,-0.060915396,-0.010861313,0.0033216453,0.012343533,-0.008061495,-0.020290388,-0.07579383,-0.0567924,-0.06701468,-0.015997982,-0.031377293,0.0060007544,0.0576028,0.050680105,0.12407403,-0.034878097 +7.5.2.5,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzyme, characterized from the bacterium Escherichia coli, functions as part of the lipopolysaccharide (LPS) export system, a seven protein system that translocates LPS from the inner- to the outer membrane. The ATPase activity in this system is implicated in releasing LPS from the inner membrane.",384,1.0,-0.055959824,-0.0822274,-0.042029638,-0.00631015,-0.06535612,0.04431464,0.03139473,0.056390733,0.059877377,-0.021096509,0.016756058,-0.019211581,-0.024563527,0.056207996,-0.03056214,-0.07922146,-0.059871044,0.01849121,0.040618602,0.01633845,0.066833235,0.05013054,-0.058295835,0.0056181904,-0.04158585,0.026701078,0.0008775006,-0.07324751,-0.048321612,-0.021072935,-0.10483475,-0.050221186,0.001976803,-0.019545406,0.07774622,0.10979097,-0.0049325633,0.003296789,0.11282915,-0.012846155,0.09738132,-0.033560727,0.052214377,0.042952467,-0.09793874,0.008827675,0.010450482,0.06477426,0.06485263,-0.014871729,-0.02926132,-0.038428895,-0.038640697,0.051229164,-0.015974162,0.0385653,2.7504373e-05,0.020217953,-0.044020988,-0.00054722396,-0.053262237,0.014693003,0.059350066,0.10070621,0.00549388,-0.04483259,-0.01974285,0.0554342,0.001019008,-0.04733901,-0.10225717,-0.0032440952,-0.06680676,0.031066585,0.045283027,-0.0289901,-0.020329604,0.007769888,-0.017769216,-0.023044452,0.08634557,-0.036452457,-0.035973985,0.057202384,0.017314713,-0.018739713,-0.0020241078,-0.04150637,0.05443614,-0.0011965538,-0.023952512,-0.08312244,0.057824824,-0.01817681,-0.14611223,-0.017528765,0.013591705,0.016993886,0.038558446,-0.03712881,0.05103832,0.04341859,0.05425439,-0.053271994,-0.003182847,-0.0020144312,0.010447742,0.009500713,-0.030443342,-0.028824782,-0.008618803,0.019780174,0.06848227,-0.06533973,0.009219654,0.034950875,-0.011818895,-0.031509407,-0.03222575,-0.012943266,-0.10473086,-0.09608737,0.054983854,-0.002091736,-0.06585556,0.057347897,-0.027918652,-6.5766696e-34,-0.10335294,-0.089190155,0.031724334,-0.023272123,0.01219981,-0.07136614,-0.018501652,-0.07227916,-0.039836884,-0.049889203,-0.014653372,-0.10241753,-0.002485552,0.08473962,0.01682037,0.02069927,-0.062188223,0.07238479,0.10584192,0.01431528,0.006820464,0.050234072,0.05910632,-0.010964652,0.11610352,0.04883266,-0.06440467,-0.044832997,0.02303078,-0.002508367,-0.024534877,-0.012003666,-0.10538982,-0.020640925,0.023337,-0.02695647,-0.01484671,-0.023092218,0.050429378,-0.053020313,-0.08934531,-0.030402385,-0.09438602,0.053792246,0.02886692,-0.012605422,-0.08872889,0.029089672,0.016480988,-0.0030687193,0.053407796,-0.11165922,0.068725616,-0.007252061,-0.0016849824,-0.0530235,0.0039067566,0.028336413,0.0022921502,0.063705586,0.049100343,0.13480121,-0.0153129725,-0.037450433,0.06322985,0.026988938,-0.06220749,-0.103477,0.0099404855,0.08320574,-0.0242091,0.0035599233,0.026043504,0.06509948,0.11082098,0.02164494,-0.050897893,-0.013186869,0.019888947,0.04567998,0.050358847,-0.017515624,0.04181591,-0.0069470885,-0.032424387,-0.0467779,-0.030127132,-0.031107323,-0.012702157,0.0075789737,0.112812184,0.046104245,-0.054214627,0.14665203,-0.027947908,-1.8385848e-33,0.081555106,-0.02084965,0.10583159,-0.109378844,-0.06476713,0.027179774,0.0012316891,0.0413426,0.040824033,0.04387286,0.01012005,0.019438606,-0.027705234,0.024914645,0.02125301,-0.06960908,-0.024491033,0.013892759,-0.03804096,-0.03790684,0.010420009,0.033778574,0.041632168,0.114714354,-0.022500508,-0.02098391,-0.079898275,0.111799784,-0.015942562,0.019844595,-0.012369487,0.025247075,-0.016667413,-0.027212825,-0.086271904,0.034682028,-0.05249728,0.0709993,0.024807828,0.027808446,0.03724775,0.056106932,0.032209404,-0.04679541,-0.039117813,0.011399109,0.010322654,-0.004535666,0.0095962165,-0.024499105,-0.0023912855,-0.016411286,-0.0025032447,0.029678917,0.08332091,0.092410035,-0.030631356,0.040667307,0.021118736,-0.10107188,-0.06681428,-0.05306264,0.030840227,-0.02996002,0.05095245,0.021413691,0.02810408,-0.051572174,-0.048879523,-0.006000782,0.0462973,0.04375859,0.00030901676,0.050615404,0.071512334,0.051361606,-0.0813716,-0.07232666,-0.06319497,-0.0047566327,-0.051786568,0.012225126,-0.011199772,-0.042807568,0.08021485,-0.043346472,0.021017017,-0.028379535,0.041761715,0.051007308,0.07425027,-0.0311632,0.009459337,0.014033613,0.028222676,-3.8539756e-08,-0.031273313,-0.019399114,0.042639993,-0.086061254,-0.06172586,0.03754467,-0.012180178,0.00855906,0.06792561,-0.0012010834,0.020296885,0.08200345,0.04015635,0.045054793,0.04355584,0.01499457,-0.03275317,0.018361144,0.0023052548,-0.06428613,0.00031501875,-0.07582173,-0.04121123,0.066994876,0.053853724,-0.080358446,0.021806922,0.03263597,-0.050862476,-0.07832312,0.023163157,0.029541539,-0.027532974,0.03275515,-0.019849934,0.01600698,-0.037864167,-0.042740446,-0.05681135,0.10676602,-0.017089225,-0.029964458,-0.05818092,0.004975811,0.008793355,0.06937514,-0.010151735,0.078205466,-0.03215982,-0.018183645,0.06427712,-0.019324064,-0.019282402,-0.04872675,-0.046130657,-0.0582902,-0.10459578,0.026141107,0.00044337194,-0.007991718,-0.0008877887,0.04709075,0.16798805,-0.011052732 +7.5.2.6,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway. Not to be confused with EC 7.5.2.5, ABC-type lipopolysaccharide transporter (LptB), which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process.",384,0.99999994,-0.08074523,-0.084466614,-0.03708076,-0.031968057,-0.06596381,0.043549087,-0.0010757284,0.08346637,0.07260655,-0.045443747,0.018650513,-0.02732477,-0.029272426,0.0138557,-0.026237413,-0.039842945,-0.090017155,-0.013215727,0.035238683,0.010849908,0.061181787,0.05218868,-0.01749983,-0.014501565,-0.039077654,0.042259265,0.009948297,-0.028343404,-0.028018165,-0.035848733,-0.08383058,-0.039285727,-0.01021891,-0.0092135,0.045577597,0.08679329,-0.003306837,-0.032243006,0.12787695,0.005674706,0.10106823,-0.04803424,0.019203292,0.05092209,-0.07950542,-0.025220174,0.022032188,-0.00082458154,0.0003114096,-0.011720488,-0.03500251,-0.06920911,-0.047593094,0.042133715,-0.0006123214,0.03784739,0.032872804,0.035611894,0.013430644,-0.035533123,0.016612452,0.0369915,0.05524035,0.09779468,-0.017851362,-0.089029185,0.007080549,-0.010509053,-0.006924147,-0.040330853,-0.08721575,-0.05511234,-0.07272762,0.06260133,0.033669256,-0.0021383783,-0.00086903694,-0.0003114243,-0.025888007,-0.006587474,0.064627,-0.01936925,-0.0496813,0.088882886,0.017678848,-0.05047277,0.0015600163,-0.050985806,0.04539205,0.030456392,0.0026859182,-0.08284201,0.009680365,0.0048835683,-0.14310528,-0.010669193,-0.012238264,-0.011792429,0.06728744,-0.038199015,0.013753317,0.04403136,0.007909922,-0.007815018,-0.021183865,-0.01875678,0.03149685,0.007482695,-0.028246086,-0.02775761,0.0052277613,-0.028783213,0.06949773,-0.040720724,-0.021980949,0.06475297,-0.018438052,-0.019963492,0.011289617,-0.038592666,-0.08306931,-0.09424694,0.034591462,-0.0041574407,-0.053503327,0.07251756,-0.086448334,7.752146e-34,-0.042364724,-0.095603704,0.06959354,-0.0076530445,0.021724556,-0.041521136,-0.03402411,-0.07166121,-0.03997719,-0.043522425,0.014437899,-0.13609381,-0.0020956153,0.07653861,-0.03715109,0.012360703,-0.12967153,0.051902957,0.065382525,-0.0015995147,0.029488187,0.07819106,0.022504171,-0.02913652,0.0912104,0.01906081,-0.06085696,-0.014244104,0.046614137,0.009100151,-0.04577401,0.00040350523,-0.12483417,-0.003629965,0.056696024,-0.011428629,0.028020319,-0.0319542,0.036908183,0.0014895104,-0.08715728,-0.014836337,-0.06518767,0.019851651,0.0690367,0.008813786,-0.08512958,0.074791655,0.023033334,0.012580706,0.034749266,-0.09219192,0.061594684,0.02057332,0.0067525455,-0.009089789,-0.023171522,0.04111014,-0.0028156952,0.084307864,0.077793695,0.110367425,0.002693255,-0.023247194,0.065410025,0.048763197,-0.06721262,-0.09344464,0.0057243267,0.06171326,-0.0031733473,-0.012323152,0.043539584,0.05790962,0.0834134,0.005344415,-0.0745997,0.014395512,0.02064683,0.0070274966,0.022755489,-0.0043518594,0.04796402,-0.030609202,-0.033782545,-0.04569367,-0.012698489,-0.033284705,-0.023099585,0.010964136,0.074196674,0.041194957,-0.048443295,0.13648713,-0.041513555,-3.182781e-33,0.073612384,-0.026887832,0.13823415,-0.10259543,-0.04714698,0.012240265,0.0086276615,0.05057157,0.06775807,0.04167693,0.023701625,0.0060998225,-0.0011994402,0.007982478,0.0303002,-0.040926035,-0.06480043,0.009787062,-0.07334857,-0.0067525874,0.0059281625,0.034194544,-0.0016768618,0.110254146,-0.02362573,0.00025021657,-0.061471816,0.117936306,-0.035744138,0.005324039,-0.043036513,0.037831243,-0.05364448,-0.057467062,-0.10743141,0.06666181,-0.04817803,0.0803708,0.008670056,0.021340108,0.021129698,0.04933368,0.028196428,-0.029680712,-0.01793404,0.037612263,-0.008572712,0.0030333255,0.010350797,-0.034272354,-0.034222823,0.003739673,0.06250714,0.07661471,0.056360584,0.11487795,0.004717533,0.026713217,0.06624447,-0.10102941,-0.03717369,-0.020216674,0.07078917,-0.009638656,0.049580146,-0.01563444,0.0097022345,-0.04616219,-0.015666647,-0.027501175,0.037128307,0.052612193,-0.0037461235,0.024009557,0.07313776,0.04965362,-0.06213846,-0.09162927,-0.06578903,0.029379297,-0.017187687,0.033056542,-0.009478576,-0.05063444,0.040352046,0.003280274,0.013673899,0.00067040185,0.0059405454,0.058821715,0.011015686,-0.016103154,-0.014387041,0.030322157,0.05652192,-4.590151e-08,-0.031687815,-0.067170456,0.024965622,-0.084965,-0.047168545,-2.2754673e-06,-0.019312248,0.026150597,0.08871762,0.009435173,0.0052510705,0.11552452,0.04155899,0.048354525,0.015551354,0.04729195,-0.05177475,-0.018285232,0.00075558125,-0.038051054,-0.05028001,-0.0928168,-0.03704775,0.050259557,0.05693946,-0.07894411,-0.001260094,0.06778052,-0.056907356,-0.048391137,0.0046778563,0.040428042,-0.010395689,-0.004414365,-0.024044137,0.043701928,-0.05487702,-0.063522585,-0.06675932,0.085761726,0.011748155,-0.072498806,-0.035647318,0.0024372751,0.047548946,0.041624717,-0.01927952,0.10755636,-0.062567875,-0.02100314,0.04175444,-0.047326304,-0.020305887,-0.04647673,-0.05502135,-0.031881195,-0.10725997,0.054485973,0.014985303,0.03558083,-0.009473178,0.04157348,0.1707002,-0.020157885 +7.6.2.4,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome.",384,1.0,-0.09507969,-0.03352844,-0.035442386,0.00219204,-0.088809,0.008156874,0.049505863,0.06587493,0.06890201,-0.06985205,0.04919365,-0.06875932,-0.04006181,0.065809846,-0.033026744,-0.057190858,-0.046533242,-0.0037847718,0.035879772,-0.049605154,-0.008346675,0.117720306,-0.032599386,-0.003428249,-0.07066416,-0.037935738,-0.023691252,-0.0349209,-0.009625008,-0.007557096,-0.07129679,-0.0380941,-0.024471618,0.037257478,-0.008536773,0.105634585,0.004391205,-0.022017056,0.03858077,0.032108963,0.10210144,-0.045182917,0.023396965,0.08671353,-0.14443916,-0.013797946,0.025473515,0.008009843,-0.016214808,-0.0002351378,-0.04995428,-0.05095277,-0.061494805,0.044621117,-0.022135567,0.073022775,-0.013757161,-0.025845995,-0.05123901,-0.029090129,-0.0469699,-0.01108384,0.053306207,0.09710687,0.0404523,-0.037723973,-0.025717374,0.031641074,0.005509387,-0.045297604,-0.054091413,-0.09789449,-0.061632987,0.04539763,0.05658595,-0.011979029,-0.036939297,-0.031505752,0.013839886,-0.008819313,-0.0020340828,-0.0017850479,0.020983906,-0.0111431,0.04577679,-0.033823524,0.001097292,0.0019488271,-0.03345843,0.010266026,-0.02603322,-0.059112478,0.021477086,-0.0017633119,-0.085338905,0.03462186,0.037324592,-0.01436113,-0.0032055085,-0.010501883,0.056561716,0.09528117,0.04510254,0.0123483,0.0007801824,0.0117015615,-0.015891671,0.030810587,-0.029607888,0.014313616,-0.026534181,0.01684493,0.056005213,-0.06212012,0.008965175,0.040790737,-0.040519226,0.018415228,0.014223675,0.030786254,-0.087507986,-0.061408527,-0.012036862,-0.015396715,0.039656356,4.62163e-05,-0.073753886,-9.1517865e-34,-0.08098258,-0.038278826,0.006104997,0.03135807,0.018466434,-0.01981233,-0.031680293,-0.031951267,-0.005474144,-0.07718489,0.03468529,-0.014053865,-0.017560795,0.121277615,-0.019132506,-0.045888655,-0.05687783,0.07396459,0.114107,-0.0385728,0.02330891,0.05178205,0.025489071,-0.07411455,0.06073927,0.060111165,-0.07448679,0.0007064139,0.050368436,0.013260497,0.00012516294,-0.029698933,-0.098539166,-0.029779334,-0.0029414557,-0.03772412,-0.036511473,-0.022937901,-0.0063646175,-0.02562214,-0.07205052,-0.049183007,-0.08627249,0.04326752,0.0409564,-0.040829714,-0.04515932,0.05482655,-0.016802605,0.024247827,0.057787973,-0.12725483,0.06352003,-0.04533915,-0.02379879,-0.008441057,-0.042872358,0.027724221,-0.069706894,0.039667673,0.06791119,0.15735956,-0.04691627,0.05768723,0.05413856,-0.009645487,-0.11531485,-0.11868157,-0.0040440187,0.13561255,0.016975176,0.02411483,0.057658087,0.039226316,0.058488276,-0.004607247,-0.039972637,-0.02502062,-0.064620376,0.020384176,-0.032138422,-0.053199664,0.08315127,-0.020723203,-0.050896727,-0.041821353,0.011206972,-0.006668858,0.02544479,-0.046309542,0.1331493,0.060836084,-0.05587973,0.089857735,0.023569062,-9.521328e-34,0.08881417,-0.022873912,0.11235515,-0.09920222,-0.028418971,0.011345512,0.052552287,0.023207841,0.026914017,-0.038395785,0.016781852,0.064290226,-0.008292328,-0.06456176,0.042239156,-0.0406949,-0.0066459463,0.009001697,-0.004627575,0.0022631,-0.017316299,0.012056585,-0.022536129,0.09791764,-0.045146868,-0.02310156,-0.030134553,0.057819214,-0.020155612,0.0006582231,-0.003565763,0.03764121,0.01538162,-0.06310258,-0.051391993,0.030730743,-0.03758746,0.104017496,-0.049528006,0.021349054,0.047258887,0.040450107,0.0058889263,-0.01023065,0.012690678,0.058549844,-0.020810947,-0.025005009,0.02254624,-0.036651332,0.023051208,0.008821697,-0.003909077,0.0008580267,0.082853355,0.13192035,-0.03504574,-0.04010144,0.07690132,-0.11379808,-0.047875855,-0.04710034,0.04129862,-0.035181616,0.033514943,-0.03505515,0.008764829,-0.09119866,-0.03592004,0.085458286,0.11824187,0.09349067,-0.04168084,0.011333493,0.05253761,0.032642595,-0.028572012,-0.039565857,-0.09912101,0.0009645451,-0.043526713,0.03930312,0.0063270098,-0.007895218,0.03461328,-0.02750341,-0.012250704,0.010109502,0.019922819,-0.0010037565,0.041842476,0.002219834,-0.025657052,0.035864964,-0.017758492,-3.526399e-08,-0.0062151165,-0.041121695,0.0097588375,-0.07162746,-0.027291637,0.054135423,-0.0072839893,-0.024762124,0.075957134,0.07562396,-0.030752644,0.12507321,0.050228074,0.07230464,0.06650835,0.036347624,-0.018764786,0.021284474,0.007800159,-0.054023687,-0.050969,-0.02000368,-0.0047678733,0.07905961,0.037211947,-0.02987608,0.036814302,0.083882764,-0.013074437,-0.0557077,0.042750873,0.032704536,0.014373524,0.025346048,-0.015955674,0.028964387,0.010175905,-0.04265881,-0.099132836,0.0971455,0.046139475,-0.03154814,-0.041889712,0.008946678,0.06651633,0.0049787317,-0.033262976,0.053521663,-0.02098635,-0.0114861615,0.04657758,0.027261296,-0.056566745,-0.016219007,-0.049899656,-0.05092201,-0.080435045,-0.038085088,-0.048636995,0.00073147187,0.07270087,0.055715807,0.15574057,-0.055953518 +7.6.2.5,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzyme has been described from Gram-negative bacteria and green plants.",384,1.0,-0.093375914,-0.03733935,-0.015268241,-0.043312315,-0.08845141,0.024587493,0.054573998,0.058251724,0.07460383,-0.054315362,0.05108039,-0.053670127,-0.005409247,0.09060735,-0.019951144,-0.039743666,-0.044928513,0.03513456,0.033917647,-0.029482193,0.015912991,0.110791676,-0.05150729,0.019101823,-0.06497741,-0.0062765535,-0.024890192,-0.06081004,-0.028227007,-0.030202862,-0.10955572,-0.011866519,0.0045423745,0.023766201,-0.009912679,0.11518867,-0.009370742,-0.022083921,0.0842075,0.03443393,0.12115024,0.00022301733,0.069647945,0.05850722,-0.14788342,0.0038079822,0.039703492,0.0305706,0.0028297424,-0.03360941,-0.02615215,-0.0122540975,-0.053038996,0.035358813,-0.020858452,0.06592406,-0.004055879,0.024597852,-0.035759576,-0.031866573,-0.017278051,-0.0050787493,0.07932635,0.08144393,0.033591848,-0.021986851,-0.069821395,0.020458443,0.03729705,-0.034524053,-0.088663675,-0.072910786,-0.039395116,0.046124894,0.024661126,0.012036102,-0.025636066,0.062217694,-0.022921747,-0.042062655,0.035143252,-0.038267948,-0.029893905,0.015143541,0.011055381,-0.0043411,0.0047735116,0.018228946,0.020128347,0.007041622,-0.017258976,-0.052700974,0.04064088,-0.039981548,-0.11064319,0.011224954,0.011886944,0.0045482987,0.001099447,-0.0233165,0.071838394,0.06468151,0.055160202,-0.033614293,-0.0030641127,-0.015053518,-0.035925,0.0020759953,-0.02604042,0.009854281,-0.025779245,0.033547208,0.014139764,-0.08181485,-0.028166125,0.04828091,-0.03873636,-0.004223715,-0.020977385,-0.0010265423,-0.07331045,-0.12373563,-0.011777662,-0.038959984,-0.022602275,0.033351343,-0.07008508,-1.261445e-33,-0.094390005,-0.05872386,0.053098723,-0.027508885,0.00619545,-0.063786745,-0.025827782,-0.047303293,-0.010073878,-0.11342766,0.011669841,-0.020146674,-0.008396622,0.08518869,-0.0006555734,-0.017065872,-0.08927419,0.0507984,0.10012839,-0.03167555,0.043644506,0.054623194,0.0014119698,-0.043155096,0.09233551,-0.008826383,-0.03968887,-0.03621045,0.06426026,-0.026402356,0.00591185,-0.0411627,-0.081918515,-0.0007958535,0.03487819,-0.07894934,-0.059343036,-0.015185189,0.03539304,-0.061001487,-0.097420014,-0.032197345,-0.06689584,0.07813578,0.055284474,-0.040533867,-0.025301484,0.046195295,-0.0017742144,0.034674853,0.05343986,-0.123745434,0.076585956,-0.055390786,0.0069570052,-0.03946693,-0.0082439715,0.06757324,-0.05542423,0.05606882,0.069935046,0.14502196,-0.050682057,-0.016526096,0.035382748,0.0360424,-0.115650445,-0.1265447,0.055399075,0.124108784,0.011320462,0.01863294,0.020394608,0.05477454,0.08127651,0.016005578,-0.060136538,-0.045041613,-0.043924544,0.048565138,-0.023717104,-0.058104273,0.043041293,0.008847546,-0.08718275,-0.031533968,0.017317988,-0.015889222,0.018673245,-0.03876673,0.13843441,0.06314867,-0.07673617,0.118799254,0.030561384,-6.441555e-34,0.09380142,-0.024012452,0.09167676,-0.029565867,-0.04250141,-0.002029066,0.012040344,-0.014577748,0.028312445,-0.00737267,0.001715447,0.08220999,-0.011288841,0.007437698,0.036920227,-0.075089425,-0.00621618,0.020576095,-0.016542986,-0.007945343,-0.014265957,0.026230976,-0.003062557,0.049964007,-0.07321303,-0.018161315,-0.03483436,0.09363573,-0.030269347,-0.0015682383,0.0009305407,0.05586187,0.012305131,-0.027779909,-0.06673689,-0.003714652,-0.019687958,0.032909494,0.0028707557,0.015594861,0.041083567,0.049731214,0.04521653,0.018605778,-0.0056015807,0.052941974,-0.019791674,0.048535176,0.0076166373,-0.012807557,-0.0041543115,0.025964148,-0.023454988,0.015651204,0.077476956,0.1024277,-0.047944706,-0.0027217888,0.05739745,-0.07056032,-0.051369663,-0.07665656,0.06793247,-0.023210064,-0.0029847687,-0.02232654,0.04568347,-0.028947726,-0.04409315,0.06945429,0.10002212,0.081821434,-0.027909104,0.018808817,0.04902617,0.021216363,-0.007886064,-0.04014043,-0.08688089,-0.011083186,-0.041982967,0.062121324,-0.029521195,-0.020865584,0.09672115,0.014113146,-0.028726136,2.7988459e-05,0.020027654,0.05551243,0.04766137,-0.020583805,-0.0016915712,0.061746724,0.0044330712,-3.464057e-08,0.00041783063,-0.037762355,0.018116446,-0.07813104,-0.011886254,0.021987012,-0.017714867,-0.0006178443,0.09734688,0.06880419,-3.0635354e-07,0.06506265,-0.01375462,0.04359611,0.08613377,0.04777928,-0.033723354,0.02485069,-0.015494872,-0.052529927,-0.013399791,-0.05019405,-0.071371436,0.088975504,0.08055684,-0.030594697,0.030303823,0.035511393,-0.023404673,-0.0552729,0.07019563,0.03364332,-0.011181863,-0.012577866,-0.041099284,0.031426825,-0.03676248,0.0024710065,-0.07821876,0.07730265,0.035549294,-0.052849967,-0.08422373,0.018416429,0.04534252,0.0467377,-0.04538428,0.05449746,-0.044550437,-0.0032066773,0.041080747,0.010523542,-0.0017511324,-0.053664252,-0.078937605,-0.048713554,-0.06363801,-0.01987177,-0.028395174,0.010425095,0.03561132,0.03238491,0.14324309,-0.010901722 +7.6.2.6,"An ATP-binding cassette (ABC) type transporter found in insects that transports guanine and other purines into pigment granules in the eye, where they are converted to pteridine pigments. The transporter is a hererodimer composed of two different peptides, each containing one membrane-spanning and one cytoplasmic ATP-binding domain. In Drosophila, this transporter is encoded by the white and brown genes.",384,1.0,-0.070510134,-0.05917607,-0.016165063,-0.028697427,-0.041175142,0.061590727,0.14572115,-0.0029044333,0.01773763,-0.0024457779,0.07091519,-0.0910181,-0.067089334,0.08851361,-0.055512533,0.04990183,-0.053920705,0.0055404967,0.02758079,-0.05831824,-0.00048691852,0.09204931,-0.031689744,-0.010915629,-0.09685847,0.04492854,-0.008660953,-0.0939332,0.033975933,-0.080933884,-0.13521141,-0.030164035,-0.028725984,0.046318628,-0.012503368,0.05868277,-0.051814064,-0.017138876,0.053195976,0.037307948,0.14533745,0.02124739,-0.024604594,0.077200525,-0.107663475,0.011931731,0.079720974,0.046564635,0.010039767,-0.061035257,-0.04125239,-0.04592084,-0.05583176,0.01735786,-0.029746203,0.071611516,-0.022002092,-0.03798044,0.013248642,-0.02938606,-0.00023232188,0.0037006116,0.084738806,0.00024811554,0.048680745,-0.032777216,-0.020275444,0.005877136,0.058348086,-0.108459964,-0.06874555,-0.05332143,-0.042822935,0.040834356,-0.031088378,0.03553465,0.011377576,0.0099561,-0.041228015,-0.02402885,-0.010688597,-0.028146973,0.0027832496,0.06926499,0.102658875,0.02135825,-0.02583625,0.015213869,-0.07555371,0.036697198,-0.0076798075,-0.057325512,0.009949898,-0.025686061,-0.10033038,-0.015879227,0.02698474,-0.020559782,0.046269543,0.0098137455,0.00412128,0.010383871,0.04090011,-0.033060055,-0.06254617,-0.070478655,0.040660683,-0.0027113075,-0.01621778,0.022222957,-0.038294926,0.03466454,0.01276506,0.015471823,-0.03839718,-0.018696353,-0.091706425,0.015913595,0.11139157,0.06450374,0.0047689043,-0.040886138,-0.018735042,-0.00076187163,0.034945145,-0.072869435,-0.07648374,2.5508992e-34,-0.032586772,-0.021282732,0.028661592,0.007929085,-0.0068528615,0.003799017,-0.027222512,-0.03150593,-0.034551363,-0.10645863,-0.042978123,-0.016325869,-0.047844805,0.14625932,-0.033254355,-0.028875176,-0.05281152,0.058921766,0.14485973,-0.07289792,-0.0067462283,0.078766294,-0.03529518,-0.10184614,0.0602507,0.034203447,-0.107371725,-0.04608677,0.062777415,-0.01495934,0.02157133,0.005386563,-0.028238747,0.08129444,0.04338246,-0.021183297,-0.012133026,-0.04971967,-0.032252677,-0.0058533233,-0.091718376,-0.03170438,-0.057882626,0.07493023,0.06660419,-0.039194338,-0.1067755,0.036762208,-0.033076372,0.0037278235,0.031539645,-0.10191225,0.08420048,-0.07268858,-0.002688421,-0.048753437,0.004094034,-0.03967552,-0.061271574,0.027469683,0.05028878,0.12666237,-0.01331997,-0.018451791,0.12157387,0.015989142,-0.120004736,-0.071895264,-6.4766864e-05,0.04057171,0.030884463,0.021493997,0.074518986,0.004067732,0.034672532,0.04690689,-0.047786936,-0.000478789,-0.041711744,-0.00083477504,-0.05726495,-0.05659315,0.04495722,-0.024195153,-0.06648025,0.032565124,0.063157044,-0.019177709,0.05730141,-0.0012633282,0.098829396,0.010777716,-0.07331074,-0.015802762,0.021683926,-1.7779416e-33,0.013592015,-0.018554088,0.048739556,-0.005620722,-0.044377737,0.0145175485,0.007979094,-0.006762162,0.019263132,0.011000405,-0.009768949,0.09452042,0.0048639905,-0.076434836,0.0334287,-0.059715994,0.047403168,0.071928635,-0.02436286,-0.05896743,-0.062498897,0.04149577,0.013058769,0.0141153,-0.07997759,0.0118003115,0.033918776,0.07009073,-0.012883829,0.020372624,-0.0015156302,0.012224104,0.015966447,-0.038118128,-0.0321191,-0.015650183,-0.046799127,0.0219899,-0.023857757,0.023343474,0.021793801,-0.018468784,0.028454464,0.015675168,0.04472435,0.07338016,8.374861e-05,0.0134219965,0.004860272,-0.026645202,0.07500633,0.009041734,-0.014102081,-0.04343321,0.054095224,0.08605075,-0.007980573,-0.039962303,0.10046644,-0.07468627,-0.019003032,-0.07165407,-0.0020264396,-0.005514188,-0.00048456798,-0.058183696,0.022522982,0.016016515,-0.00012138587,0.05286638,0.12706755,0.039883703,0.030327098,0.035073712,0.042221967,0.032949526,0.03227591,0.012814869,-0.015364321,0.02670263,-0.06404923,0.046483655,-0.028656721,-0.00095483573,0.11921781,0.01485149,-0.016041677,0.028342273,0.016172837,-0.031451836,0.029557811,0.004105937,0.00078999205,0.056951612,-0.007928547,-3.5872848e-08,0.048786152,-0.021878786,0.028769867,-0.057792436,-0.020586632,0.018281655,-0.007981184,0.031726524,0.053309947,0.060875084,0.014301696,0.023134658,0.06095034,0.03251223,0.15469222,0.08465036,0.01574724,-0.01383721,-0.008760183,-0.07839899,-0.110666536,0.013133821,-0.05653746,0.05200758,-0.029790718,-0.010086335,0.023326546,0.07243814,-0.043145325,-0.017147861,0.06707591,0.06696236,0.009063986,-0.02444167,-0.023105212,0.018925946,-0.018062152,-0.043529183,-0.036541317,0.030645145,-0.031517774,-0.032587387,-0.05259682,0.021506777,0.024158549,-0.011247934,0.015915424,0.00450896,-0.07321619,0.01243327,0.015910184,0.043735363,-0.031588294,-0.014451582,-0.089020066,-0.08383198,-0.017221024,-0.06400176,-0.09278554,0.015385556,0.008331693,0.060941845,0.10094175,0.02751378 +7.6.2.7,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of taurine. In Escherichia coli the enzyme imports a range of sulfonates (including taurine) that can be used as a source of sulfur.",384,1.0,-0.053022545,-0.0781135,-0.008999547,-0.026830442,-0.07942944,0.035726678,0.07458843,0.08496763,0.08441825,-0.08959374,0.015724784,-0.002682211,-0.017497059,0.10876693,0.0041195876,-0.016910851,-0.022773245,0.033486437,0.06465455,-0.057708636,-0.0026548435,0.05107225,-0.061830066,0.024190407,-0.058291566,0.04304727,0.002977788,-0.037725188,-0.07915547,-0.0044348463,-0.07531063,-0.024383863,-0.0009376067,-0.008381885,-0.016683826,0.101826124,-0.0371519,-0.0030208656,0.065584324,-0.011760477,0.11570168,0.03668115,0.046294905,0.05075102,-0.09751475,-0.05037131,0.032107107,0.036919568,0.007332779,-0.05839708,-0.06471445,-0.015062381,-0.05956327,0.069454394,0.016943159,0.10516397,-0.029557746,-0.09540868,-0.0026396655,-0.08974306,-0.046161212,0.01523644,0.051263355,0.044505954,0.050753362,-0.059947316,0.006516733,0.04173876,0.041844603,0.023056198,-0.08344346,-0.01539023,-0.044564918,0.08139879,0.030597012,-0.022079768,-0.03886338,0.021214824,0.01338307,-0.06352018,0.004465725,-0.03600416,-0.03712467,0.03778007,0.08654885,-0.047211044,0.023410406,-0.025719408,0.04930121,0.006000284,-0.015047993,-0.048764642,0.006306173,-0.07019993,-0.07657277,-0.021057444,0.0016335766,0.056241114,-0.0010183682,-0.008779647,0.035943236,0.06184511,0.018744605,-0.016294535,0.00483433,-0.01692263,0.012374433,0.032869354,-0.022198992,0.020458378,-0.04868312,-0.024945904,0.0077634095,-0.054403324,0.031321414,0.09693062,0.013498212,-0.027647454,-0.073450916,0.014816808,-0.081234194,-0.088475354,0.011205482,-0.04670453,-0.01723685,0.035267264,-0.09375868,6.6396246e-34,-0.036223248,-0.013083637,0.05346187,-0.01351168,0.0074233613,-0.05631916,-0.04566289,-0.07689127,0.008694283,-0.06401347,-0.019423041,-0.020625064,-0.012944926,0.08984419,0.021326397,-0.018904593,-0.07189139,0.1049652,0.13557976,-0.021029579,0.0072427266,0.04185919,0.014296885,-0.065140925,0.068987735,0.011959195,-0.060512435,-0.01896215,0.0036586553,0.011991203,0.054937005,-0.02119778,-0.09327522,0.009576596,0.055379502,-0.06438507,-0.07348325,-0.04123656,0.05450011,-0.0330656,-0.0689409,-0.043276496,-0.017862182,0.09288393,0.009920718,-0.04160431,-0.024610307,0.022065384,-0.0270592,0.061450224,0.034300953,-0.13090737,0.08962646,-0.11096439,-0.037013426,-0.024417749,0.036474116,5.00207e-06,-0.033128243,0.07590395,0.031108333,0.1332761,-0.053405575,0.015400309,0.058958694,0.018050252,-0.07442864,-0.10450554,0.031656053,0.116274446,-0.031783003,0.0044178627,0.009418495,0.07230895,0.039151084,0.017938444,-0.082614705,-0.025827162,-0.010598134,0.010092235,-0.053866725,-0.10935787,0.0059101656,0.015046783,-0.05942489,-0.011139135,0.009824602,-0.041406386,0.040854335,-0.0043055415,0.1090851,0.049254756,-0.074276574,0.10381285,0.027509091,-1.6624888e-33,0.07258729,-0.039074853,0.058542717,-0.069511406,-0.07683975,0.051797673,0.015721649,0.015394278,0.043943916,-0.014702503,0.010458555,0.057841778,0.00049539027,-0.034820423,0.017079841,-0.04435495,0.03251401,0.002457672,-0.019570962,-0.04378746,0.03117591,-0.0016889516,-0.014111306,0.0592952,-0.022964584,0.0037158385,-0.0045000343,0.03727799,0.022535356,-0.0081071975,-0.021013005,0.031762745,0.028850049,-0.0937357,-0.057158936,0.0104086995,0.054708295,0.057723764,-0.015143808,-0.021639401,0.041695494,0.04650626,0.02996654,0.06478876,0.00244293,0.059106324,0.0253087,0.032710966,0.007820736,-0.028126521,0.044268683,-0.07472205,0.016474426,0.0006541334,0.038680974,0.06172875,-0.019100722,-0.03681339,0.043634854,-0.07776457,-0.04756486,-0.044942845,0.028614242,-0.050429877,0.0048465445,-0.05649476,-0.015419149,-0.10229545,-0.039570764,0.05457116,0.07047742,0.016229808,-0.005264392,0.023406634,0.025837656,0.028189622,-0.026259294,-0.011865538,-0.0357736,0.013510108,-0.037132006,0.06493297,-0.015790703,-0.0460339,0.10478246,-0.021311035,0.0061360477,0.047232725,-0.00180109,0.015173154,0.02369749,-0.0015092767,-0.0032870737,0.061620366,-0.06323543,-3.7067885e-08,-0.0040134443,-0.029038168,0.010172,-0.028314453,-0.008280125,0.058810923,0.0044338885,-0.010070593,0.090601474,0.056422982,-0.006956086,0.148274,0.036764264,0.02635206,0.03362497,0.07916363,-0.045261092,-0.013864877,-0.018174762,-0.08726176,-0.0011523559,-0.021563236,-0.043159533,0.078966185,0.12313568,-0.044201955,0.036521092,0.04470825,-0.05621734,-0.0769944,0.07489686,-0.007008575,-0.04657659,0.0047020037,-0.017052159,0.032127224,-0.026240673,-0.05335152,-0.019644538,0.058128648,0.026390132,0.011316844,-0.12141855,0.019185698,0.07890868,0.06801664,-0.073291846,0.028503185,-0.09700985,-0.0058774566,0.034651585,-0.025798501,0.018554496,-0.06540559,-0.09041096,-0.007985047,-0.0036029443,-0.061129052,-0.019296365,0.007568863,0.06331125,0.016494121,0.14339186,0.012181273 +7.6.2.8,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives.",384,1.0,-0.072788015,-0.047282804,-0.04126952,-0.06014583,-0.08950461,0.011657227,0.05871046,0.059533745,0.051007967,-0.060924724,0.032714486,-0.066084765,0.018839048,0.10945358,0.0055482285,-0.06841992,-0.03510434,0.013415898,0.014480229,-0.049528968,-0.02781397,0.10031866,-0.060929418,0.0371514,-0.06688952,0.005405036,0.007406111,-0.03625245,-0.021815326,0.010804885,-0.10517538,0.00065926835,0.022901822,0.03542028,-0.00680354,0.11916236,-0.00084513857,-0.014674494,0.09928135,0.024856666,0.10217275,0.030826926,0.08445617,0.062595345,-0.09311129,0.0008508008,0.045639176,0.03915961,-0.012633065,-0.013372472,-0.060736008,-0.025010284,-0.05019273,0.067909,-0.015296468,0.06401497,-0.02869504,-0.011999243,0.010162652,-0.055039484,-0.028382616,-0.02623796,0.10751901,0.1051397,0.045012586,-0.05715742,-0.019706786,0.01631027,0.019297985,0.00047863298,-0.041534066,-0.054963086,-0.06631905,0.03471831,0.030350236,-0.018401895,-0.03355587,0.020793589,-0.036933653,-0.027728166,-0.0033850018,-0.035039615,-0.00025567994,0.036461517,0.029330384,-0.044422176,-0.028078077,0.0008533471,0.025418108,0.028152334,-0.027801361,-0.0615787,0.059050325,-0.03932885,-0.13220413,-0.01846314,0.0022480176,0.03543672,0.0034591607,-0.027963785,0.019336909,0.06777676,0.038440615,0.029792486,0.028882934,-0.045233782,0.036868423,0.04824608,-0.02356188,0.017239377,-0.01862624,0.012059579,0.03149241,-0.086169615,-0.012026866,0.07571962,0.010993102,0.0067653977,-0.051232204,0.021193534,-0.05141886,-0.10861323,-0.0032565128,-0.06539507,-0.033187173,0.008986544,-0.0627468,3.7570804e-34,-0.0751247,-0.0631002,0.04317326,-0.021907706,-0.0039707767,-0.05244537,-0.04012345,-0.034161396,-0.007915019,-0.121418715,-0.009072302,0.029021902,0.0047560614,0.12370827,-0.02473936,-0.024007682,-0.094500475,0.04649417,0.12407914,-0.0051013096,0.060708836,0.037733223,0.018464329,-0.0037384524,0.08230234,0.014910652,-0.013096744,0.00019370984,0.0471497,-0.0014856524,0.006264394,-0.051190507,-0.09085637,-0.031071594,0.030992648,-0.0586161,-0.075245425,-0.011225473,0.023987053,-0.03282699,-0.08226001,-0.05452141,-0.09862604,0.07705391,0.04448028,-0.044377137,-0.03192659,0.055579606,-0.041782513,0.038274296,0.04801485,-0.1158883,0.06873223,-0.045428284,-0.031346515,-0.013679249,-0.006412146,0.027292842,-0.06647172,0.0735567,0.06401437,0.11920132,-0.030771233,0.053958952,0.02918769,0.031747688,-0.06428779,-0.13250521,0.04777891,0.08647852,-0.009084347,0.0035523656,0.030751051,0.074287035,0.036291387,0.0016124952,-0.07906744,-0.09752972,0.008568325,0.019994104,-0.032888994,-0.10157923,0.061798193,0.014194085,-0.08363611,-0.0294227,0.025124945,-0.035102114,0.0042308774,-0.068690516,0.094476014,0.073305316,-0.034961108,0.102690056,0.026820706,-1.7328065e-33,0.10443265,-0.045736454,0.103457436,-0.042908292,-0.04588442,0.014716749,0.031171888,-0.039919324,0.042779345,-0.020872358,0.00230641,0.03394237,-0.02132883,-0.007610564,0.0056465655,-0.056979224,-0.02072732,0.03514574,-0.033499904,-0.02886559,0.010004442,-0.011696345,0.0049265223,0.0054538627,-0.07330311,0.018021919,-0.0379792,0.06748797,-0.026879363,0.0521417,-0.049897615,0.03714966,0.016809082,-0.060669858,-0.061713275,0.069943845,0.022228183,0.03666204,-0.030103348,-0.028863234,0.024511697,0.056812726,0.024810867,0.034981195,0.012682781,0.10498228,0.009129001,0.0723638,-0.010648239,-0.014422259,0.018723492,0.010044815,-0.035645332,0.03394222,0.061757267,0.0906264,-0.030884057,-0.015938304,0.06329672,-0.11526831,-0.045322653,-0.08448434,0.04193044,-0.009907531,0.011757246,-0.020056695,0.0630413,-0.04961608,-0.026346406,0.07697124,0.076934524,0.028303681,0.010440013,0.014095334,0.031338844,0.047034524,-0.04506891,-0.061123874,-0.06492335,-0.006211622,-0.07046669,0.01963636,-0.0043090284,0.0051257056,0.08712865,-0.011783978,-0.0073038987,-0.0039084107,-0.0027387405,0.05429147,-0.0034263772,-0.013531316,0.0011818276,0.03245171,-0.011316898,-3.5430322e-08,0.03608915,-0.047653984,-0.004393758,-0.062252942,0.031829458,0.05878631,-0.06660298,-0.0045752437,0.11545514,0.055312965,0.017545125,0.07950676,0.0122226775,0.053653773,0.03470593,0.04891532,-0.031669453,0.01718079,-0.013356559,-0.064506315,-0.037013415,-0.020362707,-0.018503068,0.054236747,0.0944063,-0.030975869,-0.012666258,0.054420333,-0.029976835,-0.08432181,0.053472348,0.0206146,-0.0003490145,-0.012565226,-0.03687507,0.028277598,-0.03462046,-0.013838133,-0.07170421,0.09324979,-0.002320823,-0.03443865,-0.10741588,0.021140264,0.060895935,0.040865622,-0.047452435,0.07519261,-0.087509274,-0.012999869,0.058519006,-0.018558318,0.015174053,-0.010367876,-0.066630065,-0.021894865,-0.06396242,-0.05259532,-0.029751396,0.022648226,0.027445737,0.050465684,0.108529426,-0.04627482 +7.6.2.9,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of quaternary amine derivatives.",384,0.9999999,-0.072835125,-0.08006565,-0.03238241,-0.051365476,-0.097229905,0.00088671,0.07303321,0.06348875,0.059082408,-0.04437433,0.026534552,-0.052557625,0.0021132838,0.13763958,-0.00018167026,-0.035981618,-0.07007832,0.025949672,0.03326795,-0.029082434,0.010298921,0.1033021,-0.043960333,0.03163718,-0.062847115,0.027663577,0.011702317,-0.04746352,-0.038047455,-0.0009853047,-0.08883743,-0.0039506773,0.01954232,0.014465121,0.048449095,0.10984758,-0.010213449,0.0028688575,0.080819026,0.016652025,0.10143031,0.0042190556,0.08361369,0.039378177,-0.12573184,-0.008121911,0.05424299,0.040859696,-0.00087845104,-0.031396266,-0.03656516,-0.025502667,-0.03446282,0.058540743,0.005286937,0.057655398,-0.017036628,-0.013627295,-0.034220062,-0.04349713,-0.032971185,0.0072590597,0.08805216,0.0939289,0.035960976,-0.06708719,-0.047010172,-0.0012492634,-0.0030659186,0.0034548366,-0.06860812,-0.070075,-0.061836764,0.053605724,0.050134074,-0.05960939,-0.0024153402,0.036741074,-0.03809017,-0.031135634,0.0006463365,-0.04744642,-0.006197118,0.029391153,0.033192582,-0.015352162,-0.012850111,-0.008813846,0.026832687,0.012204306,-0.029192762,-0.07127509,0.041426454,-0.052132465,-0.10252989,-0.03422489,0.006486349,0.020133138,0.020451197,-0.0057421504,0.051946353,0.044115208,0.017444434,-0.0028474738,0.009974249,-0.024218105,0.017362079,0.016647419,-0.025454286,0.011446114,-0.019118913,0.013360933,0.045212016,-0.06550572,-0.021957766,0.048290733,-0.0070183575,-0.0049136463,-0.025867391,0.006092717,-0.08734995,-0.10924187,0.012497701,-0.035263356,-0.03649782,0.028413204,-0.06681087,7.7484115e-34,-0.0872544,-0.05999515,0.021674527,-0.031573173,-0.0010694071,-0.033181187,-0.015591077,-0.051548008,-0.0010471257,-0.11179933,-0.029696083,0.004215783,0.0139377145,0.11790398,-0.01585665,-0.025074985,-0.09931196,0.087966844,0.124755695,-0.022537887,0.047711134,0.04415287,0.015472813,-0.012571824,0.104095586,-0.004054043,-0.040162984,-0.0126371635,0.06645405,-0.010604221,0.018497763,-0.040602777,-0.10837584,-0.041234575,0.026310094,-0.059138093,-0.050842714,-0.012105795,0.029375594,-0.030026315,-0.09025877,-0.043285735,-0.077067964,0.072793595,0.036810666,-0.022228912,-0.009451925,0.05489114,-0.049584143,0.025467021,0.043266278,-0.12965585,0.067875974,-0.09219716,-0.03307272,-0.024108175,-0.005267079,0.030150803,-0.040644135,0.056582667,0.06128874,0.13059549,-0.039554466,0.010669807,0.040120684,0.030164171,-0.052252036,-0.1185837,0.051507685,0.1136581,-0.01748008,0.02520986,0.052885823,0.054270104,0.057500944,-0.004617183,-0.09788066,-0.06929103,0.020628035,0.04010351,-0.024328694,-0.08852181,0.056984782,0.012237303,-0.064751364,-0.05832358,0.019766176,-0.041834876,-0.00968687,-0.044251405,0.12995446,0.036006268,-0.06512163,0.108933695,0.037371997,-2.422548e-33,0.11097514,-0.043176655,0.09418215,-0.03357285,-0.048963856,-0.0005537589,0.0068803327,-0.012266779,0.030481784,-0.046553843,0.009211257,0.049631517,-0.010786442,-0.009218898,0.016520916,-0.08720745,-0.034915064,0.025063094,-0.028115021,-0.024381164,0.042572737,-0.011045508,-0.008575734,0.008281991,-0.0682801,-0.015750164,-0.059686154,0.08012837,-0.018045643,0.021675492,-0.04926648,0.032326773,0.0105980085,-0.0721888,-0.05411952,0.060352106,0.022738043,0.036895655,-0.03666759,-0.019012302,0.039051834,0.06857783,0.018571524,0.045127157,0.0013673643,0.09469887,-0.011094595,0.0501944,-0.005721261,-0.030077836,0.0054528583,-0.006957824,-0.00028657357,0.021589048,0.06130856,0.083221875,-0.042907346,-0.006571235,0.06552063,-0.07528946,-0.061467223,-0.086277515,0.06414127,-0.012616877,0.00624895,-0.025587114,0.025775645,-0.052920245,-0.025955142,0.060147416,0.08315048,0.014816571,0.010154329,0.027085746,0.031651955,0.015031088,-0.023131054,-0.05824388,-0.04739821,0.012182321,-0.045793924,0.032997545,-0.02125162,0.009037624,0.100477934,0.019308347,0.018012654,-0.005278241,-0.015400184,0.037253026,0.03894847,5.276249e-05,0.026186533,0.056241445,-0.036744796,-3.7832887e-08,0.02647013,-0.037700832,0.001006485,-0.07722771,0.030464191,0.035979237,-0.048045002,0.019099485,0.10261635,0.043490343,0.025201945,0.09005301,0.008292419,0.04582045,0.085660264,0.07051583,-0.046882372,-0.0068138884,-0.0058504078,-0.077741705,-0.034232102,-0.015722195,-0.045565348,0.0706248,0.09590701,-0.012153519,0.0033256537,0.04353226,-0.024116227,-0.063315,0.048971944,0.029766455,-0.01307682,0.009944075,-0.03707062,0.02245543,-0.061978936,-0.01492356,-0.08041311,0.081117354,0.02823644,-0.038818017,-0.09309317,0.010970026,0.06730844,0.052169446,-0.067974925,0.066198766,-0.07984338,-0.031718917,0.05515231,-0.012969811,0.004141728,-0.0065487027,-0.07019308,-0.029708162,-0.069235116,-0.03563249,-0.034642223,0.032355577,0.05004401,0.049552545,0.114934765,-0.015297389 +7.6.2.10,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of glycerol 3-phosphate and various glycerophosphodiesters.",384,1.0,-0.05879616,-0.081825815,-0.02812159,-0.035048537,-0.08419471,-0.012815845,0.066158384,0.06728057,0.031485636,-0.07446809,0.028262531,-0.027765183,0.0012307923,0.12095209,0.0016718052,-0.06323578,-0.04062554,0.024398321,0.024592824,-0.031431217,0.016249117,0.08330759,-0.04686707,0.014477155,-0.059029035,0.0060236277,-0.0052019577,-0.040756863,-0.018971061,-0.0008809127,-0.11026125,-0.011655938,0.017954685,0.02032885,0.03896009,0.110951245,-0.014527308,0.016545847,0.06515628,0.014946958,0.106683485,-0.0011152219,0.06850201,0.053933375,-0.12601621,0.0046941643,0.04832675,0.036936764,-0.0051312787,-0.021608032,-0.042594243,-0.029650087,-0.04824628,0.04640323,0.009599139,0.050976083,-0.029463423,-0.000633137,-0.018549358,-0.056265455,-0.029431164,0.0027791653,0.107323065,0.102716625,0.020993922,-0.08113514,-0.011681853,0.010360252,-0.00016281001,0.027009584,-0.06349847,-0.04883172,-0.055386633,0.050909076,0.04449988,-0.026688239,-0.039386317,0.042798415,-0.013138246,-0.050070476,0.020109827,-0.055570252,-0.015968096,0.04933922,0.010662192,-0.039842445,-0.01859116,-0.019417059,-0.0014605011,0.001094546,-0.015369236,-0.09395846,0.018873135,-0.04958114,-0.10849166,-0.035954118,0.0020840117,-0.011761941,0.021626694,-0.018991457,0.027550152,0.061897356,0.05306224,-0.0012591317,0.011628276,-0.007122854,-0.012512975,0.0032466685,-0.012083878,0.019394396,-0.018909134,0.029677926,0.05249936,-0.07782837,-0.022680774,0.06382461,-0.019013377,-0.000118841235,-0.03226888,0.023848629,-0.06259945,-0.11587943,0.018578643,-0.051721938,-0.036713716,0.048972357,-0.061123434,1.5532762e-33,-0.07367299,-0.0379963,0.027242841,-0.031486545,-0.00011007645,-0.051416926,-0.014247343,-0.07534005,-0.03146606,-0.084110074,-0.00083019334,0.00028893916,0.01064486,0.14960833,-0.008452595,0.0066481554,-0.09601213,0.08494438,0.11699387,-0.035649773,0.06790919,0.0145515185,0.022322712,-0.038017575,0.110164516,0.03346249,-0.03399408,-0.004438387,0.067815624,-0.012159079,0.030882137,-0.062312473,-0.08996357,-0.015489821,0.05390252,-0.060944926,-0.044062883,-0.044031985,0.05078549,-0.043524295,-0.09379459,-0.05507083,-0.0656116,0.068037264,0.057058662,-0.0052701836,-0.044663265,0.038099807,-0.030192712,0.032874387,0.054560084,-0.14886415,0.08139967,-0.066006936,-0.030579224,-0.00797108,0.005864495,0.033579487,-0.04964563,0.045880914,0.0446037,0.14344169,-0.041686997,0.006280303,0.053567596,0.050863247,-0.081971206,-0.12425173,0.029735837,0.092357,0.00074929616,0.01679164,0.043831438,0.04956004,0.011316771,0.005112399,-0.078463025,-0.054204762,-0.015333006,0.03543738,-0.03838728,-0.06823784,0.05412481,0.0075104455,-0.0632559,-0.03863245,0.00040952078,-0.07025767,0.010668712,-0.047180988,0.1301487,0.061469506,-0.058603957,0.107494324,-0.013533767,-2.9583508e-33,0.11721445,-0.0305555,0.12269915,-0.027011167,-0.039519195,0.003956488,0.017120164,0.0050624986,0.030552024,-0.032442197,-0.01763509,0.04205943,-0.009069108,-0.00901845,0.015897194,-0.06468614,-0.015833788,0.0356948,-0.035999697,-0.032256354,0.04431778,-0.013456313,-0.0042240643,0.03888109,-0.058263913,-0.020256639,-0.053564493,0.059763506,-0.055464838,0.008260075,-0.013046665,0.04494824,0.002826491,-0.07610506,-0.048561428,0.041978724,-0.0006596514,0.055050135,-0.025988698,-0.033861555,0.03552697,0.07262761,0.04129343,0.027119821,0.025953714,0.08345113,0.0037288703,0.047947925,-0.0042730626,-0.019482212,-0.016277999,-0.019855184,-0.008929155,0.03247074,0.0743877,0.09479293,-0.020244913,0.0039751153,0.04230806,-0.0878454,-0.063081145,-0.10134638,0.065535024,0.0023338378,0.027937042,0.017288579,0.038815115,-0.069278605,-0.008084216,0.07343618,0.06796975,0.008540179,-0.0063656727,0.03277184,0.047857028,0.05149422,-0.043474346,-0.044613987,-0.051566057,0.005340053,-0.036232658,0.038242083,-0.026223326,0.0024263107,0.104316466,-0.00976159,-0.0017266605,0.030721517,0.006649286,0.035213675,0.019663243,0.0010843741,0.00854717,0.015103652,-0.025235813,-3.8525638e-08,0.036539964,-0.036332566,0.007291226,-0.09592268,0.022824736,0.025814218,-0.024267774,0.019869937,0.08860958,0.03515266,0.008365116,0.06783986,0.015447818,-0.015654523,0.07499204,0.071144335,-0.047557585,0.0059323222,-0.019097202,-0.08263425,-0.03215574,-0.014685187,-0.05348176,0.10384672,0.10122219,-0.018376911,0.021509118,0.04324428,-0.046078444,-0.050908703,0.03377013,0.032122795,-0.038978234,0.019216081,-0.026744423,0.014880989,-0.06768908,-0.0027824615,-0.07642014,0.0866521,0.016873404,-0.008889858,-0.070075765,0.0066709057,0.04954917,0.05736331,-0.063589886,0.046498325,-0.07008862,-0.029788291,0.034407265,-0.015063925,-0.00775445,-0.024338232,-0.108083606,-0.026798332,-0.077700146,-0.018982356,-0.03929464,0.027797673,0.034932446,0.042011358,0.13109708,0.0005188334 +7.6.2.11,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports putrescine and spermidine. In Escherichia coli the enzyme imports spermidine preferentially. 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+4.1.1.114,"The enzyme, found in certain bacterial species, catalyses the last step in a pathway for the production of olefins.",384,0.99999994,-0.05405844,-0.042972557,-0.06621538,0.053839955,0.110183366,0.029149935,-0.07721533,0.056509145,0.051109847,0.011476923,0.029165505,-0.030706994,-0.08577121,-0.015330525,-0.049617544,0.013716198,-0.122990854,-0.025981873,-0.016193883,-0.025257096,0.09992413,0.02615077,0.0031052611,-0.0054595424,-0.02344516,0.016513867,0.049163498,-0.06791506,0.03834694,-0.06674372,0.0263292,0.006323091,0.05522181,-0.043948725,0.039728645,0.015034783,0.006078978,-0.12093637,0.031384252,0.012637263,0.045141783,-0.034149196,-0.008688315,-0.0568845,-0.00947466,-0.045439433,0.0063775945,0.031131988,0.048579745,-0.061122008,-0.064746164,-0.053739335,-0.06208052,0.005991083,0.053757638,0.04276126,-0.027409663,-0.082227156,-0.030882886,-0.005221076,0.06490137,-1.2832546e-05,-0.038320314,-0.017780203,0.007922,-0.043542974,0.06608534,-0.05794247,-0.0051761437,0.04352143,-0.08417621,-0.03294692,-0.073537655,0.10782538,0.050443992,-0.0062093437,0.054270707,-0.04662088,0.03843702,0.008546549,-0.011199897,0.0054804934,-0.025075935,0.09806408,0.021582708,0.0030868882,0.030601008,0.02743478,0.095408596,0.039021544,0.0034514284,-0.04581486,-0.03646788,-0.06571553,-0.02510652,0.04301086,0.0062894216,0.026453203,0.0790352,-0.03429626,-0.054861862,-0.0015534362,-0.03708324,-0.12820399,-0.10964851,0.025651695,0.022191497,0.093740635,0.038874228,0.010300926,0.047983903,-0.05135839,0.056351397,0.016597215,-0.09456731,0.064484574,-0.0020301035,-0.1219424,-0.065033816,0.039061476,-0.025888307,-0.004381805,0.059031047,0.120171346,-0.07659292,0.012998555,-0.083109,-3.970143e-33,0.03346497,-0.015368601,-0.009811962,-0.07721439,0.059973132,0.01757771,-0.043458167,-0.0016435655,-0.028747102,-0.03478237,-0.08852855,-0.034002595,-0.018767012,0.020140344,0.016809436,-0.090653904,0.046187043,0.06804001,-0.019088853,-0.010628203,0.013532024,0.03480161,0.032955144,-0.046649843,0.025964648,0.054127418,-0.008347597,-0.018481018,0.03962592,0.004713202,-0.0031471418,-0.088620946,-0.087778755,0.015025814,0.08624619,0.016005874,0.0069670486,-0.08614222,0.023651406,0.06407164,0.0049590617,0.051053885,0.027738327,0.029784549,0.020629749,0.004505157,-0.040949434,0.10010273,0.07043595,0.06769949,0.023081549,-0.03588954,0.058552627,-0.02860871,-0.04332729,0.05937691,-0.11576909,-0.032659072,0.003749068,-0.007503232,-0.058403414,0.05323044,-0.078247935,0.055775806,-0.02032333,0.035313796,-0.011158905,0.013774814,0.012024906,0.07653943,-0.062527336,-0.061485574,0.032669093,0.016344072,0.045414623,0.0059326175,-0.07178779,0.048254456,0.045465797,0.009562323,-0.0171988,-0.027100394,-0.039691705,-0.0065108,-0.041285295,0.016722193,-0.060552992,0.0044191666,-0.018679433,0.049574018,0.037175655,-0.06750691,-0.031003276,0.04779223,-0.037992217,5.0027106e-34,0.089813516,-0.10642614,0.01389302,-0.071646415,-0.05365028,0.04526443,-0.036726516,-0.0517042,0.042815134,-0.021741517,0.057093482,0.00656796,0.026244905,-0.07793921,-0.03428812,-0.021195447,0.047865894,0.08826838,-0.021108685,-0.037547078,-0.028949618,-0.004300721,-0.005084507,0.012913533,0.054634992,0.022666536,0.040170856,0.08820581,-0.044276737,0.03730711,0.01731438,-0.046604924,-0.037956588,-0.039126806,-0.016170297,0.101404056,0.04177618,-0.014630105,0.06620824,0.032756492,0.02674887,0.0034961947,0.035181705,0.0005791771,0.051249985,0.043441832,-0.096585825,0.08239424,-0.025076134,-0.09043538,0.06720265,-0.011691494,0.06303933,-0.02282994,-0.040712498,0.039440505,0.02096472,0.018167146,-0.0073412512,-0.05716673,0.0013731974,-0.04583115,0.0813293,0.016120726,0.0012556639,0.043345705,-0.036719687,0.0094901705,0.008267997,-0.057023276,0.013361284,0.018540842,-0.035585128,0.046560306,-0.05176643,0.037089877,-0.061967667,-0.11758292,0.011332154,-0.014702104,-0.02225347,-0.029017093,0.01523125,-0.1120872,-0.03674549,-0.03529799,0.051455695,0.059792813,0.035624094,0.057628695,-0.119833834,-0.029832713,-0.04168185,0.052167177,0.072213605,-2.3782182e-08,-0.024802536,-0.011967379,0.025674319,0.0042861216,-0.0064191585,0.026288884,0.021457318,0.033543676,0.066345476,-0.05197597,-0.003957387,0.06301974,0.022567835,-0.004119787,0.107944384,-0.018243244,-0.023943271,-0.072902374,-0.024406679,-0.05321228,-0.04333105,-0.011820712,-0.013944161,0.043364625,-0.019520318,-0.06321496,0.06873167,0.08416306,0.01621255,0.002474507,0.021622952,0.052418225,-0.0327022,0.05089931,-0.06465962,-0.01597373,-0.033093035,-0.060173392,-0.01831516,0.05760921,0.017084861,0.07414655,-0.08225469,-0.01864824,-0.004013992,0.048778594,0.023213666,0.092055365,-0.018469494,-0.046391286,0.064701244,-0.00812927,-0.053388346,0.028842112,-0.088642366,-0.08227046,-0.046928953,-0.050630476,-0.038962014,-0.009448999,0.012776501,0.041082222,0.22651574,0.046681814 +1.1.1.416,"The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.2.1.102, isopyridoxal dehydrogenase (5-pyridoxate-forming).",384,0.99999994,-0.04560851,-0.00014495345,-0.03722428,-0.019058648,0.09276685,0.050436758,-0.041032005,0.04241069,-0.004483566,0.009694258,-0.014797892,-0.08504397,-0.06778248,0.048671618,-0.031675104,0.0038184256,-0.11263656,-0.041176975,0.049018126,-0.07269395,0.037474755,0.024153627,-0.027000863,0.05403006,0.014291041,0.038664207,0.06960688,0.07856093,-0.04705408,-0.057508588,-0.002780581,-0.06192887,0.060228188,-0.024060508,0.038160667,0.12557855,-0.060152195,-0.04411104,0.046796728,0.036848158,0.0008417536,0.008167488,-0.063454606,-0.072210886,-0.04709709,-0.022682203,0.056741573,0.041099448,0.015876895,-0.03033331,-0.032999847,-0.022833366,-0.046982247,0.039832,0.041853424,-0.026766317,-0.010629671,-0.04932056,-0.025903724,-0.056096837,0.016938379,-0.017097654,0.043847274,0.018009955,-0.037284657,-0.09060844,0.043176033,-0.08321771,-0.009622291,-0.049967963,-0.082997754,-0.08434152,-0.0023564876,0.03159896,0.009692272,0.032998484,-0.0920659,-0.10227193,-0.024851456,-0.027842943,0.0036433202,-0.024947433,0.015630193,0.038517382,0.03614184,-0.017253373,0.054744013,-0.07091555,0.035505768,0.009530074,0.07733504,0.022640916,0.036341473,-0.0055495347,-0.018345866,0.07309922,0.01604259,0.101064146,0.025634032,-0.032197334,-0.05340371,0.101716995,-0.13345349,-0.05739952,-0.012240402,-0.014845597,0.025939941,0.13085996,0.010055921,-0.025886962,-0.026941404,-0.020514622,0.0065033785,-0.010095607,0.039483584,0.070777945,0.039818507,0.011920194,-0.04200794,0.06465107,0.035724394,-0.04381872,0.00929663,0.055419568,-0.036381446,-0.012282505,-0.093647555,1.1989467e-33,0.002089848,0.041026425,-0.009519612,0.014175322,-0.00016149253,-0.017821053,-0.10518355,0.046748627,-0.02588825,-0.060203068,-0.035549518,-0.00036685303,0.087605074,0.009814911,-0.030091815,-0.010061619,-0.074491546,-0.0034488908,0.021607243,0.012499001,0.04714291,-0.00017220285,-0.030294154,0.0650886,0.004090142,0.10389312,0.018788124,0.078000695,-0.035144843,-0.030551063,-0.0021507975,-0.049756754,-0.109493986,-0.019471541,0.04764114,-0.047975633,-0.03262579,0.016949208,-0.09100373,0.05844273,-0.016083661,-0.018988613,-0.02178695,-0.058913205,0.065795176,-0.07111103,-0.016048543,0.14371906,0.041514233,0.04985531,0.06710441,-0.010236417,0.10710955,-0.042223237,-0.0695468,0.029164217,-0.012489734,-0.07454665,0.05495766,0.021711968,0.09728381,0.029568551,-0.041821837,0.0008909766,0.017280065,0.0042742486,0.014465223,-0.07157341,0.04435954,0.02283555,-0.067842156,0.0063417796,0.06871571,-0.00052197423,0.027824817,-0.0014667388,-0.08804049,-0.029118175,0.004924128,0.014428113,-0.06599194,-0.022436585,0.05461794,-0.0323604,0.019577846,-0.037835933,-0.067181386,-0.046170183,0.021886943,0.05075117,0.02509571,-0.11398784,-0.090898156,0.053225476,-0.02531217,-1.7404397e-33,0.058628336,-0.054935616,0.0004422095,-0.04112013,-0.062665656,0.0659318,0.023749286,0.064963326,0.016142106,-0.021405425,0.07568097,-0.010805868,0.022538532,-0.014573142,0.06812011,0.03323603,-0.025344843,0.032295916,0.004328246,0.02936316,0.039288882,0.06113102,-0.027171442,0.0236678,0.07060586,0.07218769,0.0015138526,0.06143718,0.1278319,0.004478138,-0.017028753,-0.0039623836,0.005457047,0.029282944,-0.05641933,0.053998377,-0.07927498,0.027173663,0.072461806,0.009652928,0.07871892,0.009445823,-0.013122086,0.001038736,0.010908737,0.06094504,-0.04040736,0.0840371,0.03261463,-0.053669877,0.014845385,0.028558088,-0.032781504,-0.04335715,0.025980739,0.07308644,-0.04484109,0.02616423,0.041323483,0.045148518,0.01594619,-0.031474814,0.070436165,0.104794525,0.001586754,0.041593198,-0.045224242,0.056381665,0.0014260708,0.017580763,0.09842009,-0.0013080324,-0.021985153,0.015275167,-0.06877745,-0.057821326,-0.06326866,0.042527623,0.008871678,0.056415178,0.028457202,-0.039653353,-0.015908718,-0.08606178,-0.032154042,-0.078381985,-0.0032407076,0.055605426,0.033553682,0.039166827,0.0108359605,-0.04122103,-0.015823334,0.015812263,0.03761503,-3.272916e-08,0.029194336,-0.07290746,0.13105692,-0.046865363,0.086053714,0.01352119,0.025113106,-0.015603695,0.0655447,-0.015774516,0.02811266,-0.01626702,0.04942056,0.017702267,0.014949379,0.056667693,-0.026394412,0.026913341,0.0105876215,0.0084760655,-0.062159337,-0.07227637,-0.09345933,0.022654608,0.053685993,-0.0701552,0.0010717433,0.038768437,-0.058067247,-0.041173924,-0.021366034,0.0177013,0.0748452,-0.012869186,-0.0935017,0.03790891,-0.062583715,-0.05780151,-0.08120844,0.012039137,-0.024994288,-0.036634233,-0.09383162,-0.038193453,0.049230058,0.027651714,-0.056596566,-0.027721643,-0.054929063,-0.013036597,0.111259915,-0.002510041,0.021115135,-0.06275761,-0.10880405,0.026241628,0.011072789,-0.08801664,-0.013568914,-0.065334104,0.016853975,0.023564314,0.1650019,-0.04362929 +1.2.1.102,"The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.1.1.416, isopyridoxal dehydrogenase (5-pyridoxolactone-forming).",384,1.0,-0.053287774,0.0013800614,-0.040308405,-0.025477316,0.085844375,0.045009114,-0.043077886,0.041019917,-0.0021659422,0.005814971,-0.015236162,-0.095449865,-0.06864482,0.051296514,-0.028401123,0.0061633433,-0.12376739,-0.04494993,0.045321196,-0.07233161,0.033496078,0.032045186,-0.02846047,0.061725333,0.02082256,0.03686842,0.060368363,0.07335943,-0.045849312,-0.05475764,0.00016343353,-0.06578017,0.062741846,-0.022470267,0.04480605,0.12974313,-0.062703624,-0.04567623,0.046736933,0.041772597,0.0016467092,0.0027355123,-0.062847696,-0.07170524,-0.0594101,-0.021327535,0.05684585,0.05160178,0.024448955,-0.032228228,-0.02981654,-0.03207645,-0.052241214,0.037690368,0.044424072,-0.021296121,-0.005608549,-0.0452578,-0.025882894,-0.054063912,0.011152605,-0.014637852,0.046097662,0.021840973,-0.036605675,-0.08147753,0.040241823,-0.08464814,-0.004476235,-0.042733237,-0.08357739,-0.083233595,-0.008481625,0.03278998,0.0043586465,0.039684027,-0.09567402,-0.10048365,-0.022312496,-0.03793103,0.001148724,-0.015167334,0.01983238,0.04149721,0.034205843,-0.017419582,0.05302396,-0.07802281,0.046816655,0.010997776,0.07861691,0.020629462,0.040565234,-0.010666934,-0.014755636,0.069139466,0.015910048,0.09910644,0.016776534,-0.024364049,-0.055783894,0.09366271,-0.13429978,-0.046067625,-0.0084743975,-0.010973823,0.021798704,0.12717137,-0.0035663561,-0.021223752,-0.029430449,-0.030361574,0.011696652,-0.014352081,0.03254093,0.06467637,0.0339591,0.018534368,-0.04591648,0.058762413,0.036437664,-0.05044913,0.009409981,0.056070805,-0.03675943,-0.011789702,-0.09557847,1.7875678e-33,-0.002916215,0.039797742,-0.0129711535,0.010515902,0.0062467125,-0.02462614,-0.097354665,0.044956792,-0.031911943,-0.05654296,-0.036587436,0.010308992,0.085783,0.003924766,-0.03481705,-0.008148861,-0.074640304,0.003473009,0.0100062825,0.022493092,0.04926117,-0.0005849506,-0.022938155,0.058315814,-0.004899245,0.09986113,0.016123086,0.07523487,-0.038881566,-0.0329518,-0.0051947096,-0.05498453,-0.1162699,-0.031612232,0.049423188,-0.048195142,-0.028856507,0.0055041164,-0.097707234,0.06190192,-0.027017139,-0.01830367,-0.031587545,-0.060139325,0.06652497,-0.063365385,-0.019570302,0.14182319,0.03957315,0.043846548,0.06570382,-0.012488391,0.111080155,-0.03804268,-0.06804331,0.027168505,-0.0093562,-0.06957073,0.052403014,0.0116913365,0.09782703,0.03324942,-0.02822284,-0.0058386056,0.02086831,0.009071763,0.015703842,-0.07370678,0.039736502,0.020194443,-0.0691088,0.009237715,0.06333534,-0.0015797727,0.029272879,-0.00081756036,-0.08065638,-0.028725967,-0.0009528719,0.015030505,-0.06817226,-0.02280443,0.057801288,-0.036138397,0.016070932,-0.0310784,-0.06357697,-0.05262453,0.02010984,0.052922223,0.02211535,-0.11612418,-0.08270925,0.054189853,-0.025287319,-1.9625363e-33,0.050950527,-0.052431017,0.0019985528,-0.045799147,-0.06606894,0.0698584,0.01779576,0.06414851,0.015714707,-0.016520817,0.07340635,0.0006348358,0.0144640785,-0.017236006,0.06537726,0.035385434,-0.018593706,0.03320325,0.0026178374,0.032963265,0.039767016,0.060765933,-0.03439923,0.026187217,0.07179873,0.06723505,0.0003487417,0.06760327,0.1326881,-0.0065796003,-0.020097889,0.0060433005,0.009777615,0.019897068,-0.06359777,0.061895955,-0.07803114,0.024467288,0.082611345,0.0074107144,0.07011932,0.010725179,-0.009837297,0.0075669484,0.009362635,0.064881064,-0.048403576,0.08361697,0.030346286,-0.053688638,0.015489044,0.032856893,-0.0318971,-0.040201467,0.026460258,0.07428325,-0.03878093,0.038901854,0.037957672,0.044614114,0.02072003,-0.036335584,0.07105017,0.11216132,0.010983635,0.04043394,-0.04483023,0.05187436,0.0038919428,0.022630151,0.10500246,0.0024989643,-0.02350073,0.017627053,-0.05772651,-0.052749794,-0.055028856,0.034776792,0.010523749,0.05500732,0.017872375,-0.033575155,-0.016369127,-0.07857051,-0.023821672,-0.07358105,0.011304349,0.056964155,0.034749728,0.04319864,0.013371853,-0.037646018,-0.011610567,0.0149516985,0.040342804,-3.3026822e-08,0.036780648,-0.073867805,0.12896988,-0.040737055,0.08875739,0.009260222,0.028460987,-0.016097078,0.06211218,-0.020751996,0.024837907,-0.02161133,0.0570769,0.01686943,0.019901179,0.054904148,-0.027615085,0.0325651,0.0051196753,0.012047141,-0.05622035,-0.067472406,-0.08931476,0.016176132,0.05922681,-0.0809181,0.009259885,0.048197668,-0.06251791,-0.03489713,-0.02544738,0.015577087,0.07514932,-0.00793404,-0.08154755,0.04977906,-0.075704515,-0.051350135,-0.080348015,0.0015013738,-0.03357721,-0.039831348,-0.0810329,-0.040533993,0.043169346,0.037184536,-0.05521977,-0.01697827,-0.04532612,-0.010126698,0.11115317,-0.00078292785,0.027337557,-0.065917104,-0.10985698,0.024876244,0.013432745,-0.087076634,-0.0061953086,-0.062903754,0.017460778,0.016492914,0.1646016,-0.053563192 +1.14.14.166,"This cytochrome P-450 (heme-thiolate) enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.",384,1.0,-0.009564984,0.03537997,-0.07229019,-0.015203927,0.044109493,0.080183,-0.048566915,0.09196854,0.03681352,-0.06107701,-0.004928738,-0.011150117,-0.02565452,-0.026869582,-0.039796043,0.014587887,-0.06992038,0.016430447,0.026896978,-0.07177343,7.560858e-05,0.052244585,0.064704895,0.03993063,-0.013374206,0.060968813,-0.021531306,0.061592158,0.015155475,-0.055413928,0.030511409,0.009314402,0.028448578,-0.022989416,-0.07130161,0.073219836,-0.09438196,-0.012015429,0.06379899,0.014366676,0.09665473,-0.0653687,-0.1084039,0.045675106,-0.013624404,-0.0094741,-0.017125854,0.029750412,0.015051381,-0.034703936,-0.0034568168,-0.052718714,-0.05724097,0.066154644,-0.037240796,-0.006241532,0.055009767,-0.0055579166,-0.009962705,0.017645495,-0.0276168,0.06472436,-0.00095609966,0.034606047,0.06277259,-0.0011279323,0.001646561,-0.01735691,0.03971703,-0.0636717,-0.03429826,-0.09662464,-0.024395138,0.014463305,-0.11174189,0.08444789,-0.08216957,0.03324974,-0.01649983,0.013174877,0.100232385,0.02769367,-0.027420996,0.11180044,-0.00941521,-0.021319382,-0.055065967,0.061952963,0.020835496,-0.03145941,0.017635128,0.04274458,-0.10860571,0.010094316,-0.10121072,0.011311014,0.06907596,0.040031917,-0.03385075,-0.030428644,0.059265178,0.076578595,-0.098499455,-0.11340335,-0.03347179,-0.022586906,-0.023051372,-0.044253685,0.04891828,-0.0351266,-0.052537408,-0.07841686,-0.06258883,-0.0013114719,-0.029093826,0.07325233,0.02151567,-0.028396307,-0.0467902,-0.044845823,-0.089776784,0.009315687,0.0269098,0.01027856,-0.019509958,-0.008830788,-0.08700759,1.9994505e-33,0.037150517,0.053603683,-0.014507374,-0.021864984,0.0012488876,-0.042244606,-0.007855418,0.05114517,-0.05645097,-0.033437695,-0.06750607,-0.0798045,-0.03383143,0.0021764764,0.035212297,-0.029514672,-0.06876156,-0.0038893553,0.06674712,-0.051131666,-0.059760112,-0.0053581563,-0.076032534,0.017366493,0.024616627,0.13352647,-0.036328427,-0.0129107125,0.034818936,-0.011081503,0.004255225,-0.003089191,-0.050228767,-0.07378053,0.016462209,-0.022593696,-0.048095033,-0.005718754,-0.08512264,0.03469674,-0.040861145,-0.0131086195,0.09490933,-0.034520634,-0.0053362115,-0.03260875,-0.13066839,0.06429464,0.069824584,0.041084282,0.048410233,-0.052215617,0.038101375,0.05168112,-0.04956399,0.03459,-0.017712334,0.02882275,-0.030576177,0.03809238,0.09044237,-0.012198908,-0.013256712,0.08794794,0.069633074,0.052834164,-0.06460329,-0.009324545,0.024854697,0.13080178,-0.035447177,0.012316543,0.010183552,0.033157527,0.024797395,0.03534199,0.025419643,0.052093007,0.05203583,-0.011733988,0.018441148,-0.05488037,0.005164948,-0.015985973,-0.010436406,-0.010587984,0.07425053,0.018955834,-0.04763436,0.08429458,0.01960523,-0.038062036,-0.04225,-0.016001258,-0.017621584,-2.4599945e-33,0.08365948,-0.06971525,-0.0022810928,-0.059518386,-0.026654726,0.08380191,-0.067567356,0.026106738,-0.029389782,0.096857086,0.05212144,-0.022785634,0.083507895,0.015632896,-0.0358348,-0.054392096,0.0035342192,0.06540767,-0.009911734,0.050186127,-0.019825013,0.042167764,-0.019306572,0.031433463,0.014901783,0.007523758,0.046528973,-0.00034120237,0.037132487,0.044558432,0.022765046,0.04134203,-0.07322846,-0.024368934,-0.025502682,0.08875052,0.06628869,0.03224924,0.011262223,0.021762699,-0.039755255,0.013731043,0.032729797,0.03257457,0.048023917,0.027101837,-0.0809816,0.008383651,0.007009009,-0.019608041,0.063168086,0.055683095,-0.007979445,0.051871456,-0.02137302,-0.007329198,-0.04986279,-0.09077916,-0.033806983,-0.1399095,0.013905727,-0.011246881,-0.05747049,-0.016069822,0.018908408,0.02958286,-0.058391694,0.023237573,0.012929916,0.01168206,0.062167518,-0.03738556,0.03910106,0.09899607,-0.04379247,-0.023336465,0.0052888077,0.0047856756,0.060639717,-0.028050479,0.017728748,-0.004089237,-0.006896412,-0.041281283,-0.02391979,-0.049767125,-0.019576572,0.148287,0.0344156,-0.014189025,0.007504788,0.050998304,-0.12224576,0.0443289,0.034180027,-3.0199935e-08,0.005405054,-0.09937056,0.046135142,0.030306844,0.008218218,0.030336117,0.024103412,-0.058284834,0.01644021,-0.055036634,0.03068793,0.060131144,-0.051247474,0.027253157,0.008339019,-0.009089033,0.03301341,0.075249806,0.023056101,-0.0045375763,-0.08120098,0.010335993,-0.020281123,-0.04881095,0.074426115,-0.060232174,0.020390546,0.044101,0.035895552,0.0106486315,0.059271928,0.010802321,-0.034762874,-0.04153998,-0.021954775,0.08940358,0.011526959,-0.07069259,0.022956071,-0.03383002,-0.011784727,-0.059380274,-0.08318362,0.0036237969,-0.017109828,-0.02030472,0.0793955,0.002516862,0.01940924,-0.034034498,-0.05201988,0.0021780594,0.06477327,-0.09100182,-0.099519506,0.024294872,0.042290993,-0.027719757,-0.016825585,-0.14095119,0.04591879,-0.008336391,0.22523263,0.035252128 +1.14.14.167,"This cytochrome P-450 (heme-thiolate) enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.",384,1.0,-0.009564984,0.03537997,-0.07229019,-0.015203927,0.044109493,0.080183,-0.048566915,0.09196854,0.03681352,-0.06107701,-0.004928738,-0.011150117,-0.02565452,-0.026869582,-0.039796043,0.014587887,-0.06992038,0.016430447,0.026896978,-0.07177343,7.560858e-05,0.052244585,0.064704895,0.03993063,-0.013374206,0.060968813,-0.021531306,0.061592158,0.015155475,-0.055413928,0.030511409,0.009314402,0.028448578,-0.022989416,-0.07130161,0.073219836,-0.09438196,-0.012015429,0.06379899,0.014366676,0.09665473,-0.0653687,-0.1084039,0.045675106,-0.013624404,-0.0094741,-0.017125854,0.029750412,0.015051381,-0.034703936,-0.0034568168,-0.052718714,-0.05724097,0.066154644,-0.037240796,-0.006241532,0.055009767,-0.0055579166,-0.009962705,0.017645495,-0.0276168,0.06472436,-0.00095609966,0.034606047,0.06277259,-0.0011279323,0.001646561,-0.01735691,0.03971703,-0.0636717,-0.03429826,-0.09662464,-0.024395138,0.014463305,-0.11174189,0.08444789,-0.08216957,0.03324974,-0.01649983,0.013174877,0.100232385,0.02769367,-0.027420996,0.11180044,-0.00941521,-0.021319382,-0.055065967,0.061952963,0.020835496,-0.03145941,0.017635128,0.04274458,-0.10860571,0.010094316,-0.10121072,0.011311014,0.06907596,0.040031917,-0.03385075,-0.030428644,0.059265178,0.076578595,-0.098499455,-0.11340335,-0.03347179,-0.022586906,-0.023051372,-0.044253685,0.04891828,-0.0351266,-0.052537408,-0.07841686,-0.06258883,-0.0013114719,-0.029093826,0.07325233,0.02151567,-0.028396307,-0.0467902,-0.044845823,-0.089776784,0.009315687,0.0269098,0.01027856,-0.019509958,-0.008830788,-0.08700759,1.9994505e-33,0.037150517,0.053603683,-0.014507374,-0.021864984,0.0012488876,-0.042244606,-0.007855418,0.05114517,-0.05645097,-0.033437695,-0.06750607,-0.0798045,-0.03383143,0.0021764764,0.035212297,-0.029514672,-0.06876156,-0.0038893553,0.06674712,-0.051131666,-0.059760112,-0.0053581563,-0.076032534,0.017366493,0.024616627,0.13352647,-0.036328427,-0.0129107125,0.034818936,-0.011081503,0.004255225,-0.003089191,-0.050228767,-0.07378053,0.016462209,-0.022593696,-0.048095033,-0.005718754,-0.08512264,0.03469674,-0.040861145,-0.0131086195,0.09490933,-0.034520634,-0.0053362115,-0.03260875,-0.13066839,0.06429464,0.069824584,0.041084282,0.048410233,-0.052215617,0.038101375,0.05168112,-0.04956399,0.03459,-0.017712334,0.02882275,-0.030576177,0.03809238,0.09044237,-0.012198908,-0.013256712,0.08794794,0.069633074,0.052834164,-0.06460329,-0.009324545,0.024854697,0.13080178,-0.035447177,0.012316543,0.010183552,0.033157527,0.024797395,0.03534199,0.025419643,0.052093007,0.05203583,-0.011733988,0.018441148,-0.05488037,0.005164948,-0.015985973,-0.010436406,-0.010587984,0.07425053,0.018955834,-0.04763436,0.08429458,0.01960523,-0.038062036,-0.04225,-0.016001258,-0.017621584,-2.4599945e-33,0.08365948,-0.06971525,-0.0022810928,-0.059518386,-0.026654726,0.08380191,-0.067567356,0.026106738,-0.029389782,0.096857086,0.05212144,-0.022785634,0.083507895,0.015632896,-0.0358348,-0.054392096,0.0035342192,0.06540767,-0.009911734,0.050186127,-0.019825013,0.042167764,-0.019306572,0.031433463,0.014901783,0.007523758,0.046528973,-0.00034120237,0.037132487,0.044558432,0.022765046,0.04134203,-0.07322846,-0.024368934,-0.025502682,0.08875052,0.06628869,0.03224924,0.011262223,0.021762699,-0.039755255,0.013731043,0.032729797,0.03257457,0.048023917,0.027101837,-0.0809816,0.008383651,0.007009009,-0.019608041,0.063168086,0.055683095,-0.007979445,0.051871456,-0.02137302,-0.007329198,-0.04986279,-0.09077916,-0.033806983,-0.1399095,0.013905727,-0.011246881,-0.05747049,-0.016069822,0.018908408,0.02958286,-0.058391694,0.023237573,0.012929916,0.01168206,0.062167518,-0.03738556,0.03910106,0.09899607,-0.04379247,-0.023336465,0.0052888077,0.0047856756,0.060639717,-0.028050479,0.017728748,-0.004089237,-0.006896412,-0.041281283,-0.02391979,-0.049767125,-0.019576572,0.148287,0.0344156,-0.014189025,0.007504788,0.050998304,-0.12224576,0.0443289,0.034180027,-3.0199935e-08,0.005405054,-0.09937056,0.046135142,0.030306844,0.008218218,0.030336117,0.024103412,-0.058284834,0.01644021,-0.055036634,0.03068793,0.060131144,-0.051247474,0.027253157,0.008339019,-0.009089033,0.03301341,0.075249806,0.023056101,-0.0045375763,-0.08120098,0.010335993,-0.020281123,-0.04881095,0.074426115,-0.060232174,0.020390546,0.044101,0.035895552,0.0106486315,0.059271928,0.010802321,-0.034762874,-0.04153998,-0.021954775,0.08940358,0.011526959,-0.07069259,0.022956071,-0.03383002,-0.011784727,-0.059380274,-0.08318362,0.0036237969,-0.017109828,-0.02030472,0.0793955,0.002516862,0.01940924,-0.034034498,-0.05201988,0.0021780594,0.06477327,-0.09100182,-0.099519506,0.024294872,0.042290993,-0.027719757,-0.016825585,-0.14095119,0.04591879,-0.008336391,0.22523263,0.035252128 +1.14.14.168,"A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower). The cyclisation of 8beta-hydroxygermacra-1(10),4,11(13)-triene-12-oate to inunolide (12,8beta) does not seem to occur spontaneously. The enzyme from Inula hupehensis also forms some 8alpha-hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8alpha) (cf. EC 1.14.14.170 8-epi-inunolide synthase).",384,1.0,-0.12384728,0.071941525,-0.07150663,-0.045718633,0.05550916,0.05280742,-0.025906468,0.061825946,0.0556735,0.029859046,0.035428304,-0.0038301048,-0.032939307,-0.032315254,-0.096361175,0.010847546,-0.039145876,-0.0048958254,-0.012614962,-0.01247523,0.01404216,0.012107189,-0.004570292,0.03911494,0.008153727,-0.039119318,-0.012368987,-0.004784646,-0.09742277,-0.061548524,-0.0126931,-0.0016262546,0.017633269,-0.005033526,-0.005218662,0.12923199,0.010848843,-0.100984894,0.048793267,-0.04618694,0.037677523,-0.021126108,-0.06675556,-0.027684517,-0.03884708,-0.041824672,-0.03907695,0.0060219727,0.0697267,-0.0627975,-0.03668693,-0.05359583,0.010822031,0.0046472587,-0.042411834,0.008528178,-0.09532736,0.045925748,-0.001700727,-0.002035726,-0.009795565,0.0063337516,-0.00845741,0.089070834,-0.06416381,-0.08407201,0.0019585667,0.027856806,-0.053427115,0.046088453,0.054370478,-0.020509884,-0.04219565,0.06628481,0.00054943777,0.12770715,-0.01812304,0.022398163,-0.022766016,-0.05469919,0.024363136,-0.012556596,-0.015535772,0.07223301,0.052304104,-0.049098298,0.0043885894,0.07152344,0.040657155,0.026564011,0.0014140892,0.04782365,-0.007064814,0.015199503,-0.051492944,0.04143592,0.04344565,-0.043809798,0.049741846,-0.012721089,0.030619724,-0.000436737,0.00373257,-0.04947142,-0.03136245,0.03889617,-0.023925707,-0.015666712,0.09036855,-0.029935174,-0.028870828,-0.037401356,0.06661102,-0.03326983,-0.055952605,0.059005436,-0.056207046,-0.04881383,-0.020357806,-0.013237556,-0.05627431,-0.023352785,-0.00021185962,0.04153257,-0.040653903,0.07183737,-0.084383756,8.700442e-34,0.097545855,0.035724502,-0.010422048,-0.0016462735,0.018346159,-0.024713486,-0.0030470104,0.06946047,-0.05939303,-0.052255865,-0.10067727,-0.050767984,0.07413253,-0.054691773,-0.017416853,0.0013234942,0.027698863,0.03618429,0.074905396,-0.023785284,-0.07575943,-0.03446921,-0.086098365,-0.012731711,-0.014124995,0.09385017,-0.006791498,-0.047783814,0.03756855,0.0012525504,0.016229533,-0.102413826,-0.04998648,0.052962713,0.05484169,-0.06803499,0.045486465,-0.038563184,0.032588035,-0.0041902764,-0.020887153,-0.009963602,0.02281483,-0.08471426,0.05408586,-0.008992895,-0.08794426,0.056660276,0.059408415,0.046820514,0.024158383,0.0037654678,0.11611457,0.055991918,-0.082356036,0.089928076,0.025870075,0.028059693,0.057738226,0.056113966,0.022710111,0.09252848,-0.00876777,-0.006103028,0.01591819,0.03504718,-0.07459777,-0.0014044266,-0.104343265,0.085873514,-0.06475981,-0.038485847,-0.022299673,-0.012951446,0.120608576,0.022248693,-0.026590643,0.023213036,0.041660987,0.076844424,0.05840412,-0.027313894,0.025284689,0.00086340046,-0.03003269,0.039377693,0.04319776,0.0320077,-0.048408784,0.08907484,0.12745228,-0.07109154,-0.00037543842,-0.01778285,-0.012343691,-2.671532e-33,0.016437475,0.019369652,0.01734045,-0.095937885,-0.014033491,0.061383225,-0.0012840764,-0.029235413,-0.0100940885,-0.046362944,0.105318315,-0.03588286,0.016239967,-0.04542316,-0.08896571,-0.017347522,-0.016870897,0.13788019,-0.043595955,-0.039074693,-0.0863655,-0.012308019,0.0017310343,0.020580895,-0.004296749,-0.02358141,0.045299605,0.040650543,0.0051205843,0.07555219,0.0443286,0.030145068,-0.062326595,0.016955227,-0.027247656,0.04544522,-0.045907065,-0.124286555,0.06710228,0.022839822,-0.015481179,-0.04126482,0.024172269,0.032760873,0.068277925,0.07975767,-0.049263243,0.12064384,-0.050956864,0.070502244,-0.03784614,0.053577155,-0.013550295,0.03440255,0.0066472255,-0.02371201,0.038496483,-0.014835142,-0.04930046,-0.056368336,0.049886517,-0.040287673,0.002739291,0.092940696,-0.017065793,0.10084858,-0.04627285,0.06515483,-0.02454115,0.06954671,0.025348755,-0.019752884,-0.011583234,0.0064534815,0.020652747,0.030898169,0.019188048,-0.07447434,0.011832605,-0.058246866,-0.057696868,0.022706049,0.018357262,-0.077594735,-0.011679684,-0.08148052,-0.03213407,0.009323622,0.04235652,0.0030433007,0.0038352108,0.05601146,-0.015173911,0.03736649,0.041602526,-4.4470642e-08,0.060303662,-0.082610354,0.03989549,-0.055537634,0.01104122,-0.014334163,0.02414957,-0.020088756,0.07458397,-0.062379178,-0.032956984,0.05977371,-0.002764852,-0.049620256,-0.0014876805,-0.06456219,0.05767072,0.088025816,-0.0013853366,0.045523304,-0.032432575,0.0066919182,-0.020768488,-0.032032806,0.033190556,-0.09683851,0.05808948,-0.013925551,0.047893904,-0.025188856,-0.02664601,0.06242968,-0.04798388,-0.015336937,-0.022141615,0.056961007,-0.05418274,0.043085925,1.4190178e-05,-0.08050451,-0.020410743,-0.019902382,-0.10588557,-0.009910353,0.036535624,0.018368492,0.023311509,0.028853588,0.037882328,-0.06278119,-0.066683024,0.030571545,0.072600946,-0.15183915,-0.07134157,-0.044998895,0.0038016704,-0.03986735,-0.030966852,-0.090026096,-0.032673072,-0.032623287,0.154656,0.005397875 +1.14.14.169,A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower).,384,1.0,-0.08716712,0.100442916,-0.06318731,-0.03839078,0.07995101,0.07543554,-0.004101307,0.054834723,0.0009659703,-0.0029206427,0.02987008,-0.0464128,-0.073476635,-0.025522333,-0.027245887,-0.009063434,0.02603448,0.02287385,-0.0025010803,-0.06608845,-0.020362353,0.07036638,-0.0013217173,0.025156988,0.018943876,0.015966583,-0.032525484,0.034627646,-0.06763693,-0.05363161,-0.048077397,-0.0033430844,0.080287114,-0.018492183,-0.01267253,0.08174751,-0.01680601,-0.12362511,0.044767324,-0.060346417,0.09590162,-0.027770292,-0.051790617,1.0756854e-05,-0.067869544,0.025782801,-0.039895035,0.026800085,0.08073254,-0.049621757,-0.023856072,-0.007976221,-0.02884082,-0.011567319,-0.06910697,-0.0026411575,0.02829925,0.045555983,-0.051225256,-0.009682283,-0.01900717,0.012850966,0.0038071736,0.05548424,-0.005546639,-0.052157078,-0.039711338,0.0009811311,0.018764406,-0.049422186,0.00083173136,-0.055483565,-0.031021817,0.0114649935,-0.09079518,0.1565434,-0.022339448,0.027118692,0.022539256,-0.039105937,0.025263973,0.037578598,-0.053570304,0.14200503,0.016494913,-0.01458228,-0.044704292,0.08347946,-0.030912347,-0.03759072,-0.0015524758,0.017225243,-0.06533051,0.000671572,-0.09279776,0.0414448,-0.00010967023,-0.040924713,-0.033282794,-0.030386332,0.06859262,0.07148139,0.031702615,-0.09470507,-0.059404597,0.035826486,-0.05071344,0.022507155,0.07379268,-0.067348495,-0.04232278,0.00059593044,-0.02229187,-0.06173215,-0.0043244385,0.01513856,-0.046827186,-0.014852283,-0.045660432,-0.0107829645,-0.06315989,-0.057428855,0.026381016,0.019105636,-0.036292456,-0.020493096,-0.10059534,8.441878e-34,0.0761332,0.09675171,0.016811127,-0.011845465,-0.038332827,0.011114907,-0.0641115,0.0720746,-0.043420188,-0.03012933,-0.097950965,-0.068240225,0.0587203,-0.026409766,-0.03695644,-0.01076583,-0.05612024,0.022808183,0.06330433,-0.011175335,-0.08890118,0.037171476,-0.05649416,-0.032904048,0.02974417,0.060763657,-0.0048668124,-0.057185598,-0.014096603,0.0016461958,0.0018224062,-0.051720284,-0.023397017,0.006062291,0.068629526,-0.060862005,-0.0065838736,-0.064760335,-0.041582108,0.04292272,-0.009999515,0.023508824,0.093202785,-0.024036093,0.0039038942,-0.012050697,-0.103181474,0.05427535,0.030196715,0.045734294,0.022431942,-0.046733327,0.12902354,0.017042752,-0.064174294,0.0016738313,0.031252313,0.077439636,-0.01310457,0.066438705,0.0652736,0.07072579,-0.07083457,0.0446706,0.057984997,0.086405665,-0.10263121,0.011353691,-0.02644471,0.08957185,-0.003493573,-0.04143885,0.05007063,-0.03729344,0.052990444,0.025248101,0.025751725,0.064074345,0.03702113,0.07171413,0.042757027,-0.042920467,-0.02662746,-0.056502324,-0.03504863,0.03315159,0.059805155,0.026338326,0.01614575,0.03531425,0.11448707,-0.072512925,0.022825165,-0.00040149665,-0.04982882,-1.6160599e-33,0.012518981,-0.008354454,-0.016031953,-0.053609155,0.011422154,0.011839865,0.014025429,-0.03367024,-0.0052036475,0.0023486502,0.119101256,-0.051728085,0.021480542,-0.03643086,-0.057989042,0.0047400547,-0.0025464366,0.065093465,-0.02310611,0.050203692,-0.08231064,-0.01817038,0.025731664,0.010837867,0.032307535,0.021372886,0.008496934,-0.030803949,0.032920662,0.007962364,0.028449858,0.062128134,-0.10034264,-0.043671455,0.01902628,0.016108332,0.012323197,-0.02532979,0.09051842,0.045924734,-0.048174612,0.06929152,0.05830123,0.0008500784,0.06418979,0.06702504,-0.09218611,0.0325795,-0.094804026,0.08113375,0.0024629266,0.012871698,0.0024267165,0.037502147,-0.046095993,-0.017910982,-0.0039799516,0.033818327,-0.049514428,-0.04419193,0.03832139,-0.042865507,0.016545186,0.11370515,-0.054629505,0.07334237,-0.045694415,0.033909857,-0.032329958,0.07585749,-0.011912334,-0.024957642,0.078990564,0.06422811,0.014003128,0.052672215,0.05110239,-0.013533681,0.01870616,0.008845682,0.004124975,0.016969075,-0.040176168,-0.07183992,-0.0058718026,-0.052771386,-0.08839636,0.07542461,0.035872348,-0.035910014,-0.025629954,0.0742973,-0.04527635,0.03599781,0.08816621,-2.5660407e-08,0.025036316,-0.0987432,0.04578673,-0.02835515,0.06980506,0.022585606,0.025703797,-0.023858724,0.05781801,-0.007141853,0.006827106,0.053772524,-0.06804148,-0.07945639,-0.027577948,-0.03546394,0.06695412,0.026328105,0.046641566,0.039531026,0.00069812615,0.0017484504,-0.031917997,-0.036049455,0.06569289,-0.09736287,0.057958443,-0.030953387,0.06748129,0.002725717,0.024333593,0.062127046,-0.061150674,-0.07207078,0.027210945,0.06389475,-0.027168935,0.0029009758,-0.044943072,-0.050759178,-0.014871104,-0.0055387076,-0.052475873,-0.025298284,0.039750334,-0.012306601,0.04759937,0.08188615,-0.05177277,-0.055378307,-0.05755218,0.0071503953,0.026323754,-0.12952262,-0.10035177,-0.041605383,0.06992292,-0.021523055,-0.030743334,-0.08596431,-0.041176535,0.007317386,0.15425417,0.0118046235 +1.14.14.170,"A cytochrome P-450 (heme-thiolate) protein from the plant Inula hupehensis. The enzyme also produces 8beta-hydroxygermacra-1(10),4,11(13)-triene-12-oate (EC 1.14.14.168, germacrene A acid 8beta-hydroxylase).",384,1.0,-0.08881702,0.0497958,-0.080220506,-0.013440096,0.0505556,0.07405965,0.03527158,0.0924001,0.037150044,0.017518872,0.042671844,-0.019471284,-0.072614454,-0.03329735,-0.095421664,-0.0011274304,-0.034714542,-0.0220662,0.03923012,-0.071599714,0.07513169,0.06099307,0.021344952,0.017468657,0.039408855,-0.073156975,0.031341966,0.031865444,-0.05260351,-0.07671855,-0.02857155,-0.0066647087,0.071863934,-0.005319349,-0.018148785,0.11417941,0.0030877173,-0.13110025,0.022877054,-0.008638399,0.078352645,0.022253808,-0.051818956,0.026105585,-0.07321012,-0.03108784,-0.0156244645,0.018679928,0.07046392,-0.04478038,-0.07341244,-0.034598526,0.020728244,-0.013586298,-0.022917703,0.002979884,-0.042951535,-0.011247743,-0.005385911,-0.00040177038,0.013211855,0.016475214,-0.016064256,0.026919223,-0.027159687,-0.06399093,-0.021671569,-0.0103375595,-0.040064506,-0.0256213,0.003408234,-0.048991892,-0.013513801,0.07292823,-0.038499605,0.052196134,-0.050454184,0.019846797,0.022989418,-0.021799834,0.021238504,0.027453505,0.02355788,0.10080903,0.052403104,-0.024441497,0.030067587,0.10546217,0.013264438,-0.012151828,-0.0031925603,0.036669847,-0.061256163,0.00940676,-0.1045899,0.054121964,0.054466814,-0.053416908,0.004330571,0.0031117396,0.06829021,0.011184808,0.042437527,-0.10198325,-0.08984013,0.030946666,-0.027771028,0.035989054,0.11703762,-0.019886367,-0.05918787,-0.040565237,0.055565704,-0.048307195,-0.050204843,0.051572062,-0.029704625,-0.05316002,-0.0030689018,-0.05402237,-0.03210106,-0.02247078,0.03008427,0.02802401,-0.08008643,0.09678614,-0.10465047,7.215391e-34,0.11017595,0.009698803,-0.011685312,0.027123671,0.006137457,0.004892314,-0.023008432,0.06166159,-0.047939997,-0.05273053,-0.14401335,-0.08512155,0.005470237,-0.016945612,0.013672993,-0.008861546,-0.029923556,0.018204244,0.09668931,0.030528896,-0.071592115,-0.01140266,-0.07511714,0.010363916,0.039023854,0.055841528,0.015588722,-0.04068925,0.029460296,-0.0039929315,0.03229111,-0.06510693,0.0035057962,-0.036346424,-0.0013063524,-0.0639229,0.04227928,-0.010443879,-0.007794704,0.021763597,0.050012756,0.012358858,0.08946176,-0.08341475,0.052896805,0.014785153,-0.09965735,0.032403715,0.050630055,0.084602185,0.04949246,-0.018358793,0.11400298,0.06284656,-0.07775842,0.076709084,-0.02775759,0.077856965,0.08170403,0.03906494,0.034428075,0.10137245,-0.011304274,0.02363308,-0.012700592,0.053753544,-0.08887812,-0.022464992,-0.060280465,0.11174415,-0.110303104,-0.029970013,0.010029412,-0.04805948,0.029396852,0.0025824062,-0.06324562,-0.0035787558,0.020338994,0.052314844,0.032127094,-0.015806952,0.016604898,-0.013646352,-0.007701867,0.00050516083,0.00514582,0.03049627,-0.03471309,0.02848462,0.04992855,-0.05926417,-0.0025570134,-0.018613009,-0.02830473,-1.4792382e-33,0.06689157,-0.061820835,0.064715564,-0.08420746,-0.019784953,0.09561395,0.032216124,-0.065089926,-0.035490714,-0.028926898,0.11294149,-0.048682112,0.04148146,-0.038094763,-0.004218996,0.00223528,-0.06279265,0.09398557,-0.018794397,-0.0038568443,-0.05340316,0.04132343,0.013421302,0.016897958,-0.010219066,0.02022808,0.039304756,0.013039519,0.012106445,0.020595385,0.008004182,-0.00216791,-0.046349548,0.010928507,-0.1011895,-0.009161764,0.008284104,-0.10716271,0.026310885,0.04568648,0.017415622,0.016012192,0.07103155,0.07603868,0.039399315,0.05911011,-0.03681311,-0.009781869,-0.05528366,0.010878827,0.017743573,0.011339029,-0.047220625,0.027416192,-0.02623216,-0.05372615,-0.025882008,0.009811378,-0.05760821,-0.047019325,-0.024148067,0.00025458087,0.012389527,0.07594857,0.016952533,0.11702887,-0.046705358,0.049834926,-0.008500692,0.032113828,0.028464092,-0.0033077674,-0.005298749,0.07897114,0.03764582,0.012228603,-0.027105907,-0.01758255,0.005406617,-0.013736709,-0.020469636,-0.013336862,-0.05438714,-0.058473654,-0.0013909254,-0.07364373,-0.032330617,0.049623206,0.09199108,0.0387978,-0.028326176,0.099625595,-0.044028915,0.01848794,0.0673316,-3.915835e-08,0.030027919,-0.09000336,0.02567346,-0.05559421,-0.031558227,-0.026233189,0.043292195,0.017394496,0.080965266,-0.0581469,-0.0115650045,0.06803168,-0.06879013,-0.009840484,0.038820896,-0.035933424,0.004837289,0.11278334,0.028594274,0.03510695,-0.06506022,0.020942628,-0.028942134,0.052628513,0.01028427,-0.10969654,-0.006780719,-0.028525595,0.075220466,-0.017654326,-0.009216212,0.058477744,-0.03774187,-0.012828516,-0.0077743786,0.041696608,-0.068217,-0.0033928296,-0.018778054,-0.012420095,0.034798007,-0.051593702,-0.074160926,-0.045432873,-0.015095963,0.015056328,0.041551497,0.051092986,0.04400707,-0.048077796,-0.053600796,0.030556103,0.022708833,-0.11951705,-0.11564763,-0.044126406,0.016849931,-0.065845326,-0.018949667,-0.09581614,-0.007992857,0.013397862,0.17300451,0.028718298 +1.14.19.76,"A cytochrome P-450 (heme-thiolate) protein found in plants. The rice enzyme channels flavanones to the biosynthesis of tricin O-linked conjugates. cf. EC 1.14.20.5, flavone synthase I.",384,1.0,-0.07676514,-0.016134094,-0.1150153,-0.014220536,0.06908613,0.10405195,-0.037723664,0.056211695,0.04230325,-0.013002323,0.12838972,-0.042314302,-0.0006288443,-0.046460237,-0.053356756,-0.0066364356,-0.050375447,0.049606428,-0.047111668,-0.110751756,0.0037078264,0.039550114,0.009909363,-0.010087572,0.016178854,-0.044151038,0.023908803,0.0071094865,-0.03095303,-0.08865907,-0.041013878,0.047499508,0.014109787,0.013057087,0.0020038253,0.07848767,-0.014645842,-0.10251034,0.103246346,-0.016630845,0.045293823,-0.02937381,0.014615774,-0.012142327,0.038414516,0.0012561188,-0.023857802,-0.0022343667,0.027277524,-0.02939976,-0.023244262,0.01952658,-0.0318773,0.05011841,-0.006558702,-0.0351238,0.045369178,0.046103716,-0.047072005,0.07777851,0.023700383,0.026832424,0.026591418,0.014011658,-0.067157865,-0.034105603,-0.08436342,0.037544403,0.035049357,-0.05343701,-0.024651125,-0.08995389,0.00216517,0.021598747,-0.08328528,0.07229876,-0.03003089,0.06232004,-0.03192543,-0.029615777,0.054522894,-0.027949212,0.042214494,0.07591833,0.04043094,0.0008695183,-0.09495571,0.048245665,0.029252885,0.02459319,0.025464578,0.076737575,-0.0051373327,0.019068038,-0.049223192,0.062571846,0.037296038,-0.019325048,-0.02602321,-0.064183764,0.04424704,0.016723415,0.013587858,-0.0419219,-0.03474943,-0.016432337,0.004260991,0.039475344,0.050194252,-0.037359677,-0.008280371,-0.04705276,-0.02279642,-0.066230245,-0.022253111,0.080739394,0.0077665094,-0.058186974,-0.05386368,-0.065050505,-0.03471675,0.029037826,0.005075411,0.037160754,-0.021425286,-0.027939705,-0.11316181,2.653441e-33,0.09933625,0.08500869,-0.06555227,-0.0050294986,-0.011023891,-0.08262486,0.011377131,-0.016668633,-0.028980495,-0.042284854,-0.11467542,-0.052448362,-0.042730656,-0.062017765,0.0070036626,0.031159006,-0.07200612,-0.034543104,0.015778376,-0.04430219,-0.050015945,-0.008283956,-0.07427809,0.0015728609,0.07901454,0.08188966,-0.02475696,-0.098951824,0.031921387,-0.0062478385,-0.035767402,-0.07170271,0.017202027,0.009567543,0.030825645,-0.0553618,-0.028035494,-0.017716201,-0.06542658,0.09478658,0.010245721,-0.007304757,0.05865904,-0.054142326,0.055575874,0.015274119,-0.0996354,0.05810877,0.01568457,0.035835996,0.032552272,-0.008660912,0.11013384,0.104785845,-0.050370466,0.01585303,-0.023389326,0.0232826,-0.0073209186,0.10254283,0.022512875,0.034907527,-0.05106748,0.049375795,-0.03857816,0.05879387,-0.09426815,-0.07057286,0.04976899,0.1470065,-0.0393379,-0.12215121,0.040643,-0.03627502,0.1087215,-0.00912543,-0.03700886,-0.03352035,0.01159885,0.059095085,0.079558656,-0.013429403,-0.009103295,0.026018472,-0.0394226,0.016978838,-0.020409761,-0.006302035,0.036217567,0.047553934,0.09072822,-0.03367861,0.04422951,0.0142740095,-0.035698097,-1.5683611e-33,0.051440444,-0.013812289,0.031961266,-0.040815324,-0.059734542,0.026224269,-0.046593994,-0.10728215,0.0184224,0.001570092,0.062049944,-0.08597812,-0.026692566,-0.021772064,-0.03306663,0.007258152,0.008227408,0.08731904,0.02109907,0.06001112,-0.01740704,-0.015672524,0.07099318,0.0005560753,0.013266237,0.045892127,0.0535156,-0.020427015,0.047887586,0.022979662,-0.03735193,-0.061848864,-0.05232066,-0.023192737,0.013666625,0.03376244,0.015774004,0.0099571245,-0.014292732,0.042208243,0.0037399693,0.03377743,0.040264122,0.033677068,-0.0071065216,0.0571545,-0.064792156,0.006971385,-0.07887191,-0.016733686,0.07467027,0.020505583,-0.023639986,0.027712079,-0.04598579,-0.025412373,0.023444697,0.07140278,-0.0310894,-0.042927112,-0.010277556,-0.09563425,-0.0015139258,0.015658781,0.045245357,0.10717618,0.03503158,0.13565579,0.017743867,0.04543672,0.023585929,-0.00591355,0.058422934,0.104426324,-0.010559069,0.025850298,-0.026971595,-0.040124413,0.04033423,0.040770184,-0.024777748,0.035127245,-0.019648103,-0.047810555,-0.013008946,-0.010605058,-0.049083974,0.117891334,0.09553916,0.005791825,-0.021215292,0.029304167,-0.02458315,0.044413395,0.042129256,-3.4744875e-08,-0.022152264,-0.09788636,-0.0009057968,0.019148765,0.027024198,0.017306024,0.034364782,0.0014706976,0.056391474,-0.016358813,-0.024931319,0.09781376,-0.024022307,-0.011908555,-0.0025907399,-0.024205398,0.036800675,0.066234104,0.046804998,0.018076384,-0.032791197,0.04352747,-0.13709463,0.013206112,0.0057704966,-0.041053224,-0.05208891,-0.017170224,0.09310893,0.008811484,0.035355628,0.018323848,-0.018511176,-0.034707025,-0.048160214,-0.03568466,-0.04205485,-0.05635819,-0.04895197,-0.0027408968,-0.037774526,0.024963077,-0.03185198,0.006986869,0.0052572275,-0.027690597,0.068733655,0.029613554,0.019581836,-0.005671663,-0.023043135,-0.0065689986,0.050263077,-0.12395066,-0.09423891,-0.05656063,0.08988673,-0.027155312,-0.039924096,-0.09224103,-0.07471055,0.012838111,0.18971857,0.0080251545 +1.21.4.5,"The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, converts tetrachlorohydroquinone to 2,6-dichlorohydroquinone in two steps, via 2,3,6-trichlorohydroquinone, using glutathione as the reducing agent. The enzyme is sensitive to oxidation - when an internal L-cysteine residue is oxidized, the enzyme produces 2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone and 2,6-dichloro-3-(glutathion-S-yl)-hydroquinone instead of its normal products.",384,0.99999994,-0.04441326,0.005510299,-0.075568765,-0.052905794,0.08192645,0.026505444,-0.036573954,0.09586189,0.0028560245,-0.021822758,0.034827024,-0.04454464,-0.0090506105,0.008366102,-0.05827979,0.08125097,-0.08282161,-0.013105443,-0.04937382,-0.059852317,-0.028190143,-0.017533483,-0.058907337,0.05734367,0.027126588,0.01573822,-0.0025677935,-0.021297168,-0.06852496,0.037359416,0.024310455,0.02211734,0.015776427,-0.053368885,-0.0038758984,0.091321334,-0.03090732,-0.043845087,0.0734848,0.05215359,-0.027291127,0.0021022742,-0.054037288,-0.014823205,0.014448826,0.07496644,0.012682567,0.09074448,0.051659286,0.02987505,0.012806954,-0.020791762,-0.050879646,0.09237074,0.0018342602,0.050627433,-0.03533969,0.013231577,-0.05497428,0.045621872,0.0028470256,0.021072997,0.019280748,0.05218447,-0.008659743,-0.0145494845,-0.026653856,-0.13666008,-0.031636234,-0.0766091,-0.048399076,-0.04272619,0.028151842,-0.026719477,-0.025334125,0.04737437,-0.017704548,-0.05084351,0.047657292,-0.06830711,0.019992316,-0.046933766,0.004278549,0.11007039,0.0376977,-0.050564863,0.013318915,-0.08377264,0.062926374,0.055398103,0.055699933,0.0111345,-0.039209347,-0.059242863,-0.14377545,0.06069875,-0.027139008,0.006445139,0.015693996,-0.019210147,-0.043832835,0.004259146,-0.041114494,-0.14735737,-0.07422522,0.01784017,-0.019770525,0.0706393,0.020273246,-0.019816104,-0.010337161,0.04356459,0.037466243,-0.026021596,-0.0251194,0.116469234,0.08607617,-0.013581917,-0.1232826,0.04511748,0.008335186,-0.004753195,0.07336145,0.018928653,-0.08744712,0.05129867,0.009422697,3.5369607e-33,0.053082537,0.041401442,0.023172164,-0.024172226,-0.008860871,0.007700654,-0.07722235,0.02522377,-0.04188306,-0.0619254,0.0039553028,-0.02610205,0.010365692,-0.01844193,0.03702387,0.0379843,-0.013234533,-0.031698853,0.019305425,0.048900228,0.004696093,0.05752467,-0.066397555,-0.005541739,0.044247244,0.13338886,-0.014657647,0.012133348,-0.019807396,0.030076323,-0.01679616,-0.038919423,-0.07936717,-0.023308458,0.020706832,-0.019741032,-0.07947969,-0.0074229673,0.0084981825,0.023801958,-0.017433334,0.012609874,-0.019770656,-0.0011012508,0.05238828,0.0046615154,-0.0004491323,0.058776304,0.038901523,0.06555278,-0.007059018,-0.014031379,0.061772782,0.022996996,-0.040302128,-0.03348248,0.054771766,-0.05112253,0.05046934,0.030379128,-0.006961534,0.14635748,-0.022556601,0.0138680255,-0.01470698,-0.076940686,-0.014428133,-0.015287834,-0.081607044,0.026146038,-0.047814507,0.024521874,0.0011386803,0.030486064,0.002901912,-0.038729608,0.014155487,-0.056149065,0.019340128,-0.05863444,-0.042234726,0.011221853,0.11628801,-0.049638726,-0.048024587,0.009305378,-0.027068157,0.016576886,-0.054008912,-0.018960122,0.110678665,-0.038168088,-0.053003136,-0.051834878,-0.016644252,-3.515787e-33,0.051697593,-0.116133206,-0.022486238,-0.084468335,-0.009171432,0.022591,-0.014294418,-0.020366825,0.06654364,0.020479769,0.044711795,-0.026264595,-0.06381241,-0.0013752349,0.03056522,-0.0775275,0.02593705,0.09574123,-0.03160893,-0.04579908,0.08074053,0.04825868,0.013935684,-0.005132454,0.031825036,0.03269077,-0.06102104,0.04991849,0.09327895,0.065503836,-0.08124833,-0.03192182,0.007637044,0.0071901637,0.07546835,0.03194678,-0.06787829,0.016423386,0.06032601,0.049509127,0.0072897994,-0.015584956,-0.028099375,0.0046374896,0.01238137,0.110310435,-0.14194274,0.0030411626,-0.02101277,0.00357894,0.08193853,-0.0026406392,-0.021103976,0.016356003,0.036879104,0.017259516,-0.017098254,-0.08294457,-0.04477495,-0.024153618,-0.019621015,-0.0737223,-0.027903173,0.011070521,-0.038084812,0.11699592,0.04481648,0.07015188,0.016565125,-0.04528262,0.039625123,0.0070299683,0.03379016,0.050115243,-0.037845936,-0.05520373,-0.04329131,0.01351642,0.05091724,0.003322057,0.0012309661,-0.0016356204,0.045136854,0.0011883514,0.0059048007,-0.060755793,-0.055443674,0.07953057,-0.016385995,0.03752562,-0.03413634,0.09634207,0.0049341065,0.022767901,0.11564334,-4.303107e-08,0.00520662,-0.12915763,0.07462243,-0.021553693,0.07298999,0.021296952,0.0011298866,0.025737181,0.07593518,-0.061795138,0.046860185,0.108229786,0.021997062,-0.0043525365,0.031242069,0.03126934,0.031416763,-0.039091606,0.0055011148,0.030413251,-0.047254756,-0.0147879,-0.09900923,-0.05835262,0.009231692,-0.052382693,0.03524439,0.0184771,-0.04673548,-0.011377678,-0.009524225,-0.027768103,-0.07988178,-0.004360655,-0.08065604,0.045217577,-0.06347693,-0.013908169,-0.01761316,0.010384053,-0.05704244,0.0353703,-0.08395924,0.06369335,0.056128416,-0.047884163,0.050961055,-0.023844885,0.015151929,0.026953923,0.0074799117,-0.030673614,0.06831521,-0.044066247,-0.11328444,0.01637504,0.032484837,-0.0734951,-0.0987945,-0.09442815,-0.012255676,0.019265324,0.17062253,0.060548097 +2.1.1.351,"The enzyme, isolated from the bacterium Saccharothrix syringae, is involved in the biosynthesis of nocamycin I and nocamycin II.",384,1.0,-0.0060969954,-0.015826276,-0.12215934,-0.04025364,0.036194727,-0.033944555,-0.032874268,0.04922084,0.12893921,-0.022424737,0.062266298,-0.0007925198,0.026167944,0.07193145,-0.014907462,-0.00012628784,-0.07162866,-0.036306113,0.01672474,-0.0156156635,0.0764435,0.060388543,0.019602422,-0.023541762,0.064372495,-0.02515387,0.00024332645,0.04558816,-0.010977931,-0.0644199,0.04248317,-0.03846151,-0.00047049453,-0.040462036,0.12138603,0.0070708855,-0.025324943,-0.033936262,0.08292061,0.032448158,-0.017182982,-0.04216892,-0.050911702,-0.0038796174,-0.02827067,0.060482252,0.029005537,0.037100956,0.025624163,-0.020240052,-0.07087676,-0.039373007,-0.005451053,0.0063744406,0.07093937,0.04155496,-0.057784244,-0.03144794,-0.027269397,-0.0055779386,0.057571013,0.00048134328,0.023846539,0.022389462,-0.08031249,-0.022329863,0.020013452,-0.047348846,0.057419673,-0.040816974,-0.12948926,-0.05202535,-0.02280348,0.074390374,0.002176157,-0.026910612,-0.027965225,0.016576212,-0.028943729,-0.04385131,0.05080749,-0.012744996,-0.051012073,0.102568135,-0.026543885,-0.0031213185,0.12894262,0.05315721,0.10056202,0.014556709,-0.0062571936,-0.027551332,-0.019246835,-0.07105593,-0.03224882,-0.017123103,-4.3487413e-05,0.043022495,-0.012237299,-0.031003188,0.012657217,-0.012912095,0.01465477,-0.09319485,0.010845191,0.05407783,-0.05360062,-0.010761698,0.026270425,-0.037937816,-0.022062268,0.05444065,0.018720651,-0.037298348,-0.009158709,0.104693815,0.08085767,-0.0852461,-0.10536393,0.011031435,0.05490561,-0.03273804,-0.0015777954,0.0948984,-0.023814522,0.10478926,-0.08262926,4.372859e-34,0.0036861075,0.06567344,-0.011911552,-0.04029348,0.061784983,-0.05252449,-0.036899243,0.008354742,-0.07303869,-0.022923563,-0.070736416,-0.14768009,-0.016841501,-0.02216508,-0.0020476484,0.018076094,0.014704022,-0.04036986,0.036109947,0.007608496,0.00949756,0.06848674,-0.026094267,0.046734568,0.019460171,0.06593009,0.036425676,-0.03768721,0.11037965,-0.055056874,0.061415575,-0.085746616,-0.020332428,-0.0025465381,0.15006198,-0.027308289,-0.011670366,-0.019300614,0.053804114,0.0645934,0.0017423155,0.074091256,0.010712662,-0.035531886,0.074908026,-0.023332028,-0.06827312,0.091494344,0.057732813,0.022905659,0.049903844,0.024367176,0.059162803,-0.017910777,-0.061043695,0.013207751,-3.1153453e-05,0.013334545,-0.037323125,-0.025631502,-0.08940258,-0.02841148,-0.039499074,-0.019416595,-0.01474432,0.05006793,-0.0605281,-0.005545421,-0.015428364,0.024949225,-0.08122095,-0.007637326,-0.0043468866,-0.004390117,0.057890832,0.052118078,-0.12664694,-0.011974735,0.053649846,-0.004366328,-0.0664658,0.07260192,-0.031733435,-0.02664423,-0.025511509,-0.012649442,-0.02993461,-0.058265306,-0.04291018,0.025522135,0.003764787,-0.041011233,-0.0928088,-0.031503715,0.00024450177,-1.9267767e-33,0.060897157,-0.022832982,0.0481407,-0.047610324,0.011164416,0.06977459,-0.027106216,0.0042775674,0.040314928,-0.0062035243,0.0013746459,-0.050829705,-0.011883033,-0.037811287,0.05190552,0.029351968,0.008892199,0.13442515,-0.079363964,0.04043809,0.03412746,0.08816909,0.009498384,-0.044888455,0.056211863,0.060308833,0.032901153,0.11568267,0.093782924,-0.002727727,0.034987114,-0.037834,-0.020626795,-0.11131776,-0.023038065,0.06323189,-0.005536264,0.010158334,0.012889007,-0.032631863,-0.012018279,0.022439964,0.026721504,0.063286334,-0.0150345275,-0.0016675043,-0.09076888,0.046405938,-0.03745029,-0.09283344,-0.004458506,-0.037272837,0.03302884,0.029609807,0.023529705,0.051911198,0.057813864,0.051813588,0.010413475,-0.1007701,-0.024976553,-0.04748636,0.016862253,-0.021481985,0.052425835,0.044287514,-0.014825452,-0.009745854,0.016833581,-0.064598836,0.03766412,0.022884933,-0.05344287,0.0017778592,0.009693029,0.0449429,-0.0863592,-0.05324067,0.0034304436,-0.0002754014,-0.08259593,-0.015014038,0.0072436417,-0.023727538,-0.015358886,-0.0022465675,0.089194365,0.027772268,0.04626471,0.025769658,-0.031185577,0.043372475,-0.06216326,0.062818125,0.007174122,-2.5197568e-08,0.027018096,-0.10310471,-0.008668043,-0.020159656,0.02397562,-0.01796983,-0.005177301,0.04633519,-0.0012740813,0.019982455,0.05094517,0.07565963,0.0073264777,-0.025105568,0.036494777,0.04761459,-0.037603706,-0.049293555,-0.025878217,-0.024604386,-0.050244153,-0.02200528,-0.14766532,0.048468247,0.03573149,-0.08057628,-0.015005604,-0.043078944,-0.015339088,-0.008177522,0.016378567,0.031304117,-0.002120826,-0.073375605,-0.104029715,-0.010236786,-0.062587254,-0.0128920395,0.069443196,0.011387343,0.05956795,-0.025281796,-0.03626215,0.058108438,-0.04207259,0.036492992,-0.007106614,-0.035990562,-0.018244488,0.034410957,0.02413281,0.023837257,-0.028446855,-0.00033562043,-0.1509185,-8.826948e-05,0.028628208,-0.068475425,0.013674773,-0.05273458,-0.024800776,-0.010395813,0.22360459,-0.02629952 +2.1.1.352,"This activity is part of the noscapine biosynthesis pathway, as characterized in the plant Papaver somniferum (opium poppy). It is catalysed by heterodimeric complexes of the OMT2 gene product and the product of either OMT3 or 6OMT. OMT2 is the catalytic subunit in both complexes.",384,1.0,0.008726295,0.017935064,-0.090847224,0.0063616284,0.13105556,0.031879313,-0.057930328,0.025312528,0.09854157,-0.06727223,0.01839207,0.010077257,-0.06799836,-0.056959808,-0.024026092,0.023030618,-0.16180381,0.054438245,0.036063537,-0.04468262,0.07579389,0.055138547,0.06258614,-0.04553329,-0.031069947,0.065677404,-0.018349545,-0.013182685,0.059993144,-0.10579762,0.06307586,0.015473804,-0.006330737,-0.0326968,-0.06548151,0.024527894,-0.03552801,-0.060044684,0.055273257,-0.022276795,0.11465511,-0.05107498,-0.02127845,-0.0026570838,-0.0147422515,0.037275765,-0.007047657,-0.03682548,-0.01735861,-0.06830939,-0.040005848,-0.06577877,0.023049936,-0.005356965,0.022153039,0.03866725,-0.013569721,-0.029644575,0.038876355,0.024243597,0.034811657,0.025779746,-0.015600872,-0.020115374,0.12315622,-0.042381987,0.019556364,0.011330689,0.033119842,-0.056406487,-0.061402783,-0.019784434,-0.01738597,0.03955153,-0.040036082,0.10381926,-0.08759089,0.0458614,-0.0004892976,0.0580863,0.061937474,0.06479831,0.038832124,0.11858867,0.01305349,-0.013867736,-0.067908116,0.08115555,0.034695916,0.032230612,-0.012809457,-0.023627717,-0.06822231,0.06322364,-0.07939534,-0.002660481,0.09346165,0.012171644,-0.031655543,-0.016015613,-0.014601483,0.05321274,-0.07437713,-0.06981913,0.0051675127,0.005107141,-0.00514141,0.0203722,0.013512233,0.012848836,-0.028655415,-0.0631223,-0.019850079,-0.0051574237,-0.09184518,0.080853716,0.01883698,-0.058541596,-0.016514385,-0.067309536,-0.04045538,0.0029829713,0.010543138,0.043902434,-0.04729232,0.0071067316,-0.12992781,2.7161588e-33,-0.010425575,0.043480575,-0.027735142,-0.022540694,0.0034989845,-0.048612673,-0.01523983,-0.029221773,0.007994111,-0.012737731,-0.04902089,-0.09936289,-0.052031733,0.026534444,0.021443957,-0.09531919,-0.010511422,-0.010344244,0.0632824,-0.10580027,-0.02290829,0.079528525,-0.08297506,0.020827042,0.053399496,0.0931406,-0.03476255,-0.060072407,0.09428491,-0.010200903,0.039795652,0.0041635646,-0.027117582,0.006737963,0.034906,0.006750796,-0.030268524,-0.070707954,-0.027512314,0.05961509,-0.018496295,-0.0019439469,0.06483214,-0.023884283,-0.007812109,-0.02290828,-0.03950112,0.10234886,0.061794646,0.04966415,0.0044751274,-0.040331446,-0.036424,0.030218642,-0.0596436,0.021207599,-0.054668393,-0.023805685,0.03103036,0.05230515,-0.0082725175,-0.042724784,-0.032058053,0.05307153,0.040972013,0.07331438,-0.08832992,-0.0043873866,0.016119473,0.14548919,0.009066125,-0.032806937,0.020760082,0.05739018,0.020714866,0.044882078,-0.011891614,0.055086598,0.04908976,0.02442724,0.056034103,-0.020859564,-0.03603122,-0.02368419,-0.009319534,-0.0059322757,-0.027075123,-0.038908776,-0.030389769,0.09237437,-0.020463701,-0.039657753,-0.067340605,-0.010590681,-0.02715335,-3.9125103e-33,0.080913536,-0.057066184,0.050589934,-0.05453134,-0.035586417,0.09075306,-0.075537965,-0.019695323,-0.006579788,0.068792835,-0.010888083,-0.014279047,0.074780166,-0.049686223,-0.033983443,-0.054706097,0.034000404,0.07666635,-0.041766327,0.03529376,-0.045933295,0.059600424,-0.040334508,0.043037046,0.01841223,0.013417862,0.085190736,0.028966265,-0.015241064,0.06396959,0.031258043,-0.002545811,-0.058181524,-0.008187521,-0.025424432,0.07799543,0.034186646,0.0081334505,-0.0075874473,-0.014643251,-0.025622072,-0.06935818,0.030788984,0.04292824,0.032104276,-0.023803966,-0.08900726,0.046723716,0.048268292,-0.013351679,0.037692927,0.04078036,0.0183037,0.02072191,-0.02295146,0.0008310856,0.052458055,-0.1255109,-0.045313116,-0.12996906,0.037504982,-0.0031482484,-0.06318349,-0.03487405,0.04689504,-0.038697533,-0.06399468,0.03646572,0.014173465,0.032083362,0.022800088,-0.020093422,0.04590528,0.013594669,-0.029553276,-0.01487992,-0.0754931,-0.0064598215,0.04091391,-0.04023549,-0.022147708,0.0050736507,0.057860088,-0.062211547,-0.0164909,0.016011005,0.057707727,0.165486,0.01724165,0.020981336,-0.00035951313,0.024224587,-0.09418161,0.08608534,0.02624841,-3.4609346e-08,-0.014278521,-0.11739758,0.025172118,0.021095898,-0.081356615,0.038625054,-0.031805497,0.0019932673,-0.013748519,0.015789507,-0.012939597,0.10649416,-0.052521937,-0.020640453,0.010528853,-0.032068465,0.005636788,0.03147019,-0.03473512,-0.04750675,-0.13104355,-0.0066207377,0.008475864,0.0038032634,0.0313299,-0.05693298,0.02772293,0.053190038,0.02445287,-0.030055966,0.039747473,-0.0011374891,-0.056875385,-0.025406146,-0.05534217,0.050173,0.084103376,-0.12407077,0.025249025,-0.04004322,0.02498546,-0.030044086,-0.041431434,0.030520052,-0.05238693,0.053385567,0.020631043,0.022132525,-0.01514908,-0.007849615,-0.022314103,0.0062597473,0.00342524,0.0011584382,-0.07351044,0.001742326,-0.025578251,0.015329596,0.03273652,-0.03708971,0.05606493,-0.004615886,0.20403188,0.02373216 +2.3.1.278,"The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA---trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3.",384,1.0,-0.027482847,-0.070632085,-0.1257137,-0.01981262,-0.02055944,0.017988827,-0.017104596,0.06404838,0.034651637,9.376482e-05,-0.022723218,0.03496394,-0.006505332,0.028845385,-0.07048563,0.02341131,-0.05880278,-0.014528683,0.0114360945,-0.05406174,0.072655484,0.059108615,0.005448271,-0.07996306,0.053269606,-0.027467577,-0.0018587393,-0.030466534,0.0061536883,-0.086264506,-0.010345661,0.0029246265,0.0013681834,-0.033223562,0.093427256,0.102318496,-0.045975123,-0.0100640515,0.1407727,0.018053427,0.053027473,-0.08852406,-0.006457145,-0.005101486,0.003948691,0.031229151,-0.017942104,0.083514854,0.0018697451,0.02187144,-0.05709211,-0.026168678,-0.050768737,0.01699986,0.029562542,0.033987086,0.015178803,-0.027195903,0.040736634,0.016393825,0.07647758,-0.008231946,0.0076664914,0.06398478,-0.026054472,-0.044654272,0.013302497,-0.06204626,0.05818151,-0.033725724,-0.10762325,-0.0058573796,-0.04333916,0.06449313,-0.007353133,-0.0414516,-0.027327837,-0.02486641,0.0050193453,0.040027205,0.016159743,-0.014786156,0.042046,0.0756388,0.047000207,-0.062794395,0.10692618,0.028574346,0.046648666,0.06724194,0.014240808,-0.017350998,0.047066055,-0.021743542,-0.11784593,0.0062805414,0.07492136,-0.04345408,-0.014903906,-0.02876841,0.0047261002,-0.0030279336,0.029477173,-0.03336092,-0.046105828,0.023710795,-0.0907288,0.053427495,0.043577794,-0.0077759367,-0.0480477,0.08211173,0.045635637,-0.0071586305,-0.030639226,0.042749297,0.034299683,-0.0670967,0.011914085,-0.0013264235,0.021203756,-0.024512827,0.011282321,0.04319852,-0.047976263,0.080948226,-0.040841196,1.2032735e-33,0.056423135,0.043049987,0.012747605,-0.051286902,0.053593304,-0.065238714,-0.0591525,0.0028934516,-0.100375205,-0.013620898,-0.011609512,-0.10446367,0.0008308531,0.14348783,-0.010933597,0.069784515,-0.016310351,0.016224148,0.060456544,0.03761383,-0.0066272155,0.06633373,0.012115182,0.030704908,0.04679411,0.067550495,0.003628049,0.047133967,0.022014184,0.0019632787,0.044544052,-0.08073248,-0.083007015,-0.010341534,0.08518537,-0.008337472,-0.0018393006,-0.07109773,0.011387065,0.064266555,0.008028128,0.030206084,0.030369354,-0.05758781,0.07668717,-0.024060363,-0.06230164,0.032532394,-0.016254017,0.069091514,0.04688693,-0.012166792,0.04893675,0.061345443,-0.03317751,-0.028394215,-0.024707817,0.02490459,0.026199171,-0.028275054,0.0557206,0.015701413,-0.050527785,0.025651295,-0.043024827,0.010461879,-0.04340912,0.0032013678,0.0035990286,0.012606828,-0.024875714,-0.028728507,-0.0057329233,-0.006910204,0.10322457,-0.02055982,-0.08353838,-0.039258044,-0.02232259,-0.051380552,-0.02368934,0.014452576,-0.01627597,-0.079092205,-0.0610417,-0.04424315,-0.029439347,-0.09311747,-0.030703194,-0.052045647,-0.010826129,-0.04542628,-0.06296187,0.069027774,-0.02420914,-2.6809191e-33,0.117711656,-0.11833653,0.06906713,-0.085124135,-0.049917642,-0.054381263,-0.0139845265,-0.025169123,0.03641288,-0.009613778,0.015535724,-0.0071322387,0.025419036,-0.0056992024,-0.024119485,-0.026207184,0.03854845,0.055418108,-0.074069366,-0.02659288,0.0066156965,0.07893897,0.040682137,-0.008397198,0.012960424,0.027707884,-0.033867925,0.022518683,0.035362545,0.07384904,-0.0013935597,0.018384231,0.013158534,-0.047787465,-0.119093455,0.018329645,-0.105379246,-0.03674854,0.07079015,0.017437773,0.029215846,0.048001643,0.022790518,-0.0043028076,0.06924434,0.010952121,-0.07900234,-0.001887649,0.009662118,-0.09012977,-0.010371543,0.06897165,0.05439081,0.012022051,0.04800679,0.032195084,0.049038175,-0.023256592,0.0021429935,-0.08883588,-0.038734395,-0.029329276,0.033869185,-0.015675273,0.1248744,0.12145651,-0.009567467,0.08637498,0.070149325,-0.0271619,0.037168138,0.0025474625,-0.016992949,0.057246298,0.03563116,-0.038494486,-0.08097641,0.017689738,-0.021912975,0.03671899,-0.06531146,-0.022389868,0.021224564,-0.087685205,-0.06176519,-0.11367041,0.02149569,0.117201954,-0.02050709,0.056711826,-0.03356842,0.011392734,-0.07481942,0.012046893,0.10727484,-4.2014314e-08,0.025108403,-0.02409628,0.020327874,-0.047849353,0.011745586,0.018283397,-0.011369981,0.02208755,0.065489724,-0.04979018,-0.037326366,0.06959151,0.041805703,-0.014208091,0.025098743,0.07998542,-0.041298352,-0.07547365,-0.029244924,-0.045116734,-0.08082072,-0.013300654,-0.07895308,0.09679997,-0.011764975,-0.027019378,0.0024162433,0.03296179,-0.038643647,0.04655306,-0.054576535,0.083378606,-0.015663521,-0.047599386,-0.0818428,0.045123737,-0.008212113,-0.08355013,0.047709424,0.03118458,0.06504955,-0.02806062,-0.07577296,0.034426935,-0.009262511,0.017813843,0.0069111884,-0.005505441,-0.04646878,-0.03825669,0.058435187,0.0007665047,-0.06470101,-0.010398358,-0.081983894,0.06738873,-0.07258131,-0.047449946,-0.03181619,-0.047489822,0.02982933,0.03405408,0.1905526,-0.08954223 +2.3.1.279,"The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase).",384,1.0,-0.022148175,-0.06307977,-0.12175918,-0.02639948,-0.014447271,0.0039488715,-0.008389187,0.0714938,0.025566887,0.002689393,-0.034896526,0.02475221,-0.009150175,0.023634572,-0.07003825,0.018929588,-0.047301292,-0.016234558,0.030033126,-0.0503234,0.064870216,0.0731866,0.010956416,-0.08217276,0.047766708,-0.013477631,-0.0038965319,-0.018921053,0.007865271,-0.072993815,-0.0021719611,0.00019953938,0.014965408,-0.041311797,0.09071695,0.1017253,-0.049628284,-0.0043078177,0.1333483,0.01786439,0.051883567,-0.104508124,-0.0016571004,-0.004550616,0.018398177,0.033340655,-0.026963284,0.09631035,-0.006208835,0.022893714,-0.06120713,-0.03106819,-0.05027881,0.022022069,0.03611486,0.020632405,0.017276483,-0.023733165,0.026822545,0.022425532,0.081110634,-0.010309497,0.010087935,0.06634372,-0.005101657,-0.038292743,0.0031652015,-0.06250836,0.055911396,-0.029512925,-0.10397327,0.00050949893,-0.043687794,0.071068056,-0.017371414,-0.04220302,-0.02995328,-0.0029361057,0.0076105897,0.03324134,0.022019586,-0.012062635,0.040700387,0.07506916,0.03995752,-0.063079484,0.101406,0.033519495,0.04877856,0.07071407,0.009064589,-0.027653242,0.038554978,-0.008762573,-0.13246064,0.0027111298,0.06599439,-0.04180851,-0.012284815,-0.028938022,-0.006889882,-0.0063963584,0.01580244,-0.037112795,-0.05787829,0.035362266,-0.098802105,0.043655045,0.04555204,0.0027129066,-0.042300362,0.07169757,0.047437478,-0.0042632893,-0.020527119,0.036262322,0.037365142,-0.07105456,0.011110522,0.0013528662,0.0076501733,-0.022351354,0.0055466075,0.035898555,-0.055479523,0.08213785,-0.054108683,1.1272366e-33,0.04967459,0.03512856,0.007677001,-0.045741297,0.056559853,-0.06614697,-0.060433514,0.0024986207,-0.10148159,-0.014062128,-0.006287727,-0.09905824,0.01100376,0.13814914,-0.018461775,0.0764368,-0.016271276,0.024155898,0.073161386,0.03438634,-0.0073554274,0.06636918,0.009324538,0.01995384,0.04541374,0.07308763,-0.010867033,0.033617634,0.030197933,-0.0007922858,0.03001173,-0.07795519,-0.07558993,-0.01954268,0.095116384,-0.0243062,0.006931293,-0.08391034,-0.0040714215,0.05883849,-0.0003627279,0.019300492,0.031131584,-0.0570657,0.067622826,-0.03216302,-0.05918345,0.024758413,-0.0073332284,0.061732005,0.054642517,-0.0118187675,0.056455642,0.05434427,-0.03577963,-0.03264447,-0.011973967,0.026925972,0.015047008,-0.024224732,0.03982183,0.013729662,-0.05198154,0.023827592,-0.043615557,0.00035861557,-0.046940915,0.0060877563,0.0059937104,0.019733952,-0.018864548,-0.02419311,0.006528869,-0.022366356,0.115493864,-0.019304847,-0.07860575,-0.030377626,-0.034601223,-0.04195012,-0.017534731,0.008617415,-0.023163153,-0.09015883,-0.059932705,-0.027522199,-0.021280691,-0.098770045,-0.026539272,-0.055155102,-0.036770977,-0.0537172,-0.06916335,0.068844475,-0.02492305,-2.8522197e-33,0.11112052,-0.10955316,0.06263414,-0.08029479,-0.04476178,-0.052871633,-0.013861622,-0.02113853,0.042677656,-0.0073685707,0.011248309,-0.019994542,0.023398712,-0.0019952874,-0.029711394,-0.019172788,0.03413164,0.053652793,-0.068116054,-0.038966846,0.016322663,0.09614584,0.0319531,0.00830416,0.007823295,0.030264506,-0.02460742,0.03336388,0.033842705,0.08148338,0.0049414188,0.0036004751,0.013758218,-0.06062912,-0.11443025,0.024752641,-0.114985816,-0.03848355,0.07111438,0.0093437405,0.023097364,0.050721608,0.029799066,-0.006858185,0.060658045,0.013428574,-0.083635084,0.01479464,0.007999876,-0.086865105,-0.010325779,0.06803723,0.043257806,0.024249284,0.04648572,0.026725117,0.045795325,-0.009093495,-0.00039847413,-0.08820119,-0.03530382,-0.035645757,0.028135726,-0.013564377,0.129235,0.12955649,-0.015575254,0.06887945,0.07744245,-0.023748163,0.025614172,0.0066605867,-0.009146515,0.06440938,0.039791144,-0.030572506,-0.06588554,0.0148286875,-0.015599256,0.038778987,-0.06431865,-0.03258824,0.034546353,-0.094364636,-0.064101405,-0.11031589,0.014611663,0.11685677,-0.019119931,0.0532928,-0.021905348,0.026055602,-0.09111304,0.0016103465,0.10062551,-4.198434e-08,0.039368603,-0.03926518,0.008958277,-0.045794994,0.005132404,0.006926289,-0.0072013102,0.013532328,0.07414864,-0.051532183,-0.025212372,0.06422036,0.03242314,-0.013571568,0.036034722,0.06875492,-0.03585398,-0.076444425,-0.04030489,-0.05561044,-0.07747564,-0.020490848,-0.06591234,0.09335594,-0.005742433,-0.038334146,-0.0014609778,0.02884232,-0.029249936,0.053941023,-0.047764104,0.08282182,-0.012836434,-0.047351647,-0.07664506,0.05893974,-0.0129384,-0.083471395,0.055319015,0.037617236,0.066414766,-0.03175734,-0.07689132,0.034636524,-0.02005231,0.02492124,0.0041759447,0.006239613,-0.03944693,-0.040169388,0.049216744,0.011493045,-0.06497304,-0.0074904994,-0.08542565,0.06385058,-0.07444408,-0.040413268,-0.020954793,-0.045321554,0.03184148,0.032913253,0.2042949,-0.08142663 +2.3.1.280,"The enzyme, characterized from the bacterium Escherichia coli, is able to acetylate a range of (aminoalkyl)phosphonic acids. Requires a divalent metal ion for activity.",384,1.0,-0.05862076,-0.09414209,-0.08532904,-0.025687052,-0.009206146,0.084666684,0.0031619219,0.03001229,-0.005225936,-0.023650426,0.02098708,-0.053429358,-0.052452955,0.06495501,-0.03359159,-0.020600049,-0.010522075,0.04508234,-0.048497193,-0.057256956,0.07333195,0.083128564,-0.06714592,-0.027150251,0.027916046,0.047656868,0.019890627,-0.041323427,-0.029465955,-0.017689286,0.009307555,-0.031959083,0.11534641,-0.05779625,0.066533014,0.05212821,-0.07449891,-0.09375425,0.061764702,-0.02729195,0.027934,0.07402068,0.04854254,-0.03986203,-0.044031013,-0.087951936,0.00554229,-0.049260844,0.023995742,-0.010035008,-0.07141454,-0.044192445,0.012686487,0.038628723,-0.065037794,0.03588207,-0.032925177,-0.017899668,0.0044811387,-0.024833107,0.042716563,0.0059837806,0.033000834,0.044151332,0.017601816,-0.067598306,0.04934448,-0.074008696,-0.002326359,-0.00020991618,-0.041634806,-0.034391437,-0.025861958,0.06905997,0.078762874,-0.027336748,0.054525103,-0.0586065,0.06848882,0.016564153,0.043927033,-0.050773725,-0.039664645,0.01091139,0.025038509,0.07260751,0.015556729,-0.030491678,0.02643102,0.044142973,0.0017519973,-0.038930424,0.02855022,-0.13518241,-0.026407087,0.0022743738,-0.005418831,-0.016262384,0.066952124,0.015851684,0.015874278,0.11278535,-0.0027769832,-0.059890375,-0.059240796,-0.025432887,-0.025946477,0.09535574,-0.03160043,0.013675488,-0.0006306115,-0.020239068,0.07605536,-0.05294995,0.041959487,0.051928494,-0.012084884,-0.11412581,-0.05124252,0.015547007,0.038854625,-0.07775475,-0.025171496,0.0854362,-0.004138855,0.04949063,-0.054070417,-9.204403e-34,0.04789305,0.021108354,0.06781124,-0.09571223,0.060432225,-0.09262966,-0.07617039,-0.0017484955,-0.0057952157,-0.026536224,-0.049080115,0.02305857,0.065179825,-0.015308204,0.042880982,0.043716576,-0.039647304,0.039738785,0.06467432,0.05051352,0.020355823,0.0007262276,0.023144415,0.043813676,0.06496343,0.016952083,-0.03564462,-0.03294317,0.02118347,-0.003168488,0.007592149,-0.040111385,-0.06666223,0.014254853,0.02422923,-0.025111293,-0.0066360403,-0.020370405,0.045818225,-0.02688283,0.019475138,0.07635705,-0.038791753,0.10562921,0.07778173,-0.04280908,-0.07212741,0.116578326,0.022518922,0.04994233,0.024338946,0.0004977103,0.049758095,-0.01684314,0.0061583784,0.05125487,-0.005450161,0.02380762,0.005174106,0.02204518,0.0066969395,0.05327796,-0.02777387,0.052578818,-0.007534693,0.034101244,-0.009443904,-0.05632993,0.08863485,0.039926663,-0.08775388,-0.06423571,0.012203938,0.0370155,-0.045481287,-0.04276921,-0.045629453,-0.07622959,0.08625705,0.016880983,-0.031266626,-0.016737018,0.006274072,0.023086034,-0.06021038,-0.049653128,-0.024476778,-0.047503438,0.0007274831,-0.0056006657,0.041954976,-0.031330638,-0.03152496,0.004514857,0.01412322,-2.7867105e-33,0.110326596,-0.052033037,0.019792413,-0.054749195,-0.059459742,0.08549173,0.013646209,0.013938714,0.027289793,0.012334245,0.05651981,-0.008430396,0.060222607,-0.04745376,0.006318121,-0.014775689,-0.03719374,0.071671546,0.062427714,0.04646814,-0.014902183,0.042647965,0.08069752,0.019110845,0.039671827,-0.0045296606,-0.117164835,0.028627632,0.006124906,0.05488214,-0.013573158,-0.0411779,-0.01090883,-0.12265386,-0.028497025,0.09735883,0.0142047815,0.029498706,0.0033709921,0.009174217,-0.019537376,0.042210747,0.025794577,0.043597892,-0.0120313065,0.09101296,-0.045257606,0.05776886,-0.024809597,-0.096556865,0.062494732,-0.025462186,0.022114746,-0.054304667,0.016551062,0.073786214,-0.014069518,-0.03390219,-0.065681666,-0.011690599,-0.051232237,-0.088526085,0.0036637702,-0.046126083,0.0020537644,0.032235935,0.03062674,0.024665585,-0.015323387,-0.08757638,0.060912557,0.06648344,0.05949731,0.046636194,-0.03170602,-0.0314144,-0.11130093,-0.1269645,0.0008657254,-0.028872022,0.006325059,0.08976378,-0.008322652,-0.08382207,0.066723995,-0.04786852,0.024894567,0.015176552,-0.016839975,0.07049887,-0.03887172,-0.029996235,-0.030918198,0.0047486215,0.024487816,-3.3121232e-08,0.043902833,0.013339921,0.03614155,-0.1534293,0.003563055,0.023446273,0.016098475,-0.09308735,0.08251929,-0.04054268,0.0026462893,0.04073624,0.0148223955,0.07195966,0.02232446,0.031974904,-0.07977667,0.038058702,-0.056771424,-0.039053258,-0.038589872,0.01676634,-0.08872279,-0.0045437934,0.001948707,-0.035687048,0.025511917,0.05558647,-0.097679965,0.06276671,-0.07913518,0.014476403,-0.02768273,0.02010275,-0.09249565,0.0012496915,-0.049670227,-0.06538151,-0.09957356,-0.039636146,-0.030512594,0.017685708,-0.13878618,0.032746732,0.009403994,0.025411228,-0.0109134475,0.041504882,-0.015074328,0.006130998,0.024436519,-0.05159104,-0.0020002925,-0.07825946,-0.093367964,0.0054814103,0.002873079,-0.06743556,-0.047335353,-0.026415557,0.02445479,0.046889763,0.18599431,-0.038301975 +2.4.1.360,"The enzyme has been characterized in Oryza sativa (rice), various Citrus spp., Glycine max (soybean), and Fagopyrum esculentum (buckwheat). Flavanone substrates require a 2-hydroxy group. The meta-stable flavanone substrates such as 2-hydroxynaringenin exist in an equilibrium with open forms such as 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione, which are the actual substrates for the glucosyl-transfer reaction (see EC 1.14.14.162, flavanone 2-hydroxylase). The enzyme can also act on dihydrochalcones. The enzymes from citrus plants can catalyse a second C-glycosylation reaction at position 5.",384,1.0,-0.045020062,-0.13189091,-0.14516178,-0.013176533,0.07352485,0.07919101,-0.13343947,0.04190755,0.013045551,-0.05961802,0.058148067,0.028453097,-0.07059016,-0.017404458,-0.037152085,0.027295055,0.022149203,-0.00811538,-0.06622396,-0.05557531,0.062052283,-0.08169417,-0.009777767,-0.0489119,-0.008017466,-0.07370619,-0.014521405,-0.06927487,-0.0044623585,-0.06305733,-0.014351665,-0.03803789,-0.039292116,0.039792184,-0.020100258,0.029586367,0.01683759,-0.06759048,0.061699446,-0.003200183,0.020091688,-0.03637448,0.014557323,-0.075949565,0.010784579,-0.056437403,0.023418555,0.038457893,0.032956902,0.008497935,-0.05887284,-0.021694532,-0.039120797,0.020133583,0.043796595,0.013854491,-0.011115787,0.005459759,0.0023234948,0.077724524,0.045166295,0.017646724,-0.045627035,0.012313956,-0.10289949,-0.06431696,-0.021266302,-0.012455799,0.030288398,-0.017477974,-0.037684664,-0.0746503,0.010378638,0.016720403,0.053864412,0.06421906,-0.060221646,0.08912973,0.050983604,-0.028808707,0.06803517,-0.05117356,0.054653905,0.058886997,-0.06275465,-0.012964287,-0.075085215,0.06832304,0.050931446,0.03671231,0.025375344,0.015232908,-0.033809625,-0.031611066,-0.013648747,0.062484723,0.04274109,-0.07473581,0.028919414,-0.003810888,-0.050075594,0.019059284,0.047589123,-0.063500054,-0.08259992,0.014562902,-0.027260622,0.074256316,0.05132224,0.005577551,0.041943166,0.05874366,0.05386352,-0.015513556,-0.056646634,0.04573101,0.03774048,-0.03608486,-0.05727289,-0.0519512,0.04006653,0.062033795,0.049510468,0.048840158,-0.064487614,0.04742851,-0.019615188,3.771055e-33,0.11509121,0.06684013,0.01550735,-0.045260284,0.0205234,-0.035392303,-0.050089862,0.020030243,0.014454019,-0.038806256,-0.052401774,-0.024556926,-0.0327215,0.048437357,-0.00665316,-0.008439393,0.0032950123,-0.060669728,0.07447313,-0.061269186,0.06622589,0.02579618,-0.047916856,0.00090937474,0.009115675,0.059367634,0.02680928,0.041333042,0.00073549186,0.006606216,-0.023608556,-0.08717744,-0.050132565,0.05556392,0.051271014,-0.004840457,-0.09399751,-0.051708836,0.04269444,0.06223364,0.022606213,-0.0017183523,0.023213984,-0.00252177,0.02853136,-0.01675343,-0.048704643,0.067503154,-0.0009889172,0.066128165,-0.03374397,-0.014875573,0.07787442,0.06281021,-0.03877209,0.037519034,0.027270166,-0.0055189547,0.035349756,0.035457116,-0.05855435,0.057103828,0.020314002,-0.0059551643,-0.07916244,0.0011093434,-0.12679169,0.0071785483,-0.034503747,0.05037201,0.028109355,-0.05150425,0.07619075,-0.014806168,0.08672393,-0.08618219,0.029854227,0.008637452,0.022003254,-0.014952168,-0.042882435,0.026701113,0.02240405,0.05991969,-0.115405664,0.002888052,-0.09820738,-0.040033326,0.00064395834,0.052539375,-0.008613897,-0.021316154,0.039718173,0.055510387,-0.0016277973,-3.8664717e-33,0.102240935,-0.08176368,0.064725325,-0.03583265,0.007753656,-0.023074847,0.028338132,-0.03628551,-0.019192494,-0.075719744,0.0007367244,0.012407999,0.012495174,0.0020749825,-0.013653837,0.030256663,0.013299835,0.0844433,-0.02717485,0.008976084,-0.0086002685,0.034878965,0.02075623,0.067707546,0.07152364,-0.017221864,0.062531054,-0.0026777312,-0.034980163,0.13914503,0.02850812,0.00036209254,-0.020614227,-0.01611868,0.02083933,0.038107112,-0.023433885,-0.025277166,-0.03767062,0.06349598,0.036442745,0.0074662073,-0.03259143,0.03612014,0.08835497,0.1090343,-0.087832525,-0.07518885,-0.031724587,-0.059927944,-0.0070518036,0.048854455,-0.03441828,0.045147702,0.028103271,0.03870378,0.08762418,-0.010623928,0.009576526,-0.028437706,-0.01824012,-0.09882868,-0.01557456,-0.015493689,0.101414256,0.07194403,0.027791385,0.10981218,0.012218762,0.023160892,0.07390588,-0.057372514,0.08139024,0.11101437,0.042609114,0.017225826,-0.03440278,-0.03062262,-0.079473056,0.019384801,0.045199994,0.018953264,-0.00057899323,-0.025794523,-0.00034390454,-0.07484831,0.021533705,0.11714517,-0.015710201,0.053297766,-0.034761883,0.049920008,-0.01344011,0.03576713,0.12931691,-4.7590408e-08,0.0005306378,-0.084263645,0.042873345,0.0033849014,-0.06376504,0.020631501,-0.015125163,0.019595886,-0.018744145,-0.054778166,-0.14757401,0.10003917,-0.010768101,0.029347047,-0.05778876,0.022594841,-0.0057603894,0.0007832784,-0.021626158,0.013938995,-0.11540426,0.009587149,-0.08412262,-0.0059946394,-0.015890094,-0.075440794,-0.035815783,0.062164873,0.054120373,-0.012258265,-0.02405979,0.042562556,-0.063699104,0.038167432,-0.091180675,-0.003398633,-0.00083447667,0.017292742,-0.00196043,-0.006486207,-0.04615357,0.041517254,-0.028423965,0.018017503,0.02916747,-0.011141953,-0.0043437514,0.07761096,0.008948855,0.041010175,0.049981784,-0.03589774,0.01537373,-0.048284292,-0.11315951,-0.059135027,-0.05277192,0.006500439,-0.024391068,-0.07010526,-0.037930883,0.018817214,0.15399076,-0.035979 +2.5.1.148,"The enzyme, characterized from the green microalga Botryococcus braunii race L, in involved in biosynthesis of (14E,18E)-lycopadiene. In vitro, the enzyme can accept (2E,6E)-farnesyl diphosphate and phytyl diphosphate as substrates, and is also able to catalyse the condensation of two different substrate molecules, forming chimeric products. However, the use of these alternative substrates is not significant in vivo.",384,1.0,-0.08747224,-0.086340524,-0.072019,-0.049643736,-0.027518565,0.08814313,-0.10277862,0.07781674,-0.0025794758,0.06467977,0.089486755,-0.09033403,-0.08876218,0.041297033,-0.026621731,0.036164947,-0.073636435,-0.01730936,0.0018438102,-0.018673396,0.16284688,0.034732815,-0.064316936,-0.038266495,0.044438854,-0.028990492,-0.002410762,-0.04240269,0.019267319,-0.04058981,0.006106561,0.028884035,0.034421697,-0.090838656,0.111289665,0.030555544,-0.005174685,-0.09095538,0.1682299,0.0588452,0.01303422,-0.0521842,0.018945538,-0.033641376,-0.0022445985,-0.022079417,0.0024189535,0.13111329,0.03105765,-0.044827893,-0.055129983,-0.025251534,-0.0062793093,-0.055340823,-0.053279784,-0.03385931,0.043857913,-0.04221883,0.040066462,0.02902924,0.045278523,0.018511621,0.040747322,0.028383803,-0.051258102,-0.110949665,-0.08945737,-0.10953109,0.025590014,-0.05098775,-0.08039313,-0.09375921,-0.04286883,0.036062207,0.05136681,0.064064056,0.04475206,-0.035545185,0.007284799,0.021831093,0.010280793,-0.038023733,0.028473157,0.030272562,-0.0018543099,-0.05114709,0.06890863,0.01933452,0.04898076,0.04555868,0.031102445,0.0027910005,0.009402842,-0.06647667,-0.06564,-0.00095926685,-0.004528322,0.020594144,0.02289453,-0.026744472,0.021132058,-0.057746056,0.0005309404,-0.07301152,-0.02776769,0.0020456936,0.028295381,0.036475994,0.08824108,-0.06397812,0.005873676,0.07311869,-0.008112412,0.00096000615,-0.063939184,0.07750364,0.07215201,-0.0679583,-0.0076338868,-0.003251468,0.018149635,-0.017881297,0.0038907067,0.053083953,-0.029616859,0.015098425,-0.03662238,3.0554893e-33,0.03899599,-0.032606483,-0.006132655,-0.07998373,-0.0024432084,0.01687551,-0.08234741,-0.05455564,-0.00815145,-0.052372426,-0.045719687,-0.05426889,0.002129797,0.060033035,-0.047987554,0.045580816,0.019761505,-0.002596943,0.05760179,0.01290611,0.03976121,0.02409911,0.0031259686,0.056680314,0.10639671,0.09860585,0.036491867,-0.024488607,0.02627853,-0.036628406,0.0422735,-0.10463579,-0.06379838,0.034017265,0.013729027,-0.073472984,-0.03299876,-0.087067924,0.013605305,0.013199594,0.03375403,0.07491413,-0.029743899,-0.061510414,0.06983369,-0.023938993,-0.018292911,0.06421242,0.0065181777,-0.04169176,0.006931736,0.015631532,0.083407745,0.054199006,0.018735088,0.027132388,-0.030508626,-0.008873882,0.087120175,-0.006433186,0.00030439917,0.06331187,0.027481591,0.020413708,-0.00081625866,-0.048094336,-0.027959088,-0.001133633,-0.0077954945,0.063707486,-0.018637082,-0.02725805,0.012348019,-0.03858744,0.01894399,-0.088640355,0.008557817,-0.009300109,-0.01686405,-0.01062957,0.073187314,0.0206255,-0.009571369,-0.030659683,-0.05017951,0.018698446,-0.089368224,-0.029938187,0.038301416,0.04916059,-0.0447726,-0.10909286,-0.08435352,0.02095222,-0.033353064,-5.0173232e-33,0.050197396,-0.06384938,0.063899286,-0.028643321,-0.016163778,0.008131687,0.061664626,-0.003283409,0.0076972824,-0.03058024,-0.022813065,0.037176974,0.057353117,-0.061769214,0.011301839,0.032878205,0.047756046,0.107111245,0.010258071,0.023448667,-0.07085482,0.07591856,0.06516946,-0.019105805,0.066315286,-0.035164557,-0.04751845,0.057168882,-0.010982583,0.031290155,0.02716715,0.017819649,0.033247612,-0.07388085,-0.0072039445,0.01386201,0.014521387,0.0035755145,0.08900892,0.029023983,-0.0062118927,-0.02553373,-0.033670727,0.029547404,-0.005843763,0.019042464,-0.104006305,-0.041036885,-0.080561794,0.0049427655,0.0074422653,0.052957952,-0.022367086,-0.009920385,-0.04120064,0.014584159,0.061509613,0.016969189,0.013712191,0.025567759,-0.02190501,-0.121564455,0.0050943806,-0.06166601,0.05421627,0.11611458,-0.08823962,0.10102497,0.029096479,-0.049416877,0.13629805,0.062489454,-0.015652744,0.036748745,-0.020015616,0.02701353,-0.053614456,-0.05127821,0.04302634,0.012844192,-0.0077024195,-0.012979716,0.010218218,-0.021496154,-0.0015534374,-0.0711569,0.049450226,0.10757928,-0.05983486,0.05079317,-0.011085669,-0.06657848,0.0022360708,0.03561661,0.09777627,-4.601432e-08,0.05374374,-0.06395702,0.08569044,-0.03345729,-0.07857655,0.0025611569,-0.006699085,-0.0016173833,0.047046877,-0.007722993,0.025060678,0.03548611,0.014664983,0.025284862,0.09803582,-0.012238127,-0.06813015,0.0022722257,-0.024500972,0.03425516,-3.9742965e-05,0.01078148,-0.10558821,0.059040576,-0.03506637,-0.059312608,0.032760467,0.03604812,-0.07480973,-0.0755187,0.0006465422,0.06390509,-0.0145056965,0.009836769,-0.08577622,-0.0074423174,-0.07466834,-0.019585634,0.0031473578,-0.011364481,-0.02501761,0.012416005,-0.060152147,-0.009826418,-0.057192005,0.015305847,-0.0015278512,0.02946141,0.008913533,0.026666973,-0.002144211,0.0023918713,-0.020475622,-0.021393588,-0.037435047,-0.016946157,-0.020203823,-0.026047744,-0.033442777,-0.0240974,0.013089554,-0.016092144,0.18641682,-0.08534204 +2.5.1.149,"The enzyme, characterized from the bacterium Corynebacterium glutamicum, is bifunctional. It catalyses the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2, as well as the hydroxylation of the new isoprene unit. The enzyme acts at both ends of the substrate, forming the C50 carotenoid flavuxanthin via the C45 intermediate nonaflavuxanthin. cf. EC 2.5.1.150, lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming).",384,1.0,-0.057450652,-0.07050142,-0.10238824,-0.014962478,0.023467379,0.06637543,-0.08099687,0.079002544,-0.0030538843,-0.04777444,0.04916958,-0.07817614,-0.026668118,0.0049433056,-0.03759263,0.04562515,-0.084639736,-0.02394636,-0.046978567,-0.07576079,0.06134816,-0.0103478525,-0.035345808,0.019413557,0.08708731,-0.014613179,0.049493365,-0.04256778,0.007191562,-0.037715144,-0.011939999,-0.03559172,0.030872425,-0.023532385,0.070264496,0.037922405,-0.077080764,-0.079730496,0.09554635,0.01749107,0.04893006,-0.0041840537,-0.024071101,0.014909362,-0.028070603,0.05462001,-0.021342412,0.08638514,-0.018517788,0.013981814,-0.057012614,-0.07776064,-0.062299367,-0.014540148,0.015451699,0.022496771,-0.06822108,-0.0042598303,0.08390598,0.006328234,0.08742814,-0.0042941603,0.07609615,-0.008408074,0.013987963,-0.07861875,0.00949128,-0.07255433,0.08048739,-0.06406192,-0.045495417,-0.055527855,0.024211938,0.06317419,0.02366429,-0.016188115,-0.036547486,0.03532746,0.0074291816,-0.0179136,0.054059494,-0.00248467,0.021797894,0.057350375,0.025924802,-0.066263296,-0.006809847,0.025861628,0.059438348,-0.008101212,-0.009869421,0.021366553,-0.07871425,-0.04756173,-0.028767254,0.029417045,0.04177935,-0.07377755,-0.03154471,-0.0690156,-0.021920338,0.0635722,0.040638376,-0.025804257,-0.03903806,-0.044559874,-0.010753452,0.060759142,0.013410622,-0.027880441,0.061282516,0.06969146,0.040430915,-0.06438115,-0.024016732,0.035709303,-0.024509348,-0.051888272,-0.07108097,0.02017165,-0.006314127,-0.0076428554,0.023274982,0.042341884,-0.07491739,0.05212462,-0.100324735,4.4873435e-33,0.04735076,0.03887973,-0.015849723,0.014063763,-0.008483303,-0.05021836,-0.057565697,0.07695315,-0.0449482,-0.097948544,-0.13077986,-0.026735434,0.057794143,0.012330812,-0.03982868,0.00550769,-0.024360128,-0.00885057,0.011889417,0.010210647,-0.010076633,0.05593991,-0.03488953,0.045456238,0.0033374005,0.048828226,0.0079921605,0.016160345,0.022164905,-0.00813894,-0.037203297,-0.061246075,-0.08540937,-0.012167029,0.13242614,-0.09403291,-0.07968269,-0.07961926,-0.027938416,0.06998485,-0.02559519,0.032094207,0.0084465,-0.011943188,-0.0010142821,0.012586742,-0.016664943,0.06847322,0.045137063,0.036728997,0.073839165,0.008582703,0.05824995,-0.025553493,-0.071841955,0.043626137,-0.038215615,-0.050694548,0.00030741945,0.005889898,0.03278723,0.081617214,-0.0160173,0.024063284,-0.018242324,0.0711056,-0.112187944,-0.015556362,0.06732922,0.037558686,-0.022439789,-0.07077197,0.041259162,0.024371173,0.055329032,-0.02123555,-0.008466972,-0.051942814,0.021775631,-0.05560559,-0.03107369,0.016058339,0.09150897,-0.050519973,0.00873094,-0.063565,-0.07681423,-0.082969375,0.03247211,0.062467366,-0.045360684,-0.0491202,0.012362667,0.052373305,-0.017406616,-4.896232e-33,0.10294589,-0.13915,0.04064593,0.004391721,0.02722598,0.03259433,-0.029904872,-0.095069885,0.017248876,0.030164704,0.105748534,0.03892264,0.040104717,0.00422787,-0.005481878,0.07792374,0.049258407,0.08785273,-0.06573251,-0.0068330644,0.006864148,0.038060516,0.011694771,0.012712251,0.011823577,0.05376815,-0.007847164,-0.010381672,0.06142559,0.05152869,0.009380928,-0.013939741,-0.025235351,-0.0034896375,-0.03712762,0.09309251,-0.025050571,-0.013042974,0.043466486,0.019930497,-0.00055237766,-0.011865501,-0.022740446,0.03591557,0.022703398,-0.0052137203,-0.0055902083,-0.02946255,-0.08710039,-0.035750683,0.06627081,-0.0088885585,0.0020875342,0.034296382,-0.043367606,0.063317046,0.08891404,0.03268145,-0.029047994,-0.017284637,-0.010721916,-0.102925114,0.051477745,-0.05004616,0.05594093,0.043062627,0.013722799,0.12644526,0.040875304,-0.043428984,0.09935481,-0.008337843,0.025809852,0.031099712,-0.042737603,0.04760035,0.012920107,-0.06765932,0.0073347534,-0.06324612,0.023792794,-0.03564944,0.05340306,-0.0101061035,-0.053483598,-0.10764123,0.011750671,0.046735715,0.0005451707,0.08428337,-0.022247372,-0.013950917,-0.050318845,0.08273903,0.16710241,-4.2494865e-08,-0.0231913,0.025530113,0.02108315,-0.0026609374,0.07589526,-0.017755214,-0.04874904,0.010254566,0.050897248,-0.036965616,-0.04088737,0.0009820866,0.0023235448,-0.013107401,0.011185133,0.0068586,-0.046288013,0.027446916,-0.027039709,0.09038539,-0.08524926,-0.013961623,-0.1064432,-0.018165318,-0.018128578,-0.12483195,0.026622718,0.1011401,-0.00012377759,-0.029143425,0.02984305,0.046331625,-0.037401643,0.011288702,-0.12123087,0.029315444,0.0050242986,-0.004401924,-0.040818486,0.055190127,0.013311039,-0.003257965,-0.072546,0.044439632,-0.022898277,0.016847074,-0.018389458,0.02055684,-0.04942666,0.078458935,0.040966887,-0.0036893205,-0.010485167,0.024398131,-0.04938386,-0.031107636,-0.03115145,-0.009830248,-0.030063737,-0.060428776,-0.029527616,0.064584695,0.20786217,-0.04244461 +2.5.1.150,"The enzyme, characterized from the bacterium Dietzia sp. CQ4 and the halophilic archaea Halobacterium salinarum and Haloarcula japonica, is bifunctional. It catalyses the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2 as well as the hydroxylation of the previous end of the molecule. The enzyme acts at both ends of the substrate, and combined with the action of EC 1.3.99.37, 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase, it forms the C50 carotenoid dihydrobisanhydrobacterioruberin. cf. EC 2.5.1.149, lycopene elongase/hydratase (flavuxanthin-forming).",384,1.0,-0.027335595,-0.061304964,-0.10705009,-0.004096529,0.030786257,0.101380095,-0.07674085,0.07170648,0.00525832,-0.048142392,0.0155651765,-0.1015059,-0.00096779625,0.043272793,-0.03061543,0.05157638,-0.0710776,-0.0002195048,-0.043575365,-0.038851336,0.075898446,-0.016113259,-0.04332469,0.04120403,0.07906722,0.016078826,0.055273786,-0.07632413,-0.052570663,-0.08339298,0.017910931,-0.0441753,0.08289511,-0.044115726,0.105429016,0.023820098,-0.0468248,-0.099425405,0.06628994,0.022854276,0.06391527,-0.004078743,0.0074615376,0.0020291691,0.011081773,0.043313913,-0.03433503,0.08964835,-0.003996453,-0.021299407,-0.0745428,-0.07135616,-0.0397631,-0.010804038,-0.027807988,0.03653192,-0.07783594,-0.0124370605,0.08424008,-0.0030306,0.10786695,0.0031268,0.09142771,-0.03517764,0.02030334,-0.087583445,0.023620378,-0.08760461,0.08540441,-0.058163073,-0.079850465,-0.078852706,-0.0015468919,0.05774309,0.045483608,0.0072363312,0.019192692,-0.01209128,-0.015282463,-0.033027235,0.030994246,0.017333267,0.029997531,0.03753853,0.038937964,-0.038053736,-0.008120398,0.027673768,0.07134851,0.01912081,-0.012687423,-0.0021423753,-0.04427614,-0.0446969,-0.043158554,0.035317123,0.04119791,-0.023313297,0.02185226,-0.055128437,0.000542437,0.043691568,0.010080481,-0.04458474,-0.03904515,-0.039234634,0.013955754,0.07102361,-0.0061497004,-0.040550984,0.041308925,0.021409817,0.030177133,-0.038909927,0.013811958,0.06167476,0.001939884,-0.037548225,-0.076238595,0.028378973,0.0099721085,-0.02076285,0.05974143,0.009889542,-0.052222166,0.07735792,-0.14645648,4.222018e-33,0.05359324,0.02387677,0.00082364783,0.024529912,-0.033532355,-0.06209486,-0.054177407,0.089883976,-0.07558779,-0.1310487,-0.09701522,0.017418528,0.084798306,-0.00641044,-0.046671126,-0.0093990695,-0.0088899275,0.0027804368,-0.017065212,0.017727673,-0.040456396,0.06829135,-0.02378693,0.04861917,0.053659067,0.0020211334,-0.004250931,-0.022505201,0.047122613,0.004925639,-0.020540357,-0.061966427,-0.07970734,0.01620242,0.14915344,-0.05385942,-0.051941544,-0.048141718,-0.078237094,0.05197689,-0.062767945,0.0366347,-0.029384753,0.00236794,-0.008355938,-0.022981161,-0.017992424,0.038993184,0.08626652,0.028656684,0.05510045,0.016862158,0.07540577,-0.06390014,-0.038184844,0.057973403,-0.033258267,-0.026098778,0.018348707,-0.008488419,0.0039121304,0.085187204,-0.038207598,-0.0007963625,0.02552788,0.043738924,-0.09606372,0.0036878737,0.029617356,0.029484177,-0.027618999,-0.075551786,0.090298705,0.05087705,0.070318095,-0.038686175,-0.046383444,-0.042608306,0.026426962,-0.06371961,-0.007083867,0.021443168,0.09365604,-0.06483003,0.015898056,-0.025946831,-0.037806254,-0.059942525,0.024117224,0.08260503,-0.02739962,-0.05162751,0.03275983,0.013424272,-0.01559656,-3.6970083e-33,0.064110145,-0.11201466,-0.046196803,0.03253853,-0.009247335,0.05296984,-0.051158708,-0.08421438,0.010696131,-0.01874436,0.13850047,0.00937636,0.06282983,-0.013687867,0.0071016783,0.054233477,0.06112356,0.057633672,-0.068286546,0.0035136193,0.038159456,0.030536028,-0.0019392851,0.027604723,0.00610796,0.044957735,0.018655227,0.00013145685,0.092917465,0.053436674,-0.0011385472,0.0039774687,-0.023500787,-0.036233705,-0.06381746,0.043069,-0.06738995,-0.00103312,0.03752795,0.024288468,-0.042808946,-0.03860588,-0.020138208,0.021358617,0.053911388,0.018611286,0.010433654,0.0032975196,-0.023270108,-0.01253194,0.0644839,-0.039018355,0.01640295,0.048662174,-0.03692195,0.031108893,0.06528003,0.068349324,0.012285779,-0.013609538,-0.014419238,-0.08182632,0.07190554,-0.053643588,0.08109075,0.005644147,-0.008759123,0.1194223,0.01800926,-0.07133477,0.06782875,-0.0068694167,0.044253353,0.039208177,-0.020057581,0.02145621,-0.058458354,-0.069872506,0.012850045,-0.029755874,0.015650712,-0.0016367704,0.074058436,-0.048622873,-0.026243037,-0.103233784,0.01698797,0.04070131,-0.034314606,0.07775922,-0.0013553,-0.018490218,-0.04813818,0.055947103,0.1467871,-4.2943462e-08,0.022210527,0.015002286,0.021526322,-0.012727995,0.062633365,-0.012037615,-0.031405892,-0.032383204,0.078255795,-0.055170495,-0.011794456,0.01777911,0.046246473,-0.019308275,0.017296812,-0.0009967418,-0.0076923994,0.022655047,-0.021631906,0.09458379,-0.067639224,-0.0111244945,-0.09911011,-0.028312413,0.0029879499,-0.09175306,0.03251548,0.07419318,0.022759767,-0.027014814,-0.005421086,0.038787086,0.020938003,-0.008286734,-0.12846781,0.0032739753,-0.014092203,-0.028886585,-0.041071065,0.07475108,0.0398165,-0.025349082,-0.08859361,0.05205462,-0.010167429,0.02165041,-0.018085945,0.0077840993,-0.08006597,0.018844428,0.019770883,-0.033264056,0.010290673,0.002320749,-0.064716846,0.021280322,0.037546214,-0.039309118,-0.034637287,-0.065343276,-0.05093023,0.060524933,0.17507955,-0.01932044 +2.5.1.151,"This mammalian enzyme, which is cytosolic, can bind internalized methylcob(III)alamin and adenosylcob(III)alamin and process them to cob(I)alamin using the thiolate of glutathione for nucleophilic displacement. The product remains bound to the protein, and, following its oxidation to cob(II)alamin, is transferred by the enzyme, together with its interacting partner MMADHC, directly to downstream enzymes involved in adenosylcob(III)alamin and methylcob(III)alamin biosynthesis. In addition to its dealkylase function, the enzyme also catalyse an entirely different decyanase reaction with cyanocob(III)alamin (cf. EC 1.16.1.6, cyanocobalamin reductase).",384,0.99999994,-0.09373062,-0.042250946,-0.08799374,-0.042795137,-0.055360384,0.0048427135,-0.049103215,-0.025111701,0.00085190387,0.012390045,0.008441911,-0.04493261,-0.055109438,0.07100366,-0.026514996,0.023095725,-0.00060667295,-0.010055373,-0.03064307,-0.09592578,-0.025183383,0.04766394,-0.042477127,0.022649255,0.010593144,-0.014486573,0.03574261,-0.0032220583,-0.019863911,-0.05224236,-0.022525445,-0.08344755,0.010827632,0.008264948,0.015833918,0.079089485,-0.0675977,-0.08285648,0.0489282,-0.012650594,0.017100349,0.046459656,-0.025255881,0.0782347,0.009606157,-0.017700363,-0.020379927,-0.013248594,0.061750766,-0.039288662,0.018781055,0.013625275,-0.09152259,0.112361394,0.095675394,0.035488278,-0.08259915,-0.007504993,-0.0071215127,0.0307972,0.015947312,0.0129535645,0.014418784,-0.007869681,0.066912875,-0.013724457,-0.017188149,-0.012250546,0.00022361378,-0.057990696,-0.0021660519,-0.070335776,0.008484158,-0.028046489,-0.04747399,0.047394104,0.008557922,-0.018399695,-0.057046685,-0.05914895,0.045667045,0.033154428,0.10109321,-0.00046271546,0.035183396,-0.0050153444,-0.06868011,-0.007779304,0.0170204,0.07141758,0.10239888,0.0006258478,0.0026114665,-0.098273985,0.024693707,0.0052923798,0.0640132,0.052020542,0.0076806913,-0.004506321,0.043975864,0.08735715,-0.05577117,-0.06880476,-0.010141449,0.034928937,0.011726816,0.054923564,0.008264486,0.051749025,-0.0191162,0.059497226,0.008338669,0.03824227,0.02168126,0.08305256,0.039571803,0.014150578,-0.0017077335,-0.0006943275,0.009732493,0.028880438,0.034626365,0.058018677,-0.048069213,0.0077829524,-0.07845477,5.0253897e-33,0.029000523,-0.023617072,-0.0111973835,0.010550781,-0.018069262,-0.05057081,-0.09189813,0.035381794,-0.0469573,-0.045348305,-0.041606728,0.0075095585,0.056702465,-0.049435634,-0.07086815,-0.051573817,-0.102236815,-0.048026904,0.04925651,-0.0029280938,0.025318218,0.018619176,-0.042080786,-0.011101523,-0.0400098,0.038398173,-0.060008004,0.070704244,-0.012886627,0.017915068,-0.08160522,-0.025534442,-0.071700156,-0.021028968,-0.015103511,-0.039057624,-0.06659193,-0.01313571,-0.014085983,0.06763214,-0.053212415,-0.023390893,-0.07251671,-0.0016775549,0.011623109,-0.060412,-0.022571677,0.08869399,0.019302716,0.051135607,-0.031608015,-0.0700194,0.06266961,-0.034991316,-0.053196024,0.0071464824,0.045699686,-0.09749953,0.023348648,0.06150838,-0.021313135,0.00909276,-0.10239198,0.048360158,-0.029537488,0.024798943,-0.11404101,-0.025898617,-0.058686074,0.061499372,-0.0006391673,0.023360139,0.064796716,-0.010364655,0.031533074,-0.005939923,0.009859762,0.02496705,-0.053935938,0.015890006,0.02767483,0.019141553,-0.047090027,0.027328257,0.007366988,0.04132851,0.0033421784,-0.042417552,-0.0142504955,0.09409254,0.04198649,-0.008753659,-0.0090696495,-0.022461874,0.030216374,-6.426119e-33,0.15689845,-0.06536151,-0.0128975725,-0.12595816,-0.020399759,0.036966253,0.055320673,-0.06137451,0.03050884,-0.07172109,0.036306605,0.0073353155,0.002565535,-0.023963178,-0.012527615,3.27553e-05,-0.037622433,0.07258194,-0.05928851,-0.006290711,0.018074073,0.03512726,-0.024347799,0.010735591,0.055949762,-0.023851816,-0.032156754,0.11578481,0.0591322,0.07187169,-0.09747466,-0.04886313,-0.06475672,-0.025104541,-0.023838844,0.052312676,-0.057356615,0.027457688,-0.012539704,-0.002593468,0.015335423,0.12308935,-0.045867737,0.10357577,0.056770105,0.14999528,-0.05815844,0.046987303,-0.0050338698,-0.022121724,0.03884804,0.001757132,-0.024555782,0.025458712,-0.007376113,0.115398385,0.07585188,-0.015698578,0.046812616,0.0031099755,-0.026020259,-0.06337449,0.03370579,-0.0754659,0.038785573,-0.02675467,0.008081472,0.08465262,0.0640798,0.06968216,0.05418933,-0.020826126,0.024254814,0.0041686213,-0.022241218,-0.04138558,-0.039704543,0.036582764,-0.031063855,-0.02448102,0.011538518,0.069390535,0.0038430584,-0.06135531,0.027888067,0.041743893,0.055641256,0.16151531,-0.008098503,-0.008803789,-0.048154835,-0.010984073,-0.039563116,0.0707124,0.03149692,-4.728355e-08,-0.012902708,-0.13169335,0.010669593,-0.061885122,0.03393276,0.15863504,0.025156906,-0.006559723,0.04219263,-0.07195686,0.026224636,0.11597708,0.0042867777,0.08009849,-0.094799824,0.051025063,-0.04631687,-0.020493522,0.04727549,-0.091635115,-0.08399957,-0.020108422,-0.08156179,0.03392761,-0.031515475,0.003145716,-0.046132334,0.10790068,-0.066103525,-0.030542152,0.014844006,0.016779877,-0.019783575,-0.05842344,0.00031602007,-0.018667413,-0.002290932,0.026021838,-0.009680364,-0.045529265,-0.053876806,0.015871327,-0.06428025,0.051396795,0.024582,0.0028720112,0.04022867,0.047348864,0.025322476,0.02527242,0.10014558,-0.032357756,-0.019368012,-0.022859206,-0.050833795,-0.030582206,-0.023458697,-0.11879894,-0.03667574,-0.048640862,0.017788531,0.008478048,0.14792593,-0.052164737 +4.2.3.198,The enzyme from the plant Ocimum basilicum (sweet basil) also produces beta-selinene while that from Liquidambar formosana (Formosan sweet gum) also produces traces of aromadendrene.,384,0.99999994,-0.10683065,-0.10728261,-0.07338213,0.024202937,-0.0141917225,0.042427186,-0.022007704,0.006437118,0.064832985,-0.05092695,0.03809918,-0.015032206,-0.02103191,-0.07505249,-0.045934916,0.04310829,-0.001826019,0.043921113,0.040464494,-0.054143213,0.0637862,0.013541221,0.09365675,0.012109763,0.027652007,-0.033554632,0.03089221,0.005748636,0.043300558,-0.099438764,0.09415049,-0.0007980359,0.06963413,-0.110429466,-0.029735735,0.0040104827,0.020462919,-0.028652795,0.038295384,0.012361112,0.03834962,-0.01781022,-0.07335641,0.012917034,-0.010493567,-0.100790784,0.012329245,0.019313691,0.0031416179,-0.042006474,-0.044390935,-0.06887313,-0.12957658,0.01409759,-0.084319174,-0.010396064,-0.01882228,-0.030322216,-0.0039167483,0.13442013,-0.0013921538,0.04445178,-0.032112863,-0.022554858,-0.043893114,0.0067702155,-0.07344975,0.005136829,0.02409051,-0.04261445,0.014641667,-0.07738351,0.009291878,0.035254065,-0.023815667,-0.006353264,-0.022193968,0.021333078,-0.006434232,-0.029393597,-0.046338566,-0.0058296877,-0.04445303,0.098123126,0.031462297,0.02151217,0.0031066064,0.05488184,0.017027805,0.0789917,0.067545764,0.007791474,-0.0919268,-0.007956269,-0.0020310609,-0.02818587,0.046643537,0.036525235,0.054972667,-0.017067336,-0.0289953,0.03469529,-0.048599154,-0.09735321,-0.053185925,0.10559464,0.04901615,-0.023009948,0.10218814,-0.039938,-0.009162429,-0.0660666,-0.042539127,-0.044800762,-0.06858512,0.02486576,0.026831333,-0.03205394,-0.03502926,0.058552906,-0.05763447,-0.04195859,0.025578983,0.023820993,-0.050660346,0.031700145,-0.08926475,2.8972099e-33,0.054108724,-0.0016368418,0.022425767,-0.037985347,-0.012731059,0.073776275,-0.082166746,0.009173392,-0.026009902,-0.07502287,-0.106768355,-0.11305491,-0.04297648,0.02027207,0.041168712,0.02820192,-0.032207187,0.00884271,0.06103167,-0.03938751,-0.019147722,0.0042380905,-0.09190474,-0.023599247,0.03848807,-0.007742631,-0.031524755,0.059383135,-0.0075805397,0.00782499,0.050362486,-0.095719434,-0.0031773613,0.018144922,0.009119304,0.03919046,-0.045096844,-0.07313153,-0.001965734,0.010595071,-0.002537861,0.023350026,0.03286608,0.019710725,-0.056846566,-0.020300347,-0.05221919,0.056462914,0.14134333,0.049876932,0.021344915,0.011826838,0.101226024,0.06558399,-0.044858724,0.063940935,-0.05568344,0.06190467,0.050724853,0.03834519,-0.0413477,0.006429091,0.012419465,-0.06422454,0.012595511,0.051141325,-0.116947256,-0.0050839633,-0.05553721,-0.035656936,-0.043091856,0.0054208706,-0.038304627,-0.07787251,0.06490164,-0.008504338,-0.023697829,0.028983762,0.030773195,-0.012733441,0.015469965,-0.04172478,0.0072505577,-0.01554668,-0.009327246,0.07545972,-0.01541649,0.024455925,0.063294515,0.10889029,0.016985089,-0.10851732,-0.04839789,0.025665937,-0.03890929,-2.758793e-33,0.0048475554,-0.053412445,0.08065847,-0.029433971,-0.03346274,0.07743202,-0.036135882,-0.017808469,-0.053185977,0.0628855,0.00031663987,0.019373963,0.045227848,-0.06457992,-0.06953566,0.05400716,0.051134598,0.10447655,0.048472993,-0.041055348,-0.055943705,0.091197155,0.011797052,-0.014774485,-0.029964602,0.0655773,0.0795694,0.054712042,0.040346976,0.08185065,0.09262738,0.016506448,-0.04456683,-0.01799515,-0.013074832,0.06607532,-0.022933252,-0.045230854,0.015358712,0.04264766,-0.04403669,0.030027645,0.09242047,-0.0016690574,0.07551603,0.026190428,0.011479416,0.002302776,-0.08134241,-0.013274569,0.10417082,0.0050308504,-0.053124256,0.091747664,-0.017088342,-0.0032775833,-0.010078511,0.03485204,-0.06173204,-0.101732895,-0.0082906,-0.041204598,-0.018572688,-0.0065772436,0.06375728,0.01906224,0.019039864,0.07768002,0.020780662,0.006872805,0.02204014,0.020196257,-0.013471544,0.052272744,0.0098688295,0.051606823,-0.008022416,-0.08938138,-0.060481906,-0.026403006,-0.017080259,0.037074734,-0.011012565,-0.07379146,-0.06319205,-0.0022795324,-0.022760063,0.05278577,0.00788381,0.054924026,-0.005764446,0.07022935,-0.0835418,0.057217475,0.13327745,-2.928208e-08,-0.01559282,-0.07718684,0.075462766,0.054383237,-0.0059814123,-0.08869273,0.03795481,0.009768233,0.021261906,-0.010371253,-0.039895445,0.08121098,0.019145602,-0.020575482,0.011456998,-0.026642868,0.057774678,0.04008252,-0.008433015,-0.021418897,-0.036320355,0.036214434,-0.018092599,0.049134217,-0.0038201,-0.11651806,0.03006175,0.08314015,0.047334887,-0.0122156665,0.095116474,0.054893363,0.0066468515,-0.08459813,-0.026209483,-0.024837233,-0.028070299,-0.029513251,0.00060799025,0.051863607,0.016528927,-0.069488235,-0.006706086,0.0045335772,-0.038323916,-0.029978795,0.009283666,0.031683095,0.010645285,0.016920969,0.02136332,0.00898111,0.025125576,-0.05552046,-0.07256682,-0.057228047,-0.020929934,0.026871366,0.0872857,-0.036612354,-0.02308307,0.0021425448,0.18683422,-0.012093767 +4.2.3.199,"The plant Salvia miltiorrhiza (danshen) produces three different forms of the enzyme, encoded by paralogous genes, that exhibit different spacial expression patterns and respond differently to hormone treatment.",384,1.0,-0.02678135,-0.010306265,-0.055940464,0.029340148,0.089377925,0.11113501,-0.07240822,0.018788213,0.05086038,-0.03252347,0.060892146,-0.042430423,-0.059615828,-0.020335676,0.008891073,0.042897627,-0.1238764,0.07781949,-0.034941137,-0.024598908,0.17027983,-0.023705238,-0.0026471452,-0.007764206,0.032272305,-0.029511621,0.0068308623,0.03677411,-0.022729952,-0.116208516,0.04878233,0.02805869,0.032176062,-0.048953615,0.060809497,0.0282997,-0.018091248,-0.1257435,-0.019387256,0.036116537,0.065620646,-0.06527567,-0.07080352,-0.022153199,0.025880903,-0.016893102,0.0005937193,0.012559378,0.047343154,-0.06992349,-0.07063856,-0.16214664,0.027672026,0.023335123,-0.020380037,-0.031516638,-0.062591866,0.010048129,0.04381889,-0.003037305,-0.028893681,0.011168832,-0.015498679,-0.059573397,0.055191565,-0.042448416,-0.026929969,-0.052333944,0.00395448,-0.0399681,0.0026868135,-0.041663986,-0.048479617,0.06385118,0.04066503,0.03773048,-0.021540051,0.03691976,-0.006212353,-0.023398157,-0.005973658,0.03348885,-0.012100303,0.020890124,0.0637761,0.047228906,0.067413636,-0.011390709,0.030053962,0.040290605,-0.037559353,-0.049517855,-0.0610661,0.0067550372,-0.07272709,0.10389548,-0.022464013,-0.004698464,0.007006018,-0.017873049,0.0054062484,0.027970994,-0.0635104,-0.10077263,-0.029746475,0.028819228,-0.02688073,-0.021273864,-0.03877548,-0.0073220525,-0.056961358,-0.038379014,-0.023980794,-0.016011758,-0.010299757,0.05344582,-0.045573983,-0.011396076,0.009633694,-0.07031887,0.031295773,-0.04717718,0.004059813,0.023859406,-0.007901551,0.07542676,-0.116294086,2.1085874e-33,0.10024172,-0.02662978,-0.03538734,0.017061329,-0.0395604,-0.01169464,-0.008018658,0.09506244,-0.026081713,-0.081934705,-0.16317815,-0.060593273,-0.019441277,-0.021042062,0.019595128,-0.040222935,0.04101345,-0.021022523,0.033024307,0.055273365,-0.011003878,0.064325325,-0.038618796,-0.05178583,-0.013184598,-0.0036555843,0.010191926,-0.010417813,0.03227126,0.006291655,0.06714321,-0.056651723,0.011765113,0.03507022,0.019697323,-0.0023268445,0.03666161,-0.053025104,-0.02567509,0.06642475,-0.045014825,0.00831072,0.01776976,-0.010140436,0.067299314,0.0016996112,-0.062252194,-0.024884684,0.047314093,0.017149907,0.009192457,0.08480863,0.14351645,0.038607936,0.015283464,0.023062455,-0.04256551,-0.0043581054,-0.05030817,0.05590538,-0.053145334,0.02491139,0.033557832,-0.008619543,0.055198967,0.09329827,-0.08105666,0.056177635,0.0046231872,0.108445674,-0.043592587,-0.022956785,-0.06271699,0.009120174,0.02838694,-0.035356317,-0.02694084,0.09089802,-0.02170249,-0.039059736,-0.004521713,-0.03122862,-0.03342213,0.122109786,-0.050322324,-0.012114885,0.008609538,0.0055681565,0.0019720588,-0.0044820737,0.1271878,-0.006892145,0.008155117,0.01598494,-0.0037853543,-1.45771365e-33,0.045872618,-0.013481477,-0.0039186087,-0.04235094,-0.0944754,0.117982574,-0.032337766,-0.048991315,-0.0534457,0.07122747,0.0119261,-0.1190775,0.021914557,-0.114604756,-0.030073695,0.016894525,0.0076371124,0.07069429,-0.04027243,0.0028236392,-0.08880424,0.16098984,0.004453586,-0.023693642,0.013027503,-0.0022611015,0.037326872,0.09008991,-0.009799394,0.055348314,0.010244514,-0.0061730915,-0.050739985,-0.071293466,-0.0325618,0.02017062,-0.02704955,-0.005704996,0.103982,0.055232465,-0.010081266,0.03933009,0.014278096,0.080622196,0.08799881,0.015468341,-0.05004002,-0.009176823,0.014516466,-0.0050242553,-0.0013026285,-0.04933857,0.0448098,-0.017303273,0.0033704548,-0.06475606,-0.025576033,-0.03938941,-0.04913232,-0.0078468835,-0.028318625,-0.019928088,-0.010595539,0.050160263,9.860701e-05,0.0193078,0.010062829,-0.02194563,-0.010581835,0.051335577,0.059677657,0.0126093095,0.047057044,0.10715075,-0.033385437,-0.0144614065,-0.05475716,-0.0026410536,-0.049191233,0.040663287,-0.0022197736,-0.05324412,-0.0020210028,-0.08564666,-0.029999051,-0.0054141157,0.013076422,0.0424601,0.05687501,0.019283816,0.019673044,0.05680008,-0.05359694,0.08904203,0.11080681,-2.9971027e-08,0.025459496,-0.080264665,-0.0029440436,-0.024614967,-0.006093731,-0.062727064,-0.015919194,0.034629412,0.01965978,0.0066886125,-0.08340325,0.1200921,0.018261561,-0.0036242306,0.06320053,0.0049819397,0.0943898,0.101455756,0.008223577,0.05704266,-0.014124712,0.002620872,-0.07395123,0.06545166,0.02471258,-0.06766559,0.06458725,0.05320673,0.06438972,-0.0048646494,0.08690583,0.005857662,0.06847412,-0.045525193,-0.09810044,0.06628702,-0.021228176,-0.029306602,0.03469763,0.01672799,0.052089166,-0.07843014,-0.018904742,-0.0073411562,0.03377327,-0.026183177,0.049501453,-0.08321594,0.011287333,-0.034182027,0.002389663,-0.024742315,0.031578496,-0.0025711176,-0.051804207,-0.011057217,-0.015777813,-0.004728528,0.06514013,-0.045758497,0.011582202,0.03087387,0.11366845,0.038868185 +4.2.3.200,Isolated from the slime mould Dictyostelium discoideum. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction.,384,1.0,-0.07697402,-0.02026635,-0.049343154,-0.02188791,0.11454746,-0.013109128,0.005712664,0.08563805,0.014084877,-0.040998016,0.11495825,-0.09100051,0.0014272797,0.0026520423,-0.014815453,-0.022813547,0.009134476,-0.01636887,-0.011558229,0.019932041,0.04538588,0.039676294,-0.01042007,0.049156137,0.0818103,-0.0061211125,0.10073031,0.018888978,0.023093209,-0.1023804,0.02644439,-0.02046272,0.0039736168,-0.06459022,0.111596815,0.050922245,-0.04369794,-0.0040508388,0.084677055,-0.016402727,0.06914445,0.0019535227,-0.0018241432,-0.029982734,-0.10488005,0.038889553,-0.0022377674,0.04494423,0.004451712,-0.034533113,-0.037348595,-0.03809658,0.029457552,0.0068775397,-0.050675683,-0.05243207,-0.013020226,0.03843709,-0.0058882553,-0.032030035,0.015798053,-0.022120083,-0.014288457,-0.008794543,-0.043482706,0.0014190392,0.008579743,-0.03885441,0.04835291,-0.038800575,-0.025765883,-0.030919675,0.045212377,0.0039266455,-0.01572603,0.02326608,-0.005201073,-0.029873902,0.0228233,0.02868903,0.023243217,0.042334743,-0.001281321,0.0024352523,-0.015378623,0.04881023,0.043849114,0.071361974,-0.0027982392,-0.09630751,-0.01639808,0.046776004,0.059889164,-0.028448995,-0.08491182,0.12340344,0.004201806,0.014818434,0.04918843,0.03742604,0.035351858,-0.0066977823,0.004236162,-0.0818503,-0.12879378,-0.001216839,-0.062448286,0.014806684,0.055035554,0.09049256,-0.0056106234,-0.012403967,0.041636564,-0.0063737137,-0.03192607,-0.036775887,0.09531098,0.0011940865,-0.021912437,-0.04233924,0.002852458,-0.056282777,0.04389344,0.007263881,-0.016388875,0.06595034,-0.09584513,5.0421735e-33,0.055677123,-0.043973364,0.018642409,0.030953677,-0.00472389,-0.035020966,-0.01817286,0.026031492,-0.058280006,-0.044419985,-0.05758344,-0.12073728,0.031115444,-0.028047735,-0.13271533,-0.031891365,0.062343244,0.017478805,0.04414551,-0.034391843,-0.06266139,0.12157152,-0.040055525,0.03551674,0.016130472,0.017614594,-0.014399393,-0.06709309,0.09353389,-0.018482314,0.039194785,-0.06912728,-0.09302015,0.07173672,0.04207651,0.012162407,-0.09008228,-0.068139985,-0.035587475,-0.07197785,0.00045858938,0.055176016,0.03977899,-0.0727315,0.09727363,-0.027528735,0.04589553,0.06269767,0.03251204,-0.015924608,0.04299497,0.008320457,0.03197767,-0.04186762,-0.06169642,-0.0020653156,0.0009920321,0.0107557755,0.11963327,0.048893288,-0.046934832,0.17597114,-0.031052835,0.022071356,0.07154919,0.021778686,-0.1752916,-0.041788142,-0.033247504,0.04826966,-0.020643134,-0.04415891,-0.02377043,0.010782821,-0.03161577,0.0017207146,-0.01376747,-0.117499985,-0.0013425599,-0.009615978,0.0505249,-0.013471499,0.024432624,-0.05665763,-0.08108298,0.022758672,-0.035737183,0.013870896,-0.0050872513,0.086559616,0.01838595,-0.06963169,-0.055760432,0.058298208,-0.019398537,-3.814883e-33,0.04101355,-0.042455018,0.003701617,-0.033096768,-0.013799913,0.024257524,-0.020125689,0.052140616,0.0118353395,-0.012884231,0.053086456,-0.02254368,0.05091184,-0.019973079,-0.034718275,0.10218013,0.11323493,0.09435401,0.024879616,-0.0061972565,-0.024033181,0.08619227,0.022536408,-0.02195031,-0.060358837,0.025078801,0.12163322,0.048076935,0.009310833,0.02978749,-0.013090988,-0.018741405,-0.043646224,-0.09306372,-0.05219053,-0.08791108,-0.09752988,-0.06477512,0.021668656,-0.063004635,-0.12863432,0.0101739615,0.03587635,0.09090873,0.04714665,0.04311002,-0.02884778,0.031509954,0.017420135,0.033438955,-0.046913125,-0.025483347,0.014962531,-0.0186236,0.0037062813,-0.005805196,0.030856412,0.031211263,0.0047383835,-0.03176837,0.017812967,-0.010815419,-0.028664578,0.032260492,0.09129982,0.107373595,-0.07010864,0.04177141,-0.026486026,-0.0078494605,0.091274194,0.070190735,0.01911048,-0.019508248,0.014948053,0.020814613,-0.04161142,-0.039353587,0.027257722,0.028494863,0.027522748,-0.0070282663,-0.047522772,-0.051164776,0.02227268,-0.06030621,-0.015859706,0.055254363,-0.00935882,0.01522503,-0.0052987696,0.030102652,0.06778186,0.07891652,0.13028532,-3.0741557e-08,0.0394158,-0.017612865,0.05150682,-0.045084402,-0.055667184,-0.00768281,0.08329068,-0.005018174,0.045962248,0.04082989,-0.039698027,-0.0033382226,-0.022038726,0.0403948,0.075159736,0.020552894,0.035718072,0.061259028,-0.04685124,-0.043497454,0.07415627,-0.06566416,-0.013339473,0.064945556,-0.018032495,-0.04856276,0.08665264,-0.024562756,-0.06327646,-0.07102732,-0.038585752,0.037633616,-0.010090207,-0.03722335,-0.035297465,0.071473345,-0.03742312,0.07772963,-0.048992947,0.0076192105,0.0031206436,-0.038401574,-0.027347336,-0.012917246,-0.07934975,-0.014730682,-0.026426163,0.03103648,-0.029663008,0.00871544,0.062106714,-0.016550697,0.006181251,0.012174334,-0.05195421,-0.07028822,0.021791782,-0.0035471409,-0.041546576,-0.030192634,-0.026828086,-0.0126755,0.097985305,0.049257755 +4.6.1.18,"Specifically cleaves at the 3'-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA. The reaction takes place in two steps, with the 2',3'-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step. Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2'-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3',5'-phosphodiester bonds have been cyclised. The enzyme can act as an endo- or exo ribonuclease.",384,0.99999994,0.0105103785,-0.05338487,-0.02425784,-0.09026771,0.020773139,0.0059939446,-0.086063184,0.00043104507,0.027798856,0.06968594,0.030135637,0.07425701,-0.043965943,0.11060507,-0.04080669,0.054465316,-0.14338814,0.017604144,0.006841967,-0.009147725,0.12918752,0.029093541,-0.019180745,-0.0063865907,-0.020565754,0.03126598,0.05850795,-0.021953378,-0.012413378,-0.03388301,-0.053065553,-0.11104097,0.043186832,-0.034655407,0.05903626,0.12139936,-0.063944966,-0.015120531,0.03860273,0.051887907,0.047888152,-0.021608507,-0.05270426,-0.024797482,-0.027837362,0.005045418,0.030004086,0.04226304,-0.0068123424,0.03358868,0.005399462,-0.040844943,-0.08012008,-0.040284343,0.02010993,0.046635468,-0.07358663,0.016934486,-0.0132499,0.0015049371,0.02931425,-0.0019637912,-0.03346103,0.02212677,0.072218396,-0.059196554,0.055794068,-0.009863414,0.016566752,-0.0143198045,0.012427891,-0.02347265,-0.011776879,0.009258722,0.0008437382,0.0053178347,0.0017169041,-0.029149726,-0.0147938775,-0.01934061,-0.04498992,-0.085535765,0.024684237,-0.00077310327,0.008797278,0.026620973,-0.031416293,0.026254723,0.0036486993,0.020075833,0.014951599,-0.021520836,-0.027145416,-0.009355629,0.011018072,0.05774782,-0.019470066,0.02071998,0.017197646,-0.07174188,0.048369158,0.053745776,-0.03212741,-0.07777975,0.03351678,0.02307448,0.02091178,0.03967083,-0.058258954,0.024830334,-0.041772168,0.066663966,0.07271089,-0.0233956,-0.009117533,0.06553566,-0.002197087,-0.029004993,0.018310094,0.033297762,0.030849624,0.004631595,0.03140022,0.11909708,-0.049876753,0.09433954,-0.06995382,3.0676118e-33,0.01772401,0.004333209,0.038454738,0.0056579974,-0.01097055,0.04115522,-0.06474094,-0.026505748,-0.08108328,-0.061955355,-0.05159258,-0.06546842,0.07105325,0.008284067,-0.052477695,-0.08836084,-0.027195403,0.08281238,0.0051683197,-0.023063088,0.04398175,0.060477935,0.018981708,0.056103002,-0.0032803204,0.023434663,-0.02952744,-0.003732084,0.09827126,-0.03478163,0.000985382,-0.034076825,-0.08701336,0.03404341,0.07000584,0.018708669,-0.029701939,-0.02139828,0.018200051,0.081656985,-0.0010705898,-0.04276515,-0.027575834,-0.024100322,0.070725694,-0.08147471,-0.078807965,0.07451913,-0.015046937,0.0006931955,0.08920759,-0.0548867,0.026158977,-0.017222214,-0.047265895,-0.014036074,0.008633058,-0.0908823,0.018678041,0.0591741,0.039034914,0.10289046,-0.011325077,-0.0056921258,-0.023534639,-0.023933629,-0.055989966,-0.09036184,0.0237534,0.062245704,-0.048212335,-0.028990828,0.058763534,0.0012731553,-0.008117695,-0.0099598095,-0.06121685,0.015444107,-0.043983635,0.04244827,0.03780417,-0.0104342,0.04176697,0.030403713,-0.0021603766,-0.051066,0.011128068,-0.16417,0.005827112,0.072026156,0.05664826,-0.06928964,-0.04315757,-0.031573463,0.030994391,-4.3858793e-33,0.1548674,-0.115206875,0.076599926,-0.035293523,-0.069134004,-0.019459145,0.009965486,-0.03918157,0.008362284,-0.08010465,-0.010695308,-0.016880196,8.379551e-05,-0.04594014,-0.049409833,0.0010353298,0.09038582,0.07105508,0.038283985,-0.007111066,-0.008754628,0.021586299,0.05478183,0.06173137,0.08876813,-0.021084098,0.046088647,-0.014467935,0.0324789,-0.010811548,-0.033840682,-0.024295311,-0.0287359,-0.017292127,0.003212225,0.09840572,-0.1175446,-0.020278221,0.09159238,-0.019050697,-0.025992852,0.006958299,0.010079117,0.018244646,0.02817828,0.05032292,-0.039359547,-0.032119695,-0.08799438,-0.07222672,0.054652933,-0.022423752,0.019628624,0.082814686,0.08180451,-0.06632749,-0.016962789,0.0082778735,0.013565783,-0.011025349,-0.02163752,-0.050502077,-0.014853955,-0.06914146,0.03470591,0.026471308,-0.033577237,0.04780063,-0.022042783,-0.04869633,0.021068482,-0.008667425,0.008557776,0.002725964,-0.004209566,-0.015150187,-0.07947791,-0.052345965,-0.012114768,-0.044989765,-0.081367314,0.037438113,-0.012586568,-0.052467227,0.03858588,-0.11041497,0.030574584,0.10164716,-0.011386587,0.00075163343,0.012851987,-0.047556147,0.048256498,0.079566926,0.09011973,-4.6822002e-08,0.012227111,-0.024245968,0.020617696,-0.061945457,0.0039710784,0.03798422,0.057939135,0.024526687,0.049619332,-0.06831883,-0.020309653,0.015360508,0.05967043,-0.0359589,0.07543609,0.052103125,-0.07442846,-0.015774138,0.018698625,-0.04739927,-0.13433489,0.050202366,-0.18244295,0.076884344,-0.002295101,0.019506108,0.04639237,-0.0030655903,-0.010784724,-0.031498633,0.055786077,-0.041529432,0.04742057,-0.04225421,-0.015294015,0.065605134,0.01972578,0.064043134,0.011963019,0.031350356,-0.03251894,-0.013083687,-0.002410053,-0.0022556512,-0.032917805,-0.014826675,-0.06550156,0.0965889,-0.027420895,0.009418796,0.095784895,0.04304182,-0.028809732,-0.07882058,-0.068232976,-0.009103945,-0.024028337,-0.12455096,-0.020183215,0.014472311,-0.013277967,0.018525604,0.19130361,0.032650348 +4.6.1.19,"A widely distributed family of related enzymes found in protozoans, plants, bacteria, animals and viruses that cleave ssRNA 3'-phosphate group with little base specificity. The enzyme catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending with a 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses the cyclic products in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides.",384,0.99999994,-0.07609359,-0.052287687,-0.07423449,-0.071960635,0.044950128,0.0047062784,-0.06150574,0.008765122,0.031805728,0.12894389,0.033534963,0.021123402,-0.02643794,0.08765284,-0.06717222,0.06711894,-0.1316744,0.0320462,0.009556625,-0.030894047,0.13974126,0.05261939,-0.049585562,0.025004696,-0.008117037,0.0059599243,0.015846498,-0.021659335,-0.0556466,-0.029828269,-0.03939097,-0.055728223,0.03481677,-0.058124445,0.013440412,0.10584493,-0.02815508,-0.025425551,0.0034648222,0.040301498,0.04876142,-0.025614051,-0.014295683,-0.07286627,-0.055322185,0.009742225,-0.08049477,0.07996043,0.052667897,-0.05394004,-0.041797712,-0.10012114,-0.035719503,0.010337525,-0.02811468,0.005282087,-0.034497555,-0.005503973,-0.01404581,0.045908745,-0.013926009,0.021263003,-0.06956448,0.03853208,0.067789525,-0.022458697,-0.022270355,-0.027773993,-0.0076864436,0.02776954,-0.028655736,-0.06303345,-0.0013276922,-0.011347964,-0.0038592834,0.07678253,0.039907627,0.02054803,-0.017441073,-0.052627,0.0025798937,-0.041244432,0.0349214,0.05939328,-0.017060714,-0.010699443,-0.018356048,0.026728477,0.04603607,0.023740698,0.016434573,-0.005864173,0.028215295,-0.017490597,-0.009259399,0.05129137,0.04139758,-0.030004,0.08925424,-0.024791852,0.037101977,0.00848206,0.057189655,-0.13776703,-0.016342828,0.062350895,-0.0359082,0.04500277,1.0354428e-05,0.029979896,-0.035223328,0.024402196,0.019387294,-0.0432328,-0.017910453,0.07939029,-0.004509898,-0.053231165,0.012217862,-0.00050206983,0.066072375,-0.035052467,0.0409601,0.03739618,-0.026137833,0.14733915,-0.13455166,3.5286625e-33,0.009438103,0.0074796625,0.030076101,0.046102345,-0.029286586,0.024635201,-0.047641404,-0.03191984,-0.047176283,-0.05381546,-0.071423575,-0.009426948,0.07964353,-0.020420052,-0.024120381,-0.048213046,-0.013966523,0.037353642,0.03989444,0.03037036,0.029545272,0.009240862,-0.039188508,0.029700637,0.03375088,0.016162848,-0.03666532,-0.024464672,-0.0100856675,-0.023447353,0.031825125,-0.07027819,-0.08875995,0.041249286,0.06786792,-0.008571344,-0.028179158,-0.050565135,0.018957583,0.06247395,0.005414248,-0.04364398,-0.029496303,0.003896257,0.1048995,-0.053375807,-0.11693814,0.050552778,0.019750835,0.06282629,0.056608934,-0.014025395,0.06436381,0.013922609,-0.08391823,-0.020536382,0.0026056601,-0.046206422,0.036771886,0.009566065,-0.0071823853,0.10699931,-0.028032733,-0.0022877103,-0.02241052,-0.028408216,-0.025153663,-0.06380155,-0.006653282,0.09798791,-0.059857775,-0.027426025,0.041949686,-0.030764326,0.046415433,-0.045319103,-0.009149873,0.005930014,-0.038789604,0.0779077,0.03615539,-0.025980508,0.043805387,0.024940504,-0.046505556,-0.038391326,0.0028130603,-0.102546774,-0.07520065,0.09666436,0.087465726,-0.080714956,0.049225543,0.033228587,-0.0021956405,-5.4724574e-33,0.09997277,-0.0842414,0.07745771,-0.0547225,-0.08530287,-0.010514934,0.022697112,-0.029230783,0.013401655,-0.056395672,0.0074524004,0.0022434595,0.032835785,-0.02963936,-0.017960235,-0.0029230204,0.09559363,0.10522704,0.03289693,-0.01273222,0.06070236,0.09294762,0.04439708,0.027431156,0.10226122,-0.05113834,0.009177451,0.08595682,0.0017027698,0.038043268,-0.008995668,0.003765647,0.039669264,-0.010867342,-0.008540644,0.04519615,-0.09235306,-0.049184576,0.106326684,0.034091648,-0.021034151,0.013598813,0.051472325,0.0013750035,0.024620133,0.06862236,-0.031649422,0.023504319,-0.058957394,-0.057854194,0.019002898,-0.008389971,-0.040404234,0.039907936,0.0008545144,-0.03529815,0.014616733,0.047389135,-0.014426139,0.0031483192,-0.006050616,-0.084769964,-0.0017734207,-0.009226758,0.030576358,0.055172138,0.017667318,0.032828957,0.028411588,-0.0076715127,-0.024364837,0.05619599,0.0061974283,-0.018563304,0.03821388,0.010128186,-0.08634171,-0.03709579,-0.018355729,-0.05550439,-0.05492813,0.008104856,0.023013288,-0.07305828,0.006947112,-0.14104126,0.049307317,0.09590486,-0.02540667,0.03206195,0.024729006,-0.04085894,0.012097596,0.054628346,0.13202703,-5.0400406e-08,0.06507319,-0.06866927,0.0289739,-0.078271076,0.03849658,0.019948725,0.044531383,0.02213463,0.08123516,-0.02363953,-0.021121457,0.058119554,0.0366151,-0.005276341,0.09123104,-0.008522511,-0.074284375,0.0040101423,-0.053354323,-0.04190941,-0.063968726,-0.018762454,-0.16616815,0.07063454,-0.007458886,-0.0014246992,0.051914345,-0.016271345,-0.0074048,-0.05011291,0.00065417,0.009628653,-0.04130461,-0.048485376,-0.039089892,0.036883753,-0.034470573,0.010123828,-0.0005539219,0.0014242403,-0.025167795,-0.0137708895,-0.06904041,0.029180624,-0.072016224,-0.031077538,-0.04306316,0.032174885,-0.013734421,-0.031607218,0.07044292,-0.009064064,-0.03837105,-0.104275115,-0.09733262,-0.04436094,0.022668792,-0.073856965,-0.02200933,-0.012574534,0.0030730166,0.031753216,0.20491345,-0.009008702 +4.6.1.20,"The enzyme secreted by the fungus Ustilago sphaerogena cleaves at the 3'-phosphate group of purines, and catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides.",384,1.0,-0.06555335,-0.04312398,-0.07783048,-0.051563725,0.034010462,-0.0045152255,-0.039812706,-0.018618926,0.022804536,0.0891386,0.06207065,-0.026537403,-0.08171068,0.0419042,-0.07687117,0.060106866,-0.094651975,0.016650504,0.05706599,-0.025352426,0.15807742,0.0022366517,-0.057541132,0.062122207,0.0023192817,-0.027765809,0.05368623,-0.0067709694,-0.08220055,-0.06727138,-0.03034162,-0.08908656,0.019152783,-0.07466868,-0.0052754437,0.13913639,-0.04589666,-0.014885066,0.015321831,0.05070452,0.00024521953,-0.08297534,-0.033011585,-0.0157687,-0.08571169,0.014573633,-0.09480133,0.13194239,0.04528045,-0.0143331755,-0.019568846,-0.06522755,0.010990031,-0.045743123,-0.0060724462,0.02446222,-0.058500264,0.026718752,-0.026743114,0.047071256,-0.021149809,0.0047588223,-0.0680228,0.056235824,0.014434167,-0.06386478,0.022442909,-0.060353335,0.012605354,0.02273408,-0.006272301,-0.044886068,-0.017476304,-0.07048626,0.04728895,0.049833603,-0.025944658,-0.025457324,-0.009394889,-0.050906368,0.039821792,-0.011793195,0.04023705,0.038532045,0.01632193,-0.021411462,-0.008414471,0.014167052,-0.007842133,0.02757728,0.0354938,-0.0014220934,0.020231644,0.015062499,-0.0023280499,0.09425235,0.021900116,0.0466843,0.023308385,-0.028785694,-0.004292223,0.049778912,-0.015921975,-0.14693113,-0.0036487202,0.023427457,-0.030685924,0.05236246,0.046977676,0.036447253,-0.018974235,0.031488698,0.021722296,-0.04682181,-0.012564821,0.027517127,0.039278872,-0.048391614,0.016510246,0.00752908,0.009744605,0.013292165,-0.032666635,0.040139686,-0.023779871,0.08081594,-0.087557375,3.3518274e-33,0.0530273,0.015455877,0.0035972903,0.038318362,-0.047890753,0.03964064,-0.03687302,-0.042706236,-0.04308047,-0.011536538,-0.082193345,-0.052886616,-0.013163251,0.02728547,0.014462209,-0.03685452,0.048428997,0.013773344,0.046133418,0.034136426,0.02991188,0.035208847,-0.05556662,-0.003746577,0.045110367,0.064884976,-0.041284148,-0.026277414,0.031489275,0.0028908812,0.03392542,-0.057662446,-0.08326431,0.0618772,0.054455936,-0.023653258,-0.0058479873,-0.033782125,0.040533107,0.03986491,0.035929322,-0.016665911,-0.04460765,-0.025199806,0.082936116,-0.02223692,-0.05460759,0.06291172,0.053861458,0.052288994,0.071663305,0.016214116,0.079596885,-0.0014583692,-0.077076554,-0.008551557,-0.0028852045,-0.037224792,0.029276757,0.02993023,-0.028318541,0.160626,0.030173931,-0.0023051142,-0.04070293,-0.059511397,-0.05953289,-0.08059658,-0.026354317,0.052694764,-0.1037056,0.0025690373,0.014334044,-0.017187972,0.016594095,-0.025310578,-0.012624419,-0.0019843867,-0.02094815,0.03961012,0.034260258,-0.02300216,0.05073923,0.029698381,-0.014578203,-0.004757535,0.025037922,-0.07478395,-0.061223872,0.077354185,0.03161497,-0.085571624,0.011240888,0.026300116,0.032102775,-6.442114e-33,0.08983194,-0.090235256,0.09443921,-0.06527901,-0.092963874,0.033756293,0.004757762,0.0143208625,0.000641386,-0.0404357,0.042145338,0.015847601,-0.012243467,-0.042574953,-0.00902874,0.0041925944,0.07707619,0.11538792,-0.00048049274,-0.028128512,0.021420104,0.102331154,0.024933605,0.03992716,0.10709222,-0.06487264,0.047290333,0.051375683,0.033445276,0.04402595,-0.007800932,0.010410896,0.022411011,0.015814122,-0.014356417,0.025670303,-0.12229561,-0.0030963481,0.07413653,0.02391702,-0.012860405,-0.021421043,0.021961262,0.0057964623,0.032665983,0.07389176,-0.073486924,0.031484123,-0.062253732,-0.06786247,0.008158622,-0.011472381,0.011978979,-0.0010441787,0.0107259555,-0.059849113,-0.00819119,-0.0011558996,-0.004588909,-0.021313805,-0.038462747,-0.024750434,-0.031042732,0.02106633,0.030635448,0.07490739,-0.006597588,-0.033492766,0.0032407464,-0.04468038,0.012926004,0.024104722,-0.01994852,0.013679799,0.03657644,-0.022302,-0.12761094,-0.047554128,0.009946904,-0.014492855,-0.007550876,-0.021523498,0.025693523,-0.064593785,0.03726115,-0.14607584,0.073027454,0.06752671,-0.08188236,0.040183555,0.02010361,-0.0007169863,-0.0052184486,0.02109106,0.10332,-4.822184e-08,0.1002883,-0.03431587,0.061886612,-0.14104891,0.0031481972,0.006803391,0.037056413,0.022509754,0.039882537,-0.06446623,-0.041784745,0.046270408,0.071654096,0.04235071,0.09442968,-0.0068007787,-0.0106049245,0.008223044,-0.02631458,-0.03094389,-0.104631625,-0.01905827,-0.14633983,0.06550263,-0.0026236395,0.014865345,0.11578213,0.0017245671,0.020376593,0.017978936,0.04057335,-0.014792895,-0.03263613,0.021944249,-0.055190906,0.06811432,-0.07287209,0.0113187665,0.001993068,0.014367856,-0.040806532,-0.06320242,-0.025261685,0.022109877,-0.09898349,-0.059478242,-0.022306845,0.04718188,-0.018843405,0.012243551,0.07220894,-0.0002580395,-0.044721793,-0.08934612,-0.07852328,-0.056120146,0.03990552,-0.10181667,-0.037945367,-0.06384451,-0.012044954,0.0070710653,0.17042926,0.0067198626 +4.6.1.21,"Preference for cleavage at Cp-A bonds. Homopolymers of A, U or G are not hydrolysed. CpG bonds are hydrolysed less well and there is no detectable hydrolysis between two purines or two pyrimidines. The enzyme catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending a with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides.",384,0.99999994,-0.04447064,-0.0440816,-0.028007342,-0.0731277,0.028703146,-0.0065118815,-0.0654457,0.001971582,0.019549187,0.041033678,0.041410953,-0.008270765,-0.080930345,0.08699432,-0.015500591,0.04876152,-0.107988246,0.011537189,0.049965482,-0.037781857,0.101535924,-0.012591681,-0.08356167,0.007621074,-0.0090146875,0.001294432,0.0039830343,-0.04032968,0.010929248,-0.043547343,-0.008260818,-0.112800874,0.028823864,-0.065833405,0.06578696,0.15228674,-0.024165723,-0.03194756,-0.036362715,0.030307824,0.054699596,-0.039792396,-0.05078796,-0.004935801,-0.039649796,-0.0047675795,-0.044535264,0.085628174,-0.05326911,-0.009117348,-0.0044436213,-0.08964269,-0.056817822,-0.04353805,-0.011091926,0.0064763,-0.0930881,0.0729196,0.014679346,-0.006291403,-0.08944378,0.05787939,-0.08542598,0.03699354,0.06304921,-0.05960652,0.0460072,-0.045517884,0.017665327,0.065539375,-0.027342815,-0.07663246,-0.02589425,-0.012393117,0.010584194,0.061386712,-0.06035394,-0.05176554,-0.010336611,-0.05135417,0.024670603,-0.053282436,0.05376181,0.027092073,0.03256216,-0.0155843515,0.00010468697,0.014844144,0.019679774,0.010333107,0.0589567,0.028525244,-0.011148596,-0.0044665025,-0.0087009985,0.061617076,-0.01138767,0.014013898,0.057125524,-0.023901492,0.048772454,0.057375,-0.037453767,-0.12551945,0.028235368,0.06668925,-0.012174583,0.04519865,0.039453793,0.020614062,-0.033753626,0.049300022,0.022809874,-0.057378273,0.008931521,0.07862562,-0.010516323,-0.047868993,0.07960695,-0.008936515,0.04724445,-0.055355962,0.04123008,0.07553015,-0.033895053,0.07551241,-0.092595786,3.6178112e-33,-0.012971072,0.01228388,0.046433333,-0.004377834,-0.080517896,0.014955983,-0.04634686,-0.011350566,-0.039098218,-0.019642737,-0.03420965,-0.06549921,0.051707324,0.05388025,0.0057261866,-0.07577409,0.015474733,0.060520176,0.028098967,0.025064625,-0.014110202,0.06819247,-0.014062788,0.03464873,0.040298253,0.014360802,-0.038465496,0.023643175,0.028864207,-0.01177017,-0.0043680095,-0.07588805,-0.07094244,0.0856474,0.009228501,0.040667955,-0.04960699,-0.035672057,0.021826716,0.053419456,0.012172949,-0.044681177,-0.04644952,-0.00862365,0.09969032,-0.058443714,-0.032098897,0.0083662765,-0.05136808,-0.00044556835,0.08188351,0.0087647345,0.016175037,-0.00081646483,-0.08641713,0.028538229,0.0039969366,-0.03801822,0.026159327,0.021789802,0.009438417,0.11721987,-0.017348476,-0.04785996,-0.03617614,0.00058639125,-0.07117117,-0.07552488,0.0072866436,0.06470529,-0.056959283,-0.025581483,0.045206986,-0.0015352828,0.06498142,-0.009778889,-0.01630946,0.046674944,0.028452663,0.022956934,0.0138122,0.02254567,0.05012447,-0.013368382,-0.04573546,-0.056673147,0.019633515,-0.094525754,-0.05199941,0.112076014,0.042083044,-0.092198804,0.037286274,0.018405737,0.030927245,-6.642513e-33,0.088463105,-0.100021414,0.0809406,-0.07961394,-0.08466187,-0.010671986,0.03546056,-0.067520425,0.041735504,-0.09796819,0.019513559,0.0030001686,-0.0039666486,-0.030156074,-0.0285979,-0.0010690823,0.016971936,0.080858424,0.008899171,0.009462353,0.030817544,0.09862448,0.06746277,0.10620601,0.11083137,0.0028963638,0.02217596,0.013967821,0.12701403,0.034745004,-0.011173095,0.011040582,0.013241623,0.0022347276,-0.000911313,0.06790674,-0.11882844,0.036717568,0.077636406,0.009510486,-0.029531188,0.0048396117,0.051338926,-0.011570193,0.037165668,0.06061559,-0.026860297,0.017391074,-0.09868914,-0.046518654,-0.021679113,0.028713139,-0.08288526,0.039909627,-0.0040780287,-0.014879699,0.026384799,-0.004961015,0.0068895994,-0.030593524,-0.042806875,-0.020079184,-0.015835755,0.010333196,0.036164332,0.030620703,-0.00051134476,0.037769213,0.013074958,-0.03383168,-0.026098568,0.06789275,-0.006049142,-0.022565799,0.0026171075,-0.020050628,-0.054206323,-0.0756387,0.02851169,-0.084158875,-0.05690559,0.009171323,0.014276641,-0.025394183,-0.018874155,-0.12381773,0.05087288,0.0458729,-0.0084884865,-0.0017534395,0.030610774,-0.048615944,0.004975665,0.07417243,0.073366396,-4.9674583e-08,0.02720492,-0.07751182,0.039301593,-0.079953976,-0.025927871,0.0038140425,-0.01936625,-0.007859111,0.051269494,-0.09926654,-0.0031826748,0.04067689,0.0575611,-0.035823077,0.03441124,-0.023720354,-0.07255449,-0.008214454,-0.022499103,-0.035465643,-0.13554598,-0.00341173,-0.15029672,0.08935714,0.008890396,0.019971542,0.04498898,0.019441959,0.011695563,-0.02913966,0.07205983,0.023668919,-0.049021073,0.007945669,0.07574691,0.065554634,-0.01301197,-0.004560999,0.010105541,0.03405291,-0.0067656566,-0.057907224,-0.02350038,0.027950952,-0.017741613,-0.033950064,-0.013281562,0.026460629,-0.03937888,0.040810175,0.07871919,-0.01578452,-0.061134804,-0.10015753,-0.028733656,-0.07393321,-0.011911865,-0.07071662,-0.038384296,-0.051348142,0.022755852,-0.003779095,0.2222469,0.0010817909 +4.6.1.22,"This enzyme catalyses endonucleolytic cleavage to 2',3'-cyclic nucleotides. The cyclic products may be hydrolysed to the corresponding 3'-phosphates by 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16). The enzyme from B. subtilis is inhibited by ATP.",384,1.0,-0.060745668,0.021267133,-0.045099463,-0.07539073,0.025488747,-0.058563687,-0.056845397,0.03083201,0.014491985,0.04023631,-0.009806004,-0.053470835,-0.02373187,0.06993243,-0.030494617,0.077115186,-0.09478716,0.05553162,0.09827195,-0.07149064,0.1234879,0.051872943,-0.0018448537,-0.015719458,0.015318775,0.042291313,0.019054279,-0.053667493,-0.0074697956,-0.007828305,-0.043335225,-0.07250173,0.042446416,-0.05175625,0.042129446,0.08125007,-0.09524796,-0.018372538,-0.00024495443,0.039772566,0.05745033,-0.00996462,-0.035250172,-0.017497757,-0.05134245,0.0014639131,-0.034221966,0.09256598,0.033830237,0.024667636,-0.023072088,-0.043563496,-0.03897801,0.0041702283,0.02278645,0.019166114,-0.07924633,0.019896531,0.0023950464,0.07332525,0.048259098,0.02265558,-0.05059765,0.013324032,0.10540734,-0.081821784,-0.00076582114,-0.02504199,-0.0017408945,-0.016087754,0.0016049003,-0.09009868,-0.06385801,-0.014074375,-0.002696942,0.042650383,-0.03160224,-0.0493491,0.00953015,-0.12258731,0.0717256,-0.018418325,0.072478406,0.054486763,0.051926956,-0.015016229,0.0555575,-0.0034372283,0.025980808,0.06155727,-0.0033122082,-0.053169914,-0.032302935,-0.023287289,-0.022201573,0.044906087,-0.035161234,0.03263889,0.043424215,0.03406463,0.06583888,0.11200979,-0.026939303,-0.09687259,-0.07013625,0.025943957,0.0067850524,0.020019718,0.0136806695,0.060982984,-0.029973343,0.01419638,-0.0052983896,-0.08405059,-0.050798643,0.14474478,0.02380337,-0.0065871673,-0.01134161,0.013950657,0.05804178,-0.0423382,0.025291901,0.08416304,-0.0001519162,0.090337485,-0.09151201,7.8293875e-34,-0.0696096,0.0035391208,0.011036631,0.028473115,-0.07867761,0.028809747,-0.074060515,0.011814235,-0.093674675,-0.04757447,-0.04579815,-0.08077883,0.081015185,0.004521884,0.023634585,-0.074774995,0.0486686,-0.0030417505,0.04919577,-0.04781897,0.038416248,-0.004287244,-0.032727152,-0.0027901167,0.022925042,-0.009544001,-0.02977268,0.036965903,0.07133967,-0.0011754934,0.07350587,-0.07093427,-0.09880425,0.024565678,0.025882982,-0.047590513,-0.039100505,-0.0712148,-0.014176671,0.07149801,-0.072343305,-0.05172058,-0.0009222626,-0.038801074,0.05551967,-0.09174711,-0.024083078,0.060452282,0.037007593,0.03961514,0.04338604,-0.025372988,0.075009346,-0.021146005,-0.041326754,0.0061200806,0.026326666,-0.03352266,0.019539075,-0.019526917,0.025072508,0.044530295,-0.0479065,-0.0028918092,-0.03947884,-0.011524286,-0.050256085,-0.07516332,0.010815292,0.06424126,-0.06294333,-0.019049382,0.079857044,0.016814608,-0.016184844,0.02391877,0.034315888,0.026322164,0.006268998,0.046776883,0.04612447,0.006836423,0.10028693,0.0006008672,0.02348805,-0.036761023,-0.04975942,-0.11184024,-0.045612555,0.07363348,0.07607424,-0.05742551,-0.04897304,0.08700182,0.026044272,-2.4939988e-33,0.11719236,-0.037012044,0.038162444,-0.13691853,-0.096696086,-0.017861372,0.0035692162,-0.010926601,0.0005023655,0.01781842,0.037911024,-0.042822853,0.057228263,-0.044330157,0.030464267,-0.011989628,0.0652027,0.05786965,-0.026031466,0.011905359,0.016052073,0.14003031,0.07693988,0.0045796246,0.056589905,-0.012212752,-0.023486014,0.088653065,0.042120654,0.07525721,-0.04854812,-0.047688838,0.02748288,0.0062959776,0.029113254,0.062319335,-0.033763643,-0.023543175,0.03145159,-0.0008275673,-0.02673703,0.06567168,0.04002622,0.0018662885,0.092048205,0.013267947,0.026819797,0.06428698,-0.08183286,-0.08523115,-0.00011141806,-0.02348446,0.0023951693,0.0076614153,0.05398672,-0.030461162,-0.00389634,0.022405751,0.019708123,-0.055143468,-0.027557697,-0.039521504,0.03301012,-0.048249967,0.053596504,0.06030033,-0.04333085,0.057356965,0.005061212,0.0019671097,0.012767409,-0.0030812446,-0.03444538,0.0022516823,-0.017633213,0.016997442,-0.006316801,-0.014022046,-0.009643416,-0.15536736,-0.04338351,-0.028753115,-0.04255252,-0.069627516,-0.0041945507,-0.09315997,0.012202298,0.065267354,-0.032054637,-0.0015635873,-0.000906378,-0.03751967,0.012676467,0.057572372,0.05887286,-3.8078323e-08,0.059256773,-0.056962837,0.054927323,-0.09108418,0.10121866,0.03551563,0.017060239,-0.020229388,0.076694734,-0.01078419,-0.020104384,0.014415095,0.057838198,-0.018544758,0.063611336,0.0115769915,-0.03418894,0.054206815,-0.04420339,-0.041408606,-0.05692944,0.021075238,-0.13584907,0.050957058,-0.03148951,-0.027538534,0.022656687,-0.009695502,-0.032748364,-0.07132994,0.028732736,0.05933457,-0.023710074,-0.008343661,-0.07662589,0.053869355,-0.0145582445,0.049601708,-0.05028317,0.013819106,0.018005313,-0.0028354106,0.00052942405,0.053009093,-0.04232933,-0.0019073546,-0.025646169,0.011675805,-0.046665143,-0.004132841,0.059656683,-0.042441092,-0.014596839,-0.081595205,-0.07313807,-0.11046885,-0.021134544,-0.06477206,-0.021531895,-0.034643684,-0.02749884,0.027916994,0.16212787,0.012891692 +5.1.1.23,"The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyses epimerization of the terminal L-glutamate in UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate. The reaction proceeds only in one direction and involves an adenylated intermediate. The combined activity of this enzyme and EC 6.3.2.53, UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase, provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3, glutamate racemase, and EC 6.3.2.9, UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase.",384,1.0,-0.038196396,-0.071914844,-0.0015808244,-0.06537489,0.012178074,0.047420423,-0.07922724,0.039773576,0.04434611,0.042477023,0.01015726,-0.007834397,0.050807085,0.08017367,0.00011966776,-0.009100078,-0.07076882,-0.0518454,-0.05679245,-0.006353145,0.048698522,0.062475055,-0.037775822,-0.04057732,0.05643215,0.059545152,0.087812446,-0.018461533,0.015427164,-0.09360922,0.015633235,-0.10847139,0.028707813,-0.037336856,0.027924165,0.020562684,-0.05011262,-0.01745318,0.063252255,-0.017319648,0.02131296,0.06220492,-0.03639964,-0.09082276,0.009607349,-0.062322617,-0.009067715,0.01324968,0.0368321,-0.024366075,0.06273791,-0.076174326,-0.011170515,-0.013764451,0.047062874,0.048383277,-0.05817813,0.004256554,0.033660814,0.042632315,0.020598,0.065865226,0.02210073,-0.041612536,-0.06586215,-0.09090989,0.052985318,-0.050722487,0.045035884,0.020601384,-0.07975991,-0.079501756,0.029961718,0.030973157,0.03591839,0.0009031104,0.06376906,-0.020905707,0.014959184,-0.046977233,0.017283902,0.0015790502,0.07507721,0.021079054,0.04042047,0.0054760226,0.0009950461,0.018212583,0.06859421,-0.0050721336,0.053281747,-0.065240696,0.02095179,-0.040875416,-0.005880916,-0.017535772,-0.0048815086,0.022275072,0.058206808,-0.0072594634,0.0030199084,0.050885312,-0.05214378,-0.08695876,0.004898839,0.026508257,-0.0275613,0.11034469,0.03255883,-0.057926215,-0.009681036,-0.020031078,0.048069227,0.030300632,-0.07174552,0.07550481,-0.043886203,-0.045814514,-0.016970165,0.025525194,0.056807484,-0.013832481,0.03890763,0.08686519,0.005342194,0.037158765,-0.056956045,2.2130755e-33,0.009565451,-0.011402975,-0.02135366,-0.03551141,0.007772565,0.00739591,-0.078453325,0.081793316,-0.00026397937,-0.052879155,-0.037105255,-0.040119812,-0.009943386,0.037183028,0.002096105,0.005635561,-0.025421927,0.043903954,-0.014989814,0.0062552774,0.0064383517,0.0060530007,-0.027899196,-0.01203768,0.064980835,0.056859195,0.05024563,0.030484397,0.10100992,-0.016404156,-0.09482985,-0.099177405,-0.094174035,0.02023146,-0.029896514,0.016223112,-0.017848954,-0.033623796,0.0446059,0.08439558,0.024766462,0.0399782,-0.07021729,-0.0016508251,0.032558013,-0.0033975577,-0.047367327,0.07969578,-0.02870464,0.041659486,0.047396883,-0.07797983,0.10037072,0.02054714,-0.074394256,0.038695708,-0.07656776,-0.030053036,0.072697096,0.01234315,0.0657907,0.0568045,-0.007840646,-0.011481324,-0.0069291107,0.0056340494,0.024356218,-0.036088303,-0.017283842,0.04134764,-0.063514985,-0.0027542268,0.108251736,0.039894518,-0.014609994,-0.09206752,-0.034281503,0.04261528,0.05498951,0.011588922,-0.034819815,0.05076226,0.02470445,-0.01408251,-0.006423083,-0.033031106,-0.013987547,-0.06514019,-0.067304246,0.100168996,-0.018546678,-0.044378348,-0.021907706,0.08802579,-0.02793677,-2.3396885e-33,0.080169335,-0.08393901,0.06630853,-0.032125857,-0.102953106,0.07998562,0.024983859,-0.05345817,0.035975717,-0.081781074,-0.000481422,0.017706394,0.065109454,-0.0665695,0.028101962,0.0023393955,-0.03408545,0.08358587,-0.05381653,0.018199684,0.0035373026,0.004652485,-0.010972362,0.015011028,0.08896547,-0.0024091857,0.021155288,0.024115382,0.047117464,0.073115885,0.0053244843,0.02266594,-0.034863252,-0.060260758,-0.07561292,0.10319254,0.036872547,-0.016377067,-0.040753745,-0.0050132233,0.008734745,0.12730426,0.0044566886,0.066697,-0.008858564,0.13895917,0.0024179243,-0.033290632,-0.020985046,-0.030874973,0.031166565,-0.015567048,-0.031049425,-0.0047495845,-0.058597166,0.05861796,0.05285539,0.0014750995,-0.035673093,0.003006624,-0.036068283,-0.08487875,0.0112191625,-0.02916789,0.03998778,0.041358024,0.05337829,0.055522963,0.039350595,-0.04466334,0.041024245,-0.052588034,0.009396243,0.052173197,0.0006139194,0.068853,-0.04251278,-0.09684583,0.02770213,-0.067207865,0.016376799,-0.022794709,-0.026052574,-0.038636193,0.024286661,-0.038527545,0.035361648,0.17917903,0.029401274,0.048546597,0.0022507897,-0.06937531,0.03153489,0.060743432,0.09126648,-4.9171224e-08,0.080060795,-0.09749794,-0.023202108,-0.037274983,0.030757437,0.03712662,-0.084409654,-0.030029042,0.034579523,-0.070432544,-0.011258153,0.01736679,-0.072813176,0.01785888,-0.062060673,0.052426785,-0.029123126,0.038396627,-0.013019519,0.038153466,-0.13486636,0.0205661,-0.11228643,-0.005228691,0.06414504,-0.08427704,0.029498208,0.0947964,-0.036421385,-0.016511926,-0.095533624,0.037051797,-0.074914865,-0.013295315,-0.03264673,0.008005192,0.020855969,0.0012279324,-0.02412453,0.009813583,0.0665259,-0.050119974,-0.06560341,-0.013481145,-0.0014464394,0.007619378,-0.009561679,-0.014897723,-0.039362844,-0.026473684,0.063700885,-0.024370227,0.039972775,-0.112971686,-0.12031144,0.033020172,-0.07110217,-0.11611831,0.019909129,-0.030828178,-0.011050914,-0.010417197,0.14276516,-0.008174061 +5.6.1.2,"A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa).",384,1.0,-0.01795108,-0.052803766,-0.012793717,-0.06026345,0.025644997,-0.005956589,-0.02309768,0.027852383,0.027514393,0.014211798,0.030349296,-0.041971177,-0.032061912,0.03637216,-0.035310987,0.03771165,-0.09727838,0.083104335,-0.051561516,-0.08372315,0.04764958,0.0078092297,0.031239757,-0.013854109,-0.02319685,0.029401291,-0.044437196,0.023796957,0.00091779954,-0.072654046,-0.03618532,0.022721931,-0.06960076,-0.012865651,0.051435083,0.08729959,-0.049372688,-0.07071935,0.055405457,-0.041059762,0.10701562,0.0036506203,0.066027954,-0.006674296,-0.057540946,0.026663635,0.015766561,-0.028898735,0.06440062,-0.017754259,0.011231453,-0.09526343,-0.050236646,0.08390625,0.026140757,0.04617212,-0.08881328,-0.012186925,0.050966304,-0.03118715,0.04758255,0.022200322,0.021924336,0.023754979,0.1054282,-0.06414507,-0.025552358,0.0005462347,-0.013320469,0.012257281,0.014242592,-0.12866612,-0.05291629,0.05534049,-0.030591175,-0.031269718,-0.069611475,-0.0147074815,-0.023573456,0.04225907,-0.022149025,-0.002057461,0.04809066,0.00558231,0.05742287,-0.020891255,0.037490685,0.057055585,0.03267779,0.03053972,-0.026551625,-0.0076390826,0.0071401913,-0.0037201252,-0.04151398,0.0013765224,-0.012814772,-0.017751496,-0.007895051,-0.022492232,0.08216329,0.067407005,0.08311685,-0.010390709,0.032650173,-0.0051348056,-0.015068515,0.099432655,0.01672759,0.053481437,-0.0086794365,-0.022679301,-0.013087792,-0.025275843,-0.018758088,0.018908124,0.051660653,0.044588238,0.015713222,-0.015380332,-0.01674523,-0.08106615,-0.035049736,0.0024565589,-0.060623676,0.036190387,-0.14728059,9.532089e-34,-0.021674968,-0.14401825,0.055620763,0.0075993435,0.018703474,-0.04324963,-0.077300526,-0.052799974,-0.006581575,-0.030471923,-0.0783201,0.05988888,0.062005553,0.02860815,-0.09279967,-0.10003639,-0.0042442726,-0.02939887,0.0902008,0.037091706,0.051768955,0.083111435,0.007305188,-0.03337506,0.06490459,0.0011226154,-0.027009562,-0.01670322,0.023793682,0.015155651,-0.052840233,-0.10708853,-0.09709711,0.028897965,0.023356184,0.016768437,-0.03005325,-0.063790716,0.013239778,-0.0027931246,-0.094064415,-0.02083585,-0.038295086,-0.08935253,0.0052416245,0.04250517,0.04127311,0.00804551,-0.035390917,-0.0049232477,0.06799668,-0.07294514,0.019824743,-0.02589012,-0.031795423,0.045749612,-0.009389993,0.0675572,0.0019380627,0.06410266,-0.025543002,0.040209353,-0.041700676,0.055203084,0.08414012,0.08345325,-0.15050031,0.017597849,0.060921997,0.03307536,-0.10706356,0.04768542,0.10901301,-0.04165167,0.07416816,0.042574015,-0.046046488,-0.090586945,-0.112958156,0.10612888,0.01321523,-0.056789536,0.04624074,-0.019932851,-0.002202412,0.0023647828,0.025249468,-0.025460199,-0.046531603,0.0051889373,0.11238641,0.020545358,-0.005642037,0.07786214,-0.031774182,-3.3521436e-33,0.036234498,-0.059315726,0.043977126,-0.060997196,-0.025714947,0.013599175,0.01568988,-0.07793611,-0.038409926,0.04456857,0.029393258,-0.011919597,-0.11245844,-0.03858926,0.014115664,0.012142108,0.002067382,0.013432988,0.032661673,-0.005641435,-0.0772882,0.10954929,0.046924725,0.04914881,-0.04219398,0.02200116,0.023254693,-0.051486343,0.006779396,0.013798192,-0.044635974,-0.042281765,0.01998154,-0.0024455183,-0.038954623,-0.0036310018,-0.022706768,0.028776392,0.05698079,-0.011334801,0.06094023,0.04937291,-0.023897918,0.033280876,0.010837912,0.031127373,-0.052202217,0.04133291,-0.10279646,-0.040573873,-0.008230599,-0.023040505,-0.0075352183,0.011541714,0.06101473,0.0073694023,0.04514326,0.044432778,0.046625387,-0.044113055,-0.067503445,-0.11040655,0.03600783,0.027246702,0.041922066,0.065869085,-0.0734987,-0.0375269,-0.07154269,0.068987414,0.013672054,0.022185143,0.031058129,0.009462233,0.051459983,-0.016512416,0.03157362,-0.04235624,0.0021203335,-0.0065849884,-0.049908713,0.021236157,-0.04057727,-0.1009171,0.0554843,-0.0845697,-0.012485633,0.10728918,0.018067596,0.017270511,0.0844648,0.018049158,0.001982333,0.03242117,-0.001193064,-3.710559e-08,0.032220095,-0.046954557,0.019902745,-0.055102866,0.027301354,0.0690152,0.07778322,0.08854586,0.10271185,0.020790115,0.09365231,0.04581083,0.02575642,-0.0037179731,0.044209395,0.083343714,-0.020558983,-0.03172599,0.0041438476,-0.06535066,-0.06755876,-0.068552546,-0.07160839,0.11352485,-0.016060045,0.006851916,0.040422313,0.0441161,-0.07084463,-0.08423523,-0.024021946,0.038058724,-0.037242256,0.0009238602,-0.10462209,0.03338792,-0.0003066503,0.0010287496,-0.022259494,0.050651982,-0.031293947,-0.056812033,-0.04573037,-0.021019675,0.024494685,0.06281383,-0.022983106,0.07714524,-0.014057556,0.03940714,0.029567562,0.028215157,-0.010692408,-0.014738611,-0.072414145,0.011487903,-0.058704793,-0.03688473,-0.05944976,-0.04238096,0.045678448,-0.018129319,0.12766202,-0.028787274 +5.6.1.3,"Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyse ATP. The enzymes described here move towards the plus end of the microtubule, in contrast to EC 5.6.1.2, dynein ATPase and EC 5.6.1.4, minus-end-directed kinesin ATPase. They are involved in organelle movement in mitosis and meiosis, and also power vesicular trafficking toward the synapse in neurons. The motor domain, which contains the ATP- and microtubule-binding activities, is located at the N-terminus while the C-terminus links to the cargo being transported.",384,0.99999994,-0.08842455,-0.0755876,0.024108933,-0.08913668,0.00902131,0.05789216,-0.026315637,0.020015365,0.09620381,0.05042052,0.04863639,0.02658543,-0.001130463,0.02520351,-0.03470354,-0.04131754,-0.059238415,0.07088954,-0.104308255,-0.05215491,0.077907115,0.040137313,-0.017486937,-0.005159746,-0.011663437,-0.003356396,0.025430905,0.0022777317,0.0010449485,-0.01791138,-0.08568755,-0.04268985,-0.13163528,-0.015924096,0.04011297,0.101666935,-0.0014808587,-0.08179324,0.02116717,-0.05088834,0.14282851,-0.06705603,0.06373935,-0.004617619,-0.008519712,0.033334382,0.038597647,-0.025065381,0.08340367,-0.013091049,-0.030662082,-0.11800384,0.020214204,0.0032661692,0.0008212064,0.026980992,-0.018836394,0.05553442,0.049781397,0.017602066,0.049235065,-0.0039140754,0.07112246,0.008778242,-0.007534893,-0.09509421,-0.027086928,0.0138232615,-0.026636446,-0.026994908,-0.011232094,-0.058177803,-0.057840854,0.08093253,0.03773537,0.03795632,-0.04782591,0.00013504623,-0.009876539,-0.067732476,-0.0148982685,-0.037410326,0.089925565,0.06868924,-0.0033320903,0.04811472,0.021714963,0.00041804026,0.037980963,0.00918201,-0.03713371,-0.06936459,0.008011187,-0.06412951,-0.050251853,-0.057138804,0.02422584,0.008125792,-0.010658605,-0.004855907,0.019059423,0.1048397,0.022006836,-0.02743318,-0.02660326,0.021151694,-0.03613962,0.025616253,0.01251734,-0.03617976,-0.030629681,-0.018884718,0.042075172,0.0790629,0.000264152,0.008267409,0.004253794,0.0626955,0.0780265,0.006218431,-0.05363173,-0.0009269161,-0.013360764,0.07573431,-0.07336643,-0.023579434,-0.1399167,-2.2491076e-34,-0.006697839,-0.11401193,0.05046645,-0.0071508414,-0.016216239,-0.042196855,-0.10145395,-0.038788427,0.06369712,-0.0043872204,-0.10312162,-0.007992754,0.04809422,0.026625725,-0.027601631,-0.09644529,-0.030023376,-0.034902368,0.049684443,-0.011019898,0.047172885,0.079423,-0.0071450905,-0.005997999,0.034115694,-0.025281886,-0.08705031,-0.0004875736,0.0492988,-0.0089286715,-0.05016757,-0.07528416,-0.09728184,0.019227566,-0.029766336,0.043572947,0.0024420365,-0.042154726,0.03442816,-0.023363693,-0.03605595,-0.06849132,-0.07685839,-0.060353205,0.0043600136,-0.013799893,0.024578368,-0.013937491,0.01115839,-0.050939523,0.04336815,-0.05785607,0.112619475,-0.056043368,-0.03346396,-0.032264844,-0.026544021,0.023612829,-0.021869982,0.058536183,0.091163315,0.03172632,-0.017070144,0.027965015,0.037277788,0.04965492,-0.04242244,-0.011766565,0.047446653,-0.0029992424,-0.028451396,0.10205352,0.10883185,0.0040606735,0.085261256,0.0081091095,-0.05277217,-0.025010932,-0.08925023,0.017923621,-0.0041072844,-0.041923635,-0.012321365,0.02707064,0.01080647,0.013350497,0.0089632,-0.041754678,-0.048817772,0.005990848,0.07117145,-0.025573503,-0.10556014,0.08190244,-0.017880853,-2.0844263e-33,-0.005494701,0.001403128,0.07580712,-0.01437163,-0.05641513,0.022747828,0.074469864,-0.017304633,-0.021764055,-0.070707135,0.00019783244,-0.04150775,-0.04323935,-0.04451528,0.042021066,-0.00159573,-0.06808531,-0.06031353,0.04335674,-0.01549693,-0.07070277,0.05888097,0.046577264,0.057379972,0.029562067,-0.0015271654,-0.028511766,0.038316004,-0.042753644,0.057947237,0.0015105747,0.009431169,0.0005955377,-0.027073238,-0.052853238,-0.0047512157,-0.08208389,0.0103923865,0.056211147,-0.05143856,0.07008888,0.0077443565,0.018012783,0.08913567,0.026505586,0.092176475,-0.015451187,0.04974237,-0.066207856,0.041479446,-0.02648866,0.035950374,0.030045278,-0.06670713,0.053958055,0.06516159,0.084461175,0.04950014,0.07720403,0.03264527,-0.0151227815,-0.040599577,-0.03089832,0.08740555,-0.008256097,0.10025885,-0.061091717,0.025959712,-0.003984723,0.041223153,0.074264854,0.019502236,0.051178087,0.029389948,0.017020706,-0.04292858,0.039116107,-0.006881721,0.0073555848,-0.06521029,-0.095843196,0.07136433,-0.0641415,-0.052110486,0.014901618,0.02803949,-0.0005029435,0.06965725,0.012028459,-0.0060950797,0.083578974,-0.03360532,-0.007049474,-0.0001574648,-0.000118791664,-3.945844e-08,0.102123864,-0.011884156,0.08722394,-0.070158705,-0.006481145,0.046761032,0.075498946,0.09079901,0.031109234,0.01176213,0.019564606,0.0030602233,-0.023123113,-0.012537138,-0.014049225,0.11379572,-0.03282883,0.07937196,0.008504649,-0.061432645,0.009885384,-0.04030373,-0.075097516,0.058880515,0.03170311,-0.052635532,-0.07193873,0.09298403,-0.033176467,-0.11789872,0.03162409,0.016159195,0.023104524,-0.032868907,-0.102728,0.07957816,-0.078059874,0.008136602,-0.030147865,0.0033987334,-0.07191938,-0.02977411,0.043025628,-0.042517655,-0.006961965,0.056517806,0.09932033,0.061806314,0.022690305,-0.037283093,-0.040044032,0.02958514,0.07796566,-0.051078703,-0.079178475,0.006118507,-0.060951523,-0.043654263,-0.0183625,0.0027785536,-0.032139577,0.0011113482,0.08794147,-0.051006913 +5.6.1.4,"Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyse ATP and are involved in organelle movement. This enzyme is similar to EC 5.6.1.3, plus-end-directed kinesin ATPase, but the organization of the different domains differs, resulting in movement in the opposite direction along the microtubules.",384,1.0,-0.09097491,-0.07049242,0.027928665,-0.072667606,0.027616937,0.067283794,-0.03910762,0.023873001,0.07938539,0.05085009,0.059905622,0.023418445,0.016262509,0.002896298,-0.0340937,-0.039403547,-0.0756272,0.08994872,-0.122134626,-0.043869667,0.028612912,0.05205732,-0.0072427304,0.02958016,-0.024115168,-0.004883532,0.022131424,0.003438975,-0.006563875,-0.04513857,-0.047427278,-0.041494638,-0.13226528,-0.03256041,0.03856883,0.10356342,0.024915155,-0.09402378,-0.020651693,-0.019276176,0.12720674,-0.058461033,0.055810362,-0.067842074,-0.008536795,0.05273438,0.00085348205,-0.039771438,0.07091894,0.010810134,-0.043609377,-0.1287682,0.01824716,-0.01634015,0.00918593,0.026344351,-0.0088163605,0.043466747,0.03422852,-0.02043381,0.07245075,-0.006012164,0.060807064,0.0043800264,-0.042970307,-0.060153548,-0.02994609,-0.005496399,-0.015468191,-0.01844922,-0.0017469741,-0.084041096,-0.06155482,0.123072,0.01794544,0.026230397,-0.056005828,0.014057613,-0.0038638792,-0.039391633,-0.049794123,-0.05786177,0.07592331,0.038499545,-0.019245233,0.04204812,0.029326987,0.016681308,0.03848443,0.02008474,-0.005652713,-0.049480006,0.03453033,-0.09103309,-0.015570412,-0.04366162,0.0035691455,0.0081008645,-0.013299098,-0.0016010575,0.011059402,0.08814217,0.008565851,0.0069979704,0.0015451348,-0.0047299326,-0.033368494,0.012430592,0.039490756,-0.01850109,-0.04522169,-0.028632488,0.03840309,0.068352185,0.0024614956,0.0052016755,-0.0005829804,0.04164647,0.05550491,0.026508864,-0.005396416,0.0052833557,-0.006779256,0.08422076,-0.044783812,-0.019549288,-0.13001215,-3.8348109e-34,0.021825058,-0.08815996,0.063780464,-0.0059395195,-0.023433425,-0.0405023,-0.12697162,-0.010617095,0.06785912,-0.032256152,-0.116169125,0.0065278895,0.03972473,0.024167947,-0.027976537,-0.10843158,-0.028280284,-0.022395225,0.05707758,-0.012162909,0.04271614,0.09507512,0.00076907873,0.012506216,0.011706277,-0.012957228,-0.06608688,-0.0038355887,0.029017802,-0.012406614,-0.039183863,-0.078094944,-0.10415335,0.0090898415,-0.04123367,0.038003538,0.01167621,-0.0707077,0.028726831,0.0054182676,-0.03465445,-0.056687664,-0.0670144,-0.09811271,0.012485126,0.000952286,0.010699825,-0.01589754,0.009754437,-0.039020915,0.04579611,-0.04109224,0.09516722,-0.040922105,-0.010899959,-0.016372751,-0.017311467,0.045897186,-0.029673358,0.058720548,0.094933584,0.044624783,0.0080230255,0.015507817,0.009085084,0.03129428,-0.015066367,0.03194897,0.04629003,-0.0065135155,-0.050655913,0.08320944,0.0943059,0.014004257,0.096812375,-0.021723041,-0.06947436,-0.05358123,-0.08990794,0.027347105,-0.021593746,-0.04852082,-0.011108589,0.012332804,0.008656368,-0.0068358635,0.0072923778,-0.016297191,-0.048477642,0.011692502,0.06780494,-0.021162195,-0.10493209,0.10463991,-0.022685172,-1.7112577e-33,-0.016182832,-0.016973939,0.09080716,0.023956537,-0.04627305,0.021720514,0.08079566,0.0135338465,0.010852759,-0.06373852,0.023128,-0.06630401,-0.007504102,-0.042739533,0.06277766,0.009796063,-0.0720639,-0.07670554,0.079436444,0.007337148,-0.094123736,0.028172353,0.05621236,0.047387734,0.06698839,0.012182888,-0.033066303,0.042764183,-0.035425417,0.060400367,-0.01676969,0.0038663973,0.029943932,-0.041878983,-0.05293047,-0.012601975,-0.07177843,0.02814596,0.051197305,-0.07680901,0.05641404,0.019973721,0.023195202,0.101256,0.027374737,0.07782625,-0.017908596,0.049858723,-0.07307184,0.036824152,-0.054376185,0.05768686,0.017984683,-0.056871038,0.0133096995,0.034072723,0.060425755,0.07051844,0.04233666,0.04712913,-0.0055684824,-0.035550732,-0.013385373,0.095049106,-0.0009844596,0.13086607,-0.05329494,0.0066192844,-0.00091068953,0.027670754,0.103667706,0.0071774814,0.066847645,0.05026509,0.061718244,-0.049404893,0.012950458,-0.0083092,-0.0025934374,-0.07258186,-0.088789515,0.064508855,-0.03277955,-0.04907901,-0.026263602,-0.0002741688,-0.015129835,0.080148876,0.0019570051,-0.0019597176,0.074832484,-0.037053492,0.007847687,0.033889282,-0.0053185984,-3.5274343e-08,0.08244211,-0.042545635,0.09027485,-0.07636451,-0.004739179,0.034149256,0.053081542,0.06785468,0.018593762,0.0031542561,0.005140318,0.006048356,-0.020059625,0.0027032767,0.0027570266,0.08060959,-0.05471229,0.06293796,0.009260484,-0.037942387,0.02157181,-0.03349828,-0.050315876,0.055461086,0.027025286,-0.03909427,-0.08709594,0.07866733,-0.022894423,-0.117274,0.021471823,0.0074041267,0.03518083,-0.038176864,-0.09726977,0.104056515,-0.069846794,-0.004667665,-0.006336098,5.7932735e-05,-0.09339675,-0.016219899,-0.0034238696,-0.06577364,-0.001548792,0.034648318,0.11705505,0.027388189,0.013113549,-0.06294129,-0.023135182,0.014213186,0.06591334,-0.02655522,-0.07665039,0.027534911,-0.04852464,-0.06311673,-0.014201227,-0.0046054325,-0.03224004,-0.03058896,0.1252244,-0.048531387 +5.6.1.5,"Belongs to the AAA-type superfamily and, like EC 5.6.1.4 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.",384,1.0,-0.03979627,-0.08240155,0.0073890714,-0.039854918,0.06600636,0.07943198,0.006169173,0.035829287,0.056996472,0.061303437,0.07315109,0.03544729,-0.027172018,0.050057407,0.020883007,-0.06806337,-0.12911949,0.0038385065,-0.06430617,-0.10228674,0.08041593,0.036377873,0.021145979,-0.00010472404,-0.003618959,-0.04242408,0.07248222,0.002561553,0.0150994295,-0.048355125,-0.033240367,-0.0056074494,-0.04592002,-0.0027085503,0.094333045,0.06342374,-0.08176969,-0.023809822,-0.006721931,-0.026100727,0.12053876,-0.054647144,0.012305988,-0.03167751,-0.029269425,0.052594792,0.016004838,0.030349156,0.031965867,0.07397376,0.036206346,-0.10733384,-0.0049360907,0.024505576,0.045420494,0.027140634,-0.08651716,-0.02843741,0.03702292,-0.020848269,0.03974566,-0.006404309,-0.012670087,-0.010577871,-0.0057622576,-0.047830824,0.022912242,0.047120158,-0.0028784687,0.0004815819,-0.038343564,-0.052880958,0.0018422186,0.06871261,0.034273025,0.04358885,-0.029141355,-0.08261373,-0.03893292,-0.051762592,0.011872063,-0.016035961,0.065735884,0.02153933,0.025543435,-0.0012007606,0.08070869,-0.045926657,0.0033427041,0.02470769,-0.07362284,-0.07173141,0.014552887,-0.042488456,-0.080507256,-0.005098094,-0.07126446,0.003942411,-0.02763925,-0.0066205007,0.02587947,0.04112405,0.07481216,-0.043869708,-0.022013927,0.008284661,-0.036672696,0.123190224,0.003616112,0.045015518,0.0015700121,-0.03993849,0.062365785,-0.017524017,0.07045748,0.10672515,-0.056281876,0.014533095,0.019124439,-0.013143611,-0.009802426,0.0043466967,0.027643306,0.075685404,-0.074849345,0.04555057,-0.09787426,1.1955227e-33,0.025863957,-0.028035007,-0.02852528,-0.0072190575,-0.023224495,0.042055663,-0.049921006,0.009360845,-0.0218453,-0.0051255487,-0.10336121,-0.06372288,0.09001868,-0.03624538,-0.05165144,-0.04692087,-0.062115755,0.0031476272,-0.0048339544,-0.0074068615,-0.008373429,0.0672913,-0.018424693,-0.025349934,-0.004618373,0.01072819,-0.041979436,-0.027492197,0.027671851,0.0010511861,-0.017575264,-0.02347905,-0.05752807,0.09140389,0.0195291,-0.055360656,0.010665107,-0.0437046,0.03313151,-0.021872103,-0.007705801,0.0070383633,-0.041614465,-0.052039992,0.05625327,-0.06858106,0.017589431,0.04722318,0.013563324,0.037771434,0.052802946,-0.018309679,0.08416559,-0.006348493,-0.075570025,-0.023946062,-0.083525226,0.0729997,-0.010609654,0.03258949,0.0572138,0.08633488,-0.046180144,0.006710392,0.024964806,0.07627689,-0.03886959,-0.046917647,0.018986061,0.015921576,-0.0703131,0.055521157,0.094183944,-0.00023257961,0.02108109,-0.005614146,-0.08797755,0.021984955,-0.048238333,0.081546605,-0.06502315,0.040339377,-0.051695783,0.07569435,-0.025940575,-0.03278038,-0.02263711,-0.07445667,-0.021077406,0.007080726,0.1108605,-0.040936474,-0.05546097,0.14836343,-0.023975423,-2.3898384e-33,0.01375077,-0.032551073,0.08990792,-0.05721434,-0.011745505,-0.020647755,0.09869328,-0.031002333,-0.0406441,-0.088884935,0.06487403,-0.007828254,-0.04359472,-0.01995346,0.035533134,-0.044346705,-0.1382968,0.028766055,0.09312906,0.057683606,0.020480767,-0.0004999449,0.031682823,0.039614633,0.029084288,0.058826987,0.061402638,0.03237423,0.09913897,0.044893675,-0.040583614,0.088297024,-0.022399912,-0.016423868,-0.0949359,0.028834118,-0.035060603,0.011700277,-0.014259985,-0.07842,0.04068174,0.08667861,-0.013965078,0.014883069,0.037006073,0.09041775,0.06016998,0.054349516,-0.056776892,-0.040573012,-0.063831665,0.01169098,-0.026083756,-0.008100747,-0.020350458,0.050542302,0.058484044,0.056080192,0.025581734,0.020053443,-0.019467723,-0.022929255,0.02116133,0.0331187,0.02344079,0.035291705,0.033186525,0.05759987,-0.006480501,0.0628093,0.03873199,-0.016630834,-0.087227166,-0.05426922,0.01659074,-0.013042888,-0.016810386,-0.034124322,-0.009942205,-0.06434924,-0.088815786,0.09689479,-0.09877566,-0.00062998553,0.051463515,-0.010334547,0.0053623714,0.07196835,0.013659189,0.061624326,0.021327542,-0.062242147,0.0061143725,0.07169709,0.0056997463,-3.6503575e-08,0.06725786,-0.022922836,0.034430824,-0.07821206,0.04809336,-0.00029333882,-0.002733591,0.076335244,0.011298463,-0.0038596743,0.026331602,0.004024306,0.00048849353,-0.012105286,0.068311855,0.023454823,-0.07578541,0.084052086,-0.048492767,-0.039957322,-0.0040127914,-0.07352103,-0.089884855,0.0886516,-0.033957835,-0.06546738,0.031197133,0.086278416,-0.0777012,-0.10405446,-0.017984899,0.046170335,-0.020916203,-0.04567126,-0.02165207,0.07931609,-0.02972765,0.012610974,-0.057229836,0.012584206,-0.05805481,-0.07642892,-0.0006623423,-0.019694384,0.046004135,0.04104892,0.053574298,-0.053443234,-0.008570686,-0.014867268,-0.09299998,0.009986965,0.016386228,-0.06221248,-0.07521874,0.0022398774,-0.073925495,-0.09699892,-0.02937981,-0.028447697,0.024043664,0.0048445337,0.09253295,-0.11018483 +5.6.1.6,"ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. The enzyme is found in animals, and in humans its absence brings about cystic fibrosis. Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis. Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The enzyme is also involved in the functioning of other transmembrane channels.",384,1.0,-0.038819373,-0.050277777,0.0039585326,-0.007122997,-0.11805123,0.03016969,0.04518755,0.049479857,0.06439858,-0.046909504,-0.000113545335,-0.048764024,-0.0006262403,0.12393552,-0.052929554,-0.044375233,-0.08155884,-0.020926304,0.010327555,-0.039248303,0.039323263,0.07175474,-0.057304617,0.0053766808,-0.09143593,0.018695083,0.04531444,-0.010948664,-0.0175606,-0.016484633,-0.14602578,0.007073675,0.046907548,0.024630375,0.020515995,0.071231596,-0.075851455,9.121162e-05,0.037902564,0.023931054,0.08616961,-0.007948526,0.106053494,0.09706256,-0.08679483,-0.006501256,0.024285823,0.0034957877,-0.0066481447,0.016957426,-0.016857939,-0.038112722,-0.029739605,0.052310392,-0.039624654,0.011200291,-0.06683467,0.0046574776,-0.0127611235,-0.009006594,0.019470586,0.047460727,0.014783315,0.10033583,0.038681686,-0.01206948,-0.001524919,-0.0236534,0.0022302535,-0.10549491,-0.09482277,-0.1155621,0.0046420125,0.02230713,0.07290753,-0.046850283,-0.005968629,-0.06157022,-0.051369138,-0.0066620843,0.00949259,-0.04035361,-0.037777904,0.0038870997,0.052354597,-0.028920526,0.06838145,-0.02064463,-0.0017829335,0.040349882,-0.03452051,-0.0035306537,-0.013216391,-0.02553839,-0.08396046,0.0022086147,0.01634932,0.051463753,-0.003739338,-0.018195745,0.06680724,0.06559587,0.07257027,0.004405508,0.027538937,0.002153928,0.02823065,0.03908583,0.022547811,0.0065921512,-0.061223146,0.036592077,0.009757843,-0.06707049,0.012214161,0.09452435,-0.034655094,0.020359771,-0.01896097,0.051691808,-0.010614253,-0.13134286,-0.013806174,0.013642669,0.021250851,0.048413817,-0.10172445,6.4432643e-34,-0.0448627,-0.08513109,0.052516177,0.024954936,-0.069490165,-0.00017542645,-0.013867041,-0.040779456,-0.04383262,-0.06746108,0.021812862,-0.008644666,0.002331854,0.027293779,-0.032831136,-0.050265606,-0.08467678,-0.008706439,0.042309597,0.00073236215,0.04188473,0.069081776,0.003451425,-0.08124101,0.07455137,-0.024355069,-0.03297342,0.04160561,0.098652475,0.011188525,0.008401802,-0.05951602,-0.102585085,0.007826509,-0.012851252,-0.042325627,-0.016228177,0.04343472,0.0900952,-0.0075283395,-0.07489649,-0.05708718,-0.010213263,-0.015823781,0.06955341,-0.056338467,-0.06338205,0.07450979,-0.04557644,0.014930171,0.10457187,-0.10734924,0.03628704,-0.044649955,0.024451915,-0.023374988,-0.030244203,0.062168356,-0.10414014,0.08177392,0.113878846,0.116173364,-0.052024692,0.008884285,-0.035269722,0.034744903,-0.04322607,-0.08513696,0.017225292,0.063166484,-0.0525043,0.031036587,0.04297737,0.023553072,0.020079512,0.008295646,0.002575845,0.030573243,-0.0067246435,0.03841167,-0.008199067,-0.051208463,0.07608179,0.09119649,-0.06908721,-0.034512475,0.014188016,-0.032298356,0.00933754,-0.062034126,0.11978795,0.07633738,-0.053240545,0.056535017,0.09977279,-2.1975013e-33,0.021037092,-0.035041165,0.049448706,-0.09668039,-0.031780206,-0.0300016,0.035271235,-0.02617842,0.0071236617,-0.047012426,0.01648443,0.031773746,-0.05847458,-0.0584057,-0.023215802,-0.036427595,-0.025676064,0.0032067348,-0.021211958,-0.0028076381,-0.015035902,0.045995988,0.045028087,0.028392127,-0.07797001,0.014291293,-0.040767368,0.07493474,0.042831592,0.04259304,-0.026283732,0.035398647,-0.008759395,-0.02331013,-0.1002715,-0.0030750267,-0.03945117,0.020944271,-0.012953682,-0.031680405,0.032517046,0.05649398,0.020552568,0.0033772064,0.012499722,0.14587443,0.07826993,-0.040666603,-0.003947672,-0.012732506,0.002935659,0.018903518,-0.012816479,-0.008809762,0.026982184,0.09963324,0.019530777,-0.008114013,0.0270191,-0.08407509,-0.051102035,-0.022855986,0.06977316,-0.086231984,-0.0036960833,-0.047942627,-0.009654869,-0.023788374,-0.009184246,0.06641019,0.087630525,0.06560467,-0.07393336,-0.019825285,0.0060371542,0.07499014,0.01040818,-0.044585135,-0.07032197,0.0037441812,-0.023414131,0.103434585,-0.049388718,0.0016363271,0.032144878,0.01469816,-0.002990324,-0.019121742,-0.008779082,0.03677265,0.017956024,0.012661569,-0.03032326,0.06418758,0.0094182845,-3.778472e-08,-0.019200671,-0.04303499,-0.011767566,-0.10106811,-0.0032487821,0.109818295,-0.009791077,0.025717257,0.118659295,-0.015335029,-0.032583136,0.05551565,0.037755538,0.07166252,0.08397286,0.054953363,-0.07513228,0.0048683714,3.2564614e-05,-0.03867777,-0.0541427,-0.0797963,-0.068394035,0.09444352,-0.01305051,-0.06379242,0.0020679303,0.051164944,-0.06819543,-0.04673008,0.006236032,0.025123877,-0.018662699,-0.01720222,-0.036160685,0.030959921,-0.016219588,-0.010732191,-0.11860707,0.091483794,0.06005239,-0.06690835,-0.056094263,0.022998521,0.0837668,0.034713794,0.015229954,0.033384707,0.021991817,-0.006888737,0.012132452,0.0023015158,-0.019040674,-0.06125708,-0.014400742,0.01611225,-0.05454691,-0.033351857,0.005265836,-0.02024025,-0.02424064,0.021305446,0.12056038,-0.017389458 +5.6.1.7,"Multisubunit proteins with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or entry into mitochondria and chloroplasts. Molecular masses of subunits ranges from 10-90 kDa. They are a subclass of molecular chaperones that are related to EC 5.6.1.5 (proteasome ATPase).",384,1.0,-0.008446433,-0.095160976,0.024799896,-0.029953228,0.023521595,-0.012460222,0.013297733,0.06593529,0.03773605,-0.0032638905,0.02921815,-0.086686514,-0.06575536,0.047540374,-0.016004115,0.011640824,-0.09031233,0.020227026,0.01224773,-0.061899126,0.13231237,0.012726476,0.0013759958,-0.0011798973,-0.05314827,0.010937663,0.00522366,0.029369086,0.0036561955,-0.065581076,-0.034797225,-0.002997211,0.002264107,0.02188932,0.062044032,0.044566616,-0.095075786,-0.040742736,0.0093407305,0.011263238,0.14307718,0.0457262,0.036969353,0.013176011,-0.014544051,-0.014165906,-0.02119654,0.028847791,0.09441143,0.007858557,0.089098774,-0.07971333,-0.053950712,0.12195612,0.042344317,-0.0072180154,-0.11985424,-0.009234007,0.057692323,-0.03551578,0.044146873,0.010923386,0.036991388,0.009198713,0.086800754,-0.00660658,-0.012135873,-0.03564736,-0.034815405,0.0076173097,0.013962089,-0.014463734,-0.02913038,0.1345515,0.051240195,-0.015673073,-0.08550275,-0.057983913,-0.049919724,-0.025671838,-0.013763217,0.021712404,0.0733332,0.046227712,0.06812742,-0.074173205,0.08080784,0.017523162,0.02608362,0.0065909233,0.00902842,-0.024599163,0.03304082,0.013750138,-0.09620342,0.021248793,-0.003512674,0.05167053,0.0031979159,-0.016544228,0.083820194,0.04627647,0.07984863,-0.036246963,0.03960943,-0.00025621074,-0.040312555,0.04868259,0.027271386,-0.0037748765,0.0119363945,-0.012388232,0.011054864,-0.038365975,0.04601176,0.05762591,0.0022962263,0.012590192,-0.0047625955,-0.008314192,-0.04854483,-0.051727936,0.042315345,-0.008940442,-0.054287344,0.060026348,-0.19609548,3.360143e-33,0.0122803515,-0.09698986,0.044573847,0.100950025,-0.02438743,-0.05804004,-0.01731768,-0.022461716,-0.035949167,-0.030111693,-0.051646356,-0.0050173537,0.083341606,-0.007132153,-0.020189626,-0.08438316,-0.025907394,0.046026558,0.014827361,-0.010763471,-0.0385649,0.10102653,0.04587574,-0.045872454,0.095030375,0.0031517022,-0.019603219,-0.007594889,0.05050584,0.010417052,-0.017220538,-0.1397744,-0.11451848,0.056052767,0.0043329094,-0.026489954,-0.042989418,-0.07867065,-0.004898712,-0.019720303,-0.021816742,-0.010036512,0.029423987,-0.10301487,0.051752135,-0.057072908,0.05104254,-0.008127448,-0.072001986,-0.017741965,0.029955775,-0.01823944,0.045823652,-0.024919992,-0.07975629,0.032480657,0.020252319,0.044887494,0.054510556,0.026556289,0.0076888725,0.049095694,-0.066248275,0.019913247,0.003686573,0.08459352,-0.12929553,-0.08195777,-0.010568397,0.0694555,-0.03328398,-0.024161901,0.07520113,0.00030260038,0.05677739,-0.007082667,-0.019592596,-0.008955337,-0.066472396,0.14607447,-0.018795762,-0.045989536,-0.0128943585,-0.0076297405,-0.12339092,-0.041917108,0.056284662,-0.06841398,-0.0042746,0.003404051,0.09377757,0.009521452,-0.035758097,0.010582435,-0.031847294,-4.233395e-33,0.04773954,-0.06249612,0.04072425,-0.06444826,-0.034721613,0.048053164,-0.02118959,-0.00907842,-0.08720938,-0.08642603,0.07132074,0.0050862175,-0.0094363,-0.08805196,0.045956578,0.0024345415,-0.03130343,0.049546264,0.0036667911,-0.02544499,0.009998599,0.045436352,0.08613828,0.06253633,-0.008524835,0.011714809,0.006517675,0.007046918,0.052776977,0.013792654,-0.06497052,0.002752303,0.0135985715,0.08596714,-0.07738789,-0.09521714,-0.009956411,-0.0019804763,0.027875531,-0.00903377,0.0061406274,0.067893356,-0.00040155288,0.03387187,0.030086715,0.007974329,0.050066743,0.056503173,0.008211053,-0.044275235,-0.06830817,-0.078726955,-0.030505216,-0.024380011,0.02401437,0.023585819,-0.070927255,0.08278511,0.1036406,-0.023595588,-0.04630729,-0.11643351,0.079198055,0.012473121,0.016369633,0.026344627,-0.08330999,-0.045373857,-0.120037526,0.051864743,0.022254903,-0.043385945,0.019499585,-0.040819425,-0.018511476,-0.06284808,-0.013961783,0.013809855,0.033400513,-0.054049633,-0.034235217,0.010719624,-0.022389373,0.01571505,0.077197365,-0.05183351,0.0512527,0.123437375,-0.0022827126,0.007859988,0.020595836,-0.001803323,0.023583958,0.07148265,0.013340702,-4.362422e-08,0.034220364,-0.043133844,0.026547013,-0.034970853,0.014474301,0.007220981,-0.05045017,0.042180542,0.084341995,0.045555655,0.043907095,0.005956035,0.026510123,0.019258616,0.058116812,0.052643813,-0.04247546,-0.008866175,-0.011251482,-0.012833051,-0.018503487,-0.061090115,-0.04620894,0.07738844,0.03842488,0.0082837315,-0.043589905,0.057556044,-0.08135259,-0.10299722,-0.010620145,0.03310498,-0.048153847,-0.016110092,-0.0051291273,0.07900241,-0.0365005,0.020889478,0.011604001,0.010509836,-0.011189225,-0.06506434,-0.022826785,0.020312697,0.045087572,0.056703936,-0.011475603,0.071020134,-0.04724856,-0.020052014,-0.03604178,-0.024778193,0.029094875,-0.048832193,-0.089677766,-0.0078388555,-0.05713365,-0.021934023,0.0075756595,-0.019669268,0.03958823,-0.02360956,0.07407743,-0.01666114 +5.6.1.8,Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15--27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction.,384,0.99999994,-0.06053455,-0.07270649,-0.021192979,-0.032879192,-0.09787869,-0.021848895,0.061256424,0.098352976,0.076435566,0.009518617,0.07525045,-0.015932886,-0.036987856,0.086593896,0.0058381455,-0.0071110595,-0.022020865,0.074310176,-0.022274626,-0.06618465,0.11686359,0.07773092,0.035335947,0.027024603,-0.028006516,-0.041745253,0.043446727,0.07374691,-0.005235844,-0.096489035,-0.0798601,-0.069429815,-0.04685289,0.023465961,0.07310236,0.110932186,-0.020938078,-0.08263705,0.022012208,-0.04147323,0.068027236,0.015918408,0.08615462,0.015189306,0.058465127,0.07033337,-0.028056888,0.017180167,-0.0024139707,0.06538909,0.010684772,-0.07358821,0.029078208,0.06133486,0.010111097,0.0199127,-0.11102824,0.024293993,0.0069345743,0.0013413184,0.056156814,0.02962603,-0.026559863,0.03133493,-0.0018095279,-0.04669773,0.005883161,0.050374825,0.0021215263,0.022213893,0.015886752,-0.052118573,0.0068187728,0.037787672,0.021015014,-0.082518466,-0.050955925,0.0020035875,0.027495338,-0.04216434,-0.000927227,-0.012602019,0.008379683,0.06095806,0.021231739,-0.002201792,0.05794229,0.0696816,-0.0691619,0.032473106,0.0112084,-0.012381735,-0.005426457,-0.032704063,-0.008835072,0.017989796,0.02896549,0.011269081,-0.041168075,0.0045115543,0.06903723,-0.0029171063,0.047393482,0.0060703172,0.012260313,0.024891956,-0.049029697,0.011869481,0.008642183,0.09399317,-0.013577868,0.00038900942,-0.014441181,-0.043846704,0.037149757,0.043826718,-0.014288898,0.04825373,0.009355024,0.020909194,-0.04986521,-0.08127053,-0.059630558,0.032677326,-0.074756585,0.038485587,-0.07059907,5.7343925e-34,0.055848606,-0.15432622,0.0040311543,0.011089763,-0.0737214,-0.046269704,-0.0075479434,-0.06954433,-0.052032843,-0.023008509,-0.060273964,-0.029827135,0.080915496,0.0842591,-0.043397266,-0.08572651,-0.014376503,-0.023059612,0.09681671,0.06913774,0.00035715103,0.110095285,0.0071303677,-0.037798207,-0.0028770554,-0.018888233,-0.091904595,-0.025849039,-0.010006803,-0.007373805,-0.044918053,-0.06685392,-0.061628837,0.050201736,0.05843083,0.001436196,-0.022341594,-0.05648432,0.0386079,-0.050247166,0.0027377917,-0.02170437,0.0017961805,-0.07515324,0.02663029,-0.01623315,0.03997189,-0.020466093,-0.040933866,0.02071267,0.08603268,-0.005493098,0.0940318,-0.09524513,-0.045487914,-0.017391924,-0.031039545,0.0570457,-0.01811768,0.06645547,0.028195655,0.056003075,0.022755455,0.04872585,0.0054531177,0.0633899,-0.14819796,-0.017923724,0.041480657,-0.0058607548,-0.032079436,-0.04337217,0.040485468,-0.053698245,0.06467065,0.03132712,-0.042466585,-0.007700844,-0.12392542,0.054244988,0.021059718,-0.021113668,-0.024112472,0.04496164,-0.0032958698,-0.015710482,0.060015872,-0.077243865,0.01415976,0.010818888,0.042791653,-0.038186207,-0.07254889,0.089581996,0.045025848,-2.7465988e-33,0.08038454,-0.020291345,0.11399999,-0.03378568,-0.044591457,0.00021061518,0.035450533,-0.011192671,-0.039867163,0.03955999,0.13534005,-0.027356055,-0.15925814,-0.010434494,0.03661584,0.034130257,-0.11666943,0.018685145,0.057731174,0.02465403,-0.065342285,0.0918295,0.046849314,0.08275578,-0.0162193,0.00048998947,-0.060427066,0.02366134,0.016919304,0.011292689,-0.04133286,-0.086839445,-0.077024765,-0.036422018,-0.0497869,-0.033213157,-0.032283857,0.026972624,0.041978966,-0.10000327,0.07141526,0.041324448,0.03952817,0.07223768,0.008746133,0.039008908,-0.012714433,-0.033472206,-0.14871359,-0.004362718,-0.07114904,0.013509228,0.032751005,-0.011008382,0.071436495,0.03902365,0.034527894,0.039001115,0.052942462,-0.007497304,-0.059869457,-0.08477291,0.01574257,0.03642163,0.09518512,0.049356613,-0.06099203,-0.023800105,-0.014980477,0.05693582,0.01379116,0.030697243,0.033965606,0.015885657,0.048968118,-0.04070425,0.024793722,-0.08147667,0.00089179096,-0.039315008,-0.004502896,0.025861088,-0.057504065,-0.0734758,0.05380418,0.023979846,0.020864218,0.019748256,-0.031197866,0.03033768,0.107733175,0.037291393,-0.03399829,-0.021520484,-0.0052411864,-3.363085e-08,0.054636385,-0.025243724,0.07068326,-0.12476454,-0.015318501,0.016553406,0.06807471,0.058644973,0.064117245,0.04400704,0.08145562,-0.0066569084,0.030416511,-0.040430114,-0.044935536,0.054468665,-0.07411578,0.0075568524,-0.027685408,-0.089758,-0.022739975,-0.041276053,-0.019447694,0.048078712,0.028005505,-0.03404254,0.002412328,0.05936293,0.015753148,-0.043587532,0.05065088,-0.02157385,-0.008556724,-0.052384544,-0.059464563,0.023824042,-0.064721934,-0.017028516,-0.08376817,0.03308464,-0.04528538,-0.07210556,0.009240978,0.011119949,0.02789593,0.0067101927,-0.007949354,0.010050862,0.022378074,0.054409735,-0.026408857,0.0057112016,-0.017878382,-0.020654883,-0.07818038,-0.022659102,-0.031008191,0.00823281,-0.013582421,0.008479433,-0.030563666,-0.039615463,0.045657963,-0.0500023 +5.6.2.1,"These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.2 DNA topoisomerase (ATP-hydrolysing).",384,1.0,-0.05417342,-0.03195571,-0.038002945,-0.014053096,0.026799966,-0.0043440484,-0.060223103,0.066552736,-0.045014784,-0.0619759,0.08754943,0.056131534,-0.05604593,-0.015211166,-0.052643187,0.03487458,-0.108949274,0.06399048,-0.037876934,-0.065937534,0.07457061,0.036919285,-0.012552288,-0.037629828,0.051187616,0.06796028,-0.04113361,0.03782179,0.04637769,-0.037472337,-0.0042954125,-0.0060119564,-0.049073495,-0.014609773,0.107336976,0.10397308,-0.014112261,0.08331499,0.0408739,-0.026611503,0.10882295,-0.016718676,0.011619262,0.031723622,-0.06985522,0.006120211,-0.012470057,0.031253163,-0.032411102,0.013144811,-0.05366518,-0.013395869,-0.07728986,-0.038471125,0.024210472,0.15079196,-0.009593328,-0.029608417,-0.01064332,0.009068633,0.08359227,-0.014906802,-0.023485662,0.048598144,0.12481243,-0.08218629,0.12532951,0.06502035,-0.014365198,-0.00765366,-0.030373147,-0.03793972,-0.049417373,-0.012715064,0.016883742,-0.042462572,-0.081462726,-0.0568925,0.012038436,0.0727071,-0.043897834,-0.06404797,0.05700664,0.016713357,-0.027402237,-0.05479776,0.08311816,-0.0051115095,-0.058937084,0.050901353,-0.021898074,-0.07205865,-0.026294962,-0.046957664,-0.052946016,0.04715708,-0.011145337,0.05771691,0.03368881,-0.034510616,0.044831026,-0.08974305,-0.040154055,-0.075990885,-0.0013912201,-0.00081138057,-0.003180947,0.03386286,0.060762063,0.0036756466,-0.04396809,-0.05424494,0.049043197,-0.056347523,-0.08384295,0.068737,-0.018528217,0.015113591,0.056089703,0.01805038,0.0063247895,-0.02671485,0.10343191,-0.009675776,-0.043088105,0.022888914,-0.01870485,3.3228537e-34,0.010344276,-0.0069719725,0.030527363,0.03282046,-0.07203482,-0.029768338,-0.096272774,-0.012692438,-0.09947492,0.083315104,0.012425165,0.03704857,0.03247515,-0.030635238,-0.0189361,-0.048607364,0.0041476423,-0.0022642582,-0.029284993,-0.031891976,-0.003021228,0.087475285,-0.031816386,-0.0072743334,-0.0071249986,-0.003391145,-0.011199041,-0.008068694,0.10429751,-0.0037209454,-0.0054194615,-0.0042188712,-0.061406594,0.08905863,0.056198444,0.084439956,0.03866193,-0.03891166,0.022957556,0.022434106,-0.047599435,-0.005335225,0.04608456,-0.09743166,0.08058811,0.0024690193,0.012417461,0.037529156,-0.03128711,-0.024979824,0.010713934,-0.082012236,0.06702346,0.0034875541,-0.048696574,0.0016615205,-0.006071365,0.02241614,0.0054128575,0.08317208,-0.023480233,-0.02935224,-0.034561843,-0.049484845,0.048629623,0.034665346,-0.039251145,-0.047852986,0.019228326,0.089038655,-0.11807557,0.045384638,0.009427954,0.0012961457,0.037339922,0.015100741,-0.07789058,-0.03625451,-0.051176753,0.018945983,-0.03348163,0.03024337,0.0135176545,-0.024608567,-0.014747159,-0.018700073,-0.04817564,-0.038373787,0.05031806,0.04863094,0.082680255,-0.034164228,0.03996952,-0.006789847,0.039382897,-1.5082027e-33,0.06892448,-0.07768072,0.019551234,0.030706082,0.010531962,0.024184268,0.012018977,-0.00041539507,-0.035446182,-0.012704143,0.046201665,-0.013224803,-0.0342636,-0.09762857,-0.044054072,-0.062331904,0.04994367,0.053794663,0.009071635,0.016150275,0.014573809,0.03122235,0.009464968,0.022044944,0.034478884,0.032262128,-0.012873086,0.05314782,0.095173426,0.05118043,-0.0838834,-0.040980875,-0.02032809,0.04021311,-0.09917783,0.10256573,-0.009476439,0.06500054,-0.010554334,-0.005035382,-0.036049563,0.05988074,-0.032775544,0.04204644,0.048515897,0.028013341,-0.12772322,0.029542547,-0.08283198,-0.06411424,0.043432243,0.051565118,-0.07417994,-0.056719046,-0.0017236066,0.028902652,-0.04325826,-0.056429733,-0.0066343937,-0.008063954,0.0066162837,-0.09391398,0.01806991,-0.028994186,0.04630433,0.015924418,-0.06325647,0.010409289,-0.12528493,0.020953115,0.008298985,0.00038715027,0.021013806,0.024931584,0.08416017,-0.03882681,-0.0096918745,-0.07456591,0.005505478,-0.069743864,-0.019183833,0.011863762,-0.059670836,-0.054141358,0.11974445,-0.046785813,0.05802142,0.069379814,0.009324065,-0.027706133,-0.028624393,-0.0061391317,-0.023828646,0.0498714,0.0036593587,-3.8469445e-08,0.029839667,-0.0891418,0.031067893,-0.036944933,-0.015428172,0.08745528,0.051858608,0.0519138,0.14262095,-0.0068945177,-0.010740984,0.10338018,-0.031091519,0.011534615,0.04265032,0.04413341,-0.08617313,0.03790662,-0.023477944,-0.02126627,-0.10169228,0.0015029281,-0.11068863,0.04543986,-0.015057836,-0.028331693,0.073908314,0.057694938,0.01863754,-0.06385229,-0.038510095,-0.003775687,0.03379238,-0.009841922,-0.07576178,0.060178194,-0.066496216,0.029892636,-0.03515311,-0.00044789902,0.08840295,-0.01835305,-0.09672881,0.03181609,0.08097592,-0.043662682,0.085245036,0.050614644,0.0060052145,0.02867448,0.0038097345,0.008589372,0.011591236,-0.085384436,-0.013843064,0.015690982,0.047648847,0.03614135,-0.032150555,0.018618817,-0.0024542178,-0.028883368,0.13334154,-0.017892424 +5.6.2.2,"The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.6.2.1 DNA topoisomerase).",384,1.0,-0.05829086,-0.049718134,-0.043811284,-0.022508582,0.022342842,-0.03240475,-0.08615506,0.11414711,-0.0065230904,0.021339562,0.09714227,0.04255211,-0.041692287,0.032904956,-0.045047414,0.041667745,-0.07601127,0.005988156,0.0075412714,-0.07107965,0.12601672,-0.030910566,-0.00032992332,-0.031179238,-0.01595727,0.0894325,-0.0150161525,-0.003344902,-0.015059469,-0.087039225,-0.020382274,0.009232453,-0.081839964,-0.021846538,0.08399933,0.07906527,-0.03750046,0.12966807,0.025989845,-0.025527803,0.08998805,-0.007371957,-0.029565059,0.03381332,-0.05767641,0.00403705,-0.03647963,0.056155954,0.028071001,0.040529273,-0.056778345,0.005780294,-0.015994726,-0.029599583,0.04648716,0.11929393,-0.03400533,-0.005155617,-0.03651735,0.021925528,0.06469437,-0.051986046,-0.029126864,-0.037500888,0.14198525,-0.062658414,0.046779055,-0.027946366,-0.042693432,0.03046965,0.044968717,-0.06845883,0.0069549447,-0.030448101,0.046126448,0.03432948,-0.08491854,-0.06667965,0.039818656,0.09091548,-0.009797046,-0.049462967,0.090815105,0.04622222,0.023300722,-0.01596008,0.16171397,0.001663942,-0.04236619,0.086595125,-0.046680726,-0.07063748,-0.025455508,-0.06681894,-0.072684094,0.062590145,-0.043715205,0.03381776,-0.035102952,-0.04089254,0.045990147,-0.072928734,0.011523918,-0.077759154,-0.0060277865,-0.008144903,0.014261112,0.027801514,0.06729661,0.03457414,-0.017640984,-0.00014291765,0.036488526,-0.06331909,-0.08380245,0.06606672,0.024862224,0.03724844,-0.08963087,-0.031256158,0.020555897,-0.014564693,0.028678088,0.02805902,-0.016488694,0.0900566,-0.055508956,7.6356518e-34,0.015118482,0.026488274,0.046639524,-0.023902494,-0.06627885,-0.068184756,-0.09125924,0.04436218,-0.088784635,0.05243197,0.04924665,0.008795827,0.05478874,0.0059753377,-0.054015722,-0.057440177,-0.003440387,-0.033405475,0.010369512,-0.033477616,0.025286287,0.040819056,-0.014695043,-0.033464514,0.012384364,0.0062000905,0.0007218526,0.012312313,0.0795434,-0.0033183456,-0.0061828,-0.057031557,-0.042684447,0.091413155,0.047563426,0.055679522,-0.02801606,-0.051494297,-0.00023609347,0.034776192,-0.093221225,0.024093613,0.04640067,-0.12509099,0.034646593,-0.02322283,0.041095976,0.027146626,-0.039824996,-0.0023944364,0.04714418,-0.07069447,0.03815248,0.037654307,-0.0022640969,0.040679846,0.004895602,0.027414655,-0.0022074066,0.019978922,0.032103933,-0.069903605,-0.060392886,-0.055643428,0.01598001,-0.0039080535,-0.044738468,-0.043090794,0.06045919,0.0504096,-0.07768247,0.039386917,0.04914638,0.020135378,0.015484817,0.048298452,-0.019642672,-0.029719105,0.04207742,0.017896255,0.0007062408,-0.0146793,0.046184424,-0.053693194,-0.041951902,-0.013485666,-0.02435183,-0.06678789,0.011846789,0.04665507,0.071066275,-0.07093102,-0.011777902,0.057221547,0.00163882,-1.431323e-33,0.013739112,-0.07515463,0.013766286,-0.03752142,-0.01785302,0.038797308,-0.0023404357,-0.035044536,-0.035905514,-0.019195419,0.06960862,-0.026498485,-0.026433894,-0.019417021,0.0468462,-0.023464713,0.056412894,0.055164114,0.037155647,-0.008903475,-0.03535996,0.091178335,-0.022439456,0.07077059,0.07717305,0.025137449,0.007887222,0.08666249,0.08544138,0.049082067,-0.08169699,0.04387818,0.038750507,0.055929698,-0.042594563,0.07846356,-0.055605017,0.0035940083,-0.002106817,-0.0297228,-0.043192424,0.071689315,0.02227545,0.083863564,0.028534476,0.00038942095,-0.07388816,0.10450232,-0.0035392581,-0.12242673,-0.018223582,0.007495444,-0.051681522,-0.007256558,0.024122197,0.018630726,0.018926444,-0.048092432,0.038486358,-0.0014147867,0.005034432,-0.059603542,-0.0072992872,-0.041261017,0.021094747,0.05660243,-0.07351616,-0.0028425094,-0.096051864,0.008063076,0.03158958,0.07068628,0.010717067,-0.0078327535,0.04793158,-0.021844642,-0.04558073,-0.052811425,-0.018542137,-0.074119404,-0.03935374,0.045458246,-0.08530611,-0.034458376,0.06565544,-0.07276965,0.047721803,0.08453774,-0.034595698,0.017898295,-0.03471347,0.04297073,-0.062524594,0.092377745,0.055319425,-3.4776527e-08,0.0085834805,-0.068691984,0.07049646,-0.021271719,0.011756094,0.030204523,0.070439786,0.034205988,0.13858995,-0.023301894,-0.038770832,0.1070284,-0.039119158,-0.02377794,0.049998924,0.06718952,-0.08106905,0.020291118,-0.022147538,-0.017905828,-0.09508588,-0.037014578,-0.12636822,0.014102131,-0.046731777,0.005622691,0.07376134,0.027678229,-0.009639003,-0.050560977,-0.025407191,-0.0043036127,0.021766054,-0.003380766,-0.091105975,0.037491433,-0.044498034,0.03936175,0.012176957,-0.0026848016,0.08937824,-0.026109003,-0.08875291,0.029227445,-0.014478635,-0.0015606576,0.0071315747,0.0007544989,-0.0023263912,0.011843326,0.0025805,-0.026175635,0.039108478,-0.05759943,-0.049452044,0.019415107,0.032272633,-0.004137165,-0.031030424,0.027571898,0.00515147,-0.041853912,0.15433642,-0.012037809 +6.3.2.53,"The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyses the ligation of a terminal L-glutamate to UDP-N-acetyl-alpha-D-muramoyl-L-alanine. The combined activity of this enzyme and EC 5.1.1.23, UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase, provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3, glutamate racemase, and EC 6.3.2.9, UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase.",384,1.0,-0.03145464,-0.051414374,-0.0023426064,-0.08008502,0.051215988,0.037564006,-0.07142456,0.03456137,0.03156492,0.03368609,0.020803528,-0.013421315,0.05836114,0.06832374,-0.00049355906,-0.018164987,-0.06607002,-0.043670688,-0.06531958,-0.022853788,0.06628687,0.06322656,-0.028302927,-0.046095695,0.055248886,0.07174559,0.07575333,-0.014983766,0.015157189,-0.10385621,0.034208797,-0.11226231,0.05821327,-0.04010134,0.02817183,0.025335072,-0.03427901,-0.008601363,0.06606731,-0.0059221615,0.011839637,0.069322914,-0.02917869,-0.060851734,-0.01761331,-0.072323255,-0.034158424,0.019310668,0.02481845,-0.008138393,0.049525455,-0.06654357,0.010051405,-0.011412799,0.019480364,0.044939924,-0.06174506,-0.0047063413,0.013347543,0.012307226,0.025436584,0.07710696,0.036581438,-0.031532157,-0.073825784,-0.07139228,0.05282028,-0.0564128,0.032259263,0.029240001,-0.076488994,-0.07132331,0.026330715,0.044237174,0.014210729,0.007722735,0.06889826,-0.029400202,0.022138003,-0.026912509,-0.006791919,0.00783059,0.07098742,0.012106025,0.03503387,-0.001934421,-0.004759983,0.023877714,0.045158144,-0.002832991,0.067037076,-0.061129775,0.035202246,-0.034814987,-0.0044001387,0.0075979945,-0.033218123,0.022655804,0.04237681,-0.007563104,-0.008855137,0.042358477,-0.053987853,-0.1016984,-0.029316518,-0.0012591473,-0.024660554,0.085675724,0.022659643,-0.06922607,0.002608985,-0.03995813,0.045671575,0.03463921,-0.07449273,0.058869004,-0.03562646,-0.03151384,-0.005315606,0.030640263,0.06392072,-0.012132077,0.041486386,0.07538148,-0.001908337,0.031256717,-0.05041813,2.1439213e-33,0.0037371193,-0.029983547,-0.03809926,-0.031336166,0.015660455,0.023714498,-0.0646832,0.08587134,0.011894048,-0.061497044,-0.04070755,-0.039100572,-0.028977802,0.03306391,-0.005186713,0.0021721404,-0.035843723,0.040732503,-0.0064256038,0.012310187,0.007743157,0.0105117485,-0.02218633,-0.0059912875,0.042967148,0.07027336,0.058088876,0.030318057,0.12672397,-0.003517224,-0.09758131,-0.09019288,-0.09349896,0.02191937,-0.03564197,0.04650995,0.007912645,-0.020806562,0.05113781,0.06621494,0.022680106,0.035395727,-0.05112872,-0.00035448643,0.037184816,0.0031126754,-0.069180764,0.067470424,-0.008795652,0.025095962,0.026800917,-0.09139222,0.0776855,0.02071554,-0.060289267,0.045945782,-0.104715236,-0.012584639,0.057864334,0.025607985,0.055931572,0.060083415,0.021751989,-0.00070511433,0.0033416902,0.0046354923,0.051359344,-0.04253711,-0.019107748,0.048606027,-0.054440398,-0.01828087,0.109067984,0.049931575,-0.023139386,-0.09772316,-0.023257032,0.04841491,0.06279527,0.031760655,-0.04695104,0.022070708,0.01629243,-0.020766879,-0.0016263648,-0.017715124,-0.023015669,-0.044176932,-0.014001111,0.09246874,-0.017721735,-0.04856066,-0.03379671,0.08718894,-0.029992966,-2.0448301e-33,0.060568612,-0.09606899,0.08270289,0.009167691,-0.107887834,0.0670997,0.0046369922,-0.036285307,0.0406868,-0.043317605,-0.0006129944,-0.002365692,0.032558348,-0.08287221,0.049916096,0.023237994,-0.014051433,0.10309695,-0.06959485,0.021271504,-0.017010698,0.0016538431,-0.0009737331,0.020669732,0.09520838,0.012576794,0.03213919,0.020530894,0.039007213,0.045002133,-0.0011342084,0.03553392,-0.054857094,-0.05040691,-0.099066176,0.088583976,0.047391985,-0.0067100357,-0.05490911,-0.018071685,0.0076793726,0.1367055,0.0068771634,0.045354623,-0.010840304,0.12181753,-0.0076363636,-0.04230042,0.011376647,-0.025290487,0.01956448,-0.026513008,-0.02195037,-0.033388484,-0.049033593,0.024185965,0.0508478,0.025599997,-0.05723181,0.0043046703,-0.021755302,-0.08157432,-0.00524668,-0.017069004,0.07193543,0.011805349,0.048334323,0.06265246,0.02797158,-0.01726441,0.036294088,-0.080421746,0.009602501,0.054349627,0.009133414,0.080437645,-0.060071483,-0.107601784,0.022063937,-0.07708286,0.016656248,-0.015267148,-0.028697202,-0.039006777,0.021491058,-0.032712545,0.031839322,0.18967418,0.040292226,0.0743062,-0.011742315,-0.06980748,0.017965116,0.06892708,0.111256935,-4.9602995e-08,0.07586396,-0.086237915,-0.03582108,-0.036706768,0.022240825,0.029051134,-0.09263244,-0.027090171,0.05753356,-0.07685619,-0.002777381,0.009789534,-0.05824475,0.040136468,-0.0667851,0.06449602,-0.03610251,0.037430003,0.0045117335,0.052668918,-0.13901155,0.016176624,-0.088415615,-0.0064028027,0.039584275,-0.079452015,0.04729217,0.12200522,-0.025780814,-0.013271822,-0.11537025,0.023052858,-0.0635063,-0.009841254,-0.03814611,0.009477015,0.0138311675,-0.00875663,-0.040175386,0.032981094,0.056162532,-0.055298846,-0.06612981,-0.01814265,0.0012878246,-0.017178955,-0.012254386,-0.00018310519,-0.03650873,-0.049729552,0.03836954,-0.010837773,0.040212426,-0.124466754,-0.11614923,0.037074756,-0.07402742,-0.09416816,0.03341089,-0.043470953,-0.010700987,-0.016227957,0.12971589,-0.020391397 +7.2.2.19,A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed.,384,1.0,0.0046793474,-0.0020911065,-0.00094679557,-0.012086233,-0.035022873,0.0076015517,0.057661,0.004252646,0.07551895,-0.022179747,0.013871726,0.026753603,-0.051507294,0.09594511,-0.018018112,-0.080392495,-0.0625964,0.025715461,0.09129026,-0.0775828,0.07030937,0.0035221544,0.025053715,0.026512763,-0.05463891,0.01406638,0.080483325,-0.0283255,-0.019212982,0.023366312,-0.13360247,-0.03393647,0.011543338,0.019527204,0.036980286,0.106580615,-0.053337343,0.054992847,0.010048771,0.00032342333,0.12520488,-0.055478074,-0.002986679,0.040475186,-0.060469456,-0.036219843,0.018766899,0.030897425,-0.04250415,-0.048946917,-0.018966177,-0.039546747,-0.10668635,-0.020252818,-0.0038751948,0.024616394,-0.06702648,-0.0027656,-0.008611747,-0.07392797,-0.023979219,0.020171834,0.011973829,0.06460049,0.0722889,-0.08449921,0.0690311,0.038036812,0.034649707,-0.023525875,-0.07031595,-0.044369083,-0.053597078,-0.008811406,-0.0110094845,-0.019515434,-0.0623978,0.01934446,0.00083715154,-0.021069184,0.08782834,-0.0037429517,-0.04011929,-0.034923155,0.0781916,0.017270796,-0.018009432,0.014168464,0.026926754,-0.06417581,-0.05212572,-0.0917833,-0.008188109,-0.004967768,-0.07902456,-0.0013774516,0.006538717,0.014393198,0.04842886,0.011768695,0.026232928,0.091320865,0.06481407,0.02299311,-0.0180051,0.018489422,-0.015814684,-0.008077429,0.046813607,0.053746928,-0.0804137,0.008276089,0.045115616,-0.04013967,0.03243192,0.08345109,-0.04150741,0.027403818,-0.0050164135,0.046816863,-0.05351383,-0.06862428,-0.02391365,0.032276046,-0.04124501,0.032464,-0.051946376,2.0063417e-33,-0.027756123,-0.02992829,0.08169763,-0.028449211,-0.016206594,-0.005300803,-0.032550927,-0.07433973,-0.042268686,-0.067571945,-0.020597516,-0.033820093,0.033290517,0.048400603,-0.03637449,-0.05331851,-0.07300464,0.078880586,0.113856584,-0.022806026,-0.008248187,0.04661751,-0.019288823,0.03139651,0.029794056,0.037073378,-0.051146936,0.01955424,0.056230165,-0.0035239388,0.03437776,-0.06141842,-0.052598838,0.0053807143,-0.07045739,-0.08496109,-0.099077284,-0.019774282,0.08525943,-0.0626404,-0.15838249,-0.08600318,-0.025122035,-0.033972964,-0.015160409,-0.049751986,-0.047808874,0.085348904,-0.0051439684,0.045357324,0.06299595,-0.082371116,0.0889172,-0.04254426,-0.07119728,0.0009002757,0.021531956,0.005748413,-0.018195024,0.018687777,0.09538987,0.1149192,-0.019018486,-0.002449388,-0.02174106,0.04729353,-0.11520722,-0.07700048,0.06352664,0.10878818,-0.0962734,0.052672442,0.005382094,0.0032395907,0.066931784,-0.017634736,0.02444298,0.008089774,-0.070436865,0.06484189,-0.03466697,-0.0775595,0.07017393,0.05043838,-0.03642875,-0.032770306,-0.03752594,-0.05538005,0.037867125,0.05420607,0.011016984,0.020848475,-0.012291623,0.13073839,0.08853448,-3.316762e-33,0.08679697,-0.030329717,0.042204574,-0.08425426,-0.031910013,0.022628201,0.033070765,-0.040328126,-0.036191396,-0.03588945,-0.020783763,0.019681137,0.0010950448,-0.05462177,0.015539192,-0.019011965,0.01927234,0.05278308,0.05114557,0.034148388,0.038880423,0.0711805,-0.014685826,0.008929775,-0.009590149,0.014364307,0.026856724,0.05588806,0.024855904,0.002104972,-0.0076055727,0.010770325,-0.027741518,-0.01528945,-0.080992304,-0.008234533,0.03785419,0.047309477,-0.011736857,0.039729264,0.0517252,0.07839519,0.088685244,0.036821064,0.03918972,0.06071002,0.037693437,-0.02227229,-0.02941943,-0.07211708,-0.0077904826,0.08376179,-0.08396297,0.029400492,0.06387265,0.08892436,0.0071958792,0.0027949607,0.004672685,-0.08571455,-0.10164879,-0.12530518,0.039372414,0.052512646,-0.004060002,-0.05274816,-0.010234319,-0.054365315,-0.030168507,0.057544198,0.057153784,0.09952737,-0.044423923,0.020533431,0.0383529,0.0045389733,-0.008941543,-0.023027452,-0.028850155,-0.026875362,-0.05416554,0.025209337,-0.04111527,-0.07685698,-0.005178793,-0.06885012,-0.023392132,0.023062635,0.03210438,0.011422337,0.026014015,-0.02954922,-0.016630985,-0.009815917,0.02620726,-3.0785056e-08,0.006946951,-0.052224956,0.034975916,-0.02332108,0.031124875,0.026862541,0.025392834,-0.0013864178,0.07799718,-0.03068424,0.010850952,0.0113581875,0.08818044,-0.010175582,0.054783586,0.05715675,-0.07084336,0.040105667,-0.019322623,-0.056996476,-0.025098044,-0.026643625,-0.10150282,0.1187923,0.06804014,-0.016707983,0.038539283,0.045423917,-0.07271354,-0.084705,0.034691714,0.036961794,0.016716382,0.018332904,-0.044748027,0.019248141,-0.029935433,0.05060191,-0.07349923,0.041030522,-0.023113219,-0.04170092,-0.017633425,0.013841782,0.04877144,0.07938807,-0.0007274571,0.006901874,-0.017099027,0.0014965136,0.043946527,0.020933108,-0.055799577,-0.10401534,-0.057958286,-0.0085262945,-0.008272854,-0.060965247,-0.008002135,-0.050943516,0.071892366,0.008138407,0.14557299,-0.050702993 +7.2.4.4,"Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. The enzyme described here is a membrane-bound biotin-dependent, Na+-translocating enzyme [6]. The other type is a biotin-independent cytosolic protein (cf. EC 4.1.1.88, biotin-independent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. Both enzymes achieve this by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-bound form of the enzyme. The ACP subunit of both enzymes differs from that found in fatty-acid biosynthesis by having phosphopantethine attached to a serine side-chain as 2-(5-triphosphoribosyl)-3-dephospho-CoA rather than as phosphopantetheine 4'-phosphate. In the anaerobic bacterium Malonomonas rubra, the components of the multienzyme complex/enzymes involved in carrying out the reactions of this enzyme are as follows: MadA (EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase), MadB (EC 7.2.4.1, carboxybiotin decarboxylase), MadC/MadD (EC 2.1.3.10, malonyl-S-ACP:biotin-protein carboxyltransferase) and MadH (EC 6.2.1.35, acetate---[acyl-carrier protein] ligase). Two other components that are involved are MadE, the acyl-carrier protein and MadF, the biotin protein. The carboxy group is lost with retention of configuration [5]. ",384,1.0,-0.057051256,-0.06804978,-0.04645431,0.021942526,-0.045638584,0.03968499,-0.07149741,0.02139641,0.034997303,-0.0777854,0.028299274,-0.028113538,-0.12590365,0.04201506,-0.06278524,-0.022676162,-0.059013274,0.00073513633,-0.007961372,-0.026703443,0.114074364,0.03474355,-0.08982845,-0.049292456,0.029914705,-0.033133265,0.029319676,0.004867951,-0.018760525,-0.07532209,0.0006671238,-0.040233307,0.05362978,0.031026538,0.017938714,0.12741491,-0.036360342,-0.051727187,0.09122487,-0.049940504,0.034196552,0.0058979024,-0.0048126243,0.04912867,-0.03346082,-0.1015768,-0.12038429,-0.000543971,0.04714854,-0.056255355,-0.04860622,0.033606894,-0.056845367,0.040942892,-0.024201605,-0.041390896,-0.0077402107,0.013775282,-0.09348927,-0.029805219,0.010140783,0.027051635,0.00040863352,-0.05985556,0.024389187,-0.026182115,0.05645624,-0.01603728,0.04277983,0.031534273,-0.06278931,-0.10773544,0.03806722,0.067356706,0.025292432,0.039138246,-0.029572774,-0.032130998,-0.06838284,0.018715387,0.047748487,0.019171892,0.03509786,0.044532303,0.010481122,-0.10869703,0.010420485,0.036960114,0.02731615,0.056356754,0.032396995,0.009553048,0.027498404,-0.045668706,0.034261692,-0.0025993674,0.018696187,-0.050559923,-0.024068087,-0.03794841,0.004812942,0.01279556,0.002327259,-0.057963017,-0.011739648,-0.016802814,0.009358547,0.04031555,0.009108245,0.028651925,-0.0085856635,0.0629874,0.05617614,0.008299551,-0.010119073,0.121549934,-0.11074551,-0.046365794,0.045015592,0.009840338,0.0054613613,-0.056635346,0.032434706,0.023361033,0.00022179994,0.05296814,-0.15142205,4.393664e-33,0.0391009,-0.03893846,-0.040837932,0.0062918086,0.007566683,-0.036954477,-0.08267438,0.05342254,-0.038848355,-0.005035092,-0.012970549,-0.05184825,0.05763287,-0.03905789,-0.007993649,-0.05432117,-0.056035068,0.0007867608,0.07999879,0.017334756,0.014332584,0.13427524,-0.011416746,0.015978843,0.030271368,-0.011448706,-0.036365155,0.0070894337,-0.013951979,-0.0028827938,-0.00010157594,-0.034460884,-0.009941387,0.0077082957,0.07622623,0.039349932,-0.018215017,0.002595662,0.017881243,0.055469725,0.11405844,0.016063454,0.02406424,-0.058141816,0.057198174,-0.051697016,-0.15504412,0.07134755,0.012523012,0.047535624,0.037215564,-0.043236684,-0.014914553,-0.001601699,-0.057295017,0.03060685,-0.11013118,0.022246074,0.060985662,0.0014043063,0.06350701,-0.0356274,-0.009139175,-0.026959956,0.0066458406,0.037456486,-0.06357604,-0.068571694,-0.008393596,0.1018655,-0.06789819,-0.04209872,0.058562197,0.044499125,0.008505617,-0.029171837,-0.062130127,0.04855503,0.02060473,0.07052895,-0.009571208,0.054194275,-0.024783395,-0.0616818,-0.03924281,-0.0025836364,-0.050655384,0.0633821,0.01912448,-0.020204188,0.039140794,0.004672414,-0.020719625,0.01592378,0.009599626,-6.876764e-33,0.12689793,-0.1407843,0.0217368,-0.050792605,-0.01588396,0.100207,0.07892098,-0.013606357,-0.038972452,-0.017659213,0.04786287,0.034462277,0.060194198,-0.056952886,0.030181615,0.06748939,-0.051075913,0.036710795,0.028606586,0.024712713,-0.047988787,0.10044789,0.019958714,0.06619662,0.00944559,-0.01159457,-0.0475588,0.12533322,0.00714851,0.043738276,0.006189479,0.04393266,-0.052399553,-0.056173295,-0.09399543,0.033923674,-0.09655991,-0.042761907,-0.048149306,0.054559648,0.04805123,0.05080121,-0.019658739,0.041880004,0.09134731,-0.017027875,-0.009576252,-0.043799017,0.05142527,-0.057319883,0.061084818,-0.00050140737,-0.02075823,0.001397444,0.024598395,0.10119455,-0.0128841065,0.02673182,0.006898851,0.03525923,-0.06293425,-0.051602434,0.053144004,-0.05765667,0.03834139,0.05547351,-0.0011883934,-0.0012472265,0.03634204,-0.04014332,0.014811903,0.03215665,0.023635257,0.0058309888,-0.012331526,-0.062925,-0.093104765,0.022300193,-0.07158402,-0.062253535,-0.031180127,0.03467134,-0.035031136,-0.040942002,-0.04814679,-0.021320878,0.018201774,0.08453004,-0.02136454,0.035793163,0.019377166,-0.06913831,-0.007888729,0.023169616,0.06411143,-5.3569735e-08,0.0825486,-0.0048026503,0.019919565,-0.009740673,-0.034845103,0.028939925,-0.014065129,-0.04733935,0.003075415,-0.03577955,-0.04852945,0.036710583,-0.07883456,0.09461199,0.012680013,0.053707242,-0.11756903,0.0710843,-0.02307885,-0.04334749,-0.061560698,-0.017711213,-0.09554691,0.09637616,-0.024832388,0.024103226,0.022008024,0.0026652464,0.016281428,-0.020775668,-0.044040546,0.06772913,0.026622038,-0.050271597,-0.047697872,-0.049789358,-0.013129921,-0.08501408,0.009007627,0.081429005,0.06278037,-0.013523542,-0.07750764,0.010200182,0.0653458,0.025872126,0.060078815,0.0067990148,-0.015316349,0.023442406,0.077068776,0.03730362,-0.05092283,-0.017741978,0.016089428,0.06591336,-0.056140386,-0.06394211,0.025324512,0.014966248,0.00037023323,-0.03702948,0.1432007,-0.10224932 +7.6.2.12,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme that exports capsular polysaccharide in Gram-negative bacteria.",384,1.0,-0.04431283,-0.08765354,-0.014880958,-0.035722785,-0.09042638,0.008820725,0.051229138,0.0499675,0.059495766,-0.016869936,0.049659923,-0.045197494,0.012389708,0.10332878,-0.06373489,-0.084626965,-0.033132013,0.036713384,0.03692134,-0.0052985894,0.04681235,0.083663315,-0.05160693,0.005927552,-0.036870934,0.007897071,0.005723829,-0.074343786,-0.03023876,-0.042936083,-0.09784598,-0.015140059,0.009014585,0.013508065,0.01490113,0.141115,-0.008601873,0.014402069,0.12959905,-0.012898751,0.10274985,0.0070857042,0.08179639,0.05510019,-0.1188996,-0.020240074,0.028520009,0.012546917,0.010214781,-0.028353127,-0.015307146,-0.00690874,-0.06867742,0.03781496,-0.012709851,0.08773692,-0.0039250064,-0.029249217,-0.014865963,-0.011209237,-0.04187679,-0.01495265,0.07736048,0.070890225,0.013134427,-0.040211223,-0.00066988333,0.044953447,-0.030267943,0.016202923,-0.115190186,-0.021330515,-0.060630117,0.02710723,0.039223365,-0.007349061,-0.03632297,0.0036695874,-0.026903514,-0.0055123963,-0.0034050192,-0.055762626,-0.020490909,0.037031747,-0.014104033,-0.034034606,0.0009906677,-0.0042981915,0.0017598766,0.018817743,-0.061007947,-0.0098397145,0.05201194,-0.043093085,-0.12524942,-0.034395494,0.014756935,0.061815575,0.042929493,-0.03834898,0.050661363,0.045377918,0.054548033,-0.056851648,0.005172681,-0.005919972,-0.0171182,-0.012904748,-0.0060739834,0.019738534,-0.020531407,0.08138065,-0.010605669,-0.09504328,-0.031131161,0.07501599,-0.02116512,-0.025611999,-0.06026106,-0.0098848585,-0.08719612,-0.13395524,0.042431407,-0.04671393,-0.04083823,0.0223163,-0.02614669,-1.1626019e-33,-0.108250916,-0.09153738,0.060105313,-0.022975408,0.005318042,-0.046223484,-0.028896341,-0.05790923,-0.016070701,-0.09545697,-0.005215281,-0.041451413,0.005120482,0.10800918,0.00037806592,0.008603995,-0.0677434,0.01878506,0.05613398,-0.039116833,0.033449374,0.036304507,0.03694518,-0.056029648,0.08371744,-0.0011891503,-0.053278025,-0.010546181,0.07495361,-0.007239515,0.007261881,-0.01982104,-0.10070608,-0.0013292123,0.04126443,-0.038622536,-0.06300895,-0.019884693,0.03117633,-0.043733384,-0.07424168,-0.008753885,-0.056314252,0.042919103,0.04412251,-0.018696234,-0.0038732798,0.031212283,-0.036352172,0.06850572,0.056310587,-0.11846806,0.04199885,-0.036849048,0.00014845449,-0.020017669,-0.0062792217,0.048749648,-0.050882343,0.07347744,0.08999994,0.10700488,-0.03450105,-0.011385467,0.040655613,0.058473434,-0.089264035,-0.0894616,0.030711742,0.066144906,-0.0027440824,0.006076949,-0.0054331427,0.0793745,0.066568315,0.03148873,-0.06985579,-0.017239366,0.015608064,0.0016903597,-0.014466431,-0.054019,0.042783123,-0.0028252576,-0.08250839,-0.038623262,0.0033974869,-0.031331863,0.015940238,-0.00014300608,0.1088176,0.03159148,-0.0858361,0.12966612,0.027541416,-1.2280973e-33,0.10562874,-0.04244211,0.07058747,-0.04468104,-0.056025248,0.0077779302,0.038138308,-0.025922567,0.015720515,-0.044165466,0.01068723,0.06026426,-0.03411713,0.030300967,0.023881387,-0.077068284,0.015132652,0.04583629,-0.055792015,-0.010157993,-0.0010859896,0.024796957,0.017546754,0.03610934,-0.04445713,-0.01814788,-0.055213884,0.10241175,-0.039263956,0.009916935,-0.002317068,0.07828923,0.02909728,-0.044730224,-0.07100521,-0.01994406,-0.0531335,0.036450505,0.021729598,-0.004601317,0.0272206,0.06780777,0.048000086,0.026850987,-0.008601413,0.04458421,-0.017585328,0.028002549,0.046228684,-0.009216392,-0.016571755,0.016536491,0.009402382,0.0071090134,0.073573895,0.119765535,-0.026044913,-0.015061508,0.06810492,-0.12550779,-0.07547987,-0.061877184,0.07700361,-0.072158605,0.008648801,-0.01751719,0.04300772,-0.060647644,-0.031980377,0.04792588,0.091265276,0.05351677,-0.041898817,0.015523499,0.010752747,0.019278236,-0.053478416,-0.027301671,-0.06780063,-0.018699592,-0.03561438,0.055160765,-0.03867561,-0.031292003,0.11926761,-0.008713798,0.013608099,-0.014983666,0.008676698,0.043669987,0.050568867,-0.008506102,0.002691807,0.064530596,0.0015463345,-3.052624e-08,0.016818857,-0.027004993,0.0078004063,-0.0602623,-0.04028951,0.07112623,-0.031334788,-0.028065328,0.07151499,0.030664496,0.024327125,0.106812716,-0.0032173141,0.054575775,0.05413681,0.07546831,-0.044737697,-0.007166611,-0.01412514,-0.06475772,-0.060227703,-0.046934817,-0.054826893,0.110559724,0.046417497,-0.029384596,0.043522395,0.053803664,-0.0008246318,-0.09290582,0.05976958,0.060226936,-0.037192695,-0.02642613,-0.02317019,0.046499547,-0.02072482,0.008056453,-0.033215318,0.09219861,0.03774446,-0.032109346,-0.07188056,0.009037428,0.04773269,0.09048366,-0.08036856,0.08777673,-0.063372575,0.016717557,0.040795043,-0.000108818094,-0.033753004,-0.0046694633,-0.057230838,-0.0063365605,-0.07971482,-0.02129988,-0.030795366,0.01264861,0.022548867,0.024439162,0.108789064,-0.011455065 +1.13.11.88,"Contains iron(II). The enzyme, charcterised from the bacteria Pseudomonas putida and Pseudomonas nitroreducens, catalyses the epoxidation of the double bond in the side chain of isoeugenol, followed by a second oxygenation and cleavage of the side chain in the form of acetaldehyde.",384,1.0,-0.02243477,-0.017760376,-0.075638495,0.113031685,0.1093523,0.052582517,-0.052473858,-0.023744099,-0.012260767,-0.05439457,0.04000316,-0.043122273,-0.057927955,-0.01639876,-0.052858435,-0.035824984,-0.066907376,0.044871543,-0.0065161698,0.026359195,0.017658493,0.010194413,-0.008471164,-0.030218046,-0.0107748965,0.08469912,0.08015125,-0.007729434,0.006562132,-0.043420423,-0.0014516144,-0.100602925,0.079759754,-0.12264615,0.05213002,0.022750517,0.04025662,-0.021288851,0.04853813,-0.045665342,-0.050436858,-0.030746,-0.025865758,-0.037979357,-0.0042663123,-0.047891058,0.087412655,0.013785943,0.014251624,0.004639966,-0.027096756,-0.025595432,-0.032709427,0.051675957,0.044877045,0.0017209131,0.010311823,-0.055994317,-0.026460676,0.027732363,0.065128356,-0.046940263,-0.05858932,0.013590954,-0.03184092,-0.012758545,0.108446054,-0.023526235,-0.04002722,-0.06575135,-0.004236127,-0.007551911,-0.029689942,0.02242718,-0.003920232,0.04957193,0.029564705,-0.09210401,0.08358336,0.019864652,-0.030496562,-0.012662694,0.020541852,0.12329878,0.027081583,0.01105955,-0.004906508,-0.010634043,0.0024584488,0.035837658,-0.008516154,0.0067867315,-0.03378154,-0.072117805,-0.003800859,0.07982395,0.011895974,0.09013855,0.084711924,-0.007973196,-0.042076703,0.040563468,-0.03586097,-0.121510185,-0.027578546,0.048994843,-0.008011131,0.100713186,0.0906134,0.04031763,0.017936962,-0.005470426,0.026465382,-0.012224151,0.007696559,0.014025006,0.11652044,-0.066454455,-0.07550814,0.015530694,0.0534902,0.00505637,0.043912176,0.052774698,-0.04231939,-0.059132032,-0.0529783,3.338259e-33,0.019638447,0.043480236,-0.013344757,-0.009207052,0.010216307,0.023291092,-0.11074467,0.012605326,-0.016495423,0.014947301,-0.08982954,-0.06544415,0.032819264,-0.013967528,-0.018480876,-0.015139739,-0.04507911,-0.013814732,0.09684188,0.004745127,0.012387837,0.05984724,-0.0022518535,0.0029551762,0.041534074,0.028878521,0.015340311,-0.044840783,-0.022070723,-0.0100425035,0.061673988,-0.07122433,-0.10262005,-0.03292682,0.07466567,0.0061559663,0.00021946931,0.024697388,-0.07340748,0.045484908,0.083027,0.056428175,-0.05664183,-0.03997507,0.05140146,-0.12045415,-0.07966361,0.14618292,0.042042032,0.09552986,0.026523275,0.0022856668,0.026928088,0.023363277,-0.11170149,0.04512496,-0.008457287,0.024875816,0.04811129,0.042835698,0.017337034,0.072934985,0.042337477,0.026674397,0.012574992,0.009991529,-0.035662662,0.045556378,0.04816102,0.008213867,-0.0908096,0.036272753,0.04721162,0.023193702,-0.021040788,-0.091543175,-0.12921678,0.009330584,0.09856009,0.01122004,-0.05774247,-0.038701165,-0.0034600596,-0.06139741,-0.070492685,0.018580679,-0.08137064,0.017744403,-0.0025420291,-0.050924063,0.06571514,-0.105895594,-0.05578373,-0.02349606,-0.014584104,-5.2592187e-33,0.046908263,-0.12370534,0.07752124,-0.08628567,-0.046031438,0.023141237,-0.052990057,-0.014884875,-0.026156608,0.002416135,0.10659615,-0.022773586,0.018874722,-0.0121385055,0.03708817,0.039064195,0.031227207,0.08288028,0.07129047,-0.04957055,0.0022828847,0.007324745,-0.023821007,0.05047339,0.06805509,0.05176405,-0.025961056,-0.0022433088,0.1279981,0.110207915,0.049309272,-0.008896919,-0.02585307,-0.064026095,0.0026119812,0.02564577,-0.007863272,0.009107417,0.042169675,-0.017434496,0.050547343,-0.02430634,-0.01954765,0.108893625,0.006112146,0.06709877,-0.1196704,0.026926752,0.014038897,-0.055335674,0.067705795,0.009214134,-0.09388049,0.026155977,0.041745503,-0.0051761875,0.003167664,0.026542066,-0.013461682,-0.013200709,-0.05949448,-0.043951835,0.028734572,0.026137495,0.043237355,0.019830594,-0.02758225,0.060833033,-0.0179725,-0.056452557,-0.0027843495,0.022669828,0.0020789988,-0.0114563955,-0.015644599,0.010350565,0.0160408,-0.02839398,0.009863364,0.03800598,0.00539231,-0.052566763,-0.06620806,-0.028582657,-0.04362978,-0.06929138,-0.014816682,0.057193384,-0.02567165,-0.047787674,-0.047276527,0.017894132,-0.024722451,-0.0009893463,0.033723865,-4.2092015e-08,0.0031309123,-0.072009,0.052964244,-0.033525623,-0.034117375,0.032599546,0.012174209,-0.0019751107,-0.016788965,-0.04240733,0.011148792,0.10869397,-0.033407252,-0.042689677,0.024412835,-0.021456402,-0.045778453,0.031888694,-0.022037044,0.005125064,-0.09317796,-0.010340622,-0.04703665,-0.02024556,-0.015648985,-0.08082671,0.022917574,-0.06511971,0.01666047,-0.021438133,-0.033346232,0.024690792,-0.0463345,-0.035754204,-0.07955053,-0.004029715,0.042778082,-0.034732644,-0.068201475,-0.009404173,-0.012652067,-0.056501526,-0.11602002,-0.043457955,0.043226354,0.011450217,-0.0028779514,0.066569954,-0.04550589,-0.053529207,0.03181053,-0.042617213,0.048410077,-0.02122335,-0.12633252,0.10299854,0.021557027,-0.019047463,0.033533134,0.039050553,-0.019780342,0.028220298,0.17099105,0.00789665 +1.14.11.61,"Requires iron(II) and ascorbate. The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process. The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA. cf. EC 1.14.11.62, trans-4-coumaroyl-CoA 2-hydroxylase.",384,0.99999994,-0.034587476,-0.04449373,-0.14484055,0.094936766,0.06367287,0.108326,-0.04256819,0.012003758,-0.007098646,-0.041553576,0.047179487,-0.04757723,-0.12358822,0.018501263,-0.043166805,-0.03770126,-0.05921708,0.016487274,-0.031858712,-0.045062978,0.084933445,0.013222025,-0.026379762,0.029260082,0.03324741,-0.029846199,-0.00039596256,-0.08279457,0.022935966,-0.052912682,-0.033290703,-0.037965484,-0.007745563,-0.029562263,-0.017633406,0.035995625,0.036041796,-0.10304176,0.0675779,0.031983647,0.10216408,-0.07562869,-0.021314597,-0.056935366,-0.066451885,-0.053037334,0.016215278,-0.0068576992,0.03264999,-0.010266232,-0.090587825,-0.040937845,-0.055992093,0.029127847,-0.019169394,-0.0029899464,0.01978104,-0.0035037047,0.03347884,0.06688767,0.06608998,-0.046900097,-0.039240085,-0.014388443,-0.030801965,-0.071598426,-0.01906327,-0.021042617,0.030600008,0.006824287,-0.032306552,-0.02978394,-0.08899176,0.022546915,-0.06576474,0.079346076,-0.04173871,-0.015605161,0.009494819,-0.031861704,0.020650957,0.029536199,0.0162921,0.07714585,0.009093994,0.051348496,-0.031346075,0.02140838,0.0034125445,0.046165895,0.03486789,0.06448193,0.00079365325,0.013313433,-0.062885106,0.09543107,0.07312226,-0.04650996,0.02363239,-0.016763851,-0.06993943,0.017579684,-0.03888798,-0.067265764,-0.09567426,-0.013137272,-0.11215895,0.05575548,0.034275115,0.030373529,0.012948888,-0.028300865,0.022087412,-0.002925867,-0.001106293,0.103361316,-0.012488768,-0.064076535,-0.03558811,0.029176084,0.022895988,0.024918186,0.058031883,0.07771366,0.038031805,0.02820742,-0.02817223,1.9303955e-33,0.054821588,0.0408766,0.0060567297,0.085866846,-0.05993365,-0.040379245,-0.100166954,-0.013311622,-0.046458296,-0.06382624,0.0013254797,-0.02422799,0.034914643,0.016682709,-0.030706434,-0.04413822,0.0412222,-0.0069937054,0.10538794,0.027011823,0.036077593,0.061333917,-0.031793818,-0.001999492,-0.044238456,0.024686009,0.010292633,0.005019385,0.049980555,-0.00014661776,0.0574233,-0.040361438,-0.058025293,-0.011632426,0.104308695,-0.0032246325,-0.014957593,-0.03271118,-0.06344806,0.07406974,0.059802093,-0.014516191,-0.04644651,-0.04325517,0.13315728,-0.044110633,-0.061211213,0.06791855,0.05243926,0.07957915,-0.012586851,0.07379864,0.08852599,0.05416278,-0.038169675,0.007469315,-0.012677541,-0.017937953,0.07691519,0.018745989,0.014879868,0.028790705,-0.05272679,0.060849193,0.0877,0.05588214,-0.06361679,-0.06347545,-0.01974446,0.021287953,-0.02505243,-0.07600532,0.04564735,0.0239063,0.02879409,-0.013367911,-0.0685661,0.07198943,-0.010546115,0.04158037,-0.053297147,0.034360286,-0.008025614,-0.011239155,-0.024828667,-0.030065374,-0.040997364,0.029880477,0.010891222,-0.02905505,0.10493836,-0.011180945,-0.03437922,-0.002284755,0.029238971,-1.7215025e-33,0.117573254,-0.09407318,-0.04501466,-0.032976158,-0.094495654,0.040008117,0.002201381,-0.09788605,-0.036312267,0.026386626,0.14836709,0.03048638,-0.014109238,-0.02134969,-0.008890461,-0.035698626,0.05711908,0.070453845,0.008978571,-0.013277807,0.023443274,0.10488362,0.015644338,0.08095875,0.096207574,-0.014559601,0.042834047,0.05578778,-0.03065604,0.027241794,0.063492894,-0.06800088,-0.06855837,-0.07558564,-0.039043903,-0.03768421,-0.05781164,0.114057735,0.021078829,-0.007936386,-0.013303388,-0.022754554,0.045345683,0.0412403,0.071082905,-0.050070323,-0.12762733,0.04317975,-0.01596167,0.028037664,0.0012211204,0.006783247,-0.0627999,-0.07167772,0.012965819,-0.020761205,0.00655915,0.036799606,0.02783073,-0.004879311,-0.014117591,-0.0035272462,0.041852888,-0.031036668,0.082885966,0.08652185,-0.022015367,0.013188833,0.021977397,0.00029990918,0.043800488,-0.003920305,0.066576466,0.045933552,-0.008940768,-0.030304402,-0.007853994,-0.013328318,-0.07336208,-0.011966458,-0.057422776,-0.0738149,0.011497908,-0.06779769,-0.023315137,-0.08121978,-0.026782988,0.023628293,0.04387019,0.0035282809,-0.03755897,-0.10427242,0.003922937,0.004183193,0.10078026,-4.192765e-08,-0.05287569,-0.025932258,0.04086598,-0.046411347,0.005356187,-0.011512193,-0.0007609617,-0.07612829,0.07886868,-0.040864576,-0.075097196,0.03442668,0.095965974,0.0771913,0.06245087,-0.008517929,0.06792606,0.072336026,-0.016897598,-0.03720759,-0.08760794,-0.065090366,-0.060802985,0.02460271,-0.014060097,-0.09479158,0.054084115,0.048270486,0.08933824,-0.0010788126,0.06123208,0.028879711,0.104554646,0.024364294,-0.05909731,-0.0041377484,0.057496984,0.0013483161,-0.06499358,0.025855407,-0.028579898,-0.014186554,-0.033166017,-0.019736104,-0.02259619,0.009393568,0.016581299,0.03921479,0.02979689,0.04434092,0.03974454,-0.008529357,-0.016022705,-0.03165967,-0.038057294,-0.0015475778,0.053020004,-0.035870757,-0.00017034628,0.009864144,0.013472775,0.0058375397,0.1367634,-0.014171452 +1.14.11.62,"Requires iron(II) and ascorbate. The product spontaneously undergoes trans-cis isomerization followed by lactonization and cyclization, liberating CoA and forming umbelliferone. The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-feruloyl-CoA (cf. EC 1.14.11.61, feruloyl-CoA 6-hydroxylase).",384,1.0,-0.038262077,-0.039385762,-0.13546473,0.10856278,0.024296714,0.04149853,-0.015824376,-0.019660952,-0.014138925,-0.06977673,0.08085395,-0.03356107,-0.1175231,0.02838401,-0.010595975,-0.033431873,-0.050372466,0.061212018,-0.07412512,0.035663567,0.10078127,0.009628318,-0.022383327,0.02589904,0.043996558,-0.06630163,0.0036731255,-0.06555811,0.0087462105,-0.11091986,-0.040693015,-0.079637416,0.057941217,-0.04185482,0.00036152662,0.03255928,0.014804079,-0.088950366,0.041920822,0.009312553,0.067528315,-0.0872224,-0.0070810565,-0.024847358,-0.06943269,-0.043700233,0.059011426,0.0034020238,0.022001388,-0.021244362,-0.07033467,-0.03840218,-0.046449047,0.057457946,-0.06861679,0.008017204,0.033830047,0.0014239872,-0.010827392,0.034901056,0.019114334,-0.019347716,-0.046487026,-0.016540006,-0.044190913,-0.05438385,-0.02415479,-0.018800696,0.03192808,-0.028868826,0.016542567,-0.07283772,-0.080357276,0.018849177,-0.03152265,0.079026006,-0.01977469,0.010722457,0.021202682,-0.018731112,0.0050635664,0.01947759,0.004077503,0.05251604,0.021290356,0.055441786,-0.02281418,0.017967004,-0.047407895,0.04033915,0.050966438,0.07038135,-0.019490616,-0.008065456,-0.053898193,0.058735747,0.076211035,0.011555605,0.06081091,-0.013420468,-0.041766137,0.025732728,-0.05797987,-0.059408557,-0.08672402,0.0017972201,-0.14873359,0.018609732,0.0047621913,-0.0044337665,0.019290773,-0.010491544,-0.0028101741,0.010161826,-0.000110438465,0.04398245,0.029794723,-0.03480368,-0.058459938,0.045587882,-0.0109099,0.029849092,0.017464366,0.0878556,-0.017508712,0.04132786,-0.063597456,3.9274453e-33,0.019882655,0.030723287,-0.057811692,0.035334375,-0.026155643,-0.015008394,-0.09487853,-0.026655013,-0.044492822,-0.040618196,-0.038851734,-0.028234622,0.033626676,-0.014036293,-0.01996353,-0.06695044,0.051024124,-0.010423714,0.12393154,0.009773553,0.060391396,0.067990124,-0.011441064,-0.03437573,-0.07002802,0.048016537,0.00060815533,-0.005009832,0.022217797,-0.0014742109,0.06637541,-0.10485508,-0.061263073,-0.020167667,0.08985962,-0.007901207,-0.0057340865,-0.042540204,-0.04885161,0.02784165,0.027209667,0.019197486,-0.086901896,-0.034578755,0.13335948,-0.039983753,-0.034892235,0.14180613,0.078394346,0.07258908,-0.021482507,0.039178964,0.079018064,0.008574672,-0.031636078,0.0144130755,-0.028807985,-0.010557465,0.054586284,0.03335415,0.029755436,0.05427721,-0.04599284,0.035107467,0.05458008,0.081295915,-0.068412825,0.013213332,-0.01046379,0.04497116,-0.06168599,-0.08259333,0.008203653,0.033442594,0.002728181,0.0075355535,-0.086274296,0.026241694,0.044563595,0.02412141,-0.028007172,0.07505422,-0.011823698,-0.00024100205,-0.043412153,-0.010499851,-0.03157786,0.037482698,-0.015846,0.050143495,0.14071105,-0.007824374,-0.017966442,0.0025986235,0.07876325,-3.4441727e-33,0.14931065,-0.12646006,-0.030298559,-0.061433624,-0.059828497,0.0028989743,-0.016047196,-0.071147464,-0.03291153,0.030227382,0.07284006,0.027329296,-0.02564659,-0.049879126,-0.022856792,-0.03322801,0.0813614,0.13157499,0.024527015,-0.013977063,-0.037001766,0.1134375,-0.02397609,0.05283296,0.03727273,-0.030088494,-0.010575733,0.07959465,0.036435902,0.024434967,0.054255713,-0.03240488,-0.045812413,-0.10670328,-0.045382865,0.004140177,-0.041845456,0.06449767,0.069069915,0.022131102,-0.013604281,-0.009953112,-0.0037336394,0.03547648,0.08287298,-0.012471238,-0.13406503,0.026305871,-0.031766135,0.01589761,0.027573707,-0.023983892,-0.02259822,-0.048374224,0.012484416,-0.042237088,0.029612672,0.03729506,0.012789607,-0.008542882,-0.005063779,-0.059875492,0.041575298,-0.04707595,0.04152979,0.07817938,0.010498048,0.011464871,0.0019529372,0.061893474,0.07197276,0.054786947,0.018742733,0.006817261,-0.009134396,-0.0073765055,0.013520219,0.0045069763,-0.05542325,-0.004779711,-0.030109078,-0.04421278,-0.022384405,-0.026107324,0.021431599,-0.07131762,-0.01050371,0.04755357,0.023446683,0.0076446324,-0.013006183,-0.109920524,0.007055565,0.034680665,0.13038714,-4.385132e-08,-0.046381813,-0.041014828,0.046214923,-0.051703297,0.023541508,0.0050689834,-0.0052534626,-0.06117926,0.042029556,-0.05184866,-0.03354191,0.07194921,0.098843366,0.02545405,0.06818583,-0.018581323,0.09823507,0.089191586,0.0032845743,0.007848048,-0.08763554,-0.021844123,-0.08460524,0.02212035,-0.0132994605,-0.092702635,0.08181761,0.023973232,0.06671108,0.008938694,0.08064459,0.015780095,0.05533546,0.003462609,-0.03967866,-0.004863297,0.04425153,-0.02042866,-0.048829302,-0.028240796,-0.013904953,-0.025376948,-0.04806332,0.016822455,0.021598384,0.007831032,-0.024392165,0.01144402,-0.027527172,0.022447992,0.08600644,-0.023380034,0.0071370634,-0.0415626,-0.0667578,0.027485901,0.053310726,-0.031597916,-0.011531605,0.0341731,0.031526268,0.011811618,0.15503545,-0.0849935 +1.14.11.63,"Requires iron(II). The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.",384,1.0,-0.061263863,-0.088046044,-0.04797006,0.054073118,0.094783135,-0.0052539324,0.0111923395,0.025449093,-0.025348023,-0.033666834,-0.050984386,-0.03516986,-0.08957661,0.057010356,0.04961134,-0.011199292,-0.049722843,0.065398,-0.040627997,-0.05474268,0.06596799,0.041365303,0.0431653,-0.07897925,-0.0025100394,-0.0091304025,0.1340829,0.03909043,0.041868154,-0.02886825,-0.042386312,-0.058042787,0.0030478474,0.02992048,-0.021085903,0.05947601,-0.05391656,-0.07939918,-0.042248864,-0.05224966,0.030415384,0.007861763,0.026058644,-0.05317894,-0.009367289,-0.027959295,0.008578367,0.012481802,-0.030520467,0.111793794,-0.041742273,-0.015345901,-0.015886273,0.01933444,-0.04342077,0.0014878825,-0.043741472,-0.022374997,-0.0050949,0.0047465945,-0.017484827,-0.044690426,-0.012736143,-0.039717954,0.07782683,-0.0744511,0.043290004,-0.042452056,-0.04906264,-0.07513033,-0.009168411,-0.042811297,-0.07003095,0.016667461,0.0010675645,0.09794432,0.0021388978,-0.0046776175,0.049489584,-0.0675365,0.061880704,0.02455558,0.14800479,0.10887136,-0.0029184578,0.065710746,-0.012447817,0.044928797,-0.021203745,0.0806798,0.043563716,-0.030949743,-0.0077331467,0.03166444,-0.02137147,0.014991063,0.026526198,0.04012744,-0.025912354,0.015314267,-0.032138493,0.10130014,0.021068567,0.034090493,-0.016704261,-0.01940138,-0.07923897,0.10555556,-0.025437295,-0.085454285,0.06819157,0.0374813,0.080815144,0.065221414,0.016261367,0.011599901,0.056400143,-0.04769668,-0.03744587,0.016027665,0.030862141,0.032161385,0.024668278,0.078071885,-0.058485422,0.041524794,-0.13241263,6.945186e-34,0.010001003,0.005414011,0.043207224,-0.009848854,-0.07043106,0.0041012154,-0.106324986,-0.030475192,-0.011896407,-0.0002176826,-0.105319105,-0.051439945,0.054606326,0.011574179,-0.08344989,-0.016599812,-0.012412353,-0.042604778,0.02532878,0.038399585,0.040857397,0.09219219,-0.012463575,-0.019385329,-0.022781508,0.13378227,-0.044775378,0.05533656,0.028676817,0.0021703998,-0.07736283,-0.11827349,-0.04985368,0.03831849,0.044443574,0.020871338,-0.013291521,-0.09067437,-0.023811575,-0.0068266117,0.05576708,-0.0054131756,-0.05748619,-0.037196796,0.07828016,-0.054602046,-0.0045011896,0.04042761,-0.095006734,0.10972626,0.01635777,0.046529256,0.04747504,-0.0452457,-0.04299864,0.009131453,-0.022327272,0.0051465933,0.039099734,0.07188909,0.02147672,0.03383316,-0.022630515,0.12137604,0.056994162,0.010231531,-0.0867722,-0.040527966,-0.07423246,0.10270312,0.015370356,-2.2027325e-05,0.090300724,0.012852267,0.029742865,-0.12264617,-0.014963655,0.033472944,0.024724923,-0.0060107387,-0.057731487,0.02222656,-0.07503364,-0.05244151,-0.07661461,-0.010640122,0.0014595282,-0.090878256,-0.034089416,-0.0009763455,0.034768444,0.000906192,-0.072771996,0.035139363,0.0408986,-3.1840615e-33,-0.022809384,-0.018818617,0.056384563,-0.0020559991,-0.061325092,0.005441295,0.039793555,-0.07058135,0.0018771043,-0.0145439105,0.06816219,-0.037968036,-0.013891952,-0.025708405,0.02535372,0.026351644,-0.033800155,0.050862264,0.01783428,0.024464164,-0.011944936,0.119985275,0.059285965,0.117241755,0.061765388,-0.028683014,-0.0064537325,0.045585956,-0.005388745,0.105858386,-0.003694772,0.05727268,-0.054406676,-0.123282164,-0.014996412,-0.056299727,-0.00080589496,0.030451896,0.015689576,0.014506872,-0.03588665,0.022771843,0.03246452,0.118363656,0.0034775056,0.099055514,-0.021931166,0.028952777,-0.009604302,-0.0375699,-0.03092095,-0.009856334,-0.02445938,0.013707569,0.010436688,0.03322973,0.059208043,0.024277378,-0.026090194,0.07210019,-0.0029052496,-0.063037515,-0.0032570832,-0.008359182,0.06287084,-0.025796002,0.025537318,0.07092319,0.055332705,-0.012447926,0.08044136,-0.023373393,0.067006074,0.0019904624,0.0019946885,-0.041838463,-0.040370736,0.02604936,-0.0028151916,-0.054429524,-0.002537384,0.018253922,-0.013669062,-0.0066497605,0.011328255,-0.10307993,0.027565513,0.06132416,-0.016532753,-0.008181364,-0.036330048,-0.048364773,-0.054630317,0.02893726,0.0012716376,-3.669351e-08,-0.00074078975,-0.1006707,0.0100161545,-0.13882156,-0.01682457,0.0065331263,-0.098740175,-0.017047208,-0.0023206954,0.031349942,0.0040388256,0.08937162,-0.029817803,0.032321837,0.044011388,0.038199246,-0.027923098,0.079108,-0.03322091,0.018587524,-0.041763727,-0.06410402,-0.009815817,0.048451222,0.04038612,-0.08411269,-0.014948993,0.017708626,0.06673351,-0.041346185,-0.006943978,0.019087862,0.014345553,-0.018806987,-0.12732671,-0.023821933,0.027722863,-0.045488637,0.0020784417,-0.00019056867,-0.01265603,-0.03404801,-0.056679603,6.909506e-05,-0.047744874,0.018216915,0.010064207,-0.010160696,-0.02151885,0.00039552667,-0.015275736,-0.050057903,0.03936723,-0.035629917,-0.038832534,0.039682236,0.014474265,-0.021438587,0.072357886,-0.06381148,0.0057212715,0.09833444,0.05977931,-0.12741649 +1.14.13.243,"The enzyme, characterized from the bacterium Burkholderia cepacia, belongs to a class of nonheme, oxygen-dependent diiron enzymes. It contains a hydroxylase component with two binuclear iron centers, an NADH-oxidoreductase component containing FAD and a [2Fe-2S] iron-sulfur cluster, and a third component involved in electron transfer between the hydroxylase and the reductase. The enzyme dihydroxylates its substrate in two sequential hydroxylations, initially forming 2-methylphenol, which is hydroxylated to 3-methylcatechol.",384,0.99999994,-0.003983731,-0.05621303,-0.11516452,-0.0036286665,0.09144953,0.026036182,-0.08765393,0.015947469,0.04110107,-0.09335265,0.03863492,-0.10376174,-0.042046502,0.010704665,-0.07274897,0.06868581,-0.08671965,-0.00860087,-0.030930936,0.023792258,0.07257354,0.05476479,0.026585653,0.062611036,-0.017169,0.0767212,0.106937416,0.029318433,-0.049881265,-0.07370883,-0.0048190313,-0.006922962,0.06326979,-0.0127854915,0.048770886,0.10572686,0.008610172,-0.046902448,0.030039575,0.020228855,0.020657534,-0.007918014,-0.023553878,-0.0066074324,-0.06093212,-0.06264162,0.009658182,0.083456166,0.061749097,-0.030135773,-0.091861226,-0.07099117,-0.024831085,0.07050601,0.009546915,0.029617157,0.061950367,-0.023261208,-0.049016718,-0.0058346093,0.060099162,-0.019804375,-0.023212545,0.00908011,-0.007527747,-0.03029143,-0.012948453,-0.100341484,-0.018744256,-0.10272447,-0.094801374,-0.049068548,0.038567226,0.025554746,-0.022899965,0.024094993,0.004183342,-0.028892295,0.08470803,-0.06620389,0.023157518,0.007695474,0.01677701,0.10419546,0.051356845,-0.029926317,-0.031650476,-0.0041988716,-0.0021615657,-0.00069048034,0.017436044,0.032363445,-0.0390438,-0.02636262,-0.06836062,0.046884093,0.051768977,0.06074297,0.04737102,-0.009555637,-0.03704123,0.045042563,-0.002971096,-0.10513216,-0.08697891,-0.042450145,0.02868267,0.13944484,0.02760128,-0.005878188,0.03534988,-0.028594868,-0.0005027738,0.01647817,-0.02061985,0.12838241,0.06188946,-0.07363677,-0.08730387,-0.028035453,0.027100908,-0.046045702,0.045919385,-0.0120487185,-0.03632125,-0.04543448,-0.12432944,3.297824e-33,0.10150093,0.014425188,-0.04964546,0.010228058,0.026927521,0.020971352,-0.10896715,0.053290285,0.008811666,-0.048073336,-0.028554814,-0.004751004,-0.0004958045,-0.008251649,-0.013586397,-0.0825286,-0.03880287,0.03366942,0.05359319,0.046400603,0.06964374,0.05692108,-0.05400013,-0.049416363,0.008149341,0.06506522,-0.035512213,0.012996831,0.02826645,0.010994489,0.077637464,-0.113112606,-0.104727775,-0.05249086,0.05971207,-5.3442604e-06,-0.023898335,-0.004539175,-0.058263298,0.021917185,0.013272615,0.024619078,0.028532924,-0.04159153,0.029705146,-0.111509964,-0.059099693,0.092657275,0.06369477,0.065267675,0.023568753,-0.034161475,0.104299314,-0.025173036,-0.050128978,-0.020409955,-0.014708716,-0.014557727,0.0024174962,0.04230001,0.032037158,0.08607518,-0.040836412,0.059983116,0.0057203714,-0.056032892,-0.028668605,0.016067417,0.052806824,0.10768706,-0.024214104,0.035825748,0.028780274,0.025018463,-0.024341792,-0.08817767,-0.030337788,0.0374584,0.006213342,0.014049564,-0.007146299,-0.045089733,0.021368874,-0.018593848,-0.07406234,0.09125835,-0.026783852,0.014547494,-0.021536827,-0.019824708,0.016975762,-0.069626465,0.00030931775,-0.0488588,0.029413944,-4.0567104e-33,0.07215557,-0.09265709,0.06318949,-0.0873471,-0.026410686,0.07918008,-0.016815167,0.037041254,-0.009162403,-0.0040538805,0.090935655,0.04456769,0.047535792,-0.068567626,0.058267843,0.059239514,-0.04035448,0.037091695,-0.020939765,-0.026447183,0.046579495,0.087089,0.02187657,-0.0046133674,0.028926473,0.005390474,-0.016259385,0.05524101,0.048928548,0.07638145,-0.010160645,0.037139736,-0.026755638,-0.027029976,-0.04370854,0.025350953,-0.15089971,-0.0055734995,0.016773146,0.045091297,0.0074560535,-0.017656744,-0.036641072,0.07999026,0.034068573,0.07350964,-0.07665719,-0.01181301,0.06207172,0.004291931,0.012597185,-0.017737392,-0.052436426,0.025574831,0.029305385,0.03802494,-0.022903215,0.048793115,-0.031308204,-0.024705501,-0.047941193,-0.06580615,0.0061884173,-0.025371738,0.024982776,0.026673134,-0.0730043,0.05881417,0.0449921,-0.0082592955,0.04037527,-0.02324875,0.003904669,0.07891478,-0.077955745,-0.010085151,-0.053422537,0.0018343894,-0.022403836,0.07750961,0.04107392,0.019442027,0.0020382104,-0.0590231,0.010882704,-0.07804376,0.009884639,0.044772137,-0.05889201,0.040543538,-0.007766082,0.021036359,-0.022443065,0.009915447,0.030580899,-4.435935e-08,-0.004117725,-0.08513501,0.08925312,-0.01961983,0.010602224,0.018815875,-0.02245099,-0.03245487,0.035972547,0.008443021,-0.012790707,0.08090722,-0.0021434384,-0.0019184286,-0.0021434266,0.052037966,-0.0029422948,0.0182866,-0.011700905,0.0071999966,-0.043190796,-0.0409565,-0.055793136,0.056992363,0.018410558,-0.0530573,-0.023378711,-0.01320331,0.031756092,-0.028592888,0.007202015,0.048868235,0.017548865,-0.0223453,-0.10013562,0.011665158,-0.119016856,0.0029435046,-0.118151166,0.050307225,0.054831523,-0.06570546,-0.07984888,0.01367576,0.0123402625,0.0064319144,-0.025954124,0.022089224,0.012001697,0.007748952,0.024482775,-0.021504732,0.060380876,-0.03989931,-0.13565476,0.05404146,-0.0071236966,-0.037707787,-0.007913658,-0.02763767,0.040325508,0.049569968,0.17192246,-0.018892797 +1.14.13.244,"The enzyme, characterized from the bacteria Pseudomonas sp. CF600 and Acinetobacter radioresistens, consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The reductase component is responsible for transferring electrons from NADH to the dinuclear iron center.",384,1.0,-0.040657,-0.065019496,-0.18033111,0.054893028,0.09262782,0.061303023,-0.024539586,0.044328384,-0.008391226,-0.06053486,0.0152022205,-0.06405206,-0.02470797,0.048568733,-0.065611504,-0.022506014,-0.10439921,-0.030539284,-0.008362867,-0.034977652,-0.023726624,0.07359071,-0.022267457,-0.062136248,0.05018919,0.03218645,0.04988236,-0.026645456,-0.058832217,-0.032978423,0.0016854993,-0.019849364,0.0922453,-0.035190467,0.084179126,0.06699903,0.0007599469,-0.01128359,0.030223684,0.017373865,0.016713073,-0.007255937,0.01726337,-0.019824114,-0.043143626,0.025938706,0.034636322,0.056763146,0.061660543,-0.012882815,-0.014329722,-0.03254048,-0.024363862,0.12673537,0.02791425,0.07282669,0.02539311,-0.095349714,-0.021815183,-0.025464695,0.027631547,-0.058282994,-0.027771395,0.0115209315,0.048042957,-0.04439983,0.055857245,-0.05749373,-0.01402607,-0.06571113,-0.085859224,-0.04166455,-0.010750976,-0.008685988,0.025065623,-0.013157116,0.0072193155,-0.0642397,0.09722337,0.013279014,-0.030523783,0.008802849,0.04333964,0.09254986,0.014694336,-0.026613362,0.046884,-0.027508525,-0.008429519,0.019905943,-0.037484486,-0.010030827,-0.022645336,-0.102750294,-0.08649801,0.03990651,0.031545825,0.08469582,0.053611442,-0.028324328,0.00025804612,0.060969945,0.002198687,-0.103496626,-0.070358664,-0.05748541,-0.010463156,0.17862976,0.03944908,0.027230116,0.020238519,0.038526997,0.0036866537,-0.08083027,0.020184224,0.06462363,0.045111835,-0.042668086,-0.08497308,0.033271234,0.00839282,-0.03578536,0.035165492,0.05459296,0.04296592,-0.092721105,-0.13011949,2.994995e-33,0.029588534,0.045167807,-0.028387956,-0.033805702,0.012810809,0.005608905,-0.103051834,0.02401413,-0.018899975,0.022725085,-0.03760355,-0.022383261,0.022125334,0.01859416,-0.035871126,-0.0571477,-0.052172016,-0.01719484,-0.020680264,0.005300537,0.06250893,0.09990076,0.012539535,0.049523372,0.06519658,0.031180365,-0.032540597,0.037365608,-0.06540182,-0.0083196955,0.05478551,-0.046492785,-0.09102103,0.003635089,0.085101165,-0.041599464,-0.05979338,-0.03203558,-0.039146148,0.03504619,0.058343597,0.057362597,-0.023968766,0.018315943,0.08668524,-0.08401129,-0.060647156,0.118648954,0.07166289,0.096343346,0.010714324,-0.025953868,0.08272954,-0.053956646,-0.03756764,0.047285616,-0.06355534,0.031340986,0.020269483,0.012768521,0.044628937,0.02190143,-0.03935032,0.06278675,-0.009044681,0.04899461,-0.022004409,-0.02525235,0.070476845,0.10169486,-0.08584366,0.058042455,0.020999074,0.062318698,-0.009569809,-0.062497612,-0.054875333,-0.030060992,0.0014137706,-0.024480058,-0.02832475,-0.06675155,-0.008549315,-0.034603637,-0.110950835,-0.03936845,-0.03124909,-0.034991376,-0.041423358,-0.058023017,0.084337056,-0.041742355,-0.0747379,-0.03825464,0.043869082,-3.681982e-33,0.07870314,-0.0846317,0.033315703,-0.09578429,-0.05979048,0.045989655,0.016075883,-0.01075922,-0.012206899,0.017507944,0.09701224,0.06383891,-0.013545026,-0.05342382,-0.020005103,0.06834823,0.046260808,0.024022065,0.03839796,0.0010876969,-0.013381939,0.034027815,0.016775602,-0.044417407,0.032125004,0.025590328,-0.07797983,0.04130908,0.08803289,0.08141017,-0.032083217,0.048932366,0.0049242894,-0.06418831,-0.061488464,-0.017410744,-0.052230436,-0.0042745085,0.013076141,-0.00066826673,0.07512368,0.0012214821,-0.06445803,0.102680355,0.019846398,0.020944249,-0.06062886,0.032070003,-0.00437206,-0.095982194,-0.0036127497,-0.04983685,0.007022227,-0.0012441832,0.02515941,0.07055216,0.018059483,-0.01175377,0.023749106,-0.032511845,0.0098251635,-0.064065546,0.057503037,0.00602376,0.045469344,0.010047501,0.03658701,0.073495135,0.008812176,0.018463211,0.046949968,0.009027615,0.028127208,-0.0077203047,-0.077079624,-0.032015797,-0.013856962,0.0685755,-0.016608708,0.06458547,-0.0064168666,0.009012415,-0.076684184,-0.04497089,0.069539994,-0.033619806,0.034533937,0.06647599,-0.03665774,-0.0016470823,-0.04391102,0.06701097,0.036974348,0.012439185,-0.032531723,-3.945845e-08,0.020951187,-0.06568208,0.034499258,-0.058854073,0.05061491,0.06152047,0.0064768866,-0.035936326,-0.024634447,0.016761245,0.0037714764,0.09779905,0.0027685417,-0.07112909,0.10628816,0.028351113,-0.082002595,0.0044099693,-0.05184293,0.00566574,-0.029541587,-0.019590504,-0.10506179,0.04951319,-0.014381054,-0.008105262,0.06714869,0.019352831,0.000609419,0.0037732767,-0.037664738,0.012846284,0.016433818,-0.023458362,-0.09149521,0.057726152,-0.023735333,-0.06280951,-0.062494,0.023119098,0.012219974,-0.004595327,-0.08269095,0.020563798,-0.0019335524,0.048194546,-0.008098105,-0.0030844244,-0.021918902,-0.023460142,0.029219188,-0.006351231,-0.0069864383,-0.021645661,-0.11664953,0.09114564,-0.006335552,-0.07722091,0.014281342,0.013965349,-0.03393481,0.0484374,0.08030567,-0.03106159 +1.14.13.245,"The enzyme, studied from the bacterium Acinetobacter sp. strain 20B, is very similar to EC 1.14.13.244, phenol 2-monooxygenase (NADH). It consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The three components comprise five different polypeptides. The enzyme catalyses the first two steps of a dimethyl sulfide oxidation pathway in this organism.",384,1.0,-0.0999783,-0.02209428,-0.115085036,0.03966991,0.057015773,0.03428973,-0.065489285,0.051603295,0.060593173,-0.033001292,-0.011646978,-0.068980016,-0.058960438,-0.007394467,-0.050564744,0.019794526,-0.08733372,-0.034643833,0.001422461,-0.10749074,0.033880237,0.018126115,-0.019222088,-0.061523993,0.0024710672,0.055011738,0.014941604,-0.003334297,-0.08448775,-0.07694401,0.07607534,-0.0451035,0.060935296,-0.0045233504,0.04139991,0.07363437,-0.004444422,-0.1059604,0.034443602,0.026477514,0.0024368963,0.052327037,-0.054570742,-0.004351892,-0.041900776,-0.017772544,0.009779716,0.030077158,0.076937705,-0.046327922,-0.03464852,-0.035463918,-0.01659735,0.04016587,0.022494126,0.060330022,0.004709042,-0.038669366,-0.008597693,-0.04777776,0.02775555,-0.036184505,-0.0007134836,0.020438619,-0.040814202,-0.04570204,0.04902542,-0.12926237,-0.0056919763,-0.07913241,-0.13367423,-0.07388572,0.0020054688,4.013795e-05,-0.04426118,0.023563731,-0.0062686927,-0.043853447,0.07318913,-0.009745004,-0.045899555,-0.0038466419,0.015954604,0.06711657,0.019784415,-0.054984923,0.09046625,-0.036732107,0.005045367,0.06499925,0.0222702,-0.013666534,0.041458,-0.011283672,-0.05717323,0.048327237,0.0506089,0.08364221,-0.00026990334,-0.028005451,0.002121835,0.11928879,0.0151691735,-0.09335485,-0.054239962,-0.050297618,-0.008184673,0.14901881,0.05187446,-0.01235171,0.015081684,-0.006071659,0.017186292,-0.02728627,0.048332687,0.09287545,0.039768144,-0.026412217,-0.07501067,0.034174513,0.018962417,-0.05598512,0.048346184,0.041566294,-0.001810552,-0.021030413,-0.13016978,1.7794455e-33,0.09226334,0.020690689,0.009060893,-0.057128225,0.0014032784,0.023262078,-0.11196131,0.105674185,0.0032323392,0.009683631,-0.0451069,-0.06652137,0.054830287,0.0141256,-0.04036602,-0.04065223,-0.08995785,-0.029262539,0.02509227,0.029058812,0.008771488,-0.0007829479,0.009172376,0.048404373,0.022578394,0.0209331,-0.011133312,0.012782678,-0.027367797,0.03289459,0.011531868,-0.11371864,-0.1218886,0.018155301,-0.007640338,-0.03313412,-0.017921457,-0.012838074,-0.028039485,0.04195979,0.00093867606,0.02203224,0.068538584,-0.037730258,0.08293532,-0.043965638,-0.060835388,0.12668607,0.0914049,0.1329672,-0.013538296,-0.02392586,0.13443872,-0.035034157,-0.040808573,0.0759188,-0.07084283,0.027776381,0.059147187,0.025762716,0.064748,0.07601272,-0.03753787,0.03284038,-0.03734273,0.088820994,-0.038880546,-0.024076672,0.03659696,0.11682378,-0.04248199,0.065363996,0.055143233,0.018539267,0.014697683,-0.040352702,-0.03141768,-0.011070824,0.029086193,0.033885133,-0.077692606,-0.024909195,0.024408782,-0.04934787,-0.058213834,-0.024444742,-0.026584843,0.001902705,0.013277683,0.010372001,0.04475741,-0.052182727,-0.058278367,-0.047106344,0.006724433,-3.0322395e-33,0.08524011,-0.084846206,0.00411321,-0.11941224,-0.020890936,0.04055081,0.0075124786,0.07252937,-0.010657249,0.00019017454,0.100900024,0.064614125,0.04404281,-0.06759387,0.04275642,0.031062802,-0.03763258,0.035414327,0.007571931,0.040598705,-0.0060478505,0.020030025,0.03297077,-0.020334247,0.066642344,0.008877039,-0.05262324,0.0011945943,0.0746461,0.03874319,-0.012757256,0.0663072,-0.013421392,-0.031034846,-0.052531786,0.0051913396,-0.086784795,-0.025079053,0.016516242,0.014874882,0.024337599,-0.012788377,-0.04415968,0.061445583,0.05972104,0.054703012,-0.073852696,-0.004741558,0.029083963,-0.1174975,-0.027472826,0.018998064,0.014372752,0.0049917423,0.025193097,0.057270806,-0.04028285,0.014800875,0.009729961,-0.014105551,0.026355412,-0.07433221,0.064841285,0.031216614,0.046168387,0.0037859124,-0.045120988,0.048236236,-0.0065790806,0.024322547,0.03637342,-0.043252446,-0.0009571635,-0.007008359,-0.038014974,-0.061115272,-0.037937094,0.03244878,-0.038654394,0.039059293,0.038995065,0.007840916,-0.03712312,-0.05821075,-0.022127252,-0.03317749,0.0061818575,0.05496258,-0.04837276,0.04471088,-0.09358981,0.045643885,-0.049404047,0.04743082,0.021150984,-4.2358277e-08,0.017903915,-0.04864297,0.11753288,-0.008950356,0.07576319,0.09939139,-0.035836965,-0.014870966,0.006678035,0.008312875,-0.014129512,0.08155982,0.019070206,0.015565753,0.02020569,0.05835196,-0.07864877,0.013773043,0.013813742,0.027793726,-0.04524251,-0.015201602,-0.062473007,0.05895286,0.03212495,-0.039555643,0.019449743,-0.014631136,-0.045527183,-0.032865137,-0.0540552,0.048373017,0.008511329,-0.015470366,-0.07966017,0.012444598,-0.03922895,-0.04644102,-0.053620644,0.010024862,-0.0256448,-0.024573043,-0.07459008,0.04127154,0.079878114,0.026927486,0.04081509,-0.023139426,-0.0766553,-0.04436342,0.03808124,-0.0062854392,-0.012121498,-0.0036851508,-0.07089656,0.076490164,-0.03976432,-0.12638348,-0.0016527354,0.0020252755,0.025419777,0.037072994,0.11707836,-0.023193201 +1.14.15.36,"A cytochrome P-450 (heme-thiolate) protein found in several bacterial species. The enzyme, which is involved in sterol biosynthesis, catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond. The enzyme from Methylococcus capsulatus is fused to the ferredoxin by an alanine-rich linker. cf. EC 1.14.14.154, sterol 14alpha-demethylase.",384,0.99999994,-0.0768831,0.030294724,-0.06428392,-0.042614784,-0.011182879,0.048259545,-0.066778906,0.08598421,0.01250228,-0.038020972,0.03555483,-0.046022195,-0.015516344,0.061604485,-0.032786507,-0.023953432,-0.116855174,0.004150537,0.03398198,-0.047468808,-0.0012743357,0.066333696,-0.016268209,-0.020926578,-0.010361301,0.06432632,0.07906915,0.068264335,-0.0202402,-0.049092297,-0.016467432,-0.04374028,0.077137105,-0.07124838,0.043771368,0.12063142,-0.008020232,-0.06675781,0.077819504,-0.0048200046,0.03951672,0.004811522,-0.034459986,-0.003763754,-0.019683119,-0.030125668,0.04232428,0.014251409,0.027524265,-0.07469498,-0.0036742885,-0.062436752,-0.011303357,0.052452568,0.027196065,-0.013483313,-0.02401624,-0.09727744,-0.04213572,-0.0483904,-0.027488621,0.026984937,-0.05044792,0.011376245,-0.058481526,-0.0630767,0.015452234,-0.051847804,-0.023666965,-0.023540545,-0.07989689,-0.051471945,-0.02181476,0.06069783,-0.075233355,0.047957957,-0.014968996,-0.055591956,0.03768337,-0.0074803345,0.01650245,-0.04354032,-0.056354895,0.12606618,0.08510705,-0.07695104,-0.011493345,0.005929776,-0.057822935,0.032972094,0.016181007,0.057557322,0.053192113,-0.0159528,-0.1206731,0.034293767,0.029940315,0.020055618,0.022920655,-0.0140882125,0.009909894,0.077229075,-0.023703268,-0.06897162,-0.010019007,-0.030621076,0.0022216595,0.12257041,0.070222,-0.056830637,-0.016440375,0.010955465,0.042335894,-0.043006554,0.002377918,0.08801134,0.057709966,-0.04254098,-0.0688379,-0.03236385,-0.042489342,-0.056621905,0.056873213,-0.0047657085,-0.021676723,0.009637844,-0.11443443,1.3001863e-33,0.09849511,0.03846324,0.0043168794,0.022241056,0.0052082655,-0.0007272018,-0.04240701,0.046405926,-0.023746956,-0.042430244,-0.062089916,-0.097519085,0.038771305,0.012136077,-0.068032265,-0.010826323,-0.01120756,0.06758481,0.03788963,-0.024003519,-0.05656331,0.053508244,0.037868615,-0.049621362,0.04728926,0.05823091,-0.0073603564,-0.01990012,0.05121996,0.018370112,-0.043299384,-0.07395019,-0.1034405,-0.02758216,0.07725415,-0.0098186135,0.0100239385,-0.045257065,-0.05752035,0.06113705,0.0010201427,0.004867104,0.015927386,-0.08619273,0.076746896,0.028833855,-0.11083841,0.070238195,0.060072325,0.09774777,0.06518484,-0.012261311,0.0653351,-0.0029666557,-0.08479336,0.07826333,0.0041320315,0.053460047,0.014637344,0.057478897,0.08725721,0.11054285,-0.031917613,0.07054271,0.023029817,0.038165983,-0.0028199584,-0.070356,-0.050917204,0.15054877,-0.050341476,0.04769648,0.025528768,-0.021502927,0.018796666,-0.008531675,-0.052867282,0.034015052,0.12821522,0.018398033,0.00068199413,-0.010678166,-0.0058390023,-0.06302185,-0.017058264,-0.009577546,0.022884632,-0.0065628868,0.0011863988,0.040109873,0.021694722,-0.10088988,-0.046606995,0.011785814,-0.030653436,-2.3101798e-33,0.06962125,-0.12086097,0.048737668,-0.10633697,-0.039749846,0.032046277,0.00047226087,-0.012376781,-0.02371004,-0.018782372,0.1510225,8.377619e-05,0.026543189,0.028001003,0.0012957698,-0.008554533,-0.02836053,0.012714768,-0.030134575,-0.0047662454,-0.005026834,0.0006258375,0.023456516,0.059981037,0.023936613,0.012331232,-0.017128939,0.03672165,0.074760236,0.027960286,0.017147621,0.021539183,-0.030306775,-0.09727652,-0.08274829,0.07259728,0.023174187,0.0033158637,0.064096026,0.0050871344,0.005245374,0.0015213202,-0.0014312263,0.041407317,0.018447153,0.054315522,-0.03900089,-0.025227802,0.037444226,-0.00056863547,0.037891235,-0.0004330872,-0.0061300704,0.030126125,-0.041092835,-0.015922217,0.00871942,0.05016641,0.025094626,-0.07819684,-0.028865602,-0.056707874,-0.0044194553,0.056970082,0.02930034,0.0659759,-0.044899017,-0.03890763,0.038294315,-0.03359173,0.012050793,-0.025701966,0.04588256,0.05523949,0.0009851352,0.020932615,0.017090363,-0.064147815,0.01114365,0.02601868,0.005733992,-0.040724285,-0.018295258,-0.060827892,-0.07889274,-0.065623924,0.009171562,0.056270372,-0.021114048,-0.037250932,-0.038579762,0.053912368,-0.0733368,0.05881797,0.0012378654,-4.4017277e-08,-0.020846877,-0.078631245,0.032472678,-0.055763558,-0.00038182532,0.05558098,0.015365254,-0.048473813,0.08507742,-0.04716786,0.037949845,0.090797745,-0.031652767,-0.008300426,-0.00069344905,0.015382006,-0.06829461,-0.027724685,0.01682458,-0.05701859,-0.05879557,0.043951467,-0.0035749967,0.021467157,0.058434095,-0.06976531,-0.022040246,0.035692576,0.015238478,-0.035444807,0.03929766,0.050253097,-0.034294285,0.02409929,0.005191526,0.02141095,-0.06114883,-0.053254772,-0.03441165,0.054383654,0.035985224,-0.0072709345,-0.132834,-0.009088053,0.03674281,0.03808326,0.02911954,0.114789106,-0.03404376,-0.029100288,0.013350008,0.007127105,0.040768493,-0.07198695,-0.111284174,0.04503851,0.037401248,-0.08111475,-0.03516626,-0.011016443,0.04152591,-0.029126376,0.20694745,0.020410182 +1.14.15.37,"The enzyme, characterized from the bacterium Streptomyces thioluteus, is a bifunctional cytochrome P-450 (heme-thiolate) protein that catalyses both the hydroxylation of its substrate and formation of a furan ring, the final step in the biosynthesis of the antibiotic aureothin. In the bacteria Streptomyces orinoci and Streptomyces spectabilis an orthologous enzyme catalyses a similar reaction that forms spectinabilin.",384,1.0,-0.04252846,0.04026114,-0.13766538,0.008030675,0.02825932,0.031039517,-0.025203452,0.09787398,0.021486664,-0.026722463,-0.023064362,-0.051674474,-0.04702278,0.09288928,-0.06361793,0.0054664263,-0.061770238,-0.0362245,0.06435651,-0.055469472,0.09169157,0.05686763,-0.02749182,0.01707886,0.030732274,0.008090833,0.032492995,0.00045175635,-0.036647793,-0.03575166,0.017402451,-0.04859625,0.062107876,-0.010122115,0.06582411,0.084713385,-0.018062089,-0.06424201,0.08798884,-0.05866008,0.01935396,-0.004405162,-0.050834224,0.020312546,-0.060591612,-0.0110109495,0.034072228,0.047597293,0.02964025,-0.040795613,-0.061325785,-0.059627354,-0.09078498,0.062430173,0.027498003,0.06381902,-0.0064098067,-0.07288476,-0.02254674,-0.068986185,0.019259082,0.0027576962,0.010036655,0.025100617,-0.013907161,-0.022900444,-0.00342635,-0.050666098,0.026596632,-0.03148683,-0.045941163,-0.057929415,-0.0005160988,0.039939802,-0.013452792,0.07004797,-0.04589104,-0.010816702,-0.030364685,-0.04574149,0.057613686,-0.022284767,-0.06549196,0.14624709,0.047917046,-0.03903267,0.04476608,-0.0119869085,0.02249668,-0.015577678,0.025177676,-0.0040472164,-0.036633976,-0.05247551,-0.09163478,0.0055387197,-0.014345323,-0.029272031,0.073333286,-0.0095648635,-0.020213207,0.048253454,0.015506094,-0.07467429,-0.059438255,-0.004759495,0.0035002977,0.11749782,0.103404425,-0.053935856,0.0020245581,-0.0322265,-0.0014569162,0.0015921488,-0.011817753,0.07764987,0.04018904,-0.03806108,-0.03475299,0.0036545903,0.021184731,0.051162846,0.029579574,0.059339818,-0.01761156,0.01193692,-0.070256986,5.914958e-33,0.06940258,0.033119544,-0.010888607,-0.087691754,0.037121095,-0.0076256213,-0.09781816,0.010665298,-0.042035546,-5.7801335e-05,-0.08008662,-0.103145845,0.013574705,0.034194876,0.036275737,-0.0643993,-0.009223334,0.0652345,0.049940668,0.029726509,-0.0118315015,0.038888615,-0.053415466,-0.0018888164,0.055850793,0.115209855,0.0035258248,0.046498694,0.031241614,-0.015224489,0.03999373,-0.07179394,-0.06915077,-0.03460025,0.055624492,-0.049526915,-0.01215092,-0.025044682,0.050149933,0.017573226,-0.040743433,-0.014097007,0.042760357,-0.04579144,0.080102615,-0.04834656,-0.09449491,0.08661104,-0.0007635595,0.082752414,0.039767027,-0.086892895,0.11528276,-0.009467391,-0.07088419,0.031256482,0.017736213,0.0444877,0.051361773,0.020201266,0.10311169,0.034518406,-0.05052315,0.009261249,0.021178905,0.031676784,-0.0021727027,-0.014007817,-0.016284866,0.11006469,-0.10124419,0.06042737,0.020408412,0.020721566,0.007741301,-0.014453551,-0.064893425,0.037283976,0.037705522,0.034759376,-0.053679504,0.039752446,-0.00914643,-0.06025682,-0.021736447,0.057319924,-0.02341668,-0.03930125,-0.035901383,0.04244415,9.7378455e-05,-0.036123488,-0.05645047,0.011050073,-0.005003302,-5.7345658e-33,0.09560416,-0.13040231,0.03166036,-0.03100575,-0.07922964,0.06305008,-0.041719604,0.028848207,-0.038915087,-0.02166341,0.08652898,-0.026658984,-0.00859903,-0.050066095,0.005504062,-0.011144213,-0.039388835,0.055681136,-0.0017944265,0.032833837,-0.006755664,0.033076286,-0.016284822,-0.034233402,0.053527016,0.017757842,0.02713238,0.033116862,0.03806803,0.06535951,0.0013338712,0.0047639515,-0.09711917,-0.091594696,-0.051450882,0.11568362,-0.03350838,0.035356313,0.08718253,0.015734017,0.03171341,0.038634185,0.02759068,0.047411818,0.020024054,0.07090543,-0.049641166,0.02119024,0.0090255225,-0.062210783,0.017998468,0.037188195,0.022237258,-0.016988005,-0.023285797,0.010816782,0.012652396,-0.040646244,0.0032037932,-0.06137373,-0.023849405,-0.10953388,0.05763218,0.048276104,0.016276209,0.050686926,-0.085600145,0.010815951,0.08524564,-0.017640417,0.08694967,-0.030748527,-0.034091488,0.06252794,-0.008691427,0.0062888213,-0.04948303,-0.010304044,0.022234984,0.049917005,0.056651216,-0.010222994,-0.050910823,-0.061908796,-0.009777355,-0.08976957,-0.029436948,0.08998638,-0.033434175,0.028386632,-0.030149596,0.0454107,0.013246829,-0.0052031907,0.039558228,-4.254464e-08,0.010018827,-0.061410744,0.07225895,-0.013948149,0.043061662,-0.0064578764,0.017179431,-0.0903825,0.0058399667,-0.075367264,-0.053178262,0.0043246956,-0.046412554,-0.029008713,-0.0033750709,0.044413645,-0.017420925,0.021035083,0.016649483,0.0035586897,-0.05834773,-0.0019429917,-0.1434664,0.03762341,0.048228584,-0.04789916,0.033645444,0.009738323,0.0074411314,0.026719293,0.022069082,0.06709788,-0.027513035,0.005934713,-0.017088681,-0.013999727,-0.116064645,-0.030959563,0.0073402957,-0.04361928,0.018665275,0.018118544,-0.07967256,-0.028092392,-0.039196897,0.028473431,0.07152928,0.009978978,-0.082339786,-0.0041634375,0.053162094,-0.028840693,0.024189986,-0.01742979,-0.13731554,0.04576106,0.06570249,-0.07612658,-0.10159241,-0.03026873,0.04715243,0.008870904,0.22074959,-0.024588075 +1.14.99.65,"The enzyme, characterized from the bacterium Streptomyces venezuelae, participates in the biosynthesis of the antibiotic chloramphenicol. It carries an oxygen-bridged dinuclear iron cluster. The native electron donor remains unknown, and the enzyme was assayed in vitro using sodium dithionite. The enzyme only acts on its substrate when it is loaded onto the peptidyl-carrier domain of the CmlP non-ribosomal peptide synthase.",384,1.0,-0.05225809,-0.015411865,-0.15368472,0.023815364,0.038107824,0.0038567116,-0.04771539,0.050348908,0.07711666,-0.05599684,-0.0010489695,-0.07634719,-0.0042061144,0.058875874,-0.08348592,-0.015139528,-0.077300996,-0.0001897037,0.028472738,-0.021318879,0.06539105,0.024755659,-0.01097588,-0.039666176,0.010869669,0.06010699,0.06897574,-0.067589805,-0.02494594,-0.0718688,-0.012021708,-0.0073421225,0.08845336,-0.053827282,0.07704065,0.081097394,-0.02555301,-0.069157735,0.09892293,0.025258046,-0.017414773,0.0006882821,-0.018283732,-0.016114436,-0.055442464,0.011599329,0.0741486,0.10307852,0.006286504,-0.02076923,-0.017578743,-0.050556235,-0.043195806,-0.0014015227,-0.041342422,0.092969745,0.048119757,-0.046513204,0.024363121,-0.0648986,0.06447292,0.029260965,0.0013281839,0.015863826,-0.0908878,-0.07896245,0.0068865265,-0.07348296,0.033727247,-0.11060743,-0.053380646,-0.06820648,0.0067906734,0.035213314,0.020386057,0.019325523,0.09291549,-0.03575162,0.0010145708,0.011734118,0.030663569,-0.025162062,0.02178961,0.09530089,0.097127296,0.04359986,0.013167829,-0.011383215,0.03877973,-0.0023898208,0.02376351,0.0024528774,-0.07214696,-0.049160223,-0.08295394,0.028065087,-0.052394357,0.054618545,0.008779985,0.028887395,0.015556646,0.04766943,0.019408783,-0.03303318,-0.027722506,0.011439656,0.009735722,0.116580546,0.05549285,-0.04417688,0.022182643,0.04090484,0.017456323,-0.04336479,0.020781972,0.07968625,0.077763036,-0.0744568,-0.053791493,0.028952435,0.046173852,-0.019549442,-0.0026666955,0.06976323,-0.005735824,0.059878565,-0.12389096,2.5130504e-33,-0.0064364946,0.0320792,0.04117145,-0.03869251,-0.0257503,-0.015708921,-0.07502668,-0.030682199,-0.026577625,-0.07636916,-0.06507695,-0.103250146,0.042580634,0.0034050327,0.008106908,-0.063674256,-0.033595987,0.026923303,0.055548344,0.015417396,0.011528736,0.054220516,-0.016812138,0.050178908,0.05880273,0.08090823,-0.020039117,-0.019468654,0.12048853,-0.024027891,0.024693325,-0.032266423,-0.09898758,0.004130897,0.051022045,-0.0010881973,0.019420784,-0.03618224,0.019842613,0.04906323,-0.021271974,0.016560653,0.00095232343,0.0035095303,0.087673865,-0.097399585,-0.057093162,0.05996255,0.037246726,0.03538179,0.02976045,-0.02523508,0.060767848,-0.0135794645,-0.08482064,0.072450206,-0.021961227,0.012537791,0.07937431,0.06492969,0.026255637,0.044935144,-0.04377059,0.042798214,0.04577863,0.006545698,0.018612025,-0.062154997,0.04175416,0.07589896,-0.11032856,0.014879964,0.022139285,0.05006161,-0.0080925925,-0.040234186,-0.08230667,0.0021631552,0.11204968,0.018035093,0.027800245,-0.017030146,0.0017745978,-0.07792342,-0.045678634,0.030061062,-0.010608878,-0.11333655,-0.00910321,0.03362195,0.022242561,-0.04797146,-0.1306967,-0.0054625217,-0.005607442,-3.611184e-33,0.08694489,-0.13701425,0.049936354,-0.023809046,-0.111076005,0.024198014,-0.09675756,-0.03798692,-0.01261923,-0.009618708,0.08492739,-0.035629604,-0.02054598,-0.09192478,0.051451333,0.026166247,-0.017852863,0.06609002,-0.012706934,0.06302393,0.018558452,0.062428936,0.03727042,-0.007949791,0.00700902,-0.017393615,-0.041477792,0.032288853,0.10107744,-0.0033295373,-0.01063059,-0.013507522,-0.016952844,-0.054875597,-0.050245695,0.075040676,-0.077153355,0.056056444,0.12538633,0.00783213,0.014603956,0.0048304936,0.015398563,0.05395764,0.01723329,0.07344584,-0.06504419,0.0522999,0.022954386,-0.08273626,0.017612206,0.0012061654,0.00069371297,-0.020239182,0.025518514,-0.018030075,0.014193183,-0.016433505,-0.0066436804,-0.025259672,-0.015210331,-0.04883384,0.026121099,0.0022082294,0.071706936,0.012391599,-0.043179404,0.09445975,0.08911829,0.013824408,0.030476848,-0.010796793,-0.013508065,0.017730193,-0.023316566,-0.03296647,-0.08478071,0.019244418,0.006779353,-0.0061618234,-0.03529582,-0.016147956,0.031315457,-0.07275394,0.03435472,-0.11793608,0.039806817,0.03967719,0.022780856,0.048165515,-0.0761344,-0.01262242,0.028573612,-0.01304011,0.038446266,-4.2303487e-08,0.02558251,-0.038375363,0.037511487,-0.058667447,-0.0011744838,0.00441413,-0.024666114,-0.109157756,0.019038362,0.036866397,-0.040324103,0.02560835,0.0015758562,-0.024349403,-0.015611446,0.094665915,-0.025083305,0.018159198,0.024836328,-0.0039634644,-0.052606378,0.04453616,-0.11132279,0.048888866,0.028624332,-0.055933937,0.042019166,0.0034352504,-0.0314666,-0.014346694,-0.044359043,0.051032223,-0.00080214813,-0.035097454,-0.012460402,-0.0022773757,-0.080626294,-0.043743037,-0.013619483,0.020560151,0.03604542,0.03462708,-0.066302955,-0.00049200177,-0.055630527,0.022761086,0.008837372,-0.012256058,-0.018868782,-0.05370079,0.07861915,-0.0072907237,-0.0032638386,-0.03146368,-0.12310715,0.097177535,-0.01058628,-0.050345004,0.029747473,-0.044474576,-0.028346922,-0.020085536,0.13769087,-0.04443281 +2.1.1.353,"The enzyme, characterized from the bacterium Streptomyces thioluteus, participates in the biosynthesis of the antibiotic aureothin. An orthologous enzyme in the bacteria Streptomyces orinoci and Streptomyces spectabilis catalyses a similar reaction in the biosynthesis of spectinabilin.",384,0.99999994,-0.04437435,0.04903886,-0.1314584,0.0076121287,0.040509,0.048023563,-0.056903876,0.054958906,0.026865223,-0.017414983,-0.030464616,-0.073383175,-0.058316935,0.07921907,-0.04919501,0.014896689,-0.0761113,0.0042900383,0.04606119,-0.05909673,0.10341346,0.053873997,-0.020013947,0.027294869,0.055561803,-0.0103694545,0.013173107,-0.009948599,-0.00012664258,-0.028065262,-0.0007462852,-0.086868234,0.06566743,-0.01879939,0.07099868,0.06951276,-0.006818294,-0.0336729,0.09979605,-0.039688956,0.005702454,-0.0031422535,-0.056433715,0.0122790495,-0.042995818,-0.0068076304,0.032858267,0.04931128,0.008808308,-0.0034345412,-0.08227052,-0.031856917,-0.08265878,0.07724495,0.060511667,0.08797149,-0.0071548675,-0.06594167,-0.03772929,-0.0722901,0.042640854,-0.041712288,0.024308635,0.04285277,-0.04725316,-0.017322546,-0.0030977011,-0.039989997,0.017043658,-0.039791197,-0.031582374,-0.03947464,0.010280379,0.06630684,0.046070732,0.04800893,-0.040686216,-0.008511064,-0.032640744,-0.06438931,0.08276039,-0.030887978,-0.061709575,0.1255862,0.025049519,-0.056178592,0.05488377,-0.02183407,0.032721903,-0.0047668475,0.040506124,-0.052681245,-0.007131834,-0.09325487,-0.059098516,0.010360879,-0.02490494,-0.057753354,0.08612891,-0.015471024,-0.038723115,0.037113167,-0.015799684,-0.06716644,-0.019871065,0.025021719,-0.03431554,0.07634182,0.067197986,-0.013017254,0.032537658,-0.018120222,0.026638016,0.048396017,-0.047546644,0.042670816,0.047714543,-0.036427654,-0.029575754,0.0105607705,0.04154401,0.030334463,0.033456657,0.115742356,-0.0040070354,0.016152222,-0.06548762,5.6426605e-33,0.056560237,0.021626573,-0.02653541,-0.12442647,0.051717475,-0.021833299,-0.08688006,0.025744222,-0.020947622,-0.019096673,-0.07099375,-0.11055802,0.015642846,0.06694595,0.04222734,-0.06395877,0.022029072,0.034549672,0.011944807,0.019123469,-0.0016470676,0.07003648,-0.09222222,0.038388465,0.053651445,0.09365547,0.023401301,0.059854347,0.025560653,-0.03294381,0.04789636,-0.078550905,-0.061908502,-0.013520747,0.06689619,-0.045915507,0.0062659555,-0.05074171,0.050318692,-0.008961477,-0.024179509,0.028967254,0.022083616,-0.032778632,0.061203204,-0.061176762,-0.055184398,0.0971463,0.04387603,0.069804184,0.03186108,-0.07156792,0.10747498,-0.011197489,-0.03576356,0.032882456,-0.017564202,0.038158823,0.04780514,-0.0042058113,0.04618862,-0.012269725,-0.028390037,0.01569142,0.0036580213,0.023216896,-0.011247861,-0.013815201,-0.03726296,0.062116418,-0.0918514,0.043620683,-0.011910971,0.03632499,-0.025226226,0.00049875135,-0.073695086,0.013826848,-0.008306244,-0.015493734,-0.06321684,0.03265766,-0.020112637,-0.051208973,-0.03324907,0.05047912,-0.05271282,-0.05128503,0.002945205,0.0027534307,0.0036856385,-0.019149115,-0.092606194,0.04289586,-0.00095935963,-6.217446e-33,0.07645667,-0.12661125,0.042977054,-0.01251266,-0.07076901,0.055227544,-0.084600374,0.01894105,-0.026256714,-0.038459424,0.031276252,-0.02110792,-0.008551535,-0.05987163,-0.006155364,-0.011474982,0.0027016068,0.0835231,-0.018276911,0.029222323,-0.015204673,0.046288617,-0.0057423026,-0.055983234,0.07387428,0.020704849,-0.011008864,0.054306403,0.0007086741,0.09667114,0.011565915,-0.00018307297,-0.09127606,-0.09057234,-0.046468567,0.10934109,-0.02905209,0.015329068,0.06988096,0.029747322,0.07594119,0.013569176,0.04186874,0.042124182,0.006775293,0.057743832,-0.05468066,0.03790308,0.017924786,-0.07541597,-0.005820388,0.03215847,0.068575025,-0.016518043,-0.0069784382,0.016573638,0.033882525,-0.058859013,0.036258526,-0.06921152,-0.00066701364,-0.10044234,0.077618994,0.0282242,0.0076577067,0.07137769,-0.101469465,0.043118723,0.08197104,-0.017525204,0.090974934,-0.050331667,-0.05287333,0.056074716,-0.025315292,-0.0017858358,-0.08490634,-0.04636507,-0.00027777048,0.046720456,0.011063477,0.019454056,-0.044706155,-0.045230143,-0.06620362,-0.04513819,0.00011993637,0.104011424,-0.056130923,0.06756701,-0.01295323,0.031553514,0.0024565859,0.01380806,0.026246171,-3.6683467e-08,0.03442582,-0.037011683,0.091707535,-0.026235782,0.010957017,-0.036991674,0.0074537867,-0.050025605,-0.008173865,-0.06702663,-0.07053939,-0.00035283656,-0.027908739,-0.020276714,0.010011157,0.0437631,-0.020112092,0.017088955,-0.020143054,0.011809181,-0.050548993,0.0017847986,-0.14937803,0.04972423,0.0346084,-0.024501165,0.027352607,0.016000189,0.00090404315,0.043890867,0.008278127,0.07915688,-0.008679209,-0.01749557,-0.045485575,0.00929641,-0.08326309,-0.05250204,0.035004057,-0.067462325,0.011626744,0.02578102,-0.059246026,-0.00036722445,-0.046853486,0.011520862,0.08449048,-0.008004821,-0.06474702,-0.021234691,0.05493851,-0.046861622,0.009682024,0.0071711405,-0.12873423,0.021518238,0.024805177,-0.05770287,-0.055861413,0.004472063,0.03166522,0.015875923,0.24170972,-0.025446007 +2.3.1.281,"This polyketide synthase enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), catalyses the first reaction in the biosynthesis of coelimycin P1. The enzyme is made of three proteins which together comprise six modules that contain a total of 28 domains. An NADH-dependent terminal reductase domain at the C-terminus of the enzyme catalyses the reductive release of the product.",384,0.99999994,-0.05365059,-0.026584247,-0.16027947,-0.02997658,0.024683895,0.0018263597,-0.07728657,0.048729848,0.07362118,-0.05160624,-0.012915788,-0.058918912,0.056182843,0.0015794769,-0.048693746,-0.023018835,-0.08071274,0.0016610045,0.07614894,-0.103288054,0.10956742,0.051677924,0.047820605,-0.009015114,0.037805676,-0.016281407,0.057566345,-0.020002225,-0.035731096,-0.0710287,0.01916624,-0.04560483,0.019175682,-0.046247717,0.10138356,0.11793567,-0.069874205,-0.05245174,0.07501687,0.012142856,0.04110171,-0.02434131,0.019999756,-0.0034135485,-0.020273622,0.03855809,-0.030668592,0.041940887,0.04783309,-0.057503182,-0.030578459,-0.028821278,-0.055997074,0.042271364,0.10499078,0.024738466,-0.023622781,0.016015356,0.016979488,-0.07182351,0.06425787,-0.021419343,0.010131726,-0.014545235,0.005779164,-0.036027353,0.028109767,-0.061316237,0.014273369,-0.029960565,-0.14394255,0.022697993,-0.040831722,0.0260087,0.0071504093,0.004608913,-0.09515253,0.010403397,-0.021378774,0.011353905,0.082011476,-0.016065095,0.030957373,0.078523725,0.028901292,0.010520635,0.030493049,0.0027470284,0.050021067,0.041797884,0.019907176,-0.034882814,-0.026736332,-0.0006799749,-0.12548387,0.014072582,-0.046206,-0.01799519,0.06370669,-0.0053533325,-0.043018393,0.045893542,0.095029734,-0.029353477,-0.05945172,0.006457333,-0.07197852,0.10540563,0.06497045,0.0040260414,-0.052301344,-0.0047298796,0.031815212,-0.06533589,0.0034091678,0.13980897,0.046706945,-0.026208514,-0.02690658,-0.015268868,0.024822168,0.0046361657,-0.008345049,0.046580195,-0.0051975385,-0.031838506,-0.1832039,3.141343e-33,0.039054878,0.06446212,0.03512064,0.0077529578,-0.005567168,0.0058041885,-0.042592246,0.0061166906,-0.07041832,-0.021856347,-0.043849498,-0.11837867,0.012126244,0.06364017,0.05570831,-0.058325652,0.012921053,0.012891087,-0.0038377298,-0.020256609,-0.016522413,0.010604769,-0.016981123,0.0017175025,0.05013283,0.020322282,-0.014635789,0.026234142,0.045121685,-0.03633593,-0.026126234,-0.03939716,-0.090209804,0.056768324,0.03480966,-0.046141714,-0.043078497,-0.06576653,0.056503367,0.08081291,-0.024552606,-0.027150378,0.02038789,-0.03772612,0.070961945,-0.0430686,-0.01657718,0.068007275,0.045579977,0.12088018,0.069426015,0.0010956996,0.07875804,-0.008047658,-0.075432315,0.037081655,-0.03590914,-0.014452515,-0.00519194,0.03807923,0.011341632,-0.007884639,-0.04682995,0.017197,-0.024815502,0.05896642,-0.050323565,-0.03799788,0.036266766,0.08118572,-0.08651097,0.0038984683,-0.0076039666,0.019998888,0.04706824,-0.011449253,-0.040037755,-0.010746401,0.053745598,-0.00085032906,-0.04372402,0.0353476,-0.029970376,-0.017284365,-0.04259382,0.01885798,0.00477877,-0.093359455,-0.008158441,0.07190419,0.021093043,-0.100517124,-0.006375362,0.057509474,0.0398447,-4.087189e-33,0.10844271,-0.080731004,0.048193987,-0.12678535,-0.038274854,0.025926946,-0.01573656,-0.010772139,0.0047356784,-0.058585227,0.05710985,0.007480584,0.012601226,-0.027050877,0.021754233,-0.0019434394,0.048120964,0.09619752,-0.0321654,-0.0028776978,0.044873245,0.074925564,0.00785159,-0.03536993,-0.018402405,0.021530816,0.007498794,0.08923515,0.0601592,0.050825663,-0.052909385,-0.059924945,-0.0106601585,0.06478584,-0.03436344,0.0447258,-0.08250194,0.010019809,0.07408615,0.03455623,0.06676027,0.0237711,-0.029587205,0.04538476,0.062534176,-0.012786699,-0.015495522,0.006783942,0.072438285,-0.10600759,-0.0069867573,0.03203649,0.043302916,0.003473856,0.002783315,0.005494274,0.03488543,-0.01465478,0.0011088194,-0.074912496,-0.046958674,-0.03477337,0.062352687,0.059589427,0.07122577,0.015473987,-0.003460682,0.024471728,0.050829887,0.026467986,0.11137049,0.030559642,-0.011495338,0.05653033,0.024363602,-0.096378736,-0.13347425,0.015791075,-0.04900673,-0.0054070386,-0.006791763,-0.040258188,0.010842347,-0.085964195,0.0005471066,-0.06547418,0.045908745,0.019084588,0.035113044,0.024719544,-0.004613304,0.068769775,0.0066102403,0.09736046,0.041757993,-3.787872e-08,0.042044654,-0.051226318,-0.015530217,-0.048294332,0.053436536,0.04301398,-0.00040300676,-0.091848046,-0.052545294,-0.02719534,-0.052287813,0.04742128,0.022841973,-0.006980174,0.030973794,0.024956584,-0.057465203,0.0006755313,-0.0067683985,-0.0439502,-0.100677036,-0.009310053,-0.09583391,0.020371577,0.021787535,-0.045493133,0.029660014,0.017387498,-0.0045628413,0.023411585,0.0029556141,0.033329226,-0.026694858,-0.04547244,-0.041141726,0.008479571,-0.024002321,-0.040587105,0.027184656,0.02045827,0.04656305,-0.0070032375,-0.03195797,0.028018525,-0.011186725,0.043304846,-0.009184277,-0.07593152,-0.070035495,-0.017170489,0.07021068,0.031442568,-0.021559227,-0.020883702,-0.11751484,0.05053606,-0.041306045,-0.028791377,-0.06458008,-0.053015467,-0.044797637,-0.012319485,0.1907288,-0.027083678 +2.3.1.282,"The enzyme, present in certain pathogenic species of mycobacteria, catalyses the transfer of mycocerosic acids to the two hydroxyl groups at the common lipid core of phthiocerol, phthiodiolone, and phenolphthiocerol, forming dimycocerosate esters. The fatty acid precursors of mycocerosic acids are activated by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, which loads them onto EC 2.3.1.111, mycocerosate synthase. That enzyme extends the precursors to form mycocerosic acids that remain attached until transferred by EC 2.3.1.282.",384,1.0,-0.07030471,-0.07061373,-0.0535756,-0.014446621,0.029132819,-0.00033425985,-0.033461746,0.09008545,0.029274832,-0.016271265,0.027305564,-0.09191707,-0.011604287,-0.011707133,0.011727977,0.0016561945,-0.019140312,-0.01108415,0.0032454247,-0.008964475,0.05877864,0.100693524,0.023105208,-0.014702672,0.016827617,0.0005253337,0.059017528,0.029839817,-0.028511196,-0.07349798,0.013427317,-0.13900818,0.06696516,-0.03732288,0.06902497,0.076438606,-0.007866808,-0.10128742,0.07547054,0.02218773,0.06365739,-0.042418785,0.030194068,-0.0025938204,0.0009852245,0.020977031,-0.068870895,0.05151331,-0.024153622,0.0048065735,-0.04043632,-0.07056276,-0.08345783,0.025185369,0.0012829294,0.032528255,-0.04001152,0.0219033,-0.008448105,0.06096051,0.052408207,-0.008454715,0.059269574,0.050221708,-0.08302696,-0.07216596,0.022165349,-0.027536226,0.083103545,-0.023649227,-0.095495716,0.0038047908,-0.009475567,0.07741141,0.027134212,-0.021013808,-0.014959611,-0.026524108,0.012804638,-0.0227074,-0.029144017,-0.012224217,-0.07953805,-0.01691112,0.02221983,-0.05634026,0.117624864,-0.03358653,-0.031366814,0.089643985,0.09860628,-0.10418716,0.018687645,-0.009734347,-0.036153376,-0.0038205571,0.10456847,0.022581303,0.05717765,-0.066120595,8.383167e-05,-0.03230068,-0.053735867,-0.028328663,-0.02052911,0.026629325,-0.04654576,0.03351538,0.019040303,0.06295052,0.00786798,0.0072672814,0.020506268,-0.040440157,0.010358905,0.08392306,0.02350043,-0.08394476,-0.075150505,0.020856174,-0.030139325,-0.11779909,0.045659773,0.019530248,-0.113766745,0.017338576,-0.07635074,4.532342e-33,0.011028043,-0.019969534,-0.024387604,0.012772585,-0.023105081,-0.06935598,-0.11046917,0.030690294,-0.07179683,-0.08715684,-0.0014344668,-0.03505136,0.037594218,0.07021186,-0.110314064,0.029712742,0.007599881,0.03371342,0.09105252,0.030388841,-0.0052233925,-0.031864796,0.06312249,-0.030750819,-0.0125892125,0.08010994,-0.07593882,0.008998905,0.028401932,0.0010825603,-0.0040707355,-0.09854896,-0.02881943,0.0105154505,0.01737133,0.020225937,-0.021415697,-0.1084959,0.0584295,0.017999344,0.0022900258,-0.0057503846,0.04341647,-0.021819454,0.06731642,-0.020572525,-0.039396822,0.073101744,0.017042635,0.030320462,0.008530183,-0.09462797,0.078976594,-0.0024114358,-0.022060726,-0.089824125,-0.07334938,-0.013444116,-0.01912444,0.024182301,0.07841336,0.13318536,-0.048877392,0.09018299,-0.04670637,-0.051974017,-0.08941508,0.03070475,-0.0068440586,0.037197117,0.04109664,-0.010585937,-0.0067569907,-0.03494596,0.08273998,-0.037690863,-0.054062255,-0.029008424,-0.041128468,0.0022161878,0.079858385,0.07366804,-0.010990152,-0.035030425,-0.026516076,0.014001082,-0.06007268,0.0005683223,0.017008394,0.020095559,-0.08134013,-0.07199345,0.008041381,0.096546724,-0.023520749,-5.9950366e-33,0.14760837,-0.056157295,0.10060115,-0.085295945,0.0063918736,-0.015725762,0.092908226,0.03823458,0.033859555,0.012268002,0.056073915,-0.043824255,0.03567856,-0.050117213,0.025658706,-0.020793531,-0.069622375,0.0013460558,-0.052946463,-0.042435568,0.021666102,-0.00017033584,-0.024880668,0.04849342,-0.022016518,-0.015871972,-0.082253195,0.06772467,-0.0017274625,0.072237514,-0.014833639,-0.029813891,-0.08464406,-0.031477805,-0.05543773,-0.022502663,-0.07496575,-0.01570911,0.045664776,-0.019273456,0.039430745,0.07028177,-0.021371698,-0.039467745,0.00066152913,0.024993319,-0.017598875,0.02742873,0.030349685,-0.07910829,-0.05124466,0.0007556627,0.011849848,0.052097864,0.020099305,0.11773698,0.022047056,0.04028574,0.04002675,-0.1091091,-0.069402464,-0.0744308,0.045123845,-0.018985676,0.050968815,0.06725757,0.035249013,0.07108727,0.04390251,0.017859682,0.0077932402,0.0452933,-0.057934202,-0.03125989,-0.03980445,-0.04093664,-0.03238879,-0.0041560507,-0.014224212,0.013600547,0.03452795,-0.01509588,0.020647831,-0.118326925,0.013117816,0.0013089785,0.043580335,0.07010487,-0.06397876,0.06919818,-0.009319777,0.0258847,-0.018429246,0.0039709834,0.011958711,-4.058406e-08,0.041809086,-0.022480818,0.06149462,-0.009675263,0.046029605,0.028293708,-0.023729166,0.032317415,0.056833263,-0.022479195,-0.0036290404,0.049026974,0.07373544,-0.030747714,0.047136698,0.04104751,-0.08022426,-0.033002697,0.017689113,-0.07270853,-0.05834463,-0.048892114,0.011153157,0.06190501,0.032871418,-0.036739167,0.048296742,0.0795147,-0.035405796,0.019023374,-0.0026804786,0.008011834,-0.037241343,-0.019313348,0.0019234215,0.007939023,-0.044786554,-0.033253398,-0.07022593,0.09774535,0.06081395,0.018606124,-0.07844799,0.051631887,0.057430707,0.018174628,-0.019776156,0.02584464,0.00048826443,0.05464521,0.025582504,-0.024612332,-0.035586562,0.019468935,-0.04026992,-0.018268988,-0.045292135,-0.007580708,-0.08312196,0.022160731,0.06126846,0.041684307,0.16837873,-0.01942218 +2.3.1.283,"This mycobacterial enzyme catalyses the acylation of 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose at the 3' position by a (hydroxy)phthioceranoyl group during the biosynthesis of mycobacterial sulfolipids.",384,1.0,-0.0643685,-0.07774354,-0.14961271,-0.02881527,-0.07858646,-0.032899663,0.0009527932,0.0076047075,0.010921151,0.018520039,0.03999754,-0.035263743,-0.045299355,-0.00981286,-0.021106541,0.06865103,-0.03822326,0.051275365,0.02161355,-0.0430002,0.085398406,0.05034881,-0.0010094573,-0.059170697,0.047207925,0.06316918,0.016296802,0.004943508,-0.05320862,-0.06509672,0.012476568,-0.04297449,0.06022457,-0.05521139,0.117012106,0.05659609,-0.044363853,-0.08613942,0.105600335,-0.0119527485,0.04321856,-0.0079791695,-0.006799411,-0.0166714,-0.0100991335,-0.012924406,-0.045698646,0.079460315,0.024820779,-0.075276114,-0.06821241,-0.006413833,-0.07130536,0.032005273,-0.0052080834,0.07787959,0.030769663,-0.008898069,-0.004441388,0.02387909,0.038887516,-0.015311294,-0.032305557,0.05819035,-0.056199227,-0.07679146,0.016359001,-0.060253836,0.036625482,0.027911402,-0.11184811,-0.01925664,0.02324763,0.059807576,0.0016675588,-0.026916318,0.039492156,-0.04404976,0.059182074,0.0081846295,0.027634636,-0.023962641,-0.034391716,0.03479046,0.03943305,-0.11919508,0.09899121,-0.019956866,0.096835434,0.10284921,0.066620775,-0.05685963,0.04204248,-0.06801901,-0.043471638,0.02517138,0.0862564,-0.0017030674,-0.014639162,-0.022788608,0.028702471,-0.058621082,0.024882043,-0.10471975,-0.04887166,0.040537596,-0.04721378,0.06681775,0.038586993,0.0838571,-0.0687959,0.01003932,0.010661211,-0.04437109,-0.047022942,0.124702215,0.04972248,-0.041516006,-0.063263595,0.0062264972,-0.0033034268,-0.045986865,7.1166345e-05,0.0432675,-0.07101541,0.041623157,-0.09119763,1.4804479e-33,0.06826161,0.094372466,0.02830451,-0.08220319,-0.014224675,-0.08460332,-0.15975426,0.005681817,-0.054491445,-0.021979598,-0.015803494,-0.07317883,0.006355695,0.07051801,-0.055086218,0.026663706,-0.014622703,0.06928511,0.04623773,0.0075217555,-0.055321857,0.014158482,0.00679401,-0.023165397,-0.010313618,0.014305255,-0.021028657,0.0064720763,0.014180998,0.04142479,0.09958078,-0.07597658,-0.03480031,-0.045078684,0.06532915,-0.020891882,-0.03327843,-0.08695748,0.03942523,0.052236892,-0.017745677,-0.03159912,0.054516874,-0.012715124,0.03409563,-0.08002992,-0.06714342,0.04720884,0.011292697,0.06542854,0.0018165283,-0.065767534,0.054023694,0.058076967,-0.018151445,-0.038904116,-0.04297821,-0.014574132,0.049410958,-0.016779603,0.022824926,0.051049028,-0.0463786,0.0036040065,-0.10942576,-0.045463517,-0.013660209,0.047312934,-0.005474805,0.04390712,-0.035957243,-0.05589482,-0.015449988,0.0059269983,0.06646693,-0.010821249,0.034902748,0.030268429,0.0003522212,-0.01089621,0.009472453,-0.011899149,-0.011552591,-0.002567091,-0.024280101,-0.042946693,-0.09257367,0.01064037,-0.033899836,-0.0015485726,-0.052967526,-0.028069068,-0.042872343,0.091570385,0.00445842,-4.4927104e-33,0.08407468,-0.11811081,0.08326717,-0.14763294,-0.056502417,-0.044069137,0.03681106,0.014619964,0.02106183,0.018027047,-0.01573209,0.0020954504,0.043749712,-0.0834021,0.00511421,0.0025392242,0.053371627,0.03917557,-0.02323576,-0.034218505,0.05278946,0.06528686,0.039327838,-0.010776408,-0.01311821,-0.013423019,0.012147653,0.028927473,0.043290686,0.13112451,0.02748257,-0.06424895,0.0059494074,-0.032970544,-0.059019126,0.01673013,-0.06613065,-0.025152588,0.018042743,0.04916711,0.00948261,0.027973,0.039530627,-0.0017615166,0.029013302,-0.049235564,-0.05666251,0.0016044297,-0.033725556,-0.08349113,0.0039756596,0.07400301,0.034870908,0.01790564,0.01514097,0.039833747,0.015661836,-0.059244346,-0.012862838,-0.07152962,-0.072950356,-0.013814969,0.03722266,-0.059857063,0.082235,0.08814423,0.012052987,0.036282416,0.02840053,-0.05466539,-0.010050463,0.018055813,-0.07210446,0.013657179,-0.0055946345,-0.032029346,-0.06161888,0.044522382,-0.007447343,0.02402767,-0.006851845,-0.00046521076,0.05988776,-0.0924354,-0.048676196,-0.07117416,0.02271512,0.11549339,-0.025157642,0.05662133,-0.030662686,0.043505613,0.0028720475,0.057974398,0.049802642,-3.4802014e-08,0.0167255,-0.029235674,0.09214916,0.023151984,0.02265,0.1019912,-0.070566714,-0.024112279,0.067824036,-0.045780003,-0.021291722,0.08841816,0.071415804,0.014270037,0.036423218,0.045971904,-0.08175142,-0.07978011,0.001536406,-0.06016616,-0.036365453,-0.0043183533,-0.029036881,0.053325314,0.04095776,-0.02368062,0.017440056,0.0058875745,-0.06724231,0.026127981,0.026322132,0.048439015,-0.06394102,-0.015849425,-0.03856178,0.008257615,-0.050504632,-0.1192503,-0.005149926,0.027016016,0.034461938,0.023617836,-0.052037645,0.08227082,0.003248749,0.059465025,0.026265766,0.031678423,-0.043606624,0.040062785,0.042699136,0.01419218,-0.089676656,-0.030423589,-0.028601114,0.03262546,0.022177078,-0.014635117,-0.023681343,0.024425361,0.07433546,0.0043862746,0.10369462,-0.026399897 +2.3.1.284,"The enzyme, present in mycobacteria, catalyses the ultimate step in the biosynthesis of mycobacterial sulfolipids. It catalyses two successive transfers of a (hydroxy)phthioceranyl group from two diacylated intermediates to third diacylated intermediate, generating the tetraacylated sulfolipid.",384,1.0,-0.07793568,-0.02741412,-0.09885532,-0.033528797,-0.043165553,-0.010621913,-0.009838444,0.033415716,0.04021548,0.0033870824,0.004589446,-0.023739627,0.018132884,0.0076483516,-0.028972022,0.08905496,-0.076994985,0.094675116,-0.040312003,-0.053868547,0.07078595,0.039019,-0.0078081507,-0.03459572,0.027741227,0.098562256,0.022924503,0.029220827,-0.048666548,-0.069123,0.048225325,-0.02408831,0.017455887,-0.06340717,0.094256684,0.07391636,-0.04665771,-0.060114983,0.103004724,-0.012361172,0.04293127,-0.04166164,-0.022622114,-0.03235519,-0.012150051,0.00858245,-0.03426167,0.071827486,0.011393972,-0.10379039,-0.09989398,0.005451756,-0.08258917,0.07600222,0.012524712,0.041230712,0.011643451,-0.020440504,0.03877772,-0.019932404,0.011086826,-0.004512646,0.009510995,0.050609015,-0.020855362,-0.0907095,-0.004928776,-0.042859793,0.027262172,0.028399205,-0.11762849,-0.0036410599,-0.034078285,0.063163795,0.025934879,-0.0061667147,0.01153013,-0.018136954,0.03485754,-0.015708486,0.0023938485,-0.026949242,-0.007640036,0.029142458,0.06285697,-0.07630219,0.09561987,-0.018087441,0.09302572,0.084108435,0.06076756,-0.07197952,0.035409536,-0.075926006,-0.038907625,-0.012497498,0.07125496,0.033970553,0.030068465,-0.0035827125,0.03271332,-0.04514097,-0.014999456,-0.08347639,-0.005525337,0.019101568,-0.013255555,0.07929572,0.05894945,0.03820964,-0.07812733,-0.02484172,-0.0007720083,-0.04331653,-0.0323331,0.115985736,0.06465779,-8.578585e-05,-0.078453146,0.019685842,-0.001670201,-0.060165804,-0.007689645,0.019672357,-0.11067809,0.059343334,-0.12468181,3.8070342e-33,0.08155083,0.064236335,0.021011397,-0.061583,-0.053122766,-0.05687985,-0.1500546,0.016838452,-0.007895828,-0.06406044,-0.06464727,-0.04419343,0.008238952,0.046886824,-0.07398687,0.006627043,-0.023675453,0.041224185,0.07476616,0.023848176,-0.052385055,-0.030358281,0.011992586,-0.040181715,-0.0020349391,0.07960929,-0.028717838,0.012910087,-0.018183371,0.03626721,0.07842033,-0.11418771,-0.07152869,-0.025193313,0.040811434,-0.026773019,-0.026669228,-0.112048484,0.056049306,0.025206953,-0.06712259,-0.043625172,0.049212582,-0.009247255,0.012489345,-0.0287325,-0.035332378,0.06764874,0.024898814,0.064857565,0.01557833,-0.058479663,0.06976909,-0.039282326,-0.030548465,-0.043039426,-0.017201917,-0.035865832,0.038062736,0.033314567,0.0056583923,0.06443677,-0.029431036,0.048454404,-0.030911889,-0.034297965,-0.024764836,0.04212291,0.03590113,0.041019935,-0.051611066,-0.049318053,-0.0024126442,-0.0027817974,0.0711605,-0.020477982,0.015689408,-0.052893877,0.02649564,-0.00888831,0.0034175555,-0.008004911,-0.048856866,-0.022524463,-0.014937591,0.0014522301,-0.0831259,-0.056547295,-0.058598753,-0.003389756,-0.044929434,-0.0557638,-0.028182002,0.055805206,0.0071436088,-6.39595e-33,0.08572496,-0.067774266,0.049556304,-0.11696151,-0.037793644,-0.05098626,0.054387007,-0.039104145,0.025710026,0.050590616,-0.03056475,-0.027081452,0.049112707,-0.049850546,-0.002146734,0.014173472,0.047347076,0.027146958,0.011542466,-0.03219364,0.04314865,0.074682035,-0.0033818525,-0.017238658,-0.0342265,0.012137685,-0.012359855,0.020770764,0.06812717,0.110791236,0.009454111,-0.03269628,-0.013184088,-0.0604566,-0.02199358,0.06584315,-0.08085817,-0.036243893,0.07174751,-0.003692324,0.015973788,0.01386437,0.046004176,0.038632523,0.014343827,-0.029651832,-0.04661315,0.07696766,-0.0008804653,-0.05851029,0.016950767,0.10612927,0.03256672,0.020193648,-0.0066505563,0.040148873,0.019135788,-0.034864802,-0.032501325,-0.0865807,-0.09328119,-0.04323271,0.05019137,-0.038483888,0.032995384,0.08822646,0.012505727,0.014738432,0.032314055,-0.07601533,0.03296397,-0.0060821516,-0.049976923,-0.039147716,-0.028162183,-0.008578746,-0.035858966,0.01891294,-0.016286433,0.06461366,-0.0066391816,0.027504005,0.05181117,-0.13903198,-0.02200203,-0.11195615,0.02828115,0.062904306,-0.022269754,0.010768272,0.028524617,0.064496286,-0.0018772844,0.07097456,0.035769336,-3.499123e-08,0.0028315545,-0.04544322,0.09338608,0.030295596,0.089343406,0.06124842,-0.07282064,-0.008936813,0.039275166,-0.0032885137,0.013271094,0.085102394,0.061932866,-0.010587018,0.09427477,0.07472539,-0.060520064,-0.07333715,-0.009962582,-0.047072016,-0.02122711,-0.014388565,-0.04731785,0.023950156,0.05116539,-0.052938987,0.041646563,-0.01810325,-0.045460258,0.029824879,0.057832368,0.06036549,-0.102757886,-0.019980254,-0.034208413,-0.0059092366,-0.06490814,-0.07996245,0.009133055,-0.0071920846,0.024058156,0.018560149,-0.092196755,0.07838072,-0.026959835,0.06981714,-0.03926983,0.029034546,-0.07632518,0.053853072,0.043283444,-0.020706357,-0.027472256,-0.034995187,-0.043307375,0.04524099,0.028869575,0.0049469317,-0.037765853,0.02126392,0.048122555,0.05040806,0.15695158,-0.044520903 +2.3.1.285,"The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.",384,1.0,0.028386822,-0.004425603,-0.09635473,0.010593557,0.030045101,0.08346836,-0.06808854,0.046061445,0.06817627,-0.08793833,0.028173015,-0.0012374392,-0.032407466,-0.040776346,-0.037456553,0.019344028,-0.07340375,0.0370573,0.02566771,-0.038339194,0.036440287,0.028704995,0.051243514,0.03258431,0.010143648,0.0733145,-0.04858425,-0.0089348415,0.046625074,-0.07468144,0.07493793,0.015830098,0.013280946,-0.038497522,-0.063648075,0.038134206,-0.06742112,-0.010247411,0.109221,0.043081265,0.07952477,-0.05843749,-0.07462485,0.022907322,-0.018048152,0.021387368,0.00073519174,0.034866985,0.028425125,-0.021020764,-0.025455805,-0.06690524,-0.067027174,0.06527406,-0.015667245,-0.012325103,0.03512686,0.021209467,-0.02745011,0.058752164,-0.011076733,0.062097583,0.02525266,0.040374298,0.059168432,-0.020245222,-0.0032238518,0.007264759,0.07988552,-0.03891499,-0.01097218,-0.08233014,0.008026108,0.016845888,-0.07109184,0.07332511,-0.084499486,0.029930936,-0.018088702,0.0046356902,0.106852666,0.034007333,-0.01568728,0.09747714,-0.014708801,-0.018296888,-0.03860012,0.035807576,0.05528687,0.00051388034,0.06355224,0.001082449,-0.11082873,0.022423755,-0.061388783,-0.012796208,0.0901266,0.036790874,-0.053793475,-0.035583556,0.026673427,0.049242567,-0.11424516,-0.09554657,-0.0073600975,0.0032133276,-0.050842267,-0.07984458,0.011206702,0.021353235,-0.029299391,-0.07062434,-0.050850183,0.02088714,-0.0467262,0.03889083,0.05690894,-0.056384955,-0.07655889,-0.04021885,-0.092372164,0.021079887,0.032462325,0.047070198,-0.0075712698,0.01470198,-0.08273715,1.6222685e-34,0.004726257,0.056328967,-0.033500206,-0.047825307,0.008907706,-0.07405326,0.025816793,0.04904715,-0.012785666,-0.046497498,-0.078444205,-0.058979627,-0.04668518,0.032336026,0.05061727,-0.021585895,-0.033618093,-0.050849408,0.070324615,-0.06822648,-0.054445695,0.009206834,-0.099769704,0.035896804,0.017321026,0.118212745,-0.043000016,-0.013930682,0.021023115,-0.026717411,0.02303876,-0.019409388,-0.04940752,-0.034206193,0.059882436,-0.013259804,-0.03441717,-0.032005705,-0.08189219,0.026908891,-0.014449848,0.02656351,0.08115708,-2.3824414e-05,-0.011646952,-0.026533678,-0.093460746,0.08920157,0.11451541,0.0146254115,0.028898869,-0.01703909,0.014333398,0.018089691,-0.03972831,0.047366984,-0.042680014,-0.0028695865,-0.030438388,0.017895734,-0.0112906555,-0.04051122,0.016942805,0.06849799,0.06006952,0.023844343,-0.06971183,0.0070513324,0.028515961,0.08663978,-0.038069803,-0.0075408234,-0.027836854,0.058815543,0.006140828,0.03940025,-0.0058963858,0.0046358514,0.03687209,-0.034884155,0.022270082,-0.06434639,-0.0009406358,-0.006699343,-0.040531237,0.003910879,0.05642009,0.01849676,-0.022857446,0.07715732,0.006462037,-0.008715452,-0.07103431,-0.019282214,-0.0066095777,-1.7209836e-33,0.08326291,-0.08475417,0.010136893,-0.027119644,-0.0136258155,0.100901306,-0.08769025,0.052336335,-0.008970663,0.11446213,-0.007863824,-0.012886605,0.1028917,0.00069465884,-0.04258558,-0.046514187,0.011515193,0.10459338,-0.009324919,0.018172123,-0.05392651,0.08738572,-0.046066333,0.043785557,0.00030180463,0.010681331,0.052007154,-0.0013374409,0.011982654,0.07522192,0.07221887,-0.0017057175,-0.05859377,-0.008320542,-0.021973975,0.11890567,0.047171343,0.020272372,0.0020189795,0.008046568,-0.006692451,-0.03198855,0.015154912,0.02956077,0.067190275,-0.025581492,-0.07694058,0.054369625,0.015715284,-0.020208234,0.07135931,0.03868461,0.0070611285,0.033302702,-0.012668629,-0.0081094755,-0.03886025,-0.12114843,-0.022332754,-0.12126188,0.023663081,-0.018340504,-0.06684859,-0.081397496,0.006363739,-0.009360852,-0.05225454,0.012776893,0.02171591,0.0068406323,0.08639829,-0.03105181,0.019060543,0.09391771,-0.052956644,-0.03198242,-0.038809992,-0.020200202,0.029917542,-0.04992081,0.004987449,-0.0014748819,0.047357004,-0.033021193,-0.008715547,0.0114285145,0.033781227,0.12849435,0.0032270795,0.012558322,0.028300732,0.004277574,-0.14534047,0.033197597,0.03194301,-2.6699603e-08,0.012748582,-0.05397527,0.06390381,0.026606357,-0.043811835,0.036794238,0.014110968,-0.05235072,-0.01787791,-0.033957902,0.01855876,0.06907739,-0.058507092,0.05828485,-0.0005269333,-0.018479003,0.016426872,0.08038681,-0.027364055,-0.0114356605,-0.09667612,0.010816759,-0.03349749,-0.07898288,0.058500715,-0.039037988,0.0457164,0.0852415,0.018976247,0.024455743,0.06730321,-0.0131563675,-0.026597446,-0.05661,-0.06985032,0.08418075,0.05452394,-0.084769696,0.04957216,-0.028002921,-0.003143361,-0.053124085,-0.0782344,0.021681378,-0.025437428,-0.016394977,0.049858484,-0.026616273,0.01661413,-0.0056026955,0.0015519647,-0.016877325,0.05060495,-0.05851918,-0.08268257,-0.01099076,-0.026287988,-0.005093874,-0.0001192952,-0.13303481,0.019208483,-0.018305859,0.2279804,0.029032633 +2.4.1.361,"The enzyme from the hyperthermophilic bacterium Thermotoga maritima is involved in the synthesis of the solutes 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate and 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate.",384,1.0,-0.018062323,0.0015544004,-0.101733625,0.009228139,-0.017644692,0.035244036,0.00019126417,0.0298236,0.01316606,0.08402277,0.058228213,-0.054032866,-0.042380832,-0.0002265746,-0.05072402,0.077527635,-0.037089273,0.03489043,0.064040124,0.025269926,0.08527823,0.046579685,-0.029406775,0.007357103,0.027582416,0.028391832,0.038788352,0.015552137,-0.072637685,-0.04781186,-0.029866513,-0.04524449,0.08163886,-0.06578905,0.12634502,0.10790517,-0.046122793,-0.07463551,0.08521396,-0.030566487,0.033603273,-0.024125645,0.00560806,0.06542084,-0.019204013,-0.00091797975,-0.042230573,0.050402127,0.083505265,-0.0180271,-0.086971715,-0.045321647,-0.0073841433,0.033453275,-0.025309345,0.018660227,0.0010070973,0.044304892,-0.049360044,0.0119191315,0.04889347,0.03959993,0.043241322,0.007092232,0.03851893,-0.08731147,0.016140612,-0.033969283,-0.0092647895,-0.025285212,-0.06698983,-0.025007874,0.023943098,0.04044148,0.01938135,-0.0014869861,0.0031690348,-0.016536849,0.042541437,0.02908787,0.039438836,-0.07497291,0.015872134,0.015944583,-0.027246118,-0.05341544,0.06729358,0.0035375103,0.1361508,-0.008548039,0.0018177452,-0.018679136,-0.049570914,-0.032599837,0.026747542,-0.0135357175,0.018881593,0.06229146,0.09077628,-0.053494442,-0.0029409018,-0.03371519,-0.08415474,-0.11701413,0.020940246,0.007844383,-0.034783047,0.013070335,0.030047862,-0.0030018615,0.025429817,-0.03625582,0.044315025,-0.0032887834,-0.046747167,0.0807089,0.044467535,-0.01798625,-0.048887547,0.009736348,-0.042637132,-0.027607245,0.006975963,0.044364933,-0.13129845,0.032553803,-0.08830305,-1.777888e-33,0.06914475,0.05989371,-0.011488651,0.035062615,0.030556982,-0.02935469,-0.017976765,-0.11133057,-0.111975625,-0.042372573,-0.088365205,-0.070975676,0.008120166,0.04254787,-0.038903996,0.06253943,0.007712904,0.0234321,0.038462434,0.034789763,-0.053606026,0.07691195,-0.018906903,-0.0053215623,0.019651737,0.14611241,-0.00087274186,-0.02415698,0.07229055,-0.022870228,0.06969879,-0.081980474,-0.15680407,0.037590962,0.07456465,-0.020938732,-0.06645967,-0.026457464,-0.037983526,0.044171434,-0.01927503,0.021317132,0.044827297,-0.0015110329,0.028193854,0.019439548,-0.056354623,0.06042844,0.017172387,0.06783593,-0.03434339,-0.03538694,0.029916618,0.01441064,-0.081861064,-0.04039796,-0.019046968,0.016901253,0.044015955,0.045096707,-0.059113927,0.0047973325,-0.0008340402,0.020954149,-0.028057441,-0.03809565,-0.024058457,0.018791035,0.023741685,0.079148754,-0.062350973,0.0017199122,-0.004143662,0.0023214503,0.015849844,-0.035449196,-0.038589396,-0.02743623,-0.06410659,0.0016681612,0.062093355,0.0046236445,0.05671349,-0.027567152,-0.053480346,-0.050682086,-0.0684014,0.0139693115,0.0023574466,0.049380526,0.037066247,-0.018976355,-0.07984705,0.07108044,-0.021073049,-7.5779997e-34,0.10689973,-0.11281913,0.08688207,-0.06970103,-0.086945444,0.052475557,0.004804834,-0.03237944,-0.010610978,0.044616748,0.08581556,-0.038964774,-0.01920375,-0.094368935,-0.0376125,0.021362413,0.077081576,0.06273421,-0.015877241,-0.0048613385,-0.009516459,0.10945959,0.0055289124,-0.014234815,-0.022254638,-0.0635089,0.0034461913,0.0194972,-0.0020227726,0.088904664,0.043644916,8.6436965e-05,-0.030010767,-0.09065603,-0.022002501,0.032801006,-0.03635499,-0.00901346,0.053763315,0.067440785,0.00856425,0.009334528,0.037102684,0.0013892149,0.011094846,0.034433525,-0.05861782,-0.018612118,-0.05472217,0.02513051,0.024689417,-0.12586659,0.03147153,-0.052235786,0.03639775,-0.036236495,-0.08108118,0.017598735,-0.03781145,-0.019710474,0.026813569,-0.106310494,0.04962124,-0.034504574,-0.04514358,0.16070424,-0.034515835,-0.04091163,0.0661333,0.008171237,0.019361388,-0.014326212,-0.020357525,0.078358956,0.026408156,-0.03387345,-0.08469306,0.02393787,0.07288282,-0.030577209,-0.029200783,0.045327626,0.0360181,-0.043817993,0.058012724,-0.023764681,0.057822473,0.08032361,-0.08230125,0.046799637,-0.012537016,0.04297482,-0.0246122,0.07262756,0.016436959,-4.4814836e-08,0.11594618,-0.07147627,0.06573052,-0.056570154,0.01014227,0.07415261,0.0069849454,0.041206937,0.08008258,0.04247203,-0.042707715,0.093253635,0.051537257,0.0026389707,0.008593618,-0.00033206466,-0.012632135,0.007924426,-0.0134932175,-0.022575011,-0.039522164,0.0018081367,-0.03590804,0.026444374,0.07840741,0.019447023,0.057925597,-0.01914428,-0.024450922,-0.026112612,-0.009761634,-0.0030604606,-0.09964339,-0.0668961,-0.10152008,0.0019672632,-0.06735197,-0.063926496,0.00888922,0.031791966,0.060231593,0.034405414,0.012564973,0.026216159,-0.00025512726,0.0036696745,-0.03648659,0.01137408,-0.047858924,0.02239357,0.05615903,-0.007884375,-0.065181755,-0.03721429,-0.14992839,-0.0054854867,0.0445785,0.005431689,-0.06983027,-0.030198839,0.017224165,-0.03532614,0.07709223,-0.05051532 +2.4.1.362,The enzyme from Leuconostoc spp. is responsible for producing alpha-(1->3) branches in alpha-(1->6) glucans by transferring the glucose residue from fructose to a 3-hydroxyl group of a glucan.,384,1.0,-0.027866315,-0.06572211,-0.1059996,-0.03497134,0.03784,0.008766758,-0.048925065,0.020973088,0.069749616,0.007988258,0.01101089,0.030587181,-0.055793565,-0.026518697,-0.08592912,-0.06624093,-0.1098251,0.020609818,-0.08133501,-0.0731994,0.09167295,-0.03915376,0.007828789,0.028073607,0.06872348,-0.028205642,0.020286206,-0.046010226,0.023251446,-0.083645225,-0.030366644,-0.08932238,0.060225125,-0.009303882,0.016439078,0.059331477,-0.04067264,-0.047683515,0.0093958005,0.02148312,0.024867045,-0.03896679,0.0043355883,0.0016991914,-0.049014412,-0.04172811,-0.08613464,0.02762407,-0.010173003,0.05977859,0.03423739,-0.077093616,-0.08725842,0.07537632,0.0071006427,0.03837601,-0.0118363425,-0.03522447,0.024477022,0.11346028,-0.0043755304,0.0230738,-0.086229526,-0.033925824,-0.012385407,-0.05147452,0.001664874,-0.056426283,-0.049397472,0.03131689,-0.010421279,-0.0054468308,-0.038233,0.028582186,0.064675026,0.005031516,-0.045935314,0.05978788,0.02163252,0.006247881,0.106307626,0.005627129,0.02154147,0.10644817,-0.038581684,-0.009298889,0.0011894263,0.0091792615,0.015191831,0.03648076,-0.011523,-0.035991583,-0.048687775,-0.050880495,-0.017388431,0.078482546,0.021111399,-0.0304255,0.08853564,-0.026967034,0.04367464,-0.022236943,0.09279251,-0.049524095,-0.14720671,0.04112125,-0.06070067,0.100125864,0.04330036,0.027113928,-0.011117945,0.010827009,-0.00044020527,0.028003018,-0.07683966,0.062193647,0.05629355,-0.08890621,-0.057841133,-0.014740945,7.1916664e-05,0.056236584,0.08682822,0.069189765,-0.048449546,0.03905929,-0.03213252,-9.006806e-34,0.09629905,-0.03209863,-0.04907504,-0.02825993,-0.07408201,0.046346407,-0.09848148,-0.020594683,-0.039479375,0.009736145,-0.079565026,-0.043349795,-0.004561128,0.011012657,-0.025927465,0.007614359,0.011934608,-0.051691916,-0.018586531,0.014214707,0.0207723,0.024680072,0.009086194,0.0003904331,0.03713613,0.033326685,-0.083893724,0.033467647,0.033914022,-0.00091481255,0.058301657,-0.024328506,-0.040725555,0.03410274,0.052579228,0.060805894,-0.03302041,-0.06042429,0.035542,0.066982746,0.061134312,0.0078118537,0.05867535,-0.030677572,0.07772047,0.0046182866,0.0028256963,0.07588681,-0.0009759849,0.080438145,0.036608264,0.02980015,0.029453604,0.021002734,-0.03564767,0.039175607,-0.03592004,-0.0057929587,-0.0148736555,0.04651094,0.04921021,0.112329595,-0.007829983,0.052792575,-0.034706183,0.020293647,-0.07813214,0.02472311,-0.026163543,0.06173752,-0.09051165,-0.054903127,-0.009862509,0.0107110115,0.021241115,-0.020619132,-0.0637959,0.08823096,-0.01103337,-0.03252512,0.010441251,-0.0074777436,-0.015303962,-0.0053834766,-0.11135707,0.013023212,-0.025685726,-0.07934719,-0.028169535,0.031117218,-0.010026758,-0.006536943,-0.04687319,0.10148888,0.0017323602,-2.2430195e-33,0.11660867,-0.16082281,0.12527676,-0.032387286,-0.03762275,0.06580935,-0.00637368,-0.09904532,-0.004103829,0.029226564,0.02677845,0.07541951,-0.028279591,-0.061007135,0.083026715,-0.059739918,-0.026113773,0.06405377,-0.00028791762,-0.012415462,-0.008216402,0.06902615,0.0046966085,0.017099375,0.032948922,-0.031983424,0.07227716,0.053556915,0.043432623,0.0011351686,-0.009705225,-0.037838902,0.035397377,-0.049680177,-0.01238729,-0.013249771,0.0049792887,0.007804582,0.014664587,0.0012544623,0.017994257,0.06284409,0.015295505,0.015010471,0.051646974,0.069504224,-0.024786662,0.033541884,-0.01769241,0.0068363436,0.010817801,-0.038019124,-0.033620242,0.034506407,-0.0033838945,0.048211668,0.014071454,0.007686956,-0.014730651,-0.062216632,-0.08494872,-0.021001,0.027152916,-0.09115735,0.086488456,-0.020167582,0.04507364,0.030605767,0.04344058,0.089319944,0.027306966,-0.036116935,-0.03813418,0.007914941,0.008621201,-0.038428515,-0.123001866,-0.07651827,-0.020181762,-0.084322356,-0.037540685,0.07267193,0.013729111,-0.03985501,0.09051683,-0.08808122,0.010975252,0.11558431,0.032133624,0.026363479,-0.01152606,0.030988343,-0.013258546,0.0007463567,0.08800229,-3.297755e-08,0.009913485,0.04040381,-0.07933205,0.028533522,-0.01672249,-0.0298229,0.00018465651,0.037166916,-0.008214438,0.0024542415,-0.07646913,0.1132302,-0.0051853186,-0.035850305,0.021746872,-0.016039442,0.012077868,0.011491633,-0.00015681596,-0.023492957,-0.10533368,-0.029497178,-0.045609504,0.044279557,-0.061001442,-0.13519123,0.019556226,0.09886699,-0.024930043,0.021910537,0.039510317,0.057968672,0.011623767,-0.09372144,-0.03605567,0.02257111,-0.045940198,-0.040413536,0.04845075,-0.025234431,0.03990241,0.0067734816,0.013181205,-0.029668245,-0.096081704,-0.02372416,-0.011498817,0.016319536,0.009253468,0.08499546,-0.009017458,-0.024751052,-0.038791157,-0.0020069329,-0.0059154276,-0.09823684,-0.012775693,-0.085593574,0.047259677,-0.04383314,0.018753685,-0.0017629002,0.15984203,-0.020714495 +2.5.1.152,"The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.",384,1.0,-0.043470457,0.0053226277,-0.11784927,0.02729313,0.0327196,0.030028898,0.0058451463,0.0036022877,-0.010111144,-0.040680833,-0.017198062,-0.13151287,-0.020513054,-0.02822146,-0.06678539,-0.031141423,-0.10070238,-0.0067524393,0.0079509625,-0.0038156533,0.042180326,0.02481011,-0.051573407,-0.04422001,-0.018021606,0.108338535,-0.007487231,-0.08123386,-0.026762946,-0.018071845,-0.070213266,-0.060027685,0.08504369,-0.037865814,0.057716887,0.06665356,-0.03594006,0.03824239,-0.034606576,-0.02454017,0.018611945,0.023892958,0.03943467,0.010827061,-0.02127258,0.020278223,0.12256986,0.04500198,-0.04798485,-0.0068140454,-0.009240265,-0.033596497,-0.03338756,0.04080705,0.038564175,0.03387654,-0.055009242,-0.08823942,-0.0215971,-0.05784976,0.08227392,-0.039108086,0.024396017,0.0047829216,0.07160352,-0.026085394,0.059134584,-0.09070942,0.012994599,-0.049580622,-0.018543711,-0.06552689,-0.038581807,0.016890991,0.006912511,0.09445505,0.115273856,-0.05771668,0.06150206,-0.0048980583,0.0031637691,0.08743643,-0.0009202383,0.05947371,0.0535134,0.0896171,0.013849011,0.0071820845,-0.038914528,0.030274047,0.020913983,-0.046886556,-0.05094526,-0.04714194,-0.08399309,0.042527422,0.0043763956,0.002939081,0.01987743,-0.011202694,0.038676273,0.07603678,-0.022041814,-0.056513637,-0.03324355,-0.065720126,-0.041545607,0.0835865,-0.010529304,0.037483785,0.03897806,0.025336297,-0.044171784,0.033826377,0.023828445,0.08242779,0.052212063,-0.06986494,-0.077269465,0.032270525,0.0050083897,-0.024353065,-0.027481083,0.059448224,-0.026009236,0.01136913,-0.09413323,-9.891257e-34,-0.03815348,-0.013110412,0.032339904,-0.070863634,0.07574447,-0.032353904,-0.06889549,0.002929367,0.024273936,-0.051348075,-0.053984553,-0.030478757,0.07936423,-0.008556748,-0.012743026,-0.016623128,-0.030490195,0.05840119,0.06775964,-0.034788683,0.009570925,0.09334492,-0.03724556,0.06069686,0.026937727,0.056759417,-0.047528695,-0.004664988,0.03894274,-0.02213749,0.03139012,-0.054079942,-0.03341885,-0.036493093,0.12824962,-0.038022943,0.022369765,-0.029150406,-0.0028190208,0.032111924,0.0052856617,0.028650688,-0.022599878,0.10505756,0.0403953,-0.08601613,-0.108982116,0.10980081,0.009157227,-0.003726126,0.023076987,-0.012694741,0.09235929,-0.030793162,-0.072753385,0.0811629,-0.04283839,0.004282037,0.034637865,0.030315312,-0.01261617,0.0761879,-0.009880629,0.0819534,0.039813887,0.02832797,0.012115473,-0.023494365,-0.001122493,0.08431709,-0.104252025,-0.02528023,0.015601683,0.035946857,-0.004538472,0.018490111,-0.040695738,-0.043473307,0.09455673,-0.014221074,-0.01668081,0.018332172,0.007841251,-0.09126652,-0.06788673,-0.07441106,-0.044334907,-0.06313413,-0.0043852613,-0.010183992,0.046341352,-0.0006041264,-0.1062993,-0.013887619,-0.040451914,-2.0252609e-33,0.051312596,-0.12702143,0.053722765,-0.089148425,-0.045593042,0.07547477,-0.057757493,-0.06689507,-0.0033084964,-0.010683991,0.07269146,-0.0010116785,0.03775986,0.01378302,0.004762868,-0.010544081,-0.014875924,0.13653618,0.027300857,0.006569646,-0.054782975,0.057846967,0.028402004,-0.05586259,-0.0069410964,0.0067179836,-0.064471856,0.0642694,0.06836231,0.011701697,0.016898958,0.019792369,-0.026215035,-0.0644207,-0.06898119,0.039011132,0.025981797,0.027056355,0.104214095,0.02175655,0.06357021,-0.01630339,-0.0056078644,0.08924151,0.041173056,0.056156024,-0.11411062,0.050740734,-0.030393604,-0.03303539,0.07744,0.041653473,-0.00317496,0.015874466,0.01838058,0.073827185,0.009597553,-0.030808954,-0.008097636,0.011655769,-0.06866696,-0.07145599,0.03186426,0.048928194,0.028989542,-0.018278472,-0.00064712384,0.04806285,0.025324916,-0.04057722,0.058623046,0.06949863,-0.0012880221,-0.041773837,-0.082307175,-0.06575539,-0.030834647,-0.017341312,0.048278097,-0.021692928,-0.036138885,0.05742984,0.09353384,0.008028832,-0.027227694,-0.069133975,0.08457263,0.1584121,0.0010413596,0.015698465,-0.05156579,-0.05069186,-0.0768395,0.038274597,-0.0029372901,-3.372215e-08,0.026955143,-0.013642516,0.06609357,-0.035351887,-0.02595947,0.07726956,-0.009902996,-0.051208396,0.031341985,-0.015600923,-0.022803878,0.024114164,-0.032745436,-0.08503647,0.012794185,0.047533166,-0.039435156,-0.04019275,0.0008781245,-0.010118248,-0.026315333,-0.0005783513,-0.03664327,0.037001193,0.016148893,-0.04697786,0.054097086,0.043211427,-0.11873276,-0.0026254288,-0.05021115,-0.004495473,-0.018329283,-0.0040087863,-0.07652054,-0.024956862,-0.012219974,-0.060150202,0.00054870953,-0.005680394,-0.016158063,-0.015321938,-0.07423842,0.023319606,-0.05347808,0.006644557,-0.03333145,0.06270265,0.010514558,-0.045125976,0.003236827,-0.007329109,-0.02008294,-0.061600804,-0.07607299,0.048805855,-0.0043871226,-0.078324124,-0.06357661,0.056939736,0.02835951,0.030974416,0.15594812,-0.0037197354 +2.6.1.115,"The enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), participates in the biosynthesis of coelimycin P1, where it catalyses the amination of (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal. L-glutamate can also serve as the amino group donor with lower efficiency.",384,1.0,-0.071551524,-0.061269004,-0.12751159,-0.04908376,0.024095958,0.02720687,-0.057545297,0.056236472,0.09007471,0.0005333848,0.04715286,-0.07614992,0.01857257,0.053686038,-0.016018072,-0.056444727,-0.05822996,-0.033062056,0.020764073,-0.10111259,0.11881895,0.102468796,0.004322242,-0.03085295,0.06975282,0.020105552,0.024186032,-0.0040456057,0.022544628,-0.046953287,0.037289035,-0.06229368,0.029571338,-0.02862391,0.069443285,0.07856911,-0.059004232,-0.07341436,0.097768255,0.0090758,-0.008050111,0.021450529,0.01910618,-0.020661704,-0.07193618,-0.014333884,0.05253568,0.03656636,0.03016901,-0.054193314,0.019255998,-0.05250046,-0.07760471,0.05033599,0.05942869,0.056406498,-0.008309882,0.0014113417,-0.020330599,-0.023981905,0.033380065,0.007167111,0.018458193,0.017945949,-0.00871044,-0.052908007,0.022458132,-0.082288325,0.04149074,-0.05740271,-0.1101997,-0.06738337,0.042400774,0.031730488,-0.0061764345,-0.0069804033,-0.050420973,-0.030827634,-0.03045325,-0.0071682706,0.061698686,-0.05270877,0.011188255,0.09737146,0.044804666,-0.057900373,0.00027404886,0.017466486,0.0821067,0.059461594,0.043117993,0.002433612,-0.024252167,-0.03164386,-0.13249038,0.02460161,-0.0604162,-0.02921243,0.043967936,-0.013311789,-0.014347623,0.097665325,0.048099987,-0.007524209,-0.043677405,0.01521688,-0.03125991,0.075595,0.050937336,-0.035078146,0.0023960785,0.017661294,0.038424153,-0.04103659,-0.027658625,0.07834546,0.08108536,-0.072161846,-0.023704143,-0.0017204091,0.00074831705,0.000681699,0.030958597,0.041711602,-0.011007567,0.030249862,-0.13708247,1.9256317e-33,0.018636176,0.018151049,-0.004993373,0.0030214028,0.021331815,-0.005948221,-0.07456122,0.0024170587,-0.01785822,-0.041033085,-0.10751244,-0.11366013,0.020179624,0.06545552,0.048202652,-0.028101865,-0.038298253,0.028846981,0.018821487,-0.0020565214,-0.022611748,0.019259049,-0.0011108678,0.023003383,0.07334243,0.047023807,-0.00038355595,0.040640686,0.0853277,-0.033683937,-0.032620084,-0.037661493,-0.10260658,-0.0033651171,0.05082434,-0.021721108,-0.039834164,-0.041212507,0.061881226,0.094192155,0.014881694,0.0144639965,0.012715579,0.018474858,0.07105428,-0.04144461,-0.021338424,0.07455766,0.0017630932,0.089665376,0.07722956,-0.06553207,0.04434247,0.01290194,-0.097161405,0.040038645,-0.0138857635,0.017271133,0.03939147,0.025771003,0.0033900433,0.008657714,-0.018352548,0.025278274,0.0079661375,0.053008992,-0.016851705,-0.06377775,0.021286828,0.08240522,-0.11250228,-0.024195082,0.037097223,0.03954604,0.0554822,-0.024969717,-0.024740878,-0.012401234,0.08027813,-0.0016312771,-0.04380208,0.019474018,0.019251155,-0.003774577,-0.063486956,0.01624521,0.010154161,-0.12999938,0.04130241,0.031388454,0.025927104,-0.08658592,-0.04649273,0.007380618,0.04152424,-3.1463076e-33,0.10716483,-0.106467925,0.0430069,-0.09176125,-0.054561634,0.037215497,-0.05399978,-0.056249555,0.0008079114,-0.047793634,0.08624249,0.020588586,0.032678425,-0.06132297,0.038243633,-0.061695043,0.016096551,0.098890625,-0.007178303,0.00996743,0.09198414,0.05959985,0.037686884,-0.062199634,0.037551466,-0.005985452,-0.008410531,0.038691007,0.08729204,0.02764585,-0.029042369,-0.046462126,-0.039015908,-0.021653442,-0.027615637,0.08596595,-0.059981998,0.010177415,0.03012002,0.025985308,0.07902267,0.07975006,0.04220057,0.052203007,-0.025613207,0.00049072976,-0.024301581,-0.044002827,0.029853297,-0.075850084,0.021012796,-0.01304385,-0.004558488,-0.013002918,0.016683029,-0.025444943,0.046323907,-0.07207371,-0.021110032,-0.04608856,-0.0750012,-0.051150903,0.03895349,0.022012407,0.0623226,-0.0009561453,0.0076485854,0.036623552,0.09546548,0.0096257925,0.098849766,-0.031339455,0.024512017,0.04040194,0.0009063547,-0.064035684,-0.11752635,0.022439059,0.01807611,-0.03393975,-0.011185157,-0.008103072,0.012807819,-0.07289646,0.0016901112,-0.094595395,0.009390325,0.08860927,0.053511426,0.037651118,-0.027936377,0.027806072,0.031706378,0.03929784,0.047158726,-4.2428308e-08,0.015903674,-0.019452881,0.010646428,-0.00011631136,0.07797684,0.038628094,-0.05243933,-0.056411937,0.028030768,-0.0051524825,0.0057493923,0.013085441,0.00864183,-0.006152236,-0.036374483,0.09450309,-0.09417009,-0.015693404,-0.0077183135,-0.028925082,-0.15041535,-0.0020145308,-0.11783729,0.014808937,0.0660277,-0.022721317,-0.04261294,0.06488617,-0.022944575,-0.002827037,-0.0066898777,0.018637415,-0.03386942,-0.03157601,-0.05395452,-0.017047232,-0.016479842,-0.025018536,-0.021396188,0.007435182,0.0408068,-0.016792538,-0.058272306,0.0326066,-0.020801244,0.059450824,0.002421046,0.0016656893,-0.10749238,-0.020044923,0.09165456,-0.02259792,-0.017808946,0.011542672,-0.15258124,-0.029098876,-0.03839562,-0.028906152,-0.039671358,-0.053585477,-0.020747768,0.03142312,0.14304996,-0.022683252 +2.7.1.225,"The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of L-2,3-diaminopropanoate, which is used by that organism as a precursor for the biosynthesis of the siderophore staphyloferrin B.",384,1.0,-0.062365875,-0.050556436,-0.14128876,-0.036174636,0.045264754,0.041507065,-0.10179954,0.039945856,0.030728728,-0.016195744,0.03464321,-0.075145416,-0.09837473,0.015223307,-0.03703213,0.07734507,-0.11931961,0.010453348,0.0053036786,-0.010012969,0.04077005,0.07168741,-0.018010208,0.0007142524,0.06439724,0.02114008,0.019306595,0.007753809,0.021320695,-0.02922435,-0.009553119,-0.050252017,0.020563448,-0.0681671,0.03701846,0.064414434,-0.0442264,-0.07168498,0.037918236,0.031016907,0.0070452406,-0.03072289,-0.010845895,-0.03500198,-0.03504036,0.011691184,0.020510532,0.066622965,0.01196607,-0.014314398,0.015189464,0.0112851225,-0.06660785,-0.0078064906,-0.05811824,0.0070973365,-0.053921413,0.020127619,-0.008681205,0.026695171,0.037604917,0.045184836,0.0063282135,-0.0053246194,0.017259464,-0.08345601,0.014642846,-0.122778654,0.048558205,0.029983902,-0.061159093,-0.07764312,0.015356035,0.024245728,0.01756519,0.055433825,0.026372408,0.024289088,0.0026579692,-0.06677296,0.10968187,0.022148719,-0.02015628,0.14552395,0.008032102,0.028186582,-0.020488834,0.01903424,0.018133905,0.027912444,0.05167364,-0.057060227,-0.017416855,-0.08508296,-0.05305913,0.033927485,-0.038383216,0.010313903,0.02681017,-0.0019369725,-0.052647155,0.04036222,-0.0035113208,-0.08601321,0.020044118,-0.047693584,-0.032336336,0.060195364,0.053596556,-0.04612307,0.081250735,0.06883806,-0.036867075,0.008463665,0.0108427005,0.076240145,0.081600666,-0.12640171,-0.047538288,-0.008522251,0.013443165,-0.07624328,-0.0038517532,0.039406966,-0.07079734,-0.014042865,-0.107702255,1.132206e-33,0.043814987,0.023300795,0.01935622,-0.046858735,0.0039487486,-0.02909972,-0.09934884,-0.011995412,0.005490253,-0.04633703,-0.05404143,-0.069845825,0.05981814,0.023324473,0.01705997,-0.045850404,0.013599646,0.038962062,0.04925935,-0.04022177,0.02355432,0.06561874,-0.027588828,0.028603625,0.011811745,0.07472712,0.032480463,0.020810967,0.10602315,-0.01657531,0.036477637,-0.093162306,-0.038896818,-0.027986288,0.11118549,0.008813569,-0.041478414,-0.053688485,0.045542143,0.036134735,0.009063895,0.043588877,0.013781184,0.033425555,0.03579965,-0.05320661,-0.012868439,0.08735424,0.049495727,-0.0121697895,0.049435943,-0.030607404,0.096870236,-0.02432523,0.002685957,0.035084665,-0.022482892,0.0055026347,0.0395276,0.068609565,0.016493673,0.014530804,-0.029590856,0.0704547,0.001871138,0.021120993,0.05935349,-0.04217284,-0.00935855,-0.0017894942,-0.06113351,-0.076710686,0.035379954,0.009719194,0.023125207,0.004834098,-0.017459262,0.005195954,0.04702678,-0.06519574,-0.0054537775,0.004757847,-0.0019335585,-0.057566565,-0.08751835,-0.025418311,-0.041185208,-0.07011941,-0.011975736,0.029544197,-0.0020764556,-0.06813151,-0.04240279,0.042329744,-0.043832604,-3.8417977e-33,-0.0057056798,-0.15767998,0.04075816,-0.106754616,-0.052204452,0.08743342,0.01878229,-0.0368059,-0.057167348,0.023695514,0.081428014,0.0010666628,0.008140448,-0.018635413,0.016045025,0.0077331825,-0.0040253727,0.053194556,-0.0007291783,0.018237647,0.026612015,0.07892207,0.073079064,0.019268485,0.035385083,0.024932548,-0.020511003,0.046045046,0.03739129,0.013740674,-0.055042543,-0.05527168,-0.02162168,-0.049270708,-0.04206602,0.03744717,-0.003841958,0.01388204,0.061085276,-0.030757213,0.045191687,0.0060664085,0.0019627332,0.06935398,0.03399413,0.029857848,-0.13205032,0.05669181,-0.0076203207,-0.08960032,-0.029681066,0.047444053,0.023695001,0.022257214,-0.02648035,0.052459233,0.021199211,-0.038218673,0.007690274,0.027486479,-0.058219284,-0.118353374,0.009859466,0.047025487,0.058291674,0.05524485,0.00291608,0.020224769,0.010947996,-0.066707276,0.08966227,0.014716347,0.01272816,0.062323883,-0.08518552,-0.06847381,-0.042464003,-0.10943313,0.012949972,-0.02115026,-0.038966298,-0.012705566,0.027468305,-0.011189961,-0.05142177,-0.10668285,0.06930745,0.14444387,-0.02505754,0.0054654772,0.045593906,0.0119084045,-0.05780269,0.08992174,0.08132445,-3.8306425e-08,0.046389285,-0.03378682,0.14475839,-0.0524804,-0.02587224,0.014863908,-0.029261256,0.00020408556,0.01961783,-0.017467542,-0.07781822,0.02188316,-0.042201284,-0.053559132,0.022350315,0.04679086,-0.02947403,0.019968636,-0.019793358,-0.031417895,-0.021986844,-0.013309033,-0.06495436,-0.03664142,0.051016957,-0.04386557,-0.021723302,0.08786467,-0.034769062,0.005669334,0.0023573586,0.0053458554,-0.0082871225,-0.006497637,-0.09583777,0.014623067,-0.06592186,-0.11497717,-0.04394626,0.020719223,0.004753748,0.05988779,-0.053682454,0.040244546,-0.03488237,0.038688615,0.040178157,0.022062732,-0.014781893,0.02743282,0.037371382,-0.062971525,0.0040221247,-0.057480283,-0.13889489,0.0010196448,-0.034919135,-0.07176691,-0.018596774,0.025300058,0.013830691,0.098486185,0.17056037,0.03696802 +2.7.1.226,"The enzyme, characterized in the hyperthermophilic archaeon Thermococcus kodakarensis, participates in L-cysteine biosynthesis.",384,1.0,-0.065833,-0.045585714,-0.07487312,0.010979485,0.06832048,0.10116351,-0.0964844,0.029741097,0.016993303,-0.008420437,0.034727726,-0.081430376,-0.0137430355,0.04055222,-0.08724247,0.030319855,-0.0695433,0.025399435,0.03810555,0.014301713,0.098633476,0.025230147,-0.05094611,0.07276671,0.033619314,-0.029937973,0.009002571,0.03310805,-0.077294484,0.08728891,-0.119713,-0.07916261,0.045370962,-0.0003777165,0.10436556,0.09605817,-0.06612444,-0.039779574,0.08135509,0.04126412,0.05780375,-0.044734012,0.027610736,-0.00037910926,-0.022522334,0.049960464,0.0016726136,-0.00242927,-0.0041542053,0.02361294,-0.045144554,-0.019688224,0.0004006778,-0.002768885,-0.013414251,0.087879576,-0.07094432,-0.027157273,-0.0037743058,-0.03687845,0.073054455,0.0023311775,-0.050701324,0.06446422,0.03578595,-0.0789481,0.035140242,0.012691075,-0.0081435,-0.080452,-0.052646495,-0.01146447,-0.042492423,0.075923726,0.02364735,0.08680652,-0.036387075,-0.056877322,-0.006304554,-0.03743991,0.1437853,-0.0014059743,-0.056625057,0.04694063,0.015908862,-0.051645134,0.11064972,0.026796278,0.06515508,0.009309834,0.035025384,-0.004165745,-0.06876172,-0.058390383,-0.08144993,-0.036462404,0.06597053,0.06812498,0.021830281,-0.06994453,-0.010999994,0.0134520335,-0.003296282,-0.06553,0.021785216,-0.050652765,-0.01995921,0.05005448,0.0449996,-0.013660257,0.028039379,-0.03009557,0.025577346,-0.028005496,0.01926244,0.06628187,0.02046538,-0.03121544,-0.14020255,0.05713648,-0.011357479,-0.025802637,0.04173496,0.042948622,-0.1134989,0.03986531,-0.107426465,3.0183983e-34,0.052528642,0.033357218,-0.005502936,-0.030109147,0.09270879,-0.008351142,-0.03523368,-0.023043301,-0.053279877,-0.08221684,-0.056076113,-0.010326883,0.054418728,-0.0026894442,-0.06775529,0.0673417,-0.009830493,-0.020438978,0.048561163,0.016438222,-0.029823475,0.091650166,-0.0006770285,0.042803343,0.0055729635,0.029481035,0.010866902,-0.02169365,-0.0172319,0.015251064,-0.04141104,-0.13371666,-0.10434776,-0.03550207,0.09841495,-0.036131885,-0.0023247213,-0.07890091,-0.0023339612,-0.027316986,-0.026537754,-0.010165569,0.04501292,-0.0034944413,-0.01066596,0.0063086497,-0.03138033,0.080730036,-0.072579145,0.042627677,0.045871273,-0.03854466,0.03789191,0.0019448787,-0.08149859,-0.006325763,-0.050877027,0.02994303,-0.008156211,0.042217746,-0.025854256,0.08756203,-0.019608973,0.06826193,-0.049280465,-0.04482676,-0.07641623,-0.028518226,-0.0145378895,0.091086954,-0.038490158,-0.04872617,0.041611757,0.006237473,0.017027691,0.00825176,-0.05697419,-0.023936149,-0.00010748437,-0.04090287,-0.072784625,0.016467985,0.048011288,0.041091975,-0.037517782,-0.072435886,0.0024824324,0.02225886,-0.028342513,0.03876438,0.04148095,-0.079272754,0.009359853,0.07133777,-0.07432094,-2.2158206e-33,0.092132695,-0.107877076,0.04520827,-0.078715295,-0.042992778,0.076155104,0.008960023,-0.026873708,-0.018716177,-0.06272842,0.111523606,-0.0115337325,-0.023024254,-0.012824033,0.083873175,0.016249087,0.020866744,0.07813963,-0.002851096,0.037121665,0.035100475,-0.0077600745,-0.019833505,0.00095555105,0.042762287,-0.001781562,0.013451474,0.08324738,0.029369714,0.060849275,-0.034593433,0.016695267,-0.039316878,-0.08162463,-0.022551715,0.11394623,0.062065925,-0.022431688,0.098143645,0.054471515,-0.010487696,-0.010325382,-0.04113977,0.058341898,0.066900164,0.02289043,-0.010625318,-0.02147595,0.0003234058,0.017711222,0.050160598,-0.06403242,0.007221876,0.01169951,-0.055839434,0.018426986,-0.05022464,0.0449626,-0.019326508,-0.027455635,0.001014059,-0.074721836,-0.006588235,0.042231295,-0.024383513,0.07059469,-0.029249031,-0.0051882574,-0.011555157,-0.023849413,0.08545897,0.016931454,0.012253144,0.03593309,0.009582999,-0.062121447,-0.0303601,0.02087067,0.034643058,0.029402126,-0.035725195,0.048028857,0.09118446,-0.018324245,0.005326512,-0.051422425,0.08973111,0.03512133,-0.037057012,-0.0401287,0.043535907,-0.011028236,-0.03809492,0.057065193,0.030263774,-2.5091571e-08,0.08966625,-0.05879302,0.070617676,-0.10301538,0.011424853,0.018451793,0.03990574,0.033903524,0.047406267,-0.040185906,0.04454732,0.043123223,0.0164694,0.04465584,0.047078166,-0.006146898,-0.075064704,0.036170285,-0.050891846,0.043393534,-0.042740557,-0.050379064,-0.07412063,9.21793e-05,-0.008937572,-0.068234175,0.034674454,-0.015762344,-0.03568098,-0.019548213,-0.0058841975,-0.029171692,-0.075888954,-0.009278464,-0.09708232,0.035531517,-0.06370715,-0.06224614,-0.029931754,0.013363927,-0.0065672123,0.0034151275,-0.051716696,0.054411963,0.047971237,-0.053812284,-0.019639775,0.055939913,0.04488212,0.03711572,0.02324457,-0.014482945,-0.011917129,-0.06566533,-0.07959051,-0.076752424,0.05682433,-0.0027233232,-0.06990373,-0.029482357,-0.004904522,0.03536952,0.16495365,-0.026498303 +3.1.1.105,"The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.",384,1.0,0.028386822,-0.004425603,-0.09635473,0.010593557,0.030045101,0.08346836,-0.06808854,0.046061445,0.06817627,-0.08793833,0.028173015,-0.0012374392,-0.032407466,-0.040776346,-0.037456553,0.019344028,-0.07340375,0.0370573,0.02566771,-0.038339194,0.036440287,0.028704995,0.051243514,0.03258431,0.010143648,0.0733145,-0.04858425,-0.0089348415,0.046625074,-0.07468144,0.07493793,0.015830098,0.013280946,-0.038497522,-0.063648075,0.038134206,-0.06742112,-0.010247411,0.109221,0.043081265,0.07952477,-0.05843749,-0.07462485,0.022907322,-0.018048152,0.021387368,0.00073519174,0.034866985,0.028425125,-0.021020764,-0.025455805,-0.06690524,-0.067027174,0.06527406,-0.015667245,-0.012325103,0.03512686,0.021209467,-0.02745011,0.058752164,-0.011076733,0.062097583,0.02525266,0.040374298,0.059168432,-0.020245222,-0.0032238518,0.007264759,0.07988552,-0.03891499,-0.01097218,-0.08233014,0.008026108,0.016845888,-0.07109184,0.07332511,-0.084499486,0.029930936,-0.018088702,0.0046356902,0.106852666,0.034007333,-0.01568728,0.09747714,-0.014708801,-0.018296888,-0.03860012,0.035807576,0.05528687,0.00051388034,0.06355224,0.001082449,-0.11082873,0.022423755,-0.061388783,-0.012796208,0.0901266,0.036790874,-0.053793475,-0.035583556,0.026673427,0.049242567,-0.11424516,-0.09554657,-0.0073600975,0.0032133276,-0.050842267,-0.07984458,0.011206702,0.021353235,-0.029299391,-0.07062434,-0.050850183,0.02088714,-0.0467262,0.03889083,0.05690894,-0.056384955,-0.07655889,-0.04021885,-0.092372164,0.021079887,0.032462325,0.047070198,-0.0075712698,0.01470198,-0.08273715,1.6222685e-34,0.004726257,0.056328967,-0.033500206,-0.047825307,0.008907706,-0.07405326,0.025816793,0.04904715,-0.012785666,-0.046497498,-0.078444205,-0.058979627,-0.04668518,0.032336026,0.05061727,-0.021585895,-0.033618093,-0.050849408,0.070324615,-0.06822648,-0.054445695,0.009206834,-0.099769704,0.035896804,0.017321026,0.118212745,-0.043000016,-0.013930682,0.021023115,-0.026717411,0.02303876,-0.019409388,-0.04940752,-0.034206193,0.059882436,-0.013259804,-0.03441717,-0.032005705,-0.08189219,0.026908891,-0.014449848,0.02656351,0.08115708,-2.3824414e-05,-0.011646952,-0.026533678,-0.093460746,0.08920157,0.11451541,0.0146254115,0.028898869,-0.01703909,0.014333398,0.018089691,-0.03972831,0.047366984,-0.042680014,-0.0028695865,-0.030438388,0.017895734,-0.0112906555,-0.04051122,0.016942805,0.06849799,0.06006952,0.023844343,-0.06971183,0.0070513324,0.028515961,0.08663978,-0.038069803,-0.0075408234,-0.027836854,0.058815543,0.006140828,0.03940025,-0.0058963858,0.0046358514,0.03687209,-0.034884155,0.022270082,-0.06434639,-0.0009406358,-0.006699343,-0.040531237,0.003910879,0.05642009,0.01849676,-0.022857446,0.07715732,0.006462037,-0.008715452,-0.07103431,-0.019282214,-0.0066095777,-1.7209836e-33,0.08326291,-0.08475417,0.010136893,-0.027119644,-0.0136258155,0.100901306,-0.08769025,0.052336335,-0.008970663,0.11446213,-0.007863824,-0.012886605,0.1028917,0.00069465884,-0.04258558,-0.046514187,0.011515193,0.10459338,-0.009324919,0.018172123,-0.05392651,0.08738572,-0.046066333,0.043785557,0.00030180463,0.010681331,0.052007154,-0.0013374409,0.011982654,0.07522192,0.07221887,-0.0017057175,-0.05859377,-0.008320542,-0.021973975,0.11890567,0.047171343,0.020272372,0.0020189795,0.008046568,-0.006692451,-0.03198855,0.015154912,0.02956077,0.067190275,-0.025581492,-0.07694058,0.054369625,0.015715284,-0.020208234,0.07135931,0.03868461,0.0070611285,0.033302702,-0.012668629,-0.0081094755,-0.03886025,-0.12114843,-0.022332754,-0.12126188,0.023663081,-0.018340504,-0.06684859,-0.081397496,0.006363739,-0.009360852,-0.05225454,0.012776893,0.02171591,0.0068406323,0.08639829,-0.03105181,0.019060543,0.09391771,-0.052956644,-0.03198242,-0.038809992,-0.020200202,0.029917542,-0.04992081,0.004987449,-0.0014748819,0.047357004,-0.033021193,-0.008715547,0.0114285145,0.033781227,0.12849435,0.0032270795,0.012558322,0.028300732,0.004277574,-0.14534047,0.033197597,0.03194301,-2.6699603e-08,0.012748582,-0.05397527,0.06390381,0.026606357,-0.043811835,0.036794238,0.014110968,-0.05235072,-0.01787791,-0.033957902,0.01855876,0.06907739,-0.058507092,0.05828485,-0.0005269333,-0.018479003,0.016426872,0.08038681,-0.027364055,-0.0114356605,-0.09667612,0.010816759,-0.03349749,-0.07898288,0.058500715,-0.039037988,0.0457164,0.0852415,0.018976247,0.024455743,0.06730321,-0.0131563675,-0.026597446,-0.05661,-0.06985032,0.08418075,0.05452394,-0.084769696,0.04957216,-0.028002921,-0.003143361,-0.053124085,-0.0782344,0.021681378,-0.025437428,-0.016394977,0.049858484,-0.026616273,0.01661413,-0.0056026955,0.0015519647,-0.016877325,0.05060495,-0.05851918,-0.08268257,-0.01099076,-0.026287988,-0.005093874,-0.0001192952,-0.13303481,0.019208483,-0.018305859,0.2279804,0.029032633 +3.1.4.59,"The enzyme, described from Gram-positive bacteria, degrades the second messenger cyclic di-3',5'-adenylate. It is a membrane-bound protein that contains a cytoplasmic facing Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1 domain, which confers the phosphodiesterase activity. Activity requires Mn2+ and is inhibited by pApA.",384,0.99999994,-0.08891264,-0.06629959,-0.0005300537,-0.059677638,0.013881371,-0.03031696,-0.00019298997,0.052875526,0.074034385,0.04559939,0.06232281,0.022099914,0.0004881579,0.08147265,0.03714174,0.048342574,-0.08106752,0.00018438073,0.044077087,-0.05939985,0.09553963,0.050938457,-0.06524408,-0.052720807,0.024112236,0.033985108,0.055589247,0.004192337,0.028847335,-0.06579335,-0.061237592,0.0014364145,0.05414682,0.0012020094,0.047518186,0.14372627,-0.04435684,-0.057069443,0.018652236,-0.04437978,0.09150774,0.04728726,0.015857797,-0.07115912,-0.044705994,0.058571942,0.021069303,0.068312235,0.057865698,-0.016590608,0.01705634,-0.068313405,0.00074823125,0.00487873,0.018822396,0.025703616,-0.09719087,0.001609678,-0.009598634,0.014660527,0.01284934,-0.013407238,0.01901801,0.01150518,0.032587454,-0.11378263,0.019355228,-0.04354976,-0.016580185,0.021561965,-0.05174756,-0.059761483,0.020686233,0.0054451567,0.019938035,0.054775234,-0.06717685,-0.08862153,0.016054442,-0.09619994,0.089656316,0.009529495,0.11409372,0.092455976,0.005372474,-0.007941954,0.022413915,-0.04077701,-0.011744392,-2.953655e-05,0.021562155,-0.032290503,-0.032904167,0.019563824,-0.06740459,-0.0035506065,0.0098831095,-0.004190757,-0.038482558,0.060000632,0.02848082,0.09153158,-0.034715153,-0.08441697,0.0061695,-0.008703168,-0.019899078,0.049990095,-0.00670818,0.020437574,0.0063552638,0.08763974,0.01614262,-0.058027644,-0.0045286347,0.04958909,0.026347307,-0.047182377,0.010003067,-0.048899643,-0.050616153,-0.033385567,-0.017863153,0.053777598,-0.043725327,0.07417494,-0.073300324,-1.2443962e-33,0.011882665,0.028454619,0.05178861,-0.026673578,-0.008291404,0.019440388,-0.038776617,-0.04459871,0.0038010795,-0.058509376,-0.02638757,-0.08622787,0.044020455,0.019621138,0.0075501176,0.00013948578,-0.054899752,0.013044122,0.08064295,-0.024034763,-0.042091,-0.0075495187,-0.06698661,-0.015997972,0.073122114,0.08008003,0.0062093423,-0.044273403,0.033317946,-0.005948051,-0.030943787,-0.045786668,-0.1193816,0.034887545,0.043555804,-0.007630107,-0.03151707,-0.052408513,-0.032499135,0.011420542,-0.03206451,-0.01532243,-0.024406075,-0.038835526,0.023584008,-0.0825479,-0.02700113,0.05007605,-0.04615516,0.048195064,0.062963374,-0.02838098,0.05310464,-0.07694519,-0.09170288,-0.0044620386,0.0113606285,-0.052024562,-0.01385014,0.04625879,0.08528128,0.021049375,-0.068940334,0.032326907,0.0063554826,0.013214132,-0.10454962,-0.17675436,0.034083195,0.13930237,-0.046873283,-0.08294636,0.05919207,0.03449451,-0.006586145,-0.0006463412,-0.0049620187,0.08053591,0.055359866,0.05806038,-0.018429698,-0.053438798,0.049047887,-0.024845531,-0.049450185,-0.06155098,0.05598206,-0.11305193,-0.021131177,0.024333518,0.096241236,-0.0121516045,-0.04339541,0.10504618,-0.0314716,-9.343623e-34,0.041515402,-0.018165603,0.048107874,-0.06917565,-0.10684645,0.041163012,0.003763605,0.009820911,-0.0062822495,-0.026966957,0.061590392,0.0053020273,0.02378545,-0.019750683,0.102484636,0.0043025874,0.024116974,0.026206404,-0.051885467,0.026680354,-0.007829789,0.1065943,0.04527837,0.10547169,0.037087247,-0.014519692,0.0085612945,0.050743934,0.020114806,0.015415263,-0.026524054,0.014334473,-0.042890623,-0.019287903,-0.0066388617,-0.028505089,-0.048929293,-0.017978968,-0.012040548,0.02163406,0.022365376,0.058353093,0.02672349,0.08403571,-0.005278072,0.073156886,0.007608334,0.08231813,-0.017017951,-0.08289928,-0.006181336,-0.052972518,0.04899058,0.0076508555,0.002761754,-0.003873846,0.021893105,0.031263456,-0.0013856327,-0.024528347,-0.035814643,-0.0813137,0.00015258818,0.020206494,0.026310878,0.038907465,0.0075043514,0.013282746,0.0071965368,0.021221314,0.028940137,0.08080465,-0.025235781,-0.029980602,-0.04810001,0.017477386,-0.037503473,-0.016861424,0.008115931,-0.06288952,-0.013193367,0.0087476615,-0.042067304,-0.061890256,0.042248122,-0.017083835,0.030030845,0.13009734,-0.029394552,0.0651296,-0.0029555531,-0.036189932,-0.09373619,0.046058994,0.0023503853,-4.5845052e-08,-0.0008855264,-0.1044034,-0.00040741378,-0.14312202,-0.01930557,0.014477531,-0.00024296113,0.007940575,0.09746082,0.016377095,-0.014482218,0.074305154,-0.043423012,-0.010064392,0.009289387,0.04686265,-0.048086952,0.045973692,-0.01867693,-0.024859259,-0.082567096,0.0014774112,-0.10570552,0.039624985,0.040710546,0.0200443,0.11320942,0.020027837,-0.0011237981,0.013997275,0.048924994,0.051900156,-0.041415386,-0.03327434,-0.07878563,0.01709158,0.025121028,-0.049531333,-0.07071182,0.041352525,0.006056721,0.03555846,-0.055123497,-0.009254609,-0.013378391,0.03054145,0.05479809,0.00077203696,-0.017015172,-0.058810804,-0.0025033501,-0.017182346,-0.014538756,-0.057272434,-0.15259534,-0.0538446,-0.04689839,-0.097373195,-0.029536635,-0.038232382,0.03167607,0.030052211,0.18468492,-0.009364397 +3.1.4.60,"The enzyme, characterized from the Gram-positive bacterium Staphylococcus aureus, is a cytoplasmic protein that contains a DHH/DHHA1 domain. It can act on cyclic di-3',5'-adenylate with a much lower activity (cf. EC 3.1.4.59, cyclic-di-AMP phosphodiesterase). Activity requires Mn2+ and is inhibited by ppGpp.",384,1.0,-0.061976936,-0.038828295,-0.046847608,-0.03658221,0.002838962,-0.0016497005,-0.056951392,0.04333354,0.019946652,0.015923535,0.03182715,-0.022137152,-0.0075196675,0.11897367,0.006603067,0.044288665,-0.057940185,-0.03942412,0.08041976,-0.034348488,0.08808229,0.09434818,-0.05392811,-0.052257825,0.04912565,0.057362147,0.025913166,-0.0016683697,0.0005218698,-0.033401724,-0.057005305,-0.04813063,0.08782026,0.019090356,0.025527386,0.115867175,-0.04506638,-0.013478572,0.020898174,-0.039944228,0.06912225,0.03781541,0.065009825,-0.04807865,-0.042099312,0.03559838,0.05546373,0.042864524,0.03828786,-0.015539501,0.044931583,-0.04482102,-0.01566389,0.06386559,0.005462189,-0.021976763,-0.059357762,0.022085156,-0.05363996,-0.03540679,0.017037285,-0.008548217,0.035508014,0.015161547,0.054741934,-0.098607354,0.018408854,-0.059455477,-0.019943409,0.010643099,-0.03911717,-0.037125796,0.03617664,0.019701486,-0.014049196,0.026507128,-0.028119685,-0.07055966,0.034221336,-0.035254125,0.05916255,0.02585569,0.07481,0.13817494,0.028967569,0.046742793,-0.002002557,-0.017470505,-0.01954064,-0.021876477,0.019568728,-0.02561664,-0.05053041,-0.018367046,-0.050681647,0.0030464218,-0.046038456,-0.035639323,-0.017237544,0.04177672,-0.00933171,0.09022955,-0.016182296,-0.08488841,-0.03476903,-0.0313946,-0.034557324,0.031765994,-0.040877003,0.008537468,0.042896815,0.05988901,-0.010438069,-0.058651302,-0.0011623685,0.0141246095,0.027716758,-0.07574031,-0.04382792,-0.06851498,-0.06921083,-0.05036962,0.011914325,0.052687764,-0.057416003,0.02623577,-0.08189158,-6.396788e-34,-0.017886646,-0.010173148,0.04300503,-0.08929484,0.023386035,-0.018611366,-0.046274174,-0.009693565,-0.015084548,-0.029838389,-0.032192066,-0.028638706,0.12028576,-0.0021147765,0.022929199,-0.031070137,0.011148558,0.03460333,0.06790311,-0.04522015,0.009605165,-0.0067772614,-0.030210849,0.0018410133,0.035035834,0.04189039,0.050296802,-0.00905022,0.0588825,-0.01689096,-0.04656943,-0.055474244,-0.07866918,-0.022416903,0.06624156,0.0007026188,-0.08230364,-0.036044993,0.035719715,-0.02592927,-0.01961382,-0.040602848,-0.019256394,-0.0008817915,0.020983964,-0.011978088,-0.045915145,0.07506011,-0.083064444,0.07555856,0.09850341,-0.027706167,0.025541082,-0.04692368,-0.09750281,0.045588925,0.007902893,-0.018228278,0.015473876,0.091467,0.022515612,0.01662702,-0.103183396,0.012390742,-0.02596193,0.0151183205,-0.012694524,-0.11202514,0.01994976,0.12322827,-0.047450237,-0.059138834,0.043358255,0.046607148,-0.007961808,0.024873042,0.02700944,0.048114814,0.09056702,0.038564652,-0.045939248,-0.04423177,0.032244798,-0.0741504,-0.066725895,-0.032601435,0.016332714,-0.078657106,-0.043136183,0.01960891,0.07017128,-0.053959824,-0.026425255,0.12885955,-0.02448566,-2.4941274e-33,0.052235156,-0.1386641,0.035592407,-0.12243076,-0.04613367,0.06975854,0.009583859,-0.020055057,0.008775936,0.0050208946,0.079491936,0.019024143,-0.010201195,0.030770356,0.07669089,-0.022201804,-0.028054902,0.062489558,-0.023196137,0.06252885,0.028983712,0.11453168,0.035169657,0.0580829,0.035570778,0.013008632,0.0072769937,0.08672927,0.019293526,0.03753789,-0.022549136,0.009441431,-0.058173485,-0.038997922,-0.061778333,0.026274808,-0.06517431,-0.036594015,0.052787438,0.02727663,0.059333682,0.04457054,-0.013077431,0.08194877,0.027625678,0.09386837,-0.06049101,0.11737618,-0.015348148,-0.08763586,-0.011771095,0.013915379,0.06088315,0.013390171,-0.0097390935,0.050568387,-0.020572076,-0.02286429,-0.019796954,-0.027421668,-0.06429583,-0.10228532,-0.0064344667,0.0922464,-0.0063289395,-0.025290811,0.03655495,-0.063387915,0.012555597,-0.01055942,0.009626528,0.053254638,-0.027503422,-0.017199913,-0.072472215,-0.065113924,-0.039512083,0.0044104713,0.029504713,-0.04059511,0.020699078,0.051772524,-0.005862583,-0.044076018,0.05840861,-0.035267644,0.043692365,0.12522663,0.027459318,0.07628981,-0.017235162,0.019084413,-0.081361555,0.025298262,0.016810823,-4.5568136e-08,0.02359318,-0.04849311,0.08758769,-0.09029374,-0.054882746,0.040213596,-0.017161421,-0.022939218,0.08311799,0.018239798,0.008739559,0.042254806,-0.07295303,-0.04118801,-0.04357076,0.025189653,-0.07244167,0.03348517,-0.006929172,-0.061983436,-0.034929097,-0.035360307,-0.09021292,0.043670636,0.022751622,0.013582504,0.051222205,0.018453624,-0.07176674,-0.01645656,0.022005009,0.04433979,-0.044301398,-0.017886862,-0.0917371,0.009945676,0.052675616,-0.06494303,-0.047598343,0.014762877,0.016598819,0.036764517,-0.03552984,-0.015541162,-0.06541697,0.04541624,0.033875916,-0.0032951855,-0.0025484944,-0.016904367,0.03490554,-0.01018796,-0.05520645,-0.051883798,-0.15942888,-0.011163287,-0.066507846,-0.1183597,-0.094060734,0.0078098155,0.048885234,-0.012322258,0.1688639,0.006066751 +3.5.1.131,"The enzyme, characterized from the bacterium Pseudomonas sp. ADP, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazine herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is a heterotetramer composed of a catalytic subunit (AtzE) and an accessory subunit (AtzG) that stabilizes the complex.",384,1.0,-0.07687993,0.0135949375,-0.1288704,-0.006022948,0.101469874,0.06236526,0.027846878,0.081371404,0.005786458,-0.033956174,0.03987063,0.044976324,-0.028373225,0.04961756,-0.055186585,0.07614628,-0.035821658,0.013762115,0.0059400797,-0.011709486,0.0064688423,0.07439511,-0.09251647,0.0066827233,0.031713843,0.011752409,-0.00036576152,0.02650433,-0.025985423,-0.0083710095,0.02123927,0.020786667,0.036213,-0.045698665,0.08330021,0.06200231,-0.04042668,-0.035150196,0.09136377,0.007862295,0.06278486,0.06887239,-0.08706721,-0.055950064,0.020271298,-0.0072152363,0.00082352664,0.025548663,-0.0024396135,-0.052381918,-0.018829519,-0.0015192938,0.02686271,-0.004235957,-0.08817193,-0.033173945,0.016372817,-0.024997007,-0.12480328,0.017191397,0.047240447,-0.0050316523,-0.023911176,0.032529727,0.028109673,-0.030510848,0.061001305,-0.05880324,0.06697291,-0.02218171,-0.08164538,-0.09445465,-0.06422621,0.04129619,-0.0077464967,-0.10235376,0.0032037825,-0.039424513,0.054844026,-0.08771669,0.028835302,-0.07086599,-0.009744746,0.03758753,0.06790413,-0.058536235,-0.032999452,0.051877707,0.122684665,0.009377206,0.02995858,0.0616949,-0.021497587,-0.04294782,-0.069688074,0.06971636,-0.012818505,-0.025364147,-0.005355497,0.021053059,0.054106526,0.047262,-0.051678013,-0.091006376,0.0031904278,0.02959212,0.027116686,0.066603705,0.039614685,-0.00934652,-0.059987754,-0.027217494,0.04056298,-0.015359201,0.009722528,0.051571626,0.040238023,-0.022917377,0.013753168,-0.00925922,0.02746235,-0.039962925,-0.008717199,0.101652615,0.05263727,0.03223421,-0.11124509,-6.333108e-34,-0.0010644717,0.019757597,-0.06813226,0.0016010469,-0.0430038,0.03381543,-0.018491086,-0.011783859,-0.047818266,-0.03639563,-0.06378928,-0.118188314,0.0045673624,-0.016860243,-0.030971514,-0.01493139,-0.024502035,0.03287269,0.07267796,-0.0075848037,-0.025318474,0.06358893,-0.12833364,0.031964865,0.055489462,0.082306966,0.004654979,0.01939668,-0.051225945,-0.0033139684,0.03079009,-0.019950638,-0.16457364,0.0062025753,0.05540089,-0.008239194,-0.08962083,0.016025668,0.040717233,0.06286723,-0.0038127992,-0.0005654114,0.04005533,0.0444433,0.07567279,0.01631591,-0.081201956,0.16473629,0.02728295,-0.00085986854,0.021388102,-0.08422518,0.04272677,0.020997131,-0.11921308,0.065252945,-0.027734416,0.00085420924,0.043624185,0.005708295,0.06028126,0.004453531,-0.15064664,0.025577199,0.0033667823,-0.04198151,-0.004873501,-0.01767572,0.071466185,0.0805261,-0.07778415,-0.014305859,0.06727037,0.11544576,0.025275197,-0.06109038,-0.036378462,0.020185526,0.044308245,0.08097972,-0.0871086,-0.03669691,0.046708103,-0.026365696,-0.061623912,-0.036301993,0.031178666,-0.033866256,0.010833934,-0.009371819,0.12233347,-0.07791086,-0.09735698,0.045686174,-0.003033635,-9.734296e-34,0.022711378,-0.024277437,0.017149564,-0.022999905,-0.04654885,-0.0012736508,0.016712327,-0.0009950723,-0.022693591,-0.006755115,0.09368999,-0.022286674,0.0018567798,-0.0077948305,0.068416424,0.05950801,0.032391306,0.019222897,-0.009136244,0.0076810983,-0.013306432,0.021702671,0.01989226,0.052761257,-0.035815585,0.010048224,-0.009164179,0.027322793,0.087320045,0.080949366,0.016412983,-0.010407727,-0.06383135,-0.04766375,0.013139393,0.06939035,-0.046991237,-0.0024943016,-0.045347504,-0.007220487,0.043855324,0.0047689374,0.010148494,0.040797353,0.035761952,0.07771902,-0.024368877,-0.0044485736,-0.09651232,-0.09045986,0.03163532,0.016810639,0.024328273,0.0056628212,0.012567463,0.012206769,0.02276375,-0.044321578,-0.06781131,0.000940478,0.006067098,-0.002741245,-0.020101875,0.044045795,-0.002973367,0.049729094,0.03120179,0.060493823,-0.028098462,0.004845599,0.013099701,0.035403367,0.0126946755,-0.02134497,-0.13934709,-0.019269109,-0.07718447,0.0010707744,0.008324634,-0.06391065,0.037916135,-0.025850372,-0.018916028,-0.018439185,-0.060212065,-0.08818006,-0.03219139,0.13958904,0.043676488,-0.019991444,-0.033303868,0.013496555,-0.033541568,0.023992704,0.022324348,-3.9958543e-08,-0.012104971,-0.03746511,0.050346117,-0.09374689,0.017008517,0.028658785,-0.012589141,-0.009094742,0.044555966,-0.051913414,-0.034309343,0.041571822,-0.045621034,-0.01602407,0.023792196,0.02086003,-0.058828894,0.042430934,0.00997361,0.0060454193,-0.060784794,0.019222975,-0.17257322,-0.044737086,0.01910291,0.021460515,0.022495404,0.051302556,0.107322246,-0.035073906,0.038746085,-0.00089663605,-0.0061256345,0.053898297,-0.06273994,0.014001257,-0.021244906,-0.11821569,0.010644336,0.01088801,-0.0012897108,0.003292474,-0.088969074,0.010018315,0.06860286,-0.021749342,0.046104327,-0.06787571,-0.007838024,-0.052359596,0.0234331,-0.011933769,-0.0100643085,-0.00514932,-0.022114119,-0.052267257,-0.0024046726,-0.04079631,-0.049834333,-0.019959927,-0.021394327,0.049063094,0.13281724,0.014966609 +3.5.1.132,"The enzyme participates in an L-arginine biosynthetic pathways in certain species of archaea and bacteria. In all cases known so far the enzyme also catalyses the activity of EC 3.5.1.130, [amino group carrier protein]-lysine hydrolase.",384,1.0,-0.057087597,-0.105325766,-0.084479846,-0.018814784,0.115872115,0.054583456,-0.030507023,-0.028136564,0.02243085,0.007259199,-0.020583533,-0.035482064,-0.042352572,0.02337144,-0.029592939,0.064669766,-0.14935435,-0.07182485,0.026137587,-0.07635381,0.0750911,0.057879865,-0.046623312,0.005066697,0.0018108938,-0.050945282,0.047103845,-0.068194844,-0.045705464,-0.07022388,0.039400727,-0.108075716,0.07577837,-0.049388133,0.04633972,0.11034541,-0.06434603,-0.09952905,0.07651865,0.025106825,0.038396697,-0.030686863,-0.0146753695,-0.058788102,-0.03818351,-0.004323358,0.048481993,-0.026082687,-0.015740922,0.0072319075,0.010904683,-0.028252939,-0.03622257,-0.0012523081,-0.0554837,0.02305908,-0.0838719,-0.013968591,0.010896532,-0.008752713,0.05534247,0.06778759,0.017212788,-0.0015585078,-0.007806645,-0.08877964,0.0520181,-0.06042883,0.076919824,-0.0536035,-0.012667454,-0.101888925,-0.040936973,0.04476439,0.032255456,-0.011753976,0.010743021,-0.03240309,0.04807061,-0.04527766,0.018173566,-0.041362382,-0.015899463,0.08845436,0.028069094,-0.07222931,-0.0062291794,0.026098644,0.04998104,-0.013545005,0.083499365,-0.1081458,-0.005042387,0.0063663735,-0.02839772,-0.013868918,0.013935652,-0.005107226,-0.01832945,-0.027618196,-0.02557735,0.085677534,-0.0525825,-0.074834324,-0.012636247,0.02357727,0.027152868,0.13177016,0.0057151564,-0.030452559,-0.004731487,-0.02462072,0.059427675,0.04840739,-0.015312665,0.08165535,0.053341884,-0.09656155,-0.06811161,0.0052446676,0.0051088682,-0.001206731,0.0920442,0.06808691,-0.06736161,0.092890784,-0.12190036,9.8165175e-34,0.04891817,-0.014242939,-0.014104685,-0.04624408,0.008666676,0.021214325,-0.08960324,0.02000994,0.033616245,-0.028069632,-0.0575649,-0.032732915,0.10276983,0.046297062,-0.06161128,0.0022204716,-0.041761853,0.0061970707,-0.0027159816,0.052670542,-0.046439443,0.008350035,-0.025729284,0.043677717,0.035222847,0.012711964,0.06958237,0.0022779803,0.035603046,0.02735854,-0.041620918,-0.11536294,-0.09380176,-0.0042249644,0.071432725,0.018634686,0.019194776,-0.022510126,0.026860118,0.041607715,-0.03201632,0.04304484,-0.0063999873,-0.06321882,0.005965591,-0.001034573,-0.038298834,0.13802873,0.009765469,0.037779696,0.052918617,-0.06852067,0.09546931,-0.029979866,-0.017374119,0.02195304,-0.048677977,0.017592538,0.07821344,0.028999079,0.051731527,0.034285873,0.022141365,0.059491865,0.0039679925,0.048491802,-0.004928025,-0.042767454,-0.008532997,0.06906462,-0.124519356,0.0013976418,0.10092087,-0.031389054,0.009797009,-0.0592236,-0.093511954,-0.007848298,0.0024157579,0.043423925,-0.009313266,-0.083932824,0.070274726,0.049661063,0.020096088,-0.029352358,0.00827059,-0.0068609715,0.015567906,0.000938974,0.042254053,-0.038050305,-0.029659012,0.075342745,-0.025750851,-1.8621511e-33,0.08643214,-0.131171,0.01352146,-0.116821654,-0.053398307,0.04608193,0.049802687,-0.006160038,0.0370757,-0.007410311,0.07213108,0.030033175,0.012092532,-0.05922718,0.061568886,-0.05049552,-0.009377047,0.017707512,0.03037676,0.029369768,0.023541585,-0.03476952,-0.0101948,0.0112335915,0.04518019,0.005909149,-0.05831502,0.061124943,0.008778965,-0.0054285154,-0.018341344,-0.021780387,-0.03161513,-0.05843649,-0.042411324,0.06617942,0.037519198,-0.010842777,0.00088318734,-0.05242167,0.06366219,0.02406223,0.0075449427,0.06578337,0.049269866,0.07954282,-0.040992025,0.0059103416,-0.034664925,-0.094420955,0.028229699,-0.06501017,0.07554743,0.0026767142,-0.00043938757,0.03568328,-0.012158593,0.05884153,-0.013836467,0.037115514,-0.024240918,-0.035314586,0.03724383,0.011392757,0.010807536,0.0047068708,-0.06401568,0.08113074,-0.0040572486,-0.01592723,0.10509247,-0.032018013,0.04311042,0.11881802,-0.0056158514,-0.0019886692,-0.05709912,-0.0932501,0.03661093,-0.050329965,0.008911834,-0.011666771,-0.006957287,-0.03283394,-0.041441996,-0.052538432,0.030027445,0.13388275,0.020196468,0.015238233,-0.050331473,-0.041862316,-0.0566717,-0.0041649328,0.081102826,-3.181915e-08,0.031055912,0.0059344787,0.038942106,-0.008864057,-0.024273217,0.0551616,0.017303903,0.06317414,0.025232464,-0.03459668,0.036658607,0.036508605,0.015108949,0.005855138,0.010848145,0.04895574,-0.029581163,0.06623674,-0.028109968,0.015078711,-0.0133562125,0.01575753,-0.057716902,-0.0059332377,0.018495781,-0.060772065,0.021487217,0.047998145,-0.055508554,-0.07620085,-0.016722849,0.0039642225,0.01403319,0.007414723,-0.06883153,0.047557674,-0.04517708,-0.055707198,0.012236065,0.00738835,-0.051785458,0.036554206,-0.08539174,-0.030046115,0.017256644,0.053064972,-0.013311815,0.014747116,-0.018577863,0.013355461,0.03546215,-0.061174862,0.04234231,-0.060460098,-0.05602165,-0.05147096,-0.08325095,-0.09682709,0.04433017,-0.049942862,0.043760393,0.058654994,0.16149814,-0.037786666 +4.1.1.116,"The enzyme, characterized from the bacterium Salmonella typhimurium LT2, is specific for D-ornithine and D-lysine. Requires pyridoxal 5'-phosphate.",384,0.99999994,-0.053847346,-0.084278286,0.0060098427,-0.08969454,0.0762008,0.0070619006,-0.051092826,0.0709118,0.0458659,0.01729425,-0.006358826,-0.001701538,-0.059161756,0.10790609,0.0036723022,0.054198194,-0.07690875,0.01666893,0.003163025,-0.044911016,0.09787665,0.07549902,0.06807596,-0.028912676,0.026584486,0.014052913,0.058787666,0.0772757,0.008790044,-0.060798146,-0.032897815,-0.0529893,-0.020176705,-0.0848737,0.059408464,0.04530668,-0.022964733,0.016389847,0.053433344,0.024929006,0.055972498,-0.018950125,-0.04219937,0.02455811,-0.08145097,0.0026580838,-0.039324384,0.07000809,0.026154486,0.012980442,-0.038605385,-0.049782943,0.013438488,-0.044665165,-0.0019824998,0.01247708,-0.032785013,-0.037306193,-0.025340175,-0.04014422,0.052181628,0.011179682,0.065608025,0.019676797,0.04188361,-0.030366657,0.029315647,-0.085549586,0.018407963,-0.06264725,-0.027309459,-0.051655125,0.014390799,0.0916584,0.003962999,0.0055557988,0.009587306,-0.05571121,0.051907845,-0.07049001,-0.0056333356,-0.026488028,-0.0035764468,0.13768706,0.034994833,-0.001373926,-0.013060936,0.05477742,0.06322197,-0.019228913,0.018122405,-0.06328787,-0.012039947,-0.05835744,-0.01863352,0.009693976,-0.010143741,0.0008940958,-0.01176994,-0.010954357,-0.03596282,0.007824232,-0.100470096,-0.067121506,-0.06855136,-0.050172396,0.003955943,0.016149689,0.014019327,-0.07358634,0.027135689,0.028773349,0.066163644,0.0525735,-0.055203535,0.0041583814,0.0031045382,-0.024891397,-0.01664385,-0.018591875,-0.010465027,-0.077624746,0.0012730049,0.11515187,-0.04515783,0.091692105,-0.07622523,3.0770495e-33,0.084598355,0.05099649,0.03362222,0.0028424012,-0.0011921134,0.0104731005,-0.052298173,-0.012275099,-0.054812916,-0.03764122,-0.080064334,-0.10947716,0.029819047,0.03395218,-0.021641867,-0.010398637,-0.001426123,0.0156966,0.007154058,0.022749864,0.1032316,0.053404503,-0.033174604,0.08493123,0.044663064,0.07606053,0.028218107,0.053233538,0.06349029,-0.01633295,-0.0116357375,-0.12429036,-0.054485805,0.020936273,0.07139845,-0.020911628,-0.052202545,0.0019601185,-0.024766358,0.009584072,-0.020337183,0.040592127,-0.008032043,0.009465665,0.02689332,-0.051369328,-0.04292141,0.117833465,-0.044529345,0.04774613,0.033314627,0.018300965,0.05633163,-0.09044133,-0.05927108,-0.028261999,0.0037185028,0.0013162058,0.06645644,0.0024578634,0.01608622,0.06574688,0.0034258352,0.029941877,0.054294623,-0.00736231,0.0072219255,-0.089774236,0.006255487,0.07340482,-0.012708324,-0.0047233053,0.05149536,0.052626573,0.00107132,-0.048898704,-0.08540429,-0.048546746,0.05744398,-0.061294746,-0.025755187,-0.07809093,0.026511539,-0.039419916,-0.081037246,-0.026413841,-0.02644271,-0.075038426,-0.011754795,0.039701313,0.030540848,-0.078172155,-0.0590399,0.0027665514,-0.01700389,-2.8934406e-33,-0.0030273704,-0.032191448,0.057447862,-0.05191103,-0.043441672,0.048251003,0.0045205937,-0.00077756285,0.10068606,-0.02078282,0.1217886,0.002205843,-0.036163412,-0.034642328,-0.0016686216,0.053714175,0.0060963184,0.026912037,-0.002995275,0.016751794,-0.001943694,0.041955255,-0.030996729,0.060500797,0.06543043,0.09517341,-0.013540938,0.0960213,-0.021881673,0.01626671,0.0051672547,0.08779728,0.0066395886,-0.043780725,-0.016575333,0.03211815,-0.00041507685,-0.002053668,-0.0005049849,0.011905676,-0.022757802,0.048163135,0.023066835,0.06998054,-0.078201704,0.0463823,-0.037038796,-0.029432094,0.022230765,-0.05698614,-0.04588763,-0.031967107,0.055105593,-0.03294997,0.006145522,0.051980168,-0.029745111,0.0054030176,-0.07886954,-0.016911745,0.008826908,-0.084898725,0.040697694,0.040988974,-0.011625204,0.04871294,-0.04209944,0.06941552,0.021380976,-0.031208191,-0.021110723,0.03564008,0.06682839,0.027525693,-0.12419251,-0.07939095,-0.03220486,-0.018743573,0.10299486,-0.0089501925,-0.020629121,0.021922717,-0.09356428,-0.02461771,0.015481577,-0.019511066,0.025060378,0.1384451,0.0168143,0.038738176,-0.0103308745,-0.009148852,-0.03200872,0.064803466,0.1348891,-3.1918283e-08,0.105928764,-0.1062684,0.0124315815,-0.023859113,-0.00017788965,-0.018971205,-0.031215766,-0.012911745,0.09500638,-0.022551585,-0.019974735,0.10174574,-0.010103718,-0.049440272,0.039475065,0.03236334,-0.007338399,0.027031342,-0.058581896,-0.052596737,-0.008437637,-0.014696687,-0.11119698,-0.027077772,0.049953293,-0.027612822,-0.0019839564,-0.0022059889,0.034442745,-0.0040266747,-0.036879368,-0.017343834,-0.0733955,-0.03285635,-0.041841198,0.06760428,-0.09951534,-0.030121943,0.01540932,0.038671978,0.022447193,0.030938884,-0.069948666,0.042534377,0.00974845,-0.011120081,-0.08633138,-0.0045557525,-0.01695984,-0.0211048,0.009363815,-0.018471494,0.018524703,-0.04650683,-0.15108645,0.10045107,-0.042556986,-0.013883615,-0.09261969,-0.09565664,0.03077538,0.02360289,0.18944083,-0.06226432 +4.1.1.117,"The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the siderophore staphyloferrin B.",384,1.0,-0.0746112,-0.04887293,-0.14554754,-0.016113117,0.034416817,0.045971613,-0.0858387,0.014003664,0.057234313,-0.020918382,0.03710566,-0.07266919,-0.08293148,0.021637436,-0.033035044,0.019075975,-0.12095048,-0.023402978,0.0113455625,-0.013528759,-0.018439418,0.095573075,-0.03652921,0.015111445,0.015305797,0.002539866,0.028600255,-0.003313634,-0.023468794,-0.009977633,0.0006328524,-0.04351358,0.0015424098,-0.014282057,0.01772183,0.0906255,-0.02066454,-0.06087248,0.053257667,-0.024589097,-0.025935637,-0.025397962,-0.022647915,-0.035108093,-0.05335116,0.024774868,0.04511965,0.04315474,0.042662278,0.015781041,0.037875358,0.017918818,-0.07025843,-0.011640504,0.001088715,0.027373184,-0.06315111,-0.029086318,-0.0050072996,0.013792781,0.02858069,-0.024664303,0.041106343,0.018436065,0.009427132,-0.07459795,0.020369334,-0.06628786,0.030216543,0.021152768,-0.07210046,-0.066236496,0.016720077,-0.014828848,-0.015487133,0.06679068,0.009865791,-0.0074101607,0.014847283,-0.033279214,0.028860072,0.0021463553,-0.012721948,0.17347057,0.024603007,0.022598712,0.040967695,0.0004198018,0.0043230075,0.06745371,0.036408704,-0.029954538,0.008439352,-0.08925068,-0.0667088,-0.0016722383,-0.05992419,-0.0019822337,0.0034092998,-0.043210916,-0.064807236,0.033448014,0.025463713,-0.057194047,0.038220998,-0.06738316,-0.011973133,0.06619091,0.061212484,-0.026033567,0.057102904,0.08024455,-0.039997447,-0.003256909,0.024388094,0.07812027,0.04970413,-0.08655889,-0.08883374,-0.031311985,-0.023255356,-0.055592697,-0.013182251,0.045567594,-0.0792931,-0.03550104,-0.07776583,3.7530871e-34,-0.016360803,0.0013578708,0.05107598,-0.06534181,0.03351916,-0.04503922,-0.070112236,0.02259016,-0.004316213,-0.052956726,-0.04876686,-0.04704735,0.05281656,-0.0011930437,0.06114703,-0.08233616,0.0015134233,0.009537046,0.0370797,-0.07204771,0.02235655,0.06012298,-0.030311577,-0.013946097,0.011081724,0.029764066,-0.008949401,0.06781242,0.076532416,-0.027275529,0.019291451,-0.05754571,-0.038801815,-0.036633726,0.1254718,0.021933507,-0.010867289,-0.012380925,0.039419305,0.005675229,0.016783152,0.0023164495,0.0050795795,0.037955284,0.049246244,-0.041059583,-0.043523632,0.0627636,0.03611262,0.007505453,0.018497739,-0.051133547,0.11278552,-0.033745803,0.013252187,0.039702937,-0.0028541333,0.016337555,-0.018557308,0.099524714,0.013547326,0.024153538,-0.055153962,0.025986684,-0.012804849,0.04346404,0.09178896,-0.053645574,0.00085451873,-0.015025571,-0.02172228,-0.00422172,0.0519944,0.0028999632,-0.023064714,0.0428938,-0.01806892,0.014916472,0.05722056,-0.04022676,-0.04884198,0.02761195,-0.0074081,-0.07916866,-0.08103934,-0.016903426,-0.036293473,-0.06022242,0.008004453,0.011335667,0.041911833,-0.09531517,-0.040799364,0.029039852,-0.05927471,-3.2583403e-33,0.012904832,-0.19335885,0.028628057,-0.11571183,-0.062271673,0.13362034,0.063680746,-0.034123667,-0.069472656,0.024660692,0.04690877,0.0329648,-0.035077427,-0.015417235,-0.032820787,0.00951118,0.013113164,0.075402156,0.029731276,0.023496514,-0.0097749485,0.10803805,0.13013679,0.0069511593,0.04122413,0.051295783,0.038622744,0.06335403,0.015681747,-0.00757806,-0.012612736,-0.057410654,-0.04441209,-0.03181887,-0.045856126,0.04186895,-0.0013058333,-0.0044582286,0.050131496,-0.046030834,0.04367343,-0.009656445,-0.015121348,0.080423966,0.039349593,0.05963609,-0.11341499,0.09009754,-0.056517623,-0.08020356,0.022504963,0.07982695,0.048701473,0.037580177,-0.0146869365,0.038944587,0.047970165,-0.05242891,0.011216623,0.0064937337,-0.049717452,-0.0701256,0.025248682,0.055283673,0.025742888,0.039432433,0.025687344,-0.007533273,0.02086576,-0.09222526,0.09223862,-0.0146153765,-0.006481307,0.03306154,-0.06215343,-0.029899651,-0.020927642,-0.09563307,0.013179719,-0.017606134,-0.036452062,0.01309599,-0.011644698,-0.013436583,-0.022218352,-0.0824207,0.07775958,0.07344889,0.007164198,0.012495343,0.032327846,0.041060034,-0.040318474,0.062121052,0.0799131,-2.669924e-08,0.052611504,-0.035120405,0.14258178,-0.08789626,0.0059507913,0.02060116,-0.030873427,-0.04447598,0.022136103,0.0024189674,-0.076502085,-0.0032424764,-0.042790003,-0.045478106,-0.03095666,0.035449427,-0.057172153,-0.01710627,0.014842081,-0.05989964,-0.054173756,8.042937e-05,-0.06474604,-0.024777027,0.047487065,-0.04102426,-0.026365433,0.06564027,-0.044807512,0.011865114,0.024617892,-0.0102012195,-0.036637675,0.015087227,-0.039217338,0.035084035,-0.025998808,-0.0802741,-0.04417548,0.10491499,-0.008822845,0.045404907,-0.051378746,0.028586041,-0.025236428,0.06832787,0.012956194,0.050708234,0.0020432964,0.046082165,0.050851975,-0.052265145,0.024711458,-0.050569177,-0.17343923,-0.006264192,-0.021321474,-0.10356901,-0.03334118,0.10808339,0.030464785,0.08967362,0.12174517,0.07683064 +4.2.99.24,"Isolated from the plant Papaver somniferum (opium poppy). The reaction occurs spontaneously when the pH is between 8-9, but the enzyme is required at the physiological pH, which is close to 7.",384,1.0,0.018287675,-0.01901667,-0.116323575,0.010054396,0.064878725,0.11661985,-0.071076944,0.04838501,0.02833701,-0.038228337,0.06570477,-0.018340964,-0.009242872,-0.030658776,0.00372726,-0.020042589,-0.024320612,-0.038289264,0.025913404,0.00403189,0.09080106,0.0041178027,0.0615569,0.011866934,-0.018153775,0.10231764,0.016759843,-0.012290509,0.056768075,-0.11848805,0.04592271,0.07765125,0.0040975004,-0.019211052,-0.052204583,0.012274324,-0.07201667,-0.024730153,0.13643305,0.02450302,0.081032224,-0.04379865,-0.022856884,-0.08135005,0.024324223,0.027887013,-0.03073487,0.017775493,0.03627869,-0.059555348,-0.013408334,-0.012369519,-0.01762765,0.070054315,-0.02930411,-0.05555309,0.040648293,0.043449752,0.024121517,0.052117933,0.0015669398,0.06869771,0.022404691,-0.0078578135,0.019456869,-0.02229863,-0.02816076,-0.012638357,0.07822123,-0.029682206,-0.0074938633,-0.005617503,0.07775053,0.042931836,-0.045051154,0.051628042,-0.02470501,-0.011718587,-0.020198336,0.020001935,0.11039742,0.016894827,-0.03698399,0.08976593,-0.0110827545,-0.004924908,-0.03892815,0.13884301,0.0531504,-0.01445095,0.020903464,0.06259622,-0.12358751,0.03231958,-0.02998044,-0.0070911995,0.051263724,-0.011204076,-0.02186044,-0.023651123,0.036208812,0.009087182,-0.037999548,-0.09154326,-0.020322312,0.029420264,-0.050746582,-0.044036772,0.062061068,0.061135776,-0.03774381,-0.07545973,-0.033769567,-0.06583953,-0.054762498,0.0064266236,0.046138007,-0.078168176,-0.061818164,-0.07959472,0.0010596843,-0.019943178,0.042685285,0.04562944,-0.03259863,0.002501344,-0.11805381,-1.5345996e-33,0.02802088,0.048970807,0.034271378,-0.015748827,0.008813658,-0.05460016,0.05257913,0.016426608,0.001441056,-0.0968566,-0.04479607,-0.09109197,-0.06174123,-0.027537907,-0.00737383,-0.05092392,0.0071601705,-0.079498984,0.03960466,-0.09794952,-0.019311516,0.008103525,-0.10158074,0.026185874,0.009972371,0.0638978,-0.052767713,-0.063225314,0.07909604,-0.024659872,0.08417594,-0.014181571,-0.07427909,-0.005992109,0.067242526,0.0005973087,-0.058016736,-0.012200954,-0.047255695,-0.010443159,-0.016570278,-9.025257e-05,0.1325243,0.015468402,0.015929468,-0.035648517,-0.07585474,0.017903792,0.13429332,-0.019137483,0.01844371,-0.029958168,-0.019720903,0.00854737,-0.058407847,0.01864674,-0.037663635,0.006048156,0.009770376,0.062837444,0.058710776,-0.0017141771,-0.03497062,0.051803462,0.03837761,0.02947547,-0.12271754,-0.0074426085,-0.021338891,0.05853763,-0.004345698,-0.0023940129,0.028229779,-0.07879128,-0.009314374,0.06188341,0.033660382,0.03933957,0.037962765,-0.0074673896,0.04409217,-0.049071644,-0.0068398123,0.04375612,-0.07012906,0.04534662,0.03371909,0.05318639,-0.03784903,0.09810492,-0.0035641803,-0.090948194,-0.019397097,-0.060543023,-0.0061385008,6.172088e-35,0.0641288,0.0093020145,0.029609036,0.0053968,0.011876185,0.1098804,-0.0071570654,0.11296908,-0.019015113,0.0992809,-0.016526584,-0.024122816,0.16409077,-0.034433413,-0.014504099,0.057799313,0.027702942,0.14904207,0.009189685,0.015828187,-0.04138245,0.07146673,-0.020875998,0.040181935,0.0006774412,0.0045075617,0.05787035,-0.026069172,-0.010836833,0.05348134,0.03136439,-0.022422612,-0.107398294,-0.016010014,-0.046964042,0.037937533,-0.061957825,-0.05570965,-0.01103643,0.026435107,-0.078915,-0.06414089,0.024239972,0.027992535,0.037174955,-0.02019559,-0.016378531,0.012571258,0.09143359,0.037189696,0.008358442,0.055424448,-0.039929856,-0.020298908,-0.03704413,-0.028116345,-0.014153139,-0.02858552,-0.057820197,-0.11496828,0.026265945,0.028127195,-0.10623786,-0.09424221,0.023374625,0.04223369,-0.01983153,0.029605234,0.041898396,-0.028872298,0.04149547,0.040538248,0.020517517,0.04185495,0.007878786,-0.038025,-0.09472598,-0.04138155,0.03618505,0.015999543,0.015691442,0.0026080583,0.029659607,-0.050910633,0.03640454,-0.027530417,0.047268793,0.07013496,0.011585407,-0.014434803,0.016770747,-0.0015443804,-0.08372966,-0.005693286,0.02102249,-2.835487e-08,0.0029220707,-0.055434577,0.032754287,0.0051101553,0.011864691,0.026333302,0.008728561,-0.1019863,0.014006481,-0.05238879,-0.032002345,-0.009299704,-0.026416143,0.049389943,0.021820985,-0.06700936,-0.025003634,0.104542874,-0.016114505,-0.067388296,-0.07342739,-0.02361213,-0.022713605,-0.045980506,0.048841104,0.045476787,0.025649313,-0.016578982,-0.014441123,0.0022376927,0.07900952,-0.020482494,-0.077892125,-0.057894815,-0.026781999,0.08217614,0.044973884,0.014788742,-0.032742295,-0.018258195,0.028655492,-0.07476301,-0.049818274,0.062215753,-0.037455626,0.010135614,-0.0002286565,-0.061864384,0.00341065,-0.02023497,0.041399684,-0.013712452,0.030888818,-0.04619296,-0.05321728,-0.032225054,0.00038584607,-0.050073355,0.009049723,-0.085968666,0.020998986,0.03154367,0.13826,0.10615855 +5.1.1.24,"The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.",384,1.0,-0.043470457,0.0053226277,-0.11784927,0.02729313,0.0327196,0.030028898,0.0058451463,0.0036022877,-0.010111144,-0.040680833,-0.017198062,-0.13151287,-0.020513054,-0.02822146,-0.06678539,-0.031141423,-0.10070238,-0.0067524393,0.0079509625,-0.0038156533,0.042180326,0.02481011,-0.051573407,-0.04422001,-0.018021606,0.108338535,-0.007487231,-0.08123386,-0.026762946,-0.018071845,-0.070213266,-0.060027685,0.08504369,-0.037865814,0.057716887,0.06665356,-0.03594006,0.03824239,-0.034606576,-0.02454017,0.018611945,0.023892958,0.03943467,0.010827061,-0.02127258,0.020278223,0.12256986,0.04500198,-0.04798485,-0.0068140454,-0.009240265,-0.033596497,-0.03338756,0.04080705,0.038564175,0.03387654,-0.055009242,-0.08823942,-0.0215971,-0.05784976,0.08227392,-0.039108086,0.024396017,0.0047829216,0.07160352,-0.026085394,0.059134584,-0.09070942,0.012994599,-0.049580622,-0.018543711,-0.06552689,-0.038581807,0.016890991,0.006912511,0.09445505,0.115273856,-0.05771668,0.06150206,-0.0048980583,0.0031637691,0.08743643,-0.0009202383,0.05947371,0.0535134,0.0896171,0.013849011,0.0071820845,-0.038914528,0.030274047,0.020913983,-0.046886556,-0.05094526,-0.04714194,-0.08399309,0.042527422,0.0043763956,0.002939081,0.01987743,-0.011202694,0.038676273,0.07603678,-0.022041814,-0.056513637,-0.03324355,-0.065720126,-0.041545607,0.0835865,-0.010529304,0.037483785,0.03897806,0.025336297,-0.044171784,0.033826377,0.023828445,0.08242779,0.052212063,-0.06986494,-0.077269465,0.032270525,0.0050083897,-0.024353065,-0.027481083,0.059448224,-0.026009236,0.01136913,-0.09413323,-9.891257e-34,-0.03815348,-0.013110412,0.032339904,-0.070863634,0.07574447,-0.032353904,-0.06889549,0.002929367,0.024273936,-0.051348075,-0.053984553,-0.030478757,0.07936423,-0.008556748,-0.012743026,-0.016623128,-0.030490195,0.05840119,0.06775964,-0.034788683,0.009570925,0.09334492,-0.03724556,0.06069686,0.026937727,0.056759417,-0.047528695,-0.004664988,0.03894274,-0.02213749,0.03139012,-0.054079942,-0.03341885,-0.036493093,0.12824962,-0.038022943,0.022369765,-0.029150406,-0.0028190208,0.032111924,0.0052856617,0.028650688,-0.022599878,0.10505756,0.0403953,-0.08601613,-0.108982116,0.10980081,0.009157227,-0.003726126,0.023076987,-0.012694741,0.09235929,-0.030793162,-0.072753385,0.0811629,-0.04283839,0.004282037,0.034637865,0.030315312,-0.01261617,0.0761879,-0.009880629,0.0819534,0.039813887,0.02832797,0.012115473,-0.023494365,-0.001122493,0.08431709,-0.104252025,-0.02528023,0.015601683,0.035946857,-0.004538472,0.018490111,-0.040695738,-0.043473307,0.09455673,-0.014221074,-0.01668081,0.018332172,0.007841251,-0.09126652,-0.06788673,-0.07441106,-0.044334907,-0.06313413,-0.0043852613,-0.010183992,0.046341352,-0.0006041264,-0.1062993,-0.013887619,-0.040451914,-2.0252609e-33,0.051312596,-0.12702143,0.053722765,-0.089148425,-0.045593042,0.07547477,-0.057757493,-0.06689507,-0.0033084964,-0.010683991,0.07269146,-0.0010116785,0.03775986,0.01378302,0.004762868,-0.010544081,-0.014875924,0.13653618,0.027300857,0.006569646,-0.054782975,0.057846967,0.028402004,-0.05586259,-0.0069410964,0.0067179836,-0.064471856,0.0642694,0.06836231,0.011701697,0.016898958,0.019792369,-0.026215035,-0.0644207,-0.06898119,0.039011132,0.025981797,0.027056355,0.104214095,0.02175655,0.06357021,-0.01630339,-0.0056078644,0.08924151,0.041173056,0.056156024,-0.11411062,0.050740734,-0.030393604,-0.03303539,0.07744,0.041653473,-0.00317496,0.015874466,0.01838058,0.073827185,0.009597553,-0.030808954,-0.008097636,0.011655769,-0.06866696,-0.07145599,0.03186426,0.048928194,0.028989542,-0.018278472,-0.00064712384,0.04806285,0.025324916,-0.04057722,0.058623046,0.06949863,-0.0012880221,-0.041773837,-0.082307175,-0.06575539,-0.030834647,-0.017341312,0.048278097,-0.021692928,-0.036138885,0.05742984,0.09353384,0.008028832,-0.027227694,-0.069133975,0.08457263,0.1584121,0.0010413596,0.015698465,-0.05156579,-0.05069186,-0.0768395,0.038274597,-0.0029372901,-3.372215e-08,0.026955143,-0.013642516,0.06609357,-0.035351887,-0.02595947,0.07726956,-0.009902996,-0.051208396,0.031341985,-0.015600923,-0.022803878,0.024114164,-0.032745436,-0.08503647,0.012794185,0.047533166,-0.039435156,-0.04019275,0.0008781245,-0.010118248,-0.026315333,-0.0005783513,-0.03664327,0.037001193,0.016148893,-0.04697786,0.054097086,0.043211427,-0.11873276,-0.0026254288,-0.05021115,-0.004495473,-0.018329283,-0.0040087863,-0.07652054,-0.024956862,-0.012219974,-0.060150202,0.00054870953,-0.005680394,-0.016158063,-0.015321938,-0.07423842,0.023319606,-0.05347808,0.006644557,-0.03333145,0.06270265,0.010514558,-0.045125976,0.003236827,-0.007329109,-0.02008294,-0.061600804,-0.07607299,0.048805855,-0.0043871226,-0.078324124,-0.06357661,0.056939736,0.02835951,0.030974416,0.15594812,-0.0037197354 +5.1.3.43,"The enzyme is found in bacteria that possess sulfoglycolytic pathways. The enzyme can also act on other aldohexoses such as D-galactose, D-glucose, D-glucose-6-phosphate, and D-glucuronate, but with lower efficiency. Does not act on D-mannose.",384,1.0,-0.0487677,-0.090246424,-0.057257824,-0.05182617,-0.048403725,0.011805273,-0.03884467,-0.007532336,0.038529575,0.04507954,-0.02333344,0.027214827,-0.042126223,0.07287311,-0.03984897,0.049051814,-0.048978418,0.020863036,0.0348095,-0.009932756,0.16001278,0.003464053,0.007213022,-0.040706307,0.059562366,-0.005220311,0.042284213,-0.020554034,-0.055605616,-0.07421765,-0.03913399,-0.069566414,0.0035542885,-0.021515975,0.06523359,0.122041844,0.020524682,0.002111992,0.033198394,-0.058523223,0.0012419117,-0.040546022,-0.024652276,-0.0056987335,-0.01637414,-0.034244068,-0.06569909,0.077589855,0.0016950727,-0.006786266,-0.08344377,-0.077365585,0.012336294,0.030023914,0.040805597,0.036574416,0.006537141,0.024251303,0.012577562,-0.044573884,0.042384587,0.0080843195,0.03327916,-0.0051142983,0.01766584,-0.05085531,0.025102835,-0.051697467,-0.002017563,-0.052795656,-0.009538549,-0.092983745,-0.03430156,0.019056022,0.028283648,0.017621748,0.0066475305,-0.10010098,0.043864135,-0.04086072,0.0593349,0.039435364,0.094036706,0.070204504,-0.0046387212,-0.027751096,0.04186564,-0.023918156,0.048950035,-0.029343665,-0.022338439,-0.052174833,-0.06531541,-0.05533567,-0.004659838,-0.06070608,-0.026969794,0.074501105,0.040609792,-0.03723034,0.044666726,0.022692278,-0.0089800265,-0.062081415,-0.034474455,0.062894024,-0.017464539,0.07469784,-0.0019883544,-0.016272651,-0.02247136,0.07782028,0.04350822,0.02042356,-0.035469055,0.06747516,0.06177086,-0.09757159,-0.12051612,-0.0075467094,-0.052912466,-0.047348157,0.046943728,0.05800034,-0.00808839,0.065324776,-0.10552173,-1.4534136e-33,0.10494922,-0.032973867,0.062993504,-0.07356749,0.02771784,-0.016184287,-0.014146722,0.042668637,-0.06158712,-0.008860944,-0.08921334,-0.048231084,0.037131213,0.104179636,-0.019862864,0.06665795,0.04081713,-0.049024094,0.031760465,-0.02838929,0.02130395,0.0511266,-0.009415589,-0.020572063,0.074151695,0.054210085,0.01421579,0.07642635,0.026715336,0.003981416,-0.00083211606,-0.14250709,-0.03553867,0.034532245,0.049846966,0.04984104,-0.059305307,0.055228714,-0.018598022,0.032475386,0.039127916,0.0070663453,0.017285844,-0.078321524,-0.0054573356,-0.034142226,-0.006827296,0.040792447,-0.0016630279,0.08836685,0.07143658,-0.06226895,0.043371,0.00054894394,-0.025233502,0.02978594,-0.019959895,-0.033564147,0.070058785,0.032266602,0.010684429,0.014420706,-0.040967416,-0.00696377,0.04095871,0.028692417,-0.04005491,-0.006010019,-0.061651297,0.05871923,-0.12814558,-0.02972106,0.01311136,-0.011654172,0.0046925345,-0.060437832,-0.037971314,-0.00870496,0.048795562,-0.03442582,0.04812151,-0.08646454,-0.021493062,0.003723767,-0.08889748,-0.012452357,-0.0389663,-0.094210796,-0.07434805,0.033704534,-0.055246606,-0.023477415,-0.14647025,0.07857563,0.02483843,-2.42128e-33,0.091373555,-0.06195566,0.10612708,-0.06502712,-0.06148062,0.090083085,0.052233476,-0.058750883,0.08050532,-0.014651145,0.034325056,0.017903475,0.015225761,-0.03179709,-0.012390114,0.04768781,-0.037258465,-0.002281911,-0.074942045,-0.008275018,-0.016989173,0.140887,-0.018146567,0.008100677,0.047684822,-0.0189679,-0.0032588085,0.064043775,0.031373248,0.023639403,0.017826343,0.020965673,-0.008026802,-0.081093505,-0.03379167,0.012011022,-0.09747325,0.009563418,-0.013423399,-0.011629365,-0.04397598,0.01177883,0.06937952,0.0736286,0.05205762,0.0384466,-0.04672846,-0.024962032,-0.03150427,0.00031815388,0.04899191,-0.019733684,0.026874507,0.058833346,0.058294304,0.07556269,-0.0015397365,0.029443722,-0.04992149,-0.010684457,-0.046003032,-0.041132376,0.04086986,-0.03153977,0.050153714,0.032479376,-0.062388908,0.0052952166,0.041869055,0.013231672,0.03866516,-0.0018951441,-0.040344257,0.017847562,-0.09885474,4.3752785e-05,-0.14978035,0.028252374,0.02293122,0.015693095,-0.0030075961,0.033390697,0.026298346,-0.05243851,-0.010874546,-0.027234567,0.038184334,0.072369784,0.0074460413,0.035617918,-0.06799107,-0.0046075075,-0.0203339,-0.038124718,0.038806595,-3.5009055e-08,0.033166096,0.008644145,0.08022178,-0.005097246,-0.026407223,-0.008301325,0.05739198,0.055388827,0.021692775,0.04128835,-0.038882054,0.12095166,-0.005102177,-0.030851169,0.022972133,-0.038012724,-0.04288,0.004881138,-0.044640657,-0.017844727,-0.05996902,-0.026114354,-0.09893846,0.06636173,0.05648319,-0.06923819,0.06171946,-0.042363007,-0.02679149,0.04056724,0.027515993,0.048088573,-0.025941271,-0.08126924,-0.06515556,0.02494009,-0.061677273,-0.038935583,-0.0040895077,-0.012198551,0.07295264,-0.050323572,-0.020619707,0.010608006,-0.034582887,0.061065122,-0.0021431863,0.0032094303,-0.02778735,0.073896825,0.029635258,0.024443164,-0.10119629,-0.06721834,-0.10856911,0.06201588,0.010382955,-0.08328574,0.023321403,-0.05622847,0.058528252,-0.06354979,0.15835722,-0.047842417 +6.2.1.56,"The enzyme, characterized from the marine ammonia-oxidizing archaeon Nitrosopumilus maritimus, participates in a variant of the 3-hydroxypropanoate/4-hydroxybutanate CO2 fixation cycle. cf. EC 6.2.1.40, 4-hydroxybutyrate---CoA ligase (AMP-forming).",384,1.0,-0.020219566,-0.0056067044,-0.020046232,-0.0739686,-0.003739339,0.055769213,-0.078728355,0.01730454,-0.012853938,-0.029418506,0.011900351,-0.072585315,-0.038728755,0.029519642,-0.073631816,0.024673887,-0.068359494,-0.012634783,-0.0036248963,-0.039507203,0.102265574,0.07538258,-0.04307439,0.015435081,0.02981791,0.031563226,-0.003453657,-0.06809964,0.023586925,-0.09827774,-0.03679611,0.023877427,-0.0076139923,-0.082323834,0.08691863,0.06589092,0.03155916,-0.061955504,0.012211021,0.07910756,0.05442153,-0.033869863,-0.008307712,-0.031601716,-0.04893141,0.015758594,0.07841826,-0.0108181685,0.025566177,0.008448396,-0.027555382,-0.15466717,-0.03077381,0.042681925,0.06534629,0.023870884,-0.034455724,0.053596642,0.023512395,0.012858104,0.12307696,0.046751264,0.015423497,-0.0011141277,0.041312672,-0.025579574,0.027740886,-0.043822374,0.0037442746,-0.08153397,-0.035742626,-0.06661577,-0.022357913,0.005675047,-0.05499986,0.041971326,-0.031140363,-0.051086064,0.10912503,0.0027733915,0.01634985,0.056708142,0.022358034,0.021906974,0.07246053,-0.037627783,0.0071668513,-0.019365665,0.010131969,-0.008505367,-0.07262065,-0.031443596,0.07147523,-0.034417704,-0.040438313,0.0733313,-0.0069486466,0.05782819,0.05496021,-0.02288768,0.079634614,0.067570105,-0.03168768,-0.121779084,-0.05295597,-0.015245832,0.029547656,0.18989451,0.087228775,0.039238285,-0.026346833,-0.000793622,0.03876278,0.022794347,-0.016007375,0.15692687,-0.018846776,-0.04477558,-0.040293127,0.040559106,0.017753784,-0.03926888,0.03389467,0.030397652,-0.039015405,0.050098367,-0.06818323,9.77226e-34,0.11502008,-0.031751703,-0.014943151,0.0016152344,0.014503105,-0.08678597,-0.12179136,0.012577682,-0.0033288985,-0.09451496,-0.025581548,0.04674134,0.0061472496,0.047943577,-0.06828318,-0.060793664,-0.049439672,0.043595538,0.03733035,0.03770348,-0.01679918,0.024790676,-0.09354722,0.028556297,-0.01437153,0.008078855,-0.00427866,-0.033640783,0.01114572,0.0025477458,0.030853638,-0.097693644,-0.10221411,0.037707157,0.029941725,-0.09960059,0.011301635,-0.03931345,-0.10552265,0.046996556,-0.0395436,0.03943331,-0.008480993,-0.036910355,0.09756191,-0.072328515,0.0053318515,0.1008894,0.09808059,0.055435058,-0.0027627205,0.07332388,0.051200304,0.0109651545,-0.055318505,0.034864865,0.0002655735,-0.0016400252,-0.033347934,-0.042318508,-0.013735192,0.07848015,-0.0109196035,0.04128294,-0.041125346,0.04317686,-0.023235023,-0.020273577,0.063353166,0.079183415,-0.09231464,-0.03104996,-0.0025879096,0.05342844,0.0016476286,-0.08644162,0.013802923,0.013704095,-0.008856391,0.016823445,0.026465526,0.04492548,0.060968153,-0.027175711,-0.07764182,-0.027987365,0.0634236,0.047237188,-0.008444544,0.04104501,0.06291931,-0.041076515,-0.037823163,-0.0049164034,0.008779756,-7.6447554e-34,0.11561949,-0.09791465,0.013500182,-0.10384278,-0.02731681,0.019261353,0.026849924,0.0043080095,0.011632955,-0.03621271,0.08286859,-0.005290616,0.057723515,0.013853209,0.052560005,-0.059592754,-0.011683732,0.010966892,0.047805384,0.014822237,0.055098962,0.02582758,0.020118898,0.027323473,0.05647725,0.009175049,-0.0031213001,0.00045851618,0.05701227,0.0675584,0.0073514315,0.0069457786,-0.008213772,-0.026370842,-0.058492318,0.0443285,-0.06687727,-0.0072030346,-0.033867992,-0.03965568,-0.0116425045,0.011466362,0.020278882,0.080118924,0.03069925,0.015232399,-0.028663225,-0.019089941,-0.0037878563,0.019020597,0.015723847,0.010025527,-0.023575963,-0.0156924,-0.00038310274,0.030072816,-0.026893662,0.059438076,-0.029774798,0.0014629703,-0.054660965,-0.024026748,0.04213118,-0.0689097,0.033840276,0.05512664,-0.024019293,0.030115409,0.03537856,0.078197874,0.0901049,0.006082638,0.048542768,0.043154247,-0.01955454,-0.06606498,-0.043447584,-0.036423992,-0.06619851,-0.051213186,-0.054118216,0.03237553,0.006291243,-0.11197663,-4.670247e-05,-0.052789416,0.03519439,0.13748029,-0.019818839,0.034501426,-0.012624711,-0.019824801,-0.13406335,0.015432683,-0.004636803,-4.227693e-08,0.0055606463,-0.032774817,0.03759307,0.031459518,-0.0030447764,0.02548472,0.04137881,0.005466232,0.04755654,-0.03464343,0.0721462,0.06177017,0.038387768,-0.056514516,0.020918382,-0.05146528,-0.042431954,0.040780865,-0.0327881,0.022377273,-0.053817004,-0.023500245,-0.06983613,0.02787466,-0.03456104,-0.00942093,0.05724831,0.08725189,-0.004955719,-0.024877936,-0.0003202209,0.06996459,0.02818535,-0.10357605,-0.100439094,0.02347699,0.007724041,0.03726504,-0.094173975,-0.024729867,0.003926057,-0.025078451,-0.03426644,0.0126174195,0.06540853,-0.017558875,0.015965162,0.02439974,0.016303372,-0.06386139,0.016448926,-0.04451317,-0.020446133,-0.018935475,-0.081071384,0.015713628,0.017766967,-0.06924562,-0.0382904,-0.009682435,-0.042241007,0.02828779,0.17312168,-0.07491282 +6.3.2.54,"Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.",384,1.0,-0.09524438,-0.0825923,-0.115926325,-0.012731981,0.039912306,-0.04392946,-0.045301378,0.031842828,0.038684443,-0.016725117,0.026447192,-0.029060481,-0.03940503,0.04291516,-0.08063832,-0.010212676,-0.08502427,-0.017734528,0.04921747,-0.01625183,0.007936097,0.08073954,-0.045351308,-0.014827458,-0.017013012,0.023068132,0.07366494,-0.048125226,0.028855855,-0.009599642,-0.016126905,-0.032446824,-0.006794314,-0.075376794,0.081232294,0.082010396,-0.043916773,-0.01413237,-0.010234048,-0.042492874,0.02893699,-0.013871831,0.08449967,-0.026756236,-0.015342055,-0.009332156,0.024761293,0.030447356,0.027551694,-0.018877266,-0.0056592063,-0.060394038,-0.07183698,0.009639304,0.046052676,-0.016231697,-0.15706277,-0.036194522,-0.002734759,0.03066478,0.031579085,0.02942623,0.031289704,-0.038685475,0.073452786,0.018564649,0.055579748,-0.05544116,0.0043692095,-0.023506496,-0.04280186,-0.07617131,-0.04534852,0.018873721,-0.028476546,0.049077652,0.04811043,-0.015951348,-0.015077347,-0.027502077,0.015766324,0.054103445,0.08308753,0.12278427,0.063994035,0.042920843,0.013759826,0.049421087,0.0188941,0.04588589,0.025440458,0.0006989928,0.018268801,-0.030339021,-0.04039265,-0.0048520183,-0.122053534,0.03346423,-0.007153197,0.014267034,-0.039082747,0.07296659,0.005076743,-0.03251278,-0.032057844,0.0035493947,-0.013519927,0.063484214,0.056786384,0.05035058,0.07561201,0.09115575,-0.044039123,0.0063632415,0.044040497,0.069115676,0.0013911495,-0.078745,-0.015150799,-0.021373495,-0.0066590128,0.0016274272,-0.021009944,0.05085769,-0.080950156,0.035338998,-0.09619465,2.9546069e-33,-0.029566634,0.022806041,0.066312484,-0.011765365,-0.026207827,-0.00031129798,-0.095345125,0.0025660242,-0.0052056503,-0.048838362,-0.069770105,-0.058415197,0.013782796,-0.011890738,0.06703024,-0.066797115,0.015253866,0.054546192,0.06401566,-0.017187921,-0.027391301,0.117367946,-0.03889561,-0.012817629,0.05153453,0.10054806,-0.0033248896,-0.057883874,0.111041166,-0.040014055,0.038509954,-0.08579033,-0.041789997,-0.026005792,0.09772014,0.007232432,0.007447255,-0.027934138,0.0101971645,0.062822714,-0.048668243,0.02356341,-0.038645804,0.0106239775,0.059826292,-0.06013597,-0.01485983,0.062203586,-0.015874902,-0.014734335,0.026569508,0.016333587,0.03443214,-0.011621428,-0.074471794,0.034835484,-0.012886476,-0.01218268,0.0418557,0.032038014,0.017222812,-0.026933888,-0.028112298,0.007437378,-0.014314955,0.0415905,-0.037252463,-0.12666568,0.049496505,0.045555614,-0.042772435,-0.0037014398,0.05145317,0.052291784,-0.00796835,-0.061496478,-0.06755015,0.037735965,0.09763678,0.056970496,-0.005737542,0.060250908,-0.03131887,-0.06016905,-0.027992189,-0.06181045,-0.08774178,-0.044325367,-0.005762172,0.017162383,0.028717382,-0.061554305,-0.090976134,0.03470884,-0.003939108,-4.7687352e-33,0.020218933,-0.1418873,-0.0023986488,-0.10177559,-0.08091945,0.0767684,0.060828652,-0.0604854,0.0030269779,0.004232137,0.10173818,0.003325172,-0.024023699,-0.051885687,-0.0071509923,-0.07777845,-0.06403376,0.06924172,0.01668022,-0.03036099,0.037102103,0.11246185,0.09310803,0.01368397,0.011791332,0.07218408,-0.03296822,0.11218161,0.057681784,0.04768436,-0.009705083,0.026990693,-0.05659321,-0.043960314,-0.059512526,0.07384292,-0.03282504,0.017061971,-0.00798683,-0.025560366,0.04696893,0.07287122,0.039933793,0.09755206,-0.003064183,0.08499412,-0.081001006,0.11035245,0.008572162,-0.09437723,0.034609735,0.055763938,-0.039514832,-0.003693261,0.016853727,0.0122277355,0.017621785,-0.028174266,-0.025593948,-0.0016286445,-0.047603756,-0.096383974,0.037475318,-0.015481843,0.03781984,0.0016232169,0.025061766,0.03332597,0.058872264,-0.031571962,0.06219498,0.006999934,0.046663336,0.0009902836,-0.040142786,-0.05458052,0.011860314,-0.07572977,0.07698988,-0.12751569,-0.042753983,0.01219689,0.036466647,0.007909763,0.0024071962,-0.07950122,0.08245338,0.091994666,0.045169942,0.005880654,-0.010484185,0.00068225997,-0.041698743,0.058503173,-0.056392014,-4.10255e-08,0.02212877,-0.08010353,0.0364577,-0.07312046,-0.01611135,0.0556896,-0.06330783,-0.063656315,0.04132934,-0.012021886,-0.019816,-0.011339064,-0.049965862,-0.043449476,-0.013538997,0.030476743,0.0034063829,-0.013169508,-0.027937919,-0.07141216,-0.059473734,-0.0008731339,-0.113183364,0.014978544,-0.021506209,-0.039503705,-0.0024729108,0.07782284,-0.048096064,0.055393744,-0.025972605,0.024927633,-0.0065159653,-0.0054908623,-0.026141718,0.022698382,0.008008825,-0.020615771,-0.02655589,-0.041076403,-0.053450294,-0.0066125393,-0.011499291,0.0115598915,0.010889204,0.019561503,0.02302247,0.012413929,-0.014690019,0.072434664,0.013352894,-0.0597714,0.020100923,-0.025806148,-0.113847606,-0.015456512,0.027686046,-0.13103305,-0.018046647,-0.0067451736,0.04087106,0.015185561,0.15108468,0.075763285 +6.3.2.55,"Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS). Type C NIS enzymes recognize esterified or amidated derivatives of carboxylic acids. The enzyme likely forms a 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate adenylate intermediate prior to ligation.",384,0.99999994,-0.0698111,-0.08149826,-0.10688062,-0.0025331709,0.008820424,-0.037141595,-0.07656883,0.015557677,0.02532105,-0.02542942,0.03324927,-0.057143886,-0.04350894,0.041397203,-0.07946705,-0.0007362542,-0.08432592,-0.0059843417,0.05216535,-0.006650562,-0.035408597,0.084943764,-0.032209583,0.0040919147,0.0012098294,0.012398549,0.07370322,-0.035949346,-0.007894739,-0.0051123747,-0.011664068,-0.050100766,-0.008158975,-0.07839931,0.09108603,0.06811972,-0.039917227,-0.0077582826,0.0024388449,-0.05564132,0.0070649153,-0.039072566,0.06531688,-0.014386304,-0.0108109955,-0.0025410864,0.031128047,0.034271467,0.047079567,0.005162382,-0.002394565,-0.055619154,-0.079298005,-0.026342792,0.039500568,-0.014236557,-0.16723035,-0.022988262,0.024870174,0.05265879,0.036757834,0.021721214,0.033866778,-0.041674368,0.053169306,-0.006249331,0.047880232,-0.07804602,0.025255714,-0.01821763,-0.051748745,-0.09202936,-0.024953721,0.015473446,-0.041627955,0.04983597,0.04459137,-0.03590722,0.035062037,-0.028955195,0.01586586,0.025644531,0.063204296,0.14312138,0.03140706,0.03678426,0.018812474,0.057811733,0.021260848,0.058618158,0.036404084,0.006493831,0.034882154,-0.038214162,-0.045403123,-0.02507412,-0.106178574,0.043493856,-0.008122079,0.018671287,-0.056403708,0.05375471,0.020888647,-0.028868891,-0.0008098919,-0.012305107,-0.04500084,0.07838556,0.07062904,0.030987797,0.078816,0.110835835,-0.061533794,-0.02249212,0.02015274,0.082556956,-0.0043870895,-0.09134479,-0.049398433,-0.0091914795,-0.008624954,-0.03565319,-0.02644062,0.035775226,-0.074079335,0.004808412,-0.08381034,4.869817e-33,-0.017368764,0.030988537,0.090899736,-0.02269834,-0.013313834,-0.007997032,-0.09068379,0.0020368858,0.009413909,-0.038791303,-0.05337426,-0.06318119,0.01139618,0.0033066934,0.058811955,-0.078953795,-0.005915958,0.038336243,0.049075376,-0.03208386,-0.029515877,0.11925281,-0.027045239,-0.028586177,0.051216338,0.06345607,-0.008238033,-0.042166855,0.15774913,-0.025930218,0.039110683,-0.09740272,-0.036606897,-0.048358556,0.092908904,-0.02747719,0.015522184,-0.04424287,0.043195408,0.042855617,-0.044374056,0.023578914,-0.029791446,-0.0033097633,0.054097828,-0.053736277,-0.010504681,0.06419405,-0.021622004,0.0041402774,0.04334532,-0.007592206,0.037887264,0.0012865349,-0.03919273,0.017297123,-0.039409075,0.018679984,0.054428563,0.055537317,0.048414476,0.0018341636,0.0030582247,0.001821171,-0.029745571,0.019740317,-0.02580559,-0.10581411,0.040407278,0.021348333,-0.018494662,-0.0076268283,0.07438356,0.034900025,-0.029183434,-0.045801617,-0.037409592,0.04448234,0.10054454,0.020490771,-0.020725293,0.0793361,-0.009439084,-0.04101711,0.0060881535,-0.037000448,-0.095641345,-0.05418408,-0.027256418,0.030057678,0.016834285,-0.053301334,-0.09336527,0.028292665,-0.022885876,-6.3738015e-33,0.027475098,-0.14692976,-0.0136234,-0.11934815,-0.082238175,0.06581481,0.061916444,-0.038644705,0.0038059512,0.004626511,0.11263739,0.023806198,-0.008975758,-0.04528485,0.0033282044,-0.093264215,-0.05056457,0.07223148,-0.013052491,0.0010273258,0.044229057,0.08696561,0.08015315,0.016167505,0.02167587,0.06489139,-0.019522209,0.10373171,0.057777923,0.061847243,-0.017012125,0.027187277,-0.049634036,-0.034825314,-0.022031136,0.06669996,-0.012963069,0.0025954824,0.004260571,-0.037565805,0.01732102,0.047137637,0.005875806,0.096279755,-0.0010366716,0.085634574,-0.0646032,0.10944233,0.02262572,-0.109655134,0.022559626,0.037399672,-0.027657947,0.010304933,-0.004265389,0.011872264,0.04296437,-0.034884177,-0.009619536,-0.0057865055,-0.046123974,-0.09330703,0.056955606,-0.025649697,0.03503795,0.028815366,0.03500617,0.011702425,0.055372626,-0.04981894,0.06373106,0.006832084,0.037842456,0.018314369,-0.041745484,-0.026393874,0.029200356,-0.085053585,0.07028662,-0.11034801,-0.011043731,0.019610425,0.038184915,0.03126706,0.024584426,-0.08319192,0.08247403,0.071189485,0.026744118,0.01772111,-0.0074091055,0.0048842416,-0.047002256,0.065173,-0.0516534,-4.327255e-08,0.034572516,-0.08083472,0.06477209,-0.1116223,0.0037796274,0.07322105,-0.092144206,-0.073981084,0.03618632,-0.027292155,-0.015428524,-0.004972708,-0.07022048,-0.03863132,-0.03673954,0.016899366,-0.016266925,-0.004512819,-0.02654177,-0.068108924,-0.084196314,0.0044288966,-0.08879491,-0.01835616,-0.010366747,-0.046149876,-0.0027573407,0.084617645,-0.040833298,0.038981423,0.005346526,0.005272319,-0.012067072,0.0017235207,-0.024823416,0.011564681,-0.029450588,-0.017226476,-0.052293457,-0.008592471,-0.028195,0.0058257086,-0.0005366868,0.029227674,0.0115406765,0.026734,0.00955659,0.031129993,-0.03217569,0.07596533,0.036714118,-0.055237234,-0.002793201,-0.03512974,-0.11723283,-0.0127212135,0.013610633,-0.1261654,-0.034440607,0.020273449,0.031392574,0.030578678,0.13576554,0.07892549 +6.3.2.56,"Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type B nonribosomal peptide synthase-independent synthases (NIS). Type B NIS enzymes recognize the delta-acid group of 2-oxoglutarate. The enzyme forms a 2-oxoglutarate adenylate intermediate prior to ligation.",384,1.0,-0.08512035,-0.07839988,-0.11926833,-0.014672107,0.02309533,-0.02822171,-0.049465727,-0.0055116615,0.026995078,-0.026292916,0.032235373,-0.044523817,-0.06135646,0.03794157,-0.062023737,0.02233277,-0.09308743,-0.008916948,0.029799752,-0.019773418,0.006122251,0.088065974,-0.010229101,0.0068305763,0.0015755096,0.0061556925,0.04297971,-0.05640132,0.005185949,-0.033336792,-0.0059552025,-0.048693437,-0.02711092,-0.08241159,0.09113567,0.052268643,-0.019732414,-0.01805623,-0.010099197,-0.02852771,-0.016649742,-0.039845448,0.046367645,-0.029691836,-0.013086694,-0.003822109,0.03721175,0.021166636,0.04341378,0.0009958888,0.0017531152,-0.043284636,-0.094269276,-0.022784669,0.043114122,-0.009421653,-0.14772986,-0.009341889,0.017512003,0.04003048,0.033686947,0.024579912,0.021749286,-0.037857164,0.075721055,-0.015932577,0.057488244,-0.079920985,0.02050385,-0.0034447396,-0.06601973,-0.083304845,-0.03783753,0.0042136186,-0.026380317,0.05266578,0.05632648,-0.014013538,0.012019347,-0.025668418,0.03071843,0.027084397,0.060701307,0.16813618,0.032000855,0.03422265,0.01183437,0.05371651,0.020457175,0.045564868,0.036482144,-0.0067276424,0.032390803,-0.048435375,-0.03193848,-0.010137095,-0.1135735,0.0664765,0.013734885,0.009372573,-0.07278337,0.04399484,0.03572665,-0.026569512,-9.589583e-05,-0.032016333,-0.035005316,0.07985572,0.1069616,0.012752699,0.11850385,0.09759906,-0.06027547,0.021273548,0.04723557,0.06696157,0.018778361,-0.09809675,-0.06011467,-0.03354729,-0.0022294105,-0.027432617,-0.02373556,0.031621657,-0.09169936,0.011370132,-0.088146985,4.330485e-33,0.003601392,0.027072404,0.091614164,-0.022511093,-0.025490405,-0.0018575201,-0.07447664,-0.0065306975,-0.013677623,-0.025336327,-0.0733967,-0.0608994,0.011979055,-0.0008565869,0.05010455,-0.08950456,-0.0039199004,0.031819135,0.050923325,-0.03145562,-0.008818806,0.11619104,-0.028024435,-0.046126023,0.048247613,0.06467551,0.00084136816,-0.026516976,0.10643408,-0.024674071,0.05503824,-0.101634584,-0.050631877,-0.039664634,0.07110907,-0.038228836,0.0014198266,-0.022879386,0.03720829,0.015300643,-0.04552095,0.029340528,-0.047520228,0.029686555,0.07190481,-0.034177575,-0.017436063,0.059038788,-0.004304099,0.0068713375,0.012685521,-0.008057104,0.04868084,-0.013452086,-0.025035243,0.024446,-0.002911289,0.014174167,0.044511806,0.09551746,0.04383073,0.016682064,-0.023298776,0.009478713,-0.033374693,0.032509603,0.040753037,-0.08747384,0.030096259,-0.020257022,-0.011138245,-0.022865793,0.08050585,0.016773373,-0.010735869,-0.04690181,-0.018649163,0.03971993,0.077053934,0.0012782286,-0.011270967,0.045551907,-0.014429423,-0.036856662,-0.0370361,-0.03596966,-0.06800238,-0.0499582,-0.021894315,0.032529134,0.015095597,-0.069971286,-0.069901854,0.02656397,-0.020978551,-5.191449e-33,0.02693412,-0.15201324,-0.0074874363,-0.13484712,-0.09237412,0.06481746,0.10787411,-0.03947567,-0.004040225,0.029425886,0.09906118,0.030159058,-0.020106291,-0.031544548,-0.00056681235,-0.08369482,-0.052845795,0.06712152,0.012843186,0.009417884,0.047188055,0.12965003,0.091966175,0.034462955,0.03708532,0.06656248,0.007816091,0.10626959,0.045794047,0.017498912,-0.02870762,-0.0002948445,-0.039795835,-0.03992265,-0.052312564,0.038226914,-0.01840159,0.009240776,0.003996797,-0.033842202,0.010577776,0.047460094,0.0006084423,0.07749564,0.014173787,0.0786759,-0.089500256,0.105578996,0.002479525,-0.09803893,0.025255758,0.0646783,-0.018666672,0.0060664047,0.013443555,0.004722765,0.025714401,-0.031237975,-0.013403481,0.015740918,-0.060260825,-0.09615522,0.059111107,0.01063658,0.044638317,0.051353395,0.049310874,0.0031332856,0.045757387,-0.0424354,0.07055671,-0.003447179,0.052881867,0.026265182,-0.026532177,-0.035277996,-0.00014676512,-0.094231516,0.05441749,-0.113536716,-0.046366706,0.01783712,0.03165588,0.018404745,0.028783033,-0.09602989,0.09384409,0.07862426,0.037330326,0.011520246,0.012724037,-0.0076812073,-0.024863822,0.06827087,-0.01248636,-3.9525098e-08,0.012691392,-0.056679312,0.088676065,-0.09330642,0.011207475,0.06017938,-0.056285262,-0.045294616,0.051611137,-0.009832167,-0.028964972,-0.003164017,-0.038877696,-0.04123977,-0.028478453,0.016574675,-0.016216032,-0.027307045,-0.021613454,-0.093469426,-0.05381432,0.0005130767,-0.07623136,-0.019893872,0.0050174296,-0.0503039,-0.028314661,0.06992109,-0.014584158,0.016078522,-0.0050062514,0.0024101024,-0.02045933,0.015252997,-0.02749008,0.0049044145,-0.0114961695,-0.022675954,-0.044938274,0.007724155,-0.05963046,-0.015354924,0.01263498,0.029191893,0.0016534291,0.030331688,-0.007463121,0.02241239,-0.011710358,0.08825839,0.062291108,-0.083713725,0.00498463,-0.043985263,-0.16290143,-0.013174319,-0.0009859406,-0.10507569,-0.01600607,0.049648058,0.06567149,0.04577572,0.12386752,0.06402165 +6.3.5.13,"The enzyme complex, found in Gram-positive bacteria, consists of two subunits. A glutaminase subunit (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is channeled to a ligase subunit, which adds it to the activated D-glutamate residue of lipid II, converting it to an isoglutamine residue. ",384,0.99999994,-0.059068512,-0.08281942,-0.024853436,-0.04485796,-0.015344158,-0.023261739,0.010752645,0.046023555,0.031256415,0.019647907,0.06588432,-0.10160951,-0.027654398,0.1018926,-0.0006788942,-0.07871404,-0.055200078,0.010142097,-0.071876936,-0.047930144,0.10545158,0.11856568,-0.048455287,-0.03222341,0.005746093,0.057539135,0.08816447,-0.038804457,0.07533848,-0.06378637,-0.04750057,-0.09039322,0.11737819,-0.03184594,0.07334548,0.062212233,-0.0049291025,-0.01113714,0.10958017,-0.045793645,0.02828951,0.03874108,0.016671518,-0.066206485,-0.017923802,0.02683094,0.08604289,0.045536835,0.06979303,-0.049714264,0.034846477,-0.08427119,0.00093107787,0.053787787,0.04510952,0.03736836,-0.05097241,0.003991324,-0.08178555,0.02894302,0.02416563,-0.04114118,0.054586254,-0.07418604,0.061078817,-0.040983763,0.06968762,-0.073672675,0.030945253,-0.058399804,-0.038700316,-0.08661531,-0.020806907,0.051808424,-0.03514275,0.005068017,0.0047253394,-0.013280487,0.05347985,-0.0014151095,0.05993379,-0.067097865,0.08438894,0.11999305,-0.0008513261,-0.07995381,0.04537674,0.0073196283,0.0889224,0.033760224,-0.056792043,-0.04430874,0.005974993,-0.08861415,-0.06048742,-0.016987799,0.014671508,0.046243556,0.08003523,-0.004930862,0.040228304,0.037088472,-0.0038423194,-0.07503795,-0.043693967,0.029527511,-0.005755758,0.086357966,-0.0068438402,5.5492612e-05,-0.0049740793,0.09940412,0.053349715,-0.020737628,-0.043567333,0.013626288,0.06783882,-0.013916841,-0.09398841,0.062304102,-0.006456945,-0.06350723,0.050940644,0.07558104,-0.06740198,0.047225367,-0.07348579,-1.3401055e-33,-0.023190424,-0.01148034,-0.022774763,-0.04751246,-0.011511562,-0.015695363,-0.07129354,0.00821208,-0.015235036,-0.046561606,-0.085254736,-0.07858449,0.0054290667,0.046801943,0.030189723,0.02952235,-0.07707591,0.0038062541,0.049822386,-0.027365489,0.0037411973,0.047514953,-0.0059163976,-0.035363946,0.068468735,0.038647372,0.016716098,-0.007607263,0.010547139,-0.020521034,0.02635261,-0.115237966,-0.106397934,0.028538931,0.04839738,0.015793812,-0.033884842,-0.047527444,0.00035006859,-0.01211273,-0.001102437,0.03635949,-0.019142304,-0.0050764307,0.032112833,0.009199297,-0.030063171,0.022644894,0.032568473,0.067950204,0.035025813,-0.030865537,0.044069447,-0.06615328,-0.06867501,0.015586244,0.028759412,-0.0076128677,0.043567177,0.065290086,-0.00086294336,0.10118475,-0.1003865,0.01894954,0.020244252,0.066719964,-0.066232964,-0.029821662,0.071816236,0.061772488,-0.037704185,-0.048364487,0.0037622268,0.03506983,-0.032301895,-0.07186947,-0.04677192,0.020816885,0.030616308,0.021328636,-0.024119025,-0.03007529,0.028211694,-0.015638594,-0.05338327,-0.034521595,-0.017726356,-0.07121377,-0.06660977,-0.0008329023,0.020199029,0.008992642,-0.049086593,0.06817872,-0.016031906,-1.2308299e-33,0.079821914,-0.09413372,0.037202887,-0.09313688,-0.08314786,0.0944465,-0.042162914,-0.024274472,-0.0076316018,0.01076157,0.03574381,0.0002597602,-0.024858195,0.06330498,-0.0059679556,-0.0028413686,-0.011927409,0.047276914,-0.0034604012,-0.035089377,0.038658157,0.010284675,0.039977074,0.045604497,0.01424901,0.010417053,0.013137994,0.06472498,-0.029876962,0.057459954,-0.009810622,-0.007730283,0.008643952,-0.050824407,-0.031428114,-0.041766617,-0.010631154,-0.054330025,-0.025246408,0.00037019036,0.019750092,0.087372325,0.048907388,0.06794965,-0.04643895,0.05883912,-0.00509581,0.0041805636,-0.09174891,-0.05594268,0.026773274,-0.02644337,0.010782825,-0.033937804,0.0019369363,-0.012255134,0.03374373,0.0046669883,0.0041150576,-0.0060669445,-0.06314273,-0.10712506,-0.024519207,0.025338754,0.03241444,0.012049041,0.05669467,0.011802994,0.015379119,0.001737641,0.027253969,7.534662e-06,0.07426115,0.0028386344,-0.027088748,-0.012746773,-0.03383656,9.828164e-05,0.056850445,-0.11527908,0.05969998,-0.040144887,-0.009708372,-0.075963825,0.055155654,-0.053324856,0.025153859,0.1710605,0.022642346,0.06894236,-0.019290011,0.06343681,-0.04652474,0.033245828,0.09374696,-4.2377355e-08,0.049903378,-0.040921208,-0.034524918,-0.059615776,-0.012871997,0.0790463,-0.06942396,0.026674438,0.034385797,0.0067156292,0.015827943,0.055550326,-0.084268436,-0.015766364,-0.009809002,0.03885333,-0.122147046,0.008502503,-0.025264658,0.013084196,-0.04326872,-0.031740528,-0.10983402,0.0662068,0.016853223,-0.055094723,0.024217485,0.050901227,-0.03821136,-0.004802039,0.004675634,0.065624245,-0.041279346,-0.025033748,-0.07389137,-0.019262593,-0.011988819,-0.030820247,-0.021425739,0.019702196,0.05804231,0.011661336,-0.07676018,-0.027023127,0.065013506,0.10189055,-0.00033937037,0.05507212,-0.03394432,0.007016517,0.026710162,0.008628452,0.0060697347,0.02302293,-0.14544712,-0.052207064,-0.06561151,-0.056581106,-0.024073057,-0.0014757789,0.08838426,0.043284573,0.098143235,-0.049205974 +7.2.4.5,"The enzyme from the bacterium Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.",384,1.0,-0.06603935,-0.05533924,-0.0729121,-0.01973413,0.071135364,0.06844192,-0.048710864,-0.019143749,0.0039159986,0.009687665,0.018401831,-0.02823046,-0.035626348,0.03680047,-0.05800551,-0.056803584,-0.099309795,0.012559795,0.028915672,-0.006757174,0.10321424,0.067314744,-0.012209336,-0.015472884,0.044474952,-0.04437449,0.052243266,-0.03357629,-0.0057274336,-0.06706371,-0.03571309,-0.04230989,-0.0064290375,0.0012644943,-0.014434856,0.054536473,-0.088645175,-0.05926966,0.097883746,0.03982112,-0.000889965,0.023011632,0.06219342,-0.04064772,-0.003033224,-0.06572837,-0.019436734,-0.03732129,0.11664334,-0.018181328,-0.0320613,0.0005448368,-0.039119687,0.002910944,0.013269487,0.023883859,-0.061169803,-0.050202668,-0.01935483,-0.011061194,0.08385875,0.05707119,0.010956067,0.0013205085,0.05779098,-0.07025534,-0.00085377,-0.011845266,0.065438196,-0.021169357,-0.08301301,-0.05461433,0.07936663,-0.01917174,0.049005263,-0.0013681962,-0.016182946,-0.0024879414,-0.03372688,0.01804054,0.02807387,-0.014536848,-0.031417027,0.07248294,0.015396158,-0.057849802,0.02206609,0.000111709945,0.015296431,0.026149448,0.054661814,-0.014041355,0.051357232,-0.02825055,-0.052583907,-0.09423532,-0.01708455,0.018370245,-0.042922083,-0.0062016994,0.016687602,0.07108706,0.010071339,-0.053373773,-0.0244685,-0.04418667,0.012613608,0.07821853,0.027448071,0.056824017,0.038352553,0.053276338,0.021039056,0.015050448,-0.035371117,0.068708114,-0.027591426,-0.1317479,-0.0578473,-0.042469755,0.028022861,-0.038452312,0.033378925,0.03315968,-0.014264155,0.058760684,-0.11669266,1.546184e-33,0.0641652,-0.022948904,-0.000264966,-0.00060963904,0.009689373,0.02924502,-0.120778404,-0.029781342,0.019468974,-0.09413593,-0.09507578,0.0030479338,0.036462884,0.0094269235,-0.07216097,-0.030809147,-0.06641993,-0.070390806,0.03927878,0.058973446,0.02579218,0.08436645,-0.008722618,0.054958303,0.03659089,0.037203357,-0.012146053,0.016334226,0.041442,0.01143037,0.0008816859,-0.099008,-0.082205854,0.065060474,0.09483125,0.0202926,0.009851611,-0.042057335,0.057172764,0.07334295,0.025518803,0.040868096,0.013244932,-0.009997392,0.04495422,-0.036657844,-0.03031574,0.11953804,-0.023435056,0.07198822,0.02048998,-0.056503136,0.016579596,-0.034232244,-0.085506424,0.0448463,-0.09049435,-0.026713803,-0.0035613393,0.08241218,0.052789748,-0.019652508,0.027817072,0.01599888,-0.004800699,0.053698447,-0.0960547,-0.05230304,0.08546222,0.04451572,-0.050086178,-0.029165244,0.07435969,0.11206063,0.048732497,-0.015767897,-0.10400408,0.00478698,0.04694988,-0.011138042,0.004064244,-0.020431397,-0.03918241,0.015444713,0.0026031132,-0.018016268,-0.026953537,0.0079983445,0.02573204,0.0020546059,-0.009767417,-0.05059434,0.007892598,0.011282881,-0.002782022,-2.7119309e-33,0.123445526,-0.106373474,0.018230453,0.0026927686,-0.0137461955,0.0073739416,0.07556298,-0.050585642,-0.040693298,-0.05136072,0.060193088,-0.019427484,0.08386071,-0.014150467,0.066117205,0.009459307,-0.05037341,0.019313425,-0.034089226,0.0045590554,-0.0022421768,0.0051227175,0.035514947,-0.042069107,0.040004283,0.018121975,-0.08089259,0.09907306,0.015150298,-0.022255309,-0.015581431,0.05315353,-0.09451096,-0.119831584,-0.12126446,0.08663391,-0.04099827,-0.025447825,0.011728876,0.029166859,0.07381167,0.012334494,-0.03408408,0.052434675,0.0866814,8.594239e-05,-0.048260238,-0.028465528,0.036161296,-0.057943102,0.021978045,-0.035073772,0.05024914,-0.051274043,-0.012268461,0.090576306,0.020203553,0.08545191,0.024611905,0.04604736,0.031298134,-0.0585591,0.009065094,-0.08044436,-0.0026242188,-0.03561529,0.04003751,0.07595447,0.070955254,-0.086495034,0.106068455,0.04834055,0.0866138,0.010456063,-0.033880666,-0.0818484,-0.08471808,-0.032961115,0.055293012,-0.06316179,-0.05508623,0.014458939,0.010087116,-0.042342532,0.025378434,0.021292744,0.039057307,0.033453636,-0.009245771,0.010553969,-0.04309363,-0.039214045,-0.058568623,0.03794645,-0.01336108,-4.144523e-08,0.069923826,-0.055449657,0.01703689,-0.05020822,0.018358864,0.08779761,-0.0446687,-0.0035089727,-0.0013802863,-0.048335727,0.04688206,0.0857772,-0.09369293,0.07848134,-0.028176416,0.08155582,-0.031210378,0.06867382,-0.047052223,0.020948458,-0.0925015,0.024302928,-0.14649457,0.104265615,0.0037498802,0.006532265,0.02960764,0.06383774,-0.025936048,-0.060717456,-0.051458947,0.02628413,0.03933261,-0.04328037,-0.07872361,-0.010868058,-0.024950305,0.017324476,-0.002669688,-0.011453777,0.027704887,0.0047347937,-0.04822262,0.004910941,-0.00034086453,0.0027287158,0.007261742,0.07585595,-0.033720456,0.029078761,0.06951523,-0.03869663,-0.008476537,-0.021609666,-0.0016139346,-0.050342128,-0.04109188,-0.07019867,0.007385502,0.051856462,-0.04734588,0.014239326,0.13584146,-0.039107803 +1.1.1.417,"This bacterial enzyme participates in the biosynthesis of bacterial sterols. Together with EC 1.14.13.246, 4beta-methylsterol monooxygenase (SdmA) it forms an enzyme system that removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules. SdmA catalyses three successive oxidations of the C-4beta methyl group, turning it into a carboxylate group; SdmB is a bifunctional enzyme that catalyses two different activities. As EC 1.1.1.417 it catalyses an oxidative decarboxylation that results in reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group. As EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, it reduces the 3-oxo group back to a 3beta-hydroxyl. Since the remaining methyl group at C-4 is in an alpha orientation, it cannot serve as a substrate for a second round of demethylation by this system.",384,0.99999994,0.0033419651,0.010552779,-0.11794385,-0.052080974,0.0042698886,0.036533967,-0.102678694,0.017375253,0.025453743,-0.041200377,0.0022923332,-0.04542995,-0.054773405,-0.051111616,0.047624648,0.05462403,-0.10956826,0.05559376,0.020514011,-0.01426709,0.061852027,-0.027064053,-0.04332146,-0.058980413,0.010545822,0.04202889,0.0858666,0.0011226258,-0.07093847,-0.10748459,0.05685074,0.00930119,0.09997675,-0.009159817,0.06984384,0.07537868,-0.052241173,-0.10089758,0.015011972,0.068241864,0.023143489,0.05987378,0.020883985,-0.029355807,-0.02204538,-0.042206455,-0.010293257,-0.0028244576,0.015716447,-0.077916786,0.052412316,-0.056374215,0.008933958,0.107512705,0.0049974695,-0.018151224,-0.059223536,-0.014183563,-0.06118619,-0.0057781558,0.050900232,0.00057006255,-0.00092471123,0.010389844,-0.025613835,-0.049996264,0.01558968,-0.06539722,0.031093927,-0.022791294,-0.07382059,-0.01283286,-0.004428197,0.053776454,-0.054429315,-0.019024232,0.069763385,-0.054650143,0.08541758,-0.079476856,0.02844098,0.06900168,0.056116585,0.07489356,0.05719233,-0.02181951,-0.0080844695,-0.041547757,0.035483714,0.08457651,0.03771406,0.04861246,-0.030957084,-0.012771549,-0.031831633,0.050293736,0.04406069,0.0016631337,0.03872656,-0.0026841676,0.0034922499,0.08983761,-0.09226911,-0.07335909,0.012236454,0.0044581033,0.02616439,0.10622408,-0.023004716,0.058446378,0.00026789852,0.00075945415,0.038405456,0.04242873,-0.06045071,0.08962338,0.07292433,-0.051263593,-0.0668922,-0.038783792,0.008501231,-0.011971684,0.06784519,-0.049733724,-0.01950527,0.08278773,-0.03878602,2.7936284e-33,0.09443612,-0.020162802,-0.04999217,-0.009999189,0.047272157,-0.01660407,0.009852329,0.036059324,-0.06296058,-0.032725755,-0.08578096,-0.03708886,0.052442998,0.06655732,-0.017598113,-0.066840574,-0.021664528,0.045005236,0.05037251,-0.01494511,0.0030092364,0.059833564,-0.007885555,-0.048659936,-0.018550672,0.0009379025,0.05615909,-0.01722972,0.09217033,0.013858651,-0.056334093,-0.058303464,-0.027847812,-0.015363889,0.0766652,-0.012838262,-0.03390662,-0.020907842,-0.032886185,0.07819682,0.020141315,0.011564761,-0.04577483,-0.07183142,0.0006261004,-0.004100579,-0.06422262,0.050078947,0.052997664,0.078645594,0.057788603,0.03868451,0.07908816,-0.031936515,-0.0043164236,0.015259012,-0.07053892,-0.014920042,0.046008427,0.017734554,-0.07234735,0.08265276,-0.037069935,0.024914673,0.043382615,0.014961429,-0.07155725,-0.08438136,-0.056599364,0.012752524,-0.031930093,-0.07239965,0.061915677,-0.036037825,-0.014954751,0.05309,-0.031503312,0.015172353,0.03717218,-0.057318933,-0.046893608,0.042357955,0.024501882,-0.08858741,-0.02417991,0.014555318,-0.042159535,-0.07340627,-0.021440672,-0.0037127621,0.014955544,-0.044301227,-0.048081875,0.02177343,-0.030977083,-3.993507e-33,0.05573126,-0.06669045,0.022394273,-0.12093054,-0.003361499,0.06450335,0.015058028,-0.065518565,0.04202338,-0.015393014,0.0471222,0.019805657,-0.022074634,-0.0071722167,0.060189407,-0.047539573,-0.019696752,0.03573897,-0.13415623,-0.0015015332,0.085434765,0.15367077,-0.006528143,0.10767777,-0.013954779,-0.006467631,0.0049618506,0.045298643,0.06936397,0.026834678,0.06494454,-0.02631103,0.01376315,0.009135819,0.0033046121,0.07561201,-0.055039283,-0.001104006,0.022272922,0.05811679,-0.012365981,-0.03691517,-0.060979217,0.01215253,0.086879574,0.005181057,-0.08417898,0.04723098,0.064533785,-0.007044947,-0.057899453,-0.076458685,-0.0043575447,0.03720446,0.012050695,-0.0067882515,-0.0023778323,-0.07233489,0.05395578,-0.07057103,-0.020846974,-0.0585979,0.061000984,-0.018361013,0.007364328,0.01477632,0.035485804,-0.06961784,0.04089517,-0.020744009,0.038723975,0.044526525,-0.02147516,0.022287806,0.005997173,-0.05890837,-0.041390594,-0.077655606,-0.04987983,-0.013714545,-0.02283715,0.011243229,0.07619097,-0.081204265,-0.0487509,-0.07492001,0.035697676,0.050275143,0.0024709278,0.014693326,-0.02063838,0.0069545223,-0.025431383,0.08181787,0.025660802,-4.6268937e-08,0.03556599,-0.01646681,0.04508223,0.02653582,-0.082668096,0.025623009,-0.00851075,0.023510328,0.13257143,-0.10009824,0.04410215,0.10290328,-0.01556541,-0.052909743,0.043088064,-0.014653946,-0.06651198,-0.030926373,-0.018804876,-0.07761629,-0.030803168,-0.035146683,-0.050402213,0.048642453,0.02918724,-0.019122014,-0.04415836,0.042918768,-0.003622004,-0.017013928,0.06763477,0.112215936,0.056279674,0.09746536,-0.03494704,-0.021670885,0.049139578,0.009221465,-0.0083301375,0.105918,0.03098219,-0.05054188,-0.06043501,0.03154762,-0.034091234,-0.010896737,-0.03219026,0.06762669,-0.012924483,0.012861614,0.015259132,-0.016669324,-0.07976921,0.029625991,-0.074558586,-0.017764699,-0.10624834,-0.05878345,-0.0472455,0.010830276,0.015289963,0.006549155,0.14775267,0.017791424 +1.1.1.418,"The enzyme, found in plants, catalyses multiple reactions during plant sterol biosynthesis. Unlike the fungal/animal enzyme EC 1.1.1.170, 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), the plant enzyme is specific for NAD+.",384,1.0,-0.056987647,0.031574268,-0.095330805,-0.039082672,0.01703367,0.064504415,-0.15145275,-0.0031300453,0.08536173,0.002686376,0.03980373,-0.026886156,-0.11957761,-0.08219561,-0.009908003,-0.0011049125,-0.08880519,0.057407677,0.035231363,-0.08023747,0.08500649,0.034546807,-0.0143730575,-0.026646322,0.08960927,0.007899263,-0.019443104,0.0119407885,-0.0140354615,-0.10257358,-0.03169808,-0.018556321,0.05500014,-0.02057725,-0.027191075,0.10607914,-0.073458225,-0.10640174,0.032314353,0.05050445,0.0201786,-0.019525483,-0.02874957,-0.050860904,-0.005025775,-0.046934847,-0.028656457,0.03308099,0.02994439,-0.07281869,0.035452817,-0.05185597,0.039917916,-0.017497892,-0.023255434,-0.028292272,0.060038585,0.026816377,-0.053419724,-0.026750293,0.07441496,-0.03360368,-0.054832473,-0.006726237,-0.017585464,-0.041065734,-0.028205931,-0.042512238,0.04974643,-0.035556346,-0.094349295,-0.045581624,0.00980532,0.04802063,-0.02860015,0.045775097,-0.0748949,-0.027891671,0.047670297,0.0065678693,0.08882913,0.03175596,-0.054458056,0.032308273,0.08000091,0.039213378,-0.018229764,0.06618384,0.020854218,0.025509672,0.058187246,-0.000964527,0.019447863,0.10213543,-0.10709892,0.09547163,0.06363783,0.010291637,0.014530794,-0.082856156,0.0416207,0.07863281,-0.0367356,-0.038807455,0.0452604,0.03880794,-0.06823751,0.06962285,-0.03846438,0.009868864,-0.058578596,-0.032261297,0.047810096,-0.00830413,-0.03836554,0.10293932,0.021565977,-0.061433032,-0.08024539,-0.035156243,0.027790984,-0.011151337,0.004240607,0.051836424,0.019663151,0.07724612,-0.10443793,1.200106e-33,0.107096456,0.030562324,-0.051031522,0.011927869,0.03363411,0.016726257,-0.019976893,0.090446636,-0.07223954,-0.07256907,-0.04043298,-0.07472055,0.0317221,0.013430657,-0.027897514,-0.0056584594,-0.00066857936,-0.015716648,0.052440677,-0.007902954,-0.01576493,0.030746307,-0.084265985,0.019363835,0.020652559,-0.0007924531,-0.004000587,0.0054554185,0.040562037,-0.021203933,0.029501412,-0.11679251,-0.046273813,0.013000267,0.100241624,-0.018576894,0.0012896023,-0.040053975,-0.044270806,0.080681995,-0.02990996,0.03803099,0.043388173,-0.021929283,0.045400295,-0.010333756,-0.049653977,0.07075068,0.08799838,0.0837653,0.024807116,0.056750294,0.10245912,0.025148364,0.0042963396,0.07303337,-0.04381692,0.056204088,-0.013667138,0.047113545,-0.049030215,0.0998108,-0.0149458,0.05111349,-0.03963422,0.017215284,-0.10486289,-0.065971166,-0.022368042,0.12250679,-0.027842214,-0.045778457,-0.021993317,-0.012903949,0.04587396,0.0027509658,-0.012278899,0.0165011,-0.039872717,-0.012965205,-0.044985533,0.002991057,-0.020247743,-0.029477151,-0.056650262,0.047589716,-0.035916097,-0.0464536,0.007875085,0.036093667,0.033139184,0.0056118458,-0.066357404,-0.006263072,0.044401553,-2.0950858e-33,0.08277102,-0.07675257,0.06322527,-0.08911964,-0.039107375,0.07526661,-0.056780174,-0.09861504,0.056492675,0.005076085,0.0095700715,0.043032262,0.036679804,0.007402183,0.03633355,-0.032293692,-0.037684754,0.022423165,-0.0089369565,0.0017621412,-0.029948426,0.13094763,0.029252352,0.043869108,-0.003385873,-0.032834597,0.012043993,0.012001234,0.03638081,-0.0034254228,0.05964009,-0.039187133,-0.022649962,0.036256153,-0.04691214,0.010624623,-0.036158394,-0.016460361,0.04463413,0.07085322,-0.0067578615,-0.029755099,-0.042089235,-0.0004976476,0.07363075,-0.042461447,-0.07871226,0.037598256,0.02991942,-0.033754624,0.0052173366,0.0142907165,-0.021744737,0.06761,0.06710152,-0.016945563,0.02210445,-0.014067674,0.064781584,-0.021734295,0.029468862,-0.022908635,0.03144531,-0.025450781,-0.010012282,0.025291597,0.018116403,-0.016564053,0.04372624,-0.00036143084,0.099943444,0.06634766,-0.03159186,0.0997795,-0.028924964,-0.021134155,-0.06887139,-0.04017501,-0.08865535,-0.011317715,-0.02085711,0.014141906,0.07748108,-0.08771654,-0.06351696,-0.019259423,-0.0048731575,0.109233595,-0.034829535,0.030483615,-0.0115935225,0.020155014,-0.04839617,0.05479827,0.03997314,-3.2534114e-08,0.00855118,-0.019577067,0.03880383,-0.10509371,-0.06644644,-0.004624403,0.061224777,-0.011649161,0.048344973,-0.011574172,-0.048825372,0.11115128,0.015247574,0.040952947,0.058914807,-0.014148583,-0.024336636,0.013679001,-0.03080285,-0.0009407347,-0.028659716,0.016095227,-0.105731346,0.035076644,0.025664074,-0.03852074,0.0369972,0.035381,0.043479756,0.0044869645,0.054855894,0.024739712,0.06990174,-0.0063315853,-0.02132863,0.032971945,-0.010192901,-0.041572917,-0.04133125,0.06832699,0.021600112,-0.12551737,-0.040591855,-0.007781829,-0.046262857,-0.0077270903,0.06054355,0.0008309003,0.0035300257,0.031214258,0.0592745,-0.029388605,-0.018629672,-0.03792569,-0.0716591,-0.027193852,-0.0058734952,-0.06867933,0.020076929,-0.031499773,-0.00059834565,-0.031625062,0.2042897,0.005074228 +1.14.13.246,"Contains a Rieske [2Fe-2S] iron-sulfur cluster. This bacterial enzyme (SdmA) participates in the biosynthesis of bacterial sterols. Together with SdmB it forms an enzyme system that removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules. SdmA catalyses three successive oxidations of the C-4beta methyl group, turning it into a carboxylate group; the second enzyme, SdmB, is a bifunctional enzyme that catalyses two different activities. As EC 1.1.1.417, 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating), it catalyses an oxidative decarboxylation that results in reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group. As EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, it reduces the 3-oxo group back to a 3beta-hydroxyl. Unlike the animal/fungal enzyme EC 1.14.18.9, 4alpha-methylsterol monooxygenase, and the plant enzymes EC 1.14.18.10, plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase, and EC 1.14.18.11, plant 4alpha-monomethylsterol monooxygenase, this enzyme acts preferentially on the 4beta-methyl group. Since no epimerization of the remaining C-4alpha methyl group occurs, the enzyme can only remove one methyl group, leaving a 4alpha-monomethylated product. Known substrates include 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol and 14-demethyllanosterol.",384,1.0,0.011899084,-0.008037353,-0.118463136,-0.01007764,0.029861,0.0059871203,-0.1269451,0.030319631,0.031781282,-0.044410035,-0.019380946,-0.049816165,-0.06382323,-0.06682305,0.029251894,0.0395002,-0.07219732,0.07641002,0.029096935,-0.026164463,0.08419455,-0.034925815,-0.048378646,-0.057057064,-0.0010145609,0.060694445,0.09007056,-0.00853776,-0.09631402,-0.13960664,0.05665554,-0.008226491,0.07324231,-0.014611272,0.050542906,0.08443209,-0.041509844,-0.0853349,-0.008365757,0.046231408,-0.002309006,0.02773933,0.013514569,-0.05078366,-0.033710003,-0.06272715,-0.041820783,0.0034446777,0.0075288606,-0.07010715,0.023076221,-0.05396432,-0.022223046,0.12643726,0.016081428,-0.023625797,-0.048821826,-0.013654741,-0.052602936,-0.009282467,0.057229716,-0.019028593,0.021627858,-0.007936464,-0.0072667254,-0.04059347,0.035188306,-0.08779133,0.055485953,-0.041537035,-0.06976146,0.008626252,-0.02745831,0.07353215,-0.037443675,0.0058434634,0.055546198,-0.024319306,0.094416775,-0.07223961,0.0037609474,0.073800534,0.08746269,0.061707824,0.07678459,-0.013055186,-0.017480867,-0.019003775,0.03418413,0.08262594,0.042448834,0.07008258,-0.015547565,0.015165275,-0.03830604,0.042707328,0.004412954,0.05081664,0.0341607,-0.008224444,-0.011664852,0.11257124,-0.09531577,-0.09553032,0.031540804,0.0011168832,0.0077365665,0.10115186,-0.0029477186,0.06415104,0.005153086,0.004826989,0.011322938,0.064287364,-0.047605775,0.09690335,0.10721747,-0.03691733,-0.04614211,-0.032574855,0.034948505,0.0014921644,0.01701742,-0.035653703,-0.0072786445,0.088191226,-0.076298825,2.4875648e-33,0.06456496,-0.018263737,-0.0456225,-0.0004537605,0.022621509,-0.016667971,-0.014246759,0.03341612,-0.043783646,-0.015215021,-0.07777593,0.0041473955,0.052310076,0.044121522,0.008211394,-0.07342649,-0.0053359014,0.04276729,0.06042061,-0.04302906,0.006360426,0.08150992,-0.010693145,-0.057774104,-0.009668005,0.029894413,0.046844386,-0.011407807,0.083690956,0.013242408,-0.042446952,-0.10851047,-0.009798037,0.0028330076,0.079601295,-0.027822927,-0.009043273,-0.028029375,-0.05076444,0.04328377,0.029532233,-0.008411948,-0.03669324,-0.088812426,0.013074682,-0.055120975,-0.08068184,0.046502206,0.04090155,0.06210099,0.0420629,0.048678596,0.09528209,-0.0101180915,-0.022755587,0.022579666,-0.04220062,-0.012071552,0.05222005,0.04554286,-0.073150635,0.08973218,-0.020488681,0.036383998,0.03764144,-0.008539924,-0.07930454,-0.045116268,-0.05403601,0.055902146,-0.03569652,-0.06862935,0.068633944,-0.039741617,-0.031855933,0.006510685,-0.042733774,-0.003459204,0.025791313,-0.033451702,-0.063287534,0.023181751,0.008967337,-0.06548558,-0.062991485,0.014317943,-0.06258757,-0.07997451,-0.053790305,-0.026887408,0.004314705,-0.010802318,-0.061510835,0.017389063,-0.011935133,-4.0473325e-33,0.05271553,-0.04700554,0.012699984,-0.09490094,-0.008801334,0.08240314,0.012349007,-0.06615573,0.037996147,-0.009383655,0.039893933,-0.011089647,-0.030768722,-0.05035178,0.06718764,-0.028344518,0.003381267,0.021365752,-0.10018449,-0.016113162,0.05279441,0.19534817,0.011865494,0.12041016,-0.023502795,-0.022147225,0.03155937,0.04217988,0.046626776,0.045866862,0.07311064,-0.013601379,0.021403076,-0.019684928,-0.028233325,0.041603014,-0.04630993,-0.021451969,0.03436413,0.025514297,-0.019098667,-0.05760044,-0.080060884,0.025208661,0.06534817,0.028355697,-0.062847406,0.048358303,0.071028024,0.0020166503,-0.026439982,-0.07037105,-0.020488761,0.04191675,-0.008095153,-0.013399521,-0.012914756,-0.075312704,0.042413447,-0.031267334,-0.01737821,-0.04577062,0.0694118,-0.014399395,0.010994865,0.012292721,0.02269804,-0.058459375,0.054298095,-0.007986572,0.061824765,0.06608371,-0.03859844,0.035603393,-0.016163459,-0.05950202,-0.026828354,-0.051176,-0.03751941,-0.020366248,-0.03567128,0.0069933375,0.058651634,-0.058018457,-0.010937492,-0.107066154,0.006482567,0.079312146,0.008112964,0.035637133,-0.034920815,0.0031657557,-0.04274245,0.07630915,0.007433596,-4.7432415e-08,0.034498997,-0.039952237,0.031104613,0.022419514,-0.080071524,0.0031368097,-0.016221417,0.029913466,0.085006244,-0.062209457,0.03880809,0.10002108,-0.04145802,-0.03709406,0.064392306,0.018826682,-0.020302447,-0.011082821,-0.021658964,-0.051432375,-0.0258455,-0.042153116,-0.052590713,0.06283368,0.04992476,-0.029664379,-0.021857943,0.026615493,0.0095359,-0.0063694254,0.04921992,0.084481105,0.065605626,0.10224396,-0.027905421,-0.0006197659,0.035234503,0.0009347787,-0.023943836,0.10151131,0.017480683,-0.025280045,-0.06359953,0.028610162,-0.058838118,-0.020069418,-0.046949137,0.07575075,-0.008596752,-0.008376384,0.017511643,-0.0077001387,-0.081827074,0.0031556408,-0.092022076,0.036750875,-0.07739708,-0.08712448,-0.016415,0.019984253,0.050287984,0.0017024375,0.15585779,0.0037706227 +1.14.14.171,A cytochrome P-450 (heme-thiolate) protein isolated from the plant Maesa lanceolata (false assegai). Involved in the biosynthesis of maesasaponins. It also acts on some derivatives of beta-amyrin such as erythrodiol or oleanolic acid.,384,1.0,-0.07133317,0.01838014,-0.07891102,-0.022788122,0.089554824,0.06965898,-0.029907942,0.055011563,0.06145608,0.0024292427,0.06329032,-0.033780422,-0.078159906,-0.008150009,-0.048665244,0.048464876,-0.09152674,0.0058866474,-0.027032161,0.011618031,0.020936165,0.0708893,-0.009616609,0.07453167,0.033043496,-0.019559989,0.0017795886,0.04666202,-0.044003498,-0.057710137,-0.023482518,-0.06867541,0.05641422,0.01662884,-0.018308155,0.09046492,-0.075271755,-0.10354391,0.036939804,-0.08443878,0.09807828,-0.05798909,-0.058719914,-0.043335427,-0.0163947,-0.02379541,-0.032805797,0.004969333,0.04486592,-0.008974874,-0.024647292,-0.07140774,-0.05746036,0.0027330415,-0.013986606,-0.007451658,0.04471021,-0.05284074,-0.02875622,0.014927299,0.017631201,0.08815758,-0.0040750196,-0.022616556,-0.027191577,-0.03416811,-0.054558083,-0.008352534,0.043429352,-0.06694862,0.011936864,-0.11556094,-0.008716124,0.047861975,-0.054800764,0.0578325,-0.022139732,0.026872018,0.016258836,-0.038694512,0.03788533,-0.014250135,0.01999629,0.14076002,0.013347045,-0.030165482,0.00789064,0.059180666,-0.0028310684,-0.036491103,0.01963493,0.027358511,-0.020226587,-0.027774367,-0.018683085,0.024636041,-0.00057806436,-0.026807914,-0.03460301,0.037000265,0.04495829,0.07200549,-0.0037088215,-0.14826421,-0.083599575,0.028668636,0.006285703,-0.0093529355,0.03351909,-0.07818494,-0.030300876,-0.06735892,-0.029448928,0.0020286802,-0.04338111,0.0865773,0.02442144,-0.048553333,-0.05331484,-0.019938946,-0.029718803,-0.015879706,0.104442336,0.036423836,0.0009130663,0.0024526166,-0.16055322,2.9885827e-33,0.120501,0.011281346,-0.0235027,0.0012017197,0.045240767,-0.022824524,-0.042192515,-0.016241336,0.0016401954,-0.004895702,-0.099079706,-0.071970165,0.008672558,-0.029695632,0.037872158,0.023050422,-0.04995777,0.014309355,0.08784708,0.02028167,-0.08868109,0.0066611045,-0.042260494,-0.05979594,0.018047482,0.07361117,-0.05384244,-0.023847295,0.039996803,0.032257285,0.010530454,-0.049495533,-0.07659313,-0.01779883,0.09371572,0.016889118,-0.012795912,-0.021708742,-0.065579,0.040797412,0.017971644,0.014759453,0.051751398,-0.04942538,0.065283924,0.008256565,-0.08830058,0.07883064,0.033781074,0.0293477,0.039454505,-0.11513221,0.098403096,0.0059816954,-0.043007195,0.011533431,-0.06588671,0.044983573,0.030870983,0.09227306,0.09687397,0.023992104,-0.027430397,0.05200995,0.020423813,0.07398636,-0.053825106,-0.0016846247,-0.029337613,0.062164344,-0.013389865,-0.07348947,0.07078319,-0.007501084,-0.0002539775,0.015703503,-0.0046869786,0.056330387,-0.014343953,0.023235217,0.040457338,-0.004734921,-0.008302873,-0.027446462,0.004994316,0.032423403,0.053296305,0.020024683,-0.032205317,0.041474923,0.068863444,-0.041119557,-0.012166092,0.008873868,-0.03848037,-3.8099278e-33,0.0606392,-0.10705241,-0.0074961777,-0.10133441,-0.03449261,0.046521567,0.0016902254,-0.010081799,-0.015861426,0.060352344,0.112355374,-0.07044153,0.02154772,-0.0660979,-0.0037573364,-0.022078337,-0.00716905,0.028286902,0.02513372,0.05913705,-0.03669083,0.023236271,0.047556937,-0.0060805446,0.031503536,0.022226831,-0.021992067,0.055723697,0.0016822052,-0.017307064,-0.070881,0.005654663,-0.06376835,-0.11771274,-0.057689432,0.040605534,0.012992338,-0.068611115,0.075466745,0.059837423,-0.009408266,0.071255736,0.025584951,0.028010948,0.06375264,0.056257963,-0.07245146,-0.025947263,-0.046784062,-0.020981524,0.08952403,-0.055774774,0.03577027,0.06256373,-0.035834346,0.007431185,0.018724198,0.10454169,-0.04097428,-0.0022283844,0.013603059,-0.055841874,-0.058005515,0.06855967,0.019913131,0.08448005,-0.039928928,0.04211715,-0.016843395,0.0009369088,0.073421426,-0.036344443,0.06460932,0.11294858,0.0037155706,0.008951271,-0.03674235,-0.06675263,0.0423221,-0.026287546,-0.0019547248,0.0043415762,-0.04195227,-0.065674074,-0.036843136,-0.082272924,-0.009519703,0.10654969,0.012045457,-0.020092256,0.0041332953,0.059467122,-0.02583918,0.08745468,0.029296398,-3.776445e-08,0.034471836,-0.056314964,0.018111633,-0.01893233,-0.003335985,-0.019249529,0.0018059334,-0.022076538,0.034602985,-0.008622306,-0.018422708,0.07853808,-0.056472123,-0.032643728,0.018403567,-0.016208727,0.060832404,0.086853504,0.0069117495,-0.011998857,-0.015618524,0.06890998,-0.019369092,-0.024101786,0.03884855,-0.12473888,0.00315306,-0.015897488,0.014299951,-0.033454083,0.026292505,0.04907796,-0.019569054,-0.063279375,-0.00897833,0.071665645,-0.06924109,-0.10218705,-0.01969799,-0.0047423095,-0.030475965,-0.047048114,-0.06085435,-0.06931655,0.022298576,-0.011328021,0.08666507,0.019045513,-0.026790233,-0.01696209,-0.007891924,-0.009940151,0.0593523,-0.11017184,-0.08903329,-0.052456442,0.060777914,-0.060313478,0.016455716,-0.050644845,0.021241823,0.01853162,0.17313476,0.031494007 +1.14.18.10,"This plant enzyme catalyses a step in the biosynthesis of sterols. It acts on the 4alpha-methyl group of the 4,4-dimethylated intermediate 24-methylidenecycloartanol and catalyses three successive oxidations, turning it into a carboxyl group. The carboxylate is subsequently removed by EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), which also catalyses the epimerization of the remaining 4beta-methyl into the 4alpha position. Unlike the fungal/animal enzyme EC 1.14.18.9, 4alpha-methylsterol monooxygenase, this enzyme is not able to remove the methyl group from C-4-monomethylated substrates. That activity is performed in plants by a second enzyme, EC 1.14.18.11, plant 4alpha-monomethylsterol monooxygenase.",384,1.0,0.026970925,0.044016257,-0.09852399,-0.053522315,-0.0063395347,0.041657764,-0.15341103,-0.040690716,0.06356781,-0.028891308,0.058490094,-0.008518284,-0.09561645,-0.08342611,-0.02621045,0.018442987,-0.064270616,0.062417652,-0.0053833295,-0.05988868,0.07709771,-0.011553906,-0.04570202,-0.025843112,0.04946996,-0.020172456,-0.012324486,-0.008458688,-0.045269903,-0.11429163,0.0049450067,-0.011282631,0.07086766,-0.016382637,-0.032387704,0.11052734,-0.050988965,-0.08780216,0.057644635,0.073345356,0.041282527,-0.02070412,-0.01332324,-0.067257546,-0.023427423,-0.033276882,-0.014014222,-0.0044132248,-0.0054821647,-0.097418524,0.06872805,-0.05560733,0.041385196,0.034028202,-0.051917914,-0.010926498,0.00714621,0.05394499,-0.03896974,0.02231879,0.09443997,0.015715724,-0.052756764,-0.007249584,-0.07414698,-0.025008092,-0.04223247,-0.07300808,0.034922488,-0.03564537,-0.06889021,-0.037231904,0.0037089514,0.011374835,-0.041993123,0.014513622,-0.01254628,-0.029488327,0.07415962,-0.028612433,0.09171625,0.035831217,0.030268217,-0.00066657003,0.05699845,0.03172445,-0.012735557,0.03146731,0.015153804,0.053788554,0.113352686,-0.0071056066,0.0193301,0.07287293,0.009851201,0.08565997,0.07996377,-0.017913856,0.008675977,-0.028118202,0.03625199,0.04102446,-0.08113923,-0.05303913,-0.00023379484,0.029669352,-0.011915057,0.096736975,-0.01481481,-0.0030215094,-0.047707375,-0.011996804,0.033968464,0.02076666,-0.07509251,0.09437251,0.034927633,-0.060495503,-0.05322944,-0.039668884,0.019591141,0.0025888346,0.061149593,0.012018494,0.041156396,0.10235631,-0.09373123,3.796039e-33,0.08205467,0.050944526,-0.032792673,-0.021248853,0.060136355,-0.0076331957,0.0032871165,0.08447207,-0.036312435,-0.031104388,-0.05017169,-0.084751874,0.031621326,0.017138967,-0.040891953,-0.04046839,-0.0033218684,0.026366405,0.05229831,-0.046108283,-0.005342513,0.027739499,-0.09017567,0.006859609,-0.016184678,0.0006408702,0.0107924575,-0.036396593,0.08496232,0.009628247,-0.0343461,-0.074386686,-0.07857065,8.594651e-05,0.07901368,-0.019777643,-0.0080035115,-0.0324663,-0.00813018,0.08827471,0.029100724,0.022353332,0.02735712,-0.06606842,0.04318045,-0.010303763,-0.07720887,0.09895267,0.081405886,0.112661004,0.04860628,0.0650387,0.08131823,0.026348317,-0.045757387,0.031248737,-0.057182595,-0.005911321,0.007551029,0.019627204,-0.025863573,0.08328715,-0.047644626,0.010832129,0.002956905,-0.015790747,-0.11641964,-0.05790754,-0.05559905,0.0703899,-0.03030483,-0.07489086,0.012696273,-0.030988209,0.044199936,0.034888543,-0.0098733455,0.023999372,0.0029600682,-0.032254044,-0.03788078,0.078226104,0.0294394,-0.10962852,-0.017994428,0.025142806,-0.025647359,-0.03882403,0.019365607,0.02796507,0.0040716897,-0.04074958,-0.03727559,0.016044416,0.0334972,-4.6525317e-33,0.12715147,-0.043004297,0.060398567,-0.09112725,0.0041081416,0.03542487,-0.028137183,-0.05032339,0.04658802,-0.019270562,0.025876526,0.047175296,0.037847854,0.03434293,0.06593788,-0.015497851,-0.03200813,0.053124238,-0.048436727,0.011604481,-0.0033779903,0.09573854,-0.028731229,0.12458973,0.026234265,-0.04106867,0.03548268,0.028377943,0.064501,0.03356722,0.036852308,-0.041862722,-0.0063915798,0.063895814,-0.05550116,0.0542403,-0.07387052,-3.0537034e-05,0.019838309,0.090971544,-0.04222881,-0.050800595,-0.07327518,0.0075939866,0.08806929,0.00051276735,-0.094775796,0.055203296,0.03450422,-0.014689308,-0.026469333,-0.008028759,-0.019570785,0.05910275,0.042831536,0.006951064,0.050902348,-0.034531068,0.015859002,-0.041218475,0.03275503,-0.018821718,0.02569442,-0.027840633,-0.012171808,0.014097654,0.015598361,-0.03045862,0.04352663,-0.014883617,0.06859698,0.03815974,-0.057001803,0.042939868,-0.01615244,-0.010518961,-0.03362781,-0.07151497,-0.09960154,-0.045488153,-0.017958172,-0.0030027097,0.10376225,-0.11584173,-0.07388667,-0.07413336,0.03273388,0.087175995,-0.021029599,0.019163413,-0.0025302845,-0.0038922112,-0.004731282,0.07154284,0.065894686,-4.712701e-08,0.01406514,-0.01882945,0.023424132,-0.061788004,-0.106337234,-0.0060981275,0.022644503,0.0123051535,0.071599446,-0.09832136,-0.05168278,0.08600931,-0.022486398,0.026506241,0.0643188,-0.02276212,-0.052811477,0.0028212934,-0.018693455,-0.007986313,-0.049079295,-0.00676567,-0.07001005,0.010773306,0.010369427,-0.053697117,0.01219272,0.06942633,0.02024059,0.024467101,0.062693164,0.093986064,0.068288274,0.015180862,-0.02103588,0.005107743,-0.015461702,-0.0051720976,-0.041232776,0.056379188,0.05503611,-0.10777155,-0.03408591,-0.00106009,-0.041618623,-0.059117474,-0.00085338095,0.033867877,0.025829613,0.036329806,0.037582286,-0.007435843,-0.054563005,-0.015131543,-0.033438608,-0.03266542,-0.048165355,-0.06477623,-0.018763509,-0.02171396,-0.007925238,0.007095479,0.1873172,-0.035482593 +1.14.18.11,"This plant enzyme catalyses a step in the biosynthesis of sterols. It acts on the methyl group of the 4alpha-methylated intermediates 24-ethylidenelophenol and 24-methylidenelophenol and catalyses three successive oxidations, turning it into a carboxyl group. The carboxylate is subsequently removed by EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating). Unlike the fungal/animal enzyme EC 1.14.18.9, 4alpha-methylsterol monooxygenase, this enzyme is not able to act on 4,4-dimethylated substrates. That activity, which occurs earlier in the pathway, is performed in plants by a second enzyme, EC 1.14.18.10, plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase.",384,1.0,-0.0029286202,0.033056177,-0.0856185,-0.05398601,-0.008661672,0.039610643,-0.16484235,-0.013594926,0.04907768,-0.0303847,0.06209071,-0.030587107,-0.101132974,-0.08776229,-0.011623971,0.012754073,-0.07487388,0.057389643,-0.0046025044,-0.07669448,0.071503446,0.007292808,-0.03438022,-0.029774832,0.054137517,-0.011409598,-0.011387812,-0.0064151143,-0.04106349,-0.10817551,0.002476407,-0.028958008,0.05631145,-0.020284548,-0.029073497,0.09452273,-0.04153074,-0.10361515,0.046960544,0.089482486,0.045453295,-0.033633437,-0.025506731,-0.07849517,-0.021067625,-0.04262528,-0.021964496,0.0029549692,0.010654802,-0.10270621,0.0581759,-0.06497963,0.06320143,0.022608204,-0.05073015,-0.008149319,0.0054074726,0.0506865,-0.069196686,0.004091684,0.075812206,0.0036859133,-0.04497196,-0.0041987584,-0.082213335,-0.019476075,-0.047474228,-0.05956542,0.04577754,-0.023230642,-0.07330509,-0.050928734,-0.006843173,0.017072136,-0.05062997,0.018017143,-0.009870739,-0.042022143,0.083631106,-0.042050827,0.08977286,0.032403454,0.008675331,0.013897631,0.05716673,0.016951784,-0.018560654,0.052507184,-0.006479762,0.071366444,0.10408751,-0.010633386,0.023027057,0.08058463,-0.0030999084,0.09031151,0.07966096,-0.0135651175,-0.022053514,-0.045334768,0.03701564,0.062004,-0.06463082,-0.04918661,0.010158145,0.028218748,-0.025382273,0.081062615,-0.023923295,0.0041911053,-0.04025242,-0.03077183,0.048287697,0.01802385,-0.057384547,0.106389925,0.024889793,-0.068969764,-0.06201594,-0.034561895,0.02980172,-0.015801461,0.051343013,0.042199943,0.023009524,0.102813326,-0.08306242,2.961098e-33,0.080716796,0.0286284,-0.038792286,0.0024373643,0.05710842,-0.0021367874,-0.013803565,0.10038462,-0.07047475,-0.045587815,-0.043660298,-0.08517901,0.030839982,0.030235235,-0.033702213,-0.04294134,-0.010669068,0.03336158,0.05657422,-0.049728595,0.00077076023,0.015273409,-0.09488399,-0.002135418,-0.023955602,-0.0005539819,-0.004036948,-0.03153829,0.07551027,-0.0005734644,-0.018418247,-0.10768845,-0.054367185,0.0053304476,0.057338964,-0.013375248,-0.00040119982,-0.053417783,-0.03435956,0.0793335,0.026327867,0.024458854,0.033951387,-0.058449786,0.04731633,-0.011386203,-0.0686268,0.08779349,0.08067258,0.12635636,0.049454883,0.065905064,0.07400459,0.03681674,-0.024408497,0.0413008,-0.05613724,0.02471716,0.02055449,0.020530459,-0.03138786,0.108478405,-0.044116315,0.014398568,0.020013943,0.0055452585,-0.12297337,-0.075897105,-0.07905675,0.10156004,-0.030691374,-0.06937094,-0.007726925,-0.018212495,0.05478265,0.032340378,-0.017046256,0.047490656,-0.02112589,-0.031936705,-0.03275247,0.048621405,0.016461998,-0.085478276,-0.022703983,0.047493733,-0.0144486725,-0.014884308,0.023290604,0.025689535,0.021860652,-0.038017154,-0.051944595,0.013378461,0.030184757,-3.799049e-33,0.105033144,-0.040792968,0.035404023,-0.082704656,0.012316948,0.05328259,-0.041600678,-0.049817853,0.07301176,-0.019193003,0.02186451,0.042927872,0.04775649,0.013526736,0.06866393,-0.029627096,-0.03138404,0.038373724,-0.032190006,0.0064475895,-0.015440902,0.0894979,-0.012156151,0.14742981,-0.0017615551,-0.03968373,0.028029535,0.013290139,0.048148897,0.024732335,0.055972748,-0.027377024,-0.014774958,0.06507988,-0.050885275,0.05364784,-0.07853473,0.0004999526,0.022426099,0.07664586,-0.045567848,-0.038591858,-0.060143247,-0.011532527,0.06990419,-0.017854318,-0.087075576,0.045893293,0.025874726,-0.003187448,-0.034366682,-0.0030445661,-0.009230728,0.066489466,0.04818843,0.016524658,0.044747416,-0.025312964,0.04164481,-0.038413636,0.03311451,-0.0036974133,0.023164298,-0.039105665,-0.011799447,0.0135314595,-0.007105431,-0.024929114,0.047885187,-0.004834408,0.07731571,0.05395706,-0.041369256,0.050845683,-0.016462773,-0.009650013,-0.035502654,-0.05339513,-0.08661928,-0.045689415,-0.015473048,-0.010659432,0.10628353,-0.090419866,-0.075200215,-0.06606375,0.019407203,0.107583754,-0.011003121,0.02060786,0.0052926205,-0.013437919,-0.033462577,0.07241913,0.050014194,-4.4863203e-08,0.0025969238,-0.02854887,0.027290637,-0.062632404,-0.08351046,-0.018532326,0.056453567,0.0034244438,0.06292045,-0.07670902,-0.039273787,0.07381272,-0.01642198,0.035155624,0.07206402,-0.001631277,-0.05001038,0.010551748,-0.010599093,-0.009790607,-0.03900122,-0.026765503,-0.059888437,0.019439269,0.018841747,-0.04078568,0.032165863,0.07740021,0.03552989,0.015299111,0.06610395,0.080331,0.052875917,0.028116876,-0.026884872,0.012643792,-0.02014476,-0.011406751,-0.04643762,0.056001224,0.046819817,-0.10991625,-0.021025108,-0.0067603476,-0.026332054,-0.037355557,0.016080046,0.039677486,0.028983368,0.019252213,0.038418595,-0.008579334,-0.041104022,-0.013197501,-0.048932746,-0.04493175,-0.03928365,-0.076799996,0.0028873596,-0.029025301,-0.0041513764,0.0069597955,0.20217925,-0.0047288784 +2.3.1.286,"The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins. Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.",384,0.99999994,-0.014434198,-0.048018567,-0.0781437,0.0070252535,0.07011037,0.005429648,-0.046127606,-0.058784064,0.019036321,0.011828762,0.0571377,0.022459477,-0.08113151,0.0197876,-0.029192502,0.090530224,-0.110087626,0.031970114,-0.026521744,-0.043272838,0.13230789,0.039459623,0.036343236,-0.021403072,0.031617943,-0.032984324,0.046608903,-0.003912934,-0.03088739,-0.07493634,0.013483796,-0.052952766,0.0017887348,-0.061664753,0.04365612,0.038248826,0.022192514,-0.038639896,0.0021613159,0.048170038,0.04213569,0.01729087,-0.08284463,0.010878259,0.0025535584,-0.016700648,-0.08790982,0.014835787,0.026402261,0.0011911881,-0.047979623,-0.024757506,-0.04436611,-0.07435379,0.018918755,0.091283865,0.040989313,-0.0056578093,-0.0069344942,-0.042663157,0.02604603,-0.006246744,-0.03788632,0.00584978,0.074260525,-0.041282546,0.06671945,-0.027770871,-0.0497289,0.00977982,-0.06330943,-0.084625475,-0.07156734,0.070052005,0.098712385,-0.04573963,-0.029179173,-0.022212164,0.09368675,-0.04451766,0.05194089,-0.043577224,0.013750212,0.08379967,-0.03297938,-0.0019190671,-0.01496522,0.0087789735,0.040990017,0.04894263,-0.069020785,-0.07578403,0.038964257,-0.056285255,-0.01477681,-0.0063149547,0.0601593,0.003842805,-0.03024088,-0.051341724,-0.027590204,0.06629954,-0.003598134,-0.051617496,-0.014317597,0.04107891,-0.03046357,0.091842145,0.020761298,0.051145554,0.013827956,0.021191623,0.08913434,0.00093926233,-0.014664109,0.11083852,-0.051066846,-0.09884914,0.015456083,-0.016327035,-0.012935771,-0.008273435,0.049950235,0.11864575,-0.0066957762,0.09455461,-0.06908595,-2.806582e-34,0.062106635,-0.025369864,0.027619462,0.02042968,0.0015243532,-0.004719213,-0.09516086,-0.029090395,-0.013459224,0.023430683,-0.10488111,-0.14957352,0.065670215,0.038890645,0.050818183,-0.019216126,-0.035809837,-0.0023417308,0.06840977,0.07427021,-0.050363157,0.08796887,-0.06926067,0.041367177,0.03196561,0.0051114024,-0.015977716,0.023359954,0.03339979,-0.0057245973,0.03823427,-0.046661433,-0.05535622,0.016759468,0.053908747,-0.015462556,-0.009578007,-0.048134726,0.026750084,0.09784694,0.032698322,-0.023471715,0.036078487,-0.009705158,0.030247929,0.0029885871,0.024631562,0.026698641,-0.05306726,0.049544685,0.09196985,-0.016486948,0.07409538,-0.03158076,-0.04463506,-0.015763935,-0.1062039,-0.00486648,0.051095005,0.023365626,-0.011541588,-0.014938587,0.014912381,0.10235297,-0.012972348,0.002915596,-0.024479799,-0.13439633,-0.008337084,0.089282155,-0.07254866,-0.04185651,0.041485205,-0.025555398,-0.013043129,-0.042049147,-0.07645173,0.01759738,-0.023607936,-0.0037841266,-0.021400223,-0.039516654,-0.05149563,0.003929351,0.020338254,-0.048159238,0.008467593,-0.079208285,-0.044324026,0.030647304,0.06639663,-0.030574147,-0.07250198,0.043759946,0.1025348,-2.6210999e-33,0.04922341,-0.07960481,0.03964134,-0.08567739,-0.096692175,0.09137107,0.011259396,-0.037427615,0.049121052,-0.05287522,0.093520895,0.01967655,0.0065283785,-0.060537267,0.017683625,-0.007287992,-0.076261595,0.0386712,-0.059148252,0.0064021493,0.019779956,0.0335034,-0.052474573,0.075769186,0.052568678,0.016867384,-0.08757616,0.084015995,0.02480478,0.022048384,-0.0013598072,0.031667694,0.0036798802,0.015685365,-0.048525486,0.055526253,-0.030871278,0.05167449,-0.04804975,0.011699578,-0.08159921,0.10116687,-0.023524191,0.049531005,0.008905839,0.07993414,-0.0053523225,-0.010445443,0.00025266095,-0.030798038,0.019210966,-0.022305205,0.053457994,0.014286152,-0.004172366,0.042758502,0.024996143,0.008168374,-0.017069198,0.0067717326,-0.042508285,0.009892093,0.054666895,0.046077367,0.025680097,0.056115333,0.021059742,0.07255373,0.013083938,-0.0467821,-0.005702225,0.0011590135,0.009788469,0.042355143,0.0001602918,-0.059091795,-0.13983275,-0.00074181665,-0.022818936,-0.03682811,-0.06190842,0.0030502342,0.023490733,-0.012696731,-0.0833253,-0.12476129,-0.0060894145,0.0737086,0.04531142,0.05990782,-0.025831293,-0.008672828,-0.084412955,-0.0073592793,0.022976702,-3.9257507e-08,0.05442303,0.011707885,0.048798848,-0.071058184,-0.0022957604,-0.0020664977,0.04854522,0.053308386,0.0463639,0.01614968,-0.0660579,0.1166115,-0.023673218,-0.011891796,0.08121068,-0.0037130956,-0.017289486,0.034426402,-0.018457273,-0.03636976,-0.051799454,-0.02642198,-0.10292056,0.07739193,-0.028328948,-0.05913651,0.060520135,0.05830621,0.09044683,0.004057883,0.018756155,-0.008183767,0.02150006,-0.05905398,-0.1115952,-0.025177011,-0.011523111,-0.071311355,0.005230527,0.04227164,-0.034741536,-0.030099144,-0.045736127,-0.03190685,-0.01928815,0.0079874275,0.06415193,-0.0047476916,0.03171658,0.0038518126,0.0149507485,0.0072731925,-0.052469496,-0.06648566,-0.075450815,-0.0118991705,-0.07433727,-0.044003744,0.02275801,-0.020993916,0.011471249,0.035784025,0.17805167,-0.087583326 +2.3.1.287,"This mycobacterial polyketide enzyme produces the hepta- and octa-methylated fatty acids known as phthioceranic acids, and presumably their hydroxylated versions. Formation of hepta- and octamethylated products depends on whether the enzyme incorporates seven or eight methylmalonyl-CoA extender units, respectively. Formation of hydroxylated products may result from the enzyme skipping the dehydratase (DH) and enoylreductase (ER) domains during the first cycle of condensation [2].",384,0.99999994,-0.04883047,-0.05545221,-0.057316363,-0.03584136,-0.011139849,-0.020139221,-0.031711716,0.05486861,-0.012544545,-0.03847966,0.004927617,-0.101946436,0.018153088,-0.025282288,-0.01415569,0.01238504,-0.011242733,-0.035448227,-0.023732893,-0.018459339,0.14678857,0.05718079,-0.04000291,-0.058119416,0.050973855,0.035580005,0.11372746,-0.043595254,-0.02257581,-0.09170579,0.023125352,-0.05812612,0.017133325,-0.07461727,0.124666795,0.098183945,-0.03228741,-0.06262722,0.072970055,-0.008415183,0.14710751,-0.058721233,0.011287842,-0.06520267,-0.012946293,0.017571734,-0.042630635,0.0440786,-0.016742647,-0.027022038,-0.052830033,-0.076032646,-0.045769412,0.056466524,0.019802263,-0.052055754,-0.034428373,-0.001996718,-0.039229147,0.011561982,0.04635426,0.01687288,0.0209632,0.0093722455,-0.0019590496,-0.070688725,-0.0049737324,-0.032524504,0.0046389285,-0.020440064,-0.066576205,0.052336313,-0.008607585,0.08383294,0.028950289,-0.0147565175,0.008780481,-0.030820437,0.033834226,-0.018570345,-0.03175018,-0.022049593,0.0043644346,0.048760757,0.018705359,-0.023351341,0.06362462,0.020674737,0.006019419,0.08542938,0.015380839,-0.032782774,-0.018304355,-0.06842154,-0.0570952,-0.046021413,0.05643023,0.018825345,0.033567376,-0.04614289,-0.025700545,-0.037821073,-0.045076475,-0.046363954,-0.055241372,0.03596115,-0.045735456,0.05954076,0.093357004,0.069872044,-0.08363288,0.0035637056,0.0028366833,-0.06270867,-0.022600396,0.102604546,0.02946327,-0.023673194,-0.075423144,-0.028807875,-0.047790077,-0.05982471,0.113971494,0.028774068,-0.07652236,-0.0181116,-0.09961053,3.810774e-33,0.031762052,-0.06936501,0.058767278,-0.037421163,0.006069472,-0.0404468,-0.11265211,-0.003124893,0.0053233868,-0.09336377,-0.0377997,-0.03423993,0.0049768104,0.107288234,-0.045835614,-0.013654048,0.005055477,0.05278744,0.06051869,0.01114121,-0.047565438,0.0030636215,0.024581023,0.014946236,-0.02356344,0.02987924,0.00695363,-0.008532906,0.01941593,0.02492947,-0.0072962106,-0.07533842,-0.037882395,-0.003105369,0.05122443,0.0404869,-0.044422254,-0.048860345,0.012252864,0.07395739,0.058904164,-0.04889907,0.04160962,-0.04151066,0.010015334,0.035179064,-0.017893584,0.038640395,0.023030762,-0.024697065,0.031550333,0.005456202,0.04420575,-0.034147907,-0.041753996,-0.025441647,-0.03001876,0.0013214428,0.0038298618,0.03326653,0.030316077,0.10012389,-0.051782046,0.11047412,-0.0963603,-0.08282451,-0.047709983,-0.0073966165,0.043439835,0.011157489,-0.016541436,-0.0500583,0.045603164,0.013037436,0.0849483,-0.03596461,-0.052469887,-0.004279185,-0.011326564,-0.0109926555,0.14031151,0.0049863793,-0.03516444,-0.09555884,-0.06420504,0.024601389,-0.057285286,-0.04916927,-0.011879909,0.04590067,-0.018191608,-0.09451166,0.0059393905,0.023796352,0.001710374,-7.0648695e-33,0.08446155,-0.094123125,0.05761262,-0.111680634,0.029124677,0.013698756,0.10388517,0.043530915,0.046423048,-0.032879878,0.055807333,0.0040820627,-0.011323258,-0.020693893,-0.0027617032,0.033167575,0.0036577284,0.0551386,0.04103596,-0.062782474,0.0016560446,0.037052616,0.017316755,0.013658692,0.037872005,0.0064964658,-0.07044608,0.13774265,0.06786954,0.079502515,0.014371913,-0.01757679,-0.01721369,-0.032843843,-0.06519153,0.012384299,-0.12039363,-0.06086064,0.07853706,0.016074546,-0.014514848,-0.045076758,0.017693834,-0.0016853143,0.029496882,-0.006442989,-0.06010914,0.006064967,0.022958452,-0.05782324,0.013174661,0.035565853,0.0038206659,0.038230494,0.02527808,0.06800924,0.016298622,0.035776608,-0.023276862,-0.068031065,-0.08429912,-0.040824596,0.08314693,-0.03987684,0.014808891,0.078912206,0.087430075,0.0024343773,0.045149416,-0.017657131,0.036564413,-0.033075456,-0.070273824,0.058504313,-0.011426095,-0.040946577,-0.055772062,0.039274417,-0.020625835,-0.02536228,-0.07409313,-0.023609446,-0.01656089,-0.10458686,0.014365252,-0.093318254,0.05220084,0.039068818,0.0020702044,0.1042561,0.011161528,0.06277978,-0.04800419,0.09926891,0.053009525,-4.553821e-08,0.026971057,-0.13926627,0.054867074,0.021738872,0.02192703,-0.013842133,-0.022176659,-0.069841824,0.05416042,-0.07515507,-0.0050696707,0.042251352,0.035205346,-0.006048359,0.0382348,-0.025525747,-0.042901415,-0.023365874,0.0005934071,-0.08933708,-0.10276067,-0.02900063,-0.010140107,-0.0047022197,-0.017321466,0.0034116162,0.035802186,0.04861,-0.0022189775,0.020620676,0.01607708,0.09722078,-0.012534888,-0.09218832,-0.030572176,0.03255551,-0.047938604,-0.017361078,-0.0008359246,0.0459362,0.05973724,0.041739307,-0.03989226,0.040432308,0.07639673,0.04692055,-0.06122793,0.028793022,-0.008831698,-0.009866318,-0.0046218624,0.0646053,-0.039840117,0.016868938,-0.024025341,0.06345644,-0.054247007,-0.028705748,-0.069397874,-0.019487925,0.037566617,0.010493876,0.15908748,-0.02754455 +2.4.1.363,"The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the free C20(S)-OH group of dammarane derivative substrates, including protopanaxatriol, dammarenediol II, (20S)-ginsenoside Rh2, and (20S)-ginsenoside Rg3. It does not act on the 20R epimer of protopanaxadiol, or on ginsenosides that are glucosylated at the C-6 position, such as ginsenoside Rh1 or ginsenoside Rg2.",384,1.0,-0.042866684,-0.05454762,-0.08549734,-0.054076243,0.078297526,0.051360134,-0.08462323,0.0907302,0.07779381,0.033305362,0.00089893764,0.03437059,-0.06368724,0.05131832,-0.059086885,-0.011665928,-0.080215916,0.055993807,-0.025256487,-0.06306632,0.062242966,-0.050567962,0.06467635,0.044289276,0.10577074,0.0056499033,0.011106902,-0.031795416,0.018231718,0.047557905,-0.0130818365,0.023691103,0.00644714,-0.048639532,-0.0796068,0.038180865,-0.043001115,-0.089533694,0.09041311,-0.003654039,0.09138942,0.023007747,-0.015802557,-0.02201306,0.018879822,-0.027654244,-0.02499493,0.05122905,0.0090325335,0.061954577,0.06672261,-0.061207965,0.019458126,-0.034746118,-0.004001931,0.0057109534,-0.019783266,-0.0053464323,0.037537385,0.11890625,0.048931945,-0.0047203344,-0.10079634,0.06543405,-0.07621589,-0.038095254,-0.012097632,0.095092475,-0.0141735915,-0.0068038525,-0.03474763,-0.037809625,0.007702763,0.047743887,0.036099546,-0.008859711,-0.006625934,0.063157156,0.017338127,-0.058098912,0.029869985,0.00024525492,0.029356722,0.09276441,-0.024541683,0.04289019,0.043241087,0.13424163,0.07533247,-0.047319897,0.016780138,-0.003138395,-0.091350205,0.032797813,-0.02876074,0.032151442,0.0369532,-0.010646366,-0.010307337,-0.026894158,0.015274658,0.016249275,-0.007102056,-0.080633044,-0.035313837,0.07288086,-0.09960839,0.028869685,0.014328211,0.036864184,0.046112843,0.03544391,0.039780457,0.011002711,-0.07980373,0.02972971,-0.049490724,-0.07388632,-0.0052443235,-0.04787299,-0.0021407746,-0.07225114,0.033750035,-0.01712248,-0.067303084,0.009881147,0.034043975,5.603851e-33,-0.031398557,-0.049493033,0.008451456,-0.033500366,-0.0017104391,0.07253443,-0.034656446,-0.025409166,-0.05077385,0.003249076,-0.09893955,-0.038012963,-0.036103856,-0.005025642,-0.003582266,0.044828027,-0.010502034,-0.032082003,-0.010879123,-0.008019281,0.015864529,0.10497913,-0.15643711,0.041844755,-0.030328404,0.026702685,0.008860866,-0.05549089,0.025252646,-0.025750924,-0.020412287,-0.02697291,-0.0060632485,0.031584363,-0.007506737,0.044380333,-0.048650064,-0.06205336,0.0126691945,0.006419306,0.036060687,0.02340418,-0.0053771595,0.011289512,-0.0133619215,-0.11006527,-0.057186347,0.04635575,-0.004458087,0.11398292,-0.008485988,0.089614615,0.041623533,0.051753912,-0.02493739,0.031701334,-0.03283328,-0.012280015,0.06335536,-0.02177332,0.0014218255,-0.011505644,0.0071000936,0.010777981,0.02302631,0.12767126,-0.105068795,-0.020501714,-0.018812127,0.10470867,-0.041989,-0.034086697,-0.07186909,0.06301925,0.02919569,-0.03801564,0.024219094,0.07873171,-0.027267128,0.023278683,-0.010942273,0.03317517,-0.019212158,0.04670071,-0.08695852,-0.023654688,-0.043216143,0.0038749815,-0.03188158,0.04713051,0.084342726,-0.031278946,-0.05152831,0.07597448,0.0048593096,-6.268071e-33,0.08581172,-0.08234061,0.082097046,-0.0073461984,-0.020054359,0.01182044,0.021514332,-0.04569187,-0.018161414,-0.006710397,0.08664069,0.06858972,0.0039338837,0.033892628,-0.031703968,0.019251145,-0.0135683585,0.09173025,-0.10672786,0.04860097,-0.010383029,0.0995728,-0.0066828695,0.016967881,-0.012563065,-0.021694606,0.0144020235,-0.031739935,-0.0114258705,0.03546976,0.05906364,-0.023299383,-0.08550009,-0.0076819323,0.0128824,0.033380568,0.07114792,-0.042779643,-0.07628771,0.016737191,-0.030913066,0.088445775,0.028069755,0.045418493,0.08446356,0.046542034,-0.114266515,0.030032072,-0.07257454,-0.007983692,-0.085302435,0.07659004,0.013462435,0.023079611,0.054964397,-0.06595072,0.036448527,-0.09573129,-0.04863721,-0.06032536,-0.017527785,-0.07408633,-0.008792578,0.00023997421,0.06382598,-0.024522403,-0.086620755,0.11965215,0.018619776,0.00961503,0.0490755,-0.026345639,0.03624168,0.021334266,-0.008634972,0.0007420163,-0.04163914,-0.06793896,-0.014521916,-0.043282136,0.061858416,0.056484036,0.021513445,-0.010879196,-0.075678915,-0.0394663,-0.016587008,0.060526177,0.027971527,0.03324753,-0.0026547238,0.0021784173,-0.042592995,0.023225943,0.1694595,-4.4641055e-08,-0.04910808,-0.015558409,0.016970139,-0.047723833,-0.073646106,-0.020081118,-0.08896875,0.020563394,-0.0039789802,-0.0017350724,0.0040265713,0.049450114,-0.008486259,0.010871618,-0.02813359,0.008907009,0.05205316,0.039286643,-0.020810552,0.04136388,-0.074568495,0.0020311463,-0.026159255,0.0052886456,-0.013418616,-0.09222667,0.0020276427,0.09480223,0.008037434,-0.008602762,0.0016870031,0.029539395,-0.0035774847,0.03992831,-0.04840487,0.08110319,-0.041165538,0.06864921,-0.038172938,-0.019270979,0.0038062448,-0.14619273,-0.030598026,0.01968649,-0.03610092,-0.034535337,0.081913084,-0.017592337,-0.00015053093,-0.012710765,-0.0058696764,-0.007390889,0.014120203,-0.11018449,-0.039601274,-0.043725006,-0.06122225,0.03604163,0.0327279,-0.112960905,-0.06022647,-0.013709711,0.104956284,0.0023167017 +2.4.1.364,"The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the free C-3-OH group of (20S)-protopanaxadiol and ginsenoside C-K.",384,1.0,-0.045556236,-0.032342695,-0.1049509,-0.023647971,0.051803563,0.06226263,-0.063839525,0.059524372,0.09317486,0.07462461,0.032116055,0.01274145,-0.051381413,0.022029376,-0.049151704,-0.020846462,-0.06835499,0.090703614,-0.06980372,-0.04543478,0.038130112,-0.04531625,0.044524703,0.037120335,0.117229454,0.010060537,-0.00021593724,-0.07451953,2.352738e-05,0.07238778,-0.04992334,0.03023674,0.059561793,-0.05267213,-0.039217148,-0.015876366,-0.07191697,-0.09204286,0.064917214,-0.008990563,0.08985764,0.036639303,0.011964648,-0.019582124,-0.0006013155,-0.021729795,-0.037026074,0.03865786,0.045427233,0.039758377,0.018756758,-0.05229166,-0.019887986,-0.025416827,-0.031404547,0.012107719,-0.022451077,-0.036881477,0.070125006,0.12710431,0.055899587,-0.033884745,-0.08819713,0.06821809,-0.026494026,-0.06432153,0.003277002,0.08139103,-0.004474166,-0.009358586,-0.053469297,-0.0779734,0.06259458,0.013947334,0.08126476,0.00073606,0.00052616396,0.06725335,0.022926884,-0.05622073,0.06933356,0.03754165,0.005729576,0.11508299,-0.034691263,0.036190137,0.009828252,0.112239264,0.054699898,-0.059887853,-0.03864218,-0.010988862,-0.07868125,0.018016296,0.002739905,0.046941627,0.06145169,0.02152807,-0.036176894,-0.029553741,0.050842676,0.046849128,0.06003286,-0.08641112,-0.059533387,0.057001654,-0.06982725,0.02925752,0.03635834,0.06744323,0.025628299,0.050979566,-0.0062728114,-0.038210403,-0.06269845,0.0522965,0.006455384,-0.06198584,-0.008955669,-0.005421004,-0.00086786883,-0.08111511,0.035634015,-0.00055824016,-0.08765574,0.020021964,0.039159443,-1.4556139e-34,-0.03516764,0.04323731,0.028933054,-0.0072413073,0.0065311324,-0.023609633,-0.045678895,-0.038526636,-0.074523345,0.016134534,-0.12818532,-0.017120223,-0.017381115,-0.0024214967,-0.054137137,0.056766164,-0.012442773,-0.06798546,0.011231515,-0.014768096,0.064282864,0.11024544,-0.13433304,0.09574313,0.005006331,-0.03105972,-0.009587673,-0.010408779,-0.008499911,-0.042523723,-0.013564366,0.013622149,-0.016939867,0.027306668,0.022735652,0.014712188,-0.039104167,-0.09868685,-0.008779937,0.026458688,-0.022649689,0.0042834477,0.020050494,0.013861062,0.008688541,-0.047502823,-0.09132045,0.038033083,-0.001018235,0.14176477,-0.009239484,0.07319527,0.030885428,0.06409873,-0.06272172,0.05728142,-0.002063545,-0.0053325547,0.07532099,-0.037199777,-0.045742217,-0.027937725,-0.04338802,0.04349434,0.0041675307,0.10055238,-0.11709841,0.01298248,0.009835269,0.0813528,-0.06608839,-0.0042755045,-0.10756115,0.05170924,0.048020545,-0.019560875,-0.003106964,0.047720958,-0.040314037,0.012117948,0.041827865,0.012875854,-0.027448414,0.025052045,-0.07976491,-0.0463652,-0.07491811,0.031404097,-0.026707746,-0.01847719,0.04823349,-0.021445053,-0.028887788,0.07120618,-0.0083534485,-1.5388612e-33,0.08150865,-0.106563866,0.048455305,-0.0025325792,-0.004482261,0.022778068,-0.0014775947,-0.06583235,-0.027915636,0.006567168,0.0840084,0.045065235,0.048566226,0.030166076,-0.02570799,0.026332537,-0.01217925,0.092186145,-0.09423118,0.05254896,-0.01002561,0.055727743,0.0011852654,-0.018763779,-0.014393622,-0.006551525,0.026183544,-0.018545114,-0.02913893,0.08224316,0.060523048,-0.029414156,-0.047384452,0.028829908,0.045012567,0.04386984,0.043195717,-0.043119717,-0.06126569,0.009038399,-0.05112116,0.06770275,0.06658806,0.033053312,0.07406261,0.025598036,-0.095842496,0.020372473,-0.06487134,0.016648341,-0.025689851,0.062605426,0.032187827,-0.0012579025,0.059131127,-0.036426138,0.06276632,-0.057768326,-0.04804556,-0.048338797,-0.054073397,-0.06065532,0.005356426,0.0010547624,0.0921699,-0.0058983606,-0.10233342,0.11382761,0.0114576975,0.00858625,0.0174884,0.013404683,0.04947157,0.0045387857,-0.020788074,-0.032359537,-0.006197146,-0.041922674,-0.04256066,-0.035214618,0.07922904,-0.0010678207,0.059961632,0.0134959975,-0.10328341,-0.028458571,-0.0013983161,0.06831785,0.019312344,0.048695024,-0.028045045,0.030030582,-0.06834321,0.009011672,0.13776444,-3.027428e-08,-0.041738115,0.01808249,-0.0016123566,-0.029618135,-0.016023133,0.0059140106,-0.12444034,-0.0074923304,0.026224457,0.01810862,-0.015351065,0.053359646,-0.045410797,0.017565472,-0.06091166,-0.0030505178,0.0028383308,0.01418491,0.012907345,0.055740897,-0.056780383,0.023001237,-0.025020571,0.0348314,0.019350978,-0.102713734,-0.0025103672,0.08327066,-0.0012075511,0.0026426702,-0.01905061,0.01132832,-0.03793953,0.028475963,-0.10337779,0.04904974,-0.041466802,0.019446857,-0.02226348,-0.01549524,0.0455152,-0.073528424,-0.030526632,2.6715472e-05,-0.06375506,-0.023940844,0.044823248,0.0019154154,-0.012476855,0.0060076294,-0.039266508,-0.006594753,-0.038286388,-0.07555828,-0.04601367,-0.06075521,-0.023542158,0.030329878,0.05877776,-0.11310746,-0.06562837,-0.041177653,0.108104795,0.033236057 +2.4.1.365,"The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the 2'' position of the glucose moiety in the protopanaxadiol-type ginsenoside-3-O-glucosides (20S)-ginsenoside Rh2 and ginsenoside F2.",384,1.0,-0.0251779,-0.027892763,-0.11210223,-0.0089716315,0.05599019,0.018616058,-0.024982728,0.08566368,0.091577634,0.06549367,-0.015067754,0.06551318,-0.06583973,0.017786765,-0.039599124,-0.02765184,-0.060729142,0.053455755,-0.029660767,-0.030474657,0.11967065,-0.016985923,0.058392886,0.004526249,0.123718604,-0.013757151,0.012395567,-0.06646038,-0.0143199405,0.05040183,-0.03487061,0.020459136,0.035016425,-0.037619755,-0.037018515,0.02601755,-0.021860002,-0.093151905,0.061390977,-0.058472957,0.08323283,0.043067735,0.048630923,-0.010945598,0.017331867,-0.030620327,-0.038982246,0.045286346,0.05805758,0.065988176,-0.004708665,-0.05734204,-0.014838093,-0.01713321,0.012559556,0.029547557,-0.008116749,-0.012304282,0.037418384,0.09446446,0.05067634,0.0037942422,-0.10386891,0.057748985,-0.037391845,-0.06819145,0.012579143,0.034397837,-0.04804017,0.0002616345,-0.03523841,-0.029983446,0.02211118,-0.021683538,0.08597794,-0.015937977,-0.06018225,0.07959536,-0.0013718317,-0.03374352,0.07435618,0.01588543,0.063756585,0.119045444,-0.059589043,0.01216481,0.044220142,0.104139805,0.05276285,-0.06442681,-0.044289935,-0.025132356,-0.06593362,0.045410562,0.014131259,0.02144378,0.034755163,-0.0008442595,-0.0035017794,-0.02612416,0.027437182,0.020470643,0.07064902,-0.07551609,-0.051766094,0.088832475,-0.08249079,0.05381778,0.050274216,0.036278203,0.04800941,0.067614734,0.016041862,-0.026256151,-0.08481271,0.05348124,-0.02106095,-0.06393655,-0.026301833,0.0045738155,-0.0120643405,-0.056346104,0.029704437,-0.03175286,-0.06654124,0.047825787,0.02706174,2.1004427e-33,-0.010676118,-0.0062130443,0.021914402,-0.004725921,-0.008988955,0.02561618,-0.02837864,-0.03843882,-0.04033318,0.049611103,-0.13523185,-0.021716505,-0.022966735,-0.0061232527,-0.03455302,0.040595695,0.003545671,-0.054029975,0.03550038,0.011222373,0.04903369,0.13836935,-0.0996424,0.078605935,0.02422963,0.015377573,0.0027008238,-0.020375893,0.0002471276,-0.028190667,0.022612607,-0.010915181,-0.009836008,0.00876796,0.044954095,0.038128726,-0.052451998,-0.056479584,0.011258686,-0.012602924,0.018840026,0.02137725,0.035067886,-0.021493021,0.008201251,-0.041789018,-0.05356997,0.04377857,0.017053632,0.16913655,-0.028195634,0.061380453,0.03400627,0.104886934,-0.036841862,0.017416269,0.010948614,-0.008672039,0.031827103,-0.0148299895,-0.023813773,-0.036549047,-0.003304113,0.0076242643,0.004115366,0.103842035,-0.10889145,-0.030192299,-0.020838192,0.107360154,-0.058596328,-0.043776177,-0.082196966,0.040341374,0.026248183,-0.051721,0.013758865,0.04987167,-0.028457673,0.01683242,0.041834358,0.021406151,-0.05068082,-0.0103404,-0.12581497,-0.031465527,-0.071503595,-0.015512402,-0.03523807,0.01709742,0.03879679,0.008329213,-0.052277476,0.05060194,0.019307446,-3.496664e-33,0.043955218,-0.11407347,0.07999322,-0.017131751,-0.031236783,0.006656861,0.008309855,-0.097511135,-0.023434713,0.02603995,0.050564792,0.065246634,0.014743032,0.019669442,-0.043436725,0.028247762,-0.03111542,0.06989944,-0.075201325,0.023662696,-0.02477106,0.10486202,0.009831413,-0.015843118,0.026816402,-0.009279236,0.057981215,-0.01093182,-0.0079037035,0.023834612,0.047638442,-0.0148623595,-0.06286469,0.041520603,0.024271134,0.024938408,0.04029537,-0.058315855,-0.08030846,-0.003992458,-0.02547384,0.1114437,0.081166476,0.03483202,0.117843956,-0.0010019758,-0.12327079,0.0485721,-0.10214729,-0.022406908,-0.08087555,0.063405186,-0.007141594,-0.006270207,0.0514374,-0.03350241,0.019434664,-0.047407717,-0.044944495,-0.04034469,-0.025635347,-0.079341255,0.00016637129,0.009883642,0.061919015,-0.030030895,-0.055059668,0.072176516,0.015628114,0.07653192,0.0018223609,-0.031143034,0.036321647,0.038869385,-0.04251771,-0.014343594,-0.036164843,-0.039940078,-0.043573953,-0.060692124,0.06806412,0.02635396,0.049059622,-0.016374711,-0.07265954,-0.053685505,-0.011635081,0.07150498,0.036375772,0.046505716,-0.0468413,0.031823486,-0.048171345,-0.037945632,0.12873906,-3.5764042e-08,-0.033430364,-0.008914904,-0.011752214,0.0046610585,-0.08357422,-0.008132368,-0.09765307,0.024275498,0.0003363262,0.008699793,-0.048840538,0.09585042,-0.046189718,-0.032312524,-0.033059042,0.018637044,0.013701102,0.03151366,-0.009016381,0.08671108,-0.0683649,0.0017682452,-0.073368974,0.04676547,-0.014342566,-0.114164695,-0.013659539,0.04975953,0.008914482,0.030552179,0.012210157,0.03957567,0.010177731,-0.018462338,-0.10179166,0.014221358,-0.034555335,0.046078645,-0.022518137,-0.043875985,0.028525623,-0.08210654,-0.015143573,0.008515753,-0.0567481,-0.0042826775,0.07417269,-0.018873204,-0.010237133,0.013394329,-0.044715825,-0.019677224,-0.040051058,-0.06773809,-0.046505578,-0.0752298,-0.0421934,0.045319702,0.045422785,-0.101256154,-0.07731803,-0.0039199986,0.102700375,-0.005433919 +2.4.1.366,"The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of ginsenoside F1. The enzyme also glucosylates the C-20 position of protopanaxatriol, which forms ginsenoside F1 (cf. EC 2.4.1.363, ginsenoside 20-O-glucosyltransferase). However, unlike EC 2.4.1.367, ginsenoside 6-O-glucosyltransferase, it is not able to glucosylate the C-6 position of protopanaxatriol when position C-20 is not glucosylated.",384,1.0,-0.043990485,-0.025734078,-0.08793547,-0.040337756,0.016169019,0.05834784,-0.10916922,0.12249804,0.104442716,0.033326987,0.019111479,0.068074726,-0.07330866,0.030286876,-0.06771894,-0.034359425,-0.08808174,0.07039179,-0.06313288,-0.05213595,0.05484738,-0.040133376,0.03456327,-0.00083327555,0.11811864,-0.072881095,-0.011613127,-0.04117516,0.0034282992,0.038432986,-0.050756067,0.056913786,0.008846936,-0.035222877,0.008803181,-0.014365139,-0.055199966,-0.08181527,0.117162175,-0.014802282,0.042824037,0.0055520395,0.023682646,-0.05482583,0.02641203,-0.01795157,-0.014808615,0.06739444,0.04681965,0.040628776,0.021914877,-0.06049579,-0.020124145,-0.018688476,-0.0022097991,0.00448776,-0.013023013,-0.05000224,0.10896822,0.08744198,0.05994341,0.0041068867,-0.089092374,0.063526474,-0.031226926,-0.03492447,0.03505086,0.037436705,-0.021072436,-0.015834248,-0.024442643,-0.054371323,0.039275963,0.0314663,0.05052399,0.015042079,-0.029556718,0.032839533,0.02433069,-0.047262214,0.08620422,0.065915756,0.022389937,0.072777316,-0.05243707,0.012307765,-0.00059322506,0.10920006,0.026006976,-0.024914889,-0.02392394,-0.029435612,-0.07674838,0.02246708,-0.018523011,0.030843465,0.059157368,0.024679761,0.00835155,-0.074912086,0.03366877,0.02411409,0.05038438,-0.05895815,-0.0029711388,0.065404035,-0.076185316,0.075659506,0.04538133,0.0108135985,0.02097897,0.048406158,-0.0124147665,-0.030953487,-0.08083618,0.053296756,-0.024478946,-0.052538823,0.0032650738,-0.009379614,0.018327061,-0.058973055,0.024827614,0.03454463,-0.05645633,0.026738724,0.035940822,4.4146576e-33,-0.023493681,-0.0118123945,0.04857398,0.017911391,-0.012200014,0.037948705,-0.018587064,-0.071220666,-0.06376475,-0.010637606,-0.12356647,-0.05000039,-0.031942055,-0.017822072,0.006415621,0.0530148,-0.02144887,-0.05632301,-0.043121565,0.006720687,0.05785049,0.10343682,-0.10380716,0.015285347,0.037127245,0.032739785,-0.036200367,0.010825639,-0.04232678,-0.025292633,-0.06542484,0.014011885,-0.0013168757,0.03383009,0.087806076,0.029461537,-0.030517591,-0.077445626,0.015686695,0.017265126,0.033080965,0.040567916,-0.013374122,-0.0011651963,0.04012605,-0.07829619,-0.09198215,0.026039932,-0.023529755,0.15202384,-0.02952172,0.10112264,0.04402905,0.052498613,-0.016770786,-0.01312651,-0.013999551,-0.023739796,0.035412434,0.012395613,0.0077170916,0.0036745819,-0.026365668,0.010645572,-0.008867828,0.08632831,-0.123215035,-0.012192052,-0.0326228,0.11585631,-0.046688583,-0.046943568,-0.06674631,0.035067104,0.052677702,-0.04672301,0.03324707,0.08840109,-0.0341333,-0.026875235,0.04339127,0.03242433,-0.033216476,0.033772983,-0.08175716,-0.008411877,-0.050863113,0.0037811853,0.014867752,0.052362166,0.049279936,-0.05591457,-0.067782275,0.096006714,-0.025711503,-5.028622e-33,0.04692609,-0.059909355,0.06601827,-0.044127464,-0.07019055,0.044150516,0.036297213,-0.082134604,-0.05773813,0.0038394537,0.07247307,0.0643459,0.0015836256,0.031757206,-0.06100355,0.0076951026,-0.041263945,0.060358785,-0.08093138,0.10261409,-0.022917595,0.055053238,-0.03559348,0.011684847,0.02491115,-0.0069876397,0.01724914,-0.03808618,-0.018324157,0.020885684,0.043579817,0.0070667104,-0.05924614,0.017457245,0.024949249,-0.009937608,0.029454742,-0.032277066,-0.039927393,0.014025696,-0.037353165,0.09683463,0.039957643,0.029889788,0.08927173,0.040469453,-0.065259285,0.0016375856,-0.07693992,0.018549379,-0.033021312,0.052167706,0.01920552,0.043674257,0.018118965,-0.04185773,0.09609775,-0.04944368,-0.043365143,-0.044897377,-0.03444122,-0.050416175,0.033750232,-0.03299346,0.11149638,-0.0033304791,-0.083619304,0.15420152,-0.002886996,0.024519634,0.0500557,-0.038541816,0.046451345,-0.002781406,-0.02669425,0.005871648,-0.006034555,-0.040809296,0.0064882264,-0.033939417,0.0056191427,0.033574104,0.048900362,0.029985407,-0.07129772,-0.008695264,0.013042385,0.06039618,0.022973869,0.08315676,-0.022279099,-0.0005473168,-0.049639754,-0.0035208964,0.13238549,-3.897314e-08,-0.03441387,-0.010427275,-0.0049449704,-0.030501321,-0.04834968,-0.026650237,-0.0713643,-0.018570764,0.011311418,0.02168864,-0.03924507,0.06564748,-0.020454833,-0.055012893,-0.06811943,0.021155292,-0.009576537,0.028612461,0.00824666,0.07905879,-0.08049277,0.016674448,-0.036027905,0.053997982,0.009851702,-0.117418386,0.02133196,0.13561952,0.031840563,-0.021874016,-0.028130073,0.014580022,-0.04934202,-0.015306259,-0.077863574,0.058322914,-0.035996094,0.03422954,-0.0547837,-0.0072121364,-0.009077717,-0.11012077,-0.024894612,0.0033556093,-0.017431453,-0.019166987,0.053859077,-0.029934606,-0.017250998,0.027850019,-0.047223,-0.04144517,-0.023765545,-0.08612102,-0.05817005,-0.05394719,-0.025924722,0.020890811,0.043472122,-0.0944806,-0.072112665,-0.009453016,0.1150834,0.028868072 +2.4.1.367,"The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of protopanaxatriol and ginsenoside F1. ",384,0.99999994,-0.04103784,-0.042635493,-0.08508322,-0.039554678,0.018255413,0.10060679,-0.09388037,0.09740119,0.06966249,0.061929595,0.0015031509,0.015126763,-0.085703634,0.0133024305,-0.08633689,-0.03779235,-0.084964074,0.041501865,-0.052023605,-0.034682892,0.031183204,-0.017284723,0.03442505,0.032223005,0.12791312,-0.019017342,-0.008371501,-0.052458335,-0.002761267,0.050550144,-0.0742801,0.072585255,0.05371875,-0.021567473,-0.014944095,0.0138385445,-0.048936196,-0.092866145,0.103439376,-0.022692423,0.07027664,0.023172732,0.019580385,-0.048674442,0.020322954,-0.005291073,-0.028591087,0.062148564,0.07946985,0.046422243,0.01682392,-0.05881496,-0.010146653,-0.00984817,-0.021547616,-0.00055820466,0.0004467488,-0.06680844,0.10373168,0.1163679,0.061261166,0.0059727137,-0.08850641,0.07426431,-0.006460064,-0.049207713,-0.012383442,0.06594754,-0.011241261,-0.0014359404,-0.04089688,-0.047668945,0.052216128,0.023154123,0.040804107,0.0052839085,-0.02629032,0.004907858,0.0015729535,-0.053464144,0.059473976,0.08584894,0.0065723946,0.10927604,-0.030587211,0.040112723,0.009960905,0.10541398,0.05616434,-0.05224179,-0.01775195,0.006628638,-0.0704862,0.0046408554,-0.044818815,0.043969315,0.03677221,-0.01436147,0.014524258,-0.04740535,0.05897828,-0.0027751713,0.056696236,-0.077731535,-0.015615959,0.057144012,-0.10158572,0.062122423,0.044097226,0.03479401,0.0096933395,0.028535197,-0.012113634,-0.04138765,-0.061532278,0.049128555,-0.0049040923,-0.041903988,0.008028791,-0.013079855,0.022387134,-0.056926437,0.04935082,0.011279266,-0.07777422,-0.0009311488,0.014928871,1.7360275e-33,-0.016859455,-0.008629568,0.07365884,0.019072324,0.0039707487,0.018242555,-0.017978355,-0.053388048,-0.06843606,-0.004429436,-0.118759505,-0.015392104,-0.024264835,-0.025883636,0.0014405005,0.039580286,-0.014060204,-0.061423674,-0.017653149,-0.0031167017,0.050442398,0.109169915,-0.12240411,0.04410456,0.009715208,0.020268412,-0.00489954,-0.0075387377,-0.046101462,-0.034494203,-0.039659355,0.019834157,0.0038121773,0.026170926,0.06778528,0.024930272,-0.019539058,-0.07803122,-0.016157005,0.030089803,0.030632408,0.0122695295,-0.0028375143,0.0075384025,0.023143478,-0.06562262,-0.10435606,0.054940995,0.0019935297,0.14345732,-0.010928462,0.062192462,0.07465177,0.052519318,-0.04270878,0.039587673,-0.014231811,5.7278303e-05,0.03286768,-0.00016369336,-0.016378306,-0.024939816,-0.041759264,0.047124606,0.003101726,0.07581616,-0.12678197,-0.008415414,-0.01345612,0.1061138,-0.072261885,-0.0506507,-0.07132664,0.043387424,0.032008268,-0.012013794,0.00012617894,0.089884974,-0.06024833,-0.0057968674,0.024924373,0.014133983,-0.03871765,0.043063384,-0.10591893,-0.014395215,-0.05287018,0.041317146,0.0016881439,0.003801209,0.081501044,-0.040116195,-0.059348453,0.06780518,-0.031506184,-2.9282137e-33,0.05436009,-0.07083555,0.078493014,-0.0031343692,-0.06398546,0.042907037,0.021209309,-0.097285576,-0.07331513,-0.001632782,0.068923354,0.055708278,0.024489248,0.01388348,-0.057572346,0.04565499,0.0019980879,0.06880475,-0.07351126,0.09486511,-0.04972939,0.041832812,-0.046945237,-0.03085415,0.0067022243,0.0026252575,0.053427838,-0.0376949,-0.021578066,0.0232188,0.042185307,-0.011204839,-0.062735766,0.009995721,0.03261313,0.009587166,0.03061853,-0.054988522,-0.037175804,0.023504838,-0.040607177,0.092853904,0.05393756,0.048689596,0.090630196,0.0045248917,-0.08493868,0.025428878,-0.095379725,0.050509382,-0.026603408,0.024466466,0.02521668,0.0004171065,0.023391733,-0.057652988,0.061723158,-0.064319864,-0.034175556,-0.025886098,-0.016738836,-0.030376907,0.025198117,0.0047770175,0.07736443,-0.023790542,-0.09139163,0.12800218,-0.014340702,-0.008221052,0.051455975,0.0033291753,0.06545649,0.004420782,-0.0518777,-0.0038693033,0.0032933848,-0.059871927,-0.0042430162,0.013732314,0.026436212,0.040493105,0.038120836,0.030550402,-0.101017825,0.0034333356,0.031730376,0.08357962,0.043901324,0.05590731,-0.017322052,0.016287697,-0.075833656,0.008519977,0.13119197,-2.7486767e-08,-0.02127411,-0.03155324,0.0030712439,-0.053449355,-0.038400598,-0.0057105026,-0.057911932,-0.011398395,0.00845475,0.010310986,-0.028792046,0.052593265,-0.021594819,-0.031486843,-0.07434997,-0.0005622131,0.012544928,0.02247394,-0.003196362,0.0890616,-0.06818085,0.00010123234,-0.04107479,0.032510392,0.014895239,-0.111249655,-0.0144160045,0.122573264,0.028711332,0.0074747973,-0.03615984,0.018736782,-0.036052886,-0.0483495,-0.07972029,0.07932286,-0.022135762,0.0031796047,-0.06411134,-0.022955725,0.033574548,-0.09723534,-0.019481624,-0.027858637,-0.05918772,-0.0019684916,0.046866722,-0.0060698097,-0.00077648053,0.03034978,-0.05474071,-0.013342831,-0.021493318,-0.06792456,-0.063520744,-0.05495867,0.002940243,0.022916507,0.01619371,-0.09981013,-0.08310203,-0.0045460765,0.12012482,0.030132925 +2.4.1.368,The enzyme has been characterized from the saponin-producing crucifer plant Barbarea vulgaris.,384,1.0,-0.052565522,-0.018821163,-0.0845199,0.0073146843,0.0054233037,0.07621797,-0.07481936,0.07134015,0.018083492,-0.039363828,0.04771444,-0.09781374,-0.0257165,-0.038327295,-0.093441814,0.009291534,-0.07165533,-0.015668541,0.021055201,-0.037304133,0.08475726,0.025078982,-0.06509942,0.032486733,0.062835604,-0.09011782,-0.023265952,-0.06615778,-0.0048371167,0.010251236,-0.06564466,-0.07150841,0.10398757,0.012767523,-0.030713586,0.030778028,0.06568863,-0.083400056,0.07727132,0.07499752,0.01934969,0.039168593,-0.03728448,-0.058832083,0.058763947,-0.009905792,0.037831195,-0.026259439,0.043971866,-0.01935393,-0.06541769,-0.05598283,-0.023714773,0.0037017802,-0.00037717834,-0.069701344,0.028623983,-0.0107170455,0.055606112,0.0934866,0.033298567,0.059838124,-0.012208868,-0.05621339,0.05456114,-0.05291667,-0.08174022,0.08524421,0.07849341,0.0025912658,0.011071036,-0.06673937,-0.08071712,-0.02361363,-0.072979644,-0.0034381256,-0.024891974,0.062669165,-0.0035172978,-0.040371865,0.031293605,0.022336021,-0.04393939,0.0127251865,0.014189192,0.049990203,0.0032652821,0.09659859,0.049525384,0.053285208,0.032137554,-0.016120307,-0.05295591,-0.06547788,-0.030842137,0.051156323,0.0068848864,-0.025028387,-0.011949331,-0.013770061,-0.026310295,0.020697638,0.069303855,-0.12659304,-0.11770162,0.045355394,-0.042049985,0.06199649,0.08825864,-0.00017353799,0.005390221,0.006708,-0.054072596,0.023482572,-0.027467242,0.11709841,-0.007140025,-0.030848972,-0.0385541,-0.010625972,0.01170992,0.02206786,0.069680594,0.06532695,-0.006771105,0.032548595,-0.050112225,3.0637903e-34,0.043617062,-0.009839523,-0.050140552,-0.012385716,-0.017083583,-0.02239074,-0.13078284,0.0415554,-0.0340312,-0.07071729,-0.05864785,-0.0888222,0.047019485,-0.02386818,0.02984684,0.0066795764,-0.0073242737,-0.05837281,0.08404436,0.0055988044,-0.03199342,0.008382274,-0.053438663,-0.020289784,-0.024362594,-0.02111548,0.061036844,0.015788404,-0.015764171,-0.02506271,0.07450035,-0.07488117,0.014802194,0.030426245,0.118404984,-0.0028721266,-0.008505865,-0.022956554,-0.025545413,0.045918494,0.049044088,0.0047177384,-0.003819478,0.04392656,0.08184097,-0.002191261,-0.06263691,0.011337344,0.038764562,0.03945634,-0.009862803,0.096696295,0.12948743,0.057228096,-0.019964885,0.08533668,0.02419074,0.040894527,0.05073721,0.015485918,0.031297043,0.0276046,-0.03774036,0.018768806,-0.03427147,0.04401488,-0.09341521,0.016146075,0.065968126,-0.00069564546,-0.017786685,-0.0841496,-0.07610203,0.013843529,0.04404364,-0.011464788,-0.02647464,0.02970629,-0.055400703,0.030457404,-0.04753562,-0.009356384,0.025088314,-0.018447708,-0.020979263,-0.0054701394,0.010864316,0.0054857,-0.023370184,-0.01711999,0.06166775,-0.04260636,-0.03282491,0.049545545,0.05508436,-5.3385195e-34,0.06765834,-0.10940993,0.08059975,-0.022997353,-0.06898522,0.028640134,-0.053010013,-0.04512692,-0.022172319,0.007211497,0.028867237,-0.028591216,-0.014971978,0.004085763,0.08039009,0.074376866,-0.037633285,0.09256182,-0.03225408,-0.008724982,-0.012859158,0.07306515,0.012107938,0.001383402,0.029746298,0.0073653315,0.036819205,0.10232086,0.036629725,-0.044353563,0.04750109,-0.059734505,-0.030378971,-0.04008864,-0.0637034,0.03532707,0.017109118,-0.024215586,0.068446204,0.11616427,0.04207633,0.09181121,-0.042115167,0.0015788404,0.029506749,0.059932902,-0.010743365,-0.010992933,-0.034717947,-0.0035233418,0.090273045,0.011673181,0.028820949,-0.031134108,0.042144183,-0.032199785,0.012946588,0.095260516,-0.048809938,-0.08093859,0.029819947,-0.07022692,0.034337714,-0.03465013,0.04804013,0.03457771,0.037242062,0.06330389,-0.0030193778,-0.04248152,0.042465113,0.00015208128,0.02846089,0.11061723,-0.057925902,-0.0047991322,-0.051426858,-0.069559015,-0.047580726,-0.06821295,-0.013208982,-0.009289472,0.03355013,-0.057169832,-0.029066699,-0.030857917,-0.0019284498,0.087411605,0.034790598,0.046631943,-0.016442334,-0.019598512,-0.054630406,0.08107018,0.15027359,-2.3066685e-08,0.0049885707,-0.07388428,-0.01278177,-0.023285111,0.009544094,-0.030030575,-0.033489216,-0.022665938,-0.01587617,-0.0447056,-0.068040766,0.035326526,-0.0700569,0.042557377,-0.03463815,-0.027886925,0.03089425,0.020668253,-0.013434292,0.05659617,-0.028204938,0.009098445,-0.0468958,0.043385584,-0.058799222,-0.12928054,-0.016295215,0.110809386,0.009288229,-0.06560737,0.024263779,0.046492618,0.018932605,-0.08166205,-0.10111629,0.05075289,-0.048879355,-0.056775115,-0.019456398,0.0026779035,0.0378768,-0.07305929,0.029493373,-0.01620659,-0.06807905,-0.05328376,0.06657785,0.048486218,0.021721866,-0.013321063,0.066096745,-0.014765823,0.068810165,-0.044908613,-0.053012326,-0.006414687,-0.020479381,-0.047909316,0.050243344,0.0033266419,0.0064191623,-0.029417392,0.15971912,-0.022661218 +3.1.1.106,"The enzyme, characterized from the bacterium Escherichia coli and from human cells, removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose, which are formed by the action of EC 2.3.1.286, protein acetyllysine N-acetyltransferase. The human enzyme can also remove ADP-D-ribose from phosphorylated double stranded DNA adducts.",384,1.0,-0.042239204,0.00013452861,-0.05511405,0.02218118,0.028466308,0.006658518,-0.03295891,-0.015455556,0.0498199,-0.0061032185,0.07145258,0.036323864,-0.115687296,-0.005344899,-0.040426627,0.00634663,-0.078719534,0.03324628,0.029467953,-0.06705893,0.0987582,0.031856902,-0.026072709,-0.05749536,0.048983533,-0.049325455,0.046763826,0.0072736368,-0.025291432,-0.10671026,0.04223513,-0.09822996,0.073407106,-0.06613546,0.07538699,0.024456192,0.04120797,-0.03568631,0.043432496,0.035831306,0.03217674,0.0066640275,-0.071294524,-0.0044432757,0.033658147,-0.017741319,-0.061272454,0.024116565,0.039139587,-0.0018706433,0.008827178,0.04168515,-0.033042878,0.0030304973,-0.0027586939,0.044843305,-0.025342857,-0.055792715,0.011990118,-0.02571145,0.07374439,0.015762921,-0.0025351893,0.010616695,0.06928434,-0.062150925,0.12096115,-0.10923232,0.014336743,0.03018885,-0.06256641,-0.056983218,-0.022768509,0.07403043,0.06555057,-0.056386996,-0.075205564,-0.08280835,0.093090095,0.023361593,0.03720519,-0.066700324,-0.038275555,0.044789363,-0.006110267,0.021511452,-0.012536998,-0.016870242,-0.0069926404,0.03519294,-0.06026704,-0.084736474,0.06662375,-0.048288118,-0.014979315,-0.012981372,0.032809556,0.06466444,-0.023536539,-0.01885087,-0.021968426,0.09693225,-0.023803864,-0.077465,-0.021107959,0.016833201,0.008480888,0.08137432,0.035375852,0.009084377,0.009013662,-0.011198333,-0.012400523,-0.032586828,-0.010243841,0.09354191,-0.0010397779,-0.09973124,0.0058156885,-0.03332605,0.027464705,-0.03419564,0.054732207,0.13189027,0.014700785,0.07913201,-0.050876874,2.3066434e-33,0.01575976,0.040065333,0.046115585,-0.0020405473,0.03007702,0.0055551226,-0.11697044,-0.017984128,0.0064908536,-0.0038630893,-0.070841864,-0.15375218,0.090283014,0.06975673,0.00014488221,-0.013527675,-0.035158437,-0.02487033,0.041811273,0.04194466,-0.0341901,0.059284177,-0.017939711,0.07825847,0.036918804,-0.022283824,-0.06725497,0.030687967,0.07990816,0.017970903,0.031794805,-0.039556447,-0.12031105,0.05496967,0.009459924,0.0019318686,0.013689916,-0.050676934,0.06794768,0.07156686,0.037749905,0.044825394,0.035439126,-0.03141755,0.04271982,-0.019078588,-0.029632885,0.043571983,0.013188233,0.01714806,0.041052107,-0.02494051,0.094436206,-0.04619079,-0.049541656,-0.0022091945,-0.068988085,-0.010265121,0.030413263,0.069024414,-0.00050114305,0.059810203,0.0046660984,0.04902428,-0.067950055,-0.0033105018,-0.010002346,-0.099481605,-0.0045089102,0.019842248,-0.08335224,-0.032068733,0.093525104,0.013439814,0.010325367,-0.016706092,-0.050028604,0.035010785,0.015055258,0.012327132,-0.045286387,-0.02268585,0.012856966,-0.021811273,0.019488852,-0.015522314,-0.03330087,-0.061629497,0.05827936,0.065598495,0.05110079,-0.021862118,-0.10006878,0.0945879,0.028685592,-4.253586e-33,0.059940886,-0.056382794,0.051035058,-0.08814108,-0.09616025,0.06946455,0.050053477,0.026358819,0.036481015,-0.047851615,0.11021385,-0.027529826,0.051325303,-0.0650958,0.059933323,-0.021958664,-0.035659287,0.037758037,-0.030349107,0.061686926,0.020346396,0.009065583,0.012193584,0.03165291,0.0775797,0.0044626957,-0.04783952,-0.0025440182,0.053251315,-0.026987452,-0.026810043,0.018429924,-0.016798029,-0.02791032,-0.071163,0.039402943,-0.039024312,0.098816745,-0.025566304,-0.0010359773,-0.049831387,0.07880036,-0.047383323,0.046662487,0.03210449,0.113648325,0.031078734,-0.0029486779,-0.071454085,-0.05745122,0.0014797585,-0.008007989,-0.030064281,-0.007079801,-0.012253925,0.06334074,0.020435186,0.012161159,0.04979072,0.017557446,-0.03836845,0.0006906156,0.02770313,-0.008410203,0.062353346,-0.011159406,-0.022145148,0.079410225,-0.034307096,-0.06363637,-0.014116604,0.010138612,0.006338623,0.02157191,0.028719729,-0.049389083,-0.1509337,-0.06953068,-0.013819025,-0.0692818,-0.051086932,-0.014723531,-0.01168157,-0.035897728,-0.0728412,-0.08266218,0.01470258,0.09625767,-0.058394827,0.050850928,-0.06857695,-0.0033929164,-0.084632084,-0.00063315785,-0.0009124175,-4.154389e-08,0.061741635,-0.003434333,0.069728814,-0.09373188,0.01645254,-0.0045609814,-0.00861199,0.104025245,0.09675164,-0.08229437,-0.09958788,0.1629124,0.0045280457,-0.013604497,0.008906052,0.016108802,-0.050528843,0.03921942,-0.0026895546,-0.006217704,-0.03094399,0.006986473,-0.10741368,0.057807177,-0.012422788,-0.03359421,0.04410899,0.045090172,-0.0008802042,-0.040322855,-0.0062814374,0.0075233877,0.00448307,-0.004597595,-0.059768993,-0.011920184,-0.037015446,-0.040476713,-0.011492799,0.03903373,-0.011264021,0.010131389,-0.06762228,0.022702122,0.0034870147,-0.029955193,0.018739462,-0.010350538,-0.040148467,-0.03785655,0.046326507,-0.05211636,-0.034821916,-0.07424032,-0.07865058,-0.03374056,-0.050079502,-0.07978265,0.012269034,0.020048974,0.034508232,0.008010256,0.1350466,-0.043381885 +3.7.1.24,"Requires Zn2+. Isolated from the bacteria Pseudomonas fluorescens, Pseudomonas sp. YGJ3 and Mycobacterium abscessus 103. It reduces the antibiotic activity of 2,4-diacetylphloroglucinol.",384,0.99999994,-0.08351858,-0.0015469241,-0.059882257,-0.030357558,0.059722133,-0.023799172,-0.026854161,0.091755316,-0.022525992,-0.03434736,-0.017765438,-0.046027105,-0.01852766,0.15015103,-0.09987316,0.055254444,0.0138949435,0.0766164,0.008701911,0.0053355284,0.023262355,0.13209268,0.056437008,0.025612378,-0.05721237,-0.007374349,0.030728078,0.035262972,0.045429423,-0.03096032,-0.003864312,-0.028364481,0.12983777,-0.083844304,0.08835344,-0.016560672,0.023289226,0.013670382,0.11166191,0.050122857,0.038841378,0.020858552,0.048794683,0.004534217,0.033567753,0.032500602,0.019326657,-0.00644224,0.055369962,0.015545176,-0.05747878,0.020297516,-0.00263144,0.10413325,0.064505726,0.052179445,-0.12071783,-0.0034346639,-0.04002375,0.053503305,0.061351568,-0.03199883,-0.007927492,0.0042576175,-0.025714744,0.024338359,-0.022542303,-0.038036466,0.032678254,0.018133549,-0.05660899,-0.011591305,0.030218618,0.038427867,-0.061359417,0.015429378,0.064819254,-0.11301421,-0.006323159,-0.074743494,0.010755612,-0.035429444,0.08329241,0.10735219,0.06259104,-0.03971898,0.020374795,0.0048452807,-0.01614619,0.069917575,0.089205086,0.031304613,0.03575042,-0.047884334,-0.06247409,0.023288269,0.018238885,-0.019118238,0.011056863,0.034438413,0.018723372,-0.033301607,0.059746955,-0.081605725,-0.04183146,0.014333264,0.04548402,-0.019103734,0.0038536105,0.04094966,-0.0028424233,0.016062587,-0.085879676,-0.075718164,-0.0454422,0.021160478,0.10104503,-0.053862225,-0.0785254,-0.010060728,-0.003337863,-0.08856468,0.018116895,-0.013446061,-0.026829837,0.025835093,-0.06321962,5.5298175e-33,-0.042565025,0.060447183,-0.06461225,-0.004263439,0.02174526,0.019841,-0.047615267,-0.03703843,0.010455639,-0.09779398,-0.015899856,-0.07270695,0.024152096,0.052315358,-0.07064957,-0.00067677785,0.005158829,-0.042846065,0.027642231,0.019435778,0.098752625,-0.002941444,-0.06306322,-0.022425778,0.05276176,0.0555264,0.01705334,-0.025538389,0.031258464,-0.029062875,0.07463181,-0.062777534,-0.060800426,-0.012918887,0.093487486,0.010565637,-0.083610095,-0.02963471,0.022115758,0.0026649593,-0.024857415,0.0538284,-0.021850977,-0.0041889525,0.12953757,-0.05323062,-0.09721187,0.09909297,0.0030308557,0.028920323,0.05777387,-0.05435123,-0.089182355,-0.012730489,-0.028469788,-0.041025802,-0.029889107,0.023073683,0.07693038,0.0038589223,0.0015558625,0.035477504,-0.06406086,0.073466696,0.028259752,-0.013983688,-0.06257137,-0.038777184,-0.028721247,-0.00024378659,-0.05920688,-0.052979775,0.025873624,0.020470398,0.0077279336,-0.08532368,-0.047212422,0.014481743,0.08306552,-0.041358855,-0.048026443,-0.060248803,0.056265894,0.029847112,-0.082728274,-0.011333986,-0.04431113,0.023468737,0.0032253359,0.002378312,0.020399066,-0.11825911,-0.04076696,0.04781049,0.009333547,-5.9037316e-33,0.07641587,0.014977509,0.077382065,-0.04736476,-0.03702676,0.066064715,-0.011780013,-0.073189676,0.04902581,-0.05214911,0.110716,0.02147229,0.050880324,0.0002985149,-0.0002684849,-0.007844908,-0.011410211,0.011360252,-0.0545615,-0.012505596,0.05781361,0.07817337,-0.0043650926,0.014575147,0.035749793,0.032447144,-0.019317629,0.059828233,0.049407,0.10638068,-0.06768521,0.02739379,-0.07802509,-0.15901569,-0.040337097,-0.025556749,-0.024608193,-0.017274685,-0.1094371,-0.06933317,0.015956644,0.0040887743,-0.056595754,0.061456494,-0.06775296,0.10044753,-0.02088048,-0.032168083,0.0024230173,-0.030692719,-0.019755742,0.00322674,-0.049013063,0.013835583,0.027820526,0.018234469,0.022822173,-0.0061908234,0.015399269,-0.0025415302,-0.034841932,-0.066623144,0.022705432,-0.05128975,0.043975774,0.035695173,0.023569865,0.1437612,0.04585702,-0.059117977,0.025326574,0.1189885,0.06053428,0.0011294639,-0.1379313,0.018146964,-0.049754974,-0.06701364,0.05517817,0.051774915,0.022894943,-0.05044419,-0.059401467,0.009549182,0.011635223,-0.06153573,0.03405538,0.05904227,-0.072253436,-0.029258,0.024970936,0.0317303,-0.0053026406,0.010834789,-0.0754117,-3.6723897e-08,0.016497375,-0.064281665,0.03369748,-0.055584017,-0.034091353,-0.018583838,-0.048104316,0.041590847,-0.0061460123,-0.043503813,0.014357213,0.10819271,0.02622837,0.003135356,0.052844886,-0.014319809,-0.01897995,-0.05220766,-0.021577347,-0.003120347,-0.06007528,-0.027320936,-0.08474815,0.004962503,0.024185501,-0.030933777,0.07576319,0.017078154,0.027019193,-0.012668198,0.016165273,0.010546275,0.042503595,0.013618595,-0.07377165,0.051529057,-0.010961999,-0.07056156,-0.032947462,-0.049675614,0.018394446,-0.003535553,-0.00015456491,0.033047434,-0.037342653,-0.062387563,-0.0065155514,0.0054631825,-0.015979884,-0.04688319,0.042040315,-0.06406003,0.024296656,-0.005931483,-0.037397757,0.064306915,0.041778482,-0.02396603,-0.05619891,0.0029172937,-0.030748673,-0.057077218,0.088633955,0.02500556 +3.7.1.25,A bacterial enzyme that participates in the degradation of toluene and 2-nitrotoluene.,384,1.0,-0.05885596,-0.0588163,-0.036500417,0.026476005,0.096647665,-0.009117007,0.000672567,0.023613801,0.03668485,-0.0024686267,-0.07917328,-0.022555636,-0.022361076,0.0964605,-0.107552335,0.041741744,-0.056939762,0.007228735,0.022832807,-0.035104055,0.043158602,0.025098998,-0.04063398,-0.046769127,0.011670749,0.030223412,0.005484202,-0.098782115,-0.05125946,-0.033107705,0.030217238,-0.004729463,-0.007893372,-0.029689768,0.07187144,0.10133127,0.01809838,-0.0357483,0.03125997,-0.05152487,-0.005424712,0.04891058,-0.046802256,-0.055491667,0.051204957,0.063805126,0.02572623,0.011130626,0.04655326,-0.066835,-0.017881354,-0.0009580699,0.049865678,-0.008793791,0.048385642,-0.024998948,-0.0046034427,-0.045859072,-0.03533143,0.032053635,0.11144708,-0.03653742,0.031776696,-0.0036964912,0.041316904,-0.056636818,0.06523828,-0.038123295,-0.03794093,0.030954257,-0.13073397,-0.037571374,-0.011947481,0.045174632,0.048764225,-0.04089671,0.030922849,-0.042921007,0.04765784,-0.08000644,0.05941202,0.016108442,0.016775863,0.060986035,0.029859422,-0.011223839,0.0069141043,8.858189e-06,0.0273241,0.021842942,-0.051389012,0.062466726,0.09383758,-0.033507776,-0.08657001,-0.009822435,-0.022530671,0.008513164,0.027115148,0.0282552,-0.046514817,-0.037487432,-0.03519935,-0.092291206,-0.07802189,-0.035321508,0.021623941,0.06402005,0.15632004,0.038248625,0.01671173,0.049945325,0.011639048,0.008109952,-0.03025462,0.051954016,0.070793204,0.005436588,-0.07372742,0.08738738,-0.015833667,-0.044630416,-0.024099436,0.06809569,-0.12665647,0.024626466,0.027076611,-1.6759493e-33,-0.0038312322,-0.006032495,-0.0019559497,-0.0051966626,0.0014488866,-0.06515936,-0.07233096,0.008778664,0.018756451,-0.048491,-0.01807191,-0.12461398,-0.03220468,-0.033628307,0.021563044,-0.004108361,-0.025939316,0.056369405,0.06155033,-0.021361573,-0.093430586,0.07672456,-0.06312236,0.01680934,0.11669026,-0.008238417,0.02791125,-0.034877215,0.017021121,-0.05122965,0.056229178,-0.073403336,-0.06632142,-0.007008469,0.04888011,-0.044916056,0.0020727178,0.045608606,-0.025618114,0.007507804,-0.028884513,0.0265612,-0.02289252,-0.004065159,0.034496658,-0.00048226904,0.0035388246,0.083658,0.023780838,-0.0014710084,0.008190924,-0.05187676,0.058629334,-0.08589045,-0.0838248,0.080627196,0.039852735,-0.019553868,0.058359098,-0.016258314,0.016935635,0.05211319,-0.09505706,0.0064553916,-0.01068717,-0.0017189217,0.017962798,-0.011233582,0.038251065,0.02927219,-0.13523048,0.04386554,0.061818875,0.030775588,0.0064899316,-0.03471326,-0.08581463,-0.020807091,0.08192626,-0.047028445,-0.007292739,-0.060211007,0.03650453,-0.037513167,-0.06291339,-0.00019989115,-0.05904766,-0.0438519,0.0372562,0.019596582,0.074088916,-0.11004394,-0.07701578,-0.02211116,0.007291818,-6.129911e-34,0.037347265,-0.062612966,-0.03632099,0.009411814,-0.04251684,0.05539558,-0.044624615,0.017060379,-0.05497334,0.008736045,0.08024663,-0.06545848,0.045884524,-0.034492657,0.028813073,0.021140872,0.011060836,0.03893519,-0.013554325,-0.08136028,-0.02842756,0.031080445,0.030039717,-0.043941513,-0.07688355,0.07823483,-0.017370397,0.07845986,0.09610612,0.020502184,0.04921806,-0.009579454,-0.028238188,-0.06989312,0.039155934,-0.0022088331,0.0075466107,-0.021771431,-0.056351792,-0.04096585,0.03645631,0.035270415,0.030950207,0.045698036,-0.016709836,0.05875754,-0.08797271,0.0026273124,0.00069403806,-0.087370604,0.015941208,0.0042142263,-0.026973717,-0.037729025,-0.023210315,0.035143312,0.040817816,0.022034936,-0.020685302,0.02860273,-0.04211906,-0.044109095,0.067966975,0.0979681,0.0009005278,0.03368301,-0.07265821,0.10216221,0.01839672,-0.01696689,0.043759014,0.055912312,0.08450303,0.031092314,-0.09639489,-0.0012722838,0.016663998,-0.0678549,0.021309955,-0.02688392,0.013603427,0.004353771,-0.051847372,-0.03831726,-0.015178414,-0.07564224,0.044878077,0.13020466,0.037233014,0.0008001263,0.00056719116,-0.018867726,-0.11369463,-0.023628518,-0.051962454,-2.3565102e-08,0.044910084,-0.055520885,0.06406907,-0.060404103,-0.02080029,0.019051895,0.08053871,0.08313289,0.093858644,-0.07378825,-0.018578218,0.07930282,-0.022131434,-0.05887491,0.0316556,0.037521992,-0.04452212,-0.064036705,0.0035791912,0.0011242605,-0.07938752,-0.0022982191,-0.08763327,0.019007348,0.0056976685,-0.039812364,0.040913608,0.062080998,0.021186026,-0.075952634,-0.032792278,0.066995725,-0.012392821,0.008001551,-0.07260293,-0.015745457,-0.057311818,-0.04971426,0.0015119903,0.08715397,0.015659647,0.13320693,-0.07129705,0.028884353,0.04269258,0.020900622,0.023055682,0.01165167,-0.009033255,-0.021756293,0.024217462,0.002850593,-0.0760349,0.0027647926,-0.13713573,-0.0054075536,0.0061939633,-0.004601547,-0.01171129,-0.04361237,0.03848212,-0.026486637,0.15560298,0.051744875 +4.2.3.201,"Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrenol, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.202, hydropyrenol synthase, and EC 4.2.3.203, isoelisabethatriene synthase.",384,1.0,-0.04629766,-0.03596501,-0.13762408,-0.034775585,0.041895896,0.04551026,-0.049849954,0.0736193,0.05570529,-0.0664787,0.081883006,-0.09178787,-0.0030414886,0.002851745,-0.08036519,-0.030884486,-0.030996948,-0.019584233,0.08693583,-0.02269365,0.05038253,0.06917065,0.02549706,-0.004876131,0.08954165,0.055833068,0.048179407,-0.023911124,0.0318811,-0.052088805,0.02923769,-0.07213724,0.030053124,-0.097939536,0.14976425,0.09481303,-0.04091967,-0.011999667,0.12872624,0.09337411,0.034267582,0.0038894247,0.011781836,-0.038701996,-0.090841904,0.005510613,0.020673966,0.070230424,0.006696321,-0.071907185,0.005711863,-0.052737758,-0.036853783,0.001970267,0.0047043925,-0.06249676,0.032382894,-0.020822661,-0.016369032,-0.0066459854,0.05410345,0.019627126,0.006543268,-0.07913821,-0.048838127,-0.041482054,0.01961027,-0.017870557,0.1027929,-0.015253541,-0.099492855,-0.018275442,-0.016377397,0.026277905,-0.08225506,0.022095952,0.018271435,-0.03224429,0.0037003986,-0.014207155,0.03595339,-0.019040696,-0.02030857,0.059763577,0.015950855,-0.011509227,0.020830087,0.046094973,0.06992335,0.01892311,0.012993272,0.009651991,0.024444774,-0.056505296,-0.09556537,0.056715738,-0.041532252,0.03636575,0.04319024,0.012091554,-0.01249916,-0.011888078,0.02301656,-0.059774928,-0.052963383,0.047279254,-0.057560973,0.022546541,0.087986305,-0.0032345837,-0.021486513,0.027790742,-0.026535925,0.0072784405,0.032962497,0.00856126,0.076217115,-0.07517788,-0.04611301,-0.021293284,-0.014787668,-0.02795893,0.08391834,0.027287897,0.0062802625,0.067710705,-0.036721997,3.8104627e-33,0.052152596,-0.013339887,0.06903263,-0.031995468,-0.025721889,0.031570178,-0.04518962,0.05370887,-0.007751032,-0.124848574,-0.05859766,-0.11277567,0.00054101995,0.02045334,-0.04134937,-0.04240646,0.033849742,0.06729369,0.10445747,-0.054323986,-0.03829811,0.069984764,-0.030561367,-0.021618228,0.034586206,0.0071635656,-0.016383765,-0.03694631,0.14405169,-0.034654327,0.04982565,-0.08468419,-0.06620141,0.023180619,0.030022405,-0.0003726076,-0.055779234,-0.065522954,0.008539944,-0.0069033117,-0.0093484465,0.022556521,0.03967537,-0.010898545,0.08672271,-0.009641418,-0.009331564,0.038635284,0.046664163,0.005884873,-0.027708491,0.009565347,0.05291445,-0.047715854,-0.0910047,0.010482808,-0.0064461227,0.008688223,0.08687012,0.067797385,0.0052567706,0.16535182,-0.016770922,-0.0034929013,0.071720086,0.046554573,-0.0715366,-0.03016052,-0.005886019,0.08560208,-0.077779435,-0.054498967,0.049144417,0.012553418,0.015187726,0.014813325,-0.10214334,-0.056263518,0.01508311,-0.037470933,-0.06278215,0.002219904,0.011269271,-0.058457278,-0.048650622,0.035350576,-0.060967617,-0.04232227,0.042482123,0.12825765,-0.008091886,-0.057070065,-0.118441254,0.03968199,-0.023261057,-3.9092123e-33,0.06606849,-0.07181801,-0.01073012,-0.07339398,-0.04709714,0.08870838,-0.050101288,0.048949063,-0.055423394,-0.009230717,0.03563177,-0.03627016,0.014561564,-0.03378634,-0.01985634,-0.0063762,0.039611943,0.13108595,-0.024574416,0.017609129,0.03615999,0.07090361,0.030586338,0.037692152,-0.016853174,-0.029791975,0.083215795,0.009862808,0.008548287,0.072271526,0.01628492,-0.027147615,-0.041311055,-0.055248115,-0.06466445,-0.00021282745,-0.0956322,-0.0056340517,0.05960961,0.021046055,-0.016008021,0.020526107,0.009436365,0.07239575,0.060699634,0.047705587,-0.059057098,0.03068233,0.01673832,-0.0003184762,-0.028334497,0.0038448735,0.0049288436,-0.04677664,0.010414739,-0.006333672,-0.032321464,0.011869528,-0.013560589,-0.055232227,-0.025308669,-0.023876285,-0.051853944,-0.037749425,0.11877985,0.07024088,0.009092541,0.089755245,0.03454714,-0.043456826,0.07883186,-0.0130087035,0.02951586,0.032680236,0.031169761,0.04185536,-0.03775908,-0.08242878,-0.0035441516,-0.03016077,0.051147025,-0.02069185,0.025578907,-0.092271104,-0.0022745545,-0.028784007,0.046070278,0.0041466933,0.0049458966,0.072863266,-0.0019652098,0.051161326,-0.044784732,0.06602759,0.07721177,-3.7465135e-08,0.025613142,-0.00455976,0.12296699,0.014177144,-0.007993973,-0.026104739,0.012153953,-0.046446107,0.00763827,0.0396121,-0.056592565,-0.03010337,-0.005655871,0.00456637,0.03522496,0.017358646,-0.008525445,0.004215626,-0.040690612,-0.04339262,-0.050220363,-0.030466354,-0.042853847,0.06397786,0.001305294,-0.07350673,0.06505104,0.022400633,0.021311902,-0.0031813933,0.04250921,0.013740394,-0.03139777,0.007693735,0.027853794,0.018862842,-0.08458275,-0.019425552,-0.030678425,0.030189933,-0.020767266,-0.04123463,-0.069130965,0.017913627,-0.016609387,0.067849495,-0.052339077,-0.00048548312,-0.072548226,-0.02174734,0.083496004,-0.022471765,0.0351918,0.013546121,-0.04870518,0.017029038,-0.034245335,-0.08137561,-0.08464528,-0.031357173,-0.005515588,-0.024701284,0.17061572,0.058595385 +4.2.3.202,"Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrene, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.203, isoelisabethatriene synthase.",384,1.0,-0.047351632,-0.03423921,-0.13474753,-0.03031154,0.041555002,0.04716541,-0.04301404,0.07727854,0.05167411,-0.060776673,0.07682966,-0.097323455,-0.0035031247,0.005187151,-0.07845229,-0.035074577,-0.028710214,-0.022688663,0.08589207,-0.02352502,0.05107913,0.07173353,0.026845466,-0.0069076475,0.095532864,0.054958798,0.048563633,-0.026525782,0.030712975,-0.055543337,0.024011698,-0.07484652,0.02392573,-0.09014758,0.14529206,0.09512389,-0.037999585,-0.015903821,0.130257,0.09443423,0.034837484,0.010341388,0.011659076,-0.040837135,-0.09267111,0.01088717,0.024540149,0.06397012,0.005563344,-0.075054534,0.005647974,-0.059481967,-0.042405516,0.0033933413,0.0073269326,-0.06581975,0.042011563,-0.019893352,-0.016545087,-0.011445428,0.055817332,0.01379502,0.014244141,-0.08089563,-0.04743984,-0.04971495,0.019298822,-0.016329406,0.09759009,-0.02462607,-0.09279555,-0.017288541,-0.03059262,0.02697267,-0.07615976,0.028594546,0.008635578,-0.026768766,-0.010907685,-0.010595918,0.037222315,-0.018835848,-0.0130393235,0.056307446,0.017796665,-0.012818606,0.020074895,0.054704055,0.07402706,0.015833657,0.009377997,0.014021844,0.023968088,-0.056941774,-0.0988197,0.05326449,-0.03664078,0.037658073,0.04260005,0.015203028,-0.012449827,-0.013388951,0.01953309,-0.05373826,-0.050245874,0.042020544,-0.05151972,0.024905862,0.0827259,-0.00506847,-0.02383221,0.030617895,-0.01845945,0.0054437155,0.03052202,0.011430708,0.07799307,-0.07419778,-0.043776575,-0.014744231,-0.015397569,-0.025081571,0.08489783,0.029927079,0.009215085,0.06705704,-0.044615418,3.7188946e-33,0.054933682,-0.012621129,0.07244068,-0.033099994,-0.030934092,0.034039002,-0.049422234,0.052222136,-0.0048493603,-0.12855606,-0.060008664,-0.115641356,0.0018730029,0.01638426,-0.038013287,-0.04146449,0.036110476,0.066338554,0.09760675,-0.05949425,-0.039287448,0.06701481,-0.031933606,-0.02075971,0.0353267,0.0063096057,-0.0086326655,-0.03403877,0.14212607,-0.038678586,0.04396603,-0.08447977,-0.06540439,0.016988795,0.036398962,-0.005644746,-0.051820368,-0.06297831,0.0038289076,-0.0077547706,-0.00885236,0.020003177,0.043228652,-0.022240223,0.08851413,-0.011743267,-0.010632502,0.036136318,0.049481016,0.010214159,-0.027466292,0.009862836,0.057563484,-0.0407225,-0.094488166,0.014796982,0.00072117685,0.0070956554,0.090795666,0.06611271,0.009065357,0.15809257,-0.018705806,-0.006875091,0.06584641,0.05070292,-0.07583633,-0.030562134,-0.008171587,0.091525935,-0.07985116,-0.06519551,0.05363251,0.009471949,0.017009312,0.013044916,-0.10412435,-0.05674279,0.015039229,-0.04002442,-0.06278225,0.001279436,0.0074204793,-0.05959321,-0.051280793,0.035901677,-0.06077427,-0.044849385,0.037212834,0.12879272,-0.008088816,-0.05129699,-0.12746878,0.031521596,-0.02009284,-3.874998e-33,0.06559017,-0.06423637,-0.014189362,-0.077491134,-0.046032272,0.088183016,-0.057108216,0.05285703,-0.061248954,-0.016519014,0.031763617,-0.039136622,0.014227574,-0.035971448,-0.020938009,-0.009204736,0.035164237,0.13134249,-0.0125174485,0.017439028,0.036809187,0.06328356,0.031118685,0.033342972,-0.015605037,-0.032766577,0.079000585,0.022277646,0.008755019,0.06866493,0.009949492,-0.024716474,-0.042974643,-0.054748252,-0.07054825,-0.0016584024,-0.09036542,-0.004057692,0.05781091,0.024982981,-0.016417395,0.014264996,0.017465904,0.08352375,0.06321004,0.04887945,-0.06236086,0.03347902,0.020707998,0.002702647,-0.02771531,0.0022409668,0.0059099905,-0.053918317,0.010328111,-0.0074286186,-0.029372355,0.0133644985,-0.01220641,-0.055564255,-0.016673464,-0.020727655,-0.04838297,-0.036681365,0.11413878,0.06891478,0.0022920566,0.090149365,0.04016318,-0.036956586,0.075078174,-0.015153887,0.028580016,0.029327618,0.034202818,0.037355468,-0.042373497,-0.07874183,1.5574951e-05,-0.027158381,0.04443137,-0.015352533,0.024047298,-0.09102305,0.0037849718,-0.026621226,0.045293324,0.0024380104,0.0042464905,0.06877728,-0.0040238514,0.053166144,-0.037199896,0.06960664,0.069537655,-3.758407e-08,0.032998543,-0.010056693,0.12358769,0.020113034,-0.008217195,-0.03326738,0.01162586,-0.047319453,0.010140024,0.04050379,-0.054490425,-0.035554618,-0.007956335,0.009498637,0.036643192,0.023067111,-0.010549541,0.007182862,-0.043815732,-0.04059334,-0.04854858,-0.033382267,-0.044427324,0.07044088,0.003527923,-0.067703165,0.06239948,0.028220523,0.022715688,-0.00419982,0.043672174,0.013070124,-0.028491898,0.004434547,0.022695862,0.019215925,-0.08455014,-0.015633896,-0.028848987,0.02717179,-0.01882429,-0.03473248,-0.07119042,0.017252455,-0.015787292,0.07480279,-0.050319813,0.0044905753,-0.068516284,-0.025478866,0.08633892,-0.020732453,0.033915747,0.016709674,-0.053038307,0.018860348,-0.032269374,-0.077778764,-0.08388409,-0.030840999,-0.0040524025,-0.02552315,0.17390871,0.056155354 +4.2.3.203,"Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is involved in a 1,3-hydride shift to the side-chain. The enzyme also produces hydropyrene, hydropyrenol, and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.202, hydropyrenol synthase.",384,1.0,-0.054441385,-0.030210117,-0.115967445,-0.057477128,0.0456405,0.03786988,-0.06311909,0.05675045,0.0392026,-0.077871576,0.07531247,-0.095656134,0.024899198,0.0065647536,-0.04140032,-0.010188136,-0.06791879,-0.04994763,0.091181286,-0.016003827,0.036589596,0.08646463,0.01814394,0.017545413,0.04144911,0.065931015,0.06754398,0.015527416,0.006033565,-0.06751228,0.03931606,-0.045241162,0.0234799,-0.090431005,0.13383357,0.10516665,-0.04105384,-0.023216607,0.12476825,0.11142145,0.06627976,0.004990037,0.024578022,-0.042849537,-0.09510537,0.022766987,0.0302465,0.085505076,0.014518556,-0.04278605,0.028992686,-0.0447009,-0.024894187,0.0099606775,0.011590237,-0.027887579,0.0027696441,-0.0050186464,0.0010676711,-0.013039842,0.021327334,0.04693566,0.03075408,-0.06228551,-0.045492586,-0.062120613,0.007300428,-0.027003704,0.0729818,-0.036866475,-0.09852829,-0.024773262,0.0012671399,0.020747509,-0.06137946,0.0038589365,0.019716952,-0.051762644,0.017109422,-0.04102605,0.027390163,-0.011653946,-0.0013923075,0.09042341,0.015874485,-0.040732592,0.0079687,0.034248557,0.059106927,-0.004773158,0.020197941,-0.054236636,0.013155632,-0.052184604,-0.086843036,0.065896966,-0.03043024,0.0051771794,0.056458395,0.0033746695,-0.018237157,-0.021650067,0.057396848,-0.037305973,-0.019742586,0.051817235,-0.05326541,0.044656977,0.07171431,-0.004054432,-0.011394055,0.007350626,-0.004122173,-0.013454591,0.018827295,0.009172701,0.052327644,-0.058961377,-0.059295435,-0.05679423,-0.009301649,-0.028907297,0.1006497,0.027945826,0.01043645,0.061407767,-0.07825729,2.0797684e-33,0.056972697,-0.061494607,0.053130712,-0.033604145,-0.028877016,0.016181042,-0.05175875,0.057852987,-0.013824656,-0.11466878,-0.048437856,-0.091301024,0.020892324,0.034327667,-0.06935422,-0.055550434,-0.0011777349,0.04917549,0.06765761,-0.03742015,-0.04129361,0.07149755,-0.020259995,-0.018633977,0.011074171,-0.01586976,-0.0210666,-0.049515564,0.18281445,-0.033899944,0.03827314,-0.100663185,-0.05636311,0.03604232,0.031392124,0.015485997,-0.08761014,-0.08091509,0.010027488,0.0102932425,-0.0060811285,0.01985837,0.02641457,-0.04956974,0.05331436,0.018970013,0.0046531386,0.02648634,0.00017273614,0.011935031,0.006728718,-0.0008679718,0.0464541,-0.0373381,-0.09843372,-0.021489386,0.0038780076,0.026505424,0.0857315,0.06257961,-0.013349803,0.16132261,-0.029051302,0.0021667832,0.061903145,0.03947353,-0.06261517,-0.03188291,0.007772901,0.090320915,-0.0648954,-0.022966454,0.046814118,0.008425842,0.021294884,0.023154816,-0.09694766,-0.052533668,0.027601674,-0.013458117,-0.051146884,-0.003556212,0.046215083,-0.022166332,-0.06478425,0.033478178,-0.0460854,-0.043263376,0.0151003,0.10830266,-0.004530069,-0.053873647,-0.0674252,0.030780861,-0.0022569876,-2.764388e-33,0.034244597,-0.069147885,0.04467049,-0.08317799,-0.025776958,0.0986106,0.0011642778,0.03350757,-0.05551141,-0.017343191,0.035746507,-0.018231964,-0.0030946147,-0.060064103,0.025066894,0.0059048324,0.010096561,0.13849485,-0.042935085,0.025947928,0.043043803,0.060460057,0.032528773,0.026392773,-0.0031857537,-0.024960773,0.07043478,0.01293036,0.03341749,0.08500894,-0.014458148,-0.011954025,-0.039133452,-0.04918639,-0.067468666,0.025952382,-0.11642417,-0.015338569,0.0501177,-0.013352417,-0.003670162,0.007346328,0.02543376,0.08058299,0.04469388,0.089068115,-0.059245586,0.060137868,0.024678392,0.010535205,-0.056788877,0.008169215,0.011129192,-0.033470564,-0.003848692,-0.011957073,-0.011248716,0.009699761,-0.0026020368,-0.06324594,-0.05655267,-0.019984648,-0.05327413,-0.035460405,0.0856427,0.03671843,0.012757783,0.024893869,0.06159023,-0.05845841,0.08431065,0.005862061,0.045955624,0.011625958,0.04657357,0.02299817,-0.05108816,-0.10586557,0.012502128,-0.018313853,0.029314969,-0.008117949,0.028091352,-0.05987802,0.018548956,-0.040565968,0.03077194,0.0045520533,0.01439929,0.060059056,0.016108023,0.056225605,-0.04561379,0.060429372,0.07878059,-3.891861e-08,0.0258879,-0.045025498,0.11773446,0.0033599536,0.012682675,-0.00062658207,0.0051984256,-0.021115467,0.024905454,0.037897844,-0.00690661,-0.016920375,0.0022423582,-0.03464053,0.02349087,0.0136926975,-0.0045734225,0.010762372,-0.044536613,-0.06415743,-0.06709979,-0.049246453,-0.05808214,0.074592255,-0.0070131975,-0.06457347,0.034549545,0.010999471,0.00044744488,-0.04116303,0.05882288,0.009576253,-0.049272202,0.009535925,0.037950426,0.009467768,-0.08334445,0.018552179,-0.018743021,0.04269693,-0.015068194,-0.033542484,-0.06725868,0.00630515,-0.02350502,0.07011462,-0.08182983,0.0071707605,-0.0778658,-0.014935063,0.072398625,-0.024507714,0.06791239,0.0053834775,-0.05870693,0.010678671,-0.033701025,-0.11542707,-0.09892755,-0.028519541,-0.014983253,0.03435187,0.20481397,0.060937665 +6.2.1.57,"This mycobacterial enzyme activates palmitate and stearate by adenylation, followed by their loading onto the polyketide synthase EC 2.3.1.287, phthioceranic/hydroxyphthioceranic acid synthase.",384,0.99999994,-0.024850849,-0.078816764,-0.050840423,-0.030016264,-0.016639825,-0.04497464,-0.0032037522,0.018857064,0.01370317,0.023950312,0.007416823,-0.05457083,0.0128553,-0.0084277885,-0.004594813,0.024485722,-0.011787057,0.03013728,0.017935857,0.012350981,0.09766601,0.09309372,0.03942648,-0.06470596,0.020589828,0.037076358,0.083646834,-0.0031290962,0.0032400389,-0.11744564,0.006283194,-0.045007534,0.053506333,-0.07532694,0.10884408,0.103891,-0.040831506,-0.092381924,0.07335346,0.010883073,0.118473224,-0.07041333,0.018421436,-0.03926561,0.007705636,0.046709735,-0.061071366,0.045260925,0.0005737509,-0.017963627,-0.03950415,-0.11583256,-0.014632932,-0.00569214,-0.0016055186,0.003865176,-0.0054536196,0.020134406,0.031969912,0.04416741,0.055882685,0.010395635,0.020675233,0.033965256,0.018737959,-0.08104323,0.033164673,-0.049128983,0.022679623,-0.012053099,-0.0838462,-0.0079360055,-0.022381175,0.08576703,0.015136838,-0.038730673,-0.03478759,-0.039495315,0.020078775,-0.006283781,0.0071946164,-0.01273322,-0.036298692,0.008864932,0.040162403,-0.030078946,0.12451502,0.008774908,0.020593962,0.08340173,0.052204072,-0.06839287,-0.024000121,-0.02246363,-0.049263664,-0.050166383,0.09090966,-0.0033868158,0.0031884543,-0.053281993,-0.0053805364,0.009546558,-0.004271171,-0.029338455,-0.016854784,0.008787411,-0.07755161,0.0024406135,0.062108517,0.09488468,-0.05601832,0.021214629,-0.030288644,-0.082693726,-0.037644733,0.1065836,0.02039076,-0.054206394,-0.05288642,-0.004487797,-0.0025246895,-0.107903086,0.0082582915,0.04537051,-0.11785599,-0.0063100345,-0.110435046,2.8162389e-33,0.057238426,-0.033365287,0.03898074,-0.047709834,-0.012115757,-0.07312964,-0.07676134,-0.011550888,-0.052106928,-0.16955489,-0.008997432,-0.08315184,0.043819144,0.14968118,-0.06933113,0.012496006,-0.034618422,0.05071655,0.04579054,-0.016155297,0.018328596,2.5539875e-05,-0.006384023,0.032416943,-0.026341436,0.02130945,-0.037527576,-0.007497487,0.10430291,0.012836664,0.032229576,-0.06264341,-0.064524226,-0.01603306,0.00496012,-0.0017287584,-0.0028914132,-0.13657403,0.03313196,0.026800208,-0.009304814,-0.05446907,0.06359605,-0.054990347,0.043197107,-0.032781098,-0.048634216,0.019412402,0.010584573,0.03475691,0.02324494,-0.032115914,0.04760539,0.0079679135,-0.05088428,-0.05245269,-0.062335797,-0.0313642,-0.029267568,0.02244818,0.037032966,0.07619437,-0.029314673,0.1134401,-0.12409802,-0.013329555,-0.08071016,-0.02365994,0.059018124,0.058104206,-0.03225145,-0.06488228,-0.008800717,0.006651607,0.06866389,0.0063489103,-0.052622396,0.006946217,-0.023890322,0.013003566,0.08434437,0.020206233,-0.03725963,-0.010745016,-0.0139069725,-0.021638036,-0.05817729,-0.051222835,-0.032364994,0.016317103,0.035510186,-0.067172386,-0.044906713,0.09661989,-0.058041822,-6.484203e-33,0.14079447,-0.0499716,0.09128506,-0.06704447,-0.03271812,-0.033197027,0.02938471,0.023346841,0.0005176224,-0.03429638,0.015685339,-0.02518313,0.031348832,-0.009157652,-0.035022203,-0.0054600732,0.021486256,0.03573822,-0.056599747,-0.005441968,0.03777271,0.03689809,0.07562007,0.022917435,-0.0037032096,-0.04808929,-0.022899615,0.082251385,0.012377634,0.089340106,-0.019320343,0.007932502,-0.056412864,-0.0046414207,-0.078269556,0.012905537,-0.06761621,-0.037098434,0.02436952,-0.0048760083,0.03083398,0.033989344,-0.005484849,0.007947317,0.0070814723,0.008083,-0.014875704,0.045597136,0.010036774,-0.057891037,-0.0028714826,0.0733254,0.05339136,0.022234682,0.033512723,0.039169427,0.027718073,2.820068e-05,-0.020948913,-0.065722965,-0.07813486,-5.7746838e-05,0.06818011,-0.068437904,0.05089575,0.08251647,0.05573131,0.06362854,0.0766519,-0.035817463,0.023418775,0.046092268,-0.0048873452,0.017448604,-0.052913107,-0.021690805,-0.050421145,-0.0075755287,-0.026001329,-0.051902045,-0.009690633,-0.02464409,0.015772356,-0.11253668,0.004336485,0.009398572,0.022607023,0.09402443,-0.050169896,0.07072616,-0.0142382085,0.061430186,-0.058337804,0.060593355,0.043810405,-3.674427e-08,0.02943551,-0.08349924,0.06175825,-0.04996653,0.047887847,0.056515403,0.013055198,-0.033785842,0.033852577,-0.07955281,-0.012879272,0.04395612,0.07271307,-0.015490005,0.08197686,0.021671077,-0.034182675,-0.032371327,-0.013144916,-0.116861336,-0.079486854,-0.038244445,-0.013451328,0.082863666,0.028228374,0.014303951,0.04169645,0.09919359,-0.025515767,-0.00019911537,0.02212076,0.04939487,-0.052372754,-0.05886214,-0.053179063,0.045276683,-0.049997125,-0.07197426,-0.01948739,0.05657652,0.053758867,0.004117519,-0.048815522,0.028595695,0.030724227,0.077992514,-0.026348324,0.0093824165,-0.0059605325,-0.02951935,0.033849742,-0.00782252,-0.05059531,0.010423893,-0.034164198,0.043135177,-0.067669645,-0.011437418,-0.02346546,0.00018233989,0.06878554,0.0009807479,0.17563319,-0.019296492 +6.3.2.57,"Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.",384,1.0,-0.09626907,-0.08640208,-0.11272375,-0.012399885,0.037864465,-0.04138429,-0.055057418,0.024698278,0.046893828,-0.0098121585,0.036228538,-0.028266963,-0.053192027,0.034851167,-0.078877,-0.011800112,-0.10443001,-0.006883073,0.0471648,-0.022367649,0.0037889443,0.084210165,-0.04110557,-0.0045295823,-0.007403409,0.02166725,0.06491954,-0.0459396,0.020199772,-0.0054060942,-0.012649932,-0.037695628,-0.013097907,-0.07270391,0.08619525,0.09392054,-0.037957873,-0.015517195,-0.0040192185,-0.033214856,0.014968891,-0.025229303,0.07436381,-0.036991023,-0.02758207,-0.015638981,0.025032945,0.03149934,0.033145092,-0.021072842,0.0013685668,-0.05511549,-0.079559855,-0.014634719,0.040914763,-0.014919441,-0.14857061,-0.034559317,-0.00016163827,0.038265083,0.026822286,0.026326925,0.012501138,-0.03574952,0.07236892,-0.0007208585,0.062306885,-0.058318388,0.012602817,-0.0016604041,-0.050858002,-0.083818495,-0.041672483,0.013933087,-0.023952018,0.05342047,0.048905604,-0.01807767,-0.010224071,-0.028324962,0.017832749,0.054006595,0.07995042,0.120392285,0.06609047,0.04217829,0.016859692,0.046077654,0.021879433,0.055028576,0.016623324,0.0063896594,0.025181143,-0.030731475,-0.03415152,-0.0014508198,-0.11659755,0.028372414,-0.0024199083,0.014002977,-0.04438286,0.06494404,0.009875251,-0.03875508,-0.019788783,-0.00040619288,-0.026130712,0.079363205,0.055641484,0.053330913,0.07482929,0.08373085,-0.045349088,0.007862125,0.04766707,0.078148395,-0.0073807365,-0.08108225,-0.017726537,-0.02500241,-0.01166188,-0.005703112,-0.024141634,0.06144129,-0.082909405,0.030411046,-0.093467325,2.9896208e-33,-0.019356154,0.029408552,0.07295986,-0.020121079,-0.032005075,0.0050456747,-0.0899299,0.014705148,0.001406892,-0.045919973,-0.06385191,-0.059350263,0.0066212397,-0.0153212715,0.06493298,-0.083698265,0.005234314,0.0597326,0.052186076,-0.01956808,-0.0319267,0.10418471,-0.0262965,-0.0140789,0.04444275,0.09115625,-0.021776177,-0.05204385,0.10708478,-0.036748543,0.03942778,-0.09319242,-0.04220805,-0.029017918,0.094755016,0.012150199,0.0213198,-0.031964853,0.023517644,0.062068895,-0.055143707,0.022924924,-0.031821378,0.007600814,0.0551746,-0.051923193,-0.011170326,0.0587732,-0.024252897,-0.008217068,0.025604734,0.0054322034,0.036904767,-0.010738903,-0.07360062,0.031219942,-0.024764258,-0.013600964,0.03303126,0.04239249,0.018588547,-0.015306843,-0.016955279,0.0027060844,-0.020826297,0.035671208,-0.028061014,-0.11792425,0.052741904,0.04155285,-0.036876995,0.0024977387,0.058117494,0.053953417,0.0013889887,-0.048109397,-0.057287734,0.03844064,0.08910701,0.052014105,-0.008679795,0.072458975,-0.046679214,-0.054836407,-0.010664264,-0.05055021,-0.084371515,-0.0477989,-0.0016471748,0.022802489,0.0203157,-0.070551105,-0.07618658,0.02580373,-0.0051452694,-4.8480293e-33,0.028651234,-0.14466868,-0.0143682435,-0.10276521,-0.08475714,0.076978184,0.058767047,-0.05859553,-0.009848088,-0.004008683,0.0943573,0.01006974,-0.02245238,-0.056811273,-0.016151126,-0.08317211,-0.05822631,0.06156283,0.019962821,-0.021848872,0.03984883,0.112578146,0.091429345,0.027020657,0.018830204,0.06102407,-0.03446075,0.104598194,0.060279768,0.04635229,-0.004606811,0.011432498,-0.052762795,-0.035641294,-0.052943196,0.083934255,-0.02785978,0.023482986,0.0021230245,-0.014220721,0.048875004,0.06164035,0.03506926,0.0984814,0.005969816,0.08280932,-0.08557682,0.11942806,-0.00041723985,-0.09206923,0.044324815,0.05627973,-0.03311113,-0.006654369,0.012787223,0.021869332,0.03462398,-0.0372614,-0.017623983,0.0017369165,-0.05635789,-0.09389802,0.032591842,-0.015823836,0.038416088,0.005427676,0.029647272,0.031936724,0.047321375,-0.03614923,0.07547969,0.003091928,0.044068743,0.0025799396,-0.03375806,-0.055200513,0.019744234,-0.08287244,0.07129109,-0.12448985,-0.03754867,0.007253044,0.035866357,-0.00038667806,0.008448517,-0.07349321,0.096213534,0.08522952,0.03534757,0.011054275,0.0012482814,-0.002345635,-0.022679266,0.061986897,-0.04875143,-4.0504187e-08,0.024929034,-0.07563064,0.04246805,-0.08535599,-0.0072881607,0.065109104,-0.052217502,-0.06644309,0.04541086,-0.024823911,-0.011654392,-0.010233755,-0.042702075,-0.039408583,-0.014597992,0.027536778,0.001969485,-0.012909583,-0.028972963,-0.0840482,-0.078380525,0.0027825157,-0.123057276,0.0035318956,-0.017846985,-0.034387738,-0.0010363592,0.07845599,-0.04985653,0.061019573,-0.017043041,0.023596,-0.013823761,0.0008653144,-0.023276845,0.01719607,0.008338043,-0.025207512,-0.029286038,-0.035378955,-0.060038365,0.0016790114,-0.008778233,0.011367412,0.004405762,0.025728865,0.024525579,0.016227366,-0.017120056,0.08703129,0.018699972,-0.062813945,0.023966443,-0.03416131,-0.114219174,-0.024732599,0.029452715,-0.13138045,-0.028538773,0.0036193964,0.039356384,0.021272838,0.14977406,0.085114114 +7.3.2.7,"This bacterial transporter does not belong to the ABC superfamily, and instead is a member of its own family, referred to as the Ars family. The enzyme usually contains two subunits where one (with 12 membrane-spanning segments) forms the 'channel' part and the other (occurring in pairs peripherally to the membrane) contains the ATP-binding site. It forms an arsenite efflux pump that removes arsenite from the cytoplasm, and can also remove antimonite anions.",384,1.0,-0.02007649,-0.02455735,-0.05782439,-0.01276806,0.0012849863,-0.044901192,0.09613731,-0.00352045,0.08138131,-0.08033076,0.029008865,-0.040056303,-0.0040053646,0.072158106,-0.0591483,-0.06202625,-0.13696517,-0.050141383,-0.031368043,-0.048234772,0.032541845,0.056515723,-0.02124242,-0.0094316695,-0.0501753,0.027225746,0.07805824,-0.011542187,-0.04740724,-0.08234217,-0.050181758,-0.0492535,0.027889382,-0.027019775,0.027403362,0.077924795,-0.042769477,0.0018338163,0.04151748,-0.004916278,0.08104754,0.0070671537,0.04108172,0.037167847,-0.10844126,0.055299025,0.009133459,0.00855215,0.039747003,0.029346166,-0.045992054,-0.029516663,-0.04363564,0.13968983,0.041607775,0.06347224,-0.08746938,-0.00025766328,-0.05665925,-0.0102046365,0.067231454,0.050018884,0.035891347,0.043247283,-0.016368277,-0.046981025,0.009345278,-0.031696156,0.005089345,-0.02905039,-0.05971566,-0.08987888,-0.03097328,0.041039858,0.047622055,0.013896905,0.050714362,-0.049873278,0.013399022,-0.023195952,-0.029977657,0.0023425235,0.026128322,0.04162777,-0.0034914021,0.009371779,0.0107121905,-0.039701335,-0.01177656,0.03593839,-0.003010601,-0.025547605,0.040883746,-0.09640896,-0.0042162975,-0.042172443,0.00911771,0.047880284,-0.01587321,-0.017887864,0.009272773,0.03791164,0.0080709,-0.036888495,-0.06816237,-0.040547274,-0.003925314,0.072698176,0.0076860185,-0.0038707634,-0.015474065,0.028989092,0.044607982,-0.06066738,0.0155278575,0.05487025,0.024932913,0.031754863,-0.026913358,0.052405953,-0.041645832,-0.06956234,0.06203745,0.07481238,-0.039995123,0.023347385,-0.17939456,-1.8355172e-33,-0.054472286,0.027334016,-0.016734136,-0.047954272,-0.0029252039,-0.040485773,-0.041838948,0.023188766,-0.01204302,-0.030816376,-0.10173662,-0.09169463,-0.0034045295,0.014409095,-0.046246395,-0.046651505,-0.109781705,0.04830634,0.028051674,-0.035919428,0.026685145,0.08738635,-0.03510177,-0.09892584,0.03841131,0.0068284594,-0.00019193294,0.00959479,0.04698867,-0.005055594,0.0018705216,-0.009255959,-0.13857356,-0.01946627,0.033200428,-0.017843382,-0.024415117,0.011501672,0.04901493,0.020512898,-0.03034273,0.0006115879,0.0032311066,0.043348595,0.081853874,-0.068478,-0.07203925,0.021463599,0.06646637,-0.03175328,0.054007858,-0.09308955,0.09056001,-0.047965597,-0.04102149,-0.028206376,-0.026992094,0.057219286,-0.030293185,0.0669379,0.10651646,0.061449677,-0.06886313,0.066626355,0.020393565,0.045175377,0.002624814,-0.0253403,0.02639078,0.043389294,-0.06378554,0.007349721,0.09481042,0.023123495,0.00087398186,0.02151393,-0.07765107,-0.006591918,0.033684928,0.027493043,-0.07321197,-0.07303258,0.09272413,0.027620437,-0.018362299,-0.051047154,0.0034733396,-0.020133846,-0.0146371545,-0.011656667,0.11644482,-0.0064753084,-0.13606231,0.07712904,-0.0019066938,-8.208911e-34,0.060912177,-0.05710423,0.119088404,-0.118672535,-0.07292861,0.029308483,0.08360968,0.017420175,0.027915493,0.016106332,0.054602627,0.051401045,0.012149526,-0.10229449,0.050144363,-0.033897065,0.028270444,0.010892735,-0.025703749,0.0014523591,-0.025126932,0.039061505,-0.0107384715,0.006571463,-0.07135217,-0.010851888,0.0061564525,0.07042994,0.045642585,0.031730626,-0.013300383,0.043023404,0.03546806,-0.12896392,-0.09843011,0.014086136,-0.045454353,0.00021059178,-0.050782572,-0.0479381,0.07662588,0.037524533,-0.00064806466,0.09886291,0.0033101854,0.105040364,-0.001609501,0.03224782,0.022103075,0.0023758048,0.010161759,-0.038606413,0.021706415,0.014198402,0.07346774,0.05494127,0.024892928,0.009389673,-0.01890288,-0.042526864,-0.043355137,-0.034280196,0.07171335,-0.05995365,0.034525085,-0.0045312294,-0.038349222,-0.012672369,-0.005131286,-0.0025786816,0.047084898,-0.005206807,-0.045786764,-0.045923516,-0.009236655,0.060870778,-0.051190324,-0.05636585,-0.028855503,0.0012756955,-0.05354201,0.044189878,-0.0437119,-0.0074701463,0.08868785,-0.03085207,0.062750176,0.062412184,-0.027253635,0.054227144,0.030337371,-0.013476526,0.014050195,0.038791165,-0.027159594,-4.0845546e-08,0.004413763,-0.034153376,0.08129513,-0.099045455,-0.038187582,0.05563969,-0.0327753,0.07805027,0.07907361,-0.0060752165,-0.023962017,0.086688034,0.014341385,0.045878224,0.04878031,0.027962629,-0.04581183,0.03465402,0.0037463484,-0.06673287,-0.076379895,-0.0545866,-0.0055402853,0.040783755,0.023053242,-0.038412925,0.024160597,0.023849567,-0.04991607,-0.080422245,-0.01950178,0.03521931,0.013224152,0.062153473,-0.07785514,0.064225964,-0.038050782,-0.02852272,-0.07231301,0.07291423,0.0794316,-0.061640237,-0.055629086,0.016744196,0.03871715,0.046862725,-0.08295689,0.056368887,-0.04351282,-0.014548941,0.02873789,0.014020077,-0.04092454,-0.039925702,-0.047910098,-0.031162225,-0.076058544,-0.026524061,0.034320585,0.047891926,0.0652222,0.048223663,0.13253844,-0.052435163 +7.4.2.10,"A prokaryotic ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli is a heterotrimeric complex that interacts with an extracytoplasmic substrate binding protein to mediate the uptake of glutathione.",384,1.0,-0.07610117,-0.05353918,-0.07426918,-0.030564163,-0.0797153,-0.002558381,0.04343272,0.10360466,0.043351743,-0.088729,0.048554216,-0.046585873,-0.026678776,0.10746484,0.011323417,-0.06705728,-0.03374132,0.020378204,0.0046851686,-0.07192647,0.009506532,0.09294207,-0.055034656,0.011283069,-0.092680514,0.028426098,0.017006,-0.019068163,-0.017340131,-0.008905612,-0.08933961,-0.050416052,0.027498689,0.027029106,0.0330002,0.09238843,-0.04807721,-0.043345757,0.08459802,-0.007112197,0.10376433,0.011842887,0.07483233,0.046386044,-0.100484885,-0.022938104,0.040233493,0.041261114,0.017342007,-0.025478153,-0.01204203,-0.04109605,-0.0548787,0.059923407,0.021266576,0.034009643,0.019590737,-0.04490075,-0.013588592,-0.024622781,0.0047424543,0.0025425758,0.08700029,0.04298419,0.030066773,-0.08009702,-0.017695187,0.03925515,-0.023671081,-0.0024936784,-0.063025974,-0.04857794,-0.060757473,0.06824978,0.012906315,-0.03850955,-0.06329854,0.014753991,-0.006078469,0.002281511,0.04351391,-0.04034094,0.0023155692,0.050247505,0.025766524,-0.02862416,0.017618513,0.02329825,0.026060488,0.0013319758,-0.027012547,-0.06393664,0.015692454,-0.03641009,-0.14233685,0.0016453232,-0.037080485,0.002687868,0.008412998,0.003896929,0.043712802,0.053359687,0.06717251,0.0027928285,-0.011875962,-0.02267351,0.020041952,0.08197937,-0.03850395,0.010456522,-0.03278379,-0.011831799,0.006174372,-0.06476066,-0.029572327,0.06724168,0.0019661782,0.030486222,-0.028766038,0.024496237,-0.03999733,-0.060562193,0.015066684,-0.02460739,-0.0030597057,0.0073821717,-0.08395835,9.171091e-34,-0.062038567,-0.034119442,0.03566067,0.002463498,0.025173195,-0.021277798,-0.012431814,-0.063389376,-0.0069391932,-0.07014699,-0.030713309,0.0011337381,0.008324939,0.080601804,-0.017596874,0.004156359,-0.12780455,0.07189854,0.11377576,-0.00613913,0.081325434,0.03497021,0.020618634,-0.04803437,0.06454036,0.021277381,-0.0351037,0.006812965,0.048142068,-0.011276849,0.012068842,-0.04319606,-0.111197196,-0.00038183524,0.06659881,-0.07418581,-0.02362293,-0.049991485,0.04340617,-0.04212126,-0.095835716,-0.031440746,-0.06414543,0.055665504,0.055636678,-0.03849697,-0.02148139,0.04882209,-0.036667064,0.054734524,0.041656278,-0.15363279,0.06912735,-0.080325186,-0.035138037,-0.014106327,-0.012936143,0.031523146,-0.034310132,0.07578706,0.061214548,0.15293968,-0.056263737,0.023587044,0.039148785,0.066517845,-0.08957696,-0.074961424,0.06340242,0.13136418,0.0054477165,0.0032527312,0.032854132,0.06827056,0.02836353,0.026370786,-0.096015595,-0.05499599,-0.02681341,0.06331366,-0.04650453,-0.056336656,0.02143336,-0.020761881,-0.08778585,-0.015703782,-0.01693809,-0.035053138,0.014843397,-0.022532098,0.14298381,0.06536856,-0.050007023,0.097837776,0.0090736365,-2.6229052e-33,0.09557554,-0.037319973,0.09388427,-0.06480718,-0.051935542,0.003990831,-0.0050032334,-0.025960248,0.041132938,0.00036582164,-0.011786853,0.05321704,-0.011817408,-0.033875175,0.028061923,-0.082960196,-0.057857398,0.0064187543,-0.045002386,-0.02963817,0.010672468,-0.021566091,0.02057407,0.010312397,-0.065032735,0.0069692815,-0.014576449,0.07299347,0.005960354,0.030662876,-0.046159953,-0.012840975,-0.018819895,-0.05537773,-0.06457338,0.05881343,0.025308566,0.04687854,0.005837719,-0.04374662,0.016879959,0.07255138,0.002737499,0.062147956,-0.010623906,0.111970246,-0.015970185,0.06603274,0.017870806,-0.070906326,-0.012828917,-0.029300602,-0.014177257,-0.019917501,0.044721395,0.058731318,-0.031904235,-0.032584883,0.011583447,-0.035805896,-0.028120393,-0.099702895,0.034280658,-0.0053452915,-0.0071517825,-0.045395304,0.051526472,-0.08377793,-0.023144018,0.085054986,0.09866439,0.0073547456,-0.019570166,0.023906656,0.033282463,0.0063772146,-0.026171098,-0.028240737,-0.05135505,0.00048886926,-0.0030906778,0.014664417,-0.048900273,-0.022758268,0.10668077,-0.018697549,-0.01263873,0.057649408,0.010013524,0.04018037,0.005218912,0.04898442,0.0096473405,0.055056944,-0.05273979,-3.6860083e-08,0.008624917,-0.03525537,0.01747919,-0.074544966,0.005266162,0.04128672,-0.04983805,-0.009104304,0.12140511,0.06691577,0.015850428,0.11671693,0.0038186992,0.025426965,0.039281342,0.07350001,-0.023108115,-0.006216569,0.024102034,-0.046689797,-0.0132586,-0.057317104,-0.05113325,0.040337123,0.05355494,-0.052190393,0.0211467,0.060446277,-0.02936049,-0.044111792,0.027614532,0.014603692,-0.007191618,0.014435092,-0.03757738,0.028872052,-0.037117276,-0.00035437988,-0.067240894,0.024012404,0.055897616,-0.0095353015,-0.10911471,0.01118102,0.05463737,0.07525602,-0.053367905,0.06648122,-0.07858568,-0.001879824,0.039168973,-0.009096227,0.0011984562,0.011790518,-0.11312261,0.014525521,-0.06928171,-0.053703263,-0.057327032,0.030391047,0.06670679,0.02587233,0.14253014,-0.0045386367 +7.4.2.11,"ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and functions to import methionine. The enzyme from Escherichia coli K-12 mediates the high affinity transport of both L- and D-methionine, as well as methionine-S-oxide and N-acetyl-DL-methionine.",384,1.0,-0.09075707,-0.06801787,-0.02699257,-0.012332501,-0.068099245,0.019264357,0.023680925,0.09727132,0.05393444,-0.061469223,-0.0024118691,-0.059453968,-0.024104869,0.11356752,-0.022900276,-0.04506516,-0.05213181,0.034085896,0.0020825001,0.0031310427,0.014989285,0.06814247,-0.06636354,-0.0048620123,-0.010463304,-0.013765861,0.014489635,0.026808897,-0.021324536,-0.020752866,-0.06808765,-0.0017870832,0.026229588,0.008577848,0.042499304,0.095129214,-0.027188586,-0.0002645343,0.09145254,0.0066098175,0.08113299,0.033508055,0.13956696,0.048955046,-0.06123421,-0.035693858,-0.01689032,0.061560955,0.008162874,-0.08446587,-0.052911434,-0.016960226,-0.0627449,0.08540021,0.026122646,0.06878989,-0.022811325,-0.009302555,0.007990355,-0.037523605,0.016897539,-0.022123333,0.11596932,0.040436678,0.029974112,-0.09261016,-0.05617855,0.03085247,0.07918076,-0.019641723,-0.07457631,-0.040464483,-0.019840423,0.037041288,0.021604082,-0.07778733,-0.037020113,0.0047320975,-0.011411899,-0.053370997,0.027411083,-0.020268153,-0.04666441,0.039535552,0.05059841,-0.024113217,-0.020964958,-0.020264149,0.027729463,-0.0027389023,-0.051804353,-0.06769782,0.0074199797,-0.07890613,-0.1337595,-0.056101955,0.015544936,0.06502006,-0.037149664,0.029648514,0.03470937,0.059161182,-0.0064129764,-0.009205037,-0.04648727,-0.057347152,0.05763173,0.026287995,-0.033244442,-0.021801017,0.033908658,0.0046609445,0.027220387,-0.058532167,-0.031467263,0.06599286,0.002547623,-0.031330626,-0.008265785,0.023547724,-0.064282484,-0.12394915,0.043485597,-0.050027072,0.014164506,0.033932403,-0.048675492,4.520012e-34,-0.056527015,-0.047313556,0.015372998,0.014416705,0.013554545,-0.07512299,-0.03184258,-0.04440677,-0.022107607,-0.110515036,-0.040420897,-0.0019261128,-0.005354667,0.08061243,-0.06563506,0.004300605,-0.08504872,0.02719629,0.08003036,-0.012289253,0.062349185,-0.013850936,-0.013504769,-0.018584171,0.0794651,-0.0029442518,-0.05185532,0.015783194,0.059270173,0.017906727,-0.012211264,0.020962352,-0.09460696,0.0424545,0.020660486,-0.015991908,-0.09964927,-0.032021236,0.085323334,-0.054942783,-0.02992719,-0.014202751,-0.043681722,0.060382348,0.038613837,0.027687773,-0.040702607,0.057221744,-0.037129335,0.017529184,0.06444921,-0.14679356,0.09978076,-0.09550759,-0.04580563,0.0012802714,-0.020459337,-0.022721883,-0.016966155,0.11902189,0.033214036,0.080341086,-0.05783686,0.071149446,0.026303867,0.01997785,-0.04175187,-0.065566264,0.056460474,0.118433975,0.0034864154,0.050077807,0.03166691,0.085691676,0.021329748,0.009035265,-0.062820114,-0.019700792,0.032702636,0.025597012,0.03075251,-0.09492877,0.020916497,-0.024625555,-0.07823864,-0.018891254,-0.011325905,-0.06354013,0.040787403,-0.011071697,0.0805971,0.018296925,-0.049051505,0.08976167,0.023222761,-1.6296769e-33,0.052097358,-0.0066489237,0.08071866,-0.06406485,-0.061519805,0.03062472,-0.005034983,-0.016970707,0.049925722,-0.023141194,0.05568069,0.02541969,-0.013619545,-0.038344037,0.029030908,-0.04998537,-0.043089915,0.019046143,-0.008821812,-0.042560678,0.030713856,-0.04749288,-0.028594915,-0.007125862,-0.034762993,0.010018671,-0.043500073,0.07810123,-0.020447142,0.06857454,-0.016041834,0.014836253,-0.018498091,-0.05514102,-0.10631704,0.076765016,-0.0054212175,0.03855822,-0.0024907368,-0.05359384,0.053156123,0.07082076,0.004903789,0.047131605,0.015719876,0.09416486,0.022326758,0.003961488,0.026993405,-0.06357958,0.024425087,-0.09342152,0.00552549,-0.02409427,-0.0033130816,0.14472194,-0.011650469,0.008055538,0.000918343,-0.07532812,-0.03756683,-0.11483225,0.022824012,-0.007985203,-0.00026552434,-0.017961979,0.058015246,-0.048106816,-0.040305138,0.0536879,0.050585113,0.04253587,0.039914634,0.02510515,-0.030422833,-0.00025833855,-0.052669883,-0.0028842108,-0.04651295,-0.00053768913,-0.060788404,0.02019805,-0.038315833,0.037023924,0.07874363,0.02227606,0.0050067105,0.042000484,0.02444475,0.08778041,-0.049163036,0.041072164,0.004422657,0.03782556,-0.023717387,-3.8641524e-08,0.062953174,-0.08626764,0.0009369358,-0.06717578,0.030836355,0.0738028,-0.085109785,0.013350316,0.11613349,0.03631117,-0.01628816,0.13880244,0.007176973,0.030668834,0.030271271,0.0795571,-0.026749903,-0.010542419,-0.025041835,-0.020658163,-0.009642988,-0.012007132,0.023368072,0.044050526,0.0583508,-0.064415105,-0.0022806954,0.07371165,-0.03087368,-0.08419096,0.030063976,-0.00086614524,-0.040130064,0.0048940745,-0.06619476,0.042753346,-0.061131418,-0.06354699,-0.056721803,0.042201668,0.0767447,-0.014363324,-0.08614514,0.035598505,0.06261015,0.019119665,-0.07700948,0.022754114,-0.074847795,0.017533315,0.042272113,0.005800499,0.029134383,-0.0145071605,-0.07951134,0.00028571032,-0.05185955,-0.0065372265,-0.0182709,0.010917428,0.021884937,0.037192836,0.13709086,0.013742975 +7.4.2.12,"ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.",384,1.0,-0.067939356,-0.055292506,-0.012519783,-0.032165505,-0.09246772,0.02866053,0.036054015,0.058157835,0.047676947,-0.10619374,0.03318795,-0.014859888,0.020943075,0.0965301,-0.043386463,-0.043082625,-0.09830807,0.0653893,-0.012843092,-0.017549807,0.020395411,0.01984682,-0.034089286,0.020845361,-0.051873673,-0.027857328,0.037326474,0.020990334,-0.012396891,-0.017259212,-0.09215974,-0.011303338,-0.029955367,0.00063436746,0.05169719,0.052863322,-0.037833944,-0.015315695,0.09753433,0.016609143,0.08505757,0.012369208,0.075517766,0.080542594,-0.100968845,-0.02636552,0.037934124,0.021145301,-0.01703697,-0.06303015,-0.020826666,-0.01797437,-0.038152933,0.07958668,0.015252255,0.042302314,-0.06796281,-0.027807921,-0.0033332082,-0.062136333,0.023843545,0.02490065,0.07307966,0.03841217,0.0098286,-0.05840928,-0.058165357,0.052754678,0.036325123,-0.054038532,-0.1006299,-0.10204695,-0.04908489,0.12144244,0.03616914,-0.026306534,-0.03138661,-0.0059666466,-0.075552106,-0.019150544,0.019503582,-0.04656139,-0.049668573,0.06476439,0.060917888,-0.04023658,0.02163322,0.06331885,-0.014418989,0.02047447,0.010550814,-0.022491122,0.02490047,-0.077489614,-0.0821913,-0.030753938,-0.0050375527,0.061579876,0.017472435,-0.013764472,0.033561897,0.05940937,0.052867632,-0.017931115,-0.012193268,-0.017132973,0.01779741,0.03370913,0.0022436036,-0.04695638,-0.032990936,0.0013453505,-0.0053343363,-0.08442032,-0.034395784,0.103187636,0.0143825635,0.040037822,-0.023741037,0.021077259,-0.0481809,-0.11446497,0.01671027,-0.013761847,-0.0173854,0.044337057,-0.112270154,1.9347316e-33,-0.07675941,-0.025781875,0.037027888,-0.01330694,-0.005206539,-0.046827406,0.0059861736,-0.04266096,-0.0060786107,-0.07742194,-0.06653679,-0.016052552,-0.008188533,0.053324226,-0.05913429,0.017107813,-0.11636621,0.035364665,0.07253865,-0.01846509,0.0678254,0.03614427,-0.015665393,-0.037210464,0.08366942,0.007517253,-0.027839117,0.02436751,0.057021327,-0.013822805,0.0306455,-0.048143614,-0.09701178,0.012955825,0.025382528,-0.076097004,-0.045121793,-0.025567643,0.03369974,-0.025646623,-0.08696429,-0.026941612,-0.014851678,0.07416389,0.051236704,0.017923629,-0.05437301,0.06273482,-0.03748655,0.0064765913,0.07681001,-0.11465138,0.050052688,-0.082544304,-0.01118743,0.0064064073,-0.016138375,0.013060695,-0.022878021,0.06857332,0.071587436,0.120829195,-0.040378667,0.034417156,0.05284738,0.075151846,-0.07420784,-0.071967736,0.0030787962,0.14086834,-0.06294054,0.04551277,0.016852254,0.058885273,0.08613223,-0.0072267856,-0.108671084,-0.06632762,0.042023357,0.019173758,-0.05994883,-0.11337267,0.03715892,0.008820705,-0.06440013,-0.057017837,-0.046891883,-0.02463513,0.046042275,-0.011156243,0.11732641,0.034328897,-0.073231444,0.10983875,-0.0018477257,-3.5631085e-33,0.07542152,-0.027779652,0.09445225,-0.045681577,-0.03385569,0.0070912223,-0.0021835794,-0.0061473134,0.04109155,0.006413742,0.04553639,0.0363352,-0.009763596,-0.0069719227,0.020396834,-0.023556875,-0.047376167,0.03626307,-0.020111406,-0.0004068823,-0.039587043,-0.021130312,-0.014869576,0.020129185,-0.06410778,0.019660238,-0.010153904,0.0773455,0.005936428,0.07129882,-0.0145676695,0.014923589,0.018106222,-0.083191484,-0.08779943,0.07938351,0.0010177394,0.0022573075,0.010578678,-0.017548364,0.017774954,0.03250763,-0.024703043,0.04939148,-0.0073483326,0.07262483,0.017348185,-0.0019939903,0.02660264,-0.029457483,0.04167017,0.016778516,0.015135923,-0.015681036,0.04255774,0.12065224,-0.020180183,0.00437616,0.026084702,-0.042319473,-0.038043503,-0.106414035,0.03796728,-0.021752317,-0.0029240549,-0.023854563,0.01951817,-0.018383672,-0.06308758,0.06057954,0.07005709,0.010749467,-0.0006987467,0.023239238,8.463836e-05,0.015378723,-0.024782425,-0.04069639,-0.042385127,0.019198725,-0.03592126,0.013695038,-0.02769731,0.0046691154,0.07070116,0.017397499,-0.012532364,0.051238425,0.022105023,0.03937896,0.04337669,0.01906243,0.0013143885,0.07320777,-0.044836503,-3.970305e-08,0.030405719,-0.07172791,-0.01314044,-0.078625716,0.016632868,0.061253067,-0.08801205,0.03486637,0.08950839,0.031058664,0.00020792747,0.111173585,-0.011211886,0.04849473,0.05769068,0.047066532,-0.06368825,0.008041972,0.002830506,-0.015189118,-0.027574882,-0.022057204,-0.038557675,0.04079201,0.06367957,-0.065783896,0.01930998,0.09938278,-0.031705383,-0.0739419,0.04847426,-0.004200657,-0.04012622,0.019459983,-0.075247735,0.08742388,-0.07441726,-0.04570045,-0.04539793,0.046929877,0.04246589,-0.072842024,-0.113346845,0.0035243875,0.08584937,0.019307425,-0.06518238,0.021626653,-0.059791777,0.009961338,0.053573072,-0.018096454,0.036575936,-0.029768929,-0.014437486,0.018539615,-0.05802102,-0.013702963,-0.02810669,-0.017310282,0.0039402004,0.015098199,0.18363863,-0.010870258 +7.5.2.7,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of D-ribose.",384,0.99999994,-0.048619512,-0.08752622,-0.010611462,-0.049415432,-0.105462976,0.0033564004,0.043082934,0.075670205,0.07381995,-0.04699101,0.0033706627,-0.02874375,0.016790621,0.12108105,-0.011682423,-0.06257046,-0.054206047,0.036324896,0.023667114,-0.010585919,0.024092624,0.12234509,-0.027449021,0.011854208,-0.06428671,0.008559862,0.02053458,-0.03308714,-0.038469862,-0.020701714,-0.07722185,-0.012218218,0.034828387,0.032326777,0.010662706,0.08177084,-0.0032150643,0.006388073,0.08047217,0.030067353,0.08970262,-0.0010832193,0.10954234,0.062192574,-0.12542018,-0.010420574,0.025714796,0.07438067,0.014808712,-0.016630622,-0.006723884,-0.023685569,-0.053330295,0.021922072,0.023572378,0.07334538,0.032798197,-0.008536313,-0.011705776,-0.0791976,0.0018240039,0.0041216835,0.08391032,0.089020886,0.03157228,-0.08356393,-0.040768214,0.06277462,0.016466592,-0.012772911,-0.07285712,-0.07065979,-0.06568204,0.053738706,0.047126982,-0.05840025,-0.007130473,-0.0064123813,-0.019779427,-0.04613553,-0.009597513,-0.02878264,-0.0024506294,0.033525318,0.014534778,0.004537006,0.0039048512,-0.00023492918,0.016943539,0.0047348673,-0.025083354,-0.053805258,0.036624294,-0.046159573,-0.11688948,-0.04601512,-0.0016989214,0.04278794,0.008038662,-0.029887773,0.045081936,0.068199486,0.04279652,-0.010598796,0.0132144755,-0.0036392447,0.006118265,0.038420744,-0.030098023,-0.012000429,0.0016119175,0.014250334,0.0019513567,-0.05287905,-0.0048588514,0.06747326,0.0091924295,-0.011797249,-0.02899435,-0.0071981363,-0.09135481,-0.104933895,0.0169488,-0.026521727,-0.016457884,0.030894486,-0.072812974,-9.566267e-34,-0.086303204,-0.07452899,0.026494306,-0.0032500117,-0.014037628,-0.051751707,-0.04011962,-0.053313028,-0.029506529,-0.056271873,-0.07123772,-0.03674977,0.023709742,0.10366951,-0.012863537,-0.027747668,-0.10399709,0.07386925,0.06894832,-0.008511712,0.05072502,0.06984358,0.037931684,-0.038848404,0.097511366,0.0027840168,-0.014456397,-0.01844044,0.09638427,-0.024680803,0.017386954,-0.047797136,-0.08153729,-0.0019974469,0.027228814,-0.04355405,-0.048978057,0.011571047,0.05674636,-0.017634388,-0.06612445,-0.050201014,-0.06481778,0.03923878,0.047014643,-0.029486964,-0.007395504,0.05610367,-0.06563377,0.03582398,0.10730908,-0.16052295,0.0670329,-0.0859047,-0.01942272,-0.016560163,-0.027904203,0.04054271,-0.026909785,0.07126601,0.06420209,0.11355559,-0.041438207,0.0410611,0.05001967,0.033468336,-0.040328562,-0.14123546,0.047498416,0.09567416,-0.023644317,0.016782375,0.061403014,0.018537195,0.041351058,0.01998043,-0.1096814,-0.0584934,0.008210817,0.039340157,-0.04473634,-0.07857931,0.011855468,-0.023382248,-0.06838757,-0.024726346,-0.004089945,-0.07726297,0.0018359559,-0.022171393,0.12050933,0.04028783,-0.10503835,0.106249094,0.06327736,-8.097093e-34,0.089519955,-0.039566994,0.10391201,-0.028971756,-0.056499436,-0.007325031,0.014650889,-0.04138127,0.032198004,-0.05788997,0.012080094,0.06389305,-0.018886631,-0.022485772,0.0032708799,-0.061023436,-0.048748143,-0.00279684,-0.044552192,-0.020095006,0.009782691,-0.031641144,-0.022591628,0.015737306,-0.08202218,-0.00047352814,-0.023566298,0.06081531,0.011946276,0.0063301413,-0.0085033085,0.03848809,0.02712952,-0.041743018,-0.07385191,0.06497185,-0.010262803,0.05048912,-0.023164298,-0.02381109,-0.015718425,0.097259186,0.0013951054,0.051304445,0.0053308215,0.09101786,0.002128473,0.027446233,0.00045144686,-0.02354176,0.009166387,-0.041785926,0.03792774,0.025204312,0.04910983,0.106298536,-0.017601278,0.02175399,0.07592475,-0.05859167,-0.055914696,-0.07051366,0.08247737,-0.013775677,0.009578697,-0.03190539,0.02346081,-0.06261566,-0.050092883,0.040009584,0.08960534,0.039200976,-0.007869754,0.009669894,0.045590475,-0.0048444713,-0.039844207,-0.048406307,-0.082495846,0.02587488,-0.083488174,0.060815413,-0.048214108,0.022993451,0.08919453,-0.013231745,-0.0035166955,0.023937441,0.0015133746,0.053572718,0.021887593,0.014529804,0.033783328,0.04157017,-0.018745862,-3.3116525e-08,0.01295211,-0.008063747,-0.010552633,-0.08820611,0.0005586917,0.04211103,-0.049036093,0.040268846,0.10319765,0.03174073,0.013391577,0.10793086,-0.0057515176,0.021167526,0.08286274,0.052274987,-0.055618796,-0.028702453,-0.014755625,-0.049801618,-0.0029827687,-0.02856295,-0.05537373,0.05998796,0.053660255,-0.04231857,0.013137578,0.05275146,-0.00036995596,-0.056424342,0.062190294,0.04753108,-0.0037763177,-0.010037284,-0.039129965,0.036577377,-0.05093507,-0.0010374119,-0.04998768,0.08815205,0.04494667,-0.06910329,-0.07002305,-0.013854233,0.027153704,0.042286377,-0.061784703,0.09103735,-0.0529671,-0.00056831643,0.03884008,0.02287613,-0.012576228,-0.030862587,-0.08212465,0.012979845,-0.08625043,-0.03462231,-0.009491337,0.031165184,0.017638665,0.0061504575,0.099141866,-0.028641695 +7.5.2.8,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of D-allose, which can be used by the bacterium as a sole carbon source.",384,1.0,-0.07811785,-0.054634452,-0.043336835,-0.027587878,-0.071335174,0.019423766,0.04237104,0.08997403,0.07543055,-0.043597035,0.022282371,-0.053248476,-0.049172863,0.092707604,0.017484311,-0.05666214,-0.030461267,0.0410414,0.036868412,-0.04445754,0.02852753,0.09891119,-0.03362027,0.016138766,-0.076978154,0.018250754,-0.0030765503,-0.04137455,-0.013083276,-0.04800973,-0.09807662,-0.027702436,0.02268975,0.044026505,0.015794355,0.083238244,-0.021903884,0.0055575073,0.088884674,0.015753426,0.10166812,-0.009671792,0.11094308,0.08295629,-0.13803953,-0.033715133,0.022741372,0.06942152,0.01753155,-0.039719153,-0.008864909,-0.03614155,-0.052149344,0.021614935,0.01451981,0.060887482,0.0169746,-0.009008125,0.0002531886,-0.08150265,0.01554025,0.014231603,0.10203423,0.08462355,0.032673914,-0.097519994,-0.011322799,0.01606861,0.0035052844,-0.011431448,-0.08254667,-0.06664484,-0.03689235,0.05732278,0.042785496,-0.032591768,-0.035942227,0.0143061,-0.008026142,0.0068048714,0.012109361,-0.022285864,-0.004082914,0.038131483,0.016477166,0.017830573,-0.0047898255,-0.0027440065,0.0113996435,0.019012785,-0.03566399,-0.06024015,0.02729916,-0.039579883,-0.12501708,-0.02193508,0.019959709,0.03255123,0.043925796,-0.03805547,0.041141026,0.05866681,0.032686137,-0.0030358816,-0.01223812,-0.017428983,0.006392304,0.051656988,-0.0019394659,-0.017808478,-0.013036171,0.035075102,0.017896703,-0.026791219,-0.038762763,0.04088326,0.006810586,-0.028647395,-0.032650664,0.014126293,-0.09502867,-0.11365678,0.008021756,-0.008554231,-0.022240475,0.028676718,-0.061513852,7.2583505e-35,-0.06440964,-0.05083445,0.01957089,-0.009581895,-0.021422055,-0.03962848,-0.025537426,-0.05147407,-0.056101445,-0.0324772,-0.055527013,-0.011855008,0.0277159,0.12605737,-0.031895418,-0.013411267,-0.09951,0.048620023,0.09715075,-0.041503154,0.040190697,0.045865536,0.03610571,-0.040723555,0.10664789,0.018799989,-0.01752665,0.027430585,0.074158244,-0.022589719,0.030333778,-0.036008418,-0.094463184,-0.0042835246,0.06675659,-0.06262855,-0.052577455,0.029843522,0.03319176,-0.027667351,-0.058057398,-0.020243367,-0.060093313,0.021557359,0.029545864,-0.023648776,-0.04748894,0.061438628,-0.033939928,0.045243062,0.053090733,-0.15755789,0.0547329,-0.08162427,-0.02025876,-0.01251329,-0.0070973095,0.033512287,-0.05932905,0.07473613,0.0613819,0.1240292,-0.05579094,0.030418674,0.04408169,0.060231898,-0.058861792,-0.106781825,0.034873657,0.08155806,-0.010089266,0.019561896,0.045286685,0.026033798,0.031163357,0.017939823,-0.11895227,-0.037540168,0.0185142,0.056809306,-0.030819248,-0.079063,0.021333482,-0.03424158,-0.080382,-0.02311048,-0.023845803,-0.060409848,0.022700867,-0.0011394884,0.115152285,0.019494008,-0.065385446,0.08592152,0.03590119,-1.8691578e-33,0.08791844,-0.017749587,0.09961243,-0.03262267,-0.053144727,0.00026189262,-0.0020521283,-0.042887002,0.038808584,-0.026375175,0.026561668,0.079140484,-0.007403145,-0.013114694,0.023013294,-0.051634684,-0.06343204,-0.03335568,-0.051284,-0.035499774,-0.0015990983,-0.0322842,-0.0048668156,0.010246184,-0.046063934,-0.004675933,-0.03601593,0.06642665,0.009613748,0.010252903,-0.016248176,0.024683613,0.014483,-0.046358444,-0.09673335,0.03158738,-0.015540015,0.09410226,0.0013060673,-0.036105767,0.000662256,0.037581105,-0.011400481,0.04253462,0.0017075073,0.11018287,-0.022460056,0.02391271,0.011770688,0.0048478893,0.016850714,-0.03794009,0.019963248,0.0050607505,0.06358588,0.10342255,0.0101607805,0.0033905532,0.054377846,-0.092532605,-0.03874167,-0.072704494,0.07210825,-0.03579666,0.011824816,-0.045193512,0.0069856425,-0.04472693,-0.05580562,0.045300405,0.08914408,0.041334487,-0.012801096,0.012633803,0.01242781,0.007623232,-0.028461907,-0.06942643,-0.0657284,0.03460907,-0.07910849,0.060058855,-0.04947096,0.015415642,0.10322862,0.013072613,0.014738295,0.004980155,0.0041085333,0.05868241,0.010501551,0.016007226,0.026131736,0.044840798,-0.020261511,-3.8243197e-08,-0.02568939,-0.046703026,0.00438107,-0.090570584,-0.011083822,0.05061418,-0.0075042043,0.061915975,0.12351906,0.040265966,-0.0012040165,0.124408156,0.020315278,0.039859787,0.08795774,0.0392325,-0.056228835,-0.033897933,0.00091491995,-0.069884725,-0.04022833,-0.069942325,-0.031350803,0.05340382,0.09121385,-0.06708195,0.029317396,0.0518606,-0.029290166,-0.043059297,0.020004485,0.030421957,-0.019784711,0.020448774,-0.040851347,0.02642431,-0.05648175,-0.036385715,-0.059826165,0.09661051,0.064096,-0.028886717,-0.093846545,0.00013363617,0.028864764,0.05898953,-0.06199871,0.10041023,-0.0754548,0.014511096,0.022880986,-0.030223979,-0.022728968,-0.019040734,-0.07811048,-0.0027834955,-0.062824324,-0.023399701,-0.008527902,0.04884178,0.04098119,0.0027600955,0.12070001,-0.043683294 +7.5.2.9,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichai coli interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of D-galactofuranose. The periplasmic binding protein exhibits selective binding of D-galactofuranose over D-galactopyranose.",384,1.0,-0.023327705,-0.1135517,-0.011210269,-0.033713337,-0.05938452,-0.00013088132,0.052327473,0.0703324,0.08158641,-0.0607241,0.0064569623,-0.024167309,-0.021236649,0.1164428,-0.008047419,-0.06481499,0.028803777,0.07592737,0.031634472,0.008771174,0.09926173,0.03880047,-0.06487851,-0.006342502,-0.012095095,0.0072353445,0.033421103,-0.073220484,-0.053243972,-0.060048778,-0.07517768,-0.073983386,0.049927544,0.032638274,-0.015831757,0.067496926,0.00064277224,-0.031540453,0.045981113,-0.03654901,0.072842635,0.01665447,0.10094651,0.031062372,-0.092488974,-0.044576168,-0.015510077,0.1208943,0.03967824,-0.066449925,0.009204816,-0.091927096,-0.046297774,0.027936565,0.031199453,0.11776791,0.030780764,-0.06592877,0.017229447,-0.04822158,0.025503414,0.031720787,0.104070075,0.071922496,0.0156121,-0.10660805,-0.0037548447,0.029619271,-0.0043538334,-0.045736693,-0.04506803,-0.0022831343,-0.044498317,0.0032876977,0.05624009,0.00044983052,-0.04363576,0.026628416,0.025684802,-0.037813395,0.028148925,-0.024579171,-0.004311002,0.03728756,0.016588384,-0.020558119,0.044401567,-0.0012461873,0.015545059,-0.015472714,-0.015614946,-0.09870112,-0.020902092,-0.046662915,-0.11606879,-0.014756653,0.008274034,-0.029726006,0.006277564,-0.03780983,0.012429323,0.04914938,0.05815656,0.025196472,-0.02441944,0.0057004583,-0.0019726052,0.043012727,-0.05124907,-0.027067875,0.02117276,0.0002285841,0.069350004,-0.014177802,-0.045798965,0.06269209,-0.008318891,-0.0052771354,-0.04231916,0.013943,-0.071460254,-0.09546958,0.013899285,-0.016547514,0.038123086,0.061693918,-0.014776948,3.8008486e-33,-0.01678419,-0.064250976,0.028559012,-0.003269853,0.03740559,-0.03689549,-0.050159782,-0.05645179,0.008488439,-0.06322892,-0.07741145,-0.022097126,0.034034766,0.053221103,-0.01940063,0.07606938,-0.06341536,0.048724238,0.06919137,-0.021359509,0.04630837,0.06955531,0.036226857,-0.06896472,0.07612943,0.024793332,-0.070182204,0.010711469,0.10322742,0.023707496,-0.0043630344,-0.054412976,-0.094859876,0.03403725,0.07408084,0.007424318,-0.038536333,-0.030861534,0.046561018,-0.08288475,-0.03342304,-0.051082164,-0.089666024,0.039298244,0.015533902,-0.045468487,0.0057858527,0.037223496,-0.050614003,0.04361196,0.05587203,-0.15220366,0.045238554,-0.054749634,-0.024720347,-0.017878048,-0.027968165,0.030965973,-0.001005036,0.087487094,0.03462613,0.10141874,-0.041715257,0.043532204,0.08277502,0.04456111,-0.05603089,-0.067666225,0.0031935105,0.06468583,-0.025028026,-0.042759396,0.02365963,0.037976593,0.015211466,-0.022647452,-0.03729354,-0.01763078,0.04345767,0.026755804,-0.016777942,-0.02466744,0.006524371,-0.031377267,-0.047330067,-0.0016796442,-0.024507271,-0.04682479,0.045599334,0.028015206,0.09058429,0.033454567,-0.06445951,0.10011186,0.0371048,-4.6762025e-33,0.07330327,-0.044398695,0.13664736,-0.04191243,-0.03709312,0.04436382,-0.029033637,0.009761473,0.0598557,-0.08900822,-0.008119349,0.0095179975,-0.08459474,-0.056832936,-0.009541192,-0.036390547,-0.0059518223,0.0068769623,-0.094308764,-0.029317826,-0.044234306,-0.014650416,0.013968047,0.07141379,-0.08493968,-0.030621031,0.009653251,0.048431847,-0.037296657,0.03725489,0.012951733,0.016525453,-0.02141569,-0.047442984,-0.10104933,0.037292942,-0.051034186,0.077750385,0.025182486,0.0012822631,0.0011942008,0.102512866,0.009954005,0.016288614,0.053639658,0.08091507,-0.014270294,0.024303678,0.058032896,-0.048540693,0.007663842,-0.11319572,0.036518104,0.014206387,0.03199556,0.09154284,0.022262732,0.045516834,0.06453997,-0.043038517,-0.051437162,-0.07453876,0.058612756,-0.06391893,0.03011626,-0.07022392,0.02327135,-0.0012043314,-0.0102806715,0.0031677645,0.057438683,0.007931625,-0.0008892707,0.048160616,0.04806522,0.008516777,-0.06877343,-0.043339036,-0.026949791,0.012299698,-5.5749542e-06,0.11451338,-0.06577567,-0.04010051,0.103287056,0.04052984,0.036307734,0.049568515,0.015033737,0.04230895,-0.012205703,0.058972996,0.023729132,0.024790226,0.053645767,-3.9294378e-08,0.06457465,-0.01197655,0.013590704,-0.09098311,-0.0514122,0.050670866,-0.024439164,0.038370155,0.072149344,0.029386697,0.004207943,0.16464128,-0.009511637,0.035745192,0.007059244,0.05798514,-0.015866822,-0.030107154,-0.015273067,-0.027953314,-0.0143218255,-0.044554237,-0.045079034,-0.010565223,0.065524496,-0.05561368,0.030452449,0.044044126,-0.033550493,-0.05365503,0.06546027,-0.0017466875,-0.032180686,0.017631438,-0.038035188,0.02144505,-0.04457651,-0.020252997,0.0010251424,0.04840568,0.038676564,-0.021175474,-0.011358574,-0.040667407,-0.037946247,0.062634006,-0.07667264,0.10612245,-0.0998459,0.055573184,-0.008873513,-0.08089445,-0.04422587,-0.073498964,-0.0855224,-0.07231498,-0.044587683,-0.044953402,-0.026071817,-0.019280452,0.020003345,-0.033778768,0.08025985,0.006152543 +7.5.2.10,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of D-xylose.",384,0.99999994,-0.07121931,-0.088874206,-0.01571075,-0.050311502,-0.0895925,-0.0046964176,0.0822456,0.07495787,0.05949706,-0.059952367,0.03835558,-0.05459333,-0.0039987573,0.122902066,0.014798777,-0.033005025,-0.055276338,0.022036022,0.013874588,-0.007971802,0.038565982,0.10385927,-0.027047059,0.00579537,-0.061451983,-0.00071775547,0.012333181,-0.06050184,-0.030221872,-0.015899338,-0.08560691,-0.018955808,0.027330268,0.016608322,0.035059337,0.08015205,0.0010406568,-0.0063179485,0.07655107,-0.0038917577,0.10657069,-0.022123523,0.09021325,0.062127277,-0.17056727,-0.018106325,0.02826787,0.059970897,-0.0012137025,-0.01605738,-0.004557729,-0.034791633,-0.065218374,0.048003636,0.035787698,0.06404619,0.0032119646,0.016631838,-0.031270746,-0.0784582,0.016656656,0.044725027,0.11009462,0.09951599,0.00659017,-0.09324358,-0.041730244,0.043372694,0.004586074,-0.009195315,-0.08565004,-0.068157285,-0.04995092,0.04279733,0.047564477,-0.05137387,0.0040695206,-0.0067668012,-0.024516432,-0.03410595,0.011844774,-0.012494776,0.004845233,0.061405305,0.022671385,-0.044848327,0.010536522,0.00765439,0.0009064953,0.017161967,-0.017640017,-0.062168766,0.013471019,-0.043575913,-0.107393086,-0.044228293,0.037869558,0.016526101,0.0327751,-0.022618385,0.023468755,0.060653377,0.060755678,-0.0042831893,-0.008677169,-0.030291343,-0.010333201,0.042646036,-0.04067554,-0.028398221,-0.011842097,-0.012152669,0.031610686,-0.0286118,-0.031672567,0.053156167,-0.0036341234,0.010473597,-0.036651593,-0.006440356,-0.07261382,-0.11377461,0.008028589,-0.018386697,0.0015140584,0.026054634,-0.072560266,-7.5482e-34,-0.07762115,-0.0387894,-0.014911151,-0.03269541,-0.004314445,-0.07230994,0.011348058,-0.013286628,-0.046592873,-0.030973056,-0.018920355,-0.036794737,0.021654679,0.12475593,-0.024316067,-0.024145423,-0.11099235,0.08007887,0.08807475,-0.0049990225,0.060612448,0.042236544,0.028027171,-0.0732184,0.084570654,0.014183446,-0.039641436,0.013814919,0.06836108,-0.017841762,0.010644545,-0.06715528,-0.062515214,0.017493082,0.049050443,-0.023354422,-0.035378397,-0.013816249,0.019751437,-0.036011074,-0.08513363,-0.04671193,-0.0603376,0.017364213,0.042470697,-0.024631022,-0.057089545,0.031844474,-0.04129702,0.02954762,0.09066563,-0.16460483,0.07282441,-0.039814558,-0.008877757,-0.0074358587,-0.032372523,0.052078832,-0.062459406,0.04993129,0.057922203,0.10701874,-0.050128467,0.026406746,0.07452868,0.046286665,-0.043217864,-0.13671815,0.024679413,0.10077283,-0.049875204,-0.009434298,0.060680743,0.019040497,0.06776758,0.025517894,-0.1130873,-0.015849989,0.020897381,0.042350452,-0.013914919,-0.08248786,0.036665905,-0.029808227,-0.10166274,-0.033593677,-0.009927659,-0.029511483,0.0036592693,-0.01545829,0.11117458,0.014105009,-0.0789142,0.10036726,0.042455304,-1.0306688e-33,0.07786875,-0.007822794,0.1135234,-0.024910225,-0.04690949,0.0094097275,0.023418255,-0.0235356,0.023485593,-0.046344884,0.016566522,0.07065462,-0.03938253,-0.0014751564,0.022738343,-0.03306236,-0.023997853,-0.009657851,-0.043978278,-0.047163468,0.0017904182,-0.0051302603,-0.015745062,0.017953072,-0.06755002,-0.00973092,-0.012939869,0.07384905,0.010541464,-0.0025808848,-0.02949485,0.025221072,0.030786421,-0.05653196,-0.06775458,0.032966185,-0.016416678,0.05927644,-0.040271908,0.0019725696,0.026389662,0.07787077,0.010502985,0.06783538,0.009685607,0.09888149,-0.011552486,0.03783435,0.038335286,0.0095305,-0.0021449768,-0.023024453,0.0049155527,0.0005139327,0.040802725,0.12477418,-0.01360286,0.0047789677,0.055845983,-0.06674267,-0.06572675,-0.08420434,0.099950485,-0.005081412,0.009818603,-0.056080855,0.01985158,-0.050281502,-0.05381541,0.04606205,0.106415965,0.026429836,-0.022067081,0.010645278,0.0067553488,0.0032140245,-0.038873486,-0.064625114,-0.044596866,0.025539316,-0.033423413,0.05236171,-0.03554196,0.0054564006,0.09942188,0.03134964,-0.016810425,0.030916687,0.009503116,0.018052189,0.031351667,0.009673767,0.014882703,0.030131863,0.005547204,-3.348732e-08,0.009688818,-0.037973795,-0.015773404,-0.061926305,0.00083362183,0.044192757,-0.033812467,0.0399842,0.118271485,0.05228631,0.016490625,0.11081103,-0.0017015357,0.04017738,0.06157938,0.027445346,-0.02530361,-0.015366225,-0.024132824,-0.06864763,-0.013193268,-0.054194897,-0.04238853,0.036851645,0.07470317,-0.06855746,0.022277366,0.064215615,-0.025245758,-0.052540626,0.024678107,0.046232104,-0.028962225,0.030180816,-0.028485877,0.049010497,-0.07523174,-0.03923383,-0.05977845,0.074286535,0.04464924,-0.060403407,-0.060672294,0.003305679,0.05870111,0.06315122,-0.05720928,0.07652437,-0.05891291,-0.01843366,0.026854021,-0.011397092,-0.015137525,-0.054613117,-0.06873145,0.019786166,-0.08024481,0.0075678816,-0.024143567,0.027926587,0.010356482,0.029605344,0.13179661,-0.053415146 +7.5.2.11,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme, best characterized from Escherichia coli where it interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of D-galactose and methyl-beta-D-galactoside.",384,0.99999994,-0.06071453,-0.09791754,-0.022011813,-0.0357043,-0.092897624,-0.00029815122,0.041650124,0.077258706,0.077758834,-0.07217588,0.021057306,-0.022770913,-0.01989722,0.1457503,-0.019718794,-0.05296671,-0.025540996,0.049889587,0.062501445,-0.0010890841,0.04569507,0.084714174,-0.05105833,0.01716142,-0.03660962,0.036551543,0.030166978,-0.053283803,-0.04925696,-0.03040547,-0.09144993,-0.037098225,0.044633668,0.030929679,0.012089542,0.089756906,-0.0043476527,-0.022711318,0.092314035,-0.007884857,0.08723644,0.004367102,0.10700738,0.042300172,-0.1160524,-0.024551898,0.03373837,0.05660152,0.009575709,-0.05121044,-0.0039784387,-0.044209003,-0.04458461,0.03844869,0.02709067,0.06864473,0.023402108,-0.04390834,0.0054439274,-0.05682229,0.017212069,0.02173906,0.10942892,0.08592726,0.012582065,-0.07789375,-0.027254622,0.031397656,0.010496177,-0.03536114,-0.08937385,-0.05117486,-0.057192706,0.048574895,0.052100398,-0.032453157,-0.022360744,0.009962056,0.0009413412,-0.024631744,0.005861293,-0.030656278,-0.027026486,0.041550733,0.027305352,-0.035711084,0.03638712,0.023281796,0.017522017,0.0039007098,-0.0373088,-0.04424997,0.008831156,-0.056346845,-0.120916165,-0.02997515,-0.009959469,-0.0093160765,0.030492544,-0.031840835,0.046000846,0.063371174,0.055965893,0.00034786222,0.016077913,-0.010787039,0.009977629,0.04882219,-0.009154193,-0.0044191545,-0.0062965206,0.027539805,0.022344142,-0.046452653,-0.035326805,0.054567724,-0.021460341,0.0061007775,-0.032454487,0.0209278,-0.067027725,-0.1147396,0.0013803073,-0.036541954,0.0073599,0.040856734,-0.06561296,9.848978e-35,-0.06900072,-0.040140722,0.015026214,-0.011206224,0.012518757,-0.04499678,-0.03290555,-0.05577985,-0.00043304433,-0.057273317,-0.037515964,-0.030785004,0.00984518,0.11148432,-0.002945975,0.020435896,-0.09191057,0.061913252,0.091107056,-0.02465563,0.04037005,0.06474865,0.028247014,-0.07462573,0.11658661,-0.0121689895,-0.045561507,0.026243173,0.0812577,-0.016291345,0.02256233,-0.05198534,-0.083550125,-0.023126883,0.060857102,-0.042954296,-0.05787041,-0.003105414,0.04336579,-0.0531459,-0.07254382,-0.03917524,-0.070229895,0.061597757,0.052646205,-0.026219,-0.029870395,0.057988375,-0.046590492,0.047736492,0.063523084,-0.15365376,0.038480494,-0.08888019,-0.009969854,-0.0020606052,-0.018463273,0.05616488,-0.048172977,0.078467526,0.06693198,0.12835573,-0.060153272,0.025887948,0.063079566,0.03744881,-0.041582596,-0.106987365,0.03009521,0.10111487,-0.01770741,0.009673365,0.039752282,0.037011724,0.024169007,-0.0018965242,-0.07214816,-0.04764908,0.052940894,0.015003142,-0.044961866,-0.045865253,0.026769703,-0.03607995,-0.07000935,-0.024765765,-0.02498798,-0.046641648,0.008655823,-0.0186938,0.11320802,0.03485642,-0.06770101,0.110703975,0.042637303,-2.2039742e-33,0.09213231,-0.03424862,0.11847352,-0.046314474,-0.064081185,0.011411577,-0.002346756,-0.0028770156,0.04117848,-0.040490646,-0.008898479,0.06175079,-0.030066013,-0.034411874,0.009472645,-0.05445865,-0.03231919,-0.0065340754,-0.064496145,-0.011551308,-0.0040193195,0.013056367,0.010827309,0.036947563,-0.09354416,-0.01953044,-0.011852272,0.063986845,-0.005579015,0.000586878,-0.006900045,0.026680734,0.017091949,-0.079526,-0.08811236,0.037326064,-0.018379359,0.052875474,-0.0030379521,-0.014994514,0.022996517,0.08847518,-0.006957207,0.037890688,0.0007445452,0.07639286,0.00034922204,0.041001584,0.0440962,-0.030621888,-0.030341243,-0.061352342,0.030979142,0.00020664305,0.049529698,0.07482751,-0.021111006,0.007625018,0.05725586,-0.07718982,-0.06744943,-0.083793856,0.09415541,-0.025003083,-0.0033746317,-0.06259867,0.007199758,-0.052088168,-0.04012566,0.04131707,0.06945181,0.034021165,-0.020881694,0.030951085,0.019906081,-0.0014713688,-0.047301386,-0.06760679,-0.040811904,0.025798986,-0.01111272,0.083960675,-0.07337262,-0.0028979795,0.07875916,0.022018092,0.023086194,0.035349626,0.019139849,0.048516188,0.019849485,0.028191764,0.016543224,0.030526517,-0.01899262,-3.8625174e-08,0.018940978,-0.038233813,0.020605054,-0.09283618,-0.017846907,0.06419618,-0.057856657,0.029161194,0.10123884,0.03344279,-0.003924137,0.13571213,-0.034364305,0.03726924,0.034038,0.056506813,-0.05659951,-0.02059457,-0.0031658302,-0.045820154,-0.029694043,-0.03493069,-0.039746728,0.051972836,0.07672859,-0.061519004,0.03770388,0.06294956,-0.04515742,-0.042889163,0.034572702,0.026574358,-0.023675162,0.001876004,-0.046391662,0.028421313,-0.05370553,-0.016034871,-0.040543888,0.08795586,0.078784056,-0.04530399,-0.06114292,-0.016978195,0.02180106,0.05771334,-0.07593993,0.08934121,-0.08270164,-0.0014691713,0.02619748,-0.041655254,-0.04604384,-0.03139577,-0.07895129,-0.0037692175,-0.07885755,-0.03336132,-0.030474756,0.015304868,0.049869597,0.010361706,0.10966108,-0.014292075 +7.5.2.12,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high-affinity uptake of L-arabinose.",384,0.99999994,-0.07211022,-0.07911319,-0.02392916,-0.036154013,-0.07851802,0.029053155,0.05504616,0.060947675,0.06515795,-0.067548014,0.040605538,-0.05561531,0.0039910325,0.0860581,0.0070423773,-0.04026012,-0.048196033,0.03672874,0.0042522396,-0.056895148,0.0099006,0.08415673,-0.047674187,0.020443648,-0.059756387,0.01759388,0.0031105694,-0.039616536,-0.0356641,-0.02558449,-0.078529425,0.0031128759,0.03433421,0.016859706,0.007783177,0.10275402,-0.021345342,-0.01447533,0.10576514,0.0027028578,0.13410911,-0.0211255,0.11713002,0.04084183,-0.14079706,-0.018398587,0.05423631,0.038394853,0.027564203,-0.019843863,-0.016004156,-0.037388716,-0.04360673,0.029167473,-0.016957246,0.04042464,0.006794638,0.013194781,-0.007413334,-0.05199415,-0.017325478,0.016155396,0.0925559,0.09639371,-0.0067442497,-0.071363956,-0.009597928,0.020793807,-0.0019526832,0.008375731,-0.059841473,-0.046679873,-0.07063769,0.061688386,0.039645385,-0.033196334,-0.03881092,0.007612497,-0.052800387,-0.014297256,-0.0005791521,-0.031157937,0.006280638,0.026656106,0.01745176,-0.05499747,0.01961395,0.018764006,0.024947023,0.021743722,-0.007669103,-0.050854255,0.022792615,-0.03130659,-0.09155574,-0.041688807,-0.010749836,0.022827597,0.0030789934,-0.025151776,0.03947365,0.042644717,0.045116067,-0.0051035825,0.014598413,-0.016764581,-0.012240175,0.021772249,-0.019443372,-0.02704798,-0.026606336,0.012033496,0.017963022,-0.05752662,-0.03213568,0.05662067,0.006623829,-0.019248076,-0.031191144,0.018400569,-0.061607573,-0.106036484,0.013258329,-0.045435153,-0.014752108,0.020730942,-0.10280325,-1.2449921e-33,-0.09297413,-0.07491035,0.015326761,-0.015599043,-0.014276358,-0.055025816,-0.018249024,-0.03464162,-0.036149926,-0.08759975,-0.008844525,-0.0034914236,0.036786832,0.13204128,-0.024182329,-0.000831678,-0.09308256,0.043662302,0.079133116,-0.021296864,0.035878263,0.035044022,0.034174446,-0.04449196,0.08740632,0.014486805,0.013195648,-0.03515144,0.070968926,-0.004303818,0.008570945,-0.048049062,-0.10512473,-0.017362792,0.03270598,-0.04304922,-0.044755246,-0.003030218,0.020639632,-0.032034446,-0.06150843,-0.04481129,-0.0553331,0.05852151,0.06278617,-0.023715526,-0.024718372,0.05241974,-0.03169368,0.05438419,0.07439603,-0.14288113,0.05851075,-0.06456692,-0.009024383,0.0033713335,-0.024615744,0.05879976,-0.086844735,0.08341427,0.080979034,0.124727055,-0.026597414,0.037602425,0.036138833,0.0627753,-0.060007337,-0.12160529,0.039477803,0.10228765,-0.0039272336,-0.0048584184,0.06732602,0.076442234,0.03751701,0.026333448,-0.08770349,-0.060894646,0.022323295,0.048104856,-0.03801478,-0.07091745,0.052253272,-0.0029647294,-0.12689444,-0.032749522,0.009806965,-0.024265632,-0.0038439939,-0.0503649,0.13540566,0.043606002,-0.07094887,0.11269991,0.02796817,-7.497443e-34,0.102595836,-0.021992104,0.09842267,-0.04398907,-0.056819662,-0.023916768,0.04739091,-0.0061273933,0.029556815,-0.014840205,0.0057153855,0.038529966,-0.010960262,-0.035711553,0.03935099,-0.101877995,-0.030582758,-0.011903714,-0.052675433,-0.027978696,0.0020401052,-0.015158886,0.033367176,0.0077455146,-0.07127427,-0.019433327,-0.029901586,0.102526344,-0.02359134,0.023176987,-0.035795283,0.035694677,-0.0010074561,-0.05140854,-0.062280744,0.05740985,-0.008056589,0.029285358,-0.013979558,-0.02495547,0.012054309,0.07676475,0.010095204,0.03366739,-0.003956339,0.09387441,0.00393988,0.04837015,0.017841568,-0.054155987,-0.025595471,-0.0058956137,0.003276104,0.013744918,0.050697517,0.09609575,-0.045538343,0.0019228834,0.047148615,-0.077295646,-0.04731534,-0.06491689,0.094826296,-0.018370943,-0.013289953,-0.028761601,0.04428144,-0.08059088,-0.031797793,0.06773893,0.111893356,0.046724055,-0.010069999,0.032255556,0.032095935,0.041814096,-0.04633037,-0.06519802,-0.08019325,-0.007840308,-0.045295376,0.027759176,-0.07130827,-0.008516014,0.12398342,0.0108954515,-0.014460954,0.01926766,0.020830302,0.028509364,0.040127825,-0.012705741,0.005433177,0.055748206,-0.04804862,-3.3676436e-08,0.016474135,-0.040074844,0.0069498196,-0.06184379,-0.0058671446,0.06733109,-0.052725084,0.03683667,0.09327518,0.0439633,0.018400745,0.07546133,-0.002420195,0.06320684,0.052252032,0.043192096,-0.041203316,0.009577541,-6.26689e-05,-0.05417508,-0.027058177,-0.04228401,-0.039108127,0.043820217,0.080467805,-0.033507023,0.005062344,0.06691864,-0.009891945,-0.071482725,0.05718205,0.014475896,-0.015921608,0.003627935,-0.030257668,0.040133752,-0.07441251,-0.007760026,-0.061834183,0.08362494,0.057794727,-0.038318112,-0.08617247,-0.0040373276,0.06362468,0.04504285,-0.05799164,0.06967455,-0.06972288,-0.0035559146,0.0685844,-0.019933242,-0.005942816,0.0017733534,-0.053965244,-0.01952243,-0.07771382,-0.030153755,-0.013268707,0.0533211,0.003370001,0.03213199,0.10373711,-0.03397949 +7.5.2.13,"ATP-binding cassette (ABC) type transporter with a 10-transmembrane-spanning (TMD) subunit and a single nucleotide binding domain. The enzyme from the archaeon Sulfolobus acidocaldarius interacts with an extracytoplasmic sugar-binding protein and mediates the uptake of of D-xylose and L-arabinose (cf. EC 7.5.2.10, ABC-type D-xylose transporter and EC 7.5.2.12, ABC-type L-arabinose transporter). 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A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of the signalling molecule (2R,4S)-2-methyl-2,3,3,4-tetrahydoxytetrahydrofuran (also known as autoinducer-2).",384,1.0000001,-0.0790543,-0.06226245,-0.06715823,-0.05497566,-0.076047465,-0.0024125369,0.039589826,0.0939986,0.058466963,-0.0768183,0.05025516,-0.09112266,-0.00625038,0.11915826,-0.05464153,-0.047193367,-0.09739986,-0.02730244,0.051242035,-0.06559289,-0.01999196,0.097553834,-0.05082064,0.003277893,-0.06020717,0.022348434,-0.009946604,-0.031352576,-0.014513257,-0.010582693,-0.06753314,0.00013948955,0.007962054,-0.00075320073,0.018674,0.05302153,-0.040148534,0.034057237,0.08857635,-0.006441922,0.11759453,-0.040819447,0.09860303,0.041988686,-0.12836723,-0.005144445,0.03688338,0.03793723,0.037389945,-0.024601404,-0.050201222,0.0024446428,-0.033183675,0.07644744,0.021463567,0.044774063,-0.006825718,0.0040959683,-0.0075424816,-0.035975255,0.034536317,-0.008929245,0.076346464,0.08625708,0.008457211,-0.057848122,-0.04093268,0.0194504,-0.0022619118,0.026907494,-0.06470024,-0.07111438,-0.05882775,0.043440085,0.058201812,-0.02865283,-0.055437308,-0.0067381714,-0.013076647,-0.013528395,-0.0385217,-0.051829237,0.015479134,0.063764095,-0.0034050248,-0.0535285,0.00095004385,-0.0125696,0.024498675,0.0656539,-0.013781095,-0.04951464,0.007490549,-0.0466089,-0.1280657,-0.0017251855,0.02386262,-0.006875319,0.041454896,-0.018744292,0.017561413,0.04205912,0.01757525,-0.008226242,0.008527623,-0.03240472,-0.0030238198,0.033944212,0.034234703,-0.0032186173,-0.03991279,0.021465227,0.014679444,-0.07007196,-0.020215569,0.07713698,-0.024839222,-0.004389806,-0.0006552045,0.0147068,-0.07215505,-0.10027043,-0.0008012734,-0.044717938,0.049331583,-0.001023845,-0.08914103,-1.0481399e-33,-0.07028411,-0.045325413,0.008873127,-0.018895563,0.012654073,-0.06115462,-0.026395595,-0.024255967,-0.0066554653,-0.054193903,-0.030682579,-0.0480805,0.02141491,0.14214961,-0.035289403,-0.039325695,-0.10828577,0.049485087,0.09524862,-0.03253938,0.065526865,0.08308959,0.021444354,-0.07374138,0.080820456,0.011547524,-0.0008723176,0.02503238,0.07689892,0.0020684823,0.021077594,-0.06064897,-0.093421616,-0.016085548,0.063232385,-0.04807202,-0.046765823,-0.005752838,0.026129065,-0.031792447,-0.026810447,-0.032162953,-0.050341655,0.02810584,0.06997958,-0.038292952,-0.017712431,0.064308636,-0.030999802,0.03496432,0.07828385,-0.14984858,0.060290936,-0.065939315,-0.013862188,0.0115473885,-0.030622207,0.05031256,-0.030583523,0.05598913,0.031634234,0.09684823,-0.03273894,0.024576202,0.070049055,0.035881765,0.0023431822,-0.13446513,0.03329662,0.08817044,-0.0049869637,0.03642157,0.08469016,0.05038239,0.066559725,0.03301637,-0.08666525,-0.065766685,0.026484674,0.051484164,-0.04990722,-0.058399092,0.08730349,-0.01604309,-0.06906609,-0.040450543,-0.0005168132,-0.039082028,0.022188794,-0.021704607,0.13008635,0.0066354843,-0.10179567,0.10879393,0.025993373,-1.48295e-33,0.08255181,-0.030663071,0.12736477,-0.031563092,-0.04103482,0.02215299,0.026197342,0.04992976,0.026640544,-0.034336135,0.052086517,0.074854374,0.001879905,-0.011539839,0.03225949,-0.067084625,-0.02101472,-0.0036126226,-0.048120104,-0.016522016,0.003122402,-0.024046626,-0.014818116,0.035146337,-0.08088182,0.0048414557,-0.0049773776,0.05532889,-0.055065446,0.05424175,-0.009956852,0.015156916,-0.009129975,-0.056213405,-0.047887843,0.06992424,-0.01746461,0.016355228,-0.057135,0.0054641273,0.06538301,0.054705963,0.0020459718,0.056305252,-0.023486648,0.05562857,-0.035220265,0.07136536,0.011044465,-0.039765973,-0.02407454,-0.011937207,0.045269523,0.0022473698,0.08266882,0.07659281,0.0022703845,-0.018572234,0.050820384,-0.044017583,-0.06337482,-0.08312688,0.082814865,-0.022836234,0.0017483117,-0.057296526,-0.02098308,-0.0697695,-0.036006697,0.06772539,0.10043883,0.023449248,-0.00509477,0.00041498558,0.037095413,0.01093508,-0.027924016,-0.06325885,-0.066665426,0.0051600775,-0.046551373,0.052834027,-0.03771806,-0.012412125,0.017644618,-0.004919465,-0.002488348,0.030765194,-0.017777763,0.03142275,0.03268348,0.04388649,-0.015770797,0.050986566,-0.039242204,-3.952327e-08,0.0072676637,-0.037637062,0.03776871,-0.06862275,-0.0026314522,0.023764515,-0.0631787,0.05977216,0.091583274,0.056021463,0.043363117,0.07330695,-0.00073718233,0.033993166,0.043405414,0.027491745,-0.008703458,-0.022985533,-0.02000862,-0.091430105,-0.058618594,-0.036189497,-0.03234304,-0.0031812857,0.08205085,-0.021504331,0.011478079,0.065746926,-0.022943253,-0.07273108,0.036875732,0.043541797,-0.044471327,0.013867125,-0.06784768,0.051883366,-0.051288422,-0.07447608,-0.08462275,0.06107529,0.047775008,0.013107465,-0.08812889,0.008063558,0.012536129,0.04598584,-0.06003927,0.07552467,-0.077479765,-0.06291439,0.035156637,-0.02050872,0.003916359,-0.034296323,-0.048627265,-0.0018736058,-0.080240875,-0.0108474875,-0.043178957,0.051676314,4.0229115e-05,0.04744396,0.09903569,0.0017001858 +1.3.1.120,"The enzyme, characterized from the bacterium Streptomyces collinus, is involved in a pathway that transforms shikimate to cyclohexane-1-carbonyl-CoA by a series of dehydration and double-bond reduction steps. Most of the steps in this process occur with the carboxylic acid activated as a coenzyme A thioester. The enzyme catalyses three steps in this pathway, also acting on (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA and (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA.",384,1.0,-0.05665497,-0.030803375,-0.10454067,0.02010819,0.027617207,0.045289017,-0.11883445,0.015394072,0.071674034,-0.017197978,0.009731907,-0.06418753,0.033852555,0.033834532,-0.050838076,0.0049807923,-0.09582448,0.013596673,0.007692647,-0.056456406,0.067761265,0.004041137,-0.029067375,0.023302324,0.06513075,-0.03373985,0.030756244,-0.036594797,-0.074865565,-0.07631039,0.0733562,-0.020246137,0.03894074,-0.030685151,0.08903873,0.118462384,-0.02979627,-0.08222944,0.07688331,0.02810681,-0.027993433,-0.028243214,-0.04573251,-0.022760358,-0.05096083,0.008235804,0.01624074,0.07550317,0.061634153,-0.08275645,-0.05048232,-0.08586794,-0.086909585,0.0048045064,-0.0002700507,0.013899568,-0.00798102,-0.014724793,0.0139570255,-0.024547566,0.08163084,0.031211535,-0.019761868,0.056854624,-0.03535661,-0.048798542,0.014266604,-0.04755515,0.0662684,-0.01516307,-0.08140157,-0.04014492,-0.04070789,0.0016627143,0.022748644,-0.022950385,-0.037583742,-0.046024937,0.00807533,0.008211661,0.013754451,0.030478865,0.041269884,0.06305596,0.062248953,-0.00530758,0.024597796,-0.051289584,0.056395326,0.022045624,0.08030106,-0.02911158,-0.033599447,-0.015077845,-0.080707595,0.039400894,0.0068194014,0.012638685,0.059365902,-0.010209087,0.0039969566,0.02736703,0.004534108,-0.056718264,-0.027140189,0.0030603167,0.018834984,0.13406013,0.049989995,-0.038034502,-0.028588068,-0.029591147,0.018916195,-0.0043590437,-0.03475818,0.12184548,0.07007998,-0.043206178,-0.016062561,0.030200101,0.010829873,0.012354358,0.06556777,0.051177718,-0.014469824,0.032242592,-0.113674186,2.23456e-33,0.06991401,0.061212085,0.049883366,-0.030860553,0.01920541,-0.065719455,-0.10282818,0.0061450694,-0.079841785,0.044238124,-0.035453334,-0.027179174,0.039426476,0.022080967,-0.005445443,-0.062328465,-0.054267343,0.0330703,0.05266823,0.027359793,-0.041822635,0.014890174,-0.0024432861,0.009994415,0.020240381,0.032190625,0.018967284,0.059148118,0.08705637,-0.0051430166,-0.026513463,-0.05107305,-0.12044105,-0.023688773,0.05337982,-0.012228545,-0.042561147,-0.0065485584,-0.005467177,0.093856245,0.069139525,-0.014250863,-0.0102576595,-0.043181207,0.050157227,-0.053734906,-0.060475618,0.104659125,0.024138814,0.075573675,0.054357857,-0.0054217423,0.114067376,-0.009394383,-0.107980974,-0.007893575,0.007630361,-0.019774383,0.0012981026,0.037419327,0.03177873,0.030680379,-0.034677222,0.018641027,0.0165655,-0.035984263,-0.056379855,0.047951683,-0.029674418,0.07071647,-0.10106933,0.0012683171,0.04843795,0.0165525,0.05582303,-0.015295218,-0.07544727,0.010516882,0.0764295,0.02415139,-0.027827468,-0.011270331,0.026248982,-0.053227913,-0.041628987,0.046305437,-0.037011925,-0.06400364,-0.034309432,0.091685496,-0.004418264,-0.06800604,-0.01976487,0.043168508,0.059152745,-4.023461e-33,0.11165396,-0.10259403,0.017069204,-0.07569817,-0.042327702,0.024432365,-0.04305687,-0.052329466,0.027214538,-0.026630595,0.12294403,-0.031941008,0.015259407,-0.027697079,0.009253847,-0.031907298,0.052391578,0.082098156,-0.06669801,0.044113353,0.023694001,0.030814977,0.023468154,-0.03347037,0.041429598,0.02791593,0.014469772,0.06049452,0.07142632,0.071018755,0.036258545,-0.05046655,-0.009536316,0.0014640233,-0.06979435,0.10732489,-0.11295351,-0.0075184107,0.08582709,0.006342483,0.013339588,-0.005577854,0.009882649,0.055308733,0.08317176,0.053242467,-0.097326644,0.018438976,0.0501167,-0.0590332,0.0044538327,0.032971635,-0.0293417,0.008595209,-0.0014055775,0.077370435,0.037967473,-0.022829453,-0.0076109604,-0.043111447,-0.05697376,-0.011160251,0.00679778,-0.06195916,0.061263718,0.02656817,-0.032383207,0.035787538,0.093418196,-0.0500353,0.06684293,0.03644771,-0.03508661,0.007408557,-0.04360338,-0.039502922,-0.04338666,-0.033467576,-0.031444926,-0.015456236,-0.006034738,-0.049978398,0.003649303,-0.111920066,-0.030549865,-0.12391403,0.02251522,0.031859126,0.016921071,0.06879004,-0.023115631,0.014091409,0.05529671,0.05152303,0.020386124,-4.7056268e-08,-0.003628864,-0.09128193,-0.032066282,-0.04111844,0.03868925,0.008238754,0.0018838648,-0.06688209,-0.010695915,-0.062460024,-0.0017345942,0.05086679,0.022964438,0.04062649,0.014416955,0.012764302,-0.0727092,-0.01734683,0.025964294,-0.05352857,-0.11231954,-0.053169273,-0.04355796,0.023550078,0.0062849713,-0.07128844,0.065750726,0.080231406,-0.010033777,-0.010547067,-0.016489537,0.047252618,-0.059627093,0.039069854,0.00020543823,-0.02304015,-0.06024346,-0.009302844,-0.037834376,0.059377246,0.06590156,0.016536236,-0.12135603,0.012464679,0.007199538,0.011721588,-0.011453775,0.039280657,-0.054210037,-0.0054336553,0.037488446,0.016403517,-0.02345468,0.043118145,-0.071179815,0.04024776,0.03171193,-0.10185296,-0.046875097,-0.035195872,-0.0061410945,-0.04004615,0.19739656,-0.071754135 +1.3.98.5,"The enzyme participates in a heme biosynthesis pathway found in Gram-positive bacteria. The initial decarboxylation step is fast and yields the three-propanoate harderoheme isomer III. The second decarboxylation is much slower. cf. EC 1.3.98.6, SAM-dependent heme synthase.",384,1.0,-0.074756004,-0.05309194,-0.06851881,-0.017305303,0.0033859967,0.020781947,-0.112508096,0.034918748,0.020175416,0.037389647,0.019730605,-0.05709571,-0.09648164,0.02453638,-0.013401683,0.008403937,-0.08079764,0.08457079,-0.04698452,-0.05930049,0.075911835,0.08079693,-0.066922136,0.03329661,0.08026181,-0.036145873,0.08728687,-0.012043342,0.042374533,-0.082689725,0.011897057,-0.103670634,0.16452773,-0.021776183,0.04488797,0.03712573,0.005496208,-0.09582631,0.099558,0.033098035,0.04062253,-0.0103108995,-0.023719348,-0.07428119,-0.07331825,-0.0026704695,0.058349106,0.0126282,0.014808778,-0.042752225,-0.02889086,0.0025139858,-0.06870195,0.0046689194,-0.030587934,-0.029607167,0.029555965,0.026038764,-0.014238785,-0.045915563,-0.025164552,-0.008077852,0.0051582707,-0.037145067,0.03264054,-0.072954625,0.032071482,-0.026811352,-0.018392434,-0.036866765,-0.024846751,-0.067404106,-0.057943765,0.034076013,-0.06301827,0.028924061,0.0117166415,0.010876953,0.027422752,-0.046992365,0.045461886,-0.031342816,0.029236948,0.09608872,-0.038596865,-0.010885789,-0.06138043,0.026641656,0.0011914179,0.041459575,0.048311047,-0.009248618,0.01909685,-0.06996549,0.045796968,0.048731655,-0.0009338667,0.0728684,0.021496324,-0.009251491,-0.008103487,0.056665085,-0.0076739127,-0.06546902,-0.0010792618,-0.016279915,0.006660067,0.054848004,0.06920061,0.03957689,0.030867446,0.008776363,0.09984226,0.02447121,-0.10324898,0.09365239,0.0017197937,-0.053369608,-0.016356587,-0.016951578,-0.0266257,-0.032054525,0.013299164,0.01184287,-0.019426687,0.03798878,-0.07603062,2.0345838e-33,0.06278812,0.04613953,0.013865262,-0.030048285,-0.031886917,-0.039761797,-0.1078627,-0.010145416,-0.057630967,-0.0152517725,-0.04724596,-0.07500951,0.032994684,-0.038013235,-0.019234601,-0.05159875,-0.044692744,0.012410093,-0.06434782,0.0084815845,-0.019264681,-0.007890633,-0.058395315,-0.027425194,0.032258313,0.024204396,0.038144156,-0.030962197,0.035336435,-0.014064347,-0.016865019,-0.081566736,-0.043868933,-0.01679705,0.10550372,-0.052543603,-0.013280851,-0.019205127,-0.050315667,0.05697724,0.028560905,0.06097318,-0.006652769,-0.031084679,0.08393008,-0.012361359,-0.0036090617,0.040260047,0.06226171,0.09813839,0.020149225,0.025850924,0.07721176,0.0003521328,0.017896343,-0.04176008,-0.020090185,0.031162001,0.13553144,0.028795162,0.004910653,0.026896106,-0.025667321,0.025870787,0.024254926,0.04892374,-0.08702501,-0.015272138,0.038114507,0.09502533,-0.042414654,-0.054650966,0.019115955,-0.035480313,0.048473816,-0.05165465,-0.037818518,0.016122798,0.08339387,-0.1190883,-0.03717167,0.032243583,-0.03775613,0.004025448,-0.0650178,-0.04245941,-0.044277016,-0.015536471,-0.07881109,0.03018245,0.09891447,-0.054674126,-0.067492075,0.08637612,0.0304253,-2.395037e-33,0.09240978,-0.10859045,-0.007771463,-0.08812429,-0.037723016,0.050557125,-0.023411449,0.008769743,0.019705798,-0.013251507,0.08552386,0.0093533285,-0.005179988,0.014527289,0.042521104,-0.019374179,0.08527671,0.056151208,-0.030898288,-0.010635858,0.094037384,0.07470671,0.017524594,0.015478755,0.0007796612,-0.024286529,-0.04675872,0.1574295,0.008143313,0.07323662,0.013853546,0.03685975,-0.07109269,-0.013046373,-0.09417474,0.049853288,0.0046774456,0.058138933,0.010124254,-0.011617127,-0.008407209,0.008621796,0.040984977,0.10925452,0.07035025,0.09218516,-0.04796318,0.023416016,0.0063723465,-0.024973584,-0.00052558986,-0.008535598,-0.026097918,0.030073693,-0.016530735,-0.027580157,-0.036350936,0.00035406993,-0.06460494,-0.02493726,-0.09497609,-0.032115407,0.09614662,-0.003332418,-0.010264437,0.019924806,-0.036575153,0.06491925,0.115186214,-0.050879158,0.039092638,0.03212712,0.024882728,0.03721659,0.029001039,-0.07392702,-0.021342987,-0.05110355,0.042111315,-0.06070806,-0.08891073,0.01899762,-0.026551053,-0.08057454,0.0009934981,-0.0111820055,0.007955111,0.083649576,-0.013162845,0.036572658,-0.05261351,-0.020154083,-0.0020234166,0.09471023,-0.014972165,-3.6257095e-08,-0.011670504,-0.09571901,0.011226686,0.0036402987,0.008406043,0.0857842,-0.029711232,0.10335858,0.027801191,-0.031765617,0.009242527,0.02607018,-0.030179566,-0.0066517564,0.09223981,0.07746798,-0.0761747,0.014487666,-0.022442976,-0.04343983,0.011743267,-0.0059408313,-0.00981178,0.07329175,0.008453093,-0.02081317,0.025787475,0.014415651,-0.04162496,-0.0010916172,0.033313673,0.09083314,-0.018610625,0.031749066,-0.03454113,-0.04887507,-0.014905648,0.038846124,0.026951939,0.018101921,0.03896578,-0.006471703,-0.15161254,-0.018491022,0.012431506,0.06849061,0.042937063,0.040227685,-0.035460565,-0.08452363,0.061580602,-0.05490802,-0.0005633446,0.0010973158,-0.067100324,-0.039280277,-0.03127461,-0.052655164,0.0031244569,0.018570028,0.05440027,0.000475889,0.1573653,-0.027080135 +1.3.98.6,"This radical AdoMet enzyme participates in a heme biosynthesis pathway found in archaea and sulfur-reducing bacteria. cf. EC 1.3.98.5, hydrogen peroxide-dependent heme synthase.",384,1.0,-0.06601511,0.0077671,-0.11250794,0.0124945855,0.099878214,0.01885571,-0.09051284,0.0658296,0.054314703,0.0029349665,0.0015682994,-0.011952232,-0.06100389,0.018550439,-0.029551499,0.11210288,-0.11329441,0.030123588,-0.032180086,-0.07175748,0.029048273,0.09989819,-0.035935555,0.011859446,0.0126324985,-0.0014946744,0.10632904,-0.06379876,-0.07070641,-0.029127125,0.06966205,-0.070533335,0.10439733,-0.025755215,0.038083006,0.071347155,-0.007352386,-0.1073651,0.015326411,-0.03667026,0.050313387,-0.0026485894,-0.04963199,-0.017866887,-0.051024526,0.03008793,0.11187198,-0.0106402645,-0.019046502,-0.044854663,-0.032162286,-0.008089371,-0.09216511,0.0069685318,0.020649347,0.039269984,0.013599992,-0.022628509,0.0440483,-0.0663195,0.034014508,-0.010804842,-0.010531253,-0.032854445,-0.07515517,-0.059602454,0.1011406,-0.032290168,-0.04755359,-0.09513382,-0.04478616,-0.032190397,-0.04667189,0.026591597,-0.04015646,0.072946735,0.0027053747,-0.062469877,0.044763543,-0.035670716,0.030091004,0.005145648,0.023639955,0.10657201,0.033668295,-0.01937465,0.024830421,-0.018242113,0.013998015,0.0144228935,-0.03740877,-0.045473073,0.0028275799,-0.068997905,-0.05211143,0.028082121,0.06421173,0.073189944,0.015378658,-0.033047196,-0.053831935,0.053702455,-0.046889797,-0.051620666,-0.034456674,-0.026206262,0.02463726,0.14107743,0.07677453,0.0403019,0.038892966,-0.018929016,0.040289525,-0.008368918,-0.015495981,0.08392999,0.022794265,-0.07082996,-0.094888404,0.033582903,-0.017177178,0.025173845,0.01491732,0.033408068,-0.013360581,-0.010996396,-0.13060014,1.2991188e-33,0.08271221,0.08465649,0.0142728975,-0.049285557,-0.0037516516,-0.029169567,-0.15598978,-0.014305298,0.061676174,-0.007266463,-0.05823196,-0.09688391,0.052081767,-0.039749015,-0.056266602,-0.0437815,-0.025423935,0.005184936,-0.038029343,0.03292347,-0.06675734,-0.011789737,-0.08994039,-0.020001667,0.011784868,0.017749002,0.07287543,-0.04087265,0.06310169,-0.005092887,-0.04033705,-0.08135872,-0.0680764,-0.059831392,0.08897561,-0.007815033,-0.029890636,-0.014994858,-0.05297017,0.019319052,-0.012098687,0.061868638,-0.0021833458,-0.062902644,0.093671,-0.065107815,-0.01862438,0.07598103,0.0636543,0.10912323,-0.043795545,-0.029087724,0.13851374,0.021914676,-0.021171695,-0.04893994,-0.018833505,0.010018333,0.0892229,0.028266702,0.017729174,0.039802082,-0.045542676,0.04537426,0.018052278,0.025623417,-0.009625389,-0.018001422,0.026363093,0.06503328,-0.027547507,-0.008709935,0.04751767,0.0029691164,-0.05565031,-0.05030152,-0.017728493,0.04904242,0.09287572,-0.04120229,-0.045189273,-0.057285525,0.04666429,-0.015239544,0.01127705,0.0045212507,-0.056877337,0.014457064,-0.059066147,0.015495491,0.081018515,-0.0912574,-0.05552023,0.019395292,-0.012701418,-1.1816003e-33,0.02946431,-0.032687385,-0.025795322,-0.11602901,-0.0077029853,0.079550765,-0.057069905,0.028537117,-0.030889839,-0.043201122,0.08166229,0.018985985,0.029116226,-0.035989206,0.0567,-0.0074099978,0.055586632,0.01990875,-0.033667803,0.04180239,0.059252948,0.020184422,-0.0037009811,0.0040047206,0.026552321,-0.014141211,-0.002371097,0.06813753,0.054526195,0.050303563,0.0027380353,0.049888104,-0.045198105,-0.049148276,0.013294683,0.02079021,0.00079862314,0.079824194,-0.00035927934,-0.040227123,0.03322476,-0.022545572,0.045386497,0.12743385,0.039246473,0.08270909,-0.0818154,0.07077897,0.024163898,-0.039050166,-0.010551547,0.0011334629,0.030344946,-0.03082699,0.0038815127,-0.021121366,0.02497136,0.023603562,-0.046706133,-0.05536998,-0.08045784,-0.022282427,0.10164939,0.02045253,-0.022781024,0.029187398,-0.061772514,0.051210072,-0.007303945,-0.013783012,0.0057227258,-0.011574283,0.0011754546,-0.008444814,-0.007181715,-0.07703652,-0.032134257,-0.0023069656,0.0662749,0.058770977,-0.023906104,0.033703513,-0.009840267,-0.11623089,0.0051021264,-0.048734244,-0.010540055,0.08243263,-0.035172146,0.0030851364,-0.067502715,0.008773536,-0.06008558,0.021536501,-0.0025508278,-2.7962049e-08,-0.034953162,-0.047737632,0.07271757,0.025365382,0.024217075,0.043146063,0.037194222,0.08809915,0.024876261,0.03095457,0.01303227,0.083697066,0.0062571103,-0.02739363,0.042061314,0.07311451,-0.004372453,-0.0070217545,-0.015110732,-0.008910759,0.0015789586,-0.010948268,-0.032830633,0.07204112,0.037919417,-0.07246853,0.03362627,-0.03383098,-0.008505396,-0.051235028,0.05918906,0.071130805,-0.004973424,-0.0018554045,-0.061671585,-0.013844536,0.04248274,0.014064515,0.01277688,0.010356986,-0.03163994,0.0028193602,-0.094899155,0.0107764555,0.041745108,0.0732395,0.025356743,0.039655056,-0.063034944,-0.067746356,0.026865391,-0.013130911,0.038129833,-0.065334044,-0.10433564,0.01963348,0.069172926,-0.04018001,0.023507122,0.014394441,0.052141488,-0.019476019,0.1420405,0.026940746 +1.8.1.21,"The enzyme's activity has been demonstrated in the bacterium Thiobacillus thioparus E6. The methanethiol formed is eventually oxidized to sulfate and carbon dioxide, and the latter assimilated for autotrophic growth.",384,1.0,-0.041796442,-0.03451402,-0.066781424,0.006701732,0.03588101,0.038782004,-0.09851153,0.05919489,0.02831971,0.035659827,-0.023919253,-0.05336243,-0.020341938,0.0060178996,-0.003165895,0.025680816,-0.08337539,-0.047892187,-0.020338574,-0.06790195,0.07092408,0.047985412,-0.04765676,-0.023327088,0.07236092,-1.004626e-05,0.05966496,-0.029721612,-0.024147732,-0.052607413,-0.058064852,-0.040584654,0.037303004,-0.025765961,0.061052915,0.09634693,-0.013723398,-0.027631165,0.0872476,-0.079587266,-0.0044541126,-0.056726366,-0.010394744,-0.065801464,-0.05272931,0.039322417,0.07562666,0.07873687,0.014813856,-0.0748381,-0.034932543,-0.050081003,-0.031261392,0.022552988,-0.028076887,0.038494714,0.0010845672,-0.018564846,0.009128149,-0.051776063,0.071145594,-0.01697477,0.08680719,0.035942793,0.0214304,-0.03753701,0.081549235,-0.049912773,0.0004628664,0.0014209824,-0.106757484,0.038494144,0.012689216,0.059737477,0.014768651,-0.052592747,-0.008970736,-0.009047137,0.11269097,-0.022127584,0.004813302,-0.010743675,0.033862162,0.089037925,-0.023699015,-0.021466615,0.03870935,-0.011592016,0.052619006,0.014133508,0.010605563,-0.004006325,-0.029410077,-0.05583492,-0.047027618,-0.043097697,0.006582317,0.023558393,0.07617486,-0.07161381,0.03710241,0.036599714,-0.07722524,-0.10825511,-0.0062772757,0.030656813,-0.001261341,0.1004299,0.07473132,0.02124621,-0.013826829,0.040619124,0.025175922,0.021976536,-0.03058018,0.092440434,0.055438012,-0.0705839,-0.13722974,0.038050096,0.012499929,-0.0025117141,0.043880153,0.05214654,-0.060955737,-0.021345403,-0.068025045,2.484056e-33,0.06282907,0.0032400012,0.004468953,-0.06366046,0.05219572,-0.01989675,-0.06801943,0.020282777,-0.04202993,-0.0062735635,-0.075548664,-0.07072432,0.0074962736,0.043135837,0.0071364315,-0.0012938763,-0.021309886,0.03794251,-0.003206254,-0.010580903,-0.0058316607,0.024473071,0.00056439254,0.02928517,-0.00046559292,0.097456455,0.08298448,0.065909624,0.007277496,-0.008416109,0.0649379,-0.15339673,-0.09736628,-0.004416106,0.10006271,-0.023585314,-0.07559655,0.09727466,-0.04804026,0.009515183,0.09132457,0.11049848,-0.022299131,-0.10064733,-0.02093539,-0.075022765,0.021374479,0.11716813,0.05802532,-0.016320141,0.00034680398,-0.054940056,0.05972091,-0.088554844,0.011273798,0.023960657,0.026810529,0.003734085,0.013671491,-0.014977719,0.029692488,0.034359295,0.0013051354,0.089971036,-0.057175934,0.052429717,0.0032590167,-0.010693216,0.03681348,0.08762759,-0.049716443,0.016054144,0.025435675,0.022995453,-0.028144896,-0.043116827,-0.04588559,-0.051097337,-6.81593e-05,0.029147075,0.048626576,-0.103205316,0.038036797,-0.07286486,-0.03547152,-0.054697,-0.057524815,-0.044089057,0.011267595,0.09820426,0.028151274,-0.095489144,-0.05797021,0.029953873,-0.021551087,-3.40786e-33,0.06375285,0.017244985,0.022193532,-0.07462075,-0.026739249,0.027299408,-0.05666712,0.029550359,-0.018370973,-0.020153701,0.0913491,0.050910737,0.032092806,0.0027284585,0.04409976,0.007076719,0.060847756,0.0361914,-0.0014804883,-0.019623995,-0.03449649,-0.015361471,-0.011131499,-0.03566675,0.038431507,0.030507982,0.008924822,0.08577736,0.020723002,0.065375924,0.030301787,-0.0013445144,-0.049926132,-0.021840427,-0.04664985,0.0021464862,-0.044566978,-0.03668932,0.08947965,0.034521263,0.044466708,-0.017573744,0.012995997,0.058583304,-0.058230165,0.0014698388,-0.040570196,-0.057122275,-0.026099063,-0.025498154,0.06349306,-0.026842462,0.034223296,-0.00082969386,0.013546442,0.07586886,-0.012725819,0.04861761,-0.054668114,-0.054903757,-0.066054255,-0.074088395,0.0134907095,-0.038605962,-0.032348167,0.018932747,-0.12844247,0.061941966,0.030959643,0.05131211,0.049927723,0.037655037,-0.026793897,-0.018154515,-0.04442535,-0.005564666,-0.04768887,-0.020420529,-0.0005258049,-0.02412359,-0.035243027,0.034377996,-0.01097004,-0.0931266,-0.026583584,-0.065170266,0.004091417,0.067276195,-0.045718305,0.09758653,-0.059767198,-0.015495972,-0.04048907,0.053351693,0.06032818,-3.2908755e-08,-0.04488793,-0.06868506,0.07278224,0.06290254,9.928507e-05,0.0561935,0.034742035,0.042657796,-0.007908287,-0.0014474065,-0.05625669,0.09301907,0.06102144,-0.05844592,-0.0011956703,-0.03759686,-0.03329113,-0.013033704,-0.03003989,-0.055305317,-0.0036087553,-0.03210652,-0.02405018,0.037682224,0.073841624,-0.026139928,0.01085419,-0.077936575,-0.05314334,0.008036584,-0.028900778,0.07509239,-0.040686343,-0.058812696,-0.043017652,-0.013125189,-0.080739364,-0.052059233,-0.067146055,0.012477078,0.0820767,0.11257811,-0.117895186,0.028500192,0.008231617,0.03433124,-0.00867987,0.038285855,-0.04832829,-0.041740667,0.046711423,-0.03464336,-0.04887452,-0.0020446652,-0.03391629,0.08646909,0.0301289,-0.024229182,-0.058087707,0.037022725,0.015659876,0.0418799,0.16056375,-0.0859275 +1.13.11.89,"Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway. It also has the activity of EC 1.13.11.78, (2-amino-1-hydroxyethyl)phosphonate dioxygenase (glycine-forming).",384,0.99999994,-0.045894247,-0.004845165,-0.03305451,0.034482192,0.047256608,0.018201515,-0.017402725,-0.017662128,0.008543542,-0.024107853,-0.02551498,-0.046734326,-0.007043765,0.025530528,-0.02696502,0.00810034,-0.042917777,-0.02928066,-0.044924375,0.047941014,0.043635912,0.0792905,-0.059438262,-0.04511637,-0.029979883,0.024959574,0.053264834,-0.008398439,-0.048396442,0.01739637,-0.0034719715,-0.024748307,0.11821013,-0.06721543,0.025888948,0.13043186,-0.00022425165,-0.13116215,0.016121982,0.04531416,-0.054136045,0.012486825,0.010254224,-0.040498402,-0.024715103,-0.06627587,0.059946265,-0.006135082,0.021721154,0.051989283,-0.067858085,-0.05878232,-0.017519318,0.032793287,0.029437682,0.008173295,-0.017031867,-0.012874896,-0.066667356,-0.021226995,0.022993205,-0.019125635,-0.031744413,0.010694459,0.00019639816,-0.025453601,0.10028094,-0.06468386,-0.021794805,-0.044598073,-0.030788546,-0.043493003,-0.09095202,0.01195061,-0.054728683,0.09541106,0.04992398,-0.06809297,0.09094173,-0.030027546,-0.046231166,-0.020582188,0.015046305,0.029886845,0.036807124,0.051347993,0.022898234,-0.032152716,-0.028982706,0.07665532,0.0024732677,-0.026970563,0.04816534,-0.07694726,0.045246504,0.056011528,0.004734552,0.03790486,0.019242091,-0.008248461,-0.052939642,0.076414265,-0.03374152,-0.0817845,-0.022355186,-0.0070200963,-0.02254461,0.11117976,-0.020416569,0.019517194,0.012438796,-0.014623068,0.028318396,0.014268663,0.04403189,0.12531003,0.085342206,-0.05899089,-0.09952846,0.048809163,0.04348483,-0.026692461,0.0076189428,0.035570398,-0.06242945,0.0116834855,-0.08757814,-1.1260566e-33,0.08641642,-0.0017482204,0.028116189,-0.048486568,0.033877023,0.031721827,-0.14643227,-0.03148577,-0.009327463,-0.07088833,-0.095480494,0.005516081,0.04845102,-0.00654398,0.005603435,0.011946398,0.019969547,-0.00709359,0.08772067,0.008580916,0.049756866,0.021636827,0.05845138,-0.043441862,0.028822247,0.08621051,0.019193243,-0.046502654,-0.021028025,-0.00810709,0.032373253,-0.18715033,-0.12139272,-0.039132185,0.06962682,-0.019878717,-0.02334517,-0.013202007,-0.061377946,0.018310409,0.035901528,0.030489743,-0.03234999,0.0004664002,0.078937694,-0.07441324,-0.032681797,0.11673347,0.016449206,0.09214142,0.035064068,0.008607771,0.052766617,-0.019903457,-0.05348827,0.014738169,0.040488034,-0.034400344,0.02298184,0.07007798,0.005572087,0.03597848,0.045732994,0.088262714,0.10516155,0.016307775,-0.07778877,0.017654374,-0.018856518,0.049583223,-0.040448837,-0.058933042,0.068897106,0.028674196,-0.041829094,-0.08186071,-0.0333429,-0.04565678,0.047841854,0.03287888,-0.02484842,-0.019812932,-0.01235761,-0.048590023,-0.08274151,0.014365322,0.00061248534,-0.043224122,0.03966706,-0.0054102177,0.042075716,-0.037715945,-0.08954994,-0.039010145,-0.009699084,-1.6798038e-33,0.040843025,-0.063396834,0.02471351,-0.06403539,-0.020952433,0.04398858,0.01985552,-0.03207248,0.021557339,-0.014204566,0.064311564,-0.0056414786,0.025984585,-0.064551175,0.019690176,0.036583748,-0.02174359,0.080098405,0.014194576,-0.013800232,0.029469246,0.06642665,0.034677558,0.039212793,0.03271339,-0.020784965,-0.08625602,0.020180652,0.021783486,0.077631205,-0.0067904256,0.05830159,-0.02699524,-0.103669114,-0.01972474,0.057987154,-0.051644947,0.031847704,0.058012232,0.017094228,0.032259904,0.011468372,0.069112346,0.11824775,-0.0033373109,0.07930883,-0.05952216,0.031073162,-0.03443082,-0.010498555,0.017129151,-0.044374056,-0.012114264,0.061190408,0.06843178,0.01803633,-0.016405746,0.09173141,-0.051137596,0.039226934,-0.008442032,-0.048453845,0.043668967,0.0019536861,0.03030428,0.019843718,-0.0050542876,0.057719402,-0.02275155,0.021086797,0.06890698,0.005704298,0.04215679,0.0024701557,-0.030404687,0.0022828043,-0.11975343,0.034381736,-0.038641483,0.011664936,0.042633235,0.045046777,-0.057780977,-0.043638214,0.005749458,-0.107687205,0.027238695,0.045550182,-0.020902138,-0.0010101213,-0.07451594,-0.05253525,-0.08091928,0.02507013,0.024275476,-3.801599e-08,-0.034200866,-0.029417112,0.06796053,-0.082599536,-0.0057984726,0.0006172741,0.04436396,-0.0012243944,0.018750934,-0.046231482,0.024636732,0.0808467,0.02442623,-0.04265071,0.017479323,0.034642648,-0.011309059,0.039508272,-0.021174312,-0.027643267,-0.04949547,-0.029526243,-0.05013324,0.04415125,-0.020383863,-0.03695912,0.039985914,0.016720373,-0.0070466124,-0.022012183,0.016574308,0.04772942,-0.041573454,-0.061042972,-0.18355495,-0.026216868,-0.021207117,-0.00665559,-0.071106136,0.03538427,-0.09544943,0.04412502,-0.11981018,-0.011820127,0.0022685688,0.03390973,0.0050884327,0.06974485,-0.04391131,-0.019050473,0.035726957,-0.016277973,0.030115876,-0.038577035,-0.10957836,0.10356501,0.020142611,-0.036447752,-0.008102295,-0.00035618574,0.0044170995,-0.017103799,0.188491,-0.0770513 +1.14.11.64,"Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.",384,0.99999994,-0.04472873,-0.07535943,-0.033641,0.06119739,0.14507894,0.015674556,-0.047512017,0.04885037,-0.017037299,-0.048575174,-0.023348723,0.013182176,-0.015021285,0.081409805,-0.01870211,-0.008421204,-0.043881286,-0.030156681,-0.056629468,0.024193764,0.100650586,0.08240098,-0.085430235,-0.029358923,-0.015671976,-0.053318348,0.03843145,-0.06001053,-0.013797209,0.014076404,-0.06897058,-0.071028925,0.05008608,-0.08568814,0.030970892,0.037905253,-0.033345826,-0.0840473,0.020989057,-0.0045496114,-0.05788096,-0.050655823,-0.026675694,-0.06277718,-0.0196322,-0.038523696,0.087704785,-0.033806615,-0.028948154,0.042879492,-0.02873634,0.016433546,-0.029203547,0.03537459,-0.049163617,-0.019622186,-0.027642842,-0.004882107,-0.060131174,0.013793529,0.020591926,-0.012353799,-0.001995862,0.023897089,0.052816037,-0.061400145,0.09127817,-0.037238047,-0.0016664116,-0.012646893,-0.045232214,-0.042428907,-0.050942216,0.042392183,0.03910854,0.04079865,0.04946748,-0.047216665,0.07759305,0.010830503,-0.0017896944,-0.027455566,0.0056659346,0.13038075,-0.0009567863,0.018152026,-0.007189323,0.009168275,-0.034936417,-0.014499404,0.04113403,-0.014671834,-0.01068321,-0.022033833,0.03346473,0.052921295,0.014845815,-0.0013964262,0.004186309,-0.021467585,-0.114837915,0.046222575,-0.004482003,-0.01340694,-0.03704207,-0.036913037,0.0040346766,0.11383288,0.030910185,-0.0018727712,0.09771953,0.015808167,0.050333984,-0.006686802,0.037829705,0.051479314,0.13290855,-0.052262936,-0.059051666,-0.0009285055,0.048025012,0.0015045842,0.036903802,0.085581295,-0.02128507,0.013528122,-0.031084523,2.1364892e-34,0.044765968,0.0022207662,0.016766539,-0.041403282,-0.03152373,-0.004575496,-0.11537622,-0.05290884,0.0067695444,0.005464606,-0.03102209,-0.052814793,0.043596417,0.02427994,-0.018464863,0.005876782,0.009744023,-0.045444053,0.09451092,0.040937684,0.064334214,0.06964002,0.06438518,0.0016415546,0.037847564,0.093871504,0.063576154,0.002548084,-0.072875924,0.0016152108,0.020495351,-0.11993109,-0.09246809,-0.028411381,0.07444284,-0.035778396,-0.05911552,-0.01964281,-0.0012766677,-0.004931149,0.092041075,0.11193179,-0.04566409,0.012867442,0.11865221,-0.071741916,-0.032170877,0.17138886,-0.103525564,0.085664965,0.044734217,-0.014687759,0.01829117,-0.0025167677,-0.05679065,-0.0052632107,-0.003799644,-0.033796646,0.036548056,0.07445984,0.073766574,0.04691412,0.015557775,0.12431281,0.07666246,0.0070305313,-0.06248814,0.03360378,0.012861282,0.027925998,-0.0924591,-0.018033378,0.045665286,0.027715987,-0.020725155,-0.119592786,-0.08465822,0.029614812,0.07645937,-0.03234411,0.02529652,-0.05886663,-0.009693791,-0.0043088547,-0.07185878,-0.01651578,-0.0019452287,-0.042581785,-0.005226799,-0.04602449,0.045266736,-0.066547915,0.003673096,0.027679767,-0.029105062,-2.0437914e-33,0.04808138,-0.083461024,0.05779347,-0.0474467,-0.022427674,-0.024146596,0.005219803,-0.081653275,0.026555078,0.014805051,0.07277549,-0.0031419569,-0.0307418,-0.04996183,0.041767117,0.055624906,-0.050194573,-0.017493542,-0.006911383,-0.029492833,0.008681485,0.0667143,0.05360654,-0.022997428,0.08402677,-0.0038466055,-0.104856536,0.059864298,0.019120902,0.046450775,0.023022564,0.010187532,0.0017997206,-0.12804629,-0.013382108,-0.0067599276,0.014600237,0.05467728,0.0776453,-0.04012971,0.054181237,-0.0076157786,0.014717005,0.080253005,-0.03810649,0.06964443,-0.09611229,-0.04561435,0.016841292,-0.043122724,0.00018382959,-0.091161124,-0.06117793,0.009517335,0.016389403,0.03870677,0.019556222,0.09281954,-0.086717345,0.047468755,-0.03364694,-0.04261498,0.014068712,0.044120368,0.06349699,-0.010838812,-0.011014909,0.08091095,0.001875859,-0.0052236626,0.074139416,0.0022224577,0.09622959,-0.043379083,-0.044442542,-0.004780837,-0.06383486,-0.01578076,-0.01346996,0.020615067,-0.039896913,-0.042386767,-0.05387766,-0.017071705,0.042003624,-0.12438726,-0.021630438,0.060615487,-0.018086005,-0.027585559,-0.056994595,-0.07493839,0.011907225,-0.01006574,0.033683144,-3.575496e-08,-0.004473563,-0.047824953,-0.008583917,-0.042132862,-0.014767156,-0.0016580822,-0.037456844,0.006472581,0.023126066,0.0024057513,-0.0082682315,0.10459949,-0.0038059577,-0.070596546,0.04403301,0.018799573,-0.04177684,0.02822947,-0.038997505,-0.032538127,-0.077880405,-0.06327422,-0.06556533,0.025113134,0.005575137,-0.061219938,0.029754357,-0.0013416533,0.018099837,-0.03247811,-0.00067310623,0.029114597,0.031040018,0.011038797,-0.11691825,-0.008743258,-0.003010268,-0.010757863,-0.010804693,0.036866546,-0.025914168,0.058657568,-0.094494864,-0.0061046807,0.04993583,0.005367609,-0.02818452,0.050203796,-0.027858192,-0.015200234,0.04465438,-0.039855357,-0.013659875,0.028314708,-0.052386235,0.061805997,0.014598419,0.0069649895,0.05086064,0.003354703,0.0018309784,0.030140944,0.17028789,-0.0909007 +1.14.11.65,"Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the di- and mono-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.66, [histone H3]-trimethyl-L-lysine9 demethylase.",384,1.0,-0.03588504,-0.03378151,-0.071959324,-0.022447702,0.12857354,0.0357966,-0.005991508,0.013120469,-0.09435272,-0.07097189,-0.011747776,-0.027464733,-0.025935037,0.024198528,0.042311706,0.06046422,-0.0833553,-0.020019004,-0.08341825,-0.0368046,0.044032373,0.10558627,-0.017193843,-0.03340598,0.029764565,-0.045947243,0.11230039,0.023578407,0.019255152,-0.02393919,0.0037467289,-0.049980983,0.017083481,-0.04275662,0.08671978,0.051404063,-0.036224596,-0.04078276,0.029152118,0.022664528,0.021844346,0.005376652,-0.060562886,-0.02319334,-0.061458465,-0.0016878902,0.02705654,-0.029653927,-0.047488734,0.06327081,-0.013710699,-0.0059336564,0.017686203,0.02961775,-0.05043074,-0.08400619,0.004018513,-0.009350582,-0.03456574,-0.027396495,-0.009928228,-0.022893613,-0.016603226,-0.048247058,0.06514454,-0.024386674,0.08641016,-0.065053426,0.03236815,-0.04984456,-0.010288779,-0.042210232,-0.06434293,0.011876067,-0.0033110988,0.0046649496,0.03300897,-0.015834562,0.04126723,-0.043471497,-0.041811395,-0.0012051184,0.09993316,0.104853414,0.01191425,-0.0128959855,-0.09661626,0.04168222,-0.018794218,0.054922868,-0.030397976,-0.006616478,-0.0535521,-0.02822914,-0.008720638,0.06892011,0.09242195,0.0351745,0.017754955,0.027692508,-0.022887621,0.019202052,-0.07716618,0.046052113,0.016585425,0.055397484,0.009698932,0.06058607,-0.008769501,-0.019598067,0.04367579,0.0058295024,0.08249624,-0.0103478,0.01284833,0.07288439,0.047845323,-0.0049784854,0.014872389,-0.01738095,0.05871853,0.0690423,0.10534483,-0.004399721,-0.031055508,0.0070995186,-0.13387732,9.076699e-34,0.020890398,0.07773767,-0.027509442,-0.0061506755,-0.046730205,-0.048182797,-0.15846054,0.038924836,0.0062017115,-0.011058636,-0.0028212082,-0.033798218,0.050809328,0.009338608,-0.08946737,-0.04908028,0.009099144,-0.0070921914,0.02498287,-0.02839293,-0.03865989,0.023999188,-0.0063395253,0.023032451,-0.022309432,0.032379474,0.042942237,0.07533091,0.031969137,0.008611693,0.0059596454,-0.0800848,0.017526839,-0.008391579,0.063439295,0.073639594,-0.022470098,0.008163416,-0.024502734,0.027743854,0.08525213,0.021830933,-0.02842047,-0.08566037,0.008380132,-0.05581287,-0.039384857,0.060162213,-0.07158344,0.022177622,0.030254759,-0.003623582,0.08409434,-0.062223833,-0.057625413,-0.052123778,0.00907488,-0.01588787,0.09039104,0.07044752,0.03210013,-0.0028735353,0.017466731,0.08246679,0.06378752,-0.058412544,-0.07690333,0.046661515,0.022709215,-0.03501741,-0.013142022,0.011618117,0.11406433,-0.008491128,0.017418787,-0.08115844,-0.0849662,0.03478826,0.040039547,0.010438809,0.06506343,-0.0199197,-0.054149058,-0.056757454,-0.05626479,-0.0034411575,0.010667944,-0.080590844,-0.04169538,-0.045198955,-0.04576672,-0.052258883,0.026201215,-0.012344864,0.0020187842,-3.062866e-33,0.03734276,-0.014359632,0.012232915,-0.05657376,0.00046685536,0.009774363,0.08672354,0.012777022,-0.015139302,-0.032404065,0.105849415,-0.020178305,0.009323263,-0.11508539,0.03545874,0.09280225,0.013763039,0.056788724,0.026209513,0.005729748,0.003066067,0.03528568,-0.055949435,0.077871636,-0.011800365,0.02513932,-0.099706516,0.020448303,0.103862435,0.090483025,-0.050640948,-0.018036513,0.005548201,-0.08129264,0.036258128,-0.028134204,-0.03808537,-0.0046249456,-0.005998162,-0.026312403,0.029403577,-0.04417932,0.017884132,0.10460709,0.03308638,0.116732284,-0.112546146,0.03852917,-0.016802747,-0.024035,0.01040838,-0.037269484,-0.04770037,0.06501259,0.020376375,0.059395097,0.07547829,0.06564044,-0.036133286,0.067123085,-0.06926467,0.008869868,0.0017153955,0.059966043,-0.016462496,0.024936581,-0.07778376,0.0067581865,0.056024585,-0.012545934,0.026316263,0.008195737,0.039120983,-0.03615385,-0.036140013,-0.03752517,-0.014071983,0.021459194,-0.05885662,0.0024717336,0.051111653,-0.059248857,0.021873863,-0.003606523,-0.00640653,-0.13175201,-0.027830426,0.073317975,-0.011126788,-0.06802371,-0.008492716,-0.014524906,-0.06851721,0.05699223,0.04763887,-4.5313577e-08,-0.019687643,-0.13784164,0.06362371,-0.047659304,-0.04287227,0.043862965,0.065334104,-0.02056483,0.042791564,0.027107509,0.025174698,0.039229512,-0.066255786,-0.07020391,-0.024874602,-0.051185496,-0.03071933,0.096463375,-0.031645425,-0.058557067,-0.086212374,0.008000019,0.04618102,-0.028809844,0.0052736234,-0.0011757493,-0.08071806,-0.023807202,0.055040862,-0.052107804,0.030420886,0.09807152,-0.0058322353,-0.08476668,-0.11788741,-0.026314145,0.056677923,-0.038629837,0.04184159,-0.00041134286,0.0017015783,0.01230359,-0.14270657,-0.01292564,0.051464703,-0.029970799,-0.025571458,0.04412861,-0.041873105,-0.006292076,0.033776734,0.033380073,0.01490768,-0.016494619,-0.051147707,0.05027609,-0.0365944,-0.0008080886,-0.0136918835,-0.05807221,0.067857906,0.02548354,0.146632,-0.09908276 +1.14.11.66,"Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.65, [histone H3]-dimethyl-L-lysine9 demethylase.",384,1.0,-0.04199599,-0.029121025,-0.079655364,-0.021688955,0.12783583,0.03655672,-0.009156158,0.013264993,-0.092072636,-0.06968319,-0.013332431,-0.032541886,-0.024658691,0.02569515,0.0431539,0.056077007,-0.08163876,-0.020423489,-0.09098013,-0.039557565,0.04049594,0.10587534,-0.007745318,-0.03537809,0.019573314,-0.04279646,0.10914895,0.028888656,0.019829273,-0.02520418,-0.0034942913,-0.04335052,0.007431036,-0.044034686,0.089214556,0.04797181,-0.03383996,-0.034230784,0.025872592,0.02452078,0.024239315,0.0010429323,-0.05854331,-0.017519366,-0.06543726,-0.0009788539,0.021327937,-0.028510448,-0.041821774,0.063285924,-0.015125735,-0.005606466,0.019032862,0.027631246,-0.047000226,-0.07820902,0.0072273705,-0.007454295,-0.035935678,-0.029690336,-0.0028117744,-0.027726393,-0.01362842,-0.050240934,0.057486977,-0.023312734,0.08925628,-0.0695139,0.030354192,-0.05281904,-0.01637329,-0.043127034,-0.059303336,0.009577363,-0.0011813826,-0.0036320211,0.032666255,-0.017828837,0.042324934,-0.047670145,-0.039180838,0.006589879,0.104229406,0.102431245,0.0127835795,-0.0116592795,-0.09003983,0.040840354,-0.014446466,0.051489394,-0.03296703,-0.007275294,-0.05700163,-0.029819831,-0.0058183926,0.071571305,0.09307254,0.036663525,0.010798967,0.022393102,-0.013830679,0.02481313,-0.08404486,0.039632395,0.027887844,0.05427828,0.012406345,0.06506063,5.5071225e-05,-0.015423367,0.047220077,0.010383278,0.089392364,-0.0050195004,0.012848651,0.07550799,0.04280449,0.0029240465,0.018621096,-0.025609938,0.063804656,0.06788669,0.10971079,-0.0054978626,-0.034637254,-0.0013484269,-0.13317068,8.844438e-34,0.019249814,0.08724384,-0.029056337,0.0013662612,-0.05116659,-0.052663505,-0.15536295,0.04039902,0.00791964,0.0024023447,-0.0070766187,-0.030069986,0.048374165,0.01156327,-0.09300748,-0.04052945,0.00302523,-0.010064785,0.017644336,-0.033163738,-0.03246394,0.023442037,-0.0058098384,0.024511449,-0.017030437,0.03674129,0.046727482,0.08267786,0.034305856,0.005056189,0.011474227,-0.0841882,0.02286523,-0.00697564,0.06400516,0.069244616,-0.028542334,0.011779753,-0.0172575,0.031965066,0.08299376,0.016268684,-0.022457032,-0.08062082,0.0012842541,-0.04707215,-0.036921944,0.056521833,-0.06744111,0.008861363,0.031092143,-0.00160151,0.07689537,-0.060784727,-0.063247204,-0.04849968,0.0076245093,-0.014476274,0.08991907,0.0676435,0.02950818,-0.0066135125,0.02022514,0.08587322,0.061208453,-0.059944272,-0.083360344,0.039293926,0.02211651,-0.039754417,-0.0024959657,0.012519262,0.12379709,-0.012396671,0.020230344,-0.079022616,-0.0740978,0.02831709,0.03419131,0.016533729,0.06901113,-0.026035886,-0.056294374,-0.060669158,-0.058600888,-0.009362049,0.014034182,-0.08077472,-0.036860812,-0.04474998,-0.05156313,-0.048614237,0.031007964,-0.024872897,0.0003602149,-2.8534358e-33,0.038309395,-0.012716919,0.01332753,-0.060594905,0.0023806954,0.0069220606,0.0901194,0.012123791,-0.01038394,-0.033883236,0.10473486,-0.020431727,0.008799119,-0.116321556,0.03949183,0.1037062,0.0077669434,0.049416315,0.028880462,0.009521246,0.0019337727,0.032978628,-0.059670936,0.08387254,-0.004362437,0.029499795,-0.101996824,0.013046175,0.10080792,0.091697246,-0.051237278,-0.023763346,0.007527446,-0.072948016,0.035336632,-0.033156727,-0.03472241,-0.01905197,-0.013309282,-0.025388518,0.024473997,-0.04943343,0.012953877,0.100012854,0.036066297,0.118327715,-0.11025648,0.032246534,-0.017233696,-0.025364775,0.013518212,-0.039591737,-0.052145828,0.06133671,0.025174266,0.065695174,0.070685275,0.06450956,-0.027905555,0.0624963,-0.059855815,0.0033262176,0.005195389,0.0615564,-0.019091915,0.033340883,-0.081243,0.012702418,0.055255193,-0.00495173,0.02931407,0.011395128,0.036329206,-0.039712258,-0.04029886,-0.040245112,-0.012386298,0.02446063,-0.061298467,-0.00016100999,0.055726256,-0.056405373,0.017962864,-0.0005183396,-0.007370236,-0.12342695,-0.011835948,0.07997047,-0.013094111,-0.06628914,-0.013523328,-0.010336893,-0.069078326,0.058139894,0.056654185,-4.5089507e-08,-0.016957305,-0.13766918,0.061299037,-0.053917162,-0.04279461,0.0433837,0.06963953,-0.017417971,0.043643024,0.032500476,0.019242443,0.04017992,-0.06597458,-0.06881018,-0.029892309,-0.052095365,-0.035788443,0.10248906,-0.026878094,-0.06438464,-0.0783198,0.016438957,0.039710533,-0.031902473,0.0013964582,0.005487197,-0.070263304,-0.024274651,0.047086924,-0.05668616,0.028946375,0.08843236,-0.009822247,-0.08066384,-0.11839197,-0.024883196,0.055763043,-0.036898714,0.03976882,-0.0048009665,-0.0028827514,0.015020013,-0.1434513,-0.010863754,0.049596738,-0.033228282,-0.024503386,0.04401391,-0.040826768,-0.0051888647,0.030466441,0.0367326,0.017536024,-0.01932397,-0.049022514,0.050618086,-0.04361737,0.004681571,-0.018669823,-0.053790417,0.06034542,0.028585317,0.1392665,-0.10837234 +1.14.11.67,"Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 4 of histone H3 (H3K4). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri-, di-, and mono-methylated forms.",384,0.99999994,-0.043642517,-0.036478616,-0.069189005,0.03705518,0.10116901,0.0132351685,-0.013172311,-0.030238293,-0.06260741,-0.05335344,-0.010117447,-0.038068574,-0.020376196,0.013580224,0.020329498,0.067326784,-0.077516586,-0.03496368,-0.09027411,-0.014005484,0.044028275,0.07144315,-0.041861843,-0.036147673,-0.009313935,-0.044733852,0.10269429,0.008227376,0.030718066,-0.031802204,0.0047079297,-0.030113693,0.04035782,-0.04426168,0.064662114,0.07454007,-0.026875636,-0.051764026,0.0039846767,0.043338396,-0.02295866,-0.01570083,-0.062869295,-0.02775179,-0.060254492,-0.034861673,0.038001303,-0.037068933,-0.047336318,0.050124787,-0.035749987,0.008733804,-0.014727852,0.04999754,-0.055403437,-0.06603588,-0.018823624,-0.004602717,-0.030932127,0.017879497,0.02916879,-0.021229442,-0.041387938,-0.022680141,0.058237784,-0.016491124,0.0891866,-0.053947594,0.021563116,-0.07133125,-0.04615994,-0.055758987,-0.08277547,0.007948123,-0.008501529,-0.0072364816,0.034484267,-0.05019851,0.0782296,-0.05591108,-0.046333566,0.03760013,0.077194795,0.102728195,0.04440844,0.024618326,-0.07598267,0.015496785,-0.012134912,0.045076683,-0.01799177,-0.012976501,-0.039182566,-0.020531787,0.027117705,0.072384305,0.09632848,0.044963453,0.04244136,0.03082554,-0.035031896,0.04480523,-0.07912053,0.027379656,-0.019475238,0.0145383645,0.02035868,0.05642114,-0.00045615606,-0.0048337397,0.048211887,0.0006303596,0.085436314,-0.0070005953,-0.0004907789,0.08130947,0.083476424,-0.023558969,8.867986e-05,-0.02742845,0.067827895,0.058424104,0.093629256,-0.0018876959,-0.008682194,0.0050371285,-0.118087895,8.443732e-34,0.067815326,0.08524625,-0.014391876,0.011682605,-0.051816266,-0.026895987,-0.14810343,0.023112418,0.0007035107,0.022895891,-0.017713288,-0.030239671,0.05429341,0.01415256,-0.0739329,-0.04641947,0.008630452,-0.029194346,0.038227204,0.004822945,-0.02514074,0.054855917,-0.0047004437,0.01879333,-0.029972022,0.058818188,0.0497534,0.045569427,0.008292395,0.013100778,0.009768197,-0.12905204,-0.004442576,-0.015350991,0.046080973,0.059693754,-0.058212314,0.03055842,-0.015919229,0.024929257,0.06169599,0.048206147,-0.031476453,-0.055448767,0.020543715,-0.04715665,-0.04281164,0.0843873,-0.06871028,0.049692526,0.015701778,0.0065385224,0.074555255,-0.07788685,-0.065428846,-0.018054856,-0.020066224,-0.019906688,0.086719856,0.065027,0.043907184,0.010138283,-0.0025306155,0.11226746,0.07737632,-0.06840914,-0.07999884,0.03468535,0.019214323,-0.00018479623,-0.047128614,0.005221897,0.124978624,0.008521546,0.007187901,-0.08787659,-0.08699309,-0.00056097505,0.03680255,0.015736688,0.027229581,-0.03502324,-0.043942936,-0.08579033,-0.07818917,-0.020700717,-0.00068000786,-0.073876165,-0.012345968,-0.064595915,-0.046552554,-0.05174454,0.014850188,-0.042284645,0.028933479,-3.1299128e-33,0.056338195,-0.009984853,0.008078292,-0.06273582,0.009871955,0.017526694,0.060208175,-0.022511503,0.021292916,0.014334614,0.09576543,-0.0008073227,-0.0007659563,-0.08413754,0.044339854,0.08094177,-0.014207099,0.03994904,0.029706657,-0.0053499104,-0.007395219,0.067418344,-0.042296432,0.057449672,0.036560677,0.038528215,-0.1034389,0.014872798,0.10529366,0.09037168,-0.035751637,-0.0036392969,0.02646354,-0.09039752,0.026725382,-0.005557954,-0.044850495,0.013536868,-0.011399945,-0.023659743,0.0007474684,-0.04882981,0.050101455,0.15159859,0.02862705,0.079616144,-0.11429808,-0.022108296,-0.01050174,-0.017350685,0.0099688675,-0.03241787,-0.06749105,0.051683497,0.04115931,0.047548153,0.035757862,0.06480263,-0.049701404,0.062383547,-0.061138578,-0.020695066,0.027081877,0.04172754,-0.012502066,-0.007544312,-0.09445679,0.006892641,0.048398804,0.014424799,0.05018327,0.006934836,0.056264874,-0.049449485,-0.04327117,-0.056552894,-0.021794712,0.007185667,-0.06707727,0.0016190736,0.04536875,-0.03295555,0.0027171518,-0.0003468542,-0.040332444,-0.13526252,-0.015278434,0.06477587,-0.03102818,-0.067318015,-0.027360212,-0.04840264,-0.058954466,0.06036006,0.04321086,-4.2884988e-08,-0.04335125,-0.11943871,0.05755019,-0.04411473,-0.035893273,0.039580464,0.042745404,-0.008790897,0.033350557,0.016753824,0.020879207,0.08365315,-0.024077779,-0.044424374,0.007081129,0.009662493,-0.04384461,0.09482715,-0.042889517,-0.04839462,-0.043223087,0.00236538,0.003962731,-0.0008331589,0.0038178982,-0.038542412,-0.06232078,-0.036325764,0.034743328,-0.025685063,0.01863897,0.0941855,0.018515773,-0.08509258,-0.15185378,-0.009728143,0.03000334,-0.034039963,0.013831582,-0.0020844536,-0.014206457,0.007850285,-0.13765976,-0.012298244,0.034680173,-0.036281656,-0.03472125,0.038522135,-0.029447919,0.0007333994,0.021380275,0.00041838604,0.030776823,-0.0024650146,-0.04226929,0.10463337,-0.018022077,0.0058569144,0.03295436,-0.08189252,0.035300624,0.046713382,0.1707562,-0.09802193 +1.14.11.68,"Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.",384,1.0,-0.054395635,-0.044887632,-0.07013766,0.041908246,0.08352892,0.017232783,-0.019280238,-0.032991327,-0.07320655,-0.048544977,-0.004206678,-0.046060547,-0.022475256,0.018458957,0.03856988,0.061694868,-0.07813346,-0.04913159,-0.07275938,-0.000307542,0.036411542,0.07483059,-0.026263483,-0.03378916,-0.00814497,-0.037736624,0.09226025,0.016509205,0.035465907,-0.036103923,-0.00062007934,-0.021083118,0.03663077,-0.03551377,0.07588253,0.06354022,-0.036956437,-0.04210205,0.006513773,0.035307024,-0.028680464,-0.023566928,-0.06606739,-0.035754703,-0.068411596,-0.052822117,0.023044692,-0.044895995,-0.06353995,0.05828134,-0.03200959,-0.0029667157,0.002088027,0.051015608,-0.045644112,-0.060948152,-0.017578471,-0.00635134,-0.032525953,0.017839294,0.029102456,-0.025057904,-0.045337074,-0.028230257,0.047398485,-0.030514196,0.08073923,-0.053395517,0.02338308,-0.07446985,-0.040115274,-0.061565425,-0.08243174,0.0086829355,-0.016152434,-0.01583561,0.035354823,-0.05364996,0.06796681,-0.058138467,-0.052393697,0.029642785,0.07425107,0.11218347,0.05432791,0.016769342,-0.07919518,0.04576597,-0.0057054814,0.048648193,-0.02527809,-0.0009805541,-0.039856333,-0.017537586,0.02572385,0.06337001,0.10093195,0.05219273,0.02058911,0.038649924,-0.02466756,0.054131813,-0.08215444,0.032031573,-0.0084838085,0.022682099,0.017866533,0.047946353,-0.0016690155,-0.006649284,0.05085358,-0.0028550848,0.082205944,-0.01248832,-0.006954463,0.08694797,0.0839596,-0.021775411,0.010121385,-0.017624317,0.06448436,0.050984576,0.09689899,-0.0030984867,-0.019652264,-0.0028676274,-0.11673006,1.9876294e-33,0.05973408,0.07586272,-0.019706072,0.006485905,-0.052718252,-0.006149509,-0.13737202,0.03228251,0.0140407765,0.007871278,-0.012040909,-0.024904704,0.058156017,0.021239402,-0.07129077,-0.034107503,0.014105741,-0.034459416,0.030397851,-0.019444682,-0.011392991,0.0425267,-0.013657083,0.005285992,-0.03463015,0.03705355,0.04868008,0.055415705,0.014491337,0.0147893485,0.0059160423,-0.13824566,0.004918673,0.00023370098,0.052598733,0.06271287,-0.064166225,0.028677464,-0.018671649,0.031118218,0.07539578,0.044987474,-0.028269937,-0.06459319,0.005132203,-0.046332844,-0.034650736,0.08916535,-0.07383852,0.051706884,0.02925118,0.011057869,0.049828272,-0.07706572,-0.05880132,-0.0025073872,-0.0073336284,-0.010435119,0.08199533,0.06578339,0.04398929,-0.0055745086,0.011333592,0.10438712,0.07765182,-0.06363657,-0.087258294,0.03430073,0.008560224,-0.0059485254,-0.048194766,0.01262557,0.12199708,0.0044166856,0.003960473,-0.09050222,-0.09306254,-0.0016486648,0.038569886,0.01940811,0.041013315,-0.04040542,-0.04501304,-0.08146647,-0.08412149,-0.0038882396,-0.009154493,-0.082575396,-0.016643286,-0.06522504,-0.046439998,-0.05849951,0.0030872799,-0.03303883,0.027128013,-4.1140047e-33,0.041677743,8.589265e-05,0.0076539624,-0.07952975,0.017107474,0.017563414,0.06965488,-0.019001067,0.017018521,0.0020653969,0.10570467,0.009751344,-0.0034759233,-0.08678121,0.043591656,0.08512111,-0.0049679354,0.055331584,0.0339149,0.0017322376,-0.020874474,0.05802596,-0.055662964,0.07254451,0.029068174,0.048320495,-0.1082164,0.0150955655,0.11118352,0.09135825,-0.029517477,0.004238203,0.02366381,-0.09230634,0.0328771,-9.67482e-05,-0.053065974,7.390468e-05,-0.015935427,-0.0335086,-0.006088604,-0.057207163,0.04603933,0.14898291,0.032740306,0.08371542,-0.106347315,-0.032394413,-0.014716063,-0.018704409,0.0019641742,-0.039309613,-0.06392582,0.062031146,0.046118513,0.041459434,0.035610262,0.057485305,-0.0396691,0.049383845,-0.03845787,0.0034467143,0.010230686,0.034225356,-0.00945119,-0.0027564282,-0.09780051,0.010166622,0.0570455,0.023016067,0.052592367,0.012000193,0.037369784,-0.061532974,-0.051856782,-0.052787412,-0.008345164,0.015669726,-0.07061199,-0.017974982,0.05557399,-0.02980031,-0.0031000276,-0.002403251,-0.03288731,-0.1253771,-0.024923837,0.048285592,-0.035484135,-0.052456707,-0.031889394,-0.04109177,-0.060865086,0.06740292,0.04858485,-4.3624745e-08,-0.03328531,-0.13132513,0.04215019,-0.04234713,-0.033821497,0.0380044,0.04036439,-0.013575492,0.035251483,0.02862703,0.0072261873,0.069410436,-0.010001759,-0.031880118,-0.013900577,0.0016670655,-0.026862781,0.104451545,-0.045559786,-0.056583412,-0.03912446,0.0075222286,0.018281525,-0.002054909,-0.013876467,-0.027661206,-0.06501117,-0.023610856,0.0355092,-0.034079555,0.013884516,0.09921801,0.022893008,-0.07222768,-0.1394172,-0.0042442563,0.049936686,-0.036498252,-0.0032619361,-0.008091452,-0.0028850345,0.0127844615,-0.13907924,-0.007758447,0.040159598,-0.04374915,-0.040419642,0.04302043,-0.02784376,-0.0015878995,0.028459946,0.017125515,0.03616986,-0.0030754658,-0.051642276,0.10361219,-0.029311769,0.0079899905,0.016550874,-0.07524059,0.051519427,0.020858796,0.16956149,-0.09637092 +1.14.11.69,"Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys36 residues in the tail of the histone protein H3 (H3K36). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. Since trimethylation of H3K36 enhances transcription, this enzyme acts as a transcription repressor. The enzymes that possess this activity often also catalyse the activity of EC 1.14.11.66, [histone H3]-trimethyl-L-lysine9 demethylase. cf. EC 1.14.11.27, [histone H3]-dimethyl-L-lysine36 demethylase.",384,1.0,-0.040754635,-0.008699177,-0.087554045,0.000340121,0.11065903,0.027208757,-0.01685406,-0.035195418,-0.052149083,-0.051924095,-0.02467211,-0.021207675,-0.012382556,-0.0017778602,0.04207374,0.04883715,-0.09803991,0.016385771,-0.10852795,-0.059165813,0.01831498,0.048064332,-0.03441612,-0.036377855,-0.00035651223,-0.02369952,0.105906874,0.0049478207,0.0059712566,-0.04214418,0.0066026766,-0.053260412,0.06231396,-0.06023144,0.064038366,0.064648405,-0.05048556,-0.070748135,0.02068977,0.012621396,0.010754399,-0.018195026,-0.05021781,-0.016967252,-0.060536083,-0.02465046,0.027996343,-0.023728123,-0.026032547,0.047480255,-0.012106621,-0.0057229237,0.046047967,0.023078695,-0.06588407,-0.043802395,-0.006303683,0.02018941,0.0009769744,-0.016665796,-0.017194713,-0.06676271,-0.016284332,-0.043583278,0.043361615,-0.045162365,0.085349955,-0.037554797,0.03314319,-0.040919237,-0.040405158,-0.033827886,-0.04999989,0.04517496,0.01761907,0.0018586674,0.04364853,-0.016796002,0.0895571,-0.052967645,-0.06543662,-0.0077839037,0.09444085,0.09790141,0.008728646,0.006561344,-0.083412595,0.030473169,-0.014687398,0.0864752,-0.004685178,-0.03403386,-0.054837298,-0.0074104047,0.029957755,0.10534247,0.08461984,0.045344103,0.021998772,0.019042756,-0.020792603,0.04344754,-0.10255478,0.0444386,0.0014070175,0.03977917,0.0026607239,0.083542325,-0.0007354549,0.013309679,0.04242863,-0.028062355,0.09298032,0.0017037216,0.018856397,0.09369812,0.035019744,-0.030157179,-0.0059681823,-0.024986735,0.06174601,0.067523986,0.09275717,0.014517548,-0.010246485,-0.0012674992,-0.11913057,2.659949e-33,0.045896374,0.11259677,-0.027259665,0.0056420728,-0.04270016,-0.032250475,-0.11891376,0.04770084,-0.011731696,-0.021794027,-0.0052614785,-0.03125217,0.077516355,-0.015985325,-0.12202135,-0.042600263,0.035183515,-0.009894304,-0.0025440822,-0.0022393903,-0.000622497,0.023093032,-0.013282646,0.01713922,-0.0049023856,0.027035989,0.028571118,0.048599675,0.007856748,0.019831225,-0.026832717,-0.0959124,0.019737883,-0.015762372,0.07951858,0.04824384,-0.034685563,0.00768834,-0.053207587,0.06471071,0.095991135,0.03627412,-0.06098561,-0.06373196,0.00033416032,-0.06424881,-0.023376493,0.085211545,-0.047500394,0.035731126,0.02249937,0.019541034,0.106352136,-0.082911015,-0.06641726,-0.01826684,-0.035234947,-0.055781133,0.10455824,0.042892713,0.0146614835,-0.017331162,0.030168923,0.12436847,0.09805775,-0.024555715,-0.08552855,0.038021464,-0.017865013,0.033417325,-0.024730219,0.039572045,0.096558146,-0.017668623,0.01259456,-0.08062917,-0.11369834,0.015239058,0.022357222,0.03337873,0.033486996,-0.025878828,-0.049079806,-0.05921401,-0.085899204,-0.017947089,-0.016930431,-0.06187519,-0.00020503854,-0.021623129,-0.013127792,-0.07811838,0.0046399212,-0.020026403,0.030629352,-4.1577507e-33,0.059360173,0.007972777,-0.0048191366,-0.05527349,-0.007705171,0.024846831,0.09895774,0.016127884,-0.0087647345,-0.045439787,0.11697575,-0.0027046371,-0.022030702,-0.07468513,0.009876779,0.11845738,-0.0088277245,0.064908475,0.023221202,-0.018910253,-0.01577206,0.014110767,-0.09345708,0.115122,0.00083877187,0.03773573,-0.096798286,0.00789825,0.093750104,0.116737254,-0.016747087,-0.013103029,0.03125445,-0.06913463,0.031111985,0.0009767349,-0.06209627,0.010585364,0.010427609,-0.012576231,0.027261317,-0.046271864,0.03191693,0.0903261,0.05420853,0.09543958,-0.10496696,0.061701488,-0.0059189787,-0.019184636,0.025588797,-0.019456027,-0.05950546,0.09158938,0.040867638,0.023442004,0.060682517,0.076007195,-0.04146824,0.054480597,-0.06639271,-0.017332625,0.043815732,0.056489196,-0.0037716245,0.0077238423,-0.08487207,0.024582531,0.058691934,0.0026707274,0.019889815,-0.002314393,0.022788843,-0.06155258,-0.022740668,-0.010883755,-0.0038840596,0.0071834004,-0.09338106,0.010894094,0.0145550715,-0.04539992,0.012761115,-0.025569929,-0.022198703,-0.10690799,-0.019823514,0.071307726,-0.04846519,-0.04867773,-0.033854652,-0.052841157,-0.08004193,0.05552743,0.020939367,-5.038135e-08,-0.046789464,-0.08497882,0.026014835,-0.021507852,-0.033028957,0.07667961,0.064836994,-0.0014999422,0.032674115,-0.00017038315,0.001534184,0.030229373,-0.013069534,-0.059850197,0.004766526,-0.045051754,-0.03320122,0.05869411,-0.040842075,-0.06636019,-0.037338115,-0.012883621,0.003422623,-0.016712757,0.01366727,-0.029089794,-0.05473851,0.014109117,0.046726264,-0.07661481,0.004479244,0.06857602,0.0058914116,-0.05501751,-0.11150656,-0.004563527,0.049444534,-0.05356761,0.027272344,0.018920014,-0.0003034654,-0.0003650796,-0.12655702,-0.029230163,0.027922299,-0.03909414,-0.017257461,0.020352097,-0.041535772,-0.028306106,0.0027299405,0.025128417,0.042586032,0.008433295,-0.0149241295,0.09004634,-0.032125622,-0.014519278,0.014732268,-0.05981284,0.06918512,-0.021276196,0.12797719,-0.1032066 +1.14.99.66,"The enzyme specifically removes methyl groups from mono- and dimethylated lysine4 of histone 3. During the reaction the substrate is oxidized by the FAD cofactor of the enzyme to generate the corresponding imine, which is subsequently hydrolysed in the form of formaldehyde.The enzyme is similar to flavin amine oxidases, and differs from all other known histone lysine demethylases, which are iron(II)- and 2-oxoglutarate-dependent dioxygenases. The physiological electron acceptor is not known with certainty. In vitro the enzyme can use oxygen, which is reduced to hydrogen peroxide, but generation of hydrogen peroxide in the chromatin environment is unlikely as it will result in oxidative damage of DNA.",384,0.99999994,-0.033293277,0.029672973,-0.06605696,0.00097071263,0.08201565,-0.013094345,-0.07421508,-0.008354458,-0.072253264,-0.023944842,-0.01344705,0.033495784,-0.033578835,0.019101728,-0.007150078,0.13307181,-0.07180648,0.0012166245,-0.069784574,-0.04546279,0.0019305268,0.013329513,0.014870029,-0.075451754,0.029822627,-0.04669245,0.04676767,0.020159772,0.0074603828,-0.051416572,0.017634649,-0.031188177,0.07132655,-0.06476883,0.011738462,0.056930147,0.015892081,-0.015353173,-0.020587912,0.021236543,0.040656973,0.022146042,-0.09303249,-0.013457858,-0.013161477,-0.010155905,0.028124375,-0.049024988,-0.04196853,0.050800648,0.009667501,0.012873361,-0.0188071,-0.01220994,-0.06703338,-0.017314574,-0.041405406,-0.039599437,-0.03320024,-0.0026121677,0.0016557534,-0.043594174,-0.016511539,-0.007486395,0.06866742,-0.06784616,0.07289959,-0.08334377,0.034048878,-0.10337965,-0.0062517487,-0.07996364,0.028844764,-0.0470145,-0.025551995,-0.024198178,0.036011077,-0.049127422,0.031378172,0.0503527,-0.021853352,-0.05561259,0.08295067,0.0794444,0.054851916,0.022463176,-0.045973852,-0.0057281847,-0.037572913,0.08921541,-0.043872517,-0.016907357,-0.019677065,0.012198341,-0.0016394319,0.078592986,0.11177867,0.048611164,0.001299517,0.011229567,0.013349399,0.03518972,-0.09897913,-0.020802299,0.011053876,0.050722186,0.026703231,0.083789915,-0.011336071,0.0011171404,0.030171247,0.039448928,0.016619792,0.017024614,-0.014528708,0.109764054,0.073295,0.016382601,0.0015048361,0.032636743,0.0067284033,0.05684282,0.10042461,0.0107703665,-0.029906603,-0.012114779,-0.0799817,2.898344e-33,-0.016477097,0.08945848,-0.0776427,-0.02185499,-0.013951883,0.0033600195,-0.12452091,0.030823708,0.05108442,-0.018522114,0.0041630627,-0.01836977,0.08950356,0.03397099,-0.06567633,-0.032577533,-0.02644945,-0.02918805,0.009792919,-0.060129244,0.017594201,-0.018681861,-0.030115703,0.06915978,-0.0045152134,0.020375907,0.025304355,0.081543446,0.029321788,-0.004781537,0.013116272,-0.06732256,-0.017848266,0.010661224,0.0018626112,0.07808228,-0.063815966,0.022155007,-0.008203019,0.091186024,0.019531507,-0.0002628185,-0.05528734,-0.079081655,0.034298263,-0.07510977,-0.04901695,0.08161309,-0.023071611,0.0058085467,0.041472938,-0.03862549,0.069850765,-0.050467744,-0.049362384,0.006871256,0.016219392,-0.044584464,0.08590678,0.038599335,-0.028196445,0.0032235975,0.026638586,0.11233712,0.039535318,-0.032277822,-0.035169773,-0.040984854,-0.048386473,-0.026929026,-0.017968426,0.018085223,0.093294054,-0.02422077,-0.010272627,-0.049875848,-0.08430661,0.05382544,0.00468273,0.03894895,0.10753661,0.004883029,-0.047495846,-0.048959486,-0.011963735,0.002641074,0.022376606,-0.07906572,0.06899086,-0.017722413,0.067154214,-0.11326288,-0.0030776698,-0.080831,0.03137285,-4.2921446e-33,0.03047838,-0.007442408,0.027682163,-0.06939488,0.008161519,0.017338991,0.08212988,0.06389379,0.04378535,-0.025926368,0.028962279,-0.012468227,-0.015334957,-0.09801177,0.025508681,0.059997663,-0.015143812,0.028834395,-0.025394583,0.028718853,-0.0039936192,0.07202898,0.00036351234,0.08032429,0.04248614,-0.008075962,-0.08223891,-0.04187942,0.10154583,0.05459642,-0.07758035,-0.027481645,0.006681088,-0.015510952,0.07848365,0.025009375,-0.07657506,0.050417095,0.012821589,-0.010942927,0.0026952808,-0.0005212848,-0.0602365,0.06593828,0.019051202,0.14110583,-0.12107703,0.019708576,0.023862539,-0.045563277,0.026458906,0.0026685228,-0.02341263,0.021639973,0.081582166,0.0052253627,0.061011653,-0.032047704,-0.03744911,0.036342937,-0.049984403,-0.06359476,0.066914275,0.05121198,-0.024192886,0.034806073,-0.05986503,0.10338614,-0.01952248,0.02978146,0.02663086,0.015784279,0.043656792,-0.032031056,-0.019017821,-0.009596636,-0.046126112,-0.017736474,-0.11979546,-0.041796308,0.042149056,-0.023833726,0.026364045,-0.05580644,-0.012573237,-0.09586764,-0.018024983,0.09217753,-0.02577998,-0.052959047,0.024979215,-0.0025745854,-0.053698447,0.040697824,0.06381697,-4.2699845e-08,-0.005045251,-0.102200545,0.092514776,-0.029313669,-0.055729944,0.042860862,0.019782992,0.017085623,0.07764222,-0.015372639,-0.033828005,0.12447718,-0.032693125,-0.06040848,-0.022265067,-0.022610791,-0.031586684,0.043414794,-0.011572481,-0.06896295,-0.08676177,0.043912925,-0.035553325,0.021866713,0.025337506,0.029732974,-0.014920705,-0.026930103,-0.006006372,-0.06718485,0.018499505,0.067110665,0.046640888,-0.009522966,-0.15725431,-0.04257142,0.10849531,-0.027456684,-0.048745565,0.023506237,0.020427654,0.017401833,-0.11830304,0.0061178277,-0.0065224874,-0.0663251,-0.012175089,-0.007871805,-0.020242868,-0.014913581,0.054829665,0.027676119,-0.015510152,-0.066542506,-0.06644859,0.054279845,-0.057409123,-0.013303361,-0.0060953186,-0.07357039,-0.0017424835,0.014866004,0.18353398,-0.09672893 +2.1.1.354,"This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. EC 2.1.1.364, [histone H3]-lysine4 N-methyltransferase, describes enzymes that can catalyse only monomethylation of this substrate (the first sub-reaction of this entry); EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase, describes enzymes that catalyse only dimethylation of this substrate (the first two sub-reactions of this entry)",384,1.0,0.021298598,0.038594723,-0.076411285,-0.06757654,0.03790959,0.073911704,-0.06368804,0.010106969,-0.020813083,-0.068073496,0.018128289,-0.0373384,-0.029275164,-0.010951894,0.021693842,0.07846559,-0.1427514,0.010946779,-0.08770366,-0.10452944,0.043466922,0.055636987,-0.040172465,-0.03971855,0.022446161,-0.040927544,0.019524314,-0.0035844713,0.091043636,-0.039118566,0.033394504,-0.032928523,0.07936904,-0.04602532,0.07108132,0.06919753,0.0058487216,-0.05862894,0.055879485,0.013555923,0.05939455,-0.0008067691,-0.057154726,0.019113457,-0.05695799,0.016748503,0.024691131,-0.04426461,-0.043919615,-0.037581336,0.004418886,-0.011589309,0.0020492582,-0.020087954,-0.06921667,-0.009448347,-0.040388044,-0.009213516,0.05359352,0.009434644,0.029869083,-0.040914558,0.0118008,-0.03474009,0.0784752,-0.06820125,0.082817875,-0.07828283,0.027636161,-0.026958216,-0.058408365,-0.04093977,-0.031289287,0.05598487,0.020667307,-0.060194444,0.014615425,0.03803921,-0.010354627,-0.04329616,-0.025052857,0.026025454,0.022065083,0.03724567,-0.017009683,-0.0069476473,-0.08174753,0.04913876,0.056529082,0.05324711,-0.04600771,-0.08632113,-0.011561104,0.011129647,-0.041193943,0.12536858,0.05753784,-0.0102092,0.041032087,0.009473856,0.046875294,0.038104955,-0.15555128,0.050436758,0.046873234,0.07826926,-0.009975424,0.079164155,-0.053291228,-0.0074746883,0.0168713,0.016216617,0.038209856,0.034645136,-0.05324137,0.07068563,-0.0059509603,-0.03315475,0.024903206,-0.008178608,0.03276473,0.04714223,0.07421445,0.035021596,-0.04379714,0.018070333,-0.13338055,3.5388526e-33,0.051814422,0.10135762,0.0014880145,-0.0053845113,-0.015266224,-0.069297194,-0.060195323,0.025291713,0.0011297328,-0.075460106,0.013814636,-0.046198457,0.07260044,0.01743879,-0.09221431,-0.041075975,0.0027678262,0.032502275,0.0010069986,-0.020843035,-0.05669051,0.011318598,-0.019805893,0.06350632,0.019698068,-0.043591175,0.025533395,-0.008109773,0.08064286,0.014962413,-0.081109904,-0.075487845,0.049832024,0.0032316607,0.070964135,0.05616801,0.015303808,-0.018846009,0.030647717,0.07002314,0.007403742,0.020561198,-0.040176075,-0.07463382,-0.0033977977,-0.024512297,-0.04365339,0.06530869,-0.05859775,0.052754477,0.008780798,-0.03695046,0.1268568,-0.09712731,-0.06268801,-0.01641895,-0.03489922,-0.058852803,0.011711226,0.01649614,-0.059968088,0.003574955,-0.0052297562,0.07704402,0.043154,-0.04636732,-0.027788654,-0.025978005,-0.033057112,-0.0116013875,-0.063133396,-0.009510479,0.12845314,0.013981807,0.053081904,-0.07359807,-0.11035786,-0.022499487,-0.012790541,0.05911951,0.023623288,0.090291165,-0.03306328,-0.105203345,-0.026337361,-0.070204675,0.04376867,-0.11638023,0.026512275,-0.0044708233,-0.034621403,-0.067612775,0.03662727,0.023803566,0.015849777,-5.021439e-33,0.0479343,0.021103313,0.040035184,-0.027908457,-0.021161016,-0.0026536803,0.04996477,0.03913547,-0.016163602,-0.038093075,0.083295286,-0.015111671,-0.030827546,-0.09104861,-0.0061479234,0.030408375,0.029739572,0.07315727,-0.022525122,0.02386377,0.014597447,0.019134728,-0.07518558,0.1319144,0.017282145,0.013522395,-0.038668618,0.078250386,0.06164794,0.04773114,-0.06652982,-0.051971957,0.011051799,0.00044307992,0.039572682,0.04040989,-0.007735896,0.028220557,-0.015195674,-0.031224782,0.010269439,0.00393992,0.026121078,0.050891537,-0.008906565,0.091923706,-0.05817351,0.08531146,-0.02774924,-0.07302914,0.012938427,0.023521055,-0.03606268,0.07791504,0.04267518,0.045729756,0.06625148,0.042549822,-0.015799198,0.021511413,-0.054417226,-0.06491344,0.02817332,0.05451853,0.00068618223,0.007324386,-0.091864,0.021020934,0.019535258,0.03918669,0.029455088,0.02660047,0.051262926,-0.035236467,-0.041275956,-0.023537388,-0.0627842,-0.12389682,-0.1287283,-0.052551042,0.014116747,-0.05892749,0.034252144,-0.071114466,-0.013432391,-0.07205069,0.005482485,0.117939904,-0.036205396,-0.016027505,-0.0015381323,-0.027211027,-0.08054575,0.08338108,0.058538303,-4.6520306e-08,0.02515918,-0.066555336,0.018062316,-0.018310573,-0.032021176,0.09523864,-0.021014562,0.020857118,0.06851633,-0.023080708,-0.013941433,0.002273451,-0.046838503,-0.06220252,-0.040143996,-0.029295735,0.0009132451,0.06206539,-0.02071988,-0.035454027,-0.038241435,0.01557261,-0.017120272,-0.03165634,0.031053472,0.0034683244,-0.036430437,0.09398817,0.08087787,-0.088301525,0.060265098,0.03690829,0.031469554,-0.03342635,-0.058898076,-0.009282104,0.05077332,-0.06387658,0.0300231,0.026145583,0.0635203,0.013955273,-0.09754034,0.028501159,0.017138502,-0.015734956,-0.027073096,0.031455055,-0.02268624,-0.009284934,0.028799724,-0.0343495,0.0072298474,-0.0691762,-0.05678118,0.06919977,-0.07102802,0.0046441643,0.0047053825,-0.047434974,0.04363411,0.037847262,0.13465683,-0.04234704 +2.1.1.355,"This entry describes several enzymes that successively methylate the L-lysine9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, and EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase.",384,1.0,-0.015195205,0.024790531,-0.098100126,-0.06633825,0.05350441,0.08993813,-0.048134755,0.0012369574,-0.06418766,-0.08208734,-0.021626221,0.003424337,-0.025917588,-0.008203362,0.04556943,0.04087957,-0.13701835,0.033729363,-0.070438415,-0.11364636,0.030872867,0.11881763,-0.004473511,-0.040849473,0.02245549,-0.068078116,0.06641167,0.017445743,0.072358824,-0.037701663,-0.002757476,-0.0596486,0.033372708,-0.020535704,0.05857716,0.04162479,-0.019012408,-0.056104902,0.025202312,0.03475576,0.07197668,0.027416091,-0.04019045,0.0028618213,-0.043881968,0.013766623,0.018160073,-0.019699607,-0.06551991,-0.002859498,-0.008986812,-0.03463846,0.03650509,-0.019588182,-0.055765696,-0.015951056,-0.010915256,-0.016961029,0.050561838,-0.04156622,-0.02643301,-0.019717919,0.027319584,-0.024254002,0.0893397,-0.05217474,0.07574965,-0.06408354,0.0014795455,-0.014834783,-0.025424208,-0.039553136,-0.040950008,0.0049531306,7.961303e-05,-0.014757556,0.030519603,0.058412757,-0.0040898616,-0.04276964,-0.022057602,-0.022974543,0.059693955,0.044480428,-0.047025144,-0.030321274,-0.09232342,0.059058372,0.036961712,0.07805286,-0.026793912,-0.09528305,0.030063238,0.0063943323,-0.013075096,0.1037647,0.05301037,0.028684247,-0.003246398,-0.008810808,0.046999704,0.038197715,-0.12960522,0.07120793,0.08665453,0.07589684,-0.00012853151,0.06411242,-0.055733237,-0.0052131466,-0.0016243311,0.022595026,0.020207467,-0.0019464876,-0.053061225,0.028698584,-0.0015611568,-0.029493475,0.017633568,0.011876023,0.03734807,0.04857365,0.035110224,0.036406778,-0.049845196,-0.007534757,-0.13824244,3.0771487e-33,-0.0037089093,0.06323598,-0.031453226,-0.028118288,-0.010641087,-0.055023715,-0.10831517,0.02791546,-0.011071403,-0.08722175,0.019122107,-0.040386256,0.05887157,0.020168252,-0.08391405,-0.022352092,-0.016419368,0.030065265,-0.018663418,-0.030685335,-0.04920308,0.004057389,-0.02128279,0.03550555,-0.027038753,-0.0011073139,0.020268513,0.0330566,0.050600592,-0.011103379,-0.050319746,-0.060055915,0.09252687,0.0057949647,0.07181324,0.078097224,0.00066189136,-0.04444584,0.01754216,0.08581221,0.06239078,0.020782571,-0.06209798,-0.07420982,0.0037926675,-0.050933287,-0.008910621,0.016674506,-0.07921108,0.025603179,0.025720272,-0.016217913,0.09490995,-0.044576433,-0.022902463,-0.047713473,-0.029801616,-0.047016628,0.021104256,0.02380516,-0.058790565,-0.065633304,0.029007103,0.09829949,0.03432147,-0.041134246,-0.047918413,-0.0024391315,-0.028509606,-0.0067702434,-0.052433383,-0.0038626576,0.12892821,0.0048933774,0.030848388,-0.049627725,-0.1163832,0.008660122,-0.03211675,0.04543676,0.07609911,0.03555955,-0.05397379,-0.06944929,-0.035550248,-0.059011556,0.03113242,-0.10390713,0.0072885435,-0.01134534,-0.0026907208,-0.07176585,0.03496807,0.026847148,0.018375205,-5.2848933e-33,0.01912775,0.036853366,0.020037672,-0.05373709,0.013081688,0.0029607457,0.06557665,0.019339053,-0.03812023,-0.051081035,0.037548188,-0.050280973,0.011977776,-0.13481714,0.004868681,0.025235035,0.058071002,0.082455404,-0.039882027,-0.034745295,0.009467026,0.006678662,-0.08783391,0.12840198,-0.046597693,0.0029788865,-0.059795834,0.09460718,0.06094209,0.070459716,-0.08558369,-0.006008098,-0.010233505,0.015725346,0.05117754,0.011471087,-0.010263323,0.07391595,-0.0016396384,-0.0428743,0.04984994,0.018493721,0.0018268414,0.06207018,0.0044865594,0.15632418,-0.029708112,0.09452018,-0.014588013,-0.043702494,0.011588439,-0.007587035,-0.012109884,0.09021618,0.055218697,0.031350464,0.089671105,0.008127862,-0.0024212026,0.047836933,-0.07640038,0.02032951,0.041955665,0.07447749,0.009371143,0.011721298,-0.07770511,0.027416695,0.054150496,0.040670548,0.01198604,0.032694265,0.06898599,-0.014795288,-0.048411373,-0.022024216,-0.07091491,-0.04936772,-0.087965496,-0.035917632,0.02578211,-0.091973074,0.056328915,-0.029655546,0.018546535,-0.0478383,-0.0040938593,0.1033298,-0.012905929,-0.033566907,0.005717714,-0.020893302,-0.11292483,0.048099466,0.030423839,-4.5219956e-08,0.025860935,-0.120173916,0.013073069,-0.004697131,-0.020760821,0.07242762,-0.003543023,0.041176677,0.03564704,0.01788761,0.030949475,-0.039278403,-0.04248029,-0.08096276,-0.028902924,-0.040689886,0.0070271953,0.077581905,0.006945976,-0.040447198,-0.079768635,-0.0065036733,0.059412792,-0.022805115,0.034523822,0.022778193,-0.06242134,0.089909256,0.121662125,-0.07803833,0.06652981,0.010844582,0.020734493,-0.033771027,-0.07008687,-0.0118637085,0.08492594,-0.064884044,0.063091956,0.05699535,0.047840144,0.030809132,-0.074321695,0.017791066,-0.0041854614,-0.009472489,-0.027044177,0.045013785,-0.0429215,-0.057719328,0.019510197,-0.014489404,-0.010916967,-0.07173706,-0.023038061,-0.008934633,-0.08210062,-0.019583357,-0.00055164745,-0.0028978207,0.010127693,0.021196153,0.100872785,-0.05192414 +2.1.1.356,"This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. The methylation of lysine27 leads to transcriptional repression of the affected target genes. The enzyme associates with other proteins to form a complex that is essential for activity. The enzyme can also methylate some non-histone proteins. cf. EC 2.1.1.369, [histone H3]-lysine27 N-methyltransferase and EC 2.1.1.371, [histone H3]-lysine27 N-dimethyltransferase.",384,0.99999994,-0.015024098,0.0014824574,-0.10443402,-0.035055466,0.016049583,0.087850675,-0.052750655,-0.028325306,-0.04099247,-0.035821013,-0.0003142352,-0.011749075,-0.0083554145,-0.024917929,0.043675255,0.045107316,-0.14962897,0.007479878,-0.037053745,-0.10590778,0.019521559,0.0829946,-0.0088277105,-0.0075965323,0.008378653,-0.021340424,0.034263767,0.01404885,0.08096066,-0.04746025,0.025291072,-0.055026934,0.050754122,-0.033588886,0.075758845,0.040394213,-0.03577569,-0.047968008,0.058196723,0.015108634,0.02511289,0.01245545,-0.041049726,0.0034638103,-0.049077243,-0.02305907,-0.018784396,-0.04380756,-0.064345144,0.018948957,0.00824283,-0.05652235,0.04061995,-0.0070733544,-0.04036878,0.03363605,-0.044563398,0.017103378,0.076028116,0.011128425,0.0070805876,-0.04652731,0.0124905305,-0.043836944,0.05678096,-0.12965,0.06280973,-0.034256525,0.03954628,-0.03468661,-0.037701663,-0.04605261,-0.015910164,0.05836391,0.014686933,-0.026066415,0.0121010635,0.034028612,-0.0028309377,-0.04015393,-0.035842083,-0.04011195,0.036736403,0.07319604,0.021729333,-0.0602895,-0.05001904,0.06669035,0.080134764,0.053824574,-0.01790519,-0.07169702,-0.024619762,0.017263066,-0.025490617,0.080654085,0.06562539,0.009629677,-0.023514166,0.02797144,0.07018184,0.04122595,-0.10755692,0.042614494,0.049632885,0.08570269,-0.010923991,0.06600151,-0.048855793,0.0126040755,0.020414297,0.038445428,0.045632236,0.003425305,-0.010165778,0.084681004,-0.007480237,-0.039554205,0.04318084,-0.004752438,0.025481962,0.030489517,0.05559218,0.02880711,-0.070392706,-0.03455111,-0.14026377,2.087415e-33,0.025639448,0.06389614,-0.04265028,-0.0010431587,-0.023659362,-0.021722734,-0.039903868,0.030764831,0.02250329,-0.07684369,0.033509336,-0.030837042,0.085903294,0.00890008,-0.10147646,-0.0015437116,-0.01272307,-0.02925456,0.00089505775,-0.0368033,-0.028968591,-0.02268783,-0.041186173,0.0082708625,-0.023474205,-0.03785346,0.027054064,0.03705949,0.055293936,0.022300096,-0.04505999,-0.093657844,0.06802711,0.03406776,0.07816632,0.025018647,-0.010860481,-0.042201065,0.02061908,0.07297126,0.063340634,0.012627792,-0.035460472,-0.0634944,-0.009903293,-0.015102979,0.045506008,0.065093435,-0.089480996,0.041521337,0.060040977,-0.029144166,0.06416056,-0.08072493,-0.04109732,0.03608023,-0.019635508,-0.0441924,0.029784134,0.032279722,-0.03349419,-0.06053006,0.05538542,0.10617199,0.08363866,-0.027351659,-0.05283302,-0.0034571516,-0.068864435,0.005085227,-0.06803374,0.018066699,0.11733265,-0.027443212,0.0012364656,-0.080144204,-0.15852971,-0.003373465,-0.04324082,0.045285754,0.050861526,0.013542219,-0.059286147,-0.071783,-0.05973798,-0.062419247,0.011758326,-0.114794254,0.0076239104,-0.02712669,-0.011888205,-0.10938093,0.02316645,0.06267586,0.014392499,-3.763078e-33,-0.0042201634,0.03719483,0.06977267,-0.06683328,0.017660163,-0.017440643,0.10852758,0.030797224,-0.025062162,-0.035593435,0.051966924,-0.013875863,-0.029569076,-0.11332451,-0.004281952,0.045676567,0.02083446,0.0748783,-0.023238277,-0.012713052,-0.008777281,0.0078867255,-0.078929506,0.14222088,-0.054434136,0.050682727,-0.065970734,0.04187373,0.08998356,0.08514741,-0.037636027,-0.03129799,0.020488817,-0.026079064,0.026307262,0.03504589,-0.04937239,-0.024937216,0.002222788,-0.058824714,0.010081459,-0.025525073,0.00012950867,0.04422152,0.0010722596,0.11302652,-0.0028469858,0.056917377,-0.014262046,-0.07927726,-0.0076743527,-0.020173986,-0.020466905,0.08717833,0.0316458,0.00782017,0.05263771,0.0056380965,0.012596872,0.048177853,-0.009790674,-0.0045896624,0.0107407,0.067074634,-0.014122991,0.011948021,-0.10469348,0.024260921,0.07270366,0.0872483,0.027822247,0.013887989,0.015514572,-0.009670531,-0.059727855,-0.05014153,-0.024481867,-0.058880225,-0.11370823,-0.07241529,0.031095093,-0.0805765,0.017917383,-0.055756886,0.030896269,-0.046263743,-0.03212422,0.0647443,-0.026054783,0.025066495,-0.0044917846,-0.0129658785,-0.10866163,0.08339416,0.03762167,-4.0080856e-08,0.0139812585,-0.11785992,-0.010492934,0.012746932,-0.024363386,0.07991295,-0.02234667,0.05181197,0.035017323,0.032673005,-0.017620094,-0.029588444,0.008391586,-0.044079017,-0.054987136,-0.012772385,0.02700279,0.08313674,-0.023169424,-0.056704633,-0.0049239397,-0.011477668,0.07134632,-0.016448403,0.0329311,0.0028144582,-0.051813282,0.13724911,0.06311465,-0.0632463,0.048794735,0.010540527,0.0347515,-0.01713725,-0.06037883,0.0607111,0.08176773,-0.095470086,0.00892224,0.013072514,0.05384134,0.04838845,-0.11074076,0.02572377,0.026146809,-0.03407704,-0.031145055,0.03197662,0.0072499844,-0.00839608,-0.0060679372,-0.0066962237,0.010830453,-0.05368924,-0.022561293,0.040149134,-0.10185156,0.0023968783,0.018152358,-0.030693155,0.03658454,-0.005295172,0.106186844,-0.071955204 +2.1.1.357,"This entry describes a group of metazoan enzymes that catalyse two successive methylations of lysine36 of histone H3 (H3K36), forming mono- and dimethylated forms. These modifications influence the binding of chromatin-associated proteins. Some enzymes can catalyse three methylations, forming a trimethylated form; these enzymes are classified under EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase.",384,1.0,0.030501654,-0.00040293185,-0.11965163,-0.09865605,0.018284798,0.018214593,-0.05695317,-0.014970369,-0.054261915,-0.022749102,0.018422121,-0.019960241,-0.07580303,-0.011050819,0.049432114,0.058336865,-0.16222575,0.050206266,-0.09302853,-0.07222506,0.03090863,0.069877505,-0.007152032,-0.017135166,-0.0016138572,0.00013299682,0.01741161,0.013176879,0.04722184,-0.03424802,0.047603946,-0.021560824,0.07144907,-0.06067427,0.100538105,0.032758854,-0.042447448,-0.03533158,0.0481551,0.013352212,0.027962718,-0.012405247,-0.035470158,-0.042192075,-0.059955925,-0.015459968,-0.005415639,-0.0185176,0.02497128,-0.0056374064,-0.026018048,-0.021485109,-0.02001015,0.025667347,-0.10956364,-0.026080852,-0.06574329,-0.042462263,0.03825154,0.008817899,0.002440358,-0.01708244,-0.00799598,-0.021829592,0.08358036,-0.03948588,0.02730858,-0.048043706,0.024464952,-0.04833646,-0.023083476,-0.06111643,-0.031883862,0.034138493,0.023338672,-0.0005116442,0.022781149,0.005566009,0.020822348,-0.04063691,-0.044799305,0.006891687,0.042911295,0.09988939,0.004497958,-0.038473427,-0.06246039,0.06827433,0.07062882,0.04224211,0.0105679585,-0.028504469,0.0069838795,0.016987333,-0.048364617,0.089767456,0.07015207,0.04360334,0.041008357,0.026007874,0.06547783,0.008645209,-0.10248174,0.036580965,0.03217136,0.08106589,-0.0070431503,0.10084526,-0.06762381,-0.02322942,-0.0015557973,0.011124929,0.044719387,-0.023476297,0.010665335,0.07060469,-0.019055504,-0.019904563,0.052975535,0.007156592,0.024258101,0.05012841,0.07086528,0.0016550687,-0.011118248,0.016453966,-0.16527908,4.224057e-33,0.013706978,0.13675812,0.0079343775,-0.033055495,-0.008267969,-0.025665453,-0.08176604,0.043385573,-0.024329891,-0.07973635,-0.0201517,-0.040698007,0.075225644,-0.032468483,-0.09978059,-0.046810027,0.0013627544,0.019472376,-0.0068374746,-0.005896002,-0.017910017,0.036009695,-0.016948506,0.007879623,-0.0017143155,-0.010216993,0.0146321375,0.017905315,0.03440592,0.04022515,-0.058240876,-0.10462821,0.042136542,0.025390496,0.045756377,0.0705248,-0.017126407,-0.0054488983,-0.0077649364,0.072817355,0.03451258,0.0076366295,-0.07215505,-0.05639223,-0.03003349,-0.03528525,-0.032945167,0.08030161,-0.03702809,0.040729377,-0.0071162186,-0.04407361,0.06926769,-0.048719842,-0.05797559,0.00061291666,-0.048180245,-0.024194004,0.056449234,0.013737707,-0.033073224,-0.011120809,-0.0005211257,0.12127326,0.026283504,-0.07140876,-0.016934253,-0.026269773,-0.022927456,0.049006898,-0.0859369,0.02230028,0.09286204,0.00025170165,0.04104276,-0.088712715,-0.08658769,-0.08337573,-0.013313201,0.072695136,0.01796044,0.056517113,-0.0667798,-0.0356718,-0.049864057,-0.046902332,-0.016697455,-0.096366175,0.019171612,-0.0053189937,-0.022636002,-0.13435262,0.03668138,0.02533297,0.028585577,-5.154467e-33,0.023791762,0.026193155,0.0439867,-0.052778564,-0.0015346698,-0.020679835,0.08347353,0.02102919,-0.023320293,-0.0219072,0.07965541,-0.007897468,-0.025591638,-0.10569772,-0.0075335354,0.059707582,0.07690817,0.033728797,0.039976027,0.016188055,-0.007672331,-0.0005369738,-0.08238413,0.1468982,-0.031531405,0.04242797,-0.018909365,0.016104663,0.08466023,0.072691575,-0.03919049,0.0037213622,0.0061962605,-0.050534938,0.022748979,0.082532085,-0.04225421,0.010145549,0.011304737,-0.01575154,-0.027477205,-0.009530506,0.049062785,0.06499641,0.012248683,0.10649574,-0.034967758,0.07976332,-0.014274842,-0.093726404,0.033397388,-0.0019307042,-0.029645344,0.072876334,0.06103896,-0.0062973956,0.0463434,0.04020773,-0.05501133,0.046091016,-0.019789834,-0.054372687,0.032950707,0.016842669,0.04086209,0.0077517345,-0.05515498,-0.028272236,0.023562232,0.05219093,0.04704181,0.015131237,0.025085017,-0.014744702,-0.02583725,-0.0047319448,-0.06537021,-0.06348635,-0.11139251,-0.032719564,0.06925266,-0.056278992,0.05721204,-0.06105295,-0.057861313,-0.101458244,-0.012080445,0.13880683,-0.05793947,0.016979266,0.023154173,-0.008243863,-0.058278665,0.10661076,0.026470788,-4.083302e-08,0.033660952,-0.10392087,0.011081946,-0.0041762423,-0.051487092,0.13475777,-0.018914277,0.012712714,0.093787156,0.003820042,0.012302608,-0.0028735877,-0.016456444,-0.030234553,-0.058165647,-0.036945045,-0.01732197,0.07421028,-0.032547873,-0.047815587,-0.026657775,0.04821933,-0.008393561,-0.06027089,0.025341624,-0.0030855949,-0.070524305,0.0714316,0.05844663,-0.052260444,0.029194044,0.041173574,0.052074,-0.030672507,-0.06897399,-0.0228551,0.033442385,-0.07075488,-0.025887335,-0.016264383,0.09259843,0.007826963,-0.10567593,0.0084502185,0.0034133524,-0.010958301,-0.03998073,0.06462696,-0.017449562,-0.013547619,0.009971235,-0.013494921,0.02335602,-0.04009656,-0.028709523,0.063739166,-0.07464184,-0.014102401,-0.021626899,-0.075417966,0.037981518,0.02352017,0.10946158,-0.060913514 +2.1.1.358,"The enzyme, found in metazoa, methylates a dimethylated L-lysine36 residue of histone H3 (H3K36), which has been methylated previously by EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase. The homologous enzyme from yeast catalyses all three methylations (see EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase).",384,0.99999994,0.018811198,0.018813003,-0.12803875,-0.064438075,0.06663939,0.03312351,-0.0661732,0.0014212158,-0.049443133,0.006425037,0.04455549,-0.017101727,-0.106691696,-0.016545929,0.00789307,0.056629755,-0.10293898,0.028184747,-0.05938046,-0.057023104,0.05764894,0.08635954,0.03436648,-0.01462482,0.011615843,-0.0045223203,0.017841853,-0.0034149864,0.020236505,-0.09584995,-0.008197334,-0.011949714,0.043468304,-0.05355686,0.092222184,0.043718003,0.0030849497,-0.020251956,0.0664051,0.014261958,0.011715949,-0.026374694,-0.042857636,-0.043144073,-0.061189223,0.026751455,0.004871174,-0.03151097,0.064467326,-0.011082835,-0.040340375,-0.0510686,0.01622685,0.018420525,-0.082194395,-0.01704943,0.013157147,-0.046638288,0.015397073,0.0142666325,0.0017833416,0.007016733,-0.016693916,-0.01868672,0.04989654,-0.03732205,0.056996558,-0.07064763,0.017819943,-0.055751964,-0.05780973,-0.089709155,-0.028846364,0.044126548,0.06662688,0.02130685,0.047454048,-0.008514623,0.025636565,-0.032976195,-0.01803963,0.007779249,0.047898274,0.041839615,0.026973555,-0.0404371,-0.050939824,0.07912337,0.13804975,0.0364703,-0.021170504,0.020725073,-0.024381291,0.018479083,-0.041558847,0.09028575,0.022780435,0.10252146,0.055404544,0.002410156,0.08042306,0.035982184,-0.09236056,0.025529347,0.027739288,0.11801213,0.0065437513,0.11574754,-0.020557102,-0.008062652,-0.0013763031,0.006950463,0.058090765,-0.01167453,0.015154961,0.030753244,0.008779791,-0.007010131,0.026035195,-0.02241116,0.036088634,0.054310203,0.077194996,-0.0034165834,-0.03289659,0.013783824,-0.15552029,4.0541375e-33,0.012054721,0.16361149,-0.028971529,-0.0411085,-0.021138446,-0.00023021553,-0.058674082,0.042842083,-0.040523265,-0.07080111,-0.04895545,-0.020710213,0.0061531183,-0.024901196,-0.10115589,-0.03482153,0.052597653,-0.0071935807,0.00790932,-0.03061515,-0.0014553592,-0.0009083994,-0.039599515,-0.007882961,0.019674322,0.018503694,0.057365086,0.03200284,0.03414653,0.006488832,-0.062176105,-0.10847311,0.048199583,0.019142045,0.058438405,0.041692562,0.008268949,0.0076392004,-0.01614936,0.07410873,0.044764638,0.04220568,-0.016903698,-0.036715783,-0.037830647,-0.012898111,-0.055627402,0.05217418,0.028512368,0.034267846,-0.012769788,-0.04698039,0.06156309,-0.027102236,-0.05366322,0.011843748,-0.03511701,0.010235373,0.056301415,-0.0027397396,-0.05894716,0.022327337,0.016725842,0.12350959,0.044059295,-0.08530467,-0.04431253,-0.021246668,-0.056889504,0.03433719,-0.089014895,0.00046425863,0.079929106,-0.0020493877,0.044376336,-0.1296164,-0.101921715,-0.0817906,-0.0112757,0.04714429,0.040529,0.007924429,-0.06873253,-0.04939971,-0.06659673,-0.012060821,-3.381379e-05,-0.08285395,-0.013206303,-0.030515153,-0.012060878,-0.112322055,0.05877794,0.01973572,0.033902235,-5.4763068e-33,0.03678622,0.0232288,0.07769357,-0.058409005,-0.04619984,0.024332738,0.0848598,0.0133522665,-0.062259234,-0.047228757,0.05751715,-0.030031752,0.0072725723,-0.096619755,0.0406363,0.05157403,0.034797043,0.04286007,0.03854767,0.027288398,0.010521355,0.020336656,-0.07613566,0.12430916,0.006812789,0.007518692,-0.016900681,0.060003277,0.08606393,0.036758892,-0.044043697,0.025787042,-0.00031732128,-0.08718368,0.029158661,0.058809932,-0.06965987,-0.03268856,-0.0020005614,0.028791253,-0.004725919,-0.017448926,-0.009557735,0.04390976,-0.008324865,0.13582355,-0.0845667,0.06395531,0.019345416,-0.075503655,0.017978119,-0.008369242,-0.030757196,0.0129741365,0.072233535,0.008073976,0.04622722,0.04520719,-0.0392433,0.013640647,-0.00942425,-0.036931396,0.008353898,0.0065848525,0.022987513,0.060015872,-0.07087494,-0.037402105,0.021188239,0.07337838,0.052814875,0.021176767,-0.01659714,0.013471703,-0.051154546,-0.012142994,-0.08471476,-0.061211128,-0.086299285,-0.030120041,0.09627021,-0.047166325,0.09313822,-0.06053334,-0.048484493,-0.110716864,0.012746102,0.10242013,-0.073561355,0.035087403,0.020845616,-0.012907189,-0.0857004,0.08470906,0.032578226,-4.411816e-08,0.0342395,-0.073078595,0.044323545,-0.049802557,-0.022342006,0.0922156,0.0058303,-0.0016349349,0.08217101,0.019656768,-0.0518401,0.018434783,0.01807003,0.01666811,-0.030298155,-0.026908185,-0.017619777,0.09107692,-0.010665971,-0.03354525,-0.038665857,0.040200677,-0.037417166,-0.064696305,0.01420799,-0.0035082924,-0.009646982,0.087278984,0.053979937,-0.09218701,-0.0014181287,0.031887233,0.059582844,-0.03342147,-0.046425924,0.003804864,-0.012708021,-0.07732968,-0.0333285,-0.048046485,0.07047038,0.0034676925,-0.0910408,-0.0004291755,-0.024122018,-0.025412252,0.0018008342,0.06776456,-0.02842919,-0.017541803,0.03189196,0.008197164,-0.030239008,-0.053823233,-0.0435037,0.010583422,-0.062022924,-0.025795678,-0.022698712,-0.085049465,0.038836963,-0.03780264,0.0871463,-0.07695263 +2.1.1.359,"The enzyme, characterized from yeast and mammals, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. cf. EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase.",384,1.0,0.03932846,0.005562666,-0.07537287,-0.07754111,0.012041362,0.06892065,-0.08469525,-0.037619114,-0.05953674,-0.019937394,-0.012126206,0.0030208144,-0.045113564,-0.0336933,0.037171684,0.08298249,-0.14843006,0.044914108,-0.06602119,-0.09066277,0.03421774,0.08132484,-0.027928803,-0.051410794,0.010730986,-0.019887988,0.035621084,-0.018615745,0.057459082,-0.032344453,-0.019107243,-0.034021076,0.08431953,-0.03424106,0.06335918,0.075976074,-0.005557722,-0.06666624,0.057286706,0.0307249,0.072947636,-0.006764212,-0.06187287,0.0009460786,-0.076336525,-0.0018403535,0.0025909569,0.0018458049,-0.019840123,0.011951876,-0.016236393,-0.025575057,0.012259417,-0.05334698,-0.10086242,0.011934877,0.008439315,-0.013291223,0.08585061,-0.024533344,0.00528814,-0.04088814,0.020259308,0.010230779,0.07276828,-0.11370074,0.09878589,-0.020505339,0.007914974,-0.021163026,-0.023167837,-0.057354186,-0.05543822,0.060366794,0.019207599,-0.07309141,0.017108656,-0.014289188,0.037207384,-0.03027303,-0.050363638,-0.0358165,0.06485,0.04616632,0.015791403,0.002126879,-0.05572042,0.0624186,0.08003867,0.05496264,-0.005676202,-0.06305714,-0.057506718,0.024773017,-0.025364472,0.08315665,0.045228317,0.017483585,0.002889738,-0.008575882,0.061657052,0.033405885,-0.106824026,0.032847546,0.06351906,0.09356874,-0.0053627132,0.041931428,-0.059138242,0.030369164,0.004099453,0.036832336,0.040747516,0.01241109,0.008457518,0.038208,0.0013451282,-0.0076964214,0.019295007,-0.017732516,0.026824884,0.04260615,0.036152177,0.036486465,-0.0651134,-0.053639963,-0.118957914,1.870212e-33,0.014600981,0.09474313,-0.030673299,-0.01764759,-0.0032953862,-0.019782605,-0.050764576,0.05268532,-0.06276406,-0.06917781,0.0024382542,-0.037064843,0.07115797,0.009585429,-0.10213929,-0.029695695,0.023694998,0.037147798,-0.010813616,-0.05052377,-0.04312239,0.008893351,-0.031351212,0.05694579,0.008627369,-0.015595437,0.05029173,0.021530613,0.06615972,0.0016950535,-0.056468826,-0.064249955,0.041076846,0.031395704,0.07595182,0.019852607,0.00048327624,-0.012502537,-0.010400995,0.09124851,0.047610775,0.01740041,-0.03815877,-0.07009763,-0.03494816,-0.024616921,0.02312261,0.03157244,-0.06466032,0.03621949,0.011410079,-0.018120913,0.08715017,-0.058567323,-0.032463025,-0.012437459,-0.04721864,-0.05331393,0.018494712,0.010654932,-0.06941811,-0.027226092,0.06852783,0.12839858,0.06272361,-0.061454732,-0.049424537,-0.05863155,-0.026294345,0.034689914,-0.04610671,0.0018564372,0.09104526,-0.0357305,0.019948356,-0.08019678,-0.14289322,-0.06391552,-0.030266222,0.062719174,0.056156233,0.011873452,-0.06357339,-0.0544412,-0.058489684,-0.06059165,0.021261647,-0.10046646,0.029239595,-0.0058967927,-0.016165892,-0.11899716,0.069184236,0.032375198,0.0616871,-3.730509e-33,0.02969615,0.008733539,0.10018709,-0.03399413,-0.029003123,-0.039258722,0.09277179,0.03133464,-0.0465481,-0.044907313,0.060121316,-0.008820352,-0.031856887,-0.07785145,-0.0038219315,0.085332215,0.06957863,0.0627538,-0.018341105,-0.021929637,0.010960363,-0.0038422626,-0.07722141,0.15820463,-0.0070739533,0.02700105,-0.041471835,0.012518402,0.08898276,0.033575166,-0.052878357,-0.015558055,0.031029524,0.005858244,0.061006643,0.060345218,-0.05304727,0.01987828,0.011023525,-0.014438415,-0.0044539175,0.011377362,-0.00410002,0.052119873,0.020653578,0.087830044,-0.015518888,0.08217135,-0.014846255,-0.08023927,0.021433573,-0.0029691623,0.002589072,0.07124122,0.057788562,-0.011257558,0.063770585,0.027155425,-0.057968408,-0.0008548731,-0.050223812,-0.032171406,0.023986805,0.054788858,0.013676712,0.017314846,-0.058252953,0.017419888,0.027415393,0.035626344,0.040460378,0.038648315,0.050404947,0.012537282,-0.049071293,-0.051238146,-0.033213157,-0.08616944,-0.12208539,-0.04111562,0.020932699,-0.059999336,0.044333134,-0.06023744,-0.062303536,-0.093951344,-0.0005197105,0.09494772,-0.040944587,0.025866184,0.0038598755,-0.013343736,-0.088725924,0.087874986,0.044444576,-4.0640526e-08,0.01691342,-0.07825559,0.018323895,-0.022475574,-0.021183994,0.109634385,0.014949905,0.025223013,0.060211577,0.036566403,-0.020926135,-0.022379907,0.006861287,-0.036464795,-0.017257143,-0.033420753,-0.060091734,0.047928184,-0.0034105468,-0.027952544,-0.0033264433,0.038104713,-0.021988768,-0.008146489,-0.007262345,0.02075462,-0.049028832,0.092889324,0.07040898,-0.0827065,0.036077052,0.03921663,0.04695586,-0.016685853,-0.07941123,0.00016624451,0.08184472,-0.08219711,0.009686487,0.017122783,0.08668625,0.020006504,-0.06881914,-5.125818e-05,0.0006405757,-0.026693542,-0.021822842,0.04614759,0.011489174,-0.013966416,0.0067865355,0.030166073,0.001848701,-0.04556355,-0.015552305,0.044011083,-0.112486675,-0.012849345,-0.020659793,-0.036117632,0.0003671508,-0.014743231,0.115699194,-0.1266232 +2.1.1.360,"The enzyme successively methylates the L-lysine79 residue of histone H3 (H3K79), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. This is the only known methylation event of a lysine residue within the core region of a histone, as all other such modifications occur at the tail.",384,1.0,0.011383877,-0.0011659343,-0.058394343,-0.07053121,0.07590236,0.08773708,-0.011121711,0.023586113,-0.07967544,-0.036920976,0.011957319,-0.014110743,-0.04769923,0.007381225,0.015212971,0.056564283,-0.12211634,0.00011799582,-0.056839462,-0.085552864,0.039089102,0.08315442,-0.03450003,-0.026788523,0.04606871,-0.04414351,0.053215906,0.031881776,0.09463841,-0.035118636,-0.041328687,-0.021892637,0.05736394,-0.018975075,0.071132995,0.04731077,0.0008103816,-0.03912915,0.07204953,0.017898075,0.08339647,0.01035833,-0.039558742,0.0073725055,-0.08662981,0.0057083294,0.04891084,-0.022640996,-0.06262318,0.016969442,-0.005400449,-0.046927534,0.019493729,-0.019241257,-0.113529555,-0.036301896,0.005617109,-0.04361888,0.049936052,-0.024128009,-0.023367723,0.00032852104,0.0037491778,-0.016125377,0.10999836,-0.11073246,0.07656385,-0.06827525,0.011967476,-0.025461907,0.044605736,-0.04953118,-0.03781627,0.03299962,0.030899033,-0.0030847953,0.00040234867,0.0114386575,-0.0158993,-0.06397396,-0.030318378,-0.022635678,0.08510718,0.08107594,-0.002962745,-0.010022471,-0.08043772,0.060687173,0.02999242,0.02105468,-0.00092179095,-0.07651299,-0.035900097,-0.012504025,-0.031829778,0.07138298,0.080623634,-0.010963813,0.016618136,0.038744427,0.035465203,0.025199566,-0.124890536,0.07318464,0.0852192,0.07093131,-0.032600667,0.038709726,-0.062171053,-0.0308086,0.024441445,0.035889264,0.07781124,0.001464721,-0.028516943,0.018861307,0.025117192,-0.0049973833,-0.010059988,0.015526083,0.031012362,0.050986487,0.053950522,0.048653465,-0.065784596,-0.045152005,-0.15783899,1.277184e-33,0.029054895,0.049855508,-0.023483187,-0.067617536,-0.041061126,-0.054893788,-0.100021556,-0.010109406,0.011204013,-0.07393229,-0.0066456087,-0.024062784,0.0867128,-0.034377977,-0.122810304,-0.028369103,-0.017169839,0.02241104,-0.014879648,-0.03551792,-0.07563227,0.0020572587,-0.034899335,0.0589698,-0.0058169984,0.031035643,0.0113162175,0.039887536,0.06374317,0.013754809,-0.045846887,-0.03938376,0.07647788,0.04173054,0.05909507,0.07990197,-0.010157671,-0.05067095,0.009326398,0.080336355,0.08353415,-0.007695622,-0.04252048,-0.07853215,-0.04742759,-0.05477705,-0.025343578,0.087520234,-0.07288779,0.0061889985,0.043082133,-0.021634689,0.053371422,-0.06316196,-0.04422118,-0.00048890535,0.024333008,-0.054695774,0.034648687,0.021210713,-0.0056740046,-0.047438685,0.01524259,0.08589258,0.048951004,-0.04759044,-0.032098632,-0.021122346,-0.013836156,-0.027327945,-0.06379575,0.007490667,0.13591978,-0.005775527,0.0047206027,-0.04758356,-0.13248752,-0.021904727,-0.024943726,0.028023282,0.075780354,-0.0033964526,-0.060443792,-0.056773327,-0.06588388,-0.045683313,0.058474008,-0.10138244,-0.034698423,-0.032338586,-0.018508868,-0.071930006,0.064000994,0.008680525,0.009714968,-3.375018e-33,-0.005005633,-0.004552674,0.055583544,-0.013822952,0.02240778,-0.02489744,0.09958603,0.008487347,-0.07950873,-0.04169565,0.07348865,-0.044723466,-0.038444508,-0.08892769,0.010228869,0.08925897,0.03383709,0.07868531,0.006871518,-0.01711433,-0.012595464,-0.027584253,-0.005611817,0.12122163,-0.009178903,-0.0077483766,-0.07329753,0.01559799,0.06484742,0.05076786,-0.06707016,-0.034003187,0.026012396,-0.034659117,0.028080938,0.03325609,-0.040143557,0.008106235,0.027081497,-0.039617673,0.02941274,-0.021740234,0.026519926,0.047921807,0.018221028,0.1019065,-0.05376644,0.080689386,0.0047405013,-0.088465035,0.014774926,-0.0041631083,0.016375607,0.06799164,0.01856542,0.10167306,0.054991342,0.03317299,0.008051387,0.044264313,-0.041146368,0.004340063,-0.0073322654,0.061887525,0.029528668,-0.005670005,-0.072289094,-0.007673,0.020211613,-0.0028917482,0.034532685,0.034943223,0.0741309,0.016537588,-0.031690504,-0.038971484,-0.041836385,-0.08058122,-0.13077047,-0.066628516,-0.0066983392,-0.036004353,0.026126819,-0.021474147,-0.0008762528,-0.058887064,-0.056577947,0.10805112,0.0155787915,-0.06391184,-0.0028582562,0.02411772,-0.08769004,0.05515799,0.058407277,-3.7454193e-08,0.044587005,-0.11788935,0.02764269,-0.005543272,0.00209341,0.090399146,0.0072984267,-0.0013539612,0.070460156,-0.00015742521,0.012354422,-0.008585516,-0.031305004,-0.052631173,-0.044910792,-0.016192164,-0.006185522,0.062895045,-0.009381217,-0.06311833,-0.05477293,0.0020476817,0.05969781,-0.036092866,-0.0028751355,0.029788945,-0.10768882,0.09865602,0.05341241,-0.058115512,0.073943354,0.022072246,0.037653856,-0.03774266,-0.05692843,0.039686278,0.05126582,-0.05329087,0.04469568,0.030450735,0.06539334,0.043114442,-0.09506392,0.028241012,0.012031604,-0.019424973,-0.032023065,0.04786433,0.033469357,0.004243315,0.014982596,0.02936609,-0.007362931,-0.05600432,0.0050085234,0.0125459405,-0.05664157,0.015303819,0.008137672,-0.046284076,0.020008022,0.02247087,0.09809639,-0.07457358 +2.1.1.361,"The enzyme catalyses the monomethylation of the L-lysine20 residue of histone H4 (H4K20). This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase. This enzyme plays a pivotal role in DNA replication. Activity is high during the G2 and M phases, but declines significantly during G1 and S phases. Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.",384,1.0,0.01913237,-0.0074215406,-0.02047203,-0.04576646,0.045071833,0.0492492,-0.0883554,0.0050695776,-0.039275154,0.0031557407,0.04679326,0.092327304,0.02536831,-0.023930406,-0.0151180765,0.09067455,-0.13736168,-0.025438864,-0.079516225,-0.09865578,0.046310034,-0.026433662,-0.037568204,-0.007379513,-0.00235708,-0.05422943,0.029472245,-0.020809522,0.04579646,-0.07095529,0.049539592,-0.043180503,-0.039363142,0.0143925445,0.072606154,0.03676394,0.049485292,-0.029788228,0.036573302,-0.033686746,0.04504759,-0.033344097,-0.073272064,0.038171317,-0.053731237,0.003170397,0.04757272,-0.025189348,-0.026444618,0.006881086,0.032077264,-0.06459768,0.03464294,-0.043463808,-0.06151416,0.017467493,-0.034467433,0.0069578867,0.08990108,0.054210138,0.05704605,-0.0014911047,-0.014381785,-0.024321252,0.104250945,-0.054239,0.12788406,-0.06707659,0.004673925,-0.0028932749,-0.0046413536,-0.08071014,0.022045188,0.04938939,0.013874682,-0.039414324,-0.058340386,-0.029562248,0.06461191,0.028648814,-0.045697168,-0.08208619,0.09529065,0.01043481,-0.0025609396,-0.049115166,-0.007732181,0.03792753,0.08631481,0.0015586781,-0.040368013,-0.014214424,0.014383391,-0.003282979,-0.0678054,0.1040562,0.026575245,0.032544103,0.031375073,-0.032055564,0.012957137,0.027611535,-0.089977704,0.0045694634,0.041536804,0.029311636,0.03974435,0.02728505,-0.024895933,-0.040636852,0.06389724,0.082502596,0.033512656,0.07343726,0.018534452,0.06324965,0.017410101,-0.034785524,-0.022979142,-0.014852922,0.039511036,0.007216546,0.08547049,0.029977946,-0.103948265,-0.0011593666,-0.050044388,1.5435189e-33,0.06814645,0.046491396,-0.0027478223,0.025049854,0.029119562,-0.016401697,-0.05813086,0.02155344,-0.023335302,-0.05428925,0.045607813,-0.0926377,0.06162537,0.032098997,-0.13100472,-0.029935818,0.022447713,-0.02817158,-0.018491028,-0.014504228,-0.0741455,-0.07398144,0.0072392263,0.062351733,0.0020723157,0.073777385,0.024391891,0.0073986975,0.100377165,0.032263547,-0.08773335,-0.088727094,-0.0147946775,0.053062752,0.018089833,0.036239963,-0.0335683,0.024008187,0.022301786,0.044101946,-0.018631225,0.0032419849,0.01151819,-0.10870945,0.047812663,-0.02846747,0.00070824777,0.0490567,-0.052742444,0.018085223,0.009010024,-0.04923027,0.039105378,-0.04902047,-0.002960378,0.0036222877,0.0031967228,-0.08405386,0.009337952,0.0056437845,0.025043957,0.023371447,-0.014422471,0.096007414,0.06989427,0.004066815,-0.028323686,-0.05878296,-0.020922156,0.07123994,0.01163904,-0.04889913,0.12226249,0.017911796,0.05772791,-0.03868052,-0.057364356,0.0025333902,-0.015467064,0.09578111,-0.011266357,0.0046017687,-0.07734904,-0.08753386,-0.061153013,-0.064931996,0.027860891,-0.09587393,0.008757735,0.056446675,0.011379677,-0.09023659,0.09017429,0.0024744489,0.029913547,-3.3929238e-33,0.026544182,-0.0396576,0.06741153,-0.02621761,0.010978076,-0.009746761,0.09242271,0.06382689,0.024418041,-0.017463489,0.10152928,-0.00055024656,-0.029058447,-0.0141227115,-0.0042862683,-0.010497362,0.025902713,0.06873121,0.042528808,0.0060486477,0.014101038,0.08238971,0.010562007,0.12502229,0.077347405,-0.028561449,-0.0623441,0.059821855,0.10547119,0.039487,-0.030099263,0.028929355,0.03971509,-0.0007132238,0.05015972,0.057650153,-0.008492664,-0.0268493,0.022446726,-0.04668815,-0.027965542,-0.022716422,-0.011712738,0.029045666,0.010053649,0.08790213,-0.039569695,0.078184515,-0.011474685,-0.089920506,0.025832444,-0.007516177,-0.062363416,0.025052303,0.02074142,0.016189612,0.008572149,0.03488939,-0.107271194,0.052811544,-0.08377279,-0.05495254,-0.021012742,0.07458219,-0.013110654,0.023588477,-0.071431026,0.026676899,0.026265193,0.06280654,0.048996728,0.0044307285,0.006290605,0.007392965,-0.055685215,-0.012736142,-0.07205702,-0.094622456,-0.032571927,-0.09025792,-0.02206418,-0.04030251,-0.035617765,-0.047002256,-0.0070204325,-0.12545528,-0.04620878,0.12446985,-0.008441429,-0.0021464876,-0.036605306,-0.049436573,-0.14234594,0.029049482,0.033194304,-4.3189953e-08,0.0012884769,-0.051777795,0.047317516,-0.04211379,-0.005868937,0.062019218,-0.0286503,-0.022192102,0.10297463,-0.0005605927,-0.033459112,0.024322663,-0.013760679,-0.051157225,-0.08732634,-0.011916313,-0.043063726,0.07481162,-0.009500633,0.01412895,-0.04585316,0.016831743,-0.015046824,-0.05415862,-0.041341912,0.011411223,0.033387806,0.106853105,0.021834262,-0.1342752,0.07472505,-0.003749416,0.018303618,0.032751095,-0.120575115,0.0042743487,0.013681694,-0.016835677,0.06774699,0.0023796223,0.059569664,0.010943361,-0.07505175,0.027367283,-0.02349911,-0.030383881,-0.013483073,-0.026735725,-0.027886773,-0.03362131,-0.03977402,0.00078648113,1.4565175e-05,-0.04017263,-0.01823847,0.041387938,-0.021747967,0.0075964546,0.024469843,-0.09407402,0.048192166,0.014856789,0.06289651,-0.09265053 +2.1.1.362,"This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine20 of histone H4 (H4K20m1, generated by EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine20 in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated.",384,0.99999994,0.042766556,0.028646493,-0.06942728,-0.054490052,0.056744486,0.05994381,-0.06796747,0.0026913742,-0.060623746,-0.033806663,0.013720071,-0.008520544,-0.016486865,-0.0029477216,0.0025885412,0.07834344,-0.15113975,-0.028139412,-0.10813431,-0.12077933,0.04736471,0.03420274,-0.02234003,-0.04263864,-0.0015043808,-0.06390546,0.03543395,-0.011579199,0.07099796,-0.0529785,0.04954168,-0.023856115,0.045972362,-0.054973137,0.05972809,0.042883456,-0.0020864236,-0.03771289,0.07543798,-0.00108795,0.075389974,-0.012205081,-0.04894922,-0.006039717,-0.06671278,0.013936782,0.061432905,-0.044586092,-0.023461923,-0.02389514,-0.0019257396,-0.028167197,-0.003380272,-0.029430285,-0.0657629,-0.012710297,-0.048240148,-0.016060678,0.05550548,-0.031355765,0.0388881,-0.028339716,0.0035940239,-0.031523604,0.032098997,-0.052019898,0.09828907,-0.057711147,0.036132768,-0.04779081,-0.00827404,-0.054726243,-0.02433229,0.06019008,-0.0018526143,-0.040580317,0.008363873,-0.004879915,0.04090923,-0.012962666,-0.031094236,-0.011006522,0.07853142,0.0040672747,0.008619411,0.0009006894,-0.0546854,0.046312563,0.0638427,0.024527693,-0.03071313,-0.061188713,-0.033176113,-0.0076855537,-0.033598203,0.09701349,0.059305087,0.03592622,0.025940152,0.011553464,0.03807549,0.03313117,-0.10694424,0.0457487,0.03600148,0.06390143,0.051492974,0.092327215,-0.02969193,-0.02351364,0.044934966,0.037769593,0.031275555,0.041715555,-0.0072492864,0.05984049,-0.0101725785,-0.0146228755,0.0043034395,0.005472668,0.011048734,0.036148373,0.09649317,0.036654156,-0.060830392,0.014472034,-0.14526403,5.4645265e-33,0.029390857,0.12203472,0.010170432,-0.0072460007,-0.017922714,-0.047196724,-0.0951522,0.065026045,-0.0038191914,-0.067734204,0.015523926,-0.04404854,0.06267727,0.036964063,-0.11379648,-0.07730531,-0.0054358495,0.015861021,-0.0017145778,-0.043923788,-0.0744695,0.036823936,-0.021967156,0.035521116,0.00019720967,-0.004214421,0.03692204,7.533577e-05,0.09047259,0.026888855,-0.09248192,-0.0709403,0.035754565,0.012296243,0.05897655,0.06808565,-0.029399019,0.034557503,0.031957474,0.10199758,0.040114805,0.020088675,-0.015278216,-0.09044458,-0.0068252655,-0.04009091,-0.048553236,0.038305786,-0.062321194,0.03941542,-0.006548005,-0.027635219,0.08445161,-0.06778786,-0.065431595,-0.030119779,-0.018869728,-0.07538976,0.021786021,0.0337567,-0.017428998,0.021619162,-0.009216466,0.059785802,0.054849815,-0.03744712,-0.025582524,-0.05062785,-0.018250637,-0.0126198605,-0.018492792,0.002456583,0.14958997,-0.009178607,0.052145533,-0.07315786,-0.04645176,-0.020408712,-0.01751382,0.05363892,0.029448558,0.05113291,-0.061769,-0.059403874,-0.02697615,-0.05815411,0.03207342,-0.11521268,0.004618759,0.046008185,-0.042089663,-0.1202422,0.049839675,-0.018448072,-0.02236505,-7.006808e-33,0.018960671,0.0015836842,0.039191313,-0.02377562,-2.271686e-05,0.007745015,0.09248459,0.022165192,-0.01701943,-0.02409633,0.09672431,-0.0046465625,0.010631623,-0.07875597,-0.019963844,0.041623518,0.031983174,0.08629323,0.011265094,0.008645544,0.007453544,0.04347721,-0.024504183,0.1413977,0.05461722,0.03071766,-0.055141713,0.052725777,0.097559325,0.06178959,-0.077563524,-0.03493665,0.0067135636,-0.038431887,0.008023751,0.03482403,-0.027338946,0.010301671,-0.006643494,-0.018365191,-0.018498354,-0.00198654,-0.006634138,0.089663915,-0.005074986,0.11878772,-0.072159655,0.08353508,-0.028430026,-0.087197304,0.034581028,0.02701788,-0.054850593,0.07430673,0.012436601,0.027174246,0.041324873,0.071118236,-0.074209906,0.020273384,-0.07078628,-0.0446504,0.0049633314,0.046428546,0.035654288,0.02649298,-0.07157357,0.007273542,-0.011325159,0.043389168,0.040580142,-0.0048881415,0.023606608,-0.0066352417,-0.021944668,0.009332984,-0.053447556,-0.13736793,-0.107882634,-0.058309104,0.0088920165,-0.061549425,0.017568184,-0.07788018,-0.017645132,-0.117147885,-0.00901384,0.11110063,-0.019336563,0.0032867661,0.00033287465,-0.0055264262,-0.10815202,0.067461714,0.057594523,-4.618374e-08,0.023047276,-0.09027344,0.02535744,-0.031945232,-0.040568132,0.08528796,-0.036961604,-0.008052816,0.09580501,-0.032682482,-0.015462549,-0.002970603,-0.054794945,-0.05404842,-0.044657692,-0.009651383,-0.07669962,0.08042238,-0.0309877,-0.0384111,-0.056107607,0.05325105,-0.015766023,-0.060289998,0.009989074,-0.010411505,-0.008948611,0.07567096,0.03285332,-0.093690954,0.067868896,0.040192243,0.0041884463,-0.016475974,-0.06449468,0.012836817,0.036506798,-0.022189653,0.0236311,0.015536133,0.034788642,0.0005984773,-0.107430294,0.05220739,0.01949041,-0.0536326,-0.02564269,0.040186718,-0.0006402988,-0.041398503,-0.012426505,0.01239801,0.009160103,-0.048290845,-0.035095602,0.06399694,-0.077943414,-0.011734252,0.0076903584,-0.03205151,0.027133623,0.04534609,0.08652888,-0.053220738 +2.3.1.288,"This mycobacterial enzyme catalyses the acylation of 2-O-sulfo-alpha,alpha-trehalose at the 2' position by a C16 or C18 fatty acyl group during the biosynthesis of mycobacterial sulfolipids.",384,1.0,-0.0593569,-0.060519584,-0.14098981,0.0011608897,-0.07253682,-0.01625636,0.012711215,0.031860024,0.0030958045,-0.0039774734,0.016842052,-0.057273574,-0.04969139,-0.006902306,-0.042280015,0.073413976,-0.026137123,0.0038596292,0.011764952,-0.081443466,0.039351504,0.03897996,-0.0055713174,-0.051523484,0.040813845,0.03338322,-0.007842635,0.0061659683,-0.042880543,-0.06624378,0.022209706,-0.05997535,0.07284159,-0.028886613,0.104568586,0.040563814,-0.0141638275,-0.08970979,0.102905475,0.02602844,0.027793312,-0.004652366,-0.016203335,0.008673675,0.005979546,-0.020202432,-0.034474146,0.08453849,0.0022717048,-0.05299203,-0.07278817,-0.0076544425,-0.0750279,0.025995646,0.03988516,0.08503678,0.00850199,-0.035871454,-0.02777865,0.018981814,0.038263902,-0.021563131,-0.004443245,0.069206335,-0.053506516,-0.09153594,0.01868324,-0.06302536,0.02712965,0.006959458,-0.13283934,-0.034130268,-0.011802161,0.04348499,0.0048228195,-0.026576314,0.017425103,-0.07852933,0.08167551,0.005531541,0.040587384,-0.013264109,-0.0037332317,0.027929429,0.028772786,-0.12294669,0.123292826,-0.016339872,0.08889483,0.11898699,0.06338384,-0.06983861,0.040940523,-0.038452137,-0.07816785,0.014572889,0.08283177,0.016104732,0.0047185053,-0.028084774,0.016191475,-0.066609055,0.028036898,-0.09900182,-0.06053279,0.020164708,-0.02983671,0.10257781,0.041127447,0.0752207,-0.048087705,-0.0074329595,0.00862083,-0.017537333,-0.0117213335,0.13444044,0.039416514,-0.030541657,-0.053395186,0.00037325174,-0.0069755907,-0.020334657,-0.017382465,0.046694323,-0.074855186,0.053457405,-0.10320478,1.4855325e-33,0.063544504,0.1033924,-0.007054642,-0.056495965,-0.009991904,-0.08475447,-0.16958126,0.022028832,-0.057819545,0.012083801,-0.011188889,-0.07610779,0.014814844,0.06457947,-0.049408257,-0.005237937,0.023875194,0.05116773,0.03938537,0.004374252,-0.059386954,0.034853958,0.025717083,-0.054256342,0.015813084,0.015768088,-0.03966806,-0.0026640925,0.008021297,0.02836314,0.08869644,-0.07993351,-0.041733306,-0.030091014,0.089484826,-0.04152636,-0.032714516,-0.06234207,0.027444381,0.06617158,0.009866207,-0.0069828504,0.05293227,-0.039057318,0.06189423,-0.08712937,-0.09198695,0.065095104,0.029791063,0.06287945,0.016668355,-0.04422417,0.05694335,0.05234957,-0.005953511,-0.027068764,-0.052088454,0.004067528,0.04931712,-0.041299686,0.016626773,0.045835055,-0.055603568,-0.034160476,-0.09956461,-0.047579225,-0.019042136,0.028695762,-0.028227104,0.055554602,-0.03574686,-0.037716962,0.008062496,-0.025868118,0.07776384,-0.026941057,0.009176174,0.02173139,0.0064165355,-0.027692461,-0.010280636,0.0017803141,0.0058051953,-0.020631062,-0.030702148,-0.054194394,-0.07514759,0.04695077,-0.026834134,-0.0007823756,-0.07143235,-0.035603303,-0.04803854,0.07791359,0.040313672,-4.284233e-33,0.07832208,-0.14129724,0.07783519,-0.14665924,-0.05581977,-0.024772516,0.033348713,-0.01348138,0.029689858,0.014333328,0.015439726,0.016312603,0.04221562,-0.064916916,0.03632855,-0.026324801,0.031587124,0.055569135,-0.028717821,-0.042078286,0.030423092,0.03464002,0.0039280024,0.0018573083,0.010062677,0.016687484,0.028151574,0.02674838,0.061140083,0.11127744,0.02235661,-0.077881776,0.013116954,-0.056829385,-0.053206053,0.024490656,-0.059667934,-0.021957025,-0.00093829556,0.039633933,0.010480846,0.017677445,0.05598081,0.027622456,0.033745684,-0.039590813,-0.062915824,-0.018230325,-0.030289615,-0.07625657,-0.0028160957,0.036215708,0.03155715,0.017520228,0.0012526014,0.06188896,0.016303107,-0.051319357,0.0057176575,-0.09623726,-0.06126407,-0.006245629,0.0340663,-0.044750456,0.06601274,0.06273143,-0.033399552,0.0075585265,0.02265607,-0.061041057,0.0067602624,0.030071853,-0.096921556,0.0097654965,0.00078221905,-0.04905038,-0.04167691,0.02824611,0.015839284,0.033517797,-0.039653804,0.005419178,0.06734381,-0.059371978,-0.05143483,-0.08395486,0.019751867,0.0934106,-0.030372998,0.053619616,-0.015745798,0.043880243,-0.00034533863,0.03687152,0.03475224,-3.157928e-08,0.016693851,-0.041948833,0.084789746,0.03495297,0.03567897,0.093929715,-0.07266318,-0.034596447,0.06327871,-0.052739564,-0.020208905,0.11550499,0.08129683,0.0147639355,0.036623944,0.03521958,-0.068603106,-0.0951025,0.0011506503,-0.057250533,-0.040953353,-0.008144544,-0.024549654,0.0586581,0.03851562,-0.043637205,0.0032502052,0.022788767,-0.056512106,0.028590642,0.026178448,0.054307297,-0.027444264,-0.017576728,-0.0029258344,0.0049724593,-0.04050553,-0.11725422,-0.0056066886,0.014919078,0.070157684,0.0044358466,-0.024660002,0.069243714,0.010498323,0.05285202,0.039403778,0.009793144,-0.048148327,0.057163153,0.043123662,0.016664177,-0.08049007,-0.0031135178,-0.032257486,0.01713715,0.027328184,-0.015890298,-0.016969847,0.024368584,0.06786349,0.020201618,0.12134904,-0.053069197 +2.3.1.289,"This polyketide synthase, characterized from the bacterium Streptomyces thioluteus, generates the backbone of the antibiotic aureothin. It is composed of 4 modules that total 18 domains and is encoded by three genes. The enzyme accepts the unusual starter unit 4-nitrobenzoyl-CoA and extends it by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalysed by only four modules. The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric).",384,1.0,-0.05407985,-0.018896192,-0.07473676,-0.03963029,0.051908243,0.0061173216,-0.053307135,0.016154232,0.10094621,-0.06866044,-0.017023657,-0.085532814,-0.015375124,-0.0032643098,-0.12179366,0.034325477,-0.08806818,0.01763314,0.008246993,0.0009853579,0.07200403,0.032074917,-0.017421236,0.009790342,0.0055383625,0.06256868,0.07147803,-0.07095344,0.031833928,-0.06641661,0.04553045,-0.021023875,0.027614713,-0.025606005,0.066417955,0.095760435,-0.04262124,-0.013396985,0.07130904,-0.011447481,0.0953644,-0.021871574,0.016131654,-0.0043886537,-0.019881787,0.024566025,-0.038977206,1.5870988e-05,0.05673848,-0.026563011,-0.027875999,-0.046615057,-0.04746455,0.07622298,0.043233454,0.006745537,-0.0935199,-0.002078955,0.042379662,-0.05305932,0.08823708,0.004464462,0.015808394,-0.011700343,-0.0022208116,-0.04067215,-0.012200152,-0.038613904,-0.015128031,0.030342998,-0.09053601,0.047931686,-0.036161717,0.055963017,0.08859228,0.05860638,-0.0032914153,-0.027778147,-0.022668337,-0.019064175,0.0300731,0.07031783,0.09090789,0.096516855,0.008247087,0.023008738,0.097524576,0.020536099,0.039473306,0.0119431,0.010773057,-0.02756919,-0.00039289764,-0.038622107,-0.056833155,0.038170714,-0.005650114,0.03261875,0.07122879,0.0067550745,-0.04185049,0.018744947,0.014644367,-0.0648792,-0.06177975,-0.029490147,-0.03284456,0.111225516,0.07921684,-0.040516283,-0.036344033,0.013330471,0.058758046,-0.022220625,0.03891701,0.03433313,-0.0054553915,-0.019252332,0.032725666,-0.0060817497,0.022831568,-0.016697077,0.034180593,0.0426842,-0.032714453,0.016950365,-0.11217254,3.394408e-33,0.04566783,0.051056642,0.08626738,-0.012593628,0.012665584,-0.059046037,-0.08994977,-0.009210147,-0.099956244,0.009851962,-0.050200656,-0.086862765,-0.009865555,0.072444364,0.043316696,-0.074437,0.0002742977,0.02263287,0.03102846,-0.032308627,0.0047152815,0.09653648,-0.061412133,0.027742026,-0.0012198292,0.073438294,0.062799364,0.064578176,0.05916664,-0.025265243,-0.03492711,0.026935859,-0.077683695,0.021777166,0.039170872,0.024827532,0.02212714,-0.01907394,0.032563955,0.055483617,-0.02743434,0.0014145041,-0.029927082,-0.090296715,0.08753405,-0.060185347,-0.059298664,0.04083401,0.0038915016,0.07368395,-0.020237245,0.0082764905,0.051348742,0.023633458,-0.06033808,0.03345776,-0.04917974,-0.009968735,0.048127934,0.009923835,0.012641293,-0.010861214,-0.040331125,-0.00010193293,8.6803375e-05,0.046003114,-0.025066527,-0.059368413,0.040046815,0.065734185,-0.057978295,0.0346879,-0.029725885,0.020189378,0.061567426,-0.027656948,-0.08621617,-0.018140197,0.041811816,0.04172414,-0.061063226,0.05445036,-0.023942154,-0.07349272,-0.025495913,-0.03706434,-0.05537563,-0.010456633,-0.057255503,0.046374906,-0.00021810924,-0.14463685,-0.008202315,0.033684414,-0.08308691,-4.1061443e-33,0.15032266,-0.115353785,0.022871155,-0.046241086,-0.081866756,0.04789394,-0.021693854,0.004292883,-0.038993437,-0.05857275,0.12250071,0.009192023,-0.0018609012,0.0626948,0.027277142,0.033944804,0.0077380645,0.015502764,-0.01847896,-0.02721491,-0.0020548352,0.058821995,-0.051691238,0.055714503,0.030860936,0.05174448,0.0035771972,0.12363635,0.026115023,0.09042404,-0.03433126,-0.056197442,-0.033427384,0.018329427,-0.08755764,0.054569732,-0.047942758,0.02794924,0.032416567,0.022495165,0.027356273,-0.034395702,-0.0056026396,0.03832043,0.043091048,0.08619781,-0.083682165,0.042504095,0.04834041,-0.09552598,-0.00080457487,0.026966907,-0.0017615558,-0.008531423,-0.051351447,0.032201182,0.030323211,-0.020722127,0.036124412,-0.09426853,-0.05971901,-0.06285525,0.080262564,-0.021923492,-0.0029728333,0.07609703,-0.048277576,0.061167683,0.023965301,-0.04661786,0.031330265,-0.011607409,0.0131707415,0.03423375,0.008939631,-0.060668077,-0.03290183,-0.03338938,-0.021556657,-0.027222129,-0.057892404,-0.064769715,-0.008464106,-0.059677508,-0.060144205,-0.041356698,0.10306462,0.019492427,-0.005481114,0.059315458,-0.02996998,0.1059403,0.027545225,0.09725178,0.06350071,-4.7446154e-08,0.025126906,-0.07952909,-0.0046722954,-0.020024968,-0.0146966325,0.019517085,-0.028121578,-0.037515067,-0.032315228,-0.075298704,-0.059649397,0.052245744,-0.021584775,0.057663772,0.0086501995,0.009792042,-0.014800916,-0.006807618,0.0005744233,-0.12765034,-0.11123969,0.031520307,-0.078339495,0.014655727,0.025101291,-0.068331756,0.07528106,-0.001298622,-0.022891745,0.0280474,-0.019556087,0.08673855,-0.046870474,0.01476973,-0.017779851,0.047076248,-0.08685809,-0.074540906,0.012471596,-0.014072801,0.06614473,0.05245591,-0.0710108,-0.026577096,-0.025076328,0.004548411,0.02974615,-0.044418875,-0.059681855,-0.044019993,0.0471347,0.021203838,-0.022881199,0.009199523,-0.056554265,0.07285865,-0.021303827,-0.06598327,-0.052555818,-0.014850072,-0.057218324,-0.048016537,0.16207501,-0.017376304 +2.3.1.290,"This polyketide synthase, characterized from the bacteria Streptomyces orinoci and Streptomyces spectabilis, generates the backbone of the antibiotic spectinabilin. It is composed of 6 modules that total 28 domains and is encoded by four genes. The enzyme accepts the unusual starter unit 4-nitrobenzoyl-CoA and extends it by 6 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by norA) is used twice in an iterative fashion, so that the seven Claisen condensation reactions are catalysed by only six modules. The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric).",384,0.9999999,-0.03392841,-0.036012262,-0.08628162,-0.05209077,0.046818838,0.018247504,-0.039831698,0.043007985,0.083128355,-0.056873977,-0.0056796097,-0.062166315,-0.017574338,0.038271785,-0.13795617,0.03037044,-0.10844365,-0.008776709,0.014102764,0.013630343,0.09326347,0.025049735,-0.00197591,-0.012710793,-0.007457886,0.059996884,0.0899063,-0.057686366,0.035494972,-0.07713586,0.059683744,0.0058913757,-2.531995e-05,-0.019987592,0.098983824,0.08874958,-0.0112099955,-0.025961831,0.090002604,0.04948735,0.08603726,-0.046959806,-0.02239109,-0.0189467,-0.004031095,0.001805669,-0.019354729,0.01147022,0.060762115,-0.0584814,-0.06294198,-0.05437319,-0.05806707,0.087274015,0.077560745,0.014222675,-0.08460729,-0.022226797,0.026513526,-0.04201942,0.05331142,0.01833184,0.03738988,-0.015836574,-0.008603986,-0.026287682,0.014588026,-0.048370253,0.0143830795,0.00075851975,-0.12331074,0.05095251,0.0037469633,0.06259011,0.037660595,0.045286316,0.02321706,-0.043181546,-0.04608717,-0.052234165,0.043035056,0.06050375,0.07358406,0.08943147,0.026004829,0.02072587,0.091021046,0.03043416,0.03672068,0.016106818,0.004649778,-0.03827406,0.0038819052,-0.03734517,-0.07421774,0.027928606,-0.037071854,0.002146348,0.063264705,0.0012339618,-0.04237304,0.0035995764,-0.0017107698,-0.07736461,-0.08996912,-0.011320195,0.025898343,0.1115852,0.057924807,-0.008725213,-0.02804752,0.029881343,0.014761139,-0.029101282,-0.0033748094,0.04099129,0.0031367142,0.012018729,0.03494788,0.017487688,0.030340051,0.023379,0.043413114,0.060984556,-0.057914056,0.04713699,-0.09543939,4.25604e-33,0.05429367,0.05476377,0.06243853,-0.015176217,-0.00021669084,-0.060759284,-0.08122486,-0.013225927,-0.10614833,-0.015802383,-0.059220225,-0.10127296,-0.013723013,0.06192328,0.08532172,-0.05983705,0.004266396,0.0063579185,0.0077584754,-0.025902089,0.014293309,0.0923782,-0.049508773,0.015619643,0.034053683,0.07347088,0.028817363,0.06027789,0.0481532,-0.033119086,-0.02381787,0.017106209,-0.06275754,0.066252775,0.06240595,-0.0033091241,0.044454228,-0.031044487,0.07234714,0.05512813,-0.054147165,-0.010140017,-0.021751229,-0.06827054,0.09498572,-0.044886466,-0.06197448,0.06565491,0.021332974,0.06055832,-0.009438919,-0.002034745,0.035365473,0.01425999,-0.07377362,0.024442049,-0.061154258,-0.013970515,0.061147075,-0.007536975,0.024396492,-0.009260448,-0.04340389,-0.013002424,0.023700383,0.041428085,-0.046760187,-0.01807382,0.026013987,0.033910852,-0.09908066,0.025893528,-0.011913722,0.022964202,0.05510744,-0.020990074,-0.10069456,-0.003891573,0.034284152,0.03515875,-0.024166293,0.042477496,0.0018725281,-0.07363957,-0.034576178,0.0044215517,-0.050966505,0.015388877,-0.052085564,0.024467371,0.006869731,-0.10966465,-0.015061396,0.0005035166,-0.04749453,-4.9343095e-33,0.153505,-0.10094554,0.027212331,-0.048370875,-0.11092948,0.030393118,-0.015447706,-0.030572746,-0.062884904,-0.05769604,0.080422655,0.008668673,-0.006801278,-0.0014127187,-0.0046983804,0.024829827,-0.030951185,0.038620576,-0.022014342,-0.048064232,-0.0059265057,0.050540753,-0.05311939,0.031164244,0.046693318,0.06207318,0.017387705,0.103182174,0.030116191,0.07965021,-0.038041342,-0.069504716,-0.04437959,-0.009789105,-0.057991266,0.0733012,-0.0935841,0.009445703,0.032211274,0.023283225,-0.00033993492,-0.036147863,0.021630542,0.008772478,0.022487298,0.057451837,-0.055866536,0.0024493283,0.0563776,-0.124193005,-0.010192535,0.049095824,-0.0029867126,-0.027667003,-0.05324187,0.021364342,0.04359373,-0.025633238,0.06521129,-0.11205347,-0.02572959,-0.06080042,0.07618082,-0.0058086216,0.027236864,0.06728172,-0.03232189,0.04292941,0.06264025,-0.06700109,0.04897794,-0.025546126,0.0036445777,0.033188317,-0.010939262,-0.05275315,-0.06575131,-0.026221886,-0.04397575,-0.008429275,-0.022788612,-0.07978166,-0.040891603,-0.05812494,-0.03397702,-0.016180713,0.11644672,0.022060512,-0.0024592248,0.027966375,0.012399045,0.08883712,0.03496437,0.0776658,0.04987001,-4.7910575e-08,0.045721147,-0.09698558,-0.0106924325,-0.019895846,0.016451282,-0.005000937,-0.037070397,-0.05445485,-0.0051658917,-0.09111075,-0.048480213,0.051070884,0.005657,0.07107757,0.025637185,-0.022671254,-0.021136766,0.014566178,0.009388542,-0.10098807,-0.12716413,0.0053307526,-0.11955023,0.049086217,0.025547385,-0.04288728,0.07380672,0.036428105,0.011598618,0.043274716,0.0048091817,0.06076661,-0.018453322,0.009784999,-0.0061979447,0.0546168,-0.08910856,-0.02346378,0.0074327183,0.0032544595,0.07154174,0.02818797,-0.04248953,-0.0061259535,-0.011377128,-0.0052001756,0.020878002,-0.031519767,-0.04350217,-0.010667186,0.046430055,0.02652748,-0.03447246,0.0278041,-0.08869316,0.06714773,-0.027288698,-0.07615593,-0.0503285,-0.034242146,-0.048496403,-0.043775693,0.15822805,-0.021761639 +2.3.1.291,"Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.",384,1.0,-0.10370776,-0.11579252,-0.060180895,-0.06268147,0.061545353,-0.0052181114,-0.118767254,0.05961129,0.037814364,-0.010876581,0.097504295,-0.12917481,-0.086238354,0.08161839,-0.030654222,0.014695216,-0.09096888,0.038581256,0.045583263,-0.09901696,-0.0055098804,0.06016909,-0.010928111,0.009525692,-0.026964955,-0.09629396,0.00408041,-0.04641744,0.026104784,-0.076101266,0.047392648,0.034097437,0.0021489777,-0.061411403,0.021993846,-0.008860694,-0.029081233,-0.019920642,0.08244794,-0.0030923798,0.09157758,-0.032618485,0.050136063,-0.02937928,-0.03644419,-0.022640076,-0.068687804,0.054594886,0.018817522,0.019935546,0.011233686,-0.069395944,-0.1129285,0.028822051,-0.11095597,0.0065382714,-0.071126044,-0.0023254452,0.031507798,0.020834738,0.006524198,0.029798167,-0.023374168,0.00045405515,0.012549539,0.006373323,0.04099549,-0.0670801,-0.046845634,0.051674567,-0.043235347,-0.107644044,0.07722592,0.13184595,-0.0074899187,0.049040534,-0.014793972,-0.030141402,0.024897896,-0.08365138,-0.06270641,0.030804222,0.014531722,0.03166454,0.060758054,0.03088873,0.007978283,0.04252472,-0.005246395,-0.039302938,0.10452961,-0.055866797,-0.08475604,-0.037538588,-0.102997094,0.09017756,0.00214954,0.050078176,0.035106424,-0.07563836,0.012873974,0.007981176,0.039496318,-0.082318224,-0.0013028078,0.00599553,-0.023110028,0.036007755,-0.02782737,-0.013527034,0.0046645612,0.047596686,0.031789053,-0.030550376,0.08638597,-0.009060647,-0.099173516,-0.061155777,0.013442587,-0.0007709966,-0.02207015,0.027562387,-0.0057722395,0.049999867,-0.04137172,-0.006442592,-0.015273176,5.2913126e-33,0.046422716,0.04395805,0.08642877,0.041919645,-0.016168064,-0.0019133395,-0.052732293,0.044758707,-0.109323144,0.014950297,-0.007998813,-0.041686416,0.03240656,-0.0016960048,0.03395378,-0.023174653,0.0107143745,0.019196218,0.055327665,-0.06557122,-0.008537361,0.05963122,-0.010811838,-0.0043600425,0.08694194,0.06535823,-0.0711675,0.032329246,-0.01038387,-0.014879369,-0.103529796,0.025003122,-0.03200922,0.040460404,-0.002986258,-0.01360956,0.063849494,-0.0820989,-0.008090594,0.069214076,0.092924304,0.021821521,0.016819622,0.013128297,0.06453828,0.0062158247,-0.102280624,-0.041936465,-0.040671494,0.0055446634,0.027734242,-0.0022473407,0.069072686,0.017407339,-0.001977863,-0.005369645,-0.05337758,-0.04748269,-0.010136577,0.008481694,0.011734886,0.06614693,-0.08543805,0.004839126,0.0023555907,0.024436677,-0.05725006,-0.07077621,-0.05627805,0.018690255,-0.028471703,-0.045419913,0.073215835,0.078632884,0.019767601,0.0061688256,-0.012780858,0.063754395,-0.028303603,0.034415476,-0.036254205,0.03210839,-0.043434795,0.023853257,0.022899218,0.014596475,-0.01437054,-0.0044753235,0.040977128,-0.008124797,0.077976055,-0.108111575,0.010317803,0.017848497,-0.034100346,-4.9516495e-33,0.037877638,-0.051255085,0.059012495,-0.07812773,-0.04597856,0.02636404,0.0125464415,0.0034769704,0.06313822,-0.021911724,0.042335708,0.02219944,0.04204391,-0.121316254,-0.019877873,0.056728236,0.022733899,0.044141624,0.01369861,-0.058757786,0.08108401,0.045701426,-0.03552322,0.07402204,0.052602828,0.08515759,-0.050988663,0.038358524,0.054734103,0.03940519,-0.046714254,-0.021157792,0.042813763,-0.028379418,0.020571122,-0.08520873,-0.01089496,0.110511824,0.0010277595,0.048163936,-0.056300785,0.100797296,0.018705798,0.095752016,0.0787254,0.05080756,0.012427491,-0.0052675074,-0.028801214,-0.011589673,-0.0030190628,-0.010378602,-0.046275344,-0.06376978,0.012843992,0.00212498,0.035889942,-0.026923802,0.06912133,-0.08083468,-0.04752195,-0.017741626,-0.0032187304,-0.03850691,0.07277645,0.07457991,-0.036592696,0.0731331,-0.015069026,-0.028978935,0.022760196,0.00092516764,-0.0058686435,-0.024947062,-0.035810374,0.0053957943,-0.0037027232,-0.09363246,0.018996233,0.016736878,-0.051455405,-0.050219696,0.058903717,-0.013559361,0.00045865384,0.05413529,0.0008150541,0.018258153,0.11827177,0.011366422,-0.032296874,0.01972884,0.040944237,0.034258276,0.06412627,-3.6575685e-08,0.058029987,-3.739634e-05,-0.011478952,-0.08958381,-0.013013526,0.023746107,-0.021705702,-0.010126086,0.09331182,-0.0017856105,-0.064176224,0.03973775,0.028802799,0.08734417,0.016726468,0.04028289,-0.0048615783,-0.03448351,-0.004228596,-0.05054279,-0.02820978,0.02109589,0.0077035483,0.051144443,-0.027696101,-0.023009358,0.015735067,0.06353295,-0.0073852926,0.008834463,-0.039491367,0.0370628,-0.006149255,0.06982819,0.108488925,0.019539896,0.012412232,-0.08252783,-0.02449217,0.10147195,-0.023336792,-0.10776508,-0.07836797,0.033087317,0.07509444,-0.015820237,0.02370479,-0.031252448,0.0021011059,-0.046464205,-0.06971039,-0.023995996,-0.032254398,-0.061378352,-0.090148665,-0.053452097,-0.04034527,-0.00022804836,0.010290315,-0.085510254,-0.023197291,0.0226676,0.16386361,-0.006691094 +2.4.1.369,"The enzyme, found in pathogenic strains of the bacteria Escherichia coli and Salmonella enterica, catalyses the transfer of glucosyl groups to C-5 of one, two, or three of the 2,3-hydroxybenzoyl units of the siderophore enterobactin, forming C-glucosylated derivatives known as salmochelins.",384,1.0,-0.068298526,-0.063101165,-0.10160811,0.01603703,0.031129051,0.03229341,-0.04625422,0.052640833,0.065210156,-0.038005754,0.03907505,-0.07610688,-0.063346855,0.042840898,-0.0629649,-0.029829219,-0.056397147,0.05163296,-0.07272405,-0.0519049,-0.025058948,0.0055455114,-0.008679339,-0.00057938555,-0.023524141,-0.047096495,0.08469991,0.00074752414,-0.06109858,-0.058153186,-0.04139969,-0.03194061,0.038478114,-0.03170612,0.07652275,0.08130314,-0.010819757,-0.11840355,0.08530145,-0.004887751,0.011440136,-0.029897932,0.026477605,0.046142798,-0.020969229,-0.081644095,-0.0008176704,0.053998556,0.1365815,-0.046773236,-0.04712365,-0.06664473,-0.06857444,0.05245595,0.005002931,-0.04273297,-0.08743249,-0.104915455,-0.01150886,0.011606063,-0.0037834723,-0.0054146666,0.05704279,-0.031588018,-0.09588776,-0.14722936,0.042421933,-0.07193748,-0.007198466,-0.01140568,-0.084353946,-0.05535838,-0.013643199,0.015887365,0.022532105,0.0071197124,0.030835152,0.063508615,0.052376036,-0.046926867,0.079555556,0.03621525,0.06938611,0.13535254,0.02318427,-0.010054628,0.024159627,0.032759838,0.07215945,-0.0031025377,0.01669017,-0.06270814,-0.019489558,-0.07974667,-0.087712206,-0.056133267,-0.02243398,-0.017169746,0.028253721,0.012690307,-0.027758962,0.03234561,0.06076017,-0.06675955,0.025020555,0.019797564,-0.0046511027,0.13720492,0.06814376,-0.077242404,-0.057677943,0.05487771,-0.00096291286,-0.013660521,-0.024019087,-0.005664454,0.025929568,-0.028104763,-0.020004774,0.051642947,-0.0045829215,-0.05212748,0.042433526,0.012265288,-0.10298211,0.020469064,-0.07319863,3.1774608e-33,0.040874008,-0.009151433,0.028822452,-0.0025318065,-0.05380456,-0.016606325,-0.08804379,0.018427633,-0.022523925,-0.049305137,-0.10078201,-0.065182425,0.015017971,0.06776789,0.034580164,-0.016013043,-0.07788653,-0.059689093,0.017226346,-0.03395678,-0.00065666786,0.05079152,0.0060071372,-0.07336643,0.067464046,0.06366603,-0.015853727,0.025381546,0.042870536,-0.011058659,0.011902214,-0.021079578,-0.07026131,0.039387908,0.0683039,0.044905435,0.025539927,-0.025864843,0.039630786,-0.006902382,-0.061768625,0.034067385,-0.045332827,-0.0699256,0.053455587,-0.04030418,-0.06285691,0.061960064,0.07689145,0.029817197,0.02803015,0.006384119,0.06850373,-0.026561974,-0.06453663,0.0193992,0.060466863,0.033781122,0.03529311,0.018321354,-0.019877702,0.070872396,-0.008692057,-0.0015623634,-0.019051744,0.051236425,-0.015666537,-0.016314637,0.017601738,0.046136424,-0.04224537,0.040012784,-0.0029864646,0.032473624,-0.041831315,-0.08619248,-0.04326521,0.03856392,0.097516574,-0.043112874,0.026633874,-0.018406482,0.025720999,0.08069418,-0.09665489,0.062024683,-0.08114558,-0.03086684,-0.030370075,0.052059703,0.034356263,-0.02054407,-0.071572825,0.0021657192,-0.012441922,-5.2370143e-33,0.090533786,-0.10776179,-0.009383305,-0.09916076,-0.048877057,0.036068995,-0.01983167,-0.008146628,-0.012125206,0.021236263,0.07891168,0.054037217,0.0030394702,-0.004082796,0.023418142,0.003933302,-0.02301208,0.0018825304,-0.059249416,-0.03759291,0.021299303,-0.012800951,0.061095055,-0.008814812,0.020088084,0.024199257,0.027136255,0.053426392,-0.0077729574,0.05220279,-0.04250918,0.00076796394,-0.005030947,-0.053592395,-0.016631912,-0.014158001,-0.013851451,0.04921746,0.00854989,-0.008719791,0.033084147,0.043251123,0.014538559,0.08095828,0.015049882,0.1170247,-0.047486406,-0.013258995,-0.037735224,-0.059254058,-0.004917256,-0.024941066,0.009816085,-0.06416054,-0.02235194,0.08814527,0.06320144,-0.14096974,-0.004512818,-0.0044880733,-0.06790969,-0.010568023,0.037811976,0.0032027508,0.058377255,0.043297973,0.004014266,0.017843654,0.05730541,-0.08044111,0.083017506,0.0019186467,0.066975065,0.011767528,-0.028216017,-0.0038095326,-0.049934387,-0.04485378,0.015652226,0.03676297,0.04234332,-0.06745202,0.0053789704,0.016485939,-0.019793628,-0.10286906,0.047025517,0.07826363,0.008684706,0.025457326,0.0055104126,0.08377814,0.0153687,0.057102896,0.079125665,-3.6983163e-08,0.03181116,-0.09462279,0.040218618,-0.033555795,-0.02401064,0.05312075,-0.08212498,-0.014495294,0.070668,0.015905809,-0.050474595,0.14009836,0.01060396,0.011093698,-0.10227844,0.08585839,-0.028524088,-0.04376065,0.027104216,-0.00041231874,-0.09167129,0.004930334,0.019825904,0.018419355,0.04291307,-0.09405937,-0.053210415,0.08686071,-0.031920828,-0.027048998,-0.030968525,0.05217035,0.03703703,0.033648994,-0.048936326,0.06737409,-0.05154959,-0.03873719,-0.010418602,0.025530346,0.044817176,0.028743982,-0.03168585,-0.00820537,0.018529756,0.048071973,-0.02036893,0.09224862,0.012936399,-0.05774053,0.026607351,-0.008990989,-0.032195747,0.018128427,-0.06499134,0.023207275,-0.016639816,-0.067698084,0.063302614,-0.036676966,-0.04827516,0.043567345,0.1226576,0.030105114 +2.4.1.370,"The simplest complex sphingolipid of yeast, inositol-phospho-alpha-hydroxyphytoceramide (IPC), is usually mannosylated to yield mannosyl-inositol-phospho-alpha hydroxyphytoceramide (MIPC). The enzyme is located in the Golgi apparatus, and utilizes GDP-mannose as the mannosyl group donor. It consists of a catalytic subunit (SUR1 or CSH1) and a regulatory subunit (CSG2).",384,0.99999994,-0.057660595,-0.055471584,-0.07677538,-0.04108836,0.030996129,-0.01925829,0.017785281,0.06268113,0.025513342,0.036403816,0.09101236,-0.047552135,-0.124197446,0.021532526,-0.040621262,0.0037512267,-0.0069657136,0.00858713,0.02645515,-0.014570792,0.025920544,-0.025680466,0.004713195,0.05440921,-0.057456836,0.001008875,-0.010472678,0.013216819,-0.0077930847,-0.0880112,-0.0047568353,0.037261393,0.054458722,-0.043132305,0.055099666,0.0808774,0.101386786,0.021623729,0.1027883,-0.050549798,0.02372971,-0.06897983,-0.00086375116,0.032914232,-0.06394341,0.03090819,-0.042764798,0.04560898,0.041431207,0.0046050646,-0.04829801,-0.028739057,-0.056886796,0.0002798359,-0.031703807,0.030418184,-0.07825295,0.013607631,-0.0019153071,0.058780495,-0.018140526,-0.033249635,-0.00022966208,0.10009878,0.012198295,-0.078726016,0.039953627,-0.030740755,0.062590845,-0.006023154,0.01207666,-0.106338,-0.047378853,0.034511432,0.021169947,0.09403113,-0.006384055,-0.07353326,0.059654392,0.0073013105,0.026756527,0.044857766,0.035539385,0.055604625,0.024801018,-0.009932407,-0.00047405055,0.046842206,0.072738566,0.010361741,0.04850218,0.053235084,0.012605363,0.0022044932,-0.01401576,0.05955461,-0.032740522,0.054532897,-0.024170542,0.019504279,0.047126733,0.020889252,0.022212476,-0.07826031,0.01940035,-0.004522586,-0.0017517168,-0.021181472,0.022097329,0.020247925,-0.040002294,-0.03308298,0.009292635,-0.013734601,-0.036850587,0.0036862013,0.035907727,0.0027140987,0.031137513,-0.068680674,-0.041433793,-0.015741566,-0.04663685,0.014459141,-0.099953,0.006163785,-0.060119264,2.0668743e-33,-0.00860574,0.01238665,0.049299587,0.018390568,-0.07229223,0.015384347,0.05265008,-0.05188129,-0.137823,0.0589692,-0.0774851,-0.08518115,-0.037074536,0.08995925,-0.07229493,-0.0007176917,-0.063222595,0.05775195,0.06328198,0.04132187,-0.022737164,0.07491192,-0.019919127,-0.09048018,0.1256842,0.082866035,-0.09548342,-0.039974894,0.055105064,0.011825058,0.113379374,-0.008937799,-0.0981185,0.025048092,-0.009218528,-0.018056793,0.036286186,-0.015661772,0.0042192885,0.049459178,-0.10489955,0.021581542,-0.02225308,-0.026411911,-0.012232389,0.036250547,-0.060228076,0.013497489,0.011011879,-0.014421437,0.018942634,-0.014694305,0.020326164,0.06483335,0.034454107,0.022225667,-0.01847445,0.0382899,0.055025563,0.106809296,-0.034195125,0.10150492,-0.068698995,0.046421327,0.06260166,-0.041507833,-0.08555231,-0.020027835,-0.050771862,0.0035096162,0.01586398,-0.029563276,0.051945604,-0.033772394,0.01731625,-0.068161316,-0.007172079,-0.0372798,-0.087862305,0.04726761,0.032976657,-0.060224492,0.0028129944,0.0092784,-0.093591824,0.021459755,0.026915766,0.009520996,-0.075402044,-0.038856603,-0.03151883,-0.049036033,-0.050186485,0.038748506,-0.0627524,-4.0864382e-33,0.055555254,-0.08811662,0.07169588,-0.120547526,-0.11491329,0.06089507,0.14807853,-0.06023053,0.05368933,0.04065918,0.043369014,-0.02762475,-0.040409718,-0.025133915,-0.031531133,0.03020708,-0.062720776,0.02005674,0.025115928,0.035361707,-0.013987204,0.08868667,-0.0023943912,0.12601738,0.023142116,-0.005646903,0.06598929,0.081093036,-0.015983546,0.010329419,-0.026008477,-0.041085564,-0.06524991,-0.04142068,-0.015850397,-0.0053433077,-0.10743149,0.027010657,-0.03134997,-0.013729283,-0.069920786,0.059603985,-0.026715443,-0.026357638,0.014672955,0.05329313,-0.0720999,0.0996368,-0.01158777,0.0017106092,-0.050710794,0.018478664,0.029130515,0.067241035,0.032433264,0.0155192865,-0.018064693,-0.0022419123,-0.036939632,-0.07090153,-0.025650306,-0.07727294,-0.016361529,0.009997744,0.079172336,0.11984835,-0.013887807,-0.040444337,-0.026649974,-0.0038876461,0.016877415,0.012465421,-0.038545635,0.012686285,0.0206057,-0.04861117,-0.06507751,-0.04108859,0.011863345,-0.012923778,0.049318373,-0.029890586,0.0015649748,-0.03917159,0.12919843,0.0038638315,0.0031518964,0.057183884,0.05093398,0.05313581,-0.0036492837,0.046232384,-0.06421877,0.051172353,0.04349662,-4.076392e-08,0.078429006,-0.07653666,0.085624166,-0.11712774,-0.04370766,0.0059375395,0.061436303,-0.031884406,0.020459194,0.002924712,-0.03867387,0.09559605,0.054330926,0.07563119,0.039795905,0.016931025,-0.015712487,0.031006522,0.00958598,-0.069800295,-0.052727852,-0.0055134194,-0.035355497,0.007573409,-0.022241237,0.0014650178,0.10585473,0.012000166,-0.016674208,0.028827298,-0.012374247,-0.0051089795,0.0064443466,0.013945636,0.010441473,0.07466242,-0.08134818,-0.030846078,-0.06805759,-0.015450765,-0.07199353,-0.06143369,0.013070506,-0.043786183,0.008518415,-0.0024408975,-0.0108019365,0.05864573,0.074688934,0.064941384,-0.025761975,0.07712019,-0.08994337,-0.03649825,-0.061072826,-0.023006294,-0.07470666,-0.00610877,-0.020826846,-0.027061814,0.02168824,-0.017151175,0.09599808,-0.06904082 +3.1.1.107,"This bacterial enzyme is present in pathogenic Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. Unlike EC 3.1.1.108, iron(III)-enterobactin esterase, which acts only on enterobactin, this enzyme can also act on the C-glucosylated forms known as salmochelins. Unlike EC 3.1.1.109, iron(III)-salmochelin esterase (IroD), IroE prefers apo siderophores as substrates, and is assumed to act before the siderophores are exported out of the cell. It hydrolyses the trilactone only once, producing linearized trimers.",384,0.99999994,-0.055464752,-0.07821861,-0.12612057,0.015278018,0.035687324,-0.021034427,-0.010564457,0.047582306,0.07236231,-0.030782644,0.017872531,-0.027733998,-0.08647166,0.0024494994,0.009780634,-0.0506462,-0.0095023215,0.035128817,-0.04090323,-0.007944212,0.07135662,0.01977094,-0.03470219,-0.02593923,-0.0882876,-0.0023684413,0.104588896,0.08090787,-0.0723909,-0.09910629,-0.040434483,-0.06424291,0.06901361,-0.041255035,0.052606747,0.09836266,-0.034822863,-0.14662611,0.025409803,0.02484499,0.0006497974,-0.045929197,0.00095348543,-0.026591586,-0.0155454725,-0.07760082,0.0064037545,0.017230958,0.09457184,-0.032465983,-0.09193026,-0.06592753,-0.032999225,0.06956411,-0.02540122,-0.0054936176,-0.07560085,-0.087936334,-0.051081784,0.00034888368,-0.0047161477,-0.039736528,0.07539679,-0.015078633,-0.08946664,-0.04931341,0.06809842,-0.10396922,-0.034395143,-0.05168293,-0.045598667,-0.0078014866,-0.072849475,0.066417955,0.014626479,0.04192857,0.089047045,0.06337976,0.02775577,-0.04482804,0.016884176,-0.012817267,0.06764477,0.10240948,0.0372437,-0.021274054,-0.00019650161,-0.03408084,0.009457695,0.09435765,0.03937725,0.008993508,0.045029435,-0.0577343,-0.027064867,0.008543234,-0.055682603,-0.020132521,-0.0017179648,-0.016703248,-0.08258868,0.05834144,-0.027326262,-0.05348746,0.013554633,-0.0015673441,0.0008007165,0.10835076,0.04934375,0.00472287,-0.025874367,-0.013136948,0.022927066,-0.050824706,-0.022707999,0.009550713,0.042439375,-0.041527417,-0.021646906,0.05357814,0.03641635,-0.008981406,0.04967084,0.06399808,-0.049544968,0.007107735,-0.07798107,3.8280205e-33,0.050410733,0.015218616,-0.019921135,-0.02133466,-0.070331074,0.0008253343,-0.106876984,-0.0037167573,-0.0047530015,-0.0761635,-0.064853735,-0.045580756,0.033456516,0.03168867,0.033158153,-0.057296332,-0.015011263,0.019402295,-0.021188784,0.02535044,0.0758943,0.02569092,0.047062207,-0.03188752,0.02200295,0.082873695,-0.013477795,-0.010538349,-0.0055854684,0.0031135445,0.07505887,-0.102936275,-0.097034216,0.028275728,0.056743983,0.030043978,-0.0019371863,0.0051371665,-0.013317671,0.04862053,-0.08524589,0.071692176,-0.034347337,-0.05478538,0.06821794,-0.10620433,-0.02969812,0.1166592,0.06201216,0.027331056,0.0053516026,0.03726289,0.13295873,-0.006931115,-0.04201176,-0.013723076,0.0103404,0.029472392,0.049859345,-0.0025378685,0.047091752,0.063757405,0.033115927,0.024937818,-0.03202434,0.08547632,-0.028462205,0.001429589,0.029471248,0.06433209,-0.016695138,0.045783352,0.030319404,-0.018190157,-0.038054686,-0.08937885,-0.059988033,0.000761135,0.09529436,-0.025087476,-0.007587972,-0.024399625,0.03518915,0.04496188,-0.1025213,0.03009035,-0.045642447,0.022475313,0.021517115,-0.004019097,0.102520294,0.013864695,-0.094215736,-0.022516614,-0.04561049,-3.6719244e-33,0.109892406,-0.048874468,-0.030568305,-0.06411694,-0.07173208,0.067162104,-0.026436664,0.06823018,-0.035980467,-0.020188944,0.09991013,-0.0042316383,-0.040673193,-0.08558089,-0.0068820366,0.037492428,-0.020085726,0.0211957,-0.02671488,-0.10010711,-0.051259283,-0.007919273,0.071371466,0.01820763,-0.028928185,-0.0053091445,-0.03440686,0.052781153,-0.023756275,0.02610202,-0.021870643,0.0030049048,-0.024557358,-0.1081116,-0.05108825,0.014353438,-0.026110921,0.03884226,0.07385811,-0.021294236,0.09816382,-0.017860964,0.007777819,0.08143584,-0.025632104,0.10762755,-0.050715033,0.005735723,0.011627956,-0.0029301392,-0.018741779,-0.031915274,0.010361857,-0.016465355,-0.012093201,0.012767596,0.036696497,-0.044397324,-0.0656354,0.04097383,-0.026949352,-0.029065385,0.11458378,0.048032038,0.05615876,0.078034155,0.011360187,0.060570147,0.029298589,-0.005247563,0.07010188,0.021064045,0.017880224,-0.070244245,0.015286666,-0.0123985475,-0.022932604,-0.033915866,-0.02969669,0.0005009596,0.001316713,-0.046417426,-0.09789218,0.0020416381,0.015978241,-0.07158516,0.041910827,0.023037307,-0.045003973,-0.0044521834,-0.020027833,-0.024765356,0.0032407683,0.084975064,0.05469694,-3.9252072e-08,0.023492385,-0.04956741,0.022604693,0.0049037146,0.02791386,0.05486987,0.0005357976,-0.028771102,0.032944307,-0.027192684,-0.034064654,0.13297655,0.03493624,-0.008743331,0.04359515,0.080396466,0.016827408,0.0006628485,0.013054877,-0.016612021,-0.043289073,-0.034919154,-0.03412512,0.005974845,0.0624614,-0.032288782,-0.027307969,0.0005150046,0.01323017,-0.027858377,-0.03530351,0.056189407,0.055475693,0.032301974,-0.08546688,0.032112353,-0.07916841,0.0024481132,-0.07026737,0.017395224,-0.03076169,0.040712483,-0.063241854,-0.015375641,0.018501686,0.03773643,0.00012380637,0.06434635,0.008396786,-0.06378295,0.033188492,0.003546696,0.053645022,0.043146107,-0.06683266,0.110288695,0.032062028,-0.09280054,0.10345569,0.03815178,0.06728183,-0.039065268,0.097454086,0.012820273 +3.1.1.108,"The enzyme, isolated from the bacterium Escherichia coli, allows the bacterium to grow in limited iron conditions. It can also act on enterobactin (with no complexed iron) and the aluminium(III) analogue of iron(III)-enterobactin. The trimer formed is further hydrolysed to form the dimer and the monomer.",384,1.0,-0.05430602,-0.06134931,-0.11181513,0.102043994,0.043657884,-0.018896896,-0.04932751,0.009784259,0.031305626,-0.027852247,0.012062721,-0.066892385,-0.06794134,0.026728371,-0.012785522,-0.064906545,-0.03694127,0.02015794,-0.065010205,0.008536917,0.022255177,0.05442696,-0.043547325,-0.014439463,-0.057756964,0.010874825,0.086636566,0.012495847,-0.008853771,-0.064761825,0.003801431,-0.030490955,0.116961114,-0.061793234,0.07177815,0.05073048,-0.0071071098,-0.05749088,0.06738968,-0.014607499,0.012594918,-0.014254952,0.036707606,-0.0319632,-0.022716695,-0.05606942,0.056443427,0.018875953,0.053895917,0.005312775,-0.06250101,-0.045026116,-0.048434027,0.08124596,0.015753506,-0.04739691,0.0021854246,-0.05176887,-0.04218748,-0.018807862,0.060361695,-0.047835957,0.05375215,-0.014696358,-0.016217077,-0.051964123,0.06668262,-0.052301936,-0.037562024,-0.08467412,-0.032436766,0.010222321,-0.055292357,0.08323598,-0.019577468,0.0316466,0.01786114,-0.016731018,0.062456425,0.051810626,-0.049490903,-0.014749948,0.006546703,0.11403559,-0.033025194,0.03584575,0.047133453,0.011929218,0.008828983,0.08976767,0.0072356397,0.03376594,-0.005367365,-0.120794535,-0.028895313,-0.032137923,-0.01911219,0.0032085022,0.018816674,-0.007658012,-0.037714075,0.066062555,-0.005848852,-0.052300856,-0.022185052,0.007667179,-0.018643029,0.11321789,0.06894928,0.019931735,0.021472292,-0.0003213651,0.069613725,-0.011991872,0.0030192866,-0.0027490882,0.11214898,-0.09875914,-0.042587288,0.07573205,0.05322991,-0.0036768743,0.036821865,0.070690274,-0.038032334,0.023879988,-0.078999065,-9.253737e-34,0.013052653,0.0038598198,0.019525874,-0.0045293053,0.013534484,0.01082046,-0.07614613,-0.013321635,-0.064619884,-0.0019989694,-0.069002144,-0.09497586,0.11424384,0.020960206,0.03759852,-0.0298793,0.0074270945,0.0067199217,0.02477564,0.021870809,0.03357993,0.09640373,0.023348007,-0.0054328335,0.03310401,0.077543594,-0.0025210432,-0.024265744,0.00074345694,-0.020456897,0.03560827,-0.07845174,-0.15085286,-0.011992538,0.12811244,0.0112656765,0.016155375,0.011545214,-0.03350239,0.0074783997,0.052951466,0.052615236,-0.01958038,-0.019400574,0.09629563,-0.056618884,-0.06191362,0.116510324,-0.00023768588,0.037776347,0.035001375,0.026116569,0.08026974,-0.071948916,-0.081455864,0.024125196,-0.014317386,-0.020803407,0.037886582,0.051176146,0.00026577222,0.05134898,-0.037334114,0.12158508,-0.017615661,0.010458577,0.015267414,0.0091924975,0.019470684,0.11153993,-0.0682701,0.022512754,0.014368812,0.016032796,-0.041170325,-0.0552499,-0.10312019,-0.05489436,0.10683173,-0.010073557,-0.0128337685,-0.03137714,0.017388245,-0.035378166,-0.100726284,0.01979329,-0.064751886,0.008191246,-0.003705201,-0.034134667,0.080435865,-0.047315832,-0.096335515,-0.008315844,0.015866077,-2.120367e-33,0.06976557,-0.079777114,0.0056727584,-0.10100542,-0.07903347,0.047399905,-0.05937506,0.0139465565,-0.03707247,-0.04646156,0.10006224,0.01749825,0.018315375,-0.08155429,0.039646093,0.016515177,-0.010478059,0.030676864,0.0038755226,-0.057890642,-0.008864542,-0.01692046,-0.005069046,-0.054330952,0.014434958,0.013794715,-0.0972803,0.07361864,0.032258727,0.11277477,-0.015264795,-0.016384121,-0.010828483,-0.10679975,-0.06433879,-0.0031026488,-0.026123941,-0.005805986,0.07526627,-0.063074514,0.024868786,-0.01100517,0.057084717,0.1172798,-0.0060871695,0.056192163,-0.033298783,0.022466596,0.009231035,0.02790797,-0.0020773425,-0.070168994,0.00046651132,0.0025134948,0.02954626,0.030184997,0.042355172,-0.0050243516,-0.08843977,0.042543806,-0.047546327,-0.0403116,0.099913836,0.0021448329,-0.0009125506,0.045536544,-0.014240062,0.073631406,0.005128148,-0.0773682,0.07448488,0.021833722,0.0523772,-0.03118518,0.009803437,-0.017846322,-0.021425823,0.013256882,-0.050189693,0.07042416,-0.010419358,-0.0013939058,-0.03083052,-0.047704104,0.02201772,-0.11115459,0.020229463,0.017909423,-0.04160358,0.018357737,-0.109323956,-0.01574662,-0.019181157,-0.009846837,-0.03218277,-3.8613766e-08,-0.049644437,-0.034419604,0.026167229,-0.058180004,0.01696637,0.0541782,-0.0352729,-0.044343475,0.045151833,0.053568162,-0.014487089,0.090964854,-0.02948752,0.018730944,0.033468395,0.032320883,-0.027102925,-0.008609477,-0.010212718,-0.023873497,-0.05676994,-0.0004867923,-0.009834953,0.00013270752,0.01453382,-0.09063745,-0.078365274,-0.022442313,-0.0032659234,0.027179863,-0.05307318,0.071181744,0.02118544,0.00516425,-0.1100087,-0.01954667,-0.045248054,-0.031579148,-0.03438433,-0.012180442,0.024479087,-0.010816217,-0.10956563,-0.03781232,-0.0068835523,0.016730824,-0.036598213,0.04108667,-0.051941454,-0.018940747,0.09688721,-0.0015453218,0.053310957,0.043390337,-0.046517227,0.108263254,0.030153075,-0.090467416,0.034939542,0.060764752,0.003108489,-0.046106454,0.14029656,-0.0069528576 +3.1.1.109,"This bacterial enzyme is present in pathogenic Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. The enzyme acts on iron(III)-bound enterobactin and C-glucosylated derivatives known as salmochelins. Unlike EC 3.1.1.107, apo-salmochelin esterase (IroE), IroD prefers iron(III)-bound siderophores as substrates, and is assumed to act after the iron-siderophore complexes are imported into the cell. It catalyses several hydrolytic reactions, producing a mixture of iron(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] complex and salmochelin SX.",384,1.0,-0.038853917,-0.05090131,-0.12636313,0.04926961,0.097433515,0.0011888973,-0.019595195,0.022679811,0.07683364,-0.06124927,-0.03674809,-0.018849982,-0.02004546,-0.0058767344,-0.015785197,-0.042103782,-0.022012396,0.061063588,-0.03530202,0.031161828,0.051642966,0.009076412,0.0017254603,-0.037506353,-0.080221176,0.021398352,0.12556373,0.05697697,-0.095386595,-0.04709403,-0.045881458,-0.0765877,0.07386867,-0.063388236,0.050417382,0.09980008,-0.018908301,-0.12591965,0.03461334,-0.011628417,-0.012769504,-0.021607937,0.018008776,-0.04470648,-0.02515454,-0.09204983,0.04511285,0.0053499965,0.09544198,-0.02424829,-0.08525058,-0.060228895,-0.023058457,0.050216384,-0.010081582,-0.012752766,-0.08496255,-0.108640596,-0.050306253,-0.0062968903,0.0001733399,-0.06924385,0.06629059,-0.054826412,-0.08607374,-0.045502175,0.05429104,-0.080180846,-0.0102167465,-0.06273664,-0.057319198,-0.0013029274,-0.06763341,0.031235075,0.021632366,0.034185268,0.111754306,0.057648335,0.06200824,-0.03781076,0.009025707,-0.017835964,0.07687456,0.10220148,0.039217457,-0.0047861803,0.005085317,0.0071687293,0.055992182,0.09308899,0.0042766724,-0.01533409,0.01280677,-0.042172752,-0.042120263,-0.025692245,-0.0430054,0.014735573,-0.003255664,0.0021694768,-0.06616277,0.08492452,-0.020503184,-0.08884692,0.07023237,-0.007487864,0.00013807985,0.15678503,0.022859918,-0.02494282,-0.0068900543,-0.031754564,0.04000489,-0.03602258,-0.013897144,0.021282911,0.034219813,-0.034121364,-0.071582995,0.0192331,0.07101401,0.027177805,0.036955472,0.062439345,-0.06045471,0.003006669,-0.08945417,2.9332002e-33,0.011245754,0.012334486,0.0037797978,0.020902885,-0.042507686,-0.034625966,-0.09424068,0.00077154965,0.012341475,-0.03615681,-0.0751737,-0.054589324,0.012452441,-0.008120343,0.03299353,-0.077458076,0.0075217136,-0.031172188,0.032413073,0.01667389,0.05198166,0.017765107,0.067992285,-0.037071962,0.0028105786,0.07127286,0.024713345,-0.00083740574,0.031470142,-0.008113683,0.07322678,-0.08699858,-0.08872695,-0.014870685,0.07507425,-0.0009027941,-0.011283693,0.0036599184,0.0072533404,0.043913387,-0.09875095,0.070028804,-0.058806468,-0.03537095,0.063075654,-0.07310989,-0.02473366,0.101063736,0.05579572,0.022005841,-0.022850765,0.025836173,0.123413734,-0.0043868716,-0.0842101,-0.025275309,0.030062996,0.05734566,0.052369885,0.02324907,0.017066909,0.055000886,0.05293859,0.042260934,0.009927815,0.08408372,0.0012187045,0.025401594,0.01798342,0.07161353,0.0039201025,0.08075549,0.05126261,-0.020482011,-0.039257847,-0.08712855,-0.050114587,-7.7998564e-05,0.0809096,0.0062640286,0.016584687,-0.0052409507,0.021745348,0.041392345,-0.10200422,0.018861983,-0.07304945,0.026744584,-0.0032399578,-0.0031389922,0.05288068,0.019088296,-0.07509282,-0.030779757,-0.061707534,-3.5150066e-33,0.09680198,-0.08111028,-0.012836224,-0.09032855,-0.09798372,0.048888184,-0.03677117,0.02989532,-0.021527534,0.023987345,0.06963586,-0.036451474,-0.0103089595,-0.0948069,-0.010961235,0.038784634,-0.023575228,0.045788404,0.00020596672,-0.09008193,-0.058802813,0.01590013,0.07160937,0.0053330557,-0.022392642,-0.0040264293,-0.0018713882,0.03813784,-0.017788157,0.0590079,0.023016755,-0.013391244,-0.015483203,-0.111782916,-0.06153504,-0.004111532,0.0053732404,0.034280263,0.07322428,0.013671376,0.09341262,-0.04580024,0.002975018,0.069591865,0.017575633,0.07839876,-0.088346936,-0.0003611263,0.009566332,-0.030958485,-0.0054274313,-0.04666904,0.0020045186,-0.05949051,-0.013357504,0.013599291,0.05238515,-0.04486975,-0.01952336,0.00041558078,-0.014030276,-0.02748397,0.09682378,0.048266247,0.036897164,0.10592913,0.025526376,0.029439788,0.05938035,-0.018826561,0.048385333,-0.0144877955,0.035268445,-0.021886958,0.045573875,0.015923379,0.007989979,0.011750509,-0.030451562,0.018901078,0.029553171,-0.07551121,-0.05430485,-0.006191852,0.016611561,-0.06466486,0.07478996,0.047759775,-0.053393397,-0.018316617,0.00366615,-0.02984044,0.0026526682,0.051950406,0.032560535,-3.6842213e-08,0.029581448,-0.0946703,-0.0050715646,-0.028501738,0.00026257845,0.0500027,-0.036598958,-0.06466716,0.014338743,-0.029230896,-0.039039817,0.11778819,0.023138342,-0.007629687,-0.015553077,0.052207988,-0.0051793125,8.256506e-06,0.016499104,-0.013688231,-0.05972755,-0.011213981,-0.034625046,0.0056809373,0.07562165,-0.069028996,-0.037562847,-0.03201331,-0.015153531,-0.05026636,-0.04192267,0.038976002,0.007707587,0.020661391,-0.07000422,-0.003120915,-0.090951264,-0.030068338,-0.016476387,0.04322853,-0.021726757,0.043460466,-0.03930308,0.0036243827,0.0025254132,0.058638692,-0.0010136798,0.08252365,0.022266176,-0.048695695,0.042153273,0.0273083,0.0461482,-0.0027745902,-0.079880826,0.15516382,0.030770462,-0.08964909,0.09045056,0.0046484224,0.06489554,-0.050620347,0.05355186,-0.01203179 +3.1.3.106,"The enzyme has been studied from the plants Arachis hypogaea (peanut) and Arabidopsis thaliana (thale cress) and from the yeast Saccharomyces cerevisiae. The enzyme from yeast, but not from the plants, requires Mg2+.",384,0.99999994,-0.099994615,-0.04156952,-0.07940974,-0.0022693144,0.049314957,-0.0051555014,-0.08191534,0.008479063,-0.031660456,0.04698155,0.018075272,0.007479096,-0.084336974,-0.05113842,-0.017358389,0.0155399935,-0.0058131246,0.10712316,0.018891167,-0.08475814,0.122495644,0.005899776,0.024410745,-0.02904392,0.034210395,-0.019338887,0.0369642,-0.011702407,0.039180122,-0.044014588,-0.04161817,-0.025277734,0.09070435,-0.03384157,0.025582371,0.08717667,-0.030101072,-0.049236234,0.051779956,-0.043410026,0.025602976,-0.016528146,0.033195477,-0.030104455,-0.08123954,-0.08927244,0.043123066,-0.022313144,-0.010080952,0.027956627,-0.071188286,-0.0151342815,-0.031686928,-0.051119532,-0.0073377276,-0.0001224045,-0.019247605,-0.011198155,0.028927438,0.03176365,-0.011092181,0.010558656,-0.016707348,-0.014697389,-0.001521565,-0.013779472,-0.027503952,-0.004511415,0.06016977,-0.08289946,-0.0051812106,-0.060383737,-0.05613758,0.022566868,-0.063131556,0.034463577,0.035020728,-0.01748871,0.063303754,-0.0046230387,0.008134932,-0.03186613,0.118824385,0.048023243,0.022126649,0.031819925,0.0066677695,0.1221573,0.04084709,0.018855467,0.10826359,0.045146402,-0.032293506,0.019567681,-0.007946198,0.0667785,-0.03113173,0.001355881,0.023703834,-0.017048659,0.03389576,0.07967354,0.0049111205,-0.052978117,-0.0035498398,0.08734727,-0.043238062,0.02117433,0.034043998,0.050346825,0.034605306,0.065847114,-0.031147053,0.01833642,0.041780464,-0.0100612305,-0.016272934,-0.08427006,0.01228646,-0.01881307,0.020410506,0.017273493,0.016463649,0.008328197,-0.013492351,0.06336651,-0.110740475,3.503059e-33,0.005917851,0.04183981,0.0014525243,-0.036025595,-0.0547363,-0.017639117,-0.03158671,0.031859905,-0.042064175,-0.027222324,-0.09686636,-0.0860746,-0.023730494,-0.026308628,-0.032934844,-0.014079747,-0.0054272055,-0.034009863,0.089758076,0.06165037,-0.042644914,0.04210967,-0.057658557,0.010986911,0.015099116,0.087271385,0.031675197,-0.059147853,0.08262263,-0.009437529,0.04635065,-0.13634083,-0.059310418,0.030889237,0.052203845,-0.0011448195,-0.021932947,0.005663826,-0.069614984,0.041277897,0.010532178,-0.012721688,0.014544227,-0.034724474,0.04515419,-0.03145479,-0.024902523,0.024428818,0.066061676,0.06411412,0.018767383,0.04329683,0.05529064,0.021740621,-0.066666864,0.03981029,-0.005607057,0.082627565,0.08300308,0.03411592,-0.06846135,0.025778022,0.026793465,0.0648259,0.06949929,0.055157375,-0.14026877,-0.09327023,-0.021198204,0.110363565,-0.028651603,-0.082542084,0.03313527,-0.017558817,0.03806241,-0.045060784,-0.043629657,0.034469098,-0.0099333385,0.026153212,0.05211193,-0.026130782,0.03179497,-0.032633826,-0.12207251,-0.014705918,-0.07600564,-0.026939552,0.0009256327,-0.030753488,0.06714786,-0.039700616,-0.03222134,0.030637642,-0.0050354674,-4.1181913e-33,0.06829807,0.0034850538,0.11520525,-0.051628705,-0.091892764,0.07993236,0.057510715,-0.06536401,0.009778924,0.036203552,0.07285708,-0.03352852,-0.012191071,-0.09127383,0.046783112,-0.013113571,-0.00047922088,0.07868223,-0.015142635,0.003027137,-0.059755575,0.12680474,0.018032331,0.0014862791,0.07421794,0.01616495,0.067034304,0.08371361,0.022287551,-0.009188957,0.019864326,0.048853654,-0.0056387493,-0.01676222,-0.07568765,-0.0039504482,-0.057745483,-0.015193163,-0.021170588,0.06393119,0.01581534,0.08143917,0.03613961,0.08506364,0.014692711,0.030562757,-0.050430123,0.054080173,-0.022098467,-0.07658991,-0.017284201,0.00075193186,-0.050447397,-0.041943602,0.075902574,-0.0080139395,-0.0067139766,0.026358716,0.0014931841,-0.021546783,-0.0052799694,-0.06734169,0.043937124,-0.0036912537,0.050608173,0.09285653,0.0072678174,0.03450582,-0.025397165,0.09683448,0.09024249,0.06966035,0.0473966,0.088439,0.017686862,0.084605575,-0.044288654,-0.045290537,-0.06424538,-0.085089065,0.056118816,0.015922636,0.0044907033,-0.004871426,0.002204748,-0.12579456,-0.0135992225,0.07350486,0.0224399,0.026495226,-0.051132347,-0.06667792,-0.07954152,0.02180417,0.07002162,-3.7664783e-08,-0.01910801,-0.03308553,0.056486838,-0.08382077,0.025181245,0.0831483,-0.008065997,-0.0335497,0.038115617,0.036749817,-0.078420356,0.028711755,-0.010227139,0.052701347,-0.009180744,-0.03711392,0.025962682,0.03338615,-0.030213363,-0.01717528,-0.04979424,-0.0020680658,-0.10888065,0.049273897,0.020364782,-0.050551422,-0.025420109,0.025850309,0.044289857,-0.00082784914,-0.040746525,0.02845401,0.03286978,-0.07678281,-0.046053167,0.041531853,-0.05056792,-0.04864356,-0.05638923,-0.0815218,-0.0026066469,-0.057690278,0.050703704,-0.019878142,-0.06985822,-0.05802059,-0.01044119,0.008043706,0.0064049433,0.023628302,0.024923243,-0.019044649,-0.07986941,-0.10776621,-0.07562471,-0.0447536,-0.025649434,-0.085595615,-0.047655914,-0.11335118,0.022531932,0.0054337964,0.12076218,-0.046611737 +3.2.1.209,"The enzyme, located in the endoplasmic reticulum, primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 isomer 8A1,2,3B1,3 (the names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7]). The removal of the single mannosyl residue occurs in all eukaryotes as part of the processing of N-glycosylated proteins, and is absolutely essential for further elongation of the outer chain of properly-folded N-glycosylated proteins in yeast. In addition, the enzyme is involved in glycoprotein quality control at the ER quality control compartment (ERQC), helping to target misfolded glycoproteins for degradation. When present at very high concentrations in the ERQC, the enzyme can trim the carbohydrate chain further to Man(5-6)GlcNAc2.",384,1.0,-0.0008990909,-0.03901345,-0.04515278,-0.0444338,0.0061098803,-0.01062448,0.0013288542,0.055778965,0.013717275,0.02036323,0.032542754,0.027541598,-0.11968056,0.018863054,-0.07581353,-0.041704763,-0.016719079,-1.48642885e-05,-0.02456976,-0.07438078,0.14136322,0.031217411,-0.0031004671,0.013610257,0.011663024,-0.13734229,-0.031523313,-0.030185219,-0.0065882104,-0.17171931,0.010636357,-0.054173604,0.060776163,-0.058454722,0.063897684,0.059277,0.046876844,-0.037180245,0.021431826,-0.028933864,0.002494303,-0.03665909,-0.08236399,0.00031751467,-0.050765075,0.037384048,-0.020516695,0.031501763,0.033597745,0.06581093,0.021548545,-0.06377777,-0.073791645,0.0142303305,0.04569175,0.02421621,-0.06065552,0.0019084614,0.008651851,0.068645254,0.019734561,0.020785008,0.035354864,-0.021564158,0.07728334,-0.10481639,0.12847859,-0.08408139,-0.0075797746,0.04201135,0.017233882,-0.080890834,-0.11435479,-0.01913971,-0.0009777143,0.058801852,-0.08534452,-0.021746721,1.8470786e-05,0.030585138,0.07307387,0.0230665,0.118532024,0.040048487,-0.035909217,-0.020913834,-0.043085843,-0.0005806273,0.09914951,0.0061103394,0.0521778,-0.017972168,0.09110711,0.0050966977,0.05928174,-0.018516691,0.0066786986,0.046640344,0.026510771,-0.013462906,0.063065186,0.019157078,0.01807863,-0.05716409,-0.008559185,0.07365726,0.010917881,0.053615533,0.05388819,-0.0044149947,-0.048740685,0.081220515,0.022302553,-0.036655724,-0.067178495,0.021379674,0.06536205,-0.009663223,-0.057767414,-0.024489205,-0.041782606,0.044322714,0.04860424,0.049347106,-0.0030810735,0.030000068,-0.05302095,2.7064317e-33,-0.0077032507,0.0022880407,0.041070312,0.033072837,0.0139145125,0.009844024,-0.044755947,-0.030160686,-0.0558376,-0.014982235,-0.053507898,-0.041825604,-0.031198168,0.09120362,-0.051800936,0.03267935,0.02711273,0.022141794,-0.02969798,-0.016661378,-0.047326535,0.017067982,-0.008991508,-0.040724616,0.09783108,0.07852282,-0.048313953,0.052301813,0.023535863,-0.038438715,0.027402472,-0.06343519,-0.09522652,0.037177205,0.07778208,-0.0010901992,0.01999516,0.030294951,0.024044918,0.027378103,0.033329736,0.057328574,-0.038391333,-0.04689792,0.04076674,-0.058722254,0.015868662,0.063051105,-0.015520116,0.019194204,0.042338938,-0.015078909,0.04586996,0.042190626,-0.06542899,0.023781408,0.023492733,-0.032737937,-0.00056813535,0.07917825,0.020894494,0.06931237,0.0010240416,0.011355059,0.035684433,-0.0005445493,-0.09315071,0.028360104,0.0038343107,0.03272516,-0.053772695,-0.062184747,0.116578706,0.04216307,0.014147994,-0.09715211,-0.09608174,0.029833619,-0.017222391,-0.011594542,0.004671967,-0.020728283,-0.030474834,-0.018724544,-0.10636923,-0.04634265,0.032404464,-0.099841796,-0.07295917,0.03787306,0.0498864,-0.04608043,-0.039475724,0.10594675,-0.03367057,-5.3767934e-33,0.11855745,-0.06847049,0.0877107,-0.043286595,-0.046545196,0.0060879453,0.121675886,-0.014986608,-0.013537188,-0.044070445,0.039418727,-0.025705535,0.048384473,-0.015818642,0.04721421,-0.010778619,-0.017952133,0.07362346,-0.06032916,-0.007885027,-0.025935484,0.009687221,0.0029537217,0.006905969,0.021615343,0.0035669263,0.024477223,0.04308623,-0.0074123126,0.011803197,-0.0543969,-0.026554503,-0.057973012,-0.060200177,0.00092298223,-0.028482636,-0.06791345,0.054492455,-0.01305803,-0.054824557,0.0017505886,0.07128551,-0.059609152,-0.012503756,0.033657752,0.08934375,-0.057397045,0.019662937,-0.07120092,-0.053042203,0.024799589,-0.001111033,-0.045742195,0.077127665,0.034570098,0.074676864,0.0025565617,0.013144813,0.005808075,0.05917603,-0.045137644,0.04742491,0.025640516,-0.016591767,0.047651872,0.024280628,-0.008744195,-0.012442992,0.014519286,-0.031308148,0.042119462,-0.025748923,0.045067336,0.005728858,-0.037998322,0.0024998384,-0.11147377,-0.08196128,-0.0013943601,-0.11123026,-0.052751843,-0.08830848,-0.010408196,-0.014152211,0.017349787,-0.092728496,0.06041604,0.10774102,0.005506104,0.082468554,0.019337501,-0.06197361,-0.059472527,0.08052487,0.04732804,-4.5488683e-08,0.07379174,-0.034324337,0.015328834,-0.107272744,-0.031097509,-0.013197271,0.027721595,0.08266164,0.019725142,0.02259809,-0.010053464,0.07971995,-0.045482706,-0.0020810554,0.018114107,0.006912545,-0.047890514,0.07726607,-0.01570456,0.0040007494,-0.13081487,0.0011622085,-0.04791955,-0.0114222355,0.008514539,-0.039895214,0.06279871,0.1317229,-0.005638192,-0.0445251,0.06131496,0.056541573,0.028779877,-0.026975423,-0.02964158,0.008434827,-0.05537117,-0.006701717,-0.01597653,0.013536922,-0.03139664,-0.020644898,-0.010426304,-0.011513984,-0.00089452043,-0.027134325,-0.0025884542,0.040134925,-0.00072715135,0.06909597,0.03595723,0.02755947,-0.075477324,-0.06870203,-0.09475829,-0.054586746,-0.041000117,-0.0128235845,-0.031765666,-0.03652355,0.026554298,-0.069118775,0.09801627,-0.10668641 +3.5.1.133,"Requires Zn2+. The enzyme, characterized from the bacterium Corynebacterium sp. Ax20, hydrolyses odorless Nalpha-acyl-L-glutamine conjugates of short- and medium-chain fatty acids, releasing axillary malodor compounds. While the enzyme is highly specific for the L-glutamine moiety, it is quite promiscuous regarding the acyl moiety. The two most common products of the enzyme's activity in axillary secretions are (2E)-3-methylhex-2-enoate and 3-hydroxy-3-methylhexanoate.",384,0.99999994,-0.073610045,-0.08072456,-0.046244618,0.037577394,0.0715107,0.008421833,-0.012099656,0.042611044,0.0403703,-0.026709719,0.03292637,-0.08530188,-0.06045508,0.052627914,-0.02525705,0.018310657,-0.048939504,-0.05149148,-0.035102263,-0.055622835,0.17583856,0.11073489,-0.014779576,-0.054398097,-0.004209605,-0.04015251,0.046159334,-0.056627642,0.03394561,-0.050289683,0.032943364,-0.039820973,0.017087603,-0.045482203,0.06987953,0.022505837,-0.05710524,-0.06262157,0.08956809,-0.018976131,0.080281146,-0.006221406,0.0006208762,0.014053282,-0.06540069,0.036746312,0.05524938,0.053841725,0.045016285,0.05031115,-0.01420717,-0.11309367,-0.021334842,0.06263667,0.06433713,0.04222872,-0.1504921,-0.06771116,-0.037560385,0.06789191,0.05942596,0.029244976,-0.021934127,-0.0034917125,-0.025541738,-0.049184807,0.030300343,-0.090053685,0.044989206,-0.02779735,-0.04127315,-0.062656574,0.021282848,-0.00013726248,-0.042642817,0.041719846,-0.0029456918,-0.06244325,0.033347636,-0.029428238,0.04515427,0.0017067788,0.066524066,0.12182834,0.023348555,-0.06822705,0.04541095,-0.026542775,0.02317346,0.0024560275,0.015483325,-0.0002883439,0.00067469856,-0.08590342,-0.02316888,-0.007632005,0.06789495,-0.0023295516,-0.063977435,0.029848369,-0.031647727,0.053283993,0.019603074,-0.08040962,-0.0637358,-0.009436145,0.0514224,0.010700473,0.020153109,0.09769016,-0.014234866,0.024614055,-0.0037639162,-0.020162476,-0.056391064,0.035662334,0.047623932,-0.076544456,-0.09126823,0.004852094,-0.047936942,-0.07112636,0.03621946,-0.013623411,-0.026932364,0.03506565,-0.07025861,3.134356e-33,-0.03684782,0.021554789,-0.08104596,-0.032871306,0.009729826,-0.010390113,-0.036355436,0.07476286,0.027835328,0.034990355,-0.114590846,-0.08922453,-0.01477155,0.0800461,0.024906525,0.04759085,0.017967872,-0.04255957,0.0952293,-0.0055656494,0.0771638,0.021653019,0.03147076,-0.01786711,-0.021950811,0.008912245,-0.0043391134,-0.04189118,0.039805442,-0.028220596,0.074433126,-0.07448857,-0.037013784,0.022777567,0.05648904,0.05137362,-0.03404546,-0.026383832,0.026342997,-0.0023457664,-0.023274787,0.07058698,0.03343697,-0.042131647,-0.0074508623,-0.010770049,-0.105954565,0.019757641,0.059003573,0.00017224166,0.08202046,-0.016592618,0.005406116,0.053914588,-0.023248348,0.011732669,-0.061577078,0.02918302,0.03157495,-0.010442281,0.0140315555,0.037833218,0.015995575,-0.014050274,0.015463499,0.07372397,-0.07760269,-0.04798973,0.047852,0.014400469,-0.047500964,-0.005375382,0.021545852,-0.012655303,-0.0020785623,-0.01024486,-0.04002305,-0.00791822,0.07726295,-0.025899442,0.016777173,-0.056571145,0.092226915,0.059447907,-0.088647686,-0.088256195,-0.053740896,0.038087446,-0.012535607,0.016215798,0.005628962,-0.04439133,-0.023826735,0.032769956,-0.012028281,-4.205225e-33,0.09717411,-0.029121334,0.03350883,-0.07591706,0.04485334,0.07350671,0.016059723,-0.020589778,-0.015803035,0.023428991,0.06857334,0.107928306,0.06007835,0.01835738,-0.0020785725,0.027256688,-0.007789898,0.07400237,0.02565562,-0.1080714,0.0031468333,0.090308435,0.0028064665,0.008228701,0.061465386,0.0030347907,0.031619214,0.011707075,-0.028222445,0.10228311,-0.025438048,0.049403645,0.016768489,-0.09624801,-0.06301365,0.011623255,-0.036672585,-0.043669466,-0.055715017,0.0078827515,0.06567754,0.0031912478,0.01166227,0.036880918,0.019743506,-0.035435062,-0.071400926,-0.085873716,-0.00873437,-0.06050098,0.051331006,-0.043199204,-0.05813362,-0.020262798,0.04161685,0.15922952,0.03619542,-0.03302951,-0.028660871,-0.023853926,-0.071767636,-0.017118955,-0.035243485,-0.06873899,0.054861806,0.039640475,0.005200884,0.05800835,0.0016176148,-0.00040438378,0.049279846,0.035649065,0.021913059,0.05555923,-0.093168825,-0.020721328,-0.022554886,-0.05624643,-0.0042119306,-0.057509918,0.04043015,-0.04446088,-0.001695101,-0.0038891179,-0.02784572,-0.040485058,0.040739052,0.0808567,-0.028995203,0.025247747,-0.034619745,-0.021252237,-0.0592232,0.044485405,0.093936905,-4.7494733e-08,-0.016573822,-0.043018684,0.03980413,-0.03071666,-0.01975338,0.054765467,-0.020911247,0.03690639,0.027026385,-0.06281525,0.013632741,0.07258459,-0.035179436,0.066092946,0.014163141,0.03627331,-0.07200964,-0.0060533066,-0.06519032,-0.06278121,-0.09452118,-0.006655723,-0.08565306,0.0021042726,-0.012945278,-0.14902532,0.006039625,0.0814037,-0.04441889,0.031863052,-0.023277313,0.05401849,0.06720432,-0.028871456,-0.060066864,0.039045278,0.022995004,-0.082774706,-0.020787042,0.034362625,0.00073999446,0.04475271,-0.03032761,0.007466577,0.011658683,-0.026898418,0.06664104,0.027341804,-0.01657313,0.030803008,0.041253548,0.011405662,-0.03849829,0.021966401,-0.025658984,-0.054748986,-0.10931952,-0.05774149,0.022873022,0.005995048,0.06519389,0.004438899,0.1888918,-0.009734927 +4.2.3.204,"The enzyme was characterized from the trees Camellia hiemalis and Camellia sinensis (black tea). The enzyme from Camellia hiemalis produces (2Z,6E)-hedycaryol as a minor product.",384,1.0,-0.04201283,0.009485709,-0.092320375,0.017764904,0.032870773,0.060619477,-0.08301565,-0.013190445,-0.015607842,0.009282423,0.00067889015,-0.040708043,-0.010655986,-0.028858101,-0.008964544,0.013978854,-0.056496885,0.010993943,-0.06254996,-0.12457488,0.08498188,0.06382149,0.045955013,-0.0030048282,0.04178048,-0.027127726,0.05745267,-0.0045929295,-0.029127317,-0.09191834,-0.048882525,-0.0071551036,0.023237506,-0.06441411,-0.048331264,0.010036561,0.017708346,-0.063712835,0.096458785,-0.0055361935,0.05771296,-0.009038951,-0.023708127,-0.020720273,-0.059986707,-0.04462196,0.040608577,0.061409414,0.07578462,0.022892635,-0.08789177,-0.068930045,-0.063122824,-0.046897408,0.009092364,-0.08628914,-0.078296944,-0.026205787,0.016830508,0.02573531,0.034373544,0.015676726,-0.008941427,0.0068358993,0.011214797,-0.025206525,-0.025317483,-0.07977743,0.017403586,-0.05832801,-0.07885181,-0.05573256,-0.030000174,0.063867696,-0.08262247,0.049261414,-0.00324983,-0.037419345,0.03274643,0.036026545,-0.010317475,0.022089098,0.027948992,0.13576476,0.03654301,0.025940211,0.013545882,0.074826434,0.022611788,-0.018833626,0.06659554,-0.012338535,-0.058728833,-0.030829765,-0.11098119,-0.025845021,0.02731338,0.012256369,0.00236331,-0.0047482657,0.0073060556,-0.039034028,0.091621436,-0.06570598,-0.067172736,0.061032873,-0.11670779,0.0177417,0.10720875,-0.01168701,-0.028024478,0.010563547,-0.041722845,-0.008041602,-0.062321644,0.09945333,-0.03871171,-0.05780433,-0.11254256,-0.012754033,0.010698011,-0.0013000206,0.11434556,0.028664362,-0.020863948,0.06814213,-0.09169169,9.876756e-34,-0.034710977,0.027076332,0.048195936,0.018226879,0.0023920175,-0.011978268,-0.06721788,0.048288103,-0.06449136,0.008653338,-0.11434314,-0.034073994,0.042679537,0.019154685,0.028818756,-0.0033088268,0.048427433,-0.049813416,0.03177094,0.04801021,0.014528738,0.08727728,-0.04469733,0.018218657,0.0022360834,-0.0027935093,0.047403127,-0.00014172825,0.045665283,0.016072638,0.0808519,-0.12016903,-0.035781074,0.0023855043,-0.019629909,-0.050013807,-0.051094554,-0.0628904,0.016782897,0.02282412,0.033122,0.041692615,0.04397274,0.014868033,-0.013797937,-0.07688703,-0.023237007,0.023610454,0.09717079,0.02539412,0.008895365,0.040394336,0.17355683,0.0077953245,-0.04167035,0.064035624,0.040072683,0.100698456,0.08393664,0.083065294,-0.0003247536,0.026786713,-0.021691894,0.007595169,0.008309781,0.024555355,-0.06579364,-0.058726322,0.0035376803,0.071939796,0.011361126,0.017025292,-0.003113257,-0.027678603,0.08999295,-0.057745393,0.025285965,0.009161612,0.06774478,-0.007024419,-0.031625796,-0.0069598793,0.049578357,-0.01422036,-0.080818884,-0.063121326,-0.073241726,0.042222135,-0.06607205,0.03288526,0.051280454,-0.004865375,-0.09114007,0.004217898,0.050732944,-2.494735e-33,0.048997957,-0.031999916,0.029890295,-0.057786576,-0.049059443,0.08058286,0.07124175,-0.002251279,0.0069731497,-0.0020658884,0.12088987,0.013362159,0.0829027,-0.014256332,0.040789317,0.018671086,0.007929201,0.10393114,0.025897875,-0.020977776,-0.03673343,0.10209369,0.010872961,-0.07555296,0.025361508,-0.044026267,0.0428817,0.024665479,0.016262792,0.082955875,0.024774946,0.024164397,-0.0029291431,0.00774212,-0.046694074,-0.052186985,-0.009092028,-0.03764422,0.020812681,0.04674532,-0.016736101,0.024479253,0.0049975123,0.037779946,0.050931443,0.022438081,-0.09396736,0.0538742,-0.044172093,-0.03611236,0.037641294,0.06129441,-0.0111941,0.0052451366,0.02697477,-0.0019588335,-0.009764655,-0.0642053,-0.005377331,-0.057245035,-0.035391305,-0.052404605,0.0076741637,-0.010414445,0.019714693,0.05618868,-0.07429701,0.009183815,0.0039664204,-0.026200753,0.07458374,-0.012080793,-0.020872565,0.048616707,-0.00749499,0.006122261,-0.06593062,-0.029560542,0.008270463,-0.0517967,0.0031605263,0.015145205,0.012721624,-0.011647024,0.00090579595,-0.069293745,0.03580083,0.087416865,0.053461637,0.054931838,-0.0068894294,0.0011084247,-0.13116288,0.03392188,0.08126661,-3.2740427e-08,-0.013497613,-0.11153368,0.07262968,-0.018207606,0.018745298,0.050772958,-0.024058128,0.022234248,0.10195038,0.011434331,-0.016915044,0.077503905,-0.031816628,0.0036391523,-0.020111151,-0.0023749913,0.08470969,0.04134659,0.00079592713,0.036855128,-0.037513316,-0.008755826,0.013690128,0.0032883584,0.01834165,-0.115371786,-0.0058690766,0.016689302,-0.036949407,-0.068161905,-0.074532494,0.030604782,-0.029787505,-0.056745403,-0.10446204,0.026621252,-0.060551487,0.038215436,-0.002328688,0.040826857,0.02517282,-0.09665408,-0.0050232224,-0.04096009,-0.0140680475,0.012528746,-0.026593985,-0.011260919,0.014897216,-0.075066976,0.0073657273,-0.0028788743,0.041388873,-0.09234205,-0.07955307,-0.006732224,-0.017771496,-0.07285297,-0.025139263,-0.07112466,0.0768991,0.05677761,0.16806616,-0.048459377 +6.3.2.58,"Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.",384,1.0,-0.09852088,-0.08168057,-0.10810335,-0.0064471914,0.040991347,-0.04783617,-0.045182794,0.031152602,0.038227588,-0.01614853,0.028829293,-0.027475702,-0.040244717,0.044580653,-0.08442149,-0.017575003,-0.08601417,-0.015831744,0.049133234,-0.015403602,0.014070141,0.081031434,-0.04599835,-0.01488883,-0.01486123,0.022673255,0.07378725,-0.04444952,0.02761624,-0.005726215,-0.015820198,-0.02844227,-0.0059679965,-0.079025455,0.07667049,0.08815832,-0.041875444,-0.0126815345,-0.008904223,-0.034164403,0.031300552,-0.016413433,0.088752195,-0.029812539,-0.015526789,-0.014496563,0.02253644,0.029428674,0.025115553,-0.017046733,-0.005748305,-0.05733102,-0.07367938,0.0023848838,0.043545403,-0.020338265,-0.1506358,-0.03936633,-0.0068297186,0.031226456,0.03026059,0.029029237,0.025453247,-0.03511729,0.07649887,0.014984947,0.055820916,-0.055905655,0.0031459068,-0.022554496,-0.046272576,-0.078149006,-0.045859206,0.023400586,-0.02680929,0.0476618,0.049859688,-0.018480122,-0.0080655,-0.03008661,0.020830931,0.054386675,0.083357945,0.11738727,0.063533455,0.04533742,0.01801896,0.047380608,0.021634076,0.050732248,0.023672255,0.0020644185,0.019886672,-0.028062878,-0.0367923,-0.0013752815,-0.12365998,0.031214006,-0.009902078,0.01809629,-0.03433192,0.06930029,0.005210242,-0.03236805,-0.030211411,0.006659845,-0.01906853,0.06153066,0.050792594,0.052767243,0.07371265,0.0862164,-0.042601947,0.0058157286,0.04380892,0.0687461,-0.0011047557,-0.07808781,-0.012811445,-0.020353569,-0.009277612,0.0006314963,-0.022000292,0.054597303,-0.07492752,0.03725839,-0.10008135,3.029038e-33,-0.031780276,0.022433568,0.065689474,-0.012599322,-0.028329859,0.002186535,-0.09656415,0.0030860112,-0.0021679727,-0.04875422,-0.06988166,-0.056762397,0.008549266,-0.010108969,0.06601979,-0.063041344,0.0125970105,0.058710646,0.061023403,-0.017623136,-0.032005172,0.116344124,-0.03638024,-0.010512857,0.05037803,0.1041193,-0.011298316,-0.063462816,0.10807966,-0.0405352,0.042779785,-0.08873686,-0.042755235,-0.025870996,0.0968603,0.013994523,0.013562653,-0.0315905,0.011640611,0.05905131,-0.053945847,0.027483158,-0.03639802,0.01204799,0.057571735,-0.06142277,-0.016138103,0.0630674,-0.018557116,-0.01394852,0.026647693,0.015509615,0.03318327,-0.01435078,-0.073911585,0.035406817,-0.016426962,-0.0077369683,0.04551734,0.033201884,0.01502553,-0.024735648,-0.024249904,0.010036298,-0.010207154,0.041140232,-0.03912248,-0.1298714,0.050795063,0.046487227,-0.043594133,-0.0018096239,0.04833073,0.058082893,-0.006507613,-0.059100345,-0.06279935,0.038101602,0.092576616,0.057732876,-0.009334458,0.057830293,-0.032986995,-0.06238095,-0.030850813,-0.05911191,-0.087256804,-0.044646665,-0.0019100903,0.01605092,0.029971655,-0.060921196,-0.09172202,0.030024728,0.00013819944,-4.928154e-33,0.02187847,-0.13779014,-0.0034340534,-0.1016507,-0.07852992,0.073952,0.054660417,-0.060926996,-0.0009911886,0.0019877295,0.09917674,0.0028858883,-0.0251387,-0.056200065,-0.004949055,-0.078803055,-0.065033756,0.06734433,0.015113346,-0.028674403,0.03432651,0.11466127,0.09383262,0.017090807,0.013692715,0.06937548,-0.03632459,0.106174,0.05574816,0.04789986,-0.009208229,0.025964238,-0.055312525,-0.041537426,-0.05806344,0.07600805,-0.026827052,0.01993569,-0.007334291,-0.020845499,0.05026257,0.0702591,0.041711494,0.0996142,-0.0049221586,0.08437619,-0.080092624,0.11065611,0.009625899,-0.09243894,0.03252406,0.050545935,-0.039424647,-0.0042650793,0.016749771,0.01690038,0.022743635,-0.02976581,-0.025771588,-0.004319638,-0.04637749,-0.097570464,0.031756245,-0.021539431,0.03901346,-0.0013862014,0.025084486,0.031650495,0.056882337,-0.032119557,0.06916907,0.0073236926,0.04860899,-0.0046611386,-0.039347585,-0.056431215,0.015333692,-0.0745703,0.0770453,-0.12979028,-0.040757697,0.014900403,0.03663954,0.0070556467,0.0030526093,-0.078198984,0.08252679,0.09310192,0.042976234,0.0068985606,-0.010512872,-0.0007459952,-0.042422406,0.054853693,-0.057570096,-4.133698e-08,0.023377286,-0.082030915,0.036995865,-0.076538816,-0.01791199,0.058328822,-0.062156186,-0.06265506,0.042827085,-0.0109432535,-0.015686745,-0.0066455514,-0.05037618,-0.043659307,-0.009510543,0.026173493,0.006251373,-0.0067844386,-0.032938883,-0.07349118,-0.06316154,-0.0017964873,-0.121747054,0.015454356,-0.021180306,-0.039983865,-0.0008140705,0.078068495,-0.050308753,0.058899574,-0.025773814,0.024045778,-0.0064223227,-0.008063624,-0.030544182,0.021886932,0.009554139,-0.02473911,-0.026397757,-0.047067653,-0.056713235,-0.0051776646,-0.009810766,0.010833601,0.0074743135,0.01950888,0.026806146,0.009506236,-0.014248241,0.07479514,0.009257444,-0.059521873,0.020820009,-0.027621562,-0.110367276,-0.016155472,0.035325304,-0.13044173,-0.020622436,-0.008884822,0.040463332,0.014308769,0.15510266,0.07552717 +7.2.2.20,"ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high-affinity import of Zn2+.",384,0.99999994,-0.1112836,-0.055194594,-0.0057686646,-0.005266418,-0.056789145,-0.016316282,0.070439644,0.11173638,0.047391035,-0.090818726,0.023967879,-0.049196593,-0.00013437081,0.13296801,-0.040103264,-0.03520968,-0.063932724,0.0067590224,0.030015849,-0.0057047657,0.01748537,0.11252547,-0.018819818,0.027346376,-0.086925484,-0.009874351,0.01049212,0.0058296076,0.010185618,-0.0061190138,-0.050276842,0.023754796,0.009207142,0.030920617,0.018235987,0.03800413,-0.001824056,-0.020999152,0.07160576,-0.0017375139,0.13149466,0.036856737,0.107786626,0.046476617,-0.09913765,-0.0014512135,0.07408093,0.0048315264,-0.0194498,-0.0021701606,-0.029375462,-0.037252482,-0.04592032,0.072090775,0.028789427,0.06963887,-0.06622024,0.0048006754,-0.00836478,-0.033607494,0.020567762,0.021201603,0.08910703,0.07127157,0.04273008,-0.037368592,-0.067801975,0.013582565,-0.0149922995,-0.027860733,-0.0817783,-0.053240746,-0.038364157,0.046294644,0.020543916,-0.02933131,0.0069929822,-0.012405202,-0.061129875,-0.04070388,0.0021221265,-0.035356566,-0.0026061374,0.058812536,0.027337182,-0.020841619,0.005851625,0.036010202,-0.010970161,0.04825256,-0.022602042,-0.019282307,0.07551089,-0.031873595,-0.11627301,-0.027893579,0.0008047882,0.03449826,0.026219185,0.025613733,0.057976857,0.04911191,0.0872091,-0.028734175,0.017015118,-0.02913002,0.040422913,0.03404271,-0.016754046,0.012163523,0.0007488334,0.013735511,-0.0031837306,-0.095088065,-0.034595612,0.076845944,-0.025414169,0.030357897,-0.032769013,0.0076981573,-0.061667643,-0.102643006,-0.018484026,-0.056862995,-0.011671852,0.04837164,-0.113669656,-1.432807e-33,-0.11935456,-0.035242636,0.0027255877,0.012247474,-0.0052904678,-0.026833445,0.00016315856,-0.031554677,-0.008714136,-0.08548475,-0.05045412,-0.016075628,0.0052368594,0.11856531,-0.034155987,-0.035449937,-0.09486894,0.035891093,0.07068951,0.016079912,0.08282593,0.037830926,0.00034367337,-0.070877634,0.12731643,0.0023856587,-0.012167693,-0.03678455,0.057161715,-0.03364095,0.028496763,-0.04878869,-0.11657358,-0.026478104,0.090182826,-0.056249727,-0.01782898,-0.0118611865,0.039930478,-0.06752919,-0.07199382,-0.028657533,-0.07408081,0.07810198,0.06642704,-0.022474447,-0.04065878,0.06861606,-0.03680243,-0.018916696,0.069962114,-0.14413843,0.050342333,-0.04563591,-0.01126743,-0.0046879184,-0.024225289,0.051103063,-0.03744438,0.04660253,0.08438123,0.099071205,-0.054266732,0.040320214,0.02956192,0.047915835,-0.05139319,-0.12236939,0.0587283,0.08644244,-0.0066128867,0.010184643,0.059380498,0.049607154,0.057117738,-0.007442448,-0.089994304,-0.042946596,0.06089655,0.038343005,-0.073045366,-0.09280565,0.046318702,0.0031574825,-0.09010922,-0.06218778,-0.016243434,-0.029022966,0.02044039,-0.031835314,0.11298147,0.01160687,-0.069460094,0.07594491,0.012464254,1.7948911e-34,0.053902064,-0.00796054,0.07852296,-0.05080506,-0.046334766,-0.012146633,-0.0021887235,-0.020627363,0.008120351,-0.034328647,0.040303938,0.06458641,0.027415581,-0.010990691,0.029661806,-0.07326597,-0.08128924,0.019717833,-0.0019874433,-0.036555782,0.019967856,-0.029776156,0.014816502,0.0062540313,-0.06912041,0.020268999,-0.0043813754,0.09116176,0.02932801,0.05072521,-0.08227674,0.030540176,0.0017230463,-0.093764104,-0.07537447,0.04445238,0.009743028,0.020653551,-0.041490667,-0.06519216,0.019010717,0.019193532,-0.03132775,0.074630596,-0.011125199,0.09629342,0.020815808,0.012925003,0.02443628,-0.008450514,-0.0060785264,-0.011870859,-0.022487352,-0.0048547396,0.053262915,0.079616986,-0.012518952,-0.012919575,0.042594258,-0.08410808,-0.036481597,-0.089343846,0.09186276,-0.0068991547,-0.0051255673,-0.0373731,0.044258345,-0.043878123,-0.04338291,0.051343434,0.10844555,0.051118493,0.009961776,0.0125077935,-0.01573247,0.035242014,-0.03209917,-0.05464774,-0.040862285,0.0076290956,-0.048128705,0.03220243,-0.026203398,0.035462454,0.09390702,0.024682034,0.009365028,0.025018673,-0.005986694,0.022245811,0.021651989,0.016929073,-0.0042101685,0.042330727,-0.10385709,-3.2408046e-08,-0.009752453,-0.078906335,0.0050018253,-0.0783305,-0.004720223,0.03354559,-0.08763426,0.027859295,0.076407276,0.049388856,0.00636755,0.10483548,-0.009185794,0.03799209,0.07941175,0.07064978,-0.038080648,-0.0185424,-0.010775445,-0.03830503,-0.025109136,-0.008601311,-0.02734906,0.057608888,0.076740146,-0.065204285,-0.02425689,0.06950615,-0.005210814,-0.08279257,0.041297697,0.018845238,0.023416836,0.0027422286,-0.047790658,0.04440277,-0.045230918,-0.05118511,-0.060343347,0.033376984,0.029629372,-0.02982968,-0.045342386,-0.0067469557,0.06911721,0.012993362,-0.037452884,0.07320517,-0.025695419,-0.007253564,0.026407074,-0.012568324,-0.012480553,-0.027824184,-0.05790192,-0.003139611,-0.052777257,-0.0027598843,-0.008202068,0.040662225,0.016150767,0.029760443,0.11628818,-0.009634086 +7.6.2.14,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli K-12 interacts with an extracytoplasmic substrate binding protein and imports a broad range of aliphatic sulfonates for use as a source of sulfur.",384,0.99999994,-0.080488525,-0.049474206,-0.07752153,-0.041740105,-0.11514504,0.03884651,0.059429284,0.049437296,0.07495878,-0.07412577,0.04756659,-0.009333351,-0.038125742,0.07151664,-0.019070724,-0.027239738,-0.043861978,0.061371792,0.010076554,-0.05704504,0.024792386,0.027460419,-0.05827355,0.00018435213,-0.074990794,0.0906253,-0.004255624,-0.010118511,-0.04874342,-0.043321736,-0.08243014,0.0002513265,-0.007528863,-0.029354898,0.005302602,0.09762537,-0.030058993,-0.025030231,0.05305555,-0.036936667,0.08654686,0.015563467,0.046962336,0.05348592,-0.11478261,-0.045850713,0.013417273,0.058039352,0.023598984,-0.098714575,-0.008352666,-0.010935623,-0.06207846,0.08881217,0.029578486,0.058318086,-0.08007989,-0.00076472305,0.013579771,-0.06701059,-0.027194,0.019023709,0.094959036,0.051946,-0.009523304,-0.06038775,-0.006311015,0.032161575,0.018326268,0.001716325,-0.10666126,-0.05900662,-0.03784898,0.06554342,0.022350352,0.0065091434,-0.0068688053,-0.006766121,0.009814573,-0.028498707,0.013259119,-0.019566853,-0.03678938,0.07012172,0.020564556,-0.066146076,0.02542763,-0.008077427,0.009532112,0.028977128,0.006932899,-0.076221295,0.04094798,-0.05516004,-0.10001249,-0.0073328493,-0.015982302,0.09022341,0.0038253085,-0.00752343,0.055818655,0.07403703,0.01125976,-0.0453971,0.0013483572,-0.018400352,-0.012039183,0.042364568,-0.02253846,0.002765413,-0.04573018,-0.013190833,-0.01145444,-0.07774219,0.0016528192,0.08097774,0.014316257,-0.008526461,-0.06103821,0.013444765,-0.09410651,-0.08613929,-0.029485188,-0.020964166,0.0046387664,-0.012437136,-0.12566589,-1.0207045e-34,0.0011497986,-0.032008074,0.0899405,-0.017516986,-0.013545105,-0.07334007,-0.015132084,0.000250207,-0.006279383,-0.04311265,-0.035345014,-0.028573783,0.02327103,0.05163584,-0.051215354,0.016124861,-0.11509291,0.05007979,0.08205235,-0.027518611,0.02985418,0.0064557316,0.027581954,-0.083381355,0.065534666,0.025479978,-0.036406264,0.004457271,0.041450944,0.003481019,0.058938425,-0.04843356,-0.09834337,0.054282933,0.057261366,-0.062765405,-0.033283938,-0.009566645,0.045417957,-0.059166383,-0.059210572,-0.025145097,-0.028279565,0.07054301,0.023096265,-0.026378687,-0.029003255,0.05339543,0.03365388,0.03750607,0.03146771,-0.13733889,0.0936119,-0.049302317,0.0138581265,0.031802543,-0.00037697644,0.02043817,-0.033716746,0.05159395,0.038905315,0.12315266,-0.06373531,0.016794944,0.05338579,0.07349666,-0.096774794,-0.06842807,0.005551196,0.082971856,-0.022587676,0.022148222,0.013276748,0.059005283,0.04967852,0.031596694,-0.06845487,-0.03904762,0.006099388,0.08712797,-0.011523464,-0.124708414,-0.0053148353,-0.0023242864,-0.13795707,-0.03313484,-0.025461927,-0.01177765,0.03167072,0.020914435,0.06880619,0.021789296,-0.08163422,0.086905226,0.029459473,-2.7745065e-33,0.09742094,-0.016726552,0.07891759,-0.07846643,-0.0673711,0.022218654,0.05085482,-0.0033925534,0.018469913,0.012336008,0.022490995,0.08196691,0.038387723,-0.030433066,0.010069759,-0.017334105,-0.016226944,-0.019362492,-0.020868322,-0.030930182,-0.007291429,0.021324016,-0.03199819,0.046207078,-0.068005495,-0.0017615097,0.026828827,0.035854015,-0.0015544866,0.050245915,-0.0022008617,-0.014320994,0.007840853,-0.07357001,-0.073679656,0.011571044,-0.0041308654,0.026730817,-0.03148741,-0.027595576,0.0038574692,0.029568858,0.019113729,0.078111365,0.022646783,0.05349401,0.016996074,0.042058986,0.042457223,-0.030019792,0.027591024,-0.022009239,-0.021878473,0.021667847,0.04967001,0.074226744,-0.05189809,-0.009838296,0.040264796,-0.060559176,-0.045473985,-0.10646417,0.058618106,-0.07615516,-0.019989882,-0.019721562,0.0028472766,-0.11395702,-0.043149136,0.034462214,0.051708385,-0.002461872,-0.017453674,-0.023498002,-0.00091185555,0.011245472,-0.017083565,0.0008485851,-0.074938715,0.037965722,-0.04169375,0.040130723,-0.057654385,-0.024608852,0.12757835,-0.0034328066,-0.019223329,0.04593909,0.0017520188,0.04645344,0.019470546,0.012419238,-0.016731642,0.078575045,-0.069110535,-3.506258e-08,-0.029943855,-0.04598562,0.023714019,-0.021084724,-0.012190636,0.095132954,-0.04542579,0.0077216905,0.074870385,0.053945642,0.045005627,0.13654055,0.024100637,0.046894323,0.068720356,0.03099881,-0.05127728,-0.021309972,0.009541337,-0.09185401,-0.01181672,-0.075334325,-0.026821163,0.05750834,0.10604423,-0.052561622,0.041345093,-0.0011018601,-0.039823107,-0.053432886,0.060962435,0.031679645,-0.022412593,-0.010218031,-0.0027605968,0.06262417,-0.05396113,-0.027087579,-0.04650665,0.05895984,0.047779012,-0.0039146645,-0.12005946,0.029816777,0.04352167,0.06799632,-0.03466161,0.08751808,-0.117165945,0.01401792,0.061890915,0.00010745239,-0.00018783007,-0.047601808,-0.055963427,0.027912842,-0.0011299092,-0.06612724,0.008612221,0.056219343,0.0436856,-0.026933996,0.11342729,0.013025232 +7.6.2.15,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, characterized from the bacterium Salmonella typhimurium, is a heterodimeric complex that interacts with an extracytoplasmic substrate binding protein and functions to import thiamine, thiamine monophosphate and thiamine diphosphate.",384,1.0,-0.05511759,-0.037230838,-0.048597082,-0.043770205,-0.0928964,0.0060574,0.062092867,0.071402684,0.06540113,-0.08306204,0.018667322,-0.060157295,-0.01923948,0.11002569,0.011831253,-0.06371377,-0.052999854,-0.005916131,0.016795902,-0.054955587,0.0039654817,0.11902333,-0.025238343,-0.0018184839,-0.10208993,0.057994686,0.01456006,-0.01206901,-0.015596166,-0.036541816,-0.13226219,-0.006918333,0.04455604,-0.010356323,-0.010131603,0.09820507,-0.025390001,0.0045532845,0.0891964,0.022099243,0.14491265,0.00728439,0.08237467,0.063583866,-0.1585949,-0.017344289,0.05494678,0.038308393,0.006733125,0.024022022,-0.028179383,-0.0113019645,-0.021218495,0.018456077,0.009674647,0.043598637,-0.0040663136,-0.008344989,-0.015776131,-0.06257848,0.035528578,-0.00909595,0.084708154,0.06140811,0.04880459,-0.043674026,-0.025314355,0.018112173,0.015522286,-0.054856583,-0.07499408,-0.04956354,-0.050456703,0.06564338,0.014955307,-0.0010910914,-0.007388897,-0.005463128,0.015290457,-0.024997128,-0.008353639,-0.02416722,-0.002981804,0.05269429,0.034150075,-0.0027238973,0.010833515,0.026147364,0.019358885,0.016028626,0.004879359,-0.05994318,0.034527063,-0.049385462,-0.11514664,-0.004990051,-0.015710127,0.0027500507,0.0061973953,-0.0028884588,0.06444983,0.036324427,0.029285094,-0.027058125,0.0008202837,-0.0196715,-0.012569376,0.04194356,-0.028845305,-0.010083768,-0.026577571,0.018513715,0.052319832,-0.052818134,-0.029553406,0.0572101,-0.038017448,0.014407843,-0.012329569,0.010383973,-0.046217818,-0.103863195,0.029243054,-0.017130984,0.0109237805,0.01551275,-0.08081829,2.1439496e-33,-0.07134729,-0.027661992,0.039030474,-0.009592372,0.016502665,-0.048341732,0.018116804,-0.026002523,-0.029549226,-0.03983522,-0.006631769,-0.013724108,-0.0008122241,0.09237147,-0.025312636,-0.008734316,-0.08734591,0.078327134,0.07123276,-0.008988392,0.06621867,0.08010752,0.028159969,-0.0501626,0.06656828,0.031925805,-0.044864032,0.02495658,0.06839868,-0.01592321,0.051882356,-0.032369282,-0.11888064,-0.032500386,0.07144629,-0.059532247,-0.02997075,0.00780908,0.011229826,-0.040523354,-0.09859365,-0.026948113,-0.06983722,0.07138549,0.034460917,-0.07662296,-0.022490893,0.04676849,-0.030360704,0.013749753,0.040699583,-0.13485347,0.10001633,-0.10392662,0.0035459995,-0.02404391,0.012334448,0.059111185,-0.027213428,0.06510635,0.060101394,0.10798375,-0.061213862,0.048441786,0.02605383,0.041979574,-0.06207469,-0.109032534,0.04317574,0.108256765,0.05178845,0.040696893,0.031246314,0.040861204,0.01883278,0.019382913,-0.09461695,-0.082957864,-0.012273291,0.018440176,-0.04213866,-0.06296571,0.0617767,-0.034883406,-0.11839622,-0.035543725,0.00933151,-0.023708977,0.01690726,-0.022212353,0.12361717,0.073459275,-0.081920706,0.05862093,0.043685805,-3.3906323e-33,0.07912893,-0.022624081,0.07727197,-0.09267163,-0.08253589,-0.014166988,0.013881639,0.018269787,0.02516355,-0.020588534,0.036743075,0.061112903,-0.02911649,-0.03565392,0.018254166,-0.062739246,-0.013211134,0.008337519,-0.0504386,-0.06844769,-0.033930648,-0.015621539,-0.0013326902,0.03047142,-0.09591808,0.0074939737,-0.025801389,0.06598925,-0.0055957814,0.040537234,-0.047821112,0.03650515,0.010127653,-0.03439166,-0.05631698,0.019146923,0.012586361,0.038217265,0.013462951,-0.021870254,0.01001886,0.056582104,0.013626101,0.053913984,0.0012676594,0.10405127,-0.0092286,0.03814451,0.0051417723,-0.021467872,-0.0025277426,-0.023000875,0.011347596,-0.021887282,0.060166698,0.09119488,-0.04063242,-0.054127134,0.046108715,-0.09126194,-0.047656536,-0.091901645,0.07161927,-0.01638954,0.0015268521,-0.029172497,0.013973377,-0.04498637,-0.018423513,0.073844075,0.06564717,0.06017253,0.002614266,-0.00786567,0.0031836377,-0.010879519,0.0064952113,-0.016687024,-0.03994969,-0.00974066,0.005469846,0.032761052,-0.062912725,-0.024995543,0.08098265,0.033380955,0.0063679614,0.042043176,-0.0017587699,0.059574194,-0.0041229897,0.019141052,-0.016719028,0.07845262,-0.020255685,-3.9944965e-08,0.010653977,-0.066770144,-0.015428683,-0.07337653,-0.04470253,0.055980824,-0.0680146,-0.0036083336,0.13907139,0.048979934,0.010845903,0.0935854,0.009324412,0.027953476,0.051154308,0.0469794,-0.032513995,-0.018705321,-0.010019453,-0.081350036,-0.010235772,-0.05307808,-0.031610798,0.056693118,0.073200814,-0.04294634,0.005925105,0.033161342,-0.0219931,-0.05625568,0.0043588574,0.024679901,-0.045546275,0.02643365,-0.012742713,0.04532435,-0.05008801,-0.016027818,-0.0681374,0.06070489,0.04651242,-0.037893783,-0.12989444,0.0049252217,0.0584215,0.035478365,-0.053952977,0.0653988,-0.06388807,-0.04681729,-0.0030511708,0.022932911,-0.0024381336,-0.009580238,-0.08893491,0.03715802,-0.066787235,-0.022572562,-0.060616,0.030916546,0.052958015,0.025132937,0.13908665,-0.056654785 +7.6.2.16,"ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of putrescine. Differs in specificity from EC 7.6.2.11, ABC-type polyamine transporter.",384,0.99999994,-0.06789559,-0.09957778,-0.02310188,-0.08442311,-0.08225034,0.040182758,0.0415813,0.09820022,0.068662494,-0.044057988,0.028201263,-0.008895486,0.020973695,0.12535056,-0.0012486739,-0.0318652,-0.04014121,0.013569856,0.031328663,-0.030964546,0.025446108,0.101172686,-0.04905694,0.0038304087,-0.09958966,0.03867729,0.0072033536,-0.02609357,-0.01599567,-0.005925547,-0.13308668,-0.0130385235,-0.025769772,-0.019502139,-0.001122053,0.10127806,-0.020297505,0.00019023806,0.064000115,0.014175754,0.09221687,-0.017921016,0.08393046,0.043445047,-0.13687354,-0.056709714,0.09717484,0.0072435504,0.03216265,-0.021601968,0.014343117,-0.010150177,-0.02215192,0.02743136,0.02258792,0.03830314,-0.037694383,0.02303956,-0.038914286,-0.040109176,-0.013960466,0.014009094,0.097389504,0.06539212,0.033165433,-0.049937982,-0.011649944,0.024984391,-0.031312674,-0.034388382,-0.05498809,-0.058445096,-0.008250289,0.04457061,0.009904169,-0.03885615,-0.021581646,0.04542071,-0.02461388,-0.0056252964,-0.01144279,-0.065114565,-0.06068178,0.06661366,-0.0075938855,0.014445973,0.017920915,0.04706561,-0.0017787585,0.006944803,-0.028692199,-0.042746026,0.010195303,-0.05480671,-0.09040825,-0.041645505,-0.036924273,0.049520176,0.013963889,-0.0221838,0.049983192,0.085728124,0.04727687,0.01321093,0.0008300468,-0.06306034,0.028314954,0.052894685,-0.018624527,0.0060757273,-0.0052085,0.037855122,0.019279324,-0.009061677,-0.03672342,0.09270905,-2.3135783e-05,-0.022657637,-0.04082075,-0.03596426,-0.057717226,-0.07916914,0.023307726,0.013359612,-0.0062986766,-0.024674393,-0.08372448,-2.1898796e-34,-0.08715196,-0.050190393,0.06772868,-0.03268599,9.6153955e-05,-0.012626587,-0.018899905,0.017265957,0.0030654406,-0.073952585,-0.0483018,-0.034658942,0.04841841,0.08654779,-0.0049516065,-0.03610892,-0.099120215,0.042961266,0.096036315,-0.044986505,0.09282182,0.05973923,0.021840539,-0.015084082,0.06400725,-0.018465733,0.0036310854,-0.02975657,0.05345189,-0.03502899,0.014870381,-0.042925254,-0.10135269,-0.035044122,0.04386869,-0.056539446,-0.033740997,0.0138061205,0.047649376,-0.010779384,-0.010701125,-0.03483177,-0.07084058,0.083414644,0.059276495,-0.054907806,-0.038164698,0.06693009,-0.06335776,0.05668897,0.040477905,-0.15204212,0.062542826,-0.03022741,-0.06388201,-0.041619185,-0.026410708,0.027089197,-0.0823627,0.07369133,0.08150648,0.08688817,-0.02478709,0.0110214185,0.05580172,0.015036206,-0.079084516,-0.09045985,0.02778691,0.108742215,-0.004515622,0.032245718,0.0165473,0.033991158,0.03764735,-0.0047208923,-0.15860626,-0.008603137,0.039022148,0.049708337,-0.025037352,-0.060274307,0.0061306143,0.0005108797,-0.10811448,-0.009308364,0.047308177,-0.046967596,0.024193788,-0.020823043,0.14732613,-0.021692727,-0.063738614,0.075052634,0.03256644,-1.4058501e-33,0.0558663,-0.04950986,0.11519281,-0.038896326,-0.0121197505,-0.017279372,0.033986345,0.035791714,0.023566438,-0.054578103,0.0058632363,0.06315722,0.00017144828,-0.021676041,0.025511986,-0.06215051,-0.09137503,0.0044556335,-0.03233188,-0.032316674,-0.021198332,-0.055924803,0.0061665205,0.015206728,-0.056946754,0.0328533,0.0017497205,0.057999186,-0.025042377,0.040276904,-0.029544663,0.018278496,-0.027621947,0.00787969,-0.06620279,0.043292485,-0.010004946,0.045708966,-0.013764517,-0.029691726,0.0006342433,0.06793702,-0.025156535,0.07142861,-0.011960583,0.09237177,-0.024814758,0.03897951,0.012273691,-0.035278615,-0.0039171292,-0.039999787,0.008633803,-0.027688121,0.06727565,0.07980931,-0.030778872,-0.038279142,0.03873736,-0.07713546,-0.030339997,-0.037706196,0.039148834,0.004338112,-0.0031277013,-0.08848701,0.045306776,-0.038565367,-0.053118207,0.040997434,0.06311451,-0.016768105,0.016426068,0.040788103,0.04853715,-0.0046220655,-0.003328892,-0.056572784,-0.03992145,0.0028236161,-0.07224196,0.025641305,-0.05285582,0.010849268,0.12546612,0.057441294,0.044111922,0.029677648,-0.005968888,0.017370192,0.019965688,0.045531977,0.0032114743,0.086957164,-0.02358375,-3.7601843e-08,0.051419877,-0.08668804,-0.020577768,-0.04812748,-0.02494226,0.06665904,-0.046991453,0.023522414,0.11127639,0.03467882,0.004810604,0.07255905,-0.010639868,0.03033665,0.059044074,0.04627997,-0.021362018,-0.0038972567,-0.006703505,-0.09449406,-0.074814335,-0.0661629,-0.03479633,0.024218319,0.07388802,-0.03082998,-0.02010115,0.086205,-0.026323546,-0.05778596,0.037586093,-0.008160321,-0.013489849,-0.01457699,0.006881241,0.060334377,0.0007782138,0.014232829,-0.013533329,0.07304074,0.035759807,-0.06355139,-0.06479471,0.012226573,0.11472565,0.031982176,-0.06915968,0.08552913,-0.04361691,-0.01850433,0.024692627,0.0101837935,0.017926043,-0.039383363,-0.06767906,-0.00679211,-0.12895042,-0.033887267,-0.00068655174,0.057001267,-0.0034539204,0.04512914,0.103290014,-0.008298606 +1.1.1.419,"The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. It also catalyses the activity of EC 5.5.1.34, (+)-cis,trans-nepetalactol synthase.",384,1.0,-0.082526326,0.02120623,-0.07718878,0.006322433,0.043025393,0.06526738,-0.09736738,0.018841801,0.067081444,-0.0032522308,0.052721746,-0.11643778,-0.06260729,0.018508527,-0.057643786,0.027485978,-0.04839889,0.040046077,0.0030302666,-0.11072587,0.0567649,0.022755709,-0.0010810369,-0.01155585,-0.017018024,0.0046114568,-0.079303384,-0.01833023,0.03887708,-0.0811849,-0.06973353,0.010010315,-0.031553574,-0.04356789,-0.012970736,0.017136976,-0.06597137,-0.07919533,0.05087003,0.09036168,0.106819525,-0.008978585,-0.083718814,-0.018778259,-0.016036227,-0.06755019,-0.026236717,0.009209489,0.051142443,-0.032320883,-0.056321852,-0.017573759,-0.042887382,-0.029327448,-0.012309671,-0.0004806718,0.038891852,-0.024320671,0.03629031,0.02184652,0.10271142,-0.021874117,0.024794376,-0.011862201,0.035317626,-0.04314837,0.0015286166,-0.008173202,0.016034082,-0.0069416766,-0.13748446,-0.061837476,-0.024945442,0.02428568,-0.012692878,0.08190006,-0.080315836,-0.0070095076,0.043214347,0.007011657,0.043000348,0.060070846,-0.028232662,0.014518988,0.10017788,0.043961175,0.048451245,0.016684737,0.00029275997,0.0020943189,-0.009143886,-0.058496524,-0.0004915136,0.010816071,-0.049018342,0.063795514,-0.013729325,0.028785383,-0.024137598,-0.046089835,0.009464172,0.07074395,-0.07643413,-0.053976327,-0.09104179,-0.00014163768,-0.024204975,0.07180067,0.022243276,0.034632504,-0.07263023,-0.0933485,0.013867709,-0.040302955,0.0057491246,0.13692713,-0.027219234,0.002867714,-0.017856348,-0.041444775,0.057449885,-0.04698245,-0.047461107,0.043425687,-0.014933312,0.04729455,-0.115352616,-5.018132e-34,0.1125493,0.031289678,-0.019749992,0.057494782,0.034105472,0.036035508,-0.09018799,0.07391069,-0.1111574,-0.05639292,-0.012086048,0.014910342,0.029010938,0.015348376,-0.055422664,-0.011803678,0.03228555,-0.07157021,0.020280436,-0.009575462,0.056647066,0.041287832,-0.038812835,0.0071488386,0.007096975,0.031578492,-0.098600425,-0.012420513,-0.004426256,-0.03359809,-0.055182442,-0.09934839,-0.0742886,0.04744875,0.05083313,-0.057798244,0.03060791,-0.04334756,-0.039641757,0.03853251,-0.025738314,0.056560077,0.028556919,-0.036116097,0.065196574,-0.01542951,-0.038677976,0.06008635,0.08399383,0.07052581,-0.024196727,-0.028033974,0.07870348,-0.026978118,-0.040498625,0.01637027,-0.030474782,0.0038373345,-0.0077112904,0.033458296,-0.038138565,0.024056526,-0.045567576,0.019936424,0.0021567477,0.0868992,-0.12647168,-0.04789487,0.113879405,0.075658545,-0.052987896,0.06306667,0.012568604,0.037496936,0.057534054,-0.02513913,-0.11164165,-0.025569258,-0.043347664,0.078481644,0.0036289343,0.020828193,-0.011791884,-0.020883173,-0.038963947,-0.0056755673,-0.0017601366,0.023075642,0.030961173,0.019790865,0.062729575,-0.053853784,-0.016618062,0.030159548,0.04673694,1.0466684e-34,0.09925577,-0.06867587,0.037985086,-0.070494935,-0.08220695,0.091221996,-0.0039655822,-0.09695797,0.026563242,0.010267954,0.05648369,0.05583361,0.098979935,-0.0032165695,0.025135124,-0.035456404,-0.00059599365,0.06960232,0.01103558,-0.03279797,0.022462498,0.06275652,0.013821582,0.010831336,0.08774565,0.00044069497,0.039293867,0.031397868,-0.004063125,0.0057174778,-0.024556186,-0.056566708,-0.08279975,0.00551993,0.01145697,-0.022803007,-0.030963564,0.015261695,0.00421412,-0.033614554,0.008907672,0.044420574,0.016572496,0.07420944,0.06984267,0.0701116,-0.08749768,0.044997446,0.042631306,-0.02438662,0.0490546,-0.0031444312,-0.03691129,-0.023338528,0.057428945,0.03942527,0.0006832422,0.040780082,0.023791434,0.019265454,0.0047873906,-0.0042421287,-0.030273909,-0.049778584,0.011491041,0.08360723,0.016828934,0.05104838,0.052762046,-0.006073837,0.11110079,0.06944126,0.009144624,-0.008277531,-0.03158964,-0.068335064,-0.037350163,-0.020923477,-0.010507699,-0.020730827,-0.039404124,-0.015634986,-0.038353235,-0.11057856,-0.034638636,0.0395782,0.0044346857,0.08968664,0.07179275,0.06816173,-0.004060939,0.0050365133,-0.07659033,0.03940137,0.04075467,-3.1390716e-08,0.032688215,-0.020407936,0.029193265,-0.05104244,0.0357172,0.049427606,0.051501535,-0.06966744,0.06850638,0.06670252,0.047325242,0.013351777,0.040013272,0.056153353,0.05121162,0.034284767,0.04091571,0.054853324,0.032366637,0.0012705772,-0.026580261,-0.013383924,-0.11258342,0.06266438,0.0077941143,-0.16307312,0.044224832,0.025520839,0.036048517,-0.012754017,0.014977643,-0.010903187,0.06903397,-0.016548127,-0.062949516,-0.0035753285,-0.011584996,-0.015182531,-0.052680504,0.016527507,0.04069723,-0.060131695,-0.037644494,-0.027795251,-0.019059941,0.029124383,0.025744295,-0.080852605,-0.009623554,0.026405914,0.0324984,-0.029358717,0.06558845,-0.02564592,-0.100874566,-0.03136886,0.024236955,-0.05628569,-0.018080963,-0.06345045,-0.023403093,0.009076985,0.18572703,-0.00090874545 +1.1.5.13,"The enzyme, characterized from the bacterium Escherichia coli, contains an FAD cofactor that is not covalently attached. It is bound to the cytoplasmic membrane and is coupled to the membrane quinone pool.",384,1.0,-0.07745144,-0.07114557,-0.0960207,-0.05913212,0.021249263,0.014792941,-0.04724341,0.06255496,0.05253643,-0.022038784,0.026927661,-0.08562125,-0.09025825,0.10521107,-0.022246575,-0.06548504,-0.06988817,-0.04657003,-0.01666963,-0.044110417,0.03498934,0.016422827,-0.052063756,-0.04205101,0.027015705,0.02233896,0.06253195,-0.062766425,-0.014914654,-0.008668686,-0.058784608,0.020533472,-0.034187417,-0.0073418757,0.04219044,0.08391397,0.07475724,-0.06785714,0.071545586,0.0019614766,0.020912653,0.083153024,0.035518546,0.016476247,0.06676793,0.026289789,0.013463768,-0.0008332382,-0.032046046,-0.044329107,-0.012394882,-0.045303416,-0.051706094,0.019748878,-0.0005585712,0.09511203,0.045745593,-0.0854886,-0.019100428,0.032015387,0.01523715,0.0032831526,0.06478853,0.043662205,0.04329537,-0.08641648,-0.011094444,-0.027548114,-0.0009303937,-0.0069437856,-0.02256309,-0.04047377,-0.028718876,-0.013205226,0.042352866,-0.019427711,-0.044637162,-0.026198542,0.06835276,0.017692812,0.012194287,0.0023929842,0.08610708,0.10331146,0.033810433,-0.037597857,0.08355036,-0.035763897,-0.019849299,0.024690809,0.016903345,5.3912983e-05,0.0028927298,-0.0960763,-0.08914581,0.04394423,-0.0050787022,0.012080201,-0.020395895,-0.03496567,-0.024951639,0.041190274,0.029219348,-0.004072254,-0.05556251,-0.054568317,0.022653641,0.13397622,0.007465278,-0.01986246,-0.00394544,0.0114651695,0.09663761,-0.0675994,-0.012315663,0.001775638,0.015050783,-0.053114433,0.06864807,0.009615671,-0.0048267376,-0.026180744,0.021937354,0.098945394,0.037778772,0.022096151,-0.1120654,3.0538363e-34,0.0678763,-0.04752645,0.01482295,-0.05044694,-0.057014786,-0.049867157,-0.06632935,-0.010400237,-0.06428104,-0.026247965,-0.023575565,-0.009450792,0.014264947,0.015055302,-0.020959225,0.039511234,-0.07747243,-0.039996482,0.036003835,-0.03185408,0.046763238,0.10402831,0.0028182354,0.025056,0.05551079,-0.051628046,-0.055587497,0.059345473,0.0045991046,0.0038093282,-0.0004955402,-0.0789324,-0.048475232,0.05763115,0.005660572,0.015511781,-0.046495322,-0.027749138,-0.07811486,0.01468788,0.033928927,0.0333658,0.024134966,-0.023445036,0.08486884,-0.08906389,-0.031554278,0.05667741,-0.027548138,0.03930928,0.028963204,-0.0057621226,0.060360774,-0.00797701,-0.08091098,0.030739931,0.0031571907,0.013197335,0.007145405,0.03375751,-0.006437873,0.06203915,-0.08609295,0.11323698,0.01814547,0.09097806,0.0024939561,-0.08907475,0.050004113,0.13848516,-0.09490668,-0.024792317,0.004301116,0.02299638,0.035904743,-0.09669064,-0.02367262,-0.06775315,0.025848553,0.02744606,0.013360673,-0.06556755,0.044616185,-0.0379726,-0.039427944,-0.045519553,-0.033773426,-0.052302424,0.010876551,0.017254606,0.046551526,-0.06622952,-0.0017272444,0.052234184,0.04731223,-1.9007575e-33,0.06333968,-0.13518816,0.08940432,-0.06468986,-0.071970396,0.10268788,-0.0041594915,-0.05923629,0.057460334,-0.04787909,0.034256402,0.009329255,0.0002389972,0.027786653,0.024750937,0.042877607,-0.04539605,-0.0093664965,0.035893936,0.027378472,-0.034633197,0.031227026,0.08250815,0.017834762,0.04058458,0.021685276,-0.0722,0.011459221,0.018065292,0.0075488337,-0.041359298,-0.032788787,-0.020458303,-0.057682108,-0.13775694,0.005138452,0.0029678806,-0.016014146,-0.005739844,-0.03401932,0.0037740713,0.033032686,-0.0042461143,0.08146088,0.0071680467,0.054532267,-0.08015139,0.022634787,0.019151513,-0.034422547,-0.07138348,-0.019998081,-0.01516102,-0.028333597,0.021886772,0.06353465,0.057034656,0.039449923,-0.006488374,0.021156047,0.022624532,-0.08223826,0.020634701,-0.023279926,0.090885244,0.015217947,-0.018495463,0.07019644,0.022577059,0.0053402386,0.06362893,0.102291085,-0.02425167,0.013982069,0.0013218193,-0.013978481,-0.05944942,-0.011722273,0.039563935,0.049708378,0.048310935,0.075685315,-0.07022543,0.023602884,-0.025925891,-0.064077884,0.035424296,0.09425846,0.019191144,0.018344171,-0.013054988,0.029964732,0.015850851,0.035481416,0.047786355,-3.3764845e-08,0.051178765,-0.03402667,0.027964143,-0.10245248,0.0028710533,0.070022754,0.010375327,-0.066774756,0.030627975,0.020403288,-0.020687852,0.11270121,-0.0807532,0.009065082,0.026686018,0.0143376,-0.083110884,-0.04661971,-0.027408652,0.013538938,-0.01637794,-0.0069791726,-0.10153986,0.053885244,-0.011351816,-0.0562202,0.014816419,0.0065567954,-0.10629989,0.03468578,-0.057150252,-0.0074041835,-0.017594501,0.0027329468,-0.09094249,0.03855276,0.024429135,-0.04152121,-0.08816744,0.03313884,0.07437734,0.035825748,-0.09653809,-0.01931064,0.036000125,0.05465892,0.034405198,-0.040950205,-0.033543885,0.012792833,0.067233205,-0.052172445,0.014592798,-0.024040151,-0.118743464,-0.022297522,-0.0028389986,-0.08130451,-0.020408316,-0.0116646495,0.05204837,0.0051411265,0.21182361,-0.007918194 +2.1.4.3,"The enzyme, characterized from the bacterium Pseudomonas savastanoi pv. phaseolicola, is involved in the biosynthesis of the toxin phaseolotoxin, a modified tripeptide that causes the 'halo blight' disease of beans.",384,1.0,-0.0677787,-0.018572824,-0.09220336,0.073415026,0.061143998,0.09667222,-0.09675548,0.11692351,0.017155986,-0.027135396,0.05177525,-0.060103234,0.04518,-0.008374617,-0.058931287,-0.013986985,-0.035455156,0.02858029,-0.0116386665,-0.009325746,0.031579565,0.10554086,-0.08274943,0.0604244,-0.056600627,0.0867912,0.045532458,-0.055917304,-0.0042578047,-0.04697562,-0.058402475,0.04532151,-0.033909272,-0.03839019,0.015730115,0.062620424,0.02494981,-0.055308577,0.11111573,-0.05720264,0.0032730396,-0.070245385,-0.0075841667,-0.04272342,0.050790727,-0.014084263,-0.009053653,0.01660208,0.07647687,-0.11519768,-0.081969656,-0.010494026,0.014803393,0.026356414,-0.009186481,-0.032522034,-0.011537161,-0.009825719,0.021003645,0.092104375,-0.017594561,-0.012359049,0.04867538,0.020820502,0.040653184,-0.052373577,-0.0054442286,-0.05237265,0.021173999,-0.09802794,0.023021398,-0.052631073,0.008921409,-0.018660195,0.052316863,0.09411898,-0.032543153,0.015283484,0.030818485,-0.01821886,0.02152079,-0.02335988,0.065252565,0.09315693,0.024866534,-0.005118001,0.022521233,0.023294192,0.027697477,0.05597655,0.045295916,-0.006008401,0.0244033,0.015132109,-0.041716345,0.034789484,-0.012565289,-0.07217676,0.014207594,-0.0015172171,-0.048936613,-0.014602006,-0.08653126,-0.03155135,0.032614306,-0.013609606,0.036111977,0.03644839,0.021834623,-0.009645235,0.062976405,0.010977896,-0.015548718,-0.047254734,0.049785987,0.036573384,0.09438696,-0.021357618,-0.06749024,-0.049991637,0.08811075,-0.071740046,-0.010289439,0.03540944,-0.032934703,-0.0050276113,-0.11269773,1.6699666e-33,0.080217525,0.007815775,-0.031126337,-0.0034712674,-0.007827498,-0.014533005,-0.075124174,-0.031898543,-0.016830117,-0.08802106,-0.0016180362,-0.014115928,-0.0064877165,-0.019252397,-0.0006711228,-0.022344517,-0.022008922,-0.008124909,0.060583685,-0.018551068,-0.0069933403,-0.012350714,0.0003317796,0.0051225517,0.02108107,0.06267704,0.039105665,-0.09405856,-0.04581238,0.018764175,0.060721897,-0.05988778,-0.07225102,0.030231085,0.044373944,-0.03866133,0.016062185,-0.033675898,-0.10148713,0.06283191,-0.07759784,0.033155292,-0.07807654,0.007051381,0.09192947,-0.0076297517,0.01573871,0.15662222,-0.0045729866,0.015494346,-0.01120882,-0.0012277712,0.121494055,-0.033555586,0.04691108,0.03711615,0.040941365,-0.0041353987,-0.0060989563,0.02279847,0.041183945,0.039158326,-0.082811296,0.011569173,-0.017503535,-0.019795602,-0.035535127,-0.042033557,0.035162482,-0.0026113961,-0.029590087,0.010097414,0.039239515,0.02146173,-0.060160846,-0.10167966,0.002536653,0.05659276,-0.049033746,-0.05022171,0.024298452,-0.029967878,0.05990327,0.003832443,-0.080653146,0.12498324,0.05811036,-0.024759304,-0.10732795,-0.07687585,0.12947994,0.056523073,0.022096988,0.10872701,-0.024330825,-6.7757956e-34,0.020048892,-0.09084233,-0.012177566,-0.0062652654,-0.01542803,0.027745115,-0.0038304185,-0.04213374,0.09356178,0.010484975,0.050803956,-0.009627595,0.034084994,-0.05362127,-0.013369298,0.013931964,0.0324454,0.03904232,-0.014217543,-0.04410618,-0.04989486,0.102149144,0.006351123,-0.017986197,0.029947992,0.038504574,-0.024576342,0.11652273,-0.049179155,0.08582958,0.058550265,0.05318743,-0.022609023,-0.039677065,-0.029213686,0.046476778,-0.023045685,-0.05111296,0.06643453,-0.01759677,-0.06491583,0.009074232,-0.019863429,-0.034631178,-0.008594671,0.07867487,0.03561626,0.040936142,0.041069698,-0.037685346,0.01562795,-0.035302207,-0.045388274,0.10050881,-0.02729103,-0.038707018,-0.047777735,0.049632326,-0.014574976,0.00648479,0.010569723,-0.048367348,0.01888247,0.036569327,0.036941137,0.05410554,0.02521952,-0.0051851072,0.069455385,-0.03879893,0.08482281,0.029218543,0.03367254,0.058433972,-0.044033103,-0.014229022,-0.05692126,-0.03652763,-0.05649296,0.009714212,-0.03702265,0.017939815,-0.03530708,-0.03738021,-0.0027536766,-0.11297555,0.016697237,0.1398609,-0.010345996,0.03144184,-0.032794595,0.021267705,-0.009838477,0.026437104,0.082286805,-3.494459e-08,0.07082781,-0.028067812,-0.030227426,-0.036453646,0.06402603,-0.017370105,0.024699882,-0.020841775,0.038909208,-0.03179505,-0.09856095,0.031265758,0.020240711,-0.017314943,0.040274084,-0.0039628926,-0.016867328,0.060701635,-0.029298179,0.03846836,-0.0034161827,-0.12091333,-0.033757698,-0.09515383,-0.023214884,-0.048210774,0.076850094,-0.04655767,0.06341094,-0.017988203,-0.073759474,0.02661337,0.049817894,-0.03763002,-0.17213683,0.10311599,-0.021993313,0.040341757,0.005431301,0.014045772,-0.026019538,-0.061581958,-0.08847674,-0.01887468,-0.02091169,0.031558566,-0.031217564,0.06167404,0.0155385705,-0.023655552,0.052873332,0.00695908,0.07147369,0.0013463292,-0.069836766,0.022147205,0.050552603,-0.02006447,0.040124543,-0.059265293,-0.04269105,0.042491414,0.11436162,-0.024226287 +2.3.1.292,"The enzyme, which is a complex of five polyketide synthase proteins, is involved in the synthesis of the lipid core common to phthiocerols and phenolphthiocerols. The first protein, PpsA, can accept either a C18 or C20 long-chain fatty acyl, or a (4-hydroxyphenyl)-C17 or C19 fatty acyl. The substrates must first be adenylated by EC 6.2.1.59, long-chain fatty acid adenylase/transferase FadD26, which also loads them onto PpsA. PpsA then extends them using a malonyl-CoA extender unit. The PpsB protein adds the next malonyl-CoA extender unit. The absence of a dehydratase and an enoyl reductase domains in the PpsA and PpsB modules results in the formation of the diol portion of the phthiocerol moiety. PpsC adds a third malonyl unit (releasing a water molecule due to its dehydratase domain), PpsD adds an (R)-methylmalonyl unit, releasing a water molecule, and PpsE adds a second (R)-methylmalonyl unit, without releasing a water molecule. The incorporation of the methylmalonyl units results in formation of two branched methyl groups in the elongated product. The enzyme does not contain a thioesterase domain [2], and release of the products requires the tesA-encoded type II thioesterase [1].",384,1.0,-0.15610482,-0.08527316,-0.043039683,-0.04467596,0.034540474,0.014413009,-0.030999286,0.040326126,0.048204876,-0.03284128,0.0404957,-0.04422489,-0.09227151,-0.0086867595,0.013133561,0.015825024,-0.07577961,-0.00321882,-0.0011918083,-0.052668817,0.09268849,-0.017038738,-0.054560065,-0.00798415,-0.011912787,0.023165442,0.10862478,0.016073901,-0.009527865,-0.060846023,0.05206267,-0.10961387,0.054284446,-0.05356416,0.022170601,0.13558586,-0.059019063,-0.026550956,-0.024910752,-0.07122216,0.14481063,-0.038815048,-0.004013941,0.012242716,-0.018869942,-0.05551477,-0.0785375,0.042671632,-0.011864662,-0.033803213,0.024721758,-0.10537761,-0.07323233,0.10324291,-0.015817685,0.048161875,-0.063434534,0.028062487,-0.03727596,-0.027968934,-0.019518932,-0.00533764,-0.01750378,-0.012764569,-0.032421358,-0.043415975,0.04413812,-0.019257892,0.018543385,-0.056775056,-0.113291696,0.02267056,0.016271673,0.015437217,0.015871294,0.027786015,-0.057797708,-0.02455116,-0.01806093,-0.051883608,0.02721605,0.023948437,0.052611448,0.084993966,0.085537516,0.016470226,0.048939213,-0.003191311,-0.009377742,-0.013477777,0.07000251,-0.03576356,-0.0069418405,0.017864661,-0.024258163,0.034030683,-0.039324075,-0.067479186,0.05330005,-0.0052328114,0.005013435,0.034229506,-0.019322727,-0.065749146,-0.07761127,0.024004662,-0.042739004,0.063542776,-0.0056997426,0.043972645,-0.05676833,0.04870217,0.03516945,-0.0316395,-0.020297673,0.047636196,-0.11166369,-0.040367924,0.016779194,-0.0839327,-0.07961163,-0.030824693,-0.013780142,0.03312308,-0.014750563,0.016758705,-0.1340048,4.514321e-33,0.045016006,-0.01832826,0.032232445,0.018828282,-0.033485554,0.0067888093,-0.07588563,0.018217608,-0.06107211,-0.004296232,-0.022770554,-0.05962218,-0.0005984842,0.06895601,0.0099033285,-0.022807986,0.023737494,0.1131794,0.07425388,0.013694889,-0.01620357,0.043970577,-0.034989655,-0.006871185,0.093114145,0.08488069,-0.011797878,0.010421954,0.016194792,0.00044117926,-0.07212245,-0.04291926,-0.019306846,0.07449591,0.049210545,-0.014748282,-0.009723743,-0.07509067,0.024160603,0.019309731,0.026443588,-0.029544616,-0.008125212,-0.043162398,0.04228465,-0.02784396,-0.021253645,0.050142206,0.019307239,0.054523334,0.03101619,-0.009052873,0.06544543,0.07484557,-0.118048474,-0.027589962,-0.08894508,-0.042855173,0.023266891,0.04936777,0.04443844,0.1355146,-0.041505218,-0.020532139,0.014246686,0.08577876,-0.11533896,-0.05104816,0.032395493,0.10600037,0.008441636,0.005246281,0.014180214,0.06512788,0.057006974,-0.046279017,-0.016185168,0.08452601,0.00022291506,0.057435125,0.0063082483,0.00064551714,-0.005070371,-0.040220022,-0.06337251,0.0055214493,-0.02917578,-0.04477413,-0.0011672577,0.034630787,0.047791928,-0.08718975,0.008624341,0.064422384,-0.02607676,-5.0413536e-33,0.083795495,-0.08070208,0.03321653,-0.097222604,-0.019926222,0.032278616,0.057394262,-0.03952532,0.11011762,-0.056485623,0.034288127,0.054414347,0.002333438,-0.032116834,0.0044378857,0.06303463,-0.0642803,0.01665543,0.0056679994,-0.034267157,0.05627969,0.04533814,0.033401165,0.090247735,0.056699514,0.00015499182,0.04289809,0.097284995,0.04103854,0.0469907,-0.03794823,-0.038896546,-0.04211801,0.028746374,-0.05408046,-0.011246439,-0.10053914,0.011413191,-0.010215809,0.047890432,0.01360207,-0.018785547,0.022927498,0.01426756,0.042274397,0.034906983,-0.04557663,0.013685292,0.01926334,-0.08159892,0.006701817,0.03556266,0.039239634,0.08827644,0.027964305,0.021418903,0.05568698,0.010243957,-0.020931596,-0.108125,-0.025554158,-0.07450748,0.022036146,0.05861978,0.0023102937,0.047674898,0.06964704,-0.01023866,-0.0019608268,0.028913047,0.0061916625,0.023465388,0.024544105,-0.004012354,-0.02882699,-0.0033903231,-0.051152933,-0.021236582,-0.01412632,0.0017563648,-0.020029077,-0.023383943,-0.014248174,-0.10322841,0.013281096,-0.0031307747,0.07034737,0.05681883,0.03894397,0.06786768,-0.026381195,0.0429052,-0.03690703,0.09558592,0.08143816,-5.052857e-08,0.02649946,-0.07757781,-0.02189495,-0.045748733,0.000172951,-0.018779729,0.027153967,-0.015768593,-0.006600603,-0.030631062,-0.04620205,0.08537177,0.020381767,0.034520287,0.016871363,0.021361738,0.0010106222,0.031438895,-0.019573934,-0.09629722,-0.09802015,-0.025750192,-0.08830402,0.036056988,0.0042169397,-0.013017069,0.049083274,0.025554411,-0.014569309,0.033009615,0.06801964,0.030421155,-0.03506086,-0.026616143,0.060650423,0.07985643,0.0035610055,-0.01253064,-0.042120874,0.097561136,0.047881138,-0.028535917,-0.035777908,0.014211869,0.044521876,0.010922007,-0.034175046,-0.019781858,-0.029037908,0.072793834,0.04898114,0.06307753,-0.0627886,-0.07601329,-0.12129136,0.009042506,-0.06934813,-0.0440406,-0.0805947,-0.0097705005,0.017682498,-0.043456927,0.15159488,-0.025853118 +2.3.1.293,"The enzyme is part of the fatty acid synthase (FAS) II system of mycobacteria, which extends modified products of the FAS I system, eventually forming meromycolic acids that are incorporated into mycolic acids. Meromycolic acids consist of a long chain, typically 50-60 carbons, which is functionalized by different groups.Two 3-oxoacyl-(acyl carrier protein) synthases function within the FAS II system, encoded by the kasA and kasB genes. The two enzymes share some sequence identity but function independently on separate sets of substrates. KasA differs from KasB [EC 2.3.1.294, meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II], by preferring shorter (C-22 to C-36) and more saturated (only one double bond) substrates.",384,1.0,-0.08339502,-0.065839924,-0.15580527,-0.03040333,0.0764288,0.012706858,-0.08098094,0.06251944,0.09839825,-0.03018618,0.021106975,-0.09212511,-0.011715528,-0.04124942,-0.0140780145,-0.0181546,-0.05570544,-0.030756984,0.0036191044,-0.05702,0.03826426,0.035278827,0.010105402,-0.0121526485,-0.0061455634,-0.027543489,0.0091101695,0.032130804,-0.051599633,-0.106591396,0.0074860025,-0.08180641,0.08874465,-0.029109556,0.038421173,0.016629403,-0.08344785,-0.04985153,0.110571444,-0.032756787,0.055321097,-0.029991357,0.002394986,0.038385198,-0.018894127,-0.003407781,-0.04369891,0.028613726,-0.0013813715,4.9671395e-05,-0.098825365,-0.067982644,-0.09407813,0.06685771,-0.03734356,0.0198645,-0.099497445,0.043098148,0.0035284364,0.04417806,0.021530721,-0.0009198821,0.015128394,0.027716238,-0.023966886,-0.05609845,-0.01464108,-0.061982263,0.011582556,-0.007660955,-0.109970815,-0.0417262,-0.03447871,0.10438352,0.07148348,0.05877044,-0.012674332,-0.0014999417,0.00025520154,-0.021935813,-0.02809265,-0.030177262,-0.023082804,0.009852412,-0.0015193528,-0.099971406,0.06589869,-0.015450075,-0.0073043886,0.06410312,0.0966275,-0.047376487,0.029223833,-0.027063513,-0.04904443,0.013913401,0.07058762,0.06111956,0.039522804,-0.058250386,-0.013823413,0.02614678,0.054473583,-0.076644704,-0.06283596,3.583181e-05,-0.0980319,0.061057996,-0.0073979488,0.006416057,-0.01482849,0.007876242,-0.008899257,-0.060064994,0.032718435,0.093710236,0.05533064,-0.07553318,0.0011314035,-0.0025948728,-0.02073669,-0.030022172,0.06243234,-0.009803124,-0.04168375,0.02633121,-0.08565237,9.850864e-34,0.018759374,-0.0021083555,-0.005757983,-0.024023129,0.030763285,-0.1012724,-0.101195924,-0.0070234565,-0.07476992,0.019270003,-0.024820017,-0.05164384,0.0058384836,-0.0022149854,-0.0023103831,0.044446237,0.025736459,-0.03528752,0.038863353,0.052640706,0.026914993,0.039806638,0.04525382,-0.05107546,0.07767345,0.07845599,0.0061272667,0.005777733,0.013466063,0.014915331,0.007464727,-0.059318177,-0.07643909,0.0030722334,0.019977357,-0.02224259,-0.019948099,-0.05333058,0.021084586,0.027724374,0.050091084,0.005338663,0.016903479,-0.036163345,0.06904372,-0.020415721,-0.040564165,0.06512737,0.0069420165,0.065805085,0.010058477,-0.061375674,0.09856825,0.06357881,-0.008946499,0.010099093,-0.063705064,0.003220293,0.004386281,-0.0126083605,0.06260942,0.057545125,-0.010032233,0.105161116,-0.057868946,0.012698801,-0.088590264,-0.010024798,0.0091314195,0.12647492,-0.0068881805,-0.01934395,0.04117907,-0.023187254,0.0556779,-0.038888246,-0.11986668,0.010434151,-0.026900321,0.05199572,0.004315621,0.040084835,-0.007161751,0.021480378,-0.049015243,-0.041528203,-0.07528857,0.020593436,-0.03227506,-0.014658986,-0.014874662,-0.048775185,0.0070578367,0.07486457,-0.011499203,-4.2276974e-33,0.14172553,-0.10152142,0.13094506,-0.09420054,-0.041338563,0.04267104,0.051383495,-0.012776921,0.0018908059,-0.023347624,0.08140464,0.0067960187,-0.0011123972,-0.05754198,0.029185176,-0.0061854646,-0.03989265,0.037121452,-0.008473692,-0.04166128,0.033832688,0.089053124,0.03491536,0.05897057,0.021072172,-0.029645376,-0.035637733,0.10113205,0.020446936,0.07861835,-0.00864844,-0.005304581,0.0060068476,-0.09508747,-0.123565905,-0.043873273,-0.052635007,-0.003406904,0.017204726,0.044969995,0.075970836,0.052446764,0.0015546969,0.030032478,0.026659045,0.043975025,-0.012211174,-0.02096413,0.07513511,-0.12288878,0.01345872,-0.009713015,-0.012114706,-0.011666726,0.03883531,0.11027033,0.012283307,0.05039704,-0.038361285,-0.089967236,-0.094497025,-0.11754998,0.06026228,-0.05162422,0.058378436,0.08533125,-0.0061587817,0.02434496,0.08406143,0.017068364,0.044766996,0.0081449505,-0.06844614,0.023480603,0.03619343,-0.018663796,-0.048442375,0.021530954,-0.00312058,0.0017550732,-0.04307474,-0.06140095,0.0062915673,-0.05516299,-0.03318212,-0.042066544,-0.0037812435,0.045243632,-0.0075587155,0.03328611,-0.02454474,0.044484396,-0.030607713,0.059923474,0.003856194,-4.1200753e-08,0.07853731,-0.034916636,0.031234344,0.00940573,-0.012589159,0.04430634,-0.07268358,0.030869436,0.031172484,-0.019154996,-0.0623357,0.08421323,0.054860733,0.021730786,0.011945796,0.016689273,-0.07835598,0.007317683,0.017394548,-0.052740123,-0.047501687,-0.015773164,-0.026560156,0.057208743,0.04121602,-0.022404043,-0.025676006,0.003043841,-0.02536102,0.024728078,0.0186267,0.02691431,0.013513028,0.018933091,-0.015087804,-0.04911123,-0.025378788,-0.11457876,-0.057034574,0.06946934,0.07133396,0.008428039,-0.112246305,0.05463681,0.00044549198,0.06297041,0.034706905,0.038551904,-0.041702718,-0.028885324,0.031652197,0.04183473,-0.0459582,0.00628848,-0.030115025,0.052710954,-0.018689787,-0.061640915,-0.011455884,-0.013489767,0.07315624,-0.013148575,0.15169363,-0.052750595 +2.3.1.294,"The enzyme is part of the fatty acid synthase (FAS) II system of mycobacteria, which extends modified products of the FAS I system, eventually forming meromycolic acids that are incorporated into mycolic acids. Meromycolic acids consist of a long chain, typically 50-60 carbons, which is functionalized by different groups.Two 3-oxoacyl-(acyl carrier protein) synthases function within the FAS II system, encoded by the kasA and kasB genes. The two enzymes share some sequence identity but function independently on separate sets of substrates. KasB differs from KasA (EC 2.3.1.293, meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I), by preferring longer substrates (closer to the upper limit), which also contain two double bonds.",384,1.0,-0.08640171,-0.06493346,-0.1524875,-0.036108546,0.08496665,-0.002181573,-0.067599066,0.06616752,0.09990821,-0.030043276,0.027321698,-0.09171721,-0.020636793,-0.047884066,-0.01729532,-0.020771245,-0.05906835,-0.03164955,-0.005335845,-0.055628393,0.04823361,0.040725,0.011246832,-0.0071228095,-0.01579183,-0.027981257,0.01174184,0.034117844,-0.042162888,-0.10791168,0.011108632,-0.08552042,0.08287241,-0.025308438,0.031530045,0.027823383,-0.071240224,-0.051746797,0.09598074,-0.031122414,0.05909631,-0.03141783,-0.0016253536,0.03522022,-0.015595155,-0.005876082,-0.049356468,0.026563985,-0.007920546,0.0028843514,-0.09972006,-0.07886681,-0.086019665,0.064730614,-0.038671598,0.020343997,-0.098901,0.04477956,-0.0063139824,0.05356783,0.02092112,-0.0008338467,0.007384856,0.03150333,-0.015283713,-0.04830962,-0.01934918,-0.06957385,0.007926431,-0.00061945175,-0.10904461,-0.04000382,-0.0368689,0.11200315,0.08181222,0.05364048,-0.023277126,0.0052158553,0.0014638768,-0.019474708,-0.024455475,-0.03139167,-0.02376299,0.0030026867,-0.006084886,-0.09571905,0.06503377,-0.019909559,-0.01381567,0.06592493,0.09685463,-0.052658018,0.031386964,-0.030566227,-0.0460361,0.017847871,0.06328274,0.05560551,0.04236685,-0.053652048,-0.010274054,0.0278063,0.05325956,-0.0742206,-0.0676258,-0.00025361084,-0.10266775,0.057796385,-0.010995836,0.0072295824,-0.015769005,0.0064953966,-0.0012476627,-0.051179025,0.034751825,0.093295544,0.05965287,-0.07659488,0.015540211,-0.0035032204,-0.015087797,-0.02366924,0.0596349,-0.0037499578,-0.040074896,0.022083705,-0.082919456,5.4290615e-34,0.017999763,-0.008925201,-0.002154724,-0.027084686,0.022721773,-0.10485056,-0.10542804,-0.015097168,-0.077247,0.024648491,-0.023399912,-0.03784635,0.0054330593,0.00466281,-0.0031651487,0.041072518,0.019661339,-0.028163573,0.045187794,0.05558078,0.028362729,0.030031115,0.043028153,-0.04546882,0.0776866,0.08030078,0.0050030495,0.0043785395,0.003976573,0.016359411,0.004886236,-0.056382325,-0.07972143,0.0071958993,0.008970141,-0.011153625,-0.013928227,-0.05722022,0.023955127,0.032534488,0.047433358,0.0029270088,0.022390377,-0.032678217,0.06350411,-0.02429212,-0.036163807,0.061295442,0.008041435,0.062128074,0.01181271,-0.06904359,0.1010465,0.065514944,-0.006127501,0.018417673,-0.05947887,-0.0029143868,-0.0050706007,-0.004273424,0.0633073,0.053859193,-0.0067379773,0.1084132,-0.066821136,0.015248781,-0.094711654,-0.019560628,0.011135902,0.12893116,-0.010672264,-0.014912671,0.039251007,-0.0239518,0.046975102,-0.034201376,-0.11405135,0.012792426,-0.048543997,0.06767096,-0.00031104003,0.034663144,-0.003782419,0.015236953,-0.052743588,-0.03936749,-0.061159696,0.013124164,-0.037895482,-0.026388185,-0.01983637,-0.043169092,0.006399785,0.06928821,-0.005533692,-3.9281745e-33,0.1369149,-0.09894813,0.13625655,-0.08717552,-0.033768963,0.044202548,0.053656034,0.0002675018,0.0013980463,-0.019818025,0.071609385,0.008705297,-0.0037523585,-0.061951455,0.037336536,-0.0055550826,-0.03630314,0.034063768,0.0019214918,-0.046335705,0.031055912,0.10020675,0.04026209,0.060751736,0.024030672,-0.035646778,-0.041771926,0.10606837,0.017992152,0.0703641,-0.010654599,-0.01641921,0.005243387,-0.09304801,-0.124207936,-0.050899696,-0.053341247,0.004085216,0.02014997,0.04234974,0.077876054,0.06002774,0.0007037028,0.02553087,0.025342913,0.04669712,-0.02166147,-0.01934219,0.0650941,-0.12505817,0.013078762,0.0035603666,-0.010041982,-0.007419267,0.04171159,0.10897273,0.012136645,0.053740826,-0.041560706,-0.08135309,-0.09631099,-0.11662156,0.054890983,-0.04734839,0.061578568,0.07543466,-0.005302127,0.013288122,0.07954077,0.025959732,0.05136327,0.010115626,-0.07294463,0.026316103,0.035693202,-0.015533261,-0.05544387,0.020962832,-0.0014904445,0.006900489,-0.044140078,-0.06130442,0.008196213,-0.056039337,-0.034933988,-0.049210623,-0.0022721814,0.05461,-0.0024808971,0.028047964,-0.026266351,0.0443809,-0.036227897,0.049778577,-0.0038060895,-4.0402497e-08,0.08422076,-0.039549075,0.02505981,0.012826053,-0.016775014,0.0404658,-0.07119112,0.034499098,0.022240905,-0.024056891,-0.06235913,0.09232428,0.05888973,0.020880548,0.018473282,0.024162509,-0.06816906,0.012682098,0.015169059,-0.060398962,-0.04273002,-0.009885463,-0.03223032,0.054953404,0.04090622,-0.00958667,-0.025031328,0.011934019,-0.02509189,0.027523099,0.01985747,0.026574163,0.018440297,0.019214265,-0.02409013,-0.039489683,-0.033562522,-0.11200784,-0.060739372,0.068627685,0.06606506,0.00033473698,-0.10578171,0.05143849,-0.011530059,0.06780143,0.040634513,0.035374843,-0.027697776,-0.021688746,0.026121875,0.038180955,-0.046003472,0.008128522,-0.034451682,0.04353787,-0.0152134355,-0.06548823,-0.003948609,-0.016078576,0.07711589,-0.0042013247,0.16055955,-0.0496554 +2.3.1.295,"The enzyme, found in mycobacteria, is involved in the synthesis of beta-D-mannosyl phosphomycoketides. It is a very large polyketide synthase that contains two complete sets of FAS-like fatty acid synthase modules. It binds an acyl-CoA with 5-9 carbons as a starter unit, and extends it by five rounds of alternative additions of malonyl-CoA and methylmalonyl-CoA extender units. Depending on the starter unit, the enzyme forms mycoketide-CoAs of different lengths.",384,1.0,-0.07195419,-0.011526349,-0.08809721,-0.022115191,0.026456885,-0.006839789,-0.012461709,0.08945024,0.00512401,0.016964944,-0.0050988207,-0.07682962,0.026791558,0.014410044,-0.0982773,0.02652565,-0.023067873,-0.0111898305,0.0038046285,0.0046846587,0.022071531,0.088275045,0.029151283,-0.029876495,0.05971296,-0.022627348,0.07326537,-0.04421332,-0.026890866,-0.09240349,0.034032267,-0.055937767,0.060850218,-0.024566699,0.11053466,0.07814659,0.042379238,-0.042544805,0.09577572,0.033137772,0.05891054,-0.054938305,0.037415955,0.013228956,-0.01687442,0.044520162,-0.12274956,0.055830732,0.013601488,0.00465024,-0.08925864,-0.07289417,-0.07541892,0.056962386,0.038153432,0.025211727,-0.01908373,-0.02412582,0.005268557,0.011882577,0.053818587,0.01589479,0.018913219,0.05264037,0.010957578,-0.060573958,-0.025498787,-0.057861548,0.029257892,-0.03355032,-0.07254437,-0.0080297645,-0.066894695,0.075758,0.044860728,-0.030068,0.012118593,-0.027114961,0.042071056,0.023591511,-0.05638637,-0.009312568,0.047365,0.0075563206,-0.013139931,0.0057204906,0.1206428,-0.013144619,0.045805473,0.065595075,0.021396609,-0.08874659,0.020335438,-0.042875607,-0.057950284,-0.004659641,0.05528074,0.03106064,0.047341887,-0.026320612,-0.0073784976,-0.02137987,0.012100131,-0.033474587,-0.07512888,-0.01688982,-0.05883288,0.016878925,0.062079713,0.009557895,-0.033782538,0.013580068,0.008523013,-0.049713403,0.013102799,0.053296242,0.090030625,-0.051443666,-0.03060736,0.011368626,-0.008405453,-0.052091975,-0.02049741,0.030517386,-0.080315195,0.035293218,-0.15458328,1.1523807e-33,0.0472326,0.0022218209,0.045499656,0.020561453,0.045489233,-0.038628608,-0.11046294,0.003395741,-0.08923062,-0.051193893,-0.046704814,-0.048581492,-0.03171487,0.13776486,-0.04534701,0.021932542,0.022339394,0.041193083,0.023060283,-0.014091371,-0.01698308,0.013032083,0.0261104,0.036760926,0.05155048,0.10113103,-0.025985729,0.038041867,0.038864832,0.01482743,0.012326074,-0.055790357,-0.050578117,0.0045854556,-0.013787914,0.008589721,-0.04839539,-0.07707481,0.033750143,0.048651736,0.036124844,-0.04017746,-0.010527777,-0.041412186,0.06587116,-0.033534806,-0.040861864,0.049821638,0.003964252,0.046050064,0.0072002024,-0.0049109,0.05781972,0.02703398,-0.047116533,0.025951184,-0.06995483,-0.04646689,0.04441184,0.0042812196,0.028609142,0.08896648,-0.01541215,0.10990254,-0.054317884,-0.01866948,-0.010667121,-0.0128073655,0.036869407,0.06411571,-0.035797417,-0.027831873,0.02484001,-0.005170362,0.0740929,-0.05661368,-0.0630699,-0.048781235,-0.028010417,-0.043057308,0.08958225,0.0130066825,-0.011663813,-0.053190716,-0.015781151,-0.056758825,-0.079844475,-0.06723191,-0.03494857,0.018938826,-0.042325474,-0.08343449,-0.059137285,0.067311026,-0.032385334,-3.553122e-33,0.13659967,-0.1470378,0.107229404,-0.10785444,-0.050926097,-0.01709675,0.052038297,0.018780893,0.047382202,-0.015583271,0.048475247,-0.010572327,0.011759326,-0.034035593,-0.017643172,0.027267903,0.021315819,0.0025547547,0.0022239254,-0.02801193,0.007577038,0.048579708,0.0338293,-0.0068856,0.009095849,-0.022733878,-0.06746648,0.09085575,0.0021194753,0.06881445,-0.054173786,-0.03966187,0.017940944,-0.078011766,-0.09165661,0.0126547245,-0.10030865,0.006829748,0.025111234,0.011750721,-0.008341477,0.0019515684,0.01239996,-0.03065672,0.014143255,0.014010543,-0.043071847,-0.021832164,0.01431687,-0.08727443,-0.004987183,-0.011556032,0.04834953,0.023684869,0.015365173,0.07108537,-0.0012721762,0.051884677,-0.014953631,-0.07619371,-0.048617426,-0.064074956,0.04299596,0.013149085,0.06356749,0.12371584,0.0070190933,0.030121077,0.033502623,-0.015019812,0.06798325,0.043543324,-0.009843358,0.025121162,-0.033416666,-0.07343912,-0.09217199,0.004312435,-0.013290712,0.010119005,-0.05717329,-0.04811261,0.009072475,-0.08120529,-0.03780359,-0.050568607,0.048697006,0.11688282,-0.028296249,0.07838784,-0.032009926,0.1284459,-0.038234696,0.04601009,0.06433596,-4.071893e-08,0.059716467,-0.05523972,0.026326215,-0.018104028,0.06590599,-0.0010524384,-0.03273458,-0.018379897,-0.00502702,-0.0007987159,-0.03352193,0.10009502,0.0642667,0.0055323276,0.06602597,-0.0023310974,-0.05792138,-0.026577283,-0.005458256,-0.035690073,-0.07450642,0.07206719,0.04824313,0.056654435,0.010137482,-0.011626418,0.05892688,0.044339795,-0.038267,0.06102587,0.0011434472,0.08541273,-0.056259345,-0.05737914,-0.08628972,0.016097808,-0.067222595,-0.08971161,-0.014667431,0.04521395,0.081165455,0.016654136,-0.0075907595,0.028177274,-0.021103011,0.04440609,-0.023554724,-0.03440661,-0.01927415,0.006010038,0.02943724,0.06764733,-0.09088688,-0.010932533,-0.059846923,0.06483294,-0.050655782,-0.031160437,-0.08147968,-0.029736863,0.019976187,-0.034104545,0.1608218,-0.04363324 +2.3.1.296,"The enzyme participates in the production of acylceramides in the stratum corneum, the outermost layer of the epidermis. Acylceramides are crucial components of the skin permeability barrier.",384,1.0,0.03952823,-0.04230698,-0.041418206,-0.0034939754,0.06796797,0.05962399,0.047899026,0.06295807,-0.06653591,0.005272028,0.071233496,-0.0962052,-0.07853359,0.008870046,-0.055750076,0.013848431,0.012663063,-0.00835007,0.01886292,-0.06213453,0.06963685,0.027149953,-0.022794222,-0.04433328,-0.0070495876,-0.035965346,0.0053051654,-0.021300096,-0.014204803,-0.06673748,-0.010320207,-0.0979212,-0.036613747,-0.014595584,0.020728491,-0.0029721665,-0.11642729,0.020524066,0.022513654,0.04961435,-0.013600701,-0.05137975,-0.09239578,0.041051067,0.028058458,-0.039630257,0.099726185,0.058580797,-0.008367194,0.060094874,-0.004135702,-0.052420847,0.0012650905,-0.025114106,-0.100838594,0.060144752,-0.1035963,-0.011444334,-0.07849506,0.00033204156,-0.010230097,-0.010219063,-0.017896926,0.009329188,0.0031601596,-0.08066449,0.06724094,-0.02502545,-0.03764225,-0.0073235068,-0.010667089,-0.058272664,0.0070523415,-0.0019528794,0.042555798,-0.0025863084,-0.0627577,-0.026267782,0.026713908,0.03275869,0.07458021,-0.017455027,0.030448627,0.051132645,0.0025682645,0.037501458,0.046576586,-0.034355212,-0.021523621,-0.058352232,0.04151322,0.003596646,-0.059724167,-0.002418531,0.046821125,0.015467271,0.0055845105,0.01240354,0.018754954,-0.039961487,-0.06950163,-0.041748587,-0.0007370661,0.019012177,-0.08214605,-0.038708966,-0.056156285,0.021572514,-0.024898678,0.009201198,0.036776993,0.019227559,-0.01679498,-0.015868763,0.015408308,-0.0055934433,0.014862772,-0.029857635,0.07740996,-0.013443413,-0.015207169,0.057717454,0.008578075,0.04518762,0.024502154,-0.0025472224,0.0028620334,3.9754053e-34,-0.016556285,0.069245294,-0.057841215,-0.061591096,-0.034409154,-0.0061101234,-0.017853457,-0.0710539,-0.057454903,0.024656257,-0.07981111,-0.051236097,-0.0032998377,0.07489222,0.05954695,0.04218199,0.031278778,0.006827235,0.07579026,-0.06713045,0.010091836,0.051637724,-0.041086342,0.042950064,-0.050056193,0.08214597,-0.06119653,0.009191353,0.0059640463,-0.01737382,0.018879868,0.040181648,0.0047528897,0.01931465,0.09172477,0.12777494,0.011573585,-0.02084666,0.0025250658,-0.03150248,-0.03598318,0.027774803,0.12170296,-0.05569305,0.016892653,-0.07102647,-0.08968999,0.09692554,0.017918406,0.062206887,0.06588484,0.024527464,0.11584299,-0.0034470332,0.0016872894,0.0107713165,-0.08758262,0.00974449,-0.027792146,0.05957013,-0.031170882,0.010022944,-0.010904983,0.018657112,-0.007255797,0.05017043,-0.054066278,0.0264371,-0.015066906,0.052202158,-0.07810997,0.027277844,0.08121715,0.024550982,0.015406397,0.024962729,-0.06269585,0.10740127,-0.03643958,-0.051680665,-0.038817067,0.016326727,0.0267654,-0.070645854,0.02477715,9.810078e-05,-0.028779738,0.0733947,0.04019725,-0.01717503,0.089464925,0.022080958,-0.0284086,0.06476823,-0.0139754275,-2.5223229e-33,0.0798421,-0.09442354,0.053456955,-0.049977243,-0.026126197,0.063894,0.042185143,0.10662127,-0.03878038,0.03152467,0.023516959,0.06012223,-0.04644354,-0.11682467,-0.017218698,0.0055779717,-0.024319,0.083355404,0.022347003,-0.06373413,-0.054340668,0.046296123,0.03874468,0.028261563,0.022456449,-0.023472967,0.002473522,-0.037493303,0.021073803,-0.03448951,0.016848907,-0.05870167,-0.036790494,-0.053144652,-0.037668247,0.007851288,-0.077197045,-0.012783395,0.01091048,0.061511155,0.04537175,-0.04648783,0.021571562,0.07651344,0.09456906,0.07231516,-0.11894258,-0.042391993,-0.045106232,-0.12442235,-0.0016623203,-0.002126447,0.0886388,-0.084672816,0.102769665,0.11328502,0.03905461,-0.06261191,0.073536426,0.027250888,0.018696439,-0.05439312,0.012932842,0.027753655,0.061061487,-0.032915495,-0.06909602,0.041917816,0.0066238204,0.042990472,0.044014625,0.013840451,-0.08381975,0.008872247,-0.072936416,-0.022696715,-0.033952054,0.013492059,0.0062003657,0.064363115,-0.027696945,0.02768857,0.0049946113,0.002159383,0.086894795,0.021329336,-0.019624028,0.00024762668,-0.011212842,-0.02652386,-0.0329113,-0.017609283,-0.029191088,-0.03235632,0.009845888,-2.8932677e-08,0.11141807,-0.03449447,0.026386563,-0.1305988,-0.07854976,0.08883755,0.07322579,0.016003668,0.05003542,-0.007066173,-0.08973854,0.063356794,0.055917155,0.07154427,-0.01851521,0.04820781,0.0025744494,-0.014775921,-0.024455631,-0.14776057,-0.09310364,-0.014537519,-0.03287064,0.047427494,0.01754628,-0.027389962,0.07219846,0.09115273,-0.10678804,0.11743468,-0.06857587,-0.04337958,0.029022148,0.02384825,0.0010051699,0.07616423,0.05789119,-0.0709992,-0.0216547,0.0015046197,-0.032491647,-0.07515889,0.030546697,-0.001061491,0.042582244,0.0016608238,0.055627353,-0.0036482504,-0.008035518,-0.044106703,0.00791496,-0.045165032,-0.0880886,0.0035957438,-0.08084273,-0.048858568,-0.050222795,-0.047933858,0.00935814,-0.05328235,-0.0021593468,0.02682122,0.10428061,0.050994985 +2.3.1.297,"This entry describes ceramide synthase enzymes that are specific for very-long-chain fatty acyl-CoA substrates. The two isoforms from yeast and the plant LOH1 and LOH3 isoforms transfer 24:0 and 26:0 acyl chains preferentially and use phytosphingosine as the preferred sphingoid base. The mammalian CERS2 isoform is specific for acyl donors of 20-26 carbons, which can be saturated or unsaturated. The mammalian CERS3 isoform catalyses this activity, but has a broader substrate range and also catalyses the activity of EC 2.3.1.298, ultra-long-chain ceramide synthase. Both mammalian enzymes can use multiple sphingoid bases, including sphinganine, sphingosine, and phytosphingosine.",384,1.0,-0.08764471,-0.0978934,-0.06286969,-0.059897896,0.06756923,0.017761867,-0.13542101,0.03982095,0.04805143,-0.043164074,0.111271925,-0.14379248,-0.09229474,0.03112363,0.044533283,-0.0016247224,-0.05256875,0.019892104,0.055332962,-0.10953858,0.04123823,0.03715752,-0.030042361,0.06094564,-0.0037229508,-0.11337542,0.014944973,-0.059899397,0.02245538,-0.07663009,0.08819951,-0.062527396,0.053667687,-0.02727923,0.0020013463,-0.009325554,-0.025489813,-0.08853896,0.06062289,-0.010543911,0.06736886,-0.05211401,0.018803114,-0.06463228,-0.02194322,-0.006399558,-0.017810293,0.028879233,0.015638921,-0.0061278082,0.014906063,-0.08074908,-0.060345173,0.035911374,-0.05428389,0.011731106,-0.06533905,0.048670243,0.0016932002,0.03195989,-0.016411437,0.0139941005,0.020396564,0.002316555,-0.022985391,-0.029914657,-0.003943332,-0.053120077,-0.0029817002,0.017490664,-0.07725348,-0.13024099,0.0047281818,0.10531735,-0.005357333,0.078587934,0.0075490144,-0.022409765,0.024259245,-0.07928814,-0.037144963,-0.00016290839,0.04552304,0.04223842,0.0383375,0.023545668,0.01991549,0.061187733,0.0015379571,0.034321785,0.09847618,-0.05332814,-0.028499238,0.0646829,-0.032463554,0.1026404,0.038775314,0.07481328,0.044227168,-0.082208894,0.018256346,0.07074648,0.0076897293,-0.09831882,0.008879905,0.050085507,0.00065494125,0.058665548,-0.024223184,0.021970868,0.05796292,0.015533985,0.04462475,-0.029593887,0.04077278,0.045018837,-0.026707469,-0.05191145,-0.021090483,-0.006507983,-0.014825064,0.009405345,-0.002047177,0.03671841,-0.06930323,-3.0022315e-05,-0.015207119,5.2409585e-33,-0.0035867998,0.044757884,0.01751861,0.029263888,-0.05366297,-0.028842231,-0.055394527,0.09147152,-0.10089509,-0.016540706,-0.0147682335,-0.01360988,0.007872881,0.038031526,0.019618725,-0.08458805,0.059937987,0.020810269,0.08330314,-0.05197263,-0.01445197,-0.019589495,0.011227166,-0.054169636,0.1017691,0.017907917,-0.07929959,0.038860966,-0.014843737,-0.019675763,-0.04854062,-0.055244282,-0.030559743,0.05709411,-0.024958825,-0.03033687,0.033738256,-0.050492927,-0.036865875,0.06673589,0.06359277,0.0164781,0.03482758,-0.041904155,0.04372086,-0.008457338,-0.087559864,0.0020222645,0.031912457,0.03378226,0.041094884,-0.009787562,0.067344956,0.013383492,0.016173203,-0.019502126,-0.057081334,-0.06486148,-0.006335399,-0.029678108,-0.045985628,0.10700345,-0.056611408,0.031581964,-0.013250515,-0.010722749,-0.09580216,-0.021479733,-0.118725374,0.027048744,-0.012072094,-0.024870927,0.08821412,0.031083407,0.03605308,-0.047410693,-0.07638196,0.007561713,-0.02474479,0.0292725,-0.03487652,0.02625662,-0.045337357,0.01675264,-0.0007132055,0.017365968,-0.045750737,0.041050922,0.048807304,0.035196003,0.03460975,-0.09801772,-0.012428398,0.06798657,-0.046461727,-4.9444396e-33,0.079473846,-0.03173917,0.03524508,-0.12063625,-0.011237753,0.038380068,0.019679336,0.008083189,0.07550163,-0.019057386,0.007920096,-0.01264033,0.02502985,-0.12729071,0.01573242,0.014900875,-0.040353693,0.057913534,-0.041846674,-0.057377983,0.068515934,0.029005175,-0.08062188,0.1199782,0.023713699,0.07742725,-0.016975068,0.08167991,0.059467096,0.072918445,-0.065116964,-0.016103849,0.024561744,-0.027553579,0.022172788,-0.034757096,-0.031097077,0.083317146,0.018033389,0.006688869,-0.030905034,0.08322402,-0.040961303,0.08466655,0.09723006,0.11300228,0.029298717,-0.0073618437,-0.017038418,0.010235618,0.006882843,-0.020843267,-0.019712992,0.02525465,0.035323422,0.03156486,-0.050412785,0.018426767,0.034581587,-0.097564094,-0.02950657,-0.038297545,-0.02311569,-0.028984813,0.055834565,0.043841828,-0.08187002,0.062255085,-0.031666346,0.017242035,0.04091742,-0.023728158,-0.05842315,-0.041229714,-0.02975436,0.0002970584,-0.028213797,-0.09295212,-0.028340722,-0.022376243,0.0048738765,-0.036835857,0.10057405,-0.040497903,0.033504494,0.049287595,-0.026850428,0.003062381,0.029815314,-0.0014745791,-0.022525692,-0.0040077795,0.033599503,0.051985852,0.088164315,-4.0542677e-08,0.027736027,0.020202328,0.01876499,-0.06213486,-0.026162017,0.017157894,0.04017796,0.015435738,0.045978114,-0.022978732,-0.10522963,0.055282664,0.070795655,0.042583197,0.061292257,0.04193267,-0.0025417553,-0.0033272752,0.015234814,-0.041138716,0.0020799069,-0.013790189,-0.054245684,0.06276656,-0.01537749,-0.015867772,0.00870621,0.097323194,0.01072052,0.021296157,0.0022794777,0.027256358,0.045050126,0.07418093,0.09573982,-0.017149515,-0.015406761,-0.09854098,-0.024104074,0.08504915,0.020278685,-0.060831297,-0.05706312,0.008805876,0.044508267,-0.010470618,0.0142631605,0.030686801,0.0026138884,-0.038575366,-0.007282046,-0.044621836,-0.05554574,-0.038732708,-0.082873665,-0.04955032,-0.055584144,-0.0024051364,-0.00093010656,-0.089363106,0.037442274,0.005716412,0.16614644,-0.0312744 +2.3.1.298,"Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 3 (CERS3) is the only enzyme that is active with ultra-long-chain acyl-CoA donors (C28 or longer). It is active in the epidermis, where its products are incorporated into acylceramides. CERS3 also accepts (2R)-2-hydroxy fatty acids and omega-hydroxy fatty acids, and can accept very-long-chain acyl-CoA substrates (see EC 2.3.1.297, very-long-chain ceramide synthase). It can use multiple sphingoid bases including sphinganine, sphingosine, phytosphingosine, and (6R)-6-hydroxysphingosine.",384,1.0,-0.06819374,-0.15279232,-0.084782846,-0.080641896,0.052266598,0.0105380155,-0.11702898,0.05835551,0.03381761,-0.034477014,0.086209,-0.12328506,-0.06936481,0.07426381,0.030553138,0.019695971,-0.08296432,0.040964846,0.06617614,-0.09295228,0.0052249217,0.030132508,0.007052132,0.06240488,-0.026556693,-0.0956315,0.02959256,-0.053722184,0.016708095,-0.05688955,0.045492817,-0.049928617,0.019578684,-0.032992702,0.028906904,-0.011309955,-0.06896802,-0.04330389,0.033300817,0.023801798,0.09403576,-0.0055328566,0.026565572,-0.05369627,-0.0155203985,-0.03637846,-0.037215322,0.0129334,0.025845356,0.03338606,0.032268994,-0.08745851,-0.048332162,0.06330172,-0.08769979,-0.014984137,-0.11450539,0.033336163,0.0109767495,0.039085094,-0.0039758272,0.0080931885,0.033697814,-0.014828093,0.027056921,0.003965245,0.006124353,-0.056744464,-0.063660756,0.054006737,-0.08547087,-0.108145304,0.045713935,0.13863753,0.005135608,0.066018574,0.01397014,-0.008159398,0.007660734,-0.09642779,-0.051560543,-0.022290023,0.00033598088,0.095572464,0.04181859,0.029297872,-0.0101496745,0.047230907,-0.030175805,0.01659,0.093046635,-0.031454343,-0.070108265,-0.00057991355,-0.03479462,0.09712212,0.0045506298,0.051126182,0.039871436,-0.072128214,0.0033856565,0.04909136,0.020713111,-0.06820835,0.00060871185,0.03496193,-0.054156948,0.06869074,-0.042554498,0.0327607,0.019759012,0.030812817,0.036549475,-0.032472067,0.029004937,0.022232573,-0.052023087,-0.07336227,0.013955363,0.0059978357,0.01854764,0.024029123,0.033806935,0.024585163,-0.021881407,0.015269705,0.02922465,3.4255485e-33,-0.0058599547,0.059217464,0.04210333,0.024541108,-0.04206012,0.018130982,-0.034051713,0.062192544,-0.11885448,-0.0020561528,0.006821613,-0.0033064506,0.06192563,0.04122228,0.05028137,-0.06133679,0.044180986,0.031784277,0.060933676,-0.06771997,0.018913077,0.010562611,-0.023028852,-0.009369667,0.03613116,0.023510361,-0.09129706,0.06773014,0.014665444,-0.033773273,-0.06438884,-0.008445303,-0.03445784,0.050529607,-0.010225581,-0.014910508,0.02701948,-0.097003885,-0.02534166,0.09760201,0.073683016,0.00025502604,0.047732536,-0.021489004,0.045707185,-0.009060085,-0.064380154,-0.018300809,-0.016609868,0.005078152,0.08041105,-0.007041605,0.063026816,-0.031017048,0.01740539,-0.014613972,-0.061070327,-0.020750843,0.018827783,-0.007737165,-0.03188956,0.07704046,-0.075157724,0.040108323,-0.002202794,0.027535144,-0.0847221,-0.03132577,-0.102067836,0.006812104,-0.009371085,-0.04157717,0.06318036,0.0659917,0.03844973,-0.010554511,-0.07850251,0.041875307,-0.027056117,-0.010647555,-0.03515884,0.018276058,-0.023857279,0.05616005,0.014723147,-0.020261966,-0.049205262,0.02851638,0.03883726,0.006282166,0.04556206,-0.08552965,-0.011290346,0.05598096,-0.054558758,-2.9412854e-33,0.069291174,-0.037351236,0.053860404,-0.112655856,-0.0040253256,0.02983246,0.025121689,0.041572608,0.07973393,-0.05034024,0.05962886,-0.015605498,0.025548276,-0.1229229,-0.0066781724,0.056734063,-0.007708918,0.042697325,-0.027676698,-0.09535671,0.0891324,0.041232597,-0.05840935,0.11407601,-0.010059458,0.075312234,-0.026752805,0.050894618,0.054928947,0.07381779,-0.055713747,-0.039205965,0.039122906,-0.014889324,0.03187486,-0.062092125,-0.021341374,0.046689965,0.043105755,0.007841898,-0.020119892,0.04974305,0.0087398235,0.09884596,0.11757754,0.10635239,0.0020794333,0.0025919573,-0.021511244,0.01721789,-0.038879145,-0.032539245,0.012460525,-0.017019942,0.06920434,0.010643931,-0.0038864594,-0.060661376,0.076151386,-0.081417225,-0.031028308,-0.03468743,-0.005687832,-0.0072496217,0.048908237,0.05014119,-0.08242252,0.056936815,-0.0033676345,-0.004880691,0.04660203,0.0006943642,-0.06947757,-0.06262393,-0.03681146,0.006233465,-0.022121606,-0.083366014,0.020561649,-0.0036092682,-0.020039024,-0.039780013,0.093458235,-0.009313651,0.042461168,0.04139595,-0.026459586,0.0034598883,0.029862208,-0.026863556,-0.012025376,0.009000259,0.053235624,0.047899637,0.076230854,-4.3573458e-08,0.07074816,0.02166585,0.0013114489,-0.08986398,0.0076765534,0.0036046822,0.007214896,0.0074847504,0.039887175,-0.023562081,-0.09119693,0.017697671,0.03318766,0.049900573,0.06330714,0.02129501,0.0072118654,-0.0005377686,-0.02092141,-0.06760238,-0.04212152,0.012367133,0.0028284497,0.033771753,-0.0090865195,0.008971799,0.026967337,0.05756935,-0.010946733,0.062101748,-0.023414843,0.011976849,0.008336815,0.07674202,0.080682166,-0.016455157,-0.006182809,-0.08035745,-0.01567486,0.09670175,0.005374603,-0.056053434,-0.07508412,0.0194283,0.06473888,-0.017138716,-0.0026268528,-0.017688766,-0.00477589,-0.070025116,-0.02244898,-0.07398475,-0.04479681,-0.044089172,-0.08917454,-0.046683997,-0.051847562,0.00084043347,-0.035699002,-0.09244625,0.010102568,0.015244041,0.18526034,0.03737744 +2.3.1.299,"Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 1 (CERS1) is structurally and functionally distinctive from all other CERS enzymes, and is specific for stearoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.",384,1.0,-0.10130252,-0.12257713,-0.076569654,-0.051389497,0.024956735,0.0017354533,-0.11771298,0.0733703,0.045523815,-0.047397163,0.097935036,-0.15226935,-0.060516693,0.059291065,-0.019823274,0.013148516,-0.09819311,0.0068597733,0.09255553,-0.09076416,-0.039241984,0.06864959,-0.023305073,0.04029561,-0.002081327,-0.09810706,-0.0063352184,-0.040606044,0.03511693,-0.075524434,0.07963068,-0.03335311,0.03324989,-0.0063270056,0.042644612,-0.001928973,0.0034664879,-0.034731984,0.07031164,0.008600495,0.08530767,0.007003783,0.033028968,-0.08179249,-0.03319414,-0.018156163,-0.037475016,0.05757894,-0.0032478652,0.01842956,0.042504553,-0.06544113,-0.09413953,0.05382447,-0.069579534,0.023215242,-0.098758936,0.026658667,0.0135968905,0.018009758,-0.020499941,0.018102713,0.0076123583,0.007908071,0.018260427,0.0064682607,0.034846324,-0.06173946,-0.04104318,0.028698146,-0.06663579,-0.09677967,0.013185874,0.12694329,-0.01383422,0.03599638,-0.041336253,-0.027478611,0.011939111,-0.09599365,-0.04085562,-0.006472705,0.0029169184,0.033913385,0.038861845,0.031895068,0.042726874,0.029396556,0.028786771,-0.028484235,0.10846886,-0.052545946,-0.035069652,-0.010151472,-0.06846124,0.09629313,0.016221937,0.07223207,0.06007205,-0.09291777,0.0034482859,0.021462996,0.062438264,-0.04738841,-0.004938228,0.011631051,-0.025125008,0.06849763,-0.024232365,-0.0025586772,0.023028826,0.017860064,0.07410697,-0.0225066,0.062413212,0.019559707,-0.07690591,-0.022134569,0.009688861,0.024941504,0.00045892314,0.015809977,-0.0034608818,0.050635584,-0.012618411,-0.014882511,-0.022876311,5.0786425e-33,0.04789681,0.054265767,0.06265438,0.014493394,-0.00733493,-0.015187203,-0.051039424,0.10298973,-0.11271243,-0.005047633,-0.009960582,-0.015616979,0.023495445,0.004367553,0.021241637,-0.047830053,0.039663445,0.013607291,0.0566091,-0.074089035,-0.038520012,0.028071506,0.002588766,-0.022713896,0.051270857,0.006818176,-0.08330282,0.045992196,-0.04825491,-0.02886801,-0.11460574,-0.014663051,-0.052696023,0.063601024,-0.013276361,-0.042537298,0.06357021,-0.099105254,-0.022958329,0.068987384,0.049408276,0.01642692,0.00561269,-0.01681894,0.06781833,-0.005089907,-0.11013147,-0.010528822,-0.027286079,0.013182449,0.029076343,0.014182189,0.049437124,0.0014588896,0.01526252,-0.004889206,-0.046171647,-0.068384394,-0.0032632737,-0.002098653,-0.0034190032,0.104538485,-0.095471226,0.0031861404,0.0009186697,-0.012953548,-0.047720235,-0.035063833,-0.09037391,0.020520926,-0.05101001,-0.046292186,0.030787947,0.04154018,0.02874947,0.002048956,-0.0382042,0.039843142,-0.0058928863,0.017580345,-0.05678298,0.03029413,-0.044661686,0.023298217,0.011367974,-0.0006602884,0.0011206686,0.003935045,0.0301112,0.019060519,0.06433305,-0.071118616,-0.0072087743,0.012267282,-0.006383853,-4.751027e-33,0.014927758,-0.057058014,0.070990175,-0.10014455,-0.03981447,0.045594018,-0.005921272,0.009992158,0.100903355,-0.017423242,0.037027147,0.019136067,0.017449262,-0.15141165,-0.011547682,0.03263174,0.028828207,0.052532412,-0.0058391984,-0.05682778,0.06738342,0.05729732,-0.08098575,0.066586755,-0.0033170627,0.081323706,-0.04288983,0.06286153,0.09071944,0.07694505,-0.055612195,-0.013343972,0.06062062,-0.02582871,0.0055808905,-0.047273014,-0.012266914,0.0805258,0.05945279,0.034756128,-0.033705626,0.082384795,-0.0023107512,0.08097977,0.11781757,0.056629505,0.03127544,-0.005111534,-0.04981793,-0.016775498,-0.018776855,0.025148831,-0.016352521,-0.036748633,0.029083185,-0.0034556894,0.009541363,-0.022385422,0.052835267,-0.102595076,-0.022043308,-0.016100466,-0.03324727,-0.0005385665,0.05500598,0.030359304,-0.052127562,0.056967366,-0.01387508,-0.017664025,0.07683743,-0.015509132,-0.041811086,-0.05053922,-0.027510535,0.00034317383,-0.032836907,-0.1030087,0.004357954,-0.0035430044,-0.028119067,-0.029499948,0.085472904,-0.04635556,0.018748334,0.06957431,-0.013280633,0.008023328,0.08361122,0.006845622,-0.02531383,0.012174315,0.039018907,0.06354839,0.03685682,-3.7805968e-08,0.023044342,-0.009615238,-0.0073483866,-0.08864643,-0.0024498722,0.015547287,-0.006538234,-0.0033885092,0.03787562,-0.01962227,-0.07477253,0.054945294,0.03313988,0.048504673,0.055079665,0.063392356,-0.0338113,-0.013547301,-0.011337783,-0.027872385,0.015535561,0.027957521,-0.0015753667,0.037972018,-0.04516715,-0.02109736,0.024303174,0.08573288,0.0021150555,0.03131667,-0.013944747,0.021827536,0.031239932,0.05681297,0.12097239,-0.018505927,0.021967027,-0.084063195,-0.008125282,0.07041393,0.0084594805,-0.09606449,-0.08194939,0.04031066,0.08134186,0.035892442,0.037993588,-0.033876553,-0.015555466,-0.05682826,-0.047270123,-0.029409338,-0.03089149,-0.04474139,-0.10713,-0.034803715,-0.0405832,0.0062081693,-0.02237306,-0.08242834,-0.011880375,0.05038881,0.19532782,0.0027124623 +2.6.1.116,"The enzyme, characterized from the bacterium Arthrobacter sp. KI72, participates in the degradation of nylon-6. Glyoxylate can serve as an alternative amino group acceptor with similar efficiency.",384,1.0,-0.1036362,-0.036645755,-0.02524857,0.014976156,0.031807914,0.04750305,-0.00031766103,-0.01308594,-0.008631087,0.036895774,0.014463357,0.042173427,-0.06858673,0.06991138,-0.040084563,0.047485463,-0.055928044,-0.008506774,-0.038886596,0.047246248,-0.00085815514,0.05331826,-0.0497886,-0.030611603,0.05831854,0.024570262,0.019892924,-0.022917166,0.03523879,-0.03986274,-0.0074879746,-0.03635307,0.07349665,-0.00760435,0.07540055,0.12623659,-0.020536968,-0.10075641,-0.035006892,0.020822672,-0.0073180944,0.06988683,-0.006084389,-0.1081836,-0.047401093,0.004283611,0.037957136,-0.0060272156,0.06488377,0.0022528635,0.0027127117,-0.060419995,-0.030777665,-0.020334942,0.086852975,-0.03635329,-0.07558772,-0.08628919,-0.074458696,0.0019653167,0.0245974,0.030002324,0.05601723,0.038208604,-0.008267314,-0.06328312,0.0835867,0.030989341,-0.038879745,-0.02499076,-0.09185068,-0.05159822,-0.034683127,0.07818647,0.0011209119,-0.025964694,-0.052563667,-0.049213745,0.062828146,-0.02793227,-0.006796582,-0.039579626,0.03804366,0.09955447,-1.7351382e-05,-0.0024588294,0.031497803,-0.0030909812,0.004754711,-0.017461637,0.067803375,0.013961348,0.04534181,-0.10595602,0.0025427656,-0.008542888,0.03159279,0.02690689,0.028921744,0.00067445624,-0.020754782,0.064035945,-0.033038653,-0.1372939,-0.019440066,-0.03860608,-0.021120565,0.1429628,0.064072646,0.022676826,-0.040794767,0.052972734,0.08319239,-0.023902003,-0.032931067,0.053761713,0.021480842,-0.0062653664,-0.03871236,0.045786824,-0.029964471,0.004042992,0.09343146,0.061380137,-0.050766546,0.015736338,-0.020099357,-8.602082e-34,0.056027588,-0.027883256,0.052919306,-0.043479383,0.010181329,-0.048417803,-0.08319382,-0.023778463,-0.0034500977,-0.058472756,-0.053829424,-0.0762922,0.041974265,0.046571665,0.09557751,0.07019193,-0.05382339,-0.015966682,0.05914592,0.043772798,0.044759076,0.00753326,0.019240692,0.0103835,0.02399033,0.08810387,0.023127992,0.040983316,-0.053606875,-0.02393606,0.054419212,-0.061966144,-0.11766582,0.028006636,0.011627197,-0.021700637,-0.04332382,-0.0119647365,-0.023360562,0.04081806,0.03160544,0.028301053,-0.031905133,-0.0017757657,0.096922845,-0.0110864015,0.013204425,0.12098528,-0.010033641,0.063474365,0.05615012,0.0032818809,0.068740346,-0.023749296,-0.080052085,0.06012993,0.068524085,-0.037640017,0.020622948,0.0041750856,0.034153786,0.060634777,-0.0019072236,0.020849148,0.045074157,0.0010310635,-0.005075141,-0.017287564,-0.018715749,0.06386522,-0.065690316,-0.053626444,0.041467853,0.05914682,-0.029682377,-0.07403686,-0.07012284,-0.04642941,0.04291494,-0.04288293,-0.008005978,-0.0016921986,0.0077856695,-0.06239352,-0.05342665,-0.046269804,0.02451574,-0.07986314,-0.017450543,0.054032914,0.09396881,-0.10100938,-0.14664392,0.015087173,-0.05679698,-1.4266067e-33,0.1425493,-0.048865847,0.018832667,0.008488725,-0.039560486,-0.03146479,0.04478927,0.05616473,-0.0016624879,-0.032134928,0.12900354,0.0374922,0.08192186,0.031283762,0.08892471,0.04038551,-0.058500145,0.03991259,-0.015497629,-0.058610715,0.0014752577,-0.008776486,0.015529356,-0.06685176,0.0117821945,0.0070908493,-0.049303167,0.067819186,0.07472953,0.00043685373,0.006003747,0.002685027,-0.03711047,-0.04899001,-0.039378487,0.038716517,-0.07208869,0.0016408835,-0.0041952217,-0.06222697,0.08149099,0.058309354,0.02230965,0.062112696,0.0065821433,0.04517217,-0.075827815,-0.04633939,0.0008727164,-0.07565143,0.019148445,0.017265782,0.010258536,-0.009605199,-0.0018349602,0.055209406,-0.026222613,-0.027672367,-0.08196073,0.067380674,-0.01937522,-0.03710548,0.08171079,0.04122741,-0.023888657,0.05902391,0.0055876095,0.046653904,-0.024575787,-0.056603532,0.05713907,-0.042120893,0.06466581,0.03574052,0.013148981,-0.017724572,-0.097632475,0.049831364,0.029083986,-0.0069334502,-0.015261642,-0.0006432117,-0.040059827,-0.017496571,0.010080489,-0.041613672,0.008728766,0.12080222,0.011931629,0.022872748,-0.008283218,-0.044322442,-0.033354107,0.018492987,0.013470269,-3.081432e-08,-0.026864523,-0.07601995,0.08370326,-0.10065264,0.0075155636,0.061581746,-0.007243134,0.047283996,0.0027845022,-0.057967484,0.045609422,0.07326248,-0.0738931,-0.039152034,-0.026966326,0.044658273,-0.122819,-0.0377787,-0.030366864,-0.020437345,-0.06260408,-0.018204985,-0.040580124,0.06627984,-0.001904319,-0.028865742,-0.031186564,0.06673332,-0.050038505,-0.02255027,-0.050301053,0.037637275,-0.043009464,0.016424717,-0.1168829,-0.0047750263,-0.0409944,-0.04879806,-0.02229289,0.051641032,0.016537353,-0.024458595,-0.11436816,-0.024049656,0.06253392,0.022643395,0.004237479,-0.00328226,-0.09081389,0.014677295,0.05879696,-0.019758046,-0.017524801,-0.040600073,-0.09573538,0.0033669276,-0.04260391,-0.04564352,-0.03736283,0.018866144,-0.02931294,-0.046297386,0.15729766,0.012848313 +2.6.1.117,"A pyridoxal-phosphate protein. The enzyme, found in both prokaryotes and eukaryotes, catalyses the last reaction in a methionine salvage pathway. In mammals this activity is catalysed by the multifunctional glutamine transaminase K (cf. EC 2.6.1.64, glutamine---phenylpyruvate transaminase).",384,1.0,-0.073564775,-0.03719773,-0.073466204,-0.0058881617,0.03180722,0.01176184,-0.032906283,0.05804846,0.016924333,0.061977345,0.022759913,-0.01017365,-0.072439596,0.097784385,-0.017956613,0.02178789,-0.10468874,0.021288935,0.026705485,-0.061689556,0.07592808,0.0845789,0.019872833,-0.061349154,0.032098483,0.047959633,0.03457955,-0.016896226,0.05070238,-0.028251354,-0.052580103,-0.05509906,0.047027495,-0.059680752,0.090803854,0.14129598,-0.10893067,-0.041598473,0.06835571,-0.06538574,0.064530745,-0.044400547,-0.012340497,-0.022105498,-0.013454546,0.029080478,0.033193015,0.01617723,0.04961455,-0.030419772,-0.02943404,-0.023242587,-0.051523633,0.021698538,0.058370233,0.052592155,-0.020982752,0.006098038,-0.007420004,-0.03808316,-0.033294998,-0.04558491,-0.03144494,-0.055172786,0.0785209,-0.096321106,0.04509942,-0.040027007,0.05021095,-0.026242748,-0.009443396,-0.043576848,0.062373333,-0.0063383356,-0.07898667,0.010886261,-0.055720408,0.012899635,-0.024091888,0.00683467,0.06723101,-0.06469462,0.017450722,0.033843994,0.06479432,-0.013824425,-0.047561023,0.012697478,0.035383936,-0.042964667,-0.012013838,0.010708751,-0.012681976,-0.031478845,-0.08320077,0.03184803,-0.009331294,0.031657163,0.004754474,-0.015259642,-0.019718414,0.048783235,-0.03658921,-0.044114,-0.056529284,0.019003874,-0.04276835,0.10962819,0.01842133,0.022355057,-0.042934317,0.032195494,0.033216327,0.010350885,0.020147797,0.076043285,0.031243233,-0.025579678,-0.042364128,0.05776774,0.004240544,-0.014266046,0.06962751,0.07966864,-0.044196915,0.031296056,-0.02152999,2.7975842e-33,0.072383635,0.05902195,0.01129023,-0.0034784134,-0.01895372,0.008542194,-0.096338056,0.009965327,-0.024353428,-0.105187945,-0.08111488,-0.035599098,0.060474828,-0.0023213373,-0.07913196,-0.02465689,-0.03980867,-0.010793878,0.10618216,-0.015275775,0.038238093,0.033792567,0.033342857,0.083777145,-0.0069403723,0.066006884,-0.01945909,0.0002332204,-0.024765145,-0.0031135825,-0.025149606,-0.08292123,-0.09344204,0.018188316,-0.01872053,0.0034603577,-0.102893256,-0.1084261,0.0020066686,0.07538875,-0.047504615,-0.077761695,-0.009517849,-0.021799492,0.013717995,-0.06567361,-0.01889064,0.06595171,-0.04875803,0.0719243,0.046400838,-0.04789317,0.097847305,-0.03595729,-0.16931835,0.0028794697,0.016371908,-0.09203866,0.041174315,0.10129998,0.06320276,0.016561627,-0.05939148,0.038808927,-0.0216076,-0.006989753,-0.050196964,-0.041320648,0.030475227,0.1202049,-0.03821609,0.008523733,0.049584262,0.064340614,-0.00654074,-0.050939366,-0.02583527,0.064474255,-0.016847517,0.023411332,0.01899333,-0.011749955,-0.04045931,0.012171518,0.026224606,0.0039530983,-0.018115325,-0.1303081,-0.012402555,0.015955243,-0.031335633,-0.07939223,-0.047991674,0.042721692,0.020715311,-3.0022704e-33,0.12984756,-0.052453015,-0.0019947097,-0.05670846,-0.035667356,0.012474233,0.028981134,-0.027003912,0.009917459,-0.012729572,0.05795138,-0.047927,0.064887315,-0.026518751,0.02577636,0.03518192,0.005408391,0.06469595,0.04714943,-0.037915125,0.049075615,0.058794882,-0.044012964,0.029096575,0.10176634,0.02882794,0.011230419,-0.007232651,0.005690433,0.055702746,-0.032473274,-0.014290002,-0.0106693255,-0.016473504,0.0016480201,0.07523071,-0.049955074,0.003071336,0.021211429,0.014411446,0.0658515,0.12866984,0.067094386,0.064889394,0.031739566,0.025045667,-0.04869329,0.023297772,-0.06870703,-0.09920619,0.10651227,0.03125319,-0.012386143,-0.067637496,0.039859522,0.044071157,-0.011813861,0.016517768,-0.018158926,-0.013197673,-0.019127822,-0.10288896,0.03568959,0.04285529,0.06959342,0.04992991,0.04752102,0.018793281,-0.02038815,0.06504781,0.029342487,0.015725771,0.023202809,0.06295651,-0.037304483,0.022952165,-0.075656645,0.0267308,0.0363283,-0.046731997,-0.0108338,-0.053663235,0.031980447,-0.072869875,0.008229572,-0.073190056,0.0016742321,0.11090286,0.05813846,9.319689e-05,-0.07343562,-0.011855744,-0.0342454,0.04058676,0.09112782,-4.193458e-08,0.039759945,-0.04573349,-0.03426465,-0.03433352,0.07921767,0.057954274,0.0304014,-0.022305565,0.06334321,-0.05194491,-0.01208181,0.029386755,0.01423775,-0.00592955,-0.035032935,0.10126488,-0.035293248,0.022923918,-0.018745875,0.0050097597,-0.07244767,0.009199411,-0.10443838,0.040341288,0.026498895,-0.04557888,-0.008049016,0.045262836,-0.02468734,-0.08131802,0.021767832,-0.008046185,0.01045185,-0.048388757,-0.051259425,0.047306895,0.005712417,-0.05102508,-0.01744144,0.008161223,-0.047412813,0.018910779,-0.01220557,0.007442749,-0.022196686,0.058004722,-0.018529551,0.009528612,-0.051736757,0.016035145,0.06375097,-0.0046775653,-0.030044835,-0.06795143,-0.14230995,0.002396257,-0.02351676,-0.037203107,-0.021244368,-0.105362676,0.044554733,0.032940675,0.16536972,-0.04379749 +2.7.1.227,"The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long-chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.",384,1.0,-0.07026312,-0.070437945,-0.09267596,-0.034459766,0.021538805,-0.014940551,-0.0026269236,0.02020684,0.046880376,0.021541642,0.06011974,-0.04368535,-0.12861337,0.0071206745,-0.05015584,0.021834988,-0.056865465,0.017864363,0.008697116,-0.014656388,0.032152373,0.0032692682,0.006449826,0.07273477,-0.038626786,0.011346014,0.03657145,0.010190801,-0.0044825585,-0.10234845,0.027145408,0.023568679,0.050200347,-0.06271178,0.0064659175,0.06651307,0.019984331,0.014147963,0.07922246,-0.009617684,0.058940403,-0.027104694,-0.02626437,0.019204672,-0.09634256,0.024991386,-0.05352352,0.048878673,0.07147814,0.03387506,-0.032405093,-0.060965758,-0.077407315,0.012347139,-0.046025526,0.042752583,-0.10209389,0.007154136,-0.031130485,0.08571515,-0.021931821,0.014977815,-0.036556628,0.12462966,0.021297919,-0.07823965,0.027357627,0.008914894,0.017716482,-0.005182645,-0.017200625,-0.08045307,-0.028623858,0.0443645,0.02162086,0.09738015,-0.017037256,-0.04202462,0.030214801,-0.017981013,0.019876894,0.042583536,0.0040217913,0.09318609,0.054330103,0.007954546,0.009659548,0.027204601,0.043280646,0.02149747,0.034264922,0.025397943,0.04240365,-0.037622456,0.010968116,0.08063584,-0.012851533,0.06201757,-0.026482949,-0.00036412405,0.04289293,0.033003815,0.008601067,-0.079171754,0.013867526,0.025451634,-0.029720906,-0.014958132,0.028906396,0.04470182,-0.046598945,-0.041391812,0.02700696,-0.05614431,-0.035067804,0.0062541687,0.019972432,-0.0042446153,0.01771971,-0.089233026,-0.030280368,-0.045546744,-0.026456134,0.014226956,-0.10845789,0.003052333,-0.06192676,2.7243066e-33,0.013419276,0.03502386,-0.009804363,0.022606533,-0.092697784,-0.007971533,0.022181995,-0.066337496,-0.13778934,0.035227258,-0.038937144,-0.058247548,0.0054563717,0.07727262,-0.016669344,-0.037697,-0.008602981,0.0742128,0.09059203,0.06091635,-0.00619005,0.045513645,-0.037396487,-0.04336258,0.054213386,0.08080069,-0.064161606,0.02165713,0.0232826,-0.015266805,0.08931344,0.05106229,-0.070784084,0.030473499,0.01907586,-0.011929866,0.044644497,-0.05239505,0.016604107,0.066126406,-0.09077298,-0.014724228,-0.025553253,-0.028159983,0.030312708,0.026626304,-0.12148087,0.04068874,0.023134049,0.042992096,-0.022370763,-0.0078232745,0.08076453,0.07545207,0.034334157,0.0064685717,-0.05175519,0.02740657,0.027702037,0.076978244,-0.05258684,0.160851,-0.09337303,0.09321959,0.02993656,-0.029882157,-0.061878793,-0.02619938,-0.057244886,0.030559825,0.011458156,-0.029628715,-0.018619416,-0.026533185,0.045318853,-0.056299057,-0.041745078,-0.02933153,-0.083004415,0.040491153,0.04382098,-0.058697246,0.033508025,0.02535211,-0.07364733,-0.009583246,0.02230641,0.031297818,-0.08710658,-0.038128253,0.01682083,-0.08937014,-0.0008751916,0.07512665,-0.03362212,-4.3974616e-33,0.07846404,-0.08044953,0.051084306,-0.1244996,-0.09554413,0.085547276,0.10672888,-0.053231917,-0.0077722087,0.05037511,0.0315017,-0.0017142991,-0.06472755,-0.0435127,-0.024112534,-0.022142425,-0.02097922,-0.013843339,0.027915789,0.023106882,0.027850747,0.07210782,-0.005587194,0.122044444,0.047598526,-0.016214564,0.075372845,0.099346876,-0.03654116,0.018073276,-0.027742662,-0.028715344,-0.02573779,-0.016507557,-0.028087333,0.05041488,-0.07945067,0.015523173,-0.015098799,-0.03216548,-0.026425814,0.040053107,-0.02881758,-0.011007324,0.03738597,0.026374742,-0.08871084,0.091305144,0.00083582,-0.027859522,-0.05316605,0.05541588,0.049632683,0.048347343,0.019535247,0.0031005684,0.0035347762,0.0010985691,0.025323462,-0.098220594,-0.02224641,-0.060965486,0.021539574,0.010031278,0.045833863,0.052315846,-0.006665921,-0.033410978,-0.041227996,0.018508814,0.0008724294,0.03887421,-0.018705826,0.05487891,0.0097371405,-0.043317724,-0.044247683,-0.068571016,0.001770504,0.010436385,0.03228426,0.0008425899,0.034961823,-0.04699842,0.10761895,-0.007902811,-0.009597224,0.051924355,0.031197445,0.053260453,0.058226135,0.04543681,-0.059746798,0.039305586,0.07758678,-3.7472155e-08,0.09330936,-0.07814953,0.047533922,-0.12913148,-0.04377633,-0.008285079,0.034972686,-0.022174068,0.0421909,-0.033980604,-0.027582549,0.1286152,0.054552354,0.09089214,0.09670177,0.008017984,-0.01643864,0.01708884,0.009401063,-0.0762061,-0.03373083,-0.022432944,-0.04668901,0.022044469,-0.03466533,-0.04264744,0.071929164,0.01895361,-0.035666816,0.050261475,-0.020261446,-0.020655647,-0.01570611,-0.021578591,0.045490798,0.07641475,-0.11073286,-0.024352785,-0.047149602,-0.0057358774,-0.06164715,-0.02670278,-0.045345627,-0.0114962505,0.031750597,-0.029577551,-0.02962939,0.039212488,0.070307635,0.011094714,0.0011457492,0.051908676,-0.060545497,-0.090868585,-0.076193206,-0.040677853,-0.08588497,-0.016511433,-0.060097676,-0.040743157,0.0053549437,-0.0095483605,0.13281563,-0.049044915 +2.7.1.228,"This enzyme catalyses the ultimate reaction in the yeast sphingolipid biosynthesis pathway. It transfers a second phosphoinositol group to mannosyl-inositol-phospho-alpha-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C).",384,0.99999994,-0.0440591,-0.052732088,-0.044075407,-0.053771242,0.04207089,0.0028291757,-0.006779865,0.08211838,0.027255235,0.059619606,0.098382115,-0.007914529,-0.09812473,0.025639623,-0.06133874,0.10253695,-0.032871775,0.019126084,0.04758255,-0.008248395,0.054267723,-0.045318063,0.013526852,0.059681408,-0.019470831,0.024444083,0.00951529,0.008459989,-0.022439415,-0.06960071,0.010648172,0.031910963,0.07454266,-0.12327848,0.059139222,0.09590351,0.08341185,0.0043067057,0.052089218,-0.033319864,-0.039701965,-0.08409657,0.008213557,0.054825094,-0.021717561,0.030410951,-0.021982146,0.0804504,0.031609565,0.038678296,-0.023067454,-0.04407748,-0.042379066,0.022915779,-0.02082071,0.02959548,-0.09412149,0.02709308,0.0020611652,-0.028542448,-0.06727655,0.020741083,-0.0007327437,0.094675735,0.0059369863,-0.09049763,-0.013935164,-0.03613213,0.012327364,0.021387424,-0.011839231,-0.10462386,-0.008556711,-0.02079734,0.05196433,0.08765196,0.045031283,-0.027432572,0.08005135,-0.011681121,0.05531211,-0.012686659,0.009161126,-0.0043990617,0.06071718,-0.010684577,-0.016006075,0.03936218,0.087615326,0.03378402,0.0076109837,0.0492408,0.03132973,0.055431064,-0.03134653,0.09757951,-0.056444217,0.065279,-0.009876699,-0.008144989,0.028749947,0.046747282,-0.0009847793,-0.06769548,0.05702554,-0.023584055,0.014406335,0.013545003,0.0019501384,-0.021608178,0.03928358,-0.03135003,-0.005052242,-0.01905489,-0.015157997,0.043947503,-0.0012074113,0.025904318,-0.030257305,-0.056646924,0.0031575053,0.04062243,-0.05000885,0.015568894,-0.14366055,0.03512529,-0.029379983,4.8182125e-33,0.024160843,0.0044664377,0.024120552,0.030970024,-0.05911127,-0.029619982,0.0006016353,-0.06407125,-0.092774175,0.01613327,-0.09788472,-0.0905575,-0.019023813,0.08252595,-0.083736606,-0.015394512,0.0010409561,0.039444346,0.10229389,0.04549401,-0.037393995,0.05659235,-0.036642965,-0.062175326,0.11022207,0.093625076,-0.059524026,-0.007828559,-0.00015496516,-0.010739509,0.024887117,-0.0634895,-0.08505503,0.0071720784,0.005566314,-0.043220043,0.021253787,-0.075088166,0.007579767,0.06250997,-0.11534209,0.012077168,-0.032430097,-0.034085423,0.033295613,0.017806096,-0.04648266,-0.01493012,0.048395734,0.031690765,0.022497127,-0.0156035125,0.071515374,0.12762842,0.017756034,0.012765568,-0.042225625,0.026931295,0.06245451,0.057111215,-0.08161086,0.084027916,-0.03419721,0.02929068,0.039913785,-0.047088817,-0.049128525,-0.0052857865,-0.078000635,0.07549803,-0.019309692,-0.03003695,0.06889584,-0.024032043,0.013921261,-0.08772653,0.027174762,-0.05079559,-0.0612051,0.06042215,0.062363718,-0.034654044,-0.030040158,0.00025098093,-0.019856676,0.08154063,-0.015849242,-0.07496523,-0.036698744,0.018545175,-0.015205034,-0.060916767,-0.005135343,0.06981055,-0.016333878,-5.0020903e-33,0.07973576,-0.07776616,0.09160506,-0.122385874,-0.13743135,0.037510227,0.080585465,-0.095818855,0.053774826,0.029504264,0.0020884802,-0.051174793,-0.004827995,-0.055386014,-0.065036245,0.03496415,0.025902085,0.02608669,0.010778194,0.014987586,0.03921481,0.107195415,0.0031471457,0.089758426,0.022505881,-0.039062865,0.04183247,0.07658995,-0.002112303,0.02179915,-0.03327977,-0.083251216,-0.022039497,-0.045953233,0.026455836,0.023547992,-0.061768334,0.042657223,-0.01068605,0.041033715,-0.044160735,0.023726935,-0.027831078,-0.01575179,0.0054011988,0.07747069,-0.078092255,0.088981144,-0.021485886,-0.0067996527,-0.041454706,0.015964996,-0.025970073,0.06967078,0.035512082,-0.0049540093,-0.006753459,0.029998548,0.00636164,-0.053652212,-0.00015400756,-0.07567378,-0.01641465,0.003790595,0.105055094,0.16618611,-0.021824611,-0.0046506356,-0.06734601,0.047687307,0.013812286,0.006685196,-0.054774396,0.028965343,0.02713948,-0.010026555,-0.06860364,-0.09380701,0.040157016,0.013041522,0.038680412,-0.020073513,0.08109045,-0.03632856,0.037840687,-0.04632041,-0.019229153,0.046216764,0.03485121,0.021213109,0.01846,0.022281114,-0.010775824,0.006403569,0.031887222,-3.6228233e-08,0.02151467,-0.0655163,0.06748864,-0.12391112,-0.033584204,-0.0030787764,0.060281795,-0.018696913,0.009221427,-0.020517947,-0.03353681,0.09473534,0.06896348,0.036674302,0.06055265,0.015238956,-0.008768165,-0.0039471877,0.0018455143,-0.067898646,-0.036714923,0.010392659,-0.03251976,0.01694192,-0.052080907,-0.00202183,0.10365594,0.024218714,0.024727276,-0.014431343,-0.008425579,-0.046204355,-0.0008146161,-0.0028137995,0.00849887,0.05236321,-0.12517247,-0.059151627,-0.03806365,0.0029824402,-0.06600179,-0.03561724,0.03406109,-0.024817199,-0.041963417,-0.0035562445,0.0016228709,0.045251284,0.02629744,0.05021208,0.006601702,-0.004538266,-0.063509904,-0.051117785,-0.08393,-0.041963845,-0.026336493,0.0074103866,-0.00064329116,-0.09453708,-0.008453525,-0.016338026,0.11485297,-0.075289585 +2.7.1.229,"The enzyme, characterized from bacteria, is much more active with 2-deoxy-D-ribose than with D-ribose. cf. EC 2.7.1.15, ribokinase.",384,0.99999994,0.018575557,-0.09010864,-0.0022568267,-0.040271867,0.027196547,-0.04412897,-0.057403695,0.07033748,0.053993642,0.06216218,-0.024020152,-0.037034187,-0.021238653,0.10725316,-0.004162508,0.009026409,0.009408583,-0.026319986,-0.020971933,0.04793354,0.072782844,0.04915808,0.017534984,-0.00088923785,0.054256022,-0.028130881,0.03281413,0.020730834,-0.06292778,-0.034659687,0.0097428,-0.040807948,0.04108803,-0.027372198,0.052999012,0.016166793,-0.004065163,-0.002122412,0.021099227,0.046789,-0.028034415,0.064901896,-0.004032889,-0.02754323,-0.043778867,0.007678099,-0.100988865,0.08754589,0.009730619,-0.021423642,-0.028573727,-0.037046243,-0.08386914,-0.05399935,0.063601166,0.043429434,0.0023634848,-0.03617521,-0.062173348,-0.024944266,0.009982744,0.01897813,0.026452418,0.027179299,0.054019462,-0.08255918,0.06460928,-0.026975466,-0.017757688,-0.0003419575,-0.04358228,-0.056980215,-0.047659684,0.009394516,0.020508606,-0.08853979,-0.010018451,-0.07704698,0.010183835,-0.07465364,0.01664333,-0.045152042,0.016541349,0.0114418315,-0.051562555,0.023276625,-0.0026923749,-0.023190098,0.04127946,0.021072626,0.02211245,0.03933676,0.049383212,-0.029351875,-9.2290305e-05,-0.0385161,0.00887403,0.16228984,-0.021269878,-0.057219937,-0.040349666,0.08767715,-0.06945341,-0.12906204,0.026899233,0.03972305,0.022126328,0.049242795,0.045467377,-0.027119597,0.10433991,0.021044774,0.044321496,0.052102827,0.0015338992,0.08738815,0.051982846,-0.0648931,-0.03237183,-0.025136212,0.024774496,-0.07211867,0.11576426,0.048034456,-0.059203178,0.03958065,-0.030848168,-2.2271693e-33,0.026188308,-0.04121365,0.04807049,0.027008055,0.019172536,0.0019072717,-0.11812613,0.01844328,-0.03545382,0.02648964,-0.19244482,-0.07137232,0.036904097,0.012828439,0.039064728,0.00671409,-0.013532739,-0.022286193,-0.027481642,0.037166316,0.042789802,0.049954064,-0.00029459578,0.038663156,0.07180659,0.0076996787,0.049103547,0.042963788,0.014640496,-0.028778823,0.0066619865,-0.1128033,-0.029877525,0.023074389,0.026736295,-0.0035000935,-0.026334876,0.039881602,0.014022785,-0.029865298,0.016278265,-0.009499112,-0.0019096626,-0.061711382,0.043685414,-0.0008322828,-0.044377837,0.067483276,-0.043146864,0.06747649,0.07686008,-6.65547e-05,0.07042614,-0.062932275,-0.018416654,0.014681809,0.029580299,0.04119601,0.09952196,0.08365356,-0.014883046,0.033101916,-0.034037042,0.029754013,0.015512992,0.061980672,-0.028371386,-0.060436614,0.001943109,0.05943755,-0.04525607,-0.025915796,0.059755255,-0.075202286,0.030841412,-0.062047567,-0.055381622,0.024099587,0.041666068,-0.0018117537,-0.04348656,-0.03356779,-0.101302855,-0.066220134,-0.05362849,0.033540387,-0.0010812966,-0.07951239,-0.016647588,0.116329916,0.026670532,-0.018436054,-0.07539897,0.026098987,0.10206191,-4.5730367e-34,0.0131280795,-0.057975944,-0.015009295,0.003993564,-0.03176225,0.082253896,0.02180687,-0.06563806,0.042508613,-0.12208246,0.09197231,0.06432034,-0.056390353,-0.0031804685,0.0021672414,0.060801398,-0.04105455,0.038795814,-0.055408593,-0.0016732775,0.019835748,0.03310482,-0.06414443,0.0036603382,0.040936835,-0.0013838699,-0.036491327,0.071217045,0.07609701,-0.03771817,0.048097115,0.041309778,0.053903196,0.03303483,-0.11302885,0.08190379,-0.039242502,0.007830106,-0.012794359,0.01542369,-0.10821984,0.069767535,-0.024012677,0.07717581,0.018044999,0.07394041,-0.048531685,-0.08777288,-0.010080557,-0.018062847,0.028461542,-0.05851494,0.041003413,0.037161358,-0.014722136,0.042984072,-0.0017868435,0.07644368,-0.0458587,0.0043169293,-0.012743608,-0.057269983,0.05024138,0.023306075,0.007989461,-0.004236717,-0.06057186,0.04856211,0.034183703,-0.05238807,-0.0066354377,-0.02354167,-0.056092545,0.015757496,-0.044509985,-0.06498886,-0.06493139,-0.0038822745,-0.008902628,-0.01000197,-0.09134325,0.061642654,-0.01860266,-0.017650608,-0.084877566,-0.06364366,0.016612668,0.058609232,-0.011460118,0.06898313,-0.050275538,0.019312207,-0.0012838647,-0.03240853,0.09163861,-3.099938e-08,0.021761922,-0.0024467644,0.04075075,-0.05330285,0.071921445,-0.00237266,0.0073735225,0.05126613,0.041701324,-0.034671076,-0.02409,0.10874042,-0.058973506,-0.013362451,0.05526563,0.009289776,-0.101555705,-0.06864258,0.003290194,0.06672733,0.00045013914,0.031270713,-0.12863348,0.023186546,-0.09088761,-0.032872748,-0.020926842,0.016393617,-0.006065704,0.019615691,0.017006602,0.068381265,0.034006827,-0.06976746,-0.1149188,-0.05137624,-0.052258596,-0.004455776,-0.013755775,0.04501494,0.016983578,-0.08693044,-0.04863379,-0.013214003,-0.04493451,-0.018801117,0.042794544,-0.0024126554,0.023980405,0.02932242,0.06850961,0.02748734,-0.021382991,-0.076992914,-0.068560846,0.057402603,-0.06607271,-0.05669565,0.0058686323,-0.028587725,0.082055464,-0.043225728,0.14450957,-0.036402527 +2.8.1.16,"The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.",384,0.99999994,-0.06320476,-0.06312114,-0.09322818,0.002221116,0.0769474,0.037518412,-0.101792395,0.0026991726,0.040677246,-0.0041264123,-0.026167748,-0.09844339,-0.04843861,-0.0075369156,-0.07898931,0.07935327,-0.085960396,-0.032571368,0.060193405,0.020413093,0.07359153,0.1033899,-0.04870654,0.011377797,0.031098025,-0.010886835,-0.012893787,-0.028789109,-0.01013679,-0.020758172,0.005715418,-0.04660532,0.1134586,2.2228962e-05,0.07763814,0.119951345,-0.005138029,-0.022104107,0.083752915,-0.006836705,0.04988971,0.0061052,0.09680821,-0.0481754,-0.026216604,-0.025743846,-0.010368709,-0.012153026,0.029668124,-0.05832159,-0.069475845,-0.06817568,-0.07181763,0.029891476,0.042160194,0.08247015,0.011694381,-0.05364992,0.008433885,-0.04017903,0.08106528,0.034501813,0.004576369,-0.008273462,-0.014658786,-0.0649126,0.043794844,-0.052985076,0.12770678,-0.028038355,-0.020217927,0.004813859,-0.049012486,-0.021177653,-0.0390341,0.0188857,-0.016003536,-0.051610738,0.020997005,-0.074628726,0.028394727,0.015480111,-0.002772336,0.0029685032,0.05423434,-0.013514004,0.018700548,-0.021929339,0.06377005,-0.049122967,0.012597065,-0.06471881,-0.013913109,-0.10253811,-0.07593691,-0.03735656,0.08869389,0.045466904,-0.0314734,0.017256012,0.009857624,0.04945636,-0.084205054,-0.07393552,-0.09261801,-0.058625966,0.054341245,0.082407825,0.02975044,0.060204934,0.06355182,-0.03995739,0.0681966,0.030420154,-0.04096524,0.07598632,-0.017432343,-0.101022735,-0.039890166,0.045107797,-0.031025985,-0.04209341,0.12085128,0.0018942417,0.014753046,0.052265354,-0.07931541,1.7487679e-33,0.088593334,0.02455661,-0.010113471,-0.04422181,0.060823914,-0.06402525,-0.09380391,-0.013132197,-0.0007164147,-0.05564736,-0.050993245,-0.015357425,0.030973649,0.010864399,-0.057212617,0.03987519,-0.0285387,-0.04470018,-0.00042412608,0.014329424,-0.08214563,-0.0057530594,-0.062083285,0.023891417,0.013019414,-0.048024986,0.017436631,-0.0005065662,0.008861903,0.03416282,-0.024605555,-0.045102373,-0.099037044,0.055743176,0.08828187,0.032143496,-0.03420753,-0.06858034,-0.003236538,-0.0069545056,0.06903663,0.035263866,0.0152451815,-0.033803694,0.052203145,0.060834806,-0.018349402,0.1100899,0.031006398,0.043541312,-0.013357795,-0.021883002,0.08937545,-0.016179834,-0.10426724,0.010367307,-0.050059333,-0.051163845,0.07091404,0.063685894,-0.038569007,0.0139649045,0.0065339766,0.1055133,-0.01978074,0.02884023,-0.033251483,0.0009702312,0.09102745,0.0958748,-0.030388871,-0.07044952,0.02026513,0.10356039,-0.025564006,-0.030559573,0.0010657816,-0.021961134,-0.00048960693,-0.004573577,0.050743617,-0.041412078,0.009092222,-0.0021013976,-0.00942731,0.021760676,0.0003356483,-0.022394104,-0.0038628757,0.02092437,0.018604076,-0.038659945,-0.010162956,0.03658158,-0.027498374,-3.200013e-33,0.055962067,-0.08192778,0.04187371,-0.12773183,-0.08048402,0.08063475,-0.034934975,-0.040750712,0.044460576,-0.040062923,0.124631844,0.00026000082,0.028111927,-0.060487147,0.0579743,-0.07572959,0.044758964,0.014537967,0.051986862,0.051000096,0.0657091,-0.0214274,-0.0450716,-0.047970466,0.05203756,-0.0033769214,-0.0047738748,0.054266755,-0.019524394,0.02368972,0.0039377725,0.035816573,-0.051485565,-0.03132184,-0.13441001,0.03449767,-0.028390836,-0.04070415,-0.0076419315,0.00054531824,0.051303726,0.072552666,0.0046963226,0.033380527,0.07267169,0.020802513,-0.06897941,-0.0205422,-0.02463849,-0.119757555,0.019134207,-0.09187159,0.039965767,-0.045646984,-0.009972009,0.0765124,-0.051827207,0.063748024,0.0016652453,-0.027309457,-0.02193182,-0.049080312,0.008117538,0.0025864667,0.03176524,0.0037058734,0.016266452,0.050509468,-0.033683356,-0.022828752,0.03483177,0.043928027,0.05163552,0.13442412,-0.024455775,-0.036501337,-0.09126949,-0.036128618,0.020072013,-0.06422451,-0.029927876,0.0040164245,0.046496022,-0.0597327,-0.032472577,-0.06013373,0.05165651,0.07729888,-0.015319274,0.054676212,-0.06405067,-0.0076833824,-0.055251136,-0.015008754,0.02116024,-2.8495903e-08,0.07681476,0.014177576,0.07121335,-0.03066782,-0.04052293,0.02287003,0.038060676,0.030751457,0.052920077,-0.048343528,-0.008823405,0.05788427,0.04921038,0.025072172,-0.00560558,0.07163842,-0.030348392,-0.012916218,-0.06801165,0.033474375,-0.0061275647,0.0004639704,-0.0046087583,-6.988077e-05,-0.00880531,-0.041989435,0.033528473,0.094239146,-0.06374948,-0.03901667,-0.02326157,-0.00091224007,0.02443366,-0.044112213,-0.077189535,0.02639242,-0.04796145,-0.09476617,-0.00091183925,-0.023486987,0.03696443,0.021373194,-0.06603787,0.016606329,0.011422773,-0.014538098,-0.017023543,0.060438,-0.020431371,0.030649075,0.047470115,-0.011871662,0.03966303,-0.05589755,-0.048206165,-0.08106831,0.007964517,-0.027896453,-0.050925117,-0.00056070765,0.103711694,0.0060380297,0.13387069,-0.010897216 +3.1.1.110,"The enzyme, found in bacteria, participates in the degradation of D-xylose. cf. EC 3.1.1.68, xylono-1,4-lactonase.",384,1.0,-0.021658191,-0.08566766,-0.0031045433,-0.025734344,0.06632553,0.017057907,0.0060843476,0.072104864,0.0048442995,0.016094273,0.012665411,-0.014351808,-0.057535805,0.09400291,-0.025766242,0.03598563,-0.065938234,0.022492018,-0.04180435,0.03794245,0.094563685,0.04461193,0.02757941,0.00993933,0.09734284,-0.07441777,0.055374604,-0.063872255,-0.026096191,-0.029667586,-0.013560043,-0.09560394,0.09963865,-0.020889804,0.10425685,0.043410018,0.08495844,-0.08301355,0.03728411,-0.017038275,0.033886377,0.005019509,0.012850946,-0.041520044,-0.06897411,0.015269413,-0.032460168,0.05704272,-0.002000265,-0.010525153,-0.031500466,-0.060664017,-0.024648149,0.0138101345,0.07221227,-0.003536682,0.0055747256,-0.029309258,-0.08800681,0.0065870816,0.105856255,0.110377446,0.042751227,0.02711485,-0.00788325,-0.07684643,0.060042664,-0.0407058,0.015056428,-0.013572605,-0.072943814,-0.07631262,-0.04213925,-0.027784992,0.0103793405,-0.020620182,0.051008746,-0.104235955,0.038562857,-0.0646787,0.050542414,-0.0038437361,0.018783322,0.056974687,-0.021795595,-0.031922504,0.055991694,-0.031309947,0.020766018,0.02741701,-0.004631611,-0.011333665,-0.05871173,-0.06478945,-0.03100427,0.0066295736,0.0821753,0.05279368,0.07205563,-0.023831215,-0.062333364,0.037650608,-0.0072037014,-0.07491077,-0.07866757,-0.003316685,-0.009512401,0.0690386,-0.0014098191,-0.02784005,0.016776893,-0.023249885,0.028541896,0.10798674,-0.07108742,0.046192337,0.06144373,-0.030271308,-0.10683189,0.021219669,-0.02115066,-0.06075523,0.05176229,0.09665156,-0.019160537,0.025509631,0.0044602365,-4.0830642e-33,0.046566017,0.019477328,-0.059367415,-0.07817398,0.03144726,-0.038064502,-0.034370407,0.06840962,-0.109178044,0.0029163484,-0.013106697,-0.11201963,0.01796454,0.0041466733,0.011431364,-0.006119073,0.0136494525,-0.0073726005,0.025689458,0.030372685,0.026622301,0.013937623,-0.030041903,0.015586458,0.01132156,0.04770693,0.01621327,0.08745013,0.010779769,-0.022507548,-0.021463996,-0.122625865,-0.06700394,0.077948116,0.02125229,0.037801534,-0.03890607,-0.019996243,-0.0019408412,0.011813198,-0.027331349,0.011490578,0.004955742,-0.074904956,0.0025432562,-0.025460588,-0.040722206,0.03620708,0.035385992,0.00485763,0.046222445,-0.032502886,0.029609716,0.02410774,0.0058369962,0.018946508,-0.021279795,0.011817478,0.025857108,-0.027506184,0.041485332,0.005348785,-0.04464704,0.02817058,0.07576078,0.011219314,0.012630397,-0.05417267,-0.011268424,-0.0020071862,-0.1478912,-0.1198231,0.029621668,-0.0481814,0.068257414,-0.031044492,-0.0834515,0.04602586,0.03934276,-0.04363771,0.017213928,-0.0523815,-0.020638548,-0.016284773,-0.069933124,0.015363686,-0.03845737,-0.03084942,0.0058182334,0.05566892,0.021510314,-0.08941784,-0.059261195,0.05276044,0.023454687,1.37145165e-33,0.020096613,-0.016594293,0.017205203,-0.010961677,-0.070490696,0.058022752,-0.01581181,0.05596326,0.0054553635,-0.072024934,0.06794551,-0.002971136,-0.025938217,-0.007862551,-0.006905362,0.11497704,0.052979793,0.0018079594,-0.059063967,-0.043098763,0.060603097,0.09299938,-0.0495589,-0.0033157684,0.041487567,0.010403945,-0.0017311785,0.07863376,0.06396822,-0.015002553,0.023270868,0.00097454304,0.026018187,-0.03419533,-0.08832762,-0.013648823,-0.037465382,0.010581961,0.007742694,0.046689242,0.04190515,0.05849483,0.0513824,0.07726699,0.040179387,0.10346852,-0.073164456,-0.0011986858,0.05143655,0.024065847,0.012873504,-0.012141679,0.018923711,-0.018394632,-0.024295138,0.11407863,0.036006056,0.066480346,-0.05964762,0.007210966,-0.0691405,-0.054020118,0.0870934,0.04508918,0.054808274,-0.016689938,-0.06786274,0.06444741,0.03603979,-0.07965751,0.087002054,0.04100131,-0.05462092,0.0017262321,-0.11834435,-0.02631967,-0.1339533,-0.07095848,0.013920109,-0.00035582227,0.04375049,0.010863929,0.0046955473,-0.032596227,-0.008875849,-0.05280072,-0.00806646,0.1322348,0.011627477,-0.01464288,-0.020226115,-0.04034633,-0.07772143,-0.01386336,0.09983202,-2.7331483e-08,0.013795083,-0.04005499,-0.0017712824,-0.040138274,0.017705342,-0.019057406,0.027841963,0.0921166,0.09237591,-0.026165616,-0.058250584,0.0880047,-0.038163632,-0.013353731,0.012270949,-0.029638978,-0.027056519,-0.04129143,-0.047988098,0.026412178,-0.025572926,-0.063614056,-0.09530026,-0.0027898776,-0.018823529,-0.06845745,0.05353622,0.09447226,-0.058080595,-0.028691545,-0.0313133,0.09428811,0.03256049,0.023345424,-0.07914625,0.026932335,-0.08240076,-0.0725506,0.023067527,0.043909956,0.032656267,-0.011966686,-0.037610073,0.01876461,0.012789523,0.03238892,0.030380817,0.0074005565,0.004705683,-0.008376992,0.03008061,0.004362145,-0.063868344,-0.05582213,-0.059157427,0.04468612,-0.009125492,0.011517471,-0.003102756,-0.034710515,0.025287734,-0.015012829,0.19163465,-0.082865186 +3.1.1.111,"The enzyme, which has been described from mammals, is specific for phosphatidylserine and 2-lysophosphatidylserine, and does not act on phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid or phosphatidylinositol.",384,0.99999994,-0.022344407,-0.10709086,-0.055310212,-0.04983605,0.030620277,0.006069311,-0.05968304,-0.00043985163,0.012502317,0.036833517,-0.015166311,-0.029280132,-0.086308524,0.0982056,-0.007673777,0.05989039,-0.057715025,-0.04639783,0.039708827,-0.018748036,0.079712406,-0.0076375916,-0.011391233,0.015005901,-0.021860296,-0.030948265,0.0070739547,-0.019642364,-0.03529253,-0.05227355,-0.05820553,-0.06373619,0.022328224,-0.043424856,0.031954072,0.041930128,-0.053054344,-0.03669897,0.040562548,0.0128870495,0.08069437,-0.046202213,-0.05360714,0.0052355616,-0.041675664,-0.008667931,-0.03703801,0.0048928917,0.0039768005,0.030165028,-0.022278387,-0.08496091,-0.081648245,0.03948904,-0.10739898,0.07424471,-0.060596712,0.0803794,-0.021656964,0.03362409,-0.06569863,0.0687678,0.039438654,0.054787926,0.04079426,-0.02005816,-0.0073237997,-0.07843593,0.02200799,-0.03894733,-0.030288994,-0.08824112,0.052225247,0.053851444,0.040005263,0.023186667,0.028050197,0.016178718,0.03978074,-0.08543566,-0.023500282,-0.0678671,-0.02673093,0.06375705,0.03006074,0.044476345,-0.081112415,0.01803747,0.011910778,0.006800512,0.019415429,-0.11498846,-1.1117744e-05,-0.029373225,-0.012213214,0.029688625,-0.018212514,0.009369279,-0.016544934,-0.06096535,8.786479e-05,-0.00028272232,-0.04969544,-0.048504207,-0.021188382,0.059554182,-0.023503695,-0.09934262,-0.017146913,-0.04353286,-0.008724176,0.047180872,0.08541656,0.018755687,0.054558538,0.023555677,0.0064086746,-0.06795432,0.029680457,-0.01422152,0.0036209882,-0.06746658,0.031291682,0.02527181,-0.02561895,0.07664962,-0.09572071,7.2398815e-33,0.009487848,-0.033670492,0.021118443,-0.06607087,-0.01879097,0.040115237,0.002958976,0.06430408,-0.04801693,0.0013918803,-0.036541406,-0.08151944,0.08107549,0.03711001,-0.00048581293,0.036321554,0.044435382,-0.0013170864,0.08035028,0.008616882,0.0156076895,0.05951485,-0.05442415,0.057195716,0.038323447,0.052591648,-0.089594625,-0.018106157,0.04289995,0.010764403,-0.00015963199,-0.13169125,-0.10774126,0.035000917,-0.00086168956,0.019994669,-0.013088896,-0.059686016,-0.015223915,-0.0034385927,-0.024243504,-0.011644316,-0.016619276,0.01280065,-0.006218742,-0.020579465,-0.06588242,0.07544162,0.05649897,0.010147001,0.024975356,-0.065845884,0.108806044,-0.020880613,-0.017168421,0.063411154,-0.0067444327,-0.06573928,0.0047706515,-0.004656777,0.045532722,0.013966853,-0.056670196,-0.009811626,0.040486872,0.047990754,-0.01913262,-0.079008535,-0.07968385,0.11636094,-0.03714212,0.013956995,-0.029027605,0.013937272,0.031828627,-0.064738765,0.04421763,0.045513835,-0.014825617,0.030163765,0.07034373,-0.032907397,0.06520265,0.020041512,-0.033840116,-0.026193704,0.055928607,-0.0049041407,-0.028933583,-0.012505687,0.034024835,-0.06435998,-0.03040542,0.07314986,0.015033389,-9.3574794e-33,0.0031938958,-0.07505817,0.06910284,-0.050778832,-0.06426765,0.09303282,0.040592056,-0.033868287,0.090627775,0.020579502,0.07941739,-0.032199915,0.009488461,-0.049940187,0.03764276,0.026258871,-0.1046087,0.013428019,0.0876741,-0.031572014,-0.09513405,0.07258508,-0.047847882,0.053762686,0.10794762,-0.055320676,-0.07525036,0.076257676,-0.028887216,0.019498577,-0.06534923,0.037742045,-0.02044425,-0.068358175,-0.005634441,0.01670903,-0.07626363,-0.043326966,0.0070444513,-0.009360958,0.0018369409,0.035011273,0.10580427,0.050150655,-0.007136287,0.075490445,-0.061344944,0.057230342,-0.03948537,0.013553681,-0.03738317,0.029435115,-0.018051215,0.051961202,0.018408706,0.1083556,-0.033836715,0.032327145,-0.03076957,-0.10137384,-0.013693715,-0.084440276,-0.059359264,0.07887031,0.031646077,0.028091881,-0.02750484,-0.0032817477,0.024753632,-0.013504233,0.06963365,0.033186667,0.03356189,0.050197132,-0.042270962,-0.00036669042,-0.06552776,-0.049239084,0.053149924,-0.024852036,0.06006765,0.07503873,0.044137694,-0.058836486,0.029152378,-0.02698309,-0.037265938,0.14184256,0.021125805,0.026232783,0.0069786385,-0.02533562,-0.043297704,-0.031352673,0.06354997,-4.797357e-08,0.072812945,-0.004576746,0.017994491,-0.09778049,-0.032553047,-0.028674722,0.033583958,-0.053857815,-0.010492835,0.034962844,-0.074775115,0.03167438,-0.015837325,0.038282726,0.053661007,0.00798517,-0.0135059245,0.08911713,-0.0081691835,0.045278687,-0.01460581,-0.0021114736,-0.11890634,0.054413,0.025818035,-0.028596682,0.034933392,0.020502118,-0.02284882,0.0040018857,-0.023148803,0.01906136,0.0033909536,-0.10927996,-0.060763378,0.053970844,-0.023026273,-0.044824176,-0.06787868,0.049585707,0.0035528897,-0.036545828,0.0188391,-0.025743099,0.0035187812,-0.007580164,0.08102963,-0.058445614,0.047200136,-0.03820256,-0.020358272,-0.03803832,-0.02491342,-0.07863837,-0.07432969,-0.041698776,-0.03277535,-0.054237023,-0.016772129,-0.06958902,0.027556367,0.09900438,0.23377176,-0.036856826 +3.1.1.112,"The enzyme, characterized from the yeast Saccharomyces cerevisiae, hydrolyses acetate esters. It acts preferentially on 3-methylbutyl acetate, a major determinant of sake flavor.",384,1.0,-0.030882476,-0.0724974,-0.08188262,0.00929887,0.01677297,0.066806264,-0.02389017,-0.0041123056,0.04718514,-0.04687637,0.0008921082,-0.06609833,-0.12607792,-0.018256765,-0.045837365,0.037786536,-0.043309163,-0.068869814,0.018588474,-0.081860475,0.07796525,0.011834157,0.0074136895,0.02424745,0.055001605,0.01999422,0.02786953,0.023076573,0.037098,-0.12783049,0.018094972,-0.013205901,0.06875815,-0.018194454,-0.015827388,0.121945895,0.011410688,-0.07909175,0.063322626,-0.0050773434,0.06719655,-0.008448102,-0.084404096,-0.01628321,-0.039473604,0.059731618,-0.023608064,-0.005007936,0.023071695,-0.034880202,-0.032387864,-0.09043988,-0.009190522,0.006846084,-0.023167158,-0.07097986,0.009153076,0.012507549,-0.021983195,0.07606522,-0.033549927,0.024657365,-0.032297697,0.032566715,-0.010088769,-0.052878127,0.055917125,0.0068551074,-0.033834234,-0.03272843,-0.053672206,-0.08079051,-0.06732049,0.015253519,0.026606357,-0.047766294,0.022553297,-0.09252649,0.038305882,-0.022036,0.021832831,-0.021347282,-0.016637484,0.073864855,0.054114282,-0.04657326,0.005412794,-0.0052369214,0.13224916,0.060412116,-0.0333668,-0.02364166,-0.0064945347,-0.0032116044,0.031647746,0.09554604,0.012533077,-0.010599302,0.020637996,0.01075559,0.031830534,0.0988199,-0.0037516744,-0.052413136,0.025693681,0.036976267,0.0063588815,0.103525855,0.0562651,0.013907375,-0.051508017,-0.0033100573,0.016768781,-0.07594071,-0.09798152,-0.022825552,-0.016273541,-0.032972682,-0.030669171,-0.10979204,0.031198572,0.019575236,0.07719879,0.050117277,-0.05452305,0.036404945,-0.06290889,1.9595213e-33,0.027819172,0.00078030414,-0.06801868,-0.009197488,-0.041708644,-0.039101757,-0.06573459,0.08039784,-0.018888725,-0.027410401,-0.02389514,-0.044452157,-0.06566907,0.07682314,0.04097344,-0.029130952,0.01984953,0.005778619,0.048940044,-0.0055611413,-0.06573405,0.035802558,-0.08465063,-0.00080719194,-0.028859377,-0.011096498,0.01773462,0.06497252,-0.0071006087,-0.040244203,0.05777396,-0.078740306,-0.07711531,0.0013979594,0.0519774,0.022804514,-0.014820142,-0.00199156,0.010460053,0.05247899,0.040234927,0.025079593,0.042746376,-0.028439652,-0.05411296,0.042443555,-0.053811096,0.036218736,0.080108315,0.03448689,0.02400215,0.0014280855,0.12147563,0.068711534,-0.022080034,0.07055869,-0.046895,0.0056349984,0.0025244486,-0.003759196,-0.09260298,0.030986415,0.01686477,0.058560368,-0.07099377,-0.016158259,-0.028368635,-0.024619067,0.035436198,0.07906296,-0.09794579,0.013317802,0.043354873,-0.015545131,0.013847488,-0.07622423,-0.041274622,-0.007716108,0.02453969,0.032499455,-0.032657214,-0.046323754,-0.004147723,0.022101698,-0.11718135,0.039613962,-0.020714097,-0.02622411,-0.0009265104,-0.0030357342,-0.019023834,0.003563736,0.04855193,0.05527397,0.012350853,-4.6698416e-33,0.08271787,-0.12529607,0.10055528,-0.10282939,-0.06598568,0.07483021,0.042585876,-0.0028547018,-0.062808864,0.0040802406,0.056313172,0.006648382,0.037246753,-0.06433162,-0.020443931,0.062326632,-0.0045811376,0.064372346,-0.030782402,-0.00402435,0.014807754,0.1315597,0.002001918,0.013082547,0.038947448,0.027263744,0.03643299,0.05717824,0.03493267,0.036653664,0.039896794,-0.06953846,0.055397782,-0.03791864,-0.025383592,0.080009826,0.016319789,-0.018315483,-0.104299165,0.064679794,0.048387904,0.10362302,-0.04171018,0.05647669,0.05026325,0.12248834,-0.04712121,-0.011970235,0.012714146,-0.038750764,0.0377677,-0.0017867564,-0.022642488,0.043983057,0.034427408,-0.022296537,-0.050388575,-0.025992652,-0.04063103,-0.06721956,-0.06255964,-0.034963053,0.03708996,-0.062675655,0.02018056,0.037620667,-0.053229894,-0.05544004,0.008374822,0.0025213496,0.042296957,-0.0056690583,-0.008561593,0.059926134,-0.018432204,-0.0424404,-0.09171414,-0.06254914,-0.0606356,-0.05023383,0.03948013,0.00095851487,-0.026735473,-0.042903442,-0.106640175,-0.060659535,-0.003673327,0.053064544,-0.025660101,0.048102237,-0.009499568,0.05749306,-0.075922735,0.07983908,0.03410956,-3.6283616e-08,-0.010260073,-0.06494358,0.071780205,-0.052287873,-0.01892596,0.039744828,0.0356027,-0.01701578,0.019634252,-0.024899157,-0.07214457,0.12295271,-0.04685727,0.03321491,0.021246634,-0.058350418,-0.06822594,0.073521465,-0.0010899209,0.01017308,-0.021169744,0.016816564,-0.036750056,0.004182221,-0.015584206,-0.059352435,0.0124733215,0.05514045,0.039742216,0.011596736,0.029983211,0.09536871,0.036108077,-0.061304614,-0.04051344,0.10232683,-0.045062974,-0.084776975,-0.053600162,0.08166793,0.015213823,-0.0058961282,-0.07635823,0.023330301,-0.0315383,-0.019730384,0.029267833,0.033125073,0.027481604,0.017771995,0.06741523,0.027761616,-0.017976563,-0.0052532037,-0.051332068,-0.031159727,-0.08793367,-0.073189594,-0.006598049,-0.052293375,0.09021875,-0.01571389,0.1762296,-0.03907727 +3.1.1.113,"The enzyme, characterized from Pseudomonas strains, is involved in degradation of short chain alkyl methyl ketones.",384,1.0,-0.031047551,-0.008042583,-0.019901752,-0.021923555,0.02174145,0.041340653,-0.15026988,0.004650762,-0.0033832793,-0.04469529,0.04703712,-0.027295286,-0.05739391,0.03903016,-0.07045436,0.09151841,-0.06902297,0.0006637392,-0.03190609,0.05641031,0.07202536,0.04983977,-0.091164835,0.0429225,0.007095138,0.059477072,0.078861125,0.031591777,0.009791438,-0.04346052,-0.04529522,0.010391669,0.091783255,-0.027030446,0.10754246,0.1190378,-0.035509977,-0.025042547,0.10481262,-0.0089903455,0.04467474,-0.0041357884,-0.04138971,-0.039112605,-0.02350476,0.0028275442,-0.012319527,0.001486801,0.029573834,-0.057056252,-0.044344895,-0.048631307,0.060220547,0.044484057,0.015487009,-0.021169769,-0.02356108,-0.04268818,-0.06252345,0.046781335,0.03654769,-0.010952226,-0.064317286,-0.0062443083,-0.005526244,-0.05351006,0.062019024,-0.054072473,0.061218653,0.013092193,-0.12344418,-0.07289522,0.019711517,0.073079385,-0.0037511808,-0.05099449,-0.0050694696,-0.10905274,0.0056646354,-0.062038627,0.025599169,-0.017198734,0.028230602,-0.015167293,0.043666784,-0.036591105,0.016948333,-0.006740793,0.05177279,0.021005427,0.0017233591,0.0007344479,0.0015256344,-0.081707865,-0.01421288,0.06754927,0.01871079,0.03707569,0.016735395,-0.0042485637,0.025411433,0.0052849837,-0.035034716,-0.078973405,0.0055948673,0.009047275,0.06569522,0.079467334,0.026872637,0.0012828002,0.014754525,0.03241814,0.009761098,-0.04148898,0.0024630155,0.043898754,0.060717702,-0.04531714,-0.054011427,0.049965672,-0.027435863,-0.047779243,0.051565778,0.07377825,-0.042335838,0.01715329,-0.08154185,-1.3889541e-33,0.0056846915,0.009592103,-0.033579294,-0.105529614,0.020132205,-0.07840762,-0.061211947,-0.019631078,0.0075139534,-0.11762414,0.033297226,-0.025291951,-0.011216622,-0.03252672,-0.02190618,0.010478633,-0.020573001,0.026489284,0.033692952,0.0025859312,-0.020661647,-0.0067812717,-0.05068276,0.011804356,0.045219354,0.0171005,0.04291795,0.0048825196,-0.044177484,-0.017694598,0.007047327,0.016674548,-0.13639663,-0.007998477,0.039166324,0.04109137,0.015314405,0.022475312,0.014757325,0.08393655,0.016800212,0.012195456,0.014844843,-0.0065673217,0.00943357,-0.026689027,-0.067579165,0.13712493,0.021027254,0.041098487,0.06914856,-0.081116036,0.010454605,-0.0034095086,-0.0624882,0.028079126,0.0051401802,-0.0642645,0.018480137,0.010848328,-0.012628669,0.0041516433,-0.024629245,0.044556126,-0.0025568514,-0.09441669,-0.08089206,0.011683569,0.011020682,0.021380832,-0.08655622,0.017972475,0.041371115,0.021810716,-0.041975904,-0.05911476,-0.11406247,-0.009281379,0.002538583,0.07813611,0.0033228963,-0.03613781,-0.0012852012,-0.07864699,-0.10779759,0.03293407,0.039838083,-0.06268798,0.009395405,-0.038300052,0.024721278,-0.09214043,-0.04877076,0.0710999,-0.007006791,-1.3057421e-33,0.098080784,-0.032434873,0.09280724,-0.0056914836,-0.032877028,0.04254585,0.008063279,0.103855245,-0.039857622,-0.027973646,0.06785633,0.032889917,0.044295114,0.027675021,0.045309342,0.063711144,-0.01352978,0.0024276534,0.0031624206,-0.05325502,0.0029554435,0.07394211,-0.09962809,0.076666914,0.028061267,0.046975203,-0.08560359,0.110941716,0.08037673,0.057016294,0.010004418,0.019295322,-0.033114213,-0.01514399,0.06815314,0.09857849,-0.034660783,0.021328857,0.021461153,-0.013207481,0.050121307,0.018296514,-0.048021503,0.023280876,-0.0048981644,0.078769825,0.0076151597,-0.021289378,0.0497318,-0.13300325,0.049606785,0.01970124,-0.019929945,0.050569963,-0.073812336,0.040622007,-0.05606075,0.04125336,-0.055860378,-0.013399427,-0.082756415,-0.094826676,0.049883623,-0.013010018,-0.010078868,0.012631517,0.038099017,0.045763236,-0.0045651924,0.011918993,0.035694133,0.09737773,0.01053011,0.039857704,-0.08564814,-0.0315634,-0.07832266,-0.043672185,-0.058016527,-0.003483275,0.08472283,-0.013010273,-0.041281544,-0.0668302,-0.03647164,-0.043022268,0.03682122,0.08048445,-0.076619655,-0.0043659387,0.040434603,-0.020151623,-0.07373464,0.060365923,0.007827274,-2.4458602e-08,0.074369244,-0.07824118,0.06464316,-0.028722653,0.046326403,0.07597842,0.01296751,0.028213147,0.08537848,-0.0144192185,-0.10367307,0.029250244,-0.039167326,0.06743572,-0.051922422,0.0036995152,-0.10262045,0.0019227904,0.026498552,-0.05459606,-0.07706874,-0.040807247,-0.042838696,0.03155375,-0.04609694,0.02881582,0.064471185,0.08988016,-0.014232528,-0.031636473,-0.03188766,0.096511304,0.022893058,0.039472688,-0.07222146,0.031194564,-0.005903627,-0.034401774,-0.051810894,0.0423566,0.00948644,-0.010087316,-0.11631869,-0.027407082,0.036301143,-0.022157982,0.029047532,0.023603627,0.032880135,-0.03579681,0.099468954,0.012489126,-0.020889528,0.011275586,-0.07698097,-0.006748315,-0.038851164,0.00837774,-0.05252463,-0.030678572,0.030098582,-0.01173207,0.14569451,-0.06366062 +3.1.1.114,"The enzyme, characterized from the bacterium Gordonia sp. TY-5, participates in a propane utilization pathway.",384,1.0,-0.08190225,-0.01586015,-0.09688625,0.015125853,0.08633098,0.021169689,-0.001612024,0.014514659,0.04008009,0.015215032,-0.023563238,0.0014013053,-0.10950852,0.027716212,-0.026817864,0.01134533,0.003905421,-0.049679473,-0.01558596,-0.098796256,0.069687575,0.055571523,0.046150528,0.015557974,-0.012704424,0.009367226,-0.010320796,0.016585993,-0.022016698,-0.0185223,-0.057008363,0.027233284,-0.027959596,-0.08062238,0.066164576,0.09272763,-0.054830503,-0.013955733,0.05533089,0.040864266,0.08279959,-0.098485306,-0.029914891,-0.023711279,-0.006167586,0.016785577,-0.027776534,0.0934516,0.03493475,-0.10756199,-0.07425013,-0.06544946,0.012350942,-0.03881247,0.03489265,-0.017910369,-0.0009419199,-0.071599245,-0.012459325,-0.107011504,0.0527402,0.029427601,-0.017817747,0.011872484,-0.068500504,-0.04168214,0.054291178,-0.05639947,0.043450717,-0.060523972,-0.081465065,-0.08179718,-0.01932347,-0.0021573948,-0.049111575,-0.023269352,-0.0014931281,-0.05661884,0.10357746,-0.048927277,0.011190541,0.035813726,0.028463136,0.027214741,-0.021344457,0.002740855,0.02310921,0.030282151,0.052664187,0.020835977,-0.0052696425,-0.030039625,0.01752474,-0.07340492,-0.06311605,-0.0049539404,0.034979686,-0.02854074,0.049451526,-0.040858176,-0.029402332,0.06961235,-0.037653074,-0.059672907,-0.076608695,0.035037395,0.007261631,0.1350487,0.080920674,-0.04105022,-0.004074006,0.008194299,0.059643917,-0.012628201,-0.0072270273,-0.008596934,-0.020923292,-0.007337153,-0.010091043,0.05116469,-0.020722691,0.007015909,0.02550265,0.050088294,-0.0556016,0.039617475,-0.089501575,-3.8187932e-33,0.031680807,-0.031762082,-0.00022680618,0.0191836,0.06484876,-0.009917699,-0.042879645,-0.005774926,-0.04686391,-0.011593289,-0.07162377,-0.08740156,-0.030730639,0.0082739275,-0.046530236,0.030747037,-0.034626752,0.039006654,0.018224757,0.016855156,-0.020912798,0.05368679,-0.022775702,-0.016172264,0.05084643,0.04701378,0.001838469,-0.020236636,0.005396882,-0.0062254528,0.027280258,-0.06569292,-0.12618901,-0.010740689,0.09817129,-0.009192717,0.051759273,-0.016356668,-0.11704955,-0.015435121,-0.03964254,0.07955584,0.016650656,-0.026148044,-0.019718474,-0.012431578,-0.013437298,0.10728867,0.041550323,0.05671618,0.048740007,-0.021734184,0.1104446,-0.020137277,-0.082148015,0.06417624,0.017640283,0.040668435,0.039433356,-0.02090176,-0.034665257,0.08375745,-0.061524987,0.0112807555,0.026625,0.027683951,-0.02140781,0.0010677717,0.045945875,0.15660211,-0.036179315,0.030871363,0.025261573,0.03296508,0.056949854,0.0073771277,-0.0357281,-0.044812948,-0.023543257,0.006650024,-0.062416986,-0.110348515,0.06472296,0.022807054,-0.08655514,-0.0010491319,0.0036011238,-0.0553519,0.01047928,0.0140692415,0.08314343,-0.09865151,-0.018537203,0.086410865,-0.006540015,1.8385248e-33,0.11018001,-0.072222,0.032718953,-0.05561432,-0.06635864,0.051188823,-0.049552195,-0.11228214,-0.0073123546,-0.01773235,0.105717726,0.047834743,0.04747567,-0.0010060361,0.043667737,-0.050572183,-0.0097090695,0.05672945,-0.05517608,0.016330102,-0.04895149,0.013058249,-0.019969504,-0.024666915,0.024901321,0.011274188,-0.037858468,0.083215564,-0.04579386,0.021469377,0.050663963,0.028427655,-0.03464031,-0.06311623,-0.020505924,0.051444314,-0.026022855,0.015770286,0.026188523,0.026354477,0.00078759005,0.005031546,0.024334332,0.080463484,-0.047532275,0.08460122,0.018615635,-0.016660582,0.01496077,0.021417258,0.07424565,-0.023110004,-0.049080346,-0.0024994432,-0.01776407,0.05654969,0.068081856,0.031918038,-0.05534548,-0.023981204,0.012408821,-0.031207155,0.093786314,0.0762416,0.035443876,0.051571194,-0.0125556225,0.035088178,0.1175127,-0.018193517,0.011165751,0.039610922,0.0653737,0.08952796,-0.039771013,-0.039522048,-0.032121245,-0.041939493,0.048553705,0.012914639,-0.0048819454,-0.026351437,-0.060913935,-0.10192327,-0.014399925,-0.10192099,0.028234234,0.08073554,0.05360492,0.09530854,-0.008529041,0.031961426,-0.09198312,0.020881439,0.02113836,-2.3022121e-08,0.0063222433,-0.029982487,0.06590462,0.011073783,-0.011833549,-0.0020386353,0.04074567,0.04491739,0.056859598,0.0015165549,0.02694776,0.049677875,0.024640162,-0.021277504,0.010393016,-0.021492418,-0.07729597,-0.026238259,-0.011134326,-0.06093393,-0.038002048,-0.050686583,-0.08989985,-0.007176803,0.061564304,-0.120898575,0.04588465,0.07212839,0.055867106,-0.054649975,-0.023223877,0.060569957,-0.030474164,0.007957291,-0.068416975,0.045490798,-0.04830464,0.005284568,-0.036016323,0.066684045,0.0029058473,-0.018902604,-0.12273902,-0.035029724,-0.012299496,0.032480262,-0.047967356,0.09233887,-0.024651123,-0.013334162,0.06395571,0.016017035,0.049783077,0.081170484,-0.10392901,0.009164455,0.025495362,-0.005220007,0.018032964,-0.0637106,-0.0052599786,0.026402073,0.13895299,-0.09839678 +3.2.1.210,"In yeast this activity is catalysed by a dedicated enzyme that processes unfolded protein-bound Man8GlcNAc2 N-glycans within the endoplasmic reticulum to Man7GlcNAc2. The exposed alpha-1,6-linked mannose residue in the product enables the recognition by the YOS9 lectin, targeting the proteins for degradation. In mammalian cells this activity is part of the regular processing of N-glycosylated proteins, and is not associated with protein degradation. It is carried out by EC 3.2.1.113, Golgi mannosyl-oligosaccharide 1,2-alpha-mannosidase. The names of the isomers listed here are based on a nomenclature system proposed by Prien et al [5].",384,1.0,0.029306976,-0.04986423,-0.021464525,-0.05004298,0.039658688,0.010880613,-0.012282241,0.058950778,0.0032619878,0.056585852,0.023326226,0.07909871,-0.11243306,0.042073138,-0.07184791,-0.043733347,-0.038547605,0.034186292,0.0046667987,-0.06873199,0.11792523,0.033129115,0.009340343,-0.01591816,0.031830616,-0.0661158,-0.014940744,-0.037387956,0.018536868,-0.111263625,-0.017325569,-0.08952988,0.0242905,-0.012823772,0.02799912,0.0498526,0.060494993,-0.03947817,0.015842019,-0.059582353,0.013400997,-0.07243475,-0.019233076,-0.005026458,-0.050297868,0.008520771,-0.04656003,0.010042944,0.059224386,0.09325534,0.0039188755,-0.053833757,-0.016094487,0.03914613,0.029312924,0.023814432,-0.07649607,-0.022537783,0.042926706,0.07115291,0.00095750054,-0.018158598,0.052689955,-0.015628185,0.01863878,-0.07699916,0.06351398,-0.046089526,-0.028903529,0.056662027,5.422572e-05,-0.016929897,-0.07283955,-0.032844707,-0.0027946315,0.084571645,-0.06569281,-0.07168991,0.0029874318,-0.005560136,0.07230268,0.072237164,0.12201417,0.057294965,-0.044331163,-0.011284217,-0.02742685,0.026316522,0.10298043,0.0009701327,0.012281717,-0.012691068,0.082344465,0.025516815,0.013480531,-0.009811744,0.012951321,0.04880248,0.000408634,-0.016210852,0.0066702426,0.027082006,0.0019113354,-0.1032347,0.0060537215,0.09507765,-0.02524004,0.019053983,0.083423264,0.046110295,-0.00474728,0.028561128,-0.0071707135,-0.037299763,-0.09248351,0.008993348,0.018881168,0.0058896653,-0.032926172,-0.07802918,0.0033996645,0.062509865,0.051250957,0.025954973,-0.060061168,0.023262374,-0.035283603,1.3662216e-33,-0.008743401,-0.024666231,0.014810784,0.060310777,0.028778236,-0.042470194,-0.020890454,-0.009240662,-0.029665872,0.009884457,-0.08286912,0.008361827,-0.065490626,0.12902881,-0.022016032,0.0652702,0.033100102,0.0068523465,-0.009234527,-0.052352015,-0.03489064,0.07492894,0.030364988,-0.032219756,0.12860602,0.023222728,-0.052958753,0.037560366,0.0184809,-0.04551789,0.051313926,-0.05256073,-0.08296146,0.012552518,0.0484915,0.007876213,0.010395309,0.012180547,0.014421977,0.030468112,0.01317205,0.024740862,-0.046250075,-0.08487885,0.036580898,-0.031189293,0.051051963,0.04700248,-0.04821214,0.02266144,0.04100934,-0.04080302,-0.03896912,0.018741278,-0.07387927,0.0025887564,-0.0014577828,-0.00997226,0.0012504943,0.08725555,0.002251031,0.036499694,0.04016357,-0.015150481,-0.00022955911,0.012006114,-0.072265945,-0.0071017127,-0.02083238,0.009185673,-0.03959841,-0.011883561,0.09470443,-0.006906379,0.04228961,-0.065673776,-0.05774204,0.018003901,-0.011061741,0.021471571,0.052812576,-0.020283593,-0.071549,-0.012819441,-0.084728904,0.033830322,-0.019718697,-0.11015842,-0.050520055,0.01610895,0.00066570437,-0.024796829,-0.09462229,0.097598456,-0.0866125,-4.1637406e-33,0.08997647,-0.098468006,0.08025708,-0.02954135,-0.086573005,0.01424092,0.046703413,0.006990837,-0.011458314,-0.0861052,0.02498624,-0.059647463,0.040969107,-0.0046729427,0.04365539,-0.045998894,-0.057739668,0.08613557,-0.057797365,0.027548121,-0.059737764,0.09817587,-0.0292485,0.008980516,0.10244846,-0.0006597539,0.0668956,0.07834959,0.03909648,0.019927176,-0.051903542,-0.021060964,-0.04974453,-0.049528778,0.0235896,0.0006549302,-0.024953527,0.021547098,-0.008109519,-0.07860849,-0.0034534272,0.102411635,-0.027625414,-0.0053017605,-0.0006116951,0.06302227,-0.091915675,0.05128048,-0.050525464,-0.01837489,0.016430976,-0.07097863,-0.06514967,0.04555236,0.059935976,0.08046153,0.005963917,0.00055644615,0.012811907,0.024624279,-0.030304717,-0.0152818905,0.056845587,0.001327768,0.0639495,0.08502189,-0.064866655,-0.02079225,-0.0043845265,-0.008402678,0.07390946,-0.019558327,0.014487598,-0.0013153706,0.0048330086,-0.002138335,-0.11333545,-0.07230964,-0.025682807,-0.060628243,-0.051576294,-0.049378574,-0.01209117,-0.019997327,0.06153633,0.003332412,0.065823436,0.16633883,0.01923179,0.092689306,0.040637188,-0.047093928,-0.084716626,0.08706107,0.018849896,-4.3153747e-08,0.06812784,-0.016391883,0.044816297,-0.13413434,-0.04784212,-0.0036205347,0.046446115,0.05836996,0.028163418,0.011746317,-0.012593789,0.07622065,-0.017112298,0.02201787,-0.038942955,0.023588179,-0.07142502,0.06364478,-0.016437534,-0.00011356394,-0.13545473,-0.023014272,-0.045760725,0.05437784,-0.0061799944,-0.032348033,0.05064585,0.109291874,0.0010523763,-0.06764729,0.026573576,0.05759469,0.028779792,-0.06390277,-0.015454288,0.021308858,0.004654674,-0.043671016,0.010476148,-0.005624121,-0.037463848,-0.03444926,0.029397398,-0.04716613,-0.013544713,-0.024417613,0.029938065,0.08255639,-0.033948023,0.051134452,0.006961271,0.0063217753,-0.078251444,-0.05788643,-0.0797401,-0.08868228,-0.059597317,0.014529652,0.007324648,-0.05331234,0.020683516,-0.08861034,0.10478663,-0.070589095 +3.4.13.23,"The enzyme participates in a widespread glutathione-mediated detoxification pathway. In animals the activity is usually catalysed by enzymes that have numerous additional activities, such as EC 3.4.11.1, leucyl aminopeptidase, EC 3.4.11.2, membrane alanyl aminopeptidase, and EC 3.4.13.19, membrane dipeptidase. However, in the bacterium Corynebacterium sp. Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task.",384,0.99999994,-0.052774332,-0.0771053,-0.05129983,0.058957864,0.054420106,0.04003913,-0.004883748,0.043000363,0.043035205,0.03087784,0.036880158,-0.0032692172,-0.038161483,0.044734668,-0.005453308,0.04722254,-0.0933531,-0.039312046,-0.06690792,-0.105712645,0.098481864,0.0071895123,-0.07394687,-0.028058195,0.054755088,-0.029478887,0.015695985,-0.045482974,-0.0012721355,-0.069519185,0.013405925,-0.08748824,0.012181569,-0.01743647,0.08043023,0.045083366,-0.11715726,-0.06949445,0.10657338,0.007218331,0.035272844,0.051934563,-0.036207963,-0.03690894,-0.071738586,0.05359748,-0.015802372,-0.002599919,0.069897525,0.012387347,0.020021116,-0.098267086,-0.011562736,0.042226635,0.06962955,0.015701873,-0.07602344,-0.088419765,0.03440869,0.0520906,0.014599403,-0.021429632,0.047425523,-0.00088412967,-0.011508601,0.0032614274,0.02825474,-0.06714885,0.032889392,-0.058681473,-0.061219558,-0.07393878,0.012635465,-0.018671643,-0.04686522,-0.006361789,-0.06434269,-0.060259774,0.014173211,-0.020274088,0.040078178,-0.01583221,0.040098917,0.07738032,0.034646366,-0.048523806,0.049029727,-0.08334473,0.0046864543,-0.047681607,0.01902236,-0.0035798175,0.0048305783,-0.060067017,-0.083929405,0.0033047039,0.032520566,0.0108056795,-0.09835366,0.0084319115,-0.01204998,0.09126066,-0.026775723,-0.07437449,-0.030205417,-0.022030989,0.04466236,0.035811607,0.035544537,0.05991543,0.03004078,0.043966047,-0.012824529,0.03286041,-0.005234601,0.036541477,0.09099288,-0.06747676,-0.08042286,0.047985636,-0.026487265,-0.011612189,0.06942213,0.033527594,-0.0065243444,0.035991974,-0.04785072,1.7816676e-33,0.029302645,0.010480058,-0.039519485,0.007748811,0.044556458,-0.045015953,0.006956154,0.059695758,0.07055481,0.0054032146,-0.1321072,-0.093083195,0.012077297,0.03367765,0.0038990355,0.053885702,-0.04059458,-0.033444475,0.046472717,0.008293105,0.07079406,-0.08159113,0.017856808,-0.005315927,0.046692085,-0.0038810747,-0.0044979835,0.028166248,0.051313378,-0.017460603,-0.006344496,-0.05349685,-0.115404375,-0.003861938,0.009507315,-0.032110147,0.018882386,-0.054013204,0.018336507,0.045729958,-0.025119731,0.05101665,0.0023446144,-0.055105943,0.09511886,-0.019731281,-0.038757797,0.057872187,0.03306386,0.024942402,0.05445208,-0.068958655,0.11942936,-0.008124723,-0.033303574,-0.025362674,-0.040884074,-0.061382487,0.0356967,0.07437726,0.076871656,0.03346755,-0.06825779,-0.0015327364,0.038941912,0.13239332,-0.08632104,-0.018833103,0.019601678,0.040768716,-0.07203702,-0.016552107,-0.04315109,-0.018618267,-0.053746194,-0.010773488,-0.10310098,0.0025917692,0.0121824,-0.008984267,-0.0030213054,-0.04041065,0.012202486,0.029488672,-0.040318016,-0.06490882,0.00039725678,-0.061896127,-0.0058283196,-0.022811335,0.10538203,-0.0069722505,-0.048177347,0.031655587,-0.0219737,-2.4254014e-33,0.09683266,-0.0974431,-0.022111507,-0.099010736,0.020038642,0.07922373,0.023431648,0.056827296,0.045974165,0.0006702081,0.03329334,0.092025995,0.06387446,-0.016540527,-0.00499639,-0.018000768,-0.026886081,0.0697785,-0.00917287,-0.05463904,-0.03433362,0.082863756,0.056690987,-0.009027205,0.077329636,0.008475624,-0.046477076,0.061981123,0.055780258,0.045844693,-0.00081920635,0.085441425,-0.002860598,-0.0102527365,-0.081228785,0.047216684,-0.023131061,-0.015854048,0.028631901,-0.011016594,0.054698594,0.0056573125,-0.0016437583,0.09651465,0.014545194,0.03345255,-0.088141605,-0.026062036,0.021835504,-0.10506597,0.028617011,-0.06551593,-0.00019151269,0.023736741,0.020065004,0.046929255,-0.0011539961,-0.048644617,-0.06244211,-0.006271576,-0.041767646,-0.037447885,0.016378246,-0.007152681,0.032133777,0.039924353,-0.035613995,0.054189138,0.0053233393,0.021301331,0.06983939,-0.004189394,-0.05105203,-0.017082667,-0.07717454,0.039319046,-0.042649757,0.01761623,0.0137103535,-0.04833754,-0.0222939,-0.019030204,-0.0663515,-0.016066879,-0.03308971,-0.060109507,-0.012330893,0.109601304,-0.00017956704,0.037901886,-0.087798566,-0.089320235,-0.06427787,0.05539325,0.031715143,-4.1415273e-08,0.024345366,0.07877804,0.06260419,-0.010936055,0.053189192,0.07117366,-0.0030819143,0.062087145,0.06178481,-0.040482316,-0.0047213347,0.078712076,0.0017068521,0.06393372,0.02020758,0.08814161,-0.0541629,0.027796477,0.024639217,-0.007009441,-0.06099326,-0.06240925,-0.07784251,0.044771414,0.031340804,-0.0918398,0.06662353,0.079391934,-0.05947324,-0.015183909,-0.033578735,-0.0067168493,0.0390964,0.018297281,-0.031605065,0.05907419,0.015647933,-0.0010787724,-0.012693712,0.03433281,-0.015311638,0.033749167,-0.14570148,-0.022207284,-0.01775187,0.025549043,0.05632093,-0.0027483806,-0.016039638,-0.028368503,0.056149404,-0.01367908,-0.024320548,0.075913966,-0.09969293,0.0025287182,-0.09893306,-0.05810351,-0.019499099,0.0065387003,0.08885146,0.0057662483,0.1562129,0.04260406 +3.5.1.134,"The enzyme, isolated from the bacterium Pantoea agglomerans, is specific for its substrate and does not act efficiently on other indole-3-acetate conjugates.",384,1.0,-0.025602056,-0.08371807,-0.06344747,-0.044874385,0.02065727,0.04783544,-0.023361387,-0.01583129,0.04584404,0.010860407,-0.021099638,-0.012809985,-0.07788921,0.043730292,-0.009141006,0.06608153,-0.010258062,-0.015131299,-0.013094019,-0.042757235,0.035796568,0.0077454257,-0.0047702654,-0.04246156,0.08504314,0.0060588387,0.037048258,-0.08297936,-0.077239685,-0.07895878,-0.046573617,-0.027020548,0.02547126,0.01846882,0.039941866,0.036950476,-0.088739984,-0.012866941,0.09070059,-0.061766546,0.047888167,0.03643053,-0.0008952348,-0.044623487,-0.020373905,0.05990655,-0.030886788,-0.0129087055,0.036548242,-0.052839812,-0.10004146,-0.05600871,-0.013871802,0.0027461543,0.02592333,-0.018191012,0.011375023,-0.024015991,-0.047889862,0.039041474,0.052666903,-0.005510015,-0.04193951,0.027993903,-0.035502005,-0.107324325,0.075488456,-0.03315883,-0.023979517,0.033035226,-0.05892847,-0.023786407,-0.0077099623,0.02285002,0.047211118,0.009507921,-0.057080425,0.03176097,0.028489476,-0.059695728,-0.0027520228,0.006956628,0.02547304,0.09693503,-0.017031968,-0.0035095392,0.031101948,0.028659126,0.06738227,-0.013385771,0.03242036,0.038444992,-0.0045192074,-0.09133809,-0.027639698,-0.025493026,0.033773065,0.014212141,0.0056745647,-0.003655571,0.09102087,0.03693905,0.0021426822,-0.08036873,-0.14937787,0.0030682127,-0.0015982579,0.009408309,-0.0122333225,0.05093373,-0.0065317675,-0.0033222889,0.07107845,-0.019792808,-0.09604446,0.053171057,0.026144674,-0.06350014,0.009354856,0.006791073,-0.020117994,-0.06679332,0.120230004,0.11308681,-0.050842393,0.053300522,-0.053383023,1.2819708e-34,0.080047116,0.004169803,0.016487714,-0.061654355,-0.022510754,-0.018306727,-0.044459924,-0.00052133325,-0.06137853,-0.038228944,-0.066403545,-0.055333775,0.06386489,-0.018196268,0.033623602,0.09925645,-0.030692402,-0.046100177,0.028937615,-0.04539585,0.011359942,0.04835814,-0.049245726,0.03595577,-0.03874076,-0.010181843,0.059905775,0.017734088,-0.013241645,0.005180416,0.07539645,-0.05393698,-0.050179202,0.06316077,0.0019033278,0.04079018,-0.05163809,-0.045975477,-0.048026703,0.09292323,0.06659203,0.08951361,0.08768181,-0.0037803955,0.036672466,-0.021449728,-0.049367055,0.09603003,-0.026294723,0.08701701,-0.011527975,-0.055626053,0.10459606,-0.034124944,-0.00767417,0.09204596,-0.013986935,0.015971124,0.07534383,-0.001569973,-0.052060287,-0.008859905,-0.05928021,-0.016687172,-0.048398852,0.09286178,-0.07959862,-0.029459717,-0.014616996,0.11992757,-0.022243127,-0.004938948,-0.02521525,0.103038535,0.027767366,-0.070898935,-0.0076759816,-0.0065304097,0.0055828965,0.012520579,0.04332059,0.006179575,0.02449055,0.0031391468,-0.08119986,-0.07817746,-0.049219612,0.0028006304,-0.064974755,0.05828989,0.09961754,-0.061638772,-0.092667095,0.08734926,0.027778165,-1.8346278e-33,0.05805836,-0.095911354,0.00509871,-0.043595362,-0.06700366,0.073269315,0.027364738,0.010109532,0.011487756,-0.018349312,0.025751127,0.024404904,0.0972635,-0.008341654,0.00956142,-0.083544455,0.00095866766,0.073131666,-0.03284036,0.049258757,-0.056264006,0.070429705,0.02993618,-0.0018443889,-0.0085115675,0.01451051,-0.084357575,0.10535705,-0.009695632,0.051206235,0.048474014,0.0036827312,-0.04604633,-0.029672429,-0.02240515,0.015893599,-0.015339148,-0.016349839,-0.040300444,0.026744796,-0.034086842,0.092817724,0.044199076,0.016729575,0.06316348,0.037346765,-0.065481946,0.06335257,-0.034464207,-0.07283428,-0.012858193,-0.041402765,0.048977137,-0.0795333,0.07998151,0.06889382,0.040084336,-0.019926991,-0.07614004,-0.056038752,-0.073293015,-0.04580211,0.06974922,-0.024690576,0.028664343,0.118283756,-0.02079555,0.12375554,0.024636421,-0.049144033,-0.07559889,-0.036993753,-0.022667661,0.016181001,-0.049705096,-0.020496052,-0.09676666,0.0046133697,-0.0018977921,0.016315913,0.05236099,0.00501762,-0.009114347,-0.10283768,-0.0020652767,0.021619502,0.003146448,0.08873216,0.026129218,0.05292216,-0.051969696,0.04395432,-0.020152243,0.07389895,0.06818198,-2.9206834e-08,0.07546921,-0.0020844736,0.086577654,0.0019904021,-0.090912946,0.043375682,0.011797275,-0.02772712,0.04155745,-0.053584818,-0.08039073,0.05149878,-0.037471853,0.026730232,0.018569168,0.032856863,-0.011585591,-0.03876509,-0.048064888,-0.017818192,-0.075779475,-0.021127272,-0.08011953,0.04943881,-0.006467579,-0.025113847,0.020526942,-0.014596337,0.009683335,-0.065225445,-0.062107056,0.062664576,-0.0062671877,0.0020168792,-0.12835197,-0.007515544,-0.010617736,-0.02329927,0.025344124,0.04900238,0.08522315,-0.020371817,-0.08905775,0.01202667,0.012882298,0.017749539,0.016404778,-0.05139613,-0.064341135,-0.026515007,0.022175655,0.021883842,-0.002391518,0.0120439185,-0.0525465,-0.06748122,0.01351798,-0.049929745,0.014505789,-0.03267712,0.018929645,-0.031088207,0.12826191,0.08639212 +4.1.1.118,"The enzyme, characterized from the bacterium Syntrophorhabdus aromaticivorans, participates in an anaerobic isophthalate degradation pathway. The enzyme requires a prenylated flavin mononucleotide cofactor.",384,1.0,-0.06598189,-0.035425235,-0.097845554,0.009091431,0.040844243,0.046312664,-0.026497358,0.014641419,0.031755667,-0.02296346,0.006657352,-0.09410371,-0.11868002,0.07020732,-0.01666341,0.04299443,-0.081381485,-0.022016652,0.030052463,-0.030596873,0.0058476734,0.015097139,-0.018678311,-0.002673869,-0.006577146,-0.03432337,0.05312578,-0.070420496,-0.006917397,-0.014769398,0.046421714,-0.034914866,0.07468201,-0.030730605,0.069857925,0.14154734,-0.02851767,-0.08110971,0.10926372,0.044707064,0.03826715,0.007976334,0.024366073,-0.044343237,0.0065275757,0.008947303,-0.028830541,0.04217097,-0.016022267,-0.005333581,-0.056358323,0.014259337,-0.024139617,-0.016752714,-0.005090733,-0.02596173,0.0066274367,-0.04957744,-0.11216361,0.013650567,0.059268028,0.031301238,-0.014215313,-0.016611226,0.012443403,-0.087448135,0.12222009,-0.05891883,0.07952341,0.02697556,-0.10953147,-0.05422102,-0.05287731,-0.022179486,0.0053914743,-0.0021276786,-0.027812665,-0.028002165,0.050845936,-0.10177864,0.021449242,0.018482625,0.01721479,0.03080937,0.033662554,-0.0075425627,0.008335443,0.01191313,0.033594545,0.055183545,-0.015720658,0.013330979,0.056925993,-0.09084809,-0.09910198,0.02612267,0.06405554,0.06729347,0.045754734,0.012093899,-0.012388588,0.013281855,-0.04719763,-0.059291657,-0.06811366,-0.04654549,0.061685663,0.084129184,0.059714843,0.018554803,-0.009232951,0.06694838,0.06661655,0.007310967,-0.040399168,0.0524133,-0.03330747,-0.063077554,-0.023894371,0.09376684,-0.032795765,-0.073821224,0.021175725,0.049165897,-0.034574125,-0.01786089,-0.07281753,4.150878e-33,0.08545639,-0.03294679,0.009493343,-0.042016406,-0.04865303,0.009781107,-0.080229536,-0.03785573,-0.033150602,-0.08066873,0.028443096,-0.10155876,0.04337802,0.050654456,0.017832287,-0.02730222,-0.09712059,0.04991079,0.060060084,-0.052531373,0.0144739095,0.055409614,-0.029212467,-0.0072841453,0.055620413,0.03742266,-0.01475296,0.07614445,-0.07160697,0.006661501,0.025331454,-0.08456385,-0.13584821,0.017805256,0.10550604,-0.04224485,-0.040883668,-0.012152046,-0.054401666,-0.004525392,0.023750082,0.04765326,-0.009929942,-0.03761084,0.018880147,0.0098861735,-0.03224692,0.11253205,0.05043503,0.03448219,0.019809512,-0.033303387,0.13227785,-0.038517777,-0.02648187,0.04840279,0.03732313,-0.07258003,-0.029675612,-0.036721837,0.016630014,0.049642887,-0.06662759,0.0024946677,0.06634049,-0.048824593,0.00019199013,-0.011963969,0.10117434,0.040038362,-0.027657488,-0.06400654,-0.012839119,0.08373488,-0.0034673044,-0.017080776,-0.06715979,0.019900966,-0.0065236366,0.00086702866,-0.04177257,-0.0087782135,0.025226694,-0.039179046,-0.040329944,0.0029169552,0.021504194,-0.039678045,0.0012673297,0.001366702,0.060492907,-0.11466916,-0.050881542,0.04026452,0.0054925196,-4.8766937e-33,0.058443356,-0.05786362,-0.0050369413,-0.068436705,-0.0996856,0.031522755,0.0047502224,0.049230468,-0.016641254,-0.004727846,0.058252487,0.022891829,0.06265901,-0.009979469,0.0690686,0.009034329,0.037438855,0.059659805,-0.022695191,0.007260126,0.00024165414,0.023991846,-0.014534267,0.015421413,0.0074345125,0.05889503,-0.0154742235,0.07573762,0.009473692,0.026148155,-0.035085607,0.016714593,-0.052192442,-0.04407915,0.0057636313,-0.02897363,-0.042729426,0.025144551,-0.041967105,-0.04476168,0.053982336,0.04268007,0.020833578,0.029628586,0.070828706,0.023080813,-0.11162673,-0.032142714,-0.062216874,-0.011042123,0.019415492,0.004100832,0.026791746,-0.041814625,0.026332915,0.024286464,-0.021000564,0.00880564,0.03149024,-0.043186575,-0.06327178,-0.0032372386,0.06971988,0.059940927,0.05279785,0.023412231,-0.0058816876,0.06945907,0.052708026,-0.07791759,0.0839997,0.07486339,0.057442836,0.0444513,-0.054086722,-0.052818786,-0.07969979,0.0381345,0.033576313,-0.027575847,0.052260026,-0.06359441,-0.008281785,-0.07242134,-0.04528596,-0.046895064,0.0071623134,0.05042264,0.04720427,0.037212923,0.032936372,-0.051289506,-0.047007192,0.03351315,0.02126496,-3.519378e-08,0.005733004,-0.0273192,0.052790232,-0.022095513,-0.042785387,0.03461411,-4.3263157e-05,-0.031843297,0.040135644,0.02160777,0.026021471,0.061171394,0.023148105,0.04790548,0.011762797,-0.031893305,-0.047462992,5.912576e-05,-0.068112396,0.008481669,-0.098013155,-0.029993605,-0.08557312,0.09791014,0.06766311,-0.0019894692,0.0018622511,0.037995487,0.035784155,-0.023615045,0.012619219,0.061124045,0.00064149016,0.016114298,-0.1070102,0.0085151605,-0.00819534,-0.06718897,-0.0063408623,0.09197457,-0.013195177,0.06357941,-0.12155068,0.012409919,0.07460677,0.0067052725,-0.030722452,0.03968372,-0.049391046,-0.037016384,0.017492397,-0.046904936,-0.06880799,-0.0051055364,-0.13598578,-0.0734266,0.013877869,0.04855492,-0.014934023,-0.02467942,0.097638115,0.025624756,0.21265614,-0.02050848 +4.2.1.175,"The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It is a heterodimeric protein consisting of the FldB and FldC polypeptides, both of which contain an [4Fe-4S] cluster, and forms a complex with EC 2.8.3.17, 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase (FldA). In order to catalyse the reaction, the enzyme requires one high-energy electron that transiently reduces the electrophilic thiol ester carbonyl of the substrate to a nucleophilic ketyl radical anion, facilitating the elimination of the hydroxyl group. This electron, which is provided by by EC 5.6.1.9, (R)-2-hydroxyacyl-CoA dehydratase activating ATPase, needs to be supplied only once, before the first reaction takes place, as it is regenerated at the end of each reaction cycle. The enzyme acts on (R)-3-(aryl)lactoyl-CoAs produced by FldA, and regenerates the CoA donors used by that enzyme.",384,0.99999994,-0.07103652,-0.0707556,-0.070798546,0.0020597586,0.12484546,0.055489447,-0.060601156,0.0070128953,0.036606908,-0.016694073,0.023347812,-0.08881602,-0.060795836,0.077089965,-0.061033048,0.014934663,-0.06776428,-0.032095257,0.018722663,-0.06310769,0.05718691,0.016027348,-0.011494714,0.011454936,-0.0006727838,-0.03911692,0.04941906,-0.06499209,-0.07921343,-0.07813626,0.020436713,-0.040619936,0.091202654,-0.041511934,0.02169508,0.122763194,-0.02274716,-0.084147304,0.10860819,0.036635984,0.028243175,-0.044250786,0.017082471,-0.038258314,-0.004433997,-0.03353087,0.04309234,0.049316235,0.046314813,-0.022705581,-0.04254518,-0.015791068,-0.043927584,0.01647822,0.0008809055,0.037699692,-0.012198285,-0.017419508,-0.038768254,0.023507692,0.040778525,0.008050626,0.00021539172,0.0011648294,-0.037683498,-0.07423722,0.01989545,-0.05899512,0.07943426,-0.013962375,-0.073359214,-0.028734796,0.010141957,0.007264726,0.0257078,-0.0010666744,0.043006744,-0.041462768,0.038303565,0.029942686,-0.016391285,-0.018735189,-0.0071279947,0.0020990085,0.07841134,-0.08265375,0.017523784,-0.023095788,0.054191176,0.020686671,0.0581429,0.059464663,-0.044774756,-0.005043781,-0.025792286,0.01512352,0.04113308,-0.0074549383,0.016929002,0.008459478,-0.010048129,0.07193803,0.024085278,-0.07264075,-0.03908356,-0.039557163,0.018117419,0.108694464,0.040402956,-0.0016258296,-0.010975323,0.008063697,0.0752392,0.02780086,-0.027020331,0.12795758,-0.0009013077,-0.09394267,-0.05630403,-0.0026867436,-0.012127655,-0.015285206,0.1356573,0.08874908,-0.020923952,0.017770551,-0.111644834,3.207399e-33,0.089054815,0.0010043932,-0.0033933765,-0.0030975025,0.005109236,-0.019430105,-0.09411832,0.04597384,0.00050130824,-0.043842763,-0.02592302,-0.07077072,0.095035516,-0.009418795,-0.039918225,-0.07540236,-0.07969179,-0.00035168635,0.04975147,0.028868431,0.0067349053,0.01769535,0.005317887,0.063159674,0.030443136,0.051815394,0.02829867,0.026999643,0.037645802,0.045178123,-0.015978385,-0.10266902,-0.10746958,-0.017051514,-0.00052065094,-0.033834353,-0.06827443,-0.039775215,0.011885345,0.019314868,-0.053223893,0.08043909,0.019799894,-0.017956689,0.020799778,-0.007376048,-0.042939533,0.14555515,0.01903783,0.061045896,0.05515828,-0.06176651,0.1114699,-0.003059815,-0.04374403,0.017316354,-0.080332294,0.015958637,0.058471367,0.026291417,0.05172442,0.07984508,-0.028541612,0.054401502,-0.014822238,0.04525328,-0.01517748,-0.015614385,0.07255249,0.05828622,-0.03619335,-0.04444124,0.10432224,-0.02136137,0.06338917,-0.05006185,-0.03782317,-0.04611928,-0.01012306,0.020062577,0.023485314,-0.05074881,0.023229133,-0.048821393,-0.037911274,-0.033004504,0.0073339846,-0.019677306,0.017031098,0.019526908,0.08472158,-0.042593554,0.009773234,0.03818528,0.017769765,-2.2606793e-33,0.120823845,-0.14436573,0.0011603533,-0.11269767,-0.028484596,-0.012667951,0.081428014,-0.017583443,0.010307445,-0.094913036,0.07848456,-0.027028682,-0.027044214,-0.008467459,0.015234859,0.010015954,0.0013218818,0.017398778,-0.0039158147,0.03985255,0.016845044,0.027920617,0.016169999,0.027998175,0.069723345,0.07009159,-0.08029854,0.032875333,0.037563443,0.07745234,-0.021412106,-0.0024734254,-0.047160283,-0.0037184919,-0.034840252,0.058278866,-0.02977618,0.012270619,0.032636907,0.045416165,0.06433325,0.015552523,-0.023176508,0.016357623,0.029414747,0.091786265,-0.039035887,-0.008991686,-0.044883765,-0.07288884,-0.0023751108,-0.021680335,-0.029654315,-0.039161094,-0.0041035675,0.041087955,0.023951028,0.0210144,-0.03851865,-0.007877034,-0.040012993,-0.09450942,0.054115824,-0.013128303,0.061069842,0.026637735,-0.021843614,0.11828012,0.035534855,0.027721548,0.08012653,0.0685698,0.05900224,0.059422728,-0.0052426346,0.008638059,-0.07274579,-0.051049385,-0.06668232,-0.021509245,-0.027501674,-0.0006566542,-0.025243454,-0.016111178,-0.051207725,-0.08392159,0.033699214,0.06853329,0.010401493,0.03964702,-0.038642496,-0.015897498,-0.008151633,0.06694549,0.095673464,-5.3799138e-08,-0.028949661,-0.08944578,0.02501431,0.0028499116,0.047397897,0.07165842,-0.021621076,-0.025160078,0.042892445,-0.12282707,0.008028843,0.14068432,0.029454196,0.025017211,-0.008651697,-0.056406643,-0.07808209,0.008006674,-0.014745261,-0.06769663,-0.08807618,-0.034727626,-0.13218476,0.027065245,0.0060532163,-0.03974019,0.018931674,0.044269565,-0.014045639,-0.10984192,0.00010124712,0.020263843,0.0056703994,0.04896042,-0.076633625,0.013183825,-0.05308443,0.0043685366,-0.07417513,0.01994691,-0.026198553,0.015695602,-0.07423819,0.007877643,0.04175563,0.019108051,-0.00018820332,0.031410046,-0.0048241545,-0.0030337297,0.041661605,-0.0026261967,-0.013524529,0.019096525,-0.04673852,-0.020850852,-0.08547422,-0.057885177,0.021809734,-0.05851897,0.016382273,0.00037709932,0.1597944,-0.05786152 +4.2.3.205,The enzyme has been characterized from the bacterium Serratia plymuthica.,384,1.0,-0.022562116,-0.05105653,-0.11178583,-0.02017349,0.00053965085,0.04439433,-0.123347946,0.07713791,0.04631418,-0.071049444,0.0059673027,-0.071896285,0.036354527,0.08674113,-0.03544285,0.013847722,-0.044978637,-0.022056786,0.037894003,-0.015655715,0.09601726,0.01867522,0.0034263192,-0.016478194,0.027473286,-0.015433589,0.08158558,0.022029359,-0.0033334831,-0.06490469,0.0028835037,0.0007948361,0.08541219,-0.048128024,0.088320084,0.03472161,0.035421263,-0.049457382,0.06584648,0.038524736,-0.0049320497,0.032585565,-0.015654257,0.009416224,0.009908693,-0.035373565,0.054935362,0.069008134,0.05776,0.027438961,-0.078103356,-0.058501936,-0.070552036,0.016562402,0.06872759,-0.025821913,-0.0019913577,-0.061048217,-0.0054693418,0.021395858,0.048468348,0.017316416,0.034557976,0.0222556,-0.05709812,-0.024178768,0.034194607,-0.0455455,0.024531888,-0.03942032,-0.09697088,-0.04701866,0.029254688,0.045074955,-0.0066142986,-0.047633592,0.011831028,0.0066674096,-0.018519044,0.01871969,-0.07671853,-0.00811894,-0.04856631,0.059312027,0.04049542,0.047367856,0.050596926,-0.0035289226,0.042440854,0.0037154064,0.024911592,-0.049226254,-0.05025023,-0.039917782,-0.08663019,0.04005536,-0.062740006,-0.0638049,0.054094587,-0.051654663,-0.07241701,-0.0071488833,0.016252298,-0.13170895,-0.055802856,0.02346419,-0.010257821,0.08836603,0.0042403694,-0.04158004,0.022687413,0.0699822,-0.05050891,0.011349043,-0.016744278,0.048671503,0.026610617,-0.062635876,-0.036679193,0.009614254,-0.0035849977,-0.037997995,0.021371376,0.04964424,-0.013003203,0.0411369,-0.093405895,-1.6956374e-33,0.07201418,-0.008124869,0.023564298,-0.028542507,-0.027743341,-0.047679365,-0.0054765837,0.016642518,-0.08910269,-0.0038665407,-0.022185134,-0.10891326,0.009859899,0.061450154,0.066986285,-0.02384,0.032977644,-0.027362393,-0.02288628,0.0019189431,0.041093975,0.07904531,-0.017200954,2.0064868e-05,0.08173762,0.03834585,0.021619499,-0.009928967,0.109212354,-0.020107033,0.0044640666,-0.028740792,-0.11352497,0.02161673,0.07195138,0.052944727,0.029668486,0.0054460345,0.0106283175,0.10388038,0.05082584,-0.004336098,0.016244164,-0.0020861921,0.103583254,-0.095280625,-0.06439272,0.06553031,0.063532524,0.016804658,-0.00033626612,0.01668201,0.15545194,0.041016847,-0.08028571,0.014927694,-0.03285656,0.02065747,-0.044237927,-0.019500308,-0.009764337,0.017134141,-0.027113581,0.041549984,-0.012604818,0.025737204,-0.038607243,0.01335087,0.05000941,0.09992095,-0.06282215,0.026132978,-0.059531655,0.010554742,0.012534921,-0.07970058,-0.07926616,-0.0036154143,0.08611698,0.025424467,0.0037297597,0.012068017,0.024780285,-0.05482755,-0.10686678,0.018757239,-0.006457328,-0.0041431217,-0.03167753,0.020397538,0.07054887,0.008822028,-0.010402135,0.07193426,-0.06926702,-4.9602124e-34,0.057401937,-0.119304776,0.10077483,-0.004682842,-0.054596927,0.06107378,-0.049806036,0.056172334,-0.082070045,-0.025154246,0.047983747,-0.031621996,-0.00833293,-0.06396417,-0.02100561,0.07511108,0.010861749,0.034328606,-0.034917098,-0.0512612,-0.07638275,0.010764664,0.048932645,-0.12770402,0.017622598,0.04921571,0.048091166,0.09511922,-0.016911753,0.023596387,0.0106966365,-0.005716204,-0.08283105,-0.06274189,-0.06684995,0.057222165,-0.05267797,-0.007862446,0.05168279,0.03478548,-0.029461581,0.058371734,-0.007903925,0.079852626,0.048632305,0.077341355,0.019344553,0.0010414008,0.05220074,-0.030978067,0.034411613,0.013047243,0.0710554,0.00345152,-0.0034438476,-0.03298378,-0.044502135,-0.02647072,0.024704508,-0.061798446,-0.023896024,-0.09954702,-0.019493204,0.04307446,0.09684804,0.036327627,0.01624247,0.01812704,-0.0006821399,-0.07291155,0.047317874,0.010282792,-0.044791486,0.08149169,-0.054909997,-0.0038474032,-0.11701812,-0.08192682,-0.011169696,0.04674358,0.005975693,-0.021707248,-0.06077685,-0.028160488,-0.011989569,-0.05617502,0.050550636,0.03440438,0.032841217,0.03285348,-0.06686858,-0.019437214,-0.07372163,0.014061178,0.10092035,-2.2026356e-08,0.098867804,-0.08029464,-0.033742134,-0.03750706,0.0018521246,0.023658413,-0.07160882,-0.075309075,0.039788604,-0.04297281,-0.049192164,0.02862213,-0.023815133,0.066811346,0.011357988,-0.019763628,0.05509694,-0.026657103,0.01853718,0.010255662,-0.053867076,-0.040288787,-0.07521602,0.061004702,0.0028993054,-0.021085419,-0.028185286,0.030244198,-0.016575683,-0.01981556,-0.09041807,0.028637538,0.028102295,-0.028705364,-0.08152561,0.042222697,-0.04221732,-0.0067527355,0.0018894785,0.050267357,0.15058286,-0.043384552,-0.05475106,0.0073301843,0.011021119,-0.028463993,0.013902176,0.022542458,-0.009865953,-0.06736949,0.06320177,0.018317875,0.039828066,-0.016521942,-0.13119589,0.055371307,-0.009286052,-0.07790196,0.008389122,-0.031458754,0.01337107,-0.013160542,0.122022636,-0.0037059302 +4.6.1.23,"Ribotoxins are rRNA endonucleases that catalyse the cleavage of the phosphodiester bond between guanosine and adenosine residues at one specific position in 28S rRNA. The enzyme secreted by Aspergillus giganteus specifically cleaves rat 28S rRNA between G4325 and A4326 and displays cytotoxic activity toward animal cells. It can also act on bacterial rRNAs. The enzyme catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides.",384,1.0,-0.009019311,-0.061245248,-0.075955346,-0.026289426,0.059876457,0.01904598,-0.07830457,0.016525595,0.019922392,0.071629025,0.014785819,0.020132113,0.0056783715,0.13167888,-0.08870577,0.054755595,-0.10054763,0.035531312,0.03783406,0.01911942,0.106502324,0.081964865,-0.06094186,0.04644222,0.026941556,0.01720609,0.081401914,-0.04520379,-0.07680317,-0.046253923,-0.006431306,-0.119647585,0.023041248,-0.028173555,0.01653115,0.11535867,-0.07937866,-0.019858148,0.051076114,0.02387812,-0.015806258,-0.019506184,-0.013225662,-0.02154758,-0.003927131,-0.008048705,-0.041491006,0.06999044,0.041926716,-0.02642583,-0.030109355,-0.064393625,-0.042362478,-0.010118385,0.070376515,-0.011493604,-0.06675721,-0.05313354,-0.017163636,0.017432014,0.010868809,-0.061462782,-0.0685132,-0.0053002313,0.0099954,-0.052154656,-0.0151324235,-0.022634542,-0.01687062,-0.026864642,-0.016775694,-0.06304582,-0.0089476155,-0.005026329,0.020848045,0.050942827,-0.004826708,-0.0020982488,-0.005490088,-0.019742973,0.049168967,-0.022357369,0.07098187,0.035283852,0.07065839,0.00933587,0.0021700219,0.065081075,0.0282416,0.027885104,0.062786326,0.029722624,0.02347534,-0.011929038,0.0132309655,-0.011859036,0.011278625,0.04071566,0.025659237,-0.06784709,0.012241117,0.024700033,-0.047004063,-0.0860097,0.050316982,0.06877059,0.015888542,0.08591889,0.016154563,-0.015787646,0.01813322,0.032664355,-0.04121606,-0.08699179,0.026869405,0.11546008,0.05149472,-0.014660556,-0.013770588,0.033072412,0.019811988,-0.008910333,0.0018450177,-0.0033929856,-0.041791473,0.048740815,-0.08090336,6.7741256e-33,-0.013913687,0.006580929,-0.06485266,0.054297816,0.04573251,0.049636144,-0.0416873,-0.042009614,-0.0008230705,-0.0082614375,-0.11545558,-0.030285483,-0.0109686265,-0.0025074834,-0.0041036317,0.008411643,-0.019266404,-0.023678226,-0.0022498264,-0.013731504,0.04389184,-0.029500917,-0.02273368,0.056993205,0.025111543,0.0077431616,-0.0368647,-0.038866065,0.03894089,-0.030904192,-0.0028984202,-0.054266606,-0.08150944,0.06222727,0.023890058,-0.036550894,-0.029049065,-0.021263337,0.042497825,0.02578658,-0.03013345,-0.029241385,-0.09876189,-0.04109417,0.05408837,-0.03770395,-0.052597027,0.08725232,0.024013603,0.056844547,0.11731516,-0.033300158,0.03933024,-0.013750092,-0.06400942,-0.053921234,-0.0024174603,-0.050263416,0.047990102,0.032361444,0.015550857,0.043825667,0.014203847,0.0026061537,-0.015218527,0.0055028866,-0.04154384,-0.102833174,-0.0018099362,0.06526204,-0.057947014,-0.023185063,0.08881235,-0.061246846,-0.01813612,-0.031365927,-0.043214656,0.0051951995,0.023426807,0.05861113,0.071909994,0.040870048,0.06457952,0.028036112,-0.05689943,0.027973872,0.013268036,-0.11677649,-0.016333416,0.0926708,0.04860974,-0.07907839,-0.017592791,0.015384688,0.017540846,-7.2618125e-33,0.15065245,-0.11540393,0.072158135,-0.07027932,-0.10844317,0.041001633,-0.004905811,-0.035786804,0.06193236,-0.07974338,0.04879801,0.007560103,0.013381617,0.039328948,-0.007917581,-0.027435122,0.06444263,0.10736151,-0.016068293,-0.04341743,0.004707521,0.0718766,-0.01744165,0.02869426,0.10357693,-0.0065657864,0.00091711234,0.014879152,0.09421977,0.041789062,-0.024001714,0.028981144,0.039411202,0.023658076,-0.0023099808,0.1014683,-0.033258606,0.0024861924,0.024923524,0.02038808,-0.006124411,0.01595783,9.199206e-05,0.024829227,-0.015617849,0.036051918,-0.009492597,0.013026509,-0.05863367,-0.12610383,0.05078262,-3.0549236e-05,-0.038036965,0.07210222,-0.019202244,-0.031914536,0.01546904,-0.011434894,0.06580054,-0.056022976,-0.043498773,-0.06930739,-0.045510296,-0.040774196,0.046708718,0.032735143,-0.026317403,0.019842485,0.057906315,-0.03406836,-0.03088173,0.010064362,0.020297272,-0.0050621233,0.017662987,-0.014293307,-0.07973206,-0.049533892,0.025831576,-0.051460616,-0.027618367,-0.004931485,0.01849855,-0.030616147,0.024232045,-0.1423775,0.05889942,0.15431936,-0.057115868,0.027278936,0.021781504,-0.017667439,0.028243229,0.06417784,0.120006315,-5.1818585e-08,0.030303348,-0.021458035,0.023485396,-0.11470127,0.007397719,0.06993014,0.065844566,0.049278315,0.068144694,-0.05026143,-0.018076193,0.05892422,0.017213427,-0.005756821,0.019225663,0.025479361,-0.08916892,0.0020579628,0.036036395,-0.026034297,-0.09708347,-0.014453045,-0.1528216,0.022003448,-0.047771268,-0.011718603,0.021918505,0.063808516,-0.017361885,-0.0430731,0.03761391,-0.0021016842,0.013936216,-0.03770738,-0.07036509,0.022642983,0.019552626,0.0021743937,0.027502108,-0.001163699,-0.066119954,-0.05876507,-0.07614001,0.019179545,-0.116420254,-0.04406176,-0.032465152,0.009495001,-0.02971037,0.024784796,0.12099744,0.011801727,-0.0049878084,-0.06672587,-0.0712435,-0.055938475,0.025188372,-0.08432889,-0.044821948,-0.04670876,-0.014224778,-0.0055029225,0.16362984,-0.032156926 +5.4.99.67,"The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 5.4.99.5, chorismate mutase.",384,1.0,-0.05362079,-0.011649488,-0.12257906,-0.037301317,0.025017006,0.033168327,-0.033159893,0.07958091,0.07716341,-0.04419616,0.014180197,-0.022488829,-0.0014685646,0.0733648,-0.0770895,0.026623981,-0.104329646,-0.0010336619,0.017378855,-0.043612916,0.13131547,0.01992819,-0.018318992,-0.0029308922,0.054573108,0.047792748,0.042855233,0.0049297716,-0.036035933,-0.05330816,0.008505277,-0.045724783,0.11529078,-0.052928448,0.088798985,0.05597426,-0.06460715,-0.05766908,0.1400981,0.029920867,0.003240176,-0.0050863554,-0.065535404,0.046115138,-0.07315394,0.014327715,0.09097567,0.047427256,-0.010518964,-0.007448927,-0.03750307,-0.033514556,-0.053764284,0.0068268618,0.011658361,0.044444993,-0.006086436,-0.059709974,-0.008263142,-0.052608434,0.026971202,0.030882722,0.03335857,-0.016523879,-0.091073595,-0.02282769,0.04013069,-0.04883691,0.036146007,-0.07378737,-0.08650744,-0.029816618,0.0093848305,0.07425999,0.016166052,0.009703778,0.021296643,-0.026835607,-0.06971192,-0.045268193,0.039275464,-0.04532363,-0.024166571,0.070071764,0.09321277,-0.013913728,0.06179854,0.009110461,0.10663906,-0.009273044,0.028407505,-0.012497878,-0.038193356,-0.049301002,-0.07183672,0.035619296,-0.10067713,0.0057322737,0.0022354375,-0.023111785,0.017562643,0.024832118,0.026686387,-0.047946833,-0.011559888,0.0056561236,0.03278607,0.072501905,0.016236905,-0.037382144,-0.030462256,0.0051325406,0.016009653,-0.013915362,-0.0056656515,0.07142478,0.041957874,-0.04861973,-0.03425544,0.010829411,0.012962433,0.027117064,-0.009204578,0.05624548,-0.008396239,0.052328818,-0.097063534,3.423924e-33,-0.020987304,0.025390083,0.007954365,-0.033718366,0.02307021,-0.025031406,-0.056921422,-0.01486203,-0.029971616,-0.06399099,-0.024701104,-0.09597577,0.011196617,-0.00058766134,0.010674041,0.01992244,0.039037384,0.05468408,0.036148544,0.057096913,-0.00406559,0.096721046,-0.061862066,0.030840838,0.07116441,0.07999434,-0.029395476,0.0002612,0.11352444,-0.044725195,0.02533012,-0.07614094,-0.045902006,-0.017127462,0.041278154,0.00015556472,-0.042394575,-0.035375673,0.024884881,0.06397827,-0.023739966,0.012372708,0.025353992,0.04569092,0.047969975,-0.04735883,-0.05715993,0.10869249,0.07670051,0.06314254,-0.008197311,-0.055137698,0.06689473,0.0015209082,-0.04394462,0.054059006,-0.026136653,0.04293842,0.03561017,0.01671709,0.016839588,0.022182949,-0.063708,-0.016667968,0.0671588,0.018299619,-0.052585714,-0.048079897,0.010334025,0.0895095,-0.1405438,-0.031321708,-0.053177092,0.062224448,0.023875693,-0.011843778,-0.06534954,-0.052476417,0.04804315,0.0022954138,-0.107353516,0.010674601,0.012468407,-0.07168886,-0.090987325,0.026518479,-0.033586722,-0.08542989,-0.011198407,0.040372048,-0.007411911,-0.072051056,-0.11131413,0.036840674,-0.005686221,-4.157286e-33,0.06635578,-0.11329374,0.08231724,-0.021951744,-0.06072522,0.113776006,-0.054224458,-0.035778042,-0.051638838,0.013061691,0.035420798,-0.060661245,-0.040024016,-0.06588932,0.0025560677,0.015520618,0.05203664,0.08056531,-0.028245687,0.037207052,-0.0070711975,0.149113,0.072645456,0.008810324,0.04417347,-0.0015930901,0.018922416,0.054106303,0.054072894,0.020289335,-0.034933224,-0.007819746,-0.016512424,-0.037957817,-0.072790064,0.06962119,-0.060638394,0.019903092,0.05671557,0.007689447,0.011015033,0.012706924,0.027446844,0.071135364,-0.042257868,0.059652768,-0.047557995,0.03339532,-0.0062442548,-0.08922585,-0.012559729,0.038612705,0.01748918,-0.0009530522,0.014136938,-0.022070501,-0.008105319,-0.038630404,0.025417386,-0.088347174,-0.024238624,-0.011591102,0.019565795,0.018089632,0.056651693,0.007108404,-0.02223918,0.03835389,0.116098,-0.03966681,0.03961837,-0.026041362,-0.046853025,0.040358208,-0.049149025,0.015908463,-0.087740734,-0.027641734,0.044104837,-0.015931357,0.016203577,-0.012743365,0.0115504,-0.05180083,-0.06444358,-0.021421073,0.036640238,0.052084226,0.052637286,0.071539864,-0.017351339,0.030119007,-0.025910575,0.038370017,0.0041459096,-3.8160078e-08,0.036674686,-0.038898256,0.04875186,-0.0033391225,-0.0037681086,-0.024611061,-0.071898155,-0.024524078,0.026575036,0.03473709,-0.042573515,-0.00064308214,0.024717415,-0.038556293,-0.010320217,0.06667816,-0.020543989,0.041978125,0.013054021,0.027650861,-0.07495122,0.0017328898,-0.17156231,0.07666873,0.068712495,-0.05581663,0.026175387,0.02804212,-0.016649803,0.02863339,0.03137358,-0.026929306,-0.00018319901,-0.06011278,-0.04478879,0.01194278,-0.08238611,-0.08220345,0.015422352,0.026240138,0.096107,0.0069206115,-0.0485037,0.008237006,-0.039944764,0.041697424,0.022805488,-0.05328863,-0.0144365905,-0.056740373,0.03169419,-0.019001687,-0.020320214,0.0140230525,-0.1175004,0.034253765,0.027796648,-0.051405307,-0.041446146,-0.05511241,-0.011869108,0.0383922,0.20311393,-0.043712933 +5.6.1.9,"Members of the (R)-2-hydroxyacyl-CoA dehydratase family (including EC 4.2.1.54, lactoyl-CoA dehydratase, EC 4.2.1.157, (R)-2-hydroxyisocaproyl-CoA dehydratase, EC 4.2.1.167, (R)-2-hydroxyglutaryl-CoA dehydratase and EC 4.2.1.175, (R)-3-(aryl)lactoyl-CoA dehydratase) are two-component systems composed of an activator component and a dehydratase component. The activator is an extremely oxygen-sensitive homodimer with one [4Fe-4S] cluster bound at the dimer interface. Before it can catalyse the dehydration reaction, the dehydratase requires one high-energy electron that is used to transiently reduce the electrophilic thiol ester carbonyl to a nucleophilic ketyl radical anion, facilitating the elimination of the hydroxyl group. The activator, which has been named archerase because its open position resembles an archer shooting arrows, binds two ADP molecules. Upon the reduction of its [4Fe-4S] cluster by a single electron, delivered by a dedicated flavodoxin or a clostridial ferredoxin, the two ADP molecules exchange for two ATP molecules, resulting in a large conformational change. The change allows the activator to bind to the dehydratase component and transfer the electron to it, activating it. During this event the two ATP molecules are hydrolysed and the activator returns to its resting state. Since the electron is regenerated at the end of each reaction cycle of the dehydratase, the activation is required only once, before the first reaction takes place.",384,1.0,-0.09768839,-0.11075273,-0.031185502,0.007726659,0.103553325,0.015191078,-0.04688805,0.03802094,0.03190274,-0.044730026,0.0047919177,-0.06608316,-0.048027012,0.085083045,-0.007949146,0.026599618,-0.097276874,-0.034243256,-0.019141119,-0.004871025,0.061514165,-0.008775544,-0.022811271,0.02045002,0.059287682,0.0045586918,0.096551515,-0.01019564,-0.08999402,-0.09937343,0.08536512,-0.04839211,0.046332188,-0.04105511,-0.017778434,0.08670783,-0.029988153,-0.026044197,-0.00018558782,-0.01308465,0.055047862,-0.02186402,-0.013773641,-0.0068517784,-0.07180865,-0.04348603,0.022112545,0.048606806,0.0031716854,-0.036009554,-0.03774474,-0.063121095,-0.0015594991,0.011829809,0.038224827,-0.056833323,-0.03245269,-0.025130162,-0.032320846,-0.020992996,0.04183211,-0.03946276,0.029127823,-0.0314737,-0.042680256,0.012012769,0.100960255,-0.024609193,0.009048478,-0.01078549,-0.089604035,-0.042833675,-0.023241777,-0.010122113,-0.018738264,-0.0019039892,-0.0044818944,0.012917304,0.055073176,-0.0064385068,-0.009630019,0.000103627826,-0.0006646188,0.09641798,0.073558494,0.026255345,0.002334249,-0.107515104,0.001991515,-0.020383738,0.0039786855,0.04251986,-0.09301895,0.0004901751,0.039910182,0.045665212,0.058909345,0.063298985,0.03744419,-0.028072162,-0.023632182,0.08855752,-0.056538552,-0.08563645,-0.015525284,-0.051268674,0.0049802028,0.09525938,0.043247733,-0.0062266453,-0.02708297,-0.0571481,0.06275308,0.087558456,-0.058021344,0.07482317,-0.042313293,-0.034421913,0.0003020829,-0.03540388,0.003117946,0.019988073,0.07201868,0.048009627,0.03520455,0.05382422,-0.12290012,3.371559e-33,0.077253,0.0018240999,-0.00093502906,0.055257566,-0.030491503,-0.06943598,-0.09360826,0.074764,-0.07234302,-0.002864867,-0.0023407857,-0.014941266,0.09526639,-0.004530266,0.0130264945,-0.093003236,-0.028052546,0.013121672,0.0037713167,-0.016392412,0.028559355,0.11333326,-0.068031535,0.05938655,-0.06427386,0.070648104,0.026786404,0.032546487,0.021645473,0.03407742,-0.05536573,-0.07374313,-0.07136963,0.049027324,0.04204624,-0.045552276,-0.11605276,-0.03973365,-0.004183915,0.005717583,-0.007600532,0.033892725,-0.028910814,-0.04424435,0.033699,-0.0102193905,-0.018028224,0.091329396,-0.008135267,0.050609306,0.018075138,0.0066387467,0.12910992,-0.057209134,-0.023969723,-0.011480766,-0.06475189,0.048101354,0.04359031,-0.004057303,-0.03425966,0.08140437,-0.033948895,0.035727505,0.013663314,0.055982105,-0.06133992,-0.054142002,0.014967676,0.022635069,0.03497396,0.0041492255,0.074127056,0.012047378,0.076094456,0.027239138,-0.0016828415,0.0121999495,-0.012597507,-0.016716503,-0.038398877,0.004137832,0.003833983,-0.021104904,-0.055416144,-0.08132401,0.017290877,-0.025100634,-0.032702,0.028350774,0.020360792,-0.09612948,-0.058418598,0.0052317497,0.03366021,-3.3445602e-33,0.12307944,-0.09733078,-0.015461713,-0.10158936,-0.027559169,0.019973492,0.069022946,-0.04338398,0.0764837,-0.035651363,0.09833389,0.048956018,-0.047155395,-0.042225894,0.047826707,0.021871528,0.020203996,-0.02703162,-0.03901515,-0.016027221,0.090263195,0.11532167,0.017409466,0.049735866,0.061280504,0.037649423,0.04596218,0.038559493,0.04981501,0.055475265,-0.016311927,0.03519997,0.011050877,0.0143758645,-0.07807657,0.05776912,-0.037818022,0.011285817,-0.0052329684,-0.016878827,0.0046749194,0.022731042,0.022526322,0.06954036,0.09793271,0.041648146,-0.057721917,-0.004646202,-0.043587487,-0.016410127,-0.029433286,-0.012719557,0.00899866,-0.007876836,-0.0029705178,0.0401825,0.069685936,-0.019404849,0.015999181,-0.0658331,-0.013753546,-0.045832913,0.071141854,0.00714929,-0.050864387,-0.0066721234,-0.015945839,0.02362686,0.047607098,-0.0456397,0.035712227,-0.028476447,0.04300616,0.048545025,-0.00885277,-0.023872849,-0.028432947,-0.07501693,-0.07681957,-0.061928432,-0.072834924,0.00021130782,-0.014361602,-0.07281241,-0.021243818,-0.08021568,-0.027172655,0.12210188,0.037668534,0.036970492,-0.023542093,-0.03247134,-0.016746422,0.12823586,0.065368846,-5.806876e-08,-0.0127966795,0.0041048885,0.07306732,-0.030371027,0.041598104,0.025644526,-0.021158533,0.06912938,0.074001126,-0.03345519,0.079626806,0.097741224,0.016833283,-0.03979252,0.06748224,-0.020293884,0.0024689839,-0.032969687,-0.04847559,-0.023342647,-0.0040134517,-0.09814917,-0.1188484,0.03529323,0.018361637,-0.07796941,-0.013197025,-0.009676936,-0.04503898,-0.03733799,0.024258833,0.063887276,0.06962348,0.07499331,-0.090094976,0.026867915,-0.044523325,0.02805519,-0.054488186,0.088609755,-0.02371665,-0.07040981,-0.05318832,0.024818074,0.0271982,0.04365768,-0.048784126,0.028914414,0.03718384,0.063605264,-0.035023306,0.009770002,-0.06392387,0.014055107,-0.10909657,0.03360333,-0.052779052,-0.021157885,0.027908355,-0.057527985,0.0473292,0.044501808,0.120517194,-0.02743549 +6.2.1.58,"The enzyme, characterized from the bacterium Syntrophorhabdus aromaticivorans, catalyses the first step in an anaerobic isophthalate degradation pathway.",384,1.0,-0.044951495,0.009018738,-0.05415019,0.016238987,0.022341933,0.038419783,-0.041055914,-0.015243162,0.03674019,0.004499365,-0.01639434,-0.082148455,-0.06208223,0.03888016,-0.0097421575,0.04372975,-0.05709313,-0.01927972,0.016206827,-0.031184781,0.018413153,-0.018378897,-0.050880816,-0.013658765,0.04969626,-0.028966045,0.060610313,-0.07965276,-0.05756084,-0.020102395,0.033549074,-0.06215999,0.07355418,-0.0342858,0.09315,0.13248125,-0.06568028,-0.05718996,0.103290886,0.021493798,0.013506141,-0.013543072,-0.0049828007,-0.07881738,-0.012550465,0.01393865,-0.02606194,0.005559764,-0.011743479,-0.088158846,-0.050841406,0.026506819,-0.028691668,-0.01620737,0.017899705,-0.057815976,0.032326277,-0.0061806357,-0.11804979,0.038868986,0.04344119,-0.0022063595,-0.015229635,-0.026677763,-0.028615972,-0.09904992,0.13200364,-0.04588611,0.07474281,0.036386177,-0.13671312,-0.06765142,-0.045391094,-0.053369164,0.025679564,-0.0011083421,-0.02667069,-0.04094205,0.030575965,-0.12569433,0.009155691,0.01660567,0.026209746,0.008310755,0.030163663,0.024815045,0.010272156,-0.021710755,0.0849136,0.03678443,-0.031631798,0.035043415,0.025580792,-0.07372237,-0.06573118,0.020433672,0.0421603,0.06935321,0.07081751,0.006722919,0.0061454345,0.03861005,-0.084213935,-0.115948364,-0.03363093,-0.028399985,0.06897557,0.102466926,0.058263663,0.022132814,-0.020896262,0.058946084,0.063928895,0.06781949,-0.0037329409,0.052935094,0.013805295,-0.027363677,-0.038198337,0.07612122,-0.031988423,-0.06370635,0.018496145,0.02333727,-0.069675036,-0.0035159083,-0.017596802,2.0192027e-33,0.066026606,0.014705421,0.0055894405,-0.03633229,-0.06709196,0.007535916,-0.09391685,-0.024432717,-9.220854e-05,-0.07164315,0.03093463,-0.1249101,0.006924245,0.038117725,0.024290487,-0.02721692,-0.10005348,0.080711685,0.055754304,-0.05138483,-0.01576079,0.057664037,-0.022501076,-0.045189522,0.048790414,0.025423646,0.017463988,0.06302667,-0.09254643,-0.008701067,0.024187557,-0.05534692,-0.16317932,0.0010357148,0.07015002,-0.031964377,-0.01339886,0.028368132,-0.045512524,-0.008791637,0.020513216,0.074687995,0.006829602,-0.05638523,-0.023377893,0.059088685,-0.038587548,0.11818764,0.057437528,0.021892209,-0.026532022,-0.022969877,0.15963237,-0.04066036,-0.051820166,0.027679203,0.055909988,-0.08951629,-0.0023811418,-0.02845134,0.011928979,0.05277679,-0.058721695,-0.0052196607,0.054517683,-0.06537987,-0.024361115,0.032652963,0.0752718,0.053975,-0.041626096,-0.029644158,0.015879255,0.05722674,0.002222582,-0.0383387,-0.09524981,0.0061663706,0.0062994147,-0.0066452334,-0.031423833,0.00626132,-0.0022238255,-0.035315316,-0.011112121,-0.0014223616,0.01613845,-0.0076567945,0.00914262,0.034318175,0.03740333,-0.08419527,-0.058775865,0.05503529,-0.013583409,-3.2072427e-33,0.096404545,-0.031104872,0.003908315,-0.074992254,-0.05232831,-0.0033025458,-0.013029228,0.07772856,-0.030794138,-0.02178522,0.055665195,0.025958339,0.091379866,0.012117087,0.04176977,-0.025583586,0.059081353,0.055257823,-0.032568347,0.0025230632,-0.007906445,0.008446047,-0.06656453,0.005479411,0.025098665,0.06309726,0.019562494,0.08771458,0.02322503,0.022454757,0.016802827,0.024906838,-0.039937347,-0.016771624,0.017705645,0.024514886,-0.06325071,0.002998431,-0.00092483533,-0.027556565,0.04716223,0.029188182,0.0006137314,0.010402182,0.09521981,-0.011818881,-0.0791617,0.0025264649,-0.07691661,-0.029537447,0.05870637,-0.0029412669,0.030184451,-0.06855708,0.019279663,0.030350415,-0.021180268,-0.013010456,-0.0012509521,-0.050248858,-0.08769721,0.048175935,0.07779846,0.05457327,-0.025034152,0.03338643,0.0025931816,0.05876479,0.0371272,-0.05166475,0.07859788,0.07183899,0.03243288,0.02982337,-0.045294836,-0.094693296,-0.047703948,0.026919847,0.031141143,-0.03961581,0.06194538,-0.067218155,-0.018442271,-0.06856393,-0.037387658,-0.031420585,-0.006502754,0.044927657,0.011616291,0.01479489,0.011960163,-0.06054506,-0.04058847,0.09959032,0.044362117,-2.9778688e-08,0.0031497423,-0.036373153,0.0736608,0.005553772,-0.04582964,0.032410245,0.0061003068,-0.02304661,0.058573272,-0.020737458,0.024846407,0.057006948,0.035222515,0.062937714,-0.022107167,0.0052476027,-0.040959038,-0.017305408,-0.03758889,0.018359505,-0.09036286,-0.05568903,-0.100167,0.07359544,0.083269835,-0.015947372,0.0035830303,0.008616966,0.022547152,-0.028705373,0.021941174,0.053226452,-0.005068784,0.042912498,-0.00054316403,0.020275675,-0.029064655,-0.06702493,0.043456398,0.060161415,0.013783365,0.045569994,-0.12688766,0.006337445,0.061251562,0.019964043,-0.04771346,0.034954853,-0.06603534,-0.05647323,0.028528016,-0.029718736,-0.05161237,0.005168002,-0.10269196,-0.017421415,0.014425684,0.059273325,-0.028218025,-0.021013977,0.101073,0.026380103,0.17911384,-0.048323408 +6.2.1.59,"The enzyme, present in pathogenic species of mycobacteria, participates in the pathway for biosynthesis of phthiocerols. It catalyses the adenylation of the long-chain fatty acids arachidate (C20) or behenate (C22) [1] and potentially the very-long-chain fatty acid lignocerate (C24) [2]. The activated fatty acids are then loaded to EC 2.3.1.292, (phenol)carboxyphthiodiolenone synthase.",384,1.0,-0.053989902,-0.0019342592,-0.06763624,0.03492949,0.027958427,0.04530311,-0.049560152,0.046935648,0.015986115,-0.0083140265,-0.024828792,-0.10370578,-0.025163054,-0.02709401,-0.05807945,0.041748784,-0.03409551,0.057615366,-0.0064453115,-0.01351247,0.06396653,0.06336202,0.015754135,-0.03225867,-0.0034043333,0.008435517,0.08583037,-0.0057997997,-0.03316228,-0.06454466,0.025429778,-0.11702918,0.067886256,-0.052353222,0.05649525,0.09673998,-0.028727459,-0.1389508,0.10640206,0.005448437,0.05826257,-0.023065064,-0.028922748,-0.01035155,-0.04482898,0.012044886,-0.057712033,0.05850855,-0.027984483,-0.07620742,-0.080007456,-0.037168797,-0.07935643,0.0014240282,0.015838914,0.051762428,-0.009715035,-0.004697387,-0.016215838,0.06989334,0.063165076,0.0028191519,0.0075719985,0.042257827,-0.051058788,-0.04509306,-0.03771641,-0.038955,0.048002698,-0.03234788,-0.08394685,-0.020872254,-0.010683233,0.07460367,0.030999064,0.0031885884,-0.0053874534,-0.019245913,0.01202539,-0.0312577,-0.027302528,-0.068156466,-0.03577135,-0.03762314,0.054706518,-0.04527523,0.09494488,0.036627736,-0.005674365,0.11216253,0.11033873,-0.06395064,0.011759162,-0.04393462,-0.07350072,-0.013228709,0.08499954,-0.0002797617,-0.01082818,-0.04686162,0.009676553,-0.030507525,-0.044880413,-0.06672728,-0.048565343,0.015766162,-0.039106786,0.05389827,0.047792733,0.037464123,-0.024203714,-0.014818136,-0.0005732821,-0.033996128,-0.04219261,0.10892176,0.036391575,-0.07839107,-0.050700687,0.061447825,-0.012916389,-0.10761306,0.018484231,0.020554608,-0.10804934,-0.0024170196,-0.07708057,2.3049374e-33,0.03760974,0.0031327917,0.0049511953,-0.011148749,0.04601835,-0.026032614,-0.10912528,-0.00020858913,-0.044743117,-0.10814534,0.005571863,-0.083396785,0.004305446,0.03856594,-0.060428,0.03682152,-0.07251868,0.050415587,0.07792353,0.06305792,-0.014524516,-0.055163465,-0.0021893273,0.013436362,0.021330446,0.10955369,-0.05399239,-0.0062102727,0.053256128,0.025644088,0.04264033,-0.07177682,-0.095332615,-0.017995408,0.022108385,0.010797794,0.0030557583,-0.101689294,0.014820142,0.018732691,0.0024037615,-0.052155156,0.02342452,0.009038694,0.04557822,0.0013645294,-0.030488173,0.071728565,0.0010469028,0.045435045,0.049004987,-0.078993276,0.0744393,-8.902669e-05,-0.06803001,-0.029741412,-0.054864027,-0.03557513,0.01678783,0.032856464,0.08752811,0.11874212,-0.020410646,0.09869626,-0.047065344,-0.028701358,-0.06368335,0.026984941,0.02347545,0.068432935,0.01995778,-0.0631652,0.0825189,0.02161928,0.043943983,0.0056660813,-0.10104646,-0.05785807,-0.044439904,-0.035339233,0.073254764,0.04314639,0.0050764186,-0.020779783,-0.0025866118,0.004288989,-0.11261412,-0.03230031,0.009955536,0.016349582,0.022396715,-0.085201494,-0.041628223,0.06450565,-0.083754964,-4.3905618e-33,0.12390115,-0.09601662,0.066724375,-0.08102756,0.0057219253,-0.0042822836,0.030999565,0.014500696,0.055707026,0.024756894,0.07454301,-0.031716365,0.04895857,-0.026963387,0.0029625003,-0.02045868,0.036188107,0.013416655,-0.052137066,-0.043835945,0.03874692,-0.0032064992,-0.018303461,0.041133996,-0.002573855,0.009144581,-0.027855407,0.08749362,0.028194418,0.085657485,0.02010882,0.006566167,-0.057074856,-0.09181726,-0.024909561,0.046182767,-0.083261,-0.03292069,0.059458956,0.020502351,0.015198218,0.0065539205,-0.022520231,-0.01081907,0.012984745,-0.0052525955,-0.033552714,0.024044557,0.05255397,-0.09961548,-0.025507538,0.030190732,0.0143205505,0.03873412,-0.008210367,0.08378372,-0.010998096,-0.014327753,0.016785685,-0.057578254,-0.105143026,-0.044203956,0.07752654,-0.014892267,0.04148054,0.044930656,0.034382805,0.07814499,0.06667044,-0.0454148,0.057705212,0.023877298,-0.021750778,0.08064151,-0.09396308,-0.021556536,0.002047896,-0.031126749,0.008974161,0.019176038,0.0034007893,-0.015973993,0.02937703,-0.119222045,-0.013735363,-0.085540116,0.021037864,0.11217558,-0.039741036,0.046722468,0.014524384,0.06602566,-0.054444585,0.02035241,0.019452719,-4.2871708e-08,0.020997852,-0.06955679,0.06334491,0.0010644561,0.05810578,0.032955527,-0.015480238,-0.022834577,0.04892579,-0.038454596,0.005157961,0.029567681,0.043493524,0.0060444907,0.050054055,0.07474275,-0.077703424,-0.031368263,0.009943831,-0.024928443,-0.08500828,-0.026337076,-0.02789872,0.0038607689,0.043104295,-0.0530936,0.020870302,0.064603075,-0.0070135314,0.038081985,-0.009347408,0.036301505,-0.00023904527,-0.0020733003,-0.011143407,0.0009355022,-0.090857536,-0.02879006,-0.05356629,0.04602211,0.09202497,0.024532158,-0.037768975,0.050603908,0.006802776,0.032804742,-0.024381015,0.019105438,0.014238531,0.04555167,0.02323736,-0.0015762671,-0.049267624,0.006959839,-0.037343707,0.024904985,-0.042070262,0.017666504,-0.075924136,-0.024021592,0.04707609,0.061244063,0.18232547,0.012128182 +6.2.1.60,"The enzyme, characterized from the bacterium Pseudoalteromonas sp. SANK 73390, catalyses the CoA acylation of pseudomonic and marinolic acids, as part of the biosynthesis of thiomarinols and related compounds.",384,1.0,-0.0773503,-0.029314104,-0.13327375,-0.021600531,0.054541714,0.058440223,-0.11679244,0.05338543,0.027553968,0.013772539,0.00999476,-0.09497373,-0.0631996,0.04113061,-0.0492806,0.031765614,-0.08543727,0.008443235,0.0646644,-0.025692256,0.05370079,0.08468748,-0.08175408,0.018374942,0.058297195,0.05274316,0.04759843,-0.015239345,-0.0025065457,-0.02338342,-0.052572776,-0.032832213,0.05283609,-0.052595776,0.063035525,0.07143937,-0.055500306,-0.04100189,0.093691535,0.033925172,0.03882821,-0.082219504,-0.009042396,0.0034621202,-0.0854272,-0.015589547,-0.0070580863,0.086149104,0.021877635,0.0061777616,-0.106084086,-0.007369789,-0.06566689,0.05349302,-0.017325219,0.054136828,0.006956643,-0.03579429,-0.026933447,0.00029171514,0.06612808,-0.005749243,-0.065127045,0.041392744,0.008530779,0.026502714,0.013087444,-0.04216249,0.05060097,-0.010114332,-0.017065307,0.0013043722,0.022025077,0.056367755,0.003392092,-0.060687497,-0.007645941,-0.03680151,0.013586896,-0.041009612,0.008020441,0.032152046,-0.017082492,0.09120452,-0.011323849,0.01713424,-0.0112855835,-0.010476042,0.046154927,0.0076579475,0.073718436,-0.0054503763,-0.0037011388,-0.083668426,-0.03761924,0.1348793,-0.0013778905,0.0115278065,0.08469967,-0.039843775,0.03155583,0.04396159,-0.08124725,-0.08675736,-0.04695854,0.02568256,-0.040250223,0.06481585,0.011061996,0.03778995,0.02675614,-0.0032571252,0.007542381,-0.058531668,-0.034820206,0.07686932,0.016368333,-0.08711853,-0.031987317,-0.026269026,-0.013756236,-0.03298607,0.025937619,0.083904676,0.04741724,-0.004649112,-0.13651116,2.211566e-33,0.09072196,0.06766439,0.04435782,-0.090565465,0.0070168753,-0.050334904,-0.045594644,0.045495678,-0.03262743,0.0058974093,-0.035403218,-0.026608383,-0.024344083,-0.046669073,0.01004328,-0.053050734,0.011049295,-0.015307267,0.004069385,0.038407084,-0.0006962555,0.09370903,-0.022105832,0.07230488,0.023522148,0.05752023,0.029605113,0.058147173,0.041547466,0.02523685,-0.020856798,-0.05720246,-0.067349896,-0.023948886,0.072173044,-0.103072464,-0.077607386,-0.006097739,-0.006085797,0.11134066,0.050055727,0.018842977,-0.010080615,0.002125534,0.051453143,-0.0677316,-0.011658136,0.104440615,0.058700092,0.02341739,0.017818218,-0.0181268,0.05723968,-0.01570011,-0.052033402,0.017482726,-0.04553258,-0.02304095,-0.014197846,-8.453286e-05,0.03476699,-0.012676006,0.021916298,-0.013640563,-0.04577316,0.0065256665,-0.062170777,-0.030944562,0.051653128,0.021209184,-0.039962143,-0.004975413,0.026721878,0.03628809,0.07097436,-0.018296773,-0.0016190076,0.009405599,0.008058161,-0.032540783,-0.039505355,0.015545333,0.034034338,0.012908081,-0.024530781,-0.01173964,0.0011876439,-0.05099704,-0.014311471,0.054519914,-0.004695961,-0.07028436,-0.027105572,0.030278424,-0.058176916,-2.9947162e-33,0.08822431,-0.13184355,0.0049103885,-0.05920634,-0.060218066,-0.010948749,-0.06199856,0.054697677,-0.0057401834,-0.0030170875,0.09766486,0.05547199,0.022087997,-0.075952396,0.008627273,0.040853422,0.116416536,0.019350024,-0.058048416,-0.00770705,0.024540482,0.07312753,0.020113198,-0.034622617,0.07883033,0.03383629,-0.014103651,0.09112214,0.010118832,0.13855669,0.022762457,0.016580323,-0.050449066,-0.03220605,-0.04272615,0.06609095,-0.023324167,0.03858799,0.02098763,0.035337836,-0.022675784,-0.010709292,-0.00073059235,0.019490957,0.018287085,-0.017328542,-0.08271516,-0.05104037,-0.022774765,-0.15021631,0.010878634,-0.0047254586,0.018430162,0.03354924,-0.035141375,0.060040247,-0.037926123,0.044745848,0.07346283,-0.06801591,-0.013312139,-0.082810245,0.0072355033,-0.06527901,0.0618347,0.039022785,-0.08173556,0.044069756,0.009146048,0.00781203,0.037340034,0.07271385,-0.014493826,0.081393525,-0.011685073,-0.0025040903,-0.02412854,-0.04273705,-0.03337369,0.03231689,-0.029120393,0.0054446543,-0.02867534,-0.09506853,-0.09078442,-0.041402668,0.074377865,0.07849017,-0.07632217,0.07114213,-0.015216091,-0.005679844,-0.004082722,0.11327134,0.056519777,-3.2109885e-08,-0.0008718374,-0.054114234,0.017671064,-0.03148613,0.024943352,0.016963838,-0.025732646,-0.04673295,0.041819736,-0.07052879,-0.09007572,0.033235986,0.048540767,0.038931694,0.040558364,-0.044249848,-0.019936755,-0.0038590876,-0.051681973,-0.01028984,0.014540111,-0.009278993,-0.07588887,-0.0028846657,0.005811249,-0.020107444,0.074899524,-0.058781322,-0.010687233,0.05042031,-0.053381033,0.04133841,-0.002686592,0.008744529,0.009509418,0.052040257,-0.0049612657,-0.06528751,-0.064328246,-0.032229695,0.066876024,-0.009953118,-0.13232878,0.08316535,0.042052954,-0.053778164,0.012712341,0.0810861,0.0068616453,-0.02225214,0.053661887,0.025998995,-0.061113384,-0.02566105,-0.062374804,-0.05859856,0.020478534,-0.028967112,-0.11346851,-0.012850197,0.011532243,0.03241593,0.18306632,-0.05451011 +7.2.2.21,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants.",384,0.99999994,-0.038827315,0.010527346,-0.0314211,-0.036208104,0.013588728,0.019046554,0.016918369,0.024929387,0.07413789,0.029788608,0.06415282,0.006394771,-0.07585273,0.11500084,-0.05178582,-0.06430541,-0.038233142,0.045798514,0.10159594,-0.051671103,0.099451736,0.07255003,0.0024910339,0.030915724,-0.0396579,0.0009051462,0.029109756,-0.029796218,-0.041149653,-0.034930754,-0.1511805,0.022338312,-0.010897528,0.0050487104,0.011387634,0.15417743,-0.06552311,0.018901737,0.054215916,-0.041226752,0.16616443,-0.06605225,0.007706685,0.037388634,-0.07144407,-0.0075225867,0.021830553,0.02566627,0.027501699,-0.06711641,-0.021555863,-0.055408757,-0.041356996,0.013282699,-0.054292113,0.02942222,0.0070098224,-0.0004543226,-0.0237808,-0.019855741,-0.029626276,0.00030070834,-0.0072641377,0.06228446,0.06749832,-0.043933783,0.046108175,0.04203154,0.006935688,-0.046260986,-0.038867712,-0.016066447,-0.030421535,-0.007052445,-0.017186692,0.027893735,-0.042760324,0.032536525,-0.018111173,-0.031726416,0.05958742,0.008404636,-0.035873145,-0.018982215,0.058251083,0.00870538,-0.0035699029,0.017361028,0.030982966,-0.029144691,-0.027613482,0.008547338,-0.0093933055,0.017847456,-0.12910466,0.044762522,0.06310263,0.0205942,0.064898826,-0.025167458,0.07358551,0.064035475,0.03784717,-0.0038079766,-0.01872156,0.017793791,-0.051810395,-0.031163355,0.015900576,0.06352409,-0.07266099,0.014712624,0.047190033,-0.05275022,0.035298765,0.05263533,-0.051651824,0.017798012,0.004153923,0.033388693,-0.061485924,-0.08004886,-0.019557323,-0.0051259687,-0.021942459,0.06006251,-0.06221396,-1.9655797e-33,-0.0009655202,0.002045216,0.048849136,-0.009977472,-0.0089313155,-0.01880935,-0.040284563,-0.061374463,-0.054245044,-0.14999723,-0.056108713,-0.053414173,-0.00840262,-0.004353076,-0.014466491,-0.024477249,-0.043175746,0.042123616,0.124572635,-0.0042714956,0.018647226,0.027829554,-0.057624076,0.04566036,0.037174884,0.028967531,-0.011901166,-0.022533065,0.040654134,-0.012138964,0.042391546,-0.06305077,-0.09120772,0.015476643,0.0034566324,-0.06304896,-0.055194903,-0.020612324,0.025856784,-0.062911585,-0.09980354,-0.06011099,-0.0030164716,-0.02114681,0.02261884,-0.061931882,-0.07001667,0.063590124,0.004293855,0.06515417,0.048201755,-0.07926815,0.11874598,-0.013682302,-0.065079935,-0.018263722,0.011408975,-0.019959142,-0.017839976,0.026698519,0.09446337,0.10544236,-0.029442031,0.011371418,-0.014874717,0.04261743,-0.115726404,-0.08867347,0.04562467,0.105508864,-0.06349363,-0.014066157,0.003912063,0.026303113,0.05137099,0.017261362,-0.012357556,-0.02721103,-0.050880644,0.06950322,-0.0223908,-0.06647134,0.02539137,0.025220864,-0.054809235,-0.02342425,0.0045120255,-0.030661538,-0.008883744,-0.023987694,0.10025331,0.0023490887,-0.010635027,0.08453553,0.053473562,-1.6898981e-34,0.15668294,-0.024290549,0.102537744,-0.063516185,-0.0493667,0.0032409828,-0.002293263,-0.007744713,0.008293802,-0.009914192,-0.03218647,-0.018024016,-0.0030398564,-0.035269033,-0.0024025668,-0.051407013,0.008793967,0.0798753,0.049523372,0.03573484,0.007651434,0.08882402,0.011387747,0.037076563,0.014128437,-0.044041764,0.00043337527,0.07533844,-0.036409836,-0.007305018,-0.010201909,0.03259494,-0.018795228,0.008255238,-0.0746201,0.011063751,0.009042939,-0.012671913,0.018079653,0.061869863,0.057996973,0.049731947,0.062066957,0.052219775,0.03321084,0.03423007,-0.022919755,0.032575503,-0.015320301,-0.026763653,-0.00032367694,0.098221205,-0.06625676,-0.009539585,0.07304807,0.05351221,0.029839536,0.04257565,-0.022429211,-0.059071753,-0.047444843,-0.10836601,-0.0067188484,0.031826567,-0.014773023,-0.0035423732,-0.013635406,-0.010688752,-0.005273275,0.069537796,0.049703322,0.12967259,-0.051570803,0.027797796,0.010886665,0.0095640365,-0.0019201039,-0.0137765,-0.02541287,-0.008020424,-0.046530083,0.047087103,-0.004800761,-0.06689257,-0.024370166,-0.10258649,-0.0003676096,0.0032607373,-0.013233443,0.017729051,0.01436039,-0.03669448,-0.016826602,0.020983113,0.020396788,-2.3517941e-08,0.022149827,-0.00035220452,0.073682696,-0.08975652,0.032038003,-0.0039974498,0.0496906,-0.010808308,0.119977735,0.0025103048,-0.039367046,0.024254803,0.085279144,0.0070742094,0.09795287,0.067741066,-0.036171094,0.0458239,-0.05021337,-0.040960263,0.006779689,-0.04194632,-0.16100168,0.121211275,0.055443257,-0.023030791,0.041961867,0.04579823,-0.048623268,-0.06264523,0.015201223,0.010259845,0.029053662,-0.04892178,-0.037671346,0.06777117,-0.048407406,-0.0011829844,-0.06849366,0.022212202,-0.030750047,-0.06318034,-0.042742766,-0.008272213,0.017625915,0.049399804,0.014507688,0.021853793,-0.020994272,-0.014829738,0.052914556,0.02525543,-0.030742848,-0.13139662,-0.102050096,-0.013343741,0.018130276,-0.053571057,-0.037794326,-0.06823024,0.053593576,0.0017136827,0.15758242,-0.058122598 +1.1.1.420,"The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose.",384,1.0,-0.010717851,-0.049822982,-0.011911123,-0.03040062,-0.017747216,0.00010416002,-0.07669161,0.02012189,0.035755288,0.07740424,-0.0058297324,-0.031696104,-0.042020656,0.082912594,-0.02210022,0.043449588,-0.084883094,0.031416588,-0.032128934,-0.009902853,0.10729442,0.052869167,-0.012106387,-0.06035086,0.03928096,-0.03481488,0.097833104,-0.022893658,-0.05446615,-0.046231274,-0.025056941,-0.046470374,0.03025056,-0.004232167,0.07550718,0.045013174,0.026931433,-0.037550174,0.06979521,0.0002979943,0.0018248165,-0.01211736,0.010437837,-0.014509574,-0.069328904,0.014629447,-0.07254768,0.020688102,0.012070894,-0.020146746,-0.051223747,-0.06265584,-0.038105544,0.007907252,0.046322744,-0.013994073,0.0018091127,0.01128746,-0.05245691,-0.062032823,0.068182275,0.01348,0.06940905,0.05410239,0.02082399,-0.040322073,0.009222289,-0.026207337,0.015828568,-0.081414975,-0.066444404,-0.10101094,-0.042791594,0.030849587,0.016673585,-0.031250432,0.044307943,-0.04927883,0.014138358,-0.094823495,0.047390208,0.055806044,0.024258235,0.10644971,-0.014648772,0.05180601,0.034623142,-0.037972912,0.042213142,0.013019836,-0.013808782,-0.06993193,-0.016979255,-0.086577676,-0.065138444,-0.018036421,0.0132194385,0.015465527,0.027334405,-0.0383427,-0.051050585,0.08654528,-0.02624758,-0.060548257,-0.05653179,-0.0024408116,-0.021349544,0.0729144,0.022864882,-0.03323822,0.03825701,0.021634515,0.069731735,0.078542136,-0.030713027,0.044235587,0.023645664,-0.050945632,-0.019512856,0.0149498535,0.004109745,-0.04993793,0.057325944,0.07167553,-0.044917382,0.03938547,-0.05100519,-3.9938695e-33,0.07701653,-0.023794277,-0.030638412,-0.011090716,0.054700103,-0.06879065,-0.048186816,0.012923736,-0.11778397,0.018220795,-0.15511115,-0.1007017,0.036854904,0.05468623,-0.0045858747,0.022027943,-0.014177172,-0.0036069485,0.020038193,0.019473074,0.020169104,0.053896114,-0.009435582,-0.023028785,0.02476515,0.06042219,0.012546169,0.09858029,0.01398474,-0.027254311,-0.006783864,-0.1024362,-0.037233513,0.02785199,0.026910445,-0.019657854,-0.0072459285,0.020525083,-0.018132523,0.024871124,0.024905136,0.04629143,-0.008859157,-0.023136783,0.0394961,-0.0012132374,-0.0339609,0.07268619,0.010438631,0.08632905,0.092489235,-0.020120462,0.12285258,-0.038176153,-0.05616376,0.0071428623,-0.05646787,-0.029924996,0.0164776,0.03078253,-0.00479683,0.037105337,-0.06625272,0.08103661,0.03915977,0.014263465,-0.014566244,-0.01851812,0.024279056,0.090695165,-0.1187731,-0.010497617,0.047585413,-0.04230578,0.040251736,-0.076674886,-0.039990775,-0.024372483,0.042019125,-0.02130802,0.0077507054,-0.03755073,-0.027281096,-0.015982693,-0.072845206,0.009274025,-0.059099857,-0.09926928,-0.09184678,0.013841298,0.024215762,-0.04780377,-0.119405456,0.048047576,0.045484066,1.4279508e-34,0.0778154,-0.07032939,0.030871175,-0.077386804,-0.07655724,0.095090166,0.03670491,0.013066646,0.056751624,-0.0006645797,0.05303063,0.013489484,-0.017746104,0.0016793001,-0.003573258,0.042660024,-0.06777031,0.003554347,-0.044262774,0.020602323,-0.04851769,0.060449548,-0.04531839,-0.060517613,0.06152449,0.035554234,-0.018344866,0.12168652,-0.02840862,-0.030420186,0.108481854,-0.0045988,0.013682968,-0.048063364,-0.069774665,0.08812652,-0.03438365,-0.0049199252,-0.023329223,-0.00044240407,-0.05136399,0.003480292,-0.025555406,0.054521732,0.023885954,0.048342187,-0.085009284,0.03938795,-0.03643135,-0.028672645,0.004124278,-0.021775996,0.09065494,0.008005356,-0.008785739,0.0957443,0.03348529,0.05117546,-0.06483976,-0.003127295,-0.004184873,-0.08322043,0.11665395,0.07666103,0.022315245,0.0140080005,-0.018467838,0.008842762,-0.003223858,-0.010541085,0.022375239,0.0027057254,-0.042516734,0.002966779,-0.05382427,-0.09023432,-0.10948875,-0.035995107,0.046536103,0.06263136,-0.07107655,0.008004547,-0.008434132,-0.011111123,-0.043672547,-0.09514481,0.008956947,0.106147505,0.022168143,0.104298085,-0.035483494,-0.0016768256,-0.03466647,-0.033735033,0.067319535,-2.5831124e-08,0.08542653,-0.01929264,-0.01359266,-0.021792503,0.038532306,0.011132611,-0.058415875,0.05714077,0.02206284,-0.0017790925,-0.010178985,0.080340855,-0.048065282,-0.001675583,0.070747524,0.015285095,-0.010330647,-0.01811317,-0.041365676,0.045288663,-0.073043406,-0.023053698,-0.12849712,-0.010645281,0.063466996,-0.06115019,0.05639673,0.054209683,-0.040427893,0.0164932,-0.026698494,0.021653099,0.003605495,-0.085222244,-0.08002988,0.035508953,-0.044249337,-0.06906885,0.042407002,0.04021889,0.078987576,-0.002468166,-0.034184042,0.021645082,0.0027152158,0.055025183,-0.015074819,0.022938306,-8.507582e-06,0.026177434,0.0013389833,-0.007163909,-0.049714074,-0.047170505,-0.13254347,0.049410265,-0.032775667,-0.06215822,-0.013120193,-0.031864483,0.060498208,0.041190848,0.18664815,-0.057582177 +1.1.1.421,"The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. The reaction involves migration of a hydroxymethyl group from position 3 to position 2 and oxidation of the 3-hydroxyl group. Stereospecificity of the product, 3-oxoisoapionate, has not been determined.",384,1.0,-0.01850622,-0.05607501,-0.027389491,-0.08083516,-0.0068972465,-0.023841003,-0.09717378,0.0074022813,0.05646927,0.0328161,0.007926131,-0.047114152,-0.018586133,0.01656223,-0.030987442,0.09473898,-0.07020541,0.038282976,-0.03562455,0.0039668633,0.07732752,0.008704872,-0.0056955433,-0.031751987,0.059552122,0.051255636,0.02384228,0.023601213,-0.06609938,-0.097166635,0.007840952,0.02215387,0.03242989,-0.03439014,0.05146997,0.063290745,0.008521362,-0.025467891,0.10574618,0.01204513,-0.025622642,0.0072412277,-0.013960117,-0.031651735,-0.051235538,0.031726122,-0.08464723,0.012707119,0.004359162,-0.015556028,-0.034686923,-0.062617525,-0.03884098,0.04002413,0.017302148,-0.032502368,0.071123056,0.030233523,-0.04979843,0.021333676,0.0991493,0.03519422,0.04864255,0.023672538,0.016831465,-0.055022717,0.015879994,-0.080756284,-0.003910291,-0.047952898,-0.068993725,-0.103859745,-0.022873404,0.00066974305,0.014753115,0.015804227,0.032097675,-0.11494504,-0.008776801,-0.08926485,0.0560708,0.04395674,-0.018917885,0.113491595,0.0013369692,0.007392264,-0.005322808,-0.086567365,0.030176427,0.025438104,-0.0029575585,-0.0022203734,-0.03798913,-0.03427992,-0.026370835,0.016339026,0.007349313,0.042079877,0.044247296,0.014033171,-0.0343129,0.06311438,-0.0991382,-0.13282599,-0.048628658,-0.02066674,-0.027378226,0.06106338,-0.0052861595,-0.0128201265,0.015002606,-0.008955254,-0.00833678,0.04914996,-0.0755594,0.1153178,0.029732361,-0.029502755,-0.105791114,-0.041297846,0.015274523,-0.06887777,0.028454337,0.032962736,-0.047997642,0.027830698,-0.018779399,-2.3267714e-35,0.061814617,-0.022440368,-0.06569142,-0.016362017,0.033693686,-0.07673093,-0.059355713,0.024408307,-0.06037008,-0.051889278,-0.08551695,-0.038107507,0.013642929,0.005903683,-0.020245237,0.009303679,-0.0047583133,0.027860545,-0.021071227,0.0036016637,0.028954767,0.06143649,-0.05631067,0.017084027,-0.009437961,0.09150231,0.0104621155,0.050727997,0.024409927,-0.0053667547,0.0013445837,-0.121869236,-0.113726474,0.005218322,0.04108444,-0.013173036,-0.050429,-0.00596095,0.0013753771,0.06797728,-0.0037038017,0.056180824,0.0064042388,0.008224518,0.07988339,-0.00716818,0.014452939,0.1211986,0.03918591,0.03474218,0.020713754,-0.026413457,0.10137138,-0.0038606776,-0.029829811,0.011009048,-0.019489696,-0.03757757,0.02667471,0.0030055468,-0.013011506,0.030566992,-0.027783005,0.011666375,0.03942432,0.013173727,-0.045876462,-0.024693938,0.023796204,0.044623516,-0.040530358,-0.023067323,-0.014797555,0.02763195,0.021134343,-0.058141783,0.01196776,-0.0037483105,0.055784743,-0.06430781,0.016286854,0.017738752,-0.013342099,-0.047343805,-0.025141815,0.019000296,-0.027663903,-0.08953138,-0.056146316,0.05839056,0.042194337,-0.06439893,-0.107452564,0.014122165,0.013959182,-2.4832247e-33,0.038636293,-0.04871022,0.03657986,-0.089474596,-0.0707953,0.073183306,-0.031042552,0.13522892,-0.03795821,0.009546681,0.011418718,0.011627764,-0.01048315,-0.021761332,-0.0044478145,-0.0070070447,-0.0006780502,0.030575432,-0.045156173,0.017952532,0.019489208,0.1010618,-0.01573937,0.00096072425,0.023339506,0.03243247,-0.028398888,0.029653363,0.063582666,0.04283671,0.05039333,-0.010149007,0.0065761283,0.02103536,0.0077390806,0.12716745,-0.04439584,0.0044194325,-0.029756723,0.064561665,-0.0704661,-0.021639394,-0.019624034,0.032387935,0.09072782,0.0672236,-0.119956166,0.0521775,0.004331366,-0.015439694,0.059601247,0.01170493,0.054210026,-0.002219018,0.02952581,0.0671559,0.054324172,0.01942327,-0.029204732,-0.026625006,0.017862508,-0.08390678,0.0921332,0.007960456,0.017947497,0.12039542,0.008414326,0.06939932,0.016415399,-0.0019420248,0.09151597,0.013929519,-0.045657124,-0.03163974,-0.036714856,-0.08975076,-0.11497764,0.013581555,0.004409682,0.06036693,-0.052895952,0.020272661,0.029776668,-0.026001522,-0.050077062,-0.121820025,0.04744627,0.090562016,-0.06975008,0.069103666,0.025343489,0.009066727,-0.08424687,0.018489454,0.1212942,-3.7671423e-08,0.09531998,-0.026986504,0.08507224,0.001060997,0.0010012427,0.019137248,-0.009157384,0.052769464,0.07688919,-0.022755053,-0.050567586,0.098287284,-0.026087224,-0.022162529,0.044755243,0.000329555,-0.008515328,0.011397234,-0.058571406,0.04030815,-0.06941926,-0.0033159235,-0.059574284,-0.05342637,-0.0069722715,-0.04047648,0.068941146,-0.010090272,-0.028890017,-0.021377185,-0.0009216174,0.03792598,-0.008450431,-0.08444493,-0.10747382,0.029121688,-0.07975952,-0.06470221,0.0036181528,0.028866908,-0.027627204,0.013159125,-0.08614351,0.061639436,0.06377912,0.008727297,-0.0031877058,-0.0039039042,-0.035156187,0.025325572,0.03257996,-0.04515599,-0.0073400303,-0.074869536,-0.18294159,0.064310335,-0.045956064,-0.037637472,-0.03030104,-0.03264509,0.019250624,0.026783757,0.17550129,-0.019019224 +1.1.2.10,"Isolated from the bacterium Methylacidiphilum fumariolicum and many Methylobacterium species. Requires La3+, Ce3+, Pr3+ or Nd3+. The higher lanthanides show decreasing activity with Sm3+, Eu3+ and Gd3+. The lanthanide is coordinated by the enzyme and pyrroloquinoline quinone. Shows little activity with Ca2+, the required cofactor of EC 1.1.2.7, methanol dehydrogenase (cytochrome c).",384,1.0,0.012212815,-0.06453061,-0.11307175,-0.069204755,0.049110763,0.03116759,-0.087635346,0.011952852,0.074217476,0.014609213,0.07503954,-0.14664099,-0.0021219915,-0.04314115,-0.04167654,-0.011239339,-0.027081462,-0.012617866,0.007468443,-0.00920338,-0.019390292,0.030896733,-0.020265155,0.0001858181,-0.05053525,0.03397617,0.0055040317,-0.022103595,-0.019460283,-0.022784129,0.04656128,-0.0025815193,0.077747464,-0.05008961,0.038746182,0.083063595,-0.098780274,-0.050195828,0.02828187,0.028585406,-0.0019107255,0.04852381,0.04831937,-0.023258276,-0.037942044,-0.021493139,0.00043420258,-0.021101912,0.027963039,-0.020792963,-0.016376348,-0.046866417,-0.01801576,0.0863575,0.00042401848,0.02607415,-0.0073963283,0.00040366297,-0.03963624,-0.0021529987,-1.1510079e-05,0.030694582,0.08269321,-0.058612112,-0.018759057,-0.0052081826,0.0033676045,-0.10992843,0.041652262,-0.019312328,-0.08628476,-0.06877671,0.048650883,-0.014757612,-0.021333901,0.11085317,-0.011331244,-0.06853455,0.014754418,-0.09392314,-0.046879657,-0.025592675,0.012780327,0.06430413,0.071060166,-0.020041553,-0.020506505,-0.032831073,0.01477633,0.05512346,0.036012672,0.09726628,-0.032029245,-0.05423313,-0.050779086,0.04632296,0.025083743,0.06381831,-0.021160685,-0.026805842,-0.016554657,0.091466345,-0.08150522,-0.09797266,-0.124118686,-0.028395783,-0.003851758,0.051871307,-0.04887283,-0.04500158,-0.01201319,-0.0065577147,-0.04752541,-0.06850663,-0.031688247,0.09590565,0.1560573,-0.08310011,-0.048930157,-0.06561707,-0.0059308093,-0.055157855,0.116972804,-0.03268122,-0.020861417,-0.004730471,-0.049483083,6.746673e-33,0.090872556,0.008160506,0.009193507,0.006235757,0.026354115,-0.05171559,-0.08373569,-0.016274631,-0.021448158,-0.08674947,-0.021613458,0.024299532,0.04803664,-0.05648014,-0.031429578,0.010422816,0.012783781,-0.041244682,0.06903946,-0.10280942,0.05194629,-0.0122969635,0.02767526,0.017197084,0.049824696,0.05044287,0.02539558,0.029728001,0.0128429225,0.014978489,-0.0058060866,-0.08683172,-0.105407245,-0.043774184,0.04570283,0.11842736,-0.13426489,0.014336517,-0.039932888,0.07721571,0.017323744,0.050730173,0.10964742,-0.080473185,0.028008899,0.026847456,-0.025481183,0.09837474,0.10682812,0.094484024,0.0318785,-0.05468644,0.101661205,-0.013398598,-0.08018243,0.000109606466,-0.015582683,0.034308814,-0.008370354,0.04202534,-0.0064601623,0.087049775,-0.031821437,0.057939872,0.025390882,0.016698306,-0.10060295,-0.026440272,0.011566615,-0.014477324,-0.032747258,-0.016320728,0.09018798,0.046607506,0.04112763,-0.0047248853,-0.0864738,-0.03655742,-0.0074397963,0.011243182,-0.00032227114,-0.018197501,0.04355957,-0.020743927,-0.004875147,0.028387865,-0.088806435,0.0334391,0.013378307,0.037300542,0.019555604,-0.05010551,-0.0061135823,0.05993027,-0.023739673,-6.175964e-33,0.026537746,-0.06237013,0.045874216,-0.05192386,-0.02093652,0.1091595,-0.032554645,0.03906574,0.031847287,-0.03557328,0.11764391,0.041517813,0.04179165,-0.048057612,-0.003936601,0.010191601,0.06179303,0.068372175,0.028931912,-0.011183146,0.028451597,-0.0016661959,-0.04495689,-0.015935095,0.050786566,0.0920722,0.035607815,0.041682273,0.027527193,-0.0016855095,-0.0016576381,0.08604248,-0.01671848,-0.07786457,-0.053070616,-0.056667916,-0.055249434,-0.062364466,0.03786358,0.058358535,-0.025668278,0.06435441,0.07136625,0.029714504,0.047415193,0.043526314,-0.065118976,-0.027419623,0.0024621733,0.07660038,0.042250615,-0.06472518,-0.05605899,-0.014925919,0.08434041,0.078619465,-0.0034343249,0.07148623,0.0004038136,-0.048533402,-0.0070241503,-0.005456582,-0.018508978,-0.00019882523,0.008236866,0.07340512,-0.013880778,0.08934434,0.018620363,-0.03176431,0.049358454,0.044136852,-0.016260684,-0.016245654,-0.020763552,-0.017890071,-0.031042447,0.07200195,0.034402348,0.030197605,0.06792802,-0.033939127,0.04068579,-0.02840251,0.021549923,-0.03143892,-0.033499386,0.03754066,-0.031967092,-0.013449034,-0.092199855,-0.008348067,-0.05213499,0.040674154,0.07713454,-4.708266e-08,-0.0018647196,-0.031252433,-0.014310427,-0.03249779,-0.01723919,0.022866234,0.03198252,-0.0018450209,-0.004793577,-0.049674362,0.04429438,0.05518607,0.015043234,-0.024629612,0.014733037,0.032574166,-0.021561544,-0.03677293,-0.026737886,0.019062512,-0.055201877,-0.019173115,-0.04701008,0.014025194,0.04343614,-0.008816438,0.031137206,-0.048163608,-0.06923567,-0.010507598,0.008327072,-0.019266643,-0.01805229,0.005770936,-0.08693824,0.0020594012,-0.045296017,-0.035771634,-0.041922476,0.08635557,0.01456364,0.007842856,-0.117686056,0.029183874,0.03341461,-0.005609224,-0.037391186,0.09271055,-0.10212492,-0.028440973,-0.009300198,-0.043318674,0.027991759,-0.019377597,-0.096284375,0.0059137084,0.05269513,-0.04671954,-0.07918343,-0.047207657,0.053473484,-0.07249732,0.1129568,0.054252207 +1.2.1.103,The enzyme participates in an L-lysine biosynthesis in certain species of archaea and bacteria.,384,1.0,-0.051304277,-0.09156102,-0.09296039,-0.0068004527,0.13056126,0.04260152,-0.11783411,0.00091143686,0.04500751,-0.006084805,-0.015995568,-0.06134733,-0.018300822,-0.022106787,-0.04420278,0.065253735,-0.12656419,-0.02902155,0.010366207,-0.022037502,0.10235324,0.104976185,-0.062279288,0.033520564,0.011019444,-0.053125508,0.058546346,-0.075906254,-0.04913922,-0.01982731,-0.006948856,-0.0834792,0.09162292,-0.08296936,0.04195916,0.08889372,-0.05761163,-0.06775769,0.12173815,0.005785,0.01997205,-0.03281244,0.009796526,-0.04341858,-0.06830603,0.045240432,0.038503278,0.0059457165,0.006695255,0.0393029,-0.01710791,-0.023047222,-0.07372558,0.012879114,-0.042274036,0.022054624,-0.07114095,-0.018445123,0.026834732,-0.0054490427,0.046185777,0.059831485,0.042097885,0.03727133,0.0114609925,-0.09423617,0.029433934,-0.028108642,0.056452643,-0.10177463,-0.0294854,-0.0876844,0.0039538876,0.048868444,0.028758394,0.024643848,0.017859975,0.007652482,0.010714966,-0.026506219,0.025074067,-0.058411736,-0.012170636,0.07170096,0.032216106,-0.07220181,0.019726897,0.06920877,0.07425312,-0.024865383,0.064333394,-0.071277685,0.0008283155,-0.028066305,-0.03888155,-0.020696113,0.047733236,-0.015628537,-0.039376423,-0.04262309,-0.03454412,0.019742114,-0.0036481454,-0.041838817,-0.048791546,-0.045138538,0.009184864,0.10703529,0.009577702,-0.04771349,0.06761074,-0.0036746613,0.07792334,0.060428683,-0.0016510782,0.05858329,0.0528394,-0.081796266,-0.087810315,0.032969885,0.018965797,-0.0007246257,0.07778927,0.06949902,-0.07435188,0.08470097,-0.12344852,-1.6748455e-33,0.07101188,0.023167677,-0.019692298,-0.06688483,0.04549391,-0.016451806,-0.070769235,-0.01587535,0.004695275,0.0043465286,-0.065374896,-0.07027512,0.08918962,-0.005416571,-0.049075842,0.055074364,-0.022545572,-0.04156425,0.014089035,0.07065529,-0.041564025,0.037003383,-0.004491991,0.054915674,0.028648458,0.025658734,0.06824377,-0.0141761545,0.01746722,0.0074438606,-0.022532964,-0.15698588,-0.051962484,-0.020364776,0.108143464,0.008812248,-0.02128994,-0.056669768,-0.022440368,-0.02645453,-0.0052731503,0.058915753,-0.020103553,-0.033352084,0.039881237,0.020862011,-0.029299418,0.09841435,-0.03296042,0.05751395,0.06432066,-0.05973084,0.06692106,-0.027960328,-0.0905739,0.0010570141,-0.05132419,0.0018609571,0.03363553,0.041224845,0.028236073,0.07290817,0.03673925,0.06889243,0.018909365,-0.024975773,-0.005410927,-0.009426833,0.002008046,0.028814713,-0.05293781,-0.07856106,0.077612534,0.006386478,0.003449923,-0.04102367,-0.06717637,-0.048668616,0.011002664,-0.009559254,0.020648258,-0.053677913,0.010946034,0.024783166,0.011618533,-0.023941316,-0.029440174,-0.039929546,0.005563523,-0.0069574495,0.025819654,-0.055548906,-0.003725825,0.057896037,-0.056900334,-1.0340906e-33,0.051567312,-0.14545023,0.04867504,-0.07567467,-0.026847672,0.043296367,0.011105331,-0.023064855,0.019915182,-0.032187905,0.058678746,0.01481965,-0.017525585,-0.050159313,0.04943373,-0.015883403,0.05609355,0.019439455,0.022100333,0.042656727,0.064001076,0.007503163,0.026718332,-0.022765934,0.06501444,0.012422509,-0.016489439,0.11094834,0.015090774,0.001789746,0.010759082,0.021556767,-0.028227475,-0.10557716,-0.04643675,0.055822786,0.0023658306,-0.034133006,0.066680804,-0.011699225,0.034076303,9.902977e-05,0.010065074,0.054358263,0.012455059,0.015860282,-0.041230068,-0.012585528,-0.005125727,-0.07420071,-0.004241999,-0.07275967,0.061627425,-0.0031237653,-0.017126184,0.024004415,-0.030886536,0.113417745,-0.02645295,0.012181212,-0.029735958,-0.06856157,0.008883254,0.026234593,0.0006813999,0.027129814,-0.0453,0.045940623,0.0065754936,-0.02401244,0.10034386,-0.002689429,0.060378257,0.11489122,-0.033831783,-0.017576983,-0.06701885,-0.120869085,0.034696966,-0.041343685,-0.04886525,0.011732698,0.0410383,-0.060577486,-0.037379842,-0.10075891,0.038566798,0.11925713,0.0342987,0.011738301,-0.005691744,-0.046152085,-0.04400362,-0.033210475,0.091217615,-2.3425038e-08,0.045629654,-0.043589327,0.049800526,-0.020831514,-0.055868227,0.031882007,0.023472102,0.031127496,0.00037506528,-0.032160886,0.037341785,0.035416488,-0.014377692,-0.020407172,0.02258412,0.08708001,-0.042379595,0.07124684,-0.045871843,0.022507142,-0.008872851,-0.0026168048,-0.043834962,0.008430439,0.024738746,-0.07228507,-0.022386527,-1.9107942e-05,-0.014200141,-0.06703499,0.025822762,0.0037574335,0.027119348,-0.058854103,-0.10375335,0.019720647,-0.06387509,-0.06151942,0.04443867,0.019084258,-0.03696118,0.050578736,-0.08379264,0.024965165,0.019201161,0.02675632,-0.0054691215,0.045264304,-0.0087300055,-0.009696407,0.06094616,-0.050183225,0.025290454,-0.05670259,-0.03024341,-0.0226009,-0.03711778,-0.038504258,0.0019435814,-0.057310205,0.0037791247,0.066926554,0.17867929,-0.06979712 +1.3.1.121,"The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 1.3.1.12, prephenate dehydrogenase.",384,1.0,-0.077294834,0.018481893,-0.14688906,-0.04452929,0.011858117,0.037291575,-0.054142788,0.062063847,0.08024517,-0.035300694,0.0071897046,-0.03198581,-0.012862818,0.046363294,-0.0491058,0.010854803,-0.101060174,-0.004900852,0.020343602,-0.060902297,0.118597806,0.06668725,-0.04749287,-0.0080302255,0.06569699,0.05350235,0.03042298,0.02032441,-0.024986852,-0.028830804,0.0369566,-0.054136228,0.1014794,-0.052349113,0.08988796,0.09508239,-0.0848735,-0.07522789,0.13652295,0.045849647,-0.0040411497,-0.005287285,-0.07251376,0.030751603,-0.08188877,0.01186433,0.060983334,0.09714676,-0.019160636,-0.0344246,-0.012788146,-0.03399223,-0.037093572,0.03355313,0.012770498,0.050303146,-0.006564852,-0.032390125,-0.045169268,-0.052556526,0.010438929,0.02109203,-0.007221145,0.014975455,-0.089836225,-0.03252754,0.060150128,-0.06915303,0.059765432,-0.07720643,-0.08959517,-0.023543922,0.027970271,0.09205348,0.005776419,0.019944824,0.014822812,-0.011318027,-0.084483154,-0.07122474,0.08353379,-0.025321018,0.011367878,0.07426473,0.07916441,-0.024268769,0.055365168,-0.0021060728,0.11162013,0.026430152,0.035213802,-0.0068396707,-0.034043193,-0.034063574,-0.086291656,0.05442698,-0.08204352,0.013022761,0.021191254,-0.025464451,0.00949902,0.028368091,0.014857664,-0.015113581,-0.0071321176,0.038597587,0.020407813,0.058897745,0.008242662,-0.021731375,-0.011847333,-0.014115614,0.042815845,-0.008200763,-0.008030491,0.05150149,0.061496213,-0.07656013,-0.014705276,-0.03914616,0.0011431236,-0.0027934923,0.012552161,0.04359619,-0.0028393138,0.07243062,-0.1314969,2.9405786e-33,-0.0142407585,0.022415671,0.0073838443,-0.040527236,0.004855447,-0.027669244,-0.06155142,0.018124027,-0.031376548,-0.042957038,-0.046329647,-0.0926856,0.021738611,-0.004376723,0.012695113,0.0052763745,0.019428851,0.055551257,0.030296966,0.06559327,-0.0035965128,0.060189556,-0.057480946,0.020776475,0.059503656,0.10786126,-0.024846395,-0.0008466263,0.10213341,-0.04365895,0.031669613,-0.087232865,-0.05037997,-0.02377835,0.036186516,-0.009820532,-0.03445834,-0.037315812,0.032953538,0.07336258,-0.035561156,0.023189068,0.021360204,0.028604941,0.043228336,-0.04367296,-0.056252506,0.09435264,0.061802287,0.071147084,0.012570753,-0.02755783,0.068804935,-0.030146265,-0.07079727,0.0723702,-0.0006261482,0.05029478,0.05335041,0.023242002,-0.014974386,0.034147944,-0.04812705,-0.015959786,0.07643937,-0.021372322,-0.039401986,-0.046962135,0.020880843,0.07339537,-0.15901197,-0.009454993,-0.016640663,0.02861998,0.030983577,0.008543739,-0.06796837,-0.033520654,0.064018905,0.0063039428,-0.08868683,0.010444133,0.015787192,-0.06252884,-0.079689026,0.02211172,-0.02943075,-0.07935617,-0.01701667,0.02729637,-0.0035646474,-0.06581694,-0.08703756,0.009439005,0.017222876,-4.286583e-33,0.084698014,-0.0976309,0.046759278,-0.04340919,-0.052299455,0.12086451,-0.06028509,-0.03693019,-0.05489266,-0.0002599774,0.054497268,-0.036353026,-0.02034077,-0.057453617,0.0149339335,0.008007984,0.008612858,0.063814715,-0.04220623,0.048658535,0.02819323,0.1345695,0.038177405,0.007851383,0.020959273,-0.033123955,0.019188566,0.0558059,0.040306337,0.044509456,-0.015199532,-0.011080161,0.0062345727,-0.020639163,-0.061493125,0.079749376,-0.079993755,0.01045006,0.08366166,0.020578206,0.03435268,-0.0042884517,-0.0004696382,0.05474653,-0.031820808,0.053421278,-0.08882397,0.014497903,-0.013840681,-0.072904624,-0.023227938,0.055651713,0.011631769,0.00926627,-0.0039675976,-0.052444022,-0.003428444,-0.044311035,0.018136129,-0.056364354,-0.022181142,-0.019050501,0.03827359,0.033070233,0.0303661,-0.013341208,-0.041092582,0.06598428,0.12228588,-0.03260121,0.037219908,-0.03228023,-0.063196294,0.040254984,-0.046648555,-0.011030683,-0.06366884,-0.03012441,0.028861733,0.00069961126,0.007418458,0.004930036,0.009355122,-0.04969954,-0.053157307,-0.021185441,0.043695934,0.034558184,0.010112087,0.052804142,-0.0131803565,0.049876194,-0.022294912,0.038104907,-6.5065266e-05,-3.7154063e-08,0.013139603,-0.0381104,0.08277308,0.007181445,0.014955742,-0.025137644,-0.052796297,-0.024319537,0.007985427,0.0063517056,-0.02432065,-0.017459312,0.012011969,-0.031662595,0.006232857,0.04785235,-0.05775016,0.04147197,0.0016797534,0.025231719,-0.060599234,0.0148984585,-0.17307979,0.04140327,0.08771507,-0.06506237,0.0118479375,0.0008314731,-0.0035766028,0.043909576,0.007379129,-0.0038336539,0.005535546,-0.06770816,-0.017740773,0.0055118506,-0.077204816,-0.07149226,-0.008343981,0.003947285,0.09284346,-0.0045829527,-0.061142948,-0.0024822312,-0.04452635,0.06530604,0.04264331,-0.047180604,-0.02868781,-0.052275047,0.05210767,-0.008122961,-0.00048812054,0.00536339,-0.1105527,0.04001689,-0.021766748,-0.050229892,-0.04936321,-0.04820356,-0.0026103128,0.030731393,0.20755054,-0.03571012 +1.3.1.122,"Isolated from the plants Catharanthus roseus, Olea europaea (common olive), and several Nepeta species. The enzyme reduces 8-oxogeranial, generating an unstable product that is subsequently cyclized into several possible products, either non-enzymically or by dedicated cyclases. The products, known as iridoids, are involved in the biosynthesis of many indole alkaloids. cf. EC 1.3.1.123, 7-epi-iridoid synthase.",384,1.0,-0.029089203,0.034337524,-0.1161333,0.011881592,0.02364035,0.043504003,-0.05815813,0.024417788,0.090175815,-0.05149268,0.070968196,-0.077785835,-0.07460286,-0.07160595,-0.04653141,0.056948602,-0.04577944,0.096368186,-0.07377714,-0.06694637,0.071258895,0.033158764,0.00055708404,0.020898271,-0.010563246,-0.0049645933,-0.0082777105,-0.044760104,-0.036682315,-0.094009675,0.0137276435,-0.0037824605,0.012777753,-0.0041661705,0.034853112,0.06353252,-0.047481757,-0.027054101,0.03854315,0.061832834,0.010487789,-0.033033356,-0.029597998,-0.042494748,-0.013361043,-0.037537534,-0.02064934,0.039130647,0.036723793,-0.051141433,-0.056573655,-0.024034915,-0.0403156,0.019979062,-0.07606615,-0.07377834,0.0108018685,0.008143146,-0.024556318,0.067758374,0.08409217,0.020832125,0.014816582,0.028206894,-0.107668914,0.0049456665,0.020770565,-0.04186739,-0.009132753,-0.059831154,-0.010081185,-0.07423068,-0.036278874,0.00055061554,0.0014994453,0.10616655,0.033638813,-0.013359227,-0.04840724,-0.023307398,0.046863634,0.038659297,0.012767719,0.05062058,0.095721774,0.017236426,0.028824983,0.022505878,0.06423522,0.03512453,0.017262608,0.03213051,0.064817436,-0.032035064,-0.0036926898,0.094211094,0.04986869,-0.023405557,-0.0019077401,-0.006523835,-0.00978892,0.020537049,-0.04395046,-0.04908543,-0.11854213,0.019140396,-0.02696332,0.024983196,-0.03316873,-0.016306477,-0.01025939,-0.06460036,-0.037656933,0.007370719,-0.025124297,0.10263058,-0.0030449578,-0.04353474,-0.01709874,0.004898855,-0.022102136,0.0024250313,0.050120536,0.064841546,0.013996452,0.056374796,-0.10905847,2.8045198e-33,0.10098006,0.06771645,-0.06375545,-0.059931386,0.02022882,-0.016824493,-0.06940148,0.040646806,-0.05824262,-0.042434406,-0.083912194,0.030693058,0.026038364,-0.056767214,0.026347417,-0.012198428,0.044206366,0.0162492,0.065122925,-0.05105336,-0.027616857,-0.0069321324,-0.029642455,-0.003650152,-0.08202352,0.056991022,0.019760797,-0.03642418,0.02298406,-0.028411126,-0.028206982,-0.12859094,-0.024445023,0.016618116,-0.008502709,-0.0057013016,-0.076877855,0.009144214,0.00028251612,0.08853128,0.00080013374,0.1075568,0.066770494,-0.0036070764,0.10335348,-0.055471525,-0.069846235,0.091577455,0.0496109,0.029636104,-0.017001644,0.019807843,0.10829454,0.031360596,-0.07857471,-0.026741652,-0.02115096,0.032767422,0.025412718,0.021694927,-0.038674444,0.06282087,-0.0016642497,0.0035312336,-0.010660959,0.03250071,-0.04030619,-0.034991298,-0.05350638,0.027199466,-0.011636983,-0.051704828,0.06615947,-0.013183274,0.07038539,-0.03590159,-0.010709405,0.012376305,0.005227983,0.038304653,-0.023876697,0.02106517,-0.04458356,0.015465009,-0.00019206411,-0.022267807,-0.060077034,0.06042313,-0.011900912,0.06121232,0.053761918,-0.042884167,-0.062383562,0.017428974,0.02849366,-1.5563795e-33,0.03252844,-0.06863287,0.016946124,-0.11115477,0.007482146,0.07045894,-0.053032156,0.018584615,-0.01833867,0.031729806,0.00392654,-0.039754506,0.09414531,-0.034348432,-0.05370796,-0.08910869,0.060704928,0.14446294,0.029023819,9.879428e-06,-0.03019512,0.05548549,0.004882986,-0.01030147,0.06238357,-0.015009902,-0.011101053,0.06470955,-0.02680765,-0.014580726,0.02178006,-0.02609073,-0.083051406,0.0031224769,0.0055086515,0.09576879,-0.071080305,-0.03361063,0.057516407,0.07158319,-0.06377522,0.0027432495,-0.012207038,0.060830597,0.08955817,0.077973954,-0.052934866,0.067299016,-0.031714506,0.008948676,0.042640306,0.03236305,-0.022646038,-0.02444397,0.05361662,0.0018572721,0.024820073,0.04015139,-0.017708149,-0.037729867,0.034458056,-0.06538097,0.02570593,0.0063295444,-0.017339433,0.102176376,0.005237028,0.07966052,-0.023881659,0.02884357,0.12410602,0.014308181,-0.050795186,0.03589716,0.01974334,-0.054152284,0.010279908,-0.096970804,0.008362876,-0.08494527,-0.01042858,-0.005438998,0.035132203,-0.076978914,0.00010035594,-0.03154402,0.054701637,0.07691838,0.041943498,0.095089085,0.026489351,-0.009954352,-0.041379426,0.11798395,0.119482905,-3.7414548e-08,0.06351609,-0.07531587,0.05971272,0.0031288564,0.016273439,-0.023160346,0.020781476,0.014191778,-0.0069506695,-0.059977967,-0.008970819,0.038794458,0.022501364,0.041905694,0.07639087,0.0020169471,0.0843319,0.08059419,-0.0052428087,0.020548353,0.021540571,0.014164406,-0.033925727,-0.046620857,-0.010249744,-0.12353723,0.06147367,-0.06497527,-0.025667245,-0.067763194,0.05647811,0.013123414,0.02538956,-0.036407184,-0.026051603,-0.008436985,-0.02879471,-0.0024793008,-0.040163733,-0.073773764,-0.09644711,-0.062475797,-0.06411066,0.008564962,-0.0060518533,-0.011153786,0.012816278,-0.054076374,0.037282184,-0.011396747,-0.010745915,-0.05364939,0.10940358,-0.12010476,-0.08449468,-0.05043231,0.047276266,-0.056862805,0.039896183,-0.055763956,0.0121217165,0.010918656,0.16259131,0.027813187 +1.3.1.123,"The enzyme, characterized from the plant Antirrhinum majus (snapdragon), is involved in biosynthesis of 7-epi-iridoids such as antirrhinoside. The enzyme catalyses the stereospecific reduction of 8-oxogeranial, forming an unstable product that in the absence of additional cylases undergoes spontaneous cyclization to (-)-cis,trans-nepetalactol. cf. EC 1.3.1.122, (S)-8-oxocitronellyl enol synthase.",384,1.0,-0.06633106,0.03151594,-0.075848445,0.014440803,0.021641856,0.0075355624,-0.115675636,0.061109267,0.07125007,-0.014689776,0.06996182,-0.043750953,-0.02995724,-0.022276048,-0.049005013,0.019870538,-0.08022235,0.07972517,-0.00856312,-0.07554948,0.066822425,-0.035401985,-0.0010633004,0.049231272,0.038428076,-0.06487814,-0.03091645,0.023826212,-0.034767278,-0.052889116,0.018829709,0.032306023,0.052406665,-0.080699384,0.054370884,0.029929232,-0.049529687,0.02754193,0.12108604,0.014254588,0.016886916,-0.024480268,-0.05516353,-0.058795184,-0.03408575,-0.065082826,-0.013339883,0.02949408,0.003361311,-0.0071538305,-0.06137499,-0.010860318,-0.08355617,0.043386105,-0.023151755,-0.0040896884,0.0066100825,-0.009347029,0.02253899,0.050078135,0.069340825,0.04488277,0.0051920153,0.026786698,-0.08285024,-0.008090892,-0.054678395,-0.039918236,0.040421404,0.038651098,-0.016953524,-0.061861876,0.011780868,0.01017784,-0.002740938,-0.0112986,-0.040470522,-0.018720916,-0.035723377,0.026976265,0.06404187,0.049629305,0.052252613,0.012399554,0.08539083,0.028283777,0.035135683,-0.010221802,0.033936758,-0.000667623,0.053609107,-0.0067172633,0.042073954,-0.006503779,0.057897635,0.07902506,0.015104065,-0.056153677,-0.049618818,-0.02051035,0.06961361,-0.007953386,-0.04728206,-0.09158888,-0.0354255,0.04620062,-0.010431544,0.021051824,-0.019971125,-0.024332253,-0.025050743,-0.061533824,-0.011040472,0.009767175,-0.0903796,0.11495295,-0.0003638747,0.018509675,-0.055586908,-0.020513142,0.02707548,0.026835464,0.004104714,0.10365264,-0.017879194,0.044727802,-0.08349905,2.4536373e-33,0.0315324,0.0040739216,-0.01563959,-0.050229385,0.0035102288,-0.022188643,-0.039463483,-0.01933371,-0.021146473,-0.0119998,-0.09697651,-0.03799737,-0.022005603,-0.018969845,-0.027587654,-0.03988401,-0.06028352,0.018450541,0.04346156,-0.0005144186,-0.00370594,-0.013521306,-0.0550985,-0.025588233,-0.06283563,0.08867835,-0.02676206,-0.029066259,0.08550073,-0.018473413,0.0096764825,-0.07079804,-0.07614518,0.030449854,0.038784977,-0.07752898,-0.023780478,-0.04762063,-0.011662093,0.07171219,-0.01615601,0.05759656,-0.01936801,-0.064141124,0.09142359,-0.085544854,-0.03419082,0.10532295,0.07756662,0.058124322,0.028177338,0.03113073,0.040406633,0.01862806,-0.06454689,-0.059504513,0.037710927,0.05292997,0.023086073,0.008165226,-0.035626892,-0.018439421,0.03546743,-0.06871219,-0.019421758,0.03132367,-0.046907354,-0.046126008,-0.028949985,0.024563223,-0.0535988,-0.03349475,-0.015490527,0.015780171,0.07079076,-0.050692003,-0.07889333,0.06234083,0.03698975,0.057927653,-1.2651524e-05,0.051981695,-0.032149263,-0.014814537,0.02795501,-0.037536506,-0.051420808,0.0025809344,0.013158256,0.08241136,0.081673644,-0.057156116,-0.103269,0.12767337,0.032749373,-2.5978666e-33,0.06017198,-0.054538086,0.05095755,-0.06332648,-0.07617591,0.061380353,-0.042571705,-0.02181098,0.034769043,0.033228137,0.017515114,0.027784364,0.036604635,-0.044197228,0.015947022,-0.03203005,0.11140695,0.11725129,-0.025321554,-0.038741488,-0.009963722,0.041738495,-0.021236122,0.0008633811,0.057536885,0.038023666,0.047660865,-0.0012554788,0.025443967,0.044397015,0.018206501,-0.05236884,-0.11091448,0.02853112,0.0023181287,0.061819315,-0.073802374,-0.004942019,0.0012181232,0.021713655,-0.030026574,-0.029256271,0.049610183,0.069253504,0.06270206,0.02388304,-0.078949735,0.0871143,-0.031034376,0.0008237911,0.030894646,0.043452915,0.022980629,-0.015605075,0.06689199,-0.045143217,-0.029861094,0.029203968,-0.012172248,-0.04909733,0.0035449453,-0.043789417,-0.01377291,-0.041278765,0.009985307,0.12787239,0.006076812,0.08066267,0.008013222,-0.014220473,0.123426266,0.03337165,-0.052675914,-0.009029286,0.0102237305,-0.029134177,0.025644837,-0.09604528,0.020974755,-0.07210945,-0.064104214,0.014943467,1.8896895e-05,-0.084297165,-0.07145056,-0.053388268,0.0055694194,0.13435379,0.078491114,0.08308843,0.08255664,-0.024451297,-0.037480358,0.06786034,0.18316036,-4.100724e-08,0.015622781,-0.08526298,0.02951054,-0.051345617,-0.009056281,-0.03356837,0.0033229569,0.021521684,0.014160142,-0.054638986,0.05861493,0.028430328,0.050418388,0.05037634,0.036883205,0.004791388,0.07640086,0.1191779,0.016541105,0.022294657,-0.040799495,-0.03958551,-0.09438607,-0.023538098,-0.027287997,-0.118299715,0.061041392,-0.04892737,-0.049657885,-0.023039931,0.06458419,-0.0029313334,-0.009523737,0.00425531,-0.052029967,0.031389054,-0.026436325,-0.017233942,-0.012351185,-0.095226765,-0.030935818,-0.019784993,-0.023947699,-0.017444579,-0.022722265,0.012044533,0.014989488,-0.008102467,0.03441483,0.034149878,-0.013287747,-0.054001868,0.0727815,-0.09495931,-0.10545055,0.013126204,0.036907487,-0.03976771,0.014400522,-0.054437373,-0.021662991,0.012283192,0.17066179,-0.010494146 +1.3.8.15,"The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. Unlike EC 1.3.1.31, 2-enoate reductase, this enzyme has minimal activity with crotonate.",384,0.99999994,-0.022084745,-0.063653134,-0.087388776,-0.01985781,0.09073801,0.066716254,-0.022744829,0.008048365,0.016997455,0.020666486,0.00656615,-0.117555246,-0.04764627,0.071212105,-0.03291002,0.032522846,-0.03457703,-0.09615469,0.02480018,-0.068800345,0.06631764,0.034117274,-0.035061304,0.055751007,0.058257695,-0.040150408,0.01938842,0.0038039617,-0.072810955,-0.019744892,-0.022328341,-0.0677251,0.105021,-0.02666108,0.08915526,0.12403402,-0.017271055,-0.053975068,0.072015695,0.044564217,-0.018890304,0.009407379,-0.010377072,-0.028827785,-0.007853712,0.006388729,0.046208173,0.0012502485,-0.002495766,-0.047313042,-0.0694301,-0.056014374,-0.015789261,0.017379941,0.055483457,0.074975386,-0.0023552626,-0.004257469,-0.03447133,0.036022797,0.03878728,-0.006538487,0.010234934,-0.025965836,-0.011582554,-0.0811405,0.028006548,-0.06802343,0.026881807,-0.050587792,-0.03225684,-0.0960373,-0.039862297,0.023791656,0.0045436593,-0.06612299,0.00523674,-0.041585077,-0.054636177,-0.042793434,0.0055003064,-0.026665913,-0.0133541385,0.036427863,0.03754616,-0.02933346,0.013884552,0.0067532314,0.07098889,0.006150874,0.020792622,-0.019885207,-0.00868949,-0.0745511,-0.025809087,-0.010709312,-0.017028358,-0.004414876,0.022354351,-0.024493063,0.0012154604,0.084433004,-0.0301032,-0.062450584,-0.0128036495,0.022935532,0.07406114,0.12980789,0.014138463,-0.016868196,0.019023556,0.012538786,0.07972486,0.015186097,0.00037595138,0.06456483,0.009818296,-0.05832195,-0.04785651,0.032622702,0.030952439,-0.054081038,0.064657494,0.06290182,-0.029707382,0.031304393,-0.08074792,2.1408983e-33,0.093710646,-0.008650159,-0.025699764,-0.030454874,0.019947778,0.05902697,-0.07266217,0.04863509,0.042158574,-0.10913744,-0.063763626,-0.078097805,0.056118056,0.021978632,-0.026268188,-0.004177632,-0.09624805,-0.006956015,0.002131827,0.068572916,-0.032362033,0.0044450425,-0.02376131,0.018895725,-0.0064030346,0.003714561,0.03109398,-0.010506419,0.0052869236,-0.02586057,0.03566024,-0.041804586,-0.084318414,0.0146411015,0.04799202,0.0038745378,-0.040048007,0.034615267,-0.048781123,0.07244199,0.015178672,0.14371687,0.023416441,-0.030048983,0.017227223,-0.016420575,-0.052043103,0.11051458,0.07597483,0.04958395,0.063779816,-0.0066185133,0.07364173,-0.04280552,-0.02676912,0.029223517,-0.00374377,0.020864904,0.05474317,0.021510921,-0.009160737,0.01846319,-0.005920337,0.028758101,0.011528689,0.019755084,-0.035614528,-0.053308107,0.044903245,0.046334524,-0.11386845,-0.049852807,0.06905706,-0.005634804,0.014981698,-0.10269628,-0.11554802,-0.060591813,-0.008507151,-0.043839723,0.017985886,-0.09167139,0.030349398,-0.00861719,-0.07916652,-0.035557453,-0.012745952,-0.045447916,0.031892158,0.016949348,0.048597474,-0.052290484,-0.028486695,0.040487204,0.013131245,-1.8768237e-33,0.06460108,-0.088040054,0.040366676,-0.066092916,-0.055642195,0.09960044,0.036657963,-0.019376377,0.0088905655,-0.016779086,0.13871919,0.014902709,-0.002497329,-0.020811286,0.051884506,0.003257598,-0.015579415,0.093020625,0.004795613,-0.0016598473,-0.0155957015,0.020421684,0.0033236912,-0.04169738,0.09793499,0.09917659,-0.07023234,0.10834535,0.043139435,-0.05275102,0.008619053,-0.016208457,-0.046906013,-0.06818065,-0.01729596,0.07801115,-0.081165165,-0.010020058,0.0018619975,0.029955246,0.076759934,0.056224585,0.033197798,0.06275574,-0.032146417,0.06706199,-0.072879285,0.030552473,-0.04432647,-0.06570464,0.0046108332,-0.054922525,-0.039417457,-0.041662466,0.044003498,0.03731529,-0.035196356,0.07404258,-0.04476883,0.014082776,-0.055627998,-0.0017415881,0.05980799,0.050288655,0.015826823,-0.014218379,-0.015448447,0.099264145,0.041426856,0.049400046,0.079129934,-0.009497147,0.063558124,0.079413936,-0.094385535,-0.047028642,-0.09868852,-0.030524222,-0.0059717544,-0.016240383,0.029700339,-0.008779531,-0.007681028,-0.018810326,-0.03447452,-0.08344021,0.020064207,0.048222728,0.013419283,0.033053353,-0.0086770635,-0.03714129,-0.007116395,0.027722469,0.14155507,-3.4236002e-08,0.061417896,-0.12960647,0.024419175,0.013719245,0.027023477,-0.021593368,0.01694159,0.031835936,0.012981957,-0.04492035,0.027000844,0.032337688,0.027783046,-0.0066912114,-0.01888251,0.06331829,-0.017753309,0.035035323,-0.032141738,0.04434656,-0.07634717,-0.039316703,-0.14795893,0.024076907,-0.007216645,-0.033848774,-0.010460751,0.12566952,0.01643898,-0.08181013,0.011720684,0.009810527,0.08290311,-0.002309122,-0.08647911,0.015512333,-0.088722646,-0.010230554,-0.08119288,-0.044789992,0.013727314,-0.04389554,-0.070572816,-0.012244244,0.012834947,0.016472444,0.009833981,0.008981404,-0.03566675,0.00025747978,0.023600837,-0.0073567145,0.054354146,0.0028207721,-0.10346588,0.041575763,-0.03674567,-0.03577471,0.022926427,-0.045307368,0.02183657,0.068402596,0.15108547,-0.041121576 +1.8.4.15,"DsbA is a periplasmic thiol:disulfide oxidoreductase found in Gram-negative bacteria that promotes protein disulfide bond formation. DsbA contains a redox active disulfide bond that is catalytically transferred via disulfide exchange to a diverse range of newly translocated protein substrates. The protein is restored to the oxidized state by EC 1.8.5.9, protein dithiol:quinone oxidoreductase DsbB.",384,0.99999994,-0.13341378,-0.027634498,-0.045923043,-0.010200497,-0.0021195607,-0.057342794,0.002271895,0.123606145,0.0748713,-0.025989804,-0.04777331,0.017234236,-0.061355222,-0.014367796,-0.013427574,0.05994665,0.035213575,0.051717754,-0.032467168,-0.002211991,0.047233913,-0.009235805,-0.05065677,-0.027714144,0.03826769,0.047174912,0.06446284,0.04501416,-0.037651286,-0.0683897,0.0021125707,-0.03843132,0.04603205,0.02870849,0.009215248,0.050331116,-0.014238384,-0.02424266,0.04474539,-0.085313216,0.055312242,0.032318506,0.0052420367,0.0016586683,-0.051800754,-0.020629508,-0.036095183,0.08763151,0.0003985928,-0.044966813,-0.035513494,-0.04445039,-0.04652468,0.15809596,0.012777411,0.072324835,-0.0041205524,-0.0013838713,-0.057898875,-0.035420675,0.0102295615,-0.0074090986,0.042658273,-0.014410731,0.06369636,-0.015285268,-0.006814935,0.0025380575,0.014501146,-0.05255352,-0.02002273,0.010820891,0.046877764,0.058028527,-0.027490482,0.030598355,-0.03500644,0.023844482,0.13663034,-0.04824899,0.048201233,0.014426627,0.054144178,0.167598,0.052960742,-0.03559315,-0.0413553,-0.00529206,-0.018979851,-0.013242314,-0.011111006,0.02635453,-0.04836656,-0.034741547,-0.10327201,7.2033254e-05,-0.012202092,0.05306606,0.00027000523,-0.028806198,0.0099090645,0.082038574,0.00014784012,-0.06873796,-0.06946133,-0.044340137,-0.0011716483,0.03460366,0.004672797,-0.051132277,0.0023165238,0.053058792,0.022727728,0.031622265,-0.079309165,-0.023891592,0.0042704106,0.024504112,-0.08228543,-0.06933166,-0.06281931,0.018952923,0.019198434,0.0055329967,-0.023662109,-0.046128213,-0.06747461,5.3280494e-33,0.08285782,-0.01760107,-0.010760072,0.03181695,-0.010633025,-0.034466226,-0.051631987,0.036941007,-0.07125774,0.011324725,-0.0721253,-0.07078547,0.012025602,-0.017267985,-0.008248448,-0.03430115,-0.022256054,0.018540014,0.04531234,-0.03581978,0.06167633,0.08412094,7.728664e-05,-0.008402253,0.0662046,0.026860835,-0.010697742,-0.007999748,0.044405077,0.0586086,-0.07617146,-0.09955748,-0.01659388,-0.022026705,0.012301843,-0.0110073015,-0.11322089,-0.030920098,-0.043893952,-0.013674002,0.0036337746,-0.020475775,-0.03740172,-0.050785705,0.019002488,0.0045805355,0.042351972,0.03273047,-0.026681926,0.060282104,0.016849369,-0.10208124,0.08843659,-0.0584851,-0.030500384,-0.038659714,-0.0339668,0.017627072,0.058691815,0.07943272,0.052075766,0.06005712,-0.13016635,0.021763118,0.016103895,0.04362088,-0.046520174,-0.02448415,-0.014722394,0.116467714,0.0074451347,-0.0039869505,0.026856503,0.009639352,-0.024714084,-0.03653951,-0.0031615803,-0.0056683673,0.08725115,-0.015712261,0.015243977,-0.065658934,-0.053288665,-0.039014414,-0.018027116,-0.009336445,0.036970433,-0.050897967,-0.06634804,0.010143028,0.055351708,-0.11031955,-0.07816784,0.015483101,0.005230172,-4.8660525e-33,0.03854115,-0.06363913,0.02348488,-0.020023873,0.0045614615,0.0303377,0.021950478,0.05461055,0.107007094,-0.022084821,0.05401536,0.0011239509,-0.008227531,-0.020457687,0.0028460864,-0.01062186,-0.07399616,-0.010491175,-0.08357384,-0.050649177,-0.022480026,0.09141641,0.08195406,0.022522075,0.0057711406,0.030458404,0.03408807,0.15708417,0.012679313,0.0978233,0.041912284,0.06522361,-0.025894322,-0.04960934,-0.10482512,0.042867467,-0.036627825,-0.021519482,0.04928682,-0.029796895,-0.013835483,0.002927714,0.0046286266,0.070546865,0.009730951,0.08651364,-0.084535725,0.0620708,0.059511527,-0.06558054,0.03625254,-0.051533386,-0.01094335,0.037606604,0.007577646,0.025575541,-0.0720303,0.028078804,-0.061795294,-0.019796435,-0.0716306,-0.08540261,0.075948045,0.02682383,2.8967183e-05,0.06816048,0.040094867,0.07878324,-0.0040740175,0.055532448,0.09496497,0.07417681,-0.07351504,0.0042175623,0.005544858,-0.035247646,-0.11679428,0.049562316,0.02217125,0.05748474,-0.05160968,-0.0021262635,-0.0262818,0.0042194114,0.022688204,-0.047690127,-0.0128990775,0.12167388,-0.043080397,0.07158761,-0.07483305,0.013485051,-0.042601407,0.12918411,0.06927179,-3.653738e-08,-0.0046052868,-0.004770359,0.07308035,0.019023119,0.034899928,0.03730454,-9.222617e-06,0.059435293,0.06696742,0.039165396,-0.022432698,0.08027856,-0.053098053,-0.05404294,-0.01679316,0.029549591,-0.014887699,-0.05726128,-0.008318961,-0.083149984,0.0851472,-0.043692503,0.04280437,0.033081416,0.065404326,-0.01453196,0.002051529,-0.094314545,-0.029341739,-0.050867274,0.06010451,0.0649534,0.0092742015,0.02059097,-0.06194389,-0.005139964,-0.045804176,-0.033619516,0.014169501,-0.027259113,0.00075784593,0.015282627,-0.095847994,0.04070111,-0.014638143,0.013396008,0.0074009607,0.10647018,-0.07887171,-0.026533509,-0.0005630451,-0.008800544,-0.06559557,0.012464952,-0.12972616,0.023266137,-0.04244641,0.011590102,-0.019383403,-0.009515578,0.02262317,-0.016711129,0.10665876,-0.014667786 +1.8.4.16,"The DsbD protein is found in Gram-negative bacteria and transfers electrons from cytoplasmic thioredoxin to the periplasmic substrate proteins DsbC, DsbG and CcmG, reducing disulfide bonds in the target proteins to dithiols. NrdH redoxins, which are found in Gram-positive bacteria, catalyse a similar reaction.",384,0.99999994,-0.16504562,-0.007601887,-0.040103137,0.03376916,0.035675146,0.02617134,-0.034745988,0.08828989,0.028295085,-0.008626102,-0.024628503,0.0076772957,-0.045494333,0.026036343,0.017698925,0.035557624,-0.014130582,0.12140023,-0.01739817,-0.028357547,0.004655171,0.050931804,-0.01224276,-0.05461008,0.039398845,0.032267038,0.07598748,-0.015295247,0.029163266,-0.03538934,0.05517287,-0.036809612,0.022223365,-0.02357693,0.052573066,0.092745274,-0.01297691,-0.024902487,0.021379754,-0.12524608,0.015781602,0.06561345,0.04039634,-0.0069131707,-0.03838913,-0.001314062,-0.025990402,0.06967041,0.025525313,-0.092004254,-0.022640552,-0.023208879,-0.030923342,0.10538045,0.06126246,0.025420452,-0.030794103,-0.051046137,-0.029398793,-0.045058705,0.012737712,-0.001875495,0.03419474,-0.025011044,0.06797939,0.0007256934,-0.012609474,0.018304456,0.004545343,-0.030967355,-0.007674555,-0.023233889,-0.0015214838,0.042158965,0.001569683,0.031633824,-0.013123068,-0.063312,0.08296656,-0.062488127,0.049989752,0.040523138,0.110946156,0.19292581,0.022876179,-0.029541137,-0.0032098745,-0.023617279,-0.06104295,0.041165177,0.040322255,0.045687303,-0.04955341,-0.03861705,-0.11654428,-0.025536213,-0.008106007,0.0640678,0.017323416,-0.010988901,-0.004574831,0.10600563,-0.044706643,-0.04787111,-0.03587201,-0.015958354,-0.036514882,0.0606497,0.03912313,-0.05119708,0.060936023,0.066636875,0.031521734,-0.006122933,-0.029050175,0.014919974,0.015381385,-0.0040439502,-0.073384926,-0.11367602,-0.06918837,-0.0104672145,-0.012066344,0.025222613,-0.05779619,-0.00092395453,-0.09997048,3.4890987e-33,0.06417359,-0.037743796,-0.02986676,-0.023296302,-0.0035888322,-0.043779347,-0.062382415,0.0029025986,-0.03585409,-0.007939801,-0.08040241,-0.092645094,0.02304793,-0.01175012,0.00035980289,-0.068887435,-0.082114935,-0.0020190878,0.04139908,-0.027938005,0.014009146,0.05278156,0.008591341,-0.015646305,0.10214503,0.041221365,0.005766001,0.034897417,0.017358107,0.011490459,-0.02489737,-0.050125457,-0.078756675,0.041419633,0.024848193,0.014608846,-0.088143505,-0.012898795,-0.058036815,-0.019013368,-0.0031675464,0.016719218,-0.12760302,0.007933733,0.042634692,-0.01205065,-0.0052525396,0.029946467,-0.018902468,0.08455753,0.04642275,-0.045537345,0.062047347,-0.04632519,-0.035345364,-0.030311514,-0.023274558,0.011868619,0.071813144,0.10602775,0.039479267,0.032831192,-0.08091761,0.027601851,0.06236181,0.07115393,-0.009911591,-0.06583652,-0.024837743,0.053299695,-0.003730802,0.00052299764,0.044806287,-0.028078748,0.018790752,-0.046495326,-0.012193382,0.03518802,0.07020483,-0.041214615,0.012610807,-0.024435917,-0.04926041,-0.061555244,-0.00049349666,-0.01505427,-0.025557257,-0.0847556,-0.040362757,0.010591193,0.082193986,-0.114909835,-0.092740245,0.049368724,-0.038561426,-3.5419357e-33,0.037276436,-0.07189939,-0.003736458,-0.054340824,-0.07105776,0.020060606,0.010753365,0.012553103,0.097100504,-0.0045520104,0.0716678,0.019045075,-0.052804478,0.03371532,0.012388725,0.0026669847,-0.025859736,0.016911384,-0.04747624,-0.01438915,-0.015154788,0.114287354,0.016827902,0.061050083,0.041704524,0.026958805,0.006863894,0.09684477,0.024451343,0.021146573,0.056086645,0.08846,-0.06700951,-0.026520733,-0.0950972,0.06518414,-0.021308614,0.01375796,0.013594884,0.003078959,-0.012910888,0.065890715,-0.015942203,0.099051744,0.04437423,0.08526509,-0.12466145,0.04261833,0.042208854,-0.04867365,0.023689115,-0.04107433,0.041107085,0.01049603,-0.02818931,0.027189722,0.004166868,0.024588564,0.015850253,-0.00063811435,-0.034157462,-0.086291716,0.059616942,0.015471285,0.0067182784,0.02833097,0.035169568,0.08051834,0.017975353,-0.02979047,0.057884444,0.07863061,0.0252761,-0.023353068,-0.0342793,-0.01975378,-0.035136927,0.05715904,0.038203463,0.050014317,-0.0042959135,0.055483706,-0.002675327,-0.017341312,-0.006361866,-0.032664802,0.02143696,0.09649485,-0.034631263,0.029803686,-0.098120674,0.013313589,-0.007983998,0.075722866,0.10585708,-3.3664264e-08,-0.004664084,-0.07163628,0.0516567,-0.055971693,0.04210366,0.05518451,-0.0104233995,0.075371675,0.016982336,-0.005667373,-0.02448456,0.12500809,-0.074564256,-0.08682834,-0.022975745,0.02483444,-0.06464888,-0.06234408,-0.018097015,-0.050197225,0.059478957,-0.012375926,-0.014350497,0.09004028,0.048437167,-0.04873379,0.057511754,-0.09755261,-0.0114696445,-0.04089458,0.017689897,0.04894707,0.0019213752,0.004629837,0.0001581703,-0.04358581,-0.046396185,-0.039304495,0.015165638,0.0025199796,-0.04812167,-0.0070569837,-0.06360991,-0.00872071,-0.04812256,0.04009981,-0.012627269,0.06985052,-0.088241786,0.00092708017,0.065346494,-0.06606747,-0.051364664,-0.040955964,-0.16971707,0.021379773,-0.030444777,-0.0076628383,-0.028484387,-0.018731877,-0.01576254,0.010912363,0.12177043,-0.0049886745 +1.8.5.9,"DsbB is a protein found in Gram-negative bacteria that functions within a pathway for protein disulfide bond formation. The enzyme catalyses the oxidation of the DsbA protein by generating disulfide bonds de novo via the reduction of membrane quinones. cf. EC 1.8.4.15, protein dithiol oxidoreductase (disulfide-forming).",384,1.0,-0.1327131,-0.029878832,-0.045536313,-0.0010712777,-0.020453522,-0.061542444,0.0064097974,0.12475623,0.044316996,-0.06439896,-0.04618192,-0.013089928,-0.054208912,0.011038462,-0.025812099,0.03822902,0.022463512,0.061614044,-0.036129322,0.005106123,0.034500618,0.022290822,-0.05963396,-0.030023986,0.043233708,0.04817278,0.058709383,0.017582668,0.006347828,-0.049043916,0.060142193,-0.012862183,0.07739479,0.020015527,0.032584667,0.046410806,0.006703553,0.014621121,0.04050727,-0.051840574,0.004587238,0.039263543,0.04460234,0.03661197,-0.02486661,0.018195705,-0.04060772,0.07400985,0.009341181,-0.060368,-0.039772168,-0.0048806863,-0.05738592,0.14649966,0.056701746,0.0654227,-0.0066686044,-0.009673112,-0.059587162,-0.057707395,-0.015188873,0.01026625,0.021870049,-0.025608,0.06933185,0.016524551,-0.011829638,-0.013560368,0.04408401,-0.028050687,-0.037259653,-0.003862968,-0.008959927,0.025243476,-0.023423903,0.046690144,-0.028228682,0.03687447,0.14875908,-0.08027013,0.06568151,-0.013215045,0.088596486,0.16917236,0.031664126,-0.026773095,-0.028814271,-0.06336333,0.014133231,0.03257617,-0.016109996,0.027466746,-0.030054983,-0.017773695,-0.094794646,0.0032461442,0.007650932,0.085968494,-0.008909162,0.01957817,-0.008952918,0.021686295,-0.02619646,-0.042007223,-0.043261252,-0.07278926,0.010518304,0.03553896,0.000983045,-0.095590964,-0.008652002,0.06638712,0.027578304,-0.0012816432,-0.043130174,-0.042997815,0.061885785,0.03730561,-0.048020445,-0.08006241,-0.062724985,0.07176899,-0.0070656165,0.011442431,-0.04265385,-0.017599147,-0.08305748,2.5910606e-33,0.10775976,-0.030354287,-0.0035791576,0.009384677,-0.046626598,-0.040156506,-0.055290874,0.023745382,-0.055185445,0.025082616,-0.07547842,-0.07715206,0.02393806,0.009580907,0.024575593,-0.023197565,-0.019282583,-0.03574368,0.05144763,-0.019690534,0.018464172,0.059887722,0.024480315,0.005095766,0.06885681,0.008465104,-0.00032157815,-0.036827527,0.020773368,0.056707148,-0.0778732,-0.089999616,-0.044393215,0.011467143,0.021752592,-0.0044739814,-0.09513415,-0.02088383,-0.04038984,-0.0022505273,-0.018399123,-0.017681716,-0.08615484,-0.03693875,0.031691886,0.047897317,0.07223589,0.050888814,-0.024408078,0.061232146,0.021089077,-0.059993826,0.07710927,-0.017620001,-0.029136721,-0.02235539,-0.023280863,0.007190506,0.03466792,0.09865799,0.019689351,0.070167415,-0.12791017,0.022878136,-0.0009423362,0.035995062,-0.041918207,-0.031111797,-0.019633163,0.06931821,-0.011449515,-0.008427658,0.022847878,-0.014480621,-0.023304183,-0.016462505,-0.00015851662,-0.010800734,0.06375891,0.002908045,-0.0019411844,-0.040588975,-0.010617341,-0.066813335,-0.070992805,-0.0065748296,0.023341557,-0.06222764,-0.061220884,0.01737963,0.010867355,-0.098680146,-0.03850034,0.032570135,0.0075130844,-2.9426991e-33,0.012617716,-0.088599704,0.0074916887,0.012339341,-0.030562177,0.037884243,0.016098281,0.005784569,0.13856696,-0.022707857,0.026850045,0.020562464,0.00011914252,-0.02007847,0.014515309,-0.0034733987,-0.11016097,0.015778363,-0.06439564,-0.023752073,-0.0060410965,0.12842126,0.025490964,0.02021438,0.004990461,0.021800699,0.04007523,0.17148918,0.0043905936,0.06782619,0.028185077,0.06909525,0.0046000397,-0.032448456,-0.12045221,0.033613782,-0.0067179087,-0.0032738685,0.019474423,-0.04639099,-0.040296637,0.032618288,-0.0077522406,0.05962122,0.02287838,0.10293104,-0.05090698,0.06569537,0.04843929,-0.030700339,0.03269356,-0.05877397,-0.0020554888,0.045223195,-0.03515946,0.02528518,-0.0549711,0.050862875,-0.017459232,0.0050635934,-0.025102958,-0.091840856,0.052787438,0.020838728,0.0065639657,0.038575865,0.057646643,0.04838626,0.01778419,-0.00011287391,0.08403386,0.0652121,-0.0336375,0.0062720305,-0.0025019045,-0.018635157,-0.1287246,0.02749601,0.0068699406,0.04988463,-0.06550325,0.015877796,-0.0026406383,0.010594516,0.020838495,-0.05214869,-0.0041607316,0.11969153,-0.052880388,0.042421594,-0.103875116,-0.00807154,-0.07190973,0.14613365,0.09260887,-3.5436656e-08,0.03662602,-0.0306131,0.061404325,5.1079725e-05,0.015636174,0.05758304,0.026889749,0.05579236,0.045380794,0.025659708,-0.01736362,0.09202061,-0.09016687,-0.044020727,-0.022645436,0.00755344,-0.02573218,-0.045928866,-0.03636987,-0.09378751,0.08675773,-0.059161346,0.048545945,0.03682433,0.028115,-0.08818844,0.038966417,-0.06196284,-0.014287306,-0.056501605,0.033991482,0.06695743,0.018814964,-0.016166262,-0.06218453,-0.015668578,-0.046973642,-0.063151024,0.078533664,0.015596056,-0.032135822,0.020583462,-0.08106037,0.019650642,-0.003142414,0.014544153,0.0015603446,0.0961061,-0.067022145,-0.003793877,0.04948341,0.043565314,-0.08784673,0.04773997,-0.11397003,0.038668994,-0.06531865,-0.02682242,-0.020299328,-0.024786552,-0.046175297,-0.02443939,0.08267853,-0.07752748 +1.10.3.17,"This membrane-bound, di-heme containing enzyme, identified in the bacterium Escherichia coli, is responsible for the detoxification of superoxide in the periplasm. In vivo the reaction proceeds in the opposite direction of that shown and produces oxygen. Superoxide production was only observed when the enzyme was incubated in vitro with an excess of ubiquinol.",384,0.99999994,-0.10302068,-0.02769908,-0.067674115,0.07671085,0.03453902,-0.00766742,-0.022953033,0.119261116,0.04462059,-0.015304622,0.028770212,0.037639998,-0.06928531,0.041457023,-0.099211074,0.041259505,-0.04476771,-0.021734178,-0.086264685,-0.025544345,0.09549458,0.012406707,-0.062455818,-0.013417247,0.04303582,0.0006087279,0.046844833,-0.019874249,-0.0013814259,-0.031191941,-0.007908497,-0.06268446,0.10841543,-0.07627051,0.045732785,0.057026025,-0.011042667,-0.08326727,0.016072258,-0.0583606,0.0047442447,-0.0046442,-0.109892905,0.01485231,0.029438954,0.038855236,0.031351358,0.028380929,0.0248568,-0.004218313,0.000991572,-0.054700766,-0.063462265,0.058122043,0.029499495,0.016524317,-0.022263916,-0.078597255,-0.0062039453,-0.00465728,-0.019430788,-0.0029821952,0.04439999,0.032208156,-0.013019783,-0.045418695,0.041924194,-0.025416264,-0.08132861,-0.019524911,-0.0017531619,-0.07237787,0.00871203,-0.02959773,-0.030481225,0.014693965,0.0017063833,-0.07506055,-0.00068001245,0.034387715,0.0903401,-0.041945033,0.023159591,0.10925293,0.027240612,0.025845787,0.032168955,-0.09092278,0.011113958,0.030768067,-0.07384356,-0.00587895,-0.06709779,-0.020439707,-0.06862408,0.020991875,0.09300005,0.08508147,-0.0029300093,-0.030543355,-0.012746664,0.043760963,-0.04291219,-0.078027554,0.013068366,0.015592026,0.008617818,0.07439793,0.04849369,0.028060848,0.06564443,-0.030256407,0.026991926,0.0018007793,0.0076868325,0.013349538,0.060322065,-0.006829275,-0.07756658,0.00758228,-0.059246775,0.036404684,0.0022716217,0.0033425468,-0.030193467,0.008276115,-0.009086967,1.2234665e-33,0.04314895,-0.016660271,-0.09663161,0.010529675,-0.012918329,-0.032842774,-0.093417495,-0.03607819,0.022287652,0.024689386,-0.03465261,-0.08740739,0.028176095,-0.0435714,-0.031040616,0.020300318,-0.011965616,-0.010248836,0.011448217,0.020964758,0.046982326,-0.014002425,-0.024843946,-0.058700897,0.029256457,-0.0070797135,-0.05075554,-0.038677692,0.048745815,-0.012766289,0.015618932,-0.074266315,-0.080798835,-0.04197361,0.004824862,-0.023736024,-0.059357192,0.008938628,-0.040758595,0.04076787,0.0071840426,0.08669737,-0.06717965,-0.056122307,0.10646791,-0.08289773,-0.03680252,0.18064083,0.050432444,0.024182295,-0.014166616,0.004236796,0.095651925,-0.09355924,-0.02808378,0.010286841,0.051377203,0.049307212,0.07588114,0.046348613,-0.034680147,0.109671295,-0.08668055,0.091568455,0.038370095,0.043499094,-0.08221713,0.0082829585,0.028984968,0.04310502,-0.09126601,-0.0032949718,0.033577554,0.014299689,-0.06088816,-0.051112294,-0.043335468,0.0905805,0.094410874,-0.01591824,0.041551575,0.009922512,0.044598863,-0.048063494,0.04637265,0.014379944,-0.040051226,-0.024545588,-0.06564519,0.062795766,0.15965845,-0.0731081,-0.07358725,-0.073846415,0.009613136,-2.826456e-33,0.05021315,-0.06184257,0.0037505233,-0.086461306,0.023304028,0.11352621,-0.12753713,0.06205255,-0.012863575,-0.017342629,0.039790977,0.05966366,0.005953644,0.028263897,0.01621681,0.0009071055,-0.010235117,0.022656893,-0.032842495,-0.0376799,0.0124648195,0.024162173,0.05370301,0.05473925,0.016097281,-0.033659514,-0.027489929,0.04932001,0.047652848,0.04188412,0.0010318268,-0.0052917227,-0.043495953,-0.007556161,-0.040297516,0.031710874,-0.06718723,0.073865354,0.091751456,0.0036979176,0.0040084515,-0.051052723,-0.016536357,0.07598935,-0.0136668915,0.08805848,-0.12382137,-0.012608033,0.0064687342,-0.07726846,-0.010565681,-0.025302446,-0.05656106,0.0033758949,0.02052109,-0.0070661455,0.00396368,-0.029778574,0.008069485,-0.036064886,0.015312418,-0.073427446,0.090107106,-0.006536341,-0.010592832,0.05137962,-0.013820294,0.060918987,-0.040336855,-0.03982544,0.06682138,0.05805996,-0.07138766,-0.046903525,-0.00011942481,-0.015957955,-0.01969359,-0.038969573,0.014525933,0.04036228,-0.048095625,0.050012186,-0.047821205,-0.06426104,0.06715134,-0.058356088,-0.012837804,0.10798276,-0.0060106954,-0.018694181,-0.02772468,0.030108612,-0.06621686,-0.04100785,0.07467832,-3.8115516e-08,0.000387026,-0.031122642,0.08646015,-0.0017771441,0.009797259,0.023507845,0.021814438,0.05582348,0.05611854,0.027511455,-0.0060272934,0.14565621,-0.029604472,-0.009062429,0.041191168,0.04259536,-0.023618063,-0.021751046,0.005713571,-0.040515464,-0.009234681,-0.018794633,0.0010750119,0.021124005,0.05015312,-0.08010289,0.046823304,-0.040929973,-0.045032877,-0.08083678,0.010743099,0.048278503,-0.010246831,-0.0043349373,-0.061891302,-0.042455927,0.059732266,0.036718875,-0.040381655,0.033233795,0.004418917,0.0006467676,-0.086259805,0.018390577,-0.0051319967,0.081546016,0.057705123,0.019326814,-0.061785307,-0.053873364,0.05774787,-0.07368341,0.025876561,-0.02705272,-0.1107422,0.02987847,0.022864917,0.025415547,-0.0066981665,0.0023702085,-0.0030920224,0.02110404,0.16101623,2.4748142e-05 +1.14.11.70,"Requires iron(II). The enzyme, found in some cyanobacterial species, catalyses the last step in the biosynthesis of the toxins cylindrospermopsin and 7-epi-cylindrospermopsin. The ratio of the two products differs among different strains.",384,1.0,-0.122595906,0.014806764,-0.05643091,0.07497874,0.12865779,0.008102336,-0.04049261,0.040005002,-0.007884909,0.008182454,-0.019939413,-0.07107915,-0.06272649,0.049529515,-0.069759645,0.012994603,-0.04895939,0.049645387,-0.009216823,0.03167748,0.04416833,0.004218531,-0.04769687,0.043179367,-0.019624766,0.034772303,0.027746102,0.080098026,-0.020555148,-0.032520127,-0.096514545,-0.096835904,0.009174407,-0.090648405,0.07715108,0.033357088,0.011082954,-0.08239887,0.05044764,-0.021625223,0.0038353952,0.008628371,-0.033805907,-0.009439781,-0.04191817,-0.02511481,0.06601381,-0.0205315,0.02550633,-0.04632932,-0.062898114,0.03179738,-0.016737165,0.009316516,0.004474398,-0.03942465,-0.030935159,-0.057229377,-0.01161644,0.0029829103,0.041159242,-0.07536912,-0.06093722,0.027801953,0.0017140771,-0.043233324,0.004228812,-0.06882264,-0.013087303,-0.0027863272,-0.020815138,-0.05919876,-0.10632167,0.05994173,-0.03410218,0.10553885,0.0902522,-0.03544821,0.007698103,0.021165555,-0.009380359,0.025479138,0.05872396,0.072455466,0.07795887,-0.008055124,-0.00086702156,0.02794144,-0.01409553,0.13637215,0.0911599,0.041548833,0.02828194,-0.05949358,-0.025283962,0.08787679,0.0348518,0.034156915,0.051973023,0.011759145,-0.059948437,-0.0012576794,0.008462359,-0.045446463,0.03621095,-0.0023738032,-0.03834912,0.0808776,0.043847624,0.002191332,0.013480019,-0.03554718,0.021156326,-0.011303398,0.051813275,0.06717103,0.08269031,-0.02686946,-0.020510664,0.092400864,0.055642746,-0.060525145,0.031108752,0.071857646,-0.032666944,0.0033211017,-0.10567637,1.7734342e-33,0.04797251,-0.0016592103,0.0146555435,-0.012093979,0.00301783,0.0115735,-0.08402263,-0.0005282397,-0.005262019,-0.041703656,-0.12988968,-0.07355289,0.014689962,-0.048406307,-0.043085564,-0.020902324,-0.02661072,-0.033227805,0.05424183,-0.03730691,0.039454766,0.008368908,0.008476486,-0.016127374,0.03753482,0.10801872,-0.032390855,-0.007937365,-0.026451446,-0.011744155,0.03129437,-0.11849821,-0.10713196,-0.02376638,0.10280689,-0.042139743,0.059322186,-0.0817418,-0.009097763,0.023952913,0.0050195465,0.018208323,-0.034072246,0.047108654,0.094509736,-0.02216701,-0.099963225,0.07148118,0.023007985,0.031914398,0.06967102,-0.013619704,0.052455958,-0.0051280065,-0.04905428,-0.014145215,-0.033061303,-0.052761633,0.04831392,0.022988407,0.021904418,0.031047957,0.015293926,0.039995804,0.07148306,0.01611626,-0.04586998,0.0021953897,-0.0045724483,0.043467484,-0.07171473,-0.02219585,0.049474567,0.009335428,0.07211061,-0.066556856,-0.055597823,-0.011383682,0.057814058,0.021619882,-0.04962179,-0.047678445,-0.04705421,-0.023241207,-0.063957185,-0.0059328666,-0.03942341,-0.03286201,0.09363316,0.015248001,0.044748187,-0.05206563,-0.070160374,0.0344973,-0.03463735,-4.382186e-33,0.09168119,-0.08180208,0.08486099,-0.011666235,-0.07406262,0.030312415,-0.08055618,-0.073192105,0.02713995,0.00474314,0.060260437,-0.090404965,0.082650065,0.011320808,-0.00072951487,0.05920674,-0.021801027,0.08994053,-0.004753701,-0.038035482,-0.062134102,0.011945349,0.031891853,0.02212107,0.049247324,-0.0166706,-0.10093838,0.0022964438,0.044764727,0.08322549,-0.031315863,0.037958194,-0.02749479,-0.058891416,-0.02618759,0.0035647047,-0.022267342,0.008032558,0.082876116,0.032513376,0.07682413,-0.022608083,0.022110276,0.101346925,0.0109264,0.017117161,0.027469153,0.013595523,0.0074763442,-0.020711824,0.04846549,0.009048637,-0.09406285,0.023795534,-0.0007322085,0.020408263,0.06418476,0.04236717,0.015113122,0.06940431,0.014399996,-0.0720143,0.011263748,-0.0017093467,0.079040535,0.0733264,-0.018975675,0.092793085,0.013536284,-0.034417365,0.029060744,-0.034818795,0.080528736,-0.03841224,-0.006763699,0.055106893,-0.014454971,-0.047515575,-0.033593915,0.011865516,-0.01175235,-0.0021649033,0.007064607,-0.02389054,-0.08578897,-0.06076145,0.09509582,0.0526022,-0.07781887,-0.047490105,-0.0069882693,-0.0202259,0.044314492,0.06448338,0.0263498,-4.062591e-08,0.015747393,-0.02942529,0.032859463,-0.106346,0.022178696,0.06990599,-0.021557456,-0.053048704,0.03591871,-0.031726126,0.009545991,0.058365334,0.028898487,0.0023956934,0.089646176,0.017529938,-0.022210473,-0.014493682,0.0077764564,0.016311415,-0.097276434,-0.028654752,-0.08603066,-0.0008588808,-0.021881185,-0.062051177,-0.019618273,0.03245399,0.015367714,0.002978006,0.0041640876,0.01364348,-0.04751166,0.0024441604,-0.097214535,0.015792899,-0.053701475,-0.11717022,-0.025058692,-0.0702163,-0.09748023,-0.03186565,-0.08970957,9.447761e-05,-0.064646855,-0.0028236709,0.008493406,0.023711327,-0.073645726,-0.027075984,0.07196129,-0.07296022,0.042337995,-0.050531734,-0.028954819,0.04527355,0.085694835,0.0017643834,-0.05376452,-0.040698912,-0.015829008,-0.00076904864,0.16456519,-0.047166258 +1.14.11.71,"Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway.",384,1.0,-0.02343561,-0.025201345,-0.038010284,0.053638253,0.051797766,-0.0024937335,-0.025389127,-0.015275253,0.017139597,-0.03527181,-0.03775424,-0.046226945,0.0059435563,0.031202724,-0.0195764,0.02483795,-0.04818747,-0.0072700987,-0.026461992,0.07361779,0.0744673,0.074805565,-0.05593195,-0.056798816,-0.043460518,0.032601625,0.027394226,-0.0045663933,-0.060457677,0.04362109,-0.032263063,0.00979443,0.11965807,-0.061379522,0.063112095,0.118920155,0.0042441553,-0.11665817,0.00953582,0.028226756,-0.0338243,-0.010921676,0.0019566752,-0.02487848,-0.039123464,-0.04862688,0.0548978,-0.003961217,0.019581798,0.050617762,-0.10144109,-0.06767646,-0.016990798,0.025884073,0.013056513,0.02664035,0.030758318,-0.028257363,-0.06660913,-0.015913729,0.047858927,-0.031546913,-0.045063242,-0.0014681357,0.03039149,-0.02326474,0.10218987,-0.0463389,-0.006864024,-0.025720755,-0.036774445,-0.019217577,-0.111040674,0.016747136,-0.026440477,0.078697555,0.06344691,-0.082423106,0.07963046,-0.033819962,-0.06848728,-0.0044191736,0.033746064,0.03145553,0.037734296,0.04701386,0.033249486,-0.020492088,-0.013644698,0.10323012,-0.012125052,-0.023012111,0.053729523,-0.07779202,0.029274423,0.045600455,0.0013337794,0.030391479,0.033594403,-0.02069548,-0.04021495,0.03479933,-0.03297524,-0.09268749,-0.01228106,-0.008946998,-0.029166196,0.10890715,-0.0036920386,0.027548242,0.01225619,0.016621118,0.02151374,0.023590907,0.041180324,0.11815755,0.090254,-0.046467174,-0.09873802,0.053836033,0.019564636,-0.024944793,-0.0043028197,0.01980452,-0.06649601,-0.0031822866,-0.110916294,-2.2750064e-33,0.05903413,-0.00012427501,0.021539835,-0.05471043,0.013023818,0.0015042508,-0.128115,-0.06895234,-0.01002641,-0.058147132,-0.09788588,-0.0471689,0.013905824,-0.014780596,0.0053533614,0.016245725,0.029675676,0.0071620787,0.07292102,0.0059189643,0.065938994,0.05392146,0.07258073,-0.06452182,0.023778716,0.08161522,0.025351068,-0.052893713,-0.0030243383,-0.01010494,0.06352517,-0.17388828,-0.1127324,-0.044963773,0.12693578,-0.011264844,0.0022609087,-0.0067913984,-0.09065167,0.012942448,0.031662382,0.043979947,-0.030038744,0.0037732108,0.08983479,-0.10214604,-0.05023798,0.10597087,0.025118295,0.09282181,0.026308862,0.010414648,0.050466962,-0.0022690082,-0.062320318,-0.006056529,0.040941574,-0.032753065,-0.0037237173,0.028707838,-0.015170324,0.017379029,0.068581164,0.10612008,0.10271092,0.006649605,-0.07741642,0.034111653,0.0030074741,0.056008354,-0.04224417,-0.039098408,0.05149214,0.032803956,-0.03353507,-0.09063922,-0.0403169,-0.059498668,0.07171309,0.031054085,-0.02797549,-0.033900164,-0.0073055956,-0.048245724,-0.11122034,-0.00086981966,0.013837863,-0.02796232,0.035620987,-0.017565908,0.04911719,-0.021157375,-0.080921814,-0.019282656,-0.018773306,-6.701094e-34,0.053304918,-0.050590813,0.052970126,-0.054084256,-0.057158,0.036045004,-0.020064043,-0.062021088,-0.004376388,-0.0144623825,0.06641582,-0.00415713,0.011813128,-0.05258696,-0.0017122063,0.029685114,0.013188714,0.07467408,0.019506563,-0.016676892,0.016707378,0.07743312,0.04832103,0.051569168,0.012798144,-0.033586793,-0.07639078,0.017059172,-0.002436147,0.06307444,0.0153029105,0.050009243,-0.018055959,-0.13830242,-0.020363325,0.036398083,-0.028252564,0.014710612,0.055227388,0.040605392,0.036805596,-0.0016713969,0.06574554,0.10886675,-0.025871718,0.04957711,-0.043826867,0.018412903,-0.023260515,-0.0049839355,0.030610932,-0.07180973,-0.006656706,0.027436672,0.055047356,-0.011364674,0.0040553715,0.09158084,-0.06600179,0.019471096,-0.029615495,-0.03570431,0.03652252,-0.012678952,0.030972445,0.053384185,0.020643866,0.0618613,-0.008113718,-0.008688526,0.047961175,0.052871108,0.032911953,0.0077156136,-0.022999633,-0.039067287,-0.11186103,0.040443983,-0.048265934,-0.0054598954,0.0221945,0.035971783,-0.056928508,-0.043198526,0.0087498585,-0.09941174,0.038500264,0.025956593,-0.03446873,-0.025705868,-0.07224722,-0.05274485,-0.07123274,0.013118136,0.021557158,-2.6385345e-08,-0.025884386,-0.008558292,0.024779223,-0.07685447,-0.013881647,-0.0058470066,0.0025745663,-0.0045123403,0.038617376,-0.02822027,0.021755747,0.08422562,0.04093776,-0.0363818,0.037175737,-0.0039224853,0.004580855,0.025547724,-0.02313453,-0.032000992,-0.049803987,-0.01567929,-0.047975026,0.06292457,0.0038271446,-0.024057591,0.035414822,0.026044602,0.0064255395,-0.018839406,0.028429477,0.05064189,-0.06179067,-0.034192335,-0.15039109,-0.010329735,-0.010244871,-0.02963983,-0.04500578,0.07041923,-0.067360535,0.07938063,-0.11661805,0.0022159666,-0.0060929623,0.017023513,-0.0053555463,0.083089456,-0.023885624,-0.012613412,0.043677296,0.0005523952,0.01689415,-0.01569699,-0.08849707,0.11271663,0.04460634,-0.024473997,-0.017250406,0.016941177,0.048274763,-0.040544625,0.14872724,-0.11351128 +1.14.13.247,"The enzyme, characterized from the bacterium Sinorhizobium meliloti 1021, consists of three different types of subunits. The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyses the monooxygenation of a methyl group. The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde. The other subunits are involved in the transfer of electrons from NAD(P)H to the catalytic subunit.",384,0.9999999,-0.0762755,-0.03165108,-0.0708555,0.06446215,0.069396764,0.01584489,-0.06396625,0.007187184,0.030582989,-0.08363717,-0.035504933,-0.089207016,-0.043623798,0.008674124,-0.02717525,-0.032413572,-0.08400834,-0.0129772,0.027164157,-0.017641189,0.054267257,0.0032528837,-0.0028704442,-0.083244845,0.028255014,0.052517634,0.063776925,-0.0313305,-0.013245419,-0.08227931,0.06860085,0.0038211136,0.0020856236,-0.041805122,0.098450065,0.058612775,-0.027804684,-0.027096052,0.03318036,0.0016124095,0.013904631,0.0684638,0.02899851,-0.044009324,-0.02817219,-0.0028518774,0.015892018,0.030740662,0.036473878,-0.06641532,-0.041142825,-0.048100363,-0.04095057,0.06893108,0.06344206,-0.044210587,0.011965225,-0.03631325,-0.006485108,-0.02315046,0.07316592,-0.014134938,0.0046882695,-0.011784889,0.036305614,-0.06158332,0.027585324,-0.10527084,0.0751207,-0.047246028,-0.09211144,0.006962419,-0.04625471,-0.005536588,-0.036198452,0.036403112,0.006421031,-0.012728512,0.083594576,-0.038372934,-0.053563952,0.03412033,0.028080698,0.07020713,0.07286473,0.03092571,0.006233999,-0.0007425652,0.05340151,0.020737676,-0.03224412,0.072485134,-0.019422473,-0.001043974,-0.07665847,0.04808997,0.0769656,0.15838623,0.035312414,0.010383675,0.016953224,0.10359469,-0.021725522,-0.107444555,-0.08495343,-0.034699894,0.0005170361,0.1483231,0.049074717,-0.0020804333,0.012007273,-0.009035392,0.05442679,-0.03306978,0.011368383,0.02650719,0.056460083,-0.021136606,-0.068095945,0.02408119,0.032753084,-0.058274582,0.034637686,-0.0343849,-0.045934726,0.013110236,-0.13548489,2.7910846e-33,0.10542048,0.02346291,-0.07305519,0.028891116,0.016429896,0.01558979,-0.09346411,0.03483405,-0.04727651,0.010807055,-0.039073866,-0.060667843,-0.0108226435,0.025778368,-0.05006814,-0.031032996,-0.040134363,-0.016993832,-0.0057235537,-0.043493252,0.015485003,0.06273529,-0.028041603,0.021635363,0.010928639,0.07732658,0.004123688,0.01675193,-0.019639969,0.024453381,0.051656168,-0.08365402,-0.15889138,0.03768991,-0.009983635,-0.027378498,-0.041660596,0.010988743,-0.018927408,0.004096477,-0.031226119,0.06497238,0.020538567,-0.05380499,0.050346743,-0.07231509,-0.04618108,0.13902341,0.045748305,0.06543479,-0.032392457,-0.055460673,0.13759017,-0.053809464,-0.07160471,-0.0024204568,0.047771595,-0.028600128,-0.02246946,0.03533661,0.041951466,0.07188649,-0.025835855,0.048344206,-0.023652202,0.0057265772,-0.016250737,0.0191837,0.075550675,0.11589747,-0.022993645,0.03965497,0.023514338,0.05689332,-0.013603714,-0.06889968,-0.037549425,-0.020918423,0.06148307,0.06722119,-0.01043238,-0.017618008,-0.001508714,-0.028850265,-0.044926953,-0.009778828,-0.027119892,-0.050760575,-0.03804201,0.04867978,0.01019606,-0.053797722,-0.0427723,0.03278283,-0.054773074,-4.129851e-33,0.07553718,-0.007851925,-0.002738002,-0.16098371,-0.09972692,0.0408023,-0.036721453,0.016922155,-0.00969349,-0.0002962085,0.11724774,0.007829196,0.08494184,-0.008474669,0.04551111,-0.024327984,0.04967987,0.07170778,-0.012262648,-0.0062427674,0.037629403,0.056508653,-0.05560375,0.0038934436,0.033310425,-0.019248558,-0.025704162,0.05015861,0.0633534,0.047112294,0.019875383,0.012224629,-0.0487553,-0.022092368,2.8257742e-05,0.017121326,-0.0153223835,0.009447065,0.047550287,-0.0050701373,0.047914796,-0.006929927,-0.012344219,0.09979901,0.08037317,0.0034286552,-0.086790696,-0.05359526,-0.019715112,0.016351575,-0.00925711,-0.040563017,-0.009826802,0.037464257,-0.037515864,0.068210885,-0.010922214,0.03617958,-0.03177554,-0.035791285,-0.06471705,-0.071740635,0.030841641,0.034364726,0.00063499756,0.0337827,-0.048406098,0.009453255,0.02599552,-0.008422045,0.05998672,-0.016328346,-0.019579599,-0.0018784388,-0.08205357,-0.06272479,-0.0492533,0.03895471,-0.0042280024,-0.026320932,0.034229867,0.0033537121,0.024926614,-0.09562134,0.026050193,-0.11898297,0.037487492,0.0870445,-0.011212961,0.020261576,-0.024531148,0.008185153,-0.009904745,0.050612293,0.010669968,-4.6738396e-08,-0.053383168,-0.05864513,0.027007304,-0.014638255,-0.010114792,0.07821465,-0.04770817,-0.034408882,0.04554933,0.048741825,0.031420432,0.0991746,-0.018999305,0.013662159,0.017007902,0.039332315,-0.062022842,-0.0135576585,-0.019383213,0.013128362,-0.035364278,-0.0035369445,-0.033885002,0.046276562,-0.022210723,-0.070762575,0.0054303855,-0.042559847,-0.049423512,-0.05031446,-0.07326616,0.09311999,-0.027267417,-0.011080769,-0.11616347,0.008173178,-0.0093344115,-0.028259676,-0.004402349,0.024801942,0.07365173,-0.033401597,-0.11574915,0.021037973,0.04147351,-0.014159248,-0.04460614,-0.032918427,-0.08862425,0.029021464,0.08117528,0.013124636,0.005622781,-0.04816182,-0.12457868,0.049533147,-0.017404491,0.0035338746,0.020096544,0.0073834513,0.033775624,0.04145368,0.16012165,-0.07579086 +2.1.1.363,"The enzyme, characterized from the bacterium Serratia plymuthica, participates in biosynthesis of sodorifen.",384,1.0,-0.006400786,-0.024759091,-0.12567754,0.012652762,0.05241311,0.09277121,-0.09531823,0.06663405,0.067112386,-0.09948024,0.023167256,-0.06641135,-0.028171532,0.02960862,-0.023472067,0.026063822,-0.047338754,0.0109265195,0.048136983,0.015431256,0.14596686,0.009030951,0.01617194,0.085172206,0.025205638,-0.032251664,0.066988446,-0.030482985,-0.019923635,-0.04498601,0.010365345,-0.011503526,0.08634808,-0.04208976,0.027846498,0.08226116,0.0457219,-0.07583901,0.06551961,0.051242642,0.004082043,0.005151516,-0.029551422,-0.012775356,0.016487056,-0.07178376,0.022898078,0.09633461,0.015576493,0.03505948,-0.10129938,-0.03418978,-0.10033512,-0.047034085,0.101282194,0.023350608,-0.016805844,-0.06896096,-0.01075229,-0.0033522435,0.11947777,0.008573926,0.02054298,0.026241405,-0.038796317,-0.003436188,0.041847438,-0.018847134,0.035572927,-0.050674878,-0.049932208,-0.053950477,0.027783884,0.036183383,-0.00051702553,-0.0037547005,-0.0032572967,0.035957467,-0.029976355,0.0034385845,-0.0058801095,0.016449103,-0.016050568,0.05715945,-0.011386818,-0.002375691,0.036016,0.017789245,0.046663564,0.0540069,0.025397785,-0.08357389,-0.0004990845,-0.027083011,-0.11688287,0.038803298,0.019802887,-0.04840069,0.029845808,-0.056624684,-0.051303525,-0.01816079,-0.009151422,-0.092584245,-0.035821676,0.047874402,-0.005427223,0.032792147,0.04093913,-0.0037137184,0.0061394516,0.024112195,-0.047700886,0.0193372,-0.076785155,0.11114245,0.0030769529,-0.04648467,-0.067520104,0.03460293,-0.0059244614,-0.0038908622,0.017120635,0.09857979,0.0022457165,0.012636699,-0.102515005,-2.0483276e-34,0.09508783,-0.031070963,0.030137891,-0.0016017662,-0.0075822133,-0.047292616,0.018275723,-0.0036618242,-0.037151072,-0.06718476,-0.034663998,-0.11161222,-0.0025892137,0.05707636,0.090179406,-0.05418977,-0.032536604,-0.04067834,0.04948208,0.010996974,0.029142585,0.04099463,-0.06460451,0.007056249,0.052138913,0.056118235,0.019821396,0.015857035,0.0888598,-0.010482237,0.04517238,-0.10410943,-0.066741906,0.028248606,0.11331925,-0.03130415,0.004353091,-0.043282002,-0.0006362328,0.078287385,-0.009747401,-0.017274933,-0.007312025,0.0063124583,0.022988345,-0.094109476,-0.034903053,0.09074983,0.064808875,0.0470877,-0.0071756965,0.0017679953,0.13310406,0.07971878,-0.08668062,0.021681268,-0.056706976,0.011850713,-0.050088678,-0.039952148,0.0055086603,-0.029789913,0.05902607,0.041737467,0.011588122,0.012499947,-0.010615544,0.044974875,0.06769139,0.037639726,-0.051326416,-0.0033101651,-0.03856202,0.021442818,-0.003713369,0.0015046815,-0.06609639,0.03142708,0.03822643,0.03141647,-0.024499424,0.022481838,-0.01729541,-0.05333928,-0.039370958,0.06314427,0.012011,-0.050977994,-0.024021314,0.057257853,0.02881545,-0.025364261,-0.030195465,0.03245836,-0.034955863,-1.1603549e-33,0.018659895,-0.13217443,0.10160015,-0.055471584,-0.087936305,0.06571577,-0.021853572,0.021799996,-0.102451116,-0.030753486,-0.0129536595,-5.2924195e-05,0.030359194,-0.08331409,-0.03412529,0.056537975,0.055564567,0.040119685,-0.03253884,-0.0597732,-0.040582918,0.03563905,-0.0045832996,-0.106203124,0.02826392,0.06536275,0.024471166,0.095723,0.018496294,0.059086423,0.037374627,-0.007939684,-0.08752465,-0.04614502,-0.039229263,0.07181792,-0.034880463,0.025695458,0.020271631,-0.012055851,-0.032885164,-0.02331147,-0.030975766,0.09890992,0.062020864,0.053446796,-0.022800228,-0.012655477,0.10001779,-0.0075401207,0.02242775,0.010046958,0.04913782,0.019191097,0.00050491624,-0.07210595,-0.006552722,-0.027847944,0.023021823,-0.07543935,-0.008359377,-0.08723659,-0.023413682,0.006688395,0.07101037,0.043197334,-0.036752682,-0.009390978,0.031862568,-0.068172984,0.08655188,0.017831123,-0.026856374,0.110473126,-0.058581464,0.007197057,-0.06998962,-0.09798756,-0.027812751,0.03478118,-0.03305382,-0.019505592,-0.0032360607,-0.06040799,-0.027660184,-0.056513507,0.12083111,0.062962495,-0.00013960426,0.058962736,-0.053804815,0.019877445,-0.0647516,0.008761801,0.06859599,-2.3727672e-08,0.034439992,-0.0897685,0.031483185,-0.046761077,0.0059463386,0.023427162,-0.03438937,-0.065244295,0.008674077,-0.06255433,-0.038167838,0.020657655,-0.018051459,0.035406064,0.050448116,-0.09793842,0.049079835,0.029826712,-0.014226188,-0.069359414,-0.072076745,-0.062114406,-0.09858809,0.0167016,0.037664983,-0.037201338,-0.015187876,0.051322266,0.03671259,-0.016773062,-0.013490272,-0.050077815,0.02976304,0.0015815544,-0.08643464,0.03998537,-0.0313166,-0.02264456,0.033997424,0.009409441,0.04461718,-0.033471145,-0.022569023,0.05767512,-0.016227357,-0.027130099,0.039083008,0.04862779,0.029914746,0.0017773708,0.035023507,-0.041889314,0.018972429,-0.038076293,-0.12702414,0.029151747,0.03249517,-0.018718818,0.009765073,0.021031275,-0.007922819,-0.02293008,0.15578514,-0.051899493 +2.3.2.33,"RCR-type E3 ubiquitin transferases is a class of RING-type E3 ubiquitin transferase (see EC 2.3.2.27) that mediates ubiquitylation of acceptor proteins via an internal cysteine residue. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue on a mediator loop of the RCR-type ligase. The ubiquitin may be transferred to a second internal cysteine before the transfer of the ubiquitin from the RCR-type ligase to the substrate.",384,1.0,-0.07344402,-0.029424187,-0.07163997,0.0038933237,0.11291008,-0.00855367,-0.014450654,0.059992056,0.06548177,-0.09718023,0.016243568,-0.036967117,0.047305375,0.024799956,-0.048078183,-0.027278371,-0.064455375,-0.029005973,-0.034573056,-0.07757846,-0.004066873,0.037308168,-0.019786468,0.011143799,-0.00027551243,-0.031823434,0.020021519,-0.021183487,0.013829048,-0.10123439,-0.001613077,-0.06136668,5.807569e-05,-0.023128625,-0.025094138,0.05973765,-0.05361747,-0.03719233,-0.057539932,-0.028200049,0.08719488,-0.03792826,0.060141556,0.00026453478,-0.010587069,0.04650979,-0.02162808,-0.019947095,0.02780335,0.041032694,0.017603224,0.014649933,0.008346319,0.10269215,0.046031825,0.045767076,-0.04592351,-0.020254012,-0.002816974,0.011557286,0.01861794,-0.0146480175,0.027853325,-0.027532233,0.0255248,-0.05039512,0.08345788,-0.014227992,-0.019853441,-0.056088585,-0.018704467,-0.040023245,-0.12668891,0.03859422,0.02875715,0.065632895,-0.077054106,0.074490815,-0.01685547,0.02357771,-0.00426635,-0.04651911,0.07536843,0.0276263,0.027486686,0.015556514,-0.031474072,-0.09306555,-0.0030887045,0.10622339,-0.0003464386,-0.016067144,-0.011739775,0.031430658,-0.09246395,-0.030575931,0.024824088,0.0890544,-0.018874886,0.011006822,-0.005233909,0.056288373,-0.022792833,-0.05181483,-0.017054128,-0.03585317,0.015892833,0.08530361,0.028710444,-0.010665703,-0.019684467,-0.01892207,0.019099899,-0.023612242,0.003815453,0.10002854,-0.025021086,-0.023358194,0.060885437,0.01664996,-0.0103019755,0.016402414,-0.04419598,-0.007212765,0.011376935,-0.076239645,-0.119478,4.0866043e-33,0.0503495,0.031877775,0.004829309,0.06258734,-0.09486824,0.045923885,-0.0716822,0.03047794,-0.023361849,-0.08711449,0.025371682,0.008392317,0.01366482,0.047810473,0.008633939,-0.11773246,-0.026539471,-0.03599186,0.010186806,0.007826968,0.05244958,-0.003212715,-0.06638091,0.016090598,0.024893673,0.029669829,-0.008375548,0.028705353,0.047293913,-0.007671879,-0.031695697,0.015134564,-0.06800464,0.045872845,0.02145182,-0.016204387,0.08824525,-0.03041613,0.0021583776,0.0448896,0.05622055,-0.05108461,-0.12917782,-0.018757623,0.11638896,-0.07288775,-0.028642876,0.043390516,-0.043702245,0.028007481,0.068192996,-0.05044815,0.08424738,-0.06399773,0.002416581,0.0022752765,-0.040357403,0.0010749263,-0.01568476,-0.0093451,-0.023354972,0.011708317,-0.048348423,0.05843471,0.018399179,0.082186885,-0.04116393,-0.11065028,-0.06526017,0.005334665,-0.02423652,-0.011368884,0.07778706,0.057689775,0.011589107,-0.0028528979,-0.18654771,0.034627296,0.11180091,0.02726596,-0.0632897,-0.01902929,-0.07019791,0.049900863,-0.0598435,-0.026130622,0.041053485,-0.08054623,-0.0091960905,0.012684685,0.128834,-0.032205544,0.028772349,0.08084913,0.033445332,-4.7373657e-33,0.14628498,-0.07989628,0.069484234,0.021198587,0.06519013,0.074946485,0.056399774,0.025278023,0.064518824,-0.06453667,0.098107114,-0.05280785,0.00905021,-0.004495005,0.021189328,-0.09158245,-0.0035895407,0.03067882,-0.02390906,0.024928322,0.07824588,-0.07393345,0.03353991,0.044140354,-0.07336215,0.05900773,-0.016390942,0.07529923,-0.0083145015,0.034067616,-0.12980963,-0.011366507,-0.020214254,0.014433598,-0.071556725,0.0740942,-0.024084538,0.026705686,0.06851955,-0.060551018,-0.00054952333,-0.015723044,-0.07526956,0.06905857,0.023744887,0.08083247,-0.0020634625,0.022709021,0.012479233,-0.04196117,0.049669337,0.054050103,-0.055240806,-0.00040684643,-0.055234164,0.073402666,0.092782564,-0.058481924,0.04716046,0.012726118,-0.042825073,0.0477381,0.020893382,0.049114715,-0.037885185,-0.021442018,0.050686695,0.007837656,0.056002796,0.029509973,0.08723156,-0.036298387,0.102329,-0.042409908,0.054499358,-0.028144216,-0.02795488,-0.03200681,-0.008095682,-0.056413643,-0.058802962,-0.03863839,0.02717663,-0.030967433,0.04321978,-0.033128686,0.04060283,-0.025183603,0.009191048,0.011800607,-0.05960712,-0.00012544886,-0.0017826011,0.044905584,0.051897686,-4.511183e-08,0.068255335,-0.077235416,-0.0354176,-0.05802294,0.067351766,0.02099018,-0.03329074,0.007563126,-0.0020141157,0.011071506,-0.029730521,0.020418229,-0.060188346,-0.06103266,0.1147321,0.023326714,0.10541187,0.05068872,0.010445262,-0.06439655,-0.033899676,-0.03146825,0.014003845,-0.049219385,-0.029031355,-0.024440326,0.040355697,0.095268406,0.009811282,-0.035495773,0.0069175716,0.0150783295,0.0357982,0.0103314575,-0.05233538,0.021264961,0.008222603,-0.07142949,-0.008806924,-0.019230476,-0.030130254,0.00071095466,-0.11390293,-0.017757239,0.03553339,0.03575524,0.04825565,0.053104345,-0.070383,-0.073327,0.012820882,-0.051091272,-0.02536429,-0.069732614,-0.048938908,0.06454735,-0.023875743,-0.046586033,0.015734928,-0.04354234,-0.07526952,0.0071267853,0.057512663,-0.0540124 +2.4.1.371,"The enzyme is involved in the biosynthesis of polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a. The enzymes consists of two domains that are responsible for the 1->2 and 1->3 linkages, respectively.",384,0.99999994,-0.009950981,-0.078403264,-0.07616899,-0.015107026,0.028098704,0.017705295,-0.0149378525,0.04321328,0.08788811,-0.06920866,0.00094441033,0.016885344,-0.09831524,0.017838351,-0.040943123,0.017758176,-0.051681697,0.028529616,-0.021103159,-0.09632205,0.15122288,-0.035448834,0.016635654,-0.0629709,0.019786,-0.048889786,0.020261565,-0.03276929,0.010344273,-0.080044575,-0.030050406,-0.02864167,0.015877634,-0.030313216,0.06768076,0.06451673,0.0478621,-0.10378539,0.07850157,0.010630407,0.08485489,0.045483064,0.00072592706,-0.0130742155,-0.007210728,0.002656758,0.007161624,0.01377915,0.0050789635,-0.03656113,-0.039702386,-0.068846196,-0.07791514,0.0021949073,0.046243057,-0.009522852,0.01587274,-0.09947573,0.009852026,0.02650542,0.043447796,0.017706873,0.051773615,0.025432345,0.015378222,-0.07906172,0.038539696,-0.02998758,-0.061612982,-0.02770787,-0.043790307,0.0085632,-0.04233825,0.011959439,0.04463861,-0.03184867,-0.04301936,0.0034506596,-0.00976298,0.053938366,0.07061349,-0.00595672,-0.0197755,0.10598837,-0.0142123075,-0.010209358,0.030149888,-0.0018235296,0.07212718,0.09325494,-0.042140994,-0.06917097,0.037854888,-0.03792387,-0.049982116,-0.035539005,0.05844454,-0.0056621954,0.005668611,-0.0122018205,-0.06850357,-0.010891581,0.0839928,-0.0463174,-0.033572227,-0.01039089,0.022872292,0.11075414,0.0066412995,-0.01114991,-0.025410976,0.0029659127,0.037777882,0.0052771615,-0.07153259,-0.031626575,0.023611397,-0.059752718,-0.0036059346,0.030773694,-0.0053615025,-0.060705326,0.021716695,0.065549105,-0.018389268,0.030815585,-0.118952304,1.118495e-33,0.07440508,0.022909224,0.018547684,-0.059608974,0.03773002,-0.031581953,-0.0094391,-0.050786104,-0.09644728,-0.0047085234,-0.13678814,-0.1298234,0.015755426,0.043848734,0.046202134,-0.0015323574,-0.027483026,-0.022216007,0.034557194,0.023296116,-0.016217796,0.05266519,-0.023164852,0.031376503,0.07301712,0.0031466302,-0.0766894,0.0027948683,0.019764919,-0.003746501,0.08018886,-0.045863956,-0.09520219,0.08877877,0.12862009,-0.0029040494,-0.014795018,-0.041867476,0.006965197,-0.0051778075,-0.030475052,0.044945203,0.019923002,-0.037564795,0.056902353,-0.035934925,-0.03986736,0.10241079,0.0385783,0.07492423,-0.008795332,0.03868939,0.089786336,0.0072266688,-0.023421437,-0.03756536,-0.056959335,0.036192864,-0.03241575,0.055952717,0.0374679,0.0006640419,-0.044098005,-0.002490667,-0.001234132,0.026811775,-0.020199407,-0.03867029,0.04464206,0.0330414,-0.07580179,-0.05618874,-0.033044178,0.026608774,0.03004205,0.0062505733,-0.07252091,0.017699098,0.05499485,-0.018304422,0.05741746,-0.005044677,0.028148128,-0.032504305,-0.06286672,0.035955947,0.011566768,0.01335796,-0.05346,0.092014104,0.077036545,-0.07980952,-0.013994758,0.075091824,0.028298616,-3.099992e-33,0.04305178,-0.1108443,0.09069857,-0.10307232,-0.10939988,0.030776562,-0.040130593,-0.025597915,-0.008418514,0.036345124,0.02358535,0.01796363,0.03152202,-0.014561946,-0.012079846,0.004347699,-0.040102467,0.115032494,-0.02641145,-0.021601131,-0.014793147,0.0356698,0.054693155,-0.006433045,0.020841906,0.024919182,0.011178608,0.085937195,-0.02551077,-0.009180125,-0.04110563,-0.035771273,-0.04219335,-0.020153575,-0.0776161,-0.00060079515,0.002824993,-0.008915462,0.11638059,0.03706607,0.013703215,0.0045955908,-0.0011637191,0.00032944573,0.0020837714,0.05364831,-0.068328634,0.064236335,0.0034383468,-0.053238265,-0.038166057,0.004657845,0.024367355,0.0077294274,0.01744614,0.041659035,0.056138005,0.006158714,-0.012905728,-0.08458485,0.003981334,-0.025247918,0.06426241,0.05892233,0.024025401,0.0067590293,0.007857762,-0.016813723,0.0129585685,-0.02964068,0.0053427457,0.028161118,-0.06397194,0.004948153,0.016042246,-0.07426657,-0.12530316,-0.01789103,-0.003679044,0.021944975,-0.035201788,-0.007100634,0.0043098386,-0.044891622,0.042449445,-0.05261046,0.10934207,0.11949714,0.057182014,0.0378128,0.015578058,0.025923282,-0.06645498,0.07770146,0.041227024,-3.504101e-08,0.0147395395,-0.09532924,-0.0019930832,-0.09435409,-0.056827433,0.007173799,0.024129072,0.018734166,0.00095144205,0.042884275,0.029504023,0.12830706,-0.031874288,-0.017640937,0.06403201,-0.0341106,-0.017728174,-0.005386265,0.00789972,-0.03432674,-0.023262197,-0.05184049,-0.065422066,0.08948946,0.03370403,-0.07621886,-0.016800439,0.029848952,-0.0029629238,0.022117479,0.005044197,0.033679754,-0.025748387,-0.11230451,-0.12127242,0.0017503332,0.0034401838,-0.07261268,0.002180241,0.024015484,0.08851649,-0.030811016,-0.045504402,0.010519839,0.08684795,0.102422915,0.028511116,0.023881854,-0.045468334,-0.014069006,0.04688021,-0.035217166,-0.042128146,-0.016855864,-0.15152174,-0.071165405,-0.004243625,-0.03683731,0.025330447,0.02063328,-0.015039798,0.05571473,0.17870618,-0.092465974 +2.4.1.372,"The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends the glucan chain by an alpha(1->3) linkage.",384,0.99999994,-0.047372237,-0.07504528,-0.05848516,-0.01347436,0.06925815,-0.015684955,-0.0041512814,0.014967349,0.04538722,-0.018086264,0.06094868,0.09504865,0.015070453,0.010324771,-0.120651335,-0.008796533,-0.07610522,0.011087353,-0.09286307,-0.048721127,0.1826662,0.005410727,-0.013266423,-0.013551634,0.08182586,-0.054271404,0.01620812,-0.042023733,0.017237818,-0.057906523,-0.07896406,-0.05608299,-0.045553602,0.022410996,0.03578782,0.06185151,-0.039556794,0.040497143,0.031854022,0.018511128,0.012660781,-0.004423046,0.0019223298,0.05946708,-0.06636356,-0.03505837,-0.12194559,0.08805424,-0.044662215,0.043216046,-0.0010852292,-0.050626114,-0.07961204,0.07003757,0.026531853,0.036055513,-0.022266056,-0.02798182,0.029201165,0.04413352,0.050492674,0.011574296,-0.07432821,-0.057107013,0.0029922433,-0.054791108,0.08241208,-0.029237555,-0.046426423,0.021268502,-0.01784534,0.0019733533,-0.012213586,0.05066805,0.074204035,-0.012185353,-0.015820032,0.03213538,-0.025052963,-0.034200545,0.0696957,-0.009459087,0.08810206,0.086999066,0.016125357,0.0051717474,-0.005506614,-0.010257551,-0.012637246,-0.004626015,0.03289563,-0.081675164,-0.02080376,-0.08636646,0.00073012686,0.032127466,-0.015306692,0.003737567,0.107892506,-0.05865668,0.0060014753,-0.0344158,0.053524517,-0.021337673,-0.057126887,0.06622621,-0.040270925,0.07085448,0.06750981,-0.056590296,-0.015803652,0.029853188,0.022059204,-0.00041255064,-0.067923844,0.015618997,0.038728654,-0.028908916,-0.046119627,-0.027024528,0.03831611,0.070907876,0.12516966,0.053470843,-0.04409302,0.030289141,-0.07240428,-9.1681167e-35,0.0650819,-0.0071091875,-0.017136322,-0.018031504,-0.063998796,-0.045128163,-0.09435648,-0.03178493,-0.052277863,0.062289197,-0.11942025,-0.029305136,-0.048382133,0.08002834,-0.016256535,0.068979144,0.028565975,-0.0022732066,-0.0036787228,-0.028688261,0.01094735,0.10449269,0.0080630025,-0.008023225,0.037959557,0.039731953,-0.076333076,0.0467512,0.010654095,-0.0213444,0.013610493,-0.021683143,-0.038409337,0.07343289,0.04170453,0.053658165,0.004608908,-0.026396407,0.05899583,-0.021485273,0.012010444,0.012067617,0.054928914,-0.060170416,0.07579079,-0.0044016093,-0.008252513,0.03415341,-0.030906076,0.08697727,0.024111502,-0.011784713,0.04675406,0.00045902,-0.05920976,0.03513387,-0.014543212,0.016466836,0.038498297,0.04988093,0.02000195,0.023500936,-0.034551498,-0.032624956,0.037082333,-0.007930455,-0.09221149,0.020079892,-0.03013377,0.11366849,-0.0725829,-0.0019046727,-0.034774486,0.08395593,0.048859768,-0.047852848,-0.10346564,0.012323268,-0.0030366466,0.022839364,-0.056984995,-0.035594217,-0.065057956,-0.027354887,-0.12786032,0.024327623,-0.05362092,-0.14743643,0.018503541,0.064546764,-0.05070998,0.0048800143,-0.032366876,0.060197193,0.054259703,-2.8501727e-33,0.08145682,-0.04152542,0.09579843,0.030652108,-0.048400126,0.05616794,0.0064762314,-0.037394773,-0.01127496,0.019457877,0.016052965,0.068401545,-0.09990229,-0.048504226,0.04638407,0.013494684,-0.07184863,0.087667994,-0.03718856,0.035138622,-0.0003966481,0.104317605,0.0084883245,0.00936589,0.053639367,-0.04157177,0.0688777,0.08182386,0.015046654,0.0051416787,0.005315825,0.00571951,0.021918096,-0.023749262,-0.059890684,0.011664828,-0.0047764317,-0.0015390987,0.009346519,0.021552663,0.019885529,0.052479003,0.0105408905,0.003937403,0.06757271,0.012687653,-0.06328272,0.02603226,0.0036028663,-0.08225334,0.037742957,0.006173541,-0.0073208814,-0.017946823,0.06339089,0.0574498,0.037037306,0.0319874,-0.03790872,-0.0052664215,-0.04193602,0.0010893686,0.016832436,-0.04170753,0.08418131,-0.040868916,-0.012210046,0.0028851386,-0.025449255,0.0800352,-0.002953693,-0.028880367,0.011383906,-0.03407529,0.014458301,-0.109234825,-0.09996735,-0.032480545,-0.05208835,-0.09131941,0.012261754,0.0030415389,0.038412042,-0.023845445,0.0053939614,-0.026943414,0.045821283,0.076310545,0.037581496,0.0138875,-0.06895968,0.00354534,0.0036576902,0.015467808,0.0007560484,-3.9484704e-08,0.027989374,0.04317129,-0.054827392,-0.05431627,-0.038986016,0.018588107,-0.071846396,0.069091916,-0.005319009,0.036973316,-0.04206291,0.12757924,-0.04465669,0.014155716,-0.034875963,-0.022535203,-0.029884608,-0.037232272,0.007865731,0.0008884571,-0.09499496,-0.028120235,-0.082581446,0.09129767,-0.010512062,-0.09401368,0.040907312,0.1331175,0.004457528,0.03229658,0.03428544,0.0393333,-0.07184097,-0.058252584,0.024556337,0.03151359,-0.06944236,-0.019149102,0.05033145,0.05988573,0.086109295,0.0006776279,-0.05918962,0.021374624,-0.025471343,-0.06457706,-0.007541128,-0.05551426,-0.016364709,0.08804029,-0.0066800527,-0.03517865,-0.0787498,-0.030760737,-0.032035008,-0.06366352,0.025755052,-0.016261768,0.040290978,-0.09653297,0.0231441,-0.0069217375,0.11897251,-0.04520062 +2.4.1.373,"The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme introduces alpha(1->2) branches into (1->6)-alpha-D-glucans.",384,1.0,-0.03092944,-0.08911143,-0.055672854,-0.016841093,0.07208611,-0.019347634,0.0012483137,0.019417087,0.049963873,0.00702675,0.048475403,0.11590114,-0.011485163,0.010667355,-0.12138471,-0.007900684,-0.09358224,0.015894873,-0.10425642,-0.039567046,0.16754308,-0.015747378,-0.015930353,-0.013531548,0.08456533,-0.04300833,0.023007905,-0.047088273,0.028061666,-0.065029755,-0.070579946,-0.05779544,-0.023487993,0.029881662,0.034365267,0.05837235,-0.037728257,0.032611538,0.020891402,0.027848486,0.018190509,-0.015810268,0.008189008,0.057617914,-0.06727348,-0.034658417,-0.13549046,0.09814787,-0.03197932,0.05292602,0.009039203,-0.06788776,-0.090172775,0.060017113,0.0016551185,0.0563938,-0.006661681,-0.029211199,0.02690036,0.06497676,0.06288327,0.0113811465,-0.06751868,-0.04328799,-0.0031346069,-0.051069483,0.082756594,-0.02850317,-0.04292176,0.0020205923,-0.020053776,0.011305211,-0.018797662,0.041651376,0.07064956,-0.022946643,-0.016623454,0.025160687,-0.014846893,-0.041291196,0.06821264,-0.0046207006,0.07688026,0.08709071,0.0054977126,0.018304966,-0.009032224,-0.0148025425,-0.00667517,0.020699723,0.01814241,-0.07158161,-0.010868544,-0.09709486,-0.008032052,0.042547923,-0.015307324,0.01783142,0.10539851,-0.057658374,-0.0017309894,-0.023280937,0.04709719,-0.031455636,-0.06588928,0.046867535,-0.039812643,0.06125518,0.06508204,-0.039695557,-0.002687888,0.023052424,0.029734725,0.010955774,-0.056501597,0.009950413,0.047640327,-0.01731745,-0.048297238,-0.013754424,0.030806966,0.06618057,0.13435075,0.061207797,-0.05178241,0.032409534,-0.06839738,-4.478737e-34,0.073487915,0.009390901,-0.02426839,-0.013122922,-0.068323515,-0.036202658,-0.100667216,-0.04207806,-0.056481272,0.072360076,-0.12829784,-0.034310967,-0.03674725,0.070019156,0.00059210794,0.05371622,0.033691,0.0021724165,-0.01236844,-0.024664037,0.013973948,0.09198198,0.009459852,-0.013964262,0.041406278,0.02854721,-0.08977314,0.065213025,0.007726366,-0.024803968,0.009762638,-0.0094484035,-0.04172305,0.08156833,0.037247244,0.048312545,-0.0045245797,-0.017093148,0.058832467,-0.021995245,0.015504936,0.010770884,0.05862644,-0.0485969,0.08647427,-0.009754295,-0.010167354,0.03358048,-0.015076441,0.07901362,0.010389412,-0.0013883521,0.061738215,-0.006299227,-0.053856343,0.022231659,-0.019708203,0.011135547,0.037650257,0.06868849,0.03214789,0.03326487,-0.0382194,-0.018814854,0.018202027,-0.012006176,-0.07085065,0.017105035,-0.037131,0.10779512,-0.07871524,-0.009849701,-0.032935657,0.0638361,0.044967383,-0.054949358,-0.08101526,0.030797392,-0.0048128683,0.009189377,-0.063367,-0.021548055,-0.06556743,-0.017094832,-0.100648984,0.03454219,-0.05199911,-0.13995829,0.0040344726,0.056408502,-0.040368367,-0.0020366167,-0.05145356,0.06806519,0.07057003,-2.4300513e-33,0.06397378,-0.058028523,0.087948136,0.033382416,-0.061669525,0.0703154,0.012724152,-0.03655168,-0.008135455,0.008876731,0.018722951,0.072443835,-0.12008733,-0.058213215,0.041389283,-0.009768511,-0.0573941,0.09609264,-0.02694561,0.025919473,0.004846724,0.09805461,0.008160607,0.016867237,0.067861944,-0.04970553,0.0835101,0.078290544,0.017399924,0.0045892633,0.014767275,0.0052447207,0.019034294,-0.022781475,-0.06405185,0.010530238,-0.006182282,-0.0021481588,0.011383113,0.02507367,0.0074859792,0.05138376,0.01181868,0.004116242,0.06096408,0.007545612,-0.05752572,0.026977967,-0.009265147,-0.06551405,0.029074768,-0.0004970456,-0.015409198,-0.0020834785,0.047861233,0.041965447,0.034064997,0.048478324,-0.046610583,-0.009764176,-0.046842374,0.001055526,0.012693407,-0.04360214,0.072350554,-0.0575486,0.0033297786,0.019615574,-0.034209337,0.07268642,-0.010612773,-0.03203603,-0.004609292,-0.028996935,0.01814686,-0.12111832,-0.091445796,-0.034379236,-0.03092874,-0.08751231,-0.02184492,0.023385243,0.02317948,-0.0065168627,0.02610998,-0.0374249,0.056162465,0.081432156,0.039900847,0.03587303,-0.06016779,0.0059141647,0.0057664756,0.016148102,0.0076714843,-4.1325062e-08,0.026909187,0.038448833,-0.051662445,-0.05010733,-0.02035077,0.010843072,-0.08347238,0.06808262,-0.01385071,0.018686766,-0.051091127,0.14162147,-0.047759093,0.024367962,-0.032875843,-0.022447038,-0.024446256,-0.02188632,0.00035580772,0.0011897818,-0.089769535,-0.04017983,-0.0795583,0.081925295,-0.019737734,-0.10706092,0.042191662,0.13677296,-0.008674031,0.03503424,0.028402373,0.027403798,-0.07455653,-0.06876906,0.028016517,0.044883773,-0.061823647,-0.031093622,0.044832367,0.04432033,0.07757399,-0.034561045,-0.03344554,0.020150164,-0.032929245,-0.05985164,-0.0074799457,-0.04932615,0.0069991923,0.08236872,-0.005325372,-0.032340553,-0.07285852,-0.046434205,-0.027383221,-0.056052286,0.039016444,-0.035134934,0.056013215,-0.09082218,0.04291168,-0.0059162634,0.118184336,-0.060383953 +2.4.1.374,"The enzyme, characterized from Leishmania parasites, is involved in synthesis of mannogen, a beta-(1->2)-mannan oligosaccharide used by the organisms as a carbohydrate reserve.",384,0.99999994,0.033446413,-0.0056206184,-0.050715074,-0.08636456,0.007482293,0.029950175,-0.029707545,0.0077674217,0.017298134,0.09981137,0.042965513,-0.024958797,-0.052030828,-0.0070521985,-0.0795981,-0.0057957065,-0.0075659584,0.024900474,0.043815292,0.021088203,0.07019487,0.014344522,0.07080708,0.0031424882,-0.010637415,0.025833912,0.07183272,-0.07287839,-0.041168485,-0.089125276,-0.032537803,-0.04096338,-0.0007651081,-0.06403324,0.009013093,0.049467597,0.060734395,-0.031700622,0.031454533,-0.039686993,0.02252413,-0.08402289,-0.03560316,-0.039141823,-0.04998948,-0.0814943,-0.042395346,0.100323424,0.081576206,0.0060708197,-0.048188604,-0.04849947,-0.008816484,0.017535275,-0.022335561,0.023759892,-0.042475004,-0.0153514,-0.012279702,0.040842887,0.005830908,0.06129589,0.035828833,-0.049533308,0.056700654,-0.11818941,-0.023577912,0.0006816664,-0.027372733,0.046149768,-0.018425167,-0.049556307,0.015639223,-0.0056495713,-0.008908117,0.011540705,0.042500798,-0.026921261,0.06903396,0.02020856,0.05083687,0.03176219,0.06875258,0.01909533,-0.023327626,-0.012968746,0.0062463433,0.05632351,0.13305986,0.00026688242,-0.0036361741,0.00591161,0.030542677,-0.0018391646,-0.044297088,-0.038061965,0.012114986,0.0608201,0.1353258,0.0010990744,0.07581131,-0.034708377,0.016695593,-0.07037436,-0.016726343,0.029440463,-0.006149111,0.047518365,0.042718332,-0.007552855,0.012893929,0.020569824,0.00064219633,-0.009632013,-0.0784966,0.06198839,0.010079038,-0.12166618,-0.061364006,-0.014689001,0.030788751,-0.01169732,0.05132231,0.03908544,-0.011686797,0.028629264,-0.09453704,-2.2861409e-33,0.035620037,-0.022143286,0.10429264,0.06510186,0.06669501,0.016283697,-0.06956477,0.031155705,-0.108055644,-0.036282714,-0.10465003,-0.039012313,-0.034423813,0.108728014,-0.002142409,0.06857875,-0.027021008,-0.019813731,0.045050308,0.017316926,-0.052052613,0.07901811,-0.023657026,0.01581017,0.10047971,0.07399155,-0.032394335,0.0020169164,-0.012044319,-0.002651929,0.08030802,-0.06657251,-0.081973925,-0.0011646686,0.014903011,0.014156569,-0.012438411,-0.02597708,-0.007520527,-0.050133258,-0.011003429,0.011670953,-0.002583336,-0.08121504,0.0007484798,-0.026946155,0.054737862,0.011952813,0.0033800432,0.022334725,0.09532908,-0.0031582147,0.028987087,0.045494244,-0.037794486,0.09438413,-0.061603796,-0.012872602,0.062470753,0.04962552,0.010418509,-0.0021606865,-0.03824974,0.005201229,-0.027236423,-0.0017565225,-0.011945021,0.009383183,0.032048516,0.006407646,-0.07518864,-0.056928266,0.007450832,0.041408174,0.030805556,-0.026096346,-0.0030852421,-0.0413426,-0.033715,-0.0123373475,0.07665266,-0.010995919,0.008076485,0.009550959,-0.0977107,0.060911775,-0.08938665,-0.04669358,-0.029523555,0.033197053,-0.00078691053,-0.040792942,-0.1492867,0.02025798,-0.04233023,-1.2874981e-33,0.116045564,-0.109789744,-0.0034470877,-0.0861069,-0.04888665,-0.0003914189,0.032279246,-0.023669928,0.002204713,-0.041407447,-0.00011624929,-0.029708924,0.059388418,-0.00812781,0.026434248,-0.018272085,-0.05763377,-0.0041604773,-0.014306388,-0.0023618073,-0.087939024,0.122361794,0.060022533,-0.03131333,-0.020600377,-0.016549919,-0.014597747,0.12698951,0.027252836,0.061721236,-0.007930367,-0.03495267,0.0131092295,-0.0600878,0.014131339,-0.005221073,-0.06052385,0.009070251,0.018002471,0.05605805,-0.09179734,0.032200348,-0.011010445,-0.059285607,0.020005263,0.071357764,-0.045899313,0.013514287,-0.040202364,-0.050907902,0.038935952,-0.032369606,0.022693716,0.017748214,0.032844048,0.0035213912,-0.059661973,-0.003324229,0.064771265,0.0061837663,0.015292447,-0.03859691,0.033686224,-0.036362175,0.0734835,0.014997712,-0.088864826,0.0281947,0.04782666,0.018156594,0.049625095,0.037938382,0.012570712,0.07717633,0.042230904,-0.005354233,-0.13619818,-0.03965634,0.026861658,-0.040021196,-0.04294112,-0.030866455,0.07255802,-0.011895596,-0.023474522,0.057097442,0.07560048,0.08747608,-0.061692,0.10341752,-0.010651233,-0.034578625,-0.06473557,0.12753299,-0.04056634,-3.037384e-08,0.055756856,0.016936101,0.05684742,-0.10426927,-0.061112408,0.035983447,0.01255295,0.026308931,0.038655188,0.01276009,-0.043938946,0.09478398,0.07003566,0.024744665,-0.06894891,0.020229252,-0.019571794,0.023925431,-0.054243155,-0.03900669,-0.10758745,0.076946236,-0.07906461,0.037382703,-0.0046915878,-0.012602344,0.023249269,0.029471438,0.010943816,-0.032471206,-0.07740312,0.096582495,0.025294933,-0.10051189,-0.049624585,0.03857297,-0.08738338,-0.05979903,0.04600387,-0.061463,0.07107084,0.0057754875,0.020217681,-0.058182165,0.0039135762,0.028123002,0.013162238,0.012016913,-0.0036008712,-0.026579754,0.0077280873,0.083847284,-0.09673844,-0.041145682,-0.065487176,-0.08819089,-0.07726604,-0.046208464,-0.00030207625,-0.09992393,0.01112669,-0.02047967,0.10737826,-0.04689216 +2.6.1.118,The enzyme participates in an L-lysine biosynthesis pathway in certain species of archaea and bacteria.,384,1.0,-0.050500475,-0.07910823,-0.09236146,-0.011220173,0.13573228,0.044692144,-0.12939963,-0.008638929,0.050686203,-0.0032220057,-0.017425928,-0.061297894,-0.01001792,-0.023032546,-0.04070168,0.064166814,-0.14414318,-0.028386606,0.017662209,-0.022734389,0.10848378,0.1058492,-0.056113947,0.028699324,0.008095853,-0.053974498,0.06525819,-0.07271356,-0.04957493,-0.011701748,-0.004967078,-0.08322363,0.07938537,-0.07836678,0.03684916,0.09636303,-0.04555232,-0.061633572,0.1174347,0.011138761,0.022458373,-0.031030143,0.013592881,-0.041462533,-0.06627596,0.049858112,0.036577787,-0.004899935,0.0073387465,0.03265537,-0.028183809,-0.023783544,-0.06984694,0.004859227,-0.032049272,0.03308758,-0.059524838,-0.020806795,0.035156645,-0.016008608,0.05211115,0.040442083,0.03128246,0.036900826,0.00303862,-0.0915855,0.023880498,-0.021186069,0.04951486,-0.10188581,-0.03759368,-0.086051285,-0.004518537,0.045176916,0.028169101,0.026370399,0.017927399,0.0146225775,0.009198237,-0.038321357,0.024799326,-0.052311223,-0.0068872496,0.0671916,0.031256057,-0.07762132,0.018317332,0.05805336,0.07462752,-0.011397244,0.060287677,-0.08488568,0.0053595332,-0.026814522,-0.043670364,-0.020379575,0.049759474,-0.02846373,-0.034433413,-0.040717,-0.039927263,0.023418797,-0.009926407,-0.032774016,-0.044755895,-0.043677676,0.009556593,0.117333226,0.0059429766,-0.045730654,0.0627649,-0.0035653152,0.08581915,0.06454111,0.0027879206,0.06264507,0.040033687,-0.07965455,-0.08969535,0.03513854,0.0062526474,0.0028220473,0.06933424,0.0647008,-0.07442125,0.07319191,-0.12697728,-1.0196868e-33,0.077959575,0.025908845,-0.011963476,-0.07350843,0.04928495,-0.018382773,-0.07240413,-0.020802198,0.009251891,0.011735433,-0.060620572,-0.07689095,0.084588006,-0.009174267,-0.057050213,0.04837467,-0.027531248,-0.03385016,0.005915189,0.06659735,-0.051603034,0.025324015,-0.0040495605,0.04428467,0.037552733,0.029162161,0.077623,-0.014242526,0.015129708,0.008246803,-0.027216887,-0.15730385,-0.05781221,-0.02187011,0.1138775,0.012748585,-0.010148737,-0.05499444,-0.027197212,-0.027169561,-0.009797419,0.051073298,-0.026255775,-0.038914975,0.038497217,0.028913751,-0.027981728,0.099954896,-0.030534932,0.0716354,0.053555932,-0.058333986,0.076751225,-0.024376739,-0.09032111,-0.0052852533,-0.055562396,-0.0040410464,0.029692842,0.030354677,0.034977015,0.06511577,0.031704713,0.07667509,0.030462679,-0.011740069,-0.012724091,-0.0111724725,0.0061428878,0.03686735,-0.052756343,-0.06485658,0.076221906,0.0025825405,-0.0013214996,-0.03849988,-0.07464859,-0.056925472,0.011188974,-0.010759391,0.0097967675,-0.05178079,0.006458616,0.01842696,0.01807891,-0.013648815,-0.029280782,-0.045018237,0.0015978629,-0.013664819,0.027489726,-0.055371683,0.0052624783,0.07097999,-0.052537836,-1.48851325e-33,0.06283702,-0.14102781,0.05733331,-0.08116541,-0.026169436,0.035852507,0.009578153,-0.023896625,0.036838774,-0.023410378,0.057809323,0.02184523,-0.012285319,-0.047793373,0.051484194,-0.030092718,0.0626554,0.026119933,0.019909387,0.047914762,0.0692048,0.004552637,0.012784019,-0.023047049,0.05516613,0.010578574,-0.02109446,0.119813226,-0.00014403283,0.007618758,0.009048075,0.029196445,-0.031429656,-0.10243771,-0.047412433,0.05809062,-0.004803147,-0.037157036,0.06167111,-0.0052916883,0.041288853,0.0021612926,0.0038452798,0.050418112,0.011891235,0.01741071,-0.04189775,0.005826401,-0.0006139407,-0.07812205,-0.012908841,-0.06812399,0.06667694,-0.0011218792,-0.019047566,0.029827932,-0.035110187,0.1087969,-0.027879933,0.004480623,-0.02952796,-0.059981752,0.005052858,0.028947446,0.0055851275,0.021627607,-0.040754672,0.049779642,0.006741993,-0.021581985,0.09394287,-0.0017135609,0.066648744,0.12091118,-0.029861003,-0.023700453,-0.07554606,-0.12041086,0.031923305,-0.032441083,-0.047267456,0.010237434,0.043093313,-0.06532765,-0.03693011,-0.098611996,0.029593168,0.109239444,0.034615394,0.014414004,-0.0092848195,-0.053025976,-0.03237911,-0.033553787,0.07297712,-2.3804011e-08,0.038945675,-0.035614528,0.054492563,-0.014115395,-0.045442693,0.037258692,0.02488788,0.04557829,0.0042462773,-0.030162793,0.03905173,0.031355884,-0.017117871,-0.020955093,0.022198388,0.0870617,-0.033523895,0.06767847,-0.04452901,0.019325694,-0.011274859,-0.01775779,-0.038008638,0.018612476,0.03987818,-0.071963914,-0.019426491,0.009587559,-0.007705621,-0.07286004,0.022739317,-0.0037237545,0.029061118,-0.055773593,-0.1069441,0.022350417,-0.059699122,-0.060256075,0.052893385,0.01565954,-0.034033794,0.05240939,-0.085379004,0.02121983,0.015683712,0.04256898,-0.0010917148,0.04486103,-0.019730221,-0.015911596,0.046358693,-0.048242006,0.029636336,-0.054410633,-0.030259384,-0.019883465,-0.038763173,-0.0384631,0.001482148,-0.04801058,0.0135809975,0.06321317,0.17229593,-0.07508088 +2.7.1.230,"The enzyme, found in some bacterial species, inactivates the antibiotic amicoumacin A by phosphorylating it, conferring resistance on the bacteria.",384,1.0,-0.08049007,-0.02022536,-0.07012848,0.0039171195,0.06039794,0.026570728,-0.055497844,0.093960255,0.0735195,0.026432797,0.049930826,0.018764038,0.049989462,0.06668281,-0.024136895,0.061112057,-0.0701781,0.03177384,0.016980648,-0.06225651,0.00328973,0.029442715,-0.024908714,0.058033533,-0.0033589124,-0.001760622,0.02109122,0.072501376,-0.017099269,-0.048777767,0.02710012,0.002788323,0.054303844,-0.026403654,0.022558566,0.015481075,-0.036402196,-0.05440625,0.09896397,-0.014193319,-0.031113481,0.0046462663,-0.04246067,-0.07299851,-0.013465037,-0.0034916797,-0.06317889,0.031030443,0.08069622,0.03243059,-0.07375536,0.0059897676,-0.072125845,0.07601921,0.07506084,0.022359092,-0.080794595,0.00591497,-0.022944424,0.01550867,0.03269182,-0.007878093,0.054257486,0.083906375,-0.08292507,-0.07436776,0.014159455,-0.05853293,0.05334813,0.025882613,-0.06750705,-0.094101615,0.0025048044,0.042058416,0.09088177,-0.067747585,0.015586868,-0.03810882,-0.017979544,-0.019710928,-0.00092103647,-0.04593215,0.007832137,0.10831862,0.013586088,-0.015530031,0.12339997,-0.03552488,0.050018437,0.026038766,0.08034003,-0.036740907,-0.043579668,-0.09337951,0.0020588485,-0.04422274,-0.06589655,0.04238802,-0.052351292,-0.018658618,0.011970731,0.035307862,-0.0426017,-0.09109458,-0.039425224,0.0054798257,0.012437135,0.017980462,0.021600118,0.006393709,0.0025850695,0.0055243163,-0.02066281,0.009549733,-0.06876386,0.10744122,0.08174511,-0.10219211,-0.11499438,0.018732509,0.038828764,-0.102328606,0.038842183,0.028090691,-0.014102847,0.058502007,-0.08613016,-1.5330078e-33,-0.021902721,-0.013653513,-0.015965886,-0.042874165,-0.009112109,-0.023516389,-0.03611136,0.010012717,-0.022344714,-0.11424238,-0.033363473,-0.02075328,0.029690145,0.12230405,0.0078008687,-0.016580528,-0.010826961,-0.044442102,0.0120416675,0.04278303,0.090522334,-0.038793746,-0.009751982,0.031064361,0.0065845144,0.07547814,-0.019059513,0.06153577,0.054888148,-0.0010599383,0.01905941,-0.040092684,-0.07051992,0.02693752,0.055954732,-0.016358202,0.006381185,-0.0029205554,0.03248583,0.076332435,-0.0033680918,0.017742626,-0.010536236,-0.043838736,0.08885045,-0.063288555,-0.062302433,0.05134088,0.072752506,0.037168972,0.060766,-0.064001836,0.06287882,-0.041335363,-0.0001455559,-0.0031635175,-0.05057313,-0.014982734,-0.0080728745,-0.009183727,-0.025771977,-0.016417077,-0.044565417,0.07928468,-0.0041708606,0.017250637,-0.037711043,-0.0841242,-0.05074367,0.059250437,-0.05485076,-0.00937897,-0.025588641,0.008318034,-0.017261712,-0.04107548,-0.10634862,0.015137487,0.063022465,0.018176205,-0.028665785,-0.055360835,0.009885602,0.08256868,-0.06673067,-0.09591936,-0.020649388,-0.0047282674,-0.04494159,-0.0052803205,0.091248065,-0.073507324,-0.068074234,0.0549763,0.029956948,-2.3348912e-33,0.10223538,-0.041503485,0.017540356,-0.033694312,-0.01874059,0.12545425,0.015005599,0.016763242,0.053141378,-0.011361449,0.033906672,0.012355272,-0.05288797,-0.03936352,-0.0052497075,-0.025298653,0.04937902,0.009524383,-0.08606077,0.033738974,-0.016208865,0.041997783,0.0644865,-0.023471804,0.024291635,0.047064267,-0.02336596,0.033471905,-0.03501278,-0.012842158,-0.062347293,-0.04952423,-0.06654083,-0.06578487,-0.025094524,0.08640537,0.0030748588,-0.02018726,-0.055710103,-0.01390222,0.07974403,0.012730347,-0.026858635,0.038239587,0.013458808,0.0585556,-0.082126044,0.08026373,0.008533541,-0.06624335,0.053962793,0.03787133,0.08099624,0.012777615,0.010030948,0.023256281,0.008148019,0.013866933,-0.03416048,0.024130903,-0.05093658,-0.07534671,-0.010040925,0.028700946,0.01091546,0.055181794,-0.01029347,0.05353813,0.06976522,-0.08469491,0.054378968,0.065732166,-0.045499086,-0.056187604,-0.06876343,0.003678031,-0.12557203,-0.116503865,0.04260842,-0.006189486,-0.0089551965,-0.026517367,-0.026050832,-0.06346939,-0.048343077,-0.019101301,-0.043562073,0.036655802,0.029013772,0.023131704,0.00079152756,-0.037714418,-0.044757232,0.01750111,0.0074009346,-2.975688e-08,0.025829878,-0.10407248,0.07429314,-0.029663846,0.050296135,0.013442878,0.015262839,0.0029486034,0.0317055,0.0423795,0.008326146,0.065091655,0.025178187,0.058334675,0.06326836,-0.007999886,-0.008277637,0.030525712,-0.02549481,-0.0311171,-0.08889432,-0.048090626,-0.09749184,0.03895595,0.063384525,-0.062099673,0.033322785,-0.022224672,-0.063595235,0.009259945,-0.0077011627,-0.0038778996,-0.01556053,-0.0033873052,-0.10200651,-0.0034235658,-0.005479012,-0.043666188,-0.031189423,5.254489e-05,0.05441646,0.05790575,-0.10618041,-0.018531999,-0.0015754369,0.03476087,0.042118933,-0.042397387,-0.04582454,-0.019046541,0.057797406,-0.018819435,-0.010463007,-0.029785767,-0.12709296,-0.03125037,0.024221601,-0.0963561,0.042334568,-0.064978965,-0.021584215,0.042894382,0.20300257,0.078617916 +2.7.2.16,"The enzyme, found in a number of methanogenic archaeal genera, is involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. Activity is stimulated by potassium ions.",384,1.0,0.010597432,-0.015976472,-0.07110747,-0.013879475,0.011743002,0.0025968174,-0.03601938,-0.041297134,0.08090191,0.042503584,-0.044170644,-0.09633867,-0.0032566637,-0.040070184,-0.070415415,0.010955376,-0.047234215,-0.002084205,0.026984531,-0.013176595,0.12184773,0.038638342,-0.0016097835,-0.00022551467,0.030696893,-0.0029051974,0.029192207,-0.023390478,-0.055666104,0.03010077,-0.046956584,-0.007504742,0.13903786,-0.048971333,0.06877309,0.14470176,-0.07373964,-0.010204309,0.0016815086,0.009898654,0.059313066,-0.016972912,0.0752624,-0.021775402,-0.019581117,-0.004892269,0.028193649,-0.031642478,0.03512743,-0.039849225,-0.050042294,-0.07549622,-0.036010895,0.07935461,0.036943227,0.08322165,-0.048714522,0.039024886,-0.002963246,-0.016612014,0.076593615,0.033448268,-0.0063804756,0.03455063,0.03074309,-0.079288855,0.047815558,-0.056291096,0.09762226,-0.0798717,-0.031347293,-0.034810934,0.033802934,-0.076556206,-0.019536808,0.0155856395,0.02819804,-0.06827214,0.035868157,-0.10733984,0.052032236,-0.045559324,0.011927929,-0.019906292,-0.0052559427,0.029826177,0.037234552,-0.029005628,0.048465237,-0.0007839311,0.018696424,-0.033981856,0.073097676,-0.09547834,-0.066865064,0.019667264,0.037063062,0.0054153516,0.0546997,-0.011363127,0.018586269,0.09997991,-0.04523415,-0.072809234,-0.0688358,-0.011697398,-0.029027414,0.05893218,0.0027688502,0.07007286,0.021310285,-0.008161791,0.06624912,0.043229155,0.0182127,0.11434005,-0.0015299491,-0.1193033,-0.020118803,0.053761292,-0.030461824,-0.036632117,0.016505675,0.075400226,-0.02871698,0.10634672,-0.082568064,1.0305817e-33,0.08957284,0.04346209,0.016443146,-0.026828142,0.017116379,-0.05700755,-0.07354077,-0.05456317,-0.033736996,-0.055643916,-0.025047438,-0.044342674,0.09110804,-0.009636018,-0.0070700636,0.0006593004,-0.04963498,-0.0038424032,0.07870985,0.052867584,-0.054426454,0.04036438,-0.052917108,0.0063706026,0.028118448,0.046398837,0.010188097,-0.02247792,0.043780323,0.010014223,0.044040076,-0.06926956,-0.14540082,0.027290143,0.07396666,-0.015144987,-0.042957705,-0.018931907,-0.063737705,0.07110269,0.018185934,-0.0040092976,0.03570698,-0.00628944,0.082896166,0.019441864,-0.06847403,0.14903112,0.07971333,0.050372407,0.017564382,0.013479587,0.1299457,-0.008159856,-0.07994211,0.042926893,-0.0051429183,-0.046122655,0.055056818,0.03649883,-0.045661405,0.04854979,-6.4165484e-05,0.07693773,-0.008233654,0.014347888,-0.054664224,-0.042179737,0.043020956,0.09754041,-0.10168007,-0.009293204,0.017079234,0.04603916,0.01906018,-0.018215666,-0.04809199,-0.06293963,-0.05397595,0.029645389,0.04288455,-0.07223393,0.0442882,-0.020424193,-0.0490807,-0.010792904,-0.03897026,-0.04001748,-0.01737702,0.08843169,-0.010530672,-0.034697186,-0.05826941,0.101556875,-0.040889215,-2.2314362e-33,0.08277935,-0.07521005,0.023450365,-0.04232357,-0.06788084,0.06367957,-0.050002657,-0.04868965,-0.022379875,-0.046364516,0.100032285,-0.00016646192,0.09946648,-0.04349632,0.05585918,-0.0017232429,0.021905297,0.08775626,0.02177177,0.03717826,0.06633706,0.018562784,-0.042442642,-0.025429474,0.038157456,0.0018102711,0.005956912,0.058111686,0.011909685,0.04070687,-0.013291687,-0.011810525,-0.07318173,-0.088365,-0.096688375,0.031323228,-0.062253978,-0.045438036,0.047954984,0.036333278,0.00040029376,0.04962387,0.004310069,0.07803307,0.027006457,0.012985974,-0.014591466,0.037641138,0.07998318,-0.04394089,0.028158618,-0.105518036,-0.018362192,0.00069715,0.036283147,0.046156496,-0.047367077,0.077269696,-0.022196382,-0.048883427,-0.054906927,-0.06724731,0.09366677,-0.038773987,0.028258227,0.059323005,-0.030631848,0.011697074,-0.009666707,0.013977065,0.056272533,-0.002155323,0.033406124,0.03932908,-0.013403542,-0.018250031,-0.04458972,-0.008043725,0.013900958,-0.039507493,-0.03751407,0.073496625,0.06074293,-0.030191198,-0.015344816,-0.078392,0.0585654,0.05414933,-0.0498424,0.0074746404,-0.034794264,-0.05403993,-0.04941969,0.006558062,0.043528643,-3.2405413e-08,0.06751086,-0.04969808,0.035620548,-0.04800129,0.011324053,0.040645,0.050893337,0.0041295863,0.0095575545,-0.06067364,-0.01830495,0.0674586,0.064850315,0.028043905,0.03276675,0.04084918,-0.040457092,-0.0008332254,-0.08573168,-0.034271233,-0.023479449,-0.08338635,-0.06430194,0.023081567,-0.011047916,-0.007833213,0.0020389382,3.0220392e-05,-0.035759892,-0.03402739,-0.08656539,-0.011825879,-0.002943056,-0.063347176,-0.06885522,0.028359551,-0.06483565,-0.04962964,-0.037740618,-0.040759474,0.016557068,-0.04237671,-0.025749309,0.034634043,-0.052324064,-0.04142454,-0.045348268,0.04757267,-0.017079767,0.040107008,0.024403889,-0.02468638,0.01808908,-0.056364007,-0.07335791,-0.07585185,0.038485933,-0.08842206,-0.02789187,0.014297406,0.03345434,-0.0059588477,0.09507261,-0.07015355 +3.1.3.107,"This bacterial enzyme activates the antibiotic amicoumacin A by removing a phosphate group that is added by EC 2.7.1.230, amicoumacin kinase.",384,1.0000001,-0.10922727,-0.02748228,-0.038497593,-0.028350329,0.04851381,-0.032792583,-0.044559136,0.06533865,0.07545156,0.040339723,0.030830756,-0.030631775,0.053378113,0.04534034,-0.017614381,0.04176744,-0.07587462,0.039912805,0.025230706,-0.049644947,0.01618044,0.013364213,0.000850831,0.03555688,0.01428417,0.04631371,0.041956253,0.12757759,-0.016948128,-0.06628342,0.064128,-0.016840452,0.09767593,-0.08018928,0.030399932,0.018719766,-0.052025516,-0.07422603,0.075179726,-0.015107469,-0.002130537,-0.009717289,0.010496132,-0.065809235,-0.0048996294,0.001385061,-0.03441018,0.050812673,0.11721653,0.005954852,-0.045212794,0.025705017,-0.08273052,0.069168314,0.08531242,0.010838224,-0.11116489,-0.0090268515,-0.002939322,0.011022365,0.032801557,-0.039413974,0.061337125,0.060500797,-0.10053245,-0.055099405,0.025305135,-0.09593011,-0.0009321327,0.0017573903,-0.107277945,-0.07092248,0.086266935,0.05255913,0.09171348,-0.015337144,-0.031847883,-0.034344174,-0.021566583,-0.0076689,0.018523065,-0.039586164,-0.014549204,0.080587365,-0.016256686,-0.050045047,0.099238336,-0.019840777,0.04244138,0.058147214,0.106239006,-0.03303839,0.01698111,-0.074601665,-0.0027092013,-0.018157616,-0.07060071,0.07192003,-0.055027243,-0.015781002,-0.0153441345,0.06198656,-0.05574628,-0.09501816,-0.011812171,-0.018682502,0.004929682,0.06815545,0.018757343,-0.022452196,-0.006919593,-0.045819007,-0.055401407,-0.03332114,-0.06658855,0.13208272,0.07400436,-0.07056942,-0.08701201,0.036666833,0.06138048,-0.1199896,-0.002201627,0.028022459,-0.009849819,0.03100506,-0.09849261,-1.596972e-33,-0.023776608,0.025392044,0.014552795,-0.0487032,-0.008162145,-0.03125313,-0.05021285,0.00398731,-0.052646376,-0.12283321,-0.031105287,-0.042685118,0.061033916,0.11357933,-0.061175417,-0.06528515,-0.041781947,-0.022747353,-0.004937656,0.0601411,0.14312127,-0.024951247,-0.010358462,0.018102584,0.024687417,0.06014417,-0.025829356,0.042840105,0.07100472,0.016356373,-0.013457959,-0.039663278,-0.048883382,0.022337288,0.049454067,-0.0285516,0.002533715,0.0053327056,0.08240049,0.093990825,-0.019915313,0.019026196,-0.050624777,-0.0061990884,0.056776926,-0.048813917,-0.039672688,0.08661343,0.09328403,0.045291767,0.05573533,-0.08854305,0.04388895,-0.04321571,0.008084058,0.008106602,-0.038163774,0.010339654,0.018121187,-0.05553353,-0.002772313,-0.0065339697,-0.04612496,0.054631237,0.032154825,-0.008224474,-0.032165036,-0.08020742,-0.01650905,0.047524642,-0.036204383,0.02696736,0.03475436,0.028651766,-0.023758871,0.001916034,-0.05616956,0.025174318,0.0364186,0.059446402,-0.025893038,-0.054007027,0.00875208,0.037789617,-0.047179066,-0.080655135,-0.040900458,0.0067984485,-0.02574411,-0.0014666823,0.06360385,-0.09261815,-0.08170434,0.042535186,-0.015524338,-8.986781e-34,0.118919306,0.00569014,0.07755972,-0.01993313,-0.05760197,0.09172978,0.07390383,0.014041206,0.06944329,0.015150323,0.075437576,0.006842661,-0.0032962789,-0.043502938,-0.014858924,-0.04550623,0.019676926,0.016277768,-0.06172338,0.030120278,0.0034383626,0.0043076384,0.07722258,0.019518934,0.031699017,0.054683592,0.0037463442,0.03246023,-0.026265217,0.019747349,-0.083778456,-0.041117698,-0.03915525,-0.031262554,-0.04019617,0.044447552,-0.027860638,-0.03172586,-0.06898431,-0.08438536,0.060258586,-0.0066549364,-0.026274126,0.043655865,-0.00128003,0.02078586,0.028678605,0.11131816,0.009499461,-0.111620285,-0.027947698,0.07256925,0.038822148,0.024436234,-0.024386061,0.020086832,0.020661624,0.034858156,0.019174038,-0.00048731308,-0.031533815,-0.046515856,0.020834535,0.0030314685,0.051292844,0.03267361,-0.003384802,0.015711887,0.03931096,-0.06662137,0.008156182,0.00064689375,-0.025029216,-0.06631439,-0.021765739,0.0071866103,-0.10714623,-0.10663325,0.0040531405,0.027129399,-0.033782665,-0.037518576,-0.06637155,-0.029913757,-0.044540115,0.047930047,-0.028242033,0.05761165,-0.0074125277,0.0065550995,-0.0031038164,-0.0039159064,-0.028533205,0.039567377,-0.010535229,-2.6995474e-08,0.05269234,-0.10603775,0.06358899,-0.01194228,0.06868638,0.008029295,-0.043226734,0.050376713,0.041491903,0.003557755,0.027445873,0.07689163,0.01665221,0.014110378,0.058308244,0.012345586,-0.00722995,0.04041158,0.008003914,-0.046461288,-0.028851215,-0.09749923,-0.07274711,0.025034571,0.07194356,-0.051713243,-0.0053548887,0.022595674,-0.08839604,-0.023418143,0.014440324,-0.055769913,-0.041170564,0.013601227,-0.07427606,0.0017627673,-0.06813914,-0.042395137,-0.0010236097,0.0021731895,0.07292185,0.046432283,-0.0819916,-0.01472443,-0.015001983,0.06406819,0.030101797,-0.029350797,-0.038491923,-0.03937801,0.050272044,-0.03391299,-0.03322833,-0.04878811,-0.101278745,0.020995334,0.015024923,-0.07497579,0.042796735,-0.04595706,-0.0065609557,0.018930662,0.12692298,0.05193969 +3.6.1.69,"The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 3.6.1.55, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 3.6.1.58, 8-oxo-dGDP phosphatase.",384,1.0,-0.11108556,-0.012995055,0.013852851,-0.058495536,0.085618675,-0.03205848,-0.010109448,0.115581684,-0.014139232,-0.018898584,-0.07627093,0.045738433,-0.007107038,0.019167712,-0.052712176,0.081629775,-0.031026792,-0.012881473,0.015076056,-0.051421218,0.06927611,0.07801345,-0.0022282272,0.016436579,0.08948536,-0.003838213,0.11793706,0.07625382,-0.039165683,-0.08650988,-0.046707537,-0.017003048,0.040044,-0.10617846,0.06823782,0.117117286,1.1803419e-05,-0.10215377,0.022633092,0.0046854583,0.08437346,0.011383495,-0.008248006,-0.03974956,0.041632764,0.05200451,-0.016730748,0.11858351,0.032764483,-0.0061963787,-0.03227622,-0.06653797,-0.02613434,0.037962314,0.03457331,-0.026187897,-0.062408283,-0.003740094,0.0024743958,0.010606428,-0.018564867,-0.003093432,0.061246887,0.04264867,0.108652,-0.024485542,0.010734191,-0.067460485,-0.012610662,-0.006723401,-0.12923783,-0.05573489,-0.026707416,0.08992655,-0.054084823,-0.010337765,0.016371233,-0.061675444,0.07022739,0.009327006,-0.024223808,-0.029595263,-0.0040440164,0.025439598,0.030999823,-0.012225119,0.04140027,-0.016974619,0.03551583,0.051708914,-0.02711767,-0.024459874,0.018483728,-0.008350004,-0.05696158,0.035065588,0.056847364,0.04725737,-0.043872662,-0.01896252,0.05218206,0.061394587,-0.04129394,-0.039004568,-0.027616128,-0.00040076376,-0.013556753,0.06688504,0.02542173,0.004051149,-0.014464532,0.019642737,-0.0026770574,-0.03058696,-0.065670155,0.058512643,0.022111904,-0.05257048,-0.120067075,-0.013133387,-0.017778222,-0.08589449,0.036359783,0.07068041,-0.076974384,0.0524307,-0.05560247,2.4497618e-33,0.038994577,-0.046058927,-0.02919584,-0.051012486,0.008204388,-0.021656599,-0.08037416,0.020147007,-0.06914,0.012804256,-0.08130045,-0.067479216,0.061135393,0.024854207,-0.050655626,0.024288373,0.0009231652,0.091875024,0.0604253,0.04787946,0.05022776,0.0038241337,-0.0326049,0.07160263,0.026950281,0.09965867,-0.070572846,0.0010413566,0.06897266,-0.014084181,0.0013592015,-0.08061345,-0.10518049,-0.017031435,-0.0529405,-0.088724844,-0.08805265,-0.11163321,0.05097968,0.05650028,0.014190988,0.0070632035,0.0057525295,-0.03813327,0.05802562,-0.011467806,-0.010698194,0.030643491,0.025818428,-0.0021585252,0.027706172,-0.027893154,0.083258994,-0.050500438,-0.0016629646,-0.02943989,-0.059921943,0.046994835,0.09314547,0.045951195,0.033614844,0.082442336,-0.032091,0.059473246,-0.017941538,-0.0054131513,-0.06352911,-0.0054302216,0.07397575,0.057656728,-2.6183907e-05,0.016238412,0.01419069,0.01940871,0.025338108,-0.07078422,-0.029604383,-0.012833761,0.02930424,0.030027444,0.0571183,0.0001005179,-0.034998193,-0.06353408,0.017056463,-0.0073250122,0.006903783,-0.061656207,-0.034739643,0.019043433,0.046708893,-0.050684836,-0.08551006,-0.015867222,-0.0025186648,-2.3901521e-33,0.077962354,-0.07774722,0.023258079,-0.10889503,0.003780147,-0.057022724,0.05010075,-0.036396325,0.06782348,-0.037706684,0.045909945,-0.030887768,0.011404275,-0.06328727,-0.049142633,-0.015865581,-0.021580486,0.023467949,-0.05222545,-0.02817493,0.011291954,0.0698893,0.038249318,0.034210436,-0.0111452,-0.0071102995,-0.07336746,0.022894043,0.07858908,0.093242325,-0.023398817,0.12363662,-0.03221518,-0.0040614475,-0.042216994,0.03144209,-0.09028874,0.0033701204,0.09998097,0.026697537,0.040804036,0.06930505,0.0018971368,-0.023431888,0.015023097,0.09842968,-0.056445573,0.044008944,-0.010857525,-0.012617723,0.010786159,0.008134884,0.009722986,0.034123857,0.04311687,-0.024571253,0.0072414465,-0.004098381,0.005128902,-0.03647644,-0.023204317,-0.053855218,0.017895149,0.010396593,0.018594885,0.17913346,0.023876702,0.046632037,0.016436378,-0.011773841,0.053484578,-0.042454883,0.04438344,-0.026052158,0.009003,-0.024315847,-0.046173826,0.07600384,0.019008065,-0.033215925,-0.038359948,0.011884586,-0.01244378,-0.06032496,-0.028515618,-0.037727933,-0.032689724,0.099493414,-0.0023109224,0.051471222,-0.04268536,-0.016714048,-0.06848402,0.027773686,0.05328612,-3.9642007e-08,0.04406763,-0.085140735,0.10058477,-0.032766856,0.0532424,0.022002928,-0.0007080922,0.058432966,0.11096434,-0.007900474,0.068656996,0.035689995,-0.014027592,-0.09520357,0.102025874,-0.011652324,-0.020798763,0.03374425,-0.04258956,-0.015270408,0.00302002,-0.0035502308,-0.041520935,0.07508667,0.03394544,0.003311781,0.008346512,-0.017576713,-0.006091202,-0.048433013,-0.009956729,0.07063271,-0.00516897,-0.057113077,-0.06292006,0.005386849,-0.042589482,0.03024035,-0.05283941,0.03925012,-0.012016034,-0.08510976,-0.0684432,0.0145316,-0.03700094,0.025466904,-0.009456397,0.0070536896,-0.02345229,-0.02693407,0.035535034,-0.04907266,0.0071509858,-0.020398948,-0.07532098,0.020176236,-0.0131198205,-0.04854697,-0.066916354,-0.054754283,0.028080853,0.023045605,0.19916181,-0.06132813 +3.6.1.70,"Aprataxin is a DNA-binding protein that catalyses (among other activities) the 5' decapping of Gpp-DNA (formed by homologs of RtcB3 from the bacterium Myxococcus xanthus). The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and eventual release. The enzyme forms a 5'-phospho terminus that can be efficiently joined by ""classical"" ligases. The enzyme also possesses the activitiy of EC 3.6.1.71, adenosine-5'-diphospho-5'-[DNA] diphosphatase and EC 3.6.1.72, DNA-3'-diphospho-5'-guanosine diphosphatase. ",384,0.99999994,-0.06847297,-0.098549545,-0.09058364,-0.042958006,0.035973184,-0.03199663,0.032568924,0.03442625,-0.007671047,-0.023828594,0.09810767,-0.05283376,-0.030642757,0.06359192,-0.08362713,0.04839407,-0.03863568,-0.033420067,0.027380824,0.0050163856,0.003396229,0.05298991,-0.0074577695,-0.03538752,0.044950016,-0.000834766,0.11247661,0.0075214226,0.007090647,-0.106697835,-0.066205755,-0.06826133,0.012937703,-0.029221293,0.038362626,0.1430643,-0.02251611,-0.035270695,0.032189127,0.00026970726,0.060362853,0.023285795,0.0059237136,0.06351158,0.02634344,0.0135667855,-0.036578495,0.073409565,0.012329172,-0.009055267,-0.06312668,-0.056920137,0.009729503,0.069022484,0.008426001,-0.0181987,-0.10123555,-0.06941096,-0.016235588,0.031244447,0.03688313,-0.016339393,-0.005119861,-0.0617803,0.008669025,-0.049330994,0.06300162,-0.035195142,0.008784349,-0.007589814,-0.011403983,-0.022977669,-0.034725662,0.047864184,0.0049857832,0.033607528,-0.04676167,-0.05033218,0.042288445,0.051432237,-0.056161463,0.052085984,0.04980091,0.06262966,0.059931703,-0.006035441,0.033580363,0.02363256,0.005899981,0.0621645,0.032088213,-0.020094298,0.046992693,-0.07698634,-0.024258701,-0.00107336,-0.021181475,0.0011298709,0.029705964,-0.056034654,0.026030794,0.016681325,-0.13544261,-0.01726332,-0.043130342,0.0033625115,-0.04450114,0.083767235,-0.0032921163,0.031560518,-0.0931702,0.019173352,-0.028720208,-0.06481932,-0.0718901,0.05705793,0.018085463,-0.054676123,-0.044655554,0.051433716,-0.028793875,0.006905389,-0.057025097,0.07993193,-0.014856806,-0.056167714,-0.094171844,3.3326e-33,-0.022700753,0.016123392,-0.0446242,-0.010087189,0.07770978,0.0017268409,-0.09924271,-0.04373928,-0.09431969,0.0019596552,-0.04706263,-0.008394705,0.012440224,-0.0020608203,-0.02865458,-0.012288911,-0.036466565,0.018519176,0.058151457,0.026080348,0.02255458,0.022706252,0.002917871,-0.016776655,0.013916826,0.075392365,-0.044673357,0.006065093,0.083254315,-0.020932445,-0.008231274,-0.07706455,-0.09728873,0.027851215,0.006864251,-0.027757935,0.04243778,-0.078005284,-0.027899943,0.10396129,-0.03876686,0.051025655,-0.018885883,-0.05034096,0.08055607,-0.094850406,-0.057638727,0.06559185,0.02892392,-0.010239175,0.086032,-0.08319338,0.10996001,0.00062951975,-0.076830365,0.0021804762,-0.099979535,0.007701318,0.0171975,0.047571253,0.022304831,0.01012955,-0.02059739,0.034451943,-0.06304643,0.050407626,-0.065660164,-0.025239905,0.064877704,0.12988761,-0.040075723,-0.043723293,0.027160402,0.008168501,0.011584179,-0.027469473,-0.118339956,-0.03627255,-0.012479932,0.040669035,-0.005469976,-0.023510411,0.06152135,0.04171758,-0.056471262,-0.034791708,-0.014862539,-0.01413266,0.0049419235,0.0103089055,0.091644816,-0.014606151,-0.026769172,0.013297602,0.024078444,-3.8060575e-33,0.17463951,-0.0968428,0.052517038,-0.07721165,-0.027778506,0.004322114,0.02132582,0.006504072,0.03966231,-0.044975407,0.06674755,-0.014338503,-0.03199829,0.021510532,-0.014239441,0.034068048,-0.0010714965,0.10172314,-0.015041314,-0.068155535,-0.069152586,0.03093188,0.025995556,0.010502409,-0.00089218054,0.010028466,-0.023053024,0.07112164,0.029465854,0.04015553,-0.09515042,-0.010288503,-0.04953229,-0.030215226,-0.0045273565,0.032449715,-0.03436032,0.04719152,0.058527317,0.02216991,0.04428868,0.06277991,0.019678816,0.070774116,-0.03820373,0.13401672,-0.0006479976,0.042352434,-0.03974431,-0.0828088,0.043181084,0.004074137,0.02557051,0.028629012,-0.0029260335,0.04105769,0.024236683,-0.028515315,0.039144244,0.034413654,0.01915099,-0.10219017,0.0018573161,-0.0009882397,0.08760905,0.0381522,0.001980662,0.06461595,0.03781392,0.020105176,0.018017383,0.028291855,0.021595601,0.02544215,-0.008953732,-0.00019706567,-0.023652636,0.003317164,0.10958056,-0.004665685,0.024593277,0.004633426,-0.06845098,-0.028215496,0.032203976,-0.020380832,0.070341825,0.15552236,0.01776838,0.040369432,-0.0019614582,0.017685669,0.005968098,0.014433661,0.04239946,-5.1441287e-08,0.10750008,-0.07847949,-0.0139108,-0.07701194,0.031985678,0.05944989,-0.032679155,0.033504,0.09701,0.00995726,0.05002076,0.0491497,-0.008552799,-0.036256008,0.054929934,-0.018947553,-0.0005442762,0.023636883,0.001309886,-0.029630972,-0.08286525,0.043203525,-0.12534258,-0.0038544529,-0.049478605,-0.032535017,0.05535672,0.06942257,-0.04953282,0.02367907,-0.042415295,0.018594148,-0.018118523,-0.05735193,-0.09750751,0.059886318,-0.03649517,-0.04985042,-0.0076915487,-0.00831866,0.04969668,-0.0026573215,-0.082699895,-0.009598697,-0.009644728,0.031854358,0.014027312,-0.034449402,0.012761991,0.024559796,0.09191565,-0.009962897,0.0333304,-0.054762915,-0.102569275,-0.010169062,-0.04885375,-0.07874591,-0.07064731,-0.061492674,-0.003848571,0.026644927,0.14831604,-0.053530958 +3.6.1.71,"Aprataxin is a DNA-binding protein involved in different types of DNA break repair. The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus. It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, ribonuclease H, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction. Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined. The enzyme also possesses the activities of EC 3.6.1.70, guanosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.6.1.72, DNA-3'-diphospho-5'-guanosine diphosphatase.",384,1.0,-0.06440375,-0.09488234,-0.024617521,-0.052584976,0.05301806,-0.004329302,-0.005729075,0.028891198,-0.0016012855,-0.003053636,0.08283819,-0.0019191977,-0.09214583,0.041164573,-0.061143197,0.08540282,-0.07617484,-0.015005607,-0.027797258,0.021497702,0.00696959,0.082884684,-0.008415143,-0.016599452,0.010235888,-0.0032045522,0.06784997,0.024962667,-0.021614363,-0.14850713,-0.03931533,-0.07537306,-0.020723691,0.0026711088,0.022030205,0.1292645,-0.008332998,-0.025534676,0.0030829285,0.017643081,0.03993619,0.040537424,-0.015443546,0.038065422,0.04899192,0.0038064625,-0.033635803,0.0483394,0.050020352,0.0052499957,-0.013039129,-0.06598655,0.01710131,0.06938756,0.056529433,0.01573326,-0.06723063,-0.021457803,-0.013048926,0.043754727,0.05424389,0.00916405,-0.031651415,-0.06649521,0.088397905,-0.073711134,0.08372698,-0.068238646,-0.008529011,-0.031179434,-0.011417498,-0.08487678,-0.018057516,0.054628447,0.041062348,0.038890272,-0.044589598,-0.051199567,0.03515858,0.025816552,-0.0847378,0.04148683,0.052230068,0.05927685,0.061460257,0.009630325,0.0022459195,0.015952552,0.023929236,0.022370996,0.00598565,-0.016803531,0.049925353,-0.052486394,-0.010223898,0.05577565,-0.037084065,0.003427918,0.011321881,-0.037069693,0.033209976,0.056573503,-0.13769759,-0.061113097,-0.034133717,-0.030270644,-0.02615136,0.069770314,0.020437272,0.020726753,-0.049406044,-0.002133713,-0.02017592,-0.025554258,-0.060806632,0.055027615,-0.017053785,-0.04367531,0.04903209,0.03136764,-0.021698114,0.016797759,0.0009732223,0.08052642,0.036310934,-0.017363973,-0.06406437,1.6021529e-33,-0.009361222,-0.0043401453,-0.032343302,0.03747694,0.053191613,0.00076790666,-0.10645678,-0.048748247,-0.07971031,-0.00845339,-0.03412508,-0.01915101,0.020879842,-0.046532266,-0.009754102,-0.039545074,-0.060832687,-0.00061230815,-0.027495205,0.019184044,-0.009817953,0.035553887,0.016965887,0.03161644,0.020065833,0.026183838,-0.028479485,0.061369136,0.09631436,-0.011780216,-0.03848161,-0.026633395,-0.057590894,0.049062137,-0.02313017,-0.04019959,0.026753183,-0.0585465,-0.0344017,0.11610178,-0.063962705,0.036121655,-0.040913064,-0.047176942,0.098201424,-0.13920265,-0.030965643,0.06514506,0.016465263,-0.03952054,0.07123042,-0.092874534,0.119811036,-0.018390648,-0.078179665,0.038407274,-0.082547724,-0.03068678,0.04894168,0.043197308,0.012516754,-0.000636843,-0.010755193,0.03239116,-0.022362795,0.036088675,-0.038426206,-0.034678005,0.06941521,0.09923446,-0.028433975,-0.02616032,0.04789815,0.014372866,-0.04388068,-0.018803818,-0.11804404,-0.01678837,-0.026904354,0.06600672,0.0034967228,-0.05463716,0.061476313,0.015387361,-0.06339325,-0.030643085,-0.004025009,-0.058324847,0.039289244,-0.008735544,0.102152295,-0.018778728,-0.043360528,-0.0629715,0.064369686,-1.9883634e-33,0.16041404,-0.1106667,0.062018145,-0.04802284,-0.013600176,-0.0063341903,-0.014136032,0.024007553,0.032843523,-0.074689396,0.05392584,-0.02267033,-0.029884966,-0.007745261,-0.02689806,0.037643593,-0.043780684,0.08331898,0.0013324564,0.0011742047,-0.027234674,0.033176374,-0.0020734207,0.07400736,0.018275555,0.011598442,-0.030462015,0.034628358,0.046762627,0.011098499,-0.050903905,-0.029866865,-0.024046963,0.043622434,0.004838727,0.04575904,-0.006132569,0.020647459,0.014534546,-0.0033231683,0.055958334,0.047831252,-0.03356053,0.05457808,-0.012495698,0.08772156,-0.017495899,0.06627041,-0.039624713,-0.09598408,0.08115135,-0.026162632,0.06498824,0.049709246,0.0051035276,0.012398424,0.030645916,-0.026086396,0.018178245,0.034512307,-0.01625885,-0.09055666,0.02224962,0.023501819,0.09902131,-0.00086541765,-0.027597845,0.0729314,0.033209126,0.030624472,0.030477343,0.06907339,0.045870945,-0.011269188,-0.008518779,0.0058295177,-0.05863727,-0.02895004,0.06104834,-0.011791766,-0.0071473955,-0.0019444998,-0.076055594,-0.0020800873,0.05769087,-0.008126965,0.03876153,0.19434513,-0.007257628,-0.018667521,-0.021508537,-0.012789335,0.01638373,0.017538507,0.009376275,-5.2239177e-08,0.11782156,-0.04581593,-0.040111046,-0.08121069,0.037648007,0.018224558,0.006811522,0.09298833,0.07366004,0.030822065,0.0032724992,0.117404215,-0.01943019,-0.010041461,0.0389369,-0.010655337,0.016542403,0.05128344,-0.0021580625,-0.018279904,-0.093736134,0.038591955,-0.117384456,0.006408363,-0.062159345,0.010130135,0.04970505,0.093469016,-0.044283416,-0.033186708,-0.029187825,-0.033312954,0.039326552,-0.055320147,-0.113334686,0.058032494,0.03598547,-0.032991998,-0.022891508,0.023571866,0.034097813,-0.004814226,-0.06279474,-0.030087907,-0.029810546,-0.013959481,0.009626068,0.003354044,-0.037409496,-0.011220471,0.08410006,0.008136458,0.00961973,-0.073990874,-0.13357401,-0.032156967,-0.02007459,-0.065478265,-0.023871744,-0.037955422,0.0020781087,0.0056822747,0.17308484,-0.032954942 +3.6.1.72,"Aprataxin is a DNA-binding protein that catalyses (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8, 3'-phosphate/5'-hydroxy nucleic acid ligase) [1]. The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release. The enzyme also possesses the activity of EC 3.6.1.71, adenosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.6.1.70, guanosine-5'-diphospho-5'-[DNA] diphosphatase.",384,0.99999994,-0.08025154,-0.07272512,-0.06855694,-0.03666626,0.03698479,0.0013596416,0.020797625,0.036266044,0.012206789,-0.045449384,0.10822972,-0.024331104,-0.06141461,0.03142072,-0.06511539,0.056073118,-0.0442506,-0.043423593,0.029818831,-0.026082575,0.00035787481,0.030325824,-0.010103147,-0.012803124,0.051649053,0.015154569,0.10666895,0.03276536,0.0273747,-0.11581368,-0.05283664,-0.053701364,0.010562522,0.012254819,0.023607299,0.13366184,-0.032446377,-0.01629617,0.01092275,0.0135261705,0.061544187,0.037222136,-0.005008354,0.050448515,0.02634852,-0.0027230226,-0.026840106,0.036680263,-0.00034043175,-0.00818736,-0.025202157,-0.09285378,0.010298839,0.043109,0.0021386102,-0.040475104,-0.09183457,-0.030413307,-0.017456265,0.02061376,0.022570351,-0.020166125,-0.026907748,-0.06374679,0.04261856,-0.051720887,0.09193832,-0.023267658,0.0029212753,-0.03435858,0.013501893,-0.03754911,0.011761136,0.045924522,-0.02966633,0.028742906,-0.06968565,-0.052709278,0.06338655,0.044422384,-0.029382318,0.051864207,0.025499765,0.068416215,0.06798226,0.0025872781,-0.005435631,0.049803212,-0.0018572726,0.030055717,0.03567301,-0.019255359,0.030671937,-0.04541011,-0.032974284,0.06388492,-0.05383192,-0.008841565,0.018372362,-0.046585314,0.05930626,0.06989494,-0.14129756,-0.026466113,-0.03263252,0.0133386105,0.0174458,0.061346065,0.0011989059,0.03479205,-0.09197752,0.01858531,-0.016762054,-0.03924992,-0.0916333,0.06385527,0.01586618,-0.017595256,-0.027492953,0.04124603,-0.0157948,0.04195097,-0.02983549,0.07605735,0.02715605,-0.025280738,-0.080599345,1.5425977e-33,0.018804906,-0.0068383124,-0.033165455,0.020588303,0.058897097,0.035124853,-0.0954249,-0.04271757,-0.09344516,0.027243238,-0.049530648,-0.024128882,0.018471703,0.022185873,-0.011033016,-0.018802634,-0.023007255,0.010750635,0.06143937,-0.026641788,0.018490644,0.00876231,-0.016901826,0.009970311,0.0046410123,0.07294468,-0.07221691,0.03611219,0.07228689,-0.020281335,-0.019135531,-0.04871369,-0.08819771,0.04501226,-0.0034029519,-0.026442725,0.028285615,-0.05898331,-0.026885392,0.10904038,-0.0343415,0.025175197,-0.03600181,-0.05827678,0.06560607,-0.11148587,-0.062917896,0.06629395,0.049704906,-0.027468096,0.063686825,-0.07680297,0.109423555,-0.018202964,-0.058860872,0.02133193,-0.080897644,-0.009755697,0.04048017,0.049729172,0.044211503,0.028019045,-0.021491122,-0.0077297953,-0.013559478,0.06568176,-0.087386504,-0.022891447,0.05371888,0.13137175,-0.0064867893,-0.048456088,0.0027198368,0.02754923,-0.0006492182,-0.03093538,-0.12216702,-0.017743133,-0.027816523,0.04792382,-0.009818613,-0.05702233,0.045494255,0.019472614,-0.08184909,0.009371646,-0.01169258,-0.029500803,0.032986924,0.04296755,0.0750808,0.0068420153,-0.04082826,-0.029457323,0.024792004,-1.3715345e-33,0.14150138,-0.06377726,0.005010976,-0.085024185,-0.02252746,-0.004385827,0.024968572,0.0076127686,0.044271167,-0.036537424,0.03924682,-0.03906823,-0.027036708,-0.007216069,-0.01617023,0.08363876,-0.046489555,0.08662535,0.008818775,-0.04303607,-0.0899026,0.020183306,0.038030017,0.059244435,0.019412851,0.014519367,-0.0021295748,0.018044122,0.03945957,0.033713266,-0.10498957,-0.010592309,-0.03343953,-0.021796945,-0.030180251,0.027994674,-0.018727323,0.047143716,0.029379845,0.0034212673,0.027453085,0.06952477,0.020841016,0.08008902,-0.0034921244,0.1253384,0.02911919,0.039738018,-0.05358906,-0.099101,0.033422492,0.0016005427,0.040024243,0.056772392,0.0150606055,0.021026399,-0.010238531,-0.070068024,0.0656685,-0.00012333744,0.026400495,-0.10596945,-0.057885934,-0.008711524,0.07119604,0.04744634,-0.028065696,0.070035644,0.037374027,0.037345942,0.03535944,0.0052993423,0.04902029,-0.0043234266,-0.022079738,0.0088287005,-0.036771618,0.03219815,0.0951668,-0.028657848,0.04009432,0.015277433,-0.09814003,-0.022312494,0.011069214,0.00051164196,0.049449567,0.15997136,0.029418822,0.04128818,-0.038292132,-0.01912571,-0.011116971,0.05286952,0.044838954,-4.886742e-08,0.116246946,-0.101094656,-0.009949113,-0.07513494,0.020042632,0.058885437,0.022274144,0.07473136,0.08463009,0.013997034,0.006157121,0.08739395,-0.005866885,-0.011147676,0.03754955,0.011779197,0.020548867,0.059730347,-0.0043960535,-0.0368629,-0.0518109,0.03661252,-0.13775478,0.024042862,-0.056764096,-0.0047590774,0.038571294,0.077228606,-0.04657156,-0.005216713,-0.03550813,0.017180124,0.015342965,-0.09595673,-0.062075123,0.07627746,0.015270128,-0.05168211,0.0013678834,-0.013314393,0.008128289,-0.007129588,-0.08650444,-0.02539397,-0.047927983,-0.017236726,0.029392637,-0.011398047,0.01274228,0.016095538,0.09935429,-0.03527736,0.031250283,-0.039633654,-0.10999864,-0.04681809,-0.03690698,-0.090762,-0.0719922,-0.093028694,0.0014574225,-0.0018046654,0.16771917,-0.05329253 +4.1.1.119,"This bacterial enzyme, isolated from anoxic, toluene-producing microbial communities, is a glycyl radical enzyme. It needs to be activated by a dedicated activating enzyme (PhdA). The activase catalyses the reductive cleavage of AdoMet, producing a 5'-deoxyadenosyl radical that leads to the production of the glycyl radical in PhdB.",384,1.0,-0.11008043,-0.08694165,-0.13080274,0.03408312,0.03019035,-0.032140873,-0.055498224,0.04937897,0.0061389985,0.02374556,0.04527626,0.010515717,-0.05278749,0.08451565,-0.04596651,0.1232865,-0.064711675,-0.03215354,-0.013576426,-0.05469539,0.0023898918,0.05162635,-0.00915225,-0.033897042,0.0140923895,-0.041835357,0.037978876,-0.03815404,-0.0739357,-0.036434304,0.094827764,0.029010762,0.08855195,-0.016053269,0.060747463,0.13113154,-0.06590228,-0.025875136,0.06904233,-0.009335229,0.02836123,-0.054281246,-0.026133362,-0.041134827,-0.027269876,0.02058004,-0.0100102695,0.042943645,0.065128654,-0.049858507,-0.054930497,0.016782539,-0.04609897,-0.03975397,-0.03642839,0.016404679,0.020814084,-0.0033857406,0.015575657,-0.04698109,0.06801552,-0.014613465,-0.03381711,0.028928913,-0.057366062,-0.041668326,0.08373474,-0.07389696,-0.009789848,-0.05911516,-0.046197105,-0.08391066,-0.013713783,0.052758303,0.029258728,0.0057386006,-0.01628068,-0.037647072,0.061873324,-0.000121623816,0.10250775,-0.025844643,0.036874715,0.08880451,0.05274255,-0.0074366042,0.020847332,0.02160063,0.057966758,0.03321224,-0.021316737,-0.0016376585,-0.011925863,-0.032818623,-0.0764552,-0.026210591,0.03746645,-0.043127023,-0.043749824,-0.0012341475,-0.06611099,0.013788859,-0.012070536,-0.08663853,-0.08934214,-0.0146690905,0.0061767353,0.047349557,0.12422229,-0.0030790896,-0.012889084,0.026993483,0.05742767,-0.084438704,-0.0066930586,0.068358704,0.02444106,-0.05510075,-0.032566987,-0.0068999133,0.049439088,0.010858109,0.028687384,0.032145847,-0.06923703,0.04545876,-0.07732914,2.1955509e-33,0.08702338,0.09068749,0.018636946,-0.003727382,-0.029359115,-0.018259218,-0.07745378,-0.024221353,-0.0029376582,-0.054176167,-0.054963414,-0.0823363,0.040182386,0.031100858,-0.07261057,-0.02367011,0.025016036,-0.047061194,0.061370544,0.043028075,-0.06849466,0.021709766,-0.073558636,0.0063798088,0.066962555,0.029112034,0.037665423,0.050282903,0.048286907,0.013330106,-0.013428275,-0.11341193,-0.13165943,0.006387808,0.03455497,0.024686828,-0.04043077,-0.04261313,0.04519095,0.043302942,-0.0077878293,0.010607438,0.04027182,0.010504525,0.08212239,0.081121385,-0.07054646,0.07589023,0.061129287,0.08894616,0.048821025,-0.05096722,0.073347785,-0.039431166,-0.08174319,0.035797168,-0.011426806,0.02814586,0.08078403,0.067188405,0.019347567,0.037045345,-0.10357666,0.0627105,-0.04789435,0.026531717,-0.033506814,-0.03904562,0.0016986371,0.0312585,-0.049245745,0.08197775,0.13453117,0.037823435,-0.038552895,-0.010336654,0.025727998,0.04342033,0.06960609,-0.022658248,-0.074829325,-0.06436523,-0.0065126815,0.004169834,-0.031125171,0.007962367,-0.06984462,0.025050974,-0.07797016,-0.01268531,0.06681366,-0.10150185,-0.042872958,0.046897385,0.017570386,-3.4142582e-33,0.07335955,-0.056566186,-0.032120667,-0.049470928,0.006548886,0.06525948,0.024539188,0.03544099,-0.01773825,0.026930997,0.06250046,-0.02718403,0.026937097,-0.041750975,0.043518525,0.048839338,0.041344453,0.037340824,-0.08522269,0.017807838,0.04275512,0.04017219,0.011865081,0.0038215583,-0.012106761,0.021228436,-0.019798351,0.05941748,0.038372893,0.049775004,0.018148782,0.04053196,-0.0609835,-0.07533744,-0.0002752384,0.1045241,-0.03680899,-0.015164022,-0.057679083,-0.031486474,0.010355723,0.0002546344,-0.055056263,0.14641961,0.042223528,0.095637575,-0.059968267,0.008229351,0.030651994,-0.08517068,-0.025206381,0.036098048,0.06900564,-0.051471613,-0.023993831,0.042046156,0.07315096,-0.033673525,-0.050504766,-0.022565048,-0.027837241,-0.052462023,0.05490267,0.0023794742,-0.017293777,0.05659624,-0.03921184,0.024643565,-0.022543393,-0.003413623,0.035682153,0.0025652312,-0.026301831,0.02473357,-0.068443574,-0.034488827,-0.04650018,-0.044349656,0.026402222,0.050127525,0.035077058,-0.0129534,0.0024794613,-0.026484596,0.021575686,-0.115318105,0.04471349,0.048313893,0.004712389,0.038389202,-0.052744877,0.028000915,-0.09042606,0.019040063,0.05760376,-3.73307e-08,0.010572177,-0.0669705,0.04005906,-0.0909434,0.01656961,0.042833284,0.053857766,0.03184346,0.020749187,-0.09733941,-0.044980407,0.08612305,-0.030841898,0.04197242,0.03173792,0.06276172,-0.051676642,-0.003344326,-0.018656245,-0.028816575,-0.040897224,-0.025030978,-0.07687157,-0.007659437,-0.02949051,-0.035872735,0.030257674,0.03556262,0.0027632865,-0.02663553,-0.011651525,0.05113987,-0.0924811,0.05005275,-0.13882388,-0.012556739,-0.028488744,-0.02223693,-0.03489168,0.05204224,-0.041867584,0.01522451,-0.067612745,0.051873557,-0.029970473,0.022244822,-0.03131467,-0.022844238,0.032093648,-0.012273496,0.03302169,-0.030880576,-0.0347729,-0.009171751,-0.11530276,0.020699004,-0.0103002945,-0.006743154,-0.038923234,-0.04931482,-0.004108746,0.02102386,0.13366833,0.01263401 +5.5.1.34,"The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. The product is a precursor of (+)-cis,trans-nepetalactone, the primary ingredient responsible for the psychoactive effects catnip has on cats.",384,1.0,0.0030601982,0.024818378,-0.014981371,0.03292262,0.0013831512,0.051622134,-0.018512422,0.05830172,0.040789597,-0.014644405,0.011614957,-0.060945004,-0.023374189,0.07339432,-0.07029274,0.051333845,-0.033457596,0.053344898,0.058291703,-0.00545073,0.009188432,0.007230316,0.030447742,-0.00960766,-0.03216022,0.08044816,-0.07107937,-0.04605098,0.02502833,-0.021554792,-0.065941446,0.02678693,-0.045626752,0.0021970323,-0.03342512,-0.012477472,-0.064670876,-0.04408858,0.011788721,0.07798502,0.035290077,-0.03330845,-0.063326605,0.008268874,-0.022136992,-0.0677173,-0.013170602,-0.026498593,0.03666953,0.005146598,-0.10188101,0.00061089767,0.011970249,0.030621644,-0.04228842,-0.03245662,0.048772655,-0.017706534,-0.0140385935,0.024601229,0.060817678,-0.03794623,-0.0054598167,0.0033168208,0.09671914,-0.006827125,0.003634247,0.013470439,0.021843195,-0.01355196,-0.050124492,-0.055194072,-0.021569932,-0.034334607,-0.020979358,0.0639347,-0.00702023,0.020115202,0.0605502,-0.01944331,0.06602627,0.101300284,0.04515432,0.08135157,0.1223132,0.07196205,0.00016786635,0.0068306625,-0.037283856,0.042053204,-0.016988864,-0.063548826,-0.033609018,-0.010537096,-0.068239726,0.014009739,-0.05610525,-0.013001854,-0.033620927,-0.0062037604,0.00015259624,0.021105386,-0.09802485,-0.023731148,-0.097085215,-0.0007823586,0.019800592,-0.019822715,0.028539548,0.04788043,-0.07056415,-0.07751697,-0.041773558,-0.023505716,0.043355767,0.12702912,0.014580514,0.008615662,0.0318891,-0.07479881,0.03914764,-0.049172983,-0.028878657,0.026883453,-0.033597127,0.024133196,-0.114662215,-4.6450156e-35,0.09284458,0.00892903,-0.06468094,0.043350063,0.08429516,0.050549384,-0.05580076,0.04164391,-0.120838456,-0.064912796,-0.05974691,-0.022896204,0.0045730965,0.010978145,-0.040063985,-0.0664582,0.025450636,-0.06556374,0.08843782,-0.05203822,0.027866352,0.0497148,0.029747732,0.07228693,-0.012574665,-0.014489611,-0.13349941,0.020503711,-0.05754435,-0.030495271,0.031109905,-0.066464946,-0.091572024,0.017653542,-0.042667925,-0.02795769,-0.015660424,-0.06881491,-0.0053829164,0.04850826,-0.021522513,0.061946288,0.03407695,0.019227348,0.036998726,-0.0109802885,-0.10171272,0.07098713,0.0563234,0.07938827,0.073628,-0.028591705,0.011617871,-0.08222659,-0.10770929,0.04535132,-0.051795207,-0.051973738,-0.0001694384,0.07328136,-0.039281763,-0.015159682,0.020459872,0.00048186033,0.019699376,0.015569523,-0.016746012,-0.067618676,0.096827865,0.07041705,-0.067606516,0.07623611,0.042699054,0.0061050877,0.043090843,-0.052273776,-0.05057386,0.020411046,-0.03515631,0.07156849,0.004302233,-0.020166423,0.015588932,-0.004786193,-0.05561151,0.01967949,0.030905224,-0.003771136,-0.027924128,0.03135027,0.031902038,0.020171508,-0.01922714,-0.04674832,0.051559437,1.5474007e-34,0.038700227,-0.109041914,0.032409087,-0.04309934,-0.12668699,0.13398239,-0.007835276,-0.15335934,0.0120492065,0.031043015,0.06628975,0.04969686,0.11922572,0.013467818,0.01739598,-0.010702498,-0.0632097,0.06056456,0.028710525,-0.07105936,0.014051269,0.058018953,-0.033011768,0.036120567,0.069576204,-0.031173436,-0.0053523276,-0.00652843,0.038051754,-0.080162145,0.030446643,-0.011537598,-0.10811254,-0.004564166,0.05104803,0.011959766,-0.07117826,-0.022281379,-0.052177638,-0.054850146,0.009440331,0.07995053,-0.014005882,0.076014526,0.002151328,0.034051053,-0.067116804,-0.0022068943,0.017336313,-0.002542822,0.023038806,-0.0028615152,-0.04292345,0.018028116,0.047003567,0.058701284,-0.0006714057,-0.03386861,0.015550356,0.024152922,0.022347286,0.049625177,-0.049669866,-0.0096355835,0.03466483,0.023103613,0.024986977,-0.017878072,0.08241427,-0.024825677,0.11328446,0.101095855,0.010541018,-0.005186686,-0.08537938,-0.046925224,-0.01599703,0.02914386,-0.038101234,-0.053103372,-0.011676988,-0.023974976,-0.027136125,-0.06454415,-0.04244577,0.009769425,0.02430012,0.16213292,0.04078707,0.040355183,0.011970901,0.027172575,-0.05440132,0.014156566,0.06269616,-3.1152407e-08,0.0033327828,-0.046124723,-0.045023333,0.008015714,0.010383865,0.022093924,-0.0011677943,-0.08727763,-0.041101586,0.013050031,0.0369127,0.019050159,0.021907467,0.026544143,0.054617908,0.049299125,0.106516376,0.033763267,0.019341543,0.06436072,-0.08346853,0.046389263,-0.08661236,0.016458986,-0.0068779243,-0.0927287,0.013910634,0.045639873,0.06429951,-0.0505795,0.04324122,-0.014695319,0.073026314,-0.08413354,-0.017131701,-0.012477799,0.02205301,-0.06897439,0.010515853,0.023149751,0.029006777,-0.049441386,0.025816582,-0.03317014,-0.11012314,0.017140064,0.043780804,-0.102817945,-0.00036935377,0.08975685,0.015005617,0.08782953,0.05860413,0.015912823,-0.061275505,0.009249228,0.04124338,-0.056543134,0.007195521,-0.067150705,0.02785893,0.01082695,0.12179745,0.009654659 +5.5.1.35,"The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. The product is a precursor of (+)-cis,cis-nepetalactone, one of the stereoisomers responsible for the psychoactive effects catnip has on cats.",384,0.99999994,-0.009276459,0.01585876,-0.02852079,0.016752206,-0.00015604054,0.044313494,-0.036407102,0.05681512,0.06351927,-0.012092185,0.028696876,-0.063353755,-0.025274927,0.07261991,-0.06832676,0.048736528,-0.03450063,0.04995339,0.048556887,-0.008478038,0.0137847625,0.014216383,0.017489612,-0.017209439,-0.03945623,0.083229676,-0.07207916,-0.04124482,0.026619596,-0.019617507,-0.063338295,0.021810973,-0.03460896,0.005396913,-0.018695062,-0.011359096,-0.054762945,-0.04465583,0.015268025,0.081213646,0.03242451,-0.020900145,-0.054551695,0.009330757,-0.028694041,-0.07265451,-0.024321675,-0.030521566,0.04293578,-0.000253577,-0.10281784,-0.014486614,-3.495089e-05,0.02618605,-0.04725113,-0.017195296,0.05177081,-0.023653897,-0.0066163363,0.021386301,0.07060442,-0.034572355,0.00033909918,0.009409858,0.10467823,-0.0037591814,0.0052249776,0.006355708,0.029841254,-0.018775415,-0.05653656,-0.05144458,-0.038155083,-0.036593143,-0.02100317,0.06907383,-0.024772,0.00965501,0.05747824,-0.028123343,0.06646753,0.117855005,0.043997552,0.0654592,0.12386161,0.0740959,0.005228186,0.010416919,-0.02933841,0.030760247,-0.026774548,-0.06737903,-0.037762545,-0.011613844,-0.07046785,0.015747827,-0.050313465,-0.0015400317,-0.038799573,-0.003019518,0.017620685,0.01162009,-0.101074055,-0.027232945,-0.097922675,-0.0048405956,0.007962857,-0.013310071,0.027261863,0.053601403,-0.07719658,-0.081463724,-0.029494878,-0.025709309,0.04597618,0.13770188,0.00423006,0.017161695,0.03782535,-0.069601305,0.03909111,-0.049128044,-0.036820427,0.021113299,-0.030448448,0.020075746,-0.12518068,1.8518909e-34,0.090562776,0.0030903106,-0.050412048,0.041993402,0.083432764,0.040492795,-0.065300666,0.033519696,-0.13863786,-0.06112801,-0.061597794,-0.01919837,0.0024423862,-0.0044631027,-0.043648742,-0.058440212,0.017514499,-0.05032558,0.06843722,-0.04981759,0.024930341,0.05902961,0.033214934,0.07198191,-0.0006849692,-0.012488004,-0.12605824,0.017522654,-0.04163726,-0.03060465,0.023570169,-0.07176795,-0.09392601,0.016337525,-0.029734844,-0.019415552,-0.0028082146,-0.06761654,-0.0041521117,0.049008235,-0.028332368,0.05568442,0.023766061,0.0063631427,0.05231548,-0.01219831,-0.08837111,0.074114844,0.04578627,0.06883079,0.063787855,-0.0275537,0.0088480795,-0.07131315,-0.10903627,0.044909712,-0.04262552,-0.042320784,-0.0061176363,0.0546925,-0.027805757,-0.00645768,0.010517661,-0.00040245336,0.022921186,0.024022259,-0.03425401,-0.06463863,0.11179345,0.086609796,-0.0647828,0.0673328,0.027461028,0.014652817,0.049600422,-0.054685652,-0.06262373,0.017112492,-0.03593798,0.079909235,-0.01652039,-0.004761244,0.004914314,-0.016314756,-0.06738377,0.016508896,0.033733223,0.0039391723,-0.031211998,0.027722083,0.039431293,0.011793731,-0.023293253,-0.043545093,0.051665954,-4.164626e-34,0.037284203,-0.11494662,0.042148035,-0.05221317,-0.12031525,0.13625532,-0.014174211,-0.14722408,-0.0033611832,0.020071488,0.06912711,0.055192955,0.11021103,0.022514058,0.03467267,-0.017306402,-0.06054671,0.05433386,0.02097154,-0.059330247,0.017167345,0.053618066,-0.028743133,0.04364793,0.05372154,-0.023034833,0.0066034943,-0.0025090901,0.034160495,-0.06480161,0.028108897,-0.011675026,-0.12338518,-0.017426888,0.051295836,0.011389384,-0.07841705,-0.02307186,-0.056928758,-0.060212597,0.002914982,0.085228235,-0.009857859,0.074738055,0.0049676206,0.03363707,-0.065003134,-0.011149308,0.018045839,-0.008605788,0.012465086,0.0058129784,-0.04466267,0.012929603,0.042608287,0.04941613,-0.014430598,-0.021120643,0.018926974,0.025350874,0.01885636,0.03549211,-0.06012463,-0.0083321575,0.03560698,0.035981975,0.034452427,-0.021532724,0.087287635,-0.022415997,0.12045027,0.11081256,0.0022914584,-0.005126496,-0.07743094,-0.049074102,-0.020797608,0.024000399,-0.045307484,-0.05615865,-0.019006921,-0.028631598,-0.02053534,-0.058446072,-0.036611367,0.00026790533,0.027110333,0.16789982,0.053623684,0.051912963,0.023559595,0.027651198,-0.054491807,0.008217552,0.059849303,-3.2528906e-08,0.004568261,-0.038695782,-0.02429026,-0.003994635,0.0025354312,0.017414944,-0.00023639116,-0.09306629,-0.02639995,0.012226835,0.047286898,0.012197318,0.017030656,0.03662315,0.06524891,0.053696666,0.10582399,0.051995635,0.031895828,0.056092538,-0.07855911,0.03910996,-0.08228954,0.01904315,-0.012385267,-0.09331458,0.018818546,0.047159057,0.055324547,-0.037844222,0.0470934,-0.007926564,0.078174055,-0.082515694,-0.021933857,-0.0093339,0.011865446,-0.06522026,-0.00042611183,0.0101770805,0.034677528,-0.046743326,0.011910324,-0.028951203,-0.0922521,0.022031732,0.06033655,-0.09963201,-0.0028449744,0.08480469,-0.0022299092,0.09045282,0.055363547,0.019025352,-0.073056705,0.0022648636,0.0396785,-0.05102026,-0.0036597424,-0.06455098,0.027549645,-0.0023413883,0.1257386,-0.0015857859 +6.2.1.61,"The enzyme catalyses the activation of salicylate to (salicyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein, which is often a domain of a larger non-ribosimal peptide synthase. The PmsE enzyme is involved in pseudomonine biosynthesis and transfers the activated salicylate first to itself, and then to a PmsG protein. The PchD enzyme is involved in pyochelin biosynthesis and transfers the activated salicylate directly to the PchE protein.",384,1.0,-0.015128836,-0.05578545,-0.07392796,-0.006581815,0.10087822,0.052180856,0.002022003,0.07011484,0.06353791,0.03212579,0.017074227,0.0492876,-0.029135352,0.04196935,0.0030676434,0.085109435,-0.11542119,0.011152448,0.029891638,-0.033214804,0.10288234,-0.0108293975,-0.033219907,0.0040979655,-0.01762231,-0.055986892,0.07931429,0.0020640309,-0.010609425,0.003174904,-0.032089718,-0.027976813,0.08202071,0.012507901,0.046404164,0.16048823,-0.011500982,-0.05067568,-0.018090278,-0.019035537,0.07854249,-0.054371767,-0.0371031,-0.049183898,-0.014511643,0.033007264,-0.0056482404,0.052128807,0.03445503,-0.046773255,-0.092408486,-0.08189846,-0.05031011,-0.057765562,-0.059836674,0.08991385,-0.070169576,-0.05841661,0.011427704,-0.041945204,-0.054163717,-0.00658432,-0.052642494,-0.01777873,0.06653665,-0.10765089,0.04625842,-0.030798662,0.047111593,-0.05990604,-0.026302429,-0.031898577,-0.059444148,0.0038155932,0.061664615,-0.037034016,-0.011868534,0.009460227,-0.0033205186,-0.053326067,0.05334749,0.013915177,0.022220206,0.047780707,0.06554719,0.02593954,-0.0020379624,0.002506791,-0.00082551327,-0.04116285,0.030343765,-0.0780498,-0.055830535,-0.019162808,-0.06926809,-0.0059588896,0.0020671652,-0.04349922,-0.00284142,0.037615135,-0.0071236016,0.05338836,-0.05054239,-0.09627161,0.0032506674,0.02801766,-0.057096012,0.03301134,-0.0023164756,0.00019664867,-0.0150983455,0.049300525,0.056810733,0.005212034,0.012850321,0.086852774,-0.048574127,-0.009536656,-0.0256811,-0.0510237,-0.056543972,0.003057054,0.034037042,0.12017951,-0.054121744,0.04933371,-0.11118997,2.6814826e-33,0.031522732,0.049431894,0.0660529,-0.06707033,-0.09567031,-0.023225376,-0.01716097,0.01877816,0.06381108,-0.04231878,-0.049890682,-0.08208169,0.051895797,0.022173246,0.0038790167,-0.11161111,0.0039920304,0.06233087,0.082590476,0.04422462,-0.049116164,0.094049595,-0.011563847,0.027724095,0.018849488,0.013994844,-0.028521508,-0.020800821,0.06922125,-0.0014995721,-0.0010039046,-0.015873099,-0.069221854,0.0072278604,-0.017565256,-0.04547439,-0.030476078,-0.09941081,0.040044792,0.031504195,-0.09581919,-0.04095561,-0.009517577,-0.054274846,-0.014332071,-0.07586809,-0.044451524,0.054994624,0.033517066,0.014803422,0.027417868,-0.007958348,0.104567125,-0.011872541,-0.10791164,-0.041080944,0.006802362,-0.08800879,0.018345725,0.026191551,0.08175316,-0.03941013,-0.01973358,-0.005779172,0.006266261,0.040189404,-0.019504433,-0.04603067,0.041174382,0.13819145,-0.01881103,0.053136468,0.01492167,0.033131957,-0.011383227,-0.035930835,-0.059138164,0.09057483,0.029751461,0.025488142,-0.016103365,0.05768292,-0.021717751,0.067322135,-0.0070112427,-0.0531813,0.04490502,-0.06589614,-0.060912527,-0.0024068835,-0.0106959855,-0.07191911,-0.042665232,0.09596927,0.0075706593,-3.6019208e-33,0.103584275,-0.07983525,-0.016429907,-0.050681543,-0.049126238,0.032457884,0.044062678,0.020591235,-0.04850338,-0.037828382,0.03080511,-0.043524515,0.013629188,-0.08565753,0.009592425,0.006081731,-0.016307324,0.05339358,-0.05157051,0.020119295,-0.030619565,0.06769528,0.08066846,0.06964004,0.033641797,-0.01746009,-0.044402663,0.08657691,0.008241653,0.07737202,0.012414468,0.030570453,-0.08083422,-0.036829397,-0.05298482,0.06537266,-0.039655503,0.043544523,0.053211104,0.068846,0.07392823,0.05969064,0.008856164,0.07300413,0.03620475,0.09971382,-0.01673486,-0.010428951,-0.011163127,-0.102696486,0.029358417,-0.00040553612,0.09098192,-0.040910274,-0.007118756,0.060894027,0.015298815,-0.004761242,-0.03028303,-0.088965155,-0.08138959,-0.102785625,-0.0010027022,0.0054211607,-0.027015965,0.04768131,0.03273998,-0.010213217,0.0348093,-0.02690756,0.055443745,0.076504156,0.06391218,0.06637312,-0.017995648,-0.016122403,-0.031814717,-0.032071978,0.012314484,-0.057482816,-0.02675145,-0.037148308,-0.009431987,-0.038731303,-0.01384097,0.00076581497,0.062253106,0.020174062,-0.0043924917,-0.002822603,-0.013014848,0.04209655,0.03743932,0.038197625,0.03366328,-3.5329336e-08,0.076231845,-0.10242141,0.052279234,-0.06667496,-0.040036112,0.017102301,0.01699223,-0.027306784,-0.07256381,-0.02735181,-0.0684326,0.04090303,-0.020305634,-0.02673061,-0.0031170526,0.07381037,0.02027742,0.04673847,-0.015198253,-0.10439883,-0.062267303,0.037521977,-0.06174366,0.08650904,0.041797508,0.00038734707,0.080915734,0.024293358,-0.011472355,0.017178949,0.07603539,-0.014029134,-0.015081765,0.027879098,-0.0038495564,0.065482914,0.011731308,-0.02639158,0.019572781,-0.015162529,-0.011460319,0.0016945365,-0.06146427,0.011285246,0.047090583,0.028258502,0.012975132,0.0028200482,0.023258781,-0.01770492,0.054989118,-0.0009906283,-0.010954695,-0.06261678,-0.10507833,0.020001363,-0.054370664,-0.10988412,0.04205589,-0.03168624,0.06055932,0.059755698,0.16796006,-0.03347314 +7.1.1.9,"An oligomeric membrane heme-Cu:O2 reductase-type enzyme that terminates the respiratory chains of aerobic and facultative aerobic organisms. The reduction of O2 to water is accompanied by the extrusion of four protons. The cytochrome-aa3 enzymes of mitochondria and many bacterial species are the most abundant group, but other variations, such as the bacterial cytochrome-cbb3 enzymes, also exist. All of the variants have a conserved catalytic core subunit (subunit I) that contains a low-spin heme (of a- or b-type), a binuclear metal centre composed of a high-spin heme iron (of a-, o-, or b-type heme, referred to as a3, o3 or b3 heme), and a Cu atom (CuB). Besides subunit I, the enzyme usually has at least two other core subunits: subunit II is the primary electron acceptor; subunit III usually does not contain any cofactors, but in the case of cbb3-type enzymes it is a diheme c-type cytochrome. While most bacterial enzymes consist of only 3--4 subunits, the mitochondrial enzyme is much more complex and contains 14 subunits.",384,1.0,-0.06171145,-0.054632302,-0.10839232,-0.0033226905,0.058377326,0.0019522218,-0.02032431,0.058344748,0.04055359,-0.061022893,-0.06217734,-0.033866495,-0.038643688,0.020468915,0.012205847,0.029436871,-0.05286223,0.013463108,-0.054507636,-0.06387733,-0.0057934443,0.03531278,0.024299996,0.008199387,-0.016085915,-0.005547525,0.06377835,-0.049805164,-0.08858928,-0.081810415,0.0043836944,-0.03138555,0.1074019,-0.053263035,0.11470533,0.02893282,-0.05634925,-0.048670292,-0.059667856,-0.033186328,0.03467761,0.09354895,0.022807986,0.030737495,-0.036291312,0.017248014,0.08043528,-0.03150079,0.02542925,-0.040787462,0.014597103,-0.068682626,-0.085830145,0.11414933,0.02936587,-0.01795115,-0.036803704,-0.048185114,-0.0010118709,-0.017122086,0.014502691,0.01809556,0.0059469924,-0.020855201,0.05452528,-0.011810805,0.02634525,-0.08382362,-0.0035393562,-0.054903783,-0.03600893,-0.06631469,-0.081516586,0.017226163,-0.043502517,0.04640852,0.10750154,-0.0029963783,0.04319896,0.008917022,-0.036629625,-0.010555331,0.06606423,0.13834631,0.04766365,-0.020626519,-0.011605947,-0.03786982,-0.051907625,0.04054113,-0.034364678,0.055898536,-0.003772361,-0.06991708,-0.03568051,-0.023533974,0.073137425,0.11339199,0.017068675,-0.011339765,0.04419172,0.092725456,0.049310982,-0.05839508,-0.02530158,-0.06891667,0.077940084,0.09644478,0.059601437,0.022523414,0.05854102,0.0067467093,0.037524812,-0.03321791,-0.02697674,0.020730963,0.0510632,-0.036924027,-0.028240724,0.078299716,0.027895223,0.0011564746,0.05797029,-0.058147047,-0.027063722,-0.02167511,-0.11556115,1.5460655e-33,-0.01405301,-0.0045492738,0.02211244,-0.020339575,-0.029594256,-0.020095736,-0.114014335,-0.02262229,0.016738448,0.0302524,-0.07459127,-0.048442822,0.049081873,-0.007938839,0.010307537,-0.079335,-0.05418738,-0.016451824,-0.0113923345,-0.0027142698,0.0592694,0.048120316,-0.03856121,0.012837615,0.061887436,-0.03305243,-0.013840315,-0.05267637,0.0028135958,-0.00011928772,0.06813715,-0.09822958,-0.11327946,-0.0081419805,0.031911798,-0.035533983,-0.044942718,0.042812526,-0.021661377,0.03170699,-0.029476505,0.02899541,-0.021883728,-0.01766156,0.11526891,-0.09250112,-0.06686933,0.07709714,0.0036038165,0.027430305,0.033061612,-0.037621435,0.11828305,0.019607335,-0.0031131622,-0.0012238726,0.02640595,0.07544298,0.037289504,0.052254863,0.12068096,0.10518004,-0.10139348,0.061627436,0.009377895,0.044926222,-0.049998764,-0.022699328,0.011730164,0.08534979,-0.05669577,-0.019718684,0.06071586,-0.0058420706,-0.0069770673,-0.037394788,-0.041419476,-0.043641284,0.064000875,-0.009108968,0.02280432,-0.034709003,0.064170904,-0.030667495,-0.08332923,-0.030526465,-0.018436221,-0.015699554,-0.060329415,-0.0075970707,0.0553767,-0.06595837,-0.043035235,-0.040285055,-0.018933922,-2.8940807e-33,0.06998077,-0.058741074,0.08054149,-0.14308289,-0.011201683,0.07303372,0.032883,-0.024740666,-0.013791011,-0.046554107,0.10806219,0.007752969,0.010793436,0.03379864,0.038019456,-0.0042104176,-0.10734444,0.029582445,0.00033276159,0.018035045,-0.019549206,0.004772612,0.006194244,-0.019651536,-0.01710859,0.010155522,-0.03200429,0.020945186,0.119473904,0.02650533,-0.052304886,0.08845726,-0.017587014,0.0062209424,-0.10082833,0.022415075,0.011381827,0.00032574814,-0.015208621,0.04245917,-0.02181415,0.01435787,0.059255607,0.026095467,0.033514295,0.107307896,-0.098501444,0.023122454,-0.046467233,-0.016694851,0.01113183,-0.014150199,-0.047740735,0.03450812,0.05430351,0.011852876,0.024926135,-0.067115806,-0.05692531,-0.04171443,-0.0040813047,-0.038929507,0.08962996,0.038251948,-0.011358527,0.006288408,-0.025031392,0.06891838,-0.014214844,0.008684188,-0.026335366,0.050421197,0.019533033,-0.037634533,-0.00081396213,-0.015877053,0.018019386,0.038743842,0.024460968,0.0006894831,-0.020184884,0.06637757,-0.0031172389,-0.045750074,0.07627334,-0.08277866,-0.03133658,0.07924623,0.008863477,0.009407973,-0.033930764,-0.03628152,-0.013818892,0.09120279,0.0055337674,-4.64444e-08,-0.01640266,-0.06340652,0.05025775,-0.02128531,0.008121161,0.02779766,0.018288843,-0.004040239,0.037486654,0.026843457,0.004206121,0.081608586,-0.047067706,-0.09664963,0.064237535,0.09670554,-0.025365673,-0.058538888,0.05421848,-0.024079809,-0.011668666,-0.021542015,-0.0774709,0.08059249,0.013171835,-0.05986008,-0.09466594,0.009844478,-0.042553134,-0.0062695094,0.024340495,0.061408404,0.06663144,-0.046591774,-0.08056288,-0.07346537,0.0035319093,-0.04267651,-0.08248968,0.033736337,0.029101295,-0.027712347,-0.09013059,-0.021683183,0.05420934,-0.018070161,0.0072531905,0.067926444,-0.026984222,-0.04458462,-0.0067712176,-0.027772173,0.0027936199,0.019506073,-0.08628458,0.07851617,-0.016321307,-0.07841817,-0.014401642,-0.014285559,0.09113741,-0.021842994,0.10440329,-0.009527961 +7.4.2.13,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in Clostridioides, interacts with an extracytoplasmic substrate binding lipoprotein and mediates the import of L-tyrosine. L-phenylalanine is also tranported however with lower efficiency.",384,1.0,-0.07119128,-0.05243647,-0.038612127,-0.04282387,-0.026438972,0.0038342385,0.049811665,0.06248403,0.066070154,-0.07056241,0.06466912,-0.058607377,-0.016247945,0.12176435,-0.013859739,-0.041327443,-0.06307474,0.008377968,0.027831947,-1.2874825e-05,-0.0033642682,0.1182626,-0.008940486,0.05682881,-0.07626352,-0.007833756,0.015054389,-0.031301588,-0.025732033,-0.023804756,-0.09020167,-0.009455741,0.008882576,0.0027319791,-0.015706405,0.08978646,-0.024160301,0.01966613,0.09384254,0.038321767,0.1012151,-0.061113693,0.06394605,0.028242838,-0.15690961,-0.03959447,0.0122245755,0.026577316,-0.01655025,0.026657054,-0.023821734,-0.05034526,-0.031776194,0.056144845,-0.017054174,0.057292577,-0.039143294,0.022208009,0.010831091,-0.03195313,0.01734021,0.041305378,0.09478461,0.07899064,-0.005046771,-0.095457785,-0.05379402,0.013308008,0.013948069,-0.048467454,-0.05622244,-0.08289579,-0.04475803,0.034915872,0.052675545,-0.01941507,-0.017028118,-0.00816789,-0.026935494,-0.042349905,0.026569642,-0.031144405,-0.046563447,0.057871364,0.06558925,-0.009779328,0.00059540116,0.016595498,0.011894553,-0.036757294,0.016747298,-0.04525188,0.03765127,-0.036624514,-0.1059388,-0.0059648254,-0.008050961,0.016323084,-0.023432357,0.025734788,0.015845435,0.044311322,0.033888463,-0.011369902,-0.047520224,-0.050590802,0.01464165,0.010265658,-0.056858823,-0.034588832,0.0059395,0.026648158,0.08547398,-0.061356902,0.03476539,0.03689599,-0.02000732,0.006689868,0.021484116,0.01794432,-0.05667025,-0.08933789,0.039292272,-0.00095635053,0.033678234,0.069688104,-0.044384718,9.062143e-34,-0.04080024,-0.03819573,0.032152873,0.013796258,0.003278962,-0.033092305,-0.008677765,-0.02700533,0.011222278,-0.087418884,-0.03227431,-0.028384522,0.0019143996,0.12152749,-0.027574992,-0.043117635,-0.118409224,0.08907146,0.1132862,-0.03570842,0.046359017,0.093336165,0.037503175,-0.024193713,0.09504004,0.028494693,-0.039071593,-0.04664142,0.07080047,-0.009797945,0.017197222,-0.036901247,-0.073761836,-0.031089332,0.008642951,-0.024439871,-0.079948075,-0.054314107,0.0018098826,-0.04899428,-0.08923671,-0.029438213,-0.07170854,0.05387405,0.022092085,-0.025126342,-0.03274676,0.07795425,-0.051044405,-0.026612474,0.063914284,-0.15589486,0.040307157,-0.098146304,-0.028857062,-0.016495375,-0.029991077,0.026444376,0.0015594278,0.06680912,0.09024575,0.13374044,-0.043021716,0.006837725,0.06172845,0.007888461,-0.08048839,-0.119696446,0.039551232,0.07936427,0.0016912358,-0.018392839,0.058925513,0.070911594,0.057032768,0.006780088,-0.105682954,-0.081178024,-0.0012857415,0.026461763,-0.056528244,-0.112644784,0.03985079,-0.009464597,-0.048411045,-0.041941326,-0.022642465,-0.09359343,0.028149815,-0.024389552,0.060002007,0.02440734,-0.08119963,0.07825888,0.015652824,-2.1831698e-33,0.0684036,-0.059909258,0.08317677,-0.033074513,-0.04037212,-0.0032756464,0.004872801,0.0030321013,0.032203946,-0.039426874,-0.0022555229,0.045452513,0.015680434,-0.047838252,0.047957953,-0.044915125,-0.011101803,-0.0006782108,-0.017248226,-0.03556104,-0.010530047,-0.0075717447,0.01637101,0.088918366,-0.023541944,0.025121942,-0.04167418,0.090139434,0.010031531,0.048183806,-0.054474685,0.037738442,0.014457568,-0.039051563,-0.08385421,0.07902732,-0.014381461,0.030914806,0.005732391,0.0033587092,-4.9759034e-05,0.018694313,0.022116015,0.016361153,-0.009397334,0.07747496,0.0031718428,0.017255455,0.02677301,-0.050817568,0.00063149194,0.007061708,-0.006134728,-0.03743231,0.054915484,0.11109604,-0.057369065,-0.046711136,0.04478508,-0.09871419,-0.060817942,-0.06605505,0.0378423,0.013398806,0.012422228,-0.011722657,0.005101669,-0.055108994,-0.017376017,0.024845136,0.0899868,0.002817307,0.022902213,0.032698404,0.018145798,0.009089853,-0.011634747,-0.04334056,-0.038657617,-0.0029454054,-0.06067681,-0.008586845,0.001451152,-0.0197465,0.07357745,0.027675083,-0.0045447014,0.0021796227,0.032418225,0.038907718,0.010986739,0.019856453,-0.015992174,0.04283329,0.0026296722,-3.853677e-08,0.063575216,-0.0736509,0.055576865,-0.07587451,-0.029731048,0.02549507,-0.0390682,0.034138132,0.06166714,0.051075153,0.029264458,0.12207292,0.02118018,0.04687753,0.063087836,0.09571024,-0.04255193,0.023611173,-0.029118206,-0.086982034,-0.026722165,-0.019571532,-0.040083252,0.057371445,0.06476778,-0.024165547,0.010343808,0.06270289,0.0066631315,-0.07808186,0.07443654,0.02299496,0.015428769,0.016891122,-0.0024830697,0.08225938,-0.07039264,-0.032005064,-0.068431795,0.07965126,0.013139957,-0.015900595,-0.09688816,-0.010941382,0.03957257,0.01984908,-0.06461012,0.07105471,-0.07359042,-0.016403869,0.037259825,0.014010913,0.0004252098,0.0014229007,-0.03351281,-0.020179225,-0.06728525,-0.023181096,-0.0073075755,-0.038111832,0.015168089,0.054236084,0.18758667,-0.023812067 +1.1.1.422,"The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. The enzyme exhibits a strict anti-Prelog enantioselectivity. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC 1.1.1.423, ephedrine dehydrogenase.",384,1.0,-0.08458174,-0.021266757,-0.012917225,-0.040531844,0.06270914,0.062525496,-0.02240377,0.011487549,0.027072236,0.058398794,0.014987743,-0.04148691,-0.10614436,0.070711926,-0.00712071,0.08856602,-0.028577588,-0.037570216,-0.00046981007,-0.06501628,-0.0023196135,0.0015925741,-0.042954613,0.017208893,0.004407502,0.06595423,0.07858451,0.053415984,-0.07382755,-0.10549009,0.03699839,-0.016853672,0.054325387,-0.048743628,0.02795948,0.13131094,-0.12644209,-0.033422373,0.09773371,0.0022600072,0.019698445,0.06716516,-0.06595308,-0.07449354,0.019268584,-0.07532547,-0.022293467,0.027841296,0.0030340096,-0.043416902,0.0006643889,0.00660872,0.013190396,0.07066148,0.03554669,0.002931197,-0.1054261,6.706464e-05,-0.022492213,-0.048184216,0.018740874,0.024856923,-0.03398509,-0.019082727,-0.037047636,-0.029886873,0.049319796,-0.06834277,0.039198335,0.025248261,-0.061681494,-0.07209204,0.00080937165,0.10945543,0.013246679,-0.016878165,0.0024204669,-0.026297623,-0.0041177007,-0.023092851,-0.0093961,-0.02148819,0.07955273,0.047017444,0.07316648,0.011790267,0.011392677,0.00079889584,0.04237483,0.047394354,0.04001516,-0.014973224,0.019172236,-0.04627002,-0.009703583,0.020653965,0.012104759,-0.0041483277,-0.012241901,0.023027817,0.0016972384,-0.019701246,-0.07988814,-0.041233752,-0.09441057,-0.014009556,0.077314325,-0.0043478017,0.0012333957,0.013060234,-0.0029667073,0.029225077,0.07790276,-0.002508068,-0.06882459,0.0120016085,0.016462035,-0.08172685,0.04002927,0.0257744,0.006754705,-0.020263001,0.08958318,0.11373738,-0.055258047,0.07101309,-0.15435974,4.3982687e-34,0.08693992,0.008006194,0.051866017,-0.04004718,0.006718886,-0.03997045,-0.07488646,0.005209542,-0.03102758,-0.045451656,-0.098416984,-0.0060954113,0.09889673,-0.015878372,0.011635037,0.0048516267,-0.05303698,0.039202914,0.04836497,0.00019985778,-0.04359269,0.0018762375,-0.06581562,0.024936456,0.00028871847,0.03877526,-0.025559857,-0.015748518,0.007851462,0.016686473,-0.011415881,0.010074696,-0.09948476,0.07767426,0.022708796,0.05029847,-0.013648655,0.0068635354,0.02768186,-0.0033740965,0.001554013,0.0070264204,-0.058168944,0.033744313,0.037292585,-0.042083595,-0.05579302,0.08016821,0.024802664,0.07189934,0.08593559,-0.021174503,0.08966887,-0.04856459,-0.07725548,0.119584545,0.012826704,-0.03055181,0.111359924,0.048153292,0.009157589,0.0003635744,0.015988687,0.007613874,-0.003515997,-0.03838448,-0.08009978,-0.08888161,0.033465896,0.061585654,-0.087175086,0.017667463,0.11851928,0.04653108,0.024363019,0.009625035,-0.098666966,0.018938724,0.0018277712,0.059435476,0.008219637,-0.069541976,0.017869566,-0.08274812,-0.039471995,-0.06931753,-0.02676638,-0.08453974,0.04641855,0.042662974,0.041648168,-0.07430624,-0.05051764,0.064684674,-0.0062300563,-1.478539e-33,0.1279326,-0.069845736,-0.023527555,0.0019379681,-0.05323149,0.09606028,0.06414074,-0.045086134,0.035766833,-0.001067734,0.14175011,-0.0003190246,0.012204339,-0.011651034,0.06595554,0.018079102,-0.0032029566,0.050191257,-0.0025434226,-0.07494684,0.011353554,0.052145734,-0.0830941,0.045895398,-0.014307298,0.06340859,-0.046042845,0.04112099,0.048625927,0.028517907,0.020235546,0.01807216,-0.007337319,-0.04325581,0.0006029246,0.07270071,-0.06252001,-0.0122131305,-0.0064874855,0.031937603,0.011122484,0.023149302,-0.0017072795,0.054041304,0.026972197,0.09463565,0.0028687918,-0.00891161,0.014528594,-0.10939485,0.04208469,-0.013232305,0.02480648,-0.028649004,-0.0032708799,0.046567425,-0.017902954,-0.040564097,-0.014204949,0.008660024,0.005989999,-0.057521187,0.10345105,-0.019041136,-0.042208467,-0.020364879,-0.026595967,-0.004285718,0.07287206,-0.024524195,0.0057056374,-0.047133535,0.04590191,0.075525865,-0.014606387,-0.016951857,0.021496171,-0.042882882,0.038367324,-0.02675765,-0.039107263,0.019247483,-0.046309087,-0.08397009,-0.06146348,-0.040601283,-0.047977295,0.00547624,-0.02092726,0.06873325,-0.0055711586,-0.0026126641,-0.023954535,0.100424215,0.07833621,-4.869202e-08,0.06409547,-0.08705211,0.002761171,0.0055985097,-0.0138501525,0.0068409806,0.07047963,-0.0016174212,0.100680836,-0.09920278,0.028287176,0.025120864,-0.002661975,0.029275348,0.056324355,0.017856529,-0.0042298227,-0.008352303,-0.041909873,-0.10976047,-0.05597671,0.018035576,-0.060639564,-0.04144351,0.022633852,-0.04627394,-0.039892416,0.04157343,-0.045252692,0.009682023,-0.05765505,0.06774443,0.01958664,0.022640603,-0.04585689,0.036881436,-0.06440384,-0.025184901,-0.028403152,0.046354823,-0.0046627535,-0.0051179216,-0.13344778,-0.014475852,0.012402366,0.006695199,0.019412361,0.024015598,-0.036280558,-0.03369349,0.03210198,0.06141776,-0.01152639,0.0018376401,-0.12889268,0.08514096,-0.037914094,-0.10206594,-0.014622585,-0.10405746,0.023068842,-0.016363278,0.08430032,-0.005126374 +1.1.1.423,"The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It exhibits a strict enantioselectivity and accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC 1.1.1.422, pseudoephedrine dehydrogenase and EC 1.5.1.18, ephedrine dehydrogenase.",384,1.0,-0.083175726,-0.02986588,-0.020735292,-0.057585035,0.051335793,0.061478436,-0.035221677,0.013747733,0.0196413,0.039648745,-0.014516212,-0.06605736,-0.09928567,0.058840793,0.0035345182,0.083666846,-0.0299961,-0.019946191,-6.757922e-05,-0.05002811,0.018369544,0.018108832,-0.059626963,0.012480957,-0.020008849,0.08664234,0.090392604,0.056750946,-0.08901319,-0.12843442,0.054884754,-0.017576834,0.050164256,-0.056609172,0.034259215,0.14245774,-0.11375376,-0.029897489,0.09124754,0.0031525919,0.020842263,0.08682333,-0.05011235,-0.09362784,0.01399989,-0.073314495,-0.017833197,0.030392572,-0.008960217,-0.05975573,0.012678075,0.0046700374,0.01314426,0.07771306,0.03317633,0.002571316,-0.08436937,-0.012059443,-0.033803076,-0.047510583,0.012878999,0.020176066,-0.031354357,-0.023489319,-0.06777162,-0.044678446,0.055023216,-0.07551752,0.029705336,0.009215564,-0.057888556,-0.072164536,-0.005580288,0.11724937,0.0061771343,-0.013445643,0.015695138,-0.036928203,-0.0020413452,-0.040121827,-0.019016063,-0.018297894,0.07210975,0.025078598,0.064931646,0.0062735584,0.009118599,-0.010351585,0.025315717,0.05687622,0.052907214,-0.013345193,0.026222201,-0.054662943,0.020002805,0.017288806,0.030682636,0.031369116,-0.0059414995,0.011481848,-0.0068123047,-0.02447438,-0.08682267,-0.04755773,-0.081085466,-0.008035834,0.09198013,0.0024368153,0.003833255,-0.007818431,-0.025798667,0.028132336,0.082180575,-0.009436502,-0.05087328,0.0041176653,0.023476513,-0.098652855,0.038058266,0.017466038,-0.008083246,-0.029115545,0.08657519,0.10465448,-0.04198719,0.07113552,-0.15316013,1.5527481e-33,0.07776827,0.009211314,0.040412147,-0.030802498,0.005606958,-0.039481405,-0.0874703,0.01784243,-0.004189549,-0.07788999,-0.08530845,0.0030903171,0.1074089,-0.010457655,0.025147963,0.011184029,-0.041798502,0.06360726,0.032674696,-0.0037547338,-0.039233923,0.008360693,-0.054749332,0.040538162,0.00050562085,0.035306282,0.00109651,-0.0332002,-0.0042658104,0.0023303332,-0.006474645,-0.0015532227,-0.08827687,0.08354542,0.025101522,0.06687649,-0.016575603,0.012350402,0.012874107,-0.0030270375,0.009575113,0.010795888,-0.06438986,0.043650255,0.035382744,-0.017012743,-0.057786923,0.09243136,0.0091179,0.085942574,0.075800896,-0.015698208,0.13611053,-0.05655148,-0.05954105,0.10963141,0.00036833977,-0.04408332,0.11540609,0.05123638,-0.006294189,0.01905909,0.0052544232,-0.0011978094,0.010402044,-0.02478452,-0.09531062,-0.06977508,0.03009523,0.065029785,-0.08105153,0.023122255,0.12720978,0.043826558,0.027512204,0.013264626,-0.106922746,0.0028242695,-0.017597292,0.048409652,0.014706999,-0.052186023,0.025378557,-0.08687458,-0.03610377,-0.047685694,-0.021984084,-0.07698185,0.044720456,0.0552518,0.021230392,-0.08188819,-0.041243184,0.052415837,0.00022839871,-2.1287729e-33,0.11046939,-0.06215075,-0.031013362,0.015393941,-0.020905029,0.10498622,0.047208827,-0.045170676,0.032157283,-0.011993304,0.10862141,0.0054257615,0.021197207,-0.02123984,0.05042876,9.009599e-05,-0.008088038,0.04177802,0.0042641624,-0.06729078,0.003514637,0.04871055,-0.08698315,0.025012325,-0.0071893567,0.070911795,-0.06144017,0.05953735,0.057697557,0.008214629,0.020216322,0.03491564,-0.011739326,-0.048653424,0.005865028,0.08272695,-0.0748058,-0.015422795,0.0007695964,0.029229235,-0.012332217,0.02360157,-0.0013810879,0.07286908,0.03977707,0.08986685,-0.0006024392,-0.016806321,-0.0073891804,-0.0941214,0.04494812,-0.02364304,0.010524584,-0.023998609,0.0002861786,0.046325766,0.0033274265,-0.020495502,-0.012584293,0.02053174,-0.0018487955,-0.04571391,0.0852655,-0.016274927,-0.062508285,-0.014835426,-0.016770098,-0.01952077,0.056663856,-0.010175071,0.0062617897,-0.03804108,0.061439734,0.07296249,-0.018071702,-0.014435758,0.0145657305,-0.043091577,0.016795991,-0.002877411,-0.0077644987,0.016373983,-0.042408355,-0.090389214,-0.0626062,-0.031906407,-0.04541104,-0.011714653,-0.043294854,0.059831742,-0.008747476,-0.014286533,-0.011310343,0.11334255,0.06243327,-5.2376777e-08,0.07396472,-0.065427184,0.01213301,0.012246075,-0.0066931588,0.00068572146,0.07627554,-0.011715701,0.10208471,-0.097252965,0.040786587,0.007732471,0.0037153899,0.04783703,0.08814271,0.0241893,-0.0021636349,-0.03258536,-0.032971375,-0.091832004,-0.046119202,0.008339471,-0.07397688,-0.018271646,0.031647865,-0.054636765,-0.022134656,0.024370955,-0.020893034,0.020975892,-0.04632588,0.067761905,0.027049221,0.012174552,-0.019608026,0.018630512,-0.06799747,-0.024029428,-0.02701398,0.04528214,0.0154171055,-0.00079924817,-0.14740206,-0.012367389,0.014183905,-0.0081813,0.011980771,0.033885833,-0.04169798,-0.03286716,0.02648108,0.042230785,0.007069306,-9.5796866e-05,-0.11888702,0.08754298,-0.027215246,-0.11080283,-0.011399272,-0.082218245,0.010625974,-0.00964975,0.0735433,0.0033013618 +1.1.98.7,"A bacterial radical S-adenosyl-L-methionine (AdoMet) enzyme that contains three [4Fe-4S] clusters. The enzyme, found in some bacteria, activates a type I sulfatase enzyme (EC 3.1.6.1) by converting a conserved L-serine residue in the active site to a unique 3-oxo-L-alanine residue that is essential for the sulfatase activity. While the enzyme from Klebsiella pneumoniae is specific for L-serine, the enzyme from Clostridium perfringens can also act on L-cysteine, see EC 1.8.98.7, cysteine-type anaerobic sulfatase-maturating enzyme.",384,1.0,-0.028214037,-0.08715142,-0.06754387,-0.006873365,0.0951617,0.050835636,-0.10025555,0.05151844,0.08392082,-0.049610358,0.012179121,0.011631145,0.0026444278,0.1336136,-0.03854105,0.07477089,-0.09525073,0.015620827,0.040061552,-0.014856714,0.075769305,0.04503814,-0.04960169,-0.020334056,0.03270515,0.03869855,0.03254171,-0.025554176,-0.10934643,-0.00972576,-0.013719377,-0.095835276,0.07435068,-0.01690596,0.09710108,0.058360457,-0.020335836,-0.005675574,0.057892025,0.0018945383,0.022720013,0.01210767,0.018582314,-0.06561321,-0.01821705,-0.0068556587,-0.039053645,0.03474201,0.023981368,-0.09382459,-0.07073934,-0.08425744,-0.03681492,0.053800795,0.0064668297,-0.019168917,-0.083952375,0.0032905599,0.020181175,-0.018023353,0.045068286,0.010478405,0.031545185,-0.041903254,0.02319407,-0.065394215,0.06099403,-0.08544826,0.027784383,-0.05435825,-0.067399085,-0.021008154,-0.027949382,0.07582341,0.0036740203,0.06277775,-0.036836028,-0.03894283,0.03174135,-0.06054492,0.017807234,-0.023993239,-0.019888287,0.0838974,0.07222716,-0.060099386,0.031007063,-0.0041362504,0.1017514,-0.016920248,0.0030509525,-0.0038674502,-0.10396605,-0.025999775,-0.06901427,-0.016048588,-0.02791482,0.12960415,-0.03325143,-0.0025486592,0.0037388438,0.050290138,-0.04165777,-0.0826633,-0.062149428,-0.061562043,0.06301531,0.099530965,-0.01937101,-0.027761256,0.006320001,0.03325213,0.043769497,-0.017650014,0.0016076299,0.074763626,0.09529537,-0.056379285,-0.10617825,0.045295168,0.022150509,-0.012217726,0.06644658,0.054472484,0.041459635,0.085330315,-0.1267843,1.9473958e-33,0.078971066,0.07502362,0.094360605,-0.03400764,-0.026404945,-0.06849903,-0.094942465,0.05453599,0.02954316,-0.028253786,-0.039869267,-0.04288476,0.077940606,-0.027940022,-0.05409008,-0.02682065,0.0015927695,0.0030903127,0.04249749,-0.039492756,0.009961353,0.033208508,-0.0028744058,0.020358315,-0.0098128505,-0.009339945,0.04868896,-0.0036605555,0.04936724,0.023010671,-0.024276994,-0.056023274,-0.09684596,-0.03167563,0.03126328,0.03815166,-0.07313245,-0.08662732,0.015058772,0.036506508,-0.04083727,0.015762964,0.032497346,-0.06377808,0.020846378,-0.019379282,-0.09054345,0.10961533,0.0077469884,0.05929745,0.056154516,-0.08128941,0.059619404,-0.03778257,-0.06145997,0.04252038,0.024015926,0.005280982,0.07831861,0.038784623,0.05712453,0.023140904,-0.07626847,-0.022322923,-0.016603772,-0.0029377164,-0.023667308,-0.00626565,-0.0038639694,0.099598326,-0.03144555,-0.017679427,0.031857166,0.06263939,-0.010899433,-0.043801945,-0.0333224,0.057189673,0.051150586,-0.011723375,-0.07272043,-0.071866624,-0.004223438,-0.0021336076,-0.050983027,-0.050992195,-0.023344574,0.01815613,-0.06794456,-0.011236661,-0.0076112454,-0.024881499,-0.028343104,0.063313104,-0.03329657,-3.2423833e-33,0.07326735,-0.05304472,0.040597446,-0.10376325,-0.043318607,0.07367136,-0.017133672,0.049101535,0.048382,-0.039173152,0.060118683,-0.036635097,0.05995797,-0.06233396,0.016983798,0.052008703,0.0098938625,0.010604952,0.00956818,0.032017253,0.0032329191,0.09181306,0.046581857,0.0693836,0.056584664,0.014279103,0.02349342,0.08392604,-0.003994979,0.05307386,0.040852938,-0.0014060512,-0.013367504,-0.07654995,-0.048398763,0.06487006,-0.007321133,-0.03209948,0.060475647,-0.008730302,0.0015992981,0.012293901,0.018117847,0.12279487,0.012133329,0.024105646,-0.005703002,-0.009079162,0.019327477,-0.09761358,-0.0066698696,-0.07891222,0.031000828,-0.061040796,-0.028641274,0.101390764,-0.02548811,-0.002796933,-0.061204284,-0.04645218,-0.066516824,-0.060918022,-0.016525546,-0.022040147,-0.0049349093,-0.0018928199,-0.030095967,-0.04800827,0.027676854,-0.03848742,-0.02073594,-0.008167454,-0.0014730794,0.024415884,-0.07970701,-0.04294178,-0.05496154,0.07223783,0.025487833,0.0040053576,-0.03038884,0.014193482,0.007091027,-0.11115262,0.026719693,-0.05850707,0.0043144817,0.10758507,0.0370765,-0.0039662803,-0.07911503,0.00955498,0.003428873,0.04421893,-0.005990361,-4.3751353e-08,0.07920101,-0.07899379,0.058246225,0.008613946,-0.029698383,0.0050143977,-0.022353463,0.018264333,0.0066913487,5.0055576e-05,0.023220098,0.06993705,-0.029678155,0.00044633762,0.023942394,0.02328335,-0.07667012,-0.0069695944,-0.040808283,0.013123043,-0.015843764,-0.05944457,-0.07258739,0.07506729,0.0835454,-0.022510203,0.024287289,-0.014148305,-0.068384826,-0.010265547,0.05013042,0.007940876,-0.016204277,0.012399026,-0.0978225,0.03760678,-0.07288375,-0.056041166,0.018679747,0.066170335,0.055909593,-0.0067265937,-0.104957916,0.032130573,0.020025898,0.024208821,-0.042414054,0.025577107,-0.05608188,-0.02246959,0.03077644,-0.009558968,-0.042478606,0.0041698865,-0.027814008,0.044240184,0.040840425,-0.06490632,0.0514025,-0.05257101,0.048903055,-0.023732431,0.15873303,0.024900822 +1.8.98.7,"A radical S-adenosylmethionine (AdoMet) enzyme that contains three [4Fe-4S] clusters. The enzyme, found in some bacteria, activates a type I sulfatase enzyme (EC 3.1.6.1) by converting a conserved L-cysteine residue in the active site to a unique 3-oxo-L-alanine residue that is essential for the sulfatase activity. Some enzymes can also act on L-serine, see EC 1.1.98.7, serine-type anaerobic sulfatase-maturating enzyme and EC 1.8.3.7, formylglycine-generating enzyme.",384,0.99999994,-0.029562298,-0.09092714,-0.07750745,0.02811354,0.075482674,0.045751456,-0.07656552,0.048368245,0.037491783,-0.035054114,0.009091642,0.017195802,-0.02089571,0.10693424,-0.01939065,0.07292437,-0.116851665,0.021985495,0.035607465,-0.08069605,0.051480856,0.022141786,-0.03235116,-0.0190712,0.026652658,0.03199883,0.039459225,-0.04538431,-0.095566906,-0.020594463,0.009306526,-0.07602015,0.09536345,-0.03878044,0.06838199,0.07725621,-0.0022094275,-0.010666159,0.056204993,0.001442543,0.023129031,0.006672039,0.0067601306,-0.062188257,0.0069170236,-0.046442308,-0.034683857,0.03248844,0.024753464,-0.07758661,-0.062369928,-0.03567813,-0.06286354,0.051893707,0.0007512106,-0.062125195,-0.044071447,-0.017757101,-1.1903095e-05,-0.041794784,0.10403971,-0.0005914589,0.018500088,-0.07377339,0.011493987,-0.029653272,0.07856095,-0.09698204,0.046947,-0.043834917,-0.091142245,-0.029823521,-0.06400993,0.08768285,-0.018959848,0.030564053,-0.024913684,-0.035693146,0.059615873,-0.027718427,0.0352761,-0.017470341,0.014741378,0.08677651,0.04980051,-0.023182277,0.02146379,0.004980037,0.084789604,0.01793504,-0.025238577,-0.05431062,-0.07541062,-0.030153433,-0.047885936,-0.0489386,-0.03985293,0.07742122,-0.016419725,0.016988466,0.013707545,0.05354275,-0.048966855,-0.0640989,-0.012278646,-0.003202879,-0.0061221956,0.08636303,0.004692099,0.027418215,0.000118051874,0.033879176,0.04637883,-0.017728291,-0.021213446,0.11810762,0.04925648,-0.046681657,-0.094357036,0.061320733,0.039143205,0.02583403,0.08061465,0.07116714,0.035915427,0.02729985,-0.15913013,1.0371614e-33,0.08279037,0.048529837,0.106351115,-0.028709637,-0.03789156,-0.057103444,-0.101774685,0.057346087,0.05194754,0.004263106,-0.050977796,-0.050593447,0.11404677,-0.008128075,-0.052772045,-0.061082385,-0.035518963,0.012623346,0.02926828,-0.046651524,-0.060006645,0.04750915,-0.027018132,0.008455256,-0.00017653455,-0.021003554,0.019028433,0.012985938,0.06412857,0.037775747,-0.033290092,-0.09988664,-0.13077648,-0.012053187,0.02054652,0.011576451,-0.053337798,-0.120968774,0.06330079,0.03271442,-0.02675687,0.011594018,0.07049122,-0.07051947,0.04454962,0.0068796687,-0.06317312,0.090287074,0.040057797,0.08228148,0.02490684,-0.08297342,0.08069344,-0.015515842,-0.063248165,0.018339956,0.014949665,-0.0105518205,0.05366718,0.053229306,0.039929677,-0.006845214,-0.08530336,-0.041636895,-0.048064645,0.027606208,-0.019252032,-0.013259579,-0.0031529728,0.09015415,-0.021260645,0.014508527,0.03698355,0.044652294,-0.036755364,-0.04569947,0.014468023,0.05652897,-0.0034493906,-0.02166549,-0.08983495,-0.069602154,-0.038481582,-0.02017391,-0.049423177,-0.010247616,-0.009846133,0.0040275156,-0.046049647,-0.015870525,-0.033583455,-0.001473259,-0.060651667,0.06583359,-0.009981074,-2.1595416e-33,0.068417594,-0.044175997,0.0033470474,-0.08992724,-0.05976537,0.034659296,0.015355434,0.056691136,0.027816365,-0.013861009,0.045542415,-0.01772249,0.06928865,-0.0990499,0.027380593,0.037795763,0.01222289,-0.022568416,0.032159347,0.039401013,0.013915667,0.09604593,0.02463147,0.06752307,0.038585,0.0133226765,-0.008388774,0.06503322,0.038687516,0.067967966,0.02988038,-0.043412644,-0.0043477044,-0.044464674,-0.017770771,0.052469734,0.019676296,-0.005097848,-0.002625571,0.0049374686,-0.0065604863,0.019589582,0.056012593,0.18074954,0.034963097,0.051862076,-0.022774443,0.04714939,-0.010576056,-0.097048484,0.012724627,-0.067055784,0.033449832,-0.027829641,-0.030063163,0.0912,0.0021468163,0.009149177,-0.10602416,0.0056501036,-0.039196666,-0.05494149,0.010723863,-0.03966822,0.0041916408,0.0026570617,-0.0375246,-0.06181266,-0.0016333933,0.011226407,0.013536518,-0.0017928306,0.006443959,0.018315721,-0.06047564,-0.036882244,-0.06455201,0.049236182,0.010157831,-0.02663224,-0.002827576,0.026900472,0.026181871,-0.11197712,0.014838414,-0.06370252,0.005468292,0.13155302,0.028103953,0.022991242,-0.08010012,0.010845049,-0.012178737,0.042303186,-0.023174932,-4.369883e-08,0.043426495,-0.059049074,0.0609682,0.0033360277,-0.020485282,0.020952769,0.00061684346,0.031237764,0.016242709,-8.035989e-06,-0.0047963294,0.08578921,-0.05793896,0.011053622,0.054133598,-0.010554022,-0.06908156,0.03513404,-0.054026183,-0.027561424,-0.03359497,-0.041340664,-0.088729635,0.043437965,0.06310014,0.0018555357,0.04800587,-0.003014271,-0.046187997,0.009141735,0.050909203,0.013286473,-0.02216387,0.0019032961,-0.109706275,0.022005064,-0.08585312,-0.055079103,-0.002159693,0.06596138,0.038121175,4.1145493e-05,-0.08619092,0.03324205,0.03471073,0.037150197,-0.017417548,0.018003507,-0.040525954,-0.0006897005,0.026437117,-0.007901645,-0.0421198,-0.011562383,-0.065247044,0.044812918,-0.011925664,-0.07654652,0.067512386,-0.000114021495,0.056010265,0.0036941995,0.15327354,0.03330685 +1.11.1.25,"Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [2]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Glutaredoxin-dependent peroxiredoxins have been reported from bacteria, fungi, plants, and animals. These enzymes are often able to use an alternative reductant such as thioredoxin or glutathione.",384,1.0,-0.08901404,-0.047284808,-0.063751206,-0.002322031,0.062055234,0.04001235,-0.04163136,0.06396663,0.080528624,-0.016283182,0.021414347,0.061442047,0.043700058,-0.024471976,-0.046463802,0.0985906,-0.074452415,0.050786376,0.009374847,0.06869153,0.022589013,-0.08248714,-0.028370403,-0.0032169602,-0.028810225,0.05330078,0.050685894,0.05656495,-0.053062323,0.010132201,-0.009254353,0.005686765,-0.004577995,-0.040693156,-0.01648206,0.080634944,-0.049774125,-0.061554212,-0.06882031,-0.07032569,-0.0017190375,-0.005853287,-0.045983467,0.02913377,-0.00019510872,-0.023804262,0.055399217,0.0046314197,0.021343809,-0.054453585,0.024666099,-0.06114754,-0.012346983,0.03234192,-0.007743846,0.06434814,-0.13107096,0.053688526,-0.024994409,-0.03738058,-0.04551295,-0.05158601,-0.02882746,-0.012008733,0.013477753,0.002934085,0.048424155,-0.0464448,-0.046644054,-0.08123339,-0.04032445,0.023913087,0.054864705,0.012227396,0.038578626,0.105980106,-0.03268012,-0.04069766,-0.04845375,-0.056390814,0.015373007,0.030788628,0.05054892,0.16971563,0.07956098,-0.059492577,0.02229238,-0.03920079,-0.00095436716,0.048242953,-0.029291803,0.03618508,-0.038894016,0.015127152,-0.016747484,0.04155693,-0.010024786,0.068991445,0.02540342,-0.0341626,-0.0076590134,0.07415589,-0.006078985,-0.1072318,0.026603896,-0.0068654083,-0.07205417,0.058101192,0.009616648,-0.03765594,0.0023486237,0.012487927,0.01535906,-0.017110115,0.020586817,0.08041421,0.019118477,0.0062071453,0.038592223,-0.051037166,-0.01679006,0.02869253,-0.04146898,0.021344662,-0.0071021407,0.014092676,-0.0679869,6.757868e-33,-0.002451707,0.044847544,0.033284534,0.053210024,-0.00053374737,0.009591292,-0.07930417,-0.017371817,0.02404515,0.080088556,-0.08479733,-0.03449356,0.07041286,-0.019096585,-0.033509426,-0.054725688,-0.015057169,-0.06216521,0.040359147,-0.012472298,0.0063344417,0.051751003,-0.023957862,-0.03930226,0.026173228,0.07556865,0.039954856,-0.026013125,-0.039126564,-0.014137734,-0.004177575,-0.024200683,-0.037409354,-0.061203044,0.0074349483,-0.0121825235,0.012184393,0.014602988,-0.010805901,0.014314549,-0.048596464,-0.012045388,-0.01709789,-0.07120247,0.114205,-0.14821704,-0.08029014,0.113950945,0.014068138,0.039962966,0.072205484,-0.05428712,0.08999627,0.018272333,-0.10122436,-0.035024393,0.022032151,0.012840065,0.013532892,0.077342354,0.017817425,0.036774132,-0.07488467,-0.0056479694,0.030247297,0.07357013,-0.110386916,-0.062369864,-0.055601455,0.06388244,-0.019031234,0.060125373,0.027720213,-0.049938783,0.026991282,-0.00558967,-0.024970502,0.14860132,0.12022288,0.07082909,-0.06377533,-0.0075352965,-0.058094822,0.03289374,-0.073974915,-0.005949002,-0.016263887,-0.014109307,-0.031339098,0.047689762,0.09542335,-0.0777227,-0.045724608,-0.0019994152,-0.033837248,-7.7238545e-33,-0.007589764,-0.037617933,0.0044313394,-0.10235114,0.05590572,0.06278947,-0.0014884316,0.029721953,0.048339896,-0.057467487,0.057999395,0.012483525,-0.029944291,-0.014835821,-0.022256328,0.034778316,-0.06031989,0.07057855,-0.055946283,-0.0025966724,0.0240258,0.109807566,0.055713948,0.12277633,0.05144397,-0.03781712,0.04742008,0.05550312,0.05412888,0.11911857,-0.03331611,-0.005009495,-0.019525941,0.008940117,0.022701986,0.023599748,-0.12667792,0.026669996,0.064503506,0.004236509,0.016705474,-0.043744788,-0.06351521,0.089576416,0.061664924,0.10968199,-0.08385328,-0.011467811,0.0035608083,-0.029378489,-0.006927973,0.019180551,0.028467359,0.01197101,0.042953618,-0.019302987,-0.060964152,-0.038530607,0.076353826,-0.015148213,-0.05424184,-0.03330837,0.019012516,0.048258103,-0.026650522,-0.0012180251,-0.05616037,-0.0057172016,0.049862422,-0.031226879,0.030297838,0.02886035,-0.050483275,-0.038965296,-0.025102502,-0.027525852,-0.035910904,0.044631172,0.034303695,0.035969373,-0.00888836,-0.002854907,-0.013551752,-0.04200608,0.019038247,0.027698718,0.034726653,0.05284016,0.05350084,-0.06813016,0.011735141,0.07852912,-0.03422594,0.039449587,0.04732105,-5.2888563e-08,0.01735202,-0.061623275,0.049732793,-0.020724563,-0.013799929,0.014323218,-0.012209145,0.07539393,-0.02389319,-0.04071066,0.053208034,0.12829055,-0.02980062,-0.086042844,-0.02759459,0.008028288,0.01669241,0.005049181,-0.013038188,-0.040742043,-0.06559228,-0.055243947,-0.051271886,0.036895335,0.012593702,-0.08887814,0.02307265,-0.09187629,-0.020056464,-0.0319408,0.081094585,-0.027708424,-0.08262271,-0.0041492423,-0.08224677,0.081316724,0.028207958,0.036773875,0.040802535,-0.07660657,-0.088038415,-0.078355014,-0.06681194,-0.0013198331,-0.004061937,0.017815946,0.036225595,-0.0036241813,0.021351742,-0.025128193,0.014465046,-0.027284734,-0.04707934,-0.08228413,-0.121528536,0.045761533,0.027914988,-0.010441373,0.016658543,-0.082352154,-0.041177567,0.05477421,0.067649595,0.008468368 +1.11.1.26,"Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. This bacterial peroxiredoxin differs from most other forms by comprising two types of subunits. One subunit (AhpC) is a typical 2-Cys peroxiredoxin. Following the reduction of the substrate, one AhpC subunit forms a disulfide bond with an identical unit. The disulfide bond is reduced by the second type of subunit (AhpF). This second subunit is a flavin-containing protein that uses electrons from NADH to reduce the cysteine residues on the AhpC subunits back to their active state.",384,1.0,-0.08940976,-0.0470719,-0.06363992,-0.0018671062,0.061819766,0.0398221,-0.04100343,0.06398028,0.08086889,-0.016271211,0.02102028,0.061593246,0.044051494,-0.02415238,-0.047101412,0.098115616,-0.0740505,0.049897917,0.009363607,0.06915693,0.021539247,-0.08257491,-0.028792944,-0.0027226384,-0.02840928,0.053184174,0.051213462,0.056519534,-0.053311728,0.009892145,-0.009323959,0.006035002,-0.0041272184,-0.04085882,-0.016124478,0.08098205,-0.049059436,-0.062620886,-0.06834728,-0.0701179,-0.001511706,-0.0053619896,-0.046034917,0.028698878,-0.00100663,-0.023900928,0.054911982,0.005292196,0.021656003,-0.0544735,0.025466757,-0.061327398,-0.011956181,0.032164082,-0.007870957,0.064096466,-0.13108566,0.053472225,-0.024972318,-0.038091943,-0.04593426,-0.051714383,-0.028370842,-0.012052787,0.013196444,0.0027838224,0.04816354,-0.046645332,-0.046711136,-0.08144081,-0.040481847,0.02394573,0.05489048,0.012269913,0.038257964,0.1063921,-0.03239738,-0.041025553,-0.04823245,-0.05594636,0.015810987,0.030887233,0.05044967,0.16980274,0.07973731,-0.059339285,0.022847347,-0.038711216,-0.00044194903,0.047982153,-0.029347992,0.036036957,-0.039194573,0.014968869,-0.016348077,0.041137084,-0.00996909,0.06964722,0.024745787,-0.034018308,-0.007840639,0.07428657,-0.0060084127,-0.10741893,0.026650522,-0.0063239457,-0.072037615,0.0589874,0.009508838,-0.037603427,0.002186528,0.011933831,0.015616423,-0.017080676,0.020291125,0.07983404,0.018526722,0.0059635295,0.038132925,-0.05155134,-0.016739866,0.029123623,-0.041589107,0.02190552,-0.0075520067,0.014579349,-0.06792815,6.837305e-33,-0.0022986296,0.045009922,0.033416703,0.052351795,-0.00065589487,0.009230906,-0.07926393,-0.017298693,0.02385292,0.08028396,-0.085236415,-0.03355962,0.07010098,-0.0199894,-0.03394316,-0.054500006,-0.015605089,-0.06276259,0.03995914,-0.012447076,0.00567912,0.051537715,-0.023869932,-0.039443035,0.025738603,0.075314775,0.039154064,-0.026029395,-0.03905872,-0.014513569,-0.004747773,-0.024071366,-0.037449017,-0.06171733,0.0073841866,-0.011676576,0.012425131,0.014228205,-0.010959474,0.014373529,-0.048330132,-0.011902786,-0.017689401,-0.07173694,0.113586314,-0.14819053,-0.08055771,0.11385924,0.014329712,0.039937835,0.07210566,-0.054343898,0.089998074,0.017603254,-0.101710245,-0.034854233,0.022368513,0.012652894,0.01387664,0.07727131,0.017801821,0.036318038,-0.07478959,-0.0060222563,0.030135173,0.07345045,-0.10992354,-0.06220917,-0.0556581,0.06333362,-0.019082988,0.06020365,0.027130406,-0.050552115,0.027185647,-0.0055453205,-0.024837751,0.14854996,0.12009218,0.07126767,-0.06320816,-0.00769086,-0.05810335,0.032842815,-0.073728286,-0.005455867,-0.015817655,-0.013963463,-0.031348716,0.04756306,0.096264236,-0.07802041,-0.045355666,-0.0018842883,-0.03463991,-7.792714e-33,-0.0076348414,-0.038099535,0.0045086467,-0.10237083,0.05577805,0.0630811,-0.00190057,0.029830638,0.0482235,-0.057891265,0.05822748,0.012101414,-0.030683914,-0.014904437,-0.021580728,0.034866016,-0.059766494,0.07027829,-0.05590353,-0.0029194746,0.023510434,0.10951211,0.0555498,0.12297277,0.051218364,-0.03750199,0.04786112,0.055493202,0.054390382,0.119356215,-0.032908984,-0.0045375424,-0.019416396,0.008835812,0.022478413,0.023853429,-0.12702087,0.026968734,0.06537628,0.0041476307,0.016676812,-0.043785717,-0.06369169,0.08958767,0.06202556,0.10994119,-0.084314756,-0.011330876,0.0039963983,-0.029052166,-0.00681427,0.020295419,0.02834611,0.01179305,0.042948276,-0.019466123,-0.061324205,-0.03835225,0.07648735,-0.015855508,-0.05406286,-0.03334583,0.018914154,0.048464533,-0.026320329,-0.00053779717,-0.055774983,-0.0060037044,0.050218973,-0.03174718,0.031203436,0.029161157,-0.050285857,-0.038937375,-0.024488727,-0.027084542,-0.036237113,0.044575207,0.03409249,0.03608211,-0.008577363,-0.0023732302,-0.013983483,-0.042407293,0.01945415,0.028509943,0.034793086,0.05294231,0.05372631,-0.06760578,0.011788011,0.07817529,-0.03420379,0.039330296,0.047633525,-5.306895e-08,0.017400336,-0.06115368,0.04897379,-0.020623311,-0.013910553,0.014832052,-0.011782691,0.074665,-0.023507573,-0.040710483,0.053529065,0.12827353,-0.029911643,-0.08590933,-0.028010039,0.008152428,0.015761279,0.0047434745,-0.012715012,-0.04010081,-0.06569096,-0.05477027,-0.051150877,0.036462117,0.012207078,-0.089050494,0.023182794,-0.09110285,-0.020306928,-0.03211114,0.080913305,-0.027251096,-0.08253162,-0.004358331,-0.08204162,0.0814253,0.02813295,0.03754319,0.041084837,-0.0767436,-0.088517755,-0.077945985,-0.066429175,-0.002000841,-0.0044124057,0.01828867,0.03654828,-0.0031061699,0.02143655,-0.025432436,0.0146585945,-0.026889319,-0.047111426,-0.08270667,-0.12143737,0.04526622,0.027467694,-0.00991382,0.017152116,-0.082213596,-0.042193282,0.054084267,0.06730748,0.008535095 +1.11.1.27,"Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Glutathione-dependent peroxiredoxins have been reported from bacteria and animals, and appear to be 1-Cys enzymes. The mechanism for the mammalian PRDX6 enzyme involves heterodimerization of the enzyme with pi-glutathione S-transferase, followed by glutathionylation of the oxidized cysteine residue. Subsequent dissociation of the heterodimer yields glutathionylated peroxiredoxin, which is restored to the active form via spontaneous reduction by a second glutathione molecule.",384,1.0,-0.08940976,-0.0470719,-0.06363992,-0.0018671062,0.061819766,0.0398221,-0.04100343,0.06398028,0.08086889,-0.016271211,0.02102028,0.061593246,0.044051494,-0.02415238,-0.047101412,0.098115616,-0.0740505,0.049897917,0.009363607,0.06915693,0.021539247,-0.08257491,-0.028792944,-0.0027226384,-0.02840928,0.053184174,0.051213462,0.056519534,-0.053311728,0.009892145,-0.009323959,0.006035002,-0.0041272184,-0.04085882,-0.016124478,0.08098205,-0.049059436,-0.062620886,-0.06834728,-0.0701179,-0.001511706,-0.0053619896,-0.046034917,0.028698878,-0.00100663,-0.023900928,0.054911982,0.005292196,0.021656003,-0.0544735,0.025466757,-0.061327398,-0.011956181,0.032164082,-0.007870957,0.064096466,-0.13108566,0.053472225,-0.024972318,-0.038091943,-0.04593426,-0.051714383,-0.028370842,-0.012052787,0.013196444,0.0027838224,0.04816354,-0.046645332,-0.046711136,-0.08144081,-0.040481847,0.02394573,0.05489048,0.012269913,0.038257964,0.1063921,-0.03239738,-0.041025553,-0.04823245,-0.05594636,0.015810987,0.030887233,0.05044967,0.16980274,0.07973731,-0.059339285,0.022847347,-0.038711216,-0.00044194903,0.047982153,-0.029347992,0.036036957,-0.039194573,0.014968869,-0.016348077,0.041137084,-0.00996909,0.06964722,0.024745787,-0.034018308,-0.007840639,0.07428657,-0.0060084127,-0.10741893,0.026650522,-0.0063239457,-0.072037615,0.0589874,0.009508838,-0.037603427,0.002186528,0.011933831,0.015616423,-0.017080676,0.020291125,0.07983404,0.018526722,0.0059635295,0.038132925,-0.05155134,-0.016739866,0.029123623,-0.041589107,0.02190552,-0.0075520067,0.014579349,-0.06792815,6.837305e-33,-0.0022986296,0.045009922,0.033416703,0.052351795,-0.00065589487,0.009230906,-0.07926393,-0.017298693,0.02385292,0.08028396,-0.085236415,-0.03355962,0.07010098,-0.0199894,-0.03394316,-0.054500006,-0.015605089,-0.06276259,0.03995914,-0.012447076,0.00567912,0.051537715,-0.023869932,-0.039443035,0.025738603,0.075314775,0.039154064,-0.026029395,-0.03905872,-0.014513569,-0.004747773,-0.024071366,-0.037449017,-0.06171733,0.0073841866,-0.011676576,0.012425131,0.014228205,-0.010959474,0.014373529,-0.048330132,-0.011902786,-0.017689401,-0.07173694,0.113586314,-0.14819053,-0.08055771,0.11385924,0.014329712,0.039937835,0.07210566,-0.054343898,0.089998074,0.017603254,-0.101710245,-0.034854233,0.022368513,0.012652894,0.01387664,0.07727131,0.017801821,0.036318038,-0.07478959,-0.0060222563,0.030135173,0.07345045,-0.10992354,-0.06220917,-0.0556581,0.06333362,-0.019082988,0.06020365,0.027130406,-0.050552115,0.027185647,-0.0055453205,-0.024837751,0.14854996,0.12009218,0.07126767,-0.06320816,-0.00769086,-0.05810335,0.032842815,-0.073728286,-0.005455867,-0.015817655,-0.013963463,-0.031348716,0.04756306,0.096264236,-0.07802041,-0.045355666,-0.0018842883,-0.03463991,-7.792714e-33,-0.0076348414,-0.038099535,0.0045086467,-0.10237083,0.05577805,0.0630811,-0.00190057,0.029830638,0.0482235,-0.057891265,0.05822748,0.012101414,-0.030683914,-0.014904437,-0.021580728,0.034866016,-0.059766494,0.07027829,-0.05590353,-0.0029194746,0.023510434,0.10951211,0.0555498,0.12297277,0.051218364,-0.03750199,0.04786112,0.055493202,0.054390382,0.119356215,-0.032908984,-0.0045375424,-0.019416396,0.008835812,0.022478413,0.023853429,-0.12702087,0.026968734,0.06537628,0.0041476307,0.016676812,-0.043785717,-0.06369169,0.08958767,0.06202556,0.10994119,-0.084314756,-0.011330876,0.0039963983,-0.029052166,-0.00681427,0.020295419,0.02834611,0.01179305,0.042948276,-0.019466123,-0.061324205,-0.03835225,0.07648735,-0.015855508,-0.05406286,-0.03334583,0.018914154,0.048464533,-0.026320329,-0.00053779717,-0.055774983,-0.0060037044,0.050218973,-0.03174718,0.031203436,0.029161157,-0.050285857,-0.038937375,-0.024488727,-0.027084542,-0.036237113,0.044575207,0.03409249,0.03608211,-0.008577363,-0.0023732302,-0.013983483,-0.042407293,0.01945415,0.028509943,0.034793086,0.05294231,0.05372631,-0.06760578,0.011788011,0.07817529,-0.03420379,0.039330296,0.047633525,-5.306895e-08,0.017400336,-0.06115368,0.04897379,-0.020623311,-0.013910553,0.014832052,-0.011782691,0.074665,-0.023507573,-0.040710483,0.053529065,0.12827353,-0.029911643,-0.08590933,-0.028010039,0.008152428,0.015761279,0.0047434745,-0.012715012,-0.04010081,-0.06569096,-0.05477027,-0.051150877,0.036462117,0.012207078,-0.089050494,0.023182794,-0.09110285,-0.020306928,-0.03211114,0.080913305,-0.027251096,-0.08253162,-0.004358331,-0.08204162,0.0814253,0.02813295,0.03754319,0.041084837,-0.0767436,-0.088517755,-0.077945985,-0.066429175,-0.002000841,-0.0044124057,0.01828867,0.03654828,-0.0031061699,0.02143655,-0.025432436,0.0146585945,-0.026889319,-0.047111426,-0.08270667,-0.12143737,0.04526622,0.027467694,-0.00991382,0.017152116,-0.082213596,-0.042193282,0.054084267,0.06730748,0.008535095 +1.11.1.28,"Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [2]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Two types of lipoyl-dependent peroxiredoxins have been reported from bacteria. One type is the AhpC/AhpD system, originally described from Mycobacterium tuberculosis. In that system, AhpC catalyses reduction of the substrate, resulting in an intramolecular disulfide. AhpD then forms an intermolecular disulfide crosslink with AhpC, reducing it back to active state. AhpD is reduced in turn by lipoylated proteins. The second type, which has been characterized in Xylella fastidiosa, consists of only one type of subunit, which interacts directly with lipoylated proteins.",384,1.0,-0.08901404,-0.047284808,-0.063751206,-0.002322031,0.062055234,0.04001235,-0.04163136,0.06396663,0.080528624,-0.016283182,0.021414347,0.061442047,0.043700058,-0.024471976,-0.046463802,0.0985906,-0.074452415,0.050786376,0.009374847,0.06869153,0.022589013,-0.08248714,-0.028370403,-0.0032169602,-0.028810225,0.05330078,0.050685894,0.05656495,-0.053062323,0.010132201,-0.009254353,0.005686765,-0.004577995,-0.040693156,-0.01648206,0.080634944,-0.049774125,-0.061554212,-0.06882031,-0.07032569,-0.0017190375,-0.005853287,-0.045983467,0.02913377,-0.00019510872,-0.023804262,0.055399217,0.0046314197,0.021343809,-0.054453585,0.024666099,-0.06114754,-0.012346983,0.03234192,-0.007743846,0.06434814,-0.13107096,0.053688526,-0.024994409,-0.03738058,-0.04551295,-0.05158601,-0.02882746,-0.012008733,0.013477753,0.002934085,0.048424155,-0.0464448,-0.046644054,-0.08123339,-0.04032445,0.023913087,0.054864705,0.012227396,0.038578626,0.105980106,-0.03268012,-0.04069766,-0.04845375,-0.056390814,0.015373007,0.030788628,0.05054892,0.16971563,0.07956098,-0.059492577,0.02229238,-0.03920079,-0.00095436716,0.048242953,-0.029291803,0.03618508,-0.038894016,0.015127152,-0.016747484,0.04155693,-0.010024786,0.068991445,0.02540342,-0.0341626,-0.0076590134,0.07415589,-0.006078985,-0.1072318,0.026603896,-0.0068654083,-0.07205417,0.058101192,0.009616648,-0.03765594,0.0023486237,0.012487927,0.01535906,-0.017110115,0.020586817,0.08041421,0.019118477,0.0062071453,0.038592223,-0.051037166,-0.01679006,0.02869253,-0.04146898,0.021344662,-0.0071021407,0.014092676,-0.0679869,6.757868e-33,-0.002451707,0.044847544,0.033284534,0.053210024,-0.00053374737,0.009591292,-0.07930417,-0.017371817,0.02404515,0.080088556,-0.08479733,-0.03449356,0.07041286,-0.019096585,-0.033509426,-0.054725688,-0.015057169,-0.06216521,0.040359147,-0.012472298,0.0063344417,0.051751003,-0.023957862,-0.03930226,0.026173228,0.07556865,0.039954856,-0.026013125,-0.039126564,-0.014137734,-0.004177575,-0.024200683,-0.037409354,-0.061203044,0.0074349483,-0.0121825235,0.012184393,0.014602988,-0.010805901,0.014314549,-0.048596464,-0.012045388,-0.01709789,-0.07120247,0.114205,-0.14821704,-0.08029014,0.113950945,0.014068138,0.039962966,0.072205484,-0.05428712,0.08999627,0.018272333,-0.10122436,-0.035024393,0.022032151,0.012840065,0.013532892,0.077342354,0.017817425,0.036774132,-0.07488467,-0.0056479694,0.030247297,0.07357013,-0.110386916,-0.062369864,-0.055601455,0.06388244,-0.019031234,0.060125373,0.027720213,-0.049938783,0.026991282,-0.00558967,-0.024970502,0.14860132,0.12022288,0.07082909,-0.06377533,-0.0075352965,-0.058094822,0.03289374,-0.073974915,-0.005949002,-0.016263887,-0.014109307,-0.031339098,0.047689762,0.09542335,-0.0777227,-0.045724608,-0.0019994152,-0.033837248,-7.7238545e-33,-0.007589764,-0.037617933,0.0044313394,-0.10235114,0.05590572,0.06278947,-0.0014884316,0.029721953,0.048339896,-0.057467487,0.057999395,0.012483525,-0.029944291,-0.014835821,-0.022256328,0.034778316,-0.06031989,0.07057855,-0.055946283,-0.0025966724,0.0240258,0.109807566,0.055713948,0.12277633,0.05144397,-0.03781712,0.04742008,0.05550312,0.05412888,0.11911857,-0.03331611,-0.005009495,-0.019525941,0.008940117,0.022701986,0.023599748,-0.12667792,0.026669996,0.064503506,0.004236509,0.016705474,-0.043744788,-0.06351521,0.089576416,0.061664924,0.10968199,-0.08385328,-0.011467811,0.0035608083,-0.029378489,-0.006927973,0.019180551,0.028467359,0.01197101,0.042953618,-0.019302987,-0.060964152,-0.038530607,0.076353826,-0.015148213,-0.05424184,-0.03330837,0.019012516,0.048258103,-0.026650522,-0.0012180251,-0.05616037,-0.0057172016,0.049862422,-0.031226879,0.030297838,0.02886035,-0.050483275,-0.038965296,-0.025102502,-0.027525852,-0.035910904,0.044631172,0.034303695,0.035969373,-0.00888836,-0.002854907,-0.013551752,-0.04200608,0.019038247,0.027698718,0.034726653,0.05284016,0.05350084,-0.06813016,0.011735141,0.07852912,-0.03422594,0.039449587,0.04732105,-5.2888563e-08,0.01735202,-0.061623275,0.049732793,-0.020724563,-0.013799929,0.014323218,-0.012209145,0.07539393,-0.02389319,-0.04071066,0.053208034,0.12829055,-0.02980062,-0.086042844,-0.02759459,0.008028288,0.01669241,0.005049181,-0.013038188,-0.040742043,-0.06559228,-0.055243947,-0.051271886,0.036895335,0.012593702,-0.08887814,0.02307265,-0.09187629,-0.020056464,-0.0319408,0.081094585,-0.027708424,-0.08262271,-0.0041492423,-0.08224677,0.081316724,0.028207958,0.036773875,0.040802535,-0.07660657,-0.088038415,-0.078355014,-0.06681194,-0.0013198331,-0.004061937,0.017815946,0.036225595,-0.0036241813,0.021351742,-0.025128193,0.014465046,-0.027284734,-0.04707934,-0.08228413,-0.121528536,0.045761533,0.027914988,-0.010441373,0.016658543,-0.082352154,-0.041177567,0.05477421,0.067649595,0.008468368 +1.11.1.29,"Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Mycoredoxin-dependent enzymes are found in Mycobacteria. Following the reduction of the substrate, the sulfenic acid derivative of the peroxidatic cysteine forms a protein mixed disulfide with the N-terminal cysteine of mycoredoxin, which is then reduced by the C-terminal cysteine of mycoredoxin, restoring the peroxiredoxin to active state and resulting in an intra-protein disulfide in mycoredoxin. The disulfide is eventually reduced by mycothiol.",384,1.0,-0.08940976,-0.0470719,-0.06363992,-0.0018671062,0.061819766,0.0398221,-0.04100343,0.06398028,0.08086889,-0.016271211,0.02102028,0.061593246,0.044051494,-0.02415238,-0.047101412,0.098115616,-0.0740505,0.049897917,0.009363607,0.06915693,0.021539247,-0.08257491,-0.028792944,-0.0027226384,-0.02840928,0.053184174,0.051213462,0.056519534,-0.053311728,0.009892145,-0.009323959,0.006035002,-0.0041272184,-0.04085882,-0.016124478,0.08098205,-0.049059436,-0.062620886,-0.06834728,-0.0701179,-0.001511706,-0.0053619896,-0.046034917,0.028698878,-0.00100663,-0.023900928,0.054911982,0.005292196,0.021656003,-0.0544735,0.025466757,-0.061327398,-0.011956181,0.032164082,-0.007870957,0.064096466,-0.13108566,0.053472225,-0.024972318,-0.038091943,-0.04593426,-0.051714383,-0.028370842,-0.012052787,0.013196444,0.0027838224,0.04816354,-0.046645332,-0.046711136,-0.08144081,-0.040481847,0.02394573,0.05489048,0.012269913,0.038257964,0.1063921,-0.03239738,-0.041025553,-0.04823245,-0.05594636,0.015810987,0.030887233,0.05044967,0.16980274,0.07973731,-0.059339285,0.022847347,-0.038711216,-0.00044194903,0.047982153,-0.029347992,0.036036957,-0.039194573,0.014968869,-0.016348077,0.041137084,-0.00996909,0.06964722,0.024745787,-0.034018308,-0.007840639,0.07428657,-0.0060084127,-0.10741893,0.026650522,-0.0063239457,-0.072037615,0.0589874,0.009508838,-0.037603427,0.002186528,0.011933831,0.015616423,-0.017080676,0.020291125,0.07983404,0.018526722,0.0059635295,0.038132925,-0.05155134,-0.016739866,0.029123623,-0.041589107,0.02190552,-0.0075520067,0.014579349,-0.06792815,6.837305e-33,-0.0022986296,0.045009922,0.033416703,0.052351795,-0.00065589487,0.009230906,-0.07926393,-0.017298693,0.02385292,0.08028396,-0.085236415,-0.03355962,0.07010098,-0.0199894,-0.03394316,-0.054500006,-0.015605089,-0.06276259,0.03995914,-0.012447076,0.00567912,0.051537715,-0.023869932,-0.039443035,0.025738603,0.075314775,0.039154064,-0.026029395,-0.03905872,-0.014513569,-0.004747773,-0.024071366,-0.037449017,-0.06171733,0.0073841866,-0.011676576,0.012425131,0.014228205,-0.010959474,0.014373529,-0.048330132,-0.011902786,-0.017689401,-0.07173694,0.113586314,-0.14819053,-0.08055771,0.11385924,0.014329712,0.039937835,0.07210566,-0.054343898,0.089998074,0.017603254,-0.101710245,-0.034854233,0.022368513,0.012652894,0.01387664,0.07727131,0.017801821,0.036318038,-0.07478959,-0.0060222563,0.030135173,0.07345045,-0.10992354,-0.06220917,-0.0556581,0.06333362,-0.019082988,0.06020365,0.027130406,-0.050552115,0.027185647,-0.0055453205,-0.024837751,0.14854996,0.12009218,0.07126767,-0.06320816,-0.00769086,-0.05810335,0.032842815,-0.073728286,-0.005455867,-0.015817655,-0.013963463,-0.031348716,0.04756306,0.096264236,-0.07802041,-0.045355666,-0.0018842883,-0.03463991,-7.792714e-33,-0.0076348414,-0.038099535,0.0045086467,-0.10237083,0.05577805,0.0630811,-0.00190057,0.029830638,0.0482235,-0.057891265,0.05822748,0.012101414,-0.030683914,-0.014904437,-0.021580728,0.034866016,-0.059766494,0.07027829,-0.05590353,-0.0029194746,0.023510434,0.10951211,0.0555498,0.12297277,0.051218364,-0.03750199,0.04786112,0.055493202,0.054390382,0.119356215,-0.032908984,-0.0045375424,-0.019416396,0.008835812,0.022478413,0.023853429,-0.12702087,0.026968734,0.06537628,0.0041476307,0.016676812,-0.043785717,-0.06369169,0.08958767,0.06202556,0.10994119,-0.084314756,-0.011330876,0.0039963983,-0.029052166,-0.00681427,0.020295419,0.02834611,0.01179305,0.042948276,-0.019466123,-0.061324205,-0.03835225,0.07648735,-0.015855508,-0.05406286,-0.03334583,0.018914154,0.048464533,-0.026320329,-0.00053779717,-0.055774983,-0.0060037044,0.050218973,-0.03174718,0.031203436,0.029161157,-0.050285857,-0.038937375,-0.024488727,-0.027084542,-0.036237113,0.044575207,0.03409249,0.03608211,-0.008577363,-0.0023732302,-0.013983483,-0.042407293,0.01945415,0.028509943,0.034793086,0.05294231,0.05372631,-0.06760578,0.011788011,0.07817529,-0.03420379,0.039330296,0.047633525,-5.306895e-08,0.017400336,-0.06115368,0.04897379,-0.020623311,-0.013910553,0.014832052,-0.011782691,0.074665,-0.023507573,-0.040710483,0.053529065,0.12827353,-0.029911643,-0.08590933,-0.028010039,0.008152428,0.015761279,0.0047434745,-0.012715012,-0.04010081,-0.06569096,-0.05477027,-0.051150877,0.036462117,0.012207078,-0.089050494,0.023182794,-0.09110285,-0.020306928,-0.03211114,0.080913305,-0.027251096,-0.08253162,-0.004358331,-0.08204162,0.0814253,0.02813295,0.03754319,0.041084837,-0.0767436,-0.088517755,-0.077945985,-0.066429175,-0.002000841,-0.0044124057,0.01828867,0.03654828,-0.0031061699,0.02143655,-0.025432436,0.0146585945,-0.026889319,-0.047111426,-0.08270667,-0.12143737,0.04526622,0.027467694,-0.00991382,0.017152116,-0.082213596,-0.042193282,0.054084267,0.06730748,0.008535095 +1.14.18.12,"Requires iron(II). The enzyme, characterized from yeast, is involved in phytosphingosine metabolism. The reaction is mediated by iron(IV) peroxide and results in the release of a water molecule and a carbon dioxide molecule, shortening the substrate by a single carbon atom and forming an odd-numbered fatty acid. Both oxygen atoms of the original carboxylate group are released - one as the leaving water molecule, the other as one of the oxygens of the carbon dioxide molecule. The two oxygen atoms in the newly-formed carboxylate originate from the 2-hydroxy group and from molecular oxygen, respectively. The other oxygen atom of the molecular oxygen is incorporated into the leaving CO2 molecule. The enzyme from the yeast Saccharomyces cerevisiae is active at least toward C14 to C26 2-hydroxyfatty acids, but not against C8 2-hydroxyfatty acid.",384,1.0,-0.0020432037,-0.050467126,-0.06007858,0.04725465,0.08023027,0.02952539,-0.0768683,0.03265872,0.022787923,-0.03511132,-0.027220607,-0.03331798,-0.13107824,-0.02988581,-0.055784773,0.013317378,-0.012413991,-0.00734326,-0.006357417,-0.022967733,0.079776786,-0.00036215896,0.012442018,-0.007928862,-0.01388276,-0.05148146,0.048122875,-0.021651046,-0.0116944155,-0.06127364,0.036802087,-0.09510886,0.021805428,-0.03590709,-0.025873207,0.039416004,0.05198116,-0.10870888,-0.014893629,-0.0037505499,-0.0370934,-0.026956374,-0.08842462,0.047195036,-0.0106677795,-0.003617174,0.0652843,0.014999363,-0.020068854,-0.045957677,-0.040060632,-0.054119892,-0.07961693,0.013827558,-0.10327546,0.042777035,-0.021633007,0.0034355843,0.0047848313,-0.012530755,-0.017571736,-0.034670763,0.017958155,0.03276994,0.00041250428,-0.0475161,0.06674308,-0.0068548652,-0.022571282,-0.019511033,-0.057086628,0.008947441,-0.033373833,-0.028032202,0.0014455084,0.030948061,0.040190753,-0.10318691,0.09836146,0.007453282,0.020800285,0.02347507,0.060209274,0.047211304,0.045750275,-0.011324379,0.026537534,0.06859069,0.0060591823,0.047811035,-0.027093092,0.04956551,0.0047801007,0.06432494,-0.011818205,0.03079276,0.090115495,0.075332806,0.043112073,-0.038013868,0.006471967,0.08885967,0.011904494,-0.066580296,0.05890918,0.041919593,0.014575117,0.12033599,0.058553744,0.08453164,0.037302822,-0.024031464,0.03268655,0.0050695087,0.024473803,0.08354055,0.021380825,0.008314567,-0.04756748,0.010044724,0.025294498,0.02533796,-0.0020840156,-0.030042592,-0.103640504,-0.008004143,-0.09755453,2.5148438e-33,0.011287217,0.010399539,-0.045273393,0.06247678,-0.015279095,-0.037257973,-0.14399499,-0.023202052,-0.056984343,0.031272102,-0.0640906,-0.027282871,-0.014536184,0.04434232,-0.014574113,-0.05454646,0.02558931,-0.007059785,0.067942016,0.018635469,0.0020454838,0.05451509,-0.039063454,0.016811682,0.08348762,0.06880471,-0.028857298,0.03796656,-0.034873165,-0.030631594,0.014002057,-0.101985514,-0.07167167,0.014520366,0.12740432,-0.028032295,0.029231433,-0.025974419,-0.03574376,0.018751161,0.025160119,0.034265593,-0.02250922,-0.052367676,0.06265447,-0.10322767,-0.027000178,0.079232216,0.058519367,0.06635264,-0.018080605,0.0092906095,0.112320624,0.06525319,-0.051609855,-0.011427685,-0.051676217,0.003170346,0.06548814,0.025531009,-0.06604995,0.1118447,0.019577954,0.07329872,-0.011327293,0.0016079339,-0.13220648,-0.0018107069,-0.03730994,0.05236874,-0.032478467,0.021408303,0.048922382,0.008839483,0.039860968,-0.06646677,-0.03982241,-0.039145924,-0.009774156,0.036402993,0.04485016,-0.03395201,-0.024094863,-0.063638456,-0.07917191,0.04234149,-0.032168835,0.019347196,-0.00017124659,0.007929388,0.008510156,-0.082780346,0.033383,-0.04078289,0.05303875,-4.245742e-33,0.109044045,-0.026436757,0.056148957,-0.10957201,-0.011704628,0.117172904,0.035390593,-0.11992361,0.006011684,-0.04769171,0.00083414407,-0.05208488,0.022765948,-0.021921305,0.019745985,0.01869989,-0.05990295,0.07173705,-0.021050854,-0.025394509,0.010421167,0.11359869,-0.0013225186,0.09694082,0.10742554,-0.01755091,-0.021684855,0.05543921,0.026879104,0.04179137,0.00804144,-0.011894033,0.028197616,-0.028811373,-0.019794486,0.026043901,-0.07501568,0.022949895,0.015814904,0.11013315,0.035279576,-0.022438452,-0.056524612,0.066016935,0.01284818,0.085307576,-0.06372378,-0.034065656,0.033737056,-0.03465254,0.010451694,-0.014148071,-0.09125464,0.03338047,0.11333711,0.042610813,0.012367865,0.018403156,0.0074716,-0.03995343,0.004419162,-0.07196032,0.048231587,-0.048929002,0.028688338,-0.015287176,-0.063575104,0.049480863,0.024746854,-0.031770576,0.031031137,0.05753418,0.049235098,0.012575169,-0.029378617,-0.0066093383,-0.06114887,-0.08451104,-0.044591863,-0.040636446,-0.011362302,-0.008353829,0.118588254,-0.03855972,0.002043715,-0.089268826,0.004534693,-0.017180692,-0.054944854,0.018086866,-0.0032391541,-0.005184944,-0.021669831,0.058417674,-0.0063653495,-4.809625e-08,0.011019141,0.020965952,0.09524474,-0.06803785,-0.035748485,0.044597894,0.08661327,-0.017837696,0.0017562466,-0.009961768,-0.06929594,0.09215437,0.030954761,0.030105041,0.037737265,0.011851283,-0.053524785,0.001564543,-0.005557176,-0.0017349209,-0.05052238,-0.06725864,-0.057686795,0.11180971,-0.024367,-0.079412565,0.041767478,0.031049471,0.015539872,-0.011224634,-0.050615586,0.031057943,0.003062229,-0.01223005,-0.06421557,0.008941446,-0.035384793,0.006243399,-0.091175556,0.03735715,0.03254946,-0.023149474,-0.043625936,0.021366205,-0.0028288958,-0.016941162,0.022483781,0.015331704,-0.019221872,-0.015113616,0.11244596,-0.01854184,-0.06898805,0.010449412,-0.053410735,0.02246746,-0.05970811,0.0051895296,-0.011427816,-0.058623545,-0.0015176624,0.0053971894,0.18087062,-0.15128133 +1.17.99.8,"Contains FAD. The enzyme, characterized from the bacterium Castellaniella defragrans 65Phen, hydroxylates the R- and S-enantiomers at a similar rate. The in vivo electron acceptor may be a heterodimeric electron transfer flavoprotein (ETF).",384,1.0,-0.05208436,-0.05560754,-0.1114351,-0.06849269,0.12653899,0.02938471,-0.056219306,0.07340583,-0.007277732,0.0063462397,0.015809763,-0.04962277,-0.04428591,0.045464363,-0.050434075,-0.030690785,-0.06649349,0.044791333,-0.035103858,-0.026467526,-0.018928494,0.02327601,0.022631876,-0.023167456,0.04152249,0.051083513,0.026413413,-0.049149018,-0.0628097,-0.06038795,0.089177154,0.0943066,0.008514177,-0.027271912,-0.047024146,0.06270374,-0.021659765,-0.051124774,0.076363035,0.024449661,0.01273457,-0.047278326,0.05364584,-0.024463182,-9.661013e-05,-0.019796029,-0.0044276216,0.053217277,0.015881851,0.01719263,0.01664818,-0.022880169,-0.051856987,0.09400836,0.0004959064,0.05651059,0.006021716,-0.097422265,-0.05722975,0.006685158,0.04346979,-0.022256557,0.027255395,0.06788582,-0.027232977,-0.03425843,-0.015715957,-0.055815734,0.002726595,-0.04415801,-0.005912898,-0.06654303,-0.047347438,0.033040643,-0.0012269999,0.03522877,-0.00553523,-0.042895783,0.06758334,-0.02374232,0.042772472,-0.031621177,0.07804269,0.09119575,0.07608484,0.00839817,0.020881731,-0.0057000117,-0.06830782,0.030173153,0.052373756,-0.0063958457,0.00039066453,-0.0516514,-0.07025116,0.05412237,0.017830925,0.0027089883,-0.044037122,-0.0152164735,-0.026038742,0.03831557,0.04130963,-0.03246196,-0.13158278,-0.09802341,-0.00023024017,0.11234891,-0.05677829,-0.033351444,-0.0033545028,-0.013743648,0.04927881,-0.0044437475,-0.030655531,0.030825067,-0.007172461,-0.07907139,0.01149931,-0.064271875,-0.021114511,0.031714708,0.00955912,0.08180465,0.074312955,0.01414355,-0.1223145,2.9463444e-33,0.06619225,-0.002185297,-0.005159782,-0.038612045,-0.019193428,-0.0037376084,-0.047786996,0.023447368,0.0023606732,-0.06592033,-0.10782931,0.056709435,0.04566412,0.005577841,-0.005676396,0.009710987,-0.06542095,0.029926479,0.0818108,-0.077396184,0.09937045,0.057085898,-0.018419338,0.011328706,0.01641213,-0.026273703,-0.021375732,0.032488413,0.045898385,0.021937223,0.027628204,-0.03357175,-0.07985111,0.04799354,0.0111743715,0.011138186,-0.038400978,-0.06989936,-0.045528036,0.039192993,0.026098583,0.06525842,-0.0030318343,0.013259079,0.0099812215,-0.04765239,-0.058311768,0.03706106,0.052303918,0.103878506,0.079622224,-0.03961638,0.118102156,0.0014304507,-0.035377,0.042866897,-0.064084545,0.022340192,-0.0016414421,0.028002642,-0.027049761,0.090294786,0.0066005425,0.03291327,0.01850422,0.019043313,-0.005746293,-0.10231366,-0.018972516,0.06885793,-0.009965287,-0.022078622,0.11048695,0.024298511,0.10274684,-0.043870788,-0.06947637,-0.02442308,-0.020049443,-0.0068525816,-0.03955459,-0.0671786,-0.011760333,-0.0031116032,-0.029152293,-0.04246748,-0.0556276,-0.041498818,0.05914155,-0.01580568,0.08925928,-0.10342987,-0.073277585,0.036819734,0.03295481,-2.040234e-33,0.035853587,-0.11199427,0.013689546,0.054350585,0.020595249,0.10474862,0.07227112,-0.004771043,0.11768191,-0.016552122,0.0996733,0.033552032,-0.017959643,-0.07442591,0.0402075,-0.053495213,0.00051631726,0.019037213,0.023290688,0.00040033826,-0.016504552,-0.019317128,0.07655592,0.048498135,0.099476725,0.040063318,-0.032033496,-0.015782045,-0.010118322,-0.015928261,0.0033552202,0.03349682,-0.08372746,0.011604823,-0.083789,0.016513957,-0.008668029,0.074233115,-0.029441733,0.003558405,-0.03944859,0.025862142,0.014581683,0.10490833,0.09160888,-0.0102846855,-0.06952397,0.034077793,0.051569417,-0.050846227,-0.035332985,0.03321829,0.008992584,-0.002777785,0.09074735,0.06278199,0.07282104,0.008565303,-0.0071178433,-0.027475044,0.00634041,-0.069076665,-0.0062789717,-0.026928991,0.056135245,0.022338483,0.002872523,0.08150669,0.009391083,-0.026470799,0.15175487,-0.00724743,0.022106756,0.09017641,0.018095285,-0.040884797,0.023073528,-0.056932792,0.014767129,-0.008079964,0.0436938,0.00036302465,-0.024646966,-0.009701748,-0.052491788,-0.06561623,-0.006049241,0.018955287,-0.014913262,-0.016764058,-0.013077558,0.028588718,0.012087696,0.0084268525,0.15401714,-3.9003428e-08,0.030418728,-0.045864783,-0.03153578,-0.058584023,0.05657303,0.042939536,0.019802935,-0.021517932,0.037932217,-0.07451909,-0.004161062,0.109280065,0.018352555,-0.008179976,0.10532597,-0.041098252,0.026168162,0.016991572,-0.08089497,0.02958679,-0.022414327,0.003855702,-0.1170159,-0.021140665,-0.017886477,-0.008066072,0.023749739,-0.034558233,0.021845715,-0.025051707,-0.061022013,-0.024228508,0.0302878,0.01701716,-0.08217736,0.058867816,0.012546493,-0.054163706,-0.039525762,0.064521246,-0.058745142,-0.040298484,-0.048424803,-0.046526026,-0.029371966,-0.0004132977,-0.022136878,0.01231386,-0.028662223,-0.05099515,0.04026285,-0.052603133,-0.015103998,-0.058799114,-0.12139837,0.036866818,-0.08631265,-0.066052444,0.019993149,-0.062302187,0.010633415,0.012326748,0.14215674,0.01801477 +2.7.2.17,The enzyme participates in an L-lysine biosynthetic pathway in certain species of bacteria and archaea.,384,0.99999994,-0.039067436,-0.09351692,-0.091004275,-0.008834947,0.12685876,0.057395533,-0.12953097,0.008567654,0.048699748,-0.00012633139,-0.01782851,-0.041045357,-0.017442057,0.012462123,-0.03315116,0.07826497,-0.14438152,-0.024662515,0.01788813,-0.012021388,0.10155797,0.1021603,-0.037821367,0.016035063,0.0056615653,-0.05538102,0.058138486,-0.05053797,-0.04862634,-0.008860701,-0.0048649427,-0.0859659,0.063263364,-0.07649314,0.038915038,0.1008217,-0.058476415,-0.060381476,0.124053165,0.01789757,0.018569492,-0.03135341,-0.019666746,-0.04152087,-0.042169362,0.028262284,0.024847554,-0.010987662,0.014143063,0.033623718,-0.03314948,-0.028167514,-0.07055934,0.015639521,-0.044877462,0.02738802,-0.055821944,-0.011649516,0.027921097,-0.021854628,0.057193622,0.051513184,0.04664911,0.042732593,0.012183621,-0.10459216,0.01595315,-0.034560937,0.055408556,-0.11167672,-0.027372338,-0.103486404,0.0068011633,0.052643914,0.037347693,0.015908627,0.0192169,0.023902811,0.01271154,-0.036165386,0.03185336,-0.056111492,-0.0126573425,0.08400605,0.032735605,-0.07101844,0.014470876,0.04645501,0.0575896,-0.007962886,0.06953175,-0.0949074,-0.019422036,-0.023947082,-0.046784803,-0.049064085,0.04433482,-0.020936605,-0.020013258,-0.043282982,-0.0516578,0.032383703,-0.029413424,-0.023013242,-0.040608875,-0.036896978,0.023878181,0.09128787,0.009870083,-0.05561601,0.061338045,0.0130577935,0.08960436,0.06239503,0.0012177797,0.07694415,0.03261766,-0.06406714,-0.065955326,0.03316111,0.016819557,-0.022271683,0.058070704,0.046447873,-0.064063735,0.077210024,-0.11739546,-1.5272718e-33,0.087154806,0.03027362,-0.008867883,-0.071675204,0.034990724,-0.032072667,-0.0866669,-0.023367152,0.006252784,0.027979419,-0.044288535,-0.06876847,0.085772775,0.012488115,-0.06079648,0.04892606,-0.03147962,-0.029410316,0.008923264,0.042645313,-0.036914226,0.0287716,-0.004254733,0.057501733,0.025587998,0.036653727,0.078950934,0.0043112137,0.019309722,0.009652945,-0.04169875,-0.15085976,-0.06133484,-0.0056540393,0.1009123,0.02276406,-0.01298505,-0.06118126,-0.0025449293,-0.032561127,-0.0024126698,0.054171078,-0.022003926,-0.035773292,0.039591525,0.0317135,-0.042506482,0.10089962,-0.019558337,0.062260758,0.05987516,-0.05563837,0.07562706,-0.025733063,-0.09627097,0.0052532116,-0.056198582,-0.005455292,0.02400583,0.025956763,0.04970264,0.06386421,0.03102051,0.068191655,0.047966205,0.012625283,-0.015280543,-0.018703096,0.009978686,0.030138923,-0.08217576,-0.051593203,0.07876205,0.012645935,-0.004616812,-0.041491844,-0.0682559,-0.05112132,0.01170954,-0.02477064,0.022113483,-0.064333014,-0.008239744,0.036722418,0.01617219,-0.018356007,-0.027649917,-0.04632431,-0.0030826924,-0.029267212,0.025174323,-0.0575451,0.010786052,0.06252347,-0.06020216,-1.32051895e-33,0.06856197,-0.14803629,0.05407538,-0.062870055,-0.020365143,0.029619707,0.0042969664,-0.02411438,0.04330966,-0.00928791,0.07057391,0.011061905,-0.008491904,-0.037983403,0.04075127,0.0019473116,0.033087876,-0.00069805724,0.009174533,0.043479722,0.059333753,0.005251278,0.01625647,-0.02317905,0.055515762,0.01316425,-0.04051357,0.10532334,0.00037016204,-0.0034375547,0.011801589,0.013265934,-0.030891325,-0.10547108,-0.044214908,0.06231944,0.0035277873,-0.047181983,0.05157348,-0.009752636,0.05466487,-0.008687577,0.005718911,0.059241805,0.022159902,0.02175666,-0.06737956,-0.018560784,0.0013324164,-0.08014519,-0.01737324,-0.04054698,0.058971,-0.001789072,-0.012768574,0.043975852,-0.039036278,0.09509738,-0.034060705,0.00461885,-0.02156317,-0.058008898,0.00040866743,0.044405043,0.0015499147,0.012927575,-0.030435741,0.053753857,0.00982707,-0.04142269,0.09092107,0.015806,0.070577584,0.11034606,-0.04085415,-0.024915358,-0.07506043,-0.13636996,0.028350094,-0.014536468,-0.039248645,-0.0011604723,0.028223976,-0.05923123,-0.021100357,-0.0947874,0.014800157,0.12312597,0.01927075,-0.004902489,-0.0041745384,-0.052805837,-0.028460484,-0.05206968,0.07116384,-2.4690285e-08,0.04328331,-0.035043634,0.053754367,-0.022455765,-0.040672082,0.010366018,0.0038384104,0.04112878,-0.0021310323,-0.038680624,0.035247117,0.04850903,-0.02746393,-0.023856483,0.016382279,0.073512375,-0.049724676,0.066599526,-0.049890492,0.016957425,-0.016226433,-0.015453511,-0.051716827,0.0071038045,0.06405302,-0.062471315,-0.025617061,0.011424755,-0.021678666,-0.061949283,0.026046203,0.003753603,0.04103803,-0.051024884,-0.113596275,0.019318145,-0.057659376,-0.05816476,0.03980521,0.018411016,-0.0058994787,0.053951073,-0.10308792,0.022339694,0.022186585,0.040399533,-0.0019308048,0.042054225,-0.014576468,-0.0034250394,0.04456839,-0.05260212,0.010543934,-0.03784392,-0.036035117,-0.009322129,-0.04877727,-0.032771982,0.0107152155,-0.05922401,0.022228464,0.063862644,0.19244356,-0.09072722 +2.8.3.26,"The enzyme participates in the methylaspartate cycle, an anaplerotic pathway that operates in some members of the haloarchaea and forms malate from acetyl-CoA.",384,1.0,-0.00096482964,-0.05044993,-0.07642367,-0.018229816,0.03679486,0.100556724,-0.075095944,-0.0071069873,0.051485546,0.009119177,0.035184704,-0.06740967,-0.010667709,-0.048839062,-0.054557346,0.06529036,-0.099912375,-0.097279795,2.6286968e-06,-0.034549247,0.11540399,0.030267263,-0.07084003,0.020245863,0.025605505,0.014024365,0.032948695,-0.065252945,-0.009552183,-0.09273422,0.0003141773,0.020603204,0.029889524,0.048853632,0.024095427,0.08202309,0.028950213,-0.06625683,0.023940135,0.0056301523,0.058554336,-0.012512309,-0.059566412,-0.05046,-0.032220755,-0.027770411,-0.00032539412,-0.021915125,0.047470443,0.0069459463,-0.05077945,-0.12105868,-0.019954959,0.040564142,0.02764817,0.0792104,0.011957658,-0.030319486,-0.005678651,0.0025168539,0.010799604,0.0077439426,-0.046971872,-0.00606435,0.042461157,-0.11061973,0.08544875,-0.07121709,-0.03414173,-0.06601716,-0.062814504,-0.082383886,-0.061560147,0.07222857,0.0016754132,0.012541276,0.03530471,-0.061714876,0.07020069,-0.023499709,-0.032534584,0.06137149,0.045192383,0.036659636,0.029968748,0.006798582,0.009060983,-0.011473994,0.07098678,0.03554722,-0.05402314,-0.05398014,0.0039577787,-0.053476807,-0.046406694,0.069976375,0.05379668,-0.04908536,0.0881307,0.015259841,0.03943597,0.052083347,-0.037241336,-0.06713441,-0.10311225,0.022370046,0.031082125,0.027031258,-0.0025927075,0.018290391,-0.007725666,-0.0064371843,0.089378364,0.0032158047,-0.0055305576,0.07122973,0.015946418,-0.042427693,-0.05543734,0.048068043,-0.01635501,-0.020326259,0.10146241,0.09765281,0.026913164,0.019422913,-0.112768464,-1.0821289e-33,0.11110095,-0.012554805,0.044794463,-0.01945736,0.013189625,-0.03283717,-0.032626968,0.003931642,0.0075711934,-0.1146578,-0.02966848,-0.041594487,-0.010429518,-0.02795561,-0.022077514,-0.00899543,0.00041833104,-0.011462937,0.0006392131,-0.009731658,-0.10791075,-0.017226852,-0.019802567,-0.034163576,0.027265687,0.017580617,-0.019655114,0.03409149,0.061506253,0.028600173,0.015031013,-0.018159073,-0.08231713,0.042968433,0.05382582,0.06331497,0.029695332,0.010247592,-0.053866003,0.099034786,0.0692577,0.01975989,-0.015109001,-0.01831272,-0.045361023,-0.06007315,-0.05890136,0.03622915,0.043717064,0.038411204,0.033335276,-0.010325337,0.13647287,-0.03605383,-0.030731784,0.09340569,-0.07402781,-0.11334076,-0.004033211,0.04594327,0.002723887,-0.003954422,0.0025070268,0.062297754,0.018601697,-0.015746469,-0.06681813,-0.023826184,-0.0051289527,0.07054871,-0.078784995,-0.06250611,0.05541816,0.068836816,0.019533332,-0.062158678,-0.055216882,-0.0066382256,-0.040638506,-0.01644957,0.01340916,-0.019796586,0.03859855,-0.06552508,-0.04145874,0.010644435,0.07052798,-0.06410194,-0.04328594,-0.042782575,0.03464465,-0.032540515,0.051231347,0.036332242,0.041561313,-1.4655503e-33,0.074900135,-0.1131109,0.014862327,-0.06653169,-0.0034988653,0.06959506,0.02334417,-0.025053628,-0.04741739,0.032771662,0.065045305,0.03408843,0.02038053,-0.040396903,0.008568877,-0.018389095,0.080617875,0.045806766,-0.003037346,-0.0011218872,-0.022734975,0.055369478,0.03587394,0.0063922447,0.012394831,-0.016312664,-0.08816274,0.05922265,0.024503114,0.06721687,-0.0381221,-0.004935345,0.00866225,-0.101675585,-0.07148833,0.07131478,-0.09530594,-0.028911838,-0.032410704,0.04382677,-0.016355615,-0.0139847305,0.02874285,0.0488521,0.04033766,0.038301002,0.006776433,0.010377404,0.008692217,-0.046906624,0.06723782,-0.038073886,0.05626764,0.1039254,0.036275245,0.0825935,0.012144454,0.06495987,0.0044787303,-0.059160616,-0.09019841,0.03027211,-0.01908097,-0.05434181,0.05515347,0.0009245045,-0.019691862,-0.025026394,0.04126938,-0.017190102,0.014653693,0.037747826,0.04776964,0.07449162,-0.0021227652,-0.061869744,-0.09667216,-0.044767726,-0.064222276,-0.062649645,-0.06078243,0.031706247,-0.017913802,-0.097154744,-0.092901126,-0.097669095,0.010366263,0.05810126,-0.05685865,0.043291427,-0.06869765,-0.00060442375,-0.061542034,0.074576996,0.032780785,-2.9721397e-08,0.011856516,-0.059694093,-0.010158375,-0.05663401,-0.008941318,0.01994374,0.026474478,-0.014334868,0.07184558,-0.028885014,-0.016783983,0.0739493,0.086432986,0.0416846,0.0067183813,0.04235364,0.032133244,0.066790104,-0.03462198,-0.023138389,-0.06714755,0.011334551,-0.033686172,0.052315313,0.01967782,-0.003975801,0.023527429,0.13719985,-0.05060215,0.0078027486,-0.006782056,0.11141258,0.018254176,-0.07207761,-0.10788244,0.05215015,0.0317868,-0.017640758,0.027380344,0.04577121,0.053311616,0.043153077,-0.07098722,-0.0247335,0.028419662,0.03153334,0.014503456,0.013761616,-0.0030931488,-0.05034313,-0.020386685,-0.0027158342,-0.020162024,-0.008588018,-0.077276886,-0.024921887,0.013763766,-0.094422445,0.030521378,-0.03766009,0.014975711,0.028637292,0.16370584,-0.040989857 +2.9.1.3,This bacterial enzyme converts 5-methylaminomethyl-2-uridine and 5-carboxymethylaminomethyl-2-uridine to the respective selenouridine forms in a two-step process that involves geranylation and subsequent phosphoselenation of the resulting geranylated intermediates. The resultant seleno-phosphorylated uridine intermediates further react with a water molecule to release a phosphate anion and 2-selenouridine tRNA. The enzyme contains a rhodanese domain.,384,1.0,-0.0055378,-0.04406128,-0.059260212,-0.013830574,-0.02687941,-0.035335705,-0.011597503,0.020005826,0.033042487,-0.048733827,0.029046392,-0.04057637,0.020108752,0.05176671,-0.0401169,0.03144511,-0.090052985,0.05792055,-0.017666405,-0.058099404,0.11929829,0.026985984,-0.062225122,-0.035955,0.035113964,-0.021609427,0.084153384,-0.010155402,-0.036702976,-0.07683312,-0.00017790086,-0.043119356,0.015241274,-0.06708298,0.11984044,0.055901594,-0.06759067,0.0033770127,0.074338354,0.015936144,-0.015923204,-0.06187468,0.034082014,-0.028754285,-0.06353802,-0.004782423,0.026629984,0.043942414,-0.0059964554,0.00300103,-0.09859832,0.02495033,-0.04769804,0.02822963,-0.0023156076,0.030904302,-0.039024517,-0.041848548,-0.058744874,-0.019590957,0.041438024,0.016984407,0.0051960954,-0.04196773,-0.03761757,-0.07365807,-0.0039004048,-0.056137465,0.00061633694,-0.021395998,-0.11490075,-0.04269251,0.06595869,0.008935292,0.025947548,-0.04950729,-0.028911673,-0.00442696,0.066123374,0.021023078,0.034296356,-0.040680006,0.039767057,0.050808344,0.0036118506,0.03075073,0.006664001,0.023659412,0.04236889,0.041455876,0.03953975,-0.0036656023,0.04306489,-0.09988005,-0.031033285,0.036360584,-0.037287727,-0.026336094,0.031785093,-0.03844707,-0.035984613,0.027514398,-0.0013806546,-0.10496627,0.012702292,-0.0427031,0.022299318,0.12896988,0.072633326,-0.049494438,0.013840171,0.00096226146,0.044427823,0.010229417,-0.032504268,0.1489347,0.0038616252,0.0130881155,-0.05242199,0.00822269,0.0072079357,-0.034596153,-0.037404474,-0.031984515,-0.04588976,0.022996914,-0.104392156,5.961454e-33,0.06446058,0.078058645,-0.012055688,0.0056018336,-0.025309809,0.016303759,-0.06263005,0.015105872,-0.048584316,-0.100037105,-0.109786786,-0.09761677,0.018442705,-0.010151844,-0.047461838,-0.010354477,-0.06199024,0.07772032,0.069563836,-0.029935567,0.08362209,0.10184282,-0.026795924,-0.0044283345,0.029689105,0.010090286,0.0010428525,-0.010810086,0.031903442,0.002372844,0.055096664,-0.014128747,-0.0994122,-0.022484774,0.15292664,-0.029551214,-0.019467352,0.029210364,-0.06461872,0.026162013,-0.036954623,0.04988384,-0.0047726557,-0.0019542119,0.017284341,-0.08317564,-0.017736092,0.10729855,0.04697922,0.11430875,-0.008110618,-0.00067487697,0.11206422,0.02144416,-0.06498618,-0.028643023,-0.033217102,-0.049430978,0.060897637,0.0046823574,0.013014828,0.029741745,-0.060811736,-0.063649006,0.080402784,0.0025603627,0.016876452,-0.11010195,0.050222266,0.06894977,-0.056162626,-0.0041271136,0.004023804,0.05106114,0.018929955,-0.031950764,-0.07226155,-0.03969301,0.06168713,-0.020145334,-0.002706567,0.0135991,0.061549727,-0.030905295,0.006530193,-0.071943425,-0.05113419,-0.016491683,-0.031119935,0.001974391,0.07274266,-0.12651716,-0.08310821,-0.0006146344,0.0424993,-5.4126927e-33,0.124564126,-0.11370713,0.04129945,0.028289696,-0.009184503,-0.011280868,0.05810137,-0.014271006,-0.013389769,0.032239027,0.08511823,0.054998353,0.03400204,0.024206327,0.011017008,-0.07255751,0.10417686,0.057805736,0.026060186,-0.014685425,0.029274192,0.057065964,-0.01183169,0.051781643,0.01558982,0.052197695,0.053457603,0.00093341107,-0.0012928091,0.07441956,0.012187224,-0.037288994,-0.008155438,-0.028511658,-0.049510676,0.10583097,-0.0264865,0.03644134,-0.019167796,0.007765839,0.025757806,-0.045077488,0.0065279463,0.048633482,0.03068603,0.0033655479,-0.0812754,0.08002171,-0.030345395,-0.1133558,0.01056651,0.004927883,0.022265764,-0.066901155,0.026097553,0.009333438,0.029602693,-0.0033886197,-0.098543875,-0.019123232,-0.07956292,-0.030917834,0.028678102,-0.018505413,0.033906937,0.06293994,0.01954105,0.055273753,0.0362924,-0.11740258,-0.004304576,-0.028347725,0.04507771,-0.013552384,-0.020177053,-0.1264077,-0.07406071,-0.028032372,0.03649871,0.009050039,0.02332591,-0.045558546,0.017789483,-0.033523686,0.009595286,-0.053040523,0.054729626,0.06294862,0.010013782,0.050901823,-0.010937534,0.05258624,-0.017889412,0.056219764,0.09881634,-4.3415497e-08,0.013949372,-0.05100859,0.05667008,-0.030000834,0.035134163,0.07923446,-0.00876431,0.05987238,0.04334186,0.0016633299,-0.04903175,0.04657727,0.018375222,0.029351866,0.038009044,0.05104664,-0.013539572,0.03580073,-0.016572267,-0.034657195,-0.060200937,-0.029816415,-0.14065114,0.03195326,0.09752395,-0.054371506,0.01710525,-0.02420659,0.0007530401,-0.03703882,0.06034996,-0.022682928,0.014501196,0.013178889,-0.110255994,-0.031718623,-0.039123345,-0.035850264,-0.002335433,0.004919572,0.037502877,0.07643006,-0.07941627,0.015741542,0.014203976,0.031065222,-0.021728612,0.0031252038,-0.06290613,-0.016352179,0.062875666,-0.04751121,-0.018371513,-0.00016847688,-0.046293736,-0.0024108242,0.006189633,-0.09514701,0.027422927,0.046614323,0.026092393,0.054359682,0.14956233,0.01101189 +3.1.3.108,"The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC 2.7.1.23) and NADP+ phosphatase with a slight preference for NADP+ over NADPH.",384,1.0,-0.085823596,0.06815742,-0.045408778,0.032740045,0.041499183,0.04491579,-0.08218001,1.8760446e-05,0.075143784,-0.016955154,-0.08112533,-0.01718002,-0.04719255,0.050710525,0.015455274,-0.0012934858,-0.049599696,0.027832324,0.07112144,-0.0036701465,0.04035683,0.02733739,0.03385109,0.0061156335,0.05951024,-0.015010118,0.05999895,0.0023254307,-0.020822616,-0.016320067,-0.04899084,-0.016968945,-0.04715811,-0.027686466,-0.026380029,0.12619285,-0.014847129,-0.04881043,-0.01682333,-0.023086572,0.08525323,-0.0062793447,0.0014745005,0.019017998,-0.06788943,0.010703185,0.020550964,0.029885795,0.003064848,0.0050815735,-0.052501578,-0.033377565,-0.05966997,0.010462063,0.053520348,0.11105663,-0.010988934,-0.038157642,0.025583157,-0.10096168,-0.018192431,-0.03479264,-0.008795346,0.015192819,0.06254739,-0.04377416,0.013821902,-0.015337606,0.032584507,-0.0762923,-0.08697616,0.00440856,0.03517097,0.044698235,-0.04501308,0.015019818,-0.04739433,-0.048566543,0.067798406,-0.010218692,0.010431634,0.009697243,-0.031683728,0.053070713,0.091475956,0.011310988,0.024051063,0.062292483,-0.026005084,-0.015763449,0.020882377,-0.026563302,-0.027266558,-0.027267447,-0.15685017,-0.01741662,0.06075322,0.0802518,-0.05048995,-0.022985293,0.024968889,0.0820833,0.0014892287,-0.022785388,-0.03395594,0.010832104,-0.06700161,0.079309516,-0.039027043,0.006251939,0.027918447,0.011101407,0.035444282,0.009572289,0.055614013,0.11888544,-0.04019958,-0.026152642,-0.057194483,0.014884851,-0.04560334,-0.004873551,0.04351978,-0.054295562,0.015620611,0.05238904,-0.07241009,2.2829994e-33,0.058002084,-0.03070374,-0.03751215,-0.050793495,0.05559914,-0.010331915,-0.10140083,0.029584918,0.020738818,-0.058835115,-0.0015421099,-0.04146986,0.0016105671,-0.010425105,0.0028943422,0.0123804575,-0.0056194835,-0.0042745895,0.0607928,-0.031528853,-0.019647446,0.039483804,0.036439154,-0.035097744,0.020292157,-0.016811114,-0.057948858,0.030878697,-0.0024009934,0.02014947,0.0771978,-0.12063369,-0.12200361,0.013540844,0.094723806,-0.011885938,-0.03566298,-0.07031193,-0.06171648,0.02742642,-0.09206606,-0.009521491,-0.016674673,-0.062196143,0.033406124,-0.061224904,0.0021017191,0.07194705,0.004187198,0.024505462,0.037623342,-0.03992341,0.09418341,-0.116894916,-0.06405751,0.047808383,-0.018414566,-0.06583006,-0.022078574,0.07600997,0.062882684,-0.012665274,-0.033360917,0.059230905,0.0145860035,0.02551247,-0.059959274,-0.09886171,0.055259906,0.10782858,0.043045476,-0.0006456621,0.063253485,0.023495268,-0.050248023,-0.005535731,0.07575616,0.0066620684,-0.046767607,-0.0038875926,0.066573486,-0.040953133,-0.014968707,0.007832305,-0.0028967506,0.026858997,0.054206893,-0.0010892384,-0.01157292,0.023399543,0.037172597,-0.07316836,0.014128437,0.016020862,-0.019873912,-3.260481e-33,0.08927203,-0.1191128,0.06007931,-0.109537035,-0.020087544,0.10048704,-0.0014709493,-0.057760313,-0.0052469163,-0.05259425,0.09882831,0.0122568775,-0.00023577131,-0.028627455,0.07542754,-0.08883588,0.028759943,0.015564778,0.018722484,-0.022978662,-0.0010466818,0.10279294,-0.04464933,-0.02110655,0.08256628,-0.049609136,-0.041279633,0.08971138,-0.017703116,0.018761793,-0.033420213,0.055867806,-0.030548938,-0.055041783,0.019776195,0.011055581,-0.06500862,-0.03668936,0.0311708,0.044734392,0.05093035,0.07063757,-0.06637909,-0.007880796,0.013957501,0.041531898,-0.120350026,0.023075541,0.016583817,-0.043484643,0.0633813,-0.0029053912,-9.25049e-05,-0.02773406,0.022720957,0.034274634,-0.011694212,0.037404697,0.12766916,0.015437693,-0.081669845,-0.065879524,0.05299244,-0.018961405,0.03522525,0.017464943,-0.031183885,-0.050486993,0.017281557,0.022515044,0.07563484,0.001182827,0.0035402665,0.07860324,-0.024266874,-0.0658976,-0.053008907,0.067515045,-0.01958089,-0.040279575,-0.049945485,-0.05202129,-0.003453087,-0.047814354,-0.07114612,-0.03335613,0.01839188,0.04253574,0.024104,-0.0040113954,0.015337012,-0.0038093722,-0.1306259,0.04749064,0.0047451286,-3.7470492e-08,0.037055783,-0.00353792,0.061857726,-0.00797321,-0.022711808,0.02384745,0.12222879,-0.041175712,0.035732977,0.05153642,0.11448494,0.08633979,0.05780579,-0.02871281,-0.0025142964,0.031318374,-0.04940818,0.024612492,-0.019156488,-0.02090558,0.043642573,-0.03491586,-0.038070653,0.058134954,0.05663666,-0.021071425,-0.004937583,0.06904599,0.053402107,-0.058061883,-0.0033940244,-0.008243144,0.08802098,-0.05022743,-0.07633423,0.0017058637,-0.0392822,-0.023604525,-0.07322776,0.06628397,0.012013716,-0.07735903,-0.07217134,-0.009232347,-0.023026016,0.0085218735,0.095010854,-0.020670148,-0.081886694,0.018453803,0.003418629,0.0005784787,0.04487244,-0.062965795,-0.08613746,-0.0045863306,-0.016070317,-0.095614314,-0.104197085,-0.051933717,0.09947003,0.07751133,0.077894144,-0.05920217 +3.2.1.211,"The enzyme specifically hydrolyses (1->3)-alpha-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1->3)-linked or alternating (1->3)- and (1->4)-linked alpha-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the alpha-L-fucopyranosyl residues may occur at positions 2 and 4. The enzyme degrades fucan to sulfated alpha-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced.",384,1.0,0.03124339,-0.07956692,-0.088204354,-0.027257444,0.02110842,-0.039369788,-0.044865802,-0.005519272,0.10921949,-0.0032006644,0.07601531,-0.0022727402,-0.025592994,0.011321024,-0.08728734,0.015701916,-0.047231227,0.028989574,-0.010314243,0.057540305,0.059544723,-0.025663616,-0.07061238,0.03883226,-0.023679364,-0.06908558,-0.05386737,-0.033664685,-0.07840338,-0.09139158,-0.01578089,-0.014863258,0.036928806,-0.009996562,0.054406177,0.032944772,-0.03647847,-0.045893088,0.013972704,-0.004686393,-0.026174853,-0.016496882,0.01942281,-0.062225793,-0.07465142,-0.08185931,-0.047875218,0.011351496,0.034719497,0.03784177,0.012241741,-0.109481715,-0.085503556,0.04160257,0.041025877,-0.008798654,-0.028910434,0.019416394,-0.015473237,0.1004287,0.007279566,0.11048334,-0.049244817,-0.05356335,-0.055042036,-0.041696176,0.00091236434,-0.029861,-0.044729408,0.041268375,-0.06907758,-0.0072053117,0.057334915,-0.0043594413,0.023870522,0.08184296,0.024919597,-0.025468212,-0.008428074,0.00090234797,0.011867317,0.055810727,0.013177105,0.04299074,0.0477674,-0.046982616,-0.03957569,0.0057709906,0.052195586,0.07746777,0.06242155,0.0036717877,0.0011610434,-0.05538236,0.044848964,0.013820256,0.02551521,0.07902194,0.057861816,-0.058051642,-0.020261474,-0.06488597,0.046626545,-0.15694278,-0.027608914,0.068453506,-0.019104918,0.06061339,0.07701227,-0.043490157,-0.08440762,0.036345776,0.039890617,-0.03183394,-0.06635833,0.059645787,0.03687137,-0.071030095,-0.023025988,-0.022559341,-0.01908013,-0.008362484,0.16045873,0.066650525,-0.0030925926,-0.0004078599,-0.071509115,1.5349781e-33,0.057478927,0.026008174,0.06369193,0.022006964,-0.0067711254,-0.12059401,0.017391697,-0.053843573,-0.08272884,0.026650524,-0.1006021,0.005421749,-0.0536913,0.054016862,-0.025996974,0.019682791,0.03505902,-0.09211813,-0.045736697,-0.01366828,0.0048699444,0.011783914,0.022236485,-0.07014136,0.036415692,-0.0006538207,-0.06738925,0.020989336,0.0406802,0.027675238,0.009707722,-0.05714569,-0.06644209,0.059529476,0.07280876,0.121029384,-0.043329965,-0.029462619,-0.06508655,0.009189068,0.06326109,0.034997046,0.003290419,-0.049512792,0.050573494,0.0012924778,0.013817477,0.073019095,0.03349772,0.06594429,0.06406835,-0.0130709205,0.019310303,0.04274285,-0.043111276,0.008570778,-0.0011921623,0.0018681211,-0.02629414,0.1006355,-0.027050842,0.02336793,-0.028787704,-0.029748563,-0.010185693,0.032486793,-0.028449295,0.026870295,0.027795779,0.00045105958,-0.06884133,-0.052970864,0.0082151955,0.021248305,0.05968392,-0.03362841,-0.04226147,-0.024073916,-0.03696053,0.020940676,0.019357871,-0.048167307,-0.009231941,-0.019885968,-0.10770319,0.041743994,0.012708969,-0.00038419283,-0.027359936,0.060532633,-0.018858325,-0.081828564,0.006138394,0.07234959,0.021633253,-4.8065648e-33,0.0114170825,-0.106519,0.061065122,-0.0467824,-0.056859605,-0.0021266523,0.0495598,0.016206479,0.003212841,-0.06664298,0.0031331722,-0.029523045,-0.00016958866,-0.046445876,0.0068780985,0.072423816,0.0024114926,0.046899844,-0.0068689366,-0.010742911,-0.05757827,0.07536486,0.112539075,0.026254544,0.023399128,-0.00657992,0.06766245,0.03221865,0.03717482,0.05071074,-0.022227436,0.06113753,0.03677165,-0.06295919,-0.07054859,-0.058351476,-0.10556242,-0.10569646,0.11748539,0.022797413,0.02884453,0.026873378,0.07708409,0.018586982,0.030959284,0.06900078,-0.057973143,0.015011091,0.039956115,0.00796343,0.018506402,-0.017595766,-0.00308132,0.091739275,0.032777525,0.027464073,-0.0018957413,0.06927775,-0.014598694,-0.0419591,-0.07350224,-0.04672328,-0.0113845095,-0.055367373,0.0552196,0.028644111,-0.0005238066,-0.028745238,0.015606086,0.04039466,0.026308216,-0.010109392,-0.08353631,-0.007843912,0.0051649986,-0.04912891,-0.14820015,0.0057808226,-0.03476867,0.018520502,-0.035405718,0.06886654,0.032082662,-0.079428814,0.08121752,-0.07061523,0.002810799,0.09458726,0.036806665,0.016493164,-0.007389559,0.0016324803,-0.027731154,0.039418116,0.05444806,-4.5302095e-08,0.03157324,-0.022877969,-0.036956724,-0.00025765458,-0.023990614,0.035292294,-0.02488948,0.04215139,-0.056434847,0.018572152,-0.023517232,0.1514482,-0.028051076,0.0021472008,-0.02281519,-0.025082149,0.0032045688,-0.0031690379,0.011956875,-0.008065863,-0.100314714,0.038490765,-0.09797977,0.052587505,-0.02961632,-0.019324757,0.0028971562,0.0026001548,-0.025000991,0.020533897,0.0341729,0.047314964,-0.09011142,-0.12803088,-0.05282654,0.069196716,-0.064916894,-0.07270577,-0.01921323,0.07240968,0.052685145,0.0019527139,-0.016059741,-0.022226598,-0.046341512,-0.0067715496,0.00062413834,0.07700472,-0.020937603,0.058276646,0.06619997,-0.03687729,-0.08196203,-0.06334057,-0.05405903,-0.023756923,0.078902856,0.0028123832,0.00970629,-0.05188267,-0.010105941,-0.03350469,0.14660928,-0.030390456 +3.2.1.212,"The enzyme specifically hydrolyses (1->4)-alpha-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1->3)-linked or alternating (1->3)- and (1->4)-linked alpha-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the alpha-L-fucopyranosyl residues may occur at positions 2 and 3. The enzyme degrades fucan to sulfated alpha-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced.",384,1.0,0.03349599,-0.07711097,-0.085348204,-0.026704729,0.020647982,-0.038156226,-0.04545899,-0.0040037166,0.10894549,-0.0031716253,0.075522125,-0.0015600766,-0.025000239,0.011710072,-0.09108079,0.016916942,-0.04778481,0.027110219,-0.010711552,0.05777354,0.057288807,-0.027659593,-0.07183498,0.036445443,-0.02615476,-0.06880881,-0.054145172,-0.035075843,-0.07839893,-0.09149805,-0.0140197575,-0.014808645,0.035712205,-0.00935487,0.052383013,0.03358706,-0.033535972,-0.045115635,0.016211981,-0.0057339156,-0.025751572,-0.016663766,0.019726643,-0.06079656,-0.074559286,-0.0823929,-0.0445551,0.011430648,0.03424288,0.03946176,0.012494702,-0.10851453,-0.08541764,0.041435122,0.04138713,-0.008037935,-0.02994639,0.017527469,-0.013544117,0.10099392,0.009467303,0.10995505,-0.05020583,-0.052497473,-0.056977462,-0.042086404,0.0022375828,-0.028069386,-0.04502983,0.040094975,-0.06701772,-0.0055229524,0.05774247,-0.0047752387,0.023793375,0.08152853,0.02324503,-0.027372254,-0.006635054,0.00206926,0.012177044,0.057422884,0.013143108,0.038910996,0.048981648,-0.045752276,-0.037080456,0.003753106,0.05455603,0.07608464,0.063792035,0.0041201413,0.0011297782,-0.057308834,0.04365103,0.012118522,0.025847841,0.079805724,0.058577724,-0.058912557,-0.020938648,-0.06720647,0.044400685,-0.15669209,-0.027164182,0.06588872,-0.016012805,0.061289396,0.078405395,-0.044791423,-0.08411803,0.037197735,0.04030695,-0.030489134,-0.06526168,0.05849378,0.035339355,-0.06958274,-0.024998235,-0.023373244,-0.02019872,-0.00779061,0.1607751,0.06754572,-0.0020477714,-0.001062336,-0.072980456,1.53047335e-33,0.05962633,0.026743814,0.06594426,0.021694275,-0.005311534,-0.12129462,0.016950743,-0.052673504,-0.08404953,0.026528303,-0.1002205,0.004324893,-0.054265976,0.054671302,-0.027365323,0.019052684,0.0361544,-0.092950754,-0.044261605,-0.013883083,0.001656285,0.013456798,0.023280863,-0.069334716,0.03596242,8.167136e-05,-0.06785869,0.02051951,0.04041571,0.028461942,0.0060848384,-0.056500867,-0.06737803,0.059106197,0.07436982,0.12039898,-0.042952046,-0.027164165,-0.063746266,0.0056937616,0.062475286,0.035440415,0.0024091331,-0.050057456,0.051118802,-0.00034443897,0.0112572545,0.07378794,0.033192422,0.06602227,0.06221009,-0.013773111,0.019710982,0.042521786,-0.044908885,0.008744987,-0.002068822,-7.277151e-05,-0.027457986,0.10186154,-0.024636514,0.024796333,-0.030495308,-0.030203396,-0.008700326,0.03022031,-0.025728263,0.02419188,0.027369754,0.0013522486,-0.06769834,-0.053472206,0.010000854,0.020069461,0.0597291,-0.034031253,-0.042233214,-0.023788918,-0.035834674,0.022642478,0.018274775,-0.047489658,-0.009171601,-0.022104084,-0.10639968,0.042010248,0.01325187,0.00060455455,-0.025831554,0.061090644,-0.019814635,-0.08253709,0.004932652,0.07053996,0.022899859,-4.8111092e-33,0.011421646,-0.10502575,0.060139865,-0.045115016,-0.05845255,-0.00223546,0.05101246,0.015654398,0.002724747,-0.065908074,0.0051569385,-0.030437447,-0.00086296536,-0.04456051,0.007518497,0.0731225,0.0015265393,0.04736005,-0.006076061,-0.010490303,-0.05889515,0.074713714,0.112927824,0.024948465,0.026712194,-0.0070750094,0.06966905,0.032653566,0.037240095,0.050329324,-0.021982053,0.060655862,0.035422903,-0.06321776,-0.07213626,-0.059698552,-0.106533766,-0.105031475,0.117839865,0.021948062,0.029396683,0.026243247,0.07661206,0.019613558,0.030769216,0.06622707,-0.057684634,0.015777094,0.038181785,0.006328589,0.019665902,-0.016204532,-0.005007649,0.09043092,0.031681847,0.02734296,-0.0030067037,0.07021525,-0.014919828,-0.04304038,-0.07404588,-0.048224416,-0.011265366,-0.054938737,0.05475831,0.02735171,-2.7610651e-05,-0.029960282,0.013818295,0.039384,0.026908211,-0.011178758,-0.08384371,-0.0069545535,0.0043854336,-0.047838256,-0.14751256,0.002057289,-0.035410225,0.019675115,-0.037899714,0.06932919,0.031682752,-0.081025854,0.08123566,-0.07019181,0.0035797355,0.094732426,0.03811979,0.018973554,-0.006682822,0.0015023156,-0.026772333,0.039767656,0.052660912,-4.5291333e-08,0.030641217,-0.022195257,-0.036435004,-0.0016312344,-0.024634264,0.03487256,-0.025330309,0.04119267,-0.055654924,0.017344551,-0.023426274,0.1532392,-0.029199947,0.002361216,-0.023606934,-0.024284847,0.001572096,-0.0038354928,0.011909159,-0.007132255,-0.09885077,0.03765481,-0.099350795,0.05426647,-0.030795591,-0.020650184,0.0042521744,0.0031008848,-0.024512094,0.019462267,0.035970163,0.047269657,-0.09042875,-0.13076364,-0.052396927,0.06988037,-0.06361089,-0.071712576,-0.017920472,0.072094284,0.05284629,9.268355e-05,-0.016036775,-0.022121139,-0.04639352,-0.0052375635,0.00037971121,0.0768245,-0.018802304,0.06192298,0.06485317,-0.035737738,-0.08195134,-0.064038604,-0.053405862,-0.023710843,0.08073695,0.003761079,0.010456313,-0.052938294,-0.0095991595,-0.03200026,0.14567803,-0.03134233 +3.2.1.213,"The enzyme, characterized from the bacterium Bifidobacterium longum, specifically hydrolyses (1->6)-beta-galactobiose from the non-reducing terminal of (1->6)-beta-D-galactooligosaccharides with a degree of polymerization (DP) of 3 or higher, using an exo mode of action. The enzyme cannot hydrolyse alpha-L-arabinofuranosylated (1->6)-beta-galactans (as found in arabinogalactans) and does not act on (1->3)-beta-D- or (1->4)-beta-D-galactans. cf. EC 3.2.1.164, galactan endo-1,6-beta-galactosidase.",384,0.99999994,0.012919245,-0.10415769,-0.04558033,0.014133073,0.005847728,0.036325745,-0.052331083,0.022011869,0.02580407,0.016681956,-0.0058541866,0.023798903,-0.017863816,0.021724755,-0.05615253,0.008945203,-0.01091247,0.040441643,0.006342392,0.08773003,0.13053139,-0.0428713,-0.042886697,0.04920618,0.07639713,0.014764955,0.04003191,-0.065588675,-0.059576124,-0.0887661,0.053612545,-0.0039350726,0.1129516,-0.04306119,0.0087575205,0.101511076,-0.012308281,-0.0775783,0.10815319,-0.050990216,0.060719937,0.004941165,0.09915851,-0.082664,-0.036807206,0.012213904,-0.009917525,0.03593803,0.08591162,-0.023435203,-0.022503957,-0.100278035,-0.06597452,0.02152953,0.04840878,0.0015486336,0.0001304064,-0.050358754,0.030312553,0.033992734,0.05164336,0.062596224,0.053219493,0.04343874,-0.07367577,-0.07421268,0.011571311,-0.05533958,-0.00082767854,0.009578055,-0.062277086,-0.008113497,-0.034871634,0.00088702096,0.044906415,-0.0047705583,-0.014412012,-0.035754748,0.021058673,-0.032782387,-0.014994046,-0.0542551,0.015290259,-0.021261744,-0.041897584,-0.070905805,0.056178156,0.045780104,0.03176096,0.03087593,0.039588936,0.014731733,0.010914072,-0.09912446,-0.030225547,-0.03643533,0.013815708,-0.01070548,0.037502747,-0.012745623,0.010750307,-0.024303569,0.09311483,-0.056757856,0.00041389908,0.019949643,-0.008838087,0.0884064,0.08458494,0.00078983203,-0.04992144,-0.01857949,0.047526635,-0.00911691,-0.075572185,0.04887713,-0.019309683,-0.0790293,-0.06634336,0.024558727,0.042834822,-0.044462755,0.110584445,0.009684688,-0.008949931,0.121436276,-0.043042317,1.276656e-34,0.058932774,-0.04161155,0.04030982,-0.060424816,0.030469758,0.034328446,-0.051161177,-0.030786918,-0.010016292,-0.00859146,-0.048877366,-0.0061533675,0.029785508,0.08204647,0.021382032,0.07800314,-0.0043311957,-0.02640851,0.0129136415,0.044786572,0.016273879,-0.021514565,-0.02123624,-0.035438027,0.07318273,0.0026305665,0.045459025,0.031066695,0.10185237,0.00040298793,0.0038920972,-0.054840118,-0.116164416,0.052404113,0.05020614,0.029030574,-0.033140793,-0.046702974,0.018778743,-0.028829481,0.050546873,-0.004069996,-0.013205075,0.020778354,0.052780464,-0.0067272903,0.039811134,0.041548613,0.025677864,0.09246938,0.04419052,-0.031582408,0.029203217,-0.021762319,0.0106470045,0.047321167,-0.009811021,0.08126437,-0.0039432286,0.042899784,-0.015567672,0.0709268,0.018375684,0.020464586,0.016886014,0.03268123,0.006263512,0.03769654,0.0047628656,-0.06541814,-0.052405633,-0.057185594,0.03953036,0.04503258,-0.035743203,-0.06308595,-0.017377261,-0.08038524,0.03405933,-0.010566395,-0.0063221445,0.05339297,0.017058216,-0.030255055,-0.023731058,0.07898021,-0.045371257,-0.025827488,-0.043746926,0.024929687,0.021909062,-0.032425154,-0.08098941,0.09929355,-0.0057486054,-1.6503898e-33,0.081001714,-0.100297794,0.052593842,-0.027438598,0.0008374605,0.03096862,0.052956853,0.02975092,0.021288786,-0.0634044,0.07846708,-0.0125830555,-0.016683277,-0.09953062,0.039301135,-0.03820832,0.040244784,0.06417926,-0.08339847,-0.030228036,0.0023019668,0.04182605,-0.003167482,-0.006593197,-0.03168709,-0.03655191,-0.01227226,0.06998295,0.0067630745,0.05073645,0.027682632,0.017170282,-0.07052931,-0.06148114,-0.06968588,0.014794086,-0.1107621,-0.0054621142,0.0446955,-0.00031810012,0.027692564,0.064822,0.0017070022,0.021337714,0.064115055,0.038888697,-0.054141518,-0.004821298,0.06858677,-0.017492987,-0.062540606,-0.08728365,0.014512846,0.084295124,-0.007755615,-0.02474213,0.0064960476,0.110221714,-0.050047666,-0.054500144,-0.037504602,-0.023373988,0.12148978,-0.105333745,0.037120707,0.05767059,0.00025377856,0.029508384,0.056283258,-0.043195054,0.08816875,-0.024609359,-0.07174677,0.072683506,0.06469371,0.07381448,-0.14706394,-0.0982135,-0.05290732,-0.06076613,0.07288676,0.07367983,-0.064445786,-0.02431538,0.05515165,-0.06939552,0.047546912,0.088984564,-0.031964824,0.036723077,-0.009427214,-0.037284624,-0.010031704,0.019648315,0.051103592,-3.9795744e-08,0.0023183378,-0.01006673,0.025945352,-0.09975371,0.0071654357,0.043412086,-0.019320827,-0.012405295,-0.00034042198,-0.069696166,-0.01237798,0.04312835,-0.061940495,0.060712706,-0.01155255,-0.006834746,-0.030732542,0.0063978736,-0.017348468,0.026605466,-0.10163212,-0.032238036,-0.11732616,0.0045248065,-0.039546754,-0.047924034,0.038660236,0.047156066,-0.064852476,-0.016437357,0.01583467,0.0448789,-0.064011656,-0.0018363118,-0.0837714,-0.011661901,-0.052001555,0.021828674,-0.009883493,0.015240556,0.06996089,-0.023466332,-0.038821194,-0.03152314,-0.047494557,-0.004320736,-0.046568654,0.05726213,-0.058762282,0.06551244,0.08591076,-0.039280243,-0.091667235,-0.083000444,-0.061473545,-0.00010538641,0.02666811,-0.05280001,-0.057443,0.022015017,0.009277828,-0.10047111,0.13385592,0.002953028 +3.6.1.73,"The enzyme, characterized from the bacterium Escherichia coli, preferentially hydrolyses inosine triphosphate and xanthosine triphosphate, which are formed by oxidative deamination damage. By hydrolysing these damaged nucleotides, the enzyme prevents their incorporation into RNA.",384,1.0,-0.057303753,-0.053824935,0.008662982,-0.007841784,0.01858197,0.009760111,-0.028504325,0.07512777,-0.0029013227,0.001380379,0.018868027,0.012555373,-0.04811409,0.04388979,-0.06047237,0.048800066,-0.055329714,0.009996594,-0.005195186,-0.06960935,0.11244674,0.06463985,-0.08068079,0.00865452,0.0005696861,0.071903646,0.10337447,0.00026845167,0.0098454645,-0.06724005,-0.08068993,-0.027961731,0.09252138,-0.05305056,0.05114474,0.16582693,0.013327975,-0.0993242,0.059311338,-0.010765824,0.026759606,0.018920733,-0.0039171935,-0.028704073,0.0067743557,-0.05038269,0.030444236,0.079807445,-0.021613684,0.056483243,-0.0038469573,-0.0033935062,-0.036408305,-0.03552891,0.018865041,-0.009353457,-0.02780589,-0.046481725,-0.07205941,-0.010237307,0.05326772,0.04637583,0.004034338,0.010533732,0.07534605,-0.13156627,0.10127977,-0.03144643,0.0055147214,0.03426533,-0.051546056,-0.0097903935,-0.03390231,0.0669499,-0.035900597,-0.019931247,-0.011793935,-0.059380174,0.050018284,-0.024558885,0.032552052,-0.036426574,0.04730817,0.077254996,0.018344617,0.030043337,-0.02136273,0.038532488,0.047283642,0.041079972,0.0067519466,0.0150324805,0.034346458,-0.007070726,0.0031167176,0.008483358,-0.005695865,0.020451574,0.009457156,-0.027993679,0.010808711,0.08977543,-0.03132649,-0.052069493,0.013475343,-0.0056309956,0.04025184,0.0484269,0.019009998,0.04706535,-0.02868233,-0.008626183,0.030118266,-0.018606093,-0.057705563,0.052789856,0.01940639,-0.012809283,-0.06997189,-0.014742011,0.070687406,-0.10637107,-0.0071684388,0.08206576,-0.075017095,0.017366255,-0.059690226,4.0872817e-33,0.050837394,-0.040430162,-0.025933944,-0.061519414,-0.016793882,0.009179615,-0.0009383532,0.033879507,-0.10358388,-0.015319484,-0.014202349,-0.06935791,0.053366065,0.00819802,-0.0029221314,-0.033337366,-0.038435336,0.03785928,0.032773092,0.018259186,0.022450734,0.037966497,-0.02555722,0.04477121,0.024904488,0.027448421,-0.041782845,-0.031135889,0.051827893,-0.024644382,0.0657223,-0.11273072,-0.12967074,0.04893757,0.060987923,-0.056465443,-0.028735425,-0.015039239,0.018844854,0.103135735,-0.04919118,0.007760718,-0.009359292,-0.049093403,0.05407016,-0.013876246,-0.036058072,0.030100547,-0.0052785883,-0.00910477,0.05282838,-0.036980614,0.07623562,-0.06909042,-0.03229941,0.011245316,-0.008522994,-0.017826814,-0.019337151,0.06137945,-0.025787022,0.04901298,-0.032153245,0.052726574,-0.0027933226,-0.054201957,0.017112253,-0.10667468,0.048199624,0.10660598,-0.08951995,-0.05154824,0.03425744,-0.006501183,-0.09360492,-0.07161283,-0.0799862,0.045836553,0.006612706,0.033665854,0.016695442,-0.06526867,0.015144716,-0.029265437,-0.017596588,0.03857065,-0.009013022,-0.06648046,-0.011751722,0.03445549,0.093700156,-0.04971124,-0.08197672,-0.051822186,0.024354443,-5.769368e-33,0.049430598,-0.040641103,-0.01883543,-0.024585404,-0.14670622,-0.0034259905,-0.0152955605,-0.032516442,0.006700144,-0.058773354,-0.0023050508,0.014760352,0.0055775642,-0.065808244,-0.011346124,0.015466818,0.00025568996,0.050497673,-0.06111676,-0.05011423,0.052163534,0.1059313,0.016497571,-0.0052961614,0.05857352,-0.007103321,-0.049430303,0.038910143,0.04188152,0.060482666,-0.060097363,-0.012010747,-0.010019826,-0.039488565,-0.020679003,0.06697968,-0.06997726,0.01920598,0.053158686,-0.0058446205,0.020748587,0.09599634,-0.010743251,0.089797296,0.045168694,0.06548733,-0.072300695,0.013513552,0.012696779,-0.025057305,0.031690694,-0.04093925,0.009389006,0.05760531,0.027286412,-0.013204278,-0.00064375537,0.007442011,-0.03744028,0.03231615,-0.04063849,-0.09232677,0.013605269,0.0046701413,0.011694763,0.002698974,-0.039309513,0.0760698,0.03635268,-0.063377306,0.024545286,-0.0127042895,0.007191331,0.014726215,-0.022647984,-0.008401152,-0.12093304,-0.026181929,-0.04804841,-0.03479398,0.0123999845,0.039575104,-0.0399792,-0.032796137,0.047604512,-0.07022191,0.0386364,0.13025029,0.005204198,0.048012264,0.026121305,-0.04318391,-0.050871663,0.06061739,-0.002904232,-3.6642625e-08,-0.024963127,-0.12979883,0.06241475,-0.06068863,0.029824616,0.03751916,0.04508188,0.07485064,0.12083171,-0.021070622,-0.018407512,0.03869922,-0.04752218,0.0051678047,0.07098943,0.016403826,-0.08807203,0.058047764,-0.065323666,-0.006168417,-0.040000014,-0.009861038,-0.12508965,0.092929035,-0.011016604,-0.0042103427,0.0717992,-0.027540764,0.012580202,0.0044944454,-0.0515769,0.033589903,0.06940153,-0.029040089,-0.07232127,0.03013213,-0.0023181909,-0.0046895673,-0.04412143,-0.038921244,-0.045941938,0.03344978,-0.091009505,-0.009108367,0.055406105,0.018216548,-0.0037650138,0.06430406,-0.0071919877,-0.030189978,0.059412546,-0.0048461366,0.034515724,-0.049507532,-0.105555125,0.02369721,-0.028201578,-0.04013298,4.2749223e-05,0.020378184,-0.012929669,0.015164647,0.25335687,-0.077943444 +3.7.1.26,"The enzyme, characterized from the bacterium Sphingomonas sp. SKA58, participates in an L-rhamnose degradation pathway.",384,1.0,-0.026946781,-0.042829152,-0.067337334,-0.0007142937,0.10453202,0.06478406,-0.06848873,0.0339818,-0.025388006,0.032305725,0.005449687,0.0064369338,-0.057338674,0.066315986,-0.056114744,0.08679605,-0.111464076,-0.044057254,0.0034143627,0.003031623,0.08681937,0.042181548,-0.086191006,0.04783249,0.0892735,-0.01865654,0.058832712,-0.01899226,-0.043556467,-0.015750412,0.047388162,-0.010732842,0.0854636,-0.08494129,0.029193645,0.13859938,-0.014069142,-0.03723739,0.07294181,0.029152513,-0.036692962,-0.0052688834,0.03686106,-0.05298267,-0.02107943,0.03137647,-0.070661485,0.06711542,-0.005584828,0.017750861,-0.07274833,-0.08489375,-0.030563839,0.027708257,0.0330266,0.012214749,-0.083504215,-0.017760288,-0.055842128,-0.0016808156,0.024556499,-0.0064568976,-0.00847619,0.028018296,-0.028050184,-0.077921435,0.08697371,-0.047390945,-0.020143002,0.048321992,-0.04211114,-0.051301792,-0.018281521,-0.00032440727,0.06547327,0.024846325,-0.010251217,-0.03671063,-0.022312293,-0.051833693,0.07694295,0.022883845,0.02617597,-0.01015611,-0.04494547,0.0069144303,0.054094598,0.0054449984,0.056810565,-0.014248349,0.025704265,-0.011394241,-0.018701728,-0.06529915,-0.05017461,0.051684454,-0.021955896,0.063463055,0.01471153,-0.046147164,-0.04770543,0.016872276,-0.0077369376,-0.12898292,-0.042296454,0.016115598,-0.05102121,0.11702054,0.034914326,0.02158586,0.06465118,0.048586167,0.034280546,-0.0048994566,-0.042233344,0.019816823,-0.020554371,-0.037677087,-0.13552085,0.044310085,-0.018197494,0.0008228747,-0.01744154,-0.016714154,-0.034829035,0.03240685,-0.07615229,-2.3159784e-33,0.04696247,-0.03971977,-0.010025916,-0.048031222,0.025853436,-0.09230033,-0.06414983,-0.040712547,-0.03107711,0.02173674,-0.020799369,-0.03230171,-0.014932788,-0.039694343,-0.0032646672,0.101941034,0.031262215,0.0038876233,-0.049929067,0.046656962,0.0027919067,0.031839233,-0.07689003,-0.030391702,0.08441466,0.10628207,0.06644937,-0.03823832,-0.008451346,-0.02874926,0.06788902,-0.04605238,-0.15869057,0.012107248,0.08212408,-0.04762615,-0.034197967,-0.021838186,-0.042101428,-0.02600471,0.07692865,0.024713393,-0.03766792,0.052857548,0.018977527,-0.050124362,0.019073758,0.040854577,0.04741563,0.11784157,0.056670915,-0.033254128,0.06292382,0.062359374,-0.04224892,-0.052287824,-0.040890116,-0.019630222,0.045220125,-0.012413212,-0.012733718,0.031061888,-0.000776116,-0.014131949,0.049293872,-0.087966055,-0.0232023,-0.047407806,-0.029911637,0.015267083,-0.038385056,-0.07932817,0.059233855,-0.00032715447,-0.050686527,-0.09670925,-0.039775483,-0.048408534,0.010748851,0.029032463,-0.032700673,-0.030099243,-0.0080079045,-0.030216618,-0.05186962,-0.008329123,0.029381938,-0.052924596,-0.003376289,-0.014339665,0.03772497,-0.09093301,-0.078139536,0.055797048,-0.012517839,2.1405617e-34,0.078099474,-0.083154894,0.020357156,-0.015431667,-0.060333036,0.055204157,0.0623724,0.05991572,-0.008065102,-0.06282429,0.029264059,0.04764735,-0.046591602,0.02508098,0.06213459,-0.04174732,0.08153005,-0.0028648104,-0.0074393945,-0.023914462,-0.0107164355,0.11121172,0.0053079836,0.066774495,0.033329315,0.0134882415,-0.0066525545,0.12606692,0.048216462,0.05430781,-0.00866352,-0.0003017282,-0.0011720583,-0.030219248,-0.00057377346,0.018800955,0.017362924,0.027679047,0.020273175,0.027602332,0.0543907,0.04754885,-0.022658674,0.08873382,0.039819855,0.06549525,-0.09338157,0.06480404,-6.072954e-06,-0.079485364,0.02723222,0.015168016,0.0070829405,0.011708744,0.016921852,0.025537593,-0.095705815,0.029041205,-0.024865143,-0.03262253,-0.061770193,-0.05795599,-0.022072239,0.0909709,0.043522246,0.11921584,0.015626598,0.04104726,0.0001580887,-0.039546773,0.013514846,0.061538517,0.008762028,0.042787053,-0.03211691,-0.09262789,-0.12444888,-0.029428585,0.032120295,0.012894934,0.07025245,-0.011595075,0.04485039,-0.0013897847,0.055423234,-0.059381563,0.008847792,0.05072062,-0.016081706,-0.042131435,0.05566829,-0.05322826,-0.06897375,0.050551716,0.05328534,-2.4103796e-08,0.06509039,-0.03896992,0.064602286,-0.071876496,0.03692771,-0.035936054,0.030871606,0.03172345,0.048232924,0.019476144,-0.053302236,0.034803633,0.00808288,0.010731413,0.08179051,-0.008048053,-0.03801804,0.07278708,-0.06430141,0.04821644,-0.02056734,-0.05831319,-0.09431711,0.038570944,0.040241487,0.026489101,0.11229312,0.058671396,-0.014853107,-0.03746329,0.0109950965,0.010033935,0.023372443,0.11409967,-0.09097936,-0.021211054,-0.019098455,0.013729109,-0.007215348,0.04512985,-0.038801882,-0.00087293435,-0.08587214,-0.007066964,-0.07288698,-0.0044530104,0.01427845,-0.028969117,0.0059895664,-0.0029564328,0.03641219,-0.008441882,-0.04737044,-0.06113445,-0.12079556,-0.062297866,0.028663712,0.03431461,-0.02374537,-0.07653497,0.035300452,0.0050916667,0.121064,-0.047711354 +3.13.1.9,"The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD+ cofactor. It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine.",384,1.0,-0.07581671,-0.0109373825,-0.08202349,-0.0054376265,0.05611301,0.093350224,-0.13106816,-0.01183257,0.039997123,0.02263403,0.00062014704,-0.01730351,-0.04423895,0.05769726,-0.06825844,0.06723779,-0.09123661,0.038274787,0.0063343085,0.013934802,0.022804622,0.10049328,-0.07447599,-0.0030506144,0.07802663,-0.03596381,0.0047378065,0.010557563,-0.027543483,-0.002140649,-0.039216407,-0.051497955,0.05879614,-0.03780344,0.07400132,0.112379536,-0.0018502006,0.009002491,0.07597357,0.053877007,0.04427279,-0.013630672,0.03718678,-0.01663845,0.001540767,0.0050902693,-0.021876596,0.06500398,0.08068861,-0.05923239,-0.034941394,-0.047411256,-0.05028712,-0.013815649,0.0705179,0.0977661,-0.00979453,-0.039924305,0.01277123,-0.06797954,0.06791756,-0.073189124,0.0126065975,0.017021641,0.057615828,-0.11374856,0.04094197,-0.065225594,0.08388446,-0.019118134,-0.07748155,0.012904854,0.0063658496,0.005330887,0.0007059756,0.020685889,-0.07201084,-0.009965494,0.051732853,-0.037919763,0.077718414,0.0030742506,0.012398176,0.0019969784,0.05082523,0.013212955,-0.011344441,-0.019283134,0.035040226,-0.009885786,-0.054085173,-0.057020992,-0.028997088,-0.070149496,-0.12594071,-0.095547095,0.09487365,0.06019784,-0.06064938,0.031243365,0.025613545,0.047387417,-0.053641774,-0.06909311,-0.07792371,-0.03394664,-0.02281218,0.08913031,-0.02940463,0.061567217,0.07800077,0.020071916,0.048418783,-0.043002743,-0.024024766,0.096208245,0.0019257289,-0.05164728,-0.06833358,0.018615646,-0.040544435,-0.044585597,0.060366016,-0.011427432,-0.029550496,0.027704833,-0.021411624,5.51301e-34,0.10205022,0.018890357,-0.025810946,-0.033007536,0.041561794,-0.050279327,-0.07602073,0.058805075,0.006276843,-0.06011508,-0.032176714,-0.004171526,0.04869888,-0.011409496,-0.08479674,0.029950287,-0.015221762,-0.075008795,-0.0052038324,-0.013133188,-0.054988056,0.021113697,0.004210561,0.056879424,0.036973376,-0.05247222,0.014484627,0.021692852,-0.001240002,0.02741185,-0.01370614,-0.016154928,-0.09054916,0.023106206,0.068476014,0.016445072,-0.048345707,-0.06460597,0.008610446,-0.009594657,-0.017339563,0.03893298,-0.010819127,-0.08199271,0.0024063801,-0.011409742,0.009080799,0.1108414,0.0011910985,0.023371672,0.029078599,-0.046748023,0.05231436,-0.009277642,-0.12018604,-0.022844894,-0.0059018764,-0.09109123,0.040495373,0.09834711,-0.035275172,0.015939558,-0.006641144,0.12112076,-0.040117282,-0.0064141857,-0.09849722,-0.07104047,0.06066302,0.07947966,0.028384572,-0.0354959,0.015789134,0.07035969,-0.06786889,-0.01872686,-0.008346797,0.0147158345,0.0024371268,0.004608299,0.07304356,-0.0069080573,-0.038041428,-0.025745573,-0.029029625,0.010422449,0.0031679464,-0.04516449,-0.02819098,0.003923844,0.017624676,-0.037715834,0.011860163,0.01103194,0.052400008,-3.106811e-33,0.09488831,-0.06466113,0.021468181,-0.11920102,-0.03495138,0.12124951,-0.021656062,-0.052456595,0.018236775,-0.096395515,0.07662144,0.034468245,0.013643815,0.007973524,0.06958251,-0.07605267,-0.007335081,0.036379706,-0.014394595,-0.011383273,0.07014165,0.04733986,-0.010797832,-0.06766628,0.06253531,-0.05471541,-0.07421393,0.08617137,-0.031015798,0.10264134,-0.01639109,-0.029834244,-0.07585004,-0.016178982,-0.03837509,0.043638874,-0.034154896,-0.01409244,0.042834427,0.03785696,0.03664765,0.04103777,-0.006414585,0.10153678,0.094369814,0.068259716,-0.09551996,0.029217593,0.009396204,-0.10788671,0.018778969,-0.03594579,-0.0054825824,-0.043828893,-0.029678626,0.12645626,0.0014911464,0.011406505,-0.020446787,-0.02891191,-0.07492621,-0.07321489,-0.025982697,0.0020619412,0.041626036,0.012341481,0.010166531,0.0013224307,0.03511484,-0.013727337,0.03438978,0.059274588,0.014878678,0.0947684,-0.0730869,-0.060632717,-0.1049409,0.038719874,0.016277568,0.016568156,-0.054479882,-0.024645507,0.056901876,-0.027998703,0.008640774,-0.02403415,0.08365072,0.023633564,-0.01574961,0.019908125,-0.027006155,0.047325097,-0.06107376,0.0012743934,-0.004908807,-3.8592223e-08,0.06725413,-0.0708995,0.0108049195,-0.033840425,-0.019724773,0.05094525,0.04757084,0.052477982,0.07757711,-0.033365376,-0.006246524,0.12748209,0.0036626922,0.04589191,-0.0059974045,0.03988586,-0.05797871,0.009074254,-0.057800096,-0.046928365,-0.035076898,-0.041183382,-0.033739023,0.03880947,-0.023229279,-0.050586417,0.04072961,0.08567896,-0.049270142,-0.026232012,0.054787617,-0.052334998,0.00018259522,-0.028991073,-0.075887516,0.009226796,-0.06313336,-0.03981783,0.013837091,-0.03269714,0.040650602,0.04726431,-0.058643144,0.051287074,-0.008007775,-0.007645588,0.022277849,0.02475056,-0.07357504,-0.0036632475,0.05778131,-0.010145881,0.0120091485,-0.035547838,-0.060258865,-0.03712202,0.028043795,-0.031614564,-0.043651953,-0.01765281,0.031647954,0.03555582,0.11742208,-0.027219739 +4.1.2.61,The enzyme is a member of the enoyl-CoA hydratase/isomerase superfamily. It catalyses a two-step process involving first the hydration of the double bond of feruloyl-CoA and then the cleavage of the resultant beta-hydroxy thioester by retro-aldol reaction. (E)-caffeoyl-CoA and (E)-4-coumaroyl-CoA are also substrates.,384,1.0,-0.09527293,-0.02091989,-0.05265368,0.04088129,0.07739709,0.008401053,-0.08922724,0.0050128945,0.007632029,-0.047453832,-0.010662288,-0.110219695,-0.04829284,0.027768081,-0.036461197,-0.006729617,-0.06575677,-0.011188818,0.024871537,-0.06134516,0.064809546,-0.019248957,0.007987927,0.049964234,0.06405284,0.029504223,0.06983891,-0.036786932,-0.011931277,-0.0750858,-0.071391,-0.043756336,0.06658296,-0.041951943,-0.008824798,0.124686524,-0.012355106,-0.079617806,0.0022051106,-0.016412854,0.025625229,-0.0775297,-0.06774771,-0.0051828227,-0.05694644,-0.07508193,0.038467072,0.044653405,0.05480777,0.04814662,-0.021946609,-0.07658094,-0.076090574,0.02510546,-0.0029116496,0.023570353,0.033018507,-0.03857935,-0.0561212,0.030729542,0.08093648,-0.029722314,-0.060678568,0.06475928,0.031915113,-0.0009714968,0.02881971,-0.0049625393,0.008043335,-0.057500474,-0.0035868252,-0.053719837,-0.025362326,0.015093955,-0.022882951,-0.029739803,0.008190818,0.02406985,0.048582986,0.021328937,0.006598277,0.036214616,0.032795668,0.037025962,0.07784044,0.019972999,0.012869029,-0.025250806,0.050428122,-0.009692019,0.008851043,0.040032465,-0.051212866,-0.014890567,-0.046047714,0.033851806,0.02147509,0.036102857,-0.000108049455,-0.0031302397,-0.015468248,0.08591162,-0.008768762,-0.06177447,-0.013710895,-0.002313698,-0.030508501,0.119196825,0.016652524,0.0020190098,-0.023438876,-0.020561706,0.07156375,0.07672374,0.0023043489,0.09361044,-0.03478605,-0.016600132,-0.032040264,0.045070183,0.036381036,-0.00527826,0.040332817,0.059835,-0.0046747727,-0.036650643,-0.119110756,-1.4964095e-35,0.11889248,0.056547727,0.013512384,0.00014170031,-0.0054206667,0.011504031,-0.057777453,0.0675129,-0.10742118,0.013313523,0.0031048772,-0.040332258,0.061608575,0.03403297,0.02182704,-0.08320188,-0.009809579,0.04790479,0.06806744,0.008855197,-0.009627375,0.068322994,-0.056579348,0.016117122,-0.08775703,0.07715639,-0.014579264,0.08383172,0.05323996,0.04134516,-0.024551602,-0.08560116,-0.036071174,-0.0035269905,0.017241227,-0.055345833,-0.024936415,-0.0034629523,-0.03290155,0.12880014,0.05049468,0.0151522225,-0.026653135,-0.11204046,-0.0071206656,-0.08135297,0.0004235322,0.07685457,0.034045476,0.019902779,0.023061942,-0.027665028,0.06495787,-0.01691731,-0.056008123,0.0596017,-0.035030365,-0.014157554,-0.04196931,-0.0049722656,0.055448763,0.045839872,0.021699745,0.040580112,-0.04911149,-0.009285655,-0.06483081,-0.03558548,0.022121824,0.09107717,-0.04862557,0.05154131,0.037716955,0.05317092,0.050573125,-0.0686009,-0.041041564,-0.018430304,0.034940895,-0.0022146194,-0.034589637,0.011992743,0.04526105,0.012824698,-0.023422664,-0.015281324,0.024359781,-0.009992427,-0.047207773,0.042472117,-0.02248522,-0.03514883,-0.016886562,0.006030245,0.04002858,-1.0385691e-33,0.16306713,-0.14969102,0.04775116,-0.1657655,-0.089130506,0.029746544,0.03378828,-0.07271356,0.033457838,0.062698625,0.094949625,0.039338216,0.022191126,-0.06424589,0.02787737,0.016818695,0.031379387,-0.054530416,-0.059706952,-0.08374046,0.007009201,-0.00600798,0.061393,-0.04297101,0.023518037,0.019095832,0.017549634,0.02892032,0.021187019,0.10124692,-0.055243783,-0.05439641,-0.0055554244,0.0034166803,-0.021913636,0.08861528,-0.03630708,-0.0038862852,0.055347797,-0.0004312283,-0.017375777,0.008456362,0.03704426,-0.011777257,0.029380688,-0.013452844,-0.045516577,-0.04536614,-0.062582225,-0.085305676,0.05208412,0.007416448,-0.068298385,0.042637307,-0.046173178,0.043843176,-0.017301917,-0.01658769,-0.026056537,-0.024498468,-0.016347473,0.0073707304,0.025300277,-0.01282075,0.04851852,0.021079747,-0.08990299,0.045302123,0.023790615,0.036312066,0.102265775,-0.02913604,-0.00020118624,0.09850285,0.017482376,-0.029695706,-0.044019636,-0.045423508,-0.043235675,-0.06839313,-0.05335749,-0.02748122,-0.044005588,-0.048998185,-0.13187316,-0.11012107,0.0454839,0.09198537,0.021368638,0.042658597,-0.04835042,-0.022755345,-0.021945622,0.104548395,0.113590315,-3.9304926e-08,-0.06946413,-0.08103801,0.0025778424,0.019500341,0.009075413,0.08200782,-0.018214513,-0.05802523,0.06683638,-0.039587464,-0.0335693,0.07386651,0.049292732,0.050787583,0.0045232982,-0.012299945,0.025483608,0.025855284,-0.025145737,-0.06097181,-0.049868364,-0.009676139,-0.023491308,-0.029959517,-0.001490334,-0.049535386,0.015255156,0.039539374,-0.015639856,0.0040340824,-0.06329196,0.017919127,-0.017869491,-0.019961314,0.00058162404,0.0775751,-0.006466125,-0.012016953,-0.07081718,0.07812322,0.06791908,-0.050826743,-0.048768707,0.03496179,0.058920886,0.03793162,0.033608075,0.047199838,0.0056095663,4.0230057e-05,0.01606944,0.02081571,-0.03346105,-0.023257522,-0.06812372,0.036678616,-0.018583259,-0.06915055,-0.019051552,-0.039413676,0.046548564,0.011927516,0.19667727,-0.065637 +4.2.2.27,"The enzyme, isolated from the fungus Aspergillus giganteus, acts on the non-reducing end of methyl-esterified polygalacturonan, releasing either 4-deoxy--L-threo-hex-4-enopyranuronate or 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate. The enzyme is stimulated by divalent cations, with Co2+ having the strongest effect. It is able to act on substrates as short as a disaccharide, and was active on substrates with degrees of methyl esterification ranging between 34% and 90%.",384,1.0,0.046520136,-0.017485574,-0.06802554,-0.022960395,0.02588686,0.024553455,-0.02205384,0.0059516034,0.013717592,0.03462982,0.059686255,0.015442016,-0.07951289,0.03857401,-0.074037015,0.069329746,0.05762293,-0.0066398378,0.007589507,0.018939745,0.15603435,-0.02922932,-0.06531556,0.011910155,0.045190588,-0.01659529,0.03042973,-0.048355214,-0.06370566,-0.067909785,-0.073663205,0.005723607,0.009107837,-0.058477078,0.013120402,0.12328507,-0.067975484,-0.07940737,0.08258594,0.0083154505,0.04201353,-0.02390167,0.00073741295,-0.043197747,-0.08269481,-0.061269037,-0.014992627,-0.014715286,0.06137544,-0.038961038,-0.05605476,-0.033435564,0.028091833,-0.0020667578,0.06668503,0.06047593,-0.0067240847,-0.03816156,-0.02684966,0.025316084,0.06114373,0.018222265,-0.03873885,-0.0032928626,-0.08735942,-0.03967664,0.024424788,-0.053243652,-0.07602984,-0.018860986,-0.0388572,-0.015164541,-0.0397536,-0.04866116,0.061736703,-0.004970126,0.004679308,-0.08209875,0.05057384,0.034433126,0.071234554,0.048944864,0.05179941,-0.037563577,-0.007957663,-0.010165613,0.045156244,0.04948456,0.02245513,0.05221702,-0.00035400505,0.06650753,-0.026117891,-0.017423127,-0.023811387,0.0074343714,0.065894045,0.053688027,0.02839029,-0.032132145,0.030100422,0.0026028766,-0.04245636,-0.09687479,-0.033222407,0.003618782,0.09941727,0.086407095,0.08808452,0.017298369,-0.04433068,0.013532207,0.014773679,-0.009858268,-0.058543183,0.122853845,0.063631594,-0.032868207,-0.04818487,-0.06382538,0.049019743,0.0026118513,0.06959902,-0.008771859,-0.0062556863,0.030255267,-0.0565084,7.444544e-34,0.05082991,0.0027988418,-0.036960978,-0.034813717,0.07691002,-0.028043348,-0.034685105,-0.011447652,0.021371134,-0.01968348,-0.11026319,-0.06191566,-0.07986032,0.13655558,-0.007236535,-0.0036188262,0.062278572,0.015150704,0.04904496,0.032952506,0.020234853,0.047552064,-0.070462875,0.015614111,0.0036761279,0.018480778,-0.025640355,0.049099132,0.056738958,-0.018231371,0.02869917,-0.060709357,-0.09284286,0.017136863,0.12148099,0.02186932,-0.031247469,0.02895026,-0.023484917,-0.016962737,0.005832151,0.06382082,-0.023554822,-0.055907894,-0.030131431,-0.030502483,-0.04227486,0.056329887,0.06443326,0.019441577,0.07051997,0.0520057,0.0551658,0.0073368675,-0.043803554,0.028647197,-0.0061611854,-0.013309261,0.004339915,-0.004115198,-0.07036226,-0.033549935,0.017380392,0.05276553,0.018978596,-0.0017667308,-0.032120395,-0.045216106,0.001152657,-0.03915187,-0.062371228,-0.0086577,-0.042577468,-0.029451367,0.028543517,-0.045581512,-0.041754857,-0.051086076,0.03223731,0.0028439756,0.025686566,-0.016713394,0.03412529,-0.09158623,-0.100641795,0.028286804,-0.0075501963,0.025009682,0.0704936,0.031860135,-0.05579389,-0.06312036,-0.056256875,0.034026943,0.07480146,-3.4648343e-33,0.08369216,-0.061965317,0.0661624,-0.039315496,-0.07941115,0.12529473,0.06477836,0.03420436,-0.015934568,-0.044616297,0.06896889,0.018617569,0.010012468,0.018152753,0.0065738554,0.055341404,-0.04605504,0.11857707,-0.028137315,-0.018631684,-0.04523097,0.07353838,0.00090154464,0.051681306,0.08701087,0.0051943874,-0.02088155,0.028544217,-0.0062640863,0.041982345,0.00071311,-0.012562963,-0.036926858,-0.027208744,-0.036415078,0.062376905,-0.059359234,-0.03023688,0.007546004,0.09597612,0.0059954645,-0.013489732,0.026083844,0.090249486,0.004594821,0.015489961,-0.07422584,-0.009033725,0.0132922605,-0.03898579,-0.0033022105,0.010994472,0.032064464,-0.018591268,0.06550646,0.007590069,0.061364587,0.01037416,-0.0147434855,-0.0934823,-0.07807638,-0.020681778,-0.008657982,-0.033640217,0.05201497,0.05251426,-0.024884135,-0.048032634,0.04568131,-0.03381939,0.05684863,0.022391422,-0.06271596,0.05615233,-0.038217276,-0.01373149,-0.090883955,-0.02386621,-0.033541825,0.037257507,0.053668115,-0.0069002067,0.01798118,-0.12620723,-0.045952726,-0.11171691,0.0881073,0.04635728,-0.11406937,0.05654516,-0.015738139,0.012170462,-0.086658865,0.06478201,0.07202048,-4.9222244e-08,-0.012321673,-0.010484426,0.026729302,-0.11644945,-0.08411504,0.025439888,0.056575038,-0.029045172,0.07760177,-0.04565089,-0.060970325,0.08887104,-0.009728227,0.08968967,0.004439186,-0.058271386,-0.032064263,0.009122616,0.0093357535,0.022403784,-0.08257783,-0.036762238,-0.12748903,-0.02917766,-0.0008530613,-0.07276719,0.036535334,0.13484587,0.00031859655,0.0368522,-0.003920232,0.07915476,-0.026587468,-0.061227176,-0.06716381,0.054677695,-0.023476565,-0.048263397,0.0012846526,0.034389693,-0.0033723933,-0.04128039,-0.0211834,-0.021833578,-0.07654806,-0.02440759,0.010690689,0.060652655,0.005909897,0.035392754,0.07204931,-0.030699227,-0.051316295,-0.0681361,-0.057096753,0.011896653,0.014458657,0.025213733,-0.06784076,-0.050986893,-0.010775056,-0.018745262,0.13279581,-0.05808795 +4.6.1.24,"A family of related enzymes found in some fungi and bacteria. The enzyme is specific for cleavage at the 3'-phosphate group of guanosine in single stranded RNA, and catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides.",384,1.0,-0.093720436,-0.08217918,-0.048693273,-0.06609189,0.06491143,-0.01368353,-0.05633792,0.013157624,0.0045439242,0.08378884,0.076689035,-0.012543767,-0.0808648,0.065062135,-0.09355358,0.07577145,-0.13682438,0.013324261,0.029822998,-0.030566059,0.12903397,0.044170085,-0.048670825,0.020295257,0.011015167,0.0041803312,0.041005265,-0.037581626,-0.04273636,-0.055860296,-0.041147612,-0.0684059,0.027912538,-0.0156140365,0.026251767,0.14111282,-0.038878154,-0.024492506,0.02209146,0.064675674,0.036830936,-0.04984223,-0.0140002305,-0.034917217,-0.0262461,0.017263256,-0.037557736,0.09161493,0.021213526,-0.036781102,-0.045035247,-0.082990125,-0.060613383,-0.028736822,0.0138362115,0.009969425,-0.06427764,-0.008042117,-0.0068763196,0.03336302,0.044540837,0.007336796,-0.07873461,0.026949182,0.039120656,-0.02767253,0.038747005,-0.039113805,0.020620322,0.043107823,-0.005361603,-0.055548552,-0.041466005,-0.014892267,-0.03194315,0.09239347,0.025797302,0.009550181,-0.0028872106,-0.02714193,-0.0062022065,-0.014473246,0.07868926,0.014067848,0.031527344,-0.02838274,-0.039186284,0.039212763,0.021102447,0.018563231,0.046519443,-0.010659112,0.02909021,-0.03153773,0.009494856,0.08485653,0.011364304,-0.03083575,0.053054936,-0.025389388,0.014104292,0.035190515,0.038474914,-0.124087624,-0.022646504,0.05249055,-0.0058819978,0.031322565,0.009407163,0.032511063,-0.058814917,0.05373369,0.032337196,-0.047167785,-0.014047012,0.07570604,0.03479391,-0.038340237,0.0022016086,0.062243585,0.050116543,-0.02478711,0.006678394,0.02205615,-0.06150841,0.07442404,-0.09611468,3.9661205e-33,0.04471463,-0.006344025,-0.031613104,0.017585186,0.00848538,0.02278465,-0.091335975,-0.02179005,-0.07460742,-0.022819417,-0.07069023,-0.026430702,0.0206167,0.0016558457,-0.029962115,0.012545506,-0.020360496,0.027952867,0.034842264,-0.018715877,0.00019087225,0.020051897,-0.04583384,0.037195522,0.030837156,0.03715614,-0.031305574,-0.031958945,0.013574866,-0.022071222,0.00779466,-0.06998559,-0.07065399,0.04448552,0.07463786,-0.027968239,-0.025336383,-0.036072697,0.05678233,0.06967262,-0.03687093,-0.015525495,-0.040886953,-0.014266023,0.08732984,-0.031704765,-0.062212277,0.043082546,0.031123603,0.02312762,0.08211261,-0.031674024,0.036370352,0.050367873,-0.031926997,-0.02899544,-0.008128171,-0.045910507,0.01767535,0.0056941495,0.036803823,0.09786946,0.013970494,-0.016205993,-0.031599317,-0.018649712,-0.08642372,-0.08495143,0.012905795,0.10194758,-0.06529967,-0.054274894,0.05572005,-0.019924736,0.027254572,-0.058905374,-0.013798529,-0.011529118,-0.017104756,0.096557416,0.010563079,-0.008311548,0.060423132,-0.011234558,-0.06847492,-0.024017168,0.010178147,-0.12756678,-0.031198662,0.06818476,0.023135178,-0.05414402,-0.0031016038,0.0025870402,0.025714053,-5.7613447e-33,0.12331312,-0.09650774,0.07765904,-0.06757982,-0.105770975,0.019513406,0.0073280153,-0.0644076,0.023388596,-0.050420657,0.017365213,-0.016238747,0.022712376,-0.020493038,0.013768517,-0.0112625025,0.07221935,0.107687466,-0.0016319975,-0.010455769,0.07666498,0.10700188,0.0357365,-0.008475333,0.0974303,-0.032922566,-0.005416537,0.056338735,0.008187259,0.058662776,-0.075307585,-0.03332642,0.028480079,-0.0062919594,-0.008391148,0.040550143,-0.055366043,-0.0036490066,0.046219844,0.0051008696,0.033995632,0.003758117,0.07647526,0.028413864,0.03738904,0.06541835,-0.038323693,0.009395073,-0.07668815,-0.09520474,0.04950626,0.012363963,-0.047346793,0.067697816,0.0031429164,-0.0457276,0.018811464,-0.0060134013,-0.036141705,-0.0037109207,-0.048253063,-0.11207356,-0.022691183,-0.04730556,0.06061872,0.07547747,0.00476996,0.07545895,0.041357435,-0.041741896,-0.021895856,0.015257442,0.021431925,-0.010012575,0.025128715,-0.011311229,-0.09014301,-0.07732189,-0.0011127075,-0.09520672,-0.029478563,0.0039955894,-0.0046244133,-0.046341103,-0.001206663,-0.12089035,0.08682487,0.1060957,0.00057777826,0.041858673,0.003819419,-0.010769935,-0.00018721618,0.08144094,0.104857326,-5.0960793e-08,0.032466453,-0.03231059,0.04372563,-0.07773919,0.036496934,0.034679525,0.03940926,0.06491305,0.07005312,-0.034495506,0.000928573,0.07217821,0.031283237,-0.018621955,0.117067695,-0.002542114,-0.09054883,0.013855549,-0.026645709,-0.031734515,-0.060292754,0.022194492,-0.14872591,0.06170776,-0.043023523,0.007849279,0.05477606,0.008436012,-0.022551652,-0.02447416,0.021093696,0.021540085,0.0055074035,-0.004988889,-0.045554858,0.031875305,-0.031808227,-8.4072875e-05,-0.0049060755,-0.007844941,-0.054673992,0.017022297,-0.06741487,0.03818412,-0.07636439,-0.038107548,-0.019744813,0.027332675,0.017971871,0.04823167,0.07608263,0.017691195,-0.028918415,-0.062222004,-0.09448648,-0.08206631,0.020994416,-0.09101632,-0.054917984,-0.020100476,0.010110299,-0.013589828,0.20396382,-0.017282546 +4.6.1.25,"The enzyme from bacteriophage T4 cleaves early mRNAs between Ap and Gp at one specific specific GpGpApGp site, favouring their further transition to middle-phase mRNA. The activity is enhanced by Ribosomal S1 protein. The enzyme catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides.",384,1.0,-0.034757745,-0.07583804,-0.012941705,-0.06412071,0.009359174,0.03019883,-0.041969977,-0.009455052,0.03904296,0.08325601,-0.013025954,0.047616243,0.0094778715,0.08851906,-0.030589778,0.08843232,-0.10924848,0.022271493,0.014695272,-0.07881044,0.100621946,0.042347886,-0.025218677,0.053193536,0.008631427,0.024286104,0.029016802,-0.034618225,-0.019203283,-0.022789065,-0.031791992,-0.06357071,0.04903238,-0.050690047,0.014102526,0.096349366,-0.022801243,0.014413241,0.04775935,0.033983655,0.04500087,-0.006365518,-0.021808013,-0.016537461,-0.016089976,0.011508932,-0.016010677,0.10445282,0.060892742,-0.053420257,0.00060044066,-0.062289406,-0.05601495,-0.078407824,-0.020826446,0.042541496,-0.063544564,-0.018343762,0.049873885,0.008819926,-0.015486358,-0.021109017,-0.06638319,0.06417318,0.053735908,-0.04408484,0.024024758,-0.04288203,0.0051426413,0.017176012,-0.034484707,-0.03632393,-0.06341128,0.0014924766,-0.0067725433,0.065870434,0.02954741,-0.029327085,0.0024637387,-0.024183393,0.017039137,-0.06829147,0.05441049,0.063131995,0.011541085,-0.007567066,-0.0006422393,0.032537833,0.017426087,0.026315918,0.021915443,-0.023876501,0.03245362,-0.013965258,0.0318417,0.029844845,-0.03520491,-0.022947408,0.06764019,-0.03199018,-0.033865444,0.03718803,0.0232042,-0.07758134,0.014201282,0.027279086,-0.0066009965,0.08750696,0.0038941156,0.036389288,0.034632377,0.005094676,0.058110345,-0.03718091,-0.013382145,0.08148855,-0.015411412,-0.026105661,-0.03457525,0.005489895,0.045243654,-0.057111263,0.019231087,0.01392627,-0.051504042,0.05346079,-0.08247956,4.65635e-33,0.08152781,0.0030325805,0.02789449,0.05503613,-0.01706927,0.038079344,-0.07041527,-0.052620538,-0.058803596,-9.902986e-05,-0.060528956,-0.05090136,0.04928221,-0.0009943071,-0.023131264,-0.067564145,-0.009965131,0.03874542,0.044989757,0.011859445,-0.02515482,0.051526416,0.00031629755,0.05433247,0.042403854,0.07157497,-0.019329159,-0.045265075,0.039138597,0.00740968,-0.02895615,-0.059802204,-0.11869084,0.028237231,0.037437037,-0.04525764,-0.030698106,-0.026497625,0.07228728,0.08949715,-0.013713457,-0.028630447,-0.048513047,-0.033266466,0.09524284,-0.024246834,-0.064492725,0.075092375,0.00021792538,0.094894394,0.08970845,-0.02118436,0.052854214,-0.021446042,-0.10118546,-0.005120595,-0.00813264,-0.0437564,0.039520577,0.030151507,0.03792252,0.09865713,-0.026384076,0.00079555146,0.019005414,-0.019312356,-0.044137105,-0.120190725,-0.025209567,0.105331436,-0.0047011054,-0.037819155,0.07405052,0.014863454,0.035001397,-0.01297595,0.014232141,-0.0023414118,0.013980887,0.050699074,-0.011262731,0.007222781,0.066620715,0.015142324,-0.021768877,-0.06717594,0.028301278,-0.095719986,-0.040009532,0.039858826,0.005525997,-0.07043926,0.006054555,0.07692595,-0.014886315,-5.5963045e-33,0.095277056,-0.0971465,0.09061555,-0.04656826,-0.13453871,-0.014971891,0.061865434,-0.051889762,0.07183006,-0.028313741,0.037498888,-0.0120311845,0.0014297307,-0.03983097,-0.0039466405,-0.05100973,0.07816651,0.07789142,-0.066615246,0.026350372,0.068852976,0.082063764,0.02072994,0.03994257,0.09055596,-0.021935083,0.036703125,0.04010893,0.028053664,0.053791817,-0.016337836,0.0027632834,0.04155204,-0.013836975,-0.055125985,0.07513966,-0.040267516,-0.0035189649,0.044908,0.027370257,0.016083393,0.03425217,0.07706712,-0.00985618,0.04216729,0.054856867,-0.01613542,0.047143236,-0.06669759,-0.095357455,0.017899191,-0.018899657,0.0018402206,0.048186414,-0.0194445,-0.061141253,0.031086303,0.012016969,-0.033061095,-0.07559105,-0.023423608,-0.09729218,0.03287824,-0.0036823696,0.040855337,0.061251212,0.01127267,-0.032808404,0.0138949165,-0.0869378,-0.03990028,-0.030710567,0.020718686,-0.029295601,0.068768755,0.024405438,-0.109051034,-0.11107107,0.0017999621,-0.07699638,-0.09129081,0.020609193,-0.01647235,-0.04512396,0.04475946,-0.13399495,0.0077680172,0.10464166,0.04842675,0.03749884,-0.0005640896,-0.0016307931,0.043928374,0.07375533,0.06624799,-5.021612e-08,0.036610186,-0.032518413,0.044970818,-0.040540874,-0.01571862,0.028992867,0.007763252,0.012227003,0.08163445,-0.12013134,-0.018007845,0.011243697,-0.024111746,-0.040211026,0.08945096,0.030768152,-0.11619008,-0.033870343,-0.02433254,-0.0754675,-0.11268166,0.0013361872,-0.11518283,0.032184925,-0.058596212,-0.010454718,0.03430595,-0.01848936,-0.0077338414,-0.06143701,0.060537327,0.020169966,-0.062031668,-0.02044456,-0.061963286,-0.021059193,0.005302192,0.04268244,0.02846346,0.065347396,-0.0019307986,-0.03152707,-0.041781306,0.020855663,-0.08689992,-0.02357932,-0.06005956,0.052757066,-0.011869485,0.00735296,0.09229487,0.0015799735,-0.064757906,-0.08005637,-0.063057795,-0.050041378,0.006754986,-0.1109122,-0.03303208,-0.02600654,-0.042118005,0.012062636,0.17799082,-0.06260937 +6.2.1.62,"The adenylation domain of the enzyme catalyses the activation of 3,4-dihydroxybenzoate to (3,4-dihydroxybenzoyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein domain. The aryl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0,0.0116957845,-0.10106906,-0.09596809,-0.077442214,-0.027275458,-0.03650233,0.038112637,0.019140556,0.08654751,0.02866646,0.05059497,0.010189438,0.0014025603,0.051600773,-0.02567658,0.06679857,-0.07420257,0.008490782,0.040382337,-0.05392986,0.024197478,0.046412207,0.0022092275,0.015021837,-0.0042984663,-0.028717795,0.042220607,0.028480724,-0.008514631,-0.041932736,-0.0015741369,-0.010908984,-0.013686555,0.025065228,0.06633556,0.12400465,-0.050223738,-0.067512885,-0.022128128,-0.0014138807,0.05574544,-0.059120238,-0.012641972,0.01999219,-0.05650374,0.06563727,0.018467888,0.14464271,0.10040769,-0.030536816,-0.022331849,-0.08258,-0.00822028,-0.009956086,-0.10547403,0.095898256,-0.043384437,0.014490955,-0.048871398,0.021051401,-0.05502119,0.0007580897,-0.04286156,0.017081091,-0.0016249404,-0.06605993,0.023030207,-0.002819049,-0.032315068,0.011791924,-0.01545952,-0.070178926,0.0032159411,0.0024185898,0.032531768,-0.04104381,-0.030251639,0.0026302438,-0.017204938,-0.04899489,0.063623555,0.0031902683,0.07130445,0.06906833,0.010843166,0.04636663,0.0063059996,-0.030849248,0.022648528,0.0029643006,0.032887224,-0.06381413,0.044472504,-0.015189432,-0.04908425,0.012833623,0.072994485,0.0075631156,0.008619435,0.02440085,0.043869097,0.015414958,-0.053508226,-0.05970789,0.00019151675,0.04153106,-0.012373337,0.113777556,-0.08968086,-0.017285455,-0.052134592,0.03771787,0.08495057,-0.013998567,-0.0010073378,0.061150454,0.004220885,-0.08182564,-0.011162099,-0.070877306,-0.0690788,-0.01636208,0.05503504,0.0399128,-0.03152614,0.023266224,-0.096754625,2.2009804e-33,0.059604745,0.07939386,0.060581274,-0.033896513,-0.04336496,0.037128445,-0.054576788,0.023202177,-0.011605683,-0.0054036467,-0.09025395,-0.039877135,0.061252676,-0.054374494,0.068104275,-0.026093928,-0.05785589,0.12907511,0.08656136,0.060423113,-0.04428917,0.026453227,-0.03764029,0.034037817,-0.013194426,0.04482451,-0.06844174,-0.045154177,0.013735164,-0.0070432443,-0.07583158,0.009008176,-0.07340069,-0.0083501125,-0.003937144,-0.039365105,-0.017628364,-0.04279256,0.0446229,0.019987417,-0.035531353,-0.060511824,0.002078506,-0.092801556,0.04306059,-0.04349958,-0.0015046493,0.06443073,-0.0532086,0.06324733,0.0668257,-0.030587804,0.15293016,-0.057813212,-0.05690985,0.016466824,-0.047550265,-0.054571934,0.01413528,-0.010017645,-0.016796676,0.015567448,-0.060476728,0.0071441447,-0.07439543,-0.035596162,-0.03424072,-0.13511434,-7.8226985e-05,0.15924773,-0.030441387,0.0070956848,0.057243437,0.028598096,0.03904228,-0.02437257,-0.10440829,0.009430597,0.0038083703,0.044044763,0.011311029,0.01722135,-0.015826678,0.0122442935,0.021779438,-0.0037268556,0.07429031,-0.03692686,-0.07078758,0.026404396,0.058307093,-0.06486977,-0.074075826,0.03664414,0.06736183,-2.8813659e-33,0.13309883,-0.085923344,-0.019253552,-0.047517084,-0.029343037,-0.0007434061,0.006052613,0.0027485646,0.042061336,-0.0072911545,0.046307106,-0.011063688,-0.06575615,-0.06282883,0.03838024,-0.057361193,-0.020568041,-0.01029261,-0.0055820504,-0.03195293,-0.012628205,-0.002558185,0.012667392,0.07849198,-0.033629395,-0.03342272,-0.034497492,0.06482078,0.048456844,0.073786855,-0.070571005,-0.04355614,-0.03334259,0.052522015,0.00045975164,0.09299755,-0.046942167,0.05514737,0.03669456,0.036148794,0.01888664,0.036626406,-0.0072446493,0.04266588,0.029494794,0.13003859,-0.043210596,0.06806303,-0.0023383747,-0.13832276,0.073228374,-0.033708643,0.10522653,-0.003685436,0.023957761,0.055941656,0.0292064,0.00010040117,-0.018564213,-0.020249698,-0.050143216,-0.07433487,-0.0056332285,0.030847216,-0.021462265,0.022638693,-0.06640887,0.071808085,0.02519135,0.042882115,-0.0028196482,0.02183378,0.0055913776,0.042872015,-0.004906746,-0.028329004,-0.0142785115,-0.06951101,-0.030510478,-0.061368946,-0.004904911,0.004161636,0.004569918,-0.018002264,-0.02554115,0.035841465,0.052862868,0.084136784,-0.051875748,0.048219334,0.025414892,0.07010744,-0.00024366305,0.007955717,0.0011406556,-4.0388887e-08,0.052146003,-0.008096192,0.0083394395,-0.11694,-0.03836577,0.050115053,0.0380942,0.018381437,0.03268114,-0.008721289,-0.03302894,0.059595592,0.006319328,0.0882776,0.01670945,0.061003078,-0.040552463,-0.008254294,-0.019371504,-0.09171657,-0.03777309,0.07407556,-0.09221063,0.034107808,-0.00067567354,0.02608838,0.04964297,-0.00524799,0.015813634,0.037508287,0.084786974,0.0049111303,-0.024701158,-0.0033603737,0.0076676304,-0.0032471775,-0.021925973,-0.027777705,-0.034663383,-0.03332116,-0.018794674,0.04622338,-0.07697291,0.005022179,0.014226673,0.040392436,0.03809938,0.042069715,0.041151196,-0.038136095,0.017380198,0.020043552,-0.010964661,-0.098089926,-0.09299085,-0.031197181,-0.056249756,-0.14520165,0.020473719,-0.082648665,0.015351646,0.016215377,0.16938727,-0.0047292616 +6.2.1.63,"The adenylation domain of the enzyme catalyses the activation of L-arginine to (L-arginyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0000001,-0.013808785,-0.11174744,-0.092641406,-0.050820585,0.007901811,0.03408957,0.02590784,0.03270907,0.11602676,0.03893782,0.03135209,0.029283727,0.0444361,0.043641057,0.022506505,0.033113673,-0.119230054,-0.042200547,0.025538657,-0.08548068,0.041353427,0.055971064,-0.0340677,0.020681042,-0.0027085736,-0.040712576,0.016107144,-0.0021026898,0.013852203,-0.041591655,0.008569456,-0.027357772,0.0078389095,-0.009870234,0.061056547,0.09671207,-0.04368556,-0.040806543,0.049608726,-0.013847718,0.04475533,-0.057588164,-0.038832236,-0.0014244792,-0.029851243,0.06518878,0.011155533,0.12600824,0.028269336,-0.01319174,0.013374954,-0.06039574,-0.058353614,-0.04967123,-0.09460286,0.12227572,-0.086797096,0.00090853614,0.038510848,0.013094767,-0.05375622,0.03652255,-0.012257926,0.009438086,0.0015178843,-0.113921225,0.019768575,-0.005092422,0.02093011,0.032245565,0.017837774,-0.082245104,-0.03752595,0.06666597,0.07377571,-0.042156424,-0.027815398,-0.01600001,-0.043408737,-0.027546309,0.060668647,0.01224189,0.05705502,0.053095207,0.010685232,-0.007320065,0.008149325,-0.023457825,0.025046488,-0.038022634,0.067933634,-0.117019184,0.038141295,-3.942808e-05,-0.03141459,-0.04252792,0.031242058,-0.048565928,-0.034232043,0.010763002,0.0038285188,0.009030333,-0.04286012,-0.04548599,0.025012363,0.044568814,-0.014072528,0.08541068,-0.027754148,-0.035222262,-0.020065231,0.03878659,0.056315906,-0.03897316,-0.0022015453,0.0649851,-0.01850646,-0.08122285,-0.0069501884,-0.07111205,-0.053851467,-0.010164654,0.028578568,0.101435274,-0.063683726,0.0153057035,-0.07060577,2.2458369e-33,0.036596306,0.014801854,0.06924496,-0.012597733,-0.07563435,0.04421381,-0.036135387,-0.00954061,0.0761748,-0.01767386,-0.069669604,-0.02702665,0.03258217,0.003243702,0.011466586,-0.010360019,-0.08014892,0.109106086,0.05674676,0.07289941,-0.097964965,0.0731619,-0.011854842,0.034152772,0.02942092,0.04643876,-0.017995415,-0.056160636,0.0430136,0.015792113,-0.058185425,-0.0067262077,-0.06636541,0.013444789,-0.026943954,-0.023879973,0.018358536,-0.032098074,0.056903433,0.042136353,-0.062696114,-0.03966454,-0.027497817,-0.058173873,0.00823375,-0.03368691,-0.013376331,0.06680185,-0.098266155,0.04746877,0.06611495,-0.04585759,0.115733944,-0.04847787,-0.048286527,0.017772386,-0.04171823,-0.046501964,0.035115924,0.03341409,0.07206019,0.0051405304,-0.0020052146,0.006543896,-0.058190342,0.01864497,-0.044348467,-0.1441246,0.016456174,0.1611228,-0.04301367,0.076246314,0.08679145,0.022180822,0.038870454,-0.026094398,-0.0924803,0.044731274,-0.023435146,0.06239202,-0.0034050385,0.013080093,-0.011702852,0.02500529,0.04604215,-0.0687492,0.06659875,-0.058873966,-0.060144298,0.016101155,0.00567625,-0.008134979,-0.049262132,0.09992592,0.025814898,-2.7432947e-33,0.104106694,-0.13524346,0.012853267,-0.050711,-0.084102534,0.019904647,0.041627564,-0.02440906,0.017931398,0.0085841175,0.021402236,0.014960015,-0.076780766,-0.052143294,0.04937218,-0.06292259,-0.030309744,2.933463e-05,-0.045411386,0.017761888,-0.07121271,-0.030488737,0.0028160936,0.060946416,0.0005717603,-0.012026943,-0.09029119,0.03471,0.019025218,0.014887508,-0.04280519,-0.07175598,-0.046736386,0.012495101,-0.031783286,0.08594071,0.008523179,0.063288175,-0.0046065827,-0.030537937,0.030507995,0.050308812,0.012393432,0.05329798,0.022789078,0.08012914,-0.004301998,0.02989278,-0.008045659,-0.120047614,0.052714214,-0.070693046,0.11298549,-0.018369297,-0.0069015995,0.026699051,0.033850163,0.038033273,2.0863677e-06,-0.0006883756,-0.030368397,-0.07781967,-0.036302082,0.024613528,-0.0036314847,0.024486603,-0.038218554,0.058952708,0.025396833,0.034092613,0.054229997,0.0125262765,0.059096165,0.036191948,0.023383018,0.0073751067,-0.0054147085,-0.124598,-0.023102168,-0.09993533,-0.027187534,-0.0340488,-0.027604898,0.0014390829,-0.03368922,0.059008136,0.041887093,0.089080624,0.01802532,0.05037558,-0.010691663,0.023694664,0.010405302,0.00811161,0.043182116,-3.7350674e-08,0.035002884,-0.0034093566,-0.009792411,-0.06397779,-0.042851273,0.069881715,-0.011049531,-0.028429946,0.02496113,-0.020938972,-0.03867638,0.05405803,-0.015396634,0.045903116,-0.011335392,0.09061049,-0.031000938,0.049263258,0.024996,-0.039143797,-0.06660476,0.0865926,-0.05967581,0.0053454475,0.010671856,-0.019816522,0.08108405,0.024216287,-0.010249674,0.011746364,0.08953467,-0.008151886,-0.06626855,0.0041032983,0.02637667,0.008065436,-0.01088796,-0.024095323,-0.024191614,-0.015847828,-0.049146336,0.06874946,-0.047156252,-0.030177271,0.014017386,0.057945978,0.03889702,0.015590334,0.024531636,-0.0063620848,-0.003931867,-0.015176359,-0.003956145,-0.088190995,-0.084284246,-0.025537513,-0.07581323,-0.1332182,0.07290812,-0.07993822,0.0002329073,0.042818278,0.16966502,0.013396253 +1.1.7.1,A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3].,384,1.0,-0.06907112,-0.023145871,-0.12657845,0.07482583,0.10755122,0.042158246,-0.031624015,-0.02992938,0.033203676,-0.10076052,0.005307705,-0.08132206,-0.05056391,0.043426752,-0.056366142,0.015048012,-0.076353565,0.051674634,-0.04610038,0.027773201,-0.015193117,0.017076543,0.06714073,-0.035013665,-0.022755431,0.06332553,0.018104738,0.007242063,-0.045353867,-0.05199831,0.026976315,0.06269474,0.10395057,-0.04496208,0.020652536,0.12108872,0.058719486,-0.07284266,0.059703782,-0.0077745942,-0.017800253,0.040002495,0.06497306,-0.05912605,-0.032403074,-0.031086935,0.03956162,0.001344222,0.06745792,-0.028710729,-0.018262137,-0.012867507,-0.059418175,0.09676068,0.03130689,0.039594214,0.0040151994,-0.060381737,-0.02043021,-0.057849463,0.018116111,-0.027221933,0.0577145,0.021590404,-0.040724438,-0.030504832,0.018714417,-0.055548307,0.016620805,-0.04971099,-0.057072133,0.0048461403,0.039297197,0.00248031,-0.04206613,0.132539,0.08083786,-0.024758276,0.08603601,-0.04254145,-0.046625346,-0.041764736,0.019476626,0.057264473,0.038904272,-0.060692433,-0.067688115,-0.040051516,-0.0064017135,0.07715982,-0.0053675426,0.061433617,0.04015165,-0.038941078,-0.08650022,0.0121005075,0.079630956,0.010412332,-0.0019408691,0.02986698,-0.034197524,0.07901045,0.01630324,-0.077478126,0.0013048087,-0.06511091,0.005508334,0.14096247,0.041014344,-0.0023390993,0.05276205,0.0070140064,0.097576715,-0.037314914,0.020169467,0.05074196,0.02880318,-0.034906045,-0.08801169,0.018787337,-0.00920084,-0.027454816,-0.012247829,0.019567335,-0.02967625,-0.050250784,-0.11021228,1.2173591e-33,0.15336554,0.017652404,0.045663424,0.028510517,0.018483307,-0.042201377,-0.11331087,-0.0188246,0.047904104,-0.07921546,-0.06752469,-0.040650077,0.10827741,-0.074381545,-0.014640739,-0.0659485,-0.10349426,-0.066079274,0.09590782,0.005479215,0.023366094,0.033947416,0.036292233,-0.024409203,0.045581974,0.07985806,0.00027851897,-0.026479715,-0.02932176,0.029066611,0.046681676,-0.07182556,-0.1100536,-0.00463579,0.028536186,-0.007303733,-0.036626957,-0.057095442,-0.053264983,0.02513635,-0.05705691,0.022723725,-0.009484558,-0.05815248,0.054359585,-0.008803252,-0.03229969,0.10016882,0.05483258,0.08366135,0.0003355423,-0.08009572,0.07853339,-0.005582501,-0.07576397,0.04463441,0.01510253,0.028895756,0.00690385,0.056256086,0.03888451,0.06367863,0.0054481025,0.054116517,0.0073727528,0.026569998,5.4171967e-05,0.0011610201,0.030212425,0.07134756,-0.03343089,0.03140763,0.066086106,0.037417307,0.008180798,-0.012666191,-0.024064535,-0.10784567,0.02102418,0.005084276,-0.0032141444,-0.060313065,-0.013490267,-0.06996314,-0.049845338,0.015691128,-0.046736106,-0.0035542916,0.0035799479,-0.027680121,0.045554847,-0.049039878,-0.03777978,-0.034225855,-0.08391912,-1.6192683e-33,0.07593646,-0.06657753,0.017957706,-0.038159117,-0.07759849,0.02403704,-0.049793337,-0.014889084,-0.010494281,0.05180087,0.07277585,-0.0027306953,0.052195348,-0.075740695,0.053766843,0.033738866,-0.0028911717,-0.032929804,0.046054825,0.034631435,0.016126297,-0.011615222,-0.018031046,-0.009050386,0.045984533,0.049588483,-0.0539221,-0.014991827,0.0659604,0.03491059,0.012420815,0.001129993,-0.063220546,-0.11067177,0.006671354,0.010683831,-0.026216025,0.009893929,0.034670103,-0.041199222,0.025295142,-0.0068961177,-0.009907281,0.09094589,0.049297504,0.03828926,-0.08722759,-0.00018167218,0.004659289,0.026219044,-0.035483822,-0.014930716,-0.060023423,-0.007467975,-0.019724192,0.050992932,-0.0036713092,0.045006145,-0.0061964137,0.011354249,-0.042455703,-0.104545094,0.06771285,0.04553643,-0.013088258,0.08692113,-0.007829571,0.061701357,0.031403515,0.0013228715,0.013211673,-0.017029025,0.045629468,0.069824636,-0.008454787,-0.013182628,-0.0036498504,-0.0015489627,-0.0050558057,0.051770743,-0.023691181,0.015710842,0.010445677,-0.067136176,0.045625374,-0.10527946,0.011586765,0.08800464,0.02809275,-0.0064781657,-0.025374418,-0.022245936,0.0059594726,-0.04923696,-0.026202017,-3.133544e-08,-0.0523862,-0.056455627,0.050823133,0.0081728045,0.040697,0.07061488,-0.012574526,-0.016306683,0.021736568,-0.004480815,0.060495418,0.10534764,0.011468093,-0.054098807,-0.0016978876,0.08589964,-0.08697725,-0.0522401,-0.029730389,-0.014841867,-0.04926734,-0.040082775,-0.11596683,0.12259476,0.06570559,-0.05505872,-0.025150286,0.006420184,-0.013784955,-0.072116226,-0.020760652,0.034583762,-0.013268809,0.003353368,-0.09880977,-0.027235914,-0.034320466,-0.058587674,-0.0309236,0.041109987,-0.039759647,0.020903436,-0.061809774,0.009547141,0.03767901,0.0678545,-0.03206247,0.06595854,-0.012000275,-0.015967347,0.04031702,-0.049091995,0.0072841304,-0.0059516286,-0.13599904,0.08299587,0.012675742,-0.017840475,0.06359027,0.03049333,-0.017164806,-0.018341182,0.0763942,-0.059434664 +1.3.1.124,"This enzyme, characterized from eukaryotic organisms, catalyses the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (3E)-3-enoyl-CoA. The best substrates for the enzyme from bovine liver have a chain-length of 8 or 10 carbons. Mammals possess both mitochondrial and peroxisomal variants of this enzyme. cf. EC 1.3.1.34, 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing].",384,1.0,-0.02279804,-0.008423033,-0.054579385,-0.04070583,0.086291775,-0.022703025,-0.11762044,0.05699089,-0.003254547,0.008055945,0.032397702,-0.08359285,-0.03483731,0.027790578,-0.032965563,0.049527675,-0.059767127,-0.0069555687,0.040496755,-0.060103945,0.042055607,0.0050280537,-0.04270817,0.0116337845,0.07327864,-0.06004483,0.052502025,-0.031176748,-0.02601984,-0.092110544,-0.029040623,-0.09898786,0.037805256,-0.046782963,0.025824595,0.028082995,-0.021126892,-0.044897288,-0.043820996,0.012805011,0.03802568,-0.0004583397,-0.033654355,-0.009730121,-0.03526304,-0.045797385,-0.008254322,0.0053244717,0.056378216,0.008914034,-0.014386512,-0.04952032,-0.101873584,0.039387535,0.029647194,-0.03364582,-0.03007381,-0.04536072,-0.03489873,0.04497308,0.053510033,-0.032641765,-0.011207257,0.0057582725,0.062178604,0.0072750337,0.06552888,-0.08906334,-0.08198269,-0.074454986,-0.028707948,-0.08626556,-0.02926863,0.04205767,-0.048604097,0.019851215,0.02050423,-0.00835904,0.043150652,0.021649744,-0.029111238,0.030591452,0.012236274,0.04890808,-0.002099759,0.02949943,-0.06954513,-0.055754907,0.009076506,0.025439397,0.0007217288,0.027009757,-0.05168517,-0.029772714,-0.050770823,0.119257964,0.032204606,0.09271498,0.030147485,-0.019559916,0.053721573,0.052042913,-0.052139007,-0.07763076,-0.039409675,0.018053818,0.009435419,0.08571983,0.036250524,-0.0039750314,-0.00095216086,0.007881023,0.016497081,0.049987305,0.0038439466,0.13328399,0.03885339,-0.054738645,-0.029194677,0.06968134,0.00925276,0.08311404,0.10404746,0.020711517,0.077334344,0.014375806,0.004578613,1.1759024e-34,0.060156345,0.051562414,0.014788248,0.05676578,0.038291913,0.040361002,-0.10899055,0.08519068,-0.04389736,0.015040134,-0.056512907,-0.022044849,0.064973935,-0.001268458,0.042447828,-0.07543664,0.043263085,0.023027163,0.075835004,-0.023925764,-0.03268216,-0.020491883,0.0011130531,0.0298866,0.03040742,0.010489201,-0.029690582,0.02372251,0.054152854,0.007496426,-0.025707189,-0.080151394,-0.062436897,-0.042761423,0.0029238518,-0.095727175,-0.08962671,0.0075935987,-0.06844804,0.08904277,0.085480355,0.021655718,-0.0012562561,-0.05968933,0.0608694,-0.09667537,-0.0068661794,0.0627916,0.034008022,0.034209084,0.06600888,-0.011686824,0.09140613,-0.033445522,-0.018923176,0.057281587,-0.00096344843,0.021154564,0.027416516,0.01205366,0.075973965,0.09435202,-0.021263652,0.061257318,0.08987976,-0.008354752,-0.07596068,-0.07705002,-0.05102479,0.052058462,-0.009349088,-0.0341213,0.055862047,0.0048444057,0.014573826,-0.07189228,-0.03561605,0.022348389,0.041003473,-0.03232423,-0.05626477,0.054100413,0.008702047,-0.05797409,0.0053816065,-0.036010396,0.011351111,-0.04890786,0.020151978,0.04245049,0.054018125,-0.082186274,-0.08780603,-0.064850144,0.062278397,-6.198529e-34,0.08714435,-0.093688786,0.019191371,-0.12771246,-0.026142238,0.015828038,0.017719077,0.037919175,0.08261942,0.020293912,0.14283884,0.007080726,0.031646647,-0.021672467,0.07905703,0.03638082,-0.021148441,0.026870966,0.025189621,-0.08461343,-0.0032064659,0.048698977,0.017528579,0.027294818,0.053211227,0.016805813,-0.048190203,0.004472778,0.06049127,0.0030744644,-0.05902474,0.010270043,0.047156412,0.06768793,-0.00021976796,0.035835765,-0.037241023,0.051431324,0.040898446,0.03843051,-0.074002,0.0847223,-0.024313841,-0.015553201,-0.0107312985,0.00028277287,-0.10706204,-0.028281897,-0.0046452265,-0.060225304,0.029839678,0.01928798,-0.06403475,-0.046641305,0.007979469,-0.005455815,-0.026061997,0.013025925,0.052066643,-0.08561679,-0.050618485,-0.034621373,0.028278181,0.0013174873,0.07986493,0.05949452,-0.08035326,0.018222146,-0.040040366,-0.016736813,0.037851214,-0.019255556,-0.05439082,0.05051429,-0.026081732,-0.03585189,0.015304618,0.004184791,0.003434258,-0.07041414,-0.029097645,-0.08046695,-0.008221649,-0.014600412,-0.09514988,-0.1463069,0.00987375,0.124583185,0.05023219,0.000798255,-0.0117179705,-0.018076152,-0.02558421,0.07295994,0.07247004,-4.237659e-08,-0.011502781,-0.09735289,0.004690558,0.011636287,-0.0023644848,0.063518934,-0.025166461,-0.01799753,0.076713674,-0.026643826,-0.0020015475,0.11064403,0.026875902,0.0009024335,0.07121095,0.03259285,-0.030728202,-0.024032172,0.016087312,0.027640872,-0.027627664,-0.010950099,-0.08649472,0.011423772,-0.004556614,-0.0708657,0.008783961,0.063519135,-0.0019732672,-0.03589096,-0.0173723,0.018372068,0.01933404,-0.011301021,-0.04246399,-0.0025428254,-0.022478502,-0.020253817,-0.0630141,0.1495727,0.030304337,-0.05914567,-0.048818715,-0.021752719,0.012093882,-0.03820865,0.0084000975,0.046793487,0.010214739,-0.042370852,-0.07987105,-0.013601965,-0.008235058,-0.045045998,-0.049018092,-0.02240002,0.016366245,-0.057703033,-0.03644709,-0.041390054,0.06727173,0.077804156,0.1890314,-0.009925743 +1.8.2.7,"The enzyme, characterized from the haloalkaliphilic sulfur-oxidizing bacterium Thioalkalivibrio paradoxus, contains three copper ions in its active site. It catalyses the direct conversion of thiocyanate into cyanate and elemental sulfur without involvement of molecular oxygen.",384,1.0,-0.08936145,-0.0047962824,-0.12062787,-0.014405137,-0.0031469504,0.012043675,-0.026249124,-0.0025928253,0.016580595,0.005381199,0.0086087845,-0.13909622,0.00890515,-0.024720829,-0.026796656,-0.020449145,-0.044640016,0.030374886,-0.03036828,-0.033806402,0.09453822,0.07196177,-0.03579909,-0.015459025,-0.0049044974,0.12727164,0.04838091,-0.041722152,-0.045706715,-0.057241768,-0.04236381,-0.01134817,0.0051485063,-0.015365867,0.071993515,0.053073183,-0.13608311,-0.014083105,0.030375011,-0.053803522,0.06469059,0.05704397,0.011925656,-0.006617115,-0.018260922,-0.044023134,0.10026886,0.008289874,0.011029154,-0.07818151,-0.008358288,-0.03939888,-0.06265074,0.11819531,-0.024278983,-0.0017006008,-0.039729103,-0.022157421,0.015417615,-0.049119662,0.0486316,0.02681189,0.03568019,0.033878624,0.059954163,-0.039067842,-0.038160153,-0.062666655,-0.013763195,-0.0891368,-0.04675169,-0.013645797,-0.04267157,0.019134177,0.005057548,0.07909432,0.10791138,-0.029560246,0.06911751,-0.032685433,0.031074062,-0.0018443378,0.06369661,0.11761665,0.044215623,0.02620691,0.00885641,-0.0017437902,0.011608031,-0.029440403,0.10039899,0.041178018,0.02950009,-0.08631798,-0.017464083,0.030980634,0.001645385,0.078419834,0.03842652,-0.002460682,0.09034127,0.07673687,-0.039490048,-0.1026739,-0.08725147,-0.0028877954,0.005522788,0.08682513,0.011273506,0.023600267,0.0037461775,-0.08111225,0.037547328,-0.0233052,0.005979014,0.12779571,0.0384858,-0.008281197,-0.09997344,0.0018902803,-0.059861794,-0.006478832,0.040104393,0.007026445,-0.02975978,-0.0028950241,-0.1502786,4.4400615e-33,0.045055322,0.02642414,0.052860323,-0.13607346,0.04747222,-0.038929958,-0.053529073,0.015821625,-0.016050698,-0.0118505005,-0.082711145,0.0062543163,-0.016096888,-0.038644046,-0.021220222,-0.011644578,-0.08017453,0.021397695,0.043063287,-0.009401664,-0.011273737,0.01036615,-0.028503086,0.000620584,0.021370431,0.08066217,0.054560136,0.0038390902,-0.037544,-0.002821372,0.0017679045,-0.08534729,-0.04539291,-0.013487374,0.052299116,0.001026084,-0.013091779,0.02910294,-0.025329193,0.02521116,-0.026381742,0.01563936,-0.025401834,0.006462025,0.013757246,-0.07036678,-0.09480124,0.09402245,0.033891037,0.01753195,-0.011137022,-0.055425774,0.12520047,-0.009927708,-0.029200686,0.015961058,0.006096141,0.01336058,0.058599573,-0.003196686,0.056136332,0.033533465,-0.07594818,0.06689973,-0.053806882,0.028553331,-0.06975353,0.012191589,0.019502157,0.07822338,-0.08106506,0.015203523,0.046127845,-0.022244055,0.028613904,-0.024244301,-0.057446636,-0.03975308,0.01832433,-0.0053317905,0.0005710851,-0.07985525,0.052375063,0.0041617127,-0.03344559,-0.052470207,-0.030585494,-0.0046494915,-0.06405049,0.03200942,0.0679817,-0.0432394,-0.06325802,-0.005895318,-0.006507811,-4.498447e-33,0.065167576,0.0015126108,-0.0027509814,-0.080842316,0.013147931,-0.014638726,-0.030527133,-0.04192047,-0.00012856444,-0.038435288,0.08320228,-0.00047343323,0.071532585,-0.04654193,0.047278013,0.025861854,0.06370214,0.09912566,-0.027646057,-0.021915484,0.020060617,0.016567616,-0.033980507,-0.090803154,0.0033340035,0.0032425495,0.017654842,0.04922074,0.075360194,0.06903424,-0.015438408,0.03331969,-0.013180071,-0.055568114,-0.12377463,0.01602116,0.027827535,0.0017585754,0.05535881,0.064449616,0.047287624,-0.025812628,0.035346944,0.122205436,0.010985588,0.06814864,-0.032829702,-0.017351776,0.006453031,-0.018120548,0.087427415,0.0110969,-0.0070678084,0.033280894,0.030188918,0.09531438,-0.010069176,0.021547996,-0.09082462,-0.03297461,-0.0746043,-0.0913031,0.040177513,-0.043045674,-0.008401734,0.04255859,-0.027902696,0.07158427,0.0068381377,-0.04861601,0.05331163,0.00026683445,-0.024628628,-0.02646751,-0.04058325,0.016697679,-8.291677e-05,0.02753727,0.0304241,0.0031891435,0.005485369,0.04504958,0.032062102,-0.08912713,0.0510923,-0.06658024,0.023432136,0.12824802,-0.041654896,0.055782214,-0.07914009,0.021346586,0.03768196,0.06401001,0.023594854,-3.3071505e-08,-0.06316257,-0.07086215,0.016267221,0.028933194,0.011744203,0.11594951,0.062372457,0.011027921,0.04647216,-0.05210589,0.0057153874,0.04294011,0.005102964,0.02544073,0.058053818,0.05392486,-0.035835266,0.0063599134,-0.0062841517,-0.07070725,-0.03205951,-0.03479289,-0.061148316,0.012630543,0.004948396,-0.031455014,-0.002396187,-0.041997876,-0.10362639,0.017321723,-0.033274535,0.03202148,-0.032209843,-0.044434275,-0.06225104,-0.011659748,-0.020319767,-0.063177474,-0.015433737,-0.042772822,-0.021739088,0.020749856,-0.12531397,0.044523623,0.044830084,0.015791137,-0.003967698,0.07222096,-0.03060866,-0.043457624,-0.017194666,-0.014850733,0.019737098,-0.07391455,-0.022177037,0.071605,0.07234579,-0.01996697,-0.07673652,0.04985892,0.089354046,-0.0068884627,0.14290388,-0.05212528 +1.11.2.6,"The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.",384,0.99999994,-0.063017465,-0.0051572337,-0.18203822,-0.049216896,0.10698964,0.07580396,-0.06897707,0.03597027,0.071943454,-0.020846093,0.0021746606,-0.006269994,0.032336663,0.0021682028,-0.046389237,0.0528717,-0.07924228,0.0047527426,0.04796824,-0.078940414,0.05588567,0.07205219,0.04722346,-0.0039206776,0.072446324,-0.03804589,0.009447739,-0.0029160597,-0.04973999,-0.06303761,0.029993473,-0.04189541,0.029555205,-0.067213334,0.0532327,0.05413443,-0.045014698,-0.03129162,0.1383997,0.033141688,-0.035465583,0.017548375,-0.039000425,0.026675649,-0.045862917,0.044390637,0.056461953,-0.0014555791,-0.0075367745,0.0046702344,-0.029824948,-0.034656465,-0.07153752,0.032533836,0.00906674,0.04242561,-0.046682082,-0.046066374,-0.038719885,-0.017858941,0.057084333,-0.026485097,0.02823718,0.047162045,-0.09358119,-0.037959434,-0.01826872,-0.09069863,0.0230544,-0.10843495,-0.052293435,-0.038724996,-0.010216836,0.0224282,-0.031952374,0.025917388,-0.01690175,-0.004834394,-0.007932629,-0.0074637127,0.0394366,0.015507346,0.025406012,0.13375774,0.029269647,-0.0069052,0.040504444,-0.0044907895,0.04467534,0.059053622,0.07382503,-0.04668287,0.00907416,-0.008179505,-0.06340031,-0.031881757,0.03131306,0.044574134,-0.009578162,-0.024162387,-0.05147953,0.02354843,-0.015278376,-0.0054700803,-0.020259215,0.010580945,-0.017641043,0.073004045,0.067214884,-0.025305653,0.0063268114,0.021007676,0.019912457,0.023234205,-0.035675477,0.021352023,0.123994134,-0.108251564,-0.047515113,-0.0044871303,0.032843187,0.01015351,0.005247611,0.0459603,0.015156318,0.022724656,-0.052026633,1.627194e-33,0.02329642,0.07157093,-0.028699031,-0.034066297,0.022517132,0.014028339,-0.092488386,-0.025300292,0.007124851,-0.015291298,-0.0940659,-0.08029261,0.012834695,0.036748108,-0.04497979,0.015616228,-0.011555505,0.015759222,-0.0074549797,-0.00056596583,-0.0062160846,0.055489592,-0.07440145,0.007932015,0.030778518,0.03757548,0.027330665,0.048008747,0.049215958,-0.017557079,0.0011482555,-0.042189613,-0.040697347,-0.010846443,0.046482485,-0.03614142,-0.04282202,-0.033894993,0.029230976,0.005833664,-0.0037252116,0.12039248,0.0008613457,-0.020549325,0.082946934,-0.12531824,-0.017137619,0.16951226,0.087752156,0.05168834,0.05156358,-0.0137680685,0.103762925,-0.02133228,-0.048051823,0.043566212,-0.011490466,0.03935447,0.030178992,0.09067916,0.027900947,-0.010459042,0.022604637,0.024724742,0.06832652,0.023015926,-0.047080114,-0.04842589,-0.02442956,0.03953042,-0.058616694,-0.0013161234,0.03757813,0.00867967,-0.05515763,0.0065402132,-0.092566125,-0.00656909,0.07369918,-0.041895665,-0.016997878,-0.027437214,0.0091056675,-0.061268732,-0.051440854,0.035664402,-0.06190359,-0.106317274,0.003576946,0.04845663,0.02094495,-0.08942044,-0.10605915,0.032205943,0.035964344,-3.013817e-33,0.062346593,-0.06768399,0.059682716,-0.111942604,-0.021707067,0.113592744,-0.009736805,-0.020813918,-0.0045015295,0.003218119,0.04800098,-0.0026413645,-0.038373582,-0.066133246,0.026557028,-0.07200095,0.042215906,0.11644122,-0.049665295,0.036923535,0.023318248,0.051920358,0.00899965,-0.050574716,0.03214546,0.019904546,-0.077480525,0.10273567,0.028091913,0.014654854,0.03588184,-0.025706986,-0.032515217,-0.0660065,0.0018076876,0.05053042,-0.05463471,0.049272787,0.08148927,-0.057244167,0.1005032,-0.019954026,0.0037245627,0.06469595,0.03655824,0.034435052,-0.15882318,-0.013110519,0.08149632,-0.054863807,-0.08021887,-0.006783202,0.04887944,-0.010371521,0.015415759,0.006601044,-0.022311194,-0.029795792,-0.024346838,-0.053895812,-0.007437854,-0.010384038,0.038612843,0.036226623,0.020459931,0.013150949,-0.081746526,0.08003484,0.10342339,-0.012252499,0.0411567,0.038064335,-0.036275964,0.002007886,-0.077114746,-0.025460696,-0.04079449,-0.09373192,0.02519428,0.037651464,-0.03536614,0.034857772,0.012995214,-0.050129954,-0.06714564,-0.0067725894,0.022064483,0.057251565,0.03367813,0.012082914,0.01648097,0.021944925,-0.032600258,-0.02295194,-0.003840257,-4.0791498e-08,0.05114422,-0.023781883,0.09355212,-0.012443451,-0.055254135,0.003191868,-0.04129918,-0.015347827,0.004598693,-0.014215474,0.0103451805,0.059289742,0.0022066566,-0.064236306,-0.017065171,0.029466145,-0.051921193,-0.013167595,0.008157074,-0.021764193,-0.060348388,-0.015589374,-0.04876299,0.057484634,0.042582814,-0.05927914,-0.009810319,0.01754426,0.022512283,0.044315465,-0.0063445303,-0.017798826,0.0015611378,-0.042144693,-0.07028397,-0.020620482,-0.041748248,-0.02456865,0.028762067,-0.044863425,0.079187915,-0.007829259,-0.07776117,0.034523837,-0.0030800556,0.025751377,-0.002285046,-0.07486549,-0.06221676,-0.02449419,0.0816007,-0.014173226,-0.039637186,0.013162529,-0.12889755,0.015221743,-0.028188145,-0.03213551,-0.013257011,-0.04380216,-0.03560841,0.0038028546,0.22337101,-0.0015777039 +1.13.11.90,Requires Fe2+. This bacterial enzyme is involved in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.,384,1.0,-0.045075852,-0.02780392,-0.020505099,0.0045545627,0.07965785,-0.031746294,-0.03865054,0.057225645,-0.02727877,-0.028193377,-0.0696024,-0.030447561,-0.019455127,0.07530712,-0.037439864,-0.011652073,-0.08830538,-0.0026028021,-0.0056092385,0.039162222,0.07261343,0.05057554,-0.0034182845,-0.04598385,-0.0035348805,0.06176581,0.060907263,-0.002381093,-0.0067180237,-0.00083220657,0.025293818,0.03387112,0.11331891,-0.15959506,0.019814352,0.11508906,0.0003298044,-0.06721052,0.031243257,-0.05793056,-0.024418863,0.042612404,0.011826486,-0.015476079,-0.051743068,-0.045746744,0.023608886,-0.00685657,0.05978062,0.026517484,-0.022691302,0.0061931433,-0.003694996,0.053630773,-0.011291182,0.047304187,-0.0108266,0.030610612,-0.063486,0.009343595,0.009861292,-0.055523444,-0.014223092,0.05663639,0.021416178,-0.0006461729,0.10499145,-0.07667352,-0.0076791486,0.03559394,-0.038769238,-0.013804929,0.008671765,0.01019941,0.0006978148,0.029623773,0.11766556,-0.078593425,0.039912853,0.0035155774,-0.031277824,-0.06672607,0.03520182,0.007163103,0.017632365,0.048251256,-0.06076669,-0.06282236,-0.02621991,0.07377733,0.0013333871,0.058163803,0.030804979,-0.060406506,0.010746606,0.07532957,-0.042314675,0.02491241,0.036731042,-0.0059203547,-0.08057729,0.08823857,-0.037770655,-0.063151345,0.002426653,-0.05010826,-0.04828027,0.044307314,-0.054802787,0.025784144,0.05729686,0.020401549,0.066595204,0.0044960007,0.026502639,0.0653622,0.0182019,-0.075666025,-0.09527289,0.032701913,0.04845623,-0.051363073,-0.06548724,0.0043439097,-0.10517987,0.0036659322,-0.06658412,-8.940873e-36,0.035147246,0.040140994,0.029035341,-0.08650512,0.02514196,-0.010752775,-0.10043634,-0.0050919983,-0.034967665,-0.1096622,0.005374498,-0.08824555,0.03905589,-0.06121386,0.011618076,-0.01402799,0.052930757,0.079841055,0.05278984,-0.022734346,0.085251205,0.04630519,0.05608144,-0.010466862,0.07465065,0.06499929,0.025129126,-0.019714352,0.026457,-0.016405717,0.01604456,-0.10690938,-0.09231337,-0.05597167,0.063240334,-0.020238576,-0.055970043,-0.012744209,-0.028356997,-0.004343659,-0.009354541,0.08563642,-0.02776651,0.024764579,0.038114913,-0.110009395,-0.072114296,0.11652149,0.0057146554,0.13145883,-0.0012070038,-0.025547842,0.03127919,0.028421408,-0.058473773,-0.03086876,0.032204915,-0.09466319,0.004609929,0.003038375,0.029732546,0.025714057,0.019586379,0.041487165,0.06346771,-0.03729407,-0.041957878,0.0025947257,0.027874267,0.06877645,-0.054895807,-0.032599106,0.02061309,0.06419403,0.018794354,-0.07324531,-0.033161942,-0.039868705,0.11232876,0.031278864,0.022917373,0.0027997596,0.0073723462,-0.011288806,-0.016237887,-0.060774438,-0.04349123,-0.005012572,0.010423325,0.013454226,0.035358068,-0.08827597,-0.07853929,0.04147513,-0.040190008,-2.5365243e-33,0.061023645,-0.022047097,0.05412951,-0.05727819,-0.0687467,0.066173375,-0.01653613,-0.021673715,0.023382902,-0.014779546,0.05936674,0.009401495,0.028341789,-0.02125095,-0.04898342,0.0336437,0.013951133,0.058855366,0.011148606,-0.009817056,0.06510962,0.098783635,0.008485377,0.0752225,0.028065091,-0.032437522,-0.076373436,0.023990508,0.010124135,0.119355224,-0.02435092,0.00038494813,-0.07210963,-0.090390116,-0.01388674,0.055876657,0.014676378,-0.003654265,0.067176536,-0.0078022834,0.05865413,0.05367091,0.06345185,0.022906315,-0.045702975,0.013903838,-0.05864229,0.07672647,-0.06293777,-0.01219837,0.007347853,-0.013146634,-0.056893695,0.040404353,0.004329667,-0.027448008,0.041332614,0.063312635,-0.08598828,-0.014593434,-0.017393287,-0.0887966,0.016848808,-0.025549663,0.031544555,0.023877643,0.032547448,0.10164316,-0.010454566,-0.032276206,0.050635625,0.08735739,0.07843656,0.031991232,-0.037402734,-0.023187345,-0.10549534,-0.06409558,0.013516893,0.015636586,0.024218226,0.04066503,-0.01290233,-0.031755723,0.023452567,-0.09905652,0.037220504,0.008296186,-0.06724291,-0.029116811,-0.04351399,-0.03319332,-0.04880969,0.030284539,0.026753962,-2.837554e-08,-0.03294844,-0.024257604,0.027670532,-0.10831872,-0.008004105,-0.017201383,0.0010119864,-0.044472065,0.04684032,-0.06967691,0.0075380234,0.047373954,0.039564118,-0.0024184634,0.028473519,-0.01836535,-0.045485333,0.062021792,-0.04425788,-0.062064152,-0.083108574,-0.05607207,-0.079369195,0.033169612,0.041934047,-0.020627806,0.031470854,0.014101842,-0.00602188,-0.021058023,0.0070745987,0.029736262,-0.054194983,-0.019173848,-0.105518326,0.006378904,0.007903932,-0.04438268,-0.079781786,0.05681168,-0.05127309,0.060095776,-0.07535911,0.022467753,0.019428965,0.01544349,0.032621708,0.0660187,-0.03796808,-0.04555897,0.09973862,-0.046633992,0.027035182,-0.094147645,-0.10810563,0.039436158,0.02309138,-0.0011954702,0.042255037,-0.02209522,0.056629315,-0.02083658,0.18199213,-0.04983046 +1.14.11.72,"Requires Fe2+ and ascorbate. The enzyme, found in bacteria, participates in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.",384,1.0,-0.049518183,-0.038331043,-0.050187938,0.0496926,0.07134663,0.0028140086,-0.024442548,0.05149893,-0.013104351,-0.018493813,-0.037064735,-0.012974244,-0.036695633,0.06777607,-0.036596306,0.01153221,-0.06088819,-0.010453575,-0.020954255,0.018053707,0.11024693,0.06412725,0.019498862,-0.047597233,0.005226,0.020077765,0.030460691,-0.04173757,0.0065354137,-0.0314865,0.019919077,0.0052407435,0.10892,-0.12920466,0.019674782,0.12240545,-0.00052802294,-0.06690928,0.040041883,-0.014877668,-0.004205595,0.027470358,-0.0155620035,-0.005627905,-0.043381024,-0.054399606,0.033948638,-0.013887656,0.04631406,0.0393821,-0.03557329,0.0011711434,0.0019514814,0.043706823,-0.058817957,0.06689261,0.00016225391,0.011415564,-0.092483,0.021533148,0.00776758,-0.041949183,-0.017292723,0.048401307,0.020358613,-0.011665335,0.07416633,-0.049911264,-0.0069084503,0.017221656,-0.032293525,-0.03869583,0.022775704,0.04059743,0.006782353,0.034909528,0.088771336,-0.06757777,0.029503522,-0.024996756,-0.004775828,-0.07659899,0.03522419,0.013959243,0.017964313,0.055286083,-0.050603684,-0.037405893,-0.021322798,0.09069712,0.0010093601,0.04194614,-0.012296425,-0.06675987,-0.013585415,0.050747775,0.022826072,0.028484212,0.051906265,-0.01743009,-0.06255357,0.09230019,-0.046653915,-0.04641062,0.0023761587,-0.038883515,-0.08342989,0.012708083,0.01012916,0.016461648,0.03632503,0.032562908,0.038221452,0.0006595444,0.050272293,0.07554953,0.029138848,-0.09086977,-0.0981674,0.02489669,0.032851476,-0.05850976,-0.055798944,0.04726944,-0.08495889,0.021942569,-0.062743805,-8.804907e-34,0.044529133,0.04950722,0.017499132,-0.07229173,-0.016284114,0.0044033863,-0.080535956,0.009849078,-0.026903411,-0.11815923,-0.0064020874,-0.09449491,0.06538841,-0.045643162,0.018918416,-0.03268003,0.05726279,0.040634222,0.065600544,-0.033384383,0.08532291,0.047282897,0.021573959,0.022493444,0.012327649,0.057234935,0.015169552,0.0071676616,0.029298868,-0.021546276,0.02283263,-0.11540739,-0.096064925,-0.04208717,0.097156085,-0.0139504885,-0.06113969,-0.00847185,-0.052313954,-0.026902676,-0.025520472,0.08486633,-0.04564356,-0.0021606653,0.031475015,-0.1127988,-0.06675373,0.09818866,0.035854734,0.120591395,0.014430184,0.0010070014,0.090080634,0.0524314,-0.032392353,-0.0074716406,0.0029486585,-0.11118254,0.01382953,0.0009936554,0.050419595,-0.0015492085,-0.013623162,0.05241807,0.026063124,0.01204877,-0.039718874,0.007267624,0.030281447,0.08139636,-0.0710052,-0.030111112,-0.028544007,0.054112658,0.0085561145,-0.04443979,-0.058786076,-0.02893237,0.08106014,0.009806742,0.020677326,-0.015313326,-0.012374706,0.00089482975,-0.027045028,-0.048898093,0.002164787,-0.019948017,0.024333796,-0.0016122014,0.04728963,-0.074118346,-0.07106394,0.00808538,0.0073869782,-2.4026157e-33,0.09212701,-0.044236366,0.05348173,-0.031722892,-0.06533533,0.08472196,0.013132234,-0.027420329,-0.0006651752,-0.031172208,0.040925115,0.012223362,0.03497831,-0.035177957,-0.015795296,0.02267858,0.004702793,0.09768165,0.036607336,-0.0057551875,0.05024616,0.120684095,0.012646184,0.09660231,0.023950838,-0.04470245,-0.10201113,0.0015320027,0.010638923,0.097010456,0.016158385,0.006115874,-0.0649567,-0.104893096,-0.017640496,0.05846,-0.028675016,0.00870062,0.026080657,-0.010618883,0.047510948,0.052348137,0.063977174,0.07047166,-0.030393187,0.02881886,-0.107751936,0.09440355,-0.04612751,0.00038501533,0.020682868,-0.027689107,-0.059245702,0.008053105,0.023910899,-0.012544165,0.030587371,0.035991173,-0.07872785,0.0074822586,-0.027113736,-0.094630726,-0.014127037,-0.03187937,0.033379,-0.009017742,0.048421778,0.10814682,0.020045385,-0.016790343,0.052329417,0.10247833,0.054554373,0.021975901,-0.057866585,-0.008906322,-0.10481916,-0.047786072,0.0007905435,0.0023625009,-0.014224567,0.055204224,-0.002463504,-0.03942565,-0.026668819,-0.11695682,0.039429754,0.008551864,-0.06927286,-0.026550658,-0.06693942,-0.055831663,-0.045214456,0.030262666,0.050163776,-3.3222374e-08,-0.03402396,0.0072826277,0.064094074,-0.105279684,-0.0027940006,-0.018875984,0.022505345,-0.042639285,0.051415026,-0.07393386,0.0039289244,0.061865926,0.05024914,0.0057141823,0.026286226,-0.029182043,-0.028512,0.06947672,-0.047281433,-0.04485918,-0.085634686,-0.051491413,-0.12303256,0.047863845,0.040927667,-0.015336894,0.033785723,0.037243422,0.022307679,-0.033136368,0.03555107,0.013052671,-0.008635401,-0.037185904,-0.1305993,0.005281369,-0.014119835,-0.053338032,-0.07067932,0.057961058,-0.051163547,0.036886342,-0.052670054,0.0272488,-0.009055129,0.017604873,0.039556716,0.041191973,-0.045394834,-0.02071957,0.054556653,-0.0431559,-0.009605648,-0.08371918,-0.106829576,0.03804039,0.0194598,-0.025383087,0.029591853,-0.05862041,0.05890939,-0.02301351,0.19500235,-0.058439523 +1.14.14.172,"The enzyme, characterized from a number of bacterial species, participates in the degradation of 3,5,6-trichloropyridin-2-ol (TCP), a metabolite of the common organophosphorus insecticide chlorpyrifos. The enzyme is a multifunctional flavin-dependent monooxygenase that displaces three chlorine atoms by attacking three different positions in the substrate. Each reaction catalysed by the enzyme displaces a single chlorine and results in formation of a dione, which must be reduced by FADH2 before the monooxygenase could catalyse the next step. The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpX). cf. EC 1.14.14.173, 2,4,6-trichlorophenol monooxygenase.",384,1.0,-0.076623015,-0.005568017,-0.10311233,-0.02356768,0.116607435,0.030618032,0.010181976,0.06816343,0.04788494,-0.042714845,-0.016795462,-0.06435566,-0.045292605,0.058178857,-0.070191495,0.035048947,-0.08901045,-0.022833237,-0.04230658,-0.056946207,0.02698871,-0.004300313,-0.017311973,-0.025890367,-0.059479788,0.037560243,0.009785783,-0.06265798,-0.035796948,-0.053323362,0.04997409,0.06632148,0.062251154,-0.05399402,0.024796374,0.098694675,-0.031910207,-0.041400496,0.08202197,0.013535049,-0.030390715,0.06398941,-0.016892068,-0.041755714,-0.0017849591,0.02764807,0.043960918,0.058227785,0.013412665,-0.0018058757,0.004615285,0.0123960655,-0.06434265,0.04111213,0.053204417,-0.049096707,-0.056070056,-0.05114579,-0.06612305,-0.01105346,-0.0117352605,0.0045753713,-0.0075867753,0.0413559,0.024712307,-0.027306378,0.0130058555,-0.079671696,0.075413465,-0.023024758,-0.06543314,-0.007590057,-0.056010082,-0.0076766475,-0.0073125996,0.029780427,0.04983399,-0.030178096,0.027406974,-0.04747424,0.011762714,-0.037052568,0.06342238,0.07920142,0.057954006,-0.06831533,-0.03666832,-0.011521393,0.017363371,0.065123,0.08696088,0.05038622,0.052005343,-0.061348636,-0.05419856,0.10826382,-0.024936209,-0.046166304,-0.026333949,0.015885828,-0.055714935,-0.007711805,-0.0033900514,-0.030620752,-0.059621908,-0.047955662,0.0081096,0.098761275,0.027277436,-0.035050035,0.00411273,0.0151431095,0.098971084,-0.02837301,-0.035942517,0.103401534,-0.03133158,-0.093725465,-0.051874764,0.060498457,0.003083452,-0.039457276,-0.023746705,0.08057309,-0.010561299,0.04718466,-0.08179842,5.050103e-33,0.019135993,0.03381724,-0.012256374,-0.016446352,0.0155176325,-0.059464797,-0.01833454,0.0056364248,-0.04133852,-0.0669215,0.038468637,-0.06766431,0.017918538,-0.017664392,0.035083663,-0.0442873,-0.024907498,0.021653002,0.06974398,-0.019112036,0.007174097,0.027216965,-0.028298477,0.012653339,0.06390029,0.08005146,-0.038971137,0.049952168,-0.014212968,0.02462157,0.08509139,-0.03439016,-0.07805892,0.0634732,-0.008594239,-0.005169326,-0.10789956,-0.04979863,-0.047317483,0.080122165,-0.027588656,0.028878327,-0.043664716,0.023659166,0.08311127,-0.14197391,-0.105385505,0.13360628,0.050494518,0.0987426,0.02117769,0.021027876,0.09920825,0.041015442,-0.036004163,0.08465285,-0.018518155,-0.07963443,0.02841708,0.004107387,0.071791254,0.029377332,-0.1271935,0.034121256,0.057930656,0.004888123,0.026773395,-0.0757588,0.02065421,0.0725913,-0.014981603,-0.013130658,0.031671528,0.045939546,0.048181344,-0.020280518,0.025695011,-0.009290643,0.01240549,0.021118011,0.016695805,0.031487986,0.10458504,-0.08234468,-0.023921661,-0.016079843,0.0069887275,-0.085480094,0.0046291705,0.008692035,0.06925662,-0.11881541,-0.07040178,-0.028150532,-0.024736108,-3.5279252e-33,0.027892899,-0.04377442,-0.040621616,-0.07362663,-0.038314436,0.019008808,-0.014254917,-0.051562574,0.0017042508,0.0056120176,0.047107484,-1.4687021e-05,0.009116482,0.0015293525,0.052175276,0.010166176,0.045050703,0.04662821,0.0018859322,-0.009315792,0.0069894497,0.04111337,0.03773449,0.034933764,-0.021018561,-0.0037900463,-0.046745613,0.05116595,0.09058005,0.044509232,-0.07087361,0.031438936,-0.024398966,0.016455764,0.013720088,0.002730306,-0.02042046,0.02747142,0.006956226,0.0854942,0.06553621,-0.012100335,-0.0069154743,-0.03700048,0.0033035846,0.058983453,-0.12003527,0.0046196114,0.022811972,-0.11367347,-0.01158591,0.061084773,-0.055664193,0.008941831,0.03988107,0.027904987,0.036737036,0.0022623301,0.029159792,-0.06818109,0.012794296,-0.05934249,0.043456364,0.06697369,0.073463246,0.10513471,-0.0014579316,0.11369854,-0.023683647,0.017881988,0.013261745,0.010963156,0.06580705,-0.002721659,-0.045258112,-0.03147792,-0.049522612,0.044397373,0.03525045,0.010152577,0.050140552,0.032291606,0.015323353,-0.06904413,-0.046278138,-0.10661127,0.0008656431,0.0928766,0.010694797,0.012606985,-0.034073535,-0.027085064,0.0257874,0.00832642,0.08983883,-4.343605e-08,-0.015559765,-0.072863504,0.032845795,-0.022480609,0.0069399225,0.045922894,0.024430674,-0.024345754,0.0052831005,-0.074436374,-0.026091637,0.074772604,0.068381615,-0.028299816,0.038152225,0.015003654,-0.08745325,-0.04634938,-0.017182086,-0.053019565,-0.0664911,0.046201285,-0.051968478,0.022520607,0.011719582,-0.016119268,0.011530353,-0.021358855,0.00076226494,0.026446713,-0.037261292,0.029019557,0.002167566,-0.019500285,-0.0998256,-0.029689616,-0.05913815,-0.055426005,-0.055332433,0.092976145,-0.03185115,0.03165545,-0.078160934,0.019699855,0.12841539,0.012879795,0.06332591,0.014271413,-0.023706852,-0.059971947,0.058232684,0.006014684,-0.016281854,-0.034590144,-0.11572468,-0.017094193,-0.00943523,-0.072082125,-0.037630808,-0.041395646,-0.003757242,0.062367693,0.17789452,-0.0012577518 +1.14.14.173,"The enzyme, characterized from Cupriavidus pinatubonensis, participates in the degradation of 2,4,6-trichlorophenol, a compound that has been used for decades as a wood preservative. The enzyme is a multifunctional flavin-dependent monooxygenase that catalyses two different reactions to displace two chlorine atoms, a monooxygenase reaction followed by a hydrolysis reaction that takes advantage of the reactivity of the product of the first reaction, 2,6-dichloro-1,4-benzoquinone [2]. The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpB). cf. EC 1.14.14.172, 3,5,6-trichloropyridin-2-ol monooxygenase.",384,1.0,-0.08038857,-0.03542778,-0.10830822,-0.020927023,0.13516307,0.0103462245,-0.031119633,0.0770066,0.05634548,-0.056403786,-0.016915085,-0.06654268,-0.10787726,0.044348706,-0.1108834,0.010716445,-0.0801839,-0.025380382,-0.032157473,-0.030619115,-0.0005424457,-0.041343443,-0.0041685198,0.033075456,-0.0122154765,-0.048712153,0.018190268,-0.051069114,-0.059216622,-0.03605589,0.09026126,0.0247947,0.033956904,-0.016845338,-0.051594075,0.11030113,-0.008130119,-0.088798836,0.051265538,0.016632387,-0.04702552,0.015791463,0.03758972,-0.024882024,0.04508104,0.028323216,0.006967293,0.06547091,0.004949851,0.04177491,0.006870956,0.00031395507,-0.06356973,-0.0056868424,0.049735863,-0.0058009857,-0.060068,-0.03976339,-0.03983101,0.053109553,0.02756848,0.03156494,-0.04319082,0.045908973,0.0014776818,-0.00029008565,-0.057293594,-0.035073146,0.06312732,-0.02102077,-0.042915598,-0.011384877,-0.030950636,-0.03260663,-0.014054557,0.0075361985,-0.012312686,0.023954052,0.08116243,-0.04610024,0.01829843,-0.009633403,0.056452565,0.0951877,0.03186244,-0.030663151,-0.0144567,0.005558936,0.0077525973,0.035273522,0.09837849,0.08035701,0.024355248,-0.002235467,-0.07799027,0.1180079,0.007215223,0.0070411423,-0.022494916,-0.005054109,-0.043398324,0.013019398,0.011810368,-0.090282746,-0.0794011,-0.062973745,-0.014780475,0.103157505,0.07081535,-0.04073757,0.013030424,-0.0005905431,0.06774634,-0.00980069,-0.014798053,0.1250349,-0.012568723,-0.14683315,-0.082346305,0.04522605,-0.028830271,0.012919934,0.033568054,0.042324223,-0.012085001,0.033258606,-0.027940124,3.8812245e-33,0.046132106,-0.041348487,-0.015254744,0.009154972,0.03264681,-0.01184483,-0.047966983,0.003955218,-0.0703161,-0.02841535,-0.01499263,-0.05878093,-0.017129289,-0.05369863,0.047363736,-0.052887134,-0.019105583,-0.035722066,0.039288927,0.001467244,0.003140085,0.06318926,-0.046749346,0.059666745,0.06313572,0.09178523,-0.03782082,0.014139834,-0.0060438802,0.036598086,0.04426919,-0.04868457,-0.103407934,0.025351288,-0.06833075,-0.017597146,-0.13335532,-0.038010154,-0.039038192,0.056580156,-0.00057942176,0.049042195,-0.028857421,-0.002570761,0.0853857,-0.111268155,-0.06904957,0.1509133,0.028149126,0.07136357,0.020237384,0.060286302,0.084868684,0.06619631,-0.055989973,0.037297554,-0.011892463,-0.0037275346,0.056678433,0.0150784375,0.05299718,0.07588562,-0.08837363,0.0280625,-0.004759038,0.015804581,0.017287325,-0.033017747,-0.01354617,0.056687713,0.003139153,-0.08674737,0.0055766883,-0.011377859,0.050382566,-0.02956359,0.03685974,0.01723066,-0.016165275,-0.013554641,-0.020148221,0.03646882,0.07308476,-0.01680669,-0.059009716,-0.0046889745,-4.1420488e-05,-0.057007436,-0.010165899,0.052567776,0.07643652,-0.050391417,-0.06338494,-0.051640097,0.0026786877,-3.109498e-33,0.05923914,-0.08890749,-0.018604439,-0.06558594,-0.004822786,0.037420876,-0.02945389,-0.05990374,0.05955387,-0.03742395,0.040767837,0.01926411,-0.010982575,-0.0011442684,0.07034983,0.047964863,0.007709389,0.11336471,-0.0149975205,-0.01713738,0.04421119,0.09623147,0.014898114,0.0328703,0.0077410857,0.004750884,-0.03285568,0.024628587,0.07647962,0.060059503,-0.06706417,0.0153147,-0.03150914,0.002600047,-0.021450548,-0.0184803,0.0049187886,0.017794782,-0.038126033,0.073298134,0.04788416,-0.00017798235,0.0024552005,0.010317604,0.03281639,0.0675241,-0.16529562,-0.011854237,-0.016625037,-0.024755286,-0.011190064,0.021909494,-0.027540257,0.022701249,0.010770146,0.031657785,0.025310911,-0.0036408538,0.015715536,-0.04322765,-0.013627753,-0.07485276,-0.0043088407,0.021649864,0.07081742,0.0673954,-0.016984778,0.14524451,0.010122059,-0.024271488,0.08269066,0.028277539,0.05381755,0.05167555,-0.04168878,-0.017814728,-0.042190846,0.029061057,0.017656509,0.019834023,-0.015726632,0.056093328,0.08301774,-0.05741172,-0.010698509,-0.1325379,0.028804291,0.07008298,-0.00860521,0.020056074,0.0045635113,-0.039974153,-0.02980512,-0.021640338,0.105054796,-4.7299785e-08,-0.05546554,-0.07622152,0.021436311,-0.037815943,0.011298625,0.03639182,0.039359257,0.044945586,-0.029977351,-0.095814794,0.00172293,0.1100333,0.035679873,-0.006166503,0.015187427,-0.0027595407,-0.030944701,-0.047566038,-0.040381256,0.017074063,-0.048140164,-0.002628166,-0.030804925,0.028776107,-0.042517744,-0.039842945,0.008844798,0.0019497905,0.004395664,8.427161e-06,-0.0017897281,0.059303198,0.05122069,-0.009997959,-0.09582437,0.014117525,-0.03633788,-0.038066186,-0.08123539,0.058902223,-0.08591167,-0.037765633,-0.031701263,0.01798744,0.056153603,-0.044338852,0.065884575,0.020420454,0.02968302,-0.02343648,0.052227244,0.023382833,0.0032858206,-0.034751173,-0.08048059,-0.04068834,-0.007955326,-0.041582413,-0.007392969,-0.1006834,0.04782956,0.042151358,0.19694601,-0.0029448704 +1.14.19.77,"The enzyme catalyses the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine. The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria.",384,1.0,-0.036481768,-0.046333686,-0.091283455,-0.016391322,0.027502956,0.06871508,-0.048141375,-0.014202192,0.034956504,0.007957885,0.03717118,-0.08585316,-0.056206305,-0.0018905047,-0.04598574,0.044032417,-0.09129341,-0.028089821,0.04645854,0.028055575,0.15073805,-0.0036721632,0.039536223,0.00653276,0.057338648,0.06315034,-0.0075323954,-0.009399191,0.046144567,-0.046484474,0.07244714,-0.011266258,0.030845148,0.001737285,0.045775466,0.075862154,-0.030024188,-0.038714934,0.046522077,0.053738832,0.006850035,-0.033809647,-0.040614743,-0.11607933,-0.026948325,-0.05331927,0.0721555,0.005782719,-0.019803086,-0.0101961205,0.08238189,-0.08541627,-0.017960375,0.0062654265,0.023744192,-0.008902563,-0.057305425,0.06764176,-0.05008854,0.014319252,0.079251796,0.08036067,-0.009697159,0.057677697,0.060467776,-0.08621943,0.009036839,-0.052651674,-0.0013065913,-0.034239773,-0.04544788,-0.0943523,-0.004098513,0.01534292,0.01744813,-0.05244807,0.021631712,-0.026106289,0.033252854,-0.00517483,-0.015936732,0.01982046,0.01745785,0.09301009,0.05119383,0.07300684,0.012939696,0.007906644,0.0534716,-0.008189026,-0.0006755789,-0.03578891,-0.0050150366,-0.044030666,0.007449224,0.038280837,0.037773088,0.049200255,0.06168836,0.038851682,0.059559975,0.043158956,-0.056673013,-0.1061668,-0.012579518,0.03210234,0.001907512,0.036279306,0.030999789,-0.010668068,-0.011480818,0.028634017,0.04927356,0.047490526,-0.03967185,0.06928413,0.0037059907,-0.0637453,-0.022411114,-0.055765994,-0.01903838,-0.08409634,0.015633404,0.13036695,-0.027480742,0.04376647,-0.09890274,1.3131527e-33,0.019640937,0.008834655,0.006574467,-0.082332775,0.030014908,-0.010547892,-0.015418253,0.06778477,-0.06827107,-0.008312092,-0.08584616,0.022281062,0.0748623,0.056556847,-0.02908961,-0.06688783,-0.01870058,-0.0066239107,0.072665356,-0.0041838326,-0.03487144,0.009708121,-0.016647715,0.00923104,0.028563,0.052507445,0.012959333,-0.012434447,0.027301293,0.015730457,-0.099870816,-0.038863555,-0.09227302,-0.006684641,-0.040449392,0.031073373,-0.05039333,-0.026007732,-0.0056516686,0.07117195,0.015413716,0.034967996,-0.0028651592,-0.057338573,0.056992978,0.007802913,-0.089934886,0.10457727,0.039382674,-0.010581939,0.00056022743,-0.015391464,0.081966065,-0.015956229,-0.090155624,0.04783023,-0.03603285,-0.042200442,-0.06798271,0.028515229,0.0046238783,0.046422265,-0.0028401513,-0.040072992,-0.022127429,0.012636695,0.02762751,-0.014514383,0.04217582,0.0116065685,-0.09144863,0.036513805,0.0077226725,-0.033417087,0.04712859,-0.035456818,-0.01939447,0.015590998,0.041773647,-0.0069640614,0.009721437,-0.034689102,0.02112238,-0.07792476,-0.05806215,-0.047744382,-0.033804286,-0.060458787,-0.058054816,0.02775257,0.003346766,-0.114712745,-0.0121678235,0.051208816,0.023137351,-3.5772064e-33,0.069950715,-0.13616501,0.04987879,-0.1011993,-0.022334833,0.038414743,-0.0012414821,-0.05271048,-0.04542217,0.021176059,0.021233985,-0.0015857681,0.04660377,-0.0360857,0.010754006,0.0037802975,-0.021717753,0.08492531,0.04254259,-0.0472007,0.010857275,0.08058763,0.013303841,0.044378348,0.045363918,-0.008556068,0.008381732,0.04828827,0.035121225,0.037806615,-0.02840267,-0.09858238,-0.023505744,-0.042243972,-0.024225015,0.04981637,-0.007824347,0.018918931,0.019343818,0.0020653212,-0.002887317,0.02786855,0.015148733,0.060824484,0.057445623,0.12006469,-0.1226313,-0.0016099442,-0.020519283,-0.09425816,0.051703718,0.022144856,-0.011328511,0.003846477,0.024897134,0.089846686,-0.004149353,-0.018311068,-0.041592952,-0.027101597,-0.05203618,-0.015501149,0.004136563,0.05061798,-0.013728299,0.00094294915,-0.07490326,0.03619206,-0.002671853,-0.03552198,0.12156961,0.012485822,-0.021721803,0.09325433,-0.05608525,0.018137548,-0.0073029934,-0.1285227,-0.0027190554,-0.11034914,0.005020769,-0.019343061,0.023264853,-0.08301567,-0.05131378,-0.052476257,0.1255703,0.09775228,-0.04202899,0.027660819,-0.0005281558,0.026433876,-0.05835789,0.05552414,0.087670736,-4.151331e-08,-0.01925359,-0.06584896,0.04954885,-0.03789894,-0.00027274163,0.090966545,0.058405947,-0.005352149,0.04835386,-0.11718177,-0.05145306,0.06905316,0.033296525,0.022095678,0.07008921,0.021158349,-0.049690977,0.0072324877,-0.05329457,-0.028218634,0.0058067525,-0.0017699645,-0.06785266,0.010339046,-0.0010389792,-0.06668509,-0.04079184,0.11551406,-0.028627502,0.0084544225,-0.058644492,0.041155417,-0.028130446,-0.018979233,-0.029663593,0.07187668,-0.03796495,-0.0683417,-0.017716544,-0.04646246,0.008270346,-0.08931874,0.02062012,-0.030354274,0.054431442,0.011822477,0.035503205,0.0306921,0.022601502,0.0045482055,0.08133353,-0.022036294,-0.007953943,-0.09127302,-0.106995344,-0.049059805,-0.10075975,-0.04452696,0.014908596,-0.06423928,0.03372389,0.022696262,0.18022536,-0.012001751 +2.1.1.364,"This entry describes enzymes that catalyse a single methylation of the L-lysine4 residue of histone H3 (H3K4), generating a monomethylated form. This modifications influence the binding of chromatin-associated proteins and result in gene activation or suppression. Some enzymes that catalyse this reaction continue to generate a dimethyated form, these enzymes are classified under EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase. Other enzymes continue to catalyse a third methylation, those are classified under EC 2.1.1.354, [histone H3]-lysine4 N-trimethyltransferase.",384,1.0,0.03201621,0.023605624,-0.094818324,-0.063701436,0.02689238,0.067636676,-0.08594387,-0.019880343,-0.037154328,-0.06183397,0.0051305797,-0.040638287,-0.030549146,-0.024883231,0.031178534,0.07996374,-0.15804602,-0.010391897,-0.08119176,-0.10082204,0.047685146,0.056607597,-0.026883865,-0.028586978,0.0033345881,-0.05028512,0.033127982,-0.019549126,0.05720724,-0.039642688,0.026710968,-0.056859888,0.06491071,-0.06733142,0.09227218,0.045479514,-0.009806911,-0.04310113,0.06540504,0.026607977,0.052752346,-0.008607323,-0.063915305,-0.0009247026,-0.052213177,0.01017043,0.028160928,-0.04606964,-0.024333922,-0.043636173,0.008339866,-0.021005435,0.001939539,-0.029472243,-0.07332149,-0.045820024,-0.0547424,-0.01419156,0.04995697,0.016818617,0.026955955,-0.023147462,0.010462232,-0.03706443,0.0764506,-0.04710857,0.06976452,-0.09492771,0.03223025,-0.04110474,-0.055598874,-0.070821024,-0.032161035,0.07014353,0.03775589,-0.051471848,0.024496552,0.034417864,0.006356903,-0.02946956,-0.03786336,0.000936397,0.0244989,0.024364602,0.008877101,-0.009595488,-0.079822086,0.05728556,0.060975518,0.05031994,-0.016151618,-0.06967687,-0.008548187,0.011181526,-0.026462983,0.10735955,0.04649539,0.023131728,0.043259606,-0.0032002137,0.045171037,0.036541957,-0.14272667,0.046539765,0.052282467,0.07749207,0.030323775,0.09750304,-0.032609396,-0.026904155,0.02675661,0.0029233384,0.034477487,0.017552167,-0.040427648,0.09079537,0.0046410235,-0.02993967,0.025546875,-0.001970364,0.047887705,0.044364944,0.1004677,0.02630732,-0.02547565,0.01777415,-0.139582,2.937087e-33,0.050311,0.10627752,0.0072439504,-0.03268035,-0.01811037,-0.03446506,-0.07867661,0.03993924,0.021558743,-0.06425765,-0.0010468232,-0.0497629,0.07932955,0.013157882,-0.09530973,-0.043474216,0.018997561,0.019696778,0.0005200295,-0.019181121,-0.07067735,0.005328595,-0.013849777,0.06403249,-0.00027686864,-9.36631e-06,0.038909294,-0.0031185655,0.088035636,0.021395227,-0.0789507,-0.0991517,0.058415484,-0.0017674363,0.04547795,0.05504072,-0.021455262,0.02069723,0.04992204,0.09157436,0.021920335,0.025396606,-0.029435107,-0.07234088,-0.013185584,-0.018045636,-0.043581292,0.065167315,-0.04937814,0.024988666,0.015456945,-0.039116915,0.11151667,-0.08160725,-0.043493915,-0.010501446,-0.01676486,-0.056267336,0.021858586,0.021493237,-0.0413595,0.01826497,-0.0016044799,0.07490603,0.032931343,-0.07611687,-0.033426464,-0.025711121,-0.04826426,-0.011674648,-0.043880656,-0.006723565,0.13394481,-0.014571183,0.06551911,-0.07944514,-0.10661693,-0.034877054,-0.004420285,0.06774912,0.010219983,0.07489551,-0.028012415,-0.083747484,-0.022441125,-0.058288254,0.019919833,-0.09780173,0.01688718,0.024600964,-0.04711884,-0.065106094,0.015092568,0.0081724245,0.015687317,-4.6692384e-33,0.026723567,0.020898333,0.014652698,-0.043876484,-0.010061517,0.017932288,0.07176263,0.031667273,-0.017010123,-0.024149828,0.09330269,-0.01671696,0.006817187,-0.09659012,0.01773026,0.048469573,0.011226502,0.076704465,-0.0088038985,0.031100947,0.02066149,0.024744444,-0.07428111,0.13865936,0.020070061,0.009566605,-0.062130284,0.067391396,0.082690306,0.050568618,-0.060751706,-0.0453588,0.0054550567,-0.019245617,0.028492494,0.041711725,-0.024885466,0.016089054,-0.005132284,-0.0040690806,-0.011901859,-0.0009089617,0.011616729,0.07952849,0.008045467,0.10254936,-0.044515405,0.10098731,-0.016775455,-0.06961973,0.011804786,0.017873572,-0.029916096,0.06949415,0.030865233,0.04095046,0.045792297,0.043753367,-0.04830948,0.032200567,-0.06457067,-0.054251302,0.042507824,0.06524966,0.013229209,-0.005719648,-0.08268648,0.022702424,0.015119002,0.042711537,0.052971937,0.012455331,0.030688144,-0.028424334,-0.055480357,-0.00942805,-0.06727044,-0.111130975,-0.1092319,-0.06215753,0.02627848,-0.04755566,0.04769429,-0.06184752,-0.028052665,-0.093073174,0.039016593,0.108070895,-0.024564734,0.006128681,-0.0072067687,-0.024960771,-0.09857413,0.08336788,0.050082885,-4.294732e-08,0.034291595,-0.088622116,0.030786637,-0.023286704,-0.041379847,0.09540838,-0.027250683,0.009792591,0.069568574,-0.016328244,-0.0034286026,-0.008364255,-0.043941323,-0.049988672,-0.048521813,-0.031133283,0.007501528,0.07888067,-0.01361411,-0.044268914,-0.037770692,0.014218328,-0.010952023,-0.05480299,0.014545742,-0.011754222,-0.042134818,0.07773931,0.044762246,-0.089503706,0.058765013,0.029991211,0.037659943,-0.041649204,-0.061930988,-0.013289353,0.035055146,-0.058786597,0.03386832,0.011143471,0.041376516,0.013719164,-0.09398223,0.028938325,0.011870374,-0.017235477,-0.03592616,0.031075511,-0.0017886873,0.00034742334,0.013860539,-0.02596449,0.022017177,-0.07200619,-0.028453264,0.07220714,-0.07196188,-0.010019361,-0.007280969,-0.06534782,0.043445393,0.03667664,0.12983996,-0.052963693 +2.1.1.365,"Requires Mg2+. The enzyme, characterized from the bacterium Mycolicibacterium hassiacum, participates in the biosynthesis of 3-O-methylmannose polysaccharides (MMP), which are intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism in nontuberculous mycobacteria. The methylation catalysed by this enzyme was shown to block the reducing end of 3,3'-di-O-methyl-alpha-mannobiose, a probable early precursor of the 3-O-methylmannose polysaccharides.",384,1.0,0.010671124,-0.034659684,-0.0708603,-0.011826099,-0.015992882,-0.0006010661,-0.027248137,0.052722134,-0.012010499,0.06938251,-0.00047220956,-0.06838667,0.038668837,-0.05902432,-0.037419442,0.016501276,0.052378196,0.029879509,0.018355973,0.01649334,0.11472579,-0.020733071,0.026939113,-0.047101825,0.030933157,0.025700312,0.04979513,-0.06608596,-0.02861459,-0.041105226,-0.015585631,-0.0707655,0.06733295,-0.08672172,0.09152959,0.06461635,0.021038488,-0.034140915,0.07363513,-0.039173875,0.06497589,-0.011973932,0.07243339,-0.0029311655,-0.045207895,-0.039881498,-0.036580216,0.008021236,0.018018236,-0.015493466,-0.091133565,-0.040966995,-0.03330595,0.0021319995,0.029225344,-0.0013673117,0.020748965,0.014000822,-0.0270704,0.045219827,0.0099701835,-0.026070772,0.0445418,-0.0031136503,0.00088622054,-0.040441483,-0.07607798,-0.065472044,0.008733422,0.03447946,-0.06410351,-0.01049315,-0.08281398,0.025847409,0.0048879557,-0.015977819,0.030848999,-0.012199967,0.020576049,0.03779204,-0.011677496,0.004813777,0.058474682,-0.0009978702,-0.030471774,-0.035205662,0.08030784,0.013314956,0.03294564,0.09290011,0.009124931,0.02589493,0.07462092,0.025735274,-0.061004315,-0.053469315,0.028743524,0.0007915026,0.074997105,-0.0542435,0.022594826,-0.018318467,-0.003209149,-0.038726017,-0.04291627,0.045528706,-0.04260936,0.025528032,0.05161124,0.08800634,0.049616236,0.049177986,-0.030964257,-0.0013925802,-0.09616806,0.05860774,0.13729878,-0.13141374,-0.049844436,-0.024873836,-0.030576106,-0.0673609,0.06259984,-0.028217051,-0.06716458,-0.017144578,-0.07826883,1.9636097e-33,-0.01089744,-0.08188941,0.045621544,-0.026665613,0.09621404,-0.011286056,-0.019757312,-0.020024823,-0.0043244655,0.002479741,-0.10736015,-0.12186539,-0.022335561,0.08225779,-0.11526758,0.031199174,-0.0018683204,-0.026600026,0.0728314,0.02117926,-0.06447824,0.019981178,0.06865219,-0.041889276,0.046882663,0.08213829,-0.015274569,-0.062376782,0.07840378,-0.0071616615,0.07933088,-0.14263412,-0.12122912,-0.02766584,0.05459339,0.037312914,-0.022173926,-0.0072902846,0.006767508,0.02762443,-0.041407824,0.018463295,-0.00491854,-0.050382655,0.03594689,0.02983771,0.011141339,0.02012216,-0.028534701,0.03135144,0.068538584,-0.041872736,0.030006174,0.07149878,-0.033934273,-0.025287831,-0.039074875,0.04157699,-0.0020497034,0.05426088,0.032882154,0.043168556,0.031206736,0.064001955,-0.030417887,-0.051253047,-0.021859266,0.017053138,0.026797261,0.026645554,-0.014961367,-0.037013073,0.06425096,-0.030491527,0.0364044,-0.02950966,-0.084326036,-0.0076951766,0.017268686,-0.016215153,0.11197628,0.02291929,0.020506445,-0.03305613,-0.0861931,0.047440648,-0.09281847,-0.035078183,-0.01285307,0.010669814,-0.008610826,-0.04639494,-0.082821675,0.15623555,-0.053301442,-4.382274e-33,0.073800206,-0.08297531,0.114782505,-0.072817236,-0.028202005,-0.0433041,0.04334761,-0.00024307321,-0.0019631486,-0.014189974,0.12990604,-0.009371998,0.006294167,-0.011207065,0.018104076,-0.016062861,-0.012940379,0.089851506,-0.064531006,-0.051319223,0.0068264063,0.050823208,-0.032439068,-0.021343417,-0.0226666,0.013958488,0.00071584753,0.035632268,0.013983509,0.07698146,0.036849495,0.036998544,-0.035453625,-0.11217205,0.0020866147,-0.015803687,-0.113202326,-0.0077147563,0.02763866,0.034084298,-0.036154844,0.03786851,0.04312937,-0.017346509,-0.018797547,-0.02894554,-0.08797856,0.014917675,0.031507008,-0.015284196,-0.022361167,-0.12214673,0.02886472,0.045271046,0.050328992,0.053444885,0.023809724,0.012815379,0.016169736,-0.06336497,-0.076982215,-0.06350211,0.08069786,-0.044396147,0.039296232,0.15509272,0.0018612562,-0.026485234,0.058123264,0.024001015,0.011219067,0.030690206,-0.072684854,0.07702564,0.0068400325,0.012160103,-0.08354367,0.013458414,-0.023399089,-0.0047593787,-0.014100314,-0.024474027,0.016954288,-0.09501066,0.033202596,-0.07710837,0.04648467,0.06471587,-0.04325364,0.08635448,0.007222442,0.05165787,-0.07025022,0.06476283,0.006254637,-4.059363e-08,-0.008268051,-0.09672018,-0.010678527,-0.0052644787,-0.018172875,0.027328243,-0.056766376,-0.03445382,0.044693198,-0.036558427,0.048431456,0.032173872,0.02434994,0.030549565,0.016851988,-0.0051467465,-0.030756671,-0.070455804,0.016606502,-0.05132213,-0.15626226,0.0017166237,-0.027229374,0.008453035,0.04665104,-0.041921455,-0.003801554,0.045225628,0.022207925,0.010944147,0.036922663,0.07866333,0.0072273826,-0.040404316,-0.061887287,0.030380262,-0.046395473,-0.07837584,0.016368229,-0.03202676,0.055244144,0.03619473,0.033500236,0.012554492,-0.0054637077,0.044864833,-0.053479597,0.11448962,-0.06115422,0.03904473,-0.022163343,0.025521846,-0.07390564,0.019877851,-0.029711712,0.0106916325,-0.041393448,0.028819447,-0.03387095,-0.015441258,0.063598074,-0.046515796,0.09506431,-0.0473759 +2.3.2.34,"Some RING-type E3 ubiquitin transferases (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form complexes with a cullin scaffold protein and a substrate recognition module, which are known as CRL (Cullin-RING-Ligase) complexes. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. Like ubiquitin, the NEDD8 protein ends with two glycine residues. EC 6.2.1.64, E1 NEDD8-activating enzyme, activates NEDD8 in an ATP-dependent reaction by forming a high-energy thioester intermediate between NEDD8 and one of its cysteine residues. The activated NEDD8 is subsequently transferred to a cysteine residue of an E2 NEDD8-conjugating enzyme, and is eventually conjugated to a lysine residue of specific substrates in the presence of the appropriate E3 transferase (EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase).",384,1.0,-0.12974498,-0.014760593,-0.025206838,-0.06529861,0.1114044,0.00063425815,-0.0010624048,0.054152347,0.040038068,-0.054979764,-0.014007354,-0.0047412347,0.020922877,0.03902711,-0.026152542,-0.038068578,-0.051886965,0.019846521,-0.06253612,-0.08523684,0.08792447,0.0674401,0.010689375,-0.02434489,-0.0070944494,-0.0352198,0.08833561,0.031059934,0.016806979,-0.09469752,0.0045951204,-0.04608024,-0.038504776,-0.04672198,0.008489839,0.13369165,-0.043790035,-0.029274272,-0.06926891,-0.05356078,0.10791686,-0.031674404,0.035886243,-0.014545541,-0.023314856,0.021772914,0.016553452,0.01145305,0.056838688,-0.016925208,0.032706898,-0.035714775,0.0069730417,0.044475194,0.027345214,0.05471954,-0.07159559,-0.001247132,0.0070396527,-0.022864021,0.022904055,0.004146878,0.049281895,-0.019265054,0.019526755,-0.077824734,0.042988975,-0.04858295,-0.0022320969,-0.020464215,-0.010022554,0.013891579,-0.073406294,0.058492046,-0.022216147,0.07852389,-0.073680826,-0.03367852,-0.0033905315,-0.036502365,-0.021843735,-0.027888596,0.14130293,-0.020557722,0.07345829,0.018331978,-0.043365847,-0.020817392,0.04231285,0.048937473,0.034238387,0.018837506,-0.011290325,0.058958743,-0.013602365,-0.0053594373,0.046509996,0.036678158,-0.063712455,0.044473782,0.023052467,0.12325044,-0.03341717,0.017584031,0.013846998,0.035129666,0.029552624,0.067025505,-0.05579719,-0.008216847,-0.053521313,0.006120015,0.07969571,-0.048095617,-0.008244602,0.095786266,-0.043594334,-0.030622156,0.025683299,-0.023587063,0.00046816416,0.038621422,-0.021049792,0.058612756,-0.018165318,0.03197573,-0.077914335,4.4565132e-33,0.013134437,0.0446625,-0.05169663,0.03387347,-0.06994687,-0.013062241,-0.13787174,0.028997935,-0.013823674,-0.06480295,-0.037856717,0.008547021,0.055348415,0.034014642,-0.014267782,-0.06727135,0.005687239,-0.0077805137,0.03561939,0.026803555,0.010307412,-0.01301558,-0.02737806,-0.0005682523,0.001221101,0.027714789,-0.005380931,0.06251289,0.079774074,0.0039370405,-0.033172045,-0.06544493,-0.07644504,-0.0040223296,0.012839428,-0.003748361,-0.014435359,-0.020633,0.024828147,0.031240525,0.056194946,-0.012525155,-0.095665626,-0.04787497,0.039171882,-0.05957438,-0.019115485,0.08666698,-0.041004628,-0.026573693,0.12963451,-0.06537026,0.050394494,-0.08593007,-0.076017976,-0.023420043,-0.0026467978,0.0016525796,0.03639849,0.024988418,0.031421203,0.021787547,-0.033115897,0.07434795,0.03237748,0.09917964,-0.099438734,-0.099896595,-0.0046494096,0.046888687,-0.05069418,-0.020941934,0.08270026,0.006150178,0.049374357,-0.07201034,-0.09831534,-0.013614432,0.04362955,0.081773914,-0.023835424,-0.0012978934,-0.09810239,-0.038547613,-0.029459702,-0.06252404,-0.012056922,-0.061311666,-0.00064805616,-0.016871983,0.13665825,-0.062746294,0.008375951,0.051945865,0.027597124,-4.7521086e-33,0.07238009,-0.035022423,0.05963038,0.006712346,0.021294875,0.062001523,0.07315432,-0.03346636,0.03570882,-0.105513185,0.08533535,-0.09054024,-0.025580933,-0.015599116,0.02045886,-0.04486945,-0.04899631,0.061943598,0.02633584,-0.008324781,-0.017422503,-0.0010408055,-0.0069762776,0.07537235,-0.003619436,0.044714402,-0.09435001,0.044613473,-0.024926027,0.03936202,-0.026994605,-0.029494615,-0.06964291,0.12889393,-0.07043626,0.07331364,-0.009533036,0.008966065,0.06857454,-0.057008136,0.09812533,-0.006888029,-0.05082432,0.106784165,-0.005074534,0.07238628,-0.04339624,0.04049994,-0.043121986,-0.04906326,0.035740335,0.06916474,-0.07577685,-0.022941355,-0.031178484,0.099076495,0.09659954,-0.042209882,0.04486275,0.035741646,0.007521169,-0.0049025444,0.0034044078,0.030349795,0.024119701,0.0092792725,-0.024411775,0.10358562,0.08025214,0.014717472,0.044894766,0.014511079,0.065927364,-0.028109027,0.05605938,0.014731996,-0.010939358,-0.0054056426,-0.018801838,-0.061292183,-0.082326725,-0.02954573,-0.0016240546,-0.032009378,0.0011955311,-0.020336948,0.012792991,0.048630156,0.039950285,-0.027364168,6.0897964e-05,-0.036755756,-0.0011321957,0.10885504,0.10591917,-4.5261483e-08,0.059732005,-0.055947326,0.024874615,-0.09121493,0.034716457,0.021174764,-0.0196179,0.029565208,0.034345273,-0.043659054,-0.05395474,0.052196585,-0.032603066,-0.05267977,0.04814751,0.10006385,-0.030365191,0.06065281,0.010004032,-0.07172038,0.0010493265,-0.015582357,-0.08078785,0.042996272,-0.030091658,-0.04753569,0.020692196,0.10515335,-0.018821858,-0.04825323,0.0015641792,0.0038491578,-0.020266669,-0.024907501,-0.016670536,0.044363905,-0.011521288,-0.03826986,-0.051348813,-0.033706497,-0.020067133,-0.0075878,-0.09086991,-0.06069249,0.03146431,0.010397013,0.03774146,0.025409682,-0.068296336,-0.005525278,-0.01641318,-0.016663417,0.020382278,-0.0744276,-0.067979254,-0.016022094,-0.08028545,-0.1035077,-0.008298064,-0.086382724,-0.006565726,0.0071587553,0.06799814,-0.061598293 +2.3.2.35,"The enzyme, found only in plants that belong to the Capsicum genus, catalyses the last step in the biosynthesis of capsaicinoids. The enzyme catalyses the acylation of vanillylamine by a branched-chain fatty acid. The exact structure of the fatty acid determines the type of capsaicinoid formed.",384,1.0,-0.017071636,-0.024980636,-0.12326335,-0.012310856,0.106837146,0.059905592,-0.09007688,0.0012087212,0.011756391,-0.04045049,0.10189496,-0.11286991,-0.0055615385,-0.047250643,-0.04071806,-0.04222782,-0.15173292,0.023406347,-0.008492592,-0.122278035,0.043094218,0.06914303,0.038728848,-0.0039680805,0.032060944,0.0048296163,0.002748282,-0.040344317,-0.02895809,-0.086686596,0.03607176,-0.051859647,0.026632218,-0.035860147,0.05289548,0.06587301,-0.080584206,0.0058468897,0.11134813,0.028279766,-0.0071382285,-0.04547024,-0.00046216836,0.0037116283,-0.01305065,-0.043039214,0.004922339,-0.026599325,-0.00089633954,-0.043496232,-0.005346616,-0.022700213,-0.0015574015,-0.010923632,-0.049934898,0.042099945,-0.009645371,-0.0242766,-0.02167375,0.075968534,0.06579961,-0.024711933,-0.050463933,-0.007345979,0.003574364,-0.03706571,-0.000838648,-0.06955978,0.05864701,-0.022842575,-0.01969226,-0.09495551,-0.04837701,0.024593676,0.011169178,0.036804557,-0.03417905,0.0075275465,-0.017201113,0.013269363,-0.041196097,0.015502225,0.042023145,0.08307871,0.02876231,0.0067884,0.020849923,0.014343233,0.062067993,0.041269187,0.029121038,0.025905685,-0.009578568,-0.0011777873,-0.064206876,0.054508116,0.049658384,-0.0121937115,0.043089792,-0.0040117316,-0.021575764,-0.005052184,-0.088535145,-0.100873455,-0.02205958,0.034024395,-0.03466631,0.03359222,-0.05675573,-0.04296899,0.026281554,-0.012470676,-0.0126054445,0.026741907,0.045569804,0.09381872,0.06550207,-0.049650483,-0.100515194,-0.039567027,-0.057651702,-0.06378349,0.014177539,0.03259579,-0.049224798,0.09736989,-0.14289679,8.379956e-34,0.043165993,0.07213677,-0.027614728,-0.06940824,-0.03489459,-0.008931801,-0.050417732,0.03096666,-0.030842103,-0.016969694,-0.05276352,-0.034994803,-0.015163318,-0.030084359,-0.00052003574,-0.05905805,0.027075332,0.06083689,-0.033501357,-0.045636386,-0.029361233,0.093881145,0.0024290816,-0.03287757,-0.03870931,0.0967861,0.012419335,-0.04711825,0.064721264,0.022560006,-0.025091058,-0.034028064,-0.06538438,0.028402608,0.058163416,0.03265405,-0.054779604,-0.056503724,-0.048047196,0.079075396,0.025436524,0.06370737,0.028274368,-0.023177765,-0.02989867,0.020600002,-0.04312918,0.103916034,0.06942116,0.052497055,-0.019669367,0.01918371,0.12854245,0.019636357,0.008569235,0.027144095,-0.03159474,0.060675573,0.037004475,0.03183321,0.009043412,-0.028320894,-0.03515605,0.023210747,-0.010319602,0.06523481,-0.0790017,-0.04224204,0.039708633,0.03753326,-0.013109566,-0.0048173536,-0.016135126,0.07934032,0.10492883,-0.01633516,-0.02043274,0.038129658,0.003300978,-0.007975877,-0.023030736,0.055428594,-0.01889435,-0.014367607,0.028708424,-0.03736495,-0.07956473,-0.014803689,0.040141374,0.06891955,-0.033401318,-0.016141662,-0.026345123,0.043754414,0.025969781,-1.0488267e-33,0.07334542,-0.101491585,-0.029201351,-0.07738343,-0.019000497,0.029318491,-0.087160245,-0.082166076,0.010174444,-0.008470569,0.024317918,0.0002369007,0.005464948,-0.038524363,-0.02137107,0.0007797583,0.11036296,0.12368967,0.0051529785,-0.029139895,-0.06579941,0.0576956,-0.061966028,0.02739034,0.042275075,0.052098587,-0.023968842,0.032178182,0.020126838,0.019702144,-0.018908434,0.019008908,0.009919616,0.010333079,-0.02088632,0.06937704,-0.031402007,-0.012281259,0.083014324,0.12743522,-0.043292176,0.015154729,0.07921325,0.025673298,0.08113155,-0.05420564,-0.026845848,0.050791252,-0.03682859,-0.027722474,0.068187274,-0.018822398,0.027968694,-0.0264982,0.02833135,0.055066887,0.034695305,0.024627967,0.030825885,-0.08078205,-0.016060157,-0.07631136,0.0021764657,0.035756394,-0.013117344,0.021165665,-0.04856481,0.03161401,-0.0044679977,-0.020296138,0.07009199,-0.013522355,0.029329725,0.078896835,0.004668785,-0.021516677,-0.009871414,-0.04904418,-0.006474125,-0.06264067,-0.029872522,0.02070042,0.045542546,-0.08665414,-0.050568946,-0.024747482,0.074368626,0.017601315,0.012977342,0.032249894,-0.018352142,-0.0097081,-0.0399819,0.14246657,0.15052384,-3.171039e-08,0.039200787,-0.033505283,0.03591723,0.020158479,0.02202271,0.08905754,0.03796496,-0.0059597287,0.03737231,-0.09867256,-0.038254037,0.11631806,0.06192538,0.020627707,-0.01305143,0.04537415,0.03601285,0.040650003,-0.04956928,0.05911375,-0.06786228,0.0061718696,-0.053335268,-0.030562777,-0.0409838,-0.042494897,-0.01936914,0.058755655,-0.011493001,-0.023962053,0.06270895,0.005145501,-0.029538896,-0.06910552,-0.013173774,0.046791036,0.018136375,-0.122762665,0.031364147,0.010918035,-0.009195458,-0.021998134,-0.047728833,0.014343321,-0.050405517,0.023699507,-0.01609858,0.0042883097,-0.056519806,0.05967318,-0.014572837,-0.04738033,0.015848394,-0.056120086,-0.06621401,-0.019744972,0.036547497,-0.025800092,-0.024707338,-0.047324322,-0.053691983,0.069101214,0.2351678,-0.023618508 +2.4.1.375,"The enzyme, characterized from the plant Vigna angularis (azuki beans), participates in the biosynthesis of rhamnogalacturonan I, one of the components of pectin in plant cell wall. It does not require any metal ions, and prefers substrates with a degree of polymerization larger than 9.",384,1.0,-0.055054057,-0.0035786354,-0.13018006,-0.028669102,0.086292304,0.04681188,-0.00065175875,0.0017173394,0.050176248,0.005473444,0.08034791,-0.016884334,-0.0051564565,-0.046573542,-0.07451878,-0.037075285,-0.030359885,0.07785704,-0.045428805,-0.032261964,0.04757876,0.031170541,0.03273527,-0.014580325,-0.010625077,0.016652884,0.0012165377,0.018612335,0.022147454,-0.049879424,-0.04257201,0.010827382,0.024511939,-0.035935987,-0.049345102,0.11166591,-0.020640628,-0.052181583,0.056629993,-0.061521966,0.08052434,-0.04097014,0.056271385,-0.0013453929,0.03842554,-0.046520032,0.001830443,-0.023914656,0.002248074,-0.033822753,-0.06880752,-0.035041295,0.002639284,0.018032093,0.02289602,-0.024790436,-0.05518303,-0.028825434,-0.02149586,0.057140503,0.075537615,0.03468185,-0.0059888912,0.020688802,-0.08635994,-0.07653858,-0.07027425,-0.0076488093,-0.00546581,-0.017785063,0.010011026,-0.020277381,-0.03284613,-0.056346193,0.021797726,0.09862221,-0.0053064707,-0.055942535,-0.026472468,0.041123487,0.01228013,0.043766048,0.056842614,0.035584815,-0.023698945,-0.0046824226,0.070727214,0.0354938,-0.049045518,0.03998199,0.10910459,0.016032116,0.025868349,-0.0003237783,-0.019143187,0.025808735,-0.04817487,-0.09282665,0.0038011146,-0.010973965,-0.061751336,0.031728845,0.100788295,-0.07632198,-0.06602586,0.033485338,-0.07604679,0.03677254,0.02093201,0.005841405,-0.0130367745,-0.030614527,-0.08491221,0.027587643,-0.029230712,0.063581854,0.0025753395,-0.07143941,-0.019709341,-0.005484713,0.021816391,-0.022297034,-0.033247534,0.027545802,-0.052303445,-0.041570093,-0.10995247,7.4455785e-34,0.015176507,-0.019275816,-0.03268546,-0.06603974,0.027328774,0.00464131,-0.04316056,-0.035037324,0.03091395,-0.025269805,-0.13828309,-0.063974656,0.01810088,0.08930431,-0.024451433,0.00041867382,-0.055680856,-0.069501296,0.08179243,0.039054748,0.060242668,0.0220034,-0.137952,-0.0068793828,-0.009358248,0.048812773,0.04249861,-0.07327246,-0.03699563,-0.02658826,0.096253596,-0.010849221,-0.07481477,0.059268836,0.047289256,0.020792028,0.014341134,-0.031722035,-0.027242593,0.03581187,-0.003041461,0.015075534,0.02654269,0.035931397,0.072539076,-0.017137377,-0.017539142,0.07922756,0.0746899,0.11061522,0.024149438,0.06355895,0.08913223,0.012792631,-0.021384614,0.009898947,-0.010231971,0.081253,-0.01725398,-0.014710443,-0.079895556,-0.019571535,-0.0016887167,0.06833078,-0.024318844,0.07585,-0.08980185,-0.09114728,0.032403573,0.04732733,-0.03759492,-0.016612845,0.0063471147,-0.06240775,0.04333679,-0.034973066,-0.048363246,0.03012726,-0.017098472,0.06598202,-0.013911169,0.04737086,-0.00047807017,-0.016578652,-0.025640568,0.01898556,-0.05209807,0.024479628,0.05903148,0.017356714,0.091482595,0.0029350666,-0.05495809,0.06447023,-0.011688982,-1.7585801e-33,0.08150851,-0.11211566,0.12522171,0.054086745,-0.029256519,0.01586957,-0.019398576,0.015502773,0.008849199,-0.023061447,0.037305806,0.013607357,0.043681644,0.028358882,0.040041596,0.04867641,-0.031912804,0.098798275,0.012883353,0.01979544,-0.13598928,0.07391904,0.040994875,0.0032629617,0.09319244,-0.0006956975,0.03471057,0.01280426,-0.042001702,0.0033630016,-0.029195143,-0.06824394,-0.099608816,-0.032511536,-0.052835096,0.052461583,-0.015724123,-0.019339347,-0.002365954,0.07342433,0.042063914,0.03970302,0.024478586,0.052387882,-0.015970152,0.023573289,-0.04453194,0.07213196,-0.04696619,-0.053075414,0.0015633302,0.08070456,0.032445934,0.012235172,0.08686792,0.05655585,0.040027827,0.070585944,-0.017995464,0.015271137,-0.013325716,-0.09619367,0.049322918,-0.032607403,0.029478362,0.072502926,0.07780607,0.060615636,0.05859731,-0.011684589,0.13506375,0.06984562,0.02887891,0.048260517,0.008239249,-0.0036057925,-0.03337635,-0.06996367,-0.074313626,-0.0050211996,0.087056376,0.010194292,-0.048316058,-0.103354715,-0.0054423097,-0.03199882,0.032368116,0.08586895,-0.004083461,0.011623723,0.025109814,-0.001001015,-0.094635,0.027138984,0.06455651,-3.47469e-08,-0.008734109,-0.047192894,0.009162646,-0.09794037,-0.0046833153,-0.02927003,0.0579359,-0.011631023,0.0010465605,-0.00029791,0.019929664,0.07316483,-0.04104499,0.02312802,0.021697495,0.0012284319,-0.002418866,0.045584682,-0.0025384822,0.07990532,-0.056104753,-0.03216301,-0.12229175,0.01197577,-0.027166387,-0.065996625,0.016440235,0.013987711,-0.0012105865,0.0052476986,0.02215115,0.06182993,-0.0012929441,-0.042948104,-0.15354748,0.01948865,0.004682966,-0.07243413,-0.047585383,-0.07216957,0.0060911234,-0.0730598,-0.005025247,-0.052830406,-0.08302821,-0.03708179,-0.007933589,0.008845053,0.028009126,-0.04144816,0.010496884,0.0009028983,0.027237384,-0.06392501,-0.07165863,-0.009410083,0.06843389,-0.031796478,0.021193452,-0.021153057,-0.07198776,-0.004879424,0.1571708,-0.07581299 +2.4.1.376,"The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. Glycosylation takes place at the serine in the C-X-S-X-P-C motif. The enzyme is bifunctional also being active with UDP-alpha-xylose as donor (EC 2.4.2.63, EGF-domain serine xylosyltransferase). When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.",384,1.0,-0.026665382,-0.04393169,-0.101510875,-0.052612647,0.0037844444,0.051986057,0.033646215,0.055323273,0.0018770306,0.07125694,0.116487384,-0.010239342,-0.09082995,0.03343212,-0.012574833,0.03232161,-0.04862817,0.017389825,-0.019528367,-0.082271755,0.06311937,-0.029034523,0.013710084,-0.00029548665,0.017774235,-0.059588734,-0.02277388,-0.065198325,-0.004936921,-0.06531069,-0.070047006,-0.009835654,0.001405493,-0.047939505,0.02757233,0.034428857,0.003272978,-0.039540853,0.005396086,0.00398491,0.0560883,-0.019063443,-0.016112752,-0.033606812,-0.069692634,-0.04219748,-0.007931852,0.07850069,0.039179567,0.004021619,0.027576633,-0.0811685,-0.03648023,-0.032112114,0.026365502,0.011526667,-0.055980418,-0.0076203616,0.02503602,0.04798635,-0.005345978,-0.0014934909,0.041683324,0.042447887,-0.02507303,-0.094913416,0.072185285,-0.082851864,-0.056744043,0.0013342467,-0.064626105,-0.06664841,-0.02241857,0.020563705,0.04292097,0.015871638,-0.01094595,0.040193483,0.04028454,0.020818846,0.0007972245,0.060199857,0.054055642,0.08007003,-0.02899177,-0.022189172,-0.03767762,-0.020895967,-0.056052607,0.08567347,0.053061392,-0.06584587,-0.021671815,0.050731495,-0.0088291345,-0.03293928,0.061899513,-0.05203261,0.015693542,-0.054607593,-0.07577124,0.023920583,0.049195204,-0.040387172,-0.03928291,0.008847353,-0.06126773,0.05746537,0.024770327,0.008819312,-0.0777044,0.0007846771,0.066147104,0.056249842,-0.08178116,0.028039765,-0.0053820843,-0.078996025,0.046294358,-0.06720629,0.053971987,0.027764667,0.0064747734,0.07657851,-0.028332023,0.040024035,-0.0038427608,-6.911825e-34,0.0753701,0.068321414,-0.033938184,-0.0028764275,-0.0064252173,-0.0042779064,-0.021838024,0.027560115,-0.10073419,0.038578533,-0.05363252,-0.058448162,0.080969,0.13122661,0.0031212324,0.03865361,0.01272215,-0.05327342,0.06670656,0.013250208,-0.06296137,0.017743763,0.013889311,-0.022617878,0.058511667,0.10638561,-0.082973436,0.023335353,0.020533537,0.013629699,-0.0057185343,-0.07113702,-0.014333146,0.036662098,0.087382,0.041329518,0.07613185,-0.068608515,-0.013060259,0.021081395,0.09587928,-0.018084612,-0.046028905,-0.061531376,-0.01770373,-0.06531888,-0.08536085,0.0438634,-0.02935469,0.04503378,0.0921218,0.023864215,0.1247281,0.08061599,-0.03786908,0.048112378,-0.07462331,-0.04455674,-0.052142676,0.008725455,-0.032384895,-0.014404441,0.039334733,0.021353137,0.06610774,0.025251096,-0.04812762,-0.08309938,-0.04219591,-0.013913067,-0.017728653,-0.07343249,0.09083769,-0.020122495,-0.01782001,-0.053348646,-0.06737458,0.123339765,0.044274252,0.028232362,0.059052307,0.061772782,0.03751878,-0.023776274,0.015225209,-0.04392379,-0.042036936,-0.034953382,0.007891186,0.030540979,-0.057845373,-0.033247314,0.017127039,0.09193118,0.028083267,-2.885187e-33,0.063717335,-0.044614624,0.04622991,-0.041922662,-0.04084752,0.092064396,0.030595865,0.000100167475,0.026620913,-0.030155567,0.043095436,0.047445685,-0.024033757,-0.052378453,0.009761204,0.0075350627,-0.02519774,0.038694177,-0.04804127,-0.063747086,-0.009210394,0.008111967,-0.013333844,0.0038682085,0.03623938,-0.028149351,-0.03345257,0.03400011,-0.046418462,-0.0018756394,0.020932555,-0.03148521,-0.048340145,-0.09844338,-0.008892937,0.007851279,-0.040761214,0.025638906,-0.005215464,-0.00041052722,0.054059364,0.032555077,0.1096779,-0.022521487,0.1179313,0.1017103,-0.04097349,0.053509843,-0.018787423,0.055335257,-0.016684052,0.07239228,0.047884997,0.06897495,-0.019176837,0.11415848,0.02531248,0.023058983,-0.012121913,-0.018956296,-0.039327912,-0.09975706,0.011029606,0.07010798,0.030808667,-0.026168644,-0.008229428,-0.063273154,0.024614643,-0.038656376,0.07357564,-0.025077464,-0.06024889,-0.011578327,-0.106586866,-0.0010194284,-0.06516159,-0.038293436,0.028505424,0.014649577,-0.004438324,0.02248835,0.04917948,-0.029667238,0.047819994,-0.0008538053,-0.03478696,0.14921442,0.0015121584,-0.05692788,-0.030885873,-0.11687865,-0.102943,-0.03932912,0.093725905,-4.4056037e-08,0.052805778,-0.030676449,-0.039567776,-0.06795055,-0.02089355,0.026501438,0.018872736,0.006711529,-0.031850617,-0.032471653,0.011717595,0.050415326,-0.058313712,0.04853096,-0.03349729,-0.004374195,0.051584605,0.098442666,-0.021192113,-0.05166438,-0.1046395,-0.006825509,-0.0053437147,0.01710031,-0.04206334,-0.15971123,0.03416558,0.10228152,-0.04443893,0.00608907,-0.021868953,0.042055476,-0.0025464722,-0.029720841,-0.032613065,-0.034888018,-0.0050388733,-0.04535036,0.051258564,-0.024472496,0.01172098,-0.016642235,0.015655447,-0.03758429,-0.014949261,0.05854228,0.10449673,0.03698234,-0.016782722,0.038961705,-0.008427504,0.03755169,-0.055893358,-0.13750368,-0.110945225,0.030228037,0.00044418042,-0.006037435,0.05635631,-0.042651426,-0.007960238,-0.034126904,0.08122831,-0.042799663 +2.4.2.62,"The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.",384,0.99999994,-0.038750984,-0.04305405,-0.08558571,-0.046943124,-0.031196158,0.05723038,0.050791603,0.03445979,-0.00391838,0.123480506,0.09305674,-0.07263138,-0.07572263,0.023961425,-0.015332095,0.0361531,-0.045554634,0.02341086,0.0028782967,-0.1244843,0.023034854,-0.005714684,-0.007538988,-0.001510958,0.02311172,-0.047818687,0.0051271487,-0.02698249,-0.006721622,-0.08209719,-0.03955346,-0.01423041,0.002778086,-0.05179772,-0.01138788,0.035441138,0.011763363,-0.0532119,0.02582604,0.030303013,0.060124513,0.013236228,-0.00018794012,-0.022012789,-0.036038257,-0.0047421944,-0.044644922,0.10428975,0.049678586,-0.01462728,0.028435558,-0.07965816,-0.04354513,-0.01606606,0.0025690377,-0.0049200878,-0.037255403,0.0076380195,0.03449775,0.07283466,0.009492061,-0.040723007,0.02323542,0.05792245,-0.030253695,-0.09043369,0.03504609,-0.06100446,-0.06717844,0.012281276,-0.043918554,-0.07431512,-0.037409212,0.010351395,0.03204702,-0.015685268,-0.036362357,0.04350481,0.023864688,0.039690837,-0.012327017,0.04865742,0.06179624,0.08256084,-0.006413866,-0.018830197,-0.03179742,-0.058625188,-0.05466387,0.07771755,0.066959895,-0.0516759,-0.0139237605,0.0654659,-0.0241083,-0.011388216,0.031538326,-0.08719793,0.02216771,-0.06367381,-0.072873004,-0.020500284,0.028757226,-0.027668085,-0.017043259,0.029689038,-0.043880966,0.050120533,0.045075223,0.027842252,-0.05905267,0.0070565785,0.033902325,0.046733107,-0.083378434,0.036501907,0.005471616,-0.10809293,0.06852859,-0.047012467,0.041129496,0.0006444321,-0.016361179,0.05684605,-0.06655349,0.005462096,0.00021511476,-1.7407082e-33,0.07520239,0.030950543,-0.06532546,0.0050080656,0.0235252,0.043826263,-0.047793802,-0.014324325,-0.08657075,0.0143972635,-0.05988409,-0.050945826,0.07797323,0.14069283,0.020222656,0.06291797,0.0093396,-0.048029505,0.060453705,-0.012424291,-0.08321699,-0.0031826945,-0.021344448,0.025558282,0.060926486,0.14020748,-0.048928607,-0.0054483204,0.038349457,0.008196751,0.0017958778,-0.04003042,-0.02238435,0.035891324,0.06880275,0.0135013675,0.07764205,-0.040623546,-0.027121074,-0.002368544,0.118771054,-0.028991934,-0.044051234,-0.07208086,-0.022331998,-0.087475,-0.052636195,0.07061838,-0.045723613,0.058080725,0.11517743,0.06551958,0.13328731,0.07621511,-0.055395085,0.062919855,-0.09641231,-0.04358068,-0.013453982,-0.0019066954,-0.061563052,-0.027453326,0.048735082,0.053537704,0.057103936,0.037124407,-0.01817023,-0.10333756,-0.02357298,0.00835948,-0.006179589,-0.08374744,0.05344845,-0.031002356,-0.048741188,-0.037311576,-0.062314965,0.07560505,0.040123634,0.023628095,0.08866682,0.057202782,0.056123804,-0.028304582,0.0281578,-0.058950484,-0.052335966,-0.023471475,0.016145153,0.0056416225,-0.04098989,-0.000663723,0.0065319436,0.117305055,0.021879446,-1.6398875e-33,0.06918594,-0.05086266,0.05026249,-0.05545499,-0.026724773,0.08572508,0.0027684565,0.009815826,0.032002073,-0.01843648,0.068734504,0.042033967,-0.052154925,-0.024715086,0.036687937,0.010502989,-0.024655467,0.029669799,-0.041086245,-0.056493003,-0.017839462,-0.025180101,0.003237935,-0.0006132646,0.0137666315,-0.016781604,-0.043034516,-0.0004171102,-0.042437565,0.01767889,0.0005284539,-0.0659149,-0.042155012,-0.059075627,0.018419016,0.018537186,-0.006308846,0.028103627,-0.0100014685,-0.00065793225,0.071652964,0.02660879,0.097517975,-0.034045458,0.09099901,0.06498734,-0.019236121,0.07303515,-0.07548111,0.033608977,0.0018426868,0.071896166,0.06728365,0.06112447,-0.01609887,0.083076894,0.029982515,0.007350116,-0.014640521,-0.025745943,-0.022926828,-0.10485143,0.028645096,0.05067128,0.04193457,0.0024279153,-0.02153032,-0.055984195,0.0115305055,-0.01178234,0.091107525,0.0033488492,-0.045313753,-0.029741177,-0.12645122,-0.0129396515,-0.038368836,-0.029985517,0.016665637,0.06127367,0.009304174,0.028942158,0.02991451,-0.039788675,0.015222643,-0.0029766005,-0.05873539,0.12307177,-0.00079079205,-0.040135395,-0.03085335,-0.10345483,-0.106770635,-0.024157766,0.0689047,-3.6290192e-08,0.043843858,-0.026143584,-0.041210487,-0.06996624,-0.017175168,0.03004211,0.026438044,-0.004419149,-0.038104188,-0.019094296,0.040387742,0.05707657,-0.05498073,0.10176779,-0.010082986,0.0031981964,0.07312255,0.086353764,-0.0071667866,-0.040761065,-0.07340139,0.02728537,0.028220063,-0.006152292,-0.07293695,-0.16067193,0.016631108,0.07340353,-0.035534486,0.01635912,-0.012660624,0.05870442,0.009804589,-0.05394854,-0.030752737,-0.03487037,0.007050861,-0.04423089,0.01834107,-0.028216295,0.02244008,0.02952979,0.020035187,-0.048337933,-0.057223078,0.03343734,0.0983084,0.043973856,0.0058119157,0.06073616,-0.026713392,0.052693516,-0.048952766,-0.114785194,-0.13386242,0.011362172,-0.00029968933,-0.010631884,0.012119719,-0.043581627,-0.016238531,-0.041327488,0.06438189,-0.015510493 +2.4.2.63,"The enzyme, found in animals and insects, xylosylates at the serine in the C-X-S-X-P-C motif of epidermal growth factor-like (EGF-like) domains. The enzyme is bifunctional also being active with UDP-alpha-glucose as donor (EC 2.4.1.376, EGF-domain serine glucosyltransferase).",384,1.0,-0.0070766923,-0.031300712,-0.08074078,-0.032266784,0.082179405,0.054373443,0.052716497,0.067852765,-0.0009266931,0.016142806,0.13585755,-0.025330594,-0.0932014,0.056074053,-0.0038129294,0.06398752,-0.0683492,0.0132872155,0.013803807,-0.045847625,0.09927062,0.005859495,0.052611288,-0.018748373,0.0048643015,-0.053768475,0.0057166847,-0.079710476,-0.052310254,-0.035525307,-0.040201176,-0.0010371198,0.020589598,-0.027302805,0.049868125,0.04562483,-0.040246647,-0.079066545,-0.018472867,-0.027498426,0.05970274,-0.042398643,-0.0068766996,-0.035153247,-0.07140093,-0.07603213,0.03179291,0.07661188,0.057747755,0.0043954602,0.022157982,-0.123518236,-0.012847161,-0.016018543,0.028796535,-0.008791402,-0.07485225,-0.049748935,-0.03640028,-0.02152436,0.0022101847,0.048197072,0.05211278,-0.011285956,0.03688072,-0.055342358,0.08403212,-0.13650648,-0.05081747,-0.045370024,-0.08415823,-0.069434874,-0.0046866443,0.05461012,0.021211157,0.033228442,-0.036094714,0.027275974,0.056962904,0.03099547,0.023844332,0.034949757,0.032828584,0.06672203,-0.011159997,0.0135508645,0.00864915,0.01856864,0.0018685599,0.036222484,0.0322193,-0.06877425,-0.088140234,0.012395692,-0.0117115695,-0.0366364,0.049175564,-0.03237157,0.028774953,-0.04019147,-0.04387378,0.026385376,0.054898057,-0.010063322,-0.087693945,-0.036174554,-0.08566152,0.08897213,-0.027923003,-0.03790637,-0.08739596,-0.015492354,0.07067796,0.06637144,-0.02529388,0.033357874,-0.019870589,-0.057405546,-0.011556609,-0.026216887,0.06379605,0.08600717,-0.0052605267,0.091882244,0.002142231,0.07993866,-0.055314098,-9.355644e-34,0.039785855,0.06976196,0.01959093,-0.06474338,-0.01974612,0.008043532,-0.00869332,0.06923275,-0.07807713,-0.020350898,-0.116881765,-0.008304453,0.081445195,0.05652942,-0.0018521737,-0.0022699095,0.025064303,0.016908934,0.1324836,-0.0053512296,-0.024049854,0.08368985,0.04317207,-0.0366778,-0.026363624,0.04342089,-0.0868976,0.034797344,0.030898798,0.0006324119,-0.0082504405,-0.101278424,-0.004128369,0.023891123,0.071778566,0.04331191,0.035814874,-0.10032048,0.014427925,0.016166516,0.09943007,-0.029866543,0.0024607128,-0.046274602,-0.0165313,-0.05138088,-0.10479844,-0.018701345,0.02551265,0.0070986366,0.08829888,-0.0011577273,0.0954431,0.02682827,0.0045662518,0.047822982,-0.055181522,-0.00024112998,-0.056687403,-0.020835813,-0.034069505,-0.006485571,-0.0064775823,-0.010994372,0.01955696,-0.028008487,-0.06401666,-0.064747825,-0.07273651,0.049784984,0.0034278752,-0.032117207,0.1119299,0.006150032,0.012675181,-0.032609686,-0.08582334,0.13659231,-0.009953651,0.04620152,-0.00077196176,0.04142424,0.0014472752,-0.011176992,-0.0050359494,-0.031501696,-0.01053306,0.025905063,-0.011765212,0.008777035,-0.0498627,-0.060601853,-0.026848309,0.030865429,0.06108808,-2.2210306e-33,0.0391159,-0.08186959,0.055887856,-0.017279927,-0.027467351,0.08008852,0.061274502,-0.010160659,0.031218367,0.020395603,0.018449506,0.0443145,0.040477265,-0.11523333,0.03457296,0.004213952,-0.014141797,0.08185483,-0.021063698,-0.08739637,-0.043174077,0.057836954,0.025842672,0.015122316,0.037944525,-0.038586125,-0.012198508,0.051722914,-0.04010359,-0.013617113,0.01784293,-0.02703534,-0.005578261,-0.04979571,0.003947621,-0.028631179,-0.0327539,-0.006193349,0.012655962,0.03640675,0.019466093,0.015250555,0.07972972,0.027429499,0.093544856,0.11687848,-0.0478743,0.051668,0.029052546,0.013472666,-0.012915718,0.04554454,0.02045374,-0.055510756,0.015085651,0.1448071,0.013197192,-0.009126734,0.0044816635,0.0014642024,-0.031227179,-0.080677316,-0.006723806,0.046492178,0.006915528,-0.038631953,-0.008187276,-0.035650946,0.03085124,-0.013067304,0.0760155,-0.000376213,-0.052862335,0.05492607,-0.101379596,-0.0022082569,-0.058464818,-0.023793602,0.030121734,-0.06491471,0.023510905,-0.025957022,0.058207314,-0.05352108,0.036572054,-0.016429635,-0.00507018,0.11983293,0.013583649,-0.028411122,-0.03142204,-0.042370405,-0.08331333,-0.027446229,0.121324815,-4.043079e-08,0.027518697,-0.029240198,0.027089352,-0.035484593,-0.018771647,0.015308778,0.032923736,-0.0046119,0.05438043,-0.008664742,-0.030963149,0.020885443,-0.023496987,0.03784243,-0.015283836,-0.075474896,0.038947806,0.065830655,-0.042129755,-0.070839494,-0.100505084,-0.0080624465,-0.02542641,-0.004272277,0.009212619,-0.16176413,0.04066944,0.079730354,-0.09047885,0.0029753644,-0.01504381,-0.013607754,0.025916355,-0.015402681,-0.03281924,0.034912854,-0.018747823,-0.07195859,0.045332722,0.04507407,0.005625286,-0.066182405,0.026907539,-0.05037088,-0.005518361,0.07555342,0.06722416,0.011029629,-0.024674885,-0.018625349,0.010985784,-0.008658017,-0.101142526,-0.105316155,-0.03685096,0.04220755,-0.02675384,-0.036168687,0.0916251,-0.06878845,0.00572293,0.0094277905,0.12393548,-0.0065849284 +2.4.99.22,"Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-beta-D-glucosamine. The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl residues, but more slowly.",384,1.0,0.017471725,-0.13988203,-0.091850616,-0.0027538263,0.03303591,0.05509229,-0.022418309,0.0046438905,0.05108442,0.012783988,0.040687196,0.1069128,-0.06764852,0.08137683,-0.07886241,0.025908483,-0.03639047,0.0032079753,-0.008145543,-0.0014597345,0.026545936,0.003200565,-0.028719448,-0.09038032,0.06215854,0.0025882982,0.114221126,-0.03597983,0.015840312,-0.060733043,0.020221712,-0.06562333,-0.013923124,0.010895516,0.027248483,0.011209423,-0.050398245,0.016129423,0.06976777,0.066780694,0.010067946,0.0125448555,-0.021378199,-0.01197109,0.007846161,-0.03764473,-0.042333487,0.047870636,0.08451734,0.048164792,0.01622874,-0.044868413,0.05122659,0.028042944,0.0003673412,0.07924078,-0.09607067,-0.058896847,0.0030759352,0.08307407,0.032344904,0.054827854,0.030257152,-0.026552526,0.06315481,-0.05008918,0.034686036,-0.04499594,-0.06677512,-0.051061973,-0.062501475,-0.023513626,0.015288439,-0.04496598,-0.019349966,-0.06688547,-0.10308738,0.014714063,0.07262973,-0.042191654,0.031139538,0.010054975,0.028097324,0.072960116,-0.02109785,0.06764466,-0.023192264,0.05593413,0.020296892,0.03849361,-0.023570355,-0.093754925,0.004892266,-0.065424286,-0.010959011,-0.019538704,0.020245854,0.0027889092,-0.030608626,0.014475097,-0.0048815026,0.08333173,0.0008683478,-0.05591786,-0.047271304,0.06424559,-0.0060475683,0.070103996,0.027593467,-0.012091224,-0.03874027,0.0049075834,0.024396732,-0.024511192,-0.067304984,0.08712671,0.014054331,-0.035696834,-0.053954463,-0.03474973,0.051498245,0.019706747,0.013691493,0.07681879,-0.015407635,0.07405935,0.019778656,-1.3002965e-35,0.1008501,0.056639794,0.0050272513,0.017661488,0.037026625,-0.012457266,-0.078329585,-0.015996587,0.042264994,-0.016780844,-0.0760468,-0.028354643,0.008377577,0.031144856,0.029380225,0.13109767,-0.018911703,0.0079612695,0.102154896,-0.030944208,0.010645955,0.027282057,-0.009628778,0.02950841,0.01479511,0.05970025,-0.04010044,0.0751854,0.068738006,0.0012588466,-0.014720311,0.0016675536,-0.029522223,0.0539703,-0.00012477276,0.009855703,-0.06268415,-0.05389604,0.0036467684,0.018020995,0.09141661,0.0022242046,-0.021789825,0.006301645,0.0061945813,-0.07477565,-0.016080325,0.033592217,-0.022545096,0.06142536,0.059466414,-0.020325176,0.06611153,0.009285815,-0.0062907683,-0.02023373,-0.09075176,-0.07295746,0.015080814,0.07752572,0.009213525,-0.06307521,-0.022877619,0.028313093,-0.018264307,-0.003400117,-0.055892598,-0.037614375,-0.046695758,-0.019583287,-0.042012896,-0.04861743,0.037160944,0.059048157,-0.033271544,-0.07498797,-0.033734348,0.028737374,0.041575663,-0.06170338,-0.025180547,-0.0123117305,-0.0039940807,-0.021796033,-0.021390986,0.027587993,0.03799354,-0.1280962,-0.010235591,-0.058750395,-0.027170077,-0.05429227,-0.105675794,0.063659646,0.123696946,-2.350208e-33,0.07905159,-0.106841475,0.060982373,-0.03509954,-0.037988402,0.024584463,0.026600342,-0.066379525,-0.007951539,0.012454934,0.01006163,0.017654723,-0.02997364,-0.00636017,0.08232816,-0.053181328,0.022097113,0.09081936,-0.026753074,-0.081074424,0.05279402,0.020818764,0.038951863,0.02425321,0.07184401,-0.008733146,0.053582408,-0.0228866,0.0102938665,0.13185786,-0.0017888871,0.036161795,-0.024051735,-0.038159613,0.05499537,0.10278289,0.0077000246,-0.0061361697,-0.08498337,-0.018114557,0.02436005,0.049099285,0.0019776484,0.044776857,0.06379068,0.022982247,-0.049869698,-0.049832676,-0.030869327,-0.07598692,0.0146388225,-0.038850747,0.0017465913,0.015097236,0.035074677,0.09003778,0.010778088,0.049962528,0.02802891,-0.05692747,-0.0842117,0.033417065,-0.047615692,-0.039300784,0.05661712,-0.084548995,0.013379925,0.081868716,0.035453755,-0.006714714,-0.028933141,-0.048802916,0.08241961,0.11365163,-0.048193622,-0.0748732,-0.051300786,-0.06184736,0.038321145,-0.055714976,-0.035716265,0.028113097,-0.005000705,-0.026288103,-0.015534183,-0.05067008,0.06703722,0.12196384,-0.035456534,0.02960872,-0.0047441167,0.032167695,-0.09045672,0.006095918,0.00027873213,-4.0696033e-08,0.08448484,0.004376689,-0.012797457,-0.08891614,-0.02733207,-0.015332847,-0.028385019,0.07689429,0.0138516575,-0.045876376,-0.019749118,0.14620395,0.03903978,0.049315304,-0.032778677,0.048378628,-0.035544764,0.007052656,-0.025419706,-0.015540974,-0.09639212,-0.002962934,0.02230136,-0.027844852,-0.04151494,-0.12406778,0.008530044,0.10517066,-0.055849157,0.029814245,0.0038330862,-0.002446351,-0.04029781,-0.11921087,-0.0068088165,0.065435894,0.026805371,-0.07231611,0.049994383,-0.008182164,0.0046728905,-0.019042358,-0.00647001,0.01238439,0.024337834,-0.0054948335,-0.024142735,-0.0035099082,-0.04199826,0.03410047,-0.02257504,-0.033640865,-0.057548523,-0.1066709,-0.087969445,-0.08520755,-0.04996974,-0.084559515,0.06175344,-0.05180624,-0.020475008,0.06912235,0.099047616,-0.03902818 +2.6.1.119,"The enzyme participates in the biosynthesis of capsaicinoids in pungent cultivars of Capsicum sp. In vivo it has only been assayed in the reverse direction, where the preferred amino group acceptors were found to be pyruvate and oxaloacetate.",384,1.0,-0.01122026,-0.040646043,-0.11233135,0.00058038236,0.07569917,0.06854566,-0.047966063,0.04707906,0.036236443,-0.0003051328,0.11540196,-0.060436636,0.019801244,-0.0073071616,-0.06541714,-0.080749825,-0.09967459,0.027970627,0.012649454,-0.14493352,0.03448265,0.088662684,0.04396923,0.0110168215,0.0114434045,-0.029907877,0.03639313,-0.04142643,-0.06468386,-0.046925865,-0.016681487,-0.04871149,0.08222385,-0.07841711,-0.0034526037,0.14309509,-0.019448316,-0.0339087,0.11249368,-0.028005583,0.07336275,-0.025180459,-0.043861784,0.02473451,0.005393853,-0.03975148,0.007204946,-0.025632143,0.018153569,-0.035292707,0.007574911,0.028334713,0.018151037,0.023937361,-0.07807107,0.09732948,-0.009031655,-0.04657733,-0.02084928,0.027193727,-0.008100765,-0.07493007,-0.013837722,-0.0066175587,-0.008658678,-0.0387308,0.0440259,-0.04908814,0.022787232,-0.08210229,-0.052930534,-0.07441397,0.015020759,-0.028844591,0.0066874973,0.07175848,-0.036198758,0.03541731,-0.057984248,-0.008844095,-0.018491827,-0.054413754,-0.0007069804,0.06761334,-0.0002329997,0.01650521,-0.026644384,0.019296097,-0.0037264943,0.05404786,0.01243643,0.037897997,0.00084383454,-0.008451118,-0.062390722,0.061405767,0.040971886,-0.023775063,-0.009588477,-0.012693241,-0.035482697,-0.013436268,-0.09510128,-0.07504533,0.0031866892,0.0076698475,-0.052447826,-0.025692133,-0.038146067,-0.028869009,0.079852,0.01628676,-0.02030759,-0.0138837565,0.04185161,0.088839784,0.053043723,-0.02388109,-0.10410143,-0.036364213,-0.03781937,-0.059040133,0.014465108,-0.008537464,-0.02884511,0.02649793,-0.082773626,3.963593e-33,0.021443171,0.06730313,-0.014282818,-0.023138354,-0.046451263,0.0006240012,-0.05909943,0.030194174,0.008553919,-0.05451916,-0.061574813,-0.04296273,-0.020085087,-0.045766752,0.015914345,0.0026736013,-0.0010570096,0.048648823,0.019105364,-0.05854848,-0.030018568,0.028183788,-0.0106745595,0.028992388,-0.012940044,0.09926435,-0.02850489,-0.082490176,0.060364466,-0.009953377,0.020043321,-0.025656873,-0.07288232,0.03028861,0.04038435,-0.028334655,-0.03157214,-0.06005992,-0.050546553,0.04728207,-0.032474425,0.040566094,0.048892178,0.013040226,-0.0535681,-0.008072593,-0.044504564,0.08667947,0.09839631,0.10473163,0.005746341,-0.02262189,0.14005601,-0.00937902,0.012876984,0.019516848,0.008319968,0.02720804,0.037115574,0.029122386,0.025926573,-0.015580735,-0.035271548,0.056265384,-0.045695037,0.08631662,-0.10781158,-0.039462708,0.044027794,0.09971895,-0.05413495,-0.040374022,-0.048499644,0.0897095,0.043000385,-0.03467213,-0.019551445,0.05001744,0.011763598,0.009096088,0.023686148,0.024320347,-0.040139433,0.05692701,-0.007827937,0.005419321,-0.08656912,-0.0034655055,0.1203987,0.049059283,0.042820666,0.029498016,-0.026117561,0.03493355,-0.004036755,-4.1015705e-33,0.06125768,-0.081770286,-0.05775378,-0.0058505773,-0.018581169,0.03433898,-0.058476258,-0.052504253,-0.012195543,-0.062573366,-0.008716836,0.018807584,-0.03349775,-0.033687178,-0.05698442,0.08357186,0.11799223,0.1306122,-0.057567973,-0.030352239,-0.053144734,0.064694874,-0.004079256,-0.008506308,0.035393048,0.008089304,-0.0059468523,0.04055916,0.0019505004,0.024249127,0.014471055,0.050813332,-0.05595271,0.015002753,0.033357315,0.031590078,-0.009118093,-0.0067642406,0.06994494,0.11080741,-0.021785544,0.044136837,0.08266604,0.080350734,0.061322853,-0.020442968,-0.021817466,0.0067851734,-0.07245401,0.047426257,0.035971906,0.02458566,-0.0053903405,-0.03029417,0.034693576,0.005774723,0.030128496,-0.023573961,0.0077814553,-0.055542085,-0.0103995195,-0.109282084,0.008433102,0.042828955,-0.025701286,0.025575232,-0.008901902,0.03168595,0.008383993,0.0036360295,0.08185476,-0.10564633,0.017070102,0.026066834,-0.030392429,0.020102296,-0.051362514,-0.0058851982,0.02844368,-0.011783575,-0.041409507,0.03394982,-0.0028856269,-0.08160659,-0.050660763,-0.040497333,0.017294249,0.046794657,0.023930572,0.025699196,-0.004306697,-0.025655651,-0.033845875,0.066614494,0.14188845,-3.668581e-08,0.025077134,-0.048580617,0.06388191,0.040223237,-0.005177481,0.04326534,-0.00107176,-0.039054807,0.017729098,-0.069912195,-0.06057189,0.072323985,0.0013642311,0.012331993,-0.021279804,0.08186386,0.061395757,0.0949435,-0.06620195,0.070392534,-0.08960696,0.0077569773,-0.10223199,-0.017638974,-0.0025402529,-0.0390147,-0.028415477,0.048726775,0.025303131,-0.042727847,0.09462269,-0.024088457,-0.04097474,-0.08662894,-0.023277393,0.06278219,0.015558037,-0.05865865,0.024795504,0.031728845,-0.037351925,-0.051050257,-0.054290917,0.04510517,-0.07552984,0.04588648,-0.050832007,0.013841547,-0.029221589,0.054151915,0.0019338066,-0.050603084,0.01901164,-0.04302611,-0.09629908,0.036561243,0.12384272,-0.025168048,-0.034000017,-0.06656045,-0.041286137,0.08495026,0.15881135,-0.072478704 +2.7.1.231,"The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. Stereospecificity of the product, 3-oxoisoapionate 4-phosphate, has not been determined.",384,1.0,-0.013034925,-0.067851566,-0.0140072005,-0.10342107,-0.03129672,-0.030554399,-0.088948525,0.033941127,0.04963791,0.06512857,-0.009767705,-0.017145056,-0.013151298,0.07466069,-0.04413342,0.06823906,-0.026942953,0.058493257,-0.023831733,0.00860449,0.08560708,0.02515172,-0.008759979,-0.04672958,0.07351472,0.051802892,0.052815612,0.005031122,-0.069189414,-0.066731445,-0.009094028,-0.009107465,0.060704283,-0.062126122,0.08393553,0.06348974,0.010087802,-0.021948969,0.11648273,0.0020348993,-0.024953313,0.010106558,-0.0036583696,-0.012808784,-0.06269021,0.0361791,-0.08936837,0.00042067323,0.022408236,-0.026697474,-0.050467893,-0.043925244,-0.035196066,-0.0010565969,0.035992973,-0.06706892,0.04052142,0.04741602,-0.05522028,0.034001056,0.08953323,0.013366274,0.079537526,0.022030551,0.047165982,-0.009897267,0.028603312,-0.06817422,-0.017600112,-0.03454199,-0.058336414,-0.08235008,-0.0037102452,0.009207862,0.013121254,0.032218806,0.02747259,-0.120977715,-0.016358731,-0.07742569,0.07858385,0.04448303,-0.010547975,0.08683629,-0.0016308851,0.025614984,-0.0013424277,-0.07996591,0.034306075,0.0024575416,-0.00041117406,-0.00076476263,-0.02433859,-0.053065818,-0.01196888,0.0070594945,-0.023060754,0.035577748,0.027380176,-0.0026725458,-0.04043006,0.06507846,-0.09510426,-0.112932086,-0.032581985,-0.021108449,-0.023987034,0.059150822,-0.010535939,-0.0016622238,0.02342452,0.012683763,0.013079573,0.05931794,-0.058761396,0.10291991,0.01720243,-0.022619484,-0.10698967,-0.009557326,0.0031545463,-0.07756558,0.05711965,0.031597175,-0.023918154,0.018323176,-0.0038390798,-1.3340742e-33,0.06877008,-0.0033247904,-0.031177953,-0.032890584,0.033484735,-0.058603212,-0.05457982,0.0123213,-0.0701976,-0.048402887,-0.07481993,-0.060326643,0.025554474,-0.012398457,-0.019843807,0.03377675,-0.006790658,0.047314353,-0.015165044,0.01050605,0.043588825,0.060336117,-0.03985067,0.034068383,0.0011120295,0.074910484,0.006534752,0.062302962,0.026557159,-0.0067999014,-0.00056516274,-0.115896605,-0.11091241,-0.008886586,0.03644234,-0.054365642,-0.07363056,0.0067849103,-0.018081376,0.037006192,-0.0035705785,0.057007037,0.0025241934,0.013203194,0.04913632,-0.032791644,0.008863795,0.105072916,0.0137698185,0.03450927,0.024162024,-0.021071512,0.07672016,-0.01084718,-0.037904695,-0.005771552,-0.018483507,-0.058730684,0.04013517,-0.007150398,0.012764528,0.026718177,-0.034988374,0.0070727263,0.031551696,-0.028617488,-0.04871867,-0.044443555,0.04322261,0.060066678,0.006000163,-0.052833978,-0.026951157,0.011969298,0.0016471305,-0.08681151,0.034373987,0.012182789,0.044359192,-0.051057503,0.017948741,0.017658394,-0.0067807664,-0.04561275,-0.02593005,0.035037395,-0.017886184,-0.0830809,-0.050717063,0.05967886,0.03731619,-0.06555271,-0.16594128,0.0026264004,-0.009922002,-6.703735e-34,0.043760028,-0.018635694,0.047344945,-0.05249269,-0.0946794,0.07156168,-0.0024705818,0.13220611,-0.019169867,-0.013051524,0.05877029,-0.0027069484,-0.003908396,-0.021002457,0.0107368305,0.0400003,-0.026832368,0.0148095265,-0.030760283,0.027170282,0.004097877,0.09430226,-0.006388032,-0.00089971867,0.025203636,0.0416053,-0.028190097,0.03199814,0.051537294,0.041897997,0.062563024,0.029630395,-0.02259499,0.009743656,-0.024773384,0.0809272,-0.030702757,-0.014549021,-0.042087074,0.05082074,-0.058795474,0.021155437,-0.016478054,0.022578025,0.06416858,0.041422974,-0.062034436,0.07033182,0.009268507,-0.025328392,0.064306654,-0.006759106,0.048668783,-0.014901744,0.012886559,0.062335677,0.053525474,0.05893185,-0.061959296,-0.0018492113,0.018985875,-0.100608274,0.09092688,0.026757523,0.028703656,0.11971499,0.024745708,0.06963559,0.030096093,-0.016637662,0.066888735,0.015164766,-0.038804676,-0.037982155,-0.049644522,-0.06329811,-0.15118016,0.040248696,0.03269372,0.05669078,-0.06045301,0.020936005,0.010986856,-0.024907952,-0.04038424,-0.11539297,0.05784274,0.094302535,-0.073977806,0.08062457,-0.0003549534,-0.01056334,-0.09870477,0.02710699,0.107475355,-3.0741084e-08,0.11525749,-0.016525313,0.04815136,-0.01350091,-0.0017785364,-0.0063114217,-0.011007526,0.05221429,0.07519608,-0.010968346,-0.044586398,0.06350023,-0.07833322,-0.013315649,0.062859386,0.0038097939,-0.040652398,0.003987572,-0.06313268,0.044297874,-0.04002786,-0.0004896788,-0.082617566,-0.05296036,-0.014615092,-0.011502059,0.0844872,-0.011745793,-0.037453737,-0.017999822,0.006245587,0.031433057,0.000296424,-0.13275012,-0.09968669,0.015285709,-0.06782894,-0.066556245,0.0039848057,0.06899243,-0.030627947,0.002025601,-0.075259335,0.06668047,0.042077262,0.02758488,-0.009416756,0.017800894,-0.03835425,0.011235079,0.014020568,-0.02421661,-0.02692801,-0.08670017,-0.17525388,0.06890348,-0.011022638,-0.03961407,-0.032985497,-0.053233102,0.035527654,0.004428688,0.15992068,-0.037978783 +2.7.4.33,"The enzyme, characterized from the bacteria Acinetobacter johnsonii and Pseudomonas aeruginosa, transfers a phosphate group from polyphosphates to nucleotide monophosphates. The highest activity is achieved with AMP, but the enzyme can also phosphorylate GMP, dAMP, dGMP, IMP, and XMP. The reverse reactions were not detected.",384,0.99999994,-0.12858216,-0.073151276,-0.051817212,-0.04107363,-0.023432083,0.023977384,0.00843328,0.061637577,-0.02554613,0.08582217,0.026887927,-0.036386244,0.0024692458,0.06311067,-0.07866675,0.064575605,0.03358864,0.052623022,0.022411428,-0.018702695,0.102490954,0.040214125,-0.07692163,-0.07115033,0.06376035,0.042997696,0.0093697645,-0.005061195,-0.037772648,-0.043189935,-0.07584045,-0.09719003,0.09791091,-0.08931194,0.054444056,0.15323052,-0.06263526,-0.104431465,0.11696295,0.016637836,0.047808357,0.024903921,0.043961473,-0.056857962,-0.020022389,-0.0068162633,0.012839258,0.05856136,0.045311775,-0.0274795,-0.024017198,-0.032581106,-0.0064962786,0.031930085,-0.0537284,0.0060889907,-0.04101522,-0.03461991,-0.046487544,-0.031096518,-0.022843143,0.0032254034,0.034074053,0.045842413,0.06357309,-0.03665173,0.035317525,-0.039629307,0.028733907,-0.013071884,-0.042727653,-0.01676108,0.046916846,-0.022176933,0.038548015,-0.039853014,0.005881314,0.0054081725,0.04371005,-0.0639627,0.010811339,-0.07241568,-0.015075797,0.051721897,0.008283539,-0.010008729,0.009099988,0.053394202,0.01663467,0.048216112,-0.0037705044,0.008777181,0.057705376,-0.085451506,-0.036890335,0.012050445,-0.022784904,0.012890267,0.031910233,-0.032631278,-0.009684779,0.12389533,-0.007092023,-0.08475505,-0.012816889,-0.048859175,-0.041867178,0.06417819,0.018772347,0.02002822,-0.042547878,0.024901824,0.014276979,-0.033689335,-0.005832964,0.049087856,0.03618067,-0.049256172,-0.10288701,0.016094277,0.0085285185,-0.1335455,-0.01484619,0.09143206,-0.030377975,0.09414137,-0.09723648,3.5938242e-33,0.025509877,0.03887264,0.0364964,-0.12271746,0.032118354,0.010654574,-0.06926752,0.028547348,-0.041780394,-0.042881384,-0.056241907,-0.028542794,0.076156005,0.020704858,-0.064488314,-0.024781423,-0.032321777,0.054323327,0.06863552,-0.014720635,0.05321249,0.06888677,-0.019716857,0.063858815,0.04780718,0.073655695,-8.202591e-05,0.017719636,-0.020903947,-0.004033684,0.046826236,-0.070549816,-0.12716359,-0.014641057,0.041346982,-0.050658524,-0.037606034,-0.037420925,0.026401658,0.052487444,-0.01891166,0.014868193,-0.024687445,-0.0041227634,0.07004055,-0.04651603,-0.079809,0.08720417,0.017608894,0.089751676,0.014629209,-0.042540204,0.06497629,-0.049134687,-0.05683405,0.024851758,-0.05073105,0.005293065,0.035940867,0.050651766,0.051211827,0.07300819,-0.05233343,0.0036219854,-0.07159559,-0.0063020764,-0.02428613,-0.07604017,0.07012488,0.12033157,-0.032999154,-0.04257594,-0.00078005204,0.04499896,-0.0011258678,-0.032319844,-0.0135014905,0.037659235,0.00561134,0.021729147,-0.002088716,-0.024563432,0.043082673,-0.072019525,-0.029591378,-0.033021986,-0.0052520526,-0.025411937,-0.029010199,-0.00065032335,0.05678452,-0.020314902,-0.06894144,0.039652273,-0.022871748,-4.8793283e-33,0.14405404,-0.040848896,0.020968243,-0.015913107,-0.0772986,-0.0035216252,0.012305261,0.023886308,0.044832196,0.008405025,0.06908579,0.0062412294,0.03425395,-0.022594724,0.011210029,0.037932124,0.040354133,0.064202905,-0.021662239,-0.005915301,-0.02112285,0.06884278,0.076960884,0.028382117,0.05552157,-0.028361494,-0.05813528,0.076285265,-0.016370367,0.077647865,-0.003833316,0.06181228,-0.050814826,-0.011950484,-0.054498605,0.032372296,-0.03354927,0.016309893,0.03359729,0.021483086,0.110772826,0.053962804,0.028573858,0.07646607,-0.03440841,0.052794974,-0.066528,-0.023783604,-0.021631248,-0.10681026,-0.003940927,0.009923632,0.010600045,-0.0057843034,0.026650595,0.09268983,0.009166655,0.043971393,-0.04843199,-0.041978583,-0.00089233386,-0.11351664,0.039845012,-0.03265443,0.057283722,0.10230139,0.03312835,0.023275897,0.010880059,-0.046494715,0.015763752,0.047487985,0.02973026,-0.014684675,-0.06882595,0.0060941796,-0.097157694,-0.026721774,-0.040186204,-0.052204892,0.023460362,0.010835205,-0.040441595,-0.04840796,-0.009726284,-0.011351644,0.01337179,0.082167536,-0.010565908,0.009843717,-0.055625353,-0.014503268,0.023226373,0.014252683,0.0572172,-4.233493e-08,0.030835757,-0.0013703526,0.074521296,-0.029730625,0.033149943,0.08825058,-0.05582047,-0.013233372,0.051402494,-0.03721644,-0.03394446,0.051676124,-0.0036931124,0.028333811,0.07313259,-0.028718023,-0.0872222,0.0132192075,-0.036506224,-0.03525864,-0.06723149,-0.0104312645,-0.096444905,0.10865026,0.049028616,-0.0033939078,0.05273311,-0.045503143,-0.023654737,-0.019497972,-0.07485861,-0.028677583,-0.060639087,-0.037293512,-0.06811683,0.019013321,-0.016971515,-0.02297129,-0.05832039,0.0022075,-0.018530453,-0.025131466,-0.09861719,0.047319274,-0.017045116,0.037853178,0.012146488,-0.00023454937,-0.06806258,-0.03373804,0.10635734,-0.057042424,-0.020802738,-0.07335246,-0.07964059,0.0028041068,-0.0631586,-0.0809898,-0.067752235,0.033456475,0.032069527,0.007857337,0.13488564,-0.05368362 +2.7.7.104,"The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. The enzyme also is active as EC 5.4.2.9 phosphoenolpyruvate mutase.",384,1.0,-0.033203177,-0.008458042,-0.15423967,-0.03764382,0.043010987,0.05307926,-0.073965,0.07711365,0.053706322,-0.0052395402,0.0024125774,-0.019636415,0.04314844,0.044129007,-0.010434332,-0.0074548,-0.07584722,-0.032617386,0.0155626265,-0.035266865,0.1030862,0.084360905,0.018705767,-0.0015517913,0.06799835,-0.06744847,0.023153005,0.03231528,-0.07344349,-0.05128187,0.0626371,-0.022948576,0.08770929,-0.03532864,0.0992275,0.11995635,-0.051517393,-0.07021557,0.13233025,0.031484783,-0.046810374,-0.03222148,0.00220083,0.0015647247,-0.03775389,0.06344436,0.028026277,0.08743372,0.0295854,-0.0133687025,-0.071361646,-0.033709116,-0.020049553,0.01420684,0.086392224,0.081267744,-0.009254873,-0.0595129,-0.041998148,-0.026446573,0.05763773,-0.021513654,0.034907408,0.03622526,-0.069254935,-0.009994907,0.022836747,-0.09167821,0.029317176,-0.05785951,-0.08221785,-0.020237768,0.029306563,-0.0043365504,0.011491613,-0.01989993,-0.0013727129,-0.0013621127,-0.010960714,-0.036749657,0.039600644,-0.041107986,0.012168843,0.026127227,0.04280236,-0.02138004,0.03271191,-0.025542108,0.044286963,0.07690774,0.03739457,-0.0376311,-0.030863883,-0.057333842,-0.051446795,0.013118935,-0.055024732,0.018311488,0.012821771,-0.010372588,-0.004924888,0.02549438,-0.0016039445,-0.0272319,-0.011326357,0.024848957,0.012743112,0.06950793,-0.011050486,-0.040536642,0.010659405,0.00043876152,0.00481045,-0.036361344,-0.014144145,0.05001967,0.09761013,-0.10010017,-0.09475131,0.00052872044,0.013580738,0.031239398,0.024922103,0.054885652,-0.06311878,0.036948394,-0.14506367,3.6067932e-33,0.0005848788,0.053383555,0.0059378734,-0.06691127,0.04558881,-0.004651997,-0.0776132,0.010580073,-0.02168152,-0.08165957,-0.079544626,-0.06686264,0.03587883,-0.010963523,-0.018961536,-0.04372908,0.018657425,0.039726924,0.041416258,-4.2293766e-05,0.078998394,0.0010389446,-0.0014958279,0.01878312,0.048765033,0.07366947,-0.040052544,0.04306205,0.08955714,-0.01048146,0.006719793,-0.06816516,-0.06165345,-0.045171455,0.07180471,-0.06624105,-0.0801492,-0.036393616,0.01273512,0.035769396,-0.0128341885,0.030582117,0.001569767,-0.022528583,0.051496882,-0.029733872,-0.0804256,0.07560558,0.12378902,0.0810173,0.03804664,-0.05184992,0.107284226,-0.052146815,-0.043025527,-0.0049158377,-0.01769711,0.016601533,0.020427722,0.033108473,-0.0072707576,0.04823759,-0.0063928114,-0.01689932,0.0068675443,0.037483655,-0.00807388,-0.020124216,-0.018767372,0.082861304,-0.042101104,0.02321616,0.029583065,-0.03795087,0.051208634,-0.017002493,-0.08145108,-0.08429207,-0.01770409,-0.023574246,0.033141218,-0.035826396,-0.013202457,-0.040261723,-0.04665276,0.011395982,-0.04237958,-0.045689724,0.034535717,0.09273534,-0.010806464,-0.08648655,-0.044866975,0.00916314,0.027764566,-4.1865577e-33,0.090535946,-0.049626343,0.089239866,-0.0661105,-0.025229469,0.094550416,-0.022696445,0.006973251,0.007978422,-0.013984618,0.030639442,-0.03257839,-0.01682248,-0.08095449,-0.015087127,0.008325177,0.0118140355,0.10785633,-0.010373042,0.058218803,0.023632769,0.048081513,0.019145157,0.003446246,0.061896898,0.034842193,-0.02923286,0.09273045,0.030396191,0.02919206,-0.041948877,-0.04133338,-0.07464371,-0.05932198,-0.05935286,0.036237955,-0.09636889,0.021846805,0.0697926,-0.017637646,0.060038682,0.068985686,0.037946444,0.062327225,-0.02484934,0.05283668,-0.08387883,0.03957264,0.004102028,-0.03898752,-0.029242674,0.032908916,-0.028507683,0.014825423,-0.027624587,0.024320185,0.01060079,0.0637473,-0.059281852,-0.04052518,-0.03067346,-0.09954853,-0.0038861043,0.0010260982,0.11164962,0.014875148,-0.02724275,0.08370441,0.06408183,0.049373493,0.057169933,0.014733896,-0.0504241,0.02774257,0.011932418,0.033220302,-0.106699884,-0.064169794,0.0067745396,0.07813008,0.04939226,0.0014270952,0.018375311,-0.054609757,-0.040480893,-0.075937115,0.047451667,0.018616851,0.033391446,0.0121153,-0.012824351,0.024224078,-0.0015299697,-0.000110576286,0.045922413,-3.2152585e-08,0.04245186,-0.02262123,0.023013502,-0.043259427,0.053288512,-0.047552723,-0.007508402,-0.052153688,0.017089613,0.00047790186,-0.027230486,0.051522445,0.02623311,-0.035398237,0.025574325,-0.039976053,-0.06897022,0.020234333,0.024072774,0.010634449,-0.060671557,-0.013707043,-0.14279455,0.07520792,0.05159413,-0.040560216,-0.0011265527,-0.005584878,0.00044217164,0.03355785,0.055085197,-0.006911006,-0.046501495,-0.019683855,-0.12602001,-0.0022031679,-0.11895161,-0.030051347,-0.042528305,0.04150699,0.052498545,-0.05858192,-0.020946333,0.04949141,-0.09005073,0.04937827,0.021081807,-0.030354641,-0.04397845,-0.021527445,0.0538637,0.008418209,-0.028232979,-0.011624582,-0.1362329,0.012271938,0.00877565,-0.059717912,-0.04736631,-0.064476594,0.0027280434,-0.007798596,0.19948342,-0.039067492 +3.2.1.214,"The enzyme, characterized from the bacterium Parabacteroides distasonis, specifically hydrolyses (1->2)-beta-D-glucooligosaccharides to sophorose. The best substrates are the tetra- and pentasaccharides. The enzyme is not able to cleave the trisaccharide, and activity with longer linear (1->2)-beta-D-glucans is quite low. This enzyme acts in exo mode and is not able to hydrolyse cyclic (1->2)-beta-D-glucans.",384,0.99999994,-0.048781473,-0.11611367,-0.09205089,-0.032983564,-0.017192775,0.007054813,-0.074381545,0.06682611,0.04179243,0.03641654,0.0445109,0.0027568983,-0.046409108,0.11184453,-0.07938917,-0.03265179,-0.000504704,-0.042984724,0.016612656,-0.012510538,0.11976767,-0.022817755,-0.08559034,-0.0058326973,0.078343414,0.012693728,-0.02327801,-0.014758807,-0.03168381,-0.077016115,-0.048040256,-0.058247916,0.010916703,-0.057878263,0.06732438,0.09535456,-0.0129743535,-0.03384348,0.09746581,0.01780887,0.0031384937,-0.026611289,-0.0072797597,-0.05328186,-0.026507327,-0.03517915,0.002009782,0.101852976,0.06550429,0.011225081,-0.034179177,-0.07478829,-0.05482482,0.067115,0.010587149,-0.01811858,-0.059683397,0.042293016,0.004272324,0.021250175,0.0622872,0.02158788,0.016424488,0.03236645,-0.031897325,-0.070083246,0.020866415,-0.073518515,-0.036883544,-0.004664696,-0.0335126,-0.011634452,0.02428828,0.048316155,0.002835551,0.03388442,-0.008488516,-0.05247919,0.0030273395,-0.03847322,0.12343596,0.0012184113,0.044694472,0.096677564,0.024190955,-0.056640666,-0.02404497,-0.0072572245,0.09970942,0.03788825,0.049686868,-0.006709913,-0.0032961608,-0.032426167,-0.069117844,-0.007838841,0.0034680364,0.0035595621,0.029464452,-0.041488163,-0.032964695,-0.026703147,0.050370038,-0.0862072,-0.020079741,0.040296365,0.0002367891,0.063644946,0.09569737,-0.009071451,-0.007795914,0.052698683,-0.003262731,0.007467591,-0.12641054,0.05092852,0.04891606,-0.07472133,-0.09823325,-0.030985348,-0.0054950584,-0.0714684,0.08780887,0.08012212,-0.0145911835,0.12955336,-0.06422128,1.1615432e-33,0.07238371,-0.023544932,0.05472186,-0.04993249,-0.038080372,0.016094651,-0.04978196,-0.007706046,-0.050634313,-0.05301213,-0.0601111,-0.025840648,0.0035811,0.10475479,0.046921745,0.05971036,0.016362835,-0.03679941,0.034707077,0.04449044,0.037300233,0.051555473,-0.057822905,-0.059874475,0.1113552,0.050948102,-0.025821941,0.04029113,0.055551514,0.011217603,0.059221845,-0.08200419,-0.09900835,0.037543368,0.1043128,0.02536876,-0.06850969,0.0063451133,0.010506267,0.0036452548,-0.0034140104,-0.0020324187,0.01748948,-0.028895758,0.023357635,-0.041740153,0.06470092,0.056807723,-0.045817193,0.057717785,0.046972144,0.015365745,-0.0026713407,0.009086814,-0.042929232,0.037348464,-0.0028704503,-0.021326596,0.05536895,0.070022106,0.029227985,0.06903148,-0.019856209,-0.010049953,-0.008606427,-0.030578544,-0.06703332,-0.028874487,-0.006811917,0.02985928,-0.094357885,-0.028584085,0.04238361,-0.0067725047,-0.033554263,-0.06376476,0.012860085,-0.012995481,0.071820654,-0.06951554,0.048090085,-0.062864,0.017899517,-0.005229036,-0.10582703,0.06865657,-0.017906226,-0.008652919,-0.031099843,0.052725706,0.0041092676,-0.042595018,-0.05758683,0.044527452,-0.0040756213,-2.533242e-33,0.13148975,-0.118985444,0.042020794,-0.040860873,-0.023305735,0.057781618,0.012223587,-0.0028838045,0.004154528,0.005124826,0.06873727,0.033347875,-0.041721605,-0.007254328,-0.016191695,-0.008529515,-0.009114664,-0.0046451217,-0.043700017,-0.10419705,-0.02689663,0.10051018,0.046915866,0.0047086594,-0.0010271437,0.011578729,-0.008235278,0.043105822,-0.013182738,0.1058186,-0.06036035,0.008791144,-0.012388538,-0.05862861,-0.028114619,0.0675491,-0.08998797,-0.04068786,0.05466024,0.005810059,0.017345617,0.028690707,0.014046539,0.052164655,0.024071852,0.118558615,-0.049952675,-0.02483159,0.018856695,0.019394202,0.030961987,-0.03679429,0.0027793818,0.04263596,0.048270248,0.006665839,0.010747509,-0.0022264116,-0.08703789,-0.06775159,-0.030149657,-0.05662126,0.015338723,-0.07953072,0.09771294,0.04882973,-0.03274816,0.02957827,0.013739645,0.0016046587,0.021136757,-0.04586272,-0.062682,0.0049519385,-0.031985518,-0.034031022,-0.11831728,-0.070369124,0.0065658977,-0.06860132,0.0033836898,0.010479459,-0.022975784,-0.030024828,0.06899873,0.00890322,0.008320985,0.112719215,0.012278871,0.10232946,-0.0023214067,-0.029441906,0.00028818595,0.08298731,0.1082871,-4.6160245e-08,-0.0066786697,-0.035362564,-0.0094918655,-0.044633847,-0.0014844498,0.034111127,0.02497565,0.014646731,0.061647117,-0.0346018,-0.027014527,0.07685791,-0.016517822,0.02521513,0.029389674,0.040310185,-0.07102664,-0.0368914,-0.01824194,0.0038277553,-0.067366846,-0.059132114,-0.15164286,0.034743432,-0.031030104,-0.03350619,0.083895266,0.039378155,-0.0539711,-0.0015852345,-0.02603872,0.010698736,-0.088323824,-0.036770433,-0.07179804,-0.013976408,-0.08075454,0.032666113,-0.0042958744,0.017009335,0.022260003,0.043493547,-0.05314294,0.041798282,-0.00833089,-0.00639509,0.026264902,0.057880033,-0.0045951633,0.041776136,0.040702417,-0.05369572,-0.060853604,-0.015163898,-0.091060735,-0.01563104,-0.007942926,-0.014524307,-0.05044565,0.0048101,0.021822946,-0.0058551133,0.15531805,0.024568109 +4.1.1.120,"The enzyme, characterized from several bacterial species, is involved in the degradation of D-apionate. Stereospecificity of 3-oxoisoapionate has not been determined.",384,0.99999994,0.00034934978,-0.075258866,-0.04691222,-0.069828965,-0.027202494,-0.022127738,-0.118665345,0.013064423,0.050238606,0.02970653,0.0013080427,-0.048795205,-0.015958967,0.044731013,-0.02942479,0.075619176,-0.04890029,0.037950076,-0.010322514,0.017220784,0.068165615,0.0039281216,0.007114981,-0.039678644,0.058663238,0.042366628,0.017971875,0.024313401,-0.09919926,-0.07892993,0.0056346334,0.0025371872,0.05684075,-0.03925198,0.057262994,0.036420766,-0.0056061163,-0.013707457,0.13343742,0.01987834,-0.04018197,0.011916337,-0.01836125,0.00065134774,-0.061619565,0.022351824,-0.11280128,-0.01112974,0.010682868,-0.02056773,-0.039292708,-0.06784108,-0.047751836,0.01748321,0.029771881,-0.049453422,0.04848552,0.046149697,-0.041635312,0.048924923,0.078973986,0.041051622,0.07557725,0.032515243,0.022631189,-0.011500785,0.0037492455,-0.08739635,-0.00566598,-0.02921925,-0.060074788,-0.08894652,-0.0029663618,0.011721758,-0.00095022406,0.049452987,0.045647632,-0.1075973,-0.04280104,-0.08411963,0.04485276,0.044851903,-0.016616387,0.103447884,-0.015290078,0.020090673,0.003500791,-0.07777059,0.009698034,0.02255321,0.0059144343,0.008675981,-0.028148102,-0.02341991,-0.011605994,0.0084446,0.0071748067,0.053153846,0.009566774,-0.015134307,-0.031550508,0.07309723,-0.07304186,-0.104259096,-0.040441647,-0.018534195,-0.028935988,0.033200737,-0.014809183,-0.018501377,0.02215697,-0.018324824,0.033945706,0.036861144,-0.045273256,0.11579212,0.011551941,-0.018421233,-0.093633875,-0.013524238,-0.0013011409,-0.07030788,0.049727857,0.0058306847,-0.014068702,0.017869987,-0.010836809,-7.0226457e-34,0.075589724,-0.02156334,-0.041881807,-0.03474186,0.037293434,-0.061780673,-0.06561951,0.034645963,-0.048467953,-0.038222283,-0.0806204,-0.05169704,0.009265278,-0.013613379,-0.014366969,0.052106246,-0.008976415,0.014910521,-0.042181578,0.009430375,0.022904294,0.04307204,-0.033411674,0.007593467,-0.0032995124,0.08813848,0.018618867,0.042069793,0.037072476,-0.004862336,0.024183307,-0.1410458,-0.107860826,0.023924626,0.041159183,-0.019453706,-0.049384017,0.01041711,-0.037933923,0.03722332,0.001718226,0.063723385,0.019526223,0.0040564863,0.07287672,-0.00980865,0.002750752,0.116839275,0.022503903,0.03252151,0.0044085737,-0.015781702,0.08721566,0.018212328,-0.018720223,0.016230794,-0.02500455,-0.013470004,0.03453658,-0.021623785,0.00047560432,0.021854525,-0.015381108,0.0077671735,0.026848925,0.014778662,-0.0794767,-0.021518381,0.029266037,0.03971866,-0.010834189,-0.049611688,-0.038715918,0.01474284,0.024962379,-0.08041062,0.015724558,0.0071105747,0.044591784,-0.06199914,0.016187055,0.011093541,-0.009152215,-0.038358375,-0.015278554,0.053462025,-0.016644716,-0.05172757,-0.053714357,0.07108221,0.047900274,-0.047725286,-0.13464803,-0.0037054406,0.0027047293,-1.2748631e-33,0.03947523,-0.041475836,0.028644959,-0.07920396,-0.08229574,0.100210786,-0.054413736,0.15046273,-0.0503667,-0.022731612,0.038760785,0.019905679,-0.014164676,-0.05838904,0.0015187039,-0.008390764,-0.026064474,0.033287503,-0.0139226485,0.031973228,-0.00065011985,0.08434935,-0.021164559,-0.015493522,0.02847925,0.05736703,-0.03965547,0.019034501,0.043796033,0.03997188,0.053385373,0.025661264,0.003414862,-0.0035522769,-0.004232312,0.08306293,-0.031443708,-0.02637093,-0.012849248,0.08192503,-0.09708513,0.0005217919,-0.03155178,0.0027723012,0.09345335,0.06558837,-0.10223038,0.054033954,0.0115768155,-0.0062144427,0.064863674,-0.021104291,0.026374828,-0.025046533,0.042957474,0.04474607,0.045728162,0.041924767,-0.014015173,-0.021832522,0.019598434,-0.08313573,0.07265745,0.026374346,-0.00061255996,0.12820923,0.027818909,0.08650441,0.020456664,0.008379208,0.06826815,0.01710018,-0.053973425,-0.036663063,-0.014544768,-0.096151866,-0.13077874,0.030983822,0.030399974,0.062811606,-0.043767706,0.024696466,0.047571592,-0.01855506,-0.032394636,-0.10475776,0.05796198,0.08064356,-0.09377499,0.0762327,0.023655545,-0.0043977387,-0.09267203,0.02280964,0.105594255,-2.8455942e-08,0.1319865,-0.008846139,0.056222018,-0.0029689302,0.013306603,-0.0057878764,-0.016890192,0.06334636,0.07164795,0.0010179646,-0.025586456,0.06719104,-0.044193845,0.0045142374,0.050723255,-0.031068772,0.013773646,0.016052961,-0.055920724,0.07375797,-0.05240488,0.0048963246,-0.07463555,-0.056798253,0.01760281,-0.024492828,0.0745377,-0.029902749,-0.03948451,-0.0030387084,-0.015506071,0.02881254,0.022815472,-0.13626793,-0.10812476,0.03028312,-0.06655847,-0.085539326,0.0011727884,0.036712706,-0.027772052,-0.0035589035,-0.07203277,0.04976711,0.068863645,-0.0074593313,0.0216852,-0.010521132,-0.042075932,-0.011325329,0.0057588858,-0.041386195,0.022402879,-0.08074145,-0.1868216,0.060582317,-0.010079823,-0.040453758,-0.050067704,-0.057763822,0.031229591,-0.003095602,0.1572388,-0.032473966 +4.1.1.121,"The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. It belongs to the RuBisCO-like-protein (RLP) superfamily. Stereospecificity of 3-oxoisoapionate 4-phosphate has not been determined.",384,1.0,-0.06540444,-0.09189924,-0.08075605,-0.076275945,-0.038373243,0.004333375,-0.09856262,0.0077641197,0.02621695,0.045017894,0.0041525206,0.011224586,-0.023986373,0.09387506,-0.023870826,0.05769309,-0.04281941,0.05528891,-0.024040107,-0.015416051,0.109714456,0.009303953,-0.0105721755,-0.045960143,0.060631666,0.024736209,0.055154976,-0.007874844,-0.07887593,-0.08055386,0.00954082,-0.013544723,0.049891233,-0.083943345,0.091342464,0.07144666,-0.015223461,-0.035587538,0.13515836,-0.0108718,-0.032329887,0.025436796,0.021110369,-0.007414044,-0.06532487,0.04145876,-0.060865846,0.02619652,0.09455863,-0.039343372,-0.05740204,-0.056825582,-0.047504928,0.008473203,0.060710195,-0.060565215,0.037601646,0.020833397,-0.03506799,0.04072175,0.08806715,0.00077356485,0.06448675,0.036221735,0.021402478,-0.01081801,-0.002499378,-0.049895015,-0.0035104756,-0.027326498,-0.056022026,-0.07448565,-0.01412646,0.03696645,0.034915917,0.038042262,0.015831714,-0.06817971,-0.04196727,-0.054086037,0.04131504,0.04281006,0.0018503844,0.08545538,0.0010131876,0.028450297,0.044459242,-0.08368706,0.0116543835,0.015108316,0.003045568,0.02298674,-0.024958063,-0.06568771,0.0017020219,0.0058743525,-0.013171532,0.01869291,-0.009766899,-0.021640586,-0.023064593,0.07748488,-0.05795088,-0.09984207,-0.029466787,-0.01488746,-0.055012826,0.06674259,-0.013018431,-0.0048120413,0.043329254,0.042850234,-0.0035733364,0.036290806,-0.05333011,0.07589552,0.0187884,-0.03773586,-0.09714765,-0.011499671,0.009557168,-0.07343195,0.0204772,0.041627415,-0.006612599,-0.0057687857,-0.06368632,-1.4443273e-33,0.093994215,0.011886705,-0.05834834,-0.021148898,0.0027279686,-0.037975408,-0.07661361,0.018652217,-0.07368956,-0.03536166,-0.04127808,-0.047437184,0.045542184,-0.0054946514,-0.061585516,0.04314588,-0.017591411,0.047333743,-0.022514211,0.011145046,0.022246357,0.09063946,-0.019303123,0.008427108,0.0022529112,0.103391595,0.008457714,0.011371328,0.033620726,-0.005954321,0.035258695,-0.1031305,-0.119054615,0.023924876,0.035472706,-0.07449185,-0.042393256,-0.03195048,0.0038254077,0.022503233,0.018198974,0.06494443,-0.020389222,0.021190051,0.07160613,-0.040958848,0.042181756,0.06399548,0.017205685,0.06283667,-0.00013009329,-0.014802908,0.117345296,0.009425746,-0.055477627,-0.046690457,-0.034351595,-0.027641675,0.0025368128,-0.0037393933,0.022571143,0.044422537,-0.048063464,0.00062488025,0.04809077,-0.041356962,-0.040710565,-0.0634337,0.056644782,0.08513906,0.017157335,-0.042457312,-0.019111406,0.005393898,0.0010341435,-0.10046874,0.028455168,0.016548924,0.0023322196,-0.0111992825,-0.010481237,0.017172335,0.018756822,-0.048457433,-0.026675604,0.015903993,0.010626565,-0.088842206,-0.057531588,0.025543192,0.04331819,-0.06388487,-0.15535685,0.054869913,-0.011668675,-4.4396323e-34,0.08218269,-0.04819003,0.046731774,-0.0506924,-0.12341608,0.018258588,0.0049012266,0.11609192,-0.024505634,-0.023763668,0.05675007,-0.017057376,0.008191666,-0.030204637,0.041251156,0.007570907,-0.04005181,0.0044736164,-0.030753206,0.03717002,-0.029907761,0.10096307,0.026306821,0.020678818,0.040927507,0.035258003,-0.023193402,0.037079845,0.015795592,0.013749176,0.06778128,0.039031878,-0.022834426,-0.011998128,-0.052714963,0.06302185,-0.056754533,-0.008019132,-0.016103871,0.06360607,-0.009840412,0.047710888,-0.03394134,-0.0128673,0.061722994,0.0105683,-0.09329099,0.14570923,0.008412962,-0.032762934,0.05819693,-0.020122992,0.044662558,-0.011161924,0.044191975,0.026597554,0.020037133,0.07311862,-0.03381702,0.0022702971,0.012876254,-0.11614958,0.07159549,0.06389787,0.022577517,0.12231362,0.044539697,0.024943018,0.041928522,0.036863428,0.069802605,0.013888794,-0.040437028,-0.030547252,-0.028590746,-0.041822873,-0.14185934,0.041326843,0.00475663,0.049003813,-0.0775611,0.032761045,-0.014200418,-0.014348215,-0.008466578,-0.090159446,0.02719962,0.100764565,-0.0328144,0.054991033,0.03129657,-0.029982816,-0.057163376,0.025785718,0.08352505,-3.360333e-08,0.12554424,0.030404,0.053608526,-0.00019803457,-0.003981855,0.0030786938,0.004988719,0.045225974,0.045026097,0.040435206,-0.01557614,0.05359192,-0.050344635,-0.041028284,0.080938675,0.033504058,-0.054819405,0.020935787,-0.043722734,0.06673395,-0.017196838,-0.038634166,-0.10850796,-0.009663543,-0.02851635,-0.025145577,0.110646054,-0.020770969,-0.027142616,-0.030054675,0.021212487,0.00589845,0.03784456,-0.12393932,-0.119714126,0.014754007,-0.04654412,-0.04403654,0.02034093,0.08168624,-0.032258987,0.008951412,-0.06487828,0.014565049,-0.012796738,-0.010876576,0.0020425955,0.008654976,-0.013414581,-0.0070296694,0.0005647189,-0.028591802,-0.04688906,-0.0947518,-0.15256669,0.044357866,-0.031448323,-0.027062105,-0.009878713,-0.023208732,0.026396587,-0.003724944,0.12992857,-0.032313697 +4.1.2.62,"The enzyme, originally characterized from the bacterium Rhodospirillum rubrum, is involved in degradation pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are formed from S-adenosyl-L-methionine (SAM, AdoMet) by radical SAM enzymes and other types of SAM-dependent enzymes, respectively. The enzyme requires a divalent metal cation, with Co2+ producing the highest activity.",384,0.99999994,-0.0986582,-0.07575451,-0.10439464,0.068879046,0.06983717,0.051815443,-0.039940804,0.060134847,-0.031696606,0.052700084,-0.028615769,0.0015802908,-0.033375308,0.045255445,0.0005411987,0.04168138,-0.07142154,0.022773992,0.010151606,-0.008947055,0.100197375,0.0038391273,-0.10515289,0.006931649,0.06759131,0.03612619,0.072956294,-0.07611487,-0.07014158,-0.02681052,0.028137082,-0.05729677,0.11344358,-0.039567523,0.03290842,0.105939224,-0.007660589,-0.036531117,0.062918134,0.02769166,-0.04730049,0.07915679,0.050439037,-0.05131747,-0.03646712,-0.05099625,-0.014027912,0.05124695,0.03697997,-0.0110815,-0.090012714,-0.04886166,-0.05537891,-0.00944765,0.02791229,-0.00016787504,-0.028021317,-0.062363744,-0.067715704,-0.010018254,0.07195019,-0.012904421,-0.0016439152,-0.011012424,0.019332996,-0.035970002,0.057815906,-0.07812171,0.057637185,0.010806134,-0.041322347,-0.026213493,-0.038589556,-0.010466665,-0.052918866,-0.009891687,0.021636588,-0.046124067,0.068283565,-0.070509754,0.019362267,-0.0013661605,0.02051914,0.026592396,0.03572472,0.064119026,0.051210698,-0.032472376,0.037302196,0.03928405,0.015963474,0.038452737,-0.044709664,-0.10818308,-0.08168267,-0.0074845566,-0.040134907,0.0456824,-0.023758963,-0.04014039,-0.012031307,0.11671338,-0.045241226,-0.11788969,0.0054509235,0.011688618,0.0073612058,0.08923392,0.038730636,0.05943105,0.043950304,0.04936301,0.0060429503,0.0116048325,0.019749286,0.11445983,0.033499748,-0.056137875,-0.12569275,0.01811871,0.019311238,-0.02210989,0.0116908485,0.017146295,-0.045108575,0.042187516,-0.054510392,2.0893635e-33,0.08918833,0.0075671966,-0.02177741,-0.026504233,0.004105949,0.010666609,-0.11983468,0.029860977,0.015127689,-0.0137082385,-0.08463582,-0.028447455,0.077083774,-0.042808037,-0.042532295,-0.02211155,-0.025823114,-0.0061429823,0.07207117,0.008385535,-0.040249337,0.040519577,-0.061001237,0.028351584,0.02203116,0.11187532,0.07009283,0.0005328549,0.008453662,0.0113160545,0.0175387,-0.104292825,-0.12035474,0.0040510194,0.065252185,-0.026466431,-0.07325499,0.011120247,0.020960487,0.036988184,0.052952986,0.002320874,-0.01052955,0.05931399,0.045988534,-0.05741934,-0.0106088165,0.10894433,0.040830795,0.07333044,-0.009594743,-0.036707897,0.13668413,-0.0014992626,-0.084407054,-0.046190906,0.0026305448,-0.018668117,0.0009759596,0.074111,0.049302306,0.0068757734,-0.01288607,0.039069675,0.015633525,0.017911984,-0.046341944,-0.054805003,0.048637263,0.07475264,-0.012492137,-0.027048618,0.07972568,0.06219478,-0.023024537,-0.053724334,0.00078677025,0.05689256,0.036563653,0.024793472,-0.08453679,-0.013141923,0.046477985,-0.05067635,0.013075916,-0.010308223,0.0028750729,-0.07011325,-0.041058768,0.0055473223,-0.0019165223,-0.06583094,-0.05554297,0.03954967,0.023757502,-2.9983672e-33,0.049553487,-0.072599314,0.015784241,-0.08330117,-0.110214196,0.023066463,-0.022806497,0.033409208,0.0010568593,-0.06618811,0.053373568,-0.024968954,0.05838929,-0.05199842,0.080810115,-0.028835857,-0.020275515,0.02785422,0.0029362238,-0.02196208,-0.010689073,0.091656335,-0.0019443088,-0.005770473,0.106978156,-0.004550793,-0.027309818,0.032804277,0.066312216,0.045202665,0.08006382,0.006395861,-0.054926045,-0.022613153,-0.09038582,0.07076542,-0.022389328,0.031218844,0.000494307,0.020536963,0.033441663,0.032249894,0.018137075,0.10616336,0.042333465,0.06449337,-0.120952405,0.03509759,-0.05367445,-0.078689426,0.016728705,-0.08966764,-0.032355674,-0.006196845,-0.002494256,0.06314743,-0.034497794,0.045724224,-0.068453416,-0.014289897,-0.020360945,-0.08048266,0.026557008,0.023785926,0.0022438543,0.046516865,0.07486162,0.05713456,0.004888158,-0.032216936,0.047542978,0.071137965,-0.0007001334,0.0526711,-0.061171886,-0.005246891,-0.08255196,0.002303489,0.0027698372,-0.042887807,0.021811586,0.015701074,-0.039337054,-0.039277352,-0.016198093,-0.072861634,0.02138721,0.08969976,-0.0010941011,0.040613525,-0.09533361,-0.040446747,-0.08466799,0.027388183,0.034960184,-4.2549214e-08,0.025732176,-0.030119576,0.03528708,-0.047822498,0.034440476,0.10126451,0.02029576,0.024227658,0.03827322,-0.008811655,-0.047364708,0.08274735,-0.015196749,0.006640735,0.011287225,-0.00015138401,-0.049864415,0.031822797,-0.022917619,0.04149047,-0.019519258,-0.06507794,-0.06641967,0.052809414,-0.009217866,-0.030719737,0.08279009,0.009679103,-0.06272719,-0.022600764,0.024129143,0.008837666,-0.0076945745,0.023388905,-0.09474677,-0.024919942,-0.013568376,0.009681323,-0.020431498,0.07128113,-0.048955183,-0.004513139,-0.115948796,0.03466387,-0.016082885,-0.0293116,0.004824443,0.014043142,-0.012606884,-6.133183e-05,-0.014505867,-0.049618322,-0.04087705,-0.07379728,-0.08933483,-0.011635371,0.005912822,-0.031244813,-0.04234329,0.03254335,0.027149994,0.014549149,0.16886823,-0.015777603 +6.2.1.64,"Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form complexes with a cullin scaffold protein and a substrate recognition module, which are known as CRL (Cullin-RING-Ligase) complexes. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. Like ubiquitin, the NEDD8 protein ends with two glycine residues. The E1 NEDD8-activating enzyme activates NEDD8 in an ATP-dependent reaction by forming a high-energy thioester intermediate between NEDD8 and one of its cysteine residues. The activated NEDD8 is subsequently transferred to a cysteine residue of EC 2.3.2.34, E2 NEDD8-conjugating enzyme, and is eventually conjugated to a lysine residue of specific substrates in the presence of the appropriate E3 transferase (EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase).",384,1.0,-0.12720121,-0.010910833,-0.015607964,-0.0684584,0.11469353,-0.0057700723,-0.0035144035,0.049619474,0.042567678,-0.0458057,-0.016961431,-0.010952892,0.019695472,0.041001525,-0.02290377,-0.04300487,-0.052247126,0.023944464,-0.055137977,-0.093571685,0.08560763,0.068953514,0.014683332,-0.0256415,-0.004251024,-0.025051018,0.08703963,0.029351128,0.012747637,-0.09030451,-0.0030304242,-0.057124067,-0.046225805,-0.04293577,0.0065656602,0.13536415,-0.054417636,-0.02008272,-0.071341306,-0.058861937,0.10895312,-0.034825582,0.031107873,-0.015164325,-0.032435123,0.023714036,0.02076175,0.0128667485,0.065055154,-0.016824706,0.028153632,-0.03342578,0.014643018,0.040945303,0.034085397,0.056476302,-0.06876503,0.005794456,0.0017677557,-0.025881672,0.022329355,0.0015557715,0.041223146,-0.023799948,0.024639368,-0.08350377,0.03128169,-0.03709245,-0.0012805973,-0.027490169,-0.006484035,0.019648012,-0.07119163,0.05602352,-0.022713974,0.07921517,-0.07152422,-0.03010843,-0.004953307,-0.031617995,-0.017590297,-0.023276003,0.139117,-0.02293895,0.0728313,0.014940072,-0.045286298,-0.019259373,0.041230667,0.045421295,0.03584582,0.024343528,-0.013516975,0.05859273,-0.02137976,-0.0030502353,0.050371695,0.038806427,-0.05358649,0.04553995,0.02740773,0.13350011,-0.03207367,0.0054471213,0.012087871,0.03474796,0.030839076,0.062354494,-0.055166304,0.00056761457,-0.048733614,-0.00014128546,0.0777876,-0.046781827,-0.0057153055,0.10113174,-0.046945564,-0.024871768,0.013085926,-0.021804878,-3.5379e-05,0.036768284,-0.026843064,0.062542625,-0.021433929,0.031635117,-0.07203025,4.7646496e-33,0.00487734,0.046691287,-0.058551513,0.0367981,-0.06738087,-0.02343242,-0.13438188,0.034952614,-0.014537336,-0.0632029,-0.034876958,0.000749457,0.05070679,0.023398038,-0.021072648,-0.071366824,0.0042941435,-0.009485219,0.040764652,0.023360124,0.008946249,-0.013103947,-0.024003653,-0.0012929363,-0.0025585413,0.019974647,-0.0021790294,0.06283395,0.08032177,0.00057249755,-0.03139388,-0.06885873,-0.07188752,-0.008923669,0.009108326,-0.014276144,-0.01628953,-0.015277929,0.024497794,0.032768626,0.044968173,-0.010212408,-0.088508815,-0.050859615,0.04342494,-0.06538287,-0.018503005,0.08711802,-0.045616753,-0.021560527,0.13511439,-0.0682379,0.053101353,-0.08825966,-0.07733702,-0.028186748,0.0038270392,0.0008289309,0.03247948,0.024549797,0.039326876,0.023747493,-0.03440763,0.07250428,0.030944826,0.09559205,-0.09819501,-0.10338579,-0.005869938,0.050250113,-0.051824916,-0.018427085,0.0856572,-0.0018060524,0.053902775,-0.07169081,-0.094326854,-0.013789834,0.04128652,0.07882371,-0.027555829,-0.00023408874,-0.09446907,-0.03654528,-0.02689755,-0.06108076,-0.015719626,-0.053858146,0.002034216,-0.0201154,0.13381878,-0.06542777,0.0056310785,0.056994274,0.03852494,-4.978055e-33,0.07674067,-0.036309958,0.06522417,-0.005987564,0.021984054,0.064265914,0.07143553,-0.034922615,0.034118064,-0.100877166,0.08562477,-0.099025205,-0.024823405,-0.012192235,0.01721487,-0.04927073,-0.04793267,0.0686129,0.02313222,-0.0064827646,-0.013283638,0.010037814,0.00014378218,0.07690628,-0.0057193083,0.04296406,-0.09138368,0.045893107,-0.02165572,0.046041694,-0.027303234,-0.030313704,-0.06464513,0.13420156,-0.067318335,0.07587261,-0.007498779,0.0073237363,0.06741738,-0.045491867,0.10142047,-0.009455892,-0.045854323,0.10075589,-0.005160003,0.0668165,-0.046735115,0.04075819,-0.047888953,-0.06024044,0.037191853,0.072307594,-0.07890455,-0.02663273,-0.018106045,0.10282239,0.09379288,-0.041145943,0.0452981,0.030182544,0.003953467,-0.008545861,0.0012843426,0.03293996,0.025984166,0.0057149064,-0.030767301,0.106537715,0.06826058,0.0263125,0.038067803,0.019039765,0.06605379,-0.027267361,0.056691375,0.013524508,-0.006100714,0.0046678893,-0.01990278,-0.054918192,-0.07081234,-0.026803246,-0.008485379,-0.03758383,-0.0026158588,-0.014646719,0.016736537,0.04908773,0.03424151,-0.02913518,0.001908626,-0.032992978,0.0020107569,0.10605404,0.10474701,-4.5992977e-08,0.057362072,-0.057370335,0.025273222,-0.08691165,0.034111284,0.019527404,-0.016065188,0.02662786,0.034219112,-0.04637879,-0.056429263,0.05486984,-0.020474305,-0.05127922,0.050378133,0.094382115,-0.033776008,0.064034924,0.012868665,-0.07529183,0.005382462,-0.01896875,-0.089961976,0.042788006,-0.025877934,-0.04737337,0.017967395,0.09541085,-0.019620622,-0.052264456,0.0046386113,0.00011735237,-0.021428829,-0.025794616,-0.012998433,0.04395739,-0.013609736,-0.03283216,-0.05620752,-0.035386503,-0.023648433,-0.004581949,-0.09357705,-0.058650464,0.02916765,0.012525832,0.043082897,0.028913483,-0.06177181,-0.009299519,-0.01707073,-0.01702449,0.024138834,-0.08223714,-0.06780363,-0.01624309,-0.084715985,-0.09898952,-0.01625888,-0.09194823,0.004487545,0.004681643,0.06268561,-0.056920547 +6.2.2.1,"Requires Mg2+. The enzyme is found in anaerobic methanogenic and methanotrophic archaea, where it modifies a glycine residue in EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase (methyl-CoM reductase). Upon binding to its substrate, an external source of sulfide attacks the target amide bond generating a tetrahedral intermediate. The amide oxyanion attacks the gamma-phosphate of ATP, releasing ADP and forming a phosphorylated thiolate intermediate that collapses to form thioglycine and phosphate. In most organisms activity requires a second protein (TfuA) , which may allosterically activate this enzyme or assist in the delivery of sulfide to the substrate.",384,1.0,-0.04928889,-0.061581153,-0.017965415,-0.009925227,0.023186356,-0.043113388,-0.054999314,0.03345742,0.020206759,0.03211057,0.0051888996,-0.016809177,-0.009164614,0.041204233,-0.003095252,0.033791915,0.009619067,0.022140251,0.026538968,-0.062390357,0.09854363,0.08593743,-0.03498577,-0.023367636,-0.03597,0.00849048,0.030530395,-0.01931214,-0.03216132,-0.0005629651,-0.07513028,-0.029578742,0.03901693,-0.06660637,-0.003500267,0.17334548,-0.047250815,0.0014099502,0.017624319,-0.10040332,0.021339767,-0.02380591,0.055180706,-0.030058768,-0.023762068,-0.07888303,0.09807953,-0.021941505,0.057583705,-0.05078552,-0.07935365,-0.020830145,-0.06495801,0.049190722,0.028802434,0.048647504,-0.055674206,0.021660225,-0.010295171,-0.058703706,-0.03197409,0.006660676,-0.0011857734,-0.032491542,0.06577744,-0.041981436,0.06326812,-0.051839344,0.03333353,0.0033644545,-0.050692018,-0.0039535626,-0.038937803,-0.01461085,-0.057729747,0.049378708,-0.03557956,-0.06490411,0.07701261,-0.038177885,0.043216724,-0.012683102,0.07219487,0.033984814,0.068963185,-0.07560984,-0.00212957,0.04740554,0.049034934,0.030361101,0.04906652,0.046356063,0.022164652,0.006181614,-0.048398994,-0.0292262,-0.043593183,0.04073745,-0.015259132,0.006422424,-0.004063635,0.08770143,-0.038010158,0.0026572652,-0.007026812,-0.004609413,-0.0209229,0.07583101,0.05044862,0.069556296,0.07362582,0.031423166,0.061372105,0.012964609,0.009317846,0.1317961,-0.0012600003,-0.08188149,-0.056739807,-0.01911824,-0.017345712,0.0021284954,0.02162996,0.024810992,-0.0009651108,0.0025645755,-0.1367433,2.8311118e-33,0.10233536,0.07150961,0.057050616,0.042097587,-0.029934263,-0.02493074,-0.09495954,0.0073074084,0.050389234,0.007068962,-0.055541947,-0.06978499,0.055005256,0.028597852,-0.043489955,-0.07436761,-0.021499384,0.034733012,0.09224049,0.037070192,-0.07747485,0.047615916,0.033650186,-0.05305766,0.028900674,0.035530314,0.019277083,-0.01184706,0.047339372,0.03507122,0.019889498,-0.1883076,-0.096799545,0.0060352613,0.09552818,-0.019256856,-0.06780389,-0.014741802,-0.03546262,0.007917866,-0.009367733,0.011594446,-0.020403003,-0.0010979122,0.060107935,-0.062331267,-0.024872974,0.059332896,0.018858088,0.06745803,0.06477503,-0.08971387,0.068214685,-0.0018696416,-0.12784,-0.014956319,-0.0042572278,-0.043574743,0.061204206,0.0984578,0.004810504,-0.014899956,-0.04588619,0.07144525,-0.010214532,0.018566564,-0.09425948,-0.058152888,-0.021647695,0.13859192,-0.0009976798,-0.062171515,0.050104443,0.037198067,-0.037136186,-0.045088004,0.01866385,-0.017593917,0.03354346,0.019281998,0.0045304354,-0.05593212,-0.025983287,0.015179671,-0.07376947,0.014594836,0.0010033037,-0.024540596,0.03552481,-0.027014807,0.009640492,-0.011913221,-0.052812755,0.056668296,0.02080969,-3.501397e-33,0.07799198,-0.034893908,0.036269873,-0.09927974,-0.04842189,0.034231223,0.04703121,-0.07143775,0.05765448,-0.070458345,0.065423824,-0.013338946,0.03866396,-0.08031278,0.02017556,-0.07558721,0.015856434,0.03958236,-0.05058654,-0.051297378,0.017045978,0.058556244,0.012370975,0.030055678,0.042813618,0.044754505,-0.029369108,0.07732889,0.033567462,0.096772656,-0.0078101074,0.049387064,-0.0630983,-0.03532999,-0.054617207,0.090958826,-0.07876554,-0.0058826064,0.006653674,0.042853422,0.04936846,0.075856514,0.04023731,0.10887605,-0.005829462,0.051814403,-0.026228653,0.050709274,0.0015481138,-0.09793606,0.06349238,-0.065940514,-0.03323593,-0.041295793,0.0376807,0.068995416,-0.030459734,-0.003168044,0.019178247,-0.014667929,-0.009502419,-0.04357039,0.033598475,-0.049261276,-0.003177893,0.031497415,-0.007825767,0.0066885925,0.0074563767,0.090127006,0.021385666,0.04664815,0.021648493,-0.010353614,-0.0052277334,0.043504275,-0.09372163,0.0028511714,0.039769594,-0.048179813,-0.008139268,0.053118277,0.024935998,-0.06996657,0.014917131,-0.12522021,0.00068715913,0.083753735,-0.0032438447,-0.026370669,-0.07924016,-0.052127715,-0.040929265,0.06564916,-0.031448983,-4.7730435e-08,-0.02288795,-0.03135852,0.06276933,-0.018143214,-0.0109839225,0.06730765,0.035800695,-0.00014634058,0.066124685,-0.04000566,-0.025122156,0.035382077,0.008261848,-0.013961171,0.0006220248,0.082715124,-0.058792144,0.019254604,-0.08509874,-0.080275245,-0.039694987,-0.07439191,-0.11049627,0.04269528,0.038934298,-0.03495264,0.0013167986,0.031892315,-0.02931131,-0.055190932,0.044488136,-0.0034131892,-0.021011433,0.0017177345,-0.08181485,0.039328057,-0.049698513,-0.01351832,-0.054043554,-0.045373403,-0.06785425,0.01443938,-0.037648313,0.036027126,0.025211155,0.027972404,-0.01736731,0.09175743,-0.09345708,0.035244264,0.023913102,-0.021374155,-0.0035184596,-0.052266493,-0.08116684,-0.025244566,0.016142141,-0.036271404,0.0060843895,-0.038645856,0.06804735,0.0038777709,0.112763114,-0.07732091 +6.5.1.9,"The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions.",384,1.0,0.046646725,-0.0488373,-0.036942046,-0.022091229,0.016231792,-0.008604041,-0.0066345977,-0.034713246,0.0692218,0.044175964,-0.03729005,-0.09693134,0.018002102,-0.022235064,-0.075223915,-0.014835149,-0.033588305,-0.015212779,0.04097477,0.017262943,0.12161413,0.028998898,-0.0045081573,-0.00074547814,0.034473877,0.012221644,0.022019157,-0.0254188,-0.0637546,0.039384678,-0.03955004,-0.006642286,0.14453797,-0.026418723,0.06189012,0.1251291,-0.09242366,-0.0061273174,-0.022891875,0.0086881,0.050395723,-0.009085421,0.079700135,-0.016197287,-0.023417633,-0.017289493,0.03433053,-0.04017653,0.06495084,-0.034759905,-0.0325727,-0.09445363,-0.019111035,0.11499637,0.023269175,0.08851895,-0.064681426,0.053126175,0.009210094,-0.023778804,0.062019467,0.045499865,0.009855819,0.01669686,0.03442945,-0.05977116,0.04750773,-0.025614496,0.10643008,-0.04700844,-0.0069291876,0.009582217,0.03251932,-0.105432905,-0.0053796135,0.018326767,0.025233412,-0.08702954,0.053506687,-0.10854063,0.03435931,-0.04089445,0.01225509,-0.04435586,-0.031722955,0.026773157,0.040985186,-0.030231845,0.041907776,-0.012918474,0.018479794,-0.017998157,0.08279233,-0.09462003,-0.06543856,-0.004005091,0.021766467,0.0073328917,0.05183247,-0.009036288,0.013287837,0.09405334,-0.051237512,-0.06794491,-0.07119804,-0.0030097656,-0.023441005,0.03687734,-0.012696514,0.077587344,0.039768938,-0.0073169866,0.07031186,0.033405673,0.029891383,0.09654063,0.0024256718,-0.11667303,-0.037576884,0.062423505,-0.040395554,-0.042540696,0.03018557,0.049096543,-0.023994377,0.10609742,-0.054716874,1.43938705e-33,0.07990856,0.023772558,0.026671818,-0.016009158,0.016019674,-0.07690675,-0.062960304,-0.04330087,-0.026000295,-0.063623846,-0.026076652,-0.013429464,0.07407181,-0.01140145,-0.0060015474,0.0088175535,-0.041714933,-0.0028979806,0.083314784,0.055529695,-0.043426044,0.021157619,-0.03476219,-0.0058554513,0.04239935,0.03328973,0.009344836,-0.02116534,0.03030641,0.015735947,0.06703191,-0.080221556,-0.16412717,0.029412894,0.06206302,0.007091902,-0.04337415,0.013620277,-0.05443305,0.058414273,0.015594998,-0.0098712575,0.044541463,-0.016904594,0.08556224,0.018465733,-0.069259115,0.15279622,0.05943045,0.060477763,0.019532802,-0.0051837536,0.10493347,-0.0017101242,-0.085725896,0.043098424,0.0090187155,-0.047304288,0.05792409,0.026642766,-0.02740994,0.06252189,-0.011250408,0.073609956,-0.010888155,0.016833466,-0.06608672,-0.025080876,0.05061296,0.09050666,-0.10725871,-0.0058409516,0.014393541,0.050088808,0.011152315,-0.020642435,-0.04799889,-0.06452531,-0.044533733,0.048697926,0.037065953,-0.11255345,0.042900845,-0.028579144,-0.04383473,0.007395141,-0.02915384,-0.032826837,-0.015428982,0.09791929,0.006699343,-0.03496448,-0.04687645,0.09272668,-0.058291703,-2.0735441e-33,0.09447594,-0.064237475,-0.00022655491,-0.029261867,-0.07082215,0.062224176,-0.037451208,-0.014662361,-0.041465137,-0.06396642,0.09658524,0.008939612,0.09742861,-0.02968677,0.056917693,-0.016823713,0.011597729,0.08773009,0.024616359,0.024909034,0.050481666,0.009859787,-0.0218928,-0.023647796,0.03890836,-0.012395786,0.022854082,0.066361465,0.0086185,0.033508986,0.006541742,-0.0034919672,-0.061189286,-0.099482186,-0.10084535,0.0046526925,-0.060511693,-0.07252758,0.052043866,0.039898913,-0.0071166055,0.043151364,0.006961016,0.0725393,0.013830206,0.0120599745,0.0011644652,0.019623155,0.097803,-0.038545508,0.042971533,-0.12869975,-0.040088747,-0.002751198,0.029799812,0.055882525,-0.056454074,0.09693766,-0.03824695,-0.044297915,-0.054028254,-0.07693645,0.083625585,-0.036753453,0.020720549,0.034173932,-0.026786912,0.013949402,-0.022947934,0.021388765,0.032623887,-0.004394227,0.045110926,0.022857366,-0.003962455,-0.00863881,-0.037982274,0.027341621,0.04145573,-0.06130653,-0.04351724,0.07394623,0.049231805,-0.033140965,0.017361142,-0.085520394,0.04589189,0.03399374,-0.061858423,0.009275062,-0.043222014,-0.06611243,-0.039714113,-0.023845538,0.05230084,-2.915827e-08,0.070848405,-0.023428718,0.025038257,-0.035060972,0.024809208,0.03525572,0.067033395,-0.0021044242,0.0047051487,-0.069230184,0.00088110403,0.068858236,0.058981422,0.024999486,0.009978463,0.051074833,-0.054325745,-0.012211208,-0.09201137,-0.039843153,-0.012098125,-0.1015879,-0.049134318,0.01808565,-0.0050796554,0.02274383,0.0067963847,0.01469063,-0.03973006,-0.033254143,-0.07378734,-0.018831247,-0.016215976,-0.0642473,-0.042032022,0.028584238,-0.061887305,-0.031362776,-0.045421112,-0.03185196,0.011816234,-0.040147193,-0.025421215,0.017590227,-0.050136838,-0.048053186,-0.056865923,0.06529437,-0.0069638495,0.04087978,0.037925363,-0.032674283,0.027350698,-0.041070793,-0.06886953,-0.08259999,0.0546017,-0.08201796,-0.0338541,0.018202608,0.04254185,-0.028218688,0.03680749,-0.061976764 +1.1.1.424,"The enzyme, which participates in the degradation of D-xylose, has been characterized from several halophilic archaeal species. cf. EC 1.1.1.179, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming).",384,0.99999994,-0.009917702,-0.05396125,-0.0010639739,-0.06102145,0.06749037,0.0013207201,-0.054740857,0.026418863,0.022886464,0.0060580443,-0.028755195,-0.040306438,-0.053751916,0.05493455,-0.054148592,0.042971745,-0.039671365,-0.01688371,-0.0020294203,0.031233171,0.08116922,0.08648074,-0.001835979,0.017715244,0.074214935,-0.0070792288,0.07461976,-0.06912838,-0.065898694,-0.06648263,0.00081046927,-0.07951864,0.0912133,-0.00820955,0.0843071,0.10000776,0.01657525,-0.04584429,0.059209365,-0.032823715,0.01442964,0.012962489,-0.022693872,-0.012143594,-0.095035575,0.0067096753,-0.066815406,0.047783922,-0.013687567,0.0069823777,0.008909757,-0.05667407,-0.03048466,-0.016183857,0.073292464,0.025155159,-0.0072789807,-0.06786574,-0.08253365,-0.069067925,0.09144001,0.06357596,0.043113284,0.019456783,-0.019155802,-0.06194162,0.11071773,-0.0618804,0.04999484,-0.04675367,-0.11332128,-0.06460123,-0.03372596,0.003180127,-0.016294222,0.024011519,0.026751498,-0.14432634,0.032686725,-0.09673141,0.058506403,0.044773012,0.044526704,0.031334903,0.023251116,-0.03898378,0.068451114,-0.0040194923,0.028411226,0.01707933,-0.004973415,0.00060458196,0.0025583755,-0.053651072,-0.050990324,0.007590621,0.094996616,0.016451264,0.018801637,-0.035360444,-0.031425305,0.037431106,-0.0074670673,-0.087957315,-0.10705588,-0.03152782,-0.036914293,0.11327152,-0.037527606,-0.040533554,0.033315536,-0.06137123,0.04225942,0.06723696,-0.011748715,0.059562344,0.045988407,-0.032872245,-0.122777365,-0.003302389,-0.03588708,-0.037241448,0.04855387,0.079866126,-0.039756402,0.046482235,-0.06949134,-1.5993374e-33,0.06776253,0.028527303,-0.055880666,-0.03292017,0.022905441,-0.040954776,-0.043841805,0.08083769,-0.094410904,0.01170858,-0.028222336,-0.07957312,0.03039965,-0.034225713,-0.0054220445,0.022207884,0.002404464,0.031261448,-0.009867303,0.03535298,-0.056461178,0.08091251,0.008319345,-0.013761782,0.06825897,0.027314458,0.004549088,0.038455963,0.022885453,-0.019320263,0.0058774156,-0.15369886,-0.07914047,0.08563334,0.08499649,0.071934484,-0.027477184,-0.020021021,-0.045506947,0.0068176324,-0.055272788,0.03717013,-0.021203201,-0.084261,-0.008651281,-0.016768191,-0.038181618,0.034454316,-0.015832186,0.021804472,0.021633254,-0.00068405026,0.07861117,-0.006245358,-0.03768786,0.026410557,-0.038714234,-0.004540352,0.051467583,0.014949099,0.02187437,0.037988562,-0.05739192,0.03242623,0.07744016,-0.029935801,-0.034570627,-0.027879637,0.012872185,0.036781125,-0.07917183,-0.077778876,0.056967966,-0.020066055,0.03441499,-0.032595035,-0.07198664,0.030370492,0.006698991,0.016851803,0.018030992,-0.046113756,-0.009621695,-0.07727283,-0.015422539,0.09456296,-0.011632269,-0.028697029,0.005372206,0.08452403,-0.005295559,-0.07798114,-0.00013031809,0.0032961976,0.025139073,-4.2812165e-34,0.017275289,-0.041584805,-0.011412206,-0.0077052223,-0.058573533,0.13492027,-0.016562508,-0.005356167,-0.023356266,-0.07678331,0.11512427,0.059877716,-0.016497087,-0.04481749,0.029350786,0.03798871,0.046890654,0.0060169087,-0.03816951,-0.003891857,0.051378537,0.07205533,-0.05460996,-0.0038526312,0.04120837,0.01817725,-0.020139337,0.074918926,0.087249555,-0.021629754,0.038960632,0.08089952,0.029013092,-0.0251442,-0.06210516,0.017067164,-0.08834575,0.030547138,-0.011113556,0.069412686,-0.022643534,0.058614396,0.016153106,0.053252615,0.056138165,0.05973573,-0.045773312,0.0029695404,0.10634463,-0.015226087,0.013191133,-0.038413316,0.013639776,-0.03105204,-0.00019042728,0.07035381,0.01520347,0.10847682,-0.00036783758,0.0109792035,-0.065333694,-0.045991488,0.11873287,0.023374679,0.05239085,-0.026303489,-0.03939613,0.028973132,-0.031039791,-0.05602685,0.054733213,0.0063114073,-0.031529773,0.064201064,-0.05408398,-0.044323463,-0.08477856,-0.0035200787,0.032010473,-0.001168358,0.052212812,0.023725249,0.022194576,-0.027676007,-0.009510426,-0.09082941,0.025295801,0.084699206,-0.035253547,0.012754936,-0.035978597,-0.03360145,-0.072957344,-0.052417386,0.08876611,-3.314597e-08,0.056032494,-0.020439409,0.017908955,-0.04863589,0.024414042,0.011208028,0.07055819,0.028769877,0.098998256,-0.042336617,-0.010313546,0.10046437,0.019616414,0.03451312,-0.0004291118,-0.017854953,-0.011300912,-0.0051124254,-0.03350433,0.0039911633,-0.05791248,-0.04254475,-0.089924,-0.021901185,-0.009901354,-0.08227755,0.053530537,0.00665651,-0.0020696158,-0.042369574,-0.045858722,0.07992251,0.045455802,-0.031852875,-0.027965665,0.028056353,-0.09698915,-0.03212734,-0.0014890681,0.06245466,-0.02345784,0.010281435,-0.059311967,0.026082387,0.027016994,0.02036351,0.047026932,0.0115375575,-0.07201699,0.017556727,0.04351624,0.004111337,-0.006463651,-0.09186238,-0.068599254,0.034019966,0.023684464,-0.055506453,-0.059671417,-0.042782463,0.05540476,-0.0527843,0.15470949,-0.07810281 +1.3.3.16,"Contains FMN. This enzyme oxidizes 2-oxazoline, 5-methyl-2-oxazoline, and 2-thiazoline within peptides, which were formed by EC 6.2.2.2, oxazoline synthase, and EC 6.2.2.3, thiazoline synthase, to the respective pyrrole-type rings. The enzyme is found as either a stand-alone protein or as a domain within a multifunctional protein (the G protein) that also functions as a peptidase.",384,1.0,-0.04734377,-0.0444443,-0.10702873,-0.007629239,0.072060615,-0.014893629,-0.013349129,0.08150712,0.05942685,-0.013300464,0.0070572295,0.02592851,-0.067719035,0.031312846,-0.023778608,0.072343074,-0.079553574,0.0051026004,-0.023837449,-0.09713915,0.041415315,0.062443018,0.0462491,0.024185281,-0.08883304,0.020558124,0.017437264,0.073794015,0.029758422,-0.10233584,-0.009313107,-0.007674398,0.027087832,-0.01276311,0.046501987,0.0078013614,0.01392284,-0.062486824,-0.0043036127,-0.014692603,0.06199537,0.029428953,-0.022539526,-0.09203426,0.024954269,-0.037860386,0.029633043,0.04842473,0.02590686,0.0648683,-0.06441245,-0.07627775,-0.037903015,0.05149323,-0.045777433,0.06913546,-0.027116837,-0.041121643,-0.07728891,0.055454522,-0.025725473,0.09356852,-0.015408968,0.0036750461,-0.0070978645,-0.024257783,-0.015409588,-0.08089296,0.012653601,-0.04464912,-0.073862925,-0.14545313,-0.0016428814,0.00045171008,0.0041662697,0.026171908,0.03213473,-0.055242907,-0.0058520883,-0.044709273,0.056929827,-0.00012265726,0.03614222,0.08843079,0.030392587,-0.016750412,0.021038402,0.00827711,0.0706386,0.015189389,0.047422614,0.024146322,0.022004537,-0.011645715,0.0027129608,0.03993519,0.012334722,0.076109596,0.005308679,0.012271112,0.053255767,-0.010310217,-0.00080004294,-0.044485644,-0.019018918,0.066514224,0.05921044,0.091999985,0.047188565,-0.05578736,-0.044434045,0.022017628,0.06505643,-0.03678998,0.015602497,0.043483596,-0.005050495,0.02440693,0.003954123,0.030480077,0.055953946,0.010818733,0.052981976,0.065036476,0.009830839,0.010209016,-0.15779799,1.2543152e-33,0.018083593,0.0582026,0.07428286,-0.026816852,-0.049103618,0.028544782,-0.035663582,0.017988637,0.008709761,-0.014216485,-0.10235705,-0.018859347,0.0043455437,0.01638381,-0.036617886,-0.068179734,-0.02363117,0.03623061,0.054806523,0.024214348,0.059680868,0.030290285,-0.036352463,-0.010023482,0.026368681,0.072588734,0.033983033,-0.008661383,-0.0012126009,-0.0066692787,-0.04698489,-0.09469591,-0.10556608,0.0106742615,-0.00076664326,0.009337189,-0.04646646,0.011875755,-0.03180277,0.055415235,0.008124841,-0.016870476,-0.043348078,-0.030372744,0.06552125,-0.06570116,-0.111099176,0.116519675,0.06981909,0.037897907,0.044690352,-0.080175534,0.09828659,0.04844251,-0.049079042,0.0011900311,-0.06547265,0.00524317,0.08582806,-0.025246639,0.016600126,0.021941716,-0.062239483,0.027890898,0.010331283,0.010863539,0.00029664545,-0.07556798,-0.0019925074,0.13242893,-0.02188085,0.06239545,0.0631759,0.086894624,0.056404296,-0.108916484,-0.12595442,0.004725042,0.04753977,0.050267044,0.02808817,-0.042164385,-0.03309907,0.02451215,-0.050918605,-0.059757464,0.02777966,0.008862549,-0.03193954,0.03194206,0.06068028,-0.093080066,-0.063523404,0.019679612,0.03340338,-9.362033e-34,0.04313689,-0.047419433,0.0035176028,-0.018130256,-0.05811895,-0.05518215,-0.024379974,0.015055023,0.04123226,-0.0020603829,0.05920321,-0.03121823,0.017571805,-0.116057895,0.04059565,-0.0040044743,-0.056601547,0.02160619,0.07332943,-0.00850362,-0.049040522,-0.045276962,0.004362049,0.06429032,0.035228606,0.035123546,0.026934559,0.012415285,0.09191282,0.03899751,-0.046758648,0.054917034,-0.032644667,-0.072216816,-0.0062863436,0.048742324,-0.073945954,-0.0015787893,-0.004853908,-0.049727656,-0.00045204835,0.052124687,0.07490988,0.05016317,0.04128507,0.11652656,-0.027855212,-0.007864889,-0.010493649,-0.01306416,0.05643784,-0.027115466,-0.028716058,-0.015492977,0.06734004,0.018705111,-0.026454117,0.03876193,-0.035108212,0.005583116,0.008259714,-0.06187046,-0.01783138,-0.018410215,-0.00083754165,0.032577,0.02322757,0.08187697,0.06744737,0.059277173,0.07881095,0.029741157,0.048674278,0.007906045,-0.0443631,0.07421609,0.0040936316,-0.032301366,-0.005281612,-0.09399313,0.05282447,-0.04423509,0.022477312,-0.048929095,-0.06873431,-0.011167173,0.030359248,0.14072475,0.004251936,0.05821478,0.018794723,-0.010742362,-0.034407806,0.04231659,0.009252757,-4.3909008e-08,0.04032718,-0.1003544,0.05403643,-0.05488895,-0.0027668385,0.10082228,0.073117405,-0.0024203055,0.036690135,-0.03225679,-0.013737007,0.045827728,-0.011942861,0.008192195,-0.001686997,0.02965337,-0.02478675,0.081904635,-0.0033827797,-0.031747602,-0.039605442,0.04795384,-0.11772801,-0.012495681,0.0124301715,-0.048406187,-0.004392745,0.01584823,-0.01510344,-0.034812625,0.011274439,0.022370026,0.019769182,-0.055868626,-0.07317229,-0.019970102,-0.013235506,-0.06947405,-0.09677889,-0.0767745,-0.023303885,-0.04244751,-0.04144271,-0.07730067,0.0050109862,-0.068794094,0.0036091118,-0.006471408,-0.025531564,-0.030320695,-0.0072291074,-0.0077481973,-0.0098676765,-0.09717906,-0.1122349,0.04086351,0.019570205,-0.044221155,-0.0172576,-0.13014598,-0.041807298,0.01619331,0.19472699,0.015688429 +1.14.11.73,"The enzyme, characterized from humans, catalyses the stereoselective formation of the (2S,3R)-hydroxy-L-arginine stereoisomer. So far the enzyme has been shown to act on two substrates - the 40S ribosomal protein S6 (RPS6), which is hydroxylated at R137, and, at a lower activity, RCCD1, a protein involved in chromatin stability, which is hydroxylated at R141. Even though the same stereoisomer is produced by the bacterial EC 1.14.11.47, [50S ribosomal protein L16]-arginine 3-hydroxylase, the two enzymes do not exhibit any cross-reactivity on their respective ribosomal protein substrates.",384,1.0,-0.0222962,-0.13862382,-0.10684909,-0.12887436,-0.0002704862,0.072223276,-0.11359969,-0.0050149895,-0.035696942,0.02190855,-0.021556051,0.025247265,0.009558411,0.068696834,-0.0063561588,0.06318143,-0.10656891,-0.024778584,0.050073765,0.017675903,0.0017909226,0.031068902,-0.046993837,0.009284748,0.06063848,0.015126457,0.073913574,-0.0016529679,-0.025003608,-0.0785081,0.06700505,-0.021617489,0.0737559,-0.028698452,0.028274862,0.03199493,-0.046021126,-0.05881518,0.08257916,0.0008987025,-0.026070187,-0.016941505,0.008789743,-0.07788338,-0.0033738562,0.0031358027,0.023334028,0.05659629,0.02118339,0.02365247,-0.005281961,-0.024815105,-0.031465065,-0.011272659,-0.024492182,0.043533318,-0.010035425,-0.043651145,0.012150346,0.03360536,-0.054654866,-0.015562134,0.020962218,0.009078429,0.01103531,-0.07504599,0.033931285,-0.021577457,0.02526033,0.05198042,0.002848516,-0.100925036,-0.061610766,-0.012637236,-0.0023860012,-0.045698225,0.023148343,-0.06603375,-0.0005609876,-0.06315729,-0.054884527,-0.02778491,0.03415191,0.10395746,-0.014020165,-0.058674656,-0.020598158,0.05026617,0.061415415,0.011222401,0.0402212,-0.018391306,0.0066938424,-0.039349873,0.032236744,-0.018423641,-0.029483777,0.047621895,-0.0011232952,-0.07664033,0.069689505,0.017901203,-0.031638402,-0.05069946,0.076728836,0.046829574,0.0066725155,0.1331611,-0.03748067,0.00037565693,0.021103745,0.055121448,0.015337627,0.030896982,-0.033590876,0.07730957,0.04926865,-0.071715884,-0.04939968,0.02158112,6.977759e-05,0.06074018,0.110940285,0.021983927,-0.06381548,-0.010130969,-0.06552434,1.812377e-33,0.008552999,-0.015007484,0.0054981904,-0.010591527,-0.017742643,0.023720546,-0.07133879,0.032966647,-0.04676182,0.00496545,-0.09462173,0.015369313,0.06564166,-0.007123415,-0.06467587,-0.0037478125,-0.036758155,0.03753837,-0.058174547,0.0029119626,-0.067929566,0.044851076,-0.006492895,0.027032904,-0.0052279443,-0.0017073476,0.069904186,0.0062746033,0.044628616,-0.012990645,-0.025649933,-0.010618859,-0.06915435,0.032439258,0.03501594,0.054377124,-0.014879055,-0.00075705093,0.041476537,0.06497753,0.071705416,0.035048112,-0.035564873,-0.100718684,0.09924299,-0.040331677,0.03651316,0.08013733,-0.07568553,0.046074934,0.10579563,-0.010468909,0.048026714,0.004051714,-0.0064753625,0.04288986,-0.05282771,0.068987,0.09840531,0.015258116,-0.02233783,0.039001048,0.021315023,0.036175974,-0.020546826,0.027352659,0.00022714822,-0.09895675,-0.078380845,0.07827071,-0.02214187,0.014345006,0.10320044,-0.0021318644,0.018637458,-0.039831568,-0.07667354,-0.0023985296,0.051720455,0.053457677,-0.011699469,0.027586685,0.00908486,-0.027632425,-0.05741279,0.004008935,0.04786524,-0.065052435,-0.03598877,0.077335514,0.12234619,-0.098015755,-0.099668585,0.05923468,0.00951058,-3.088955e-33,0.067077436,-0.16626549,0.08826972,-0.06598759,-0.06683349,0.013756069,0.10763909,-0.022617068,0.01031544,-0.055481344,0.08572982,0.026919017,-0.024366088,-0.0717789,0.03149795,-0.047372963,0.027281243,0.051837947,-0.0077130976,0.009611756,0.018794646,0.042855073,-0.04360531,0.09710403,-0.07825343,0.019036513,0.017112143,5.5988112e-05,0.07363544,0.058844704,-0.0013177264,-0.0065208473,-0.034360293,-0.04465516,0.027620958,0.098937824,-0.06728256,0.044190623,-0.03590204,-0.06754093,-0.07217555,0.09406492,-0.03292752,0.033807892,0.07828378,0.02864476,-0.024499739,-0.02672329,-0.097774796,-0.09482112,0.025916105,-0.07490311,0.06728541,0.004538768,-0.00894515,-0.057569616,-0.036404274,0.008756323,0.038465172,-0.010050357,-0.0065369457,-0.022007812,-0.006653664,-0.022447435,0.037644792,0.054879017,-0.01776894,0.017919032,0.033375304,0.022024693,0.050342213,-0.00039855076,0.015866725,0.03990271,0.042082667,0.027524084,-0.0751735,-0.053718187,-0.03230369,-0.06876545,0.014914112,-0.005959667,0.0023864976,0.054722697,-0.026980674,-0.11498045,0.043594033,0.12569074,0.018885288,0.045430753,-0.023457032,-0.052443333,-0.0903534,0.020467857,0.13133043,-4.3094172e-08,0.056628834,-0.012605472,0.06636427,-0.018997952,-0.042173777,0.066767074,-0.032183185,0.026787521,0.07036117,-0.06514009,-0.01607521,0.019566158,0.0071108807,-0.02567131,0.011449977,0.003017242,-0.051426187,-0.0067502433,-0.0012940142,0.011695621,-0.03182471,0.085329525,-0.022240339,-0.019036448,-0.0780275,0.016152665,-0.018647937,0.026404986,-0.0077595003,-0.1084956,0.048345424,0.043661747,-0.004115302,0.016152853,-0.061869685,-0.016761508,0.011631478,-0.03438708,0.05135836,0.007250083,-0.010705949,-0.023260852,-0.09547022,-0.04945908,-0.025288424,0.01299933,-0.02958249,0.02696093,-0.04058826,-0.03616513,0.06933885,0.04466796,-0.0008522711,-0.050739586,-0.030997787,-0.0046679624,-0.08655125,-0.11036766,0.025324479,-0.052599765,0.0014346183,-0.033897422,0.0813068,-0.05872248 +1.14.11.74,Requires Fe2+ and ascorbate. The enzyme has been characterized from the bacterium Pantoea ananatis.,384,1.0,-0.015481109,-0.03178541,-0.11070373,0.06925571,0.06960063,0.014597053,-0.038719244,0.015246595,-0.016414504,-0.03373843,-0.0456777,-0.069081046,-0.08549044,0.05661146,-0.043763164,-0.011961372,-0.01578443,-0.023128351,0.010968346,-0.012071341,0.12311443,0.046800327,0.0376421,-0.04378433,-0.047547616,-0.016990041,0.01797373,-0.07610943,-0.054718893,-0.079398185,-0.04011317,-0.02085893,0.0653919,-0.060403243,-0.00030889604,0.051578056,-0.045077395,-0.030871795,0.032995418,-0.026028017,0.033517454,-0.03638497,0.008522204,-0.016765703,-0.011171039,-0.02791378,0.061589707,-0.023571925,0.06943162,0.044065118,-0.11350498,-0.023475043,-0.0255452,0.024722124,0.010363587,0.03213092,-0.026780438,-0.09284887,-0.0552705,0.0016422174,-0.013276604,-0.022930603,-0.03684296,0.023578726,0.022699216,-0.063648544,0.040216345,-0.065633,-0.008669347,0.01972076,-0.045019474,-0.039004706,0.0023315004,0.04446274,0.00051553035,0.028349346,0.0540932,-0.0027794982,0.092560604,-0.02010333,-0.05296818,0.009575076,0.0030391256,0.09211761,0.03728703,0.08759613,-0.012671619,0.011417693,-0.038165204,0.09402222,0.034421083,0.063530505,-0.036800284,-0.025258187,-0.009628706,-0.036415275,0.053376205,-0.0038278177,0.012819079,-0.00961832,-0.027418805,0.0619962,-0.011146506,-0.042009942,-0.08186193,-0.06269293,-0.06423112,0.07174646,0.03324252,0.034771495,0.072620675,0.006337871,0.04167188,-0.0487251,0.03257297,0.08590703,0.022560762,-0.09064307,-0.023141138,0.004421144,0.063017584,-0.037652463,0.008530734,0.090075806,-0.067771934,0.007974568,-0.093988,4.152559e-34,0.06401645,0.062444728,0.025000393,0.036662567,-0.09221258,0.033314843,-0.07633851,-0.016737528,-0.026858514,-0.05456855,-0.075814046,-0.07948547,0.053464882,0.019983144,-0.025510313,-0.03555928,0.023103954,-0.0664292,0.06919381,-0.0108848,0.035810597,0.084112406,-0.006372142,0.015242614,0.022536382,0.033370633,-0.007867549,-0.0113400575,0.010661552,0.010073511,0.11049475,-0.07722613,-0.068080164,0.025995871,0.08044847,0.010838148,0.016367277,-0.0039665014,-0.05200211,0.047775097,0.01860306,0.08264404,0.005367018,-0.01813257,0.077808715,-0.09234984,-0.03336091,0.13629597,0.0440414,0.11051827,0.013981179,0.018015273,0.13773917,-0.0045182025,-0.056268323,0.057048023,-0.019579476,-0.020179164,0.046016797,0.053698316,0.008823486,0.044200428,-0.02842111,0.06366803,-0.0066277664,0.050323438,-0.051136825,0.0055848025,0.010343009,0.08823977,-0.06544412,0.020606328,0.01886957,0.037595365,0.006148518,-0.06224369,-0.096155904,-0.02661737,0.041699998,0.02488289,0.037356324,-0.03859738,0.032120705,-0.016781328,-0.070701376,-0.014658284,-0.046434585,0.033584032,-0.0039519877,0.007967606,0.09729295,-0.030984268,-0.043179058,-0.020349199,0.05397656,-2.2038715e-33,0.06693788,-0.10001538,-0.006221508,0.018948445,-0.06645196,0.07841925,0.025163447,-0.098166496,-0.010447428,-0.004718744,0.04947897,0.007392091,0.06282379,-0.0973455,0.013199664,0.014438442,-0.07810236,0.08272739,0.053935286,0.020380301,-0.057149727,0.117799975,0.008842385,-0.013044138,0.06479514,0.01790689,-0.06250542,0.059619665,-0.003142716,0.019143308,0.028189817,0.017136343,-0.07387906,-0.11086546,-0.056053117,-0.008017227,-0.035048008,0.016462248,0.018723786,0.012749803,-0.030093865,0.049785875,0.03434078,0.09156085,0.0006443968,0.017912814,-0.052349743,0.0662768,0.01950321,0.022381356,-0.007988735,-0.055436634,-0.055646762,-0.083780356,0.04057691,-0.00064301654,0.06327242,-0.016526558,0.009029893,0.033065237,-0.010234691,-0.06265264,0.07245565,-0.026441984,0.054223247,0.026394993,-0.020010909,0.14900531,0.029428288,0.028932137,0.016391082,0.035165526,0.032690585,-0.019373683,-0.029079696,0.012725257,-0.080331005,0.02344319,0.01673538,0.020410841,-0.029562483,0.034243606,0.035386436,-0.064612314,-0.013115721,-0.07765865,0.029878551,0.01204598,-0.045269527,0.01755795,-0.07702191,-0.050455462,-0.010883102,0.0038070653,0.009716758,-2.6747106e-08,-0.014903912,-0.07294643,0.052895162,-0.063543156,-0.005071653,0.044498563,0.018037593,-0.056193113,0.049953047,-0.09315083,-0.049067706,0.11069743,0.06794935,0.0344454,0.047148146,-0.0114231305,0.028361462,0.03599081,-0.063018784,-0.005045359,-0.08746732,-0.03943878,-0.16411099,0.047720224,0.031868413,-0.05773281,-0.020132758,0.037384864,0.052826285,-0.045672093,-0.07240598,0.012002744,-0.015614093,-0.06228113,-0.119858935,0.024540093,-0.046062123,-0.070739694,-0.033989556,-0.009134826,0.046887286,-0.013464242,-0.025192652,-0.007452671,-0.017456194,-0.008169861,0.006379802,-0.019242449,-0.061950237,-0.014525836,0.027662035,-0.00045054898,0.013035189,-0.0096074445,-0.07550952,0.052827924,0.048436902,-0.08339968,0.044211518,-0.044504818,0.00841517,-0.013142431,0.15507582,-0.027331397 +1.14.11.75,Requires Fe2+ and ascorbate. The enzyme has been characterized from the bacterium Pantoea ananatis.,384,1.0,-0.015481109,-0.03178541,-0.11070373,0.06925571,0.06960063,0.014597053,-0.038719244,0.015246595,-0.016414504,-0.03373843,-0.0456777,-0.069081046,-0.08549044,0.05661146,-0.043763164,-0.011961372,-0.01578443,-0.023128351,0.010968346,-0.012071341,0.12311443,0.046800327,0.0376421,-0.04378433,-0.047547616,-0.016990041,0.01797373,-0.07610943,-0.054718893,-0.079398185,-0.04011317,-0.02085893,0.0653919,-0.060403243,-0.00030889604,0.051578056,-0.045077395,-0.030871795,0.032995418,-0.026028017,0.033517454,-0.03638497,0.008522204,-0.016765703,-0.011171039,-0.02791378,0.061589707,-0.023571925,0.06943162,0.044065118,-0.11350498,-0.023475043,-0.0255452,0.024722124,0.010363587,0.03213092,-0.026780438,-0.09284887,-0.0552705,0.0016422174,-0.013276604,-0.022930603,-0.03684296,0.023578726,0.022699216,-0.063648544,0.040216345,-0.065633,-0.008669347,0.01972076,-0.045019474,-0.039004706,0.0023315004,0.04446274,0.00051553035,0.028349346,0.0540932,-0.0027794982,0.092560604,-0.02010333,-0.05296818,0.009575076,0.0030391256,0.09211761,0.03728703,0.08759613,-0.012671619,0.011417693,-0.038165204,0.09402222,0.034421083,0.063530505,-0.036800284,-0.025258187,-0.009628706,-0.036415275,0.053376205,-0.0038278177,0.012819079,-0.00961832,-0.027418805,0.0619962,-0.011146506,-0.042009942,-0.08186193,-0.06269293,-0.06423112,0.07174646,0.03324252,0.034771495,0.072620675,0.006337871,0.04167188,-0.0487251,0.03257297,0.08590703,0.022560762,-0.09064307,-0.023141138,0.004421144,0.063017584,-0.037652463,0.008530734,0.090075806,-0.067771934,0.007974568,-0.093988,4.152559e-34,0.06401645,0.062444728,0.025000393,0.036662567,-0.09221258,0.033314843,-0.07633851,-0.016737528,-0.026858514,-0.05456855,-0.075814046,-0.07948547,0.053464882,0.019983144,-0.025510313,-0.03555928,0.023103954,-0.0664292,0.06919381,-0.0108848,0.035810597,0.084112406,-0.006372142,0.015242614,0.022536382,0.033370633,-0.007867549,-0.0113400575,0.010661552,0.010073511,0.11049475,-0.07722613,-0.068080164,0.025995871,0.08044847,0.010838148,0.016367277,-0.0039665014,-0.05200211,0.047775097,0.01860306,0.08264404,0.005367018,-0.01813257,0.077808715,-0.09234984,-0.03336091,0.13629597,0.0440414,0.11051827,0.013981179,0.018015273,0.13773917,-0.0045182025,-0.056268323,0.057048023,-0.019579476,-0.020179164,0.046016797,0.053698316,0.008823486,0.044200428,-0.02842111,0.06366803,-0.0066277664,0.050323438,-0.051136825,0.0055848025,0.010343009,0.08823977,-0.06544412,0.020606328,0.01886957,0.037595365,0.006148518,-0.06224369,-0.096155904,-0.02661737,0.041699998,0.02488289,0.037356324,-0.03859738,0.032120705,-0.016781328,-0.070701376,-0.014658284,-0.046434585,0.033584032,-0.0039519877,0.007967606,0.09729295,-0.030984268,-0.043179058,-0.020349199,0.05397656,-2.2038715e-33,0.06693788,-0.10001538,-0.006221508,0.018948445,-0.06645196,0.07841925,0.025163447,-0.098166496,-0.010447428,-0.004718744,0.04947897,0.007392091,0.06282379,-0.0973455,0.013199664,0.014438442,-0.07810236,0.08272739,0.053935286,0.020380301,-0.057149727,0.117799975,0.008842385,-0.013044138,0.06479514,0.01790689,-0.06250542,0.059619665,-0.003142716,0.019143308,0.028189817,0.017136343,-0.07387906,-0.11086546,-0.056053117,-0.008017227,-0.035048008,0.016462248,0.018723786,0.012749803,-0.030093865,0.049785875,0.03434078,0.09156085,0.0006443968,0.017912814,-0.052349743,0.0662768,0.01950321,0.022381356,-0.007988735,-0.055436634,-0.055646762,-0.083780356,0.04057691,-0.00064301654,0.06327242,-0.016526558,0.009029893,0.033065237,-0.010234691,-0.06265264,0.07245565,-0.026441984,0.054223247,0.026394993,-0.020010909,0.14900531,0.029428288,0.028932137,0.016391082,0.035165526,0.032690585,-0.019373683,-0.029079696,0.012725257,-0.080331005,0.02344319,0.01673538,0.020410841,-0.029562483,0.034243606,0.035386436,-0.064612314,-0.013115721,-0.07765865,0.029878551,0.01204598,-0.045269527,0.01755795,-0.07702191,-0.050455462,-0.010883102,0.0038070653,0.009716758,-2.6747106e-08,-0.014903912,-0.07294643,0.052895162,-0.063543156,-0.005071653,0.044498563,0.018037593,-0.056193113,0.049953047,-0.09315083,-0.049067706,0.11069743,0.06794935,0.0344454,0.047148146,-0.0114231305,0.028361462,0.03599081,-0.063018784,-0.005045359,-0.08746732,-0.03943878,-0.16411099,0.047720224,0.031868413,-0.05773281,-0.020132758,0.037384864,0.052826285,-0.045672093,-0.07240598,0.012002744,-0.015614093,-0.06228113,-0.119858935,0.024540093,-0.046062123,-0.070739694,-0.033989556,-0.009134826,0.046887286,-0.013464242,-0.025192652,-0.007452671,-0.017456194,-0.008169861,0.006379802,-0.019242449,-0.061950237,-0.014525836,0.027662035,-0.00045054898,0.013035189,-0.0096074445,-0.07550952,0.052827924,0.048436902,-0.08339968,0.044211518,-0.044504818,0.00841517,-0.013142431,0.15507582,-0.027331397 +1.14.14.174,"A cytochrome P-450 (heme-thiolate) protein found in plants, where it is part of the biosynthesis pathway of the red naphthoquinone pigment shikonin.",384,0.99999994,-0.07403318,0.039019305,-0.07318558,-0.02101728,0.08959385,0.08677223,-0.0052318494,0.04306233,0.051347908,-0.035628792,0.05089414,-0.023484472,-0.0032743043,-0.01769894,-0.032884065,0.04246266,-0.1105111,0.057367247,-0.04875501,-0.09391572,-0.018867686,0.03287154,0.032130197,0.030517355,0.010567721,-0.06421126,0.04833219,0.05810179,-0.05191371,-0.036623888,-0.052123237,0.016984547,0.018739872,-0.02858174,-0.025987245,0.13916662,-0.05459833,-0.081605904,0.0032923839,-0.0038790982,0.047742113,-0.044968292,-0.025873227,-0.021536527,-0.022312127,0.027607663,-0.032092515,0.037526906,0.06845734,-0.07107717,-0.053493395,-0.023779033,-0.01004915,0.0012966171,0.016299931,-0.020835835,0.06750822,0.018840816,-0.036528967,0.0014401663,-0.010688282,0.02634927,-0.02009995,-0.011042549,-0.016602213,-0.03133904,-0.045354366,-0.023986936,0.0035913822,-0.043984894,-0.00821207,-0.09306519,0.0066413283,0.015870789,-0.06449758,0.104253344,-0.016245991,0.03202939,-0.024249628,-0.06185387,0.082640775,0.051833324,0.031120472,0.14535867,0.044578023,-0.00417555,-0.021828167,0.0582451,-0.071187556,0.008899139,0.02801441,0.02384022,-0.04515913,-0.015653929,-0.119065024,0.04032365,0.08568391,-0.024199463,0.041820962,-0.037134524,0.037794594,0.029541759,0.0012747445,-0.10969853,-0.057389047,-0.025164012,-0.072427414,0.06356835,0.04589151,-0.09899217,-0.0016488505,-0.046963587,-0.025507739,-0.051272783,0.0013188897,0.078863025,-0.0059947283,-0.011837073,-0.03971813,0.042583518,-0.0559915,0.052622754,0.021953255,0.072810054,-0.012600822,-0.03294831,-0.14574207,7.4176416e-34,0.11408428,0.042333506,0.006891214,0.008418123,-0.037923194,-0.032795932,-0.048194703,-0.015662778,-0.05807886,-0.06685548,-0.067450374,-0.055128995,-0.030010698,-0.073492594,-0.024819093,-0.028431308,-0.043012064,-0.019953538,0.0018991838,0.05073691,-0.09186971,0.0075843367,-0.06346025,-0.02828668,-0.00083780737,0.08334536,-0.022659812,-0.06457203,-0.025049284,-0.0013248294,-0.035892013,-0.036453974,-0.045592986,0.014026346,0.034437686,-0.047985863,0.024892736,-0.0321896,-0.052661836,0.031312775,-0.017627535,0.011495334,0.04455427,-0.05395585,0.020795075,-0.0009113385,-0.10038562,0.030324077,0.0155506,0.09084037,0.04480501,-0.0015976682,0.16125683,0.01115067,-0.09732591,-0.085507,0.004069497,0.006663333,0.009586794,0.092172585,0.062861726,0.033266783,-0.031572346,0.046495404,0.047654178,0.029611314,-0.04517256,-0.008193538,0.00297047,0.10268593,-0.009779689,-0.004201356,0.09196722,-0.023685712,0.051020417,-0.0011829045,-0.008288364,0.030978259,0.0040331325,0.054319628,0.0070737475,-0.01916049,-0.08205736,-0.06362505,-0.054852225,0.024091283,0.060475226,0.033954207,-0.060099117,0.017798355,0.03361239,-0.039285038,0.004020511,-0.030933086,-0.011420153,-2.3000442e-33,0.06976703,-0.054635793,-0.0072194175,-0.06795873,-0.047348764,0.01763452,-0.028332284,-0.023004072,-0.013590539,0.04992572,0.12889981,-0.046655297,0.021669904,0.04659415,-0.020093413,-0.0016614136,-0.042077776,0.107349254,0.0062672063,0.05856371,-0.07549765,-0.015949065,0.014733604,0.07746322,0.02871363,0.056003965,-0.0342441,-0.009095775,-0.024326375,0.014608742,-0.042343725,-0.021064218,-0.114378415,-0.016764548,0.0043962155,0.019851202,0.0137786595,0.0040940144,0.021267906,0.069208674,-0.0022653493,0.034123585,0.038175896,0.07048632,0.055660386,0.045981325,-0.051317763,0.058927376,-0.028408548,-0.014252287,0.03848287,0.037468243,0.03723973,0.042279575,-0.051300794,0.03248287,0.006749157,0.0641426,-0.021094197,0.03986889,-0.024738142,-0.061784223,-0.072171636,0.10602736,-0.030952249,0.073086746,-0.019302052,0.033188052,0.05170994,-0.035635445,0.04599151,0.023952119,0.1018543,0.11158141,-0.0109318355,-0.017705856,0.042234074,-0.008834436,0.004031093,0.044844553,0.004833136,0.020828275,-0.0278176,-0.062222734,0.007956934,-0.07693616,-0.04242049,0.048080385,0.006234878,-0.102984466,0.0068254056,0.09762218,-0.051192492,0.04224667,0.02196577,-2.9587925e-08,0.05158269,-0.08498105,0.01542599,-0.057688717,0.08139131,-0.028738221,0.019550715,-0.0039395634,0.030038496,0.031966493,0.02273688,0.05922687,-0.059895087,-0.04594644,0.039440047,0.019685723,0.075801685,0.038824998,0.05337028,0.052472115,-0.04354488,-0.017247535,-0.08354636,0.0058096997,-0.0036915883,-0.06666197,0.0004946338,0.010232395,0.04682596,-0.021681856,0.055397682,0.042726483,-0.07220376,-0.0061131683,0.039214585,0.017202886,-0.07714227,-0.052260395,-0.031861857,-0.016070683,-0.056637924,-0.021002807,-0.059675798,-0.03632341,-0.003211322,-0.028694144,0.06737466,-0.00074131024,0.0077419947,0.0035761355,-0.04731465,0.010819382,0.06562752,-0.099672616,-0.11909609,-0.006863481,0.11404924,-0.02203944,-0.012382155,-0.06791041,-0.03445393,0.017532207,0.18209422,0.013949582 +1.14.14.175,"A cytochrome P-450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant.",384,1.0,-0.0858161,0.0023137485,-0.11721334,0.019299489,0.056366988,0.10411104,-0.10813325,0.045065742,0.036639977,-0.07278551,0.028168742,-0.0028235824,-0.07816816,-0.029362021,-0.038508784,0.064550675,-0.05470422,0.0047059646,-0.022181323,-0.0271618,0.005033526,0.025599426,0.038053036,0.04159768,0.04069387,-0.013018077,0.05565705,0.0162565,-0.055232834,-0.012965111,0.0315116,0.00679302,0.089890026,-0.08037279,-0.0048493324,0.10670997,-0.065524094,-0.019406186,0.050990175,-0.009301758,0.03387461,-0.06171114,-0.08484814,-0.01145215,0.010829342,-0.05588887,-0.0129010575,0.039058328,0.04600681,-0.04419255,-0.053665906,-0.042157643,-0.07494675,0.015296982,-0.065959446,-0.016298829,0.029046342,-0.01841076,-0.05727852,0.05433457,0.017715357,0.025962032,-0.04555529,-0.013521995,-0.056513395,-0.020176595,-0.013008287,-0.04893385,0.008839218,-0.09191838,-0.020218125,-0.113973364,-0.09424172,0.022789666,-0.07711169,0.030084495,-0.021536684,0.021052076,-0.01738986,-0.06517772,0.06788444,0.037945177,-0.0030333367,0.10467069,0.06565235,0.057437427,-0.0010893259,0.04919936,0.0025360987,-0.0038335235,0.009825633,0.0025658407,-0.016157553,-0.022845464,-0.0973142,0.017860033,0.007181751,0.02654183,0.005267103,-0.023541965,0.052202836,0.0649303,-0.05096237,-0.1324076,-0.071221024,0.059017826,-0.048380546,0.013903037,0.051852122,-0.08784081,-0.04608703,-0.0008199307,-0.026028533,-0.0592161,-0.02393039,0.028539719,0.033753693,-0.038813647,-0.075942084,0.0068618027,-0.0027893574,-0.042370018,0.04959574,0.0110825375,0.023146894,0.028733645,-0.091374986,5.8648683e-33,0.06426205,0.017050765,-0.017211854,0.014943209,-0.024473147,-0.0101999305,-0.062111106,0.08308203,-0.0455081,-0.030843891,-0.06272128,-0.079795755,-0.023937121,-0.03146353,0.027217146,0.02244411,-0.00023280496,-0.018193834,0.07959833,-0.009299848,-0.06716153,0.040201228,-0.057159152,0.0013111155,-0.035786755,0.09146049,0.008282675,-0.017056465,0.02006649,-0.004490126,0.069970064,-0.091953225,-0.065371394,-0.042330604,0.021720514,0.016326396,-0.056326114,-0.053356133,-0.0626324,0.048629828,-0.049126636,0.055780448,0.04040905,-0.02215208,0.02109634,-0.01075518,-0.09639298,0.035022218,0.10213037,0.046788394,0.0027940331,0.008029475,0.18002374,0.09521319,-0.015440581,-0.012516944,0.021834433,0.07100149,-0.002265261,0.06471365,0.061869573,0.0012452365,-0.046046656,0.013178977,0.023737546,0.06223661,-0.059098564,0.026729727,-0.031279773,0.10305754,0.016378194,0.032197382,0.004502045,0.026410816,0.034499004,-0.019864343,0.020303288,0.021050906,0.033560164,-0.0034249872,-0.021845698,0.022763614,0.026616417,0.02873011,-0.04427012,-0.0031102372,-0.01381017,0.015929125,-0.036483772,0.05333938,0.0008691409,-0.035777207,-0.0256136,0.016155522,-0.008484439,-5.0323883e-33,0.058928818,-0.060878184,-0.0105241565,-0.10426776,-0.034889273,0.09706399,-0.04484094,0.009493943,-0.058311757,0.04701996,0.07136297,-0.038555343,0.02142529,-0.004997508,-0.009220275,0.009420452,0.003547338,0.07773279,-0.023867644,0.0019524385,-0.07026232,0.06581713,0.044873398,-0.002728803,0.03081585,0.04548462,0.017011618,0.030658362,0.022964107,0.010933398,0.010855837,-0.0022520085,-0.09773162,-0.032229215,-0.03409411,0.08981295,0.0148025,0.038262267,-0.012274949,0.08561841,-0.020304447,0.062316384,0.0068113687,0.022450794,0.054483626,0.019966563,-0.12550382,0.031118682,-0.060059827,-0.006486469,0.06774246,0.0053265477,0.031758808,0.04174604,0.03272889,-0.012497118,0.036381725,-0.032522913,-0.0010357605,-0.09915975,-0.02979356,0.0036165593,-0.040055875,0.066142306,0.004983444,0.064383976,-0.027045734,0.06935796,-0.0033064683,-0.0011376229,0.02163721,0.015050214,0.03779881,0.11243776,-0.045838125,0.04706334,0.048976585,-0.053661782,0.04160823,0.010182874,0.016593665,-0.03429176,-0.005603467,-0.059587885,-0.09314804,-0.08013376,-0.022064762,0.04620099,0.036159,-0.009966609,0.0044186534,0.09339399,-0.029830132,0.053559702,0.085135244,-4.160138e-08,0.03495033,-0.1072856,0.025557155,-0.040337086,0.011875062,-0.04622858,-0.001055205,0.0070031337,0.0018976369,0.02001302,-0.009662002,0.086206004,0.0050811945,-0.038121928,-0.006237242,0.0020207271,0.08021809,0.06843182,0.005723509,0.053667866,-0.0033524982,0.046432212,-0.086728476,-0.004077956,0.019268021,-0.1526879,-0.0046414495,-0.0015962117,0.047578465,0.028662553,0.053017743,0.031452045,0.031648457,-0.04204695,-0.01874249,0.02978842,-0.054308183,-0.07431754,-0.041049164,-0.01926111,0.0013250295,-0.09881776,-0.05711777,-0.016942443,0.031867657,-0.04425262,0.073598504,0.0024618546,0.013551307,-0.0102331815,-0.037533835,-0.019088045,0.047833733,-0.07804963,-0.12358461,-0.019267326,0.070463985,-0.0494131,0.014800062,-0.116764866,-0.020535346,0.068863906,0.2122038,0.021881478 +1.14.14.176,"This microsomal cytochrome-P-450 (heme-thiolate) enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.",384,0.99999994,-0.0070846295,0.035190903,-0.026550824,-0.022463072,-0.02998809,0.0062848316,0.037314843,0.09714164,0.055310037,0.042494226,0.0058440645,0.053314183,-0.028108513,-0.027572252,-0.029648436,0.052076634,-0.071868025,0.030502886,-0.0020282753,0.012594878,0.054698527,-0.01627552,0.061181158,0.0369381,-0.031924315,0.015738735,0.017606577,0.072294496,-0.023248326,-0.065723404,0.062276255,0.039258286,-0.0058732126,-0.020022096,0.023383994,0.054528896,-0.055787787,0.016603436,0.016323023,0.011862683,0.08294541,-0.070425406,-0.09029413,0.030200556,-0.062308412,-0.14246596,-0.07466016,-0.00011472203,0.080299266,0.07984224,-0.011769264,-0.036310226,-0.06944118,0.023798324,0.030879045,0.0126857,0.015895756,-0.005677926,-0.0028654523,-0.032029696,0.0006012457,0.041246332,-0.043509502,0.04574826,-0.029137582,0.03300018,0.0036655637,-0.052445658,-0.008213698,-0.06528942,-0.065876655,-0.07144899,-0.0008884155,-0.020466417,-0.05941094,0.002338647,0.011465491,0.026008185,0.0382698,-0.06703435,0.062041473,0.028275836,0.025654979,0.09065594,0.06272508,0.026230643,0.0570447,0.0009883245,0.09733084,-0.035208765,-0.023581605,0.08195954,-0.03780895,-0.018793954,-0.07985649,-0.015918672,0.035690557,-0.0035152712,-0.036301304,0.045358934,0.098660246,0.031486455,-0.07035675,-0.12086976,-0.055517767,-0.0047936854,-0.053372476,0.016403984,0.0108787315,-0.064803034,-0.03444566,-0.018177442,-0.006790235,0.050139006,-0.029318852,0.095388,-0.016009329,-0.06289635,-0.022215972,-0.119782716,-0.05405771,-0.046886712,-0.03457523,-0.02853782,-0.018659428,-0.049311373,0.0016877473,1.1061461e-33,0.035476275,0.03211539,0.030344624,0.0126846135,0.028839586,0.019080522,-0.044083457,0.017150095,-0.15963893,-0.043955628,-0.08366333,-0.074046746,-0.02602287,0.016789243,0.0045215245,-0.07009487,-0.02080382,0.07330562,0.077986285,-0.01080033,-0.05147334,0.069473915,-0.03625496,-0.036172867,-0.048279427,0.12865178,-0.051404167,-0.0037883557,0.04733815,0.016987804,-0.063660085,-0.018492527,-0.01563591,-0.028199572,-0.038275026,0.021586277,-0.04628135,-0.0027042862,-0.05365326,0.07171198,-0.03727026,-0.0019084332,0.043037232,-0.048032388,0.0012086922,-0.04273833,-0.03466163,0.03309151,0.058790904,0.0061194184,0.01220361,-0.016347315,0.07438179,0.0432726,-0.10971845,0.063702896,-0.056761835,0.017860388,-0.027958773,0.03754896,0.12546465,0.021619335,-0.04636978,0.05027121,0.009126154,0.06264611,-0.010602973,-0.05071065,0.040171243,0.123066,-0.06745873,0.05661314,0.113269545,0.01566964,0.04608994,0.017395133,0.024904637,0.06858739,0.0049890126,0.043662902,-0.058504146,-0.044679467,-0.012399205,-0.0055565755,-0.039418474,-0.017395804,0.03142818,0.022312287,-0.05555194,0.060015842,0.02422728,-0.11172948,-0.021854093,0.023132531,0.018022869,-2.8001954e-33,0.0392754,-0.09137483,0.07326125,-0.08233179,-0.05305777,0.09124043,-0.0034168495,-0.028795905,-0.019880177,0.08009372,0.080218375,0.008594824,0.058599796,-0.036808982,-0.021351492,-0.014233843,0.024370616,0.021787519,-0.043343082,-0.025738409,0.075347334,0.07748502,0.0252804,0.10117448,-0.012395069,-0.005871994,0.074306026,-0.018565625,0.007742808,0.044827204,0.01390565,0.04541591,-0.04353168,-0.0016539113,-0.0151780555,0.036065027,-0.017261025,0.010876332,-0.017296657,0.019455133,-0.115396276,0.019710721,0.005136523,0.014999551,0.063051835,0.03124227,-0.10530575,-0.016822759,-0.0005606028,-0.022359988,0.039893925,0.06972283,-0.0469451,0.0036570895,-0.0013455178,0.05190471,-0.038242385,-0.040188916,0.051092584,-0.035778355,-0.04915243,-0.0023358501,-0.0024853314,-0.01939718,0.036488328,0.054132603,-0.027910152,-0.017839434,0.0845028,-0.0030510386,0.085366175,0.06582264,-0.03239702,0.09035062,0.0040379437,0.022951005,0.020090587,-0.11305752,0.029883472,0.024399213,0.012046436,-0.04004466,0.003991582,-0.04501689,-0.12907557,-0.10605361,0.026508244,0.08494628,-0.0046503167,-0.02516225,0.007454099,0.034770317,-0.041609194,0.03759957,0.008876885,-3.6153622e-08,0.0018940467,-0.044900566,-0.028855506,0.02833936,-0.048426297,-0.006213846,-0.017355392,-0.011976674,0.046633393,-0.071580075,0.0042181937,0.05966298,-0.005395152,0.023038369,-0.020390011,0.06635128,0.009328513,0.026110759,-0.015187039,-0.033313606,-0.08001275,-0.013128688,-0.03005046,0.011528273,0.029436473,-0.11581154,0.008272425,0.042812362,0.0064572315,0.014291404,0.013545914,0.02321604,-0.11162238,0.010002477,-0.033119965,0.079396635,-0.032952253,-0.0170254,0.0363986,0.04536402,0.056700554,-0.13065797,-0.035839655,0.01650498,-0.021924397,0.01068377,0.014742945,-0.05096269,-0.006005079,-0.020033646,0.0062226215,0.055509806,-0.016793238,-0.10045263,-0.116934955,0.008733001,-0.021853177,-0.03987621,-0.018370148,-0.11359819,0.02998991,-0.013272043,0.2063681,0.010902424 +1.17.9.2,"Contains FAD. This enzyme, characterized from the bacterium Pseudomonas sp. SG-MS2, catalyses the incorporation of an oxygen atom originating from a water molecule into position C-6 of the lignan (+)-pinoresinol. The enzyme consists of a flavoprotein subunit and a c-type cytochrome subunit. Electrons that originate in the substrate are transferred via the FAD cofactor and the cytochrome subunit to the blue-copper protein azurin.",384,1.0,-0.0990389,-0.094353855,-0.09594638,0.020202218,0.14372575,0.04091511,-0.030827714,0.0476706,-0.008975654,-0.023966037,0.060056474,-0.051372062,-0.082908,0.022911789,-0.12373779,0.011182225,-0.09921998,-0.021501105,0.005236672,0.010228598,0.056191575,0.0026056434,0.0071304636,0.0016604275,0.032868553,0.03211702,0.065254085,-0.03464672,0.0060597113,0.01108996,0.03526822,-0.0126909055,0.0907131,-0.023754783,0.034321092,0.024406629,0.045709636,-0.045700498,0.036462095,-0.026960539,0.03931016,-3.597344e-05,0.045512296,0.013587784,0.06788694,0.010048735,0.024947241,0.02798975,-0.005742343,0.0076553193,-0.0130748125,-0.06065945,-0.1166099,0.07514721,-0.016432464,0.05510438,-0.008716653,-0.08170849,0.017480131,0.020644778,0.037602663,0.031709068,-0.0041499496,0.041081406,0.06864464,-0.031840853,-0.026093181,-0.020943604,0.053876318,-0.057934172,0.004847437,-0.053740747,-0.005693071,0.006381298,0.00910442,0.035005182,0.0071642483,-0.06291027,0.06032703,-0.03534155,0.026689889,-0.03983615,0.091390066,0.14901982,0.024789842,-0.06194525,0.06639314,0.003477229,-0.014307394,-0.005243957,-0.018343708,0.019299125,-0.06779101,-0.09094941,-0.073564716,0.055290826,0.04222848,-0.0062257596,0.02260981,-0.018760664,0.00016890714,0.08169197,0.048024036,-0.1083703,-0.051572323,-0.046614565,-0.047719803,0.13950829,0.013356163,-0.022453388,0.044235494,0.035235483,0.011380645,-0.07808049,0.012280037,0.020384667,0.033859234,-0.07572889,-0.042092185,0.025442488,-0.018999226,0.0030247762,0.020577248,0.07248843,0.03042949,-0.0042729704,-0.16585802,6.447081e-34,0.06383996,-0.0075639025,-0.037045296,-0.046195194,-0.030032411,0.0066971234,-0.076886214,-0.027949048,-0.048644625,-0.007858056,-0.05968315,-0.05339834,0.023667103,0.004417849,-0.0031445813,-0.02297218,-0.03104261,-0.050111547,0.078595825,-0.04406388,0.023484668,0.08627201,-0.033500154,-0.03797071,0.10995024,0.044254422,0.011851605,0.015393197,0.007000215,0.014377719,0.053410493,-0.06171861,-0.13508849,0.012554312,0.04776401,0.014369232,-0.03903092,-0.08358467,-0.031140074,0.03603011,0.06468626,0.0016495922,0.0343431,0.011934189,0.050044544,-0.055306498,-0.08312349,0.061970577,0.07402214,0.08159207,0.016166372,-0.057124343,0.054223735,0.07095141,-0.092851564,0.014781597,-0.07810941,0.010987974,0.042500194,-0.0008590965,0.06064024,0.05125905,-0.061648328,0.10515643,-0.013076461,0.014514245,-0.05230011,-0.047569785,0.063575566,0.111287385,-0.085825235,-0.039231215,0.07032943,-0.008114775,0.022475494,-0.059298612,-0.03487143,-0.021434803,0.0034066862,0.04854409,-0.055018548,-0.0675141,0.010773364,-0.039551158,-0.07295401,-0.008669499,-0.06533926,-0.07633937,-0.018792534,-0.026649473,0.028029487,-0.11207162,-0.027939485,0.033501778,-0.020595148,-1.910853e-33,0.05542073,-0.10528838,0.10529155,-0.06601362,-0.059786014,0.046663962,-0.005704149,-0.039039955,0.012535022,-0.017924378,0.06528516,0.026755469,0.01841339,-0.043458458,0.01145739,0.037544277,0.010657573,0.045879878,0.08329514,0.029440017,-0.025256064,0.04243538,0.030802544,0.030496884,0.060601052,0.026647516,0.007952334,0.012024382,0.044305675,0.03812798,0.002299484,0.06547851,-0.046436284,-0.030285317,-0.085402444,0.0014736791,0.0044121877,0.005994662,0.011446085,0.037262026,0.030151276,0.0021718915,0.009173749,0.061845917,0.048544955,0.06467367,-0.038331147,-0.0061662444,0.030142622,-0.0859975,0.0035859721,-0.01900934,-0.040585604,0.016667333,0.06066492,0.03401889,0.01600189,0.022895072,-0.0356875,-0.037566446,0.010980276,-0.13544409,0.026060428,-0.047457736,0.055802878,0.048870154,0.016168773,0.094838865,-0.03499917,-0.051974524,0.069113664,0.059589237,0.004156171,0.062324308,-0.04420991,-0.015063731,-0.033020444,0.014265068,0.050243344,0.0065837684,0.0783079,0.00864283,-0.0058080554,0.009673689,-0.021372652,-0.07523091,0.021629762,0.09097912,-0.0125193745,-0.020972533,-0.04182101,0.04933555,-0.007041953,-0.004991305,0.045744717,-4.1036753e-08,0.0022313693,-0.060415775,0.05574203,-0.045190237,0.038727622,0.08610546,-0.022158246,-0.013109286,-0.026145587,-0.04555825,-0.06783552,0.07772743,-0.055124536,-0.048799943,0.05667169,0.025374714,-0.052340634,0.009315466,-0.040863976,0.048116654,-0.056589417,0.007525952,-0.10010761,0.028110247,-0.078259535,-0.021224981,0.04705641,0.02689405,-0.0026752858,0.017683625,-0.017360419,0.014962737,0.0097179925,0.006785342,-0.115500025,0.014342237,0.03916273,-0.08314041,-0.043270625,0.019025456,0.018212218,-0.0040754634,-0.049724586,-0.039820492,-0.02777405,-0.015042113,0.03454522,-0.009910214,-0.05643593,0.025623525,0.074369565,-0.05131958,0.0066238395,-0.020029468,-0.07689061,-0.02257263,-0.01190348,-0.10001712,-0.011884095,0.01691232,0.014628753,0.036750484,0.16457616,0.019723646 +2.1.1.366,"The enzyme methylates only dimethylated lysine9 of histone H3 (H3K9), forming the trimethylated form. This modification influences the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. The enzyme is highly upregulated in Huntington disease patients. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, and EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.",384,0.99999994,-0.016803794,-0.034764662,-0.04642407,-0.0862947,0.010070078,0.0827179,-0.06787544,0.035130255,-0.104740255,-0.031855576,0.019879596,0.016476735,-0.038503744,-0.0036319413,-0.0091218455,0.08961069,-0.1291731,0.005442243,-0.045607172,-0.10769361,0.00642098,0.07748007,-0.0023785075,0.0032340635,-0.005414884,-0.051133424,0.11971938,-0.024654282,0.054211453,-0.025583537,-0.010983609,-0.041132987,0.047548797,-0.05593876,0.020472577,0.015886698,-0.019268673,-0.05675644,-0.02365584,-0.015342161,0.066318646,0.03158522,-0.028383682,0.049484026,-0.07194241,-0.06069741,0.03893708,-0.046746112,-0.018045783,0.050034005,0.021665603,-0.04939334,0.09743576,-0.013430854,-0.03418066,0.049979433,0.018070607,0.008614135,0.052509815,0.026243616,-0.016133772,-0.007737609,0.0059987707,-0.0732436,0.10939403,0.0332555,0.072481416,-0.07378927,-0.054192767,-0.0443064,-0.009947942,-0.045305815,-0.021343945,0.00879225,0.015530815,-0.038477708,-0.005803653,0.049540907,0.04607399,-0.019260595,-0.05991478,-0.028438112,0.08799169,0.046830285,0.002869549,-0.0059335185,-0.09587487,0.0652658,-0.016705837,0.0525345,-0.059319552,-0.14058916,-0.007707248,-0.038646817,-0.052310552,0.07443247,0.033899132,0.019270401,-0.0125145195,-0.03949112,0.05032408,0.0651884,-0.088135704,-0.00043428547,-0.009950808,0.10421091,-0.012524122,0.040791314,-0.03694016,0.012298353,-0.03730462,0.011334444,0.032974564,0.045367427,-0.08226123,0.036208533,0.010993314,-0.034139827,0.027508562,0.039917607,0.052865956,0.09207558,0.071118765,0.034043446,-0.007150492,-0.028698245,-0.09352617,3.5850484e-33,0.019743701,0.044381455,-0.097489886,-0.04114845,-0.0092076305,-0.04838391,-0.060404256,0.048055172,0.011890337,-0.096914954,0.014236237,-0.08325476,0.09233504,0.02232218,-0.08300581,0.028372828,-0.005879429,0.022713035,-0.010402657,-0.012698597,-0.03521596,0.015945744,-0.026571115,0.026930267,-0.012936329,-0.035986844,-0.028314505,0.091197774,0.025808068,-0.0014037482,-0.038974382,-0.06377819,0.028300123,0.0020139748,0.08742378,0.10544099,-0.0082683535,-0.0016573025,-0.023166977,0.08959207,0.04483293,0.01959617,-0.03568441,-0.0659517,0.0061989445,-0.0382326,-0.011976332,-0.043890473,-0.08543121,-0.023572112,0.023095408,-0.021697303,0.069113344,-0.025148686,0.006404166,-0.06598636,0.015484973,-0.04173139,0.028526504,-0.014675941,0.021639548,-0.02961203,0.0050474834,0.08789558,0.021480463,-0.04311419,-0.031020146,-0.027345527,-0.03185629,-0.019664561,-0.020708151,-0.01084102,0.059053242,-0.017137801,-0.027194984,-0.053496335,-0.09520879,0.010236808,-0.03374939,0.021586346,0.027469788,-0.03560467,-0.041758005,-0.04172196,0.0014393495,-0.057017464,0.015405447,-0.07508629,-0.041777812,-0.032694336,0.023495883,-0.074715644,0.036699038,0.013131053,0.050886173,-5.4374897e-33,-0.0618898,0.06454921,0.056248378,-0.065095894,-0.0066796904,0.055406276,0.076640755,0.017561948,-0.012639651,-0.08479365,0.0491657,-0.018860582,-0.041539077,-0.1075247,0.025938326,0.062046222,0.013708128,0.0825906,-0.008233662,-0.06081273,0.033115573,0.029690811,-0.096002035,0.124674976,-0.020416614,-0.01962202,-0.092483886,0.07964751,0.088922635,0.09167043,-0.10247126,-0.01313878,0.01003393,0.015953232,0.02409056,0.0068807653,0.014142423,0.041737385,0.006911041,-0.018074088,0.05346874,0.04984264,0.011805215,0.04758494,0.01509652,0.122856386,-0.04888444,0.033293672,-0.014485417,0.005457258,0.037645426,0.013344261,0.0174103,0.0906929,0.021030022,0.018185096,0.07298936,-0.013653527,-0.010720347,-0.0072367475,-0.10532016,0.025202008,-0.015209378,0.09463407,0.001989008,-0.038634762,-0.065036766,0.050089512,0.014156513,-0.001798006,-0.030960422,0.037374657,0.080582395,0.050351862,-0.043606073,-0.071682185,-0.061918013,-0.014347999,-0.032792963,-0.024692962,0.013066678,-0.07203777,0.053527523,-0.004860741,0.05437848,-0.0418753,0.010936113,0.07956986,0.022925332,-0.049767073,0.017391177,0.01145063,-0.13055259,0.030649483,0.0012938355,-4.7770378e-08,0.07313575,-0.1268421,-0.03129512,-0.010677054,-0.01775385,0.050478302,-0.02574898,0.07059427,0.008939961,0.042723656,0.021061748,0.051938366,-0.074392185,-0.019728731,-0.023130111,-0.035980325,0.020410407,0.08032613,0.008441293,-0.037967548,-0.0798322,-0.03095012,0.043263268,-0.00046708525,0.04313633,-0.0052895606,-0.05558567,0.09060419,0.0817691,-0.07175409,0.008796122,0.039153077,0.008760538,-0.05853393,-0.0943035,0.0005231918,0.11571433,-0.03105609,0.06233172,0.062411055,0.02884814,0.05135002,-0.07280861,0.010343365,0.067907736,-0.036387574,0.05088676,0.046670362,0.0058696433,-0.07476639,0.0072903954,0.0034156062,0.046743203,-0.060191344,-0.021760505,-0.002082529,-0.06861627,-0.01679211,0.006839406,-0.04399606,0.054394696,0.033805232,0.11227233,-0.080860406 +2.1.1.367,"This entry describes several enzymes that methylate the L-lysine-9 residue of histone H3 (H3K9) only once, generating a monomethylated form. These modifications influence the binding of chromatin-associated proteins. cf. EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase, and EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase.",384,1.0,0.003736801,-0.012464068,-0.11177494,-0.08932727,0.06753059,0.10751525,-0.06378837,0.025416216,-0.051734153,-0.08264042,-0.0039812634,-0.0054776464,-0.050636403,0.003967986,0.04034563,0.05672655,-0.16102701,-0.010597263,-0.055683456,-0.09621933,0.032475974,0.11436986,-0.015983602,-0.045723032,0.049314015,-0.08466596,0.021525314,0.013432256,0.08556519,-0.039728135,-0.014624572,-0.04762956,0.014978841,-0.0034332273,0.08107561,0.04559967,-0.0037415533,-0.043793213,0.04195955,0.03635066,0.08427674,0.0153285125,-0.047355507,-0.0062236623,-0.06938763,0.025629904,0.028051052,-0.019341413,-0.030702425,0.0072694346,0.018218802,-0.0308824,0.028815335,-0.019799665,-0.070982195,-0.047988072,0.0067055305,-0.024887897,0.02615113,-0.004095795,-0.031329483,0.021586632,0.047500767,-0.0022861336,0.09058921,-0.05756437,0.051943857,-0.06789868,0.015896888,-0.010595685,-0.033744168,-0.06769437,-0.030312356,0.009029735,-0.0087592965,-0.018913567,-0.0017849861,0.06706717,-0.03178688,-0.038422555,-0.022825206,0.021847297,0.039365202,0.05637675,-0.016995596,-0.044732068,-0.10984087,0.083549745,0.043094605,0.04977809,-0.030433066,-0.068758085,-0.0026876703,-0.011419817,-0.038916446,0.09782608,0.057891637,0.022296203,-0.00070524757,-0.017539112,0.043720104,0.025965963,-0.120471425,0.06756445,0.079203255,0.06389998,-0.015511643,0.07700153,-0.05059758,-0.03594611,0.029185653,0.045993283,0.027893728,-0.015518374,-0.023129292,0.041388024,-0.0080238525,-0.01730416,0.0037421552,0.022019038,0.0333468,0.047558617,0.06718215,0.036328956,-0.06579821,-0.0025495577,-0.13439451,3.6173264e-33,0.016743576,0.07131979,-0.010711278,-0.035537604,-0.020460643,-0.055287994,-0.09489408,0.056408025,-0.012226051,-0.06608432,0.012503103,-0.021337772,0.06976118,0.004908235,-0.10689094,0.003155275,0.010964336,0.013635296,-0.0125044,-0.05287596,-0.05645513,-0.019910049,-0.026346797,0.03960964,-0.01255073,0.020833032,0.024989849,0.04795487,0.08404036,-0.023098186,-0.061795466,-0.06767142,0.066906646,0.016310845,0.08079799,0.058058497,0.028041733,-0.013848608,0.023860391,0.072675645,0.07283328,0.010292611,-0.04331575,-0.081850514,0.018653143,-0.033027634,-0.038653277,0.039093558,-0.06446787,-0.0011581223,0.015529502,-0.03129475,0.090792246,-0.06102656,-0.03367848,-0.03184124,-0.0016936334,-0.019425634,0.0019848247,0.049842007,-0.05390732,-0.03560447,0.0020064816,0.08332901,0.030933348,-0.025108181,-0.03276904,-0.0046264357,-0.022581777,-0.022308983,-0.047648795,-0.020390987,0.12057235,-0.008090282,0.058674157,-0.052938476,-0.0962776,-0.016518207,-0.013283159,0.07612471,0.06612433,0.048545767,-0.060440764,-0.082223274,-0.046544466,-0.04353729,0.04208465,-0.1356191,0.015983282,-0.0069660456,-0.012788311,-0.078801185,0.04235515,0.0032228262,-0.012209174,-5.7740143e-33,0.01850165,-0.012727085,0.030020304,-0.06788311,0.015382496,-0.004433717,0.06273101,0.01635973,-0.03954522,-0.038873,0.06871885,-0.04600974,-0.0052976245,-0.13154198,0.017940845,0.046657816,0.041024446,0.105136015,0.00013816175,0.008772654,0.0075958697,0.015178234,-0.044456914,0.10471943,-0.02383041,0.006043279,-0.067702204,0.07927022,0.07817242,0.041553795,-0.07828747,-0.021199618,-0.013831778,-0.0010515301,0.04940754,0.0068606227,-0.030133713,0.0159915,0.009011879,-0.024953596,0.04668126,0.0036997613,0.015552449,0.042454507,0.009965607,0.14649482,-0.07498775,0.061337613,-0.02441199,-0.051903043,0.010558564,-0.024450347,-0.037288398,0.07738414,0.03575234,0.051625628,0.07694904,0.044885363,0.01878809,0.024329344,-0.053371087,0.007484473,-0.024192207,0.09355484,0.0022717484,0.006061581,-0.055615883,0.011831298,0.022192694,0.04432247,0.030754026,0.025874566,0.050958354,-0.0021472862,-0.056020077,0.00014599401,-0.0651564,-0.0818914,-0.10067645,-0.052699942,0.03059089,-0.06719748,0.021617135,-0.020800987,0.014930508,-0.051376306,0.008044251,0.10752859,0.004475539,-0.005968187,0.015423661,-0.002193872,-0.09110814,0.057452258,0.0557765,-4.911616e-08,0.05456116,-0.118066594,0.033236615,-0.037140343,-0.032517947,0.037471782,-0.004394651,0.015092037,0.038308922,0.030545853,0.022658603,-0.032637052,-0.071946695,-0.08347225,-0.05074364,-0.053214453,0.019461744,0.09005274,0.009154857,-0.030351873,-0.05196451,0.021857677,0.05420175,-0.040667884,0.017826252,0.03653442,-0.06433449,0.07462953,0.10225564,-0.07487491,0.055019245,0.029502856,0.011398926,-0.04024404,-0.06668414,-0.017041871,0.070122816,-0.06261116,0.032199945,0.034423497,0.0493668,0.023740012,-0.103487015,0.012207294,0.021441111,1.7264158e-05,-0.056915227,0.048734903,-0.014655103,-0.022070207,0.018053176,-0.021501444,-0.0164658,-0.088252395,-0.04803591,-0.0035813472,-0.070850745,-0.006075447,-0.008273534,-0.027923964,-0.0020223632,0.04571257,0.13790584,-0.064204074 +2.1.1.368,"This entry describes several enzymes, characterized from plants, that successively methylate the L-lysine-9 residue of histone H3 (H3K9) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.",384,1.0,-0.03901597,0.04263205,-0.099802054,-0.05962067,0.072536625,0.1337255,-0.070464216,0.020762056,-0.029898794,-0.068245,0.025669651,-0.011186737,-0.04123912,-0.052865844,0.031602114,0.055094793,-0.15518034,0.03699807,-0.073711835,-0.116701715,0.034782767,0.12890539,-0.010189926,-0.03366565,0.043909796,-0.08680128,0.016061358,0.0067132083,0.057272237,-0.04446928,-0.021584453,-0.026158558,0.0382828,-0.014759154,0.054185864,0.039808888,0.00067529664,-0.08854781,0.05101178,0.027841093,0.08694881,0.031111967,-0.038825296,-0.0073824027,-0.06693408,0.041485965,0.016762502,-0.014883027,-0.033993226,-0.037953988,-0.0068710293,-0.04843484,0.044790022,-0.04920304,-0.0552593,-0.044395365,0.025691513,0.023328291,0.062494595,-0.023952583,-0.002002525,-0.024762224,0.027065895,-0.018410698,0.0686563,-0.054197468,0.0035969045,-0.054034315,0.02636174,-0.02328452,-0.029082563,-0.059615944,-0.0421482,0.020135965,-0.01796292,0.023634197,-0.0015143885,0.071854256,-0.0033222917,-0.045025866,-0.018534614,0.00827597,0.05356217,0.023348313,-0.031951405,-0.03437737,-0.08027131,0.094704136,0.044310857,0.05220924,-0.013490729,-0.101316966,0.01976066,0.017360186,-0.03676081,0.111351565,0.07116877,-0.0073472657,-0.02297318,-0.019102925,0.055130314,0.035744824,-0.118715346,0.047052022,0.07574025,0.090191394,-0.036365103,0.04059649,-0.02692731,-0.019154282,-0.0010063701,0.024745807,0.019286994,0.003039916,-0.05426338,0.036293477,0.0037596433,-0.027268395,-0.00995168,-0.009588222,0.030880114,0.030126084,0.049152426,0.02608038,-0.039927427,-0.00900104,-0.14263429,3.3767398e-33,0.012849499,0.072980314,-0.055486713,-0.017233195,0.006377923,-0.07864399,-0.07519024,0.02958182,-0.0067330883,-0.06030875,-0.008114556,-0.050541084,0.061620004,0.0075342786,-0.09441595,-0.018504456,-0.013292416,0.013042445,0.0019351344,-0.02676294,-0.0682503,-0.024714217,-0.050496794,0.037763,-0.022817135,-0.011258964,0.035446472,0.0139764715,0.06279538,-0.035426755,-0.033150073,-0.07525568,0.08482207,0.032453537,0.09143854,0.042517956,0.009051878,-0.05608793,0.013649158,0.08883636,0.05097756,0.02225725,-0.02007621,-0.0615455,0.02154318,-0.011956348,-0.030200573,0.024386354,-0.06625916,0.012024173,0.014984537,0.010460795,0.10143358,-0.024108047,-0.007045099,-0.045082323,-0.0068450226,-0.0061437837,0.01388073,0.02495349,-0.05408851,-0.05133973,0.007682359,0.09435464,0.037460618,-0.023256809,-0.06886162,-0.026163336,-0.0080058575,0.027723817,-0.02556797,-0.052735854,0.11847111,0.00025630184,0.043319505,-0.04965603,-0.10476975,0.013074828,-0.04336697,0.06441643,0.06913273,0.03147035,-0.04446431,-0.082934126,-0.055264704,-0.056383405,0.00058432255,-0.10510757,0.0069111357,-0.008932269,0.026785906,-0.0246222,0.047799364,0.0020938802,0.018177163,-4.7558555e-33,0.00779382,0.041918565,0.021759266,-0.048347715,0.018082524,-0.0027899758,0.03620671,0.0061597726,-0.025246779,-0.0677437,0.03985674,-0.03015403,0.011409332,-0.11215692,0.009020738,0.026549278,0.051581316,0.11215438,-0.04344595,0.0026016089,-0.02090207,0.011417174,-0.0811454,0.12402021,-0.037355423,-0.0030819545,-0.067489125,0.09749808,0.053939197,0.041237656,-0.043585945,-0.014726061,-0.019461146,0.020930076,0.041885324,-0.0010851973,-0.02155042,0.024301535,0.008213312,-0.005373746,0.028778318,0.009418053,0.0026166774,0.052360404,0.016825592,0.123990566,-0.04662585,0.09323269,-0.028512958,-0.015647314,0.006704519,-0.0083516585,-0.014922647,0.10003708,0.060248077,0.031646848,0.08685374,0.024244985,-0.011400398,0.048077874,-0.030630818,0.003098426,0.017307714,0.09423903,-0.005402998,0.051268637,-0.07171844,0.042898335,0.03163183,0.059501406,0.029667543,0.029598145,0.064630404,0.011612853,-0.06390742,-0.01934965,-0.0624648,-0.055847637,-0.11404115,-0.03447768,0.01910247,-0.0652251,0.037508003,-0.029436242,0.004365136,-0.03985103,-0.0048671174,0.10304498,0.006248406,-0.0058534965,0.016872285,-0.035952248,-0.09472442,0.057777267,0.0753548,-4.6767852e-08,0.012215366,-0.1392229,0.020081358,-0.020778978,-0.025663845,0.022901233,-0.004272017,0.03199428,0.044229448,0.034603067,-0.0027674285,-0.01776205,-0.066668846,-0.0650681,-0.007852363,-0.06015905,0.053941578,0.093563,-0.0026936566,-0.02153032,-0.07301444,0.009830918,0.035380017,-0.022829577,0.043917924,0.008291101,-0.048967697,0.1036914,0.12205209,-0.05841194,0.09108074,0.02023294,0.019704452,-0.047476754,-0.07592678,-0.010755791,0.076337926,-0.06559603,0.0725701,0.050270014,0.042914893,0.032031834,-0.098760284,0.021328786,-0.015113071,-0.023303725,-0.028707566,0.03892644,-0.025564946,-0.041407663,0.023527402,-0.00845054,0.013867442,-0.110899135,-0.02431278,-0.017587828,-0.064066835,-0.012280913,0.0030730776,0.00401213,-0.0132511975,0.02424259,0.11778912,-0.07186356 +2.1.1.369,"This entry describes enzymes that methylate the L-lysine-27 residue of histone H3 only once, generating a monomethylated form. This modification influences the binding of chromatin-associated proteins. The methylation of lysine-27 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.371, [histone H3]-lysine27 N-dimethyltransferase, and EC 2.1.1.356, [histone H3]-lysine27 N-trimethyltransferase.",384,1.0,-0.010501602,0.0014242035,-0.09495784,-0.03766595,0.035141725,0.09713059,-0.052798454,-0.032352876,-0.03488612,-0.027095962,0.01447416,-0.036006246,-0.012179682,-0.024796726,0.048889115,0.051441245,-0.17840742,0.0026030194,-0.045308474,-0.11126957,0.028874682,0.092493266,0.0038138314,-0.013284322,0.01976529,-0.050425563,0.008159881,0.012771804,0.07487908,-0.06531489,0.02523866,-0.053805556,0.040278126,-0.021884045,0.07146285,0.020093406,-0.021384234,-0.037253555,0.08339324,0.05901788,0.04676952,-0.010113137,-0.049919583,-0.017653205,-0.0739427,-0.029195234,-0.00065302907,-0.010873346,-0.05415864,0.0077374647,0.024061598,-0.06323158,0.035478186,-0.027511036,-0.04849006,-0.0043602246,-0.017074062,0.009039199,0.06104648,-9.088087e-05,0.0005094927,-0.033257633,0.010025255,-0.025255302,0.060502477,-0.116232045,0.051472552,-0.06448416,0.033867836,-0.013393186,-0.024375902,-0.059284966,-0.0021578432,0.036172032,0.032939166,-0.026209723,-0.0048984634,0.03769379,-0.021636136,-0.04115675,-0.041642148,-0.026659453,0.0363969,0.043706838,0.015856804,-0.0788207,-0.052014984,0.07927585,0.076405965,0.08186993,-0.02884229,-0.078209475,0.009161418,0.01808076,-0.031025467,0.08471838,0.077402055,0.003857949,-0.01983362,1.5297292e-05,0.046802692,0.028765475,-0.09961809,0.08603636,0.03791372,0.053459868,-0.0032457921,0.049027726,-0.05881184,0.0018093725,0.04424532,0.023321323,0.044698182,-0.0065488922,-0.019389128,0.084617056,-0.020718375,-0.007676068,0.027973613,-0.0042635673,0.012693292,0.031165779,0.054089226,0.042691205,-0.094586514,-0.017463055,-0.14496225,2.8067822e-33,0.052878782,0.06282063,-0.056482483,-0.007948391,-0.02007074,-0.019668246,-0.06401722,0.041122295,0.005144539,-0.07755091,0.043428034,-0.04142706,0.099437855,0.018924683,-0.09383303,0.009868067,-0.015064518,-0.013150128,-0.013883911,-0.061596416,-0.0461601,-0.03196608,-0.057982992,-0.0010884192,-0.025550427,-0.048822228,0.012693583,0.053184293,0.06700337,0.013336906,-0.06808657,-0.07465404,0.07771114,0.036602337,0.087035686,0.002723287,0.0037829154,-0.020446556,0.01709392,0.08909989,0.062523745,0.016695308,-0.027376352,-0.06806318,0.019902354,-0.015918795,0.009987544,0.06877611,-0.09216152,0.037482765,0.04869946,-0.008930741,0.043289084,-0.055979412,-0.017050417,0.028928474,-0.025432264,-0.04173298,0.016161695,0.049798664,-0.023118597,-0.036328968,0.061348166,0.095604554,0.080728285,-0.010810225,-0.029343462,-0.013502715,-0.065040536,0.02636127,-0.082804486,-0.0054852227,0.114060156,-0.03015854,0.007560958,-0.05856021,-0.1398594,0.002897338,-0.029935988,0.040753588,0.043147773,0.02882983,-0.08025026,-0.066953495,-0.040593024,-0.036955915,0.003135019,-0.14133003,0.025752235,-0.021515679,-0.0022052643,-0.10414332,0.031495936,0.03459382,0.020553466,-4.637908e-33,-0.013379269,0.038176455,0.04976997,-0.07511501,0.013064938,-0.02812254,0.07903362,0.037418686,-0.029774573,-0.040350653,0.053575534,-0.0045416886,-0.033471752,-0.10708469,-0.009700606,0.029755032,0.030632278,0.081032686,-0.042689346,0.0022695418,-0.006226049,-0.0024464503,-0.08482647,0.1291088,-0.05234629,0.028019713,-0.06308045,0.04962104,0.08933669,0.056493178,-0.055945605,-0.0056581628,0.0063135056,-0.023086049,0.031005321,0.03446309,-0.03893671,-0.006609177,0.0062754285,-0.041180324,0.001220641,-0.043417968,0.021295043,0.046812415,0.007764755,0.11677917,-0.0078238575,0.045470264,-0.007724197,-0.072442524,-0.03133892,-0.03222846,-0.01949877,0.07608047,0.020450268,-0.012776925,0.06571622,0.026663372,0.022983847,0.055614002,-0.006501347,0.016322067,0.0065972754,0.07471992,-0.014669728,-0.0030367584,-0.09781341,0.017921928,0.06497508,0.106565334,0.047507662,0.01343723,0.022483999,-0.0007127432,-0.063475095,-0.041015808,-0.036905054,-0.06833006,-0.11784444,-0.035231926,0.045601074,-0.059785046,0.010339931,-0.057901777,0.023329295,-0.047359347,-0.013241275,0.059606288,-0.017910538,0.04061688,0.005778286,-0.02366859,-0.099912636,0.073305346,0.02771637,-4.3226375e-08,0.0122016,-0.11699781,0.002060646,0.017671766,-0.030273166,0.071610875,-0.011420197,0.044283126,0.035365384,0.018830117,-0.027805803,-0.029744621,0.014349432,-0.037546284,-0.03320325,-0.013386075,0.032966446,0.09159738,-0.006627667,-0.061804935,-0.0056485003,-0.017971415,0.07318747,-0.007824072,0.011341301,-0.0029035802,-0.037570663,0.13892022,0.05944196,-0.06625104,0.06764395,-0.0050562844,0.052926973,-0.023321344,-0.062351797,0.011399892,0.056870002,-0.091040716,0.028007163,0.029959602,0.052368026,0.062438566,-0.1251239,0.019534262,0.036563843,-0.0014348613,-0.052123573,0.050190527,-0.007715993,-0.0016369758,-0.011485155,-0.016658634,0.027882388,-0.04106935,-0.024206655,0.018093994,-0.09616214,-0.0039334786,0.007613217,-0.018672103,0.025282092,0.017164188,0.1306027,-0.07611502 +2.1.1.370,"This entry describes enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. The human NSD3 protein also catalyses the activity of EC 2.1.1.hq, [histone H3]-lysine27 N-dimethyltransferase. cf. EC 2.1.1.364, [histone H3]-lysine4 N-methyltransferase, and EC 2.1.1.354, [histone H3]-lysine4 N-trimethyltransferase.",384,0.99999994,0.020230256,0.006129408,-0.07873816,-0.061446678,0.036350615,0.07501642,-0.056589592,-0.01990859,-0.0028934644,-0.032652967,0.0048424336,-0.0268583,-0.047417045,0.014665941,0.044451244,0.07192576,-0.14027572,0.039476458,-0.08024255,-0.10491696,0.030078452,0.11532222,0.012513201,-0.047512986,0.0054706857,-0.03875291,0.047460087,-0.022718199,0.09430128,-0.026532035,0.053280402,-0.065548606,0.060007907,-0.044523995,0.12056692,0.02998121,0.019789897,-0.02253941,0.004015818,0.009689585,0.08879541,0.00097552344,-0.041100804,0.021849645,-0.049194712,0.034592927,0.00269525,-0.034680415,0.0062831324,-0.005790551,0.028727653,-0.042404696,0.019844318,-0.030340659,-0.04712436,-0.0047673285,-0.07476053,-0.030598866,0.05068968,0.015001136,0.037103362,0.00073624786,0.055040423,-0.019787088,0.11813451,-0.07068518,0.07375246,-0.06273552,0.03275306,-0.035615876,-0.045936663,-0.07781478,0.00931811,0.054142457,0.033342216,-0.051395807,0.010216338,0.018646747,-0.026302908,-0.08826949,-0.020911116,0.030729212,0.08539141,0.035368346,0.010610446,-0.012747743,-0.06959037,0.03942922,0.018468576,0.06311884,-0.042616554,-0.08515525,-0.007487214,0.02540628,-0.038870446,0.08060439,0.04176158,0.074910216,0.0017629628,0.0029034438,0.036092013,0.07578538,-0.15004271,0.03107997,0.055484194,0.061600655,-0.0055221976,0.08559835,-0.056496337,0.0061430302,0.051215004,0.012058292,0.014779663,0.032137178,-0.006934896,0.059691634,-0.020398172,-0.03941393,-0.0063996306,-0.014969359,0.033915948,0.046832416,0.05127534,0.056232993,-0.055517383,0.013762132,-0.10308393,3.239678e-33,0.017922053,0.08633984,-0.0083895335,0.006690658,-0.056807585,-0.046822608,-0.09985413,0.029611107,0.019666918,-0.06961374,0.01969971,-0.019487547,0.096802235,0.017976768,-0.08255052,-0.0086042145,0.00854765,0.0031098884,0.022524241,-0.02935145,-0.049950246,-0.009999743,-0.0067315847,0.05901925,0.0011721774,-0.015423894,0.008105099,0.020128582,0.11717549,-0.0003607858,-0.071278885,-0.0801534,0.036598235,0.011423936,0.0053847567,0.064039394,0.028373936,-0.014446826,-0.008172241,0.10183499,0.021940883,0.018012123,-0.037525963,-0.09272102,-0.03894754,-0.01697148,-0.02387837,0.040473063,-0.0399169,-0.00439297,0.019814147,-0.040729254,0.10805762,-0.07106269,-0.039905153,-0.030975804,-0.03643376,-0.07392922,0.018540785,0.02612315,-0.06159394,-0.0130500775,0.0051416946,0.08170597,0.033507083,-0.045458943,-0.029087935,-0.044983357,-0.060048617,-0.011842514,-0.07665631,0.025248438,0.14903866,0.011397482,0.051864892,-0.08759077,-0.12144991,-0.026749074,-0.028534306,0.07773603,0.04700269,0.039647054,-0.03675209,-0.09198603,0.0027773615,-0.079173855,0.0016758941,-0.10380472,0.018840443,0.014385936,-0.02809159,-0.0967799,0.0172106,0.025633525,-0.005129334,-4.5483296e-33,0.013527818,0.015400792,0.008730631,-0.032207243,0.0012132166,0.017206162,0.06384407,0.06911892,-0.025207486,-0.026549928,0.08045494,-0.0502773,0.042949516,-0.10391458,0.037532233,0.024624985,-0.0035028195,0.03676701,-0.0041562063,-0.011422693,0.022412352,0.007576311,-0.07810775,0.119326256,-0.015117021,0.05635866,-0.060448237,0.0321836,0.06929936,0.06614355,-0.05426314,-0.00447154,-0.049449157,-0.023381632,0.022728419,0.038864832,-0.031952806,0.01647869,-0.025348453,-0.02642637,-0.025926445,0.052695412,0.025402328,0.06240418,0.021004502,0.14706543,-0.031186718,0.104638904,-0.028617565,-0.06939115,0.03777844,-0.002405009,-0.02930683,0.06908864,0.026073903,0.06021646,0.06627379,0.026217677,0.0071098143,0.01927344,-0.05006984,-0.05482002,0.027948173,0.03722883,-0.009534973,-0.010895923,-0.07740439,0.056737646,0.0024033783,0.07242576,0.0154458415,-0.0027909172,0.023404181,-0.023876539,-0.054389592,-0.014664146,-0.049327005,-0.09761889,-0.07563431,-0.062907934,0.019382218,-0.043173578,0.07363933,-0.043567672,0.012354714,-0.038892798,0.031419847,0.114922635,-0.037796456,-0.00028223151,-0.017626835,-0.02258811,-0.12631123,0.068736665,0.027443046,-4.5457156e-08,0.023274297,-0.07480325,0.02089058,-0.028121278,-0.015925614,0.08267759,-0.017074887,0.05642629,0.06256822,-0.0023080297,-0.011354741,-0.007057563,-0.043336328,-0.06976903,-0.046765316,-0.020030586,0.01564399,0.07858079,-0.016908541,-0.08230351,-0.029920172,0.04613384,-0.0013362595,-0.04139266,-0.006880165,0.011480005,-0.019766657,0.06290056,0.05216306,-0.10956288,0.03522139,0.009595933,0.040119138,-0.013360054,-0.058903202,-0.03029633,0.06786894,-0.058747243,0.03682706,0.017905887,0.022645222,0.0195466,-0.089914866,0.027860679,0.024225371,-0.033925377,-0.039535187,0.044278678,-0.047874395,-0.022173349,-0.0052410113,-0.06097119,0.0067382394,-0.07317995,-0.045630865,0.009409949,-0.09015293,-0.022172356,0.018572114,-0.05707175,0.00049237325,0.010023886,0.09519942,-0.023720363 +2.1.1.371,"This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. The human NSD3 protein also catalyses the activity of EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase. cf. EC 2.1.1.369, [histone H3]-lysine27 N-methyltransferase, and EC 2.1.1.356, [histone H3]-lysine27 N-trimethyltransferase.",384,0.99999994,-0.0020670518,-0.01015333,-0.08590787,-0.045743573,0.017512916,0.08094267,-0.054087646,-0.022068895,-0.0041328077,-0.017675418,0.008172346,-0.030401722,-0.03847661,0.0026056257,0.05783451,0.042293694,-0.15524863,0.029506626,-0.05651149,-0.10295413,0.029341916,0.12249619,0.024700126,-0.027895454,0.012450181,-0.02149931,0.03472195,-0.011743023,0.09753909,-0.035110626,0.0619492,-0.06478327,0.057314552,-0.035521597,0.12155807,0.018360972,-0.0074310782,-0.023783972,0.009647577,0.0012440042,0.060525585,-0.0020627645,-0.03522901,0.019597664,-0.052276656,0.013915983,-0.018612504,-0.03277617,-0.020973358,0.01763338,0.03967549,-0.05379085,0.018807288,-0.014325809,-0.019215327,0.007770733,-0.06825492,-0.021166276,0.05176777,0.02429514,0.025304351,-0.013726546,0.045687217,-0.031969484,0.10347083,-0.10688264,0.06617157,-0.055159904,0.04710784,-0.030746223,-0.0499335,-0.07656854,0.01399394,0.05253822,0.029314991,-0.039228022,0.0028392293,0.018463876,-0.03395315,-0.080814615,-0.019126587,0.014899293,0.07241304,0.05477506,0.030055711,-0.043053098,-0.06180918,0.058754917,0.031652294,0.061786562,-0.046984635,-0.072290756,-0.017274685,0.03171423,-0.047207903,0.07176556,0.053889323,0.07463322,-0.012136633,0.021131212,0.04893963,0.08038195,-0.12972102,0.026988523,0.05048549,0.07319073,-0.016716015,0.07965656,-0.056474354,0.0137691805,0.049752716,0.023094004,0.016467055,0.023000492,0.0022729104,0.071645774,-0.02673073,-0.041261148,0.018254858,-0.0131229125,0.02098998,0.038179692,0.04000347,0.04885128,-0.06835901,-0.005020986,-0.10838253,3.3171304e-33,0.00877908,0.079801574,-0.02525397,0.010268935,-0.0622175,-0.027229413,-0.07038486,0.039309654,0.021169059,-0.07131008,0.030768022,-0.022238353,0.098638296,0.01617403,-0.08683019,0.00027872168,0.0029610465,-0.011331916,0.00998402,-0.040991846,-0.029549241,-0.032394342,-0.021144742,0.028598413,-0.0030479287,-0.044827707,0.00085465505,0.0381494,0.10734958,0.004230942,-0.060478237,-0.08817313,0.04792292,0.03402292,0.009408006,0.03628417,0.024620295,-0.023328368,-0.005134782,0.09763988,0.04112012,0.01585658,-0.028972788,-0.0927372,-0.03337392,0.00065819855,0.015183826,0.06164164,-0.055789985,0.009046226,0.0351908,-0.03763622,0.08843125,-0.06328432,-0.032881677,-0.00594987,-0.026375078,-0.0662997,0.013025611,0.03517216,-0.056840256,-0.032644227,0.034588773,0.081064135,0.05428518,-0.037746895,-0.034463905,-0.016278928,-0.07094857,0.0017830253,-0.086566,0.04105789,0.13687633,-0.004276701,0.02453463,-0.08102582,-0.14589077,-0.020567777,-0.02959533,0.06603131,0.051114686,0.033303697,-0.047212273,-0.090644255,-0.0131678255,-0.06767545,-0.016165543,-0.11772656,0.008550753,0.012757232,-0.016431034,-0.11846266,0.013622639,0.046950184,-0.013066519,-4.353421e-33,0.00046900686,0.02941972,0.016534379,-0.050692216,0.011740945,-0.0015812834,0.076753885,0.067155,-0.03055627,-0.04319903,0.070249714,-0.035514623,0.040543854,-0.11271917,0.023171948,0.0152567355,-0.002563596,0.041042943,0.0014948873,-0.0065195165,0.02173325,0.0002336285,-0.09078261,0.12472275,-0.043946385,0.06635047,-0.05874937,0.024997704,0.08725618,0.082207106,-0.041276664,-0.008837395,-0.03222225,-0.025605744,0.016831087,0.04072046,-0.037854105,-0.013768481,-0.01929236,-0.032422766,-0.02852326,0.027880425,0.01804736,0.048774302,0.021976145,0.15101951,-0.0024288592,0.082946375,-0.016949555,-0.0781726,0.022680655,-0.017013662,-0.029719913,0.083099216,0.018389016,0.044099502,0.0612116,0.0066181384,0.03316599,0.021716455,-0.016937086,-0.021478605,0.013052023,0.0311997,-0.02855555,-0.015693747,-0.09130501,0.059842672,0.02351582,0.09706583,0.009039113,-0.004008614,-0.0056281085,-0.026893811,-0.0516004,-0.034472413,-0.028167283,-0.07901099,-0.08015683,-0.07715805,0.036650747,-0.050355345,0.05457734,-0.033748712,0.03459109,-0.03437677,0.01560635,0.084558345,-0.04147395,0.022351205,-0.028675273,-0.010129661,-0.12808427,0.08075967,0.029873673,-4.4411316e-08,0.016717657,-0.096256554,-0.0018201818,-0.0102046365,-0.0032333569,0.08763289,-0.01881269,0.073871836,0.050814524,0.01340805,-0.01698559,-0.020421714,-0.01881727,-0.060266633,-0.059459195,-0.017248709,0.029349584,0.086448036,-0.018793836,-0.08968444,-0.013037278,0.03272476,0.039734196,-0.028974066,-0.0005245365,0.013148297,-0.033173114,0.09387883,0.04595934,-0.09967133,0.021874411,0.00054200744,0.036437478,-0.00573212,-0.033455618,0.0016547607,0.07616491,-0.07163718,0.026158018,-0.003383775,0.037288114,0.0344368,-0.110280715,0.034522638,0.03626217,-0.03836156,-0.047249045,0.049659073,-0.031690475,-0.017291095,-0.008683219,-0.052660916,0.0099148955,-0.06578555,-0.04619106,0.010548406,-0.10713493,-0.012533887,0.014230159,-0.042821463,0.020823674,-0.008222512,0.093508705,-0.03286035 +2.1.1.372,"The enzyme, characterized from the fission yeast Schizosaccharomyces pombe, catalyses three successive methylations of the L-lysine-20 residue of histone H4 (H4K20), forming the trimethylated form. The methylation of this site is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response. cf. EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase, and EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase.",384,0.99999994,0.04462987,0.053759176,-0.0538341,-0.074389204,0.039808612,0.08155285,-0.050339736,0.03635642,-0.050479606,-0.0010525499,0.031187132,0.023681557,-0.066744246,-0.01333527,-0.02200675,0.08414301,-0.12406015,-0.012944181,-0.05492029,-0.07432461,0.05152985,0.08035439,-0.009332659,-0.039729737,0.02194763,-0.049519718,0.017541517,0.0035622625,0.035941396,-0.071615525,0.051831957,-0.036592655,0.06301091,-0.042917,0.06608962,0.026125096,0.04266319,-0.03318131,0.060927734,-0.008694404,0.013350093,0.003604812,-0.0665186,0.06341738,-0.06073592,0.052725777,0.05923738,-0.0369782,-0.012501593,0.003961912,0.0028501712,-0.012339942,0.06322287,-0.03731346,-0.018565929,0.0023237963,-0.037881985,-0.048310794,0.057208944,-0.001403151,0.006987779,-0.04376056,0.0065908367,-0.028613819,0.063124485,-0.0464479,0.12634893,-0.049888268,0.006398698,0.019691681,0.00032446085,-0.06366048,-0.046428952,0.025133528,-0.025790801,-0.025135024,0.015632665,-0.055626247,0.03710471,-0.0055931048,-0.052790888,-0.026061073,0.10127109,-0.025652193,-0.017246002,-0.039287042,-0.0592253,0.06703905,0.117560394,0.075539574,-0.021322567,0.004344692,0.030905914,0.021926058,-0.052274853,0.09159521,0.005572432,0.05528921,0.003279704,-0.020176034,0.05261992,0.031407584,-0.09738641,0.014976765,0.037225626,0.09312675,0.04325992,0.07780559,-0.0054729404,0.012425157,0.0057720025,0.043917127,0.022048684,0.016614033,-0.042701688,0.0037144267,0.0055221897,-0.003023675,0.0082758665,-0.03161335,0.0116105415,0.03195083,0.009987696,0.03793829,-0.080127366,-0.015664786,-0.101887904,2.7132656e-33,0.0013583718,0.09301189,-0.047068793,-0.0056560873,0.00951484,-0.03951457,-0.062197097,-0.0070365076,-0.033082195,-0.089724235,0.007975851,-0.07768811,0.01476915,0.037374765,-0.10304589,0.006996064,0.025925422,0.009580584,-0.003919445,-0.028033683,-0.08263425,0.0032351976,-0.046722397,0.013539511,0.041532107,0.014217414,0.044487186,0.018169517,0.03589965,0.009993651,-0.074003175,-0.074892834,0.019248378,0.03805449,0.05886333,0.03368974,-0.025420805,0.041515555,-0.008070198,0.05069616,-0.0104563935,0.023216195,-0.049733076,-0.020498604,0.010566752,-0.021369634,-0.024915725,0.043738678,-0.05803781,0.057508826,-0.027038269,-0.047858834,0.077055305,-0.012641546,-0.03172549,0.019160835,-0.022131832,-0.059197858,0.017388338,0.031745072,-0.05267443,0.029859845,0.038941637,0.06071145,0.07355096,-0.08181054,-0.02460124,-0.05355176,0.0015910077,-0.018026182,-0.030395804,0.018807473,0.11102856,-0.023565069,0.017255247,-0.09742839,-0.120747805,-0.03755428,-0.051392574,0.10348021,0.034625974,0.0044279066,-0.067777425,-0.09505553,-0.027947789,-0.0059050797,0.04020079,-0.09075847,-0.007773594,-0.013922694,0.01893575,-0.13900615,0.04870393,-0.009054417,0.044062085,-5.2559254e-33,0.025663732,0.002806619,0.075894184,-0.03308632,-0.055588014,0.03076298,0.091210276,0.049846184,-0.07819112,-0.030777322,0.082169436,-0.024122076,-0.05970403,-0.053632066,0.007937927,0.02069498,0.031507876,0.08698494,-0.01930211,-0.008158878,-0.030015493,0.09120696,-0.07414153,0.1599871,0.052698635,-0.019876007,-0.027832765,0.053680215,0.09134376,0.04103753,-0.040600378,0.0072587514,0.024145402,0.0019292714,0.07029463,0.040057175,-0.061087262,0.0303036,-0.025811866,-0.038954444,0.00624898,0.019275852,-0.030839102,0.062459677,-0.042084284,0.12949932,-0.070982106,0.10577968,-0.010754207,-0.07775346,0.00859067,0.012934156,-0.030858243,0.059672955,0.08316288,-0.006499235,0.03508158,0.03807898,-0.09385281,0.016350608,-0.08651385,-0.032801263,0.026083121,0.068464786,0.037526283,0.022806903,-0.09633525,0.023367716,0.022085538,0.044294,0.004195901,0.036203634,0.049683783,0.008530498,-0.052530058,-0.00042275264,-0.09216316,-0.09085652,-0.11441332,-0.03472703,0.025844593,-0.08873385,0.04504657,-0.030451164,-0.0096491035,-0.13598321,-0.0048639383,0.09011588,-0.034242984,-0.0007692946,0.021843666,-0.022161338,-0.12082012,0.0687822,0.013506874,-4.4881435e-08,0.025651708,-0.068022445,0.018304612,-0.08490425,-0.020332832,0.07138103,0.0051538376,0.0036301806,0.08051403,0.046616837,-0.049176883,0.014861214,-0.0150662055,0.01479956,-0.07192612,-0.038415886,-0.024464633,0.072649226,0.0013528357,-0.0272084,-0.084456734,0.021184482,-0.02284741,0.016146252,-0.0010953867,0.023045115,0.036658283,0.07792134,0.06896758,-0.11576207,0.058221795,0.015268441,-0.008589721,0.02529654,-0.05619531,0.05010703,0.024822181,-0.051126283,0.05788372,0.039000873,-0.00016089581,0.0024929936,-0.05634903,0.03124344,-0.01470762,-0.04038594,0.011353021,0.032113962,-0.042381488,-0.047874205,0.01602392,0.044904802,-0.055563964,-0.05430959,-0.05985041,0.044729237,-0.04900488,0.012133141,-0.0017305533,-0.015662452,0.038313728,-0.0260394,0.0656263,-0.0992353 +2.7.7.105,"This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor, in mycobacteria. cf. EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase and EC 2.7.7.106, 3-phospho-(R)-glycerate guanylyltransferase.",384,1.0,-0.009887335,-0.017016819,-0.12279053,-0.001826268,0.009508782,0.005011177,-0.04197898,0.07070355,-0.0716925,0.008473732,0.017197015,-0.07593022,0.01810529,0.010706155,-0.041021645,0.012429767,-0.005539152,0.001928777,-0.043133605,-0.06413656,0.0793267,0.06257087,-0.03247601,-0.05508716,0.0077296463,0.0018660269,0.012498668,-0.0014922606,-0.011362815,-0.09362333,-0.04079565,-0.06749906,0.09832129,-0.026485305,0.081869334,0.09213974,-0.028356131,-0.10907218,0.10415657,0.048316803,0.017820472,0.04909421,0.05542936,0.003897898,0.004244375,0.056806277,0.0057670325,-0.006768998,0.0020730055,-0.012218853,-0.07188831,0.031086143,-0.059190962,0.055279996,0.053373396,0.051826186,0.019793432,-0.104143776,-0.02680135,0.026634863,0.07261142,-0.044981144,0.041166384,0.036172275,-0.02206688,-0.0019201281,0.04001866,-0.032883473,0.0065523325,-0.05239753,-0.085279286,-0.021555886,-0.058339976,0.022078978,-0.015046419,-0.016840518,-0.009059586,-0.015600353,0.045353994,0.0654558,0.023970446,-0.05572952,0.025306044,-0.04421495,0.04951115,-0.071450375,0.05466566,-0.046507668,0.015711483,0.07073239,0.008016263,-0.062972255,0.033251397,-0.0035794443,-0.12139908,0.006855289,0.063577466,-0.0063267727,0.0016068182,-0.050017472,-0.014810592,-0.0023535187,0.033575166,-0.025778348,-0.060869798,0.020548739,-0.0061384644,0.092774734,0.07303014,0.053528804,-0.06595616,0.043360364,0.042519722,-0.019813042,0.006753835,0.11281717,0.073400006,-0.037608027,-0.04043178,0.07338705,0.06617436,-0.032886554,0.010225489,0.00010375107,-0.09013246,0.021650221,-0.10701626,2.5194124e-33,0.061069265,0.059857596,0.00881189,0.018094558,0.054495037,-0.03307587,-0.12232998,0.004936341,-0.07529831,-0.0561973,-0.049379203,-0.051649097,0.03370839,0.048527025,-0.0954905,0.041450128,-0.034822866,-0.05864752,0.04893456,0.03313838,0.00034675386,0.01665286,-0.005542131,0.0072312877,0.040713616,0.0549208,-0.008735049,0.028871208,0.018728828,0.007624295,0.01310226,-0.104686104,-0.08610466,-0.035954468,0.036099244,-0.063639425,-0.034843944,-0.08243878,-0.0069871065,0.015190995,0.0035050327,0.018558305,-0.035913974,-0.01647053,0.08449272,-0.053939253,-0.023518428,0.07201812,0.061319537,0.12496947,0.004920843,-0.05186051,0.035473812,-0.0013108404,-0.05555133,-0.061759062,-0.056761872,0.022685666,0.028562136,0.042886794,0.03858816,0.0536048,-0.012190136,0.09226989,-0.00022156056,0.016433196,-0.043819506,0.0060580354,0.021400167,0.0724213,-0.042739566,-0.039252874,0.020518627,-0.0137475245,0.0654779,-0.071696565,-0.005759869,-0.098058544,0.03339147,-0.03184645,0.029894039,0.051217407,-0.044765353,0.010457953,-0.031516474,-0.05480074,-0.06587905,-0.019036245,0.028070645,-4.3358337e-05,0.057933718,-0.032620765,0.013719619,0.030166158,-0.0053066737,-3.7587218e-33,0.122582845,-0.12726685,0.061698627,-0.090344526,-0.0030518905,-0.013404503,0.053040966,0.0099077895,0.040927645,0.004669209,0.10741512,-0.019422982,0.047657557,-0.026580967,0.009919423,0.017212952,0.041617587,0.039157886,-0.015459116,-0.04779103,0.032805845,0.07128818,0.028279485,-0.061156996,-0.00035023337,0.028581759,-0.06849016,0.0412638,0.017421314,0.07931945,-0.055460043,-0.037124235,-0.044386327,-0.041714214,-0.108939454,-0.00020592049,-0.08582201,0.02719355,0.025312945,-0.053005464,0.018891793,0.08244816,0.0008501211,0.0027560277,0.0074909874,0.02575286,-0.07468649,-0.034490056,0.05004218,-0.025656004,-0.050922353,0.018070102,-0.078312255,-0.008485485,-0.038275044,0.042342,0.04656447,-0.017221387,0.0044250255,0.00073683227,-0.063041486,-0.03641357,0.028114721,-0.0036639178,0.1214984,0.0905818,0.007152634,0.06842511,0.08469981,-0.014784308,0.079199195,0.039447866,0.0070307567,0.04844143,0.020643687,-0.029408237,-0.102594875,0.016606683,-0.06239445,0.02970921,0.017213194,-0.035231493,0.021917403,-0.05055716,-0.06919041,-0.15428433,-0.019926729,0.08485416,0.037757285,0.01601653,-0.042464726,0.030155536,-0.047806352,0.012912994,0.05365637,-3.976998e-08,0.0041513587,-0.02175791,0.029757662,-0.04179901,0.06698679,0.1096464,-0.036223285,-0.03711794,0.059059475,-0.0067601455,0.04573894,0.09407588,0.04961373,-0.023852853,0.038101997,0.04168693,-0.05346403,-0.031589158,0.032624424,0.029514624,-0.048204575,-0.02902187,-0.053095907,0.08179808,-0.01450981,-0.051472455,0.033738922,0.07913253,-0.019848691,-0.0693225,-0.023940789,0.052284777,0.030823765,-0.025599651,-0.15974687,-0.030425468,-0.018739957,-0.037838828,-0.07186541,0.025633369,0.025707003,-0.012775576,-0.0627887,0.02417781,0.033003487,0.048263267,0.031456202,-0.0475544,0.0065707853,-0.007935053,0.037855264,-0.021656776,-0.024357213,0.030249529,-0.06113927,0.012105405,-0.024450254,0.019407753,-0.031124549,-0.036746964,0.03495244,0.016994176,0.14149196,-0.08035595 +2.7.7.106,"The enzyme, characterized from the Gram-negative bacterium Paraburkholderia rhizoxinica, participates in the biosynthesis of 3PG-factor 420. The enzyme can also accept 2-phospho-L-lactate and phosphoenolpyruvate, but activity is much higher with 3-phospho-D-glycerate. cf. EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase and EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase.",384,0.99999994,0.0043600807,-0.096554205,-0.10671597,-0.031567086,0.018016806,0.055956397,-0.06740269,0.043224365,-0.011771679,-0.027172402,0.065182276,-0.025978662,-0.03508143,0.05680222,-0.035980873,0.035686687,-0.0062424177,0.06676118,-0.055895276,-0.07263682,0.11986332,0.039128557,-0.02157862,-0.017740374,0.06039278,-0.002635822,0.038122356,-0.054956358,0.030662017,-0.045291495,-0.082754046,-0.04744697,0.0063430453,-0.06936247,0.09655696,0.17057681,-0.08578454,-0.040853404,0.07407489,0.01664785,0.06923004,0.0018476775,0.021845877,0.025685294,0.0141449915,0.046898227,-0.023672523,0.07121453,0.042268835,-0.055809177,-0.07656485,-0.018884284,0.019027038,0.06663044,-0.0060929838,-0.0122932745,9.363032e-05,-0.0129648,-0.03450901,-0.018268349,-0.059665836,-0.0055240723,0.06674188,-0.022716027,-0.009946225,-0.020331547,0.05363934,-0.061902016,-0.059426486,-0.01436329,-0.12092625,-0.04159745,0.04165388,-0.028691193,-0.026215363,0.051447913,0.0075217504,0.020647328,0.014628311,-0.016494934,0.11823003,-0.059644114,0.051007587,0.08196923,-0.012486426,-0.05917465,0.019032802,-0.015811866,0.0072136833,0.066293515,0.023764653,-0.0077356864,0.04325416,-0.06411533,-0.08185415,0.05570427,-0.058192804,-0.046839997,0.0048790285,-0.058175374,0.0077486266,0.05584553,0.013173148,-0.0428871,-0.06457801,-0.0032288558,-0.028153319,0.08337425,0.053457085,0.016944166,0.0065853763,0.02039017,0.012740407,0.0063547683,-0.020425674,0.05572154,0.045610067,-0.05591618,-0.045388803,-0.03242325,0.0010904482,-0.000630881,0.07753615,-0.040418506,-0.058144346,0.058163624,-0.10577499,5.528726e-33,0.087602794,0.01606614,-0.023562156,-0.027389755,0.012456161,0.031719036,-0.09273978,0.011029079,-0.06575402,-0.025025776,-0.07245788,-0.13054074,0.013136686,-0.017487107,-0.019233681,0.08550133,-0.073349655,-0.04006128,0.026913662,0.021923907,0.013655811,0.04636341,-0.045857586,-0.022050519,0.07563605,0.081853464,-0.00039531552,0.0016002301,-0.015398629,-0.016758699,-0.013940022,-0.04754448,-0.14887688,0.012387943,0.040675595,-0.048423517,0.008883677,-0.11278754,0.026719294,-0.0035902609,-0.02093724,0.048983816,-0.0023488768,-0.041307613,0.058921263,0.005153352,0.04819573,0.047961343,0.03194066,0.09316014,0.01642943,-0.0019407404,0.11805929,-0.02448266,-0.046197403,-0.09810554,-0.030897079,0.037536893,0.07704043,0.02521651,-0.02229187,0.05512774,0.01578432,0.005692434,-0.0032589221,0.034296673,-0.066474706,-0.056947216,-0.008560953,0.0851923,-0.029316207,-0.05973566,-0.0054151765,-0.0007692656,-0.005919644,-0.11191865,-0.0018300114,-0.009212399,-0.016666247,-0.029637171,-0.0036836416,-0.020652864,0.025087614,-0.0010623507,-0.02539819,-0.006602366,-0.06384616,-0.020639354,0.030711971,-0.021813015,0.0750881,-0.015816232,0.026447736,0.0607733,-0.027481347,-4.7455096e-33,0.11960314,-0.085407175,0.030928105,-0.017030794,-0.020916311,-0.010130237,-0.02423107,0.052598763,0.04691686,-0.03286494,0.07837535,0.026495663,0.034811076,0.013617973,0.058894485,0.0060401703,0.021562776,0.059429225,-0.021599608,-0.07775,0.031173019,0.08057768,-0.002857448,0.046820704,0.05478217,0.080284305,-0.01675214,0.07480127,-0.029941062,0.04151739,-0.012678815,0.04924439,-0.055885617,-0.0485434,-0.087922364,-0.0040717013,-0.058473703,0.019428,-0.024828903,0.052312125,0.04397035,0.09117639,0.06483838,0.066900335,-0.026773352,0.07924282,0.011978524,-0.02905598,0.048823565,-0.06692746,0.00990959,-0.027462326,-0.010655506,0.04846383,0.031098172,0.039196614,-0.0013701934,0.021661216,-0.03609797,-0.030434832,-0.03499463,-0.06353174,0.026971431,-0.05326648,0.08523432,0.07759144,0.02264982,-0.011174528,0.066996105,0.002721247,0.031243293,0.033618186,0.007397531,0.09255138,-0.049094737,0.016201971,-0.06362564,-0.024890566,0.067836344,-0.03046195,0.077826954,0.03597499,-0.012943711,-0.041517634,-0.020333566,-0.11007096,-0.025924027,0.1434502,-0.003359104,-0.006128706,-0.039209507,0.010027082,-0.029893594,0.08975522,0.055710126,-4.6707132e-08,0.08240091,-0.01892885,-0.0075228345,-0.04572576,-0.002338178,0.045011915,0.0010447579,0.024359649,0.053598825,-0.0021353178,0.007965194,0.038968578,-0.0074131642,-0.0015123315,0.057488833,-0.016129963,-0.06169082,0.0562729,-0.038234193,0.021508245,-0.026773017,-0.05494363,-0.12783945,0.06704123,0.06365978,-0.07691008,0.054284755,0.029517226,0.007256989,-0.05105682,-0.029480923,0.0056825853,0.016283844,0.008116753,-0.10395229,-0.015444759,-0.11150059,-0.021039682,0.004033684,-0.015441791,-0.0015747267,-0.046819266,-0.04884322,0.009732652,-0.08614445,-0.020022798,0.022214144,-0.08582973,-0.009156727,0.00050208793,0.019087834,-0.020571843,0.03395802,0.036032032,-0.06728096,-0.021226376,-0.0046431534,-0.03921401,-0.02892535,-0.07932297,0.060423132,-0.022873748,0.16098082,-0.025648635 +6.2.1.65,"The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A.",384,0.99999994,-0.043468427,-0.030582722,-0.07151963,0.02567697,0.051433947,0.06927912,-0.020215474,0.0024258227,0.080054484,0.0059031365,0.00507495,-0.0038365722,0.007439214,0.049051158,-0.04415484,0.09713932,-0.10180092,0.040412854,-0.03037248,-0.048729703,0.09738014,0.050438046,-0.000120338744,-0.012089714,0.018795116,-0.016608695,0.048460234,0.0004671676,-0.03592935,-0.056804623,0.024974583,0.022112098,0.095013455,-0.027236963,0.10322361,0.1379423,0.016987719,-0.11061517,0.03203525,0.06198299,0.0061864145,-0.009564916,-0.024778692,0.012076385,-0.055858754,-0.016598227,0.019608198,0.062259257,0.017071005,-0.042884734,-0.08536838,-0.06560431,-0.060336854,0.0034610485,-0.0075789797,0.087199084,-0.040993128,-0.029860614,-0.047551833,-0.04661761,0.02155693,-0.008862021,0.033469226,-0.0130042415,-0.0027691217,-0.05399448,0.043288495,-0.07487491,0.06043345,-0.06059581,-0.15120605,-0.07903807,-0.018361002,-0.00084060995,0.05515008,-0.06167071,-0.034178417,-0.04570836,0.015273931,-0.02404312,0.036476906,-0.013427293,0.027197253,0.05642925,0.11513915,-0.026140297,0.03176264,-0.062724866,0.099239625,-0.006240711,-0.0019108125,-0.0326458,-0.0041100704,-0.030214425,-0.10524849,0.0020532403,-0.0045271767,-0.018526712,0.029159293,0.039717484,0.01648856,0.010647346,-0.023908844,-0.061946932,-0.012252303,0.010376544,-0.03913623,0.10983574,0.013340271,-0.029545676,-0.01361785,0.041628473,0.038419012,-0.014836552,0.03792688,0.07588548,0.019687183,-0.04773238,-0.046708368,0.008584882,-0.041148774,-0.035168305,0.02812992,0.009442685,-0.026551524,0.068420745,-0.12452503,2.9418114e-33,0.06454899,0.009895897,-0.001484553,0.00026422399,-0.041481033,-0.043851398,-0.034206357,0.04171203,-0.026312571,-0.08055872,-0.02551777,-0.05573048,0.05017912,-0.0005101659,0.03328832,-0.036020182,-0.037670538,0.02809541,0.06863545,0.027489334,-0.027221104,0.04856296,-0.0029866837,-0.015342802,0.01657679,0.029973483,0.0058381627,0.02375047,0.043760166,-0.0082882065,0.026361682,-0.06888731,-0.13385387,-0.0361463,0.04487704,0.0018510305,-0.075856104,-0.021441227,0.011444569,0.072709054,-0.04061285,0.04515798,0.012076684,-0.012508312,0.025346778,-0.063322306,0.00950068,0.13995026,0.08429176,0.047916584,0.055193424,-0.05229911,0.09430202,-0.000108663255,-0.07882826,0.018450217,0.010895516,-0.05343089,-0.02864819,-0.009084412,0.016931843,-0.05063421,-0.04141268,0.034046426,0.0265786,0.031104254,-0.0627585,-0.0198735,0.038512055,0.123381756,-0.045507785,0.0060355766,-0.00216454,0.0502673,-0.022255754,-0.07444671,-0.08715953,0.040903687,0.100211315,0.038289256,0.011670499,-0.017305885,-0.008853965,-0.0007366082,-0.08014024,-0.020352429,0.007932778,-0.08277876,-0.016351469,0.0346284,0.04867419,-0.09104648,-0.034467254,0.015845176,0.078431524,-3.4557054e-33,0.11184094,-0.061747286,-0.013051842,-0.029673146,-0.06567387,0.009771409,-0.005389005,0.023308685,-0.08568728,-0.050444625,0.102634765,-0.025031365,0.03878439,-0.0023060623,0.0058274018,-0.053154025,0.04630759,0.03724198,-0.039248083,0.003968721,0.0032164764,0.047280464,0.03291759,-0.040565483,-0.003585594,-0.0066577164,-0.04005768,0.051013187,0.06636607,0.0435341,-0.022173544,0.016391864,-0.06299636,0.003587287,-0.038894035,0.051522814,-0.08111892,0.018523008,-0.007659711,-0.029284133,0.09712024,0.0013693897,0.005632837,0.11457817,0.03225281,0.105212554,-0.042852,0.0010994505,-0.002788067,-0.08853717,-0.008500932,-0.021335186,-0.0011788666,-0.009385337,-0.034827624,0.08283603,0.011462478,-0.09843435,-0.0335231,-0.041624933,-0.04936452,0.0134871965,0.014085155,0.034619782,0.04629407,0.020440947,0.009298548,0.039500374,0.0690243,-0.06845434,0.09444263,0.07591568,0.05506587,0.024136856,-0.060980964,-0.053021368,-0.13281053,0.018642653,-0.036247067,-0.029919578,-0.008748764,-0.069090754,-0.019662138,-0.071735926,-0.030984916,-0.036167398,0.028258674,0.027521472,0.0044026934,0.04422239,0.0025332738,0.006056622,-0.032615267,0.035506766,0.02817917,-3.597304e-08,-0.03986374,-0.04876886,0.015778707,-0.08502553,-0.0064834836,0.060260322,0.027553106,0.024502128,0.037927218,-0.0040222956,-0.053151686,0.0679429,0.04779787,0.03463978,0.007366302,0.061980665,-0.022420252,-0.007977156,-0.015000083,-0.067704186,-0.111698456,-0.038945887,-0.03070871,0.1233251,0.02320804,-0.023782384,0.06917344,0.121191666,0.018867359,-0.04884937,0.01365176,0.006261539,0.038987327,0.020327108,-0.061852742,0.0318329,0.0155734485,-0.039492246,-0.02258741,0.067211874,0.032816667,0.024006946,-0.15544315,0.010403853,0.08909843,0.030253608,0.011392937,-0.006770147,-0.030737478,-0.032394107,0.068556294,-0.03405346,-0.039721876,0.019211896,-0.10483815,-0.01857049,0.019195853,-0.05057804,0.0050346656,-0.014087484,0.030087024,0.006693764,0.13168298,-0.08486684 +6.2.2.2,"Requires Mg2+. The enzyme, which participates in the biosynthesis of ribosomal peptide natural products (RiPPs), converts L-cysteine, L-serine and L-threonine residues to thiazoline, oxazoline, and methyloxazoline rings, respectively. The enzyme requires two domains - a cyclodehydratase domain, known as a YcaO domain, and a substrate recognition domain (RRE domain) that controls the regiospecificity of the enzyme. The RRE domain can either be fused to the YcaO domain or occur as a separate protein; however both domains are required for activity. The enzyme can process multiple residues within the same substrate peptide, and all enzymes characterized so far follow a defined order, starting with the L-cysteine closest to the C-terminus. The reaction involves phosphorylation of the preceding ribosomal peptide backbone amide bond, forming ADP and a phosphorylated intermediate, followed by release of the phosphate group. In some cases the enzyme catalyses a side reaction in which the phosphorylated intermediate reacts with ADP to form AMP and diphosphate.",384,1.0,-0.06948962,-0.12216742,-0.0798108,-0.06871297,0.06314241,-0.0403386,-0.074580036,0.058727477,0.003641575,-0.0015036905,-0.027500441,0.007863609,0.03425571,0.06558731,0.057838164,0.04474899,-0.046437286,0.08137528,0.0022042098,-0.021133546,0.15906128,0.030281924,-0.039306454,0.02047802,-0.030728685,-0.013826382,0.07164761,0.022864476,-0.035328414,-0.017537924,-0.035282776,-0.03869753,0.017944543,-0.05239714,0.028434943,0.1067085,-0.037370637,-0.05219418,-0.018957477,-0.078819774,0.024864243,0.020988313,0.043305263,-0.048972875,0.037471794,-0.038328446,0.05399352,0.08004458,0.012070283,0.021750437,-0.0455675,-0.034343585,-0.059199195,0.058060892,-0.06350042,0.05640463,-0.057843875,-0.01053857,-0.025279524,-0.0069884383,-0.081155695,-0.01473865,-0.039919037,-0.010787261,0.08446526,-0.10616071,-0.052802637,-0.02857718,0.0029635332,-0.0011437702,-0.04622732,-0.09314545,-0.030701898,0.054404054,-0.037533253,0.061808664,0.019253297,0.002466901,-0.04610303,-0.021197082,0.057112627,-0.0035022453,0.069174655,0.085567996,0.024546284,0.030962422,0.01107896,0.04312509,0.060858175,0.04725183,0.095778905,0.028768543,0.029315006,0.035263825,-0.016255789,-0.017742414,0.036424197,0.033999454,-0.02039187,-0.03018719,0.0025952598,0.054980054,0.025519725,-0.026153477,0.023991428,0.064278096,-0.038033843,0.08905799,0.02355049,-0.0024501008,0.028829174,0.049818575,0.07226364,0.021085097,0.039850842,0.05573302,-0.036823805,-0.0828911,-0.016329905,-0.05379698,-0.012238209,0.021433832,0.023408119,0.028270176,0.017275522,0.062452737,-0.09193779,3.5229577e-33,0.008659851,0.046133593,0.043471627,-0.03205652,-0.059632026,0.023026075,-0.06397996,-0.005230296,0.035662625,0.034555063,-0.057865012,-0.047652364,0.06037388,-0.0013204743,-0.05199511,-0.07256714,-0.0042556045,0.057233177,0.0768488,0.083113246,-0.06314264,0.06654625,-0.03019142,0.05383274,0.017260233,0.089739256,0.008547197,-0.07958716,0.0007374359,-0.0013466201,0.010309141,-0.069891654,-0.117665306,0.044417616,0.048142474,-0.012071424,0.020521915,-0.022647433,-0.011809891,0.039010517,-0.021516224,-0.03976919,-0.05066142,0.031914648,0.049897116,-0.094228044,-0.028886113,0.088357165,-0.03308419,0.08652675,0.10720724,-0.03852213,0.07680047,-0.022762693,-0.08307467,0.015832538,-0.082986206,-0.027017608,0.077922344,0.0025913108,0.006571309,0.0020845048,-0.041768152,0.07159957,-0.00083016406,0.026984839,-0.036059063,-0.19114764,0.026545387,0.12054936,-0.03980655,0.006655949,0.078691766,0.02949639,0.010993103,-0.051590182,-0.051590476,0.024120225,0.056365404,0.05464411,-0.023843396,0.03227633,-0.043023042,-0.021313105,0.0019010154,-0.006304147,0.053221483,-0.092561215,-0.04988031,-0.028927777,0.044774473,-0.042088207,-0.014694724,0.07752641,0.026063126,-3.7802965e-33,0.11398721,-0.11934145,0.061808906,-0.015168162,-0.063935764,-0.034066863,-0.016154807,-0.09373919,0.041332692,-0.13393825,0.028506512,-0.038158055,-0.044749927,-0.020087622,0.024470352,-0.074209586,-0.0011706117,0.075180806,-0.022812363,-0.027139504,0.004494145,0.06371949,-0.0011072877,0.0738331,0.066627264,0.016042786,-0.026719114,0.044035677,0.09615387,0.024249768,0.008648294,0.052034646,-0.035577755,-0.028045138,-0.02403131,0.124336325,-0.06908058,0.015827186,0.06388988,0.08679021,-0.020053837,0.039807495,-0.038977213,0.06488777,0.001008021,0.0518298,-0.03302856,0.06500981,0.02614891,-0.07300882,0.049049594,-0.035407305,-0.035598345,-0.0024678614,0.06556712,0.027702259,-0.0067020953,0.012531608,0.0033548728,-0.029012429,0.001801636,-0.024877757,0.016338551,-0.011421764,0.012413631,0.0823762,0.048999675,0.0053986213,0.03550802,0.06680624,0.055705115,0.055270497,0.045215003,0.017253635,0.044929657,-0.019645149,-0.07351783,-0.051645502,-0.039366968,-0.09044584,-0.013248437,0.034623045,0.029042501,-0.029032143,-0.021916725,-0.057297174,-0.0062558204,0.06858435,0.029968746,-0.039469905,-0.012929608,-0.075078346,-0.015823737,0.06261483,0.008706745,-4.7619142e-08,0.023102531,-0.019457655,0.0046491153,-0.066546656,-0.004971042,0.07686818,-0.007471359,-0.058692634,0.073095284,-0.022536246,0.0074672997,0.018839166,-0.058162127,-0.002331556,0.02486904,-0.030772539,0.003335938,0.07963534,-0.043631136,-0.044476107,-0.03725458,-0.007271639,-0.12595534,0.01940332,0.036090225,-0.06270822,-0.047489528,0.0027643158,0.029835563,0.025476292,0.034743033,-0.006751625,0.051440533,-0.042291384,-0.027201908,-0.015577193,-0.0051714187,-0.03168513,-0.0076606465,-0.095595986,-0.06395995,-0.05956979,-0.0047451337,-0.04413303,-0.05118125,-0.044002622,0.05214599,0.01201774,-0.0293541,0.0038629044,-0.00872117,-0.013698518,0.002143409,-0.07881257,-0.045426704,0.0068260804,0.009088824,-0.08008347,0.0055777677,-0.06970285,-0.022987375,0.031708837,0.10375071,-0.095002025 +6.2.2.3,"Requires Mg2+. The enzyme, which participates in the biosynthesis of some ribosomal peptide natural products (RiPPs) such as the trunkamides, converts L-cysteine residues to thiazoline rings. The enzyme requires two domains - a cyclodehydratase domain, known as a YcaO domain, and a substrate recognition domain (RRE domain) that controls the regiospecificity of the enzyme. The RRE domain can either be fused to the YcaO domain or occur as a separate protein; however both domains are required for activity. The enzyme can process multiple L-cysteine residues within the same substrate peptide, and all enzymes characterized so far follow a defined order, starting with the L-cysteine closest to the C-terminus. The reaction involves phosphorylation of the preceding ribosomal peptide backbone amide bond, forming ADP and a phosphorylated intermediate, followed by release of the phosphate group. In some cases the enzyme catalyses a side reaction in which the phosphorylated intermediate reacts with ADP to form AMP and diphosphate. This activity is also catalysed by the related enzyme EC 6.2.2.2, oxazoline synthase. That enzyme differs by having an RRE domain that also recognizes L-serine and L-threonine residues, which are converted to oxazoline and methyloxazoline rings, respectively.",384,1.0,-0.0628325,-0.13778311,-0.05711434,-0.07465065,0.090777226,-0.030914657,-0.093216985,0.05459255,0.019307759,-0.009323106,0.005809624,0.003230523,0.027857201,0.060480617,0.042483963,0.037855245,-0.04820864,0.04384241,-0.021188105,-0.020515205,0.16403444,0.027898729,-0.064716585,0.03281983,-0.021693388,-0.029927032,0.083762616,-0.0074765976,-0.044090066,-0.010953451,-0.04264783,-0.054874558,0.012474376,-0.028257413,0.017071169,0.11556993,-0.056461193,-0.053735215,-0.0112147415,-0.06658454,0.002125653,-0.016211674,0.06270592,-0.06825249,0.041606486,-0.019109992,0.04170057,0.06408527,0.0085408725,0.009811106,-0.027036967,-0.03540936,-0.043771915,0.051330883,-0.06935391,0.049963124,-0.08680244,0.007782106,-0.015392562,0.021488473,-0.06351723,0.006598825,-0.046245214,-0.024684323,0.09764319,-0.11261563,-0.034270603,-0.037153788,-0.009868936,-0.0061428817,-0.039449733,-0.082045026,-0.03513965,0.045586057,-0.020175627,0.06413477,-0.012326322,-0.0036363818,-0.047011763,-0.029038277,0.055740483,0.012657209,0.043002337,0.067784496,0.025854068,0.016599694,0.00813235,0.060644835,0.057764865,0.042788737,0.11332378,0.023884099,0.01967772,0.026804755,-0.039879907,-0.016549012,0.04366113,0.05033543,0.014408983,-0.037179347,-0.005371747,0.06900917,0.008874764,-0.0341274,0.008631018,0.040813867,-0.03186744,0.102215976,0.015333951,-0.02430164,0.04064096,0.03563175,0.06002612,0.009103688,0.037355125,0.066202976,-0.019226557,-0.08760507,-0.011046163,-0.045233,0.010903112,0.010623046,0.026825042,0.041550834,0.003493231,0.05684167,-0.105817616,3.853215e-33,0.013170047,0.03796446,0.038253274,-0.018061984,-0.043382686,0.024415847,-0.06674958,-0.0011675541,0.0180301,0.02652471,-0.046920177,-0.029895868,0.055433534,-0.015084756,-0.04143515,-0.063871875,0.018309046,0.03181105,0.068383135,0.09353301,-0.037613865,0.06603635,-0.03562044,0.06287906,0.03514556,0.10018341,0.019421516,-0.0843413,-0.012919559,0.007713814,-0.030769987,-0.08350164,-0.11219707,0.03970712,0.06047792,-0.029380988,0.013909952,-0.019585947,0.0013407689,0.008536341,-0.016378952,-0.030687831,-0.03811705,0.02596123,0.036051158,-0.077842526,-0.01164542,0.09232228,-0.044137236,0.06432417,0.115266725,-0.027643787,0.08815277,-0.030152854,-0.057162456,0.012231202,-0.08460276,-0.02017915,0.065773465,0.037836585,0.008554654,0.026707387,-0.057908043,0.07632659,-0.012166241,0.028517561,-0.04959065,-0.18749562,0.023291316,0.11499528,-0.058042485,-0.0071744155,0.093936265,0.027548239,0.019529812,-0.045939997,-0.043367602,0.015503032,0.045235932,0.05468774,-0.056121264,0.039982915,-0.025413457,-0.006902455,0.012000727,-0.022075653,0.047276594,-0.093357064,-0.05596096,-0.014720567,0.032251403,-0.04571683,-0.0050475392,0.096819475,0.039948802,-4.3849323e-33,0.13085143,-0.11652579,0.062613055,-0.055348773,-0.063236736,-0.00026934463,-0.008860336,-0.1061995,0.053805493,-0.13341916,0.019205784,-0.019240472,-0.037546225,0.018406173,0.018421227,-0.06407409,-0.0004500667,0.08375482,-0.034739085,-0.020072537,0.009394854,0.06555974,0.027316775,0.06303741,0.087904334,0.0119555965,-0.024935687,0.073173314,0.064541824,0.026908359,-0.014585533,0.022568507,-0.02539845,-0.031799927,-0.03768155,0.12038377,-0.061797637,0.002756552,0.092378356,0.08885673,-0.0043599713,0.025020014,-0.049148574,0.057550233,-0.01203437,0.02787292,-0.0211626,0.0712516,0.025297308,-0.090724975,0.03952991,-0.040161002,-0.034244597,0.00060677144,0.046014033,0.02435209,0.0041013896,0.020235283,0.019185115,-0.030803697,0.0059346138,-0.04034319,-0.0024784352,-0.013985847,0.0074853892,0.06859211,0.024913631,0.0038453373,0.041689057,0.066408396,0.06143847,0.025326855,0.04484882,0.031292383,0.031217335,-0.027380481,-0.06902728,-0.04433043,-0.009715998,-0.07466243,-0.013435724,0.021836467,0.027013028,-0.02781374,-0.006511344,-0.07041375,0.029952312,0.07741968,0.015816184,-0.05529863,0.000993931,-0.06517732,-0.007148277,0.0884751,0.022996414,-4.8208378e-08,0.039502546,-0.05127484,0.0026340953,-0.094735,-0.0031214666,0.06567266,-0.012893527,-0.043394055,0.052906558,-0.020317744,0.010839353,0.022106031,-0.059220035,-0.0004896584,0.027120821,-0.025157074,0.0058472063,0.07552885,-0.044109263,-0.02638918,-0.027493965,-0.018780695,-0.1348594,0.00952699,0.0042653503,-0.07016816,-0.02504065,0.007016661,0.0023674686,0.026294732,0.032151587,-0.009076292,0.042237926,-0.028279888,-0.030599022,0.007404067,-0.03823814,-0.031840175,-0.012267346,-0.081362225,-0.057095043,-0.04538384,-0.02433325,-0.033001166,-0.037906583,-0.034465767,0.03861,0.015766019,-0.008275635,0.02296502,-0.02652854,-0.025458151,0.005921941,-0.07979016,-0.036117118,-0.00755138,0.012305967,-0.08992334,0.0110964915,-0.084053665,0.0034196628,0.052412137,0.11832138,-0.0895996 +1.2.1.104,"The pyruvate dehydrogenase system (PDH) is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.4.1.27, glycine cleavage system, and EC 2.3.1.190, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3). The reaction catalysed by this system is the sum of three activities: EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) (E1), EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase (E2), and EC 1.8.1.4, dihydrolipoyl dehydrogenase (E3). The mammalian system also includes E3 binding protein, which is involved in the interaction between the E2 and E3 subunits.",384,1.0,-0.043867137,-0.028843202,-0.08812462,-0.13441837,0.107624784,-0.009832602,-0.11527378,0.014369749,0.03409662,0.009184149,0.032619115,-0.056286387,-0.06242897,-0.0065156794,0.022472886,-0.01982976,-0.0936113,-0.046486057,0.0334331,-0.043871585,0.039254013,0.01045877,-0.01468391,-0.006527372,-0.04627526,0.06554268,0.05919805,0.029931631,-0.07056423,-0.08913657,0.037762232,-0.11415122,0.03333583,-0.023163902,-0.0054405,0.11453477,-0.044291023,-0.013296232,-0.019701196,0.052461825,0.026502982,0.04358183,-0.009090231,-0.022390092,0.009080211,-0.019534858,-0.050173946,0.050186474,-0.0058834166,-0.051574487,0.014734507,0.0050308337,-0.028387267,0.079284444,0.038218364,-0.0058352486,-0.035422985,0.081514046,-0.09204783,-0.03592607,-0.0223594,0.021861464,-0.023630792,-0.032692164,0.009312217,-0.024588743,0.0916712,-0.09848653,-0.029056143,0.0065556616,-0.108474895,-0.06287129,0.05259134,0.033851366,-0.031792216,0.08598455,-0.037360165,-0.0051682787,-0.009135738,-0.055057228,0.046717055,0.025085011,0.020239042,-0.012772886,0.0009527033,-0.0029062966,-0.04201518,-0.0731684,0.008484492,0.005521859,0.016018013,-0.05941905,-0.010278924,-0.008593019,0.057698987,0.06600444,0.07349859,0.02048112,0.05439265,-0.06818563,-0.036231253,0.13598621,-0.02620867,-0.061385304,-0.04621557,0.043777123,-0.011306692,0.1313274,-0.009281175,0.0010516052,-0.020478569,-0.023251798,0.017158866,0.015614076,0.03921205,0.08538639,0.048889447,-0.03994848,0.030449739,0.00463122,0.10567429,-0.012566436,0.12351934,0.12124155,-0.036743976,0.03500094,-0.099820465,3.165415e-33,0.02151876,-0.0060543614,-0.038588487,0.0004656903,-0.0058906814,0.025799926,-0.09624046,0.06911672,-0.01355842,0.024897268,-0.09147303,-0.0077580404,0.09865667,0.012317039,-0.04407336,-0.036769062,0.004189768,-0.022946216,0.045696706,-0.017566446,0.028063599,0.06272246,0.004052457,0.03455218,0.03595481,0.07310154,-0.019793823,0.05425424,-0.052053515,-0.027166983,-0.0021701052,-0.106653936,-0.098579615,0.032661293,-0.052972846,-0.030128295,-0.0307292,-0.027376605,0.072339095,0.010032296,-0.011235656,-0.03478177,0.038237706,-0.0319095,-0.013830144,-0.032848347,0.013896037,0.017900543,-0.010972767,0.0084201945,0.06999452,-0.05167815,0.0960284,-0.04552762,-0.08608856,-0.0030641644,-0.04762904,-0.019542363,0.06039238,0.10216062,0.019967834,0.05302473,-0.008536788,0.0004192788,-0.006276887,-0.012781543,-0.08734965,-0.026720509,-0.012239837,0.031347167,-0.044490494,-0.015924359,0.16504474,-0.035137687,0.075154096,-0.006406974,-0.014484867,0.0624378,-0.034191176,0.014776149,-0.057019927,0.033663,0.034874592,0.028799156,-0.04854614,-0.0003471859,-0.028739428,-0.042578567,-0.04438417,0.046474326,-0.019366428,-0.021702688,0.0016184442,0.0148473075,0.07680609,-4.603653e-33,0.07418024,-0.038856126,0.01808112,-0.14335327,0.0007887366,0.12562798,0.05716513,-0.0062407176,0.0002961257,-0.05410948,0.043589577,-0.012776854,-0.028683197,-0.06978726,0.07091542,0.013686099,-0.06898362,0.063136734,0.016511088,0.007958144,0.030479135,0.07837773,-0.04364471,0.016473651,0.08660616,0.038157176,-0.004608564,0.009746148,0.08528501,0.04780248,-0.033908546,0.023605265,-0.048056364,0.08646291,-0.043030158,0.06260756,-0.09343182,-0.017955972,-0.011676224,0.039020266,0.027500495,0.017572135,-0.037583165,0.015656987,0.07927536,0.083450034,-0.029281566,0.014021814,-0.043560635,-0.0043410114,-0.014393524,-0.007892265,-0.049139567,0.026322868,0.050949,0.0885827,0.04797856,0.005989956,0.067624345,-0.031533964,-0.0192408,-0.06607266,-0.005652337,0.04227915,0.01531391,-0.07566996,0.022797855,-0.017177843,0.07426365,0.07738806,0.008928401,-0.008597033,0.018308373,0.01689866,0.019086909,-0.018107418,-0.06845436,-0.042698592,0.0029511966,-0.06790439,-0.015529007,-0.038710825,0.011560119,-0.050938137,0.000452233,-0.0315052,-0.0048781685,0.104360044,-0.007197481,0.004676873,0.03435504,-0.04462228,-0.037805166,0.089174844,0.07420668,-5.0577263e-08,0.08543125,-0.045601476,0.051649798,-0.012914097,-0.00457499,0.0014473014,0.028907424,0.10018859,0.017980142,-0.07300831,0.019520745,0.06302437,0.03571745,0.005530431,-0.033636462,0.03768192,-0.036494944,0.04616055,0.003978274,0.009255816,-0.06733238,-0.04978433,-0.15263954,0.010294416,0.011087439,-0.068268865,-0.025489995,0.021932157,-0.02278341,-0.027083687,0.0116678765,0.010144316,0.007620103,-0.030049056,-0.015832298,-0.0038890378,-0.012580892,-0.025636498,-0.011597141,0.009089797,-0.021848695,-0.0973989,-0.037552636,0.034908816,0.07817831,0.05967516,-0.025849432,-0.004764632,-0.012308972,0.0022086345,0.006636995,0.013865461,-0.014327927,-0.062148556,-0.0850733,-0.033357166,-0.07553249,-0.094242685,0.06419679,-0.07056711,0.025420507,0.049811576,0.114726506,-0.033962317 +1.2.1.105,"The 2-oxoglutarate dehydrogenase system is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, EC 1.2.1.104, pyruvate dehydrogenase system, EC 1.4.1.27, glycine cleavage system, and EC 2.3.1.190, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3). This enzyme system converts 2-oxoglutarate to succinyl-CoA and produces NADH and CO2 in a complicated series of irreversible reactions. The reaction catalysed by this system is the sum of three activities: EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) (E1), EC 2.3.1.61, dihydrolipoyllysine-residue succinyltransferase (E2) and EC 1.8.1.4, dihydrolipoyl dehydrogenase (E3).",384,1.0,-0.057425197,-0.039487876,-0.068935126,-0.09308329,0.116854295,-0.047215305,-0.11677054,0.017437933,0.03697599,0.010623673,0.025116634,-0.038686633,-0.046046533,0.0009607138,-0.006055226,-0.034056164,-0.071439736,-0.016163263,0.0059971125,-0.034886707,0.085649766,0.040967062,-0.03635492,-0.016720217,-0.0009876798,0.048995968,0.0020096474,0.014206176,-0.09055038,-0.12043873,0.045064375,-0.12475997,-0.0033922305,-0.04237531,-0.00963871,0.05825376,0.00364998,-0.029465867,0.008708355,0.07337897,-0.01186442,0.056796663,-0.02848896,-0.038746443,0.03422287,-0.0624074,-0.020550463,0.0116042225,-0.0016086941,-0.019722851,-0.018196765,-0.04580863,-0.020371659,0.04178177,0.06393486,-0.030678827,-0.07698763,0.070736885,-0.06756204,-0.027886651,-0.0028922725,-0.029496461,-0.026012,-0.011508045,0.037934694,-0.036892693,0.092182435,-0.09880985,-0.04016809,0.003639747,-0.11672276,-0.04929577,0.046162374,0.027156545,-0.014431302,0.091262735,-0.05482726,4.4954795e-05,0.012529025,-0.017247014,0.06365701,0.030609444,0.03422091,0.044717472,-0.0010418288,-0.0023668383,-0.008071663,-0.018136669,0.005509386,0.020963734,0.003210274,-0.027948558,0.052173276,0.0051226215,0.05606586,0.07098119,0.07593804,0.057174064,0.028473502,-0.035268337,-0.029390452,0.13229333,0.024962757,-0.07989577,-0.020672018,0.021657942,-0.033753853,0.14530593,-0.014433748,0.005458124,-0.0065074684,-0.045674603,-0.0038389268,0.010473288,0.036920723,0.14063665,0.069441885,-0.021047255,0.031262383,-0.020073876,0.11986553,-0.013214705,0.1280553,0.07803584,-0.004572325,0.042391013,-0.12150457,3.7104464e-33,0.01727744,0.014366228,-0.041748293,0.04691008,-0.01003607,-0.022952722,-0.123515524,0.08255374,-0.00886043,0.040201575,-0.08912938,0.010306115,0.099391066,-0.0063483655,-0.008484078,-0.023602713,0.0018931284,-0.040863544,0.009121499,0.006797239,0.03748368,0.06336469,0.0045442795,0.022086121,0.031039828,0.03978082,-0.00903535,0.021556195,-0.06404864,-0.010972327,0.039859287,-0.12621789,-0.0832287,0.03285155,-0.015342729,-0.07015498,-0.057605308,-0.020743739,0.07331489,0.027804228,-0.0016382728,-0.00914336,0.020882329,-0.03210599,0.024686046,-0.043842334,0.012786771,0.054392967,0.00343019,0.038731102,0.052638903,-0.010617472,0.07484575,-0.04277749,-0.06754856,0.034032803,-0.033394534,0.006637469,0.07908725,0.08317512,-0.030554278,0.04326004,0.010921374,0.02007517,-0.00795376,0.0024993934,-0.097392425,-0.03946091,-0.0018410438,0.039934818,-0.0045200633,-0.023286717,0.14271292,-0.018785998,0.053157814,-0.029404413,0.017189711,0.07292122,-0.026870435,0.027131982,-0.021355087,0.045069367,-0.012443449,-0.00026070751,-0.045579147,-0.009942511,-0.0085461605,-0.040727075,-0.03999479,0.076911435,0.011381877,-0.01591343,-0.02520999,-0.061092425,0.08787741,-3.8205873e-33,0.09810957,-0.06437138,0.02295406,-0.15616518,-0.05539955,0.12102937,0.035923384,-0.057243608,0.016443275,-0.022449585,0.06936642,0.040662445,-0.0022771142,-0.047108013,0.049076334,-0.021141287,-0.07024857,0.007863369,0.03527792,-0.019573677,0.07050548,0.0969975,0.009922876,-0.018912343,0.11303864,0.024993477,-0.024065945,-0.00081977714,0.086949855,0.030754222,-0.06109093,-0.0062272786,-0.019925494,0.07079823,-0.051482417,0.05433373,-0.066625595,-0.025455933,-0.036322452,0.016063206,-0.040070273,0.0037934221,-0.045093853,-0.00409969,0.08225678,0.037138287,-0.0065677413,-0.001576137,-0.026847862,-0.03166286,-0.0030633262,-0.01913563,-0.08152888,0.03650334,0.047973696,0.07612731,0.036064945,0.015016104,0.04907289,-0.02391974,-0.008765573,-0.06412845,0.011297175,0.020251054,0.040351357,-0.06514293,-0.0048148697,-0.0010772492,0.057379477,0.06747916,0.020721368,-0.049520906,0.045251817,0.00087429717,0.05033373,-0.021020409,-0.08270859,-0.021600397,-0.038497236,-0.09343336,-0.027012436,-0.023004858,-0.00017992969,-0.03321964,0.031083288,-0.0543045,0.006306991,0.13063768,-0.017257124,6.968839e-05,0.0195644,-0.007940843,-0.018469477,0.12511824,0.053345043,-4.630948e-08,0.02253551,-0.02696344,0.049356192,-0.0057243044,0.026504796,0.018367922,-0.0029175403,0.077600166,0.014058761,-0.059048753,0.0044619963,0.09762424,0.046454117,0.0063129347,-0.013305022,0.0370053,-0.0528469,0.035688866,-0.015132695,-0.0024095564,-0.041176174,-0.056583054,-0.13840686,0.031385474,-0.0135655105,-0.07118235,-0.029703919,0.011622272,-0.0025472874,-0.023436671,-0.020589862,0.010673701,0.041824743,-0.076131895,-0.051588252,-0.04051998,-0.025120331,-0.0011556833,-0.041702885,0.0030352946,-0.01420472,-0.09004369,-0.025799602,0.060582712,0.069239035,0.041638203,-0.004882507,0.0043185665,-0.034004778,-0.0008073415,0.019035744,0.0014098879,-0.0065423674,-0.02556111,-0.08568939,-0.024542939,-0.02537394,-0.078604594,0.06467302,-0.018567337,0.005158007,0.0571316,0.12388739,-0.033959456 +1.3.8.16,"The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2].",384,1.0,-0.065006085,0.021716962,-0.032956976,-0.056005046,-0.017812325,0.047737602,-0.038494375,0.086412705,0.020240976,0.018422961,0.003548185,-0.046442755,0.04513342,0.027412264,-0.055038735,0.056400042,-0.08124751,-0.015897851,-0.009106468,-0.013474548,-0.094916396,0.06840682,0.015852304,0.025372216,0.028503839,-0.010344637,0.030424673,0.05168454,-0.012890298,-0.024641959,0.09664696,-0.031639706,0.03715208,-0.01650462,0.06709416,-0.05259134,-0.038055673,-0.05265523,0.107533745,0.069203064,0.009112703,0.054714784,-0.048269153,-0.019867806,0.014430377,-0.06227054,-0.0071340413,0.022865266,0.04745905,0.021683922,0.007401133,0.02823265,-0.077167034,0.055398107,-0.007731612,0.009638635,-0.042757425,0.023498394,-0.05396683,0.01346378,0.14567427,-0.008430198,0.09336582,0.04721036,-0.069269255,-0.015972933,0.026057282,-0.06524563,0.015419105,-0.051361833,-0.03660602,-0.10931426,0.00021108458,0.0051789912,-0.0013527469,-0.008710895,0.02498521,-0.027975198,-0.05690215,-0.10307639,0.0684603,-0.06264388,0.055520307,0.020368546,0.009258214,-0.023684792,0.07498535,0.0023036473,0.11267153,0.026849952,0.05669241,0.014314205,-0.032993857,0.0037244214,0.034876596,0.0243623,-0.010072466,0.13204952,-0.032580268,-0.0025517503,0.022456434,0.03169723,-0.06942549,-0.093336545,0.055450592,-0.049826827,0.1021948,0.056242596,-0.054362345,-0.071186095,0.0025871915,-0.086615935,0.060355738,-0.024427313,0.0076498063,0.058976326,0.10907361,0.028314551,0.0018075072,-0.0011492459,0.07724835,-0.002132381,0.05522202,-0.042543225,-0.010976043,0.07316687,-0.060719386,-1.0026169e-33,0.029290505,0.039591257,0.039700016,0.05088915,0.022122,0.0068625477,-0.07682506,0.06168322,-0.09017907,-0.06419651,-0.09306495,-0.009142936,0.06995882,0.029780213,-0.06784891,-0.04497983,-0.0012154509,0.049306918,-0.014675159,-0.07860083,0.04044978,-0.02718019,-0.05331091,-0.017446436,-0.007915573,0.10363575,0.0020976674,0.07061663,0.09645391,-0.030184148,-0.0683803,-0.03380046,-0.107375145,-0.024062196,-0.027091984,-0.005310838,-0.025760144,-0.0012962801,0.06544645,0.030154053,0.009795591,0.026849044,0.009908736,-0.07527326,0.018110458,-0.009330395,-0.087085225,0.078593,0.0824027,-0.0024078293,0.0756342,-0.09516316,0.032431643,0.01990654,-0.013393355,-0.018299915,-0.024989597,0.05763992,0.05881012,0.025389124,0.014588557,0.022398233,-0.07898498,0.007866382,0.06848463,-0.05800659,-0.028785476,0.0227148,-0.072763965,0.002889166,-0.106880926,-0.026848871,0.08017731,0.062203154,0.04348795,-0.061102506,-0.09734498,-0.07711927,0.065533996,0.061847735,-0.06449072,0.011794752,-0.019280808,-0.008923883,0.008063368,-0.06364842,-0.07509842,0.038094964,0.015929533,0.09619367,-0.011346026,-0.0061334483,-0.09360651,0.03709076,0.011482702,-1.8284027e-33,0.04664967,-0.030303044,-0.015818484,-0.024629552,-0.044446707,0.07886509,-0.00742184,0.0008884943,0.070189886,0.050166782,0.15936512,-0.02888408,0.048385933,-0.032201387,0.027308356,-0.05486303,-0.0231953,0.013981746,-0.01301209,-0.022702392,0.023110844,-0.032888662,-0.07367835,0.011080553,-0.023347938,0.029493637,0.08207922,0.011006273,0.057110842,0.06765073,-0.054693885,-0.06832774,-0.0842448,0.060817998,-0.028809577,0.12980673,0.010819904,-0.04337576,-0.024228847,-0.041293375,-0.044023473,-0.017090656,-0.020767508,0.08152918,0.061691348,-0.008182007,-0.00132289,0.014269714,-0.043091394,-0.007528074,0.02263531,-0.00042858085,-0.03125825,-0.001885247,0.0033922282,0.008249255,-0.029212251,-0.026288258,0.027601415,-0.0052838568,0.00051033084,0.011760723,0.02213253,-0.015871216,-0.040627316,0.050180335,-0.07562269,0.09082946,0.03885617,-0.11418161,0.03611226,-0.016612742,-0.06593234,0.02072614,-0.09241987,-0.009472027,0.022122025,-0.072139345,0.04132551,-0.07915804,-0.005792914,-0.03818014,0.038125508,0.036083575,-0.06288454,-0.057293165,0.020228807,0.058875937,-0.025268558,0.001932205,-0.0308575,0.032127522,-0.0024714763,0.0856212,-0.026292644,-3.4642454e-08,0.020156132,-0.050067715,0.11188475,-0.040062048,-0.029898996,-0.012359035,-0.024938475,-0.016514901,0.059141755,-0.08471669,-0.0010738393,0.069188945,-0.018104507,0.04825645,-0.012515157,0.044600148,-0.06025515,0.020661712,8.390812e-05,0.033556644,-0.04268849,-0.02691782,-0.07651562,-0.050751112,0.03215322,-0.054260112,-0.004232135,0.007857225,-0.0620259,-0.03205457,0.040148422,-0.026833523,-0.04479816,0.009777212,-0.044021796,-0.042676717,-0.048054397,-0.07657497,0.019696776,-0.028605517,0.05871143,-0.06289023,-0.11583725,-0.009940645,0.05851344,-0.024176998,-0.053677928,-0.021528032,-0.07232143,-0.05831501,0.018305205,0.010076657,0.0495456,-0.041512493,-0.0131166,0.057965457,-0.009129093,-0.013284423,0.014270319,-0.032187436,-0.06923488,0.014185568,0.12493329,0.006546326 +1.4.1.27,"The glycine cleavage (GCV) system is a large multienzyme complex that belongs to the 2-oxoacid dehydrogenase complex family, which also includes EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.2.1.104, pyruvate dehydrogenase system, and EC 2.3.1.190, acetoin dehydrogenase system. The GCV system catalyses the reversible oxidation of glycine, yielding carbon dioxide, ammonia, 5,10-methylenetetrahydrofolate and a reduced pyridine nucleotide. Tetrahydrofolate serves as a recipient for one-carbon units generated during glycine cleavage to form the methylene group. The GCV system consists of four protein components, the P protein (EC 1.4.4.2, glycine dehydrogenase (aminomethyl-transferring)), T protein (EC 2.1.2.10, aminomethyltransferase), L protein (EC 1.8.1.4, dihydrolipoyl dehydrogenase), and the non-enzyme H protein (lipoyl-carrier protein). The P protein catalyses the pyridoxal phosphate-dependent liberation of CO2 from glycine, leaving a methylamine moiety. The methylamine moiety is transferred to the lipoic acid group of the H protein, which is bound to the P protein prior to decarboxylation of glycine. The T protein catalyses the release of ammonia from the methylamine group and transfers the remaining C1 unit to tetrahydrofolate, forming 5,10-methylenetetrahydrofolate. The L protein then oxidizes the lipoic acid component of the H protein and transfers the electrons to NAD+, forming NADH.",384,1.0,-0.089558825,-0.058622517,-0.115932696,-0.10746784,0.096599326,-0.02074296,-0.07566178,0.02288834,0.03588445,0.045667734,0.023598053,-0.016359076,-0.04830785,0.013378453,-0.064562574,-0.06460183,-0.028954523,-0.02107647,0.024203364,-0.027493814,0.0013530498,0.10232259,-0.021659194,-0.012839033,-0.0115991095,0.04266656,-0.044460133,0.040622283,-0.012091146,-0.08869239,0.025872665,-0.074076205,0.02436629,-0.010347522,-0.027058922,0.1037096,-0.04400313,-0.024679856,-0.010577732,0.045127373,-0.023710323,0.017569091,-0.035039783,-0.024571102,-0.016845113,0.03470045,-0.0016909556,-0.0052890237,-0.023299778,-0.021407612,0.029949239,-0.03642533,-0.073008955,0.04581096,-0.0025561512,0.015443934,-0.11585693,0.020716721,-0.021734817,-0.022994589,-0.016329942,-0.016725246,-0.014447176,-0.019026674,0.030677807,-0.04719113,0.12546629,-0.069550954,0.0054789823,-0.057428155,-0.063115545,-0.029737346,-0.0046475558,0.030479662,-0.09673358,0.10286968,-0.056671824,-0.009202599,0.07004065,-0.0054157986,0.031454433,0.00820789,0.023344522,0.0808632,-0.008837705,-0.0063550128,-0.030410245,-0.0025135314,0.034872714,0.035942603,0.055454347,-0.011708428,0.09390747,-0.023301793,0.07900534,0.060546886,0.080909826,-0.0033680766,0.04313759,-0.061348777,-0.045735676,0.029245388,-0.013553386,-0.039291043,-0.014251124,0.035041213,-0.008253495,0.15601067,0.01140949,-0.02116472,-0.048604555,0.09076118,0.01577176,-0.036803715,0.029671744,0.12568074,0.09787294,-0.0050227386,0.013818284,-0.037341494,0.045489494,-0.014819219,0.10348499,0.066299446,-0.07579158,0.025054835,-0.029074147,3.9488047e-33,-0.008841152,0.025443502,0.02726641,0.04316214,-0.005047545,0.04812131,-0.084627375,0.056512017,-0.0017472049,-0.012167684,-0.09607986,-0.008687985,0.08045473,0.04145927,-0.040078305,0.0016697341,-0.042098988,-0.0526727,0.0049608247,0.0044122534,0.043085642,0.04104639,0.03149719,0.041410245,0.039719272,0.029357912,-0.04144433,-0.008501831,-0.017023312,-0.021362143,-0.03376192,-0.0962401,-0.07539092,-0.0010448287,0.014179597,-0.00095439627,-0.03768394,-0.0507452,0.07519915,0.029213438,0.032248724,-0.045498695,-0.011016763,-0.030886818,0.02185038,0.031657152,0.021219574,0.03990618,-0.051553108,0.0103473915,0.0935743,-0.027088853,0.0006378885,-0.040091995,-0.10117524,0.045168035,0.02339718,0.017725142,-0.016166413,0.12959722,0.0036043678,0.06395,0.009160092,0.0222441,-0.0012473733,-0.063606285,-0.13867429,-0.05147949,0.0156625,0.052324984,-0.008630391,-0.0033917213,0.16681395,-0.047416173,0.045702636,-0.007706163,-0.015098226,0.0063273273,-0.030424442,-0.004565389,-0.067512244,0.055074003,0.032139085,-0.020274105,-0.051746543,-0.04189713,0.00030285362,-0.103962466,-0.043515537,0.005614793,0.0057256385,-0.048522666,0.010171404,-0.04183591,-0.012899236,-4.0222944e-33,0.08793913,-0.064867705,0.013731754,-0.06199959,-0.0055576693,0.059994884,0.074133605,-0.055466503,0.013124544,-0.06662034,0.069742225,0.005156488,0.0064759767,-0.0068230014,0.038423076,-0.012733426,-0.04068729,0.049786728,-0.02323908,-0.04275198,0.027789544,0.054258257,0.036476016,-0.038343728,0.08657348,0.012392859,0.010227932,0.04939435,0.052403435,0.06855718,-0.04702111,0.010116619,-0.025437348,0.06714718,0.024573503,0.059070658,-0.05654301,-0.026850726,0.01328045,-0.01799338,0.0193578,0.034457184,-0.086792015,-0.00361885,0.022746569,0.0914388,0.013597177,0.0339778,0.0070790304,-0.022188654,0.05167433,0.0019737238,-0.07422139,0.1289957,0.059379112,0.06415244,0.026468668,0.033662595,0.036290463,-0.012612489,-0.010552538,-0.038748674,0.029487833,-0.003542438,0.039677694,-0.017005432,0.038444728,0.063171804,0.08448048,-0.0007492311,0.005692508,-0.03206679,0.076773204,-0.012806653,0.012036258,-0.04501223,-0.047177814,-0.044636022,-0.017169783,-0.11451387,-0.015076747,-0.0069995103,0.001048561,-0.05285966,0.09354957,-0.017502423,-0.0049994504,0.16938078,0.035854604,0.060241014,-0.044302173,-0.0043078205,-0.030630998,0.10236673,0.051326565,-4.691383e-08,0.062859945,-0.028307408,0.045339745,-0.014713005,0.039072182,0.06741108,0.022373907,0.044451073,0.0060496377,-0.052819967,0.021790456,0.035971783,0.0031371138,-0.002034651,-0.009879709,0.09056412,-0.12484469,0.040940795,0.0048520346,-0.012896245,-0.09020008,-0.027446216,-0.12912723,0.047665387,-0.04050727,-0.063567266,-0.032834727,0.020620428,0.034366813,-0.06347982,0.019780137,0.038689967,0.017622449,-0.050440975,-0.063354716,-0.0054985383,-0.008867226,0.008752734,-0.0007192702,0.029167524,-0.06336452,-0.0420926,-0.062186208,0.03056718,0.024246711,0.033660855,-0.06614038,0.03986009,-0.024410632,0.06420797,0.0011934988,0.06479068,-0.019128073,-0.0078706015,-0.088447735,-0.06501368,-0.07015391,-0.07436959,0.0010275447,-0.08077853,-0.05715802,0.012374214,0.11782299,-0.056479305 +1.4.3.26,"A flavoprotein (FMN). The enzyme participates in the biosynthesis of the enzyme cofactor mycofactocin. The enzyme uses oxygen as an electron source to oxidize a C-N bond, followed by spontaneous exchange with water to form an alpha-keto moiety on the resulting molecule.",384,1.0,-0.059914183,-0.031674642,-0.15770677,0.056793954,0.075595915,0.00524618,0.035243332,0.04082067,0.027346037,-0.06317243,0.028897636,-0.0076268255,-0.11924247,0.022229718,-0.11154386,0.02124588,-0.047155246,0.0052024303,-0.042483218,-0.029676167,-0.019412277,0.027785106,0.04110938,-0.034723483,-0.041842546,-0.029467667,-0.0027162444,-0.02798399,0.0077728108,-0.02132886,0.08415357,0.035741843,0.06718115,0.017241308,-0.011605863,0.06137281,0.0172762,-0.096882515,0.0079636825,-0.00062586745,0.038531404,-0.018426333,0.023569375,-0.049266357,0.072115205,0.005100525,-0.026903598,0.04057609,0.002426998,0.0818957,-0.044674616,-0.02844529,-0.11228207,0.08056426,0.034606546,0.050155926,-0.027586712,-0.064470425,-0.06435658,0.07842316,0.0014051243,0.041469004,-0.0066562127,0.0348921,0.093250215,-0.08486396,-0.05864325,-0.045627836,0.017273732,-0.007581075,0.0030760407,-0.03990882,-0.07156321,-0.016267965,0.03179138,0.05814939,-0.04632765,0.030955123,0.07615898,0.02137179,0.0642694,-0.00020401814,0.04530474,0.063312106,0.041946106,-0.05783982,0.023095347,-0.029562544,-0.0014156565,0.10485675,-0.04493433,0.006851987,0.005619726,-0.047891017,-0.034530483,0.054742787,0.06444377,0.009304055,-0.038560204,0.04026071,-0.0039464217,-0.0315954,-0.0025858523,-0.027664552,-0.07361804,-0.012640864,-0.022609055,0.04408119,0.09049074,0.0034412416,-0.022769956,0.0058614207,0.026871158,-0.0984411,0.00041103532,0.06013992,-0.029957423,-0.044866886,0.023022734,0.049929485,-0.0221554,0.041372325,-0.024274882,0.117102176,-0.016382266,0.023601606,-0.17491458,9.353081e-34,0.050047502,0.010494226,0.038281046,-0.014079979,-0.040439703,-0.078254506,-0.021515965,-0.046115655,0.00015066822,-0.054486215,-0.074147165,0.030353988,0.024466004,0.009561121,-0.034668885,-0.061453734,-0.038234375,-0.01753751,0.06633441,0.01352431,0.07454906,-0.00090743345,-0.02396345,0.03563559,0.040513415,0.023011466,-0.10233061,0.014041312,-0.039797448,0.027389789,-0.023303337,-0.04001767,-0.05899345,0.0010628807,0.047248803,-0.02483002,-0.023900185,-0.105710134,-0.06281808,0.07276078,-0.0010924854,-0.063461915,-0.05727006,0.011302078,0.06517625,-0.005063046,-0.055738468,0.08723923,0.037206527,0.06839893,0.054967012,-0.06851709,0.06396366,0.038519707,-0.039330058,0.036084075,-0.0148890605,-0.03983042,0.009881019,0.009828232,-0.057669654,0.015383766,-0.028932309,0.09837268,-0.023924505,-0.023914436,-0.012809209,-0.033104155,0.037309535,0.061852947,0.009893553,0.034770872,0.049743645,-0.0030586787,0.034038987,0.009621733,-0.07654365,-0.03240714,-0.048962038,0.018935127,0.07188537,-0.016095703,-0.03590072,-0.04332695,-0.06710332,-0.003081786,-0.038474403,-0.05166024,-0.034239188,-0.046577606,0.03706285,-0.058361787,0.029537382,-0.024835642,0.040217753,-2.3746898e-33,0.035488307,-0.11515788,-0.033680245,-0.0136543205,-0.02575418,0.02023485,0.010122948,-0.05638077,0.026658721,0.027248234,-0.043846488,-0.087436564,0.034253858,-0.04373466,-0.0070154145,0.0017593214,-0.050868943,0.0784107,0.06707889,0.03766711,-0.06424412,0.019366592,0.0571174,0.032251753,0.030841798,-0.0018221429,0.0023678076,0.010541699,0.05092653,0.04762487,-0.09334935,-0.02141543,-0.038579207,-0.060279965,0.05275867,0.07137349,-0.018160798,-0.03270431,0.02231474,-0.027599081,0.024927601,0.03450291,0.065688506,0.04199893,-0.014178734,0.0756897,-0.056426745,0.041043807,0.05304413,-0.014128381,-0.00051172264,0.02755987,-0.044483345,0.08023994,-0.01905008,0.06382369,0.07924414,0.047777805,-0.005915072,0.050869543,-0.02345052,-0.10597646,0.024410298,-0.004285237,0.049414214,0.054750897,0.04148394,0.115183435,0.018021343,-0.0105468845,0.10880913,-0.021958001,0.07917818,0.06970626,-0.0059422874,-0.040295485,-0.004284602,0.082599916,-0.011037502,0.041064724,0.021692306,-0.0002252074,0.0041443645,-0.086492956,-0.022049954,-0.085017286,0.024260597,0.1027423,0.029990721,0.02460986,0.047667142,0.056364305,-0.056981243,-0.05923783,-0.011544486,-3.6824368e-08,0.008023071,-0.08056561,0.05786659,-0.0002738198,0.094847165,0.04137605,0.06354574,-0.04391687,-0.036460266,-0.005938493,-0.0038595728,0.08773901,-0.022143165,-0.045444254,0.056537285,-0.036722258,0.006898132,0.020811813,-0.01601127,-0.02242926,-0.06618262,0.0140003245,-0.06014152,0.024365302,-0.04616556,-0.06479596,0.014264245,0.060567968,0.05975257,0.015068992,-0.005702592,0.06848609,-0.00026405833,-0.06704926,-0.24139792,-0.019398775,0.025385587,-0.054862425,-0.04826501,0.011274054,-0.08097491,0.02201336,-0.01337513,-0.062543154,-0.04874624,0.012733681,0.04740995,-0.016204739,0.030084128,0.043138243,-0.02371657,0.002857077,-0.065536246,0.003506095,-0.052252136,-0.03920357,0.020542491,0.0034833248,0.016913572,-0.07275533,-0.04793336,0.07916844,0.15546447,0.014246171 +1.13.11.91,"This bacterial enzyme contains an iron(2+) atom coordinated by three protein-derived histidines and a Ser-His-Tyr motif. It is similar to EC 1.13.11.20, cysteine dioxygenase, and can act on L-cysteine, but has a much higher activity with its native substrate, 3-sulfanylpropanoate.",384,1.0,-0.04512725,-0.03841149,-0.09364609,-0.006813417,0.1063622,0.046116684,-0.036968768,0.043429974,-0.005474297,-0.043837175,0.040101275,-0.058189996,-0.010664621,0.07378783,-0.031057581,-0.02538479,-0.05816049,-0.009467672,-0.0073151053,-0.0224579,-0.0086700525,0.04295541,-0.009716075,-0.032164853,0.0062324908,0.04189523,0.092802405,-0.0015116793,-0.11242089,-0.02507393,-0.0049939496,-0.10180102,0.107088126,-0.042960335,0.07805292,0.04105744,-0.055134892,-0.060241695,0.049520865,0.025964238,-0.027800975,0.046762455,0.01161959,-0.043324612,-0.016544746,-0.0021242143,0.044192307,0.0056432323,0.07184493,0.0052809925,-0.0459944,-0.018927466,0.03566349,0.037893627,0.05629499,-0.021480767,-0.0371947,-0.035474055,-0.038956854,-0.0076673753,0.033433884,-0.024614573,0.0070694354,-0.021720324,0.012651684,-0.024331918,0.04634143,-0.09013219,-0.021715365,-0.085669495,-0.067968406,-0.04077918,-0.055637904,0.075693585,-0.009688273,0.051732,0.015499549,-0.074722886,0.072199136,-0.023513883,-0.027597407,-0.01676211,0.012914341,0.107866965,0.009863461,-0.04861229,0.021584338,-0.023984559,0.03226633,0.07538851,0.024138711,0.004937931,-0.06647916,-0.102497205,-0.049418602,-0.0038936003,0.0034544687,0.11960923,0.0012369003,-0.020945454,0.017457485,0.07329728,-0.049282998,-0.08080847,-0.036595237,-0.0036946645,0.027342536,0.12917812,-0.014343228,-0.0131300595,0.04903138,-0.014325685,0.032241944,-0.08306324,-0.0005229276,0.12137646,0.0840877,-0.025076509,-0.090585366,0.07044786,0.089580856,-0.02824199,0.061152793,0.06778697,-0.042787585,-0.006149289,-0.12226368,-1.1289649e-33,0.053676195,0.07050649,-0.011402694,-0.017487478,0.02308573,-0.0017410468,-0.09595027,0.047682717,-0.044667132,-0.053093635,-0.08543906,-0.03305176,0.08079549,-0.021946851,-0.07723501,-0.055924073,-0.026891392,-0.040099807,0.09541187,0.02767503,0.057524756,0.06541204,0.059165724,-0.035261117,0.04474263,0.010000529,0.019370085,0.0134834265,0.013312321,0.0051169186,-0.011596082,-0.07116983,-0.10242421,-0.02935312,0.09261334,-0.05165967,-0.04191008,-0.031134317,-0.025097448,0.026593387,0.045280382,0.052430637,0.018952651,-0.025720881,0.030120414,-0.046736717,-0.054234132,0.089266635,0.024773024,0.026077906,0.06559295,-0.022611465,0.062509954,-0.06974611,-0.029813757,0.042294964,0.0003637263,0.037137534,0.07267149,0.097690865,0.036753286,0.071647555,-0.04406899,0.05640628,0.05301527,0.003977321,-0.045839798,-0.016209882,0.0126756355,0.12498351,-0.04840645,0.0018296136,0.062039495,0.017554512,-0.017937753,-0.046982247,-0.14819491,0.011160966,0.084435984,-0.009815646,-0.06101697,-0.05297675,-0.0033873855,-0.013364808,-0.08745123,0.013649601,-0.040495504,-0.025334591,-0.025453774,-0.019426107,0.04546855,-0.09364078,-0.050828394,-0.008255224,0.0041398723,-2.1601226e-33,0.020250453,-0.08568142,0.024464117,-0.10248903,-0.059161276,0.08275855,0.0023990253,0.021116039,0.024532266,0.023456698,0.10571319,-0.037579495,0.01007294,-0.04642128,0.020999195,0.05221222,-0.0065834643,0.067897186,-0.017666092,0.025799137,-0.0047895797,0.0029140536,0.03585703,0.02231405,0.04398314,0.003244961,-0.03801579,0.07658979,0.04793204,0.056602463,-0.04469284,0.01934734,0.018396255,-0.124968626,-0.026965056,0.07181352,-0.05360925,-0.046046928,0.080190755,0.0103638945,0.017240226,-0.027331669,0.033321537,0.13519038,0.019081896,0.07628164,-0.1119011,0.043396886,0.009400084,-0.0386023,-0.029631771,-0.057586007,-0.004311794,-0.00016321373,0.016309934,0.013075096,0.020377817,0.03932844,-0.022064291,0.029355204,-0.010421508,-0.050395302,0.0346445,0.011306774,0.018582176,0.031309288,-0.06744601,-0.054256517,0.025858028,0.011223528,0.018385515,-0.080878325,0.03013355,0.0022190022,-0.045963343,-0.025988242,-0.022696862,0.06402031,0.008969565,0.055399448,0.023846952,-0.045921028,-0.016246248,-0.021817701,0.035020884,-0.09901638,0.025161542,0.066639096,-0.030365871,0.0061820955,-0.04027117,0.028727017,-0.043163694,0.014163623,-0.0054881363,-3.725736e-08,0.03479871,-0.12636632,0.044137746,-0.06022383,0.010109334,0.055517863,-0.009943831,-0.02528371,-0.0003229799,-0.01659467,0.058205582,0.11579591,-0.020463709,-0.03968716,0.04618364,0.012660673,-0.030313492,0.029955566,-0.004174113,-0.0010345853,-0.029004036,0.004828067,-0.067970015,-0.041361284,0.004618779,-0.041562658,-0.02410509,-0.012043969,-0.030584786,-0.03518728,-0.0036278337,0.011831861,-0.0141329905,-0.047599863,-0.09708786,0.014316375,-0.08769565,-0.043478474,-0.0009217079,0.012775823,0.026152387,0.009413127,-0.16082251,0.0058227573,0.017975273,0.026703738,-0.022196604,0.048361845,-0.07017344,-0.023493353,0.025182404,-0.040305194,0.03396487,0.0028100286,-0.055453382,0.06835469,0.013713082,-0.10725306,0.018296847,-0.010951352,0.00407357,-0.020273402,0.12884143,0.002349979 +1.14.11.76,"Requires Fe2+ and L-ascorbate. The enzyme, characterized from the basidiomycete mushroom Amanita muscaria, participates in the biosynthesis of the psychoactive compounds ibotenate and muscimol.",384,0.99999994,0.023018412,-0.049599227,-0.058834687,0.11985674,0.026108809,0.025961913,-0.012186945,0.0604618,0.036528446,-0.043545518,-0.008913592,-0.07720577,-0.03433945,0.017893258,-0.059081417,0.07612275,-0.004339455,0.019756299,-0.0009536,0.017725779,0.12153199,-0.0066561163,0.040124618,-0.0026549033,5.5247815e-06,0.04062294,0.02500183,-0.064955294,-0.04672106,-0.113249265,-0.030912278,-0.014453082,0.1092065,-0.030662399,0.0047519575,0.04648604,-0.05900424,-0.018995222,0.017146304,-0.04104394,-0.035437215,-0.067392245,-0.0025013473,0.01867443,-0.043230664,-0.062441178,0.008954645,-0.029653598,0.02571329,0.040657703,-0.13307515,-0.0117425835,-0.009525459,0.068464525,0.01634472,0.011431794,0.021119881,-0.020903565,-0.0036921913,0.08201957,-0.019466141,-0.009618847,-0.008918376,-0.015478231,-0.00380226,-0.020586329,0.0058746664,-0.06334397,-0.06507506,-0.03163192,-0.016723925,-0.07648871,-0.012303836,-0.016145809,0.03975804,0.06607642,0.0002670803,-0.049631972,0.016870497,-0.008883947,0.03376227,0.025294507,0.037871987,0.017676696,0.049141955,0.05133488,-0.0136503605,0.02567561,-0.043624643,0.11963981,0.025714973,0.012045744,-0.087676294,-0.02064501,-0.019549815,0.026269836,0.052308634,0.028480219,0.0034751224,-0.0077664503,0.0013631346,0.07734562,-0.025196282,-0.022106422,-0.05272313,-0.072694704,0.00794837,0.008549089,0.051448952,-0.029423159,0.008130795,-0.017687434,-0.008359556,0.011735473,0.02073046,0.06185145,0.06104385,-0.013336138,-0.009685662,-0.052547015,0.07323224,0.045791596,-0.018733477,0.05139536,-0.04888151,0.022182638,-0.10178854,3.1479195e-33,0.08314533,0.0192405,-0.06614279,0.07185808,-0.054186776,0.012795193,-0.082643345,-0.023526499,-0.03782871,-0.07498739,-0.07653761,-0.048965096,-0.0012544879,0.06434598,0.027004955,-0.03625432,0.03059781,-0.09737206,0.12137852,0.0018399153,0.05107734,0.011636127,-0.06748846,0.029557867,-0.03702089,0.06638842,0.017003927,0.023649335,-0.0077693104,0.0041671684,0.03751847,-0.029781085,-0.073419124,-0.034141827,0.06827042,9.388041e-05,0.031516723,-0.007030565,-0.05766935,0.0030477885,0.010600522,0.09645186,-0.04091567,-0.01706453,0.08083073,-0.038706943,-0.020994168,0.08986183,0.07878917,0.13700822,-0.0002581389,0.012180158,0.14887707,0.032257035,-0.031250093,0.0862493,-0.04503148,-0.043923084,-0.0028121448,0.035974283,0.04207263,0.01965064,-0.004552152,0.060261752,-0.0077355136,0.016006852,-0.07704977,-0.0016493556,0.016942846,0.057609297,-0.056836564,0.00084880117,-0.02098778,0.028903285,-0.013976562,-0.081853524,-0.12804879,-0.032194808,-0.0415447,-0.004975902,0.028930651,-0.041771006,0.03988095,-0.0028026402,-0.029915793,0.027390473,0.0051587983,0.0033097332,-0.033877216,-0.027993893,0.0056853103,-0.033559244,-0.03547147,0.015763534,0.0509371,-3.2870705e-33,0.123060845,-0.123323575,0.070311174,0.00829179,-0.093656324,0.08680331,-0.03186406,-0.11582587,-0.043796957,-0.014326216,0.03176642,0.015023403,0.07321272,-0.101767465,0.043653097,-0.024898648,-0.033295713,0.06667393,0.025567656,-0.0021207833,-0.037122916,0.13588849,-0.0057706684,-0.013459698,0.07873551,-0.008933026,0.010364525,0.018736204,0.023701008,0.010711617,0.003883621,0.060916655,-0.030612038,-0.11299964,-0.024352847,0.0112950085,-0.052301753,-0.00047185022,-0.041268613,0.018185213,-0.03112266,0.10118487,-0.012335189,0.07549824,0.024781955,0.04777186,-0.04313459,0.030193577,0.045822084,-0.022458654,-0.0047528786,-0.08997656,-0.047325622,-0.087735154,0.02475604,-0.07880349,-0.011672722,-0.03292553,0.006507548,-0.03801793,-0.036348373,0.0060120607,0.029376723,-0.058818553,0.072753936,0.044385787,0.01918309,0.060451332,0.07081396,0.010266703,0.11164459,0.0346801,0.027904475,0.054693393,-0.003235933,-0.008389889,-0.101162806,0.024707012,-0.012780003,-0.019899346,-0.0010600017,0.02851091,0.0094384495,-0.06225796,-0.081096016,-0.072101876,0.015702022,0.05541157,-0.070785366,0.023460858,-0.061002295,0.0035698,-0.02253524,0.014177074,0.028030494,-3.417818e-08,-0.007012807,-0.041746136,-0.008521248,-0.023543702,-0.0056079966,0.010353862,0.026309947,-0.014494066,0.010729584,-0.0387949,-0.041064266,0.082299605,0.075564176,0.10629759,0.0130934,0.0007504453,0.11306093,0.06090493,-0.011395857,0.0741755,-0.07605795,-0.030783752,-0.10481905,0.03251793,0.0013971693,-0.07365539,-0.029076288,0.013896789,0.07552685,0.023225265,0.0072492664,0.009611158,0.066148646,-0.08025761,-0.104793064,0.0070966105,-0.06287715,-0.0969765,-0.008666876,0.008787931,0.07263958,-0.070674986,0.043312754,-0.014441315,-0.0899076,-0.038214624,0.0062421546,-0.0067760884,-0.0011186259,0.009357823,0.041697673,-0.0042877826,-0.0020340092,0.02014884,-0.03478454,0.042230107,0.1065256,-0.012323987,0.085733905,-0.10363728,0.03916718,0.0012704262,0.09224047,-0.08169486 +1.14.15.38,"The enzyme, found in members of the Sphingobium genus, initiates the degradation of N,N-dimethyl-phenylurea herbicides by mono-N-demethylation. The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyses the monooxygenation of a methyl group. The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde. The enzyme associates with additional proteins (a reductase and a [3Fe-4S] type ferredoxin) that are involved in the transfer of electrons from NAD(P)H to the active site.",384,1.0,-0.053220794,0.016147263,-0.09720597,0.0438766,0.1308469,0.027123319,-0.008585948,0.0018426705,0.014254117,-0.07317275,-0.011795629,-0.011278963,-0.031680558,-0.030477105,-0.05122058,0.05334767,-0.08723773,0.023837833,-0.0012754025,-0.0066536735,0.012837735,0.02724386,-0.02400155,-0.021922152,-0.015407284,0.00041892173,0.051824618,-0.019613456,-0.045320638,-0.07608017,0.08650574,0.08586591,-0.016123336,-0.07280107,0.017367514,0.13302344,-0.011941688,-0.016246514,0.03725997,0.024244716,-0.02713441,0.041510757,-0.024268184,-0.09745864,-0.0663718,-0.06311505,-0.009276932,0.022174478,0.03431861,-0.039459363,0.029744145,-0.05122521,0.015870212,0.083816975,0.049058706,-0.03253839,-0.037662808,0.049350496,-0.08892827,-0.00330482,0.024299668,-0.0043953597,-0.017738357,0.009694154,0.007884642,-0.04752216,0.042766027,-0.07980688,0.014900359,-0.0425021,-0.06048931,-0.03459314,-0.027389927,-0.043355804,-0.006818488,0.03364567,-0.0035055347,0.024163987,0.07824301,-0.10125217,-0.010375315,0.043835063,0.07139943,0.04609706,0.06897683,0.02270592,-0.04346329,-0.004397481,0.06690895,0.028762208,0.0003816927,0.06796024,-0.008879326,0.003217358,-0.081664905,0.08576124,0.0026778972,0.058202762,-0.011751314,0.05669544,-0.030396918,0.08431939,-0.0462957,-0.10479716,-0.03810487,0.06982003,-0.030273195,0.128223,0.045338504,0.027574303,0.002554267,0.018025476,0.084508136,0.0011838732,-0.045975316,0.03760566,0.0060898517,-0.033672962,-0.068064496,-0.078339115,0.042839903,0.010646747,-0.02300898,-0.014965108,0.006829194,0.037510023,-0.11244178,2.0929657e-33,0.13057455,-0.024470588,-0.006270888,0.011341921,-0.034577165,-0.015915658,-0.06958205,0.009060391,0.011040902,0.0030382334,-0.061308336,-0.12775578,0.006266304,-0.072146334,-0.037095275,-0.0326522,-0.045081306,0.03422754,0.0501768,0.0051737158,0.0124829775,-0.011163561,-0.12275483,0.005633964,-0.002678009,0.04744285,-0.042984083,-0.028015617,0.009991452,0.006406524,0.04892984,-0.023424981,-0.1425862,0.013186053,-0.024176443,-0.050950512,-0.015644131,-0.0021421988,-0.010342278,0.01012719,-0.02670551,0.056884155,0.035221744,-0.056046505,0.07213551,-0.056461435,-0.079821125,0.118788145,0.040895436,0.10934846,-0.0020063315,-0.07804298,0.12460363,0.060982984,-0.07246993,0.06759304,0.021947037,-0.06111563,0.05350108,0.04541328,0.03118765,0.060841557,-0.02752057,0.018032763,0.043621432,-0.03638698,0.015668524,0.047218263,0.0042855395,0.058528922,-0.026855044,0.04616202,0.028173896,0.041584868,-0.001196111,-0.11077651,-0.027682088,-0.06532915,0.07162065,0.07804485,0.042015616,-0.016633667,-0.043417197,-0.08677465,-0.032591686,-0.0034263055,-0.026386714,-0.077381775,-0.048115276,-0.025887959,0.06089487,-0.04035739,-0.08371496,-0.06991764,-0.039868526,-2.6953641e-33,0.060641628,-0.020751853,0.021326248,-0.0375085,-0.051990006,-0.007501654,0.018551597,0.031830594,-0.045839436,-0.043562815,0.07481617,0.04570927,-0.009500554,-0.01405061,0.06661962,0.04123034,0.014019111,0.025249103,0.041079994,-0.05687042,0.03219782,0.075445086,-0.0635382,0.043880127,-0.008999764,-0.054093927,-0.04311651,0.058660872,0.1280911,0.08531251,0.016271394,0.017083367,-0.06023384,0.020432629,0.065121606,-0.014248083,-0.046601452,0.01718352,-0.0017953928,-0.04800124,0.026851574,-0.016481908,-0.013591891,0.12966076,0.08227852,0.04754371,-0.16556956,0.016337538,0.011459272,0.0063678604,-0.0017072547,0.017851561,0.0102262255,0.0046859863,-6.641554e-05,0.0287241,0.031379387,0.0127396,-0.04538683,0.023251204,0.012423987,-0.023331577,-0.015754791,0.112261236,-0.023176486,0.08073822,-0.038934305,0.087815754,0.012173721,0.026666218,-0.0074971654,0.01833132,0.020590978,0.008261386,-0.06891414,-0.08908095,-0.00521255,0.051589698,-0.015787432,0.025862802,0.057546623,0.013573059,0.049146898,-0.08059344,0.03833918,-0.08016543,-0.014148295,0.022013769,0.02605661,0.0013227378,-0.054702472,-0.024676057,0.02686229,0.021063196,0.006954702,-4.7393275e-08,-0.048497654,-0.07135764,0.07183197,-0.058377203,0.035230048,0.000103413084,-0.015635317,-0.029513313,-0.0026249525,-0.064342864,-0.0104522575,0.122081846,-0.04163844,0.036960248,0.059760083,0.034396384,0.008350477,0.012067258,-0.06556631,-0.026216008,-0.037009493,-0.0013094263,-0.11909588,0.027119078,0.04299547,-0.025421534,0.014527434,-0.004154152,0.055463824,-0.020691104,0.017591003,0.060761943,-0.00972172,-0.0005500493,-0.070594326,0.009463775,-0.052540623,-0.013374796,-0.00089330046,0.022557909,-0.0646336,-0.019497646,-0.0484332,-0.027372805,0.024017105,-0.02520035,-0.00066513865,0.0017293665,-0.012954702,0.008962647,0.06540092,0.015167794,0.013301759,-0.04827307,-0.112847336,0.07004652,0.0049054273,0.03070694,0.06320556,-0.072492585,-0.045254577,0.030850621,0.13521852,0.012397202 +1.14.99.67,"The enzyme, isolated from the bacterium Streptomyces venezuelae, is involved in the biosynthesis of the antibiotic chloramphenicol. It contains a carboxylate-bridged binuclear non-heme iron cluster. The components of the native electron chain have not been identified, although the immediate donor is likely to be an iron-sulfur protein. The reaction mechanism involves formation of an extremely stable peroxo intermediate that catalyses three individual two-electron oxidations via a hydroxylamine and a nitroso intermediates without releasing the intermediates. cf. EC 1.14.99.68, 4-aminobenzoate N-oxygenase.",384,1.0000001,-0.061674975,0.01933011,-0.11276304,0.022254162,0.05358884,0.027769784,-0.05743088,0.04937657,0.08142358,-0.06321425,-0.0037546093,-0.051770877,-0.007841987,0.052845474,-0.10315099,0.04314332,-0.08041307,-0.0122853,0.03891303,-0.026735218,0.026653364,0.025787039,0.02557283,-0.08092188,0.010801257,0.108527504,0.061075862,-0.043845773,-0.042774666,-0.09261992,0.042120297,-0.041181352,0.08508447,-0.07555944,0.068591475,0.06621229,-0.008560471,-0.110951126,0.03239962,0.017039362,-0.043184042,0.03989631,-0.032893267,-0.014296477,-0.04430913,-0.018772375,0.11714406,0.0580325,0.03360974,-0.056871105,0.008824545,-0.07736068,-0.024252912,0.032085832,0.000960349,0.07448651,-0.0036180445,-0.057227094,0.010013633,-0.06444167,0.06713897,0.03735594,0.002631463,-0.0026626464,-0.082186274,-0.020734478,0.039111104,-0.07778643,-0.012150238,-0.10163419,-0.07984858,-0.04514834,0.0028099727,-0.018548349,-0.025337324,0.0065504387,0.06582833,-0.05644769,0.030645976,-0.003165988,-0.022578515,-0.052294936,0.0039436375,0.109466165,0.07506766,0.0128748305,0.03924929,-0.009683984,0.029153122,0.030391322,-0.012910578,0.014253307,-0.0073084,-0.018799642,-0.06929475,0.029151611,-0.014170695,0.12625994,0.01256009,0.0060066218,0.045910694,0.07353332,0.023443429,-0.060808245,-0.02004306,0.019293558,0.009547989,0.1404555,0.08868078,-0.04843404,-0.0208052,-0.0046941047,0.01405507,-0.022917701,-0.026706785,0.096063785,0.07995879,-0.041620474,-0.067991175,0.043857433,0.038726885,-0.015701154,-0.011976169,0.03029919,0.010320222,0.05920749,-0.11314427,1.8198469e-33,0.045923565,0.032029003,0.022176266,-0.04450043,0.018205572,0.0022350652,-0.10858408,-0.013274856,-0.022957109,-0.03744782,-0.08672346,-0.0699159,0.057591747,-0.050269246,0.0031623722,-0.0698644,-0.035819538,0.011768889,0.06739951,0.01812928,0.0139244115,0.049870316,-0.034670684,0.02424461,0.022289302,0.07738319,0.029185932,-0.005745109,0.05766972,-0.021387277,0.046941392,-0.031350173,-0.09694213,-0.042679496,0.06428679,-0.012857093,0.0044195526,-0.017009223,0.00477308,0.034233194,-0.04377403,0.06908212,-0.018323932,-0.02366025,0.0907187,-0.08769875,-0.082514115,0.10412087,0.053215038,0.06752003,0.0027720903,-0.028846426,0.08641415,0.004052519,-0.07159007,0.074791715,-0.040143605,0.059937328,0.09290726,0.046390697,0.030952636,0.09702313,-0.04808604,0.025481537,0.04992856,0.047825817,0.0034876636,-0.001619463,0.029806387,0.046513505,-0.10296021,0.028097812,0.021830956,0.04952531,0.03197201,-0.049734708,-0.10223385,-0.025179338,0.108980976,-0.0022244367,0.020720262,-0.02689801,0.0414169,-0.081616715,-0.049170002,0.036844708,-0.047559116,-0.029684963,-0.033088062,0.08078304,0.026442865,-0.091584474,-0.08256472,-0.04920282,-0.016274218,-2.5126478e-33,0.09045011,-0.10587584,0.03215538,-0.089411594,-0.039541997,0.047443397,-0.08814631,0.0040107034,-0.018311126,0.011052115,0.07335711,-0.0014376764,0.035006322,-0.054758955,0.05916668,0.022868091,-0.03971975,0.08369711,0.03238225,0.035569455,0.01809668,0.04974963,0.004316572,0.02632186,0.0047403113,0.010271571,-0.031437322,-0.0079583535,0.10359929,0.024197336,-0.030074883,-0.016726095,-0.0020873868,-0.050923374,-0.016794747,0.04503016,-0.08154153,0.049308326,0.11333957,0.00227436,0.015174807,-0.023261026,0.0058970256,0.05192381,0.004032967,0.070275776,-0.13494678,0.015191334,-0.021316094,-0.061769746,-0.03181999,0.036097024,-0.04260457,-0.027504575,0.023711763,-0.006786525,0.026293572,-0.0045684995,0.017754786,-0.030943565,-0.047933556,-0.05146823,0.04153252,0.004161042,0.06490477,0.010172817,-0.055052806,0.065225616,0.07767377,-0.052441332,-9.4238865e-05,-0.017233808,-0.003342964,-0.009584677,-0.023327092,-0.023946136,-0.054470986,-0.012141976,0.02031003,0.0051562204,-0.006290365,-0.011610566,0.058580127,-0.08167106,0.0019592443,-0.12697147,0.053733103,0.033113457,0.01475546,0.018795025,-0.026851675,0.03222886,-0.007121339,0.011582358,0.013423395,-4.3156252e-08,-0.00542513,-0.045851298,0.08545898,0.0026707256,0.028043358,0.024658453,-0.003128753,-0.038387913,0.028658904,0.013224549,0.01996198,0.07068301,0.0090052085,-0.046110053,-0.036508493,0.07077154,-0.027902227,0.00029403367,0.015681723,0.042737544,-0.0809325,0.035054065,-0.073878944,0.057183098,0.018912897,-0.06988853,0.06748352,-0.015302852,-0.00957703,-0.042198125,-0.056896828,0.041263465,0.004802709,-0.046242137,-0.04989734,-0.0350579,-0.05864979,-0.04006182,-0.019426854,-0.015054013,0.026336014,-0.02281012,-0.045066755,0.008050037,0.008751698,0.031140275,0.008064493,-0.02567572,-0.059866477,-0.036830094,0.09229465,-0.03421623,-0.0074417056,-0.035962824,-0.11566867,0.101234004,0.0021536842,-0.056623552,0.0033003974,-0.023300225,-0.030379124,-0.026760362,0.12227144,-0.023276646 +1.14.99.68,"The enzyme, characterized from the bacterium Streptomyces thioluteus, catalyses an early step in the biosynthesis of the antibiotic aureothin. It contains a carboxylate-bridged binuclear non-heme iron cluster. The native electron donor has not been identified, but is likely an iron-sulfur protein. The reaction mechanism involves formation of an extremely stable peroxo intermediate that catalyses three two-electron oxidations via a hydroxylamine and dihydroxylamine intermediates. cf. EC 1.14.99.67, N-[1-(4-aminophenyl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide N-oxygenase.",384,1.0,-0.054817133,0.02775239,-0.10914258,0.03702997,0.07810416,0.0101786,-0.050923448,0.055368487,0.045781158,-0.04492552,-0.03392667,-0.08022308,-0.027492084,0.038822707,-0.09472009,0.045405917,-0.06784399,-0.04590486,0.048981737,-0.00077864516,-0.00800657,0.054288205,0.017787265,-0.042950287,0.04619168,0.09370712,0.051223665,-0.023762925,-0.060118765,-0.049133264,0.03679181,-0.07885542,0.064815134,-0.021051472,0.05783413,0.058080204,-0.010796245,-0.06182411,0.05303933,-0.039172515,-0.042109784,0.027510712,-0.006126676,0.0032347902,-0.04422388,0.0068147588,0.09346034,0.058733355,0.04427539,-0.01844071,0.0067241024,-0.026322592,-0.03126801,0.05922691,0.011222056,0.08111292,0.00019534436,-0.05458821,-0.008720552,-0.05109388,0.058764607,-0.018431112,0.008672934,-0.016552914,-0.06688807,-0.031125199,0.007819095,-0.074681155,0.0042905123,-0.10248178,-0.031349283,-0.015626047,0.021665711,0.00034180045,0.011722915,0.036466688,0.017942023,-0.03793276,0.055607792,-0.01037903,-0.0183512,-0.04383276,0.013331291,0.16280016,0.043985516,-0.038219184,0.03198572,-0.031409014,0.002149678,0.025792887,-0.0006997152,0.010458725,-0.025775596,-0.035101242,-0.056309126,0.028027324,0.006192311,0.0880031,0.050950676,0.028227065,-0.021396078,0.08251995,-0.011148255,-0.07015095,0.0037917546,-0.014044069,-0.015506435,0.13112849,0.0805887,-0.041237906,0.03067343,-0.02400843,0.042301454,0.032211483,-0.006290912,0.0845526,0.074151434,-0.06700009,-0.076571375,-0.02995622,0.029470457,-0.00048538562,0.02377563,0.029535053,0.0022363372,0.005444556,-0.10976454,2.8649637e-33,0.03752892,0.060531706,0.015191538,-0.03838013,0.038109463,0.003969306,-0.1314945,0.008333461,0.018361993,-0.0015062258,-0.09927954,-0.09444173,0.06609778,-0.007025011,-0.03064791,-0.12300273,-0.010431662,0.021728255,0.057188593,-0.004786183,0.033133317,0.051726487,-0.008256476,0.0054914784,0.013210022,0.110727616,0.06818962,0.043188754,0.061063703,-0.02039337,0.046518408,-0.0573402,-0.0779161,-0.069870576,0.03812977,-0.03341352,-0.03528843,-0.01280039,0.012467298,0.037714206,-0.023392351,0.07968768,0.01173724,-0.071288005,0.09867048,-0.082568526,-0.062345807,0.09114715,0.016985014,0.08643592,0.018506365,-0.06802528,0.09477377,-0.02645802,-0.057633977,0.02853276,-0.025733184,0.05225579,0.09651229,0.043091703,0.04470489,0.060810726,-0.05357881,-0.003916191,0.010708805,0.032891512,0.019508116,-9.4372954e-05,-0.012667795,0.072818905,-0.042982027,0.04853529,0.039379764,0.0147030065,0.017395444,-0.026178012,-0.070512064,0.026600486,0.097996764,-0.032093663,-0.0074955253,0.020027533,0.016111115,-0.040027812,-0.032246098,0.017026572,-0.07344305,-0.05663566,-0.038975928,0.04998212,0.021700278,-0.10447769,-0.09644099,-0.021996778,-0.040921785,-3.4002133e-33,0.08444223,-0.11444481,0.02646097,-0.0868747,-0.0021746524,0.062735245,-0.07737957,0.031717625,0.028102633,-0.004394479,0.098597735,0.009167873,0.03732306,-0.06496646,0.054509345,0.0065327683,-0.0010972396,0.046356924,0.033716947,0.02719472,0.05379739,0.045620278,-0.038340665,0.023900224,0.045229446,-0.010990484,5.2827403e-05,-0.008897967,0.09744755,0.08389356,-0.020888222,-0.005359985,-0.021806745,-0.06704149,-0.029001089,0.08344984,-0.059924327,0.031298064,0.058719803,-0.001516768,0.049462724,-0.030890705,-0.0050238525,0.06964294,0.008587122,0.06729804,-0.14758971,0.021083131,0.015127989,-0.029772555,-0.010449003,-0.022587502,0.007450164,-0.039214343,0.011927786,0.026713628,0.02484942,0.0053197686,0.042002756,-0.032966845,-0.048466228,-0.080505915,0.08646914,0.003153627,-0.023467313,0.020949718,-0.096255995,0.05407764,0.053708825,-0.036797162,0.027169285,-0.013565161,-0.02916684,-0.014632245,-0.016414365,-0.012354169,-0.02649072,0.009147416,0.022118792,0.03231345,-0.00028401028,-0.013102535,0.03066632,-0.038681883,0.00063612574,-0.087095186,0.04418147,0.077604935,-0.038044,0.041566152,-0.03768933,0.042655222,-0.008825182,0.0020942213,0.005395569,-4.5488562e-08,-0.022917386,-0.053342015,0.09082317,-0.009773284,0.008952651,0.034646425,-0.0023371307,-0.014498166,-0.018756079,-0.03235018,0.006909752,0.10146396,-0.03913351,-0.06446419,-0.069314286,0.061172802,-0.05110835,-0.016190521,-0.0073265666,0.02160899,-0.063530214,0.027906165,-0.06840167,-0.005737398,0.03787086,-0.0654442,0.028807824,-0.06226717,-0.04345808,-0.0638286,-0.014045833,0.067256615,-0.02910814,-0.051925343,-0.052379493,-0.03419524,-0.054775946,-0.05049604,0.00058576587,-0.038100466,-0.00084154,0.038424745,-0.063701816,-0.0052465927,-0.028071932,0.046691332,0.009961587,-0.003048754,-0.10900218,-0.029788364,0.13248214,-0.038633052,0.0076462836,-0.041116107,-0.1313065,0.09975924,-0.0034043745,-0.07673957,0.010232215,0.004108987,0.0026499482,-0.03223365,0.1518595,0.008237352 +1.14.99.69,"The enzyme, found only within a small subset of facultative anaerobic bacteria, belongs to the nonheme diiron family. The enzyme from Salmonella typhimurium was shown to catalyse a stereoselective (E)-hydroxylation at the terminal C4-position of the prenyl group.",384,1.0,-0.04057225,-0.025653746,-0.03947321,-0.0038758372,0.0767637,0.051438134,-0.037042264,0.050242584,0.06973067,-0.007677304,0.029327389,-0.09340185,-0.02309009,0.08333925,-0.039196208,0.030797755,-0.091347784,-0.03182058,-0.030786905,-0.026756942,0.021413907,0.0028926544,0.031212846,-0.009300676,0.0080861505,0.04244672,0.078352146,0.039546784,-0.037284106,-0.056441702,-0.0087837,0.03707148,0.12792501,-0.035395425,0.06080606,0.10924205,0.022805829,-0.034075815,0.1475967,0.02578736,0.025256855,0.08506319,0.041023508,-0.033894096,-0.021944566,0.0005059562,0.08025897,0.046619248,0.06249778,-0.011715189,-0.05671991,-0.04070151,-0.009769089,0.0170618,0.041284002,0.035963356,-0.015950467,-0.096253365,-0.02747776,-0.023376996,0.10327852,-0.007854684,-0.0070426706,-0.010248881,-0.0670994,-0.05526682,0.07737966,-0.049269293,0.011618211,-0.05745245,-0.043942347,-0.0330973,0.00800563,0.020053029,-0.037212946,0.08027618,0.032282483,-0.05149808,0.030443382,-0.06305501,-0.00500471,0.052104067,0.033993937,0.08505735,0.048293542,-0.007376079,-0.046909798,-0.03173409,0.07825414,0.024160571,-0.04621829,-0.010877006,0.0041668275,-0.095314965,-0.06602873,0.0018737881,0.0263719,0.031865735,0.039345596,0.012948012,0.03753465,0.04579607,-0.055044256,-0.07574318,-0.014399569,-0.031150801,0.058690477,0.1514223,0.029320316,0.001835339,-0.020892339,0.012212327,0.052419715,-0.011338679,-0.07186436,0.069503605,0.0062339054,-0.08919809,-0.067638,0.028594008,0.0008149402,-0.08137967,0.045215946,0.042778317,-0.018656844,-0.011430215,-0.08651706,3.2674893e-33,0.08206019,0.03418646,0.040155113,-0.03599471,0.030105082,-0.0022963951,-0.07447727,0.0004945152,-0.021567816,-0.024074025,-0.08683601,-0.016112922,0.0046196263,0.017108234,-0.089014724,-0.048167344,-0.03044452,0.0055323904,-0.016775412,0.017796021,0.007042508,0.063411966,-0.032364696,-0.06546354,-0.018704467,0.03712466,-0.024890523,0.016876768,0.08584021,0.007102778,-0.00700619,-0.06619281,-0.07387347,-0.019698855,0.076446265,-0.0068957997,-0.058610033,0.025813533,-0.029360661,0.083447985,-0.011712609,0.068414025,-0.013146571,-0.06581757,0.053466473,-0.07840232,-0.036530558,0.06898379,0.032057595,0.059465617,0.030918166,-0.0022998445,0.10671524,-0.07442998,-0.053320244,0.009353725,0.030701155,0.05332398,0.0755338,0.015787587,0.014592105,0.06493651,-0.09531558,0.055236522,0.02062236,-0.019509276,0.03561466,-0.04372588,0.049575046,0.1127539,-0.028512653,-0.03169993,0.014999012,0.03823572,0.00844935,-0.020962883,-0.10395393,-0.030229883,0.04075314,-0.05242808,-0.050977707,0.0048704674,0.01394809,-0.051922802,-0.06984847,0.0459564,-0.01602762,0.01611932,-0.0058679143,0.029966231,0.012217492,-0.05446725,-0.08418632,-0.026034987,0.01223057,-3.4907455e-33,0.04890197,-0.048255045,-0.0054803723,-0.14565049,-0.09131922,0.08217402,0.011715328,-0.024853824,0.021015257,0.020325607,0.08135698,0.002457171,0.00852422,-0.02501292,0.019537352,0.022881327,0.019964818,0.04172433,-0.01986179,-0.0056961025,0.031746127,0.009226316,-0.057946466,0.007123638,0.0045738434,0.050864276,-0.018141953,0.12744486,0.030742902,0.06560334,-0.066704676,0.017940896,-0.010690177,-0.05651684,-0.010544728,0.058203176,-0.09929553,0.020336501,-0.019853352,-0.0071160365,0.016529163,0.012735097,0.012896665,0.09954433,-0.0014420504,0.080131225,-0.10106369,-0.025421698,0.028650904,0.011945326,-0.010973237,-0.029121352,-0.0024305184,-0.035451654,0.05263888,0.019280832,-0.029705761,-0.008625674,-0.027791217,-0.07218982,-0.052026726,-0.06818757,0.0835893,-0.026370516,0.015501658,0.048162717,-0.05882567,0.0926721,0.036467392,-0.008201443,-0.011250026,0.04498559,-0.013324691,0.0071433955,-0.058723636,-0.0010201049,-0.041385937,-0.039176315,0.034298737,0.017333051,0.013288718,0.008346924,-0.06561027,-0.06922126,-0.025407195,-0.06872822,0.045914646,0.07550686,0.012034714,0.055391688,0.056738976,-0.010063974,-0.011154911,0.028911417,0.055045236,-3.9489954e-08,0.013799857,-0.08236906,0.122782126,0.020047147,-0.048567124,0.009285157,-0.018141873,-0.037007693,0.06406707,-0.0370689,0.0147415595,0.08105698,0.03276084,-0.06768696,-0.0117987525,0.032433957,-0.02779934,-0.04022567,-0.049335238,-0.014709779,-0.04149722,0.006191481,-0.060077503,-0.009131829,0.06556644,-0.05774656,-0.023962425,-0.056491386,-0.03802994,0.0028950372,-0.019596497,0.020927478,-0.055563357,-0.039975367,-0.07766873,-0.03460695,-0.0920129,-0.044399314,-0.09742742,-0.023256993,0.052515417,-0.010970043,-0.14793101,0.004501194,0.01672904,0.067858316,-0.034009226,0.031164955,-0.0015703633,-0.014838211,0.04632964,-0.039076492,-0.002890654,0.0076413243,-0.13627717,0.051964063,0.0058573144,-0.02665586,-0.083208695,-0.056132037,0.014868293,0.047128182,0.17964925,-0.024148706 +1.17.98.4,"Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1].",384,0.9999999,-0.0324189,0.030093208,-0.073330924,-0.0037589534,0.047629442,0.0020049263,-0.09526018,0.03636477,-0.0020034262,-0.055857748,-0.01593713,-0.02526544,-0.074647315,-0.0014937214,-0.045289487,0.0038743943,-0.10928017,0.002930987,-0.02067973,-0.11005467,0.061898023,0.05611054,-0.03345333,0.012672094,0.031331476,-0.016694754,0.05475579,0.021565445,-0.05124518,-0.08213115,0.009699314,-0.075323395,0.099905066,-0.019667806,0.03409989,0.083487384,0.04786518,-0.072483785,0.04176183,0.023023972,0.046026655,-0.0015446353,-0.03731371,-0.067791305,-0.06130718,-0.018256005,0.040022727,0.012800105,-0.022113943,-0.0014235395,-0.010831104,-0.06166789,-0.0818448,0.018705899,0.009267822,0.052582357,0.036286656,0.03046361,0.0014998568,0.022611957,-0.033005532,0.017719751,0.015830623,0.014741608,0.012132317,-0.031843293,0.09579946,-0.048811562,-0.026554165,-0.119518556,-0.052657943,-0.033479173,-0.07294862,-0.0046301004,-0.09585205,0.019327601,-0.042020753,-0.038613606,0.053214602,0.042365164,0.06130187,0.02000527,0.097750925,0.076334596,0.05605361,-0.015961774,-0.007153113,-0.040548142,0.018313373,-0.040529158,-0.016857497,0.0020020076,-0.07407592,0.011661007,-0.03486884,0.084218025,0.13128829,0.0853003,0.04907784,-0.0021411218,0.0013525202,0.05517141,-0.03480096,-0.06812571,-0.035497714,-0.024177842,0.039455604,0.11855375,-0.033449877,-0.004491099,0.048632413,-0.03429245,0.022098152,0.015436754,-0.012024449,0.062600784,0.017145326,-0.006321479,-0.046769477,0.012381677,0.04225978,0.016038574,0.015701093,0.006380221,0.0083185155,-0.00011447294,-0.06601399,2.92945e-33,0.03828865,0.009599566,0.0004951805,-0.007800925,-0.029794628,0.01021583,-0.120150685,0.055893254,-0.0029453556,0.013000811,-0.04795117,-0.01746015,0.06942759,-0.04988859,-0.029954642,-0.028239833,0.014601874,0.04118356,-0.025960578,0.065898806,0.017593248,0.06492746,-0.014582085,-0.0029129556,0.020717641,0.058914505,0.019606607,-0.041323077,0.057666395,-0.007908475,-0.04538243,-0.122640446,-0.08753429,-0.05019159,0.011695846,0.00401476,-0.05919215,-0.09031473,-0.01568801,0.012818971,-0.06406962,0.03960907,0.018959308,-0.08418178,0.046997923,0.032149207,0.04571137,0.022715025,0.0073646237,0.04778874,-0.007575677,-0.026497042,0.09184795,-0.06703271,-0.05907839,0.03344936,0.0056486367,0.010445624,0.08724965,0.095083326,0.026131108,0.08118325,-0.040310998,0.017705167,-0.007954386,-0.057441335,-0.047140248,-0.07858567,0.03738315,0.038276415,-0.031501755,-0.018026747,0.06476137,-0.0010450374,0.020699652,-0.07407526,-0.009583053,-0.022053955,0.062063362,-0.030576047,0.010216191,-0.037813872,0.056595463,-0.06345589,0.025583953,-0.037883513,-0.06915719,0.047797646,-0.04335401,0.031854168,0.013147862,-0.0935916,0.01612805,-0.064499974,0.052573487,-3.384668e-33,0.055552345,-0.04630811,-0.0029893795,-0.0902704,-0.037108034,0.1174913,0.017838804,0.013257259,0.03849378,0.0007967623,0.054846603,-0.016053803,-0.010305258,-0.10367335,0.031797227,0.027486471,-0.0922844,0.042529088,0.0060305954,-0.017496414,0.052567396,0.058829296,0.08997657,0.036114898,0.100333154,-0.042931803,-0.007567526,0.040567826,0.08002066,0.05831791,-0.032826737,-0.07492601,0.041950766,0.0148266805,-0.029469546,0.03799605,-0.019992655,-0.03221213,0.044678204,0.02321175,-0.037387762,0.03096546,0.047035307,0.12643732,0.0045906575,0.07558686,-0.13960426,0.037122477,0.03328147,-0.0077106752,-0.03533504,-0.03868499,-0.093153864,-0.045331627,-0.043702677,0.013520902,0.008345406,0.036806602,-0.12200357,0.012945809,-0.029472573,-0.054489758,0.05800146,0.08451243,0.018448897,-0.00012247915,0.0037189457,-0.030591773,0.0075478386,-0.0020152188,0.114395365,-0.014218172,-0.0041460684,0.042097546,0.02925932,-0.09383132,-0.04150942,0.024789037,-0.007987307,-0.0044152793,0.027037399,0.015834998,-0.010309551,-0.058161613,0.052728202,-0.09732357,0.033876717,0.1121465,-0.05245213,0.007916309,0.012082432,0.023000794,-0.004397338,0.08071631,-0.0016142298,-3.7981984e-08,0.028513342,-0.09605795,0.11134442,-0.06805894,-0.01765574,0.011278394,0.06585553,-0.014889731,0.04608153,0.019615792,0.0465458,0.026995087,-0.0279166,-0.03557969,0.04161246,0.06304992,-0.019707734,0.033997633,-0.053213935,0.043141082,-0.005054146,-0.019017246,-0.11644215,0.080752805,0.021339284,-0.0077707646,0.035900827,0.073245294,0.03407739,-0.03464141,0.0071868594,0.044047926,0.040135115,0.0065168287,-0.1123589,-0.04224493,-0.00204425,0.04535171,-0.058937024,0.037789535,-0.034211915,-0.032204065,-0.030330746,-0.02394345,0.008851294,-0.0008116224,-0.0008824755,0.044856012,-0.0056028934,0.05168814,0.04654927,-0.020408379,-0.0238415,-0.03720157,-0.09130303,0.013633071,-0.03606423,-0.06537177,0.02274186,-0.051807445,0.08864154,0.012588139,0.20039473,-0.02886602 +1.17.99.9,"Contains a heme b cofactor. The enzyme catalyses the conversion of heme o to heme a by two successive hydroxylations of the methyl group at C-8, using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme a [2,4]. The electrons produced by the reaction are transferred to a heme b cofactor [6]. However, the electron acceptor that is used to restore the heme b cofactor to its oxidized state is still not known (both a thioredoxin-like protein and menaquinol have been proposed).",384,1.0,-0.08935984,0.015668536,-0.07420942,-9.9862635e-05,0.041627064,0.013805036,-0.03348128,0.05118262,-0.032751493,-0.0007652642,-0.01733901,-0.030332522,-0.09304209,0.009211544,-0.019095901,0.08624537,-0.06968556,0.037992038,-0.063717075,-0.027345711,0.0023808763,0.03579214,-0.05328847,-0.016649691,0.021457998,0.021812161,0.081006914,-0.0007960019,-0.019256229,-0.105247915,0.046330944,0.009241749,0.019469641,-0.053725023,0.03679743,0.06920453,0.0071673156,-0.14980993,-0.037027206,-0.030511927,0.054454762,0.0041315984,-0.053120784,-0.013637847,-0.03755889,0.03043008,0.096290514,0.016434854,-0.017232828,0.014939496,-0.013478648,-0.019039948,-0.0315571,0.046180304,-0.051953718,0.00803488,-0.013521246,0.010185169,0.029716343,-0.00961164,-0.03570371,0.033234518,-0.010116842,0.030124236,0.00066351297,-0.08210288,0.02429452,-0.027117634,-0.045037225,-0.0335191,-0.0044568307,-0.047109112,-0.06620732,-0.005379976,-0.049169227,0.029608628,-0.017721822,-0.04011027,0.07878565,-0.0016552968,0.013237194,0.024132805,0.06929137,0.17820786,0.008294013,0.040102128,-0.05939021,-0.041899838,-0.03004396,-0.0015229164,-0.0027558682,0.031905953,0.028024808,-0.029111784,0.000589377,0.04863211,0.11265805,0.1020788,0.034747392,-0.0124491695,-0.029944036,0.050007917,-0.108903445,-0.06715432,-0.010430186,-0.012194245,0.047416165,0.11855733,0.16321693,0.016487995,0.008290857,-0.006474193,0.064235024,-0.034583926,-0.041232586,0.08047022,-0.00011474983,-0.008735555,-0.04023429,-0.06043895,0.002690547,0.010579857,0.056190174,-0.051542137,-0.045254942,-0.009433406,-0.10011828,4.1054474e-33,0.033620745,0.018935826,0.008835733,-0.007952543,-0.04591658,-0.07127187,-0.12867738,0.018234452,-0.010325137,-0.028757555,-0.083116286,-0.053959306,-0.010317956,-0.010438515,-0.031820178,-0.1089863,-0.0010744333,-0.03306067,0.025029596,0.011736377,0.042614274,0.084257886,-0.017286621,-0.03501032,0.009454247,0.032283783,0.07079096,0.004151484,0.022927813,0.001972886,-0.025901841,-0.02220957,-0.059473388,-0.048740827,-0.010831153,-0.021835966,-0.033203967,0.04652352,-0.06532855,0.037183646,0.04659287,0.066096105,-0.072231255,-0.06740823,0.094635144,-0.09842702,-0.025816144,0.019248238,0.057384934,0.015275327,-0.0040868768,-0.008349663,0.10807155,0.010784286,-0.058769554,-0.03995194,0.0091589885,0.001871717,0.07128855,0.059723932,0.056523953,0.075730994,-0.029091045,0.034613933,-0.0058549303,-0.01708998,0.0013317971,-0.0126177315,0.009418423,-0.0027763096,-0.016446745,0.013419715,0.030369006,-0.042022735,0.009380797,-0.046205048,-0.052502282,0.019434385,0.070534594,-0.06982164,0.11204842,-0.040988654,0.0523991,0.0017543458,-0.017165963,0.0013120319,0.00503522,-0.038656402,-0.068142414,0.028267149,0.064114295,-0.16426781,0.029110448,-0.09208135,0.04264404,-4.3701063e-33,0.106773354,-0.028890725,-0.0029958861,-0.086274505,0.016575752,0.034901377,0.05598292,-0.0017289179,-0.01059685,-0.0068100053,0.08109978,0.035524,0.011665266,-0.026844457,0.032384507,-0.0026669386,-0.01864887,0.018201226,0.0013429445,-0.05940788,0.030766876,0.015004635,0.0062706573,0.010632427,0.07963752,0.0127596,-0.024938408,0.0053783287,0.09109368,0.062028293,-0.0032365015,-0.005233126,-0.014866326,0.020993005,0.006436776,0.055183455,-0.036596607,0.05180956,0.021294909,-0.0077081155,-0.011301918,-0.03587406,0.09295643,0.060460094,0.092561506,0.10035008,-0.16562799,-0.032645624,-0.016930168,0.02224963,0.026401483,0.038864188,-0.10641666,0.02369773,0.024039079,-0.0027507048,0.041630294,-0.030028475,-0.07803682,-0.03973655,-0.051166076,-0.04128764,0.05178888,0.011209696,0.0070370836,0.08129592,-0.08439522,0.085744016,0.019832106,-0.060710452,0.061869122,0.023748271,0.03274267,-0.0077891713,0.06287413,-0.055321977,0.038407624,0.02344788,-0.00068055,-0.008477005,-0.05947032,0.024399329,0.008610403,-0.07128703,0.045356784,-0.0699953,0.010274587,0.041849777,-0.034071922,0.05410859,-0.034834865,-0.039699443,-0.015313189,0.08780429,0.05027754,-4.514836e-08,-0.08139607,-0.10561796,0.0438015,0.0064622336,0.0182549,0.039730072,-0.015234034,0.0007391461,0.087725766,-0.039779935,-0.032043625,0.060063098,0.027149022,-0.032069467,0.035963405,0.017795892,-0.0048488323,-0.03602005,0.0012578603,-0.053151477,-0.021542508,-0.0007778255,-0.044166744,0.08160593,-0.0076362984,-0.07742684,-0.078213565,-0.059455216,0.015125089,-0.004713129,-0.017071573,0.11354255,0.0042359605,-0.006339894,0.011137986,-0.059792034,-0.01189166,0.0030580806,-0.038430594,0.0010234655,0.0098417755,-0.03752852,-0.08213802,0.007964866,0.07354906,0.0004560688,0.00674857,0.029269176,-0.05313396,0.0066670272,0.08078305,-0.010110187,0.01611811,-0.029708602,-0.099585816,0.0037961532,-0.049903177,-0.02541112,-0.0007920552,-0.09458629,0.09720908,0.004554545,0.17365636,0.012551412 +1.17.99.10,"The enzyme, characterized from the bacterium Sterolibacterium denitrificans, participates in the anaerobic degradation of cholesterol. The enzyme can accept several substrates including vitamin D3. The enzyme contains a bis(guanylyl molybdopterin) cofactor, five [Fe-S] clusters, and one heme b. cf. EC 1.14.99.38, cholesterol 25-monooxygenase, an oxygen-requiring eukaryotic enzyme that catalyses a similar transformation.",384,0.99999994,-0.08110001,-0.07481658,-0.1504613,-0.01574337,0.023208342,-0.025311124,-0.074943215,-0.004759724,-0.0015383807,-0.043217756,-0.0035934316,-0.051375527,-0.057211377,-0.017473588,-0.00095251633,0.0027293216,-0.041951455,0.02428597,0.024812082,-0.03156747,0.015048796,0.027024655,-0.03451999,0.016462367,0.02402404,0.036679566,0.07364765,-0.06507367,-0.09058058,-0.049781494,0.016972302,-0.038697325,0.11539964,-0.07276815,0.047573995,0.09504722,0.006810282,-0.007531519,0.046006855,0.016877398,0.030619506,0.049203333,0.00074335694,-0.020571264,0.049270745,-0.04515168,-0.04086874,0.04192055,0.03933354,-0.008545105,-0.03276675,-0.060286928,-0.026494363,0.016892195,0.026385415,0.0063332743,0.0044032503,-0.06200478,0.017015828,0.016505063,0.07540221,-0.018255636,0.092364915,-0.03825472,-0.014479936,-0.0713507,0.053580664,-0.0818143,0.04118986,-0.03209856,-0.096434,-0.051809948,-0.057906333,0.004347915,-0.041165974,0.05527766,-0.02686431,-0.10564298,0.11077852,-0.077107325,0.02463766,-0.010876579,0.022748245,0.1260065,0.07550825,0.0019495114,0.033397518,-0.04181666,-0.018428013,-0.001023199,-0.0072888695,0.017569974,0.010405869,0.0089398865,-0.09788366,-0.03681811,0.02991384,0.053265627,-0.014063948,-0.032391027,0.008778648,0.09902517,0.005433994,-0.05581582,-0.066299856,-0.048248317,0.065235876,0.10445788,0.038068958,0.042565394,0.0041169617,0.0003473645,0.052802246,-0.010068433,0.015769511,0.09841663,0.07195534,-0.05753087,-0.07106974,0.041728783,0.053900514,0.012563123,0.016656013,-0.022458876,-0.01825774,0.03324604,0.006645727,2.4002592e-33,0.07130938,-0.03334835,0.014474014,0.055852782,-0.03492897,-0.019811714,-0.10631009,-0.00030754713,0.039954435,-0.06420065,-0.013897106,-0.054248024,0.06749693,0.0926344,-0.039520536,-0.0086400155,-0.0008549019,0.008509728,0.06581377,0.021825878,0.00545291,0.09353601,-0.07632542,-0.020314097,0.02660391,0.007930939,-0.022562478,0.03879926,0.032675166,0.010188618,-0.017787825,-0.12357468,-0.1514299,-0.005013023,0.0591975,0.015954172,-0.017779956,-0.00047868508,-0.097646646,0.11350947,-0.00227532,0.0022950934,-0.02982992,-0.034057353,0.045998055,0.026724119,0.0052902424,0.07076902,0.054377884,0.04938394,-0.0055731637,0.028277352,0.070606805,0.0029837752,-0.030211827,0.023104658,0.028681148,0.02254601,0.03313172,0.036307342,0.036520384,0.049719784,-0.07975187,0.077003,0.025509765,0.011327535,-0.05358639,-0.020501943,0.011821448,0.078792065,-0.05009012,0.017414985,0.014921582,0.02836757,-0.051490694,-0.006210394,-0.051532708,0.0027650483,-0.001867737,-0.07204693,-0.04179011,-0.047882486,-0.004890957,-0.1167588,-0.035401497,0.049558617,-0.06648325,-0.04776301,-0.009564958,-0.03610381,-0.017019434,-0.027560135,-0.06526315,0.028512767,-0.03201637,-3.122115e-33,0.051625628,-0.09318444,0.057837445,-0.090194404,-0.08022053,0.116105646,-0.0028609175,0.0032217475,0.072188236,-0.050507236,0.02348571,-0.005851808,0.042019296,-0.041345812,0.028294733,0.07637875,-0.04675769,3.884912e-05,-0.035335727,-0.035214886,0.0066383732,0.08480598,0.028224025,0.091216266,0.036267385,0.090521455,-0.03278648,-0.001043714,0.09883386,0.037407942,0.024243785,-0.03370904,-0.047152717,-0.019641839,-0.10564446,0.062189765,-0.04260145,-0.0066634417,-0.030152088,0.0075192265,-0.063299954,0.007084972,0.02446173,0.076836854,0.052852366,0.012785116,-0.046856783,0.035538442,0.03835524,0.0147380335,0.020671567,-0.024781024,-0.00084223214,0.050516263,0.028098958,0.066182196,0.03502987,0.051976673,-0.0156197045,-0.025372697,-0.05685484,-0.026945205,0.06619552,-0.011477434,0.032036506,0.08004681,0.018779205,0.042986047,0.040899877,-0.035482164,0.04030343,0.09396497,-0.019329308,0.021918828,-0.022239737,-0.006663269,-0.055255696,0.016598806,-0.0064952066,0.0035897754,-0.0064956136,-0.023800043,0.008447896,-0.042440422,-0.047838982,-0.08500786,-0.03999942,0.04076642,0.032185525,0.022528896,-0.053042375,-0.069213144,-0.11522443,0.026270406,0.0053145913,-4.103405e-08,0.06492207,-0.030218408,-0.0055502476,-0.047116786,-0.043649085,0.030095002,-0.008231008,-0.021156535,0.06595865,0.0041961814,0.03967994,0.13162142,-0.011479894,-0.009090469,0.0075981747,0.05097559,-0.040061504,-0.0032193018,-0.009821329,-0.008729751,-0.024859654,-0.05338188,-0.088001415,0.07324884,-0.011938627,-0.04468318,0.007981385,0.02776079,0.010989255,-0.018204367,-0.010043463,0.0077806297,0.015792498,0.011537287,-0.0027117273,0.0083468435,-0.01233722,-0.053390555,-0.038403835,0.13622999,0.0124388505,-0.026502958,-0.10979848,-0.013977058,-0.012263221,-0.010541194,-0.0518255,0.06089343,-0.05728062,0.009050667,-0.04031615,-0.044010073,-0.0040106005,0.0588931,-0.13655141,0.047852725,-0.039438155,-0.069795616,-0.032058675,0.02767076,0.03233145,-0.005536327,0.22442028,0.008054145 +1.17.99.11,"A molybdenum enzyme. The enzyme, characterized from the bacterium Steroidobacter denitrificans, is involved in the anaetrobic degradation of steroids. It is specific to 3-oxo-Delta1-steroids such as androsta-1-ene-3,17-dione and Delta1-dihydrotestosterone and does not act on 3-oxo-Delta4-steroids.",384,1.0,-0.048556976,-0.042702843,-0.13083495,-0.035327207,0.00022266258,-0.08542917,-0.052899312,-0.0120628495,-0.0075292382,-0.077664055,0.019283902,0.01875842,-0.028434444,0.017145209,-0.083647296,0.03680278,-0.028944584,0.019205939,0.024046365,0.009057136,0.063397,0.0426055,-0.030263726,-0.027027942,0.02554557,0.00013224677,-0.03441813,0.02013056,-0.02966911,-0.06922594,0.009929505,0.02544216,0.04411756,-0.02877715,0.08296297,0.086334124,-0.032429777,-0.04936664,0.059396032,0.07646415,0.019196182,0.04083239,0.013370246,-0.03781229,-0.03682597,-0.067806266,-0.039917335,-0.02343313,-0.0022827243,-0.012761554,0.007421784,-0.11847963,-0.041907385,0.07212195,0.039806556,-0.02512107,-0.07000404,0.027806647,-0.040573657,0.008358307,0.058099236,0.08313307,0.06154183,0.089391224,0.011047874,-0.042764477,0.009005319,-0.07623384,-0.040361308,0.0011367578,-0.05758573,-0.04953164,-0.009739116,0.07372836,-0.052739456,0.043362994,0.005481812,0.0025341,0.089614995,-0.068889625,0.014326523,-0.0057649156,-0.015451363,0.02543107,0.013022144,-0.03313546,-0.0062373937,-0.051003277,0.059685186,-0.014910769,0.00074059045,0.025338698,0.01865483,-0.009187947,-0.074066214,-0.0023547593,0.017004201,0.025140572,-0.06924779,0.03880338,-0.026000714,0.07161934,-0.013557919,-0.029827455,-0.07679552,-0.028450986,-0.0033774218,0.04839654,-0.0034254072,0.056179445,-0.045384653,0.03733686,0.08850509,-0.0019772165,0.03517614,0.010162176,0.06888566,0.051298387,-0.03479136,-0.08141429,-0.013108189,-0.021765582,-0.013802127,-0.016302183,-0.027648626,0.077491604,-0.042707235,2.7481045e-33,0.1625811,-0.035369042,0.012570496,0.015768114,0.005374144,-0.023591591,-0.005455268,0.0058822646,-0.009129189,-0.077307336,-0.016179062,-0.04435655,0.018841555,0.06607037,0.06816883,0.019227337,0.005408411,-0.0039599626,0.06866881,0.010088929,-0.007951886,0.09429514,-0.043869182,0.012733944,0.026272397,0.028017638,0.00022734974,-0.020992585,-0.005335454,0.024775276,0.005867126,-0.06995124,-0.08800375,-0.03706805,0.038558114,-0.02068078,-0.009946683,-0.023764422,-0.0303659,-5.6970046e-05,-0.061657798,-0.0043001487,-0.047485862,-0.045800366,0.043782067,0.03093215,-0.030313531,0.12650403,0.07806127,-0.020872423,-0.010458267,-0.019405618,0.058017697,-0.040773444,-0.061378334,0.08898084,0.029703908,0.016628413,-0.023226684,0.076376006,-0.0055111833,0.056138985,0.00916896,0.08300893,-0.033250198,-0.0070013064,-0.108612254,-0.08438994,0.006929205,0.057594273,-0.095507644,0.028290594,-0.018622622,0.03979138,0.0049013137,-0.06924402,0.0867944,-0.093653664,-0.021932311,-0.06071896,-0.025532918,-0.040317077,0.06277646,-0.09114822,0.005527979,-0.005181098,-0.07138537,-0.06106854,-0.0205128,0.04216572,0.04966276,0.030767716,-0.10734766,-0.005013488,-0.008153797,-4.0402564e-33,0.07865546,-0.088755734,0.08613081,-0.062982455,-0.054450203,0.05390442,-0.018569587,0.06388077,0.005374328,-0.027973054,-0.017035993,-0.006940007,-0.025942553,-0.105084874,0.04024913,-0.017002026,-0.029811671,0.004602194,-0.044723567,-0.029629976,0.038502965,0.1342583,0.03176068,-0.052597728,-0.014510663,0.06589384,-0.06016409,0.08296755,-0.008651672,0.0025042216,0.013059388,0.0053013344,-0.024557583,-0.0641574,-0.088760845,0.06976035,-0.023389297,-0.02238498,-0.003298714,-0.009152138,-0.044598866,0.02745368,0.018280884,0.060448468,0.05930264,0.024067475,-0.08233555,0.030310245,0.060457714,0.0021484522,-0.01093943,-0.051827315,0.050416797,0.060742393,0.020469798,0.011887937,-0.029951712,-0.017887333,-0.03506669,0.014016154,0.020776508,-0.028738193,0.021853616,0.051269718,0.025330761,0.09100598,0.050445072,-0.0027872587,0.040764112,-0.0039721075,0.042121347,0.006462926,-0.053413242,0.067795604,0.0063080657,-0.027257077,-0.13598323,-0.0034170796,-0.034118183,0.01308069,-0.09100105,0.06675214,0.013058541,-0.042888265,0.06586261,-0.050169896,-0.014428456,0.12664424,0.06276566,0.032994285,-0.03735978,-0.016970329,-0.0837164,0.0038354434,0.026778419,-4.150063e-08,0.015645117,-0.06206108,0.02951675,-0.07435142,-0.009760167,0.04370141,0.028534662,-0.0122671025,0.13218454,-0.07101272,0.029098423,0.120256,-0.0008898483,-0.010288208,0.016207995,0.080089286,-0.049116578,-0.012062089,-0.036500435,0.0054427953,-0.013601787,-0.05236769,-0.09890987,0.12304454,0.04142336,-0.023454407,-0.020707795,0.13705848,-0.057579003,0.05591478,0.025892535,0.014560505,0.05547,-0.026759798,-0.061194442,0.062518276,-0.010442992,-0.04582031,-0.022235727,0.02062881,-0.035021976,-0.019491918,-0.005612994,0.039994624,0.046026394,-0.0074962815,-0.037824836,0.072500736,0.002337139,-0.037826635,-0.014687658,-0.020611063,-0.051326573,-0.015807793,-0.14644438,-0.023143956,-0.01394182,-0.04207188,-0.057771824,-0.014079429,0.01866713,-0.020738525,0.20742135,0.014904622 +2.1.1.373,"The enzyme, characterized from the marine bacterium Labrenzia aggregata, participates in the biosynthesis of dimethylsulfoniopropanoate (DMSP). A eukaryotic enzyme that shares little sequence similarity with the bacterial enzyme was identified in many marine phytoplankton species.",384,1.0,-0.10711254,0.015487329,-0.033103373,-0.047403187,-0.040447004,-0.018686498,-0.073405676,0.05955896,0.027570907,0.00233369,0.0062292567,-0.10812645,-0.10574462,0.035322893,-0.0439703,0.09529603,-0.046782896,0.024799533,0.01577555,0.009204541,0.066734225,0.0795987,-0.071489915,-0.0133850835,0.032973975,0.05229385,0.061741527,0.077556424,-0.04276545,0.01272845,-0.051808193,0.00019753221,0.07157748,-0.07093098,0.11304639,0.057177965,0.014447168,-0.075954475,0.036106337,-0.029646542,0.06373413,0.039888985,0.009763579,0.044782165,-0.05151685,0.020767298,-0.00062539964,0.06043017,-0.045570772,-0.07683591,-0.081889845,-0.021626009,-0.0685095,0.005453039,0.011929532,-0.031517625,0.005737251,-0.012034938,-0.0015495147,-0.07494808,0.0004924577,0.001584797,0.004981697,-0.004232605,0.008271928,-0.03832802,0.05755926,-0.058753904,0.033606753,-0.037506033,-0.08318234,-0.06200027,-0.04699176,0.06467779,-0.053839505,-0.0018775692,0.030051155,-0.022080008,0.082656585,-0.014720988,0.03329806,0.016655667,0.013579842,0.06783062,3.6763868e-05,-0.051007424,0.02666645,-0.0052174763,0.07751787,-0.0010725765,-0.0093687195,-0.07435519,-0.045486044,-0.096000694,-0.11805724,0.037220012,-0.04630663,0.08379839,0.02795564,-0.008618438,0.04104272,0.00024358537,-0.020195974,-0.12073314,-0.02410574,-0.019680288,0.061828386,0.121585384,0.054919697,-0.008909536,-0.00622042,0.036781967,0.010068154,0.07170007,-0.010453536,0.051902898,0.005465275,-0.12621942,-0.03266571,-0.00055428257,-0.031005904,-0.09149699,0.07639227,0.055692967,0.016457368,0.05691285,-0.07988665,2.8215402e-33,0.09156176,-0.0058090226,0.0010188313,-0.09485736,0.0748461,-0.061138045,-0.052435108,-0.019059183,-0.05447336,-0.03655889,-0.15194638,-0.029563028,0.0024539183,0.02806059,-0.054014757,0.028698092,0.011845072,0.03826296,0.047211453,-0.0067899562,0.029762516,0.048891783,0.012705455,-0.036580104,0.056361165,0.052752238,-0.04082037,0.010840702,0.06054824,0.00846212,0.049922537,-0.14640202,-0.092716455,0.014198674,0.0891953,0.032851696,-0.058285333,-0.06362952,0.0069330274,0.02172436,-0.033080604,0.031768177,0.024097575,0.011870286,0.032056436,0.025614815,-0.04372143,0.058592714,0.042649668,0.009897929,0.04184588,-0.030495426,0.109853946,-0.0058565834,-0.041883234,0.08764006,0.02917807,-0.017837035,0.011249989,0.027121453,-0.048923023,0.07658926,-0.03352328,0.049880307,0.09546071,0.024803195,0.046921816,0.014674042,0.047319464,0.008617257,-0.05025448,-0.073332414,0.031194972,0.030527575,-0.024973108,-0.07986835,0.05260003,-0.054650772,-0.05754342,0.03503519,0.009947535,-0.035233345,0.00964151,-0.10976023,-0.0674844,0.02739894,-0.02785984,-0.01996561,0.024568146,0.02295776,0.036961813,-0.054802023,-0.055301953,0.01789873,-0.024260443,-4.3383974e-33,0.021260343,-0.054021377,0.039841462,-0.03201326,-0.03962448,0.022079894,-0.02765699,0.032491256,0.0030809888,-0.03229462,0.04987324,-0.036791764,0.03446525,-0.00065459195,-0.0064816377,0.060929336,0.00062500336,0.06228062,-0.018647412,-0.024116242,0.0031182307,0.05240441,-0.033546485,0.09078915,-0.0067847315,-0.009346785,0.0031463378,0.05622415,0.029955328,0.010082269,0.018261656,0.06169587,-0.029316036,-0.09296442,-0.03507468,0.019594437,-0.015664304,0.032965276,0.027255582,0.0814594,0.014855339,0.022215482,-0.03514832,0.04967301,-0.021780502,0.033547577,-0.028917314,0.035424624,-0.021160712,-0.053928528,-0.012145237,0.027549004,0.051789586,0.025549084,0.032887474,0.061038144,0.025323791,0.084644124,-0.02283865,-0.0338385,-0.005239914,-0.13352199,0.04911897,-0.0023581742,0.06701816,0.1347166,-0.027114308,0.015342829,-0.029555015,-0.0036965185,0.038168408,0.02839308,-0.07456345,0.0079154745,-0.06984521,-0.045173913,-0.12515229,-0.010196027,-0.014762086,0.03687087,0.06915923,-0.01837729,0.023136573,-0.009353293,-0.09370536,-0.09258665,0.10282554,0.1145934,-0.08360874,0.016621487,0.017764615,-0.0074266726,-0.0754225,0.05256466,0.02039046,-3.430085e-08,0.023103587,-0.023249535,0.03909523,0.0058870227,-0.059722703,0.02129769,-0.0042935736,0.04415511,0.049914338,0.03575437,0.017133944,0.062638424,-0.047055986,-0.039409466,0.050462045,-0.020592697,0.010025523,-0.0146827735,-0.027721727,0.056660265,0.011692671,-0.0086047035,-0.07812973,0.008852057,0.02704258,-0.034177214,0.018569522,0.04544697,0.006962056,-0.000332284,-0.05769523,0.031482246,-0.07289625,-0.01276959,-0.06645402,0.009790907,-0.06614968,-0.12925847,0.0022978769,-0.00074505847,-0.0017781949,0.018178038,-0.059950676,0.03456586,-0.01937944,0.06829665,0.054205853,0.021541383,-0.037355874,-0.03229038,0.01911583,-0.008668501,0.015932687,-0.093457796,-0.09979457,0.06825917,-0.0065423357,-0.033559065,-0.11090304,0.03998766,0.029284006,-0.008791104,0.111945145,-0.053487297 +2.1.1.374,"The enzyme, found in mycobacteria, is a member of a family of heterocyclic toxin methyltransferases. It is involved in defense against several antimicrobial natural compounds and drugs. 4-Hydroxyquinolin-2(1H)-one, 2-heptylquinolin-4(1H)-one, 2-heptyl-3-hydroxyquinolin-4(1H)-one (the ""Pseudomonas quinolone signal"", PQS) and the flavonol quercetin are also O-methylated, albeit with lower activity [2]. The enzyme also N-methylates the bactericidal compound 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile [1]. ",384,1.0,-0.064991936,-0.027734354,-0.10638357,-0.007855023,0.017711552,-0.010898992,0.0377349,0.109443486,0.046089794,-0.06436029,-0.003471095,0.0021127812,0.026160948,0.082407795,-0.068892606,0.112619944,-0.02730866,-0.0074433223,0.015528223,0.026594413,-0.029803902,0.107722215,0.033994116,0.0052057765,0.007470987,0.03901709,0.011438831,0.06861878,-0.032721344,-0.044944882,0.019564347,-0.020979695,0.023359632,-0.036872614,0.0719097,0.03399966,0.00037936747,-0.040117517,0.084095865,0.023158174,0.06578568,0.0022157622,-0.0023159657,-0.0060256603,0.06766393,0.010540901,-0.029497063,0.042948715,0.052783784,0.04264301,-0.09734421,-0.037920266,-0.021654295,0.115580834,0.03487926,-0.0051311576,-0.011969847,-0.014306912,-0.032316986,0.06332997,0.04679178,0.015545343,0.021953339,0.03407327,-0.059392635,0.0051923897,-0.011631308,-0.029616237,0.06241142,-0.056155916,-0.08721271,-0.05235749,-0.015504452,0.035351112,0.0023322066,0.036581375,0.014974514,-0.0005666828,0.013836277,-0.056943115,-0.02931926,-0.06324708,-0.04296774,0.038940582,0.017394707,-0.048194513,0.054172944,-0.001512251,0.1025752,0.107278265,0.028196516,0.013838429,0.008169327,-0.09106024,-0.028897827,0.010892001,0.061768156,0.023439506,0.02468129,0.021666644,0.043522622,-0.06751091,-0.033435803,-0.049321115,-0.04584473,0.024075836,0.045047157,0.02004547,0.08076749,-0.029411288,-0.07504997,-0.011534793,-0.012925973,-0.038302686,-0.014685185,0.057884425,0.13462092,0.01685845,-0.087839015,-0.010594468,-0.019461242,-0.035009056,0.07535617,-0.0635721,-0.06840982,-0.0035175441,-0.10686031,2.1412574e-33,0.04717545,0.05139275,0.0009188728,-0.029666014,0.06324234,-0.028139716,-0.062275175,0.04218665,-0.07237632,-0.08541289,-0.0620995,-0.08386847,-0.005875841,0.07169605,-0.027968042,0.08156286,-0.039778564,-0.06847457,0.060498226,-0.007924081,0.043856442,0.012029513,-0.039027378,0.052684825,-0.00624503,0.044537317,0.03166503,0.053835597,-0.017287346,-0.015970033,-0.015348666,-0.11150585,-0.07003557,-0.091310926,0.04096018,0.029356344,-0.08173334,-0.02900554,0.013229013,0.059935655,-0.017442308,0.0014416447,0.011819454,0.012588025,0.022761857,-0.0146099515,-0.06885599,0.07635925,0.0072492776,0.048367918,0.017520636,-0.079832986,0.052270994,-0.012586166,-0.06717715,-0.034432862,-0.019742267,0.04671404,0.025383843,-0.02454375,0.019350747,0.0066672633,-0.029983977,0.06070871,-0.04562579,-0.05828291,-0.02058403,0.03923953,0.034749463,0.020432716,-0.016335795,-0.005514464,0.026398554,-0.026025655,0.103714116,-0.06904028,-0.10454913,-0.041338358,0.007863577,0.0036187097,-0.006232407,-0.014058592,0.023345463,0.01564677,-0.10034912,0.04656369,0.0022575404,-0.022135293,-0.035600215,-0.01059829,0.015085374,-0.06172243,-0.035660658,-0.008121285,-0.028284127,-3.11229e-33,0.047949202,-0.092481114,0.09488174,-0.043892425,-0.01888178,-0.018565783,0.010663034,0.03325484,0.050296515,-0.021234661,0.08957867,-0.02122083,0.06005218,0.018337388,0.010668019,-0.0019802107,-0.023062533,0.08526576,0.029964011,-0.0026646554,0.01585189,0.009222133,-0.033924427,0.034632117,0.0346508,0.03797654,-0.011645418,0.002109871,0.06066141,0.13919614,-0.03844791,0.05020582,-0.004525107,-0.090638354,0.027973251,0.04354452,-0.044682242,-0.06604962,-0.03826332,-0.020350192,0.05406176,0.008300589,-0.0091617545,0.0043706936,-0.071041316,0.09160558,-0.10852411,0.058589295,-0.0042612227,0.019716093,0.019049857,0.04894883,-0.012364631,0.06831563,0.06375138,0.028005086,0.020747539,-0.013774325,0.02122842,-0.03585841,-0.0671742,-0.09660743,-0.010359088,-0.022107089,0.07144814,0.095729955,0.038912576,0.074477576,0.066213295,-0.11671202,0.053350978,-0.0014955736,-0.003098103,0.044234574,-0.09051491,-0.0031126465,-0.010203144,0.0057569076,-0.008533856,0.014066746,0.05736662,-0.09108593,1.4215817e-05,-0.09953479,-0.06317337,-0.05263443,0.00437207,0.13367274,-0.06273356,0.05698498,0.029217562,0.08075278,-0.06904968,-0.0044694804,0.011894522,-5.1237784e-08,0.0060816393,-0.11116944,0.0638974,-0.012193514,0.02177946,0.049387716,-0.04431054,-0.0024505365,0.034595322,0.013927833,0.085681625,0.056758218,0.025287807,-0.018387701,0.0038510947,0.01064248,-0.060678676,-0.018267658,-0.007356156,-0.043150406,-0.070135735,0.008073228,-0.08866475,-0.027184078,0.046926957,-0.07264011,0.008013106,0.0801624,0.044506226,-0.08444386,-0.0085254405,0.045162115,0.0008491078,-0.06320059,-0.16518074,0.009517483,-0.048043583,-0.06799391,-0.008990123,0.020498162,-0.0036443193,-0.016399395,-0.08254645,0.012221274,0.016784748,-0.03042882,0.020169334,0.037229955,-0.032178298,-0.051589515,0.03814515,0.013190747,0.046303224,-0.02354455,-0.089276865,0.063613474,0.0056768414,-0.009535441,-0.07717044,-0.082529,0.00877347,-0.042192716,0.14288491,-0.0036438734 +2.2.1.13,"The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose.",384,1.0,-0.010717851,-0.049822982,-0.011911123,-0.03040062,-0.017747216,0.00010416002,-0.07669161,0.02012189,0.035755288,0.07740424,-0.0058297324,-0.031696104,-0.042020656,0.082912594,-0.02210022,0.043449588,-0.084883094,0.031416588,-0.032128934,-0.009902853,0.10729442,0.052869167,-0.012106387,-0.06035086,0.03928096,-0.03481488,0.097833104,-0.022893658,-0.05446615,-0.046231274,-0.025056941,-0.046470374,0.03025056,-0.004232167,0.07550718,0.045013174,0.026931433,-0.037550174,0.06979521,0.0002979943,0.0018248165,-0.01211736,0.010437837,-0.014509574,-0.069328904,0.014629447,-0.07254768,0.020688102,0.012070894,-0.020146746,-0.051223747,-0.06265584,-0.038105544,0.007907252,0.046322744,-0.013994073,0.0018091127,0.01128746,-0.05245691,-0.062032823,0.068182275,0.01348,0.06940905,0.05410239,0.02082399,-0.040322073,0.009222289,-0.026207337,0.015828568,-0.081414975,-0.066444404,-0.10101094,-0.042791594,0.030849587,0.016673585,-0.031250432,0.044307943,-0.04927883,0.014138358,-0.094823495,0.047390208,0.055806044,0.024258235,0.10644971,-0.014648772,0.05180601,0.034623142,-0.037972912,0.042213142,0.013019836,-0.013808782,-0.06993193,-0.016979255,-0.086577676,-0.065138444,-0.018036421,0.0132194385,0.015465527,0.027334405,-0.0383427,-0.051050585,0.08654528,-0.02624758,-0.060548257,-0.05653179,-0.0024408116,-0.021349544,0.0729144,0.022864882,-0.03323822,0.03825701,0.021634515,0.069731735,0.078542136,-0.030713027,0.044235587,0.023645664,-0.050945632,-0.019512856,0.0149498535,0.004109745,-0.04993793,0.057325944,0.07167553,-0.044917382,0.03938547,-0.05100519,-3.9938695e-33,0.07701653,-0.023794277,-0.030638412,-0.011090716,0.054700103,-0.06879065,-0.048186816,0.012923736,-0.11778397,0.018220795,-0.15511115,-0.1007017,0.036854904,0.05468623,-0.0045858747,0.022027943,-0.014177172,-0.0036069485,0.020038193,0.019473074,0.020169104,0.053896114,-0.009435582,-0.023028785,0.02476515,0.06042219,0.012546169,0.09858029,0.01398474,-0.027254311,-0.006783864,-0.1024362,-0.037233513,0.02785199,0.026910445,-0.019657854,-0.0072459285,0.020525083,-0.018132523,0.024871124,0.024905136,0.04629143,-0.008859157,-0.023136783,0.0394961,-0.0012132374,-0.0339609,0.07268619,0.010438631,0.08632905,0.092489235,-0.020120462,0.12285258,-0.038176153,-0.05616376,0.0071428623,-0.05646787,-0.029924996,0.0164776,0.03078253,-0.00479683,0.037105337,-0.06625272,0.08103661,0.03915977,0.014263465,-0.014566244,-0.01851812,0.024279056,0.090695165,-0.1187731,-0.010497617,0.047585413,-0.04230578,0.040251736,-0.076674886,-0.039990775,-0.024372483,0.042019125,-0.02130802,0.0077507054,-0.03755073,-0.027281096,-0.015982693,-0.072845206,0.009274025,-0.059099857,-0.09926928,-0.09184678,0.013841298,0.024215762,-0.04780377,-0.119405456,0.048047576,0.045484066,1.4279508e-34,0.0778154,-0.07032939,0.030871175,-0.077386804,-0.07655724,0.095090166,0.03670491,0.013066646,0.056751624,-0.0006645797,0.05303063,0.013489484,-0.017746104,0.0016793001,-0.003573258,0.042660024,-0.06777031,0.003554347,-0.044262774,0.020602323,-0.04851769,0.060449548,-0.04531839,-0.060517613,0.06152449,0.035554234,-0.018344866,0.12168652,-0.02840862,-0.030420186,0.108481854,-0.0045988,0.013682968,-0.048063364,-0.069774665,0.08812652,-0.03438365,-0.0049199252,-0.023329223,-0.00044240407,-0.05136399,0.003480292,-0.025555406,0.054521732,0.023885954,0.048342187,-0.085009284,0.03938795,-0.03643135,-0.028672645,0.004124278,-0.021775996,0.09065494,0.008005356,-0.008785739,0.0957443,0.03348529,0.05117546,-0.06483976,-0.003127295,-0.004184873,-0.08322043,0.11665395,0.07666103,0.022315245,0.0140080005,-0.018467838,0.008842762,-0.003223858,-0.010541085,0.022375239,0.0027057254,-0.042516734,0.002966779,-0.05382427,-0.09023432,-0.10948875,-0.035995107,0.046536103,0.06263136,-0.07107655,0.008004547,-0.008434132,-0.011111123,-0.043672547,-0.09514481,0.008956947,0.106147505,0.022168143,0.104298085,-0.035483494,-0.0016768256,-0.03466647,-0.033735033,0.067319535,-2.5831124e-08,0.08542653,-0.01929264,-0.01359266,-0.021792503,0.038532306,0.011132611,-0.058415875,0.05714077,0.02206284,-0.0017790925,-0.010178985,0.080340855,-0.048065282,-0.001675583,0.070747524,0.015285095,-0.010330647,-0.01811317,-0.041365676,0.045288663,-0.073043406,-0.023053698,-0.12849712,-0.010645281,0.063466996,-0.06115019,0.05639673,0.054209683,-0.040427893,0.0164932,-0.026698494,0.021653099,0.003605495,-0.085222244,-0.08002988,0.035508953,-0.044249337,-0.06906885,0.042407002,0.04021889,0.078987576,-0.002468166,-0.034184042,0.021645082,0.0027152158,0.055025183,-0.015074819,0.022938306,-8.507582e-06,0.026177434,0.0013389833,-0.007163909,-0.049714074,-0.047170505,-0.13254347,0.049410265,-0.032775667,-0.06215822,-0.013120193,-0.031864483,0.060498208,0.041190848,0.18664815,-0.057582177 +2.3.2.36,"This relatively rare subpopulation of RING-type E3 ubiquitin transferases (cf. EC 2.3.2.27), found in mammals and herpes viruses, can transfer ubiquitin to a cysteine residue in target proteins. Additional ubiquitin molecules are polymerized on top of the initial ubiquitin molecule by formation of an isopeptide linkage with lysine48 in the pre-attached ubiquitin [2].",384,0.99999994,-0.053346276,-0.05886963,-0.0626127,0.02583646,0.091688626,0.040969796,0.049323477,0.03755706,0.042189606,-0.01453535,0.0029795386,-0.010860539,0.058316756,0.022034867,-0.053007897,-0.025443148,-0.04961303,0.021032907,-0.005849827,-0.068144806,0.040724,0.0692502,-0.0025166944,-0.013085617,-0.019538103,-0.018226037,-0.002368026,0.030484047,0.018719291,-0.0892579,-0.03600437,-0.0963481,-0.021330187,-0.052013632,-0.010561559,0.07327858,-0.074055955,-0.03725084,-0.050980754,-0.03147882,0.1149889,-0.013841876,0.06217995,0.042711616,-0.0057846387,0.024541235,-0.086443216,0.02047998,0.050706584,-0.005050427,0.038320288,0.0030988944,0.032792106,0.09584621,-0.026017046,0.0002621733,-0.041421384,-0.010214602,0.025461966,0.009518922,0.023531917,0.09198071,0.07586962,-0.045451704,0.042982582,-0.034528736,0.041562848,0.0012807337,0.015033565,-0.00466596,-0.024380896,0.0042149974,-0.11052537,0.08914968,0.03233431,0.10449353,-0.043858316,0.058771703,-0.059628792,0.017880132,-0.012103027,-0.1051845,0.1201502,0.02999653,-0.016647229,0.007840249,-0.0894886,-0.036428567,0.0134008145,0.01818838,-9.6534975e-05,-0.013370652,-0.039629202,0.03356092,-0.05232625,-0.021493124,0.056337982,0.07112284,-0.0103977015,0.0072421604,-0.00056141784,-0.0018435149,-0.025950126,-0.03459567,0.0018488878,-0.004737226,0.043986585,0.017556928,0.03852417,-0.07294818,-0.0503252,-0.0055061597,0.0019865094,-0.06695069,0.056691624,0.034845307,-0.09299216,-0.056839943,-0.018233977,-0.01960642,-0.008725215,0.072234966,0.035459522,0.06927238,-0.04365173,-0.04885082,-0.09634469,4.2942767e-33,0.052537587,0.029315295,0.03987436,0.077854455,-0.10560793,0.042912807,-0.042158626,0.006717306,-0.021721613,-0.10616976,-0.02404713,0.0069886902,0.08288104,0.035835512,-0.030200943,-0.064103335,0.03568958,-0.059917163,0.06959409,-0.015009251,0.067297556,-0.005626852,-0.035819232,0.02475835,0.020235302,0.026326401,-0.020630317,0.010538681,0.09113369,-0.007153431,-0.08251387,0.0017243226,-0.058209002,0.018634234,-0.02063914,-0.010707983,-0.0021901396,-0.042866256,0.041687068,0.039648682,0.12153581,-0.038666934,-0.042137995,-0.051391013,0.11515539,-0.027453134,-0.023886189,0.061139792,-0.098919965,-0.030196754,0.06633552,-8.392522e-05,0.043519296,-0.09742705,-0.10252485,-0.0007124195,0.010928422,0.032853108,0.023664594,-0.009065845,-0.010142516,0.03722412,-0.048732284,0.042881336,0.017498484,0.039161112,0.008909258,-0.029735463,-0.101250306,0.042629328,-0.035410687,-0.036826815,0.05944466,0.01616315,0.02396479,-0.0202956,-0.16064565,-0.004839904,0.08776349,0.026940895,-0.063891545,-0.016750386,-0.06800711,-0.010590593,0.040006276,-0.044982526,0.011307369,-0.07373525,-0.013079192,0.063213326,0.10104612,-0.058843154,0.055555075,0.047872644,0.019628188,-5.7372665e-33,0.060377996,-0.047816385,0.071249,0.04848149,0.0808908,0.030624976,0.074483365,0.03262072,0.03987394,-0.03572793,0.052784607,-0.093693554,0.059625566,-0.039159827,-0.00038644497,-0.012275096,0.0048683514,0.057195622,0.034785394,-0.021120613,0.0011157315,-0.12967071,0.049541805,0.047702532,-0.04411787,0.04120547,0.01187446,0.051848672,-0.034760423,-0.006452252,-0.076629855,0.012976484,-0.04076915,0.008922929,-0.055026688,0.05271138,0.0031886192,-0.079074696,0.087704234,-0.08955748,-0.0051617683,-0.03284044,-0.019962508,0.057359148,0.057104114,0.16599339,-0.0045242463,0.040850468,0.011833875,-0.021708349,0.02401848,0.034943465,-0.13590291,-0.040202864,-0.09726723,0.060668986,0.07535056,0.017150834,0.08314075,0.022950059,-0.016788304,0.021802817,-0.010236014,0.011694941,-0.015160033,0.038001683,0.07734674,0.07183598,0.028800651,-0.07261779,0.08719587,-0.03179464,0.08960455,-0.051604263,0.05934072,-0.002181259,0.020448133,0.0019015623,0.015061469,-0.066144094,-0.0468062,-0.042166285,0.029639408,-0.068145774,0.07762234,-0.030109894,0.0015914529,0.03603583,-0.020625977,-0.0023848168,-0.056593463,-0.027481465,0.021667471,-0.0031262315,0.041898336,-4.105813e-08,0.1075681,-0.0018017361,0.011563782,-0.06262529,0.012129549,0.04601979,-0.056205202,0.059145063,-0.010938711,0.013741357,-0.026676707,-0.048568327,-0.0290781,-0.03150191,0.053102642,4.2509702e-05,0.0012278359,0.07353337,-0.001564239,-0.074140936,-0.025012657,0.017150868,-0.003509968,-0.0064230673,-0.036909707,-0.039464153,0.013620018,0.0011247618,0.05037031,-0.11470666,-0.013760624,0.0014114734,-0.05357796,-0.018078249,-0.016767336,-0.0016174344,0.013724357,-0.045916334,0.034393277,-0.029307075,-0.027107436,-0.0014715677,-0.08910477,-0.022335706,0.021429066,-0.012576694,-0.014983028,0.041344147,-0.004778409,-0.059371144,-0.034033675,-0.0860092,0.014104522,-0.08408468,-0.012583006,0.013567621,-0.016277306,-0.10007372,0.034833647,-0.09982909,-0.06970736,-0.08015921,0.06419298,0.021761073 +2.5.1.153,"The enzyme, characterized from the bacterial pathogen Mycobacterium tuberculosis, produces 1-tuberculosinyladenosine, an unusual terpene nucleoside that acts as a phagolysosome disruptor by neutralizing the pH, resulting in swelling of the lysosome and obliteration of its multilamellar structure.",384,1.0,-0.022258246,-0.07574896,-0.054396298,-0.020492624,-0.002540241,0.01693023,-0.0046506217,0.14917085,0.042239927,0.057172205,-0.01085116,-0.0012739364,0.05779372,0.09129614,-0.038914036,0.034562804,-0.06886453,0.010434833,0.003727607,-0.035658397,0.044174317,0.14178917,0.01656127,0.01021793,0.07313786,-0.0037899164,0.032738686,0.017252818,-0.027056305,-0.06757383,-0.046083786,-0.0120890215,-0.018561803,-0.067039,0.097908914,0.037170634,-0.054627173,-0.024820779,0.16472597,-0.004367257,0.042902116,-0.07826015,0.024747487,-0.04479721,-0.016092625,0.041954365,-0.038056783,0.09849232,0.082735434,0.041036576,-0.0015968829,-0.06599065,-0.054642215,0.059530675,-0.028939603,-0.021702548,-0.044013537,0.023545336,0.033277944,0.05985029,-0.0038989133,0.01467914,0.07990086,0.08024525,0.036698498,-0.039795507,-0.07151821,-0.03176889,0.052080434,0.00523966,-0.013719771,-0.053902235,-0.09019829,0.06685454,0.017597899,-0.047837835,0.016836274,-0.03163307,-0.029780071,0.10376395,-0.00968742,0.022320196,0.032188963,0.021224286,0.056127172,0.022498213,0.07306574,0.02761672,0.040948037,0.04064609,0.039972566,0.015194529,0.01029496,0.040665057,-0.03964009,-0.060720734,0.05521626,0.001558663,-0.056825664,-0.030645983,0.024437625,-0.01980825,0.014404462,-0.0314799,-0.008833187,0.031256605,0.0069196452,-0.05547864,0.041432794,-0.030127684,0.014155777,-0.02058274,-0.0013348426,-0.048229538,-0.033626188,0.06764458,0.08314651,-0.030701322,-0.05362262,-0.0016266473,0.010708435,-0.11915775,-0.026451098,0.03304399,-0.12379135,0.026029456,-0.04722388,2.876943e-33,-0.0054417355,-0.05109551,-0.034622617,0.018513596,0.023794265,-0.0018055263,-0.019718846,-0.011011878,-0.08001039,-0.059857614,-0.04858733,-0.048168544,0.034413274,0.11694901,-0.09245101,0.03444452,-0.0029263394,0.0424342,0.07478254,0.03569288,0.0014857216,0.037274618,-0.01428458,0.022163939,0.046797212,0.06685938,-0.06435574,0.03410625,0.04628887,-0.005781205,-0.0025882355,-0.052211225,-0.07500374,-0.0043528904,0.015204882,0.0049859565,-0.12151022,-0.01346367,0.026607735,0.02036033,-0.05416434,0.013660286,-0.045354676,-0.01133793,0.05904423,0.012033113,-0.03672662,0.038911935,-0.067792535,-0.056481197,0.06350029,0.019299794,0.025586842,-0.02922451,0.024711289,-0.020532856,0.045546908,0.024516089,0.0016025235,-0.0109031135,0.062162146,0.078528695,-0.04986267,0.082257144,-0.031028155,-0.020768376,-0.033130173,0.0065257307,0.02220646,0.00071639306,-0.055837303,0.038044237,0.024764378,-0.10331236,0.050304193,-0.008918282,-0.06580446,-0.056508087,0.045825873,-0.06512841,0.02168,-0.061181165,0.017991101,-0.07556274,-0.051581945,-0.030273331,-0.006725465,-0.06042827,-0.036518242,-0.031690054,0.06545662,-0.03740115,-0.091080636,0.10172992,-0.048249576,-4.1965435e-33,0.068429545,-0.11087974,0.0449464,-0.043704953,-0.044554587,-0.043596387,-0.016820235,-0.0401766,0.0017384716,0.015670972,0.06607515,-0.0267451,-0.029882923,0.015329589,0.034688763,-0.019223245,0.040627297,0.0030975721,-0.042749926,-0.018424274,-0.047403805,0.047401477,0.027181288,-0.040077757,-0.03993613,0.015401865,-0.041176528,-0.06866686,0.05260589,0.08049784,-0.05723227,-0.0059467116,0.016486228,-0.07992958,-0.083146356,0.019480646,-0.018480828,-0.06614472,0.113004684,-0.035422876,0.039591976,0.03210711,-0.033706423,-0.010723337,0.014546408,-0.028770886,-0.034740444,-0.017194534,-0.0062680813,-0.073197335,0.02017851,0.0073043285,0.07048135,0.032704435,0.022949733,0.044324994,-0.014575987,-0.0085659865,0.057920337,-0.0977717,-0.08502682,-0.07863269,-0.029544532,0.014478941,0.04231708,0.07051525,-0.064023525,0.05655698,0.056201544,-0.039540123,0.041306466,0.057353705,0.0070111384,0.0038188405,-0.005172461,-0.046418887,-0.057540234,-0.04069702,-0.008157289,0.02088995,-0.08191946,-0.012851847,0.012384914,-0.07780036,0.05230427,-0.113418534,0.022461016,0.12598282,-0.0572276,0.048733555,0.062223986,0.045940515,-0.07772265,0.08713506,0.091568574,-3.720157e-08,0.024402307,-0.016623445,-0.020681528,-0.008763344,0.05020428,-0.029974233,0.025393339,0.037617136,0.07252894,0.033893216,-0.009568757,0.083361655,0.032556813,-0.023838079,0.09372498,0.06815233,-0.11000076,-0.08763417,-0.0013573597,-0.051961076,-0.01904438,-0.012367821,-0.021659443,0.011452101,-0.051762618,-0.023585772,0.012684685,0.04552903,-0.042142693,0.0023551567,-0.04045829,0.039643392,-0.029318219,-0.095746405,-0.11049509,0.026821207,-0.008590068,-0.04044017,0.04739626,0.030518984,0.02331685,-0.023843622,-0.044258136,0.025960578,0.0001875592,0.008993872,0.034217574,0.010224676,-0.010059137,-0.044887736,0.03163203,-0.014471032,-0.024105197,0.059588615,-0.0006240713,0.038421094,-0.025075959,0.08185927,-0.06356715,-0.038436703,-0.04083417,0.014023278,0.21369177,-0.05741442 +3.1.1.115,"The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose.",384,1.0,-0.010717851,-0.049822982,-0.011911123,-0.03040062,-0.017747216,0.00010416002,-0.07669161,0.02012189,0.035755288,0.07740424,-0.0058297324,-0.031696104,-0.042020656,0.082912594,-0.02210022,0.043449588,-0.084883094,0.031416588,-0.032128934,-0.009902853,0.10729442,0.052869167,-0.012106387,-0.06035086,0.03928096,-0.03481488,0.097833104,-0.022893658,-0.05446615,-0.046231274,-0.025056941,-0.046470374,0.03025056,-0.004232167,0.07550718,0.045013174,0.026931433,-0.037550174,0.06979521,0.0002979943,0.0018248165,-0.01211736,0.010437837,-0.014509574,-0.069328904,0.014629447,-0.07254768,0.020688102,0.012070894,-0.020146746,-0.051223747,-0.06265584,-0.038105544,0.007907252,0.046322744,-0.013994073,0.0018091127,0.01128746,-0.05245691,-0.062032823,0.068182275,0.01348,0.06940905,0.05410239,0.02082399,-0.040322073,0.009222289,-0.026207337,0.015828568,-0.081414975,-0.066444404,-0.10101094,-0.042791594,0.030849587,0.016673585,-0.031250432,0.044307943,-0.04927883,0.014138358,-0.094823495,0.047390208,0.055806044,0.024258235,0.10644971,-0.014648772,0.05180601,0.034623142,-0.037972912,0.042213142,0.013019836,-0.013808782,-0.06993193,-0.016979255,-0.086577676,-0.065138444,-0.018036421,0.0132194385,0.015465527,0.027334405,-0.0383427,-0.051050585,0.08654528,-0.02624758,-0.060548257,-0.05653179,-0.0024408116,-0.021349544,0.0729144,0.022864882,-0.03323822,0.03825701,0.021634515,0.069731735,0.078542136,-0.030713027,0.044235587,0.023645664,-0.050945632,-0.019512856,0.0149498535,0.004109745,-0.04993793,0.057325944,0.07167553,-0.044917382,0.03938547,-0.05100519,-3.9938695e-33,0.07701653,-0.023794277,-0.030638412,-0.011090716,0.054700103,-0.06879065,-0.048186816,0.012923736,-0.11778397,0.018220795,-0.15511115,-0.1007017,0.036854904,0.05468623,-0.0045858747,0.022027943,-0.014177172,-0.0036069485,0.020038193,0.019473074,0.020169104,0.053896114,-0.009435582,-0.023028785,0.02476515,0.06042219,0.012546169,0.09858029,0.01398474,-0.027254311,-0.006783864,-0.1024362,-0.037233513,0.02785199,0.026910445,-0.019657854,-0.0072459285,0.020525083,-0.018132523,0.024871124,0.024905136,0.04629143,-0.008859157,-0.023136783,0.0394961,-0.0012132374,-0.0339609,0.07268619,0.010438631,0.08632905,0.092489235,-0.020120462,0.12285258,-0.038176153,-0.05616376,0.0071428623,-0.05646787,-0.029924996,0.0164776,0.03078253,-0.00479683,0.037105337,-0.06625272,0.08103661,0.03915977,0.014263465,-0.014566244,-0.01851812,0.024279056,0.090695165,-0.1187731,-0.010497617,0.047585413,-0.04230578,0.040251736,-0.076674886,-0.039990775,-0.024372483,0.042019125,-0.02130802,0.0077507054,-0.03755073,-0.027281096,-0.015982693,-0.072845206,0.009274025,-0.059099857,-0.09926928,-0.09184678,0.013841298,0.024215762,-0.04780377,-0.119405456,0.048047576,0.045484066,1.4279508e-34,0.0778154,-0.07032939,0.030871175,-0.077386804,-0.07655724,0.095090166,0.03670491,0.013066646,0.056751624,-0.0006645797,0.05303063,0.013489484,-0.017746104,0.0016793001,-0.003573258,0.042660024,-0.06777031,0.003554347,-0.044262774,0.020602323,-0.04851769,0.060449548,-0.04531839,-0.060517613,0.06152449,0.035554234,-0.018344866,0.12168652,-0.02840862,-0.030420186,0.108481854,-0.0045988,0.013682968,-0.048063364,-0.069774665,0.08812652,-0.03438365,-0.0049199252,-0.023329223,-0.00044240407,-0.05136399,0.003480292,-0.025555406,0.054521732,0.023885954,0.048342187,-0.085009284,0.03938795,-0.03643135,-0.028672645,0.004124278,-0.021775996,0.09065494,0.008005356,-0.008785739,0.0957443,0.03348529,0.05117546,-0.06483976,-0.003127295,-0.004184873,-0.08322043,0.11665395,0.07666103,0.022315245,0.0140080005,-0.018467838,0.008842762,-0.003223858,-0.010541085,0.022375239,0.0027057254,-0.042516734,0.002966779,-0.05382427,-0.09023432,-0.10948875,-0.035995107,0.046536103,0.06263136,-0.07107655,0.008004547,-0.008434132,-0.011111123,-0.043672547,-0.09514481,0.008956947,0.106147505,0.022168143,0.104298085,-0.035483494,-0.0016768256,-0.03466647,-0.033735033,0.067319535,-2.5831124e-08,0.08542653,-0.01929264,-0.01359266,-0.021792503,0.038532306,0.011132611,-0.058415875,0.05714077,0.02206284,-0.0017790925,-0.010178985,0.080340855,-0.048065282,-0.001675583,0.070747524,0.015285095,-0.010330647,-0.01811317,-0.041365676,0.045288663,-0.073043406,-0.023053698,-0.12849712,-0.010645281,0.063466996,-0.06115019,0.05639673,0.054209683,-0.040427893,0.0164932,-0.026698494,0.021653099,0.003605495,-0.085222244,-0.08002988,0.035508953,-0.044249337,-0.06906885,0.042407002,0.04021889,0.078987576,-0.002468166,-0.034184042,0.021645082,0.0027152158,0.055025183,-0.015074819,0.022938306,-8.507582e-06,0.026177434,0.0013389833,-0.007163909,-0.049714074,-0.047170505,-0.13254347,0.049410265,-0.032775667,-0.06215822,-0.013120193,-0.031864483,0.060498208,0.041190848,0.18664815,-0.057582177 +3.5.1.136,"The enzyme, characterized from the archaeons Thermococcus kodakarensis and Pyrococcus horikoshii, deacetylates the non-reducing residue of N,N'-diacetylchitobiose, the end product of the archaeal chitinase, to produce beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine. This is in contrast to EC 3.5.1.105, chitin disaccharide deacetylase, which deacetylates N,N'-diacetylchitobiose at the reducing residue to produce N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine.",384,1.0,-0.050147332,-0.108073555,-0.03031903,-0.048601728,0.0040115803,0.005392524,-0.017672924,-0.013148758,0.04516435,0.07032144,0.040536836,-0.0028141704,-0.031404555,0.06341349,-0.136259,-0.022014674,-0.023154901,-0.059173252,-0.024116466,0.023606813,0.12121047,0.032213766,-0.00842519,0.004937451,0.023691507,0.041847404,0.05679313,-0.0633509,-0.02193959,-0.045510937,-0.02561704,-0.0859214,0.05605469,-0.030120045,0.04223606,0.039707225,-0.008320977,-0.005611721,0.12533396,0.042373788,0.0067340545,0.014203923,0.0019114201,0.032115933,-0.0017330955,0.0050236043,-0.024703093,0.059463043,0.06177695,-0.056022275,0.0063631474,0.03074187,-0.03217222,0.0033185286,0.041310646,0.08122958,-0.027147494,-0.10015826,-0.023367425,0.036347438,0.06625614,0.024543727,-0.01708316,-0.055927135,-0.031342458,-0.0610614,0.051303864,-0.10109071,0.025751563,0.017580181,-0.09088137,-0.013227888,-0.026470246,0.0241855,0.048438888,0.03920857,-0.014984386,-0.03175054,-0.010697991,-0.06291872,0.06926075,0.008791906,0.013210599,0.087148726,-0.005153446,-0.042293616,0.018405797,-0.0065341643,0.08956977,0.004442161,-0.0021120028,-0.077031925,0.011940881,-0.06595265,-0.08001857,-0.0828201,-0.0057245707,0.049937192,0.027479269,-0.010598166,-0.016091987,-0.020518893,0.001296359,-0.12528935,-0.05115407,0.05797825,0.060275175,0.10333321,0.095838346,0.06336471,-0.006582646,0.08252001,-0.0360837,0.044338327,-0.087062836,0.08519217,0.042901173,-0.10276712,-0.028524932,0.0031877041,0.017686518,-0.018548662,0.0691162,0.087279394,-0.100314915,0.06206534,-0.08096476,2.4808432e-33,0.0017708314,-0.027630417,0.041842047,-0.070013136,0.033985898,-0.02294769,-0.10294285,-0.036065202,0.05571627,-0.033979654,-0.06751885,-0.01891583,0.000121993246,0.06263871,-0.010408739,0.10947346,0.006922299,0.034928255,0.049469065,0.0005785459,-0.04480777,0.11880538,-0.03464779,-0.0035569938,0.13520376,0.024014438,-0.029560102,0.022593698,0.04525344,-0.016067592,0.08451801,-0.08102553,-0.051588852,-0.028000971,0.046439216,0.022282002,0.00039125237,-0.01935698,0.024040682,0.0037805617,0.005583409,0.060047347,-0.034232274,-0.022648266,0.035420943,-0.03383179,0.02808159,0.055252444,-0.055205137,0.057485398,0.023894079,-0.0346548,0.08669178,0.022870967,-0.049937047,-0.000198722,-0.00460926,-0.050890997,0.12228435,0.048002094,0.00872349,0.044793643,-0.030342136,-0.01232891,-0.008039884,-0.021084167,0.008021931,0.007790826,-0.021910926,0.008782377,-0.054429542,-0.043823346,0.0019755887,0.020935552,-0.0009619122,-0.101371944,-0.092000976,0.026869617,-0.0059393025,-0.02645717,0.040586006,0.031969685,0.023515373,-0.015625618,-0.034534402,0.065990016,-0.0036168625,-0.022204516,-0.0022990813,0.010446671,-0.02572304,-0.017805003,-0.059655547,0.038757555,0.0013039216,-3.0006611e-33,0.10874151,-0.12001614,0.023832826,-0.013008777,-0.07399091,0.076195806,0.00087728293,0.008271961,-0.047163837,-0.09970944,0.051330447,0.022966428,0.018725192,-0.032827668,0.036091853,-0.05741209,-0.0631762,0.069187924,-0.021110255,0.04852014,0.02225398,0.026297865,-0.012213914,-0.058442563,0.03767349,-0.00073031674,0.016107941,0.12747422,0.00883936,-0.0009476456,-0.0096209925,0.037984163,-0.012958753,-0.09372055,-0.063623615,-0.00058408483,-0.03769013,-0.0021117693,-0.028556032,-0.007938216,-0.007460182,0.049613904,0.026545858,0.00588581,0.0037477172,0.04169518,-0.03339047,-0.03162199,-0.017207542,0.0011994588,0.051218282,-0.04578125,0.007460252,0.005898052,0.0085635455,0.08447899,0.031218274,0.09763955,0.043319017,0.001647578,-0.040234,-0.011072719,0.060313147,-0.013947788,0.077340834,0.07651102,-0.04191869,0.1379362,0.039418392,-0.034505367,-0.05576026,0.020988008,0.030216316,0.013917937,0.029270848,0.023755176,-0.1158202,-0.040008985,0.02795041,-0.0040810145,-0.0123047205,-0.04853381,-0.038502708,-0.042806897,-0.030953871,-0.00973898,0.06454355,0.093972385,-0.07685793,0.09175395,0.022396157,-0.08447212,-0.03855988,0.043514483,0.06285275,-4.2197254e-08,0.08094571,-0.017425897,0.01941958,-0.045435913,-0.024657877,-0.0019570512,0.009372782,0.032913283,0.03460758,-0.06177714,0.05816481,0.057269428,-0.046776645,0.07296379,-0.03004059,0.016488016,-0.056145873,-0.010419462,-0.010379624,0.046453077,-0.06779236,0.04055264,-0.0955633,0.013949255,-0.0038410062,-0.0676682,0.06075246,0.056203544,-0.073791705,-0.06447367,0.014826901,0.06520691,-0.050952245,-0.08579141,-0.039326295,-0.018299676,-0.07951057,-0.05318633,0.03279975,0.01382324,0.002087176,0.0410785,-0.0587076,0.0055592554,0.026056956,-0.003144711,-0.022500588,0.053124625,-0.023892364,0.027908338,0.03249527,0.001519717,-0.035933804,-0.12056648,-0.13311087,-0.0010274684,-0.0042141816,-0.060845155,-0.029986408,0.00687307,0.03045501,-0.087516636,0.10368126,-0.006057624 +3.7.1.27,"The enzyme, characterized from Glycine max (soybeans), is specific for neryl diphosphate.",384,0.99999994,-0.10199153,-0.049689356,-0.03473072,-0.10590284,-0.018114952,0.01023998,-0.06691664,0.058355194,-0.039437346,-0.04730723,0.07906153,0.013922006,-0.04243673,0.046911966,-0.061958633,0.019625664,0.089841545,-0.007832716,-0.021877931,-0.077215366,0.07438204,0.05245556,-0.06500906,-0.09683388,0.042592105,-0.025951954,0.013216925,-0.0511237,0.023262134,-0.052876342,-0.06721509,-0.040424224,0.03712652,-0.053515114,0.066135004,0.070712455,-0.08240201,-0.075270124,0.051406074,0.04752045,0.05593475,0.008495691,0.022938706,-0.04494049,-0.066605605,-0.018813906,0.023667963,-0.006356047,0.070595376,0.024494953,-0.05325285,-0.028113443,-0.017732065,-0.025729667,0.04313542,-0.025871146,-0.04341081,-0.01701137,-0.08602806,0.023421375,-0.021660434,0.0164984,0.004415044,-0.019300137,0.06475437,-0.03589754,0.024251577,-0.033783145,0.006004741,0.008181247,-0.009394834,-0.084655546,0.041797325,-0.0036112582,-0.05313618,0.0063393456,-0.04709338,0.060160983,0.096518494,-0.047604717,-0.0044551454,-0.055371467,0.045504924,0.0028400263,0.018418133,0.0510133,-0.032128386,0.07492154,0.07486861,0.025178434,-0.00020129733,0.0039717196,-0.068107694,-0.0024587507,-0.053530093,0.06043659,-0.030519646,0.029752804,-0.045132436,-0.020620134,0.05425946,0.03752207,-0.035666138,-0.066933006,-0.04009026,0.0134371,-0.035362836,0.021555757,0.0072131422,0.009939763,-0.032714263,0.08541092,0.05344141,-0.0031004779,-0.04477574,0.05893369,0.04034696,-0.00087494485,-0.028213019,-0.020541636,0.07183813,0.031364374,0.05982932,0.07032862,0.0043155123,0.13894778,-0.08054085,-7.415034e-34,0.07627967,0.011337189,0.071375825,-0.04419699,-0.03849913,0.04935709,-0.10362617,0.054514907,-0.057015583,-0.06281809,-0.055479508,-0.051485494,0.029663442,0.023895329,-0.024998248,0.038334787,-0.024633847,-0.036720153,0.075819805,0.0012747986,0.07132494,0.037593514,-0.05748408,0.021550976,-0.0220689,0.009646803,0.010505507,0.019681793,-0.033160243,-0.015023985,0.005921288,-0.1307261,-0.04970164,0.05276153,0.05143893,-0.009560534,0.0011135931,-0.049269464,-0.02402789,-0.00017671837,0.0077328174,0.0241604,0.059065014,-0.050841115,0.029090803,0.0048519154,-0.023050763,0.04198537,-0.012025932,0.010439916,0.009513646,-0.03192994,0.10132122,-0.020096688,-0.0074393717,0.02384429,0.02168025,0.036381558,0.013532041,0.044641193,-0.076913275,0.015030424,-0.042702477,0.007406798,0.022804152,0.040715966,-0.09915065,-0.008508316,0.04530038,0.11944016,0.025050493,-0.03064273,0.08083406,0.055524677,-0.057926916,-0.077307545,0.015645206,0.008842129,-0.027053935,0.041182358,0.041459356,0.009506294,0.004770212,-0.04040121,-0.11842819,-0.0026160944,0.030249834,-0.042777892,0.010513381,-0.014406157,0.11237255,-0.008437377,-0.11541357,-0.0240755,-0.027937822,1.3912573e-34,0.08847427,-0.077129535,0.02746733,-0.005666158,-0.012957492,-0.07179472,0.10368824,0.00975711,0.026544511,-0.07024625,0.04589358,-0.00617198,0.021112442,-0.03808744,-0.037507348,0.05995157,-0.056097202,0.026717598,0.030713568,-0.045694903,-0.06647571,0.092494994,0.027184667,0.066463456,0.083814874,0.0012603913,0.0012390397,0.115467355,-0.062340796,0.026642364,-0.009348888,0.013128811,-0.07865206,0.015129451,-0.009445728,0.033496175,-0.042140234,-0.02458032,0.041519806,-0.011074642,0.008458169,0.1126579,0.020624256,0.082348965,-0.016317526,0.07422228,-0.08224462,0.021580504,-0.03798639,-0.075229235,-0.0387528,-0.037904125,0.04701944,0.03667751,0.028590083,0.0031737199,0.021093037,0.0062300796,-0.014083557,0.037527107,0.043398764,-0.019094573,-0.032797847,-0.005858431,0.029719073,0.06881042,-0.013955089,0.0510177,-0.00013920909,0.06555684,0.048074786,0.016901264,0.08674368,0.053950496,-0.023164831,-0.010898163,-0.013576558,0.025826968,-0.04795091,-0.08886935,0.008639256,0.029548153,-0.06647002,0.01976564,0.0049314247,0.028858067,-0.05324381,0.14096288,0.11524428,0.024999961,-0.08058346,-0.025378732,-0.09919836,0.085415095,0.0779145,-2.211788e-08,0.030951671,-0.08789287,0.015194347,-0.10566204,0.011487077,0.06862437,0.0048222826,-0.025474938,0.09747664,0.04069897,-0.040368967,0.068431996,-0.060180087,0.0028579168,-0.04585502,0.013456923,0.011384364,0.05470679,-0.025320468,-0.016733622,-0.06177387,0.048135363,-0.15409595,0.033512108,-0.010320539,-0.018160429,-0.013229572,0.06498358,0.04497865,-0.058354992,-0.052024078,0.0038861919,0.031008549,-0.081366375,-0.07531212,0.079780504,-0.02892562,0.011484814,0.0050687734,0.00013838515,-0.008460862,-0.031119965,-0.029766083,-0.017016945,-0.032156017,-0.048271608,0.0012458016,0.019987565,0.035749342,0.051996965,0.0010858623,0.011281578,0.008679925,-0.05119466,-0.10103203,-0.065192804,-0.066642955,-0.018422564,-0.0030206954,-0.04464303,-0.0124306325,0.022125551,0.17423332,0.003996537 +5.1.3.44,"The enzyme, characterized from multiple bacterial species, catalyses the interconversion between beta-D-glucopyranose and beta-D-mannopyranose through proton abstraction-addition at the C2 position.",384,1.0,-0.009533575,-0.091410115,-0.07142876,-0.036133498,-0.0032489283,0.038205057,-0.026262352,0.0036375732,0.018833393,0.03738986,0.0064327624,0.020533925,-0.068350844,0.026097557,-0.034199286,0.035832126,-0.053184208,0.0019562123,-0.03148976,-0.01818833,0.01936561,-0.05002006,-0.0045283535,-0.0018349632,0.08928011,0.043520816,0.03539704,-0.0093547115,-0.038821112,-0.07025732,-0.010982972,-0.10652965,0.049548354,-0.011391805,0.089538336,0.021133168,-0.02045333,-0.01419094,0.10461113,-0.02077121,-0.00890043,-0.013211485,-0.003917433,0.0065258658,-0.04987382,0.044120293,-0.04371797,0.06189988,0.07475131,-0.02413574,-0.0019487818,-0.065963365,-0.07928163,0.013417611,0.011515432,0.072366275,0.0064595146,0.0040783663,0.03490604,-0.0031677373,0.021500291,0.048116367,0.07209804,0.044459328,0.01107944,-0.055625048,0.013855146,-0.013381369,0.048029337,0.0028817325,-0.040497083,-0.059566945,-0.058605857,-0.039171223,0.04060581,-0.047594637,0.02534075,-0.07504995,0.039218053,-0.015697766,0.045963645,0.040795937,0.022390816,0.0012035435,-0.03485124,-0.039668962,0.018399311,0.032497346,0.11512296,-0.034176897,0.00970183,-0.03141913,-0.03460975,-0.100204274,-0.015832072,-0.00030419638,0.03872001,0.035770312,0.04718132,-0.004512152,0.028927555,0.0019709417,-0.004921126,-0.09604594,-0.03397085,0.03668008,0.008365568,0.078730084,0.017698586,-0.016122887,-0.013241394,0.029909765,0.036195427,0.023672951,-0.12613991,0.07689859,0.08517399,-0.04108566,-0.027659617,-0.015039501,0.094309054,-0.05113605,0.060427867,0.05654301,-0.06136069,0.036112837,-0.07983307,-8.150384e-34,0.037462797,0.008916909,0.059333935,-0.019440446,0.037480775,-0.010960395,-0.10635329,-0.059030496,-0.10332588,0.064038835,-0.09180171,-0.09807592,-0.014697174,0.08156149,-0.045925982,0.14150971,-0.0072938264,0.07154417,0.0005265679,0.036111064,0.015898898,0.07297019,-0.007989979,-0.00933252,0.08889059,0.082253695,-0.01998245,0.10044741,0.0786532,-0.016886499,0.017778125,-0.03278681,-0.072389826,0.022218132,0.035549495,0.008712977,-0.07657631,-0.070510484,0.07434447,-0.006027068,0.026325062,0.0028549696,-0.034628924,-0.054919004,0.036945105,-0.022456424,-0.0024763686,0.026654918,-0.01397077,0.05834673,0.0013285148,-0.06023216,0.05361929,0.048782453,-0.011758498,0.030395206,-0.0668461,-0.038296614,0.0985337,0.032125022,-0.026937334,0.021905798,-0.046166554,-0.02651,0.037581526,-0.011764818,-0.03436859,0.054483805,0.010017066,0.052225836,-0.07134422,-0.0301774,-0.009228811,0.013144779,0.0045685675,-0.060865533,-0.03937587,-0.07791853,0.08427364,-0.023001362,-0.027086832,0.024810242,0.0016897984,-0.03702999,-0.05854381,-0.029046286,-0.08898929,-0.0443406,-0.041109823,0.05203465,-0.06657963,-0.03037592,-0.122777216,0.030517083,0.013511697,-2.0162448e-33,0.06253165,-0.085766256,0.057286322,-0.08613733,-0.06411824,0.024835804,0.02245676,-0.15744525,-0.0113256145,-0.015297415,-0.0034609812,0.0024516438,-0.07255034,-0.07212554,-0.0073559694,-0.008290273,-0.006580147,0.08094445,-0.029932996,0.036334258,0.043542456,0.013811247,0.0602492,-0.022355918,0.039613202,-0.06219247,-0.019734997,0.075057,0.08655778,0.09382638,-0.0066399425,-0.0039693057,0.01805412,-0.039189544,0.01918855,0.068176724,-0.06200009,0.04159779,0.04477712,-0.011550752,-0.033569623,0.06707097,-0.0360902,-0.03189054,0.06501194,0.10355775,-0.070496455,0.035912097,-0.01968633,-0.077126265,0.023876227,-0.045676094,-0.016436499,0.01684904,0.020924922,0.04245987,-0.019012867,0.052725725,-0.010381948,-0.10914991,-0.048734188,-0.097117074,0.035771027,-0.065487266,0.048296954,0.06191221,-0.017478306,0.062048946,0.024039065,0.0077041443,0.013002284,-0.023557562,-0.022149524,0.03980924,-0.01797141,-0.046693094,-0.0857874,-0.06504923,0.06529742,-0.006642861,-0.011563854,0.021451235,-0.0058183246,-0.028836459,0.0022032217,-0.01542874,0.040557545,0.17021836,-0.0070866216,0.038439136,-0.038082488,0.041949604,-0.01732142,0.066982284,0.030638063,-3.085452e-08,0.09832095,-0.028776186,0.046240848,-0.0757462,0.008123217,0.014224512,-0.057135306,0.0011925668,0.016478462,-0.029988935,0.00047000294,0.08201239,0.019681603,-0.0049784635,0.00603613,0.03754052,-0.08212918,0.0016214056,-0.03249711,0.044859383,-0.078124724,0.05508106,-0.12589806,0.022063214,-0.011264828,-0.044029083,0.053051583,0.06996939,-0.087350264,0.013151074,0.06484448,0.041900333,-0.052175965,-0.029942362,-0.006134353,0.011263496,-0.05332022,0.004642658,0.059438843,-0.032073133,0.042320844,-0.00091136765,-0.020645874,0.011112216,-0.022190586,0.039982516,-0.039035317,0.005668436,-0.05826438,0.07983725,0.09752581,-0.007565211,-0.05991034,-0.08275685,-0.10184062,0.0141174365,-0.008895334,-0.04313439,-0.014549657,-0.05084618,0.044691768,-0.06907937,0.13137756,-0.03180653 +5.3.1.36,"The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose.",384,1.0,-0.010717851,-0.049822982,-0.011911123,-0.03040062,-0.017747216,0.00010416002,-0.07669161,0.02012189,0.035755288,0.07740424,-0.0058297324,-0.031696104,-0.042020656,0.082912594,-0.02210022,0.043449588,-0.084883094,0.031416588,-0.032128934,-0.009902853,0.10729442,0.052869167,-0.012106387,-0.06035086,0.03928096,-0.03481488,0.097833104,-0.022893658,-0.05446615,-0.046231274,-0.025056941,-0.046470374,0.03025056,-0.004232167,0.07550718,0.045013174,0.026931433,-0.037550174,0.06979521,0.0002979943,0.0018248165,-0.01211736,0.010437837,-0.014509574,-0.069328904,0.014629447,-0.07254768,0.020688102,0.012070894,-0.020146746,-0.051223747,-0.06265584,-0.038105544,0.007907252,0.046322744,-0.013994073,0.0018091127,0.01128746,-0.05245691,-0.062032823,0.068182275,0.01348,0.06940905,0.05410239,0.02082399,-0.040322073,0.009222289,-0.026207337,0.015828568,-0.081414975,-0.066444404,-0.10101094,-0.042791594,0.030849587,0.016673585,-0.031250432,0.044307943,-0.04927883,0.014138358,-0.094823495,0.047390208,0.055806044,0.024258235,0.10644971,-0.014648772,0.05180601,0.034623142,-0.037972912,0.042213142,0.013019836,-0.013808782,-0.06993193,-0.016979255,-0.086577676,-0.065138444,-0.018036421,0.0132194385,0.015465527,0.027334405,-0.0383427,-0.051050585,0.08654528,-0.02624758,-0.060548257,-0.05653179,-0.0024408116,-0.021349544,0.0729144,0.022864882,-0.03323822,0.03825701,0.021634515,0.069731735,0.078542136,-0.030713027,0.044235587,0.023645664,-0.050945632,-0.019512856,0.0149498535,0.004109745,-0.04993793,0.057325944,0.07167553,-0.044917382,0.03938547,-0.05100519,-3.9938695e-33,0.07701653,-0.023794277,-0.030638412,-0.011090716,0.054700103,-0.06879065,-0.048186816,0.012923736,-0.11778397,0.018220795,-0.15511115,-0.1007017,0.036854904,0.05468623,-0.0045858747,0.022027943,-0.014177172,-0.0036069485,0.020038193,0.019473074,0.020169104,0.053896114,-0.009435582,-0.023028785,0.02476515,0.06042219,0.012546169,0.09858029,0.01398474,-0.027254311,-0.006783864,-0.1024362,-0.037233513,0.02785199,0.026910445,-0.019657854,-0.0072459285,0.020525083,-0.018132523,0.024871124,0.024905136,0.04629143,-0.008859157,-0.023136783,0.0394961,-0.0012132374,-0.0339609,0.07268619,0.010438631,0.08632905,0.092489235,-0.020120462,0.12285258,-0.038176153,-0.05616376,0.0071428623,-0.05646787,-0.029924996,0.0164776,0.03078253,-0.00479683,0.037105337,-0.06625272,0.08103661,0.03915977,0.014263465,-0.014566244,-0.01851812,0.024279056,0.090695165,-0.1187731,-0.010497617,0.047585413,-0.04230578,0.040251736,-0.076674886,-0.039990775,-0.024372483,0.042019125,-0.02130802,0.0077507054,-0.03755073,-0.027281096,-0.015982693,-0.072845206,0.009274025,-0.059099857,-0.09926928,-0.09184678,0.013841298,0.024215762,-0.04780377,-0.119405456,0.048047576,0.045484066,1.4279508e-34,0.0778154,-0.07032939,0.030871175,-0.077386804,-0.07655724,0.095090166,0.03670491,0.013066646,0.056751624,-0.0006645797,0.05303063,0.013489484,-0.017746104,0.0016793001,-0.003573258,0.042660024,-0.06777031,0.003554347,-0.044262774,0.020602323,-0.04851769,0.060449548,-0.04531839,-0.060517613,0.06152449,0.035554234,-0.018344866,0.12168652,-0.02840862,-0.030420186,0.108481854,-0.0045988,0.013682968,-0.048063364,-0.069774665,0.08812652,-0.03438365,-0.0049199252,-0.023329223,-0.00044240407,-0.05136399,0.003480292,-0.025555406,0.054521732,0.023885954,0.048342187,-0.085009284,0.03938795,-0.03643135,-0.028672645,0.004124278,-0.021775996,0.09065494,0.008005356,-0.008785739,0.0957443,0.03348529,0.05117546,-0.06483976,-0.003127295,-0.004184873,-0.08322043,0.11665395,0.07666103,0.022315245,0.0140080005,-0.018467838,0.008842762,-0.003223858,-0.010541085,0.022375239,0.0027057254,-0.042516734,0.002966779,-0.05382427,-0.09023432,-0.10948875,-0.035995107,0.046536103,0.06263136,-0.07107655,0.008004547,-0.008434132,-0.011111123,-0.043672547,-0.09514481,0.008956947,0.106147505,0.022168143,0.104298085,-0.035483494,-0.0016768256,-0.03466647,-0.033735033,0.067319535,-2.5831124e-08,0.08542653,-0.01929264,-0.01359266,-0.021792503,0.038532306,0.011132611,-0.058415875,0.05714077,0.02206284,-0.0017790925,-0.010178985,0.080340855,-0.048065282,-0.001675583,0.070747524,0.015285095,-0.010330647,-0.01811317,-0.041365676,0.045288663,-0.073043406,-0.023053698,-0.12849712,-0.010645281,0.063466996,-0.06115019,0.05639673,0.054209683,-0.040427893,0.0164932,-0.026698494,0.021653099,0.003605495,-0.085222244,-0.08002988,0.035508953,-0.044249337,-0.06906885,0.042407002,0.04021889,0.078987576,-0.002468166,-0.034184042,0.021645082,0.0027152158,0.055025183,-0.015074819,0.022938306,-8.507582e-06,0.026177434,0.0013389833,-0.007163909,-0.049714074,-0.047170505,-0.13254347,0.049410265,-0.032775667,-0.06215822,-0.013120193,-0.031864483,0.060498208,0.041190848,0.18664815,-0.057582177 +1.1.1.425,"Levoglucosan is formed from the pyrolysis of carbohydrates such as starch and cellulose and is an important molecular marker for pollution from biomass burning. This enzyme is present only in bacteria, and has been characterized from Arthrobacter sp. I-552 and Pseudarthrobacter phenanthrenivorans. cf. EC 2.7.1.232, levoglucosan kinase.",384,1.0,-0.058108382,-0.038748335,-0.09264429,-0.053010877,0.07293063,0.020148221,-0.020764766,-0.052734487,0.066759504,0.023691436,0.052454446,-0.03980363,-0.031225864,-0.021956593,-0.08699663,0.059624113,-0.08263774,-0.008833728,-0.03210913,0.012783256,0.08989522,0.048044935,0.0038071165,0.040481098,0.057738293,-0.060077824,0.01645989,-0.034377996,-0.054126322,-0.0059146653,0.060860213,-0.00033480802,-0.030502778,-0.029585766,0.06487969,0.042523507,-0.028248422,-0.09135825,0.09006626,-0.019649219,0.011514735,-0.111746274,0.003948433,-0.10605676,-0.0076328516,0.012867081,-0.038968146,0.0138293635,0.038728017,-0.051691886,-0.0044428916,-0.036181726,-0.027624069,-0.028296828,0.04289727,-0.03888491,-0.05889036,-0.045934994,0.017395683,0.00632325,0.010485676,0.08173543,-0.052632283,-0.008371818,-0.03509802,-0.033319667,0.0043738107,-0.06779491,-0.005631767,-0.0009363312,-0.104234934,-0.018189508,0.050179645,-0.0019710432,0.025584469,-0.0159423,0.016737068,-0.039787248,0.03756098,-0.06274465,0.045613866,0.03135017,0.03896511,0.1051246,-0.08295771,-0.05280192,0.042321824,0.06883448,0.048228778,0.04841367,0.037036452,-0.012579617,0.03501706,-0.012135826,-0.013278024,0.05677731,0.07438305,-0.002649768,0.115423255,-0.06336982,-0.0497537,-0.0027194843,0.009671542,-0.16143686,-0.047135532,0.05155393,-0.009391939,0.04702868,0.084827654,-0.013853584,0.058039077,0.0678482,-0.05106367,-0.012531119,-0.038213488,0.045589022,0.040804412,-0.09359149,-0.09090765,0.0068457024,-0.022833075,-0.028824113,0.025628574,0.047760542,-0.036983784,-0.014881146,-0.09369652,2.7438057e-33,0.059100475,0.019071246,0.049053207,-0.03388175,0.023399508,-0.036261156,-0.036864154,-0.08505179,0.0056561837,-0.049994484,-0.078568324,-0.08524335,-0.036485188,0.10301505,-0.041081954,0.06554127,-0.06646737,-0.05372184,0.016647154,0.0230704,-0.04495147,0.095106155,-0.0019721028,-0.09435467,0.019651992,0.06024173,-0.05925351,-0.035879422,-0.050123222,0.012310578,0.1216705,-0.03530657,-0.10107611,0.06616773,0.09613318,0.028442122,-0.033869486,-0.040369753,0.017020699,0.027816791,0.018130695,8.13841e-05,-0.069348805,0.0052893343,0.020962898,0.04332435,-0.015999552,0.08822902,0.039410513,0.07458284,0.0439575,0.038774244,0.034904968,-0.060722105,-0.057095494,0.066814475,0.035887297,-0.06575612,0.090658985,0.059213057,-0.015780997,0.11797611,0.0130732525,0.048716784,-0.005785831,-0.038054198,0.0020476475,-0.008823987,0.01660163,-0.025422389,-0.013628581,-0.098421685,0.051295955,0.026431475,0.043439154,-0.010374232,-0.0037138462,0.019957285,-0.052439425,0.030396463,-0.017981282,0.011473827,-0.021885432,-0.12636375,-0.09663519,0.024392856,-0.06837059,-0.059002694,-0.033689965,0.07636534,-0.090899535,-0.03089951,-0.061532095,0.038070705,-0.013070691,-6.0573466e-33,0.09787089,-0.09787029,0.061057117,-0.019888213,-0.03217428,-0.0035486002,0.039162897,-0.036581717,0.02509125,0.111438885,0.071756266,0.03950582,-0.01777448,0.00475785,0.088242695,-0.029425563,-0.05590515,0.1052097,-0.054825738,0.0049907295,-0.040900268,0.06400589,0.0021106086,0.015605837,0.063575864,-0.007987093,-0.06070396,0.059775777,0.004876623,-0.06683521,0.057082906,-8.686502e-05,-0.015147539,-0.12322212,0.012887838,0.018513402,-0.029398525,-0.06048554,0.031974617,0.023896428,0.008902554,0.0016818049,0.009279039,-0.017293034,0.020579638,0.019793507,-0.04410025,-0.052288104,0.06094979,-0.012311868,0.077145204,0.027005263,0.023532782,0.0011990535,0.07439101,0.06901217,-0.003964687,0.035782732,0.0047483803,-0.02995803,-0.060425423,-0.03277065,0.059205886,0.073616415,0.0652337,0.011442092,0.02595081,-0.018423924,0.10471468,-0.005497956,0.025678435,0.007169637,0.01041733,0.05098491,-0.10635569,0.008666169,-0.06277441,-0.05485935,0.019232439,-0.021597868,0.04607561,7.7439494e-05,0.018200696,-0.071285024,-0.023646194,-0.09905922,0.05464896,0.03860027,-0.016090248,-0.010317243,0.044424403,-0.009645701,-0.06482584,0.03810935,-0.012344487,-4.2236824e-08,-0.0066046016,-0.039261844,0.048281714,-0.005007834,0.0053202305,0.008994056,0.06928269,0.029753277,0.02522648,0.015997209,0.04018841,0.04593141,0.01047294,-0.027140906,0.004878408,-0.05767185,-0.02723132,-0.015980305,-0.01275632,0.025247803,-0.0082056755,-0.030430716,-0.081227794,0.024793781,0.05236866,-0.11217092,0.041003913,0.053492732,-0.023542259,-0.011149701,-0.019687666,0.06585312,-0.031231988,-0.09443798,-0.028285109,0.029142616,-0.06272525,-0.08775799,0.0007723655,0.018269204,-0.0065514273,0.042234235,0.00958083,-0.046598684,-0.06350693,-0.015076792,-0.026599076,0.020461198,-0.038014095,0.050021686,0.047771014,-0.0030481091,-0.018861607,-0.03694536,-0.08350982,0.03784175,-0.019750325,-0.007670451,0.053546328,-0.106459625,0.046604235,0.01775414,0.1204076,-0.007407401 +1.2.1.106,"The enzyme participates in an L-arginine biosynthesis pathway in certain species of archaea and bacteria. In some organisms the enzyme is bifunctional and also catalyses the activity of EC 1.2.1.103, [amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase.",384,1.0,-0.03924786,-0.077031456,-0.12292477,-0.020699367,0.081580974,0.075710766,-0.018055048,0.009127714,0.03567316,0.0061693974,-0.0032873617,-0.017815804,-0.045155425,-0.019616814,-0.05367286,0.042371787,-0.14192818,-0.05776617,-0.001253008,-0.06873992,0.081126735,0.0484884,-0.092539884,-0.02228869,0.020959754,-0.071531616,0.056244217,-0.07831765,-0.058007054,-0.06966211,0.02839707,-0.08800847,0.08884286,-0.046375006,0.037512656,0.13946538,-0.031762023,-0.10563808,0.06001058,-0.004920643,0.048875254,-0.020349883,0.008616549,-0.072152816,-0.023858398,0.024994994,0.06504856,0.035055764,0.01581337,-0.00657991,0.009748999,-0.026268704,-0.04219745,0.0061907344,-0.021063806,0.09016878,-0.107935406,-0.05510565,0.013803356,-0.031205507,0.043576077,0.03282699,0.03541025,0.012278273,-0.022981435,-0.08188712,0.069646776,-0.063426875,0.045203403,-0.048568126,-0.021504179,-0.081741884,-0.054584358,0.0149017265,0.0037028242,-0.0008380849,0.009861947,-0.021611324,0.04488122,-0.05327363,0.011210071,-0.044923294,0.0013669428,0.03556037,0.03285291,-0.055328563,0.014034492,0.014162225,0.048810974,0.005179711,0.08015774,-0.07846171,0.046922434,-0.03393199,-0.04497843,-0.0011873858,0.0072280876,0.030498056,-0.0030663512,-0.029173544,9.362922e-05,0.09258638,-0.039483864,-0.07623496,-0.016080305,-0.02642743,-0.008625164,0.12953258,0.0074936175,-0.026158296,0.0050899806,-0.016252888,0.045233227,0.029209828,-0.03379793,0.09245312,0.049829133,-0.103888966,-0.122868955,0.022136359,-0.01406937,0.016382467,0.07095127,0.070957884,-0.051396817,0.030127363,-0.1070645,6.1688773e-34,0.017707124,-0.0020465904,0.0047931895,-0.04463848,0.055757705,0.02842892,-0.11143774,-0.00028064338,0.039211154,-0.04019149,-0.08987693,-0.04314525,0.08136972,0.03503223,-0.023140261,0.0207293,-0.012796016,0.0028969066,0.012789091,0.05252443,-0.062115896,0.04202577,-0.022199864,0.022896811,0.038617045,0.009688645,0.047619976,-0.019079912,0.001819658,0.015082963,-0.020486495,-0.10641288,-0.09601041,0.0015541217,0.07163495,-0.043001484,-0.011637536,-0.00952973,-0.0051153675,0.023421163,-0.022191383,0.05284831,-0.051510464,-0.0020396353,0.03609446,-0.047491167,-0.022594564,0.10371563,0.058073245,0.07952071,0.00082539103,-0.0578501,0.13066241,-0.038050253,-0.02779368,-0.0038718372,-0.061450377,0.010700043,0.07891982,0.04914427,0.021461211,0.06851344,-0.0023942173,0.078375906,-0.028928172,0.023380132,-0.006506459,-0.060225114,-0.0036098447,0.07805032,-0.07386379,-0.028335873,0.09658292,-0.017490674,-0.0053434437,-0.061292447,-0.08005706,-0.03174114,-0.013994674,0.018717002,0.0038224694,-0.04083419,0.07100726,0.028619274,-0.005825439,-0.03460698,-0.0195076,-0.042475414,0.032871246,0.013461384,0.0684824,-0.024683006,-0.09396738,0.03875847,0.031419303,-2.275712e-33,0.104038954,-0.12099737,0.0076541007,-0.11914552,-0.04627903,0.055263337,0.05744424,0.0062773633,0.024208605,-0.004608846,0.04566507,0.054742943,0.013790949,-0.038288727,0.0529342,-0.064951256,0.0502284,0.063047096,0.04022248,0.00848929,-0.010603892,-0.030815413,-0.0040301923,0.0063188197,0.027528994,0.007609774,-0.053795557,0.0603459,0.0009060604,-0.0046784724,-0.0092432955,-0.014911347,-0.019303052,-0.048265755,-0.048211847,0.06483301,-0.0025843824,0.025058968,-0.0071201576,-0.019308427,0.061804507,0.029922206,0.016285516,0.022777734,0.048917763,0.010750573,-0.012308665,0.02804213,-0.06661249,-0.10282737,0.05618388,-0.05244541,0.0752076,0.007572158,0.0139133725,0.006408147,-0.02416723,0.05927432,-0.017705997,0.05373326,-0.024370722,-0.07626526,0.03400501,0.012048079,0.010093658,-0.008008303,-0.03054229,0.080932535,-0.017287152,0.021211753,0.09556741,-0.013354569,0.03673083,0.10671047,-0.037666433,-0.024078738,-0.04993224,-0.0699719,0.056556754,-0.053133216,0.0014871506,-0.02364985,0.0013203812,-0.024832234,-0.06034272,-0.07832264,0.053764343,0.12009418,0.015557215,0.030290615,-0.038811084,-0.06443691,-0.07160232,0.015998935,0.057358913,-3.5043545e-08,0.046167925,-0.0026555147,0.048773125,-0.02867775,0.019131593,0.037552577,0.021721555,0.024893794,0.030692147,-0.028075725,0.033037927,0.028880889,0.020628076,-0.031280626,0.030446831,0.101867065,-0.057887178,0.070697546,-0.016381174,0.059752326,0.0024623405,0.0032419397,-0.11159792,-0.0011752362,0.036097284,-0.06227604,0.04215379,0.04110308,-0.031265143,-0.054901876,0.009003114,-0.00033444227,0.0045816014,0.00029532614,-0.0801998,0.016631488,-0.044819355,-0.057656515,0.00529458,0.0012558321,-0.067512035,0.05454148,-0.040741794,-0.008433204,0.007696162,0.08498822,0.005294114,-0.006923791,-0.035000894,-0.005064931,0.021320002,-0.050649412,0.048130658,-0.08461223,-0.10118074,-0.046965465,-0.050254468,-0.089296155,0.03606123,-0.023098763,0.06072425,0.0777937,0.13684073,-0.013336723 +1.3.8.17,"This enzyme is involved in the biosynthesis of factor 420 (coenzyme F420), a redox-active compound found in all methanogenic archaea, as well as some eubacteria. In some eubacteria the enzyme is multifunctional, also catalysing the activities of EC 6.3.2.31, coenzyme F420-0:L-glutamate ligase, and EC 6.3.2.34, coenzyme F420-1:gamma-L-glutamate ligase.",384,1.0,-0.0011766148,-0.00977931,-0.031909414,-0.018230768,0.04096699,0.032076005,-0.091114074,0.04179284,-0.03009927,-0.0059879753,0.020585513,-0.07888348,-0.011682605,0.05085756,-0.02196008,0.024760727,-0.044642188,-0.016899133,-0.10398508,-0.06779133,0.053128447,0.05063443,-0.0558541,-0.054165382,-0.0047499486,0.01853457,0.07045281,-0.047747172,0.011629437,-0.05908014,-0.012987433,-0.028891439,0.07821248,-0.032071188,0.027245132,0.05228954,-0.056646835,-0.12272595,0.060426023,0.015408815,0.019734712,0.043225028,0.059216093,-0.014358646,0.019680005,0.040958658,0.054278135,0.0038645815,0.025853995,-0.05873399,0.016323771,0.014970679,-0.03474253,0.033767648,0.0680281,0.021072961,0.020082993,-0.09311005,-0.030470693,0.0065556746,0.050917294,-0.006915011,0.0027129462,-0.03802141,-0.021712061,-0.006457596,0.08675645,-0.07334944,0.018898275,-0.05767232,-0.062081676,-0.064676955,0.009480112,0.029368749,-0.018757991,0.015170566,0.0074200146,-0.074470796,0.030912204,0.021781439,0.051398426,-0.034425534,0.07064579,0.016264617,0.05973723,-0.07705846,0.012318779,-0.044486076,0.04489002,0.02935205,-0.024637204,-0.027772857,-0.012533544,-0.01205453,-0.14131701,0.039618827,0.014791602,-0.0036185656,0.033085022,-0.021134598,-0.020178404,0.071928255,-0.016182153,-0.04076843,-0.060852416,-0.031872395,0.03878753,0.15732363,0.025225347,-0.00036918308,0.015584518,-0.04312536,0.044410806,-0.010788924,0.020914925,0.03924987,0.0324841,-0.09075409,-0.016459962,0.043905426,0.03289011,0.00706643,0.07798696,0.021697192,-0.027697386,0.034049757,-0.16425656,3.370624e-33,0.08793533,0.044178944,-0.04877452,0.00874268,0.044876713,0.0051235515,-0.08664648,0.063202724,-0.046330508,-0.031114653,-0.10820377,-0.06688586,0.06368631,-0.023616044,-0.061745986,-0.007910095,-0.030941986,-0.050856516,0.02768797,0.052054577,-0.01874593,0.053254418,0.0018228735,-0.0077557233,0.08979483,0.023290953,0.005656344,0.022492744,0.07024892,0.020976594,-0.045458443,-0.08356418,-0.15689625,-0.045683328,0.045565702,0.0022975018,-0.07018117,-0.04094081,-0.03375857,0.040112264,0.04795401,0.058700856,-0.060160432,-0.038688716,0.07224592,-0.01699317,-0.041533504,0.12816085,0.068862855,0.118574336,0.011384612,-0.0053246757,0.08990078,-0.029752428,-0.052309234,-0.030359773,-0.05792429,-0.0174454,0.034445886,0.05238763,0.02238698,0.048814185,-0.047998216,0.10106015,0.025474757,0.06223695,0.019468237,-0.016344426,0.0061180224,0.05211723,-0.045817714,0.002664455,0.078939095,-0.010523736,0.007106453,-0.07144492,0.0005830094,-0.07158373,0.07089666,-0.012274606,-0.012535818,0.00019435165,-0.01364418,0.0041384837,-0.0028488827,-0.014313303,-0.03779211,0.008457117,0.068862006,0.04069734,0.09172075,-0.07587387,0.032667797,0.016257897,0.006117134,-3.0485935e-33,0.055308383,-0.09387424,-0.015213384,-0.08124677,0.01237557,0.017473945,-0.00029761068,-0.03172098,0.010818687,-0.015086229,0.1560118,-0.012498909,0.057283755,-0.0071271984,0.0043601817,-0.014242784,-0.028787889,0.0627204,-0.0047771423,0.027599435,0.025962194,0.022158448,0.036644984,-0.013937468,0.0580754,0.037793178,-0.005469169,0.0004115952,0.009456624,0.044629835,-0.050412662,0.020030892,-0.0076944907,-0.06429182,-0.12136784,0.033374514,-0.0052505434,0.0023309398,0.015535197,-0.06926972,0.033872873,0.09864557,-0.016096912,0.02476817,-0.00166356,0.068954356,-0.011589259,-0.011611042,0.052004326,-0.053109225,0.020150594,-0.081359945,-0.034330446,-0.05261564,-0.082800716,0.019997265,0.029371388,0.030083561,-0.0011373506,0.014450472,-0.02441493,-0.07250817,0.09175104,0.016025793,0.09129846,0.049329486,-0.015622279,0.06391338,0.015010634,0.006721958,0.04073158,-0.0028441602,0.0020679664,0.11077998,0.0057850163,0.0097381305,-0.04242717,-0.026052237,-0.018249175,0.033828914,0.049068175,-0.036134128,-0.003837711,-0.028941201,-0.084433965,-0.14806412,-0.008458478,0.08213324,0.019669363,0.0012811393,-0.090604864,-3.570947e-05,-0.026379101,0.055800118,0.06433492,-3.74853e-08,0.01977485,-0.018617809,-0.028707819,-0.054370236,0.038991615,0.06668144,-0.013318021,-0.010123516,0.057412244,-0.023657732,0.022181382,0.0949022,-0.033574,0.0035462424,0.018947965,0.0074545047,-0.043232262,-0.013093989,-0.02224646,0.0058477037,-0.039039012,-0.007268966,-0.04815881,0.032919664,0.01714995,-0.0978696,0.025226183,0.08856308,0.00492562,-0.110955335,-0.05992744,0.038328476,-0.0122324545,-0.017955333,-0.15746889,0.012696308,0.014643824,-0.0113810245,-0.07522711,0.04928505,0.018497407,-0.057958815,-0.109601386,-0.005581609,0.04145815,0.024387699,0.030700728,-0.014954081,-0.033069305,-0.036325205,-0.00842067,-0.012802966,0.044983942,0.019901397,-0.0918131,0.018520381,-0.016898049,-0.051642645,-0.016989326,-0.041263897,0.0470938,0.0064348746,0.16922894,-0.07818488 +1.3.98.7,"This is a bifunctional radical AdoMet (radical SAM) enzyme that catalyses the first two steps in the biosynthesis of the enzyme cofactor mycofactocin. Activity requires the presence of the MftB chaperone. The other activity of the enzyme is EC 4.1.99.26, 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase.",384,0.99999994,-0.06438816,-0.085241094,-0.15061592,0.02409043,0.098690644,-0.008094667,0.03332941,0.05491876,-0.023773268,0.020816186,0.04931266,-0.011946857,-0.028755378,0.10370373,-0.062276185,0.114397176,-0.036681887,0.024557475,0.023516603,-0.037748408,0.0042262967,0.03710356,0.006078828,-0.027209144,0.038234685,-0.0039692298,0.03358885,-0.036513444,-0.023411473,-0.06305302,0.04462101,0.00079553074,0.052048046,0.0005343613,0.056352194,0.0523833,-0.0067134886,-0.09755723,0.046067633,0.0222471,0.04094483,0.008640791,0.05794515,-0.066735685,0.016137525,-0.023719426,-0.026271295,0.0016140231,0.044274762,0.058454495,-0.023433069,0.0057155546,-0.06982446,0.027887229,0.0048691975,0.009931485,-0.06468014,-0.067417234,-0.013689934,0.044331655,0.060398217,-0.015110755,-0.029606894,-0.008838359,0.004098885,-0.0029672284,-0.0516203,-0.07893209,0.07236451,-0.0700173,-0.055905588,-0.056266014,-0.03343785,0.041567497,0.037106887,-0.011245236,-0.04108466,-0.036212187,0.049119506,0.020416869,0.011935845,-0.0055197785,-0.0040789023,-0.027552787,0.087231815,0.007913024,0.12401083,-0.020506635,-0.008974386,0.06931343,0.02693832,-0.0426541,-0.03964504,-0.09038405,0.010211352,-0.0028973536,0.017240481,0.048806876,-0.050305583,-0.02496509,-0.006549755,0.048702575,-0.0007196138,-0.0667764,-0.03369219,0.014238879,-0.053817257,0.11921497,0.10196535,0.053284865,-0.03965644,-0.020501392,0.0053611672,-0.00017228705,0.01283698,0.1471022,0.03603726,-0.048168734,-0.043844644,0.046633296,0.055653337,-3.6543654e-05,0.001508682,0.023977038,-0.11086765,0.019859998,-0.10221977,1.273014e-33,0.084247634,0.04735304,0.032142304,-0.0052184383,-0.02343192,-0.033434734,-0.14684597,-0.007683221,-0.00152036,-0.04283618,-0.008072681,-0.00797718,0.052430965,0.062716775,-0.11201096,-0.098565266,-0.004468059,-0.057150792,0.07397724,0.0011936749,-0.046104815,0.06773811,-0.08638613,0.00159574,0.0091513,0.03476984,-0.011985691,0.05621112,0.054036647,0.043181576,-0.01764236,-0.017734068,-0.13179684,-0.013788029,0.012902337,-0.015353877,-0.004291907,-0.14634123,0.034420554,-0.0064274524,0.0045363735,-0.06259563,0.038354833,-0.03438829,0.0194027,-0.08472981,0.036752652,0.06395658,0.029203277,0.034772754,-0.0002641104,-0.04608062,0.059629094,0.0015102233,-0.033713657,-0.029168122,-0.033703413,-0.020665681,0.054393135,0.06355285,-0.021420458,-0.012774832,-0.09978168,0.12038772,-0.06672574,-0.08644587,-0.0733674,-0.057010166,0.005118351,0.079061046,0.013602279,-0.019028459,0.066060215,0.012873061,0.0532611,-0.022926576,0.013191471,0.04390453,-0.04666596,-0.025326189,-0.028654175,0.06478254,-0.01711703,0.031742737,-0.012973392,0.0016206146,-0.039349675,-0.028785663,-0.03808743,-0.04659399,-0.052578762,-0.031715356,-0.012206362,0.09215778,0.0056981323,-2.7252316e-33,0.089965366,-0.13207121,0.039578903,-0.08452755,-0.075305544,0.014889515,0.091272034,0.03313189,0.05920112,-0.03449386,0.04285029,-0.053619046,0.07625453,-0.11262444,0.059529852,0.0074935835,0.008261271,0.02036554,0.022139592,0.05092668,-0.0038518931,0.06633759,0.03616992,-0.03695971,0.031159695,-0.024451029,0.039899096,0.02914839,0.03864066,0.07761695,-0.047081426,-0.061742485,-0.054098815,-0.05552631,-0.08560326,0.03318132,-0.029899314,-0.036231272,-0.033346366,-0.054527927,0.007615976,0.035755474,-0.023330731,0.06440099,0.024728375,0.01816318,-0.04287311,0.04423237,0.03413593,-0.07770436,-0.04873995,0.001468579,0.015487191,-0.0077967257,0.004461614,0.057135098,0.0807182,-0.01835797,-0.015795456,0.0041577695,-0.04980255,0.054363884,0.0563119,-0.03893573,0.06809196,0.053083234,0.016055267,0.03514364,0.029027212,-0.014008652,0.11594586,-0.0047758813,-0.036853716,0.07216879,0.015655745,-0.08027842,-0.05824197,0.023384253,0.019296758,0.01856273,0.046423964,-0.03551772,-0.024549538,-0.10126338,-0.024579851,-0.05676478,0.032793373,0.16009009,0.0143802855,0.0058018626,-0.006571893,0.029264405,-0.074604176,0.062011518,0.00393933,-4.1171347e-08,-0.008565987,-0.03922041,0.09784199,-0.053769983,0.037487794,0.03662959,0.04815263,-0.022669649,-0.039315693,-0.024534542,0.032183442,0.06238451,-0.007191406,-0.034873575,0.03514471,0.0135456845,-0.025604632,0.017581744,0.018859455,-0.022322929,-0.018481342,-0.028676905,0.017024038,0.04386665,-0.057775877,0.0032272025,0.07725138,0.100167766,-0.028096803,0.022370556,-0.020383468,0.036514863,-0.01591187,-0.053008612,-0.17898619,0.020773089,-0.0072811274,-0.025701297,-0.019063001,0.036853544,0.04853966,-0.02162849,-0.0057673543,0.016465222,-0.044222865,0.023981905,0.014379076,-0.04426179,0.025689645,0.047257584,0.023824489,-0.01759503,-0.04143642,-0.009598292,-0.031539157,0.007828091,-0.008836992,-0.06641814,-0.0010317907,-0.032419834,0.037897825,0.0508862,0.101180345,0.0017619045 +1.5.1.54,"A flavoprotein (FAD). The enzyme, found in plants and some bacteria, catalyses the reversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADH as the electron donor. It play an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. These proteins either contain a C-terminal domain that does not mediate allosteric regulation (as in plants) or lack this domain entirely (as in Escherichia coli). As a result, the plant enzymes are not inhibited by S-adenosyl-L-methionine, unlike other eukaryotic enzymes, and catalyse a reversible reaction. cf. EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).",384,1.0,-0.0454216,-0.048912615,-0.12658916,-0.004805959,0.12991561,0.09724153,-0.12607816,0.043007217,0.06599823,0.006968994,0.017545918,0.005047224,-0.06505259,-0.041975692,-0.074705735,0.020850193,-0.08518586,0.024687357,-0.050104544,-0.0061745765,0.026821684,0.035305694,-0.018544264,-0.0071729273,0.02623773,-0.035057425,-0.05225826,-0.056767434,-0.073211685,-0.06280351,-0.011167398,0.01873189,0.072466075,0.034176163,-0.02634739,0.108033195,0.045216702,-0.072041936,0.053749483,0.014023255,-0.009214095,-0.037796732,0.040944744,-0.05180753,0.009598265,0.007855777,0.0146482615,0.04221131,-0.00018532143,-0.011003556,-0.018266883,-0.022750486,-0.053072844,-0.0023665298,0.010594385,0.025190322,0.090577684,0.0041534975,0.004686187,-0.014528705,-0.007865286,-0.08233822,0.012600607,-0.0043628532,0.033766545,-0.0896615,-0.053462584,-0.08006798,0.049681228,-0.015148969,-0.015514188,-0.04369106,0.0091586085,0.036695126,-0.010593756,0.0764897,-0.06555483,0.022645527,0.03350052,0.02983338,0.0786544,0.0048057213,0.040029507,0.027256506,0.06964151,-0.02571219,-0.06425406,0.04700923,0.023390103,0.058827717,0.004272165,-0.0028193428,-0.0012476742,0.013347183,-0.106432706,0.04471077,0.10372326,-0.077887304,-0.022823464,-0.06699381,-0.030569896,0.0187367,-0.0073849456,-0.003991393,-0.056502964,-0.015258037,-0.056785647,0.07030722,-0.0722206,-0.027145052,-0.018630031,0.010696547,0.018147279,-0.030729828,-0.026831055,0.019967303,0.0059017283,-0.1219036,-0.06454883,-0.008244947,-0.061013162,0.03093004,0.07788129,0.08924572,0.036719833,-0.03226179,-0.11545582,5.7151206e-33,0.081282824,0.058554865,-0.07009608,-0.016815066,0.037148416,-0.024663044,-0.010375733,0.057729967,0.044017658,-0.060968146,-0.041549996,-0.008905658,0.07905513,-0.059521444,-0.014405856,0.013360441,-0.023745077,-0.08614816,0.05595173,-0.07349584,0.027287234,-0.03876485,-0.032970186,0.048280105,0.039130725,-0.0106539475,-0.014942256,0.025448551,0.016573783,0.0043434277,-0.011233074,-0.06575155,-0.061121177,0.02591558,0.06936159,0.02639385,-0.07840096,-0.048609834,-0.04596461,0.10607849,0.004827327,0.012701508,-0.0054541645,-0.029488683,0.07554667,-0.016020326,-0.08352219,0.08308336,0.00017628093,0.104618005,0.070208035,-0.03256144,0.098386355,0.009197025,-0.052307952,-0.016773565,-0.025187194,-0.058298476,-0.0731067,0.05682624,-0.011514498,-0.00067539647,-0.026168985,0.052892663,-0.06613772,0.022797838,-0.0736969,-0.05150713,0.022386441,0.12318962,0.036283202,-0.04836293,0.09637157,0.02472296,0.046884455,0.0017077327,-0.0416805,-0.013413783,-0.0028603384,0.052895606,0.03742792,-0.00065721344,-0.04129325,-0.026690878,-0.029861446,0.000681172,-0.02668108,-0.06935704,0.008717432,-0.008583267,0.09862792,-0.087449946,0.019733004,-0.016094347,0.041351575,-5.2833938e-33,0.0857358,-0.060137883,0.035578787,-0.039421186,-0.010174848,0.061180145,0.016401606,-0.07965924,0.03301996,-0.088279985,0.02244897,-0.005225478,0.0041816263,0.01724552,0.010935012,-0.0072999736,0.0021525342,0.04516539,0.014442487,0.033942115,-0.0517659,0.0041456553,-0.0039011,0.06872251,0.0445208,-0.008573544,-0.068084165,0.020476252,0.03462761,0.032255873,0.010350818,-0.010088078,-0.07235666,-0.023331704,-0.022258664,0.07802313,-0.106819,0.035113655,0.028387368,0.08116179,0.020127902,0.015689632,-0.017235454,0.010498407,0.0677382,0.057710335,-0.091355406,0.041915998,0.053083662,-0.030582273,0.04522938,0.014730003,-0.0119942445,0.057270452,0.043913323,0.034833115,0.061441183,0.06144154,-0.012386212,-0.02145391,0.0009011131,-0.094655,-0.0017226248,0.016327363,0.047132276,0.06646431,0.036602207,0.1249261,0.043027002,0.059100546,0.09992197,0.01325664,0.07722844,0.08080155,-0.019559162,0.0043183533,-0.033649903,0.02679644,-0.07183801,0.022860754,0.027321415,0.026376907,0.016086172,-0.007603592,-0.032867033,-0.05670579,0.005216072,0.03520903,0.008378509,0.03130181,-0.02947345,0.032800943,0.020551998,-0.018191237,0.13725302,-5.279793e-08,-0.0011529633,-0.063198335,-0.014366347,-0.047085285,0.05334598,0.02813334,0.015938783,-0.04829473,0.029141355,-0.037219457,-0.09987391,0.13169503,-0.022331554,0.0012828765,0.0424942,-0.03772713,0.0032925576,0.02852725,-0.0062401816,0.0327753,-0.11532753,0.015325028,-0.16556993,0.008127986,-0.016441157,-0.041833922,-0.0041522062,-0.044076625,0.09169599,0.004224644,0.07971799,0.021817336,0.056045346,-0.031866692,-0.13792,-0.006639968,0.026150044,-0.0647324,-0.04415204,0.03789463,0.0043294793,0.0188136,-0.04656713,-0.0007726584,-0.026722886,-0.010013748,0.02404966,0.018271059,-0.02451062,0.0064862035,0.021651847,0.0034116402,-0.0059643686,-0.054572318,-0.07156833,-0.0131684,-0.007972612,-0.051682327,0.009411405,-0.031843085,-0.04593374,-0.0026263585,0.1628557,-0.04055336 +1.14.14.177,"The enzyme, which is expressed in the epidermis of mammals, catalyses the omega-hydroxylation of ultra-long-chain fatty acids (C28 to C36). The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation.",384,1.0,-0.019413378,-0.016272072,-0.02051473,0.027486192,0.06570927,0.08020045,-0.050078407,0.049806964,-0.02513159,-0.011354748,0.03789423,-0.1268666,-0.0888462,-0.018776948,0.011222164,0.019520147,-0.052589703,0.026100807,-0.018433457,-0.082242824,0.04744085,-0.01968059,-0.018234959,-0.00027729222,-0.05439796,-0.05723141,0.03913856,-0.07074851,0.004416143,-0.060899682,0.026876122,-0.13202217,0.002038465,-0.03850623,-0.041068777,0.01185955,-0.075518005,-0.06075382,0.02814148,0.012775794,0.047750875,-0.028632266,-0.028238699,0.0052041532,0.0144204525,-0.10421439,0.027228072,0.030757768,0.011494796,0.058275986,-0.025287617,-0.07368362,-0.0660039,0.024336973,-0.07762781,-0.033144698,-0.09214586,-0.061256826,-0.017344223,0.034151,0.064030305,-0.033476867,0.024108108,0.04363233,-0.0051103025,-0.10133986,0.021183997,-0.034203455,-0.0523421,0.0100123165,-0.07104386,-0.10323089,0.04191429,0.06960171,0.044206556,-0.0069038067,-0.10561724,-0.024564473,0.05439389,-0.014689563,0.03187093,-0.0152545795,-0.050140858,0.112738885,0.092807,0.026146593,0.011173018,0.004175766,-0.015455331,-0.00043424813,0.035640847,-0.037831914,-0.023237456,0.012701087,-0.067236096,0.049374305,0.02929861,0.036041193,0.022425909,-0.015515188,-0.046467867,0.010627868,-0.05155548,-0.06928669,-0.07252453,-0.0073782774,-0.072866574,0.1002587,0.0028323324,0.02075809,-0.03490045,-0.0030174826,-0.04519521,0.022164952,0.003665583,0.031528812,0.028288882,-0.09073876,0.04647639,-0.06797429,0.0065197153,-0.0056747245,0.024070883,0.035975996,-0.006442316,0.020384701,0.0091924695,-1.7081274e-34,0.028399328,0.02579797,-0.031190224,-0.064880155,0.012681018,-0.0018730505,-0.05483169,0.0015181137,-0.09012124,0.035641283,-0.035465732,0.010670074,0.029530516,0.07531178,0.05542,-0.025230028,0.052396774,0.046371337,0.08522027,-0.09165171,0.01839908,0.05663997,0.0048502516,0.018761257,-0.03551525,0.050427016,-0.050191354,-0.0030926247,0.0693549,0.0110974675,-0.06315448,-0.059698228,-0.027687581,0.010397861,0.06684116,0.04677979,-0.011885106,-0.066342026,0.037850887,0.03588673,0.045557875,-0.056908377,0.053905148,-0.06872,0.012176078,-0.010402337,-0.042721566,0.08790854,0.042024877,0.03834298,0.07051661,0.0027876142,0.08851137,0.014746787,-0.038684573,0.040781107,-0.07703371,0.030608213,-0.06723448,0.03990964,-0.0038028867,0.03441425,-0.004739072,0.0703741,-0.041784808,-0.022949755,-0.051016405,0.0020956735,-0.031912193,0.053978637,-0.026916504,0.013978193,0.15540268,0.0059678517,0.070135586,-0.009870689,-0.07524056,0.09983329,-0.023429204,0.019636793,-0.03038485,0.06421953,0.009388957,0.0010057989,0.0067303246,0.008462422,-0.021979807,0.04135241,0.029159127,0.024941381,-0.016279645,-0.036344677,-0.007772947,0.0555697,-0.045479827,-2.1965807e-33,0.082131915,-0.08952594,0.097186044,-0.119010404,-0.012843192,-0.0005164021,0.020015713,0.044098023,0.0010241657,-0.028202362,0.092483334,-0.0007032931,0.020684853,-0.0608764,0.013150018,0.009798343,0.0039143525,0.064244986,-0.0059261657,-0.127552,0.011021714,-0.0051783407,-0.010501879,0.11590761,0.04772712,0.010796676,0.045192376,0.03517637,0.052382603,0.054532796,-0.040020026,-0.00937526,0.0007180443,-0.04443737,-0.029826574,0.032102603,-0.05525411,0.013561132,0.0048684743,0.048269328,0.028949939,-0.07751341,-0.0070889434,0.034935568,0.09241221,0.07318689,-0.07156564,0.019117517,0.004103458,-0.07167801,0.064644486,-0.0016769782,0.055863768,-0.037876036,0.058296707,0.09844956,-0.019346433,-0.035542823,0.075517125,-0.05422742,-0.0056116944,-0.058361277,0.020585455,-0.008969193,0.013089445,0.0010825101,-0.085951805,-0.03729435,-0.030776361,0.027705628,0.070586294,0.051345278,-0.07975375,0.035953812,-0.02471861,-0.04108392,0.0058812383,-0.10937831,-0.046254862,0.040263414,-0.0024679962,-0.0037681728,0.0093720155,-0.041293815,0.014430574,-0.045639373,-0.049133014,0.03251811,-0.0007366716,0.02056741,-0.05516775,0.023012618,-0.05335474,0.020762913,0.04215659,-3.733397e-08,0.07936482,-0.02504907,0.03766632,-0.08394599,-0.060311757,0.10531632,-0.021290641,-0.053971056,0.06196268,-0.06250055,-0.06083666,0.07100035,0.075994775,0.093443505,-0.019771172,-0.007840909,0.023631401,0.01554948,-0.015475287,-0.061190296,-0.09177169,-0.0018881165,0.010066101,0.026563173,-0.010797414,-0.023028806,0.040742055,0.06432424,-0.052965928,0.06837051,-0.04185001,-0.002204606,0.01999755,0.055525873,0.045542575,0.056809846,0.018540297,-0.061720002,-0.04219554,0.10595801,0.015540648,-0.0070202583,-0.087674186,0.015072502,0.03926094,-0.013061822,-0.032296676,0.07055629,-0.009388818,0.015827429,0.017477516,-0.039393052,-0.06497783,-0.070996724,-0.07153719,-0.05112519,-0.04380188,-0.06626903,-0.057280805,-0.04237586,0.05048999,0.02290873,0.22965671,0.037427995 +1.14.15.39,"This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.",384,1.0,-0.03413857,-0.025273517,-0.068939656,0.026127797,0.074026704,0.04643176,-0.08863379,-0.00892198,0.05192777,-0.043773986,0.028402448,-0.056299496,-0.002897114,0.036771096,-0.07023359,0.023356711,-0.07666787,-0.030019928,0.012764253,-0.023869721,0.004613162,0.03220836,0.078970626,0.018180829,0.041232493,0.03712776,-0.022925096,0.05174016,-0.0047169235,-0.08128356,0.07965689,-0.020082723,0.089094855,-0.033807162,-0.005010268,0.11712918,-0.027615275,-0.10998539,0.073835,0.053162567,-0.03575671,0.011282843,-0.011877224,0.012853326,-0.044333883,-0.020453207,0.059749782,0.053728577,0.07999927,-0.04882125,0.018287586,-0.048906244,-0.10233271,-0.008578754,0.017843451,0.050011043,0.044491943,-0.06890056,-0.05896513,-0.065533094,0.06601786,0.02655741,-0.0005595675,0.032350168,-0.100906365,0.041899763,0.02312051,-0.08609527,0.023530722,-0.022089273,-0.14993975,-0.058268584,-0.025192427,0.055058017,-0.04885006,0.058553956,0.019305637,-0.03364847,-0.026127385,-0.019875575,-0.0013488301,-0.053777516,-0.042501796,0.102450155,0.055539403,-0.021811118,-0.021848017,-0.03331376,0.07642491,0.01924603,0.042342175,0.055353772,-0.009635033,-0.016443828,-0.061366893,0.061765034,-0.052302208,0.03697065,-0.055053852,-0.013716411,-0.045486547,0.032150462,-0.02844783,-0.068771884,-0.003309962,-0.015092939,-0.015428149,0.039986726,0.036278874,-0.084632084,-0.055531584,-0.059017196,-0.005697274,-0.01656388,0.021510063,0.046566863,0.056827046,-0.08405668,-0.017946864,0.01541389,-0.031281665,-0.012321643,0.001226419,-0.0046867155,-0.02458559,-0.010876582,-0.056092124,3.735476e-33,0.03206419,0.059982475,0.02612173,0.04940932,0.022640798,0.050117638,-0.059893202,0.040362768,-0.05566141,-0.069916554,-0.14523971,-0.03324566,0.048815094,0.022238376,0.06340442,-0.017112892,-0.039285533,0.026408369,0.0735989,-0.0337843,0.0136705,-0.032887623,-0.047643296,-0.067940146,0.0140994415,0.056950007,0.031257153,0.0034588315,0.07948334,-0.015231097,-0.0016889214,-0.025613487,-0.10276113,-0.086840995,0.0026244125,0.0020611058,-0.016799925,0.00468058,-0.037774943,0.07590268,-0.034863744,0.029123452,0.019633107,-0.023608766,0.094148226,-0.067302056,-0.08947573,0.11131271,0.12371618,0.019577038,0.067290835,-0.04316443,0.08011911,0.022007577,-0.07969299,0.09106951,0.0079544345,0.027549207,0.046595693,0.008832109,0.056350876,0.047368634,-0.0022419665,0.01258478,0.057725858,0.07117236,0.029566826,-0.025187626,-0.02752079,0.08186372,-0.06376924,-0.009731138,0.042173218,0.052346833,0.0038005966,0.0032940805,-0.096775055,-0.026229555,0.11705848,0.013766186,-0.08139197,-0.03680307,0.05417184,-0.036309265,0.017349994,0.0070442604,-0.014115841,0.03433753,0.08668733,0.13140346,0.062147815,-0.079811975,-0.008379629,-0.023388108,0.032811224,-3.8484774e-33,0.08926901,-0.11871183,-0.029024804,-0.088325284,-0.050075747,0.0361165,-0.04940846,0.0314185,0.010616088,0.039163515,0.072001144,-0.01915221,0.06328936,-0.05078342,0.029402789,-0.05795349,-0.03547002,0.04178959,0.0053157704,0.051558346,0.1041278,0.010828446,0.04840797,0.02436258,-0.006378844,0.0515222,0.07027459,0.005657079,0.026325906,0.026305817,-0.012510736,-0.03710569,-0.02267924,-0.038935065,-0.03808092,0.065879524,-0.08548936,0.0023759713,0.041517116,0.01708348,-0.004100012,0.05800912,-0.034771174,0.015368294,0.02830946,0.07698879,-0.097201325,-0.03775424,0.012089834,-0.092957035,0.018616872,0.039558694,-0.04503221,0.014384093,0.008601085,0.00066660694,-0.025513273,-0.019629385,0.023612898,-0.05806155,-0.013054886,-0.026935136,0.01289747,-0.027390437,0.061444588,0.049709797,-0.010190526,0.07635774,0.018710727,-0.023322646,-0.00076348643,-0.04936045,0.005309817,0.041281145,-0.025285196,0.051177192,-0.034574628,-0.023322107,0.024362786,0.029453678,0.03596532,-0.026895601,-0.030676143,-0.020749653,-0.09155906,-0.14012635,0.0038536678,0.07574651,0.04049434,0.022957705,-0.017656175,0.034931816,0.011180251,0.030132443,0.09764358,-3.8743455e-08,-0.031340342,0.054450274,0.11537697,0.03537304,-0.012282627,0.007531043,-0.022905363,-0.044715397,0.06048571,-0.10959518,0.025748642,0.009827488,0.061491687,-0.0117334835,0.010891822,-0.0045288946,-0.015147725,-0.015902495,0.039444212,0.01072664,-0.08893787,0.01982383,-0.00035284055,-0.032451287,0.08842045,-0.08132165,0.03060149,0.0059314864,0.0015307214,0.016153863,-0.011247646,-0.005473385,-0.030449541,0.060550954,-0.08055344,0.0031153515,-0.052344862,-0.070822276,-0.034023177,0.03168048,-0.013066282,-0.09245443,-0.093971595,-0.03283339,0.025388513,0.03016834,0.028207041,-0.033353955,-0.050954234,-0.027417142,0.054594032,-0.023768399,0.034838427,-0.0014316814,-0.080881104,0.043540467,-0.041968662,-0.064636625,-0.0657376,-0.06688035,-0.02779185,-0.041796878,0.112993315,0.013120823 +1.14.19.78,"The enzyme, characterized from the bacterium Teredinibacter turnerae, is specific for decanoyl-[acyl-carrier protein]. Activity is maximal when decanoate is loaded onto a dedicated acyl-carrier protein (TtuC), which is encoded by a gene in the same operon.",384,1.0,-0.09670589,-0.06968081,-0.06722301,-0.026760032,-0.048157588,0.0060033803,0.0012632781,0.07139045,0.017061941,-0.013365675,0.043818414,-0.025382109,-0.09121575,0.14725532,-0.016077505,0.036811974,-0.010737831,0.009298287,0.017823702,-0.04976051,0.015916921,0.060017355,-0.04005879,-0.011353203,0.030407012,-0.014692387,-0.008215805,-0.0045778053,0.053174462,-0.05814326,-0.020154886,-0.033838615,0.04169936,0.030598883,0.077827476,0.05261131,-0.094868444,-0.057311412,0.10303264,0.0005503476,0.063545525,-0.014786091,-0.021170486,0.048623346,-0.02025779,-0.02570576,-0.031032557,0.06698653,0.029441316,-0.038970422,0.045275662,0.023688817,-0.0579108,0.07696762,-0.0843598,0.0398047,-0.0070356913,-0.05789391,-0.02691622,-0.031463835,0.009942854,0.061419,-0.023149388,0.027187832,0.056290675,0.00029256693,-0.011796953,0.00061108696,0.091512255,-0.043206338,0.005704911,-0.07254372,-0.011799215,0.08357166,-0.022064807,-0.0051345136,0.017105209,0.024873663,-0.026164664,-0.056174427,0.03866698,-0.053347893,0.05138886,0.051972542,0.06444974,-0.05046444,-0.012331021,0.0172853,0.054583445,0.072988555,0.031170107,0.0011452925,0.0025143854,-0.07192113,-0.09277385,0.0465681,0.013171393,-0.021056648,-0.028229192,-0.0027914282,-0.041983142,0.06021264,-0.012974991,-0.048170816,-0.09639902,-0.04472749,-0.017787814,0.026257478,0.013715442,-0.05380453,-0.057721373,0.021975355,0.05311808,0.024731996,-0.02380759,0.040042147,-0.030397445,-0.010605696,0.0061236955,-0.016036471,-0.055627692,-0.035292782,0.023254272,0.054271188,-0.031412758,0.034078177,-0.11129715,-5.318263e-34,0.068533756,0.0071507986,-0.03529789,-0.012226355,0.013974286,-0.027662544,-0.07646984,0.05326064,-0.053722274,0.012423601,-0.070338756,-0.07823366,0.04354437,0.050433032,0.058714468,-0.0039039997,-0.04424592,0.040239334,0.051786534,0.0063645192,0.032072708,0.116945505,-0.009342445,-0.011854611,0.03927635,0.007129871,-0.06440975,0.014291112,-0.03781696,0.01639911,-0.024311462,-0.12249336,-0.025850123,0.047556527,0.1586697,0.014541253,-0.029824745,-0.027480692,-0.0028815349,0.061964456,-0.004930525,0.022331292,-0.038212594,-0.026357636,0.002643677,-0.044730846,-0.04441563,0.032903872,-0.058537796,0.030874858,0.05962608,-0.024158886,0.020636966,-0.07912381,-0.020772226,-0.004023709,0.017218843,0.0421602,0.07339237,-0.012162468,0.06789698,0.007986172,-0.070303164,0.019081734,0.010765036,0.008001945,-0.06952753,-0.022193274,0.021477256,0.103060685,-0.08575661,-0.02645767,0.08709274,-0.0423248,0.12091521,0.0041996287,-0.05201017,0.028371194,0.025980702,-0.007883968,-0.05194947,-0.051251356,-0.018862495,-0.045132145,-0.052700426,-0.029523874,0.0022920887,-0.03570352,-0.0057563423,0.00791343,0.10957916,0.016566308,-0.035001718,0.041592333,0.06825375,-9.911105e-34,0.07422552,-0.09934872,-0.01429845,-0.06402512,-0.07587458,0.022066407,-0.016111812,0.011943332,0.027742941,0.00033494245,0.15035424,0.016455794,-0.03929939,-0.02500185,0.025059512,0.031138195,0.023832101,0.06311525,-0.036903974,-0.032749105,-0.035175215,0.05354901,-0.059408907,2.1939692e-05,0.051089283,0.023939425,-0.06600714,0.13742247,0.041520774,0.020157607,-0.051877074,0.054465093,0.009974876,-0.018101694,-0.09635808,0.05216028,-0.005714876,0.009629241,0.030867333,0.008696416,0.10015033,0.028189953,-0.04958707,0.116026,0.0015068852,-0.015906535,-0.04896932,-0.058899537,0.053240594,-0.049955428,0.07942253,-0.04368738,0.0781819,-0.016442697,0.01666968,0.073735245,0.021592466,-0.05076179,-0.015689865,-0.021519082,0.03543658,-0.071110986,0.039255533,0.005401575,0.002199578,-0.016881723,-0.042560514,0.071967125,0.015723376,-0.04965174,0.0055089616,0.039626796,0.00081279746,0.04465459,-0.058351167,-0.10656928,-0.025310304,-0.04816661,-0.010322733,-0.050403792,-0.09910924,-0.020152379,-0.049888544,-0.08244078,0.010267846,0.025134606,-0.046657424,0.10221235,0.0086100865,0.015397726,-0.02552842,-0.014880609,-0.035723582,0.08477287,0.048108213,-3.465652e-08,-0.010827867,-0.05752583,0.008487304,-0.01974222,0.026692906,0.10150264,0.025121912,0.00074948353,0.028328698,-0.026827183,0.0075729038,0.087683305,-0.04835444,0.04194297,0.035920497,0.078703254,-0.066789046,-0.03822227,-0.03243255,-0.061579973,0.008823103,-0.014630007,-0.066887334,0.044423584,-0.025255013,-0.017345205,0.013577192,0.07571896,-0.01869635,-0.049485542,-0.023627322,0.0020904618,-0.045852616,0.0057427217,-0.023194369,0.0450877,0.0047838097,-0.09980448,-0.03659322,0.038996324,0.010558134,0.07091501,-0.13070457,0.058960985,0.077776216,0.022030588,0.06255622,0.046952266,-0.055444375,0.018236691,0.051670644,-0.016824808,-0.032989588,-0.023547355,-0.0801855,0.044602845,-0.046194278,-0.07038449,-0.08797325,-0.03364586,0.008165155,-0.0067747664,0.19813482,-0.09530738 +2.1.1.375,"The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses) catalyses two successive methylations. In higher eukaryotes the two methylations occur in the reverse order and are catalysed by two different enzymes (cf. EC 2.1.1.56, mRNA (guanine-N7)-methyltransferase, and EC 2.1.1.57, methyltransferase cap1) that do not required a specific motif.",384,0.99999994,-0.032434925,-0.012131341,-0.08439748,-0.02412842,-0.019375328,0.019222429,-0.047131937,0.022519022,0.056006044,-0.03313524,0.0354707,-0.022564674,-0.0146406805,0.050307445,-0.058065902,-0.0056056594,-0.14628461,-0.03556442,0.024742236,0.010690777,0.06866384,0.03927229,-0.05439589,-0.09143439,-0.008297885,0.033480585,-0.01111828,0.019102678,0.09477947,-0.05868358,0.017108418,-0.019420914,0.046361234,0.042978827,-0.0014287491,0.075587876,-0.018393327,-0.007238598,-0.042630635,0.044083465,0.032609735,0.1052408,0.015442977,-0.014417877,-0.0052837925,-0.012712759,-0.015199742,-0.025303736,0.02298725,-0.03151253,0.008330161,-0.058237366,-0.023185104,0.037387874,0.020816728,0.016768487,-0.058015943,-0.058329724,-0.01660256,0.042366873,0.071542606,0.032461256,-0.034907635,-0.055960074,0.0833223,-0.05369872,0.059455283,0.053239103,-0.00486973,0.054464176,-0.07211385,-0.05284026,-0.09717738,-0.015737897,-0.090381995,0.06671157,0.022931634,0.030717265,0.01062763,-0.041833483,-0.064628035,0.0005164608,0.10389574,0.013371371,-0.026035463,-0.021791944,-0.05375155,0.047582157,0.096315295,0.10904265,-0.01979208,0.028107466,0.06147038,-0.03054256,-0.012597457,0.04458344,0.047473453,0.0788306,0.08781883,0.018193658,0.035967283,0.007783347,-0.041982625,-0.020730928,0.04557688,-0.0124565475,0.00046795118,0.074581586,0.027123777,-0.008454038,-0.023795031,0.13372235,0.069917664,-0.037420176,-0.018219087,0.025234124,-0.0080616055,-0.020884603,-0.053993937,-0.020639166,-0.04886584,-0.044038687,0.033914555,-0.019065943,-0.020291338,0.03828213,-0.100570396,2.6037595e-33,0.024719672,-0.026891414,0.021251272,-0.043244716,0.04233602,0.0501506,-0.06080738,0.059098426,-0.051397033,-0.061499167,-0.025286887,-0.06768542,0.051335257,0.02661871,-0.036114216,-0.036165696,0.021335108,-0.00964296,-0.020433761,-0.013313169,0.042358942,0.0058965026,0.013680826,-0.097797886,3.6939193e-05,-0.012085104,0.007823696,-0.051128812,0.015625695,-0.06979866,-0.024847137,-0.05155445,-0.030055625,0.054450806,0.06030962,0.030213984,0.0017015329,-0.001351907,0.04047751,0.04879786,0.124796614,0.026962362,-0.035745822,-0.01516454,0.051599935,0.010465265,-0.030644054,0.03081851,-0.02822463,0.020031195,0.041465707,0.041651186,0.030926105,-0.045393348,-0.025843868,-0.030233134,-0.02933107,0.009419064,-0.03287253,0.0027340807,-0.008456948,-0.024100991,0.01968729,0.00909303,0.006842902,-0.058245704,0.009195415,-0.037482154,0.02628289,0.06820032,-0.047222305,-0.017260723,0.08942773,-0.025112301,0.032100596,-0.04803907,-0.12518117,-0.07715899,0.051776107,0.06754595,-0.07007733,0.082014024,0.05359494,-0.07144775,-0.045326192,-0.03084564,-0.008693715,-0.09763204,0.019673651,0.001514195,-0.014028455,-0.049618147,-0.030599223,-0.014790502,0.032437712,-3.0380398e-33,-0.0140764,-0.051333047,-0.01731965,-0.08478567,-0.036352426,0.055500045,0.080805786,-0.028814886,-0.071704455,-0.05642986,0.05827386,-0.004483247,0.048990164,-0.0108084455,0.05865717,0.021329984,0.038120702,0.13227259,0.046600476,-0.066077456,-0.0216234,0.023551883,-0.092246264,0.081288114,0.04686778,0.013150495,0.011045699,0.09744416,0.019607132,0.033817496,-0.02317942,0.035900127,0.0034587933,0.02980068,0.014900822,0.067028634,-0.05861342,-0.022083532,0.019939242,-0.015409644,0.055117045,0.076320305,0.013490955,0.10917039,-0.024434077,0.06524618,-0.06682188,0.051267784,0.032246847,-0.072511666,0.028268186,-0.01377322,-0.004257028,0.05969934,0.014508932,0.008638436,-0.031284943,0.021990145,0.022799835,0.03596347,-0.0225653,-0.07820183,-0.04119397,-0.069240645,-0.007883124,0.05425391,0.049262412,0.061716978,-0.0071321824,-0.11493072,0.06480242,0.060854204,0.009130445,-0.021966249,-0.04123153,-0.09630591,-0.010807982,-0.051731393,-0.07617457,-0.111111395,0.006248229,-0.00843733,-0.018258372,-0.037059404,-0.008551116,-0.00021557328,0.059934482,0.06601833,-0.04011582,0.042951062,0.007866235,-0.06328503,-0.048468873,0.063707195,0.056938924,-4.3099057e-08,0.033686776,-0.11905755,0.03203378,-0.04814264,0.02283642,0.15922315,-0.09961472,0.002114297,0.01579735,0.03972686,0.068770394,-0.018977012,-0.06294335,0.013709205,0.009523603,0.07443821,-0.023136372,0.08340483,-0.021736192,0.0030475524,-0.08159644,0.07091109,-0.1022021,0.02227282,-0.030359734,-0.005023887,0.013453337,0.058623012,0.06609816,-0.11214718,-0.015496173,0.07425339,0.016394753,0.014971877,-0.06960975,-0.021409089,0.074373476,-0.027503405,0.043655038,-0.04603416,0.043731812,-0.0100028375,-0.023777794,0.009918128,-0.05503075,-0.027907182,-0.0675781,0.015971784,0.040754672,0.0076523484,0.10350514,-0.003931951,0.05131249,-0.059262715,-0.079568975,-0.028856097,-0.09312854,-0.034014903,-0.027366064,0.06085543,0.028256292,-0.060379617,0.16648471,-0.064870074 +2.2.1.14,"The enzyme, characterized from the bacterium Bacillus aryabhattai SOS1, is involved in a degradation pathway for 6-sulfo-D-quinovose. The enzyme can also use D-erythrose 4-phosphate as the acceptor, forming D-sedoheptulose 7-phosphate.",384,1.0,-0.07462352,-0.03226781,-0.066941194,-0.035373982,0.024946546,-0.009113069,-0.02974869,0.029995019,0.060259737,0.019062439,-0.0004423501,0.025695695,-0.052865706,0.05758597,-0.06316918,0.041197125,-0.057129476,0.03385573,-0.021458805,0.020590447,0.09351956,0.031043049,-0.01523555,-0.0061106747,0.112206616,-0.011770266,0.048753068,-0.039817642,-0.040832195,-0.075464346,0.039620843,-0.03231011,0.03710781,-0.021030646,0.054126147,0.11854953,0.049957596,0.0010742176,0.042770915,0.032705035,-0.007030791,0.022181327,-0.024572054,-0.055832192,-0.056429368,0.0072532706,-0.052684117,0.06341992,0.059978,-0.050498348,-0.06080485,-0.011427248,-0.05279033,-0.0009783976,0.04319316,-0.0124997245,-0.04625539,0.020242274,-0.01915265,0.0040305783,0.059429787,0.012626994,0.0807903,-0.0051936316,0.04692151,-0.043479122,0.032563902,-0.06638912,-0.034394298,0.016002502,-0.11469687,-0.026861632,-0.0018961858,0.05158978,0.020246437,0.039071042,-0.059931345,-0.05284341,0.037774518,-0.09058976,0.061883874,0.010323236,0.038600653,0.105839044,-0.03562476,0.010887735,0.019565022,-0.02497604,0.075225644,0.00034534436,0.064229496,-0.05660451,-0.0136452615,-0.10799094,-0.032001805,0.02991456,-0.01918285,0.022347357,0.046992216,0.0039398884,-0.05087514,0.050100226,-0.039448757,-0.05585338,-0.027380822,0.006007546,-0.022073874,0.107280195,0.06595607,-0.02726537,0.01974948,-0.020445598,0.06730909,0.029184483,-0.027989846,0.049714707,0.017472155,-0.008112402,-0.07962965,-0.015299623,0.016237851,-0.01460206,0.0054688933,0.055895902,-0.020334471,0.045282934,-0.062221017,1.6290715e-33,0.08834343,0.02708634,0.031786803,-0.052889742,-0.07001045,-0.06124272,-0.0654786,0.030362956,-0.08467798,-0.04012374,-0.07989863,-0.1598355,0.020796642,0.038200613,0.02214374,0.052950095,0.0010571256,-0.0015492907,0.067762285,-0.063388735,0.032009345,0.036764007,-0.035709262,-0.036608044,0.0796785,0.06208675,0.059125397,0.08698493,0.0065169847,-0.028164234,0.06998067,-0.08112546,-0.108351685,0.012875568,0.06811415,-0.026087748,-0.053899795,0.046761233,-0.033998825,-0.0043003014,-0.021422569,0.047426324,-0.023485154,-0.009541047,0.031876303,-0.06122797,0.010119078,0.14124654,0.05639015,0.050033886,0.0014185691,0.0033753342,0.06993624,-0.02033306,-0.05968058,-0.034291785,0.032808304,-0.054109097,0.04199158,0.031374168,0.04562518,-0.029964913,-0.061311893,-0.013949645,0.06326469,-0.015665572,-0.018802352,-0.04220546,-0.013078377,0.026576694,-0.09140826,-0.026178451,0.014158343,-0.009598887,-0.05908053,-0.034037545,-0.03380194,-0.017562388,0.0291324,-0.032192063,-0.028007604,-0.047983654,-0.041582562,-0.02926567,-0.06572179,0.00089736225,-0.029823454,-0.0815056,-0.057670467,0.025491908,0.008473478,-0.11944544,-0.076571345,0.05456345,0.02907896,-2.300938e-33,0.03438405,-0.027962634,0.029884031,-0.03154102,-0.07197416,0.039064895,0.07779873,0.069529384,-0.02343279,-0.042656124,0.035587475,0.019635024,0.029975051,-0.018984811,0.019585626,0.07093946,-0.013919965,0.029592607,0.009485931,-0.015507042,0.018237961,0.13639735,-0.046844,0.014260386,0.070948415,0.05991791,0.027868068,0.05802761,0.002790018,0.080575034,0.035367608,-0.011250927,-0.013033753,-0.00658719,-0.09064643,0.049816873,-0.05554926,-0.01755534,-0.015034167,-0.019374507,-0.007292559,0.010217507,0.047265217,0.03855467,0.05695548,0.039117213,-0.0365579,0.08598778,0.06404398,-0.045632213,0.003061099,-0.0005149973,0.03150704,0.017253218,0.028849946,0.06319867,0.03047831,0.013309111,-0.118551925,-0.04892165,-0.03820021,-0.05747273,0.10234291,-0.010890536,0.051380113,0.06342948,-0.023732774,0.028385764,0.035190467,-0.11021636,0.052973974,-0.04180177,-0.0073264125,-0.018995982,-0.045757953,-0.06614929,-0.107150115,0.065248355,0.010950763,0.090111494,-0.04800831,0.032130234,-0.058822416,-0.047451224,0.0424542,-0.061177246,0.03091092,0.10455325,0.02127722,0.057187144,-0.031929225,-0.031659313,-0.011899978,0.032550346,0.049554422,-3.399203e-08,0.02869086,-0.08650079,0.034101065,-0.032423705,0.028556889,-0.023636587,0.024967415,0.07585255,-0.0067889607,-0.010252187,-0.0337843,0.11203223,-0.02854156,-0.010981576,0.086670704,-0.026895182,-0.07658959,0.0359256,-0.065719984,-0.056135595,0.0006425186,-0.09804284,-0.11298853,0.045304254,0.07694796,-0.057322055,0.036417697,0.016068418,-0.01024655,-0.0074870056,0.010386128,-0.003683337,-0.008990375,-0.05625925,-0.04873933,0.04650522,-0.08693753,0.0004983226,0.04101706,0.05284416,0.0022922722,0.020682165,-0.07524921,0.03151311,0.009308923,0.0486594,0.0058847517,0.039073333,-0.077311635,0.02029149,0.03754676,-0.072750695,-0.057223823,-0.02768033,-0.11232311,0.01674067,0.02225311,-0.035340082,0.02872411,0.010457253,0.058635592,-0.014002501,0.18089634,-0.06567697 +2.3.1.301,"The enzyme, characterized from mycobacteria, provides a link between the type I and type II fatty acid synthase systems (FAS-I and FAS-II, respectively) found in these organisms. The enzyme acts on medium- and long-chain acyl-CoAs (C12-C16) produced by the FAS-I system, condensing them with malonyl-[acyl-carrier protein] (malonyl-AcpM) and forming starter molecules for the FAS-II system, which elongates them into meromycolic acids. The enzyme has no activity with short-chain acyl-CoAs (e.g. acetyl-CoA), which are used by EC 2.3.1.180, beta-ketoacyl-[acyl-carrier-protein] synthase III, or branched-chain acyl-CoAs, which are used by EC 2.3.1.300, branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase.",384,1.0,-0.067197695,-0.07731947,-0.097325906,0.0033926745,0.07314282,0.026089158,-0.08441683,0.079445966,0.07140341,-0.06602754,0.04147175,-0.07321322,-0.024888445,0.0030598545,-0.033301704,0.008820197,0.0014531973,-0.016246969,0.033088937,-0.04682745,0.035876364,0.0375378,-0.037772816,-0.0064673745,0.0016686165,-0.024806352,0.036221378,0.035772298,-0.03697608,-0.13705339,0.023043945,-0.074486695,0.08176998,-0.019694425,0.054982558,0.016038828,-0.0073013785,-0.09014284,0.08945562,0.0010443307,0.09176603,-0.051699948,0.026801778,0.013002725,0.006253963,-0.050538413,-0.053176373,0.041838042,0.0111387195,-0.018605238,-0.0697506,-0.06655734,-0.05763396,0.053455707,-0.01957715,0.025228415,-0.07598244,0.009470829,-0.012070686,0.021985844,0.016190572,0.014674439,-0.0026502267,0.0145782605,-0.03385025,-0.033913244,0.00935674,-0.0453808,0.0700731,0.0077835172,-0.13250586,-0.061162155,-0.036816776,0.10912009,0.04362152,0.018052226,-0.01815688,-0.041402288,0.03396621,-0.00075142994,-0.07234889,-0.021096746,-0.014770838,0.011979714,0.010244871,-0.07643622,0.08607344,0.013257427,-0.005590484,0.045576457,0.07368532,-0.07636088,0.036922205,-0.026594471,-0.021871053,0.041769072,0.08005706,0.0143040875,0.045996476,-0.032375265,-0.005040276,0.016729815,0.014989305,-0.06527518,-0.022468973,0.010033211,-0.057477303,0.096915305,0.03221251,0.021969002,-0.01620055,-0.039058685,0.004335719,-0.034363303,0.041521907,0.06758177,0.03268884,-0.078677714,0.012972855,0.05080919,0.0042190505,-0.06616362,0.055821735,0.0099553,-0.0338486,0.05010531,-0.13709377,-3.6097101e-34,0.007720679,0.011607241,0.029073665,0.012965616,0.027514085,-0.08069248,-0.10296679,0.0649492,-0.041982096,-0.009849626,-0.0010814345,-0.032837976,0.008696127,0.032678828,-0.012013235,0.0016306203,0.052526712,-0.037441984,0.05750623,0.030482842,0.022541078,0.049556486,0.0644773,-0.0017151475,0.06470167,0.04723676,-0.004853054,0.025555814,0.05045576,0.031773858,0.0048148176,-0.08497087,-0.06065168,0.0065922355,0.003636778,0.005949069,-0.016794112,-0.04800682,0.028064065,0.047720656,0.10791751,0.02524337,0.014349668,-0.044445984,0.06336411,-0.055430025,-0.056398626,0.09006141,0.03481512,0.038647763,0.05250937,-0.07019598,0.079002865,0.011470263,-0.0010335768,0.029930184,-0.10973264,0.034616318,0.014311052,-0.034765646,0.016712043,0.08642234,-0.028289367,0.08770738,-0.0706223,0.018373933,-0.0790385,-0.005965047,-0.025352927,0.071565375,0.00689331,-0.014659196,0.054730132,0.033358663,0.11987405,-0.056144472,-0.10114239,0.010350798,0.021741124,0.015177127,-0.008425235,0.03414432,0.029845512,0.011019093,-0.03380572,-0.049711846,-0.08125146,0.03827831,0.026518246,-0.0036378924,0.0069095977,-0.04646162,0.008245731,0.0986275,-0.011475997,-1.8260032e-33,0.13351022,-0.12703006,0.0927933,-0.13966659,-0.033160653,0.03332961,0.041302953,-0.023399286,0.04374122,-0.021048369,0.105242856,0.020834172,0.01840314,-0.064244,0.035719965,-0.009142236,-0.041495793,-0.0037679905,-0.013846017,-0.016567107,-0.014558269,0.015661903,0.032305427,0.03510831,0.032987006,-0.004922789,-0.04224697,0.0888157,0.03100912,0.07819976,-0.011066319,-0.005600564,0.018125655,-0.08852939,-0.096971266,-0.017429557,-0.11361537,-0.0030332948,-0.012585125,0.0014504567,0.04414233,0.02857817,0.0064280983,-0.024474692,0.04073821,0.03957705,-0.0037104897,-0.04859586,0.041355934,-0.11817943,-0.030835219,-0.052287597,-0.0478191,0.0038649708,-0.00498001,0.101170026,-0.010345884,0.053658597,0.017861675,-0.08726682,-0.07156482,-0.10144701,0.019831631,-0.028856054,0.08559017,0.045265727,-0.051844425,0.035519272,0.033059254,0.009114489,0.057820998,0.053805076,-0.029116109,0.0016033796,0.0030770362,-0.02846658,-0.057702783,-0.013010428,-0.030034395,-0.058188792,-0.037048645,-0.022093648,-0.056633044,-0.05421848,-0.08118538,-0.037143994,0.017386062,0.08468194,-0.03936583,0.07068932,-0.019266944,0.030445542,-0.035063937,0.05462578,0.04313904,-4.674594e-08,0.040725794,-0.026809083,0.07294851,0.008080848,0.036116518,0.05394227,-0.060986977,-0.0026573243,0.046150442,-0.0048914994,-0.08769296,0.08759338,0.080562964,0.007466441,0.0036119828,0.020357285,-0.03486812,-0.014337268,0.013611625,-0.05210733,-0.080810286,-0.005432466,-0.004397982,0.057307135,0.021753056,-0.051149867,0.029723233,0.014298906,-0.03605661,0.02295044,-0.049327582,0.061973818,-0.0024793104,0.009032533,-0.049563456,-0.037123404,-0.017877676,-0.09022011,-0.060031597,0.07957484,0.12193363,-0.0006179966,-0.07253536,0.0058758515,0.06806035,0.023961818,0.044165216,0.031396322,-0.029670075,-0.044465434,0.01767167,0.020128058,-0.08152035,-0.006653214,-0.006709518,0.03912203,-0.021567551,-0.06818601,-0.019781025,-0.026222851,0.06040289,-0.030939372,0.15401697,-0.033744752 +2.3.1.302,"The enzyme participates in the biosynthesis of avenanthramides, phenolic alkaloids found mainly in oats (Avena sativa). It is related to EC 2.3.1.133, shikimate O-hydroxycinnamoyltransferase. The enzyme from oat does not accept feruloyl-CoA as a substrate.",384,0.99999994,-0.0109290555,-0.040961806,-0.10906714,0.009111506,0.053039122,0.012447709,-0.097141065,-0.003043644,0.10035468,-0.09284977,0.048790015,-0.023776423,-0.046957172,-0.041501123,-0.06396127,0.060512565,-0.045768075,0.025194898,-0.013719387,-0.061001506,0.023830878,0.0125123495,0.06352283,0.0032862804,0.014369738,-0.030065663,-0.011112728,0.007558196,0.011425809,-0.08041375,0.09114019,-0.028973369,0.01918461,-0.0375268,-0.01734437,0.043809943,-0.018573772,-0.05995481,0.015219836,0.025229579,0.015843367,-0.061503503,-0.0563659,-0.013127339,-0.040966224,-0.091212384,0.016169291,-0.03828012,-0.027206628,0.021632336,-0.044319104,-0.028504008,-0.03787984,0.040151905,-0.025053432,-0.051792335,0.006233944,0.00035662157,-0.034734417,0.06712261,0.00599576,0.05253883,-0.009491545,0.035600524,-0.06689076,-0.01374237,0.013450977,-0.058443185,0.02194447,-0.0677146,-0.022084758,-0.08167875,0.028275242,0.004037664,0.036632303,0.029075667,-0.02457602,-0.026764981,0.015021505,-0.0071840016,-0.022436023,0.0063886493,-0.016134983,0.11013337,0.017933844,-0.01464975,0.00017203378,0.0009292518,0.06307094,-0.001948955,0.063991465,-0.018665599,-0.010728237,0.006217217,0.0021299243,0.01981176,0.062186573,0.02119155,-0.0114198895,-0.041371636,-0.011767369,0.04660062,-0.13472484,0.039408956,-0.0618407,0.020856295,-0.021939758,0.04404077,-0.04304927,-0.024613805,0.035542216,-0.035464644,0.017982107,0.0126581695,-0.047297563,0.05281809,-0.034073494,-0.08481435,-0.037317626,0.0017285021,-0.068621166,0.03313195,0.038564418,0.11771765,0.023061266,0.054088093,-0.1391651,3.796385e-33,0.06916203,0.075979985,0.045943998,-0.084847614,0.028288819,-0.03236862,-0.08827403,-0.013753323,-0.016893348,-0.05653418,-0.109227166,-0.0133428,-0.00039965002,-0.008153337,0.05910176,-0.07809759,-0.010189991,-0.039520267,0.06313857,0.044165917,0.019695891,-0.0028835358,-0.06839534,0.015739584,-0.057593707,0.05776485,0.015478446,0.024151593,-0.0055633523,0.017682146,-0.032009043,-0.11263959,-0.070776485,0.01630414,0.042641472,-0.019310616,-0.035323933,-0.035234094,0.015704002,0.06564874,0.058820497,0.041753694,0.069382556,-0.0040106364,0.07060455,0.009422374,0.025748286,0.17033458,0.097851366,0.06687186,0.018327681,-0.026050817,0.062426597,0.007968149,-0.081331804,0.017320843,-0.08902742,0.0012523631,0.04571773,0.07519774,-0.06028052,0.022096988,0.045469984,0.024418522,-0.03381655,-0.010260715,-0.032163125,-0.03875993,-0.055465817,0.08821823,-0.067165844,-0.009938169,0.05011541,0.016730212,0.06005364,0.0022715705,-0.05153242,0.012497289,0.062364165,0.0023642613,0.06500208,-0.04406226,0.02550109,-0.0044731265,-0.037084065,-0.06343853,-0.034787193,0.0007979982,0.024145251,0.13358901,0.046256516,-0.047060516,-0.049315277,0.051954914,0.007076575,-3.9358956e-33,0.08535088,-0.12442095,0.091423325,-0.09413391,-0.048195753,0.032238178,-0.020159163,0.044179954,0.08491536,0.04015528,0.059283204,0.016647885,0.06076924,-0.10516934,-0.02280516,-0.013311853,0.025928268,0.15172787,0.04087236,0.028234245,-0.08134976,0.02844742,-0.043325316,-0.028828217,0.0726441,0.059518788,0.042630985,0.012003161,0.018111939,0.0027140605,0.030845946,-0.00012120671,-0.07015331,-0.02409344,-0.0037531587,0.054126643,-0.0033278991,-0.0032868695,0.011996612,0.024601385,-0.025832837,0.026050055,0.04115509,0.040216245,0.06227467,0.06698719,-0.097925596,0.056993574,-0.02281406,-0.11035655,0.024001647,0.018771967,0.06275755,0.050223857,0.07175267,0.019136101,0.04296828,-0.004873736,0.0011485276,-0.052918483,0.03997708,-0.022362797,0.03406276,-0.028017582,-0.014740177,0.0009870533,-0.026993494,0.030073503,0.039329138,0.04775627,0.071047865,-0.0066587976,-0.02869386,0.034961946,0.0009426743,0.013301538,-0.022907652,-0.053377647,0.008446758,0.0062073735,-0.018485157,0.0083133625,0.05980153,-0.06259442,-0.077944055,-0.028780432,0.048202444,0.13237095,0.040171657,0.032520585,-0.012501135,0.0071255392,-0.07156447,0.05407935,0.07773436,-3.6556322e-08,-0.0137241045,-0.14178018,0.006079179,-0.016465912,-0.012710575,-0.011588029,0.0067022266,-0.0027396954,-0.009978023,-0.034449846,-0.0424152,0.08965515,0.021569433,-0.040163282,0.00059198396,-0.023576213,0.077114716,0.040448032,0.019036787,0.04550027,-0.06141258,-0.00045887838,-0.028098328,-0.03122365,-0.03321598,-0.054783095,0.03965204,0.011249074,0.037746936,-0.032538768,0.026362449,-0.026302857,0.012352547,-0.06984329,-0.08301349,0.00457716,-0.009148968,-0.096918665,0.03131742,-0.018967854,0.017338954,-0.033522137,1.8980862e-05,0.002542108,0.05421362,0.017913083,-0.013896002,-0.0017305952,0.006085872,-0.04655715,0.020639095,-0.026213376,-0.014004337,-0.07767381,-0.10425493,-0.06735121,-0.046859838,-0.12023801,0.012636271,-0.11503582,0.008472082,-0.0012343517,0.20853639,-0.02556116 +2.3.1.303,"The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.",384,1.0,-0.0011522168,-0.068873756,-0.0699308,-0.002953491,0.024930248,0.0671192,-0.005382308,0.03007029,0.098337255,-0.103692256,-0.009998223,-0.033357725,-0.060999017,-0.010930308,-0.055638634,0.027767882,-0.06280659,0.024212912,-0.071302615,-0.13928024,0.061932646,-0.007507224,0.026039777,0.007661922,-0.039221458,0.014277601,0.05841761,0.072529025,0.07342034,-0.053813457,-0.061165202,-0.067064874,0.0660986,-0.07847665,0.06502655,-0.0039439336,0.039448354,-0.0792064,0.061380126,0.060567826,0.051851876,0.0065076035,-0.043056447,0.002217547,-0.04696287,0.05952476,0.039989844,0.042891193,-0.0123112835,0.0029790376,-0.018276837,-0.08342502,-0.062740155,0.02462527,0.06693863,0.0006259032,-0.11920243,-0.054748125,-0.044618163,-0.045290194,0.030753626,-0.030731477,0.0745331,0.07914109,0.021699889,-0.07863313,0.08430422,-0.029932206,-0.03801691,-0.103401765,-0.03307963,-0.05040382,0.006774394,0.09969577,-0.0069979928,0.029387787,0.04226248,-0.04672996,0.0763649,-0.003166887,0.014309333,-0.029523496,-0.009158531,0.07788508,-0.001751726,-0.041669264,0.009778176,0.0151759265,0.0616008,0.053038254,-0.011515278,-0.085466065,0.038576014,-0.10133463,-0.018702464,-0.017743515,0.075931005,0.013807954,0.07581463,-0.016508546,-0.058555294,0.010839162,0.027523516,-0.07063594,-0.020044783,-0.05394479,-0.006445822,0.09001738,0.007830391,0.0050273836,0.020104177,-0.014131183,0.0013265257,-0.02561218,-0.050533086,0.012804618,0.042699486,-0.06423002,-0.03692366,0.045718968,0.029943861,-0.08553756,0.062401757,0.09548582,0.0008610419,0.064256094,-0.060209833,-2.6433439e-33,0.004127348,-0.008983733,-0.0037035283,-0.023847446,-0.00071257254,-0.03457249,0.008713149,-0.0067721624,-0.06800974,-0.017689941,-0.09815427,-0.08888162,0.058448423,0.0336409,0.03874773,-0.003859176,0.04042601,-0.005439931,-0.07226966,0.021205215,0.064441025,0.10893887,0.009669661,0.025480628,0.02745346,0.023556795,-0.05892282,0.016133238,0.04573424,-0.013264995,0.031801578,-0.023024153,-0.12378898,0.013672435,0.09373456,-0.01645442,0.014282612,-0.005574785,0.032062422,0.04791583,-0.025173081,0.030777307,-0.012896146,-0.039348733,0.07252134,-0.10772661,-0.04590282,0.039188325,0.08569841,0.034451682,0.019002886,0.025175987,0.0954996,-0.07791743,-0.016680587,-0.015746783,-0.029050343,0.028186327,-0.006388819,0.03411311,-0.049144536,0.07231741,-0.029608017,0.05829574,0.0065369313,0.009888238,-0.0008416092,-0.025136514,0.03238423,0.05566664,0.02172436,-0.07146159,-0.009922053,-0.039578497,-0.02959419,-0.048668675,-0.04223014,-0.0013006164,0.044665635,-0.084836446,-0.052553274,-0.015893683,0.029826265,-0.018613763,-0.13571326,0.04188923,-0.035193756,-0.0008465472,-0.046139784,0.06553339,0.04793888,-0.0357728,-0.059832834,0.020527966,-0.010166875,-8.230217e-34,0.062280864,-0.015688973,-0.0056069205,-0.1538548,-0.05350868,0.07736964,-0.021901542,-0.023759943,-0.04095113,0.0047530895,0.053018786,0.017270952,-0.03126478,0.027265536,-0.07814038,0.016459092,0.0032547563,0.10774852,-0.07038247,-0.0399334,0.014935879,-0.0050098156,0.055751245,0.013204764,0.009189835,0.04875905,-0.026096875,0.085746914,0.048125867,0.02067536,0.003954558,-0.01813139,0.01734109,-0.007227925,0.010604088,-0.025509462,0.054736253,0.04134338,0.05836212,0.015019428,0.00960612,0.029616788,0.00015444304,0.10161709,0.02577887,0.05238968,0.03179482,0.011225019,-0.022045797,-0.07478971,0.0069298367,-0.034382828,-0.0077584204,-0.011424791,-0.01806369,0.038340982,-0.00588593,-0.05092703,-0.020330288,-0.07951203,0.0016714789,-0.10323618,0.103057526,0.014863073,0.035065733,0.0344317,-0.040315934,0.031293407,0.013373509,-0.010845459,-0.05122634,0.031391762,-0.047074076,-0.046663746,-0.06192262,-0.05497871,-0.07525177,-0.04998552,0.07137385,0.006571565,-0.06737495,-0.06555118,-0.011859768,0.021964258,-0.04103133,-0.08457543,0.05558344,0.110339746,0.05318324,0.04635013,-0.014455607,-0.012901406,-0.05953771,0.0949073,0.06320879,-2.986254e-08,0.07794061,-0.07474734,0.028595975,-0.0028354267,-0.01562619,0.009654002,-0.09427748,-0.042530853,0.072217576,-0.019392168,-0.024474302,0.078573,0.023542818,-0.04986207,0.057110544,0.05474768,-0.06001291,-0.0557554,-0.015630586,-0.009150145,-0.0335932,-0.060908567,-0.045246515,0.056040563,0.013674776,-0.025573228,-0.041786347,0.053636752,-0.0070210015,-0.00492618,-0.054041706,0.030512167,-0.02805254,-0.0047359085,-0.060480945,0.0042505837,-0.03909867,-0.008261174,-0.020491209,0.057957824,0.053250782,-0.0589071,-0.06258868,0.03803627,0.06396657,0.057140715,-0.058416944,-0.008050627,-0.03135098,-0.083826445,0.011649357,-0.045430463,-0.017217461,0.07582092,-0.09459183,-0.02594987,-0.03743045,-0.029189378,-0.020346444,-0.016723521,0.026992245,0.108342536,0.16905113,-0.036071964 +2.4.1.377,"The enzyme, characterized from several Salmonella strains, participates in the biosynthesis of the repeat unit of O antigens produced by strains that belong to the A, B, D and E 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+2.4.1.378,"The enzyme from Salmonella participates in the biosynthesis of the repeat unit of O antigens produced by strains that belong to the A, B, and D1 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+2.4.1.379,"The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these 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+2.4.1.382,"The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.",384,1.0,-0.0011522168,-0.068873756,-0.0699308,-0.002953491,0.024930248,0.0671192,-0.005382308,0.03007029,0.098337255,-0.103692256,-0.009998223,-0.033357725,-0.060999017,-0.010930308,-0.055638634,0.027767882,-0.06280659,0.024212912,-0.071302615,-0.13928024,0.061932646,-0.007507224,0.026039777,0.007661922,-0.039221458,0.014277601,0.05841761,0.072529025,0.07342034,-0.053813457,-0.061165202,-0.067064874,0.0660986,-0.07847665,0.06502655,-0.0039439336,0.039448354,-0.0792064,0.061380126,0.060567826,0.051851876,0.0065076035,-0.043056447,0.002217547,-0.04696287,0.05952476,0.039989844,0.042891193,-0.0123112835,0.0029790376,-0.018276837,-0.08342502,-0.062740155,0.02462527,0.06693863,0.0006259032,-0.11920243,-0.054748125,-0.044618163,-0.045290194,0.030753626,-0.030731477,0.0745331,0.07914109,0.021699889,-0.07863313,0.08430422,-0.029932206,-0.03801691,-0.103401765,-0.03307963,-0.05040382,0.006774394,0.09969577,-0.0069979928,0.029387787,0.04226248,-0.04672996,0.0763649,-0.003166887,0.014309333,-0.029523496,-0.009158531,0.07788508,-0.001751726,-0.041669264,0.009778176,0.0151759265,0.0616008,0.053038254,-0.011515278,-0.085466065,0.038576014,-0.10133463,-0.018702464,-0.017743515,0.075931005,0.013807954,0.07581463,-0.016508546,-0.058555294,0.010839162,0.027523516,-0.07063594,-0.020044783,-0.05394479,-0.006445822,0.09001738,0.007830391,0.0050273836,0.020104177,-0.014131183,0.0013265257,-0.02561218,-0.050533086,0.012804618,0.042699486,-0.06423002,-0.03692366,0.045718968,0.029943861,-0.08553756,0.062401757,0.09548582,0.0008610419,0.064256094,-0.060209833,-2.6433439e-33,0.004127348,-0.008983733,-0.0037035283,-0.023847446,-0.00071257254,-0.03457249,0.008713149,-0.0067721624,-0.06800974,-0.017689941,-0.09815427,-0.08888162,0.058448423,0.0336409,0.03874773,-0.003859176,0.04042601,-0.005439931,-0.07226966,0.021205215,0.064441025,0.10893887,0.009669661,0.025480628,0.02745346,0.023556795,-0.05892282,0.016133238,0.04573424,-0.013264995,0.031801578,-0.023024153,-0.12378898,0.013672435,0.09373456,-0.01645442,0.014282612,-0.005574785,0.032062422,0.04791583,-0.025173081,0.030777307,-0.012896146,-0.039348733,0.07252134,-0.10772661,-0.04590282,0.039188325,0.08569841,0.034451682,0.019002886,0.025175987,0.0954996,-0.07791743,-0.016680587,-0.015746783,-0.029050343,0.028186327,-0.006388819,0.03411311,-0.049144536,0.07231741,-0.029608017,0.05829574,0.0065369313,0.009888238,-0.0008416092,-0.025136514,0.03238423,0.05566664,0.02172436,-0.07146159,-0.009922053,-0.039578497,-0.02959419,-0.048668675,-0.04223014,-0.0013006164,0.044665635,-0.084836446,-0.052553274,-0.015893683,0.029826265,-0.018613763,-0.13571326,0.04188923,-0.035193756,-0.0008465472,-0.046139784,0.06553339,0.04793888,-0.0357728,-0.059832834,0.020527966,-0.010166875,-8.230217e-34,0.062280864,-0.015688973,-0.0056069205,-0.1538548,-0.05350868,0.07736964,-0.021901542,-0.023759943,-0.04095113,0.0047530895,0.053018786,0.017270952,-0.03126478,0.027265536,-0.07814038,0.016459092,0.0032547563,0.10774852,-0.07038247,-0.0399334,0.014935879,-0.0050098156,0.055751245,0.013204764,0.009189835,0.04875905,-0.026096875,0.085746914,0.048125867,0.02067536,0.003954558,-0.01813139,0.01734109,-0.007227925,0.010604088,-0.025509462,0.054736253,0.04134338,0.05836212,0.015019428,0.00960612,0.029616788,0.00015444304,0.10161709,0.02577887,0.05238968,0.03179482,0.011225019,-0.022045797,-0.07478971,0.0069298367,-0.034382828,-0.0077584204,-0.011424791,-0.01806369,0.038340982,-0.00588593,-0.05092703,-0.020330288,-0.07951203,0.0016714789,-0.10323618,0.103057526,0.014863073,0.035065733,0.0344317,-0.040315934,0.031293407,0.013373509,-0.010845459,-0.05122634,0.031391762,-0.047074076,-0.046663746,-0.06192262,-0.05497871,-0.07525177,-0.04998552,0.07137385,0.006571565,-0.06737495,-0.06555118,-0.011859768,0.021964258,-0.04103133,-0.08457543,0.05558344,0.110339746,0.05318324,0.04635013,-0.014455607,-0.012901406,-0.05953771,0.0949073,0.06320879,-2.986254e-08,0.07794061,-0.07474734,0.028595975,-0.0028354267,-0.01562619,0.009654002,-0.09427748,-0.042530853,0.072217576,-0.019392168,-0.024474302,0.078573,0.023542818,-0.04986207,0.057110544,0.05474768,-0.06001291,-0.0557554,-0.015630586,-0.009150145,-0.0335932,-0.060908567,-0.045246515,0.056040563,0.013674776,-0.025573228,-0.041786347,0.053636752,-0.0070210015,-0.00492618,-0.054041706,0.030512167,-0.02805254,-0.0047359085,-0.060480945,0.0042505837,-0.03909867,-0.008261174,-0.020491209,0.057957824,0.053250782,-0.0589071,-0.06258868,0.03803627,0.06396657,0.057140715,-0.058416944,-0.008050627,-0.03135098,-0.083826445,0.011649357,-0.045430463,-0.017217461,0.07582092,-0.09459183,-0.02594987,-0.03743045,-0.029189378,-0.020346444,-0.016723521,0.026992245,0.108342536,0.16905113,-0.036071964 +2.4.1.383,The enzyme participates in the biosynthesis of the O antigens produced by group E and D2 strains of the pathogenic bacterium Salmonella enterica.,384,1.0,-0.009206363,-0.037293475,-0.02916216,-0.0005880962,0.052481603,-0.0009932197,-0.010269011,0.058882136,0.081970446,-0.030549303,-0.018748969,-0.027824335,-0.07564981,-0.013815194,-0.004057275,0.014624881,-0.021676794,0.021019835,-0.06134246,-0.101609446,0.07728082,-0.020084213,0.0024731292,-0.056751303,-0.032752927,-0.002219433,0.09191322,0.064835034,0.043616556,-0.08597399,-0.039075118,-0.09928255,0.099559195,-0.062401205,0.04441789,-0.0068961945,0.13624926,-0.04268066,-0.0007173082,0.0005340962,0.049197596,0.025860991,-0.008395008,-0.0021185384,-0.039159983,0.025096104,0.040726457,0.06544506,0.015678715,-0.031848412,-0.039667547,-0.048388634,-0.033354975,-0.020119626,0.02885765,0.023118038,-0.03998543,-0.083859585,-0.05410399,-0.054739702,0.04522877,-0.0379567,0.103155054,0.0712017,0.023104493,-0.09572547,0.08349806,-0.03395379,-0.040363338,-0.10415437,-0.08254198,-0.0658031,-0.03433035,0.06759499,0.009540799,0.022821508,0.032297324,-0.01834878,0.08626654,0.017185418,0.040080268,-0.0007802066,0.011119199,0.10503334,-0.03803308,0.022246523,0.014232415,0.022551866,0.07819084,0.06572725,-0.031058183,-0.12100635,0.031200776,-0.047938194,-0.031140735,-0.01743753,0.061408367,-0.0114491135,0.036423247,-0.026688721,-0.07647576,0.06508921,-0.017037,-0.07599555,-0.03211365,-0.07584008,-0.02629181,0.09180853,0.008447422,-0.003941686,0.06601697,-0.031708207,0.023498753,-0.0001796573,-0.07080812,0.025871173,0.010347976,-0.05337647,-0.04303883,0.024933234,0.012956826,-0.04840279,0.024718218,0.08734063,-0.024822645,0.031115307,-0.057471633,-5.8572156e-34,0.028438814,-0.032391343,-0.013977444,-0.019474246,-0.0085208025,-0.030220518,-0.030478776,-0.032941084,-0.038191754,-0.01184074,-0.10278335,-0.13871822,0.06659507,0.053943712,0.070812784,0.007652276,0.01745321,-0.035643525,-0.045621566,0.037598494,0.053786308,0.049699068,0.012005132,0.022123724,0.03618359,0.06563357,-0.050216585,0.026303686,0.077984594,-0.01822707,0.02490772,-0.10866561,-0.11117705,0.057488777,0.090517856,-0.028746834,0.008444194,0.010820958,0.0421728,0.027262209,-0.023361972,0.056451578,-0.02141876,-0.0028636067,0.034031484,-0.10440187,-0.007954674,0.014480623,0.10185485,0.05326882,0.01933461,0.029382061,0.09302612,-0.059908636,-0.044843726,-0.028323973,-0.0005564767,0.01817751,0.034355324,0.017604532,-0.10218753,0.09202042,0.015528676,0.044026133,-0.010469694,0.009369253,0.014687586,-0.05073011,0.026561528,0.096066274,0.0031221863,-0.058179557,-0.023050567,-0.022549309,-0.041056897,-0.050035123,-0.041153874,-0.030746331,0.08048722,-0.043744773,-0.011763618,-0.0013781139,-0.0060391845,-0.0006657092,-0.10050162,0.012148184,-0.08772726,6.0880284e-05,0.0017765685,0.05459938,0.06066439,0.0053280834,-0.056389622,0.013927318,0.02209966,-2.2238441e-33,0.060061336,-0.042218562,0.03022341,-0.11629378,-0.053780846,0.050230287,-0.024887744,0.041250065,0.041281812,0.026134098,0.02501462,0.021357045,-0.020699108,0.027986087,-0.021589331,-0.024347335,-0.009892764,0.110500716,-0.027551183,-0.050307952,0.007792534,0.015871394,0.04583279,-0.024853041,0.028671542,0.049864475,0.014139516,0.054867756,-0.02029952,0.017514978,0.023671422,0.026044903,-0.030631129,0.046837702,-0.035391442,-0.011158828,0.0481577,0.013891094,0.022022024,0.014108954,-0.025832806,0.056379497,0.039091006,0.10554777,-0.0028661976,0.047190644,-0.019166054,0.04717729,-0.012817282,-0.03766462,0.01164407,-0.0012666404,0.025701676,0.00426322,-0.021414895,0.011755857,0.030830631,-0.033051055,-0.04834419,-0.022070348,-0.011917332,-0.10594851,0.0825401,0.018598614,0.024494722,0.0050475774,-0.016344834,0.060441732,0.012779888,-0.029631764,0.024292313,0.011721978,-0.04614396,-0.051999,-0.020162083,-0.054052904,-0.10651296,-0.0070993844,0.11100887,0.02900305,-0.05710386,-0.030079696,-0.029142464,0.016613025,-0.022482054,-0.09140231,0.030486867,0.10395822,-0.004584238,0.046167944,-0.008064226,-0.021474248,-0.053754374,0.08485291,0.082395636,-2.739409e-08,0.057049535,-0.13246529,0.055761576,-0.0077088303,-0.022700945,0.007823304,-0.08707534,0.009671289,0.10088919,-0.018582739,-0.0081237005,0.087308444,0.012679013,-0.045003876,0.06537628,0.056294244,-0.007670346,-0.0045133797,-0.05064503,-0.00036485534,-0.016640898,-0.0698828,-0.07127345,0.0028822958,0.010469006,-0.052562084,-0.025739389,0.005034682,-0.038965885,-0.012596154,-0.080591194,0.0026213664,-0.038815748,-0.036510754,-0.101508334,-0.024256902,-0.023182355,-0.059619155,0.0024401871,0.008311885,0.042371824,0.01533429,-0.02589548,0.0060295817,-0.0047775554,0.08320632,-0.027630562,0.03748454,-0.06580288,-0.096631885,0.013479979,-0.075282514,0.0064622965,0.0022071449,-0.15302382,0.0046102935,-0.032964922,-0.06453601,0.012825841,0.017095065,0.026607202,0.103888415,0.17748435,-0.048771318 +2.7.1.232,"Levoglucosan is formed from the pyrolysis of carbohydrates such as starch and cellulose and is an important molecular marker for pollution from biomass burning. The enzyme, found in yeast and fungi, requires a magnesium ion. cf. EC 1.1.1.425, levoglucosan dehydrogenase.",384,1.0,-0.051252425,-0.033559345,-0.046129547,-0.057648532,0.08613264,-0.00428456,0.018387483,-0.04957806,0.046517506,0.023044681,0.06703737,-0.044857193,-0.02226357,-0.038629957,-0.08131425,-0.006454087,-0.05271462,0.011393707,-0.06069379,-0.0075187767,0.14049424,0.06455437,0.04228169,0.06267703,0.06839327,-0.042940408,0.010052689,-0.038947724,-0.03913353,-0.015489734,0.06167269,0.039078,-0.023734681,-0.066419706,0.02830047,0.06556785,-0.020617345,-0.037205465,0.052839104,0.0011675904,-0.028930273,-0.10635592,0.03321743,-0.07681598,-0.014288158,-0.04191507,0.027756365,0.0024068174,0.016697923,-0.012772754,0.011212592,-0.03911884,-0.016576627,-0.049169634,0.034851443,-0.04492527,-0.06934161,-0.023956068,-0.029510777,0.007406526,-0.01825989,0.096640885,-0.08307218,-0.010257398,-0.0038427596,-0.012109568,0.012284889,-0.08667886,0.024161447,-0.008151217,-0.04135432,-0.037854876,-0.00729548,-0.059971895,-0.016325554,0.028291918,0.07255761,-0.08801467,0.04275727,-0.025185807,0.049830653,0.07038505,0.06759656,0.07198727,-0.031572476,-0.04760788,0.065222904,0.07614491,0.019203627,0.048820823,0.0549592,0.013392796,0.04082988,0.04128184,0.030165486,0.106746264,0.054696962,0.025290884,0.10919789,-0.040884096,-0.025460726,0.026771344,0.018541044,-0.068460785,-0.035466064,0.07237637,-0.010633126,0.04334569,0.055095594,0.004945075,0.09004449,0.00706984,-0.072238795,0.035857916,-0.027440859,0.039184667,0.07331663,-0.08801862,-0.09770467,-0.012443154,-0.013771019,-0.021407243,-0.0052100234,0.03640802,-0.025062645,0.029721463,-0.106444724,4.067887e-34,0.04714926,0.016497206,0.040732138,-0.020218808,-0.017972836,0.03459611,-0.049152996,-0.02931215,-0.02361547,-0.0281308,-0.09947757,-0.04032141,-0.057574037,0.08218132,-0.047454666,0.014896957,-0.049880885,-0.04719958,0.039973155,0.010318591,-0.077064805,0.098640695,-0.03495031,-0.09153778,0.0056944694,0.073504806,-0.03228968,-0.040277738,-0.041682485,0.011418113,0.11658266,-0.0729463,-0.07397938,0.057704017,0.07564395,0.04984071,-0.03455528,-0.0051702764,0.009855198,0.023300368,-0.0006573116,0.0037895667,-0.055475753,-0.003965384,0.016310906,0.02061843,-0.03774126,0.053825494,0.052621324,0.051719684,0.0500779,0.079933,0.029095437,-0.039892606,-0.048193462,0.09038999,0.0072588027,-0.0039438,0.08252663,0.08794542,-0.035423197,0.09804941,0.031691644,0.083446264,0.04093115,-0.04494195,-0.0029088731,-0.030333163,-0.017426815,-0.04436513,-0.026265258,-0.08807639,0.047011722,0.029358024,0.029016005,-0.000490329,-0.006213924,0.00046026544,-0.0069169924,0.007528696,0.00075344346,-0.011849539,-0.020904012,-0.09620569,-0.114316925,0.03406257,-0.05804232,-0.02660275,-0.025815992,0.041190967,-0.09773693,-0.011508352,-0.033912446,0.001218545,-0.0010977683,-3.0605946e-33,0.09633496,-0.068088986,0.071400814,-0.027305525,-0.060810823,0.015590269,0.07549327,-0.110527046,0.03478781,0.12385757,0.056972336,-0.01502931,-0.025994705,-0.05511017,0.069110736,-0.026998116,-0.07103807,0.09751449,-0.03792132,0.013196619,-0.023801718,0.0997927,0.0045777536,0.035066996,0.054303758,-0.032986302,-0.021215986,0.013420457,0.007397615,-0.0397259,0.0050540944,-0.006153682,-0.0037419137,-0.10540994,-0.028647445,0.027378706,-0.029508524,-0.022525541,0.024808232,0.07465166,-0.028353421,0.014507728,0.050186686,-0.01568054,0.015783181,0.03750225,-0.057799857,-0.038060322,0.069165304,-0.014713865,0.085947946,0.0038514338,0.007013081,0.012297009,0.075794175,0.05434386,-0.010848181,0.050287344,0.032247547,-0.021428585,-0.045345884,-0.013237017,0.039809126,0.009405847,0.033967026,-0.022598747,-0.019650768,-0.026694287,0.087761596,-1.8956212e-05,0.048091985,0.007185223,0.04287855,0.04803335,-0.069430076,0.024039734,-0.059233356,-0.07293168,0.014518523,-0.06436416,0.06930258,0.045153853,0.021990092,-0.046128623,-0.00490559,-0.1296016,0.07947021,0.054940533,-0.010138469,-0.012844809,0.014105514,-0.013829066,-0.06205773,0.027234234,-0.003507027,-3.419158e-08,-0.035560094,-0.018933455,0.04447722,-0.014260289,0.0028374956,0.030782454,0.12548466,0.030533986,0.038111538,-0.011114846,0.021401374,0.044584196,0.0020606893,0.0070986794,-0.024256462,-0.060141742,-0.015314693,0.009599331,-0.021118201,0.008112624,-0.0061864704,-0.018116485,-0.114684,0.0069776964,0.02291659,-0.09574082,0.051469885,0.05618673,-0.01644037,-0.012213515,-0.014598415,0.04387615,0.006738212,-0.10892122,-0.057849053,0.020108225,-0.056054268,-0.07495901,-0.026942996,-0.03233676,-0.062317923,-0.019577077,0.064582646,-0.08008962,-0.08203553,-0.035443056,-0.061187632,0.06394505,-0.029026069,0.11442952,0.076469846,-0.041218746,-0.011402807,-0.05399371,-0.046517853,0.0007717495,0.009649642,-0.020057814,0.052312195,-0.13465914,0.033591107,-0.0044451556,0.0997213,-0.08051691 +2.7.4.34,"Polyphosphate kinase 2, characterized from the bacterium Pseudomonas aeruginosa, uses inorganic polyphosphate as a donor to convert GDP to GTP. The enzyme can also act on ADP (cf. EC 2.7.4.1, ATP-polyphosphate phosphotransferase), but with lower activity. The enzyme has only a trivial activity in the opposite direction (synthesizing polyphosphate from GTP). The GTP that is produced is believed to be consumed by EC 2.7.7.13, mannose-1-phosphate guanylyltransferase, for production of alginate during stationary phase.",384,1.0,-0.06334709,-0.04926919,-0.024239277,-0.022253454,0.0030575385,-0.009139477,0.028499868,0.0567322,0.022541448,0.05186292,0.045493677,-0.037829973,-0.052121088,-0.008831115,-0.061717678,0.039473042,0.031412352,0.0019104538,0.059281934,0.05734521,0.15424109,0.009941134,-0.061153762,-0.01606005,0.03918496,-0.013437891,0.021992289,-0.015685478,0.0051131793,-0.01297438,-0.10562994,-0.023093222,0.027713938,-0.061672807,0.10006288,0.13748564,0.043194145,-0.051861178,0.04502107,-0.044228967,0.10397239,-0.038417906,-0.021837283,-0.032329757,0.0034018715,0.04908805,0.058671582,0.0663696,-9.2208946e-05,-0.062360525,-0.049866896,-0.009203239,0.024207687,-0.002946112,-0.018153433,0.028222688,-0.04567303,0.012862192,-0.035238434,0.023620764,-0.035904743,-0.02066883,0.028460173,-0.0075450134,0.068734415,-0.034712333,0.08541153,-0.05085967,0.0014412384,-0.016019743,-0.11167008,0.009404717,0.030037686,0.0015599625,-0.021988384,-0.015841478,-0.042101175,-0.06727706,0.05728848,-0.053520035,0.092981905,-0.046715032,0.035882656,0.022682454,0.0044936226,-0.08271573,0.01346048,0.05653041,0.036524627,0.03814954,-0.0374294,0.025596637,0.07959242,-0.059217073,-0.043739896,0.04977874,-0.013070658,0.035004262,0.025018975,-0.0480691,-0.014659746,0.100284636,0.031637207,-0.11485878,0.031979453,-0.016409297,-0.034421835,0.05543866,0.05444152,0.040936787,0.0027919968,0.05525893,-0.0033431428,-0.021120986,-0.0390417,0.0961741,-0.025151799,-0.096011765,-0.089012034,0.031041127,-0.043299034,-0.08457698,-0.026378991,0.07821949,-0.055622913,0.015311223,-0.031217882,1.626061e-33,-0.01874675,0.0106379,0.054520812,-0.08337843,0.018762948,0.041883424,-0.057652522,-0.086185694,0.009835185,-0.08928914,-0.075142786,-0.09680791,0.0074181017,0.08346971,-0.004387501,0.011468291,-0.05586413,0.019078135,0.12418344,-0.004810563,0.03934866,0.033083364,-0.046239212,0.01294759,0.04261628,0.07940259,-0.035673767,-0.0469693,0.020752903,-0.0035949042,0.048529718,-0.04329035,-0.11639845,0.022540338,0.033277083,-0.068789005,-0.045627654,-0.09103238,0.068908624,0.014203797,-0.018331502,0.018786076,0.050894625,-0.02074576,0.029374884,-0.019281453,0.00097583415,0.06108903,0.034517597,0.04761043,0.036399852,-0.037308194,0.0015159098,-0.011441431,-0.06036699,-0.027698208,-0.050532155,-0.046129446,0.057857852,0.06867314,0.027150808,0.027338864,-0.005779974,0.0049791317,-0.055623375,0.007256171,-0.07756571,-0.0714346,0.03871059,0.07833246,-0.020470452,-0.068273865,0.09365753,0.044726312,-0.0118797105,-0.03872081,0.0072595347,0.022136906,-0.025502011,0.07070628,-0.01577889,-0.07466711,0.004343942,-0.04626703,-0.05943987,-0.028692883,0.011976858,-0.020737275,-0.0062995455,0.017075062,0.024620814,-0.03605815,-0.11114247,0.06537116,-0.047815364,-3.6958428e-33,0.11523727,0.007153271,0.082310125,-0.037144605,-0.06701146,0.020763023,0.05203355,-0.036045823,0.066289164,-0.023704736,0.067693785,0.031110363,0.084880605,0.008723229,-0.0048107393,-0.0007995277,0.003910743,0.06374384,-0.06030207,-0.051400334,0.010092357,0.0834134,0.035445172,0.07909801,0.073481135,-0.039823186,-0.04745155,0.060238406,0.0012897856,0.09825373,-0.02155074,0.06583108,-0.090668626,-0.033515453,-0.028589463,-0.020611154,-0.056702007,0.00703712,-0.0042712167,0.03901614,0.03629408,0.045987137,0.019775962,0.0009162101,-0.026820855,0.120264165,0.034869295,0.0019581632,0.0112075815,-0.08264658,0.050976407,0.06544733,-0.054855328,0.048122168,0.005280205,0.042256672,-0.033610404,0.023986265,-0.12089255,-0.071397655,-0.037057884,-0.056964166,0.04635895,-0.065253325,0.029614642,0.07779326,0.039097335,-0.0067607984,0.0025547002,0.04248061,0.0107320305,0.07237746,0.03957718,-0.008886773,-0.04505398,0.05915016,-0.08906355,-0.07076395,0.0014003798,-0.10885754,0.0022043108,0.04362448,-0.006181398,-0.057228662,-0.022499794,-0.033139646,0.022470985,0.08966025,-0.020038866,0.029368797,-0.08259571,-0.030758874,-0.0785968,0.07656183,0.01851336,-4.1304652e-08,0.014106756,0.032768,0.11346832,-0.06312388,0.014396635,0.06089205,-0.033457555,0.059267785,0.059855685,-0.03712665,-0.037377574,0.052035607,-0.010395849,-0.015438728,0.032721687,-0.0047758045,-0.023500564,0.031775385,-0.033938155,-0.103101715,-0.049949855,-0.055405363,-0.096791044,0.09613245,0.022274142,-0.0066546486,0.050891798,0.010218449,-0.0046475064,-0.032219242,0.040408064,-0.005732866,-0.019575521,-0.005345724,-0.0540465,0.010496982,-0.09466392,-0.026295124,-0.03842251,0.0038628539,0.010760067,-0.050582804,-0.019865358,0.035648428,-0.0345413,0.05663061,0.010312316,-0.023336908,-0.011794104,0.031078776,0.10501775,-0.013502314,-0.041820347,-0.04873255,-0.020343387,-0.0024155055,-0.08074749,-0.06153816,-0.03571673,-0.013398054,0.020715782,-0.023908565,0.119283825,-0.033365622 +3.1.1.116,"The enzyme, present in animals, is specific for the sn-1 position. When acting on 1-acyl-2-arachidonoyl-sn-glycerol, the enzyme forms 2-arachidonoylglycerol, the most abundant endocannabinoid in the mammalian brain.",384,1.0,0.017659305,-0.068296544,-0.10583948,0.039058086,-0.0011477872,0.085198924,-0.029128129,0.05248411,0.015606701,-0.007614252,-0.0020946108,-0.0015709647,-0.13930131,0.057843965,-0.08564181,0.030314233,-0.0059682503,-0.031097934,0.007841402,-0.028525926,0.0026448655,0.023873635,0.06200609,0.034226432,0.01425593,-0.0070144283,-0.0032861594,-0.035558518,0.008259184,-0.070788704,0.09105988,-0.08606565,0.03792337,0.07029893,0.0073481067,-0.029194424,-0.09216642,0.03488529,0.054217573,0.0052557467,0.103331015,-0.008334328,-0.093989134,-0.0073758196,-0.029696118,-0.019079372,-0.011800968,-0.008940661,0.0041165412,0.03725754,0.058556955,-0.102342024,-0.04856453,-0.029779486,0.035021797,0.014756436,-0.10774242,0.03302212,-0.033804283,0.07142069,0.048717987,0.0031082223,-0.004206406,0.0066244747,0.096990794,-0.019799743,0.012080871,-0.117583305,-0.01872887,-0.03215011,0.032073494,-0.07581555,-0.0369699,-0.014261036,-0.051265314,0.025448343,-0.036486544,-0.022675741,0.022446746,-0.103703685,0.043540858,-0.01611769,0.026615059,0.07832522,0.058838855,-0.03769674,-0.03702009,0.11220689,-0.012047504,0.025285933,0.056141194,-0.056097403,-0.032508854,-0.062034562,0.007119799,-0.011818469,0.039866667,0.004447513,-0.04102515,-0.008436149,0.019181747,0.026083779,0.02175775,-0.06820716,0.0018939964,0.09648053,-0.023610154,-0.08747191,0.04311622,-0.026661132,-0.001743992,0.026813343,0.025220053,0.042738188,0.04090564,0.004181441,-0.060691096,0.060362384,0.034914263,0.00061956234,-0.0538064,-0.022731151,0.03185802,0.049185764,0.0037499336,0.0014051356,-0.050268266,7.1983725e-34,0.03510589,-0.010846785,-0.05038957,-0.0049140607,0.07102174,-0.02321064,-0.036071632,0.09430724,-0.016832238,0.018369457,-0.037415735,-0.04315845,-0.0017298541,0.029004162,-0.0050608036,0.017121391,-0.030997973,-0.011517024,0.09367071,-0.08985247,-0.059788663,-0.004928593,-0.0679891,-0.030635674,-0.03756067,-0.006442894,-0.02871674,-0.011199366,0.04170438,0.0029595934,-0.03189651,-0.04153769,-0.09466633,0.036859475,0.021462016,0.03168165,0.040363584,-0.004299456,-0.005796673,0.04426481,0.08579216,-0.0033608552,-0.0038179182,-0.020427674,0.012198455,0.0035361417,-0.11570815,0.06130095,0.045660958,0.0336704,0.0076570776,-0.08039884,0.09398117,0.018127203,-0.046293836,0.019695865,-0.0058141835,0.020517543,0.014149384,0.018603373,-0.009966236,0.031537596,-0.0600777,-0.0074769612,0.04040855,0.010240815,-0.0936802,-0.08018684,-0.019571656,0.023417037,0.011674892,-0.011384873,0.07459593,0.022269646,-0.01596619,0.0042160866,0.02306813,0.10424614,-0.0183337,0.040236235,-0.024256045,0.042774323,-0.009290908,-0.027970389,-0.049679488,0.011772902,0.030006409,-0.12430797,-0.048068993,0.0034370713,0.039668713,-0.043098222,-0.03932766,0.018746613,0.04629012,-1.2184188e-33,-0.034171153,-0.109802656,0.07387839,-0.04884009,-0.07308,0.13001122,0.06840363,-0.012461786,0.0034495813,0.04492123,0.10095688,-0.01210842,0.077296175,-0.021531593,0.06923592,-0.058075123,-0.05872488,0.08233286,0.07110842,-0.037204962,-0.051031224,0.09072469,-0.04796799,0.07636335,0.04372157,0.06570643,-0.037844818,0.045127586,0.03683484,0.06894538,0.0016624366,0.079438545,-0.0322751,-0.065004244,-0.04889991,0.04775648,-0.05222474,0.006232588,-0.07531217,0.028734839,-0.0071586003,0.038542874,0.07212636,0.10212753,0.14130074,0.06346473,-0.01704562,0.023781823,-0.0321351,-0.08180797,-0.007845601,0.014468579,-0.061515022,0.014658686,0.081973426,0.06938239,0.035199568,-0.061297208,-0.036611468,-0.14292866,-0.04116567,-0.012095447,0.010815916,-0.02455161,-0.0035770473,0.007279288,-0.01947681,0.0070676296,0.10442646,-0.046200633,0.070545234,0.00594742,0.04781436,0.07783336,-0.04731131,0.07184222,0.021855272,7.842646e-05,0.03503454,-0.05585848,-0.017514303,0.050125096,-0.05377782,-0.036898516,0.006099784,-0.03253754,0.01359991,0.10168626,-0.00120181,0.008533079,-0.051281594,0.040190104,-0.09468701,-0.008469727,-0.0141954245,-3.4843247e-08,0.011014548,-0.06518475,0.06210878,-0.050579842,0.012142051,0.046508636,0.05932592,0.03696082,-0.016827138,-0.12387085,-0.045960054,0.010496636,-0.012466918,0.06844133,0.020598108,0.07299862,-0.012724407,0.048674304,0.0074362657,-0.037719496,-0.103868,0.005174932,0.0054158196,-0.07862516,-0.070354946,-0.038800478,-0.06900364,0.121977806,-0.042398483,0.020448735,0.06498274,-0.039037798,0.028271819,0.011517475,0.022249367,-0.0068971138,-0.00045304807,-0.014485485,0.020080889,0.0144154625,-0.010266734,-0.024685709,-0.0093584135,0.043979317,-0.0015340713,-0.054359876,0.07845252,0.030835362,-0.005468759,-0.043952417,-0.032338012,-0.026638316,-0.020422367,-0.10227637,-0.06131608,-0.059614472,-0.024410551,-0.06339941,-0.074621856,-0.059282728,0.01783004,0.088941,0.10220783,0.0024405695 +3.1.1.117,The enzyme occurs in microorganisms and catalyses the cleavage of the ester bonds between glucuronoyl or 4-O-methyl-glucuronoyl groups attached to xylan and aliphatic or aromatic alcohols in lignin polymers.,384,1.0,-0.0323762,-0.098170206,-0.06918018,0.002421904,0.055786554,0.026295522,0.0056108097,-0.022654066,0.07191975,-0.04012275,0.08197787,0.008038253,-0.112609126,0.027928216,-0.028527064,0.07072575,-0.069841504,-0.00863044,-0.035462428,0.004890599,0.11645707,-0.0061626085,0.00505337,-0.0015591905,0.039898627,-0.033012927,0.06444738,-0.10131989,0.051435422,-0.06604568,0.032542024,-0.036314745,0.06451665,-0.0040304186,0.054422155,0.07265928,-0.020293413,-0.109908015,0.029838858,-0.028400784,0.08369263,-0.07080901,-0.038988534,-0.051528584,-0.06469008,-0.0025631085,0.019645106,-0.02690494,-0.033200614,0.007862548,0.023894591,-0.06561414,-0.025193501,-0.00680221,0.021535525,0.025684133,0.013334682,0.02019687,-0.042454287,0.070963845,0.03829317,0.10664022,-0.015034503,0.006721638,-0.082139455,-0.040161464,0.06351983,-0.010949625,-0.0054094535,-0.033338036,0.011181795,-0.04115538,-0.034101963,-0.03002113,0.024447415,-0.0319872,0.010000996,-0.069056645,0.05911043,-0.007041036,0.03978634,0.06922356,0.030447336,0.073126465,-0.01015331,-0.022752743,0.016420146,0.034310464,0.011476662,0.032953963,-0.0041108862,0.0065460242,-0.061665777,-0.06796963,0.015556255,0.060011186,0.10553054,-0.0036539158,0.06328114,-0.014165199,0.022811359,0.0027175564,0.026528982,-0.12457948,-0.11682671,0.0050652865,-0.030735217,0.03609999,0.06754577,-0.0033114108,0.018661207,0.043949783,0.05821133,-0.02604496,-0.10124703,0.08400775,0.08644428,-0.044070456,-0.09994888,0.005593571,-0.03339486,-0.026743358,0.05567549,0.12002781,-0.050002128,0.008925449,-0.08273391,3.0202289e-33,0.008890897,-0.021861594,-0.05017345,-0.029251948,-0.023479324,-0.059730157,-0.043683466,0.010501846,-0.06642056,-0.029480066,-0.038070988,-0.070300736,-0.0068458,0.015348165,-0.011532207,-0.0009931977,-0.0028139118,0.026367413,0.039541706,0.032748837,0.020919153,0.009710751,-0.07675204,0.02789139,-0.026039615,0.06122367,0.017746156,-1.461666e-05,0.017598698,-0.0504784,0.039069116,-0.06632982,-0.07677317,0.061086427,0.07367887,0.04938922,-0.0053390726,-0.04772139,0.0014077653,0.0076500606,0.032400753,0.029173853,0.008466362,-0.046782684,0.024672562,0.017044531,-0.044984307,0.047053706,0.039378315,0.041870467,0.052412122,-0.033504438,0.042810686,0.09039189,-0.043782108,0.06725667,-0.06556161,-0.11625764,-0.01964847,-0.044585906,0.07476478,-0.003368711,-0.05594443,0.00026431636,0.01738756,0.017488023,0.010416763,0.020703178,0.04980136,0.05010038,-0.059553284,-0.07630112,-0.03670635,-0.009263308,0.0026626408,0.0063747326,-0.095108956,0.0106873335,0.04828087,0.056918908,0.006621679,0.023804946,0.054950822,-0.089831054,-0.11830062,0.0062225373,-0.014423314,-0.0010753173,-0.00667985,0.02851617,-0.032369144,-0.10044994,0.022944296,0.03969866,0.0021495384,-5.8113693e-33,0.07649197,-0.13440195,0.060372524,-0.07935067,-0.04058822,-0.0177653,0.02181953,-0.024576735,-0.030576589,-0.001167995,0.040505562,0.005508376,0.037598412,0.022437677,0.045930717,0.047845073,-0.023923818,0.067858614,-0.00026441467,-0.011675548,-0.028442277,0.027052807,0.048829313,0.0020669426,0.032097124,-0.0254114,0.0062336843,0.004498242,0.035324387,0.01117216,-0.06445417,-0.043895215,0.0077885543,0.030396786,0.012975643,-0.016438253,-0.034145977,-0.0058419406,-0.006470756,-0.045811586,0.057970423,0.033648983,0.035358697,0.04042604,-0.0029564134,0.045049883,-0.12684609,-0.021044845,0.0027720404,-0.028399408,0.030202739,0.06267179,-0.040280964,-0.015321504,-0.0043006907,0.06587504,0.00830614,-0.014854559,-0.043734804,-0.016704254,-0.1118662,-0.035655577,0.039545238,0.02825368,0.026281146,0.07580552,0.01305347,0.06346738,-0.019146057,-0.09230768,0.108718015,0.03922875,0.002405778,0.105666324,-0.078647,-0.05585235,-0.040946554,-0.040154103,-0.01952883,-0.08648442,0.08784237,-0.024863152,0.001722996,-0.074804135,-0.07135858,-0.06571231,0.08050889,0.11897466,0.012422549,-0.011874527,-0.040587097,0.05227715,0.020205544,0.060183667,0.03633072,-3.813918e-08,-0.13837317,0.013939233,0.02922291,-0.042230185,-0.04746263,0.020098332,0.043100815,-0.018531788,-0.0047288286,-0.0427288,-0.030064737,0.056991465,-0.07003665,0.04881362,0.026691554,-0.0030880761,-0.08394444,0.011173778,0.010794495,-0.037805792,-0.0708853,0.019492216,-0.060970936,0.03959544,-0.046623256,-0.06330665,-0.006485864,0.10755094,0.05251846,-0.0057942597,-0.039852202,0.09461197,-0.02161319,-0.0016387564,-0.024739213,0.080661714,-0.044192087,-0.064223155,-0.022429448,0.040188685,0.012812258,0.0011142847,0.023326362,-0.04065218,-0.022848552,-0.0057048267,0.0010479535,0.0043169344,0.043077752,0.15180978,0.076443955,-0.014338094,-0.030881474,-0.055529132,-0.10238958,-0.065662675,0.0069823964,-0.0055227745,0.013240803,-0.03356998,0.003825391,-0.018590696,0.19671476,-0.015528289 +3.1.4.61,"The enzyme degrades cyclic 2,3-bisphosphoglycerate, a thermoprotectant that is produced by certain archaeal genera. Two different enzymes that catalyse this activity, one soluble and one membrane-bound, have been characterized from the archaeon Methanothermobacter thermautotrophicus.",384,0.99999994,0.0002703539,-0.013043943,-0.06818597,-0.008928182,0.039487872,-0.020669753,-0.05790876,0.018928062,0.07388676,0.014960339,-0.070374414,-0.07487156,0.004182412,0.011625669,-0.063310236,-0.0030962466,-0.06399187,-0.024223324,0.036202837,0.012415148,0.14397903,0.053843405,-0.055117317,0.007255289,0.04873011,-0.015527061,0.004853719,-0.037813526,-0.07233328,-0.007876789,-0.029181683,-0.03486991,0.119467266,-0.01616697,0.09810794,0.10502296,-0.039445747,-0.034986835,0.040141888,-0.009012816,0.053295944,0.01885046,0.03261771,-0.07779749,-0.059218604,0.03950318,0.040983945,-0.0064695743,0.051020134,-0.03454905,-0.05869888,-0.07066249,-0.043791734,0.056517065,0.023647815,0.08207603,-0.023656007,0.008691424,-2.2851478e-05,-0.030863278,0.08653235,0.028953947,-0.0021899452,0.03459636,0.031797033,-0.07707571,0.042066075,-0.07343807,0.06727491,-0.023928944,-0.07740025,-0.0067799687,0.0023417012,-0.07138063,-0.017060827,0.021136783,-0.015714036,-0.07244602,0.038670246,-0.09835738,0.022384034,-0.0682918,0.019541603,-0.015190168,-0.01619391,0.01248239,0.055447046,-0.034133475,0.09713515,0.0014273585,0.024962936,0.0032821381,0.10270261,-0.058409218,-0.08176461,0.018340237,0.04187331,0.028492961,0.026119048,0.008886913,-0.002066807,0.041744843,-0.036007944,-0.093135215,-0.039960466,0.010607291,-0.0012294166,0.052120313,0.049669582,0.046809785,0.024407487,-0.019630466,0.09161369,0.034221258,0.0068855663,0.0820298,0.021138933,-0.065533735,-0.049815457,0.068131454,-0.05857434,-0.05265976,0.06711334,0.02182936,-0.036787406,0.14081486,-0.09177988,2.832732e-33,0.06293434,0.019815665,-0.002473449,-0.04280368,0.028516632,-0.017079676,-0.05609853,-0.00012115487,-0.008289235,-0.046366405,-0.027185293,-0.03679319,0.032197982,0.006360641,0.015252173,0.016414039,-0.046420358,0.014584159,0.037006214,0.029196108,-0.07328843,0.042234246,-0.03600846,-0.038031045,0.08085527,0.01302423,0.02818755,0.0005357718,0.020553596,0.003772893,0.06980177,-0.08299918,-0.18399252,0.026642807,0.102852345,-0.019677196,-0.011667474,-0.0006183089,-0.06635439,0.034993064,-0.007620251,-0.018598748,0.031560168,-0.037704922,0.10076788,-0.009042364,-0.06625109,0.14399576,0.03701188,0.021600734,0.03015395,0.014834047,0.07706501,-0.024723561,-0.10083464,0.0054850597,-0.00011811411,-0.020140402,0.07967919,0.020734113,0.016560491,0.08098553,-0.018714163,0.014348524,0.0076485877,0.02517565,-0.04769509,-0.014542858,0.057313148,0.049100153,-0.079561025,-0.03372816,0.010823641,0.091412336,0.012141771,-0.045492105,-0.001588388,-0.05443558,0.014259319,-0.018463578,0.009660852,-0.0462133,0.061434124,-0.0403712,-0.028854242,-0.0041846964,-0.037640505,-0.052372135,-0.01699697,0.107575096,-0.0047245384,-0.05908809,-0.07570439,0.103667304,-0.06292129,-3.15247e-33,0.077590324,-0.090119705,-0.012743516,-0.04734702,-0.08738123,0.041428596,-0.06191893,-0.009094484,-0.006995945,-0.08425907,0.089149974,0.0021371793,0.12183426,-0.05108414,0.0648419,-0.024408987,0.058770757,0.018359777,-0.0015003104,0.002247245,0.059311215,0.038072105,-0.035630804,-0.004327683,0.002922542,-0.00042911162,0.0071496405,0.053675763,0.046777673,0.04270795,0.0037193105,0.035476565,-0.02802822,-0.092630185,-0.12785436,0.0022060338,-0.08007078,-0.0696905,0.07874503,0.034627814,0.021170331,0.02310378,0.008475773,0.03886184,0.04563061,-9.9389996e-05,0.0011717431,0.00062793633,0.06887651,0.0061147385,0.03399502,-0.12254475,-0.0070118573,0.0121997595,0.024384137,0.019699637,-0.008180304,0.058494885,-0.043669023,-0.020168649,-0.032721058,-0.014458795,0.11010349,0.013763186,0.075423576,0.08931141,-0.050945345,0.03218498,-0.031231046,0.029658461,0.093732096,-0.017277393,-0.0094718635,0.033926327,0.02324797,0.010828867,-0.054465972,0.014658228,-0.007486319,-0.06971243,-0.039206598,0.06317667,0.055849224,-0.052701395,0.01657968,-0.09526024,0.05573638,0.035114877,-0.03911683,0.0271087,0.0041967183,-0.07952879,-0.04569336,0.006308464,0.061190642,-3.443186e-08,0.06009686,-0.003358742,0.04736629,-0.062233552,-0.0017792628,0.005616839,0.050279405,-0.00075694156,0.042527013,-0.07567928,-0.026329674,0.059008364,0.03803234,0.014757645,0.046181638,0.075500056,-0.061041128,-0.043320406,-0.066539936,-0.034804717,-0.027241064,-0.09648581,-0.04845255,0.030644175,0.026545694,-0.0046166517,-0.0051474813,-0.021814669,-0.027643595,-0.007140681,-0.058467627,0.03227144,-0.005287984,-0.055708025,-0.05050901,0.006434376,-0.053954143,-0.055347208,-0.06608841,0.0034026862,0.025063047,0.0013848633,-0.04782474,0.0066700294,-0.02865154,-0.044942703,-0.025128078,0.030671861,-0.030947601,0.021109618,0.07305186,-0.008369649,0.027663033,-0.043279212,-0.10332162,-0.07321317,0.037526112,-0.034295842,-0.075260304,0.0369428,0.057984635,-0.019576583,0.11178128,-0.048223753 +3.6.1.74,"The enzyme, found in eukaryotes and some plus strand RNA viruses (e.g. alphavirus), is involved in mRNA capping. Unlike the eukaryotic enzyme, the viral enzyme requires a purine in the first position of the mRNA. The human enzyme is a multi domain protein that also has the activity of EC 2.7.7.50, mRNA guanylyltransferase.",384,1.0,-0.03401829,-0.08758751,-0.06545669,-0.027125135,0.018913185,0.033227436,0.025326468,0.002691017,0.04230097,-0.001988541,0.017933788,-0.026330693,-0.09746397,0.058989044,-0.028765578,-0.029300094,-0.15199699,-0.05765981,0.018602863,-0.074519604,0.05252329,0.073836766,5.135153e-05,-0.022881312,-0.0029729442,0.03986054,0.047746725,-0.022244979,0.035442963,-0.07236791,-0.031796698,-0.12435152,0.095217936,0.0021925445,-0.0304641,0.1241918,-0.10548779,-0.06827249,-3.5431505e-05,0.07430956,0.02627555,0.032530718,-0.0054729967,0.023883311,0.043342564,-0.008817753,0.014038381,-0.014478856,0.046959624,0.026246361,0.017132465,-0.07061908,0.0074042124,-0.02632518,-0.053902216,0.06860195,-0.025436284,0.009051634,-0.0039933077,0.009937548,-0.014385964,-0.001465741,0.0054488746,0.003319605,0.10619417,-0.09331898,0.07245107,0.047331758,-0.06508458,0.004243195,-0.044861384,-0.035419498,-0.09990808,0.095139034,-0.013429424,0.020241112,-0.020335032,-0.037827373,0.05748521,0.09122094,-0.03225824,-0.07364136,0.061679266,0.034090452,-0.07106319,0.06597862,-0.013053553,0.008735586,-0.051158737,0.029777616,0.010653024,-0.039219823,0.04045582,0.052192852,-0.009225964,0.067985274,0.0063830246,0.08716195,0.027507659,-0.044927344,-0.007310333,0.009118977,-0.02882466,-0.06493339,0.052159958,0.0001097948,0.064376876,0.018506512,-0.029407946,0.012197893,-0.039082255,0.00095426524,0.0056037046,-0.01649723,0.10382272,0.041577607,0.03897372,-0.08038169,-0.007077836,-0.04739031,0.004417337,-0.031933885,0.041093677,0.046179593,-0.044582337,0.0624266,-0.047213122,-1.3244986e-33,0.054349657,-0.049565885,-0.021310791,0.009304202,-0.045446157,0.07734269,-0.08950961,0.03858905,-0.09410254,-0.041241948,-0.042531155,-0.067657664,0.050458796,0.03153421,0.03651137,-0.06645896,0.012994565,0.025240067,0.023525102,0.0057499176,0.08810992,0.02713214,0.018849323,0.06155292,0.005021128,0.025369177,-0.08592736,-0.055579733,0.046872657,-0.022384511,-0.085731685,0.023425573,-0.08559042,0.07927181,0.0029001113,-0.040933862,0.0016539136,0.0016094364,-0.007884133,0.07013598,0.09947008,-0.018967919,0.013227025,-0.051768042,0.08832107,-0.028436411,-0.1166636,0.042766865,-0.06446438,0.0011360901,0.04962275,-0.0019489927,0.07247884,-0.04921508,0.0069481735,0.049035285,-0.006012628,0.015886175,-0.028238883,0.061983615,-0.021426124,0.049543265,0.04613939,0.064976044,0.0022858551,0.020413872,-0.041109715,-0.081438124,-0.019936666,0.12912779,-0.025179941,-0.02509567,0.057468604,-0.007402168,-0.010352323,-0.0015597093,-0.10278836,0.015638229,0.02444348,0.052447364,-0.07068089,-0.0709706,0.043308023,-0.014866565,0.037324354,-0.06387032,-0.02111081,-0.04009631,0.017413426,0.06316717,-0.0015491656,0.022281872,-0.060378358,0.011113063,0.036075383,-1.0020575e-33,0.03023776,-0.0569869,-0.023126677,-0.03188128,-0.05648131,0.0765459,0.08500366,-0.110306256,-0.0005138912,-0.0026393193,-0.023300383,-0.024371034,0.027279563,-0.04087915,0.046896722,0.0042922646,0.0031153949,0.06730371,0.0027241516,-0.033295557,-0.029858582,-0.002659136,-0.0075967573,0.0038182496,0.054555375,-0.03390725,-0.042862393,0.04054818,-0.004462843,-0.033888932,-0.06819827,-0.029282296,-0.01072232,-0.025939465,-0.087224506,0.03274116,0.015805325,-0.013440054,0.09130553,-0.020929035,0.03214764,0.05588617,-0.007875323,0.06672886,0.029321205,0.06145052,-0.036324177,0.010058214,-0.03607549,-0.042232458,0.015636878,-0.036312647,0.079020225,0.037628457,-0.043153297,-0.033962116,-0.0024984083,0.010180915,0.038433984,0.009043684,-0.025552083,-0.07779877,-0.009147715,0.017451892,0.022112807,-0.06507327,0.007920109,0.06490709,-0.0078445235,-0.13957354,0.119009785,-0.05774063,0.026751852,0.0379955,0.0024443446,0.003835648,-0.027493957,-0.05355072,0.049271986,-0.108518206,-0.06354359,0.030526198,-0.04148704,-0.0073978677,0.060067613,-0.023848156,0.029968921,0.043543413,0.024718534,0.04906901,-0.017028974,-0.018008217,-0.06532107,0.012739426,-0.0037876228,-3.6206966e-08,0.010598915,0.0022055686,0.027507838,-0.0624122,0.082163736,0.09363125,-0.0070332205,0.047676027,0.07277897,0.009502285,0.008670125,0.030843522,-0.028913457,0.029121308,0.061726082,0.03172902,-0.075305216,0.07306247,-0.0065533975,0.016026868,-0.05978288,0.035469726,-0.14618482,0.0679529,-0.09183652,-0.028542973,0.031323638,0.095119424,0.010736966,-0.07207089,-0.059463132,0.035532083,0.021707548,-0.059059456,-0.06648649,0.0027678665,0.1324148,-0.057343338,-0.022631634,0.006805514,0.049336467,-0.07496657,-0.023077484,-0.06298883,-0.040479198,0.038018648,0.032155704,0.012110026,0.08025403,0.0012047697,0.0348643,0.0062790355,0.0144852055,-0.020704605,-0.05265614,-0.008825518,-0.047560167,-0.071678266,0.04409808,-0.013545042,0.004101772,-0.012218787,0.18256904,-0.046634678 +4.1.99.26,"This is a bifunctional radical AdoMet (radical SAM) enzyme that catalyses the first two steps in the biosynthesis of the enzyme cofactor mycofactocin. Activity requires the presence of the MftB chaperone. The reaction occurs in the right-to-left direction. The other activity of the enzyme is EC 1.3.98.7, [mycofactocin precursor peptide]-tyrosine decarboxylase.",384,1.0,-0.06624214,-0.07155679,-0.16345689,0.021446899,0.07627556,-0.03681181,0.04386855,0.065019,-0.00606964,0.060532805,0.039276004,0.008997212,-0.059771724,0.098737635,-0.053408835,0.11431657,-0.020096658,0.026354104,0.041772828,-0.018139333,0.008917192,0.05168028,0.0028602746,-0.027007118,0.029931553,-0.009944692,0.038008317,-0.041036934,-0.019863762,-0.05172228,0.030411268,-0.001107002,0.05780287,0.02049374,0.034844987,0.06689354,-0.018364444,-0.11446873,0.06632317,0.015472508,0.024162464,0.019073928,0.045308422,-0.05208869,0.01432966,-0.006022689,-0.032421984,0.018140873,0.039108217,0.06494977,-0.011982419,0.024741678,-0.07069896,0.015619997,-0.02082216,0.015737027,-0.043250524,-0.06708747,-0.025836129,0.035423122,0.052091416,-0.01935378,-0.018384634,0.0011729546,0.010747133,-0.013119566,-0.06721431,-0.06488256,0.07685721,-0.059768416,-0.035189893,-0.0526412,-0.04481902,0.0259509,0.007163454,-0.0045588217,-0.010620481,-0.018795008,0.045734182,0.023489296,0.030774549,0.0022121398,0.0230098,-0.012113181,0.08030066,0.011745645,0.09490051,0.002741487,0.011393125,0.0603417,0.045817625,-0.05490946,-0.031013481,-0.07533936,0.015040903,-0.037888613,0.023165448,0.03690929,-0.052306563,-0.01862263,-0.0142602725,0.027344413,-0.00778622,-0.06049406,-0.037768114,0.028039929,-0.057134714,0.09797281,0.09907005,0.065080844,-0.0553333,-0.020330079,0.033380695,0.014252517,0.0075229835,0.14640827,0.039916366,-0.027598431,-0.013695975,0.028550318,0.08271549,-0.006000261,-0.023711901,0.025494967,-0.110193804,0.03554214,-0.09501603,1.7038045e-33,0.07779715,0.021823462,0.033046156,-0.005598947,-0.023738421,-0.044390824,-0.13595545,-0.025986632,-0.008534254,-0.01977286,-0.011938609,-0.0071341153,0.052041676,0.066730544,-0.14457017,-0.111710034,-0.01569718,-0.03901267,0.049078427,0.009053906,-0.059189312,0.07977283,-0.081004284,-0.016533738,0.0050634965,0.034619447,-0.022076886,0.042213663,0.044629637,0.028551858,-0.0054657813,-0.023984842,-0.114119664,-0.007690047,0.02954097,-0.005529479,0.006363301,-0.15132983,0.023934979,-0.0084437365,-0.005676465,-0.06475053,0.027662225,-0.04006114,0.025318675,-0.09086706,0.043605305,0.062010817,0.026405593,0.01623267,0.0032257256,-0.030505864,0.01620435,0.0058406,-0.01892256,-0.036247503,-0.03271477,-0.010780942,0.08534598,0.07206559,-0.011939266,-0.056203954,-0.09160192,0.11145458,-0.06252867,-0.08035463,-0.08093237,-0.0542273,0.0047736163,0.09320709,-0.0021984868,-0.008548461,0.051793296,0.018224873,0.04781746,-0.0063217427,0.027359303,0.033299927,-0.05272957,-0.05203889,-0.015820248,0.05973874,-0.037225395,0.022428572,-0.011038075,0.018976271,-0.040953048,-0.04671614,-0.053857096,-0.03787791,-0.069919676,-0.012313621,-0.008131575,0.10351576,0.024454303,-3.146269e-33,0.088948786,-0.15669963,0.025264245,-0.099616595,-0.07781013,0.015593467,0.08107132,0.017292527,0.06550601,-0.034365404,0.0372831,-0.0592625,0.05396943,-0.109303795,0.043813765,-0.0056594643,0.03672799,0.04008388,0.012798823,0.02228749,-0.011147865,0.07433163,0.055106405,-0.06644,0.026952744,-0.027374087,0.026142903,0.050325666,0.04014299,0.082682006,-0.039996855,-0.05400434,-0.032382812,-0.040726867,-0.08271833,0.057907756,-0.057400834,-0.058679152,-0.011533914,-0.06246802,0.0061186827,0.014090504,-0.004053106,0.06066174,0.020299086,0.0028073655,-0.06399029,0.030141525,0.04539693,-0.078843094,-0.057318527,-0.01258333,0.02465286,-0.024838109,0.004407242,0.07288373,0.07034079,-0.04136659,-0.012265409,0.023858156,-0.017514156,0.06661904,0.05466534,-0.05460077,0.0634926,0.035400208,0.0046056425,0.045207497,0.06700344,-0.010632131,0.101212904,0.018771868,-0.04650909,0.07461339,0.035583,-0.11092871,-0.068635374,0.016182294,0.049544193,0.009551407,0.005980588,-0.0024757844,-0.017115317,-0.06854577,-0.0042416896,-0.059949517,0.019487577,0.15171212,0.0019211614,0.00536815,-0.0077842386,0.007991271,-0.05778703,0.07093822,-0.0019210039,-3.823639e-08,0.0020329442,-0.04836689,0.08230719,-0.052184094,0.011244212,0.05544359,0.052257735,-0.03104866,-0.07596056,-0.042451322,0.036248207,0.056337323,-0.013734484,-0.04614012,0.030168528,0.035053812,-0.04193918,0.001071469,0.020494383,-0.03624536,0.0057574594,-0.021180313,0.026385205,0.040008914,-0.070591144,0.024234328,0.059409328,0.12113752,-0.021454686,0.036102485,-0.029658347,0.038477737,-0.008100563,-0.04530659,-0.13587007,0.039605502,-0.03139655,-0.020439738,0.0025476976,0.016072854,0.04297606,-0.010531383,0.0006609953,0.024624461,-0.07242546,0.03267497,0.028640214,-0.027437644,0.019290688,0.04412381,0.045352384,-0.0103438925,-0.042102333,0.022592314,-0.031101756,-0.0020250198,-0.02509971,-0.05616281,-0.0049276943,-0.030233383,0.03971621,0.049530067,0.09761448,-0.0093415 +5.3.3.23,"The enzyme, characterized from the bacterium Rhodospirillum rubrum, participates in methionine salvage from S-methyl-5'-thioadenosine. It is a RuBisCO-like protein (RLP) that is not capable of carbon fixation, and catalyses an isomerization reaction that converts S-methyl-5-thio-D-ribulose 1-phosphate to a 3:1 mixture of S-methyl-1-thioxylulose 5-phosphate and S-methyl-1-thioribulose 5-phosphate. The reaction is an overall 1,3-proton transfer, which likely consists of two 1,2-proton transfer events.",384,0.99999994,-0.09422709,-0.06464284,-0.08707742,0.024959471,0.05736645,0.04680368,-0.038598645,0.08691263,1.8689221e-05,0.01729319,0.003912272,-0.015330735,-0.016993463,0.021102188,-0.025842689,-0.026531305,-0.02060602,0.028362071,-0.021359175,-0.024211323,0.06402073,0.031057974,-0.052393764,-0.026551677,0.07259904,0.027157383,0.015956612,-0.035293195,-0.076521374,-0.06877057,-0.008087601,-0.059126224,0.05829861,-0.07285672,0.07875057,0.15443541,-0.056015234,-0.024695626,0.11279973,0.01807004,0.03365951,-0.025806244,0.084325746,-0.0055127293,-0.06562424,0.030240195,-0.021761734,0.0877633,0.07970666,-0.068572946,-0.102584295,-0.061263476,-0.05061054,0.005302995,0.04363112,0.04705148,0.049336754,-0.05634261,-0.0301167,-0.034664996,0.0072370525,-0.025896715,-0.010787597,0.020963911,0.05267801,-0.10634827,0.020550573,-0.050025947,0.0901326,-0.004149172,-0.013901194,-0.006310495,-0.04453652,0.008883586,0.005388102,-0.061498355,-0.014506262,0.008737856,0.053493794,-0.017538678,0.0028111788,-0.01704369,-0.0035881025,-0.007546633,0.022038251,0.03981525,0.022058351,-0.021703638,0.03284047,0.010053621,0.0005702597,0.031022545,0.011483826,-0.103548974,-0.11371028,-0.011958975,-0.022496605,0.053107277,0.007672231,-0.009438596,0.044592187,0.07214843,-0.040342398,-0.12061723,-0.04589665,-0.015036331,-0.03930726,0.077959724,-0.008615144,0.011283248,0.050454177,0.015830383,0.009007782,0.029482694,0.013887194,0.12558737,0.062059805,-0.055606026,-0.117185734,-0.05113855,0.010949286,-0.0775823,0.05844163,0.022472396,-0.061145782,-0.014830414,-0.08268827,8.262713e-34,0.09572625,0.03676027,-0.094453275,-0.01347722,-0.011355509,0.037271276,-0.10933768,0.0026736597,0.00180704,-0.010276395,-0.052830663,-0.06696186,0.051079694,0.0051164217,-0.102350116,-0.005345152,-0.065099,0.058617532,0.047410104,0.0060769655,0.0010072024,0.030624097,-0.015226339,0.033683337,0.024068555,0.09655127,0.009909907,-0.007961569,0.06886741,-0.02168741,0.053610675,0.0012693228,-0.09269067,0.055370193,0.013070491,-0.016181815,-0.062021814,-0.053594682,0.05490294,0.042475495,0.018377595,0.02509531,-0.05983554,-0.0013590303,0.094617575,-0.029736666,-0.034358054,0.01935935,0.0055589606,0.055225518,-0.003045893,-0.07115234,0.17111349,-0.055633485,-0.08366498,-0.06459157,0.031906057,-0.012660846,-0.018757382,0.08135123,0.03919294,0.05899804,0.021362996,0.014927648,0.0384184,0.018090965,-0.035029367,-0.038267516,0.08526295,0.09579242,-0.007872127,-0.0052300226,0.042103857,0.0062783505,-0.026249742,-0.064330526,-0.076747544,0.030104846,-0.011877919,0.049978916,-0.014743238,-0.013850871,0.06867355,-0.030899702,0.0026186358,0.013531763,0.0052968115,-0.07655975,-0.0393069,0.005429547,0.082301535,-0.08245888,-0.059219845,0.054271422,0.021705678,-7.047828e-34,0.07318728,-0.058017027,0.048847638,0.0018714148,-0.09832637,-0.021352602,0.012978171,0.025108583,0.025182303,-0.061376497,0.06427944,-0.0389282,0.028343389,-0.065876275,0.04217033,-0.048769277,0.0033024773,0.028263105,-0.04664938,0.020288514,0.021941364,0.0059118723,0.019085776,0.042485077,0.07948287,0.019810783,0.004801151,-0.018253686,0.04090193,0.003241415,0.07864832,-0.009100226,-0.065102175,-0.03679517,-0.046679266,0.053442784,-0.04570439,0.044336412,0.03428791,0.033838946,0.05143753,0.064090766,0.012961438,0.040487744,0.0048707332,0.030081999,-0.111398846,0.041095167,-0.028822253,-0.08470088,0.045745526,-0.0667572,-0.007001015,-0.005425526,0.017533373,0.078432575,0.011276532,0.06495333,-0.01802651,-0.051390443,-0.084796354,-0.08696131,-0.013722949,-0.02096689,0.048635215,0.11648555,0.06481421,0.017436605,0.049660496,0.00042666632,0.07968513,0.056705046,0.05446789,-0.0075769112,-0.011292099,-0.028462658,-0.069949724,0.025812926,-0.004045604,-0.033127286,-0.03249962,-0.025529772,-0.027616534,-0.029188061,0.027691174,-0.081697516,0.030696029,0.08819604,0.004011518,0.023979107,-0.07149174,0.018538292,0.036563396,0.002332201,0.0736063,-4.4809266e-08,0.08791162,-0.058936782,-0.0039510434,0.002747664,0.06041299,0.07681295,-0.015151723,-0.019486714,0.03424468,0.021472182,-0.06149009,0.10787323,0.01993671,-0.031825997,0.025813561,0.06699328,-0.063624844,0.024536746,-0.0103212865,0.020755842,-0.019300237,-0.050904214,-0.10605115,0.035756867,-0.011802371,-0.03043567,0.07609013,0.05346853,-0.029918076,-0.10923562,0.03005617,-0.002586403,0.0056162192,0.040752117,-0.030534383,0.014086281,-0.014465198,-0.010102524,-0.0073548835,0.0043124165,-0.004244403,0.037985712,-0.11006914,0.045808036,-0.06455228,-0.047280762,-0.03750995,0.021045335,-0.041446082,0.023816515,0.027527679,0.034061655,0.0039752787,-0.08223978,-0.07425247,0.0050125904,0.008180477,-0.029039305,-0.037373304,0.07738974,0.041384287,-0.02361957,0.13223821,-0.03963268 +6.2.1.66,"The adenylation domain of the enzyme catalyses the activation of glycine to (glycyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein (as in the case of DhbF in bacillibactin biosynthesis), or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0,-0.015210121,-0.079186864,-0.09363192,-0.07047848,-0.026662385,0.005391158,-0.042281814,0.033348057,0.10991787,-0.012755841,0.015921976,0.05285794,0.048854224,0.045323342,0.016215011,-0.019037902,-0.045000978,0.01618692,-0.020987822,-0.07432699,0.05578203,0.031219848,-0.0072841225,0.017429017,-0.0385016,-0.019629188,0.02757596,0.015375053,0.01177079,-0.026173417,-0.017743876,-0.021422742,-0.021455986,-0.023876384,0.030986147,0.12251963,-0.025224915,-0.015037579,0.07190059,-0.036236025,0.06076259,-0.054408077,-0.011832073,0.0066452553,-0.035055898,0.0621094,0.016228765,0.084816135,0.049863137,-0.053151798,-0.005269632,-0.047809806,-0.06505964,-0.023267323,-0.009431529,0.08998952,-0.073613696,0.017541816,0.04830253,-0.024890201,-0.08678574,0.005654059,0.032871142,0.04292095,-0.0005125925,-0.109899685,0.006735083,-0.01686768,-0.056899153,0.0024511886,-0.0026986029,-0.07982373,-0.012353017,0.039039772,0.049525313,0.012333641,-0.07023903,0.027408123,-0.02525405,-0.0463967,0.06589808,-0.022487441,0.062298805,0.077321045,-0.01165294,0.01344654,0.021772295,-0.038560968,-0.009412626,-0.00805806,0.06354632,-0.08276914,0.055572487,-0.022787143,-0.053040598,-0.05934906,0.046172973,-0.034411725,-0.05080199,0.0012583189,-0.015369152,0.023173776,-0.018724762,-0.025267616,-0.010668944,0.03935229,-0.032739263,0.09627592,0.021784581,-0.0014170991,-0.050560866,0.06464861,0.049856182,-0.05585029,-0.0056250533,0.060395706,-0.021651402,-0.016076367,0.023840949,-0.10302707,-0.014436285,-0.023199424,0.03316593,0.08680522,-0.07057593,0.017208876,-0.053138316,2.766484e-33,0.072537474,0.0145355305,0.078490965,-0.029141735,-0.05750636,0.013403311,-0.06382407,-0.002612895,0.05265904,-0.030723102,-0.06261708,-0.018844754,0.010065048,0.0067207697,0.012223954,-0.015270004,-0.08249114,0.053201277,0.075099535,0.07010277,-0.030880118,0.032364767,-0.010609078,0.050218575,0.06707903,0.043828998,-0.034482744,-0.04270639,0.014787695,0.020599738,-0.06648431,-0.04325438,-0.11049103,-0.008380883,-0.017423257,-0.022414405,-0.008599633,-0.06317649,0.07091529,0.033178717,-0.047219817,-0.10185713,-0.022147376,-0.03705346,0.010605448,0.065699145,0.009290413,0.06539729,-0.090015024,0.038388815,0.064998694,-0.07215723,0.10970379,-0.050181028,-0.052478507,0.04296573,-0.001496189,-0.0695207,-0.02330038,0.077164054,0.04870622,0.043226283,-0.022262763,-0.026399292,-0.04431762,0.023935735,-0.0793725,-0.11578344,0.018133936,0.11942645,-0.00037317706,0.08643158,0.09468181,0.050313484,-0.0013575535,-0.027332604,-0.03977043,0.019189905,-0.008271747,0.052148096,-0.009824645,0.043117825,-0.05690042,0.0044062086,0.03936247,-0.019220978,0.016432364,-0.092296645,-0.09859416,0.01819975,0.026741557,-0.014775329,-0.04265346,0.08097323,-0.009840496,-4.2807585e-33,0.107539274,-0.1464124,0.027038058,-0.021807779,-0.072018385,-0.02524267,0.0148518905,-0.02552971,0.03304036,-0.026251618,-0.015225283,-0.0019099126,-0.06906609,-0.05142192,0.001575665,-0.025657933,-0.062233977,0.008583775,-0.0849672,-0.012907626,-0.040922023,-0.0002150273,-0.0006151393,0.026740743,0.03218135,0.009652906,-0.08024753,0.093835,0.026949462,0.041689362,-0.03683435,-0.0011881351,-0.07960297,0.0036055294,-0.056572903,0.09926132,-0.04205173,0.052648943,0.021382311,-0.039282467,0.0034439631,0.07631758,-0.01457279,0.06763569,0.045256093,0.11819439,-0.0020278092,0.05868807,0.040446047,-0.06536321,0.012938997,-0.01244651,0.08382142,0.03687761,-0.010422368,0.0782792,0.04501788,0.025651831,0.018557409,-0.017199682,-0.036008295,-0.07365738,0.0028667466,0.05201463,-0.025722735,0.05561398,-0.016721131,0.034665,0.07571426,0.05038208,0.025879392,-0.041340686,0.038234383,0.025640242,0.029338555,0.0509253,-0.041810557,-0.09260654,-0.07561209,-0.05412861,-0.038767878,0.008884611,-0.03443395,-0.031493276,0.0059286114,0.021179171,0.06676327,0.12018785,-0.003534131,0.03099901,-0.011363119,0.036575258,0.024073223,0.0417308,0.014593835,-4.041931e-08,0.012301933,-0.039940413,0.021970838,-0.107402764,0.018359242,0.07461619,-0.027983962,-0.03798793,0.031099392,-0.04833811,-0.107987456,0.0379523,-0.064511575,0.029611148,-0.021371484,0.15234618,-0.043104768,0.02642513,0.022295909,-0.05413105,-0.080088295,0.044234045,-0.11359138,0.055353057,-0.016476281,-0.029964926,0.04929686,0.010134114,-0.005363743,0.03272586,0.075700976,0.035582624,-0.044131305,-0.03941482,0.012368852,-0.00452909,-0.018550007,0.0035402928,0.0039547905,-0.03428839,-0.036863543,0.0066610333,-0.030384155,0.0035997282,0.029139709,0.0507705,0.026735224,0.0570694,0.004790857,-0.017230235,0.0011137315,0.017960733,-0.009642244,-0.08245908,-0.09798066,0.015557923,-0.06869536,-0.11785851,0.03829731,-0.04827631,-0.056634083,0.010787425,0.1964887,-0.002514116 +6.2.1.67,"The adenylation domain of the enzyme catalyses the activation of L-alanine to (L-alanyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0,0.013948889,-0.09149871,-0.06663743,-0.06824024,0.022693384,0.053910933,0.0034224233,0.027771147,0.1379415,0.047769934,0.026415953,0.011162813,0.039301638,0.03767367,0.066967286,0.031225486,-0.11585967,-0.028524632,-0.030484771,-0.07926354,0.057010558,0.050318476,-0.02049261,0.040922325,-0.0014577572,-0.0055734627,0.037146766,0.019566612,0.025987325,-0.018437833,-0.0178163,-0.04093606,0.0063212854,-0.0055836244,0.025883358,0.08480213,-0.043706555,-0.04828096,0.029959299,-0.010133417,0.046354994,-0.04974977,-0.012368751,-0.026791098,-0.05548408,0.03716122,-0.022696506,0.11696263,0.039327607,-0.005007694,0.017655158,-0.09651555,-0.03625072,-0.050604433,-0.099472836,0.13466235,-0.07976974,0.0135979885,0.010088714,0.004020269,-0.055596147,0.026806438,-0.013950485,0.013843262,0.008735767,-0.09368253,-0.015794015,-0.013102986,-0.010502066,0.00020312773,-0.0013529513,-0.09961505,-0.019550443,0.061715644,0.09710145,-0.0429433,-0.034433678,0.014263765,-0.05618882,-0.033346012,0.07294317,0.0036299173,0.024329402,0.049222782,-0.0076495428,0.019331476,0.024542134,-0.03634232,0.027124815,-0.028882764,0.045518156,-0.12112047,0.05892165,-0.018277984,-0.028988441,-0.019554446,0.029124817,-0.041976277,-0.025059784,0.0061404854,-0.0036223165,0.029504238,-0.062257815,-0.033148315,-0.022306522,0.03561028,-0.04695827,0.103709444,-0.024460746,-0.065373965,0.038556866,0.034708664,0.07564138,-0.012010027,0.017408323,0.057024647,-0.014966137,-0.08518974,0.02054827,-0.07673667,-0.022513898,-0.03695921,0.030344792,0.09404192,-0.03774742,0.024478626,-0.083484076,1.8138212e-33,0.06311551,0.01358589,0.07028177,-0.0035284667,-0.075169176,0.023050327,-0.034303553,0.01127246,0.070096426,-0.015359465,-0.07011368,-0.027242249,0.023027461,-0.04142041,0.026559364,0.00040763407,-0.05910654,0.10633161,0.06280138,0.097375855,-0.07314142,0.06319619,-0.0023090302,0.03980186,0.022788925,0.05949513,-0.028246528,-0.09181478,0.06398774,0.010859162,-0.06885796,0.01892558,-0.07332069,0.02501917,-0.03811564,-0.006615532,-0.019763768,-0.03809762,0.061048888,0.035559878,-0.027219389,-0.057687733,-0.017619407,-0.03501099,0.0056735547,-0.03235118,0.011518339,0.04805112,-0.08303909,0.04054777,0.07154291,-0.024463497,0.11083828,-0.05069658,-0.059010934,0.020568559,-0.047245514,-0.03944935,-0.0064591747,0.056724437,0.08102046,0.015942886,-0.013383812,0.013118385,-0.055340886,-0.0024475781,-0.03570703,-0.15769573,0.011688012,0.16511096,-0.02342612,0.06540601,0.08535095,0.045485318,0.03468524,-0.02581616,-0.09285657,0.04657765,-0.032342203,0.056332085,0.008067853,0.028515987,-0.049781878,0.021368906,0.024805866,-0.05383293,0.071148805,-0.08791118,-0.07197522,0.0006149645,-0.0016743073,-0.0087968465,-0.032442693,0.103684224,0.0261282,-2.9704263e-33,0.08254092,-0.16473965,0.011662528,-0.032880757,-0.08344459,-0.0025848902,0.034896787,-0.029922014,0.012546303,0.0061092107,0.02982369,0.019010048,-0.07422483,-0.07133186,0.051019672,-0.080551125,-0.013902928,-0.0009556059,-0.04109649,0.011293158,-0.04243106,-0.016470792,0.03680908,0.053515892,0.039616067,-0.03371012,-0.06891418,0.069961056,0.042267445,0.006532154,-0.026070263,-0.036384698,-0.02819708,0.000989553,-0.068719074,0.090718605,-0.014762631,0.03566319,0.040427092,0.011516,0.010108826,0.041383494,0.013526244,0.055597685,0.006133433,0.072409585,-0.038777698,0.030243019,0.027832553,-0.08714586,0.026956914,-0.05845679,0.080003366,-0.015057599,-0.0012471363,0.06913917,0.0060861968,0.04094452,0.006995286,-0.009568063,-0.06541172,-0.06287946,-0.039069224,0.043191656,-0.023957133,0.01847197,-0.025238656,0.04410644,0.040038202,0.044252068,0.054624833,0.007316289,0.06099123,0.02659191,0.025562048,-0.016992243,-0.01982598,-0.12528403,-0.044025954,-0.10628835,-0.057141867,-0.028822616,-0.007815786,-0.030244492,0.00563706,0.037630726,0.049701978,0.09935848,-0.018991744,0.059999842,0.01038747,-0.0069657587,0.015461653,0.014316653,0.02347024,-3.8513054e-08,0.029347796,-0.032911226,-0.01898747,-0.08053163,-0.023674803,0.05868157,-0.0049479827,-0.03289452,0.0052637164,-0.017169546,-0.06259448,0.027919888,-0.043426596,0.058603186,-0.0048121247,0.09420713,-0.02137299,0.05682034,0.0058180685,-0.057861127,-0.07541772,0.05174502,-0.059591953,0.009112019,0.010004714,-0.005160492,0.06539132,0.027860604,0.014884843,0.024746643,0.06928538,-0.0051671984,-0.022542223,-0.01214847,0.014841414,-0.00035424228,-0.0043503563,0.0031070178,-0.0403968,-0.022041803,-0.018930903,0.02724417,-0.06971283,-0.011502131,0.01914831,0.045022566,0.029365906,0.039394636,0.017153168,0.0008460209,0.017851504,-0.0055309357,-0.0044989586,-0.06220618,-0.07386349,-0.026494477,-0.060469225,-0.13657936,0.07559946,-0.061856993,-0.01380143,0.05280996,0.18734753,-0.025417168 +6.2.1.68,"The adenylation domain of the enzyme catalyses the activation of L-glutamate to (L-glutamyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0,-0.002721976,-0.088326536,-0.046069514,-0.0687394,-0.020998172,0.02486794,0.00807664,0.044223893,0.121053055,0.03564643,0.053656574,-0.021257237,0.06902753,0.053081166,0.060049143,-0.0110651115,-0.097174674,-0.039093297,-0.021458177,-0.08231089,0.059685998,0.08236612,-0.029147599,0.01165921,-0.010990663,0.017955786,0.048033476,-0.0005664615,0.03479295,-0.027818134,-0.022511173,-0.026675018,0.008706797,0.014007502,0.041480124,0.087523945,-0.06617154,-0.058907043,0.07972685,-0.040052913,0.03002484,-0.0058231507,-0.004283985,-0.030619197,-0.03213348,0.037753183,0.018470284,0.10257321,0.027822426,-0.031232936,0.04777922,-0.074848324,-0.03866207,-0.025067598,-0.06329039,0.12293534,-0.0679659,0.0015884048,0.017838031,0.02791502,-0.07874397,0.024939718,-0.009430636,-0.0017779329,0.036743302,-0.10055807,0.025509305,-0.006898699,-0.004842423,-0.018824562,-0.00581265,-0.089530066,0.03160306,0.04872687,0.074241586,-0.041614976,-0.006106132,0.023175683,-0.04953332,-0.04389093,0.09563181,-0.006614738,0.054860543,0.049217958,0.0012093721,0.008190873,0.0017297588,-0.02635048,0.028812185,-0.017205305,0.058605548,-0.113320306,0.015816389,-0.038174298,-0.061660737,-0.028741077,0.013570559,-0.04868877,-0.024155302,0.0062908605,0.010901803,0.033773333,-0.027851135,-0.031869743,0.00978357,0.055849336,-0.011933676,0.095878914,-0.029439108,-0.042895988,0.010103784,0.056050662,0.056318946,-0.030428894,-0.02116457,0.044365425,-0.019508695,-0.06875148,-0.012232836,-0.07643134,-0.038671933,-0.0353469,0.007583057,0.06930804,-0.0741932,0.0038440288,-0.08216312,2.541791e-33,0.047088657,0.002543102,0.048717964,-0.03590696,-0.04878602,0.028586123,-0.05120095,-0.0028757816,0.08420976,-0.031980753,-0.08938845,-0.031089125,-0.0040415754,-0.026994867,0.032829996,-0.0029132448,-0.115283154,0.07605928,0.06547334,0.056232046,-0.05601832,0.055402007,-0.0034527048,0.023517001,0.031068929,0.07285246,-0.040892713,-0.06872589,0.050104562,0.010428976,-0.05854437,-0.009430106,-0.08696617,0.015684433,-0.01791223,-0.0055085015,-0.010995532,-0.050069056,0.060960855,0.03477312,-0.056488693,-0.048128825,-0.04412528,-0.023190485,0.0058723586,-0.02598736,-0.004149694,0.06073813,-0.09364245,0.068110734,0.06161433,-0.067267425,0.109459795,-0.057701297,-0.06358837,0.0350901,-0.029255068,-0.08817798,0.026316026,0.058856744,0.06333246,0.023783624,-0.05088014,-0.01040118,-0.034686033,0.026951723,-0.04430758,-0.15697838,0.032927755,0.15689683,-0.02124157,0.052492987,0.06672034,0.05535971,0.0045881295,-0.03251873,-0.07893057,0.0437411,-0.019684356,0.06366001,0.016722942,0.021214409,-0.030481787,0.025927361,0.041518375,-0.05227711,0.069286846,-0.09409469,-0.09052699,0.014639648,-0.0030333584,0.002365384,-0.0148588,0.092588246,0.011265532,-3.5915e-33,0.10605355,-0.13207315,0.012811044,-0.040936567,-0.0672378,-0.006084099,0.011672562,-0.041124746,0.0024805425,0.0075186174,-0.0077693975,0.037252318,-0.05928159,-0.05555819,0.041527808,-0.042661358,-0.04540664,0.02739463,-0.07339301,0.007594932,-0.018819936,-0.0037395807,0.024285194,0.07370149,0.04064988,-0.025008354,-0.061934184,0.06070503,0.037447687,0.025922209,-0.04657531,-0.043423906,-0.03333861,-0.01190308,-0.025290763,0.06940574,-0.006011532,0.053381905,0.01870383,0.014219434,0.025671346,0.0978649,0.019518105,0.052092254,0.0055268826,0.111148715,-0.024559623,0.040716145,-0.004366471,-0.08775805,0.05524542,-0.044803634,0.078050874,-0.047637198,0.005614259,0.04233329,0.040290784,0.0026737247,0.0077773384,-0.014918775,-0.06881945,-0.10059445,-0.03832618,0.025146844,-0.008506337,0.015219215,0.021152876,0.040958825,0.04670571,0.049580455,0.03687507,-0.023975963,0.05746046,0.0012900245,-0.00796347,0.0025703786,-0.04332176,-0.11045305,-0.007949986,-0.10946412,-0.0042626085,-0.023798918,0.0065856203,-0.027029611,0.014308773,0.01372504,0.033121824,0.114034355,0.019509602,0.060428012,-0.017651655,0.014937519,0.046470005,0.018945048,0.03624231,-4.0631246e-08,0.015921867,-0.03371492,-0.02029529,-0.057533924,-0.001029076,0.07989707,-0.039754506,-0.05896114,0.040219124,-0.025246,-0.03200222,0.05500384,-0.07858947,0.04910921,-0.035966847,0.095712595,-0.03117696,0.055486225,0.0034658366,-0.053842403,-0.08651876,0.05369036,-0.0846045,0.019351497,0.038585387,-0.013542108,0.052020285,0.0354366,-0.00031690006,0.02784209,0.06984477,0.008973023,-0.036303297,-0.03586963,-0.0015632353,-0.020053435,0.02819518,-0.00021404705,-0.044338267,-0.009809443,-0.023982413,0.046392344,-0.038933855,-0.007628189,0.00070226396,0.06543175,0.04872627,0.042145267,0.01614788,-0.0036163258,0.026452849,-0.020498002,-0.009508486,-0.059534688,-0.1184523,-0.030186594,-0.07465576,-0.12250764,0.0454648,-0.081183545,0.009104862,0.06378328,0.18140706,0.0062680026 +6.3.1.21,"Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme requires ATP and utilizes formate, which is provided by the hydrolysis of 10-formyltetrahydrofolate by EC 3.5.1.10, formyltetrahydrofolate deformylase. The other enzyme, EC 2.1.2.2, phosphoribosylglycinamide formyltransferase 1, utilizes 10-formyltetrahydrofolate directly. Formyl phosphate is formed during catalysis as an intermediate. The enzyme from the bacterium Escherichia coli can also catalyse the activity of EC 2.7.2.1, acetate kinase.",384,1.0,-0.07853484,-0.05345497,-0.099318944,-0.065608405,0.007262835,0.029622678,-0.08890792,0.014678229,-0.012317546,0.003535351,0.03473311,-0.07535149,-0.080922574,0.0076226285,0.012690934,-0.012672297,-0.14841433,0.03365752,0.065667965,-0.07911455,0.11127522,-0.02636782,-0.059648357,0.008811185,0.046396375,0.03287294,0.08833949,0.016762424,-0.012086353,-0.09552776,-0.022359645,-0.12026515,0.046816234,-0.05400194,0.08609329,0.07459849,-0.0843157,-0.07380846,0.05222203,0.009012638,-0.009893874,-0.03469251,-0.010238913,-0.031137882,-0.008402215,-0.020730423,0.056429766,0.051258117,-0.0010222222,-0.076393954,-0.07063305,-0.019580496,-0.010029549,-0.047070466,0.029538454,-0.031633176,-0.06076138,0.011458066,-0.012338599,-0.01376244,-0.005217336,-0.012422705,-0.032740653,0.011639095,-0.021588705,-0.053491022,0.069017805,-0.09662016,0.0032223999,-0.004025573,-0.09057295,-0.07488652,0.018210715,0.039476503,-0.0066587664,0.015017891,-0.036970306,-0.009622275,0.0028354626,-0.0076057264,0.026320836,-0.042241044,-0.019704908,0.034500655,0.013451954,-0.030170057,-0.010424619,-0.003102454,0.008993837,0.021624545,0.057075065,-0.02377318,0.052771784,-0.03959319,0.0024311875,0.11224805,0.0055351197,0.07080402,0.086977415,-0.049345013,-0.01734732,0.12185245,-0.050458886,-0.041108534,0.06064402,0.019084504,0.022260841,0.12316366,0.029947577,0.027708504,-0.029713167,-0.048899632,0.0242496,0.025144845,0.01044313,0.13630928,0.029227758,-0.10769498,-0.004860866,0.027733022,0.02569674,-0.08297912,0.028623879,0.055172443,-0.054996047,0.055652436,-0.0929633,5.4230738e-33,0.05407869,0.06583768,0.004746033,-0.018202111,-0.018629331,0.0031455096,-0.10962223,0.021760855,-0.012639345,-0.06891843,-0.040241487,-0.06142156,0.0742999,0.0017737891,-0.025346475,-0.09098405,-0.025405606,0.06442009,0.03629099,0.063070916,0.039125733,0.004512866,0.004693381,0.0058446997,0.027205009,0.056686338,-0.014759068,0.03328088,0.0058452436,0.0021363432,-0.011595741,-0.108460724,-0.06910942,0.027767755,0.053728838,-0.079210185,-0.01586013,-0.027474247,0.039434243,0.07086083,0.01055701,0.0072760265,0.008714296,-0.029686157,0.030926982,-0.021474294,-0.022443801,0.078357406,0.050729316,0.05679631,0.040968515,0.027646264,0.11837385,-0.025640048,0.016222274,0.019620895,-0.024176335,-0.05332766,0.065893024,0.042436637,-0.008629655,0.0905063,-0.004120159,0.024186593,-0.022215893,-0.013391008,-0.08256456,-0.016323347,0.016742846,0.103792146,-0.035668775,0.0044944175,0.065303974,-0.038941275,0.08393165,-0.024595851,-0.026535258,0.011912302,-0.012364438,0.023249742,-0.020332625,0.037468974,0.015114184,0.04083018,0.01278572,-0.0067487103,-0.043837402,-0.03280959,-0.023120522,0.07654963,-0.032837797,-0.062469408,-0.07506234,-0.0011624416,0.041920025,-5.675741e-33,0.090656966,-0.053475704,0.025779717,-0.1295836,-0.07784339,0.08469044,0.06569861,-0.033639416,0.09581347,0.025580369,0.022241125,0.022386003,0.06813978,-0.0951394,-0.004793607,-0.00066576083,-0.028039282,0.08319689,0.013412581,0.003308679,0.057923127,0.08288058,-0.05757658,0.045904364,0.066411115,0.0107678315,-0.030993529,0.09613082,0.02760041,-0.0016530395,-0.023958493,-0.046602704,-0.004527566,-0.008944162,-0.07153029,0.053345878,-0.09175547,0.050946407,0.00028506757,-0.025028089,0.012062953,0.052306466,-0.009087576,0.02570836,0.04768879,0.057303984,-0.020956252,0.04428506,-0.003775187,-0.08078788,0.026672808,0.004277006,-0.025916252,0.035539072,0.024361083,0.018902408,0.001428103,0.05017163,-0.002630259,0.0152661335,-0.030331617,-0.06166539,0.07269248,-0.023927918,0.055953845,-0.036042884,-0.06244203,0.057054877,0.0134988185,0.021823863,0.030760745,0.00078081933,0.0060582473,0.03732636,0.022826826,0.028575499,-0.064509936,-0.036504224,0.0111295385,-0.021194307,0.013535917,0.006178026,-0.04086628,-0.05956415,-0.018957496,-0.00037576194,0.05832491,0.03739842,-0.044277605,0.028239682,-0.036311302,-0.026420025,-0.010934533,0.08437752,0.009022312,-4.308113e-08,0.038899153,-0.0722487,0.08672681,-0.08250182,0.048780918,0.049552232,-0.005633209,0.029634897,0.08238333,-0.10753016,-0.015182301,0.023400791,0.10687505,0.029220356,0.030483684,0.03092145,-0.02586866,0.0055828094,-0.040837694,-0.02063293,-0.072128594,-0.04343305,-0.12402609,0.06593775,0.04529587,-0.019457828,0.0254819,0.04668543,-0.03680023,-0.006918514,-0.011777787,0.012275787,-0.010297401,-0.021145055,-0.05664045,-0.015545482,-0.04123141,-0.040830586,-0.03773052,0.04892263,0.0037498819,-0.047066342,-0.081485614,0.045511384,-0.026818216,0.034825064,-0.013875302,-0.0031434672,-0.03788274,-0.028653149,0.02441183,-0.014653588,-0.020437783,-0.08149625,-0.055891357,-0.0066034915,-0.04356347,-0.093585365,0.024721306,-0.0148319695,0.06511982,0.037695076,0.22768983,0.011795532 +6.3.2.59,"The enzyme participates in the biosynthesis of L-pyrrolysine, a naturally occurring, genetically coded amino acid found in some methanogenic archaea and a few bacterial species. L-pyrrolysine is present in several methyltransferases that are involved in methyl transfer from methylated amine compounds to coenzyme M.",384,1.0,-0.024892533,-0.070564725,-0.0912976,-0.054905254,0.10186703,0.09161978,-0.079432786,0.021569546,0.034150947,-0.008613672,0.005073328,-0.05316279,-0.05836197,-0.031317815,-0.034689955,0.07851961,-0.12554845,-0.048559636,0.02368095,-0.0366949,0.083742365,0.0861919,-0.039564718,0.020881271,-0.0004227247,0.010088454,0.055143245,-0.009428519,0.023224806,0.019478627,-0.012050554,-0.02713131,0.010391371,-0.029282639,0.07150732,0.104458146,-0.062095165,-0.029767176,0.06763685,0.010406804,0.041810717,-0.009616159,0.055628132,-0.013156887,-0.09739523,0.016119292,0.067127936,-0.012931767,-0.07063577,-0.0534575,-0.014690873,-0.04526797,-0.035367873,0.045959007,-0.024628883,0.032942463,0.025669878,-0.030441193,-0.016735584,-0.039325934,0.009342623,0.050363954,-0.023665696,-0.04426783,0.00046277986,-0.006836648,0.0621474,-0.04117259,0.096093856,-0.122296296,-0.07082575,-0.06788662,-0.03130383,0.03495188,-0.014434453,-0.027264202,0.0008646562,-0.013065176,0.0066344393,-0.04675528,0.010048524,-0.01366264,-0.042574972,0.022700993,0.032160174,-0.05100861,-0.046449907,0.07303821,0.071811296,-0.015384541,0.023844292,-0.04847181,0.0011427165,-0.0074599204,-0.12153436,0.037352685,0.05114757,0.023488019,0.04294431,-0.052593384,0.004912475,0.06953564,-0.112483546,0.0076802527,-0.07590826,-0.038226943,0.048774816,0.09451716,-0.019768888,-0.020039113,0.013914337,0.046958018,0.06926839,0.04638889,-0.026086383,0.032354306,0.08178871,-0.068263136,-0.037711952,0.028911185,-0.004541634,0.025123648,0.11022514,0.074620806,-0.0025443728,0.0121172,-0.12240962,3.4109746e-33,0.067191206,0.020415455,0.0031518727,0.023679024,0.041059274,-0.009406977,-0.052327074,-0.00091454334,0.024318423,-0.08232525,-0.08507883,-0.13025893,0.026052922,0.04216575,-0.076198675,0.013908558,-0.030571679,-0.021992397,0.06884931,0.015007267,-0.06332305,0.09917362,0.007428478,0.035065584,0.011341835,0.04670146,0.025484093,0.018731082,0.0469515,-0.009708895,-0.006290455,-0.1298067,-0.08533161,-0.04675264,0.08373352,0.026194207,-0.059685938,-0.038448807,0.023953654,0.06882441,0.024814032,-0.019549606,-0.01721185,-0.0034850717,0.026707254,0.00559716,-0.058009807,0.10304777,0.0053361813,0.031940024,0.040313825,-0.04011647,0.020954374,-0.060366057,-0.10226211,0.016259588,-0.05604014,-0.06564199,-0.016775278,0.06558486,0.03448851,0.042054806,0.016130067,0.06834533,0.01442337,-0.06327478,0.0052650766,-0.023894964,0.043944817,0.07030715,-0.07324324,-0.07910882,0.07358285,0.06745244,0.051802527,-0.034108113,-0.10159108,-0.02864002,0.027260717,0.0032981117,0.009505876,-0.003923912,0.0030939097,-0.023639984,-0.013094766,-0.050605763,-0.00030393637,-0.13522768,0.03330054,0.011782313,-0.034750942,-0.10084438,-0.017908605,0.04222256,0.0007787104,-4.8311224e-33,-0.00067277404,-0.050157867,0.057127748,-0.10478943,-0.064767,0.0043862937,0.02373539,-0.020171307,-0.005323647,-0.016511358,0.07534577,-0.0060763652,-0.010084536,-0.05235617,0.05556202,-0.03820214,0.009234931,0.062136237,0.05393127,0.0009724676,0.047930688,-0.00043843707,-0.012942967,-0.007948042,0.025155172,0.010809867,-0.024225678,0.11119597,0.07424824,0.022186447,0.017614564,0.04839957,-0.013794363,-0.07379989,-0.05356992,0.058861736,-0.047606647,0.012175644,0.016331766,0.008369098,0.04518577,0.054725453,-0.0012170654,0.012532796,0.0037312184,0.028760144,-0.06639331,-0.08469153,0.026954796,-0.07252013,0.022435827,-0.034492515,0.032734796,-0.034461297,0.05692977,0.0065465826,-0.04011739,0.07229306,0.04536635,-0.01933601,-0.041399885,-0.06063495,-0.0082495045,0.020621505,0.03257408,0.022238206,0.0014610656,0.021545885,0.057362523,0.012126693,0.101280354,0.034143627,0.07048332,0.08451602,-0.09084206,-0.049441144,-0.08640517,-0.028781706,0.0059894924,-0.04080196,0.022398477,-0.050025336,0.07888802,-0.06403581,-0.06547447,-0.12580033,0.06375954,0.09683454,0.007809061,-0.0077211,-0.029278345,-0.017802207,-0.027450237,0.025999097,0.08421047,-3.643395e-08,0.0242563,-0.056849577,0.030785838,-0.010849953,-0.045131627,0.053700946,-0.0039712265,-0.0001582469,0.004698384,0.0015932211,-0.000719656,-0.030965393,0.012475561,0.023663996,0.005589734,0.08263217,-0.05370209,0.023938486,-0.015367777,0.031396475,-0.04611876,0.04818131,-0.047260147,0.011923988,0.02349392,-0.017805802,-0.008965946,0.10480065,0.01334944,-0.027014704,0.044996675,0.010427375,0.07968351,-0.037149977,-0.06522468,0.027132962,-0.037416723,-0.06091631,0.024870062,-0.005068692,-0.0054267813,0.019148918,-0.07079233,0.034591,0.058095872,-0.008468244,-0.04110475,0.07288696,-0.04306611,0.029333485,0.09416442,-0.02469706,0.024723796,-0.062322922,-0.08420697,-0.03736616,-0.0510846,-0.0342325,-0.0064292853,-0.07163179,-0.0053742197,0.045412667,0.15846166,-0.08005736 +6.3.2.60,"The enzyme, originally characterized from the archaeon Sulfolobus acidocaldarius, is involved in L-arginine biosynthesis. The enzyme from the archaeon Thermococcus kodakarensis is bifunctional and also catalyses the activity of EC 6.3.2.43, [amino-group carrier protein]---L-2-aminoadipate ligase.",384,1.0,-0.073194854,-0.10039312,-0.13497038,-0.027351037,0.040361483,0.088184685,-0.075404614,0.03904368,0.036567166,-0.012174049,0.044921663,-0.03364727,-0.053956628,0.030174103,-0.059412695,0.03425115,-0.15507908,-0.038647525,0.013351795,-0.031152789,0.06882386,0.040206406,-0.0723008,-0.014046488,0.054034777,-0.03736417,0.030077903,-0.077771924,-0.016288439,-0.014533917,0.010718042,-0.073801875,0.061130583,-0.03393865,0.07187923,0.0677594,-0.03539591,-0.11036723,0.06807394,0.026042266,0.0564309,-0.008569859,0.00023972144,-0.08016796,-0.030856334,0.024429882,0.039367784,0.008229792,-0.00085952634,0.0124961855,-0.015213166,-0.049189337,-0.027185697,-0.017653262,-0.033118516,0.07746167,-0.10128816,-0.028744282,0.029735968,-0.0076633594,0.045625284,0.09204144,-0.016361022,0.03266976,-0.03727541,-0.085993595,0.084775046,-0.050536044,0.057292253,-0.057314195,-0.050124712,-0.08326646,-0.04046757,0.05923589,0.012518339,0.051209092,0.0096667735,-0.07044319,0.048353415,-0.060848333,0.041792292,-0.034275077,-0.049511515,0.08104877,0.008064461,-0.043930553,0.052892823,0.0324212,0.07590784,0.008843447,0.04949622,-0.075561866,0.011199018,-0.09111985,-0.05801266,0.009281263,0.019141002,0.06905752,-0.032686025,-0.015664194,0.0010068235,0.09690322,-0.062330917,-0.11577449,0.0039224625,-0.006193975,-0.02335048,0.11040102,0.050758522,-0.01866917,0.00028887758,-0.03610031,0.016836995,-0.015149483,-0.029907063,0.08448666,0.03658515,-0.105650045,-0.08204223,0.022741534,-0.02314285,-0.009844065,0.06980509,0.06093966,-0.09443253,0.04883186,-0.09566692,1.1678559e-33,0.053132802,-0.0003685364,0.023201605,-0.060458813,0.035401795,-0.013499321,-0.11775008,0.031454414,0.0070554763,-0.061651736,-0.09899463,-0.02658262,0.064169794,0.037389107,-0.015077223,0.05796993,-0.019328827,0.005994739,0.018002281,0.05864832,-0.049549334,0.06367797,0.006465408,0.03394445,0.0705758,-0.017241467,0.040509973,-0.024500554,-0.0073641674,0.031490855,-0.02071489,-0.13046817,-0.10690593,0.008333335,0.055143584,-0.051795132,0.021499315,-0.06576827,0.00038870037,0.0045759906,0.024341166,0.0242892,-0.009302426,0.014601982,0.022593474,-0.020021304,-0.004803874,0.10080887,0.021838013,0.028760059,0.021980133,-0.042384833,0.08610654,-0.01880645,-0.027190937,-0.0015748941,-0.057342485,0.03256791,0.085851796,0.022987029,0.0066980654,0.066926464,0.02319767,0.07265951,-0.024302488,-0.0006928988,-0.04535054,-0.026755515,-0.0030359058,0.016397934,-0.095407076,-0.035417274,0.06520856,-0.01840889,0.004893587,-0.024430448,-0.058830395,-0.015893416,-0.0056676306,0.0018822993,-0.022502456,-0.0030221408,0.09987499,0.06313187,-0.0053193863,-0.06251199,0.020022556,0.026883647,-0.039830357,0.055988755,0.014569268,-0.02637488,-0.062148456,0.07763331,0.024176069,-2.1216931e-33,0.09212315,-0.106959045,0.0035223963,-0.13734892,-0.08340274,0.047182914,0.08356869,0.030111633,0.00668834,-0.036663625,0.081912205,0.010514096,0.0734644,-0.07782969,0.07382728,-0.03785816,0.022895902,0.035431586,0.040184204,0.031211484,0.008878863,-0.0005043328,-0.03280673,-0.014836133,0.012057295,0.011138084,0.00053881493,0.028559217,-0.015130745,0.0437379,-0.014853803,0.0018940292,0.008445253,-0.059161592,-0.057298698,0.05726256,0.04810317,0.0019005246,0.04296271,-0.041757595,0.020518418,0.034298528,-0.01595246,0.04269137,0.06248199,0.0009298217,0.027286498,-0.047082514,-0.029500514,-0.048340496,0.07276343,-0.069557674,0.056978736,0.011908946,-0.009200753,-0.01690853,-0.03130456,0.039485496,-0.036110826,0.018242432,-0.017565757,-0.054685675,0.03639374,-0.0022949022,0.0322565,0.048549328,-0.057093352,0.053244617,-0.03049024,-0.06671439,0.11623828,-0.005205969,0.019979471,0.096831396,0.008861345,-0.048549633,-0.03460158,-0.050660107,0.044841025,-0.033173468,-0.039297212,-0.022381619,0.025100728,-0.021152666,0.0018841671,-0.04646304,0.065662526,0.11156287,0.011473307,0.0030678613,-0.016360085,-0.03623264,-0.06923233,0.04349678,0.05973039,-3.9193026e-08,0.046837535,0.0037783268,0.057378337,-0.01379182,-0.003408108,0.029498251,0.011047274,0.03481611,0.02044104,-0.05304101,0.06879756,0.04214123,-0.0025427477,0.021452144,0.040039435,0.02423851,-0.09250387,0.060048893,-0.042594507,0.04593552,-0.012357168,-0.020152286,-0.050761335,-0.029983805,0.004655999,-0.06785352,0.036573976,0.019525992,-0.015251223,-0.057292994,-0.045851894,-0.009684115,-0.050123468,-0.013097533,-0.06335524,0.04386902,-0.009029113,-0.07397832,-0.008003532,0.014157303,-0.0034376073,0.018110452,-0.046655476,0.021662548,0.05193391,0.055882405,0.035190992,0.058071125,-0.017134948,0.022138052,0.047295816,-0.036678195,0.026963465,-0.083008036,-0.108331874,-0.08665379,-0.029243562,-0.08136723,0.014129535,-0.015545651,0.05668694,0.06406031,0.16891786,0.009297813 +7.1.1.10,"The enzyme, present in plants and cyanobacteria, couples electron transport from ferredoxin to plastoquinone and proton pumping from the cytoplasm to the thylakoid lumen. It participates in cyclic electron flow, retuning electrons generated by photosystem I to the plastoquinone pool, thus bypassing the generation of reducing power. It may also participate in respiration using electrons originating from NADPH via the action of EC 1.18.1.2, ferredoxin---NADP+ reductase (FNR) operating in the direction of ferredoxin reduction. It is a large complex, with some of its subunits resembling those from the bacterial/mitochondrial EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating). However, it lacks the NADH-oxidizing module and instead has a module that interacts with ferredoxin. Several forms of the enzyme exist, differing in their exact combination of subunits used. Some of the forms participate in carbon dioxide hydration rather than electron transfer.",384,0.99999994,-0.08691497,0.03684521,-0.073189124,0.036488783,0.07471424,0.024027241,-0.03420046,0.03631479,0.021934364,-0.027639685,0.0076952684,0.01378256,-0.010744961,0.019870471,-0.05291651,0.019522354,-0.081620485,0.01499315,0.0041380133,0.015618931,0.024548361,-0.0051837335,-0.006329476,-0.034948725,0.056582794,-0.0055287946,-0.007672867,0.014527766,-0.07097736,-0.063441515,-0.04204872,-0.018899791,-0.016341034,-0.03141492,0.020501249,0.17412224,-0.019882565,-0.06966508,-0.017861385,0.0013560993,0.009076708,-0.01880646,-0.016249975,-0.00066756003,-0.03379205,-0.012050999,0.053633958,0.047120884,0.009240017,-0.03329456,-0.032281436,-0.017231079,-0.02460803,0.11633904,0.056957632,0.008935667,-0.0072838496,-0.02290131,-0.031022767,-0.036348723,-0.005248935,-0.044971775,-0.018312056,0.018117763,0.0057778237,-0.016878134,-0.009528043,-0.052357625,0.014204071,-0.08011071,-0.017311336,-0.034198858,-0.026460363,-0.020432033,-0.03686196,0.014628066,0.014187943,-0.0065859845,0.045443095,0.012900735,0.044328462,0.023367025,-0.0039207092,0.045681998,0.038515348,0.006551048,-0.011343191,-0.03815729,-0.08847474,-0.0010699546,0.009050726,0.027516678,-0.04199572,-0.0002836157,-0.09515811,0.017112754,0.05796839,0.03633838,0.026151817,-0.022168618,0.02453915,0.117604196,-0.007924175,-0.14303128,-0.022349628,-0.013748261,-0.009247973,0.13723525,-0.028249785,-0.018244734,-0.019467399,-0.002036551,-0.0046391725,0.0035117173,-0.014845605,0.108711705,-0.0062438664,-0.03947887,-0.09836361,0.03527993,0.0069390708,0.0076352656,0.042387396,0.0052460763,0.0281847,-0.04523213,-0.16377656,2.566914e-33,0.06306742,0.00042178205,-0.029989187,-0.0037936429,0.035985515,-0.0027644164,-0.106979236,0.007191026,0.0005315009,-0.05195055,-0.0830985,-0.03043692,0.06726587,-0.06186281,-0.035456564,-0.09644378,-0.05094361,-0.045454524,0.030366756,0.014386754,0.08145846,0.04333068,-0.0059796,0.019392632,0.025453035,0.05433601,-0.046072893,0.029140348,0.010320088,-0.0057653086,0.058523342,-0.07960436,-0.12484208,-0.004270166,0.07644585,-0.034734506,-0.06828063,-0.035205748,-0.028198453,0.054222256,-0.08689237,0.07072146,-0.057755567,-0.02626269,0.10194193,-0.0773787,-0.0055501754,0.06580912,0.058487874,0.068951376,0.05583233,-0.064274386,0.10002923,-0.042648446,-0.07324491,0.0025890258,0.012132029,0.015599798,-0.02314026,0.049303703,0.06365685,0.058328178,-0.017172402,0.028785333,0.01164838,0.068404905,-0.0632833,-0.0077774557,0.00929063,0.064997114,-0.026327398,0.025639748,0.06112804,-0.032781295,0.11167326,-0.008947624,-0.043896947,-0.01963208,0.033997938,-0.030437326,-0.01650837,-0.05032124,-0.0050440333,-0.05107601,-0.023120925,-0.03170378,-0.018365398,-0.051159598,-0.011380459,0.020319756,0.128737,-0.045458656,-0.04248109,-0.102613226,0.01495934,-3.8668963e-33,0.10033227,-0.054736096,0.031124562,-0.10327095,0.017858142,0.08882502,0.013730567,-0.0085482355,0.0094829565,-0.019152926,0.056716993,0.011033239,-0.0065299273,0.014516966,0.045718316,0.0124019245,-0.02934432,0.024457786,0.019538868,-0.0021985036,-0.030541895,0.0700093,0.044224575,-0.021135584,0.051912427,-0.008589798,-0.059503965,0.03825671,0.14701898,-0.007330106,-0.052329317,-0.016115325,-0.071997,-0.027585156,-0.016700493,0.054304495,-0.08182037,0.03294809,0.07211184,0.056397732,0.07181427,-0.044858247,-0.036771894,0.023478521,0.05484216,0.05413559,-0.15079516,0.029278414,-0.030535392,-0.029041521,0.044590376,0.04218052,-0.08553583,0.030511867,0.04322519,0.060611397,0.054778717,0.037896525,0.02914701,0.018587673,0.0086832,-0.14203162,-0.014244883,0.041599814,0.02065371,0.023936287,0.024313737,0.034959868,0.024978042,0.032123208,0.074199796,-0.019651221,0.04968474,0.022768406,-0.0070599727,-0.02664363,4.474699e-05,-0.010057855,-0.047506817,-0.020433431,0.0025407588,0.022592109,-0.020433655,-0.047056925,0.026532358,-0.070132054,-0.003063874,0.019371947,-0.044016395,-0.011992373,0.01871042,0.023175355,0.0037179268,0.048912026,0.01476886,-4.47974e-08,0.008230699,-0.03751301,0.07728912,-0.033413295,0.10128875,-0.0033775796,0.037684463,0.021120809,0.022615308,-0.018523,0.051770087,0.13816452,0.071936525,-0.09632819,0.06844354,0.028863158,0.0107361935,-0.014654751,-0.016056187,0.00686222,-0.063972645,-0.06643856,-0.2030805,0.08389592,0.0018838623,-0.041760027,0.032359384,-0.005388142,-0.01708796,-0.10728615,0.033650592,0.051422756,0.07181225,-0.04395593,-0.1397665,0.022226492,-0.061076805,-0.022206355,-0.03151529,0.0225759,-0.029524155,-0.04030945,-0.02519087,0.02946682,0.029564539,0.032322086,0.051110025,-0.00040369236,-0.016454559,0.015362425,-0.0034544722,-0.018781448,0.030652573,-0.08192619,-0.08472713,0.09001943,-0.012262171,-0.026306732,0.015736429,-0.031194223,0.011455223,0.0052726315,0.11318795,-0.01007173 +7.2.2.22,"A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, detected in mycobacteria, is a high affinity slow turnover ATPase exporting Mn2+.",384,0.99999994,-0.036640596,-0.047876872,-0.018654408,-0.0071253614,-0.0042900136,-0.020487588,0.063502334,0.053150184,0.03897043,0.031601734,-0.004029384,0.025566088,0.030132972,0.09667477,-0.03797181,-0.015208919,-0.009577164,0.0035538326,0.08752478,-0.011862462,0.09145057,0.06550497,-0.00973993,-0.04819559,-0.00888587,0.056696936,0.04767897,-0.03712752,-0.03984911,-0.021287898,-0.1279452,-0.002999485,0.024731481,-0.045253936,0.0787048,0.14701873,-0.053943917,-0.008558611,0.0772506,-0.038418513,0.14787148,-0.0030730078,0.067553736,0.02354873,-0.0627164,0.013646237,0.02237664,0.0034765974,-0.029284235,-0.024571434,-0.029895468,-0.0333694,-0.0734083,-0.002110792,0.0021823652,0.03194659,-0.04534424,-0.005959244,-0.027816417,-0.013619476,-0.0161262,-0.015002699,0.01653944,0.06678482,0.086926706,-0.05436538,0.051794052,0.03187825,0.0443012,-0.062341344,-0.046323206,0.029027129,-0.07687325,0.02501977,0.0038821774,-0.052268714,0.025712347,0.013936103,-0.0040287715,-0.02116802,-0.027719164,-0.043851793,-0.0032174182,-0.039079085,0.049354408,-0.0027263858,0.06740023,-0.0009997091,0.006455464,0.010304789,-0.002334894,-0.027375028,-0.010780526,0.010801133,-0.10984547,-0.008477664,0.056555368,0.05540004,0.021655234,-0.00571035,0.0683961,0.0861954,-0.0032048302,-0.025036354,0.005120973,-0.009359717,-0.017410351,0.018985098,0.039338224,0.07707563,-0.03096509,0.049613968,0.029004704,-0.024650121,0.039668925,0.09406214,0.018689262,0.016625196,-0.042523578,0.062217254,-0.02871597,-0.09795407,-0.033975307,-0.008935099,-0.07726125,0.073095694,-0.055611692,1.8504762e-34,-0.034534115,-0.057683595,0.051733036,-0.028983416,-0.025634553,-0.019812062,-0.08021306,-0.058109317,-0.037009843,-0.13912655,-0.04385447,-0.06292924,0.020975966,0.07240088,-0.08151821,-0.039135486,-0.040555652,0.044695202,0.1577487,0.014904379,0.02863126,0.018337317,-0.004247066,0.057620827,0.027589425,0.036697276,0.0058411746,0.017921377,0.048023712,0.0078553995,0.02400594,-0.09535887,-0.09155648,-0.06810923,-0.0050325193,-0.073354594,-0.08344826,-0.049000327,0.073562436,-0.048365835,-0.103197575,-0.07154047,-0.035522886,0.012022206,0.029929023,-0.07381194,-0.060076278,0.032171212,-0.07115176,0.051572934,0.039806075,-0.09579478,0.06917469,-0.04246583,-0.07230323,-0.033812005,0.036103185,0.0147875445,-0.011089859,0.038588587,0.10357132,0.11554204,-0.0066621215,0.06936298,-0.02525613,0.01767501,-0.06627888,-0.06447296,0.06524412,0.1146774,-0.053327393,-0.035289884,0.016777843,-0.006960208,0.07936243,-0.016586337,-0.023664426,-0.029821884,-0.01948327,0.027000112,0.0025660677,-0.04255246,0.013454558,0.011655522,-0.055997785,-0.06524499,-0.018188573,-0.091868065,0.011900338,-0.00908261,0.08329902,0.03392102,-0.03550663,0.100964546,-0.0050853537,-1.902876e-33,0.110826515,-0.04414834,0.12859048,-0.085748695,-0.052792028,-0.031015094,0.055914093,-0.0061516166,0.0043683653,0.001764513,0.029819861,-0.027380288,-0.032410894,-0.018158121,-0.01842365,-0.041823097,0.015450724,0.07364396,0.030050248,0.017125355,0.031658664,0.066424884,0.042183023,0.011861744,-0.013961496,0.0024402088,-0.04307678,0.06303142,0.004227964,0.02872189,-0.023870647,0.017066386,-0.016175393,-0.071617715,-0.09604939,0.013053876,-0.011582878,-0.025235603,0.021605682,0.0029811373,0.064628735,0.0709065,0.048456077,0.034830753,-0.02632193,0.0062759826,-0.018690113,0.010095501,0.004070584,-0.01915928,-0.04240286,0.07083448,-0.05714739,-0.0074665365,0.05041876,0.020196047,0.011854424,0.01509858,0.0007335711,-0.051613107,-0.09559648,-0.09990929,0.034003172,0.03893829,0.032623198,0.027228594,0.062606774,-0.001992976,0.001952557,0.05508555,0.03405274,0.10021462,-0.033074457,-0.0045844684,-0.003280581,-0.020723449,-0.010237522,0.014022806,-0.024601731,-0.026607767,-0.056577403,0.016534045,-0.047418404,-0.086382695,-0.0106223235,-0.09711146,0.010183643,0.04998411,-0.004963869,0.027857902,0.022491412,-0.027696693,-0.03505793,-0.012020334,0.001412731,-2.8575176e-08,-0.006719206,-0.06617913,0.08114434,-0.037573595,0.04894263,0.057012267,-0.037316367,-0.018848928,0.10619587,0.01326086,0.039065786,0.030485338,0.03549214,-0.050923932,0.11139099,0.066734165,-0.06572879,0.0024796084,-0.02886715,-0.058983658,-0.0083778165,-0.02912887,-0.08904485,0.1173997,0.067708336,-0.0044362377,0.029773656,0.067304716,-0.031433523,-0.116108656,0.004613053,0.047684032,0.019043962,-0.023763277,-0.07630363,0.051012352,-0.037829712,0.013095838,-0.058083154,0.074962325,-0.046824273,-0.014910018,-0.039972477,0.034634545,0.0067390325,0.07532366,0.0077225184,0.040882308,-0.03912073,-0.016601145,0.022083452,-0.008578343,-0.04816876,-0.077328645,-0.076177284,0.06589415,-0.059283786,-0.04366531,-0.056443047,-0.033802625,0.06046701,-0.01060015,0.104010016,-0.07450032 +7.4.2.14,"An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. This entry describes vertebrate transporters involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with major histocompatibility complex (MHC) class I molecules. The substrates are generated mainly from degradation of cytosolic proteins by the proteasome.",384,1.0,-0.021990001,-0.043059975,-0.014181661,-0.03129712,-0.033212274,0.014950766,0.10302107,0.07918135,0.019536806,-0.019794397,-0.0018262792,-0.01816019,0.028033044,0.11474956,-0.030743284,-0.01415013,-0.0031157928,0.029672619,0.014243915,-0.05133961,0.0011727941,0.063317694,-0.010893059,0.03745089,-0.07992776,-0.02267037,-0.026624419,-0.003064426,-0.00953647,-0.042086344,-0.115641676,-0.033663254,-0.041392546,-0.0010719141,0.022841932,0.0820124,-0.012868394,0.030601494,0.0049347384,-0.03069429,0.13014998,-0.03716296,0.077835366,0.04468937,-0.06762738,-0.014293771,0.014657599,0.029169971,-0.001471196,0.066523805,0.0058791614,-0.027369533,-0.061723046,0.04648724,-0.031655114,0.08744724,-0.047600057,0.022040432,-0.019533277,-0.011638397,-0.08088618,0.0033459538,0.063225165,0.07896419,0.037728835,-0.05908415,-0.037453637,0.0503466,-0.019135598,0.012495606,-0.05477079,-0.079955935,-0.10286557,0.048838682,0.025190808,0.028047904,-0.01960741,0.019201893,-0.015564005,-0.0074360124,0.027064648,-0.023957664,0.01579058,0.0028801349,0.048319682,0.05163003,0.005335711,-0.03664319,-0.032876533,-0.010251037,-0.022448009,-0.11969293,0.026231244,-0.017169593,-0.103782505,0.025401618,-0.018076627,-0.012258394,0.0672663,-0.014485305,0.041237608,0.015120478,0.055565033,-0.039814297,0.00038386096,0.0125376135,-0.027008602,0.05221799,-0.03121063,0.01134287,-0.009596282,-0.04180679,0.033468757,-0.074930936,0.049732383,0.1010962,-0.08083107,0.041067854,0.03768293,-0.018873286,-0.08388528,-0.06244761,0.0124433655,-0.03147562,0.02313624,0.017300257,-0.051342368,2.4312166e-33,-0.08271032,-0.08953375,0.016501106,0.04508899,-0.017584164,-0.06777643,0.017855877,-0.02771405,0.020985933,-0.07774338,-0.031224059,-0.014813646,0.002387193,0.0360989,-0.009474103,-0.015763586,-0.07609902,0.02481829,0.05950509,-0.024400797,0.025635837,0.07607311,0.05371933,-0.07028581,0.07901896,0.048919413,-0.07541956,0.010536625,0.043956947,-0.012492786,0.0043279105,-0.011507738,-0.09398992,0.010890029,0.013060694,-0.026096739,-0.034593053,-0.022152215,0.07293283,-0.022759305,-0.09742384,-0.054964866,-0.09826603,0.043938175,0.06208515,-0.08732463,0.001891,0.03152693,-0.06639748,0.003480765,0.0634721,-0.112881765,0.06114908,-0.09944574,-0.07693328,-0.060124572,0.028594172,0.042562183,-0.059714857,0.0958646,-0.00024934605,0.12895766,-0.040694665,0.043062855,0.07193849,0.0034486323,-0.11985797,-0.07074393,-0.00867194,0.06339803,0.07618518,0.022783553,0.05639723,0.008834571,0.09959295,-0.0089440085,-0.073680125,0.009776118,-0.05307858,0.04078139,-0.014003901,-0.035166502,-0.048604563,0.017328762,-0.056873523,-0.048999917,0.05051784,-0.08947726,0.06529021,-0.020756494,0.09643073,0.04513287,-0.025074901,0.11431973,-0.01889548,-4.3895196e-33,0.061815243,0.02725969,0.122026645,-0.008821872,-0.05306075,0.012006984,0.04625044,0.027938997,0.01614345,0.00797093,-0.026146144,0.02342892,-0.005653177,-0.02574632,0.02752719,-0.10064102,-0.037789356,0.017566174,-0.015852999,-0.038357306,-0.019680312,0.02632961,-0.008107658,0.039521206,-0.041538153,-0.009210753,-0.018333891,0.060977668,0.04999098,0.0023908357,-0.04006236,0.031688847,0.006720186,-0.028676929,-0.057420593,0.048053104,-0.015778692,0.04660204,-0.03398012,-0.016557174,0.046506267,0.03821303,0.003312466,0.04355521,0.02382244,0.078727454,-0.02095365,0.08875623,0.066270754,-0.04587237,-0.008030428,-0.054577418,0.0012521527,-0.035387278,0.044849515,0.11043951,-0.0015289624,-0.03441423,0.06414411,-0.053275116,-0.058460526,-0.055363577,0.035891622,-0.011331711,0.01895947,-0.0075333775,0.046637196,-0.060982183,-0.09689266,0.08009475,0.10817038,0.030906836,-0.016545808,-0.011435894,0.057804443,0.0025611927,0.025825884,0.02719552,-0.014330017,-0.02085903,-0.04312454,0.006757568,-0.016733488,-0.024610596,0.1376374,-0.030359792,-0.04027405,0.0060155806,0.013926095,0.05682513,0.04215415,-0.011206025,-0.0030596044,0.032659885,-0.02186762,-4.2748518e-08,0.07728916,-0.061507136,-0.028495073,-0.106187195,-0.027571881,0.034042023,-0.019624352,0.005797922,0.10131589,0.105066724,0.017548062,0.06969089,0.015573898,0.009704431,0.062041394,0.10962484,-0.029854491,-0.007171617,-0.019261433,-0.09828177,-0.059553124,-0.10515961,-0.013064965,0.068818405,0.02988018,-0.036598135,0.029216027,0.0685649,-0.035423096,-0.082984045,-0.016228952,0.039371796,-0.045103375,0.009234902,0.028734662,0.024915561,-0.022584414,0.0018473438,-0.03584,0.06879106,0.007808985,-0.048612263,-0.05047621,0.00873497,0.05209825,0.014200226,-0.030142507,0.029571136,-0.06112902,0.0076704724,-0.050406434,-0.040635165,-0.035536274,-0.08151235,-0.07737744,-0.035601184,-0.049233735,-0.03598027,-0.01357293,-0.015765501,0.064586975,0.0762063,0.14217442,-0.059658226 +1.1.1.426,"The enzyme participates in the biosynthesis of N-acetyl-alpha-D-quinovosamine, a 6-deoxy sugar that is present in the O antigens of many Gram-negative bacteria, including Pseudomonas aeruginosa serotypes O6 and O10, Rhizobium etli, and Brucella abortus.",384,1.0,-0.08627412,-0.028420383,-0.12764943,-0.018533278,0.02535451,0.011277125,0.005219196,0.070027895,-0.0011749323,0.036553618,0.027527992,-0.019350031,-0.066784255,-0.012003016,-0.10919917,0.09819198,-0.033631098,-0.00054962,-0.0055950247,0.010841305,0.072869025,0.031077009,-0.032601032,-0.0012642052,0.028066274,0.010025418,0.098436914,0.07308047,0.010583654,-0.030196613,-0.041482866,-0.07888624,0.088456884,-0.021991255,0.06391542,0.059895884,0.0573616,0.0101603605,0.0798177,0.036808096,0.014752042,0.0455269,-0.010589534,-0.015609288,0.033992324,-0.050290875,-0.033456355,0.04426398,0.08623467,-0.04311374,-0.036114674,-0.020678109,-0.052535266,0.10070547,0.03144868,0.019439152,-0.037029766,-0.11182352,-0.007982548,0.013171906,-0.0060193487,-0.009928543,0.03878613,0.044311285,-0.0032927722,-0.04954704,0.014759775,-0.0019832428,-0.017033534,-0.027227124,-0.04000169,-0.06469184,0.045819633,-0.0031631878,-0.038585614,-0.019848077,0.018683188,-0.052038755,-0.018210895,-0.0114598395,0.022317646,-0.02248932,0.065888494,0.101986654,-0.025823135,-0.053951435,0.060466763,0.015161818,0.12173836,0.05099955,-0.030272156,-0.053420253,0.04212549,-0.13817239,-0.06877145,-0.0030053593,0.05712235,0.000813342,0.046299502,0.030777486,-0.015390518,-0.0079081515,0.024382308,-0.09160528,-0.013812071,0.018283628,0.037719276,0.11649793,0.03974995,0.018666014,0.0027644257,-0.018934112,0.015030977,0.015256037,-0.078491524,0.037600864,0.002960908,-0.064566284,-0.070318,0.005594031,0.002560605,-0.018680062,0.030882755,0.04841575,0.04510455,0.064994544,-0.057390183,2.4637757e-33,0.030561103,0.011503289,-0.024105988,-0.05293953,0.025966765,0.020054625,-0.07043935,-0.040359773,-0.02197263,-0.020140897,-0.09438505,-0.07661614,0.03127419,0.010945512,-0.0088677835,0.07683358,-0.068715006,-0.05209601,0.01719532,0.047267094,-0.0030473687,0.014354671,-0.08890788,-0.027384853,0.02626933,0.05870616,-0.00057811564,0.050114367,-0.018510764,-0.003418304,0.04790085,-0.0042073624,-0.06339057,0.0022530544,0.110850714,-0.010854702,-0.014782856,0.0076854588,0.039101284,-0.015601508,0.042054154,0.067394495,-0.05451681,-0.018416215,0.045072682,-0.058537744,0.008133733,0.11933983,0.058020316,0.083512485,0.04278491,-0.060703654,0.05921,0.031946436,-0.08092037,-0.040482033,-0.06974519,-0.024357961,0.08143216,0.044125337,0.010543165,-0.0047620805,-0.019386247,-0.037392925,-0.037090346,-0.03247892,-0.014940002,-0.042504743,0.044816397,0.012789586,-0.069510914,-0.07007914,0.011834679,0.02491189,-0.032803755,-0.05012623,-0.0061188554,-0.003648128,0.028824229,0.014066329,0.0395959,-0.039527208,-0.031894226,-0.057493787,-0.051463403,0.025272153,-0.07787712,-0.06621136,-0.0072147613,-0.008491593,0.11199242,-0.10232147,-0.11272077,0.06285576,-0.012725462,-3.8295865e-33,0.04022708,-0.12961808,0.03687605,-0.066773646,-0.069161646,0.08949796,0.048615105,0.034655046,0.004763161,-0.029026486,0.043990258,0.030110298,0.014012619,0.023881545,0.03670342,0.017150179,-0.006371979,0.102900654,0.017553119,-0.061194133,0.007786812,0.060531836,-0.020711666,-0.04859016,0.06697995,0.08053925,-0.022986237,0.09475689,0.019316742,0.06444329,0.015976114,0.008664145,-0.03355289,-0.0051208413,-0.0256534,0.02729597,0.0050428202,0.004845268,-0.007651165,-0.0027640748,-0.011552728,0.015610632,0.00974128,0.09825787,-0.015665423,0.08262702,-0.032927502,0.039704643,-0.0045396434,-0.05139123,0.044116475,-0.020892985,0.028029295,0.058884226,-0.025479006,0.01129998,-0.03603303,0.010593149,-0.04255908,-0.019222137,-0.014914546,-0.10758587,0.04728687,-0.0023158954,0.013568084,0.058713973,0.015685206,0.07803014,0.022571001,-0.036390644,0.0109957345,0.014713428,-0.017787395,-0.031970173,-0.049353722,0.0038140141,-0.051771764,-0.0493756,0.011731804,0.015247994,-0.03173858,0.015748547,-0.024822537,0.04285191,-0.13315366,-0.05340138,0.091131955,0.09754081,-0.042434666,0.05084081,0.0030348357,0.01022386,-0.024428813,0.027256694,0.054577615,-4.3933607e-08,0.05156287,-0.12159078,0.057587147,-0.04746703,0.0032480322,0.054576866,-0.059622705,0.046453547,0.039849445,0.017872317,0.046220545,0.14025423,-0.03786258,-0.00014057275,0.028233398,0.020846961,-0.060752477,0.029303249,-0.04066668,0.006043337,-0.054972906,-0.048169576,-0.1101039,0.059876967,-0.005085504,-0.06321486,0.026170624,0.00800349,-0.05915334,-0.041365247,-0.053787645,0.043413438,-0.065166384,-0.05774848,-0.10767891,0.013923188,-0.02888172,-0.06396341,0.0013656296,-0.087935574,0.051990293,-0.017574225,-0.1055554,-0.0075649284,-0.0038296883,0.041615356,-0.022052808,0.0013068395,-0.041781165,-0.03189565,0.038705263,-0.046029586,-0.0006385049,-0.05515355,-0.1324977,-0.034823276,-0.03479204,-0.07431091,0.0029573978,0.04688746,0.012246429,0.030923631,0.1855834,-0.037605494 +1.1.5.14,"The enzyme, characterized from the bacterium Gluconobacter japonicus, is a heterotrimer composed of an FAD-containing large subunit, a small subunit, and a heme c-containing subunit, which is responsible for anchoring the complex to the cytoplasmic membrane and for transferring the electrons to ubiquinone.",384,1.0,-0.09403696,-0.024791818,-0.11415505,-0.0076079564,-0.001176138,-0.00038316086,0.00024695,0.07521617,0.038503204,-0.038750157,0.04179239,-0.061006628,-0.07032998,0.059186626,-0.030780539,-0.050701704,-0.07031257,-0.00040037505,-0.07385783,-0.08591179,-0.005138338,0.050011575,-0.0167067,-0.058952328,0.0319635,-0.014649041,0.029848946,-0.048540078,-0.019460216,-0.03501824,0.0031022606,-0.062027235,0.07009333,-0.012754254,0.04292213,0.06403031,-0.016310968,-0.11436666,0.08331541,-0.014909157,0.056365587,0.03158958,-0.0163142,0.026970867,-0.008672143,0.07533343,0.024742156,-0.0036437844,0.021988038,-0.00943313,0.0016400322,-0.09771364,-0.057112396,0.05362752,-0.015457937,0.040183786,-0.0107516125,-0.04381818,0.0030021146,-0.0060661533,-0.0054816077,0.047018763,0.051974505,0.008825572,0.017173098,-0.076542206,0.00613981,-0.05835629,0.013313165,-0.030138712,-0.006900891,-0.07093111,-0.07037609,-0.010233127,-0.034024086,-0.0057139182,-0.036544673,0.032706242,0.09040572,0.0032976777,0.06980093,0.02124776,0.07727661,0.09991004,0.0061058225,-0.010025048,0.060381502,-0.0209618,0.006398916,0.023287717,0.0040683495,-0.0149836335,-0.022270503,-0.08330811,-0.10067904,-0.01610576,0.03906989,0.05802187,-0.012631143,0.00032345534,0.06011261,0.046642393,0.09638232,-0.04968672,-0.09277232,-0.042296845,0.0036267806,0.15512812,0.026524233,-0.028548947,-0.054926753,0.047862526,-0.0066806534,-0.04011332,-0.04138686,-0.011418188,0.07008439,0.00014667521,-0.006538513,0.043106597,0.015302696,-0.006312013,0.051871233,0.05310819,0.0072996086,0.024245149,-0.1608482,-1.3869929e-34,0.062918656,0.0063236947,-0.015018282,-0.05267169,-0.06555703,-0.002020314,-0.102383204,0.0046799295,-0.06258905,-0.0022327572,-0.06857218,-0.068743214,0.02140667,0.047865234,0.03293982,0.019633807,-0.09226947,0.0038871274,0.06187808,-0.0100562535,0.057145465,0.027505664,0.0026695372,-0.021706214,0.046502497,0.000569398,-0.045059897,0.02790494,-0.021300772,0.004834995,0.019542843,-0.08888232,-0.07538277,0.022577984,0.064421065,0.012513303,-0.037450504,-0.050784353,-0.005013326,-0.035484273,-0.011386579,0.007315477,0.02059289,-0.0036405686,0.12765558,-0.021051135,-0.023449976,0.09762634,0.007411359,0.079773754,-0.01383665,-0.045265216,0.13057788,-0.017622072,-0.013751943,0.10016781,0.029969674,0.026018826,0.014497005,0.04524775,0.047828466,0.11642725,-0.085708946,0.09723957,0.02824144,0.054981384,-0.058165055,-0.05135046,0.021956228,0.1324747,-0.043371104,-0.09621759,0.0427794,0.025955262,-0.01808033,-0.066702195,-0.07182085,-0.042153563,0.0017684118,-0.031669095,0.012614868,-0.052575406,0.025175996,-0.06835366,-0.06021077,-0.0036279764,-0.009285789,-0.038243998,-0.069243066,0.010143111,0.12325027,-0.03933066,-0.050911777,0.0036391555,0.03419936,-1.482646e-33,0.093835935,-0.06673611,0.029530955,-0.05580485,-0.019961081,0.016085511,0.0072113136,-0.061550148,-0.015599917,0.026668733,0.057508852,0.043532953,-0.019065777,-0.01943536,0.008133754,-0.007954243,-0.028652744,0.012625552,0.04668044,0.0025583631,-0.028911144,-0.024501793,0.069374196,-0.054112654,0.03710924,-0.028932624,0.0150207,0.065674424,0.04347052,0.013884307,-0.061355926,0.0070323143,-0.039472234,-0.09030467,-0.039045233,-0.013876149,-0.013400748,0.0154481735,0.07539154,-0.06922748,0.0101181585,0.0057367645,0.021389574,0.07087968,0.033772886,0.08254231,-0.10300984,0.066622935,-0.032850914,-0.043831706,-0.062179614,-0.00856992,-0.008359009,0.0005008747,0.0040159095,0.063567445,0.041631475,0.0049312455,-0.065163575,-0.012697883,-0.0033015753,-0.07255326,0.051882003,0.032596912,0.05050523,0.01086967,0.031153696,0.05619652,0.022115154,0.024565037,0.08571365,0.0065464512,-0.003037938,0.002895646,-0.029695332,-0.055044744,-0.054921366,0.01897485,0.05695093,0.015069001,0.06806524,0.015138508,-0.039423842,-0.041237663,0.0134974765,-0.12704659,0.0024640022,0.14247312,0.0038862217,0.04632657,0.0035999806,0.039673824,-0.011118448,0.026821215,0.017112335,-4.0811788e-08,0.005381521,-0.044697873,8.857011e-05,-0.08837259,0.06273111,0.03848945,-0.050320305,-0.07411731,0.03338846,0.0666206,0.010584094,0.08731323,-0.06793975,0.0022211897,0.043739058,0.033322114,-0.061984457,0.023642499,-0.0035104766,0.06098804,-0.0063558733,0.018937169,-0.12265495,0.03743776,0.026440607,-0.07473129,0.01681049,0.06831482,-0.031085825,0.041877754,-0.020832088,0.048234563,0.00680015,-0.060925942,-0.11827431,0.020122012,-0.038382933,-0.04689722,-0.054318566,-0.035657916,0.034985166,0.03307537,-0.060364027,-0.005629142,0.016705299,0.066030815,0.03267078,0.026053825,-0.06856268,0.02816656,0.036948744,-0.06191284,-0.0009533773,-0.011518307,-0.110987425,0.013434659,0.01318127,-0.100403346,-0.001129654,0.0071776304,0.010554297,0.036068115,0.14370492,-0.0094494475 +1.2.1.107,"The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arsono-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system.",384,1.0,-0.049080312,0.014718258,-0.09440437,0.0031532878,0.08372112,-0.057265412,0.03292191,-0.008090872,0.020367425,-0.03959725,0.05684874,-0.021984475,-0.02808378,-0.03709636,-0.07523393,-0.05445004,-0.098627456,-0.007199099,-0.00031909085,-0.085436344,0.073961794,0.06838552,-0.012796588,-0.0016351492,-0.018796217,0.025469007,0.1155369,0.030206947,-0.046401758,-0.09242233,0.029467588,-0.082554206,0.065751955,-0.02875148,0.028139403,0.09015275,-0.06737562,-0.066479005,0.038338806,-0.02118571,0.054311164,0.03180976,0.013669775,-0.006051185,-0.081408486,-0.00047167574,-0.030100077,0.008469599,0.015806306,-0.01706696,-0.035379194,-0.025456375,-0.05002023,0.034712736,0.043508045,-0.0041965456,-0.05803902,0.00546035,-0.07067649,0.022479812,0.054315954,0.05291408,0.06792195,0.0467303,0.04400707,-0.049571183,0.13489094,-0.08659609,-0.013039644,-0.08776472,-0.031149102,-0.059475455,-0.028925087,0.02199078,-0.010471419,0.08657883,0.029249456,-0.013133361,0.019276215,-0.019468302,-0.0037400597,-0.053244688,0.08492502,0.06643793,-0.044424042,-0.027473487,-0.0032747707,-0.034782358,-0.010343993,0.01863028,0.047994055,-0.040458456,0.040907435,-0.047290258,0.012663544,0.062830895,0.037971154,0.0968259,0.023873957,-0.057895772,-0.064387165,0.13821603,-0.056578826,-0.007054966,-0.034174036,0.0023813164,-0.015904577,0.05679122,0.019194333,-0.021516774,0.017589591,-0.0025186755,0.07097538,-0.003601537,0.0018016321,0.064470746,0.050670445,-0.032372914,-0.010088897,0.054116543,-0.008505666,-0.029110527,0.053249944,0.07180658,-0.032900333,0.056079265,-0.16098088,-1.2225429e-33,-0.0023325628,0.06853385,-0.002885456,-0.04694767,-0.0061500273,-0.035862993,-0.04930395,0.03393845,-0.057216123,-0.028105607,-0.09332024,-0.06400714,0.06969554,0.010041639,-0.01382633,-0.031551015,-0.080062345,0.0032127793,0.020958424,-0.00953458,0.020460809,-0.0050344365,-0.023617726,-0.05442708,0.025500031,0.08748448,-0.01342589,-0.01558627,0.03428021,0.008600521,0.009930007,-0.09461539,-0.080461435,-0.01715696,0.021349741,-0.01782392,-0.03236336,-0.018206641,0.0031911496,0.045958526,0.023488274,0.0041538165,0.04003334,-0.0026760646,0.063777305,-0.036145624,-0.06972761,0.035477236,0.09592009,0.03089593,-0.015587186,-0.03270554,0.12380122,-0.10255786,-0.03547425,0.024790037,-0.0226243,0.001103745,0.053098995,0.10969186,0.0153733,0.0719318,-0.059310053,0.046900854,0.03582501,0.017765542,-0.052833732,-0.07199902,0.04371045,0.0985483,-0.047244065,-0.03312533,0.07359559,-0.0027832263,-0.052471336,0.00096144713,-0.094076164,-0.018064404,-0.04155402,0.03660802,-0.09500738,-0.034498636,-0.011684783,-0.016195843,-0.027980063,-0.03394074,-0.06532757,-0.014244218,-0.0032744585,0.046848975,0.09691479,-0.059330344,-0.109094016,-0.011430954,-0.03488739,-1.1974164e-33,0.07279118,-0.051830087,0.041252214,-0.051977113,-0.03800314,0.048909858,0.043435805,0.07629305,0.010660238,0.06852009,0.057353288,0.05839243,0.04366986,-0.11706679,0.0440229,0.018397884,-5.8970872e-05,0.03436269,-0.027680403,0.027869137,0.06275834,0.082537495,-0.02649142,0.022450315,-0.00040080596,-0.0017296511,0.0053057405,0.059548188,-0.0030358012,-0.021207973,-0.06973535,0.05061111,-0.03651455,-0.05717447,-0.09695343,0.026032891,-0.068631425,-0.013415106,-0.0022229156,0.0005244578,0.023868393,0.079252146,-0.038499,0.09027156,0.06278231,0.09407874,-0.036488567,0.056844924,0.07238947,-0.0026904289,-0.0012749425,0.031703714,0.0011194488,0.05829414,0.07033902,-0.006084233,-0.0104645025,0.051402446,-0.07255522,0.05892204,-0.032414623,-0.07320677,0.079614185,0.027884068,0.028462183,0.034516722,-0.056403056,0.03287698,-0.009328683,-0.014043604,0.025736397,-0.03655031,8.256207e-05,-0.027506739,-0.0596314,-0.0073293294,-0.11425186,0.015770897,-0.008513991,-0.036831044,0.051708017,0.011470828,-0.0031556298,-0.0064236415,0.06553028,-0.060236875,0.0076500755,0.10114469,-0.03230808,0.013883081,-0.08104396,-0.06615315,-0.084110685,-0.043014687,0.0041724406,-3.937389e-08,0.00042137768,-0.05074797,0.09926167,-0.04486869,0.028714828,0.038929727,-0.034272153,0.045292515,0.027563665,-0.0512598,0.013022531,0.06930912,0.018434213,0.024345139,0.05353597,0.019427368,-0.0063352296,0.053633288,-0.0026560707,0.009352629,-0.044273283,-0.02917822,-0.07696094,0.03304505,0.042340484,-0.022519723,0.0211959,0.011258844,0.0057401583,-0.075115286,-0.08261235,-0.0068348083,0.06447949,0.035632964,-0.06095345,-0.0455128,-0.028949214,-0.021761777,-0.08531172,0.016094059,0.01956458,-0.013424241,-0.059210375,-0.006121052,0.007951573,0.062161423,0.010564275,0.036665183,-0.030793348,-0.0217865,0.031334795,-0.071954705,-0.0065354505,-0.037713222,-0.062475912,-0.04710304,-0.05130727,-0.067681685,0.04389091,0.040578827,0.069294155,0.053137682,0.1841259,-0.039722163 +1.13.11.92,"Contains heme. This plant enzyme catalyses the (2R)-hydroperoxidation of fatty acids. It differs from lipoxygenases and cyclooxygenases in that the oxygen addition does not target an unsaturated region in the fatty acid. In vitro the product undergoes spontaneous decarboxylation, resulting in formation of a chain-shortened aldehyde. In vivo the product may be reduced to a (2R)-2-hydroxyfatty acid. The enzyme, which is involved in responses to different abiotic and biotic stresses, has a wide substrate range that includes both saturated and unsaturated fatty acids.",384,1.0,-0.027485767,-0.03493004,-0.0015793302,0.052124515,0.06468321,0.026928991,-0.13450028,0.024301585,-0.002374548,-0.04321165,0.025576314,-0.07947595,-0.063403584,-0.09215331,-0.0270946,0.040402833,-0.031103795,-0.004504354,-0.0556496,-0.07842762,0.089784026,0.048843488,-0.073492095,0.010977228,0.024952,-0.07595507,-0.0037360752,0.0094347885,-0.003242865,-0.088365175,0.052885797,0.0026799804,0.05579843,-0.033130072,-0.026934281,0.05357691,0.005221689,-0.10285871,0.013584071,-0.002741114,0.028986445,-0.06622582,-0.071388744,-0.020443581,-0.022149498,-0.02927009,0.034311015,0.012923822,-0.0057178834,-0.037477758,-0.04063694,-0.013191741,-0.045267865,-0.008901194,0.004685604,-0.018125745,0.010707783,0.08091197,-0.05277108,0.034277096,0.068083,-5.7562822e-05,-0.032451734,0.0338573,0.01560856,-0.09455004,-0.048218433,-0.055314213,0.0015877088,-0.064217284,-0.036732625,-0.09582113,0.00093817967,-0.003898764,-0.058901962,0.03818915,-0.107976034,-0.023337323,0.051567946,0.013822193,0.053609367,-0.009877781,0.008659479,0.09503083,0.0051561473,-0.012159325,-0.02193588,0.024947315,-0.014379203,0.059763942,0.09564524,0.008055283,-0.033878695,0.0697983,-0.08155746,0.072950885,0.10472363,0.0031902555,-0.0026990366,-0.06964074,-0.030293643,-0.00091442233,-0.01618502,-0.13609715,-0.043086004,-0.001989699,-0.060512375,-0.0003833769,0.07428058,0.044063937,0.032583598,0.006898061,0.026981821,0.020895464,-0.018688895,0.101873115,0.048365675,-0.0874222,-0.041066542,-0.03477132,-0.009139234,-0.06610736,0.04512295,0.0027623044,-0.012178214,-0.018239655,-0.106251046,1.6261515e-33,0.03745773,-0.053816758,-0.06290086,0.010246103,0.007424968,-0.047729015,-0.097006425,0.045663275,-0.029692246,-0.0099965315,-0.065707445,-0.06823011,0.034066457,0.04648271,-0.014364554,-0.031051354,-0.07046675,0.010335206,0.101320066,0.037575964,-0.028608589,0.0073883515,-0.09450211,0.004139968,-0.017279904,-0.0007358363,0.033956733,-0.072942436,0.032352395,-0.0088085905,0.0054002497,-0.12578183,-0.045321893,0.005797527,0.058343034,-0.0037359947,-0.0066879964,0.00923148,-0.064706616,0.05125898,0.025435757,0.029429654,0.08925562,-0.05302202,0.114800066,-0.048320636,-0.053491674,0.053843115,0.010365332,0.06382482,0.085322045,0.031278487,0.09753538,0.040315017,0.01466205,0.0492858,-0.027495194,0.027367767,0.034560632,0.057077017,-0.0016865763,0.04356455,-0.058685523,0.0076933596,0.0013739624,0.019471832,-0.106162705,-0.0145399645,-0.044552714,0.1336258,0.00894,-0.045609035,0.07784878,0.011701371,0.025018305,-0.024588082,-0.047159627,0.093316175,0.04900855,-0.0040850276,0.025078561,0.050544277,-0.0016816908,0.00047007846,-0.10548149,0.009195731,-0.04450991,-0.007430088,0.0028678458,0.039039347,0.07014097,-0.057822213,-0.062662154,0.0070443274,0.06703732,-3.6058216e-33,0.11444798,-0.08493027,0.016484564,-0.052696936,0.071267754,0.04763115,0.0037236577,0.014394571,0.07894866,-0.041226566,0.084287554,0.037253,-0.006472821,0.037295956,0.02666313,0.02271571,-0.008892731,0.106567666,-0.06275407,-0.022231128,0.03499251,0.06673869,0.014618521,0.06061205,0.018927863,-0.044134296,-0.025322502,0.018283082,0.06141774,0.088259354,0.045378126,-0.019889265,-0.082932934,-0.005335867,0.0006879963,0.051039822,-0.094291024,0.02009775,-0.015211463,0.060769755,-0.0035211577,-0.016578825,0.040062863,0.03683142,0.087010406,-0.021516485,-0.06304313,-0.043829054,0.0064573116,-0.039589502,0.03130431,-0.005347513,-0.046775784,0.0878966,0.079871394,0.033517946,-0.019318363,0.01326082,-0.013568392,-0.024826577,-0.057015665,-0.046744857,0.014408372,-0.038402207,-0.031901956,0.04085626,-0.039971188,-0.011560508,-0.038176756,0.058612633,0.08906227,0.032562867,-0.030226361,0.054782398,-0.026538596,-0.042125158,-0.0324988,-0.05039152,-0.0638369,-0.010529328,-0.040740725,0.036596406,0.012336985,-0.107135974,-0.0068509607,-0.073972024,-0.06722957,0.06576694,0.012594716,0.023991428,0.0057492373,-0.03428543,-0.05957596,0.0029287888,0.044038173,-4.6777522e-08,-0.08239912,-0.11014364,0.017999148,-0.032587506,-0.0653647,0.019987576,0.05926262,0.029431734,0.05836799,-0.0347261,-0.006527334,0.09607434,-0.032679264,0.062767066,0.056886017,0.0123387985,0.04462545,0.046685524,-0.0065225256,-0.020259166,-0.04212549,-0.04248638,-0.06614827,0.030569755,0.005873618,-0.05312357,-0.016126163,0.018423785,0.0817267,-0.0049723587,0.0777187,0.08710285,0.05157605,-0.02084793,-0.046213713,-0.013456809,0.0114027485,0.010212704,-0.030082218,0.0615782,0.0062738326,-0.05866913,-0.061705615,-0.010277145,0.05916762,-0.0036088754,0.001248406,0.033577863,-0.007646431,0.0037703395,0.07459109,0.00040373422,0.0035562387,-0.027025903,-0.053667594,-0.034472648,-0.0137169575,-0.005525964,0.030579055,-0.05934094,0.01851603,0.063817725,0.2058311,0.004433051 +1.14.11.77,"Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. The type II sulfatases oxidize the C-H bond of the carbon next to the sulfate ester, using 2-oxoglutarate and oxygen as substrates. The resulting hemiacetal sulfate ester collapses, liberating inorganic sulfate and an alkyl aldehyde along with carbon dioxide and succinate. The enzymes often desulfate a broad spectrum of linear and branched-chain sulfate esters. The enzyme from Pseudomonas putida acts on a range of medium-chain alkyl sulfate esters, with chain lengths ranging from C(4) to C(12). cf. sulfatase EC 3.1.6.1, arylsulfatase (type I), EC 3.1.6.21, linear primary-alkylsulfatase, and EC 3.1.6.22, branched primary-alkylsulfatase.",384,1.0,-0.06194923,-0.10354814,-0.05201775,-0.036171447,0.02887665,0.0077789356,-0.09582826,0.024918687,0.038635444,-0.06595105,-0.014205564,0.030068388,-0.06040315,0.07119407,-0.028822877,0.04315569,-0.06872424,0.0005748575,-0.013855625,-0.019916447,0.14112395,0.052829184,-0.11054336,0.010277337,0.018240584,0.04126748,0.01614076,-0.0014361837,-0.056763183,0.00077243475,-0.044314224,-0.1307249,0.02761845,-0.07005584,0.05026227,-0.0018361233,-0.056497082,-0.023945348,0.030222384,-0.028085828,0.08745596,0.043087814,-0.008533352,-0.077869825,0.0013228919,-0.0953233,0.008803135,0.0062975823,-0.011818426,-0.059889656,-0.03204152,-0.06289258,-0.02518998,0.06942808,0.0019942576,-0.050136693,-0.068557665,0.03159342,0.014664802,-0.020665709,-0.024590809,0.010032718,0.01930636,-0.06360477,0.006386486,0.009889207,0.027724955,-0.07048557,0.0017842159,-0.029726647,-0.13661604,-0.056547184,-0.049916595,0.07364309,-0.0036153845,0.032687105,0.035745952,-0.04910821,0.0140730245,-0.049030203,0.022637289,-0.003616773,0.00847872,0.12440379,0.015453864,-0.013417398,0.01810058,0.019404331,0.032821745,0.06520088,0.002764182,-0.011143451,-0.014504599,-0.03337851,-0.014003208,0.03271065,-0.0064898515,0.18396287,0.03946337,0.0099055,0.049564943,0.01595958,-0.00677847,-0.149035,-0.028505074,0.024849167,0.034027208,0.09109218,0.024288137,0.030921873,0.0114595145,0.0068819732,0.045197938,-0.011316398,-0.04140347,0.13255481,0.056648534,-0.04906279,-0.11058296,-0.0037485159,0.031049486,-0.022021364,0.09366602,0.0044807703,0.042768557,0.041118316,-0.15789954,1.8471985e-33,0.0068169544,0.0600477,0.06477795,-0.008104139,-0.039850198,-0.059951056,-0.08485661,0.065544635,-0.0063132094,0.07414419,-0.027870705,-0.010519536,-0.0037741438,-0.015740044,-0.007094513,-0.012545574,0.045601964,0.036674365,0.004530907,-0.0058549563,0.042771373,0.043048743,-0.028436597,-0.04367498,0.061915305,0.025040088,0.04187331,-0.024125723,0.018624835,0.009110135,0.08258659,-0.103638366,-0.10952208,-0.047503628,0.090132006,-0.041458294,-0.044646952,0.020336758,0.029457396,-0.014156304,0.03985905,0.0404235,-0.0220053,-0.018707603,0.058438573,-0.060378145,-0.029875768,0.12131251,0.0021408836,0.0643589,0.00034894937,-0.06389464,0.071903214,0.021354554,-0.024047438,0.016053893,0.0018298366,0.0057570776,0.08357315,0.043003686,0.038628142,0.043235473,-0.06420218,-0.020382138,-0.029412868,0.0074971006,-0.0704453,0.017726101,0.029149055,0.06480659,-0.032552265,0.0031288797,0.0020778724,0.060121473,-0.00061444356,-0.04281208,-0.030642709,0.025754327,0.07427019,0.0034579143,-0.08390212,-0.06897791,0.0015486407,0.0007576405,-0.15557456,-0.020752724,-0.035285104,0.025191637,-0.027049124,0.0002690148,0.004947813,-0.031662945,-0.051685873,0.014582901,0.00053271104,-3.082416e-33,0.09533699,-0.056227814,0.019642428,-0.16164115,-0.033060692,-0.007006836,0.019894483,0.027060919,0.019282186,-0.0586416,0.050767723,0.043502305,0.0599218,-0.016859964,0.048388727,0.061168943,-0.042271152,0.0149073,0.008776987,-0.053650346,0.044465005,0.06888835,0.01920857,0.091630146,0.014368074,0.04028523,0.009342175,0.067291215,0.07139641,0.106185526,-0.0038647573,0.0053012096,0.01698636,-0.075861916,-0.054959096,0.0059388,-0.007759771,-0.028767604,0.035768945,0.038268708,-0.00058061996,-0.008002782,0.024044182,0.075028636,0.0036089132,0.054315753,-0.063060775,0.0130597055,0.03589667,-0.063350916,0.023040522,-0.024275698,-0.017515656,0.015250011,0.020755231,0.028773822,-0.0035028025,-0.008160192,-0.10197612,-0.027972888,-0.065457605,-0.054409787,-0.00053421117,-0.047107726,-0.028204106,-0.02645481,-0.01512495,-0.09929887,-0.035593655,-0.023252085,0.005169675,-0.014451358,-0.06985678,-0.05798176,-0.052322075,-0.07186343,-0.0093522165,0.030624568,0.011460755,-0.024614448,0.004171756,0.038328245,0.024716055,-0.039234497,0.034160554,-0.036108848,-0.012426276,0.12185828,-0.03666277,0.016381184,-0.046992674,0.017956877,-0.016483681,0.08712449,-0.05000938,-4.6299995e-08,-0.032098826,-0.029860143,0.07491993,0.04241367,-0.06624358,0.0549106,-0.010170308,0.0068343095,0.04317721,0.0388413,-0.00014462367,0.06882753,-0.013567697,-0.0006013985,0.08199294,-0.011708792,-0.059923224,0.0025673588,-0.026481027,-0.028457925,0.0014809369,-0.039708145,-0.08118254,0.03588613,0.067083515,-0.09300062,-0.0055710054,-0.026627371,-0.055462193,0.07990409,0.0075064916,0.085983604,0.022298068,-0.02827721,-0.008061152,0.018319441,0.00032120664,-0.041390497,-0.037694775,0.011978317,0.036081355,-0.024214135,-0.09944738,0.003151919,0.07055671,-0.008476665,0.02694466,0.051800378,0.0065598493,0.007846614,0.06336345,-0.00334621,-0.0008036923,-0.009684319,-0.035047777,0.057894334,0.022435524,-0.061403215,0.035210278,0.032300062,0.12722287,-0.037467487,0.1409623,-0.02212061 +1.16.99.1,"Methyltrophic corrinoid proteins must have the cobalt atom in the active cobalt(I) state to become methylated. Because the cobalt(I)/cobalt(II) transformation has a very low redox potential the corrinoid cofactor is subject to adventitious oxidation to the cobalt(II) state, which renders the proteins inactive. This enzyme, characterized from the methanogenic archaeon Methanosarcina barkeri, reduces cobalt(II) back to cobalt(I), restoring activity. The enzyme acts on the corrinoid proteins involved in methanogenesis from methylamine, dimethylamine, and trimethylamine, namely MtmC, MtbC, and MttC, respectively. While in vitro the enzyme can use Ti(III)-citrate as the electron donor, the in vivo donor is not known. The enzyme from Methanosarcina barkeri contains a C-terminal [4Fe-4S] ferredoxin-like domain.",384,1.0,-0.010447957,-0.022260271,-0.15591438,0.023944298,0.10125283,-0.014566324,-0.060389474,0.00032188115,-0.043506533,-0.06279421,-0.07566638,-0.07630341,-0.032654583,-0.012154769,-0.0125223035,0.086415276,-0.032071065,-0.036064647,0.010969324,0.031641237,0.033864398,-0.034124862,-0.07502292,-0.040107597,-0.06435625,0.0039948514,0.017433327,-0.014604063,-0.025111774,-0.014743105,-0.025851667,0.021805137,0.03928957,-0.018169502,-0.006081878,0.10016759,-0.0015075593,-0.0693749,0.048670124,0.011147995,0.016713928,0.056871872,0.073914975,-0.05426833,-0.00730626,-0.07854059,0.040016137,-0.026613045,0.016318554,-0.010494,-0.059371065,-0.039238073,-0.027420178,0.07819326,0.0060138404,0.0506502,-0.08263594,-0.02128691,0.050616205,-0.013150694,0.0428324,-0.06783899,0.05416081,-0.016751776,0.09744281,-0.020130824,0.011630498,-0.11460159,0.05899019,-0.087994546,0.00095692143,0.0048244004,-0.051165696,-0.047185548,-0.02022028,0.046423644,0.06928311,-0.053933743,0.08216569,0.001702372,-0.054533925,0.10406397,0.09971649,-0.011038478,0.01768706,0.071604475,-0.026535453,0.02724681,-0.032566357,0.0536751,0.03424506,-0.010062804,-0.009866041,0.031936534,-0.086335905,-0.039643582,0.14137992,0.07897229,0.0027317137,0.018850902,-0.0019683917,0.048343338,-0.074659795,-0.06322146,-0.07862287,-0.019266987,0.085429035,0.113283284,-0.013096396,0.1162991,0.0122152055,0.047609273,0.025184602,0.024378967,-0.006647921,0.11505436,0.022376738,-0.030426258,-0.029840142,0.015216842,0.071330674,-0.014773324,0.012038992,-0.054925304,0.0027068378,-0.004691324,-0.023694217,2.0236275e-33,0.049767975,0.044528093,-0.0037631614,0.014561699,0.039780352,-0.010333733,-0.08823615,0.015824536,0.031457335,-0.028483212,-0.07101812,0.023490386,0.04986165,-0.018650647,-0.10332522,-0.061725847,-0.019900251,-0.086848825,0.0283458,0.018596085,0.037938774,0.1115541,-0.03389854,0.021797245,0.008650787,0.014321788,-0.046095733,0.0054165693,0.037390534,0.029706292,-0.01578734,-0.07482249,-0.1042724,-0.022993831,0.0794792,-0.009465828,-0.03436334,-0.019470006,-0.022869397,0.013964745,0.06025868,-0.0013164884,-0.07601264,0.008383633,0.034947295,-0.10381791,-0.031835545,0.06723552,0.004402106,-0.0136490455,-0.018891133,0.023823826,0.05537341,-0.060235612,-0.112334006,-0.0328927,-0.0063656666,-0.0640538,0.05110511,0.07108543,-0.009774828,-0.00386126,0.047495436,0.09657672,-0.0045016916,-0.0026897846,-0.049445473,-0.04159621,0.08100201,0.020311251,-0.02270821,-0.054145016,0.053795826,0.060816772,0.01594545,-0.041369855,0.023035025,-0.008388161,0.07685145,-0.013645341,0.07433373,0.028716125,0.04261881,-0.06305033,0.019765597,-0.011172393,-0.047584485,-0.08278354,-0.045016386,-0.022400271,0.005273535,-0.021959497,-0.024316978,-0.047222864,-0.0023328243,-3.5684173e-33,0.081264965,-0.10895936,0.06302736,-0.12189112,-0.10274476,0.08554227,0.0040164255,-0.087238416,0.019246878,-0.07784396,0.15403032,-0.012552754,-0.007741729,0.014214301,0.048817538,0.02801243,-0.06358038,0.09982217,-0.0065215006,-0.0457309,0.002734595,0.047076385,-0.060963064,-0.03951482,0.009520538,0.021419948,-0.05742399,-0.014985493,0.09939009,0.081528366,-0.017388681,-0.030221941,-0.044241246,-0.028097885,-0.020376338,0.0026134073,-0.054467842,-0.037259113,0.033085745,0.027494088,0.0053614327,-0.027725646,-0.02136351,0.050465636,0.044246506,0.03364548,-0.14738148,0.017489346,0.014249818,0.04566961,0.027081806,-0.04829488,-0.087195635,-0.026105998,0.059520695,0.046385404,0.0563387,0.014714969,0.02628545,-0.031960674,-0.038651444,-0.0011966727,0.0077213277,0.009650393,0.068367,0.07010089,0.0047367103,0.037196588,0.048997924,0.0005704505,0.060715955,0.110911936,0.034663383,-0.03286213,-0.042654675,-0.04936916,-0.028727937,0.03968848,-0.033757206,-0.05546934,-0.022290453,-0.009733141,0.10476862,-0.040989358,0.013316862,-0.003527903,0.09448561,0.013021407,-0.04742711,0.017239932,-0.04932863,-0.044843707,-0.06353236,-0.017001947,0.006218938,-4.321334e-08,-0.0008685496,0.0069670775,0.013148994,-0.051824037,-0.011250698,0.08935378,-0.0418764,-0.104313575,0.03421689,0.022357551,0.021183679,0.030339798,0.055189382,-0.046738707,-0.011279167,0.0014857942,-0.036923293,-0.0037483096,-0.0029393402,0.06039204,-0.028569352,-0.012001858,-0.018260766,0.06917489,0.0467015,-0.05509293,0.008594851,0.0752754,-0.021970332,-0.011330636,-0.068406984,0.022715686,0.07263225,0.0061309948,-0.08381527,-0.011914201,-0.004103043,-0.025880953,-0.091066614,-0.025097232,0.053949285,-0.030403316,-0.03296187,0.013281964,0.026550254,-0.065864824,-0.007865256,0.079695396,-0.003106897,-0.0047690026,0.0058717676,0.0059710946,0.009682615,-0.0032577664,-0.033126388,0.052109066,-0.047951076,-0.013760567,-0.004360845,-0.004084684,0.02091116,-0.0033285061,0.075588346,-0.11135472 +2.1.1.376,"The enzyme, which catalyses the transfer of a methyl group from glycine betaine to a glycine betaine-specific corrinoid protein (MtgC), is involved in methanogenesis from glycine betaine in some methanogenic archaea, and in glycine betaine degradation in some bacteria. Unlike similar enzymes involved in methanogenesis from methylated C1 compounds, this enzyme does not contain the unusual amino acid L-pyrrolysine.",384,1.0,-0.06377406,-0.04330813,-0.089758866,-0.024604632,0.0906481,0.0555666,-0.059647933,-0.0020717948,0.0046868687,-0.033201575,-0.0058713267,0.01492286,-0.017163614,-0.009540209,-0.072241314,0.018534487,-0.02973673,-0.0034669621,-0.00717454,-0.033859182,0.013392734,0.06609456,-0.09026254,-0.01144834,-0.010356368,-0.0068541127,0.024816198,-0.007242586,0.020486807,0.0036907895,0.0103715,0.012838596,0.02933474,-0.025045155,-0.0024385105,0.16314621,-0.023875477,-0.0885892,0.07159568,0.02658452,0.051208183,0.034831785,0.09881911,-0.006932643,-0.0072537567,-0.010875629,0.032524157,0.031778425,0.0035461632,-0.07691925,-0.04220449,-0.078366734,-0.052969467,-0.002397457,0.013473319,0.05697087,-0.08922429,-0.0549213,0.048439037,-0.013442564,-0.017384717,0.049391873,0.019884333,-0.018501779,0.077944726,-0.046837635,0.03540328,-0.0957878,0.10470075,-0.054099575,-0.040747494,-0.016676761,-0.05264394,-0.06848333,-0.055001725,0.0340778,-0.053656846,-0.029109431,0.03481747,-0.10758624,-0.014467077,0.0038099755,0.02131297,-0.05301651,0.000837534,0.0018465375,-0.004953433,0.045776222,0.019106917,-0.020930042,0.08623195,-0.005715354,-0.0004440339,0.0027707864,-0.09164748,-0.032152362,0.08076714,0.0011125846,-0.015170629,0.0020434859,-0.050600152,0.11200439,-0.074835114,0.008843398,-0.07642537,-0.03459567,0.07355443,0.11541676,-0.047316138,0.057838194,-0.0117857065,0.07665847,0.03848047,0.019403866,0.01228819,0.052346874,0.042670008,-0.03897053,-0.071925454,-0.012305016,0.014474854,-0.028437687,0.06446209,-0.008654468,-0.04681816,0.068449005,-0.06480295,4.4708587e-33,0.10422162,0.040337656,0.029123569,-0.031271417,0.03275819,-0.01503676,-0.08986189,-0.0009508376,0.056958,-0.031591654,-0.03678634,-0.013146126,0.015478145,0.017338661,-0.04686865,0.05210304,-0.04323612,-0.032501478,0.06529642,-0.013801065,-0.040580865,0.058050655,0.0033825815,-0.0050296024,0.04946971,0.032267213,0.00013790987,0.011688523,0.040659286,0.018645462,-0.014273271,-0.09068709,-0.13734117,0.00779715,0.056490228,0.012863886,-0.10139871,-0.059305564,0.042840924,0.04613005,0.0047496017,-0.03279979,-0.006750214,0.012296248,0.014438805,0.026411379,-0.028279351,0.08123063,-0.046729647,-0.009558083,0.040073104,-0.015244966,0.04468217,-0.057191264,-0.10212713,0.0045080767,-0.017909959,-0.054845333,-0.011572656,0.13070492,0.026100865,0.06264234,0.0037291818,0.044009164,0.026644856,-0.033775188,-0.05372294,-0.058942597,0.07771174,0.041795477,-0.0049183946,-0.07791164,0.07356701,0.08451267,-0.008758408,-0.079268746,0.009760659,-0.044262744,0.028626602,-0.057518438,0.025366032,0.0046862746,0.033804912,-0.074908696,-0.0025356417,0.05390859,0.0018763181,-0.106901854,-0.008033357,-0.009814605,-0.006510115,-0.018462215,0.0007022814,0.017583188,0.0006169441,-5.1212362e-33,0.060833916,-0.10242821,0.04450308,-0.07933431,-0.07099429,-0.004824591,0.012121155,-0.07397244,0.03558484,-0.050585475,0.07693975,0.026452282,0.009912571,-0.06356551,0.05162013,-0.053925235,0.004627353,0.07515786,-0.057437,-0.029380724,0.060123015,0.008293199,-0.03106799,-0.054764513,0.026017062,0.026622552,-0.035975207,0.07739159,0.060285173,0.04939375,0.036813226,0.04653514,-0.050787423,-0.050527442,-0.07202068,0.0361657,-0.04445489,0.037318174,0.023018857,-0.029006394,0.06169451,0.071796134,0.0091228355,0.020635543,0.079707354,0.07321368,-0.0535514,-0.0028245708,0.029273892,-0.041196737,0.03350643,-0.046038777,-0.03159355,-0.011242846,0.046292655,0.09284587,0.021800607,0.01620041,0.017747488,-0.06436678,-0.007724966,-0.06041895,0.004222799,0.009146923,0.09989532,0.04525311,0.07111287,0.017213352,0.08824343,0.015884694,0.04977134,0.034819663,0.049883213,0.034766894,-0.03729806,0.025699623,-0.1155906,-0.00672368,0.0047500003,-0.05885207,-0.0065641166,0.0009875026,0.02886185,-0.041538313,-0.013550926,-0.097630076,0.06747455,0.115140736,0.02253614,0.014729551,-0.07873223,-0.07510748,-0.0527816,0.0040389355,0.06082853,-3.6354457e-08,0.07017276,-0.031846892,0.034386743,-0.048182067,-0.008940539,0.079956576,-0.014936206,-0.0163076,0.06717448,0.0056074015,-0.1031917,0.024082478,0.0243647,-0.011678783,-0.09147112,0.1266704,-0.06825694,-0.0033180958,-0.0315768,-0.018899791,-0.07164943,0.01924396,-0.03746964,0.08490389,-0.01801124,-0.05294205,0.03767099,0.13086288,-0.02748309,-0.05013074,0.019226069,0.017610224,0.066806965,-0.028062468,-0.05367956,-0.0004249052,-0.008589328,0.001187686,0.03690646,-0.02323797,-0.016220335,-0.00030720464,-0.05858404,0.02507761,0.03265434,-0.020960161,-0.019045223,0.07808798,-0.07354102,0.04831771,0.06609545,-0.0011335287,0.0057258406,-0.06305931,-0.08278617,-0.03435897,-0.054330606,-0.054677803,-0.007892459,-0.069646895,0.0059005944,-0.016812017,0.14603674,-0.06115548 +2.1.1.377,"The enzyme, which is involved in methanogenesis from glycine betaine, catalyses the transfer of a methyl group bound to the cobalt cofactor of glycine betaine-specific corrinoid protein to coenzyme M, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, which catalyses the final step in methanogenesis. The enzyme from the methanogenic archaeon Methanolobus vulcani B1d can also catalyse the activity of EC 2.1.1.246, [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase.",384,1.0,-0.046440188,-0.0135001475,-0.09291733,-0.018231632,0.077536635,0.050169963,-0.12458058,-0.0023476994,-0.0031400083,-0.05907582,0.0013369913,-0.046804383,-0.031856846,-0.05046069,-0.021198332,0.058573246,-0.03967714,-0.0059370883,-0.030466797,-0.029073762,0.061875276,0.04236335,-0.03468492,-0.006488959,-0.050419386,-0.015442328,0.063485995,-0.01606906,0.050745036,-0.0040626787,0.036123913,-0.03173663,0.029495412,-0.027840937,0.033822652,0.08817019,0.03847035,-0.1248336,0.04705925,0.025149906,0.022120973,0.053725053,0.031402923,-0.055580027,0.030248785,-0.03060383,0.03941294,-0.011398004,0.030340899,-0.10750517,-0.04564377,-0.06234082,-0.02140875,-0.0102013815,0.03809979,0.07226276,-0.08151276,-0.012310211,0.07879227,-0.035350066,0.045641735,0.020127214,0.07117283,-0.021417012,0.0011016062,-0.0047880663,0.035447344,-0.082621925,0.101340935,-0.04236355,-0.092021056,-0.018756032,-0.08674576,-0.03454173,-0.04755673,-0.00030428517,-0.049478497,-0.051695194,0.083562404,-0.033700693,-0.03893006,0.005778044,0.021561317,-0.07388592,0.02405762,0.003973059,-0.023126427,0.027863618,0.010048175,0.051759154,0.013059095,-0.06703127,0.03246158,0.01969033,-0.06728783,0.0010556829,0.09818944,0.082765706,0.036942814,0.0065999622,-0.047390476,0.13097887,-0.098168306,0.027467767,-0.05936177,-0.04087694,0.09916077,0.13546939,-0.010377306,0.070438914,0.03434191,-0.009001371,0.07124318,0.0037641372,-0.0155164,0.104547486,0.01980039,-0.05165898,0.01740577,0.001341791,0.0908251,-0.006599435,0.048579387,-0.01720198,-0.039338928,0.054445803,-0.09148696,4.7521578e-33,0.10683391,0.07415819,0.007890853,0.018957442,-0.029797258,-0.03365696,-0.14243205,0.08446464,0.03402725,-0.038732335,-0.07282111,0.00686896,0.044273328,0.020051558,-0.03965631,-0.013761126,-0.0045937793,-0.059376333,0.053804617,0.010181329,-0.051675756,-0.03025838,0.0078063947,-0.035555452,0.039268035,-0.029440632,-0.010257305,0.033334173,0.07221616,0.0069840807,-0.06601013,-0.07583378,-0.07921454,0.021958206,0.0054155327,0.0121004665,-0.06524213,-0.031707767,-0.010829795,0.0136771295,0.08329245,-0.022700936,0.0017260438,-0.025049562,0.032070484,0.042177644,-0.03999897,0.055030875,0.08016697,-0.031007932,-0.027967153,0.025070366,0.051886145,-0.048229367,-0.043565918,-0.041322574,-9.626721e-05,-0.070098564,-0.010238153,0.09299976,-0.06332316,0.038301878,0.040288948,0.08200574,-0.037758872,-0.010067216,-0.10744578,0.010888417,0.018109862,0.018864391,-0.022911297,-0.022521295,0.053880025,0.055326436,0.022064958,-0.06737168,0.0545342,-0.034927536,0.056414567,0.0032838492,0.04151702,0.046525657,0.0021735139,-0.04795732,-0.0055479743,0.028397458,-0.023259215,-0.057789817,0.04636622,0.04253042,-0.040539484,-0.07096066,-0.000532542,0.04837745,-0.00041160427,-5.3071792e-33,0.06142114,-0.071669206,0.013390112,-0.14555481,-0.061455175,0.037505873,0.036453277,-0.07772981,0.04168238,-0.06414566,0.09026772,0.002189451,0.070327125,-0.026011731,0.045111656,0.003365768,-0.007834356,0.075074874,-0.010967673,-0.020153567,0.057025373,0.0397245,-0.029421704,-0.05608886,0.017785119,0.0195403,0.005574086,0.044234127,0.047886673,0.10383944,-0.0022572828,-0.007971825,-0.07062748,0.007498137,-0.115805216,0.05732146,-0.058769796,-0.016530957,0.009537185,-0.032151174,-0.011820943,0.0258469,-0.04567009,0.03412516,0.0970015,0.1022268,-0.014625897,-0.03358949,-0.0051382342,-0.036787562,0.025166402,-0.041927632,-0.07144351,0.0005962762,0.013512524,0.081347115,0.021397728,0.045028694,0.039156124,-0.061677266,-0.011905616,-0.008825619,0.028830742,-0.050727114,0.051171247,0.026069865,0.015405955,0.033882204,0.051773556,0.03949665,0.042955674,0.052777473,0.032346644,0.037831463,0.0030302359,0.0042703403,-0.1290371,-0.015243377,-0.04537064,-0.040616192,-0.023531947,0.0095666135,0.047016263,-0.034281977,-0.018905908,-0.049549386,0.056512628,0.07129288,-0.024509598,0.030950189,-0.09167629,-0.035982393,-0.051657777,0.039391156,0.03810978,-4.1553673e-08,0.012013209,-0.039402105,0.043659575,-0.05675596,0.0075867716,0.094339326,0.0053270576,-0.030950522,0.0076115658,-0.030572318,-0.067713104,0.020261705,0.030757,0.016184265,-0.08005392,0.05200457,-0.08509991,0.014125938,0.0043050474,-0.008450383,-0.021791875,0.011539876,0.011699935,0.050568998,-0.02557839,-0.0996322,0.049792442,0.11429439,-0.04178421,-0.09218609,-0.0154610565,0.033174768,0.01876831,5.2372525e-05,-0.075828224,-0.024638683,0.0005125011,0.02872728,-0.0323095,-0.0022091893,0.024513451,-0.04174174,-0.08133771,0.051534876,0.07169103,-0.041411523,-0.025668047,0.08960548,-0.04653286,0.011691222,0.07055265,-0.04040457,0.04133871,-0.06564788,-0.050084583,-0.053077716,-0.07694799,-0.03695793,0.007087194,-0.026100302,0.019561777,-0.011179168,0.11869868,-0.101183884 +2.1.1.378,"This enzyme, characterized from the anaerobic bacterium Desulfitobacterium hafniense Y51, catalyses a similar reaction to that of EC 2.1.1.258, 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase, but in the opposite direction, transferring a methyl group from a methylated corrinoid protein to tetrahydrofolate. The corrinoid protein is specifically methylated by EC 2.1.1.376, glycine betaine---corrinoid protein Co-methyltransferase.",384,1.0,-0.0050301477,0.028841134,-0.1852517,-0.04803625,0.055661384,0.020096295,-0.099519454,0.027737807,0.004502883,-0.058982104,0.028609237,-0.07616738,-0.065372616,-0.05531803,-0.017240679,0.0018677068,-0.04194671,-0.029002488,0.011160035,-0.058974206,0.05639701,0.03644701,-0.077779494,-0.037011478,-0.021588596,0.09185904,0.0029372445,0.02954369,-0.038277987,-0.07496221,0.05090966,-0.013463004,0.0021103316,-0.02488461,0.028856667,0.092519805,-0.02531051,-0.114608526,0.07418233,-0.0016912008,0.03146738,0.053795155,-0.008785588,-0.015266786,-0.016569903,-0.012768681,0.0015385039,0.07377385,0.043178886,-0.08763764,-0.06730967,-0.03950726,-0.013976658,0.013160281,0.02792664,0.033990853,-0.017975915,-0.061146602,0.04349878,-0.019736897,0.03146351,-0.018088913,0.054021336,-0.016281186,0.01871783,-0.05020597,0.05010567,-0.14670187,0.053855967,-0.060914952,-0.113308996,-0.03243341,-0.026221672,0.017555732,-0.047419053,0.035809718,-0.01813739,-0.022152018,0.08697806,-0.050576456,-0.024031363,0.015987327,0.027048947,-0.015837787,-0.0026073605,-0.047907107,-0.051284265,-0.005696399,0.05941135,0.08535847,0.048874155,-0.004227099,0.06861867,-0.011366107,-0.07423108,0.045278445,0.030515846,0.12975892,0.010436489,-0.028355248,-0.05961403,0.11392208,-0.04957814,-0.042987484,-0.0064082947,-0.029519873,0.088840015,0.15284476,0.0008359497,0.0027113773,-0.058498815,-0.02169578,-0.004074243,-0.05167217,0.021727618,0.10505902,0.07076006,-0.045026932,-0.043240145,-0.056800283,0.08144548,-0.03659979,0.018774284,-0.03276137,-0.005642009,0.053432442,-0.15776311,3.4822205e-33,0.1213859,0.09050524,0.023899743,0.0055417963,-0.009659568,-0.017347164,-0.12156459,0.08476768,0.053127613,-0.056755144,-0.102364875,-0.02190379,0.049854178,0.0045805317,-0.055281244,-0.031830754,-0.03368545,-0.005914581,0.037957266,0.01368397,0.022923773,0.07453412,0.0038403799,-0.053745918,0.051440552,0.04708738,-0.013656281,-0.019273069,0.056276765,0.026981628,-0.008034871,-0.13416341,-0.08880085,-0.022873616,0.10769203,-0.01775871,-0.06044968,0.047451966,-0.024120059,0.03510809,0.026561355,0.041971497,-0.0059546973,-0.022019463,-0.003680839,-0.038738653,-0.0076587927,0.030973647,0.05545617,0.026436755,-0.007327197,-0.024629246,0.09334576,-0.053799305,-0.045514073,0.014667397,0.04144411,-0.009440125,0.0006408705,0.055384144,-0.0011886623,0.07033681,0.0061370935,0.005103187,0.014375934,-0.032932077,-0.033775993,0.0053271404,0.05933856,0.04127737,-0.028347792,-0.039977167,0.14012945,0.016608577,0.014329994,-0.049949314,-0.040566787,-0.073806584,0.049645245,-0.009067768,-0.021608628,0.031623803,0.043749172,-0.08895473,0.0066283396,0.038198367,-0.07549024,-0.046826966,0.00933913,0.023968581,-0.027651837,-0.027076095,-0.016919773,-0.03202952,0.01542713,-4.5931424e-33,0.043297995,-0.083892055,-0.0196424,-0.08134066,-0.037571512,0.084254034,0.005096107,-0.0049395394,-0.029313896,-0.012908078,0.12821834,0.0032161078,0.036528114,-0.076047994,0.06508465,0.006467567,-0.0071959845,0.053770956,-0.040551882,-0.019019792,0.061987247,0.028091805,-0.016352206,0.012347922,0.018178582,0.034116525,0.026364796,0.032490928,0.07671687,0.03840367,-0.018499989,-0.0142026255,-0.034367234,-0.02750108,-0.038228087,0.05134397,-0.04141781,0.028488731,0.0022430157,-0.027973993,0.008847218,-0.010478253,-0.0006979167,0.07511193,0.03686401,0.060849726,-0.056914072,-0.015699156,-0.010246983,0.059301395,0.036378972,-0.0137764765,-0.07591273,0.06254346,-0.0038999387,0.040824194,0.009270215,0.06684936,-0.057669435,0.022256726,-0.043277882,-0.024032239,-0.0065968623,-0.02277867,0.07211351,0.05580017,-0.017181097,0.02308461,0.045074474,0.0016503666,0.029812397,0.018969174,-0.043342743,-0.016236043,-0.02077113,-0.05171104,-0.092139006,0.009238142,-0.0371548,0.021565748,0.022646008,0.0022925108,0.022272924,-0.03371859,0.03376703,-0.06017746,0.025311902,0.07284046,-0.06826937,0.045227446,-0.025543809,-0.045445584,-0.09494825,0.073227644,0.0003571456,-3.8885048e-08,-0.020889884,-0.05004105,0.05153198,-0.0080666775,0.04634072,0.09060931,-0.09223525,-0.06427462,0.020347502,0.012918446,0.042500697,0.029732741,0.011519909,0.027936079,-0.035765063,0.03493401,-0.05082657,0.024406238,0.020359172,0.022875693,-0.027353304,-0.012987952,-0.08912263,0.05504673,0.073222175,-0.06509636,-0.007311109,0.034064177,0.0010633824,-0.029043283,-0.025180256,0.03879463,-0.03243569,0.010452669,-0.047972117,-0.031462885,-0.013896542,-0.063290946,-0.049601033,0.019037755,0.03697531,0.052517824,-0.10870829,0.061614465,0.05002737,0.037809234,-0.0051585417,0.065648176,-0.07386588,0.01466851,0.041206893,-0.03885495,0.025544133,-0.035620585,-0.10295315,0.020841192,-0.032266144,-0.074497305,0.00025015738,0.040279705,0.08138201,-0.019519353,0.14109452,-0.026576504 +2.1.1.379,"The enzyme, present in methanogenic archaea, catalyses a modification of an L-arginine residue at the active site of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase (better known as methyl-coenzyme M reductase), which catalyses the last and methane-releasing step of methanogenesis. The enzyme is a radical AdoMet (radical SAM) enzyme and contains a [4Fe-4S] cluster and a Coalpha-[alpha-(5-hydroxybenzimidazolyl)]-cobamide cofactor. The methyl group, which is derived from S-adenosyl-L-methionine, is transferred to the cob(I)amide cofactor, forming methylcob(III)amide as an intermediate carrier, before being transferred to the arginine residue.",384,0.99999994,0.0049137603,-0.06333051,-0.11514633,0.0013559035,0.10107519,0.046900205,-0.09126589,9.505601e-05,-0.020097734,0.013779263,-0.020567847,-0.05497665,-0.036652923,-0.014527246,-0.038195472,0.082514994,-0.07992228,-0.044045,0.030033845,-0.031767998,0.052412894,0.07065434,-0.028429583,-0.025577663,0.006963921,0.028788801,0.040854044,-0.053846706,-0.0069891876,-0.040729012,0.037868205,-0.034773115,0.055373203,-0.034281228,0.060205486,0.119449556,0.010767967,-0.055538505,0.069992624,0.031700294,0.014950325,0.021299396,0.07739903,-0.027860735,-0.03140547,0.022101104,0.055155013,0.012227667,0.020214124,-0.09491552,-0.04133973,-0.031632967,-0.073101595,0.054803275,0.010500307,0.098692,-0.0169634,-0.06558807,0.031087322,-0.026149144,0.062862694,0.013976431,0.017003128,-0.031615745,-0.017212026,-0.02156658,0.09091996,-0.094005555,0.126182,-0.016523285,-0.07330616,-0.006673115,-0.07025045,-0.044973917,-0.0597741,-0.019742768,-0.0023963733,-0.043479707,0.104312435,-0.026633302,0.012658537,0.015101481,0.045184992,-0.05939303,0.03190244,-0.027616328,0.010142709,-0.018296313,0.09327909,-0.018747378,-0.012833373,-0.038585268,0.029001266,-0.016659796,-0.08991157,-0.07035635,0.082605086,0.07438984,0.021833178,0.0015529701,0.0016868034,0.07576651,-0.117879815,-0.046870295,-0.07486921,-0.055270176,0.049123723,0.18377039,0.033323977,0.08044574,0.03662137,0.045113362,0.086653106,0.015156394,-0.01684654,0.08336158,0.037961602,-0.09836526,-0.06595178,0.03154368,0.0211061,0.006262092,0.10514148,-0.018053189,-0.050994556,0.001509595,-0.1511413,3.7632313e-33,0.07892766,0.06271868,0.0100443605,-0.0012644745,0.008802907,-0.034984,-0.11431298,0.019947892,0.01729052,0.0049336036,-0.044034347,-0.03032843,0.08511164,-0.00435258,-0.10060727,-0.050366633,-0.033305153,-0.051170338,-0.0009291326,0.0022481715,-0.09251013,0.039431144,-0.013410757,0.017388556,-0.005068942,-0.022237118,0.029935896,0.009813756,0.055188205,0.029177321,-0.06015046,-0.06674606,-0.123638876,-0.019964755,0.042528898,0.010910053,-0.066672504,-0.050292887,-0.022562314,0.033486426,0.0027618827,0.014478787,-0.00030772205,-0.056742664,0.052174434,-0.0027369321,-0.061828345,0.1363706,0.024811301,0.029744979,-0.03128361,-0.03450696,0.06906862,-0.0153731285,-0.102280244,-0.032331474,-0.010019604,-0.044583745,0.04377916,0.08072987,-0.012095444,0.009619335,-0.0080630435,0.09121129,-0.039483927,0.009693738,-0.0098280525,-0.01481036,0.04502379,0.09109231,-0.0026355968,-0.0070587606,0.048744544,0.06651382,-0.006843371,-0.07134089,0.0072078127,-0.0035868713,0.028040381,0.034194086,0.019614527,-0.017746814,0.027815139,-0.045898654,-0.0090089375,-0.018929847,-0.032776892,-0.026707858,-0.0036705679,0.03980511,-0.0105517795,-0.06867191,0.014285944,0.050649934,0.009858356,-3.8288665e-33,0.07739326,-0.059171293,-0.0066831694,-0.14248362,-0.07118645,0.05303422,0.08386346,-0.038349614,0.00952824,-0.07519223,0.09442081,0.030370291,0.036030427,-0.021297984,0.07039755,-0.06966288,0.02717539,0.009214726,0.029548144,0.030978588,0.08710653,-0.00041827094,-0.084993064,-0.025865924,0.025821446,0.009545001,0.0041773813,0.045838293,0.043475457,0.04722579,-0.0068593114,-0.013510243,-0.057641108,-0.018527582,-0.090312816,0.052211657,-0.058235124,-0.024042673,-0.031454988,-0.024801422,0.025332512,0.06026533,-0.005595922,0.070885144,0.05277342,0.0551744,-0.087951355,0.007175452,0.010561645,-0.07994157,0.012968264,-0.112833,-0.0089062415,-0.066987164,-0.018012172,0.07186063,0.01370423,0.007602319,0.0005718042,-0.008065339,-0.0343168,-0.03131292,0.035944805,-0.025554338,0.041170303,0.0054448065,0.006583182,0.0066955807,0.018942663,0.0008977147,0.015217274,0.02649529,0.02100038,0.07965296,-0.049109314,-0.033076525,-0.074213095,0.0032226972,-0.008924183,-0.0500235,0.0217214,-0.04152123,0.049728476,-0.054127313,-0.0042924816,-0.06674814,0.054996766,0.044903185,-0.014308167,0.03352372,-0.099336565,-0.0069517847,-0.030883659,0.022861144,0.035443563,-4.9371376e-08,0.029874614,-0.048539206,0.036440622,-0.0038825537,0.0052581322,0.1391303,0.011251648,-0.029710239,0.034904853,-0.052695878,-0.0019513923,0.0579425,0.041272093,0.045312878,-0.04918516,0.056819014,-0.07320262,-0.027676651,-0.010111007,-0.029540088,-0.05238884,-0.032577664,0.0044374545,0.045812994,0.01303545,-0.043272447,0.061058555,0.11956293,-0.03193445,-0.063891985,-0.0046196473,0.024047606,0.026632298,0.030127447,-0.0835098,0.013441787,-0.03217887,-0.020012677,-0.0096564675,0.050895985,0.040996466,0.037985153,-0.06637823,0.039255522,0.03503425,0.0004461798,-0.04667229,0.044595495,-0.018912902,0.017939217,0.06667129,-0.017619146,0.020496227,-0.03291403,-0.043048624,-0.015564378,-0.04554985,-0.04440082,0.03661132,-0.002862181,0.05766827,-0.009665871,0.09556461,-0.052502606 +2.1.2.14,"The enzyme, characterized from the bacterium Brucella melitensis, synthesizes a building block of the O antigen produced by Brucella species.",384,1.0,-0.052834548,0.007324334,-0.12857485,0.043180373,0.0049420656,0.02286182,-0.024773933,0.027869813,0.0039962623,0.0056346245,-0.031444136,-0.11726943,-0.0013153948,0.0031148486,-0.062820725,0.14957997,-0.015415108,0.024675386,0.0119903125,-0.017426185,0.03777023,0.037663653,0.008148222,-0.0028981662,-0.059568636,-0.0009907776,0.029541714,0.02188491,0.035260275,-0.12644573,-0.043398187,-0.05358312,0.13016693,-0.04735829,0.087733984,-0.07050028,0.09628771,-0.023294259,-0.06402313,0.011640341,0.017532289,0.04689583,0.032059256,-0.029684193,0.02099282,0.010643876,0.07050358,0.0364594,0.034552842,0.022311794,-0.091195755,-0.059855267,-0.09593218,0.028971406,0.028491117,0.004098959,-0.058030844,-0.11198672,0.009429068,0.024044242,0.01917836,0.018420214,0.034256443,0.033272665,0.07223975,-0.044329066,-0.04850993,-0.050937016,-0.032212842,-0.09256434,-0.057074167,-0.1132268,0.015303507,0.06550921,0.009835199,0.07015852,0.070893,-0.0035833416,0.04984198,0.0360059,-0.015785957,0.007996956,0.006414567,0.059465103,-0.011439476,0.043989554,0.049946986,-0.010638852,0.06781849,0.03633526,-0.011643258,-0.06260758,-0.009641523,-0.06377306,-0.003384589,-0.037964944,0.053036068,-0.0018687308,0.08441243,0.035421308,-0.06903452,-0.04379164,0.013292729,-0.07415502,-0.05108793,-0.05790426,-0.0007248985,0.08800235,0.012450191,0.027031677,0.069446735,0.024948163,-0.05450706,0.010985074,0.0008419669,0.0018155493,0.051695082,-0.056171183,-0.08677654,0.012260984,0.03690129,-0.013124545,-0.012611555,0.046175234,0.004274421,0.041113358,-0.04493555,-1.2432099e-33,0.046165407,0.029104227,-0.006914097,0.002004715,-0.004440246,-0.032927737,-0.016873855,0.00484024,-0.026882496,-0.040375575,-0.05063659,-0.04546294,0.05514976,0.039011177,0.055241905,-0.04093249,-0.0034644923,-0.044570226,0.0090954825,-0.026386105,0.008723204,0.087383784,-0.053056013,-0.003523443,-0.006094557,0.03612925,-0.0083439,-0.018215135,-0.0037914389,-0.030356152,0.030430363,-0.03449128,-0.105247356,0.02533171,0.107092366,0.02498549,0.05265925,-0.06033479,-0.00068331754,0.024378479,-0.008555509,0.022893041,-0.027066555,0.0071852254,0.087697215,-0.093591675,-0.087086804,0.006601492,0.061936274,0.042068496,0.012034429,-0.0058511533,0.066401444,-0.0022705533,-0.09982549,0.043526497,-0.07036776,-0.008629748,0.038216628,0.040419757,-0.018212799,0.03148108,-0.031757712,0.015508058,-0.025836706,-0.040621493,-0.0008943196,-0.017654829,0.032567464,0.036600642,0.010279372,-0.0069210967,0.0316219,-0.03248356,-0.039934002,-0.027778868,-0.042446468,0.071435556,0.046864536,-0.039075773,0.042543735,0.003525875,-0.015332802,0.010884592,-0.04750134,0.008011214,-0.055619083,0.02881247,-0.049320977,0.022002414,0.096385665,-0.034236796,-0.05159721,0.015175474,-0.025348278,-5.7658622e-34,0.11128217,-0.10867687,0.062343817,-0.03645298,-0.075411834,0.0023707151,-0.026368124,-0.008124381,-0.06381796,-0.056013502,0.03673507,0.04858063,0.09434828,-0.046036303,-0.035396386,-0.05536079,0.01967538,0.086287804,-0.012348614,-0.02439461,-0.05401537,0.008771142,0.039321154,-0.13429043,0.0061633773,0.037340146,-0.02067843,0.097018436,0.07275062,0.038189363,-0.040930565,0.026830599,-0.018808214,-0.08082646,-0.037536994,0.05373689,0.020160751,0.004759717,0.061656576,-0.004764881,-0.031050373,-0.007888617,-0.064617485,0.05593979,0.081888564,0.13911496,-0.008260045,0.03189644,0.051180623,0.027134305,0.11805649,-0.0028348698,0.006315932,-0.05191163,-0.05129357,0.0025379434,0.05285181,-0.07002426,-0.017591896,-0.021170639,-0.014386862,-0.026589155,0.08941232,-0.0068809413,0.01687485,0.12975278,0.016090995,0.062732965,0.0022650457,-0.022682436,0.0057680923,0.06428602,0.014396332,-0.014870973,-0.023435388,0.0106877545,-0.031064728,-0.0411741,0.0036004896,0.04214069,-0.055719264,-0.013914945,0.060524594,0.057320736,0.014478527,-0.023757676,0.04126968,0.01501017,0.0148746,0.034310408,-0.045103654,-0.027202908,-0.058917556,0.039421048,0.01599529,-2.5816009e-08,-0.014691095,-0.10664011,-0.0014206223,-0.06997545,0.007978772,0.10774901,-0.09088144,-0.07071482,0.10043082,-0.02304912,0.020341955,0.091932476,-0.042018376,0.005915419,0.051511783,-0.0027394732,-0.023054387,-0.08549578,-0.014489339,-0.047687482,-0.06670738,0.009533165,-0.041179538,0.09717742,0.0026174397,-0.04825204,-0.039181475,0.0017358093,-0.008920488,0.0022135049,-0.039982233,0.090948135,-0.05031766,-0.0044236346,-0.07691316,-0.055399537,0.0102349045,-0.044367734,-0.0007514587,-0.004817404,0.078533486,0.01088395,-0.05987687,-0.0019794893,0.03218902,0.029059395,-0.0775874,-0.004325338,-0.06488517,-0.070168845,0.06214847,-0.014568885,0.011606488,-0.007838092,-0.12839207,-0.035473112,0.024246207,-0.11625203,0.026176557,0.053171903,0.009889143,0.009274891,0.19402081,0.0064723413 +2.4.1.384,"The enzyme, characterized from the bacterium Bacillus licheniformis DSM-13, is an extremely promiscuous glycosyltransferase. It can accept ADP-, GDP-, CDP-, TDP-, or UDP-activated glycose molecules as donors, and can glycosylate a large number of substrates, catalysing O-, N-, or S-glycosylation. While D-glucose is the primarily reported sugar being transferred, the enzyme has been shown to transfer D-galactose, 2-deoxy-D-glucose, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, L-fucose, L-rhamnose, D-glucuronate, and D-viosamine.",384,1.0,-0.071190625,-0.048121847,-0.12407537,-0.011600232,0.0052158292,-0.016387153,-0.026413519,0.05086114,-0.007293231,0.021953499,0.010065661,0.059695218,-0.05213035,0.01986291,-0.08497148,-0.012345177,0.046522032,0.0073902565,0.010127861,0.042748023,0.113069594,0.026305525,-0.009241104,-0.023850383,0.0864382,-0.042050984,0.043255005,-0.081553824,-0.047883835,-0.056471996,-0.08167735,-0.062017005,0.03521545,-0.022349248,0.04514855,0.08693446,0.0014723213,0.014811098,0.051866964,-0.040089484,-0.026435155,-0.01244808,0.03335172,-0.042634293,-0.08341502,-0.029750438,-0.022354193,0.049209274,-0.008245202,-0.00065239664,0.03165263,0.0036126,-0.039384637,0.029036732,0.042834815,0.043434244,-0.03693067,-0.027961029,0.015751634,0.009449755,-0.01269213,0.059226472,0.041757107,0.006320319,-0.043587267,-0.10181226,0.083069734,-0.017188333,-0.049007922,-0.016992375,-0.0496632,-0.029422728,-0.0270862,-0.024646942,0.087852135,0.00772301,-0.030986931,0.013879175,0.06599527,-0.010269163,0.06727894,-0.0007171131,0.056186825,0.06981585,-0.05968897,-0.03201598,0.010025627,0.08750666,0.036046498,0.002951055,-0.015416964,-0.028679801,-0.016140468,-0.04894538,-0.061687592,-0.039002903,0.05004096,-0.010007949,0.0578969,-0.017322145,-0.032257278,0.048024002,0.07093078,-0.06676788,-0.063045256,0.0325476,-0.007560845,0.08295409,0.12117506,0.0013805175,0.013949917,0.11968738,0.07926321,0.0010187527,-0.08092482,0.032266565,-0.054965056,-0.08841475,-0.057619482,-0.026814755,0.026431838,0.0038656006,0.05153441,0.02686769,0.022958076,0.062205177,0.03473336,8.117589e-34,0.0619842,0.019110126,0.018452859,-0.02580202,0.0011914738,0.0031738426,-0.029189022,-0.02750302,-0.033926602,0.016666645,-0.12396342,-0.06199375,0.016909078,0.17261785,-0.005267105,0.14130764,0.051052894,-0.053069875,0.09588899,0.012104889,0.038003407,0.055367876,-0.021266535,-0.020121427,0.08162211,0.08732285,0.007534114,0.09367682,0.073215745,-0.019064788,0.03943264,-0.113036744,-0.017254835,0.016733004,0.051348485,0.06494201,-0.037837274,-0.028130652,0.03939335,-0.005943909,0.051322818,0.031027298,-0.020811586,-0.011884539,0.0027903828,0.0826477,-0.010182564,-0.026069243,-0.036598478,0.1182551,0.021189153,-0.050989714,-0.0012838346,-0.023176307,-0.057330728,0.062178373,-0.015886705,-0.02516853,0.010773253,0.08627297,0.027423533,0.04359165,0.015395946,-0.011705773,0.015908703,0.013368823,-0.073751464,-0.004458492,-0.016873607,-0.015431339,-0.07965525,-0.052653853,0.06810823,0.018830389,-0.0011860217,-0.09048132,0.04392654,0.005520919,0.050737575,-0.05041459,-0.013017676,-0.0026468767,-0.017980326,-0.074335106,-0.019338813,0.025723157,-0.12621793,-0.09302346,-0.033219058,0.06440956,-0.06862915,-0.04222912,-0.09170026,0.026543694,-0.03757819,-3.781707e-33,0.09562258,-0.0875097,0.08344422,-0.034305185,-0.03825182,0.051401075,0.041285634,-0.006206683,0.005887105,-0.058141526,0.009520777,0.03429805,0.01664786,-0.014883416,0.036338437,0.023657748,-0.044590138,0.06341645,-0.06457991,-0.006644642,0.0020263772,0.1154874,-0.048674777,-0.033071443,0.042287737,-0.04266298,0.0045374148,0.079384126,0.03814049,0.03967589,0.07609392,0.014144199,-0.060471572,-0.0692434,-0.05058712,0.030739367,-0.039907757,-0.036098298,-0.045449328,0.00011178767,-0.0049376837,0.05718027,0.0140535,0.027726058,0.08001077,0.07673386,-0.09052857,-0.053773876,0.02827749,-0.036547452,-0.016242638,0.019580035,0.013293524,0.022418747,0.056691,0.049707808,0.048608378,0.0073918994,-0.02509019,-0.0792674,-0.046280686,-0.055189803,0.03487006,-0.0550765,0.05703283,0.06779469,0.012641979,-0.015443907,0.037188422,-0.01632099,0.040201593,-0.041788783,-0.020443844,0.03608314,-0.019888315,-0.008593904,-0.12541007,-0.009356463,-0.011283666,-0.0258187,0.0467677,-0.025819095,0.048173048,-0.023073297,0.034475315,-0.06730243,0.056920737,0.062585294,-5.0356604e-05,0.03881765,-0.07455372,-0.008601454,0.0006050441,-0.024821512,0.056552876,-4.8949108e-08,0.027221605,-0.03092754,-0.017747398,-0.04641111,-0.048758067,0.045218557,0.0039157216,0.021462938,-0.04218954,-0.07692863,-0.068597406,0.12042089,-0.07482451,-0.027361933,-0.03656265,0.020490678,-0.091096066,-0.012386156,-0.02545458,0.036431067,-0.13673677,0.004672869,-0.10496992,0.0499741,-0.0015356432,-0.046160575,0.0950104,0.025920356,0.028243372,-0.025227306,-0.01714729,0.053774334,-0.039802022,-0.005593219,-0.056917958,-0.07110041,-0.041951317,0.009300522,0.06095547,0.020668514,0.041669667,-0.0015807918,-0.049740013,0.017039698,-0.04551867,0.026459767,-0.02274963,0.0041678636,-0.05011048,0.053582385,0.028577657,-0.04629229,-0.086745374,-0.056824915,-0.05077272,0.00653441,-0.048924807,-0.03594427,-0.03538376,-0.007957487,0.01029256,-0.027052652,0.13975205,-0.063643225 +2.7.1.233,"The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose.",384,1.0,-0.010717851,-0.049822982,-0.011911123,-0.03040062,-0.017747216,0.00010416002,-0.07669161,0.02012189,0.035755288,0.07740424,-0.0058297324,-0.031696104,-0.042020656,0.082912594,-0.02210022,0.043449588,-0.084883094,0.031416588,-0.032128934,-0.009902853,0.10729442,0.052869167,-0.012106387,-0.06035086,0.03928096,-0.03481488,0.097833104,-0.022893658,-0.05446615,-0.046231274,-0.025056941,-0.046470374,0.03025056,-0.004232167,0.07550718,0.045013174,0.026931433,-0.037550174,0.06979521,0.0002979943,0.0018248165,-0.01211736,0.010437837,-0.014509574,-0.069328904,0.014629447,-0.07254768,0.020688102,0.012070894,-0.020146746,-0.051223747,-0.06265584,-0.038105544,0.007907252,0.046322744,-0.013994073,0.0018091127,0.01128746,-0.05245691,-0.062032823,0.068182275,0.01348,0.06940905,0.05410239,0.02082399,-0.040322073,0.009222289,-0.026207337,0.015828568,-0.081414975,-0.066444404,-0.10101094,-0.042791594,0.030849587,0.016673585,-0.031250432,0.044307943,-0.04927883,0.014138358,-0.094823495,0.047390208,0.055806044,0.024258235,0.10644971,-0.014648772,0.05180601,0.034623142,-0.037972912,0.042213142,0.013019836,-0.013808782,-0.06993193,-0.016979255,-0.086577676,-0.065138444,-0.018036421,0.0132194385,0.015465527,0.027334405,-0.0383427,-0.051050585,0.08654528,-0.02624758,-0.060548257,-0.05653179,-0.0024408116,-0.021349544,0.0729144,0.022864882,-0.03323822,0.03825701,0.021634515,0.069731735,0.078542136,-0.030713027,0.044235587,0.023645664,-0.050945632,-0.019512856,0.0149498535,0.004109745,-0.04993793,0.057325944,0.07167553,-0.044917382,0.03938547,-0.05100519,-3.9938695e-33,0.07701653,-0.023794277,-0.030638412,-0.011090716,0.054700103,-0.06879065,-0.048186816,0.012923736,-0.11778397,0.018220795,-0.15511115,-0.1007017,0.036854904,0.05468623,-0.0045858747,0.022027943,-0.014177172,-0.0036069485,0.020038193,0.019473074,0.020169104,0.053896114,-0.009435582,-0.023028785,0.02476515,0.06042219,0.012546169,0.09858029,0.01398474,-0.027254311,-0.006783864,-0.1024362,-0.037233513,0.02785199,0.026910445,-0.019657854,-0.0072459285,0.020525083,-0.018132523,0.024871124,0.024905136,0.04629143,-0.008859157,-0.023136783,0.0394961,-0.0012132374,-0.0339609,0.07268619,0.010438631,0.08632905,0.092489235,-0.020120462,0.12285258,-0.038176153,-0.05616376,0.0071428623,-0.05646787,-0.029924996,0.0164776,0.03078253,-0.00479683,0.037105337,-0.06625272,0.08103661,0.03915977,0.014263465,-0.014566244,-0.01851812,0.024279056,0.090695165,-0.1187731,-0.010497617,0.047585413,-0.04230578,0.040251736,-0.076674886,-0.039990775,-0.024372483,0.042019125,-0.02130802,0.0077507054,-0.03755073,-0.027281096,-0.015982693,-0.072845206,0.009274025,-0.059099857,-0.09926928,-0.09184678,0.013841298,0.024215762,-0.04780377,-0.119405456,0.048047576,0.045484066,1.4279508e-34,0.0778154,-0.07032939,0.030871175,-0.077386804,-0.07655724,0.095090166,0.03670491,0.013066646,0.056751624,-0.0006645797,0.05303063,0.013489484,-0.017746104,0.0016793001,-0.003573258,0.042660024,-0.06777031,0.003554347,-0.044262774,0.020602323,-0.04851769,0.060449548,-0.04531839,-0.060517613,0.06152449,0.035554234,-0.018344866,0.12168652,-0.02840862,-0.030420186,0.108481854,-0.0045988,0.013682968,-0.048063364,-0.069774665,0.08812652,-0.03438365,-0.0049199252,-0.023329223,-0.00044240407,-0.05136399,0.003480292,-0.025555406,0.054521732,0.023885954,0.048342187,-0.085009284,0.03938795,-0.03643135,-0.028672645,0.004124278,-0.021775996,0.09065494,0.008005356,-0.008785739,0.0957443,0.03348529,0.05117546,-0.06483976,-0.003127295,-0.004184873,-0.08322043,0.11665395,0.07666103,0.022315245,0.0140080005,-0.018467838,0.008842762,-0.003223858,-0.010541085,0.022375239,0.0027057254,-0.042516734,0.002966779,-0.05382427,-0.09023432,-0.10948875,-0.035995107,0.046536103,0.06263136,-0.07107655,0.008004547,-0.008434132,-0.011111123,-0.043672547,-0.09514481,0.008956947,0.106147505,0.022168143,0.104298085,-0.035483494,-0.0016768256,-0.03466647,-0.033735033,0.067319535,-2.5831124e-08,0.08542653,-0.01929264,-0.01359266,-0.021792503,0.038532306,0.011132611,-0.058415875,0.05714077,0.02206284,-0.0017790925,-0.010178985,0.080340855,-0.048065282,-0.001675583,0.070747524,0.015285095,-0.010330647,-0.01811317,-0.041365676,0.045288663,-0.073043406,-0.023053698,-0.12849712,-0.010645281,0.063466996,-0.06115019,0.05639673,0.054209683,-0.040427893,0.0164932,-0.026698494,0.021653099,0.003605495,-0.085222244,-0.08002988,0.035508953,-0.044249337,-0.06906885,0.042407002,0.04021889,0.078987576,-0.002468166,-0.034184042,0.021645082,0.0027152158,0.055025183,-0.015074819,0.022938306,-8.507582e-06,0.026177434,0.0013389833,-0.007163909,-0.049714074,-0.047170505,-0.13254347,0.049410265,-0.032775667,-0.06215822,-0.013120193,-0.031864483,0.060498208,0.041190848,0.18664815,-0.057582177 +2.7.2.18,"The enzyme is a dimeric complex consisting of an ATP-binding protein (FakA) and a fatty acid-binding protein (FakB). The first step in the reaction is the binding of FakB (with a bound fatty acid) to FakA. The fatty acid bound to FakB is then phosphorylated by FakA, and the fatty acyl phosphate-bound FakB is released from the complex. In the presence of an exchangeable fatty acid pool in the cell membrane, the fatty acy phosphate bound to FakB exchanges with a fatty acid to regenerate the substrate for FakA. The system is widespread in Gram-positive bacteria, with most strains possessing a single FakA protein along with multiple FakB subunits that differ in their specificity towards fatty acid substrates.",384,0.99999994,-0.12085177,-0.03369507,-0.070644476,-0.0023860217,0.0166016,0.035603106,-0.048488386,0.045962546,0.03299683,-0.056746263,0.016506523,-0.06740006,-0.011179939,0.012149956,0.0016616728,-0.062348824,-0.049165208,-0.00015826168,-0.059416916,-0.030279897,0.05149955,0.0065668933,-0.09392899,-0.08468358,0.0021772336,-0.003324708,0.064574935,-0.04533839,0.0060812584,-0.07359907,-0.00757555,-0.060506154,0.105213985,-0.01651428,0.0052363076,0.14792536,-0.029482884,-0.06565006,0.11739274,-0.04481027,0.07727744,-0.028330063,0.071687564,-0.0012072754,0.013311371,0.021827642,0.0261478,0.029372033,0.037726074,-0.06670978,-0.03994031,-0.056351822,-0.06992331,0.07554993,0.01731753,0.06509215,-0.012441929,-0.0017187075,-0.05597391,0.0025149612,0.004652249,-0.06605693,0.033887707,0.03849307,0.03185503,-0.08973426,-0.037515238,-0.027718196,0.03863968,0.01097304,-0.06571344,0.0017282525,0.01577192,0.026240628,0.020924686,0.029894687,-0.080978185,0.028857213,0.04554909,0.002324628,0.04665382,-0.038120203,0.03176676,0.0912451,-0.004889637,-0.109233394,0.046334554,0.0062266127,0.034590714,0.07648977,0.037135232,-0.0038244198,0.014984762,-0.028528286,-0.09237999,0.03855645,0.005373322,-0.033768546,-0.013389738,-0.014237537,0.025884826,0.026156811,0.08333677,-0.029909827,-0.06842512,-0.051026534,-0.07017059,0.09509713,-0.022673741,0.036065917,0.007880366,-0.00728651,0.07716265,-0.044596467,0.010025717,0.027781446,0.00966445,-0.0800059,-0.008611884,-0.020328663,-0.08316729,-0.045200486,0.04865764,0.03435247,0.0024577242,0.02373918,-0.10668272,1.4507195e-33,-0.010419644,-0.0097216135,-0.035169322,-0.04407061,0.023058107,-0.09668682,-0.049322512,-0.056026135,-0.050658405,0.027663225,0.048252195,-0.020200728,0.009966674,0.02050566,-0.049472958,0.010668657,-0.06926494,0.016786756,0.027284855,-0.013742372,0.04325673,0.03195046,0.047821365,-0.02329547,0.03388413,0.011797582,-0.029619485,-0.0043484345,-0.046866067,0.014868755,0.022591216,-0.048026804,-0.08644864,0.01913507,0.04164579,-0.032140423,-0.042438794,-0.055095,-0.01701867,-0.021643728,0.002520461,0.0005600759,-0.013290547,0.026427275,0.07284541,-0.007031103,-0.06423531,0.09426765,0.022156008,0.03417083,0.061795264,-0.082517125,0.09285996,-0.0007566303,-0.09823582,0.032438036,-0.049158186,0.01341379,0.021573313,-0.021088649,0.0565418,0.06807601,-0.07278556,0.10936739,-0.009623277,0.06132754,-0.077325635,-0.054412905,0.02509398,0.14992781,0.0046862685,-0.015926555,0.04691493,0.005073717,0.013386804,0.0033795768,-0.041963696,-0.007857385,-0.06594501,0.09802813,0.0136237405,-0.036643606,0.051337607,-0.05638748,-0.073184535,-0.05473453,-0.027948322,-0.058283173,0.026361134,-0.01876468,0.036257856,-0.024163771,-0.03293698,0.0826246,0.02337515,-3.056082e-33,0.15505604,-0.1243521,0.08399029,-0.069159314,-0.020035557,0.06671866,0.017359287,0.033569887,0.04801003,0.00087117404,-0.022515198,-0.009224545,0.010709998,-0.0017609897,0.030347517,0.0016554404,-0.02881759,0.06661559,-0.010908714,-0.031773683,0.004043209,0.01947189,0.023225313,0.098463826,0.014469764,0.013180212,-0.041840848,0.12785338,-0.06644821,0.04812793,0.0039697853,-0.03920786,-0.047828645,-0.010478285,-0.078949705,-0.047632564,-0.037510812,-0.024081433,0.029128985,0.032524712,0.1072296,-0.0014205066,-0.0045943665,-0.00086971524,0.022572897,-0.0043672994,-0.017070714,0.0073178536,0.029622683,-0.15422532,0.00632243,-0.011799302,0.0136513375,0.0019128708,-0.005122759,0.11720094,-0.0049167625,0.07172338,0.008266696,-0.03250915,-0.0812252,-0.19452319,0.04126722,0.034598142,0.04325066,0.050765507,0.035198268,-0.00700441,-0.011481196,0.0800433,0.045394927,0.09671822,-0.018034374,0.05523821,0.07725145,0.039405078,-0.082604036,-0.006195629,-0.020292789,-0.00982974,-0.030494636,0.022595508,-0.059546627,-0.031040046,0.025337901,0.010238747,0.017698871,0.084912896,-0.007726744,0.023351276,-0.023768438,0.02202621,-0.025222791,0.017251372,0.038842194,-4.3201297e-08,0.06495343,-0.022017011,0.02078209,0.009365877,-0.019908193,0.06771805,-0.028104244,-0.031464733,0.05040711,-0.027284501,-0.06559541,0.09433463,0.0008039606,0.03488966,-0.0033683951,0.01295751,-0.09811486,-0.013515793,-0.027781636,-0.07620852,-0.005845923,-0.045645457,0.0035921372,0.09364571,0.041311614,-0.02097297,-0.003879771,0.026899679,-0.061150018,-0.013897488,-0.00040982285,0.010197163,-0.04032045,-0.0013065935,-0.019816369,0.05521514,-0.014901485,-0.096302,-0.0364765,0.06534865,0.050089978,0.0020585323,-0.05418194,-0.0076149455,-0.01900154,0.065883934,0.011630164,0.019845316,-0.062421523,-0.014068043,0.050620995,0.037541173,-0.09281555,-0.024527498,-0.07087765,-0.026785929,-0.03323347,-0.04946422,-0.024031766,0.029203882,0.07355583,0.053446233,0.12939444,-0.0563898 +2.8.2.40,The enzyme catalyses the last step in the production of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex.,384,0.99999994,-0.080121174,-0.033768747,-0.014728595,-0.024352882,0.024101993,0.043279633,-0.04160469,0.099344835,-0.055366423,-0.023902157,-0.06012436,0.018219396,0.05954414,0.010127151,-0.0044089598,0.07839008,-0.101241656,0.007907716,-0.021652905,-0.043271337,-0.014323876,0.049958497,-0.0010196859,-0.04943207,0.08743916,0.07180831,0.046068028,-0.00018808902,-0.039155696,-0.026996259,0.013962793,-0.047330007,0.0010989286,-0.0309025,0.013328353,0.026702594,-0.06221393,-0.09755957,0.06946949,0.032730114,0.0685239,0.037390653,-0.05531622,0.03143858,0.022653699,-0.016382858,-0.046097472,0.12167138,0.06287456,0.012954597,-0.08430099,-0.04292215,-0.05161387,0.083140045,0.04534535,0.024520343,-0.01755494,0.018159064,0.025953876,0.0023163715,0.037299402,0.005077518,0.02574587,-0.005416028,0.03682243,0.021582855,-0.021516688,0.0034949332,0.01575299,0.00018377333,-0.034884386,-0.024338428,-0.09678813,0.03659733,-0.026454004,0.018353894,-0.03540489,-0.018487012,-0.010182972,0.08372666,-0.038992465,-0.02282919,0.012688128,0.028464904,0.050966606,-0.012192967,0.099290036,0.009341046,0.07486154,0.062259156,-0.017543554,-0.036301553,-0.0013389486,-0.041470688,-0.061452545,0.017890733,0.058196016,0.07494612,0.017166277,-0.018090028,0.036795527,-0.016773945,-0.010239831,-0.097756304,-0.03302503,0.035640046,0.0007805562,0.084468536,-0.017576668,-0.0068556387,-0.012253834,-0.018154528,0.028846003,-0.04146918,-0.01161338,0.100338176,0.08853509,0.0002782078,-0.1434658,-0.0038198943,0.0029643099,-0.041431803,0.033427786,-0.022142315,-0.11245462,0.033756305,-0.08790948,-1.11840445e-33,0.04494511,-0.036609072,0.023335567,-0.026676008,0.056381065,-0.016077759,-0.13087782,0.06808842,-0.052562047,-0.015137596,-0.08843595,-0.060103886,-0.008502649,-0.013583293,-0.060344163,0.0109335445,0.05421834,0.023086686,0.054509748,0.07273806,0.022486815,-0.017373448,-0.01224657,0.005725623,-0.0034235984,0.092146456,0.006470774,0.056533046,0.004182782,-0.007827203,0.0033535399,-0.09002681,-0.07213063,-0.05048804,0.009864872,-0.052044462,-0.055658326,-0.056610573,0.06980039,0.0077106035,0.005482884,-0.05226538,-0.011173081,-0.03427968,0.04326942,0.028068855,0.024180708,0.004556362,0.012368199,0.00079768966,0.02558128,-0.019460471,0.060595497,0.01627672,0.026817858,-0.033617195,-0.0028296066,0.021645723,0.032012332,0.0641241,0.03042491,0.039652307,-0.034959067,0.08604826,-0.053307146,-0.035661373,-0.022276126,0.07256326,0.061960537,-0.018318733,-0.0031526745,-0.04279974,-0.020978928,-0.071382545,0.113787696,0.019987315,-0.027666185,-0.0028668928,0.01797791,-0.027777782,0.004295414,0.019494565,-0.06657402,-0.014852917,-0.015554134,0.015256071,-0.029445997,-0.0046156333,-0.045722544,-0.015680308,0.010335736,-0.016251856,-0.07832666,0.038804874,0.009873075,-3.4433781e-34,0.106314994,-0.14224759,0.047211356,-0.1390956,-0.050287373,-0.021121208,0.029428938,-0.063150235,0.04499119,0.027902149,-0.00821301,-0.038327496,-0.032505974,-0.047171712,-0.063312225,0.0031894674,0.0570845,0.09483649,-0.042095505,-0.027686395,0.051721927,0.09459588,0.034807447,-0.013505451,-0.046963513,0.009892654,0.049435977,0.041291665,0.1274594,0.124040656,-0.03606506,0.03198108,0.028203938,-0.05983071,-0.07629319,0.029307071,-0.026269909,-0.0145029845,0.092031784,-0.02894857,0.050000936,0.00035017583,-0.070952095,0.015115996,0.047501136,0.025063716,-0.019250117,0.018749006,-0.02430231,-0.034543205,0.11279202,-0.028138442,0.025988108,-0.005666356,-0.0136082275,0.014402687,-0.035916,-0.05123796,0.028722834,-0.036357105,-0.029945198,-0.038318053,-0.0025515992,-0.028086206,-0.028713955,0.10960248,-0.004003549,0.05078542,0.06283238,-0.072943345,-0.002319713,-0.01140121,-0.011313261,0.08979967,0.01083866,0.003481158,-0.063458785,0.03683936,0.01660556,0.0451649,-0.07835921,0.010345915,-0.017441101,-0.11063677,-0.0031352118,-0.08096597,-0.0057139294,0.08162291,-0.014584356,0.06716514,-0.039343998,0.059222694,-0.09648246,0.099575736,0.0433439,-2.4890639e-08,0.030862601,-0.06297854,0.10427546,0.012222051,0.02790823,0.016056573,0.026712783,0.02682355,0.09318,0.041163526,0.044323307,0.059812874,-0.0016925669,-0.008657854,0.052209467,0.023126673,-0.0029943255,-0.06324844,-0.0004041173,-0.04951347,0.00033812234,-0.018988116,0.039246447,0.034525968,-0.016230192,-0.09748489,0.0023808002,0.019550266,-0.05251017,0.0033323278,0.034835484,0.058262724,-0.06938622,-0.10510802,-0.08132564,-0.04820472,-0.0016964512,-0.040985763,0.098697044,-0.010409236,-0.03869894,-0.030198056,-0.06043027,0.042888377,-0.04691452,0.03129543,-0.026944676,0.0689682,-0.008179439,-0.039210327,0.083830275,-0.008445258,-0.019683901,-0.08715627,-0.09043776,0.078309625,0.00609353,-0.035310447,-0.09074275,-0.048563883,-0.0015308227,-0.027947254,0.17463031,-0.09173508 +3.1.1.118,"The human enzyme shows broad specificity, and has a preference for phosphatidate over other phospholipids. Unlike EC 3.1.1.32, phospholipase A1, it is also active against phosphatidylinositol. It is not active towards acyl groups linked at the sn-2 position.",384,1.0,-0.031907693,-0.0806428,-0.0764451,-0.03614888,0.05915125,0.022866406,-0.039758578,0.037298985,0.048570946,-0.008989549,0.042562712,-0.02533359,-0.10142437,0.05840686,0.033061467,0.0046791546,-0.02837252,-0.025251534,-0.0026981262,-0.04119902,0.0149060525,-0.007820169,0.010154139,0.06340481,-0.027823819,-0.037361685,-0.009997424,0.0075821104,-0.00325371,-0.064086445,-0.024833245,-0.05142432,0.07959524,-0.036831956,-0.02394763,0.008810643,-0.029067503,-0.01597119,0.007737641,0.04196643,0.07838697,-0.06252404,-0.0015832578,-0.033039466,-0.0016130926,-0.0017561179,-0.043460317,0.014750048,-0.0028903007,0.023685645,-0.0073091676,-0.09183808,-0.036937773,0.010965467,-0.10460746,0.06843792,-0.11489076,0.02601434,-0.010405639,-0.017545994,-0.04734792,-0.032868676,0.06309134,0.091809556,0.03263832,-0.03240173,0.012798342,-0.14861497,0.041299555,0.012962013,-0.03305696,-0.11062456,0.005031521,0.05701626,0.0550514,0.07022489,0.03623001,-0.03939413,0.01078642,-0.08525569,0.058909353,-0.04987478,-0.020803947,0.050320257,0.04719245,-0.010436869,-0.06658673,-0.002222974,-0.04044609,0.061370414,0.04863765,-0.034427464,0.0830815,0.008546745,-0.004681224,0.06899801,-0.0077124047,0.10547835,-0.03458159,-0.0019091674,0.00067258184,0.07532524,-0.09131818,-0.0052108415,0.023501182,0.039616212,0.021697111,-0.067728266,-0.02838748,-0.0060064257,0.025400197,-0.06541043,0.034644824,-0.045464005,0.031171598,0.023002341,-0.032435793,-0.07214737,0.058318097,-0.012858333,-0.005591163,-0.10067363,-0.003325244,0.006240302,-0.009984727,0.06852801,-0.09935681,3.715131e-33,0.0029694831,0.018486334,0.00095361704,-0.017343547,-0.006030213,0.006137886,-0.042109106,0.02444308,-0.024379961,-0.03488419,-0.032212395,-0.018960478,0.035170663,0.08843267,-0.030109681,0.006997984,0.027463475,0.039686512,0.0021225994,0.02520254,0.072389215,-0.058943577,-0.04545563,0.008560859,0.041746352,-0.00032841385,-0.1101139,0.042198204,0.014838311,0.019367695,-0.0357271,-0.06535929,-0.08686471,0.052659795,-0.021041522,0.013392587,-0.054787636,-0.03977917,-0.031107089,0.051599383,-0.023301052,0.050348047,-0.021080008,-0.05921435,0.06389368,-0.032874912,-0.11818585,0.109119296,0.00844549,0.03244331,0.01938204,-0.023652427,0.085176565,0.0041154847,0.048989054,0.0014173283,-0.051295966,0.03981052,-0.02221202,-0.0062670144,0.05034478,0.07694972,-0.060847737,0.010187057,0.013839979,0.081546076,-0.037130244,-0.06930283,-0.07308494,0.07959867,0.050484598,0.032807957,-0.0040488117,0.07873977,0.025672821,-0.07093375,0.057349868,0.071000315,0.0047651506,0.040964555,0.033297088,-0.007919886,0.027394501,0.040548056,-0.08127828,-0.019574875,0.024268547,-0.006915152,0.027867965,0.0018238262,0.044991944,-0.06526177,-0.028021604,0.11802656,-0.043124914,-4.6005932e-33,0.017164672,-0.032391537,0.014953357,-0.09848221,-0.078117125,0.116688356,0.07924052,0.0060916306,0.11887325,0.03401901,0.102595866,-0.011723556,0.043092035,-0.08997242,0.057370886,0.003928328,-0.06529617,-0.02058751,0.072831936,-0.004770364,-0.0717262,0.07520405,-0.04452066,0.116911456,0.06450026,-0.056713026,-0.084566146,0.048732676,-0.03707805,0.013632011,-0.117940105,0.021673592,-0.05066855,-0.07297587,-0.035708733,0.023950687,-0.0835752,0.011597903,0.033338938,0.019549232,0.035970364,0.059718423,0.07767346,0.010628701,0.05545864,0.12451636,-0.038074855,0.05803544,-0.043149587,-0.029002309,-0.065626904,0.011830216,0.025663074,0.07352862,0.03125873,0.09797832,0.014054299,0.038469248,-0.02829147,-0.09061419,-0.04261496,-0.06680264,0.0070251753,0.050871596,0.0046855537,0.025487717,-0.08434873,-0.007716115,-0.0039597326,0.0006198331,0.07577179,-0.018999226,-0.06293167,0.0025851529,-0.027840752,-0.026469138,-0.04092195,-0.03951033,0.028956452,-0.044625647,-0.0048508164,0.040039454,0.02035765,-0.04339974,0.022216078,0.077447,-0.020937527,0.047970507,-0.0059915395,0.026719535,0.008560791,-0.057702094,-0.114153326,-0.00064369396,-0.023756225,-4.0837495e-08,0.117490314,0.011387591,0.08126619,-0.061312586,0.0024412468,-0.013941904,0.018117879,-6.349887e-05,0.002557405,0.015209106,-0.06504023,0.042086747,0.064792484,-0.007599472,0.09365928,0.04542519,-0.03849324,0.046998724,-0.027855333,-0.00815764,0.0019215496,0.009219151,-0.05204768,-0.0020982886,0.022909326,0.009518778,0.04555943,0.02453445,-0.06096434,-0.03933255,-0.0025419537,-0.014087989,0.016370399,-0.021658126,0.010110683,-0.0027904105,-0.012481528,-0.052624103,-0.10142244,0.06806742,0.0052935104,-0.07989869,-0.013538822,-0.016099382,0.019045295,0.019560928,0.07180936,-0.029934354,-0.032827217,-0.039865963,-0.0023210347,-0.07364425,-0.015639305,-0.0676882,-0.058504038,-0.081230104,-0.012168842,-0.06376784,0.023107637,-0.06494264,0.06930625,0.07879816,0.15768257,-0.024737218 +3.1.6.21,"Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III sulfatase family. It is active against linear primary-alkyl sulfate esters, such as dodecyl sulfate, decyl sulfate, octyl sulfate, and hexyl sulfate. The enzyme from Pseudomonas aeruginosa is secreted out of the cell. The catalytic mechanism begins with activation of a water molecule by the binuclear Zn2+ cluster, resulting in a nucleophilic attack on the carbon atom. cf. EC 3.1.6.22, branched primary-alkylsulfatase, and EC 3.1.6.19, (R)-specific secondary-alkylsulfatase (type III).",384,1.0,-0.106223226,-0.086912,-0.06162756,0.005707257,0.059056252,0.035721797,-0.070728585,0.044849686,0.029993437,-0.04444556,2.2326801e-06,-0.00041676764,-0.05338206,0.10125766,-0.05534492,0.027665406,-0.09594348,-0.017094063,-0.016204013,-0.022399794,0.09964773,0.051686395,-0.07049962,-0.022815935,0.0199456,0.07959917,0.07499844,0.014008503,-0.05733854,0.029432137,-0.044383857,-0.13482586,0.09056633,-0.07358049,0.044459116,0.0073526353,-0.021069674,-0.015035599,0.069270305,-0.033206746,0.06786046,0.040103905,0.0037464642,-0.11039544,0.013672838,-0.08528744,-0.010161863,0.02906155,0.026689027,-0.06229391,-0.028879669,-0.050924707,-0.0060103503,0.09849028,-0.031066613,-0.036844652,-0.047681607,-0.02401162,-0.0023788852,-0.046041258,-0.028727924,-0.010639202,0.0052194926,-0.03670548,0.022617714,-0.008896861,0.0076556862,-0.035108972,0.06028285,-0.0059664855,-0.103426084,-0.008187928,-0.0077929827,0.052112956,0.017137686,-0.000110946894,0.04357746,-0.05010372,0.023441829,-0.05371892,0.020268152,-0.03119065,0.06414144,0.12119707,0.023270408,-0.044133622,0.0034767129,0.017807404,0.057814788,0.034365814,-0.012377585,-0.058300063,-0.029840417,-0.02577599,-0.031458605,0.03212361,-0.012121102,0.12553337,0.00094618957,-0.015689619,0.020120304,0.010994777,-0.021008367,-0.121011466,0.058163263,0.014895013,0.056256313,0.094572745,0.031292856,0.0034894317,0.008537401,-0.03732972,0.008796574,-0.0023775348,-0.04492755,0.12563449,0.026233835,-0.03876866,-0.13198166,0.05658319,0.034778956,-0.031179596,0.058960512,-0.0172929,0.028922644,0.034523223,-0.17030668,1.406749e-33,0.014272514,0.04562701,0.018317945,-0.018990438,-0.0070381844,-0.04499649,-0.05970273,0.035013422,-0.0024050823,0.04241907,-0.019090705,-0.035024818,0.013295494,-0.019828271,-0.040285703,-0.013886678,-0.0055313366,-0.0008181328,-0.009813331,-0.025477063,0.07960853,0.02947467,-0.009868017,-0.07565593,0.06012349,0.0029375344,0.04198598,0.0077043194,0.029790599,0.021946598,0.051136546,-0.08944802,-0.084224746,-0.05364269,0.12313672,0.0037468558,-0.018577475,-0.029570075,0.05544572,0.0029221994,0.031030787,0.011032716,-0.03753144,-0.026440114,0.04116539,-0.04425214,-0.053283524,0.10711243,0.028188627,0.04288906,0.056449864,-0.086940296,0.046673518,0.044524394,-0.017048815,-0.041151356,0.00014698032,-0.004320041,0.07323902,0.026038576,0.06101998,0.020025013,-0.053599905,-0.008854002,-0.05482289,0.0064837085,-0.023803197,-0.03255348,0.0015720351,0.0885084,-0.06350704,-0.01859983,-0.0023191946,0.08270522,-0.031352106,-0.033852898,-0.0051451433,0.019960595,0.05336783,0.029049024,-0.059145305,-0.06604535,0.010151296,0.032008745,-0.1533185,-0.017930409,-0.014923065,0.0034244456,-0.038650107,-0.04566759,0.022546439,-0.03520699,-0.033410825,0.035034306,0.016153047,-3.4523465e-33,0.06971479,-0.050360702,0.035176545,-0.14827374,-0.048398767,0.018783092,0.029414956,0.0334211,0.06358009,-0.03314276,0.041391283,0.047083147,0.043510444,-0.009455608,0.057676353,0.07499707,0.0010376463,-0.029354082,0.006782541,-0.067878485,0.045763187,0.052541316,0.02007955,0.107378766,0.001951241,0.031332504,-0.015208797,0.07172716,0.058002025,0.14481169,-0.045289148,0.05258973,0.010587353,-0.07016418,-0.06879661,0.031900473,-0.008351026,-0.045270197,0.024948148,0.013904886,0.052135367,-0.040997252,0.0003123128,0.11616108,-0.01737179,0.06593247,0.0060789073,0.038694657,0.038865592,-0.09795587,0.010497911,-0.021940451,0.020682024,0.05098599,0.013380427,0.0564967,0.017396986,-0.034283165,-0.10115721,-0.019800676,-0.032275952,-0.05520706,0.009974749,-0.05572121,-0.031047963,-0.0037342932,0.017133899,-0.067143485,0.010837841,-0.034405228,0.010411666,-0.012880327,-0.043184385,-0.045808394,-0.072192274,-0.022928711,-0.054622322,0.023719385,-0.010963437,0.0025239561,0.025339918,0.062411696,0.0051733255,-0.04430313,0.036608957,-0.04214898,0.0054136687,0.1221483,-0.07031725,0.009564058,-0.01595621,-0.04471484,0.0037800288,0.06566128,-0.06980221,-4.627544e-08,-0.020660976,-0.039220132,0.09898588,0.002640284,-0.053252157,0.077591226,-0.0487749,0.001610799,0.022921408,0.015595268,-0.0076103653,0.06658729,-0.027300553,0.026162146,0.06563979,0.019956376,-0.066427335,-0.0005764559,-0.035708852,-0.09059366,-0.0147113465,-0.06547787,-0.09493257,0.02688166,0.046068437,-0.03448529,0.017447278,-0.017191822,-0.08763815,0.020535022,-0.013339136,0.045808,-0.0059463815,0.027400026,-0.060485464,0.04152068,-0.0027585516,-0.05052098,-0.057988033,-0.014155612,0.04631054,0.051409665,-0.092302494,0.00694491,0.039211664,0.0343077,0.04269628,0.04534224,-0.00960329,-0.030645302,0.06561625,-0.02420314,0.00021985617,-0.016417503,-0.05612616,0.059644055,-0.030479575,-0.09450702,0.03030712,0.036650714,0.082642324,-0.058612175,0.13758677,0.004587328 +3.1.6.22,"Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III family. The enzyme, characterized from a Pseudomonas strain, is specific for branched primary-alkyl sulfate esters and does not act on linear substrates such as dodecyl sulfate. cf. EC 3.1.6.1, arylsulfatase (type I), EC 1.14.11.77, alkyl sulfatase, EC 3.1.6.19, (R)-specific secondary-alkylsulfatase (type III) and EC 3.1.6.21, linear primary-alkylsulfatase.",384,0.99999994,-0.06907001,-0.11798858,-0.06682949,-0.030086454,0.043908525,0.017197601,-0.08239843,0.03011633,0.018080818,-0.100200325,0.004118223,-0.0075562587,-0.060693167,0.068049766,-0.047106482,-0.0049105277,-0.06525455,-0.029850196,0.0120970225,0.018450169,0.09934386,0.05896752,-0.06671593,-0.0008989597,0.04544916,0.048735864,0.052069675,0.02696801,-0.043565292,0.012448808,-0.047592185,-0.09753472,0.06256494,-0.048910122,0.07598608,0.019789696,-0.05492812,-0.017620143,0.056198724,-0.021765111,0.10248433,0.065440044,0.02128858,-0.107662156,0.008656917,-0.07588963,-0.012597859,0.00061889365,0.0035123837,-0.05181869,-0.021268658,-0.053387325,-0.006434172,0.09556693,-0.009453837,-0.051007796,-0.045609694,0.025712036,-0.00423911,0.0030938494,-0.02263495,-0.0008230186,0.030981652,-0.08304053,-0.0063532144,0.0025701665,0.014474183,-0.06821198,0.01999599,-0.015823094,-0.17015974,-0.022395603,-0.025244035,0.071084015,-0.0018084273,0.037266072,0.043502215,-0.06831764,0.017082775,-0.08011253,0.0056444635,-0.023125798,0.034789808,0.11126809,0.010086317,-0.042882692,-0.019632773,0.033320457,0.048549976,0.06558569,0.01221909,-0.0289442,-0.007325336,-0.02045252,-0.038322985,0.049338702,-0.024347836,0.15095434,0.0135733355,-0.0006763394,0.045048174,0.007198905,0.0032880954,-0.110069394,0.005158304,0.038659684,0.026765939,0.09371724,0.010720747,-0.0073965653,0.008617004,-0.007927008,0.040463362,-0.038035907,-0.052115485,0.10136044,0.029015522,-0.077557884,-0.110371865,0.015934315,0.05326819,-0.042240646,0.11059332,-0.030807799,0.038878165,0.026050333,-0.15818235,1.5175446e-33,0.003747146,0.062382814,0.042624485,-0.036360774,-0.034344107,-0.04405126,-0.066224426,0.03589383,0.00040883702,0.022599414,0.0014532654,0.0003209565,0.009539739,-0.057039563,-0.018868549,0.013178089,0.013169542,0.036154386,0.004904939,0.0061438256,0.05315568,0.042833984,-0.039133206,-0.059556026,0.07039221,0.0013305189,0.04013262,-0.01935206,0.0023902445,0.015733758,0.056933805,-0.10193904,-0.10465588,-0.048949942,0.08763638,-0.03256887,-0.008329442,-0.028464606,0.022471767,-0.027923055,0.031883337,0.020642474,-0.013300087,0.033327572,0.048025638,-0.036229055,-0.051086623,0.12580796,-0.012887982,0.0666165,0.010092683,-0.063074216,0.08259646,0.007824056,-0.021156684,-0.009450578,-0.0149521455,0.03485127,0.10919894,0.045297276,0.03526865,0.02381354,-0.066236876,0.0053316294,-0.048913673,0.0028110528,-0.041947335,-0.024260575,0.0010433394,0.1088384,-0.028938552,-0.0044429745,-0.008807461,0.098832525,-0.0024711022,-0.06527788,-0.013361432,0.008083276,0.06174117,0.015203828,-0.104755595,-0.03909638,0.011077002,0.005176623,-0.17540252,-0.014991602,-0.017393809,0.01652999,-0.030348243,-0.049407057,0.0022799636,0.009612011,-0.032727297,0.05988166,-0.0035823982,-2.5929067e-33,0.08916865,-0.017599884,0.016272474,-0.17240287,-0.05956415,0.027328482,0.037169695,0.01332476,0.05054673,-0.051286906,0.06446888,0.037976407,0.049302213,-0.02770192,0.05103232,0.06507908,-0.04931056,-0.011690564,0.014622293,-0.03890121,0.056226436,0.071811765,0.014335956,0.123043396,-0.0074526384,0.032333817,-0.024974698,0.069578305,0.045117486,0.11366882,-0.018465504,0.029441757,0.0241876,-0.088193044,-0.08026736,-0.0023463934,0.0022388508,-0.04622424,-0.0034602017,0.04476064,0.04136155,-0.0037234914,0.00737438,0.08860167,-0.0026739049,0.066607505,-0.030393321,0.052333917,0.06316968,-0.08508583,-0.02142742,-0.009343443,0.0033755424,0.037863366,0.015525412,0.059730332,0.0054662568,-0.012055714,-0.08931097,-0.0073715583,-0.061003767,-0.06143115,0.024807421,-0.04328004,-0.019335713,-0.011860165,0.01056602,-0.06618284,0.021097079,-0.00769625,0.028613128,0.017777955,-0.05380393,-0.044818554,-0.044356678,-0.038402855,-0.011829794,0.05143631,0.008923499,-0.008151612,0.061632928,0.057657253,0.021969205,-0.0035667417,0.0053506377,-0.036618568,0.0017810507,0.10957742,-0.060007047,0.0052261953,-0.027722389,-0.040233318,-0.030529222,0.06977624,-0.07131346,-4.4597243e-08,-0.007834013,-0.038500756,0.05382732,-0.017372256,-0.048729096,0.062472302,-0.0587334,-0.019636914,0.040021818,0.046136085,-0.0028743614,0.06061992,0.002164189,0.020176915,0.06229091,-0.01348797,-0.053492036,0.018949306,-0.035402358,-0.014821588,0.013344119,-0.03694046,-0.07131252,-0.0009544553,0.0409899,-0.04783776,-0.009884691,-0.015736105,-0.09934497,0.06438048,-0.01514849,0.06897675,0.0007071824,-0.0071456456,-0.013375463,0.045000818,-0.015952764,-0.042068124,-0.0550951,0.02831232,0.022297703,-0.023403956,-0.08086059,-0.006320243,0.053574704,0.012020387,0.031451024,0.03841224,0.023378134,-0.034776576,0.05468002,-0.033296287,0.0075337016,-0.028762998,-0.040348936,0.053168792,-0.0085585965,-0.07527915,0.018729046,-0.0028477747,0.12564364,-0.03662079,0.12816864,0.005006643 +3.1.21.10,The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions.,384,1.0,0.027176572,-0.04556416,-0.08512642,-0.03280609,0.042065814,-0.049423013,-0.042016424,0.004466651,-0.018593052,0.006786315,0.06121777,0.021185307,-0.13500316,0.07141796,-0.00035522704,0.017325066,-0.15014713,0.027816808,0.009652047,-0.060884625,0.037099604,0.019029977,0.07687008,0.003517053,0.02003199,-0.02557363,0.008767613,-0.037563395,-0.026410012,-0.09312233,-0.011557181,-0.047762077,-0.048876792,-0.011111567,0.09474889,0.054716066,0.08330917,0.028517885,0.024763782,-0.06138147,0.07922499,-0.026887573,-0.053156767,0.083079726,-0.04078592,0.0122793,-0.023086706,-0.061088286,-0.035592433,-0.016519142,0.012003067,-0.04277523,0.042292908,-0.012393381,-0.008183182,0.0939142,-0.046837796,-0.0035709357,0.0110325,0.062330134,-0.008801031,-0.04820668,-0.00863162,-0.03564391,0.02963375,-0.044177253,0.10519467,-0.013162825,-0.056007408,0.003600499,0.018721806,-0.033453494,-0.051868536,0.047512773,0.058069978,0.047422495,0.0091412105,-0.0048242947,0.038876712,0.037090607,-0.0664481,-0.08116068,0.052380025,0.034122754,0.02393732,-0.019508637,0.03603133,0.0778026,-0.005379352,0.044630434,-0.046520513,-0.046319522,-0.018159468,-0.07685605,0.005987998,-0.0003042153,-0.031946898,0.089454904,-0.028028168,-0.04846744,-0.008197237,0.019195743,0.008446413,-0.026333375,0.06463219,0.043445617,0.041432925,0.05714572,-0.0029521177,-0.018851755,0.009169939,0.009317191,0.13701756,-0.043216877,-0.038487095,-0.03492148,-0.00023436206,0.008324722,-0.04370561,0.06544925,-0.011217024,0.05084173,0.06730951,0.05597281,-0.10342856,-0.007317594,0.044156484,3.0417274e-33,0.010301677,-0.0007161689,0.021028813,-0.050254162,-0.00197925,0.025540192,-0.062973656,0.037020862,-0.052247424,-0.014476816,-0.056201003,-0.0775267,0.03623403,0.077295244,0.037300333,0.053543195,0.07836185,-0.0396366,0.0014483976,-0.005529654,0.0550325,-0.017848114,-0.045120772,0.008210313,0.048273697,-0.030827982,-0.026178034,0.053930834,0.04946599,-0.022105552,-0.032749686,-0.07494492,0.03580919,0.104905605,0.052506782,0.07778058,-0.011592207,0.011823459,0.0075531756,0.0069127083,-0.0291515,0.004120483,0.00596727,-0.08360844,-0.0010025061,-0.0693271,0.053328108,0.027712712,-0.008613482,0.03799709,0.015281219,-0.015960652,-0.0492086,-0.024256293,0.005403222,0.036221817,0.024114348,0.05320409,0.03118489,0.004264382,-0.06757785,0.08601734,-0.056628536,-0.027419679,-0.011331923,0.047098666,-0.015406153,-0.051916428,-0.038822163,0.02776698,-0.03068394,-0.037795093,-0.014171454,-0.022418736,0.01864311,-0.0075727515,-0.05592841,-0.04421733,0.048782386,0.020006927,0.03615056,-0.12784491,-0.027028762,-0.014903432,-0.041097738,0.008283272,-0.059687298,-0.0032080656,-0.036769617,-0.028683897,0.018133817,-0.041920144,0.0250468,0.018725041,0.069318786,-4.7218234e-33,0.08701374,-0.00412807,0.11427433,-0.053684372,-0.072730616,0.12708311,0.0033519263,-0.018808942,-0.005534541,-0.029980406,0.12835811,-0.019912358,-0.051823515,-0.035804372,0.0070022363,0.014641186,-0.011928753,0.0793632,0.033364203,0.017832503,-0.069662385,0.14138365,-0.09816629,0.015615713,0.0764061,0.018398404,-0.062012658,0.094004445,-0.0100977495,-0.021357244,-0.076708555,-0.008897717,0.048022486,-0.058014046,-0.029926972,0.0420296,-0.0032832401,-0.027579289,-0.014001484,-0.0134727815,0.0021009096,0.05783673,-0.046904564,0.061885487,-0.0055420613,0.0801565,-0.11434654,0.030893035,-0.012570222,-0.019849343,0.014530472,0.07878115,-0.078028224,-0.06263086,0.05616947,-0.004109795,-0.009715135,-0.016609013,-0.030018011,-0.05435023,0.0140211955,-0.07601304,0.02466637,-0.018772509,0.06313666,-0.02251442,-0.059317343,0.08990661,0.011993535,-0.05829099,0.07032601,0.064498775,0.010533153,-0.034732386,-0.052193888,0.07594273,-0.13514918,-0.08019795,0.036699925,-0.055459756,-0.006582801,0.014673777,-0.039758954,0.0074997437,0.09828627,-0.040182717,-0.013557266,-0.0077851075,-0.05139942,0.041399732,-0.01883917,0.036540516,0.0031229022,0.104076765,0.03118306,-3.147664e-08,0.11312621,0.037590317,0.0015231882,-0.09338126,-0.0149560645,-0.034387812,0.040390573,0.032641392,0.037020925,0.11184129,-0.031699385,0.043065973,-0.0896778,0.039437804,0.055887423,-0.025680726,-0.050427157,0.010729815,-0.013628466,-0.019712683,-0.043458987,0.024472527,-0.13665454,0.06647191,-0.049456496,-0.02921659,0.09056833,0.073849835,-0.010949858,-0.10141146,0.030319495,-0.015055982,-0.01765408,0.031428576,-0.05975752,0.027644642,-0.037397914,0.012391633,-0.096912876,0.05420644,0.0086509185,-0.0142724095,-0.013823696,0.034979776,-0.07512593,-0.004307802,0.088195965,0.0029469177,-0.05484829,0.001837562,0.0671329,0.038725775,-0.014716429,-0.060940802,-0.09565339,0.03568542,0.016524205,0.034587324,-0.054094743,-0.040241532,0.016484685,-0.043775477,0.11265858,-0.08953916 +3.4.14.14,"Requires Fe2+ ad Zn2+. The enzyme participates in the biosynthesis of the enzyme cofactor mycofactocin. It catalyses cleavage of the mycofactocin precursor peptide following its modification by MftC to liberate its final two residues, which consist of a cross-linked valine-tyramine dipeptide.",384,1.0,-0.05575966,-0.087977596,-0.15094323,0.060566526,0.14329225,-0.034643557,0.043719333,0.057329252,-0.009922889,-0.016949212,0.0017678663,-0.018885838,-0.05775047,0.08325008,-0.07143618,0.056409493,0.004191305,0.053802483,0.06215281,0.018671118,0.023388777,0.057898346,0.03937191,-0.043584988,-0.05839454,-0.010563551,-0.0031196699,0.02256799,0.0549396,-0.033107057,-0.018000731,-0.013819164,-0.012183752,-0.046625447,0.061452225,0.040458668,0.021345582,-0.07568679,0.004317819,-0.027571078,0.05313781,0.021905122,0.00042357828,-0.034925804,0.012503741,-0.0321842,0.048442096,-0.014279884,0.030674854,0.08937106,-0.046475627,0.0064883204,-0.043063316,0.052141577,-0.051548727,0.02384869,-0.054518938,-0.061200917,0.0064713666,0.01853576,-0.035911385,0.025390022,-0.020864014,0.045937676,0.060355365,-0.045298066,-0.043920014,-0.046272133,0.01856895,-0.04112521,-0.012851035,-0.010496211,-0.037151627,0.0017099261,-0.0013504442,0.042744916,0.005862492,-0.052570693,0.05796456,0.017501356,-0.007048365,0.027371995,0.045841552,0.0367794,0.0763901,0.027912835,0.06927904,-0.018659247,-0.03233146,0.07713436,0.06847569,-0.026851902,0.0069295573,-0.033531733,0.04443248,-0.025579661,0.069666244,0.03455715,-0.022555284,0.015059637,-0.02798106,0.055312354,-0.025069991,-0.012978447,-0.018802576,0.015072602,-0.043372195,0.12777205,0.06156377,0.07932921,0.002032275,-0.0096405465,0.06379328,-0.033044517,0.006381262,0.1207455,0.043311752,-0.049417436,-0.036300942,0.006951981,0.05273657,-0.04456062,-0.030645458,0.083384775,-0.07421716,0.012935471,-0.11808451,4.6886366e-33,0.04570717,0.047142234,0.030663105,0.053111184,-0.05178305,-0.012481883,-0.11489392,-0.055262774,0.011451373,-0.002941181,-0.05667663,-0.027104033,0.073330805,0.05542248,-0.14250614,-0.12793927,0.0072961096,-0.038374357,0.070322886,0.03087302,-0.007383315,0.040579744,0.017429687,-0.030312544,0.010199727,0.0811551,-0.06489644,0.03537686,0.0013891979,0.021842483,-0.0146445315,-0.050866034,-0.086231366,-0.004652042,0.10573223,-0.026610116,0.036387704,-0.13517107,0.037399303,-0.036143035,-0.0018195967,-0.029628983,0.007911345,-0.077164516,0.050193783,-0.124028645,0.0446578,0.09365846,-0.04017365,0.010395406,0.06002024,-0.04147469,-0.039983306,0.0043624802,-0.07718758,-0.02752978,-0.054614894,-0.070852704,0.050156232,0.085643016,-0.023881555,-0.02452774,-0.041993342,0.17415449,0.004633682,-0.06919949,-0.045163892,-0.0034858633,0.023792347,0.07976715,-0.037369642,0.016857026,0.039125483,0.022079628,0.042842347,-0.04505901,-0.01972075,-0.028998466,0.024090828,-0.0403324,0.016490327,0.011520911,-0.022135288,0.043161303,-0.0035921508,-0.015488428,-0.04354425,-0.0463378,-0.044823095,-0.05171394,-0.0466468,-0.04677672,0.0243586,0.033973753,-0.010413357,-6.1272584e-33,0.0679065,-0.11719964,0.041559942,-0.13380623,-0.10117659,-0.026223833,0.06077869,-0.05769039,0.04614093,-0.017048841,0.056762937,-0.04660845,0.021173252,-0.08307784,-0.036007617,-0.008756026,-0.06798248,0.019475617,0.053682595,-0.037044864,-0.009958748,0.03209976,0.045373235,-0.026525069,0.015978653,0.010742702,-0.03403041,0.020136226,0.061859474,0.08753531,-0.06549787,-0.028523063,-0.042062886,-0.07191009,-0.03425092,0.034961138,-0.081143975,-0.019015554,0.052015636,-0.043601215,0.029512994,0.023400268,-0.017656002,0.0021570171,0.0020496363,-0.0032126256,-0.051392872,0.03853593,0.05532383,-0.05099247,-0.024928693,-0.048643306,-0.03134583,-0.007604351,0.0062830024,0.045889102,0.12648797,0.004115888,-0.01077477,0.034055747,0.012486695,0.09476384,0.046061832,-0.018966887,0.06992158,0.020373628,0.03111908,0.10819765,0.04233239,0.009177366,0.093878835,0.040050708,0.021076458,0.03362536,-0.008948751,-0.07916536,-0.029981507,0.051313113,0.07464976,-0.015544691,0.0037574798,0.018235913,-0.018620616,-0.07465387,-0.01820177,-0.023595769,0.02492272,0.08525039,0.025676029,-0.022597786,0.0040765563,0.0058378107,-0.008473327,0.0006638401,-0.052583855,-4.109948e-08,-0.017994775,-0.021789564,0.054765746,-0.07943727,-0.030400576,0.025949357,0.023726087,-0.07098006,-0.054834627,-0.04859483,0.090993896,0.072077096,0.012198697,-0.055460732,0.035005778,0.04510663,-0.03890536,0.012004809,-0.014035178,-0.05340909,-0.06644345,-0.016618066,-0.017418828,0.03690107,-0.025215033,-0.08356204,0.012513152,0.11530556,0.013770141,0.04219715,0.001688047,-0.0068540764,-0.020408725,-0.10783115,-0.11159759,0.058967106,-0.048562028,-0.09085361,0.00066656095,-0.01532539,-0.004762951,0.08381486,0.0110323215,-0.040603854,-0.06150883,0.019891325,-0.005053745,0.010175984,0.003583605,0.084568605,0.003220838,-0.015125749,-0.03214382,-0.04862594,-0.008746683,-0.013655523,-0.006683612,-0.010603852,0.04002331,-0.061624542,0.011932022,0.060171522,0.10488404,-0.026770558 +3.7.1.28,"The enzyme, which belongs to the RuBisCO-like-protein (RLP) superfamily, has been characterized from several bacterial species. It participates in the degradation of D-apionate. The reaction is initiated by decarboxylation to generate a stabilized enediolate intermediate, with the sequestered CO2 carboxylating the adjacent enediolate carbon atom. The resulting 3-ketose-1-phosphate intermediate is hydrolysed, as in the authentic RuBisCO-catalysed reaction, to generate glycolate and 3-phospho-D-glycerate. Stereospecificity of 3-oxoisoapionate 4-phosphate has not been determined.",384,0.99999994,-0.052126043,-0.091781035,-0.10203515,-0.0347048,-0.03784573,0.02953914,-0.099184476,0.0063544028,-0.017487328,0.07037705,-0.015765969,0.020416845,-0.06376182,0.06706225,-0.03655336,-0.0068212915,0.026529253,0.031603433,0.010844407,-0.0022499764,0.134003,-0.04449552,-0.04192241,-0.030563794,0.08515965,0.014044954,0.059376117,-0.06376451,-0.07030723,-0.07269762,-0.0069254297,-0.073165685,0.034301404,-0.076111786,0.076690026,0.07882277,-0.0034589295,-0.05387296,0.13986877,-0.025643032,-0.025944453,0.03779834,0.032405775,-0.024028068,-0.053063817,0.017646408,-0.016910633,0.04699394,0.10443714,-0.052584525,-0.034719303,-0.07764166,-0.05301966,-0.037625782,0.058879267,-0.029455421,0.025204996,0.046727665,0.012364624,0.041291196,0.072003976,-0.013698414,0.08443025,0.054649144,0.008647504,-0.0721877,-0.008621006,-0.04632099,-0.016624529,-0.007212924,-0.035662815,-0.038976874,-0.0010976163,0.024244748,0.037928823,0.08894334,-0.012099272,0.005663163,-0.044532157,-0.010939604,0.062044375,0.037554957,0.02581341,0.06533121,-0.031536415,0.018550096,0.053776015,-0.029060975,0.022354761,0.026589178,-0.003900495,0.037289247,0.009629074,-0.04428439,-0.024599593,0.002791027,0.009626657,0.06009136,-0.031333867,-0.07663403,-0.029022992,0.10084044,-0.0135111995,-0.10942497,-0.03576472,-0.0014396285,-0.055935767,0.0801114,0.039643917,0.020370483,-0.014512223,0.05817757,0.023200605,0.016525,-0.08136016,0.11085303,0.03172725,-0.045107782,-0.05590526,-0.0119082965,0.049978904,-0.06984854,0.02829166,0.022665773,-0.02034719,-0.007360938,-0.017340904,1.922344e-33,0.09871279,0.028258499,-0.02024929,0.009981112,0.004121873,-0.02838565,-0.10970524,-0.0157801,-0.09291901,-0.00047229938,-0.033810455,-0.011684419,0.06371501,0.036154494,-0.05780853,0.06292691,-0.05975732,0.02139698,0.006296202,0.0037895953,0.009258957,0.03224748,-0.031008285,0.04286219,-0.0144611895,0.10460688,0.0041102106,0.009373359,0.07053036,-0.031892817,0.074823596,-0.09267819,-0.10400993,0.03371874,0.026654035,-0.09538366,-0.046305407,-0.05497766,0.030410051,0.019649165,0.06436679,0.059821345,0.005514988,-0.0034792996,0.023042865,-0.028593224,-0.000716874,0.04138122,0.04389083,0.08570045,0.003677794,-0.0022627383,0.112710655,0.030518888,-0.055829514,-0.034598693,-0.020492956,-0.013834598,0.0179972,-0.0033048722,0.030086106,0.064977914,0.013704568,-0.011920889,0.037095882,-0.015988758,-0.06454001,-0.045260955,0.057358686,0.07034044,-0.013254249,-0.051327515,0.0024921743,0.004666522,-0.018498411,-0.12629645,0.02562266,-0.0050445413,-0.032302245,-0.00251999,0.017350834,-0.0047513,0.010970507,-0.048501708,0.005137493,0.025868513,-0.04250694,-0.07444145,-0.046903286,0.057245918,-0.014121453,-0.037643466,-0.10864329,0.06459778,-0.059572633,-3.2261336e-33,0.13226484,-0.07366876,0.0582476,-0.031865086,-0.10680831,0.015220039,-0.007384262,0.034481473,0.027338905,-0.035444126,0.0360738,-0.009901687,0.055352822,0.01486939,0.010668926,-0.007353165,-0.051340923,-0.005425715,-0.025199268,-0.0035302883,-0.021811273,0.06000339,0.005907747,0.022246113,0.08100242,0.035808768,-0.018635651,0.011283776,0.0045954734,0.025039842,0.07973548,0.036257822,-0.046836384,-0.02320712,-0.10408562,0.046948913,-0.075114526,-0.04036313,0.029108686,0.04927752,-0.031323332,0.055617455,-0.018257814,-0.035497203,0.09632613,0.01632795,-0.09149404,0.122847885,0.012640434,0.03148163,0.03126469,0.010205593,-0.024236934,0.022366636,0.046435267,0.009091929,0.0057588206,0.05433049,-0.020020774,-0.042378988,0.0062382813,-0.10390171,0.047294267,-0.017228745,0.026117718,0.122699715,0.016720403,0.034498956,0.046887476,0.02394699,0.07141408,0.0022195417,-0.039001614,0.010856833,0.018726734,-0.02390179,-0.09501969,0.006864451,-0.015040237,-0.005787643,-0.056911305,0.061602026,-0.014493058,-0.012813651,0.050294574,-0.10309012,0.0060843313,0.11112403,-0.027363297,0.06238667,0.00025635253,-0.05690522,-0.004778402,0.031874057,0.091163404,-4.7093163e-08,0.0846182,0.02359528,0.028611485,-0.023834908,-0.014074425,0.03866394,0.035694066,0.006931807,0.01386485,-0.03030755,-0.02161032,0.027172945,-0.024161773,-0.03301581,0.05862147,0.056338765,-0.096047826,0.027420154,-0.03693592,0.09225417,-0.010825128,-0.06500035,-0.14944865,0.056311175,-0.02586167,-0.020490173,0.118396245,-0.017739102,-0.073691666,-0.0066222753,0.004785594,0.018469911,0.05703769,-0.09520322,-0.10042057,-0.010520092,-0.06747983,0.018951282,0.00713645,0.016050076,-0.02396383,-0.0063839504,-0.048007615,-0.00673777,-0.07967629,-0.013341991,-0.00077783637,0.026385128,-0.03124774,0.020943388,0.023809336,-0.034991108,-0.049947735,-0.105407335,-0.114130415,0.020252567,-0.03028843,-0.016743788,0.00067368796,-0.00976628,-0.006857659,-0.01834763,0.1304881,-0.04616131 +4.1.2.63,"Requires Mg2+ and thiamine diphosphate. This peroxisomal enzyme, found in animals, is involved in the alpha-oxidation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids.",384,1.0,-0.06464093,-0.07958445,0.006123891,0.046374895,0.022685904,-0.030243082,-0.041148413,-0.025529563,-0.033869047,-0.0071943076,0.042089857,-0.03662487,-0.014442151,-0.00093113026,0.03583744,0.019629871,-0.009681099,0.05780212,0.027813388,-0.015432769,0.06551424,0.03251364,-0.021731079,-0.007226317,-0.024417322,0.04404182,0.07123748,-0.05187835,0.048324533,-0.02375071,-0.034443047,-0.041661426,0.104792446,-0.08319728,-0.018558145,0.09105159,-0.09757504,-0.043661352,-0.07139441,-0.01241933,0.036828168,-0.02063911,0.062395513,-0.021177463,-0.006749976,-0.11182721,0.09172751,-0.034091108,0.039235197,0.018019691,-0.07804934,-0.033582218,-0.061420526,-0.027080128,-0.006186227,-0.04672253,-0.074298635,0.0037684538,-0.04252529,0.04698983,-0.012559191,-0.0053325184,-0.0495212,-0.05440593,0.06841831,-0.030482717,0.02127291,-0.07133544,0.014256609,-0.084051654,0.006100059,-0.054637503,-0.008900328,-0.041588478,-0.10186814,0.07483917,0.022031635,-0.075563475,0.059264407,-0.01643115,-0.016295008,-0.033372287,0.025339024,0.09578815,0.07330765,-0.0035687082,-0.010311072,0.013119663,-0.08865965,0.1009536,0.11396022,0.055822868,-0.062739365,0.007913936,0.016079824,0.058509383,-0.021240622,0.014149006,-0.018010193,-0.01078662,0.010939158,0.068876125,-0.056918904,0.008562584,-0.030348213,0.061312784,-0.05259165,-0.025511976,0.024112144,0.064967856,0.033768237,0.025125796,0.007075007,0.06560771,0.0015185474,0.04214412,0.014424529,-0.104500614,-0.016544903,0.002482446,-0.04233099,-0.029435258,0.02300197,0.018521065,-0.02013754,-0.0051071225,-0.02173985,2.2460112e-33,0.010305248,0.06686163,-0.00032434796,-0.016391672,-0.066003345,0.06679183,-0.10358778,-0.018967677,0.045648865,-0.02142261,-0.045969307,-0.0099970745,-0.0017360739,0.009095729,-0.012218579,-0.09513842,0.041002613,0.0056452723,0.17593461,-0.0128550185,-0.04648703,0.06534866,-0.015490467,-0.053267438,-0.02114023,0.10368182,0.014068419,-0.044674862,0.019033873,0.018248659,0.07201444,-0.12757868,-0.06143582,-0.01163295,0.039185915,-0.04084296,-0.023454752,-0.04393059,-0.09771092,0.04979104,-0.033460863,-0.028277045,-0.03137912,0.032734077,0.050935008,-0.09301184,-0.035325855,0.108432956,-0.0051047276,0.0627186,0.06092424,0.021821987,0.03502752,-0.0071524405,-0.07418799,0.012930655,-0.010246082,-0.00066655944,0.05030612,0.05949197,0.0064769457,0.041740216,-0.02070266,0.08826697,0.058473658,-0.011769343,-0.1328831,-0.01936082,-0.0125760175,0.054752387,0.054510526,-0.053577036,0.08294872,0.0017237568,-0.0476256,-0.029640388,-0.0263264,0.081575416,0.046867676,-0.041661967,0.013270327,0.0032722938,0.028454442,0.01700239,-0.07318266,0.05915303,-0.00025467566,-0.010962605,0.03216285,-0.00031370268,0.04430688,-0.061420254,-0.045609053,0.040146977,0.056475963,-3.453136e-33,0.06718968,-0.07743486,0.08233706,-0.12518573,-0.020474235,0.011957286,0.062396858,-0.020585332,0.05325149,-0.015174017,0.041091986,-0.015988298,0.020761434,-0.08585135,0.022788769,0.034835752,-0.02657598,0.10411383,-0.044758428,-0.07704104,0.008667215,0.073243946,0.0054632295,0.14584316,0.008294414,0.028982563,0.026443727,-0.0088119,0.0065875067,0.09045664,0.0076073944,0.07230619,0.00052895735,-0.050648663,-0.01155434,0.02768997,-0.04602596,0.025122236,-0.025314948,0.07038657,-0.0040994408,0.07139222,0.05560559,0.05475671,0.039296493,0.053618636,-0.057969354,-0.02063306,0.021872101,-0.07641359,0.03662437,-0.014225244,-0.0018042709,-0.028700609,0.07510599,0.01618058,-0.05010794,0.0024221616,0.08664448,-0.061628863,-0.035100173,-0.07007156,0.057661097,-0.07002963,-0.008702861,0.025425674,0.03160263,-0.02010798,0.01711037,0.07748916,0.019521223,0.06125676,0.034366675,-0.013855378,-0.035204113,0.10642807,-0.007601904,-0.016762009,0.049959317,-0.06347867,0.030584937,0.03064754,-0.03394572,-0.035231963,-0.046050508,-0.13717577,0.013779105,0.09725636,0.026603108,-0.0129057765,-0.061671007,-0.01449212,-0.0692867,0.023322703,0.08348102,-4.0644522e-08,-0.060684577,-0.07065345,0.04882207,0.018122522,0.00047112664,0.090444885,-0.005397467,-0.024381893,0.08064433,-0.05337464,0.015526766,0.056347422,-0.023127282,0.023709724,0.014785297,-0.0059364205,0.0117522925,0.013208602,-0.0072822575,-0.024343126,-0.098872334,-0.042415727,-0.026859026,0.00817106,-0.016319022,-0.085474,-0.035804022,0.032576784,-0.001167516,0.028990356,0.019555196,0.00019006376,-0.00031760905,-0.055134345,-0.0476686,0.05483698,0.07751829,-0.033477508,-0.07199262,-0.048031762,-0.05515667,-0.04046616,0.013455919,-0.03310073,-0.021717854,-0.030277213,-0.036450922,0.08682584,-0.042829767,0.011327352,-0.006836257,-0.04903681,-0.06998004,-0.036221627,-0.036984723,-0.03153299,0.01893242,-0.036192454,-0.062270395,-0.05558899,0.0616278,0.06472872,0.13031453,-0.057327516 +4.2.1.176,"The enzyme, characterized from several bacterial species, is involved in an L-lyxonate degradation pathway.",384,0.99999994,-0.031185824,-0.06996923,-0.038226005,-0.038406227,0.11598053,0.02047754,-0.1126322,0.0314449,0.017686538,-0.022132045,0.020544246,0.017271504,0.03848373,0.052336108,-0.06250128,0.10244795,-0.10934117,-0.027424496,-0.01764931,0.026991481,0.12196808,0.06400778,-0.03343635,0.029067928,0.081470646,-0.01928019,0.0424839,-0.04626904,-0.06541943,-0.051664606,0.0035400826,0.018556116,0.10506764,-0.06442636,0.042992152,0.11778649,-0.09310144,-0.085446,0.07495123,-0.008484741,-0.037529305,-0.026011128,0.023594059,-0.06975025,-0.036550526,-0.005021963,-0.084414706,-0.003809628,-0.036686126,0.038995862,-0.062394403,-0.05316595,-0.014001997,0.016950993,-0.028335657,-0.0027504237,-0.052681003,0.02763346,-0.025971152,0.06736124,0.02829741,0.06226552,0.003985214,0.046614897,-0.016778978,-0.039778747,0.041717045,-0.024538597,0.00373202,0.013165829,-0.054619372,-0.12249135,-0.0136005655,0.016511893,0.06976787,0.03125065,0.05036419,-0.046614673,-0.040943738,-0.0075367056,0.050293878,0.028995784,-0.0023996553,0.047289073,-0.014250282,-0.023268983,0.0033758963,-0.014507564,0.03263651,0.00050381024,0.06821064,-0.0006078403,-0.029088162,-0.03398252,-0.014544335,0.015934728,0.02852815,0.0011622863,0.032155264,-0.0442457,-0.07876658,0.035632476,-0.016304301,-0.11070407,-0.038443536,-0.04105263,0.05288791,0.09914427,0.021203501,-0.08731442,0.07653152,0.004832805,0.022922356,-0.014303213,-0.012731701,0.05160389,0.053156864,-0.0100997845,-0.10420192,0.07947538,-0.012862107,-0.04820209,0.014378224,-0.012441024,-0.010636378,0.062201597,-0.0842251,-3.424665e-33,0.07018337,-0.022333184,-0.09226516,-0.0497949,-0.0005688103,-0.07454515,-0.023768773,-0.039134324,-0.066485725,-0.0076001715,-0.013779901,-0.023366518,-0.034250583,-0.0017372301,0.00736201,0.042825166,0.028175106,0.024289567,-0.000809653,0.01193825,0.027562289,0.011485097,-0.035058364,-0.008093743,0.02942798,0.09494852,0.09253645,0.025398517,-0.016374605,-0.011699761,0.020793663,-0.07450117,-0.120782875,0.009165651,0.101720236,0.04714884,-0.05271888,-0.008634987,0.022930183,0.026023516,-0.0038323877,0.08677515,-0.004399681,0.00024751556,0.060542844,-0.030732019,-0.01628587,0.08074674,0.03054335,0.030420195,0.06790013,-0.064641364,0.06692241,-0.022932867,-0.07541137,0.024323195,-0.006389701,0.002542792,0.009148038,-0.011811284,0.025495663,0.04763576,-0.04510159,0.03414557,0.07874228,-0.035513192,-0.0033756513,-0.052188978,-0.02602633,0.016369041,-0.04279767,-0.07940418,0.06873614,-0.0102167195,0.053805478,-0.05368172,-0.095915325,-0.042155884,0.04672128,0.010973118,-0.019725515,-0.050896045,-0.01997894,-0.025642043,-0.018093072,-0.013679025,-0.012109582,-0.034858454,0.018456975,0.021184172,0.037268095,-0.08246257,-0.017307725,0.05067704,-0.035601664,1.1585853e-33,0.053934526,-0.080411255,0.089221165,0.0054423106,-0.0618006,0.040283848,-0.011950186,0.029224135,-0.0036738412,-0.0049761715,0.05757296,0.03938446,-0.054091405,-0.03498755,0.033607025,0.030739713,0.050239604,-0.004483993,-0.035767876,-0.011924565,0.012196532,0.04704186,0.017871443,-0.049138106,0.05114998,0.014219636,0.035586808,0.09948989,0.06957925,-0.00904052,-0.01264051,0.009760509,0.028161915,-0.046242382,-0.017286,0.08745962,-0.020699568,-0.009254587,0.03694937,-0.034235135,0.061338894,-0.00045091825,-0.0030501636,0.0129499845,0.05777719,0.02828681,-0.034301877,0.0036128315,0.058286306,-0.05661658,0.028732907,-0.0136515265,0.01235491,-0.0059228833,-0.033815023,0.043460816,-0.0043622972,0.027833737,-0.04606454,-0.056502122,-0.03471398,-0.042892676,0.027992794,0.10058012,0.01870142,0.08983952,0.031678814,0.030981917,-0.01341717,-0.035887875,0.07840448,0.024957338,0.05850922,0.020309005,-0.05178941,-0.065532014,-0.15166087,-0.06933116,0.012361947,-0.033994544,0.054110844,-0.029809387,-0.0046813753,-0.060512178,0.047539614,-0.13597794,-0.01645389,0.10048953,0.008509503,0.026865458,0.010084575,-0.04356449,-0.06946834,-0.04655021,0.06405002,-2.4594092e-08,0.055229597,-0.022015166,-0.0026513378,-0.027482547,0.05565832,-0.005486023,-0.0003054015,0.06370117,0.084862724,0.050077382,-0.051728107,0.0710308,-0.071546294,-0.055369657,0.054984387,0.021891287,-0.010429501,0.033385813,-0.038436163,0.04021641,-0.036660824,-0.026638998,-0.059375457,0.017481236,0.028988486,-0.025596358,0.036630433,0.06383574,-0.012096598,-0.0948714,0.00079828757,0.06390361,-0.0109783625,-0.0011328976,-0.126202,0.0014115808,-0.041334584,-0.08709377,0.019649558,0.102894515,-0.054470174,0.05997866,-0.13447984,0.0034654976,-0.046005715,0.0049719033,0.037017968,-0.011519138,-0.023889562,-0.019185862,0.041065026,-0.10435523,-0.031282816,-0.039789654,-0.07406475,0.015970716,0.08230125,0.02161892,0.019106623,-0.084446505,0.00044518558,0.010839242,0.21758027,-0.06536661 +4.2.1.177,"The enzyme, characterized from the bacterium Klebsiella oxytoca, participates in (2S)-2,3-dihydroxypropane-1-sulfonate degradation. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster.",384,1.0,-0.032069877,-0.063241795,-0.13803913,0.039458636,0.025217231,0.016949926,-0.05891163,0.0035298574,0.034403186,-0.0054712784,-0.010914811,0.010237187,-0.0268112,0.011625417,-0.05675906,0.11520716,-0.073379025,-0.011017317,-0.0050940393,-0.059087493,0.038821004,0.007632106,-0.005343997,-0.037606556,0.046845473,0.033343993,0.0287223,0.0151830185,-0.071710974,-0.043584336,0.075641796,-0.009091207,0.05006579,-7.0280796e-05,0.027390651,0.10050296,-0.025308626,-0.053758767,0.04166257,0.003386934,-0.0061223893,0.0086535355,-0.060937718,0.00253489,-0.04560167,0.002907224,0.0060852235,0.040925354,0.03579488,-0.09569703,-0.050040845,-0.07963831,-0.028223589,0.020145401,0.0473736,0.042716067,-0.020115815,0.01595403,0.020240806,0.0416464,0.06409755,0.0076242727,0.015268465,0.021831656,-0.04822171,-0.048096973,0.082121246,-0.102322534,0.032801017,-0.03382346,-0.09479788,-0.06271089,-0.02467821,0.029200662,-0.027841432,0.009329827,-0.018964225,-0.03577039,0.062646426,-0.050702456,0.064399086,-0.029822227,0.024832062,0.09004335,0.016550234,-0.044439305,0.025116367,-0.083979465,0.08701001,0.011670843,0.0080602355,0.008131953,-0.007023187,-0.01473896,-0.06346315,8.9607296e-05,0.04675459,0.04154025,-0.06314704,0.03458015,-0.009330998,0.08368881,-0.045730095,-0.10670734,-0.07851153,-0.019959303,0.0113522345,0.10203682,0.0036931569,0.056871757,0.018496959,0.03398343,0.008222088,-0.026802234,-0.029563786,0.100909,0.07566765,-0.047000747,-0.07227213,-0.009899564,0.01711305,-0.0056390455,0.0081908265,0.013749156,-0.069709726,0.030687366,-0.06575588,1.1146858e-33,0.11094759,0.047675557,0.04094327,-0.023724455,-0.018931312,-0.073298946,-0.11287092,0.020019602,0.026254566,-0.053530466,-0.06696866,-0.051480275,0.043857977,0.027333146,-0.03563884,-0.0077337846,-0.02688303,0.006927327,0.069920234,0.08469687,0.00033160052,-0.0049317293,-0.046217445,0.004389645,0.0199409,0.034942728,0.055704646,0.02534443,0.013216911,0.016009245,0.007325366,-0.09498871,-0.16155007,-0.0022225813,-0.011087231,-0.031591285,-0.0832568,-0.05161183,0.02934263,0.04453094,-0.04527623,0.016050994,0.054649573,-0.040460266,0.078218386,-0.015569748,-0.017000386,0.11378068,0.04822253,0.113146976,0.019356135,-0.0706964,0.14267817,0.031432893,-0.056566846,0.072606005,0.040537525,-0.03702044,0.06103375,0.012922627,-0.0043525305,0.05248134,-0.03396752,-0.017881634,-0.006362691,0.049533576,-0.072358124,-0.04261388,-0.045108512,0.04008002,-0.021120066,0.021686113,0.025789518,0.013783183,-0.019506864,-0.04076503,-0.0018085209,0.06273305,-0.020083304,0.030753382,-0.0072822236,-0.0984351,0.027322603,-0.027937673,-0.03534847,-0.009285046,-0.023381786,-0.006609585,-0.09804055,0.004680827,0.0037564316,-0.032879766,-0.05721148,0.025579989,0.035778146,-2.642012e-33,0.09469805,-0.040435407,0.015019411,-0.06653339,-0.04067364,0.035305087,-0.052832805,0.029290872,-0.03576379,0.003699024,0.052772146,0.012648422,0.052030522,-0.088315025,0.004892895,-0.024785932,0.003003857,0.06159179,-0.042705934,0.00075423165,0.038013406,0.10625425,0.022907741,-0.02889011,0.054938506,-0.033784747,0.012912579,0.053686783,0.04496536,0.040511385,0.048197415,-0.004575277,-0.029807782,-0.034688577,-0.0074356697,0.06273496,-0.04410178,-0.043525066,0.007624092,6.328135e-05,0.004302468,0.048983585,0.018802786,0.14032461,0.065034755,0.045858026,-0.10104782,0.03256065,0.05107108,-0.10977718,0.0010167056,0.017539622,-0.005662093,0.006371919,0.025840975,0.07328513,0.022532586,0.019318294,-0.06542918,-0.043041945,-0.0726783,-0.08335922,0.07517727,-0.015245163,0.027475335,0.026919907,-0.043275826,0.060169153,0.019685712,0.029953277,0.036040653,-0.005577369,-0.042339236,0.011881213,-0.0926445,0.006087229,-0.074720934,0.049540166,-0.022716584,0.033108044,0.054097414,-0.025917316,0.021578837,-0.09989909,-9.860362e-05,-0.12034012,0.012407115,0.10671383,-0.00671334,0.035013646,-0.033385914,-0.013164569,-0.095723055,0.046120014,0.0009776254,-4.2332864e-08,0.010430276,-0.043714277,0.039672524,-0.03723065,0.0475557,0.047311604,-0.004867438,0.04925133,0.054241475,-0.04781071,-0.028486665,0.11619534,-0.012648079,0.026490051,0.020127751,0.0551372,-0.061839454,0.011963517,-0.018763935,0.03188218,-0.015187748,-0.10773879,-0.115037955,0.08686028,0.05298054,-0.056173068,0.053000636,0.0060720006,-0.025702935,-0.019079093,0.017094307,0.036401827,-0.02260768,0.027421424,-0.11141764,-0.0015136965,-0.090019904,-0.016770452,-0.043150045,0.060488,-0.012800378,0.0040711537,-0.08215807,0.048709568,-0.01547906,0.044650357,0.008454783,0.031452257,-0.0730957,-0.026957816,0.065952346,-0.014681375,-0.03878971,-0.034173634,-0.13111705,0.05641594,-0.029850805,-0.021015506,0.03931052,-0.023335636,-0.009554297,8.2325394e-05,0.14111577,0.030442469 +4.4.1.38,"The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, participates in a taurine degradation pathway that leads to sulfide production. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.",384,1.0,0.0018144074,-0.032215845,-0.036611363,0.046928007,-0.011854941,0.014629911,-0.012949646,-0.0123749925,0.061399765,-0.018022958,-0.01892261,0.040013153,-0.023578687,0.04849478,-0.06437512,0.14826712,-0.042980433,-0.004828687,0.013995366,-0.08340434,0.04079652,0.046372946,-0.009972318,-0.0038035307,0.0017410578,-0.009288372,0.053676862,-0.042269334,-0.04561449,-0.008712724,0.04004004,-0.05404863,0.08358228,-0.02171805,-0.008007592,0.08068924,0.018988349,0.014497897,0.041952528,-0.015301727,0.050257675,0.0056652557,-0.048347346,-0.03578303,-0.019488687,-0.02182667,-0.019254725,-0.0044510276,0.05232743,-0.0079200445,-0.07153683,-0.023788387,-0.048937984,0.07348749,0.06701224,0.06281444,-0.06714633,-0.056169357,0.04711097,-0.060090158,0.05403595,-0.004335033,0.0077712615,-0.048831426,0.053451154,-0.016303632,0.043408226,-0.030330973,0.07854889,-0.04236504,-0.07057617,0.0055682533,-0.03463875,-0.0024313903,-0.0131011475,0.02399753,-0.027638493,-0.06595789,0.05974409,-0.051593017,0.012166416,-0.02070678,0.03480407,0.06330733,0.08681238,0.0014118282,0.044860043,-0.051762525,0.03349562,-0.031074103,-0.030251551,-0.04633517,-0.020707091,-0.06981446,-0.0151821505,0.011550915,-0.025103547,-0.00552332,-0.044739217,0.011203411,-0.01428025,0.05442434,-0.041788794,-0.13297895,-0.08610494,0.009702358,0.009131987,0.12365278,-0.005151139,0.014162697,0.0071518477,0.03271696,0.0326687,0.026750892,0.019392963,0.08214795,0.069967955,-0.031985622,-0.10814776,0.068735525,-0.020287639,0.050843097,0.00898464,0.018593034,-0.01574454,0.02448546,-0.086638406,-4.2642762e-35,0.115131766,0.085090004,0.055106767,-0.0097270785,-0.0011553791,-0.06794638,-0.09866788,-0.041396096,-0.0011957417,-0.031554952,-0.018855797,-0.08665917,0.021360107,0.05308009,0.0025290337,0.011281727,-0.006868514,-0.00014185243,0.11566734,0.017802961,-0.10528166,0.02605703,-0.021636136,-0.06040246,0.023895549,0.042876776,0.0044979355,0.027820772,-0.0055170227,0.03247593,0.0362561,-0.044695564,-0.108166784,0.027173694,0.010086379,0.02600891,-0.07285232,-0.05796284,0.028258363,0.052118585,0.014820669,-0.017315274,0.06326663,0.0038047002,0.017028375,-0.040750474,-0.006686518,0.06461014,0.0945881,0.12351519,0.028516699,-0.07340221,0.1113422,-0.080050796,-0.07702507,-0.050917286,0.040380616,-0.0619108,0.016208068,0.07842215,-0.026445635,0.043562934,-0.06883748,0.025032064,-0.027901478,-0.024350788,-0.038262926,-0.060390826,-0.054715894,0.08035256,-0.03351986,-0.03626537,0.014901262,0.04920452,-0.05221263,-0.07049471,0.014382509,0.052827593,0.0411871,-0.012406163,-0.064363845,-0.06576271,-0.039592847,-0.031228123,-0.056208376,0.019735707,-0.031226845,-0.062080465,0.03600322,0.045212697,-0.019274836,-0.017873093,-0.08136357,0.06788433,-0.0062956484,-1.1708401e-33,0.040192284,-0.0647187,0.0016444799,-0.05664939,-0.08709198,0.054568447,-0.011715501,0.023839036,0.022702843,-0.017449144,0.09240469,0.04636488,0.032644264,-0.04321239,0.062444124,-0.004698439,0.122685984,0.0025485917,0.02293643,-0.07398669,-0.0023162428,0.121440254,0.0022426057,0.0059233224,0.03844194,0.03957055,0.0458153,0.040466584,0.10998526,0.046749577,0.02392321,0.011048832,-0.036707517,-0.012849545,-0.00714667,0.025234113,-0.0122169275,-0.0068295165,-0.006438673,-0.05114706,0.00030742126,0.047316894,0.0147449905,0.1224861,0.03595018,0.059386414,0.008796889,0.028173624,-0.00277352,-0.10179435,0.06322929,-0.03942242,0.013839154,-0.0050331834,-0.018587321,0.059324447,-0.027280169,-0.04405482,-0.029935054,-0.055723894,-0.07330325,-0.04437979,0.027380984,-0.07045061,0.0013011792,0.007975374,-0.01748041,-0.017866923,-0.043266594,-0.024152832,0.032337494,-0.031276222,0.010322597,0.032390703,-0.09454431,0.004491451,-0.09649779,0.051194444,0.01698507,0.026353765,-0.0016718959,0.04137389,-0.0055893147,-0.087308615,0.023388905,-0.11317719,-0.03692444,0.17933026,0.050296973,-0.0059342473,-0.059867386,-0.00013882192,-0.08621836,0.0067747957,-0.0026842284,-3.5415184e-08,0.0045285537,-0.039801713,0.016537616,-0.0041502356,-0.044301786,0.06839082,0.040677413,0.033055138,0.026215764,0.013921214,-0.06390735,0.11471126,0.0060461005,-0.005094643,-0.013597308,0.064576425,-0.041250873,0.018173791,-0.035351686,-0.048427336,-0.07135016,-0.03583818,-0.061079364,0.08180661,0.016580816,-0.06543797,0.101835236,0.0004606347,-0.08092773,-0.04430331,0.07297375,0.0076582595,-0.036553334,0.02666727,-0.09611757,-0.0043436475,-0.008032419,-0.004879367,0.049151532,0.049877726,-0.005579619,0.06512295,-0.08909238,0.029568575,-0.01000238,0.005099837,-0.01783766,-0.019238148,-0.08555809,0.014421616,0.045349028,-0.041567747,0.01997077,-0.04774997,-0.10890779,-0.015729595,0.017978529,-0.106059745,0.0352497,-0.037144452,0.071157575,0.018185057,0.14003718,-0.0012545373 +4.4.1.39,"The enzyme, characterized from the cyanobacterium Microchaete diplosiphon, catalyses the attachment of the phycobilin chromophore (3E)-phycoerythrobilin (PEB) to cysteine 82 of the alpha subunit of the phycobiliprotein C-phycoerythrin. The numbering used here corresponds to the enzyme from Microchaete diplosiphon, and could vary slightly in other organisms. Activity is greatly enhanced in the presence of the chaperone-like protein CpeZ. The reaction could also be catalysed by EC 4.4.1.29, phycobiliprotein cysteine-84 phycobilin lyase, but much less efficiently.",384,1.0,-0.12757541,-0.028630652,-0.037256844,-8.484114e-05,0.060768235,0.036465824,-0.043800306,0.019235447,0.0102037415,0.029597174,0.060917407,-0.033436727,-0.050597794,0.071637854,-0.07465556,0.075363725,-0.06505809,-0.016703542,-0.012579499,0.03266147,0.05282762,0.027921101,-0.06343592,0.036685675,0.0405704,-0.046476472,0.013481552,-0.019226242,-0.06948231,-0.020791277,-0.011395358,-0.080104694,0.062016133,-0.05179232,0.104067005,0.054288916,-0.0035500515,-0.14041272,0.07798405,0.022277802,0.062628545,0.000992321,-0.0079264315,-0.046261117,-0.04205245,-0.0014764693,0.028703518,-0.004976577,0.03639651,-0.0035553684,0.00029705712,-0.024709197,-0.033962946,0.049432483,0.0029413651,0.015227399,-0.09739429,-0.007844243,0.024897985,-0.0053674765,-0.036469605,0.021351038,0.0038624953,0.0034897681,0.011817327,-0.088738084,-0.04161272,-0.09601712,0.0636943,-0.053148963,-0.06548005,-0.064137086,0.026046699,0.05362265,0.014533039,0.028326673,0.049302287,0.004236129,0.007070636,-0.013428282,-0.0008504246,-0.060333166,-0.023645297,0.055925038,0.024702791,-0.039129525,0.05818494,-0.023904607,0.060175855,-5.7344445e-05,0.08817735,0.06995257,-0.044518773,-0.0787305,-0.100020796,0.060831066,-0.008279882,-0.02461923,-0.013671366,-0.0061513553,0.04423596,0.038854767,0.044705562,-0.12219459,0.013792441,0.019393872,0.026220951,0.04922279,0.0881722,-0.019253658,0.0031532673,-0.01806402,0.016612718,-0.0020115594,0.0047734156,0.05282728,-0.025674667,-0.019688744,-0.013423741,-0.012065208,0.016678099,0.015487167,0.05318015,0.06432212,-0.04488121,0.081650436,-0.04948462,6.0809987e-33,0.08788463,-0.013286234,0.028058615,-0.00509202,0.010588035,-0.010635176,-0.08834251,0.09445098,-0.0065010088,-0.108609535,-0.01971925,-0.065519325,0.07254443,0.0035063727,-0.058765948,-0.039336927,-0.03216932,-0.015934795,0.087039195,0.056170337,0.03086976,0.022786591,0.0072264494,0.028242163,0.044423304,0.044524297,-0.040629685,0.02648717,0.04132591,0.006050364,-0.01205382,-0.08034824,-0.10431059,-0.034589592,0.024451949,0.018304022,0.019710843,-0.11060277,-0.0030982464,0.06466926,-0.03740023,-0.03447184,-0.0065501346,-0.06030811,0.020210106,-0.007783644,-0.01589631,0.033352192,-0.030457847,-0.002039964,0.033835612,-0.050454274,0.09236655,0.019690493,-0.05156242,0.017180555,-0.018411795,-0.012846148,0.08380009,-0.00332713,0.031033665,0.10580682,-0.030861774,-0.036505137,0.017630232,0.025517112,-0.042739306,0.022148114,-0.008150387,0.052666333,-0.045343526,-0.033045154,0.023608238,0.012537855,0.041053534,-0.030723484,-0.05407869,0.00012200831,0.015625367,0.034722995,-0.007959708,-0.029253036,-0.039266653,-0.02355162,-0.011916353,0.009518747,0.049253378,0.0048404485,-0.0079669515,0.0045389445,-0.025645802,-0.07382508,0.015832743,0.023378907,-0.038757283,-6.426615e-33,0.12074377,-0.16077285,0.012189148,-0.025217485,-0.014445464,-0.039386388,0.018330062,-0.024204249,-0.04767452,-0.09403202,0.025535017,-0.0562036,0.06455098,-0.0027546375,0.057711042,0.13127926,-0.08656023,0.04930354,0.022602214,0.045827117,-0.0095751295,0.029567594,0.08538896,0.10271771,0.05904115,-0.01904282,-0.00117681,-0.00067141175,0.062981255,0.048175283,-0.12035268,0.0017961966,-0.037567917,-0.029552842,-0.07422334,0.07199777,-0.059947312,-0.032597303,0.13525607,0.028329859,0.03746278,-0.020321185,-0.06972194,0.051161647,0.028724596,0.06238225,-0.05128762,0.05409394,-0.05310188,0.039927464,0.016527712,0.037510272,-0.023623668,0.024875933,-0.036351517,0.10639119,0.05347353,0.02944267,0.024592914,0.0006952967,-0.08285027,-0.05315749,-0.04004577,0.019702999,0.09123151,0.13884506,-0.0054402803,0.08368615,-0.012752705,-0.06483921,0.10459448,-0.03767945,0.13236095,0.00019847181,-0.008980435,0.059562564,0.0039859596,0.009450869,-0.016543372,0.05301073,0.011796241,-0.015961574,0.03182447,-0.051884487,-0.0514565,-0.037354518,0.022419842,0.04544955,-0.04376222,-0.02606863,-0.049868383,-0.017645655,0.04212626,0.067472905,0.11543391,-4.2497092e-08,0.066928945,-0.041335676,0.017395275,-0.05720622,0.05183561,0.028619789,-0.032260682,-0.052108645,-0.016342599,-0.027998714,0.029203894,0.008939158,-0.05221451,0.032060105,0.05404025,0.055117294,-0.020321088,-0.030835707,-0.012721669,0.03170505,-0.06652426,-0.003789108,-0.10753267,0.08291027,-0.041921947,-0.024564356,-0.011602241,0.017220596,-0.10284433,-0.02847424,-0.022569962,0.03019691,-0.08004016,0.011228444,-0.010798995,0.09215331,-0.06480392,-0.06142149,-0.0030271974,0.036178578,-0.058302302,-0.039524097,-0.07456392,-0.039285157,-0.04550277,-0.030118832,0.021910487,0.030015737,-0.029599613,0.029741716,-0.0052176886,-0.06789914,-0.015160505,-0.023774311,-0.045643415,-0.018441284,0.0050962954,-0.046068083,-0.09975863,-0.006180474,-0.030374732,0.037607145,0.1634318,-0.047005493 +4.4.1.40,"The enzyme, characterized from the cyanobacterium Microchaete diplosiphon, catalyses the attachment of the phycobilin chromophore (3E)-phycoerythrobilin (PEB) to cysteine 48 and 59 of the beta subunits of the phycobiliprotein C-phycoerythrin. The enzyme first ligates the A ring of PEB to cysteine-48, followed by the attachment of the D ring to cysteine-59. The numbering used here corresponds to the enzyme from Microchaete diplosiphon, and could vary slightly in other organisms. The reaction requires the presence of the chaperone-like protein CpeZ.",384,1.0000001,-0.13427956,-0.04282685,-0.042761613,0.0055939946,0.025074346,0.028541293,-0.042186935,0.027682278,0.020612095,0.046380784,0.072100446,-0.053169187,-0.05510847,0.055039193,-0.10888051,0.06947624,-0.09876304,-0.027504425,0.013968008,0.06422857,0.0681786,0.04647149,-0.057392392,0.039271288,0.04984043,-0.024444846,0.013907728,0.008892727,-0.0526407,-0.017686052,-0.028681027,-0.070003,0.054682467,-0.040609207,0.13559799,0.03876851,-0.010998672,-0.109049805,0.07113127,0.018845355,0.0816766,0.0026365835,-0.015689291,-0.027126763,-0.038681682,0.016301814,0.014182282,0.024551546,0.023197593,0.0072935177,-0.012241979,-0.04061871,-0.041272085,0.077477016,0.017858231,0.01005135,-0.086243436,-0.008122137,0.037665524,-0.017156512,-0.048020564,0.0017185957,-0.028982721,0.007318413,0.036583237,-0.0905516,-0.054388847,-0.09376334,0.05061916,-0.044069584,-0.05158944,-0.07663211,0.009103669,0.03234566,0.027652588,0.014884182,0.052809093,0.003095613,-0.0072958004,-0.008854432,-0.025228187,-0.04735943,-0.011670164,0.054957073,0.019215152,-0.028384924,0.0732645,-0.0048368075,0.03273057,0.00988822,0.051145412,0.067258306,-0.06508575,-0.08837334,-0.115985215,0.064667575,-0.0006751875,-0.0010267245,0.012025944,-0.00983448,0.039672464,0.029439136,0.03974966,-0.1266472,0.00015252865,0.018102735,0.010255072,0.040428855,0.09371964,-0.015689641,-0.0040039457,0.005112103,0.0043307026,0.0047616195,0.02225717,0.035013907,-0.029026348,-0.025507621,-0.006273575,-0.021132056,-0.014926965,-0.0004961454,0.0034534421,0.06627062,-0.07025493,0.084817424,-0.073051594,4.6658148e-33,0.10639737,-0.04146787,0.00892424,-0.012433492,0.02168772,-0.01709289,-0.075023785,0.08034558,0.005425835,-0.10083682,-0.029435314,-0.09431554,0.065805264,-0.0043890756,-0.0752047,-0.021846727,-0.041028105,-0.021629162,0.08543423,0.067347966,0.028682109,0.046778698,-0.01106596,0.029092724,0.05436811,0.048214205,-0.06644141,0.045281917,0.031128619,0.0038912767,0.009065659,-0.07732619,-0.09909616,-0.030535892,0.057641983,0.009985153,0.035717677,-0.1025311,-0.015108807,0.06722397,-0.03399174,-0.04694225,-0.036601186,-0.028243154,0.033551827,-0.019085145,-0.0025684661,0.039124556,-0.014076536,0.008144317,0.05068334,-0.049444772,0.124145,0.015688948,-0.03666711,0.032315534,-0.028914995,-0.01963342,0.059820034,-0.010294259,0.03597466,0.09198845,-0.020602947,-0.0028852685,0.045344923,0.05607592,-0.047731664,0.041757386,0.0027556652,0.06253838,-0.08458002,-0.024617115,-0.010474939,0.007621813,0.014701715,-0.015836533,-0.071183205,-0.0004384375,0.013405883,0.032635834,0.013272271,-0.03307311,-0.050542176,-0.03288872,-0.027543202,0.027176091,0.043557473,-0.025688825,-0.0029520656,0.010461145,0.006296491,-0.07942669,0.0127767185,0.03207423,-0.010623161,-5.344623e-33,0.11689746,-0.16949132,0.0056940312,-0.022171244,-0.03972967,-0.010205791,-0.004985967,-0.022284834,-0.04403836,-0.08151186,0.020448325,-0.052152354,0.03720232,-0.012481065,0.02344951,0.11582932,-0.05372996,0.049921233,0.014745647,0.015895173,-0.010133401,0.05177657,0.07460551,0.088576265,0.027515508,-0.008275206,-0.009175533,0.009664092,0.055993143,0.029349724,-0.09273829,0.005190177,-0.008085291,-0.02457448,-0.05454305,0.065868445,-0.068758376,-0.02847685,0.15637296,0.041940607,0.03177492,-0.027951434,-0.049693555,0.08255515,0.02493428,0.06014968,-0.052448478,0.03442372,-0.08223804,0.00911869,0.0020844825,0.041957222,0.005432158,0.017239079,-0.023884885,0.07700514,0.04948365,0.022230107,0.043849036,0.0005307529,-0.06201355,-0.07158768,-0.039507262,0.023894837,0.09060742,0.12343115,-0.009179569,0.07781727,-0.0136058135,-0.043606736,0.07724171,-0.0016706496,0.10025217,-0.008878751,-0.034187905,0.048174135,-0.003697923,0.024825845,-0.008651097,0.043648086,0.0157447,0.013612236,0.019160492,-0.0333757,-0.060723644,-0.030416511,0.032864943,0.044466764,-0.051032446,-0.023544615,-0.047497295,0.0038918636,0.05555286,0.07840733,0.10152761,-4.455627e-08,0.07438124,-0.038769506,0.031665936,-0.03642973,0.050377633,0.048511337,-0.027286254,-0.040875312,-0.025188059,-0.015557805,0.016428892,0.016237224,-0.032272726,0.026356032,0.07749656,0.030727401,-0.0024039717,-0.049735907,-0.013351766,0.03042811,-0.087099716,-0.01492265,-0.10346135,0.097188406,-0.037249878,-0.03426058,0.0056777555,0.03507175,-0.108521655,-0.00083541655,-0.01494106,0.013472419,-0.098101124,-0.020996418,-0.038216595,0.10379799,-0.06160031,-0.07966438,0.019389318,0.007280285,-0.038602024,-0.016946614,-0.077871375,-0.031789083,-0.05023275,-0.017386073,0.033675615,0.012041327,-0.041746352,0.033142895,-0.0046677296,-0.05343241,-0.021250537,-0.016378012,-0.07995155,-0.010052705,0.025464607,-0.04246201,-0.1007527,-0.005434659,-0.04073887,0.06614729,0.15557559,-0.040116053 +4.4.1.41,"The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster.",384,0.99999994,-0.007063649,-0.033684194,-0.09463002,0.06573788,0.027349774,0.0009707209,-0.032588486,-0.015995542,0.016069954,0.0016110117,0.031525083,-0.012791657,-0.046481144,0.057553284,-0.05013416,0.13340826,-0.047298573,-0.033103213,-0.006489223,-0.08021659,0.039190874,0.088003226,0.023347791,-0.030561844,0.013218304,-0.055341017,0.07371589,-0.05738095,-0.013073708,-0.039473463,0.061040048,-0.017013498,0.13375945,0.0014402838,0.010223731,0.10998155,0.02486073,-0.007558945,0.10196362,0.014327898,0.019473497,-0.032127526,-0.021185102,-0.013246338,-0.054300886,0.009595196,-0.0010393442,0.0007173364,0.047921646,-0.00092034007,-0.057556935,-0.032765526,-0.04528044,0.033615574,0.064031385,0.029583061,-0.0155299585,-0.010842114,0.069585584,-0.035407,0.10432692,-0.017011076,0.058049068,-0.016905202,-0.0058693234,-0.010345491,0.043699726,-0.07180079,0.07238973,-0.09157878,-0.051726174,-0.011485251,-0.037181936,-0.009127323,-0.013777669,0.012565979,-0.00794903,-0.038101505,0.04038801,-0.007423595,0.017530287,-0.042368215,0.062139172,0.08086832,0.059793107,0.049679,0.028042987,-0.006851423,0.00079112226,-0.00451864,-0.045972712,-0.088791505,-0.0016328632,-0.07494169,-0.049272582,-0.0218361,0.012549173,-0.07202965,-0.036788736,0.00017486165,-0.06169704,0.07152845,-0.0071722823,-0.08375286,-0.11378485,-0.017242733,0.018981963,0.10531966,0.01237111,-0.0011461434,0.013971231,0.065891445,0.058123447,0.0069233603,-0.0347334,0.015413301,0.04018357,-0.055141695,-0.04378008,0.07724774,0.04050973,0.055047657,0.029528258,0.05153763,-0.021556748,0.027175272,-0.09811089,9.682748e-34,0.09109402,0.071655855,0.022003734,-0.022104494,-0.004480943,-0.055907432,-0.08762487,-0.019919163,-0.017119233,-0.06119092,-0.03557038,-0.07331819,0.07207874,0.10495678,-0.035487503,0.017174918,-0.039553512,-0.02194125,0.091980055,0.03395482,-0.098164566,0.012214773,-0.062771216,-0.031717163,0.009384741,0.03259892,0.0083597265,0.06917998,0.07435633,0.014237357,-0.017927907,-0.057958994,-0.10577117,0.026079718,-0.00968021,0.045572933,-0.049520265,-0.108826205,0.030476626,0.050193302,0.01689887,0.0031266126,0.050748736,-0.015658883,0.05742547,0.017472416,-0.076733,0.07677687,0.06437975,0.13136293,0.046667133,-0.0371645,0.11213261,-0.06903023,-0.10221752,-0.013456491,-0.00019567086,-0.026727935,0.026394032,0.09320307,-0.038170233,0.042528454,-0.040708184,0.047502063,-0.018663293,0.0069711353,-0.04242623,-0.07848634,-0.047143146,0.06883789,-0.025951352,0.0098590385,0.04774062,0.040163793,-0.0415635,-0.07395615,0.044529982,0.03452436,0.02097847,-0.018082893,-0.04959948,-0.07353697,0.022890726,-0.06618684,-0.024671447,0.015340111,-0.07578654,-0.04691785,-0.015115339,0.03129914,-0.061057407,-0.057561904,-0.05614247,0.04800499,-0.0065571237,-2.027046e-33,0.03822563,-0.044030968,0.030059315,-0.027103025,-0.060679484,0.047971755,-0.0390421,-0.0059003993,-0.025261048,-0.018653626,0.105138615,0.014794919,0.037019048,-0.054094754,0.06805639,0.014220088,0.07191309,-0.005122429,0.04454389,-0.02161117,-0.017970555,0.08802056,0.012536594,-0.056350753,0.038571164,0.04411682,0.0041302075,0.045851145,0.057902034,0.03514195,-0.008381055,0.010470154,-0.040363774,-0.016829705,0.013856676,0.058285374,-0.041898806,-0.038164586,0.020182015,-0.04121051,-0.03625467,0.056611184,-0.010406923,0.108762085,0.025593799,0.073964745,-0.030918548,0.031263042,0.019074082,-0.09583295,0.009912035,0.030818405,0.01978783,-0.03136149,-0.029423395,0.098427445,0.0232259,-0.01674632,-0.017003361,-0.08611722,-0.05719866,-0.066229686,0.065808736,-0.011942822,0.020134507,0.017830823,-0.028023055,0.0032634602,-0.07400535,-0.024366466,0.01898156,-0.0139832245,0.021887159,0.07207917,-0.08720117,-0.016951954,-0.06964591,0.00069017557,0.025796324,0.03592745,0.016523464,0.016876949,-0.017406493,-0.07593801,0.010279833,-0.09967968,-0.03162695,0.14369385,0.03715641,0.0049499515,-0.082044385,0.036685955,-0.08465121,-0.0032513097,0.07214005,-3.742836e-08,0.045800082,-0.073082946,-0.0061677764,-0.064118244,0.013071907,0.046713807,-0.0055243955,0.01767794,-0.01884752,-0.018405553,-0.05610314,0.09907241,-0.06746645,0.022827258,0.006992089,0.03602392,-0.053308222,0.005992208,-0.024098895,0.008807954,-0.07410147,-0.01893133,-0.06849346,0.0580197,-0.028823795,-0.057883218,0.113629706,0.005250667,-0.03583571,-0.010038084,0.025634646,0.041858777,-0.03350716,0.029370762,-0.13565938,-0.024101725,-0.04938875,-0.012523033,-0.028993305,0.07655555,0.015045449,-0.005137699,-0.049135923,0.01590259,-0.04900088,-0.029911643,-0.008365449,-0.0118231755,-0.03491556,0.019994557,0.043254267,-0.025677089,0.031497397,-0.0061268667,-0.09905245,0.008293566,-0.024969215,-0.10135745,0.013286687,-0.017317886,0.032439515,0.058422435,0.16301385,-0.0094608255 +6.2.1.69,"The adenylation domain of the enzyme catalyses the activation of L-cysteine to (L-cysteinyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0,0.0100659,-0.07568726,-0.045982167,-0.05184447,0.038034152,0.040348608,-0.02624809,0.053636085,0.13035074,0.021458155,0.045022734,0.00993075,0.05853043,0.05730231,0.020440787,0.012796096,-0.08539512,0.002107957,-0.010330992,-0.060423892,0.035515033,0.026174143,-0.025537807,0.076971374,-0.020472547,-0.029310418,0.037274316,0.013544362,-0.021617524,0.0075084036,-0.06682167,-0.044441946,0.000118227304,0.033319112,0.043659333,0.11535437,-0.048006143,-0.02430565,0.027724212,-0.014037386,0.02790365,-0.06275851,-0.011157058,-0.003689091,-0.018814893,0.06434458,-0.013066639,0.12880982,0.0367342,-0.01420912,0.008025922,-0.063352406,-0.03185347,-0.028391685,-0.08238237,0.13516463,-0.068594806,0.022937912,0.020861281,0.012812774,-0.056424443,-0.0009963985,-0.028298697,0.011187175,0.030040003,-0.11336101,-0.01048407,0.0030520556,-0.038449433,-0.0064027575,0.014500459,-0.07780561,-0.023219397,0.053182226,0.08582359,-0.008345092,-0.048300292,0.00093823177,-0.06387626,-0.030994572,0.09344192,0.0074838116,0.023366125,0.043802984,0.018170133,0.014783376,0.023701565,-0.0111273,0.007702076,-0.016408274,0.06902922,-0.07385606,0.010502093,-0.0211486,-0.07190613,-0.026613293,0.039333783,-0.012557215,-0.00089096546,-0.011184515,0.012303189,0.030088263,-0.045808554,-0.053926095,-0.020494988,0.026514491,-0.01990131,0.10181824,-0.030259112,-0.045936212,0.013659467,0.031409718,0.0634834,-0.055636592,0.010487407,0.08050148,-0.025808712,-0.054528642,-0.010241452,-0.0507264,-0.026157966,-0.030808197,0.0010432189,0.10959321,-0.056462146,0.008601934,-0.08393554,1.9672308e-33,0.05012888,0.021725504,0.066606544,0.012361508,-0.063995615,0.04627777,-0.022394286,-0.0012072629,0.04578478,-0.03848952,-0.055290274,-0.021400701,0.004869183,-0.046274778,0.0007357543,-0.028700925,-0.07792982,0.06620762,0.06453007,0.095671944,-0.04539764,0.050317343,-0.010186087,0.041378807,0.03561455,0.06559065,-0.04734193,-0.07414158,0.04134008,0.009419858,-0.08547944,0.012575404,-0.0747965,-0.014294033,-0.016724097,-0.039485555,0.002794468,-0.043657865,0.042007785,0.023325086,-0.06182358,-0.056405324,-0.015208181,-0.056640927,0.011140012,-0.036942866,0.002141436,0.057707682,-0.09946724,0.010486809,0.093780346,-0.041696962,0.107244164,-0.053276658,-0.058672614,0.006736314,-0.04183715,-0.077396184,-0.016063849,0.06573014,0.06777436,0.04753421,-0.04962143,0.0063340175,-0.06198797,-0.0042917407,-0.057320986,-0.14054394,-0.008822364,0.17683521,-0.013345572,0.058125522,0.083167605,0.050180774,0.021013152,-0.022059131,-0.101019844,0.048717324,0.0026735617,0.057993893,-0.013380416,0.014841156,-0.03710287,0.038432334,0.040715996,-0.05103307,0.06791866,-0.06983064,-0.08811624,0.023816077,0.013381572,-0.036421243,-0.019367862,0.09731869,0.0072964313,-3.5468893e-33,0.10012537,-0.14271076,0.025636228,-0.06072893,-0.07431918,0.03642267,-0.0104189245,-0.05543442,0.03789163,-0.0133018745,0.017867211,-0.006487127,-0.082858585,-0.028448446,0.041121975,-0.044707935,-0.047721904,0.016045097,-0.07334076,0.017932061,-0.050009537,-0.028387224,0.036531985,0.0735098,0.052296847,-0.018246591,-0.06880228,0.10111703,0.0401534,0.025887327,-0.057959463,-0.048294906,-0.034352694,0.008447877,-0.032513328,0.11469145,-0.04288359,0.04294699,0.07252285,0.028514078,-0.014223393,0.033903264,-0.009364055,0.064275615,0.008091644,0.098666936,-0.020701578,0.06598776,0.031052575,-0.091455676,0.03945908,-0.05043034,0.07189238,-0.011214684,-0.009791034,0.061495386,0.010964674,0.03325254,0.025125995,-0.020607766,-0.04730572,-0.07419277,-0.064956695,0.03500339,-0.02958427,0.026271397,-0.036229026,0.033436097,0.03424763,0.06024211,0.035961337,-0.0034441834,0.0558124,0.023254732,0.007840015,-0.007280105,-0.027123595,-0.0683724,-0.026877843,-0.05573478,-0.03623419,-0.015151333,0.0056210086,-0.02670925,0.020915654,0.01961043,0.05955618,0.0670227,-0.013728802,0.037034392,-0.0026556808,0.024682455,0.04947503,0.015707176,0.032481678,-3.863741e-08,0.049135637,-0.0541863,-0.020371078,-0.123184904,-0.025212072,0.044001773,0.00657076,-0.037146594,0.0025072803,-0.022113541,-0.049644873,0.041611005,-0.025050864,0.05068327,0.012265686,0.07721764,-0.0050886786,0.050934974,0.021463433,-0.029820826,-0.067511655,0.046276186,-0.094529495,-0.0018368104,-0.015447899,-0.024464779,0.080494694,-0.0008074158,-0.012244605,0.03987221,0.10474952,-0.029447068,-0.042052526,-0.0011243238,0.019586852,0.030743139,-0.044849057,-0.01331669,-0.034996063,-0.03446188,-0.031419102,0.031397793,-0.072270416,-0.0086005945,0.018538635,0.009512512,0.036216255,0.035429154,0.04149029,0.01834379,-0.0011420882,-0.007773817,-0.013832688,-0.09044318,-0.059363287,-0.0234526,-0.019917915,-0.13016108,0.04822443,-0.10136794,-0.021709708,0.040123325,0.20274465,-0.012675206 +6.2.1.70,"The adenylation domain of the enzyme catalyses the activation of L-threonine to (L-threonyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein (as in the case of DhbF in bacillibactin biosynthesis), or of a different protein (as in the case of PmsD in pseudomonine biosynthesis). This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0,-0.045922194,-0.10061812,-0.088695064,-0.04879231,0.029819699,0.012973921,-0.06182513,0.07825101,0.13468541,0.015310531,0.00782783,0.017222457,0.033131953,0.031963926,0.035779122,0.046418354,-0.08195924,0.001901668,0.04043401,-0.05236118,0.0706862,0.05331449,-0.01816712,0.017697237,-0.022484627,0.0067718877,0.023603458,-0.0023817718,0.0121474555,-0.0016717892,-0.031688605,0.0012200531,0.011987834,-0.005276934,0.063639976,0.123292476,-0.051612146,-0.018943265,0.08013699,-0.047792442,0.075896725,-0.062492933,-0.021913055,-0.03156376,-0.03355144,0.056215532,-0.004261595,0.113710664,0.016972521,-0.042369857,-0.017564645,-0.05286474,-0.06564165,0.010146764,-0.07413848,0.09166294,-0.045688886,0.014303694,0.016446017,-0.0076959906,-0.085493505,0.008312497,-0.0027121908,0.029183695,0.03806258,-0.09442742,-0.018529557,-0.0010240328,0.004657643,-0.013216997,0.007385047,-0.05865169,0.004381665,0.08101175,0.07582267,-0.007547204,-0.025445174,0.0108250445,-0.051785763,-0.0634088,0.065379016,0.019674812,0.057302933,0.0849177,0.0015277363,-0.0016762292,0.03163156,-0.011390844,-0.0044932584,-0.029127669,0.052095268,-0.070273355,-0.006470988,-0.02217634,-0.06364761,-0.0141014205,0.019973824,-0.022577379,-0.02974043,-0.0017344083,0.019203132,0.028276097,-0.06026561,-0.058208268,-0.0067852456,0.051166296,-0.028927412,0.09769064,0.023795344,-0.019978225,0.0044215466,0.032577023,0.07033301,-0.029167423,-0.011004917,0.04349144,-0.024620844,-0.05717519,0.02375443,-0.10910567,-0.038473304,-0.040879484,0.041812982,0.10929183,-0.057917006,0.009241117,-0.08114499,2.701959e-33,0.053833008,0.021937175,0.07426367,-0.052441746,-0.07066194,0.019902892,-0.046150923,-0.027346287,0.06267709,-0.020075023,-0.05968435,-0.058529284,0.016334487,-0.04005568,-0.0029400664,-0.051027723,-0.07538197,0.09434092,0.08408378,0.04349776,-0.07311525,0.04241276,-0.038852647,0.049837753,0.050879937,0.06003465,-0.008965822,-0.057560503,0.043801147,0.015732728,-0.061645452,0.004995157,-0.066570364,0.002102891,-0.011897317,-0.01095708,-0.016275952,-0.05662605,0.012192746,0.019537224,-0.060387064,-0.051223125,-0.035406616,-0.05497892,0.0056877327,-0.026827289,-0.005301958,0.07612421,-0.09072459,0.02315163,0.055989515,-0.063398086,0.12793937,-0.068720795,-0.057286363,0.016559841,-0.018823974,-0.08822352,0.014252642,0.05958537,0.07226883,0.008855908,-0.044937026,0.010903833,-0.061530717,0.020177213,-0.06396307,-0.11860254,0.006124073,0.15185557,0.011450877,0.073222615,0.08093935,0.04171724,0.03181595,-0.014785434,-0.07870841,0.052724145,-0.025137268,0.06575646,0.0054450715,0.023404589,-0.05330714,0.027628304,0.022427307,-0.030287733,0.0481797,-0.08903762,-0.08334097,0.020901965,0.027920263,-0.06654465,-0.045167148,0.11650771,-0.028467095,-3.9893027e-33,0.060339235,-0.13251826,0.015346046,-0.0508665,-0.06876247,-0.010123552,0.024799561,-0.0034460998,0.039725665,-0.034612283,0.013604322,-0.03120175,-0.07310835,-0.07081816,0.02128028,-0.03673617,-0.04250689,0.012020372,-0.0628055,0.03621671,-0.007746998,0.017516695,0.003267729,0.078510046,0.046526037,0.0059311176,-0.07946147,0.10569034,0.034124848,0.05062252,-0.01659825,0.01215136,-0.066285245,-0.024621326,-0.051043823,0.090043485,-0.044561964,0.05027698,0.05875298,0.0029500895,-0.0122799,0.06453201,0.00064631645,0.056346964,0.026991274,0.09216074,-0.017513305,0.024206556,0.02979771,-0.10323297,0.0047514243,-0.05306821,0.08238685,0.00034595965,-0.025508868,0.07446699,-0.002368587,0.04322077,0.020769937,-0.06593182,-0.051964957,-0.09737909,-0.008100234,0.040311836,-0.034692343,0.041295566,-0.034906026,0.040538073,0.05961066,0.037353344,0.04371745,0.00042675954,0.025291134,0.0133785475,0.0034598822,-0.012683689,-0.037778784,-0.10981361,-0.06264757,-0.051764194,-0.06307017,0.0016997546,-0.01976785,-0.039983712,-0.024144398,0.029624697,0.070370495,0.086076245,-0.02920457,0.045714878,-0.022330815,0.04088336,0.030825395,0.053168215,0.012032061,-4.39921e-08,0.028377438,-0.049603153,0.016759332,-0.056925777,0.005983656,0.03428686,-0.016160186,-0.026719904,0.020161089,-0.026106926,-0.088584684,0.04158822,-0.06546034,0.02475833,0.003413649,0.10201534,-0.03116258,0.022285897,0.006932778,-0.07669116,-0.053760674,0.034323435,-0.08489238,0.040070366,0.00090028957,-0.008644874,0.06963161,-0.02142224,0.024295308,0.024948133,0.06626833,0.045937795,-0.032354183,-0.023406107,0.01781583,0.03866476,-0.015999991,-0.024575843,-0.027912399,-0.03293917,-0.021333598,0.026760973,-0.044583354,0.023925979,0.040058184,0.020038923,0.043035336,0.07213577,0.013656506,-0.04351221,0.012726865,-0.012083481,-0.034519527,-0.07688177,-0.059143595,0.026650531,-0.04502804,-0.090314716,0.052151307,-0.042351782,-0.019679703,0.026847616,0.2094254,-0.009180448 +6.2.1.71,"The adenylation domain of the enzyme catalyses the activation of 2,3-dihydroxybenzoate to (2,3-dihydroxybenzoyl)adenylate, followed by the transfer the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein domain of a specific non-ribosomal peptide synthase. For example, the EntE enzyme of Escherichia coli is part of the enterobactin synthase complex, the VibE enzyme of Vibrio cholerae is part of the vibriobactin synthase complex, and the DhbE enzyme of Bacillus subtilis is part of the bacillibactin synthase complex.",384,0.99999994,-0.05179259,-0.11914158,-0.07961848,-0.0787299,-0.0049085077,-0.032248214,-0.07117864,0.05104291,0.06732305,-0.028265199,-0.0069657383,-0.08433513,0.014755971,0.027357066,-0.02193814,0.02541149,-0.044377867,0.02764828,0.024384698,-0.025564294,0.09137304,0.08713046,-0.024051413,0.012959327,-0.048087496,-0.0025994342,0.063549444,0.035964888,-0.014450962,-0.01561868,-0.04869249,-0.021510702,-0.0056778607,-0.0014252142,0.115305714,0.08020573,-0.0033733633,-0.064662255,0.08088693,-0.023067173,0.036256783,-0.009172136,0.035624467,0.003359683,-0.018024996,0.057335753,0.03674885,0.07440643,0.0805321,-0.096015036,-0.058178853,-0.077437215,-0.05171632,0.011345115,-0.0069453046,0.038204167,-0.017488636,-0.05879494,-0.00068645366,0.015147273,-0.031048313,0.020824067,0.05822398,0.013599473,-0.0050167227,-0.072110474,0.039121374,0.014856106,-0.07871109,-0.02051151,-0.09106957,-0.04900274,0.00497879,0.0714093,0.024412815,0.023514885,-0.02686403,0.035018556,-0.03729887,-0.081177406,0.08266776,-0.020132223,0.075495414,0.1177951,-0.010741947,-0.023798257,0.07585196,-0.024172172,0.044996206,0.017233804,0.024972323,-0.083254814,0.012156119,-0.06888874,-0.010944523,-0.03968693,0.02016053,0.0056179245,0.05488219,-0.0057554734,-0.04887177,0.010173917,0.009977771,-0.05762118,0.0045084213,0.00063657603,0.028912243,0.16807409,0.033287346,0.017444197,-0.06484155,0.05633462,0.11890463,-0.015842192,0.02901046,0.019665703,0.032615043,-0.012235336,-0.021438316,-0.021183828,0.0120708775,-0.032662746,0.0749986,0.05006323,-0.0721594,-0.0006519101,-0.08151632,5.2087984e-33,0.03581838,0.02134185,0.0656565,-0.008932903,0.00013026192,0.016183062,-0.07593579,0.015416868,-0.045137618,0.0102317715,-0.10742162,-0.092604846,0.0753764,0.021412633,0.013544199,-0.015430526,-0.08407933,0.042529445,0.0083404975,0.001960752,0.024409527,0.0013901448,-0.018441847,0.03526551,-0.032618314,0.024480809,-0.03442642,-0.016076973,0.0155493,-0.037185587,-0.02021193,-0.017749192,-0.09936775,-0.019779319,0.017292444,-0.015832901,-0.013260598,-0.04530428,0.014221768,0.02386796,-0.023826865,-0.021653323,-0.061374437,-0.08979511,0.07435552,-0.010273469,-0.033096552,0.09409556,-0.0064602606,0.049327597,0.047992416,-0.022715624,0.09437516,-0.120166026,-0.030267542,0.026307926,0.062432796,0.0066582593,0.0063006114,-0.016119218,-0.015415843,0.03416019,-0.043435823,-0.0066848104,-0.06757864,0.0066346796,-0.015715184,-0.14079347,0.043838535,0.0901538,-0.07057364,0.0747689,0.017979667,0.032533336,-0.017846249,-0.06096527,-0.115850866,-0.040653218,-0.006000934,0.049826525,-0.019660885,0.01215753,-0.006037647,-0.024244858,0.03936433,-0.0426081,-0.004617626,-0.023520106,-0.108033545,0.044416375,0.038185485,-0.064448796,-0.04591634,0.03702737,0.07073055,-6.080554e-33,0.09410224,-0.06912278,0.01159778,-0.09627884,-0.05828117,0.009251377,0.015921568,0.016042726,0.05634371,-0.023680463,0.012600829,-0.0006573375,-0.01722432,-0.031307317,0.0021049567,-0.005789702,-0.024960775,0.00047711798,-0.0062739067,-0.0719325,0.022203032,0.05158188,0.044071678,0.019186068,-0.0062965923,0.024014875,-0.03666434,0.16289996,-0.018505642,0.06503581,-0.034674827,-0.020770807,-0.04047349,0.02025509,-0.070523165,0.084286384,-0.058354843,-0.009547793,0.0464996,-0.01728248,0.01687578,0.09674062,-0.013782172,0.035755876,-0.036195062,0.14211784,0.009351159,0.022495143,-0.0005589271,-0.08454763,0.008788484,-0.04397684,0.084507704,-0.019701319,0.02137039,0.055104017,0.008697955,0.00050906563,-0.020838302,-0.013984053,-0.051540285,-0.025605679,0.04010527,0.031225365,-0.032610476,0.06211586,0.0011415518,0.06618407,0.08161946,-0.05896155,0.066472866,0.029846393,0.0101828175,0.013180128,0.024865607,-0.047961097,-0.039208636,-0.041007392,-0.059250742,-0.085882954,-0.008793411,-0.014860007,-0.038330782,-0.01443472,-0.040950097,0.04303953,0.032780476,0.09377286,-0.0037203005,-0.010301187,-0.027946236,0.04848951,0.047409765,-0.0014670434,0.025166852,-4.2641854e-08,0.06338255,-0.06528634,0.036073618,-0.0841724,0.02573344,0.05860705,-0.00425759,0.039893854,0.045311406,-0.012784788,-0.021957444,0.048699178,-0.06234658,0.057868067,0.014149192,0.07083919,-0.0505959,0.0021718438,-0.029916141,-0.05056416,-0.00684934,0.024480697,-0.10643645,0.06955664,0.045012288,-0.054060083,0.00037014324,-0.023019927,-0.016352253,0.031103013,0.03163523,0.035509933,-0.016517865,-0.02915686,-0.051170647,0.007837446,-0.04477853,-0.02807545,-0.016647227,-0.029193604,0.08310088,-0.0004083849,-0.062115096,-0.01827198,0.026549334,0.09599245,0.009707031,0.061873514,0.032821722,-0.07787806,0.030870102,0.02516677,0.0066340305,-0.016275888,-0.14792235,0.017648375,-0.017754221,-0.087613106,0.023869442,-0.028987516,-0.028423203,0.003485269,0.21957494,-0.033393614 +6.2.1.72,"The adenylation domain of the enzyme catalyses the activation of L-serine to (L-seryl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,0.99999994,0.013349217,-0.08239804,-0.06826612,-0.06333008,0.017503,0.0500613,-0.009165598,0.047227368,0.14017935,0.009714777,0.034579966,0.027253944,0.02811341,0.050635356,0.054850053,0.0040894193,-0.111342244,-0.00048451405,-0.0064594424,-0.06347261,0.091521956,0.04082734,0.007818963,0.048328985,-0.041467343,-0.021111675,0.009581518,-0.0040497985,-0.0002550098,-0.020845188,-0.025334034,-0.019176032,-0.004975948,0.007969365,0.05359418,0.064978436,-0.018319378,-0.034275666,0.029401809,-0.013894885,0.03622173,-0.068664975,-0.031147355,-0.023402404,-0.0434543,0.024291793,-0.014626921,0.10565659,0.03604956,-0.024496885,-0.013317353,-0.09276355,-0.05709739,-0.04674007,-0.089409254,0.124398686,-0.06761822,0.011474502,0.0344017,-0.014906871,-0.07420478,0.03610966,0.0005783815,0.0030357419,0.05280498,-0.11839495,0.003586387,-0.025700182,-0.013420733,0.009029034,-0.010653923,-0.10826562,0.0045703277,0.08065156,0.08439548,-0.022255424,-0.044240095,0.029442761,-0.040988576,-0.016624743,0.08212412,0.0147098135,0.008726349,0.08447562,-0.004412377,0.013858343,0.014614056,-0.025965653,0.05306125,-0.027735043,0.053598728,-0.12971511,-0.0028093155,-0.0024167204,-0.05294982,-0.038392797,0.03533174,-0.020231007,-0.027341329,0.0128842415,0.00951696,0.018419992,-0.03581662,-0.054274954,-0.008506728,0.036255136,-0.030679258,0.10759745,-0.038261287,-0.06595299,-0.0010182449,0.025275787,0.06033745,-0.027670793,0.003526566,0.05964641,-0.031481273,-0.07191371,0.013358573,-0.091315955,-0.031233989,-0.015068386,0.033406332,0.11549939,-0.0415989,0.029715994,-0.096535526,1.5194939e-33,0.06932225,0.015494093,0.098600805,-0.018803226,-0.0864167,0.013661659,-0.03550865,-0.0022683067,0.05973264,-0.026709024,-0.08201788,-0.02942237,0.027209325,-0.050645515,0.028957684,-0.039321844,-0.07399543,0.10232525,0.07184192,0.08336662,-0.058781125,0.07505049,0.02920747,0.029200712,0.02226568,0.037542123,-0.070857026,-0.08225469,0.05241108,0.025894754,-0.043553412,-0.0017859954,-0.049459007,0.012382927,-0.015869938,-0.007524566,-0.017154766,-0.05035008,0.04241363,0.034701142,-0.04530065,-0.046379574,-0.013034857,-0.028198127,-0.0041342964,-0.03910945,-0.00797361,0.06966457,-0.07594251,0.041814458,0.0633282,-0.057973664,0.094540745,-0.058290046,-0.067021765,0.030332837,-0.034673754,-0.05215015,-0.008792651,0.062290438,0.06156888,0.010769734,-0.028596643,0.0017145631,-0.029123263,0.0042078374,-0.06210585,-0.103511505,0.013813595,0.17076866,-0.028484108,0.07461889,0.08729012,0.05964262,0.036068548,-0.025315749,-0.09368901,0.056664072,-0.03826337,0.065534174,0.020209918,0.014262516,-0.0786453,0.030698668,0.042019613,-0.03464311,0.06122715,-0.0775219,-0.09144536,0.033652507,0.0010816599,-0.038101826,-0.02124803,0.08922726,0.030674502,-3.3543837e-33,0.078904465,-0.14962418,0.01934995,-0.04193124,-0.08469639,0.008675167,0.025958598,-0.039764408,-0.0011817303,0.023532897,0.00845701,0.0026980203,-0.045050267,-0.08225949,0.019179653,-0.059944946,-0.039969556,-0.0033462131,-0.03517816,0.024041194,-0.044665348,-0.003475506,0.018114708,0.07883595,0.04203563,-0.024898726,-0.066605955,0.10629515,0.0203678,-0.0013434864,-0.010651211,-0.041693896,-0.038788415,-0.0063962047,-0.04998787,0.08488894,-0.034798507,0.042628378,0.077800184,0.005608473,-0.0050712666,0.04472123,0.03059357,0.051304013,0.03757547,0.09667332,-0.025041116,0.03603278,0.044196215,-0.08514555,0.017056735,-0.055557434,0.08054273,-0.038152505,-0.003954302,0.066025324,-0.003844899,0.035822682,-0.0015431506,-0.0016257162,-0.040510505,-0.05901472,-0.04736682,0.042543642,-0.023659157,-0.0016807084,-0.03962326,0.029533425,0.049589824,0.037199404,0.039419197,0.016504634,0.049876045,0.016070316,0.020475788,-0.036857173,-0.04218978,-0.09149903,-0.039027195,-0.091556236,-0.05588949,-0.022508128,0.004380098,-0.055392,0.015676312,0.04862866,0.046936028,0.09192038,-0.010565629,0.047531474,-0.0030827848,0.0037815238,0.009834692,0.017957292,0.016579267,-3.8930928e-08,0.04426371,-0.041667372,0.0002055218,-0.061712377,-0.021702431,0.05945601,-0.011575888,-0.052004013,0.01199463,-0.033431105,-0.048142113,0.04547692,-0.038944904,0.033840604,-0.00737882,0.074388914,-0.030219326,0.05834332,0.0026274766,-0.0737965,-0.059302084,0.031777374,-0.05755434,0.0352164,0.023732878,-0.0069263806,0.068105124,0.020884212,-0.004179744,0.009925019,0.08987753,-0.022862885,-0.03986511,-0.010261692,0.027118383,-0.0034014385,-0.033172507,-0.015277299,-0.014080692,0.0060592997,-0.003317005,0.03684583,-0.05282678,-0.003706248,0.039465565,0.072274536,0.04570937,0.038993593,0.0012230132,0.00022261204,0.01578903,-0.011244483,-0.02871451,-0.05515418,-0.081792615,-0.000530847,-0.04224576,-0.12875675,0.06633567,-0.075133756,-0.019390762,0.046601,0.19818495,-0.014783204 +6.2.1.73,"The adenylation domain of the enzyme catalyses the activation of L-tryptophan to (L-tryptophyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0,0.026468707,-0.068536185,-0.06429473,-0.06927457,0.030851535,0.043912202,0.011626674,0.039182328,0.13050663,0.039005827,0.05513028,-0.019604107,0.0132924225,0.08475696,0.027776212,0.028846921,-0.08125758,-0.030192573,0.012706121,-0.06102655,0.049358785,0.061600067,-0.0089966245,0.03595004,-0.06368517,-0.040696412,-0.010907252,0.023068877,0.016254736,0.0016371565,-0.05377412,-0.018713973,-0.030846892,0.006882606,0.061889116,0.10054662,-0.02549564,-0.029786928,0.028489703,-0.022668201,0.023507092,-0.05244147,-0.036821418,0.00014614669,-0.041652765,0.070585124,0.011351534,0.13091497,0.039232794,-0.047925018,0.0019882338,-0.076189935,-0.03930299,-0.04115878,-0.052463815,0.15507449,-0.042833544,0.020138813,0.031584427,0.022901291,-0.058947377,0.017702794,-0.001059809,0.0077725863,0.061744668,-0.104855895,-0.026724739,-0.024600204,-0.01986844,0.019080224,-0.012762133,-0.07868173,-0.015991436,0.074408025,0.081059,-0.02472054,-0.035569053,-0.0027174866,-0.05849286,-0.05060462,0.057477478,0.014107219,0.009444318,0.07795726,0.003499949,0.020295199,-0.020997245,0.009715188,0.030220494,-0.049265705,0.060998037,-0.109068625,0.009368746,-0.00853203,-0.03717662,-0.0028723348,0.014038549,-0.09252383,-0.016434314,0.0045037605,0.01517435,-0.026179709,-0.052520007,-0.07973199,0.001933456,0.034476515,-0.0038646117,0.09522457,0.0135674365,-0.039692145,-0.020716889,0.022596546,0.075866446,-0.022467043,-0.010799205,0.04515438,-0.031833544,-0.0758179,-0.0049365447,-0.086580865,-0.024706349,-0.019300252,0.010581176,0.10306054,-0.05829576,0.005614897,-0.084243834,2.3506518e-33,0.085136876,0.010070753,0.07254863,0.015240397,-0.07958327,0.04955638,-0.0078311525,-0.016903646,0.05425767,-0.0050440077,-0.088079855,-0.08014492,0.008210516,-0.025899904,0.029392667,0.0042152475,-0.124226116,0.09592343,0.03115549,0.08924995,-0.08859799,0.05706913,0.003964196,0.0015753082,0.044616576,0.07028999,-0.06481072,-0.082953654,0.076847106,0.00013509343,-0.05288047,0.016098578,-0.10671507,0.025126193,-0.014182459,-0.023059268,0.0058403723,-0.027627472,0.0130207315,0.022256572,-0.04531305,-0.00576806,-0.029283246,-0.015010411,0.0444375,-0.0028276127,0.017769258,0.07194173,-0.045099318,0.03603386,0.07100314,-0.047302365,0.08426019,-0.06373276,-0.08208807,-0.0052260845,-0.026065933,-0.053139247,0.0037305306,0.045661304,0.020377036,0.010898768,-0.03516664,-0.005289969,-0.05925061,0.011111519,-0.03906014,-0.1441236,0.0166136,0.13184813,-0.023663076,0.055256456,0.08025703,0.033781912,0.029162351,-0.044704977,-0.055912495,0.030848473,-0.019292472,0.05712531,0.059564505,-0.014988872,-0.043490242,-0.011425364,0.009845439,-0.04652993,0.06291609,-0.1009269,-0.06890261,0.0029966654,0.03193071,-0.0036720214,-0.033082053,0.1049507,0.016007759,-3.4738407e-33,0.074630946,-0.15505354,0.037620835,-0.05205517,-0.05564533,-0.00917601,-0.0056189178,-0.06387962,0.0106997555,-0.022268673,0.04309117,-0.035873327,-0.034681838,-0.050075002,0.03684607,-0.063391,-0.05559104,0.056880493,-0.03555112,0.0014133834,-0.04299997,-0.02744276,0.016507916,0.053043026,0.050342593,0.020041494,-0.0873217,0.07639558,0.046877537,-0.012132154,-0.011778771,-0.063896865,-0.08761465,0.025394585,0.0071777846,0.081350565,-0.055103403,0.067620195,0.04735828,0.008603194,0.031171467,0.049546707,0.04340469,0.024642266,-0.014975074,0.11512226,-0.037816785,0.04416058,0.025841711,-0.09800909,0.031741537,-0.07320853,0.04434689,-0.0066145626,0.022764971,0.07984453,0.016566224,0.04662432,0.0022559224,-0.028035978,-0.07136595,-0.060791954,-0.01936185,0.044385802,-0.033531398,0.049003642,-0.01302636,0.046895403,0.039721895,0.074894756,0.03135446,-0.0033889594,0.071124695,0.009722109,-0.021772018,-0.031531617,-0.02266069,-0.13806339,-0.0273838,-0.06683344,-0.014541167,0.004041379,0.0016506846,0.014878482,0.014201145,0.032327835,0.040534154,0.09304799,0.003930567,0.039021928,-0.0008441318,0.02906979,0.06690624,0.031928204,0.056734238,-4.0253184e-08,0.04300426,-0.05689499,-0.01904412,-0.09523471,-0.028361922,0.03171215,-0.00516086,-0.037234467,0.033879057,-0.03401266,-0.042708367,0.03886752,-0.034168895,0.029330404,0.0011453145,0.054818653,-0.016030189,0.037913125,0.02433134,-0.043681517,-0.09919397,0.021497812,-0.057029646,0.004181285,-0.010925334,-0.0032871738,0.081118636,0.038956,0.02457914,-0.0035818594,0.06458123,-0.012433262,-0.04497872,0.009936524,0.015137117,0.053728838,-0.052933574,0.018032799,-0.05105921,-0.03337089,1.4931769e-05,0.00059282366,-0.025799634,-0.0054536327,0.015622841,0.0073969294,0.03239512,0.018258391,0.038621455,-0.0048064487,0.0097647635,-0.0021714068,-0.011694012,-0.053868532,-0.088533014,-0.016117359,-0.05632369,-0.114105664,0.03166198,-0.07858645,0.01633135,0.056991268,0.19250286,0.014792791 +6.2.1.74,"During the biosynthesis of most ansamycin antibiotics such as rifamycins, streptovaricins, naphthomycins, and chaxamycins, the activity is catalysed by the loading domain of the respective polyketide synthase (PKS), which transfers the substrate to the acyl-carrier protein domain of the first extension module of the PKS. During the biosynthesis of the mitomycins the reaction is catalysed by the MitE protein, which transfers the substrate to a dedicated acyl-carrier protein (MmcB).",384,1.0,-0.064467154,-0.02927459,-0.10192264,-0.026518574,0.0023043854,0.008060007,-0.040748958,0.07742926,0.10665476,-0.024417723,0.030134246,-0.0032192548,0.12558557,0.028147949,-0.049522497,0.04074961,-0.07100991,0.07652224,0.030604813,-0.05381091,0.059381977,-0.031849347,-0.0014004664,-0.050050806,0.03163911,-0.045125563,0.002330556,-0.03186331,-0.021758184,-0.07403036,0.035933156,0.01822972,-0.01843518,-0.04914752,0.079764344,0.12944753,-0.085421786,-0.054529,0.111477286,-0.024422001,0.044550214,-0.047489844,0.029602513,0.022871548,-0.021886135,0.0643671,-0.021436807,0.018470872,0.019779466,-0.019396244,-0.01792343,0.0069549363,-0.039529078,0.062177386,0.030157458,0.047819182,-0.035742126,-0.0062544444,0.016157875,0.01372537,0.0026818211,0.007855918,0.010956073,0.004452455,-0.083495766,-0.073983,0.027782341,-0.024828436,0.02139835,-0.02704687,-0.08784485,-0.0359593,0.0066445265,0.048598923,0.093460575,-0.03593049,-0.061627217,0.020190448,-0.1121558,-0.0334649,0.008390796,-0.033997882,0.093681246,0.06579583,0.070971765,-0.022660958,0.07331223,0.021572879,0.028958123,0.08663912,0.02493875,0.0019783324,-0.015723595,-0.027919447,-0.058407247,-0.031827386,-0.015287409,0.026971644,0.01723362,-0.020850968,-0.034007918,0.013445547,-0.0018732256,-0.0053525297,0.0178022,-0.035921704,-0.04190726,0.05381645,0.0295393,-0.033684973,-0.028339088,0.009503826,0.025593454,-0.051416695,-0.009690016,0.09850185,0.021269977,-0.05545801,-0.023358796,-0.063500844,-0.015972301,-0.012367061,-0.05513674,0.059408437,-0.031184165,0.004284751,-0.115091674,7.157511e-34,0.030312153,0.07535655,0.012774743,-0.008977546,-0.07210876,-0.04042691,-0.04402149,-0.09057963,-0.0035100156,-0.06177702,-0.04704525,-0.068155736,-0.030549997,0.04929917,0.012268987,-0.057474487,0.012425115,0.047229446,0.011276025,-0.0016011671,-0.03983618,0.030364595,-0.009703104,-0.0020043643,0.086659454,0.08697466,-0.005848776,0.0011890815,-0.01376894,-0.022688385,-0.08354837,-0.01666209,-0.03338851,0.017732883,0.053828377,-0.04975693,-0.018758565,-0.03876009,0.065414436,0.040018458,-0.04143109,-0.041822318,-0.026377376,-0.055718727,0.023942858,0.016764445,-0.053982873,0.046748802,0.011943063,0.03900631,0.059256688,-0.026954794,0.10454102,-0.007887491,-0.07642022,0.03295308,-0.06791611,-0.07629796,0.013403256,0.006849696,0.026691508,-0.071694046,-0.0443925,-0.012053289,0.038399786,0.07735987,-0.04344295,-0.031396747,-0.007785918,0.07982536,-0.093419716,-0.007693343,0.052094806,0.053902045,0.07293166,0.05410388,-0.09900558,0.038663045,0.06354761,0.050672118,0.031477265,0.057652254,-0.06620566,-0.03956134,-0.021395236,-0.039394356,-0.03287981,-0.10438257,0.010121786,0.014795104,-0.022249034,-0.08367805,-0.013547222,0.054878972,0.016992921,-3.881749e-33,0.1467357,-0.037810374,0.0023351333,-0.06882176,-0.0662094,0.053103894,0.028248945,0.0018493326,0.030322028,0.022862284,-0.021632388,-0.022792961,-0.11113575,-0.05959304,-0.051085833,-0.0055607203,0.059035,0.104679756,-0.04122769,-0.015493227,-0.016945018,0.04594138,0.0339889,0.06663335,0.0017660413,0.04688507,-0.071400665,0.05553829,0.058008727,0.053783577,-0.02285022,-0.057947215,-0.04356617,-0.006091033,-0.02726637,0.0635979,-0.088302515,0.047068413,0.042664662,0.010715006,0.08374462,-0.038201176,-0.017785478,0.030413562,0.04975272,0.00062105554,-0.0685376,0.034959435,-0.005333441,-0.13426384,0.018538892,0.055616874,0.090004615,-0.04900116,-0.036101576,0.0666055,0.07204649,-0.0019782374,0.050214406,-0.05382773,-0.06545765,-0.045757238,0.038777348,-0.0086678015,-0.08969506,0.05906115,-0.027929863,-0.008635653,0.05961301,0.029938946,0.03934089,0.018164843,-0.0062113637,0.00054674264,-0.020919537,-0.01847317,-0.037734475,-0.0832579,-0.0067563993,0.0031581144,-0.031750247,0.032251693,-0.028327657,-0.039508257,-0.053228796,-0.0028045864,0.08251724,-0.034117308,0.06690715,-0.049579654,0.048673805,0.042174015,0.019681154,0.0933551,0.00732223,-4.0409713e-08,0.05054785,-0.006608712,0.04138898,-0.006513958,-0.007413832,0.020652648,-0.026573094,-0.004836833,-0.013201739,-0.027906047,-0.013429973,0.0499213,-0.007081186,0.00030343092,0.012849905,0.06801831,-0.028030397,0.03612891,0.016843028,-0.029764937,-0.06583321,0.024639836,-0.06723888,0.08321242,0.02333888,-0.03661065,0.0063277823,-0.04013296,0.0043105325,0.051410083,0.06001955,0.018996976,-0.0779142,0.01789136,0.0021538548,0.020415917,-0.05473476,-0.1024642,0.08884637,-0.0014092984,0.02908218,0.029911434,-0.026536744,0.053283915,-0.027351985,0.05611001,-0.026611874,-0.04934999,-0.037194453,0.03198371,0.06604812,0.021956852,-0.079243526,-0.08430856,-0.10538528,0.05522728,-0.02418444,-0.07672516,-0.004875309,-0.12961417,-0.06720805,-0.043595552,0.21895882,-0.024253443 +6.3.4.25,"The enzyme, characterized from a number of bacteriophages, participates in the biosynthesis of dZTP, which replaces dATP in the genome of these phages.",384,0.99999994,-0.15531494,0.010613715,-0.045671105,-0.040359475,0.018814433,-0.017291684,-0.018847352,0.054159056,0.03715224,0.035489537,-0.050772227,0.031030888,-0.040844895,0.043445718,-0.0020628031,0.030285064,-0.09300745,0.042197216,0.013160777,-0.058697682,0.016115412,0.1110115,-0.009217645,-0.025311884,0.03202554,0.022750288,0.036130343,0.06002697,0.022164851,-0.04054146,-0.004460918,0.012811735,-0.007688099,-0.07374137,0.0362946,0.08780164,0.0012908351,-0.027053388,0.02984637,-0.047355514,0.09706866,0.08763003,-0.08164409,0.008296049,-0.030926943,0.06564046,-0.06334301,0.10562853,-0.0498365,-0.050520528,-0.06779752,0.009597365,0.01620808,0.05800843,-0.01933394,0.012851161,-0.011809335,0.01790256,-0.016768742,-0.02379019,-0.0068210764,0.008550038,0.002110748,-0.001002662,0.08448274,-0.08206882,0.025088957,-0.025180997,0.04301503,-0.070881344,-0.13868937,-0.03606749,-0.07219824,0.06924281,-0.047541246,0.03087493,0.048040025,-0.08908806,0.019481659,-0.018219389,0.0427914,0.015862152,-0.016082125,0.08417707,0.037870992,0.0030700339,-0.00196627,0.004978181,-0.0027024543,0.011828916,-0.0073867547,-0.09437746,0.017827548,0.0031599838,-0.09380754,0.06509537,0.050906677,-0.0311767,0.088328764,-0.007876788,0.043839782,0.029715959,0.0021224807,-0.053190853,-0.028688058,-0.041695103,0.01685323,0.033023056,-0.025365157,-0.02762014,0.06133705,0.011109341,0.0481497,0.009773946,-0.037643317,-0.013210149,-0.035143834,-0.047057245,-0.05888611,-0.02087693,-0.018889742,-0.06923194,0.009832664,0.06309392,-0.054326717,0.008769243,-0.09392308,-1.8806205e-33,0.025434138,0.02557931,-0.030427543,-0.026726594,0.042414013,-0.0064157406,-0.06683491,0.025045564,-0.078383535,-0.03622211,-0.0885998,-0.114054084,0.04531317,0.017342068,-0.08273095,-0.058127016,-0.03609619,0.069133796,0.06383997,0.05082075,0.040719904,0.10204472,-0.07789,0.015084928,0.10163988,0.061847877,-0.059285164,0.037186015,0.017926976,-0.018977307,0.025983822,-0.085431404,-0.09500118,0.024766615,0.044779144,-0.012846822,-0.010789348,-0.088162184,0.013432115,0.012050513,0.01309158,-0.022332594,-0.079070754,0.08485077,0.045700237,0.033746395,-0.048641287,-0.0007663252,0.028860645,-0.025995726,0.0716407,-0.015143823,0.07186952,-0.07997023,-0.10195726,-0.008301306,-0.071928315,-0.07530662,0.048390042,0.07068879,0.0053531216,0.02440702,-0.1142774,0.06532661,0.063331954,-0.06258966,0.0028520513,-0.031809054,0.059014503,0.106901854,-0.021706205,-0.045876067,0.0932837,0.03440783,0.0006083002,0.013801021,-0.013843444,0.050418995,0.03164478,0.062302656,-0.0275314,-0.0029062796,-0.06418803,0.012363158,0.0026586035,-0.025557412,-0.03489634,-0.052183922,-0.031997558,-0.058130194,0.12717246,-0.078066766,-0.016171321,0.017254416,-0.022067161,-1.3459586e-33,0.026389632,0.012055468,0.0033290875,0.0012468614,-0.0018716763,-0.0015394223,0.038739987,-0.04341177,0.0338161,-0.027717963,0.073650606,-0.0837121,0.00030781637,-0.046262287,-0.012674564,-0.018827355,-0.007122684,0.032997258,-0.06546291,0.033355527,0.02976816,0.07818597,0.06500412,0.050912544,0.02937464,-0.005906735,0.0066903685,0.035544887,0.03235101,0.04470013,0.0281687,0.0715793,-0.072008245,-0.036102552,-0.024295785,0.049818914,-0.05446869,0.064173184,-0.02643513,-0.0026046806,0.062609404,0.049154963,-0.024007263,0.087835446,0.04462204,0.063186534,-0.039416302,0.064775415,0.058913395,-0.051757496,0.026115734,0.05669313,0.033137184,-0.017847678,0.025793001,0.047199775,0.032335773,0.057986706,0.032062463,0.011330017,-0.026990557,-0.074333854,0.07272024,0.042600878,0.022115007,0.039962824,-0.008569891,-0.02206163,0.06513709,-0.07554101,0.03711893,0.03699544,0.0235369,-0.032950312,-0.08689474,0.01850401,-0.14587049,-0.062741466,0.028948901,0.040082168,-0.03989275,0.005640942,-0.0037178898,-0.010327235,-0.028862493,-0.056886762,-0.019910596,0.07738285,-0.017708309,0.029764377,-0.055755608,-0.0145166805,-0.034335654,0.016924948,-0.020299828,-2.990763e-08,0.06592143,-0.08788534,0.005325313,-0.028538054,-0.00955563,-0.011074109,-0.04630144,0.011865389,0.10510339,0.022593284,0.027465284,0.059308987,-0.04580528,-0.0010153662,0.108638376,0.06558461,-0.034182277,-0.025509588,-0.0103623,0.001819569,-0.044691157,0.02558944,-0.14105633,0.07855591,0.033484668,-0.023446526,-0.011309482,0.050272107,0.07530195,-0.062081013,0.026860274,0.00510178,-0.01008914,-0.0077138934,-0.023047995,-0.020493135,-0.024071777,-0.09638099,-0.029416468,0.02987181,0.014348547,-0.017927753,-0.030681603,0.031484712,-0.07243139,-0.008339285,-0.008783182,0.038100027,-0.033710122,-0.05221245,0.029640527,-0.034877744,-0.027134024,-0.073383935,-0.042669967,-0.002580235,-0.016440915,-0.07025176,-0.05721079,0.03147434,-0.021015156,0.0882469,0.1888148,-0.06165053 +7.1.1.11,"This iron-sulfur and flavin-containing electron transport complex, isolated from some anaerobic bacteria, couples the energy from reduction of NAD+ by ferredoxin to pumping protons out of the cell, generating a proton motive force across the cytoplasmic membrane. Most similar complexes pump sodium ions rather than protons [cf. EC 7.2.1.2, ferredoxin---NAD+ oxidoreductase (Na+-transporting)].",384,1.0,-0.10065488,0.017879732,-0.11866363,0.0725351,0.069540575,0.020570377,0.043694742,-0.0020948683,0.020807417,-0.037030328,-0.012744529,-0.059426904,-0.008903171,0.066293366,-0.059901267,-0.056817424,-0.0236654,0.009828895,-0.03427874,0.06482354,0.00880858,0.011398759,0.06229995,-0.034120917,-0.015522521,0.060971018,-0.0014147628,0.015047352,-0.02896856,-0.094963215,-0.030404722,0.0055804546,0.0012774547,-0.04916586,0.01753957,0.108903036,-0.05127663,0.010815475,0.029868556,-0.002371918,0.031797044,0.015078956,0.11615096,-0.014610859,-0.024252772,-0.05317282,0.010624288,-0.03026403,0.087750494,-0.003801161,-0.060220875,-0.030050643,-0.030600786,0.057929546,0.0293431,0.0037308345,-0.026914053,-0.053347766,-0.013519163,-0.025858814,0.06930097,-0.030732652,0.027625067,0.020670801,-0.028673517,-0.06686316,0.04452194,0.0021670326,0.015671378,-0.09851704,-0.04203444,-0.010833435,-0.04677583,0.00703874,-0.009087839,0.026021348,0.02053568,-0.036053084,0.020072652,0.021674685,0.0077433884,-0.010048504,-0.03905948,0.07622348,-0.0065306607,0.01361681,0.004577274,-0.0026295213,-0.017903632,0.03264451,-0.029837929,0.03498301,0.018358106,0.0010849872,-0.10857753,-0.008065384,0.029891552,0.06935161,0.009975831,0.03757392,0.04921284,0.14029795,0.032825366,-0.07664666,0.004737073,-0.03955706,0.02031997,0.14639111,-0.03910547,0.04097366,0.025275065,-0.040232215,0.023555066,-0.045920826,-0.011660162,0.14361207,-0.00321861,-0.0073743775,-0.068452775,0.06396948,0.027858028,-0.040553708,-0.011440291,0.023151943,0.020067137,-0.05447267,-0.15478726,2.9634562e-33,0.04802076,0.0011675996,-0.0044070124,0.009641154,0.01788403,-0.0487696,-0.07542483,-0.03248406,0.022815255,-0.018085,-0.12342668,-0.024583038,0.050265472,-0.04308736,-0.09477209,-0.052073456,-0.09341556,-0.088746145,0.04939583,0.0030665519,0.10661049,0.07730473,0.025944378,-0.04714365,0.07793125,0.016378984,-0.034999,-0.0077750566,0.03184946,-0.0038633826,0.12540922,-0.08216254,-0.10635732,0.027130855,0.06357053,0.029926607,-0.055368416,-0.04802402,0.023067458,0.04090722,-0.10381204,0.041579194,-0.018261021,0.008470313,0.066386625,-0.05262629,-0.03491974,0.041504506,0.031602953,0.049193513,0.04381372,-0.09775463,0.06590293,-0.03699072,-0.066892266,-0.0039561484,0.007379134,0.04179798,-0.030000499,0.10538704,0.086702675,0.040792797,-0.04559072,0.056522485,0.030581744,0.040766787,-0.0496938,-0.03471941,0.03872476,0.023942582,-0.039105374,0.0098537905,0.057021264,-0.023949109,0.099881455,0.034864567,-0.088337146,-0.06508366,0.0062381695,-0.00033683176,-0.023306169,-0.071707815,0.034637533,0.0088941585,-0.041561794,0.031388137,-0.022409474,0.021156963,0.013080148,-0.01913971,0.067411564,-0.01810184,-0.054457054,-0.0987683,-0.006490214,-3.3200516e-33,0.054685466,-0.014013806,0.008482376,-0.09357937,-0.04643429,0.10242842,-0.010787645,-0.0466236,-0.027292445,0.04028125,0.032035198,0.012732119,0.046424,-0.038773485,0.0694374,-0.021584915,0.014178151,-0.017210508,-0.0030287774,-0.011710561,-0.03863255,0.05900229,0.0044917557,-0.026150119,0.06077087,-0.0068178847,-0.03102959,-0.0077240053,0.066906914,0.067068875,-0.06461211,-0.040138602,-0.07748584,-0.088788405,-0.052132223,0.05443352,-0.06576472,0.012519886,-0.0041522398,0.00894201,0.004943839,-0.0437319,0.012392282,0.051643267,0.039649393,0.046781734,-0.10128382,-0.0041506942,0.032120336,0.003199803,0.02363501,-0.018831724,-0.030659087,-0.0548338,0.061106123,0.046068143,0.053077105,0.038620695,0.0071129007,-0.052663706,-0.0041490523,-0.09233015,-0.0068693296,-0.0608364,0.017780088,0.07360806,0.049057256,0.0108226,0.0036358675,-0.036404528,0.06487023,-0.0005259053,0.03261543,0.017061757,-0.0150884185,-0.0396295,0.03032202,0.029377302,-0.025459437,0.0010018022,0.042194895,0.027384082,-0.0013622132,-0.09189197,0.12688588,-0.011335444,-0.014721293,0.023709845,-0.0060447482,0.006489634,0.009070731,0.026796123,0.009005944,-0.029169977,-0.07937694,-3.928745e-08,0.039052095,-0.0371611,-0.009350048,-0.054262724,0.054540545,0.054071642,-0.01029406,-0.040932782,0.013653554,0.05232292,0.04266118,0.16977268,0.06408872,0.010731451,0.046575062,0.057454914,-0.028047811,0.040533483,-0.02674678,-0.087489516,-0.031761255,-0.037600014,-0.18807016,0.09721031,0.05423066,-0.027109956,0.017120022,-0.06787135,0.029313022,-0.10063706,0.0046218485,0.03532472,0.00951894,-0.04500984,-0.11189635,0.019177401,-0.010786293,-0.030361801,-0.036861014,0.011577642,-0.02008665,-0.008895388,-0.06325416,0.010922838,0.02895815,0.074119635,-0.0040501175,0.022369787,-0.051439155,0.023347946,0.040692847,-0.044203606,0.025987927,-0.032620817,-0.06659831,0.07921523,-0.0068056462,-0.05563001,0.046673816,0.04630394,0.031157935,-0.012730738,0.09060391,-0.0005969392 +7.1.3.2,"Requires Na+ and K+. This enzyme, found in some bacteria and archaea, couples the energy from diphosphate hydrolysis to active sodium translocation across the membrane. The enzyme is electrogenic, as the Na+ transport results in generation of a positive potential in the inner side of the membrane.",384,1.0,-0.0857665,-0.030280767,0.0017170383,-0.0017343464,0.039703447,-0.012389779,0.053741366,-0.026207471,0.0048651677,0.060497716,-0.010579299,-0.095415674,0.0034672902,0.09289945,-0.06779972,-0.03940895,-0.03165392,0.020288993,-0.006301393,-0.033888187,0.10442096,-0.00066909264,-0.021103168,-0.043561615,0.034939595,0.0070574596,0.03976469,-0.03422434,0.03763973,-0.065079845,-0.09374933,-0.03761762,0.0032376251,-0.0826953,-0.002934075,0.12286577,-0.11184527,-0.023841368,-0.021411337,-0.006059502,0.032626808,-0.007891669,0.09424067,-0.020446079,-0.021975635,-0.07074849,0.05939495,-0.08590527,0.064401366,-0.002668744,-0.012133296,-0.037024174,-0.026492547,0.026527757,-0.009613313,0.043227445,-0.11970804,-0.020497859,-0.02976047,-0.013241506,0.01223945,0.02869351,0.047632407,-0.045912948,0.12389069,-0.090532914,0.041358702,0.038956866,0.018403456,-0.025173927,-0.044150315,-0.061036393,0.043228164,0.008192657,0.017005835,-0.008852741,0.03389915,-5.8949274e-05,0.030881062,-0.031396702,0.039434474,-0.006616358,-0.060168665,0.034688346,0.06265642,0.009868373,0.025712287,-0.044091538,0.0022921758,0.026405746,0.057842948,-0.0019289446,0.0035352202,-0.031665888,-0.0043767756,0.014766409,-0.052491058,0.02021688,-0.056896903,0.00030962413,0.0025616414,0.09646779,0.00040643694,0.0039180494,0.0063987854,-0.076417804,0.012751467,0.05148468,0.007983039,0.08133175,0.057857316,0.045456834,0.03280082,0.015570455,-0.020141374,0.074776515,0.008674848,-0.12949283,-0.03224406,0.021841055,-0.003042025,-0.089072645,-0.05632535,0.061424144,-0.03389797,0.085051514,-0.039590225,1.4720646e-33,0.0115700085,-0.014017981,0.023700584,-0.041079037,-0.046082135,-0.022407252,-0.0945927,-0.009458456,-0.034957293,-0.12239831,-0.085227944,-0.01986401,0.10476503,0.036804307,-0.06017854,0.010049982,-0.0021348537,-0.089596495,0.087647766,0.010979119,0.030780787,-0.004329909,-0.014514282,0.06665429,0.0013861825,0.012705502,-0.020437736,-0.056373514,0.040022958,0.0029834067,0.03299182,-0.085299134,-0.08109793,0.08857197,0.026608475,0.040707707,0.02102189,-0.011538402,0.054562766,0.058698047,-0.040938705,0.027001068,-0.02142278,0.05727001,0.076382816,-0.059757866,-0.025376378,0.101746224,0.011860186,0.06600603,0.010063709,-0.0472709,0.06360727,-0.0069864704,-0.059524495,0.049498726,-0.017520213,-0.004925338,0.02226212,0.026505947,-0.0047153444,0.054207798,-0.021111665,0.050714187,0.01758784,0.018901525,-0.037045784,-0.0670282,0.07416616,0.040183805,-0.093937695,-0.0058205114,0.032459527,0.06193079,0.008608384,-0.023591833,-0.09768578,0.013418191,0.027916573,0.0015645752,0.009934726,-0.0593032,0.05838666,0.023283526,-0.03490482,-0.061929166,-0.02212134,0.003558904,0.024210742,0.038781058,0.041608214,0.0191353,-0.04149246,0.0046833134,-0.01847306,-2.197275e-33,0.082415365,-0.04522772,-0.05883175,-0.068282254,-0.046004597,0.045028787,0.031043345,-0.08302833,-0.0048136273,-0.024070015,0.042916358,0.01621407,0.059049714,-0.017672518,0.0015009489,-0.019241521,-0.08501618,0.0800748,0.022063436,-0.026071649,-0.014589732,0.09992535,-0.0069292225,0.05438791,0.04179386,0.037834175,-0.06839666,0.07381252,-0.06038638,0.041082896,-0.039057907,0.06560692,-0.07550907,-0.027237276,-0.082059085,0.032936405,-0.036296465,0.010348143,0.011112158,0.070014514,0.017955892,0.058223348,0.060833592,0.016619693,0.019826878,0.049436893,-0.00024542544,0.013760107,-0.005910666,-0.12047718,0.088290125,0.0068698013,-0.027981084,-0.028236536,-0.0040822932,0.049500365,-0.015782155,0.058473248,0.0029621208,-0.017933512,-0.0045440667,-0.079948686,0.060362007,-0.1128985,-0.017678209,-0.0032108005,0.04198304,0.0305374,0.02753434,-0.038977303,0.025912981,0.087379076,0.0558634,-0.04361361,-0.049416438,-0.005476895,-0.039766837,0.013513159,0.060669236,-0.10665341,-0.02367385,0.10351601,-0.021018414,-0.102688424,0.043377973,0.015520513,-0.02266811,0.0406863,0.018448684,-0.021840826,-0.04482881,-0.08987667,-0.17139375,0.045399755,0.03199554,-3.7554162e-08,0.076304026,-0.018852126,-0.021499906,-0.06291309,0.034869663,0.113032006,0.023069737,-0.015154379,0.07634589,-0.017188914,0.014037379,0.066030495,-0.009461316,0.030411985,0.041847598,0.030429268,0.028882949,0.09650691,-0.10312755,-0.03333419,0.006483543,-0.020625705,-0.14062895,0.10555374,0.06785999,-0.006323114,0.07591495,0.003891516,-0.030140271,-0.0831926,-0.0314676,0.017229095,0.01708733,0.000600022,-0.042440988,0.06997081,0.015114828,0.022260224,-0.04769313,-0.016392598,-0.024361195,-0.034704022,-0.06747981,-0.042322103,-0.054534107,0.029700642,0.02274548,0.03301595,-0.0066222767,0.018715346,0.050477352,-0.085497,-0.0073815375,-0.030832179,-0.06320486,-0.027864631,-0.030361041,-0.09421763,-0.022482095,-0.012983782,0.094337806,0.020182412,0.1046508,-0.01513675 +1.7.2.9,"The enzyme, characterized from the anaerobic ammonium-oxidizing (anammox) bacterium Kuenenia stuttgartiensis, is very similar to EC 1.7.2.6, hydroxylamine dehydrogenase. Both enzymes are homotrimeric enzymes in which each subunit contains seven c-type hemes and one specialized P460-type heme that is bound to a tyrosine residue in an adjacent subunit. However, this enzyme catalyses only the 3 electron oxidation of hydroxylamine, forming nitric oxide, and is not capable of performing further oxidation to form nitrite.",384,1.0,-0.0354387,0.018425222,-0.022008829,-0.038243745,0.024094792,-0.015437154,-0.03499798,-0.018930282,0.001761825,-0.02008769,-0.055313513,-0.09950632,-0.072651245,0.0105150575,-0.06551935,0.07851667,-0.071809836,-0.09216885,0.03821566,-0.008566205,0.0463853,0.040551946,-0.016589819,0.0023085123,0.031475876,0.009399591,0.025682593,0.01614614,-0.061691158,-0.13566671,0.017891001,0.00048629806,0.06205211,0.010977354,0.07141469,0.05844799,-0.06621326,-0.084184855,-0.00016335663,0.05033029,0.020489546,0.0005118159,-0.069164105,-0.020440854,-0.024289638,0.0025678666,0.020195588,0.0034369896,0.035423,-0.027926395,-0.025167689,-0.10290896,-0.009225767,0.017160695,0.07590526,-0.013078368,-0.029175408,-0.031002173,-0.011851356,0.04362605,0.05656501,0.021569831,0.0018447341,0.003318517,0.010392756,-0.09236576,0.07220957,-0.094982475,-0.0016985168,-0.09676297,-0.048891533,-0.091992624,-0.024018517,0.04325564,-0.07668922,-0.016199965,0.01704323,-0.03351261,0.03887627,-0.03205434,-0.026579926,0.053718217,0.0124822445,0.07400163,0.04668748,-0.022062609,0.0017409407,-0.015309574,0.042407583,0.0072778664,-0.022997038,0.050817803,0.033329017,-0.03989498,-0.00383013,0.02926449,0.017329829,0.15162234,-0.0033083383,-0.0008023603,0.059183013,0.11303428,-0.086145826,-0.045349993,-0.03258969,-0.019474942,0.087692626,0.08889551,0.06665897,-0.009809063,-0.022723956,-0.055962402,0.040055994,0.012854307,0.0006369841,0.010895034,0.058299176,-0.019302992,-0.039321966,0.032295305,0.037204057,-0.072375745,0.040906116,0.01180274,-0.029970875,0.088813506,-0.10803468,4.0898167e-33,0.080174334,-0.0070171887,-0.023370296,-0.010006661,-0.051373854,0.011390053,-0.11056691,0.027102053,-0.0077267713,-0.074532986,-0.08429526,-0.0011308156,0.035924204,-0.018285137,-0.011285297,-0.012572821,-0.047982387,0.0031053657,0.032081235,0.07388878,0.019364158,0.019405019,-0.069393195,-0.012277422,-0.00888154,0.015935093,0.02399846,-0.041896246,0.02565803,-0.008368428,0.06767757,-0.07232451,-0.07189686,0.016521182,-0.057859402,-0.028550224,-0.009929299,0.044454236,-0.054223724,0.029148467,-0.08851065,0.08279551,0.03556098,-0.08007771,0.044280566,0.009680671,-0.03697405,0.07935826,0.1027457,0.026365343,0.0005828545,0.026357133,0.12887517,-0.086694255,0.024267105,0.09185019,0.05328052,0.031012706,0.0929244,0.06022994,0.009510931,0.05776284,-0.042966135,0.013206038,0.046254814,0.031471685,0.0052512176,0.011055384,0.034879833,0.046747323,-0.10628072,0.030751202,0.117204286,0.03302466,-0.02723201,-0.05150718,-0.0606599,-0.02063246,-0.0070101516,-0.02681516,0.06719283,-0.03786297,0.092219725,-0.04248952,0.014828169,-0.02931901,-0.005445607,0.03250436,0.009837832,0.052310552,0.08665571,-0.089494206,-0.076574355,-0.06464892,-0.019673029,-3.4209975e-33,0.114049174,-0.032898407,-0.08066108,-0.09349022,0.0077124517,0.08771306,0.018259251,0.042847477,-0.031781618,0.012856846,0.118604764,0.008700263,0.04827131,-0.042625953,0.08844473,-0.05015122,-0.042847425,0.04872263,-0.057966713,-0.023474272,-0.010608456,0.06101094,-0.039207198,-0.015834237,0.026341647,0.051589362,-0.046581317,0.0429999,0.0639174,-0.0414562,-0.058557436,0.019073969,-0.02629402,-0.049980596,0.030976618,0.010244086,-0.064650536,0.0048826556,0.03073735,0.0240341,-0.023291305,0.05394333,0.05022668,-0.008012235,0.008128386,0.075608075,-0.08354798,-0.029433884,0.003858258,-0.04586874,0.0062918253,-0.0052660466,-0.030909708,-0.0019912417,0.018729057,-0.029215135,-0.018864127,0.05105337,-0.0033163878,0.01092361,-0.005970379,-0.03233859,0.087100424,0.0016662749,-0.07068566,-0.00087884784,-0.0840461,0.077452555,-0.0348354,0.022229098,-0.010804595,0.00019880987,0.041216042,-0.0025147507,-0.02623468,-0.0609144,-0.011529012,0.007831473,0.008702675,-0.024673682,0.060481198,0.011649372,-0.0031542943,-0.042415496,0.022705272,-0.010509312,0.040686656,0.039970182,0.0037343139,0.025363319,0.0051435735,-0.007754825,-0.09001002,0.058504082,0.01092022,-4.194787e-08,0.017794054,-0.097999014,0.11184631,0.009806863,0.036951084,0.035617646,0.0038853495,0.020552933,0.087480895,-0.030610742,0.08279138,0.08572435,0.01681248,-0.0320768,-0.0005047633,-0.014378832,-0.035912167,-0.011047206,0.005142993,0.07080012,-0.04892992,-0.0012511056,-0.10137296,0.07630755,0.022008324,-0.038107987,-0.034959055,0.004294122,0.021121688,-0.058502875,-0.07728834,0.09539937,0.01696251,-0.0154182995,-0.098286554,-0.036353845,0.0008546438,0.033703525,-0.04804221,-0.03274423,0.01837266,-0.122085154,-0.06387514,-0.016074888,0.08110596,0.016867066,0.0026600384,-0.053675525,-0.024933068,-0.03045658,0.03931135,-0.020204961,0.0226656,0.008399637,-0.09147289,0.029460957,-0.03200302,-0.06365713,-0.020941857,-0.030201042,0.0498014,-0.007667992,0.2135439,-0.0007571608 +1.14.13.248,"The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites. Requires an FAD cofactor.",384,0.99999994,-0.10561215,-0.062306527,-0.09834774,0.008336163,0.026986638,0.058303256,0.011434292,0.07165191,0.040588632,-0.01132404,-0.01574468,-0.061679296,-0.03584578,0.09352458,-0.07362364,0.031132743,-0.07501057,-0.051608577,0.015299984,-0.035946716,0.06066082,0.10538499,-0.0043696403,-0.011896702,-0.01680433,-0.027052077,0.0085556265,-0.031759698,0.034621455,-0.059109874,0.037954222,0.0793273,0.009193455,-0.07248468,0.069367684,0.04423444,0.013906382,-0.031041725,0.038853694,0.037774596,0.033278797,0.029970411,0.004976607,0.027187577,0.021692015,0.022060305,0.03659696,0.038306672,0.0349987,-0.046397276,-0.072588876,-0.052805025,0.0034738055,0.059377782,0.05368839,0.023733241,-0.013309303,-0.09126196,-0.04111392,0.009204284,0.0788187,0.014192946,-0.017733669,-0.019740086,0.0564603,0.027610032,0.0038462032,-0.060266256,0.047388405,-0.07156116,-0.02625212,-0.068563126,-0.057354078,0.024416573,-0.0063577774,0.0059211883,0.017130196,-0.026525212,-0.0010594494,-0.017289856,0.015926758,0.06628022,0.080337025,0.066422775,0.05399173,0.0019799091,0.03990779,0.011849821,-0.00034339828,0.0673618,-0.0058688433,-0.014824113,-0.0014031524,-0.061712768,-0.07780725,-0.009121212,-0.021262785,0.0001834763,0.028996322,0.0060347077,0.022303766,0.04554909,-0.021949738,-0.0032309603,-0.08008345,-0.022470953,0.023688745,0.08681845,0.042753022,0.05345777,-0.0052648094,0.022125965,0.022948917,-0.025033357,-0.01989098,0.027382428,0.039297905,-0.05047905,-0.060757056,0.027995976,-0.0131327985,-0.024005704,-0.03184135,0.036461666,-0.01821602,0.06452328,-0.14162576,4.2865986e-34,0.097771734,0.02732174,-0.038210083,0.011658723,0.019497307,0.005591756,-0.13579975,-0.048174895,0.022706363,-0.10834377,-0.069732785,-0.04179393,-0.018523367,0.0011194538,0.018839879,0.025338199,-0.08011598,-0.039989807,0.09338035,-0.01605636,0.03537805,0.088820346,-0.07044098,-0.026682379,-0.015869854,0.10076382,-0.044555187,0.024336683,-0.007096793,-0.020093938,0.022152131,-0.09706573,-0.07517821,0.04777104,0.043157462,0.008021983,-0.019138772,-0.042555254,-0.015094692,0.07458657,0.011684732,0.08593776,0.0042045102,0.004987609,0.038743418,-0.0817712,-0.07738117,0.13528372,0.09307588,0.064264484,0.023386344,-0.04201203,0.107523836,-0.006331234,-0.069244996,0.0366605,-0.029140532,-0.019713623,0.08102467,-0.015469929,0.051540393,0.008114355,-0.0052227667,0.16761045,-0.004002753,-0.0055942605,-0.054820985,-0.04545251,0.06260297,0.13121174,-0.13607429,-0.007678097,0.031241434,-0.002153955,0.04013223,-0.1376678,-0.030311324,-0.055591073,0.036446925,0.0385542,0.024152324,-0.09848821,-0.0048292195,-0.03357437,-0.035666626,-0.0052074576,-0.018305466,-0.07308931,-0.016581917,0.016676957,0.008475866,-0.09923575,-0.08707774,0.049764503,0.0356012,-1.7495784e-33,0.109788865,-0.10507645,0.07857104,-0.053010415,-0.0138117485,0.053503975,-0.018844778,-0.101095945,0.028476182,-0.00064802606,0.03394206,-0.0017840413,0.05897374,0.018470049,0.04664205,-0.02951658,0.046386696,0.0020142198,0.012789659,-0.0028807423,-0.062294636,0.038502514,-0.03240885,-0.047884557,0.021462753,0.0007562813,-0.072296865,0.0060126907,0.0074920272,0.0251951,-0.0100306505,-0.016820384,-0.07097499,-0.1170525,-0.061179228,0.037451856,-0.004477541,0.020730555,-0.03681391,-0.065553196,0.045898084,0.043544434,0.07452797,0.12062444,-0.0014889842,0.07556492,-0.094987914,-0.030988162,0.025381958,-0.021023234,0.04081192,0.00023157655,-0.036568332,-0.023641896,0.003906501,0.01359585,0.042862155,-0.0023546794,-0.05315773,0.014747014,0.0020259984,-0.04255598,-0.03186395,-0.047585346,0.04591213,0.026562955,-0.004512398,0.0997071,0.06513396,0.020980608,0.045518294,0.056550223,0.05725005,0.0439651,-0.055830292,0.0007382073,-0.08458039,-0.038535226,0.030174697,-0.010842138,0.016707903,-0.033676494,-0.030157618,-0.02109688,-0.057196327,-0.06195319,0.062579714,0.116864786,0.014000373,0.01386116,-0.01228022,0.033242427,-0.015273259,0.013312823,-0.03830531,-3.5167503e-08,0.018628437,-0.07724046,0.018906947,-0.009948051,-0.017805459,0.023877982,0.014741913,-0.034597293,0.06262252,-0.02833872,0.014191223,0.07514695,-0.018529892,-0.01177913,0.07063043,0.01288835,-0.026269134,0.0029306007,-0.04284711,0.01175207,-0.09899501,0.016472824,-0.067447044,0.03745993,-0.008276273,-0.06643445,0.029393101,0.05302165,-0.010458366,0.017140169,-0.010839118,0.03237572,-0.00798178,-0.019510746,-0.11609006,0.03195483,0.009085962,-0.04485439,-0.016950766,-0.031211106,0.021397682,-0.018481316,-0.076881185,-0.0069994004,-0.042465597,0.0070052766,-0.071536385,-0.036053453,-0.020097353,0.009595448,0.03449802,-0.041539397,0.012356483,0.019879604,-0.08421026,0.053821675,0.06722898,-0.08690411,-0.003323679,-0.06028891,0.015219488,0.036162417,0.1537304,0.010100024 +1.14.13.249,"Requires FAD. The CreL enzyme from the bacterium Streptomyces cremeus participates in the biosynthesis of cremeomycin. The PrmB3 and PtnB3 enzymes from Streptomyces platensis are involved in the biosynthesis of platensimycin and platencin, respectively.",384,1.0,-0.07635687,-0.021772787,-0.13208044,-0.07160154,-0.01759323,0.0603426,-0.038504094,0.046291627,0.086314954,-0.03226875,-0.003284324,-0.087124266,-0.0034309013,0.022265363,0.0008998402,-0.053400308,-0.104264736,-0.007841062,0.044129584,-0.07778592,0.0752502,0.094230756,0.03701261,-0.03155146,0.020637484,-0.001223685,0.01847178,-0.0067231935,-0.0078037484,-0.013791189,0.070539914,0.0009660922,0.041626755,-0.08296171,0.11773482,0.08795488,0.031538956,-0.028653298,0.11674787,0.029616008,-0.025177948,0.01792292,-0.0122143,0.019554332,-0.007355118,0.020000907,0.05021226,0.0689929,-0.045537233,-0.033224035,-0.02866788,-0.0385139,-0.017011413,0.05682871,0.065142535,0.08412602,-0.032134283,-0.04670515,0.015000525,-0.034647666,-0.036418993,-0.063003846,-0.0024924723,-0.009998407,-0.036273044,-0.05972574,0.0037894542,-0.09112733,0.032260068,-0.004296187,-0.07685091,-0.011029564,-0.045273963,0.02271825,0.015283962,0.041184705,-0.0020715853,-0.032309372,-0.07881158,-0.05426563,-0.0020554706,-0.023457995,0.049347006,0.10370314,0.06736058,-0.029389288,0.025589855,-0.043765254,-0.002102373,0.07423833,0.083446436,-0.019422276,0.006137554,-0.08076336,-0.05759412,0.024864126,-0.076427914,-0.03498623,0.06134299,-0.0067786127,-0.04099809,0.017252518,-0.0009804018,0.02998159,-0.023566045,0.033545878,-0.0695136,0.085314184,0.018891716,-0.024306232,0.00059578335,0.015914366,0.0018010201,-0.06638897,-0.019679671,0.010180931,0.0098679885,-0.08979032,0.028549073,-0.05386849,-0.026582628,0.020252414,-0.05232041,0.07859402,-0.010965774,0.0100904135,-0.09426402,4.617446e-33,-0.0055000954,0.07727191,-0.0098644225,-0.056414913,-0.01746744,-0.0051268674,-0.1252019,0.014867463,0.010597728,-0.08918323,-0.02011908,-0.0691421,0.022032594,0.004560758,-0.0016684538,-0.008146276,-0.029362135,0.03144296,0.027512798,0.020464608,0.040769044,0.053500872,-0.010584888,0.0065032723,0.0056203147,0.051359683,-0.0017428023,0.03900587,0.060556673,-0.041248854,0.039022185,-0.07494378,0.031660516,-0.00573378,0.005653244,0.0020556948,-0.023672825,-0.071742825,-0.02402407,0.07495889,0.028886696,0.0037676408,-0.034327604,0.010523682,0.055946182,-0.06000527,0.019669013,0.037599936,0.03513762,0.07555297,0.057677966,0.03728128,0.16692892,0.009263313,-0.0648127,0.025695877,-0.030945357,0.015030846,0.07505304,-0.014086424,0.009419442,0.024732478,0.031161027,0.04765567,0.033998813,0.05313024,0.0020134836,-0.052510954,-0.0032744957,0.0921102,-0.08137549,0.028688278,0.0031196282,-0.0014233766,0.073534906,0.012714524,-0.064851716,-0.019460678,-0.013602989,-0.00952289,-0.07788709,-0.026420278,0.004479887,-0.06574474,-0.018346202,-0.031092066,-0.04952339,-0.108416766,0.028902745,0.044506576,0.009850396,-0.09696317,-0.0715182,0.12705359,0.018562825,-4.901601e-33,0.07496119,-0.05376267,0.08117652,-0.05162662,-0.085014395,0.089798965,-0.048628397,-0.028276037,-0.014890626,-0.07435811,0.03259079,-0.02416227,-0.029359393,-0.075715706,0.012243968,0.0015457168,0.029541614,0.09581154,-0.0342602,0.03851735,0.017225394,0.117829576,0.032331735,0.06584382,0.02219294,0.043431535,0.004853193,0.05995757,0.033505585,0.0012981803,-0.00018636507,-0.03196461,-0.032169007,-0.024244547,-0.09158239,0.06335005,-0.07079406,0.09155837,0.08397075,0.04953322,0.122148365,0.044911403,-0.013252878,0.079423524,-0.055284973,0.035954583,-0.04417316,0.06512722,0.0108759515,-0.034948133,-0.041759398,0.022034183,0.015286249,-0.06717297,0.06506308,0.017268777,0.02051921,-0.006094628,0.011948083,-0.022614209,-0.035418853,-0.038696796,0.07991561,0.048096687,0.09974606,0.010578461,-0.030280247,0.070044346,0.0877598,0.056299295,0.025067087,0.076164074,-0.033859115,0.032534145,-0.004321102,0.049991544,-0.10993543,-0.070613876,-0.009351905,0.0441625,-0.019768192,-0.019482931,0.01729683,-0.041091554,-0.051307946,-0.008082112,0.013039413,-0.015258432,0.026393909,0.023084873,0.0032826513,0.042859167,0.0817681,0.010927585,0.045866545,-3.2398525e-08,0.075474046,-0.026152322,0.05874093,-0.00802407,0.0048034764,-0.05462394,-0.024186,-0.054420933,-0.022727568,-0.016643498,-0.07784482,-0.006696321,0.020467373,-0.06573788,-0.013760711,0.046489004,-0.08439762,-0.055536047,-0.02849793,-0.04091616,-0.0861143,0.013173873,-0.0456454,0.08560979,0.048924472,-0.043380078,0.031623982,0.019035442,0.0027592054,0.040511806,0.020973543,-0.042399433,-0.052774813,-0.025590315,-0.042302348,-0.0012006643,-0.03319327,-0.076332815,-0.026797878,-0.015278169,0.06226259,-0.031410564,-0.08497309,0.010311477,-0.10548203,0.03388398,-0.0412802,-0.006769076,-0.06355697,-0.037337374,0.062474072,0.004116156,-0.036623493,0.011098589,-0.12631832,0.027247442,-0.01131782,-0.055042744,-0.026815303,-0.0076926267,0.016160088,0.033576444,0.16458349,-0.06367657 +1.14.13.250,"The enzyme, characterized from the bacterium Streptomyces achromogenes subsp. streptozoticus, catalyses a complex multi-step reaction during the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin. The overall reaction is an oxidative rearrangement of the guanidine group of Nomega-methyl-L-arginine, generating an N-nitrosourea product. The enzyme hydroxylates its substrate at the Ndelta position, followed by a second hydroxylation at the Nomega' position. It then catalyses an oxidative rearrangement to form Ndelta-hydroxy-Nomega-methyl-Nomega-nitroso-L-citrulline. This product is unstable, and degrades non-enzymically into nitric oxide and the denitrosated product Ndelta-hydroxy-Nomega-methyl-L-citrulline. The enzyme contains two active sites, each of which utilizes a different iron-containing cofactor.",384,1.0,-0.05307005,-0.058355,-0.14662261,-0.008103666,0.03774815,0.0355842,-0.031704478,0.031696957,0.05660245,-0.065056615,0.0075706304,0.007900495,-0.019326426,0.028915713,-0.07590123,0.014328641,-0.01786393,-0.059907164,0.022174664,-0.022778897,0.119283624,0.06809562,-0.02949449,-0.0781862,0.0050659496,-0.014965492,-0.021004407,-0.06376742,-0.0003696836,-0.12518474,0.038578063,-0.039361,0.02010118,-0.032027844,0.11158719,0.037601225,-0.05495151,-0.05084234,0.022922046,0.024263633,-0.010652911,0.031695563,-0.04460636,0.012872423,-0.025392547,-0.0033961486,0.053458527,0.08959567,-0.019172033,-0.0040783496,-0.06173594,-0.09780367,-0.02663688,0.0694559,0.08088666,0.030525913,-0.07419687,-0.08883025,0.0071768495,0.02841524,0.122773,0.0014257313,0.0063290535,-0.05990607,-0.020106846,-0.015345572,0.091029346,-0.11532923,0.0031502978,-0.0243725,-0.04841433,-0.011137193,0.015405372,-0.008919511,-0.030408265,0.03240955,0.0025329879,-0.0051005883,0.014818567,0.0029948298,0.0028647871,0.07645949,0.0065478417,0.06737215,0.071094655,-0.01735008,-0.04393907,0.031042825,0.12698442,0.019878361,-0.0148155065,0.006953701,-0.011546287,-0.034216568,-0.034794934,-0.023078414,-0.06311629,0.039783902,0.015443577,0.0043703,0.02293735,0.048941873,0.03582799,-0.052866757,-0.06344636,0.03128833,-0.0037388294,0.085955046,0.062346216,0.041322645,-0.055361096,0.061962623,-0.017961757,0.053547025,-0.05332257,0.05174024,0.06866044,-0.047446832,-0.10718786,0.0047747097,0.06300187,0.00399275,0.0023632278,0.024562707,-0.04575206,0.08694481,-0.09031854,4.8119625e-33,0.018043986,0.07419209,0.00037461,-0.031397767,0.07181743,0.0116672525,-0.10847199,0.009544138,0.02500741,0.01851094,-0.045415405,-0.020460518,0.011007247,0.008794536,-0.019856988,-0.014176562,-0.023965692,0.065162405,0.06575681,0.053920973,0.04889114,0.06937916,-0.07810968,-0.015932633,-0.037104696,0.06326322,-0.016412478,0.0049862014,0.023532711,-0.042244416,0.008053818,-0.10379544,-0.051959317,-0.0401034,0.11008697,-0.082361594,-0.016731631,-0.024500707,0.04619934,0.05165524,-0.037520826,0.07000129,-0.024752177,-0.010222065,0.060889773,-0.065363005,-0.084623724,0.07372601,0.050584916,0.038380522,0.030183934,-0.033592723,0.07802476,-0.010296811,-0.07829516,0.016936222,-0.05233174,0.017957324,0.080880806,-0.026382081,-0.0045220125,-0.039420653,0.015064625,-0.08915234,0.066699706,-0.0050439844,-0.041293334,0.018162081,0.054001052,0.059853945,-0.076533414,0.007925045,0.014170483,0.06565943,-0.0013909335,-0.09475899,-0.0871549,0.050038002,0.09279218,0.022702187,0.032576796,0.08194163,-0.01889308,-0.09235014,-0.034910016,0.0061019673,-0.026865756,-0.04454639,-0.0036165414,-0.022031995,0.039746154,-0.051541287,-0.053025674,-0.05390176,0.036676727,-4.45984e-33,0.08705836,-0.097464345,0.032557186,-0.067229286,-0.0001546534,0.027531752,-0.019239403,-0.027469223,-0.00664352,-0.052372474,0.059077114,-0.01022645,0.02447218,-0.007651658,0.06560666,-0.0259932,0.034646954,0.092444785,-0.045831986,-0.028573146,0.010151776,0.03310292,-0.03561365,-0.019182242,0.036782965,0.057124216,-0.012187669,0.060075924,0.08878416,0.08150398,0.0065767,-0.023916995,-0.058112554,-0.088700175,0.023960188,0.050423026,-0.059138585,0.06084299,0.057731718,-0.061131813,0.1192505,0.04438443,0.06228027,0.07603343,0.012432481,0.07354462,-0.13921316,-0.022221433,-0.030128345,-0.028786361,0.040694095,0.032746684,-0.06445764,-0.026529059,0.03706887,0.034529883,0.052530617,-0.02503167,-0.009403862,-0.0033710983,-0.042010356,-0.013985607,0.014624296,-0.03657026,0.01687653,0.012149268,-0.0064139497,0.0893504,0.058649715,0.0067535704,-0.05404448,0.034196846,0.020417577,-0.010548164,-0.04076929,-0.0009136563,-0.042401616,-0.046792805,0.0009809294,-0.07991129,-0.0180312,-0.047034774,-0.019519094,-0.061665982,0.010322934,-0.02365252,0.06903395,0.08631726,0.056368515,0.026573958,-0.033125095,-0.046104833,-0.04529353,0.037050903,0.010605989,-4.6968275e-08,0.009820964,-0.06385607,0.06511369,-0.00038132071,0.0006534112,0.009715093,-0.040684372,-0.055681016,0.060689073,-0.056642614,0.072690025,0.07175147,0.0048864144,-0.06067578,-0.04007978,0.034452025,-0.03756077,-0.016295742,0.013585329,0.0076279887,-0.08550791,0.034375254,-0.1013925,0.052547198,0.040762857,-0.05881186,0.025006706,0.008296913,0.02137842,-0.034132417,-0.006762516,0.0784833,0.016476037,-0.020410795,-0.04411792,-0.05600861,0.018194,0.00090591883,0.04037696,-0.060273,0.021612795,0.05494373,-0.069322474,0.017720724,-0.032946624,0.015094817,-0.02399838,-0.055889692,-0.06683783,0.064484894,0.04840556,-0.024423841,-0.011634759,0.010765899,-0.12748475,0.017656064,-0.007886856,-0.052931476,-0.030723725,-0.011158592,-0.03125867,-0.048126865,0.16787204,0.012394249 +1.16.3.4,"The enzyme, characterized from the bacterium Escherichia coli, is involved in copper tolerance under aerobic conditions. The enzyme contains a substrate binding (type 1) copper site and a trinuclear copper center (consisting of type 2 and type 3 copper sites) in which oxygen binding and reduction takes place. It also contains a methionine rich region that can bind additional copper ions. In vitro, if the substrate binding site is occupied by copper(II), the enzyme can function as a laccase-type quinol oxidase (EC 1.10.3.2). However, in vivo this site is occupied by a copper(I) ion and the enzyme functions as a cuprous oxidase.",384,1.0,-0.05329134,-0.06936249,-0.013214775,0.021763798,0.09754656,-0.037478063,0.008634914,0.05876267,0.03000801,-0.06818532,0.035156764,-0.06890289,-0.041878376,0.022651693,-0.077142976,-0.05848242,-0.013375997,-0.002367137,-0.019965736,-0.021580884,0.05563362,0.0015078082,-0.02743523,-0.029486394,-0.08854565,0.036205806,0.047120128,-0.0017813158,-0.020329976,-0.0426182,-0.0409014,-0.03379766,0.016913308,0.022677861,0.0042702947,0.06157668,-0.025787773,-0.047332197,0.0334503,-0.024450945,0.06115103,0.056072332,0.10614097,0.023338227,0.09122157,-0.052444726,0.08183051,0.007955133,-0.006015031,-0.019636337,0.012523116,-0.048929017,-0.0027376346,0.04608695,0.06950624,0.038033728,0.006305662,-0.08268055,-0.020951387,-0.0077007883,0.09411295,-0.025614634,-0.012625927,0.025709754,0.034682374,-0.063182496,0.03576177,-0.026826859,0.011814343,-0.044048138,-0.051675834,-0.00942182,-0.07658547,0.0051805945,0.0046478617,0.07915746,0.113600835,-0.09866859,0.076605156,0.001954044,-0.035439514,0.016383506,0.031368427,0.04570824,0.069746956,0.00752954,0.07257036,-0.019863216,-0.008162824,-0.062716365,0.018587573,0.054462407,-0.048594344,-0.06952071,-0.06971668,0.02779886,0.004314072,0.027677275,-0.03310792,-0.028407708,0.034814578,0.06908362,0.027465198,-0.06511198,-0.064171895,0.015103507,-0.019757897,0.092015944,0.009594163,0.042662855,0.007610224,0.00070799387,0.04026581,0.034198124,0.038925856,0.06884884,0.019650567,-0.059798323,-0.05750044,0.00089753565,-0.01798665,-0.051162742,0.018593837,-0.024966942,-0.00055081473,-0.04788859,-0.012488152,1.5078768e-33,0.02071492,-0.025058378,-0.041395113,-0.03905123,0.12668204,0.0019055484,-0.052320376,0.0028137793,-0.10206502,0.044606473,-0.06770983,-0.060528334,0.03446088,0.024097905,-0.022907097,-0.008908086,-0.036394767,-0.007667449,0.011487923,0.010857212,0.057848956,0.000967747,-0.022183353,0.02760794,0.06702047,-0.010885367,-0.018877126,0.02232786,0.013341954,-0.022314379,0.017270612,-0.039821237,-0.01601745,0.0027305174,0.04676098,-0.0041487045,0.035951063,0.034986243,0.011387998,0.063533336,0.00818212,0.049231283,0.021648938,0.025985627,0.043299474,-0.09379975,-0.042796616,0.14300857,-0.01758667,0.005304739,0.04185749,-0.051164344,0.092315376,-0.012204237,-0.041945666,-0.0045549977,-0.095853955,0.011143525,0.074898556,0.009339472,0.02673121,0.00787429,-0.07681925,0.065394044,-0.013798621,0.07164863,-0.022956952,-0.050563194,0.06445219,0.1374801,-0.06723338,-0.034775786,-0.031236524,-0.006546712,0.0074859275,-0.049787708,-0.093418516,-0.0114485305,0.07039322,0.04418561,-0.04250758,0.005601138,0.035723962,-0.004118967,-0.07800061,-0.10359025,-0.04122697,0.030008398,0.03003658,-0.04554621,0.08579974,-0.0058639687,-0.024293259,-0.030952016,0.01756275,-1.430339e-33,0.04800114,-0.067911915,0.013005519,-0.08618897,-0.04971289,0.009571791,-0.025432486,-0.02171651,0.06438778,-0.07865417,0.101617664,-0.013536343,0.0029504197,-0.015704453,0.01649548,0.032799903,-0.10386689,0.10717654,-0.022863315,0.0059371935,-0.009133351,-0.012995578,-0.013439219,-0.042139698,0.039639074,0.02878245,-0.12512134,0.037660807,0.049763735,0.021615226,-0.05286771,0.019754563,-0.029605092,-0.009950737,-0.07434406,0.032218847,-0.0067636804,0.008912402,0.050831143,0.08289433,0.07320755,0.04016765,-0.0033141978,0.10914427,0.010241787,0.09389951,-0.079911806,-0.02917655,-0.057015736,-0.022716356,0.04129397,-0.026719628,-0.01439906,0.027709618,0.07307317,0.12748212,0.0006683026,-0.03302857,-0.031623732,-0.0016855574,-0.0573068,-0.09046152,0.0029114357,0.018139297,-0.0023720677,0.029224634,-0.03651165,0.13658264,0.008640082,-0.03085886,0.035681702,0.07907098,0.038566615,-0.047583353,-0.060044747,-0.05060849,-0.0442507,0.059608057,0.044341143,0.061111677,-0.023935672,0.067296654,-0.0021789945,-0.056254677,0.012664244,-0.011663313,-0.02418552,0.12759684,0.028138954,0.0064146034,-0.08249421,-0.07858926,-0.02165298,0.03372328,0.051215496,-3.7324227e-08,-0.045400936,-0.042361297,0.039675813,-0.05408096,-0.033404704,0.09791903,0.06479367,-0.009605836,0.062282313,0.02379072,-0.008051765,0.1128972,-0.04107909,-0.061743017,0.01962113,0.10341117,-0.013198372,-0.053505816,-0.012863527,0.009921828,-0.017385494,-0.02852737,-0.08918766,0.026845781,0.0055848984,-0.04343406,0.013066015,0.06525491,-0.19003743,0.008596299,-0.04914782,0.020430094,-0.009076536,0.00035467616,-0.056521323,0.016266594,0.0010476457,-0.002374389,-0.045402367,-0.0236538,-0.011563919,-0.107191406,-0.07764704,-0.023693731,0.06592185,-0.006589155,0.013660943,0.046408422,0.031255815,-0.045406017,-0.011493961,-0.022662567,0.030912235,-0.022235386,-0.05141576,0.049386453,0.010891088,-0.05345007,-0.064082764,-0.0128344875,0.046738673,-0.0007077491,0.17156117,-0.05475341 +2.1.1.380,"The enzyme, characterized from the bacterium Streptomyces cremeus, is involved in cremeomycin biosynthesis.",384,1.0,-0.034956098,-0.009144861,-0.1358486,-0.010591384,-0.015874092,0.0382171,-0.0706194,0.066646636,0.07701866,-0.047092404,-0.0072236666,-0.05165744,0.05076458,0.03591047,-0.054339122,-0.009508229,-0.06782991,-0.008834426,0.04293952,-0.07606178,0.11179861,0.09749011,0.017211584,-0.0012913597,0.06332782,-0.009804462,0.025960037,0.013523697,-0.03527012,-0.007678144,0.032721158,-0.030242188,0.061922427,-0.06512598,0.116194576,0.10819246,-0.029975034,-0.033260472,0.15397927,0.022676894,-0.03552459,0.009881345,-0.021772174,0.04304182,-0.026990242,0.0076028523,0.031279277,0.078655235,-0.0195847,0.020186374,-0.049670156,-0.073436,-0.08211769,0.075320534,0.05301742,0.06888063,-0.017458003,-0.01716648,-0.0031284264,-0.041375153,0.036422305,-0.04079347,0.04372995,0.009886395,-0.08590582,-0.07435759,0.022734046,-0.1012042,0.039197262,-0.03383166,-0.08681258,-0.04931567,-0.015309959,0.032111548,0.0059275692,0.008104561,-0.032659806,0.013469327,-0.054578204,-0.0072067776,0.046428137,-0.06637754,0.0120178405,0.07543682,0.06918982,0.0072303447,0.07725971,-0.021466143,0.07653756,0.045826677,0.007731751,-0.04154785,0.0038449338,-0.08978408,-0.039096113,-0.01694204,-0.08556595,0.012346648,0.047025017,-0.027563972,-0.024867699,0.017287726,0.032846283,-0.014298163,-0.034249626,0.021294557,-0.05239154,0.0658354,0.018373352,-0.044878494,-0.0145389475,0.020885669,0.012700822,-0.034180187,0.02906263,0.07125976,0.06870003,-0.038531817,-0.040559977,0.008461059,0.013686356,0.0034890124,-0.0039056514,0.031514864,-0.020513395,0.033274215,-0.107777536,3.762691e-34,-0.005561863,0.08755322,-0.0016071337,-0.07024671,-0.0003657115,-0.010636536,-0.14063609,0.042387754,-0.025374232,-0.06850971,-0.056921616,-0.052110545,0.020306196,0.01789773,0.022135895,-0.007494725,0.0021768655,0.055521052,0.035682105,-0.00057449786,-0.002417504,0.035435352,-0.045350447,0.0030129428,0.007671385,0.031029731,-0.0021284942,0.037199855,0.09665633,-0.05852916,0.017360216,-0.062954575,0.005135276,-0.023598444,0.07207315,-0.0027708097,-0.004527164,-0.061188098,0.0123549355,0.039485883,-0.007819115,-0.009007365,0.009214121,-0.009012986,0.03857001,-0.046940852,-0.03300848,0.021327239,0.073142156,0.049750507,0.020654198,0.009585739,0.19123867,-0.012545138,-0.07527424,0.0195513,-0.012108645,0.023993332,0.026174301,0.016236532,-0.022546513,0.0041099265,0.031456444,0.02067912,0.038061727,0.021646837,-0.020761909,-0.012381264,0.02293087,0.075360075,-0.07400587,0.029899254,0.0064622974,-0.009735368,0.050368086,-0.011469296,-0.06620273,-0.008154836,0.026728218,0.0048055765,-0.06419608,-0.03430748,0.009772588,-0.0908332,-0.020804875,-0.011837532,-0.07964111,-0.06557857,0.013845839,0.042897873,-0.025667692,-0.08825255,-0.084837936,0.10337242,-0.0013316268,-2.4211415e-33,0.056503102,-0.077197894,0.064590566,0.019572947,-0.04705769,0.09309541,-0.059566647,-0.012999257,-0.03448795,-0.06440271,0.037163332,-0.019842733,-0.031428177,-0.05390826,0.00798056,0.00973135,0.010803526,0.08359316,-0.009813164,0.028584102,0.03210265,0.08091621,0.018526124,-0.02824659,0.005569366,0.0463374,0.028087303,0.04657091,0.02560221,0.057817496,0.005595425,-0.07751695,-0.016756395,-0.03441694,-0.06913393,0.09084454,-0.052450456,0.037405603,0.08699538,0.016499916,0.11599006,0.0264567,-0.011303048,0.08892642,-0.016298117,0.026768854,-0.05196096,0.109128706,0.022316458,-0.06507093,-0.0074158115,0.042857382,-0.0016578804,-0.039576743,0.016954582,0.041283038,-0.029258322,-0.015182678,-0.048622914,-0.0054353904,-0.04591681,-0.064353615,0.023050027,0.01229539,0.076768644,0.022323772,-0.060359076,0.05155968,0.060111072,-0.011165892,0.012227226,-0.006956456,-0.037623953,0.072630055,0.0067184228,-0.020531785,-0.08570106,-0.10655102,-0.020765524,0.027641362,-0.028499644,-0.030146904,0.026244428,-0.04943966,-0.04009088,-0.056550104,-0.024989879,-0.0068954467,0.039251275,0.03668581,-0.0025783025,0.057660047,0.03998718,0.011152289,0.04049177,-2.4874293e-08,0.085627645,-0.017180737,0.116570696,-0.019941699,0.05377565,-0.052950572,-0.033903513,-0.041060925,0.005396753,0.0017698205,-0.11062909,-0.011813225,-0.015069465,-0.017606625,-0.0034365966,0.045888018,-0.10478341,0.005400573,0.0017307383,-0.011052384,-0.073146075,-0.031359892,-0.074315764,0.061118998,0.06302509,-0.08243882,0.008120231,0.060412556,-0.05282413,0.042714678,0.01454186,-0.014959323,-0.046477996,-0.03992817,-0.097572625,-0.012406623,-0.07931657,-0.07550884,-0.014386915,0.004690881,0.087781735,-0.010776807,-0.056724004,0.029191306,-0.087214015,0.05266807,-0.0053803143,-0.027751658,-0.047593284,0.009595283,0.05666103,0.008849522,-0.00760268,0.0014446562,-0.08101773,-0.012175247,0.0066022146,-0.048295412,-0.026344348,-0.037011895,-0.016186278,0.016735101,0.23988903,-0.072627604 +2.1.1.381,"The enzyme, characterized from the bacterium Streptomyces achromogenes subsp. streptozoticus, participates in the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin.",384,1.0,-0.060514987,-0.006869147,-0.16446577,0.0011006574,-0.002292268,0.06056586,-0.042244535,0.06612229,0.07835124,-0.017249485,-0.05168693,-0.013433106,-0.0032279363,0.06159526,-0.08057979,-0.016613066,-0.038749162,-0.038769364,0.06433139,-0.051422637,0.11050123,0.097102195,0.00021930298,-0.0330783,0.04918873,-0.011200824,-0.02437605,-0.04528923,0.002958687,-0.037307173,-0.0020931,-0.035977032,0.076820634,-0.037424695,0.1353862,0.10471978,-0.05182074,-0.052293822,0.1200729,0.005450968,-0.017908948,0.036735833,-0.034243565,0.04898159,-0.08042957,0.027037157,0.06704908,0.1111392,-0.010759708,0.00899484,-0.030365001,-0.07510566,-0.05366724,0.08089745,0.08381301,0.04411927,-0.036657557,-0.050002437,-0.011493877,-0.027699675,0.08735767,0.0029615138,0.03163097,-0.008609494,-0.04236755,-0.02647132,0.06503992,-0.0831316,-0.0046871295,-0.029924948,-0.057001382,-0.0045633786,0.058869734,0.025537051,0.029284889,0.0078081805,-0.033172064,0.008882793,-0.04305084,-0.0027466721,0.07127568,0.01661136,-0.0071508395,0.1125748,0.053545777,-0.01174244,0.021790883,0.018119846,0.06174177,-0.023951907,-0.021594012,-0.060237676,-0.014009216,-0.078753844,-0.042412296,-0.029452574,-0.10445099,-0.015716739,0.026727365,-0.03297555,0.0039098347,0.0066202246,0.059089605,-0.0018917259,-0.03201923,0.0075197853,-0.039096422,0.08811002,0.060705215,0.008158039,-0.005488454,0.04303449,-0.022226771,0.03366344,-0.024494724,0.04293059,0.08723945,-0.06477768,-0.09977152,0.035568196,0.03379619,0.020567257,0.00103598,0.02563755,-0.030830402,0.01100657,-0.0874014,3.0806658e-33,0.027228234,0.07006419,0.0039547826,-0.116221175,0.06387504,0.0086165685,-0.08909854,-0.0090559535,0.031400062,0.009570539,-0.06878592,-0.061646827,0.039920203,0.025198786,0.01992267,0.0516381,-0.03725979,0.061415948,0.048478357,0.01492814,0.04468938,0.065930344,-0.06215176,0.022925604,0.0074456804,0.07192441,-0.024046298,0.02138988,0.06213571,-0.054412503,0.030102829,-0.07374636,-0.06250367,-0.018630674,0.08395916,-0.07459801,-0.040059876,-0.05681012,0.054048497,0.0039639724,-0.053178217,0.034653883,-0.004852683,0.0016704688,0.06650615,-0.04600663,-0.06506483,0.008251577,0.056831963,0.056505814,0.05799724,-0.05424647,0.08434445,-0.00010446559,-0.10090288,0.024628647,-0.025413651,0.023797292,0.036104087,0.009679503,0.0012037674,-0.035489835,0.011119763,-0.055044588,0.014429715,-0.012639064,-0.02273821,-0.027523652,0.01139541,0.076880574,-0.08741239,-0.041289873,-0.0375778,0.068194315,-0.013027902,-0.04568311,-0.06755211,0.018600753,0.06205618,0.027952064,-0.018181387,0.0049052252,-0.037472848,-0.065253936,-0.06841197,-0.01279947,-0.014461103,-0.08170707,0.019131854,0.004939738,-0.036742028,-0.0780497,-0.09918914,0.01206828,-0.014297909,-5.497686e-33,0.10384781,-0.08423104,0.046504382,-0.051147237,-0.049938615,0.072367534,-0.054271165,0.007961299,-0.04914504,-0.034835186,0.073954314,0.0041966825,-0.006307984,0.036160916,0.021157717,-0.04740782,-0.0007508955,0.065332025,-0.0110223545,0.041744947,0.031347685,0.046898674,0.021749325,-0.04153587,0.04941756,0.013075976,0.021876799,0.088652685,0.041492805,0.047463287,0.012709828,-0.016948199,-0.07682549,-0.08461163,-0.034460455,0.050191645,-0.028425094,0.045601103,0.062422886,-0.06054145,0.15937202,0.024567334,0.06941466,0.1007747,0.021120762,0.047965936,-0.11431516,0.04071976,-0.02320418,-0.03831897,-0.023256782,0.06330381,-0.002635398,-0.04223341,0.010764792,-0.0043075806,-0.014156588,-0.037549797,0.0078628985,-0.006674948,-0.046142805,-0.023237675,0.028607564,0.029202623,0.023899013,-0.024277164,-0.012774993,0.047568895,0.102596596,0.030386616,-0.014127706,0.0013594453,-0.015039295,0.044655997,-0.054319553,-0.018556794,-0.07213075,-0.048895378,0.049490817,-0.034385383,-0.024251318,-0.0036221968,0.026006151,-0.013937928,-0.014950262,-0.04199441,0.0616221,0.044310022,0.04203426,0.05766038,-0.0362844,0.00966457,-0.02286518,-0.007554923,-0.019386819,-3.3484113e-08,0.061076332,0.014710028,0.083530135,-0.030786477,0.014478189,-0.053149678,-0.050986618,-0.027938824,0.021050742,-0.009657557,0.0137614645,0.0027362658,0.0034012399,-0.062119097,-0.04635511,0.02657794,-0.085128956,-0.017063564,0.00631403,-0.006162473,-0.0930963,-0.008381623,-0.11356424,0.07345357,0.0715138,-0.06506098,0.007082954,-0.020771807,-0.052907456,0.032282725,-0.0076237703,0.082924895,-0.008190585,-0.044222757,-0.0593412,-0.06031095,-0.03744088,-0.03774711,0.032970987,-0.075796664,0.04409936,0.07617728,-0.041838225,0.0074776206,-0.05008723,0.0040903073,0.0050451537,-0.064421274,-0.035455063,-9.731559e-05,0.045700468,-0.012054838,-0.061342213,0.005337373,-0.123706564,-0.0060314275,-0.015100685,-0.07551441,-0.053287532,-0.026796307,-0.021345945,-0.028393956,0.18281235,-0.041325364 +2.1.1.383,"The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-carnitine to tetrahydrofolate, as part of an L-carnitine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway.",384,1.0,-0.06410996,-0.038862225,-0.101979345,-0.028644592,0.041692216,0.05265458,-0.051098853,0.04153076,0.01835321,-0.058245115,0.011126755,-0.07092323,-0.026317818,-0.0628342,-0.067878164,-0.013322069,-0.073829316,-0.038395293,0.0115792155,-0.03636971,0.029090162,0.043447804,-0.06849733,0.008042907,0.02875398,0.044549156,-0.04200469,-0.030320477,0.0400837,-0.071074486,0.0109052,0.022196436,0.055443108,-0.023463476,0.01413496,0.09272175,-0.03450848,-0.07011424,0.06745282,0.027040547,0.05049169,-0.039279558,-0.050317723,-0.020131873,-0.053355906,-0.0072875754,-0.02096031,0.0074273814,-0.009913824,-0.031755894,-0.049805336,-0.046983484,-0.049168736,0.029199706,-0.0315796,0.022959458,0.06391258,0.0037658147,-0.007807311,0.022033144,0.057850048,0.06180407,-0.03111309,0.00559598,0.021056904,-0.042913906,0.05357553,-0.10815528,0.0061501395,-0.0011315751,-0.099320136,-0.052428715,-0.051428076,0.09902447,-0.002001261,-0.010146613,0.019507756,-0.056140706,0.041541632,-0.013835224,-0.007289464,0.04249355,-0.088812135,0.020403555,-0.03462502,-0.058336165,-0.04521333,-0.0054942206,0.10452003,0.0352865,0.03027072,0.009075507,-0.024088213,-0.035180904,-0.08047941,0.060829,0.088448785,-0.034503013,0.09702691,-0.017775191,0.0073785987,0.09254985,-0.037838154,-0.105118826,-0.11865078,-0.010064404,0.0051797675,0.07917984,0.017126353,-0.037283227,-0.029292818,-0.033642627,0.017776085,-0.08885058,-0.09200536,0.050202906,0.03705717,-0.064559035,-0.0019591383,-0.014095504,0.025931034,-0.035976663,0.09016667,0.043794762,0.038689572,0.0055262926,-0.07074338,5.8964284e-34,0.059343662,0.00013541416,0.00015996117,0.03894292,0.04205416,0.016545197,-0.08405079,0.045188405,0.003257491,-0.04632189,-0.07024257,-0.0850506,-0.020095158,0.06906857,-0.0040326733,0.040684212,-0.05736849,-0.034453586,0.024394661,0.011975104,-0.0065104547,0.026687765,-0.033281542,0.060062114,0.016084388,0.104177214,0.028556723,0.015096349,0.030261634,0.026777012,0.010915661,-0.05886594,-0.10813817,-0.023773994,0.08555484,0.01744242,-0.021251159,-0.008815759,0.029212492,0.0688314,0.121787675,0.043241464,0.028469926,0.010176369,-0.0026952634,0.020656904,-0.019334879,0.09057022,0.021188121,0.025353115,0.0622221,-0.046860583,0.083408706,-0.048471384,-0.09924853,0.121874966,-0.053939797,0.024174243,-0.026230428,0.015816506,0.050436337,0.07001466,0.0037536947,0.08341795,-0.005349934,0.038340576,-0.052230403,-0.022714306,0.06898215,0.004759077,-0.08732498,0.0037440609,0.12242646,0.06882721,0.045119405,0.009912436,-0.07181081,-0.036579065,0.040830564,-0.022342335,-0.07723977,0.0032226285,0.06218639,-0.067901224,-0.013887236,-0.014449315,-0.031097628,-0.024455868,-0.04173502,-0.012684842,0.02206735,-0.07271475,-0.016936097,0.014835432,-0.022311304,-2.575377e-33,0.047063664,-0.09672055,0.101754166,-0.06571398,-0.014212781,0.039314415,-0.0062824674,-0.014424686,-0.007883034,0.050768547,0.11949775,0.019940872,0.057053007,-0.024144568,0.054993052,-0.022072341,0.026287792,0.036526356,-0.077691846,0.008066488,0.0022964815,-0.027566772,0.016793605,-0.017583918,0.055725325,0.02415073,-0.068232946,0.034917347,0.05519667,0.019696504,0.07935475,-0.022471022,-0.012103967,-0.07321318,-0.074014485,0.0837631,-0.04159108,-0.0051158974,-0.0072497237,0.01430395,0.028340084,-0.026443006,-0.006433186,0.0021024004,0.011136039,0.019006856,-0.05174197,-0.08499818,0.011872975,-0.021989033,0.06574365,0.031176839,-0.040277872,0.050545834,0.019944057,0.0812431,0.03391124,0.02166531,-0.022601109,-0.06279934,-0.05030641,-0.01397067,0.032035217,-0.014862289,0.06505109,0.01409537,0.040267307,0.026811047,0.06472822,-0.055188343,0.12599687,0.057740185,0.039791353,0.042719167,-0.027502395,-0.028506828,-0.053697288,-0.045539014,-0.03807564,-0.03031804,0.012332793,-0.07140348,0.0011118707,-0.053162664,-0.047269993,-0.087658376,-0.047556896,0.097213596,0.008233671,0.045730367,-0.058896992,-0.014073426,-0.07216041,0.079932496,0.06360854,-3.9581753e-08,-0.0114711225,-0.05859553,-0.03475147,-0.027733017,0.010173398,0.049386013,-0.06668041,0.029887011,0.011936289,-0.04815623,-0.014008758,0.035167057,-0.023581987,0.053796243,0.010449649,0.04347769,-0.029017067,0.02181948,-0.00046478785,0.031230733,-0.06820705,0.0002975668,-0.04131178,0.02638891,0.033323165,-0.09605201,0.017919507,0.08822459,0.025262542,-0.055164278,-0.008998498,0.082875304,-0.03319256,0.014342263,-0.11718011,0.0370316,-0.03790846,-0.050394025,-0.073226176,0.075009145,0.07010523,0.027937768,-0.16003942,0.014521624,0.015764618,0.03291413,-0.042857878,0.062835865,-0.045258705,-0.007972582,0.017730467,-0.0050136233,-0.020434076,0.014774943,-0.04794464,-0.0257103,-0.046780422,-0.03956458,0.023713898,-0.052157763,-0.0126309525,0.029127294,0.19499484,-0.024452662 +2.1.3.16,"The enzyme, characterized from the bacterium Rubrobacter xylanophilus, is involved in a purine degradation pathway.",384,1.0,-0.06589844,-0.08350811,-0.10426188,-0.022826567,0.011818912,0.046604425,0.0017499621,0.039020885,-0.06999353,0.0065594963,0.015257506,0.0045230174,-0.0023380327,0.06839439,-0.02096741,0.10177568,-0.08405946,-0.007480041,0.09473697,0.011698691,0.096258774,0.016278313,-0.072215736,-0.018939996,0.020550327,0.007898052,0.039436415,-0.08277466,-0.048583027,-0.0400866,-0.016941002,-0.015475044,0.08309381,-0.09503864,0.12148861,0.10827816,-0.052195925,-0.07610906,0.06979781,0.028102363,-0.026644778,0.025765,-0.0280414,-0.005346873,-0.044445172,0.052986003,0.07036949,0.07163212,0.043606818,-0.013430972,-0.046320647,0.00018468143,-0.0037286768,-0.0354627,0.04536695,-0.044616453,-0.04944244,-0.10898761,-0.09530801,0.031829868,0.037606653,0.06970128,0.013244133,0.0098282825,0.073771365,-0.054033797,0.027983539,-0.07076891,0.010825003,-0.0049866643,-0.07579752,-0.07266682,-0.055606365,0.029428469,0.0032331632,-0.06148363,-0.010097504,-0.041533496,0.0060012178,-0.03148152,-0.0058460967,0.02874455,-0.014606447,0.060262527,-0.002114622,-0.004557181,0.0738453,-0.003722558,-0.016311673,0.081918195,0.009265053,0.021147475,0.023493854,-0.08289734,0.0082864,0.0038884438,0.020477464,0.010515821,0.053287297,-0.04129469,-0.07008944,0.039891653,-0.032097112,-0.08566771,-0.024128241,-0.07287491,-0.023169171,0.0755263,0.017487591,0.034032486,-0.03851859,0.01887173,-0.042228222,0.008962128,0.015720781,0.07753145,0.09664652,-0.045110684,-0.0840614,0.021611778,-0.010174024,-0.039363895,-0.036188725,0.1077223,-0.055840008,0.02268125,-0.040542196,-1.5647224e-33,0.032553464,0.009082809,-0.0367497,-0.042374067,-0.009113502,0.058409728,-0.046373773,0.007544446,0.020624325,-0.02676386,-0.05587657,-0.07810506,0.01253765,-0.017437719,-0.05790806,-0.009236926,-0.028706795,0.06746746,0.078502305,0.006693616,0.026321702,0.09841816,-0.04612444,-0.016883587,-0.013946489,0.105270006,0.015720801,0.026009127,-0.010828779,-0.049888123,0.013014852,-0.08059239,-0.09890981,0.00792932,0.08453709,-0.060690667,-0.019343685,-0.038033273,-0.009919063,0.06715506,-0.027281651,0.009046786,0.0021567137,-0.011333317,0.059970506,-0.013417465,-0.049580555,-0.013277112,-0.007144677,0.03623068,0.010100249,-0.0022259215,0.14448416,-0.008089279,-0.030192075,-0.012099559,-0.008961605,-0.014970268,-0.10440599,-0.0015125682,0.062646754,0.081478715,-0.023116574,-0.026740778,0.031015309,0.013749079,-0.027137294,-0.044391003,0.10948702,0.071420185,-0.121484,-0.018550811,0.026181098,-0.023557113,0.045239415,-0.062178373,-0.122298814,0.0961138,-0.002604182,-0.016258415,-0.07370183,-0.057466704,0.07666687,-0.0051825317,-0.0041966625,0.008668266,0.028669506,-0.041962024,-0.01979876,0.010527725,0.036787502,-0.0873686,-0.06163026,0.06786502,0.023796026,-8.442282e-34,0.07204137,-0.10453364,0.062773354,0.017697357,-0.09513575,0.01731871,-0.025260748,0.061469894,-0.008242744,0.021288235,0.020431777,0.009976417,0.0167183,-0.025590306,0.030194005,0.061242074,0.030134218,0.019537037,-0.092193544,-0.022774221,-0.08849641,0.113374785,0.011108258,-0.029251253,0.041304056,0.022998555,0.036352497,0.057090104,0.10369186,0.0054581743,0.03026477,0.021140551,-0.051613737,-0.04820968,-0.040072463,-0.027890492,-0.054688945,0.035424612,-0.019336982,-0.024925346,0.093407884,0.056371488,0.0078001176,0.05004216,0.021353062,0.06996707,-0.0966933,0.070402145,0.00839033,-0.013807895,0.02888044,-0.023838077,0.03433755,-0.02108806,-0.020155752,0.029049572,-0.009045637,0.036208343,-0.008307589,0.03207284,-0.052130587,-0.109664515,0.039543685,0.035790525,0.02902694,0.024485422,0.026577523,0.057361133,0.017787945,-0.03531506,0.08078084,0.052173745,0.013807951,0.06477188,-0.065277316,0.024090895,-0.06466155,-0.051822346,0.04502114,-0.02503809,0.001976941,-0.040670577,-0.056947622,-0.011422152,0.027038405,0.004439689,-0.015288828,0.08427671,0.01167573,-0.0126800155,0.017073318,-0.03750603,-0.0780914,-0.05092841,0.02679414,-2.4394712e-08,0.028838754,0.009499757,0.020139737,-0.011692202,0.030851638,0.044235975,-0.0045365826,0.0436171,0.11061437,-0.010784643,-0.0137117775,0.057978112,0.01797213,0.008673452,0.06711276,-9.111869e-05,-0.0407902,-0.027391378,-0.0035893593,0.036493607,-0.09966231,-0.07198323,-0.13151486,0.099015765,0.010103673,-0.090261064,0.1007533,0.04322856,0.012054675,-0.044704854,-0.0014953829,0.009867853,0.015184755,0.026724419,-0.06551969,0.051100813,-0.016675789,-0.06056795,0.03774254,0.0891573,-0.013113544,-0.001279033,-0.084179685,-0.0037466031,-0.019572806,-0.001415873,0.0038422868,-0.0057514207,-0.023653543,-0.0066166883,0.013158594,0.021192102,-0.0460496,-0.06688172,-0.037223253,-0.013065401,-0.017286705,-0.0704148,-0.0047100564,0.029031925,0.03543124,0.0011402057,0.17921348,-0.008278853 +2.3.1.305,"The enzyme is found in bacterial species whose lipid A contains 2,3-diamino-2,3-dideoxy-D-glucopyranose. Some enzymes, such as that from Leptospira interrogans, are highly specific for 2,3-diamino-2,3-dideoxy-D-glucopyranose, while others, such as the enzyme from Acidithiobacillus ferrooxidans, are also able to accept UDP-N-acetyl-alpha-D-glucosamine (cf. EC 2.3.1.129, acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase). The enzymes from different organisms also differ in their specificity for the acyl donor. The enzyme from Leptospira interrogans is highly specific for (3R)-3-hydroxydodecanoyl-[acp], while that from Mesorhizobium loti functions almost equally well with 10-, 12-, and 14-carbon 3-hydroxyacyl-[acp]s.",384,1.0,-0.10919321,-0.08848055,-0.13094655,-0.033559244,0.05260841,-0.018600393,-0.078699164,0.11446497,0.029693054,-0.037564542,0.01529459,-0.034826934,-0.052588698,0.111147985,-0.044376053,0.06425408,0.052071445,-0.026711738,-0.035140958,0.0133462045,0.11122868,0.02167359,-0.02258394,-0.058456432,0.0034364138,-0.030048518,0.009747442,0.0003007277,-0.05346357,-0.06431042,-0.034180984,-0.08682917,0.06501616,-0.008212263,0.1521605,0.015627995,-0.029365774,-0.031789016,0.095641114,0.029402096,-0.004123264,0.02475316,0.003858644,0.02353068,-0.046328068,-0.029527446,-0.04532007,0.08704176,0.050532445,-0.007274044,-0.030416057,-0.035383064,-0.055549763,0.08151749,-0.03784677,0.0085835215,-0.025541307,-0.024861194,-0.02487435,0.033247434,-0.050045557,-0.008168915,0.05683601,-0.0048681083,-0.0061276117,-0.037168324,0.030196747,-0.097349346,-0.0047106007,-0.023344979,0.0022035395,-0.035399057,0.015500181,0.014805751,0.051985946,0.018602021,0.01247062,0.0038174242,0.010862329,-0.0730831,0.030998666,-0.0065538045,0.028177718,0.05466522,0.004229337,-0.03486601,-0.03574469,0.052032314,0.004481201,0.016127609,0.016487593,-0.038823903,-0.06058221,-0.057269268,0.011285284,-0.01662672,0.09017803,0.03233169,0.0017763622,-0.032510173,-0.011346502,-0.016004214,0.005175178,-0.1196484,-0.082268916,0.011264494,0.04460885,0.044565637,0.048366513,-0.0172878,-0.07014871,0.06362157,0.014317201,0.06306575,-0.034908682,0.041756697,0.04002216,-0.065620065,-0.031997077,0.023959918,0.0062123784,-0.08823083,0.07389079,0.06354064,-0.004486501,0.096525855,-0.07951962,3.090959e-33,0.019854546,5.216053e-05,-0.038727973,-0.033663917,0.0074132294,0.007676905,-0.081437916,0.022393052,-0.04231947,0.014618269,-0.1145701,-0.06160216,0.020009832,0.06962896,-0.035015494,0.09002181,-0.01795478,-0.045848075,0.03898149,0.0049900943,0.11070252,0.021921098,0.024717469,0.026468722,0.059664804,0.08378551,-0.0010961564,0.068973675,0.06324833,-0.003013577,0.008198377,-0.10154926,-0.054375127,0.035346746,0.009727494,0.0221253,-0.05316262,-0.10312448,-0.008137743,-0.0053825346,0.0032384146,0.03012884,-0.043389305,-0.072594136,0.122580834,-0.03296108,-0.03174494,0.06116582,-0.0119588645,0.048085224,-0.0032809456,-0.020019222,0.07403559,0.022841215,-0.039452624,-0.053879116,-0.10394447,0.0038460735,0.103385255,0.030008266,0.057726096,0.07910138,-0.018336903,-0.02550058,-0.014750919,0.01692123,-0.05098398,0.03737455,-0.015713537,0.09374056,0.026916603,-0.035737664,-0.014997961,0.119153425,0.05147698,-0.099208966,-0.021198506,0.025545951,0.065311804,-0.016916258,0.03877766,0.02011679,0.062621094,-0.02738618,-0.06972288,0.0031080071,-0.027838992,-0.032971643,-0.032325782,0.029267693,0.0044214283,-0.034811296,-0.045795105,0.050380077,0.017968656,-3.81586e-33,0.06193719,-0.09351006,0.0645137,-0.087328374,-0.030390069,0.058133192,0.0062908293,-0.000904204,0.13238198,-0.04890742,0.052890528,0.022379057,0.019505112,-0.09378209,0.066429354,0.02171841,-0.116536885,0.030227639,0.047836747,0.021132687,0.0040221023,0.023683023,-0.016403671,-0.0025376785,0.040414747,-0.0074508456,-0.05900398,0.055521984,0.010554826,0.084935665,0.009395676,0.09769099,-0.03731238,-0.045189086,-0.04084445,0.015522531,-0.09159598,-0.019660547,-0.010236978,0.06014966,0.024993457,0.030590326,0.004937416,-0.026316186,0.0044347155,0.09548408,-0.089740135,-0.021186853,0.047465548,-0.062909186,-0.013757753,-0.037979487,0.004881067,0.013567768,0.08265746,0.08354602,0.026450206,0.054070566,-0.061684538,-0.09009822,-0.055013582,-0.057434794,-0.005885235,-0.002900747,0.08551395,0.10944083,0.022994073,0.0311745,0.0268344,0.09765487,0.003524242,-0.05440251,-0.025940217,0.042460114,-0.026142905,-4.5208737e-05,-0.067627735,-0.015764637,-0.02247869,-0.022691298,-0.009980398,-0.015263606,0.009646682,0.010477698,-0.03792443,0.027684988,0.038590476,0.063478075,-0.0080007585,0.03417953,-0.014202892,-0.011962402,-0.034409266,-0.0072786957,0.080820344,-5.2908934e-08,0.096133105,-0.023893906,0.06321726,-0.056834698,-0.009968183,-0.045575462,-0.025256138,0.046492066,-0.005043993,0.021738084,0.016315727,0.091586076,0.01504633,-0.054897845,-0.000353397,-0.030877005,-0.0042103743,0.013981977,0.021820832,0.02169645,-0.07136016,0.0087805,-0.034487,0.015715998,0.019674286,-0.0767913,0.007992884,-0.017728075,-0.019764459,0.014001638,-0.01906945,-0.016527511,-0.02169333,-0.1018609,-0.05185664,0.014557313,-0.09080168,-0.07879639,-0.0057721906,0.014278461,0.116653115,0.040331423,-0.0016738488,-0.005024524,0.059270397,-0.052580185,0.032039493,-0.05001519,-0.028417246,0.0063156667,0.0039023703,-0.03992329,-0.047660414,-0.05490518,-0.04541035,-0.010141055,-0.066876784,-0.083936185,0.009743786,-0.04238492,0.012946872,0.021443332,0.16041188,-0.02249672 +2.3.1.306,"The enzyme catalyses the first step of an L-lysine degradation pathway found in many fungal species. The enzyme is specific for acetyl-CoA as the acetyl donor. cf. EC 2.3.1.32, lysine N-acetyltransferase.",384,1.0,-0.044877492,-0.050681144,-0.08695575,-0.0035009447,0.17792964,0.049411993,-0.12400644,-0.0019190034,0.03288149,-0.0028159216,0.047823474,-0.01022017,-0.058054883,0.006209412,-0.09010398,0.08038996,-0.1272449,0.002273087,-0.032774452,-0.03219245,0.090530194,0.05700895,-0.02874634,-0.013661726,0.08057875,-0.08165394,0.0032672435,-0.048553597,-0.026899867,-0.12106298,-0.0079322085,-0.026730524,0.02858154,-0.04568584,0.053606205,0.07305186,-0.015855374,-0.03294446,0.13438639,0.06491388,-0.047792945,-0.07230689,-0.04741456,-0.03939779,-0.067125306,-0.026338931,-0.033714466,0.030342996,0.02057753,-0.0025516865,-0.0003679085,0.016703498,-0.03606305,0.02566992,-0.062630266,0.015846973,-0.04193961,-0.010962191,0.020221764,0.065105185,0.036614995,0.06753656,-0.03687331,-0.009557352,0.020098502,-0.08081495,0.053688858,-0.06264489,0.04403654,-0.025555823,-0.069058046,-0.0986771,-0.040348638,0.050549455,0.09082828,0.02586302,-0.01872739,-0.009226615,0.01245955,-0.008000651,0.020974008,0.008300034,0.012445316,0.036378134,0.039012056,-0.0386538,-0.04878689,0.036798943,0.05510772,-0.0044098133,0.044004876,-0.035575952,0.009718543,0.0100367265,-0.031837996,0.06283817,0.088253684,0.016613504,0.02965607,-0.0043198215,-0.023651948,0.02651017,-0.008566692,-0.04039872,-0.019961353,0.00728823,0.056852836,0.095277295,0.050898574,-0.04691383,0.031127807,-0.030498918,0.06567937,-0.0045458674,0.016229149,0.066522,-0.031282526,-0.023742333,-0.03756125,-0.010326486,0.051562943,0.03170822,0.024257146,0.05402488,-0.021173859,0.12436908,-0.024866834,1.7984889e-33,0.07375727,0.086094365,-0.03143358,-0.016287217,0.008840367,-0.046605922,-0.053097047,0.006580301,0.011975703,-0.019637952,-0.022715382,-0.06222827,-0.019634113,0.008358448,-0.07556225,0.02827464,-0.011596349,-0.06743165,0.023521954,0.077117264,-0.029484827,-0.008017128,-0.04619426,0.058695808,0.034571998,0.031041652,0.034338016,0.0710742,0.007841717,0.015750263,-0.040230233,-0.09338675,-0.056270458,-0.011303623,0.015346423,-0.02249311,0.04853603,-0.0562939,0.037739087,-0.009649222,0.03582837,0.08480323,0.00647899,-0.017781025,0.0124469735,0.012334336,-0.04033991,0.09583061,-0.03586709,0.013260015,0.062452994,-0.037427194,0.08026668,0.0017506436,-0.0468978,0.018261991,-0.06905949,-0.017307788,0.02763463,0.027808072,0.0661433,0.07282726,0.049362484,0.049181674,0.014359281,-0.033439506,-0.050070997,-0.05137286,0.009217322,-0.005509901,-0.103434116,-0.015986977,0.048336737,0.02065296,0.080568194,-0.056312885,-0.061626375,0.023455521,0.05541839,-0.017565275,0.0054103155,0.0081929,0.0111574065,-0.019956421,-0.0022402967,-0.031695854,0.02365018,-0.11239822,-0.02307023,-1.807964e-05,-0.01766876,-0.054612946,0.031157684,0.062034685,0.034042254,-2.5480157e-33,0.11772981,-0.098129146,0.08930263,-0.07811954,-0.10113201,0.049631108,0.008447325,-0.03814885,0.035012033,0.027928468,0.06801317,-0.027271071,0.02139518,-0.047755256,0.087491855,-0.011597992,0.03039368,0.0128496755,0.002369185,0.020971209,-0.024211077,0.053179074,-0.008396417,-0.0002886151,0.0790123,-0.0046965317,-0.04945116,0.054763604,0.04251009,0.00504762,0.006299393,-0.004425509,-0.0063279555,-0.04503437,-0.07425495,0.08651041,-0.0061685084,0.002431046,-0.0130696865,-0.015996816,0.029993769,-0.021320175,-0.01616003,0.012415339,0.011831039,0.042256095,-0.038761433,0.012293295,0.029174214,-0.10346396,0.030260485,0.005614394,-0.027749771,0.011358974,-0.0030008648,0.09702731,0.019891392,0.04243991,-0.01469523,-0.041439667,-0.08234458,-0.0053299307,-0.03501828,0.05444846,0.074543275,0.016752295,-0.038099367,0.103572674,0.037025236,-0.06321619,0.10854915,0.05003085,0.08567155,0.07824697,-0.013301188,-0.044356186,-0.09166947,-0.105026424,-0.034212776,-0.058261942,-0.030389803,-0.032393463,-0.004161186,-0.06602078,-0.07507253,-0.0886638,0.021546097,0.100046866,-0.01902941,0.026418215,-0.023155836,-0.06746135,-0.08729878,-0.005023036,0.0741988,-3.2154883e-08,0.05405436,0.0009672924,0.03749266,-0.080637954,-0.013000858,0.0147850895,0.027230592,0.075071566,0.069745235,-0.0058079306,-0.08704396,0.1387808,0.037727203,0.010877656,-0.007576622,0.01269199,-0.00057975826,0.06355202,-0.012888399,0.016967742,-0.042747032,-0.025031349,-0.020108368,0.010718544,0.0021104617,-0.08546979,0.056886725,0.030659521,0.015579038,-0.06184505,-0.0030712415,0.015103457,0.022558715,-0.056265827,-0.019175671,0.042391527,-0.051123094,-0.08212771,0.054475095,0.05057469,-0.04918389,0.012268313,-0.1262295,-0.007804131,-0.01750079,-0.040104516,0.0039349655,0.021091279,-0.017893782,-0.023791883,0.03363611,-0.051204998,-0.049214862,-0.06254107,-0.044582207,-0.047275975,-0.02539701,0.029722495,0.05874902,-0.1038849,-0.026458662,0.047678456,0.15609814,-0.045572206 +2.3.1.307,"The enzyme, characterized from the bacterium Streptacidiphilus griseoplanus, participates in the biosynthesis of the tripeptide alazopeptin.",384,1.0,-0.060451716,-0.0036304307,-0.18500622,-0.004891462,0.02228768,0.041821156,-0.008565345,0.03135096,0.070789196,0.017345324,0.0045978385,-0.059350763,-0.07147907,0.0298571,-0.07759265,-0.030278401,-0.07949461,-0.004844266,0.06385904,-0.040329374,0.103028625,0.0931021,-0.0047152056,0.03866087,0.034384184,0.030917509,0.036942683,-0.0057052244,0.00022700791,-0.09562935,0.005887961,-0.062337227,0.01253781,-0.006739808,0.07584331,0.11737122,-0.043265462,-0.03834654,0.09428261,0.01353616,0.0553654,0.022236273,-0.0016009613,-0.035040844,-0.028853897,0.012721977,0.027934022,0.077751726,-0.018867526,0.035933312,0.02148607,-0.059448436,-0.058362283,0.01966681,0.01788689,-0.005517606,0.0135573,-0.06833416,-0.020983588,-0.031217815,0.034762856,-0.04007863,0.07872143,-0.022134481,-0.09588541,-0.052222867,0.009260589,-0.096897535,-0.0068540354,-0.0353657,-0.07934152,-0.045928895,-0.00065434846,0.03517155,-0.01027214,0.02974617,-0.022362882,0.009523014,-0.03393075,-0.0073263026,0.10440899,0.009250615,0.0016835048,0.14517748,0.053008605,-0.025111962,0.033857062,0.011111123,0.05432671,-0.022974694,0.07115082,-0.050481264,0.024848513,-0.05213526,-0.063263126,0.01312342,-0.07847137,-0.104315996,-0.0058583566,-0.023105647,0.0037455584,-0.019809056,0.0031937226,-0.020031335,-0.010749144,0.006530263,0.005028781,0.08596724,0.083649844,-0.068129025,-0.04714004,0.03454473,0.05159667,0.06032287,-0.0055907336,0.019746138,0.043491714,-0.035174746,-0.045028515,0.05311428,0.021911453,-0.018691776,0.03618477,0.013471195,-0.015428295,0.046875373,-0.08989095,2.1128352e-33,0.08151519,0.027674196,-0.004311029,-0.059292875,0.016975582,0.026513882,-0.109419286,0.025002314,-0.0035097932,-0.07128162,-0.11137521,-0.1386934,0.016715111,0.082538076,0.009782596,0.033485558,-0.038238887,0.033402607,0.05107587,-0.062024914,-0.011662831,0.012277743,-0.07577625,0.014566926,0.081088886,0.08773536,0.004639345,0.052145723,0.026988659,-0.036583748,0.026827432,-0.04539511,-0.102674484,0.04732477,0.13977881,0.006454475,0.036256935,-0.079117365,0.06329983,0.023191111,-0.07144187,0.014466125,-0.005040627,-0.06519327,0.06321882,-0.010279057,-0.021403305,0.058338717,0.102381326,0.031047024,0.04105647,-0.0072136736,0.15907115,0.03060216,-0.11118975,0.043223336,-0.035441052,0.00409069,0.06557101,-0.009543204,-0.001440487,0.031416014,-0.0016560185,-0.034864552,-0.026677314,0.036708683,-0.0018825146,-0.055799615,0.008155769,0.02266488,-0.037181478,-0.016217904,-0.0325653,-0.007401265,0.00531945,-0.00726799,-0.0404256,0.01987655,0.07846222,0.011916271,-0.038016237,0.017490193,-0.022367043,-0.078310005,-0.042809725,0.0072938465,0.0025925692,-0.04958033,0.0064697214,0.018865848,0.017482307,-0.0061007966,-0.09644729,0.00804811,0.013636108,-2.5724166e-33,0.07067074,-0.09851843,0.017145783,-0.031200932,-0.056785516,0.008781927,-0.06576309,-3.112766e-05,-0.041240092,-0.04593294,0.053368032,-0.009306862,0.035427902,-0.029423108,0.038482696,-0.02911809,-0.014972141,0.05301685,0.07040908,-0.079165734,0.027848756,0.029666748,0.02612465,-0.12660338,0.07129244,0.009050766,0.0026742718,0.07522826,0.053264648,0.010485948,-0.038022164,0.0043035173,-0.09140909,-0.07117578,-0.057313018,0.05880686,-0.040153276,0.08054391,0.00956321,-0.068573825,0.07683696,0.003519233,0.06682391,0.0555238,0.109205805,0.042068478,-0.006737269,0.04168942,-0.018026752,-0.027964648,0.000891415,0.024249194,0.035115164,0.0062157367,0.023141999,0.0071651735,0.01842039,-0.047016308,-0.017335216,-0.023184946,-0.023566928,-0.023521649,0.0069078617,0.038468532,0.024464697,0.04832174,-0.010153271,0.06569878,0.08870367,-0.0057938113,0.07532352,-0.039407503,0.017187705,0.067382716,-0.04839591,0.021047756,-0.09584108,-0.017058091,0.054859754,-0.057412148,-0.014514605,0.01852201,0.027923977,-0.025354154,-0.07656646,-0.07967784,0.043582685,0.07747523,-0.0010157499,0.07503692,-0.042755682,-0.0224507,0.008737087,0.021562997,-0.02123836,-2.8398498e-08,0.01857101,0.010226476,0.055956624,-0.05751783,0.04156285,-0.031993676,0.037907023,-0.026374549,0.066760704,-0.06415277,-0.016453946,0.0018406105,-0.0028299706,0.021349527,0.029998407,0.09327126,-0.0567248,0.010219771,0.01073564,0.016037894,-0.05432993,-0.005399598,-0.12712225,0.067232154,0.00809072,-0.053190023,0.025754606,0.049975865,-0.00675626,0.010877553,-0.020445418,0.058401696,0.028771244,-0.053787384,-0.03701389,0.04236443,-0.10600803,-0.035298135,0.08510415,-0.0684146,-0.004113194,0.023882935,-0.0033424867,-0.03466425,-0.05563608,-0.0065276287,0.0544116,-0.010566836,-0.048198026,-0.04420526,0.031207802,-0.034740113,0.005323302,0.0034838826,-0.098603755,-0.036431875,0.020310108,-0.0909756,-0.021523377,-0.020197727,-0.008225545,0.02751508,0.14615823,0.007723112 +2.3.3.21,"One of the enzymes involved in a pyruvate-derived pathway for isoleucine biosynthesis that is found in some bacterial and archaeal species [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2]. ",384,1.0,-0.0050392197,-0.029224304,-0.09540326,-0.036836367,0.028106498,0.035824306,-0.11766004,-0.005734652,0.02417623,0.006229244,-0.031045238,-0.038437344,-0.080226585,0.03871093,-0.0072502284,0.045779042,-0.06017911,-0.013416138,0.08744594,-0.043539856,0.11978333,0.039966322,-0.008065816,-0.041476622,0.021967739,-0.0489347,0.047821082,-0.021613117,-0.028833427,-0.0361381,-0.01852527,-0.12782557,0.03458751,-0.09476884,0.08500591,0.095857956,-0.061324134,-0.017159335,0.047566872,0.008697042,0.0638761,-0.00016323039,-0.032782868,-0.004701217,-0.056335285,-0.010469398,0.06961921,-0.035173416,-0.05349984,-0.013591741,-0.050434563,0.00024884497,-0.10994727,0.036565397,0.037328213,0.023754707,0.0028945315,-0.00035013582,-0.02887848,-0.057944983,0.024580672,-0.015998665,0.021669213,-0.053042427,-0.036833797,-0.033003293,0.0397239,-0.08205457,0.0015483936,-0.08889278,-0.10624299,-0.08074826,0.028635422,0.026082462,-0.023740804,-0.0024765974,-0.012739067,0.0123781,-0.0012462903,-0.04525475,-0.0079162335,-0.04575792,-0.028898388,0.031275783,-0.024410807,-0.03178418,0.01241803,-0.04446958,0.0682979,0.051680177,0.037109423,0.016106784,0.020145616,-0.048330676,0.037188336,-0.004095756,0.045148093,0.055331066,0.023207042,-0.05458879,-0.008178182,0.07211766,-0.07633489,-0.060810212,-0.07900272,-0.0040692654,-0.020657077,0.06956928,0.049569864,0.00967657,0.007945705,0.050390586,0.0072071017,0.04268295,0.006489806,0.06528263,0.07150719,-0.0841715,-0.084662974,0.036972046,-0.009170076,0.005142167,0.12472064,0.06660983,-0.07654792,0.011051771,-0.07018394,2.3305577e-33,0.050425317,-0.027201278,-0.005703501,-0.03470369,0.012013248,0.018648857,-0.09377743,0.0027638988,0.023691509,-0.0010848774,-0.09015763,-0.12159457,0.06693069,0.037203524,-0.034313373,0.008563823,-0.022528403,-0.020881586,0.05744586,-0.019152291,-0.0053969035,0.042644802,0.023328701,0.030149896,-0.011378426,0.033388697,0.023010517,0.015079209,0.008181362,-0.021999577,0.031800915,-0.13501552,-0.061829764,-0.006928533,0.05940472,-0.036947355,-0.058501206,0.016479928,-0.0605886,0.03509725,-0.027021615,0.012098762,0.025878077,-0.0612845,0.084276654,-0.036042184,-0.016377738,0.15036702,0.0061598993,0.05742271,0.016270382,-0.03610575,0.06922585,-0.029722162,-0.06694004,0.031183166,-0.030282425,-0.019253401,0.07100914,0.010242518,0.05736514,0.11553876,0.026331747,0.025933439,-0.036808316,0.031187028,-0.060103282,-0.039933313,-0.039729476,0.07934731,-0.024096569,-0.026199719,0.049309935,-0.0049178484,0.028776262,-0.06906599,-0.08563585,0.056101106,0.053399876,-0.04092383,0.03438985,-0.01602615,0.06292767,-0.043319445,-0.013360587,-0.035632744,-0.06434303,0.004469692,0.01233297,0.11550755,0.012073289,0.0012476512,-0.017352622,0.041983787,0.04777703,-4.334744e-33,0.12482817,-0.13321905,0.04783999,-0.13150653,-0.028775657,0.07397071,-0.008201145,0.0016801915,-0.0023374646,-0.013710834,0.047809035,0.021338556,0.029272877,-0.031579472,0.06846644,-0.06288383,0.019256745,0.09221303,0.02010385,0.035601325,0.04231203,0.03966412,-0.09376332,0.01710457,0.04679761,0.0016699594,0.02038547,0.07837373,0.02961496,0.015979642,-0.020766092,0.052642167,-0.011671673,-0.03368486,-0.018680332,0.045375727,-0.07728045,0.0001954114,-0.036437657,0.032648865,0.009871634,0.051615197,-0.029465301,0.0442492,0.016752452,-0.009161673,-0.061062627,-0.017193967,-0.028077183,-0.04849834,0.017806554,-0.032338932,0.011347274,-0.041141186,0.079822786,0.089560516,-0.06398845,0.019998731,0.095227465,-0.058404226,-0.027328676,-0.08460813,0.059745878,-0.027535789,0.095089585,0.029732667,-0.011174423,0.050836936,-0.024814561,0.06540295,0.08434447,-0.029788224,-0.042183302,0.019784266,-0.04668076,-0.008442787,-0.051135823,-0.02281378,-0.019488957,-0.047583796,-0.006433771,-0.012019984,0.028833307,-0.12169076,-0.003810851,-0.065547846,0.04985423,0.10677169,0.0010063145,0.010589308,7.672378e-05,-0.063636206,-0.045857884,0.027092937,0.086297594,-4.4643073e-08,-0.01736634,-0.029964082,0.047811445,0.0431311,-0.048579894,0.009350674,0.028935459,0.006521402,0.024779614,-0.034699094,0.017856473,0.035544183,0.04678683,0.009254595,0.03671276,0.037260372,-0.06351644,0.05642833,0.009147381,0.030003019,-0.090884574,-0.03840629,-0.12888035,0.004291388,0.034210943,-0.10154379,0.025445571,0.03718833,-0.009205274,-0.06272864,0.03587791,0.03196173,0.058238093,-0.077818274,-0.052084632,0.005100281,-0.0064973505,-0.029404737,-0.0017770813,-0.0022568253,-0.0055013327,-0.0669563,-0.0017853025,0.04140244,0.063587174,0.05197428,-0.01405878,0.00501941,-0.09542979,0.024489766,0.08990467,-0.007828264,0.009438064,-0.053822283,-0.039278578,0.028798806,-0.00066258165,-0.07226073,-0.059269182,0.0074409237,0.07075861,-0.007922018,0.16632268,-0.029382098 +2.4.1.385,"The enzyme, isolated from the plant Withania somnifera (ashwagandha), transfers D-glucose to a beta-hydroxyl group present at the C-27 position in sterols/withanolides, provided the substrate possesses a 17alpha-OH group. Natural substrates are 17alpha-hydroxywithaferin A, 27beta-hydroxywithanone, and 5alpha,6beta,17alpha,27beta-tetrahydroxywithanolide. The enzyme's activity with withanolide A and withanolide U, which lack a 17alpha-hydroxyl group, suggests it may also be able to glucosylate the C-20 beta-OH position, although this has not been verified yet. The enzyme does not glucosylate sterols at the C-3 position.",384,0.99999994,-0.09690201,-0.017019317,-0.13416916,0.021074241,0.04010578,0.09395449,-0.14031334,6.709087e-05,-0.004438849,-0.023956932,0.066689655,-0.030924732,-0.121978976,-0.007808424,-0.043990728,0.05123331,-0.033979487,0.03321895,0.041828595,0.019779177,3.8556216e-05,0.014028639,0.026168322,0.030917093,0.06940353,-0.012021191,-0.02054997,-0.015185374,-0.0045148544,-0.06783116,-0.035236973,-0.033648025,0.023821464,0.009676636,-0.061822142,0.027805531,-0.101607166,-0.10337956,0.052397817,-0.025253214,0.054655783,-0.0007351371,0.05186687,-0.004333887,0.012439546,-0.043844506,-0.063535236,0.07249645,0.039919022,0.0005774091,-0.023880625,-0.073388875,-0.031292126,0.05403654,-0.07535091,-0.023751244,-0.040823817,0.030973112,-0.0020650977,0.05001616,0.056481373,0.005851505,-0.044068,-0.0058293007,-0.07318618,-0.05128778,-0.056081764,0.023994556,0.016554803,0.010674085,-0.019066632,-0.07219116,0.027217317,0.08136943,-0.031515732,0.071765125,0.016486788,0.07726615,0.03391683,-0.042830117,0.10421267,0.04425138,0.026214581,0.034160856,0.030095406,-0.004218997,-0.038499665,0.11191722,0.027868973,0.025879756,0.07000611,0.023980197,-0.05777947,0.062470388,-0.046392478,0.021792112,0.09947572,-0.0006515409,-0.0047424305,-0.024744416,-0.026656216,0.04177562,0.015519161,-0.0584705,-0.06165207,0.035346787,0.016246745,-0.032651857,0.052225195,0.026565848,0.03823456,0.0053131874,0.033485215,-0.008226304,-0.039626516,0.014936844,0.009182662,-0.12510064,-0.0630459,-0.04844658,-0.05846558,-0.072870016,0.053591985,0.054969087,-0.014021483,0.064795285,-0.035067685,2.6079222e-33,0.1160093,-0.031740107,-0.04493758,0.027475916,0.016978435,-0.014926617,0.023892805,0.030861067,-0.08042248,-0.08735565,-0.106144965,-0.098777354,-0.013797054,0.056102406,-0.033149503,-0.019373558,0.0957714,-0.026113046,0.10606424,-0.046555053,-0.041209143,0.06988429,-0.11770841,-0.015219138,0.054420684,0.061329298,-0.0757351,-0.0014256949,0.053577248,-0.01350155,-0.0046470147,-0.11099271,-0.10127576,0.04146393,0.09369257,0.029537907,-0.07520381,-0.029416125,-0.03707613,0.06287878,-0.0017029014,0.028178893,-0.06646032,-0.0073838276,0.022154937,-0.008244119,-0.01358497,0.09305921,0.050360736,0.068961516,-0.0188603,0.035682645,-0.004761867,0.068187796,-0.03156817,0.07986254,-0.0026901679,0.011031137,0.088301316,0.024771713,-0.016283756,0.066253796,0.018262526,0.052147772,-0.033691864,0.035526,-0.11198431,-0.024305336,-0.031033412,0.03922231,-0.04158655,-0.09011954,0.029012142,0.019573854,0.020018164,0.03473225,0.016207013,0.010612546,0.032870635,-0.034482177,0.030256173,-0.035752136,0.047858037,-0.040781412,-0.075152755,0.121589415,-0.01712643,-0.06922058,0.0008629002,0.017224718,0.009021435,-0.026524074,-0.042916425,0.03159971,0.044823606,-3.7939536e-33,0.09874625,-0.10301435,0.064320914,-0.069539554,-0.038084906,0.06800377,-0.0099620465,-0.09403059,0.008385277,0.009844048,0.0926259,-0.010326502,-0.017490378,-0.0014224361,0.025494099,0.022495396,-0.031227432,0.12908417,-0.047146983,-0.0032068125,-0.018465595,0.05431121,-0.03852104,0.06528521,-0.045786884,0.02629447,0.063761525,-0.03822099,0.049380615,0.054575097,0.028747562,-0.039948493,-0.019747328,-0.00806358,0.0010435565,0.03550357,-0.067103684,0.0037797822,-0.03846068,0.03754042,0.0040567876,-0.035012845,-0.05423681,0.03389619,0.07629251,0.026385859,-0.06902037,0.026305094,-0.032323215,-0.02013082,0.055818856,-0.009419154,6.9962865e-05,0.06859456,0.005219321,0.019684916,0.11952066,-0.039030794,-0.051252335,-0.10326745,0.019341744,-0.101087004,0.0008180112,-0.08659909,0.06157005,0.086244866,-0.0024541682,0.014771433,0.04368626,0.024204254,-0.0526732,-0.07074728,-0.0147178685,0.0685255,-0.019846804,0.003467446,0.018157957,-0.09491399,-0.023710929,-0.031917635,-0.044965398,-0.0011803433,0.06586325,-0.06201524,0.03136068,0.01055172,0.010706533,0.0466392,0.013469912,0.07951516,0.003275838,0.044539727,-0.061705925,-0.010414445,0.08596923,-4.6450065e-08,0.041151762,-0.034246527,0.020978568,-0.029092118,-0.061552577,-0.028703663,0.0147126345,-0.020864913,0.040386636,0.015758911,-0.027814519,0.055257488,-0.02993992,0.006130882,0.0328774,-0.05698348,-0.0091406545,0.04238179,-0.032048427,0.009488213,-0.087574415,-0.004516979,-0.014045394,-0.029205639,0.013409442,-0.08903911,0.014959972,0.10347459,0.011215683,-0.022956988,0.047671944,-0.019858541,-0.0033970124,0.031915516,0.006953626,0.042944744,0.02846811,-0.05622467,-0.016230926,0.0513751,-0.022910591,-0.057596464,0.0076232753,0.0625189,-0.024294306,-0.004689792,0.033413112,0.024352873,0.0072376337,0.044747148,0.008400212,0.002262002,-0.017004287,-0.07755938,-0.075993635,-0.010665395,-0.039811477,0.0092202015,-0.04806046,-0.05721524,0.030772677,-0.079557665,0.13213399,-0.010357947 +2.4.1.386,"Involved in the production of milk oligosaccharides in the lacto-N-triose (LNT) series. Cf. EC 2.4.1.150 (N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase; cIGnT) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase). ",384,0.99999994,-0.030121477,-0.13675275,-0.112950295,0.015705906,0.009339771,0.027142726,-0.06757452,0.072561696,0.061100565,-0.02455887,0.029893257,0.007932713,-0.048945706,-0.07203824,-0.06427756,-0.066512965,-0.029193446,0.037371833,-0.007261756,-0.059740838,0.085457966,-0.022128485,0.010034039,0.041229073,0.116366714,-0.10744527,-0.020738428,-0.06627629,0.020192986,-0.06888498,-0.040655747,-0.09584831,0.02641582,-0.024379397,0.06277473,-0.029128619,0.08136544,-0.08005258,0.04877583,-0.037877638,0.061578248,0.0010350065,0.04595408,-0.02443398,-0.046525013,-0.0039979764,-0.06683234,0.040812626,0.031340003,-0.011122619,-0.00027023512,-0.09135438,-0.070012465,0.026822368,0.0684081,0.014849152,-0.05566459,-0.049024347,0.075628966,0.11534899,0.028268384,0.020706728,0.02922166,-0.000115605086,-0.025600752,-0.05100123,0.10009667,-0.028882653,-0.035787974,0.043689292,-0.063530326,0.025611905,-0.005812769,-0.021621542,0.057103816,0.09849075,-0.012085965,-0.0131092165,0.03517791,0.034576666,0.008197658,-0.020313932,-0.007324553,0.059032068,-0.063674316,-0.12027941,0.026206309,0.04443574,0.03103647,0.012946109,-0.078386344,-0.024394453,0.019576734,-0.032645416,-0.064914584,-0.025696227,0.059927136,0.05430987,0.038164034,-0.03552245,-0.024905233,-0.013239384,0.08009854,-0.07197194,-0.07107383,0.046879444,0.0145186,0.028024847,0.0773948,0.0628143,-0.057455808,0.02975704,-0.014872923,0.0050475714,-0.14928618,0.0502608,-0.007747646,-0.15942389,-0.015980562,0.017059397,0.005066212,-0.002056851,0.11611014,-0.0013247547,0.009092099,0.037199788,0.0889115,2.4822971e-33,0.014613526,0.013354255,0.11397874,-0.017064238,0.04651012,0.018849736,-0.07890715,-0.031310465,-0.01365897,-0.018725786,-0.02538326,-0.040135637,0.023694549,0.060577888,0.044489425,0.09282686,0.04534504,-0.055819742,-0.026159612,0.044504102,-0.048013695,0.00089053065,-0.04362638,0.04212583,0.044802483,0.02542599,-0.022099627,0.03134259,-0.0070873154,0.018830253,0.080077566,-0.105321966,-0.080065854,0.04141424,0.047347166,0.008138984,0.04125622,-0.09410067,0.070919015,0.06444138,0.005463821,0.007909129,0.039770402,-0.0175427,-0.03794298,0.077817,0.033723507,-0.060952835,-0.003797843,0.043483544,0.009275858,-0.025741274,-0.013521062,0.03491902,0.0030226682,0.049849737,-0.09001454,-0.035924725,0.04014877,0.06651028,-0.0052086194,0.041871414,0.038421527,-0.02014697,-0.020619448,0.023730263,-0.054371428,0.014677711,0.02941483,-0.011874958,-0.062139396,-0.13804753,-0.016291115,0.00882128,0.054630585,-0.010812592,-0.0040980927,0.04274202,0.017863955,-0.029621463,0.026843619,0.048764493,-0.016858906,-0.050429445,-0.04383451,-0.019244531,-0.10495335,-0.0076580993,0.014283872,0.054125525,-0.007446938,0.004493807,-0.0410521,0.04652243,-0.041615143,-4.8910917e-33,0.1320935,-0.043054894,0.03258737,-0.08196078,-0.021912236,0.003323145,-0.012305126,0.059414838,0.028677484,-0.0154368635,0.056233834,-0.032974496,0.0074099363,-0.029482339,0.019536167,-0.0648813,0.0020644553,0.04792808,0.013987448,0.031832792,-0.002586574,0.009967845,-0.0014012147,-0.0013173448,-0.0033056415,0.035836317,-0.07354309,0.03599045,-0.030227195,0.068900794,-0.001869363,-0.01704758,-0.0033060173,-0.059447452,-0.10151721,-0.057689082,0.038097333,-0.037523236,0.0033235657,-0.013922199,0.0077098347,0.09790383,0.037926506,-0.045813635,0.024612889,0.08095621,0.010535809,-0.008013277,-0.0016529948,0.013300782,0.030417012,-0.007471797,-0.010775299,0.07321543,0.003027989,0.08000532,0.036904912,0.013029049,0.028408945,-0.010171626,-0.045737244,0.0014338908,0.016788052,-0.0948555,0.062023792,0.014146707,-0.06377207,-0.0033835485,0.107023805,-0.0097490605,-0.045840725,0.0334753,-0.022192229,0.050450474,-0.0060236254,0.011207361,-0.16842636,-0.08299938,-0.039025296,-0.02676772,0.012602293,-0.006166659,0.022729753,0.029031055,0.0055979826,-0.045224976,0.0630148,0.083644666,0.009192094,0.014524872,-0.06350117,-0.051739726,-0.08572744,0.12537552,0.047363117,-4.3142915e-08,0.01897117,-0.016414573,-0.01986275,-0.045936067,-0.052929897,-0.005850618,-0.08109928,0.009895512,0.028713873,0.009388681,-0.007949522,0.0697868,-0.033708375,-0.013906011,-0.04641786,0.022140777,0.0004499715,-0.033176262,0.0074154576,0.09310876,-0.11238753,-0.01561712,-0.02220654,0.045219965,0.008661479,-0.028668595,0.084060796,0.07965002,-0.040788516,-0.014352219,-0.0062533314,0.03993439,-0.03607019,-0.023576945,-0.029422946,-0.0436551,-0.058382392,-0.045436855,0.06575793,-0.0020729844,0.0041377544,0.05288423,-0.008956637,0.0047789337,-0.027887812,0.011731762,0.014931031,-0.003949037,-0.048407964,0.0019773114,-0.028084466,-0.07122429,-0.07408921,0.011121301,0.0064749406,-0.07512424,-0.034297746,-0.052159242,-0.011574943,-0.011566572,0.01626798,-0.074959375,0.1816306,-0.0035235947 +2.6.1.120,"The enzyme, found in many Gram-positive bacteria, participates in the reductive degradation of pyrimidines. In eukaryotes this activity is catalysed by EC 2.6.1.19, 4-aminobutyrate---2-oxoglutarate transaminase.",384,1.0,0.0027368094,-0.014646397,-0.06442102,-0.047288716,0.03059424,0.034462266,-0.056213915,0.091528125,-0.022307945,0.0257247,0.013257791,0.0077011404,-0.07979865,0.07916267,-0.0099164415,0.01243704,-0.13041891,0.016799776,-0.019661343,-0.089911446,0.044484317,0.011078258,-0.009276181,-0.01777191,-0.01776325,0.011849537,0.029836413,-0.052730497,-0.0061996877,-0.020048201,-0.015652489,-0.13657954,0.06817855,-0.078658395,0.099960074,0.09872647,-0.05804946,-0.080853365,0.05095163,0.0026138008,0.019178119,-0.023699353,-0.045751993,-0.032883164,0.0064045247,0.021274084,0.118657924,-0.0032306276,-0.0015042551,-0.0055057798,0.0024052537,0.016679395,-0.053412102,-0.025643677,0.02528634,0.03374975,-0.015029428,0.001933347,-0.047091737,-0.027329644,0.030313605,0.0074854,0.018014522,-0.04335297,-0.0072171595,-0.08202876,0.10528305,-0.028011018,0.03184241,-0.022250865,-0.064804986,-0.115121216,0.022782478,0.06845702,-0.016694449,-0.0376586,-0.00989692,-0.062131513,-0.008381886,-0.00095056195,0.015857529,-0.11689967,-0.018109275,0.021115288,0.007222357,-0.028078426,0.008356887,-0.03613098,0.059680615,0.041391913,0.0551493,-0.0013413712,0.022767318,-0.03255518,-0.053139627,0.02269967,-0.04380274,0.09018833,0.057357483,-0.04344096,0.021705694,0.0720368,-0.061346706,-0.030771496,-0.03680611,-0.021724865,0.017732574,0.10489051,0.022746112,0.006405536,0.013257477,0.05337387,0.023890058,0.0004126979,-0.0058365874,0.10574646,0.047409054,-0.031790484,-0.068179026,0.0555126,0.01851748,-0.011960331,0.09694617,0.09207771,-0.040936507,-0.012242444,-0.076824285,-3.2721798e-34,0.015055526,0.03692643,0.033619836,-0.014623524,-0.00085984974,0.028945103,-0.10416862,0.007048416,-0.017748699,-0.081155285,-0.09521578,-0.07014541,0.088614866,0.041435894,-0.028790953,-0.043249,-0.029320667,0.009420373,0.020996174,-0.007962785,0.032565597,0.023478277,0.06470048,0.024097262,0.033891227,0.033513326,0.01411404,0.015435151,0.0129048955,-0.014247025,-0.0012313108,-0.12901701,-0.10881812,-0.014262806,0.050152175,-0.015367791,-0.059813064,-0.025371216,0.0058733267,0.07459624,-0.0057294243,0.011200979,0.017508363,0.009737627,0.065002,-0.03173482,-0.028429681,0.12368132,-0.0022986983,0.034555018,0.011356408,-0.06945346,0.058249034,-0.004312169,-0.030254943,0.01598743,-0.024115553,-0.037125822,0.056116678,0.0636768,0.07451759,0.0959657,-0.042213444,-0.017099341,-0.0023373202,0.006637449,0.01758721,-0.001872391,0.025008295,0.048605815,-0.10573421,0.0010127146,0.05416416,0.048227943,0.019979129,-0.078362264,-0.067835346,0.085947044,-0.006071879,-0.046192586,-0.046005256,-0.036936108,0.018008804,0.008519459,-0.0013974217,-0.023911074,-0.024250763,-0.07051603,0.010476889,0.081620395,0.08508696,-0.06371307,-0.10012424,0.016421825,-0.0056469655,-9.029291e-34,0.084268026,-0.09483942,-0.05574006,-0.063357994,-0.062052976,-0.024810325,0.03599203,0.027915666,-0.031245407,-0.038482085,0.048930682,-0.0106828,0.012146411,-0.027361045,0.014005788,-0.033204567,0.009424513,0.08651328,0.0094252415,-0.014995855,-0.0028117418,0.027595026,-0.01620944,-0.0056837522,0.053381596,0.032900956,-0.005608882,0.014192593,0.101501875,-0.03910454,-0.03292073,0.0056960657,-0.06618654,-0.0036970782,0.0023730595,0.048455514,-0.03656353,0.005763302,0.032149192,-0.00627619,0.0673351,0.071988195,-0.017151507,0.031188002,0.0029290044,0.05818026,-0.06604923,0.040210165,-0.030758021,-0.0811412,0.0909532,-0.039846484,0.029437458,-0.0014522428,0.07892172,-0.058973774,-0.026396897,0.0101725785,-0.0032287186,0.034831513,-0.037324395,-0.09199633,0.05053386,0.016995477,0.040718753,-0.014874995,-0.0142411105,0.073462225,-0.005773365,0.03886365,0.08160742,-0.008635713,0.013657328,-0.019001868,-0.11991184,0.0009037153,-0.07210838,0.012440743,0.063581735,-0.059318915,-0.0042337715,-0.025564175,0.021062063,-0.082999125,0.029987732,-0.068354964,0.017622732,0.10435933,0.011319666,-0.023916872,-0.014594798,-0.096836,-0.021006163,0.06472933,0.05756794,-3.550688e-08,0.0059858826,-0.02225629,-0.0035989785,-0.0052990005,0.066906154,0.0716536,-0.010369026,0.061417088,0.024055013,-0.064535595,0.0005568552,0.042480562,0.035299804,-0.049647726,0.0015129328,0.10073509,-0.0965058,0.03230973,0.009710844,0.02598895,-0.081124656,-0.001188228,-0.18964235,0.05327021,0.040813804,0.0029225617,0.05081161,0.031244261,-0.008776736,-0.09510804,0.022343408,-0.021951986,0.047879215,0.0013887556,-0.02973647,0.0052544274,-0.019833425,-0.012628899,-0.033091962,0.010268378,-0.04043801,-0.016696183,-0.0605068,0.0021622516,0.046875242,0.051471524,-0.0149353035,0.06375804,-0.08431157,-0.018702062,0.10442918,-0.0096039595,0.030433454,-0.02922674,-0.13730145,0.01813507,-0.028141875,-0.07544371,-0.011867362,-0.015914405,0.054925103,0.03127138,0.18557478,0.0016839547 +2.6.1.121,"The enzyme, which participates in biotin biosynthesis, is found in haloarchaea and some cyanobacteria. It forms a conjugant between (7R,8S)-8-amino-7-oxononanoate and an internal lysine residue and catalyses multiple reactions, including a reduction, a carboxylation of the epsilon-amino group of the lysine residue, and an oxidative cleavage of the conjugate to release (7R,8S)-8-amino-7-(carboxyamino)nonanoate. During this process the lysine residue serves as an amino donor and is converted to (S)-2-amino-6-oxohexanoate, resulting in inactivation of the enzyme following a single turnover. cf. EC 2.6.1.105, lysine---8-amino-7-oxononanoate transaminase. 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+2.6.1.122,"This bacterial enzyme participates, together with EC 1.1.1.374, UDP-N-acetylglucosamine 3-dehydrogenase, in the synthesis of 2,3-diamino-2,3-dideoxy-D-glucopyranose, a component of lipid A in some species.",384,0.99999994,-0.11444548,-0.077622704,-0.12373125,-0.062904574,-0.0030849187,-0.014136012,-0.04560621,0.012837794,0.009746727,-0.004662442,-0.027168708,-0.08082617,-0.07062934,0.029293088,-0.023267604,0.00766803,0.009115912,-0.0071983226,0.007929086,-0.05237735,0.064894564,0.06416527,0.014952436,-0.0300717,0.062675595,0.0354221,0.09979517,-0.010328467,-0.033280987,-0.061130244,0.022836635,-0.13972573,0.14059989,-0.03381714,0.12003903,0.05297146,0.019502977,-0.02517223,0.074650064,0.042533904,0.01904506,0.040309273,-0.006006686,0.018889047,-0.035710633,0.028561918,-0.025776716,0.13948531,0.08153593,-0.05064013,0.016288055,-0.05592162,-0.03201883,0.043023873,-0.010628909,0.005468843,-0.037847605,0.0360604,-0.06473719,0.019292248,0.022274759,0.03480764,0.09288448,-0.014600257,0.025392946,-0.088095486,0.0437908,-0.11437477,0.023620583,0.012840722,-0.020652207,-0.057279434,-0.007990938,-0.013719273,-0.032629706,0.027261153,0.013817761,-0.056887507,0.05796718,-0.09555233,0.056543246,-0.05459102,0.02073781,0.11675641,-0.033894774,-0.08017752,-0.012179828,-0.009166277,0.033324365,0.009019662,-0.021270996,-0.08918216,-0.012947925,-0.008182833,-0.029011508,0.01209212,0.05315122,0.06554197,0.068110466,-0.03651474,-0.030439403,0.018303936,0.032277785,-0.04588146,-0.052045017,0.0073069036,0.028261267,0.066004306,-0.023200596,0.0036600833,-0.017773183,0.013081446,0.040356733,0.05195115,-0.086231805,0.027695466,0.047481727,-0.10039811,-0.08472921,0.01805272,0.05532233,-0.09212999,0.07498825,0.07305598,-0.032011744,0.035323124,-0.015610283,-8.8202427e-35,0.017168526,-0.024800159,-0.035558574,-0.027902149,0.008061641,0.013163112,-0.08543241,-0.0066451365,-0.055240814,0.011246297,-0.058444675,-0.080615245,0.10229159,0.14738001,-0.06370259,0.052145004,0.006637788,0.03556369,0.06849315,0.010630392,0.023490105,0.038176365,0.0030789024,-0.0052984864,0.046128985,0.04848366,-0.03309099,0.06121279,0.11151201,-0.0094537735,0.004749387,-0.13621543,-0.043393936,0.022398725,-0.012124291,0.02619723,-0.074701935,-0.06243557,0.0026448893,0.01497334,-0.0020895458,0.027373113,-0.013725882,-0.07735833,0.00797633,0.00048024865,-0.037744645,0.027781563,0.03806827,0.054322135,0.0391256,-0.0493415,0.10491137,-0.022898173,0.027146947,-0.037021663,-0.059621364,0.011497736,0.051070955,0.021268426,0.004064978,0.08760905,-0.09693457,0.00048808815,0.018761937,-0.026380219,-0.02796632,0.003360233,0.004161429,0.039213676,-0.03322549,-0.020417308,0.020008996,0.07018135,-0.04835483,-0.032866217,-0.003652076,-0.015595511,0.04114786,-0.04507057,-0.013499553,0.015413396,0.026292697,-0.02200787,-0.069185965,0.065143794,-0.05746509,-0.03924552,-0.0522937,0.074481584,-0.05479267,-0.06708032,-0.093669906,0.09001338,0.04317941,-2.7993621e-33,0.034852114,-0.06717107,0.0169465,-0.10413711,-0.07023521,0.11178563,-0.010488818,-0.0066410517,0.054262016,0.026745971,0.056507647,-0.026915474,-0.016212722,-0.046855308,0.045787755,-0.004560937,-0.08685769,0.008012978,-0.03395344,0.00678916,0.051039934,0.027702363,0.010045027,0.039032158,-0.015205051,-0.023448732,-0.0382073,0.06180184,-0.027897961,0.086826235,-0.011064669,0.0032733392,-0.021240346,-0.003021966,-0.0075577428,0.03733219,-0.033859305,0.007981882,-0.013613346,-0.007071571,-0.008255724,0.07250378,0.024447102,0.0169436,0.032620575,0.08943416,-0.064288266,0.041850124,-0.031928398,-0.054927923,-0.040844426,-0.010793578,0.031462036,0.055355553,0.043261237,0.05229762,0.032785896,0.071718864,0.016642079,-0.077738665,-0.058139533,-0.0930039,0.025745388,-0.021616127,0.069670044,0.058365244,-0.031753317,0.056269158,0.06056492,0.07116057,0.010160481,-0.010062138,-0.04643566,0.035360724,-0.031343058,-0.03852506,-0.1126441,-0.047847137,0.021414645,-0.014186297,0.056813646,0.0107999975,0.0038544207,-0.024746174,-0.011157614,-0.021503562,0.039258298,0.14469647,-0.0023411324,0.05987178,-0.01260385,-0.023682326,-0.08985855,-0.0024365035,0.030678743,-3.8191875e-08,0.059710678,0.00023112597,0.054174088,-0.051235974,-0.018620439,-0.0052983025,-0.004710311,0.06868283,0.024326313,-0.03169421,0.05231193,0.094392225,0.011971595,-0.012552654,0.0010234179,0.014665481,-0.06828409,-0.00430298,0.032294676,-0.011571372,-0.033020437,-0.0029642114,-0.112806804,-0.0036297757,-0.0012953007,-0.086217485,0.004139936,0.022079641,-0.033518035,0.01429464,0.0073919627,0.00831308,-0.017054858,-0.08466147,-0.028658535,-0.035783764,-0.08639502,-0.029220974,-0.01057447,0.04548506,0.09212419,0.06295203,-0.03880089,-0.004762488,0.004588198,0.03786917,-0.028890291,-0.025202887,-0.07172547,0.016063876,-0.003243455,-0.04684671,-0.010079958,-0.02407249,-0.10107947,-0.061293405,-0.08153976,-0.079554,-0.022600058,0.005274338,-0.010950798,0.0347875,0.13688865,0.012581636 +2.6.1.123,"The enzyme, characterized from the bacterium Bacillus subtilis, is a heterodimer. The PabA subunit acts successively on two molecules of L-glutamine, hydrolysing each to L-glutamate and ammonia (cf. EC 3.5.1.2, glutaminase). The ammonia molecules are channeled to the active site of PabB, which catalyses the formation of 4-amino-4-deoxychorismate from chorismate in two steps via the intermediate 2-amino-4-deoxychorismate. cf. EC 2.6.1.85, aminodeoxychorismate synthase.",384,1.0,-0.04331802,-0.08587904,-0.04168294,-0.08478231,-0.045320377,0.035306323,-0.032937393,0.025641752,-0.022562627,-0.005433389,0.04225649,-0.100532345,0.0026666133,0.013878853,-0.050975207,0.061667707,-0.108546026,-0.039697886,-0.01979731,-0.037267633,0.035865996,0.072749585,-0.062505655,-0.04577698,0.019367253,0.052572023,0.0812164,-0.07094531,-0.005999918,-0.04263054,0.043649428,-0.070614725,0.05905611,-0.024360266,0.07186197,0.047595225,-0.08637993,-0.017099686,0.15616567,-0.004985125,0.016716737,0.039802182,-0.042682577,-0.04396734,-0.056227908,0.04356655,0.053019248,-0.012393993,-0.015899893,-0.08882584,-0.020582747,-0.05792005,-0.030744545,0.05029284,0.035363823,0.023360176,-0.098014556,-0.04459075,0.0077398517,0.0037094553,-0.008819335,0.04992348,0.047728647,-0.0763928,0.045295,0.00073429965,0.07824095,-0.09541562,0.007224065,-0.06348715,-0.050646815,-0.0313396,-0.011490984,0.021975456,0.0063178316,-0.027578782,-0.07030617,0.034026228,0.06135386,-0.064641446,0.031784136,-0.044292968,0.048962444,0.11449024,0.020887751,-0.038663913,0.025150282,-0.025493257,0.1074692,-0.035228804,-0.0011472158,-0.007696498,-0.03743694,-0.024936948,-0.013815874,-0.038678873,-0.012743212,0.06437056,0.064628795,-0.045836523,0.032417722,0.05341971,-0.044401333,-0.0877537,-0.029465355,-0.046231043,0.10001473,0.09759676,0.06557693,0.011806621,-0.025001897,0.04247368,0.05488995,-0.060227327,-0.06010666,0.07294035,0.067868054,-0.012235143,-0.04131461,0.003547083,0.015727164,0.04530817,0.06355917,0.073570386,-0.063971415,0.043727133,-0.12111163,2.2912323e-33,0.088791385,0.015157071,0.061240457,-0.008486347,0.019178648,0.00285558,-0.077957615,-0.026279325,-0.020751448,-0.040589903,-0.103694506,-0.07014807,-0.016259613,0.05489244,0.015577102,0.03610102,-0.094928265,-0.002066073,0.013007034,-0.015774421,-0.014299688,0.04410998,-0.06058243,0.06795681,0.030016517,0.06445984,0.041702963,-0.015800323,0.011565775,6.9832684e-05,-0.011159142,-0.09651962,-0.123318635,-0.029865514,-0.021701654,0.016337303,-0.070527494,0.022111442,-0.014330868,0.048353955,0.0030221082,-0.0065599913,0.00023871248,-0.02909174,0.047886793,0.04112631,-0.025658881,0.09015165,-0.0107309595,0.06408518,0.011203923,-0.050293967,0.070537575,0.010236982,-0.034802824,0.0079615535,0.034802295,0.028394438,0.07908292,0.0689311,0.05169513,0.08277149,-0.07835492,0.02704125,0.021217834,0.043093085,-0.04733108,-0.014996781,0.037809312,0.05159206,-0.08993662,-0.032615043,0.03909903,0.04766966,-0.05403282,-0.061063934,-0.05858451,-0.002790942,0.017338479,0.018251644,0.009485131,-0.0049274205,0.0066519366,-0.041631613,-0.03169116,-0.09606702,-0.0063624983,-0.038393654,-0.08138864,0.040486544,0.054517053,-0.049343865,-0.051775202,0.022845274,-0.026913337,-3.5041858e-33,0.0974728,-0.05703751,-0.0056476546,-0.038004205,-0.05937966,-0.00012848368,0.024373936,0.011355262,0.007565209,0.017338075,0.03529892,0.027458783,0.039544273,0.022209294,0.011055064,0.034247458,0.0003169555,0.061226998,-0.012807278,-0.012232169,0.034339033,0.057769995,-0.026608452,-0.019226521,0.047585007,0.024646893,0.07792907,0.1264997,0.037311114,0.02489533,-0.0049267667,-0.004075742,-0.016584435,-0.057524044,-0.09457836,0.049160678,0.0037833792,0.0032987006,0.017240902,-0.05334231,-0.04764285,0.034386124,0.033862066,0.0670554,0.011667327,0.086477004,0.0084388815,-0.05013346,-0.07591384,-0.044107117,0.032583687,-0.004137611,0.0254444,-0.07386561,0.013282273,0.021577014,-0.037953395,-0.002322446,-0.032160915,-0.051630173,-0.03092643,-0.046127237,0.081408374,0.025936643,-0.04432061,0.073486425,0.024656866,0.023801202,0.02591481,-0.03039286,-0.0031860657,0.0062592607,0.042967193,0.04561521,-0.04050243,0.034621783,-0.06837301,0.003348008,0.03350916,-0.09034801,0.010135661,-0.07743143,0.031484645,-0.05627891,0.012738709,-0.06585203,0.044939835,0.14813858,0.023122216,0.03402863,-0.03937764,-0.011042466,-0.021433257,0.07006166,0.043264672,-4.401382e-08,0.017276492,-0.057673857,0.0069970805,0.0022303828,0.030370912,0.08643436,0.0038728304,-0.0025857054,0.04100258,-0.07417219,-0.0033206863,0.06981738,-0.0749953,0.020685691,0.022376008,0.037545737,-0.07677984,-0.012255341,-0.038285613,-0.02216752,-0.08322273,0.01348302,-0.07549349,0.049909316,0.034577608,-0.052374307,0.046981093,0.05211782,-0.037288237,-0.045641787,0.023315907,0.10694948,-0.034342844,-0.08123766,-0.09743999,-0.054145712,-0.048008636,-0.00757316,0.039347816,0.005227661,0.036503963,0.02211022,-0.11186827,-0.00776679,0.08022535,0.067739144,-0.056271784,-0.00078658323,-0.029892847,-0.0048494786,0.04723301,0.014140837,0.0529163,0.03983415,-0.11747742,0.044694357,-0.04965702,-0.046450544,-0.024609352,-0.034887385,-0.05006429,0.045866817,0.15227367,0.009752016 +2.7.1.234,"The enzyme, which has been purified from the bacteria Klebsiella oxytoca and Bacillus licheniformis, is part of a D-tagatose catabolic pathway. The substrate, which occurs in a pyranose form in solution, undergoes a change to the furanose conformation after binding to the enzyme, in order to permit phosphorylation at C-6.",384,1.0,-0.03208944,-0.024109775,-0.12067727,-0.027841585,-0.009153825,-0.00021321575,-0.0097190775,0.030645933,0.017144803,0.024327362,0.008129367,-0.033428438,-0.106932804,0.07441298,-0.04584586,0.08703086,-0.116113886,0.02066825,-0.024173688,0.03926084,0.07254839,0.0028010982,-0.015132239,0.0317446,0.03083942,-0.030242296,0.07666597,0.00013379811,-0.034848336,-0.041054904,-0.013119844,-0.025940366,0.02137381,-0.0077649453,0.035891604,0.04702501,0.020669146,-0.061836347,0.05665387,-0.013592761,0.06346502,0.018361568,-0.022577778,0.032775026,-0.06319305,0.06252897,0.0125235515,0.06401298,0.011843203,-0.028560748,-0.056051373,-0.107562214,-0.018364094,0.033023063,-0.007030495,0.09241763,-0.035702206,-0.053440094,0.027283838,0.0020644895,0.0084737735,0.01922127,0.0062433146,0.10925494,0.019154165,-0.062478676,0.0050816047,-0.041285515,0.002222598,-0.05125835,-0.030776422,-0.10849259,-0.028897114,-0.030039791,0.026284665,0.023993457,-0.021687513,-0.027402211,-0.0116027035,-0.06589258,0.057459358,0.025208218,0.0291427,0.09793558,-0.05112786,-0.036534328,0.022509092,-0.0423821,0.07794153,-0.024636898,0.070358306,-0.0011744496,-0.06865427,-0.08152798,-0.08685507,0.019995328,0.09453064,0.0752084,0.018347837,0.027914396,-0.03428432,0.027569743,-0.0142748505,-0.049512137,-0.072500564,-0.008907891,0.00019603208,0.08267986,0.028823715,-0.027401263,0.024682118,0.013087414,0.00823767,0.02187891,0.050714914,0.01462632,0.07849797,-0.09981352,-0.04839727,0.04639273,0.007676129,-0.016119575,0.032772485,0.011307494,-0.06862707,0.062085412,-0.075116575,2.3494499e-33,0.081331626,-0.012598659,0.031879947,-0.07963065,0.023065986,-0.04961798,-0.09387869,-0.08220807,-0.081396,-0.044156652,-0.07328236,-0.10395415,0.0036533333,0.025537929,-0.010786848,0.020538257,-0.0014343776,0.032076817,0.06302405,0.048326068,0.04309455,0.02723273,-0.019672487,-0.05001762,0.031051561,0.1279849,-0.027135113,0.01932311,0.047182187,0.0072554313,0.082630225,-0.050976336,-0.11771105,0.03828956,-0.012673055,-0.0049322466,-0.10527971,0.0015250007,-0.046899892,0.011262483,-0.00088299287,-0.06636613,-0.024314687,-0.047247086,0.06718697,-0.022602338,-0.023758993,0.07227135,0.005586269,0.045990933,0.05190156,-0.026119828,0.09365829,-0.04355908,-0.031997908,0.018053807,-0.014961002,-0.06487029,0.050806403,-0.013792468,0.03643901,0.034087554,-0.013601327,0.06948104,0.057438556,0.008328997,-0.018141538,-0.036932874,-0.0013376814,0.025237253,-0.09103498,0.0049953326,0.014220325,-0.010312924,0.024447544,-0.005321622,-0.08112713,-0.041427583,-0.052159525,0.008933029,-0.02209811,-0.08350738,-0.0076367822,0.0012278003,-0.037613105,-0.066031784,-0.033821896,-0.03424981,-0.042438492,0.03036537,0.039647937,-0.022210944,-0.12047067,0.014915682,0.05974369,-3.713851e-33,0.14747646,-0.08336173,0.027150018,-0.08168396,-0.043763574,0.06523246,0.011803761,0.061263606,0.026076777,0.0013805493,0.045903012,0.012590144,-0.09170372,-0.02069267,0.030382533,0.036805686,0.0022707747,0.120771,0.017270159,-0.029257923,0.019928327,0.059833314,-0.056752652,0.045744225,0.063867256,-0.03247443,0.007857759,0.089638434,0.056066703,-0.04018602,0.021430865,0.021425774,-0.010418363,-0.0322755,-0.019577945,0.041905638,-0.05870164,0.030071063,0.09630826,0.038748484,-0.0056734816,0.051712096,-0.0047250204,0.03009166,0.042107552,0.03344972,-0.06273175,0.02267864,-0.007628224,-0.06590541,0.056675326,-0.016088443,0.029167416,-0.0052736523,0.041899905,0.102115214,0.04544977,0.034990665,-0.03525521,-0.07959056,-0.08053797,-0.07706814,0.061104298,-0.009734878,0.055045977,0.03043796,-0.051761717,0.08376242,-0.019410295,0.018020298,0.07862827,0.0559465,-0.05608931,0.03602115,-0.02822662,-0.015607463,-0.069824256,-0.043862715,0.021883443,0.0070676487,-0.0028302795,-0.025742266,0.01774836,-0.01365305,0.062409226,-0.08688034,0.06282242,0.018033015,-0.04174699,-0.01426509,0.021210918,-0.050129138,-0.06330506,0.07747178,0.06089697,-4.0748436e-08,0.051039096,-0.09833421,-0.07625712,-0.023050087,0.036789715,0.047265258,0.012262185,0.0326173,0.024377862,-0.050930783,-0.0060243495,0.079358324,0.043123443,0.035203103,0.041919596,0.026892556,-0.0444916,-0.0461865,-0.04943006,0.039066233,-0.04937355,-0.041155785,-0.1393713,0.031344112,0.022740876,-0.051837623,0.010565514,0.06597627,-0.025577229,0.008577214,0.0622061,0.033347018,-0.06314844,0.005597978,-0.023413006,0.0069821095,-0.07443057,-0.11548443,0.009775727,0.04154133,0.03278842,-0.05877474,0.0011671174,-0.022860643,-0.012223905,0.01996336,-0.05578525,0.049793694,-0.017362408,0.033941012,0.056894373,-0.00029893033,-0.040538225,-0.059228636,-0.0963926,0.022454847,0.045131277,-0.06206324,-0.044359338,-0.03874552,0.065446734,0.03936184,0.18544541,-0.028986156 +2.7.1.235,"The enzyme catalyses the phosphorylation of L-glycero-D-manno-heptose I (the first heptose added to the lipid, Hep I) in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of some Gram-negative bacteria.",384,0.99999994,0.0040315967,-0.032851275,-0.09191243,0.02915796,0.0041946936,0.07858861,-0.026600026,0.044142634,-0.002728116,0.0645034,0.025600104,-0.014834404,-0.04047172,0.018332308,-0.047077645,-0.028356636,-0.015659524,-0.011385959,-0.050406605,-0.01501331,0.12967537,0.0535526,-0.062706575,-0.04859839,0.059290674,-0.03458329,0.01719321,-0.081547014,-0.02655144,-0.048571307,0.0022741088,-0.15400438,0.06944427,-0.086091936,0.0908347,0.08927183,0.031657267,-0.013767957,0.07992797,-0.035688974,0.0001869402,-0.00073596387,-0.019606357,0.009870272,-0.019700384,0.012692018,-0.025163107,0.053504847,0.04109726,-0.033475146,-0.03258398,-0.020499093,-0.07771899,-0.013274449,0.010605564,0.0059686955,-0.01965196,-0.008582364,-0.011635138,-0.0036588619,-0.009780823,0.0035639412,0.099050194,0.053737737,0.040017907,-0.1518966,0.08822888,-0.022482436,-0.029573658,0.022991033,-0.035423473,-0.028692558,-0.018016485,-0.008879564,0.07181349,0.019825967,-0.039909746,-0.014962916,0.030176478,-0.044517327,0.11003735,-0.0054118275,0.029971024,0.13429037,-0.052636456,-0.032454047,0.0045755347,-0.0044748276,0.05500954,0.06869206,-0.0070882533,-0.08336934,0.008661819,-0.0475196,-0.04739028,-0.057037,0.0020744104,0.02154067,0.03840363,-0.066188745,-0.013705088,-0.02350139,-0.03316251,-0.055594508,0.0059690913,0.07014539,-0.00791784,0.055161703,0.035788104,4.2200583e-05,0.04881826,0.025716562,0.045420673,-0.09645365,-0.039496645,0.04237684,0.041235816,-0.065622516,-0.041601542,-0.030831087,-0.0065013235,-0.042964146,0.040694386,0.03876787,-0.08364096,0.066770375,-0.01595431,9.760723e-34,0.023764461,-0.0040142937,0.02171596,-0.062445763,0.032686986,-0.05772719,-0.07020926,-0.046017665,-0.081195764,0.025063915,-0.041774698,-0.12439841,-0.041352104,0.08329337,0.015733695,0.08653875,-0.03338245,-0.011539404,0.024995241,-0.01959638,-0.032966103,0.0108955605,0.049126428,-0.04845133,0.11994312,0.10100705,-0.020829039,-0.009557218,-0.02131069,-0.011340487,0.05756947,-0.036712073,-0.06478107,0.03198067,0.11077615,-0.005367565,-0.0328744,-0.03557721,0.033667028,-0.03883393,-0.0023588866,0.06916141,-0.06291135,-0.041471753,-0.016260276,0.034961253,-0.043263804,0.046364445,0.090761036,0.0008350347,0.05327029,-0.04128397,0.049694963,0.034533467,-0.0276548,0.027703403,0.012177156,-0.0044027204,0.03901858,0.055257212,0.0044745323,0.06128544,-0.060233895,-0.017134916,0.023286702,0.017163776,-0.025004009,-0.009943,0.04387022,-0.0105317775,-0.07693357,-0.07240531,0.018492218,0.017975662,-0.007279853,-0.024401866,-0.047128335,-0.0008211255,-0.0149524,-0.014227431,0.09788173,0.02284353,-0.025707753,-0.051095832,-0.019459533,0.06208716,-0.07695541,-0.11340778,-0.020794362,0.08756267,-0.043111075,-0.0070013786,0.0045713284,0.10208837,-0.10040859,-4.7057026e-33,0.026397374,-0.091753274,0.07033048,-0.048956517,-0.06405208,0.04494035,-0.001545799,0.020819627,0.07367846,0.032715373,0.035900585,-0.018117305,0.026253818,0.05032412,0.016024582,0.0031812538,0.00031114125,0.07838547,-0.026226493,-0.07064633,-0.022822531,-0.013553653,-0.011654882,0.0015629942,0.11224549,-0.0004208832,-0.07365328,0.104910314,0.0007115994,0.008448699,0.07007507,-0.0062847324,-0.037872538,-0.053352114,-0.05011501,0.015800463,-0.09465229,0.008289223,0.03774045,0.012231193,0.0034379405,0.04695764,0.097569026,-0.06331926,0.03570029,-0.0062494944,-0.10541811,0.022635797,-0.028024098,-0.037019596,-0.009735737,-0.012474666,-0.0057470435,0.07541795,0.014842159,0.0790843,0.060361866,0.051389378,0.054919057,-0.109764956,-0.061911203,-0.083961695,0.047216617,0.006400116,0.06535635,0.06527978,0.01822294,-0.061451253,-0.008743165,-0.04192766,-0.017433787,0.0048376857,0.005360319,0.021929806,-0.012483839,0.02444455,-0.11486384,-0.06623854,0.040941987,0.0066092336,-0.0048728236,0.02919087,0.026734063,-0.03933698,0.024534386,-0.06885368,0.015933475,0.12736087,0.013748158,0.080241054,-0.056680977,-0.023053525,-0.02317152,-0.046351604,0.050502267,-3.8245943e-08,0.020215863,-0.05513356,0.040359847,-0.08332214,-0.0020970623,-0.0023197848,0.008952638,-0.0135649415,0.026168397,-0.023840105,0.0448842,0.09475873,0.03215039,-0.077086136,-0.034153223,0.0287345,-0.05432443,0.011894651,0.007869445,-0.0082792565,-0.07791288,-0.021357214,-0.11778508,0.047579307,0.010819126,-0.07269419,0.036662865,0.022546286,-0.03819654,-0.008075131,-0.0065924535,0.05902269,-0.022653654,-0.047578514,-0.061591808,0.0073179672,-0.0809856,-0.037143584,0.02046003,0.019527918,0.045398243,0.040902186,-0.0061787507,-0.0015463833,-0.015009995,0.05664893,0.011776823,0.04107335,-0.107482366,0.037484113,0.018804932,-0.039299835,-0.068599656,-0.047255855,-0.076902896,-0.07558229,-0.011677295,-0.0124862,-0.01910397,-0.017518032,-0.0011096782,0.011416541,0.18314794,-0.040178493 +2.7.7.107,"This bacterial enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids, much like EC 2.7.7.15, choline-phosphate cytidylyltransferase, activates phosphocholine for the same purpose.",384,1.0,-0.10556139,-0.04336688,-0.04787726,-0.03677239,-0.03940856,0.015657509,-0.020188902,0.041022703,0.017967943,0.02987661,0.014212835,0.00032197422,0.03728933,0.06596857,-0.029457808,0.053466618,-0.087794535,0.026157988,0.02194372,-0.03920779,0.043621898,0.0077710836,-0.048977878,-0.023376523,0.017718798,0.050888944,0.032242563,-0.0030337912,-0.019928845,-0.007684625,-0.015988765,-0.040454008,0.09224376,-0.114067346,0.035034362,0.07569796,0.00075842213,0.00066647993,0.034800325,-0.017777529,0.059099548,-0.013597735,0.034107003,-0.01423036,-0.023637207,-0.0074455743,-0.018355932,0.0402908,0.057405416,0.003136689,-0.0610823,-0.030301744,-0.0068065803,0.03256285,-0.017266685,0.13596138,-0.07151753,0.019998282,0.019046044,-0.07143257,0.0013810127,-0.0049197655,0.05527078,0.068617426,-0.01616517,-0.067373574,0.029621704,-0.06465019,0.029060373,-0.008626822,-0.0038603726,-0.07065922,0.046120964,0.02852599,0.08591069,0.0035404256,-0.007688593,-0.014176759,0.02170954,-0.033531077,0.019323353,-0.09202196,-0.0041919597,0.027476534,-0.026421621,-0.0150115425,-0.0044939653,-0.07115609,0.03095612,0.06269799,0.0060602766,-0.03988247,-0.0033442383,-0.0676924,-0.08839682,-0.01870134,-0.014670099,0.036979243,0.036843184,-0.004010075,0.022284467,0.043910105,0.0032505016,-0.09737479,0.02407728,-0.07002312,-0.007898035,-0.003296607,-0.018408963,-0.0025484893,0.007928633,-0.028461387,0.045012657,-0.04208957,0.0011544022,0.08376537,0.042948186,-0.045582555,-0.051047817,0.015156788,0.042959455,-0.08124498,-0.048512533,-0.012465419,-0.09700635,0.030867014,-0.085256115,3.0324083e-33,0.04905624,0.017681397,0.036995295,-0.05402584,0.0020105145,-0.05224561,-0.050920404,-0.040805686,-0.05304462,-0.105843276,-0.020783111,-0.027090672,0.064744,0.08123853,0.0061861933,0.02456607,-0.040243633,0.009951413,0.062355377,0.006878218,0.08396265,0.05295394,0.019604357,0.040328342,0.08550954,-0.0125898095,-0.014045657,-0.036945656,0.03151098,0.008646339,0.017405292,-0.0836419,-0.077759415,-0.05970278,0.04107675,0.02659476,-0.055526298,-0.091163576,0.025825487,-0.014361475,-0.0061104205,-0.04215978,-0.03701767,0.04786716,0.040755946,0.0012041854,-0.11436494,0.07805554,0.03187195,0.05668861,0.061373983,-0.03880059,0.051885065,0.004595449,0.013133683,0.028285576,0.014745844,-0.083493434,-0.0072611272,-0.013499297,0.01609547,0.027081108,-0.04540439,0.0118441,0.019856373,-0.0037405065,0.009593499,-0.10825007,-0.029663749,0.025217908,-0.07022826,-0.041442677,0.013629246,0.06114248,-0.06376913,-0.022081867,0.012175314,-0.0095770685,0.03892875,-0.01314508,0.051713504,-0.023061585,0.044038188,0.010806627,0.0136965,-0.042690754,-0.049666323,-0.1038178,-0.012839401,0.019078,0.02906531,-0.06545274,-0.08612556,0.08407523,-0.08973555,-6.4171515e-33,0.107515134,-0.06555853,0.08066706,-0.026985385,-0.0747035,0.11566291,-0.007149971,0.021026066,0.076077335,-0.0067415023,0.025932403,0.01891289,0.0790569,0.051467992,0.016474143,8.130325e-05,0.06736073,0.05713807,-0.034564823,0.011936639,0.018556988,0.05516183,0.03995678,0.1448254,0.014672523,-0.06972532,-0.04516565,0.028146833,-0.034005947,0.10027407,-0.04574925,-0.027184863,-0.07013237,-0.100799896,-0.04785624,0.060093317,-0.006417348,-0.0035190675,0.0037237294,-0.055711787,0.024573637,0.024582896,0.06855398,-0.039793707,-0.053612977,0.08043637,0.012712125,0.08157404,-0.11597335,-0.032615185,-0.0109321335,0.04634462,-0.012533168,0.04781486,0.003186517,0.043269616,0.0031281905,0.063676596,0.02077258,-0.050469857,-0.06484978,-0.1085009,-0.0028936055,-0.050505597,0.023757365,0.06958079,0.037887882,0.001647564,0.016631462,-0.057140112,0.040314425,0.06909843,0.0124507295,0.048473626,-0.052401625,0.04068284,-0.09402594,-0.12218757,-0.0014694066,-0.009501373,0.031035919,0.007753842,0.067819536,-0.053742442,0.03669058,-0.043009777,0.02950109,0.09194879,0.0036348272,0.03974964,-0.0017190573,-0.02914137,-0.063080706,-0.012910754,0.059314597,-3.7847148e-08,0.021169255,0.0033944775,0.060783263,-0.12137106,-0.03106415,-0.016809132,0.01843909,-0.015058336,0.043972068,-0.1119517,-0.010709613,0.07051464,0.026257768,-0.028415795,0.025571961,0.108289205,-0.04037579,0.06782452,-0.026032966,-0.0693001,-0.050786063,-0.019136183,-0.06078657,0.118338875,0.05053794,-0.0103584835,0.07439409,0.06949848,-0.0407356,-0.041029062,0.01881344,-0.015640216,-0.04263247,-0.043306835,-0.05930234,-0.00014881957,-0.05233915,-0.06199534,-0.0130379675,0.041825797,-0.014818205,0.025851397,-0.064472735,0.014039117,-0.053551126,0.038541906,0.00041435254,0.07085716,-0.066027924,-0.043869738,0.03412901,-0.024856567,7.010813e-06,-0.09837451,-0.1337818,0.010264995,-0.0019985125,-0.054127187,0.0055356803,-0.009016496,0.015976846,0.05086627,0.19568908,-0.008486712 +2.7.10.3,"This family of enzymes includes most of the bacterial tyrosine kinases. These enzymes do not share sequence or structural homology with eukaryotic tyrosine kinases, and exploit ATP/GTP-binding Walker motifs to catalyse autophosphorylation and substrate phosphorylation on tyrosine. Two subfamilies have been defined: P-type enzymes contain an N-terminal transmembrane portion and an extracellular hairpin loop domain. The intracellular portion comprises the catalytic domain and a tyrosine-rich C-terminal domain that contains the site for autophosphorylation. In F-type enzymes the extracellular transmembrane domain and the intracellular catalytic domain are two independent proteins encoded by two separate genes. The majority of characterized bacterial tyrosine kinases regulate the production and export of capsular and extracellular polysaccharides, but other members are involved in many other functions.",384,1.0,-0.038335435,-0.08272424,-0.07608622,-0.050835673,0.05168358,-0.019869605,0.03552798,0.08140905,0.112670675,-0.017241916,-0.007573892,-0.005539376,-0.049918216,0.14392246,0.0053374413,0.009148201,-0.16709015,-0.033139378,0.058057487,-0.06152713,0.060249485,-0.009320182,0.0224114,-0.016263817,-0.07692744,-0.037274428,0.08368209,0.021343619,-0.067542605,-0.018773004,-0.105216384,0.007017096,0.026337644,-0.028244205,0.06534562,0.088421375,-0.09743127,-0.015083134,0.05091616,-0.12499031,0.08484268,-0.04422046,0.0765739,-0.020911826,-0.048978046,0.051293727,0.014763635,0.028865306,0.037614983,0.0062786937,-0.01693856,-0.017195469,-0.0137014575,0.00033496032,0.007876104,0.09422844,-0.013131762,-0.009617491,0.029528266,-0.025989832,-0.0012446058,-0.073864274,0.018928465,0.0071509727,0.054151785,-0.021189561,0.01004134,0.012984844,-0.022271732,-0.0021632593,-0.09698696,0.005646181,-0.05048991,0.012237067,0.02426534,0.047056843,-0.061981797,0.028764032,-0.027210422,-0.045625176,0.021563813,0.015377327,0.044836547,0.077334866,0.03961384,-0.044186085,-0.040775537,-0.005244089,0.029917741,0.051988058,0.047951978,-0.06497298,0.06864988,-0.011421813,-0.08239613,-0.070448,0.045038942,0.034087207,0.012929914,-0.048499748,-0.031149257,0.022259194,0.05473367,-0.012408339,0.023465462,-0.003605211,0.019589528,0.074081324,0.0021509537,-0.03786858,-0.060181454,0.03605654,0.106118776,-0.052620444,-0.018598396,0.023111548,0.004909949,-0.0139324,0.000760985,0.028560845,-0.06989388,-0.05051699,0.028577862,0.015263543,-0.033107102,0.0126268845,-0.1149154,5.6203985e-33,-0.0024561614,0.06947191,0.036715813,-0.033273652,0.024572805,-0.03811685,0.011962721,-0.09919607,-0.036366858,0.0021166226,-0.066400096,-0.04391815,0.031244365,0.01374552,-0.018042855,-0.023494074,-0.025885183,0.013374338,0.0042370246,0.04755902,0.03827672,0.056990724,0.018153803,-0.07251453,0.07839188,0.034596525,-0.013738354,0.02461493,-0.034442306,0.018504886,-0.01183254,-0.01517631,-0.05365056,0.01740479,0.07295825,-0.021315467,-0.01298074,-0.041137557,-0.0009929391,-0.045075577,-0.014288478,0.00095934584,-0.059848394,-0.023727236,0.018165762,-0.039435577,-0.019691594,0.11860525,-0.057829406,0.07554225,0.092111945,-0.052732084,0.06704117,-0.010392831,0.009515704,0.00043844798,-0.046798915,-0.015284631,0.05196,0.028805077,0.11494748,-0.010270042,-0.012400453,0.021665717,0.012935586,0.03980559,-0.012150128,-0.077963516,0.025679257,0.12505205,-0.02731483,0.029378276,0.03109676,0.08094079,-0.019156672,0.017156884,-0.036794778,-0.033341937,0.00038318816,0.052587118,0.0071638017,-0.049140353,0.05358016,0.0022159016,-0.017260594,-0.04714595,0.0047254656,-0.094633244,-0.07129594,-0.011386529,0.008592668,-0.059232257,-0.040433057,0.14024971,0.0039240345,-6.648454e-33,0.110232115,-0.052570518,0.033801366,-0.14816417,-0.073896155,0.080398306,0.026502907,-0.10717591,0.024622066,-0.042749397,0.023163043,0.009661272,-0.01888588,-0.06118126,-0.008329705,-0.096021764,-0.013773101,0.084857225,-0.039520774,-0.07607742,-0.0034682353,0.018996822,-0.0027430176,0.059511762,-0.03395264,0.05171883,-0.09116079,0.10534504,-0.105381176,0.05502,-0.024442269,0.059446365,0.004701166,-0.050022945,-0.0032439856,-0.012169294,-0.03636492,-0.01663186,0.08729535,-0.00827579,0.05304925,0.040415324,0.06967773,-0.004711282,-0.05821513,0.058243476,-0.04835364,0.025893798,0.011506062,-0.056147274,-0.046947684,-0.005708458,0.0060565835,0.0019382101,-0.015780939,0.048223056,0.037885964,0.025525112,-0.0093209,-0.051002387,-0.078688756,-0.107919045,0.064444326,0.105465375,0.030374447,-0.048897058,0.011177908,-0.058540374,0.068203405,0.05853692,-0.03885057,0.043924965,0.0007700427,0.052594528,-0.007876394,0.027725402,-0.036709283,-0.07372423,0.074590616,-0.05986551,-0.050538026,0.021395167,-0.05056986,-0.011093149,-0.028883679,-0.011123641,0.02762751,0.02850826,0.018450135,-0.02416764,0.073339574,-0.007423328,-0.04582498,0.011660884,0.05342477,-4.6578375e-08,0.07288702,-0.0070084413,-0.009010281,-0.027260398,-0.041236352,0.060425196,-0.04749502,0.008526812,0.02729508,-0.016340783,-0.0026628564,0.040236816,-0.02601653,-0.03355601,-0.018494774,0.014326277,-0.0065752952,0.049000137,-0.035375804,-0.055502046,-0.01785109,-0.0011328802,-0.086574346,0.01129627,0.06696908,-0.0579269,-0.03516582,0.046852656,0.010511743,-0.00199283,0.03272413,-0.0028500452,-0.04300617,-0.027490374,0.0023614555,0.06462201,-0.06586544,-0.08393495,-0.08029395,0.041950397,0.052969016,-0.024393762,-0.030180626,-0.045763038,-0.059442863,0.096438535,0.039055843,0.029142102,-0.008842468,0.052177932,0.054946978,0.04540646,-0.017788982,-0.052354485,-0.1055945,0.12920287,0.009178312,-0.0037901604,0.029754477,-0.06861755,0.027947119,-0.031184312,0.14061846,-0.052227657 +2.8.4.6,"The enzyme, characterized from the bacterium Rhodospirillum rubrum, belongs to the cupin superfamily and contains a manganese ion. It participates in an anaerobic salvage pathway that restores methionine from S-methyl-5'-thioadenosine. The enzyme was assayed in vitro using L-dithiothreitol instead of glutathione.",384,0.99999994,-0.11540608,-0.027988063,-0.06450171,0.07615759,0.098827764,0.046838988,-0.011355522,0.060466632,-0.04602362,0.0024821628,0.0026999603,-0.08903767,0.0027895216,0.06525925,-0.03124159,-0.04860298,-0.051566254,-0.012443968,-0.019780418,-0.010542019,0.093084075,0.03896222,-0.04890045,-0.019252764,0.05264641,-0.01337868,0.059982225,-0.025616089,-0.09511811,-0.010581429,-0.06824614,-0.01832173,0.115900956,-0.0717736,0.05938506,0.12031669,0.02955356,-0.03029092,0.05398202,0.024908436,0.00046619834,0.027341675,0.12831193,-0.05131499,0.03265999,-0.0030002508,0.020650528,0.019427788,0.074466385,0.011015035,-0.08283527,-0.067499265,-0.0029778923,0.03620789,0.06947631,0.017742364,0.007032381,-0.07001614,-0.0682124,0.011437909,0.03819309,-0.046495784,-0.00522658,-0.007954772,-0.028337143,-0.08352909,-0.012776858,-0.020077962,0.10320858,-0.017608767,0.041173987,-0.00295638,-0.00058251974,-0.005094288,-0.032982625,0.036155596,0.050267767,0.025771962,0.03810484,-0.0633387,-0.026411235,0.0010482589,0.055228237,0.052101873,0.0364263,0.065151535,0.053752065,-0.050399415,0.018698081,0.024166893,-0.001850952,0.068848446,-0.04550845,-0.10119218,-0.13798922,-0.022020774,-0.032571677,0.060217787,0.010922276,0.03841829,0.03915124,0.061606646,-0.049608245,-0.124896675,0.0053832945,-0.04466084,0.019005768,0.097116,0.040266577,-0.019331543,0.07710043,0.039246373,0.011238731,0.054974545,0.03299769,0.09759185,0.05706641,-0.07849331,-0.10828468,0.05352832,0.003039807,-0.052335903,0.047124006,-0.009279054,-0.038596567,0.012687017,-0.06561351,3.3231905e-33,0.09643905,-0.0048893224,-0.026440745,-0.047217164,0.02759953,0.032740917,-0.114222534,-0.011299109,0.02381668,-0.034888178,-0.0924845,-0.025730923,0.00998109,-0.0051375567,-0.078035384,-0.060041357,-0.07781435,-0.00887861,0.045084428,0.009907766,0.04253135,0.04455544,-0.051737744,-0.0019978776,0.010142849,0.10563874,0.05887864,-0.034473106,0.0409941,0.0109808715,0.030404856,-0.057542015,-0.06468618,-0.0020319081,0.014710259,-0.0047478676,-0.054530084,-0.009960909,0.003482634,0.026128272,0.044888653,0.031848293,-0.070265725,0.029883316,0.030779634,-0.034697223,-0.07652246,0.030094724,0.039026696,0.012668519,0.006362102,-0.025926625,0.15506631,-0.024623262,-0.07173203,-0.020266445,-0.0055840486,0.021240424,0.014328608,0.066002354,0.06997884,0.028629845,-0.025383722,0.09718267,-0.0011384574,0.02434403,-0.0005800679,-0.056310635,0.056342978,0.031249035,-0.01007793,-0.082577415,0.020815885,0.038573507,-0.036916863,-0.062306743,-0.022349734,0.03383995,-0.04991135,-0.0030269162,-0.023826351,-0.0352144,-0.0066436045,-0.026254755,-0.052147754,0.06917449,0.02134353,-0.0754841,0.030273132,-0.03316869,0.072493814,-0.0064120153,-0.04746778,0.017590333,-0.05869386,-3.2435757e-33,0.04512774,-0.07264622,0.079625525,-0.07764215,-0.08562031,-0.0036622658,-0.017012872,0.00063703494,0.02253467,-0.07900467,0.08736439,-0.040077385,-0.00030789635,0.012444429,0.024220286,0.019653486,0.009654721,0.030382518,0.003377945,0.05085265,-0.03456305,-0.004965654,0.0285173,-0.005407876,0.111694105,0.046783328,-0.00760048,0.02725384,0.00059305574,0.0019962152,0.003619601,-0.033799544,-0.06710499,-0.08397791,-0.058051948,0.026087202,-0.034989472,-0.009057903,0.04298406,0.02521286,0.044888224,0.009311971,0.005371258,0.09972113,0.013621372,0.0031019223,-0.1309578,0.040370736,-0.07026023,-0.03295702,0.011906693,-0.11675525,0.009962269,-0.05062687,-0.013200311,0.041173093,-0.015771253,0.043777913,-0.052997265,0.027832627,-0.015528831,-0.09581094,-0.014297218,0.08007609,0.037288908,0.11130394,0.07216275,0.02556891,-0.016211312,-0.039557893,0.08279133,0.06639911,0.06468892,0.08632133,-0.011601638,-0.019186206,-0.07500071,0.046942253,-0.049820792,-0.015632374,-0.0072557162,0.0036419826,-0.05542476,-0.07173239,-0.019615106,-0.08216052,0.051188562,0.061843056,0.005597831,0.014691314,-0.07069838,-0.026055245,-0.04132442,-0.015023649,0.0480944,-3.7643705e-08,0.05195536,-0.11372314,0.009224404,-0.02503251,-0.02015915,0.023255737,-0.01695138,-0.04865154,0.040657133,-0.009813737,0.014179658,0.11446607,-0.0010493362,-0.057098296,-0.024659963,0.02940717,0.015432833,0.046452075,-0.023875425,0.068566225,0.00791652,-0.018898798,-0.068565704,0.049812622,0.017587442,-0.007284666,0.012212784,0.05227795,-0.033539016,-0.111786745,0.0043106945,0.016680235,0.03564455,0.025264455,-0.072524995,0.056653176,-0.04398837,-0.02116433,-0.02809973,-0.0048304535,-0.043178607,0.02769599,-0.06339606,-0.008124873,-0.052108016,-0.08432444,-0.013040926,0.03529075,0.019744806,-0.0045346017,-0.012701466,-0.005114831,0.028238123,-0.05398073,-0.092093304,0.017757634,0.03136089,-0.019141752,-0.06269923,0.05920176,0.012424502,-0.018084506,0.13902587,-0.038091607 +3.1.7.13,"The enzyme, characterized from Glycine max (soybeans), is specific for neryl diphosphate.",384,0.99999994,-0.10199153,-0.049689356,-0.03473072,-0.10590284,-0.018114952,0.01023998,-0.06691664,0.058355194,-0.039437346,-0.04730723,0.07906153,0.013922006,-0.04243673,0.046911966,-0.061958633,0.019625664,0.089841545,-0.007832716,-0.021877931,-0.077215366,0.07438204,0.05245556,-0.06500906,-0.09683388,0.042592105,-0.025951954,0.013216925,-0.0511237,0.023262134,-0.052876342,-0.06721509,-0.040424224,0.03712652,-0.053515114,0.066135004,0.070712455,-0.08240201,-0.075270124,0.051406074,0.04752045,0.05593475,0.008495691,0.022938706,-0.04494049,-0.066605605,-0.018813906,0.023667963,-0.006356047,0.070595376,0.024494953,-0.05325285,-0.028113443,-0.017732065,-0.025729667,0.04313542,-0.025871146,-0.04341081,-0.01701137,-0.08602806,0.023421375,-0.021660434,0.0164984,0.004415044,-0.019300137,0.06475437,-0.03589754,0.024251577,-0.033783145,0.006004741,0.008181247,-0.009394834,-0.084655546,0.041797325,-0.0036112582,-0.05313618,0.0063393456,-0.04709338,0.060160983,0.096518494,-0.047604717,-0.0044551454,-0.055371467,0.045504924,0.0028400263,0.018418133,0.0510133,-0.032128386,0.07492154,0.07486861,0.025178434,-0.00020129733,0.0039717196,-0.068107694,-0.0024587507,-0.053530093,0.06043659,-0.030519646,0.029752804,-0.045132436,-0.020620134,0.05425946,0.03752207,-0.035666138,-0.066933006,-0.04009026,0.0134371,-0.035362836,0.021555757,0.0072131422,0.009939763,-0.032714263,0.08541092,0.05344141,-0.0031004779,-0.04477574,0.05893369,0.04034696,-0.00087494485,-0.028213019,-0.020541636,0.07183813,0.031364374,0.05982932,0.07032862,0.0043155123,0.13894778,-0.08054085,-7.415034e-34,0.07627967,0.011337189,0.071375825,-0.04419699,-0.03849913,0.04935709,-0.10362617,0.054514907,-0.057015583,-0.06281809,-0.055479508,-0.051485494,0.029663442,0.023895329,-0.024998248,0.038334787,-0.024633847,-0.036720153,0.075819805,0.0012747986,0.07132494,0.037593514,-0.05748408,0.021550976,-0.0220689,0.009646803,0.010505507,0.019681793,-0.033160243,-0.015023985,0.005921288,-0.1307261,-0.04970164,0.05276153,0.05143893,-0.009560534,0.0011135931,-0.049269464,-0.02402789,-0.00017671837,0.0077328174,0.0241604,0.059065014,-0.050841115,0.029090803,0.0048519154,-0.023050763,0.04198537,-0.012025932,0.010439916,0.009513646,-0.03192994,0.10132122,-0.020096688,-0.0074393717,0.02384429,0.02168025,0.036381558,0.013532041,0.044641193,-0.076913275,0.015030424,-0.042702477,0.007406798,0.022804152,0.040715966,-0.09915065,-0.008508316,0.04530038,0.11944016,0.025050493,-0.03064273,0.08083406,0.055524677,-0.057926916,-0.077307545,0.015645206,0.008842129,-0.027053935,0.041182358,0.041459356,0.009506294,0.004770212,-0.04040121,-0.11842819,-0.0026160944,0.030249834,-0.042777892,0.010513381,-0.014406157,0.11237255,-0.008437377,-0.11541357,-0.0240755,-0.027937822,1.3912573e-34,0.08847427,-0.077129535,0.02746733,-0.005666158,-0.012957492,-0.07179472,0.10368824,0.00975711,0.026544511,-0.07024625,0.04589358,-0.00617198,0.021112442,-0.03808744,-0.037507348,0.05995157,-0.056097202,0.026717598,0.030713568,-0.045694903,-0.06647571,0.092494994,0.027184667,0.066463456,0.083814874,0.0012603913,0.0012390397,0.115467355,-0.062340796,0.026642364,-0.009348888,0.013128811,-0.07865206,0.015129451,-0.009445728,0.033496175,-0.042140234,-0.02458032,0.041519806,-0.011074642,0.008458169,0.1126579,0.020624256,0.082348965,-0.016317526,0.07422228,-0.08224462,0.021580504,-0.03798639,-0.075229235,-0.0387528,-0.037904125,0.04701944,0.03667751,0.028590083,0.0031737199,0.021093037,0.0062300796,-0.014083557,0.037527107,0.043398764,-0.019094573,-0.032797847,-0.005858431,0.029719073,0.06881042,-0.013955089,0.0510177,-0.00013920909,0.06555684,0.048074786,0.016901264,0.08674368,0.053950496,-0.023164831,-0.010898163,-0.013576558,0.025826968,-0.04795091,-0.08886935,0.008639256,0.029548153,-0.06647002,0.01976564,0.0049314247,0.028858067,-0.05324381,0.14096288,0.11524428,0.024999961,-0.08058346,-0.025378732,-0.09919836,0.085415095,0.0779145,-2.211788e-08,0.030951671,-0.08789287,0.015194347,-0.10566204,0.011487077,0.06862437,0.0048222826,-0.025474938,0.09747664,0.04069897,-0.040368967,0.068431996,-0.060180087,0.0028579168,-0.04585502,0.013456923,0.011384364,0.05470679,-0.025320468,-0.016733622,-0.06177387,0.048135363,-0.15409595,0.033512108,-0.010320539,-0.018160429,-0.013229572,0.06498358,0.04497865,-0.058354992,-0.052024078,0.0038861919,0.031008549,-0.081366375,-0.07531212,0.079780504,-0.02892562,0.011484814,0.0050687734,0.00013838515,-0.008460862,-0.031119965,-0.029766083,-0.017016945,-0.032156017,-0.048271608,0.0012458016,0.019987565,0.035749342,0.051996965,0.0010858623,0.011281578,0.008679925,-0.05119466,-0.10103203,-0.065192804,-0.066642955,-0.018422564,-0.0030206954,-0.04464303,-0.0124306325,0.022125551,0.17423332,0.003996537 +3.2.1.215,"The enzyme, characterized from the bacterium Bifidobacterium longum, specifically hydrolyses alpha-D-Galp-(1->3)-L-Araf disaccharides from the non-reducing terminal of arabinogalactan using an exo mode of action. It is particularly active with gum arabic arabinogalactan, a type II arabinogalactan produced by acacia trees. The enzyme can also hydrolyse beta-L-Arap-(1->3)-L-Araf disaccharides, but this activity is significantly lower.",384,1.0,-0.038112547,-0.0739184,-0.04006192,-0.009325134,0.040227994,0.006301093,-0.025482934,-0.048570737,0.054922186,0.043487895,0.021953855,0.03860658,-0.051499944,0.021976363,-0.020886222,0.07194647,-0.021658478,0.040118363,-0.031051422,0.02345374,0.12161612,-0.0029479384,-0.053299274,0.028914249,0.035068065,-0.02184852,0.037243757,-0.045184366,-0.04516924,-0.040611014,0.055917025,0.02580467,0.14421487,-0.07153105,-0.019104812,0.13841385,-0.064126484,-0.079176635,0.09129251,-0.024172917,0.042867653,0.015472489,0.060210146,-0.08804372,-0.046096012,-0.053007387,-0.028219236,0.048962124,0.09707001,-0.026840558,-0.040043145,-0.056070596,-0.04637962,-0.047371425,0.036707155,-0.08131597,0.00016371079,-0.01576871,-0.0011467919,0.070857316,0.052072503,0.08259202,-0.0007486049,0.008461295,-0.07839753,-0.027211862,0.003641018,-0.07311454,-0.0034188328,-0.025715714,-0.1053203,-0.0034329752,-0.06992904,0.008179819,0.026056316,-0.041028406,-0.027173636,-0.04326164,-0.028753867,-0.0338949,0.000114725604,-0.031232964,-0.012293921,0.024498448,-0.013010681,-0.044152748,0.025080528,0.027097458,0.0031265095,0.013279002,0.03307682,-0.014700496,0.019961879,-0.019424029,0.001332829,-0.017387163,-0.02647337,-0.010694481,-0.010924246,-0.014125801,-0.020523842,0.01694799,0.06939311,-0.11275247,-0.051994074,0.023142684,-0.01696778,0.07006284,0.074734576,0.006412187,-0.005024231,0.0072791777,-0.008308485,0.011478363,-0.058288563,0.049043722,-0.026300985,-0.1349181,-0.07853004,0.010726457,0.03681991,-0.075877525,0.119025335,0.029067732,-0.01817019,0.100604296,-0.0145626385,1.609351e-33,0.03444141,-0.08332083,0.020610329,-0.05034859,0.0017599371,0.027598066,-0.07420844,-0.014076639,-0.00608902,-0.019634737,-0.035586342,-0.032490585,0.016121214,0.08364785,0.001245772,0.014555137,0.0067143776,-0.05309336,0.06693456,0.07553704,0.009765478,0.035233874,-0.046973623,0.008549368,0.06502805,0.033618867,0.02020078,-0.023689356,0.062127504,0.009675094,0.05245935,-0.061609246,-0.14016812,0.0034350504,0.029804375,0.013397221,-0.05238251,-0.015402546,0.002878911,-0.009805671,-0.0019120973,0.016114637,0.0248698,-0.0021342107,0.047969006,0.014656708,0.009184861,0.09593902,0.027459692,0.11923923,0.055363517,0.032442477,0.05689835,-0.026698515,-0.037029505,0.026108753,0.03910192,0.06049491,-0.02194743,0.074601166,-0.020647587,0.04347756,0.0034540615,0.032358777,-0.053593587,0.036052316,-0.0011099664,-0.039016873,0.06668269,-0.03447433,-0.05212786,-0.02535878,0.04610994,0.065913424,-0.016455784,-0.054064758,0.018883038,0.009353929,0.02713979,0.057982758,-0.016634502,0.030925103,0.05061125,-0.039581887,-0.082929105,0.07369758,-0.07154411,-0.03877569,-0.007496221,-0.008575462,0.036133595,0.016603202,-0.08117665,0.097272724,0.058255047,-3.1785264e-33,0.10978658,-0.095147856,0.027123362,-0.04246473,-0.01094285,0.030665927,0.0322231,0.05477666,0.018970484,-0.02160102,0.087767065,-0.019997185,-0.0076433164,-0.062491912,0.086182475,-0.038169295,0.025371617,0.061742675,-0.11092927,0.0054313503,-0.0039996416,0.08443052,0.083790086,-0.070405595,0.012749248,-0.023689717,-0.01106711,0.054479677,-0.014554826,0.039641485,0.024111558,0.029566308,-0.08437009,-0.048123896,-0.07133503,0.0007699307,-0.09028338,-0.036220025,-0.0051119193,0.0017144304,0.014624684,0.0877588,0.046860695,0.0152438255,0.0041008284,0.05600354,-0.03556522,0.008341495,0.0070263967,-0.05479233,-0.043111667,0.0010513029,0.03514689,0.06701614,0.027306411,0.014600918,0.004805269,0.10592247,-0.10708285,-0.061712265,-0.07247119,-0.04887796,0.12655017,-0.050490156,0.038831763,0.023935301,0.016285392,0.015744245,0.06451541,-0.02376625,0.05908838,-0.0017646536,-0.036246017,0.09304707,0.031662736,0.07880457,-0.119751655,-0.10624074,-0.06209117,-0.04785915,0.033865046,0.06134142,-0.09838639,-0.07714009,0.005341005,-0.08525684,-0.01979807,0.06814133,-0.018775018,0.0529488,-0.00089694455,-0.027812898,-0.04586088,-0.0023509476,0.038771067,-3.7185284e-08,-0.070071965,-0.009537979,0.023733635,-0.068560965,0.008848001,0.05079796,-0.0031629067,0.06688214,-0.024405086,-0.013487725,0.022997726,0.055451095,-0.080411814,0.04567427,-0.032977156,-0.033471607,-0.02027309,-0.018768432,0.011426417,0.027506124,-0.060679067,-0.038134918,-0.13782622,0.051532857,-0.049980164,-0.07302075,0.0052436995,0.0013061664,-0.02375854,0.032529265,0.026438784,0.047087345,-0.060712896,-0.027982656,-0.06693495,-0.01665361,-0.05783391,0.025216896,-0.069723375,0.025812967,0.06725363,-0.05073237,-0.048561033,-0.042762972,-0.030135114,-0.0099043725,-0.040176883,0.064170405,-0.014949493,0.049097754,0.11916293,-0.04159465,-0.013325832,-0.03813372,-0.030718133,0.011741875,0.02454757,-0.079572946,0.023696832,0.031976085,0.020271592,-0.047575336,0.124492325,0.0014207095 +3.4.17.25,"The enzyme participates in a glutathione-mediated detoxification pathway found in plants, algae, fungi, and some bacteria. The enzymes from the plant Arabidopsis thaliana and the yeast Saccharomyces cerevisiae also catalyse the activity of EC 2.3.2.15, glutathione gamma-glutamylcysteinyltransferase (phytochelatin synthase).",384,1.0,-0.05310158,0.0036334707,-0.08893544,0.029256424,0.11143989,0.057885174,-0.054037955,0.018626234,0.04761241,-0.028227067,0.08476343,-0.04646969,-0.044354938,-0.056388486,-0.058095362,0.015795432,-0.0777473,0.020336125,-0.057911452,-0.09090766,0.022083709,0.038390543,-0.034529794,0.010240163,0.036758874,-0.016538434,-0.0015955457,-0.054832987,-0.018813059,-0.06591728,-0.01865458,-0.09502912,0.039972186,0.0031920746,0.013194147,0.083997145,-0.04923386,-0.10141941,0.07645455,0.01150226,-0.0050690575,-0.006901261,-0.03550158,-0.048665747,-0.019865623,0.0046780286,-0.0030712178,-0.042040758,0.03952954,-0.054962862,-0.0014080936,-0.04167668,0.0038225588,0.019676898,0.04928184,-0.031703874,0.010478004,-0.037645333,0.013428368,0.08091091,0.013057871,-0.04698511,-0.0018804825,-0.04032774,0.014873565,-0.035426263,0.025761703,-0.033426847,-0.0032503256,-0.08992933,-0.06846129,-0.07045846,-0.06529064,0.018367054,-0.016567057,0.05269531,-0.0464657,-0.03114342,0.020692993,0.009576616,0.0766509,-0.03965394,0.037435193,0.051690828,0.034418195,-0.039771944,-0.042636383,0.062582076,0.043888178,0.020789241,0.037105866,0.00091417826,0.025463698,0.02029587,-0.077738665,0.10360777,-0.008923014,0.053418573,0.008765725,-0.039808545,-0.002257539,0.0951447,-0.046159517,-0.071243025,0.0072786626,0.030656008,0.027708761,0.08794664,0.021175265,-0.04272355,0.022353722,-0.031628244,-0.014983952,0.017434662,-0.007975479,0.113917395,0.101655155,-0.03987206,-0.084155865,0.019711422,0.015726177,0.02580344,0.03094987,0.02991902,-0.037894253,0.038906645,-0.05206158,4.018319e-33,0.07060155,0.08452495,-0.032536626,0.009123582,0.022842893,0.0039806957,-0.078806,0.038807627,0.06298046,-0.08334432,-0.09929177,-0.025758658,-0.013561316,0.008851828,-0.049482062,-0.025063291,-0.0150062945,-0.06586125,0.069414265,-0.019972883,0.05997294,-0.08747807,-0.07363054,0.0026259457,0.033765618,0.08879789,-0.008622534,0.011744409,0.027238855,-0.024995232,-0.014518194,-0.06937679,-0.1011268,0.038561184,0.04835193,-0.04858496,-0.027879143,-0.009953197,-0.019873897,0.035520103,-0.027364489,0.031494815,-0.00863515,-0.042291336,0.06705075,-0.015314962,-0.050728574,0.059930425,0.09506007,0.09513729,0.010592145,-0.04409307,0.14226893,0.009553458,-0.0066119,0.0024277149,0.015755268,-0.06968408,0.0032926737,0.076231256,-0.033511978,0.081516705,-0.047967378,0.042144112,-0.0046908804,0.098892614,-0.087303646,-0.0064949794,-0.027933719,0.0858993,-0.064191446,-0.020734385,0.022022694,0.027446648,0.0029121952,-0.041538358,-0.117552966,0.03362455,-0.04690508,0.049823537,-0.028879218,-0.02320559,-0.028281186,0.0010945289,-0.05370434,-0.006217576,-0.040138524,-0.011212782,0.040533163,5.292854e-05,0.0678848,0.0031653915,-0.030279746,0.014569695,-0.0074223625,-4.3470013e-33,0.110658236,-0.066107936,0.0011920593,-0.13533127,-0.0005298471,0.05624584,-0.03417497,-0.014784153,0.071799874,0.03878863,0.0024944006,0.01609879,0.037743777,-0.041186,0.019027203,-0.051190224,-0.00211435,0.10175308,-0.070382304,-0.0070473775,0.012077582,0.05317718,0.021414056,0.0361854,0.09228767,-0.008379358,0.012703963,0.039369818,0.08329768,0.021039601,-0.03534789,0.02095583,0.0011937092,-0.009064234,0.0046181725,0.04506151,-0.051272914,0.036643017,0.03679517,0.034827776,0.033684183,0.036688708,-0.026015144,0.10593355,0.046554793,0.15377861,-0.08460876,0.038110737,-0.07005856,-0.0658972,0.023146126,0.042787332,-0.012938541,0.049842335,0.064629145,0.0007929509,-0.015235945,-0.014629343,-0.033082776,0.00094288774,0.0042395643,-0.064607486,-0.027253427,-0.016122594,0.013343221,0.018148122,-0.02444257,0.037642222,-0.04131218,0.079246014,0.09214774,-0.07507179,0.013517923,0.032878526,-0.09918931,-0.0046545826,-0.07838854,-0.008675717,-0.009083997,-0.053803686,0.054203086,-0.005816001,0.03645121,-0.09954933,-0.027951606,-0.08239637,-0.034197636,0.095067605,0.0013960421,0.025694855,-0.077661626,-0.009153625,-0.038992558,0.036536902,0.028370207,-3.7236724e-08,-0.012243623,0.008345597,0.05798475,-0.035092812,0.0025450152,0.045372088,0.044891793,0.11289402,0.030224597,0.016662404,-0.019106144,0.10735126,0.036068987,0.00011378792,-0.016692305,0.014673915,0.058037736,0.053083867,0.044851977,0.06627088,-0.033729035,-0.048989452,-0.0938612,0.01415806,-0.011677063,-0.080675825,0.030052798,0.06767783,0.008301239,-0.06873226,0.0491071,0.009741977,0.031529095,-0.026234623,-0.13242978,0.019853586,-0.012797249,-0.05695049,-0.011886117,-0.013383195,-0.045363456,0.039312463,-0.13284506,-0.005985648,-0.03830309,0.019525811,0.05287233,-0.0015068925,0.023458319,0.03791514,0.05141015,-0.06662145,0.008487399,-0.03682584,-0.10837313,-0.020824261,0.007645974,-0.01669764,-0.022196975,-0.032536127,0.007988296,-0.002250562,0.18346012,0.0047776895 +3.5.1.137,"The enzyme catalyses the first step in the degradation of several carbamate insecticides such as carbaryl, carbofuran, isoprocarb, propoxur, aldicarb and oxamyl. It catalyses the cleavage of the ester bond to release N-methylcarbamate, which spontaneously hydrolyses to methylamine and CO2. The enzymes from several Gram-negative bacteria were shown to be located in the periplasm.",384,1.0,-0.017878933,0.024208857,-0.08088704,-0.032329068,-0.0040845354,0.08623124,-0.041759364,0.03702328,0.045117352,0.0015354365,0.02818867,-0.012048011,-0.031573795,-0.044154856,-0.05022615,0.11318132,-0.026074804,-0.017114809,0.03037331,-0.00796195,0.045123134,0.039246894,-0.07809383,-0.05794982,-0.025095856,0.036445495,0.016146839,-0.01803598,0.0065933187,-0.07046414,0.0820029,-0.01352287,0.052821863,-0.050254393,0.112789996,0.0060279476,-0.028006684,-0.09306199,0.111735955,0.032331727,0.019150194,0.0928837,-0.07858928,-0.06799582,-0.038721547,-0.034630984,0.09671909,0.040416073,0.016503688,-0.10852323,0.016022408,-0.048645888,-0.013292482,0.003298636,-0.023439454,-0.079277076,-0.024777962,-0.028727498,-0.026567511,0.039909843,0.03813775,0.060398567,0.052221738,-0.023797026,-0.029456962,-0.06895219,0.046227504,-0.03974308,-0.0029790406,0.026114935,-0.09784823,-0.10514174,-0.0021184152,-0.037066635,-0.06536184,-0.021873947,-0.022995904,-0.018326439,0.05781743,-0.079528406,-0.042461522,-0.070792444,0.057358604,0.056836553,0.006877523,-0.06105778,0.013284067,0.035727322,0.1264772,0.07909304,-0.022085404,-0.010276917,0.012032136,-0.005771775,-0.09179467,-0.012702274,0.020990971,-0.02767416,0.029265376,0.0042203544,0.005018869,0.051406447,-0.038310084,-0.11505691,-0.075372726,0.07858363,0.03738843,0.0872636,0.11782131,-0.017397357,-0.06967465,0.06911498,-0.0033938792,-0.0033892065,-0.084450595,-0.009613819,0.0119326105,-0.025391046,0.003354981,-0.01937111,-0.0053858343,-0.028019117,0.014096272,0.019712841,0.015946953,0.029496484,-0.09619069,2.8209587e-33,0.029318074,-0.013985976,-0.051953696,-0.047468223,-0.024971003,-0.039723862,-0.06556869,0.027505696,0.06103174,-0.06704712,-0.00091464113,-0.13466874,0.019171048,0.022400133,-0.025205683,0.047202896,-0.013079789,-0.00992012,0.04696653,-0.007182055,-0.033641938,0.017307777,-0.06951616,-0.026750855,0.027040683,0.13448998,0.005083685,0.007185981,-0.0023164388,0.0029969553,0.0682078,-0.03349594,-0.10766173,0.029668605,0.10211481,0.022794569,-0.036547758,0.03755851,-0.028260184,0.042398445,0.013603235,-0.018447926,-0.010274462,-0.04166538,0.05003945,-0.033043668,-0.042346455,0.1686796,0.049611364,0.02310954,-0.0013423003,-0.034563243,0.076803766,0.0055495957,-0.06690932,0.09096647,-0.042152826,-0.04317062,0.0053631053,-0.008982085,0.01774832,0.019440016,-0.05257785,-0.03401611,0.05077486,-0.018254213,-0.0027665503,0.0012960919,0.035670474,0.021478936,-0.06738893,0.010418178,0.05534406,0.0724474,0.0008238683,0.0048511536,-0.024715401,0.010228966,0.05910253,0.037550554,0.008946295,-0.040547058,0.068155855,-0.14689694,0.014758278,0.001832515,-0.011272953,-0.08056304,0.00094465597,0.124411784,0.041092027,-0.076684825,-0.048986882,0.048477072,-0.023022378,-4.9156477e-33,0.025508279,-0.04113415,0.006702133,-0.07491517,-0.02092783,0.0051918975,-0.011442277,0.009748759,-0.08355041,-0.023514682,-0.012835013,0.035425078,0.046244614,-0.0029722177,0.028190063,0.030909305,0.060343217,0.03983353,-0.028434549,-0.09322142,-0.05445775,0.057284087,-0.0066103884,0.0029707637,-0.02831692,0.00727713,0.026780955,0.065541245,0.058047093,0.025288317,0.05887179,0.026102817,0.010694056,-0.039956596,-0.0025985,0.07910631,-0.09278238,-0.0077774334,0.041693226,-0.0016562263,0.023298526,-0.0094227055,-0.04630446,-0.039191358,0.008676795,0.012647464,-0.12156055,-0.030089507,0.017029865,-0.024950974,0.023053804,0.03558161,0.05020821,-0.03452291,0.032256458,0.037323967,0.026884202,-0.034393568,0.051505815,0.0014811442,-0.046055935,-0.0066997604,0.06006882,0.05947616,-0.0070161954,0.011958449,0.015973918,0.080745995,0.016089909,-0.025764678,0.05535076,0.07230124,-0.0024676137,0.037189495,-0.11110096,0.020029172,0.0106124,-0.08655324,-0.027285095,-0.117143154,0.039226864,-0.027978418,0.010475261,-0.0946429,-0.07007168,-0.010905132,-0.020224223,0.058395565,0.0020511828,0.005321903,-0.03319306,-0.014780799,-0.01780836,0.08729022,0.035092067,-4.3043627e-08,-0.04554152,-0.044063672,0.094912104,-0.050107427,0.028480183,0.096481785,-0.031253185,0.024218267,0.04420177,-0.034805804,0.0046565463,0.07530413,-0.03289249,0.030540152,-0.041281465,0.00085235084,-0.013639212,-0.04080474,-0.011241073,-0.010867185,-0.11362278,0.027325748,-0.0747222,0.013492625,0.07761494,-0.077983074,0.037205663,0.03365361,0.023361959,0.040378574,-0.019115098,0.10340231,0.031208267,-0.07417583,-0.05380403,-0.010120002,-0.00779441,-0.046582952,0.002421551,0.018464545,0.056019157,0.042806868,-0.077747814,-0.016604973,0.06738383,-0.015515581,0.013344686,0.041971095,-0.08756346,-0.04234116,0.08472971,0.021924539,-0.07237374,0.0049828896,-0.10446406,0.014594251,-0.011030019,-0.04371421,-0.018167704,0.00858526,-0.036643602,0.0038193725,0.1493141,-0.0024280788 +4.2.1.178,"The enzyme participates in an inulin degradation pathway, in which it forms inulobiose from difructose anhydride III. A conformational change in the enzyme from the bacterium Pseudarthrobacter chlorophenolicus results in it also catalysing the activity of EC 4.2.2.18, inulin fructotransferase (DFA-III-forming).",384,1.0,-0.0705202,-0.010920218,-0.14552371,0.0058834553,0.09983371,0.030027403,-0.053057645,0.06213658,0.047291957,0.004374071,-0.01883661,-0.040408894,-0.024705237,0.04429845,-0.041592445,0.010563388,-0.09459831,0.010597725,-0.026288792,-0.06441729,0.042213507,-0.002075321,-0.073473044,-0.023698514,-0.018748626,-0.017963566,0.0012048839,-0.054506026,-0.023188308,-0.07051124,-0.010435558,0.02023573,0.05780925,-0.051668473,0.09081645,0.11420038,0.038150713,-0.04645471,0.0836554,-0.051672723,0.0131960055,0.077409446,-0.018958658,-0.0066601536,-0.023038758,0.010790765,0.040039003,0.070848644,0.056373984,-0.020538636,-0.020668365,0.0015278581,0.070987664,0.022918636,0.0010014697,-0.010811033,0.011960165,-0.006917928,0.0009987936,0.0004723713,0.020144822,-0.004058641,0.0054567363,0.014222639,-0.011105439,-0.07760869,0.022882557,-0.07937104,-0.04953207,-0.05038697,-0.12562443,-0.048842687,-0.04494272,0.056884993,0.10663683,-0.00322466,-0.028741188,-0.017861614,-0.00089981785,-0.0017445654,0.060643375,-0.008989724,0.011785723,0.038434748,0.039479524,-0.09480491,0.01258061,-0.08586903,0.05941868,0.027169205,0.007398232,-0.025883168,-0.008095721,0.0056230826,-0.12694806,0.05609543,-0.049590413,0.028382447,0.08492894,-0.017481726,-0.0029405043,-0.006084815,-0.07692301,-0.031890694,-0.050654843,-0.020645652,0.015166066,0.123398475,0.05699347,0.019069398,0.02784038,-0.08334095,0.06563259,0.006261338,-0.015849734,0.053569265,0.05237866,-0.026016844,-0.04565804,0.0020964504,0.01884566,-0.0049554706,0.087176,0.061695006,-0.09456985,0.09819277,-0.09309919,2.6031618e-33,0.01076209,-0.018851826,0.016068421,-0.008006973,-0.027161561,-0.041115463,-0.06470938,0.025346613,0.012476288,-0.079478614,-0.041799407,-0.08608243,0.02964217,-0.0125365835,-0.045252513,-0.03570389,0.021542814,-0.05194418,-0.007025135,0.074839875,-0.030493742,0.0563883,0.0247315,0.03646492,0.12460944,0.05951909,-0.0015876445,0.03853086,0.045967925,-0.009673318,0.04195587,-0.09687148,-0.17416029,-0.015744118,0.039207637,-0.0021911694,0.0029572484,0.050579704,-0.06329311,0.06116829,-0.03876861,7.033436e-05,-0.04275936,-0.094359756,0.034113396,0.026901836,0.043723125,0.0839311,0.008972912,0.022078946,0.03606524,0.0030546794,0.04896,-0.03155279,-0.067248166,0.054790847,0.033938687,-0.027939338,0.06927006,0.04065836,0.018547157,0.051725246,-0.07215051,0.018762546,-0.038777824,-0.00451013,-0.017246505,-0.050738666,-0.019184537,0.021675847,-0.15041304,0.009635839,0.013145233,0.054073118,0.050123665,-0.057832744,-0.09934911,0.0055585722,0.040775146,-0.034144983,0.00069249945,0.049249403,0.034344252,-0.010445987,-0.039085697,0.004344058,-0.011319003,-0.031079995,-0.03521187,-0.0026808542,0.021812106,-0.044699453,-0.019634152,0.07059508,0.05718143,-5.009085e-33,0.06604755,-0.085829414,0.036995515,-0.089613825,-0.015121914,0.057959642,-0.013804909,0.03194411,0.03662951,-0.03261015,0.059037685,-0.013076347,-0.039826684,0.007889833,0.06270544,-0.0019300622,-0.013473669,0.10475126,-0.043797977,-0.02469129,-0.002636868,0.06298189,0.005068449,-0.005019489,-0.06276513,0.032029346,-0.008972314,0.027409153,0.09816338,0.024644386,-0.08003264,0.04276773,-0.011719779,-0.010991896,-0.061236877,0.0013130564,-0.062481962,-0.062351175,-0.022809654,0.030496687,0.024120279,0.10656609,0.009861483,0.012688981,0.01951038,0.043107037,-0.08234736,0.06075943,-0.021074625,0.04855429,0.047442712,0.006506,0.026042216,0.019771304,-0.004505205,-0.00041344186,0.048567377,0.060373258,-0.008690026,0.010831216,-0.10234053,-0.06300973,0.06213707,0.042637136,0.05984139,0.034768417,-0.043183696,0.10998485,0.036293328,0.025364153,0.025707675,-0.032525238,-0.03752225,0.01944639,-0.0079356795,-0.022113688,-0.107328,-0.013009532,0.03385941,0.07525039,-0.07572196,0.002190338,-0.013882615,-0.012581971,0.014802272,-0.12857954,0.013593142,0.03902183,0.03004958,0.028871955,-0.008310502,-0.048959892,0.0011681484,0.051263273,0.04557277,-3.8076116e-08,-0.0062020626,-0.06880582,0.027720403,-0.025865238,0.026416657,-0.006511111,0.016859319,0.017367916,0.063249156,-0.035648495,0.0014759135,0.08368164,0.021856325,-0.021426829,-0.0033878102,0.06744717,-0.027478851,-0.022980684,0.019223882,0.08757486,-0.05952065,-0.039186202,-0.1358898,0.05081889,0.0398264,-0.09261922,0.011199904,-0.0026813815,-0.049298737,0.0029745903,-0.040731538,0.06564791,-0.019850276,-0.026301956,-0.103657335,-0.03742141,-0.0467613,-0.07289401,-0.008722127,0.061250504,0.042658415,0.043150295,-0.08050974,-0.032198835,-0.007099444,0.03382363,-0.0032562101,0.03462466,-0.062502734,-0.03672875,-0.033960164,-0.020712864,-0.03828212,-0.017549714,-0.07759635,-0.024392543,-0.025808461,-0.036826476,-0.00907308,-0.050222542,0.010563255,-0.006797628,0.21178037,-0.006616336 +4.2.1.179,"The enzyme, studied in the fungus Aspergillus fumigatus, may participate in an inulin degradation pathway in which it converts the product of EC 4.2.2.17, inulin fructotransferase (DFA-I-forming), to inulobiose, though in vitro activity was higher in the direction of DFA-I formation.",384,1.0,-0.027812503,0.03275141,-0.13202885,0.012773132,0.10641473,-0.0003128982,-0.064771295,0.10006474,0.036008295,-0.017865114,0.035988703,-0.03714213,-0.026427556,0.06537304,-0.08937434,-0.007140879,-0.026758619,0.042689383,-0.03273192,-0.06118447,0.047503088,0.038698386,-0.01886703,0.0028436566,-0.01475703,-0.065284334,-0.054493006,-0.03185538,-0.0044946773,-0.13145585,-0.034722757,0.03965795,0.03801934,-0.081463024,0.06626433,0.116810285,0.017367689,-0.026092546,0.09937694,-0.032449167,0.028562248,0.0145674255,0.043553628,-0.05309349,-0.028057134,0.0059704008,0.06462273,0.04226618,0.06628273,0.008856283,-0.044394914,0.013998177,0.08053156,-0.010847323,0.017788062,0.031032886,-0.032978613,-0.037870884,-0.053957276,0.041683238,0.03426997,0.005027228,-0.03212581,-0.0013180397,-0.059963875,-0.04793863,0.0203216,-0.058038834,-0.071564145,-0.015415419,-0.08035173,-0.057634797,-0.015979886,0.093159586,0.093295015,0.033254527,-0.01868716,-0.03289423,0.036371395,0.03857365,0.09397713,0.00878654,-0.030654512,-0.056551307,0.028608587,-0.0651223,0.028226057,-0.04021437,0.026953934,0.047215257,0.03835775,-0.013835039,-0.0071627307,0.02117932,-0.064163215,0.0649374,0.021077793,0.14080517,0.09232717,-0.026146308,0.012030986,-0.028829135,-0.07730205,-0.028998867,-0.021531802,-0.06905906,0.033140995,0.10564215,0.06575435,0.025301842,0.020162929,-0.12629038,0.045991104,-0.01274943,-0.018693605,0.04336455,0.03456854,-0.035238523,-0.03198182,-0.013572197,0.035305195,0.022694763,0.10248496,0.03819357,-0.051800795,0.08191813,-0.040142152,-1.0528022e-33,-0.007482644,0.011593649,-0.022773111,0.009662212,-0.019583175,-0.059879836,-0.039708294,0.0050669415,-0.0017820607,-0.078820035,-0.079330444,-0.06898865,-0.036691155,0.07346846,-0.045194235,-0.010115907,0.044216547,-0.104037024,0.005615429,0.035162076,0.03857571,0.039486498,-0.03171215,0.040885683,0.08876969,0.05847636,0.012293404,0.022579493,0.030830946,-0.023235977,0.02566491,-0.06720153,-0.15118538,-0.028580176,0.046422187,0.0064658555,0.034151215,0.025103476,-0.046674248,0.015005725,0.001281598,0.044928305,-0.037162036,-0.1143349,0.02999163,0.033076815,-0.00038232046,0.0746063,0.04179803,0.030300017,0.096600465,0.0061897454,0.07204223,-0.017788736,-0.028989518,0.034123655,-0.00015094547,-0.027446026,0.029079413,0.061707467,-0.07416705,0.01773159,-0.060410686,0.068975665,-0.058737457,-0.030755289,-0.018866856,-0.043342225,-0.022030976,-0.013124221,-0.09792947,-0.02405746,-0.03758139,-0.013114166,0.0397185,-0.06291488,-0.122019835,0.013052169,0.008037283,-0.059766684,0.023906808,0.07155535,-0.0005188112,-0.019081326,-0.029494222,0.0075610694,0.0096319625,0.004501094,0.016465226,0.0027007782,-0.013007377,-0.052667804,-0.038467377,0.081961505,0.0709226,-2.5456469e-33,0.061464388,-0.059550732,0.06034097,-0.0405595,-0.051526945,0.08752854,0.05251603,0.039891336,0.0654188,-0.0078030853,0.05119028,-0.038137306,-0.0018792631,-0.00089860614,0.03251308,-0.030933362,-0.07919304,0.094082884,-0.006738416,-0.02633969,-0.06234765,0.06826522,0.012398995,0.018582834,0.017173376,0.025440296,0.016194468,0.054830734,0.049257845,0.034465022,-0.05472099,0.032122847,-0.016831536,0.023261052,-0.08691931,0.011993354,-0.013045782,-0.054691095,-0.01397793,-0.002572915,0.030854588,0.107425794,0.007580889,0.04955087,-0.015835484,0.05180437,-0.049712863,0.07369029,0.009057218,-0.002838584,0.037521433,0.008848231,0.00836391,0.0022616372,-0.023358399,-0.034144558,0.07417887,0.042137735,-0.005581248,-0.00470486,-0.10358003,-0.092760995,0.013375296,-0.026528582,0.085448936,0.020802334,-0.055376958,0.040108096,0.037867684,0.029152531,0.066693336,-0.0070916037,-0.05979358,0.04064537,0.025342887,-0.0142293405,-0.12180093,0.010196295,0.009963981,0.03883551,-0.0845477,-0.029873751,0.0069524273,-0.051164225,0.027074063,-0.13695706,0.040324725,0.049128033,-0.018169638,0.033004083,-0.018893937,-0.041703735,-0.029785138,0.020363597,0.031104539,-3.5726895e-08,0.02598275,-0.00913939,0.02089037,-0.07392079,-0.017254826,-0.009708746,0.023410501,0.048085436,0.08791494,-0.004782675,-0.036704235,0.11186185,0.0050391164,0.020701235,0.027759735,0.026153963,-0.040955145,0.01477988,0.023987949,0.061440937,-0.032510813,-0.032065246,-0.12907378,0.026200727,-0.021429919,-0.06483736,0.05344618,0.05190603,-0.020217393,-0.0056572114,-0.049015246,0.041820817,-0.010268562,-0.04210009,-0.1358628,-0.040696047,-0.03177818,-0.07492782,-0.014574837,0.043935224,-0.0041616214,-0.03348346,-0.09814234,-0.057872463,-0.06627306,-0.02351443,-0.033413313,0.041846108,-0.03403655,-0.01819893,-0.0062967245,-0.027666958,-0.035699528,-0.06568896,-0.059233114,-0.050212875,0.005552246,0.010218563,-0.010473394,-0.040573664,0.014682482,-0.02197912,0.18110192,-0.024891458 +4.3.99.5,"The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites.",384,0.99999994,-0.09542155,-0.042598076,-0.085146226,0.043040067,-0.0050594215,0.06406074,0.037753362,0.056291036,0.05715734,-0.016521072,-0.021975419,-0.0534298,-0.0040981565,0.088393636,-0.07295744,0.04296182,-0.06566309,-0.033854432,0.016072877,-0.02284148,0.075586714,0.08830547,-0.017020196,-0.008666753,-0.01759444,-0.019570809,0.015225458,-0.0015400199,0.016322078,-0.0849332,0.025564143,0.05143967,0.030411484,-0.08033354,0.089048244,0.04029897,-0.03156702,-0.03022462,0.041201163,0.016530305,0.026834993,0.019098073,-0.013135264,0.030699022,-0.0028944353,0.02234216,0.047582768,0.050184876,0.05132614,-0.0584878,-0.08315692,-0.057421625,0.016201792,0.076918274,0.06571031,0.0050093285,-0.032261517,-0.060306035,-0.050310694,0.0049389848,0.10907136,0.033258136,-0.021836158,-0.025118489,0.021032674,0.026542492,0.04920882,-0.033878062,0.03923043,-0.09269103,-0.040231295,-0.063067555,-0.044290364,0.02213551,-0.015938586,0.00030912593,0.055006493,-0.0024128272,-0.03460168,-0.013329403,0.018462032,0.06114023,0.027113957,0.06363329,0.028374309,0.031280093,0.026130948,0.034733776,0.02809889,0.064074405,-0.01386466,-0.007854933,-0.0033519103,-0.07664867,-0.063175276,-0.026803464,-0.048396923,0.0043687406,0.061125923,0.014055257,0.04396744,0.04738312,-0.026965383,-0.0342692,-0.041745543,0.004096659,0.035992555,0.04976052,0.05253894,0.05318467,-0.0024149567,0.013124123,0.014315028,0.013869432,-0.02207167,0.03839511,0.055891752,-0.008762208,-0.10045521,0.060886715,-0.0054992484,-0.027303252,-0.038116504,0.016724098,-0.050890666,0.08364195,-0.12845708,-1.0255182e-33,0.09032983,0.015431859,-0.021053102,0.011360893,0.041909542,0.017867122,-0.1097153,-0.04345214,0.0028734433,-0.10364395,-0.10376708,-0.07540033,-0.01142919,0.010887236,0.02402344,0.036472823,-0.07331635,-0.014704894,0.0915847,0.0279557,0.0020590066,0.058882013,-0.08245689,-0.048471577,-0.026987463,0.12890875,-0.037857518,-0.01249071,-0.016738866,-0.04232724,0.029952874,-0.083528414,-0.08188322,0.0535231,0.08191059,-0.013907402,0.015190224,-0.016489835,0.013853031,0.07925269,-0.00816062,0.088935964,-0.0011236588,0.006762989,0.019750366,-0.057884626,-0.09290209,0.1373518,0.11998916,0.0432997,0.02962414,-0.058482967,0.13065109,-0.03994288,-0.047385562,0.05445072,-0.011429237,0.008094373,0.07040274,-0.010036306,0.046291348,0.004532925,-0.0043297326,0.11647086,0.022116907,0.0051319166,-0.06986457,-0.021166673,0.06219928,0.094399795,-0.14153123,0.0034311246,0.030498162,0.0052574524,0.021460254,-0.114089064,-0.06056328,-0.0559725,0.055321157,0.04974361,0.02221051,-0.10101773,-0.0126722595,-0.030244796,-0.04387737,0.007045344,0.0033749226,-0.07694082,-0.021011677,0.02634921,-0.000734776,-0.10013171,-0.11959995,0.017919287,0.02731328,-1.0927441e-33,0.11565609,-0.07768531,0.048816774,-0.05419168,-0.016674982,0.02977178,-0.045821637,-0.088845804,-0.014233076,0.022047177,0.03579345,0.0038616885,0.05364335,0.013933996,0.021274008,-0.041987322,0.058373272,0.026341192,0.0039623543,-0.027239801,-0.062173754,0.030334445,-0.040467244,-0.073969014,0.016363906,-0.017608017,-0.05280613,0.033137564,0.025462834,0.035904903,-0.0023763757,-0.026699053,-0.060490966,-0.12248769,-0.004352413,0.07420656,-0.01372243,0.005257287,0.007133995,-0.052333828,0.047917154,0.038305663,0.093367524,0.113140054,-0.009921376,0.0898968,-0.07693497,-0.025764856,-0.0086946655,-0.022945773,0.07076645,0.0015581927,-0.027161907,-0.0016785988,-0.0103885345,-4.4176337e-05,0.017099388,-0.016938776,-0.04555992,-0.0065514967,-0.03033672,-0.046736814,-0.02987114,-0.04937901,-0.0023556734,0.036844507,-0.0014740345,0.0669891,0.07287896,-0.016247738,0.031280503,0.006708693,0.0715118,0.035140626,-0.08237402,-0.002966855,-0.07403957,-0.077661395,0.018270988,-0.051288046,0.010916723,-0.04599665,-0.0275811,-0.065824986,-0.030127479,-0.05130113,0.059973255,0.11573636,0.013852758,0.011348688,0.0024955869,0.03591475,-0.050809838,0.008047238,-0.06116048,-3.1888128e-08,0.030585032,-0.087945536,0.019079546,0.010624585,-0.026375044,0.01138287,0.018119602,0.0047525815,0.072285764,-0.011537084,0.024057204,0.041165516,-0.023698932,-0.020268356,0.0718252,0.04660005,-0.016105767,0.0024026555,-0.03389564,0.020459391,-0.08801967,-0.0009183883,-0.08501693,0.016294692,0.013049545,-0.082875386,0.0047735292,0.031822596,0.0073319706,-0.008195217,0.0065969992,0.039273106,-0.012573548,-0.011775716,-0.10006395,0.010669052,-0.035585362,-0.034121748,0.01239481,-0.044545464,0.025529305,-0.03926767,-0.08059208,0.002652265,-0.041854806,0.0033943611,-0.08888358,-0.010376932,-0.0036728056,0.011092433,0.028765727,-0.034585502,0.010450037,0.01967278,-0.08576193,0.0777546,0.09237467,-0.053947918,0.016064875,-0.04215199,-0.019562613,0.035313785,0.14035782,-0.004642761 +4.8.1.1,"Contains a heme b cofactor. The enzyme, characterized from the bacterium Kutzneria sp. 744, is one of very few enzymes known to result in the formation of an N-N bond. (3S)-1,2-diazinane-3-carboxylate (piperazate) is known to be incorporated into assorted secondary products that are produced by nonribosomal peptide synthetase or nonribosomal peptide synthetase/polyketide synthase hybrid pathways, such as the kutznerides, padanamides, himastatins, and sanglifehrins.",384,1.0,-0.07162705,-0.04932254,-0.19503932,-0.035928655,-0.02918795,0.05810651,-0.031220093,0.03072815,0.03003147,-0.00124136,-0.045044906,-0.05208803,-0.045888834,0.0637331,-0.08999278,0.05984666,-0.13625321,0.0019717482,-0.02541297,-0.05324896,-0.024244534,0.06995431,0.062195335,0.05560484,0.022233756,0.05639082,0.06230219,-0.051108487,0.05332327,-0.06751735,-0.005791228,0.024940146,0.08319215,-0.06598007,0.11166319,0.00065426744,-0.012585584,-0.09295016,-0.0005035569,0.053120844,0.05999976,0.03619519,-0.04574192,-0.023144204,-0.015310009,0.014067464,-0.0043461705,-0.019551823,0.050051864,-0.04874927,-0.059862293,-0.044687044,0.0031309861,0.06279527,-0.023839597,0.000493755,-0.051990245,-0.0032650658,-0.03181912,0.027648736,0.07181563,0.073238574,0.04554788,-0.0074138534,0.027661448,0.023744393,-0.06401834,-0.06392768,-0.03633249,-0.04132823,-0.037138645,-0.13352992,-0.06358295,0.082465924,0.0019598713,-0.0049357708,0.040011376,0.017308632,-0.048478153,-0.014016867,-0.004805929,-0.032436825,0.014243552,0.10001987,-0.022319302,0.0492626,-0.043660037,0.058812663,0.06048141,0.014933143,-0.041350737,-0.012433447,0.00692309,-0.067139275,-0.05443442,0.0146103995,0.04941386,0.0829109,0.06314942,0.016658051,0.0009966288,-0.007907936,-0.060090594,-0.029139413,-0.06127896,-0.0022707714,0.034681022,0.07570904,0.049864095,0.024433544,0.003139274,0.037653662,0.059180677,-0.01519919,-0.029003333,0.019151002,0.07362958,-0.034616336,0.045336954,0.040463857,0.056817442,-0.01019764,0.036188442,0.005382509,-0.0122505445,0.025339553,-0.15934093,3.6688872e-33,0.06737526,0.01371124,0.087616436,0.019453498,-0.05030129,-0.029267557,-0.09709491,-0.032118734,-0.025413716,-0.068229645,-0.071921416,-0.04238194,0.09794527,-0.019889817,0.04665713,0.007130532,-0.100762255,0.014715803,0.05774247,0.011207628,0.031972434,0.07540124,-0.08348095,0.063292645,-0.009189181,0.039277658,0.11159832,-0.028659567,0.014971073,-0.049377847,-0.024666606,-0.038743336,-0.05381594,-0.038150392,0.0077758543,0.009364456,-0.02216347,-0.020475406,-0.065665066,0.09957455,-0.012412827,-0.051775884,-0.035700355,-0.032628734,0.07617469,-0.08642962,-0.044840828,0.047962807,0.055750024,0.03533662,0.028867513,-0.014201633,0.08493182,0.066413954,-0.040979397,0.09709411,-0.020278104,-0.04175149,0.09264237,0.0057921363,-0.037827954,-0.029740369,-0.0711363,0.0045546633,-0.0058521875,0.017849416,-0.06878339,-0.014153973,0.010475426,0.079796895,-0.051381256,-0.029080344,-0.01618588,0.031774886,0.06655311,-0.07159097,-0.087984964,0.0026893169,0.035548348,0.012848361,0.018683655,0.00046178306,0.041098963,0.04205032,-0.08894931,-0.050340377,-0.026277928,-0.011780406,-0.06762348,0.089923486,0.011357003,-0.096421935,-0.054388124,0.024189321,-0.013459818,-4.3141275e-33,0.11033044,-0.07148707,0.018384166,-0.03657904,0.011884021,-0.0052581634,-0.033623267,-0.0012262467,-0.0011815107,-0.06587548,0.09515224,0.031131003,0.07215578,-0.027900787,-0.021357862,0.021704966,0.025984982,0.03657751,0.0042374698,-0.010078596,-0.00987029,0.052249763,-0.03836715,-0.0075455788,-0.039964184,0.009609204,-0.013145267,0.080336764,0.022410514,0.07013898,0.02105038,-0.03192271,-0.015984932,-0.055832896,-0.030592153,0.08683256,-0.014188612,-0.012782562,-0.004639755,-0.060709413,-0.052039973,0.02512435,0.06539653,0.064465016,0.05569432,0.08792593,-0.05847917,0.006773934,0.006177496,0.003493526,-0.0047843866,0.010090935,-0.05028541,-0.010811828,0.013851362,0.0024467434,0.021478018,-0.0024104705,-0.00594914,0.02543545,0.03747182,-0.03382045,0.07156043,0.012693608,0.027204208,-0.04440592,-0.06459183,0.10540618,0.086871676,-0.017320817,0.05839818,0.055397745,0.055966504,0.11883906,-0.020763459,-0.048054144,-0.042062998,-0.02695378,0.060030196,-0.039948095,-0.02288672,-0.03299433,0.02249768,-0.047815353,-0.004063655,-0.015070236,0.039455954,0.04710375,0.012671474,0.005176559,-0.037034433,-0.0056720898,-0.06356895,0.09113884,0.013064964,-4.864503e-08,0.047850024,-0.107660145,-0.07024158,-0.031000575,-0.043417297,0.043483414,-0.026670896,-0.04054036,0.06637103,-0.07962504,0.02940028,0.0057968176,-0.040689252,0.06624355,0.048387535,0.017716235,-0.017866641,-0.027077684,-0.033949595,-0.019577416,-0.06979067,0.040130537,-0.066847846,-0.014662822,-0.011406809,-0.026775077,-0.037648376,0.061238322,0.009082712,0.01849253,-0.030821366,0.05370112,0.039217282,0.0003285796,0.002430865,0.006319796,-0.03289988,-0.005040528,0.014576915,-0.0036665464,0.023729138,-0.037654437,-0.10092107,0.0018860768,-0.02908398,-0.01314573,-0.048899826,0.005415932,-0.037415236,-0.083803415,0.09146915,-0.02553729,0.012981523,-0.013270433,-0.070148036,0.028011937,0.0025106382,-0.055442307,0.050256934,-0.09415765,-0.028123498,-0.02849576,0.1938808,0.050062604 +4.8.1.2,"The enzyme from Pseudomonas chlororaphis contains Ca2+ and protoheme IX, the iron of which must be in the form iron(II) for activity. The enzyme exhibits a strong preference for aliphatic aldoximes, such as butyraldoxime and acetaldoxime, over aromatic aldoximes, such as pyridine-2-aldoxime, which is a poor substrate. No activity was found with the aromatic aldoximes benzaldoxime and pyridine-4-aldoxime.",384,1.0,-0.011565643,-0.06642671,-0.036778733,0.050918765,0.060093954,0.0800314,-0.039192226,0.02283146,0.014587568,-0.012395278,0.03019574,-0.10295212,-0.0073512304,0.09268783,-0.053533856,0.0007043238,-0.031019518,-0.0015110495,0.04185613,0.054350145,0.032091696,0.018061513,-0.06622053,0.031420916,0.006547799,0.07602979,0.049574845,-0.014929596,-0.0054310244,-0.015494886,-0.09059087,-0.04267219,0.10238211,-0.083675124,0.0550179,0.079220705,-0.060724795,-0.03368743,0.045978274,-0.0036802248,0.010794971,0.006416876,-0.027137289,-0.009962888,-0.018243095,-0.025242131,0.110079,-0.04828667,0.08484903,0.02591599,-0.0463796,0.008908806,0.016309865,0.08550689,-0.026075326,0.03466389,0.021623459,-0.0059776637,-0.04682269,0.00028572048,0.035099167,-0.04495713,-0.032517575,-0.029440545,-0.018909004,0.0058865673,0.027830373,0.008323731,0.015091207,-0.07873272,-0.016975451,-0.010871454,-0.023711665,0.012350952,0.052113168,-0.0150543535,0.006513261,-0.13125908,-0.005263086,-0.0708613,-0.004330814,0.00026628101,0.047022462,0.08101398,0.09479196,0.030592477,0.009555269,0.0032911873,0.02792828,-0.011351456,0.022012034,0.031269815,-0.058904067,-0.05740417,0.023171848,0.08811456,0.00440381,0.052838583,0.0034450248,-0.06769608,0.028149841,0.023810217,-0.07677821,-0.08976991,0.047973793,0.057351474,-0.02169861,0.06414318,0.014108681,0.021490736,0.039308794,-0.0044266167,0.023040278,-0.071153566,0.04629619,0.10088275,0.09472018,-0.022645487,-0.08636865,0.05844982,0.025648765,-0.08222686,0.0006551031,0.045022003,-0.00827629,-0.019496404,-0.09616415,4.466329e-33,0.051386155,0.051767554,-0.017673267,0.0018616853,0.015761826,-0.0020929952,-0.07913063,-0.0076259812,-0.041758083,-0.12116566,-0.011249659,-0.03430262,-0.051105518,0.026056586,0.0064030825,-0.004650953,-0.027273024,-0.058856655,0.12012447,-0.014061107,0.02548256,0.0012882702,-0.04241125,0.032418225,0.05594919,0.066354915,0.046670213,0.027439022,-0.07193807,-0.010965068,0.0324761,-0.05747344,-0.11838771,0.00024566008,0.061326787,0.047111366,-0.02785393,0.010385282,-0.078358,0.07717776,-0.004574305,0.051966205,-0.016277459,-0.049001563,0.06743025,-0.10500443,-0.08133601,0.111091636,0.02529019,0.1358931,0.0036086536,-0.026135216,0.07241096,0.034676593,-0.08989706,0.02173037,-0.024015386,-0.028155675,0.006652192,0.03846228,0.09276521,0.02684748,-0.017094897,0.08195419,-0.03735912,-0.03806805,-0.050856184,0.014653004,0.02802993,0.04846433,-0.09118552,0.03630873,0.006400747,0.024896024,0.050221026,-0.10715182,-0.08340137,-0.00011146569,0.059870154,0.01685715,0.025273727,-0.06435312,0.08152439,0.005700038,-0.13236806,0.01657689,0.017868426,0.013155278,-0.0104556335,-0.04167399,0.00084790814,-0.061199676,-0.0519514,0.040850744,-0.043972563,-4.7654445e-33,0.073297165,-0.11312574,0.1257241,-0.060774088,-0.09027869,0.023070566,-0.02112733,-0.0018591898,-0.0122874845,0.016165843,0.13831194,0.04320852,-0.0413614,-0.025013437,0.060300887,0.060208827,0.0034604284,0.032038864,0.015607766,-0.034031615,-0.0043486697,0.053476054,-0.06788759,0.029156445,0.08826883,-0.008420496,-0.041435827,0.015720151,0.067108735,0.089239515,-0.0069251317,0.036845624,-0.041529752,-0.050082717,0.009712333,0.028604364,-0.068341345,0.027877996,-0.008606498,0.08978495,0.042412832,-0.021953553,0.04458409,0.046040818,-0.015436202,0.004996659,-0.04609307,-0.0433527,0.044108946,-0.08495488,0.03255855,-0.0136127,-0.052109655,0.016089266,0.057371277,0.016561775,-0.0062489584,0.03584227,-0.026210431,-0.041347876,-0.06595098,-0.0414701,-0.008169767,-0.060723584,0.023095403,0.049761545,-0.021998307,0.02394465,0.041886657,0.023696257,0.030729236,-0.022307765,0.026247572,0.003582363,-0.1291095,-0.00017877932,-0.02472596,0.05809543,0.004199255,0.028445391,0.06728149,-0.019022338,0.01473785,-0.036636684,-0.0074114506,-0.05047674,-0.010967368,0.081300795,-0.08089716,0.004692114,-0.050695788,0.0023388322,0.022934465,-0.00916855,0.006249913,-4.4998593e-08,-0.016266586,-0.018032834,-0.003849836,-0.035257783,-0.036831357,0.019730866,-0.0015262173,-0.056401964,0.009757552,0.029810414,-0.05308757,0.035422772,0.013174253,0.020551939,0.006182589,0.007091489,-0.033994764,0.013434892,-0.010803989,-0.008748497,-0.11212201,-0.01516358,-0.13900685,-0.02426906,-0.02834486,0.005307705,0.06418659,-0.051526085,0.044522766,0.027947305,-0.040242456,-0.012656099,-0.029460747,-0.03705031,-0.062611386,0.0068272566,-0.038245395,-0.046625372,-0.09919703,-0.0032610255,0.06921577,-0.08996083,-0.074261144,0.00980863,0.111873,0.009571203,0.03610048,-0.0020530664,0.0038445492,-0.050899677,0.10906135,-0.026747365,0.025066784,-0.015690913,-0.09531669,0.10911448,0.055698268,-0.04129882,-0.04092223,-0.053574894,-0.003395243,-0.001452897,0.10468132,0.007106819 +4.8.1.4,"The enzyme from Bacillus sp. OxB-1 contains protoheme IX, the iron of which must be in the form iron(II) for activity. (Z)-Phenylacetaldoxime binds to ferric heme (the iron(III) form) via the oxygen atom whereas it binds to the active ferrous form via the nitrogen atom. In this way, the oxidation state of the heme controls the coordination stucture of the substrate---heme complex, which regulates enzyme activity [2]. The enzyme is active towards several (Z)-arylacetaldoximes and (E/Z)-alkylaldoximes as well as towards arylalkylaldoximes such as 3-phenylpropionaldoxime and 4-phenylbutyraldoxime. However, it is inactive with phenylacetaldoximes that have a substituent group at an alpha-site of an oxime group, for example, with (E/Z)-2-phenylpropionaldoxime and (E/Z)-mandelaldoxime. The activity of the enzyme is inhibited completely by the heavy-metal cations Cu+, Cu2+, Ag+ and Hg+ whereas Fe2+ and Sn2+ have an activatory effect.",384,1.0,-0.054441903,-0.099628106,-0.059643973,0.056487355,0.10227904,0.014490005,-0.0058262097,0.032122277,-0.0081032,-0.054235216,-0.022737226,-0.015216945,0.065386236,0.066171475,-0.045678947,0.0346697,-0.1093901,-0.0067384285,0.0014973158,0.031011581,0.036746085,0.05785512,0.004096445,0.0009839778,-0.05824574,-0.03464252,0.09557387,-0.044650517,-0.055998996,-0.051442716,0.012921487,-0.025306752,0.10208017,-0.028918697,0.047340706,0.016022071,0.008949924,-0.06944147,0.028479433,-0.0008312084,0.010475115,0.049828734,-0.05565835,-0.08156983,-0.06527799,0.004528162,0.11331591,-0.058501717,-0.036409397,0.07804342,-0.05008212,-0.023809077,-0.03523136,0.0918919,-0.009281172,-0.008366203,-0.028555455,0.004423372,-0.03421113,0.015726617,0.011600072,-0.042163838,0.013819792,-0.02167624,-0.00864904,-0.026512697,0.08623538,-0.06920923,-0.08732847,-0.07097019,-0.07591548,-0.00926712,-0.03609934,0.03562135,0.01307774,0.035938576,0.0312799,-0.08021499,0.053338915,-0.066692814,-0.02617211,0.017016718,0.06415522,0.13142318,0.055303466,0.03505086,-0.045951806,-0.016292704,0.040892847,0.049188826,0.019744694,0.059989177,-0.062460147,-0.003128582,0.035283446,0.013454904,0.039238922,0.07101573,-0.009982148,0.010899289,-0.031293694,0.049682155,-0.022048969,-0.022732712,0.05797539,0.0085407365,0.019803526,0.051446903,0.025177492,0.07758007,0.062169578,-0.022390403,0.13442245,-0.05812344,-0.022549704,0.08480643,0.013020722,0.0012693275,-0.070023045,-0.044995386,0.049096856,0.012794352,0.074186,0.02037519,-0.031217635,-0.0266193,-0.068928294,5.0465155e-33,0.021152472,0.020333732,-0.011043429,0.03742619,-0.019411208,-0.008532051,-0.08811858,0.029755032,-0.0027599637,-0.009613496,-0.07901741,-0.04917065,0.07222954,0.0070137302,-0.015514187,-0.027066087,0.0073615257,-0.021139164,0.021720361,0.046441417,0.08782111,-0.05823973,-0.014848523,0.010790092,0.0061328006,0.03286195,0.02880957,0.0014377005,-0.034125976,-0.027294677,0.05724093,-0.12273395,-0.11221834,-0.06797518,0.050059192,-0.016484005,-0.026893508,0.025516897,-0.11163846,0.039247084,-0.03808143,0.030282965,-0.07068398,-0.0070635746,0.0805137,-0.08589077,-0.056523174,0.14837612,0.02484933,0.07342157,0.009013844,-0.046929277,0.110270455,-0.030160943,-0.04601462,0.04454623,-0.024162801,0.0048124287,0.077618726,0.04398279,0.11314563,0.012918502,0.008295415,0.09738661,0.016948197,0.07826779,-0.05875895,-0.04202733,0.01390772,0.048673708,-0.04495525,0.06375146,0.06328273,-0.015389138,-0.018438049,-0.05273082,-0.048191503,-0.024072113,0.052441943,0.0035317084,0.0020700812,-0.0918654,0.043487232,-0.025029175,-0.084011644,-0.063361086,-0.034273066,-0.0004043729,-0.047840927,-0.012128764,0.09318388,-0.09123768,-0.07523337,-0.011590609,0.005716735,-4.4058234e-33,0.122130334,-0.06860221,0.05107555,-0.13742283,-0.04318359,0.01717338,0.05183562,0.0047018826,-0.036517363,-0.059754618,0.06710827,0.046207752,-0.043251656,-0.030856205,0.034711402,0.07423858,-0.024841463,0.060864545,0.0842839,-0.010989706,-0.013395695,0.054628305,-0.040617708,0.012111399,0.027655577,0.007759391,-0.041354783,0.019452613,0.06105851,0.06308917,-0.019755702,0.024522433,-0.0062434,-0.05386216,-0.071623534,0.086608015,-0.046824597,-0.029708104,0.028579697,0.007995999,0.008917456,-0.02045471,-0.038031176,0.05846914,0.0663642,0.09674138,-0.12234073,-0.0133337155,0.007954558,-0.05456658,-0.0033101575,0.022334073,-0.017965704,-0.05661663,0.094421655,0.038533047,0.007101579,0.011718378,-0.06002403,-0.05112342,-0.029270973,0.018007515,0.081325285,0.03908566,-0.027908575,0.0734517,-0.010132396,0.057928223,0.09109651,-0.039076377,0.03452928,0.014263438,0.02861896,-0.028030014,-0.003994024,-0.01676575,-0.0027658208,0.042060237,-0.024569094,0.033880163,-0.021864977,0.0019394471,-0.046389975,-0.017157622,-0.007858297,0.009653315,-0.03884833,0.064715095,0.019521302,-0.0467765,-0.09309641,-0.0051479274,0.0022974212,-0.015700225,0.00091006217,-5.0612144e-08,0.014014813,-0.05760694,0.02823417,-0.052065324,0.005546416,0.007896997,0.01916499,-0.03870954,-0.006535144,-0.024543902,-0.007181961,0.103059396,-0.02707095,-0.036574334,0.07640213,0.01910278,-0.05744701,-0.0127713615,-0.035754114,-0.005227779,-0.029165054,0.01578513,-0.073885694,0.07311694,0.03526379,-0.09371572,0.0061925678,-0.04396402,-0.013915514,-0.017376984,-0.016410422,0.023614274,0.00032311853,-0.018343829,-0.062353272,-0.0037460811,-0.054717094,0.007444107,-0.037394904,0.057867516,-0.020671325,-0.03850397,-0.053677693,-0.05038378,0.07454612,0.065071985,-0.04271167,0.01227152,0.036463387,-0.087669164,0.005563449,0.032990366,-0.034781903,0.021242846,-0.096813,0.120505236,0.03316836,-0.059146814,0.044338424,-0.01614202,0.006098011,-0.0021863168,0.120464474,-0.06174176 +4.98.1.1,The enzyme catalyses the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria. The reaction is catalysed only in the reverse direction.,384,1.0,-0.064660095,0.02343532,-0.06459045,-0.00128323,0.014244812,0.02609715,-0.08780033,0.08884567,0.032853067,0.05128385,0.0041728704,-0.05662284,-0.04984656,0.015568271,-0.046685126,0.016988257,-0.12302052,0.058431536,-0.03769333,-0.081537776,0.05207672,0.051629078,-0.05788809,0.0068500773,0.014779536,-0.0321109,0.0829983,-0.039960142,-0.012659241,-0.08569833,-0.010095769,-0.04478709,0.07770853,-0.052512757,0.058908444,0.051292982,0.015807703,-0.09992665,0.0704407,-0.008747952,0.07028911,-0.01473449,-0.08634961,-0.041938517,-0.053919777,0.043006502,0.0671598,-0.02025111,-0.0045719515,-0.02103575,-0.028256891,0.014102292,-0.107085966,0.022612339,-0.010055421,0.024221795,0.04515236,0.014724042,0.05669343,-0.027965114,0.012251155,-0.030742172,-0.063151404,0.0052841115,0.00018710496,-0.12196781,0.040369224,0.00024846257,-0.0565868,0.022847546,-0.011176843,-0.09003203,-0.06367052,-0.0058033043,-0.027859885,0.0644628,0.009963123,0.0071042534,-0.0049171075,0.00041888747,0.03765867,0.01744866,0.06324833,0.12857732,0.0027632609,0.00040250193,-0.027293336,-0.0025045064,0.079605736,0.04780298,-0.023401324,-0.039603543,0.028827628,-0.071422145,-0.04842079,0.04351707,0.052019946,0.060666207,0.088426955,-0.012667801,-0.004806962,0.059424847,-0.003537251,-0.04365304,-0.0063882708,-0.002958825,0.0036945469,0.11406795,0.11403239,-0.009319898,0.005508505,-0.021903066,0.11081358,-0.014978123,-0.07741086,0.07675661,0.021469353,-0.039734147,-0.045859702,-0.0047410666,-0.009626323,0.009574208,0.03725807,0.045875385,-0.04814077,0.014761522,-0.09580461,3.8053884e-34,0.054930247,0.037130874,0.029916426,-0.06878157,-0.04152907,-0.022844791,-0.11975756,-0.023469752,-0.018944247,0.018558826,-0.0325901,-0.08475965,0.038297176,-0.019356057,-0.05898407,-0.03736961,-0.0025800553,-0.019226639,-0.038946252,0.053489987,-0.008551868,-0.044292733,-0.022104917,-0.046677314,0.05102508,0.04463433,0.030836057,-0.028706685,-0.0030120565,-0.0020753338,-0.03231028,-0.05974995,-0.06255396,-0.03285161,0.06722614,-0.03498119,-0.011497151,-0.0022885685,-0.022838589,0.038891256,-0.022287779,0.07911388,-0.04599273,-0.07359925,0.065175,-0.024949076,0.011405114,0.024747875,0.046724066,0.12383865,0.0020824804,-0.014168358,0.12895821,-0.0044641015,-0.011109232,-0.0068995566,-0.031278975,0.002087939,0.07607643,0.05140391,0.0498797,0.050246973,-0.0491204,0.011169443,0.031325083,0.037635706,-0.061016075,-0.028257841,0.05210132,0.053479414,-0.10447921,0.0046229716,0.039974872,-0.0101852985,0.0008057987,-0.034467906,-0.06901956,-0.016960384,0.062084924,-0.05672151,-0.01969723,-0.0014731131,-0.01292587,-0.037522968,0.037215136,-0.020351432,-0.058132514,-0.038000148,-0.108439796,0.02537869,0.070972465,-0.096482545,-0.045322105,0.06149107,0.015273272,-1.9435159e-33,0.107985616,-0.05508937,-0.0446284,-0.13388102,-0.07161553,0.057957668,-0.011436618,-0.02572714,-0.001439442,0.034036517,0.041137554,0.04836506,-0.017957548,0.052979086,0.027801191,-0.012193926,0.06639829,0.07130733,-0.017071648,-0.025116837,0.00023554894,0.04352502,-0.037232168,-0.00073046586,0.045350973,-0.022004943,0.0010248952,0.123138055,0.022303125,0.044129763,0.016810365,0.009653778,-0.037902277,-0.0134004615,-0.036436483,0.047073033,-0.0025782026,0.052439705,0.08833042,-0.037916142,0.02570901,0.0019647423,0.058152568,0.061388027,0.010165662,0.07160616,-0.101528995,0.070676886,-0.013834897,-0.059764925,0.016886596,0.03990123,-0.013352876,-0.009571398,-0.00772532,-0.017793756,0.043446034,-0.004541994,-0.054897357,-0.035267916,-0.074144065,-0.01393036,0.098617576,-0.02693501,-0.007877573,0.066883884,-0.06976221,0.05080397,0.038159866,-0.045592938,0.051008824,0.0745711,-0.010163677,-0.0003098405,0.043506566,-0.05390285,-0.028238822,-0.072533675,0.068722494,-0.026272956,-0.048305154,0.0066015837,-0.005822722,-0.11290417,-0.014656959,-0.07351381,-0.016518965,0.09471555,-0.036372524,0.0048478935,-0.03527101,-0.05157943,0.04065595,0.053012736,0.060949985,-2.7782361e-08,-0.060813963,-0.08868743,0.035882775,0.017709706,-0.0014540611,0.089252636,-0.0027540328,0.075661026,0.06133577,-0.0035262236,0.020069098,0.06476596,0.0058033853,0.015771298,0.05912703,0.09280568,-0.037342668,-0.018453222,-0.022207737,-0.013075894,-0.012877327,-0.006050564,-0.067017585,0.09025566,0.050951388,-0.111591265,0.008536518,-0.018938372,-0.016180072,-0.045700133,0.012065409,0.0511455,-0.046100736,0.0166477,-0.015239401,-0.041561306,-0.0025978643,-0.006968276,0.040626485,-0.045388404,0.049992558,0.0014641072,-0.11046152,-0.024825726,-0.034052417,0.091534354,0.04224778,0.053568628,-0.069015115,-0.05084742,0.052435737,-0.020669533,0.01893749,-0.001909805,-0.088053115,-0.024597863,0.007971785,-0.06368272,-0.013269104,0.029176766,0.048574653,0.04497111,0.17175165,-0.06489776 +5.3.99.12,"The enzyme is responsible for production of the irritating lachrymatory factor that is released by onions and related species when they are chopped. It acts on the product of EC 4.4.1.4, alliin lyase. The enzyme from Allium cepa (onion) acts on (E)-prop-1-en-1-SO-peroxol and produces (Z)-propanethial oxide, while the enzyme from Allium siculum (honey garlic) acts on (E)-but-1-en-1-SO-peroxol and produces (Z)-butanethial oxide.",384,1.0,-0.033709686,-0.050239597,-0.032052524,0.013712509,0.11235762,0.08535185,-0.08122945,0.029580874,0.04725855,-0.018525157,0.16271584,-0.075276025,-0.062118206,-0.01837231,-0.028372226,0.03828374,-0.0027663724,-0.00044463636,-0.070084035,-0.0999331,0.0879876,0.023283275,0.004665799,-0.02712093,0.06686336,-0.037532207,0.025246518,-0.05709608,0.010721599,-0.08039273,0.018930689,-0.0357388,-0.012121138,0.014050984,-0.023069628,0.035956908,-0.070538305,-0.10890837,0.019887898,-0.0020137562,0.0412706,-0.05590605,-0.037463937,-0.104826294,-0.013327399,-0.004396788,0.0035104153,0.06799906,0.005901315,-0.07290783,-0.012333121,-0.0790439,-0.008161669,-0.04003364,0.0014964408,0.009952649,-0.020027796,0.016353825,-0.036133878,0.042689968,0.010111786,0.019125493,-0.02104319,0.055040378,0.007565699,0.011510895,0.06904468,-0.06906269,-0.07625456,-0.041742243,-0.030062493,-0.07727488,0.022498924,0.04791573,0.12546423,0.028412407,-0.056353077,-0.041958597,0.018408222,0.0067254524,0.019633498,0.030304559,-0.02665262,0.048617043,0.0039913175,0.04386522,0.021424642,-0.0043025487,0.020645283,0.030790403,0.07332272,-0.062886275,-0.0899267,0.027098596,-0.00684078,0.10888192,0.036313135,-0.01615328,0.022903034,-0.05677651,-0.04188802,0.012090456,-0.06364832,-0.08884686,-0.02887893,0.0569847,0.07377006,-0.01709708,0.003300867,-0.01878912,0.019566232,-0.013695887,0.005801646,-0.042135168,-0.041982587,-0.0006485715,0.09098023,-0.04894205,-0.016909717,0.017690808,-0.044857588,-0.01748262,-0.031976286,0.12473889,0.0031375128,0.07045214,-0.06255362,-5.2104076e-34,0.054456342,0.026367888,-0.03830132,-0.06424255,0.021870216,0.02934997,-0.050307672,0.026558992,-0.02499909,0.007847828,-0.0931698,-0.036830097,-0.022471687,-0.047162548,0.004599217,0.004151277,0.049755495,-0.03386698,0.06183052,-0.00664972,-0.028376037,3.3740045e-05,-0.08129246,0.051929843,-0.038074896,0.07168052,0.023916455,-0.027827566,-0.046605516,-0.01590477,-0.008459354,-0.066746995,-0.060278453,4.6443158e-05,0.009180642,0.04050718,-0.06368245,-0.034809817,-0.047117617,-0.028921867,-0.0120725185,0.111218564,-0.04032708,0.0010118457,0.0017870071,-0.0455884,-0.114406265,0.10096877,0.07995225,0.03475012,0.06578296,-0.00697849,0.11860939,-0.03518945,-0.036198918,0.058133874,0.013269831,0.032312322,0.017737323,0.072951525,-0.032036465,0.044536933,-0.06517326,0.024017215,0.017866656,0.03116783,-0.02903502,-0.03601393,-0.03064911,-0.04732187,-0.07787343,-0.066318065,0.01746098,0.026980272,-0.01624446,-0.050045826,-0.075397134,0.016277213,0.076254115,-0.01177267,2.093825e-05,0.011921845,0.060539853,-0.033620298,-0.024865823,-0.00016668,-0.10489195,-0.0027729936,0.07102248,0.07344336,0.12676619,-0.026284603,0.030592483,0.043543655,-0.03595663,-7.151248e-34,0.0052046874,-0.07376342,0.023571242,-0.020693813,0.0282527,0.04589524,-0.07807399,-0.0118159205,0.0405964,0.032692898,0.075378716,-0.042206988,0.04883355,-0.078678995,0.03996238,0.10117349,-0.024892135,0.08302218,-0.0031350402,0.041559137,-0.03383931,0.09773883,0.07916653,0.018091202,0.06454005,-0.010116362,0.044312753,0.11319626,0.027995147,0.0146854045,0.043834176,-0.03754704,-0.052060336,-0.03732989,-0.021409178,-0.0041964073,-0.052275077,0.06257009,0.082194276,0.0031851016,-0.0010584312,-0.016659426,-0.013407103,0.05368085,0.050950583,0.057390902,-0.03504322,-0.0610657,-0.041738838,-0.03014459,0.00059144263,0.024701608,0.035938136,0.0109226,0.0009807207,0.10578528,0.058901854,-0.010411877,0.0019929651,-0.06130553,-0.020308414,-0.03058609,0.037988525,0.035473935,0.018632377,0.03952305,-0.066334225,-0.006285218,0.051032413,-0.049628437,0.030716617,-0.009580951,-0.09708258,-0.02581941,-0.110116154,-0.017217107,-0.049333557,-0.047378775,-0.010206227,0.00060644717,-0.029657468,0.03942723,-0.016415568,-0.061460234,-0.020245569,-0.08615954,0.059854843,0.14255054,0.029413158,0.047799826,-0.050181814,0.030227607,-0.051671688,0.03314775,0.117524035,-4.021741e-08,-0.023036677,-0.04284114,0.029750098,0.0078348555,0.0245615,-0.08358794,0.071148746,0.046309616,0.019619415,-0.008876197,-0.019010343,0.0936185,-0.039976954,-0.010931246,0.09991943,0.025418717,0.015321355,0.03215397,-0.028138464,0.024133122,0.014330565,-0.046071567,-0.034933,-0.0034244338,0.028181102,-0.08799176,0.037679616,0.0827873,0.028698824,-0.0033296559,0.016683716,-0.010097224,-0.00733206,-0.04404287,-0.100424014,0.05577014,0.0022645625,-0.06656709,0.033098098,0.052852523,-0.06788027,-0.053194217,-0.022145407,0.0029929676,-0.041069835,0.015780706,0.0487166,-0.011517757,0.038514964,0.054179687,-0.006314937,-0.102126375,-0.035498668,-0.036616903,-0.04448698,-0.017473718,0.08772561,0.006153712,0.06612941,-0.06589779,0.0424677,0.026601931,0.1557976,-0.03365191 +5.6.2.3,"The activity is stimulated by DNA polymerase III. As the lagging ssDNA is created, it becomes coated with S Single-Stranded DNA Binding protein (SSB). Once every 500-2000 nucleotides, primase is stimulated by DnaB helicase to synthesize a primer at the replication fork. This primer is elongated by the lagging strand half of DNA polymerase III holoenzyme.",384,0.99999994,-0.074204266,-0.06568109,-0.060628746,-0.01080634,-0.00063273124,0.067292415,-0.04633224,0.07393303,-0.04381463,-0.013602191,0.06510717,0.1285195,-0.040637672,-0.04456271,-0.0059847697,0.042640544,-0.065682985,0.032456838,-0.0064921747,-0.08808058,0.058349997,-0.030959006,-0.03792547,0.02010473,0.002089908,-0.016265366,0.007285144,-0.08242941,0.021861289,-0.053000018,0.01737477,-0.06684511,0.039365698,0.013334812,0.05029307,-0.023615722,0.030132405,-0.027320338,-0.019012311,-0.053692058,0.17830987,-0.054284308,-0.049699504,0.04387569,-0.07545527,0.024335224,-0.03537204,0.040962692,-0.04630173,-0.03857732,-0.039024003,-0.06280039,0.0061163814,-0.013488955,-0.026484303,0.11805772,0.021769254,-0.057777014,0.07736381,0.02926973,-0.010837936,0.018338129,-0.007930184,0.03795277,0.21770366,-0.010616899,0.12045061,-0.016296979,-0.040927153,-0.0012769081,0.025889734,-0.0070935437,-0.055025026,0.07265851,0.04473261,-0.048628163,-0.08824356,-0.04011287,0.028569626,0.021433525,-0.07377876,-0.077488035,0.053696707,0.09815715,-0.04909024,-0.0014765481,0.033067867,0.031172108,-0.05144537,0.06934434,-0.0013987209,-0.041417465,-0.07518287,-0.02601812,-0.09643165,0.057356164,-0.00014903698,0.02177673,0.054480236,-0.06989461,0.027095163,0.00800328,-0.039804,-0.050634425,-0.04081456,0.034453537,0.0073090293,-0.011335144,0.045880374,0.08254911,-0.009687596,0.026245214,0.033498596,-0.05176811,-0.10181365,0.03592015,0.029347973,0.017729918,0.00554073,-0.10871453,0.04317741,0.037309237,-0.02840833,0.029537207,-0.017957503,0.00905834,-0.025992028,3.225051e-33,0.04326122,-0.0015125318,0.039927244,0.02502229,-0.10586729,0.005554294,-0.024626777,-0.013744875,-0.11756908,0.0071774614,0.016677825,-0.07322169,0.05780523,0.014800334,-0.083668225,-0.05100354,0.051984772,0.051943935,-0.004863272,-0.034062825,0.013620844,0.03459216,-0.010310177,0.01396838,0.07733878,0.006273809,-0.030716931,-0.024606174,0.060454838,0.018150726,0.0074486956,-0.050643705,-0.07286565,0.042855136,0.045465462,-0.062380355,0.08087403,-0.07764484,-0.00042525664,0.058002856,0.0048690187,-0.018652271,0.017159186,-0.039784938,0.027776672,-0.0660754,0.02690616,0.03511984,-0.069840685,0.03219385,0.009340744,-0.05132091,0.015079433,0.0047014174,0.0057728654,0.040718738,0.01246725,-0.036305208,0.027702114,0.04386532,0.05329982,-0.0030429338,-0.060871758,0.027710173,0.12039417,0.10335606,-0.0050182245,-0.035943586,0.022092829,0.06759544,-0.029483404,-0.032990985,0.039820258,-0.008042438,-0.004886814,0.022159427,-0.053318262,0.011259989,0.03765956,0.04589391,-0.03795984,-0.06532702,-0.0599961,0.007747489,-0.053094726,-0.058265943,-0.011743992,-0.036449708,-0.04159343,0.020136537,0.111106396,-0.08771576,0.037076913,0.0017941287,-0.028978733,-4.0754756e-33,0.09155997,-0.10348087,0.07550871,0.042687904,-0.0042734165,-0.05711294,0.009017473,0.018654605,-0.02234018,-0.010117813,0.08425114,-0.055906426,0.031719916,-0.048945356,-0.013671765,0.06265856,0.07601731,0.059389696,-0.014281438,-0.020666583,0.01562633,0.093176216,0.055411078,0.13470624,0.02646914,-0.05866241,-0.031734947,0.10615449,0.030859098,0.06473201,-0.027239298,0.03501469,-0.0014206554,-0.06404688,-0.09257727,0.10141355,0.06325024,0.056409296,0.033682853,-0.07250715,-0.034499627,0.028728789,-0.03609904,0.043147154,0.02636895,0.09761771,-0.039001342,0.07936993,-0.017901938,0.029817885,0.04559875,0.0002942253,-0.0061285575,-0.016501294,-0.018185152,-0.041254193,-0.02949717,-0.05525867,-0.02718718,-0.039531477,0.059883893,-0.018752374,0.012114935,-0.013408434,0.016334333,0.017726414,-0.0375071,0.033764336,-0.008105293,-0.07281228,0.043717716,0.05811442,-0.013824979,0.00362645,-0.017258672,-0.0010881192,-0.0591197,-0.011070532,0.02330589,-0.008461415,-0.07606061,0.025521966,-0.020016275,-0.08281046,0.060073324,0.038804986,0.027049262,0.07621194,-0.00487837,-0.040497195,-0.10582212,0.0028566478,-0.035347085,0.09826854,-0.008797444,-3.585634e-08,0.01831603,0.0025855703,0.06835986,-0.037114035,0.030788234,0.024186706,0.022580096,0.04855433,0.071429975,-0.032492522,-0.067982994,0.054224152,0.011870288,-0.037001286,0.13162988,-0.02727901,-0.022390166,-0.036454417,-0.06668917,-0.0746454,0.023421403,-0.004380344,-0.041920677,-0.0013536585,-0.059708092,0.024683345,0.0888126,0.05044576,0.032855615,-0.07555995,0.019842157,-0.008760713,-0.06089636,-0.008463326,-0.036693964,0.054939024,0.04503925,-0.012751384,0.03483087,0.020074284,-0.009620784,-0.009860274,-0.090623446,0.01786985,-0.08127848,0.0070179245,0.011846264,0.014595231,-0.030316714,-0.05910387,0.008527576,-0.0889928,-0.03661516,-0.020158423,-0.007713421,-0.021762494,0.032520227,-0.0034411382,0.004015266,0.006222459,0.055488914,-0.051188186,0.10360605,-0.020190924 +5.6.2.4,"Helicases are motor proteins that can transiently catalyse the unwinding of energetically stable duplex DNA or RNA molecules by using ATP hydrolysis as the source of energy (although other nucleoside triphosphates can replace ATP in some cases). DNA helicases unwind duplex DNA and are involved in replication, repair, recombination, transcription, pre-rRNA processing, and translation initiation. Mechanistically, DNA helicases are divided into those that can translocate in the 3'-5' direction and those that translocate in the 5'-3' direction with respect to the strand on which they initially bind. This entry describes a number of DNA helicases that translocate in the 3'-5' direction. Many of the enzymes require a 3' single-stranded DNA tail. The Rep protein is a component of the bacterial replisome, providing a replication fork-specific motor. The UvrD enzyme, found in Gram-negative bacteria, is involved in maintenance of chromosomal integrity. The RecQ proteins are a family of eukaryotic helicases that are involved in DNA replication, transcription and repair. The Mer3 helicase, found in fungi and plants, is required for crossover formation during meiosis. cf. EC 5.6.2.3, DNA 5'-3' helicase.",384,1.0,-0.043995414,-0.082096465,-0.05071128,-0.043905467,-0.020708976,0.046687067,-0.01392149,0.016213981,0.0049619735,0.022756783,0.025366666,0.060787633,-0.021214608,0.03537815,-0.01780247,0.041477107,-0.098643705,0.07283467,-0.0451773,-0.06035386,0.10487831,0.044842333,-0.048209894,-0.020755896,0.010657556,0.073722914,0.0046665985,-0.0064004804,-0.00010061418,-0.11431138,-0.017272493,-0.08246686,-0.079899676,-0.044818293,0.10500074,0.0839383,-0.0027217655,-0.0063023656,0.01014866,0.009364638,0.08299744,0.031338256,0.0007213628,0.04339679,-0.062874824,0.03470913,0.033072673,0.07849111,0.05210924,-0.022726553,-0.008571697,-0.04474351,0.004654131,-0.0016223016,-0.019046504,0.06729925,0.0010305729,0.004962566,0.02348519,-0.08133491,0.06708526,-0.061651133,0.028248861,-0.015277593,0.11954256,-0.04650881,0.078674495,-0.03028544,-0.0013734332,0.025087317,-0.037035983,-0.034197357,-0.021161662,0.0957894,0.020655418,0.0356992,0.01799207,0.00953174,0.0059005735,0.05871171,-0.05590432,-0.025693063,0.06269089,0.06560693,0.043606885,0.004934271,0.039516065,0.040084034,0.057305533,0.035227656,-0.0833454,-0.047110036,0.015943367,-0.108657844,0.02364798,0.024454435,-0.0013361531,0.03509827,0.045403365,-0.088923275,0.09066843,0.022079382,0.024524711,-0.0002128642,-0.018019613,0.079416305,-0.0650891,0.10903765,0.036085848,0.032013588,-0.022828525,0.025734706,0.047857203,-0.0579378,0.0011808884,0.08159756,-0.063013636,0.018202174,-0.0014103254,0.015212658,0.008860083,-0.036796723,0.059299238,0.033826064,-0.04081158,-0.04601245,-0.07506032,1.3104705e-33,-0.029262234,0.02394859,0.013946751,0.022568317,-0.030824292,-0.014775294,-0.0856418,0.016913654,-0.07168027,-0.037852664,-0.00881808,0.04420472,0.07813832,0.00079537,-0.07774026,-0.07484968,0.026035406,0.02145639,-0.0870674,-0.013044097,-0.016959034,0.054443035,0.022848155,-0.00080831925,0.036772467,-0.030163445,-0.031518366,-0.013435196,0.0075745024,-0.021239156,-0.025572315,-0.041398194,-0.07434029,0.064221434,0.04410201,-0.01653421,-0.023073874,-0.055486288,0.026696604,0.065060325,-0.03783941,-0.029741125,-0.033736613,-0.06041864,0.05829009,-0.10182718,0.031517196,-0.0008888146,-0.08605261,-0.058859073,0.07888429,0.007620226,0.05191211,-0.11019958,-0.03095952,-0.046605367,0.028907144,0.045208342,-0.013968185,0.037334245,0.018829368,-0.010880791,-0.057278086,0.02588076,0.030150592,0.045865964,-0.036639884,0.012833455,0.07328609,0.113730475,-0.04844903,0.01518887,0.08216657,-0.0019614485,0.008718388,0.02155583,-0.096372105,-0.015621423,0.016285686,0.082417615,-0.04310614,-0.04660256,-0.06418129,-0.08403947,-0.1005847,-0.009125659,0.010825375,-0.10447049,-0.037897345,0.019210046,0.11863918,-0.040442444,-0.01569912,0.0027420935,0.025945902,-3.451642e-33,0.04977002,-0.06496817,0.026718587,-0.00916839,-0.06462485,-0.001375644,0.0365053,0.05326715,-0.039140955,-0.15536767,0.014838923,-0.07764652,-0.03494708,-0.024267895,-0.007214531,0.049394883,0.01012952,0.046825882,0.03246837,-0.018642724,0.046870213,0.13098735,0.020918446,0.082928106,-0.023178522,-0.014583018,-0.046377186,0.014380403,0.11888749,0.046772074,0.0058965837,0.0040588947,0.022494921,0.00532899,-0.032728985,0.044556655,-0.03032705,0.029851034,0.08564024,-0.015669702,0.045050766,0.033259585,0.0156064965,0.013992387,0.019114198,0.09054693,-0.07024575,0.111078165,-0.036337044,-0.0360035,0.029676758,-0.00725549,-0.014308485,0.037144303,0.030369231,0.028459657,-0.01275053,0.0043012295,0.029438747,0.057349797,-0.07615262,-0.06467518,0.031430893,-0.009616052,0.004580741,0.034629688,-0.076762326,-0.020323137,-0.009140294,0.000789935,-0.019924372,0.007417601,0.032584567,-0.028954552,0.045373123,-0.0023664543,-0.043163437,-0.044714727,-0.034306344,-0.041478246,-0.12738283,0.038306616,-0.05315875,-0.0498728,0.06432408,-0.046904378,-0.01613599,0.07907393,0.022448048,0.005279757,0.014577812,-0.026799949,-0.007562758,0.07749529,0.04238722,-4.5668127e-08,0.05937989,-0.014860564,0.08912701,-0.033933755,0.027637534,0.08667602,0.032731313,0.02957264,0.09657487,-0.012215412,0.0052691656,0.0120880725,-0.011827317,-0.02814535,0.041329008,0.061480723,-0.071794435,-0.053624034,0.010136683,-0.0868552,-0.019455763,-0.07137389,-0.06757063,0.104334615,-0.07929253,0.03139336,0.045797873,0.046039756,-0.025407221,-0.050327558,-0.044758517,0.0011356266,0.03199576,-0.045941994,-0.12458722,0.009650159,0.029336473,-0.025308551,-0.0038044078,0.028076911,0.074116096,0.037592135,-0.043627262,0.010718955,-0.022064604,-0.0011936818,-0.021636533,0.031279296,-0.076719,-0.07279498,-0.022618897,-0.013502909,-0.014715424,-0.04858857,-0.083649196,0.011848784,-0.00788059,-0.03349752,-0.025820367,0.017974809,0.024475971,-0.003155246,0.14288251,-0.16052634 +6.3.2.61,"The eukaryotic tubulin proteins, which polymerize into microtubules, are highly modified by the addition of side-chains. The polyglutamylation reaction catalysed by this group of enzymes consists of two biochemically distinct steps: initiation and elongation. Initiation comprises the formation of an isopeptide bond with the gamma-carboxyl group of the glutamate acceptor site in a glutamate-rich C-terminal region of tubulin, whereas elongation consists of the addition of glutamate residues linked by regular peptide bonds to the gamma-linked residue. This entry describes enzymes that act on both alpha- and beta-tubulins.",384,1.0,0.001937389,-0.113844365,-0.020217065,-0.08507549,-0.015100688,0.064301096,0.050761383,0.058180336,-0.044468317,0.03841667,0.051719714,0.04523836,-0.016249219,0.07533931,-0.049496654,-0.0012926345,-0.061024684,0.039550528,-0.020470943,-0.06302961,0.020786673,0.011165597,-0.032535207,-0.0037358832,0.067018524,-0.0058622225,0.013614595,-0.08598566,0.03539039,-0.05195845,-0.09473438,-0.03587562,-0.04684722,-0.04823212,0.07360372,0.011828876,-0.087062575,-0.117670104,0.029425561,-0.048834447,0.10928208,-0.0020470738,-0.006780542,-0.06452213,0.016537676,0.014950239,0.033533715,-0.006592689,0.053729065,0.023221994,-0.015706202,-0.098703876,-0.0070874183,-0.035686813,-0.04282458,-0.014488567,-0.013676465,0.0191662,0.079369396,0.05436734,-0.0595527,-0.0024857009,0.033237197,-0.0105371205,0.02914319,-0.08397784,0.020403562,-0.037874162,0.008134779,0.030450998,-0.038269192,-0.06596995,-0.07651545,0.040400952,-0.044802893,-0.062089067,-0.009005092,0.074735194,-0.05472602,0.086411856,0.022775976,-0.028567627,0.114832506,0.02674508,-0.015318858,0.029629953,0.01583897,0.07037725,0.05918917,0.016958002,-0.0085412385,0.033705257,0.0065231845,-0.020868221,-0.07416607,-0.080603965,0.021237126,0.016243082,0.05021005,-0.03374206,0.0024141958,0.017878585,0.0062016384,-0.0052695554,0.0010261111,0.000757609,-0.048176665,0.025990652,0.021312902,0.0124516385,0.0055125635,-0.018688431,0.0793872,0.013062712,-0.04589673,0.030287448,0.07616601,-0.049235936,-0.0058080126,-0.029991928,0.030064322,-0.023868058,0.055917896,0.021554053,-0.13984156,0.016619792,-0.13959453,2.2364954e-33,0.059090376,-0.06473777,0.025746053,0.007824546,0.025697827,0.044348594,-0.049497455,-0.032295886,0.036925983,-0.062373377,-0.10961065,-0.00267078,0.05106313,0.06944911,-0.028312081,-0.031087015,0.0006677158,-0.026492884,0.054061826,0.0021777062,0.011467421,0.06503096,0.029986424,-0.005870964,0.052794155,-0.030688481,-0.06029793,0.007796287,-0.03729318,-0.013746559,-0.010653086,-0.0875296,-0.1253005,0.08402486,0.061578486,-0.028872121,0.033338405,-0.064538114,0.038831808,0.017561965,-0.01269179,0.0012810156,-0.080819815,-0.066062085,0.040685233,0.012304556,0.003776301,0.022575632,-0.022281371,-0.0019086262,0.06341158,0.026577113,0.041868072,0.023591625,-0.020243194,0.07761799,-0.0629289,-0.060680438,0.013941558,0.09524252,0.0021448506,0.025894586,-0.017760439,0.02763514,0.024807673,0.06138323,-0.022104764,0.018480755,0.040455047,-0.041004907,-0.06990901,-0.04680062,0.09282156,0.024371216,0.026137944,-0.07374617,-0.09619872,0.008019728,-0.065794595,0.0134776095,-0.014945228,-0.011273452,-0.006379148,0.011243314,-0.0062576453,0.017519502,0.07560083,-0.010958625,0.003197557,-0.003144292,-0.007670247,-0.01571479,-0.00638001,0.12636432,-0.00081944896,-4.952261e-33,0.09121324,-0.12974459,0.031793196,-0.03242335,-0.07053494,-0.015453183,0.05467785,-0.054022625,0.04189108,0.019151945,0.014289718,0.059366208,-0.028423669,0.01168816,0.0032137684,-0.027609933,-0.025420267,0.06896049,-0.045850765,-0.06687946,0.008119952,0.031990703,-0.010947163,0.03301417,0.007099411,-0.016861659,0.017643249,-0.019980505,0.020808637,0.07617562,-0.06886272,0.049784344,0.014808605,-0.046981193,0.0025288272,-0.013225116,-0.02272781,-0.011036619,0.04359045,-0.022708528,0.08107111,0.056097172,-0.018813292,0.006220138,0.04996522,0.067626126,-0.03190206,0.017007168,-0.124027595,-0.05498813,0.041374955,-0.01636639,0.058263402,-0.020182192,0.006531283,-0.044139635,0.10462085,-0.003407338,-0.0085184,0.02989447,-0.008086677,-0.06987538,0.016275499,-0.00034038507,0.038042445,0.054517966,0.05192542,-0.0023931668,0.0057423864,-0.0049261097,0.033902664,0.004795646,0.0665916,0.092388615,0.06346971,0.01377031,-0.05810977,-0.019571668,0.05555302,-0.087609194,-0.015230663,0.03673675,-0.002202421,-0.044815637,0.04055659,-0.08581294,-0.03751321,0.11592072,0.013691764,0.0112332245,0.03192752,-0.041641217,-0.03206886,0.1367184,0.12460324,-4.1449344e-08,0.030448738,0.030558279,-0.02751494,-0.0069338838,-0.03327454,0.044232264,0.0030958818,0.027857978,0.05082293,-0.08193012,0.016267007,0.09889274,-0.025240686,0.051781267,-0.029755417,0.09277432,0.008971542,-0.019125286,0.0010121496,0.019516995,-0.10449502,-0.008250659,-0.023731679,0.021161227,-0.059884094,-0.120421655,-0.02056085,0.13467477,-0.07519407,-0.059208695,-0.04791318,0.032635085,-0.025338316,-0.058530316,-0.07886966,0.010512576,0.020946177,-0.088608235,0.06973107,-0.0062682605,-0.019069834,-0.07192557,0.030746961,-0.07838554,-0.020726452,0.05960008,0.018231485,0.0045887027,-0.03496657,0.010251273,0.094671376,0.022657951,0.04939193,-0.06102333,-0.100200854,-0.023385797,-0.057013076,-0.032889534,-0.019343466,-0.04098556,0.000838954,-0.0008966389,0.1666384,-0.09037248 +6.3.2.62,"The eukaryotic tubulin proteins, which polymerize into microtubules, are highly modified by the addition of side-chains. The polyglutamylation reaction catalysed by this group of enzymes consists of two biochemically distinct steps: initiation and elongation. Initiation comprises the formation of an isopeptide bond with the gamma-carboxyl group of the glutamate acceptor site, whereas elongation consists of the addition of glutamate residues linked by regular peptide bonds to the gamma-linked residue. This entry describes enzymes that act on beta-tubulins and other proteins with glutamate-rich regions but not on alpha-tubulins.",384,0.99999994,-0.0044662207,-0.12020531,-0.012777775,-0.07902685,-0.014576679,0.061529964,0.049796537,0.058811057,-0.04477475,0.032279145,0.046052027,0.052299395,-0.011380916,0.07540314,-0.03598744,0.0046704332,-0.047264222,0.038231622,-0.027685696,-0.06165445,0.025403377,0.011931396,-0.035764698,-0.013704667,0.06576232,-0.010722486,0.0071938173,-0.08240625,0.040219806,-0.054495256,-0.09039072,-0.03259621,-0.059563313,-0.044050485,0.07733438,0.021757074,-0.08996491,-0.11554171,0.025615443,-0.05315219,0.109122425,-0.00070906396,-0.008628045,-0.07119578,0.012010778,0.012612726,0.033429246,-0.0088428585,0.04156421,0.015184418,-0.018186454,-0.10181926,-0.002722168,-0.040101677,-0.036480017,-0.0134548005,-0.015150115,0.014709982,0.077468805,0.043772664,-0.059856795,0.002822703,0.030559469,-0.015360612,0.03530872,-0.08193609,0.023394382,-0.040190317,0.012061345,0.031192407,-0.028497517,-0.05625811,-0.07953212,0.040378116,-0.04246933,-0.06183508,-0.017515158,0.07362565,-0.053544898,0.08452533,0.025534116,-0.029980708,0.112406634,0.02772977,-0.014379428,0.017367132,0.016533883,0.07376904,0.04773277,0.018476393,-0.000566848,0.030898225,0.012763863,-0.015704254,-0.07783447,-0.083868586,0.01989871,0.007996496,0.052199934,-0.03594741,0.00017593704,0.017161531,0.004156006,-0.013263617,0.0011244061,0.0017383805,-0.043900006,0.030077795,0.014861456,0.0148209315,0.0077445228,-0.009442308,0.08278267,0.013827463,-0.049180992,0.02234499,0.08234596,-0.05223774,-0.013784612,-0.02487911,0.027808191,-0.032217655,0.05834195,0.02648409,-0.14208381,0.0145823965,-0.13926825,2.5484839e-33,0.057567433,-0.07269535,0.023134563,0.0042408714,0.027676083,0.045542635,-0.05067036,-0.034831826,0.04507387,-0.06617119,-0.112568565,-0.0034596177,0.054646555,0.07772034,-0.025322456,-0.02954046,-0.0020690064,-0.031675145,0.059084706,0.0032484361,0.009284532,0.0656853,0.031245835,0.0020837374,0.0442885,-0.024846813,-0.06006089,0.0027975913,-0.047871616,-0.012327176,-0.020793032,-0.09567497,-0.12150816,0.087573975,0.06271619,-0.019561402,0.033326514,-0.07244963,0.03998372,0.01706976,-0.018669188,-0.0054433537,-0.08722833,-0.07688638,0.047165915,0.018193295,0.007239711,0.015419665,-0.03173676,0.0027371459,0.067282744,0.030078439,0.038350426,0.020438999,-0.019284371,0.071950085,-0.054176223,-0.056147125,0.0231603,0.09417525,0.0011759067,0.029199813,-0.016301634,0.018448254,0.026078917,0.06657093,-0.010826146,0.01007332,0.035563156,-0.036703926,-0.06590443,-0.045955874,0.0910908,0.026740175,0.027737021,-0.08094667,-0.09795752,0.009441824,-0.05609206,0.022482233,-0.0063883862,-0.0139810955,-0.0042873956,0.007839717,-0.010350688,0.011643579,0.075499624,-0.020055935,0.0041875527,-0.003025051,-0.0035477008,-0.022835752,0.0036363958,0.12689331,-0.0020223272,-5.4010608e-33,0.09001219,-0.12746821,0.03595914,-0.03071855,-0.072224006,-0.0146185495,0.05267968,-0.041184556,0.040339667,0.018155674,0.022932416,0.053615324,-0.021649273,0.014517116,-0.0022151154,-0.02703264,-0.023702776,0.06441033,-0.045982827,-0.0682998,0.0060869534,0.033559293,-0.011511728,0.03810418,0.013033736,-0.014348652,-0.0026055519,-0.023448044,0.015718123,0.0765962,-0.06560889,0.04894202,0.016879354,-0.056878097,-0.0016944846,-0.013250462,-0.027030792,-0.0076092016,0.038971014,-0.028549653,0.08239781,0.059712768,-0.009790943,0.0051809335,0.04513174,0.0648553,-0.033987552,0.0068565104,-0.11951909,-0.05374928,0.042928,-0.0024029405,0.05728809,-0.026584504,0.0060200905,-0.04475539,0.107363574,-0.00701275,-0.016429262,0.029000815,-0.018155051,-0.07508498,0.02010252,-0.009032553,0.042398322,0.06463806,0.051549677,-0.0016994921,0.013368268,-0.0053042728,0.03916215,-0.004654445,0.065290526,0.09293745,0.058986016,0.015411869,-0.05809828,-0.015506136,0.052166052,-0.088932075,-0.008010036,0.03176827,-0.0056288843,-0.04794771,0.041252423,-0.089075744,-0.043139447,0.112343244,0.015673375,0.009358096,0.024583606,-0.042044453,-0.02482968,0.14362384,0.12506951,-4.223517e-08,0.02772675,0.028717315,-0.024170626,-0.0049855337,-0.034671992,0.04183903,0.003023467,0.029968953,0.05107736,-0.07580743,0.020272117,0.09600838,-0.034423668,0.05209592,-0.031580165,0.09288148,0.0060561136,-0.020996554,0.0013062953,0.012280414,-0.108732246,-0.006476518,-0.029752154,0.022427998,-0.056526534,-0.11802169,-0.015473008,0.1273593,-0.063680105,-0.064591736,-0.049773112,0.038479734,-0.02044213,-0.045472343,-0.07636209,0.00791171,0.027848674,-0.08330376,0.06574676,-0.004155976,-0.02197889,-0.062436305,0.02756268,-0.07712303,-0.02129034,0.05517666,0.018009128,-0.0014818781,-0.03821469,0.010297297,0.099861644,0.021538986,0.048168544,-0.06084118,-0.10271398,-0.016188407,-0.061471228,-0.031312317,-0.015302548,-0.040224444,-0.0011495384,-0.0005766156,0.17299135,-0.08374902 +6.7.1.1,"The enzyme, characterized from Streptomyces cremeus, catalyses the last step in the biosynthesis of the ortho-diazoquinone cremeomycin.",384,1.0,-0.05752255,0.026798932,-0.10076845,-0.0048595387,-0.02085602,0.045166474,-0.056767613,0.05480327,0.060886107,-0.053309914,-0.019054094,-0.01594439,0.08122434,0.048331484,-0.09386868,0.06358598,-0.08825863,0.014520438,0.008453636,-0.034554932,0.1032263,0.07149078,0.012989202,0.05384555,0.089368254,0.024066783,-0.014322173,0.02146443,-0.029757801,-0.0018887098,0.021350225,-0.043992154,0.025503429,-0.07848031,0.10969515,0.04566075,-0.015631255,-0.048579067,0.12728645,0.063312165,-0.054515317,0.022888364,-0.07455033,0.055670876,0.016605193,-0.005959478,0.044385675,0.0619543,0.03108799,-0.020357287,-0.023610028,-0.042366292,-0.09827124,0.1186068,0.016387107,0.08411275,-0.035391264,-0.021345908,-0.045484185,-0.0041382364,0.028191557,-0.045703333,0.00807036,0.039428756,-0.052519836,-0.008109896,-0.025575269,-0.08595389,0.028922992,0.005748607,-0.059471674,-0.060892444,-0.029749965,0.008901888,0.030603899,0.009464808,-0.0006620037,0.035104476,-0.08179,-0.051547978,0.058097284,-0.06654041,0.009345321,0.098407336,0.046792712,0.03424853,0.06541914,-0.008148889,0.105684556,0.058562774,-0.004655382,-0.008016016,-0.004539063,-0.09918405,-0.00658417,-0.006612021,-0.049247663,0.01913765,0.07062981,-0.012625272,0.0015928389,0.011956819,-0.011665994,-0.058415912,-0.0010360775,0.045474682,-0.03440572,0.057518534,0.021388859,-0.052123584,0.018226705,-0.0068782456,0.030546693,-0.0026817634,-0.0012361481,0.09047407,0.07727213,-0.0029198339,-0.04146315,0.020249635,0.019458512,0.011822225,-0.04830042,0.028954312,-0.039234847,0.06668081,-0.07205871,1.9435254e-33,0.0032391963,0.10893807,0.0044271164,-0.05101166,0.011829285,0.04285701,-0.13101062,0.044408616,-0.036543895,-0.074956626,-0.07241712,-0.05743914,-0.013226931,-0.006143475,0.01595875,-0.044446576,-0.00821073,0.052800488,0.005420108,-0.017599449,-0.0023684276,0.049191073,-0.07689072,0.0026576994,0.01579687,0.10688305,-0.011377374,0.008498563,-0.008747046,-0.062024802,0.013552456,-0.056511324,-0.02683916,-0.04224443,0.037425477,-0.024320768,0.008494766,-0.05387304,0.026174203,0.054569844,-0.023553815,0.031374145,-0.021987159,0.006597711,0.0053108474,-0.04809522,-0.011965671,0.094030276,0.101927325,0.0388797,0.0055370457,-0.0102406,0.13378295,0.017426217,-0.09800166,0.003760868,-0.0119527895,0.0025592789,0.039150227,-0.0052929474,0.014643798,0.0032943462,0.030707072,0.034088496,0.008670202,-0.038875677,-0.04924803,0.044727933,0.03303056,0.09031595,-0.090229616,0.038660992,-0.005753894,-0.016647965,0.070427865,-0.028223047,-0.056267664,-0.03161062,0.046869002,-0.0021375536,-0.06992163,-0.036840532,0.0009066265,-0.06437176,-0.0039472575,0.037621178,-0.02618778,-0.06333381,-0.0038314855,0.10906293,-0.06361695,-0.06861169,-0.04470834,0.051833093,0.016417366,-2.6003147e-33,0.07843201,-0.11252634,0.06323063,-0.0038505052,-0.06885282,0.051730316,-0.110271774,-0.0009781171,0.008073934,-0.04669967,0.027715683,-0.02772522,0.027589748,-0.032843307,0.00914274,6.1775965e-05,0.022753656,0.103841774,0.027578086,0.022770617,0.014215722,0.071435496,-0.045302264,-0.0071388986,0.034797553,0.01993646,0.021942869,0.017570067,0.044875298,0.08076283,0.009486592,-0.115940444,-0.005755098,-0.012410066,-0.048878167,0.15298055,-0.026959915,0.036457345,0.09016673,0.033449948,0.06417152,-0.006859333,0.0013711653,0.058121607,-0.009999627,0.03699517,-0.090826035,0.097612806,-0.0074313204,-0.04751508,0.04911978,0.03026468,-0.022839943,-0.02452135,0.00550283,0.015584005,-0.018848754,-0.06635419,-0.0404589,-0.021820068,-0.01859865,-0.0451256,-0.0064385096,-0.0024502797,0.028673416,0.0669443,-0.041704785,0.065643206,0.030221999,-0.030785942,-0.012307479,-0.044300493,-0.033758707,0.08467663,-0.009741376,0.0063166437,-0.07756622,-0.11613994,0.0064360714,0.0027474004,-0.052283723,-0.040186338,0.007929892,-0.044148073,-0.052128892,-0.018699428,0.0027517453,0.042491287,0.0138615,0.030521916,-0.0021889182,0.05500168,0.027005259,0.018634945,0.023830753,-2.7196599e-08,0.07434786,-0.06338166,0.10902818,-0.006099233,0.028651014,-0.028920628,0.011372686,-0.05156888,0.016874097,-0.046276677,-0.041024346,-0.011245058,-0.008462627,-0.013283542,0.009642465,0.03823104,-0.05219044,0.00068555196,0.009686772,0.018089335,-0.113706715,-0.012861686,-0.08062978,-0.01213398,0.03400396,-0.08614537,0.021846773,0.067480505,-0.024451481,0.026311489,0.03926035,-0.020007322,-0.054566085,-0.032661762,-0.090156026,-0.002145554,-0.06738123,-0.06536107,0.04620494,-0.04562569,0.04691855,-0.03716939,-0.025801294,0.01624948,-0.0993155,0.011105853,0.006455264,-0.04640561,-0.033937488,0.0048586964,0.06320131,-0.040293336,0.043602165,-0.03935583,-0.0670889,0.008551355,0.053272747,-0.04355262,-0.009521539,-0.052704886,-0.054819807,0.015680136,0.23928048,-0.071307756 +1.1.1.427,"The enzyme from the archaeon Saccharolobus solfataricus is tetrameric and contains zinc. L-fucose also is a substrate. In contrast to EC 1.1.1.116 (D-arabinose 1-dehydrogenase (NAD+)) and EC 1.1.1.117 (D-arabinose 1-dehydrogenase [NAD(P)+]), this enzyme is specific for NADP+.",384,1.0,-0.04665678,0.024557922,-0.0515114,-0.045842033,0.07181033,0.031310774,-0.08220474,0.0488842,0.037068978,0.002850672,-0.0035407695,-0.07378174,-0.09474181,-0.003590485,-0.06512627,-0.057072975,-0.006646028,-0.0016538497,0.023814393,0.004479929,0.082400955,0.009165829,0.0079542305,-0.04465336,0.058890823,0.0016564189,-0.023326995,0.034735326,-0.01660826,-0.035266157,-0.015766349,-0.008814147,0.055400386,-0.036345087,0.0144177945,0.05720451,-0.051547524,-0.029372463,0.012130009,0.033980902,0.03092916,0.017299907,-0.008371908,-0.06465277,-0.038717423,-0.053670324,0.008868684,0.047371127,-0.009690681,0.01065956,-0.032914877,-0.09309223,-0.03637567,0.041198265,0.016221136,-0.016030727,0.0051000733,0.016228363,-0.054729458,-0.06459115,0.024461875,0.008354345,-0.015837157,-0.0028474545,0.008928525,-0.04632594,0.040590502,-0.07959642,-0.0049868617,-0.02746989,-0.117449805,-0.00926409,0.027773196,0.060535017,-0.047369137,0.10052398,0.0024977291,-0.09719833,0.041259397,-0.029097317,0.07691187,0.03829928,-0.07032192,0.05059619,0.04440014,0.01230822,0.018549027,0.023583647,0.0018891314,-0.016577376,0.08647376,-0.013235484,-0.061915025,0.016421517,-0.103851244,0.050400693,-0.00013305905,0.09645555,-0.033907086,-0.059441134,0.032418527,0.095371366,0.031569995,-0.10388074,-0.04871785,0.027263984,-0.0032455204,0.114087924,-0.003913462,-0.027007908,-0.008019543,-0.044061136,0.018924791,-0.014169854,-0.042669795,0.07483588,0.009682771,-0.076340415,-0.060837723,-0.008119758,0.031100398,-0.01900097,0.13080317,0.046249293,0.032272406,0.07713297,-0.11825695,7.296649e-34,0.07837383,-0.0042731664,-0.03323558,-0.045185577,0.029058978,-0.018248856,-0.04389868,0.06574112,-0.07719935,-0.018709095,-0.12271594,-0.022789719,0.02997638,0.013529532,-0.022176344,0.06553636,0.0003365511,-0.053005517,-0.0085941935,0.022029292,0.0054919906,0.06736891,-0.024489053,-0.03471535,0.08318792,-0.024025531,-0.038032316,0.02261753,-0.00893388,0.0037380047,0.0440546,-0.1184155,-0.14482369,0.032925293,0.12346247,0.03599166,-0.024534324,-0.031385552,-0.048370894,-0.03539077,-0.027779747,0.027910748,0.045212347,-0.0011083848,0.07704205,-0.050119836,-0.030193917,0.07750992,0.08006382,0.007864094,0.057758573,0.008555554,0.06374685,-0.067332156,-0.06501895,0.08916875,-0.0047784126,0.08786681,-0.030470941,0.10294026,-0.0057194876,0.08321956,-0.035909526,0.07014732,-0.049699023,0.037861634,-0.11403042,-0.042616237,0.03172107,0.04732565,-0.0146222245,-0.02880364,0.0853291,0.0515148,0.02171925,-0.01999229,0.037515916,-0.0043505095,0.004531423,-0.0017724871,-0.039846774,-0.061511092,-0.057750843,-0.01632924,-0.09369872,0.053682037,0.011881138,0.0035250515,0.023029998,0.008015974,0.027089301,-0.018018749,-0.04521898,-0.04929354,0.013049416,-2.8026785e-33,0.00019849047,-0.01891508,0.034704637,-0.12340001,-0.031881914,0.07587313,0.04055196,-0.052621648,-0.0034030026,-0.07517217,0.08350912,0.0069422666,0.031077106,-0.04831643,0.015737431,0.004460775,-0.07467705,0.04891078,0.029026087,-0.027749078,0.0029037425,0.1386355,0.050433334,-0.013080029,0.041415658,-0.052796174,0.023791434,0.07455598,0.0047949194,0.022215243,0.017813409,0.05906261,-0.021673286,-0.03010455,-0.106931075,0.014356502,-0.04781879,-0.08740555,0.052921776,0.08300384,0.002801332,0.032728836,0.0069428463,0.043195307,0.090234704,0.012934209,-0.11274115,-0.037580274,0.020267695,-0.033879824,0.03828798,0.01205696,0.014596803,-0.0074923113,0.08495863,0.06974869,-0.037384164,0.07107335,-0.009756184,-0.018004641,-0.014583692,-0.025779862,0.048478916,-0.027294999,0.08294594,0.024752077,-0.009479282,-0.010563549,0.0056820693,-0.0079500545,0.11757237,0.02608881,-0.05705398,0.040990576,-0.00028281743,-0.06026544,-0.09093735,0.037967186,-0.05209891,-0.028430985,0.024516081,0.024962153,-0.0003254028,-0.011256083,-0.0012879028,-0.030470533,0.003750979,0.06811029,-0.051484767,0.02792648,-0.034303874,-0.012391963,-0.06727873,0.056005258,0.0043717558,-3.81948e-08,0.042184353,-0.009800358,-0.025072955,-0.071138315,-0.004643215,0.03238533,0.029619796,-0.058507733,0.0046768906,0.039108347,-0.027962025,0.13695943,-0.011989511,0.055611044,0.024768021,-0.02169332,-0.035535395,-0.006206921,-0.039635077,0.04122827,0.008969475,0.009458918,-0.11843655,0.05942957,0.024453271,-0.027373575,0.0036625252,-0.019656193,0.01995382,-0.0113008665,-0.019219698,0.01433913,0.05653269,-0.03682971,-0.047576025,0.06415686,-0.103588775,-0.02761444,-0.09819568,0.078784995,0.026224324,-0.083004646,0.0039105974,-0.0048923106,-0.010033303,-0.04267828,0.046959747,0.048226006,-0.030244723,0.040361457,0.03538853,-0.054790728,-0.01652541,-0.07869013,-0.049523093,-0.040644825,-0.024430644,-0.050493985,-0.0040449435,-0.007046647,0.06539432,0.00016819047,0.17817737,-0.022473408 +1.1.1.428,"The substrate of this enzyme is formed as an intermediate during L-methionine salvage from S-methyl-5'-thioadenosine, which is formed during the biosynthesis of polyamines. The human enzyme also functions as a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes, thus providing a link between gene repression and the methionine salvage pathway. A similar, but NADP-specific, enzyme is involved in dimethylsulfoniopropanoate biosynthesis in algae and phytoplankton.",384,1.0,-0.07118494,0.03628996,-0.06473592,-0.040050942,0.061904904,0.07364862,-0.046963435,0.043190468,0.029599234,0.01716348,-0.04895708,-0.020412348,-0.03060896,0.01827752,-0.07578166,0.088286586,-0.10264975,-0.007361993,-0.0014697523,0.016785221,0.07769774,0.09692168,-0.06970758,-0.032103475,0.096175954,-0.025941221,0.03862731,0.052598704,-0.022485761,0.034787614,-0.052904688,0.008761101,0.0072063287,-0.06855173,0.03882565,0.15138885,-0.037130635,-0.03163155,0.02502709,0.020529706,0.0684997,0.016250141,-0.061537534,0.02484076,-0.02682439,-0.06015791,-0.036395818,0.046523903,0.002903199,-0.050703026,-0.0971084,-0.0008955525,-0.0010668274,0.02743587,0.037984822,-0.0044752285,0.02971208,0.02966943,-0.05007188,-0.09950217,0.0027908913,-0.08038682,-0.017997684,-0.030883042,0.0635571,-0.056421984,0.014820503,-0.060964525,0.032373022,-0.031687777,-0.09926594,0.0009999598,0.009415427,0.028346622,-0.051834714,-0.02480805,0.0019001589,-0.019923232,0.04647588,-0.021538144,0.038734183,0.039586406,0.046678778,0.023609122,0.034928743,0.029633349,-0.008574475,0.0480717,0.043566287,0.005670613,-0.033883866,-0.04306237,-0.010841954,-0.07193469,-0.12805049,0.022933895,0.03526699,0.009103289,-0.02004496,-0.004354425,0.030749986,-0.006553616,-0.08310832,-0.099259585,-0.06593318,0.0023038734,0.024337322,0.09756563,-0.062526815,0.0136815095,0.020397278,0.01253275,0.023220861,0.06063411,-0.027740436,0.15433426,-0.002487961,-0.089719236,-0.06500515,-0.05274284,-0.019504523,-0.047422327,0.103615485,0.041380793,0.03532579,0.023287835,-0.05903463,7.459012e-34,0.13421057,0.024807462,-0.028390959,-0.05335133,0.07310679,-0.03515194,-0.059418786,-0.0013718103,-0.006542542,-0.04507726,-0.09455869,-0.097503416,-0.0010317831,-0.0062004765,-0.06410306,0.0031408952,-0.028017748,-0.0014642841,0.033452556,0.00922496,-0.052803237,0.017200079,-0.030013202,0.0051702578,-0.048229974,0.029519167,-0.0248191,0.057497673,0.018604705,0.004875749,0.002959346,-0.050897077,-0.056984693,0.013996137,0.080074094,0.080211274,-0.124057785,-0.030018643,0.011774785,0.06836392,0.027175244,0.031088825,0.024536232,-0.03727243,0.045651827,-0.03060436,-0.06692274,0.051013768,-0.0019093971,0.044351526,0.025759755,-0.029485444,0.11450141,-0.03117057,-0.12584028,0.003160728,-0.043954648,-0.12402522,-0.025313802,0.08411166,-0.011763848,-0.06333764,-0.005257055,0.08918311,-0.010648183,-0.008924823,-0.030938586,-0.06079042,0.047975756,0.05899213,0.016195202,-0.060529064,0.0774684,0.06444176,-0.0019954015,-0.004218052,0.004490817,0.039495066,-0.0058917934,0.05265079,0.061318018,-0.049549915,-0.065463476,-0.04637507,-0.034635063,0.0521522,0.042431075,-0.08516934,0.05979706,0.046622686,0.00084814563,-0.10466546,-0.022643525,-0.025732607,0.013434319,-2.612901e-33,0.06106568,-0.034534812,0.066538095,-0.10123081,-0.03451221,0.06126689,0.014137869,-0.056225467,-0.023166329,-0.06814254,0.07837625,-0.003585378,0.016688375,0.005647875,-0.0061169025,0.023820372,0.045764353,0.084157966,-0.0031305095,-0.024300532,0.035537835,0.027043616,-0.041730173,0.05772793,0.030626029,-0.050749887,-0.034467623,0.04069608,-0.00203436,0.05479058,-0.035658542,0.016041232,-0.056491435,-0.03348786,0.011300993,0.03523553,-0.05524195,0.009944131,0.030202575,0.07087794,0.035778962,0.039439175,-0.017057532,0.08367119,0.04144116,0.0132752415,-0.07827774,-0.017817494,-0.039874725,-0.06019108,0.03759415,0.008035357,0.004432415,-0.022520239,0.024325602,0.08209478,0.028596705,0.037817676,-0.013680818,-0.023166578,-0.034881778,-0.048919808,-0.025559623,0.029079562,0.079220556,0.06369417,0.0223742,0.031680387,0.003662397,0.006921251,0.008445411,0.003838815,0.06715427,0.06665462,-0.08218444,-0.09958984,-0.13646907,0.03633791,0.002025991,0.022182507,0.012773261,-0.012590932,0.015974775,-0.07774215,-0.07636887,-0.038466256,0.08464289,0.09730039,-0.009123837,0.009863154,-0.065767266,0.028742779,-0.10151103,0.046802346,0.02498055,-4.088124e-08,0.06353975,-0.06705863,-0.010860841,6.626482e-05,-0.025883568,0.039874468,0.05407198,0.0073949583,0.066367574,0.008282318,-0.04916384,0.1115147,0.038502775,-0.009217784,0.021541892,0.00921583,0.013350502,0.03352835,-0.052390207,-0.018908395,-0.058161274,0.001774307,-0.06425152,0.03774675,0.04055451,-0.032535277,-0.042586822,0.07998552,0.044226404,-0.032713324,0.042164274,0.010219816,0.0033171799,-0.052199032,-0.06232679,0.055253908,-0.024397606,-0.09174223,0.04535722,0.023671206,-0.012939962,0.024506142,-0.029165138,0.045489337,0.0096568735,-0.0013473773,0.021835927,0.02700044,-0.031617302,0.02300501,0.03291418,-0.003985308,0.046537273,-0.09772094,-0.054315425,-0.015686274,-0.0043219286,-0.009715225,-0.050687093,-0.011758612,0.022601882,0.046696834,0.17517129,-0.07160516 +1.1.1.429,"The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway. It is specific for NAD+.",384,1.0,-0.0885738,0.020180797,-0.11146899,-0.016909353,0.07639641,0.06803249,-0.057899754,0.019218048,0.06901381,0.03895363,-0.037226427,-0.030759927,-0.05340139,0.05105193,-0.08797532,0.06777997,-0.03480796,-0.01663784,0.0053222855,-0.048023146,0.059579745,0.03134205,-0.003388546,-0.005559347,0.050738335,-0.045815803,0.011052061,-0.056442797,-0.06323414,-0.02285309,-0.0063285558,0.043323915,0.016449342,-0.051771607,0.03794613,0.17962694,-0.022242185,-0.07316196,0.0363694,-0.0035515775,0.016714005,0.027726997,-0.065936014,-0.040301427,-0.00569827,-0.009040655,-0.0064255353,0.036895562,0.028532257,-0.032824557,-0.0109709,-0.0033181102,-0.025332054,-0.049194206,0.018763065,0.00260063,0.027244804,-0.020702258,-0.114701554,0.01256631,0.04951432,-0.06721256,-0.018028878,0.025806958,0.021478882,-0.122341566,0.119787335,-0.032270655,0.021132067,-0.04432535,-0.15852888,-0.06275858,-0.038808595,0.019250024,0.026354015,0.018104538,-0.035110038,-0.021869116,0.042401448,-0.07530655,0.063047044,0.0150490785,-0.0053375787,0.038201414,0.09336255,0.018566525,-0.01327912,-0.007616731,0.06998455,0.03579585,0.010021188,0.055710822,0.028251575,-0.0024636753,-0.10714265,0.0019047026,0.08280118,0.012691956,0.03414623,-0.017496375,0.05197262,0.04141632,-0.055629965,-0.08174548,-0.061716445,0.000251174,0.008470766,0.08815715,0.04354034,0.0010971972,-0.05449057,0.030645337,0.0831177,-0.008817757,-0.01169251,0.084010795,0.01970822,-0.02557665,-0.07908904,0.028687106,-0.064000525,-0.0111006135,0.0011325508,0.06490191,-0.014554395,-0.029160868,-0.08240734,-2.258736e-34,0.10988373,0.0555582,-0.007453934,0.029162193,-0.030445743,0.0069060754,-0.025527831,0.028855175,-0.011577104,-0.049008,-0.007077376,-0.10554867,-0.00956115,-0.041594658,-0.02361735,-0.0041818605,-0.029595515,-0.024491353,-0.006506369,-0.014656112,-0.058595456,0.06052485,-0.043092098,-0.005307047,0.09202757,0.03641582,0.014662994,0.0094190445,-0.04451835,-0.020621613,0.051770274,-0.1039998,-0.12799516,-0.028851876,0.047258317,0.004756063,-0.0027758891,0.044678424,-0.049330298,0.046547357,-0.03031799,0.05928869,0.015552466,-0.048312258,-0.005863279,-0.01476363,-0.022381064,0.09516179,0.045675915,0.03753172,0.023757773,-0.055945236,0.1351913,-0.074059024,-0.07433262,0.0846907,0.03580321,0.0101797385,0.03786869,0.047039032,0.052277833,0.022278832,-0.071638435,0.07742782,-0.025718478,-0.010377176,-0.086524904,-0.017751776,0.048058104,0.10395833,-0.07203306,0.015824568,0.036146425,0.04246276,0.034975145,-0.05022434,-0.120217055,-0.014974351,0.016735837,-0.010206836,0.0245421,-0.0612477,-0.015099188,-0.041906055,-0.08839298,0.007292923,0.049669065,-0.016228313,0.007814819,0.017194271,0.094510816,-0.07734677,-0.009501942,-0.03429292,0.06828649,-1.3260441e-33,0.11407356,-0.028381236,-0.0034319612,-0.08790295,0.0070530986,0.056769136,0.0046615317,-0.0010712149,-0.025368996,-0.019278038,0.08536728,0.0046542683,0.019229172,-0.038837004,0.044296224,-0.013536186,0.014807723,0.024530414,-0.027374242,-0.033443477,-0.07040021,0.03694586,0.014937272,-0.08204787,-0.02285293,0.0137606375,-0.0386354,0.09576504,0.07402854,0.011300982,0.003967365,-0.03782949,-0.0665688,-0.030516641,-0.022587273,0.002422381,-0.05424427,0.01189311,-0.024415592,0.023514982,0.07364814,-0.004885982,-0.032667477,0.05591831,0.029834699,0.0491587,-0.11452257,-0.01984117,0.04113324,-0.071661234,0.08448514,0.0057352623,0.0017067918,-0.0033125742,0.06909001,0.042172108,-0.01595544,-0.030300682,-0.01598242,-0.011311309,-0.056502018,0.027253058,0.03389243,0.02848533,0.015564356,0.057766113,-0.031397767,0.06920494,0.029580528,-0.030363984,0.11811092,0.066689156,-0.0067422,0.046503812,-0.056300007,-0.091584444,-0.089641534,-0.0057994146,-0.001883262,-0.018386371,-0.011711232,-0.017968917,-0.04136004,-0.05465755,0.021515287,-0.06588841,0.02599991,0.027824815,-0.021587439,-0.0056779953,0.03255238,-0.021987194,-0.07197284,0.06304904,-0.011800072,-2.766696e-08,0.02521261,-0.059039667,0.032956816,-0.052152134,-0.018424561,0.01855501,0.09107162,0.047338817,0.061866913,-0.017398916,-0.009437892,0.07911501,0.043864913,0.039885636,0.060406636,0.033412777,-0.0735934,0.003843672,-0.023983559,-0.039125204,-0.046562377,-0.01023262,-0.12387613,0.04640485,0.047281154,-0.001098622,0.035424244,0.04423906,0.064277835,-0.056850225,-0.03602048,0.037346933,0.036097687,0.009907296,-0.07904895,0.019088333,-0.021324575,-0.028046863,-0.024319788,0.0675477,-0.007751703,-0.0038422423,-0.102168575,0.01785417,0.08548468,0.02864078,0.014698618,-0.00057089934,-0.004554174,-0.00019261077,0.008433527,-0.0020157981,-0.023686644,-0.0022189238,-0.10527882,0.0057983967,0.013906561,-0.024907121,-0.0113237,-0.081928276,0.06420525,-0.031210132,0.17380211,-0.037824415 +1.3.3.17,"The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminobenzyl)malonyl-CoA. ",384,0.99999994,-0.043261353,-0.069153346,-0.04729356,0.005913782,0.048943233,0.0860398,-0.036427885,-0.0007359424,0.08440446,-0.05844263,-0.023746459,-0.026909102,-0.08898785,0.024178449,-0.07691199,0.075483955,-0.02625758,0.010799436,0.005490537,-0.053257406,0.047718514,0.053807326,-0.012803961,-0.036624134,0.03730453,0.020498397,0.03990549,-0.02613936,-0.044860918,-0.09289979,0.05720023,-0.02334815,0.03832985,0.008908882,0.052933488,0.080493644,-0.014956725,-0.07644211,0.07667146,-0.042667214,0.020778274,-0.0046252166,-0.09554214,-0.040117867,-0.056753293,-0.02896559,-0.033111572,-0.00821105,0.06323636,-0.060293768,-0.03682129,-0.013137376,-0.05834745,0.0077054086,0.0004968103,-0.015052929,0.042017672,-0.007651721,-0.12370744,0.02265913,0.046797056,0.044757303,0.002542444,0.023894228,0.009029302,-0.074903145,0.06466353,-0.05973654,0.008510768,0.014805642,-0.107483834,-0.11940645,-0.04774037,0.04165248,0.019448644,-0.015518982,-0.08390203,-0.0582415,0.004159546,-0.081033975,0.0110623315,0.022188496,-0.0064370492,0.072550625,-0.00513126,-0.022645213,0.042326942,-0.086101174,0.09466304,0.012257857,0.034672245,0.0071006715,0.016855258,-0.07669378,0.0051019234,0.041601237,0.050666794,-0.014703474,0.030731142,0.0051291855,-0.026547354,0.063147284,-0.078748465,-0.12001018,-0.14231756,0.008094903,-0.011704245,0.072491564,0.05301817,0.007226295,-0.02829647,-0.02819178,0.0076942593,-0.005683717,-0.042785663,0.055597294,0.018792082,-0.026990017,-0.017384624,0.017633542,-0.038872343,-0.015933365,0.07119268,0.073199354,-0.015023062,0.0772364,-0.034015656,-2.6151473e-33,0.07020472,-0.0390451,-0.038668875,0.013496,-0.019934606,-0.018563239,-0.04851151,-0.010032239,-0.01629765,-0.04443896,-0.020978019,-0.07060002,0.0047033965,-0.048689548,0.04954256,0.021320146,-0.04919501,0.01393094,0.064061776,0.037379082,-0.015291474,0.052602235,-0.011078164,0.040821705,-0.023145681,0.05830935,0.0147040365,0.08493269,-0.021638777,0.002583341,0.016129883,-0.0126922745,-0.1206924,-0.01650731,0.03851204,-0.02003219,-0.008257267,0.015418429,0.020602532,0.06176654,0.08548345,0.054515623,0.05546947,-0.0022949192,-0.0085568335,-0.019937497,-0.01922449,0.1616684,0.019668937,0.02045013,-0.028908057,-0.08706393,0.11872339,-0.0024898513,-0.036918666,0.09765642,-0.015646964,-0.011967365,0.028408155,-0.007909601,-0.017190523,0.032180123,-0.0075256634,0.041000783,0.0114929285,0.009026565,-0.04210704,-0.037035886,0.030491699,0.11209676,-0.055403493,0.012620681,0.0148112755,0.06420153,0.024806065,-0.07785151,-0.057034757,-0.019428845,0.052508727,0.021833831,-0.021216763,-0.029177843,0.05830431,-0.030158773,0.0016760252,-0.036157805,-0.023474924,-0.0032848222,-0.04024083,0.08536963,0.0841345,-0.07195367,-0.050528493,0.044953287,-0.019336043,-1.3471916e-33,0.082598805,-0.11188079,0.034581177,-0.07765419,-0.09884463,0.044215966,-0.0049009747,0.06794338,-0.0512872,0.06190292,0.07978227,0.037745383,0.068338,-0.0030852372,0.014567991,-0.02836744,-0.0015013689,-0.025127059,-0.013228752,0.01376123,-0.038560398,0.04455059,-0.0052394103,-0.03827317,0.01207731,0.019793648,-0.070075594,0.06377051,-0.0137516,0.010798351,0.07120172,-0.0061070477,-0.0006662042,0.010518658,-0.025244186,0.035302058,-0.018126082,-0.025208453,-0.045701127,-0.0059812223,-0.018566988,0.07909568,-0.0044653495,-0.0076239123,0.08506683,-0.0012834572,-0.11254155,0.035041977,-0.012903732,-0.09335599,0.026195047,-0.013662495,0.02120359,0.008910985,-0.04501279,0.04919819,-0.024020381,-0.027738705,-0.02858984,0.02015502,-0.07029838,-0.058841232,0.06806159,0.040908173,0.043101,0.064484924,-0.014826437,0.08424861,0.06212408,-0.022615623,0.073835604,-0.010929716,0.026446927,0.059152864,-0.03134493,-0.062352665,-0.08437731,0.04413374,0.0011026114,-0.020414663,-0.0055781025,0.010689677,-0.084865436,-0.13308533,-0.07003655,-0.083183624,-0.0043739695,0.13936913,0.0031102786,0.025710788,-0.021276498,-0.031119702,-0.0921096,0.027592892,0.05802228,-3.4939234e-08,0.0053364434,-0.023382353,0.101687685,-0.016488288,0.059980575,-0.015240895,-0.0005942221,0.014881746,0.112042606,-0.06107365,-0.06392835,0.08501528,-0.008534989,0.03825402,0.0148657095,0.0214574,-0.03667919,0.06110998,-0.027543174,-0.04979023,-0.056194812,-0.005348451,-0.1004394,0.027924316,0.04469973,-0.06773709,0.045181703,0.034080096,-0.034045503,-0.033625595,0.004979511,0.052999478,0.041050393,0.0007207195,-0.09395999,0.0050241183,-0.03615239,-0.0567831,-0.008937257,0.08954997,0.009707578,0.025517754,-0.11267043,-0.031671304,0.06990042,0.032083355,0.03610522,-0.004926725,-0.048923105,-0.028447755,0.011824917,0.031538557,-0.060378805,-0.009019302,-0.09918038,-0.043297775,-0.016483188,-0.042307887,-0.011358232,-0.0701856,0.021248944,-0.0041334187,0.15762217,0.01051893 +1.3.99.41,"The enzyme, found in marine bacteria, participates in a 3-(methylsulfanyl)propanoate degradation pathway. Based on similar enzymes, the in vivo electron acceptor is likely electron-transfer flavoprotein (ETF).",384,0.99999994,-0.08563542,-0.016154872,-0.07753251,-0.02079974,0.1258838,0.002121471,-0.039282486,0.021893399,0.0009502081,0.01796097,0.050674077,-0.07030055,-0.053279515,0.016651724,-0.04307557,0.08756848,-0.07052385,-0.0076823845,0.0034660336,0.026445229,-0.054185808,0.051569175,-0.02143725,-0.043517143,0.018120281,0.024698602,0.03706166,-0.039033405,-0.05695189,-0.010344595,0.03690124,0.042436298,0.02286783,-0.03788965,0.014876315,0.094872326,-0.08581265,-0.15473525,-0.007164933,0.03674286,0.056531418,-0.02302364,0.025238503,-0.058653947,0.012746076,0.020982873,0.055929467,0.028922057,0.040218357,-0.008529176,-0.012695718,-0.032869007,-0.042708483,0.05156211,-0.018998874,-0.03112148,-0.005034375,-0.05088831,-0.040698837,0.01343797,0.040604047,-0.0063225674,-0.019389177,0.01475237,-0.0001616038,-0.10317592,0.014488376,-0.06344261,0.02671522,-0.0628,-0.069882095,-0.04935213,-0.013728396,0.038710106,0.012868563,0.042393338,0.0510348,-0.038325265,0.07704975,-0.067641035,0.0037229932,-0.10075257,0.008177644,0.045964584,0.043816008,0.011056845,-0.013610196,0.0021049809,-0.054621566,0.07018125,0.02735073,-0.02328685,0.035926443,-0.035027083,-0.049192723,0.05217056,0.015716828,-0.006296459,0.026201477,0.0034674385,-0.053013485,0.07098207,-0.016762132,-0.08193305,-0.061002523,-0.026452638,0.0520983,0.16328716,-0.02003523,-0.013512017,0.0022049102,-0.009117797,0.038041644,0.0048880996,-0.0065723653,0.12961188,-0.029929467,-0.10667673,-0.03698867,-0.006334715,-0.05639682,-0.010317785,0.039957598,0.079912975,-0.024281628,0.034244988,-0.05873301,-9.078508e-35,0.044141337,0.0031641605,-0.041397262,-0.06275498,0.017786078,-0.021105723,-0.029717231,-0.04340078,-0.0143791735,-0.14715236,-0.05658303,-0.031280033,0.057269193,0.041759096,-0.03332148,-0.028962735,-0.002101403,0.018125294,0.05520602,-0.04204741,0.09285254,-0.013431729,-0.015154367,-0.028080773,0.045408104,0.006448686,-0.03562185,0.035901688,-0.02666547,-0.003384576,0.055973087,-0.07141531,-0.11404907,0.0018529993,0.07986602,0.016476465,0.0052784965,-0.08347971,-0.051480167,0.037724923,-0.055336744,0.034404118,-0.024000023,0.036230214,0.015554925,-0.0365803,-0.024744103,0.062077753,0.048504557,0.039283153,0.06622376,-0.07439984,0.12286153,-0.034876436,-0.046728794,0.056227025,0.03128486,-0.008924587,-0.022125946,-0.040396325,-0.04193797,0.09968825,-0.033708766,0.08299414,0.008239732,0.06735899,0.011998448,-0.07412543,0.022595918,0.063466735,-0.06184846,0.0064055882,0.07467535,-0.03798142,0.03904768,-0.024827985,-0.14448172,-0.018141987,0.013923154,-0.014284874,-0.001548427,-0.054427836,0.004387088,0.0151106035,-0.08073609,0.013961777,0.005152824,-0.057716466,0.05990915,0.006408709,0.16309068,-0.082789555,-0.044330295,-0.0045323703,-0.0035639154,-6.9451765e-34,0.036469277,-0.047660463,-0.0052980147,-0.0018809371,-0.031367663,0.06303031,0.0085582845,-0.0050075348,0.05185148,-0.031321906,0.07346698,0.022705475,0.05365592,-0.09275852,0.055995435,-0.011269808,-0.027713442,0.055766497,0.015611795,-0.047650687,0.058119003,-0.051845174,0.06807801,0.027803062,-0.001393321,-0.01629139,-0.03438058,-0.009665527,0.028503481,-0.03360397,-0.07080713,0.037357226,-0.02913963,-0.017697848,0.04004924,0.033532146,-0.038023554,0.064184226,0.04006032,-0.0015941398,-0.009406646,0.017128859,0.007154055,0.0695102,0.02408574,0.088911384,-0.04488875,0.05919193,0.055994183,-0.02435228,0.0007410793,0.037979178,0.027705483,0.016037896,0.059929516,0.11608525,0.054776322,0.021799944,0.0070292377,-0.025875501,-0.019916859,-0.12755008,0.08176199,0.05052409,0.056174103,0.048833888,-0.014203142,0.11892669,0.02013252,-0.021984028,0.12762408,0.027934961,0.016601088,0.021929095,-0.04340556,-0.066409916,-0.06771968,-0.01201768,-0.049850646,0.05128797,0.052232526,0.0063638263,0.0058221715,-0.05181889,0.0076010264,-0.06742921,0.015662441,0.061146952,-0.009843146,-0.0233278,-0.03713724,-0.028228177,-0.059340198,-0.015119317,0.016752854,-3.3002582e-08,-0.02031737,-0.027448328,0.035450816,-0.0110153705,0.03512985,0.010635057,0.028595753,0.064481765,0.0491742,-0.010011936,-0.023710672,0.117804945,0.0039704232,-0.051425293,0.07740091,-0.021582395,0.01668092,-0.05610023,-0.041434824,-0.0023518044,-0.029503925,-0.04498603,-0.107333854,0.011486325,0.0003675373,0.02828073,0.037700433,0.064515464,0.021695836,-0.046336755,-0.019890452,0.02312462,0.002830824,0.016481847,-0.10909698,0.034044027,0.0062449123,-0.058119476,-0.03257851,0.13793309,-0.0630635,0.018651556,-0.0798724,-0.012942172,-0.0031302203,0.07964681,0.05247137,0.013925432,-0.03422364,-0.051261403,0.06623543,-0.057336118,-0.046391632,-0.04130412,-0.099497706,0.019366898,-0.0542337,-0.010013564,0.020910976,-0.035208225,0.019041562,0.024421947,0.16632049,0.008240056 +1.5.3.24,"The enzyme, found in some bacterial species, is composed of four different subunits and two active sites connected by a large ""reaction chamber"". An imine intermediate is transferred between the sites, eliminating the production of toxic formaldehyde. The enzyme contains three cofactors: noncovalently bound FAD and NAD+, and FMN that is covalently bound to a histidine residue. In the absence of folate the enzyme catalyses the reaction of EC 1.5.3.1, sarcosine oxidase (formaldehyde-forming).",384,1.0,0.02338539,-0.053293854,-0.10698016,-0.008961991,0.14404337,0.0035321366,-0.012237979,0.04640379,0.07963665,0.017202388,0.02503441,-0.07469842,-0.019414367,0.088878825,-0.032266088,0.0015834583,-0.101340614,-0.05999525,-0.029684195,-0.021658996,0.018114513,0.036486886,-0.009567356,-0.011610999,-0.020308021,-0.018366227,0.055579145,-0.060510695,-0.055257495,-0.051649325,-0.00940922,-0.0246532,0.065601416,-0.059603486,0.061388675,0.026526121,0.0374046,-0.053432573,0.04523185,0.013284633,-0.026027871,0.031786785,0.015558274,-0.050385203,0.030807912,-0.00018327139,0.029895805,-0.02039213,0.048342064,0.014930336,-0.04419831,-0.034329876,-0.069271505,0.06764061,0.02492427,-0.006038523,-0.050693154,-0.04258453,-0.05391996,0.05687632,0.0812867,0.01297253,-0.010504789,-0.031159025,0.060152438,-0.06629379,0.038668144,-0.11269126,0.024276892,-0.030226307,-0.051855974,-0.116572514,-0.018304996,-0.024364175,0.052758433,-0.023087116,-0.037262894,-0.0461464,0.089057595,0.008432017,-0.0450172,-0.014362341,0.062588096,0.08355956,0.046789493,-0.048978698,0.041822758,-0.014706449,0.06736261,0.04702785,-0.006497106,0.012826889,-0.030454533,-0.026904797,-0.034765657,-0.0022510255,0.030710233,0.13807054,0.06973227,-0.01972188,0.0068744314,0.048075024,-0.044546317,-0.042496677,-0.06511241,0.008444188,0.034024693,0.13562024,0.0036427567,-0.028749222,-0.032976292,0.0007645481,0.011651269,-0.036070097,0.02774093,0.122622654,0.05703736,-0.0805524,-0.025523536,0.022813708,0.018884191,-0.045085393,0.12227849,0.09142771,-0.02431351,0.029512396,-0.119050495,1.5499681e-33,0.05182208,0.08279998,-0.0044963383,-0.039316475,-0.01332413,-0.010625677,-0.092465736,0.048825398,0.0019893693,-0.017467376,-0.05561481,-0.02491221,0.040222105,0.048291754,-0.005899482,-0.059648227,-0.043281563,-0.08035307,0.047563307,0.030097142,0.030030122,0.055173032,0.015819749,0.03445191,0.039188746,0.005100642,-0.0058476795,0.0781452,-0.010843186,-0.00273941,0.023079498,-0.119207434,-0.098097935,-0.004255549,-0.012486541,0.005336842,-0.08470863,0.053612452,-0.04807121,0.055802017,0.046836056,0.027491717,0.03120461,-0.041137945,0.047458995,-0.052005462,-0.05243126,0.101361305,0.04527841,0.046654835,0.016855028,-0.025984213,0.106932476,-0.05506346,-0.04520977,0.024872772,-0.012713803,-0.013296975,0.03498564,0.032196548,-0.0028041636,-0.019520728,-0.048357468,0.09690855,-0.011158009,0.042682,-0.05147243,-0.032056358,0.08176803,0.05013106,-0.073387034,0.017737037,0.058270372,-0.017989269,0.007408207,-0.07483638,-0.13495167,0.021769788,0.008504093,-0.0033923844,-0.008013367,0.014555396,-0.0050684996,0.03325977,-0.051777735,-0.004297844,-0.02080255,-0.023565318,0.004736995,0.06760198,0.038130466,-0.051271323,-0.029191552,0.016560927,0.03732545,-2.3511827e-33,0.11496928,-0.10384784,-0.004055745,-0.10289993,-0.09867835,0.08710379,0.02172547,0.004652255,0.078450546,0.019636994,0.052133363,-0.01094319,0.049848434,-0.044431355,-0.033845738,0.008345714,0.02175221,0.054975756,0.02900355,-0.014618609,0.02725939,0.0024986132,-0.0012753011,0.008602543,0.0064920327,0.050511435,-0.04171928,0.002148648,0.03766732,0.03929965,-0.05370982,-0.01724594,0.002754966,-0.07014872,-0.015227209,0.017190065,-0.04603867,-0.03319251,0.018977165,-0.015605727,0.012672546,0.02997868,-0.010014872,0.08471892,0.01539898,0.08905592,-0.08702414,0.030601459,-0.025757777,-0.057582874,0.011320281,-0.058000267,-0.05396398,-0.050365787,0.02147399,0.06758698,-0.011513642,0.027705478,-0.009580986,0.005996623,-0.02570388,-0.049109913,0.028313685,-0.07190803,0.03039568,-0.0005516172,-0.05380239,0.06556005,0.045442116,0.03130123,0.034353685,-0.0031825958,0.0018775592,0.009722183,-0.021410039,-0.051018197,-0.027262786,0.001983409,0.04336604,0.011890336,0.009121806,-0.026919957,-0.005680454,-0.09106509,-0.00965748,-0.046857547,0.021336755,0.10330483,0.015426631,0.013039816,0.013059683,0.033748847,0.011239436,0.002847049,0.016037637,-4.426906e-08,0.03450707,-0.09219634,0.037905894,-0.042941496,-0.020671358,0.08003254,0.06282849,0.011213602,0.03843435,-0.016492033,-0.014694228,0.106266014,-0.008559225,-0.0018137656,-0.05825152,-0.032030232,-0.099146396,-0.011730699,-0.058611248,-0.049456846,-0.0909892,0.022676334,-0.103641964,0.013294362,0.034154315,-0.038189847,0.023835305,0.010426488,-0.051958796,0.014987885,-0.030892469,0.05436708,-0.03212237,-0.057101913,-0.14945316,0.014224955,0.04656245,-0.014193462,-0.06862776,0.020581659,0.04159704,-0.052016,-0.14801978,-0.024958106,0.07324776,0.02999963,-0.030130835,0.005146394,-0.054992925,-0.003218385,0.061026,-0.02555342,-0.00079586456,0.037868947,-0.079163276,-0.01014307,0.0018448957,-0.088159375,0.03768333,-0.05823358,0.022939963,0.03101144,0.19658741,-0.025565576 +1.14.14.178,"This plant cytochrome P-450 (heme thiolate) enzyme participates in the biosynthesis of brassinosteroids. While in vivo substrates include C28 steroids such as campestanol, campesterol, and 6-oxocampestanol, the enzyme is able to catalyse the C-22 hydroxylation of a variety of C27, C28 and C29 steroids.",384,1.0,-0.106505476,0.04571672,-0.05904922,-0.034453105,0.0042217723,0.14020482,-0.089137,0.10227115,-0.02858867,0.02110885,-0.022908412,-0.037979264,-0.06410887,-0.079315886,-0.050263256,0.0492701,-0.03941828,0.07094965,0.019080134,-0.09969887,-0.037889868,-0.02168344,0.021257803,0.014242377,0.029499484,0.04464449,0.011942762,0.06882354,-0.037366565,-0.037414875,-0.06581127,0.015227255,0.027247552,-0.0008824158,-0.026179021,0.062128928,-0.086815864,-0.071956016,0.060890038,0.05316393,0.07667298,-0.035851236,-0.0795208,0.04274556,-0.038330708,-0.044765584,-0.025840776,0.059663896,-0.020084796,-0.055199306,0.027771503,-0.021623384,0.0032352803,0.06746652,-0.034110636,-0.022741862,0.036641132,0.044157576,0.035738144,0.035258524,0.013671178,0.013452485,-0.06079879,0.007246588,-0.0270448,-0.019939177,-0.055545744,-0.015922416,0.0017278845,-0.03305436,0.018186195,-0.06239258,-0.10368031,0.026310166,-0.10683609,0.08722745,0.0010119032,-0.02364825,0.019447833,-0.019371994,0.014744073,0.023747364,-0.0004646615,0.049294095,0.040503222,0.028079499,-0.016085207,0.047118995,-0.022253994,0.05173615,0.009432759,0.039387785,-0.07141791,-0.04973686,-0.11027973,0.07694305,0.0747488,-0.0038335496,0.012135707,-0.024016581,0.074279055,0.06739354,-0.021494014,-0.113652766,-0.038733114,0.034125324,0.009052789,0.009747381,-0.0012965051,-0.07913257,-0.019803423,-0.0039281114,-0.041964013,-0.012107679,-0.06278265,0.07009192,-0.03260355,-0.044060335,-0.014758508,-0.0067307004,-0.019675206,-0.048453256,-0.055367116,0.02142897,-0.047788836,-0.038882338,-0.05367335,3.7739768e-33,0.066139385,-0.0042035016,-0.015699467,-0.02141663,-0.004145042,-0.0009426196,-0.071407676,0.00085980084,-0.06219881,-0.019494962,-0.07161656,-0.090034984,-0.012279295,-0.029871173,0.016894322,-0.028001808,-0.02952804,0.076985344,0.07588261,-0.011956119,-0.011406336,-0.0049702814,-0.08729895,-0.059929606,0.012034851,0.0773457,0.0070690415,-0.0059321914,0.025253909,-0.012036132,-0.060945477,-0.00688629,0.02467887,-0.0151846865,0.020353416,-0.07923623,-0.04193406,-0.03169546,-0.034112476,0.059359267,0.026626037,0.020710284,0.01259438,0.020340225,0.04395495,-0.024403907,-0.090819426,-0.008194031,0.115112096,0.053711526,0.09018331,0.0021464794,0.100164376,0.07192541,0.028091816,0.058108065,-0.03164066,0.015104518,0.008760461,0.03932106,0.08277381,0.069601424,-0.0037271692,0.0054940414,0.07200109,0.019248564,-0.09496952,-0.025583535,-0.016475694,0.08122086,-0.045558985,-0.046347138,0.0803193,-0.0086439,0.07047149,0.061142735,0.017340152,0.06713941,0.04005458,-0.055876505,0.030179681,-0.031345557,0.019897504,-0.007033232,-0.01770856,-0.0074214847,-0.05606632,-0.05437077,-0.019702062,0.06638257,0.098571956,-0.08306816,-0.052709993,0.017170511,-0.04454581,-4.2778704e-33,0.064686246,-0.01586797,0.014080367,-0.1263652,-0.05148149,0.06537855,-0.057000007,-0.102910645,-0.022318631,0.05978766,0.05028528,-0.011154025,0.006983268,-0.02941349,-0.0058683013,-0.04625535,0.03971237,0.08467744,-0.1000253,0.007069356,-0.058452558,0.04334736,0.024106609,0.012170024,-0.013988501,-0.0191773,-0.03214941,0.036380675,0.10033677,0.04430165,0.025095431,0.03548117,-0.03592632,-0.00846586,0.03621276,0.052796617,0.04649193,0.054640293,0.089312896,0.0556689,-0.039321255,-0.008017912,-0.0061991336,0.049823362,0.059112288,0.025332926,-0.047939662,-0.04606204,-0.06617114,-0.014671431,0.027354335,0.049578678,-0.043716628,0.027702017,0.010279753,-0.026102083,-0.0047888756,-0.06743545,0.04806617,-0.08798378,0.026548503,-0.041514385,0.009562011,0.034834493,-0.0014512776,0.09683782,-0.085351996,0.07275414,-0.03909305,0.080104835,0.034152072,0.0022513627,0.023404945,0.08963725,-0.0036467551,-0.009131497,0.053837102,-0.040645123,-0.0061628413,0.021338986,-0.009592208,0.017121619,-0.041622445,-0.09778238,-0.03677525,-0.059846893,-0.033228114,0.08890008,0.040986314,0.034096725,-0.016861223,0.025860649,-0.06845032,0.070515804,0.08760117,-3.6980474e-08,0.004056924,-0.054766197,0.023045432,-0.0021216439,-0.029696556,-0.024393218,0.022779206,-0.0040095993,0.085324705,-0.08156139,-0.049673844,0.054613013,0.04787322,-0.038364314,0.083286464,0.03216142,0.017935408,-0.026534203,0.026461724,0.037775684,-0.06059134,0.005221672,-0.025184125,-0.013380631,-0.014196991,-0.09079876,0.029652108,0.07810888,0.025241729,0.062319264,0.08993289,0.06393914,-0.06608441,-0.0016315278,0.04474435,0.027886117,-0.029482402,-0.011802378,0.0010841973,-0.01597851,-0.063805036,-0.06804441,-0.08134532,0.05607629,0.024620324,-0.008512029,0.04611617,0.059279155,0.027872697,-0.052315447,-0.04427351,-0.00052847946,-0.01194248,-0.11868889,-0.045534074,0.020066816,0.060485832,-0.009941931,-0.039416347,-0.097961254,-0.063728414,0.0050358432,0.1996596,-0.0023302878 +1.14.19.79,"This cytochrome P-450 (heme-thiolate) enzyme, characterized from the plant Arabidopsis thaliana, catalyses C-3 dehydrogenation of all 3beta-hydroxy brassinosteroid synthesis intermediates with 22-hydroxylated or 22,23-dihydroxylated side chains.",384,1.0,-0.1275099,0.015844433,-0.058848504,-0.037808735,0.033666242,0.08660677,-0.05974751,0.07427286,-0.027604766,-0.0010615865,-0.0011716492,-0.039577432,-0.066181175,-0.1060392,-0.030415684,0.0055410946,-0.065812424,0.059749518,-0.00437364,-0.09963136,-0.0034450733,0.028309496,0.021718914,0.021576684,0.044712298,0.030043023,0.055212066,0.049318023,-0.058685813,-0.029606385,-0.071744554,0.033705585,0.06266011,0.02792215,-0.039052427,0.10270408,-0.09732311,-0.09981562,0.008015587,-0.009507304,0.079716355,-0.012763372,-0.06887966,0.041657638,-0.08603599,-0.05371115,-0.06752525,0.04708852,0.013481584,-0.044375785,0.0094051,-0.0017553235,-0.03256759,0.03493711,-0.031079898,-0.01490026,0.05579592,0.03516983,0.013073704,0.015092799,0.008171163,0.023806652,-0.035485454,0.00011677844,-0.0018346553,-0.0022459927,-0.050008185,-0.049026664,-0.025145695,-0.043247547,-0.040855687,-0.076039754,-0.09551819,0.024663998,-0.08755229,0.10525113,0.0101996865,0.008546548,-0.019635523,-0.022690682,0.026983865,0.018043287,0.0139865745,0.08040375,0.013192152,-0.0034109794,-0.050974414,0.069999464,-0.00012125854,0.0040845918,-0.03708696,0.06819783,-0.06770568,-0.03148394,-0.06516191,0.15198803,0.025305102,-0.05077979,0.045579117,-0.014489613,0.0928799,0.091360286,0.0025624114,-0.11348354,-0.010181371,0.04266736,-0.012188832,0.03466316,-0.001620973,-0.06936155,-0.0076289056,-0.021407027,-0.02048194,-0.041921984,-0.08605517,0.06626226,-0.054759998,-0.03764608,0.024649965,-0.025935566,-0.010316133,-0.04684845,-0.04259292,-0.049349554,-0.08069235,-0.017580701,-0.08750959,4.5347975e-33,0.06705658,0.037951846,-0.03723914,0.0059172637,-0.02429858,-0.001833325,-0.039233662,0.05583167,-0.09078052,-0.0023199904,-0.06874304,-0.06640137,0.008749288,-0.05552599,-0.0058737635,-0.041164417,-0.050530378,0.055680193,0.07970195,0.016552018,-0.01780039,-0.013734613,-0.066531725,-0.06637663,-0.0052240733,0.06672414,0.036623273,-0.025116315,0.05455839,-0.026812956,-0.04953648,-0.00055589544,0.032514296,-0.047524046,0.032347422,-0.087771125,-0.07286887,-0.008320416,-0.0022076552,0.08483198,-0.007835716,-0.000108453896,0.048284274,-0.022712242,0.040157884,0.056873813,-0.073840864,0.010793706,0.027796945,0.07635919,0.083228186,-0.007499643,0.12881254,0.07657628,0.009130222,0.023663271,-0.019820899,0.04345262,0.0030851644,0.04517879,0.063920565,0.08212097,-0.014792394,0.044340666,0.019443791,0.0434949,-0.121258356,-0.023444522,0.015173916,0.10611411,-0.036297534,-0.039102193,0.07105875,-0.012142152,0.06943874,0.03339412,-0.007952678,0.05925463,0.054420862,-0.028300403,0.008250565,0.045460373,0.030423744,0.00044193264,-0.0037756292,-0.027343439,-0.07285141,-0.028494295,-0.0709884,0.040990695,0.08094048,-0.061311424,-0.0033993993,0.0022563078,-0.022611858,-4.8960824e-33,0.08384044,-0.014195194,0.010615423,-0.12612258,-0.03355868,0.010924365,-0.020604247,-0.07548155,-0.0015267832,0.07395289,0.09002898,0.004377961,0.023412442,-0.056856,0.015579876,-0.005417837,0.03436656,0.048002902,-0.08786764,0.0473652,0.0031478764,0.045489017,0.025418554,0.032699574,-0.012771605,-0.021456337,0.017773787,0.049624313,0.069247104,0.022616912,0.013062423,0.025558433,-0.019293137,-0.0058789183,-0.021573484,0.038110536,0.04009226,0.016063394,0.072589554,0.047682934,-0.053836536,0.04781536,0.022580113,0.07300756,0.034515884,0.07309918,-0.061551817,-0.018193228,-0.057044685,0.012799836,0.0070822197,0.032911222,-0.056562472,0.021941436,-0.020649262,-0.01930008,0.018741354,-0.051206887,-0.0030503687,-0.07765708,0.008512598,-0.040363263,0.06756621,0.042942904,-0.010032301,0.10767484,-0.01637115,0.051808987,-0.012143902,0.09414887,0.025249856,0.0068751,0.004478037,0.058611985,0.035013385,-0.012356911,0.052140947,-0.0040839203,-0.0086833425,0.00026681492,0.047898144,0.0009966295,-0.06517633,-0.076164275,-0.008398044,-0.1413488,-0.0498583,0.11042592,0.026211001,0.02356758,-0.023667153,0.052613847,-0.05593037,0.051918298,0.09493828,-3.5958116e-08,-0.012233739,-0.057018008,-0.00808703,-0.012269905,0.0037590652,0.023384742,0.004976158,0.0045306836,0.11429525,-0.07533975,-0.021086138,0.028709617,-0.00020587658,-0.04599204,0.061599456,-0.0247018,0.01723689,0.02837815,0.030363081,0.06408806,-0.047248404,0.04304415,-0.08425498,-0.007248872,0.019238785,-0.08105192,0.0042032455,-0.04389124,0.028019996,0.04749215,0.05255042,0.08663695,-0.050146844,0.00827946,0.013448512,-0.005680248,-0.03967458,-0.0035025966,-0.004555302,-0.04927502,-0.013736806,0.009178183,-0.09570679,0.031031389,-0.023299506,-0.053574592,0.013824318,0.06754728,0.04068429,-0.017994577,-0.045923796,0.010742428,-0.0021825226,-0.13940212,-0.04471204,-0.013004149,0.03763765,-0.020468777,-0.06416408,-0.081799336,-0.031522408,-0.014530703,0.18377239,-0.0013667186 +2.3.1.308,"The enzyme, characterized from the fruit fly (Drosophila melanogaster), acetylates the N-terminal of both alpha- and beta-tubulin. The enzyme acts cotranslationally, and can't act on a preformed tubulin alpha/beta heterodimer.",384,1.0,0.013199739,-0.07882229,-0.057212945,-0.06192406,-0.015641173,0.070979126,0.022929396,-0.016384326,-0.04169843,-0.007900262,0.06456599,0.04770219,-0.078344785,0.05226169,-0.053315878,0.048300613,-0.06002297,0.014936829,-0.016158324,-0.08126797,-0.0029779791,0.02106971,0.002359974,-0.0022781056,-0.006483362,-0.06715056,-0.012909721,-0.032098908,0.013288319,-0.15842082,-0.08970745,0.0065471847,-0.038942784,-0.012395072,0.04624316,-0.064983256,-0.003536222,-0.0464871,0.052228037,0.017245295,0.12851143,0.009842162,-0.031086275,0.0344842,0.021042446,0.0083079515,-0.0025993353,-0.003795443,0.08547931,0.023232121,-0.06008822,-0.094500996,0.011670518,0.07979093,-0.011862343,0.05900418,-0.024414018,-0.040489055,0.07167932,0.027701687,-0.0070582945,0.05178135,0.009031016,-0.05729859,0.07892802,-0.04278054,-0.039506033,-0.052583408,0.01788404,-0.009190802,-0.011646612,-0.06576134,-0.11258473,0.05141249,-0.025165781,-0.003985123,-0.015237413,0.035619404,0.0036868856,0.09381541,0.017082553,0.00663656,0.0046405164,0.07210978,-0.0081755435,0.057402246,-0.04672841,0.01856811,0.030678047,0.06989928,-0.031556353,-0.039134987,0.04218361,-0.040250134,-0.06633584,-0.06318008,0.0042879786,-0.035364747,0.0161462,0.02587046,0.026805803,0.0028195893,0.011240069,-0.0028921163,-0.08830743,0.010650628,0.053498108,-0.019132342,0.034733187,0.030852538,-0.022166912,-0.07212996,0.09986487,0.049522478,-0.08744677,0.0041793925,-0.048330422,-0.012992818,0.033791784,-0.006762068,0.056066897,0.041697167,0.03233459,0.061754733,-0.04514257,0.054445807,-0.14587894,-1.4097628e-34,0.061896585,-0.004428592,0.072017945,0.041699752,0.02656883,-0.008294191,-0.056535084,-0.055419788,0.020588096,-0.050397623,-0.11501942,-0.021177344,-0.0057839137,0.03937242,0.00031144742,0.007757065,0.0020034416,-0.004835896,0.05605038,0.05278915,0.0077928314,0.030108484,-0.07909341,-0.10000547,0.048850387,-0.048852492,-0.07024735,0.070435815,0.0028118119,0.0231815,0.038834825,-0.02356248,-0.039814994,0.11331098,0.04129264,-0.047502954,0.04519899,-0.05410679,-0.0048248037,0.024699973,-0.013261316,0.03327446,-0.00481057,0.0676535,0.014407875,-0.06797277,-0.025506724,0.039177228,0.023152225,0.0020459073,0.020595713,0.014012839,0.080188595,-0.01727771,0.018868629,0.03997101,-0.079288304,-0.0225161,-0.028361732,0.06207684,-0.014409881,0.03803193,-0.04449314,0.0009074113,-0.02136463,0.075960144,-0.06860383,-0.04256718,0.025649589,0.009344213,-0.08486879,-0.020950297,0.05198544,0.0005082959,-0.0005645518,-0.07337961,-0.028338084,0.017654225,-0.019924609,-0.03826143,-0.040218648,-0.008018538,-0.0011200233,0.024283968,-0.06715344,0.01553861,0.11777339,0.01921068,0.032914266,-0.003212254,0.035110805,-0.0039405734,-0.030246215,0.08115894,0.07967239,-8.908037e-34,0.02482228,-0.12185084,0.01061523,-0.04219325,-0.06000892,0.06311803,0.065060236,-0.10172007,0.014850055,0.01604089,-0.03100797,0.08397796,-0.024506072,-0.05412845,0.10021852,-0.029457254,0.0019098853,0.038401145,0.030809885,-0.024072964,-0.05941997,0.074047364,-0.053709008,0.003821898,-0.01166099,-0.0075720963,0.025378136,0.111795016,0.07376093,0.024699537,-0.015846819,0.024877725,0.029154664,-0.016348626,-0.028763022,0.033514492,0.004980548,-0.011668182,0.029030982,-0.012319892,0.02866193,0.016091837,-0.06694463,0.004397092,0.07093917,0.08450774,-0.008397938,0.027443843,-0.019386906,-0.024445483,0.036329616,-0.01601133,0.021179512,0.004059081,0.007824479,0.014475244,0.057248246,0.048970502,0.03685449,-0.012030363,0.024374146,-0.06894911,0.011260302,-0.023026792,0.008075527,-0.006072183,0.041149475,0.03599709,0.0055361064,0.022393942,0.0060738362,0.023676876,0.079134576,0.08714547,0.025813133,-0.007269239,-0.055553764,-0.049251657,0.013470446,-0.060444463,-0.108822286,0.080952786,-0.03679678,-0.022498729,0.021374555,0.013439686,0.0060229534,0.11988734,0.016013537,0.029766014,0.05817412,-0.08128389,-0.09873761,0.03226695,0.018906971,-3.2559125e-08,0.11323468,0.01815127,-0.017365409,-0.024456749,-0.07200655,-0.013646065,0.033684608,0.0051325457,0.10189298,-0.023526208,-0.041674335,0.068107955,0.063141346,0.032048795,0.07051454,0.048887193,0.028372893,0.04209938,-0.037967518,0.037497785,-0.12213358,0.051549625,-0.04517451,0.0029228057,-0.09166247,-0.11342445,1.0919207e-05,0.08650164,-0.10120358,-0.030041657,-0.030039003,0.035592925,0.0014267555,-0.120544046,-0.09867051,0.050953172,0.031620093,-0.07516635,0.077288635,-0.0032444731,0.009837711,-0.08368643,-0.03355794,-0.031036817,-0.01717319,-0.008582088,0.075677544,-0.067528486,-0.010006024,0.0057104924,0.042502508,0.04278153,0.03401053,-0.070322424,-0.06947576,-0.040466234,-0.05230749,-0.09670939,-0.03672213,-0.023360921,0.05235202,0.014681956,0.154409,-0.09541418 +2.4.1.387,"The enzyme, found in bacteria that produce cyclobis-(1->6)-alpha-nigerosyl, acts on the products of EC 2.4.1.24, 1,4-alpha-glucan 6-alpha;-glucosyltransferase. It catalyses the alpha-(1->3) transfer of the isomaltosyl moiety of one substrate to another, resulting in alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-alpha-(1->4)-glucan formation. In addition, the enzyme catalyses the intramolecular cyclization of the product, eventually generating cyclobis-(1->6)-alpha-nigerosyl.",384,1.0,-0.080034815,-0.019008,-0.14094809,-0.002387716,-0.041817717,-0.0041797035,-0.0111866705,0.024068465,0.040110454,0.006513387,-0.0023326192,0.004027035,-0.010620201,-0.011851988,-0.07307596,0.016837215,-0.091406114,0.051885124,-0.059384834,-0.014039041,0.03919696,0.0017080462,-0.067136645,-0.022546675,-0.011919688,-0.029489223,0.057466783,-0.10115804,-0.030359274,-0.036810733,0.023022873,-0.0743653,0.0826214,-0.010900622,0.12769662,0.035818383,-0.039141163,-0.058814425,0.0703383,-0.013958722,0.030468935,0.016725482,0.048214298,-0.003997066,-0.036913197,0.021494966,0.03656751,0.03041629,0.07667905,-0.07617864,0.056340706,-0.09643509,-0.11731861,0.049501393,0.017323637,0.0041792397,-0.11772039,-0.05687113,-0.005634458,0.028112976,0.03243676,0.02889312,-0.0034242007,0.051128186,-0.05896592,-0.07848887,0.08233056,-0.07782872,-0.05311592,8.4824445e-05,-0.07327313,-0.012153007,-0.03353194,0.050510943,-0.06074212,0.05693437,0.033165097,0.0014489923,0.013955616,-0.016671026,0.07370941,-0.030273002,0.06578003,0.03512562,-0.05024909,-0.03077696,0.025973676,-0.015482947,0.031781998,0.0665039,0.08493749,0.020383896,0.025144344,-0.055171564,-0.0020377922,-0.020501254,0.03947074,0.050618473,0.11440917,-0.018152386,-0.0078378795,0.007654934,0.04149423,-0.028218225,-0.057584103,0.036412667,-0.026024744,0.07898555,0.06352329,0.044963084,-0.066644646,0.024761232,-0.020062633,-0.011527579,-0.05025906,0.04775515,0.067295745,-0.0028306036,-0.042394456,0.045584768,0.012867892,0.00037043105,0.06919034,0.0664974,-0.095412284,0.106447026,-0.023406537,-1.1194994e-33,0.017284658,0.06091157,0.022605592,-0.036867663,-0.036987912,0.01584431,-0.0657658,-0.03950879,-0.050320975,0.004686127,-0.08275047,-0.007649655,0.044460565,0.06700751,0.014376181,0.09578511,-0.012102277,-0.02345594,0.020386154,0.0046581374,0.018124115,0.043975573,0.008568129,-0.03254016,0.041757047,0.034727287,-0.026716702,-0.012365481,-0.011509055,-0.023754863,-0.10487783,-0.024627123,-0.09511386,0.038071945,0.041212533,0.03250182,-0.0008572602,-0.061611343,-0.0020993191,0.035759345,-0.014326184,-0.049110822,-0.051766414,-0.06739318,0.12568407,-0.012629734,-0.031327903,0.036986157,-0.00053191377,0.07937298,-0.026625305,-0.056793675,0.06892581,0.040904094,-0.020209003,0.005585458,-0.022074396,-0.04012085,0.03268847,0.0009803936,0.04535888,0.107355796,0.00511614,0.0053983605,-0.058690287,-0.007823043,-0.017875135,-0.0033750618,-0.08949694,0.044208925,-0.039137598,-0.043710165,0.042594768,0.014511182,0.018772732,-0.029972984,-0.017845375,-0.0030302545,0.04065996,0.027010404,-0.0036092142,0.016627014,0.048475254,-0.04229093,0.022063555,0.050968148,-0.05871809,0.0060637295,-0.06539592,0.08486478,-0.0016985044,-0.07804674,-0.1768131,0.1043164,-0.023561517,-2.6683154e-33,0.15028255,-0.123516336,0.021419745,-0.0642318,-0.0009858294,0.0205356,0.00199542,-0.030116644,0.0033352885,-0.016998107,0.0020247826,0.010307945,0.006337525,-0.03851264,0.042221144,-0.16686319,0.013097286,0.1038143,-0.060632225,-0.00025648926,0.023313332,0.0055279327,-0.020027274,-0.030599173,0.036823317,-0.08290211,0.014874812,0.10445155,-0.00473868,0.03088208,-0.016241852,0.018289596,0.03234545,-0.037474517,0.023353694,0.09453234,0.010136279,-0.016721278,0.04086533,-0.013399618,-0.004259452,0.097161524,0.010314326,0.022068655,0.0911119,0.09522565,-0.016563307,0.02543131,0.0078398315,-0.02006358,0.06458276,-0.011899196,-0.0014704493,0.049882494,0.025477089,0.025139403,0.040964838,0.033349853,-0.032006916,0.014484852,-0.058339708,-0.0769996,0.022729402,-0.07311595,0.05405086,0.103406675,0.060919754,0.08888216,0.024173182,0.049190994,0.030341832,-0.025276747,-0.075277284,0.004014962,0.004953372,0.042443786,-0.057361867,-0.078004286,0.01759951,-0.076252736,-0.034009,-0.014940148,0.058777403,0.02168203,0.013690488,-0.07008469,0.0729136,0.06944695,-0.007367197,0.04354728,-0.018629072,-0.024792774,0.006972238,0.04108868,0.009870328,-4.664289e-08,0.020750329,-0.010513459,-0.016413754,-0.055550925,0.058215775,0.05654271,-0.07788333,-0.027641702,0.026106285,-0.066630095,-0.019878438,0.0706458,0.016196175,0.039541632,-0.009280598,0.03100785,-0.06955713,-0.06707267,0.042170227,0.018038837,-0.062291574,-0.04868131,-0.08239533,0.022484617,0.005853826,-0.13890885,0.05517439,0.07240474,-0.030834014,-0.012713682,-0.000939024,0.011873568,-0.07096802,-0.01034366,-0.03958463,-0.019638939,-0.023042204,-0.08297376,0.04527179,-0.033236668,-0.0084837405,0.0017152934,-0.02148263,-0.010378732,-0.04336222,0.012344227,-0.045101207,-0.014487069,-0.07478429,-0.0123406965,0.03072649,-0.043376293,-0.07430853,-0.053924486,0.012754647,-0.07528819,0.028068967,-0.056913976,0.02253123,-0.007814256,-0.013344132,-0.030131819,0.13869584,0.006815781 +2.4.1.388,The enzyme from the bacterium Paenibacillus polymyxa belongs to glycoside hydrolase family 94. It has a much lower activity with 4-O-beta-D-glucosyl-L-arabinose.,384,1.0,-0.017595975,-0.06224334,-0.04859616,-0.10718389,-0.043191537,-0.010892541,-0.055801634,-0.009223617,0.015504064,-0.029652141,0.021052748,0.024435218,-0.0013182196,0.010871978,-0.049165554,0.01597035,-0.009850412,-0.045053586,-0.015226,-0.03702135,0.08107562,0.050648164,0.034985512,-0.04040004,0.042187482,-0.02917171,0.041158233,-0.039644867,0.0009756628,-0.028473869,0.04019489,-0.021777792,0.0543441,0.019861301,0.06991805,0.0975223,-0.06775976,-0.041689698,0.0910832,0.02917166,0.049847063,-0.029752575,0.07008522,-0.0420625,-0.061660618,0.029807234,-0.0435043,-0.009575493,0.05653494,0.04660232,-0.07431002,-0.083204485,0.0111608105,-0.030610833,0.05868646,-0.0004499302,-0.010492345,-0.030399928,-0.018605141,0.0008124003,0.05473722,0.010931343,0.017552039,0.043100905,-0.11318841,-0.0073476085,0.10972497,-0.09419426,-0.024523975,-0.09265295,-0.063682504,0.047623713,-0.035090897,-0.013692236,-0.006519945,-0.0136666605,-0.0142242545,-0.031292815,-0.009222053,-0.044104423,0.040252216,-0.021432022,0.08805414,0.07996423,-0.04824075,-0.043875966,0.047427215,0.0014956394,0.058910284,-0.009398087,-0.00650219,-0.041758973,0.026417611,-0.020548536,0.023086362,-0.0023088031,0.003153336,-0.058622688,0.00071540376,-0.014471228,-0.00317086,0.016784728,-0.01048626,-0.075013295,-0.06755465,0.050937407,0.011600674,0.08866661,0.024868738,-0.012628148,-0.033446975,0.083143465,0.00091000856,-0.011524266,-0.054829802,-0.02571811,0.08585588,-0.04334553,-0.06392492,-0.04734512,0.0018543464,-0.011483639,0.06471688,0.020511195,-0.058283035,0.060260303,-0.13942938,4.905454e-34,0.044041533,0.021075062,0.053270195,-0.07951398,0.008026782,-0.012457232,-0.06315141,-0.012206843,-0.07283084,-0.05268318,-0.07781878,-0.060234215,-0.023474207,0.13381092,0.04569983,0.057838045,-0.0028659035,0.018531434,0.06917221,0.02178766,0.029139405,0.054700322,-0.0056304852,0.0044330754,0.067826375,0.115537815,0.05483097,0.04315521,-0.02030133,-0.009713045,-0.038792726,-0.0527849,-0.10176587,0.0067576957,0.027023064,0.044111684,-0.09861441,-0.04303522,0.037458688,0.052252427,-0.026515432,0.01966954,0.035435677,-0.09108949,0.07280939,0.03862376,-0.018594999,0.0019037016,-0.025479918,0.086627826,-0.009107865,0.017457142,0.020374313,0.025242034,-0.069171004,-0.013316034,0.0023492335,0.07131702,0.0150469355,0.05737989,0.053227335,0.07746766,-0.006770547,0.04134024,-0.019717734,0.025668593,0.033992898,-0.023767525,-0.046025284,0.06256211,0.010756072,-0.027944457,0.086787604,0.0001321046,0.04766783,-0.07171872,-0.013003262,-0.057548426,-0.007299486,-0.015217638,0.0025379227,-0.01408749,0.020679437,-0.026478192,-0.111109786,0.020423116,0.012104709,0.014190254,-0.056885917,0.044853117,0.010771359,-0.07576249,-0.038941547,0.07171219,-0.019785278,-2.4657414e-33,0.123595834,-0.08232707,0.10360129,-0.082205065,-0.012509446,-0.008671738,0.11962442,0.008182571,-0.018329475,-0.0063136164,0.10009069,0.008310322,-0.023701522,-0.03097757,0.036370564,0.020975096,-0.01358732,0.0396697,-0.042232372,0.0073096734,0.016318321,0.07058808,-0.012226938,-0.025889209,0.07558195,-0.0037621919,0.021252949,0.12835456,-0.06686318,-0.017352225,-0.073757544,0.06661489,-0.037342314,-0.07409676,-0.03637133,0.04430537,-0.08018213,-0.04106855,0.020690355,-0.029772015,0.028424613,0.07279215,0.061292637,0.08352274,0.00026519503,0.07514599,-0.06994383,-0.041891076,0.019972553,-0.057799507,-0.040700614,0.036206678,0.06319366,0.050970487,0.08452931,0.06271584,0.012474887,0.027373288,-0.094861686,-0.054181825,-0.08213327,-0.0038923086,0.043788888,0.10455809,0.031853028,0.10144977,-0.02179767,-0.005357736,0.040093202,0.010354139,0.010217182,-0.013754524,-0.028875593,0.07033892,-0.0057767355,0.041831248,-0.13917191,-0.0017271122,-0.012206689,0.021023672,0.05595404,-0.030556677,-0.05355749,-0.00840261,0.022125917,-0.1150778,0.05827215,0.08504087,-0.008834141,0.0037382646,-0.013160411,0.025056517,-0.029391423,-0.007559741,0.03291436,-3.2940576e-08,0.023921015,-0.07120884,0.046006363,-0.105343014,-0.0018331201,0.026325474,-0.0150833335,0.044992812,-0.03717818,-0.050127864,0.011156163,0.055825647,-0.017859425,0.013582603,-0.032224916,-0.029808413,-0.11487823,-0.025777504,0.009502602,-0.0080005005,-0.11907978,-0.0071462593,-0.09391614,0.068274885,-0.03692914,-0.02388389,0.034794934,0.025732666,0.0064916303,-0.0047995276,-0.0010299095,0.05126462,-0.062393025,-0.069153346,-0.07444429,0.00020616646,-0.0066697057,-0.0038541367,0.051656336,0.037607867,0.02908542,-0.045015592,-0.047563888,-0.00044170851,0.023077201,0.026526924,-0.03736162,-0.035389185,0.002131914,0.025423108,0.046069305,0.037075385,-0.047110047,-0.0046215644,-0.077274464,0.0024132556,-0.07900974,-0.07079072,-0.039831508,-0.04222456,0.036424555,-0.048069507,0.16449505,-0.059512753 +2.4.3.1,The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.,384,1.0,-0.010004428,-0.06310756,-0.070787385,0.035052888,0.027333735,-0.0080871815,-0.017007725,0.011427267,0.062494148,0.022465998,0.015580096,0.1076609,-0.05159991,0.0219088,-0.06996625,-0.03535726,0.04227208,0.040626936,-0.03610191,0.030923296,0.09958505,-0.044489115,-0.016151235,0.025810272,0.098154604,-0.022885092,0.013943645,-0.06008862,-0.025608646,-0.052683253,-0.014968637,-0.05382268,0.064302444,-0.011269931,-0.007029565,0.022961747,0.034606826,-0.0140373185,0.009235503,-0.03045123,0.034334105,-0.008378162,-0.00073463825,-0.03027091,-0.067606196,-0.0032770035,-0.0075315526,0.052980106,0.07246311,0.05141669,-0.00046766983,-0.092084095,-0.05789487,-0.033733264,0.0572207,0.08048353,-0.0362212,-0.0637247,0.048301846,0.081356965,0.030957267,0.028891558,0.035343613,0.06780656,-0.03708045,-0.11162831,0.050824217,-0.033498224,-0.039602432,0.026713906,-0.030051526,-0.017625283,-0.03569146,-0.04354325,0.07598296,0.017434772,-0.03575814,-0.009221539,0.08392843,-0.024543257,0.06055593,-0.015414483,0.08724898,0.026268722,-0.056811184,-0.028058393,0.06332186,0.015092511,0.030997913,-0.020954786,0.017125795,-0.048862007,-0.02497578,-0.023343695,-0.045448016,-0.06735572,0.09103441,-0.036683444,-0.013312435,-0.031844083,-0.013967267,0.00065769005,0.069900945,-0.027256062,-0.06291111,0.0836222,-0.020209718,0.025434256,0.052610256,0.032084394,-0.0041785613,0.021599868,0.05048237,0.0066058813,-0.08194938,0.05066179,-0.005252522,-0.06750135,-0.051723424,-0.020208318,0.036370285,-0.017790388,0.051345512,0.039160207,-0.043802787,0.12563711,0.022857808,-5.2189506e-34,0.096832395,0.074228205,0.048968993,-0.03419941,0.0126355635,-0.041280717,-0.04460938,-0.019189304,-0.017849164,0.038982954,-0.016740814,-0.047949612,0.030917794,0.11180968,0.013468323,0.0936084,0.046534624,-0.044956166,0.05202131,-0.010376417,-0.016567342,0.020848803,-0.021290088,-0.03038688,0.098663576,0.051612455,-0.074039266,0.09380999,0.115719035,0.032849114,0.049902845,-0.06897709,-0.089629486,0.026349679,0.055988718,0.049816057,-0.031350724,-0.072436705,0.05181853,-0.014886537,0.013952781,-0.03340949,-0.04191835,-0.020634511,-0.024600172,-0.0033822092,0.021521427,0.008424934,-0.015293498,0.08267069,0.022248736,-0.039634608,-0.004707549,0.010111864,-0.038507693,0.077865966,-0.046427965,-0.04498251,0.0015528257,0.07182992,-0.048881497,0.025536273,-0.0022272717,0.006382926,0.048957873,0.028776519,-0.06036454,-0.016244106,-0.059209943,-0.01856103,-0.028218111,-0.06525407,0.070331134,0.027338952,-0.042247787,-0.051257588,0.041017603,-0.036751326,0.023561774,-0.015769096,-0.026474513,0.07242348,-0.022474138,-0.061266005,-0.016968625,0.013666456,-0.013091192,-0.06542118,-0.052730754,0.0019665195,-0.04715908,-0.015667096,-0.04215952,0.05572634,-0.04643323,-2.9835121e-33,0.118188664,-0.1436242,0.099006206,-0.03426304,-0.056074753,0.021674896,0.031515576,-0.06766418,0.05889534,-0.04524626,-0.0062529068,-0.030740332,-0.03787263,-0.06202128,0.009331139,-0.022093939,-0.06340719,0.08367412,-0.067810185,0.011264581,0.007570717,0.010881515,0.047808792,-0.037056644,0.019391699,-0.07048956,-0.003757246,-0.0038406735,0.0041095344,0.04920937,0.020357583,0.0012318784,-0.06138078,-0.088310346,-0.02295204,0.054756768,-0.10961734,-0.030676795,0.028711233,-0.039481103,-0.014749946,0.059232734,0.005930432,-0.006417358,0.10279551,0.053519957,-0.07151783,0.041355345,0.02622443,-0.08023589,-0.021214377,-0.025969569,-0.00234508,0.12711258,0.03141247,0.07668723,0.063725404,0.053413,0.0039319703,-0.049900968,-0.04501911,-0.017283525,0.022128744,-0.045800768,0.06773978,0.020801201,0.0072725588,0.014372464,0.06616467,-0.038365714,-0.0066670305,-0.052331284,-0.044544715,0.06647932,0.012238333,-0.011895704,-0.14557444,-0.046467222,-0.036926348,0.0057881773,0.040811826,0.05561964,-0.0070021925,-0.048580408,0.016313575,-0.047131043,0.053123612,0.16914225,0.0070774425,0.05386029,-0.038473137,-0.013740629,0.010827092,0.043406043,0.08016329,-2.7891149e-08,0.06851584,-0.013390259,0.024374235,-0.14937665,-0.05326848,0.0026622335,-0.023829564,-0.023765221,-0.044533785,-0.017255453,-0.02326164,0.08649717,-0.024769671,-0.024525555,-0.051783707,0.09495329,-0.04938959,-0.014462591,-0.0144350305,0.048159957,-0.08678875,0.0070711365,-0.071540944,0.04553242,-0.032112967,-0.06595894,0.0680663,0.049181677,-0.12314606,0.014667437,0.030288193,0.0587161,-0.06935379,-0.045347374,-0.03191909,-0.015037059,0.0007806827,0.008511105,0.0559469,0.012963916,0.007109643,-0.05494106,0.004865516,-0.031615097,-0.058342673,0.04033148,-0.009446612,0.016835488,-0.066194,0.09348078,-0.04753305,-0.026763588,-0.12080944,-0.06628475,-0.085690945,-0.03757057,-0.023310643,-0.02986393,-0.015820453,-0.0619574,0.02098936,-0.025325283,0.10144171,-0.035281718 +2.4.3.2,"The enzyme recognizes the sequence beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl (known as type 1 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids [1]. When acting on gangloside GM1a, it forms gangloside GD1a [2].",384,1.0,-0.041725524,-0.08093386,-0.0827309,-0.0034360518,-0.05025575,-0.052577913,0.0031429084,0.03811924,-0.037036806,0.045254648,-0.012085933,0.09878074,-0.02913751,-0.002658267,-0.0914926,-0.049185243,0.060465697,0.006121432,0.014514617,-0.018900521,0.07841764,-0.051526867,-0.016562909,0.0053500477,0.0696515,-0.024272513,0.020582566,-0.04127054,0.00078480993,-0.06366888,0.009671895,-0.07043966,0.09191052,0.03775413,0.012714257,0.026251404,0.032476906,0.025415685,-0.042354703,-0.01482477,0.033994082,-0.017446958,0.035026636,-0.034520376,0.0019011041,-0.080778964,-0.08124842,0.063629635,0.09398943,0.0297885,0.009507223,-0.06648344,-0.04929423,0.009207672,0.04120914,0.005950027,-0.053091727,-0.036848083,0.06013967,0.03557589,0.016799176,0.011660146,0.019657928,0.0026193073,-0.015633535,-0.07608343,0.0680137,-0.05470201,-0.03332049,0.056809116,-0.00228227,-0.02461969,-0.035133664,0.005878862,0.0109541705,0.043961905,-0.05321361,0.021466818,0.065602526,-0.032763097,0.059413165,0.037276965,0.105173595,0.07175446,-0.09152721,0.055804253,0.03734559,0.02596548,0.030567465,-0.02897214,0.004331918,-0.037150364,-0.0020259826,-0.021536067,-0.07432162,-0.02915563,0.09631487,-0.036896173,0.03426083,-0.045928802,-0.0032128291,-0.02731712,0.031256065,-0.017559335,-0.09845913,0.062249858,-0.050373774,0.052552905,0.07798605,0.0070230137,-0.043041036,0.06402572,-0.0015906916,0.008706,-0.094926864,0.024201749,0.022049835,-0.0451472,-0.021461826,-0.012218682,0.04723317,0.009357632,0.052915953,0.015156211,0.004864908,0.06241236,0.032365337,1.0350686e-33,0.077459425,0.014247375,0.039750762,-0.03472155,0.0054292562,-0.007088137,-0.058690276,-0.015470204,-0.005035899,0.027282646,-0.039008126,-0.050369844,0.015593234,0.10275751,-0.05796067,0.13310699,0.03576707,-0.09614384,0.049269173,-0.060165375,-0.05431029,0.035134178,0.012263596,-0.033857465,0.08794716,0.04228349,-0.047569886,0.056606527,0.10810753,0.022319663,-0.017800732,-0.03780951,-0.08423231,-0.000109601904,0.019786766,0.061367456,-0.007851988,-0.051947657,0.059535112,0.012175102,0.032022383,0.0038066737,-0.025828889,-0.062106654,-0.01986348,-0.0002988922,0.015911188,-0.0055342056,-0.02772592,0.066808805,0.02117686,-0.01671377,0.0019571774,0.037787203,-0.039568257,0.08072269,-0.019827018,-0.025762856,0.012161492,0.08467697,0.047223713,0.04408309,0.015769083,0.012178805,-0.014897506,-0.019351859,-0.04531789,-0.012151896,-0.051800933,-0.021607004,-0.047850896,-0.06707159,0.04249596,0.053044092,0.024205659,-0.07094561,0.08231257,0.012340708,-0.019922499,-0.012858167,-0.065004215,0.044050094,-0.029993756,-0.03210354,-0.057882793,0.0622863,0.0036260886,-0.13219227,-0.06139811,0.0067216894,-0.08462821,-0.016118601,-0.035397265,0.07454869,-0.024577823,-4.300549e-33,0.05936962,-0.098203845,0.10073824,-0.029110407,-0.028192515,0.02662621,0.014873939,-0.028210685,0.0847981,0.021876061,0.02921218,0.024455557,-0.048037905,-0.057827577,0.032267403,-0.018913908,-0.054867167,0.0670463,-0.071113795,0.052537877,-0.039230842,0.043221556,-0.0005536305,-0.022877432,0.025972674,-0.04017885,-0.015265628,0.047438126,0.03053015,0.019322272,0.005904337,0.044380378,-0.054698326,-0.10257161,-0.052446045,-6.1398634e-05,-0.07119174,-0.041019633,0.03958918,0.0011094386,-0.025736652,0.08072041,0.021687813,0.0074958852,0.1042382,0.08611859,-0.03099466,0.062275466,0.031220205,-0.056961883,-0.030868335,0.0045681703,-0.0064023174,0.13185635,0.08531344,0.04629456,0.07554746,0.07191457,-0.053606115,-0.01703092,-0.022291288,-0.014500197,0.003144036,-0.040118765,0.09761252,0.0248233,-0.0034420881,-0.0069951457,0.08877976,0.0070372177,0.031676006,-0.054802403,-0.035029195,0.05883316,0.022033583,-0.012633353,-0.15731455,-0.03918046,-0.02810842,-0.042094883,0.060708128,0.09116107,-0.02553886,-0.0077885087,0.038396183,-0.020576281,0.03855652,0.14962327,0.0159932,0.05229822,-0.028918786,-0.03214266,-0.031202395,0.038079,0.0005850112,-3.8166483e-08,0.072406925,-0.05205617,-0.025416605,-0.1481103,-0.060333285,0.013042852,-0.05731613,-0.0038827893,0.022017168,-0.04187861,-0.03490803,0.07394926,0.004438928,-0.016574549,-0.080909,0.10158113,-0.027634269,-0.028295618,-0.03615308,0.050196838,-0.10288149,-0.027831662,-0.07213722,0.040654194,-0.028817398,-0.1005071,0.04257157,0.033369463,-0.07360562,0.012562877,0.008922708,0.07442636,-0.024614912,-0.06661081,-0.015378564,-0.0006723715,0.004526843,0.026519964,0.12666918,-0.02501617,0.037132896,-0.01729535,-0.01192145,-0.028412117,-0.081152774,0.008405819,-0.0043165707,-0.0006807379,-0.063047245,0.04329164,-0.069055915,-0.006163026,-0.09451118,-0.104953125,-0.053546526,-0.046980094,-0.048954196,-0.032221753,0.041080493,-0.08899929,-0.018474812,-0.07141049,0.06736002,-0.0030058685 +2.4.3.3,"N-acetyl-alpha-D-galactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.",384,1.0,-0.026922995,-0.08442992,-0.10993086,-0.012709259,0.028867573,0.010946482,0.053000886,0.019461783,0.04271585,0.029337766,0.021664064,0.031679828,-0.037804577,0.03777196,-0.036274225,0.014214227,-0.01644573,0.02252057,0.08512203,0.069642745,0.04228249,-0.0023198498,0.03540404,0.015088463,0.015560753,0.04548465,-0.0036432766,-0.046055302,-0.0030733678,-0.088155165,-0.039491735,-0.016153812,0.051872343,0.0344957,-0.028928155,-0.01501433,-0.06307758,0.03330207,0.005244083,0.023352653,0.0029906614,-0.032630727,0.024055311,-0.04212995,-0.015340021,-0.010359958,-0.060156483,0.012371568,0.07199824,-0.0023526726,0.04611346,-0.002937095,-0.037609812,0.12416595,-0.02397295,0.08415489,-0.0676393,-0.04929014,0.032930307,-0.012612632,0.06561023,0.037876196,-0.0215798,-0.06489886,0.08609596,-0.077522315,-0.0033303208,-0.08867353,-0.007947754,0.04716988,0.0026939118,-0.02262682,-0.038786475,-0.023939699,0.050772026,0.0019107371,0.014580483,-0.002710937,0.09318684,0.009825138,0.0007139463,0.03931665,0.008697812,0.11213732,0.041209992,0.010817452,-0.053257633,0.04279745,0.07191734,0.013692298,-0.004702847,-0.072843015,-0.011091306,-0.061860595,-0.0059352815,-0.059910998,0.019676922,0.028661221,0.010419118,0.07090885,0.055148333,0.010398896,-0.065154314,-0.066848844,-0.0695919,0.041298524,0.018722646,0.008373271,0.01642784,-0.023169478,-0.102616735,-0.09930416,0.054051004,0.05603679,-0.114419065,0.08349512,-0.013222998,-0.07600029,0.042472728,-0.09295641,0.02964524,0.045281466,0.033231698,0.057306148,-0.00019578796,0.063145615,-0.022240978,2.9495447e-34,0.030964322,0.07142346,0.067709975,-0.059892084,-0.027213935,0.03425842,-0.065800846,-0.051395733,0.05324591,-0.10228448,-0.10993754,-0.027674448,0.07429733,0.020896224,-0.03994975,-0.07226688,-0.029320572,0.06110505,0.057260524,-0.062180657,0.0059891692,0.064426415,-0.07632194,0.034630165,-0.032683305,-0.031382278,-0.037139274,0.0853721,0.08727794,0.0036433411,0.06944262,0.022244241,0.00300874,0.031215787,-0.013406262,0.033932157,-0.023506457,-0.03287202,0.01038266,-0.02204878,0.016403517,0.074899286,-0.031686615,0.03666453,-0.02414892,-0.06886159,-0.03950089,0.034818724,-0.033672176,0.037299167,-0.008478362,-0.056707505,-0.037154827,-0.059350636,-0.019516451,0.035745863,-0.054943442,0.040610846,0.013832827,0.033963844,0.023217829,0.0050416156,0.017966395,-4.02743e-05,-0.047383636,0.07143276,-0.055344254,-0.008290978,0.036417235,0.044084202,-0.04313984,-0.015617901,0.079358734,0.09474818,0.008747335,-0.064937815,-0.057548072,0.019846503,0.008337035,-0.050744332,-0.041284688,-0.0053286133,-0.048264805,0.10191906,-0.077728346,-0.02500447,0.04250313,-0.1103095,0.00017183149,0.019638894,0.007956744,-0.08187708,-0.043972127,0.042735886,0.037006475,-1.692964e-33,0.018954819,-0.09158508,0.07333951,0.016612427,-0.029790163,0.08026696,0.03201486,-0.12062023,0.036035616,-0.029576892,0.089173704,-0.02506398,-0.007309107,-0.043618113,0.044858065,-0.038919855,-0.02424372,0.013344084,-0.008726295,0.009069627,0.036499172,0.03424356,-0.05537542,0.015103688,0.005876255,-0.0012195334,0.0046980907,0.00941862,0.038837545,0.088639095,-0.050075814,0.029066212,-0.026206842,-0.05482412,0.0268173,0.06355104,0.037718363,0.026978223,-0.08031371,-0.0012332989,-0.0050923787,0.038538113,0.07563102,0.1408588,0.054390777,0.06742333,-0.0012862596,0.01918384,-0.011835701,-0.046288922,-0.024928112,-0.061646193,-0.007988413,-0.0053334194,0.035452932,0.10458633,-0.013413059,-0.0076682875,0.0068149795,-0.03298168,-0.018382048,-0.02825169,0.014957866,-0.09665461,0.021419335,-0.05460255,-0.079985805,0.10604629,0.087919265,-0.10796412,0.04370942,-0.003804129,0.13257366,0.06104307,0.042687457,-0.12070471,-0.05969624,-0.06923226,-0.0001302227,-0.101173915,-0.062317576,0.0544363,-0.0063639306,-0.044218823,-0.067964055,-0.004212288,0.0899858,0.0905422,-0.07323975,0.02723178,-0.053099457,0.01652856,-0.01709977,0.04413764,0.027615253,-3.2869004e-08,0.065376,-0.04081932,0.028572055,-0.036530603,-0.03846603,0.02996332,0.025103921,0.019195689,-0.017942946,-0.07453581,0.005772399,0.14207925,0.049065083,-0.053306825,0.014790439,0.029595494,-0.019913346,0.014951088,-0.07104629,-0.017738711,-0.1057667,0.026376981,-0.013709203,-0.08709428,0.009830727,0.031130116,0.004794429,0.07414732,-0.07128602,-0.048845693,0.04193763,0.01306564,0.008834229,-0.10212282,0.02849728,0.090629436,-0.005620576,-0.05827707,0.049105886,0.012378742,0.012944176,-0.0031735937,-0.053801175,0.046081983,0.013458221,-0.004360827,-0.018392783,-0.0037550938,-0.1110471,-0.036795147,-0.055712305,-0.02858422,-0.00783991,-0.050360262,-0.013099809,-0.0012933029,-0.049458697,-0.063727066,0.013810142,-0.019092543,0.022265056,0.0022867178,0.09222207,0.05438011 +2.4.3.4,"The acceptor is Galbeta1,3GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid. Lactose can also act as acceptor. May be identical with EC 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase.",384,1.0,-0.005214514,-0.08780146,-0.09889438,-0.026079813,0.080613546,-0.02269428,0.027366253,0.01902404,0.043366637,-0.04840282,0.07077636,-0.003708132,-0.084900424,-0.008216803,-0.0522363,-0.00412946,-0.046508588,0.010000673,0.0100383395,0.007498055,0.03826008,0.039364032,-0.00976279,0.048637066,0.0396822,0.0011241578,0.0267709,-0.04772067,-0.037630744,-0.12134774,-0.02906332,-0.09338501,0.08417737,0.01739618,-0.016630474,0.017767733,0.010585818,-0.07792714,0.03652262,-0.012708554,-0.02052429,-0.07157218,0.06645194,-0.003651436,-0.030775169,0.005535976,-0.037904445,0.0697597,0.03277576,-0.008656197,0.029532915,-0.06558329,-0.0068143355,0.05895955,0.021216229,0.06510216,-0.073915996,-0.05213455,0.025554525,0.0318538,0.023370033,0.016917827,0.026848963,0.0149950115,-9.3383656e-05,-0.03651147,0.051106423,-0.12883526,-0.035425484,-0.023926845,-0.050175566,-0.059304,-0.039262112,-0.042039577,0.07225624,0.044995762,-0.0061093513,0.0127661275,0.08286607,0.041805282,0.00032553024,-0.04295034,-0.0160983,0.056970254,-0.015217116,-0.053742774,-0.014314234,0.020743452,0.01847909,0.014076934,-0.051248223,-0.06450995,0.031452138,-0.041238952,-0.024803862,-0.01359126,0.047017224,0.0020082234,0.06935942,0.0059023057,-0.044860423,0.027399642,-0.029032335,-0.040947404,-0.07377987,0.06677723,0.030404374,0.04297768,0.032914992,-0.046232834,-0.057005633,-0.087049425,0.04267997,0.06374944,-0.09098035,0.060922623,0.015778301,-0.12950598,0.07154219,-0.04696007,0.029654948,0.027649699,0.07991092,-0.0076366425,-0.018686661,0.07360914,-0.07220179,1.2954762e-33,0.0036584705,0.09137035,0.07030377,-0.047255185,-0.0014268714,0.021152968,-0.088964954,0.0027721552,-0.0076425783,-0.05307245,-0.1157596,-0.061962336,0.035872277,0.04905057,0.010179831,-0.018639572,0.010318302,0.06262117,0.03470881,-0.006398659,-0.016646884,0.07250908,-0.057529807,0.013289465,0.050982136,0.036892686,-0.020829989,0.041867033,0.10199095,0.008236398,0.10139186,-0.039526228,0.00403575,0.050713476,-0.02439557,-0.0043550534,0.03838282,-0.0032549412,0.018355208,-0.037525214,0.015793813,0.011680443,-0.032844435,0.030643702,0.0032746734,-0.01700626,0.0020642336,-0.02447645,0.063664444,0.04714664,-0.027877418,-0.023434399,-0.036150772,-0.053049568,0.012398725,-0.025222376,-0.061657477,0.111622445,0.018231628,0.055369776,-0.0027473299,0.11729411,0.0016465114,-0.016663032,0.00581295,0.030621497,-0.023213075,-0.08207551,-0.034450777,0.047272835,-0.0540044,-0.044423893,0.06277461,0.09012901,0.043890882,-0.056120668,-0.035583425,-0.015859595,-0.00011850957,-0.004432648,-0.1250869,0.0016134047,-0.0037546742,0.04601949,-0.10520862,-0.017351275,-0.04380906,-0.07683552,0.027447348,0.046701852,-0.022566976,0.016490748,-0.04974876,0.07317404,0.03148689,-3.4782073e-33,0.09153042,-0.09859756,0.079644464,0.0025037488,0.015975306,0.04606217,0.008220883,-0.024859738,0.13954434,-0.03638164,0.09888046,-0.0028553193,0.009741005,-0.053281657,0.07176286,-0.040615667,-0.02184522,0.04908353,-0.061415236,0.064601205,0.053390455,0.05355703,0.0018748286,0.010950237,0.009940782,0.017189912,0.017063798,0.023932237,0.00031604237,0.018899936,-0.0438929,0.01861428,-0.03287407,-0.07355199,-0.05137918,-0.018330378,-0.08156331,-0.0033242654,-0.03540716,0.031569444,0.0018515951,0.057418596,0.0074291234,0.08917918,0.043308243,0.048661873,0.038085077,0.031215644,0.039226532,-0.047982927,-0.059354965,-0.008460705,0.023832068,0.056922544,0.10573025,0.09852059,0.04026987,-0.018665958,0.0187885,0.012207829,-0.005443216,-0.028338283,0.06310684,-0.06951152,0.05386322,-0.05122794,-0.09664331,0.0017070279,0.059807897,0.0129176285,0.066828094,-0.07053772,-0.003697976,0.10511608,0.061160047,-0.059285376,-0.12564136,-0.0843234,-0.021149758,-0.07389344,-0.020496357,0.060325064,0.03144062,0.0070799594,0.04641975,-0.05653773,0.025403501,0.043809216,-0.0066472986,0.029755212,-0.05472993,0.0077587925,-0.05635417,0.046131954,0.03660432,-4.5964732e-08,0.055305276,-0.02702596,0.007937839,-0.1104867,-0.00649627,0.05340481,-0.04310167,0.014680538,-0.012010045,-0.029427491,-0.030578455,0.15506682,0.03138488,-0.12801608,0.03193732,-0.01471815,-0.014386709,0.027642068,-0.022330048,0.04038305,-0.0816046,-0.019722052,-0.03497877,-0.11110586,-0.030760044,-0.03717845,0.02439203,0.0852569,-0.072993755,-0.057900656,0.06255275,0.050582428,0.013327228,-0.047125302,-0.01979516,0.041299243,-0.04855563,-0.021840394,0.012157309,0.036267787,0.04902316,-0.04104905,-0.059363816,-0.011318123,-0.07006935,0.03962406,-0.0070821494,-0.032027498,-0.0774944,-0.028345913,-0.032532938,-0.056676958,-0.0405683,0.02498554,-0.016781788,-0.044927035,-0.044840906,-0.05427495,0.023210935,-0.043219008,0.07592869,0.0051072706,0.1482101,-0.011341207 +2.4.3.5,The beta-D-galactosyl residue of the oligosaccharide of glycoproteins may also act as acceptor.,384,1.0,-0.019815966,-0.09098379,-0.045219254,0.04098612,0.04197687,-0.013410515,0.03645345,0.018128488,0.051639266,0.020380342,0.05159823,0.12136152,-0.053133126,0.053227104,-0.06642593,-0.039771277,0.04616356,0.034529917,-0.024829688,0.05015605,0.057876352,-0.011931793,-0.01847595,0.008043011,0.086776264,-0.03995961,-0.018338831,-0.045049217,-0.0026794893,-0.06010373,-0.042037014,-0.06925654,0.06730044,0.0033642761,-0.012791512,-0.004204668,0.016921816,-0.024695374,0.003391038,-0.03566882,0.012001289,0.008607314,0.02012346,-0.019424424,-0.08251737,0.007775958,-0.0069775255,0.045579784,0.07190963,0.043614984,-9.375277e-05,-0.09100386,-0.069716066,0.0011204368,0.04873436,0.08727675,-0.052628506,-0.0673746,0.05474003,0.03965201,0.00628146,0.01619739,0.027927577,0.056183763,-0.04497173,-0.11561201,0.06657003,-0.02037536,-0.055401284,0.06008834,-0.0007082012,0.005730519,-0.04233413,-0.026954556,0.08071332,0.040086117,-0.05376135,-0.030462103,0.092798986,0.0029236854,0.03725165,0.016492082,0.08567152,0.00039406845,-0.055958144,-0.035952453,0.03485498,0.019920973,0.0083083445,-0.025909709,0.012916486,-0.056787327,-0.0070830984,-0.055294283,-0.022177044,-0.101212755,0.118646994,-0.026860267,0.02924394,-0.035463795,-0.045538735,-0.016219506,0.059175905,-0.021286784,-0.058058586,0.05823451,-0.029934255,0.0025821691,0.064761035,0.04072726,-0.022653485,-0.015431219,0.06464571,0.0073811086,-0.08580659,0.016008414,-0.009909078,-0.074191295,-0.03692476,-0.05499239,0.020661332,-0.0030976594,0.0480206,0.02171864,-0.038992044,0.091176815,0.019760212,-1.6227918e-33,0.068737306,0.040351517,0.062420532,0.0043286704,-0.002445858,-0.027372058,-0.03003355,-0.03272613,0.0065911394,0.0041366243,-0.0475683,-0.050609052,0.022479892,0.13410509,0.009570845,0.11520053,0.022552794,-0.03190287,0.04436368,-0.025827624,-0.01107378,0.009170845,0.0011618015,-0.039708078,0.073558986,0.023168145,-0.07471315,0.09217074,0.10425022,0.033217046,0.09232826,-0.060449593,-0.06367923,0.031460803,0.05470393,0.054857403,-0.0082715945,-0.062498897,0.058875546,-0.032326795,0.029080411,-0.031229049,-0.07632659,-0.018133368,-0.003655633,0.031683244,0.014087229,-0.020488843,-0.041419767,0.06917333,0.022014499,-0.04051228,-0.06523704,-0.010816333,-0.031193938,0.0820809,-0.03863851,-0.028697902,-0.03893192,0.08438849,-0.02975317,0.040461637,0.00011055175,-0.009939154,0.026369484,0.027804345,-0.062258482,0.0029191794,-0.0543016,-0.030186448,-0.010046078,-0.06841567,0.03975695,0.046673752,-0.057199005,-0.070134915,0.029222982,-0.015342395,0.039175704,-0.023633188,-0.022643885,0.06081292,-0.04225378,-0.022276593,-0.043316957,0.011438473,0.001574469,-0.08632677,-0.026245555,0.035793945,-0.04256093,0.002903524,-0.04595954,0.053155452,-0.04263178,-2.5239261e-33,0.13182922,-0.13585716,0.10365005,0.004334643,-0.024607744,0.031849965,0.04098678,-0.04203948,0.08797164,-0.04032105,0.026701862,0.0019588673,-0.044119228,-0.039638035,0.024280367,-0.061830003,-0.082284346,0.09724922,-0.078115985,0.030168168,-0.019662363,-0.03125901,0.044776622,-0.04585138,0.041733775,-0.035933614,-0.034359425,-0.0051474096,0.0029970647,0.062944174,0.016253283,0.026833339,-0.077520184,-0.103581406,-0.02119865,0.0009229805,-0.10672488,-0.03029612,0.013988238,-0.03888625,-0.0044133845,0.06571081,0.02510715,0.0026864568,0.10322507,0.02613159,0.0062203715,0.022038173,0.035420015,-0.068083175,-0.014034565,-0.04595129,0.007379395,0.10481607,0.03358478,0.09892514,0.07807798,0.039222814,0.021622997,-0.043913398,-0.050936434,-0.006924758,0.021117285,-0.04685399,0.032893557,-0.009645241,0.010522606,0.003644708,0.09201728,-0.044093903,0.0043839817,-0.06276345,-0.026640002,0.048481464,0.020670837,-0.016088445,-0.16683541,-0.023373326,-0.03929616,0.012233638,0.00062428263,0.077281214,-0.020091692,-0.0075237183,0.06425551,-0.045303978,0.033905134,0.12040759,0.0039868653,0.024524022,-0.053032853,-0.008637648,0.023145104,0.065115236,0.07776468,-2.6032893e-08,0.046084285,0.000914261,0.016366504,-0.13805129,-0.05917056,0.015021253,-0.014645346,-0.031967785,-0.05550688,-0.0036042563,0.007637711,0.10124544,-0.038594484,-0.045692965,-0.063901015,0.07983476,-0.08601351,-0.02889204,-0.008584585,0.053900376,-0.10514687,0.014564871,-0.03561476,0.0370732,-0.06812604,-0.039128274,0.047361016,0.06909704,-0.11813114,-0.0014832161,0.04854326,0.0528174,-0.073428586,-0.056348104,-0.0017015387,-0.030185422,0.011917235,0.00235068,0.06603155,0.012843038,0.020043189,-0.024891611,-0.0040687923,-0.03938419,-0.04651896,0.040066604,-0.015400454,0.034226064,-0.09219402,0.07268452,-0.05137606,-0.03263228,-0.12881723,-0.030216318,-0.06584641,-0.03241081,-0.035631105,-0.014102118,-0.027016493,-0.044870026,-0.0033127393,-0.043173835,0.09416206,-0.015357999 +2.4.3.6,"The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1 [2].",384,1.0,0.0028386435,-0.085849755,-0.09033111,-0.0015034165,-0.07248411,-0.03758976,0.013921597,0.019253025,-0.011826403,0.035370834,-0.019356335,0.07677281,-0.034271866,-0.006830843,-0.09295626,-0.013617176,0.049842954,-0.047272447,0.026954288,-0.00050489104,0.044285618,-0.05676534,-0.013240867,-0.012867486,0.06439121,0.0030146441,0.018989574,-0.04636642,-0.0265806,-0.033365794,0.051085535,-0.07083565,-0.010252033,0.025617722,0.031674813,-0.018871482,-0.030550214,0.036970474,0.018721381,0.017022442,0.034187067,-0.06706899,0.016331557,-0.0102363955,-0.013350119,-0.03945276,-0.06863834,0.014820321,0.09516551,-0.0028976162,-0.02565939,-0.06934412,-0.038630012,0.030203445,0.012762448,0.023577584,-0.07569145,0.017463688,0.022953821,0.060547743,-0.022201063,0.022040328,0.015097183,0.02094653,-0.010873904,-0.06356148,0.03068137,-0.10754745,-0.056246307,0.05735432,0.023352252,-0.053329114,-0.010143942,-0.016012298,-0.0014168449,0.023638723,-0.027037736,0.041165285,0.064648174,-0.054909196,0.06371266,0.042223882,0.07433882,0.087354004,-0.038276,0.06569864,0.045621168,0.052160814,0.0017753121,-0.026702758,0.016228411,-0.071478225,-0.022691913,-0.0106835095,-0.054228667,-0.054993186,0.09388174,-0.060173437,0.052790027,-0.047805417,-0.030771606,-0.010346245,0.029540062,-0.042036876,-0.05684945,0.08946266,-0.005337008,0.019624293,0.08225804,-0.014166012,-0.04895496,0.09074662,-0.016401652,0.027553065,-0.039257057,0.0092244735,0.03839513,-0.016314542,-0.011980183,-0.029328357,0.07163187,-0.0032471174,0.063982785,0.00514765,0.0046753786,0.09384646,-0.008604865,2.2415482e-33,0.062616065,0.021975132,0.01760465,-0.041343935,0.03151961,-0.020272378,-0.05738979,-0.008942594,0.0012824411,0.035209034,-0.0067797913,-0.09468356,0.0020841523,0.13304952,-0.021025509,0.11940816,0.04645817,-0.095445305,0.08743321,-0.08777994,-0.06985767,0.057843987,0.007526388,-0.015091295,0.041385517,0.08141812,-0.07154549,0.057202246,0.10250985,0.024266055,-0.02892304,-0.06209405,-0.054523047,0.009986662,0.01069257,0.07225123,-0.033227555,-0.06022515,0.07406994,0.054185126,0.070036516,-0.011365883,-0.016590627,-0.042700615,-0.0250197,-0.014483722,-0.028058035,-0.0026596517,-0.0005599134,0.0169936,0.013040905,-0.024898399,0.04925208,0.023968222,-0.021241736,0.083771266,-0.030761033,-0.016379302,0.04597687,0.08590165,0.04064851,0.039981414,0.018691419,0.009172931,0.021126179,-0.05919226,-0.060607124,-0.04678988,-0.10040864,-0.030326556,0.0028461996,-0.09413272,0.09266888,0.008642376,0.049047355,-0.04819953,0.060915504,0.015786754,-0.035931658,-0.03557753,-0.039851848,0.031737603,-0.0010318953,-0.029665068,-0.029670574,0.06621293,0.009074248,-0.11493671,-0.022014046,0.014077577,-0.09428656,-0.030391205,-0.032999262,0.026159463,-0.040363204,-4.7222584e-33,0.020200847,-0.068403386,0.08963564,-0.02471489,-0.029923676,0.041806314,-0.006292992,-0.037230723,0.04928635,0.07429318,0.00858208,0.04375004,-0.042143032,-0.079881005,0.025079168,-0.023534777,-0.07242927,0.059265967,-0.03275982,0.023206014,-0.019949134,0.092583515,-0.013247888,-0.0037427742,0.06364317,-0.03252814,-0.007684811,0.05493886,0.02348134,0.0026646953,-0.013566592,0.045039587,-0.061389253,-0.13705292,-0.008678605,0.018722123,-0.062636726,-0.04875199,-0.008742107,0.016005553,-0.029865133,0.06473544,0.04660522,0.00817418,0.13156316,0.03385595,-0.02456277,0.011847647,0.0019389883,-0.020178048,-0.05115689,0.005657526,-0.023876768,0.091394536,0.073731594,0.05265472,0.04263146,0.05601906,-0.0069940994,-0.046205617,-0.029442344,-0.032693118,0.0037809904,-0.02842071,0.13728642,0.03574334,-0.0036955646,0.029931167,0.07733259,0.019880125,0.018047493,-0.02921049,-0.036317907,0.078902744,-0.00461824,0.023274584,-0.15981442,-0.04834389,0.020462215,-0.029388431,0.05619989,0.01804387,-0.012382611,-0.03203319,0.020246424,-0.057603214,0.0094303405,0.15227206,-0.030584088,-0.0036267398,0.012635206,-0.07495554,-0.044784054,0.05275463,0.0083297165,-4.164129e-08,0.07896719,-0.09524376,-0.01676452,-0.09370443,-0.005818326,-0.05568701,-0.05963655,0.005724082,0.045801207,-0.02158095,-0.08379153,0.04360929,0.028784627,-0.033437032,-0.101108044,0.13426521,-0.003134088,-0.009551647,-0.023385597,0.04556922,-0.07309179,-0.00418647,-0.034139328,0.019190785,0.002246005,-0.12227607,0.05331401,0.076543175,-0.09749279,-0.008738798,-0.021234853,0.065361716,-0.01039403,-0.07212962,-0.020850714,-0.035957687,0.005888175,0.0024297098,0.1461118,-0.009209852,0.014185974,0.0012386536,-0.0075492123,0.005763084,-0.06260761,0.015604782,-0.008880954,-0.030041935,-0.031007104,-0.032906022,-0.057070814,0.010901606,-0.0516255,-0.09779473,-0.064653546,-0.013758056,-0.049306285,0.027981192,0.065553464,-0.09543921,-0.003019308,0.025407443,0.10595777,-0.028336203 +2.4.3.7,"Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetylgalactosamine only when present in the structure of alpha-N-acetylneuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.3.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.",384,1.0,-0.02079377,-0.1435443,-0.11206027,-0.0071277632,0.05640748,0.06562399,-0.012775121,-0.016398262,0.028020952,-0.037513744,0.025027975,0.025257533,-0.05685437,0.014586171,-0.07144561,0.05766647,-0.0728144,0.014891262,0.018089637,0.023980184,0.020015249,-0.061753247,0.009228539,-0.05324526,0.035485473,0.046497773,0.032805324,-0.08949591,-0.004444,-0.1282028,0.018046482,-0.06906579,-0.00799468,-0.026976846,0.10080796,0.033782244,-0.027680768,-0.024047595,0.019763345,0.025608849,0.046901565,-0.021202166,0.0015700933,-0.0329498,-0.0063418513,-0.024869425,-0.053045485,0.04297979,0.07281035,-0.010515717,-0.011652384,-0.060139563,-0.010122404,0.0632383,0.013498518,0.08309197,-0.056697596,-0.01959377,0.05878678,0.129852,0.11223563,0.03393501,0.033019245,-0.018403538,0.0070500555,-0.036916036,0.11111691,-0.055364083,-0.039898504,0.02345548,-0.09653404,-0.030561928,-0.014581911,0.011378014,0.041608028,-0.005031284,-0.03540015,0.030338943,0.05058489,-0.021496458,-0.012690714,0.04398552,-0.055059824,0.06116042,0.017888147,0.01633161,-0.009504604,0.00888808,0.04203003,0.08348907,-0.057386763,-0.065219626,0.11149967,-0.070202574,-0.04111662,0.011423561,0.037283074,0.009846414,0.0275701,0.012915835,-0.005843548,0.08602665,-0.0010923799,-0.06520505,-0.0581251,0.062966354,-0.070554644,0.07312365,0.045678012,0.03757271,0.003630151,-0.02240725,0.004970428,-0.024615616,-0.077696115,0.06410105,-0.04297115,-0.052220743,-0.014106299,-0.01797654,0.029828766,-0.040489875,0.05101702,0.028471142,-0.020452818,0.08450945,-0.027760666,3.4694595e-33,0.057773054,0.075307354,0.036208745,0.016375225,0.02373879,0.008159242,-0.09719555,-0.020647373,0.007774444,-0.06240076,-0.06703784,-0.038719498,0.004060506,-0.00056187424,0.032878883,0.11869851,-0.013648277,0.026555886,0.019315109,-0.018044828,-0.009020611,0.040545244,-0.08849668,0.005154442,-0.00055116677,0.055291705,-0.03627084,0.020146828,0.07049425,0.0013188168,-0.0642522,-0.009138475,-0.04675089,0.045111913,0.020700948,-0.046591338,0.04747803,-0.11635256,0.052433338,-0.0020175958,0.058054432,0.06499045,0.024590911,-0.00487113,0.010581118,-0.058464747,0.02697806,0.015358958,-0.021176627,0.026302809,-0.043563534,-0.05758808,0.07724754,0.0128642,-0.0142349005,-0.0070619234,-0.105969794,-0.017386276,0.059555147,0.037459504,0.014873413,0.0015384771,0.05546307,-0.04943195,0.002486241,0.012826528,-0.036466736,-0.0029260912,-0.007823349,-0.027537411,-0.06199301,-0.035112415,0.015418533,0.06759083,0.03175311,-0.087282546,-0.03656156,0.042117335,0.07970976,0.00045385153,-0.020904388,0.04012343,0.0491432,-0.05388264,-0.02670311,0.017371394,0.025242476,-0.06757529,-0.05170387,0.020306563,0.02538042,-0.07858383,-0.06564452,0.11007143,0.036651783,-4.5730808e-33,0.13487053,-0.10568832,0.07377744,-0.04894569,-0.056974582,0.052582808,-0.0034257716,-0.028861139,-0.032659963,0.020516312,0.06881133,-0.015088386,0.035729527,-0.06379986,0.08421525,-0.091742486,0.11121995,0.050425276,-0.025627237,-0.032118805,0.024508176,0.02198754,-0.032949403,0.050485652,-0.020877205,-0.0035606606,0.0062513314,-0.0044285236,0.025026798,0.11098493,-0.022494933,0.023956778,-0.0912898,-0.046507876,-0.021335844,0.031533606,0.036334492,0.01934025,-0.05193181,0.02445592,0.04755514,0.054428387,-0.02101603,0.046193052,0.031084776,0.046275545,-0.015668618,0.01593492,-0.020203732,-0.020073941,0.0679573,-0.017826684,-0.046496727,0.031180533,-0.047599558,0.05996091,0.030621648,0.048409943,-0.01157065,-0.06112468,-0.07089602,-0.010079421,-0.023077274,-0.07181455,0.036233615,0.034159947,-0.013352106,0.099892676,0.0638106,-0.06303069,-0.025494805,-0.024244795,0.0895378,0.056890853,-0.007932448,-0.08676332,-0.0662111,-0.10746713,0.030014807,-0.10597753,-0.01255284,-0.0014524162,-0.0023483222,-0.078378186,-0.0013451391,0.0069232853,0.093880795,0.09708945,-0.047912776,0.017457705,-0.027565515,0.029712984,-0.09566288,0.0603762,0.0029319692,-4.7290904e-08,0.09701567,0.029269004,0.016789932,-0.07684405,-0.0105893705,0.0062606754,-0.08074043,0.07944113,0.05200247,-0.050282776,-0.038828824,0.09851523,0.030169526,0.050795756,-0.03210881,0.025365662,0.005234852,-0.017179457,-0.022733744,0.006553787,-0.07723135,-0.011699908,-0.0273533,-0.007918899,-0.04267884,-0.10676013,0.08227479,0.07069114,-0.02418863,-0.030911775,-0.035390932,-0.005459504,-0.062278803,-0.03467537,0.0017258031,0.019753251,0.059905708,-0.091267556,0.023251873,-0.022902712,0.020024223,-0.016905034,-0.07083208,0.039802957,-0.022288432,0.021806225,-0.009595237,-0.008628754,-0.07009879,0.016339933,0.031100245,-0.063503586,-0.061501365,-0.10781794,-0.07818352,-0.07133544,0.0009781064,-0.020626454,0.04714698,-0.010229361,0.010759627,-0.03216204,0.12655595,0.0032858509 +2.4.3.8,Gangliosides act as acceptors. ,384,0.99999994,-0.03402235,-0.03686014,-0.031843852,0.006949272,-0.05255484,-0.082503766,0.04199679,-0.024242079,-0.005125874,0.020541063,0.03041063,-0.027730528,-0.03791626,-0.043294404,0.008860507,0.023261743,0.030067908,-0.025976002,0.023208506,0.04010323,-0.09288495,-0.08476399,0.019903528,0.022412052,-0.051930636,0.061428126,-0.08670755,0.029653182,-0.006550085,-0.06814746,-0.00027649285,0.0065535516,-0.040907215,0.07667554,-0.05979197,-0.009986074,0.022749962,0.07588123,0.06357702,-0.0051598996,0.036841422,-0.050467804,0.039495748,0.0030172674,-0.05262202,-0.020156989,-0.05992573,0.02239791,0.041228686,-0.09719284,0.025315775,-0.018076494,-0.02145058,0.055819716,-0.0774565,0.011107422,-0.045003638,-0.033140805,0.065711394,0.0064289044,0.012776875,0.036527008,-0.051633283,0.03627553,-0.021442581,-0.00018757333,-0.074138716,-0.039442647,0.01860619,0.09130356,0.06359081,-0.017033065,-0.0544829,-0.024164988,-0.03775224,0.033882566,0.01751287,0.033664655,0.06786049,-0.07285518,-0.046470355,0.017249752,0.028921166,0.055433538,0.0350009,0.029869597,-0.015274826,0.051579345,-0.014299707,0.03310503,0.044700988,-0.05450948,0.016251467,-0.052811284,-0.08997844,-0.062268384,0.019550718,-0.026807688,-0.003013394,0.04616921,-0.044041645,-0.04471218,-0.042649895,-0.007087801,-0.05681578,0.014219937,-0.034758635,-0.058611717,0.0058521,-0.025759423,-0.091823354,-0.0348531,0.011505402,0.05925038,-0.029120421,0.01964241,-0.045247547,-0.0024561216,-0.011557733,-0.09399559,-0.029277934,0.053586435,-0.03441236,-0.014046142,0.021583248,0.024601463,-0.05456878,-2.3570104e-33,-0.013069234,-0.009823761,0.010956791,-0.10172115,0.008287187,-0.02482227,-0.08131428,-0.031331025,0.0455348,0.048824962,-0.038381014,-0.051813792,-0.012332931,0.044256512,-0.01150743,0.041185733,-0.022264116,0.014866253,0.013751515,-0.08620884,-0.051704623,0.11650678,-0.040204406,0.0043180315,-0.036004044,0.016376512,-0.036236078,0.049219884,0.06786978,0.0563553,0.08753546,0.007949313,0.028945541,0.032578666,-0.023429302,0.111275956,0.005114628,-0.032680534,-0.049322452,-0.093372546,-0.004086162,0.0425481,-0.119925655,0.030549817,0.008317594,-0.005652357,0.014706293,-0.056454025,0.049243443,-0.00714949,-0.023034275,0.030462893,0.04717327,0.02574274,0.03120279,0.044956174,0.015266941,0.038225777,-0.010736451,-0.002517329,0.08364135,0.033655133,-0.017854948,-0.037745386,-0.0183498,0.059145678,0.028948868,-0.053496327,-0.034509182,-0.03748856,-0.019507218,-0.007107477,-0.022773094,0.07820448,0.01797655,-0.056018993,0.02071682,0.0023523844,-0.03426265,-0.04704745,-0.13249655,-0.03064118,-0.014045605,0.039272774,0.02754858,0.038630582,0.055647522,-0.101010635,0.033006288,-0.024416119,-0.06851296,-0.015671387,-0.018647334,0.10455448,-0.073504545,2.8902272e-35,-0.036330935,-0.0040628063,0.0087338,0.050027676,-0.00447991,0.110454895,-0.05648264,-0.00015802121,0.09900764,0.092108235,-0.058776498,0.0912126,0.02446398,-0.06363539,0.090621985,-0.09506134,0.010181586,0.081448495,-0.053245742,-0.012296753,-0.026036587,0.13539933,-8.224899e-06,0.07227394,0.030392893,0.042812046,0.0028859193,-0.037094507,0.005547436,-0.028085275,-0.0031143308,0.02606901,-0.05387251,-0.11119311,0.020850483,0.020492373,-0.036070284,-0.006748746,-0.031753782,0.021074038,0.008434133,0.042017076,0.010107567,0.10881014,0.0310631,0.008901541,0.036156707,0.09843737,-0.09736827,-0.018198403,-0.06714924,0.046467233,0.033465225,0.043033767,0.06810795,0.056675527,0.026859198,-0.044606153,0.014599988,-0.09075107,-0.01842348,-0.01791752,-0.065032005,0.020665675,0.064808875,0.025518442,-0.024988983,0.025581539,0.09494755,0.015595312,0.087789096,-0.1017281,-0.07779427,0.104690045,0.07465752,-0.0011261102,-0.10617023,-0.10463183,-0.007837842,-0.03082371,-0.07315648,0.03971526,0.07887969,0.0018681012,0.044183742,-0.019331107,-0.017085668,0.003799574,0.022954749,0.10180602,0.06384854,-0.053535987,0.040083535,0.06936948,0.020894246,-1.6641968e-08,0.105183095,-0.0059896503,0.00465006,0.016888916,-0.088540465,-0.039892107,0.0073616444,0.03193882,0.0023386967,0.058085546,0.015907815,0.058035653,0.064031065,-0.0008414427,-0.04155186,0.09345748,0.067164056,-0.05929629,-0.0984744,0.0059695877,-0.07675136,-0.0011340869,0.08234434,-0.040725406,-0.005388743,-0.020346193,-0.04480815,0.01680615,-0.12735246,0.09450303,-0.0011174615,0.03331694,0.03051591,-0.0618629,0.037782513,0.09009388,0.00612793,-0.07410071,0.13509461,0.012980634,-0.017658664,-0.032731608,-0.0021600362,0.014609429,-0.05182684,0.08310674,-0.021017183,0.043613933,0.013218869,-0.020987207,-0.006764486,0.005993914,0.03241134,-0.03143699,-0.08009991,-0.006749101,-0.06743975,0.054529645,0.07167942,-0.06949657,0.084673844,0.03310853,0.057402506,-0.030963328 +2.4.3.9,Lactose cannot act as acceptor. ,384,1.0,0.03591135,-0.108776845,-0.050580632,0.028637163,0.026479349,-0.034734286,-0.021679245,0.02910376,-0.02804195,-0.033293553,0.015007806,0.024075119,-0.09479385,0.051182278,0.0017091957,0.005671968,0.0074790213,-0.015786951,0.0059362603,0.04526612,0.066877976,-0.015254383,0.017578827,0.0063775913,0.042319003,-0.03592607,0.024444671,-0.06066932,-0.052080356,-0.08004118,-0.062534146,-0.120176986,-0.0070160935,0.029153088,0.02543351,0.018701768,0.035953075,-0.025103265,0.011134524,-0.08232938,-0.017749723,-0.03567374,0.029047105,-0.0008554222,-0.015173047,-0.011339623,0.021846218,0.004564855,-0.03456525,-0.013792344,-0.0922234,-0.033798426,0.022456488,-0.0006214653,-0.011200938,0.064957865,-0.024419473,-0.031964485,0.006536894,-0.014484374,-0.029811751,-0.013275421,0.032891423,0.04307885,0.039616983,-0.03925204,0.004698884,-0.050084095,-0.108728275,0.018742807,0.0012339416,-0.031250056,-0.03548192,0.021991944,0.087668106,0.044623323,-0.008131213,-0.014986065,0.08628599,0.1364457,-0.11489387,-0.080917634,0.016556863,0.042879492,-0.013941574,-0.07214836,-0.013883474,0.025136841,-0.048573494,0.014941459,-0.066037185,-0.0059654745,0.060630277,-0.04253714,0.059358627,-0.058907486,0.020826451,-0.014566254,-0.01937123,-0.03547791,-0.07297879,0.026011202,-0.009335744,0.0014207955,-0.053129677,0.033110853,0.014984521,-0.036681816,0.01967507,-0.020453809,-0.03612881,-0.012098259,0.11081326,0.0465777,-0.08655616,0.06693328,0.0002263402,-0.12528977,0.013975492,-0.011928152,-0.07891408,-0.0057234853,0.035119813,0.04252028,0.00059331895,-0.0027220952,0.05946746,-1.3012422e-33,-0.031351384,-0.03322903,0.068378374,-0.08221384,0.06335325,0.021242715,-0.049307555,-0.020702159,0.033076067,-0.009810951,-0.008858637,-0.039217256,0.055465337,0.0015819493,0.062538564,0.06529354,0.053908445,0.03541213,0.030955061,0.01966414,-0.03643991,0.037310086,-0.06445543,-0.0107683875,-0.08891429,0.0034406998,0.006518168,0.055865634,-0.018607985,-0.0047696056,0.05680996,-0.07669989,0.010192457,0.12160285,-0.003209038,0.022652429,-0.0073228506,0.026097042,-0.042597026,-0.0053451145,-0.05383201,0.028949026,-0.02191494,0.033091996,-0.0036404713,-0.016248679,0.047937542,-0.07517996,-0.06283549,0.0065136105,0.0028970095,0.0069713104,-0.06344288,-0.012567674,0.06355136,-0.012207635,0.012813312,0.112531826,0.012426114,0.024046049,0.008673601,0.050608665,0.02238479,-0.02265888,-0.019607754,0.057282764,-0.022770058,-0.056022543,-0.0066372687,0.07322756,-0.057426147,-0.041594587,-0.021086205,0.052476637,0.009932802,-0.09833515,-0.0031807567,0.014444699,0.044857994,-0.021113837,-0.034456432,-0.08778541,0.021077089,0.08401187,-0.081731394,0.029122695,-0.09125996,0.0014121888,0.04490494,0.05213651,0.06965278,0.0015327589,-0.022867195,0.03339139,0.093929015,-7.0363315e-34,0.07206203,-0.06270791,0.03250427,0.009118879,-0.007599531,0.039757356,0.03164776,0.007630263,0.14213021,-0.09696799,0.095164284,0.019174326,-0.026046831,-0.0015805204,-0.03145022,0.045584448,0.0013148854,0.076042436,-0.035816424,0.04557011,-0.01637372,0.1558048,-0.049470372,0.06671499,0.028400116,0.08265764,-0.035198618,0.016878301,0.007252375,-0.009529221,-0.0097246645,0.043541647,-0.034724515,-0.095048234,-0.041208606,-0.05390875,-0.12420596,0.009510158,-0.048944008,0.029242303,0.01646423,0.096995436,-0.01544853,0.055782393,0.023254264,0.03729776,0.06175687,-0.057659026,0.025826689,0.008644741,-0.051824998,0.0015570492,0.043504126,-0.011721278,0.09808902,0.100279056,0.07057374,-0.09695751,0.033182375,-0.0131110195,-0.008021913,0.00091048324,0.044619866,-0.07638107,0.039594695,-0.017540775,-0.11454387,0.015404268,0.07140901,-0.018234897,0.09901655,-0.02647672,0.059336226,0.115658365,0.020791275,0.009410816,-0.10444536,-0.012982167,-0.018378612,-0.067468435,-0.054649666,0.08294741,0.011966454,-0.031239877,0.12115208,-0.048024178,-0.031574078,-0.04571882,-0.007871198,0.038337536,-0.015665382,-0.06519324,0.018627102,0.038486563,0.04612626,-1.6296411e-08,-0.0012062583,-0.053640112,-0.018225767,-0.034384236,-0.06309224,0.058365647,0.01373101,-0.07894281,0.01853499,0.02572569,-0.046496507,0.14395988,0.00352137,-0.01076258,-0.019153683,-0.0010300757,-0.012406106,-0.053850587,-0.025549198,0.07855581,-0.16077188,-0.028836854,-0.07024735,0.00037707834,0.022233162,0.0057029664,-0.0018937584,0.063468926,-0.0010858112,-0.025250588,0.036856625,0.046167187,0.01745196,0.04221482,-0.04123721,-0.0005815057,0.01075294,-0.01469081,-0.05086124,-0.029426344,0.05376493,0.02389882,-0.056013577,-0.024814442,-0.05361582,0.068649374,0.005678786,-0.013022045,-0.07937554,0.03472866,0.020556547,-0.0007730687,-0.011981407,0.03730149,0.06516892,0.011501087,0.013863905,-0.04842175,-0.01813354,-0.024993068,0.10114123,-0.04453812,0.1773994,-0.05971486 +2.4.3.10,"Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-beta-D-glucosamine. The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl residues, but more slowly.",384,1.0,0.017471725,-0.13988203,-0.091850616,-0.0027538263,0.03303591,0.05509229,-0.022418309,0.0046438905,0.05108442,0.012783988,0.040687196,0.1069128,-0.06764852,0.08137683,-0.07886241,0.025908483,-0.03639047,0.0032079753,-0.008145543,-0.0014597345,0.026545936,0.003200565,-0.028719448,-0.09038032,0.06215854,0.0025882982,0.114221126,-0.03597983,0.015840312,-0.060733043,0.020221712,-0.06562333,-0.013923124,0.010895516,0.027248483,0.011209423,-0.050398245,0.016129423,0.06976777,0.066780694,0.010067946,0.0125448555,-0.021378199,-0.01197109,0.007846161,-0.03764473,-0.042333487,0.047870636,0.08451734,0.048164792,0.01622874,-0.044868413,0.05122659,0.028042944,0.0003673412,0.07924078,-0.09607067,-0.058896847,0.0030759352,0.08307407,0.032344904,0.054827854,0.030257152,-0.026552526,0.06315481,-0.05008918,0.034686036,-0.04499594,-0.06677512,-0.051061973,-0.062501475,-0.023513626,0.015288439,-0.04496598,-0.019349966,-0.06688547,-0.10308738,0.014714063,0.07262973,-0.042191654,0.031139538,0.010054975,0.028097324,0.072960116,-0.02109785,0.06764466,-0.023192264,0.05593413,0.020296892,0.03849361,-0.023570355,-0.093754925,0.004892266,-0.065424286,-0.010959011,-0.019538704,0.020245854,0.0027889092,-0.030608626,0.014475097,-0.0048815026,0.08333173,0.0008683478,-0.05591786,-0.047271304,0.06424559,-0.0060475683,0.070103996,0.027593467,-0.012091224,-0.03874027,0.0049075834,0.024396732,-0.024511192,-0.067304984,0.08712671,0.014054331,-0.035696834,-0.053954463,-0.03474973,0.051498245,0.019706747,0.013691493,0.07681879,-0.015407635,0.07405935,0.019778656,-1.3002965e-35,0.1008501,0.056639794,0.0050272513,0.017661488,0.037026625,-0.012457266,-0.078329585,-0.015996587,0.042264994,-0.016780844,-0.0760468,-0.028354643,0.008377577,0.031144856,0.029380225,0.13109767,-0.018911703,0.0079612695,0.102154896,-0.030944208,0.010645955,0.027282057,-0.009628778,0.02950841,0.01479511,0.05970025,-0.04010044,0.0751854,0.068738006,0.0012588466,-0.014720311,0.0016675536,-0.029522223,0.0539703,-0.00012477276,0.009855703,-0.06268415,-0.05389604,0.0036467684,0.018020995,0.09141661,0.0022242046,-0.021789825,0.006301645,0.0061945813,-0.07477565,-0.016080325,0.033592217,-0.022545096,0.06142536,0.059466414,-0.020325176,0.06611153,0.009285815,-0.0062907683,-0.02023373,-0.09075176,-0.07295746,0.015080814,0.07752572,0.009213525,-0.06307521,-0.022877619,0.028313093,-0.018264307,-0.003400117,-0.055892598,-0.037614375,-0.046695758,-0.019583287,-0.042012896,-0.04861743,0.037160944,0.059048157,-0.033271544,-0.07498797,-0.033734348,0.028737374,0.041575663,-0.06170338,-0.025180547,-0.0123117305,-0.0039940807,-0.021796033,-0.021390986,0.027587993,0.03799354,-0.1280962,-0.010235591,-0.058750395,-0.027170077,-0.05429227,-0.105675794,0.063659646,0.123696946,-2.350208e-33,0.07905159,-0.106841475,0.060982373,-0.03509954,-0.037988402,0.024584463,0.026600342,-0.066379525,-0.007951539,0.012454934,0.01006163,0.017654723,-0.02997364,-0.00636017,0.08232816,-0.053181328,0.022097113,0.09081936,-0.026753074,-0.081074424,0.05279402,0.020818764,0.038951863,0.02425321,0.07184401,-0.008733146,0.053582408,-0.0228866,0.0102938665,0.13185786,-0.0017888871,0.036161795,-0.024051735,-0.038159613,0.05499537,0.10278289,0.0077000246,-0.0061361697,-0.08498337,-0.018114557,0.02436005,0.049099285,0.0019776484,0.044776857,0.06379068,0.022982247,-0.049869698,-0.049832676,-0.030869327,-0.07598692,0.0146388225,-0.038850747,0.0017465913,0.015097236,0.035074677,0.09003778,0.010778088,0.049962528,0.02802891,-0.05692747,-0.0842117,0.033417065,-0.047615692,-0.039300784,0.05661712,-0.084548995,0.013379925,0.081868716,0.035453755,-0.006714714,-0.028933141,-0.048802916,0.08241961,0.11365163,-0.048193622,-0.0748732,-0.051300786,-0.06184736,0.038321145,-0.055714976,-0.035716265,0.028113097,-0.005000705,-0.026288103,-0.015534183,-0.05067008,0.06703722,0.12196384,-0.035456534,0.02960872,-0.0047441167,0.032167695,-0.09045672,0.006095918,0.00027873213,-4.0696033e-08,0.08448484,0.004376689,-0.012797457,-0.08891614,-0.02733207,-0.015332847,-0.028385019,0.07689429,0.0138516575,-0.045876376,-0.019749118,0.14620395,0.03903978,0.049315304,-0.032778677,0.048378628,-0.035544764,0.007052656,-0.025419706,-0.015540974,-0.09639212,-0.002962934,0.02230136,-0.027844852,-0.04151494,-0.12406778,0.008530044,0.10517066,-0.055849157,0.029814245,0.0038330862,-0.002446351,-0.04029781,-0.11921087,-0.0068088165,0.065435894,0.026805371,-0.07231611,0.049994383,-0.008182164,0.0046728905,-0.019042358,-0.00647001,0.01238439,0.024337834,-0.0054948335,-0.024142735,-0.0035099082,-0.04199826,0.03410047,-0.02257504,-0.033640865,-0.057548523,-0.1066709,-0.087969445,-0.08520755,-0.04996974,-0.084559515,0.06175344,-0.05180624,-0.020475008,0.06912235,0.099047616,-0.03902818 +2.7.1.236,"The enzyme, best characterized from the plant pathogenic bacterium Xanthomonas oryzae pv. oryzicola, is considered a bacterial type III effector. The product, 3'-NADP, is believed to enhance bacterial virulence on plants through manipulation of primary metabolic pathways. In vitro the enzyme is also active with nicotinate adenine dinucleotide (deamido-NAD).",384,0.99999994,-0.076354444,0.00943967,-0.05005318,-0.07842241,0.040049344,0.06498031,-0.057410732,0.04848322,-0.0014566837,0.023010638,0.0871014,-0.029425334,-0.025940418,0.07513296,-0.015955297,0.08635159,-0.032292508,0.049016904,-0.00894068,0.038551986,0.109812334,0.0988101,0.010336859,-0.019176025,0.013905295,0.008645778,-0.035326183,0.050761346,0.013485921,-0.05919144,-0.08415684,0.050592873,-0.025145423,-0.089287475,0.053559244,0.015651446,6.6660723e-06,-0.03855288,0.011286759,0.028978879,0.04323982,-0.0054465947,-0.061622553,-0.01282243,-0.067827,-0.05524184,-0.014231984,0.049831383,0.03645961,-0.07185509,-0.046337258,0.0015266525,0.027170401,-0.015285603,-0.00051816064,-0.08101126,0.020746216,-0.012630418,-0.08620598,-0.017984528,0.04016226,0.011803835,0.020435207,0.035108414,-0.00022498894,-0.017176505,-0.03963918,-0.06885594,-0.023937171,-0.03588026,-0.06525115,-0.0858694,-0.019558752,0.0574311,0.0004714699,0.02745027,0.01519557,0.01603423,0.032218322,-0.046413362,0.047923923,0.03197215,-0.0052514956,0.13647383,0.02060795,-0.041015398,-0.002021279,0.08792828,0.025212733,0.026445914,0.02295455,0.0133581,-0.0041982764,-0.015939724,-0.1218514,0.023393426,0.033418354,-0.09852451,0.019857705,0.0024506366,0.012571326,0.03158563,-0.06592908,-0.08980046,-0.04021701,0.028330216,-0.011857766,0.010748287,-0.031840224,0.028799279,-0.040343493,-0.029878328,-0.055457707,-0.013730448,-0.077818714,0.08845202,0.053931255,-0.01478783,-0.07757368,-0.069106154,0.03329768,-0.13756683,-0.022669239,0.1117543,-0.046683688,0.019155094,-0.08740259,3.0533675e-33,0.032142352,0.052158497,-0.022147736,-0.06957147,0.06441412,0.03359547,0.022602884,0.02919177,-0.04282646,-0.06302084,-0.036778633,-0.13101579,0.010745721,0.045211658,-0.0016041743,-0.01958548,-0.09075778,0.00909902,-0.03838349,0.027987408,0.06813708,0.036317877,-0.06079841,0.044785827,0.025951108,0.054233164,0.015943743,0.007494683,0.008836248,-0.050715905,0.12475501,-0.11929315,-0.12268848,-0.04222081,0.020376327,0.007106602,-0.021782218,-0.07596919,-0.0149178095,0.07937876,-0.06463845,0.09710504,0.06308658,-0.04541379,0.07808244,-0.011375939,-0.07072702,0.10471186,-0.005675538,0.041512955,0.052089505,-0.020591134,0.04441798,0.016592018,0.011521357,0.024390392,-0.030696137,0.06131413,-0.02845074,-0.020891367,0.0063856137,-0.027808085,-0.009429754,-0.002986942,-0.07218027,0.016532276,-0.035900854,-0.093447536,0.07199861,0.06626254,-0.048551697,-0.03342729,-0.0041194176,0.041581195,-0.020817839,-0.0468004,-0.07762452,0.033472426,0.05627125,0.020853464,-0.024239343,-0.04359806,0.03383069,-0.038625974,-0.104024455,-0.03243695,-0.0038916748,0.04817395,-0.026394635,-0.0004670626,0.14984769,0.020678792,0.032401487,0.020302212,-0.01869201,-3.9854434e-33,0.043996163,-0.020271685,0.10573156,-0.046378158,-0.0060732947,0.04297306,-0.056042552,0.006215406,0.014273998,-0.024695871,0.040290296,0.055271525,0.08497331,-0.025572378,0.066621274,0.050570685,0.057139896,0.07695171,-0.062315706,-0.016039422,-0.04011753,0.07277523,0.017884355,-0.038804688,-0.0065066745,-0.0010393126,-0.0059972852,0.010770904,-0.031502746,0.04561694,0.006452048,0.0469784,-0.06560913,0.0029245673,0.080144055,0.014579336,-0.004511973,-0.0492063,-0.020755127,0.061644733,-0.012294482,0.07422763,-0.01566004,0.06695528,-0.023541043,0.03973756,-0.08195701,0.003458697,0.051676866,0.03844102,-0.017331969,5.399256e-05,-0.0045129494,0.025495209,0.02423074,0.008256357,0.008444494,-0.021587431,-0.05321092,0.013919142,0.016975317,-0.07712894,-0.0007496662,0.012507461,0.0017755809,0.0628834,-0.017051594,0.022526925,0.036468383,-0.049325917,0.012687074,0.020175677,-0.016912503,0.031714287,-0.10071925,-0.014812128,-0.0294492,-0.07063543,-0.042192142,-0.0060376935,0.0015294374,0.005235879,-0.033705015,-0.051971372,-0.018248552,-0.02425637,0.03576074,0.13785155,-0.011082667,0.0043425797,0.013802637,0.00071652344,-0.017747637,0.07334769,0.12225043,-3.6299888e-08,0.03524629,-0.08339851,0.046559907,-0.033614628,-0.047763392,-0.021909611,-0.008597269,-0.02093517,0.07263511,-0.0038653947,0.009741116,0.09410961,-0.0041191815,0.03355057,0.10315585,-0.06035594,0.086572826,0.047029406,-0.061431795,-0.021454673,-0.05086919,-0.02421586,-0.100514434,0.0063075745,0.013059507,-0.029945927,0.016510732,0.015524326,0.09940447,-0.04345937,-0.042601917,0.035766594,0.02585368,-0.019593088,-0.07349985,0.084741786,-0.039033853,-0.051977813,0.023459315,0.014129831,0.024010194,-0.080097616,-0.038039092,-0.008862776,0.057628382,0.003390145,0.04977673,-0.045338262,-0.057041645,-0.028902018,0.028112102,-0.033502817,0.0677713,-0.10447978,-0.093384534,0.054639004,-0.043901257,0.015851445,0.0047525773,-0.05387505,-0.007569802,0.00455641,0.17223454,-0.029763278 +2.8.3.27,"The enzyme is most specific in Escherichia coli, where the preferred substrates are propanoyl-CoA and succinate. In other organisms, the enzyme uses acetyl-CoA at the same rate as propanoyl-CoA (cf. EC 2.8.3.18, succinyl-CoA:acetate CoA-transferase).",384,1.0,-0.06907632,-0.10514061,-0.10066504,-0.009578213,0.090393625,0.07232917,-0.1275289,0.04094531,0.024359535,-0.038413014,0.03704764,-0.07178765,-0.10176392,0.102486126,-0.02166464,-0.011454754,0.05096153,-0.01880689,0.046184946,-0.059019208,0.075295694,-0.036536653,-0.04436054,-0.008498801,0.054528408,-0.03096272,0.01705476,-0.007463146,-0.010508132,-0.070207044,-0.056296825,-0.06159285,0.054884885,-0.023457354,0.052001532,0.032444846,-0.055132028,-0.08320037,0.0983915,0.027871484,0.03589257,-0.0478855,-0.023201533,0.0075141266,-0.019134236,-0.0686652,0.010490456,-0.001333363,0.036396578,-0.020968981,-0.03318524,-0.014538149,-0.03802063,0.055833258,-0.02857076,0.004280725,0.015183546,-0.083961315,0.01756705,0.030136291,-0.00871437,0.03231299,-0.043659132,-0.019351391,-0.005149762,-0.066715226,0.041933537,-0.008093773,-0.0005654983,-0.00045117893,-0.047001325,-0.036557477,0.014473983,0.10852914,0.049492337,-0.043383658,0.020875055,-0.056375563,0.03815779,0.010781134,0.0069711837,0.00045518318,-0.050326444,0.039370257,0.05314553,0.04741539,0.013639966,0.019154735,0.013622938,0.01750098,0.045361355,-0.018404245,0.026117472,-0.111355506,-0.02503207,0.044657234,-0.017147612,0.013472256,0.07108617,-0.05697299,0.003297178,0.06292663,-0.00017779587,-0.017762225,-0.022369161,-0.004456153,0.017948046,0.10161583,0.02417045,0.04607878,-0.0051265038,-0.018866722,0.030699695,-0.028662156,-0.005612054,0.031015033,-0.02856168,-0.081464246,-0.0362576,0.074343115,-0.023518551,-0.021256197,0.07055038,0.10945416,0.027977647,0.082876734,-0.058985,2.6010632e-34,0.06634018,0.004403924,0.041585658,-0.048558615,-0.0067527806,-0.048732564,-0.060239196,0.0435593,-0.031169953,-0.02341295,-0.009371359,-0.033709787,0.01947443,0.06135528,0.025297567,-0.002925056,-0.009388833,-0.022048479,0.038997184,0.06787319,-0.022197524,0.027793556,0.007280922,0.05031495,0.01838883,-0.04429761,-0.068247914,0.12065333,0.021351177,0.014737008,0.017363986,-0.05484786,-0.034226876,0.01635278,0.06778076,-0.05308781,-0.054173183,-0.02818238,-0.013991391,0.08497337,0.07497045,0.09144637,0.037653882,0.039407637,0.025877671,-0.034335855,-0.026052745,0.07593652,0.0014024818,0.029920436,0.054377742,-0.01761027,0.05892658,-0.094184026,0.045705784,0.062384136,-0.017344896,0.030543258,0.061264228,0.015019191,-0.042423654,0.054027256,-0.027620096,0.052413747,0.0037705628,0.07705625,-0.076949835,-0.07239872,0.0078692,0.0650261,-0.07148121,0.0036128566,-0.027071472,0.04626358,0.050706975,-0.06282622,-0.044520017,0.034980085,0.058774922,-0.036103364,-0.028012896,0.0065217754,-0.039428126,0.008783791,-0.06612194,-0.015097032,-0.036976367,-0.04571981,0.020181507,0.059532307,0.06573678,-0.05871227,0.01109044,0.022124471,0.025498195,-1.857077e-33,0.10381752,-0.1351495,0.031683557,-0.09302517,-0.14442118,0.084868245,0.02192282,-0.07687591,0.04153677,0.030695029,0.07808332,0.03036664,0.031235086,-0.037024118,-0.010174272,0.022151778,-0.036873605,-0.015792968,0.006093506,-0.015472828,0.014153039,0.046602033,0.09275641,0.007876851,0.08893576,-0.04775986,-0.08582238,0.07933986,-0.0052411295,-0.007953316,-0.065881796,-0.019696016,0.014426954,-0.04353727,-0.09955976,0.038151715,-0.0140065765,0.059977546,0.0066327085,0.017164763,-0.04262011,0.06126089,-0.013128198,0.07879382,-0.045890793,0.025817221,-0.049304195,-0.052778963,0.03223571,-0.075885035,-0.03400426,-0.062475294,-0.056556396,-0.057375032,-0.019184547,0.061647292,-0.034585718,0.021317888,-0.008426067,-0.06940833,0.008119787,-0.030899785,-0.01974719,-0.030682353,0.0647323,0.0568652,-0.034861483,0.030456068,0.012024507,-0.045691658,0.04611908,0.03217116,0.07104062,0.05637858,-0.034819745,-0.046781227,-0.025972545,-0.035917845,-0.031173242,0.04995947,-0.031140538,0.023516102,-0.12875967,-0.022262119,-0.10680805,-0.010343965,0.059586536,0.018849285,0.00864533,0.040567867,-0.067252874,0.015824493,-0.035774004,0.030691987,0.027382502,-3.620661e-08,0.04108107,-0.038921624,0.094159625,-0.055361345,0.012126344,0.037295014,-0.009488487,-0.06446869,0.07550784,0.03848325,-0.08605207,0.16694379,0.034022234,0.011530644,0.048836816,-0.023929168,-0.0015576879,-0.009652728,-0.008912579,-0.013442424,-0.021075742,0.00083270547,-0.049203422,0.02266786,0.021068055,-0.076160625,0.03966813,0.05459155,-0.06382298,0.001087825,-0.053164553,-0.02044638,-0.01222919,-0.03659439,-0.0064815395,0.028493237,-0.03010395,-0.06330301,-0.052223798,0.10821626,0.08129732,-0.026790382,-0.10138167,-0.0006627656,0.023356551,0.04558569,0.017673256,0.039693728,0.005237003,-0.0133412955,-0.00045093714,-0.07698045,-0.059882354,-0.02467049,-0.017423222,-0.013559558,-0.0007482973,-0.10024192,-0.040257394,-0.020166563,0.05206469,0.07222167,0.20751847,-0.02060856 +2.8.3.28,"The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminophenyl)succinate. It has a broad substrate specificity towards other C4-dicarboxylic acids, phenylacetate, and the non-physiological compound 2-naphthylacetate. The enzyme produces 2- and 3-phenylsuccinyl-CoA in equimolar amounts. It can also perform an intramolecular transfer of the CoA moiety to convert 2-phenylsuccinyl-CoA to 3-phenylsuccinyl-CoA.",384,1.0,-0.023990208,-0.09087268,-0.08632632,-0.02622961,0.07885908,0.0836924,-0.08909121,0.007918642,0.06233863,-0.035482354,0.017575826,-0.08658348,-0.016035313,0.02819081,-0.07229919,0.028046785,-0.040503915,0.0208302,0.0027501918,-0.06413406,0.021939266,0.006881279,-0.019054169,-0.016485,0.07083931,-0.0052277595,0.016024323,-0.04642734,-0.06166358,-0.08518295,0.091498286,-0.06496561,-0.0027123482,-0.025143296,0.048408337,0.042845443,-0.05375654,-0.06394268,0.11848515,-0.0017572017,0.02128591,-0.04097905,-0.07319914,-0.0360086,-0.05735203,-0.017823799,-0.040257085,-0.0027879574,0.10246948,-0.05103244,-0.0540251,-0.030183611,-0.062031988,0.05847586,-0.013219961,0.027496867,0.005667159,0.013301171,-0.060237754,0.051576614,0.015417948,0.00793649,0.0031277032,0.01748081,-0.0035765325,-0.05118481,-0.004208785,-0.0415721,0.02439793,0.01256768,-0.09450795,-0.06459823,-0.018789068,0.056536615,0.053384107,0.030391518,-0.054912154,-0.023281,-0.000933407,-0.052560963,0.021657638,0.042162083,-0.0229959,0.07526172,0.025779493,-0.007298958,0.04609224,-0.07207615,0.060864177,0.039213844,0.02793407,0.036869116,-0.011860138,-0.047043644,-0.08345858,0.047819506,-0.004952843,0.03000786,0.046934485,-0.016309733,-0.033695128,0.088780575,-0.026416503,-0.1466413,-0.12559433,-0.035961855,-0.010893576,0.07184785,0.03661816,0.021979824,0.0033473815,-0.019361101,-0.021716708,-0.057021916,-0.017434308,0.07758551,0.039359517,-0.030936887,-0.06506994,-0.019834679,-0.03342099,-0.009339184,0.1315534,0.04914825,-0.0055738194,0.03190277,-0.056790087,2.0939415e-33,0.060644258,-0.013190041,0.02749491,0.072174035,-0.0150054945,-0.030058045,-0.09489463,0.04866396,-0.013916234,-0.037473943,-0.017136049,-0.0457428,-0.0023058075,0.0016414463,0.045947257,-0.055500545,-0.014964947,0.016271558,0.06592688,0.025705142,-0.026201319,0.04465429,-0.0057140705,0.07665219,0.031608775,0.0077115423,0.005486002,0.1314266,0.041323986,0.0023252668,0.058297444,-0.06471871,-0.13666707,-0.027975908,0.023980737,-0.0832745,-0.05493414,-0.008387849,0.017376143,0.10303389,0.030514846,0.040678214,0.06682702,0.034394104,0.0075361603,-0.0068692616,0.016778724,0.108490095,0.00097541464,0.0082764495,0.001135448,-0.043317888,0.16439079,-0.011484746,-0.02774792,0.072947435,0.0007175955,-0.04233079,0.059120715,-0.02403565,-0.019591734,0.06296184,-0.0038222733,0.02778145,-0.0017702635,0.031606033,-0.1150646,-0.039223548,0.03756527,0.07332739,-0.021316873,-0.011249766,-0.019903205,0.05526675,0.08483522,-0.0439654,-0.043259062,0.0062958095,0.06257594,0.013132696,-0.029446129,-0.008237872,0.03203287,-0.011628809,0.022276858,-0.025645182,-0.05095019,-0.052885406,-0.02052474,0.09007765,0.032966238,-0.07424627,-0.033924356,0.01015115,0.0049534966,-3.793734e-33,0.118676394,-0.13133575,0.024865719,-0.0691223,-0.07605069,0.04564662,-0.008649624,0.078174695,-0.043060392,0.022369027,0.084927365,0.02646135,0.055350482,0.014582138,-0.0013718269,-0.012118987,0.02792201,0.013379221,-0.036156073,0.037435174,0.009162417,0.07453877,0.032065604,-0.05574065,0.04967994,0.0371041,-0.0009773057,0.03719266,-0.02829179,0.058502685,0.03685642,-0.02829075,-0.010917648,0.02049754,-0.041902572,0.034564655,3.4010187e-05,-0.03552548,-0.04797681,0.033680942,-0.06274472,0.024087282,-0.0051308293,-0.030140866,0.058334026,-0.040739223,-0.086742625,0.025607998,-0.0168408,-0.048983417,0.0025792667,-0.020755796,-0.021265866,-0.016351378,-0.03223299,-0.0038605826,-0.010815605,-0.047203407,0.015900508,-0.05629281,-0.04301454,-0.090806976,0.049646407,-0.015273894,0.061943162,0.05537178,-0.029683037,0.08435965,0.054828554,-0.08051289,0.0703869,-0.0484954,0.07339903,0.045267474,-0.03621578,-0.048927817,-0.027803162,0.033004712,-0.0060717394,0.008396457,-0.041234046,-0.05896422,-0.044431027,-0.12602824,-0.05642962,-0.086039394,0.046066087,0.015437609,-0.03537097,0.046230547,-0.047885343,0.05720586,-0.0068716225,0.08369842,0.072930306,-4.562259e-08,0.013642765,-0.050077762,0.07885865,-0.0029394543,0.056874607,-0.019676793,-0.08437981,-0.097906984,0.04549053,-0.024966266,-0.09101363,0.08515053,0.017302778,0.046217166,0.0047478853,-0.0016005476,-0.03892577,0.02235446,-0.020363893,-0.047914363,-0.07493971,0.008121917,-0.0860249,0.07891192,0.08686473,-0.07752492,0.050509285,-0.010696075,-0.02555878,-0.049857307,0.015846558,0.037517663,0.030114057,0.012691873,-0.020986294,0.011466493,-0.05963748,-0.030475212,-0.038652856,0.09386668,0.023063265,0.025233122,-0.09299894,0.020431148,0.014039041,0.0104482155,0.03245512,0.07026705,-0.05498809,0.013616735,0.022971867,0.021050137,-0.038665656,0.025475038,-0.06863568,-0.04033374,-0.00142615,-0.03050967,-0.013196437,-0.032209348,0.017760139,0.030137341,0.16934158,0.00909212 +3.2.1.216,"The enzyme, characterized from the bacteria Flavobacterium johnsoniae and Mucilaginibacter mallensis, uses anomer-inverting mechanism to release beta-glucose from the non-reducing ends of kojibiose and alpha-1,2-oligoglucans with a higher degree of polymerization.",384,1.0,-0.115461044,0.0002598771,-0.12610741,0.0767009,0.034471896,0.0329552,0.0069436296,0.01635194,0.043744422,0.020684402,-0.020547362,0.037324905,-0.10575678,0.048720013,-0.09482949,0.059118494,-0.06208214,0.08222279,0.03644203,-0.023427246,0.035535358,-0.039640736,0.07665034,-0.013194399,0.03802167,-0.034793526,0.026713436,-0.0693149,-0.011415085,-0.02396264,0.09469104,-0.021987805,0.07274799,-0.019837352,-0.013186442,0.10358878,-0.030660382,-0.08768875,0.062096536,-0.011147568,0.12533829,0.024988696,0.019275254,0.020024633,-0.004855569,-0.002282471,-0.057301473,0.072907455,0.06740353,-0.04114293,-0.103791125,-0.037749346,-0.06973675,-0.030757912,0.030255178,0.08925185,-0.046210974,-0.03203682,0.0005227941,0.009386863,0.03253842,0.024604045,0.011983384,0.066447474,-0.093693435,-0.0786887,0.025243748,-0.014986035,-0.0035709732,0.021470392,-0.059559125,0.002227918,-0.03842955,-0.021238506,0.038812205,-0.017637255,-0.042697124,0.035865504,-0.036992893,0.05181428,0.03753992,-0.09724395,0.09129077,0.03655434,-0.030127788,-0.035443906,0.07229964,0.027380424,0.062668905,0.05638032,-0.0103069935,0.06597765,0.025787681,-0.03714991,-0.061288774,-0.0638379,0.037722297,0.011329418,0.015450634,0.025059868,-0.016877398,0.017041009,0.09154043,-0.087911405,-0.08307,-0.034458667,0.003478653,0.05379963,0.057076287,0.03184642,0.035266098,0.013459668,0.065426074,-0.037777904,-0.06494167,0.022581233,-0.026762951,-0.009072937,-0.018514276,0.0733798,-0.008606195,-0.0750907,-0.012671183,-0.019392494,-0.09574816,0.092500344,-0.079398066,1.9159978e-33,0.057818875,-0.01101098,-0.008493253,-0.04023965,-0.0112422,-0.024891818,-0.070330605,-0.041622773,-0.051162142,-0.01556057,-0.0493824,-0.025813328,0.0058217095,0.08873676,0.058025233,-0.02145556,0.012927231,0.02768414,0.08644622,0.038386952,-0.0052945237,0.055074017,-0.0122984,0.009334578,0.101976186,0.015129302,-0.01680218,0.009514921,0.019650353,-0.0018079949,0.08789874,-0.06614667,-0.1088466,0.04873547,0.024688156,0.01620024,-0.040382326,-0.05632767,-0.002515524,0.017100884,-0.01591939,0.007919342,0.015886283,0.009566182,0.060463265,0.005129758,0.028572677,0.02284833,0.028212683,0.115480736,-0.013866982,-0.034796413,0.04382674,0.056862276,-0.013121006,0.07511732,0.023511019,-0.015447057,0.010475617,-0.034932353,-0.06767391,0.024098985,-0.0060519734,-0.037390377,0.015969312,-0.015530579,-0.01219598,-0.049077246,-0.07287612,-0.02171262,-0.05234053,-0.010124138,0.0035328236,-0.009975024,-0.015069233,-0.010521022,-0.07611754,-0.08723335,0.025135618,-0.0666921,0.021453995,0.013989857,0.024202982,-0.034783438,-0.062991366,0.021406278,-0.048988953,0.049006037,0.026400423,-0.024951395,0.015162632,-0.06587071,-0.10676397,0.040483657,0.05215233,-2.829535e-33,0.083360195,-0.08138154,0.024480378,0.008423472,-0.08233518,0.019818062,0.045711156,-0.07408132,-0.0016515598,-0.023905147,0.02846154,0.020966383,0.02637427,-0.017692976,0.008432831,-0.023511576,0.047397714,0.105108835,-0.11138136,-0.0725417,-0.0057973447,0.06809907,0.061968047,-0.013637123,-0.015687605,0.008787986,0.0321584,0.07991442,0.005372014,0.057305273,-0.034799255,-0.013431844,0.013939873,-0.10345592,-0.027037866,0.036227427,-0.0127530275,0.009141209,0.02249045,0.014964419,0.07835333,0.052957855,-0.024646824,0.049272057,0.031061294,0.045859724,-0.062267844,0.01878808,0.018336816,-0.07497022,-0.07289536,0.015524151,-0.011670467,-0.02638492,0.003439827,-0.015826657,0.013914137,0.011039995,-0.03224756,-0.05228274,-0.00277363,-0.0826172,0.115110904,0.0229893,0.035856765,0.10562654,0.08317031,0.08220709,0.02935868,-0.06683796,0.0022071935,-0.019097483,0.011600561,0.09502638,-0.006783115,0.026268816,-0.12879667,-0.0583764,-0.033353817,-0.04641548,0.024144987,-0.06012785,0.0020943973,-0.08067426,0.014252101,-0.10929307,0.06370926,0.005607312,0.01786553,0.027343707,0.050895218,0.051929712,0.019825017,0.02439106,0.015181508,-3.4848288e-08,-0.018071322,-0.08965414,0.062080786,-0.01907081,-0.024768084,0.054573424,0.019842504,-0.0009857976,0.030462664,-0.085741416,-0.029494394,0.13124163,-0.038831435,0.09865667,0.08479992,0.00797937,-0.059686832,-0.009128141,-0.031950217,0.029166164,-0.10869806,0.012226588,-0.045945063,0.0287777,0.0064335167,-0.084570356,0.005921482,0.052871805,0.02187603,0.00092338683,-0.008587268,0.08668973,0.023098713,0.046682328,-0.13867334,0.00766879,0.023123603,-0.0035738905,-0.026366988,0.028447779,0.0014470839,-0.026024014,-0.0610726,0.006713733,-0.052124213,0.037803076,0.023321316,0.047611848,-0.051493626,-0.019253818,0.04173045,-0.022974327,-0.069695406,-0.044530947,-0.105594784,-0.04767654,-0.047561076,0.028940516,0.0030879912,-0.04153199,-0.063544914,-0.025869176,0.11254649,-0.03483824 +4.2.1.180,"The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway in which it catalyses the hydration of (E)-benzylidenesuccinyl-CoA.",384,1.0,-0.120528296,0.016359651,-0.07698605,0.010883377,0.101315305,0.067100264,-0.041058566,0.02300459,0.09696286,-0.028053055,-0.045101263,-0.09849833,-0.040927626,0.057759058,-0.12735109,0.032933973,-0.048693154,-0.00630419,-0.03147016,-0.0770951,0.029893499,0.0013178908,-0.0028690265,0.03574906,0.018599901,-0.036843017,0.059998665,-0.07965433,-0.06794252,-0.022259466,0.036529824,-0.0042074136,0.023249837,-0.07417022,0.04669539,0.17136405,0.022164635,-0.10909206,0.048960894,0.012176401,-0.0026568156,-0.0261723,-0.04886893,-0.028238118,0.012351759,-0.01632588,0.0026144022,0.051649153,0.008264983,-0.052361764,0.0046112095,-0.0015736052,-0.060518555,-0.038409136,-0.039880615,0.040090412,-0.007902628,-0.03500748,-0.13091315,0.031449117,0.060131427,-0.011968414,-0.020041794,0.05001701,0.009357239,-0.09965131,0.07340668,-0.024181288,0.038776655,-0.023027038,-0.13798769,-0.081033915,-0.03188828,0.008465119,0.028990706,-0.027933221,-0.018881425,0.021565942,0.039386235,-0.08081892,0.04308281,-0.013518917,0.006179684,0.049153145,0.047603626,0.009553443,-0.002123084,-0.03553328,0.14044523,0.049323633,0.02705652,0.051232453,0.006125629,-0.029100731,-0.098495886,0.04415335,0.070635766,0.022682896,0.03115594,-0.0013961253,0.018774977,0.06415395,-0.034327146,-0.08240084,-0.008321708,-0.018445851,0.034531493,0.11259369,0.08505928,-0.027904738,-0.013099729,-0.0025615029,0.0837135,0.014994282,0.0048370683,0.050145175,0.001150066,-0.044839058,-0.0679504,0.06378809,-0.055085707,-0.024394818,0.007838368,0.033974625,0.0074987407,-0.0010889561,-0.07198734,8.363409e-34,0.1113683,0.012472698,0.019271564,0.04390013,-0.05078364,-0.0035104912,-0.046577446,0.038359024,-0.04967699,-0.050603338,-0.022124719,-0.086377494,-0.023018846,-0.030001765,-0.022738658,-0.014547884,-0.016344855,0.017864607,0.00599928,-0.014001358,-0.02543261,0.041609332,-0.0048656967,-0.022818927,0.0723692,0.05682303,0.01726196,0.03295888,-0.007692719,0.0028531698,-0.0034053857,-0.0732942,-0.10894409,-0.0039390232,0.0022092503,-0.0044826725,-0.028082844,0.031352587,-0.011712745,0.09685215,0.035826255,0.04826119,0.0023645856,-0.04896627,-0.027500356,0.02731887,-0.013700476,0.08863763,0.028840043,0.00075812626,0.037295453,-0.025016725,0.09303478,-0.02249382,-0.09465673,0.085505955,0.035730626,0.018545981,0.046075076,-0.017838106,0.021205915,0.06094287,-0.057496194,0.053557236,0.013243719,-0.02301954,-0.07487859,0.03535868,0.010292736,0.07454497,-0.10391865,0.013028505,0.053315364,0.06673842,0.041304495,-0.06208292,-0.0973492,-0.012400374,0.03955958,-0.011263493,0.009797613,-0.05890071,0.03457205,0.008041824,-0.03777873,-0.00808835,0.017712824,-0.024349172,0.04166334,0.027736336,0.029074695,-0.09375274,-0.008412342,-0.049507007,0.051283423,-2.2727436e-33,0.14319786,-0.08680875,-0.033899985,-0.07522399,0.026609655,0.009874108,-0.02339129,-0.0010310027,-0.014439294,0.004243606,0.0885328,0.009534603,-0.004427115,-0.050331637,0.03197363,0.003135064,0.08715014,-0.0031729024,-0.033255443,-0.05002686,-0.062381286,-0.03884128,0.0063250973,-0.07831734,-0.017564498,0.03803666,-0.012694155,0.0468858,0.057791106,0.032312155,0.01399517,-0.029583165,-0.029987285,-0.021812247,-0.0380335,0.05937577,-0.041381042,0.03473306,-0.0052072224,0.02449015,0.039021004,-0.053523734,-0.0072890925,0.024205754,0.055705026,0.013539921,-0.1127008,-0.059659045,-0.021625686,-0.062178284,0.08013288,-0.03139737,-0.019766018,0.0066455235,0.018319756,0.060648095,0.02538276,-0.06027372,-0.019130312,-0.024980582,-0.05981204,0.030271022,0.016259061,0.00920335,-0.017758314,0.04005641,-0.079014055,0.11495557,0.038670413,-0.04243433,0.13191119,0.0021292323,0.033791196,0.06572435,-0.033558354,-0.06375822,-0.037591573,-0.038399193,0.02421449,-0.0469974,-0.03903629,-0.02766222,-0.019730447,-0.05004191,-0.021785721,-0.124634586,0.03550921,0.023753636,-0.019205756,-0.0019848512,0.04160384,-0.044622503,-0.051515467,0.10082112,0.052244574,-3.1819006e-08,-0.022693148,-0.08263933,0.01770461,0.009539684,0.0035777641,-0.0019486371,0.04672015,0.05147026,0.074603,-0.05326777,-0.024746003,0.024835542,0.050186805,0.052118782,0.046693143,0.03892903,-0.048605334,-0.007422234,-0.04185793,-0.023006655,-0.06571266,-0.0041784924,-0.06379207,-0.00044653518,0.045358468,-0.010893844,0.0359917,0.04362448,0.0059941225,-0.028382974,-0.042086806,0.056216612,-0.007729081,0.080691405,-0.0014296416,-0.013625538,-0.016734727,-0.053224757,-0.03860524,0.055414487,0.027896894,0.037233725,-0.09548928,0.016122771,0.12782358,0.029894687,-0.02331408,0.05121244,0.015637547,0.012183629,-0.002484253,0.009050002,-0.053707615,0.02063502,-0.07425676,-0.010462156,0.024559515,-0.024313906,-0.026340095,-0.074942335,0.05265785,-0.017112516,0.2016847,-0.063368544 +6.2.1.75,"The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate. It is also active with phenylacetate and the non-physiological compound (2-naphthyl)acetate.",384,0.99999994,-0.014868017,-0.07327455,-0.069522016,0.0063839154,0.052871805,0.06583821,-0.03192289,-0.026044635,0.07645665,-0.028426252,-0.020856012,-0.021341477,-0.07734559,0.037770536,-0.05480482,0.08335711,-0.05623733,0.007921147,0.0174297,-0.071560055,0.038410347,0.050991368,0.008130328,-0.024559783,0.025471224,0.0012220282,0.04935355,-0.046635546,-0.06603314,-0.0858734,0.042089105,-0.017434966,0.02964407,0.0034079663,0.04556637,0.066368006,-0.036684442,-0.07969242,0.07200836,-0.0034104458,-0.008266367,0.00564518,-0.0902344,-0.077992946,-0.01899492,0.0068154056,-0.03888068,-0.0062573547,0.044264536,-0.048973355,-0.025014905,-0.01172042,-0.022697214,0.008477313,0.021241512,-0.032504328,0.03754919,-0.012870006,-0.11164685,0.037653856,0.05966533,0.021956077,0.0038580415,0.008882951,-0.014799958,-0.08570695,0.07527107,-0.065616325,0.022279806,0.006792488,-0.1088944,-0.1310054,-0.037625834,0.021001318,0.027258104,-0.0039183507,-0.074061915,-0.03270696,0.020448545,-0.08053117,0.04024545,-0.006158437,-0.033124465,0.06865119,0.015638413,0.008777877,0.022206515,-0.06375528,0.08993383,0.018115437,0.014932982,0.011967718,-0.012539425,-0.075729,-0.017638303,-0.0150197605,0.039914936,0.0072973496,0.021443762,0.00245593,-0.009739352,0.067989856,-0.0633252,-0.12721139,-0.12835248,-0.00855781,0.019878132,0.06652882,0.057928734,0.0289601,-0.025570504,-0.0070966613,0.017866356,-0.0020506566,-0.05132147,0.04881288,0.021317141,-0.033668395,-0.045958333,0.0046228063,-0.03081393,-0.04402077,0.07712318,0.09248783,-0.030887302,0.04315226,-0.05737422,-1.6723422e-33,0.036444664,-0.008790721,-0.02892054,0.00017845638,-0.0095930975,-0.012423322,-0.06676558,-0.019967293,0.004042584,-0.09735076,-0.005060021,-0.050972838,0.015550898,-0.027303062,0.05017195,0.008130597,-0.056084115,0.047899693,0.06590274,0.009229602,-0.028208598,0.046217136,-0.035250988,0.058672316,-0.0039221803,0.038679462,0.022635836,0.080482244,-0.05213649,-0.022899963,0.042421717,-0.065221585,-0.115718454,-0.015748333,0.046127528,-0.015246156,0.009551287,0.010637575,-0.0018527259,0.047775168,0.044350274,0.05063184,0.087496184,0.019957483,-0.022209976,-0.02901592,-0.011414576,0.16364224,0.011742542,0.021731785,-0.036618304,-0.06408138,0.16734691,-0.053583544,-0.051543493,0.09113171,0.017434943,-0.012204856,0.042743053,-0.0029673036,-0.023997314,0.031297337,-0.029294694,0.034915812,-0.015459569,0.033195533,-0.05758299,-0.0339597,0.044045523,0.11393901,-0.04560089,0.013840803,0.042224757,0.053763658,0.04914464,-0.06582473,-0.04834471,-0.019514505,0.027769066,0.012912706,-0.04547973,-0.045826856,0.03134495,0.0023029153,-0.004800812,-0.046210486,-0.03812835,0.00097086164,-0.020426992,0.09782912,0.05938954,-0.07356554,-0.07281219,0.078427434,0.023206808,-1.7411986e-33,0.08066934,-0.07259309,0.02658105,-0.0722698,-0.05482098,0.061323,-0.00043614366,0.08623072,-0.058917444,-0.018188022,0.079641335,0.00789798,0.06529546,0.012122973,0.01894272,-0.04372601,0.0030304065,0.011829943,-0.019443661,0.03289472,-0.029993247,0.030693978,-0.000384461,-0.04129675,0.018981455,0.05815291,-0.07277599,0.06549829,-0.002334994,-0.0037658836,0.05779472,-0.014172031,-0.0047133164,0.0066510173,-0.0078665605,0.04589003,0.006974997,-0.04359143,-0.036073864,0.006043778,0.01673257,0.07343539,-0.008601325,0.023946814,0.08472439,0.015151094,-0.08733568,0.043643203,-0.020036135,-0.08544646,0.02714307,-0.0125726145,0.026794886,-0.01345912,-0.014998721,0.04857146,-0.017020453,-0.025883645,-0.054557152,0.005677755,-0.070220046,-0.07235642,0.09289836,0.042823184,-0.0007811139,0.019048125,-0.00696242,0.099319264,0.059086215,-0.045123983,0.08037288,0.028482191,0.0017260261,0.07549481,-0.041432146,-0.083477624,-0.0819266,0.025314797,5.4815413e-05,-0.032480597,-0.0024386302,0.011078223,-0.07735541,-0.12358968,-0.045054436,-0.05208274,-0.019894838,0.09055675,-0.0061275554,0.021045605,0.0061505744,-0.0026239976,-0.10434803,0.03295805,0.011380491,-3.7445872e-08,0.016953347,-0.034002457,0.12138654,-0.038927186,0.067023784,-0.01698333,0.022082644,0.022687817,0.10391881,-0.07683011,-0.049180474,0.08385436,-0.032138698,0.01905866,0.022082001,0.0070025465,-0.057885695,0.037209023,-0.020135203,-0.03270183,-0.04390106,-0.011210886,-0.11795519,0.0498268,0.0644749,-0.05709808,0.050298445,0.029542487,-0.02253208,-0.05185044,0.009557063,0.040655088,0.017198982,-0.004365698,-0.08915673,0.009778342,-0.021523468,-0.038851213,-0.040111132,0.08895336,-0.022606809,0.04313102,-0.14650731,-0.020730402,0.06120419,0.03212289,0.019185862,-0.0018858218,-0.03530832,-0.044547077,0.022363922,0.0034492381,-0.028597945,-0.01569951,-0.12356335,-0.0354139,0.0034108362,-0.029687416,0.008477045,-0.050567675,0.074353136,0.0076233605,0.1765465,0.042393856 +3.2.1.217,"The enzyme, which belongs to the glycosylhydrolase 31 (GH31) family, is an exo-acting alpha-N-acetylgalactosaminidase that acts on the innermost alpha-GalNAc residues at the core of O-glycans when no other saccharides are attached to it. Unlike EC 3.2.1.49, alpha-N-acetylgalactosaminidase, it is not able to act on blood group A antigen.",384,0.99999994,-0.01518449,-0.09691445,-0.12607233,-0.055116702,0.008908751,-0.0668196,-0.022173308,0.01109304,-0.041090045,0.037941545,0.042246703,0.062733494,-0.11727488,0.031204881,-0.08443292,0.015867151,-0.006758652,-0.08282995,0.030673422,-0.028654192,0.049500164,-0.026223766,0.018131753,-0.0061493674,0.03059254,0.010009024,-0.0057391734,-0.03137992,0.016842017,-0.10512508,-0.026885964,-0.11959289,0.06855542,0.014562329,0.05970795,0.03361287,-0.03858054,-0.03045033,-0.051003966,0.039802834,0.021482185,-0.069339074,-0.01724885,-0.040033475,-0.04454603,-0.0660711,-0.047657907,0.013831284,0.0064683584,0.084069096,0.016465267,-0.11774656,-0.08473759,0.045277763,0.0476404,0.000527254,-0.07689441,0.0006684435,0.02580797,0.065381214,0.07915253,0.023187015,-0.022669926,0.025009083,-0.022816416,-0.093728654,0.16182345,-0.07446595,-0.07272886,-0.0062122215,0.013094192,-0.042643856,-0.018727887,0.01578144,0.024332155,0.02394621,-0.040835705,-0.0124552855,0.06781492,0.021966549,0.045178913,0.016630357,0.01948956,0.097440824,-0.029571226,0.015615089,-0.018240856,0.016318124,0.06064229,-0.0069300686,-0.02117484,-0.05454875,-0.009995239,-0.03923397,-0.011191184,0.018995076,0.06294971,0.016573323,0.0009906631,0.00066719914,-0.053898577,0.052210722,0.035253327,-0.057533056,-0.11797201,0.08002504,-0.031801444,0.041121356,0.015514696,0.049464334,-0.02468257,0.0038217013,0.04068371,-0.056546327,-0.068303265,0.019870955,-0.00049868034,-0.069321916,0.00669627,-0.010537401,0.018643579,0.004648657,0.0679853,0.06577825,0.030585872,0.11394815,-0.05343286,4.364949e-34,0.12218683,0.020023141,0.005256462,-0.046063665,0.032959916,0.0063761477,-0.017922862,0.015065061,-0.053087182,0.00016652852,0.028701985,-0.052308716,0.06378518,-0.002153175,0.017341053,0.09338904,-0.01758288,-0.05325043,-0.03229289,0.037208717,0.027636921,0.04368077,-0.05837542,-0.014562808,0.0012981367,0.044113453,-0.059529796,0.057739247,0.05264664,0.025412872,-1.9781795e-05,-0.065581135,-0.09577223,0.023974834,0.06696846,-0.02473239,0.0014283874,-0.053313013,0.052534103,0.006617999,0.004885671,0.03623271,0.044106647,-0.021545457,0.023705246,-0.019685876,0.007229,0.030897677,0.022423698,0.07529288,0.061812814,-0.033706695,0.017706856,0.021820148,-0.060682245,0.10558001,-0.041683953,0.0034819392,-0.013997552,0.04146527,0.044545356,0.036225926,0.0365482,-0.0040895734,-0.026462693,0.0025531983,-0.07293774,-0.0019370955,-0.00168083,0.053060625,-0.051663157,-0.062211934,0.041197587,0.011105101,0.015818592,-0.075838596,0.054277107,0.022405323,-0.022590537,-0.056751013,0.012830084,-0.00081542996,0.017520895,-0.021551931,-0.09151794,0.0403794,-0.04952779,-0.080232985,-0.07697408,0.0084729465,0.0072914516,-0.060221013,-0.008070547,0.04504263,-0.03510203,-2.8669756e-33,0.13361304,-0.08943778,0.076481044,-0.05015587,-0.024092058,0.045225672,0.062064793,0.040312886,0.0039196033,0.019988172,0.03514202,0.07412173,0.027379144,-0.0181595,0.08512718,-0.016495004,-0.045359183,0.076237604,-0.013362793,-0.035822883,0.0052288435,0.10943595,0.011390571,0.010466135,0.049518954,-0.02979293,-0.016693508,0.074640445,0.010467439,-0.0010914552,-0.036256015,-0.0016215504,-0.052957155,-0.058633745,-0.061517622,0.019303758,-0.0036774478,-0.05233358,-0.0046677366,-0.016215159,-0.0041415654,0.014700929,0.009639505,0.08121882,0.038094908,0.07785655,-0.039808314,0.062540896,-0.009807606,-0.05261505,-0.008843431,-0.013390473,0.00087375235,0.10593365,0.013915161,0.091119155,0.06392906,0.052572034,-0.051077276,0.01561684,0.0054151095,0.012757541,0.010401905,0.0031775157,0.090110905,0.021343524,-0.022671243,-0.017461285,0.03216612,0.043923307,-0.024795987,-0.044212934,-0.06989692,0.06682369,0.05561842,-0.03836747,-0.10016044,-0.05331834,-0.021583913,-0.046839893,0.014173526,0.0337034,0.01777131,0.048786715,0.06259533,-0.07452504,0.02498497,0.116820686,-0.014527385,0.06469857,-0.057156026,-0.005401201,-0.06700113,0.0550095,0.019577978,-4.2933877e-08,0.06384938,-0.030487912,-0.029079039,-0.092240475,-0.030646572,-0.03627709,-0.052999858,-0.0022430005,0.036999084,-0.019759567,0.0003827968,0.1009404,0.018781468,0.03494533,-0.0054977955,0.018179353,-0.0012268404,-0.023063604,-0.087466955,0.018433737,-0.098900184,-0.021977322,-0.056475863,0.046293017,-0.08468729,-0.06364591,0.02848963,0.1100109,-0.118222006,0.0021849372,-0.053726025,0.05574981,-0.02857098,-0.04394374,-0.076345004,0.022279486,-0.001484724,0.0020067291,-0.013799384,0.003462362,0.05837392,-0.03396732,-0.029386625,0.009172085,-0.025076462,-0.018100575,-0.033614095,-0.080725394,0.004491934,0.06758049,-0.008851698,0.025640022,-0.08791709,-0.036336187,-0.093370125,-0.112125486,-0.044635892,-0.05329553,0.023973648,-0.029137643,0.06866095,-0.013518515,0.19940445,-0.042655773 +3.1.1.119,"The enzyme, which belongs to the glycosylhydrolase 31 (GH31) family, is an exo-acting alpha-N-acetylgalactosaminidase that acts on the innermost alpha-GalNAc residues at the core of O-glycans when no other saccharides are attached to it. Unlike EC 3.2.1.49, alpha-N-acetylgalactosaminidase, it is not able to act on blood group A antigen.",384,0.99999994,-0.01518449,-0.09691445,-0.12607233,-0.055116702,0.008908751,-0.0668196,-0.022173308,0.01109304,-0.041090045,0.037941545,0.042246703,0.062733494,-0.11727488,0.031204881,-0.08443292,0.015867151,-0.006758652,-0.08282995,0.030673422,-0.028654192,0.049500164,-0.026223766,0.018131753,-0.0061493674,0.03059254,0.010009024,-0.0057391734,-0.03137992,0.016842017,-0.10512508,-0.026885964,-0.11959289,0.06855542,0.014562329,0.05970795,0.03361287,-0.03858054,-0.03045033,-0.051003966,0.039802834,0.021482185,-0.069339074,-0.01724885,-0.040033475,-0.04454603,-0.0660711,-0.047657907,0.013831284,0.0064683584,0.084069096,0.016465267,-0.11774656,-0.08473759,0.045277763,0.0476404,0.000527254,-0.07689441,0.0006684435,0.02580797,0.065381214,0.07915253,0.023187015,-0.022669926,0.025009083,-0.022816416,-0.093728654,0.16182345,-0.07446595,-0.07272886,-0.0062122215,0.013094192,-0.042643856,-0.018727887,0.01578144,0.024332155,0.02394621,-0.040835705,-0.0124552855,0.06781492,0.021966549,0.045178913,0.016630357,0.01948956,0.097440824,-0.029571226,0.015615089,-0.018240856,0.016318124,0.06064229,-0.0069300686,-0.02117484,-0.05454875,-0.009995239,-0.03923397,-0.011191184,0.018995076,0.06294971,0.016573323,0.0009906631,0.00066719914,-0.053898577,0.052210722,0.035253327,-0.057533056,-0.11797201,0.08002504,-0.031801444,0.041121356,0.015514696,0.049464334,-0.02468257,0.0038217013,0.04068371,-0.056546327,-0.068303265,0.019870955,-0.00049868034,-0.069321916,0.00669627,-0.010537401,0.018643579,0.004648657,0.0679853,0.06577825,0.030585872,0.11394815,-0.05343286,4.364949e-34,0.12218683,0.020023141,0.005256462,-0.046063665,0.032959916,0.0063761477,-0.017922862,0.015065061,-0.053087182,0.00016652852,0.028701985,-0.052308716,0.06378518,-0.002153175,0.017341053,0.09338904,-0.01758288,-0.05325043,-0.03229289,0.037208717,0.027636921,0.04368077,-0.05837542,-0.014562808,0.0012981367,0.044113453,-0.059529796,0.057739247,0.05264664,0.025412872,-1.9781795e-05,-0.065581135,-0.09577223,0.023974834,0.06696846,-0.02473239,0.0014283874,-0.053313013,0.052534103,0.006617999,0.004885671,0.03623271,0.044106647,-0.021545457,0.023705246,-0.019685876,0.007229,0.030897677,0.022423698,0.07529288,0.061812814,-0.033706695,0.017706856,0.021820148,-0.060682245,0.10558001,-0.041683953,0.0034819392,-0.013997552,0.04146527,0.044545356,0.036225926,0.0365482,-0.0040895734,-0.026462693,0.0025531983,-0.07293774,-0.0019370955,-0.00168083,0.053060625,-0.051663157,-0.062211934,0.041197587,0.011105101,0.015818592,-0.075838596,0.054277107,0.022405323,-0.022590537,-0.056751013,0.012830084,-0.00081542996,0.017520895,-0.021551931,-0.09151794,0.0403794,-0.04952779,-0.080232985,-0.07697408,0.0084729465,0.0072914516,-0.060221013,-0.008070547,0.04504263,-0.03510203,-2.8669756e-33,0.13361304,-0.08943778,0.076481044,-0.05015587,-0.024092058,0.045225672,0.062064793,0.040312886,0.0039196033,0.019988172,0.03514202,0.07412173,0.027379144,-0.0181595,0.08512718,-0.016495004,-0.045359183,0.076237604,-0.013362793,-0.035822883,0.0052288435,0.10943595,0.011390571,0.010466135,0.049518954,-0.02979293,-0.016693508,0.074640445,0.010467439,-0.0010914552,-0.036256015,-0.0016215504,-0.052957155,-0.058633745,-0.061517622,0.019303758,-0.0036774478,-0.05233358,-0.0046677366,-0.016215159,-0.0041415654,0.014700929,0.009639505,0.08121882,0.038094908,0.07785655,-0.039808314,0.062540896,-0.009807606,-0.05261505,-0.008843431,-0.013390473,0.00087375235,0.10593365,0.013915161,0.091119155,0.06392906,0.052572034,-0.051077276,0.01561684,0.0054151095,0.012757541,0.010401905,0.0031775157,0.090110905,0.021343524,-0.022671243,-0.017461285,0.03216612,0.043923307,-0.024795987,-0.044212934,-0.06989692,0.06682369,0.05561842,-0.03836747,-0.10016044,-0.05331834,-0.021583913,-0.046839893,0.014173526,0.0337034,0.01777131,0.048786715,0.06259533,-0.07452504,0.02498497,0.116820686,-0.014527385,0.06469857,-0.057156026,-0.005401201,-0.06700113,0.0550095,0.019577978,-4.2933877e-08,0.06384938,-0.030487912,-0.029079039,-0.092240475,-0.030646572,-0.03627709,-0.052999858,-0.0022430005,0.036999084,-0.019759567,0.0003827968,0.1009404,0.018781468,0.03494533,-0.0054977955,0.018179353,-0.0012268404,-0.023063604,-0.087466955,0.018433737,-0.098900184,-0.021977322,-0.056475863,0.046293017,-0.08468729,-0.06364591,0.02848963,0.1100109,-0.118222006,0.0021849372,-0.053726025,0.05574981,-0.02857098,-0.04394374,-0.076345004,0.022279486,-0.001484724,0.0020067291,-0.013799384,0.003462362,0.05837392,-0.03396732,-0.029386625,0.009172085,-0.025076462,-0.018100575,-0.033614095,-0.080725394,0.004491934,0.06758049,-0.008851698,0.025640022,-0.08791709,-0.036336187,-0.093370125,-0.112125486,-0.044635892,-0.05329553,0.023973648,-0.029137643,0.06866095,-0.013518515,0.19940445,-0.042655773 +1.1.1.430,"Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH (cf. EC 1.1.1.431, D-xylose reductase (NADPH)). Some D-xylose reductases have dual cosubstrate specificity, though they still prefer NADPH to NADH (cf. EC 1.1.1.307, D-xylose reductase [NAD(P)H]). The enzyme from Candida parapsilosis is a rare example of a xylose reductase that significantly prefers NADH, with Km and Vmax values for NADH being 10-fold lower and 10-fold higher, respectively, than for NADPH.",384,0.99999994,-0.019004447,-0.026356012,-0.06848852,-0.045071524,0.008525965,0.04074375,-0.078257516,0.06652336,0.01069307,-0.0006064031,-0.01597279,0.04478989,-0.068442054,0.08522841,-0.024857352,0.012346557,-0.0027117298,0.0010833796,-0.031967964,0.0007023775,0.12011155,-0.026649365,0.043548387,-0.00458027,0.085542336,-0.082412824,0.0066457554,-0.05647844,-0.034788974,-0.08330158,-0.1193379,-0.048805382,-0.025921704,-0.048132464,0.08000474,0.06435878,-0.019764181,-0.019289743,0.055684414,0.0143716065,-0.0024352074,-0.017794237,-0.093854375,-0.0058455113,-0.08472927,-0.0064163324,-0.01888311,0.065921254,-0.010961919,-0.022090975,-0.024133043,-0.017409282,-0.015361972,0.045354687,0.090584084,0.0012645201,-0.01796895,-0.005605511,-0.01413371,-0.05763503,0.026835786,0.0075292434,-0.010973646,0.0031321372,0.008671658,-0.076027796,0.07730603,-0.028459197,-0.027984083,0.003701217,-0.079098076,-0.012516077,0.0109483,0.0037982732,0.03311539,0.031990264,0.074780144,-0.079114124,-0.005699359,0.0011592411,0.06061834,0.06917724,0.016672863,0.027192945,0.07046979,-0.05463099,-0.03750343,0.022252586,0.007875024,0.016910603,0.010134035,-0.021925759,0.026572958,0.04081425,-0.07227652,0.021665907,0.05863537,0.045594458,0.034165066,-0.08258594,-0.02075612,0.046984687,0.06036455,-0.029726334,-0.003706168,-0.008957692,0.00021490162,0.12245017,0.011513001,0.043036528,0.013244461,0.008534831,0.04489043,0.017922014,-0.05484346,0.055406645,0.0064782975,-0.00051589933,-0.10732008,-0.0612536,0.0036301971,-0.007424448,0.035978787,0.0073779197,-0.009062023,0.009789803,-0.07340708,3.0526964e-33,0.080648884,0.066432096,-0.049145184,-0.037588146,0.02131618,-0.032936722,-0.06359742,0.070979126,-0.03174938,0.04414363,-0.022753842,-0.08312214,-0.022271385,-0.008563362,-0.04731612,0.0048420206,0.015446632,-0.014636074,-0.03700938,0.023192769,0.009096051,0.06751577,-0.04115637,0.0163942,0.033571646,0.034397297,-0.057786703,0.044736154,-0.0441716,-0.009331459,0.013961522,-0.12527561,-0.044534776,0.09112148,0.07840134,0.001972793,-0.058068387,-0.043557543,0.005587123,0.026821649,-0.08560154,0.04264657,-0.0033695977,-0.09421968,0.059968203,-0.080575496,-0.04070531,0.04734413,-0.0203599,0.06975657,0.0075450833,0.025148707,0.11116943,0.056774218,-0.003988783,0.012373288,-0.027118599,-0.024654651,-0.008945907,0.03634617,0.0028284483,0.016196933,-0.022364361,0.03795579,-0.012766244,0.020321658,-0.09289135,-0.08795277,-0.008664908,0.10802774,-0.09069484,-0.010001936,-0.007033199,-0.029969001,0.07451758,-0.089182444,0.023210928,0.014968499,0.038878307,-0.02377493,0.020887017,-0.034569994,-0.040608633,-0.055092156,-0.052491207,0.03350744,0.035436142,-0.07454048,0.008083984,0.021880373,-0.0075141834,-0.038527954,0.0056312033,-0.039537963,0.052796178,-3.678436e-33,0.08920604,-0.045453195,0.0741164,-0.072270595,-0.053355906,0.12016276,0.10885017,-0.08396302,-0.019189505,-0.099379934,0.024869835,0.022304613,-0.019640004,0.005026697,-0.020258062,0.056052342,0.024138851,0.056892134,-0.005689804,-0.04631706,-0.037662797,0.17019212,-0.050048195,-0.0114259245,0.094039775,-0.02312436,-0.046664372,0.09396152,0.051114984,-0.03099136,0.017317412,0.031386316,0.010712068,-0.0292046,-0.05193508,0.056485463,-0.1188752,0.020914631,-0.0357489,0.11193057,0.02478907,0.014429292,-0.01947841,0.0430171,0.036129426,0.07654694,-0.10782046,-0.0070792544,0.09124154,-0.051110603,0.06408837,0.02001818,-0.03163047,0.043286618,0.01723555,0.041629966,0.009603465,0.03531271,0.04155407,0.0077998503,-0.014022963,-0.041682243,0.023589745,0.015126984,0.071922034,-0.036549397,-0.01208855,-0.024447383,0.032131862,0.018417412,0.06954306,0.016912155,-0.011297379,0.031837128,-0.055858385,-0.11011525,-0.11028571,-0.01495554,-0.032442536,-0.011233272,0.04541409,0.026406309,0.04336516,-0.022528436,0.0076623373,0.01665193,0.0013800618,0.062327612,-0.04287629,0.008185443,-0.008590754,-0.018431453,0.004717308,0.043416616,0.07893301,-4.353748e-08,0.08225514,0.035145245,-0.008963145,-0.03221912,0.021199565,0.009367097,0.01801272,-0.029478323,0.0558566,0.030867686,-0.042720377,0.117975675,0.06052259,0.042014584,0.037007604,-0.06835155,-0.030253023,-0.0061356067,-0.030307377,0.016562153,-0.062027384,-0.016603947,-0.1985681,0.061558433,0.023013156,-0.038430914,0.062656164,-0.0035901773,0.029740706,-0.06116389,0.011224242,0.047572546,0.101360865,-0.019243326,-0.03260752,0.07242245,-0.078694396,0.028249243,-0.008343078,0.02458448,-0.033834197,-0.09711646,-0.03654107,0.056179512,-0.050839335,-0.039542846,0.040392637,-0.048234,-0.012488542,0.01826159,0.053139552,0.013755861,-0.043835375,-0.09411921,-0.048528817,0.027204325,-0.0033549431,0.021977551,-0.020377398,-0.08317039,0.10077917,-0.04404268,0.065949,-0.09340723 +1.1.1.431,"Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH (e.g. the enzymes from Saccharomyces cerevisiae, Aspergillus niger, Trichoderma reesei, Candida tropicalis, Saitozyma flava, and Candida intermedia). Some D-xylose reductases have dual cosubstrate specificity, though they still prefer NADPH to NADH (cf. EC 1.1.1.307, D-xylose reductase [NAD(P)H]). Very rarely the enzyme prefers NADH (cf. EC 1.1.1.430, D-xylose reductase (NADH)).",384,1.0,-0.010991112,-0.024320504,-0.059636977,-0.052107144,0.033355553,0.043142855,-0.06788972,0.022472521,0.04083334,0.012673687,-0.029523198,0.028585095,-0.084119976,0.055256445,-0.02410304,-0.006068484,0.010719724,-0.0024312197,-0.010033795,-0.008083444,0.12666433,-0.020564217,0.06644975,-0.0010850468,0.06367336,-0.07826348,-0.0004862555,-0.07562353,-0.057546474,-0.096124806,-0.08603134,-0.055614445,-0.014165135,-0.038829736,0.029417733,0.060250606,-0.013441236,-0.0147797745,0.043630358,0.013675153,-0.0040943064,-0.027611211,-0.06726178,-0.019364314,-0.08341833,-0.02180925,-0.051426977,0.057717007,0.007878749,-0.013008214,-0.02626654,-0.02640698,-0.025004938,0.025576372,0.108196154,0.025944026,0.0010836658,-0.01006382,-0.021147624,-0.046393897,0.027701996,-0.007751896,-0.0058694994,0.00268129,0.009914377,-0.083665594,0.080098756,-0.028481659,-0.024733452,-0.02294675,-0.09613505,-0.016924506,-0.0030140616,-0.004745555,0.034833368,0.027314425,0.038069624,-0.067290924,0.0060214205,-0.008878755,0.05676386,0.07459043,0.03729053,0.016769743,0.07850332,-0.034958914,-0.065178365,0.0065128817,0.006427435,0.004053564,0.024133053,-0.010917314,0.037917055,0.054715034,-0.08598167,0.0009133119,0.097954474,0.076518424,0.05579246,-0.09168952,-0.001816778,0.056215834,0.059165526,-0.042241435,-0.0538164,-0.02831909,-0.0037051362,0.1405627,0.0032043543,0.015005899,0.0056959935,-0.022497825,0.031162998,0.02960843,-0.08448408,0.06670464,0.0113865845,-0.004474502,-0.098036006,-0.051307574,-0.008443853,0.0035036257,0.055984262,0.020038074,-0.010774823,0.026015572,-0.088039495,4.1133868e-33,0.07137592,0.10091425,-0.049418416,-0.025433384,-0.0047226404,-0.009272044,-0.06649844,0.06751866,-0.016607227,0.022874242,0.017009327,-0.074337065,-0.02863703,0.0072184796,-0.0050085317,-0.008977021,0.037908178,-0.037467673,-0.015585385,0.032023896,0.037609458,0.07078773,-0.05781855,0.037750624,0.028799042,0.025829144,-0.03262104,0.059446402,-0.053470075,-0.00039721743,-0.009076541,-0.122333266,-0.018083481,0.076580614,0.0893081,0.007691364,-0.09221147,-0.027921923,-0.008327994,0.00872253,-0.064761735,0.027542923,-0.0013454834,-0.0992497,0.04600611,-0.06370019,-0.04434156,0.06758274,0.014367515,0.07345433,0.018022178,0.019401474,0.101903066,0.06759597,-0.009420047,0.0474606,-0.043783586,-0.047890842,0.006360538,0.026052168,-0.0071564172,0.012988867,-0.023127565,0.032439265,-0.021407498,0.021276522,-0.06409456,-0.092061386,-0.041890536,0.09406828,-0.07305825,-0.032285947,0.020100486,-0.0041191597,0.052315947,-0.06272864,0.02436543,0.007597285,0.07528719,-0.020851556,0.020322358,0.004219264,-0.05151483,-0.050500683,-0.039439194,0.031444877,0.022279613,-0.043993913,-0.0041391267,0.037749473,-0.005591085,-0.05694445,0.012132411,-0.023289423,0.0644768,-4.7075852e-33,0.10666136,-0.030889148,0.04535954,-0.093295336,-0.06463505,0.11064445,0.08963233,-0.13072297,0.013254407,-0.11237664,0.0033829203,0.03541706,-0.026629416,0.012333291,-0.024409626,0.05391929,0.02469208,0.0431895,-0.021669786,-0.026298035,-0.00789173,0.14148816,-0.03779846,-0.020773292,0.106620096,-0.033344444,-0.04845536,0.08037599,0.05112142,-0.017580358,-0.012355762,0.009487285,0.0062324535,-0.036240995,-0.0698439,0.030569574,-0.13921492,0.0408255,-0.030777112,0.12372752,0.015508528,0.03161115,-0.038496923,0.02472809,0.056720052,0.082979396,-0.122099996,-0.00077685737,0.07411345,-0.024954155,0.044373903,0.019049166,-0.020827837,0.021797188,0.0073325816,0.051824372,0.043957323,0.028266883,0.024421684,-0.004252311,-0.012389696,-0.031175137,0.055940986,0.022689328,0.054783106,-0.04428115,-0.012602994,0.020306205,0.030419795,0.020642446,0.05646749,0.0072958036,-0.0069746883,0.043598875,-0.042708114,-0.10351415,-0.11443105,0.00960968,-0.039104834,-0.0073008398,0.029747654,0.032705676,0.045175094,-0.029320529,0.0033001306,0.0043109744,0.012524377,0.04735905,-0.032992724,0.009929733,-0.033286665,-0.016882645,0.014226291,0.038743787,0.0705884,-4.4733678e-08,0.05420668,0.010753933,0.02505789,-0.05138025,0.040138654,0.010287663,0.0156066995,-0.038877897,0.04929689,0.020022001,-0.062760085,0.1128742,0.08641619,0.033175036,0.021823237,-0.02913068,-0.0152938,-0.007576439,-0.034368202,0.01817361,-0.069637015,-0.020471506,-0.19363959,0.07982476,0.01830493,-0.06462776,0.07696232,-0.017805122,0.011042988,-0.016282609,-0.025185183,0.048667457,0.10061999,-0.010467993,-0.034017097,0.069090895,-0.06052281,0.008989162,-0.0051900526,0.033808906,-0.031695873,-0.07501552,-0.019287955,0.05703266,-0.02113162,-0.036410574,0.031831425,-0.016429972,-0.014092978,0.04057821,0.034243934,0.0045978306,-0.043471523,-0.097490765,-0.04391642,0.043198798,-0.0076281843,0.011509186,-0.008647564,-0.07988533,0.078732125,-0.04173257,0.112150885,-0.10952573 +1.1.1.432,"The enzyme, characterized from alphaproteobacteria, is involved in a D-sulfoquinovose degradation pathway.",384,1.0,-0.08470649,-0.08521284,-0.11000968,-0.023638535,0.0046804594,0.015592569,-0.035551205,0.085819766,0.02259793,0.009255341,-0.006061844,0.06013536,-0.09207413,0.08335786,-0.052990746,0.08941051,-0.08269466,0.061905768,-0.012548684,0.027835535,0.038108766,-0.0012465881,-0.048219856,0.0021409118,0.025825642,0.056596007,0.08182205,-0.015547129,-0.0928545,0.018701212,0.04025223,-0.0556428,0.086997434,-0.019878758,0.07840714,0.099183396,-0.010864957,-0.082287535,0.07659902,-0.032027587,0.05500254,0.04112866,-0.050021037,0.031406,0.00091158453,0.027077347,-0.054831672,0.059927512,0.09020136,-0.058787435,-0.06123682,-0.07088572,-0.049116556,0.035228286,-0.011505545,0.06509681,0.08495002,0.031258564,-0.031701706,0.045149338,0.014469216,0.026702622,0.03446598,0.014741842,0.034426227,-0.024056805,0.044679053,-0.020101715,0.02982329,-0.024446636,-0.12799858,-0.039406516,-0.045803204,0.05109306,-0.055430714,0.045929354,-0.011099119,-0.057582702,0.025236623,-0.07957612,0.084964484,0.010652136,0.08707561,0.0613781,-0.004391291,-0.0036362584,0.04611669,-0.082294494,0.12337177,0.032024615,-0.020377718,-0.0060624555,-0.004032337,-0.07972698,-0.054217283,-0.004617258,-0.017672826,0.042863917,-0.01968183,0.009013841,-0.0194655,0.04593782,-0.04139593,-0.110707305,-0.082037784,0.0011961677,0.013311564,0.065372,-0.0029170173,0.038151663,-0.016643256,-0.021925662,0.041708827,0.009848718,-0.009267131,0.039416905,0.05477388,0.040512748,-0.116339885,0.036855265,-0.045537405,-0.018538663,0.07481945,-0.008413433,-0.0553834,0.047573928,-0.05544231,-1.7345413e-33,0.098401286,0.005709416,0.0077464087,-0.0018330924,-0.032802146,-0.026786989,-0.09493266,0.022914708,-0.005633475,-0.02797062,-0.02979686,-0.11843027,-0.010708203,-0.022462947,0.020748468,0.05057718,0.016931884,0.02186076,0.024327522,0.0051932754,0.00030438672,0.035606246,-0.008380663,-0.08203826,0.064267784,0.06478227,-0.032296162,0.04583888,-0.024043731,0.003655928,-0.020156978,-0.08699176,-0.16318913,0.02920477,0.04912331,-0.03343479,-0.05713297,-0.038768943,0.0141224535,0.02919429,-0.050950993,-0.0068202023,0.029582242,-0.051059637,0.061724287,-0.04935146,-0.013613348,0.09541402,0.01662057,0.043599762,-0.00043534325,-0.056520447,0.09255886,0.008233872,-0.023586854,-0.055583183,0.0030543865,-0.033735033,0.070220724,0.010411151,0.054167137,0.049529783,-0.044214856,-0.0056990716,0.014892394,-0.05301175,-0.04714883,0.010407877,0.00082751946,0.036171976,-0.0013686009,-0.05122172,0.005035114,-0.01207622,-0.034371983,-0.07567684,-0.024303606,0.0054848855,0.025538256,-0.009287081,-0.07157375,-0.042408332,0.013753966,-0.034424976,-0.074577235,0.068927705,0.023623554,-0.017272182,-0.09159297,-0.0077371644,0.037132967,-0.04571542,-0.13188119,0.07182919,0.07399417,1.2516348e-34,0.06350243,-0.051391818,0.022419047,-0.09859746,-0.07036785,0.018973878,-0.010735735,0.07814045,0.014334473,0.0043964516,-0.0019370458,-0.019078588,0.011110449,-0.086002,0.0077992757,0.00091934664,0.01565563,-0.020763302,-0.0029897385,-0.0216373,0.031670216,0.117432475,0.0074712443,0.019169545,0.028947137,-0.01742538,0.021299047,0.098419674,0.05557205,0.0812176,0.030621381,0.07376792,0.0040997597,-0.014518191,-0.03644571,0.060688596,0.0026382715,-0.010882215,0.0077480273,-0.006545764,0.030109448,0.008104788,0.0052349158,0.05094913,0.0267319,0.06409968,-0.04382213,0.034189746,0.074974455,-0.03557717,0.07393021,-0.037527364,0.022171145,0.044067595,-0.0293335,0.036305405,0.0006462654,-0.005525842,-0.1242679,-0.013877672,-0.009190093,-0.040309634,0.02037722,0.013754189,0.015685176,0.073059045,0.020620184,0.075325854,0.056692477,-0.060556114,0.05415546,0.002991153,-0.03378278,0.045989875,-0.05413271,-0.0710747,-0.10623972,0.047830507,0.05712168,0.046115793,-0.012621073,-0.0073663155,-0.030354947,-0.0062985644,0.01169724,-0.10891725,-0.034745216,0.07280032,-0.055958074,0.029539764,-0.013002269,-0.017975338,-0.07816043,0.061372258,0.0031250003,-2.3378956e-08,0.07643209,-0.04793785,0.07610548,0.003034461,0.042755093,-0.013016394,-0.042505898,0.0493705,0.10101124,0.03950516,-0.04181634,0.059889328,-0.028732268,0.045650773,0.02426664,0.017484138,-0.030977907,0.010932473,-0.04533022,0.012463682,-0.0075978334,-0.071965896,-0.09596509,-0.0027265237,0.027516533,-0.08360032,0.06121227,0.019969597,-0.07042486,0.007839198,0.0009932884,-0.013579667,-0.018937834,-0.05034876,-0.03864166,0.07675698,0.012796125,-0.10995867,0.018860009,0.020790853,-0.026115194,-0.0037165007,-0.08085398,0.051046554,0.030843653,0.024920588,0.030312428,0.011933366,-0.047584053,-0.044241235,0.062934585,-0.015671061,0.015903307,-0.056286108,-0.11874799,0.038455233,0.06062168,-0.015402167,-0.013262015,-0.021086397,0.034769163,-0.0736056,0.1398831,-0.053185683 +1.1.1.433,"The enzymes from the bacteria Bilophila wadsworthia and Clostridium sp. MSTE9 catalyse the reaction only in the reduction direction. In the bacterium Bifidobacterium kashiwanohense the optimal reaction pH for sulfoacetaldehyde reduction is 7.5, while that for isethionate oxidation is 10.0. cf. EC 1.1.1.313, sulfoacetaldehyde reductase (NADPH).",384,1.0,-0.014785379,0.027703565,-0.018225957,-0.04540324,0.009940093,0.062287766,-0.05955427,0.0072751953,0.04431438,0.06466833,0.01691435,0.03039274,-0.037480343,0.055881087,-0.04145075,0.070425086,-0.049829356,0.03441275,0.008203872,-0.027607115,0.09116532,0.016997863,0.023167418,-0.011425689,0.081317924,0.022828054,0.024294749,0.0008851339,-0.04777417,-0.05410809,-0.012773501,0.020598901,0.046093177,-0.10115464,0.021426558,0.04359319,-0.06751494,-0.02825459,0.08712686,0.016677191,-0.03118533,0.07016118,-0.055115923,-0.08868,-0.07081379,0.031695712,-0.003368301,0.005536284,0.03747712,-0.058171023,-0.036054563,0.0045538675,-0.09218038,0.058853388,0.05939816,-0.047530524,-0.012739285,0.009831373,0.055361416,-0.09071675,0.022846388,-0.021285927,0.030475093,-0.013060336,0.026492197,-0.06971363,0.042634096,-0.09577981,0.015316709,-0.035898592,-0.09552325,0.03139057,-0.0037630524,-0.033711936,0.05391658,0.049496826,0.01769175,-0.034582667,0.026121449,-0.0040734783,-0.013124283,-0.03510776,-0.050042074,0.028073978,0.050057918,-0.07092676,-0.006095532,-0.043702643,0.0377302,0.0017568311,0.032607492,0.038388055,0.016469192,-0.079496086,-0.044729777,0.025775002,-0.035499852,0.094046675,0.020111078,-0.04758425,0.033236075,0.031052858,-0.039957087,-0.09537378,-0.061384175,-0.053963117,0.054217886,0.10869854,-0.0004895118,-0.050204296,0.01222468,-0.026946552,0.07341195,0.011067661,-0.023698991,0.06742012,0.11377818,-0.047330562,-0.09622807,0.017896848,0.021481097,-0.023889447,0.04620325,-0.012156093,-0.034946516,0.041289687,-0.1315987,5.835926e-33,0.108073846,0.10526298,-0.002146908,-0.075156994,0.04981033,-0.0014732075,-0.11477192,0.0018419112,-0.008051554,-0.107076064,-0.015039976,-0.042944852,0.028096102,-0.04862915,0.0074242377,0.016102592,-0.016660165,0.00740929,0.048886813,-0.0023395517,-0.00035434024,-0.043050926,-0.011110528,0.029738802,0.062174223,0.018095119,-0.002260224,-0.0029485999,-0.060387373,-0.013097738,0.084685475,-0.09821311,-0.09634094,-0.021714443,0.0029852323,-0.038139213,-0.038899187,-0.031631656,-0.011815328,-0.01589717,-0.031796545,0.058329787,0.020681761,-0.01620024,0.027655,-0.043239143,-0.050188437,0.118739136,0.0937072,0.13082305,0.016792124,-0.02947519,0.10046791,-0.040619276,-0.079972416,0.035716146,0.049904097,-0.039665874,0.02124737,0.08973972,0.033059478,0.08091048,0.005461052,0.007439174,-0.026426854,-0.032902874,0.02141303,-0.0015609333,-0.0064187446,0.0020397028,-0.072962835,-0.021071633,0.039773826,0.009135693,-0.048588436,-0.03990405,-0.0037059367,-0.047219954,0.04150615,-0.05776183,-0.016925111,0.067798756,0.044596586,-0.04506493,0.026107136,-0.053774126,-0.0907448,-0.0020296369,-0.012680166,0.032210793,-0.02854644,-0.085083194,-0.056127496,-0.009419528,0.015968442,-4.590662e-33,0.09011924,-0.040790234,0.04201147,-0.08249106,-0.044091225,0.038667485,0.079229616,-0.0072268276,0.03645113,-0.05675879,0.03979509,0.033213962,0.07697828,0.00915359,0.057382993,-0.018147781,0.11803843,0.020015083,0.039969973,-0.047037903,0.030292789,0.100106314,-0.011546946,0.019496836,-0.009723427,0.03792689,0.0076939273,0.023817565,0.089818455,-0.0011958996,-0.012422177,0.0354107,-0.06907954,-0.027465139,-0.01550166,0.0122308,-0.06454441,0.02921464,0.018523613,0.06939551,0.041724566,-0.027052078,-0.08562404,0.009188728,0.025374195,0.0015849711,-0.07882437,0.006113955,0.041978333,-0.028592203,0.012055852,0.06486151,-0.024934078,-0.0016813363,0.024233056,0.034256414,0.0024568976,-0.009086885,-0.0016198452,-0.06868676,-0.072197564,-0.01856224,0.057043504,-0.043691564,-0.06640394,0.107665196,0.028903712,0.0550269,0.047591995,-0.13376962,-0.017641729,0.014094501,0.010970186,0.013710419,-0.06208025,-0.042623725,-0.015167796,0.09087431,0.102099515,0.09269123,0.016916642,0.02604428,0.0040073385,-0.081278995,0.025139717,-0.080111854,-0.061466854,0.072164215,-0.010957757,-0.03370646,-0.03148903,-0.026803114,0.08439451,0.03831877,-0.0044449293,-3.928852e-08,0.014874119,-0.03161232,0.10508388,0.03578636,0.0069803293,0.00958997,0.00901163,0.025655204,-0.004553636,-0.026950907,0.035326287,0.038528915,0.033365764,0.025592048,0.036137465,0.033232078,-0.08696772,-0.0323864,-0.044993576,-0.014897843,-0.08456118,-0.0068737133,-0.11226362,0.117150284,0.05203699,-0.025827914,0.04653377,-0.10468981,-0.06121035,-0.0047654863,0.019793984,0.046873424,-0.0308285,0.0032438005,-0.043836482,-0.053124234,0.023149017,0.028404975,0.0007568991,0.03853428,0.00020208898,-0.009263696,-0.10056655,0.014732228,0.031267058,0.01289559,-0.0210492,0.011228015,-0.050575264,-0.0040173354,0.069921695,-0.002073647,-0.0011203429,0.0019025346,-0.08228525,0.031065559,0.07552913,-0.103701584,-0.06470526,-0.019910617,0.091461845,0.0013604406,0.14711685,-0.025249992 +1.1.2.11,"This bacterial enzyme acts on D-glucose, D-galactose, D-glucosides and D-galactosides, but the best substrates are disaccharides with a glucose moiety at the non-reducing end. It consists of two subunits, a catalytic subunit that contains an FAD cofactor and an iron-sulfur cluster, and a ""hitch-hiker"" subunit containing a signal peptide for translocation into the periplasm. A dedicated c-type cytochrome protein serves as an electron acceptor, transferring the electrons from the catalytic subunit to the cell's electron transfer chain. cf. EC 1.1.99.13, glucoside 3-dehydrogenase (acceptor).",384,0.99999994,-0.09836673,-0.062943496,-0.08387574,-0.05006623,0.04737856,-0.011391689,-0.007895274,0.040194787,0.04432502,0.022971649,0.02642989,-0.015152457,-0.04474833,0.07100581,-0.038335446,-0.01335644,-0.026369035,0.00848867,0.050663985,-0.035888217,0.032962315,-0.010994035,0.0044817626,-0.043691028,0.09044005,-0.0020169488,0.06258362,-0.05632644,-0.1085068,-0.034522697,-0.030909466,-0.049205802,0.045946915,0.011098712,-0.002298208,0.11935435,-0.035466924,-0.048517495,0.024811346,-0.046589736,0.017797848,0.04256372,0.02687345,-0.02501092,-0.049399547,-0.035776284,-0.034115538,0.062857725,0.022760963,-0.080322124,0.030312058,-0.044456676,-0.029029807,0.052988462,0.013133093,0.06297401,-0.042832572,-0.07722977,-0.0028420943,-0.046978347,0.020732423,0.013587612,0.010064398,0.03271019,0.011042073,-0.12843579,0.00678687,-0.065526836,-0.018690336,-0.062474012,-0.06984789,-0.08749301,-0.028365875,-0.03256118,0.01708607,0.0030597341,-0.0051065814,0.0035140282,0.05755981,-0.053482767,0.025550367,-0.0067600436,0.0725031,0.13764378,0.046753902,-0.06568402,0.030718505,0.023210822,-0.02347591,0.02237838,-0.017379975,-0.03612017,-0.022808364,-0.010953026,-0.104700804,-0.005573021,0.06769848,0.023373744,0.039654784,-0.049902324,0.039580394,0.100492254,0.059946533,-0.07297275,-0.060370937,0.0020551125,0.008111582,0.16378126,0.029113414,-0.038399544,0.003277432,0.019886537,0.021542681,-1.75623e-05,-0.06886786,0.07768056,0.06014961,-0.08345503,-0.006217915,0.012451474,-0.02558993,-0.023377368,0.05552384,0.018318173,0.0022993926,0.05261485,-0.07596943,-8.10536e-34,0.024263764,0.0056189774,-0.02286226,-0.03175419,-0.0016904931,0.024925398,-0.09090523,0.0016373952,0.007202367,0.028694874,-0.13439612,-0.039420594,0.06492889,0.08176195,-0.025567492,0.0043449183,0.008304311,-0.012918786,0.0857329,-0.0027491464,0.066998325,0.07190269,-0.009519886,-0.07451934,0.091175795,0.05600798,-0.056523625,0.0748129,0.02053954,0.0069459486,0.029209789,-0.08430337,-0.041474096,0.0063342103,0.05348962,0.026131157,-0.058020655,-0.019723013,0.022138879,-0.011044044,-0.0018965026,-0.014248003,-0.005090456,-0.054912183,0.047970846,0.014681233,-0.013737809,0.014656269,-0.021820933,0.11907885,0.07521643,-0.081123516,0.04044128,-0.060572412,-0.082116716,0.062450815,-0.0028634365,0.019465584,0.023462532,0.058473,0.0052253213,0.08927399,-0.06754328,0.05369931,0.06954747,-0.0067155617,-0.05839571,-0.046395045,-0.066195585,0.10043821,-0.13760872,-0.02114176,0.08152565,0.009192378,0.007111413,-0.040793765,-0.07925122,-0.0025378417,0.08253991,-0.018624812,0.0025783372,-0.025196096,-0.0098964665,-0.052246016,-0.011183327,-0.0016714172,-0.05182206,-0.119496964,-0.019589128,0.036828257,-0.008242275,-0.060779206,-0.06094819,0.0712099,0.02274729,-2.563338e-33,0.084177785,-0.085356265,0.07918412,-0.10872818,-0.029265694,0.094913125,0.042885613,-0.029205343,0.069085374,-0.0064095724,0.051545817,0.031436604,-0.028676538,0.00087286497,-0.007901927,0.05579446,-0.073702864,0.038835566,-0.08358195,0.013610843,-0.007029376,0.07427472,0.03378395,0.022829985,-0.0040013036,-0.0026463217,0.032104228,0.023862353,0.055955496,0.014253192,0.008281593,0.0133670475,-0.014884521,-0.07356754,-0.034267087,0.038464323,-0.06428185,0.030912215,0.026549013,0.0016242976,0.017605146,0.041523196,0.007841602,0.053481042,0.08584596,0.058404356,-0.082008,0.031092703,-0.008667121,-0.018989198,-0.028326238,-0.05550717,0.033945624,0.042624928,0.064307615,0.07067643,0.082486965,0.013013815,-0.011303753,-0.025925843,-0.07278916,-0.09270525,0.079174936,-0.0094558885,0.049009014,-0.027592976,-0.039050058,0.032468032,0.025528034,0.011673903,0.01930089,0.0071501704,-0.02924094,-0.018612932,-0.028575355,-0.03254332,-0.055988796,-0.020243634,0.037698396,0.007792551,0.0310623,0.017479887,-0.007867371,-0.030530598,0.047062974,-0.115736336,0.020575516,0.07675138,-0.024334695,0.0054264353,-0.0076118167,0.061116602,0.042327825,-0.0012272432,0.0692725,-4.327163e-08,0.013342644,-0.035621617,0.012486388,-0.045523528,0.008453881,0.04600771,-0.025203522,-0.040101554,0.012882074,-0.029370377,0.0039904015,0.16919383,-0.048571974,-0.001221307,0.0038359074,0.04143833,-0.04962285,-0.05707486,0.019577134,0.031394545,-0.07554688,-0.02614661,-0.11214941,0.020632043,0.037009075,-0.0869121,0.075685896,0.038167182,-0.052995577,0.0009823437,0.0037913062,0.06671155,-0.013881451,-0.0014222946,-0.036629938,-0.0396052,-0.041249566,-0.06665046,0.0044393498,0.04689263,0.089905046,0.0009529814,-0.05572199,-0.012691188,-0.03372736,0.04667371,-0.043060143,0.04025445,-0.073497154,0.07984173,0.0061427457,-0.056847174,-0.029229205,-0.067091756,-0.06052222,0.008324815,-0.04447172,-0.08244215,0.0046259128,-0.044998836,0.07086948,-0.002115945,0.111494996,-0.020258024 +1.4.1.28,"The enzyme has been shown to react preferentially with short-chain ketones such as cyclohexanone, primary amine groups attached to secondary alkyl groups, or D- and L-amino acids. It also reduces aldehydes to primary amines. Cosubstrate preference depends on the substrate.",384,1.0,-0.014741631,0.010753598,-0.06542745,-0.039234534,0.07537945,0.10516895,-0.10955177,-0.016394868,0.004115302,0.006628398,-0.0008583638,-0.008781165,-0.07877838,0.056827627,-0.05239956,0.07764208,-0.008503615,0.022579849,0.005484525,-0.09499107,0.023030354,-0.055328254,0.0142944865,0.024634812,0.026716886,0.01160148,0.019329673,0.008473235,0.038834997,-0.07286328,0.0010765833,-0.045971043,0.0125619015,-0.047905013,-0.002091592,0.06665203,-0.03548533,-0.049418736,0.025268322,0.06369568,0.0078016086,0.020495454,-0.013936748,-0.034185518,-0.046787795,-0.014752472,0.017392512,0.025265506,-0.027952632,-0.027193535,0.031546533,-0.09186204,0.006832554,0.050295718,0.025863886,0.04315779,-0.11328973,0.007858758,0.020474281,0.032231014,0.07866503,0.014652463,-0.06942317,0.04329799,0.044235557,-0.046925012,0.0481918,-0.063326895,0.016007077,0.0022400715,-0.012137128,-0.08261137,-0.010954588,0.040851112,0.04282201,-0.023371512,-0.039986536,-0.059665777,0.018331634,-0.01704354,-0.0021408275,0.03921729,0.0047953245,0.06293638,0.045656294,-0.04270806,-0.039720763,-0.011600906,-0.035720605,0.020748658,0.06235053,-0.038629133,0.019006386,-0.037300076,-0.07011617,0.026026316,0.08063177,0.10344386,0.012277537,-0.014801587,0.0006206046,0.01313708,-0.038488183,-0.04634194,-0.11828632,-0.046826765,0.08337303,0.08166286,0.04792903,0.035030145,-0.07023124,0.054516498,-0.011305006,0.0146059375,-0.04210691,0.11571887,0.11027807,-0.04985084,0.0053637745,-0.029829355,0.009748447,-0.0035358486,0.10303981,0.073427804,-0.01733334,0.09412756,-0.09198616,3.5906658e-33,0.08955776,0.0047895266,-0.03796056,-0.07772207,0.0371773,-0.071090065,-0.063900284,-0.00871192,0.014698313,-0.078942195,-0.043260634,0.02829513,0.06572523,-0.00019419639,-0.029156968,-0.031666882,-0.027397793,-0.005266965,0.03463651,-0.018410757,-0.016040111,0.07268224,-0.060306016,0.103415355,0.018608049,-0.010396411,-0.03497956,0.03092623,-0.02730858,0.014462875,-0.05137698,-0.040305097,-0.09164379,-0.03204875,8.3083716e-05,0.026254686,-0.110660344,-0.039723992,0.019231172,0.016433805,0.030751111,-0.010470087,0.012016514,-0.009550427,0.03229249,-0.022002375,-0.04235072,0.10015342,-0.025937587,0.046188597,0.104230486,-0.020661486,0.008690695,-0.0050507435,-0.0693112,0.10640607,-0.024473948,-0.076723635,0.062599674,-0.014763292,-0.07492638,-0.0010270921,0.016920812,0.026991518,-0.018018076,0.0050504506,-0.048849136,-0.07643086,-0.046074584,0.03088647,-0.11256083,-0.014219761,0.023851188,0.05612174,-0.008372303,-0.04849097,-0.03128878,-0.03001125,0.04813364,-0.02839611,0.047674425,-0.030545523,-0.0015513889,-0.031471,0.00985908,-0.06499667,-0.039231576,-0.114079565,0.019554079,0.018732259,-0.027247978,-0.051794592,0.017491626,0.021004878,0.026417255,-5.612712e-33,0.11460341,-0.12080854,0.035437446,-0.03824015,-0.10861164,0.06753975,0.08344599,-0.084998615,0.0376884,-0.027847933,0.053603258,-0.022270834,0.0016884372,0.016969483,-0.0018882353,0.049046613,-0.020505132,0.026164973,0.03676233,-0.05030745,0.044281784,0.07003256,0.0006292685,-0.022928601,0.05931321,-0.010918896,-0.08855345,0.0416202,0.10223628,0.016666869,-0.048718553,-0.034267142,-0.034046628,-0.06937085,-0.004707327,0.09808869,-0.09091149,0.03215696,-0.048891548,0.065299,-0.023493664,0.03726126,0.016361678,0.05413404,0.066811815,0.07315195,-0.074770115,-0.046583775,-0.033018775,-0.025055202,0.038753826,0.03994291,-0.046315964,0.056887753,-0.002144073,0.096732415,0.0403665,-0.023327889,0.0008028411,-0.0105972355,-0.065721035,-0.04794548,-0.014594787,-0.06748896,0.0086888075,-0.0022249888,-0.06446935,0.068997964,0.059227202,0.003728795,0.04200122,-0.049919803,0.072324306,0.031237287,-0.054984335,-0.0731119,-0.04684515,-0.0013241532,-0.038013898,-0.01694751,-0.033102736,0.04621751,0.03707892,-0.0595869,-0.03941174,-0.037572652,0.012821775,0.084848374,-0.012275629,0.05973187,-0.008349344,-0.002587566,0.06867433,0.073126115,0.05190934,-4.246884e-08,-0.024135526,-0.021092298,0.09359145,0.01768385,0.030924575,0.052611534,-0.0041444846,-0.008131112,-0.0041306443,-0.072998375,-0.03322475,0.08519342,0.02449295,0.09148347,0.00081596477,0.016803436,-0.022659443,-0.038673006,-0.016823683,-0.038817678,-0.110190675,-0.00090351736,-0.06654026,0.08832692,-0.03231052,-0.0028666633,0.07117584,0.108979456,-0.0499547,-0.010783136,-0.039135084,0.10164896,-0.014223018,-0.04692122,-0.028360587,0.082311764,0.0024647254,0.01136322,-0.030951865,0.02706371,-0.022468433,-0.038964424,-0.079751216,0.04356959,0.02880925,-0.034338906,0.04101291,0.008383347,-0.039710168,0.054511465,0.097583294,-0.0692063,-0.02140038,-0.009346626,-0.016372744,-0.031089984,-0.04036007,-0.08120929,-0.009836813,-0.10632341,0.011749398,0.016387817,0.14799842,-0.04531123 +1.5.3.25,"Reducing sugars such as glucose react with amino groups in proteins via the spontaeous Maillard reaction, forming an unstable product that undergoes spontaneous rearrangement to a keto amine compound. These reactions are known as glycation reactions, and the stable products are known as Amadori products. This enzyme, which contains an FAD cofactor, catalyses a deglycation reaction that regenerates the amine reactant. By-products are glucosone and hydrogen peroxide. The enzymes have been reported from fungi and bacteria, but not from higher eukaryotes. Specific enzymes differ in their substrate specificity. cf. EC 1.5.3.26, fructosyl amine oxidase (fructosamine-forming).",384,1.0,-0.057775512,-0.030025838,-0.07214529,-0.022852823,0.051280085,-0.0153293805,0.014908517,0.08236884,0.035550535,0.003116762,0.05547697,0.05718933,-0.066657774,0.012973676,-0.091257244,0.05606963,-0.027509058,0.006720124,-0.048708882,-0.028889379,0.15003534,0.004995835,-0.025984176,0.0132129155,0.0030778085,-0.046787694,0.046248455,-0.05826002,-0.048995204,-0.049873084,-0.009821257,-0.029914826,0.050042655,-0.06938999,-0.00034564125,0.11579272,0.016132688,-0.089676835,0.023677602,-0.023908073,0.024297299,-0.029364599,0.002640449,-0.08798653,0.06246578,-0.015736302,0.013454269,0.06062197,-0.03206626,-0.008400699,-0.050823715,-0.06561368,-0.026093965,-0.048876423,0.08556355,0.009509955,-0.10501296,-0.051103447,-0.010187738,0.044114813,0.025786553,0.0040291534,-0.053230956,-0.02334574,-0.030148512,-0.07340278,0.06403855,-0.08667094,-0.015254174,0.0018112853,-0.0152001055,-0.061793946,-0.015480447,-0.020272532,0.06213968,0.047475044,-0.04458031,-0.043978654,-0.005519921,0.017291168,0.036367077,-0.0057191304,0.071085446,0.025699338,-0.00022012486,-0.04377764,0.07296312,-0.01672142,0.038565036,0.02676909,-0.01161503,-0.015197214,-0.012076905,0.0070196786,-0.075043075,-0.0047987574,0.085302226,-0.034063775,0.074079186,0.0067279884,-0.03601897,0.0119783655,0.0056536095,-0.058574103,-0.08582212,-0.019650906,0.012313554,0.10148598,0.034233913,0.05798252,-0.036101297,0.029526325,-0.0185535,0.011537539,-0.07466465,0.0331538,0.019231515,-0.038679615,-0.009063964,-0.026298841,-0.01755434,0.090895005,0.077662416,0.052583147,-0.03529339,0.043406393,-0.038757637,2.6628591e-33,0.03500653,-0.040290505,-0.07084365,0.0068343207,0.05286083,-0.0054149264,-0.11173181,0.061982572,0.06825684,-0.03722603,-0.064174965,-0.026319308,0.026503002,0.011815216,0.014395967,-0.011538394,0.02774622,-0.023018816,0.10775115,0.012349559,-0.004553054,0.0064784717,-0.012664127,0.033050638,0.00052240613,0.020506557,-0.016188575,0.02818035,-0.009414725,-0.012261969,0.068037845,-0.06139886,-0.06442262,-0.09436618,0.050699104,0.061085287,-0.06361492,-0.008988276,0.016992686,0.06673037,-0.00948729,0.024102127,-0.014743725,-0.047755312,0.016148051,0.04160043,-0.016776254,0.11165301,0.026238138,0.052302334,0.004462191,0.0055002803,0.07933539,0.042922646,-0.076281704,0.029972134,-0.024774993,-0.04009288,0.0749426,0.060258333,-0.043104097,0.11703274,-0.007165459,0.02012016,-0.071810514,-0.030174663,-0.058989607,-0.023982951,-0.014351812,0.06546718,-0.02496452,-0.013531475,0.093848296,0.011182724,0.04646972,-0.12807888,-0.07620976,0.008031564,-0.0027744547,0.011739756,0.06402244,0.01594813,0.0026431135,-0.073993854,-0.080050714,0.009248163,-0.09529219,-0.01652885,0.019627573,0.07136027,-0.060876697,-0.081250705,-0.011084709,0.0064336746,0.031413313,-3.994964e-33,0.07449582,-0.16069432,0.058305632,-0.040978633,-0.008028407,0.03991476,0.01984592,0.003672436,0.043216232,-0.08127979,-0.00072410266,-0.0041469866,0.06921813,0.03508252,-0.004337747,0.06671216,-0.07386811,0.06272605,-0.0068290103,-0.018045528,-0.039394997,0.08272418,-0.061196648,-0.013010961,0.078947075,0.013956683,-0.0041714506,0.08128757,0.02733044,-0.009167486,-0.013279453,-0.060995582,-0.025285918,-0.04525909,-0.036771245,0.046049114,-0.075754516,0.006622153,-0.0009828971,0.028863491,0.05827344,0.073905565,0.052497134,0.0751464,0.06270204,0.08450605,-0.08221884,-0.010181291,-0.010966752,-0.041668065,0.011870529,0.015810844,-0.051668514,-0.050868034,0.050467048,0.05269968,0.0212544,-0.016329955,-0.028798,-0.0064216508,-0.03797141,-0.09904297,0.086147286,0.012130479,0.09574178,0.030854516,0.014211595,0.03857798,0.06727679,0.0004607654,0.10520969,-0.034340594,-0.0021110054,0.0052102045,-0.010324349,-0.04663391,-0.076479696,0.00209054,-0.023548787,-0.06809767,0.01861655,-0.02431178,0.019968426,-0.015462212,-0.05944931,-0.06114024,0.041417755,0.08165511,-0.027000098,0.057147488,-0.004020959,0.048246376,0.024368456,0.038271863,0.093170784,-4.3260634e-08,0.023231022,-0.08534287,0.04834975,0.03505282,-0.009058707,0.060256053,0.049753103,0.023827005,0.05743657,-0.08665566,-0.059157383,0.15063427,-0.045834597,0.01544436,-0.018947754,-0.019813212,-0.070832714,0.042328995,-0.028383844,0.023814198,-0.117926754,0.034751758,-0.07836167,0.020131655,-0.058132138,-0.06873935,0.07170986,0.074622415,-0.048865013,-0.061434913,-0.025111696,0.09364801,0.069235295,-0.020100154,-0.06604486,-0.033819363,0.019594336,-0.010351873,-0.04514865,-0.028844047,-0.02331548,-0.043835796,-0.04682516,-0.001830876,0.0005245253,-0.019267336,0.027330447,0.006661624,0.006876836,0.055477854,0.015452601,0.04530011,-0.0153097985,-0.018135514,-0.060215857,-0.055627044,-0.029965999,-0.085943185,0.003862898,-0.046015102,0.0010248405,-0.01211804,0.17464827,-0.007510023 +1.5.3.26,"Reducing sugars such as glucose react with amino groups in proteins via the spontaeous Maillard reaction, forming an unstable product that undergoes spontaneous rearrangement to a keto amine compound. These reactions are known as glycation reactions, and the stable products are known as Amadori products. This enzyme, characterized from a Pseudomonas sp. strain, cleaves the Amadori products at the alkylamine bond. All other known fructosyl amine oxidases cleave the ketoamine bond (cf. EC 1.5.3.25, fructosyl amine oxidase (glucosone-forming)).",384,1.0,-0.0899885,-0.007507434,-0.051528405,-0.00096129626,0.03080723,-0.023878379,0.016498702,0.047717463,0.038744796,0.0074044657,0.0673962,0.026206708,-0.038517296,0.028858082,-0.11874651,0.10060342,-0.0088887075,0.008001524,-0.05057194,0.05282761,0.1570499,0.033948824,-0.02997163,0.032085467,-0.026043618,0.002325392,0.06311362,-0.04481148,-0.029739404,-0.041206393,-0.03673992,-0.03964654,0.057352714,-0.0737796,0.032110855,0.12199502,-0.010264052,-0.09391095,0.055967182,-0.04539273,0.038903855,-0.03636737,0.013370939,-0.103507474,0.059517313,-0.06494074,8.9112305e-05,0.06709726,0.0064889262,-0.00026511372,-0.05405504,-0.071985126,-0.026167074,-0.0080380095,0.10739443,0.009543242,-0.1519526,-0.05690172,-0.018773668,0.068418205,0.052590407,0.029725173,-0.076173745,0.0055864677,-0.032326918,-0.0681953,0.09133957,-0.0483184,-0.014980831,0.01398699,0.0043124063,-0.04170987,-0.0052807024,-0.02760968,0.08356395,0.038782462,-0.039375648,-0.048882112,-0.020614278,0.0042792247,0.0039316784,-0.014859039,0.06538761,0.03913643,0.008016926,-0.037566993,0.046554312,0.0022836693,0.06387688,0.0010613207,-0.04245241,-0.021371597,-0.029891819,-0.023426238,-0.06426607,-0.021917673,0.08933687,-0.051890794,0.038331687,0.04435739,-0.02596958,0.017026385,0.009777277,-0.0803969,-0.08851669,-0.024968816,0.038684167,0.045231983,0.0022349176,0.04649293,-0.022782838,0.009783163,-0.018780237,0.011470413,-0.087874904,0.04667007,0.016308201,-0.015934387,-0.008576031,-0.017588712,-0.02799369,0.08199421,0.042028554,0.0645552,-0.04612169,0.017978916,-0.036364853,3.131655e-33,0.032116897,-0.036276396,-0.030989176,0.017013714,0.04674557,-0.015560232,-0.09437268,0.042335436,0.03519757,-0.060740475,-0.040693276,-0.00602443,0.035870522,0.009811899,0.044047505,-0.034368996,-0.0039538485,0.014873247,0.13076276,-0.00453405,-0.019586131,0.018642744,0.0002456739,0.014493592,-0.021048525,0.008095029,0.0046802037,-0.0045984313,0.006613084,0.0051982678,0.062283643,0.02288687,-0.067911215,-0.1090558,0.020852221,0.07340246,-0.073425785,-0.034267217,0.023035152,0.10156103,-0.038936008,0.03804673,-0.032874398,-0.052086417,-0.014495722,0.04469216,-0.014085135,0.08390963,0.019739008,0.04241266,0.0038580785,-0.02947201,0.032097097,0.05563112,-0.09530911,0.020012377,-0.0056607407,-0.05312,0.05069254,0.05263401,-0.040946,0.050221708,0.0010448928,-0.02508337,-0.073420994,-0.030215858,-0.07372522,-0.024941277,-0.016048988,0.052452315,-0.02446765,0.0246075,0.048356764,0.0095138755,0.05207172,-0.106937416,-0.08310826,0.02998171,-0.034810234,0.032725237,0.06658216,0.0047213603,0.023217041,-0.053066578,-0.08905278,0.0076738247,-0.058672715,0.0069497004,0.0050043417,0.05396391,-0.049141742,-0.08247199,-0.008736694,-0.018286379,0.030082949,-4.152615e-33,0.08906142,-0.1634726,0.08244651,-0.012717575,-0.004038455,-0.0034731964,-0.009228947,-0.005779344,0.0075888475,-0.07653079,0.023909532,0.02680574,0.086154126,0.054763757,0.014131557,0.05921612,-0.04452662,0.03467412,0.012697877,-0.054222215,-0.027361395,0.035629056,-0.04918372,-0.038818236,0.06299233,0.014058637,-0.048783794,0.09008562,0.025815684,0.02013112,-0.025446478,-0.075600006,-0.051954612,-0.04180545,-0.0060281474,0.119871825,-0.06128161,0.010870558,-0.0030720143,0.024137624,0.06379568,0.08359812,0.049792785,0.057453107,0.046506718,0.06938516,-0.05274667,-0.046005398,-0.0073320703,-0.073132105,0.023057489,0.046792727,-0.0717513,-0.0566877,0.029082855,0.03998105,-0.019809136,-0.021320619,-0.050706808,-0.029692091,-0.06248194,-0.07977506,0.06320318,-0.020310633,0.08737867,0.03991717,0.05447312,0.01996276,0.04319438,-0.012983607,0.114532895,-0.038943443,0.031004848,0.02994311,0.013959022,-0.047187474,-0.04987193,-0.03422487,-0.04617754,-0.08493841,0.040864434,-0.046616707,0.030252038,-0.017613027,-0.05222834,-0.015246978,0.058617715,0.085278675,-0.039468016,0.057307344,0.015249887,0.07175994,0.053222187,0.07501149,0.08671645,-4.1468695e-08,0.034771923,-0.09558389,0.036460534,0.057506517,-0.009207861,0.07419998,0.025924876,0.025922842,0.052443597,-0.08581997,-0.051625483,0.13132372,-0.01453982,0.051267967,-0.045478784,-0.011040109,-0.07553595,0.03263654,-0.014395076,-0.03573796,-0.13287367,0.017297883,-0.05829734,0.0053024637,-0.06371588,-0.053903505,0.055591237,0.04750384,-0.04822535,-0.055964045,-0.011739167,0.08659349,0.066918716,-0.010589023,-0.057994973,-0.01946482,-0.0043915045,0.0148077505,-0.025976233,-0.042886198,-0.0013548803,-0.023955476,-0.045582674,-0.00042094177,0.03499248,-0.0041975267,0.026144732,0.025912669,0.014290025,0.03519239,0.0058456906,0.039802723,0.009001588,0.009234734,-0.046320476,-0.0909276,-0.030652141,-0.04590539,0.03091909,-0.05239459,-0.014137052,-0.024078261,0.13792346,0.029094853 +1.5.7.3,"This bacterial enzyme is involved in degradation of glycine betaine. The enzyme contains non-covalently bound FAD and NAD(P) cofactors, and catalyses the demethylation of both N,N-dimethylglycine and sarcosine, releasing formaldehyde and forming glycine as the final product. The enzyme can utilize both NAD+ and NADP+, but the catalytic efficiency with NAD+ is ~5-fold higher. The native electron acceptor of the enzyme is a membrane-bound clostridial-type ferredoxin, which transfers the electrons to an electron-transfer flavoprotein (ETF).",384,1.0,-0.055061575,-0.022015886,-0.09310181,-0.007498411,0.09520937,0.025428275,-0.044813536,0.03664218,0.032440085,-0.015463547,-0.038999096,0.096373975,-0.012979346,0.09001328,-0.08241378,-0.011536399,-0.015002746,-0.025851354,-0.0146179395,0.014107016,-0.03780367,0.04715037,-0.000998221,-0.078031845,0.040046625,0.02460207,0.045384362,-0.06334366,-0.029158749,-0.027075866,-0.0136256935,-0.013106943,-0.016854221,-0.055711534,-0.03361061,0.09625567,-0.03806797,-0.025946945,0.06791709,0.007140153,-0.013306843,0.0061462405,-0.01392857,-0.065408096,0.0011545117,-0.0025596048,0.026214754,0.034573596,0.069798626,-0.005198762,-0.01403622,-0.00782051,-0.04391853,0.0409248,0.045410257,-0.039604157,-0.076537125,-0.061758664,-0.021592315,0.00042819002,-0.03317756,-0.020310681,0.02843051,0.012160339,0.017300477,-0.11847773,0.028830994,-0.07354906,-0.020634077,-0.052613076,-0.06693709,-0.033576023,-0.035272706,-0.03789006,-0.0054761926,0.008914249,-0.04734786,-0.03235514,0.08688756,0.0041101384,0.020923803,-0.05000223,0.021390563,0.08281984,0.043493647,0.058146283,0.0068550496,0.025522336,-0.027978875,0.029288547,0.01075247,0.01989459,0.020043308,-0.00554985,-0.07800701,-0.024441678,0.031364042,-0.003941562,-0.037183918,-0.005884718,-0.073029466,0.08894339,0.0015042562,-0.046561264,-0.07163143,-0.014648253,0.03747838,0.15346518,-0.0032138478,0.0012615926,-0.0014452109,0.040258642,0.05244248,-0.0038684648,-0.010035987,0.13803133,0.021063158,-0.012893434,-0.05040938,-0.031094683,0.009582878,0.009626528,0.019790899,0.05960306,-0.028191373,0.10151399,-0.08094388,3.1359078e-33,0.091823794,0.07211205,0.00655603,-0.039136305,0.03320616,0.0157906,-0.11539136,0.023898838,0.034264658,-0.008838968,-0.03184494,-0.051308043,0.04523344,0.006720644,0.022260642,0.030471422,-0.04661671,-0.041875545,0.07466967,-0.01547626,0.08637014,0.044314403,0.037985723,0.031519584,0.12126191,0.0047780103,-0.010675298,0.09738415,-0.03042325,-0.0026006326,0.036375992,-0.10405758,-0.09296165,-0.04889991,0.032563396,0.013756819,-0.069666155,-0.05887009,0.032930627,0.025606126,-0.009744318,0.01639126,-0.020161903,-0.0027883588,0.0050473814,-0.03436467,-0.0096088955,0.07008584,-0.036061104,0.058352437,0.07729987,-0.07324187,0.08416449,-0.012415093,-0.06171774,0.060705546,0.031454034,-0.043624986,0.011736702,0.07384859,0.032681666,0.024933917,-0.0237016,0.0011911286,-0.014756146,0.008729051,-0.06473565,-0.03896286,0.020856285,0.031063672,-0.013038993,0.010917868,0.09868665,-0.0049089175,-0.0042524026,-0.054218322,-0.03997477,-0.05136657,0.108932205,-0.03823774,-0.011760363,0.027955031,-0.023009993,-0.027445614,0.0012112336,0.028509649,-0.0035694307,-0.09021057,0.015814383,-0.0069998777,0.069753036,-0.07650316,-0.045662086,-0.050172303,-0.016822355,-3.1617338e-33,0.096221894,-0.11804073,0.028595606,-0.050469473,-0.0152994,-0.009138993,-0.00032228685,-0.033411473,0.04408703,-0.07975049,-0.017492285,0.030103702,0.057197675,-0.015549498,0.041060075,0.0045673554,-0.021749951,-0.016815314,-0.04739767,-0.082878016,0.02746945,0.03460823,0.062651716,-0.012448017,0.019786796,-0.01879719,-0.040417656,0.04987125,0.10232287,0.055363204,-0.031360734,0.020996336,-0.07642584,-0.058707964,0.0033823196,0.07205217,-0.017130898,0.04842725,0.008548815,-0.06253387,0.0370464,0.011409379,-0.03589948,0.06587969,0.088070534,0.115105934,-0.074222066,-0.002889909,0.028032247,-0.04257956,0.04280366,0.0034775336,-0.024066359,0.04681323,0.042830788,0.042528573,0.057875175,0.04048916,0.018653803,-0.00804977,-0.0040425695,-0.09050894,0.0078954855,0.047350254,0.073027685,0.04054999,0.01748846,0.05734374,0.06414876,0.012314282,0.044735342,-0.023569794,0.024260037,0.05506421,-0.0065797917,0.015154768,-0.0617008,0.009523553,0.005925738,0.033517737,-0.002321501,0.02340434,-0.064276755,-0.03546084,0.008458029,-0.06516435,0.043963484,0.1480721,-0.00916085,0.011562665,-0.043179274,0.00804992,-0.0033841522,-0.005456622,0.01060386,-3.997616e-08,0.021824254,-0.061765738,0.07046192,-0.06409336,0.015097609,0.047562297,0.046597905,0.00072296045,0.037517108,-0.077089645,-0.07810503,0.16744918,-0.008148786,-0.016793245,-0.01862313,0.057357617,-0.067920215,-0.009257406,-0.02829608,-0.065616116,-0.10595356,0.028535966,-0.1080937,0.07688535,-0.04645158,-0.058695093,0.024595132,-0.010473358,-0.01882739,-0.060311068,-0.037457086,0.075500906,0.033912335,-0.06793092,-0.13489415,-0.015295174,0.024289552,-0.00013695267,0.03588212,0.066080496,-0.0009479991,-0.021937966,-0.08702272,-0.034845434,0.0013796439,0.048528995,0.02089756,-0.01399109,-0.0646484,-0.009250473,0.082553975,-0.0015787332,-0.019881131,-0.06713101,-0.12565222,0.033943087,-0.08893242,-0.06444888,0.07093615,-0.06506086,-0.04086286,-0.022597505,0.17803714,-0.013502989 +1.13.11.93,"The enzyme, characterized from the bacterium Pseudomonas putida, is involved in an L-lysine catabolic pathway. Contains Fe(II).",384,0.99999994,-0.0011059989,-0.08592688,-0.11240818,0.06774711,0.11968299,0.07939314,-0.07549873,0.037249707,-0.01521934,-0.07888675,0.019518087,-0.015845437,-0.003881956,0.053997535,-0.025002891,0.029211445,-0.10495966,-0.037140664,-0.0021101572,0.05458446,0.08454835,0.10427748,-0.03441714,-0.00029077378,-0.039743185,-0.019288782,0.05806194,-0.035206202,-0.04370488,0.0006424695,-0.061796788,-0.0382955,0.049468312,-0.0803279,0.029071903,0.012190896,-0.04883536,-0.020102454,0.078683905,-0.0131129185,-0.037201818,-0.06981375,-0.026641326,-0.049652472,-0.029005865,-0.014472688,0.05854255,-0.005874334,0.005610984,0.030215817,-0.052122515,-0.038108766,-0.019558337,0.056732174,-0.043984126,0.0027054963,-0.022508148,0.008976541,-0.021100823,0.032883573,0.016193058,0.03833495,0.005778788,0.072697334,0.0372302,-0.031118803,0.047817886,-0.051071376,0.014487271,-0.078272015,0.0031931626,-0.06542316,0.015472631,0.006467873,0.041831028,0.0026941407,0.08320507,0.019031536,0.066821784,-0.03881266,-0.016379418,-0.05456999,-0.013859226,0.10920545,-0.025039213,-0.009861752,-0.010596666,0.039870955,0.014750502,-0.0046370667,0.03254387,-0.03863456,-0.071531415,-0.028796304,-0.024316767,0.01141536,0.018473538,0.013361271,0.017640073,-0.028884519,-0.03396509,0.06744489,-0.010568061,-0.03436962,-0.031156592,-0.023669215,0.022901775,0.07919402,0.0011625888,-0.021736672,0.07891224,0.02276116,0.06788261,0.01442495,0.041567583,0.034285817,0.10565901,-0.055155028,-0.056534693,-0.027870921,0.056797862,0.021079961,0.031334646,0.11028747,-0.04868986,0.016324276,-0.14797556,-1.8798838e-33,0.05933831,0.031318072,0.029585598,-0.06839479,0.01739885,0.0049563088,-0.088770404,-0.008280196,0.0034737336,0.045701124,-0.085187964,-0.07132067,0.061888218,-0.017411029,-0.05033233,-0.043899503,-0.024889417,-0.04627241,0.09728735,0.030095438,0.03406849,0.08199602,0.01765911,0.00017561614,0.053038128,0.069628745,0.06282495,-0.011291638,-0.019547878,0.012645748,0.015322732,-0.11338935,-0.08047529,-0.044559207,0.04187504,-0.047421545,-0.013926468,-0.007157408,-0.0023939626,0.013286567,0.06595382,0.077247106,-0.022737138,-0.026370391,0.08841593,-0.065551154,-0.049310002,0.18837367,-0.026345514,0.1189834,0.038677942,-0.07659307,0.049753875,-0.032404676,-0.10365681,-0.022864917,-0.057497725,0.055140242,0.019865869,0.103365436,0.09977116,0.068050176,0.014026493,0.09008146,0.025711143,-0.047646206,-0.055507414,0.008044391,0.04627815,0.026684731,-0.108615935,0.05171847,0.09661965,-0.00043028904,0.044684943,-0.11533996,-0.12243795,0.007001002,0.061917994,0.03598544,0.016949952,-0.079453684,-0.0012963841,-0.0076761884,-0.05046558,0.016843542,-0.020900521,-0.042876355,-0.09147679,-0.022380764,0.032219347,-0.030332645,-0.01020419,0.04170737,0.025830014,-4.1571633e-34,0.031473264,-0.10544271,0.10407265,-0.06769779,-0.0104032885,-0.011501145,0.006511831,-0.033074092,0.05889237,0.016527452,0.06934718,0.0015440088,0.019418336,-0.10523166,0.029243784,0.04943189,-0.03988157,0.025729755,0.03055361,0.010859437,-0.022535084,0.017285401,-0.011844407,-0.009664168,0.102504835,0.019179726,-0.05231167,0.09309544,0.019507675,0.05634661,0.068447255,0.0098439995,-0.021787627,-0.12768923,-0.009537066,0.0049755704,-0.036110893,-0.01720774,0.10220183,-0.031375583,0.00923957,-0.006842974,-0.002153927,0.05357241,-0.036406852,0.055683296,-0.0866807,-0.016314259,0.022045193,-0.061664946,-0.030914621,-0.07931914,-0.028664788,0.0148831755,0.003761204,0.020335391,-0.024794744,0.066454425,-0.10418756,0.014191397,-0.0072588455,-0.051094905,-0.009785958,0.04324429,0.05215286,-0.026221724,-0.039005697,0.046511877,0.0129009215,-0.009327944,0.073544875,-0.0074561075,-0.0031654327,0.04129322,-0.080292374,-0.03241597,-0.0261106,-0.06512556,0.0031140728,0.029131958,0.018784726,-0.008036738,-0.0120642455,-0.03558782,0.024275096,-0.070327625,-0.011212415,0.09428367,0.016693925,-0.027732223,-0.029179765,-0.008996043,-0.0065155956,-0.046514146,0.036968246,-2.5563876e-08,0.041855603,-0.11331701,0.007274044,-0.012602397,-0.017290024,0.026206996,-0.039976154,-0.013503594,-0.042598274,-0.027602024,-0.003427615,0.06416592,-0.0047636535,-0.056673452,0.03141937,-0.012030061,-0.037568968,0.05456678,-0.02454619,0.01067842,-0.05055074,-0.06307696,-0.1148814,-0.007553951,0.03637165,-0.055768933,-0.030611265,-0.03147909,0.031489473,-0.040529013,0.01781184,-0.029620685,0.005704539,-0.034500755,-0.08596623,0.023807537,-0.016301222,-0.046299987,-0.016500037,0.04590528,0.03466238,-0.010820884,-0.045698,-0.011146139,0.03399874,0.009130837,-0.019721754,0.0291856,0.015171013,-0.041790508,0.053976584,-0.013141,-0.001851054,0.011332159,-0.03504871,0.07915306,-0.03044319,-0.009847294,0.049865462,-0.016298212,-0.0065154233,0.08598614,0.15774919,-0.04169683 +1.14.11.78,"Requires Fe(II). The enzyme, found in actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. The reaction comprises two catalytic cycles, each consuming an oxygen molecule and a 2-oxoglutarate molecule. In the first cycle the substrate is hydroxylated, while in the second cycle the enzyme catalyses a decarboxylation/oxidation reaction that produces an isonitrile group.",384,1.0,-0.053393062,-0.076584086,-0.065064296,0.074121766,0.025038445,-0.0002540288,-0.0048313746,-0.017883662,0.00967949,-0.0586719,-0.0025098224,-0.08247214,-0.07723744,0.022031596,0.007584677,-0.003353854,-0.0868086,-0.006413062,0.06608274,0.012059234,0.14858015,-0.012505374,0.0017384511,-0.06906617,-0.06504602,-0.016069252,-0.012386241,-0.038336273,-0.0066827745,-0.097346246,0.009435963,-0.04529347,0.12184165,-0.08971572,0.013720321,0.082998894,-0.02468716,-0.031085962,0.0625359,-0.0016703596,-0.044946272,-0.05457657,-0.048992604,-0.006923524,0.0004842171,-0.07674671,0.058837656,0.010205663,-0.00878364,0.027462952,-0.06498166,-0.02777233,-0.06339929,0.048473157,0.005421618,-0.02532093,0.06146522,-0.0064634825,-0.012078685,-0.050662182,0.059935786,-0.022688564,-0.05525323,-0.016695712,0.023717517,-0.05032734,0.061790183,-0.10154862,0.04784732,-0.01854353,-0.075702675,-0.026662638,-0.0820956,0.013203816,-0.06194429,0.012416818,0.02668787,-0.025952164,0.051741965,0.032710582,0.0037375372,-0.0038083175,0.0033715898,0.09105913,0.04978297,0.031222062,-0.03873562,-0.007991965,-0.029648777,0.08957447,0.0011230861,0.0054751253,0.012453172,0.0025791528,0.019921873,0.019126331,0.03292734,0.042689558,0.07447824,0.007864099,-0.052716628,0.017257951,-0.07752539,-0.067882635,-0.016583495,-0.0097078355,-0.06836541,-0.011513996,0.024131224,0.0709976,-0.012461731,0.00044298175,0.034740496,0.016427763,0.0037437426,0.05844523,0.08118311,-0.051669586,-0.00014225359,0.0295741,0.041432656,0.019056171,0.026548471,0.06112223,-0.0018284152,0.0024208294,-0.122786716,1.3853703e-33,0.05034598,0.006577298,0.015975453,0.022969527,-0.027375199,0.027622135,-0.05056993,-0.02208778,0.001969482,-0.02665097,-0.091856785,-0.11001873,0.062525384,0.00698386,-0.0065971436,-0.049885858,0.0016112138,0.012251919,0.12874404,0.0076885633,-0.016192121,0.05155322,-0.021520626,-0.020303925,0.013229224,0.055213455,-0.064054936,-0.015690625,-0.027728416,-0.013081187,0.06903687,-0.109780245,-0.09663405,0.023583675,0.12390865,-0.052768465,0.028408045,-0.019519232,-0.033351015,0.011966725,0.003363961,0.04477867,-0.001627557,-0.018022602,0.11088572,-0.0051935976,-0.058527168,0.14192732,0.09524026,0.107382484,0.03818119,-0.0017114175,0.113036506,-0.048535854,-0.039503492,0.041057546,-0.040663008,-0.04488223,0.043355405,0.07030532,0.03887729,0.029222408,0.07178596,0.0700012,0.007902658,0.040998407,-0.064161085,0.035860125,0.02831021,0.081811085,-0.08436554,0.02397072,0.08339971,-0.0132340705,0.0532126,-0.0247444,-0.056626372,-0.03580602,0.06867454,-0.00729129,-0.029144987,0.0020908816,1.571349e-05,-0.07966508,-0.054699074,-0.0028157656,-0.07803042,-0.04681088,0.0038261733,0.06437664,0.0060503306,-0.06520912,-0.15084156,0.034792088,0.06660968,-3.6900557e-33,0.09099077,-0.1004808,0.03915126,-0.10201447,-0.08108335,0.041402344,-0.018125283,-0.082253024,0.037667498,0.08201042,-0.006078393,0.0007375876,0.039025016,-0.041846503,0.005584587,0.0035781823,-0.030613614,0.038187217,0.03545831,-0.03475386,0.0072802263,0.08527897,0.0017223442,0.02514426,0.047435615,-0.02832752,-0.07425394,0.046867963,0.09868874,0.045142695,0.014073559,-0.056278434,-0.029441766,-0.09006995,-0.0022180628,0.048677415,-0.078618445,0.06702652,0.06412716,0.004083845,0.013114541,-0.00845285,0.0040175896,0.09389248,0.027493251,0.017080972,-0.0036671744,-0.0128800925,-0.0004893961,-0.04707763,0.036064833,-0.04353324,-0.035907608,-0.0060274554,0.04607,0.05382094,0.011653913,0.042419206,-0.0038950488,0.027432073,-0.004202007,-0.036953915,0.06222851,-0.027001102,0.042527266,0.03392766,-0.02991466,0.05769784,0.043854367,0.032615658,0.04108587,0.015739873,0.015344156,-0.00737299,-0.0017593775,-0.017371807,-0.035042953,-0.05398429,-0.052517436,0.019037684,-0.020882867,0.017212998,-0.013237075,-0.05587225,-0.06119082,-0.06400274,0.034930035,0.02328138,-0.039897412,0.028435593,-0.010025726,0.027181013,0.0037016016,0.012818218,0.008357487,-4.227268e-08,0.004157008,-0.018227512,0.0741029,-0.046640158,-0.01533268,0.025384445,-0.030475296,-0.060684904,-0.02428314,-0.020584524,0.012323218,0.0784009,0.0667653,0.009850375,0.07477451,0.0032881675,-0.0250887,0.0291501,-0.050801385,-0.013960061,-0.09728672,-0.023287112,-0.1287688,0.044949908,0.008527465,-0.086168095,0.012283345,0.007707617,0.03909665,0.02748629,0.024990086,0.044784117,-0.051862497,-0.024051175,-0.1113227,-0.0249402,-0.048278917,-0.100436345,5.653272e-06,0.0035867903,-8.644863e-05,-0.02116206,-0.048338924,0.007221246,-0.011188661,0.04928516,-0.09005107,-0.004993581,-0.040739916,0.046532623,0.071754456,-0.0077887923,-0.044278994,0.036249995,-0.04014979,0.11330315,0.021380141,-0.029677566,0.049306445,0.006371488,0.008153983,0.022042762,0.19451511,-0.05994119 +1.14.11.79,"The human enzymes encoded by the RIOX1 and RIOX2 genes catalyse the hydroxylation of L-histidine residues in the 60S ribosomal proteins Rpl8 and L27a, respectively. Both proteins contain JmjC and winged helix domains, and both also catalyse histone L-lysine demethylation activities.",384,1.0,-0.0075048436,-0.05889409,-0.0361064,-0.0314465,0.030357938,0.07299755,-0.061939433,0.022857543,-0.03583077,-0.024411473,0.0030946012,-0.0064631486,0.013633158,0.059806753,0.020485202,0.03110231,-0.14362484,0.01966012,-0.055434387,-0.07685321,0.098337725,0.034732696,-0.014387601,0.023805099,0.0017908661,0.027114758,0.102291465,0.008906064,0.0092025865,-0.06828319,0.038035303,-0.028503994,0.031566888,-0.07753116,0.04965237,0.009493636,-0.030469561,-0.07445296,0.07438692,7.7978504e-05,0.0017345969,-0.017082594,0.039992087,-0.010849901,-0.01569836,-0.023789037,0.028863896,0.038196772,0.043031145,0.11395745,0.0072030798,-0.019080708,-0.044713687,-0.017539458,0.0057573006,0.023234978,-0.07592888,-0.029176284,0.042637374,0.020269763,0.016153846,0.007725116,0.006826187,0.011126759,0.011609958,-0.1082215,0.019455468,0.01895667,0.048519436,-0.00916121,0.021059375,-0.087552056,0.04427791,0.070778206,0.05213864,-0.0151502425,-0.015306087,-0.037040465,-0.025320794,-0.020785214,-0.06003061,-0.02862467,0.0313012,0.063111946,0.008330898,0.01713266,0.023470238,0.02205677,0.055910464,0.056946706,0.041058727,-0.017945383,0.013161859,-0.037568014,-0.018097186,0.005521715,0.043008044,0.04677299,-0.0604125,-0.03533913,0.045705996,0.0028915976,-0.019639032,0.0341988,0.041735467,0.04048419,-0.012855065,0.090394855,-0.043388058,-0.05101995,0.03150689,0.03157068,0.00392701,0.03846303,0.02753734,0.07564246,0.0108464025,-0.08094449,0.0058791526,-0.09231562,0.0031520333,-0.005089397,0.028511513,0.048187543,-0.04398417,-0.030002747,-0.15544222,2.755558e-33,0.0051458688,0.024862956,-0.021441625,0.032530338,-0.08702987,-0.03837121,-0.089586794,0.0375468,0.0023833534,-0.04935867,-0.10655034,0.042700645,0.061319042,-0.0026855734,-0.079956345,-0.03012445,0.017649177,-0.056660153,-0.011898001,0.026190113,-0.01809363,0.058344953,0.0454793,-0.0008114665,0.014103078,0.03413857,0.020860298,-0.101571664,0.069277085,0.03776846,-0.08717952,-0.051887024,-0.026142834,0.07695677,-0.029063871,0.06077877,-0.015604313,-0.050301842,0.026038874,0.105556995,0.04990235,0.009191493,-0.029264655,-0.07131049,0.000559966,-0.032430753,0.01307259,0.032676008,-0.09548232,0.021650078,0.06486322,-0.0056611462,0.071576394,-0.059902303,-0.017832514,0.033020303,-0.032996308,-0.00048550608,0.016569408,0.078910805,0.027128616,0.013758419,0.022593752,0.09944265,0.07985604,-0.029176842,-0.025495745,-0.07603946,-0.03273468,0.051980283,-0.074815676,0.018858202,0.18560411,-0.008068067,0.03015598,-0.04348673,-0.08803734,0.0242826,-0.009788396,0.10169252,0.016087005,0.020853264,-0.04715377,-0.014808004,0.032679018,0.0022908165,0.09716325,-0.063156225,-0.031220483,0.07456616,0.0072363536,-0.08661956,-0.015903346,0.009885621,0.01714346,-4.7738824e-33,0.043498486,-0.14570749,0.06979239,-0.027985265,-0.061713472,-0.035930783,0.101656556,-0.023973878,0.025055023,-0.04950326,0.053405214,-0.019256268,0.01824231,-0.08918258,-0.005563421,-0.078141116,0.04113629,0.032868426,-0.047110546,0.004297069,-0.038143408,0.04843405,0.009335186,0.046006646,-0.048632026,-0.010817657,0.016420057,0.03486092,0.06360684,0.03587018,-0.074262165,0.03730354,-0.033566564,-0.093168996,-0.02485556,0.046336584,-0.084516875,0.019719703,0.047095936,-0.037692506,0.00615061,0.014745036,-0.03330618,0.05334589,0.01205593,0.090986535,-0.016130412,0.070921466,-0.020709775,-0.08064454,0.030689448,-0.040319733,-0.0409206,0.023814382,0.0018462302,-0.023448678,0.020695183,0.004610118,0.065974824,0.066202484,-0.036416825,-0.018938813,-0.015225558,-0.023718406,-0.03816949,0.039799877,-0.030800318,0.016469546,0.022346163,0.05891071,0.1153095,-0.039373156,-0.0034757496,0.060111254,0.03713562,-0.029324593,-0.12479931,-0.04205042,-0.023637272,-0.057252876,0.0022678575,-0.013196898,0.002643437,-0.020004278,0.092491336,-0.07826804,0.0016119519,0.12892242,0.04930363,-0.018462235,0.03053598,-0.055105615,-0.09569651,0.037657306,0.05066494,-3.4970327e-08,-0.014386929,-0.07809973,0.035790674,-0.024132678,-0.033168454,0.112712845,-0.048640497,0.04597832,0.07208867,-0.0045358823,0.02781498,0.03770853,-0.044244945,-0.0547881,-0.083669625,0.002439022,-0.058145333,0.091613926,-0.0024406705,-0.026761586,-0.031885043,0.022567814,-0.0072777336,-0.025983276,-0.031006223,-0.016623037,-0.04937244,0.022101527,0.058411334,-0.17051789,0.015366428,-0.009934484,0.006902681,-0.06292794,-0.028393695,-0.031093191,0.093974814,0.018789615,0.05826152,-0.05631259,0.045029413,-0.056687906,-0.10895579,-0.017626416,-0.028808458,0.028456617,0.002722452,0.03897966,-0.014948352,-0.0072042732,-0.009257327,0.006683994,0.032207686,-0.091436684,-0.0552595,-0.013031618,-0.057497874,-0.08393684,-0.0052985013,-0.09075638,-0.007949368,0.008071893,0.0813094,-0.07565008 +1.14.13.251,"The enzyme, characterized from the bacteria Pseudomonas aeruginosa and Chromohalobacter salexigens, is involved in a degradation pathway of glycine betaine. It is composed of two subunits - a ferredoxin reductase component that contains FAD, and a terminal oxygenase component that contains a [2Fe-2S] Rieske-type iron-sulfur cluster and a nonheme iron centre.",384,0.99999994,-0.04490516,-0.062480737,-0.12208457,0.017788056,0.094588585,0.05586359,-0.038377963,0.06668247,0.004603049,-0.056207415,-0.0140382135,0.039708067,-0.006712746,0.05232076,-0.10010987,-0.026112977,-0.048071545,0.011813641,-0.027502107,0.007172959,0.018911453,0.085282676,-0.03024218,-0.003191924,0.012080307,0.01576946,0.066037245,-0.036619857,-0.020132165,-0.0145240575,-0.021321852,-0.06694268,0.07410637,-0.027437147,0.026907593,0.08412591,0.043551244,-0.052026644,0.07629328,0.009505703,-0.0047903657,0.035833254,-0.041350257,-0.032942656,0.035062652,-0.0046019815,0.021905785,-0.004608225,0.08746253,-0.0019162244,-0.046652485,-0.054272246,-0.04869149,0.08192966,0.043910496,0.018523412,-0.042107232,-0.0790032,-0.0020229851,0.017624205,0.024508286,-0.007879358,0.011822224,-0.009469508,0.027459435,-0.03660184,0.028826496,-0.07992533,-0.013582965,-0.06550059,-0.009400141,-0.033236623,-0.04438849,-0.029110508,-0.02195901,-0.03124085,-0.015943512,-0.0036470585,0.050645996,-0.020402035,0.021822466,-0.06717093,0.09057879,0.06755612,0.01255855,0.016418995,-0.013613991,-0.017347531,0.020158902,0.027312163,0.0040432382,0.024248876,0.008551198,-0.071990736,-0.015636321,0.0043764133,0.018914571,-0.0075941132,0.032911368,-0.0003778126,-0.078660496,0.09873581,0.012875176,-0.07362778,-0.05159849,-0.013295087,-0.020302376,0.14700125,0.013800686,0.0067269495,0.007827509,0.03087017,0.03681284,-0.009866383,0.0012752613,0.05759911,0.059480138,-0.018720081,-0.07662104,0.051737826,0.05741761,0.004084652,0.034716908,0.07780648,-0.017965436,-0.008925916,-0.11800555,2.6491146e-33,0.06840633,0.044955213,-0.006984378,-0.041505482,0.0053553763,0.033591338,-0.13823777,0.0055250814,0.04275564,-0.02105888,-0.01681166,-0.045386896,-0.008794241,-0.015060435,0.057092074,0.003228094,-0.029642079,-0.024950271,0.0932788,-0.06491001,0.020108616,0.042527262,0.0113321645,-0.019351684,0.07786254,0.06228227,0.017941346,0.068253726,-0.03136437,0.0065896497,0.047609285,-0.096855916,-0.115358286,-0.0137254065,0.051882494,-0.016938409,-0.080383755,-0.02528336,0.015128008,0.048701692,0.04570033,-0.00024751195,0.0038040068,-0.011224798,0.06034241,-0.0408218,-0.008995339,0.105200715,0.034035098,0.09133972,0.006182679,-0.04877728,0.066504285,0.009209741,-0.079228185,0.032086156,0.0068668765,-0.019943014,0.009410882,0.070764564,0.042764276,0.048345562,-0.012186087,0.037547264,-0.013982873,-0.01970662,-0.07923162,-0.037175298,0.0053648627,0.051294632,-0.029746324,0.002469047,0.08372493,0.015900433,-0.03695706,-0.12255237,-0.039981097,-0.0015853246,0.037679177,-0.053153895,-0.060776558,-0.017807832,-0.04796079,-0.002795339,-0.06448781,0.037143856,0.05230855,-0.093500644,-0.011796104,-0.023087697,0.05701366,-0.065643914,-0.07834653,0.0107607385,-0.008779809,-2.7151895e-33,0.047728334,-0.12392356,0.06413979,-0.07905862,-0.04160495,-0.028649148,-0.0068891514,0.01301099,0.025342688,-0.011252101,0.01088536,0.024059443,-0.012045405,-0.041910578,0.015546545,0.06198322,0.0495301,-0.023477936,0.0052072243,-0.071044534,0.023633888,0.046928406,0.03329515,0.007076851,0.01915252,0.02925787,-0.023043381,0.0841904,0.10723117,0.094670504,-0.0053809914,0.059122305,-0.02954052,-0.06885948,-0.09245845,0.033705708,-0.020578872,0.02090038,0.04661654,-0.0717955,0.10390532,0.027613392,-0.045647036,0.08899352,0.06264723,0.1098192,-0.0016994578,0.0029575399,0.006938089,-0.097842336,0.017887298,-0.049192257,-0.011545258,0.05845058,-0.0074205683,0.03543988,-0.01981732,0.044021405,-0.032546014,-0.009042539,0.06850698,-0.06284792,0.024956318,0.06270061,0.08889331,-0.019761872,0.026049923,0.056213737,0.05168256,0.05867204,0.03991928,-0.04763865,0.034693174,0.048771277,-0.030402934,-0.015278375,-0.089462474,0.006713346,-0.0076987585,0.024994468,-0.004128895,0.04053726,-0.07141799,-0.006156292,0.012226962,-0.0985285,0.00074854324,0.1919381,-0.0114757875,-0.017105829,-0.047375426,0.032585055,-0.018165143,0.03862135,0.029569037,-3.8374747e-08,0.037949108,-0.077958144,0.050429706,-0.06999338,0.008212124,0.031391226,0.008046621,0.028858624,0.0014061446,-0.025812216,-0.09635779,0.101275146,-0.048653066,-0.081688784,-0.020023322,0.08351419,-0.11098437,0.0145490505,-0.017538765,0.0013049437,-0.041219413,0.028281694,-0.07295585,0.046769865,-0.07903415,-0.054812122,0.03775332,0.004257669,-0.074931905,0.00050053536,-0.008687185,0.05944145,0.031448245,-0.057817426,-0.15032369,-0.018126624,0.0021632565,-0.0121248085,-0.007378972,-0.004609649,-0.020140387,-0.0019199734,-0.09580398,0.007307125,0.015024773,0.01641635,0.028770057,0.026761362,0.020723341,-0.066918105,0.074745916,-0.019421797,-0.026533784,-0.057767633,-0.14282872,0.022980096,-0.04693013,-0.056148477,0.042214345,-0.016152436,-0.016510159,-0.023474425,0.14503255,-0.027032813 +1.14.14.179,"This cytochrome P-450 (heme thiolate) plant enzyme catalyses the C-6 hydoxylation of several brassinosteroid biosynthesis intermediates, and the further oxidation of the hydroxyl group to an oxo group. Substrates include 6-deoxocastasterone, 6-deoxotyphasterol, 3-dehydro-6-deoxoteasterone, and 6-deoxoteasterone. The CYP85A2 isozyme of Arabidopsis thaliana (but not the CYP85A1 isozyme) also catalyses the activity of EC 1.14.14.180, brassinolide synthase.",384,1.0000001,-0.15700197,0.046740267,-0.031551044,-0.03417867,0.040715925,0.10767001,-0.123894535,0.074939385,-0.024513641,-0.010113274,0.04637248,-0.022765957,-0.01435825,-0.14022082,-0.04407735,0.049218938,-0.09322244,0.05564422,-0.02602762,-0.114325844,-0.044593528,0.030335866,0.0062478557,0.026473554,0.049755618,0.04895391,0.03359691,0.062153175,-0.054053817,-0.026748674,-0.07037008,0.031364005,0.032516606,-0.014399192,-0.020225117,0.11237804,-0.03336081,-0.08128657,0.055482194,-0.029993642,0.034782603,-0.018743578,-0.04745538,0.0035817907,-0.05147036,-0.039603245,-0.017474359,0.035612073,0.01869257,-0.09367203,0.03590861,0.006320305,-0.012544664,-0.0022749978,-0.02330269,-0.03389237,0.044171084,0.032455534,0.044958808,0.025980651,-0.0345841,0.016385913,-0.00053486583,0.024043024,-0.019938702,-0.029018221,-0.019741505,-0.016386965,-0.025128705,-0.050430678,-0.03821454,-0.06953859,-0.11351505,0.022959866,-0.07778396,0.11626208,-0.016747532,-0.057597265,-0.0016600279,-0.009428588,0.021717897,-0.020854577,-0.013579921,0.047643054,0.014728796,-0.013739049,-0.04959547,0.041798465,-0.016461309,0.03327927,0.019814447,0.04569576,-0.023029506,-0.054432254,-0.03216621,0.12745011,0.018401429,-0.0051560025,0.020574033,-0.032472856,0.048844513,0.048938997,-0.07262427,-0.087705135,0.037543926,0.0066869534,-0.01589703,0.011616728,0.008681921,-0.060071304,-0.0113157425,-0.045812175,-0.010534413,-0.0113483,-0.034315582,0.060121015,-0.008872966,0.0015639141,-0.047986437,-0.035221502,0.003672018,-0.02830257,-0.03407974,-0.00621479,-0.05519909,-0.04409831,-0.11103331,4.9182408e-33,0.06179108,0.057992235,-0.016224006,-0.027895667,-0.027898284,-0.03193255,-0.03176413,0.012647193,-0.054400194,-0.011798644,-0.06793657,-0.04958961,0.022713518,-0.058956083,-0.021785099,-0.0037434981,-0.019645333,0.06890108,0.036088925,0.0083861975,-0.03437681,-0.037241075,-0.061899334,-0.0431842,-0.032191634,0.13099529,0.023996998,-0.04249906,0.011127532,-0.02393065,-0.08476813,-0.028876275,-0.013595654,-0.028484453,0.045441896,-0.069473125,-0.056264203,-0.014130158,-0.047888976,0.039491232,-0.029060695,0.04055188,-0.049701333,-0.018003663,0.062392488,0.03398846,-0.070285276,-0.0028135963,0.06645292,0.0761687,0.06289675,-0.008178601,0.12893157,0.044592362,0.0370499,0.01597806,0.01497777,0.028493615,0.03994982,0.057756532,0.072275326,0.11585759,-0.0286363,0.017145779,0.025895225,0.029038925,-0.10622274,-0.005420904,-0.03987818,0.16273314,-0.0075842077,-0.043704573,0.04720667,0.027776716,0.0802349,0.036696814,-0.017037604,0.06593243,0.04172753,-0.00715076,0.062391423,-0.001768265,0.039695375,-0.02215275,-0.005901555,0.0015065679,-0.07348335,0.015353487,-0.043999117,0.073088124,0.10294507,-0.08206161,-0.024530971,0.02090405,-0.034151867,-5.6865597e-33,0.08410485,0.02371612,0.007796505,-0.1504947,-0.0027784796,0.015857719,-0.018080272,-0.042261668,0.023359276,0.02755275,0.037587266,0.00750264,0.03060017,-0.019655062,0.0035775118,-0.033210095,0.05362762,0.11023509,-0.06254792,0.045108724,-0.045637015,0.003926769,-0.008071969,0.026767315,0.01415095,-0.026443271,0.0041022426,0.040974554,0.07980929,0.00065313675,0.00075864507,0.019780701,-0.040419005,-0.014898161,0.0021722284,0.06371744,-0.018431703,0.034833234,0.057289384,0.042029105,-0.045035664,0.017979933,0.011099653,0.09038378,0.046413198,0.04269754,-0.0581023,-0.013340779,-0.08800117,0.020830933,0.05356002,0.06413029,-0.026904281,0.038771324,0.018289303,-0.00084831694,0.033792023,-0.030779596,0.015063407,-0.062331785,0.018090533,-0.045713063,-0.009614979,0.077757366,-0.045910444,0.122306295,-0.0022689376,0.048795152,-0.05764009,0.056130093,0.061224908,0.017919445,0.038521446,-0.007384252,0.015433706,0.023557685,0.0065195453,-0.017656349,0.023021467,0.0196104,-0.0007332109,0.01892909,-0.035222836,-0.05496018,-0.034122508,-0.08753166,-0.05428531,0.11448613,0.0127319405,-0.0012115971,-0.018746002,-0.009307538,-0.04949828,0.06798335,0.07186831,-4.211894e-08,-0.025212798,-0.07049647,0.06250079,-0.038366076,0.022437554,0.022478817,0.03748381,0.036676615,0.072694644,-0.07242448,0.033566177,0.028743194,0.037926134,-0.05033157,0.041600153,-0.018084018,0.0144394785,0.026103785,0.019073395,0.06934265,-0.009545777,0.017709447,-0.059549417,-0.016290855,-0.0039022313,-0.09683675,0.03827881,0.011523442,0.016844412,-0.009064467,0.048943985,0.04576252,-0.10916104,-0.0092269555,-0.00967561,-0.03542771,-0.024834571,-0.030941803,-0.012116383,-0.02296895,-0.07873524,-0.060103197,-0.09404618,0.027281236,0.033602886,0.021074207,0.039196327,0.01907668,0.0040584337,-0.014512665,-0.034860466,-0.024417302,0.028056974,-0.138814,-0.044498853,0.03390901,0.07507236,-0.021677407,-0.08041472,-0.08786697,-0.042172477,-0.012870268,0.23234658,0.018227294 +1.14.14.180,"This cytochrome P-450 (heme thiolate) plant enzyme catalyses the lactonization of several brassinosteroids, including castasterone, teasterone, and typhasterol. The CYP85A2 enzyme of Arabidopsis thaliana also catalyses the activity of EC 1.14.14.179, brassinosteroid 6-oxygenase.",384,0.99999994,-0.08467839,0.021406515,0.003510996,-0.045627974,0.046567317,0.11137219,-0.07688373,0.11942324,-0.018591128,0.010352365,0.016061164,-0.009558651,-0.059541807,-0.09859702,-0.031002076,0.03801404,-0.06384429,0.08951469,-0.013795573,-0.14197043,0.01444132,0.014486478,0.029858373,0.013756859,0.06887315,0.034558073,-0.012656102,0.045875,-0.05157265,-0.05885764,-0.08070526,-0.021067783,0.047984954,-0.0054616043,-0.032877468,0.066017635,-0.017370105,-0.083830304,0.030953899,-0.004223344,0.089434646,-0.0432498,-0.061538875,0.013082314,-0.058050398,-0.038571957,-0.0065718526,0.048742387,-0.006888806,-0.08317318,0.008039931,-0.010290576,0.017418226,0.024658246,-0.043715384,-0.000110315144,0.036521446,0.0154715,0.049984217,0.031635806,-0.009719215,0.03382838,-0.018843288,-0.0055982335,-0.002900351,-0.0045036334,-0.03679482,-0.021686422,-0.024556799,-0.018328764,-0.0009735012,-0.07175785,-0.11169984,-0.00059411186,-0.07062307,0.11548672,-0.008768861,-0.041766196,0.01899804,0.013765967,0.0048618005,-0.02816571,-0.059590034,0.052518267,0.009220029,0.00035744146,-0.028469443,0.035723027,-0.0051588765,0.08054251,0.017267473,0.075405434,-0.041931063,-0.04666689,-0.05048874,0.09502067,0.024522413,0.019669408,0.013349722,-0.0077659637,0.049532566,0.06330231,-0.08580618,-0.12699427,-0.046832617,0.024696382,0.0024073117,-0.04405365,0.040794693,-0.10126998,-0.015517145,-0.0731056,-0.02476798,0.012329424,-0.055776548,0.06597156,-0.01743411,-0.017270666,-0.062002216,-0.008509534,-0.017431878,-0.054330654,-0.02825362,0.0051833424,-0.03846199,-0.042183764,-0.06836811,5.3917685e-33,0.069475025,0.040122807,-0.015520988,-0.052326445,0.0006441468,-0.008989857,-0.055666875,0.057728603,-0.08801444,-0.0056132525,-0.06014482,-0.070838965,0.00767734,-0.09235862,-0.002690491,-0.042244256,-0.015162041,0.0834438,0.042632136,0.0026502234,-0.03244182,-0.010532045,-0.057965502,-0.0032577717,-0.009746884,0.060671136,0.02746043,-0.043294225,0.028821692,-0.007897255,-0.03255397,-0.04088385,-0.053697567,-0.0007883007,0.006881903,-0.07143228,-0.043621738,-0.0177127,-0.053633053,0.030710878,-0.08200137,0.06253171,0.019152611,0.03428551,0.027028825,0.0123646725,-0.08457571,0.00999163,0.12024014,0.0662838,0.06996692,-0.0043375944,0.11123301,0.044509087,0.045724414,0.043091558,-0.027327657,0.081328146,0.027181841,0.040522892,0.0752423,0.08376387,-0.0033886374,0.008067836,0.023976086,0.0801387,-0.07794293,-0.06039341,-0.003720668,0.101654924,-0.020896059,-0.059727933,0.034821387,0.009594423,0.0781377,0.053381257,0.0014672193,0.022500064,-0.008376718,-0.030351069,0.022207515,-0.044882793,0.011061414,-0.0014989612,-0.03665841,-0.016549839,-0.07410923,0.011507173,-0.009224129,0.07383173,0.12437459,-0.06532812,-0.05164235,0.0051184627,-0.005934273,-4.0094004e-33,0.08394092,-0.02051364,-0.0059564277,-0.12749484,-0.046473633,0.011836814,-0.0553363,-0.03980058,0.013020261,0.029142143,0.060785815,-0.03399551,0.037286665,-0.022770407,-0.03793514,-0.049483407,0.087294154,0.086896874,-0.04863457,0.05369758,-0.0364588,0.044201355,0.009308162,0.041060988,0.035906993,0.01762504,-0.03963443,0.08104118,0.049053486,-0.015433348,0.025244543,0.055019896,-0.043498043,-0.036353163,-0.041385297,0.050524633,0.050876223,0.021257002,0.08234523,0.050332706,-0.04130624,0.033364408,0.049937334,0.070584305,0.04201676,0.030433953,-0.047904547,-0.014475954,-0.077183954,0.031565264,0.026840962,0.097914875,-0.045730688,0.0102492515,0.021078207,0.008670458,0.019252876,-0.043057557,0.011726856,-0.066768445,0.034098417,-0.050414696,0.006511775,0.039077837,-0.01002641,0.07715525,0.0076442813,0.043905083,-0.036140356,0.06179903,0.0769498,0.013871901,0.026753835,0.08583122,0.0017862723,0.033744257,0.052378807,-0.045427307,-0.002469265,-0.024028236,0.0198541,0.033603087,-0.040568102,-0.081468076,-0.0063910508,-0.054739174,-0.014604943,0.14641221,0.002975555,0.036404777,-0.030407013,-0.039019488,-0.03939294,0.07618481,0.05999917,-3.636046e-08,-0.0064828745,-0.06791511,0.04255464,-0.01913001,-0.004636565,-0.014600137,0.035646267,0.05427718,0.088352986,-0.11715423,-0.0015338522,0.055430654,0.05506423,-0.049471203,0.10168621,-0.023044042,0.04643565,-0.012638604,-0.005821631,0.036494903,-0.022361945,0.0027155476,-0.1025961,-0.024356749,-0.0036338032,-0.065663375,0.025400735,0.07312472,0.017080195,0.015280276,0.057683688,0.055268284,-0.016801283,-0.010632546,0.009812829,0.004648146,-0.06326256,-0.034475517,-0.019756539,-0.05985347,-0.07291216,-0.046259247,-0.04281903,0.024051435,-0.0005608466,-4.1533112e-05,0.06300029,0.016218858,0.04586386,-0.0061074616,-0.02270516,-0.046287436,0.013874328,-0.0970992,-0.046204872,-0.009443315,0.09871855,0.00029462366,-0.06658906,-0.08184354,-0.036339693,-0.019412408,0.20981999,-0.034952577 +1.14.14.181,"The enzyme, characterized from the bacteria Agrobacterium fabrum and Rhizobium oryzae, is involved in a D-sulfoquinovose degradation pathway. FMNH2 is provided by an associated FMN reductase [SmoA, EC 1.5.1.42, FMN reductase (NADH)].",384,1.0,-0.071407504,-0.04448621,-0.11914847,-0.010695666,0.07568373,0.025082627,-0.06886545,0.101240024,0.017573245,-0.030915659,0.010691257,-0.0028758047,-0.058165986,0.069188215,-0.07818337,0.07657245,-0.09839239,0.039953694,-0.045118265,-0.01993225,0.021900257,0.08814782,-0.013503302,-0.04854841,0.012077593,0.009974891,-0.0054659406,0.02456071,-0.08584413,-0.02474156,0.075515985,0.008297315,0.076556236,-0.018783811,0.06992559,0.03602703,0.04313754,0.0010401094,0.034510273,-0.024988428,-0.008288327,-0.013176325,0.015551037,-0.042614017,0.012737043,0.040328898,0.016611781,0.042033304,0.078465186,-0.036049247,-0.06838683,-0.0409805,-0.029082788,0.12874055,0.10624311,0.07679038,-0.0035950453,-0.029429216,-0.090177305,0.020785643,-0.029344002,0.03275039,-0.017111294,-0.036953215,0.0797979,-0.0020244215,-0.01696548,-0.10494744,0.007335503,0.02150006,-0.07254136,-0.068121485,-0.020278394,-0.042278085,-0.01322661,0.08008744,-0.021052243,0.010468413,0.05965273,-0.064996615,0.024134178,0.02062939,0.074851945,0.023945587,-0.0054807044,-0.038840428,0.015860729,-0.06998482,0.09733997,0.047209226,0.0063011097,0.013762735,0.0010150266,-0.07545811,-0.08724774,0.020054363,0.01453174,0.060953226,0.0376712,0.02940086,0.009231968,0.038131017,-0.057118695,-0.12522344,-0.12541701,-0.020849358,-0.00083811797,0.12163706,-0.0037047688,-0.019910254,0.0052084504,0.019996624,-0.0052562766,-0.0147473,-0.0317092,0.012590206,0.040854003,-0.0047292556,-0.10806718,-0.00092273287,-0.06435855,0.0015648887,0.022552313,0.05219754,0.027238911,0.022932762,-0.14669923,2.9947447e-33,0.06476688,0.033835415,0.003699404,-0.03980661,-0.022936366,-0.031592317,-0.082453966,0.051513206,0.017776374,-0.038801134,-0.054369535,-0.030574331,-0.016770339,-0.10573874,-0.031342175,0.011564711,-0.03770114,-0.048611753,0.041575935,0.0031854294,0.07839727,0.07295877,0.0045558563,-0.03337275,0.05341264,0.05126344,0.009589032,-0.0065251244,-0.030361963,0.03298107,-0.0014973594,-0.11277146,-0.098370664,-0.029516738,0.02774746,-0.028714657,-0.101024665,0.016921267,-0.046404537,0.080243684,0.0006322344,0.026124101,-0.029480178,-0.0031991177,0.06182387,-0.017436314,-0.011413996,0.13055865,0.07021248,0.10497152,-0.00028496154,-0.084590696,0.07351421,0.022365889,-0.007872631,-0.037084755,-0.016812941,0.008808856,0.026833411,0.027554693,0.0026093337,0.025847973,-0.05458689,0.020705037,0.0049379035,-0.035917137,-0.018793385,-0.00832751,0.030405419,0.0715064,-9.287527e-05,-0.02974762,0.04691559,0.026293505,-0.023185857,-0.09819905,-0.015246617,-0.0407577,0.04086367,0.0128513025,-0.028581379,-0.055016108,-0.044945214,-0.0611961,-0.07714758,-0.007698056,-0.042792395,-0.0377232,-0.098684855,-0.018118825,0.065531544,-0.07659036,-0.053554323,0.005235671,0.08764332,-2.9524078e-33,0.03462328,-0.047069237,0.020218037,-0.06605503,-0.018217525,0.014040969,-0.009528057,0.049294457,0.0007216813,0.006412138,0.0007122597,-0.005383371,0.010854779,-0.018773904,-0.014643306,-0.034779947,0.03153985,0.0024052542,0.021134872,0.014798327,-0.05078092,0.120085075,0.014407572,0.015685055,0.013835069,0.07042683,0.023296416,0.14272165,0.06250028,0.0712508,0.010886425,0.07589812,-0.04014818,-0.03312227,-0.01926108,0.02827198,-0.019392176,-0.0026738099,-0.02650544,0.019683309,0.060856987,0.053442344,0.004693545,0.056082,-0.023551786,0.080993064,-0.119495176,0.061478496,0.053227607,-0.06361305,0.049234375,-0.016133972,0.008630426,0.013568501,-0.004459014,0.043695986,0.01558597,0.021244548,-0.050468,0.03114142,0.00513615,-0.102493934,0.025212837,0.013808284,0.03631131,0.06112129,0.07215182,0.1079839,0.005028967,0.04265379,0.04767412,0.0027677887,0.042724967,0.04000865,-0.075635396,-0.014595789,-0.0683705,0.06727189,0.020973623,0.026500974,0.012090251,-0.0321127,-0.0077773957,-0.0339668,-0.014811235,-0.04304447,-0.0044301683,0.10151722,-0.041115925,0.022075536,0.0076781185,0.03685784,-0.032357305,0.05788562,0.014956158,-3.6257642e-08,0.042169888,-0.12779859,0.042192474,-0.023010135,0.05085391,0.011639702,-0.021087218,0.09000421,0.042580485,0.038719755,-0.028186295,0.09496292,-2.8271807e-05,-0.028544694,0.04649665,0.03735698,0.001628451,-0.0022422369,-0.053873494,-0.03223706,-0.05398202,-0.028316375,-0.113168605,0.00827195,-0.02397055,-0.04981023,0.07485247,0.02008202,-0.02933514,-0.039375994,0.009102338,0.017107185,0.00063271215,-0.023638217,-0.13305151,-0.005474864,-0.030992948,-0.11228836,-0.036906112,-0.014028277,-0.012716429,0.052114967,-0.06686636,0.032049168,0.014670751,0.001588074,0.0427824,0.039717097,-0.048621044,-0.060416006,0.0035765385,-0.009367423,-0.024689868,-0.04676989,-0.15035327,0.032829467,0.02778683,-0.003942239,-0.023617558,-0.010170446,-0.0061749923,0.0011589967,0.11718817,-0.0104094595 +1.14.14.182,A cytochrome P-450 (heme-thiolate) protein from the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis. ,384,1.0,-0.051292643,0.014776467,-0.08993492,-0.055253252,0.025816984,0.040897425,0.028788136,0.02900827,-0.0015585816,0.020316448,0.05840905,-0.019542357,-0.073391296,-0.027577905,0.017951593,0.013181879,-0.056589264,0.0108172605,-0.015321153,-0.061305363,0.083558634,0.061421614,0.012195462,0.015371456,0.011056406,-0.06309804,-0.039018817,0.03447752,0.0006727001,-0.11912653,-0.02814527,-0.0047507808,-0.047474284,0.026153678,0.022482999,0.06894892,-0.02885518,-0.04666731,0.020959238,-0.05757821,0.088321164,-0.008319307,-0.098934256,0.012784696,-0.07808719,-0.019499093,0.017055046,0.018551499,0.023734543,-0.020819724,-0.025951857,-0.077872284,0.0055066324,0.03494626,0.007724843,-0.009580949,0.00457651,0.011224485,-0.010325719,-0.06777636,-0.050645392,0.036735788,-0.01360006,0.011135127,-0.025164703,-0.007872253,-0.03234692,-0.036418468,-0.028745338,-0.07009017,-0.042295463,-0.059166826,-0.0054574283,0.055603117,-0.11910464,0.11136095,-0.0044755978,0.05781382,-0.015225858,-0.05850434,0.01754922,0.081779204,-0.0055297455,0.13567747,0.048044425,-0.04539995,-0.01971396,0.06120775,0.03833669,0.010551269,0.028655164,0.03582281,0.003364031,0.013351317,-0.110638894,0.05587719,0.06504511,-0.073333055,-0.0068885,-0.014930707,0.05272961,0.08421795,0.042729206,-0.11291745,-0.11513083,0.035934467,-0.11538558,0.053066082,0.027252309,-0.05777319,0.016758496,0.00022275042,-0.0010074077,0.014282409,-0.009435595,0.06973764,-0.018733094,-0.058741156,-0.02135447,-0.07325777,-0.04799795,-0.021763785,-0.0050742,-0.004497115,-0.045233913,-0.0033938906,-0.032053564,1.8085882e-33,0.074573025,0.0420952,-0.018103924,-0.034501154,0.07938968,-0.005532353,-0.050952483,0.05571139,-0.0783379,0.005108076,-0.12845205,-0.09949351,-0.0019024801,-0.09305424,-0.01233172,0.041177493,-0.06849237,0.04249237,0.03541815,0.024721965,-0.050058234,0.038080867,-0.008605953,-0.09086218,-0.018872617,0.11614529,-0.060625017,-0.03525059,0.022861669,0.02345172,0.008594188,-0.027283562,-0.0038956355,-0.012521415,0.032484632,0.010584174,0.019393716,-0.045965582,-0.05852385,-0.010413763,0.02320009,0.013024385,0.07167839,-0.042166848,0.033905365,-0.06881202,-0.07285736,0.04452192,0.0072366637,0.02444608,0.031503525,-0.040941454,0.10487633,0.022760805,-0.06936975,0.016310368,0.026553024,0.05956425,0.015964152,0.093528755,0.09132476,0.02529754,-0.060514614,0.017231226,0.0053998344,0.059709422,-0.08793244,-0.026809739,-0.036534116,0.115877606,-0.056811117,-0.04703914,0.01038685,-0.035456643,0.08464305,-0.026348993,0.0010505976,0.012685802,0.012104696,0.12582934,0.018881802,0.01800503,-0.0812596,-0.040625796,0.0033298049,-0.037915297,0.060218878,0.066985615,-0.020175328,0.016684303,0.048018567,-0.047492288,0.016432133,0.018186344,-0.012008247,-2.5257467e-33,0.051678725,-0.088684104,0.06435068,-0.031018022,-0.020625971,0.015998801,0.0038331791,-0.06692321,-0.05653375,0.014331787,0.10461742,-0.0292001,0.0042889626,0.023657084,-0.024530077,-0.03411529,0.0027689303,0.089589454,-0.02971966,0.03704102,0.028996402,0.05891329,0.009893738,0.041343402,0.014426094,0.008880878,0.0019268488,0.050422657,0.03256979,0.02201978,0.006996126,0.047662474,-0.05439062,-0.08172038,-0.0313856,0.003813279,-0.0169551,-0.020477552,0.095894866,0.07276424,-0.029350784,0.06943709,0.021579068,0.017065298,0.051755078,0.031290088,-0.1330175,-0.0160115,-0.06880707,0.027725868,0.09626495,0.056565173,0.0012939114,0.055280644,-0.03220215,0.024384044,-0.05726999,0.026354183,-0.014914047,-0.066057704,-0.06944218,-0.034288097,-0.0015496071,0.046239134,0.021931041,0.053174436,-0.046893872,0.07344485,0.071951546,-0.016584571,-0.04800669,-0.013964005,0.013595531,0.036080275,0.016623426,0.018743636,-0.0005924632,-0.017858857,0.07741752,-0.009237292,-0.017961167,0.027004324,-0.015768532,-0.086764276,0.028078897,-0.03496173,-0.045007106,0.13044362,0.058980647,-0.016628077,-0.004096145,0.030761585,0.015734585,0.10078066,0.06511974,-2.9068802e-08,-0.062661976,-0.053737625,0.009758444,0.02883416,0.015442837,-0.0128160715,0.019018706,0.011777109,0.011074353,-0.052725736,0.060616203,0.06643233,-0.011985095,-0.008997815,0.0170409,0.06518942,0.01478405,0.005653058,0.040608626,0.037648816,0.00892664,-0.024257148,-0.051299315,0.113192104,0.025841946,-0.08039806,0.011585013,-0.0018512326,0.014796754,-0.0143618025,0.03312385,0.050142206,-0.05953609,-0.012581843,0.013590724,0.048718408,-0.054354325,-0.045575254,-0.0126753785,0.013682782,0.009087375,-0.09409542,-0.07383014,-0.04224103,-0.031866096,0.010468658,0.025315452,0.07489908,-0.07321276,-0.026820462,-0.0028174205,-0.019765131,0.018444976,-0.10823814,-0.11873958,-0.054127377,0.051831458,-0.07269253,-0.07328293,-0.08424678,0.07523761,-0.01852247,0.18288511,-0.0005810812 +1.14.14.183,A cytochrome P-450 (heme-thiolate) protein from the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis. ,384,1.0,-0.051292643,0.014776467,-0.08993492,-0.055253252,0.025816984,0.040897425,0.028788136,0.02900827,-0.0015585816,0.020316448,0.05840905,-0.019542357,-0.073391296,-0.027577905,0.017951593,0.013181879,-0.056589264,0.0108172605,-0.015321153,-0.061305363,0.083558634,0.061421614,0.012195462,0.015371456,0.011056406,-0.06309804,-0.039018817,0.03447752,0.0006727001,-0.11912653,-0.02814527,-0.0047507808,-0.047474284,0.026153678,0.022482999,0.06894892,-0.02885518,-0.04666731,0.020959238,-0.05757821,0.088321164,-0.008319307,-0.098934256,0.012784696,-0.07808719,-0.019499093,0.017055046,0.018551499,0.023734543,-0.020819724,-0.025951857,-0.077872284,0.0055066324,0.03494626,0.007724843,-0.009580949,0.00457651,0.011224485,-0.010325719,-0.06777636,-0.050645392,0.036735788,-0.01360006,0.011135127,-0.025164703,-0.007872253,-0.03234692,-0.036418468,-0.028745338,-0.07009017,-0.042295463,-0.059166826,-0.0054574283,0.055603117,-0.11910464,0.11136095,-0.0044755978,0.05781382,-0.015225858,-0.05850434,0.01754922,0.081779204,-0.0055297455,0.13567747,0.048044425,-0.04539995,-0.01971396,0.06120775,0.03833669,0.010551269,0.028655164,0.03582281,0.003364031,0.013351317,-0.110638894,0.05587719,0.06504511,-0.073333055,-0.0068885,-0.014930707,0.05272961,0.08421795,0.042729206,-0.11291745,-0.11513083,0.035934467,-0.11538558,0.053066082,0.027252309,-0.05777319,0.016758496,0.00022275042,-0.0010074077,0.014282409,-0.009435595,0.06973764,-0.018733094,-0.058741156,-0.02135447,-0.07325777,-0.04799795,-0.021763785,-0.0050742,-0.004497115,-0.045233913,-0.0033938906,-0.032053564,1.8085882e-33,0.074573025,0.0420952,-0.018103924,-0.034501154,0.07938968,-0.005532353,-0.050952483,0.05571139,-0.0783379,0.005108076,-0.12845205,-0.09949351,-0.0019024801,-0.09305424,-0.01233172,0.041177493,-0.06849237,0.04249237,0.03541815,0.024721965,-0.050058234,0.038080867,-0.008605953,-0.09086218,-0.018872617,0.11614529,-0.060625017,-0.03525059,0.022861669,0.02345172,0.008594188,-0.027283562,-0.0038956355,-0.012521415,0.032484632,0.010584174,0.019393716,-0.045965582,-0.05852385,-0.010413763,0.02320009,0.013024385,0.07167839,-0.042166848,0.033905365,-0.06881202,-0.07285736,0.04452192,0.0072366637,0.02444608,0.031503525,-0.040941454,0.10487633,0.022760805,-0.06936975,0.016310368,0.026553024,0.05956425,0.015964152,0.093528755,0.09132476,0.02529754,-0.060514614,0.017231226,0.0053998344,0.059709422,-0.08793244,-0.026809739,-0.036534116,0.115877606,-0.056811117,-0.04703914,0.01038685,-0.035456643,0.08464305,-0.026348993,0.0010505976,0.012685802,0.012104696,0.12582934,0.018881802,0.01800503,-0.0812596,-0.040625796,0.0033298049,-0.037915297,0.060218878,0.066985615,-0.020175328,0.016684303,0.048018567,-0.047492288,0.016432133,0.018186344,-0.012008247,-2.5257467e-33,0.051678725,-0.088684104,0.06435068,-0.031018022,-0.020625971,0.015998801,0.0038331791,-0.06692321,-0.05653375,0.014331787,0.10461742,-0.0292001,0.0042889626,0.023657084,-0.024530077,-0.03411529,0.0027689303,0.089589454,-0.02971966,0.03704102,0.028996402,0.05891329,0.009893738,0.041343402,0.014426094,0.008880878,0.0019268488,0.050422657,0.03256979,0.02201978,0.006996126,0.047662474,-0.05439062,-0.08172038,-0.0313856,0.003813279,-0.0169551,-0.020477552,0.095894866,0.07276424,-0.029350784,0.06943709,0.021579068,0.017065298,0.051755078,0.031290088,-0.1330175,-0.0160115,-0.06880707,0.027725868,0.09626495,0.056565173,0.0012939114,0.055280644,-0.03220215,0.024384044,-0.05726999,0.026354183,-0.014914047,-0.066057704,-0.06944218,-0.034288097,-0.0015496071,0.046239134,0.021931041,0.053174436,-0.046893872,0.07344485,0.071951546,-0.016584571,-0.04800669,-0.013964005,0.013595531,0.036080275,0.016623426,0.018743636,-0.0005924632,-0.017858857,0.07741752,-0.009237292,-0.017961167,0.027004324,-0.015768532,-0.086764276,0.028078897,-0.03496173,-0.045007106,0.13044362,0.058980647,-0.016628077,-0.004096145,0.030761585,0.015734585,0.10078066,0.06511974,-2.9068802e-08,-0.062661976,-0.053737625,0.009758444,0.02883416,0.015442837,-0.0128160715,0.019018706,0.011777109,0.011074353,-0.052725736,0.060616203,0.06643233,-0.011985095,-0.008997815,0.0170409,0.06518942,0.01478405,0.005653058,0.040608626,0.037648816,0.00892664,-0.024257148,-0.051299315,0.113192104,0.025841946,-0.08039806,0.011585013,-0.0018512326,0.014796754,-0.0143618025,0.03312385,0.050142206,-0.05953609,-0.012581843,0.013590724,0.048718408,-0.054354325,-0.045575254,-0.0126753785,0.013682782,0.009087375,-0.09409542,-0.07383014,-0.04224103,-0.031866096,0.010468658,0.025315452,0.07489908,-0.07321276,-0.026820462,-0.0028174205,-0.019765131,0.018444976,-0.10823814,-0.11873958,-0.054127377,0.051831458,-0.07269253,-0.07328293,-0.08424678,0.07523761,-0.01852247,0.18288511,-0.0005810812 +1.21.3.10,"Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine.",384,1.0,0.027479379,-0.009541292,-0.10310555,0.038725466,0.12596957,0.039115384,-0.062007908,0.015878802,0.01080334,-0.06834027,0.036648884,-0.0646304,-0.060638897,0.0074375467,-0.017176587,0.025054652,-0.052834462,0.009939879,-0.03283785,-0.059609227,0.050357305,0.014563141,0.00905049,-0.038977794,-0.0044430792,-0.04143743,0.035927344,-0.033209596,-0.031361714,-0.12207222,-0.008330372,-0.073193096,0.04526133,-0.04495708,0.015781779,0.08300617,-0.034877807,-0.012443237,0.020190775,0.01888417,-0.032002248,-0.067723855,-0.01793445,-0.025667995,-0.047573667,-0.07123808,0.006906636,-0.013010427,0.04861554,0.031160459,-0.035159595,-0.01791386,-0.014783937,0.00022211045,0.031859882,0.038076278,-0.0570945,-0.00805507,-0.048841856,0.024092752,0.08795314,-0.0016485254,-0.0069870157,0.005948994,0.0163909,-0.078177124,0.07681953,-0.07834577,-0.022125462,-0.063033044,-0.045993306,-0.067947336,0.010045663,0.038002465,0.041961487,0.025613945,0.01137273,-0.037269514,0.08353066,0.026434446,-0.025544655,0.006113603,0.029352162,0.03432195,0.06603671,0.03907806,-0.052239686,0.032515764,-0.04420868,0.07708311,0.07554369,-0.006599538,-0.0067774807,0.0038281968,0.05560873,0.078587115,0.014578725,0.06286317,0.042101324,-0.03395607,-0.019808643,0.08246572,-0.045408875,-0.031684827,-0.018040732,0.0058099274,-0.0047080764,0.08007429,0.018336572,-0.028669486,0.08759154,-0.02047148,0.03919853,-0.046169356,0.03326607,0.08397333,0.076414645,-0.049274907,-0.008714694,0.025505695,0.060346518,0.013745324,0.0029421286,0.06891272,-0.015226284,0.004307006,-0.102636315,2.0865572e-33,0.10316865,0.10679841,-0.05535756,0.015582777,-0.042501472,0.08215591,-0.061126404,0.044207733,-0.037392378,-0.0763976,-0.09978271,-0.057148714,0.044093624,0.036117923,-0.04339596,-0.054303885,0.0520869,-0.06228001,0.08900799,-0.023823671,0.022380184,0.011205947,-0.020582125,0.006608444,0.026708111,0.08703696,0.011561733,0.007192369,0.031989947,0.0045305933,-0.0072254706,-0.094141625,-0.09853744,0.074134834,0.09192733,-0.004386135,0.0043415157,0.019384684,-0.028204098,0.004415523,0.030959409,0.096871205,0.0032356314,-0.07737298,0.030694062,-0.09168071,-0.022774892,0.0965309,0.049490474,0.043591376,0.026064169,-0.011839292,0.091058806,-0.034673173,-0.03141968,0.011047223,-0.02824517,-0.008296935,0.055874016,0.079045676,-0.012954144,0.057668768,0.0072436603,0.084800154,0.05655913,-0.00024014334,-0.06172381,-0.040825274,-0.044924226,0.037567776,-0.045335267,0.0005443541,0.059106734,-0.011314294,0.033084515,-0.07964178,-0.14219563,-0.018228982,0.025634706,0.015661748,0.005848774,-0.03452148,-0.011257644,-0.03049814,-0.059365638,-0.010567608,-0.027577424,-0.0367001,0.02501936,0.013828586,-0.013393999,-0.07040568,-0.053831197,-0.0050914325,0.064368434,-4.0915245e-33,0.067642234,-0.10937831,0.04119543,-0.085340634,-0.039816063,0.071444646,0.021898886,-0.07556213,0.0084772315,0.031071384,0.07003567,-0.022830954,0.03536134,-0.0976606,-0.017012915,-0.019157467,-0.06152815,0.090636685,0.050615434,0.023069752,-0.057839263,0.09569135,-0.003209158,0.060258873,0.10915585,0.006737375,-0.042275093,0.02662614,0.03249576,0.0433436,-0.06191035,-0.01708541,-0.036324874,-0.08474128,-0.051081065,0.064607516,-0.077963576,0.00090607454,0.04366097,0.009409259,0.021049997,0.01904709,-0.0085246805,0.091181725,0.042232625,0.09060173,-0.055927876,0.10062917,0.0026470637,-0.066536695,0.011102037,-0.03101409,-0.04244918,0.021698745,0.040050276,0.015264466,0.024963347,0.0015018496,-0.028047567,0.0040014656,-0.0458705,-0.03279974,-0.007182809,-0.009592602,0.055573687,0.010515039,-0.09216757,0.057938103,0.03828065,0.029143402,0.08645002,0.0055045295,0.039677948,0.022645576,-0.059063047,-0.061981145,-0.0535769,-0.025368487,0.027395101,0.013228965,0.016443828,-0.02023304,0.04607197,-0.06583422,0.0045708786,-0.09442261,0.039248597,0.070432626,-0.06280552,-0.0041644853,-0.028398018,-0.014860454,-0.101721704,0.07907356,0.018475927,-4.1955577e-08,0.028425274,-0.05547587,0.029363373,-0.13746543,-0.016278591,-0.004546785,0.04491777,0.0027601584,0.027107634,-0.011190542,-0.064554475,0.114161566,0.03471057,-0.0028368572,0.04341791,-0.0011208437,0.049031775,0.11303772,-0.016143242,0.002314312,-0.046803568,-0.054189976,-0.11721409,-0.004115617,0.013915821,-0.053309802,0.0050154193,0.007366715,0.07370982,-0.037901927,-0.0024264771,-0.010040897,0.028644051,-0.03513749,-0.10730505,0.023751052,-0.05905678,-0.07708699,-0.011326531,-0.02869914,-0.008613218,0.0021981706,-0.06256527,-0.014053167,-0.057282735,-0.06182017,-0.00067044783,-0.0043977825,-0.03452568,-0.014297877,0.027310316,-0.081029326,0.0064335023,-0.058986124,-0.05052029,0.037268408,0.024423674,-0.046367686,0.04402609,-0.06259534,0.002730014,-0.0026181561,0.16906269,-0.038827866 +2.1.1.382,"This entry stands for a family of enzymes that have been characterized from acetogenic bacteria and archaeal species. Different members of this family have different substrate specificity. In the methanogenic archaeon Methermicoccus shengliensis the enzyme participates in methanogenesis from methoxylated aromatic compounds, while in acetogenic bacteria and in non-methanogenic archaea it participates in methoxydotrophic growth. Most of the enzymes have a wide specificity and were shown to act on a large number of methoxylated aromatic compounds, carrying a methoxy group at positions 2, 3 or 4 of the aromatic ring. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state; during methylation the cobalt is oxidized to the Co(III) state.",384,1.0,-0.034678794,-0.055871498,-0.15552932,-0.011413847,0.09432633,-0.011087091,-0.06587141,0.01780864,0.03371949,-0.06935783,-0.03188341,-0.09595866,-0.058702946,-0.0448341,-0.08132095,0.053199634,-0.053295717,-0.047184326,0.028361524,0.028705219,0.06895231,0.028402075,-0.07761705,-0.031996407,-0.04510132,-7.110501e-05,0.018559398,-0.01001969,-0.015989523,0.016597342,0.01757106,0.009608627,0.043543916,0.008803273,0.034934416,0.09527277,0.014717409,-0.054107983,0.062050745,0.040205777,0.04049005,0.050466396,0.06890844,-0.054446,-0.008467636,-0.012214088,0.0073999693,0.0072478657,-0.010427053,-0.0804049,-0.09245703,-0.069430225,-0.07889279,0.05644103,-0.0029561645,0.09646571,-0.057688646,-0.057695065,0.02121183,-0.047378834,0.059342902,-0.052150793,0.045316268,-0.012423797,0.03705984,-0.038600042,0.0226776,-0.09126383,0.07234617,-0.046237852,-0.05097892,0.016630398,-0.06848182,-0.02364915,-0.031224353,0.057354156,-0.01638617,-0.076397754,0.09304703,-0.11826547,-0.02033188,0.09462536,0.040625997,-0.034859955,0.050991986,0.016748758,0.014764905,0.0051076426,-0.0043795775,0.02105194,0.019269146,-0.03871377,-0.005555901,-0.021862064,-0.109044135,-0.0060321954,0.1984359,0.08036804,-0.0052495003,0.0020521048,0.002893033,0.019455682,-0.0366975,-0.045668267,-0.09886148,-0.07457168,0.105858356,0.12663458,0.019331178,0.10011666,-0.006707651,0.018875133,0.018565828,-0.043029316,-0.01687855,0.11530667,0.048428543,-0.07019708,-0.033710837,0.047218822,0.0040450934,-0.0494036,0.04849005,-0.053047597,-0.006562255,0.039125588,-0.035673153,4.2779384e-33,0.07267176,0.017385317,-0.02136969,0.008597615,0.026878897,-0.023878152,-0.11548825,-0.024766305,0.039951455,-0.04738473,-0.04460113,0.017213343,0.022266371,-0.003797577,-0.03900433,0.0098376945,-0.052628133,-0.022177832,0.003177659,0.011274371,-0.012369663,0.05960504,-0.04221065,0.037924327,-0.0043988647,-0.042439103,-0.043947622,-0.0028068097,-0.024293017,0.02444691,0.015943954,-0.0641833,-0.1094306,-0.009339891,0.106595226,0.041494243,-0.027820459,-0.02642984,-0.037835795,-0.023319539,0.07137919,-0.0064852023,-0.016785419,-0.015457111,0.020629808,-0.043298434,-0.056007367,0.09405693,0.004095546,-0.004413844,-0.036622047,0.011734234,0.0999915,-0.0071770595,-0.07759916,-0.0064707063,-0.012586763,-0.04100065,0.051794518,0.023831133,-0.023552122,0.020378817,0.035776757,0.120256305,-0.03743479,-0.008962751,-0.05058549,0.03526472,0.104650274,0.07184657,0.0070713945,-0.06383426,0.02319942,0.11504439,-0.01569691,-0.018442605,0.019421564,-0.020119127,0.046551425,0.005849855,0.03752585,0.017574232,0.041459657,-0.060013723,-0.05194731,0.019668525,-0.033814564,-0.03431058,-0.009033604,0.0025638503,0.013217605,-0.008808281,-0.0007398723,0.012106218,-0.04205025,-6.1285265e-33,0.070421144,-0.07225165,0.046385452,-0.1439562,-0.085557185,0.113854945,-0.04360051,-0.06301836,0.012876652,-0.093330555,0.12847349,0.027837906,0.0071019456,-0.04964187,0.040398054,-0.052157205,-0.020375311,0.09637144,0.03802035,0.012755051,0.069460444,-0.010178342,-0.07772776,-0.030661741,0.0050876755,0.014959276,-0.06447158,0.012714601,0.00051902566,0.041844364,0.002213338,0.022800324,-0.011825695,-0.00598612,-0.071551844,-0.007515158,-0.030655844,-0.020977093,-0.0008647524,-0.006072288,0.033756062,-0.019323757,-0.0035475201,0.06457391,0.099254,0.01104106,-0.098710805,-0.007248721,0.010262344,0.010675101,0.0155214835,-0.060642637,-0.066680975,-0.018643765,0.04455702,0.11767251,0.0012891099,0.050983503,0.022370864,-0.039815694,-0.07293554,-0.012275421,0.012368687,0.0049901484,0.04684724,0.032427512,-0.028718045,0.040829048,0.048787627,-0.01937253,-0.0053481106,0.083665706,0.0020454014,-0.011236793,-0.05100387,-0.08220086,-0.022089029,0.0047135656,-0.03200895,-0.038403194,-0.0511503,0.007775036,0.08940144,-0.033149883,-0.04913846,-0.038980506,0.0917365,-0.015841579,-0.062340092,0.007798516,-0.039979406,-0.04355243,-0.08649238,-0.021346277,0.0035520203,-4.5170342e-08,0.03990842,0.036255646,0.06746815,-0.028142747,-0.012168505,0.027761495,0.010943561,-0.042217493,0.06484229,0.0057698847,0.018753972,0.04659453,0.03710496,-0.0031116065,-0.016199326,0.04632934,-0.086875744,-0.011199656,-0.03394821,0.04281588,-0.010806182,-0.026013833,0.050378136,0.060475346,0.046366397,-0.06805565,0.04182957,0.09684032,-0.036796283,-0.03543677,-0.03773561,0.029202573,0.06402424,0.023965577,-0.076492906,-0.0028505218,-0.056524787,-0.02851614,-0.056354735,-0.0071479105,0.041413497,-0.030181061,-0.064684466,0.019449174,0.06785532,-0.004616274,-0.048125733,0.10782488,-0.009030451,0.017603287,-0.0015699089,-0.013024465,0.06297524,-0.054723043,-0.051377762,0.007700658,-0.004153881,-0.0047601135,-0.011110312,-0.009886625,0.06710662,0.01832539,0.10192875,-0.022729026 +2.1.1.384,"The enzyme has been characterized from several archaeal species. In the methanogenic archaeon Methermicoccus shengliensis the enzyme participates in methanogenesis from methoxylated aromatic compounds, while in the non-methanogenic Archaeoglobus fulgidus it participates in methoxydotrophic growth. The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (MtoC) to tetrahydromethanopterin or tetrahydrosarcinapterin. cf. EC 2.1.1.385, [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase.",384,0.99999994,0.0008246813,-0.012507185,-0.17294927,-0.034710143,0.07480043,0.005853378,-0.10391987,0.002624504,0.055164274,-0.055427983,-0.0008203673,-0.14601043,-0.04944381,-0.049235523,-0.120522395,0.027764015,-0.0730621,-0.029030416,0.051807046,-0.0052037765,0.063868284,0.047424227,-0.062053695,-0.01601806,-0.04458237,-0.025791094,-0.04557693,-0.036184352,-0.0026238242,0.04910751,0.009468879,0.024625251,-0.008106093,0.0031054928,0.0545539,0.12394944,-0.007512406,-0.061186608,0.06388726,0.0540524,0.046808425,0.02785171,0.06385246,-0.06536533,-0.049577784,0.009289078,0.025851723,0.014440897,0.0042006425,-0.03444019,-0.07219197,-0.079973936,-0.068076685,0.049800333,0.02453425,0.078176014,0.014239111,-0.05213916,0.013196272,-0.016546393,0.030606423,-0.007638607,0.0504757,-0.0073399763,0.023693746,-0.023240196,-0.008893439,-0.08212842,0.09384307,-0.06626447,-0.081748106,0.057412207,-0.023256738,-0.021922208,-0.03679869,0.06918044,-0.026585788,-0.044912342,0.07868212,-0.08700212,-0.008044338,0.08079318,0.006520055,-0.03989072,0.06570146,-0.03272618,0.009586168,0.043883916,0.01704534,0.031987064,0.07008278,0.0010951699,0.0080056265,-0.035851903,-0.08272997,0.0007666126,0.10744785,0.06796017,-0.032789193,-0.02376625,-0.029379074,0.033612672,-0.035428915,-0.06411286,-0.10016099,-0.04971442,0.03310778,0.14477403,0.059266057,0.0826844,-0.020240722,0.011981958,0.052611206,-0.00011516858,-0.002366289,0.11428294,0.007456863,-0.10470792,-0.039398212,0.0020850734,0.017622458,-0.06453107,0.040481143,-0.0061746878,0.01180352,0.052532107,-0.0741924,6.193998e-33,0.08872604,0.056385044,0.000674329,0.005427209,0.025659274,-0.052388284,-0.08214748,0.031135978,0.0171297,-0.042994473,-0.07816212,0.00108486,0.021939874,0.002416626,-0.026285669,-0.011808426,-0.025986953,-0.028014991,0.019443382,0.0065095183,-0.0177551,0.053860974,-0.030353127,-0.0018522975,0.0282539,0.020171428,-0.06968986,-0.0075144237,0.010843275,0.021709362,0.0038107801,-0.12919866,-0.14006144,-0.011496574,0.112834424,-0.015482059,-0.02157637,-0.038727,-0.074745595,0.004431827,0.055459116,-0.015109523,-0.0019292275,-0.023581233,0.041687593,-0.02632765,-0.029935904,0.060129628,0.030273518,-0.010530082,0.008726423,0.019469295,0.06286489,-0.019929288,-0.11572032,-0.03894761,-0.033768423,-0.051996686,0.048371144,0.043291558,-0.040347066,0.00141898,0.033504408,0.09216223,-0.023601051,-0.03975526,-0.014158403,-0.0012594482,0.08184489,0.05320622,0.01762329,-0.046817224,0.025854157,0.06906997,0.01837858,-0.02333273,0.0015622847,-0.06436297,0.028332006,-0.0044952002,0.05015012,-0.0069280155,0.048040174,-0.054906704,-0.0494652,0.047928806,-0.03519099,-0.0014617088,-0.00321757,0.02186392,-0.009747242,-0.026589824,-0.022309713,0.025086846,-0.026479384,-6.751899e-33,0.08550869,-0.08846146,0.034707673,-0.16739602,-0.10217324,0.10967054,-0.025708912,-0.04600681,0.027400447,-0.08619365,0.13448736,-0.01092706,0.054543607,-0.05431796,0.047827005,-0.046362124,0.0019675388,0.10683942,0.020183228,0.0044902223,0.08782377,-0.012464768,-0.06304065,-0.023453552,0.016314287,0.026090333,-0.03816082,0.030503647,-0.0016158359,0.038329378,0.0025518886,0.007184344,-0.030129977,-0.019927934,-0.079801284,0.0034531564,-0.05341878,-0.036381535,0.041739702,0.035094045,0.06852039,0.03158311,0.0224199,0.014402048,0.064179264,0.024669733,-0.10697855,-0.0023824072,0.07152466,0.0593818,0.028609693,-0.033994555,-0.057972416,-0.037369706,0.036720924,0.100570284,0.011450932,0.014564983,-0.014455627,-0.055819314,-0.055348717,-0.02854463,0.015944105,-0.015292456,0.062340844,0.076976046,0.012993395,0.07582459,0.059947405,-0.000712723,0.054552842,0.07404883,0.0023346182,0.014128851,-0.012621469,-0.048540466,-0.042857416,0.045127816,-0.0058689048,-0.039243545,-0.020170774,-0.007813261,0.12883434,-0.060323875,-0.039060373,-0.043394238,0.07728326,0.007911777,-0.028450008,-0.0062810075,-0.030400421,-0.05614141,-0.072067894,-0.022769807,0.03381225,-4.475026e-08,0.01096418,0.016698616,0.035979092,-0.057493765,0.016010784,0.043048188,0.02941593,-0.050647747,0.008540008,0.0048693973,0.022966402,0.0006047492,0.036874212,0.016387576,-0.032887902,0.042022552,-0.08708533,-0.018454868,-0.008524797,0.030372541,-0.030044938,-0.029764319,0.003710021,0.05888994,0.017077558,-0.06690308,0.03453525,0.10490374,0.0006804731,-0.049731113,-0.037609316,0.04255319,0.0131424675,0.015648654,-0.05467659,0.03569118,-0.051593877,-0.009238219,-0.070854515,0.011175431,0.034615636,0.013298169,-0.041069563,-0.00084209716,0.04502393,-0.014711762,-0.00838562,0.10355334,-0.0065065273,0.024518462,0.05153898,-0.005499734,0.041785732,-0.039988235,-0.055496145,-0.058663927,-0.020774122,-0.02754916,-0.022507805,-0.042688098,0.06463199,-0.018186573,0.12479154,-0.04084862 +2.1.1.385,"The enzyme, found in acetogenic bacteria, participates in a pathway for the degradation of methoxylated aromatic compounds (methoxydotrophic growth). The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (MtvC) to tetrahydrofolate. cf. EC 2.1.1.384, [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydromethanopterin methyltransferase.",384,1.0,-0.0017549156,0.00030358197,-0.20622376,-0.025590485,0.11434677,0.034224536,-0.059480786,0.021702206,0.017593568,-0.050800923,0.030392064,-0.08865526,-0.05768101,-0.038977284,-0.08708628,0.025226578,-0.09303518,-0.040902138,0.033624947,-0.0589678,-0.013634786,0.029188378,-0.08987861,-0.0534126,-0.022613715,0.043434326,-0.027564712,-0.0241821,0.0044395626,-0.005048512,0.033889472,0.06558411,-0.0315086,-0.029447183,0.05608024,0.07709923,-0.0034835557,-0.09109383,0.087315656,0.047025606,0.04222503,0.038024228,-0.0045654196,-0.034348328,-0.043827478,-0.011615493,0.009235335,0.03572654,0.0067574168,-0.05895075,-0.08266392,-0.04845396,-0.039940346,0.03918869,0.010464057,0.049543977,0.018949661,-0.068722144,-0.011610241,0.01787331,0.050665863,-0.06535939,0.041048665,0.01891583,0.043637995,-0.04535616,0.03826499,-0.11536611,0.011978029,-0.035610255,-0.096118726,-0.010631098,-0.046668682,0.042690776,-0.0028143215,0.037967715,-0.009873846,-0.062306058,0.082188666,-0.05803528,0.00063103606,0.07497619,0.013505189,-0.02596478,0.04718906,-0.0131572215,-0.015914656,-0.03570417,0.049118012,0.10794619,0.024053216,-0.01912608,0.034167074,-0.024027051,-0.112079486,0.016980302,0.13539177,0.051689304,0.024315016,-0.016666705,-0.048368536,0.046587136,-0.05762249,-0.030236205,-0.08639428,-0.012009781,0.0917262,0.14971976,0.04791818,0.07902851,-0.055592928,0.021932948,0.027942453,-0.06723206,-0.023830174,0.108377665,0.053374294,-0.04408629,-0.015813068,0.0020337894,0.04023265,-0.056628224,0.0047587077,-0.025519496,0.018361418,0.055896483,-0.06082015,2.5943928e-33,0.078150205,0.06944758,-0.021122377,0.032965753,0.025542835,-0.023519823,-0.105343275,-0.002447067,0.0659153,-0.084822305,-0.07248617,-0.04709043,-0.0014553162,0.0052519473,-0.013207477,0.002534981,-0.052243195,-0.016198972,0.007294325,0.009772112,-0.009340785,0.07293685,-0.03154704,0.009416108,0.034549464,0.051595714,-0.06830321,0.029631054,0.010733465,0.028661536,-0.004791913,-0.071938865,-0.12115172,-0.026078995,0.115341544,-0.009992948,-0.050395623,-0.0036408063,-0.013018575,0.046204764,0.08801612,0.0135198375,-0.02986651,0.015383119,0.006477415,-0.06998142,-0.017434899,0.059525196,0.012346006,-0.018770367,0.006975927,-0.0075370595,0.07408309,-0.04004527,-0.07755878,0.0121112615,-0.045971382,-0.06550788,0.029672854,0.00089311326,-0.011898223,0.016061967,0.01454634,0.08751218,-0.0099595655,-0.04625824,-0.015061238,-0.039546847,0.087831706,0.02167421,-0.022990217,-0.020758709,0.075322635,0.05177117,0.021260753,-0.04521394,-0.022574542,-0.03690979,0.07306383,-0.02245598,0.016795538,0.03271334,0.09864843,-0.08049867,-0.008495648,0.00916192,-0.05366899,-0.05162509,-0.012068078,-0.017845012,0.022020686,-0.025116399,-0.03317785,-0.031620882,-0.010837157,-4.2990176e-33,0.08142227,-0.09324056,0.048192553,-0.13445526,-0.10002493,0.08845995,-0.03098937,-0.043418597,-0.0029540786,-0.010230783,0.096679226,0.004089794,0.009457412,-0.0698193,0.07330733,-0.078620225,0.0009156592,0.06789356,-0.015948411,-0.019455342,0.06062421,-0.02050561,-0.018860906,-0.018115865,0.0019355316,0.015000622,-0.074411064,0.0155866,0.04390721,0.032910213,0.009472982,-0.019207548,-0.021577498,-0.0024004118,-0.014586869,0.044007566,-0.033243272,0.020340223,-0.013498106,-0.00336091,0.049844872,-0.02931943,-0.0066646277,0.036734764,0.055496026,0.047144573,-0.08588307,-0.0051787407,0.03817608,0.05102896,0.07082459,0.0037776695,-0.08950115,0.011162089,0.046905372,0.09522064,0.05293631,-0.0041376706,0.01752419,-0.021347275,-0.055130653,-0.016553251,-0.012109961,0.044343967,0.074589275,0.053673193,0.030156177,0.08613878,0.061290573,-0.00096831965,0.030226288,0.10768293,-0.0034263514,-0.025364392,-0.030932445,-0.06847414,-0.083126664,0.020488594,-0.041630924,-0.022919687,-0.03652538,-0.020899778,0.04795282,-0.03953087,-0.021045925,-0.04358166,0.02968068,0.046672177,-0.05194599,0.020615581,-0.029644711,-0.059626307,-0.096232265,-0.0021258432,0.009004243,-4.3575007e-08,0.0012370546,-0.007804377,0.026270486,-0.055412266,0.03313751,0.06532048,-0.04045967,-0.050845873,0.08236936,0.0252648,-0.003670249,0.060733203,0.056128476,0.027960049,-0.03919443,0.027787844,-0.076834604,-0.0053344546,-0.0062538683,0.035663053,-0.05398521,-0.015194292,-0.020217894,0.07147138,0.05179018,-0.07318195,0.030291045,0.1356892,-0.00816556,-0.06316157,-0.036874913,0.04571703,0.02905229,0.04221353,-0.06986898,-0.024713121,-0.012743175,-0.029770285,-0.052404422,0.060125012,0.024320077,0.05837762,-0.10449592,0.0067665367,0.047948185,0.038084187,-0.0147011345,0.07967803,-0.04507999,-0.0017995229,0.023938827,-0.02353826,-0.0025404603,-0.016648116,-0.06837904,-0.04977298,-0.022514602,-0.015255845,-0.0023110313,-0.02648512,0.02541806,0.022245344,0.1382394,-0.028692959 +2.2.1.15,"The enzyme, characterized from the bacterium Clostridium sp. MSTE9, is involved in a D-sulfoquinovose degradation pathway. 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+2.4.1.389,"The enzyme, characterized from the bacterium Paenibacillus borealis, belongs to glycoside hydrolase family 94 (GH94).",384,1.0,-0.050241455,-0.024629949,-0.097814776,-0.05263778,0.023859706,-0.0028792978,-0.057904057,0.016444707,-0.028178837,-0.0812196,0.013247014,-0.038013343,-0.056875195,0.044407513,-0.10799152,-0.027641065,-0.045832746,-0.0969169,0.006827748,-0.0702436,0.057092268,0.12125928,0.011955151,0.0024314183,0.03247343,-0.04254493,0.05165413,-0.03616626,0.013133646,-0.018475244,0.0054575247,-0.069851376,0.029653106,0.030693699,0.03578118,0.07640385,-0.069429144,-0.008718762,0.05314132,0.0045428635,0.075216,-0.022633977,0.062084347,-0.054081887,-0.0450601,0.060041387,-0.009975426,-0.007798142,0.022972822,0.06599347,-0.053255342,-0.07101158,-0.050065953,0.038295545,0.06875544,-0.048821278,-0.030365419,-0.0069554937,-0.050999925,0.025968747,0.061570976,0.01663839,-0.0050414754,0.028753862,-0.080470674,0.0035303477,0.10574534,-0.084178515,-0.014452414,-0.0763471,-0.05707155,0.013068856,0.012872049,-0.017616343,-0.009970471,0.0493685,-0.016776478,0.029215962,0.053275045,-0.026148481,0.03812908,0.006451491,0.061991468,0.10655083,-0.062888674,-0.0043133902,0.02984636,-0.0018760399,0.06045895,-0.059395447,-0.025373539,-0.032241922,-0.009824187,-0.031434394,-0.02940952,0.04645861,0.0002915875,-0.063523345,0.029376535,-0.033634484,-0.015997251,0.03738237,0.0025856576,-0.07832781,-0.08756777,0.005638572,-0.0038817676,0.10148574,0.047625452,0.0009038439,-0.030102992,0.092529885,0.0204056,-0.011703759,-0.00668024,-0.045087453,0.024321038,-0.019737065,-0.056125958,-0.042777453,0.0152904205,0.019491311,0.06583834,0.021111067,-0.03436049,0.043555997,-0.11421797,2.8336559e-34,0.06336684,0.033952925,0.06516022,-0.06867261,0.002761148,-0.06697272,-0.10822765,0.027432105,-0.14885007,-0.0015627462,-0.03194588,-0.07378854,-0.037230853,0.076594144,0.030866789,0.044809204,0.006927994,0.04770176,0.05417628,0.016350236,-0.003658505,0.106842674,-0.010625793,-0.020854685,0.050132435,0.12705308,0.036201194,0.022754135,-0.005839258,-0.017889177,-0.0058517833,-0.042361785,-0.100707404,-0.046681967,0.031572673,0.0069786003,-0.09323871,-0.049385175,0.05776949,0.029165784,-0.014848655,0.033658814,0.042374406,-0.10004779,0.064428516,0.02747908,-0.012403468,0.011469599,0.027406808,0.05028178,-0.009510463,-0.030968757,0.09666755,0.06146917,-0.054426067,0.00034231032,0.030996518,0.05591591,0.017086072,0.030087957,0.054389033,0.10226693,-0.04087548,0.043480128,-7.997982e-05,-0.0013047607,0.005265454,0.006537073,0.00676615,0.08552144,0.010023569,-0.04611085,0.08015638,0.008224566,0.00781376,-0.082896955,0.062742315,0.012863617,-0.018167246,0.0064311135,-0.024761789,-0.009596791,-0.0016251858,-0.03282949,-0.10033512,0.004120469,-0.012820884,0.034541726,-0.045963712,0.06665573,-0.009190578,-0.04532667,-0.02583867,0.055287942,-0.091794044,-2.1375017e-33,0.14764258,-0.08447832,0.04727515,-0.061151866,0.00027143283,-0.024732405,0.05543829,-0.007056528,-0.016978407,-0.016120054,0.07352533,0.022794686,0.030554194,-0.016380724,0.032308348,0.02808009,0.0054103383,0.02977822,-0.0067092106,-0.018392392,0.05916338,0.08284594,-0.043726616,-0.0858212,0.07503477,-0.015483925,0.051073346,0.15229467,-0.05232553,-0.031753063,-0.08847815,0.037384108,-0.030729612,-0.09495214,-0.05289564,0.032437965,0.0017381888,-0.002481225,0.019701412,-0.052684855,0.03558558,0.098346375,0.039824616,0.09958817,0.06263589,0.06512146,-0.028329981,0.027263373,-0.0069385218,0.010489336,-0.026202505,0.0016119584,0.033807967,0.009427979,0.012417825,0.061565798,-0.0019372129,0.008458531,-0.06588877,-0.06815182,-0.048239596,-0.063676655,-0.00025433965,0.10907302,0.024460245,0.071124546,-0.039130844,-0.04658913,0.040998176,-0.018053504,-0.01192296,-0.05960292,0.0068825944,0.0527875,-0.009820165,0.022659598,-0.10902706,-0.0047545927,0.017934926,0.019953927,0.056005612,0.008076194,0.00091062253,-0.027342055,0.05808664,-0.103617094,0.053018942,0.09843953,0.02470652,-0.022701932,-0.04357435,0.031881202,-0.047781564,-0.034259398,0.00058684015,-2.7270993e-08,0.048360407,-0.07902594,0.036395803,-0.07686749,-0.01446716,-0.009816267,0.00888029,0.051953714,-0.055677984,-0.047580797,0.018138435,0.031002384,-0.029602492,-0.038922198,0.009174763,-0.03107292,-0.10910606,-0.023170352,-0.035978206,0.02637073,-0.087011404,-0.01821962,-0.099085934,0.09266463,-0.07347072,0.00241084,0.043558177,0.015258728,-0.045819867,-0.016615868,0.015934864,0.08183514,-0.013327989,-0.037558507,-0.056677766,-0.01924097,-0.009455298,0.02531174,0.043402236,0.024151102,0.036977023,-0.013843574,-0.029325226,0.009368018,-0.016423648,0.026839726,-0.05176094,0.0029101288,0.012019742,0.020247916,0.014612239,0.015619116,-0.060168613,-0.008931896,-0.06936545,-0.054558698,-0.015292766,-0.058479052,-0.041658916,-0.027372265,0.047260433,0.005316405,0.19218874,-0.0493416 +2.4.99.23,The enzyme catalyses a glycosylation step in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of many Gram-negative bacteria.,384,1.0,-0.030696394,-0.066915184,-0.07152663,0.038093306,-0.0310829,0.04182889,-0.093721904,0.050912704,0.013978056,0.029219672,0.053984083,-0.032863263,-0.02385425,0.022892982,-0.060597748,-0.03216464,-0.006121854,0.004350707,-0.032338563,0.013229496,0.08925655,0.018990874,-0.085988104,-0.034946512,0.04795366,0.0024314167,0.007630449,-0.07370316,-0.011736328,-0.048294436,-0.02603779,-0.10972337,0.05814211,-0.09168995,0.086743414,0.07715206,-0.0058931583,0.0024895845,0.11995385,-0.06347663,-0.033194672,0.009335565,-0.0023952648,-0.019859802,-0.007893569,-0.01373927,0.026279869,0.013011557,0.058239345,-0.027742362,-0.032408953,-0.026610343,-0.10079433,-0.0092142625,0.0827499,-0.036011133,-0.00034015777,-0.035216462,-0.032439563,0.04724813,0.028637383,-0.017978815,0.013512046,0.018105406,-0.02481303,-0.13554376,0.08797065,-0.018563902,-0.027427873,0.0068975845,-0.07077829,-0.042802993,-0.017090406,-0.0035961086,0.050346103,0.05672653,-0.030138373,-0.002044847,0.04065651,-0.0074651227,0.116853304,0.0024181965,0.04307984,0.14256532,0.011687772,-0.06578318,0.021818805,0.01617885,0.061910126,0.067745954,-0.0178019,-0.047211125,0.039193362,-0.033786625,-0.038713604,-0.033479214,-0.025936972,0.0019487109,0.06261174,-0.06362905,-0.019441064,-0.0627134,0.011246666,-0.087228864,-0.025892144,0.041596986,0.010534968,0.07897376,0.07483239,0.0010176164,0.011603202,0.00797473,0.033357084,-0.10119121,-0.049956456,0.043576494,0.082675256,-0.059298944,-0.057124324,-0.022517838,0.0011078945,-0.012088818,0.05219107,0.033205226,-0.06352939,0.064253844,0.005391002,8.174165e-34,0.021759829,0.012701918,0.028539883,-0.05244598,0.005104824,-0.051146306,-0.04706789,-0.030943085,-0.05802289,0.054431427,0.011402425,-0.105098896,-0.022492142,0.08026402,0.038879186,0.07630638,-0.03358405,-0.06693233,0.009130707,-0.00549199,-0.0018505485,0.017620621,0.042533435,-0.039262276,0.10094871,0.06647237,-0.034577265,-0.0041979533,-0.027559929,-0.018813146,0.053724013,-0.045390632,-0.09337385,0.0371339,0.11338422,0.0062445938,-0.012219403,-0.037738226,0.031949103,-0.035789393,-0.022871425,0.080967054,-0.06911913,-0.051428188,0.007893494,0.043415226,-0.03562506,0.026164658,0.051287673,0.033401575,0.045305286,-0.053598404,0.034207627,0.06035182,-0.04310358,0.05205888,0.02066169,0.0014535963,0.009560945,0.053959876,-0.019905824,0.033345178,-0.015076081,-0.055673767,0.007468708,0.014490057,-0.025332198,0.014240927,0.044611353,0.004534917,-0.0576184,-0.050255295,-0.027964018,0.029367713,-0.03519258,-0.03243361,-0.042798217,-0.0094979815,0.04672838,-0.043494094,0.0729288,0.040683124,0.0088808555,-0.053309232,-0.013883414,0.06907807,-0.09554035,-0.04600059,-0.008262553,0.09790759,-0.02858375,-0.025555465,-0.016088406,0.13116209,-0.13537665,-4.3239957e-33,0.048001897,-0.11190782,0.044595253,-0.08233369,-0.06407405,0.05119676,-0.024018941,0.03481611,0.0228011,0.056102637,0.032803915,-0.0015899471,0.06897312,0.093893096,0.014776916,-0.018035129,0.001020204,0.073597096,-0.02585352,-0.061908986,-0.010479723,-0.014028763,-0.0032263617,-0.017538331,0.09225197,0.032070003,-0.044246953,0.11533232,0.01790582,0.035511825,0.029214654,-0.018669892,-0.03324515,-0.055757362,-0.053356476,0.051934488,-0.067434914,0.0028988023,0.03821001,0.0071841776,0.0069750985,0.06444026,0.07438799,-0.0065670446,0.022234822,-0.014743648,-0.08637277,0.013098974,-0.018758055,-0.08808742,0.008863479,0.009562582,0.019499643,0.076198295,-0.048450503,0.04366256,0.059195016,0.0069573047,0.045420367,-0.10842435,-0.06770063,-0.057053633,0.040451244,-0.047128625,0.06634436,0.06265287,0.0146989,-0.033777125,-0.011910862,-0.07706398,-0.01032,0.010610995,-0.004043579,0.0151027,0.006141948,0.04113391,-0.114574604,-0.08893289,0.04690892,0.02605445,0.015561095,0.010363915,0.018538661,-0.026833687,0.03249419,-0.091411516,0.032767605,0.13448688,0.014746458,0.056836553,-0.03783291,0.0014222598,0.020362401,0.0038870561,0.07094184,-3.1229444e-08,0.00084166805,-0.04966856,0.035224754,-0.08026071,-0.056005113,0.022450825,-0.008252828,-0.004090617,0.038201164,0.0053566587,0.057152137,0.103375606,-0.015647326,-0.008798024,-0.07409035,0.05026512,-0.054812934,-0.016297296,0.028519051,-0.00222612,-0.104671665,-0.033932086,-0.11712505,0.04263027,-0.0035113078,-0.080171116,0.011290275,0.009463308,-0.051232453,-0.04794882,-0.0011431865,0.090878665,-0.016606752,-0.028122522,-0.08632428,-0.0005778273,-0.035446532,-0.052375462,0.02900887,-0.001476662,0.045934856,0.017234301,-0.050876465,-0.009670124,-0.005460617,0.051804714,0.021542054,0.044014998,-0.10384504,0.027184762,0.057014853,-0.046174143,-0.06474573,-0.02803502,-0.075248756,-0.068206444,-0.010670854,0.016760837,-0.0048009283,-0.0030905502,-0.034399882,-0.0031525441,0.1745705,-0.016995454 +2.4.99.24,The enzyme catalyses a glycosylation step in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of some Gram-negative bacteria.,384,1.0,-0.034132745,-0.06396282,-0.0709301,0.039490283,-0.030343192,0.0425145,-0.091378696,0.04989642,0.012203283,0.027638983,0.054115534,-0.03083573,-0.024136633,0.023494387,-0.061878044,-0.031344313,-0.0038439282,0.0052517983,-0.03194865,0.012956924,0.08708553,0.018690947,-0.08385256,-0.0307567,0.051091466,0.0026852912,0.006773585,-0.071317986,-0.010026267,-0.046816837,-0.02703283,-0.109775774,0.05658602,-0.09164439,0.08525439,0.07968109,-0.0032463262,0.0027602823,0.118193895,-0.06415041,-0.033509463,0.006526046,-0.0032434163,-0.018521352,-0.01146216,-0.01097095,0.026416345,0.012563323,0.049808588,-0.027945656,-0.032892592,-0.031621337,-0.09983333,-0.009534525,0.0812178,-0.032170653,-0.000330209,-0.034937654,-0.030659657,0.047389414,0.027684247,-0.018588632,0.012148929,0.02169311,-0.024261847,-0.13700682,0.08916512,-0.018733336,-0.02599509,0.0054533076,-0.0696294,-0.045934577,-0.016980125,-0.0051515074,0.051200476,0.05669539,-0.030160712,-0.0028351876,0.041000765,-0.0076859086,0.11612079,0.0042379256,0.041196607,0.1447324,0.010491133,-0.0630237,0.021468954,0.014507197,0.060141686,0.064402215,-0.015977444,-0.047830254,0.034119368,-0.032906413,-0.03935011,-0.035338756,-0.026042823,0.0015929808,0.06190035,-0.059254255,-0.019196149,-0.064470224,0.0070071537,-0.08598346,-0.024660332,0.043132305,0.010172972,0.07693526,0.076763704,0.0032637112,0.009327382,0.006922679,0.03227647,-0.10114767,-0.049824987,0.044071615,0.08549276,-0.059747458,-0.05519961,-0.02470144,0.00037785314,-0.013808921,0.052880943,0.032347005,-0.06302618,0.066001825,0.0071100895,7.0418205e-34,0.021709684,0.011990103,0.026443815,-0.056745697,0.0076776645,-0.051331468,-0.04525586,-0.030505074,-0.057317186,0.054720756,0.010175502,-0.10457622,-0.026399711,0.07691971,0.03802979,0.07614883,-0.034817856,-0.06780916,0.0092773065,-0.004260847,-0.0021703518,0.019348087,0.0404481,-0.03662288,0.10256056,0.06484547,-0.040426515,-0.0089549,-0.028357472,-0.017978776,0.0541567,-0.045285147,-0.09606069,0.03604683,0.11151284,0.0071944576,-0.013222019,-0.037769433,0.030260183,-0.034312032,-0.02190007,0.0794333,-0.07011803,-0.05108646,0.011887777,0.039248426,-0.035747018,0.028750157,0.052057806,0.033088323,0.048600093,-0.053286903,0.03789899,0.05580758,-0.043188225,0.055354733,0.022726737,-0.0013371886,0.0067445394,0.054661527,-0.016347127,0.03381416,-0.013213124,-0.060124155,0.0033338661,0.011155058,-0.02486026,0.012105164,0.042034086,0.0019785187,-0.058305673,-0.049967665,-0.027888699,0.03260933,-0.034434345,-0.0333742,-0.045728564,-0.0098844515,0.043892466,-0.046802685,0.07529024,0.040288832,0.012079366,-0.053971868,-0.019364402,0.0696485,-0.09643097,-0.043678124,-0.00854188,0.09682471,-0.032119554,-0.024997322,-0.016828572,0.13259436,-0.13100044,-4.3276633e-33,0.0490958,-0.114662014,0.043215357,-0.0807099,-0.06358485,0.051357597,-0.023624526,0.03635964,0.023178333,0.056328557,0.031510804,-0.0044159843,0.06610521,0.09504368,0.015932405,-0.016574932,-0.0014972814,0.07079904,-0.024847565,-0.061771475,-0.011782955,-0.011819833,-0.0038667948,-0.0170433,0.092319906,0.03200582,-0.04106737,0.118415065,0.016343411,0.034244258,0.027859153,-0.018027823,-0.033648588,-0.058363266,-0.054145925,0.052234944,-0.070761725,0.0009548039,0.035526212,0.007366859,0.010029726,0.06468113,0.07727449,-0.00016223591,0.023658564,-0.015143827,-0.08754216,0.013529581,-0.018258693,-0.08873211,0.0096885655,0.01213004,0.022902286,0.08047136,-0.04944343,0.044267215,0.056844823,0.006219019,0.04407409,-0.107143134,-0.06653621,-0.058436275,0.037427373,-0.045252554,0.06846127,0.063385576,0.011428719,-0.033942364,-0.008552231,-0.07689921,-0.007867037,0.011086049,-0.005164445,0.014184362,0.0052565094,0.04279829,-0.11553955,-0.08798644,0.044434786,0.023901979,0.0152749065,0.011345086,0.018755985,-0.026410948,0.03107613,-0.092278495,0.030200308,0.133866,0.013380513,0.05364933,-0.03731366,0.0033189605,0.019100005,0.0057750377,0.0715647,-3.125645e-08,0.0010211325,-0.048515502,0.032159682,-0.08015448,-0.057209235,0.02197207,-0.007148001,-0.0056900517,0.0381422,0.0056983046,0.0524557,0.10420501,-0.013418323,-0.008212266,-0.07493187,0.05174787,-0.051432576,-0.015575992,0.02575079,-0.004441862,-0.10779328,-0.031971205,-0.11542824,0.04240902,-0.007258332,-0.07803084,0.013379737,0.012967653,-0.04741369,-0.04624421,-0.0021241037,0.09761286,-0.014858599,-0.031280316,-0.087845534,0.0029935914,-0.033402104,-0.054003257,0.02633826,-0.0015980758,0.04674576,0.01974719,-0.050399695,-0.013621127,-0.005525174,0.050470106,0.028970242,0.04150214,-0.10187482,0.02786139,0.0585804,-0.046384186,-0.065919876,-0.027653737,-0.07557152,-0.07186766,-0.01094163,0.018360035,-0.00695025,-0.0043951226,-0.03558109,-0.00049416034,0.17961858,-0.01758166 +2.4.99.25,The enzyme catalyses a glycosylation step in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of some Gram-negative bacteria.,384,1.0,-0.034132745,-0.06396282,-0.0709301,0.039490283,-0.030343192,0.0425145,-0.091378696,0.04989642,0.012203283,0.027638983,0.054115534,-0.03083573,-0.024136633,0.023494387,-0.061878044,-0.031344313,-0.0038439282,0.0052517983,-0.03194865,0.012956924,0.08708553,0.018690947,-0.08385256,-0.0307567,0.051091466,0.0026852912,0.006773585,-0.071317986,-0.010026267,-0.046816837,-0.02703283,-0.109775774,0.05658602,-0.09164439,0.08525439,0.07968109,-0.0032463262,0.0027602823,0.118193895,-0.06415041,-0.033509463,0.006526046,-0.0032434163,-0.018521352,-0.01146216,-0.01097095,0.026416345,0.012563323,0.049808588,-0.027945656,-0.032892592,-0.031621337,-0.09983333,-0.009534525,0.0812178,-0.032170653,-0.000330209,-0.034937654,-0.030659657,0.047389414,0.027684247,-0.018588632,0.012148929,0.02169311,-0.024261847,-0.13700682,0.08916512,-0.018733336,-0.02599509,0.0054533076,-0.0696294,-0.045934577,-0.016980125,-0.0051515074,0.051200476,0.05669539,-0.030160712,-0.0028351876,0.041000765,-0.0076859086,0.11612079,0.0042379256,0.041196607,0.1447324,0.010491133,-0.0630237,0.021468954,0.014507197,0.060141686,0.064402215,-0.015977444,-0.047830254,0.034119368,-0.032906413,-0.03935011,-0.035338756,-0.026042823,0.0015929808,0.06190035,-0.059254255,-0.019196149,-0.064470224,0.0070071537,-0.08598346,-0.024660332,0.043132305,0.010172972,0.07693526,0.076763704,0.0032637112,0.009327382,0.006922679,0.03227647,-0.10114767,-0.049824987,0.044071615,0.08549276,-0.059747458,-0.05519961,-0.02470144,0.00037785314,-0.013808921,0.052880943,0.032347005,-0.06302618,0.066001825,0.0071100895,7.0418205e-34,0.021709684,0.011990103,0.026443815,-0.056745697,0.0076776645,-0.051331468,-0.04525586,-0.030505074,-0.057317186,0.054720756,0.010175502,-0.10457622,-0.026399711,0.07691971,0.03802979,0.07614883,-0.034817856,-0.06780916,0.0092773065,-0.004260847,-0.0021703518,0.019348087,0.0404481,-0.03662288,0.10256056,0.06484547,-0.040426515,-0.0089549,-0.028357472,-0.017978776,0.0541567,-0.045285147,-0.09606069,0.03604683,0.11151284,0.0071944576,-0.013222019,-0.037769433,0.030260183,-0.034312032,-0.02190007,0.0794333,-0.07011803,-0.05108646,0.011887777,0.039248426,-0.035747018,0.028750157,0.052057806,0.033088323,0.048600093,-0.053286903,0.03789899,0.05580758,-0.043188225,0.055354733,0.022726737,-0.0013371886,0.0067445394,0.054661527,-0.016347127,0.03381416,-0.013213124,-0.060124155,0.0033338661,0.011155058,-0.02486026,0.012105164,0.042034086,0.0019785187,-0.058305673,-0.049967665,-0.027888699,0.03260933,-0.034434345,-0.0333742,-0.045728564,-0.0098844515,0.043892466,-0.046802685,0.07529024,0.040288832,0.012079366,-0.053971868,-0.019364402,0.0696485,-0.09643097,-0.043678124,-0.00854188,0.09682471,-0.032119554,-0.024997322,-0.016828572,0.13259436,-0.13100044,-4.3276633e-33,0.0490958,-0.114662014,0.043215357,-0.0807099,-0.06358485,0.051357597,-0.023624526,0.03635964,0.023178333,0.056328557,0.031510804,-0.0044159843,0.06610521,0.09504368,0.015932405,-0.016574932,-0.0014972814,0.07079904,-0.024847565,-0.061771475,-0.011782955,-0.011819833,-0.0038667948,-0.0170433,0.092319906,0.03200582,-0.04106737,0.118415065,0.016343411,0.034244258,0.027859153,-0.018027823,-0.033648588,-0.058363266,-0.054145925,0.052234944,-0.070761725,0.0009548039,0.035526212,0.007366859,0.010029726,0.06468113,0.07727449,-0.00016223591,0.023658564,-0.015143827,-0.08754216,0.013529581,-0.018258693,-0.08873211,0.0096885655,0.01213004,0.022902286,0.08047136,-0.04944343,0.044267215,0.056844823,0.006219019,0.04407409,-0.107143134,-0.06653621,-0.058436275,0.037427373,-0.045252554,0.06846127,0.063385576,0.011428719,-0.033942364,-0.008552231,-0.07689921,-0.007867037,0.011086049,-0.005164445,0.014184362,0.0052565094,0.04279829,-0.11553955,-0.08798644,0.044434786,0.023901979,0.0152749065,0.011345086,0.018755985,-0.026410948,0.03107613,-0.092278495,0.030200308,0.133866,0.013380513,0.05364933,-0.03731366,0.0033189605,0.019100005,0.0057750377,0.0715647,-3.125645e-08,0.0010211325,-0.048515502,0.032159682,-0.08015448,-0.057209235,0.02197207,-0.007148001,-0.0056900517,0.0381422,0.0056983046,0.0524557,0.10420501,-0.013418323,-0.008212266,-0.07493187,0.05174787,-0.051432576,-0.015575992,0.02575079,-0.004441862,-0.10779328,-0.031971205,-0.11542824,0.04240902,-0.007258332,-0.07803084,0.013379737,0.012967653,-0.04741369,-0.04624421,-0.0021241037,0.09761286,-0.014858599,-0.031280316,-0.087845534,0.0029935914,-0.033402104,-0.054003257,0.02633826,-0.0015980758,0.04674576,0.01974719,-0.050399695,-0.013621127,-0.005525174,0.050470106,0.028970242,0.04150214,-0.10187482,0.02786139,0.0585804,-0.046384186,-0.065919876,-0.027653737,-0.07557152,-0.07186766,-0.01094163,0.018360035,-0.00695025,-0.0043951226,-0.03558109,-0.00049416034,0.17961858,-0.01758166 +2.5.1.155,"The enzyme, characterized from the archaeon Aeropyrum pernix, catalyses the first pathway-specific step in the biosynthesis of the core membrane C25,C25-diether lipids in some archaea. It does not act on geranylgeranyl diphosphate. cf. EC 2.5.1.41, phosphoglycerol geranylgeranyltransferase.",384,1.0,-0.059147257,0.014699889,-0.051727537,-0.07295119,0.018478505,-0.021338811,-0.041384272,-0.011800385,0.08059038,-0.030972136,-0.015035254,-0.09376672,-0.048550088,0.020727647,-0.06433844,0.04805686,-0.077974446,0.002584407,0.0075371806,0.0023970774,0.12894233,0.05463823,-0.03435447,0.013817676,0.001866437,-0.0011497108,0.0041174325,-0.052815,-0.02921725,-0.043810662,-0.018865632,-0.08707314,0.056071978,-0.050045248,0.08454268,0.09559059,-0.042694524,-0.030455247,0.019725403,0.00436504,0.06827271,-0.036030915,-0.01039667,0.009242305,-0.06913095,0.045670167,0.034048557,0.01986276,0.019384796,-0.01824601,-0.09560349,-0.08709328,-0.06382124,-0.060524903,0.022512708,0.08088503,-0.04946907,-0.0849608,0.034479268,-0.07761406,0.06541057,-0.027561268,0.019548003,0.013694054,-0.021764236,-0.06287128,0.09815952,-0.044097085,0.0910137,-0.06501501,-0.06722446,-0.047142714,-0.0026332175,0.0017467596,-0.021336948,0.056085266,-0.022589894,-0.016275926,0.015047426,-0.11462375,0.025004929,-0.009644865,-0.030112602,0.042587236,0.036158472,-0.0062781195,0.013898713,0.01824174,0.048082504,0.017162168,0.012764152,-0.06241086,0.008610392,-0.06579958,-0.08834269,0.052861124,0.013886977,-0.048301686,0.018478587,-0.017304504,0.021946171,0.011667233,0.02726286,-0.056765877,-0.058537412,-0.027302215,-0.013103986,0.06784409,-0.013844223,-0.0046122773,-0.037536055,-0.01150167,0.07623625,0.02182105,0.023983583,0.07114161,0.031230114,-0.053833567,-0.055396076,0.04774686,-0.074715994,-0.086807996,0.0128205605,0.05628985,-0.038508527,0.08580325,-0.11573635,4.7773284e-33,0.05319342,-0.008002809,0.0026190332,-0.0103178425,-0.016295716,-0.00655667,-0.08883711,-0.030227812,-0.026517548,-0.023339778,-0.061286416,-0.11308188,0.026116127,0.014850705,-0.023062311,0.013052359,0.0050894725,0.03042807,0.02026798,-0.02564605,-0.007808171,0.094230756,-0.04023314,-0.08219121,0.08570074,0.021119516,-0.013453128,-0.08049542,0.044236403,-0.0046699266,0.028178146,-0.13513961,-0.07367124,-0.018905068,0.09553406,0.014668119,0.01561681,-0.06115198,-0.05377558,-0.010722795,-0.06886021,0.04040817,-0.04086522,-0.02624834,0.057181217,-0.009065482,-0.07189213,0.16114683,0.053883407,0.009177592,0.014697941,-0.019910455,0.09454807,-0.004110705,-0.08965073,-0.013754575,-0.027889159,-0.00015808851,0.046948016,0.027043866,0.058500327,0.06353973,-0.06968042,0.017425641,0.118447125,0.08167583,-0.050522387,0.030842295,0.029751703,0.08135366,-0.041898873,-0.029198037,0.060901534,0.09618152,0.01363272,-0.020797221,-0.03914753,-0.022574166,0.016010761,0.036374018,-0.015722014,-0.006389095,0.047733426,-0.038712643,-0.019935932,0.06980407,-0.018343195,-0.043714266,0.00029031848,0.08744332,0.041093815,-0.042282075,-0.04800312,0.0973813,-0.08321526,-4.7422065e-33,0.05079984,-0.10871156,0.026702736,-0.08269232,-0.026918203,0.12699518,-0.019908806,0.0026927248,-0.0061529614,-0.06153051,0.04650789,0.021013025,0.07041769,-0.02397362,0.034553405,0.0024626106,0.04210651,0.05472834,-0.0021951038,0.0103255175,0.0065610926,-0.0011045978,-0.04283212,0.099778086,-0.018319698,0.010125776,0.030046193,0.07615122,-0.022558594,0.052416258,0.014399381,0.05827135,-0.05194773,-0.011904457,-0.063683234,-0.017429821,-0.081190415,0.068892755,0.03232321,0.0066308836,-0.0010314084,0.05353534,0.017735586,0.004055849,0.013837096,0.025957959,-0.02224941,0.021591248,0.015465376,-0.08778979,-0.030885123,-0.019059326,0.080043755,0.023272369,0.06925696,0.06495637,0.06637608,0.022920085,0.040765405,-0.07759717,-0.101645626,-0.056420535,0.0633722,-0.03470099,0.07566192,0.10361868,-0.00530923,0.023361592,-0.012930737,-0.03294092,0.03427212,0.012189103,-0.006124478,0.028368276,-0.019173713,0.05405868,-0.010943445,-0.09260187,0.01846495,-0.052715126,-0.010190275,0.042195536,0.013810955,-0.10603851,-0.013101597,-0.030484363,0.07519344,0.038256723,0.041423887,0.0235817,0.0076749786,0.016694536,-0.049286705,-0.006782635,0.10694601,-4.006878e-08,0.016625803,0.0098658465,0.087239005,0.0006112364,-0.045465738,0.060021415,0.05435761,0.010716175,0.02351712,-0.028733995,0.027312515,0.05661955,0.030984089,-0.020515034,0.029420216,0.07017827,0.012741188,0.00911179,-0.020609433,-0.06428054,-0.0648799,-0.025037304,-0.036402266,0.033589475,0.015030407,-0.08274264,0.07356792,0.034520518,0.0096724685,-0.08002839,-0.030922946,0.014495204,-0.022500433,-0.023335954,-0.029334633,0.07755221,-0.03575898,-0.037614826,-0.04238646,0.021047346,0.024869356,-0.022883136,-0.03824615,-0.017363487,-0.018932367,0.044495493,-0.045411143,0.030734612,-0.048454754,0.032261964,0.09537499,0.010142033,0.050870683,-0.038501512,-0.09071478,-0.038464718,-0.006978299,-0.056496702,-0.023664137,0.023498958,0.09877493,0.004170356,0.15029775,-0.011265665 +2.5.1.156,"The enzyme, characterized from the archaeon Aeropyrum pernix, carries out the second prenyltransfer reaction involved in the formation of C25,C25 membrane diether-lipids in some archaea. Requires a divalent metal cation, such as Mg2+. The enzyme cannot accept sn-3-(O-geranylgeranyl)glycerol 1-phosphate as the prenyl donor. cf. EC 2.5.1.42, geranylgeranylglycerol-phosphate geranylgeranyltransferase.",384,1.0,-0.06132252,-0.023672165,-0.02378487,-0.034408275,0.021711886,-0.02885831,-0.03580939,-0.032597855,0.051698044,-0.04229838,0.0012607097,-0.09594958,-0.04902066,0.01270214,-0.062842585,-0.009741218,-0.034879617,0.02405589,-0.028148638,0.0533712,0.11308224,0.0452443,-0.03261113,0.01906935,0.01867219,-0.0042244373,-0.006455452,-0.064176165,-0.005804365,-0.026307857,-0.008558885,-0.08877309,0.049566206,-0.06717171,0.06234212,0.08799127,-0.05006085,-0.0027688593,-0.034139413,-0.011384042,0.055816278,-0.040154878,0.023790153,0.012465948,-0.059430305,-0.003921252,0.06504603,-0.005121606,0.042421527,0.0023438805,-0.06848597,-0.09560343,-0.06545226,-0.07217589,0.018744964,0.06744815,-0.08434014,-0.08000605,0.0092042945,-0.11407137,0.0609812,-0.0070695705,0.0164585,-0.011765579,-0.011165148,-0.040231198,0.10014576,-0.067510664,0.08226608,-0.028711317,-0.014492718,-0.03903781,0.021729538,0.004792743,-0.030944517,0.09858643,-0.0018153108,-0.033133462,0.057636417,-0.059434477,0.036822334,-0.014804346,-0.013616385,0.04435247,0.007334479,0.017144015,0.0005071038,0.042065762,0.02169829,0.032029815,0.040887907,-0.019331945,0.028214697,-0.0594081,-0.10044884,0.017901018,-0.00621045,-0.034668397,0.040401652,-0.0023743738,0.017694457,0.021909788,0.054870173,-0.031943392,-0.05203457,-0.017662195,-0.037897766,0.048817206,0.032176424,0.032289423,0.0097025335,0.010038827,0.07559177,0.037972875,0.021953797,0.09565398,-0.011904526,-0.09347886,-0.04912271,0.0049400176,-0.06998388,-0.069587976,0.027069028,0.015195547,-0.021940356,0.06965272,-0.097658865,5.33126e-33,0.018814918,-0.032979112,0.019154761,0.020035543,-0.023796633,-0.014684877,-0.09246649,-0.02470729,-0.03411929,-0.03178029,-0.0790866,-0.09554678,0.013902903,-0.0048968224,-0.062103167,-0.007358363,0.007611029,0.0091030225,0.058546793,-0.029476164,-0.009902266,0.077724725,-0.0070432913,-0.07604365,0.10204953,0.037796177,0.019168565,-0.09886619,0.06601743,0.004020678,0.046420835,-0.15024711,-0.056834407,-0.021960638,0.092923634,0.013299459,0.027751578,-0.04164742,-0.047267575,0.0024106794,-0.068911105,0.0303975,-0.038040437,0.012041005,0.08638744,-0.037579197,-0.07580607,0.14939003,0.009723766,0.016752766,0.01966336,-0.0025989925,0.036787234,0.014608866,-0.108652174,-0.00024529017,-0.0073665786,0.04017696,0.062699586,-0.0043577,0.038826097,0.11207377,-0.022454776,0.018041845,0.12085791,0.059630573,-0.051532842,0.012219104,0.02020646,0.040231865,-0.010133102,-0.051258776,0.060408287,0.09154128,0.0040033828,-0.01099852,-0.026500598,-0.0053013857,0.06697783,0.01799189,-0.0509091,-0.014016922,0.04162338,-0.028811568,-0.0454606,0.0456723,-0.034689225,-0.046885435,0.019045152,0.07878606,0.067127004,-0.03644432,-0.072796136,0.074281804,-0.06944989,-5.3956076e-33,0.07257608,-0.12329934,0.053215574,-0.042410467,-0.04576542,0.12959714,-0.019116748,0.0030864687,0.024259612,-0.03646558,0.07885298,0.025500782,0.08176268,-0.06579545,0.04908878,-0.041742448,0.006964188,0.033436947,-0.0014482357,-0.0066134343,0.02433917,0.002295195,-0.061977413,0.11037446,-0.030391974,0.014167979,0.029363263,0.048144646,0.007169003,0.059257686,0.047901344,0.045537136,-0.039285783,-0.043878842,-0.058927074,-0.034831196,-0.044659443,0.071709864,0.010325309,0.0062982095,-0.0136473775,0.02664497,0.020528002,0.025121553,0.004774109,0.026760904,-0.017501684,0.009897869,0.077142864,-0.08227695,-0.030449843,-0.04572546,0.033230156,-0.0057942336,0.080246806,0.060858615,0.09311293,0.00838262,0.05633852,-0.06893064,-0.09175227,-0.074834205,0.11000406,-0.05309893,0.06568094,0.094509035,0.016185708,0.040666677,0.02726009,-0.044256847,0.02315845,0.024514847,0.0016025605,0.03924407,0.010032581,0.060226224,-0.015960561,-0.0667242,0.06304446,-0.08421187,-0.008937883,0.049427614,0.05109843,-0.07794496,0.02642532,-0.08416373,0.1141024,0.061067935,0.026822554,0.011154632,-0.012854594,0.0030321025,-0.07155527,-0.043611314,0.09013017,-4.6598032e-08,-0.010946122,-0.0020912352,0.07054153,-0.020680094,-0.065121226,0.04885956,0.044189624,0.025404075,0.027260646,-0.037560962,0.008890491,0.063489154,0.002494161,-0.05521795,-0.008705202,0.039285485,-0.018766483,-0.012239323,-0.043373365,-0.09522779,-0.07414639,-0.034526818,-0.0392065,-0.019871863,0.024680272,-0.07448259,0.026320549,0.074192755,-0.032754663,-0.069600165,-0.03738038,-0.0071143126,-0.04937067,0.0031715932,-0.02379202,0.04138328,-0.041267756,-0.019685136,-0.032458555,-0.011240874,-0.035154678,-0.025914775,-0.01547381,-0.0043968856,-0.00932617,0.01812651,-0.05131998,0.0605601,-0.05345235,0.039090846,0.10272224,-0.012153857,0.030054081,-0.041582584,-0.09658081,-0.022257168,0.0061919377,-0.036957823,-0.025980663,0.015138923,0.094804384,-0.028786346,0.117099635,-0.011908313 +2.6.1.124,"The enzyme participates in an L-arginine biosynthetic pathway that operates in certain species of archaea. In some cases the enzyme also catalyses the activity of EC 2.6.1.118, [amino-group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase.",384,1.0,-0.050904613,-0.08886704,-0.06376957,-0.021360096,0.06533712,0.06234361,-0.023517465,0.013163705,0.050560184,-0.0016865053,0.02845221,-0.03651983,-0.01821684,-0.0053933924,-0.03201443,0.032133114,-0.13324542,-0.084840424,0.001178061,-0.062411092,0.049749553,0.091758005,-0.062167738,-0.03725773,0.019628542,-0.023461446,0.048245575,-0.085754246,0.0025795181,-0.053365026,0.03869947,-0.10276352,0.034993846,-0.009953932,0.0474068,0.09043595,-0.060097616,-0.08850086,0.06261824,-0.030762259,0.038713384,0.001778066,0.0111680785,-0.07441539,-0.018138422,-0.001605433,0.07214956,-0.046951704,6.6772163e-06,-0.012150556,0.042337924,-0.05402813,-0.029197114,-0.006170946,-0.026305232,0.07421851,-0.10178826,-0.06902605,0.02803854,0.0027997482,0.045927234,0.07541662,0.007071442,-0.0027386446,-0.01194405,-0.07854451,0.07625028,-0.05853562,0.07259145,-0.07438287,-0.027203655,-0.077602625,-0.047734518,0.030005181,-0.008887425,-0.0013550187,0.0072121974,-0.023218688,0.049456414,-0.07649587,0.029653862,-0.048545733,0.0053254273,0.051089376,0.04039294,-0.06220125,0.03554942,0.06832442,0.042376354,0.019160854,0.08752276,-0.073558114,0.040907446,-0.020345602,-0.074426696,-0.0071395766,0.015858639,0.0244318,0.0009891299,0.0073902467,0.0066596186,0.09876693,-0.040830806,-0.06588671,-0.015536076,-0.02497275,0.0002535992,0.12230191,0.02055361,-0.04118699,0.016594095,-0.014594332,0.0438687,0.0541242,-0.027871057,0.089806415,0.05969249,-0.07551525,-0.08520672,0.04015088,-0.004294326,0.003918701,0.067125216,0.052994937,-0.048011515,0.07457988,-0.1113213,-2.3598777e-34,0.043727797,-0.012421768,0.007989827,-0.050544713,0.043892074,0.019003624,-0.10584519,0.007925951,0.046642307,-0.016119799,-0.09582537,-0.06496342,0.05755818,0.052715544,-0.020941963,0.029184595,-0.033906356,0.001318493,0.011847092,0.029405829,-0.05912093,0.028614152,-0.0058937366,0.009104106,0.05098453,0.005180263,0.059413973,0.0014895402,0.01815194,0.030928161,-0.04192551,-0.12894738,-0.0944761,0.0028511018,0.066790156,-0.004376866,0.021230035,-0.023918903,0.020280864,0.025851846,-0.00887061,0.057159968,-0.054450344,-0.017348675,0.03163459,-0.014080369,-0.0030792076,0.11202177,0.00016453414,0.058904413,0.011017603,-0.085856095,0.09610974,-0.021291716,-0.020873124,0.02522844,-0.049513403,-0.007403296,0.0850318,0.045527626,0.048222195,0.061710775,0.00081495446,0.0752567,-4.2304844e-05,0.027136011,0.012869889,-0.06582316,-0.021837985,0.060519334,-0.0818696,-0.04282444,0.124489374,-0.0136472415,0.007869987,-0.07933623,-0.09828062,-0.023546332,-0.00020174425,0.033004448,-0.035793908,-0.051636927,0.06454754,0.01259316,0.024338085,-0.027686397,-0.011826628,-0.02262021,0.027564,0.00788359,0.036567528,-0.008329015,-0.06882876,0.049773943,-0.008049081,-8.845256e-34,0.053816415,-0.106491715,-0.014717692,-0.11268784,-0.04865688,0.049014762,0.031225087,-0.008535741,0.039674968,-0.010599952,0.06882571,0.069547765,0.036763232,-0.07180957,0.0637233,-0.101145335,0.006459951,0.049431454,0.0259341,0.02428862,0.022760577,-0.051055804,-0.010552106,0.0050011375,0.04556136,0.006721372,-0.04234467,0.06909817,0.022678731,0.00096574693,-0.018684722,0.00417899,-0.025122155,-0.067192346,-0.04661303,0.028916243,0.0659528,-0.0020048572,-0.02142619,-0.019680701,0.04883684,0.08076176,0.019251473,0.059917547,0.030448765,0.06728157,0.0030628683,-0.01590493,-0.042340867,-0.10486414,0.046083,-0.08024443,0.06900937,0.009895806,-0.008039218,0.00041598507,-0.030713996,0.025621492,-0.017541042,0.052993864,-0.024901193,-0.080545254,0.019735882,-0.002632447,0.0150598185,-0.0125883445,-0.013705455,0.08111803,-0.032461282,-0.019038312,0.091914184,-0.06487899,0.022778044,0.10176169,-0.014860016,-0.0002922456,-0.05293895,-0.07919061,0.06821104,-0.09669014,0.013520674,-0.017938832,-0.010067512,-0.047132175,-0.02162623,-0.08072544,0.02805147,0.14805306,0.022818213,0.018595805,-0.06314617,-0.039217263,-0.045973778,0.0031545276,0.04734719,-3.3413464e-08,0.020331576,-0.010546445,0.034173176,0.0034765939,-8.433134e-05,0.046614382,-0.008110528,0.061897818,0.03783719,-0.033089265,0.048814856,0.050032273,-0.013681024,0.0051035658,-0.033407446,0.10591479,-0.012443497,0.075963475,-0.023713164,0.028897688,-0.015785761,0.010219527,-0.038588166,-0.0225828,0.037162445,-0.06653373,0.026843986,0.08644521,-0.05014283,-0.098484844,-0.024507485,0.025701359,0.0008494862,-0.0045551634,-0.10020217,0.015053623,-0.0088764895,-0.06239623,0.03230983,0.0073683206,-0.063762374,0.04301757,-0.07938717,-0.026518133,0.01412689,0.06788957,0.0134827625,0.014694219,-0.047245488,0.010918984,0.048540335,-0.07223771,0.041510034,-0.082667686,-0.069538444,-0.045888804,-0.057281364,-0.091055445,0.042846497,-0.044196602,0.07121633,0.04665212,0.12624133,-0.02238266 +2.7.1.237,"The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in a coenzyme A biosynthesis pathway. cf. EC 2.7.1.24, dephospho-CoA kinase.",384,1.0,-0.13688459,-5.9440677e-05,-0.11148003,-0.0032964603,0.055923346,0.023925247,-0.10816896,0.032994617,0.026525212,0.0075297714,0.0049826833,-0.13385774,-0.04071165,0.037638795,-0.077732734,0.006186886,-0.09158696,0.04113778,0.019576963,0.010040488,0.085441604,0.02519602,-0.035670232,0.075498015,0.017587937,-0.008446585,0.040928274,0.05291948,-0.009619461,0.043530405,-0.062021233,-0.01211686,0.1029781,-0.0047647427,0.08926884,0.12233987,0.015843106,-0.09177032,0.055487327,0.05358853,0.08985209,-0.0053006806,0.026105558,-0.013813436,-0.008983409,0.024631219,-0.033778034,0.023546517,0.038103547,-0.01677373,-0.06184446,-0.02450012,-0.058117464,0.024973268,0.03436007,0.10035713,-0.024776088,-0.03746493,-0.00328945,-0.06816184,0.0816062,-0.038180377,-0.02799169,0.110993944,0.018629104,-0.02824783,0.053614967,0.029330634,0.040561263,-0.072088115,-0.082279526,-0.03671184,0.014874307,0.052653324,0.00082205835,0.03899956,-0.023111824,-0.07958008,0.01926169,-0.025795273,0.043476284,-0.050110232,-0.010769297,0.040833287,0.0028571025,-0.035995755,0.054996416,-0.043177705,0.06300651,0.03933533,-0.008378206,-0.06292381,0.030382572,-0.0911009,-0.13494857,0.06492841,0.04903507,0.029724913,0.031216249,-0.02944889,-0.033095542,0.05543871,0.0049168807,-0.052653953,0.028318433,-0.03361418,0.012363951,0.057719287,0.0988465,0.053784907,0.012308911,-0.017096248,0.061564106,0.01299474,0.041247133,0.081658654,0.0019298744,-0.07821771,-0.034357958,0.09165962,-0.029987978,-0.02610989,0.0092980545,0.04788719,-0.08887565,0.053745404,-0.11086807,-8.317405e-34,0.027190832,0.012725284,0.055562746,-0.013854347,0.053647682,-0.06914883,-0.069056846,-0.014269959,-0.07906525,-0.08370014,-0.091454394,-0.0008894117,0.079625204,0.06631718,-0.015996011,0.0212266,-0.009473508,-0.008219118,-0.000653805,0.06272971,0.0011216715,0.021825954,0.007592059,0.022523,0.052231044,0.0044508423,-0.02817641,0.014181888,-0.01975717,0.024580702,-0.011356009,-0.045838628,-0.07780826,0.0009390122,0.065453716,-0.056680784,-0.07715995,-0.052052192,-0.0379037,0.03357477,0.029494027,-0.029245263,-0.037719157,0.014258928,0.051762108,-0.01881474,-0.01976774,0.107751705,0.029068738,0.061276488,0.008989093,0.0016704183,0.018609967,-0.02470478,-0.048373193,0.0052046543,-0.05167533,-0.051115192,0.03754493,-0.03313387,-0.051047698,0.06779051,-0.060694505,0.0967517,-0.037196606,-0.016409745,-0.11844294,0.0158688,-0.00048596098,0.041383766,-0.0712516,-0.039231837,-0.04386416,0.01360549,0.008315515,0.02439373,-0.015418744,-0.04774162,-0.010528941,0.01887624,-0.03178244,0.042852312,0.039862543,-1.5650907e-05,-0.059740923,-0.051866185,0.049060185,-0.0050419327,-0.015499992,0.05088882,0.04531448,-0.07854407,-0.019996408,0.055435043,-0.0048187138,-9.948079e-34,0.100019254,-0.08689382,0.022336302,-0.11292716,-0.08015812,0.056298662,0.039545406,-0.047320116,0.06097744,-0.04618258,0.13047948,0.018671876,0.02956168,-0.037480794,0.07430026,0.001706622,0.02599864,0.09445489,0.00428422,-0.012389422,0.05374381,0.019383324,-0.036213554,-0.058895428,0.0023112812,0.0067368634,-0.01405134,0.07005715,-0.03148449,0.063821346,-0.049198408,-0.0035990938,-0.026367998,0.0025489454,-0.030407025,0.04430605,-0.03401536,-0.04738114,0.051722616,-0.039708342,-0.006483358,0.026503343,-0.052578304,0.04194701,0.053570785,0.00036869914,0.013763098,-0.048118226,0.03700577,-0.004723243,0.03254656,-0.046550084,-0.033813056,0.034457237,-0.047541145,-0.0018005377,-0.05832652,0.09436665,0.0020278867,-0.04583146,-0.043263864,-0.018719742,0.046948098,0.046892192,0.07623722,0.06242574,-0.05833627,0.050928686,0.010277082,-0.0258148,0.073052086,0.07883677,0.035988417,-0.0067879185,-0.024614766,-0.0749557,-0.11775112,-0.022967352,-0.04449595,-0.022042826,-0.095697954,0.041227095,0.021970024,-0.008750557,-0.0735201,-0.054017954,0.06311574,-0.011880847,-0.038831655,-0.0044627963,0.0056715026,-0.026649076,-0.066000864,0.074378096,0.059045203,-2.9791845e-08,0.005141489,0.009418411,0.052044146,-0.05337565,0.08196402,0.04843826,0.033447977,-0.0010466677,0.06717448,0.007670847,0.063336454,0.04606063,0.08121955,0.013888314,0.03975382,-0.0067517576,-0.05762095,-0.020982679,-0.047152206,-0.030144291,-0.017724311,-0.07282341,-0.028208943,0.052345697,0.0013121789,-0.070884265,0.014500271,0.055716638,-0.0073921406,-0.06382677,-0.047039974,-0.02761832,-0.038549934,0.005370611,-0.052404445,0.03056512,-0.03194627,-0.06044347,-0.051337477,0.030928154,0.052600913,-0.0105221,-0.027359191,0.056150157,0.057576176,0.0003880768,0.06720928,0.056220572,0.0062717916,-0.00943261,0.035435244,0.0018095231,-0.030585008,-0.020966558,-0.09486502,-0.09300662,0.0028793495,-0.030322058,-0.03817173,0.005639058,0.026707383,-0.017067807,0.1868874,-0.05150575 +2.7.1.238,"The enzyme, characterized from the bacterium Thauera aromatica, catalyses the first step in an anaerobic phenol degradation pathway. The enzyme, composed of three subunits, transfers the beta-phosphoryl from ATP to phenol, forming phenyl phosphate, AMP, and phosphate [1]. During catalysis a diphosphoryl group is transferred from ATP to a histidine residue in one of the enzyme's subunits, from which phosphate is cleaved to render the reaction unidirectional. The remaining histidine phosphate subsequently serves as the actual phosphorylation agent [2].",384,1.0,-0.051296137,0.0012087487,-0.08646341,-0.0435384,0.045603126,0.042165816,0.0025113325,0.01257719,0.08365378,0.018834105,0.0076251593,0.012799348,-0.044986844,0.03042876,-0.063800424,0.0246118,-0.08413393,0.04068741,-0.029096995,-0.08993119,0.08113482,0.02302703,-0.031946253,-0.004277871,0.010537922,-0.010641435,0.06554668,-0.051503964,-0.073239274,-0.05006134,-0.015781885,-0.035892196,0.047640182,-0.05489735,0.044883627,0.1742983,-0.043356944,-0.10359655,0.051282484,0.06759965,0.047131095,0.002160692,-0.064870276,-0.015190311,-0.04930691,0.007623253,-0.009599326,0.072787315,0.061561525,-0.04675854,-0.08502413,-0.0013394326,-0.024842197,0.011923307,-0.0040924973,0.07249326,-0.040166784,-0.011775364,-0.074285775,0.05207072,-0.012083639,-0.014576429,0.026537213,0.029850326,0.0386044,-0.07967157,0.046639644,-0.06440474,0.051161442,-0.01151565,-0.111757055,-0.07470519,-0.014717861,-0.011222429,0.021316439,-0.027194574,-0.012126415,0.053880215,0.025467262,-0.04801984,0.0060101133,-0.041439615,-0.007853864,-0.009913205,0.050191816,-6.313039e-05,-0.038894247,-0.035744146,0.14345483,0.06556526,0.024813173,0.03129085,0.03792524,-0.07504022,-0.053394683,0.019278478,0.068697825,-0.0062116277,-0.021597562,0.0016298735,0.066533774,0.066138044,-0.03254271,-0.06418788,-0.021634992,0.025128417,0.014136196,0.0970452,-0.0066200746,0.02622487,0.000596175,0.017867178,0.062897235,-0.010155236,0.014610797,0.0887909,-0.017500687,-0.053258825,-0.09246329,-0.015340068,-0.056064952,-0.0955182,0.01991192,0.065583445,-0.081437975,0.019007431,-0.09327749,3.932722e-33,0.096046224,0.046768617,-0.012293807,-0.0031060956,-0.03388118,-0.0098984,-0.0719401,0.03143025,0.005658171,-0.11726935,-0.009891105,-0.090091795,0.016473074,-0.024890104,-0.050176825,-0.06441305,-0.047382906,0.09286278,0.119706996,0.007598547,-0.0019099347,0.03657088,-0.0005822851,-0.031740535,0.056433015,0.06952676,-0.06406331,-0.015403729,-0.040191002,0.0022772476,0.039629277,-0.073046625,-0.13459256,-0.017380351,-0.018472755,-0.054121643,-0.08344817,-0.017047102,0.0045684287,0.03366841,-0.03177055,0.03129534,0.030360036,-0.0026433086,-0.020985577,-0.032432288,-0.00071638246,0.07636465,0.05812915,0.059070442,-0.009201293,-0.0552017,0.16707404,-0.032391593,-0.07346345,0.057800584,0.040245883,-0.048149116,0.030050522,0.025523156,0.060415033,0.08199772,-0.043027077,0.030055946,0.042397033,0.017054109,-0.1035729,-0.02435957,0.048926514,0.120649815,-0.04598757,0.022310173,0.036094688,0.036003083,0.011754483,-0.03963048,-0.0978311,0.023548031,-0.049958434,0.06480721,0.041125637,-0.03279322,-0.028560424,-0.017261194,-0.04119963,0.010131735,0.07193859,-0.08536629,-0.011597605,0.023105882,0.04092252,-0.08356968,-0.030286258,0.0027068814,0.08163257,-4.4514145e-33,0.13576123,-0.09727897,0.026822025,-0.053452592,-0.021508057,-0.028080342,0.0162795,0.018059332,-0.017188013,-0.0017799838,-0.0021101036,-0.018045777,0.009467913,-0.031883266,-0.02689587,-0.023845816,0.07053767,0.032190535,-0.025029456,-0.016217362,-0.017324904,0.05279908,0.049739685,0.035843063,0.0022133118,-0.005426925,-0.013628321,0.032621466,0.033508465,0.008172119,0.02875541,0.02834877,-0.049870357,-0.032499377,-0.026191443,0.029965391,-0.10566701,0.013200103,0.0465855,0.029636336,0.11515382,0.029852197,0.040704455,0.014106371,0.03480459,0.05770807,-0.044820953,0.05279509,-0.07521425,-0.08816186,0.015341826,0.04715372,-0.038982198,0.031834476,0.08316829,0.06665285,0.0039436454,0.0068510137,-0.010775701,-0.04720955,-0.04373882,-0.059004787,0.0034478311,0.012804993,0.022484053,0.03330969,-0.0328679,0.07360746,0.019761309,-0.0010956218,0.07575819,0.011493184,0.037141796,0.04801909,-0.046100687,-0.04352523,-0.052607253,0.0059772246,0.02402587,-0.0429811,-0.026333189,-0.04665493,-0.056782123,-0.10266177,-0.0038263518,-0.08076453,0.044766743,0.033185177,-0.04000243,0.005613768,0.032063726,-0.074881926,-0.018054072,0.07110435,0.030293833,-4.2184197e-08,0.013693356,-0.023802936,0.057257228,-0.0019574696,0.018171402,0.0415866,0.0419475,-0.004357238,0.08201556,-0.017797641,-0.024137437,0.035574425,0.039695922,0.0025653362,0.049207114,0.060748845,-0.108217224,0.010874506,-0.010476274,-0.056370948,-0.009461135,-0.03307725,-0.13255803,0.07320627,0.07987915,0.018224256,0.04061071,0.040531635,-0.022743495,-0.05244583,0.00077273586,0.013334072,0.018121963,0.0038493653,-0.004152008,-0.012647743,-0.028869638,-0.0020863246,0.010635978,0.032625347,-0.06267082,-0.0027415797,-0.12253481,0.028775929,0.024177644,0.08220207,0.01511035,0.05280283,-0.024498362,-0.023198277,0.014070601,-0.035079062,-0.010772789,-0.037973523,-0.091872156,-0.03400205,0.0030594887,-0.033893082,-0.01850685,-0.021187428,0.06940925,0.047452066,0.12391384,-0.056677096 +2.7.2.19,"The enzyme participates in an L-arginine biosynthetic pathway in certain species of archaea. In some organisms the enzyme also catalyses the activity of EC 2.7.2.17, [amino-group carrier protein]-L-2-aminoadipate 6-kinase.",384,1.0,-0.030489637,-0.07888327,-0.08013933,-0.0128810415,0.094372645,0.0560276,-0.0625863,-0.014754999,0.05038421,0.032081034,-0.017168414,-0.03707892,-0.047952894,-0.013923159,-0.06512944,0.061573826,-0.15400487,-0.034417838,0.012584534,-0.04215898,0.037916582,0.06176923,-0.052488297,-0.020878581,0.0014766237,-0.032296333,0.042555377,-0.048763506,-0.025813503,-0.055820115,0.021711709,-0.08806849,0.059429776,-0.027625676,0.024610361,0.14203478,-0.06788878,-0.086161695,0.052837096,-0.023186265,0.05115198,-0.05339779,0.0035259954,-0.0757267,-0.026268866,0.01267169,0.06258802,-0.025712257,0.030677034,0.006971728,-0.0011567574,-0.049051754,-0.045257248,-0.0056822225,-0.039613817,0.068682976,-0.105844155,-0.062357306,0.025565207,-0.031333733,0.06923863,0.030367758,0.021259472,0.018144766,-0.033821017,-0.08243573,0.06782545,-0.04481185,0.06089281,-0.05016677,-0.033338353,-0.08224377,-0.013209178,0.0452561,-0.0052832426,0.0037789792,-0.02146406,-0.03979144,0.065385714,-0.08092255,0.023637937,-0.048660163,-0.0159081,0.050945424,0.01950722,-0.051172554,0.035599865,0.037867382,0.029044636,-0.0007884674,0.11660711,-0.063200966,0.04405424,-0.060493194,-0.05880689,-0.01894442,0.018174894,0.03252444,-0.02426443,-0.001416837,-0.007501587,0.075122975,-0.07789819,-0.07834246,0.013340011,-0.040669106,-0.008606793,0.12354065,0.026248593,-0.01667329,-0.007989518,-0.013015046,0.045590833,0.06239067,0.0025427486,0.11493055,0.06089366,-0.10198889,-0.080332875,0.046204414,-0.029197643,0.0053699473,0.074358664,0.060576305,-0.056442156,0.053946976,-0.0839327,-9.173757e-34,0.03539916,-0.0046913936,0.031233298,-0.04010994,0.04514706,-0.012932387,-0.0824815,-0.01858394,0.05033367,-0.023567447,-0.087547675,-0.067759976,0.09045968,0.037143987,-0.020231796,0.026031481,-0.017749026,-0.006800622,-0.005140594,0.038258765,-0.053051516,0.03033328,-0.019481093,0.01931286,0.04405791,0.009584932,0.076134935,-0.011273058,0.005385328,0.027909152,-0.04373969,-0.09630782,-0.094671965,0.006464624,0.08733244,-0.023170236,0.011820874,-0.019216413,-0.0006701598,0.018939804,-0.013072147,0.04084634,-0.042981748,-0.0137831,0.031504825,-0.01452957,0.0027722176,0.14441063,0.027760213,0.042073194,0.03641249,-0.05857813,0.102196656,-0.035389327,-0.019639708,0.020310458,-0.06475746,-0.00074029114,0.089445785,0.029272728,0.021412183,0.028309131,0.011498901,0.09584824,-0.009463643,0.044455934,-0.016738432,-0.04695568,-0.024388451,0.08247913,-0.07231311,-0.017487926,0.110266164,0.007070441,-0.026968535,-0.044802714,-0.089453615,-0.047586225,-0.026626265,0.036309723,-0.0066929194,-0.07071539,0.05901129,0.035948433,-0.0046557845,-0.036118828,-0.016673632,-0.031394113,0.032547116,0.0058039315,0.053682018,-0.027493563,-0.108136296,0.0552667,0.0024723844,-1.0971827e-33,0.11023795,-0.10718888,0.0029006093,-0.09120948,-0.06307053,0.07306613,0.044846833,0.0016726244,0.013048596,-0.009960098,0.08140438,0.07102781,0.052063163,-0.054008592,0.058394015,-0.08433937,0.005809212,0.039681476,0.046924576,0.01423789,0.0077087567,-0.06395584,-0.035731517,0.0053776745,0.037032682,0.017334135,-0.05965332,0.058877915,-0.023181003,-0.00430162,0.0062847375,-0.012851878,-0.016528891,-0.04308806,-0.03258805,0.038652305,0.024039762,-0.025253875,-0.027245736,-0.033598907,0.044442747,0.0374194,0.0095347455,0.062652126,0.042361032,0.0055625895,0.004838328,-0.005678347,-0.023744296,-0.13392903,0.033450373,-0.08122644,0.057171974,-0.005963477,0.008877682,0.023298845,-0.045341562,0.044725396,0.0131816305,0.05493068,-0.012364539,-0.07147313,0.03956845,0.002621696,0.015593105,-0.0036892835,-0.043348543,0.092036344,-0.030943986,-0.007512494,0.072560355,-0.031301048,0.03712688,0.098936215,-0.018198978,0.009220784,-0.01836909,-0.0699173,0.048988715,-0.07036682,-0.022482676,-0.0031813378,-0.017308017,-0.027879693,-0.072823815,-0.06174348,0.06766365,0.12534599,-0.005179821,0.020356605,-0.042658467,-0.045222357,-0.08247099,0.007990913,0.047443017,-3.2519022e-08,0.058828104,0.003714594,0.059842795,-0.014664529,0.0027741275,0.047218237,0.006810559,0.07785676,0.027115857,-0.039428975,0.038320664,0.03201975,0.03006315,0.0003296336,-0.00050018175,0.0860207,-0.030946083,0.062316146,-0.040702146,0.019436926,4.1599662e-05,-0.020193558,-0.049897753,-0.018211197,0.046535037,-0.07526401,0.008279573,0.07657817,-0.04085822,-0.07038041,-0.016225474,-0.01137925,0.009581889,-0.0034259544,-0.06900222,0.07148724,-0.05567243,-0.09980534,0.02805656,0.0022308151,-0.05399526,0.045685858,-0.06586684,-0.021981133,0.0013977682,0.06445657,0.026929606,0.003844389,-0.041194044,0.016745036,0.025259411,-0.039326042,0.04269512,-0.07578667,-0.04986878,-0.036288746,-0.0634995,-0.087758526,0.037603006,-0.04962845,0.08715522,0.039663408,0.13003662,-0.018623073 +2.7.11.34,"Requires Mg2+. NEK6 subfamily kinases are present in animals, though lost in insects, and include human NEK6 and NEK7 and C. elegans nekl-3. They are activated in mitosis by phosphorylation by NEK9 [1], and phosphorylate cytoskeletal proteins including EML4, KIF11A and KIF14 [4,2]. In C. elegans, nekl-3 is involved in clathrin-mediated endocytosis [5]. In peptide arrays, NEK6 prefers to phosphorylate Ser residues, with hydrophobic residues at -2 and +1 and charged residues at -1, -2 and +2 [3].",384,1.0,-0.09211132,-0.024576494,-0.020643188,-0.014857491,0.07186801,-0.030065432,-0.00353042,-0.05142758,0.061416242,-0.0014197617,0.020879438,-0.037622046,-0.051413197,0.038357116,-0.044407383,0.07133425,-0.030404652,0.10000715,-0.085591316,-0.010077029,0.021246053,0.015172921,-0.008952836,-0.0017357443,-0.027755871,-0.05281188,0.040785555,-0.004792604,0.022522595,-0.01819867,-0.050063577,0.008995193,-0.05001749,-0.011106801,-0.0006174308,0.12136821,-0.083574675,-0.03304331,-0.020519689,-0.08722055,0.078862615,-0.011110918,0.003621876,-0.054283533,-0.03261248,-0.007228284,-0.021348737,-0.06538664,0.098443165,0.019338096,0.0005951937,-0.044941306,-0.04854659,0.051042035,0.0072635305,-0.0330565,-0.1639751,-0.012387221,0.04714668,0.014677895,0.0013619224,-0.033914786,0.06633773,0.016014105,0.0488369,-0.022126434,0.0046266406,-0.018336339,0.008409226,0.034859944,0.02003514,0.010459114,0.05585893,-0.02527418,-0.040157788,0.11115083,-0.01663911,0.009312071,0.019672275,-0.04003406,-0.014304057,0.01204278,0.101773456,0.12949356,0.019386245,-0.0004231427,-0.034245934,0.028776517,-0.042782847,0.059560306,0.106291614,0.0057400567,0.032925844,0.0005540394,-0.027128039,0.042240787,-0.0256927,0.017339248,-0.0730019,0.026392706,-0.059838105,0.0858073,0.005755031,-0.030100338,0.061581623,-0.013954498,0.00024226532,0.04640249,-0.031176854,0.0043889885,0.01281306,-0.022029143,0.057933416,0.0346306,0.059701473,-0.0037778078,-0.063143186,-0.012111708,0.09415688,0.03416667,0.020094404,0.01931362,-0.093243316,0.023988537,-0.018727105,0.07981014,-0.09655367,4.2657114e-33,-0.0053947666,-0.005899723,0.07559795,0.041212335,-0.055016883,-0.048324145,-0.01866318,-0.06330329,-0.026181255,-0.0857499,-0.051752973,-0.025682764,0.015036956,0.017096879,0.004641638,-0.041441295,-0.016120885,-0.03995087,0.06550482,0.04230408,0.039248116,0.02858108,0.020574031,-0.12583749,0.012821951,0.037763044,-0.08885255,-0.022483902,0.014981048,0.0035113057,0.045053884,-0.009380631,0.020429974,0.09615665,0.0012764401,0.04887904,-0.021851458,-0.036806982,-0.01569582,0.0071258885,-0.018909933,0.0031463038,-0.14875512,-0.016920343,0.027053565,-0.09121999,-0.019957772,0.09656419,-0.009245564,-0.03902263,0.061894998,-0.019393252,0.040401727,-0.014845708,0.0062044724,-0.102426514,-0.038067114,-0.04779976,-0.021971552,0.028157756,0.0057155313,-0.041988485,0.0068637915,0.08367864,0.115259044,-0.022121064,-0.106475815,-0.07368245,-0.091897495,-0.025520196,0.03157296,0.012107649,0.060749132,0.039269943,-0.06931754,-0.020020096,-0.0003490393,-0.022866534,-0.08094402,0.12883198,0.07061634,-0.05116185,-0.03410007,-0.0030746837,-0.076207966,0.0050048064,0.017788038,-0.04941409,0.048310507,-0.02736471,0.03634218,-0.023805171,-0.073233984,0.051149834,-0.045062654,-5.18635e-33,0.056384403,0.0018400567,0.043661598,-0.019753417,-0.11453718,0.1432017,0.113467775,-0.079217665,0.023515403,0.012108593,0.013523328,0.043137304,0.021208992,-0.061487086,0.00030786925,-0.07214892,-0.013050901,0.05296276,0.095951736,-0.09487757,-0.048581246,0.087885536,-0.02886015,0.05705661,0.110334836,-0.0002605043,-0.03402679,0.039059598,-0.1155273,0.017688634,0.026129732,0.013170304,0.02788763,0.040734395,0.03451119,-0.005309782,-0.029066283,-0.09056332,0.0775101,-0.07619042,0.024797278,-0.0015832304,0.03898038,0.038866427,0.047024205,0.016709028,-0.012799157,0.12089655,0.012386195,-0.088380076,-0.012359578,-0.055994224,-0.07312976,-0.012520428,0.027983235,0.0744588,0.015007485,-0.015002676,0.078340024,-0.02916568,-0.07442289,-0.03939629,0.058760375,0.01886121,-0.04690393,0.07788652,0.02801489,0.07393245,-0.019925606,-0.028543234,0.024554774,0.05146181,0.01595945,-0.03205922,-0.016721856,0.010194186,0.032661892,0.027179895,-0.007400816,-0.087900646,-0.08913593,0.0288923,-0.046102274,0.011423914,0.02322304,-0.011117261,0.013704565,0.045527626,-0.006733022,-0.03831456,-0.009938671,-0.06010834,-0.053407703,0.105759636,0.013355339,-4.291162e-08,0.06508288,-0.013962115,0.00915511,-0.0944771,-0.00064898934,0.011479894,0.03024098,0.028086025,-0.044906046,0.044839624,0.073835574,-0.038779676,0.027694402,-0.04927549,0.030873677,0.062155824,0.069444485,0.06318525,-0.0015322055,-0.08942029,-0.009542793,-0.06907226,-0.051875386,0.037460722,0.022257054,-0.06867588,-0.011092111,0.05421881,0.02061061,-0.034557268,0.011072403,-0.06684562,0.034882814,-0.027183909,0.04238413,0.08804548,-0.099096805,-0.062489346,0.013927188,0.018423881,-0.0471122,0.026022268,0.044762563,-0.0776653,-0.05476333,-0.014111924,0.045822307,0.004583624,-0.057942823,0.058530346,0.013370788,-0.002591455,0.013713029,-0.020396618,-0.044588383,-0.014713001,0.032660037,-0.06088441,-2.0280158e-05,-0.03780493,0.020982897,0.032485437,0.0042712092,-0.009908948 +3.4.21.122,"The enzyme, present in mammalia, cleaves and inactivates EC 3.4.17.23, angiotensin-converting enzyme 2 (ACE2), at arginine residues in the region R697 to R716, which enhances influenza and coronavirus uptake [7]. The enzyme also cleaves and activates influenza and coronavirus spike glycoproteins and thus facilitates virus-cell membrane fusions. The cleavage of SARS-COV2 spike glycoprotein occurs between the S2 and S2' site at SKPSKR/SFIEDL, while the cleavage of MERS-COV glycoprotein occurs at GSRSAR/SAIEDL.",384,1.0,-0.025029058,-0.027196165,-0.12772083,0.01181783,0.101741135,0.021142114,-0.028020605,0.043671746,0.05742351,0.0056415484,-0.029307405,0.064587325,-0.040215004,0.07380479,0.0103691155,-0.029618504,-0.08743017,-0.04966016,0.03667828,0.004273834,0.050110556,0.009494058,-0.072526924,-0.02687248,0.056189384,0.053981412,-0.029920971,-0.057247136,-0.015534439,-0.0011800927,0.009661825,-0.11519549,0.016716162,0.024324147,-0.0023786607,-0.007405206,0.023152266,-0.009692924,0.017942319,0.03010328,0.033906046,0.024849437,-0.01353464,-0.10943431,0.07242856,0.059441805,0.0002746264,-0.0006287217,0.033956323,0.06291666,-0.06292671,-0.09799512,-0.050175082,0.012336826,-0.005381787,0.091238685,-0.15506554,-0.02539266,0.037212953,0.030392077,-0.0053971857,-0.030214174,0.06562442,0.02148311,-0.059103668,-0.13271923,0.051097825,0.050463855,0.039467603,0.07007865,0.019106096,0.04297251,-0.072492085,0.007209802,-0.015106251,0.055057798,-0.008037789,-0.0155330645,0.1361371,-0.061625745,0.020793902,-0.020501241,0.054779127,0.08065869,-0.013832675,0.021517405,0.024801614,-0.03425388,0.028297322,0.0075199823,0.046706565,-0.062686406,0.010678396,0.05249789,-0.021286594,0.037257914,0.051499885,-0.0031340395,-0.01947057,-0.00712577,-0.028594576,-0.0009607149,0.08846638,-0.057723198,-0.0013341261,0.012919219,-0.063849084,0.078328654,0.031806227,-0.047850456,-0.014003649,0.10642981,0.039514206,-0.05295771,0.056435533,0.11898522,-0.016581174,-0.10496725,-0.025656998,0.007277919,0.038923316,-0.058337383,0.014187703,0.08853926,0.020100463,0.09443075,-0.028279833,2.5786528e-33,0.047473952,-0.010527634,0.07456328,0.037694983,-0.06035038,-0.07018818,-0.047439605,0.035108313,-0.043295544,-0.026413148,-0.06789255,-0.053894028,0.06269657,0.102940165,0.0074983966,-0.008987804,0.037256435,-0.042626902,0.04032976,-0.030313307,0.06220043,0.019491635,0.016110841,0.022506015,0.05734767,0.0012766477,0.008937746,-0.012764703,0.09653805,-0.00028255006,0.0144261,-0.03897185,-0.036526676,0.05650228,0.016210202,0.020896183,-0.04136456,-0.042953312,-0.0061170366,0.082732625,0.16405436,-0.009787944,-0.020517234,-0.026322445,0.03419018,-0.06291078,-0.043825887,0.06688096,0.007993468,0.038371887,0.016151834,0.010572737,0.07787271,0.050873395,-0.05086444,-0.004638888,-0.0006191794,-0.06402751,-0.012132922,-0.030543245,0.0059269876,-0.03344032,0.021438135,0.08725716,-0.029300533,0.006523684,-0.0037371754,-0.038000666,-0.00038275562,0.07802403,0.015677333,0.0013771908,-0.0007835789,-0.024682214,-0.0039892825,-0.036903873,0.0015184706,0.024616325,0.052895945,0.052108,-0.10491945,0.039865024,0.059443716,0.042218406,-0.1043372,-0.08617485,-0.0036093968,-0.14333895,0.0074945143,0.0544352,-0.008950246,0.07654584,0.019781537,-0.0062949494,-0.06900547,-4.1397223e-33,0.031704772,-0.110574156,0.023695173,-0.0353151,-0.12153063,0.14858235,0.016228165,-0.049314477,0.01869406,-0.06599637,-0.02111476,0.009683947,0.032594804,-0.06807814,0.018155456,-0.064229324,-0.0024491176,0.054406203,-0.030370114,-0.015498281,0.0011396419,-0.006184342,0.11025194,0.025332207,0.08101908,-0.016333641,-0.009505591,-0.025075084,-0.006085354,0.003168685,-0.0042130984,0.0029580607,-0.05922247,0.032556694,-0.07758941,0.025774626,-0.007751647,0.0016246641,-0.0036368638,-0.08957524,0.005608853,0.0488414,0.022988783,0.060014386,0.04622934,0.06525413,0.054355785,0.059076518,-0.017092764,-0.092919156,-0.030178508,-0.0720513,-0.04024633,0.03657192,0.00049358857,-0.0068786857,-0.024367334,-0.05800761,-0.011529621,-0.043662578,-0.020456288,-0.071201004,-0.10662511,-0.06051826,0.07824245,-0.02300345,0.031815413,0.009868681,0.0143306665,-0.08579931,0.058389913,-0.008570082,-0.016992627,0.016698375,-0.038214315,-0.009596348,-0.036200736,-0.02428424,-0.018925564,-0.10392046,-0.046088,0.040931292,-0.013409899,-0.10223069,-0.03761167,-0.0024087275,0.013254808,0.118815124,0.016515777,0.031012394,-0.10256606,-0.06047137,-0.01645357,0.006920888,-0.019203689,-4.13492e-08,0.06041978,0.014268099,0.002208265,-0.05065555,-0.0680965,0.101210706,-0.011086329,0.06830202,0.03056613,-0.019369785,-0.040714893,0.017747266,0.084982894,-0.05172869,-0.05610639,0.029005928,-0.06992039,0.05273873,-0.029174138,-0.03924232,-0.04263498,-0.024393255,-0.06700674,0.043268673,0.0017703725,-0.06644431,-0.02799819,0.06374298,0.034192722,-0.08392599,-0.038928043,0.006269811,0.03516174,-0.01929287,-0.011586399,-0.01820096,0.06529217,0.005374196,0.025284348,0.027889239,0.029417653,0.0050076437,-0.052574545,-0.0186729,-0.057481717,-0.024829369,0.019363,-0.023242213,0.02313768,-0.047931723,-0.0025636016,0.019273143,-0.013820822,-0.07579701,-0.104609005,-0.0028771602,-0.042515326,-0.061598983,0.038487256,-0.031611457,0.0040497174,-0.013881033,0.015221195,0.07871281 +3.13.2.1,"The enzyme contains one tightly bound NAD+ per subunit. This appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond [2] (for mechanism, click here), cf. EC 5.5.1.4, inositol-3-phosphate synthase.",384,1.0,-0.13221104,-0.024403857,-0.07698895,-0.017687408,0.07457212,-0.053911325,-0.07874955,0.035552774,0.065732256,0.06326748,-0.004005164,0.004727051,-0.066703826,0.028472412,-0.03995246,0.047953065,-0.052067276,0.015338535,-0.026479157,-0.07272543,0.065665066,0.027235271,0.0008154889,0.010841939,0.08819278,0.07061926,0.07128262,-0.022841174,-0.030705113,-0.079862826,-0.111394,-0.026454912,-0.0057784184,-0.049049716,0.029535621,0.14378424,-0.111908026,-0.05564336,0.042357598,-0.014682681,0.050741557,-0.01071949,-0.08056329,0.00058594526,-0.098476745,-0.05569826,-0.034975868,0.0949736,0.0840845,0.01072867,-0.05119129,-0.031677186,0.029868217,-0.060436558,-0.049993522,-0.032041326,0.01051363,0.04610547,-0.057777055,-0.028735334,0.04118368,-0.02246529,-0.01080392,0.053604357,0.05041849,-0.023627939,0.089509584,-0.0074627837,-0.054397553,-0.03318244,-0.074461155,-0.014239354,0.02954716,0.018755188,0.010712799,0.04694654,-0.04048319,-0.029517747,0.06476048,0.0075098756,0.07247371,0.035968196,-0.023407245,0.07712927,0.0485203,0.02774354,0.00174755,0.03404631,0.042726785,0.017041732,0.0112120975,-0.013644271,-0.11997748,-0.00533374,-0.08201791,0.043679874,-0.013132269,0.068400934,-0.01809281,-0.046210013,0.060136344,0.08532457,0.008432273,-0.03818494,-0.02856473,0.014561956,0.015449077,0.06847826,0.0010378226,0.013513248,-0.015941534,-0.042386666,0.075274885,-0.032123674,-0.029088654,0.12323069,-0.01677555,-0.019443972,-0.02949613,-0.032550525,0.023917336,-0.04434412,-0.019981088,0.038880177,-0.09850047,0.020266013,-0.1015867,1.2956963e-33,0.08009405,0.08240811,0.009551968,0.02539035,0.022112032,0.033444036,-0.038931902,0.023167504,-0.13277125,0.0010440927,-0.029566698,-0.072265305,0.06962766,-0.076586045,-0.014421878,-0.030585794,-0.04633821,0.016740436,0.006602309,0.039710887,0.038825467,0.035741646,-0.080452435,0.036209602,-0.051990613,0.10076279,-0.04117462,0.052828245,0.037649713,0.016788099,0.021931328,-0.07504478,-0.07941865,-0.041388214,0.05718824,-0.0726259,-0.033079337,-0.012305489,-0.02468989,0.074472494,-0.030346168,0.030626176,0.015664108,-0.032732695,-0.008360067,-0.10460618,-0.011791735,0.083242714,0.038195346,0.051974747,0.03755622,-0.053579833,0.113364995,-0.09605584,-0.03634399,0.022560894,0.014008458,-0.01733133,0.015362796,0.07104742,0.052323185,0.0076136356,-0.033560365,0.03733401,-0.046719898,0.031668022,-0.09381976,-0.03085987,0.03439471,0.11370522,-0.013407211,0.03270787,0.01591743,0.012544419,-0.0033986382,-0.002823152,-0.026383627,-0.0063336114,0.013034072,0.006284352,-0.009211488,-0.05994513,-0.022588655,0.01563675,-0.035725974,0.009713101,0.03504734,-0.033484302,-0.053159676,0.08036772,0.11415689,-0.08615465,-0.030724414,-0.022131829,0.01298558,-3.0600818e-33,0.11844169,-0.047730863,0.06531446,-0.1488831,-0.06584321,0.053041194,0.017444033,0.0042191646,0.021875063,-0.027269438,0.08108076,0.016511805,0.014199903,8.2735e-05,0.008151981,0.013649449,-0.013993383,0.012638492,0.011842649,-0.00696229,0.111176305,0.057773173,0.061155673,0.03656457,-0.020448683,-0.016767412,-0.045708526,0.012509159,0.023430273,0.09034197,-0.045286458,-0.022235839,-0.03487563,0.012288112,1.4002273e-05,0.0073247044,-0.032539606,-0.014926032,0.0175357,0.018624684,-0.01540617,0.04211818,-0.011061183,0.06823323,0.015357741,0.047207043,-0.08775825,-0.026243778,-0.004021651,-0.11008165,0.013496362,0.057378057,-0.043762777,0.056755126,0.009244929,0.010207378,-0.011517939,0.030269984,0.01911004,-0.038354393,-0.05795175,-0.054270405,0.017414665,-0.013264475,0.05582642,0.07832731,-0.03177675,0.055833627,0.04149758,-0.010696916,0.022038503,-0.021511197,-0.013875719,0.027886294,-0.004431485,-0.06011369,-0.09333785,-0.0026478516,0.010984273,-0.0054371324,-0.028516078,-0.036690615,-0.07577754,-0.06396584,-0.021192087,-0.06865234,0.07005638,0.114453316,-0.024556082,0.063526444,-0.009653538,0.068647146,-0.046489447,0.073283955,0.020733513,-4.01203e-08,-0.0006585464,-0.060417168,0.018665098,-0.040065203,0.034362536,0.089848675,0.039849084,0.010465061,0.09335304,0.044331815,-0.028201414,0.08577143,0.03968396,0.045077894,0.05303586,0.033881247,-0.0649895,0.035364922,0.0043793847,-0.06866799,-0.04304422,-0.001181891,-0.034677815,-0.005417994,0.0312126,-0.030606704,0.010840908,-0.013519927,0.0154732475,-0.023345187,-0.056173474,0.014026786,-0.004257141,-0.057219937,-0.07174437,0.07736054,-0.10000557,0.0072506424,-0.06320405,0.04664662,-0.057028707,-0.060222987,-0.04865821,0.039566703,0.027353812,0.036162402,0.03983101,0.038373113,-0.043023914,-0.039248984,-0.03188904,-0.02315561,-0.037822224,-0.047325317,-0.08962938,-0.026586026,-0.0118460255,-0.01075831,-0.019745689,-0.050565995,-0.0021216874,0.02922708,0.14237188,-0.05544329 +3.13.2.2,"Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC 3.13.2.3, (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming).",384,0.99999994,-0.030188467,-0.050978985,-0.04862914,0.016073857,-0.019480469,0.041726228,-0.06448751,0.021095384,0.049144857,-0.006827784,0.0059431926,-0.004131777,-0.03743142,0.052751828,-0.045093086,0.01220157,-0.105577424,-0.00020084482,0.020254841,-0.036417194,0.05789233,0.04228802,-0.043351214,0.07186615,0.08142351,0.061824776,0.034011573,0.06294547,-0.0077064936,-0.007471658,0.006294657,-0.07197785,0.059344184,-0.022534091,0.09046421,0.089607075,-0.027464751,0.024592109,0.031214379,-0.008263659,0.055615656,-0.05171335,0.0678686,-0.007660979,-0.03550581,-0.034211367,-0.08141431,-0.016501583,0.014481348,-0.014412957,-0.011882726,-0.07175923,-0.06619449,0.0449125,0.08712653,0.0131993415,-0.0856447,0.0340756,-0.008315354,-0.020479571,0.018086325,-0.025383001,-0.020190367,-0.017248124,0.0096594095,-0.041726477,0.024044722,-0.051819712,0.07291993,0.014716738,-0.052646957,-0.0272648,0.024998367,0.034075413,-0.03622776,-0.034119587,-0.017937113,-0.031162629,0.040583283,-0.06832679,0.057144165,0.040451027,0.0042985594,0.074440636,-0.005092945,0.01436816,-0.024402773,-0.01586114,0.07762728,-0.09248167,-0.062878616,-0.052453108,-0.04331606,-0.054315094,-0.021885132,-0.005545767,0.040069863,0.025935344,-0.06711611,-0.017380452,0.049793202,0.037259147,-0.113520995,-0.10800327,-0.034485478,0.05599021,0.008531029,0.12383285,0.027093291,0.01573887,0.016050583,0.03629952,0.028669048,-0.01995322,-0.030251112,0.034266245,-0.0040676706,-0.012448879,0.0131045915,-0.030789329,-0.02582111,-0.044412695,0.058929496,0.0129584875,-0.027969241,-0.011570834,-0.03327984,-2.8620645e-34,0.11141248,0.034989867,0.04225798,0.01816609,-0.026069166,-0.047944862,-0.062279295,0.027383555,-0.012410451,-0.051995426,-0.050051216,-0.021588746,-0.00010598911,0.00027168848,-0.062023018,-0.013498917,-0.03652484,0.027155695,0.030127008,-0.010593266,-0.08031371,0.04907061,-0.008814058,0.0011978179,0.016384955,-0.057661906,0.0057427357,-0.007384527,0.089281395,0.0019337357,-0.013396592,0.0003153536,-0.06417397,0.044246953,0.009014949,0.06322895,-0.16060847,-0.039375,0.10466603,0.10535801,0.0036994366,-0.032554127,0.04814079,-0.09789939,0.005459334,0.030935103,-0.06168715,0.07580886,0.011237947,0.04401262,0.023474386,-0.02878829,0.06516165,-0.022220632,-0.095315844,-0.035283923,0.0066603147,-0.036350086,0.041503455,0.10140673,-0.0056411577,0.028720243,-0.015985113,-0.021787,-0.06288059,0.012652649,-0.076566845,-5.732873e-05,0.0003081958,0.080899514,-0.0081331795,-0.0069196164,0.0757158,0.034530215,0.018297978,-0.037298482,0.037054986,0.034695286,-0.0004059444,0.08602542,0.023143904,-0.037446316,-0.0055542206,-0.014000535,-0.07965274,0.025136096,0.011053995,-0.06798805,-0.032858066,0.06532093,-0.044057585,-0.052342873,-0.015839636,0.0039447797,-0.027481338,-1.3348451e-33,0.042469837,-0.064951956,-0.017404241,-0.08275002,-0.042367782,0.0114683295,0.07158743,-0.068377584,0.024627917,-0.02425818,0.12905984,0.0105077615,-0.054256134,-0.087590925,0.029926803,-0.00327806,0.012654403,0.044217385,0.050280776,0.012796351,0.038936052,0.07081371,-0.073802546,0.07773231,0.13219841,-0.040563963,0.003618326,0.032919258,0.07504074,0.06865833,-0.011275334,-0.04888767,-0.054798197,-0.0001987255,-0.05176856,0.05302541,-0.0054305457,-0.014867802,-0.027807407,-0.021177603,0.010243381,0.040478848,0.06373364,0.14668481,0.0820549,0.071789116,-0.062281653,0.020594126,-0.03809477,-0.06542076,-0.020657899,-0.094531424,-0.029961085,0.021514308,-0.024450233,0.11482433,-0.046680942,0.024786228,-0.014232461,-0.08946247,-0.059966397,-0.08852018,-0.03237663,-0.0555912,-0.033007964,0.038434528,-0.06864224,-0.007778065,0.025786065,-0.007496801,0.019094408,-0.069592096,0.035964023,0.048975274,-0.04555319,-0.06699345,-0.059977762,-0.014270358,-0.011769501,-0.03809782,0.05534435,0.054312877,-0.009777948,-0.0022326463,0.02676847,-0.017578017,0.066690534,0.101829045,-0.053034686,0.0629444,-0.027761098,0.04323874,-0.035573028,0.08692099,0.04457765,-3.5333798e-08,0.05146091,-0.124448895,0.05247812,-0.044724196,0.02048389,0.06789275,0.07306928,0.053428683,0.055751577,-0.017260622,-0.061912358,0.043916892,0.02130261,-0.028790014,-0.014144469,0.012774616,-0.035602033,0.06743628,-0.058771465,-0.05378988,-0.098023355,-0.01254754,-0.08886179,0.041114226,-0.016119696,0.0038839686,0.051221203,0.059649073,-0.054968707,-0.013363764,0.06983162,-0.040075187,0.0038228924,-0.050337613,0.0077265673,0.026972376,-0.040416162,-0.007555863,-0.0032405783,-0.061194208,0.0022330678,0.01681829,0.02818989,0.08741747,0.058948707,-0.0024207665,-0.033002567,0.08586601,-0.036676195,0.019029662,0.08485375,-0.008912793,0.009921754,-0.08006852,-0.039139647,-0.021330122,-0.009388644,-0.07128026,-0.0083223535,-0.048022673,0.04627786,0.057629433,0.21080567,-0.00442496 +3.13.2.3,"The enzyme, found in bacteria and archaea, is involved in removing the (R) isomer of S-adenosyl-L-methionine from the cell. It catalyses a nucleophilic attack of water at the C5' carbon of S-adenosyl-L-methionine to generate adenosine and L-methionine.",384,1.0,-0.0770199,0.014895115,-0.006459533,0.059140436,0.08695151,0.06698197,-0.08428272,-0.009172295,0.04832377,0.05793702,-0.023043562,-0.047129724,-0.02591315,0.04900454,-0.079748586,0.038038675,-0.121560454,0.014959178,0.0029912384,-0.07537462,0.017861053,0.07356916,-0.054700106,0.033207912,0.11493098,0.0071090395,0.046161197,0.010373798,-0.05698538,-0.02907714,0.02228748,-0.06209635,0.10923178,-0.04373315,0.0441875,0.13142191,-0.06248205,-0.006101219,0.10680047,-0.019779885,0.026832271,-0.044204555,0.044926804,-0.0007032826,-0.0067232396,0.0052588214,-0.04610153,0.042497065,0.032170482,-0.034746036,-0.008837265,-0.07162902,-0.088234656,-0.020404471,0.017050825,0.024801735,-0.036313325,-0.04773663,0.03306026,-0.041459687,0.08053816,-0.042867966,-0.011179128,0.043323252,0.06471182,-0.11718629,0.03647105,-0.043650273,0.089905985,0.00115398,-0.024766736,-0.049192,0.0006098685,-0.014692925,-0.022498587,-0.058439955,-0.031348985,-0.046664808,0.059208512,0.0082048895,0.076798014,0.0058734994,0.042323157,0.06280276,0.024593432,0.048213396,0.015684735,-0.059365097,0.071268074,-0.055940215,-0.02469523,-0.020793285,-0.012073195,-0.08720363,-0.041133806,-0.015027522,0.02525085,0.016547838,-0.044258285,0.018878715,0.04012797,0.067552745,-0.10718372,-0.106064916,-0.027169405,-0.020863142,-0.0061476035,0.07181668,0.013036193,-0.0067040836,0.012815203,0.012457423,0.012920709,0.00477662,0.0040937676,0.09157761,0.08001587,-0.05554681,-0.07390535,0.03580871,-0.0634756,-0.08664823,0.014616593,0.043605372,-0.03821402,0.034244552,-0.06014186,9.445967e-34,0.07244474,-0.008688961,-0.023247998,0.00079552684,0.07414372,-0.052165788,-0.045030497,0.0045004855,-0.03020498,-0.021278992,-0.09104819,-0.053171,0.057574946,-0.03504675,-0.056494795,0.024074612,-0.045140374,-0.008402222,-0.00986439,-0.030040689,-0.066474445,0.005570125,-0.005509419,0.022529626,0.019852553,0.02170323,0.0030653246,-0.011815244,0.08738282,-0.010043914,-0.0247375,0.04727387,-0.10879515,0.053700037,0.059893098,0.040621784,-0.08844601,-0.042685308,0.03012603,0.10515844,0.002966114,0.052330874,-0.026998557,-0.073826216,0.048245996,-0.012363752,-0.044428077,0.09558591,0.030622413,0.082917914,0.061195217,-0.040709153,0.07374289,-0.025297925,-0.10868361,-0.01707656,0.0166457,-0.07183176,0.011236625,0.07527624,0.0073704524,0.037798204,0.0025206327,0.032407325,-0.020271413,0.03974596,-0.049143128,-0.03866057,0.06543066,0.062075168,-0.043532632,0.0060978886,0.0502715,0.057798665,-0.021730833,0.0071333474,-0.06344479,0.016685251,-0.0036288535,0.015797717,0.008339092,-0.039311834,0.04553539,-0.0017427184,-0.030973813,-0.02011278,-0.020921428,-0.08149245,0.008618026,0.04250228,0.077816434,-0.10155313,-0.039842658,0.003890366,0.00019907841,-2.5057378e-33,0.06305317,-0.11452895,-0.012391738,-0.0912644,-0.03484685,0.02342976,-0.037015185,-0.0853736,0.03464228,0.005397749,0.08391014,0.01426754,0.01640056,-0.0061601093,0.07302192,-0.060698576,0.067257114,0.024497984,-0.03894298,0.018082136,0.06867003,0.001928793,0.014450536,0.00089886534,0.053439118,0.010377409,-0.013993715,0.02409928,0.06882483,0.035005856,-0.057214104,-0.0019092449,-0.012014988,-0.014817687,-0.009255293,0.10485495,-0.0016564246,0.06962174,0.010566966,-0.025590295,0.039081484,0.056225725,0.0034203308,0.099813096,0.048123393,0.04514108,-0.035572153,0.018181322,-0.04344168,-0.1384113,0.035946455,-0.07598187,0.00932449,-0.02946205,-0.034322288,0.112247765,-0.008817007,-0.00242687,-0.028099045,-0.042417824,-0.041613188,-0.05999821,-0.021188019,0.0036524585,0.016761389,0.031778894,-0.023977408,0.048891444,-0.02508607,-0.06764841,0.023871709,0.008656064,0.07030202,0.04670007,-0.07233354,-0.045103893,-0.056869783,-0.02955673,0.010008024,-0.04332721,-0.015911212,0.029725801,-0.0075178244,-0.059422117,0.00014646824,-0.0761247,0.05507453,0.09074515,-0.002703579,0.044861116,-0.031658985,0.024469899,-0.043025784,0.020433925,0.074845195,-3.7034074e-08,0.07343969,-0.11570734,0.05066104,-0.043945644,0.033479597,0.114547,0.031958006,0.05258627,0.0736672,-0.051353432,-0.048220538,0.11261804,0.025301564,-0.008443875,-0.008409725,0.061750337,-0.0285592,0.0059905155,-0.042367216,-0.050445087,-0.10686602,-0.02727993,-0.06543053,0.025323104,0.011817288,-0.03179565,0.03448047,0.09544027,-0.059887838,-0.04874571,0.027915686,-0.020968065,0.0058870595,0.020849342,-0.055622164,0.014417586,-0.039816372,-0.060234353,-0.03466319,-0.006892617,0.0039551947,0.06796106,-0.074842155,0.032996405,-0.0115127135,0.012415631,-0.031138806,-0.0042943503,-0.037727237,0.034413822,0.06458452,-0.012261904,-0.037498463,-0.0112111345,-0.059087083,-0.057858717,0.006167711,-0.06391002,-0.04569998,-0.012506587,0.019066686,0.028247874,0.17044644,-0.037372127 +4.1.1.122,"Requires pyridoxal 5'-phosphate. The enzyme, characterized from chicken, is specific for L-cysteate and has poor activity with 3-sulfino-L-alanine. cf. EC 4.1.1.29, sulfinoalanine decarboxylase.",384,0.99999994,-0.0064665764,-0.11376902,-0.04567626,-0.08623695,0.014611587,0.052254956,-0.049475197,0.02820337,0.052390795,0.010826104,-0.0155190015,-0.019147113,-0.11457203,0.096079305,-0.06485734,0.02851404,-0.024298504,-0.010257879,0.008840041,-0.050581124,0.06966872,-0.009530735,0.0100492975,0.006405197,0.014703896,0.018330628,0.011673681,0.028307255,-0.032191824,-0.04752559,0.0011827416,-0.030485462,0.0098215975,-0.019912068,0.042538572,0.083678596,-0.09345957,-0.030945368,0.06661351,0.047291324,0.06605018,-0.06490023,0.010435942,-0.012311589,-0.020064894,-0.014212597,0.0018774426,0.0009390576,0.01408364,-0.07580463,-0.079844594,-0.031573784,-0.00695236,-0.002953358,-0.074313484,0.014738396,-0.05302493,0.046335425,-0.06646922,-0.08373251,-0.05566942,0.05586888,-0.019571826,-0.024142502,-0.006825671,-0.0065451325,-0.023012256,-0.074769065,-0.005977211,0.05334253,-0.05506004,-0.10131627,0.0017332954,0.031617183,-0.060309302,0.07683581,0.004833436,-0.05684074,0.010229344,-0.04444891,0.0051712254,-0.034697443,-0.053356644,0.07307855,0.0743225,0.0055006356,-0.018459173,0.003122557,0.019654565,-0.03501821,0.11756616,0.0070909616,-0.050429653,0.024659155,0.07737604,0.045914274,0.031107347,-0.026785403,-0.038027935,-0.04260264,-6.2228886e-05,0.03837546,-0.064618915,-0.038294483,-0.0661534,0.02024172,0.012083191,0.013557531,-0.023256082,-0.023034235,-0.08812973,0.0006089524,0.0037788108,0.027820809,0.034638356,0.07794875,0.03403829,-0.0641441,-0.040911432,0.014584893,0.028528411,-0.056730352,0.042753194,0.09898995,-0.020800265,0.09045191,-0.13819227,1.5322524e-33,0.086566076,0.054790713,0.08328885,0.01433407,-0.0002757306,0.033557497,-0.07412135,0.00073407154,-0.014123682,-0.014436924,-0.035159856,-0.058896944,0.0047533666,-0.06396473,0.0025848167,0.039347786,-0.008867925,0.016876759,0.06359716,-0.019251307,0.045499917,0.0057242108,-0.03982578,0.045010254,-0.0028683825,0.06784252,0.04508917,-0.024159897,0.027086416,-0.00898572,-0.011558076,-0.13270396,-0.048785668,-0.008408157,0.052181784,-0.0033927488,-0.034918014,-0.07816225,0.008428514,0.07585863,0.018244082,-0.06133411,0.091393314,0.009145501,0.03402409,-0.079914145,-0.065431185,0.056066334,-0.029840922,0.049967676,0.10878401,-0.049363792,0.039920926,-0.04019089,-0.049841177,0.000269773,-0.049791098,0.017558053,0.04387635,0.044323336,0.0048970627,-0.007655298,-0.04367523,-0.010490887,0.05651951,-0.041812684,-0.09007479,-0.048061524,-0.04913983,0.11692186,-0.041226156,-0.120089374,0.09199757,-0.0020439443,0.0768949,-0.00043090282,-0.061805483,0.06388865,0.08360123,-0.017268715,-0.006775953,-0.022256419,-0.056614067,0.008364226,-0.05212685,-0.052565064,0.024299355,-0.017416397,0.031551845,0.060813278,0.030709041,-0.098947406,-0.026858788,0.038916882,3.9124167e-05,-2.427419e-33,0.029206652,-0.053424947,0.04568397,-0.0062892414,-0.026005223,-0.0008229713,0.05888407,-0.051149268,0.12159124,-0.037527774,0.04401771,-0.040515352,0.030855391,-0.038766824,-0.023952514,0.06536511,-0.00035027042,0.045441736,0.072352104,-0.0034769762,-0.01041181,0.06153229,0.015090856,0.087992236,0.09441088,0.05390038,0.012237189,0.058160912,0.008993142,-0.033703398,-0.0328672,0.05814806,0.0062374687,-0.11456292,-0.07058679,0.06119678,-0.081934325,0.003296109,0.012050417,0.02245916,-0.040485032,0.024785757,0.036314066,0.08091424,0.015696215,0.010707163,-0.016373318,-0.057946093,0.063796334,-0.010934876,0.016153706,-0.032706566,-0.012264432,0.0021476625,0.093578875,0.0925688,-0.046046034,0.0367029,0.011668,-0.00055779814,0.0034436625,-0.0075029423,-0.013542141,-0.019182142,0.048652872,0.03557958,-0.01808367,0.022405252,0.08634708,-0.0023757804,0.056735303,0.05366867,0.07128999,0.065402836,-0.06779073,-0.0014479082,-0.059515353,0.044239823,0.06618292,-0.04551283,-0.03733907,-0.011362136,-0.032697868,-0.0939597,0.004535483,-0.111681476,0.036318194,0.1339205,0.016193377,-0.008541421,0.0064601903,-0.0660863,0.021702925,0.0920547,0.08221215,-4.0420023e-08,0.04067992,-0.077970624,-0.018459301,-0.062499028,0.058773726,0.0063540232,0.043894086,-0.056796256,0.06790044,-0.0037038606,-0.011950334,-0.009743317,0.011971367,0.035961337,0.06330271,0.050017856,-0.03282357,0.04785299,-0.015137979,0.033318877,-0.05693813,0.0118548395,-0.14620973,-0.008488233,0.075130686,-0.050156366,0.045079134,0.05738823,-0.011296138,0.026354652,0.01585248,0.023334334,0.07263179,-0.04129457,-0.066679165,0.061610613,-0.048233576,-0.029173944,0.005000459,-0.015785987,-0.029709361,0.005720096,-0.039903075,-0.01728185,-0.019283613,-0.025818922,-0.06341795,-0.0076318127,-0.043203227,-0.028846992,0.037540555,-0.047051538,-0.018428925,-0.075870514,-0.027429143,0.05756628,0.046044376,-0.053618245,0.044255227,-0.107336186,-0.017441688,0.026897324,0.16823465,-0.04821567 +4.1.1.123,"The enzyme, characterized from the bacterium Thauera aromatica, participates in an anaerobic phenol degradation pathway. It catalyses the para dephosphorylation and carboxylation of phenylphosphate to 4-hydroxybenzoate. The enzyme from Thauera aromatica consists of four different subunits and requires K+ and a divalent metal cation (Mg2+ or Mn2+) for activity. It is strongly inhibited by oxygen.",384,1.0,-0.026486356,-0.0037077342,-0.095507726,-0.016182965,0.036934756,0.03611102,0.0059826476,0.004576373,0.07472198,-0.009231787,0.0017894125,-0.019975834,-0.028770126,0.009906814,-0.07567171,0.06962631,-0.02867076,0.06068442,-0.04995162,-0.044354882,0.070444755,0.002901172,-0.020248977,0.00023345156,-0.01325373,-0.04289364,0.08365203,-0.04054825,-0.082314625,-0.015076626,0.036017146,0.008765694,0.04520221,-0.053003572,0.08746313,0.14286633,-0.012044334,-0.107192576,0.014105882,0.033185896,0.010713664,0.0060358252,-0.009700055,-0.06773407,-0.011749411,-0.034335226,0.019797299,0.049325526,0.039036795,-0.062858015,-0.060802534,0.012718492,-0.06459052,0.06780846,-0.02219082,0.04342382,-0.06154618,0.0014372262,-0.09512541,0.042196244,-0.021599235,0.009457631,0.034586634,0.015386977,0.008578698,-0.07471643,0.033191655,-0.035380423,0.05283372,-0.018296767,-0.11033295,-0.11151241,0.0005691187,-0.055749703,-0.021788644,-0.017905591,-0.00155158,-0.019656459,0.06313173,-0.07756047,0.035029765,-0.0101844845,0.056904346,0.037152965,0.06446125,0.015092361,-0.016522512,-0.033582974,0.1238926,0.0851641,0.06297614,0.07074547,0.036649138,-0.035106268,-0.06791357,0.04029762,0.082793236,0.03800322,0.014343732,0.012136248,0.063636445,0.04239378,-0.028121969,-0.09687065,-0.03156776,-0.0011180975,0.04419661,0.10492926,0.030709043,-0.0069998386,-0.010191658,0.014669545,0.032586988,0.012378815,0.015513298,0.060448714,0.030687835,-0.07249155,-0.08749385,-0.020125784,-0.04879955,-0.06439291,0.02523994,0.012893792,-0.036940064,0.013200312,-0.12495213,5.1207583e-33,0.109871954,0.0063230935,0.021167248,-0.01477413,-0.029394345,0.007000069,-0.04955149,0.028893253,-0.04545301,-0.08003808,-0.0383807,-0.09159633,-0.0008432882,-0.061393224,-0.003309993,-0.052264746,-0.08850929,0.049430247,0.10137366,0.053000443,0.023083678,0.014424686,-0.035521172,-0.0049572797,0.040878646,0.08961597,0.0096057905,-0.036843155,-0.045887016,0.011118604,0.03477348,-0.10338311,-0.13485709,-0.03158066,0.027785836,-0.03638609,-0.063191995,0.009880839,-0.030893726,0.033575065,-0.049856678,-0.0007225428,0.0024769092,-0.019957269,-0.0043985485,-0.015929727,0.0030222824,0.09811519,0.03844673,0.050703313,0.05508133,-0.036813598,0.1327772,-0.013119122,-0.09589714,0.07150044,-0.009355012,-0.010512454,0.0791704,-0.024724705,0.018895619,-0.00029553715,-0.07459144,0.048571564,0.06161836,-0.035779394,-0.10390002,-0.03194489,0.028003216,0.11870034,-0.069212966,-0.05555631,0.06855258,0.017567202,0.036268912,-0.04234456,-0.097060524,-0.023455536,0.018610917,0.07462599,0.023287166,-0.046911392,0.013632921,-0.057836615,-0.03429943,-0.014405747,0.024591789,-0.016804837,-0.008715635,0.0011091523,0.048860326,-0.10274447,-0.05554213,0.0041049747,0.054810483,-5.323224e-33,0.1317377,-0.055098217,0.018110001,-0.039380543,0.00764426,-0.023793101,-0.008108725,-0.00028374634,-0.018700218,-0.004498892,0.069971,-0.03853566,0.033443063,0.010070339,0.014907761,-0.02699594,0.015484826,0.032753468,-0.008645895,-0.036976106,-0.026961908,-0.0010840705,0.009454751,-0.019168584,-0.021509407,0.008152832,-0.028467711,0.04997951,0.04135254,0.03895334,0.010368766,0.060953762,-0.031698868,-0.010981989,-0.05338726,0.07199458,-0.10058611,-0.006258342,0.02138157,0.049161404,0.07267431,-0.033679616,0.03937988,0.08078796,0.03007856,0.05865586,-0.09927626,0.022545975,0.007325001,-0.059374027,0.042339582,0.033802576,-0.057536747,0.012097199,0.074530676,0.0546103,-0.027149456,-0.025705699,-0.015503749,-0.017887834,-0.033272453,-0.031244684,0.060599867,0.038223136,0.0111801345,0.045277726,0.0019861609,0.07942382,0.03301291,-0.012907827,0.1401841,0.07453009,-0.00044275896,0.06853151,-0.058710687,-0.08149676,-0.05439219,0.006806274,0.014806366,-0.043557413,0.028365081,-0.05040453,0.004881443,-0.109113425,-0.019508077,-0.105517976,0.03180136,0.075093836,-0.0405562,0.024569215,0.029438624,-0.047131937,-0.06074517,0.087179035,-0.010599197,-4.1671544e-08,-0.067912795,-0.06864291,0.034483675,-0.052893456,0.006707611,0.04588171,0.0403058,0.03853467,0.082191534,-0.046045512,0.04774193,0.0029421682,0.0017452885,0.029557195,0.057529744,0.04153422,-0.090966925,0.0051595066,-0.03963386,-0.036054876,0.026204817,-0.02946647,-0.13486136,0.09111532,0.0427349,0.007778531,-0.0008242133,0.060689107,0.00418918,-0.049732443,-0.03215096,0.046921447,0.034165997,0.017791688,-0.066175014,-0.013704601,-0.054572448,-0.03911488,-0.044501234,0.013370934,-0.03816935,-0.01763701,-0.08547432,-0.011027673,0.05927131,0.014763715,-0.0011946681,0.0275927,-0.012825066,0.027414335,0.040075574,-0.038237583,-0.02449815,-0.007554066,-0.08536062,0.0154722,0.031409714,-0.021120664,-0.012522424,-0.048596103,0.022165617,0.0043382687,0.12758689,-0.045725107 +4.6.1.26,"The enzyme, found in bacteria and archaea, forms cUMP, which functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.",384,1.0,-0.09395154,-0.023198428,-0.019516688,-0.026231417,0.0019724772,0.058073483,-0.037643604,0.086359836,0.07267752,0.028810276,-0.0020310287,-0.025540365,-0.046051998,0.069267005,-0.03916038,0.039130345,0.016115058,-0.003279857,0.038445037,-0.115193196,-0.004551871,0.076504685,-0.041106742,-0.04853522,0.018577386,0.021463208,0.0393784,0.035781942,0.005546418,-0.025650805,0.0242321,-0.023302726,0.050506588,-0.06513934,-0.03978671,0.06487136,-0.047213655,-0.061459586,0.00804204,-0.07967799,0.048990827,0.025162611,-0.020021752,-0.00030474825,0.009180282,0.055423927,0.015602241,0.09851191,0.096743524,-0.04901332,-0.04510589,-0.0015204159,-0.015930047,0.03288498,-0.040146314,0.0009495956,-0.08442291,-0.0862876,-0.040121645,-0.0063395426,-0.055863056,0.06608531,0.073584095,0.018121887,0.07356894,-0.021044292,-0.012120364,0.047157697,-0.04040979,-0.016259247,-0.09421406,-0.05412742,-0.060485188,0.054065417,0.010269124,0.006963195,0.023316981,-0.039523076,0.061254833,-0.00938223,0.02274679,0.049795832,0.03561043,0.1236817,-0.008956652,-0.04294044,0.07725062,-0.0024696714,0.020495307,-0.047846355,-0.0015365517,-0.042511538,-0.011613681,-0.020609275,-0.035250835,0.05555263,-0.044514738,-0.029805832,0.012772356,0.0070597474,-0.09296349,-0.030085845,0.022246523,-0.12873937,-0.048869204,-0.029693604,-0.034645665,0.06059132,0.09595419,-0.0075986506,0.01588951,-0.037090044,0.0019426383,-0.042637464,0.09840091,0.049878933,0.00061047246,-0.019270612,-0.070425615,-0.04369558,-0.0047866353,-0.08367761,0.011598067,0.055707328,-0.026908662,0.0035447667,-0.0007610556,-1.4063772e-33,0.03990664,-0.05540974,0.017112179,0.023871418,0.06829594,0.01651837,0.02773608,0.00033681883,-0.026697597,-0.021866728,-0.002339703,-0.11836686,-0.0068162926,0.06701362,0.008840049,-0.024173034,-0.03491803,-0.034164023,0.040975254,0.00011319799,0.038484,0.043301217,0.037562523,-0.022895824,0.017319169,0.0764995,-0.054214746,0.04902814,0.06630808,-0.027986282,0.015929138,0.028827881,-0.14764866,0.025348887,0.017766159,0.029012382,-0.062975004,-0.08964683,-0.011150081,0.04938467,0.051625762,0.025586307,0.007931831,-0.010194177,0.043135915,-0.08553666,-0.11002443,0.041251846,0.105836265,-0.022196691,0.08277171,-0.012683687,0.08199416,-0.050109558,-0.04876922,0.034226775,-0.06279193,0.033763245,-0.0005581368,-0.009574631,-0.022427116,-0.0029873906,-0.009199049,0.061040174,-0.03460087,0.039839897,0.037779644,-0.039258767,0.05650503,0.12878911,-0.022565423,-0.005065553,0.027569318,-0.013765112,-0.032747805,-0.0786682,-0.053001963,0.0031523074,0.09677583,0.038929515,-0.065504365,-0.10536666,0.001118593,0.05390864,-0.018287638,-0.010291535,-0.009133817,0.0017984478,0.06763652,0.0012342263,0.06356118,-0.0039940677,0.015213291,0.09763494,-0.034959115,-1.002221e-33,0.07253197,-0.09425518,-0.0008066477,-0.011460574,-0.0533839,0.06924616,0.07286653,-0.065574475,-0.03654887,0.030160977,0.09600976,-0.01586822,0.0600639,-0.033567484,0.10585855,0.031180654,0.07450457,0.038386837,-0.05052433,0.007825904,-0.013148517,0.042787846,0.025721684,-0.038711987,0.09216366,-0.012441021,-0.03186873,0.060506694,0.023983436,0.031927478,-0.0020042523,0.105137765,-0.08182517,-0.039685216,-0.0063893436,-0.0023640497,0.03113722,-0.0073274965,-0.023835873,-0.06840844,0.03687512,0.046944875,-0.0006157134,0.11707204,0.013728449,0.12996563,-0.0075851376,0.08752528,0.031408653,-0.055113275,0.033078562,0.01717938,-0.015599293,0.025322007,-0.05398208,0.09543203,-0.048608676,-0.025835695,0.06500338,-0.061254963,-0.08932486,-0.15020727,0.056354403,-0.02563358,0.009802458,-0.0016939663,-0.025093418,0.018811889,0.012957442,-0.085643165,0.051873304,-0.0034259064,0.07452505,-0.067823045,-0.052819867,0.008056351,-0.042061277,-0.06614709,0.055115256,-0.0011222474,-0.013845638,-0.022932038,-0.051363233,-0.040519953,-0.047667105,-0.07553134,-0.024844972,0.09867556,0.030244725,0.02246316,-0.06924364,0.0072735557,-0.047227938,-0.027277425,0.04516532,-2.9648037e-08,0.044498377,-0.04232915,0.022191761,-0.077404216,0.018903736,0.029953448,-0.077805,0.011431398,0.0580324,0.0019066111,0.04172939,0.0149483895,-0.009569447,-0.05178872,0.03696851,0.029969845,0.024616206,0.026184577,-0.060829904,-0.092681736,-0.04122904,-0.005593478,-0.07821482,0.033122208,-0.01392953,0.0058471863,-0.035167776,-0.03975133,-0.016531937,-0.09904389,-0.04961558,0.09201856,0.03162658,0.008086369,-0.029345663,0.07216915,0.057801694,-0.052643977,0.015537936,0.018294297,0.051055137,-0.033972356,-0.032031093,-0.045055535,-0.036528513,0.058254536,0.03394987,0.013018599,-0.08810068,-0.010728649,0.007212213,-0.01911369,0.002860048,0.009747866,-0.03302845,-0.031283822,-0.02479455,-0.13459817,-0.003939626,0.01325679,-0.021875467,0.013517564,0.12532069,-0.060754746 +5.3.1.37,"The enzyme, characterized from the bacterium Clostridium sp. MSTE9, is involved in a D-sulfoquinovose degradation pathway.",384,1.0,-0.0723957,-0.06279624,-0.05273687,-0.022766592,0.07309618,0.0021939997,-0.028074162,0.086455464,0.018060254,-0.023612697,-0.021854805,0.033336055,-0.030690156,0.11368912,-0.062454555,0.07491817,-0.070165776,0.0027201255,0.039700467,0.046634585,0.09521722,0.08692536,-0.025576603,0.009352123,0.08134263,0.020166218,0.061998136,0.012071088,-0.08137448,0.011625277,0.043012857,-0.037130676,0.016123293,0.005376454,0.07375595,0.09256179,0.027828703,-0.013172412,0.07667212,-0.043831,-0.00078718713,0.033616986,-0.009233758,-0.020376595,-0.01535289,0.065053105,-0.04973634,0.04285152,0.009079289,-0.045043293,-0.05990249,-0.09210162,-0.03377691,0.030923273,0.07183651,0.011270823,0.017724352,0.017794635,-0.019903338,-0.0448416,0.025276206,0.024453463,0.04238421,0.024148673,0.04529568,-0.032049302,0.047079712,-0.053387146,0.013811032,-0.027008604,-0.08777278,-0.04726138,-0.031455964,-0.039574046,0.00038202552,0.09146277,-0.033787236,-0.061489947,0.0034457138,-0.06919047,0.051641732,0.027501713,0.07075707,0.049081624,0.020360932,-0.012479215,0.07753016,-0.06788772,0.098047905,-0.0073857484,0.011541458,-0.0066545648,-0.036056444,-0.078806914,-0.06272836,0.009180897,-0.032402106,0.06558176,0.010322756,0.0030467042,-0.024049444,0.049545746,-0.061649807,-0.09617666,-0.06351911,-0.0354613,0.064053476,0.10257161,0.008068343,-0.07869733,0.0031862797,0.021875428,0.056421377,0.038891792,-0.0012411143,0.008705795,0.07255032,0.0022830376,-0.101782486,0.046811752,-0.050461963,0.0038863225,0.010410214,-0.018220956,-0.008743399,0.10851056,-0.06742605,-1.460707e-33,0.08630577,0.015961105,0.02311629,-0.05358077,-0.0044263597,-0.02028605,-0.116267554,0.017979328,-0.0126353055,-0.01341785,-0.055247538,-0.14479375,0.0054174773,-0.012197556,-0.0030427761,0.010783292,0.0033467526,0.036606643,0.054573655,-0.04748297,0.016072724,0.04488886,-0.01789358,-0.03932333,0.056045935,0.06910423,0.008803871,0.058025163,0.0026660645,-0.019717352,-0.004049892,-0.09046776,-0.10079585,-0.04257644,0.04929645,-0.0056637432,-0.040797096,-0.054957595,0.014718473,0.009534478,-0.0051383283,-0.0066718366,0.010545652,-0.05173844,0.010095871,-0.047972403,-0.025906147,0.11700331,0.02872309,0.060765505,-0.0033259226,-0.0733768,0.07325299,-0.039632365,-0.062113516,-0.005876456,0.0018978075,-0.018729035,0.07839445,-0.0029253613,0.034517646,0.03190525,-0.08345681,-0.041574724,0.064659595,-0.06536402,-0.0029415982,0.016991181,0.02817831,0.039265264,-0.02691862,-0.07206563,-0.003701889,-0.0003841098,-0.004494054,-0.04734099,-0.021085024,-0.02901016,0.08495701,-0.0014923486,-0.07424513,-0.05661087,-0.027907183,-0.04674419,-0.045929074,0.01632931,-0.046481192,-0.060775224,-0.06306787,0.028354503,-0.008562173,-0.09117742,-0.104365736,0.03991706,-0.0010432875,-4.3449435e-34,0.051909696,-0.023032222,0.048570808,-0.0399196,-0.07729839,0.054236017,-0.041429292,0.051875044,-0.00995946,-0.06119386,0.006163951,-0.0072972802,0.061802186,-0.07826755,-0.0046332777,0.03802033,0.011627576,-0.029304193,0.011283578,0.006655473,0.024943536,0.136059,0.0036331415,0.040498637,0.040996727,0.046677604,0.012309187,0.12037957,0.08193511,0.07376032,0.022122394,0.054273643,-0.010115977,-0.021249687,-0.056268625,0.05838206,0.003378462,0.0026728744,0.04002614,-0.006499016,0.06520872,0.019521365,-0.02099239,0.04451573,0.02327412,0.058760256,-0.038808715,0.032682195,0.07532285,-0.046555266,0.008386705,-0.01442867,0.020974124,-0.025974026,-0.002215721,0.0154860625,-0.02709046,-0.03908256,-0.10757775,-0.06626925,-0.041689165,-0.034251064,0.012046642,0.010619826,0.028521482,0.10191547,0.008396251,0.022914156,0.040592283,-0.124795705,0.023573134,-0.014800103,-0.022389887,-0.020105733,-0.09758352,-0.05539189,-0.11039551,0.06011747,0.06203953,0.043464262,0.02634497,-0.012519852,-0.0013225791,-0.074538186,0.021824684,-0.06953351,-0.04161308,0.08586385,0.018763876,0.002165725,-0.058927912,-0.004719255,-0.01582712,0.04986461,0.0032883114,-2.5438705e-08,0.0869991,-0.044549156,0.14562836,-0.021113163,0.013341463,-0.033898942,0.0022412306,0.070965044,0.03514933,0.037908945,0.007173619,0.028547168,-0.028171157,0.0053587034,0.0573952,0.026190557,-0.07942798,0.0008551246,-0.05217842,-0.016984502,-0.06005684,-0.08610906,-0.071964934,0.06992114,0.058959737,-0.028147181,0.058334753,0.015174462,-0.03739727,-0.028872149,0.02205999,0.04149912,-0.03102904,-0.016761942,-0.086698405,0.039896,-0.01254438,-0.058673143,0.054298803,0.06931458,-0.014512323,0.034214064,-0.11506566,0.026416894,-0.025464997,0.025810502,-0.010421853,0.04121385,-0.09467527,-0.05510974,0.06543193,-0.026766721,-0.031388875,0.0051947944,-0.10645901,-0.0037596645,0.06892608,-0.019170912,-0.014868782,-0.035504416,0.0270855,-0.024717202,0.16356283,-0.06703608 +7.1.1.12,"The enzyme is very similar to EC 1.3.5.1, succinate dehydrogenase, but differs by containing two heme molecules (located in the membrane anchor component) in addition to FAD and three iron-sulfur clusters. Unlike EC 1.3.5.1, this enzyme catalyses an electrogenic reaction, enabled by electron-bifurcation via the heme molecules. In the direction of succinate oxidation by menaquinone, which is endergonic, the reaction is driven by the transmembrane electrochemical proton potential. In the direction of fumarate reduction, the electrogenic electron transfer reaction is compensated by transmembrane proton transfer pathway known as the E-pathway, which results in overall electroneutrality.",384,1.0,-0.058317978,0.014473461,-0.08784227,0.016075758,0.0971386,0.010680598,-0.053326212,0.042081818,0.0347348,-0.015170239,0.024436591,-0.03666556,-0.040096886,-0.06278022,-0.07892115,-0.022316672,-0.054765463,-0.032669444,-0.018730028,-0.084430605,0.050822824,-0.0497898,-0.034767814,-0.08055129,0.031694565,0.055906735,0.02016686,0.027390372,-0.12634179,-0.09950113,0.045776196,-0.07341211,-0.002345606,-0.03223903,-0.08599376,0.11775641,-0.07140453,-0.07084416,0.04229117,0.023820223,0.02539871,-0.00013667709,-0.08159225,-0.022054516,-0.04671095,-0.028955147,0.006295219,-0.0074520605,0.0035503889,-0.02636703,-0.029556707,-0.07382192,-0.0050368775,-0.02438348,-0.025041,0.023184542,0.006274119,0.012751254,-0.038184308,0.016880207,-0.0032485584,0.0038308885,0.0013092677,-0.009833381,0.026769973,-0.07293738,0.0873676,-0.08231763,0.013932582,-0.022192925,-0.04524581,-0.05001977,-0.02930252,-0.027310653,0.001169067,0.086505875,-0.012887832,-0.00021789847,0.039768513,-0.012441932,0.01701642,-0.010965808,0.0047351927,0.046229415,0.03363373,-0.0058047827,0.028215162,-0.08435348,0.00984662,0.08575822,0.053307403,-0.034039173,-0.018060971,0.009385231,-0.070449516,0.08252045,0.013597496,0.1289472,0.009773504,-0.06717388,-0.013441722,0.10386233,-0.045494784,-0.03980975,-0.010782562,-0.00833733,0.06632874,0.0866251,-0.027873915,-0.013981685,-0.025457986,-0.076021574,0.04360758,-0.0049362904,-0.022146253,0.1337152,0.056977957,-0.025689714,-0.024109289,-0.034904137,0.025949977,0.040816694,0.07843278,0.05014024,-0.0011364347,0.08419524,-0.11912304,1.47464e-33,0.035251245,-0.013948057,0.00022967823,-0.03128153,-0.019421168,0.0003953935,-0.094400816,0.0905116,-0.05085185,0.01699484,-0.067411564,0.0030142872,0.100636475,-0.045052372,-0.048191674,-0.055689264,-0.04533721,-0.059618905,0.014996066,-0.01979992,0.03388884,-0.042016838,-0.009174846,-0.032912888,-0.0028577587,0.021277761,0.00047992385,0.057670243,0.032742377,-0.02097962,-0.012211254,-0.05464904,-0.05724325,-0.021014562,0.014235773,0.02851496,-0.019539997,0.011590024,0.016735839,0.052218243,0.017756727,0.069645174,0.0055235084,-0.029320475,0.068532504,-0.01001319,-0.039341316,0.08708937,0.08565113,0.050880853,-0.011829187,-0.04367241,0.15452206,-0.02205368,0.027607173,0.030881226,-0.009358426,0.08424785,0.013512338,0.06052045,0.01766418,0.110442705,-0.01568949,-0.008334362,0.03794167,0.06047328,-0.07625131,-0.027308218,0.03834881,0.052375793,-0.08140992,0.0062344824,0.05985246,0.020578092,0.0053376933,0.023784928,-0.116681,0.027939001,0.02087954,-0.005115592,-0.026897943,-0.018323693,-0.009733344,-0.037416223,0.0016200932,-0.008287646,-0.03804104,-0.069650084,-0.010080933,0.008448538,0.064559646,-0.03991569,0.008507061,-0.00432371,0.04581766,-3.0503232e-33,0.037485898,-0.052574933,0.0050051156,-0.04233312,-0.039602656,0.1372251,0.026190972,0.014148003,-0.01824923,0.026323153,0.0552461,0.031844486,0.04468159,-0.0850293,0.033205,-0.037159268,-0.07077468,-0.0030243646,0.010722496,0.0030690231,0.017960133,0.12351904,0.01985878,0.038808674,0.0667723,-0.030752763,0.04623988,-0.0018826551,0.01932924,0.025929397,-0.010166305,0.0030314159,-0.031703584,0.012724369,-0.03502468,0.0085663935,-0.06551012,0.03932235,0.09226327,0.076149285,-0.054340906,0.014694516,0.06653463,0.073163904,0.0902475,0.10376954,-0.15884255,0.0466584,0.00335638,-0.038218964,-0.014091054,0.011400079,-0.09134848,0.012044938,0.045915578,-0.012043951,0.05060314,-0.020136321,-0.023392893,-0.024397835,-0.01527905,-0.044997048,0.07645329,-0.068820976,-0.011557976,0.002605506,-0.02467045,0.032918278,0.041670367,-0.045633353,0.05920414,-0.031597603,-0.013644753,-0.03291002,0.0023439056,-0.014970991,-0.00867546,0.019481545,-0.01150261,-0.019352011,0.032181416,0.033074044,-0.021709919,-0.10840064,0.02568748,-0.054934442,-0.0075823814,0.03251592,-0.028357346,0.033048514,-0.069023505,-0.011168428,-0.045556962,0.06015583,0.029979495,-4.134545e-08,0.039633937,-0.028028488,0.10489568,0.0351732,0.04368081,0.037447404,-0.067082174,-0.021608837,0.04407341,0.011115565,-0.05167254,0.10044383,0.013329499,0.043804467,0.04479281,0.024305923,0.008793453,0.06058136,-0.0014478322,0.010245883,-0.06862331,-0.04827141,-0.16639638,0.036153194,0.10055108,-0.09470506,0.038638223,-0.02052662,-0.032350767,-0.10520823,-0.035656635,0.027217748,0.10200492,0.04201017,-0.015765905,0.02350009,-0.052497867,0.0124889035,-0.05720315,0.031856675,0.014207818,-0.07619787,-0.056979857,0.0009867793,-0.03344689,0.05772295,0.08881944,0.027517824,-0.05865359,0.0562045,0.032418057,-0.067404516,0.038453035,-0.038837187,-0.07318598,0.04930238,-0.06174184,-0.06496774,0.03632543,-0.020412803,0.061202466,-0.0044500073,0.10987551,0.0074174865 +1.1.3.50,"A flavoprotein (FAD). This bacterial enzyme participates in degradation of certain C-glucosides by catalysing the oxidation of the hydroxyl group at position 3 of the glycose moiety. The enzyme was found active with assorted C-glycosides, such as carminate, mangiferin, and C6-glycosylated flavonoids, but not with D-glucose or C8-glycosylated flavonoids.",384,1.0,-0.103501886,-0.07434298,-0.111467294,0.038567316,0.07206574,0.026485434,-0.041978214,0.06513826,0.033196688,-0.057825845,-0.011771578,0.070114456,-0.07097267,0.0064934343,-0.10323497,-0.018161764,-0.055562645,-0.010899989,-0.06190502,-0.013559405,0.005675923,-0.0043310546,-0.009318568,-0.04798828,0.0314852,-0.038137563,0.006499124,-0.08047465,-0.039647,0.0119776605,0.08653281,0.056473732,0.10284955,-0.000105918436,-0.0063958284,0.0745622,0.06308769,-0.04328596,0.06053713,-0.016325282,-0.023104712,-0.0004648234,0.06591821,-0.01805618,0.08437232,0.0071742823,-0.022459919,0.08204388,0.004381828,0.03469624,-0.023087,-0.039489523,-0.097724825,0.041410662,0.024881704,0.002151046,-0.04233975,-0.081606396,-0.007901917,0.023927659,0.023538869,-0.01761114,0.066019304,0.052608166,-0.014725379,-0.12792532,0.001320861,-0.035179522,0.03313356,-0.0074756714,-0.016870119,-0.035731234,-0.06632056,0.021462863,0.032891672,0.049171273,-0.08472004,-0.04626402,0.04924556,-0.05750017,0.10652683,-0.03473754,0.11998022,0.1095536,0.033072144,-0.072188124,0.00050303177,-0.020753535,-0.0074064583,0.074136786,0.001407798,0.00920054,0.008344631,-0.009649428,-0.06843218,0.024803534,0.05325355,-0.06258936,-0.06446012,-0.031952318,-0.058698174,-0.02138878,0.059724048,-0.018987708,-0.05097318,-0.00324653,-0.051080022,0.10338527,0.023779193,-0.037167784,-0.017353581,0.026778119,-0.012882881,-0.12350159,-0.022144007,0.019569254,0.025532778,-0.06154228,-0.065730006,-0.01584261,-0.041264858,0.06353475,0.048824336,0.03463678,0.0070989714,0.027974132,-0.02212256,3.8835582e-33,0.055136055,-0.01255807,-0.03416024,-0.053651504,0.02756814,-0.041062947,-0.03872925,-0.023781378,0.04470412,-0.011592981,-0.029823251,-0.017728023,-0.014803833,0.02156114,0.071145326,0.0441172,-0.019958904,-0.06828342,0.09368426,-0.095220655,0.060795553,0.063514724,0.009594579,-0.010650801,0.062038846,0.020861015,-0.021223826,0.07179045,-0.0070946394,0.01353467,-0.0038299647,-0.048294984,-0.06877995,-0.010015043,0.013707077,0.06158948,-0.10675064,-0.0876172,-0.048727285,0.08897051,0.028042523,-0.015871331,-0.029388303,-0.018834202,0.025862824,-0.005139306,-0.060248807,0.1074081,0.013290202,0.121795066,0.03075978,-0.048837285,0.07920197,0.064427145,-0.06500401,0.06315028,-0.0069471314,-0.02642096,0.024594361,-0.0015595773,0.018262284,0.054820403,-0.013800106,0.054365512,-0.06278767,-0.012395329,-0.02910789,-0.058046564,-0.024823138,0.118122466,6.564095e-05,-0.028766865,0.0810875,0.015910016,0.04711396,-0.048915718,-0.029427404,-0.04240991,0.009645514,-0.018463656,-0.0254619,-0.032199133,0.01021203,-0.028444616,-0.01360274,0.057431106,-0.067090034,-0.08205908,0.0053030057,0.0006020437,0.007203263,-0.06872646,0.0058949594,0.056588236,0.0058515836,-5.3045083e-33,0.036683712,-0.12000945,0.049480956,0.009690393,-0.012640504,0.014101874,-0.0043255524,-0.028082319,-0.011379722,-0.0459188,-0.026419956,-0.024764514,-0.019526,0.034610122,0.027169231,0.020550607,-0.050105333,0.03423844,-0.013873984,0.020729933,-0.028367588,-0.008177662,0.020845816,0.0343696,0.033371683,0.00275783,0.006465971,-0.02879036,0.01457537,0.04619589,-0.005907615,0.014558941,-0.061594184,-0.037824698,-0.046556327,0.04952763,-0.021402802,0.029242374,0.0065358025,0.02203517,0.04358767,0.045444682,0.005464239,0.037002943,0.09585763,0.08454225,-0.061429027,0.045551945,0.043260418,-0.06738861,0.006139637,0.021139449,0.014983109,0.05753629,0.0535743,0.05928359,0.09027168,0.034497723,-0.032788105,-0.0015993175,-0.039180018,-0.12475794,0.04588351,0.0112823695,0.11426874,0.08086561,0.0324095,0.09722686,-0.0072099003,0.015308937,0.102119535,-0.033182643,-0.01613745,0.06362561,0.03328466,-0.0065716845,-0.061548803,0.03069441,0.020628218,0.025873136,0.053645387,-0.015346578,0.017249417,0.020504491,-0.08670707,-0.14864096,0.008190095,0.07311166,0.03473399,0.06020696,-0.03757879,0.046454642,-0.0065438286,-0.095369585,0.07725983,-4.001743e-08,0.03346215,-0.04319332,0.017527688,-0.044431463,0.07933753,0.019862145,-0.05559206,-0.018458178,0.020627074,-0.04644486,-0.087139964,0.13889061,-0.04731244,-0.06452004,-0.01082876,-0.014063815,-0.056540105,-0.009968504,-0.016346142,0.018233204,-0.12553832,0.035486676,-0.09373871,0.033865616,-0.028594056,-0.052491467,0.039604135,-0.0063257297,0.017845795,0.013134722,-0.011954386,0.08645552,0.006429119,-0.018582035,-0.12106314,-0.019324504,0.017502831,-0.051416107,-0.030609552,0.019583648,-0.07419036,0.015906723,-0.03986854,-0.039687086,0.014828104,0.009834285,0.024809975,0.007933288,-0.09749612,0.0028976935,0.0077353823,-0.02083577,-0.040165804,0.0019021451,-0.07348662,-0.038303368,-0.03288423,-0.054615024,-0.014042681,-0.09315466,-0.026901659,0.027387824,0.14343998,0.008332991 +2.3.1.309,"The enzyme acetylates L-lysine at position 252 of beta-tubulin, which is located at the interface of alpha/beta-tubulin heterodimers and interacts with the phosphate group of the alpha-tubulin-bound GTP. The acetylation is thought to attenuate tubulin incorporation into microtubules. The enzyme catalysing this activity (NAA50) also catalyses the acetylation of certain N-terminal methionyl residues. That activity is classified as EC 2.3.1.258, N-terminal methionine Nalpha-acetyltransferase NatE. cf. EC 2.3.1.108, alpha-tubulin N-acetyltransferase.",384,1.0,-0.038202547,-0.09308166,-0.05408136,-0.044452146,0.05622252,0.059666943,-0.01365725,0.011374316,-0.04648995,0.022509748,-0.006287598,0.035351787,0.03747749,0.022921586,-0.07586724,-0.013265711,-0.058546234,0.020583494,-0.0018148047,-0.031792443,0.023567239,0.04696054,-0.026892675,-0.026421625,0.070156485,-0.04694018,-0.024412083,-0.04077667,-0.00040605018,-0.0714064,-0.054075178,-0.020719964,-0.050615527,-0.08163185,0.092974044,0.0059706564,-0.0814131,-0.06925071,0.051572848,-0.0080811735,0.092457004,-0.03321805,0.010638263,-0.017192204,0.055565387,-0.01784498,-0.020743098,-0.0066297743,0.07930131,-0.020674301,-0.07693262,-0.036500752,0.0047591934,0.021641325,-0.0795627,0.010654889,-0.031757217,0.020364704,0.061448447,0.11949747,0.019188542,0.0039473944,0.044130113,-0.0643792,0.07740458,-0.0677635,-0.01723781,-0.07264008,0.063419655,-0.012510892,-0.06623697,-0.06759366,-0.047821894,0.018632783,-0.0073000384,-0.07948978,-0.05257138,0.06513901,-0.008913731,0.064169884,0.041477047,0.0065409015,0.015854176,0.009277407,0.029072525,0.03918495,-0.016355164,0.04421814,0.109903395,-0.005602365,-0.07232125,-0.017684072,0.010882214,-0.012816164,-0.05449983,-0.05715912,0.032913722,0.08502877,-0.04217109,0.029161425,0.050046377,0.031531412,-0.027739467,0.0029818476,-0.0764361,-0.021226928,0.050006554,0.040541187,-0.0016188067,0.0005960211,0.036843434,-0.07006158,0.06399334,0.018448919,-0.06261837,0.045534454,0.0022967784,-0.07078053,0.023520088,-0.04573799,0.06330817,-0.05083187,0.087663546,0.018993301,-0.04723902,0.111935884,-0.09681212,3.108654e-33,0.052353647,0.010165591,0.02801378,0.041764047,0.040184923,0.0116064465,-0.102690496,-0.05042352,0.03887173,-0.04171022,-0.067486875,0.010262072,0.025272269,-0.0036522413,-0.07801161,0.015089073,-0.0049768877,-0.027197244,0.0428388,0.013701,0.009101996,0.0044943406,-0.027475217,0.048524853,0.008807532,-0.052017797,-0.098972306,0.021793764,0.034007184,0.03323442,0.0014798943,-0.058800116,-0.027044807,0.045021452,0.016831644,-0.03593148,-0.026517455,-0.055158522,0.06936468,0.008969506,0.00974897,0.07787419,0.0013779454,0.017368285,-0.007060495,0.048735984,-0.017281162,0.054012615,0.003791036,0.0046545537,0.04672258,-0.03589758,0.053067133,0.010438885,-0.036006518,0.03733242,-0.100438364,-0.05122619,0.030119946,0.12817898,-0.026859762,0.021906022,0.0311041,0.025605416,-0.004995519,0.033630136,-0.043461338,0.017736366,0.08913948,-0.00287715,-0.06822038,0.009774916,0.093013585,0.070057616,0.06622817,-0.087148644,0.0019227973,0.020909647,-0.03479335,-0.023194782,0.045866363,0.02029396,-0.025239108,0.022874646,-0.019627964,0.0029993854,0.045204744,-0.013563702,0.017447809,0.0013007894,0.034346584,-0.011262438,-0.020996252,0.105123304,-0.0019318833,-3.2210382e-33,0.07548042,-0.0724761,0.028843284,-0.06635055,-0.062820144,-0.00025949362,0.06868924,-0.12479009,0.07007473,0.029287865,0.05859157,0.022858825,0.017129347,-0.028477166,0.054052655,-0.05398072,0.028062178,0.013461663,0.012345645,-0.0029295362,0.0082030585,0.0014627721,-0.0034311544,0.01834094,0.020890815,-2.5107001e-05,-0.010618089,-0.004039682,0.07170594,0.04658011,-0.07146977,0.04517874,-0.02175145,-0.055679623,-0.06755017,-0.0058378233,-0.012143297,0.012481632,-0.011804614,-0.02055596,0.07672446,0.026654895,-0.07291441,0.009891583,0.033024635,0.048830513,-0.006818293,0.009894154,-0.103105485,-0.07030376,0.048178457,-0.06750282,-0.017329123,-0.018943558,-0.028744597,0.08193561,0.03957051,0.09808714,0.020272978,0.00080335815,0.031846825,-0.03187374,-0.07012321,0.0044626263,0.044249486,0.027407184,0.02511794,0.042699046,0.029537354,0.04047868,-0.018672364,-0.014684786,0.11650565,0.079970285,0.045085985,0.0014552078,-0.07836989,-0.04571763,0.038210995,-0.103272155,-0.07319372,0.07095066,-0.021730708,-0.057883997,0.00058808277,0.005464004,0.0076175854,0.12975684,0.042874385,0.05597964,0.008385212,-0.06758513,-0.122055225,0.03659753,0.079136826,-3.9063277e-08,0.11672396,0.00975157,-0.011334913,-0.00014888617,-0.040027317,0.025568612,0.03606093,0.048432536,0.091223545,-0.027993908,0.002453877,0.10309912,0.04217344,-0.027543379,-0.020999767,0.1028885,0.044907164,0.04620031,-0.06469684,0.04774494,-0.038011435,0.004685438,-0.015763314,-0.0014979732,-0.06914535,-0.13968574,-0.034334224,0.115472086,-0.103121296,-0.122970164,-0.060646567,-0.03834286,0.0020540834,-0.102639265,-0.08607963,0.023636138,-0.016453352,-0.077383734,0.06658798,-0.02245102,-0.044510186,-0.10080142,0.027434252,-0.020745922,-0.039129388,0.03864038,0.028309334,-0.009637852,0.003752862,0.016614502,0.0041699475,-0.007939692,0.03788117,-0.08937654,-0.06580696,-0.034413822,-0.023783304,-0.0029528872,-0.026846197,-0.06206257,-0.020507937,0.018646572,0.116006635,-0.09470967 +2.3.1.310,"The enzyme, characterized from the bacteria Thauera aromatica and Geobacter metallireducens, participates in an anaerobic toluene degradation pathway.",384,1.0,-0.091737196,-0.034516968,-0.076089635,0.026765723,0.056316994,0.045035556,-0.02991677,0.0050164335,0.053925075,-0.010885306,-0.07048066,-0.05750165,-0.009964536,0.016020318,-0.07812896,0.038428217,-0.048713725,-0.0010741442,-0.055283885,-0.013983918,0.055154733,0.016088847,-0.020895073,0.009563006,-0.01384784,-0.009080128,0.025960863,-0.08871221,-0.09020688,0.0251724,0.024851892,0.029672695,0.04781446,-0.03968268,0.06750033,0.16366272,0.0030784921,-0.037098356,0.056629043,-0.008527484,0.057737146,0.044872634,-0.0053051817,-0.06627739,0.010531737,-0.034891192,0.01881545,-0.015894076,0.021490095,-0.014957986,-0.012051693,-0.020393562,-0.016743777,-0.025131892,0.02438119,-0.01373558,0.007077512,-0.051884294,-0.06966296,0.018945195,0.074123584,-0.039898504,0.029881,0.013342687,-0.01590167,-0.09380832,0.096439235,-0.034644313,0.037271306,-0.0406767,-0.13786389,-0.05574678,-0.07976764,0.021621458,0.014989277,0.023452858,0.06579025,-0.035965733,0.038534842,-0.10105254,0.041710157,0.014993048,0.039761353,0.01717178,0.045949984,-0.013911499,0.005355916,-0.00601454,0.08029164,0.06343913,0.014776079,0.082336366,0.043705635,-0.068869166,-0.09885709,-0.00018105714,0.066242404,0.03506418,0.028393205,0.002421512,0.034677193,0.01918388,-0.018727133,-0.07744467,-0.018352553,-0.027699616,0.019213023,0.08475676,0.08148445,-0.017528938,-0.010931356,0.04647407,0.07843775,0.020181844,-0.012821836,0.030224072,-0.010995202,-0.034867994,-0.0826231,0.086838216,-0.05255062,-0.06687763,-0.00087108056,0.047657188,-0.025027279,-0.03564883,-0.059281673,2.2992658e-33,0.07769118,0.00415954,0.028205743,-0.010818444,-0.01820087,-0.036230166,-0.053604327,0.02527478,0.00048341593,-0.04457481,-0.018143522,-0.09961515,0.0016589172,-0.02549037,-0.036604136,-0.010254483,-0.0529431,0.011493832,0.03617462,0.021899125,-0.059459403,0.06217867,-0.042266477,0.010625472,0.091827564,0.043749966,0.004165785,-0.031285577,-0.06333459,-0.021945627,0.04003806,-0.10939586,-0.10092032,-0.009444358,0.07817827,-0.026957853,0.013987637,0.050201133,-0.04100337,0.011208209,-0.02564721,0.043719184,-0.04371896,0.014386072,0.040827245,0.01231299,-0.022368642,0.09087032,0.057884596,0.058259178,0.04048836,-0.035567146,0.12682827,-0.06580896,-0.07029328,0.091251045,0.026278488,0.035761982,0.0797028,0.016693989,0.034539904,0.035842206,-0.08781191,0.05869899,0.048213556,-0.030693196,-0.013451209,0.028317755,0.028050194,0.091494754,-0.09716805,0.01028222,0.04926555,0.08567449,0.031574994,-0.041379113,-0.09682399,-0.04401762,0.054453865,-0.015899185,0.018526765,-0.04593403,0.011358029,-0.06075078,-0.09557218,-0.017551078,-0.012154349,-0.013284097,0.03174208,-0.04087879,0.09094949,-0.07856843,-0.059850436,-0.023467211,0.013339854,-2.949121e-33,0.08435694,-0.044406258,-0.05082908,-0.024508215,-0.026381232,-0.000684643,-0.0156078795,0.028703714,-0.021422243,0.012173192,0.13773634,-0.022146583,0.017400201,-0.027970575,0.03489734,0.00669321,0.053335313,0.034272436,-0.053583197,-0.06447059,-0.060247194,-0.02553136,0.0009782354,-0.076783024,-0.060578685,0.044803824,-0.071158305,0.075050846,0.07530601,0.050035052,0.039889116,0.03486886,-0.0010160856,-0.060401894,-0.053472113,0.00824692,-0.055393837,0.0049199983,-0.005043537,0.024497677,0.080338396,-0.016340578,0.00904454,0.086572334,0.0015504832,0.05604552,-0.12575778,0.004649166,-0.0048829145,-0.033284035,0.029694976,-0.0021574993,0.0044145305,-0.015514268,0.028368888,0.033266857,0.02843859,-0.046543553,-0.081804566,-0.0055972016,-0.06539224,0.0047853165,0.09320989,0.0524811,-0.040302776,0.10595152,-0.017220207,0.10998731,0.03200436,-0.025190257,0.09684145,0.071428545,0.015718315,-0.009858397,-0.04931738,-0.046428386,-0.024047337,-0.016995495,-0.0031999159,-0.03168294,0.035001896,-0.012102564,-0.0056061964,-0.07726488,0.010428906,-0.07500016,0.011046625,0.07311195,-0.012589865,0.014678856,0.019547943,-0.072113596,-0.06377062,0.048536353,-0.034309994,-2.9478208e-08,-0.06649663,-0.03825347,0.07517552,-0.02745875,-0.0064521795,0.052336127,0.05264844,0.037078425,0.051820934,-0.043304168,0.02459815,0.018568475,-0.010319672,-0.026024584,0.07605263,0.027988508,-0.06294868,-0.024722805,-0.024946734,0.012963948,-0.05753935,0.00033558963,-0.11760122,0.024663217,0.039650425,-0.016696755,0.028915124,0.08444679,0.0007403773,-0.031267703,-0.04246443,0.03514612,-0.03727697,0.0283215,-0.09217812,-0.015558878,-0.035554536,-0.06095404,-0.00093743333,0.04041717,-0.03525348,0.079811774,-0.12041595,0.014632408,0.08751179,0.024115581,-0.025096796,0.073832124,0.03117127,-0.03697416,-0.018042242,-0.03903956,-0.058297772,-0.0027333868,-0.08649698,0.043115612,0.044981357,-0.00017101686,-0.01914263,-0.03881904,0.01196234,-0.056967665,0.17955063,-0.03318445 +2.7.7.108,"The enzyme, commonly referred to as AMPylase, transfers an adenylyl (adenosine 5'-phosphate) group from ATP to L-serine, L-threonine, and L-tyrosine residues in its target protein substrates. AMPylation is found in both prokaryotes and eukaryotes. In bacteria AMPylases are abundant enzymes that either regulate the function of endogenous bacterial proteins or are translocated into host cells to hijack host cell signalling processes. Metazoans AMPylases are either enzymes containing a conserved Fic domain that primarily modify the ER-resident chaperone BiP, or mitochondrial selenocysteine-containing proteins (SelO) involved in redox signalling.",384,1.0,-0.047531396,-0.068706855,-0.06308621,-0.0029967572,0.006382136,-0.005011591,0.040006474,0.016886765,0.041814793,0.03219109,0.04013756,-0.017557865,-0.016792908,0.06916335,0.014146276,0.08756381,-0.039854143,0.053962838,-0.019148119,-0.060811333,0.07654364,0.06744773,0.0069450666,-0.009649975,0.026385704,-0.053206816,0.026723161,0.046553724,-0.09914494,-0.08857117,-0.0285212,-0.06118531,0.020008639,-0.03375899,0.048082404,0.13759747,-0.03234755,-0.06961938,0.027580837,0.038359445,-0.015573042,-0.010487562,0.009986058,-0.091021545,-0.099505045,-0.02889735,0.04805946,0.00092604745,0.06449738,-0.016678698,-0.0039219107,-0.030316567,-0.038627226,0.067806005,-0.017320076,0.02241794,-0.02993099,-0.04623487,-0.030182995,-0.027361268,-0.007583365,-0.007316856,-0.004379343,-0.01651912,-0.026281642,-0.018200826,0.03306193,-0.027154692,-0.013963094,-0.0072546075,-0.068137,-0.06585457,0.01648126,0.03956832,0.03075071,0.003076104,0.028562391,-0.065413594,0.01885956,-0.00027392316,0.027487636,0.009955913,0.029844329,0.00335782,0.0021402244,-0.016065434,0.081204794,0.01007645,-0.043963764,-0.06206399,0.03188328,-0.014953254,0.05397531,-0.04588382,-0.044453602,-0.041464787,0.014690156,0.0073724464,0.04569196,-0.026705608,0.049946427,0.044802904,0.023375133,-0.016352158,0.037147913,-0.01391071,-0.010324436,0.14926483,-0.04361006,-0.045868445,0.077096775,0.0406824,0.1030094,0.033587296,0.021638878,0.105909415,0.027484927,0.0011356138,-0.049053606,0.03335797,-0.03869135,-0.039104275,0.028831974,0.011043185,-0.028303934,0.0555954,-0.1587184,2.3727906e-33,0.097923264,0.045601714,-0.0088649355,0.013710553,-0.0048658215,-0.017358031,-0.059815325,0.044992566,-0.015796047,-0.11047178,-0.059670433,0.003999325,0.12884128,0.0060776495,-0.028852478,-0.040151015,-0.098731644,0.002592013,0.0703117,-0.019695707,0.00011788902,-0.015155137,0.009096361,-0.087403804,-0.04767417,-0.012728174,-0.015342318,0.063065834,-0.046499316,-0.0034393365,-0.017799754,-0.05273251,-0.03681393,-0.003268319,0.08329624,0.008448697,0.040909648,-0.02271151,-0.010452609,-0.017283764,-0.04744283,0.049601022,-0.05433907,-0.011817918,0.02429105,-0.097366236,-0.05854531,0.090820745,0.018843785,0.11413265,0.025901087,-0.075490765,0.091958664,-0.035957016,-0.08400088,0.050337452,-0.04527166,-0.030015223,0.0053121387,0.08161809,0.047633052,0.03426696,-0.03686568,0.018060697,0.036576334,0.04139705,-0.0023799925,-0.08434392,0.019351335,0.09587565,-0.03068572,-0.0034166048,0.048090886,0.048024036,-0.04353644,-0.04688742,-0.06009776,-0.0029709106,0.0047516273,0.09345481,-0.013068433,-0.033892553,-0.06317183,-0.015848173,-0.0783903,-0.064588554,0.01860476,-0.008923828,-0.035612833,-0.019384498,0.05029142,-0.061219122,-0.05500341,0.034187485,0.023047673,-3.4857944e-33,0.1668348,-0.07314371,0.019314164,-0.04794442,-0.010190891,0.0065203398,0.11467484,0.007114753,-0.040462878,-0.016429666,0.034438483,0.06375285,0.044911392,-0.03364739,0.014718263,-0.08074384,-0.025252502,-0.052676957,-0.012947382,-0.0005953425,-0.036332276,0.065671444,0.069238715,0.06777958,0.00940879,-0.03008809,-0.058335073,-0.0016547366,-0.061137836,0.03841863,0.010647344,0.052422784,-0.089126915,-0.06366629,-0.043624405,0.058151472,-0.061303947,0.016162839,0.043784384,-0.017619234,0.0356542,0.08777853,0.0055321995,0.082025014,0.005858703,0.056210104,-0.048868783,0.06615581,-0.024030937,-0.11996782,-0.039155867,-0.027926274,0.0015407708,-0.06597485,-0.0055722715,0.07117587,0.00033802987,0.03157563,-0.032438524,0.03271271,-0.0858408,-0.03789509,0.023331791,-0.045234673,-0.0017866726,0.037115876,0.017381229,-0.07438019,0.11580242,-0.009681347,0.08314485,0.0041765724,-0.0018706615,-0.029481988,-0.11464227,-0.038881574,-0.11737367,0.00846379,-0.0066418583,0.009207781,0.036000736,0.0044126376,0.0033727807,-0.042473778,0.0039289366,-0.02395972,-0.014888834,0.105409764,-0.0051123174,-0.017911429,0.008175323,-0.06736383,-0.009458352,0.026227307,-0.006277277,-3.8386048e-08,0.0297367,0.007385407,0.047113724,-0.0143198455,-0.024550145,0.09011652,0.030411817,0.025026452,0.10223782,0.017512582,0.0025066792,0.08088544,-0.044599455,0.04539678,0.014180195,0.075384356,0.011212994,0.07460647,-0.009663713,-0.01763156,-0.059267517,-0.019446762,-0.08330939,0.1087997,0.061057452,-0.0030162532,0.052960645,0.055780277,0.04047099,-0.044363294,0.0503559,-0.028812159,0.012978066,-0.0023777501,-0.016247435,-0.0015459007,-0.004159123,0.006819008,-0.061778028,0.03292413,0.00609628,-0.028616825,-0.07697515,-0.0142922355,-0.03748722,0.05269625,-0.0140967285,0.056017905,-0.033306126,-0.04591847,0.091458455,-0.11309953,-0.038036004,-0.021724902,-0.10166611,0.00458981,-0.04234196,-0.050273977,0.02079481,0.07114946,0.039492805,0.09368383,0.12070492,-0.07601033 +3.6.1.75,"The bifunctional enzyme catalyses the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. phosphatidate phosphatase (EC 3.1.3.4)). It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signalling role in stress response [6]. The phosphatase activity of the bifunctional enzyme is Mg2+-independent and N-ethylmaleimide-insensitive and is distinct from the Mg2+-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4 (phosphatidate phosphatase) [5].The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase [4]. ",384,1.0,-0.05026962,0.0060768137,-0.021392837,0.026732393,0.081756376,-0.020979475,0.01931127,0.017866071,0.010938932,-0.004863235,-0.05537089,0.02530603,0.051798612,-4.5811735e-06,0.021615783,0.014624614,-0.006728374,0.04767506,-0.046452325,-0.0002120048,0.110419445,-0.02588223,-0.03895275,0.031088699,-0.027911143,-0.063173726,0.07176243,0.017789401,-0.06281458,-0.0031597218,-0.110077985,-0.0194661,0.050023798,-0.035459124,0.024780445,0.08641411,0.01704715,0.028774602,-0.045659877,-0.028989693,0.027817002,0.06668934,-0.02295236,-0.006606004,-0.017440978,0.022562707,0.04096615,0.016629169,-0.007314098,-0.043670926,-0.053065818,-0.01825939,0.030017981,-0.0331311,-0.020801539,0.060885478,-0.123326205,0.02364982,-0.029570572,-0.05380212,-0.09360383,-0.091744766,0.013568323,-0.0015594517,0.07053817,-0.029761987,0.044043865,-0.027809978,-0.03273761,-0.028367262,-0.056828298,-0.01594561,0.005021657,-0.012149339,-0.028814994,0.10003593,0.09826351,-0.052678324,0.018706359,-0.047600992,0.07236188,-0.03200534,0.023924677,0.023736851,0.020663666,-0.0021095076,-0.016746964,0.056793462,-0.0045024115,0.08597725,0.07113565,-0.02788157,0.027496047,0.06431579,-0.01221859,0.05142733,-0.06443335,0.06436203,0.047686562,-0.023868348,0.04425418,0.08206914,0.0037037684,-0.00812395,0.05629563,0.06302901,0.033338197,0.015064704,-0.016624946,0.1104278,0.03380582,-0.03729001,0.058892414,0.0018802836,-0.033637285,0.034844104,-0.051188692,-0.012115616,-0.05564958,-0.05193701,0.032201186,-0.036398754,-0.03372699,-0.035846867,-0.025437534,0.09696833,-0.01562825,7.84425e-33,0.006392466,0.024323875,-0.00051507883,-0.03278453,0.021881564,0.010288857,-0.010787269,0.07446074,-0.03185476,-0.07062196,-0.029290982,-0.068840176,0.011232739,-0.04878435,-0.117494985,-0.032699067,0.041880533,0.061719388,0.103045315,0.032588247,0.00534753,-0.08084825,-0.046213746,-0.034658,-0.008572375,0.061063692,-0.053803228,-0.018205922,-0.027021958,-0.0351601,0.027159907,-0.123708904,-0.023401773,-0.058165636,0.13554844,-0.05973585,-0.012944323,0.0142613435,-0.027171824,-0.051441386,-0.08969932,-0.055656426,-0.06799207,0.060996216,-0.026973277,-0.082084194,-0.113182664,0.053835016,0.039005473,0.023131885,0.04016872,0.0075475513,0.08071971,-0.04328955,-0.054465994,-0.008988471,-0.0383997,-0.06448651,0.025960788,0.029288381,0.0011348926,0.05816901,-0.045214087,0.05802983,0.06833651,0.019380314,-0.15233573,-0.060069147,-0.040509477,0.104961686,0.022041535,-0.06707504,0.04522894,0.03351843,-0.03729139,-0.026825845,-0.001570694,0.01183507,-0.03317427,0.01941572,0.049032502,-0.06321744,-0.027594743,0.04681972,-0.07292334,0.0075510447,-0.0026752248,-0.05185428,0.012254516,-0.029478699,0.006455962,-0.023332532,0.005483523,0.06166292,0.005264072,-8.03655e-33,0.099775895,0.010967998,0.053709302,-0.10135104,0.01452544,0.031149587,0.046560176,-0.031318296,0.06005587,-0.069296844,0.029294878,-0.044330176,0.015537559,0.030443328,-0.03977678,0.02082819,-0.07213169,0.10467367,-0.007860028,-0.033932623,-0.013254154,0.09874837,-0.014196049,0.13565472,0.07163727,-0.011226074,-0.031191295,0.05476073,0.0038263623,0.14275311,-0.00036252916,0.109475985,-0.0389183,-0.04063079,-0.006351244,0.06647411,-0.02742484,-0.030489262,-0.006178267,0.054187637,-0.0233408,0.06408311,0.03422323,-0.026295584,0.06901212,0.09280733,-0.026644457,0.048026968,-0.044286504,0.021161022,-0.024514476,0.055264175,-0.038689747,0.09166146,0.11779316,0.06462335,-0.019320728,0.053668533,0.033133026,-0.095219664,-0.07155037,-0.10235904,-0.027923768,-0.0094808005,0.022163942,-0.00068430236,0.019557472,-0.022660945,0.04021992,0.051586207,-0.027793208,0.10342113,-0.008060337,-0.00826872,-0.08280613,0.060317066,-0.038081698,-0.028087512,-0.018573392,0.009288965,0.019051798,0.04134193,0.005972524,-0.0018101911,-0.08178167,-0.012611353,-0.028682254,0.054902725,-0.06433137,-0.036700297,-0.075858705,-0.12697288,-0.08003778,0.033409473,-0.07829431,-5.015299e-08,0.037030216,-0.02592664,-0.016970567,-0.0757292,-0.016864482,-0.037348643,0.062039934,-0.046746045,0.053464588,-0.041600592,0.04616239,0.01794061,0.050807323,-0.024394069,0.06937114,0.016674835,-0.01080308,0.027533907,0.004384371,0.013752049,0.06876865,-0.037802234,-0.08942983,0.08718772,0.07561133,-0.052144572,0.02926348,0.042349957,0.02006408,0.006407718,0.019819489,-0.0132228965,0.053097934,-0.027660085,0.008398162,-0.0031830154,-0.05974154,0.007259491,-0.074503094,0.065248825,-0.07305435,-0.01424736,-0.0022189533,0.00755022,-0.027945641,-0.054614607,0.016833564,0.065563604,-0.028505398,-0.030473541,-0.029935177,-0.013920515,-0.033445485,-0.023811413,-0.04065807,-0.017041933,-0.03989045,-0.024297426,-0.048194714,-0.03021532,0.01171059,0.060659077,0.08741594,-0.10938995 +4.3.2.11,"The enzyme, found in some actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. It catalyses the formation of (3R)-3-[(carboxylmethyl)amino]fatty acid by the addition of glycine and the release of the product from the acyl-carrier protein.",384,1.0,-0.0693788,-0.09304437,-0.110613056,0.0011378615,-0.027479574,0.09382976,-0.017973967,-0.0011590549,0.037625402,-0.024145102,0.0526367,-0.08069645,-0.09206099,-0.0120779,0.03220477,-0.005253277,-0.053082783,-0.020941436,0.022621142,-0.0770012,0.07445287,0.031491887,-0.0324224,-0.02679415,0.0042519574,-0.04221697,0.0053386874,-0.08767351,0.0062610065,-0.046873394,0.050417367,-0.13017155,0.104847535,-0.09200884,0.052367087,0.058713533,-0.0424484,-0.042060774,0.10461768,0.016265871,0.032269042,-0.045367826,-0.05439555,0.0030928978,-0.0049194824,-0.03472684,0.015175645,0.04469884,0.034226563,0.0039755427,-0.04230344,-0.050146773,-0.050440885,0.009427069,-0.027849449,-0.017032955,-0.0020236026,-0.003185258,-0.04953699,-0.007029723,0.059421305,-0.0021404433,0.02808663,-0.025831183,-0.04346064,-0.11302191,0.04515832,-0.071977995,0.08534406,-0.02514452,-0.052794587,-0.0983872,-0.08484563,0.0022597343,-0.049262177,0.008586145,-0.06742544,-0.014324349,0.018795338,0.00922563,0.059035715,-0.018901717,-0.004336884,0.14327644,0.032481384,-0.007959741,-0.015726672,0.0077260304,0.00061195856,0.057188794,0.00873076,-0.053509664,0.017483747,0.019041691,-0.05330738,0.01711948,-0.017012162,-0.03098228,0.026214143,0.0013114907,0.0074519143,0.034198705,-0.06642324,-0.07665338,-0.06021469,0.025082288,-0.06578025,0.003595212,-0.0054116542,0.05595682,-0.041513626,0.0006066306,0.004981257,-0.018057425,-0.043048017,0.070058376,0.05014823,-0.054900635,-0.012911608,-0.0008143152,-0.017840283,-0.022007966,0.051492658,0.057588533,0.0043127676,0.03365568,-0.107059315,-3.8722768e-34,0.038861677,-0.024127172,0.015032725,0.006869,0.024499165,-0.007110115,-0.0553251,0.022688098,0.03064621,-0.027735192,-0.052582137,-0.1369621,0.05601378,0.045386296,-0.008961623,-0.0078117955,-0.023803478,0.016852876,0.11150852,0.018866496,-0.03450675,0.055864632,-0.011613859,0.0012437154,0.0023578042,0.057726037,-0.044775337,-0.03516082,0.044083122,-0.0061135045,0.003459431,-0.08996019,-0.10668684,-0.007685458,0.13531828,-0.023222638,-0.0046915533,-0.0673267,-0.0010442205,0.08252528,0.021854997,-0.031946834,0.019393468,-0.014286624,0.058454737,0.10083336,-0.06899457,0.09897313,0.07408644,0.021884598,0.07423931,-0.028068352,0.14166695,0.028906317,-0.030490419,0.06614305,-0.06075505,-0.012480685,0.00399416,0.0067029553,-0.008777435,0.051515345,0.027800845,0.010273596,-0.024438523,0.009307159,-0.075673096,-0.021401046,0.00036227738,0.09273801,-0.008392198,0.014061161,0.07830688,-0.0009268895,0.03997134,-0.0038430146,-0.08701612,0.019880261,0.00600847,-0.028620288,-0.01915877,0.04235055,0.043582335,-0.06618208,-0.0563239,-0.0028173006,-0.044108093,-0.08159174,0.0448327,0.0228193,0.008527602,-0.053538527,-0.13693728,0.09933773,-0.053137124,-2.4254781e-33,0.076386124,-0.14698155,-0.0014496476,-0.11912202,-0.046939626,0.030668205,-0.05539343,-0.012732717,0.034510463,0.026903696,-0.015960991,0.0107209915,0.012342135,-0.020614924,0.035514135,0.021535503,0.0047726687,0.024080371,-0.009343798,-0.060759723,0.013133147,-0.016481983,-0.006376652,0.069201134,0.0027486589,0.0010657748,-0.030012002,0.07488566,0.08347959,0.057308387,0.03171213,-0.043263588,-0.047260106,-0.07903587,-0.015166568,0.08638149,-0.06430692,0.06841223,0.020573784,-0.023259288,0.025993615,0.009670855,0.052640337,0.038749058,0.078881994,0.0068912846,0.00378267,-0.005429518,-0.022276971,-0.10939542,0.06261866,-0.07406118,0.07463431,0.028885912,0.054249153,0.12097065,-0.007878746,0.004443253,0.026534818,-0.009325645,-0.01777762,-0.057465486,0.039608333,0.022172634,0.020970777,0.054518446,-0.0039193793,-0.015954884,0.03344357,0.0349141,0.043360602,0.03692769,-0.007638095,0.092480265,-0.022004839,0.012304056,-0.058046315,-0.08335248,-0.037755605,-0.011937236,-0.019611955,-0.042425774,-0.0057361363,-0.08954135,-0.057153042,-0.050252117,0.026778728,0.09289075,-0.0029499172,0.05458394,-0.015279819,0.05603592,-0.019275436,0.04121049,0.010051688,-3.9150123e-08,0.086805895,-0.025460318,0.054828726,-0.03228972,-0.070515394,0.035291594,-0.010048689,-0.02916397,0.016369727,-0.05013405,-0.02772794,0.014615416,0.022161733,0.030477198,0.055314235,0.06612779,-0.027262747,0.028713312,-0.022493947,-0.03662236,-0.094916694,0.041983843,-0.05009733,0.011106841,-0.013581891,-0.053029202,0.040266547,0.054010205,0.008737439,0.05931596,0.026868025,0.05099945,0.012808106,-0.014629678,-0.031018324,0.015680432,-0.032479856,-0.08393626,0.013453701,0.046114102,-0.006233283,0.026675925,-0.07903006,0.008911188,0.03433609,0.003089133,-0.075264424,0.024620552,-0.05169948,0.023060279,0.032507323,0.04565307,-0.07821932,0.046485394,-0.06597552,-0.021903047,-0.05920086,-0.058246024,0.0033582994,0.0058205235,-0.04448091,0.027899504,0.20273745,0.04718814 +6.2.1.76,"The enzyme, found in mitochondria, detoxifies malonate, which is a potent inhibitor of mitochondrial respiration, and provides malonyl-CoA to the mitochondrial fatty acid biosynthesis pathway.",384,1.0,-0.057365786,0.015001039,-0.00692519,0.08561209,0.034208637,0.01658234,-0.072484516,0.0023071365,0.061163124,-0.07257966,0.02878893,0.029350558,0.007703025,-0.068912335,-0.07212205,0.01656178,-0.044087578,0.061249938,0.013089,-0.037825245,0.058055107,0.10091574,0.014252839,-0.04563332,0.04267149,-0.022075979,0.04895117,-0.008799561,0.018674485,-0.058057398,0.015463104,0.009777795,0.013493575,-0.0072347033,-0.025294442,0.14897825,-0.001150574,-0.021877417,-0.021829264,-0.0854202,0.05316778,-0.0571136,-0.029192116,0.049852196,-0.059026368,-0.078371674,-0.07407671,-0.047340114,0.042893346,0.0015193771,-0.052596983,-0.032604173,-0.12128365,0.06819058,0.032267556,0.022525003,-0.03118845,-0.00082672277,-0.055872537,0.021838445,0.03244544,0.103449,-0.019869236,0.033617247,0.048402388,-0.037444755,0.041317515,-0.022893349,0.01808928,-0.07167446,0.00068978156,-0.10769719,-0.01587465,0.03787486,-0.057628416,0.0055444073,-0.03155839,-0.10644452,-0.004310315,0.046273775,0.021783303,0.012691386,0.067388475,0.09168537,0.004946514,-0.034885798,0.06722293,-0.060171496,0.02021829,0.012481057,0.038726337,0.01276501,-0.020787757,-0.024480905,-0.05135924,0.09438619,0.025374662,-0.0032510904,-0.03951339,-0.0019060703,-0.0087865535,0.082310334,-0.05983863,-0.11224407,-0.08105311,-0.01683854,-0.01861495,0.045559555,0.01633446,0.0008255918,0.06057425,0.0037743037,0.0076969424,0.02745638,-0.0012958691,0.15972142,0.021394284,-0.070676714,-0.052889504,0.050960217,-0.013007441,0.011288595,-0.008308771,-0.014542844,-0.007335788,0.011081823,-0.0655703,-8.743767e-34,0.037713334,-0.054533944,-0.016956149,0.05989829,-0.0008412438,-0.058350377,-0.055445593,0.015112463,-0.020219114,0.0022462315,-0.04641559,-0.045571886,0.014262541,-0.02880051,0.020638019,-0.052864954,-0.005875827,-0.02610691,0.110718586,-0.037703946,0.041358028,0.018514745,0.04069166,-0.081007876,-0.043401115,0.0856107,-0.010544513,0.025312068,0.08185509,0.017645212,-0.019787034,-0.060265373,-0.08760986,0.0031892553,-0.008648366,0.007984233,-0.08087194,0.009443231,-0.055985086,0.10008074,0.021133384,0.013381615,-0.04005269,-0.078511395,0.07325758,-0.07100121,-0.048868787,0.043031547,0.07312235,0.055035364,0.05242614,-0.053406816,0.06819305,0.04484156,-0.07851737,0.05072298,0.013830602,-0.027491631,-0.037107684,0.004997372,0.03884865,0.015695537,-0.0013785459,0.09567257,0.11374852,0.010736296,-0.061030276,-0.07803878,-0.08573477,0.104596734,-0.08210249,-0.025335664,0.08294936,-0.023093095,-0.025586829,-0.046174936,-0.059073646,0.06474861,0.007667165,0.014163653,0.045182526,-0.038542937,-0.019944,-0.0007791669,-0.0031185842,0.023511646,-0.04209368,-0.001572712,-0.025768759,-0.0032803381,0.09479885,-0.01058018,-0.047075097,-0.039987136,-0.038107216,-1.8085087e-33,0.095703624,-0.1260554,0.06864225,-0.112402506,0.0015903703,0.068793945,0.022500496,-0.012641664,-0.011624017,0.0298564,-0.0050998903,-0.004051667,0.041467257,-0.034940735,0.039660614,0.033069365,0.021636797,-0.006302958,-0.056014173,-0.028815912,-0.002399852,0.15340194,-0.011221333,0.07064795,0.008581821,-0.058956698,-0.01267759,0.0363939,0.018623115,0.03247394,0.021361532,-0.00066876266,0.015522257,0.00038527182,-0.008148594,0.05250931,-0.058265112,0.016223384,0.0054028006,0.010346663,0.008665298,0.04025931,-0.018746516,0.012686592,0.068551436,-0.0282907,-0.13926132,-0.05183018,0.026096232,-0.08230086,0.061405193,0.027939029,-0.05184514,-0.0054739704,0.05377546,0.060008246,-0.051314343,-0.012096138,0.05590611,-0.008432924,-0.09600194,-0.017028475,0.01079796,-0.017500874,0.043554913,0.09130006,-0.072246514,-0.0020950723,-0.045263156,0.027259847,0.052086644,-0.004957494,-0.04095623,-0.002101767,-0.057641648,-0.03325743,-0.0202518,0.013768866,-0.030973395,-0.039460395,0.029170819,0.019220926,-0.031068547,-0.072499216,-0.08372387,-0.10099589,-0.010723447,0.100661024,0.033151474,0.0018167633,-0.002264873,-0.07576353,-0.039399724,-0.012175118,0.072787724,-3.00424e-08,-0.026501305,-0.05220431,0.041283775,0.02490643,-0.029645408,0.04095237,0.06712837,0.046071663,0.0089410525,-0.0023158311,0.006352947,0.06090888,0.021841481,0.045141406,0.036561724,0.044585336,-0.009500538,0.10202129,-0.050584804,-0.040039815,-0.018481467,-0.012469857,-0.046642374,0.033826888,0.01077968,-0.052566994,0.024538131,0.008910169,-0.022018382,-0.070979685,-0.032773614,0.040010653,0.054551996,-0.0047218013,-0.069526054,0.03219275,0.023910452,-0.06824404,-0.015376635,0.10388329,0.016975988,0.013279963,-0.072738744,-0.009066756,-0.029317368,0.021031415,0.055695295,0.022238338,-0.014939781,0.06743467,0.008220103,0.046408564,-0.06506893,-0.052840747,-0.06509929,0.016625825,-0.019628692,-0.042786945,-0.040996764,-0.055730566,0.09252379,0.038443998,0.20045759,-0.03702875 +1.1.1.434,"The enzyme, originally described from the bacterium Xanthomonas campestris pv. campestris, participates in an L-fucose degradation pathway. It can also act on 2-dehydro-3-deoxy-L-galactonate and 2-dehydro-3-deoxy-D-pentonate.",384,1.0,-0.004555983,-0.042581197,-0.051400643,-0.0332247,0.12500697,-0.017655618,-0.047641054,0.03940284,0.03722205,0.0035892145,0.046221662,-0.047684304,-0.029923568,0.057752475,-0.048799627,0.042770978,-0.089172795,0.018913377,0.015033247,0.046859447,0.10280278,0.03363095,-0.028634483,0.00018163996,0.07438284,-0.026508564,-0.0042132963,-0.03780179,-0.047810603,-0.10344696,-0.008002314,-0.006548911,0.09837892,-0.00023091891,0.06772785,0.09130246,-0.027763756,-0.06292642,0.06529132,0.01706755,-0.032028623,-0.043763373,0.04959416,-0.06847087,-0.06821634,-0.01035826,-0.029228272,0.03351413,-0.02698852,0.024496462,0.0019124593,-0.04423057,-0.017202662,0.0026737403,0.023588626,0.004297487,0.0025752655,-0.025025425,-0.082889006,0.027633613,0.09706675,0.13177097,-0.02866565,0.019393303,-0.016525146,-0.09267049,0.046523903,-0.035025623,0.0046790116,-0.02346754,-0.03496915,-0.06732776,-0.014702663,-0.038777627,0.06931019,0.07168239,0.00076106645,-0.04345881,0.005212044,-0.04300399,0.053134173,0.07497879,0.07131643,0.028888453,-0.008561067,-0.072275445,0.0038502393,0.00618255,0.03879454,0.029480021,0.020609012,-0.009495452,-0.10203334,-0.012466095,-0.019830767,0.039316274,0.083898805,0.0065358793,0.03367195,-0.02173239,-0.04194281,0.04483275,-0.061186533,-0.0770728,-0.02190046,-0.00589489,0.036216803,0.08892359,0.012198857,-0.078398265,-0.007835187,-0.012365113,0.07385916,0.019878369,-0.048981223,0.09295396,0.06505569,-0.019715,-0.08243701,0.024352804,0.014721744,-0.054411147,-0.0013785356,0.07393849,-0.03123064,0.042741045,-0.072952434,7.741696e-34,0.040327728,0.041797448,-0.032402627,-0.0055922503,0.069989495,-0.04996949,-0.02668357,-0.025307965,-0.057619862,0.032790773,-0.08676612,-0.069087595,0.024127107,0.021609286,-0.05091696,-0.01198667,-0.036731273,-0.0052646883,-0.01685421,-0.0032693015,0.03293279,0.016038705,-0.0406817,-0.041909963,0.045313247,0.07295605,0.07420964,0.0293311,0.049418446,-0.016514534,-0.001024415,-0.12024917,-0.09770216,0.03377666,0.086302206,0.05028323,-0.059087988,-0.07183546,-0.021733498,0.01344909,0.034743834,0.052004047,-0.017273199,-0.013476919,0.019529805,-0.02342217,-0.02927384,0.07437732,0.05475183,0.04514228,0.09850114,-0.027513035,0.020207357,-0.021829613,-0.044723626,0.030233385,-0.05128645,0.015277307,-0.020794522,0.05150684,0.016902268,0.029387955,-0.05510512,0.01688475,0.035636645,0.01412322,-0.01546084,-0.05792944,0.010422272,0.042081412,-0.13712557,-0.09979759,0.11289669,-0.007484655,0.028605385,-0.027814634,-0.060751043,0.01433181,0.03664941,-0.035560623,0.0023682513,-0.061382376,0.014311475,-0.028905014,-0.098336875,-0.034928445,-0.013875011,-0.035951737,0.017418453,0.06834951,0.044251803,-0.047003098,-0.011614347,0.004021885,0.01376178,-1.8736695e-33,-0.028350284,-0.048544034,0.07324922,-0.05297292,-0.07093661,0.06357965,-0.037963968,-0.019459264,0.0040813824,-0.022442713,0.055978525,0.031618968,0.018567648,-0.07675022,0.025638718,0.05801652,0.06421732,-0.005847653,-0.061182,-0.0071844347,-0.015048791,0.11731909,-0.024638321,-0.026282057,0.045482803,0.011824968,0.033272475,0.07645915,0.08860296,-0.0019719151,0.020039298,0.05436764,0.013246823,-0.04122522,-0.031065106,0.027648708,-0.055746157,-0.022533296,-0.0004475403,0.0009226781,0.046914857,0.009281947,0.049430642,0.07715234,0.060949177,0.101985835,-0.0901825,-0.05647148,0.0839703,0.011479937,0.012824838,-0.062699094,-0.053316895,0.012611902,0.013502235,0.0327189,-0.03125929,0.0069341934,-0.046869986,-0.0029898162,-0.018956095,-0.056963872,0.06471174,0.011767436,0.041081384,-0.019027244,-0.041143257,0.05847947,0.003155776,0.0036956908,0.12303215,0.0503836,-0.037856422,0.045427777,-0.07497855,-0.027528161,-0.11328002,-0.03612587,-0.026608659,-0.04359012,0.03932223,-0.00408082,0.0055977637,-0.060827438,0.054778207,-0.085206784,0.027435781,0.17868608,-0.00855826,-0.0118727535,-0.01790194,-0.024745103,-0.05439731,-0.0022528134,0.08978989,-3.8810605e-08,0.019722,-0.06105168,0.005267466,-0.032536175,-0.04331552,0.017723417,0.06842137,0.03209587,0.057731055,-0.016109705,-0.055909265,0.111853935,0.009327018,-0.05302493,0.021014191,0.015072548,-0.005056952,0.038271222,-0.039770115,0.021379959,-0.07172527,0.006562157,-0.09974451,-0.009857373,0.010935097,-0.042926814,0.07136418,0.08587801,0.038228214,-0.065317854,0.0011510103,0.069175325,0.011679495,-0.024166068,-0.11299522,0.07095884,-0.0755117,-0.043896724,0.005407894,0.052552797,0.009228552,0.035485882,-0.07349022,-0.013422272,-0.056250814,0.039650906,0.0035674237,0.03673632,-0.028599417,0.013294893,0.04548412,-0.03130721,-0.06190636,-0.02371071,-0.077311166,0.03863545,-0.017923843,0.020048361,0.033274733,-0.07197485,-0.041475166,-0.015689341,0.19099222,-0.052541547 +1.1.1.435,"The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme catalyses the oxidation of beta-L-fucopyranose to L-fucono-1,5-lactone, which is unstable and is rapidly converted to L-fucono-1,4-lactone. The alpha anomer is not recognized. The enzyme can also act on beta-L-galactopyranose and D-arabinose with lower activity. NADP+ is a better cosubstrate than NAD+.",384,0.99999994,0.0064837597,-0.067707054,-0.087338746,0.007504461,0.09364379,0.068426736,-0.11395818,0.034762375,0.051415157,-0.012831942,-0.0017177922,-0.0034016652,-0.07856655,0.031953588,-0.10299742,0.13554627,-0.05958575,0.03806541,0.009037448,0.030046772,0.030593086,-0.0068480573,-0.020576647,0.036555983,0.085015915,-0.0439115,-0.036411043,-0.020291898,-0.077771045,-0.1030351,-0.044888683,-0.03058881,0.05870959,0.004041563,-0.007525618,0.07572968,-0.050954636,-0.08652377,0.12264671,0.03602162,-0.030763164,-0.02310855,-0.039321363,-0.037315276,-0.05085266,0.0056105834,-0.022790194,0.07262008,0.1113589,0.015667144,-0.058072563,-0.04589104,-0.044596363,-0.029205762,-0.03192671,0.0059303576,0.023963619,-0.051947434,-0.014466629,0.025073398,0.045178693,0.036702972,-0.009962323,0.070393324,-0.013263625,-0.05347886,0.04429449,-0.06601282,-0.03307987,-0.03075744,-0.06811217,-0.050843157,0.00617789,-0.05443297,0.072532445,0.075934865,-0.03062395,-0.044318862,0.024692332,-0.00060317834,0.081455976,0.018483058,-0.014783758,0.009958143,0.025668062,-0.05884853,0.0030105594,-0.0028351685,0.042418253,0.029358063,0.033250887,0.009977678,-0.0061323363,-0.0050821146,-0.069854304,0.035579555,0.05743761,0.029632848,0.01632558,-0.040335603,-0.08445584,0.02317441,0.025695538,-0.07185299,-0.037188623,0.0012015919,0.04262671,0.074738555,0.10039426,-0.086362034,-0.034561314,0.008598315,0.06169352,0.028624244,-0.026818408,0.0932937,0.05242713,-0.06238391,-0.05244805,0.00795135,0.03548479,-0.043813486,0.04621151,0.031680886,-0.04043315,0.023298535,-0.06983605,9.04869e-34,0.08667444,0.06902298,0.023268618,0.013058996,0.030679258,-0.027326109,-0.091572866,-0.0619981,-0.019548168,-0.015703887,-0.015884949,-0.042602222,-0.014308878,0.0361236,0.008491962,0.027160352,0.014655038,-0.028289832,0.023778275,0.021686302,-0.007320724,0.02234012,-0.05515464,-0.028207667,0.069120534,0.08511347,0.03205558,0.08919839,-0.002945069,0.012584671,0.026009694,-0.0779816,-0.13182972,-0.0014109683,0.03386123,0.024529891,-0.081658304,-0.045815382,-0.017528603,-0.037915584,-0.017905733,0.055401463,-0.06859076,-0.016685098,0.046644174,-0.057675235,-0.026565064,0.10628595,0.023809606,0.08202263,0.002778129,-0.060084056,0.056132816,0.027721616,0.0028119285,0.007164292,-0.03324879,-0.011210464,0.0036757921,0.080973074,0.018883413,0.050023273,-0.019785015,0.028587697,-0.0109864175,-0.03931097,-0.03231768,-0.040760122,0.04703045,0.033054378,-0.012531654,-0.008719037,0.054656737,0.02307073,-0.027568385,-0.04428508,0.016829181,-0.054530673,-0.009434719,0.0045601004,0.015822452,-0.060530752,-0.017101318,-0.024566434,-0.032208268,0.05035731,0.0006708209,-0.020460369,0.03426844,0.041884936,0.016870435,-0.053169016,0.018141743,-0.0033810812,0.03379885,-1.9722846e-33,0.07979298,-0.1075059,0.0712548,-0.078888886,-0.08611581,0.004711728,0.020531958,-0.011312551,-0.002906373,-0.044399004,0.010531557,-0.01978915,0.03752844,-0.0932357,0.046356432,0.027212854,0.048151214,0.021096488,-0.072591536,-0.012119841,0.0075891623,0.12166337,0.07081976,-0.011315929,0.054843884,-0.0015960517,-0.05466316,0.058473118,0.023890764,0.06628321,0.0202648,0.036675204,0.01917786,-0.051762972,-0.0057934206,0.013459917,-0.095818505,-0.011202746,0.08395993,0.032971855,0.0690528,0.0674798,-0.016870057,-0.033079952,0.05127544,0.08145993,-0.09134439,-0.023646588,0.12733136,-0.034986086,0.018895509,-0.027767187,-0.045876104,0.01742056,0.040357567,0.052724365,-0.011422943,0.022751689,-0.05458239,-0.049254794,-0.05951295,-0.046356205,0.0068306653,-0.040069126,0.072175466,0.0418266,-0.021343654,0.053978562,0.054417983,-0.0011775924,0.07694467,0.01527171,0.025515066,0.090915106,-0.06049044,0.012417256,-0.1667014,-0.033298694,-0.043174773,0.055658277,-0.02872748,0.020737642,-0.021422034,-0.032959625,-0.014055571,-0.09539711,-0.007996827,0.12707542,-0.012998886,-0.0062981113,-0.006396554,-0.02339572,-0.0026429037,0.032074295,0.043043997,-3.981121e-08,0.09056627,-0.033634897,0.07642789,-0.044738926,0.0022023334,0.0241883,-0.019686086,-0.043881137,0.03602002,0.0119568985,-0.05552542,0.15737051,-0.001031165,0.029925037,-0.00642541,0.0015314403,-0.017149117,0.027308123,-0.010260457,0.0073401476,-0.116014875,-0.007940972,-0.06562578,0.059681617,-0.009023572,-0.040083777,0.024444094,0.0268488,0.022389473,-0.05051476,0.02970874,0.05514672,0.0140170595,-0.048227515,-0.101835206,0.03833644,-0.06701116,0.0018436897,-0.034266792,0.115422346,0.021029657,-0.021159088,-0.057419654,-0.00493913,-0.06687962,-0.02762747,0.021259367,0.00022695588,-0.053552255,-0.0054135174,0.05408868,-0.04778895,-0.056599595,-0.010404627,-0.045843016,0.0016874291,0.01071885,0.03129443,0.02885389,-0.10115543,-0.018503807,-0.04625569,0.17570806,-0.07779668 +1.1.1.436,"The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+. ",384,1.0,-0.087830015,-0.02512615,-0.1070365,0.06526089,0.040876843,0.0088909315,-0.09948549,0.052045688,0.04743195,-0.0018755541,-0.03608993,-0.017290624,-0.08537837,0.017385917,-0.052154496,-0.013392334,-0.10074342,0.03432521,0.04314314,0.03368632,0.032439046,0.032346275,0.017000258,-0.03322983,0.023939908,0.026414316,0.020046152,-0.021993447,-0.042891916,-0.089622684,0.09622696,-0.010127417,-0.022914188,-0.0070261764,-0.05860552,0.07720969,-0.022162475,-0.06884561,0.055069096,-0.024261374,0.028406126,0.049978327,0.062342748,-0.039433613,-0.005358668,-0.01872388,0.059950784,0.04446701,0.023143832,0.011636463,-0.046999224,-0.039438717,-0.040567506,-0.029136168,0.025423706,-0.0016142378,0.04500969,-0.0819156,0.004761234,-0.028416775,0.059113976,0.036081187,0.004331922,0.06871302,-0.05628017,-0.06768466,0.08894393,-0.04298486,-0.034824356,-0.019655209,-0.078326106,-0.014911713,-0.030638624,-0.044480365,-0.008579837,0.030950686,-0.038991746,-0.031665668,0.07727539,0.0383199,0.016909406,-0.04783842,-0.05826918,0.0920477,0.015335319,-0.016656164,0.009803419,-0.0029206276,0.013106346,0.038546078,0.0070894356,0.04015888,0.016447164,-0.07594694,-0.1067762,0.01624345,0.087421134,0.056573782,-0.022994354,-0.01980086,-0.014751133,0.020893654,0.06155732,-0.10800479,-0.055567272,-0.034979176,0.035246085,0.124605976,0.055252675,-0.017381608,-0.013295376,-0.0048170327,0.01312791,-0.066129975,-0.04128651,0.122855455,0.0012794607,-0.113928586,-0.04869417,0.05005464,-0.01746886,-0.018944943,0.019950945,0.032163624,0.0057140584,0.023213927,-0.0605141,4.4125086e-33,0.088366464,-0.048998415,-0.02169682,-0.05057312,0.06808989,0.02039019,-0.08243368,-0.018509816,-0.011736855,-0.002499179,-0.058279954,-0.03854196,0.07044891,-0.052360274,0.02531488,0.03291983,-0.083398014,-0.1199353,0.033273313,0.01790965,0.08181292,-0.0077259387,0.0051055327,0.0684861,0.015660955,0.057608802,-0.007205269,0.0631118,-0.0037273245,0.0035378966,0.10638694,-0.08327585,-0.13487162,-0.00692504,0.08707586,0.0071344282,-0.06815554,-0.025418349,-0.0025075378,0.035417978,0.009064181,0.07267263,-0.024093483,-0.0019933942,0.051530432,-0.08427336,-0.029683627,0.1409002,0.065052405,0.08389055,0.050336972,-0.025461523,0.08676198,-0.005001611,-0.0015656267,0.07305697,0.002383674,0.054284256,0.01927692,0.035261177,0.015762487,0.012507834,-0.027345097,0.02239633,-0.0662926,0.077068694,0.040897857,-0.0014281925,0.025240874,0.0038624357,-0.04422007,-0.024484271,0.03845259,-0.02549976,-0.00010728825,0.026304312,-0.05612847,-0.033885866,0.065106444,-0.054400478,0.030105548,-0.04240194,-0.008684042,-0.013661612,-0.03137874,-0.027422845,-0.07087259,0.012000575,-0.025988946,0.023257276,0.10032709,-0.077082686,0.026652051,-0.040891256,0.020965088,-6.098308e-33,0.012881629,-0.06489465,0.03516897,-0.080683604,-0.027850606,0.08732315,0.030403577,-0.02587082,-0.0061233467,-0.04308733,0.059459582,0.028813744,0.045120392,-0.006028619,0.10755485,0.013023569,-0.022679884,0.01019193,0.055812165,-0.005192922,0.030248916,0.03940077,-0.010414989,-0.071006306,0.08245819,-0.010799095,-0.11641189,0.009956348,0.04021215,0.032965485,-0.027659478,-0.021063723,-0.011206432,-0.08461279,-0.07128147,0.016448818,-0.07374896,0.006622644,0.018488804,-0.0046098684,0.03269549,-0.021001637,0.0069688023,0.09872401,0.04669069,0.061592847,-0.17424956,-0.082176484,0.005929036,0.01146288,0.009855204,0.030349351,-0.044563882,-0.04955079,0.022304045,0.064388,0.03261391,0.05772096,0.0086541325,-0.049364775,-0.07094842,-0.06872532,0.057816308,-0.054135013,0.029044144,0.03383923,-0.019004522,0.02347732,0.018094039,-0.076108746,0.027793221,0.043529272,0.023869796,0.07894415,0.006562723,0.029325884,-0.0336052,-0.049005814,-0.042980976,0.0037633097,-0.0009424618,0.036526352,-0.0041107913,-0.07582077,-0.01016148,-0.062481403,-0.024462188,0.044243287,-0.0014676969,0.01930221,-0.009411997,0.0100450525,0.00665102,-0.004799639,0.011690613,-3.3846305e-08,-0.07098527,-0.03360858,0.07982741,-0.029622966,0.031770017,0.060023308,0.05036319,-0.0014757429,0.027516061,-0.088044636,0.048477996,0.17106436,0.0067994595,0.05326088,0.034232285,0.01947308,-0.037647285,-0.04767104,-0.050506353,0.003350923,-0.083913855,-0.022547284,-0.09834819,0.07019129,0.029873328,-0.043166865,-0.012357068,-0.010560576,-0.020890554,-0.07250814,-0.04970846,0.08039521,0.027957968,-0.0076826476,-0.14695182,0.012561716,-0.05163992,-0.0033716024,-0.049533185,0.05016653,-0.0027507115,-0.013630451,-0.07974074,0.002695195,0.0042398656,0.054355998,0.0002305147,0.030149816,-0.047887042,0.029647898,0.02542705,-0.048819307,-0.047470182,-0.033172525,-0.090193525,0.012093386,-0.00014887727,-0.034805764,0.000401399,-0.040794812,0.030413905,-0.03006473,0.12065607,0.012329973 +1.1.1.437,"The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin. It is a partial polyketide synthase (PKS) consisting of only a dehydratase (DH) and a ketoreductase (KR) domain.",384,1.0,-0.045565564,0.08885023,-0.14310253,-0.059040017,0.06624404,-0.024540542,-0.090896584,0.059813425,0.06327085,-0.050605524,-0.0020582487,-0.08189098,-0.08307645,-0.016139908,-0.09531206,0.02073498,-0.05812265,0.06062987,0.032202687,-0.030758537,0.081222646,0.034871385,-0.020362513,0.030558037,-0.011562487,0.02687878,0.08911678,-0.0052050306,-0.037015866,-0.04795329,-0.06438799,-0.027509198,0.052911498,-0.013349812,0.083367914,0.20967324,-0.08656977,-0.005823499,0.052232083,-0.047650814,0.08284867,-0.09493694,-0.025647016,-0.05351113,-0.06312705,0.067287184,-0.04221348,0.034698844,-0.014963155,-0.011211281,-0.04241171,-0.039932307,-0.01823399,0.015383448,0.06831859,0.02964003,-0.019971393,-0.012854464,0.004816755,-0.0103230355,-0.010781452,0.02208084,0.010848151,0.007899067,0.027484456,-0.06702651,0.020407123,-0.022659115,-0.047320608,-0.067849964,-0.04927528,0.002369347,0.031460114,-0.014080028,0.02846083,0.06007377,-0.043404028,-0.008541334,0.030715179,-0.03374889,0.097480245,0.024686567,0.043174725,0.036666576,0.025958551,-0.025473686,-0.024686871,0.0012601406,0.0139050195,0.013554144,0.025462117,-0.0439725,-0.021660103,-0.006898443,-0.016614877,0.062177308,0.020057822,0.064281315,0.02266448,-0.016149199,-0.04989574,0.011832858,0.032938216,-0.0906824,0.020214856,-0.047819432,-0.008424412,0.053297203,0.101495005,-0.020237552,-0.074597776,-0.002465775,0.049623143,-0.03178148,0.0759798,0.0123618385,0.00034157146,-0.010883598,-0.006627424,-0.008429219,0.01183688,0.020924872,0.015159009,0.06637575,0.005736624,0.0042740055,-0.10695533,8.989764e-34,0.06795118,0.04444556,0.029846588,-0.02293507,0.017599508,-0.059884112,0.020264542,-0.07833158,-0.06921981,-0.053659484,-0.07291671,-0.08758619,-0.05237021,0.07773956,-0.0121647995,-0.0228291,-0.0059548207,0.011321179,0.017743768,-0.006382415,0.042478815,0.018736543,-0.092459634,0.045238007,-0.0007119641,0.08440373,0.006857519,0.005298865,-0.005458033,-0.014822485,-0.026780881,-0.037653666,-0.06236431,0.031204395,0.031878527,-0.0063763475,-0.03399035,-0.043853045,-0.054163516,-0.008445378,-0.033882026,-0.06427116,-0.035692185,-0.053088788,0.02336304,0.027528852,-0.03568736,0.101592444,0.006406473,0.040751826,0.0510524,0.023951976,0.06566621,-0.008594966,-0.032111563,-0.005650937,-0.030756425,-0.05541182,-0.0039101196,0.024966717,-0.022996666,0.04789089,-0.05199735,0.047499366,-0.02481355,-0.013532092,-0.03755717,-0.06431374,0.032735456,0.038109,-0.058871016,0.01571616,-0.013738364,0.025258895,-0.008331332,-0.02147415,-0.06784334,-0.039349426,-0.02327684,0.03858576,0.02837835,0.023678832,-0.031700596,-0.09794154,-0.10122256,-0.03340659,-0.031248959,-0.063177176,-0.027739715,0.024786415,-0.0660589,-0.10415674,-0.037528135,0.056665692,0.04695375,-3.290877e-33,0.07153348,-0.09204685,0.036129847,-0.022709874,-0.06680899,0.07780981,0.065303385,-0.0015469257,0.013557934,-0.015550206,0.0063754953,-0.03235261,0.044931933,-0.017528895,0.00051895913,0.085724935,-0.0046160948,0.10059312,0.022471465,-0.060264856,0.010060178,0.13301645,-0.004802489,0.06866928,0.05341516,0.041096624,-0.04142798,0.098033994,-0.019788928,0.031161642,-0.019979551,0.030986296,0.0050262446,0.013773141,-0.09337076,0.011984264,-0.080671825,-0.015348692,0.060871657,0.05779135,0.02227556,0.008821716,0.03831328,0.09075621,0.0071712187,0.09216782,0.010263438,0.020485017,0.07303137,-0.08320652,0.0059138522,0.08758442,0.015416823,0.04120107,0.012118059,0.033135176,-0.0059533915,0.020623075,-0.016514752,-0.05201455,-0.06598302,-0.09039647,0.05279803,0.049631204,0.021775313,0.044026006,0.014796277,-0.021662792,0.10967759,0.0062572896,0.12588534,0.047475416,-0.006749718,0.058134437,0.012796347,-0.07160059,-0.06895425,0.05468312,-0.041356202,-0.030739095,-0.028772006,-0.015212007,0.023565318,-0.035603933,-0.04392193,-0.096494265,0.11038192,0.053971317,-0.06461752,-0.0059647416,-0.03093351,0.033715088,-0.09359289,0.11507273,0.056128148,-3.4181273e-08,0.022132223,-0.04113845,-0.012582718,-0.07691347,0.0014788633,-0.008516448,0.025620246,0.010753746,-0.0017029722,-0.02383141,-0.06711646,0.059815206,-0.00642652,0.017502759,0.06671353,-0.030483695,0.031111144,0.04773153,-0.0053158887,-0.034227442,0.0017019588,-0.0059098853,-0.104605444,0.033137098,-0.0076424526,-0.0074306843,0.03007824,-0.010559987,0.03113975,0.058703344,0.016908534,0.09689192,-0.03495446,-0.053865973,-0.034857,0.10787283,-0.07416878,-0.07985675,-0.00075022166,0.021536624,-0.008266181,-0.018429628,-0.01548232,-0.008555528,-0.09161853,-0.010323219,0.011744078,-0.00778392,-0.032410845,0.00783508,0.03739634,0.028165072,-0.015054138,-0.05636713,-0.08278749,0.054771956,0.020680888,-0.028419888,-0.038074456,-0.076126,0.012603699,-0.041206263,0.2016053,-0.03701175 +1.3.1.125,"The enzyme, characterized from the marine bacterium Vibrio harveyi, enables the organism to utilize acrylate as the terminal electron acceptor for NADH regeneration under anaerobic 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+1.3.2.4,"Contains a non-covalently bound FAD cofactor and four heme c groups. The enzyme, characterized from the bacterium Shewanella frigidimarina, is a soluble periplasmic protein that functions as a terminal electron acceptor during anaerobic growth. The direct electron donor is the membrane-bound tetraheme c-type cytochrome CymA (EC 7.1.1.8, quinol---cytochrome-c reductase), which receives the electrons from the membrane quinol pool.",384,1.0,-0.09515604,0.03801121,-0.10991113,-0.034265876,0.036821254,0.014777227,-0.008310866,0.09255565,0.009500163,0.0065268483,0.030855231,-0.1250873,-0.062703244,0.060207594,-0.044403587,-0.022916956,-0.074064106,-0.07424074,-0.014433411,-0.040945154,0.007388485,0.025924418,-0.010587381,-0.07297376,0.025223266,0.030747911,-0.00095856865,-0.022183262,-0.02680162,-0.029520473,-0.070199445,0.06840611,0.038344912,-0.004223442,0.029646454,0.10055266,-0.022437068,-0.09079193,0.03242081,0.0013737151,0.041884363,0.046192225,0.042613722,0.0029192981,0.014884282,-0.000387999,0.114393316,0.04756699,0.00791195,-0.055605702,0.043739967,-0.038750473,-0.039419826,0.056423955,-0.017024001,0.06375483,-0.012289033,-0.098308325,-0.010234422,0.016183197,-0.003886916,0.021537125,-0.008319603,0.021199616,0.04391291,-0.09994862,-0.00034719304,-0.06919097,0.0019416183,-0.040569782,-0.022103904,-0.045027345,6.728006e-05,-0.016658137,-0.0036118354,0.053772498,0.044455465,-0.02670784,0.051665433,-0.013877169,-0.018335592,-0.03733583,0.03461202,0.11906939,0.051465195,-0.02518051,0.012782218,-0.019616645,-0.015536282,0.02672869,0.0051211813,0.033517864,-0.03213135,-0.027543835,-0.17102304,0.038258824,0.037522983,0.03418952,0.0071386583,-0.017017232,0.06129938,0.08924271,0.03638083,-0.036907602,-0.05521412,-0.05919546,0.03342304,0.122892715,0.038079567,0.008363039,0.027876653,-0.019210473,0.024405751,-0.053162575,0.0070486167,0.06375866,-0.023126101,-0.0835272,0.041006636,-0.022865001,-0.05934252,-0.03680881,0.017493943,0.043478087,0.052548304,0.020479329,-0.16158032,2.419662e-33,0.03730285,0.025880707,0.011852323,-0.0044895676,-0.043215036,0.021751024,-0.063251235,-0.028257003,-0.03821019,-0.029077131,-0.07808409,-0.011571486,0.062871985,-0.0022399845,-0.030406661,0.0027444942,-0.08452904,-0.05703048,0.045000736,0.0066373227,0.08046642,0.082146294,-0.013535406,-0.035276055,0.12715739,-0.0040940503,-0.020680713,0.03966206,0.009039544,0.021331333,0.039799422,-0.041093316,-0.042419758,-0.022775657,0.029075302,-0.0015546707,-0.065745674,-0.0016053269,-0.052686986,0.031663433,0.0073385476,0.04210543,0.02460765,-0.026305873,0.078969605,-0.07724708,-0.07099576,0.045609467,0.009656106,0.030309927,0.029428221,-0.026684517,0.087678485,-0.055934537,-0.100035265,0.055936787,0.020622991,0.056673948,0.04457606,0.05073023,0.034350175,0.12286886,-0.10210772,0.11719281,0.047638856,0.07491272,0.009773324,-0.08565432,0.02411838,0.113848664,-0.10359685,-0.03583829,0.067530476,-0.016046247,0.019240037,-0.024185985,-0.053531524,-0.0103056105,0.022854159,0.002779909,0.038527537,-0.09218176,0.06408201,-0.090901576,-0.039095916,-0.08074374,-0.015698727,-0.054687437,0.015160448,-0.016151108,0.10077847,-0.07651158,-0.026765209,-0.003823008,-0.017453453,-3.0875957e-33,0.091159925,-0.080146454,0.033143897,-0.09515169,0.0052437475,0.079140835,-0.00905383,0.011413796,0.04772019,-0.018939987,0.081349246,0.03260341,0.043657526,-0.0049687503,0.031766508,-0.03761063,-0.068280555,0.009865791,0.018565083,0.04264652,-0.074682906,-0.0012086013,0.057949424,0.009781162,0.003595942,0.01411737,-0.041262604,-0.017109916,0.0008766475,-0.035574947,-0.058524247,-0.02596507,-0.05047695,-0.059753668,-0.06358753,-0.04564551,-0.032975595,0.02212993,0.07621772,0.02067319,0.0138277775,0.02381107,0.057217818,0.044283796,-0.006608572,0.041067913,-0.09588373,0.0054118023,-0.0053193937,0.020267062,-0.013902022,-0.0063239876,-0.007945351,0.014803904,0.07187952,0.044232644,0.05777378,0.0050710253,0.032648772,-0.0054362905,-0.06792747,-0.13804287,0.06332444,0.003963805,0.06276884,-0.0023295132,-0.048180558,0.07117544,0.013268958,0.034029003,0.05330321,0.077554494,-0.02343803,0.023488333,-0.045764145,-0.009296905,-0.026602225,-0.013028402,0.04276721,0.020095432,0.016717931,0.014091971,-0.009171841,0.012826242,0.034719393,-0.09806056,0.023871459,0.08021603,0.024633383,-0.011167276,0.016999042,-0.0073086205,0.028194578,-0.002837824,0.054435924,-4.3621235e-08,-0.018062823,-0.023298174,0.008889604,-0.021549048,0.041754186,0.04482469,-0.010903567,-0.08157012,0.09017179,0.048445936,0.013598655,0.13094953,0.0040364796,-0.039184622,0.019829692,0.03967985,-0.061254065,-0.058752496,-0.002623844,0.023901593,-0.046268005,-0.045366265,-0.09510142,0.0661331,0.031475727,-0.06522403,0.027627291,0.008588992,-0.07451045,-0.005314675,-0.08448012,0.0057467734,0.0035327254,0.0059342426,-0.083476275,-0.0060247527,0.016404435,-0.06961273,-0.082910776,0.033607207,0.07348048,-0.029190034,-0.05843973,-0.026929172,0.015058401,0.02574826,0.052882023,0.0026154972,-0.03064325,-0.01180966,0.018622635,-0.06345071,0.007109752,-0.08560975,-0.072366044,0.025157267,-0.041644227,-0.019109005,0.013281678,-0.004668626,0.08551158,0.025735587,0.15393925,0.0180862 +1.4.2.2,"The enzyme, characterized from the bacterium Pseudomonas putida S16, contains an FAD cofactor and belongs to the flavin-containing amine oxidase family. The enzyme from this bacterium is specific for the c-type cytochrome CycN. The product undergoes spontaneous hydrolysis to form pseudooxynicotine.",384,1.0,-0.122575074,-0.041974556,-0.13807492,-0.034392923,0.06407601,0.06396394,-0.08547215,0.07715133,-0.009257664,-0.058473133,0.05615633,-0.06667641,-0.055854317,0.10011675,-0.08016915,0.01243887,-0.057940517,-0.023789637,0.033380244,0.0038533094,0.028902832,0.07044029,0.006878371,0.061702993,-0.012119898,0.011410985,0.02337053,-0.01703978,0.0022036433,0.025291465,0.032261405,0.009833657,0.076850265,-0.06611753,0.08854374,0.021761578,0.041220024,-0.052199446,0.063238345,-0.027513482,0.024956057,0.061120402,0.03260002,-0.02174209,0.045984846,-0.002864621,0.061653107,0.032306995,0.021928975,0.00021380412,-0.00018356329,-0.058941215,-0.07919348,0.018112801,0.026666403,0.06846791,-0.04391924,-0.10370223,-0.0023016795,0.046834644,0.028215462,0.011361231,-0.041499622,0.05666267,0.04431838,-0.004748862,-0.013447625,-0.057917453,0.03052678,-0.07975437,-0.019169997,-0.09932016,0.012191568,0.03549497,-0.06571493,0.011022914,0.009537283,-0.03333763,0.01645117,-0.009291404,0.0051295627,-0.0647838,0.02041326,0.1409715,0.031142859,-0.06045004,0.030691026,0.009543755,-0.0065978672,0.04407417,-0.016850105,0.017663047,-0.031474847,-0.07995814,-0.062243585,0.038130328,0.05795218,0.07769286,0.036062922,-0.018790584,0.049044065,0.055279955,0.0491925,-0.07942483,-0.04775596,-0.049178947,0.031079749,0.115634575,0.067975685,-0.0042759976,-0.02107749,0.037135124,-0.013615083,-0.08914399,-0.028053055,0.028307576,0.01138585,-0.09561761,-0.05339466,-0.020169253,-0.0014798976,-0.03194561,0.035396736,0.07498948,0.044359833,-0.015026339,-0.15520109,1.7806923e-33,0.072412595,0.0066440627,0.020323984,-0.039838903,0.0036931213,0.016453763,-0.049546793,0.0500214,0.014930357,-0.015227483,-0.07570055,-0.035189305,0.01682919,-0.027868895,-0.046086233,-0.014073114,-0.061785143,-0.093761586,0.073987335,-0.012354984,0.06403378,0.076054744,-0.018144004,0.0047298586,0.08675294,0.024671502,-0.024938786,-0.0014951506,0.010070012,0.02657487,-0.0052680573,-0.0705255,-0.112813,-0.045743268,0.015944835,-0.012113152,-0.04932518,-0.057045594,-0.019727133,0.09229669,0.04186806,-0.026774153,-0.0067644925,-0.011263213,0.1024764,-0.07550666,-0.090974085,0.15167813,0.017165205,0.105761,0.022394579,-0.060769793,0.021246567,0.051375408,-0.09067034,0.037162427,-0.011017981,0.043138538,0.015279871,0.019722255,0.078680895,0.07358064,-0.0722069,0.07615627,0.03208308,-0.011263928,-0.008109481,-0.048786446,0.0065408465,0.06435142,-0.06314019,0.018392224,0.017335812,0.038049795,0.065763995,-0.084177084,-0.04481521,0.043016206,0.048376516,0.01553728,-0.014310858,-0.012154368,0.038330223,-0.048254013,-0.056009654,-0.0133159775,0.01351725,-0.019214127,-0.08309047,0.011745133,0.062993765,-0.15990558,0.025602708,0.055830766,-0.016865632,-2.2573494e-33,0.018331394,-0.10215301,0.052390654,-0.09336106,0.015704792,0.027342284,-0.007897629,0.00524771,0.048814848,-0.017299868,0.07857095,-0.031671736,0.040716816,-0.016585948,0.0071864496,0.0305319,-0.03231511,0.033211797,0.005174849,0.029716056,-0.017064454,0.015406841,0.02143224,0.02510647,0.065715164,0.032617025,-0.008586054,0.049788397,0.043512262,0.077578366,-0.05193502,0.044696573,-0.06363329,-0.05276362,-0.044617996,0.03046495,-0.053439066,0.019588806,0.04520628,-0.014155647,0.031102724,0.036380284,-0.0267326,0.08535391,0.00077832496,0.075737,-0.13622607,-0.017697051,0.0423133,-0.05318772,-0.0058901836,-0.006230421,-0.019834656,0.05056486,0.04783902,0.0366014,-0.0007773573,0.039533053,-0.038953926,-0.03741327,0.015746897,-0.10374585,-0.019748028,0.003717611,0.07446227,0.007887182,-0.05281909,0.060128927,-0.03590493,0.00048166967,0.037180748,0.005661672,-0.051119246,0.06674124,-0.07298618,-0.015953997,-0.010654794,0.012190097,0.03894116,0.03156212,0.07103767,0.021981746,-0.00446002,-0.025177453,-0.0044831224,-0.04155875,-0.00039158383,0.06623956,0.007570538,-0.030072682,0.013349237,0.044979732,-0.0019983964,0.0105023775,0.031531807,-3.2761616e-08,0.022242155,-0.09318877,0.067818865,-0.013311214,0.028314622,0.060177367,-0.011974899,-0.0658255,0.0024251842,-0.08852792,0.014895634,0.07274612,-0.042079486,-0.05332286,0.015336689,-0.027781485,-0.08301494,0.002265103,-0.01192142,0.017901413,-0.04215958,-0.0022793352,-0.070573315,0.020951778,-0.015775383,-0.040496405,0.02686132,0.03977611,0.0018976456,0.025884917,-0.01148188,-0.040639006,-0.0065573365,-0.016304478,-0.14664117,0.002389271,0.055990122,-0.054763593,-0.061448045,-0.009399478,0.014785758,-0.06712571,-0.09235011,-0.013242337,0.04743835,-0.025226584,0.022422906,0.0048397896,0.0014452233,0.00014452948,0.023855451,-0.043813694,0.0037205752,-0.042999923,-0.04822539,-0.020620648,0.0387695,-0.06677996,-0.048383057,-0.019765899,0.0149656115,0.068951786,0.17801525,0.05376959 +1.4.2.3,"Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacteria Pseudomonas sp. HZN6 and Pseudomonas putida S16, is involved in nicotine degradation.",384,1.0,-0.054783486,-0.0020595693,-0.07665004,-0.08053958,0.06778498,0.029608456,-0.077574834,0.10068916,0.02993172,0.0037121628,0.008573538,-0.0037038277,-0.114300005,0.06055505,-0.028857447,0.0056102844,-0.061208073,0.03861997,-0.055178326,0.032245204,0.056455497,0.11610335,-0.03710701,0.026378112,-0.0021634286,0.040171687,-0.005196004,-0.0010252952,0.05099543,0.04857134,-0.012076838,0.04333338,0.008811892,-0.019190516,0.04943691,0.0025045623,0.028291313,-0.0097996695,0.0813785,-0.03599224,0.04099249,0.03513685,0.03442888,-0.013244003,0.033356395,0.010665034,0.016980387,0.003460316,-0.007951104,-0.061201274,0.0462467,-0.03860311,-0.01868604,0.057640623,-0.02726269,0.024354875,-0.053182647,-0.037907902,-0.010816721,0.021260902,0.03351264,-0.034608126,0.019425778,0.005777594,0.091868736,-0.040501833,0.028567325,-0.06711157,0.018854104,-0.013081609,-0.07617958,-0.043718923,0.014135751,0.013514791,0.03666796,0.046512768,-0.111248635,-0.03035433,0.088304974,-0.07155783,0.04585635,-0.03936548,0.075777575,0.14158382,0.007167072,-0.07011392,0.07955986,0.014766775,0.0201648,-0.038358897,-0.010874503,0.010150919,-0.016165959,-0.03350221,-0.19481541,0.056303363,0.05087941,0.02126826,-0.028017977,-0.024717605,0.030590538,0.085228726,-0.006381681,-0.06265747,-0.027371181,-0.011346811,0.009420845,0.066525765,0.037026998,0.04824503,4.998849e-05,0.044282634,0.00973382,-0.04870581,-0.0038188638,-0.022298299,0.0027147422,-0.04652973,0.008375711,-0.03425854,-0.05058036,-0.039274298,0.026935235,0.082188115,0.10396313,-0.05303715,-0.08612966,1.9627914e-33,0.039315067,0.012609905,0.00036889868,-0.008454292,0.045381453,-0.03606772,-0.04213485,0.0061910464,0.016212026,0.01772099,-0.038848273,-0.06947057,-0.003958009,0.01774887,0.00977732,0.051719002,-0.065571696,-0.10028148,0.08826561,-0.06781559,0.045449857,0.08341986,-0.024980323,0.07602383,0.0295378,-0.022042405,-0.06431461,0.028386109,-0.03553754,-0.017573196,0.06467379,-0.009868186,-0.11440514,-0.0706394,0.040607505,0.06254202,-0.030905023,0.009901025,-0.06175894,0.04160379,0.085453846,0.004610571,0.047400046,-0.024259219,0.058298584,-0.07886934,-0.08454756,0.062499322,0.035258554,0.07474832,-0.05300907,-0.066825666,0.054595552,0.03352345,-0.08622425,0.008479121,-0.018906014,-0.0023853725,-0.018731259,0.030396612,-0.0056967093,0.00011845186,-0.06690352,0.104282394,-0.011075124,-0.015577071,-0.0014913649,-0.10080199,0.03660149,0.09846869,-0.045319524,-0.0056740134,0.042716466,-0.0019741948,-0.003742343,-0.11907994,-0.019155229,0.014063143,0.0023646909,0.06707147,-0.026462344,-0.09048493,-0.047457602,-0.07180983,-0.084713496,-0.051446673,0.042486567,-0.092420585,0.016219787,0.007782296,0.038593277,-0.11054973,0.0075110695,0.03677934,-0.020411957,-2.1629765e-33,0.011613728,-0.04059587,0.13666809,0.00913591,0.0051005343,0.057493225,0.009161049,0.034203324,0.030956782,-0.08807315,0.0826838,0.0065266583,0.06060302,0.023281604,0.03394318,0.10299542,-0.04361596,-0.0075759883,0.045577843,0.033789936,-0.054691643,0.03673986,-0.03459247,0.09593162,0.03364193,0.02265873,0.006524213,0.03290409,0.01073834,0.024728332,0.025886897,0.05233695,-0.071020044,-0.024774142,-0.098513715,-0.044744942,0.022526711,0.0004009495,-0.06120174,-0.04022089,0.063686274,0.011066231,-0.060924612,0.07887692,0.02452508,0.018093478,-0.08272908,0.013511371,0.059407026,-0.049260303,0.05082777,0.0095357,-0.056179676,0.029635219,0.10608199,0.023140268,-0.041788213,0.028949762,-0.040755175,-0.025167368,0.003134721,-0.090324596,-0.05231815,-0.0412856,0.0871075,0.0268608,-0.023729647,0.08142448,0.028013363,-0.0033422797,0.05801354,0.047591798,0.03127119,0.012095052,-0.067577094,-0.052863877,-0.007599258,-0.045303028,0.022093542,0.016707664,0.041101832,0.021600684,-0.045411035,-0.0044979868,-0.034516618,0.00033365804,0.03892843,0.09266814,-0.051786423,-0.0065450068,0.0070175203,0.014251733,0.02246504,0.0093075,0.029583184,-3.0896146e-08,0.092962205,-0.07517089,0.011892041,-0.05922044,0.008594998,0.055354588,0.05109745,0.04134126,-0.0048858873,0.023622803,-0.008265702,0.09675955,-0.054605562,0.005550933,0.04313014,-0.016304646,-0.110031605,0.044319104,-0.091239445,-0.024004536,-0.103552565,0.047130175,-0.040061355,-0.008300643,0.0023728732,-0.006772728,0.03229505,-0.014913867,-0.00088428997,0.009495865,0.016499454,-0.030286396,0.06133829,-0.016137542,-0.10034994,0.009760447,0.04751674,-0.071287595,-0.043119393,0.021770073,0.0039360486,-0.03307588,-0.11429773,-0.032772567,0.029612625,-0.029820343,-0.029250659,0.05146591,-0.04923423,-0.02832051,0.02226408,0.013327554,0.006663567,-0.05070274,-0.12324915,-0.0439656,-0.03168883,-0.0025578046,0.0023194451,-0.027799683,0.045724668,-0.024285987,0.120131515,-0.018816488 +1.4.3.27,The copper-containing enzyme has been isolated from the plant Heliotropium indicum. It is involved in the biosynthesis of the pyrrolizidine alkaloid (-)-trachelanthamidine which acts as a secondary metabolite for the defense against herbivores. The oxidation of sym-homospermidine proceeds in three steps and results in a cyclization.,384,1.0,-0.043383654,-0.0015026147,-0.11616365,-0.009704288,0.06126852,0.056921914,-0.061504163,0.02836515,-0.03740489,-0.016545825,0.11667559,-0.028218292,0.018454593,-0.03629008,-0.07686676,0.0025425258,-0.059321053,0.011521323,-0.04199519,-0.05559723,-0.055963706,0.033605456,0.01965604,0.0049394025,-0.009386842,0.090169206,-0.065717064,-0.0038486188,0.0015217442,-0.025643531,0.013878614,0.013997145,-0.003169636,-0.015011789,0.034072906,0.009896899,-0.0910263,0.060462713,0.07673537,0.01661429,0.030008728,-0.040397618,-0.003763449,0.017886447,-0.09177634,-0.11008952,0.020128764,0.03018273,0.032033864,-0.007703832,-0.04987181,0.078565024,-0.056445774,0.033956323,0.023708075,0.018222788,-0.0059053022,-0.024899596,-0.040035807,-0.023803087,0.07357734,0.00050423795,-0.050641038,0.024913935,-0.05574231,-0.026864694,0.008114179,-0.053026978,0.09646942,-0.045158338,-0.04340828,-0.114204355,-0.008754184,0.00696032,0.009845,0.12882447,0.027202867,-0.0455963,0.0068815365,-0.0135584725,0.04531706,0.01447445,-0.0033406815,0.04690718,0.06103722,0.02398609,-0.004620578,0.038437486,0.0039109862,-0.014459837,0.11311634,0.04561053,-0.034066856,-0.05548502,-0.06644698,0.08050432,0.00938279,0.043719154,-0.0274187,-0.03303779,0.02312359,0.023921974,-0.06428306,-0.08362275,-0.037558764,0.010605517,-0.05264049,0.01039201,-0.019013913,0.020792758,-0.013948491,0.022316912,-0.058223814,0.0016584696,0.019537115,0.10807648,0.021667264,-0.07907632,-0.03933762,-0.032055303,-0.034406852,-0.0190138,0.03861438,0.059575934,0.034287736,-0.044157512,-0.03988887,2.7121786e-33,0.024047894,0.039852384,-0.009849804,-0.017122129,0.11052096,-0.013559065,-0.04448235,0.03746789,-0.027202275,-0.01722009,-0.09618606,-0.038925756,-0.011016363,-0.037168007,-0.03319902,-0.034193166,-0.060155552,0.0019083791,0.12161235,-0.08726367,0.009902687,0.07474079,-0.07277036,0.01478557,0.012417295,0.053733278,-0.016129693,-0.0025777053,0.06665375,-0.0019268867,0.017390395,-0.07447092,-0.042272028,-0.016664123,0.08277284,-0.013942469,-0.08937639,-0.020592649,-0.026342863,0.11479199,0.0012885773,0.068644725,0.024768423,-0.0037541403,0.0032313927,-0.039818533,-0.08535069,0.1679094,0.0276153,-0.021487381,0.053526085,-0.029758671,0.14561732,0.06328972,-0.05255854,0.05394975,-0.0036326828,-0.037645616,0.043047886,-0.013993144,-0.019235106,0.00267712,-0.050799195,0.039392445,0.062326122,-0.002897875,-0.086515956,0.006826087,0.01656518,0.061814282,-0.039894328,-0.036913313,-0.042793263,-0.012178105,0.046459265,7.428307e-05,-0.051197086,0.050527226,-0.019653209,0.014973372,-0.02869436,0.0125211775,0.02210341,0.0070644305,-0.016884077,-0.048057325,-0.102945454,-0.017429974,0.043047,-0.032212064,0.0381482,-0.02789308,-0.05260778,-0.0231067,0.029369768,-3.8325605e-33,0.019003544,-0.02464474,0.049159005,-0.013755375,-0.0204382,0.05014209,-0.022873968,0.026755074,-0.0028909247,0.0017162926,0.004000817,0.053345706,0.05775565,-0.056896456,-0.025904557,0.0047724694,0.020827232,0.1395964,-0.018014127,0.05379682,-0.12879421,-0.007474204,-0.047022246,-0.009851629,0.0022839303,0.0024628537,0.035282873,-0.0011756745,0.049390856,0.022710402,0.066574834,0.050528843,-0.0633904,-0.04200624,-0.02368864,0.053540897,-0.051356282,-0.008199365,0.013710828,0.10457291,0.027705643,0.003334535,0.03267052,0.028281936,0.065846264,0.044499442,-0.050584227,0.004634829,-0.112659246,0.0093412725,0.088883474,0.11904633,0.0077569247,0.022000328,0.09853149,0.059602525,0.067139216,-0.023777306,0.022993436,-0.06658467,0.011577614,-0.016825803,-0.1335716,-0.00038123227,0.005707824,0.07392381,-0.043694776,0.09516186,-0.0300479,-0.0330888,0.05019052,-0.0058673015,0.006236423,0.043541607,-0.03831103,0.03174653,0.013109258,-0.022097373,0.05710325,0.07009949,0.01192876,-0.051615477,0.059166852,-0.10308483,-0.07617711,-0.07087023,0.02385988,0.1152484,-2.893297e-05,-0.0101284245,-0.005748474,-0.04102235,-0.037188977,0.10803765,0.11087957,-4.005045e-08,-0.0006039638,-0.060271185,0.056605894,0.024875196,-0.015509025,0.055491835,0.024146335,-0.06943777,0.040128615,-0.015111861,0.011432621,-0.0066207102,-0.020761281,0.030797636,-0.00028321927,0.03153447,-0.002290415,-0.024212256,-0.0149366,0.0066007893,-0.12322713,0.04111592,-0.06020506,-0.06384602,0.017313363,-0.051304277,0.04529605,0.0043251137,-0.04558127,0.034897286,-0.019570632,-0.01659886,-0.058821134,-0.02835723,-0.085671626,0.011496374,0.026145304,-0.030498857,0.084420234,-0.03162652,-0.046289437,-0.03430807,-0.06651425,0.010181233,-0.031259574,0.012048821,-0.019533213,0.021183692,-0.0048537715,0.0062223417,-0.041409902,0.036733307,0.046073556,-0.14192382,-0.056905065,0.021460315,0.0024575435,-0.013408677,-0.07123715,-0.098356664,-0.05249491,-0.005601114,0.15983494,0.031180862 +1.14.11.80,"The TET proteins mediate iterative oxidation of 5-methylcytosine in DNA (5mc) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC are recognized by EC 3.2.2.29, thymine-DNA glycosylase (TDG), which excises them, leaving an apyrimidinic site. Coupled with the base excision repair (BER) pathway, these activities result in a cytosine demethylation pathway.",384,0.99999994,-0.05399348,-0.001210118,0.04890451,-0.05031962,0.052011788,-0.028973505,-0.0045867437,0.02459192,-0.022580449,0.08178786,0.02733975,0.12154311,-0.03662749,0.019635804,-0.039711166,0.049438167,-0.13479976,0.02177805,-0.02514949,-0.10287042,-0.038961235,0.0583265,0.037081446,-0.009805966,-0.020817455,-0.023453046,-0.004416222,0.059537645,-0.043623924,-0.062310204,-0.034643523,0.022210551,-0.08798696,-0.030618846,-0.037193757,0.11789057,0.009453579,-0.0539466,0.019969871,-0.025606394,0.04217188,0.0069628935,-0.0879132,0.028549388,-0.06071254,0.014553853,0.056787267,-0.047438815,-0.03355051,0.050263114,0.035750926,0.04728825,0.03858552,-0.023651596,-0.050068613,0.08740071,-0.004371509,0.060382195,0.0087222755,0.03255891,0.0427459,-0.035872977,-0.013270247,0.01659516,-0.0046277563,-0.021912541,0.09283173,-0.050983757,-0.06100562,-0.00092735974,-0.0484946,-0.0641896,0.021029042,-0.011165045,-0.070418835,0.03920201,0.020298911,-0.13356958,0.004570021,0.06364953,-0.06141977,-0.02156077,0.07284948,0.025372798,0.008004621,-0.0434452,-0.02281384,0.0538081,0.059422944,0.06027124,0.014765615,-0.009518167,0.0015652573,-0.016149966,-0.060753617,0.003127729,0.040473994,0.007011263,-0.0083188815,-0.079531856,-0.014303401,-0.006972306,-0.0955513,-0.011343895,0.0361808,-0.0061273454,0.04277389,0.023902057,0.019373765,-0.050656356,-0.070454605,0.07669747,0.024896823,-0.017492559,-0.038578965,0.06157047,-0.015606211,0.022128515,0.02099772,-0.03246335,0.016308233,0.028097607,0.016636014,0.014173633,-0.080414705,-0.057249993,0.001805991,3.9626194e-33,0.006180472,0.08874733,0.06652942,0.10184215,0.01299102,0.057370253,0.033810943,0.014715685,-0.030727286,-0.022600276,-0.004783923,-0.04928982,0.057905067,0.037931617,-0.06327336,0.028309848,-0.12322898,-0.004770114,-0.014681124,-0.06681255,-0.015593324,0.056892626,-0.045528796,-0.031927723,0.0051756664,0.06725416,0.0054589016,0.04404831,0.058869634,0.0026903723,-0.08277696,-0.04869849,-0.004277473,0.0013825624,0.08651868,0.10201923,0.064510524,0.035323918,0.066876255,0.08933571,0.0057980763,-0.01987614,0.009460347,-0.06222074,-0.03824806,0.03395271,-0.036815986,0.00012120609,-0.06029763,0.0019070203,0.058616538,-0.005831743,0.04941374,-0.0026668916,-0.047549106,0.053419422,-0.04095834,-0.040256135,-0.01788285,0.10998374,0.02669535,-0.05292432,-0.016278991,0.006189699,0.033803377,-0.013373857,-0.049152397,-0.019180275,0.013988012,0.05280528,0.017895993,0.03420911,0.14311193,-0.0062171505,0.010003155,0.061685223,-0.037487917,0.012457377,-0.024172787,0.039900333,0.0042094425,-0.021442834,-0.017323615,-0.046342388,0.011417053,-0.016718961,-0.0108640045,-0.0007301654,0.065034,0.03928527,0.07683604,-0.12275462,0.029090105,-0.06738593,-0.09384692,-5.2985103e-33,0.09283167,-0.020112352,0.08367633,-0.031576566,0.0014898506,-0.100110255,0.03533116,0.07056158,0.008886855,-0.047606416,0.06617464,-0.02854558,-0.032909416,-0.007220359,-0.03373279,-0.027708054,-0.011536528,0.0456513,-0.028197734,0.010436545,0.014784579,0.024118675,-0.07340773,0.06185593,0.028456118,0.05875777,-0.07408977,-0.003133282,0.08059548,0.020654054,-0.07804576,-0.021259306,0.0095263235,0.016589701,0.13247941,0.06094619,-0.07168726,0.007442919,-0.012678381,0.001748065,-0.036404148,0.006389231,-0.044435773,0.08647349,0.021892069,0.05227199,-0.098294795,0.051950358,0.005266674,-0.0038456367,0.021598013,-0.031469095,-0.0469065,0.030491333,0.05336318,-0.0135822315,0.0470536,-0.060390722,-0.027530365,0.018631639,0.005960381,-0.00788859,0.040219277,-0.0013809211,0.026601626,0.02691754,-0.028552571,0.047152117,-0.0015061,0.00089518033,-0.019856256,0.009279805,0.04588312,-0.04492954,-0.029212108,-0.04286394,-0.07973899,0.0028547726,-0.0117016435,0.002073067,0.03603768,-0.048484523,-0.007625742,-0.05301178,0.07926843,0.02110056,0.017895853,0.116277955,0.006711582,-0.03925884,-0.0834883,0.01140259,-0.017084777,0.08235272,0.019994745,-4.469347e-08,0.039646305,-0.13890159,-0.015967358,-0.056990553,-0.054006595,0.08126356,-0.0073108757,0.05912001,0.10993144,-0.042252745,0.007187659,0.055101518,-0.01788236,0.024571657,-0.088889845,0.010111755,-0.1292157,-0.008994253,0.04224796,-0.022968736,-0.18445724,0.064624675,-0.043933395,0.039564136,0.027020378,0.0873005,-0.025029123,0.04496278,0.01617368,-0.08365696,0.045966048,-0.030929359,0.0047508683,0.053452715,-0.048346557,-0.017145554,0.038031213,0.008093803,-0.036183298,0.012624371,-0.072248146,0.013951346,-0.056445763,0.02561346,0.02810027,-0.07850058,-0.04757334,0.04821358,-0.03568259,-0.09627639,-0.05358888,0.01670279,-0.07071736,-0.07738276,-0.05323671,-0.014315059,-0.03846752,0.058318112,-0.07525952,-0.038311053,-0.07064298,0.023479577,0.138461,-0.076134436 +1.14.11.81,"This fungal enzyme is involved in the biosynthesis of quinolone compounds. it catalyses two oxidation reactions: the first reaction results in a desaturation; the second reaction is a monooxygenation of the double bond, forming an epoxide. The enzyme is also active with 4'-methoxycyclopeptine.",384,1.0,-0.059769165,0.037359755,-0.080260895,-0.09521829,0.039614465,-0.048600834,-0.028026832,0.04105728,0.040187128,0.02917325,0.05071989,-0.02757369,-0.015139558,0.04832736,-0.07313592,0.090478495,-0.0748443,-0.012243664,-0.0026634727,0.011869373,0.05319193,-0.007680894,-0.033808753,-0.0063905967,0.06950127,0.0050055203,0.062428646,0.05183634,-0.048252597,0.0033530553,-0.0274034,0.019507566,-0.0021543452,-0.03325421,-0.014715612,0.07514226,-0.04289063,0.041497,0.10767856,0.05903953,-0.018809669,-0.009444428,-0.018065222,0.03821922,0.057897415,0.004197327,-0.008040636,0.06202677,-0.0037524507,0.0065549547,-0.051017553,-0.0032283966,0.0069819554,0.013259539,0.053060055,0.036976654,-0.061288457,-0.02057527,-0.009289259,0.042724855,0.03116489,-0.018722951,-0.043739803,0.008489821,-0.01593598,-0.045095883,0.00808762,-0.020946503,-0.025200326,-0.09758151,-0.04452744,-0.03397018,0.01439451,-0.05001346,0.057290968,-0.0041938107,-0.04985722,-0.025052857,-0.013735971,0.024251726,0.051507346,0.01827403,-0.018540943,0.07054876,0.08095375,-0.0031190116,0.04710776,-0.005710369,0.03213236,0.079061806,0.05293047,0.00156717,0.0004893745,-0.058703817,-0.049642824,0.07252933,-0.0130505115,0.07721424,0.023700176,0.020175034,-0.0017151326,-0.030120283,-0.034708653,-0.088049605,-0.051999774,0.019777726,0.087413214,0.10479925,0.03088867,-0.016465643,-0.037481707,-0.004173338,0.03411435,-0.030710818,-0.025287038,0.105123736,0.08236429,-0.0507933,-0.040025815,-0.029849513,0.016954618,0.010014219,-0.0210965,-0.046709955,-0.034582883,0.01036747,0.0027494933,2.5647064e-33,0.02508171,0.09353962,-0.06062069,-0.0015414438,0.04661498,0.01975139,-0.0549299,-0.009478319,-0.104436845,-0.054394174,-0.07432465,-0.011485568,-0.023043027,0.03180883,-0.067693375,0.048229985,0.03340185,-0.020734712,0.0563107,0.0134184705,0.055597927,0.04128425,-0.086707376,-0.0010514813,-0.016090168,0.06594529,0.021566797,0.0077258674,0.0019375036,-0.023048742,-0.00069042586,-0.0073349033,-0.06220614,0.020295508,0.04156749,-0.02577661,0.0020437245,-0.005179138,-0.06393036,0.03857858,-0.025282528,0.058750555,-0.03284515,-0.050546013,0.044630777,-0.048298314,-0.027926492,0.100486964,0.08470929,0.032220576,0.07756148,0.03684874,0.065648,-0.006527929,-0.09160512,0.04468221,0.020512562,-0.05142887,0.05060179,-0.026834019,-0.04405419,0.034745608,-0.03877882,0.008641496,-0.0020928557,-0.0030255027,-0.040210012,-0.074858814,0.03334936,0.08086484,-0.04690658,-0.017947726,0.0017768309,-0.031956848,0.011362471,-0.012113723,-0.052777782,-0.031794965,0.026254399,-0.024641288,0.016227702,-0.0129896365,0.06520916,-0.037293542,-0.043900527,0.010370716,-0.022420354,-0.07292203,0.029177887,0.057100665,0.029611452,-0.04674403,-0.080303095,-0.023716815,0.08679994,-2.9721124e-33,0.12176383,-0.104034126,0.0020225619,-0.0685458,-0.03619868,0.087604,-0.03568413,-0.03762614,0.008898899,-0.03524715,0.048680972,-0.09376046,0.028588936,0.034800112,0.01391089,-0.0072163893,0.010063466,0.084543906,0.0064705815,-0.02625364,0.032195196,0.07647937,0.01834624,0.041118316,0.068450704,0.021533119,-0.018749336,0.08890062,0.052922912,0.070582606,-0.09430954,-0.045541152,0.03483073,0.011549242,-0.010816716,0.13908409,-0.041737724,0.030666033,-0.015889302,-0.019158471,-0.01589129,-0.07551394,0.011958792,0.06549647,-0.033544272,0.037394255,-0.066456944,0.061523326,-0.00029764217,-0.08489392,0.05909943,0.09680962,-0.03396622,0.00924472,0.08498372,0.043138783,-0.026299786,-0.062190346,0.048922528,-0.05785256,-0.047673605,-0.08384843,-0.036684036,-0.054684903,0.05801004,0.04372281,-0.06947701,0.06125678,0.044588625,-0.038675267,0.07838022,0.059623595,-0.019530024,0.002901657,-0.015857918,-0.042607583,-0.08768995,-0.07886068,-0.0030154125,0.07853929,0.004487759,-0.036715787,0.013625964,-0.006361763,-0.15199043,-0.13312654,0.043361884,0.13917035,-0.061997276,0.005016477,0.026670104,0.07069613,-0.06427485,0.05170247,0.08286165,-3.6285773e-08,0.008749489,-0.041044742,0.056216136,-0.027685648,-0.065898,-0.0018880857,0.051598046,0.050455198,0.035252046,-0.030927837,-0.017030653,0.10722954,-0.002126028,0.027659725,0.059039813,0.024972765,-0.032957442,-0.0029522276,-0.03898592,0.027661951,-0.036100347,-0.0023052583,-0.07292835,-0.020680243,-0.057068277,-0.08164395,0.033250675,0.042551167,-0.017627249,-0.010805287,-0.06100342,-0.00084252574,-0.02463784,-0.06294291,-0.10368646,0.06776071,-0.0560045,-0.047277752,0.014991984,-0.0908348,0.0054946844,-0.07667581,-0.13109007,0.024020886,-0.043430638,-0.056906242,0.020300105,-0.022746969,-0.021517308,-0.034049504,0.07174868,0.008782047,0.045547202,-0.026011785,-0.097413026,0.034095574,0.029801551,-0.004342672,-0.046694107,-0.036800206,-0.0072129006,0.010646752,0.20254104,-0.024223646 +1.14.11.82,"Requires iron(II). The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin.",384,1.0,0.0052605025,0.05485161,-0.118032694,0.07485075,0.12573476,-0.013586492,-0.07296783,0.03742618,0.037522577,-0.106848896,-0.00552355,-0.07896389,-0.08010369,-0.002830389,-0.044794396,-0.018616261,-0.01102293,0.03574048,-0.033490665,-0.019417731,0.08861667,0.03757866,-0.004863329,-0.0051772613,-0.05732525,-0.01227295,0.051056325,0.008781422,-0.037992597,-0.029631505,-0.07412299,-0.040670272,0.06930163,-0.022446753,0.033130392,0.08474262,-0.019962871,-0.04199956,0.0081834495,-0.024028335,-0.0029402666,-0.08646484,-0.034308687,-0.030691722,-0.06064065,-0.026648864,0.039399963,0.024529887,0.006064582,0.08186477,-0.10983022,0.02385602,0.0051437058,-0.020507695,-0.002893264,0.06106434,0.037072532,-0.06727195,-0.05441142,0.008512335,-0.0031433096,-0.05679651,-0.023235206,-0.018878957,0.016196119,-0.04322007,0.02629448,-0.057834733,-0.06372271,-0.021781312,-0.019411009,0.0028611002,-0.055703666,-0.025602713,0.05977212,0.072484896,0.020389413,-0.05918142,0.09927837,-0.0068649934,0.016891347,0.044295147,0.022746453,0.06329596,0.06532765,0.0069764787,0.017633088,0.016578877,-0.010729337,0.1109048,0.03265648,0.008322436,-0.0029002486,-0.0068178666,0.053897824,0.08292876,0.0683019,0.0546414,-0.004494874,-0.02226661,-0.047835182,0.0006289643,-0.0114356,-0.043661386,0.046414305,-0.02480362,-0.042792846,0.082540095,0.045771323,0.003832266,0.057684492,-0.053739253,0.06657445,-0.040903047,0.062015302,0.026727045,0.06961136,0.003262158,-0.037189968,0.039676066,0.07027109,0.06491334,0.017255718,0.030202016,0.000758052,-0.0070592207,-0.07060727,4.6190885e-34,0.058930367,0.06364992,-0.03447734,0.043816775,-0.030262223,-0.014943978,-0.082506455,-0.031771332,-0.04408333,-0.015428771,-0.09541274,-0.08760773,-0.054490272,0.012442518,-0.034376923,-0.032476727,0.067254744,-0.029845152,0.048903916,-0.005636586,0.05751357,0.031066623,-0.01128185,-0.006568948,-0.020106643,0.10760027,-0.013067958,0.023250494,-0.014258697,-0.0061447984,0.08260355,-0.10253983,-0.08087035,-0.0190525,0.12615176,0.010769728,0.024073912,-0.016869282,-0.10341279,-0.016972104,0.036709756,0.057953347,-0.023546465,-0.05181123,0.06954693,-0.07482254,-0.014729207,0.10983013,0.023657288,0.047009144,0.0111163305,0.03531123,0.11447397,0.011485042,-0.012186346,-0.052673813,-0.033577785,-0.004073575,0.009150055,0.05660415,-0.052508682,0.02875291,0.011206962,0.12748888,0.02939051,-0.0030802425,-0.07269485,0.025852889,0.003002366,0.03526914,-0.0103034545,-0.004392303,-0.023457024,0.0069085076,0.008541133,-0.07145772,-0.059049252,-0.0356529,0.042272773,-0.014918966,-0.027485646,0.0010576353,-0.03573271,-0.06028574,-0.14531626,0.017599737,-0.024439856,-0.02589376,0.019314405,-0.026129562,-0.041113805,-0.067894705,-0.05026922,0.008593514,0.06732013,-2.9206852e-33,0.029731177,-0.07789723,0.057416223,-0.012943492,-0.07990469,0.047243107,-0.029967075,-0.10246094,-0.032799564,-0.009920533,0.05427731,-0.07755857,0.024297662,-0.046894167,-0.005320385,0.073835626,0.006455983,0.05915733,0.05528459,-0.01838415,-0.058888104,0.10703547,0.037497815,0.041309014,0.05790208,0.0066907494,-0.04282774,0.0074059796,0.010108592,0.06733374,-0.04000654,0.05064278,0.0066574845,-0.041206446,-0.055812545,0.0267153,-0.028745309,0.03412105,0.07492917,0.066560075,0.0046433187,-0.029612554,0.03724044,0.1244261,-0.002136628,0.06962532,-0.004659944,0.015064509,0.024176188,-0.015838211,0.0043210546,-0.024256758,-0.07263516,0.00212822,0.027594104,0.0022143426,0.012941897,0.015766831,0.008554441,0.01594034,-0.058806766,-0.02084184,0.017478192,-0.020989811,0.056349672,0.006586155,-0.051956322,0.029071655,0.11825226,-0.017810486,0.08251892,0.056178883,0.061240964,-0.004316327,0.010501385,-0.02562745,-0.016341588,0.07465755,-0.019609774,-0.003986671,-0.034974977,-0.028475849,0.030566696,-0.023448572,-0.05588228,-0.14572279,0.12035535,0.0033307662,-0.12000239,0.0015676252,-0.07748492,-0.014673066,-0.0337215,0.050836507,0.013426445,-3.058459e-08,-0.0038239278,-0.01907344,0.020609407,-0.12761827,-0.002848576,0.002100884,0.02264046,-0.025455514,0.011521749,0.02993363,-0.08848133,0.084834546,0.0340354,0.019890368,0.058081552,-0.0020897058,0.008308869,0.037682824,-0.011960469,-0.013434107,-0.048341654,-0.029482437,-0.10189837,0.017704966,-0.008879358,-0.051282696,0.008588507,-0.05586724,0.040368777,0.04887909,-0.019791124,0.05486133,-0.022628222,-0.065195285,-0.10900917,0.020716099,-0.052931767,-0.080264635,-0.040265694,-0.004678562,-0.001657155,0.00638067,-0.056944657,-0.034197047,-0.07943083,-0.03490041,0.003890678,0.06853229,-0.043086585,-0.002308467,0.0415645,-0.023581062,0.03451802,-0.002575816,-0.05791948,0.064070426,0.11599506,-0.025395058,0.011544483,-0.015168608,0.009099642,0.014074882,0.15558586,-0.12798794 +1.14.14.184,"The enzyme, characterized from the mold Aspergillus fumigatus, catalyses a complex transformation comprising hydroxylation, bicyclic ring-opening, and two epoxidations, generating the sesquiterpenoid core skeleton of fumagillin.",384,1.0,-0.0080701355,0.05972768,-0.09205016,0.0077283666,0.014894301,-0.016776942,-0.106083915,0.057641033,0.05014926,-0.07046187,0.034460157,-0.08429946,-0.013161137,-0.022845821,-0.08580931,-0.021499392,-0.023338139,0.09054106,0.015043454,-0.0038183893,0.0677139,0.033680156,-0.037802733,0.023668824,0.04329543,0.0012755763,-0.0037395034,-0.003738563,-0.03612438,-0.12751098,-0.043071814,0.015793571,0.04587922,-0.021845194,0.06890557,0.079891026,-0.03463192,0.013507715,0.08602549,-0.03631514,0.02042051,-0.05585573,0.035185833,-0.091560416,-0.060304604,-0.013414759,0.009906125,0.01361735,0.0019405007,0.03566005,-0.030839184,-0.03674821,-0.06595669,0.0102996,0.06487654,0.028916802,0.022667404,-0.092167534,-0.07304267,0.033108503,0.067847215,0.004402356,-0.034557547,0.031868845,-0.01050342,-0.053072188,0.016303541,-0.05882409,-0.06204862,-0.04566696,-0.041147295,-0.05574139,0.0040136287,-0.030082973,0.06640412,0.048420653,-0.002916627,-0.025933318,0.06694679,0.0141022755,0.07534284,0.053383358,0.053230014,0.056375,0.04914341,0.05088387,0.00077639066,-0.01267246,0.011464392,0.07740521,0.04326563,-0.012620232,0.010586984,-0.045125145,0.001676123,0.06130039,0.047252182,0.08164578,0.05684762,0.0035486908,0.0073855636,0.015183733,0.025394488,-0.1383039,0.025808048,-0.00631543,-0.012300851,0.059052665,0.061248314,-0.067045815,-0.0052163275,-0.0648311,0.044897832,-0.077741764,0.022503803,0.027151713,0.021494497,0.020208325,0.02074848,0.044899978,0.05551921,0.037741926,-0.02767609,0.016904913,-0.04954878,0.0062904824,-0.04247697,2.2275409e-33,0.025957398,0.09460521,-0.029940156,0.046271857,-0.010489987,-0.059474334,-0.013718543,-0.009384444,-0.085829884,-0.0028259275,-0.10765644,-0.0011450192,-0.051167775,0.08304079,-0.022426441,-0.05290467,-0.010595243,-0.0014698209,0.04459124,-0.04757576,0.075154565,-0.0052631693,-0.078331634,-0.026087146,0.02629397,0.04398581,-0.01635846,0.015325539,0.009470467,-0.02479882,0.016151322,-0.017345125,-0.112998314,-0.00698298,0.06820878,0.012942548,0.06956271,-0.026977668,-0.098429084,-0.0040022214,-0.004742333,0.02152858,-0.084481105,-0.075238585,0.07290291,0.0012284176,-0.01820505,0.11205919,0.09220473,0.002799958,0.06008047,-0.0058545084,0.092730135,0.032868326,-0.035546366,0.0229431,-0.020626392,-0.041512348,-0.005227299,0.08920097,-0.024143118,-0.028186038,-0.059769057,-0.0035765297,0.041925717,0.035689447,-0.04673437,-0.053707097,0.03803396,0.02723076,-0.06527869,0.008639984,-0.03079857,-0.012629317,0.005173296,-0.021571917,-0.09043474,-0.046643436,-0.011743757,0.030898508,-0.0059702946,0.05650442,0.0118788,-0.08822297,-0.062113166,-0.030527305,-0.015058666,0.007167248,0.0042393864,0.04625923,-0.033650674,-0.097765915,-0.02539633,0.034519665,0.033332005,-3.8606754e-33,0.027178517,-0.15469514,0.039792363,-0.020400723,-0.0755222,0.03432415,0.026951145,-0.013189364,-0.034524553,0.009448955,0.035224788,-0.004626956,0.061965,-0.009948681,-0.020341305,-0.023333976,0.0033797405,0.036815614,0.018934833,-0.003475488,0.00015550703,0.090959646,0.0038270256,0.066038005,0.036676116,0.025942085,-0.029624473,0.012529705,0.02233182,0.116580576,-0.039926585,-0.025197113,0.033022005,0.07870487,-0.10778558,0.14175755,-0.08045377,0.012995961,0.040382992,0.049655434,-0.03749914,0.006259266,-0.018114263,0.07272802,0.09132524,0.04412361,-0.08518262,0.08063784,0.041714855,-0.06374191,0.036816157,0.054344025,-0.033382274,-0.04565497,-0.012894911,0.0124920625,-0.005126127,-0.11329982,0.021504175,-0.044665985,-0.056608897,-0.06701178,-0.012346919,-0.0068169236,0.06484605,0.03293089,-0.02210845,-0.08585657,0.013847061,-0.025377287,0.059085295,0.013830421,-0.025727132,0.016643291,0.0682363,-0.081945024,0.0028161108,0.014741719,-0.04824753,0.008912788,-0.03102157,-0.058873758,0.05496155,-0.056713294,-0.014696243,-0.104868904,0.07553204,0.060965747,-0.040836904,0.019291226,-0.03781342,0.0692328,-0.033588547,0.07345973,0.10369896,-3.324446e-08,0.056820378,-0.00886445,0.058112618,-0.05090398,-0.023223136,0.03969403,0.042637262,-0.04802261,0.05596329,-0.022547558,-0.08573173,0.10255761,-0.007481423,0.032611094,0.084337264,-0.0075944113,0.005553708,0.05096522,-0.0006101052,-0.0230802,-0.005808762,0.015411387,-0.10572856,0.007038326,0.006130287,-0.06968136,-0.03985384,-0.023124365,0.031370215,0.08017068,0.0076225065,0.06793417,0.005185764,-0.02589116,-0.09528725,0.010691122,-0.029379152,-0.054591928,-0.03275935,0.012829907,0.044876285,-0.035466842,-0.089666,-0.06676066,-0.0996136,0.001704505,0.025313413,0.041622702,-0.020981153,0.05119806,0.0679838,-0.025763841,-0.02877943,-0.02598948,-0.05768715,-0.0022601467,0.07205058,0.0066385944,-0.001835732,-0.04881898,-0.019587114,0.0246801,0.18560351,-0.06709985 +1.21.98.5,"This archaeal enzyme catalyses a C-C bond formation during the biosynthesis of tetraether lipids. The bond is formed between the termini of two lipid tails from two glycerophospholipids to generate the macrocycle glycerol dibiphytanyl glycerol tetraether (GDGT). The enzyme does not distinguish whether the two lipids are connected in antiparallel or parallel geometry, resulting in formation of two forms of the product, which are known as caldarchaeol and isocaldarchaeol, respectively. The enzyme can also form macrocyclic archaeol phospholipids by joining the two lipid tails of a single substrate molecule. Even though the reaction shown here describes phospholipid substrates, the enzyme can also act on glycolipids or lipids that contains mixed types of polar head groups. The enzyme is a radical SAM enzyme that contains 3 [4Fe-4S] clusters and one mononuclear rubredoxin-like iron ion, each found in a separate domain. The enzyme uses the 5'-deoxyadenosyl radical to initiate the reaction, which involves the formation of an intermediate bond between the substrate carbon and a sulfur of one of the [4Fe-4S] clusters. Two radicals are needed per C-C bond formed. The source of the required additional electrons is not known.",384,1.0,-0.102026485,-0.07717599,-0.12660018,0.009887554,0.014708093,-0.049530655,-0.08070683,0.010658709,0.0815031,-0.014863251,0.0011181417,-0.05759427,-0.049647126,0.029999025,0.008798833,-0.021648359,-0.10589055,-0.0030526088,-0.006227976,0.032511808,0.11478582,0.033400897,-0.04375731,0.037666604,-0.053215273,0.008855434,0.05779625,-0.0698825,-0.018269444,0.019059015,0.07087931,-0.08363667,0.044033717,-0.036426842,-0.012373907,0.10186971,-0.0664926,0.055490095,-0.01841039,0.012301285,-0.0018380887,-0.04176855,-0.0075327437,-0.05016945,-0.021915706,-0.02768408,-0.008917986,0.03576987,0.021902036,0.0111430995,-0.046815977,-0.06808235,-0.08649108,0.035540022,-0.034191657,0.07213617,-0.060374644,-0.012415286,0.025025902,-0.017361328,0.08418628,0.020011878,0.009876118,0.014405717,-0.0666314,-0.034390833,0.02009424,-0.08350019,0.061993975,-0.036839012,-0.044527218,-0.018639363,-0.05462297,0.0031582096,-0.03753145,0.069975324,0.04737405,-0.0012504631,0.06835763,-0.067027055,0.030395176,-0.032279987,-0.016670434,0.08578393,0.024184793,0.036903616,0.031691555,0.03342595,0.048096064,0.020298729,0.06993533,0.055949397,0.010813295,-0.063760504,-0.0029425297,-0.021948846,0.015829297,0.026217125,-0.015108806,-0.03980796,-0.008345682,0.03755947,-0.03533796,-0.102480486,-0.046766005,0.026603099,-0.028177582,0.055233072,0.03424492,0.04007545,0.010451236,0.01470092,0.11529841,-0.0012959728,-0.027706528,0.12222136,-0.026787918,-0.035150927,0.0076923827,0.02521454,0.0020556194,-0.016249564,0.05078784,0.01776445,-0.014625492,0.11207923,-0.07343096,5.7363452e-33,0.04387853,0.059414208,-0.021124598,-0.046783965,0.020041225,-0.020148512,-0.09588691,-0.007534416,-0.08706393,-0.0005318488,0.0005668619,-0.001541107,0.039276548,0.03882921,0.02217348,-0.0013444403,0.008871561,0.044932015,0.06726843,0.010666134,-0.0410144,0.09253896,-0.012204208,-0.049717918,0.040791065,0.07427739,-0.026532218,-0.028730495,0.00090506335,0.016863817,-0.0019258325,-0.12425055,-0.15354654,0.004637538,0.14924146,0.013669979,-0.02177907,-0.029778803,-0.05669218,0.0191359,-0.0009384566,-0.0355037,0.005730099,0.010586163,0.0422812,-0.016347582,-0.095808536,0.07552514,0.0730788,0.025927396,0.03655358,0.056618795,0.08082656,0.050679915,-0.09184699,0.024393855,-0.038376752,0.0038780223,0.017166361,0.03919328,-0.0014106997,0.09264588,-0.02917424,0.032971423,0.012457871,0.014147911,-0.07233506,0.0059586805,-0.006904182,0.06467605,0.06916023,0.02018009,0.088689275,0.052675597,-0.012605956,-0.030874526,0.03801208,0.0024851598,0.009344959,-0.016298065,-0.056443226,0.00086632447,0.04187495,-0.03651482,-0.062915824,0.033186357,-0.037582684,-0.052219477,-0.039301656,0.030307809,-0.05247261,-0.07275957,-0.05371859,0.0459874,-0.07769456,-6.9397e-33,0.017641215,-0.095446594,0.030851899,-0.103413776,-0.077807695,0.055030387,0.011318751,-0.049657647,0.01244068,-0.08093727,0.061464243,0.011963508,0.028049843,0.00020027345,-0.000544492,0.024180615,0.03606987,0.031179441,0.023485104,-0.04933053,0.08192541,0.053688023,-0.042694703,0.10852377,0.047774103,-0.04586636,0.0064882142,0.06457399,-0.0065756296,0.075805396,0.07992125,0.03306552,-0.045662172,-0.05848476,-0.08672632,0.03758781,-0.06253663,-0.03922143,0.07280953,0.020533105,0.00208328,-0.00085182674,0.048701677,0.013227791,0.03952507,0.037766743,-0.053846225,0.03627446,-0.020026322,-0.042814974,-0.008029198,0.0064568035,0.0024416256,0.080413684,0.018774582,0.06450109,0.017812908,0.09087801,-0.019459212,-0.06000451,-0.009066165,-0.09918005,0.062332757,-0.04746527,0.08828125,0.04287746,0.037830666,-0.016084889,0.008175646,-0.015505172,0.025975708,0.012633086,-0.013509812,0.05751992,0.033786096,0.054638196,0.040161904,-0.103719875,-0.007115911,-0.060479727,0.039073765,0.034645014,0.07770669,-0.087123364,-0.009683009,-0.06968192,0.045938894,0.11165306,0.0035716614,0.034595665,-0.03276193,-0.029307453,-0.04422327,0.0011202509,0.10154091,-4.728939e-08,0.04801262,-0.026596878,-0.010551036,-0.106019415,-0.08294061,0.019537536,0.0333794,-0.041005407,-0.048458453,-0.11601002,-0.048909303,0.052482508,-0.011789589,0.043556515,0.014210284,0.06960716,-0.067077465,-0.00012372393,-0.005689001,-0.08473417,-0.03989177,-0.029934749,-0.06959399,0.013807417,-0.064900056,-0.0557607,0.022854052,0.018601011,-0.0409942,0.014851791,-0.022253066,0.04289179,-0.050449938,0.008625787,-0.0007339952,0.02082993,-0.10742218,0.00652802,-0.049466707,0.07315845,-0.03439397,-0.006856403,-0.040972076,0.0135766845,0.011402541,-0.005176816,-0.022988405,0.046976693,-0.005446435,0.06464276,0.020479344,0.020901991,0.044748,-0.08276196,-0.11176497,-0.037407354,-0.054290086,-0.02927925,-0.013503857,-0.011784953,0.021311898,-0.0052738483,0.137858,-0.05312513 +2.1.1.386,"The enzyme adds a 2'-O-methyl group to the ribose of the last nucleotide in several types of small RNAs (sRNAs), protecting the 3'-end of sRNAs from uridylation activity and subsequent degradation.",384,1.0,0.03244543,-0.017157935,-0.052608583,0.008173432,0.04250942,0.06556864,-0.08878216,0.034198966,0.041733306,0.025221571,-0.0011388758,0.08485048,-0.07558779,0.019552419,-0.042968504,0.09853008,-0.1238579,0.014516455,-0.019594664,-0.06202734,0.12261494,0.09387673,-0.006503525,-0.021021148,-0.02397263,-0.03853454,0.06425518,-0.024569295,0.023302576,-0.0256929,-0.00908315,-0.08404645,0.06281901,-0.059127644,0.027089203,0.08609293,-0.02149544,-0.03046364,-0.004498582,0.0754198,0.030001722,0.015779886,-0.026345666,-0.017942142,-0.083890855,-0.034954883,0.022682989,-0.017099114,0.017467324,0.012395206,0.008896821,-0.037171293,-0.08087817,-0.0023800544,0.05882402,0.03238821,-0.06764786,-0.05394749,-0.04084048,-0.019364333,0.034932014,-0.045925695,0.007025985,-0.059950355,0.0956858,-0.04490276,0.047681347,0.00013987672,0.02427175,-0.02875182,-0.026342735,-0.002716369,-0.08146878,0.057146624,-0.04679387,-0.07035611,0.02314894,-0.050345007,0.060651332,-0.046499718,-0.03319473,-0.066092335,0.03340656,0.028303558,-0.005322065,0.10650309,0.058405202,0.038046762,-0.009022532,0.010171347,0.036676094,0.012369183,0.013283375,-0.028188974,0.03238049,-0.009959645,0.013272067,0.011237704,-0.02273322,-0.04540429,0.08769452,0.05625069,-0.016386705,-0.07396066,0.0053432537,0.020758308,0.007360465,0.065444276,-0.044643298,0.101142675,0.011626106,0.062968746,0.006011299,-0.017412296,-0.08626911,0.044714075,-0.004318171,-0.025911178,-0.03272447,-0.031395126,-0.0045806007,0.04123476,0.011465387,0.04033487,-0.0007474888,0.04022822,-0.061888512,-5.3235857e-34,0.04780401,-0.009864592,-0.045045853,-0.024569115,0.008153093,0.030380134,-0.056931086,0.00818476,-0.060962487,-0.016496245,-0.07366717,-0.094507284,0.019297635,-0.065386534,-0.02062161,-0.015913025,-0.02538096,0.025452953,-0.008205264,-0.042090178,-0.010573378,0.085466824,0.05258092,-0.010965283,0.016615665,-0.025293605,0.056860894,-0.029211432,0.000104257786,-0.033114374,0.018332463,-0.033432443,-0.113464974,-0.014529267,0.107439645,0.006585112,-0.020423342,-0.0342108,-0.015283494,0.08340339,-0.012621171,0.055566043,0.00940376,-0.041779555,0.06737035,-0.08086321,-0.020848846,0.072372824,-0.042574126,0.08159968,0.03554934,-0.05295792,0.06341442,-0.027287507,-0.049156237,-0.094866164,-0.0380953,-0.08440708,-0.001918037,0.009695967,-0.026968626,-0.013365809,0.0067010843,0.09125564,0.025007423,-0.005112467,-0.058149975,-0.06990461,0.058517188,0.049534205,-0.00896895,-0.061737347,0.10417985,-0.026746139,-0.08172082,-0.024369955,-0.057841398,0.0028587256,0.037152454,0.05471152,-0.00922142,-0.051064245,-0.042382095,-0.035021827,-0.048347324,0.011247335,0.01843097,-0.14585899,0.012431886,0.012087781,0.051606618,-0.066398956,-0.07914942,0.03221224,0.019097807,-1.0198719e-33,0.057510324,-0.07770883,0.09850418,-0.04980196,-0.04750204,0.016586317,0.07353684,-0.049436875,-0.03859408,-0.033339307,0.06433,0.09016827,0.057369858,-0.093240306,0.054480325,-0.01404864,0.040369563,0.014644707,0.019809434,-0.019582575,0.055567805,0.09588949,-0.016984282,0.0812519,0.039122038,-0.047833707,0.008443722,-0.0037532202,0.01952165,-0.03408645,0.036319457,-0.033319097,-0.022432193,0.0033553464,0.002999528,0.018393964,-0.011431811,0.08418561,0.02756924,0.010566726,-0.036318015,0.050466314,-0.044569056,0.09659082,-0.0136967795,0.050445113,-0.071102604,0.012911798,-0.027085483,-0.098596156,0.025927344,-0.10546195,0.058342922,0.014847302,0.063803546,-0.046374235,-0.047764104,0.036990814,-0.009932116,0.03342443,-0.024897737,-0.026203811,0.02538051,-0.011337671,-0.009752673,0.018981298,-0.015535774,-0.023436079,-0.018129619,-0.033552684,0.06387724,-0.020728353,0.032913733,0.007107736,-0.047174055,-0.0685222,-0.1051201,-0.039972488,-0.059438836,-0.0145373205,-0.03808772,-0.022435062,0.008203076,-0.017972274,0.06518571,-0.06489141,0.060036365,0.12330854,-0.02502254,0.068196304,-0.045270786,0.044972695,-0.028390583,0.060046762,0.04263372,-3.1186865e-08,-0.015983159,-0.015649557,0.0033156283,-0.029859172,0.002621654,0.023184631,-0.008459245,0.066061854,0.07096562,0.08908242,-0.0017700809,0.054323353,-0.014806675,-0.01471118,0.090279065,0.044612803,-0.07384668,-0.0357229,0.003784037,-0.021463415,-0.09069018,0.012590047,-0.122196674,0.045849413,-0.040393263,-0.0032870835,0.046573292,0.056726683,-0.0046991683,-0.037191775,0.1298744,0.03817257,0.11192621,-0.00012313917,-0.09618273,0.08302194,0.12636518,0.07073756,0.011350137,0.039216228,0.00023131375,-0.06425211,0.0012877891,-0.006219511,-0.07504429,-0.00981617,-0.040029243,0.064630575,-0.059967354,0.022243658,0.11401063,-0.020735411,-0.04803829,-0.012123408,-0.025449397,-0.021889364,-0.024680845,-0.049652256,0.03956077,0.046331674,0.06817316,0.005867691,0.1377843,-0.058248598 +2.1.1.387," The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin.",384,0.99999994,-0.013194714,0.08426623,-0.15314691,0.0042583155,0.07669596,0.03556399,-0.12359502,0.07957563,0.07033358,-0.07844282,0.020286579,-0.07060971,-0.10150141,-0.007963656,-0.07340262,0.028289419,-0.040555183,0.064648956,-0.028512748,-0.053716686,0.101600006,0.05106454,-0.026595494,0.041529473,-0.006145743,-0.010954082,0.027407868,-0.023559542,-0.04815272,-0.056179382,-0.07455112,-0.038660422,0.071874835,0.0003855455,0.064187,0.10615383,-0.037358988,-0.035061527,0.069723144,-0.042720538,0.023476737,-0.07910763,-0.05791432,-0.031875964,-0.08408508,0.0085929725,0.009872482,0.062404007,0.030728752,0.049025647,-0.08893177,0.014458112,-0.004192725,-0.035360016,0.011298559,0.08031752,0.042603727,-0.0849133,-0.047438677,0.014181911,-0.009345995,0.014362042,0.009788982,-0.0021436845,-0.012857222,-0.05748513,-0.008065521,-0.050944522,-0.042621642,-0.05288711,-0.025129735,-0.037646722,0.04544057,-0.02848791,0.07198101,0.061894197,-0.010602163,-0.021630632,0.060060214,-0.00075984985,0.08746071,0.035053134,0.012662932,0.043981526,0.060426258,-0.05436344,0.014854284,0.016819231,0.051809166,0.07931996,0.018508863,-5.4095144e-05,-0.0026981663,-0.025029942,0.0056785084,0.0741202,0.05955696,0.03742544,0.031273216,-0.03264231,-0.005789022,0.006435523,0.012274485,-0.087937675,0.053314455,-0.015985856,-0.010633863,0.077307,0.061578937,-0.04259365,0.006449544,-0.055717565,0.07184141,-0.03588154,0.026697587,0.028487522,0.002905563,0.014431176,-0.042470478,0.036238264,0.04900379,0.03865447,0.053950977,0.0505779,-0.0020660344,0.040224425,-0.08501737,2.921367e-34,0.07899072,0.06118661,-0.05065336,0.021782603,0.019982843,-0.05368414,-0.020136911,0.0011796212,-0.056300323,-0.032745205,-0.096168436,-0.09118066,-0.082439974,0.03850966,-0.047844224,-0.025014315,0.028061908,-0.0062111667,-0.007261626,-0.010952813,0.024629543,0.024404326,-0.06785587,0.0161112,-0.016705807,0.07697225,-0.03367229,0.046467733,0.0022913876,-0.01585136,0.028222775,-0.06846569,-0.084395476,-0.025757568,0.10964587,0.029215872,-0.018532401,-0.034122422,-0.11031776,-0.014042738,-0.0011401016,0.03356952,-0.029594058,-0.08751778,0.02255427,-0.0074781086,-0.025816707,0.063695975,0.05016104,0.021416975,0.03406206,-0.015046354,0.11678528,0.0119791,0.011868517,-0.031523254,-0.025433455,0.010365353,0.0033627257,0.033687185,-0.06357239,0.023398232,-0.033468574,0.06341209,-0.00013626806,-0.007510969,-0.033089597,-0.022078227,0.011412262,0.033896275,-0.004312672,-0.017055033,-0.060024675,0.012016005,0.021078175,-0.026654081,-0.060500335,-0.025476018,0.0068230764,-0.022361929,-0.0104276035,0.041137278,-0.014559241,-0.08195347,-0.10942759,0.020204281,-0.0011303452,-0.045790046,-0.006901632,0.007936213,-0.049488604,-0.11450745,-0.035627153,0.035954222,0.06067996,-2.7169813e-33,0.011908876,-0.11799963,0.040389158,-0.012682059,-0.08597928,0.073317245,-0.031057633,-0.012339876,-0.057074744,-0.026997622,0.011684597,-0.068767175,0.046448827,-0.016640985,-0.01981951,0.047287215,0.07018786,0.049890723,0.02861646,0.0010323155,-0.038200855,0.1108314,0.039108455,0.020786578,0.068748154,0.004106989,6.112532e-05,0.029025234,0.011134886,0.043600272,-0.038738776,0.08694697,0.0024286243,0.024181359,-0.069179155,0.05318679,-0.055541992,0.017154392,0.088298924,0.04570783,0.005057733,0.0030629986,0.027955752,0.08514548,0.0112698395,0.09200643,-0.015938403,0.016183121,0.01647599,-0.038993176,0.0031284837,0.023495669,-0.014775316,0.014077647,0.0013078195,0.013621817,0.0075542117,-0.040901996,0.007206568,-0.024626931,-0.06295023,-0.06513362,0.0022957735,-0.020437043,0.054072555,0.027987653,-0.053097542,-0.0042795837,0.11631746,-0.033395804,0.124982975,0.049853094,0.015860587,0.076293685,-0.0077193924,-0.057251547,-0.037542976,0.018616807,-0.014846743,-0.0123153385,-0.028940152,-0.013785874,0.0586092,-0.042583,-0.07973923,-0.12238668,0.13717242,0.06517082,-0.09125479,0.046054292,-0.051585976,0.025974264,-0.07514338,0.07702949,0.049616285,-2.7798583e-08,0.025292229,-0.02057209,0.052370735,-0.09667305,-0.0063217236,0.008979885,0.024694826,0.0140941255,0.028320601,0.007551902,-0.10673791,0.049614727,0.00364408,0.022580035,0.040623132,-0.011087783,-0.021070292,0.04272365,0.012201054,0.02062667,-0.022364201,0.0012351085,-0.11948355,0.031705163,0.0008248227,-0.063073196,0.018797267,-0.024258059,0.024961477,0.032289293,-0.027000131,0.06705008,-0.0070264027,-0.060738467,-0.08489591,0.048794392,-0.047907818,-0.1026034,-0.028465552,0.008949056,0.042177543,-0.0133862,-0.049768195,-0.038066506,-0.10661356,-0.027015176,0.0403356,0.05989684,-0.04492113,0.009675358,0.037848834,-0.019372405,0.00974855,-0.030477524,-0.08614668,-0.014526125,0.10744375,-0.016589653,-0.018667527,-0.015238376,-0.015732385,0.009561209,0.19888431,-0.08359069 +2.3.1.311,"The enzyme, found in eukaryotes, most archaea, and some bacteria, catalyses the first step in modification of the wobble uridine base of certain tRNAs. In eukaryotes the enzyme is a complex of six conserved subunits, with ELP3 being the catalytic subunit. In archaea and bacteria the enzyme consists of a single subunit, homologous to ELP3. The enzyme contains an [4Fe-4S] cluster and uses radical chemistry. A 5'-deoxyadenosyl radical generated in the radical AdoMet (SAM) domain attacks the acetyl-CoA donor, activating its methyl group, which forms a C-C bond with C5 of the uridine moiety.",384,0.99999994,-0.043479696,-0.086497515,-0.09652241,0.006019545,0.10283619,-0.053072274,-0.08947755,-0.016159525,0.065715164,-0.0082714865,0.022713173,-0.021308145,-0.08542966,0.028851148,-0.01183097,0.058462385,-0.12437383,0.051793564,0.01868198,-0.047770973,0.05936,0.01893092,-0.024821619,-0.028352574,0.020661693,0.0268432,0.12255669,-0.03505602,-0.07351272,-0.101736754,0.026154192,-0.038420673,0.05849724,-0.054205935,-0.00010420175,0.0904131,-0.060063247,-0.064286925,0.06120532,0.0027273207,0.026378397,-0.006280458,0.051467285,-0.060905233,-0.053443223,-0.02119924,0.015514691,0.015407124,0.04057341,-0.00025263632,-0.026891487,-0.011072456,-0.03536797,0.0446982,-0.04336241,0.002180442,0.0066625825,-0.041433394,0.05478626,-0.010479713,0.123864785,0.026472421,0.03519765,-0.055198003,-0.020308223,-0.05501244,0.064630024,-0.07258912,0.04806555,-0.015076935,-0.07151514,-0.028435962,-0.026997847,0.056964513,-0.020235002,0.04045772,0.014258071,-0.05949452,0.07138411,0.03550784,0.019329727,0.0122573245,0.033788033,0.06356913,0.08141388,-0.014957662,0.015184212,-0.007887824,0.045539986,0.0022593099,0.030463234,0.011089948,-0.014358936,-0.05250056,-0.06265978,0.035952665,0.023204561,0.028206771,-0.056406707,-0.01641549,-0.024411859,0.0950615,0.020432357,-0.093256116,-0.025956826,-0.038474675,0.0062840236,0.17480902,0.01392306,-0.006664109,0.0001304644,-0.006681378,0.09653888,-0.0022092306,0.0013239539,0.05514258,-0.003491328,-0.080206655,-0.0530056,0.05284016,0.022853032,-0.006189056,0.061987508,0.024082378,-0.032684267,0.022711314,-0.15123731,1.5630497e-33,0.090979755,0.08434772,-0.024636073,0.004090813,0.00088884716,-0.042490657,-0.059821248,0.009849566,-0.029767806,-0.047611687,-0.08541693,-0.09112205,0.14043848,-0.010725189,-0.07967218,-0.034937777,-0.062882565,-0.013386393,0.041983787,0.013475938,-0.039983083,0.060756408,-0.06174169,-0.0027651615,0.02193403,0.02303835,0.012656723,-0.01987642,0.03323623,0.042178027,0.011372167,-0.02569647,-0.1663345,-0.009478129,0.11729592,0.017256988,0.009859728,-0.05586338,-0.065121315,0.002466863,0.001411495,0.031733867,0.0017114694,0.013470845,0.05502728,-0.016862532,-0.03702123,0.094369054,0.0027400337,0.0701692,0.03452516,-0.024310308,0.1181288,-0.0007067441,-0.08352761,-0.039426304,-0.06948654,-0.037093684,0.054594543,0.05570368,0.025508853,0.03358149,-0.031621803,0.06824434,-0.037445255,0.04903132,-0.00911165,-0.06987499,0.030121047,0.048461266,-0.008924058,-0.02576813,0.08903803,0.044102337,-0.0633157,-0.042296223,-0.011826824,0.022925686,0.06448613,0.016542245,-0.06348602,-0.08564681,0.039164405,-0.013472049,0.012101123,-0.024701022,-0.03560064,-0.008022484,-0.012507317,-0.014395615,0.039553665,-0.05266271,-0.04979084,0.03718269,-0.018747855,-1.9057023e-33,0.08867698,-0.13810666,0.008766965,-0.07540363,-0.09342474,0.07228921,-0.017084794,-0.027295953,-0.034126345,-0.06752958,0.13978869,-0.019732902,0.01683256,-0.08629868,0.092525,-0.060839023,0.04440666,-0.030583838,0.0021429863,0.025838483,0.078928195,0.007796487,-0.031394303,0.02289549,0.05036244,0.038683895,0.009347827,-0.020216426,0.075629234,0.017509215,0.022793164,0.0126736695,-0.04848039,0.007788111,-0.03866197,0.090887815,-0.03170097,0.010463937,0.036796104,-0.016811064,0.04033592,0.0005591715,-0.0027706232,0.094372034,0.03252226,0.036874026,-0.008290676,0.03729354,0.0036981723,-0.09262276,0.051255587,-0.06146455,0.024466306,-0.045934808,0.010017837,0.060948845,0.030157842,0.007097916,-0.062171318,0.008964798,-0.06636667,-0.012402736,0.084036395,0.013995073,-0.0012069743,0.025888994,-0.03615268,0.058213804,-0.015802147,-0.07495981,-0.011435391,-0.006842698,0.047528405,0.05380462,0.007301197,-0.0634518,-0.03857481,0.0024143907,-0.0047757933,-0.031330843,0.0018381673,-0.045886148,0.013291408,-0.08108567,-0.0012029749,-0.072191834,0.041394453,0.11607709,0.022163987,0.025939705,-0.034801394,-0.00016262455,-0.061389174,0.048763532,0.10573229,-4.166803e-08,0.007810009,0.0029609557,0.056261864,-0.04857879,-0.011340465,0.10437273,0.026999656,0.0508294,0.009880266,0.00031412387,0.037020504,0.09186931,-0.020458609,0.03584219,0.02284757,0.01617846,-0.048568573,0.025055107,-0.011629569,-0.013415693,-0.038164843,-0.02257277,-0.055636548,0.013154474,0.03702999,-0.032788593,0.023789097,0.0031126863,-0.045715127,-0.049214,-0.0038070204,0.00927811,-0.013077303,0.034530167,-0.099933736,0.03415812,-0.011236098,-0.07594397,-0.057693563,0.07915415,-0.0436842,0.0019252639,-0.11894455,-0.020347504,-0.018602345,0.026308492,-0.017723806,0.035151776,-0.062959,-0.0026314077,0.017500108,-0.019175313,0.002736554,-0.02396444,-0.05434109,0.015119062,-0.0341834,-0.085669324,0.045095857,0.03421695,0.041517295,0.033213135,0.080921724,0.0021235016 +2.4.1.390,"The enzyme, characterized from the bacterium Lactobacillus fermentum NCC 2970, possesses hydrolysis and transglycosylase activities on malto-oligosaccharides with a degree of polymerization of at least 6, as well as polymers such as amylose, potato starch, and amylopectin. The enzyme, which belongs to glycoside hydrolase 70 (GH70) family, attaches the glucosyl residues by alpha(1->3) linkages in both linear and branched orientations. While capable of forming large polymers, the enzyme produces mainly oligosaccharides in vitro.",384,0.99999994,-0.0076477677,-0.09103001,-0.06787212,0.029155679,-0.0020434575,0.014245842,-0.017063659,0.024403099,0.0042770035,-0.006354381,-0.0253885,0.04459932,-0.056892544,0.051526703,-0.07605305,-0.046671774,-0.017580522,0.014411722,0.0294727,-0.008181086,0.08608926,-0.0053194687,-0.03641665,0.013300276,0.068850145,-0.058332108,0.068990305,-0.053021535,-0.04605225,-0.04986882,-0.027856797,-0.07889978,0.020549227,0.04816884,0.012509031,0.0571046,-0.0063164504,-0.053440332,0.00014811315,-0.047879,0.062405296,-0.052213345,0.07277202,-0.051981654,-0.115870394,-0.03751727,-0.025767948,-0.026072325,0.022796782,-0.0028543137,-0.08438491,-0.08578102,-0.06842487,0.010863625,0.06857424,0.018368686,0.007519952,-0.086161174,-0.009945744,0.070189476,0.035155185,0.062217213,0.024015462,0.020679832,-0.0793317,-0.0887946,0.05753045,-0.029792076,-0.06925804,-0.017277572,-0.08370783,-0.013527734,0.012332669,0.010177464,0.07436724,-0.000820295,-0.02691187,-0.00033540474,0.040162425,0.0031305456,0.04579096,-0.025569208,0.032210328,0.105188616,-0.052598543,-0.024796102,0.077903725,0.036659066,0.062412094,0.010784558,0.011229839,0.02998004,-0.022136379,-0.09405804,-0.008954076,-0.012693973,-0.01063592,-0.074559756,0.036244337,-0.06194882,-0.04704596,0.009839072,0.10484516,-0.05798407,-0.07882321,0.05750716,0.01205784,0.086798996,0.10417222,0.03859255,-0.018159704,0.061692342,0.062176846,-0.02559733,-0.08297243,0.011003625,0.046023544,-0.07808209,-0.04391843,0.0036185957,0.033743408,-0.016988808,0.13280137,0.01455459,-0.060709186,0.06203076,0.019035265,1.51420965e-33,0.08715451,-0.017947463,0.04095341,-0.052860495,0.004559027,0.007449034,-0.02996629,0.0016128788,-0.037650056,-0.05866585,-0.060166776,-0.0740348,-0.0036783873,0.1270768,0.040779617,0.05770768,0.02176156,0.001441189,0.032352038,0.049365148,-0.005331314,0.06757838,-0.0047876937,0.054896526,0.07018351,0.06376884,-0.052379537,0.04667933,0.009062909,-0.016528074,0.07903184,-0.0054492853,-0.09060419,0.041905943,0.09338957,0.07504699,-0.07249434,-0.014077459,0.045351602,0.038385402,0.042169053,0.022418354,0.05876921,-0.08787593,-0.0006379584,0.0527783,-0.001962015,0.08133481,-0.0039064516,0.09006605,0.053574964,0.031500574,-0.065495335,0.051901877,0.002609041,0.07668759,-0.018014394,0.0282595,0.049071483,0.005489831,-0.0023835967,0.04320432,0.013785656,-0.051384564,0.017441915,0.0073104785,-0.025218768,0.028455758,-0.03136244,0.034530777,-0.052748777,-0.07246496,0.01589677,-0.0028838818,-0.037977055,-0.04814213,-0.029304363,-0.04820013,0.037926264,-0.041325297,0.014959634,-0.016914846,0.00658835,-0.076649815,-0.052932605,-0.011710646,-0.073235914,0.009476493,-0.0524318,0.010689662,-0.031453077,-0.036505442,-0.04408686,0.06847889,-0.05398316,-4.605533e-33,0.13372798,-0.12482919,0.06739891,-0.007915272,-0.04846623,-0.041960448,0.05277624,0.013039433,-0.058440447,-0.063212626,0.057416562,0.0033527827,0.052421436,-0.02687868,0.007151862,0.007317893,-0.07157853,0.101576634,-0.021644764,-0.007498056,-0.030324822,0.107175216,0.032911737,-0.0031269519,0.08681883,-0.03708833,-0.025662856,0.06926031,-0.021888124,-0.004107044,0.014316143,-0.027637865,-0.041064512,-0.060684077,-0.08151269,0.0345358,-0.08387418,-0.054761473,0.11587934,-0.022329139,0.0376297,0.036290497,0.00757319,-0.010074811,0.028326048,0.007908226,-0.06371875,-0.012436718,0.022898866,-0.044405993,-0.015961,0.02863253,0.027784217,-0.007940032,-0.011961647,0.09307149,0.031518344,0.005965635,0.014306285,-0.07243829,-0.045275345,0.022336576,0.078047186,-0.018601924,0.021366948,0.038699526,-0.020953069,0.0036742764,0.020063527,-0.057580296,-0.017216774,-0.01064431,0.005357198,0.08176805,0.015150975,-0.045949027,-0.108148,0.0068639033,-0.060275607,-0.001490758,0.04430225,0.03359376,0.01189369,-0.031576846,0.017952515,-0.045249574,0.056422114,0.071021095,0.0231842,0.02465439,-0.0455579,-0.005853585,0.010137403,0.04670043,0.08470023,-3.6355463e-08,-0.011949241,-0.071700975,0.0047922707,-0.08408812,-0.05930212,-0.0125615895,-0.033500955,-0.02477164,-0.03945852,-0.069663726,-0.004695558,0.1221041,-0.08784094,0.09135043,-0.022391137,0.0053165983,-0.070994586,-0.028398171,-0.02102401,0.023473684,-0.12829046,-0.03458139,-0.10480924,0.086445406,-0.048922107,-0.028531179,0.0036684808,0.07197303,-0.06615858,-0.038184788,-0.03683989,0.08325659,-0.015685499,-0.022995807,-0.021493696,0.009895073,-0.050294623,-0.011045773,0.029218597,0.0040079565,0.07902826,-0.02697653,0.00945397,-0.028478896,-0.009898791,0.013470772,-0.035508413,0.036366615,-0.055255797,0.07389448,0.016743818,0.015180327,-0.0647686,-0.02554181,0.013020419,-0.040689763,-0.011346392,-0.020883596,-0.012934787,-0.03896331,-0.00010469569,-0.042603925,0.18993914,-0.06819972 +2.4.1.391,"The enzyme, characterized from the bacterium Ignavibacterium album, transfers a glucosyl residue from the non-reducing end of a 1,2-beta-D-glucan to a glucose residue of an acceptor molecule, forming a beta(1,2) linkage. The donor molecule can be as small as sophorose (which contains two glucosyl residues). The enzyme has a very broad specificity for the acceptor, and can act on various aryl- and alkyl-glucosides. In addition, the accepting glucose unit can be in either alpha or beta configuration.",384,0.99999994,-0.03659884,-0.039270416,-0.12930219,0.051492345,0.05737913,0.003331345,0.03536641,0.03778838,0.051301125,-0.026784379,0.012592603,0.038667697,-0.0743296,0.046001483,-0.05619093,-0.022474978,-0.079651035,-0.028753102,-0.00013998015,0.005191145,0.079683356,0.019841237,0.007549081,-0.03813721,0.062208563,-0.038126845,0.0037092848,-0.031552363,-0.004859976,-0.08542965,0.008104951,-0.058143917,0.0068231067,-0.005473336,0.041902073,0.049052365,-0.020602006,-0.045027643,0.029721392,0.012994565,0.066102564,-0.024465203,0.006835532,0.057708062,-0.09224659,0.0011670209,-0.007836591,0.110284835,0.03434835,-0.025845224,-0.018809984,-0.070630156,-0.10535372,0.06811903,0.03359088,0.019561667,-0.04087757,-0.07490714,-0.016219962,0.001749091,0.0411613,0.028852185,-0.0385162,0.021264557,0.0061611896,-0.115016975,0.062241506,-0.12022007,-0.0031093657,-0.049037144,-0.031135311,-0.03748313,0.017276082,0.036623504,0.026482599,0.012576963,-0.044522893,0.08996061,0.06256154,0.030501168,0.043372177,-0.021736728,0.06962714,0.07287998,-0.020335522,-0.018644033,-0.017625619,0.0656839,0.04263199,0.019487264,0.01127678,-0.01080853,0.044340573,-0.09415381,-0.036490407,-0.021337131,0.069363855,-0.052778225,0.078953706,-0.0026140262,-0.030654538,0.0388717,0.0403615,-0.037374143,-0.07129659,0.017956078,-0.016532723,0.07588589,0.055191167,-0.032370325,-0.026515815,0.0027381827,0.086406395,0.006242303,-0.044421393,0.055810712,0.050788246,-0.071517885,-0.08103202,0.010962765,-0.019323286,-0.021028735,0.07718096,0.0056150816,-0.08232566,0.10512016,-0.1524382,-2.5589998e-34,0.052164827,0.061736453,-0.014729549,-0.04983686,-0.049173262,0.024594469,-0.0892177,-0.018808052,-0.042467155,0.04713883,-0.12754421,-0.052894734,0.053525615,0.12414033,0.015980683,0.048151333,0.0055362433,0.06970369,0.08931814,-0.029016739,-0.009515711,0.06650175,-0.006955471,0.003125672,0.092193395,0.082577154,-0.1014158,0.022710515,0.02543925,-0.019522592,0.083707824,-0.057248283,-0.09640291,0.040055245,0.043811698,0.0040427167,-0.058936067,-0.019256983,-0.0006912855,-0.030936122,0.033831697,0.036856003,-0.009410333,0.011954625,0.06838259,-0.01211252,0.0077842535,0.010638649,0.00634281,0.07223772,-0.0010371017,-0.0037976275,0.012608623,-0.021698179,-0.036710095,0.09463919,0.02609594,0.033144448,0.012616321,0.011995133,0.011809552,0.084755786,-0.0027904636,-0.026312761,0.005271009,0.012428966,-0.063025236,-0.06459792,-0.012674116,0.08089276,-0.08034467,-0.021977788,0.010165473,0.03809793,-0.013728553,-0.087392844,-0.059708167,-0.075872384,0.080929495,-0.046832297,-0.060098756,-0.067948096,-0.012056719,-0.053473193,-0.10973452,-0.047941208,-0.012359247,-0.059084065,-0.036269974,0.0070662596,-0.0018248026,-0.03564869,-0.08829035,0.017098116,0.07244174,-1.7796661e-33,0.099541515,-0.11066075,0.04940751,-0.035100255,0.019794237,0.0692139,0.054145347,-0.09171557,0.028510438,0.060576838,0.07824104,0.08208209,0.018319134,-0.030824598,0.02402342,-0.029717024,-0.033542234,0.048023265,-0.02645947,-0.031363375,-0.0008385942,0.0618972,0.044479832,-0.031570803,-0.0439738,-0.01212453,0.034161568,0.009298299,0.02983084,0.04547221,0.033164214,0.020960994,-0.03824244,-0.08368236,-0.0070025027,0.022635179,-0.009320562,-0.025766613,0.026921986,-0.00855557,0.052102014,0.056586348,0.004880518,0.052931894,0.0790949,0.030479709,0.005707467,-0.010746504,-0.0049376017,-0.077783585,-0.011437486,-0.025530038,0.006358424,0.0129856495,0.035080057,0.053007398,0.009372498,-0.022347854,-0.053746216,-0.02450354,-0.030188804,-0.10209231,0.05356483,0.0002112734,0.045776162,-0.026628437,0.048056792,0.022906858,0.03365206,0.030646391,0.006546975,-0.058244582,0.027259488,0.07849046,-0.01747056,-0.021191107,-0.052841537,-0.07151777,0.025270103,-0.09506092,-0.03854311,0.04581815,-0.0043533877,-0.036546603,0.067342505,-0.08722542,0.032957647,0.098926365,0.016668824,0.06345076,-0.030776504,0.06433945,0.025538163,0.021011773,0.08271487,-4.1343505e-08,0.011720792,-0.00687238,0.024442893,-0.02563965,-0.00069941964,0.051600404,-0.027545286,-0.008040454,0.022953693,-0.005282013,-0.03411924,0.13275918,-0.01906047,0.013666497,0.034359373,0.008069277,-0.05743146,-0.012817285,-0.060300674,-0.038652144,-0.08975312,0.015931236,-0.047984198,-0.0152464975,-0.0026648797,-0.100019395,0.023200551,0.066421695,-0.066235565,0.021397008,0.0049540987,0.062370855,-0.053465538,-0.032882914,-0.06917054,-0.007009028,-0.00031938835,-0.008770571,0.021350576,0.048431575,0.078172825,-0.015805356,-0.09924777,0.016786497,-0.019020062,0.06667227,-0.016401475,-0.0153206345,-0.09481433,0.042508166,0.0725769,-0.045187194,-0.08494125,-0.019848472,-0.098289676,0.017110469,-0.093175136,0.027623681,0.024526583,-0.033022482,0.031816706,0.0066941986,0.11597954,-0.04550988 +2.4.1.392,"The enzyme, characterized from the bacterium Paenibacillus borealis, catalyses a reversible reaction, transferring a glucosyl residue attached by a beta(1,3) linkage to a D-glucuronate residue (either free or as a part of a beta-D-glucuronide) to a free phosphate, generating alpha-D-glucopyranose 1-phosphate.",384,0.99999994,-0.14585209,-0.038749244,-0.041669607,-0.012551477,0.0069919224,-0.0049390923,-0.0022824777,0.01579076,0.07050975,0.052365646,0.0014889683,0.010390751,-0.04769496,0.037769046,-0.10081647,-0.046791263,-0.07334132,0.04427463,0.006944413,-0.019195842,0.08372741,0.054806143,-0.012573785,0.008032264,0.11966391,-0.0065153628,0.065792605,-0.06477894,0.011775997,-0.025795214,-0.026050583,-0.09755682,0.05541344,-0.024213592,0.055977967,0.10451975,-0.04461969,-0.033289146,0.05707074,0.028201085,0.059258293,-0.008695608,-0.014437993,0.016313458,-0.09956618,-0.0011917627,-0.06166556,0.09291279,-0.0037452402,-0.019004833,0.010068853,-0.1029485,-0.111481324,-0.036465105,0.02181559,-0.017334731,0.0068838964,0.0059979944,-0.024886113,0.020940075,0.07497995,-0.013934129,-0.020435564,0.02591273,0.026039654,-0.09346913,0.041348252,-0.0768281,-0.004732311,-0.0262606,-0.054920312,-0.012697577,0.009225336,-0.037574086,0.048543774,0.0032743828,-0.04562962,-0.0055112154,0.027379874,0.0056154723,0.08576589,-0.0058337026,0.026919814,0.09091139,0.0145292645,0.030699953,-0.036497116,0.024817744,0.09712136,-0.02263019,-0.007800573,-0.05496432,-0.019498888,-0.064917095,-0.018949771,0.018475471,-0.002897469,-0.007778677,0.0602412,-0.010612506,0.005326008,0.08677089,0.046155654,-0.0611193,-0.08520047,0.006358119,-0.036075998,0.06138334,0.016634012,0.025192881,-0.07117264,0.06374783,0.06544003,0.048214246,-0.10667255,0.041385237,0.025666384,-0.059826,-0.09057536,-0.012159822,0.030540714,-0.08168244,-0.0006546901,0.06056445,-0.0862572,0.054095857,-0.06924691,1.8128154e-33,0.06966957,0.07605277,0.021473546,-0.031895902,-0.022429684,-0.037846938,-0.099011645,-0.07742117,-0.11023019,0.032874063,-0.034238536,-0.029916083,0.016518828,0.080431506,-0.025870316,0.06722978,-0.016101519,0.107344456,0.097782135,-0.00034681975,0.056835823,0.039235353,-0.020681875,0.0196408,0.078678355,0.06001572,-0.080836296,0.07878772,0.02526822,-0.021208547,0.024325019,-0.074284054,-0.07355006,-0.0019234633,-0.020833656,-0.055044286,-0.09452531,-0.11422271,0.032084927,0.00935999,-0.0077881813,0.002867262,-0.010943688,-0.028662048,0.02862304,-0.010464599,0.01984362,0.063270226,-0.039020654,0.08421865,0.019048197,-0.0019108074,0.059792496,-0.0036538523,-0.048466608,0.03334507,0.008641969,-0.04818015,0.046148814,0.030982155,0.068832844,0.09077921,-0.015055449,-0.003292435,0.020707482,-0.04914906,-0.020070666,0.02268574,0.022357441,0.08464867,-0.008855942,-0.034329288,-0.047096845,0.034005858,-0.02994833,-0.075664625,0.011726979,-0.040391043,0.014104825,-0.03153091,-0.012501174,-0.03401268,-0.023931405,-0.046359673,-0.06854382,-0.014108968,-0.028520247,-0.07812714,-0.062589146,-0.00809638,-0.012581592,-0.051326208,-0.09651019,0.07218446,-0.00018553708,-3.4868127e-33,0.10565229,-0.1131544,0.052098498,-0.07679928,-0.04029249,-0.013429647,0.02477436,-0.05915693,0.043160915,-0.0101067815,-0.028827617,0.012678429,-0.008180184,-0.029761897,0.013997569,-0.0061409627,0.029879814,0.01989708,-0.051001962,0.019342493,0.07327951,0.07488301,0.05167262,-0.019256266,-0.0133948,-0.020137118,0.020007791,0.09545177,-0.024862468,0.079359844,0.004774678,0.014236291,0.02823583,-0.06218087,-0.0590223,0.058132198,-0.0021344293,0.0020191453,0.0859528,-0.01000703,0.049416117,0.06598779,0.06837956,0.043902647,0.06680879,0.06399309,-0.0001911397,0.028781783,0.009014219,-0.09762319,0.005179749,0.054646797,0.031107314,0.023314787,0.0334934,0.048276354,0.002341883,0.0137198,-0.032590065,-0.07315001,-0.045783754,-0.08245281,-0.007504776,0.01570963,0.050542593,0.06235283,0.020895481,0.023311554,0.042928394,0.045758504,0.03767072,0.010428743,-0.02390725,0.026998982,-0.028118998,-0.05527893,-0.12765574,-0.0014965427,0.00772099,-0.024067767,-0.019961737,-0.0011221581,-0.038388465,-0.051766746,0.040392257,-0.09266378,0.038275365,0.12101861,-0.0072790114,0.027103981,-0.078732334,0.017958712,0.013410823,0.054636095,0.0857317,-4.1608214e-08,0.043833543,-0.04245636,0.022440588,-0.03150396,0.010751757,-0.005744485,-0.0320284,0.020236015,0.019050147,-0.0045355833,-0.028160218,0.064214766,-0.008881818,0.021597845,0.06507409,0.055410314,-0.06626298,0.016807387,-0.041823726,-0.04554044,-0.05959325,0.04290101,-0.058036264,0.009680728,-0.015194416,-0.047250092,0.05795383,0.030339759,-0.06496724,0.015884552,0.039435204,0.05738778,-0.054795917,-0.05935073,-0.0526139,0.040314466,-0.051389884,0.0034613316,0.06365259,0.019823268,0.024092129,0.07292529,-0.06674007,0.04675554,-0.07842098,0.06543075,-0.056296818,0.0022131943,-0.04018474,0.027197087,0.08471213,-0.04939766,-0.097703755,-0.06501148,-0.085926525,0.017991858,-0.01647667,-0.007044647,0.0050851395,-0.00075946585,0.035682634,-0.00951924,0.16026711,-0.074010976 +2.7.1.239,"The enzyme, characterized from the halophilic archaeon Halopiger xanaduensis, participates in a non-carboxylating pentose bisphosphate pathway for nucleoside degradation, which is found in some halophilic archaea. cf. EC 2.7.1.212, alpha-D-ribose-1-phosphate 5-kinase (ADP).",384,1.0,-0.0039395583,-0.043027338,-0.05820928,-0.036722075,0.0904505,-0.029410368,-0.023028705,-0.0041975896,0.066745415,0.0046628853,0.009988721,-0.06334155,-0.064287595,0.058395218,-0.07711255,0.058414645,-0.08444325,0.00033515613,0.05252387,0.016887467,0.033943567,0.07170883,-0.02673596,0.059399415,0.037748158,0.040000554,0.11775599,-0.08178886,-0.07081397,-0.07257181,-0.016059967,-0.06792525,0.14979264,-0.035189394,0.10547771,0.16041923,-0.029121954,-0.10660859,0.040933907,-0.050660398,0.051395334,0.012145381,0.050948102,-0.06042342,-0.033221528,0.040217333,-0.0560753,0.025726432,0.012665393,0.012212122,0.016774977,-0.08583974,-0.02367678,-0.045465473,0.048412383,0.068872176,-0.032878533,-0.060607847,-0.01015744,0.0077237245,0.08100628,0.030574128,0.017892923,0.008157441,0.01180396,-0.03118339,0.09590226,-0.03354917,0.035010234,-0.0461279,-0.063085206,-0.03860355,-0.024291124,0.018339701,-0.006880371,0.036950655,-0.004418112,-0.09748139,0.035157733,-0.065690145,0.03215379,0.030111011,0.060648724,0.017410519,0.006292191,-0.017162357,0.013878561,0.003961047,0.040371493,0.02913255,0.0273201,0.023272492,0.03872255,-0.11732792,-0.039022062,-0.0044466266,0.021302707,0.030713586,-0.061447054,-0.020324118,0.014262708,0.06547084,-0.065122455,-0.104041204,-0.0372014,-0.011956975,0.017044546,0.06321337,0.037324786,0.04810701,0.028719256,-0.040508173,0.0554338,-0.028431324,0.020557161,0.10311493,-0.020320805,-0.04727818,-0.08955447,0.06792399,-0.074893795,-0.05693834,-0.014329681,0.07805593,-0.04291952,0.05886316,-0.10353503,1.3369624e-33,0.077036746,0.027678996,0.006103239,-0.023975706,-0.0006768813,-0.039226666,-0.0071406737,-0.037222397,-0.052553374,-0.11216032,-0.042766634,-0.026075443,0.029617142,-0.071380325,-0.0140649155,0.004724639,-0.040332273,0.08039541,-0.016506115,0.049008045,-0.0612129,0.055156708,-0.02806986,-0.032739643,0.092762575,0.036352977,-0.04636345,-0.021851422,0.034811344,-0.0053787204,0.0031669312,-0.041022327,-0.11910033,0.072158135,0.10814782,0.013500402,-0.0111296065,-0.07174431,-0.06827825,0.041215565,-0.036846172,0.017249806,-0.036744643,0.01350671,0.015816152,-0.0076197265,-0.004937787,0.034457747,-0.006256201,-0.0035315242,-0.022315172,-0.016716111,0.03269207,-0.033656117,-0.023480281,-0.019638969,-0.032290462,-0.055485576,0.066115975,0.019840434,0.04029791,0.056359783,-0.037346702,0.033083733,0.0010955861,0.015348292,-0.08220544,-0.05208405,0.056740016,0.069889344,-0.016740791,-0.06767111,0.06627721,0.023171954,-0.014640823,-0.031487405,-0.056564722,-0.0022014275,-0.058192775,0.016932705,0.02907943,-0.10439771,0.03000174,-0.054117713,-0.031844296,0.03680433,0.054774854,-0.04311057,-0.0070094103,0.05940312,0.046034504,-0.027748173,-0.051519614,0.043890286,-0.043832127,-1.7620682e-33,0.08560148,-0.1011563,-0.0054638735,-0.01976033,-0.10848236,0.09097241,-0.012543841,-0.08069731,0.041133977,-0.08436099,0.06748696,0.043376118,0.06326699,-0.056426078,0.04322983,0.011550599,0.09473902,0.05605214,-0.013666818,0.007868437,0.046782512,0.055491604,-0.039831188,0.019227352,-0.00446232,0.013428086,-0.017382788,0.017468702,0.08093987,-0.01870705,-0.02374554,0.097856924,0.004644496,-0.05958013,-0.07791846,-0.011501438,-0.03564941,0.0016434165,-0.023094257,0.0102056675,-0.028223759,0.06695263,-0.010564812,0.03606414,0.046182554,0.044320628,0.022923427,0.060901072,0.041855432,-0.05526186,0.028077092,-0.08255059,0.011153875,0.025459768,-0.03486474,0.032246996,-0.03735231,0.10362972,0.010298824,-0.0054490026,-0.080791846,-0.0446601,0.10935649,-0.0005193055,0.05741086,0.02803985,0.0047428412,0.057671074,-0.04004235,-0.037842657,-0.0021203368,0.021113072,0.041547447,0.08052482,-0.056948494,0.020681687,-0.055447083,-0.029750612,0.051753283,-0.08243528,-0.056737047,0.026532989,0.010459602,-0.014187704,0.00048807153,-0.083006755,0.065858565,0.054324873,-0.08084959,0.04083964,-0.04429673,-0.028475853,-0.04149662,-0.017447103,0.045092724,-3.5542723e-08,0.032919306,0.012446419,-0.008930847,-0.041357856,0.05163109,0.03995091,0.08368328,0.03276405,0.09871983,-0.025413977,-0.030566582,0.07517096,0.05827299,-0.017682642,0.03819217,0.062100846,-0.013969611,0.0050793267,-0.030163178,0.004429477,-0.029054148,-0.021169918,-0.044945106,-0.0062994966,-0.026072163,-0.021670146,0.08780146,0.07885771,0.023886658,-0.05992058,-0.044953626,0.034535132,0.036957126,-0.042722,0.0025140767,0.079225555,-0.06357012,-0.05236055,-0.004202495,0.06888103,-0.07194437,-0.0047175228,-0.073024504,-0.010353707,-0.042082768,0.055303473,0.06679979,0.0153249465,-0.059873607,0.0072919596,0.033028744,0.00011376517,-0.01591049,-0.048308868,-0.025215065,-0.012649442,0.045277543,-0.077671856,-0.020526512,-0.019077603,0.06285929,-0.053781144,0.13727106,-0.029166864 +2.7.8.48,"The enzyme from invertebrates, best studied from the fly Drosophila melanogaster, is common in arthropods, worms, bees, spiders, and scorpions, and has also been reported in deep-sea mussels and some sea snails, as well as protozoans and oomycetes. Its product, ceramide phosphoethanolamine, is the main sphingolipid in cell membranes of arthropods, such as Drosophila and Musca. The invertebrate enzyme requires a Mn(II) cofactor. In mammals the activity has been shown to be catalysed by members of the EC 2.7.8.27, sphingomyelin synthase, family, such as SGMS1, SGMS2, and SAMD8.",384,0.99999994,-0.05182141,-0.050916284,-0.07097444,-0.03077578,0.06986147,0.013580803,0.0058473293,0.01884875,-0.015478529,0.030371888,0.06433109,-0.092161395,-0.05513378,0.070000984,-0.0011823353,0.1366368,-0.045625128,-0.033843264,0.01731094,-0.0140924575,0.083867185,0.038963843,-0.030671561,-0.051296946,-0.027005281,0.030071562,0.035251282,-0.068273775,-0.020985711,-0.055185545,-0.0051334663,0.0034957929,0.07758302,-0.055498067,0.036557544,0.059926998,-0.031935036,-0.03337382,0.008467232,0.0009363505,0.038996115,0.039541185,-0.010858566,-0.075902656,-0.0863594,-0.011993905,0.04052625,-0.018213106,0.028538343,0.025289472,-0.043264244,-0.10896568,-0.018996969,0.039575595,-0.02912163,-0.00994563,-0.12598349,0.015125579,-0.024661807,-0.067424834,0.022538314,0.04462348,0.0483735,0.016594477,-0.0045020566,-0.033320315,-0.014434438,-0.09626121,-0.023562869,-0.033316143,-0.042697567,-0.0682717,0.009855586,0.031452224,0.0011895385,0.0856716,0.06369097,0.005691455,0.062237617,-0.052054524,-0.05105205,-0.043278262,0.041746695,0.061667208,0.08452866,0.0678976,0.01643589,0.0304288,0.0106601985,0.043230053,0.05536249,-0.039773524,0.022950336,0.033106517,-0.029097535,0.08231785,-0.039615847,0.07065467,-0.0047116713,0.00035082822,-0.00043053148,0.06223788,-0.034010448,-0.07433081,0.0042879637,-0.016248392,0.044532884,0.06183861,-0.012090867,0.019784681,0.028600246,0.025752496,0.09339834,0.057111993,0.021466825,-0.0053797164,-0.025501812,-0.06317031,0.05510056,0.024309777,0.051019147,0.038650665,-0.011890953,0.044406872,-0.031676356,0.06642434,-0.1301422,1.7383403e-33,0.05264743,0.027427614,0.014572903,-0.03842596,-0.056901213,-0.070023574,-0.06637422,0.035187125,-0.03809608,-0.05628454,-0.12297292,-0.037412163,0.060905028,0.06062803,-0.010412913,-0.012844745,0.025274353,-0.0354142,0.160465,-0.008153897,-0.020025142,-0.037827883,-0.023549728,-0.07036597,0.05747703,0.063884154,-0.036376517,-0.03326664,0.02621634,0.006803119,0.03147066,-0.113569014,-0.06036264,0.06361725,0.011375688,0.042635933,-0.020779558,-0.051801637,-0.08174718,-0.025170844,-0.005745245,-0.022605577,-0.06741312,0.023930507,0.040631257,-0.09229433,-0.11151951,0.05042095,0.088748604,-0.03692208,0.0146748135,0.005744007,0.10426893,0.02567345,-0.03000162,0.014673343,0.014201535,-0.026551643,-0.008044659,0.009563243,-0.06443119,0.075056486,-0.014119416,0.052894436,0.06775273,0.023988977,-0.058541782,-0.078269914,-0.1203054,-0.02993666,-0.015111103,-0.073816806,0.07504763,0.0069684573,-0.044505615,-0.03699876,0.042890627,-0.059871215,-0.03879247,0.024511017,0.034912936,-0.048959117,-0.004271397,-0.042005613,-0.03290695,0.022694616,0.00247486,-0.06815218,0.024911975,0.030824125,-0.021325452,-0.102501296,-0.08035203,0.018412344,-0.050381552,-2.6255452e-33,-0.0113823665,-0.024871033,0.006466335,-0.07243051,-0.056295563,0.069047764,0.06740275,-0.020873228,0.018631862,-0.036637723,-0.044695787,0.031157685,0.07200276,-0.09484249,0.03063781,0.046152916,0.036722697,0.030782025,0.106512584,-0.09627017,-0.006132495,0.17588334,-0.0006764537,0.08901726,-0.02176684,0.022732968,0.037645813,0.108430885,0.0012619153,0.012259416,0.012397763,-0.004294416,0.024066035,-0.04598747,-0.023236997,-0.0022229382,-0.061758906,-0.041391537,0.10556058,0.021536145,-0.031105751,0.008810874,-0.0016563259,0.0042653293,0.061945662,0.108351335,-0.05548736,0.02616621,-0.020431029,-0.04993209,-0.050531253,0.045125537,-0.02172357,-0.032997515,0.04375087,0.04589447,-0.00042069124,0.057478186,0.06614662,-0.07928392,-0.01174301,-0.030986024,0.021962658,0.038508564,0.009087209,0.108798265,-0.030824164,0.04850166,-0.030748755,0.03165209,-0.015236083,-0.0017897699,-0.05451624,0.013256298,-0.043022405,-0.031381384,-0.016664468,0.019705769,0.08922902,-0.008271038,0.012793567,0.0428912,0.06529617,-0.03441414,0.031697404,-0.035213154,-0.023228273,0.06867833,0.042778775,-0.019620597,-0.0015383951,-0.06559564,-0.0623395,0.013512558,0.079477854,-4.1390187e-08,0.07100213,-0.043512,0.04260357,-0.09488658,-0.020125525,-0.008533949,0.042033173,-0.03726932,0.046396457,-0.050225683,-0.009928961,-0.020359268,0.047425352,0.0069898483,0.096007116,0.054473136,0.011625737,0.011533151,-0.04561958,-0.052717425,0.0090003535,0.010767101,-0.089252785,0.07420691,0.024740601,-0.044319306,0.016630426,-0.00035739297,-0.03105784,0.056283485,-0.08241979,0.060501963,0.03822513,-0.020402983,-0.023832543,0.012126462,-0.020682385,-0.056840286,-0.0183692,0.053794224,-0.02250998,-0.03684544,0.02103278,0.0015900922,-0.026995324,0.0045033223,0.042349134,0.0016584687,0.014423319,-0.021846514,0.0031078972,0.03225861,-0.028821068,-0.05355724,-0.13511263,-0.032838263,-0.065635934,-0.063478895,-0.04684197,-0.07121401,0.042400133,0.052406065,0.12073155,-0.04904915 +3.1.1.120,"The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme exhibits catalytic activity for the hydrolysis of several lactones, including L-fucono-1,4-lactone, D-arabinono-1,4-lactone, L-xylono-1,4-lactone, and L-galactono-1,4-lactone, but L-fucono-1,5-lactone is the best substrate.",384,1.0,0.05706795,-0.0820659,-0.045115683,-0.026538305,0.08666049,0.06119411,-0.1269431,0.033330534,0.016265007,-0.057729013,0.018225467,-0.08811071,-0.04957426,0.007868601,-0.0616943,0.13296565,-0.06807235,0.07317749,-0.03600025,0.05108012,0.08503706,0.029565658,-0.002278199,0.07946778,0.05996928,-0.048195865,0.023358036,-0.004087209,-0.04062855,-0.09806221,-0.037504178,-0.036346644,0.0725223,0.0015391654,0.029005691,0.085158676,-0.038540754,-0.052897986,0.13895574,-0.008661485,-0.0065380433,-0.045651488,0.025911698,-0.07736392,-0.042039495,-0.018776838,-0.0002121721,0.049766157,0.072742105,-0.003278318,-0.04314987,-0.038702633,-0.03407158,-0.014195409,-0.01887378,0.016222661,-0.012318763,-0.07476301,-0.020735776,0.06637789,0.07049796,0.06883411,-0.015247265,0.045988582,-0.011447028,-0.061331622,0.026848752,-0.058005255,0.00097389653,-0.0072042514,-0.03069613,-0.09887291,0.019986017,-0.05766646,0.078555204,0.07378891,0.019354269,-0.033275165,0.03045663,-0.037483253,0.06619999,-0.028003978,-0.006512164,0.043546826,0.008240515,-0.061886005,0.018007107,0.002108594,0.09138859,0.025807457,0.026769707,0.0036281678,-0.043724336,-0.042500664,-0.01900963,0.02304308,0.031203242,0.027628293,0.05904741,-0.015384385,-0.112790495,-0.018708088,0.02063728,-0.06972726,-0.03294714,-0.02469316,0.06363174,0.06896147,0.09671787,-0.1006066,-0.019053655,0.007282519,0.027390992,0.054629467,-0.04232984,0.053709786,0.09151866,-0.09410928,-0.042911734,0.031424392,-0.022427505,-0.004135034,0.05089885,0.042078838,-0.034766026,0.017120497,-0.02466431,-8.710286e-34,0.046585582,0.033446535,0.004854527,-0.059486777,0.056003317,-0.027898256,-0.08994111,-0.044771545,-0.05402499,-0.024251891,-0.012332615,-0.0063356804,-0.014871967,0.033923417,-0.013613436,-0.012886299,0.031883515,0.008513201,0.0007672201,0.01595306,-0.02835105,0.010524204,-0.06595494,-0.0011222209,0.043646302,0.066034,0.09867039,0.037643977,-0.002708911,0.000891789,-0.00033742614,-0.075149335,-0.10323262,0.014211856,0.03455666,0.055669915,-0.087663494,-0.020882817,-0.01929502,-0.0075028394,-0.0042925077,0.03452428,-0.084528215,-0.020535454,-0.016731327,-0.047027625,-0.055583697,0.102641806,0.030882375,0.05589443,0.0337681,-0.06784568,0.032791,0.039521288,-0.017071623,-0.055155028,-0.041927617,0.02501582,0.021357298,0.010269732,-0.028192697,0.0499687,-0.017958272,0.040060904,0.03132778,-0.048128728,0.0021605673,-0.0024524783,0.061087254,-0.013687456,-0.057375904,-0.034817286,0.035798613,-0.022199387,-0.03563865,-0.030909684,-0.037363864,-0.049006753,-0.029329563,0.065329835,0.015673265,-0.065291375,0.028154435,-0.025050366,-0.06244277,0.04134072,-0.060170602,-0.062226262,0.061415575,0.026644776,-0.0052354434,-0.06247978,0.024147497,0.038848963,0.009003751,-6.575431e-34,0.061131988,-0.094609916,0.093227684,-0.02948172,-0.09030559,-0.0060177413,0.0052154553,0.029414635,-0.012570398,-0.010013387,0.044675816,-0.05460643,0.04043509,-0.059306823,0.021215077,0.07172285,0.05589156,0.024024678,0.0012206984,-0.020816002,0.012405325,0.12314575,0.024777107,0.033462252,0.08984107,0.03072367,-0.037371125,0.054812565,-0.0046941293,0.039043814,0.04846172,0.01602248,0.060898565,-0.03899458,-0.014806819,0.03223409,-0.07880517,0.027220042,0.09739705,0.042134166,0.018377643,0.03386831,0.036428694,-0.008625905,-0.009402502,0.08521304,-0.027126823,-0.030543236,0.0692332,-0.0078022485,0.03813368,-0.03124494,-0.026924787,-0.017067792,-0.0014434847,0.07128119,0.015478296,-0.0013259599,-0.084983364,-0.046930727,-0.07703542,-0.05543151,0.013994627,-0.044768363,0.025143195,0.06565319,-0.046082765,0.037299708,0.016825194,-0.037213773,0.06680963,0.060827717,0.02835653,0.11385198,-0.079103544,0.06579344,-0.12838258,-0.07721628,-0.050589453,0.038701937,0.032408983,0.006761492,-0.010683887,-0.021002535,-0.004397968,-0.11275785,-0.010996852,0.11284049,-0.020961128,0.019927578,-0.010200128,-0.06485521,-0.04918735,0.027977204,0.06367875,-3.931128e-08,0.08099426,-0.06651081,0.038403273,-0.021607412,-0.00693375,0.008055497,-0.011793518,-0.007650855,0.08209352,-0.0047428044,-0.0694899,0.10135675,-0.046216883,0.006639628,0.0010496071,-0.013546691,-0.021999754,-0.00763171,-0.023674455,0.0105467215,-0.08665157,-0.052328296,-0.060862035,0.019661136,0.011644372,-0.05836321,0.010669555,0.06239982,0.011088104,-0.0713486,0.035715193,0.06762334,-0.021070287,0.0069057117,-0.059790067,0.03820282,-0.10246406,-0.061425462,-0.053058088,0.12188725,0.048485808,0.009686899,-0.044869944,-0.04169116,-0.054640815,-0.029182034,-0.046268035,0.042395536,-0.0302543,0.02717173,0.043990366,-0.014358885,-0.018369272,0.037343465,-0.02653245,0.018665511,0.031007143,0.025549617,0.012748214,-0.061909378,0.008421753,-0.01152821,0.20886795,-0.09873361 +3.1.3.109,"The enzyme, characterized from the halophilic archaeon Halopiger xanaduensis, participates in a non-carboxylating pentose bisphosphate pathway for nucleoside degradation, which is found in some halophilic archaea. The enzyme requires both monovalent and divalent ions for optimal activity.",384,1.0,0.0011727363,-0.060598947,-0.06093236,-0.040936906,0.07092454,-0.0077867773,-0.020204432,0.012340151,0.06852568,-0.014624816,0.019227793,-0.08498,-0.050735135,0.07727843,-0.05788349,0.04554281,-0.07524847,-0.019641118,0.047568288,0.0062586893,0.05949749,0.04959862,-0.02680516,0.060966752,0.0143996,0.0405377,0.09704593,-0.13676517,-0.044901688,-0.07383917,-0.023650318,-0.052803744,0.13744764,-0.02734653,0.094396114,0.13355467,-0.027246987,-0.08950464,0.04216214,-0.04744092,0.058092017,0.025650479,0.035693835,-0.07675992,-0.03655853,0.027462749,-0.0030905046,-0.0129884435,-0.011705164,0.036222972,0.0162977,-0.10973981,-0.02749171,-0.01574609,0.052754905,0.07853619,-0.05257848,-0.05397297,-0.027356043,0.015145155,0.07844069,0.050689206,0.033664983,-0.0048701945,0.01966919,-0.07059166,0.067139186,-0.04010903,0.033482328,-0.07640906,-0.03569469,-0.042082727,-0.045221727,-0.01374154,0.008987951,0.039181594,0.037403654,-0.09272636,0.013219256,-0.050947472,0.015485348,0.026698297,0.07536481,0.047953285,0.036869776,-0.0027857714,0.03906756,0.0005277711,0.049213547,0.030591926,0.03710119,0.024889661,0.026160473,-0.1133213,-0.0049982015,-0.0042276047,0.035294324,0.005664163,-0.04112376,0.005783678,0.05391726,0.054853585,-0.06467109,-0.107747994,-0.055964753,-0.008175312,0.031538103,0.05265929,0.022330692,0.056139,0.055271175,-0.060856424,0.06438545,-0.01827555,-0.019274559,0.098360844,0.0032985709,-0.029210908,-0.10587473,0.088420115,-0.06440445,-0.049939375,0.0047665513,0.0605827,-0.05232017,0.077595495,-0.11197316,4.1182034e-33,0.061324697,0.02949831,-0.02086766,-0.04891451,-0.013998712,-0.03119988,-0.0016979087,0.005051951,-0.081235684,-0.13715598,-0.02710057,0.005488485,0.0115847,-0.05808405,0.0061521637,0.011338016,-0.027157905,0.07472335,-0.0008533759,0.02810273,-0.051717766,0.03231761,-0.03164614,-0.031956427,0.102570005,0.025397172,-0.033729333,-0.0237375,0.028140739,-0.01857862,0.02790312,-0.055315368,-0.10062197,0.078624085,0.12054363,0.034758158,0.0012991182,-0.065401636,-0.11327366,0.006302248,-0.040862177,0.031309363,-0.051440008,-0.017092932,0.027707947,-0.048678804,-0.013746048,0.020884627,0.00056730065,-0.009507192,-0.033896483,-0.001294787,0.049703978,-0.019983318,-0.023755535,0.003007157,-0.008410033,-0.044786453,0.05460405,0.005322118,0.0313683,0.037414942,-0.025342872,0.023865197,0.030142,0.02596296,-0.08763262,-0.012248686,0.04534914,0.07075999,-0.05577534,-0.07744641,0.019287385,0.025476195,0.012211979,-0.048083663,-0.07568111,-0.0072716624,-0.014102978,-0.030803116,0.057808425,-0.08491323,0.05051201,-0.0543868,-0.06264307,0.022501877,0.045693003,-0.02060165,-0.012538283,0.07076529,0.057628993,-0.024682632,-0.042534567,0.036032673,-0.029349253,-4.2426438e-33,0.06726243,-0.110662565,-0.03805165,-0.019573634,-0.081544265,0.07940858,-0.026415322,-0.10569284,0.019622535,-0.091366954,0.0413548,0.018972185,0.064011015,-0.05082559,0.033742595,0.039871525,0.102101676,0.06278379,0.003369677,-0.0056443233,0.022247953,0.07190538,-0.017234296,0.0046479492,-0.021738512,0.015586451,-0.0076615573,0.027195401,0.08787154,0.010219266,-0.06193996,0.07142689,-0.0026147715,-0.07796537,-0.09057129,-0.001534837,-0.018301202,0.001859767,0.009254827,0.023158478,-0.0022064624,0.03926168,0.017739119,0.039207734,0.04187895,0.038710628,-0.012795916,0.056058154,0.04361286,-0.03067727,0.027346846,-0.086681396,0.00861672,0.02170895,-0.007999897,0.027802471,-0.025253573,0.0713154,0.0063702785,-0.020377394,-0.072556846,-0.052715655,0.084599435,-0.0084621515,0.031361163,0.0045554126,-0.026627462,0.06531786,-0.03511774,-0.0648717,0.022500241,0.022169765,0.046915136,0.08032105,-0.058184445,0.013584954,-0.030491825,-0.052151684,0.058212336,-0.09049704,-0.03675181,0.029881096,0.036879964,-0.044360176,0.027028767,-0.09164323,0.06399195,0.061268676,-0.0739617,0.028285397,-0.028915834,-0.023336614,-0.014784246,-0.027472861,0.056196164,-3.456885e-08,0.008733942,-0.023326067,-0.022585385,-0.022107402,0.0135977175,0.04385777,0.08418029,-0.010980665,0.08391965,-0.019347537,-0.02148595,0.05994412,0.060259134,0.007351503,0.062391754,0.05486163,-0.010160714,0.020016856,-0.044752423,-0.0012074554,-0.063271664,-0.011300269,-0.063554555,-0.02403142,-0.033374343,-0.0024964192,0.07154679,0.07134711,-0.020399278,-0.038975373,-0.06161841,0.057869088,0.026226586,-0.041886877,-0.0277624,0.064259596,-0.034067623,-0.029244259,-0.009719181,0.031486984,-0.03928903,0.010788323,-0.10826488,-0.010015124,-0.009866019,0.058546845,0.060647905,0.027926521,-0.055435807,0.046109315,0.054907266,-0.033595044,0.026329366,-0.046601657,-0.024950884,-0.009859406,0.07667445,-0.07242127,-0.024613805,-0.021989949,0.07824006,-0.04383108,0.16815464,-0.050012838 +3.2.1.218,"The enzyme, originally characterized from the bacterium Agrobacterium tumefaciens, is specific for disaccharides that contain a 3-dehydro-alpha-D-glucose at the non-reducing end such as 3'-dehydrosucrose and 3'-dehydro-alpha,alpha-trehalose. It has no activity with disaccharides in which the glucose is in beta conformation, and greatly reduced activity with disaccharides with an unmodified 3' position.",384,0.99999994,-0.058447033,-0.09584688,-0.10647347,0.005456544,0.033660375,-0.016047277,-0.026444867,-0.002594519,0.039266087,0.024775587,-0.008812479,-0.006732382,-0.08196915,0.007537258,-0.044974092,-0.018799553,-0.034763128,-0.019520752,0.021602886,-0.055330154,0.05528505,-0.021979842,-0.011643173,0.010623314,0.1007519,-0.022229958,0.031219969,-0.023659615,-0.03562889,-0.06440642,-0.00064181385,-0.056478612,0.11251832,0.012576817,0.048241038,0.13273346,-0.055660214,-0.041667625,0.030286519,-0.034362007,0.05937776,0.02892367,0.0029741623,0.035011686,-0.02935795,-0.028777894,-0.078428164,0.05118582,0.022878194,-0.01882115,-0.032451376,-0.05566727,-0.039919235,0.04696567,0.04729635,0.014994335,0.016515266,-0.027500072,-0.047099724,0.026118647,0.079746194,0.0018217386,-0.04676663,-0.0008495393,-0.011821614,-0.057601426,0.044413347,-0.11813164,-0.03609303,0.04744769,-0.07195844,0.01215533,-0.005856355,0.01097675,0.017365685,0.0005540627,-0.015400477,-0.019507665,0.011155427,-0.010368039,0.049004592,0.026986796,0.062030744,0.10435036,-0.009855334,-0.07307639,0.006455865,-0.043759417,0.063015364,0.020535473,-0.028133193,0.021611337,-0.013578807,-0.02329473,-0.07522728,0.0056305067,-0.017998338,-0.03099473,0.030516598,0.0026306307,0.024794051,0.054746382,0.02793755,-0.053664412,-0.10301012,0.06719437,-0.00841977,0.063987695,-0.008509556,0.09473539,0.027952898,0.0040738387,0.07742682,0.051979218,-0.08984992,0.034715727,0.033950675,-0.11882323,-0.0007148219,0.0038465424,0.0102683585,-0.05179158,0.13091505,-0.003972718,-0.043394767,0.08714841,-0.07481026,3.0542135e-33,0.034823183,-0.030249929,0.0055540972,-0.019506952,0.062877655,0.030771725,-0.1255255,0.048839424,-0.04473724,0.055763252,-0.08571578,-0.019147953,0.048808772,0.054286927,0.007623436,0.008636646,0.022856688,0.014484671,0.038962096,0.046285503,-0.00066594523,0.042754218,-0.05115077,0.027368385,0.05072339,0.019661773,-0.055908397,0.029009828,0.059429783,-0.003146149,0.09019414,-0.068522505,-0.06526841,0.0049850247,0.088182524,0.0041174437,-0.076704256,0.021278482,-0.021409398,0.05717315,0.07248375,0.041078318,0.07018189,-0.05701578,0.02657952,-0.02402093,0.06058107,0.021624697,-0.017734297,0.07638935,0.05422885,-0.0075361216,0.049503457,-0.033144217,-0.0005144985,0.051017877,0.008357255,0.052315086,0.018545551,-0.00754099,-0.021686267,0.016557997,-0.02535885,-0.024164757,-0.027670704,0.013672806,-0.06423752,-0.049844928,-0.021696266,0.030229544,-0.11596921,0.016573897,-0.0049074097,0.036862873,0.036075156,-0.07900613,-0.055313636,0.032720525,0.029086217,-0.06869621,0.0043709883,-0.026739452,0.027375406,-0.034593806,-0.10697187,-0.016939297,-0.036082968,0.0014569993,-0.032625318,-0.047862243,0.021019109,-0.0022239625,-0.1178564,0.052247204,0.06720292,-4.4887097e-33,0.050568946,-0.11755135,0.051269166,-0.054965705,-0.0314091,0.056066982,0.006190857,-0.01696259,0.06172572,-0.021188404,0.13244349,0.052512668,-0.02821718,-0.052061055,0.06486574,0.044935267,-0.033265226,0.023925072,-0.11478616,-0.033030305,-0.01734642,0.12026571,0.036567356,-0.059232578,0.03087333,0.00022233816,0.008149459,0.07157665,0.039599523,0.01938712,0.008542052,-0.0041268216,0.016459875,-0.03131285,-0.11685635,0.014037007,-0.07521958,-0.054797508,-0.029777946,0.028291965,0.052197695,0.08838953,0.030544683,0.046425886,0.03141412,0.062015153,-0.05891354,0.02214256,-0.014930203,0.003073578,0.008099129,-0.062105328,0.0152405435,0.042455167,0.06004682,0.05913085,0.009887726,0.010170164,-0.07324595,-0.028898876,-0.021374464,-0.039801672,0.093304016,0.008898581,0.045354556,0.024783354,-0.061135784,0.12563269,0.060805075,0.0033961702,-0.016011251,0.017208973,-0.08503352,0.019237112,-0.026758075,-0.0024422577,-0.09658568,0.0033108802,-0.020033117,-0.02359978,-0.044834044,0.048825935,-0.036494464,-0.03489163,0.016666524,-0.08524368,-0.0065848413,0.0917056,-0.022329077,0.10020729,-0.017640857,0.007658257,0.0045666946,0.06884313,0.09016745,-4.3587026e-08,-0.0007017316,-0.043746226,-0.055369694,-0.029795075,-0.03043573,-0.0065550297,0.023080949,-0.0037406427,0.025985064,-0.014391967,-0.0241979,0.10278452,-0.061603993,0.05038598,0.02705673,0.00890732,-0.03241829,-0.018363005,-0.045971047,0.03075973,-0.05352317,0.0003681055,-0.14706036,0.038487352,0.0075433305,-0.06361607,-0.012912925,-0.03273675,-0.10688602,0.014293168,-0.015537176,0.09697543,-0.009285322,-0.05028368,-0.09290999,0.013387933,-0.05391491,-0.056028437,-0.040339246,0.022851579,0.10318126,-0.005022819,-0.08882436,0.010685312,-0.07386254,0.045194108,-0.0039006823,0.049162634,-0.014560719,0.036252897,-0.016641978,0.022537556,-0.07823747,0.0010580715,-0.074349366,-0.0093227755,-0.04809772,-0.040092897,-0.032766923,-0.03689489,0.064582385,-0.036142882,0.15610771,-0.028765056 +3.2.1.219,"The enzyme, characterized from the bacterium Erwinia rhapontici, is specific for palatinose.",384,1.0,0.010254282,0.009087766,-0.12530516,0.010234243,-0.016440142,0.06955265,-0.074208066,0.05916279,0.021300316,0.011099715,-0.017755395,-0.0074591856,-0.056749787,0.09749338,-0.055615246,-0.009955046,-0.0160939,-0.0016331982,0.0043965606,-0.021737501,0.09637963,0.06733801,0.066713,-0.049277708,0.019097727,-0.0521501,0.03860382,0.03570985,-0.038139693,-0.046946898,0.01369959,0.03370111,0.10185224,-0.08620452,0.10036959,0.0995405,0.07324847,-0.09092506,0.12284384,0.009227652,-0.009497925,0.024301833,0.0062259007,0.058977842,-0.023574488,0.012519111,-0.03344258,0.032224335,0.04487274,0.0054497505,-0.11982012,0.013821474,-0.038853873,-0.034334477,0.03662023,-0.014098281,0.05204047,-0.029508436,-0.0076508042,-0.021654638,0.013287894,-0.031202938,0.057038743,-0.0011342586,-0.061648045,-0.04187914,0.033246927,-0.0659719,0.06263328,-0.0010015253,-0.03948351,-0.07138593,-0.004677124,-0.0030114844,-0.044834986,-0.058037154,0.020774458,-0.060742088,-0.029977534,0.0087578995,0.006329245,0.012235887,0.023710951,0.0038748884,0.0012694758,0.051497895,-0.011864752,-0.030840563,0.055026535,0.08132178,0.033122115,-0.031265926,0.008440039,-0.06701539,-0.068208605,0.00820594,0.017009664,-0.01790862,0.062287763,-0.052228566,-0.0048407344,-0.052247707,-0.009841285,-0.035004627,-0.017537776,0.0012716247,-0.022633625,0.044459905,0.009364655,-0.0013540699,-0.023518179,0.061463386,0.0037579362,0.031902436,-0.015748566,0.061047558,0.006187923,-0.0503489,-0.050663643,0.057617098,0.0213397,-0.027631754,0.039122023,0.07480262,-0.043294787,0.05849182,-0.14148824,-8.5806395e-34,0.026796961,0.05119554,-0.0019590172,-0.012826886,-0.02745945,-0.030704278,-0.1039738,0.049908016,-0.09983849,-0.006113585,-0.1052389,-0.0704318,0.037379738,-0.009314438,-0.028736819,-0.018296415,-0.063155286,0.024640022,0.012142464,-0.036659077,0.028077485,0.029434625,-0.04670893,-0.03870952,0.019148458,0.04125075,0.08400384,0.042598236,0.056072105,-0.058338534,0.07590566,-0.044230033,-0.015400448,0.02366856,0.091209225,-0.007029414,-0.015902318,-0.011439614,0.0038701969,0.01687277,-0.035880618,0.056174077,0.011602862,0.0094873775,0.092353,-0.091980085,-0.07916454,0.065304525,-0.0072004776,0.027104294,-0.013608688,0.021457776,0.1534648,0.069889285,-0.049580056,0.030197056,-0.010217875,0.025664305,0.03670558,-0.016237745,-0.012854273,-0.027300399,-0.047996946,-0.03617153,-0.018311135,0.04557495,-0.013793582,-0.04951175,-0.01662811,0.111133784,0.00483124,-0.013105876,0.0400676,-0.0036084235,0.047420662,-0.008552763,-0.095972046,0.01960636,-0.036248874,0.0069640283,-0.03685502,0.0012072109,-0.025917595,-0.009932115,-0.09753439,-0.03430277,-0.046195846,-0.045278817,-0.007540965,-0.03192563,0.09278149,-0.115283206,-0.0851446,0.050208654,-0.024630373,-3.7942437e-34,0.10479146,-0.07538576,0.049283087,-0.056630816,-0.015551231,-0.00068998855,0.021152783,0.0009293114,0.0018315047,-0.028273966,0.076745614,-0.019598717,-0.013604779,-0.055060163,-0.033102576,0.12825567,0.012048172,-0.007134247,-0.04505294,-0.02100902,-0.10541316,0.0068049286,-0.03232722,-0.052377865,0.02770168,0.0072093657,-0.0061974414,0.061418213,-0.017671362,-0.009216006,0.02766607,-0.055154234,-0.049393456,-0.025035217,-0.024358632,0.052923154,-0.047581114,0.0062863277,-0.01968558,0.023323111,0.016835846,0.06778266,-0.04484576,0.09787135,0.029264256,0.080524825,-0.0761023,0.045348305,0.016318131,-0.018354962,-0.022892313,-0.025899446,0.04627787,-0.015213553,0.0108290855,0.04345611,0.065920204,0.027975025,-0.08611239,0.013346591,0.023708297,-0.029884838,0.08620364,0.07327201,0.047329612,0.073888816,0.010464405,0.048009,0.041555554,0.05006957,0.06694207,0.050960448,0.0071396236,0.06399357,-0.056675136,-0.007084642,-0.055053934,-0.07123111,-0.06912615,0.026616031,0.08731872,-0.039462794,-0.0028685154,0.03260225,-0.033217456,-0.021885693,0.045959365,0.080402024,-0.0031030828,0.04120338,-0.026198676,-0.04404482,-0.047206964,0.06729656,0.09777008,-2.4124747e-08,0.032496266,-0.058921408,0.008728135,-0.09528933,-0.0019232834,0.01320294,-0.03910313,-0.02515581,0.010084158,-0.0035554734,-0.073123775,0.05461675,-0.07324684,-0.019908952,0.0048806327,-0.016409473,-0.046156477,0.010616191,0.01201989,0.015499473,-0.0027677042,0.009531258,-0.12562752,0.08756631,-0.0005173893,-0.0181475,-0.017582364,0.0042393683,0.0087859295,-0.023224944,-0.04081134,0.06167905,0.04018552,0.029364841,-0.11744997,0.061735038,-0.059321094,-0.046850435,-0.10736335,0.05376166,0.117453374,-0.012099212,-0.05875552,-0.018101975,0.039961718,-0.0013308935,-0.027988045,-0.054514445,0.06325473,-0.0023873723,0.08695326,0.06006472,-0.043289416,0.023159048,-0.09134034,0.045021165,-0.081299715,-0.06279269,0.025161272,-0.0068401583,0.055612408,-0.0016992108,0.19363938,-0.0599537 +3.6.1.76,"The enzyme, characterized from the methanogenic archaeon Methanosarcina mazei, belongs to the Nudix hydrolase family (a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to a moiety). Its main purpose is to provide the substrate for EC 2.5.1.129, flavin prenyltransferase.",384,1.0,-0.07725748,-0.034580797,-0.087467186,-0.035809048,0.059697337,-0.0067156786,-0.072011486,-0.03141598,0.016028345,-0.047196936,-0.013878599,-0.1059596,-0.083559036,0.023805777,-0.08220422,0.030400736,-0.1030455,-0.00222974,0.011583075,-0.050352793,0.088087894,0.06828765,0.023295706,0.019863734,-0.051593848,-0.05917767,0.021878872,-0.01639114,0.023351666,-0.073378734,0.054784816,-0.009431614,0.0691458,-0.057227317,0.0812825,0.13883255,-0.02246168,-0.10011018,0.02758291,-0.015619944,0.09547461,-0.009789707,0.118914485,-0.04955475,-0.07657473,-0.044743806,0.0063818637,0.018361295,0.03625454,0.022706741,-0.08775934,-0.084074914,-0.041272797,0.006874469,0.070725895,0.07789094,-0.041517396,-0.042808045,-0.0156164495,0.030457664,0.050537433,0.03424231,-0.025547193,-0.0004597923,-0.0050753844,-0.02132999,0.034386497,-0.079173595,0.11034538,-0.044739448,-0.03000414,-0.03469774,0.010269061,0.006572153,-0.026815526,-0.040920373,-0.03291038,0.008571235,0.056400083,-0.040308814,0.022355974,0.023671944,0.0526763,0.018661166,0.043589238,-0.026097031,-0.059040047,0.013093601,0.049073078,0.011719764,0.025438797,-0.044626273,-0.021022817,-0.043070264,-0.0472531,0.03033358,0.055980094,0.04329152,-0.037354846,-0.0134112695,0.036009595,0.019833755,-0.05587479,-0.06381418,-0.08329993,-0.047400672,0.09274154,0.07543481,0.025827147,0.03948625,0.0070515424,-0.038821373,0.07852098,0.0075539034,-0.054915424,0.054795306,-0.057854492,-0.08233745,0.039914906,-0.015755845,0.015160197,-0.05340252,0.11095534,0.03382523,-0.005945009,0.01705865,-0.15676522,2.2579843e-33,0.06283264,0.0054180096,-0.05895848,-0.0028651408,-0.022272853,-0.047317673,-0.058498915,0.008588412,-0.049486164,-0.06346728,-0.066984236,-0.017651537,-0.028051075,0.013047545,-0.04153078,-0.05617823,-0.0022963008,-0.007912185,0.019182349,0.004281867,0.0019131636,0.05416246,-0.06808183,0.046312153,0.043441348,0.032091763,-0.08021291,-0.0041520665,0.060372576,0.041239575,0.008073044,-0.07483201,-0.09441681,0.029116241,0.018166866,0.04272165,-0.0581642,-0.05651518,-0.009492833,0.053314015,0.008572408,0.012567618,0.033360682,-0.055557553,0.043706596,-0.0048322617,-0.03228256,0.083988495,0.05324864,-0.0097040925,3.167944e-05,-0.023771444,0.08756031,-0.024810078,-0.043991484,-0.006157293,0.000890065,-0.017753134,0.047058333,0.0556812,-0.013187716,0.032393396,-0.026630186,0.076664805,-0.019712951,0.021817418,-0.0014335602,-0.06950466,0.07981062,0.10013064,-0.071792915,0.002256696,0.038064446,0.04505842,0.06583726,-0.0332864,0.041378856,0.005943588,0.008870428,0.037676584,0.054986972,0.0008035198,0.02475702,0.0049396413,0.00460714,0.013110919,-0.008699691,0.06061932,-0.027740803,0.07365009,0.059163306,-0.08626744,-0.021200953,0.035119135,-0.016226161,-2.6467113e-33,0.048041668,-0.04140758,0.020724833,-0.09102567,-0.106178,0.09010111,0.04440288,-0.026401768,0.044302404,-0.035265777,0.061508995,-0.0058061443,0.04339874,-0.08259224,0.06171696,0.005660398,0.00480308,0.013834632,0.036607698,-0.025288546,0.017441627,0.085160576,-0.07092857,-0.03783305,0.003283025,-0.022545703,0.033684224,0.063614495,0.021510355,0.048293184,-0.10638653,0.010869189,-0.06363683,-0.03317436,-0.060962666,0.024638291,-0.0357089,-0.019999389,-0.06081136,0.010816484,0.056550886,0.061060034,-0.009103479,0.03655964,0.008180078,0.0819704,-0.059802752,0.007499304,-0.040423196,-0.037419133,-0.00402764,-0.046616014,0.0030443405,-0.013486517,0.011013309,0.040197488,-0.010508553,0.073998146,0.025737057,-0.07893106,-0.06581876,-0.054397598,0.03559986,-0.01198265,0.061077785,0.054638915,-0.043834895,0.096368894,-0.029763825,0.02296113,0.06883091,0.007263414,0.04709464,0.07320635,-0.047370683,-0.0086495755,-0.08870736,0.01380244,0.051350918,-0.052478995,0.015844844,0.013389874,0.047274157,-0.08365059,0.05399904,-0.03786132,0.13126922,0.068880334,0.035236318,0.03082503,0.008550368,-0.02369104,-0.09422063,0.008942468,0.0028352034,-3.9443435e-08,-0.004203632,-0.08795273,-0.025635635,-0.03156487,-0.0030074087,0.06436499,0.047162715,0.07875718,-0.0092239175,-0.015050212,0.0028974852,0.073253304,0.04591776,-0.008113032,-0.01984852,0.029113762,-0.0547861,0.04721473,-0.039945766,0.047843657,0.007964535,0.013575783,-0.04639143,0.05427016,-0.06073378,-0.028232902,0.043139853,0.058185484,-0.016974442,-0.103730746,-0.050534524,0.019694623,0.03986026,0.0022946508,-0.14679083,0.01789231,-0.010964076,-0.014513553,-0.046605796,0.03226576,0.025303707,-0.057419334,-0.0035026106,-0.004120806,-0.02139268,-0.005064387,-0.017113222,0.065153986,0.010209621,0.019167885,0.01346566,0.011051295,0.02119358,-0.0333029,-0.06704415,-0.10099922,-0.017206715,-0.020980522,-0.045834787,-0.012595509,0.09920887,0.07073292,0.20452093,-0.043278534 +4.1.99.27,"This fungal enzyme catalyses a key reaction in the biosynthesis of quinolone compounds, converting the benzodiazepine structure into a quinolone structure. The enzyme is also active with (-)-4'-methoxycyclopenine.",384,1.0,-0.052220203,0.051131662,-0.10662938,-0.062408566,-0.018032473,-0.018673664,-0.03170773,0.046133816,0.050712734,0.0018312668,0.0027642928,-0.016959332,0.013994487,0.064400695,-0.039378792,0.093771115,-0.055188324,0.014088322,0.002653979,0.039496955,0.019343147,0.002832424,-0.030920934,-0.030983198,0.042353492,0.023472082,0.057368554,0.055168677,-0.03773146,0.005681624,-0.011619417,0.04384083,-0.00016514969,-0.072608285,0.02066087,0.053431325,-0.05659337,0.010433923,0.094313845,0.0910608,0.0059829466,-0.0070937383,-0.025201486,0.036912344,0.03548916,-0.003134528,-0.026264004,0.05804372,0.01073001,-0.008080643,-0.10965984,-9.3419934e-05,-0.005340235,0.025514208,0.019236222,0.00028371008,-0.07961871,0.01895846,0.023263263,0.08775367,0.06594835,0.0321901,-0.06626396,0.021349926,-0.017972609,-0.0077764336,-0.0047725094,-0.0066317557,0.03939202,-0.07452293,-0.063451774,-0.02800131,0.030694813,-0.07603461,0.04171662,-0.022879926,-0.045478243,0.019136826,-0.022928055,-0.030387165,0.038176104,-0.017650945,-0.059635356,0.059497356,0.089390926,0.02588189,0.03653349,0.028630763,0.059089467,0.08600201,0.03366982,0.00919788,0.0013673079,-0.0894965,-0.08205604,0.04746196,-0.0071024396,0.051511455,0.0494471,0.050721332,0.072273344,-0.00089321757,0.004167408,-0.10117085,-0.095241725,0.01611036,0.119617775,0.11325508,0.016770098,-0.00130596,-0.05444349,-0.017318577,0.04379041,-0.015595747,-0.06830621,0.08709403,0.02899304,-0.056043815,-0.019415146,-0.016282117,0.026537294,-0.012582959,-0.028625729,-0.068374865,-0.022115216,0.055716474,-0.081899054,2.3247261e-33,0.05482208,0.099497296,-0.0052147605,0.013401283,0.045009073,0.020838957,-0.070522115,-0.021868797,-0.107175164,-0.05837969,-0.087466046,-0.029120613,-0.05051837,0.050424542,-0.06000603,0.011616539,0.018271623,-0.022405105,0.03315988,0.004067271,0.07129464,0.040568918,-0.10000815,-0.00298682,-0.016767215,0.0696186,0.0018699882,0.018960759,-0.055291127,-0.0057689087,-0.06695441,-0.010381167,-0.06570758,0.011487563,0.024718573,0.00610711,-0.009096099,-0.026635429,-0.0503886,0.00086341804,0.012539524,0.046477932,-0.022155477,-0.0041767824,0.01848169,-0.003168829,-0.036436394,0.057021853,0.0595535,0.0071911337,0.05911461,-0.010587164,0.0462327,0.013477761,-0.14329016,0.061655104,-0.011172457,-0.020197656,0.0185719,-0.02227441,-0.033297572,0.05577288,-0.027718497,0.0073920623,0.023209007,-0.029513514,-0.03784128,-0.084027655,0.044088613,0.06815719,-0.069583185,-0.01436409,-0.0046513714,0.013967845,0.043810006,-0.035435494,-0.062147122,-0.06431623,0.02314329,-0.015882308,0.06125683,-0.047409393,0.061714973,-0.044265725,-0.03217508,0.0007366608,0.034517433,-0.07448312,-0.015412443,0.041882496,-0.014731016,-0.08757152,-0.019857796,-0.010581364,0.06201903,-3.0336965e-33,0.114902645,-0.08316079,0.06472806,-0.057637084,-0.043719858,0.06835115,-0.04396184,-0.07469749,-0.0047954884,-0.03796224,0.051325336,-0.087818675,0.103604056,0.009591964,-0.011701554,-0.01267668,0.047499433,0.025124352,-0.014402346,-0.042482436,-0.03084905,0.03394455,0.0014918062,0.044589125,0.037386153,0.015462113,0.033487394,0.044883143,0.026313988,0.10163789,-0.084615834,-0.0376274,-0.006976316,-0.01360243,-0.015566233,0.12721889,-0.056354094,0.010991315,-0.008171811,-0.0112237,-0.03715909,-0.07709038,0.03350243,0.05217198,-0.0021079301,0.028679518,-0.046328243,0.023228573,-0.05998519,-0.07736397,0.067144014,0.074130036,-0.043998152,0.0014382049,0.09559411,0.05489592,-0.00015283993,-0.09860039,0.036211565,-0.059636064,-0.07247965,-0.05071079,-0.030787982,-0.069353595,0.08067256,0.025186876,-0.029241169,0.06691423,0.048942123,-0.04792639,0.10910258,0.06386942,0.013843849,0.07860244,-0.05150527,-0.02826937,-0.05499558,-0.07595508,-0.0005638427,0.028997017,0.045353815,-0.06269735,0.00028288434,-0.01683274,-0.11758326,-0.10885065,0.071903855,0.095386244,-0.025017058,0.006530561,0.03217786,0.07770563,-0.04007604,0.06422781,0.072564565,-3.090462e-08,-0.0017981869,-0.06091009,0.0010488703,0.006323013,-0.08066606,-0.0036301634,0.027845051,0.024116553,0.03307719,-0.040374793,-0.0019152544,0.037387777,0.00647189,0.05614691,0.03414422,0.02309771,-0.0135697005,0.049382064,-0.024334697,0.07060913,-0.022896769,0.0006432458,-0.090942934,-0.010220723,-0.006369505,-0.10674015,-0.0054399627,0.038707152,0.01614689,-0.019761387,-0.027912175,0.0003435858,-0.01305292,-0.034637757,-0.09468284,0.052781895,-0.061932348,-0.043566715,0.021223335,-0.064627126,0.1038393,-0.06268861,-0.12086361,0.02918844,-0.09085064,-0.066161096,0.013470935,0.00986679,-0.029936174,-0.008811925,0.0809812,0.046263408,0.053508878,-0.059867438,-0.048125695,0.010234377,0.02078098,0.017071186,-0.014477678,-0.081654646,0.004991584,0.03403246,0.15252966,0.016922198 +4.2.2.28,"The enzyme, characterized from the phytopathogenic fungus Fusarium oxysporum, removes the rhamnosyl residue from alpha-L-rhamnosyl-(1->4)-D-glucuronate or (with lower activity) from oligosaccharides that contain this motif at the non-reducing end, leaving an unsaturated glucuronate residue. Among its natural substrates is the type II arabinogalactan component of gum arabic.",384,1.0,-0.026622916,-0.0032066351,-0.07551327,0.001000461,0.040481444,-0.04037665,-0.019554326,-0.04946487,0.09621804,0.0036621545,0.06706221,0.044663724,-0.03871108,0.045521837,-0.06340329,-0.004015314,-0.020453995,0.050978936,-0.029983202,-0.01278323,0.13514215,0.027454242,0.02791497,-0.00045404144,0.033054754,-0.041780308,0.01846691,-0.038520653,-3.266641e-05,-0.019781705,0.04436623,0.020211468,0.10511515,-0.05784047,-0.028238004,0.10333827,-0.031250972,-0.025497379,0.11238337,0.032600697,-0.0058680247,-0.010360497,0.067529865,-0.028440146,-0.021670895,-0.04880918,-0.048212375,0.07885659,0.06189564,0.030911686,-0.018222941,-0.07373406,-0.015245578,-0.04195097,0.03436022,-0.027214259,0.03088504,-0.02096005,-0.04714364,0.055833686,0.073749356,0.04583334,-0.097150244,-0.007913847,-0.13317865,-0.047772173,0.07817047,-0.043719545,-0.009351388,0.0021619236,-0.06353797,0.03517726,0.009510274,-0.029282788,0.064665996,0.023733256,-0.02539883,-0.04554425,-0.040954705,0.04794324,0.08231949,0.051180117,0.018493151,0.021040093,0.030683221,-0.049820997,-0.019958086,0.0074561695,0.00776962,0.008431455,0.0858864,-0.0005874876,0.017307742,0.026083048,-0.00023533769,0.023203133,0.02930573,0.059048437,0.039675992,-0.026612885,-0.036238037,-0.02975137,0.05512094,-0.07370525,-0.04878146,0.029423712,-0.082298726,0.07371534,0.06670425,-0.04163385,0.0059158527,0.016451042,-0.014175184,-0.050242174,-0.067021444,0.04702641,-0.0074080774,-0.11619979,-0.13739076,-0.025109667,0.022993175,-0.037404776,0.06036789,-0.008516327,-0.021324353,0.014169523,-0.045381602,2.949916e-33,0.035073828,0.039325904,-0.026443744,-0.05637201,-0.015213531,0.00922624,-0.049605083,-0.025513284,-0.038814563,-0.0059545627,-0.059988808,-0.02105075,-0.07968693,0.021143956,-0.02324955,0.059726164,0.015318299,-0.06555775,0.08088239,0.056740172,0.029361896,0.02385124,-0.05708319,-0.027239313,0.009260699,0.054976877,0.005716353,-0.06793661,0.057346195,0.0071389643,0.0550442,-0.06689407,-0.13525508,-0.0046430444,-0.005713656,0.00010282462,-0.11328576,-0.047071204,-0.030158699,-0.043235738,0.032672554,0.075258814,0.0058347387,-0.0023713266,0.04108182,-0.015169146,0.01953238,0.13227233,0.021697277,0.12300368,0.0557525,0.06344983,0.06805581,0.021295415,-0.048449297,-0.043721925,0.024368094,-0.015203639,-0.03817432,0.0675463,-0.031806413,-0.025308512,-0.022224545,0.052065354,-0.076271504,0.0066923047,-0.028068809,-0.037427668,0.01189601,0.019211395,0.02910386,-0.049327977,-0.029458618,0.07698382,-0.05604725,-0.041295797,0.0241366,-0.005416053,0.030471621,0.040207874,0.022932818,0.032599524,-0.02023787,-0.033824917,-0.13717319,0.03656385,-0.014903039,0.01819176,0.021801308,-0.024896314,-0.038204364,-0.013895401,-0.030702326,0.05606905,0.028579429,-3.6180126e-33,0.094404,-0.08053675,0.032175083,-0.03327859,-0.038259383,0.03905476,0.0774162,0.027371146,0.02777468,-0.022766344,0.057463627,-0.0418972,-0.007854604,-0.011426326,0.06060014,0.02672443,-0.0057132742,0.12320852,-0.09361747,0.0027655282,-0.014459886,0.06551424,0.05599595,-0.051249422,0.039265152,-0.0073594823,0.02990075,-0.00043339827,-0.050724316,0.09897372,0.022284199,-0.003736241,-0.04869062,-0.013430616,-0.057257283,0.021192942,-0.03175807,-0.05833408,-0.02432537,0.050603807,0.02073803,0.116175294,0.07652928,0.065651536,0.021216413,0.080380894,-0.10343465,0.0722726,0.013199145,-0.083608724,-0.034505215,0.03358511,0.0024858585,0.042271253,0.05053758,0.024498027,0.014868188,0.027680885,-0.055691,-0.07203203,-0.09379043,-0.04692487,-0.02856412,-0.048652817,0.050183266,-0.0060246564,0.06812792,0.058903612,0.04232,0.00029737008,0.046506744,0.058465447,-0.00491478,0.005301722,-0.00084302394,0.05551747,-0.08639505,-0.05664495,-0.09049268,-0.00388267,0.075404294,-0.012807495,0.018107433,-0.09428731,-0.010002944,-0.08077001,0.022596685,0.058435857,-0.03947899,0.054113153,-0.038409617,-0.00048942235,-0.040317852,0.02649518,0.078015625,-3.8305558e-08,-0.07580271,-0.036059156,0.009516553,-0.10920948,0.0031963293,0.041958887,-0.008360592,0.08068357,-0.03569411,0.024995044,-0.035516568,0.09551079,-0.053619992,0.06721604,-0.05490736,-0.019126678,-0.013179491,0.029658556,-0.0069033685,0.024778774,-0.04191972,-0.0011552246,-0.0931553,0.01984564,-0.052898258,-0.04872016,0.057292093,0.039433714,-0.0068328152,0.032664396,0.041588165,0.02090103,-0.051226784,-0.025523605,-0.104922876,-0.014288398,-0.0077941017,0.006931355,-0.106533825,0.013936801,0.04549856,-0.06337031,-0.060333528,-0.008544864,-0.05019337,-0.08220145,-0.039109968,0.043252952,-0.010727264,0.07741082,0.09742266,-0.028617417,-0.058586184,0.0038602068,-0.037175715,-0.051826645,0.040064342,0.01280972,0.029236592,-0.032560717,0.0258615,-0.026191968,0.16358471,-0.027591426 +4.2.3.206,"The enzyme, characterized from the fungi Hericium erinaceus and Cyathus africanus, requires Mg2+ for activity.",384,1.0,-0.03350417,-0.07356287,-0.05867791,0.03202427,0.062657386,-0.027898971,-0.04891689,0.035447326,-0.013681206,0.0073342775,0.03556658,-0.043186355,0.029986236,0.0143758105,-0.04676516,-0.003147781,0.054604128,0.04400766,-0.006586616,-0.03129316,0.09561115,0.024873275,0.04447489,0.0110714,0.015191545,0.033530086,0.07060892,0.0061977855,0.0033634102,-0.028689815,-0.011459955,0.0006708027,0.08078915,-0.04567671,0.015127304,0.074027024,-0.08938991,0.0013838792,0.00968406,-0.0777341,0.00030476888,-0.033625226,0.084847964,-0.047642298,-0.033676367,-0.06858543,0.0644062,-0.017430687,0.025236357,0.02530932,-0.016812073,-0.03135238,-0.07739468,-0.008586507,0.015330207,0.032126427,-0.115230985,-0.014155015,-0.065250754,-0.03793312,0.018654188,0.014169684,-0.019713137,0.027217576,-0.018584318,0.0022902745,0.027194694,-0.07257145,-0.019777104,-0.029732032,-0.034391206,-0.06298707,-0.008206927,0.0060202624,0.002974849,0.04630709,0.017770495,-0.033654876,0.07075665,0.00036046255,-0.006845324,-0.006657222,0.064134344,0.08362709,0.041156832,0.026236469,0.07511114,0.028798778,0.03440649,0.02852054,0.11926527,0.081161894,-0.027595645,0.028361969,-0.049693346,0.03654516,-0.048678707,0.040591363,-0.018407641,-0.02496258,-0.0069087925,0.055426173,-0.021084907,-0.018806387,-0.06188416,-0.016990464,-0.0098012,0.020587413,0.07707795,0.010734847,0.076688595,-0.0004888605,-0.046290465,-0.01863708,0.064728364,0.07587393,0.032559216,-0.10615226,-0.03634827,0.0027001116,0.010556871,-0.022269811,0.0031192903,0.03745451,-0.040347423,0.053707622,-0.057128415,-3.8031113e-34,-0.009851738,0.044186667,-0.0049527637,-0.017297894,-0.025300497,0.022978874,-0.042668473,0.044875287,0.016964678,-0.032705322,-0.16512759,-0.01784289,-0.01655518,0.035364956,0.0109011885,-0.0010007523,0.05516524,-0.031200338,0.13940609,0.052182455,0.050114363,0.059972454,0.001510945,0.03852277,0.0732834,0.10798654,0.07529513,-0.051280204,0.063070595,-0.00826623,0.055283736,-0.15942913,-0.07220059,0.034033325,0.07247445,0.030018983,-0.023059838,-0.0045490204,-0.029435167,0.027756521,-0.05880887,0.02406327,-0.010522948,-0.0148485955,0.040601797,-0.08446945,-0.00085724855,0.084236585,0.022114277,0.03087131,0.109720215,0.036401946,0.09997956,0.027859448,-0.06370445,0.09416395,0.0085402755,0.076491214,0.07661801,0.027910072,-0.020087373,0.049882427,0.025659215,0.08788858,0.059338283,0.056736182,-0.103271484,-0.05578579,-0.044223886,0.063660786,-0.03959226,-0.07330293,0.015763583,0.028965088,0.011902304,-0.0022774905,-0.005607951,-0.011740382,0.05848436,-0.003371421,-0.028004508,-0.027216986,0.0156699,-0.01275639,-0.06632445,-0.040570438,-0.053061213,-0.025470242,-0.012912681,0.028990084,0.057757623,0.0017882363,-0.07753053,0.063366435,0.014040164,-1.5790157e-33,0.066854455,-0.05321259,0.011053463,0.0021415101,-0.036631085,0.072652124,-0.006200432,-0.075985186,0.07712591,-0.024631863,0.0729928,-0.023808159,0.013733662,-0.06302899,-0.004946353,-0.046270125,-0.00091890345,0.13965628,-0.020495417,-0.023966657,-0.081646204,0.115486234,0.036763858,-0.059328698,0.031253044,0.01970588,0.045491096,0.027526448,0.013045125,0.042711556,0.019078298,0.07475555,-0.03239749,-0.057416577,-0.07588359,0.10555416,-0.011137449,-0.06828075,-0.0031745636,0.07329723,0.010894907,0.035146512,0.06442449,0.10643706,-0.0027610352,-0.0016068495,-0.048338864,0.07562755,-0.016695216,-0.07350475,0.03297835,-0.0013282963,-0.03822909,-0.02293128,0.07231862,0.0061747306,0.0037262903,-0.054001562,0.01968707,-0.050311297,-0.0205786,-0.041465633,0.010880097,-0.022642106,0.0074686687,0.039745312,-0.041002642,-0.0014109686,0.015014508,0.043745916,0.07243608,-0.014181385,-0.01813231,0.0436494,-0.010666501,0.10164377,-0.007747486,-0.01346799,0.057215527,-0.07317388,-0.0062213126,0.038491223,0.06384821,-0.06626294,-0.031222092,-0.14772892,0.00018147352,0.106251255,-0.0031944667,-0.007198296,-0.019011658,-0.051388714,-0.068866126,-0.0014976279,0.012753635,-2.7046921e-08,-0.043933615,-0.04984032,0.07364358,-0.11696212,0.0067565558,0.019071836,0.0071698623,-0.029849898,0.069290824,-0.03454844,-0.031651713,0.024095321,-0.048191704,-0.014603935,-0.013257314,-0.010991399,0.016914112,0.013067462,-0.0661366,-0.025923131,-0.08396204,-0.051698502,-0.13393307,-0.024533823,0.018991584,-0.103951566,-0.019636245,0.0072525246,-0.0389551,0.013331513,-0.011014121,-0.008805674,-0.008102854,-0.06231646,-0.11154454,0.03103363,-0.051585022,-0.009005705,-0.03135468,-0.0493165,-0.04366541,-0.09238748,0.04555994,-0.05056627,-0.06400352,-0.011975277,-0.0075698174,0.0047748922,-0.033085033,-0.007524837,-0.004512157,-0.081659116,-0.05179365,-0.07478011,-0.051143788,-0.012503856,0.079766765,-0.06667106,-0.05578271,-0.13980712,-0.040220186,0.013433057,0.0751458,-0.03994495 +4.2.3.207,Requires Mg2+. Characterized from the marine bacterium Saprospira grandis.,384,1.0,-0.074063994,-0.009276585,-0.018969439,0.014738703,0.029925134,-0.076010816,0.0007887375,0.044046342,-0.0063753077,0.008701643,0.040853187,-0.07403985,-0.0044203117,0.030758174,-0.007740573,-0.019240942,0.030087078,0.039131157,0.013752035,0.07392886,0.15351628,0.09187276,-0.04891527,-0.022412764,-0.0477737,0.010192848,0.0016195626,0.00011224067,0.04276858,0.012038768,-0.023191385,0.04730437,0.10447673,-0.07231076,0.06099609,0.062244467,-0.02043424,-0.057047907,0.023533007,-0.005936799,0.0032672004,-0.0033330147,0.09806328,0.002328406,0.01511625,-0.036319908,0.087561,-0.049721435,0.03215375,-0.0188174,-0.0732522,-0.026345413,-0.10194205,0.018786214,0.046670318,-0.038995426,-0.0696328,-0.054020036,-0.022635922,-0.032884967,0.021501882,0.021389607,-0.0095871,-0.025164481,-0.015089552,0.0067963414,0.017318998,-0.09985152,0.019445099,0.012645798,-0.03302634,-0.0026844891,-0.043847386,0.04331424,-0.10051379,0.09173085,0.048509076,-0.038827527,0.053217318,0.0022018494,-0.03202181,0.009719792,0.037818745,0.0790504,0.013744638,-0.041519843,0.087337025,0.059264515,0.002434139,0.087605886,0.045453724,0.025238544,0.030636257,-0.016298,-0.053377952,0.041231222,-0.045547146,-0.029562753,0.034279022,-0.0053775543,-0.050789554,0.03281288,0.031384353,-0.04027441,-0.106851764,-0.05100924,0.007372113,0.0807173,0.034255784,0.018697506,0.030679017,0.005356733,-0.03956485,0.049085595,0.006934689,0.06698462,0.025201334,-0.10419924,-0.038447928,0.0022570824,0.020446427,-0.03630983,-0.001891494,0.028301992,-0.020056976,0.013416761,-0.02654741,-7.139186e-34,0.01583908,-0.016415194,0.034435607,0.006476479,-0.02593095,0.004296112,-0.09847065,-0.105684154,0.0057616374,0.0014324143,-0.13624035,-0.017138757,-0.02189893,0.09311157,0.0012239629,0.024754459,-0.014288357,-0.020769143,0.08939822,-0.0014798002,-0.0029202576,0.04874934,0.03846095,-0.10681433,0.07052912,0.11148282,0.0494999,-0.13590649,0.05832156,0.021519864,0.08994899,-0.17050833,-0.041464664,0.05544283,0.09058657,0.02963579,-0.04984571,-0.04521529,-0.045315824,0.006683015,-0.04135355,0.08161915,-0.02650922,0.058044106,0.091634095,-0.08436063,-0.009009386,0.04597789,0.03688285,0.050893366,0.012155535,0.03232271,0.0046651694,0.055851605,-0.06886718,0.039958026,0.023913372,0.05398094,-0.006662383,-0.008799767,0.016066372,0.042587277,0.023777217,0.061106697,0.1431689,0.0788106,-0.09888968,-0.020657334,-0.009468993,0.03243654,-0.019587466,-0.13112573,0.050342638,0.023578154,-0.04726532,-0.012113383,0.037356064,0.007100453,0.007536762,0.057699036,-0.096833624,-0.006454823,0.010413934,-0.04818799,-0.10758503,0.048885547,-0.035566527,0.0030984473,0.0013975783,0.036667965,0.055304453,-0.030790968,-0.068910986,0.027483929,-0.036532175,-1.2944788e-33,0.028006664,0.0048263366,0.05554589,-0.021470444,-0.03776798,0.026287258,-0.034229588,-0.08533562,-0.022832138,-0.005145572,0.049155824,0.047620174,-0.0033169473,-0.03701542,0.0136209335,-0.060197417,0.01308214,0.05937008,-0.061563276,-0.05615781,0.047748994,0.091812424,0.05075694,-0.0076699504,0.04964739,0.0052844933,-3.2043507e-05,0.047888994,-0.05069774,0.0111831995,0.02464948,0.09534834,-0.049743466,-0.11007492,-0.046994686,-0.00055776216,0.0016299908,-0.0025901208,-0.034486506,0.052275665,0.021984452,0.0370662,0.06802065,0.06666538,-0.024900006,0.05455794,0.035496943,-0.006691675,0.07796165,-0.032335754,-0.029891826,-0.032811213,-0.052667804,-0.05042657,0.069301166,-0.020272395,-0.032654546,0.032960773,-0.006408964,-0.05753235,0.044331647,-0.061487112,0.04885445,-0.09142413,0.005781274,0.08126152,0.074733645,0.02094281,-0.013306902,0.043558106,0.055275783,0.029079752,0.013664797,0.013614658,-0.022080405,0.05406266,-0.12031805,-0.040696573,0.0419448,-0.069631346,0.020143097,0.057934355,-0.04169905,-0.0111041665,0.040920164,-0.10271364,-0.012851298,0.055724427,-0.0098049315,-0.017912827,-0.07767704,-0.04678113,-0.059175704,0.015612276,-0.013034739,-2.241155e-08,-0.031086175,-0.028711895,0.010266451,-0.022833426,-0.032106165,0.06937239,-0.113138825,0.031113645,0.050817855,-0.06298098,0.061477102,0.008472879,0.0012881935,-0.03791855,0.013295828,-0.009939473,0.013755576,-0.04541397,-0.045022894,-0.0726703,-0.02230339,-0.07400773,-0.106810525,0.049286384,0.016583677,-0.088723555,0.0073917457,0.05361798,-0.008655848,-0.05279501,0.037245885,0.007521371,-0.036469817,-0.0042654085,-0.05769952,0.025814762,-0.09148859,-0.020949913,-0.003886544,-0.059958488,-0.011147386,0.03489586,0.025719754,0.008871227,-0.058188573,0.0598769,0.0017552573,0.05928308,-0.10284734,0.015965885,0.049572516,-0.06043549,-0.018663757,0.025061253,-0.07728811,0.018420756,0.07009856,-0.02430805,-0.06131748,-0.028752748,0.024910541,-0.027851658,0.03946428,-0.022268299 +4.2.3.208,Requires Mg2+. Characterized from the bacterium Chloroflexus aurantiacus.,384,0.9999999,-0.09524875,-0.02300013,-0.0076181297,0.016102973,0.019451438,-0.052393947,0.058529988,0.005285464,-0.015308763,0.0013657784,0.0022538882,-0.10393078,0.07334022,0.056035023,-0.046800837,-0.036919944,0.024415817,0.027460441,0.013737159,0.053753536,0.11820559,0.059992343,-0.02757133,-0.033584353,-0.030661728,0.063533135,0.036197737,-0.06039233,0.06304568,-0.006158787,-0.007975341,0.06958282,0.11645258,-0.12691951,0.07579197,0.06808225,-0.03586329,-0.057847477,0.039436925,-0.011358363,-0.037671663,0.038223412,0.06548832,0.023010144,0.0028241477,-0.020916255,0.10086823,-0.052588515,0.06566277,0.03864717,-0.02468026,0.022371046,-0.09248751,0.009551202,0.016521646,-0.013489026,-0.12040712,-0.016092064,0.028737247,-0.047151018,-0.030576289,-0.0007230978,-0.0021781297,0.03284988,0.02431934,-0.0060908743,0.006870122,-0.080691196,0.01991383,-0.019311907,0.009535751,0.0040487866,-0.050450306,0.02699877,-0.029023161,0.07093039,0.08210874,-0.09478532,0.020873995,-0.014892804,-0.036737993,0.018091096,0.064181626,0.09798818,0.04540244,-0.018569782,0.0959146,0.008810313,-0.0326242,0.0672728,0.07752326,0.055434875,0.028130662,-0.015451077,-0.03212972,0.056059193,-0.059222236,-0.014897146,0.027391454,-0.012464505,-0.048183024,0.018357154,-0.004859946,0.010267935,-0.04930158,-0.05185692,-0.057044066,0.033248633,0.03923122,0.025330842,0.06409246,0.0033500772,-0.05126924,0.0015190695,0.0795801,0.03236082,0.046993602,-0.10245005,-0.03481232,0.0025564954,0.018120628,-0.05843487,-0.049080454,-0.003883687,-0.062820345,0.059340246,-0.039655086,1.8128444e-33,-0.05035147,-0.030956306,0.09711558,0.007118377,-0.06742084,-0.0051342095,-0.09030961,-0.05738711,-0.0077554598,-0.072165936,-0.067998394,-0.03735191,-0.019785272,0.029191045,-0.014248772,-0.028279044,-0.046769977,-0.007447728,0.09773465,0.035981905,-0.053674847,0.11972805,0.037821963,-0.028152632,0.049247347,0.06663064,0.054551702,-0.09351275,0.09599875,0.0048544966,0.0907537,-0.12736283,-0.035540763,0.038567208,0.010860043,0.06916541,-0.03420537,-0.054664776,-0.029883254,0.007843447,-0.07140802,0.043714978,-0.04745226,0.04215014,0.08395616,-0.10612138,-0.014652004,0.0014770624,-0.02088277,0.064862534,-0.0063791065,0.059491187,0.056515735,0.010667584,-0.06528781,0.050501782,0.016338488,0.037075285,0.025304142,0.025095325,0.026259683,0.09739,0.008547007,0.054513734,0.11060891,0.024088107,-0.11752623,-0.06657607,-0.004907937,-0.008208987,-0.04970002,-0.10264995,0.031153148,0.01062954,0.018692894,-0.04025864,0.029722247,0.008283645,0.012691747,-0.004223621,-0.056810543,-0.013314665,0.07658372,-0.029259987,-0.09664567,0.004484558,-0.021067778,-0.028014753,-0.01902851,0.03934106,0.10298114,-0.03342634,-0.07986071,0.033239763,-0.0698372,-2.5601435e-33,0.056455683,-0.052581582,0.039721757,0.015257291,-0.06386717,0.042414885,-0.035095405,-0.08185411,-0.029757129,0.0005664185,0.08262121,0.04780823,-0.049971856,-0.0582437,0.022427486,-0.05006415,0.047768027,0.09272529,-0.0722645,-0.01762897,0.009042342,0.087657526,0.057190318,-0.0029312384,0.0030294398,0.048579253,-0.01159976,0.01074026,0.030861044,0.009972974,-0.020388227,0.08696437,-0.056417882,-0.033233255,-0.021926366,-0.047450766,0.03352636,-0.025842465,-0.0532909,0.05150179,-0.017580777,0.06547914,0.066539906,0.047173582,0.014009669,0.04241035,0.047226276,-0.0021399425,0.02207029,-0.048597377,0.002120698,-0.030392209,-0.08060214,-0.03002023,0.049772013,-0.038430903,-0.012463855,0.04918487,0.099204,-0.04910298,0.020326357,-0.026800206,0.05769986,-0.087563954,0.048152164,0.06865399,0.02214195,0.078658946,-0.001600042,0.021885656,0.06557674,0.038109254,0.053639863,-0.02594584,-0.021251056,0.069322094,-0.035875417,-0.05373119,0.0401111,-0.059667725,-0.024163535,0.051941972,-0.021501964,0.024863837,0.03588507,-0.12776907,-0.027505375,-0.011806888,-0.0027447995,0.009168485,-0.09418611,-0.048549943,-0.007369627,0.0043378184,0.020720728,-2.498198e-08,-0.035315357,-0.04118129,0.012732205,-0.06631944,0.04279699,0.055487856,-0.058768947,-0.044500627,0.07302307,-0.040582344,0.067641735,-0.026779825,0.028915126,-0.01257684,-0.013571535,0.038736813,-0.006818573,-0.06473972,-0.024346113,-0.03527522,-0.08675307,-0.05108679,-0.12527587,0.07489036,0.032434285,-0.07692609,0.026143279,0.03296798,0.005798053,-0.010774585,-0.01048477,-0.018014116,-0.0378533,-0.055426445,-0.03830075,0.011369262,-0.057697278,-0.0074047092,-0.013856522,-0.039552957,-0.03682163,0.03239616,0.031277414,0.007628386,0.0022699998,0.015530203,0.0061381217,0.052011997,-0.09607938,-0.013145934,0.01852927,-0.05923107,-0.04194563,-0.024481818,-0.094786294,-0.0071574,0.072441936,-0.10203105,-0.029624712,-0.06670601,0.022094049,0.008010371,0.06229576,0.025630904 +4.2.3.209,Requires Mg2+. Characterized from the bacterium Archangium violaceum.,384,0.99999994,-0.056018714,-0.018188445,0.009648049,0.022258345,0.023356985,-0.07035084,-0.036244385,0.037492834,-0.005988578,0.011689975,0.004524216,-0.069457464,-0.0035659722,0.024695229,-0.042480573,-0.021083726,0.061654355,0.05346291,0.016242608,0.058744323,0.12081676,0.08403394,0.017660735,-0.0449224,-0.047923047,0.058585323,0.032094248,0.00053910335,0.08755402,-0.039672483,-0.01708354,0.011527447,0.10576188,-0.12327985,0.04927423,0.084180795,-0.054178018,-0.037522312,0.007972319,-0.025129952,0.03484357,0.009533942,0.13429797,-0.025408566,0.021860255,-0.04481171,0.07113728,-0.045352146,0.028942987,0.032236986,-0.049939733,-0.032199014,-0.10396328,0.019583926,0.015057992,0.0016720026,-0.07147687,-0.051876813,-0.0072778845,-0.020291083,0.024597134,0.03375345,-0.020464234,-0.016973922,0.009848768,0.02861996,0.01469061,-0.09615265,0.028833127,0.0375058,-0.011012809,-0.018321967,-0.031910613,0.06166913,-0.0920724,0.07885152,0.048894856,-0.060246024,0.101262726,-0.02715727,-0.03379604,0.0045103603,0.049077943,0.04763067,0.016413264,0.013065135,0.08023832,0.046586998,-0.016786376,0.061391715,0.07230604,0.030013788,0.032332424,-0.027380118,-0.026841322,0.06894204,-0.019968027,-0.005408599,0.0028616402,-0.0009218872,-0.039617892,0.054207996,0.020681854,-0.04801444,-0.10570287,-0.07449535,-0.046579156,0.07270897,0.05426485,0.04573951,0.0641805,0.002222593,-0.021939103,-0.001600577,0.027835388,0.02873645,0.022468988,-0.10666419,-0.028393602,0.015026441,-0.0005681232,-0.056781944,0.016483257,-0.02016533,-0.025932385,-0.011901316,-0.064589754,-4.443244e-34,0.01745283,-0.0765876,0.055587195,0.0051331553,-0.059689995,0.036725704,-0.06785501,-0.08238578,-0.0065380437,-0.02830605,-0.12280961,-0.050755013,-0.0029949276,0.025697127,0.013343088,0.02295308,-0.026251609,-0.0050045885,0.06027646,0.0012739929,-0.0048179035,0.08345521,-0.009945871,-0.028677212,0.03989443,0.07510218,0.065822765,-0.12252262,0.010048533,0.01685134,0.073563315,-0.09850255,-0.07926321,0.043264296,0.06664979,0.021754263,-0.034997012,-0.045776878,-0.034484416,0.003070426,0.0070157163,0.053932145,-0.038771983,0.04129063,0.096082024,-0.08172863,0.0046944316,0.045084104,0.0273435,0.063171044,0.0123154465,0.07343544,0.042349238,0.035360325,-0.07875871,0.04270447,0.025366139,0.073032156,0.035747103,0.0018343054,-0.01781663,0.07148621,0.017373929,0.10172892,0.079923004,0.0363366,-0.12591888,-0.0336363,-0.006733813,-0.0005825472,0.0026628315,-0.124390736,0.011076045,0.016721586,-0.08318889,-0.02119829,-0.0029550816,0.0018108593,0.036087256,0.0012980772,-0.08546873,-0.030091777,0.016313732,-0.048413813,-0.09171394,0.021918671,-0.023522908,-0.013323688,-0.010105998,0.039883073,0.11021957,0.0026320936,-0.12204262,0.08075238,-0.021310197,-1.190303e-33,0.062421136,-0.01123141,0.03596612,0.00462067,-0.052742705,0.058609203,0.015202124,-0.08700972,-0.026538102,-0.012826283,0.07068969,0.07300614,-0.0021504045,-0.06029149,0.004570198,-0.060687024,0.034951776,0.034125544,-0.024200063,-0.035460383,0.035531737,0.10381356,0.023003455,-0.01919081,0.024328161,0.043112632,0.0136852665,-0.010807766,-0.0257688,0.039415784,0.024945917,0.10271932,-0.03892971,-0.051527448,-0.052133363,-0.052061785,0.049253445,-0.05159979,-0.060934138,0.009202352,0.0028835428,0.10946753,0.032237437,0.08897367,0.025052037,0.018833466,0.038046435,-0.0018465308,0.038127627,-0.05757596,-0.0050281654,-0.07971435,-0.033495907,-0.036074847,0.021561429,-0.030187517,-0.027226161,0.019954463,0.030738298,-0.0046019047,-0.012827587,-0.029096814,0.07532111,-0.09604196,0.041362345,0.09823298,0.082903616,0.07838379,-0.038749315,0.01006783,0.07405727,0.04734245,0.06482281,0.027310228,0.016221695,0.069783814,-0.01784835,-0.03360851,0.022158751,-0.10627371,0.006418856,0.031874392,-0.019307328,-0.008264966,0.013064712,-0.12203378,-0.01287622,0.06011346,-0.0288221,0.024141748,-0.08469145,-0.054034736,-0.081551075,0.008964472,0.049840216,-2.250396e-08,-0.07026713,-0.0042129587,0.012626652,-0.05977881,0.004256717,0.04103638,-0.058197588,0.012374328,0.08826948,-0.07097084,0.030257842,-0.006533223,-0.011250511,0.05587245,0.017208742,0.022142516,0.0010406674,-0.053555377,-0.07590208,-0.0862592,-0.06708917,-0.09037618,-0.023723615,0.03473553,0.0065803425,-0.059767473,-0.002130459,0.03570925,-0.014642415,-0.025548136,-0.001531726,-0.0047936025,-0.016559953,-0.034328293,-0.084182166,0.069341846,-0.031663932,-0.04139381,-0.010189161,-0.050431322,-0.03171378,-0.022723494,0.04248308,-0.01189526,-0.013299206,0.034816403,-0.050919816,0.050365046,-0.10498067,-0.023946337,0.012576832,-0.06233632,-0.02299486,-0.032692693,-0.0981664,0.012070629,0.07094235,-0.04762591,-0.03290706,-0.052037004,0.082879856,-0.04517772,0.06344314,-0.023477899 +4.2.3.210,Requires Mg2+. Characterized from the bacterium Streptomyces lydicus.,384,1.0,-0.062792934,-0.036866818,-0.0625307,0.030627888,0.021488696,-0.024022719,-0.019935194,0.029569589,-0.019298384,-0.018706262,0.014255477,-0.04308012,0.074881025,0.04025559,-0.0044184565,-0.054368157,0.012806661,0.021688147,0.035606567,0.009045608,0.13384679,0.10477051,0.008138205,-0.043009624,0.013878574,0.03605674,0.0130921,-0.02325853,0.018801479,-0.008581084,0.022201203,0.019372007,0.08322902,-0.11786002,0.1031406,0.10221472,-0.054894444,-0.0282478,0.041056912,-0.009225992,-0.003618311,-0.0021490336,0.113406554,0.052260187,-0.025714682,0.00016765135,0.09063894,0.0160028,0.013707337,0.010422073,-0.05913859,-0.030780327,-0.09342883,0.01686325,0.044131104,0.007288826,-0.10138061,0.011894739,-0.023950337,-0.053538088,0.00045331926,-0.0027095852,-0.018427754,-0.022178119,-0.009128396,0.008485993,0.020484263,-0.1184539,0.0668261,0.030224496,-0.037190285,-0.014542452,-0.028020669,0.062408816,-0.043767575,0.044611048,0.033604354,-0.0755746,0.030622704,0.03089213,0.0016008399,-0.008708771,0.044478137,0.07704614,0.037888486,-0.056477796,0.06496298,0.055053145,-0.015972039,0.0678805,0.1060502,0.017820023,-0.013564855,0.008799035,-0.04891863,0.025979433,-0.067709446,-0.028948182,0.013332036,-0.0013307781,-0.053287514,0.037698813,0.013460436,0.037952345,-0.037811693,-0.042586796,-0.059940904,0.031095615,0.017523594,-0.007049184,0.096785076,0.02625782,-0.02666616,0.0013893371,0.072812945,0.015147925,0.056918085,-0.11415881,-0.043875184,-0.024429344,0.004060717,0.011658996,0.005341628,0.00031496194,-0.04349515,0.0068157357,-0.07544685,3.2351905e-34,-0.05980804,-0.010981344,0.09567137,0.009275629,-0.035475437,0.008534618,-0.08731996,-0.050974775,0.044761147,-0.037019223,-0.09002177,-0.081787504,-0.0064224387,0.07392485,0.015696015,-0.010225544,-0.018958649,0.04486078,0.118161924,0.018049134,-0.015732434,0.059910018,0.038647827,-0.026214655,0.04856299,0.11209022,0.064638406,-0.08303823,0.09811766,0.0005029665,0.07900368,-0.14656457,-0.03792424,0.033742685,0.031532194,-0.000615259,-0.07390051,-0.06797251,0.040897127,-0.0022089488,-0.05011817,0.05705333,-0.011663919,0.0429856,0.0694152,-0.0741498,0.00029573526,0.026044799,-0.02108469,0.07681158,0.063556045,0.015511814,0.061927214,0.014330155,-0.10433381,0.032467786,0.013298707,0.07800668,0.034147218,0.017306603,0.013456456,0.078441344,0.04763065,0.05673031,0.116414644,0.032460082,-0.09809463,-0.034499027,-0.018287338,0.044066805,-0.02510643,-0.11243817,0.05819859,-0.0077044223,-0.026036724,-0.0153995035,-0.032009967,0.0156030925,0.05212057,0.029467715,-0.07335207,-0.023990897,-0.00924732,-0.063130945,-0.106960766,0.026986707,-0.022242574,-0.07195415,0.03815749,0.055110957,0.019682907,-0.022758298,-0.073393345,0.0693845,0.0043225917,-1.936807e-33,0.05350642,-0.02557569,0.07368573,0.016303647,-0.07425977,0.026292076,-0.01977642,-0.09545949,-0.004529327,-0.005045114,0.07727475,0.02736936,-0.03629761,-0.062521785,0.015508909,-0.067473926,0.004613811,0.07654779,-0.046779014,0.0046742684,0.02873639,0.09879227,0.016840842,-0.010432232,0.05070244,0.026949272,0.0075784884,0.023136256,0.019071369,0.05199646,0.026260259,0.062114023,-0.06728366,-0.08233428,-0.06727951,0.03200904,0.0029976221,-0.009778967,0.00024645764,0.03232709,0.075437315,0.075351015,0.072539054,0.09705143,-0.0038493397,0.037203964,0.028772159,0.036962315,0.06748734,-0.055874806,-0.04175055,-0.009791222,-0.09779909,-0.054702856,0.016601976,-0.01487188,-0.04498667,-0.00018236501,0.0076644504,-0.05687545,-0.0059134583,-0.052227534,0.016278159,-0.069891624,0.037842143,0.022078361,0.02535959,0.039309196,0.06255716,0.03251533,0.053490356,0.034225002,0.04409165,-0.0007469274,-0.021149319,0.083378755,-0.07892862,-0.027154103,0.02413802,-0.059223376,0.013184834,0.013841639,-0.008730574,0.00361775,0.051338,-0.13188492,-0.025569234,0.02728896,-0.006944408,0.011074044,-0.07771566,-0.053292014,-0.032554075,0.02157769,-0.017907374,-2.2556282e-08,-0.03102981,-0.059720326,0.06440191,-0.064988956,0.014194449,0.030299226,-0.090491034,-0.03841111,0.06945234,-0.027959585,0.025787266,-0.054355912,-0.022599021,-0.034767427,-0.030444989,0.019208804,-0.060055327,-0.043330606,-0.04064303,-0.06649298,-0.096348934,-0.083571285,-0.10074438,0.069248535,0.02951907,-0.06372645,-0.004896444,0.045803003,-0.0011665788,-0.00023994014,0.050035585,-0.031570423,-0.0387841,-0.012596166,-0.06101139,-0.012107892,-0.055388365,-0.016129564,0.004466719,-0.050562106,-0.033682812,0.020043176,0.015176875,0.032858707,-0.09190885,0.0330188,-0.04123527,0.032050017,-0.119069315,-0.005239597,0.03674566,-0.0589151,-0.0310605,0.017530067,-0.071558185,0.032967813,0.04931398,-0.051633544,-0.052439895,-0.05244522,0.015842564,0.00036229784,0.089535356,-0.053638406 +4.2.3.211,"The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin.",384,0.99999994,-0.013194714,0.08426623,-0.15314691,0.0042583155,0.07669596,0.03556399,-0.12359502,0.07957563,0.07033358,-0.07844282,0.020286579,-0.07060971,-0.10150141,-0.007963656,-0.07340262,0.028289419,-0.040555183,0.064648956,-0.028512748,-0.053716686,0.101600006,0.05106454,-0.026595494,0.041529473,-0.006145743,-0.010954082,0.027407868,-0.023559542,-0.04815272,-0.056179382,-0.07455112,-0.038660422,0.071874835,0.0003855455,0.064187,0.10615383,-0.037358988,-0.035061527,0.069723144,-0.042720538,0.023476737,-0.07910763,-0.05791432,-0.031875964,-0.08408508,0.0085929725,0.009872482,0.062404007,0.030728752,0.049025647,-0.08893177,0.014458112,-0.004192725,-0.035360016,0.011298559,0.08031752,0.042603727,-0.0849133,-0.047438677,0.014181911,-0.009345995,0.014362042,0.009788982,-0.0021436845,-0.012857222,-0.05748513,-0.008065521,-0.050944522,-0.042621642,-0.05288711,-0.025129735,-0.037646722,0.04544057,-0.02848791,0.07198101,0.061894197,-0.010602163,-0.021630632,0.060060214,-0.00075984985,0.08746071,0.035053134,0.012662932,0.043981526,0.060426258,-0.05436344,0.014854284,0.016819231,0.051809166,0.07931996,0.018508863,-5.4095144e-05,-0.0026981663,-0.025029942,0.0056785084,0.0741202,0.05955696,0.03742544,0.031273216,-0.03264231,-0.005789022,0.006435523,0.012274485,-0.087937675,0.053314455,-0.015985856,-0.010633863,0.077307,0.061578937,-0.04259365,0.006449544,-0.055717565,0.07184141,-0.03588154,0.026697587,0.028487522,0.002905563,0.014431176,-0.042470478,0.036238264,0.04900379,0.03865447,0.053950977,0.0505779,-0.0020660344,0.040224425,-0.08501737,2.921367e-34,0.07899072,0.06118661,-0.05065336,0.021782603,0.019982843,-0.05368414,-0.020136911,0.0011796212,-0.056300323,-0.032745205,-0.096168436,-0.09118066,-0.082439974,0.03850966,-0.047844224,-0.025014315,0.028061908,-0.0062111667,-0.007261626,-0.010952813,0.024629543,0.024404326,-0.06785587,0.0161112,-0.016705807,0.07697225,-0.03367229,0.046467733,0.0022913876,-0.01585136,0.028222775,-0.06846569,-0.084395476,-0.025757568,0.10964587,0.029215872,-0.018532401,-0.034122422,-0.11031776,-0.014042738,-0.0011401016,0.03356952,-0.029594058,-0.08751778,0.02255427,-0.0074781086,-0.025816707,0.063695975,0.05016104,0.021416975,0.03406206,-0.015046354,0.11678528,0.0119791,0.011868517,-0.031523254,-0.025433455,0.010365353,0.0033627257,0.033687185,-0.06357239,0.023398232,-0.033468574,0.06341209,-0.00013626806,-0.007510969,-0.033089597,-0.022078227,0.011412262,0.033896275,-0.004312672,-0.017055033,-0.060024675,0.012016005,0.021078175,-0.026654081,-0.060500335,-0.025476018,0.0068230764,-0.022361929,-0.0104276035,0.041137278,-0.014559241,-0.08195347,-0.10942759,0.020204281,-0.0011303452,-0.045790046,-0.006901632,0.007936213,-0.049488604,-0.11450745,-0.035627153,0.035954222,0.06067996,-2.7169813e-33,0.011908876,-0.11799963,0.040389158,-0.012682059,-0.08597928,0.073317245,-0.031057633,-0.012339876,-0.057074744,-0.026997622,0.011684597,-0.068767175,0.046448827,-0.016640985,-0.01981951,0.047287215,0.07018786,0.049890723,0.02861646,0.0010323155,-0.038200855,0.1108314,0.039108455,0.020786578,0.068748154,0.004106989,6.112532e-05,0.029025234,0.011134886,0.043600272,-0.038738776,0.08694697,0.0024286243,0.024181359,-0.069179155,0.05318679,-0.055541992,0.017154392,0.088298924,0.04570783,0.005057733,0.0030629986,0.027955752,0.08514548,0.0112698395,0.09200643,-0.015938403,0.016183121,0.01647599,-0.038993176,0.0031284837,0.023495669,-0.014775316,0.014077647,0.0013078195,0.013621817,0.0075542117,-0.040901996,0.007206568,-0.024626931,-0.06295023,-0.06513362,0.0022957735,-0.020437043,0.054072555,0.027987653,-0.053097542,-0.0042795837,0.11631746,-0.033395804,0.124982975,0.049853094,0.015860587,0.076293685,-0.0077193924,-0.057251547,-0.037542976,0.018616807,-0.014846743,-0.0123153385,-0.028940152,-0.013785874,0.0586092,-0.042583,-0.07973923,-0.12238668,0.13717242,0.06517082,-0.09125479,0.046054292,-0.051585976,0.025974264,-0.07514338,0.07702949,0.049616285,-2.7798583e-08,0.025292229,-0.02057209,0.052370735,-0.09667305,-0.0063217236,0.008979885,0.024694826,0.0140941255,0.028320601,0.007551902,-0.10673791,0.049614727,0.00364408,0.022580035,0.040623132,-0.011087783,-0.021070292,0.04272365,0.012201054,0.02062667,-0.022364201,0.0012351085,-0.11948355,0.031705163,0.0008248227,-0.063073196,0.018797267,-0.024258059,0.024961477,0.032289293,-0.027000131,0.06705008,-0.0070264027,-0.060738467,-0.08489591,0.048794392,-0.047907818,-0.1026034,-0.028465552,0.008949056,0.042177543,-0.0133862,-0.049768195,-0.038066506,-0.10661356,-0.027015176,0.0403356,0.05989684,-0.04492113,0.009675358,0.037848834,-0.019372405,0.00974855,-0.030477524,-0.08614668,-0.014526125,0.10744375,-0.016589653,-0.018667527,-0.015238376,-0.015732385,0.009561209,0.19888431,-0.08359069 +4.3.3.8,"A pyridoxal 5'-phosphate protein. The enzyme degrades the toxic amino acid L-mimosine. It cleaves a carbon-nitrogen bond, releasing 3-hydroxy-4H-pyrid-4-one and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. It is thought to have evolved from EC 4.4.1.13, cysteine-S-conjugate beta-lyase. It has been described in both mimosine-producing plants and some bacteria.",384,1.0,-0.06964667,-0.073339485,0.00021635782,-0.05669275,0.10788499,0.03231174,0.025125321,0.08051853,0.06021509,0.07880602,0.06052582,0.0046248036,-0.056429006,0.10364004,-0.09801574,0.08338543,-0.0642829,-0.016600063,-0.009979878,-0.012213204,0.07856948,0.05492259,-0.054251734,0.035632946,-0.014947397,0.047156077,0.040232744,0.03553396,-0.030610891,-0.06313243,-0.049999002,-0.022487324,0.07664526,-0.12350894,0.06439643,0.11543198,-0.008113507,-0.08288457,0.079589896,0.006243355,-0.041045588,-0.0138541125,0.013623712,0.0065376973,-0.07233746,0.018401459,0.083697766,0.0130741345,0.060630433,-0.04798657,-0.06881722,-0.05840421,-0.0059517445,-0.0008061438,-0.029570157,-0.036683753,-0.08825032,0.052508898,-0.06174773,0.006816197,0.032045443,0.03941712,-0.0064474405,-0.011880361,-0.015497324,-0.0046135867,0.00012371049,-0.060905263,-0.0014828715,-0.023679687,-0.02519838,-0.09012054,0.060718194,-0.0050886055,-0.022225343,0.10027744,0.0015898148,-0.012850202,-0.008490721,-0.026507346,0.01866822,0.010726516,-0.004638639,-0.038983054,0.043145575,-0.016200943,-0.02127651,0.0297868,0.06958685,0.0068858643,0.015529902,0.062311295,0.013283459,0.024970677,-0.021396115,0.069259994,0.024871996,0.0060280175,0.010456322,-0.02310201,-0.004862694,0.07667828,-0.06317574,-0.028737731,-0.014706156,-0.024524374,0.013816793,0.06922223,-0.021963902,-0.056253597,-0.039492164,0.023047619,-0.021939004,0.02924408,-0.019468896,0.03922004,0.05758056,0.033054706,-0.05965583,0.027587917,0.039449193,-0.032862604,-0.002063199,0.09155354,-0.08752887,0.04196689,-0.13479449,1.13657915e-33,0.07921967,0.0093121305,0.049055308,0.044627797,-0.0006299104,-0.024944035,-0.048109207,-0.015429159,-0.022418553,-0.06580464,-0.073557936,-0.05954266,0.026578868,-0.035321917,-0.0426688,0.019032413,-0.10693164,-0.0023263376,0.10597555,0.030236527,0.007744678,0.06627958,-0.038503677,-0.0056704925,0.006065287,0.09497935,0.026706714,-0.043016557,0.008792997,-0.005332893,-0.022072116,-0.13233136,-0.09069901,-0.029917106,0.043074757,-0.037402537,-0.060241293,-0.03440242,-0.034410235,0.018865233,-0.051584616,0.02576621,0.0041421345,0.004454924,0.06404423,-0.025030041,-0.059901357,0.020813964,-0.015734158,0.009862932,0.06683589,-0.06743549,0.08202531,-0.021010011,-0.09813348,-0.017695572,-0.019559901,0.016410422,-0.004808885,0.07458696,0.040990606,0.07231033,-0.06552625,0.003938334,0.0013057847,-0.042869084,-0.04432783,-0.1018338,0.03666288,0.1190533,-0.06346636,-0.04456873,0.03790771,0.036275078,-0.00849948,-0.1156028,-0.077759616,0.034708343,-0.007191975,0.03444719,0.0277188,-0.04566087,-0.015972348,0.030883566,-0.03867132,0.020619314,0.03221259,-0.0316625,0.029141845,0.067452915,0.063162684,-0.1045854,0.008373567,0.04628438,-0.038086496,-1.0328085e-33,0.069687024,-0.06873904,0.036216516,-0.0100002345,-0.106146105,0.035397045,0.016269332,0.041281704,-0.009105904,-0.04398529,0.051624626,-0.0060622827,0.02427911,0.0006076531,-0.0032771756,-0.003364828,0.02823776,-0.0040317765,0.0142903365,-0.009313325,-0.0062596966,0.04723366,0.05186549,0.023201538,0.03376159,0.047720287,0.021810204,0.06508936,-0.003287271,0.022127723,-0.025441121,0.025280267,-0.01292747,-0.08675046,-0.033674143,0.00064443826,-0.08241475,-0.053479195,0.051145583,-0.00023811196,0.037827875,0.0732621,0.053419903,0.055430435,-0.026296666,0.07009316,-0.035659723,0.016269648,-0.015291667,-0.0021102903,0.03282543,-0.020709092,-0.062366474,-0.055280544,0.04311143,-0.04126104,-0.023665743,0.06607304,0.017973276,0.07548361,-0.002921625,-0.0929596,-0.016961789,0.047603037,0.07988388,0.08792441,0.022545448,0.054923844,0.027378961,0.054742295,0.07962474,-0.014559618,0.0070543718,0.04880053,-0.014544498,-0.015383883,-0.052501626,-0.013999972,0.03057354,-0.02641053,-0.014531034,-0.014121888,-0.004004125,-0.07532976,0.05107439,-0.121228255,0.05357171,0.1465982,0.053610023,0.035659503,0.037841905,-0.02202856,-0.027053801,0.056791767,0.11431739,-4.510771e-08,0.053288214,-0.08046396,0.014169836,0.002297655,-0.037903275,0.0062900856,0.074751146,0.032472372,0.09715252,-0.030269336,0.014997592,0.019120067,0.02591209,0.037621032,0.0032550495,0.056684226,-0.055354316,0.03669342,0.0059819,0.024436858,-0.088431425,0.0025811696,-0.13038352,0.008941892,0.021265844,-0.041710567,0.031203631,0.051766336,0.011341559,-0.04959495,0.034124993,0.010811389,0.03800107,-0.025382921,-0.11982891,0.008075664,-0.10586327,-0.023482258,-0.04438352,-0.004013626,-0.054423347,0.02406905,-0.05803344,-0.020807052,0.021246018,0.018134566,-0.048600443,0.03991726,0.00041174117,0.018083502,0.06676039,-0.04149501,0.030497352,-0.10481255,-0.11438482,-0.031287897,0.0522488,-0.007600072,0.015436635,-0.1150969,-0.021873927,-0.013128109,0.12318446,-0.014340999 +4.4.1.42,"The enzyme was originally described from the yeast Saccharomyces cerevisiae (as EC 2.5.1.4), though it had not been well characterized. It was also incorrectly described from several bacteriophages as a hydrolase (EC 3.13.2.2). Later work has shown the bacteriophage enzyme to be a lyase. The enzyme binds its substrate at the border between two subunits of a trimeric complex in a position that prevents it from interacting with water. Instead, the substrate reacts with itself and splits in two. The product, L-homoserine lactone, spontaneously hydrolyses to L-homoserine.",384,1.0,-0.0482776,-0.07284166,-0.027050573,-0.018943798,0.03782293,0.05856503,-0.07402226,0.06844547,0.0007515617,0.012220448,0.0013043529,-0.018073998,-0.041913718,0.062252786,-0.032488022,0.026846305,-0.14390719,0.012391145,-0.019629614,-0.065110885,0.110247366,0.08701862,-0.066710934,0.035810277,0.06515576,-0.027711513,0.080847,-0.020348972,-0.025677858,-0.05632989,0.011270741,-0.10920094,0.07794826,-0.042597294,0.007106311,0.048338935,0.05106927,-0.06623595,0.09086152,0.0033905122,-0.010762108,-0.01553884,-0.028516263,-0.004127459,-0.06704667,0.037196502,0.030531691,0.029740395,0.029328613,-0.02107568,-0.07312718,-0.068972506,0.0166424,0.02151873,-0.074712075,0.02266029,-0.032724857,-0.02398585,0.042788096,0.021958197,-0.043847885,0.030468503,0.032694947,0.04597979,-0.012668023,-0.10989486,0.026284419,-0.057526194,0.0229579,-0.042463947,-0.05585873,-0.10504608,-0.033108525,0.049618233,0.016533133,0.0023335845,0.028296595,-0.057969034,0.00594901,0.039583124,0.031787567,-0.08339359,-0.018223075,0.14251402,-0.016020507,-0.04590702,0.027581286,0.05000332,0.09963839,-0.013704379,-0.034885142,-0.018724851,-0.05110766,-0.03703669,-0.045341574,0.043657854,-0.0062660323,0.042302806,0.034502026,-0.0333111,-0.033426955,0.0047167083,0.043778706,-0.035359774,0.030386291,0.014153573,0.046034303,0.094499566,0.078973785,-0.009391687,0.04492247,-0.0111529445,0.012658893,0.019679481,-0.034398917,0.020161163,0.05269932,-0.03513066,-0.034018997,-0.007349498,0.050067168,-0.029991567,0.023015097,-0.001016635,-0.070819035,0.0882535,-0.07654453,3.6232368e-34,0.06405261,-0.026621018,-0.023439283,-0.017051445,0.013671528,-0.048196442,-0.11460808,0.020330222,-0.07647358,-0.030285425,0.024818446,-0.0478,-0.007256343,0.07294414,-0.0469889,-0.06077723,0.006108557,-0.015340341,0.028627027,0.030489972,-0.034473237,0.063608676,-0.04184841,0.05654684,0.07603845,0.010278915,0.048348904,-0.018601043,0.09804889,0.0009961786,-0.0051309816,-0.07217108,-0.062182937,0.012200335,0.07455934,0.015225286,-0.014318428,-0.03531896,-0.01681097,0.029351378,0.031130593,0.01835924,0.004760571,-0.046779603,0.015064942,-0.019571124,-0.042309042,0.09133494,0.04875406,0.07398224,0.04646533,-0.03890688,0.07280643,0.0113138165,-0.04897775,0.022815391,-0.0405106,0.06406156,0.09391561,0.0338954,-0.008838029,0.08516886,0.019683981,0.08190754,0.053860154,0.013213746,-0.012208424,-0.066894345,0.046995204,0.053881865,-0.08654079,0.014021466,0.030741887,-0.009789019,0.036942933,-0.054416303,-0.056411415,-0.0674112,-0.014643337,0.022647128,0.027341083,-0.05883063,0.017809188,0.008640908,-0.069559276,-0.020233136,-0.05990718,0.015498946,-0.03682369,-0.059100803,0.009546734,-0.051140323,0.015481707,0.08265829,0.005911577,-3.2650818e-33,0.076748714,-0.1407865,0.0860335,-0.019656237,-0.040637627,0.061459936,0.039680604,0.04538768,-0.039008193,-0.02450622,0.07305635,-0.015369933,-0.029783022,-0.010938813,-0.025936767,0.015681067,0.028884627,-0.00158995,-0.003868353,0.009193206,0.028604042,0.09265329,0.0069222646,0.03846064,0.110046536,-0.015461128,0.032775503,0.06708567,-0.034429185,0.006776851,-0.03392783,-0.0031016024,0.049398508,-0.12869108,-0.054750845,0.085032366,-0.040056404,0.0062652812,0.027902909,-0.004015294,0.0027031517,-0.0033211382,0.036402,0.028394083,-0.016607884,0.088962615,-0.0044484246,0.058074642,0.03806906,-0.027621139,-0.06274183,-0.011930008,0.007492857,-0.001680542,-0.018706938,0.014719811,-0.01288884,0.034672316,-0.02237719,-0.058773495,-0.005814799,-0.06397799,0.030333564,0.027502915,0.004161564,0.053565223,-0.058079734,-0.026766116,0.01870826,-0.08083507,0.0601967,-0.013925922,0.06155832,0.063317284,0.004145823,-0.007872667,-0.09556178,-0.13715746,-0.03352266,-0.009315118,0.044502582,-0.016647628,-0.012138101,-0.024548765,0.04953493,-0.091934904,-0.037032835,0.07257269,-0.026709149,0.018840661,-0.00982317,-0.049462173,-0.10206444,0.06130346,0.038886037,-4.6734193e-08,0.0705675,-0.047935594,0.04242854,-0.06744526,-0.0018096307,0.02902362,0.053361338,-0.016477587,0.04840974,-0.032343525,-0.08577546,0.031502854,-0.03785248,0.034098264,0.05580356,0.009981775,-0.047547407,0.028537834,-0.04832362,-5.9118196e-05,-0.010703804,-0.077258214,-0.08638473,0.044739787,-0.051108155,-0.014466319,-0.02195991,0.08282001,-0.03470859,-0.10277416,-0.050310243,0.08809638,-0.030754799,-0.051278446,-0.026455253,0.037573688,-0.09747014,-0.06959858,-0.024088457,0.00860335,0.07705569,-0.012590922,0.004763528,-0.0055896835,-0.02221542,0.028393371,0.0130414525,0.04804135,0.011401433,0.0028118114,0.11197333,-0.010576507,-0.024880677,0.030854894,-0.08607792,0.0030100897,-0.0069305403,-0.103506275,-0.06552445,-0.05059728,0.04269892,-0.008697015,0.21896239,-0.05946478 +4.4.1.43,"A pyridoxal 5'-phosphate protein. The enzyme, characterized from the bacterium Pseudomonas canavaninivorans, cleaves a carbon-oxygen bond, releasing N-hydroxyguanidine and an unstable enamine product that tautomerizes to an imine form, which is attacked by a water molecule to form L-homoserine.",384,0.99999994,-0.08253849,-0.05334716,-0.08270532,-0.066785455,0.049590427,0.056146473,0.000765948,0.018026717,0.017880639,0.041353576,0.062484313,-0.029842868,-0.076255314,0.1368063,-0.063134,0.06322218,-0.09752606,-0.008765255,0.040685773,-0.0017950637,0.09861132,0.097467124,-0.038402624,0.03833698,-0.0023330224,0.088854544,0.054549493,0.020364251,0.00721369,-0.0569898,-0.04188542,-0.04244275,0.038803004,-0.10186283,0.09451607,0.09165458,-0.052191064,-0.036663406,0.069592886,0.013270727,0.042934086,-0.028918162,-0.039511196,0.0039613773,-0.04416842,-0.031473767,0.03798462,0.07889678,0.059821483,-0.02735735,-0.08634043,-0.037060257,-0.034888085,-0.0041394075,-0.011841559,0.008752028,-0.027664047,-0.016247632,-0.032735337,-0.01377717,0.06677813,0.012349955,0.007244737,0.021026757,0.056803897,-0.044585545,0.01760806,-0.033768307,-0.011946079,0.0058506103,-0.054679297,-0.042017795,0.06138711,0.022346476,-0.014753176,-0.015166465,-0.060751133,-0.018363576,0.011496414,0.015207284,0.0035223928,-0.022402713,-0.035668097,0.09362787,0.05637457,-0.026778728,0.032214638,0.044977598,0.05915268,-0.06582922,-0.025411706,-0.027343407,-0.0038513485,-0.02666456,-0.057494823,0.040027034,-0.010380607,-0.007353677,-0.02387292,-0.009383068,0.027459305,0.022785978,-0.02125221,-0.09120057,-0.07157594,-0.008363762,-0.003964956,0.05755927,0.043325324,-0.011052618,-0.0981961,0.02225091,0.0012798479,0.010018465,0.020010563,0.02507657,0.038540218,-0.0050885156,-0.022782607,0.0062236357,0.008157451,-0.045819424,0.0044891182,0.10186246,-0.04000849,0.03077145,-0.13469097,1.8800712e-33,0.09134611,0.02314227,0.017262952,0.035080485,-0.023456052,-0.029547311,-0.07401819,-0.012526156,-0.06870526,-0.033102956,-0.00017449356,-0.022117902,0.068779364,0.036985278,-0.036400028,-0.028672442,-0.08688481,0.0734356,0.091644384,0.05753087,0.019224377,0.15220025,-0.03441689,0.06911555,0.021334564,0.07099711,-0.0034056562,-0.038295947,0.03505736,-0.011940888,0.030937651,-0.06972136,-0.12493018,-0.034039088,0.08368254,-0.0717847,-0.013257759,-0.04547108,-0.036108665,0.021386847,-0.034502197,0.0026913837,-0.040648967,0.007118468,0.053172488,-0.063440144,-0.019824103,0.08414003,-0.03089808,0.040245846,0.038193792,-0.06370749,0.05221234,-0.0115989745,-0.15391266,-0.01555815,-0.0006775299,0.012397461,-0.011702097,0.032875746,0.053606197,-0.0020185185,-0.04902175,-0.029180104,-0.028148016,-0.036485784,0.004424461,-0.05702435,0.13733661,0.06936024,-0.076384254,0.032886393,0.02459944,0.062088966,-0.0046836357,-0.06115364,-0.08847799,0.012692791,-0.015939193,0.057816915,-0.008456487,-0.09133171,0.010560818,-0.049652018,-0.08409677,-0.016482178,0.028600221,-0.086224645,-0.002817805,-0.012514154,0.03216785,-0.12278297,-0.015334858,0.0189671,-0.0035953308,-2.6652847e-33,0.11036611,-0.12947619,0.044273317,-0.011837022,-0.04266517,0.020313045,0.019769486,0.046015482,-0.018982062,-0.04748673,0.06554759,0.0017750919,0.06400843,-0.012269605,0.03895927,0.02515326,0.011933931,-0.01590483,0.053340267,0.015176135,0.01722597,0.01657672,0.024189789,0.072057314,0.08468014,0.12127862,-0.011789815,0.03368301,0.018081356,0.025139045,-0.045201104,0.03779595,-0.024611976,-0.07599846,-0.03086832,0.055428013,-0.070092425,-0.00017552444,0.011305455,-0.015002999,0.047548868,0.0735152,0.03643584,0.020709645,-0.050138664,0.031445473,-0.03590119,-0.009308363,-0.0088909315,-0.034846637,0.024317559,0.03410253,-0.013522707,-0.031018503,0.039904244,-0.0059141675,-0.068632,0.011226271,-0.022566296,0.0329225,-0.016139984,-0.08452449,-0.013657227,0.05605644,0.024241704,0.042471394,-0.01208156,-0.006746922,0.032306917,-0.0011196338,0.03685253,-0.005838521,0.072957695,0.09750727,-0.057930335,-0.029285185,-0.05102861,-0.05561854,0.016948612,-0.004418993,-0.018949535,-0.042617265,-0.025910309,-0.07389253,0.04183655,-0.058544636,0.081678465,0.065989286,0.007896094,0.025752185,0.025043903,0.0024933217,-0.052899208,0.07708295,0.058680646,-4.3008665e-08,0.06683146,-0.11533393,0.047569763,-0.017242061,0.0058410787,0.027252184,0.02972886,-0.04127098,0.10832181,-0.015867082,0.064638086,-0.01629731,-0.00961664,0.049241576,0.030078148,0.049264744,-0.050823394,-0.0034239974,-0.012709314,-0.056106318,-0.09177941,-0.010648833,-0.11214806,0.031286765,0.03714918,-0.031273056,-0.0139053725,0.024326129,0.043005142,-0.021512998,-0.033689626,-0.0021222716,0.01603368,-0.025369026,-0.06264371,0.10160987,-0.048117388,-0.03362977,-0.02249809,0.021970794,0.014887277,0.04904257,-0.08126978,-0.029075624,0.046009462,0.03850161,-0.034595177,0.027909508,-0.049569547,-0.025120236,0.07209438,-0.008306025,-0.018406773,-0.048837315,-0.14040732,0.053254873,-0.017757045,-0.025767354,-0.017355038,-0.032895725,-0.04591027,0.0034943111,0.176701,-0.033842113 +4.8.1.5,"The enzyme is involved in the breakdown of glucosinolates. It can act on both aliphatic and aromatic glucosinolates, and forms nitrile-containing products. cf. EC 4.8.1.6, N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming), and EC 4.8.1.7, phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase.",384,0.99999994,-0.06224959,-0.0701652,-0.060449697,-0.035220362,-0.006182867,0.042091716,-0.028933203,0.0205676,0.0626082,-0.08863918,-0.0019578172,0.031172043,-0.054878335,0.02097171,-0.105123565,0.029655343,-0.020756923,0.019375127,-0.06426184,-0.13796975,0.07659126,0.03272103,-0.044553477,-0.040932253,0.03245662,-0.005113851,0.003948261,-0.05296877,-0.026362784,-0.05725122,0.03078875,-0.04806658,0.004748367,-0.014717458,0.017918864,0.039240576,-0.056877505,-0.010561293,-0.0027399822,-0.023021145,0.046658542,-0.053664077,-0.045006476,-0.03189572,0.020267224,-0.036159188,-0.015710093,0.03867985,0.03389832,-0.014010621,-0.066751234,-0.08112209,0.0032535726,0.05295212,0.061589103,-0.011698926,-0.07827369,-0.039468884,0.0035918495,0.06923549,0.041591316,0.07587455,-0.026538102,-0.028405007,-0.011458153,-0.011105189,0.11931846,-0.058888637,0.004528707,-0.04795829,-0.046661418,-0.03634981,-0.06912461,0.000661659,0.03517705,0.030709637,-0.021105742,-0.03490574,0.05606826,-0.019379735,0.1211331,0.12660156,0.066135116,0.051369883,0.0076247244,-0.0022632407,-0.0043819393,0.033182226,0.06325666,-0.01181157,0.0022573946,-0.0666711,-0.08410173,-0.0067207357,-0.022204502,0.010421346,-0.06825899,0.061558165,0.000545499,0.008445901,-0.004430207,-0.007607908,-0.00046758834,-0.08555115,-0.11314385,0.031234486,0.053498365,0.05607897,0.054797057,0.053840347,-0.030091185,0.026347587,-0.0038357275,-0.03745551,-0.06597229,0.10174157,0.044719927,0.0082602175,-0.099664725,0.041193772,-0.036337953,0.025389004,-0.005990068,0.038849607,-0.036137626,0.08062292,-0.0411549,3.315836e-33,0.09424026,0.022551244,0.05155891,-0.021444172,0.022105096,-0.018003257,-0.0896242,0.004217054,0.0013266244,-0.02770454,-0.048381694,-0.053144597,-0.044950873,0.027813496,-0.0064724875,0.061533663,0.030380886,0.010672036,0.047495987,-0.00742213,-0.0058008623,0.026584636,-0.10609079,-0.009848339,-0.042158164,0.03419539,-0.023504844,0.028223787,0.006470849,-0.019406063,0.014883969,-0.12353268,-0.035074063,0.015249326,0.056637,-0.014377554,-0.061641682,-0.049384467,0.027921014,0.027649108,-0.060570378,0.062738515,0.012882938,-0.01372432,-0.007035119,-0.029312534,-0.10676441,0.082471944,0.09519906,0.11891364,0.042576227,-0.03443271,0.10246158,-0.013732722,-0.0454388,0.08477028,-0.0015501633,-0.04149857,0.07418508,0.014015204,-0.012905131,0.013681491,-0.0046576634,-0.0531308,0.013406968,0.053879794,-0.090169154,-0.005143471,-0.011832881,0.059174508,-0.11370778,-0.033335045,-0.015068463,0.029270034,0.031186583,-0.09128265,-0.022770237,0.010880256,0.05003743,0.017020594,0.018190313,-0.026208257,0.033744458,-0.02453471,-0.13045722,0.042022742,-0.04601678,-0.041690685,-0.011507987,-0.00668599,0.0035081187,-0.055703145,-0.07360002,0.030402511,0.058438513,-4.9122157e-33,0.12765726,-0.06315525,0.03217573,-0.11045828,-0.04100942,0.027923202,0.00041142575,0.00587104,0.007797419,0.060425363,0.05476072,-0.008586064,0.055812757,-0.0009492823,-0.0025076189,-0.0047135176,0.033384185,0.06916721,0.019728515,0.01069191,-0.02927835,0.059519038,-0.0066106403,-0.033783656,0.06664093,-0.05474125,0.03411391,0.073976964,0.09113301,0.0149873495,-0.00359314,-0.039015673,-0.0653056,-0.045643557,0.017515147,0.02370353,0.010863267,-0.0082441475,-0.03358605,-0.062173657,0.036215838,0.032040175,0.06590162,0.12912777,0.04155144,0.07054058,-0.08290078,-0.0071648825,-0.01265665,-0.094606884,0.041345414,0.08905581,0.012172233,0.05308562,0.030840715,0.10014113,0.07433655,-0.026419308,-0.07184124,-0.047137864,-0.10692186,-0.043255202,0.00042650546,-0.048512693,0.030469539,0.033413727,-0.05219966,0.0023077726,0.061337937,-0.017531492,0.012807128,-0.012811707,0.039504156,-0.02546513,-0.11598105,-0.04197774,-0.042075675,-0.04935001,-0.00092118117,-0.013363522,0.07474818,-0.010065987,0.009842993,-0.09009285,-0.001214297,-0.09637651,0.034530405,0.11761441,0.04381218,0.044823367,-0.010854614,0.03770101,-0.06899195,0.01996497,-0.05608241,-4.857441e-08,0.023633948,-0.040204912,0.021373935,-0.012029869,-0.0036092207,0.022331486,0.079224415,-0.0021987732,0.0052854656,0.043021437,-0.031823616,0.08391954,-0.049621724,-0.0126906,0.01771791,0.04894952,-0.007654194,0.037690457,0.0021010751,0.031680603,-0.05140062,-0.023019474,-0.092323326,0.0554357,0.02092681,-0.08781152,0.100253195,0.042631373,-0.017752351,-0.004328803,-0.026101721,0.04917458,-0.007905551,-0.033824287,-0.08501504,0.048333675,-0.067493156,0.009873724,-0.005959569,-0.031253267,-0.012716083,0.029116845,-0.006639667,0.024554463,0.032514434,0.0093252165,-0.000176521,0.01676351,-0.003079009,0.05036286,0.027120842,-0.046818983,0.0038272073,-0.029060077,-0.096340425,0.020053817,0.050708763,-0.08028603,0.02637853,-0.03373106,-0.015224598,-0.018452333,0.19017492,0.04231791 +4.8.1.6,"The enzyme is involved in the breakdown of glucosinolates. It acts only on aliphatic N-(sulfonatooxy)alkenimidothioic acids produced from omega-alkenyl-glucosinolates, and forms epithionitrile-containing products. cf. EC 4.8.1.5, thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming), and EC 4.8.1.7, phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase.",384,1.0,-0.05271469,-0.07773568,-0.07401132,-0.046014287,0.010077699,0.05876583,-0.06523938,0.03666045,0.055577785,-0.07238055,0.012981343,0.03792895,-0.05456815,-0.00080671563,-0.09086767,0.04019018,-0.023935316,0.036852553,-0.08066601,-0.14998034,0.088617615,0.020763522,-0.04458828,-0.032350246,0.05128159,-0.007925551,0.004657354,-0.045229543,-0.023264347,-0.052459184,-0.008775684,-0.07051449,0.031930793,-0.013595899,0.017173415,0.06763299,-0.052778523,-0.021090316,-0.0077888,-0.036912803,0.049965855,-0.032129917,-0.051053595,-0.03087982,0.0067415526,-0.072622456,-0.019891784,0.043625392,0.02341623,0.007369296,-0.06640975,-0.071671344,0.0017756664,0.054300845,0.039638173,0.005547154,-0.05631459,-0.029446358,0.011306873,0.049004316,0.032020643,0.052755367,-0.009195544,-0.026716221,-0.035580467,-0.014716326,0.119508274,-0.06829909,-0.002841991,-0.027997207,-0.05037131,-0.013260713,-0.042946544,0.02806039,0.0379564,0.045531277,-0.04972058,-0.04322153,0.0660008,-0.008677798,0.10336043,0.07355121,0.041167364,0.06517758,0.0036124939,-0.01798713,-0.0023780835,0.039206646,0.07705173,-0.0109607,-0.008249984,-0.07172644,-0.0865237,-0.02090974,-0.0008016885,0.028517203,-0.045633674,0.05180624,-0.0011675418,-0.0225625,-0.027431775,-0.015864937,0.0025038728,-0.10546192,-0.09049054,0.039366513,0.022958143,0.07721586,0.02921716,0.057351526,-0.02122226,0.020856485,0.015520929,-0.021119067,-0.05293765,0.11453671,0.043776873,-0.024162129,-0.10499078,0.047018204,-0.036891993,0.020361595,0.019413713,0.056651007,-0.027606035,0.045943968,-0.042321853,3.1169056e-33,0.11155509,0.028240466,0.05988616,-0.057204902,0.053442083,-0.02574956,-0.08902535,0.025935797,0.030421605,-0.0034259364,-0.06278259,-0.038602237,-0.029439423,0.011198858,0.0013851537,0.049625512,0.03256698,0.022459542,0.029959356,-0.0002844338,-0.009521297,0.007836601,-0.09077305,-0.0034356194,-0.05484274,0.04082162,-0.00621351,0.03448996,0.015144429,-0.005750071,0.00258836,-0.14042392,-0.025876818,0.01679048,0.077271596,-0.012117875,-0.06639337,-0.036185544,0.028258514,0.02445041,-0.025041832,0.03449996,0.015896438,-0.039854147,0.012855695,-0.049901854,-0.10157162,0.07284918,0.095265426,0.13124125,0.054051064,-0.042045236,0.0872985,-0.0019410095,-0.048294112,0.052966356,-0.012121338,-0.033202667,0.05194987,0.03495751,-0.024100313,0.038686857,0.004023402,-0.04958108,-0.022786856,0.045532167,-0.08260022,-0.008749988,-0.033360485,0.050289404,-0.08374867,-0.052094825,-0.045491427,0.038788408,0.034880813,-0.084777296,-0.020001782,0.055870775,0.04533603,0.0074009416,0.016735805,-0.0021580358,0.015462899,-0.01228627,-0.14035991,0.043157488,-0.04122791,-0.024086762,-0.0119548775,0.01605839,0.011164806,-0.045250006,-0.041856952,0.053760123,0.040911704,-4.6542946e-33,0.11121478,-0.06394363,0.07743555,-0.107376754,-0.04924764,0.05179719,-0.007155044,0.030956918,0.025403792,0.02861716,0.04098958,-0.007825918,0.03722525,-0.013983656,-0.012155913,0.0056548845,0.049135834,0.07682274,0.013908397,-0.003148153,-0.00200926,0.050510254,-0.00076623063,-0.008094474,0.07584696,-0.04197866,0.04287087,0.08454445,0.088136144,0.057504702,-0.007837415,-0.018992463,-0.07625994,-0.044844415,-0.017609393,0.021852512,-0.021149635,-0.0009554075,-0.015185059,-0.03692801,0.03565679,0.018221557,0.030858928,0.11902771,0.03805272,0.07588693,-0.06841567,-0.017762301,-0.007169866,-0.106234655,0.053883232,0.07857478,0.023630904,0.043812823,0.011098657,0.119133815,0.03877106,-0.018888056,-0.07627096,-0.053226866,-0.08684746,-0.07124843,-0.0050726435,-0.032682627,0.01965738,0.034268096,-0.042702533,-0.013871786,0.034729764,-0.0039055585,0.008834908,-0.016017582,0.008834594,-0.012139516,-0.08803848,-0.022593606,-0.06511896,-0.053442635,0.004355988,-0.018717185,0.051855847,0.019694014,0.0007385454,-0.08494257,0.010028135,-0.09634931,0.02353522,0.1141061,0.04170875,0.07661589,-0.039688956,0.03720103,-0.08602005,0.02074393,-0.022066254,-4.9394565e-08,0.031238068,-0.025982985,0.027210126,0.0037886403,-0.0077163815,0.018286707,0.067704946,0.009604852,0.017842328,0.035069592,-0.051658936,0.09124561,-0.04354156,-0.0036136166,0.004781427,0.028734239,-0.003956128,0.055003792,0.006946859,0.02791848,-0.061515987,-0.028620075,-0.08762444,0.047102693,0.026115483,-0.08071336,0.11220545,0.042344943,-0.034856647,0.016513268,-0.0145644825,0.030956006,-0.029742133,-0.035294104,-0.08323317,0.04624226,-0.06701077,-0.00359687,-0.016886318,-0.034292255,-0.022553995,0.043207046,-0.022245295,0.03416026,0.042796973,0.010014196,0.016067432,0.044250075,-0.02763955,0.04477744,0.041968923,-0.053070955,0.00177703,-0.09345529,-0.1063484,0.004012685,0.061063077,-0.09876076,0.007953848,-0.020374736,-0.023720922,-0.025560662,0.21577044,0.02411252 +4.8.1.7,"The enzyme, characterized from the plant Lepidium sativum, is involved in the breakdown of the glucosinolate glucotropaeolin. Depending on the substrate, it can also form simple nitrile- and epithionitrile-containing products. cf. EC 4.8.1.5, thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming), and EC 4.8.1.6, N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming).",384,1.0,-0.052594528,-0.03821063,-0.07772573,-0.03929558,0.042693563,0.033852663,-0.0629037,0.06867212,0.03802403,-0.076363064,0.05896371,-0.02458359,-0.030322239,-0.024660237,-0.058113012,-0.0070843385,-0.045916107,0.04407748,-0.07445128,-0.12177402,0.07716629,0.036825065,-0.030263573,-0.006019788,0.046006948,0.03766309,-0.008068692,-0.0417073,0.021414101,-0.090434305,-0.03669737,-0.032226775,0.042999543,-0.027935747,0.042934004,0.028528513,-0.06987235,0.009615134,-0.016093532,-0.074612856,0.058131587,-0.06417776,-0.02843489,0.007890823,-0.046838254,-0.02540541,-0.0052652447,0.05034272,-0.011678053,0.017263126,-0.027509322,-0.08639098,-0.005587589,0.03574912,0.043687012,-0.0112049375,-0.037809644,-0.009796683,0.00820398,0.079584114,0.059210993,0.04784325,-0.04199471,-0.040785506,-0.008926611,0.01541616,0.056071416,-0.052574925,0.037493654,-0.023894027,-0.009539974,-0.027242744,-0.053384233,0.048619393,0.03466079,0.06771527,-0.04899083,-0.009039502,0.07052409,-0.013573071,0.085409716,0.13875394,0.051207386,0.08230741,-0.014550085,-0.014349027,0.011121869,0.07429272,0.049594235,-0.043402456,0.05405123,0.006286566,-0.12016294,-0.0066405376,-0.002696778,0.10079094,-0.04677671,-0.0061451336,-0.007885786,-0.03902162,0.013472392,-0.02236135,-0.03439787,-0.09237204,-0.08222056,0.024055671,0.012986568,0.01190801,0.016417855,0.023590136,-0.042154443,-0.026729371,-0.032444842,-0.014941729,-0.0840544,0.03968335,0.05150487,-0.0108517045,-0.101879716,0.012811902,-0.0066612163,0.026272845,-0.009108804,0.0391229,-0.040186282,0.026346633,-0.061410423,1.7956093e-33,0.10193548,0.043654162,-0.041081876,-0.007534758,0.00694072,-0.007273681,-0.056475017,0.05357994,-0.00075688836,-0.008097812,-0.09303337,-0.08857935,-0.065587394,0.023843452,-0.0013437693,0.034661617,-0.01887499,0.026670612,0.07915207,0.003204873,-0.0007499602,0.04653136,-0.099516,-0.020440483,-0.034743417,0.033046875,-0.0018160567,-0.0024160382,0.019017428,-0.035010133,0.071778975,-0.17158224,-0.030237174,0.02245081,0.07688243,0.027649038,-0.021209085,-0.018600855,-0.0054473155,0.06847078,-0.026786136,0.09427162,0.027146,-0.03171688,0.04284414,-0.047493663,-0.08649711,0.06257049,0.0806351,0.055781893,0.047871448,0.008011259,0.11012609,-0.019463748,-0.04039055,0.058701955,0.031045185,0.021386556,0.016636452,0.00897043,-0.012187859,0.08027356,-0.038304538,-0.012170288,0.037877608,0.059173837,-0.12260204,0.004764561,-0.031907354,0.043014742,-0.060975187,-0.045030516,-0.065191194,-0.009280303,0.009293709,-0.0751481,-0.0469344,0.0460743,0.015800593,-0.0055721817,0.048875034,-0.0074530686,0.018921524,-0.04008341,-0.117423154,0.019942231,-0.06440621,0.005335195,-0.00022880107,-0.005899829,0.018931592,-0.03114717,-0.047397807,0.03287938,0.031777367,-2.5814616e-33,0.07450225,-0.07759451,0.09290482,-0.039115455,-0.006821783,0.07412599,-0.0345505,0.0023171746,0.049704004,0.074210584,0.029707327,0.0190575,0.054125927,0.003390485,-0.004991807,0.0003011083,-0.0074045514,0.09446578,0.05038326,-0.008725413,-0.08740989,0.08756516,0.0035673534,-0.00051067636,0.07889839,-0.03388306,0.07409828,0.0660002,0.085343905,0.011825147,0.028439054,-0.04145496,-0.063639246,-0.022133403,-0.011604993,0.010160209,0.010016884,-0.021575673,-0.02649449,-0.029600888,-0.0142789595,0.005304247,0.07864347,0.071465954,0.051166542,0.020561744,-0.09614605,0.045299467,-0.020490743,-0.037217733,0.04638789,0.009482149,-0.006917073,0.06346537,0.048279807,0.04875619,0.048114352,0.004031036,-0.040360156,-0.08461354,-0.075804085,-0.059063643,-0.06188996,-0.0206672,0.04869812,0.050406415,-0.04399718,-0.006435581,0.011890684,0.01681412,0.06638551,0.0124848625,0.0038472957,-0.0145222675,-0.05061736,0.028574934,0.023417061,-0.05742829,0.00020621927,-0.05951775,0.068485945,0.021403933,0.010339494,-0.104853794,0.0112634385,-0.05895927,0.014890936,0.143063,0.04396057,0.057004284,-0.014846423,0.024242269,-0.07053744,0.07022816,0.025666758,-4.886251e-08,0.022539062,-0.03400328,0.00031812975,-0.045334257,-0.010899929,-0.035987325,0.10915555,-0.010867064,0.059165426,0.028120413,-0.06418143,0.08472876,-0.06410178,-0.020296322,0.03629684,0.017946789,0.02965527,0.062176585,-0.0056657162,0.04287995,-0.05797778,-0.02906665,-0.05467412,0.020774834,0.0088894125,-0.09789746,0.114516795,-0.00732317,-0.0035887682,0.03507459,0.015625454,0.03792877,0.0057325237,-0.08145525,-0.0680481,0.06464663,-0.037036683,-0.0045546154,-0.008860941,-0.015968343,-0.022991274,0.013537318,-0.012929113,-0.03152007,0.0020271598,-0.050526317,-0.002086154,0.029991647,-0.028578883,0.020816391,-0.008589262,-0.072300136,0.00596444,-0.08905536,-0.111783236,0.0031502203,0.06662641,-0.05770694,0.04680667,-0.06287625,-0.04821611,0.012577079,0.21776737,0.059852492 +4.8.1.8,"The enzyme, characterized from the plant Thlaspi arvense, is involved in the breakdown of the glucosinolate sinigrin. Depending on the substrate, it can also form simple nitrile-containing products. cf. EC 4.8.1.5, thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming) and EC 4.8.1.6, N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming).",384,1.0,-0.08615155,-0.0255094,-0.09366456,-0.014402077,0.026144547,0.015663708,-0.015593906,0.021179402,0.0739049,-0.042612493,0.017942525,0.0138615705,-0.08365467,-0.016640045,-0.068815514,-0.05765108,-0.080435894,0.010437889,-0.053194612,-0.10497403,0.07583759,0.057357352,-0.029186571,-0.0542511,0.08066686,0.022068491,0.012352407,-0.02635259,0.021725947,-0.09947169,0.0055285096,0.0051348573,-0.010934003,-0.044781853,0.016157566,0.069648944,-0.080029815,-0.032174863,-0.013805891,-0.06793355,0.005960021,-0.06268294,-0.044710007,-0.043388046,-0.033236157,-0.012938257,0.005697393,0.056982823,-4.03042e-06,0.010114131,-0.040732894,-0.061904006,0.017732883,-0.015238457,0.03652716,-0.024468718,-0.068119444,-0.072263375,0.026519483,0.07737535,0.0816492,0.06444004,-0.08591709,-0.0029896724,-0.046956323,-0.0021061166,0.10177209,-0.029991625,0.016045146,-0.01976918,0.002903525,-0.013991105,-0.06772111,0.048362944,-0.0028881347,0.047887698,0.027639734,-0.04702294,0.07107327,0.016159762,0.07643538,0.18485844,0.06523869,0.07869129,0.0017994244,0.030885186,0.001135404,0.042963736,0.040267747,-0.0105868345,0.060675632,0.045445036,-0.06659039,-0.045878567,0.00032004865,0.04715453,-0.04435688,0.027814768,-0.018796772,-0.009214365,0.0069230036,0.0048811547,0.011586172,-0.07787213,-0.043935854,0.033394225,0.019004764,0.005677815,0.08911515,0.03698948,-0.055777404,-0.011330895,-0.04675794,-0.03423284,-0.060670655,0.07050272,0.020748701,-0.030398713,-0.087983824,0.003761843,-0.045550264,0.030755753,-0.039181575,0.08256698,-0.042857606,0.042056926,-0.041993186,1.0437298e-33,0.07951576,0.065414004,-0.038556214,-0.0072868867,0.024514668,-0.03522069,-0.07454206,0.020052694,0.008626039,-0.0038449352,-0.10769904,-0.09391209,-0.085695036,0.031974554,0.05227071,0.01685446,0.00015670471,0.034417216,0.03513858,-0.00438958,-0.0065853,0.014930145,-0.09114304,0.008104498,-0.048937686,0.05795705,0.03611924,0.051636767,0.0273229,-0.05028856,0.0942488,-0.14540005,0.04237753,0.013689777,0.05040822,-0.002151483,-0.052593138,0.025238404,0.01759011,0.0769404,-0.011350849,0.07529845,0.02685718,-0.00036565313,0.020612128,-0.065750524,-0.09843174,0.047073826,0.05585056,0.063963436,0.020387694,0.023429327,0.11328074,-0.029453004,-0.024707144,0.09020109,0.022136541,0.008363848,0.034941457,0.009320185,-0.027454969,0.028830266,0.015698172,-0.011790386,0.016271824,0.07080991,-0.0739805,-0.03666551,0.013122059,0.028328154,-0.07046032,-0.01316497,0.00014293371,-0.040897857,0.08689335,-0.05039281,-0.033709627,0.027909908,0.0065442054,-0.005067913,0.0034646383,-0.012226451,0.054306228,-0.0022492493,-0.08866533,-0.015423682,0.00089700415,-0.01949489,-0.013243461,-0.0003466466,0.010329369,-0.07694335,-0.074690714,-0.028195534,0.033224646,-2.094838e-33,0.103187114,-0.06301384,0.046531472,-0.09371374,-0.049466267,0.084636934,-0.0033453705,-0.029607864,-0.035694536,0.061727576,0.04823627,0.0075088954,0.03208212,-0.011497858,0.004111995,-0.04435789,0.0507743,0.07094939,-0.0041434476,0.006145618,-0.08782814,0.049058422,0.040633287,-0.056758218,0.090953596,-0.04428858,0.061474983,0.016267082,0.038011037,-0.008965316,0.015669318,-0.04918671,-0.06146517,-0.032576066,0.02581208,0.03708049,0.035100393,-0.021597655,-0.044417106,-0.041057408,0.041982923,0.004087957,0.049778633,0.10955499,0.0073652137,0.005723963,-0.06267705,-0.01491934,-0.052196823,-0.045924943,0.066022255,0.048992716,0.011422668,0.069545336,0.03953694,0.030605875,0.07854981,-0.020933794,-0.042736024,-0.06184105,-0.115513064,-0.05469754,0.006049455,-0.0427201,0.055744085,0.028068705,-0.047995545,0.02973189,0.0553148,-0.029529443,0.046697397,0.02117422,0.054694243,-0.02682414,-0.06864893,-0.032846574,0.031899855,-0.061396673,-0.0060650837,-0.09861829,0.054374926,-0.006109219,-0.056027673,-0.07757648,-0.019345727,-0.07912478,0.051275983,0.104666114,0.018395962,0.07885092,-0.020760307,0.068701185,-0.060835503,0.04666894,0.026128408,-4.413781e-08,0.024883538,-0.022995135,-0.03242292,-0.04939847,0.034822356,0.03867462,0.06768853,-0.008355447,0.026466252,0.056430947,-0.03189325,0.12139641,-0.06366395,-0.035964463,0.02048009,0.011557901,-0.007550773,0.045494948,0.0048943013,0.023140792,-0.039801486,0.04015505,-0.094830304,0.040670514,0.021660972,-0.070659846,0.06743606,-0.04125715,0.015452898,0.034609508,0.020694103,0.077713236,-0.038162377,-0.042506665,-0.02957183,0.03958282,-0.051570944,0.019617075,-0.037016682,-0.022624541,-0.05680261,0.055374242,-0.026806308,0.008408903,-0.032970153,-0.03763336,-0.004149654,0.021447895,-0.0025121183,0.045548927,-0.019521246,-0.036296435,0.0047268053,-0.10158364,-0.12650634,-0.012739284,0.08593832,-0.08127886,0.013156323,0.0064062816,-0.0060717305,-0.003369373,0.1706194,0.07702687 +5.3.3.24,"The enzyme, characterized from the opium poppy (Papaver somniferum), participates in the biosynthesis of morphine. It also catalyses the isomerization of neomorphinone and morphinone.",384,1.0,0.03233489,-0.028249647,-0.08591631,0.01640253,0.009352253,0.06275009,-0.0775405,0.011087765,0.0426276,-0.07238569,0.011804989,0.015482328,-0.026776057,0.009831226,0.004432965,0.0466141,-0.052623685,0.043838043,0.03200306,-0.013433307,0.13257407,-0.017243905,0.04375366,0.044732116,0.00026724438,0.074095316,0.008464089,0.004318309,0.0050509707,-0.07049199,0.057621043,-0.008476397,0.0045055132,-0.012772925,-0.02531571,0.021170074,-0.054076992,-0.001960691,0.15292059,0.0013953403,0.07865897,-0.055103905,-0.07230221,-0.028482884,0.014290554,0.0031549789,-0.032535806,-0.017513664,-0.032470413,-0.04365105,0.0081592705,-0.07462623,-0.08218578,0.08463661,0.0009056845,-0.01970558,0.055853978,0.011675807,-0.00983684,0.016510077,-0.013652953,0.06939046,0.025140265,0.016852325,0.018711181,-0.053690955,0.008941278,-0.012556234,-0.008452323,-0.034520175,-0.016249115,-0.05110826,0.045284398,0.02333926,-0.05144798,0.012192117,-0.05067072,0.008881696,-0.026994854,0.008310969,0.13231382,0.030207533,-0.010589301,0.10320105,0.021719016,-0.00062080764,-0.025077894,0.041640695,0.022250485,0.0032335813,0.06215922,0.0037460648,-0.09041191,0.029600397,-0.010981838,-0.04673672,0.060362246,0.0038611605,-0.029449685,-0.019539991,0.007303344,0.046500374,-0.105045736,-0.1122884,-0.024533844,0.008343276,-0.028343517,-0.004831673,0.038405165,0.05226312,-0.031997826,-0.08207669,0.002540539,0.03450629,-0.066383995,0.06626619,0.04086158,0.0020341566,-0.06384506,-0.050522596,-0.005189151,0.006390605,0.0046455325,0.12745064,0.013026929,-0.019040303,-0.106846616,8.802719e-34,0.029683677,0.05263731,-0.023728224,0.010319279,-0.008461987,-0.02983784,0.069607854,0.02010291,0.021086121,-0.082884714,-0.08341382,-0.035914574,-0.021848686,0.04727033,0.00077273813,-0.051140368,-0.023865087,-0.0008347674,0.034404606,-0.06795823,-0.042929254,0.03109333,-0.09604712,0.007420238,-0.0016488811,0.0647942,-0.09040694,-0.040352535,0.027783263,-0.028325409,0.04196953,-0.0028338996,-0.06694159,0.022918383,0.10480065,0.0030817883,0.010798893,-0.06219089,-0.09983934,-0.0059274333,-0.0606781,-0.005721495,0.043362044,-0.005254657,-0.0045955544,-0.043467913,-0.08595158,0.06774977,0.09346073,0.023799825,0.02950899,-0.039788906,0.010690204,-0.031540968,-0.07387919,0.024812343,-0.05487305,-0.057453856,-0.002204459,0.013053931,0.016398272,-0.048106432,0.011823912,0.021774769,0.04668229,0.027618902,-0.060028758,-0.0021007704,-0.0071703033,0.15987016,-0.077907756,0.0025130732,0.010313822,0.037185036,0.006015101,0.06788671,-0.036622033,0.022619547,0.020038836,-0.02046016,0.013274615,-0.07529175,-0.04258983,-0.043453418,-0.025342304,0.036650684,0.06371662,-0.000623216,0.007990514,0.074001186,-0.02204904,-0.06436592,-0.079089105,-0.0005175085,0.004151997,-2.5569136e-33,0.06224616,-0.06686438,0.0006412789,-0.014798538,-0.034075994,0.07105443,-0.060840163,0.027437432,-0.021308415,0.09381866,-0.043639265,-0.0043803067,0.12707019,-0.030457456,-0.020492734,-0.013025581,-0.008557899,0.07207583,-0.01223686,-0.0030074231,-0.047604274,0.10584267,-0.068150155,0.038053945,0.027812071,0.026058039,-0.021644577,0.054063726,0.07457289,0.053620853,0.035619028,-0.03705295,-0.057541102,-0.06353538,-0.017051598,0.19247164,0.013472111,0.020489011,0.0008199697,-0.007046977,-0.06347283,-0.049578644,0.014349389,0.06327759,0.058535747,-0.029316412,-0.044680156,0.06047251,0.10247698,-0.026811272,0.03082899,0.064346164,-0.0046953587,-0.004573057,-0.0059998254,-0.013522887,-0.055124566,-0.09025784,-0.070413694,-0.12177472,-0.009126857,0.027268955,-0.03724044,-0.06879176,0.007482747,-0.011574732,-0.019905398,-0.01199633,0.04638857,0.030907985,0.06819521,0.0031813341,0.007015793,0.071281545,-0.0013261074,-0.07992346,-0.09344172,-0.049987197,-0.014930884,0.018159399,0.03514604,0.026772788,0.05803568,-0.032968134,-0.065841235,-0.023424983,0.06014953,0.13106361,-0.017251285,-0.0375504,0.048989937,-0.0044424003,-0.07441281,0.033109374,-0.012800538,-3.123078e-08,-0.008751396,-0.041855175,0.0708189,-0.0014075782,-0.034493726,0.014905462,0.024644498,-0.05708173,-0.008755595,-0.05344917,-0.015017282,0.03391262,-0.02511651,0.025856929,0.030283276,-0.027750082,-0.052997645,0.08141414,-0.011064449,-0.020495174,-0.06749096,-0.038603157,-0.08365043,-0.033829525,0.076279506,-0.003036174,0.018404681,0.039827723,0.00025026762,0.062410057,0.09294606,-0.017094688,0.0074149743,-0.017933153,-0.05809452,0.06534944,0.011636366,-0.031952165,0.015235609,-0.015619786,0.052949663,-0.074067675,-0.05901162,0.05828278,0.0059265797,0.0016668686,0.026172241,-0.09845028,-0.013427914,0.0039990083,0.044188637,-0.023972865,0.017414859,-0.022169799,-0.082607664,-0.03680631,-0.01803964,0.00034883595,0.027462035,-0.046992593,0.0034525595,0.025512159,0.2689423,0.017295763 +7.2.3.1,"Requires Na+ and K+. This enzyme, found in some bacteria and archaea, couples the energy from diphosphate hydrolysis to active sodium translocation across the membrane. The enzyme is electrogenic, as the Na+ transport results in generation of a positive potential in the inner side of the membrane.",384,1.0,-0.0857665,-0.030280767,0.0017170383,-0.0017343464,0.039703447,-0.012389779,0.053741366,-0.026207471,0.0048651677,0.060497716,-0.010579299,-0.095415674,0.0034672902,0.09289945,-0.06779972,-0.03940895,-0.03165392,0.020288993,-0.006301393,-0.033888187,0.10442096,-0.00066909264,-0.021103168,-0.043561615,0.034939595,0.0070574596,0.03976469,-0.03422434,0.03763973,-0.065079845,-0.09374933,-0.03761762,0.0032376251,-0.0826953,-0.002934075,0.12286577,-0.11184527,-0.023841368,-0.021411337,-0.006059502,0.032626808,-0.007891669,0.09424067,-0.020446079,-0.021975635,-0.07074849,0.05939495,-0.08590527,0.064401366,-0.002668744,-0.012133296,-0.037024174,-0.026492547,0.026527757,-0.009613313,0.043227445,-0.11970804,-0.020497859,-0.02976047,-0.013241506,0.01223945,0.02869351,0.047632407,-0.045912948,0.12389069,-0.090532914,0.041358702,0.038956866,0.018403456,-0.025173927,-0.044150315,-0.061036393,0.043228164,0.008192657,0.017005835,-0.008852741,0.03389915,-5.8949274e-05,0.030881062,-0.031396702,0.039434474,-0.006616358,-0.060168665,0.034688346,0.06265642,0.009868373,0.025712287,-0.044091538,0.0022921758,0.026405746,0.057842948,-0.0019289446,0.0035352202,-0.031665888,-0.0043767756,0.014766409,-0.052491058,0.02021688,-0.056896903,0.00030962413,0.0025616414,0.09646779,0.00040643694,0.0039180494,0.0063987854,-0.076417804,0.012751467,0.05148468,0.007983039,0.08133175,0.057857316,0.045456834,0.03280082,0.015570455,-0.020141374,0.074776515,0.008674848,-0.12949283,-0.03224406,0.021841055,-0.003042025,-0.089072645,-0.05632535,0.061424144,-0.03389797,0.085051514,-0.039590225,1.4720646e-33,0.0115700085,-0.014017981,0.023700584,-0.041079037,-0.046082135,-0.022407252,-0.0945927,-0.009458456,-0.034957293,-0.12239831,-0.085227944,-0.01986401,0.10476503,0.036804307,-0.06017854,0.010049982,-0.0021348537,-0.089596495,0.087647766,0.010979119,0.030780787,-0.004329909,-0.014514282,0.06665429,0.0013861825,0.012705502,-0.020437736,-0.056373514,0.040022958,0.0029834067,0.03299182,-0.085299134,-0.08109793,0.08857197,0.026608475,0.040707707,0.02102189,-0.011538402,0.054562766,0.058698047,-0.040938705,0.027001068,-0.02142278,0.05727001,0.076382816,-0.059757866,-0.025376378,0.101746224,0.011860186,0.06600603,0.010063709,-0.0472709,0.06360727,-0.0069864704,-0.059524495,0.049498726,-0.017520213,-0.004925338,0.02226212,0.026505947,-0.0047153444,0.054207798,-0.021111665,0.050714187,0.01758784,0.018901525,-0.037045784,-0.0670282,0.07416616,0.040183805,-0.093937695,-0.0058205114,0.032459527,0.06193079,0.008608384,-0.023591833,-0.09768578,0.013418191,0.027916573,0.0015645752,0.009934726,-0.0593032,0.05838666,0.023283526,-0.03490482,-0.061929166,-0.02212134,0.003558904,0.024210742,0.038781058,0.041608214,0.0191353,-0.04149246,0.0046833134,-0.01847306,-2.197275e-33,0.082415365,-0.04522772,-0.05883175,-0.068282254,-0.046004597,0.045028787,0.031043345,-0.08302833,-0.0048136273,-0.024070015,0.042916358,0.01621407,0.059049714,-0.017672518,0.0015009489,-0.019241521,-0.08501618,0.0800748,0.022063436,-0.026071649,-0.014589732,0.09992535,-0.0069292225,0.05438791,0.04179386,0.037834175,-0.06839666,0.07381252,-0.06038638,0.041082896,-0.039057907,0.06560692,-0.07550907,-0.027237276,-0.082059085,0.032936405,-0.036296465,0.010348143,0.011112158,0.070014514,0.017955892,0.058223348,0.060833592,0.016619693,0.019826878,0.049436893,-0.00024542544,0.013760107,-0.005910666,-0.12047718,0.088290125,0.0068698013,-0.027981084,-0.028236536,-0.0040822932,0.049500365,-0.015782155,0.058473248,0.0029621208,-0.017933512,-0.0045440667,-0.079948686,0.060362007,-0.1128985,-0.017678209,-0.0032108005,0.04198304,0.0305374,0.02753434,-0.038977303,0.025912981,0.087379076,0.0558634,-0.04361361,-0.049416438,-0.005476895,-0.039766837,0.013513159,0.060669236,-0.10665341,-0.02367385,0.10351601,-0.021018414,-0.102688424,0.043377973,0.015520513,-0.02266811,0.0406863,0.018448684,-0.021840826,-0.04482881,-0.08987667,-0.17139375,0.045399755,0.03199554,-3.7554162e-08,0.076304026,-0.018852126,-0.021499906,-0.06291309,0.034869663,0.113032006,0.023069737,-0.015154379,0.07634589,-0.017188914,0.014037379,0.066030495,-0.009461316,0.030411985,0.041847598,0.030429268,0.028882949,0.09650691,-0.10312755,-0.03333419,0.006483543,-0.020625705,-0.14062895,0.10555374,0.06785999,-0.006323114,0.07591495,0.003891516,-0.030140271,-0.0831926,-0.0314676,0.017229095,0.01708733,0.000600022,-0.042440988,0.06997081,0.015114828,0.022260224,-0.04769313,-0.016392598,-0.024361195,-0.034704022,-0.06747981,-0.042322103,-0.054534107,0.029700642,0.02274548,0.03301595,-0.0066222767,0.018715346,0.050477352,-0.085497,-0.0073815375,-0.030832179,-0.06320486,-0.027864631,-0.030361041,-0.09421763,-0.022482095,-0.012983782,0.094337806,0.020182412,0.1046508,-0.01513675 +2.1.1.388,"The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-proline betaine to tetrahydrofolate, as part of an L-proline betaine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway.",384,0.99999994,-0.05590439,-0.06764374,-0.10326523,-0.022219596,0.066552274,0.07648823,-0.040098276,0.038294666,0.034001835,-0.033113997,0.02456792,-0.03310827,-0.014925028,-0.06955449,-0.06996437,0.011975016,-0.068724014,-0.052759655,0.0059834705,-0.045071196,0.0087975,0.047038946,-0.06770213,0.0076756836,0.0082825925,0.036124133,0.007981626,-0.022252424,0.02577676,-0.06892832,0.028988572,0.02307817,0.0518576,-0.013057072,0.015908988,0.07857588,-0.027517868,-0.08921554,0.07062508,0.037808254,0.059086323,-0.030671764,-0.054513335,-0.015794015,-0.05599528,-0.0027887688,-0.015880853,0.01662312,0.021953905,-0.043366715,-0.04265863,-0.04420563,-0.046499707,0.033542085,-0.039996047,0.042196475,0.066002466,-0.01557879,-0.013633524,0.0062815174,0.04065422,0.06622502,-0.029329436,0.02660121,-0.0034395526,-0.032884583,0.03858265,-0.102374785,-0.002576189,-0.021202859,-0.11653033,-0.051424377,-0.046624273,0.10120666,0.0063314056,-0.026734782,0.011004094,-0.09213167,0.044954106,-0.02172584,-0.043802563,0.04164466,-0.071794726,-0.006875977,-0.040751044,-0.03877474,-0.011280919,-0.0008552888,0.10448298,0.010154269,0.029550541,-0.011479461,-0.02375658,-0.032690633,-0.093755886,0.06704523,0.063883305,-0.047617763,0.10562732,-0.006538346,-0.023073202,0.09284295,-0.029264292,-0.12672786,-0.12421067,0.001995738,0.025291217,0.1102454,0.0061821225,-0.014535083,-0.025227964,-0.06985494,0.034764357,-0.04462311,-0.055974405,0.029237295,0.04388857,-0.05653315,-0.015195783,-0.02297161,0.031071473,-0.040687595,0.09148443,0.058490913,-0.0009942236,0.039445743,-0.072236,1.0519539e-33,0.07105521,8.161202e-05,0.02105172,0.009465865,0.032604057,0.02033714,-0.09759831,0.027544906,0.0015376488,-0.042443555,-0.06909411,-0.0957637,-0.02728169,0.052203614,0.01912195,0.023548106,-0.042339597,-0.00083958136,0.052848022,0.029307036,-0.04277926,0.04586603,-0.012859524,0.01788823,0.04398484,0.091621295,0.050008595,0.03903774,0.035916124,0.020508796,0.014579954,-0.07361381,-0.10932341,-0.008602023,0.05618929,0.026974367,-0.022540826,-0.012216759,0.036564324,0.06486719,0.12851402,0.038782604,0.036763687,0.013831113,0.008049721,0.004662385,-0.013277966,0.09977968,0.014516383,0.028484588,0.0575289,-0.021637939,0.12299823,-0.048783455,-0.069323726,0.09445051,-0.055484597,0.027148446,0.01443525,0.030428275,0.021696297,0.050525274,-0.019363752,0.07881678,0.015173772,0.02295553,-0.05587562,-0.0037024955,0.036488656,-0.020829564,-0.08713778,0.02002776,0.119769305,0.06852818,0.008831511,-0.007077322,-0.07937578,-0.044162076,0.05854134,-0.028483806,-0.100625545,0.031719044,0.029483948,-0.034131274,-0.005345885,-0.0062440084,-0.016056383,-0.020281827,-0.041406088,-0.02989839,0.043186355,-0.07084573,-0.040690932,0.05287904,-0.0035906204,-2.892608e-33,0.02064501,-0.10061905,0.08863519,-0.08111635,0.006170273,0.018906178,0.00942932,-0.005478568,-0.0049696104,0.05410356,0.10868411,0.009090889,0.03304442,-0.03920484,0.03479594,-0.038373534,0.03445872,0.04315781,-0.07394597,-0.01167862,0.02706322,-0.009323482,0.031913538,-0.03499869,0.014721554,0.028445845,-0.025133746,0.05502896,0.021116855,0.053444125,0.07969897,0.006927168,-0.021238148,-0.078603506,-0.09101645,0.081548534,-0.04829456,0.005117032,0.010877834,-0.006497589,0.026712403,-0.0019639,-0.026975885,-0.020994198,0.0168797,0.05063128,-0.03280466,-0.084944434,0.021602387,-0.03757022,0.030993614,0.010555791,-0.035267983,0.047020394,0.0075189536,0.062910914,0.010610495,0.042775746,-0.008327726,-0.08471975,-0.06645442,-0.015814211,0.055844333,-0.0015331951,0.07341432,0.015104572,0.053313233,0.0149405785,0.07631874,-0.052628927,0.1164471,0.06116181,0.0047016297,0.0584095,-0.011067855,-0.03724733,-0.056430575,-0.051440805,-0.055856697,0.021966659,0.0028303743,-0.07761862,-0.029746067,-0.06347003,-0.04255019,-0.08056477,-0.028833047,0.09659948,-0.005111646,0.047646787,-0.05987389,0.010090242,-0.077201866,0.08148364,0.074996576,-3.903834e-08,-0.031395055,-0.05104895,0.013587834,-0.032512583,0.009977145,0.036771495,-0.019918587,0.022683388,0.03558009,-0.06538208,-0.034393214,0.04707279,-0.021168387,0.05373149,0.025594842,0.051633924,-0.0461494,0.008043575,-0.0015957099,-0.01803757,-0.053778045,-0.007034856,-0.019720666,0.04306597,0.009216342,-0.109919675,0.025816906,0.08452321,-0.015412793,-0.05195637,-0.02048028,0.08864456,-0.04053147,-0.0101075,-0.09974239,0.034884986,-0.008437449,-0.032013632,-0.041390855,0.09867867,0.037498005,0.017077003,-0.1585029,-0.0039551477,0.035144698,0.03939841,-0.015255688,0.079045594,-0.045166317,-0.03218563,0.015423601,-0.011214501,-0.026331808,-0.013549919,-0.061274637,-0.013825181,-0.058577813,-0.042908628,0.025209399,-0.037116487,-0.0070088366,0.008555249,0.1950912,-0.045069683 +2.1.1.389,"The enzyme, characterized from the acetogenic gut bacterium Eubacterium limosum, participates in a pathway for the degradation of some quaternary amine compounds (L-proline betaine and L-carnitine). The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (bacterial MtqC) to tetrahydrofolate. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway.",384,1.0,-0.05065692,-0.046482172,-0.15277478,0.0039777774,0.073456116,0.060043223,-0.07133307,0.00784654,0.009490162,-0.041121367,0.01976458,-0.08327019,-0.03698286,-0.06805496,-0.072448194,0.0141362455,-0.048559576,-0.052990247,0.027020296,-0.054762654,0.020945912,0.0032579824,-0.06372894,-0.015570884,-0.008115891,0.040380504,-0.0075890194,-0.043797605,0.01420595,-0.07594149,0.036108766,0.010434052,0.051783405,-0.019025696,0.025574934,0.06352454,-0.002635824,-0.090789065,0.10012366,0.045835786,0.05231264,-0.0011191203,-0.0143970745,-0.04388314,-0.036189906,-0.020777872,-0.0076823537,0.03713252,0.024426674,-0.027932862,-0.055700626,-0.041889604,-0.065904684,0.011171597,-0.026579563,0.040307865,0.008904213,-0.067652345,0.041036543,0.025499,0.06299857,0.01877437,-0.012797629,0.018382084,0.03429053,-0.04293106,0.027364243,-0.115529254,0.0042576306,-0.029040508,-0.11021837,-0.04570643,-0.054940324,0.050723013,0.0054214993,0.013747594,0.0031948378,-0.1019956,0.012766457,-0.0074515706,-0.041820604,0.07739727,-0.054053858,-0.006918357,-0.0194992,-0.015819954,-0.022438552,-0.015490765,0.0727747,0.05070134,0.050472885,-0.027507745,0.01699048,-0.012939145,-0.11789874,0.036095254,0.1115758,-0.018107193,0.058580972,-0.027169026,-0.024219261,0.070913866,-0.028085263,-0.09321721,-0.10599533,-0.010914495,0.062191088,0.14876178,0.024859903,0.03283125,-0.054979965,-0.019429864,0.008247202,-0.08017583,-0.04489802,0.0710328,0.073979355,-0.046747748,-0.03771474,0.0020288297,0.046929277,-0.04558932,0.068050824,0.010970537,0.028671624,0.035009816,-0.023096254,2.8165032e-33,0.073251605,0.030363299,0.018965188,0.02469118,0.046969555,0.008849515,-0.10451585,0.020779872,0.05267738,-0.03210797,-0.0672079,-0.0702295,-0.0009771042,0.048355956,-0.03146651,0.038349338,-0.08223833,-0.05886526,0.030881915,0.04816528,-0.0325685,0.047355555,-0.011988782,0.05252712,0.04305296,0.06640128,0.0050231945,0.05634877,0.029705366,0.036786843,-0.006789224,-0.06851994,-0.12130932,-0.027133211,0.06779942,0.018305695,-0.046324544,-0.0033593727,0.011110953,0.056967642,0.1264329,0.0258545,-0.01364874,0.016421588,-0.010438875,-0.05020532,-0.0031910392,0.07538665,-0.0012693455,-0.0058235177,0.0497446,-0.0045242845,0.086854875,-0.041480992,-0.06510829,0.053139534,-0.041713487,0.017468022,0.033449873,0.031398468,0.04255762,0.052333206,0.0045664106,0.06905814,0.0022842702,0.0189107,-0.037658256,-0.009957062,0.058091436,-0.012455448,-0.07139267,-0.030040946,0.10494787,0.0919889,0.0004132794,-0.035584882,-0.057433814,-0.043637797,0.0987002,-0.03796888,-0.046690173,0.04076277,0.08234217,-0.03456743,0.022948362,0.0042731497,-0.050018713,-0.02339626,-0.015224248,-0.027671214,0.006231471,-0.025907723,0.006454744,0.017728787,0.0039965836,-4.5217392e-33,0.05293994,-0.10613065,0.06829026,-0.07665812,-0.07482267,0.024197426,-0.009178704,-0.032714646,0.016172353,0.03381247,0.112430125,0.03137532,0.045993257,-0.03866902,0.0773609,-0.050321106,0.032984685,0.06267465,-0.08069943,-0.01639631,0.025330719,-0.015347677,0.01732668,-0.06578996,0.018334568,0.05265506,-0.04273558,0.016294857,0.049968906,0.04329477,0.049408466,-0.010045829,-0.031527378,-0.08391959,-0.07156824,0.05570037,-0.036778934,0.029336873,0.0024062807,0.0021793826,0.021555806,-0.04598275,-0.02405503,0.000113375085,0.032024957,0.005434856,-0.05852794,-0.07594761,0.016574852,0.016690593,0.06512131,0.027974354,-0.065887645,0.0304658,0.024657676,0.08622863,0.042349376,0.008308904,0.053048816,-0.07796756,-0.08839985,0.040900085,0.026470765,-0.03443606,0.09932395,0.031804513,0.046975028,0.051134534,0.043043952,-0.059918195,0.08922426,0.077708624,0.028096903,0.013268013,-0.035127465,-0.016394498,-0.06980034,-0.0118616745,-0.057498842,0.011454433,-0.017744953,-0.08047569,0.016140053,-0.053649213,-0.04898465,-0.056805234,-0.0036901543,0.08303242,-0.031663813,0.057310797,-0.051954374,-0.065151215,-0.050393604,0.050894506,0.046029598,-3.9907615e-08,-0.03885049,-0.021148622,0.0059494064,-0.03126915,0.016338468,0.09447482,-0.07666716,-0.03687149,0.06586893,-0.02696943,0.0035627238,0.06508434,0.019557122,0.08416375,-0.039672412,0.040232122,-0.056936618,-0.00046335923,-0.00069810165,0.0083448915,-0.07404428,-0.017731315,-0.0020028541,0.058001805,0.044146392,-0.10767623,0.049340703,0.09469753,-0.031559445,-0.04352465,-0.055094935,0.06312753,0.0028281854,0.018406576,-0.08044517,-0.003292232,0.009570495,-0.014831802,-0.05967587,0.07506037,0.046309203,0.014731803,-0.15683225,0.00039411042,0.0063066063,0.032048825,-0.041652277,0.09018036,-0.085415505,0.0052996306,0.00090227416,-0.049459007,-0.008298839,-0.0014830431,-0.03117126,-0.03390566,-0.034238167,-0.05881185,0.021090921,-0.03384675,0.0030921474,0.012071577,0.14346708,-0.04566832 +2.1.1.390,"The enzyme, isolated from the bacterium Micromonospora echinospora, has a single [4Fe-4S] cluster per monomer. It is a radical S-adenosyl-L-methionine (SAM) enzyme with a methylcob(III)alamin cofactor. The enzyme uses two molecues of SAM for the reaction. One molecule forms a 5'-deoxyadenosyl radical, while the other is used to methylate the cobalamin cofactor. It catalyses methylation of the 6'-carbon of gentamicin X2 (GenX2) to produce genetricin (G418) during the biosynthesis of gentamicins. The 6'-pro-R-hydrogen atom of GenX2 is stereoselectively abstracted by the 5'-deoxyadenosyl radical and methylation occurs with retention of configuration at C6'. The regeneration of cob(I)alamin from cob(III)alamin is carried out with an as yet unidentified electron donor. ",384,1.0,-0.03108175,0.012681204,-0.107947305,-0.010919761,0.055482168,0.04778967,-0.067989044,-0.006958236,0.050792288,-0.038870756,0.08593313,-0.079011954,-0.04333979,0.0071513206,0.017545786,0.056172464,-0.06711961,-0.024566028,-0.013674264,-0.078972295,0.04391451,0.032510705,-0.01997531,-0.020680109,0.028722912,0.03484461,0.09120292,0.009544423,0.014965961,-0.01637875,0.0687808,0.002007138,-0.0039373264,-0.054188352,0.021347368,0.12115452,0.02578045,-0.0077979197,0.11889689,0.031364247,0.01694624,0.07032188,0.028595395,-0.024004022,0.0014538901,-0.047842115,0.0076257177,0.02203106,0.049940336,-0.05560546,-0.01634043,-0.047930382,0.00059902255,0.0540273,0.07646701,0.02396651,-0.06112555,-0.08920713,0.027443165,-0.061865706,0.048926584,-0.062970795,0.0476082,-0.06502998,-0.007031876,-0.016738059,0.036492184,-0.15127023,0.060077593,-0.061773226,-0.087032035,-0.032081015,-0.012284035,0.05168272,-0.06429301,0.03377013,0.01639963,-0.0046415185,0.029411199,-0.0018398662,-0.004159547,0.011042778,0.040544044,0.033762224,0.010316545,-0.032307506,0.035005238,-0.01417282,0.07160075,0.022477929,-0.0031792189,0.0029276307,0.051371116,-0.09578594,-0.005481967,0.02570523,0.021427067,0.028243305,0.019634964,-0.0010433873,-0.005933175,0.03590415,-0.093614094,-0.026541395,-0.05368877,-0.021000268,-0.005384412,0.16487245,0.07075436,0.047718234,0.027366525,0.05924563,0.008015848,0.026471803,-0.028463969,0.10937615,0.030058008,-0.00034698896,-0.00907065,0.021030702,0.02879878,0.014940398,0.051645506,0.019869046,-0.023383204,0.06559215,-0.11430458,4.2760326e-33,0.06241159,0.036722053,0.003488401,0.004498442,0.0116485655,-0.057396077,-0.09653172,0.032151785,0.018413536,-0.13070488,-0.13552487,-0.060798183,0.050254337,-0.006866064,-0.05969649,-0.07047362,-0.012357931,-0.04508269,0.030145757,0.018825151,-0.05580063,0.048581447,0.0035355396,0.039208136,-0.033387896,0.097099654,0.059764277,-0.043731928,0.067946434,-0.0012630092,-0.049000006,-0.037255056,-0.05983225,0.03367707,0.055273257,0.035802346,-0.09727115,-0.024745572,0.042004086,0.05993621,-0.029318152,0.06463175,-0.031480663,-0.045809068,0.056242924,-0.031669103,-0.05668756,0.04799624,0.021954788,0.048232097,0.017201688,0.008389524,0.07331687,0.027226135,-0.067541875,-0.0026143002,0.009987981,-0.033286802,0.020056957,0.04110545,-0.030517744,0.022916699,0.0009968361,0.07104501,-0.017191987,0.013794228,-0.06376013,-0.0088283345,-0.02775566,0.0837622,0.020773565,0.008032796,0.048487913,0.08919913,-0.036429904,-0.025855608,0.040721804,0.013716671,0.03129276,-0.00010907658,0.0030522726,0.044803508,0.0044359225,-0.043956112,-0.039738078,-0.031598486,-0.037556984,-0.0193605,-0.011747086,0.045700125,-0.017572504,-0.032193743,-0.024048937,-0.037903074,-0.08693274,-5.4335133e-33,0.05425123,-0.045266878,-0.013278471,-0.08149292,-0.045439593,0.046712827,-0.009486727,-0.055741765,-0.05606086,-0.09841364,0.06385368,0.015101553,0.013055104,-0.035493746,-0.020625314,0.03159142,0.020079581,0.11831671,-0.0132067725,-0.014271946,0.05631907,0.054587092,-0.012614274,-0.019977218,0.072142765,-0.067102656,0.08146274,0.057183817,0.02060693,0.048774593,0.00035849505,-0.031969473,-0.02424628,-0.03308694,-0.007203477,0.05118697,0.012867559,-0.025009863,0.0063350853,0.0131412875,-0.016104005,0.03062224,-0.026344894,0.1347697,0.032292146,0.09552168,-0.0938335,0.016897999,-0.04629378,0.025538232,0.0058016167,-0.060863677,-0.022038385,-0.043288134,-0.062749386,0.01877099,0.070288084,0.026162261,-0.012274207,0.0036014756,-0.0041230535,-0.07112014,0.038037926,-0.013665,0.0012686168,0.025591927,0.0033977977,0.05100788,-0.0104821315,0.018911835,0.05007929,-0.030765379,0.010203763,0.009365609,-0.012316879,0.024710907,-0.06038243,0.008779781,-0.0015855975,-0.06344594,-0.03086505,0.026427513,0.060611635,-0.084557265,-0.02750771,0.0079649445,0.12496295,0.16385418,-0.040445548,0.0327041,-0.054204304,2.0661186e-05,-0.026031958,0.025333928,0.042983584,-5.4244293e-08,0.030081807,-0.14133134,0.060634762,-0.054218564,-0.0019871413,0.11622969,-0.041746747,-0.033403836,0.059082765,-0.066984124,-0.011830908,0.056001063,-0.08084134,0.04547318,-0.0784955,-0.03493557,-0.07275736,0.030251484,-0.047958013,-0.02767095,-0.080665804,0.014178356,-0.07297519,0.040484153,0.065534495,-0.107973695,0.018105056,0.09571217,-0.059578914,-0.062648445,-0.014146966,0.018222999,-0.053257633,-0.019939316,-0.13652849,-0.044263408,-0.051230777,-0.0035123222,0.0010443707,0.010988097,0.0018052326,-0.037372995,-0.040201783,0.014037601,-0.03859726,0.0006014412,0.01572484,0.027268518,-0.033082295,0.078238875,0.040940545,-0.05878783,0.0143629685,-0.045833748,-0.10585855,-0.006554451,-0.05228963,-0.07771442,0.031585496,-0.060566567,0.028042745,0.03132558,0.10446921,-0.033286836 +2.3.1.312,"The enzyme, present in bacteria and archaea, participates in a pathway for the degradation of D-glutamate. The enzyme from the marine bacterium Pseudoalteromonas sp. CF6-2 can also acetylate D-glutamine, D-aspartate, and D-asparagine with lower activity.",384,0.99999994,-0.0751302,-0.05990584,-0.022764016,-0.028548755,0.011778858,0.008548411,-0.08480439,0.034992494,0.012190917,0.021448636,-0.008723286,-0.031860605,-0.04212442,0.03872546,-0.017194772,0.028251544,-0.05732023,0.004665017,-0.039155655,0.012803488,0.067567885,0.14608458,-0.08080923,-0.041459713,0.053384077,0.04357672,0.08110895,-0.06471452,-0.003124048,-0.035484985,-0.02682567,-0.022819458,0.080752164,0.006841245,0.103595786,0.06674217,-0.03344241,-0.011888401,0.09056591,-0.055114307,0.00497624,0.07892185,0.05795819,-0.037424423,-0.042160217,0.008159593,0.012011805,0.01694712,0.028193127,-0.04863647,0.009014716,-0.06267933,-0.023889208,0.019800244,0.060999494,0.062184624,-0.05024743,-0.0599284,-0.028347174,-0.01242165,0.039988738,0.02143563,0.014569387,-0.011230239,0.053074025,-0.07511148,0.09423923,-0.019383,0.024869287,-0.042203464,-0.052481,-0.048282567,0.030646596,0.038192585,0.012059075,-0.051233113,0.0010325664,-0.07401194,0.06260199,-0.093270294,0.09108114,-0.03446696,0.06834596,0.07120067,0.0057538943,-0.06468328,0.012568943,-0.021946553,0.06273934,0.02985804,0.013165797,-0.045763083,-0.041262686,-0.10863592,-0.08936872,-0.003534428,-0.019250182,0.032254133,0.0124349035,-0.017104195,0.0026616517,0.06873096,-0.05414449,-0.10166786,0.0072548925,0.009107178,0.017327575,0.103972726,0.026174288,0.01770178,0.008481831,0.03682704,-0.0015549184,0.028807508,-0.08157795,0.025243288,0.07047121,-0.070237786,-0.11522191,-0.02399421,-0.028937344,-0.041031472,0.06606099,0.0690247,-0.0077436315,0.057083122,-0.04766156,2.6823362e-34,0.02853189,-0.08960505,-0.015452306,-0.06810906,0.043055426,-0.057858527,-0.06610312,-0.038331397,0.07046179,-0.07683154,-0.10048192,-0.058415666,0.0064275167,0.04653169,0.024227621,0.014248901,-0.02383294,-0.060071263,0.03096394,-0.02726499,0.046558447,0.049527768,-0.017247036,0.013263613,0.06064245,0.02866663,0.0623551,0.06312337,0.024101248,-0.0039872034,-0.04178459,-0.13838285,-0.11602746,0.029936839,0.08999454,0.026865084,-0.052327666,-0.013141957,-0.028226076,0.024002438,0.0008227719,0.00033322425,-0.065398395,0.006743961,0.008988511,-0.06987497,0.022218797,0.1012873,0.008025419,0.089711964,0.03834347,-0.07569522,0.039175533,-0.030403268,-0.0800229,0.03596324,0.012057687,-0.040528603,0.08022042,0.048622236,-0.0033313683,0.0027835974,-0.051085364,0.053792365,0.05730701,0.05785529,0.0043807966,-0.069702394,0.011556793,0.021150459,-0.08812412,-0.07000377,0.053300183,0.02773336,-0.048032112,-0.06303017,-0.029832045,0.022701154,0.012566959,-0.06956202,-0.020522006,-0.021793993,0.033007953,0.05106274,-0.052127365,0.020068532,0.008135227,-0.07715165,0.0034301928,0.0056909183,0.021022951,-0.043468364,-0.08151492,0.040461734,0.03525618,-2.2247536e-33,0.025566366,-0.030056614,0.029163893,-0.019980112,-0.05212343,0.073839165,0.010767107,0.04284604,-0.0059214323,-0.082664356,-0.026061391,0.0954322,0.0026535257,-0.015823632,0.0076876925,-0.0014229444,0.015333483,0.052487362,-0.041861415,-0.027040035,0.065461084,0.05867041,0.024663577,0.02499637,0.04502662,0.0034359205,0.0064760935,0.051180486,-0.0033845745,0.07355381,0.067782514,0.096522175,0.007892988,-0.06925588,-0.08063647,0.03678506,-0.02415133,0.012721438,-0.08272596,0.0072461152,0.012293426,0.102868505,0.033615276,0.051838327,-0.008299352,0.054208044,-0.012485584,-0.0067371493,-0.044715647,-0.07229421,0.02695328,-0.027409052,0.05599996,-0.018644357,0.029178903,0.028841052,0.039322663,-0.00946667,-0.012360054,0.03451872,-0.03962568,-0.098992355,0.031810865,-0.023857223,0.055751245,-0.009105085,0.042158134,0.09708896,-0.017304875,0.009941153,0.06216905,0.007957051,-0.022586716,0.041549888,-0.078751504,-0.059636,-0.07737836,0.032847542,0.091817215,0.040455908,0.0074567003,0.041467857,-0.03898772,-0.043506976,-0.042320874,-0.10370592,0.020179018,0.12498045,-0.0131474,0.05792747,-0.044564117,-0.07653849,-0.046211664,0.027302291,0.021502264,-3.4059493e-08,0.028985092,-0.018869057,0.043870166,-0.00980154,0.04507956,0.016780348,-0.024043616,0.08626582,0.051653396,-0.04466895,-0.01831924,0.0640698,-0.05651934,-0.03702183,-0.042110812,0.06081855,-0.049386267,0.01787745,-0.07264532,0.03813879,-0.034978684,-0.034013007,-0.10864298,0.014840776,0.054711975,-0.026434172,0.07490055,0.08334882,-0.0019707242,-0.0046560233,-0.04555262,0.055607423,0.006482144,-0.09512878,-0.10258959,-0.027002158,0.022653904,-0.06514159,-0.01627,0.05770685,-0.0317886,0.03966576,-0.056222502,0.013898885,-0.011844943,0.05675826,0.008329897,0.02899219,-0.048306946,-0.016827997,0.06801871,-0.043785382,-0.019281393,-0.039386485,-0.15672916,0.00342392,-0.03554303,-0.04751072,-0.06580669,-0.032680288,0.03443716,0.0438539,0.10334021,0.019568704 +2.3.1.313,"The enzyme, a member of the sirtuin family, removes the lipoyl group from the dihydrolipoamide acyltransferase (E2) component of 2-oxo acid dehydrogenase complexes such as EC 1.2.1.104, pyruvate dehydrogenase system. The enzyme often has additional activities and can remove other modifications of lysine residues such as acetyl and biotinyl groups. cf. EC 3.5.1.138, lipoamidase.",384,1.0,-0.10567307,-0.03583511,-0.10241225,-0.01616444,0.09144449,0.02158768,-0.09137405,0.017619185,0.014765558,-0.03037546,0.030094407,-0.04738102,-0.12219236,-0.011283645,0.0051700496,0.02119277,-0.09160311,-0.016109284,-0.0037365828,-0.11636529,0.09597444,0.05538775,0.02207397,0.019590855,-0.0008524531,-0.0040757568,0.0321659,0.06862856,0.0031497318,-0.10516791,0.061007407,-0.08455014,0.084432006,-0.06982516,-0.00600221,0.109289475,0.03494018,0.00039484425,0.04811546,-0.02558761,0.0655382,0.026496287,-0.024786256,-0.043740068,0.037780814,-0.04888498,-0.07902033,0.045149736,0.054657325,0.0161085,0.0068694092,-0.028210118,-0.00736454,0.008241105,-0.026771724,0.01763064,0.026677994,-0.029165559,-0.022233319,-0.024015475,0.030352535,-0.0020160675,0.00608775,0.029776486,-0.073526464,-0.0830108,0.07399651,-0.12906103,0.06469367,-0.019405827,-0.079561,-0.13183205,0.025731636,0.027625943,-0.012301846,0.062385403,-0.081640355,-0.031288605,-0.02484476,0.018682912,0.024044938,-0.08053981,0.04558988,0.10823424,0.0030079256,-0.059274066,-0.018917663,-0.10223874,-0.03788592,-0.028963035,0.0068857423,-0.023973173,0.06454673,0.017492043,0.0016192509,0.04000639,0.05429679,-0.017382123,-0.017173974,0.008251843,-0.0053232526,0.06885926,-0.14242071,-0.06550475,-0.06917226,0.04009913,-0.0016765973,0.024354277,0.007206854,-0.02433901,-0.029421328,-0.027890231,0.045351695,0.035797257,-0.05252214,0.044864845,0.035744812,9.8457116e-05,-0.0436059,0.040835306,0.029262252,-0.0067090173,0.0751874,0.08295763,0.017590012,0.005911441,-0.08702101,4.2587187e-33,0.037416503,-0.002080793,-0.027045717,-0.05276305,0.0080584185,-0.0066699903,-0.11761035,0.05331599,0.03392446,-0.034043666,-0.024771227,-0.09144419,0.058592465,0.0036998342,-0.03776254,-0.007153107,0.027673544,0.011592217,0.07197631,0.012938807,-0.00045713957,0.054577857,0.0050850413,0.037827544,0.018172827,0.11589559,0.010176183,0.026972976,0.02885547,0.018929783,-0.00695718,-0.078926034,-0.08777106,0.045692056,-0.0064880913,0.03923286,-0.019856943,-0.07369869,0.054720264,0.08808813,-0.0057868534,0.0038168773,0.025420427,-0.07864333,0.001936139,-0.03900436,-0.004966237,0.08664346,0.06057115,-0.008138965,-0.027811129,-0.076269254,0.11538242,-0.043677714,-0.009232423,-0.03382712,-0.017804686,0.048756626,0.049183343,0.035016067,0.046486877,0.024991674,-0.057109486,0.04996727,-0.022322433,-0.014902475,-0.0702203,-0.06354891,-0.031412065,0.03897208,-0.02186632,0.04651564,0.10323007,0.017024314,0.039563663,-0.02093922,-0.031888463,0.083530754,0.0075645307,0.04149022,0.037690587,0.033858787,-0.014948617,-0.032797363,0.026198385,-0.04696009,-0.060930517,-0.019814437,0.052752685,0.021128288,-0.042918757,-0.05746168,-0.050528444,0.039286666,-0.0055624167,-5.522901e-33,0.02986484,-0.01767913,0.030161815,-0.058541324,-0.029001242,0.098976955,0.036269024,0.04411331,0.09705292,-0.00063660345,0.06748441,-0.049180686,0.044367895,-0.08325969,0.02765829,0.088026635,-0.04434504,-0.011606708,-0.046245802,-0.013538382,-0.020425132,0.0044645797,0.066907726,0.06617563,0.061199754,0.009211114,-0.061420783,0.023024617,0.0022273457,0.043456484,-0.060905416,-0.013584836,-0.087501965,-0.04616087,-0.04351777,0.048735913,-0.09033292,0.0048981016,-0.010522333,0.05590314,0.027462006,0.04712306,0.027089512,-0.041319437,0.08647655,0.024182048,-0.06953165,0.017916117,-0.01413141,-0.060907457,-0.014662715,0.020802356,0.02012855,0.054205757,0.0367232,0.07645432,0.0693243,0.045459285,0.0034318308,-0.020140827,0.012924717,-0.048846655,-0.032873813,0.09844514,-0.0070942477,0.04095924,0.006706038,0.039542127,0.040460266,0.026695972,0.057259955,-0.052231535,0.054923784,0.05819441,6.490858e-05,0.0047230073,-0.09001669,-0.10329318,-0.07623457,-0.057690896,0.0053239074,-0.013990087,-0.010216666,-0.14838406,-0.00090656866,-0.046011075,-0.019896377,0.08401459,-0.00794865,0.023403006,0.009763661,-0.026725832,-0.06295069,0.026396263,0.07198517,-4.176861e-08,0.08106049,-0.06930986,0.08524966,-0.03488286,0.0055692317,-0.022737082,-0.006077194,0.044646494,0.05359057,-0.04957242,0.021498598,0.08961906,0.024170319,0.00010458984,0.00058836973,0.06316198,0.01576656,0.06720079,0.036025144,-0.053227134,-0.036774285,-0.045853153,-0.05396175,0.00053295837,-0.0031386002,-0.06649996,0.016636828,0.03760335,-0.029701449,-0.035767604,-0.0073968153,0.036200162,0.03396162,-0.023621904,-0.035210617,0.01806197,0.0007661902,-0.028275162,-0.016300587,0.07348493,-0.032193244,0.0115169175,-0.10764894,0.018995013,0.0421492,-0.0036219894,0.033543624,0.03023784,-0.0056148362,-0.022064345,0.009638065,-0.02140587,-0.026531162,-0.049140878,-0.048389655,-0.016841576,-0.040078532,-0.08499862,0.034543674,-0.06695021,0.003503629,-0.0077661863,0.18244657,-0.085193835 +2.3.2.37,"The enzyme, detected in fungal species that belong to the Ascomycota and Basidiomycota phyla and characterized from Aspergillus fumigatus, is bifunctional. The AspRS domain catalyses the transfer of L-aspartate to tRNAAsp (EC 6.1.1.12), while the second domain carries out the transfer of L-aspartate to the 3beta-hydroxyl of ergosterol.",384,1.0,-0.051250223,-0.05472912,-0.17779942,-0.014408606,0.038944308,-0.011070065,-0.0911658,0.072709166,0.01838404,-0.081238866,0.08521104,-0.064505816,-0.085620865,0.013514969,-0.07690391,0.019523086,0.009742349,-0.024629965,-0.004564802,-0.0037146683,0.09231509,0.052886076,-0.032488164,0.037473224,0.049070343,-0.045693446,0.061931115,-0.090821385,-0.046611276,-0.13431413,-0.06137318,0.0025045613,0.03736894,-0.06943419,0.012243315,0.0930874,-0.09718876,-0.07489669,0.077105284,-0.02986603,0.060559474,-0.054741446,0.010325968,-0.054907493,-0.068922035,-0.018797072,-0.0056213657,0.102877356,0.06708481,0.009903811,0.010637952,0.018610543,-0.050409406,0.013277594,-0.117768124,0.08845829,-0.036884908,-0.053437904,-0.055955306,0.039119624,-0.021975776,0.040209096,-0.011919867,-0.0070489678,0.026209254,-0.06145494,0.01416945,-0.019063232,-0.026594222,0.005571529,-0.05678539,-0.06228428,-0.009402672,0.065251894,0.15250185,0.07327302,-0.049041156,-0.008042221,0.0098820925,-0.026196657,0.0987468,0.0007853086,-0.0018079489,0.048850946,0.03502161,-0.028092211,-0.038852625,0.049361836,0.032404725,0.047884937,0.04991122,-0.017294824,0.0033970503,0.016723305,-0.06457037,0.08545076,0.07313321,0.050303753,0.03152882,-0.06410997,-0.028772589,0.019077022,0.003445777,-0.044526994,0.0013436067,-0.061505053,0.012002037,0.027318174,0.09788721,-0.043433502,0.025569728,-0.057422627,0.0778312,-0.07612421,0.0154395625,0.0051763104,-0.0061159935,-0.04957931,-0.019354474,-0.061456975,0.018924644,0.029309295,-0.022719989,-0.005663582,0.03972129,0.06748369,-0.054208107,1.7396058e-33,0.06332662,0.022559544,-0.02600988,0.008324064,0.016022798,0.023102446,-0.040350698,-0.050661925,-0.061253987,-0.050961975,-0.08695806,-0.041647613,-0.03391181,0.0025784883,-0.04783754,0.0020213013,0.018684473,0.0101994695,0.0744525,0.037225626,0.0027953926,0.10795272,-0.061915085,0.014909143,0.027413165,0.0357523,-0.03780092,0.05477233,-0.0088248355,-0.008855512,0.033240806,-0.039555773,-0.16323482,0.014898512,0.12579656,-0.0043645115,0.0122675495,-0.061861996,-0.0544747,-0.019040287,0.0040075686,0.06623398,-0.046864375,0.0065394435,-0.013780436,-0.013342052,-0.039832342,0.037508447,0.06412878,0.067294836,0.045673825,-0.004827876,0.08960819,0.015504464,0.033611827,0.024660375,-0.067561075,0.048412386,0.031508617,0.07607178,0.024912352,0.07897216,-0.042188823,0.037020907,-0.041162796,0.02738524,-0.06403338,-0.032737352,0.027526077,0.0060604196,-0.058499478,0.01926586,-0.010116243,0.017118605,-0.01312527,-0.033400107,-0.05123834,0.006763977,-0.0233486,0.0011805324,-0.024632247,0.0035829954,0.026035788,-0.037668396,-0.04716794,0.048419703,0.036469676,-0.048495032,0.0026350014,-0.02055911,-0.02385186,0.002606099,-0.03473441,0.034803618,0.11624245,-4.387315e-33,0.07681042,-0.12850873,0.0689888,-0.026393065,-0.076473035,0.06226844,0.066473834,-0.05619731,0.010216101,0.004197108,0.04907211,0.09012877,0.005792897,-0.019574068,0.07416368,0.01618345,0.03650828,0.0555722,-0.016621623,-0.051842898,-0.053991776,0.10385291,-0.015069036,0.119203836,0.01485116,-0.02637253,0.017810676,0.004126619,-0.021849468,0.02813203,0.03353075,0.026711758,-0.026190065,-0.005303576,-0.11014971,0.025265248,-0.018898262,0.021757243,-0.0044330084,0.00092684163,0.027620427,0.0046317824,-0.026564617,0.017970158,0.018779505,0.022929296,-0.040717952,0.050374467,0.038826562,-0.0600446,0.006406638,0.011964978,0.030252177,-0.022309316,0.0026631048,0.001499543,0.04775007,-0.010981339,0.056003403,-0.07382682,-0.06872267,-0.012830048,-0.023666201,-0.014252054,0.024345573,0.045544412,0.012023184,-0.06318026,0.082242996,-0.0019613865,0.02520592,0.038716726,-0.03403119,0.022318749,0.010668438,-0.060678076,-0.02536039,0.016750775,0.008998136,-0.009818369,-0.010515153,-0.045225132,0.07126898,-0.07237808,-0.050915007,-0.1250189,0.03814909,0.061109126,-0.03883254,0.039459564,0.0324287,-0.026833076,-0.027627207,-0.016227761,0.09933162,-3.788928e-08,0.022367295,0.05355483,0.021298094,-0.08248996,-0.037669368,0.027701497,-0.033073034,-0.024810622,0.07614416,0.0059820595,-0.086626686,0.07693221,-0.013877288,0.0014709651,0.0788338,-0.018641453,-0.013508667,0.09775906,-0.011435952,0.020321628,-0.026857961,-0.0061868182,-0.13399069,-0.001872876,0.006987433,-0.036021147,0.018737825,-0.033073526,0.08888035,0.023022572,0.024681136,0.01352054,0.06432677,-0.031396456,-0.0064112474,-0.025417442,0.027437482,-0.055752832,-0.005114864,0.06791322,-0.0024051587,-0.04118005,-0.057236046,-0.043536227,-0.15118046,0.0364974,0.05862374,0.06924435,-0.014762289,0.040646024,0.019510234,-0.050947558,0.006077045,-0.015617687,-0.033546202,-0.049966406,-0.01095181,-0.075033784,-0.047660794,-0.04571362,-0.019333914,0.02952742,0.1362609,-0.025865452 +2.4.1.393,"The enzyme, present in mycobacterial species that produce a 3-O-methylmannose polysaccharide (MMP), is involved in recycling and biosynthesis of the polymer. The enzyme has the highest activity with 3-O-methylated mannosides with 4-6 residues. The residue at the reducing end of the substrate is often dimethylated, with the second methyl group attached at the O-1 position.",384,0.99999994,0.0083240485,-0.056103136,-0.029638136,-0.068563424,-0.020521665,0.00072631077,0.037075616,0.07363696,0.017918216,0.06494212,0.011366111,-0.012635447,-0.019701364,0.04023736,-0.0761555,0.096265845,0.026144471,0.03224543,0.037710086,0.012799987,0.10909483,-0.02014222,0.02855591,-0.064342014,0.08663598,0.032615464,0.040562168,-0.019806284,0.0017277389,-0.08124667,-0.03654466,-0.007243598,0.0795398,-0.0821295,0.14026468,0.118449524,0.009887003,-0.06691757,0.063809186,0.0017284907,0.06277924,-0.022883888,0.04556464,-0.065829046,-0.042473283,0.009228998,-0.06779011,0.050870698,-0.04625386,-0.0075335866,-0.042288296,-0.05508343,-0.02572465,0.0037741684,0.023612523,-0.04392141,-0.016896674,-0.02180908,0.0019246165,0.02829629,0.019138116,0.01193523,0.015216909,0.023994325,0.04866394,-0.057954524,0.0030795275,-0.044902727,-0.01139806,0.021565555,-0.08133613,-0.014676408,-0.0759559,0.02252968,0.069234945,-0.07050945,0.024510954,-0.0848932,0.06167428,0.049297776,-0.016962212,-0.0002824172,0.013680678,-0.02952595,0.008460058,-0.046075474,0.069481425,0.034521427,0.047776233,0.025858367,-0.034991655,-0.0005680521,0.005335356,-0.016987713,-0.047302663,-0.034235477,0.027139246,0.028827459,0.061392292,-0.0047857207,0.025323756,0.001487261,-0.006715907,-0.06958382,-0.04194841,0.004898026,-0.0061338646,0.03471684,0.08551495,0.070578866,-0.03185152,0.07573401,-0.035088222,-0.027705127,-0.024101174,0.09303912,0.09829939,-0.06312272,-0.043529626,-0.0022259539,-0.025492564,-0.089020066,0.03561769,0.00757626,-0.07465135,0.055093296,-0.01755546,-9.083075e-34,0.00933249,-0.047302663,0.053536292,-0.04443913,0.08256761,-0.0310764,-0.021077536,-0.049106665,-0.06653046,-0.059580527,-0.112390146,-0.090139,-0.0021114764,0.10271868,-0.08959281,0.018464541,-0.029232215,0.019241387,0.06760119,0.010299812,-0.015084096,0.036617305,0.016077366,0.044983078,0.07709848,0.044061955,-0.029889198,0.033747204,0.03379159,-0.0092297215,0.08736408,-0.062172923,-0.1433634,-0.058328506,0.0061723217,0.03410578,-0.08797842,-0.065218806,0.032446057,0.051426113,-0.006467605,0.020917568,0.06516126,-0.03655896,0.019439314,-0.014041729,-0.021033997,0.016693508,-0.03978717,0.033913773,0.058175452,-0.022324387,0.019180352,-0.018687414,-0.045180634,-0.009870848,-0.048239976,0.007564026,-0.0023033335,0.069719575,0.03761112,0.004362937,0.009254466,0.06193694,0.0043526078,-0.042688668,-0.0004151969,0.046677183,0.07438666,0.032166198,-0.032415885,-0.04849656,0.019858902,-0.04941164,0.031841133,-0.027257163,-0.05668536,-0.0020576208,0.024111714,-0.028350359,0.071817316,0.026901446,-0.039888937,-0.089941554,-0.0721013,-0.011353784,-0.055649146,-0.09014368,-0.0063724006,0.017032461,0.02088659,-0.04698046,-0.026031699,0.07326853,-0.050524805,-2.3278449e-33,0.12594548,-0.10949407,0.12121368,-0.058378827,-0.062300928,-0.059633728,0.07948592,0.026691958,-0.018596087,0.0050908495,0.09497601,-0.029457172,0.040154975,-0.0023060467,0.025740065,0.018880244,-0.0034838421,0.09308487,-0.026202645,-0.013072334,-0.029709497,0.097024135,0.03543635,0.01622664,-0.019012118,0.007209841,-0.08850237,0.00040511382,0.045072332,0.027082484,-0.013994165,0.0066865142,-0.037135627,-0.073024064,0.0074065803,-0.025386658,-0.095771715,-0.035430465,0.060576636,0.034032345,0.0010897025,0.078281246,-0.0301141,0.022854146,-0.008122546,-0.00022970213,-0.07254515,3.3464563e-05,0.035200175,-0.044810116,-0.06991686,-0.06481735,0.03138859,0.015127842,0.040668942,0.086529866,0.027497172,0.0036531861,0.0070009236,-0.045625467,-0.083624445,-0.0069887824,0.05665695,0.007215091,0.08909753,0.15719719,-0.019872537,-0.0073880553,0.01786364,-0.051604364,0.026838712,0.03794732,-0.037763778,0.009677353,-0.03963441,-0.07079521,-0.07811835,0.047301937,-0.041502696,-0.046964854,-0.03575405,-0.049094573,-0.031111585,-0.06727677,-0.05092335,-0.104363754,0.05851709,0.05567882,-0.036165085,0.058855854,-0.02244074,0.07873914,-0.057935424,0.052927542,0.02383987,-3.8546105e-08,-0.0066788183,-0.061890636,0.01288056,-0.04957606,0.010205952,0.04876401,-0.059675645,-0.0018350285,0.03827322,0.03604057,0.056998625,0.0768666,-0.010593175,-0.009515677,0.057085685,-0.009113643,-0.0760484,-0.062870994,-0.007654632,-0.07345386,-0.10100121,0.04959493,0.011900846,0.0652857,0.008429275,0.017551955,0.041018035,0.11921016,0.028616518,0.0076987436,0.012906613,0.11641276,-0.024029622,-0.05897097,-0.09576994,0.017631434,-0.061929706,-0.077076145,0.0031879304,0.025897395,0.05143344,-0.02044789,-0.015438048,0.00066814444,0.009877338,0.054767475,-0.05258453,0.029630296,-0.0732578,0.059889156,-0.029195862,-0.007895651,-0.07090629,0.030512549,-0.032973193,0.015138216,-0.07303615,-0.0058258767,-0.005910333,-0.05309481,0.04512174,-0.046437707,0.12317062,-0.07004423 +2.4.99.26,"This Gram-negative bacterial enzyme attaches the polymerized O antigen molecule to the outer core region of the lipid A-core oligosaccharide, finalizing the biosynthesis of the lipopolysaccharide. Prior to the reaction the two substrates are attached to the periplasmic-facing side of the inner membrane, and the enzyme transfers the O-antigen from its polyprenyl diphosphate membrane anchor (usually ditrans,octacis-undecaprenyl diphosphate) to a terminal sugar of the lipid A-core oligosaccharide. Despite the popular name ""ligase"", the enzyme is not a real ligase, as the reaction does not involve the hydrolysis of a phosphate bond in a triphosphate. The enzyme is embedded in the inner membrane and often has 12 trans-membrane segments. It is a metal-independent inverting glycosyltransferase, and in some cases it can attach surface polymers other than O-antigens to the lipid A-core oligosaccharide.",384,0.99999994,-0.06760084,-0.100843154,-0.053967774,-0.01282808,-0.06368617,-0.056007035,-0.03983288,0.08632055,0.08490414,0.015496965,0.06220318,0.009963407,-0.03736071,0.05458547,-0.06667351,-0.018836232,-0.024513045,0.0072121387,-0.030187652,-0.014478898,0.09926135,-0.025929108,-0.06275068,-0.06700133,0.033531692,-0.036108505,0.039255556,-0.06255168,0.001405973,-0.053045243,-0.04669787,-0.100921236,-0.028046548,-0.07033566,0.060136016,0.050291035,0.016795084,0.016318537,0.01440725,-0.036506142,0.042963155,-0.03722782,0.011299849,-0.017174523,-0.0094641065,-0.03030781,0.0077826018,0.045842867,0.009059293,-0.016710557,-0.040266003,-0.06749577,-0.033517838,0.030662885,0.009869894,0.056448225,-0.044623464,-0.0056080003,0.008658719,0.055898402,0.013100466,-0.0012492564,0.015466126,0.014047691,-0.004893562,-0.12274022,0.13103272,-0.052347545,-0.017325336,-0.011785036,-0.024632307,-0.053460285,0.020957047,0.013388594,0.040756002,0.0530986,0.0046030614,-0.009460382,0.07127537,0.018571183,0.08734517,0.021408347,0.04963277,0.12716015,0.0077022007,-0.017146712,0.003774764,0.0032939466,0.008886001,0.05555752,-0.037198618,-0.02187894,0.014957227,-0.08148345,-0.0650922,-0.030611774,-0.0036813566,0.040043615,0.03743645,-0.02163301,-0.019375527,-0.0077001266,-0.01695163,-0.07785547,-0.069538854,0.051611457,-0.05100887,0.07079563,0.04616377,0.011571948,-0.0064152814,0.03770474,0.060617242,-0.061806846,-0.10108848,0.058912095,0.01714658,-0.04348146,0.03870937,0.035411578,-0.05052507,-0.028977824,0.0138998255,0.07138793,-0.009105631,0.06273353,-0.07031663,2.1142274e-33,0.036097657,0.0017095613,0.02397864,-0.06293982,-0.041889306,-0.011624241,-0.039422773,-0.0018165887,-0.11303846,-0.0016997443,0.004720341,-0.11176799,0.028481234,0.06994567,0.030852873,0.007442357,-0.0066817934,-0.016001903,-0.023663642,0.026208293,-0.014000248,0.0808244,0.0002682559,-0.010097688,0.12072308,-0.0071958797,-0.06685179,-0.007931224,0.012159225,-0.00041261644,0.02460033,-0.06489164,-0.08334177,0.020101523,0.10368597,-0.03177744,0.0075576846,-0.051543757,-0.03674325,0.008820103,-0.031684868,0.040343855,-0.060570877,0.0006403497,0.03515503,-0.03775791,-0.022738526,0.031003693,0.009278438,0.034294553,0.10894812,-0.010156598,0.033658143,0.02047356,-0.05187891,0.032779943,-0.068329394,-0.030493492,0.040099744,0.026372332,0.008689614,0.008164266,-0.06992098,-0.026820624,0.0069053653,0.048922822,-0.034808416,-0.052008603,0.045179795,0.019015107,-0.053393424,-0.017293805,-0.025451891,0.048212726,-0.020749906,-0.011082565,-0.005507535,0.032593295,0.078272045,-0.02320285,0.08649982,0.027369335,0.057639413,-0.04573043,-0.008699511,0.002639933,-0.0021812834,-0.079613455,-0.063020624,0.02164851,0.06216575,-0.064871766,-0.061491836,0.062972516,-0.005342986,-4.9065667e-33,0.03280027,-0.1239823,0.05355063,-0.10717122,-0.077295944,0.055753227,0.030505909,0.0028466259,0.032027576,-0.07258226,0.05476251,0.0016629301,0.03670961,0.05967771,-0.020379217,-0.0069871773,-0.08870795,0.07743758,-0.0006372161,-0.0139122605,-0.010310359,0.06787959,0.09020599,0.034851935,0.06723006,-0.027565233,-0.03335239,0.07497123,-0.037584215,0.09461332,0.008045737,0.018327516,-0.040425036,-0.024835384,-0.073954575,0.027559288,-0.06318409,-0.059180763,0.07518039,-0.0064290706,-0.01921086,0.019825352,0.05446227,0.004964713,-0.05884996,0.056455806,-0.061405167,0.021085827,-0.007225984,-0.04660891,-0.014521084,0.015420807,0.03316439,0.076254174,0.0015134445,0.04536978,0.07334034,0.014989168,-0.00076153467,-0.05407256,-0.017965082,-0.06388714,0.05903023,-0.0010215938,0.10030378,0.11043221,0.04666436,-0.031877577,-0.014118868,-0.10987675,0.015705511,0.061611045,-0.04713872,0.0377811,0.0240506,-0.016356118,-0.08198968,-0.056559812,-0.03802378,0.031849846,-0.035299335,0.00854973,0.007915695,-0.054730594,0.11574136,-0.057974517,0.07944536,0.11936841,0.016179923,0.07152431,-0.008618156,0.0058146855,-0.024885729,0.041641742,0.09471362,-5.1131387e-08,0.07663354,-0.051738728,-0.022393735,-0.10371924,-0.06565667,0.04490849,-0.015497109,-0.08173969,-0.00064277765,-0.00342879,0.024135647,0.1282634,-0.0749929,0.0021294686,0.023488909,0.020060405,-0.044993263,-0.020779358,-0.007870403,-0.031131005,-0.07958708,-0.01112241,-0.09086651,0.0793039,-0.0073691234,-0.07816075,0.034846053,0.066491656,-0.022957055,-0.03362721,-0.030819863,0.041290656,-0.019133093,-0.056897182,-0.090348534,0.044691462,-0.010769807,-0.03283247,-0.037749156,0.03719463,0.0705331,-0.0070027686,-0.029594667,-0.009153411,0.054675344,0.06039652,0.0028461132,0.05921247,-0.07372973,0.06062603,0.05116319,-0.016524715,-0.034947116,-0.033366386,-0.12342259,-0.088629164,-0.050154634,-0.016018324,0.012302697,0.015776562,-0.0051260637,0.025030097,0.17181078,-0.058156785 +2.4.99.27,"The Wzy-type polymerase polymerizes O antigen repeat unit oligosaccharides that are anchored to the periplasmic face of the inner membrane, forming an O antigen polysaccharide that is still anchored to the membrane. A Wzz chain length regulator (sometimes referred to as an O-antigen co-polymerase) normally interacts with Wzy to confer a distinctive modal chain length distribution. The resultant polysaccharide is transferred from the membrane anchor to the lipid A-core oligosaccharide by EC 2.4.99.26, O-antigen ligase, forming a complete lipopolysaccharide structure. There is an enormous diversity of O antigen polymerases with different specificities, reflecting the variability in the structure and composition of O-antigens.",384,1.0,-0.046842184,-0.053288154,-0.026504545,-0.021243062,-0.032006964,0.0006010177,0.010264278,0.0488819,0.08061707,-0.03400291,0.02282521,0.04677684,-0.048939448,0.034822132,-0.049866628,0.06004269,-0.056006562,0.012984617,-0.025559824,-0.055564955,0.1037988,-0.038851522,0.01127474,0.0003264355,-0.056589797,-0.026540913,-0.015518958,-0.007472209,0.01724995,-0.09591507,-0.05211475,-0.10985411,0.031779494,-0.063637026,0.03847947,-0.01839715,0.042435903,-0.014994508,-0.044062596,-0.001063235,0.081099674,0.026321586,0.0030857604,0.021624612,-0.07818081,-0.03530012,-0.027730875,0.052362584,-0.027468262,0.053953573,-0.047618795,-0.16270974,-0.04269466,0.021631904,0.027860308,0.044358905,-0.049546823,-0.011094151,0.06560883,0.024865692,-0.043013908,-0.012815087,0.06309568,0.07791858,0.024521338,-0.0510943,0.11429271,-0.021046026,-0.060817048,-0.020198189,-0.06225594,0.0010001726,-0.05453728,0.036960017,0.05510013,0.008232652,0.0069446876,-0.027443942,0.08797474,0.049506154,0.030659124,0.026772322,0.026403084,0.075733155,0.02930873,-0.023016777,-0.01135566,-0.026746122,0.0034014278,0.0017432456,-0.025211705,-0.10312659,0.004919693,0.0023050378,-0.02806555,-0.0430791,0.06886117,0.031887986,0.065909036,-0.026900303,-0.027477061,-0.09081982,0.08644148,-0.040142626,-0.013652893,-0.018051729,-0.011265319,0.031581458,-0.006312135,0.014897087,-0.023609303,-0.02121005,0.08269178,-0.008208418,-0.04212452,-0.009907693,-0.037342776,0.0087173125,0.012230349,-0.0065269214,0.028112212,-0.030570269,0.04124169,0.045507148,0.0077090417,0.08882326,0.008836355,1.0615555e-33,0.06754926,-0.0010111879,0.011079598,0.023751061,-0.014941565,0.000979583,0.015308732,-0.008809331,-0.09984428,0.02893903,-0.016331553,-0.108341224,0.019664623,0.101767346,0.02494491,-0.021430066,-0.004061243,0.02049804,-0.06360642,0.048563354,-0.0041402783,0.055813372,0.006984082,0.036326043,0.07347135,-0.014021182,-0.100743875,0.010056797,0.023361705,0.00020264345,0.044550635,-0.060854282,-0.10830884,0.02477505,0.088595875,0.024537923,-0.025382506,-0.07842899,0.036414586,-0.057313543,0.0033548616,-0.023554986,-0.038801268,-0.024715705,0.05172539,-0.053154737,-0.06117541,-0.030918373,-0.062102072,0.05007743,0.05278048,0.017501554,0.014888902,0.012217679,-0.046995685,-0.028816575,-0.062201675,0.004014891,0.0025214604,0.060343046,-0.042066883,0.07155112,-0.03594214,-0.035489205,0.008841931,0.04676347,-0.04638962,-0.030636536,0.012497964,0.03997937,0.07067057,-0.086314656,-0.044747166,0.071486205,-0.017470917,-0.050205022,-0.008709525,-0.006208615,0.0301245,-0.0143670365,0.07664953,0.04083172,0.04033242,-0.02822958,-0.07795083,-0.04130448,0.018083768,-0.03825778,-0.029045168,0.06311325,0.033170104,-0.031988285,0.028693536,0.08381736,0.013119201,-3.271048e-33,0.037762884,-0.09575785,0.15038326,-0.085689016,-0.07135633,0.04639759,0.04230834,0.064704396,0.025481021,-0.060261287,0.09130321,0.0077658645,0.011746494,0.028871262,0.017565824,0.020921832,-0.11232486,0.054500517,-0.019139903,-0.04800974,-0.022313284,-0.025410417,0.06718615,0.06449883,0.04886144,0.013219181,-0.001582853,0.033881694,0.027326453,0.04845911,-0.046632018,-0.036764223,-0.046679884,0.017547186,-0.04701355,-0.015152234,-0.01731193,-0.0060116802,0.048171774,0.015976505,-0.056685083,-0.017749522,0.07202363,-0.042131092,0.0043914854,0.120207526,0.019368848,0.00058540277,-0.008540048,-0.0075384537,-0.01589103,0.043891404,-0.012278442,0.05764826,-0.043171056,0.04485196,0.06269595,-0.0027115557,0.014082439,-0.1123904,-0.058879953,-0.035581462,0.06088324,0.061356425,0.04893283,0.045352977,0.08573763,-0.04392823,-0.0030391263,-0.10099172,-0.01720316,0.05915856,-0.016680568,-0.020845119,0.031765845,0.0095826145,-0.10206786,-0.03215265,-0.021388631,-0.007641918,-0.055690303,-0.035806436,0.07911606,-0.043202765,0.09232922,-0.050516624,0.07622749,0.048223037,0.03612938,0.10900691,-0.0141082145,-0.015551535,-0.03015637,0.016429266,0.11777685,-4.162399e-08,0.05841368,-0.04587242,-0.013741252,-0.088674895,-0.037814744,0.04518964,0.014851747,-0.04062437,-0.011890715,0.05745929,0.035848327,0.13609062,-0.028237069,0.014279119,0.0019317974,-0.009522747,-0.077420555,-0.03215703,0.015737016,-0.036273003,-0.062176015,0.010134034,-0.059827223,0.0856539,-0.08022718,-0.029358905,0.0032459449,0.090520054,-0.029650377,-0.05451935,-0.007013168,0.08089707,-0.019389857,-0.083680384,-0.078331456,-0.008731239,0.0425366,-0.055691775,-0.037163153,0.082689576,0.042125773,-0.04930561,0.022394273,-0.044409864,0.0422344,0.031274773,0.007221057,0.027342554,-0.07226686,0.061011832,0.04553473,-0.04790148,-0.032571275,-0.05405021,-0.09892339,-0.073914774,-0.023392113,-0.033194162,-0.010120963,-0.026963359,-0.039317515,-0.03987731,0.20744435,-0.0864856 +2.5.1.157,"The enzyme, found in all eukaryotes and some archaea, catalyses the final step in production of the modified rRNA nucleotide N1-methyl-N3-[(3S)-aminocarboxypropyl]-pseudouridine (m1acp3psi). This modified nucleotide is present in the small subunit of ribosomal RNA (18S in eukaryotes and 16S in archaea). cf. EC 2.5.1.114, tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase, and EC 2.5.1.108, 2-(3-amino-3-carboxypropyl)histidine synthase.",384,0.99999994,-0.0096826665,0.0022214104,-0.14926985,-0.08733053,0.025080603,0.019482115,-0.09747401,-0.006423135,0.0013732656,0.009972701,-0.012024885,-0.038045462,-0.01891274,0.04251875,-0.046755012,-0.037263308,-0.12214506,-0.00041780225,0.055142812,-0.023435652,0.011738494,0.13233602,-0.031671006,0.022710834,-0.005512532,0.042166542,0.109032184,-0.082827754,-0.06742624,0.024077235,-0.031488664,-0.12716903,0.12854645,-0.066773824,0.10749695,0.07696874,-0.07929964,-0.014925252,0.10359245,0.037269954,0.03590298,0.057553217,0.04187146,-0.03339843,-0.01817199,0.05348253,0.051340062,0.015823755,0.023887921,0.023968259,-0.00465829,-0.015550009,-0.01580116,-0.045079578,0.007951665,0.04558375,-0.03830816,-0.06545556,-0.02971987,-0.033197697,0.03814555,-0.04364797,0.032046676,-0.06014159,0.06383893,-0.013825019,0.071003,-0.0358974,0.04483201,-0.009674816,-0.023386635,-0.017732123,-0.040804744,0.08629852,-0.015060718,-0.012684213,0.023872308,-0.018221658,0.026198981,0.025888694,-0.04907083,-0.052412003,-0.027624156,0.004243588,-0.0072453655,0.031121919,0.03026983,0.06293703,0.05180144,0.015135922,0.064704016,-0.007247352,0.038329083,-0.04034487,-0.075262226,0.014621969,-0.045792326,0.097332835,0.0012533853,-0.07314767,0.054166216,0.024186973,-0.05203705,-0.061014872,-0.0035425203,0.032039076,-0.010703995,0.10383755,-0.029675443,0.10097913,0.011525847,-0.0034406958,-0.0060847183,-0.044924248,-0.009591846,0.088700384,0.0015969214,-0.07876786,-0.040316604,0.039946735,-0.009476329,-0.0022411952,0.074159905,0.09388524,-0.025105236,0.005995747,-0.094466396,3.2807783e-33,0.013751058,0.04723045,0.007360267,-0.014191156,0.037237562,0.052253127,-0.042938903,-0.009366188,0.0075875367,-0.08067774,-0.08668295,-0.053805828,0.06746985,-0.06921068,-0.06525366,-0.03426135,-0.010609457,0.009344162,-0.021867838,-0.010789858,-0.028386855,0.09699453,0.050199345,0.01827697,0.033556346,-0.0067540635,0.031044204,-0.06057001,0.11990354,-0.042380754,0.015912337,-0.07072288,-0.14233252,-0.0072795437,0.06867245,-0.012354161,-0.00011614123,-0.06255448,-0.040829115,0.14333127,0.014671545,0.016511887,0.023949876,-0.0070766998,0.051951803,0.0060937423,-0.0033727875,0.056986563,-0.073120244,0.02184932,0.009377595,-0.014324068,0.06980511,-0.021719424,-0.044346992,-0.021731094,-0.041744247,-0.03509663,0.087953836,0.026114002,0.021638727,0.00097103254,0.038623545,0.0320541,-0.015776476,0.023132103,-0.047532022,-0.060406584,0.045788944,0.035352066,-0.0006820509,-0.054186378,0.07395373,0.031677853,0.010489096,-0.041505408,-0.12169363,0.013354761,-0.0466431,0.014185493,-0.050969604,0.03199873,0.019123415,-0.003847923,0.014724546,0.02428941,0.036876433,-0.061180245,0.02573901,0.033923108,0.0365648,-0.057535123,-0.058205407,0.020923968,0.0032658214,-3.7598565e-33,0.08370863,-0.14216262,-0.014881161,-0.036440387,-0.0794375,0.0027644623,-0.03363366,-0.031844363,0.028671661,-0.09633447,0.05187784,-0.017932562,0.04852663,-0.060895488,0.03078197,-0.05354748,0.10677372,0.06368593,-0.0156097915,0.0028710063,0.074575275,-0.0074818777,-0.048664737,0.052515484,-0.023103891,-0.02687863,0.015561503,0.070863955,0.08159991,0.014507407,-0.007977887,0.058084615,-0.025542488,-0.01242824,-0.034599036,0.06039808,-0.018705875,0.004584681,0.03885616,0.027952008,-0.00060383294,0.061607104,-0.03769645,0.040192842,-0.027646506,0.06843394,-0.023631474,0.035438772,-0.020894,-0.06269617,0.03746233,-0.09054293,0.04345225,-0.008074597,0.06743633,-0.009101829,-0.04013391,0.07174455,0.071530454,0.005740353,-0.014670075,-0.061471157,0.029626552,-0.03766513,-0.0074874563,0.039938122,-0.06797217,0.016264288,0.019781036,0.0117327925,-0.030109702,-0.015778704,0.032274496,0.066190355,-0.021327702,-0.028223947,-0.021857014,-0.021302128,0.07011085,-0.070674986,-0.026891243,-0.0538438,0.05413417,-0.005564964,0.025272202,-0.0726048,0.10468992,0.07343401,-0.08029135,0.024495857,0.010036591,-0.06866541,-0.00674354,0.04813839,0.03323684,-4.1999705e-08,0.06535649,-4.8308535e-05,0.013006608,-0.01976671,0.020746712,0.060549647,-0.0016332305,-0.0026489545,0.037479345,-0.055686753,0.021575902,-0.040900815,-0.016738357,-0.017818803,0.010730031,0.08353026,-0.0972373,0.018283328,0.004155775,-0.012882338,-0.06794824,0.070696004,-0.113881394,-0.04442961,0.007920198,0.05719202,0.0474948,0.02446947,0.01105545,-0.09560117,-0.025966218,-0.01122097,0.09060553,-0.021112422,-0.04756788,-0.023826515,0.033400483,0.019329738,0.035135783,-0.018873544,-0.0120005235,-0.027701901,-0.056298558,-0.021021837,-0.064243995,-0.004794492,-0.018060323,0.066252075,-0.097307205,-0.024207538,0.069612324,0.052778855,0.063319035,-0.04517606,-0.0012423666,-0.022204734,-0.055693947,-0.121461265,-0.08589998,0.07390092,0.0063645374,-0.031468578,0.11341201,-0.001662704 +2.7.11.35,"Requires Mg2+. Peptide array data show a preference for phosphorylation of Thr over Ser and a preference for basic residues in the -5 to -1 positions [1]. CRIK is an animal-specific protein kinase that phosphorylates myosin light chain (cf. EC 2.7.11.18, myosin-light-chain kinase) and is involved in cytokinesis in both mammals and Drosophila. Human CRIK phosphorylates myosin light chain, MYL9/MRLC1 on T19/S20 [2] and GLI2 on S149 [3]. Drosophila CRIK (sticky) interacts with the kinesins Nebbish and Pavarotti, and human CRIK interacts with their orthologs, KIF14 and KIF23/MKLP1 to promote midbody formation during cytokinesis [4]. In Drosophila, CRIK/Sticky catalytic activity was required for this function. Human CRIK is mostly highly expressed in brain, and mutations that alter splicing or kinase activity lead to microcephaly [5, 6], as do knockouts in mouse and rat, and mutations in its interacting partner, the kinesin KIF14 [6]. ",384,0.99999994,-0.11810602,-0.06921046,0.032522686,0.008458725,0.05407431,-0.008311341,0.076563805,0.044405494,0.012697786,0.049995765,-0.0016463008,-0.008704515,0.0024241328,0.08547248,0.014728889,0.107158735,-0.033326108,0.057327613,-0.022816144,-0.056319576,0.06950512,-0.016062304,-0.031681735,0.019681571,-0.086419486,-0.01535852,0.05252766,0.036499206,0.024168836,-0.05478708,-0.052599847,-0.0058647646,-0.017124398,0.040413037,-0.04620779,0.09697638,-0.06251757,-0.04820221,-0.023270736,-0.06207341,0.088750124,-0.036289386,0.04757403,-0.05646717,0.04128303,-0.0060134265,0.00027156953,0.017328884,-0.03912443,0.035719827,-0.043783147,-0.047074854,0.026252754,0.08608502,0.077710375,0.08486309,-0.13411316,0.009165052,0.072930425,-0.03959447,-0.056614093,-0.03476144,0.06718402,-0.03509998,0.04270252,0.0006928754,-0.076210134,-0.03204078,-0.0030877555,0.028476987,0.016777223,0.019214528,-0.014303602,0.024481488,0.0037508418,0.054554284,-0.00773936,-0.0053517227,-0.05944134,-0.018768312,0.0001530852,0.030213743,0.08341557,0.046369042,0.06711666,0.015016689,0.06293458,0.06025284,-0.054243468,0.065707594,0.06806664,-0.0053722765,0.048643608,-0.01635416,0.064277224,0.054959957,0.021119146,0.006053756,-0.012893096,-7.476328e-05,-0.0073915287,0.03390095,-0.06328869,0.00758322,-0.010268514,-0.011549189,0.002229355,0.012841062,-0.026467072,0.048527945,0.043323282,0.020058213,0.031090783,0.012188504,0.008478302,-0.011581774,-0.07800128,0.05301141,0.09984662,0.041322026,0.03004038,-0.00856618,-0.11630153,-0.0104442155,-0.03858109,0.009613362,-0.13039191,4.541294e-33,-0.0069247982,0.014964976,0.017051488,-0.011201397,-0.03617508,-0.0948838,-0.06031538,-0.066446885,-0.06189584,-0.08825204,-0.042340968,0.04096575,-0.0075072716,0.029596504,-0.08539525,-0.057898,-0.00069091487,-0.07120951,0.06651951,0.038496602,-0.045071095,-0.005693633,-0.051824264,-0.103696026,-0.06022305,0.042628936,-0.046069533,-0.0013410848,-0.0095599005,0.011597116,0.0026739144,0.020762658,0.0111018615,0.08048338,0.013079565,-0.028038526,-0.009692058,-0.12993556,-0.07659716,-0.021276107,0.018529546,-0.009582218,-0.12926409,-0.029298322,0.066743046,-0.06077593,0.0008238808,0.051291585,-0.02242615,-0.012576682,0.07095176,-0.0013551463,0.06225904,-0.09041548,-0.067642696,-0.08912723,-0.0406434,-0.0690213,-0.017361423,0.05284764,-0.038477525,-0.040559854,0.040250693,0.055045623,0.09338652,0.009008485,-0.08570012,-0.023555288,-0.02425607,0.016059449,0.08171695,0.031209892,0.052135505,-0.03867597,0.028179282,-0.006710644,0.057279095,0.048981894,-0.11322166,0.13149588,0.051629327,-0.017030766,-0.04112311,-0.027391333,-0.01003708,-0.059693698,0.023654971,-0.028561367,-0.019642077,-0.039799176,0.045477256,-0.066547066,0.033583187,0.08267395,-0.05746371,-5.67326e-33,-0.024777174,-0.060377,0.0921482,-0.001138281,-0.06929962,0.0681599,0.08869274,-0.06846797,0.029424379,-0.016944565,0.070718,-0.009162731,-0.06381077,-0.040999632,0.018782943,-0.016907264,-0.038664617,0.048774917,0.019457571,-0.030185033,-0.028056227,0.14437787,-0.008122649,0.11490075,0.033516396,0.066285275,0.024147006,0.08233577,-0.07784398,0.073914744,0.017115084,0.014407374,-0.045276344,-0.05537993,0.030457325,-0.04308825,-0.08044412,-0.032713685,0.034814753,-0.019084895,0.026530193,0.060880408,0.050487276,-0.0043265643,-0.012569147,0.06650092,-0.0157098,0.070751704,0.008844671,-0.07084939,-0.07760387,0.054434635,-0.066280335,-0.028290581,0.04305158,0.10158769,0.025327945,0.024121363,0.1316209,0.018474171,-0.042921495,-0.07809918,0.0068568536,0.06830387,-0.0021166662,0.06397786,0.03837014,0.016408551,-0.00516764,0.010513981,-0.020298634,-0.013262169,0.044220712,0.010659797,-0.003198256,0.025027527,0.0013077843,0.014362367,-0.009423319,0.014437079,-0.05504339,-0.03581302,-0.06686169,-0.09697003,-0.002001209,-0.08982614,-0.04671962,0.044309605,-0.0052265464,-0.042443905,-0.0010341739,0.029491419,-0.060202837,0.004993692,-0.023865102,-4.9693412e-08,0.100355916,-0.06592781,0.0482885,-0.04784471,0.014429615,-0.023787232,0.0065524303,0.02409621,0.009398875,0.01609918,-0.012872749,-0.10740903,0.04057508,-0.055954587,0.0662151,0.08431936,0.0014021639,-0.006245105,0.010455633,-0.078748934,-0.039216764,-0.063294046,0.017598303,0.03454992,-0.014478798,-0.026770478,0.05858086,0.13888732,0.010761804,-0.056157272,0.043658745,-0.0014535789,0.06597709,-0.014654692,-0.08557582,0.016830422,-0.034121618,-0.054629948,-0.03391119,0.03520289,0.005518722,-0.011081346,0.06197377,-0.039959703,-0.068081826,-0.023969796,0.080711484,-0.019117767,-0.0035483085,0.005302832,-0.018915018,-0.0032308763,-0.006466514,0.011472531,-0.027886912,-0.050283566,0.027978059,-0.023707254,-0.007994545,-0.04443031,0.025564013,0.05891671,0.0057649324,-0.054978464 +3.1.1.121,"The enzyme has been detected in fungal species that belong to the Ascomycota and Basidiomycota phyla, and has been characterized from the fungus Aspergillus fumigatus.",384,0.99999994,-0.022181714,-0.020048404,-0.18014394,0.036427192,0.045027614,0.016853776,-0.08350787,0.018738046,-0.0027433224,-0.05846134,0.11051749,-0.07766328,-0.045340054,0.08158074,-0.13460977,0.02855926,0.035211086,0.017842764,-0.014302191,-0.055467147,0.104326226,0.049903687,0.04028945,0.054418165,0.010290817,-0.073563375,-0.016833177,-0.018229593,-0.09282797,-0.08765296,-0.106421,0.018090568,0.103449166,-0.01908879,0.08444228,0.04165775,-0.06435906,-0.029596942,0.1108671,-0.016579853,-0.027592756,-0.053850338,-0.002606344,-0.055149417,-0.08448743,-0.015040627,-0.01865365,0.03901563,0.138303,0.0196732,-0.043031123,0.014356612,-0.0016428415,0.004035959,-0.030442145,0.032343566,0.025277004,-0.068422854,-0.0592135,0.07520365,-0.007954328,0.03058774,-0.033671144,0.0014593314,-0.04942153,0.014640562,0.021318318,-0.07590729,0.007842746,-0.05836931,-0.0092670545,-0.09075038,0.0012303245,0.023648322,0.08508159,0.059715703,-0.023467317,0.015480654,0.023340702,-0.01188909,0.0628984,0.028342847,0.011509664,0.0022256426,0.03953173,-0.021953529,0.017205797,0.049449913,0.020678505,0.009130543,0.059739836,0.028492983,-0.03822454,-0.023767587,-0.030578377,0.041478842,0.0751172,0.081813276,0.049738247,-0.047479764,-0.005196378,-0.0751554,0.03157914,-0.056813348,0.013707476,-0.030442847,-0.0024925708,0.011898964,0.13244337,-0.04295097,0.012851366,-0.030212432,0.027037922,-0.07871447,0.025564572,0.021864386,0.05111263,0.026447363,-0.053377084,0.013402938,0.06749412,0.0068224985,0.028973974,0.00030779862,0.061822683,0.04525964,-0.09485129,1.5721767e-33,0.051987763,0.07637757,-0.0071914205,-0.020640811,-0.007479924,-0.016415993,-0.011786129,0.01642808,-0.08123736,-0.061997257,-0.060745057,-0.011639057,-0.06536829,0.035793547,-0.025235906,-0.023043409,0.06460685,-0.07438463,0.02897722,0.021765366,0.04283846,0.055845488,-0.07576683,0.0035064055,0.015467595,-0.008996433,-0.008227621,0.024803514,0.013630306,-0.011884118,0.04048985,-0.06078845,-0.13141772,-0.03146843,0.074638635,-0.0059291786,-0.017183011,-0.026034793,-0.06729805,-0.040438034,-0.00525739,0.06927411,-0.00787672,-0.047911674,0.0019849704,-0.022326404,-0.06366113,0.058713384,0.08744662,0.07559483,0.025343023,0.029182993,0.10161871,0.041866653,0.01814485,0.03904735,0.010512305,0.012392302,0.014573185,0.081717275,0.017459199,0.022506753,-0.02371977,0.04383139,-0.024241135,-0.016074898,-0.07963881,0.020515952,0.014972078,0.015554158,-0.075435564,-0.0098802615,-0.08992672,0.030088313,-0.019784607,-0.08691416,-0.06382252,0.0047679,-0.034043014,-0.044319205,0.0041674674,-0.012776875,0.079065636,-0.009929782,-0.110369295,0.024734447,0.005138858,0.019698132,-0.02677465,-0.030211648,-0.03444618,-0.036364064,-0.03919319,0.07645634,0.09482743,-4.644139e-33,0.08941928,-0.081876986,0.075748205,-0.032157674,-0.08066688,0.0771377,0.020550746,0.044624835,-0.032155246,0.024651056,0.063824125,0.016476743,0.047361527,-0.011552788,0.014529097,0.085916646,0.004132106,0.07885848,0.05523058,0.038917907,-0.08109739,0.10731136,-0.011465398,-0.0399854,0.045955688,-0.032855507,0.051908728,0.04232081,-0.05914691,0.0007467242,0.004003845,0.082132846,-0.012636561,-0.01832406,-0.046514984,-0.0012761373,0.0049458747,-0.05519942,0.026945198,0.052319653,-0.010066445,0.036967285,-7.5459764e-05,0.03896334,0.042635754,0.039758254,-0.020091843,0.0733506,0.014111908,-0.04576354,-0.0014760034,0.013904568,0.0233471,-0.04754758,-0.009618681,-0.01462292,-0.0010741656,-0.012595256,-0.01735619,-0.026089104,-0.02796189,-0.030255577,-0.014470245,0.02954956,0.019767039,0.05271156,-0.061620887,-0.046102006,0.05667398,-0.035723813,0.014164683,0.019529326,-0.06776916,0.059889045,-0.045849387,-0.021409286,-0.041795194,0.0493839,-0.016645372,0.06503593,0.03192764,-0.06216648,0.07909353,-0.04797483,-0.044901684,-0.10970561,0.092472926,0.005695637,-0.09869736,0.03855726,-0.00538306,-0.030942606,-0.062435888,-0.008234569,0.08701919,-3.061631e-08,0.07313068,0.008478135,0.05584348,-0.15153058,-0.014278624,-0.0013820449,0.04360212,-0.0456795,0.01138974,-0.029077576,-0.06815106,0.039615497,-0.049693868,0.06305243,0.038469985,0.0062130583,-0.043140832,0.033206474,0.017020201,0.097296834,-0.011716227,-0.049554337,-0.09103539,0.048784867,-0.039625898,-0.02274347,0.047788434,0.015210526,0.009427732,0.027814092,-0.03771308,0.011847186,0.014158232,-0.10580288,-0.05478289,-0.0046819802,-0.053982735,-0.07901743,-0.009126596,0.051380403,0.054001175,-0.097424865,-0.04408235,-0.03445811,-0.04645403,-0.04536494,0.04052193,0.011205493,0.0020590734,0.008564622,0.03872747,-0.038653236,-0.008058798,-0.032603115,-0.04407436,-0.03595004,0.06379317,-0.034539998,-0.041795388,-0.05718411,-0.0053101303,-0.006383588,0.14603241,-0.030039623 +3.4.11.27,"The enzyme from the archaeon Pyrococcus horikoshii OT3 is thermostable. In that enzyme Cys100 is the nucleophile responsible for the proteolytic activity, while Tyr120 regulates the catalytic conformation of Cys100 through a hydrogen bond, thereby affecting enzyme activity. The activity with L-Arginine is 90-300 times higher than with other N-terminal amino acids. The enzyme shows low endopeptidase activity.",384,1.0,-0.07736491,-0.031446736,-0.14378099,-0.09547603,0.08085419,0.019415073,-0.029996864,0.08682716,-0.011739298,0.029376166,0.0358421,-0.014858272,-0.042363383,0.0977576,-0.03587378,-0.0061271186,-0.07151717,-0.04283235,0.042462945,-0.086939275,0.056373138,0.055930905,0.018633243,0.013944968,0.006452644,-0.06520381,0.016684048,0.015319976,-0.060017228,0.026185561,-0.033363804,-0.046513394,0.027808681,-0.11019302,0.07053191,0.07625758,-0.10303229,-0.05627143,-0.004270528,-0.010772201,0.070558034,-0.010429516,-0.010803615,-0.025578938,-0.00037572088,0.08147591,0.076517455,-0.007749506,0.0037076955,-0.014598219,0.027815461,-0.021274077,-0.0075402874,-0.034845617,-0.05660404,0.081791416,-0.075742275,-0.03723731,-0.031686295,-0.04756107,0.03525905,0.027494224,-0.02486362,-0.0142248655,0.057559773,-0.03420556,0.045495763,-0.042557202,-0.017525034,-0.007289668,-0.03396512,-0.03981611,-0.06538471,0.011110959,-0.0043572984,0.045436535,0.0007380044,-0.06808591,-0.0055775517,-0.042172823,0.049501203,-0.083331965,0.0075306315,0.0830128,-0.011600955,-0.0050819623,0.049389422,0.010049757,0.021254262,0.042423718,0.038748696,-0.030637829,-0.027826415,-0.03289665,-0.052459832,-0.008113405,-0.0029286633,0.037420735,-0.007004417,-0.031775195,-0.01984576,0.018937718,0.0104204025,-0.11917094,-0.019794561,0.048462417,0.06587405,0.03176992,0.061799474,0.035228178,0.012681666,-0.029973047,0.07792333,-0.012414365,0.0009904345,0.018902525,0.009346715,-0.019206591,-0.04272275,0.059309617,0.005178124,-0.01172518,0.07617399,0.06660151,-0.030765064,0.057816193,-0.07549565,4.942211e-33,0.03885405,0.003214122,-0.0016903912,-0.0020949699,0.09031361,-0.0029623376,-0.054271962,-0.015554677,-0.029914297,-0.046190184,-0.08020529,-0.036350086,0.05825325,0.019083535,-0.073254585,-0.01782501,-0.0033416576,0.047199592,-0.018275123,0.014543756,0.010534719,0.04687198,0.011021112,-0.014956676,0.050140135,0.091189876,0.011261861,0.007083009,-0.027652878,-0.0013226104,0.047977254,-0.1256327,-0.11899471,0.028738895,0.076519236,-0.023099981,0.045901142,-0.060082898,0.008852893,-0.06075479,-0.021194426,0.028463915,0.031361576,0.0054359967,0.064414844,-0.0567637,-0.013925166,0.14925972,-0.035634596,0.030049343,0.06381651,-0.059808247,-0.0015777935,-0.011442078,-0.0018187141,-0.014268075,-0.00594495,0.035471376,0.040324595,0.03185668,0.027890412,0.067272015,-0.069082715,-0.011954715,0.027229825,0.04217862,-0.016549928,-0.07749648,-0.025935927,0.08766989,-0.046315245,0.0016290927,0.050341696,0.08872197,-0.0059003136,0.053206928,-0.030550376,-0.021331903,-0.011389666,-0.02468972,-0.020232739,0.037976243,0.045365978,0.054897703,-0.06347864,-0.047239307,-0.008562749,-0.022184588,-0.0058512017,0.12296128,0.07448911,-0.07542458,-0.020866843,0.11498152,-0.088561065,-3.8472953e-33,0.04319536,-0.07413202,0.0029588041,-0.08600662,-0.08812855,0.076628715,0.054609038,-0.01965007,0.04609853,-0.059626114,0.12313882,-0.035382003,0.01393721,-0.049495816,0.030178713,-0.061115332,0.012432438,0.12991445,0.0019286294,-0.009140618,-0.0070964103,0.07306571,-0.034419563,-0.013839318,-0.0035371135,0.01653992,-0.014866307,0.10771967,-0.043962434,0.049873568,-0.031530373,-0.025149578,-0.024207681,-0.0558644,-0.021079987,0.077525266,0.0022671367,-0.05618595,0.052295465,-0.008903385,0.07060061,0.034601327,-0.024148608,-0.0023776721,0.010040421,0.033511616,-0.063637584,-0.023075284,0.0280219,0.017148973,0.0775935,-0.073250085,0.058287375,0.018292135,0.04183174,0.0115236435,-0.00817863,-0.026120951,-0.045381732,-0.009518946,0.026359098,-0.052122336,0.064638,0.123311274,0.018515045,0.082153805,-0.049148455,0.05314625,0.031755418,0.008358975,0.070324555,0.010094166,0.03222254,0.014092043,-0.038393173,-0.0043301997,-0.067829214,-0.05192386,0.0858078,-0.117930636,-0.07583352,0.0149171185,-0.030183353,-0.053866316,0.0010117572,-0.06648255,0.024878185,0.09648962,0.038264878,0.0024898504,0.031363994,-0.041784618,-0.0045846906,0.07595382,0.06347211,-3.910303e-08,0.04659245,-0.006332628,0.06644796,-0.024249254,-0.08382706,0.036717758,0.043987438,-0.023524715,0.035909332,-0.03463697,0.09147983,0.066956855,-0.014117895,-0.038552027,0.055059258,0.027580874,-0.016131463,0.05151736,-0.051908992,-0.084488615,-0.028966362,0.042145215,-0.088768445,-0.059041783,0.033755805,-0.044996202,0.028706636,0.09363478,-0.0061230003,-0.09287433,-0.016180454,-0.008171232,-0.06830702,-0.029843453,-0.046026904,0.07308229,-0.03190261,0.036789555,-0.022136766,-0.005607207,-0.029630248,-0.02700597,-0.11329288,0.002143303,-0.022018401,-0.005780207,0.023624387,-0.042350117,-0.05451108,-0.023215719,0.07591198,0.035258394,0.04955722,-0.03086774,-0.15478212,-0.015985519,0.0048848996,-0.034555368,-0.07527167,-0.022007136,0.02826599,0.02708236,0.11805783,-0.027992936 +3.5.1.138,"The enzyme, characterized from the bacterium Enterococcus faecalis, is a member of the Ser-Ser-Lys triad amidohydrolase family. cf. EC 2.3.1.313, NAD-dependent lipoamidase.",384,0.99999994,-0.039093997,-0.10916266,-0.10897031,-0.025185393,0.028165905,0.013897157,-0.101377375,0.034267772,0.04110244,-0.03674462,0.020367922,-0.07028358,-0.042643964,0.069570564,-0.031123245,-0.05934479,-0.0856194,-0.08044948,0.0550089,0.0103416,0.09249122,0.101330034,0.05507838,-0.020481803,-0.016434636,-0.023819191,0.06314583,-0.032954235,-0.0465819,-0.05433892,-0.06512809,-0.025764592,0.06873442,-0.050003603,0.06560697,0.01603153,0.036771793,0.019315615,0.094093084,-0.0011526975,-0.0006065591,-0.031072015,0.009858376,-0.015505702,-0.027535193,-0.052836232,0.0057865675,0.026567418,0.0883438,0.009028951,-0.0422681,-0.06810007,-0.035728667,0.052698366,0.03392999,-0.03392551,-0.019590402,-0.061212815,-0.042210642,-0.052431624,0.027018901,0.032427885,0.036666468,-0.013863565,0.010891715,-0.0530388,0.07978395,-0.08301912,-0.0018858806,-0.05024748,-0.13198647,-0.085685655,-0.002570561,0.081350744,-0.02202062,0.07772515,-0.05475097,-0.015749734,0.04600633,-0.004221823,0.04688439,0.027711077,-0.064817876,0.13029303,0.013353837,-0.03429576,0.04336182,0.009302543,0.07474809,-0.06178814,-0.009696072,-0.12026994,-0.02727637,-0.03152855,-0.07597511,-0.042105876,0.008024348,-0.031672403,0.011337027,0.0023419762,-0.014801504,0.033783704,0.0256426,-0.0904183,-0.04812253,0.018175734,-0.003816249,0.057844475,0.025871811,-0.03342956,-0.031737268,-0.0045684925,-0.0021061492,-0.0035819437,-0.030916197,0.009826809,0.034837257,-0.055390123,-0.06871793,-0.01816808,0.0034076497,0.017066611,0.0788887,0.059965264,0.0036091413,0.035520762,-0.13917165,-2.5808487e-33,0.03174682,0.02700179,0.042325843,-0.06956412,0.013842672,-0.057916336,-0.081045315,0.014653051,-0.033925828,-0.023933234,-0.05982816,-0.086787656,0.054726608,0.024905372,0.011943495,0.022157969,0.0037868235,-0.003656772,-0.0043868963,0.010165414,-0.029592006,0.12262358,0.02186466,0.0034699966,0.07242144,0.0132372985,-0.03078447,0.023706423,0.08145789,0.020276455,0.051889148,-0.112841524,-0.07515114,-0.03000871,0.06375493,0.0052246954,0.031174943,-0.05816348,-0.0005897832,-0.035520412,-0.025181076,0.032748807,0.04369572,-0.036916453,-0.043963768,-0.088106155,-0.05717637,0.06449774,0.040488154,0.027933657,0.009544365,-0.060214877,0.06495318,-0.04707258,-0.06259975,-0.020751221,0.0075286278,0.033872996,0.01152305,0.06304307,0.008495941,-0.009955972,-0.02635456,0.047789678,-0.06120385,-0.0055287355,-0.07681877,0.021649484,0.077143654,0.119034715,-0.059962217,0.026785886,0.010064617,0.028252352,0.042387072,-0.063606784,-0.038782798,0.0058099083,0.050099812,0.00072197133,-0.027149014,-0.018899065,-0.010854654,0.020420192,-0.070675395,0.022031028,-0.025939383,0.038897377,-0.0701871,0.05565104,0.007555452,-0.02090373,-0.00063743815,0.05127694,0.019516086,-1.191165e-33,0.075042166,-0.046396058,0.058707193,-0.16113326,-0.004615875,0.063415915,0.05263765,0.052568015,0.010517598,-0.014562829,0.041510314,0.052476633,0.07893995,-0.037792105,0.030174049,0.02897738,-0.012814872,-0.012268821,0.009166395,-0.046488278,0.0039616227,0.021823527,0.057862397,-0.040967744,0.03763253,0.027208451,-0.028456228,0.1631133,-0.099795416,0.055224672,-0.015714783,0.011965645,-0.031465985,-0.07962134,-0.044723146,0.030364564,-0.010502451,-0.062390335,-0.020409714,-0.04790094,0.01683622,0.056126956,0.017258875,0.06721738,0.0068159862,0.041676063,-0.025377667,0.02066352,0.046010777,-0.05150932,-0.012790522,0.035986137,0.06617762,0.02886929,0.008218384,0.08976801,-0.029558513,0.03397032,-0.035911262,0.018324135,-0.05065423,-0.04991885,-0.0072496273,0.043919813,0.07666575,-0.046705108,-0.072459385,-0.022689102,0.06668485,-0.056727532,0.080744736,0.035449322,0.0022043006,0.03611951,-0.004476972,-0.084612064,-0.08090855,-0.030348627,0.01649047,-0.010396924,0.020099422,-0.050686326,0.012031776,-0.023738448,-0.011818207,-0.035081673,0.036572736,0.081635885,-0.015380077,0.033979017,-0.0013172232,0.005001431,-0.09833466,0.03175209,0.044682477,-3.4362852e-08,0.054430995,-0.07898311,0.04149577,-0.037578534,-0.006360322,0.049923245,-0.016037967,0.007321595,0.027579227,0.016040847,0.05550659,0.109727755,-0.02893462,0.013003739,-0.009974617,-0.011504749,-0.08161196,0.076608725,-0.03899768,-0.011808518,-0.024437346,-0.028519843,-0.077165954,0.035372276,0.025690982,-0.00574706,0.004893914,0.016976023,-0.073083036,-0.0029324878,-0.005516142,0.015691772,-0.03328066,-0.029234942,-0.07765687,0.01695954,-0.04508094,-0.005839321,0.009690539,0.10587121,0.08751684,-0.0027583695,-0.09727215,0.005209583,0.041071367,0.0664318,0.013024983,0.07185793,-0.021819726,-0.027823282,0.014434323,0.019607432,-0.007053416,-0.010678208,-0.0919306,-0.0076683415,-0.049870715,-0.052515447,-0.00075542723,-0.025184643,0.05779778,0.039298065,0.23214297,-0.0043235887 +4.1.2.64,"The enzyme, characterized from the bacteria Veillonella ratti and Campylobacter jejuni, participates in an L-fucose degradation pathway. It also has significant activity with 2-dehydro-3-deoxy-D-pentonate (cf. EC 4.1.2.28, 2-dehydro-3-deoxy-D-pentonate aldolase).",384,1.0,-0.03631064,-0.015759757,-0.050038375,-0.021662692,0.031823985,-0.009859599,-0.030482536,-0.010152553,0.06970304,0.024636526,0.028152375,-0.04247987,-0.053658865,0.112161405,-0.026971353,0.031321816,-0.09213431,0.027965361,-0.025469448,-0.026221616,0.055071507,0.045933224,-0.008550929,-0.029055176,0.031771805,-0.07554599,0.05840499,0.0021489358,-0.07992063,-0.060869846,-0.00032429537,-0.030291643,0.05520546,-0.10342536,0.10204906,0.035530396,-0.068582274,-0.05566292,0.13015129,0.066236876,-0.02200637,-0.003897512,0.021597384,-0.055914484,-0.0383545,-0.03763393,-0.0068507222,0.047443733,0.064018235,-0.034339964,-0.041604232,-0.029234441,-0.017794847,0.04360796,0.01895858,-0.023741543,-0.019859537,-0.0036437989,-0.1073992,0.07323244,0.030984806,0.09124623,-0.04074453,0.0073464923,-0.012627479,-0.041651495,0.035162464,-0.06406198,0.019666974,-0.039949585,-0.029320186,-0.078714915,-0.011372461,-0.050982364,0.050252963,0.030705694,-0.05147587,-0.023019973,-0.018635785,-0.0013170989,0.058896143,0.016804323,0.06568143,0.06081437,0.012865653,-0.08148782,-0.019751737,0.0008405515,0.051152527,0.04969111,-0.0077293115,-0.007947747,-0.12069796,-0.00050408434,-0.016688187,-0.03610042,0.068225525,0.086874,-0.016830008,0.016881697,-0.07798687,0.032388147,-0.028995546,-0.07572017,-0.010972326,0.025259728,0.09576734,0.101332985,0.051916506,-0.062005114,0.00020726366,0.03780285,0.07133452,-0.016277194,-0.04313912,0.083938874,0.0677374,-0.04886258,0.012098667,0.049369417,0.03833268,-0.0598075,0.072844505,0.056560323,-0.027755652,0.059549518,-0.0582019,3.3040765e-34,0.061889853,0.007594031,-0.005216491,0.049802423,0.04286984,-0.05879666,-0.067783475,-0.07961107,-0.09115915,-0.05296122,-0.08870552,-0.0557247,0.010253939,0.07193318,-0.0076955273,0.0022887369,-0.032392792,0.008826561,0.06277463,-0.020001436,0.057150606,0.0022793123,-0.025666833,-0.03445437,0.07735303,0.049584698,0.02534779,0.0774708,-0.04821338,0.013525638,0.012482877,-0.078202225,-0.1095179,-0.06307107,0.05467029,0.012023964,-0.063249804,-0.039661232,-0.022917183,-0.0076348837,0.018384444,0.044404477,-0.02464679,-0.02688361,0.014239809,-0.05159706,-0.012467485,0.11185304,0.0738412,0.08303767,0.08593474,-0.022539472,0.04207325,-0.011531192,-0.069480576,-0.04213445,0.053418715,-0.014155526,0.038617685,0.057103075,0.027345821,0.06994295,-0.08723837,0.017875219,0.04030142,-0.0028699709,-0.055535078,-0.054639436,0.06255131,0.03309197,-0.12502235,-0.05753446,0.072664365,-0.046378236,0.029293029,-0.06470599,-0.030383635,0.016481135,0.03153124,-0.035448287,0.045219213,-0.049981106,-0.009959319,-0.01982026,-0.08930161,-0.0053937924,-0.014668396,-0.0056518363,0.011593528,0.026238918,0.030738045,0.024264455,-0.04593664,0.03126857,0.060888514,-1.38951055e-33,-0.0063685165,-0.0588135,0.049165986,-0.055816345,-0.10208028,0.03147231,-0.023365982,0.007967329,0.036545165,-0.03545811,0.042712435,0.024352347,0.049637638,-0.036106348,0.0008455414,0.030406537,-0.0025559047,-0.011985979,-0.057513546,-0.05828808,0.005297852,0.09239269,-0.015040423,-0.08572992,0.031537257,-0.018482637,0.01591215,0.082928404,0.04268316,0.026870577,0.03475433,0.05167142,0.013913138,-0.011960661,0.0064843516,0.027314136,-0.05440541,-0.042277656,0.0094735995,-0.01512745,0.028359154,0.005132941,0.040938582,0.051381197,0.05304838,0.052563056,-0.05374824,-0.035293363,0.0010508795,0.012701496,0.031525142,-0.030778054,-0.05361942,-0.024323648,0.02297244,0.050897762,-0.005443369,-0.03641489,-0.03257205,-0.04399254,-0.018441498,-0.006640021,0.07496647,0.028619958,0.05636389,-2.3434512e-05,-0.022217399,0.086399235,0.07331128,0.03336798,0.12071701,0.04328306,0.00080812204,0.043946438,-0.057367116,0.011154663,-0.122061595,0.04287663,-0.009595703,0.044417173,0.016135292,-0.058325794,-0.02462675,-0.053652514,0.012191222,-0.057940673,-0.0031234252,0.13789442,-0.02276776,0.016102325,0.028035078,-0.060887624,-0.0776918,0.027581804,0.021522842,-4.0895912e-08,-0.004572052,-0.059981514,-0.042057343,0.035022374,-0.034608852,-0.013727001,0.08477014,0.03610195,0.055724073,0.0130199855,0.031746555,0.11502222,-0.015922146,-0.01797109,0.004129534,0.06587348,-0.045148354,0.015937023,-0.015809566,0.045629784,-0.05599447,0.0024098668,-0.06793929,-0.003833941,-0.012698621,-0.07541122,-0.028110204,0.13389926,-0.021085124,-0.03338212,0.029616635,0.031753406,0.0048011737,-0.016046312,-0.12460455,-0.0028063878,-0.08853558,-0.014672726,-0.056982927,0.10326636,0.054123472,-0.03550032,-0.04743085,-0.0035722475,-0.017926287,0.03183379,-0.0038703938,0.04672724,-0.075881384,-0.053778656,0.05767011,0.0006878462,-0.031811897,0.06432187,-0.11150999,0.04628262,-0.028721303,0.045351606,0.032505065,-0.09425223,-0.022016076,0.009943594,0.16246395,-0.058677357 +4.1.99.28,"Requires Mg2+. This enzyme, isolated from the bacterium Microbacterium 5-2b, participates in a carminate degradation pathway. Following the activity of EC 1.1.3.50, C-glycoside oxidase, it cleaves the C---C bond in 3'-dehydrocarminate. The sugar moiety is released lacking a hydroxyl at position 1, and containing a double bond between C-1 and C-2. The enzyme shows weak activity with other 3'-dehydro-C-glucosides.",384,1.0,-0.05919307,-0.051192854,-0.056086056,0.0467248,0.060651958,-0.033397567,-0.033599727,0.024056772,0.003180089,0.00018809293,0.026377756,-0.0145287,-0.017419312,0.0058452203,-0.017140998,0.006678199,-0.0140694305,0.00085105683,-0.03764646,0.0010463124,0.104074076,0.0048195566,-0.029073257,-0.02111099,0.003311696,0.025604866,0.057028163,-0.04609822,-0.042344145,-0.06217591,0.01670257,-0.042871386,0.10029783,-0.0321282,0.06081846,0.076512165,-0.03333409,-0.09089051,0.06711856,-0.046661183,-0.002881539,0.04788665,0.04168301,-0.017168894,-0.00338386,-0.0882192,0.011125356,0.024961345,0.029380286,0.009686243,-0.0073261578,-0.061796337,-0.048493937,0.0020767634,0.01919575,-0.018473525,-0.09596832,0.022398556,-0.009545922,0.009560527,0.039527837,0.030202169,0.032685004,0.021660969,-0.060836434,-0.076346934,0.07251832,-0.12643765,-0.003016827,0.025975687,-0.1047679,-0.13045308,-0.009293887,-0.0064295433,-0.007779471,0.029387964,-0.0104076015,-0.08467172,0.03990365,-0.021643633,-0.021733478,-0.05754291,0.088516526,0.049388617,-0.0037813408,-0.056306485,0.09257022,-0.00960483,0.0409727,0.052004214,0.02245974,0.024201794,0.026752472,0.009994858,-0.056919616,0.0058880392,0.009092899,0.013799299,-0.021189144,-0.0046859263,-0.054125305,0.14004508,0.021233013,-0.019476686,-0.051377896,0.040458504,-0.030293135,0.10072819,0.079776965,0.006796908,0.039888714,0.01321746,-0.029138135,-0.03480525,-0.025225414,0.057712097,0.029770412,-0.046666306,-0.054682113,-0.021417191,0.053076863,-0.06381671,0.008731555,-0.025290528,-0.07529292,0.064525045,-0.025986366,1.2219465e-33,0.005137946,-0.02043015,0.035620064,-0.01877343,0.019519191,0.011725373,-0.08668774,0.033945244,0.013804978,0.011521734,-0.08804863,-0.05667315,0.026852435,0.03937938,-0.030218266,0.02131244,-0.008772769,-0.02173165,0.08038263,0.06575803,0.0019332345,0.028394299,0.02212944,-0.054338828,0.074250534,0.09355283,0.06331199,0.014031812,0.10465258,0.0025574486,0.04438867,-0.11008004,-0.08715689,-0.02007567,0.072154835,0.0135638695,-0.046378918,0.03749462,0.027836222,0.061549675,-0.02383371,-0.0025156792,-0.015382815,-0.068898395,0.05988041,-0.01914323,0.0053625223,0.09748174,0.021097744,0.072678655,0.052987505,-0.062448177,0.014498775,0.069252245,-0.04191311,0.05675023,-0.02511918,0.054875452,0.022983057,0.012669188,0.028234249,0.07695089,0.02238784,0.00210307,0.02308101,0.0552923,-0.12680013,0.011099293,-0.005060093,0.05099496,-0.061616648,0.009039905,0.06887323,0.028105414,0.0011204459,-0.011641713,-0.03740964,0.04327368,0.08010054,0.0075179925,-0.042939898,-0.036388397,0.052491136,-0.012532269,-0.034467176,0.050359264,-0.09868121,-0.027977314,-0.008165228,0.062650174,0.026133426,-0.030487534,-0.015634434,0.03226774,-0.05285691,-3.3501887e-33,0.082408115,-0.093645826,0.039462566,-0.0715398,-0.029457705,0.020174818,-0.044378135,-0.057803392,-0.021498345,-0.00030989404,0.07037406,0.09052036,0.016094228,-0.06999448,0.03728827,-0.033445816,-0.013397348,0.088730834,-0.098255925,-0.0034427268,0.06502209,0.056777675,-0.024493368,-0.038822226,0.042436216,0.035666935,0.013206994,0.054245956,0.09795394,0.045555398,0.016855866,0.05541802,0.010256043,-0.09258018,-0.022888707,0.04284045,-0.075296596,-0.04729451,0.04192879,0.029783713,-0.011263227,0.062141113,0.020682551,0.059573207,0.09460676,0.062283207,-0.06590094,0.046609618,0.0012308735,-0.04059173,-0.012252628,-0.050903436,-0.055397127,-0.020341143,0.035069067,0.050639324,0.020346995,0.022478523,-0.014744798,0.01124848,-0.054232698,-0.02137869,0.09510895,-0.0061648358,0.019855825,0.047614537,0.005308548,0.09026929,0.0382152,0.009452732,0.07126784,-0.0080019,-0.046730105,-0.017309498,-0.009647213,0.048062332,-0.068719774,0.004931784,0.048699446,-0.031055197,0.034444973,0.002223873,-0.012288384,-0.06522268,0.008044649,-0.11736094,-0.03149247,0.086052135,0.0326347,0.037533693,-0.09503728,-0.027702585,-0.066629454,-0.003600961,0.0072167446,-4.6753033e-08,-0.0066242763,-0.04575087,0.05800911,-0.05870567,0.05048173,0.06997839,-0.048837706,-0.027141854,0.075077444,-0.047113135,0.015218461,0.046832345,-0.042411435,-0.015857505,-0.053885043,0.014040848,-0.0747659,-0.024758158,-0.014470338,0.037519887,-0.14289291,-0.08156222,-0.12155321,0.054372486,0.037785295,-0.14664961,0.0120711,0.06091258,-0.09187911,-0.008505204,0.008126539,0.086404964,0.023054205,0.022744326,-0.08760593,-0.06741453,-0.046190545,0.0241297,-0.059935164,0.016986938,-0.02485983,-0.03424505,-0.045061003,-0.013386959,-0.009488013,0.016502447,-0.009502481,0.02567251,-0.13729829,0.003029427,-0.006372575,-0.038100027,-0.10765196,-0.000107912914,-0.07351765,0.004037777,-0.011839018,-0.0327476,-0.057249114,-0.06163795,-0.031606816,-0.029009167,0.12443711,-0.0010798967 +4.2.99.25,"The enzyme, found in bacteria and archaea, is involved in the degradation of polysaccharides such as alginate and pectin. The enzyme catalyses a pyranose ring-opening reaction followed by enol-keto tautomerization.",384,1.0,-0.0064258766,-0.03540991,-0.049350813,-0.026988877,0.020377075,0.014072996,-0.025114086,-0.033900514,0.058736343,0.059065733,-0.030928198,0.025052441,-0.08651423,0.019907417,-0.076666445,0.10164137,-0.09015671,0.0082282005,0.024687784,-0.034627542,0.09982666,-0.00069242064,-0.022099046,0.02698737,-0.01435232,0.009778032,0.040187463,-0.0045219385,-0.068421215,-0.08735105,-0.03411057,0.025026845,0.038187113,-0.046239253,0.016959753,0.14717047,-0.045037176,-0.021906074,0.055447128,-0.0883952,0.0561866,-0.026599396,0.00361374,-0.020823933,-0.03454284,-0.005342877,0.0104814395,0.037679378,0.03967995,-0.05049234,-0.01630036,-0.060764093,-0.03542589,-0.010705456,0.107431345,0.038214542,-0.021170126,-0.044748984,-0.018703245,-0.0067561152,0.061400324,0.006887896,-0.03673585,0.04397794,-0.03246657,-0.0593223,0.08395486,-0.03377078,-0.04368729,0.025718007,-0.07330377,-0.04921881,-0.11909556,0.023886364,0.05816965,0.04588837,-0.025496019,-0.10813302,-0.055624068,0.020170597,0.062519915,0.02160386,0.016279502,0.0349622,0.0146168955,-0.025526438,0.064013526,-0.02781043,0.05733683,-0.03984145,0.05642052,-0.015093257,-0.02181705,-0.028486244,-0.011782617,0.008573803,0.020247305,-0.014510279,0.04413346,-0.0049166614,-0.064941205,0.00019132956,0.02728763,-0.1330841,-0.04578577,0.087303676,0.016331462,0.10260492,0.076637685,0.03096062,-0.0707852,-0.007825924,0.02818584,0.034872144,-0.054292448,0.04928061,0.07784681,-0.062646344,-0.066158615,0.016899044,-0.033771727,-0.030500783,0.026249202,0.07614016,-0.07966387,0.0119099235,-0.10065344,1.6052712e-33,0.013552336,-0.06421842,0.04656065,-0.0517781,0.07900184,-0.03902174,-0.030901173,-0.033430092,0.008089625,-0.07175481,-0.07242151,-0.104190744,0.055054553,0.036129467,0.00967726,0.030995432,0.0025748427,0.019749783,0.023592737,0.043116603,-0.027876591,0.055597305,-0.048573468,-0.0083022425,0.01889873,0.0933508,0.04691927,0.0075581027,0.017507663,-0.03791648,0.043653477,-0.02342551,-0.1348689,0.014280765,0.09221864,0.044972483,-0.01967048,0.0042017023,-0.01599309,0.039065048,-0.0026172611,0.004481707,0.013508253,0.0027254082,-0.0062750545,-0.053022694,-0.019593276,0.1126912,0.023135606,0.0677743,0.06115386,-0.008275942,-0.005536364,0.030169785,-0.06441608,0.06289577,-0.013185834,-0.056162786,0.0028014057,-0.0015410035,0.0110616945,-0.012175693,-0.00902997,-0.015503247,-0.0069294246,0.02107002,-0.056259256,-0.02785752,-0.0068469304,0.0435739,-0.1086893,0.018759653,-0.018837715,0.009684085,0.005941027,-0.015745662,-0.10363077,-0.033654213,0.042839907,0.006113774,0.019310461,-0.053309083,0.025447115,0.0012490095,-0.066193156,-0.017300235,-0.037733983,-0.010004671,0.04083305,0.059097677,0.0024140307,-0.029353684,-0.07678949,0.07668717,0.01840537,-3.8423968e-33,0.106069684,-0.102371514,0.08942438,-0.024477545,-0.0419641,0.024113236,-0.028355107,-0.0018857106,0.0008473349,-0.05574276,0.027487356,-0.0030127782,0.050714124,-0.039367035,0.049592093,-0.00083066255,0.010272556,0.046591446,-0.041873906,-0.014893023,0.0028202254,0.08074523,-0.030774416,-0.036663402,0.013613125,-0.00016797424,-0.0029436052,0.043507025,0.04831324,0.045698058,-0.03896643,-0.03609101,-0.036920816,-0.011347177,-0.040272113,0.06835308,-0.039424945,-0.021570643,0.05175431,-0.010731701,0.072348215,0.09483371,0.006114697,0.006257016,0.049349442,0.08422343,-0.06527148,0.058379903,-0.007099506,-0.07540523,0.05797689,0.043641865,0.04711737,0.0007276365,0.06407664,0.076662034,0.015398552,-0.0072694398,0.010860445,-0.030171553,-0.07433238,-0.04852168,0.07941885,-0.0049650567,0.022537405,0.037216198,-0.04304877,0.037638895,-0.015602744,-0.026746932,0.10530447,0.020375963,-0.062543474,0.09177378,-0.03336828,-0.020256398,-0.11369234,-0.054354254,-0.023215743,0.0062285424,0.033052817,-0.008370321,-0.0016519278,-0.092796825,-0.00670171,-0.083895735,0.079148374,0.06156404,-0.048970018,0.01625184,-0.03155303,-0.045311313,-0.06455797,0.07245699,0.061649576,-3.311719e-08,0.009108918,-0.031168735,-0.012685779,-0.035668693,-0.011345048,0.0051687397,0.07027422,0.09618668,0.06440461,-0.07319825,-0.030345293,0.10438722,-0.027263412,0.056547094,0.014531732,0.06572548,-0.02444804,-0.034915984,-0.02836787,-0.036694482,-0.10142843,-0.0063694865,-0.11565028,0.057106737,-0.010216507,-0.025246758,0.042580206,0.10896372,-0.06557445,-0.028404767,-0.0024359005,0.053448927,0.013032566,-0.019009115,-0.047336202,0.05445139,-0.044683583,-0.046369888,0.04174462,0.012619821,-0.0062159933,-0.023373568,-0.036979567,-0.0573231,-0.00814589,0.038021237,0.0072098756,0.05699588,-0.08286016,0.044083413,0.1099799,0.01612191,-0.03600012,-0.07050601,-0.10816271,-0.005875694,0.046091408,-0.04533611,0.0048280014,-0.047067348,-0.004599808,-0.03727009,0.2142473,-0.03206804 +4.3.1.33,"A pyridoxal 5'-phosphate enzyme. This bacterial enzyme, characterized from the marine bacterium Vibrio splendidus, expands the substrate scope of a widespread pathway for the degradation of 2-aminoethylphosphonate. The enzyme is highly specific and does not act on the S enantiomer of 1-hydroxy-2-aminoethylphosphonate or other structurally related compounds.",384,1.0,-0.051050864,-0.060466282,-0.017936204,-0.11631621,0.020231728,0.045676496,-0.055927172,0.06824742,-0.0036107288,0.05611273,-0.009467631,-0.046792958,-0.03436481,0.067357615,-0.044227194,0.026950173,-0.03628829,-0.033902284,0.028854262,0.004666905,0.08891784,0.074613094,-0.037583735,0.0019642601,0.035158355,0.096990965,0.022370223,0.06830931,-0.036624763,0.0017012196,-0.027683778,0.037912216,0.030294048,-0.10766595,0.08698178,0.10521755,-0.09805965,-0.032983556,0.061004173,-0.008098488,0.021091944,-0.011746606,-0.03970503,-0.0049893367,-0.07987198,-0.014887454,0.04158829,0.0537999,0.054053985,-0.056345634,-0.074398905,-0.094059855,-0.020066235,-0.034415822,-0.025790723,0.036288813,-0.0012241128,-0.058951166,-0.056616522,-0.033771742,0.06238119,0.019058501,0.02916247,0.051948007,0.034173332,0.016634954,0.06998601,-0.053506598,-0.040080085,0.016529782,-0.0787125,-0.054066304,0.050485045,0.037414595,-0.040119186,0.029535709,-0.005840473,-0.06264932,0.042080536,-0.056643654,-0.009007247,-0.044376742,0.004734906,0.013145489,0.032724436,-0.0036471249,0.051171433,-0.047280163,0.073361196,-0.013300928,0.0017198854,-0.012949209,0.042608604,-0.11505702,-0.028688211,0.052629568,-0.094312884,-0.0050594425,0.033652775,0.00045590903,-0.008332481,0.011963498,-0.012055504,-0.11683884,-0.02856034,0.018806793,-0.016432052,0.069167666,0.028701462,-0.038012244,-0.11887726,0.049490333,0.028059859,0.022944212,0.0071375794,0.076866336,0.05544733,0.022965362,-0.091579676,0.060048785,0.062395625,-0.100294955,0.02960128,0.02506311,-0.07470288,0.04008982,-0.049724218,2.038827e-33,0.046321567,0.006260438,0.056777716,-0.044361815,0.038768582,0.008419302,-0.049061447,0.011625724,-0.10435497,-0.036868926,-0.046156485,-0.043579493,0.049664725,0.044124078,0.020003667,-0.0063025258,-0.037086226,0.106903724,0.034050357,-0.012630705,0.08126212,0.069802925,0.0017114662,0.038734857,-0.016741466,0.053804006,0.028160306,-0.010862329,0.0027544447,-0.013280268,0.02154779,-0.060557973,-0.1143876,-0.032101914,0.08274864,-0.086386554,-0.06692841,-0.021801615,-0.0021317236,0.0023217087,0.014691077,0.032518663,-0.03574535,0.03176216,0.032126594,-0.06669302,-0.06728627,0.09361047,0.026188932,0.00476007,0.053669833,-0.021584168,0.032562926,-0.029910997,-0.05080587,0.0013571288,0.07794057,0.013128573,0.0036070663,-0.029921347,0.030876981,0.04792847,-0.0065298826,-0.026689135,0.035523925,-0.03471521,0.028466191,-0.07180214,0.031773597,0.05939863,-0.02316493,0.04403553,0.014278598,0.05737496,-0.008840049,-0.08810114,-0.007326171,-0.052205473,0.019972961,-0.00064240105,-0.045679893,-0.029591069,0.025377704,-0.046278432,-0.023194285,-0.07979189,-0.017037822,-0.073871225,-0.007782045,0.041238196,0.03546646,-0.08563342,-0.05984982,0.0073701013,-0.02988757,-3.1997606e-33,0.043096412,-0.033090375,0.061731417,-0.018820388,-0.0738442,0.06380366,0.062044907,0.07070017,0.0027827153,-0.018046604,0.06547889,0.025395028,0.09184697,-0.0425387,0.018133743,0.03212893,0.060600773,0.024449015,0.015662696,-0.05976067,0.05464912,0.02645725,0.06606285,0.029202506,0.042688996,0.036033306,-0.024620544,0.061599873,-0.06982903,0.07328175,0.0068669766,0.04119617,-0.029869618,-0.053738534,-0.051717006,0.06883142,-0.034437925,-0.016570373,0.026640229,0.009168945,0.02266529,0.084149756,0.09064623,0.008446031,-0.06960933,0.005210453,-0.047489792,0.016887406,-0.03363922,-0.0860135,0.025742142,0.012909031,-0.00085126027,0.0016859978,0.032338575,0.0031515493,-0.05705015,-0.031685703,-0.05669951,-0.00021764064,0.002110542,-0.056008875,0.022582581,0.045319267,0.043959353,0.074687555,0.06425173,0.033087377,0.010515129,-0.052458636,0.09095499,0.02172185,0.012247304,0.08964977,-0.020701824,-0.0015165132,-0.057361733,-0.02735272,-0.019356834,-0.028770637,0.046180252,-0.008090046,-0.054998323,-0.11100437,-0.011707551,-0.13959858,0.0853604,0.096235484,0.042159908,0.006001099,-0.015367639,-0.009424773,-0.0641078,0.015410665,0.124180965,-3.7311835e-08,0.06355226,-0.048856206,0.07143006,-0.033107866,0.027575515,-0.046255343,0.023911797,0.013787166,0.12568627,-0.06484297,0.03172575,-0.0057904613,0.01439538,0.017332537,0.0765556,0.021653185,-0.029542603,0.07526801,-0.049955115,-0.05028852,-0.037504867,0.00079216214,-0.08461742,-0.03250459,0.05424372,0.002666246,-0.005700151,-0.016240308,-0.018392473,-0.03355824,0.018270178,0.020295803,-0.037423167,-0.02416966,-0.09446644,0.064243086,-0.11142839,-0.011631116,-0.06549807,0.056509264,-0.024362035,0.008668873,-0.08027326,0.022501662,0.021534888,0.042793747,-0.011262845,0.048016295,-0.03843234,-0.045777958,0.05179379,0.005851747,-0.020184204,-0.07534046,-0.16047461,0.046475437,0.036128417,-0.0017242358,-0.06519726,-0.08007404,-0.015972376,-0.026865609,0.14983495,-0.021013917 +5.1.1.25,"The enzyme, present in bacteria and archaea, participates in a pathway for the degradation of D-glutamate.",384,1.0,-0.07246391,-0.032117747,0.002377553,-0.025007704,0.018369278,-0.014351932,-0.033009253,0.030133419,0.045208678,0.032554477,-0.028530454,-0.009669267,-0.015060588,0.05598714,-0.016367072,-0.00024464875,-0.07916734,0.0064239134,-0.05410134,-0.014492024,0.08285614,0.1342134,-0.05970019,-0.06368985,0.048078537,0.056596298,0.108172946,-0.059614886,0.00044396476,-0.037641987,0.0005225636,-0.043936472,0.09684562,0.0103186155,0.0363919,0.07969967,-0.036936283,-0.044860158,0.074667916,-0.08725132,0.02910448,0.10040968,0.03238831,-0.05237293,-0.031230338,0.035655472,0.026986085,-0.027819404,-0.0019182832,-0.03529048,0.039933357,-0.047360327,-0.023012517,0.038419668,0.06971758,0.06818817,-0.0028721117,-0.05351682,-0.04662559,0.010913168,0.061041184,0.04504203,0.02657067,0.009319569,0.037376937,-0.06766209,0.09542719,-0.009610806,0.039626468,-0.07425362,-0.08257107,-0.06347906,0.0035908632,-0.023925044,-0.02073855,-0.01890301,0.035787538,-0.07962146,0.03734238,-0.096779145,0.10539716,0.016250446,0.071476534,0.032426395,0.022841362,-0.0133540295,0.01700703,-0.025259951,0.0659293,0.022114754,0.014680154,-0.04543329,-0.02271545,-0.06494001,-0.08415595,-0.007700182,0.009009266,0.007025305,-0.0027881064,-0.0074490733,-0.018520776,0.08313296,-0.0129359495,-0.08336742,-0.06427339,-0.0061255926,0.0051329187,0.11037443,0.015991196,-0.0013220831,0.04957154,0.018085822,0.039687414,0.07678095,-0.058660377,0.0122491475,0.072306834,-0.020931311,-0.13176043,0.04570563,-0.048618723,-0.04894278,0.049256038,0.020519808,-0.07813187,0.023126638,-0.06103213,-3.72467e-33,0.030931003,-0.08201601,-0.0472333,-0.05950971,0.059712686,-0.057894398,-0.052318472,-0.017351123,0.04084561,-0.045560278,-0.07044613,-0.10018242,-7.6072305e-05,-0.0016142395,-0.0010907102,0.063924335,-0.04254471,-0.0009842343,0.02833087,-0.029255256,0.024831302,0.046100184,-0.02725848,-0.022144238,0.037520584,0.052063648,0.044283934,0.06539447,0.025356006,-0.01378488,-0.04139168,-0.11512124,-0.13363507,0.014100767,0.08666351,0.041899506,-0.036267947,-5.7853307e-05,-0.0052160206,0.029501554,-0.022913098,-0.002916384,-0.07011885,-0.016175278,0.03194949,-0.02915447,-0.00024191146,0.11278021,-0.019985793,0.08777099,0.031039689,-0.10031581,0.050270963,-0.021521036,-0.088830344,0.025843376,-0.0046063378,-0.061090786,0.082359046,0.024254333,0.011483757,0.035830215,-0.0788709,0.06898691,0.06392232,0.016873332,-0.02187648,-0.062226158,0.00708679,0.05585993,-0.04325469,-0.058705855,0.03801261,0.0030744912,-0.061126713,-0.06751837,-0.060468372,-0.00055959576,0.04740442,-0.013532315,-0.035459463,-0.04157905,-0.017394228,-0.0054196715,-0.010547838,0.0243906,0.003158552,-0.079247445,-0.028314693,-0.009684421,0.02622753,-0.025046706,-0.06126353,0.040899817,0.024684109,4.0502595e-34,0.06003826,-0.044106312,0.015636796,-0.02938066,-0.04785527,0.056482,-0.018251067,0.008988783,-0.010168785,-0.06382968,-0.022166597,0.05650465,-0.010137531,-0.0023604042,0.022437308,-0.02940676,-0.0111134155,0.018152045,-0.03386408,-0.0017695123,0.078973815,0.06930274,-2.3515597e-05,-0.005671325,0.03543475,-0.019909132,0.0073240497,0.06055225,0.016644625,0.053902764,0.044312615,0.04254146,-0.031470757,-0.038088765,-0.04966346,0.038848665,0.01664358,-0.01107328,-0.037249744,-0.014157936,0.032340806,0.10620545,0.054637223,0.042179145,0.013333371,0.07015412,-0.045841,0.03252331,0.004611566,-0.060351375,0.06208315,-0.032497946,0.037749,-0.04011125,-0.010350009,0.04637381,0.058963876,0.012431553,-0.04638479,0.01758624,-0.07474026,-0.121748224,0.048837412,0.029459398,0.023578616,0.0101150265,0.07848523,0.09695154,0.009866426,-0.04697363,0.07870723,0.0052793347,0.0166672,0.031492297,-0.09757742,-0.048309732,-0.06966295,0.005174389,0.10278836,-0.03389375,0.010750648,0.012365372,-0.03153708,-0.05779377,-0.02713307,-0.14913653,-0.0036734059,0.13986163,0.023341263,0.036324143,-0.06694853,-0.05817729,-0.050522808,-0.00557654,0.0324632,-2.3944414e-08,0.003144142,-0.026961394,0.011283748,-0.015174788,0.048590638,0.047359195,-0.01496869,0.066931166,0.109045625,-0.039779443,0.023671657,0.07438909,-0.096445136,0.024213554,-0.03249115,0.090779714,-0.06669043,0.0019779117,-0.05183273,0.008978022,-0.052792065,-0.055511672,-0.07724585,0.032731425,0.06382738,-0.055071812,0.030475752,0.09709601,-0.051506776,-0.018545048,-0.025901156,0.060790382,0.027756423,-0.049843885,-0.07604101,-0.027234038,0.03424692,-0.052135583,-0.008965832,0.051458336,-0.013199715,0.06290745,-0.050291933,-0.006773575,-0.019065835,0.03845252,-0.0052069053,0.043067988,-0.06598048,-0.0072437366,0.05443339,-0.041153036,-0.008928855,-0.031731304,-0.15613237,-0.014624764,-0.004475032,-0.04920586,-0.04653872,-0.024024168,0.07321295,0.043070544,0.11919407,-0.0128259575 +7.5.2.14,"Unlike heteropolymeric O antigens, which are polymerized in the periplasm by EC 2.4.99.27, O-antigen polymerase Wzy, homopolymeric O antigens are polymerized inside the cytoplasm by a progressive transfer of sugar monomers to a growing chain attached to a polyprenyl diphosphate membrane anchor. When the chain reaches its full length it is transported across the cytoplasmic membrane by this ABC-type transporter, which consists of an ATP-binding subunit (Wzt) and an integral membrane protein (Wzm). Wzm proteins are poorly conserved in their primary sequence. Once in the periplasm, the O antigen is ligated to the lipid A-core complex by EC 2.4.99.26, O-antigen ligase.",384,1.0,-0.08464967,0.009318508,-0.011634398,6.430425e-05,-0.022412559,-0.012549044,0.069453344,0.07717335,0.06952931,-0.029204307,0.051921763,0.08959849,-0.07066408,0.07045279,-0.017920757,0.053594258,-0.06140285,0.051104683,-0.027363101,-0.055077966,0.100209005,-0.05241861,0.015064413,-0.06835855,-0.09161666,0.010737371,-0.029697824,0.08074448,0.056658715,-0.07835133,-0.088972785,-0.063989185,-0.03382905,-0.0019971754,0.013188853,-0.00031342683,0.018832888,-0.124527946,-0.063344404,-0.0020341629,0.16624476,0.01906808,-0.028236488,0.033442803,-0.037528127,-0.009253262,0.040883347,0.033805273,-0.06965144,0.021825278,-0.05168062,-0.13851063,-0.01526038,0.02169077,-0.052785225,0.035196744,-0.052590664,0.00321645,0.043775044,-0.053492863,-0.064175166,0.018248599,0.024109894,0.046954107,0.05046966,-0.042492323,0.06802994,-0.02470335,-0.04766164,6.7116984e-05,-0.0544403,-0.012696921,-0.029976608,0.030931752,0.022921808,0.031481225,-0.0031748407,-0.021211222,0.032006636,0.012157194,0.05734412,-0.008715009,-0.026093798,0.06984845,0.010836082,0.016864052,-0.026635952,0.0293691,-0.03447737,-0.004768196,-0.029271163,-0.046448063,-0.024832666,0.01571526,-0.071116105,0.0029341134,0.06055045,0.017792003,0.054069705,0.017767811,0.023685416,-0.015996128,0.09716767,-0.020997575,0.011815038,0.003948229,-0.029772243,0.046644587,-0.0520904,0.04480435,-0.033008892,-0.019644476,0.07816983,0.009857689,-0.04904894,0.0148126595,-0.030468654,0.036863822,0.041606896,0.009968046,-0.07462947,-0.05805122,0.018092,0.0601404,0.041406717,0.07332202,-0.075338125,2.350842e-33,0.0001783458,-0.040554155,0.026809577,0.034676697,-0.08079661,0.0049086744,0.01836319,-0.009091856,-0.034927566,-0.022305094,-0.057975437,-0.07375789,0.03717838,0.04846822,-0.0097828945,-0.07182712,-0.027576488,0.056082904,-0.0035162987,0.07087327,0.04327374,0.07066023,-0.0043098624,-0.040639192,0.08903982,0.013678277,-0.08693407,-0.085409924,0.07258402,-0.010112213,0.045098502,-0.08061708,-0.06934815,0.023197114,0.10785344,0.03637182,-0.0009646678,-0.052598294,0.036355373,-0.095705286,-0.065959476,-0.08950893,-0.026493208,0.036065158,0.06571354,-0.046003506,-0.055346638,-0.0017541449,-0.010676578,-0.024085741,0.05830384,-0.027692271,-0.017586349,-0.018146627,-0.10093253,-0.016041407,-0.05107468,0.03220398,0.013342254,0.03375833,-0.004378751,0.105624445,-0.06480208,-0.01984725,0.06408304,0.033749897,-0.114081375,-0.027538305,-0.0007799115,0.069167696,0.074384786,-0.106741,0.023843452,0.061196584,0.05529735,0.015449092,-0.0030679465,0.029410373,0.023234338,0.04238479,0.053011343,-0.018668048,0.023597572,-0.07303595,-0.06650711,-0.054277822,0.053393066,-0.04339671,0.029469082,0.06726176,0.101698175,-0.012475404,-0.035210963,0.01687426,-0.0028863773,-4.2149613e-33,0.030138573,-0.052401043,0.11927354,-0.039697543,-0.07446404,0.007848886,-0.0089945495,0.032030992,0.0001583515,-0.033929925,0.06553362,0.031666927,0.021033464,-0.032175623,-0.012239232,-0.022533402,-0.107981384,0.096138805,-0.010298958,0.037850995,-0.07469118,0.03627664,0.05530712,0.1088616,-0.018439677,0.0022901027,0.07682859,0.036172736,-0.009193276,0.045315646,-0.016405541,-0.009571035,-0.06536296,-0.0079701515,-0.051530205,-0.010654076,-0.041689236,0.02957416,0.035854526,0.009953107,-0.038748544,-0.07370901,0.046429608,-0.023609659,0.051349733,0.13649179,-0.040431555,0.045646537,-0.03498365,0.013306093,-0.0206959,0.0557777,-0.010275822,0.022815939,0.005940314,0.056240954,0.05041604,-0.053298924,0.0050523877,-0.05679677,-0.020225504,-0.04981705,0.04223745,0.04361844,0.048197642,0.019284867,0.055650186,-0.054580368,-0.038763568,-0.036168896,-0.01344231,0.08877513,-0.03238213,-0.04309504,0.07042988,0.03329026,-0.03682946,0.0117820185,-0.02092171,-0.05255407,-0.06585451,0.0049189986,0.015704263,-0.0062268646,0.09174055,-0.052826177,0.06049279,0.019361626,-0.02725626,0.023915663,0.01578255,-0.045662124,-0.038249932,0.012911886,0.055032637,-4.6496925e-08,0.0075602783,-0.058298763,0.010292742,-0.088759765,-0.044970177,0.012439865,-0.028423082,-0.032988515,0.081885874,0.093801424,0.039153367,0.089468636,-0.044315916,-0.02322765,0.02839891,0.026941832,-0.042574536,-0.0137220025,0.01041213,-0.055601757,-0.06428267,-0.031062653,-0.03667046,0.12996055,0.0377842,0.0016917672,0.05722136,0.035763916,-0.0062772385,-0.04328346,0.014444171,0.036579423,-0.020253448,-0.004090344,-0.019138845,0.0114123365,0.07685124,-0.021824317,-0.044563074,0.001905127,0.05283855,-0.018784393,0.0020804058,-0.033993077,0.03226618,0.022893546,-0.0035134135,0.011375614,-0.07294024,0.031371012,0.05348818,-0.039290186,-0.052261204,-0.060776085,-0.12184905,-0.09540537,-0.025539702,-0.049567144,-0.0036821708,0.03316825,-0.010627054,-0.015614175,0.21159747,-0.04671304 +1.3.1.126,"The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 2.1.1.391, demethylgadusol O-methyltransferase.",384,1.0,-0.052842736,0.030593703,-0.019329205,-0.005786102,0.059293136,0.013292463,-0.005794698,0.04548029,0.04684014,0.0024346763,0.07216682,-0.06373776,-0.03755151,0.027359214,0.014598571,0.072271444,-0.09833875,-0.023445537,0.007535275,-0.08751266,0.059093256,0.032208726,-0.0128560765,-0.038173426,0.0044174083,0.016002838,0.044023868,-0.1050164,0.033518832,-0.06730085,0.053408448,-0.067521326,0.03548288,-0.06522238,0.045549225,0.06402791,-0.008930544,-0.08939526,0.009317908,0.066535175,0.044028975,-0.045147803,-0.055535708,-0.08018217,-0.055826455,-0.0019599397,0.037035957,-0.018627504,-0.03965395,-0.03213739,-0.03599642,-0.034313004,-0.03906555,-0.005583312,0.011401172,0.064031176,-0.118303016,-0.057739258,-0.021557158,-0.0065688747,0.055355847,-0.021357957,-0.00039356537,0.023900824,-0.0095067015,-1.5139393e-05,0.11147071,-0.058077574,-0.033766538,-0.040989216,-0.103953995,-0.04491437,0.0249082,0.03068624,-0.009839479,0.035981413,0.046911456,-0.010891564,0.079661146,-0.017192483,-0.010811234,-0.07687326,-0.024629992,0.04948254,0.05808829,0.027202595,0.07721956,0.046100825,0.023169352,0.015472171,-0.0030209695,-0.06638633,0.0012049531,-0.06874578,-0.005851253,0.033795957,-0.019379463,0.025431087,0.029357674,-0.03308507,-0.021662915,0.027168287,-0.013987594,-0.049352203,-0.05549698,-0.021590482,0.00039590625,0.09926648,0.05350648,0.004405368,-0.038563333,0.012148788,0.050765414,0.062085696,-0.06497614,0.085291155,0.037199207,-0.066462435,-0.059555165,0.012832383,0.09741655,-0.041059494,0.043481417,0.0542563,-0.029255046,-0.0011841104,-0.05117014,1.0820298e-33,0.0402308,0.042812742,-0.041045025,-0.064399324,0.044709243,0.05227567,-0.07146422,0.035639495,-0.087585784,-0.03522958,-0.08661694,0.0018886179,0.038344625,0.12542836,0.023900371,0.042190358,-0.006944608,0.008353514,0.04569623,-0.042557888,0.011577118,0.04298036,-0.01400682,0.011799654,-0.03480813,0.035225872,-0.054443557,-0.049388427,-0.04355516,-0.0006007046,0.07730628,-0.16760229,-0.04554766,0.097945884,0.09455465,0.03340427,0.020470731,-0.0661363,-0.020067403,0.083290234,-0.023206007,-0.0022197308,0.06913942,-0.009884226,-0.0054720794,-0.042137533,-0.01234676,0.04654104,0.048996408,0.036546864,0.031017743,-0.0016369083,0.036515508,-0.063548245,-0.030251952,0.04979298,-0.0548154,-0.012339354,-0.044986248,-0.007827537,-0.07292665,0.04558462,0.005883288,-0.007475331,-0.008142537,-0.04215367,-0.05966804,-0.03732288,-0.016917992,0.039803445,-0.029976236,0.023900954,0.0453551,-0.02374103,0.03291729,0.00492805,-0.034055892,0.00044630194,-0.008082192,0.06179549,-0.0054134517,0.027571315,0.036359385,-0.09591317,-0.055591233,0.0065110903,0.00326099,0.007954889,0.014872945,0.060633034,0.023929011,-0.06504324,-0.029017465,-0.020001763,0.044183414,-1.7437013e-33,0.036137223,-0.08568042,0.037565045,-0.119878665,-0.004029451,0.02344021,0.12730525,0.025183383,-0.010321602,-0.041336764,0.046304815,0.07278703,0.069568075,-0.02570433,0.033598475,-0.01887829,0.04183672,0.056207202,0.044270743,-0.064020544,-0.023389725,0.09591484,0.050802935,0.012199071,0.07357506,0.047526553,0.048453644,0.0055540577,0.039124765,0.013427632,-0.12439293,0.026113413,-0.0024624267,2.3934168e-05,0.061693367,0.06843966,0.019378636,0.030207781,-0.04338509,-0.03039978,-0.015025521,0.0075491904,-0.02359139,0.0048798416,0.021047859,0.14771,-0.028517846,0.02424944,-0.032112166,-0.038542993,0.013126055,0.04846725,0.010425486,0.021426912,0.077941306,0.01209684,-0.03202301,-0.022480752,0.0066427574,-0.0033281017,0.0068400665,-0.055551358,0.0743066,-0.034131266,0.026732989,0.071669444,-0.056287963,0.047140393,-0.027170476,-0.0705831,0.09177485,-0.022133768,-0.025530817,0.023956023,-0.029826034,-0.017100368,-0.10819538,-0.08868165,0.0035494964,-0.02162349,0.007249081,0.012943246,-0.0489843,-0.04881899,-0.05145055,-0.09970776,-0.003732171,0.108833544,0.03243322,-0.058468793,-0.10738016,0.013170816,-0.0981179,0.09448659,0.07591595,-3.560915e-08,-0.036463737,-0.07493124,0.037957266,-0.03806795,0.038419843,0.048322205,-0.0043346887,-0.011907598,0.03762472,-0.050438963,-0.045032788,0.08305145,0.026024103,0.00975217,0.029193433,0.013470272,-0.024663867,0.0044942317,0.004429745,-0.039560698,-0.032291666,-0.0052278475,-0.04739533,0.05411839,-0.013211983,-0.01986477,0.05988664,0.058941644,0.034365755,-0.040183716,0.007815351,0.027412215,0.047806036,0.016998455,-0.06694478,-0.017239464,-0.044752337,-0.021270731,-0.02414657,0.017445303,0.036846623,-0.022735983,0.008522092,0.009830928,-0.005533199,0.03122005,0.053304024,-0.02196392,-0.008788842,-0.0024099033,-0.0034010448,-0.108097516,-0.010715268,-0.04224745,-0.08509272,-0.123451926,0.04479162,-0.13986708,-0.0043811705,-0.0032734233,0.026791163,0.06322932,0.2432101,-0.036499176 +1.8.1.22,"Contains siroheme. The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. The system comprises the DsrAB reductase and the DsrL protein, which form a tight complex. The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. In sulfite reducers the DsrL component transfers two electrons from NADH to the DsrAB component, which then reduces the sulfur in sulfite to an S(II) intermediate that forms (together with two cysteine residues of DsrC) a trisulfide. In sulfur oxidizers the enzyme catalyses the opposite reaction [1].",384,1.0,-0.09692788,-0.018604947,-0.09923037,-0.022093687,0.0038118833,0.008337496,-0.03942485,0.09055111,0.039014913,-0.029948648,-0.053048283,0.027573358,-0.078758724,0.006650984,-0.033988006,0.04727778,-0.017004425,0.06725079,-0.023377169,-0.081718855,0.07880976,-0.016968604,-0.05490804,-0.008698838,0.03593704,0.0731934,0.02245213,0.018414002,-0.059246365,-0.07069022,0.02235482,-0.07849625,0.03990417,-0.019568225,0.013891448,0.0846623,0.010615255,0.003099539,-0.010906165,-0.06101968,0.006718315,0.07317634,-0.014489161,0.008057603,-0.026265642,-0.022562526,-0.06009196,0.05089805,-0.00722056,-0.08476445,-0.07177292,0.0056118425,-0.05478273,0.14552873,0.012538766,0.05685652,-0.011258952,-0.023092719,-0.02166347,-0.13067923,-0.038966484,-0.01737044,-0.009929865,-0.03609712,0.07553678,-0.012061336,0.028436087,-0.03349737,0.01953034,-0.020647023,-0.10455653,-0.02749275,-0.031367615,0.063073374,-0.041074473,0.026374292,-0.019014567,-0.020930808,0.118384264,-0.012962331,0.0650079,0.021466762,0.031263594,0.16438898,0.032225918,-0.0065732924,-0.029422397,-0.05273826,0.027993772,-0.033046603,0.00965018,-0.044336874,-0.010113982,-0.052550644,-0.08303971,-0.0017442147,0.009093487,0.089600846,-0.01589749,-0.01814249,0.012000794,0.022619285,-0.007948683,-0.09317665,-0.044141646,0.017943215,0.018291386,0.12200053,0.037557483,0.046948057,-0.011164657,0.055288132,0.01750397,0.03680967,-0.0406665,0.07097387,0.05738993,-0.0028053243,-0.07422195,-0.05270496,-0.0135665545,0.05520492,0.020712262,0.037690736,0.011918925,-0.030174052,-0.1528547,3.059679e-33,0.084123366,0.041929375,0.029837575,-0.030341689,-0.035199426,-0.05454918,-0.03146749,0.03845098,-0.0010848213,0.058214553,-0.08377304,-0.058729205,0.029849757,0.014529417,-0.036157478,-0.034929644,0.03224622,-0.008050526,0.050341703,-0.035742775,0.03295688,0.07763582,0.015502564,-0.010483972,0.07333798,0.019210776,0.020093394,0.017094802,-0.019816766,0.02604953,-0.029566053,-0.107153416,-0.052543283,0.071759865,0.09261978,-0.009994291,-0.057583388,-0.04455396,0.014194957,0.023129074,-0.041660514,0.012336086,-0.043022193,-0.05451536,0.041020658,-0.0717672,0.005945937,0.065004244,0.018280648,0.08256259,0.011158621,-0.0807651,0.088039815,0.023508044,-0.0028317298,-0.022536483,-0.029332075,-0.035813294,0.043593768,0.0813062,0.014601915,0.021373548,-0.07023426,-0.002475618,0.040378075,0.022059381,-0.051997643,-0.03932115,0.016666217,0.0886984,-0.08085003,0.015494117,0.04282615,0.026447669,0.029753355,-0.015551948,0.007911159,0.007600334,0.044037312,0.018378923,-0.03269252,-0.033127353,-0.014562129,0.01270879,-0.037303083,-0.057298284,0.028809965,-0.02073683,-0.07324919,-0.0013844485,-0.027500384,-0.10402351,-0.078896,0.045086302,0.0066589764,-3.9613833e-33,0.04050452,-0.0526604,0.039692592,-0.07180243,-0.043527912,0.057284456,0.01949015,-0.04051701,0.0890896,-0.028437203,0.041112162,-0.009391207,0.016102705,-0.020465758,0.009050911,0.029579997,-0.032149035,0.021103146,-0.043353237,-0.03668394,-0.016385354,0.17710757,0.027831228,0.015731853,0.032014452,-0.026558708,0.058352232,0.11309647,0.038527854,0.07211442,0.02724364,0.00037804156,-0.05988501,-0.07856181,-0.056225553,0.05700716,-0.056631245,0.038706314,0.007781464,0.021552302,0.03357338,-0.01905599,-0.019402124,0.08456932,0.044488054,0.011622799,-0.114919916,0.045801844,0.037815753,-0.05794611,0.06815752,-0.077446945,0.009278677,0.051700506,0.02447752,0.013277268,0.009608238,0.011031106,-0.07357337,-0.012331744,-0.036743373,-0.105187155,0.016093643,-0.011508935,0.010765509,0.03264064,0.008504362,-0.045824815,0.065459676,-0.01070509,0.03898109,0.012830025,-0.0066123386,0.024484057,0.018380065,-0.077870525,-0.09923441,0.033499427,0.031205667,0.030037805,-0.041532885,0.029467583,0.0062086144,-0.12427807,0.043189682,-0.021378139,-0.047578584,0.09741003,-0.027674133,0.028816579,-0.057052113,0.030337373,-0.020418443,0.09557625,0.007674209,-4.0229537e-08,0.05892009,0.03383315,0.07038678,0.031621557,-0.03081693,0.062154386,0.032727428,-0.008930089,-0.0060598403,0.04625466,0.023878563,0.12566505,0.0046520825,-0.048594892,0.041309483,-0.0005085617,-0.028013414,0.028601788,-0.03865728,-0.10003771,0.07833883,-0.062150024,-0.08343699,0.06174951,0.08599815,-0.07686952,0.06475948,-0.07094072,-0.028695978,0.0048265513,0.06716591,0.047399495,0.013750078,-0.04351105,-0.036536414,0.0066356896,-0.0022482544,-0.033602204,0.062274426,0.008728115,-0.018446662,0.025364166,-0.09839896,0.07070597,0.013235545,0.04961607,-0.0027048388,0.043227147,-0.06201354,0.054003194,0.037477072,-0.014583801,-0.040018734,-0.049994417,-0.104188345,0.032916076,0.030116046,-0.059090372,-0.022389948,-0.026151804,0.057985533,-0.030487923,0.069931045,-0.053262133 +1.8.5.10,"This enzyme complex is present in both sulfate-reducing bacteria and sulfur-oxidizing bacteria, and acts in opposite directions during the reductive and oxidative pathways, respectively. DsrM and DsrP contain b-type hemes, DsrJ contains c-type hemes, DsrO is a ferredoxin-like protein, and DsrK is the catalytic subunit that acts as a disulfide reductase on DsrC proteins that contain a trisulfide bridge [1,3,4]. The complex receives the electrons from the membrane quinone pool [2,3].",384,1.0,-0.1436102,-0.015014149,-0.101078704,-0.029973365,0.025400516,-0.055008035,-0.021417886,0.11857109,0.03222473,-0.0644316,-0.029179238,-0.010500314,-0.089373164,0.04436043,0.0043530343,0.045751188,-0.026504112,0.074277185,0.0026050182,-0.013707245,0.02071658,-0.016829034,-0.06662962,-0.006206594,0.0063471487,0.109510824,0.07238507,0.04897318,-0.056464184,-0.056917015,-0.011557193,-0.0386289,0.08143786,0.024004504,0.012812378,0.053042714,-0.0060488097,0.0046252296,0.039924607,-0.056280665,0.013700467,0.01674525,0.018742092,-0.020092241,0.012232927,0.002192929,-0.04005382,0.02547577,0.012806444,-0.025169048,-0.05735829,0.014024653,-0.0069102123,0.16060413,0.004420423,0.055145044,-0.017868398,0.008813743,-0.049435955,-0.04451353,-0.017680721,-0.039661124,0.00017802944,-0.04095277,0.03389127,-0.02614505,0.0018586925,0.007063403,0.03971208,-0.076236404,-0.055318184,0.0037055698,-0.021213777,0.017861623,-0.052386846,0.04398337,-0.00017680957,-0.013690281,0.119379774,-0.015960198,0.08194906,0.01871487,0.033313736,0.21409382,0.0067027737,0.03289509,-0.016207485,-0.053985626,-0.00027964823,0.018099943,-0.010679612,-0.008791888,-0.060295876,-0.07521401,-0.10644951,0.017510736,0.007876764,0.09791511,0.0063707083,0.0047231056,-0.022735514,0.043372292,-0.014976053,-0.07341465,-0.0589673,-0.028369365,0.030536288,0.10391631,0.072489955,-0.03230301,0.0024730705,0.047370624,0.051650275,0.021803398,-0.042291947,0.055385802,0.031741213,0.0134099955,-0.065683044,-0.042758267,-0.006747996,0.0074703647,0.005724127,-0.0026517978,0.029836096,-0.08003758,-0.08210631,1.6384195e-33,0.08587669,0.04550912,-0.015117435,-0.019859647,-0.04662186,-0.06006039,-0.060848247,0.03567935,-0.048234805,0.055035252,-0.1018554,-0.06104864,0.0134052895,-0.015435042,-0.031589996,-0.014441719,-0.0069900453,-0.02522625,0.03639141,-0.064924195,0.10023033,0.0777602,-0.01047129,-0.036760256,0.096739605,-0.0012831937,0.042673267,-0.00096115336,0.035292424,0.031524442,-0.005817379,-0.09013335,-0.030185997,0.07195572,0.06115403,0.010972685,-0.117879644,-0.020490455,-0.026269287,-0.011421912,-0.014128801,0.018157456,-0.03231588,-0.0097308345,0.065894455,-0.030754657,0.013076119,0.017334595,0.017005296,0.089622095,0.005056349,-0.05645217,0.06281922,0.015885277,-0.00521035,-0.061842605,-0.031368703,-0.017016396,0.025367804,0.08174026,0.022963362,0.059940416,-0.117327586,-0.020260815,0.033356845,0.038343817,-0.02095429,-0.029037202,0.025823861,0.09426936,-0.021920927,0.022942912,0.026148794,0.013136344,-0.010404629,-0.019094592,-0.011818707,0.026417285,0.1042692,-0.00036284752,-0.030410813,-0.049849167,0.024966555,0.016309228,-0.038531285,-0.0022476525,0.0053426134,-0.046055824,-0.06339021,-0.017826991,0.029265424,-0.12595396,-0.08469205,0.01459008,0.0052725086,-1.8083862e-33,0.034704816,-0.075678654,-0.0036112163,-0.06474312,-0.07320504,0.05543215,0.014622349,0.023439998,0.07043571,0.007993599,0.08355584,0.023385214,-0.0025789123,0.0016064243,0.044098098,0.021048287,-0.05319593,-0.01241879,-0.064850815,-0.017525375,0.00026548022,0.13290629,0.07501338,0.011281948,0.02716994,-0.007650035,0.08049375,0.113856964,0.054279733,0.079332106,0.014024054,0.011758839,-0.012801085,-0.04125157,-0.028761292,0.038711347,-0.050091747,0.022149153,0.0049311602,-0.03345454,0.0115556335,-0.07066234,0.009729447,0.06772566,0.027137052,0.060259644,-0.08159637,0.077726364,0.08226156,-0.039214738,0.013379182,-0.05462361,-0.04201208,0.0036346873,0.02879727,-0.007126436,-0.022616595,-0.0019407801,-0.14659514,0.0028617997,-0.025271552,-0.10448499,0.019386236,0.03347778,0.007997497,0.055135626,0.007994628,-0.0003417823,0.037419997,-0.01796922,0.04489203,0.02604461,0.007683488,-0.0051833084,0.022619935,-0.13706622,-0.077500165,0.085448466,0.047018487,0.031652503,-0.05763913,0.047963493,-0.017461859,-0.02644581,0.05238229,-0.031128235,-0.029362267,0.08159188,-0.04598771,0.024790453,-0.039711416,0.05220888,-0.011390227,0.07764829,0.0033878773,-3.4224833e-08,0.024722116,-0.015663924,0.06282451,0.020542458,-0.0032782832,0.048108082,0.0069547943,0.034711305,-0.033723693,0.067340896,0.007241944,0.1519509,-0.05689094,-0.112123474,0.030871075,-0.03500483,-0.029238164,-0.01964456,-0.028138619,-0.10431637,0.09165144,-0.080781475,-0.038614724,0.055303868,0.042609427,-0.04011675,0.01939878,-0.09196122,0.006678216,-0.038167257,0.051715985,0.05029719,0.00015959429,-0.0034131599,-0.023925269,-0.06306696,-0.027393123,-0.030685818,0.046850096,-0.01281725,0.035763673,0.023801265,-0.09650405,0.06318061,0.015181008,0.050073784,-0.0043443977,0.027986165,-0.034933668,-0.0075620417,0.034815174,-0.016648177,-0.018623091,0.014861386,-0.109284006,0.040924523,0.009376382,-0.052114014,-0.03441281,0.01579582,0.048797756,-0.036035344,0.0571403,-0.023492238 +2.1.1.391,"The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 1.3.1.126, 2-epi-5-epi-valiolone dehydrogenase.",384,1.0,-0.060135037,0.03491484,-0.02947545,-0.036009192,0.0710513,0.02102457,-0.011986326,0.017048296,0.008909049,0.01846826,0.059019282,-0.06946221,-0.03983517,0.016371606,0.0061630183,0.035376582,-0.08813661,-0.022967419,0.0014329273,-0.09530981,0.0532389,0.0071129785,-0.0142723005,-0.02238273,0.0043504173,0.022430407,0.050328925,-0.080356084,-0.015989097,-0.050368894,0.048570048,-0.09129995,0.04390496,-0.06351461,-0.0016629704,0.110125124,-0.030501511,-0.077793896,0.024488434,0.08979984,0.03408972,-0.053619243,-0.064020015,-0.07015835,-0.024798296,-0.024241341,-0.008788891,-0.0013358352,-0.022646688,-0.02572446,-0.033197515,-0.032926586,-0.023695504,-0.004319866,0.00016708214,0.06800838,-0.114017226,-0.047022317,-0.034643535,-0.008827383,0.06464574,-0.03807676,-0.0052205767,0.026684018,-0.0021314402,-0.0032157768,0.11363033,-0.078175254,-0.04314607,-0.059498735,-0.06016065,-0.02791108,0.009634949,0.033754237,-0.030791301,0.06017251,0.022134045,0.0039709546,0.053694244,-0.00654578,0.006715034,-0.052667014,-0.0019766854,0.056495946,0.07294686,0.03834958,0.083024144,0.038198873,0.026035195,0.043522824,0.0098760445,-0.06151913,-0.008933319,-0.04596857,-0.0017440636,0.049840678,-0.040419273,0.0046322434,0.0161633,-0.061649043,-0.03282187,0.01611763,-0.017250814,-0.037975386,-0.060652062,-0.007525161,-0.002316841,0.10036315,0.009735898,-0.0077356137,-0.043426435,-0.0010108163,0.052349906,0.05749854,-0.053113803,0.10145832,0.026944993,-0.08671114,-0.05311993,0.024943698,0.10428633,-0.010263607,0.039194148,0.06571598,-0.041654922,0.0036571836,-0.042482816,-1.8817727e-34,0.038341638,0.046327382,-0.05087559,-0.04469748,0.056093298,0.080023706,-0.08914607,0.04357303,-0.10635957,-0.04629008,-0.09142206,0.058438078,0.075417966,0.08592108,0.0445386,0.042379905,-0.0020031156,0.042916965,0.05728279,-0.05063441,0.0071539795,0.036172107,-0.025445392,0.00925077,-0.054099206,0.052249014,-0.061389115,-0.061017364,-0.035504587,0.0029261026,0.062866546,-0.15953253,-0.023702472,0.07513827,0.08467358,0.018004833,0.0164453,-0.055923123,-0.021936102,0.07762517,-0.017557133,0.0026762607,0.05999526,0.008990639,-0.02071334,-0.07814126,-0.011274295,0.0452555,0.046705894,0.035459302,0.043612823,0.007066753,0.044365365,-0.07131095,-0.056853496,0.081714205,-0.02589742,0.0037846311,-0.034643617,0.004198483,-0.058099043,0.087453835,0.017364828,-0.0022125992,0.0020471823,-0.038043514,-0.053820893,-0.06449544,-0.016876644,0.058635034,-0.04308495,0.015395274,0.04654912,-0.02390239,0.032247797,0.015163954,-0.036947224,-0.0011285003,-0.04998857,0.05076158,-0.020195175,0.023959322,0.020938743,-0.06299613,-0.035514116,0.01276069,0.0043322365,0.009123977,0.012937048,0.050656743,0.051267855,-0.057803042,-0.026906868,-0.028841734,0.06737834,-4.3046185e-34,0.07512388,-0.11009679,0.03204425,-0.10109677,-0.009526374,0.055643294,0.12190836,9.23935e-05,0.010218724,-0.011678571,0.046536062,0.04339419,0.04258534,-0.017940879,0.02005407,-0.0040135756,0.02641322,0.048628718,0.038818292,-0.08511804,-0.004290762,0.09268179,0.06946246,0.02083984,0.051534753,0.03384824,0.060299955,0.0027004124,0.018352315,0.012327564,-0.11104917,-0.005199239,-0.0010341366,0.013701421,0.06079295,0.088668466,0.022168111,0.01777703,0.0005486319,-0.021368595,-0.02013514,0.006517222,-0.010472928,-0.018098164,0.014963538,0.15127924,-0.01845155,0.034499098,-0.043996535,-0.041274786,0.020219995,0.040611096,-0.004179639,0.02053712,0.061414987,0.006154763,-0.032515068,-0.02737844,0.001458409,-0.0019131002,0.035280854,-0.040142253,0.07750835,-0.016965177,-0.00036594097,0.06928826,-0.052995306,0.04243013,-0.014059518,-0.069540985,0.09891109,-0.049790967,-7.140328e-07,0.06322352,-0.023040203,0.0037450446,-0.085700415,-0.07402748,0.027877588,-0.025267297,0.012666701,0.03788561,-0.06800608,-0.044438224,-0.054043695,-0.1125361,-0.009172794,0.11123469,0.037284747,-0.050378386,-0.084169485,0.012653554,-0.080939986,0.0718222,0.09962231,-3.570919e-08,-0.0057194596,-0.057675734,0.046651866,-0.038575258,0.03578474,0.018316403,0.029284952,-0.02563081,0.058865607,-0.07754188,-0.031344038,0.06400742,0.030119134,0.026857857,0.04469263,0.014500241,-0.008169356,0.0162215,0.0022542996,-0.017538691,-0.035500336,-0.012846096,-0.058392543,0.008810774,-0.011016221,-0.022608764,0.056607056,0.03172931,0.015696151,-0.016896775,0.0010918402,0.0025889901,0.03631744,0.0007885008,-0.07044783,0.008297423,-0.06684183,-0.0058347294,-0.057221707,0.005118331,0.012419915,-0.05639878,0.00807634,-0.010753418,-0.0099645285,0.038994472,0.056515615,-0.028459696,-0.010810919,-0.00071916165,-0.017563831,-0.102162756,0.014401464,-0.03244287,-0.105670296,-0.10121262,0.04331114,-0.17773846,-0.00498277,-0.027929978,0.02768857,0.076692276,0.22935942,-0.010664524 +2.3.3.22,"This family of enzymes participates in a process that introduces a methyl branch into nascent polyketide products. The process begins with EC 4.1.1.124, malonyl-[acp] decarboxylase, which converts the common extender unit malonyl-[acp] to acetyl-[acp]. The enzyme is a mutated form of a ketosynthase enzyme, in which a Cys residue in the active site is modified to a Ser residue, leaving the decarboxylase function intact, but nulifying the ability of the enzyme to form a carbon-carbon bond. Next, EC 2.3.3.22, 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase, utilizes the acetyl group to introduce the branch at the beta position of 3-oxoacyl intermediates attached to a polyketide synthase, forming a 3-hydroxy-3-carboxymethyl intermediate. This is followed by dehydration catalysed by EC 4.2.1.181, 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase (often referred to as an ECH1 domain), leaving a 3-carboxymethyl group and forming a double bond between the alpha and beta carbons. The process concludes with decarboxylation catalysed by EC 4.1.1.125, 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase (often referred to as an ECH2 domain), leaving a methyl branch at the beta carbon. The enzymes are usually encoded by a cluster of genes referred to as an ""HMGS cassette"", based on the similarity of the key enzyme to EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase. While the enzyme is similar to EC 2.3.3.10, it is specific for an [acyl-carrier protein] (acp)-bound donor and does not interact with a CoA substrate as donor.",384,1.0,-0.03920527,-0.027470605,-0.028627785,-0.019012328,0.06337326,0.014798754,-0.08492947,0.016096057,0.065225445,-0.056271214,0.029221326,-0.03783374,-0.08384552,-0.014638841,-0.045479584,0.050471734,-0.08916954,0.022297446,-0.023949318,-0.0061028404,0.065890536,-0.02076146,-0.034883264,-0.011418971,0.010489323,-0.011095016,0.053043857,-0.0594628,-0.041020416,-0.12211793,0.03527288,-0.014883648,0.004250204,0.006349461,0.059258137,0.10987663,-0.044002768,-0.059376985,0.03562137,0.009037902,0.074071325,-0.014471459,-0.010785542,-0.0009625154,0.001555865,-0.032771036,-0.10104782,-0.017401034,-0.014021093,-0.06181954,-0.00040227905,-0.011683567,-0.0060722213,0.035240855,-0.057351165,-0.0062943976,-0.05141007,0.02266927,-0.023971038,0.015426957,0.059508976,0.03703666,-0.0031120135,-0.04032504,0.0022608812,-0.019528568,0.061290797,-0.07119275,0.017477993,0.03560575,-0.13331503,-0.05912809,-0.034689117,0.038129054,0.040254004,-0.0073322887,-0.00247528,-0.03368475,0.07563911,0.010603264,-0.014433816,0.04079989,0.0619417,0.006978748,0.031495195,-0.00879104,0.02001721,0.009913665,-0.0068330886,0.049398094,-0.012512244,-0.05075881,-0.026455913,0.01856174,0.03131751,0.04218272,0.045910668,0.020631952,0.03277239,-0.0037290906,0.0014147261,0.08360556,-0.020552529,-0.15069765,-0.017728642,0.043888412,0.0016999774,0.060848635,0.06857037,0.024274345,-0.06953378,-0.017142318,-0.028202528,-0.034382433,-0.02534875,0.15678874,-0.031325657,-0.06501105,0.06616346,-0.026528493,0.06730714,-0.035664544,0.027458357,0.05415659,-0.02035535,0.03418927,-0.17307997,1.2787828e-33,0.019414041,0.029050801,0.03691077,-0.014210305,0.0133706,-0.03461659,-0.08762255,0.052123718,-0.09085645,-0.011221338,-0.06406871,-0.06542413,0.07375239,-0.014044614,-0.033679985,-0.09632226,-0.065621026,-0.0039871386,0.019741056,-0.03280212,-0.0232447,0.07085806,-0.070814565,0.071901895,-0.007605459,0.01400635,-0.010147713,0.0262667,0.042919725,0.009239714,-0.00480383,-0.0058504785,-0.06475805,0.04328582,0.0077339346,0.057709824,-0.004937431,-0.05387747,0.042129956,0.07513287,0.10842434,0.011890589,0.061389707,-0.08089018,0.024079632,-0.027485209,-0.06138205,0.054534543,0.034153346,0.030515622,0.03399658,0.024497041,0.025556237,0.012392221,-0.03983523,0.011721815,-0.12436275,-0.008674815,0.018139152,0.016975507,-0.016820785,0.00028441125,-0.03102894,0.01943851,-0.054184824,0.05845465,-0.043934617,-0.012532321,-0.0036996794,0.03340269,-0.075225145,0.019040737,0.082392775,0.043651775,0.046603605,-0.016574023,-0.070647314,0.034505446,0.04492699,0.04096281,-0.06834034,0.031841524,0.004334857,-0.040429253,-0.03389106,-0.053852115,-0.02313863,0.046848044,0.03110108,0.0641849,0.034797907,-0.071629025,0.034817453,0.08811088,-0.011535745,-3.1707256e-33,0.112932295,-0.10138224,0.0141667845,-0.071814284,-0.025901247,0.028358595,0.07655783,-0.07458951,0.007844475,-0.026284413,0.09166308,0.02392737,0.08339449,-0.018747559,0.030659882,0.026851803,-0.057176035,0.03694117,0.006751466,0.041083112,0.07539934,0.08027225,-0.011484566,0.077288866,0.044252224,0.014930714,-0.03768142,0.055715162,0.09817982,0.021426711,-0.041388612,-0.014125734,-0.009756567,0.0040709684,-0.061311103,0.036123835,-0.07499368,-0.0156040145,-0.01567264,0.043065626,-0.0074841273,-0.009419204,-0.045671128,0.058649607,0.10265818,0.10770498,-0.029764678,-0.0025559827,0.02479328,-0.0890008,-0.0021378582,0.028181948,0.009275655,0.050756924,-0.017231204,0.1295808,0.008836373,0.0074991537,0.0044556893,-0.0018925214,-0.04438439,-0.017156864,0.07358105,-0.06101827,0.036775045,0.015070403,-0.054983072,0.035722118,0.033508457,-0.027903017,0.028354837,0.03725642,-0.031444896,0.021268712,0.028385075,-0.0963424,-0.06104268,-0.051739,-0.06856363,-0.10883963,-0.05466531,0.011713593,0.0114337485,-0.044252727,-0.033152673,-0.05661744,0.056295566,0.10080575,-0.0458918,0.021371024,-0.05237584,0.026774712,-0.07811305,0.13148768,0.07474051,-4.981113e-08,0.0043672794,0.023466187,0.015458882,-0.05227752,0.02801486,0.06166408,0.004159366,0.04296049,-0.010236914,-0.09548676,-0.05405903,0.07013667,0.019651996,0.044489108,0.011199816,-0.039980873,-0.043459233,0.038749468,0.022933884,-0.036414083,-0.100433365,0.015165111,-0.05425967,0.013498479,-0.044322748,-0.0079739485,0.03958477,0.11207614,-0.0398914,0.0066452892,-0.041173678,0.1359673,0.032473776,-0.0012238879,-0.06359138,-0.0021994023,-0.06384543,-0.049338043,-0.030067988,0.08371411,0.06968616,-0.03398554,-0.0532775,0.008045306,0.034475792,-0.038358368,0.014618655,-0.046119627,0.0023584801,-0.02166452,0.070959695,0.0072043706,-0.061957363,-0.015027123,0.010520868,0.04217341,-0.08857494,-0.0886098,5.0202576e-05,-0.04644533,-0.028589241,-0.044450644,0.12543914,-0.035399776 +2.4.1.395,"The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage of the transferred glucosyl residue. The enzyme, characterized from the lactic acid bacterium Limosilactobacillus reuteri strain 121, catalyses the hydrolysis of sucrose and the transfer of the D-glucose moiety to suitable acceptors (inclduing sucrose), forming the glucan reuteran, which is typical for these strains. The enzyme forms mostly alpha(1->4) glucosidic linkages, but also alpha(1->6) linkages. The presence of maltose significantly accelerate the initial rate of the reaction. See EC 2.4.1.5, dextransucrase.",384,0.99999994,-0.030206783,-0.08763488,-0.080312565,0.014027614,0.039628766,0.013795853,-0.04329516,0.046708927,0.08951162,-0.035024494,0.024994245,0.079243116,-0.0089019565,-0.013412564,-0.11521108,-0.056203533,-0.020381521,0.024392473,-0.05704644,-0.010070558,0.14908127,-0.03591219,-0.042710837,-0.021684915,0.05951754,-0.029773893,0.033736084,-0.059984285,-0.023215337,-0.05928637,-0.042129118,-0.10245146,0.017139163,0.0017338586,0.038645692,0.10479074,0.012320132,-0.016318815,0.058474362,-0.031422798,0.013369624,-0.022537082,0.036266763,0.08451693,-0.060473196,-0.05853958,-0.08552938,0.06382988,0.010004145,0.032047924,-0.012473374,-0.06087351,-0.06079458,0.03829508,0.03496152,0.056366917,-0.0017871698,-0.00853524,0.039860487,0.019813698,0.0055987886,0.07936444,-0.026380287,-0.02476837,-0.08069858,-0.06613882,0.085950606,-0.066214256,-0.037012003,0.018339522,-0.02683096,0.0050017135,-0.010580596,0.01888363,0.04451405,-0.006879879,-0.002377389,-0.018329842,0.015654713,-0.00022556151,0.07867892,-0.006786882,0.03453075,0.067603104,-0.052997284,-0.075324565,0.04777815,-0.024038147,0.065226495,0.040622763,0.010497154,-0.040759813,-0.02686939,-0.119380236,0.014928153,0.04660789,-0.026487162,-0.030504515,0.110165,-0.061964698,-0.032054435,-0.011488783,0.029975252,-0.03558779,-0.10748827,0.0756083,-0.017465018,0.10686826,0.053512134,0.026185423,-0.0029150753,0.019808251,0.03273334,0.011642195,-0.09332011,0.02397589,0.047335606,-0.068243824,-0.08905375,-0.028970005,0.0360851,0.02606018,0.12366598,0.01038188,-0.06050143,0.04694606,-0.045175202,2.2106161e-33,0.0824695,-0.009364849,-0.0024163108,-0.05724837,-0.02900677,-0.034128975,-0.09384578,0.005101183,-0.04274833,0.045849137,-0.11675283,-0.06613227,-0.028054733,0.074298,-0.04142335,0.055764437,0.04908829,-0.020611802,0.011292769,-0.0034846081,-0.02207805,0.061319564,0.030619493,-0.018270275,0.044053953,0.06286979,-0.055513598,0.051602613,0.026767153,-0.030380672,0.026040511,-0.044975106,-0.046205107,0.07870193,0.04073,0.07069552,-0.009664184,-0.0011833258,0.086260326,-0.0031116756,0.04669701,0.05640679,0.028372722,-0.065258205,0.06257238,0.01434743,-0.0108071845,0.043987118,0.016643256,0.09926421,0.034171905,-0.0048438595,0.01087426,0.023305958,-0.046706464,0.03852724,-0.05191733,0.029190985,0.0085708285,0.05188072,0.026454177,0.07759358,0.03704349,-0.02735923,0.04672004,-0.018705226,-0.08272401,0.014488761,-0.016550822,0.055910204,-0.08917138,-0.017575989,-0.011817048,0.0298607,0.031065354,-0.043698166,-0.041089322,0.012799878,0.038234454,-0.0039728065,-0.046016496,-0.019268507,-0.014027763,-0.048173238,-0.10013081,0.053458333,-0.10140972,-0.07727599,-0.013659947,0.042339213,-0.029686157,-0.025448592,-0.055866852,0.058896948,0.02216033,-4.690749e-33,0.113288596,-0.08476217,0.09605048,0.004244927,-0.032992557,0.05783948,0.01957102,-0.0016204068,-0.009517995,-0.024058327,0.0062218476,0.030424504,-0.057326023,-0.02775465,0.053826973,0.01861862,-0.04473156,0.08864227,-0.07208682,-0.017093692,0.00012861348,0.116371915,0.004930545,-0.008455147,0.10712143,-0.062659,0.059107456,0.09042795,-0.02725567,0.018361762,0.086403094,0.002481931,-0.011527681,-0.014351565,-0.01837339,0.024038656,-0.05407577,-0.025405725,0.022675805,0.008699296,0.045759596,0.06889425,0.015586892,-0.0035695494,0.06240962,0.02405583,-0.085906915,-0.023706753,0.033762347,-0.055842217,-0.00015745655,-0.019500662,-0.02715682,0.010478096,0.062623195,0.071102664,0.030209437,0.040067594,-0.029251456,-0.030776197,-0.03590116,-0.013186392,0.029000185,-0.07686268,0.09318158,-0.0062887617,0.039519597,0.011745416,0.042376928,0.010429744,0.044896368,-0.015947722,0.0009994765,0.020886596,0.008618243,-0.0928429,-0.09421876,-0.054489855,-0.042118255,-0.049774583,0.04603658,0.042693038,0.0013810452,-0.038667005,0.023702933,-0.05332109,0.023166647,0.058869302,0.009197191,0.06812158,-0.08911776,-0.02457377,0.0055545354,0.023198843,0.059628688,-4.6054314e-08,0.013824986,0.05864252,-0.02993418,0.006879609,-0.019528445,0.03952189,-0.083886,0.0073895706,-0.044756956,-0.0383838,-0.036650714,0.108389474,-0.021221392,0.006421811,-0.01882138,-0.0038036688,-0.047466163,-0.035428483,-0.007946972,0.05159335,-0.12423647,-0.018160414,-0.122385345,0.044069365,-0.019223718,-0.11779756,0.05754442,0.08169491,-0.027883261,-0.01430895,0.005470657,0.045871254,-0.034494735,-0.053472053,0.015202593,0.013554625,-0.079692245,-0.023227893,0.07631483,0.04475111,0.0813137,0.011886089,-0.038473133,0.016023139,-0.07464949,-0.05161587,-0.045757975,-0.020961748,-0.06834848,0.092377596,0.031423748,-0.019253029,-0.091859505,0.003662055,0.008788553,-0.03846444,-0.0039932025,-0.01678962,0.013320414,-0.038867053,0.02728235,-0.030363258,0.13703482,-0.07083218 +2.4.1.396,"The enzyme, discovered in several bacterial species, is similar to EC 2.4.1.395, reuteransucrase, yet is not able to act on sucrose. The enzyme, which belongs to the glycoside hydrolase 70 (GH70) family, possesses both hydrolase and transglycosylase activities, cleaving endo alpha(1->4) linkages from the non-reducing end of maltooligosaccharides and adding the resulting oligosaccharides to the non-reducing end of alpha-D-glucan chains that terminate with a residue linked by an alpha-(1->4) linkage, forming an alpha(1->6) linkage. The enzyme is not able to form successive alpha(1->6) linkages. Unlike EC 2.4.1.394, 4,6-alpha-glucanotransferase (linear substrates/linear products), which can only act on linear substrates, this enzyme is able to act on both linear and branched substrates, and can form the branched reuteran type of alpha-glucan.",384,1.0,0.0084944675,-0.063066565,-0.062032547,0.0076086647,0.042358506,-0.013763041,-0.07709419,0.03284647,-0.0040400927,0.0016160547,0.022031626,0.017877957,-0.04896484,0.08904177,-0.086920485,-0.035358034,-0.07660279,-0.009212449,-0.011982963,-0.024279758,0.0997736,-0.027719548,-0.05892947,0.031281315,0.03018799,-0.041646425,0.02090042,-0.021392569,-0.0238954,-0.109633595,0.022091912,-0.11456808,0.007342486,-7.3996525e-05,0.033227872,0.10425965,-0.023392668,-0.031560726,-0.023809407,0.013360344,0.005212286,-0.039136536,0.027073016,0.021314649,-0.043970183,-0.066952884,-0.031892955,0.00025591487,0.019258788,-0.0033763784,-0.03139697,-0.06769687,-0.055021394,0.055812396,0.06284118,0.0008257489,-0.04424024,-0.012500714,0.026273625,0.06306688,0.035261013,0.029841878,-0.021286756,-0.013928356,-0.088278696,-0.066192016,0.053895175,-0.087114364,-0.07564072,0.008239987,-0.022375915,-0.049135327,0.024524441,0.04907657,0.08045858,-0.00055488554,-0.0052321637,0.0147994645,0.025978565,-0.022438511,0.06029747,-0.0066670715,0.028030844,0.023277601,-0.038466714,-0.037021875,0.010494892,-0.051024087,0.06111538,0.048266094,0.08216776,-0.015202165,0.04246727,-0.082773685,0.043441225,0.03494082,-0.015773585,0.018015716,0.053778227,-0.038048483,-0.026341954,0.030360278,-0.02822942,-0.046135806,-0.053091593,0.057777762,0.019063527,0.13998352,0.028012313,0.01586946,-0.0060941987,-0.014473268,0.074322335,-0.0073787193,-0.050171625,0.040697906,0.028896697,-0.05571444,-0.036133315,-0.011255005,0.057978112,0.018379463,0.14570415,0.028815636,-0.024677617,0.09601577,-0.060418528,2.5191887e-33,0.07579718,0.012946194,-0.018652113,-0.07509094,-0.03589691,-0.026314542,-0.10623199,0.02917314,-0.0646894,-0.04370757,-0.05816922,-0.06120928,-0.03363502,0.058118068,0.02476695,0.024376905,0.04043276,-0.028059367,-0.045717638,0.06334007,-0.023420965,0.054123297,0.027498126,-0.009596131,0.05237288,0.041853048,-0.0342014,0.05124698,0.024747442,-0.010038072,0.020940043,0.0027420977,-0.09709592,0.08156681,0.038823992,0.018408963,-0.02738666,-0.039086223,0.028378554,0.032523252,0.019346295,0.060007606,0.031449273,-0.10968168,0.112892725,-0.02096978,0.025965404,0.08466687,0.015170097,0.07349573,0.024870723,0.036882624,0.016328188,0.028059065,-0.0013641122,0.030038083,-0.04782546,0.032238003,0.051666237,0.036666587,-0.025293099,0.102199726,0.0051966845,-0.021404656,-0.029285338,0.01960994,-0.030730244,-0.01443196,-0.06848515,0.042153224,-0.04486594,-0.0024777919,0.049516317,-0.0032892968,0.040157415,-0.10134438,-0.032467104,0.010238093,0.02383126,-0.03538668,-0.04219948,0.00092248636,0.013678357,0.0018626193,-0.0718376,0.0048682005,-0.033458773,-0.01680458,-0.015610512,0.06476473,-0.003818717,-0.036406796,-0.069700815,0.090491146,0.014112127,-3.9504666e-33,0.10205079,-0.098223336,0.078255616,-0.028804697,-0.078987904,0.072073884,0.032985114,-0.0016939815,-0.0006852953,-0.079836436,0.07043985,-0.0011605842,0.008465515,-0.0350024,0.066782326,-0.019269709,-0.07305764,0.110045925,-0.020233152,-0.019498099,0.017632294,0.1015305,-0.036524113,0.027415797,0.13958988,-0.046983365,0.014294739,0.12820308,0.022091243,-0.028957454,-0.038406506,-0.0007101141,-0.016676527,-0.03141962,-0.031473625,0.04826992,-0.052118674,-0.017285613,0.022700122,-0.0029541429,0.05319832,0.072659485,-0.004595105,-0.01986968,0.05054219,0.094315544,-0.039439112,0.05351459,0.0394038,-0.054516084,-0.0064937337,-0.029810676,-0.023333997,0.03107376,-0.014928529,0.018002233,0.016271578,0.06932532,-0.023114309,-0.059552204,-0.020244142,-0.067729704,0.04712013,-0.044737253,0.10145039,-0.023466652,-0.01252336,-0.0012092694,0.0146574415,0.015591038,-0.04764324,-0.094758414,0.013483245,0.020432761,0.01813812,-0.016180022,-0.11382638,-0.101270966,-0.022815002,-0.04755034,0.024340814,0.06261967,0.022219598,-0.0374889,0.07868704,-0.028017089,0.039706033,0.08572171,0.0049425876,0.051213227,-0.04740686,-0.0047397017,-0.040575832,0.048225418,0.12046792,-5.1681777e-08,0.055658445,-0.019580537,-0.0024837349,-0.085941024,0.0367195,-0.020840168,-0.028292766,0.014194991,-0.013854006,-0.030924894,-0.026560878,0.10986085,0.0024046393,0.021637294,0.0030178884,-0.003283168,-0.04753155,-0.008397082,-0.006734881,0.04441268,-0.10579004,-0.09026584,-0.15948592,0.07334268,-0.08223201,-0.10412943,0.028982237,0.107447214,-0.06546521,-0.08277348,-0.0027726814,0.031819236,0.019915437,-0.0022737577,-0.048257668,0.006410892,-0.059163477,-0.0099165505,0.017634839,0.03658923,0.07484752,-0.028476879,-0.0013296403,0.0054311072,-0.034300275,-0.015877645,-0.010378083,0.005525015,-0.054949705,0.055223495,0.05619301,-0.030750005,-0.0322384,-0.089112364,0.00566163,-0.046285648,-0.0073958086,-0.027023433,0.008400396,-0.024695294,0.054527964,-0.03694678,0.16138446,-0.062123597 +2.4.99.28,"The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here). Involved in the synthesis of cell-wall peptidoglycan.",384,1.0,-0.030316144,-0.049489465,-0.07168811,-0.007625864,0.05315682,-0.048874624,-0.06254034,0.08509313,0.065727256,-0.011063861,0.010417056,0.019743958,0.048918203,0.05665082,-0.073346876,0.053849917,-0.009361462,0.0073680407,-0.0052296035,-0.037535094,0.07522006,-0.015079792,-0.043981183,-0.029587293,0.034721695,-0.015197393,0.025047557,0.037785355,0.08616639,-0.100674205,-0.0049087415,-0.051171854,0.036735766,-0.050059654,0.04580877,0.050100558,-0.051467244,0.010701281,0.052790668,0.055469595,0.021897415,-0.013386337,-0.042229313,0.00653805,0.035006203,-0.052249502,-0.09233465,0.102506064,0.04932409,-0.007752171,-0.009262508,-0.017338062,-0.05405107,0.058196317,-0.023306405,-0.0031214936,-0.111551546,0.05923757,0.034146316,-0.0009890025,0.05454184,0.09927339,0.02901301,-0.033989858,0.008395291,-0.08538271,-0.025603862,-0.025372632,0.06933045,0.037257805,-0.038327392,-0.075636454,0.022527874,0.014278221,0.1033991,0.02942502,-0.034112465,-0.0131915575,0.0012166401,-0.02221775,0.05188637,-0.022500204,0.021762729,0.05376738,0.024361078,0.02930911,-0.017901776,0.019529236,0.0067407815,-0.029933767,0.05023385,-0.048708614,-0.047427442,-0.05063359,-0.031027488,-0.040877912,0.008601474,0.047952026,0.010752534,0.006829458,-0.0031023335,0.01053527,-0.116027296,-0.086429305,-0.07577774,0.013008395,-0.010383708,0.047258582,0.09869885,-0.013694639,0.0040297764,-0.008009303,0.038454007,0.040196735,-0.003005771,0.10969992,0.008712437,-0.06051151,0.0012052872,-0.026699428,0.012631085,0.0123647135,0.00081131404,0.051217742,-0.09575901,0.0629769,-0.023805777,1.3790978e-33,-0.029135088,0.0415674,-0.013165501,0.0068763345,-0.02751888,-0.0054976977,-0.048592586,-0.006958898,-0.008921913,-0.0133691905,-0.061444607,-0.028076485,-0.0053986907,0.031121908,-0.033400275,0.0075586135,0.048457947,-0.047476947,0.030266576,0.050975896,0.044085007,0.058424134,-0.024126686,-0.020224482,0.079862885,0.09371818,0.017139796,0.015530021,0.08238507,0.015518359,-0.011957867,-0.0781091,-0.09369611,0.012112737,-0.058244083,-0.03845496,-0.04980618,-0.029083636,0.0027436207,0.023828618,-0.0071882666,0.059285298,-0.022674592,-0.06109923,0.08602466,-0.077599615,-0.002993525,0.13398644,0.04672977,0.0034308506,0.0852055,-0.012094416,0.045747355,-0.06775,-0.110820465,-0.002135923,-0.025529893,-0.0176368,0.0849595,0.06480056,0.09627046,0.04030935,-0.041299265,0.020439804,0.014989534,0.03744482,-0.043340977,0.03447432,0.016053371,0.03902312,-0.08291469,-0.028964918,0.057610665,0.058930647,-0.0051766685,-0.055640135,-0.02252607,0.053072136,0.04851917,-0.04396134,0.046686467,-0.001045346,0.03639651,-0.021542417,-0.015749993,0.025857395,-0.005185817,-0.082275204,-0.04407898,0.10165303,0.050331812,-0.073403545,-0.06601932,0.035065796,-0.016461357,-3.0316209e-33,0.10706608,-0.10641684,0.0078422725,-0.03822979,-0.07562574,0.06911497,0.00052572245,-0.0040870924,0.08225957,-0.0042294287,0.0491417,-0.0022648901,0.01685277,0.008057222,0.051819358,0.03794203,-0.051870007,0.033348177,-0.06466596,0.029854868,-0.053303942,0.042138286,0.00080408936,0.0044797165,0.029322414,0.029715637,-0.0004795047,0.00056886615,0.028314853,0.03693136,-0.024390955,-0.007958443,-0.09373148,-0.082634345,-0.06902749,0.01807283,-0.068472035,-0.061178464,-0.045394287,-0.022635711,-0.017514216,0.053406674,-0.04122179,0.06763297,-0.025419734,0.108795635,-0.050261963,0.0013118865,0.034731817,-0.06522086,0.023208255,-0.047942806,-0.0074944273,0.050037805,0.008895714,0.042143922,0.02181964,0.04047628,-0.012295122,0.014994656,-0.030607956,-0.061586667,-0.053772207,-0.053009637,0.06679897,0.08175,-0.026515195,0.06378285,0.04625397,-0.03338424,0.102036156,0.04273617,-0.010524527,-0.021772524,-0.04014393,0.0759887,-0.048246436,-0.096554846,0.0007451822,-0.06704388,-0.060208783,-0.025678566,-0.047443837,-0.07826681,-0.0035818995,-0.090751655,-0.004127448,0.16946602,-0.0145807145,0.042977963,0.051234037,-0.022918224,-0.024091005,-0.02895887,0.13154168,-4.283429e-08,0.024813617,-0.093486644,-0.0017894609,-0.041761167,-0.05402979,-0.04398772,-0.031163044,-0.011921398,-0.010410143,-0.0020508505,-0.01980532,-0.01285868,-0.014229046,-0.06462945,-0.020492537,0.087847635,0.03484272,0.083180346,-0.012970291,0.01921955,-0.12392993,-0.0028930146,-0.07105813,0.0005825305,0.080929264,-0.12883937,0.013804568,0.031071927,-0.056751218,0.0058341795,0.0016395695,0.014361698,-0.046702966,-0.04454231,-0.041717872,0.037792824,-0.01308098,-0.029351898,0.0007747136,-0.047250666,0.069749445,-0.0031057748,-0.082432374,-0.015141924,-0.012288466,-0.010348988,0.013608202,-0.03892825,-0.04591029,0.011528277,0.0039394097,-0.025081173,0.020972613,-0.06629954,-0.030025277,0.0049332962,-0.044704594,-0.049386963,0.04162921,-0.08750068,0.024801498,0.059561975,0.21543424,-0.05453054 +3.1.1.122,"The enzyme, which is inducible in the soil bacterium Nocardioides sp. (strain SG-4G), catalyses the degradation of the fungicide carbendazim. Following hydrolysis of the carbamate ester, the carbamate decarboxylates spontaneously.",384,0.99999994,-0.038922846,0.03274872,-0.058206525,-0.0017520504,0.05362176,0.068324484,-0.0931385,0.043429546,0.04505783,-0.036764134,0.01376216,-0.033782486,-0.06093681,0.025201524,-0.09342554,0.025398193,0.0056195133,0.039630156,0.0047148415,0.019326553,1.9712577e-05,0.08324698,-0.0400466,0.002314643,-0.008569871,0.0052030804,-0.013612906,-0.046312556,-0.0021313697,-0.13012369,0.12481571,0.069616854,0.077482566,0.01197284,0.07532877,0.03051001,-0.045129076,-0.0932058,0.042836044,0.03391247,-0.005489496,0.018998396,-0.017014043,-0.037285652,-0.010847122,-0.042718194,0.032807823,0.01523286,-0.006889094,-0.08452071,0.017407294,-0.017610302,-0.017867675,-0.023408469,-0.023878947,-0.03832019,-0.02435288,-0.02570856,-0.064972535,0.036489356,0.090377174,0.05173665,-0.001753978,0.009900707,0.0022614626,0.009491544,0.044466633,-0.0283213,0.052056286,0.024902448,-0.041544665,-0.07963739,0.06058233,-0.033141408,-0.04308207,0.0020613943,-0.0588645,0.008023724,0.08138513,-0.05388306,-0.0071101985,-0.028388523,0.06845804,0.035425354,-0.004319929,-0.039950524,0.028210875,0.023840237,0.14140426,0.014105182,0.031769015,0.0008570379,0.018802717,0.040278748,-0.12951526,0.029004265,-0.012988908,-0.024005601,-0.021460142,-0.020709256,0.030178407,0.036244117,-0.059734654,-0.09207785,-0.032104205,0.065862186,0.0057205195,0.0516456,0.06508019,0.035768647,-0.040766273,0.04961991,-0.0051193195,-0.027386159,-0.040557865,0.0059319213,0.08244551,-0.061945114,-0.09104354,0.057818983,0.0101021975,-0.07081888,-0.03262943,0.009573012,-0.019946685,0.1426965,-0.06947386,1.1371538e-33,0.05820622,-0.0188895,0.049682263,-0.07109123,0.065779775,-0.06187868,-0.065793835,0.056901675,-0.04074844,-0.03873274,-0.058845438,-0.07368909,-0.034489498,-0.004386965,0.0060290312,0.027859647,-0.07144418,-0.059990365,0.06746064,-0.0056908904,0.014000467,0.062215228,-0.09874546,0.03945057,0.05420111,0.10906756,0.00230328,-0.0416759,0.04808611,0.0048558707,0.05052828,-0.08304267,-0.12225777,0.033280678,0.05754599,0.011138302,-0.061323356,0.03972262,-0.04011785,0.044978928,0.026691958,-0.0040615695,-0.011844363,-0.09714726,0.09653803,-0.07667916,0.04463965,0.12347088,0.04338766,0.026555117,0.059173897,-0.026861759,0.051001813,0.044317458,0.00052235596,0.09560752,-0.059562378,0.0014688831,0.018614253,-0.012444869,0.03101421,0.02467614,-0.0695124,-0.0052110264,0.036817186,-0.0446508,-0.042799253,-0.010537097,0.009377049,0.035129607,-0.09819755,-0.016966805,0.034284253,0.045648918,-0.048062515,-0.016795088,-0.07725364,-0.0068296017,0.04659911,-0.015036957,-0.033858538,-0.0053968756,-0.009112517,-0.071341835,-0.020692797,-0.010292377,-0.028887348,-0.03215941,-0.014313873,0.05485147,0.058343902,-0.06343361,-0.07493472,0.014970816,-0.01144403,-2.1359919e-33,0.08470274,-0.04317313,0.018838877,0.04758297,0.0062050647,0.0018980033,0.0018417735,-0.004041936,0.028289909,0.02568945,0.018440742,0.028907793,0.057326686,-0.02461965,0.036499687,0.039584782,0.044940196,0.026688654,-0.08517057,-0.09587493,-0.044090793,0.10427449,-0.037965816,0.0009319714,-0.0065015275,0.04661858,0.015463698,0.09650839,0.0791499,0.056574147,0.0799784,0.051927313,-0.036293935,-0.10125409,-0.04670896,0.015959566,-0.08829573,0.047538254,0.024343958,-0.028516395,-0.013602843,0.016582143,0.015677955,0.047911733,0.037300944,0.027953327,-0.0708815,-0.0543093,0.093607746,-0.06249822,0.03484356,0.0076784696,-0.023700086,0.037437636,0.028136188,0.038192727,0.014086965,-0.046548788,-0.030315021,0.029282236,-0.004009624,-0.0015599198,0.027404357,-0.010100506,0.029503863,0.0043211775,-0.037565336,0.09559939,0.059433382,-0.06027021,0.054272056,0.080549404,-0.038956694,0.050207704,-0.080476396,0.03340352,-0.053261753,-0.03900377,-0.021900803,-0.10047909,0.032610178,-0.064935304,0.044438783,-0.07676805,-0.028549826,-0.05271282,0.020413863,0.037798755,0.07799914,0.055006683,-0.03446281,-0.017429203,-0.016441371,0.058268614,-0.004897367,-3.377977e-08,-0.028831497,-0.04283205,0.04230967,-0.079675674,-0.027736504,0.041672632,0.063814,0.051799823,0.019069761,-0.05895035,0.017544962,0.047350246,-0.06864075,0.04471916,0.055928603,0.044121757,-0.033951018,-0.029052008,-0.068474516,-0.040379427,-0.025629662,-0.012191692,-0.10078614,0.024497025,0.031823948,-0.05335536,0.07731463,0.0026328021,0.06575713,0.02578861,-0.0005186133,0.046648707,0.059555594,-0.0058295284,-0.10190417,-0.0018718294,0.020079358,-0.057925057,0.022706814,0.06266211,-0.008843592,-0.00059454184,-0.09711886,-0.04560791,-0.026540304,-0.03445718,0.0028198313,0.007457299,-0.055270832,0.019811219,0.036546845,-0.0072499276,-0.14015295,0.08648545,-0.05095874,0.01223696,0.0020285153,-0.021406723,-0.0031795446,-0.07193182,-0.069103345,-0.006035594,0.15945871,-0.010528268 +3.2.1.221,"The enzyme, present in mycobacterial species that produce 3-O-methylmannose polysaccharide (MMP), is involved in recycling and biosynthesis of the polymer. The enzyme has been shown to cleave substrates in the range of 11--14 mannose residues.",384,1.0,0.0155551145,-0.055513725,-0.016510483,-0.06979205,-0.02014129,0.014903438,0.051966663,0.036696386,0.021975702,0.0597557,-0.01073481,-0.025078129,0.009527473,0.021121426,-0.08707252,0.054409046,0.03460034,0.017927686,0.07037617,0.05716272,0.14252692,-0.01881303,0.01670823,-0.07534754,0.07556045,0.0015526051,0.043104276,-0.04960062,-0.008084401,-0.06832867,-0.030765198,-0.044235066,0.06409052,-0.0746792,0.15864323,0.08915989,0.009165191,-0.07038597,0.08077685,0.014976582,0.063892566,-0.0031021582,0.027977,-0.075407594,-0.04193598,0.011448428,-0.06260137,0.023381112,-0.051265635,-0.0072571705,-0.012166623,-0.036388703,-0.02177139,-0.02264512,0.053425066,-0.039915632,0.01830251,-0.022372304,-0.0022701554,0.04165919,0.024881477,0.0013351867,0.026787693,0.007000992,0.01659328,-0.07559688,-0.011110268,-0.019465558,-0.006059436,0.016565697,-0.10283495,0.007949091,-0.08033856,0.009150979,0.06278657,-0.04762739,0.027069962,-0.07491314,0.02352538,0.056138996,-0.03654599,-0.005296089,-0.005097452,-0.04820649,0.0040246183,-0.0640666,0.091062255,0.029745514,0.02510934,0.028053725,-0.034543294,-0.00077151373,0.023170032,0.00084586523,-0.050410815,-0.042036332,0.0507888,0.03451537,0.08027904,-0.038131334,0.0048128725,-0.017542953,0.045957442,-0.06923644,-0.08117027,0.019835353,-0.022058811,0.045049872,0.09304103,0.06676648,-0.03393517,0.08687466,-0.030260779,-0.009501146,-0.011307015,0.0975576,0.077659234,-0.080069534,-0.04465933,-0.0061790724,-0.04170622,-0.07676075,0.03396425,0.013728458,-0.07743297,0.04580191,-0.0156121645,-1.2145345e-33,0.01949657,-0.047839426,0.03509605,-0.041464157,0.05692686,-0.045457646,-0.00998602,-0.036243476,-0.070888594,-0.05810822,-0.085611545,-0.10815184,-0.0017272751,0.102460615,-0.103328064,0.04954162,0.00607701,-0.007704625,0.07241452,0.02756549,-0.03672619,0.005846605,0.025752744,0.040527813,0.07497351,0.025582418,-0.02340484,0.0479984,0.04923899,-0.012876191,0.09989983,-0.043726258,-0.1008124,-0.064239286,0.026526595,0.0057756416,-0.04756744,-0.04120857,0.009759617,0.03504967,0.016513089,0.00702797,0.06775562,-0.03688887,0.024980988,-0.017688857,-0.0025954465,0.024491698,-0.041948643,0.037221484,0.05397541,0.0041398033,0.016457237,0.0068585505,-0.03681005,-0.010476999,-0.062106475,-0.020824661,-0.0020754342,0.042109534,0.0334219,0.02328987,0.00086217775,0.051519513,0.007186342,-0.029635172,0.0012357349,0.06682892,0.060965776,0.028737241,-0.037460614,-0.06373359,-0.020343386,-0.031829588,0.05242355,-0.02589265,-0.08795992,-0.01064764,0.036204904,-0.026709542,0.10112005,0.060633358,-0.047172107,-0.107235484,-0.072451755,-0.04960173,-0.05927028,-0.057768553,0.0023440812,0.02203501,0.009550816,-0.06265503,-0.015494644,0.092570975,-0.0790342,-2.629971e-33,0.13212174,-0.10816673,0.12136098,-0.06102172,-0.057648342,-0.04976622,0.07975654,0.026681624,-0.024059845,-0.0040542586,0.06781319,-0.020238137,0.051341448,0.007769683,0.015373359,0.021565458,-0.026756085,0.08653939,-0.04177098,-0.036936108,-0.0030881846,0.04767308,0.048906755,-0.03220398,-0.025634618,0.006779976,-0.06654698,0.02441242,0.03136231,0.0412599,0.0017542611,-0.024032148,-0.020932386,-0.079766825,-0.014128849,-0.057487905,-0.091337,-0.046993624,0.07641018,0.023705915,-0.010367318,0.06306405,-0.029102651,-0.011571707,-0.021624235,-0.022214623,-0.057301283,-0.013239816,0.06153725,-0.028498009,-0.06972137,-0.048466973,0.046060603,-0.022535404,0.009607566,0.07970901,0.028255615,0.015836367,0.028449144,-0.05431308,-0.08106665,0.006608021,0.06740755,0.003147705,0.08555461,0.14202036,0.0010654407,0.0013459949,0.023502694,-0.05675004,-0.0023466973,0.02951225,-0.053365316,0.032255825,-0.018261686,-0.056592062,-0.106785946,0.060165018,-0.04798177,-0.0141858095,-0.006972231,-0.05124148,-0.027390318,-0.075642616,-0.03128547,-0.09435905,0.05314211,0.042529393,-0.0335476,0.052419946,-0.031267785,0.05466864,-0.031139102,0.04848453,0.05525082,-3.4321655e-08,-0.016817518,-0.036579926,0.018939454,-0.038632203,-0.014125655,0.036713753,-0.059094094,-0.041434284,0.022331743,0.023604872,0.06046913,0.052658696,-0.023856195,0.011124984,0.045997974,-0.028164754,-0.06820705,-0.09418592,0.012903073,-0.03573096,-0.09140721,0.03665474,-0.0010628272,0.09845836,0.021083144,0.008155329,0.031514976,0.09835345,0.009667113,0.01850827,0.02194447,0.12279579,-0.011360665,-0.06970553,-0.09116521,0.013967581,-0.055350013,-0.07126745,0.023968216,0.027409293,0.08572777,-0.010018017,-0.00834619,-0.0102806445,0.00773834,0.049243227,-0.064071804,0.03910307,-0.08562675,0.06629651,-0.025835296,-0.004680418,-0.10355494,0.02894574,-0.0066015655,0.018426357,-0.055118017,-0.005079292,-0.00058246433,-0.041590236,0.032051206,-0.04079028,0.1183395,-0.08948425 +3.2.1.222,"The enzyme is an endo hydrolase that hydrolyses the beta(1->4) bond in funoran, a polysaccharide produced by red algae of the genus Gloiopeltis. The enzyme from the marine bacterium Wenyingzhuangia aestuarii OF219 acts on agarose with a higher efficiency (cf. EC 3.2.1.81, beta-agarase), but binds funoran preferentially.",384,1.0,-0.041304905,-0.020006731,-0.09413262,0.023959156,0.009531661,0.038190518,0.025631089,0.030846426,0.008746833,-0.027162846,0.0145406695,-0.055339634,-0.12478319,0.06602778,-0.08640353,0.03191011,-0.041441683,-0.052758347,-0.036297303,-0.021757575,0.10999106,0.039301626,-0.061407477,0.013383239,0.029036216,-0.028057957,-0.0028588227,-0.065762356,-0.012476829,-0.045523506,-0.026015779,-0.045981158,0.1200836,-0.025383877,0.06354508,0.06918593,-0.051854897,-0.08681359,0.03244802,0.017207868,0.0741454,-0.0075191404,0.03262955,-0.017983295,-0.027578661,0.03671803,0.032672107,0.022811683,0.04422262,0.043185875,-0.063600935,-0.13208982,-0.09799328,-0.015921928,0.045837756,-0.01995929,-0.00064747717,-0.08372579,-0.078550585,0.0082278615,0.10289355,0.011338451,-0.03810864,0.02858681,0.002503707,-0.048464153,0.035366185,-0.07406383,-0.05482541,-0.037634045,-0.03563558,-0.052325822,-0.038086586,0.044924892,-0.01348162,0.013265709,-0.056810573,0.01937659,0.059317954,-0.0016729712,0.066016965,0.008784972,0.0405943,0.048714552,0.009493144,-0.017658371,0.024660429,0.017441422,0.0806669,0.017595286,0.0035801644,-0.023267392,-0.03590538,-0.056701425,-0.018615153,0.0183869,-0.028031195,-0.058957316,-0.0030807129,0.019180918,-0.02797248,-0.011072805,0.03510304,-0.12982717,-0.06191332,0.07973727,-0.005416483,0.086517885,0.06857481,0.020848097,-0.05909482,0.0119174905,0.057519488,0.006268914,-0.03482192,0.067977116,-0.00429179,-0.0379104,-0.055574562,0.018217137,0.043675616,-0.077682085,0.075025655,0.09509628,0.012329166,0.022541523,-0.11153644,1.514566e-33,0.07139272,-0.028723441,-0.013965749,-0.052722543,0.055629186,-0.00859521,-0.04660161,-0.037203267,-0.10277706,-0.014466908,-0.070754535,-0.012683332,0.004509973,0.04647728,0.030850926,0.04843672,0.006793484,0.028466148,0.04035692,0.019667799,0.034727536,0.038329884,0.0012901963,-0.08166981,0.012630919,0.06859011,-0.028924812,-0.024555728,0.07805886,0.004594647,0.061949775,-0.06969059,-0.08074973,0.042786162,0.029887836,-0.0048398133,-0.067084804,-0.07570661,-0.04022412,0.011753134,0.0392434,0.039830744,0.002147101,0.005649847,0.07131391,-0.08605741,0.00027835075,0.08248409,0.07862929,0.08756003,0.011428129,-0.053793352,0.036771704,0.049873147,-0.07351185,0.055553958,-0.034730088,0.044069853,-0.031774327,0.02243854,-0.013592005,0.036018968,-0.008083417,-0.0521073,-0.031186951,0.028772894,-0.008138584,0.016121991,0.040493503,0.05520721,-0.040108986,-0.033295177,0.009204912,0.02100579,-0.053774025,-0.070998974,0.0074019074,-0.04316234,0.009108753,-0.0044938526,0.025784109,-0.012351325,0.04542313,0.022347337,-0.12439823,0.018742668,0.023465741,0.0052458826,-0.0112459995,0.042114988,0.043294605,-0.07652345,-0.034410555,0.04675489,0.030681709,-1.6072358e-33,0.1273145,-0.14786832,-0.0207748,-0.06461908,-0.023561424,-0.027972441,0.04409598,-0.024854997,-0.023400983,0.00929914,0.077264845,0.0021139032,0.060489763,-0.036169115,-0.018228715,-0.053076953,0.075627595,0.04362191,0.007844841,-0.05334115,-0.026569897,0.07236244,0.087669924,-0.04920626,0.052084547,0.0029667013,0.021709938,0.095181726,-0.04147116,0.039352745,-0.048134536,0.005705529,-0.018036464,-0.09314809,-0.039552506,0.043308444,-0.03809117,-0.02136126,0.092752405,0.009092775,0.05890922,0.017221346,0.062356506,0.012843751,0.05912122,0.10993302,-0.08254885,0.017984405,-0.0068208766,-0.07635258,0.038770698,0.004340788,0.009130492,0.048086453,0.032491747,0.028724572,0.017644443,0.035087086,-0.08294121,-0.038866043,-0.0058632656,-0.027670689,0.054726236,-0.015970634,0.053264182,0.08672598,-0.073392585,0.03922294,-0.03185214,0.07052473,0.027956389,-0.0069935517,-0.05358836,0.109495714,-0.016924417,-0.044790115,-0.09084234,-0.07380003,0.028582716,-0.05491864,-0.031538513,0.0068584727,-0.023410082,-0.02463928,-0.0068297214,-0.123187065,0.055424362,0.124440394,-0.03339681,0.058892805,-0.037239,0.0042914385,-0.009150057,0.05389665,0.073524185,-3.8326522e-08,-0.0071894787,-0.025450626,0.030459512,-0.0492272,-0.041452695,0.01489411,0.041928478,0.033658925,0.018085847,-0.086711586,-0.007326513,0.055429935,0.0058956873,0.02066278,0.05594091,-0.0061379285,-0.005813442,-0.017710578,-0.035193995,-0.057975687,-0.04508355,0.012039988,-0.086711,-0.027825596,-0.09588824,-0.030166626,0.07275113,0.07865086,-0.016146796,-0.037986934,-0.0068501383,0.06858633,-0.014251302,-0.018797452,-0.055032473,0.069868885,-0.05091323,-0.02551568,0.019503625,0.049302205,0.045818835,0.0051263026,-0.009707308,-0.020916045,0.002812922,0.049348272,0.056101203,-0.009132088,0.033657797,0.020477798,0.11071738,-0.01761291,-0.077635415,-0.021633703,-0.064372525,-0.044173464,-0.010427159,-0.06795463,-0.033111744,0.060449462,0.016290773,-0.0035609694,0.17366388,-0.027308386 +3.2.1.223,"The enzyme, characterized from the bacterium Bifidobacterium pseudocatenulatum, specifically hydrolyses beta-L-Arap-(1->3)-L-Araf disaccharides from the non-reducing terminal of arabinogalactan using an exo mode of action. It is active with arabinogalactan-proteins (AGPs) containing type II arabinogalactans such as gum arabic AGP and larch AGP. The enzyme can also hydrolyse alpha-D-Galp-(1->3)-L-Araf disaccharides (cf. EC 3.2.1.215) with a much lower activity.",384,1.0,-0.05313365,-0.09636015,-0.028733078,-0.028751625,0.045291033,0.016226506,-0.008265811,0.017829604,0.06933847,0.019475982,0.023554197,0.040849075,-0.04520535,0.03808692,-0.048289355,0.085907996,0.009247024,0.04362797,-0.003059708,0.0098139895,0.087323345,-0.002948085,-0.05973024,0.0016825377,0.06677817,0.019450756,0.039684974,-0.022076184,-0.049431033,-0.04093875,0.018782606,0.005103913,0.13774996,-0.066115774,0.013541731,0.1249788,-0.055877138,-0.043292213,0.07660294,-0.05595431,0.07148128,0.010853719,0.045663897,-0.105745934,-0.032320596,-0.019745719,-0.0742509,0.045800403,0.07649958,-0.044805918,-0.040850475,-0.06087591,-0.03892707,-0.006448467,0.023485275,-0.05666219,-0.014936953,-0.055999175,-0.006156832,0.025529195,0.029973801,0.06296317,-0.015272373,0.008239624,-0.044429783,-0.036335632,0.039416943,-0.0744969,0.002096591,0.0023055198,-0.07755133,0.0052453596,-0.03721897,0.032947857,0.042297825,-0.053259473,-0.039031558,-0.041834347,0.020811219,-0.01766495,-0.012090796,-0.024867767,0.0033261587,0.03960915,-0.027539788,-0.08055074,0.0359118,0.026590025,-0.004150089,0.025723157,-0.013363717,0.010200752,0.010112685,-0.017048022,-0.00022026576,0.004911865,-0.04531857,-0.028135428,0.0065296916,-0.013332907,0.0074602817,0.028240886,0.06860179,-0.13497613,-0.04755148,0.013944074,-0.0067184465,0.07066798,0.058576986,-0.004872452,0.014377693,-0.009776411,0.0011651061,-0.035929665,-0.08374232,0.06313048,-0.009874251,-0.16012286,-0.045664217,-0.020996476,0.015030315,-0.059444692,0.10556818,0.07916335,-0.0111121135,0.07193287,-0.06706328,1.82581e-33,0.059035905,-0.09149937,0.03365793,-0.048253402,-0.006907942,0.0100970445,-0.071771026,-0.016564941,0.022515187,-0.006790109,-0.03235731,-0.027445795,0.035928838,0.07110603,-0.008575297,-0.011396772,0.012173355,-0.050899614,0.07519774,0.048100594,0.03189426,0.0469081,-0.017272403,0.010592387,0.09019838,0.04229767,0.0072831935,-0.029564466,0.05375622,0.020305742,0.05392985,-0.05518568,-0.16695566,0.027348695,0.038875744,0.035816446,-0.055059444,-0.04005643,-0.004846508,0.023467086,0.02570944,0.022282306,0.002379897,0.0015106753,0.0603879,0.005584714,0.007628576,0.087998234,0.029665576,0.12814169,0.07247195,-0.013740143,0.05896473,-0.029093875,-0.03970249,0.026653264,-0.014591478,0.046156265,-0.037594285,0.052046977,-0.0046333233,0.046304654,-0.016076036,0.01315229,-0.045196015,0.044746928,-0.016898295,-0.051221106,0.04757398,-0.034729857,-0.051048424,0.0038999282,0.037617955,0.06023291,0.0066975905,-0.07132302,0.026834449,0.031417545,0.023250245,0.05307597,-0.018646946,0.03160744,0.050272204,-0.02033646,-0.1165327,0.07705972,-0.012427257,-0.02360627,-0.018984392,-0.02265408,0.04830399,-0.0054731164,-0.08256351,0.14218754,0.028985685,-3.237297e-33,0.10224799,-0.11100644,0.029269163,-0.016904887,-0.015816018,0.010980139,0.082363665,0.045155637,0.06289366,-0.014930271,0.0841537,-0.011035097,0.032435603,-0.077350356,0.05971655,-0.034309074,0.02309616,0.04457336,-0.10877352,0.035418905,-0.04666194,0.09269637,0.078465685,-0.022843758,0.034820475,-0.0023881986,-0.020798903,0.08244947,-0.021512251,0.018123137,0.07243157,0.07320589,-0.08823068,-0.063360594,-0.08647588,0.016248405,-0.11068341,-0.0076999776,-0.021071073,-0.013647415,0.02552358,0.106768,0.005556558,0.020506192,0.0059371055,0.082236916,-0.024500914,-0.0003595807,-0.024426276,-0.09936097,-0.05654998,-0.014219659,0.04776465,0.06920508,0.018061165,0.05192395,0.018242838,0.10972607,-0.100305066,-0.05815769,-0.038770627,-0.061992943,0.13169819,-0.03427923,0.04754272,0.04526165,0.017145755,0.010104742,0.021244004,-0.008696732,0.044221405,0.019454457,-0.051098917,0.046590284,0.04646921,0.071762845,-0.094632335,-0.07427529,-0.030538138,-0.056801233,0.03105735,0.04571308,-0.09093008,-0.06729174,0.007227306,-0.030745957,-0.05453171,0.07533749,-0.029687494,0.060441807,-0.019593416,-0.036327578,-0.061929516,0.006549929,0.022883484,-4.0817824e-08,-0.031193301,0.0022098045,-0.0019112782,-0.0652595,0.00043220006,0.022179047,-0.015026813,0.015876586,-0.0109717455,-0.01757236,-0.017086597,0.056865767,-0.07414128,-0.013255733,-0.0006360351,-0.027293243,0.00151187,0.005256742,-0.00057196047,0.0050036246,-0.0857769,-0.036208455,-0.15807515,0.032536406,-0.023756433,-0.050050374,0.034598242,-0.014083446,0.01472973,0.02107001,0.017465828,0.056155134,-0.040566027,-0.04529069,-0.058786172,0.013536617,-0.05512304,-0.006881642,-0.047303434,0.003624218,0.07855505,-0.039185103,-0.050402287,-0.051213395,-0.0596445,-0.012373066,-0.024542619,0.033758435,-0.021572448,0.028531697,0.103950575,-0.033994332,-0.06535594,-0.012137863,-0.022456577,-0.0106514385,0.027092114,-0.10460887,-0.017072886,0.02419491,0.00069323234,-0.052713122,0.09534847,0.02296096 +3.4.21.123,This bacterial pepstatin-insensitive carboxyl proteinase has been isolated and characterized from Bacillus sp. MN-32 and from several Burkholderia spp. Kumamolysin from Bacillus sp. MN-32 exhibits a Ser278/Glu78/Asp82 catalytic triad. The enzyme is a type example of peptidase family S53 in the MEROPS Peptidase Database.,384,1.0,-0.026975526,-0.032337476,-0.06324426,0.0216936,0.039697334,0.12406692,-0.12649834,0.060365193,0.009831287,-0.05438286,-0.0025008405,-0.042589933,0.04446471,0.019877983,-0.025368635,0.027287915,-0.057460297,-0.03269053,0.037445217,-0.017455295,0.039274942,0.05213374,0.012891172,0.054869995,-0.024740117,0.04479662,0.08657234,-0.048931275,-0.060909662,-0.09361966,-0.084365,-0.1067135,0.09777488,-0.0379007,0.140718,0.023033084,-0.021249322,0.024307974,0.09469174,-0.043266084,0.0310091,-0.019324379,-0.011250982,-0.06257918,0.03710582,-0.0044615823,0.016703883,-0.00192458,0.06372709,-0.012905359,-0.06605714,-0.02639635,0.004413192,-0.021086104,0.016471265,-0.04283308,-0.0547555,-0.056675874,0.050884858,0.014224051,0.062975734,-0.02572297,0.072003305,-0.06485067,-0.016719962,-0.08699596,0.01063631,-0.028836675,0.050715737,-0.007712322,-0.017166032,0.008926037,-0.031674076,0.104401514,0.04667158,-0.012001913,-0.049378708,-0.02109695,-0.005160362,-0.032724865,0.027027398,-0.018556438,0.03805161,0.08275704,-0.016855758,-0.041330826,0.0148186,0.08874182,0.07014987,-0.017510267,0.018662214,-0.024705438,0.035010047,-0.053524103,-0.041114528,-0.044094626,-0.033008985,0.01363252,0.020786019,-0.012428649,0.01530666,-0.024219751,-0.038226437,-0.0523056,-0.010661212,0.034590237,0.005075467,0.06777994,0.12277797,-0.010781815,0.014597231,0.029754335,0.030140184,-0.055529512,0.0014703134,0.037812293,-0.027228864,-0.06638895,0.010313171,0.018608227,0.07390294,-0.01413498,0.014516861,0.05651883,-0.02173206,0.053215045,-0.10047098,5.217034e-33,0.06747799,0.01559065,0.07194658,0.0023002988,-0.022019006,-0.050193157,-0.04464718,-0.025343807,-0.024586873,-0.079274565,-0.092185706,-0.059277296,-0.020005532,-0.022807036,-0.04090889,0.05186786,-0.05270671,0.026764028,0.04090838,0.0012602838,0.0026980243,0.059542656,-0.06709968,-0.009658572,0.09014589,0.027124302,0.07916777,-0.028424753,0.12255881,-0.013854816,0.0011152383,-0.0470153,-0.08322905,-0.05139417,0.049796056,-0.08112564,-0.06602828,-0.000987501,-0.057126068,0.037209425,0.008539707,0.05310745,-0.049206976,-0.043326735,0.038757272,-0.01739536,-0.041728005,0.033879887,-0.007622076,0.043965265,0.043254215,-0.02711672,0.04417188,0.024039464,0.0022132033,0.023663722,0.047338843,0.01822455,0.018805498,0.06169895,0.07306878,0.026473273,0.04588928,-0.007260335,0.028973017,-0.012760653,-0.053024266,0.05899916,-0.01350666,0.09915727,-0.04162452,0.0043254695,0.048730586,0.04007193,-0.06800955,-0.14538231,-0.059278864,0.012318966,-0.02268493,0.07275534,-0.010910467,-0.023106256,0.003967267,-0.041018333,-0.06602246,0.02513802,-0.040361006,-0.07672983,-0.051392216,0.04071187,0.032396544,-0.09295094,-0.052934796,0.13746303,-0.11535184,-5.0404647e-33,0.06896736,-0.073030345,0.11182608,-0.042735163,-0.09564844,-0.004486907,0.007162002,0.02605571,-0.013057211,-0.013746977,0.055972192,0.018693719,0.114175975,0.036151372,0.05191727,0.049403407,0.0014637235,0.0849777,-0.03305066,-0.02397814,-0.041704223,0.023459895,-0.009963312,0.08732362,-0.0054096933,0.039697543,-0.028350191,0.106284134,0.03518299,-0.032458194,0.027616875,0.0043248516,-0.03987144,-0.046367526,-0.10959168,0.0044397954,-0.04779699,-0.014902469,0.05048596,-0.03603032,-0.05358572,0.03950056,-0.037614323,0.084668405,-0.0005237344,0.0332228,0.059427105,-0.0015255132,0.061999645,-0.0686547,-0.015504378,-0.024627388,-0.064332016,-0.061300796,-0.036306534,-0.009036324,-0.001103837,0.08814713,-0.022243017,-0.0004443111,0.008752694,-0.06082824,0.020882992,0.04550743,0.027792547,0.08916793,-0.04574114,-0.0047369595,0.108973965,-0.063034296,-0.029373411,-0.042396523,0.018615555,0.09171829,0.02024899,0.031733382,-0.03761196,-0.030556977,0.028258909,-0.0048643025,-0.016300268,-0.058236815,0.025048051,-0.008090945,-0.018226014,-0.03656556,0.05333454,0.046470158,0.0074784774,0.09012196,-0.031067813,-0.024711922,0.036695044,0.08235488,-0.020088634,-3.7211134e-08,0.08867597,-0.11928682,-0.007429372,-0.050682947,-0.054285895,0.0005802669,-0.10441784,-0.011391288,0.0052906643,-0.074163824,-0.0136812525,-0.0396796,-0.064207554,0.030012293,0.012715903,0.029046325,-0.02914814,0.0647005,-0.0017312965,0.03216883,-0.06531405,-0.010393905,-0.037859555,0.07883081,-0.0125010945,-0.030326487,0.017102927,0.10922757,0.03275654,-0.06777525,-0.036898777,-0.004417033,-0.03439831,0.018554054,0.0046397983,-0.009641337,-0.067672126,0.006492697,-0.014288406,0.044226844,0.11236318,-0.060412556,-0.08308885,-0.038682066,-0.05576046,0.030738067,-0.02209501,0.03647063,-0.0017088125,-0.012379071,-0.016707607,-0.028264599,0.01409777,-0.019916225,-0.06223734,0.0615617,0.014898242,-0.068113364,0.0142765865,-0.035326835,0.049740277,-0.012456513,0.15268369,0.010474358 +3.4.26.1,"The cleavage site motif is typically referred to as CaaX, where the letter a represents any amino acid, rather than alanine, and X represents the C-terminal amino acid of the target protein. The enzyme has been found in the yeast Saccharomyces cerevisiae and homologues exist in humans and several other species. Although the cleavage site is similar to that of the metallo-peptidase Ste24 endopeptidase (EC 3.4.24.84), there appear to be specificity differences in the proteins hydrolysed by these two enzymes, with amino-acid substitution studies indicating activity of the yeast enzyme towards substrates with a hydrophylic residue at (P1') that are not hydrolysed by EC 3.4.24.84 [4].",384,1.0,0.02476453,-0.06137581,-0.061894804,-0.05087648,0.09662235,0.030735686,-0.00644086,0.06607096,0.061123017,0.020026013,0.072955504,-0.00998099,-0.059504908,0.05665244,-0.010846533,-0.057316788,-0.07859416,-0.048480995,0.03578177,-0.01050173,0.11270676,0.05417749,-0.017735923,-0.026019953,0.009656725,0.02653769,-0.0058892174,-0.06334476,0.047548573,-0.035642553,0.039372716,-0.05344863,0.065897375,-0.054404836,0.030234475,0.030596368,-0.021422291,-0.061418727,-0.0004782338,-0.022462677,0.075221,-0.0031690614,-0.055745445,0.019992562,-0.0047377073,0.002053826,0.023514368,0.017854054,-0.037130106,0.05112003,0.031186603,-0.14469312,0.027706135,-0.026154408,-0.035165094,0.037065454,-0.041859273,0.0018690331,0.043568827,-0.0019254973,0.010919761,0.008495497,-0.012320934,-0.008764973,0.04508434,-0.085965596,0.039779782,-0.055269837,0.04492164,-0.0037959665,-0.053317387,-0.04964762,-0.08467055,0.03670749,0.033744138,0.09792084,0.03725596,-0.1049325,-0.03015958,-0.05827429,0.026815228,0.010713044,0.09689613,0.037169244,0.070581116,0.008417755,0.029534467,0.02864984,0.07580871,-0.0042316546,0.05006005,-0.029655764,-0.021224242,0.06830868,-0.006105804,0.04660312,0.03477632,0.01569125,0.010770309,-0.058992233,0.029710522,0.05750853,-0.015117814,-0.06101743,0.037573103,0.080113515,-0.06747062,0.108468354,-0.01645525,-0.039111044,0.0076207076,-0.020311376,0.03250372,-0.056394376,0.06586934,0.056415446,0.035986986,-0.024194224,-0.04767077,-0.04561559,0.008151519,-0.0062884083,0.003754584,0.042429566,-0.05674305,0.02280768,-0.14739722,2.0093278e-33,-0.03134062,0.009305601,-0.012202622,-0.016736928,-0.003696992,0.014587251,-0.0085312985,0.045883376,-0.00771646,0.021908475,-0.04756853,-0.047341246,-0.013579793,0.0047810697,-0.024603523,0.0023957104,0.025201553,-0.00023585433,0.0059854276,0.015610857,0.0037076438,0.025070285,-0.083113804,-0.056952957,0.044493344,0.018563868,-0.0031790088,-0.0070880875,-0.0019934033,-0.018532576,-0.04773848,-0.08935113,-0.06593152,0.044073626,0.042889994,-0.03793057,0.13711676,-0.044318836,-0.045862593,0.0539262,0.02819251,0.007926727,-0.03542398,-0.048935376,0.09064722,-0.085825145,-0.013351207,0.039310165,0.036709886,0.045762602,0.009186083,0.029743768,0.085715175,0.025953038,-0.047524434,0.040616896,-0.07101664,0.017454928,0.009324682,0.04895547,0.015372455,0.04474787,-0.016584394,0.037202027,-0.04214416,-0.013625099,-0.03260131,-0.06421145,-0.020917818,0.12878767,-0.109963834,0.040521614,0.09274827,0.013213125,0.033381443,-0.07790344,-0.12012087,0.08464657,0.0682896,0.04915937,0.029930552,0.05886382,-0.024673885,-0.044251237,-0.08898183,0.014714504,0.044125356,-0.073242694,-0.07180728,0.01764995,0.0405604,-0.052966036,-0.011733051,0.07217775,-0.027495118,-4.325818e-33,0.09640622,-0.0654765,0.0456972,-0.10020906,-0.07671367,0.047633648,0.04520484,-0.027622754,0.010837351,-0.06880921,0.04836058,-0.06066883,0.017551262,-0.065577574,0.021519642,0.0077630393,-0.027818833,0.07775279,-0.03574546,-0.04197071,-0.055937022,0.021166012,-0.013211542,0.007493849,0.098518915,-0.011557668,0.04110456,0.05470562,0.020182101,0.039359022,-0.05103315,0.03708356,0.045467593,-0.019518971,-0.08972744,0.06644093,-0.08692542,-0.009225486,0.06886691,0.016105913,0.016940547,0.02044611,-0.0031614348,0.060993478,-0.029206531,0.08523592,-0.056644425,0.023608355,0.059033703,-0.054502897,0.019271988,-0.0687832,-0.019591076,0.044648003,0.036158197,0.008970902,-0.0030505378,0.039417107,-0.039886676,0.01774123,0.03700243,-0.010003581,0.01589961,0.0029779605,0.05164091,-0.009676523,-0.074939966,0.03793704,0.058400843,-0.020588096,0.037353907,-0.013634833,0.0035633796,0.03621695,-0.02676001,-0.002915312,-0.028841987,-0.0664466,-0.019382412,-0.09548343,-0.04707847,-0.006059587,0.030660845,-0.011875678,0.042294223,-0.031185526,-0.027446706,0.10485785,-0.036826424,0.05052336,-0.06385392,-0.089295745,-0.059823044,0.09314789,0.056023836,-4.860242e-08,0.0008446258,0.0006497414,-0.0029752536,-0.10280129,-0.033915386,0.08305083,0.025091117,-0.046068963,0.015116249,-0.0147056235,-0.023118883,0.013580815,-0.0075141145,0.07733312,-0.009548593,0.025756763,-0.07267317,0.038243845,-0.0010757137,-0.0052318587,-0.089487776,-0.002561163,-0.069568895,-0.022958046,-0.013655488,-0.017367898,0.008077096,0.15127823,-0.005071032,-0.08135234,-0.055011664,0.0073834118,-0.004803973,0.008956381,0.03845848,0.11900288,-0.04986596,-0.03402998,-0.066583164,0.047983978,0.029996097,-0.11220228,-0.048004963,0.013935374,0.051485866,0.023647603,0.025089338,0.06437078,-0.04712734,-0.076651506,0.025283452,-0.029956844,-0.03650546,-0.095279664,-0.11074169,0.0066265594,-0.07083167,-0.06579643,-0.007588796,-0.05917779,0.027405636,-0.03396269,0.15784279,-0.049348243 +3.4.26.2,"The enzyme, isolated from the fungus Scytalidium lignicola and found in several other fungi, has a low pH optimum, being most active at pH 2 with casein as substrate. It differs from the pepsins (EC 3.4.23.1 and EC 3.4.23.2) in being insensitive to inhibition by pepstatin. It also differs from mammalian pepsins in showing a preference for a positively charged residue (Lys or Arg) at the P3 position. In addition to the catalytic Glu residue, a Gln residue appears to play an important role in the hydrolytic mechanism. A member of peptidase family G01, the ""eqolisin"" family of glutamic peptidases (G01.0001).",384,0.99999994,-0.028798,-0.08329928,-0.08364628,-0.03901304,0.12202383,0.08466453,0.0005885238,0.07755418,0.058464892,-0.018244456,0.07269625,-0.0059347814,-0.00436715,0.08635984,-0.055916008,-0.079149336,-0.038398433,-0.07080558,-0.055357903,-0.0746808,0.08010191,-0.018440373,0.021862281,0.049045753,-0.046380587,-0.009664098,0.047649454,-0.04127667,0.026398273,-0.08120281,-0.0012080201,-0.045763317,0.08683476,-0.05344298,0.008725326,0.06543814,-0.058795348,-0.027747981,0.06928774,-0.044654,0.046844427,0.007983969,0.0056220135,-0.06428731,-0.016885467,-0.014088337,0.022405488,0.053400435,0.03355265,-0.02160497,-0.0036023925,-0.08257424,0.011262962,-0.0411205,0.03405437,0.04236379,-0.0035490626,0.0086613055,0.034950215,0.010808922,0.008031213,0.011364171,0.014836818,-0.04858727,-0.04293324,-0.07095675,0.093083136,-0.06866054,0.007270948,0.019682303,-0.009276741,-0.021599675,-0.049757883,-0.01394898,-0.0056162975,0.10479398,0.0017613779,-0.02841006,-0.093374066,0.040647138,0.06963814,-0.029131938,0.02853702,0.060661886,-0.02046258,-0.06478833,-0.013736151,-0.0055980096,0.052285034,-0.026345253,0.1053084,-0.01811476,0.036987122,0.0038708572,-0.040557653,0.04550079,0.03964703,-0.051343177,0.020406488,-0.006449007,0.057409577,0.052743666,0.00018320933,-0.031196898,0.03728527,0.07675987,-0.017051537,0.113506645,0.11679982,-0.0026590133,-0.0012583156,-0.008140898,0.049003646,-0.023740215,-0.06786052,0.026145373,0.064825445,-0.011565895,-0.053331822,-0.0012550267,0.07499707,0.007248154,0.017363355,0.011465079,-0.016762301,0.04119801,-0.107413,2.0137408e-33,0.030411247,-0.02055796,0.003212078,-0.053378895,0.046267964,-0.0016799081,-0.05579926,0.01639102,-0.021911832,-0.077959575,-0.10133382,-0.014061539,-0.057086885,0.031460393,-0.09766589,0.042748544,-0.03903196,-0.08269234,0.024079831,0.07484028,0.0059583243,-0.03930058,-0.093451016,-0.0014452,0.046452682,0.063347615,0.034893207,0.050407074,0.063244075,-0.038828265,0.032150675,-0.05567653,-0.15948902,0.052217618,0.0133045195,0.012146015,0.014234326,-0.02253398,0.060416173,0.008627005,-0.0062810914,0.041959506,0.03295897,-0.040282547,0.07593617,-0.0078079714,-0.0022328864,0.020442063,-0.006723569,0.012660784,0.056434,-0.015019859,0.083707236,0.03441928,-0.070141464,-0.022282485,0.021869972,-0.0167184,0.0073893797,0.04228964,0.05704131,0.075105675,-0.020478511,0.04381909,-0.03552491,0.051959973,-0.08145095,-0.040168975,0.026583321,0.050592303,-0.020063667,0.029560434,0.04242996,0.01860253,-0.007496456,-0.123904675,-0.040549282,0.0030926885,-0.0068464815,0.060084973,-0.023019848,0.026004015,0.045269743,0.060523555,-0.10439737,-0.044541053,-0.024960386,-0.011306382,-0.04821881,-0.03731536,-0.052749444,-0.02359062,-0.035862077,0.07929852,-0.052252818,-3.0700494e-33,0.12737249,-0.073661864,0.10899028,-0.0065980805,-0.06969272,0.05816347,0.040180337,-0.0073746033,0.016657166,-0.059264313,0.027713949,-0.005269925,-0.0030627293,0.0077284453,0.074122414,0.0748687,-0.059815954,0.049373668,-0.032285225,-0.003010595,-0.053124756,0.04809092,-0.042107698,0.045349896,0.09311991,-0.025025953,0.030070875,-0.005008432,-0.026789717,0.025325324,-0.05218294,-0.001419981,-0.05608017,-0.06146542,-0.04681908,-0.025643162,-0.0737324,-0.037010748,-0.014989733,0.032597557,0.04158247,0.04296254,0.06847575,0.07205726,0.032986443,0.102380015,-0.038236137,0.0027129867,-0.020004857,-0.009215722,0.01591445,-0.0077551124,-0.008959793,0.06259657,0.08488727,-0.025080107,0.0440799,0.024206275,-0.00834103,-0.021292334,0.007327513,0.003507485,-0.087597,0.0010449805,-0.006876107,0.030636756,-0.033458218,0.04543971,0.11873284,-0.066133864,0.076621704,-0.054989252,0.097451545,0.041683465,-0.02884043,0.08907726,-0.09729465,-0.029624173,-0.029954746,-0.043041166,0.040159065,0.0010980965,0.002324656,-0.04270231,-0.009313852,-0.075350136,0.032498952,0.06519298,-0.028698852,0.059699778,0.0079096835,-0.02068744,0.025512626,0.05725407,0.05544362,-4.5127695e-08,0.0132729905,-0.026402859,-0.009177693,-0.08170811,-0.080078095,0.0029033045,0.044331815,-0.024260176,0.0072755944,-0.017723234,-0.061797597,-0.020945607,-0.048104677,0.07712859,-0.014907306,0.075274125,-0.052359525,0.046257183,-0.014726437,0.057657763,-0.14429437,0.01711601,-0.1346751,0.010152841,-0.035455216,-0.06819965,0.063945346,0.062898144,-0.020218013,-0.031234015,-0.0502707,0.026327427,-0.018551707,-0.0025594055,-0.013132789,0.025530286,-0.04867216,-0.06198181,-0.022802565,-0.009288484,0.01021469,-0.091341384,-0.05984231,-0.084201574,-0.026207237,-0.058080748,0.011850492,0.043543898,0.036366977,0.06535423,0.047791675,0.0031064216,-0.05122703,-0.028086497,-0.06409831,0.0057463287,0.023122923,-0.056245025,-0.032986626,-0.088122346,0.10338601,0.012714138,0.112155445,0.0065940777 +3.8.2.2,Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase.,384,1.0,-0.020005975,-0.088541955,-0.00126479,-0.03603112,0.019692283,0.05086099,0.10601259,-0.04291958,0.04332131,0.0822538,0.009524659,0.029882295,-0.08477777,0.073089145,-0.05958907,0.02301068,-0.0066925874,-0.020029096,-0.002192973,0.016050216,0.080361694,0.03512433,0.05981268,-0.056714613,-0.0032092223,0.024953114,0.043250572,0.01836008,0.004899491,-0.020439966,0.0010921729,-0.044659533,0.015030937,-0.046898823,0.11386565,0.09536065,-0.11023591,-0.021497322,-0.08709069,0.041535363,0.052628763,-0.10043116,-0.0029591427,0.011573375,-0.024031168,-0.0056050406,-0.036209345,-0.024518678,-0.008222573,-0.08263403,-0.0123924725,-0.012232135,-0.020910924,0.015132442,-0.041941676,0.004256744,-0.059107438,0.09703212,-0.10652009,-0.079062864,0.020342272,0.028106712,0.015443717,-0.015631866,0.001182429,0.052875273,0.1014825,-0.05669394,0.0015731825,-0.0024787905,-0.024719022,-0.08346512,0.0061186417,-0.04430311,0.02603812,0.06106349,-0.03720728,-0.068986915,-0.030001756,-0.081143275,0.035072945,-0.033492845,-0.039875064,0.07170864,0.053000946,0.027208861,-0.046922926,0.0044957586,-0.03821929,-0.004715297,0.010092054,-0.013691921,0.04087916,-0.042385444,-0.07379137,0.032447375,-0.028240083,-0.045232505,0.0031292606,-0.009865373,0.01830235,0.0937834,-0.16293761,-0.022043113,-0.034175515,0.06833879,-0.02330474,-0.030895438,-0.003577343,0.025882589,-0.07322236,-0.021689683,0.010412459,-0.027567305,0.010573467,0.06270174,0.040395677,0.028517483,-0.027991565,-0.0027928792,0.004622386,-0.048088778,-0.065715194,0.07838981,-0.035208516,0.030692397,-0.12490246,2.3158067e-33,0.10654155,0.022275593,0.008172764,-0.059000462,-0.036571786,0.009010395,-0.03638605,-0.03372753,-0.060672708,-0.004306364,-0.040190026,-0.057852406,0.12301023,-0.06388943,-0.020820215,0.013008444,-0.020810002,0.0648863,0.13250434,-0.04883814,0.01587018,0.026733356,-0.026249066,0.075635724,-0.019886876,-0.014221632,-0.04822278,0.051299226,0.05751015,-0.012257366,0.023103375,-0.044306807,-0.10201871,-0.0005644031,-0.0091302,-0.034801964,-0.0854539,-0.018118104,-0.036832478,-0.025648598,-0.077151984,0.005068783,-0.0027461539,-0.007969923,0.022971839,-0.030880634,-0.09174797,0.06282393,0.08860935,-0.034447376,0.06357675,-0.051889908,0.07292918,0.034219764,-0.059401933,0.021406973,0.008403357,-0.04775644,0.0032954258,0.009729885,0.02537559,-0.01636953,-0.008257723,-0.045620263,0.0034518724,0.047831442,-0.034611758,-0.07810355,-0.025882553,0.012036784,-0.06532016,-0.025409307,0.01201157,0.088095196,-0.019871294,0.01848222,-0.027931625,-0.0052421903,-0.032050643,0.10713594,0.02473691,-0.09940047,0.0810904,0.038186688,-0.02705766,-0.05170041,0.033327654,-0.07168577,0.0931706,-0.013208647,0.077855945,-0.10530381,-0.024109984,-0.039826564,-0.011961065,-3.3192357e-33,0.07765141,0.029689187,-0.03464864,-0.029412828,-0.017318388,0.040201776,-0.0028500513,-0.058202967,0.04232054,-0.03755638,0.061901815,-0.02362933,0.04372482,-0.09630328,0.024363695,0.019891005,0.021500332,0.06003214,0.09800728,0.04990806,-0.03432881,0.012543386,0.028621353,0.096235074,-0.029192593,-0.0016825397,-0.004772758,-0.022319196,-0.027504055,0.030198526,0.031031204,0.047982294,-0.084185034,-0.085769944,-0.011413873,0.012805987,-0.032433257,-0.06696328,-0.026338544,0.0398599,0.059192076,0.012658576,0.1582837,0.061902717,0.051214565,0.013318901,-0.03539855,0.017960846,-0.10688432,-0.05249806,-0.00626919,0.11201689,-0.004419884,-0.010252981,0.12755662,0.076417394,-0.0009951406,-0.02339523,0.06985192,-0.010157751,0.03920785,-0.029506378,-0.0033042715,0.014207822,0.016449636,0.057869997,0.008346295,0.011897877,0.062005974,-0.010269678,0.020413645,0.025654474,0.09297356,0.06333415,-0.04264347,-0.02044101,0.0076802727,0.010329934,0.05129767,-0.018690882,0.009290911,0.06537181,-0.027503587,-0.059159,-0.029245,-0.021721257,0.023549719,0.0848244,-0.040907808,-0.06129411,-0.008947159,0.0028180345,0.048499264,0.078203574,0.064922795,-3.6566163e-08,0.091348976,-0.021284185,0.0065964134,-0.044339653,-0.0120681375,-0.041628487,0.13539322,0.069290414,0.008784143,-0.039928157,0.0059006643,-0.0044580763,0.11762828,-0.0070763133,0.0948628,0.048645344,-0.022134783,0.027519412,-0.063298166,-0.05421242,-0.003694557,-0.008156779,-0.11681773,-0.010965764,-0.0048394212,0.008693455,0.063664965,-0.03838351,-0.012364287,0.0145010855,0.0033599737,-0.0073991874,0.021444919,-0.017129619,0.037905473,0.06505264,0.009406681,-0.0320702,-0.026455633,-0.017116347,-0.08866286,-0.018533697,-0.04428111,0.028724667,0.056200128,0.06442427,-0.033322617,0.07802245,-0.025117116,0.014489868,0.014376177,-0.018406287,-0.05267732,-0.06730243,-0.09372982,-0.014693302,0.037580274,-0.02784737,0.03246109,-0.082211636,-0.008690065,-0.006916007,0.031096743,-0.051308658 +4.1.1.124,"This family of enzymes participates in a process that introduces a methyl branch into nascent polyketide products. The process begins with EC 4.1.1.124, malonyl-[acp] decarboxylase, which converts the common extender unit malonyl-[acp] to acetyl-[acp]. The enzyme is a mutated form of a ketosynthase enzyme, in which a Cys residue in the active site is modified to a Ser residue, leaving the decarboxylase function intact, but nulifying the ability of the enzyme to form a carbon-carbon bond. Next, EC 2.3.3.22, 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase, utilizes the acetyl group to introduce the branch at the beta position of 3-oxoacyl intermediates attached to a polyketide synthase, forming a 3-hydroxy-3-carboxymethyl intermediate. This is followed by dehydration catalysed by EC 4.2.1.181, 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase (often referred to as an ECH1 domain), leaving a 3-carboxymethyl group and forming a double bond between the alpha and beta carbons. The process concludes with decarboxylation catalysed by EC 4.1.1.125, 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase (often referred to as an ECH2 domain), leaving a methyl branch at the beta carbon. The enzymes are usually encoded by a cluster of genes referred to as an ""HMGS cassette"", based on the similarity of the key enzyme to EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase. cf. EC 4.1.1.87, malonyl-[malonate decarboxylase] decarboxylase.",384,1.0,-0.03920527,-0.027470605,-0.028627785,-0.019012328,0.06337326,0.014798754,-0.08492947,0.016096057,0.065225445,-0.056271214,0.029221326,-0.03783374,-0.08384552,-0.014638841,-0.045479584,0.050471734,-0.08916954,0.022297446,-0.023949318,-0.0061028404,0.065890536,-0.02076146,-0.034883264,-0.011418971,0.010489323,-0.011095016,0.053043857,-0.0594628,-0.041020416,-0.12211793,0.03527288,-0.014883648,0.004250204,0.006349461,0.059258137,0.10987663,-0.044002768,-0.059376985,0.03562137,0.009037902,0.074071325,-0.014471459,-0.010785542,-0.0009625154,0.001555865,-0.032771036,-0.10104782,-0.017401034,-0.014021093,-0.06181954,-0.00040227905,-0.011683567,-0.0060722213,0.035240855,-0.057351165,-0.0062943976,-0.05141007,0.02266927,-0.023971038,0.015426957,0.059508976,0.03703666,-0.0031120135,-0.04032504,0.0022608812,-0.019528568,0.061290797,-0.07119275,0.017477993,0.03560575,-0.13331503,-0.05912809,-0.034689117,0.038129054,0.040254004,-0.0073322887,-0.00247528,-0.03368475,0.07563911,0.010603264,-0.014433816,0.04079989,0.0619417,0.006978748,0.031495195,-0.00879104,0.02001721,0.009913665,-0.0068330886,0.049398094,-0.012512244,-0.05075881,-0.026455913,0.01856174,0.03131751,0.04218272,0.045910668,0.020631952,0.03277239,-0.0037290906,0.0014147261,0.08360556,-0.020552529,-0.15069765,-0.017728642,0.043888412,0.0016999774,0.060848635,0.06857037,0.024274345,-0.06953378,-0.017142318,-0.028202528,-0.034382433,-0.02534875,0.15678874,-0.031325657,-0.06501105,0.06616346,-0.026528493,0.06730714,-0.035664544,0.027458357,0.05415659,-0.02035535,0.03418927,-0.17307997,1.2787828e-33,0.019414041,0.029050801,0.03691077,-0.014210305,0.0133706,-0.03461659,-0.08762255,0.052123718,-0.09085645,-0.011221338,-0.06406871,-0.06542413,0.07375239,-0.014044614,-0.033679985,-0.09632226,-0.065621026,-0.0039871386,0.019741056,-0.03280212,-0.0232447,0.07085806,-0.070814565,0.071901895,-0.007605459,0.01400635,-0.010147713,0.0262667,0.042919725,0.009239714,-0.00480383,-0.0058504785,-0.06475805,0.04328582,0.0077339346,0.057709824,-0.004937431,-0.05387747,0.042129956,0.07513287,0.10842434,0.011890589,0.061389707,-0.08089018,0.024079632,-0.027485209,-0.06138205,0.054534543,0.034153346,0.030515622,0.03399658,0.024497041,0.025556237,0.012392221,-0.03983523,0.011721815,-0.12436275,-0.008674815,0.018139152,0.016975507,-0.016820785,0.00028441125,-0.03102894,0.01943851,-0.054184824,0.05845465,-0.043934617,-0.012532321,-0.0036996794,0.03340269,-0.075225145,0.019040737,0.082392775,0.043651775,0.046603605,-0.016574023,-0.070647314,0.034505446,0.04492699,0.04096281,-0.06834034,0.031841524,0.004334857,-0.040429253,-0.03389106,-0.053852115,-0.02313863,0.046848044,0.03110108,0.0641849,0.034797907,-0.071629025,0.034817453,0.08811088,-0.011535745,-3.1707256e-33,0.112932295,-0.10138224,0.0141667845,-0.071814284,-0.025901247,0.028358595,0.07655783,-0.07458951,0.007844475,-0.026284413,0.09166308,0.02392737,0.08339449,-0.018747559,0.030659882,0.026851803,-0.057176035,0.03694117,0.006751466,0.041083112,0.07539934,0.08027225,-0.011484566,0.077288866,0.044252224,0.014930714,-0.03768142,0.055715162,0.09817982,0.021426711,-0.041388612,-0.014125734,-0.009756567,0.0040709684,-0.061311103,0.036123835,-0.07499368,-0.0156040145,-0.01567264,0.043065626,-0.0074841273,-0.009419204,-0.045671128,0.058649607,0.10265818,0.10770498,-0.029764678,-0.0025559827,0.02479328,-0.0890008,-0.0021378582,0.028181948,0.009275655,0.050756924,-0.017231204,0.1295808,0.008836373,0.0074991537,0.0044556893,-0.0018925214,-0.04438439,-0.017156864,0.07358105,-0.06101827,0.036775045,0.015070403,-0.054983072,0.035722118,0.033508457,-0.027903017,0.028354837,0.03725642,-0.031444896,0.021268712,0.028385075,-0.0963424,-0.06104268,-0.051739,-0.06856363,-0.10883963,-0.05466531,0.011713593,0.0114337485,-0.044252727,-0.033152673,-0.05661744,0.056295566,0.10080575,-0.0458918,0.021371024,-0.05237584,0.026774712,-0.07811305,0.13148768,0.07474051,-4.981113e-08,0.0043672794,0.023466187,0.015458882,-0.05227752,0.02801486,0.06166408,0.004159366,0.04296049,-0.010236914,-0.09548676,-0.05405903,0.07013667,0.019651996,0.044489108,0.011199816,-0.039980873,-0.043459233,0.038749468,0.022933884,-0.036414083,-0.100433365,0.015165111,-0.05425967,0.013498479,-0.044322748,-0.0079739485,0.03958477,0.11207614,-0.0398914,0.0066452892,-0.041173678,0.1359673,0.032473776,-0.0012238879,-0.06359138,-0.0021994023,-0.06384543,-0.049338043,-0.030067988,0.08371411,0.06968616,-0.03398554,-0.0532775,0.008045306,0.034475792,-0.038358368,0.014618655,-0.046119627,0.0023584801,-0.02166452,0.070959695,0.0072043706,-0.061957363,-0.015027123,0.010520868,0.04217341,-0.08857494,-0.0886098,5.0202576e-05,-0.04644533,-0.028589241,-0.044450644,0.12543914,-0.035399776 +4.1.1.125,"This family of enzymes participates in a process that introduces a methyl branch into nascent polyketide products. The process begins with EC 4.1.1.124, malonyl-[acp] decarboxylase, which converts the common extender unit malonyl-[acp] to acetyl-[acp]. The enzyme is a mutated form of a ketosynthase enzyme, in which a Cys residue in the active site is modified to a Ser residue, leaving the decarboxylase function intact, but nulifying the ability of the enzyme to form a carbon-carbon bond. Next, EC 2.3.3.22, 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase, utilizes the acetyl group to introduce the branch at the beta position of 3-oxoacyl intermediates attached to a polyketide synthase, forming a 3-hydroxy-3-carboxymethyl intermediate. This is followed by dehydration catalysed by EC 4.2.1.181, 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase (often referred to as an ECH1 domain), leaving a 3-carboxymethyl group and forming a double bond between the alpha and beta carbons. The process concludes with decarboxylation catalysed by EC 4.1.1.125, 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase (often referred to as an ECH2 domain), leaving a methyl branch at the beta carbon. The enzymes are usually encoded by a cluster of genes referred to as an ""HMGS cassette"", based on the similarity of the key enzyme to EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase.",384,1.0,-0.03920527,-0.027470605,-0.028627785,-0.019012328,0.06337326,0.014798754,-0.08492947,0.016096057,0.065225445,-0.056271214,0.029221326,-0.03783374,-0.08384552,-0.014638841,-0.045479584,0.050471734,-0.08916954,0.022297446,-0.023949318,-0.0061028404,0.065890536,-0.02076146,-0.034883264,-0.011418971,0.010489323,-0.011095016,0.053043857,-0.0594628,-0.041020416,-0.12211793,0.03527288,-0.014883648,0.004250204,0.006349461,0.059258137,0.10987663,-0.044002768,-0.059376985,0.03562137,0.009037902,0.074071325,-0.014471459,-0.010785542,-0.0009625154,0.001555865,-0.032771036,-0.10104782,-0.017401034,-0.014021093,-0.06181954,-0.00040227905,-0.011683567,-0.0060722213,0.035240855,-0.057351165,-0.0062943976,-0.05141007,0.02266927,-0.023971038,0.015426957,0.059508976,0.03703666,-0.0031120135,-0.04032504,0.0022608812,-0.019528568,0.061290797,-0.07119275,0.017477993,0.03560575,-0.13331503,-0.05912809,-0.034689117,0.038129054,0.040254004,-0.0073322887,-0.00247528,-0.03368475,0.07563911,0.010603264,-0.014433816,0.04079989,0.0619417,0.006978748,0.031495195,-0.00879104,0.02001721,0.009913665,-0.0068330886,0.049398094,-0.012512244,-0.05075881,-0.026455913,0.01856174,0.03131751,0.04218272,0.045910668,0.020631952,0.03277239,-0.0037290906,0.0014147261,0.08360556,-0.020552529,-0.15069765,-0.017728642,0.043888412,0.0016999774,0.060848635,0.06857037,0.024274345,-0.06953378,-0.017142318,-0.028202528,-0.034382433,-0.02534875,0.15678874,-0.031325657,-0.06501105,0.06616346,-0.026528493,0.06730714,-0.035664544,0.027458357,0.05415659,-0.02035535,0.03418927,-0.17307997,1.2787828e-33,0.019414041,0.029050801,0.03691077,-0.014210305,0.0133706,-0.03461659,-0.08762255,0.052123718,-0.09085645,-0.011221338,-0.06406871,-0.06542413,0.07375239,-0.014044614,-0.033679985,-0.09632226,-0.065621026,-0.0039871386,0.019741056,-0.03280212,-0.0232447,0.07085806,-0.070814565,0.071901895,-0.007605459,0.01400635,-0.010147713,0.0262667,0.042919725,0.009239714,-0.00480383,-0.0058504785,-0.06475805,0.04328582,0.0077339346,0.057709824,-0.004937431,-0.05387747,0.042129956,0.07513287,0.10842434,0.011890589,0.061389707,-0.08089018,0.024079632,-0.027485209,-0.06138205,0.054534543,0.034153346,0.030515622,0.03399658,0.024497041,0.025556237,0.012392221,-0.03983523,0.011721815,-0.12436275,-0.008674815,0.018139152,0.016975507,-0.016820785,0.00028441125,-0.03102894,0.01943851,-0.054184824,0.05845465,-0.043934617,-0.012532321,-0.0036996794,0.03340269,-0.075225145,0.019040737,0.082392775,0.043651775,0.046603605,-0.016574023,-0.070647314,0.034505446,0.04492699,0.04096281,-0.06834034,0.031841524,0.004334857,-0.040429253,-0.03389106,-0.053852115,-0.02313863,0.046848044,0.03110108,0.0641849,0.034797907,-0.071629025,0.034817453,0.08811088,-0.011535745,-3.1707256e-33,0.112932295,-0.10138224,0.0141667845,-0.071814284,-0.025901247,0.028358595,0.07655783,-0.07458951,0.007844475,-0.026284413,0.09166308,0.02392737,0.08339449,-0.018747559,0.030659882,0.026851803,-0.057176035,0.03694117,0.006751466,0.041083112,0.07539934,0.08027225,-0.011484566,0.077288866,0.044252224,0.014930714,-0.03768142,0.055715162,0.09817982,0.021426711,-0.041388612,-0.014125734,-0.009756567,0.0040709684,-0.061311103,0.036123835,-0.07499368,-0.0156040145,-0.01567264,0.043065626,-0.0074841273,-0.009419204,-0.045671128,0.058649607,0.10265818,0.10770498,-0.029764678,-0.0025559827,0.02479328,-0.0890008,-0.0021378582,0.028181948,0.009275655,0.050756924,-0.017231204,0.1295808,0.008836373,0.0074991537,0.0044556893,-0.0018925214,-0.04438439,-0.017156864,0.07358105,-0.06101827,0.036775045,0.015070403,-0.054983072,0.035722118,0.033508457,-0.027903017,0.028354837,0.03725642,-0.031444896,0.021268712,0.028385075,-0.0963424,-0.06104268,-0.051739,-0.06856363,-0.10883963,-0.05466531,0.011713593,0.0114337485,-0.044252727,-0.033152673,-0.05661744,0.056295566,0.10080575,-0.0458918,0.021371024,-0.05237584,0.026774712,-0.07811305,0.13148768,0.07474051,-4.981113e-08,0.0043672794,0.023466187,0.015458882,-0.05227752,0.02801486,0.06166408,0.004159366,0.04296049,-0.010236914,-0.09548676,-0.05405903,0.07013667,0.019651996,0.044489108,0.011199816,-0.039980873,-0.043459233,0.038749468,0.022933884,-0.036414083,-0.100433365,0.015165111,-0.05425967,0.013498479,-0.044322748,-0.0079739485,0.03958477,0.11207614,-0.0398914,0.0066452892,-0.041173678,0.1359673,0.032473776,-0.0012238879,-0.06359138,-0.0021994023,-0.06384543,-0.049338043,-0.030067988,0.08371411,0.06968616,-0.03398554,-0.0532775,0.008045306,0.034475792,-0.038358368,0.014618655,-0.046119627,0.0023584801,-0.02166452,0.070959695,0.0072043706,-0.061957363,-0.015027123,0.010520868,0.04217341,-0.08857494,-0.0886098,5.0202576e-05,-0.04644533,-0.028589241,-0.044450644,0.12543914,-0.035399776 +4.1.1.126,"The enzyme catalyses a step in the archaeal prenyl diphosphate biosynthesis pathway. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.",384,1.0,-0.07901706,-0.03867521,-0.06419259,-0.0120257605,0.09647283,0.04129557,-0.077643625,-0.000546262,0.061525002,0.0062516932,0.007505217,-0.087439984,-0.09995063,-0.006189018,-0.03172566,0.0010789682,-0.117431894,0.0060178745,0.0022406022,-0.04605834,0.08182904,0.044832535,0.0141200125,0.014094499,-0.022230249,0.015048559,0.050661325,-0.044858746,0.055630118,-0.04925073,0.03346977,-0.030099606,0.0681471,-0.07125228,0.040595707,0.14863701,0.012181339,-0.119524896,0.0680624,0.015097188,0.056666553,-0.030723795,0.089961156,-0.022182642,-0.043984406,0.01442543,0.07225273,0.05010096,0.021734932,0.013637643,-0.07101652,-0.01781094,-0.06556669,-0.05000735,0.048911184,0.078886226,-0.041167393,-0.06708039,0.0022540374,-0.06897035,0.031060496,-0.01103572,-0.046821687,-0.006772957,0.013894138,-0.014516385,0.039613098,-0.053752515,0.08178063,0.026737953,-0.07772928,-0.0001883759,-0.022469422,0.032970697,-0.02761559,0.071488425,0.021894231,0.016220406,0.032479122,-0.06105218,0.05003774,-0.026467133,-0.004077533,0.035694942,0.032705493,-0.045855515,-0.005785968,0.019377967,0.08927178,0.047392868,0.028609414,-0.039903447,0.07462452,-0.060783118,-0.07957547,0.08959961,0.028219145,0.01115448,0.024279783,-0.004034582,-0.00046956047,0.04300975,0.007556065,0.0032883834,-0.029206056,-0.047542278,-0.008459626,0.15603817,0.013936494,0.044072773,0.049032915,-0.048977397,0.09000577,-0.007816539,-0.053914227,0.12132078,-0.04705926,-0.10403603,-0.066485055,0.02676555,-0.011032965,-0.011049536,0.05007623,0.11120813,-0.062455546,0.0029704175,-0.16942948,4.234713e-33,0.10487656,0.010186133,0.048868723,-0.035445824,-0.04670655,-0.007946689,-0.069847636,-0.00374042,-0.020285137,-0.009707365,-0.026275879,-0.06847035,0.05295104,-0.026143441,-0.07097914,-0.07491425,-0.034046892,-0.038417075,0.037834406,0.016015446,-0.04571592,0.015440655,-0.03597661,0.013381267,0.03592309,0.049550273,-0.03696327,-0.019159451,0.020559153,0.022963272,0.024599042,-0.13877174,-0.054801922,-0.022653863,0.0741625,-0.062075224,-0.014431003,-0.08075625,-0.050266705,0.01654044,-0.022659114,0.01640244,-0.016904783,-0.037350766,0.050021045,-0.051116478,-0.025289215,0.105188794,0.062831,0.07044728,0.038248014,-0.007106929,0.10731848,0.010909383,-0.09056953,0.021317558,-0.037121363,-0.034625925,0.03778808,0.045068808,0.005589588,0.045115616,-0.022925816,0.060968395,0.012841363,0.03041789,0.028595528,-0.05430505,0.06500805,0.096775405,-0.033200394,-0.039869506,0.017358257,0.04001521,0.04525479,0.006899322,-0.037297502,-0.05093869,-0.009609592,0.016778078,-0.03336666,-0.0036866798,0.012209795,-0.009403502,-0.0044125845,0.03606121,-0.05620978,-0.036505647,-0.010695641,0.04690285,0.0251238,-0.08153709,0.0018278931,0.013611677,-0.013786321,-3.604473e-33,0.07923715,-0.097936675,-0.034621134,-0.09549786,-0.09360142,0.05076958,0.03888587,-0.06729213,0.014718057,0.009120161,0.02839497,-0.0074422723,0.055273384,-0.06790498,0.057307743,0.011453043,0.017041543,0.041664917,0.07305961,0.04481384,0.045743946,0.023122786,-0.007136661,0.07466624,0.00047657057,0.017911658,0.045095034,0.06453799,-0.01846194,0.08744732,-0.07542655,0.011646785,-0.033210285,-0.034364536,-0.09042289,-0.01348276,-0.029747536,0.030249208,0.0061106663,-0.014197907,0.046132647,0.057666063,-0.013356146,0.0049187066,-0.009733332,0.038555596,-0.048365563,0.063527636,-0.02165449,-0.04657898,-0.04905071,0.010432358,0.0051861983,-7.159013e-05,0.0010288613,0.010022594,0.012928001,0.04640671,0.06090344,-0.012699598,-0.04735249,-0.10256972,0.05317923,-0.05534806,0.114528164,0.058526784,-0.0071043153,0.109219305,-0.006706688,-0.019624956,0.031107845,-0.017333278,0.044613667,0.042847414,0.023106914,0.022962572,-0.013677168,-0.052777,0.061867837,-0.07040172,-0.0022155035,0.027153065,0.033567887,-0.10810699,-0.030515632,-0.03738304,0.060467526,0.05247318,0.013984698,0.07640272,-0.042254794,-0.0072396854,0.026150715,-0.014053,0.028678859,-3.326315e-08,-0.024200102,-0.004148513,0.074735306,0.033125825,0.036924973,0.115022466,0.03451465,0.022858787,-0.0023568145,-0.02572884,-0.018350048,0.024642227,0.07691262,-0.0035583198,0.022723906,0.019130193,-0.057569094,0.038318098,-0.089544505,-0.054723464,-0.03316305,0.010232153,-0.03808482,0.00995106,0.014033251,-0.0642085,0.015220984,0.028370043,0.0051155514,-0.023278726,-0.035968695,0.0016548487,-0.009045473,-0.041835092,-0.120000415,0.005897663,-0.021845806,-0.0498828,-0.037958,0.012807197,-0.08306848,0.03080967,-0.06070686,-0.0054976502,-0.045447405,0.056589644,0.010631786,0.06362012,-0.007766491,0.025086092,0.038271956,-0.02856462,-0.00026844503,-0.052488554,-0.07582504,-0.08998695,-0.0151743535,-0.0282502,-0.033771724,-0.0013742996,0.066306934,0.041076202,0.1624985,-0.06065764 +4.2.1.181,"This family of enzymes participates in a process that introduces a methyl branch into nascent polyketide products. The process begins with EC 4.1.1.124, malonyl-[acp] decarboxylase, which converts the common extender unit malonyl-[acp] to acetyl-[acp]. The enzyme is a mutated form of a ketosynthase enzyme, in which a Cys residue in the active site is modified to a Ser residue, leaving the decarboxylase function intact, but nulifying the ability of the enzyme to form a carbon-carbon bond. Next, EC 2.3.3.22, 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase, utilizes the acetyl group to introduce the branch at the beta position of 3-oxoacyl intermediates attached to a polyketide synthase, forming a 3-hydroxy-3-carboxymethyl intermediate. This is followed by dehydration catalysed by EC 4.2.1.181, 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase (often referred to as an ECH1 domain), leaving a 3-carboxymethyl group and forming a double bond between the alpha and beta carbons. The process concludes with decarboxylation catalysed by EC 4.1.1.125, 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase (often referred to as an ECH2 domain), leaving a methyl branch at the beta carbon. The enzymes are usually encoded by a cluster of genes referred to as an ""HMGS cassette"", based on the similarity of the key enzyme to EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase. cf. EC 4.2.1.18, methylglutaconyl-CoA hydratase.",384,1.0,-0.03920527,-0.027470605,-0.028627785,-0.019012328,0.06337326,0.014798754,-0.08492947,0.016096057,0.065225445,-0.056271214,0.029221326,-0.03783374,-0.08384552,-0.014638841,-0.045479584,0.050471734,-0.08916954,0.022297446,-0.023949318,-0.0061028404,0.065890536,-0.02076146,-0.034883264,-0.011418971,0.010489323,-0.011095016,0.053043857,-0.0594628,-0.041020416,-0.12211793,0.03527288,-0.014883648,0.004250204,0.006349461,0.059258137,0.10987663,-0.044002768,-0.059376985,0.03562137,0.009037902,0.074071325,-0.014471459,-0.010785542,-0.0009625154,0.001555865,-0.032771036,-0.10104782,-0.017401034,-0.014021093,-0.06181954,-0.00040227905,-0.011683567,-0.0060722213,0.035240855,-0.057351165,-0.0062943976,-0.05141007,0.02266927,-0.023971038,0.015426957,0.059508976,0.03703666,-0.0031120135,-0.04032504,0.0022608812,-0.019528568,0.061290797,-0.07119275,0.017477993,0.03560575,-0.13331503,-0.05912809,-0.034689117,0.038129054,0.040254004,-0.0073322887,-0.00247528,-0.03368475,0.07563911,0.010603264,-0.014433816,0.04079989,0.0619417,0.006978748,0.031495195,-0.00879104,0.02001721,0.009913665,-0.0068330886,0.049398094,-0.012512244,-0.05075881,-0.026455913,0.01856174,0.03131751,0.04218272,0.045910668,0.020631952,0.03277239,-0.0037290906,0.0014147261,0.08360556,-0.020552529,-0.15069765,-0.017728642,0.043888412,0.0016999774,0.060848635,0.06857037,0.024274345,-0.06953378,-0.017142318,-0.028202528,-0.034382433,-0.02534875,0.15678874,-0.031325657,-0.06501105,0.06616346,-0.026528493,0.06730714,-0.035664544,0.027458357,0.05415659,-0.02035535,0.03418927,-0.17307997,1.2787828e-33,0.019414041,0.029050801,0.03691077,-0.014210305,0.0133706,-0.03461659,-0.08762255,0.052123718,-0.09085645,-0.011221338,-0.06406871,-0.06542413,0.07375239,-0.014044614,-0.033679985,-0.09632226,-0.065621026,-0.0039871386,0.019741056,-0.03280212,-0.0232447,0.07085806,-0.070814565,0.071901895,-0.007605459,0.01400635,-0.010147713,0.0262667,0.042919725,0.009239714,-0.00480383,-0.0058504785,-0.06475805,0.04328582,0.0077339346,0.057709824,-0.004937431,-0.05387747,0.042129956,0.07513287,0.10842434,0.011890589,0.061389707,-0.08089018,0.024079632,-0.027485209,-0.06138205,0.054534543,0.034153346,0.030515622,0.03399658,0.024497041,0.025556237,0.012392221,-0.03983523,0.011721815,-0.12436275,-0.008674815,0.018139152,0.016975507,-0.016820785,0.00028441125,-0.03102894,0.01943851,-0.054184824,0.05845465,-0.043934617,-0.012532321,-0.0036996794,0.03340269,-0.075225145,0.019040737,0.082392775,0.043651775,0.046603605,-0.016574023,-0.070647314,0.034505446,0.04492699,0.04096281,-0.06834034,0.031841524,0.004334857,-0.040429253,-0.03389106,-0.053852115,-0.02313863,0.046848044,0.03110108,0.0641849,0.034797907,-0.071629025,0.034817453,0.08811088,-0.011535745,-3.1707256e-33,0.112932295,-0.10138224,0.0141667845,-0.071814284,-0.025901247,0.028358595,0.07655783,-0.07458951,0.007844475,-0.026284413,0.09166308,0.02392737,0.08339449,-0.018747559,0.030659882,0.026851803,-0.057176035,0.03694117,0.006751466,0.041083112,0.07539934,0.08027225,-0.011484566,0.077288866,0.044252224,0.014930714,-0.03768142,0.055715162,0.09817982,0.021426711,-0.041388612,-0.014125734,-0.009756567,0.0040709684,-0.061311103,0.036123835,-0.07499368,-0.0156040145,-0.01567264,0.043065626,-0.0074841273,-0.009419204,-0.045671128,0.058649607,0.10265818,0.10770498,-0.029764678,-0.0025559827,0.02479328,-0.0890008,-0.0021378582,0.028181948,0.009275655,0.050756924,-0.017231204,0.1295808,0.008836373,0.0074991537,0.0044556893,-0.0018925214,-0.04438439,-0.017156864,0.07358105,-0.06101827,0.036775045,0.015070403,-0.054983072,0.035722118,0.033508457,-0.027903017,0.028354837,0.03725642,-0.031444896,0.021268712,0.028385075,-0.0963424,-0.06104268,-0.051739,-0.06856363,-0.10883963,-0.05466531,0.011713593,0.0114337485,-0.044252727,-0.033152673,-0.05661744,0.056295566,0.10080575,-0.0458918,0.021371024,-0.05237584,0.026774712,-0.07811305,0.13148768,0.07474051,-4.981113e-08,0.0043672794,0.023466187,0.015458882,-0.05227752,0.02801486,0.06166408,0.004159366,0.04296049,-0.010236914,-0.09548676,-0.05405903,0.07013667,0.019651996,0.044489108,0.011199816,-0.039980873,-0.043459233,0.038749468,0.022933884,-0.036414083,-0.100433365,0.015165111,-0.05425967,0.013498479,-0.044322748,-0.0079739485,0.03958477,0.11207614,-0.0398914,0.0066452892,-0.041173678,0.1359673,0.032473776,-0.0012238879,-0.06359138,-0.0021994023,-0.06384543,-0.049338043,-0.030067988,0.08371411,0.06968616,-0.03398554,-0.0532775,0.008045306,0.034475792,-0.038358368,0.014618655,-0.046119627,0.0023584801,-0.02166452,0.070959695,0.0072043706,-0.061957363,-0.015027123,0.010520868,0.04217341,-0.08857494,-0.0886098,5.0202576e-05,-0.04644533,-0.028589241,-0.044450644,0.12543914,-0.035399776 +4.2.1.182,"The enzyme catalyses a step in an archaeal prenyl diphosphate biosynthesis pathway. It belongs to the aconitase X family, and contains a [4Fe-4S] cluster.",384,1.0,-0.062111456,-0.015870044,-0.061723255,-0.004438733,0.05875278,0.008196514,-0.048743665,-0.004568997,0.030323016,-0.03509066,0.017670734,-0.07816392,-0.010626018,-0.016793506,-0.092266954,0.017819207,-0.074967176,-0.02686658,0.024053996,-0.050745342,0.03854094,0.032831006,-0.021864774,-0.036625788,0.017386923,0.043622,0.07925242,-0.06871985,-0.013703991,-0.048310373,-0.04698267,-0.026529636,0.10582368,-0.05953356,0.058153447,0.17425688,0.020625772,-0.052039217,0.079909876,-0.0031021659,0.04181832,-0.031284846,0.060123336,-0.0050959126,-0.039738875,0.019088661,0.045252748,-0.017656848,0.05420754,-0.0077515724,-0.08718279,0.020600978,-0.05387209,0.017312426,0.058752872,0.02637101,-0.018271198,-0.056808,-0.031696912,-0.0034198042,0.06396662,-0.078379594,-0.02667389,0.010649645,0.04527517,0.000379553,0.039645985,-0.02228167,0.04758808,-0.021195684,-0.03844031,0.019436011,-0.0038323756,0.00020420176,-0.009952839,0.08492348,0.043507427,-0.035771362,0.037948128,-0.06986965,0.0046348576,0.018535804,0.04585917,0.018951898,0.031298775,-0.015198054,0.020350328,-0.04848602,0.07317278,0.03239973,0.00051805226,0.00015031379,0.028635634,-0.102186404,-0.049399544,0.04838105,0.010286512,-0.029650029,0.013208501,-0.008482907,0.015494416,0.106432155,-0.055498645,-0.039067794,-0.034252096,-0.045225892,-0.026812762,0.15923363,-0.020909041,0.06616946,0.0062259,-0.036922563,0.04173352,0.028699744,-0.042626485,0.0562155,0.0026598866,-0.053941157,-0.10386436,0.022085754,-0.016295211,0.024318986,0.004474347,0.101015195,-0.02261809,-0.0023476353,-0.17730077,4.5942727e-34,0.06699203,0.07360736,0.04034048,-0.061522085,0.017663533,-0.014299219,-0.08882008,0.0013322181,-0.029163083,0.029025722,-0.022099327,-0.097690836,0.071014136,-0.06522164,-0.08467676,-0.10460837,-0.032101773,0.020122282,0.047615264,-0.008135547,-0.058522068,0.07146596,-0.021408143,-0.012069445,0.011299346,0.021609543,-0.015996402,-0.03704506,0.015350087,0.020624805,-0.022273768,-0.07570923,-0.12118922,-0.080620475,0.056251764,-0.06360832,0.016682243,-0.08855447,-0.045221772,0.02686094,-0.069652624,0.036902554,-0.003962283,-0.06687897,0.04953488,-0.07603647,-0.038186233,0.07401933,0.036002826,0.10051843,-0.014012172,-0.05014806,0.14917669,0.009456092,-0.10187141,-0.016873933,-0.08392386,-0.013972247,0.040769298,0.058706593,0.06524656,0.02929758,-0.06855085,0.040891025,-0.020794112,0.028074678,0.017553639,-0.03047458,0.04891779,0.16363643,0.011609919,-0.040945068,0.043608688,0.040662803,0.003169534,-0.0042499355,-0.06027435,-0.02579038,-0.009423185,0.0039160247,-0.021185353,-0.04325407,0.039985616,-0.034829732,-0.017261017,0.009131334,-0.013009287,-0.014085764,0.012504934,0.009357063,0.047714528,-0.011532216,-0.03117948,0.022149805,-0.034146182,-8.928806e-34,0.11376795,-0.10034947,0.016053978,-0.13174707,-0.09925857,0.020695366,0.04561389,-0.020422623,-0.006544366,0.022675483,0.07465454,0.0056615896,0.05931313,-0.09666907,0.021800939,0.033570465,0.025152905,0.04383965,0.08025252,0.05706036,0.03726534,0.059293196,0.019939153,0.06701281,0.05010656,0.016124312,0.03587038,0.07644184,-0.0016464004,0.06773193,-0.044330206,-0.002698271,-0.002611648,-0.019962922,-0.059566636,0.0037593415,-0.032327864,0.009454731,0.0396601,0.024496099,0.045728214,0.08194741,0.029110918,0.077920176,0.014890698,0.018698856,-0.029606722,0.1348245,0.0047161733,-0.081306644,-0.013293215,-0.039241843,0.027055595,-0.019298796,0.014013556,0.02799225,-0.025978236,0.032214966,-0.017501771,-0.005416932,-0.02126876,-0.13663453,0.06419373,-0.0062286,0.10508944,0.05061614,-0.03441815,0.044070143,-0.03708671,0.011977738,0.036993522,-0.017563827,0.009621702,0.018648006,0.006634944,0.01376295,-0.001094568,-0.039469972,0.00956783,-0.03264795,-0.062140435,0.06791297,-0.004620991,-0.077404216,-0.055304848,-0.03497149,0.07852029,0.09550078,0.0033911609,0.049181305,-0.064629324,0.014977368,0.053373042,0.023686823,0.042533316,-2.7640482e-08,0.058611378,0.0008237822,0.10145743,0.029678471,0.017320698,0.07437619,-0.0069016013,-0.020018239,0.044742323,-0.010189789,-0.025404662,0.032527354,0.038773764,-0.024377756,0.038786046,0.012458853,-0.05853632,0.028542701,-0.06497685,-0.030906728,-0.023923727,-0.024098797,-0.0726784,0.020869981,0.03970185,-0.05179704,0.036356315,-0.021624861,-0.04018643,-0.0447126,-0.036865942,-0.0032004104,-0.007980387,-0.041879103,-0.061921228,0.051278368,-0.04671205,-0.041138493,-0.016578248,-0.016361477,-0.07646745,-0.024219584,-0.040234637,0.005970712,-0.06981223,0.070737906,0.009990226,0.026724504,-0.011406132,0.022302954,0.0091015985,0.014507278,0.042149395,-0.040147748,-0.039222807,-0.020530604,-0.062151216,-0.032000363,0.022298852,0.0004524794,0.07146311,0.044429854,0.12482118,-0.07201411 +4.2.2.29,"A group of bacterial enzymes that catalyse the non-hydrolytic cleavage of peptidoglycan (PG). The enzymes fragment the polysaccharide chain at the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues by an intramolecular cyclization of the N-acetylmuramyl moiety to yield a 1,6-anhydro-N-acetyl-beta-D-muramyl product. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. The MtlG enzyme of Gram-negative bacteria may function to regulate glycan strand length within the PG polymer.",384,1.0,-0.07893911,-0.066147275,-0.030436177,0.020064471,-0.016951317,0.0077129467,-0.047232933,0.029204393,0.026889065,0.008458746,-0.021824405,0.10632714,0.05432794,0.051467,-0.09210359,0.0060403296,-0.016735863,0.010329349,0.030269926,-0.0010240086,0.09041815,-0.03297003,-0.032945685,0.015451212,0.02009121,-0.020176549,0.019441696,-0.06801037,0.0006265975,-0.0494404,0.00427678,-0.062126856,0.044530984,-0.0058712577,0.060622323,0.10736813,0.02326627,0.01514122,0.043602116,-0.0016497795,0.024487726,0.032415647,-0.0018797421,-0.050491504,0.0357039,-0.08129392,-0.028234188,0.019967575,0.03195922,-0.021253025,-0.042316224,-0.031964395,-0.010579371,-0.018404843,0.057288833,0.036264513,-0.062009037,-0.02501933,0.06896173,0.046053953,-0.0032793214,0.0058608735,-0.010155003,-0.007304506,-0.10302941,-0.11630861,0.050052106,0.0027549737,-0.0060475767,0.083177365,-0.10901623,0.0026367302,-0.04793527,-0.0017395363,0.033384632,0.005272114,-0.036694907,-0.026248345,0.03826512,-0.010005225,0.02213272,-0.018387252,0.10355759,0.0466149,-0.026173625,0.006488111,0.066439785,0.030389078,0.05028244,-0.0077785435,0.023844961,-0.062532224,0.029612578,-0.018298196,-0.025778819,-0.065751284,0.022692883,-0.06873247,0.048632443,-0.007613614,0.015278617,-0.0078124423,0.06602514,-0.09820728,-0.043296956,0.05236071,-0.041214187,0.1042763,0.11274564,0.0063475915,-0.054069847,0.06583367,0.041483097,0.0039943163,-0.04300228,0.035792936,-0.012744506,-0.03631613,-0.0048250915,-0.031559665,0.04498571,-0.0013926734,0.024387555,0.016997611,-0.050840627,0.07733031,0.00019873091,3.8990207e-33,0.0409632,0.01792424,0.061565988,0.016544435,-0.020478353,-0.007483119,-0.04254425,0.0046372125,-0.054466985,0.0032448357,0.011424009,-0.010444207,-0.0035720477,0.12888384,0.010107384,0.09139485,-0.011737057,-0.04752003,0.066687554,-0.019125061,-0.04547213,0.022366218,0.0121372035,-0.06480791,0.114484236,0.026647244,-0.033008676,0.029210854,0.027137585,-0.0037256847,-0.015871348,-0.056420833,-0.06229442,0.06305378,0.052390195,0.018264547,-0.055791233,-0.06256121,0.042515896,0.055248924,0.029152952,0.017560678,-0.0022054298,-0.038344752,0.0029277967,0.076134264,0.04827492,0.06375365,-0.07686504,0.09309026,0.071337596,0.014199916,0.039921794,0.010602515,-0.10236868,0.06624071,-0.008776914,-0.050507765,0.016633807,0.02282863,0.033975676,0.04074403,0.012974979,-0.070094824,-0.021303507,-0.011001894,-0.039424434,0.03798788,0.016090626,0.010933611,-0.06862886,-0.01843426,0.060615256,0.050561,-0.012599656,-0.07589425,-0.032904584,0.0058935373,0.04771641,0.0046186196,-0.049993407,0.020258576,0.017294075,-0.0809209,-0.047004886,0.020635534,0.0052640676,-0.09568681,-0.039099466,0.06053548,-0.06242522,-0.09408496,-0.034044303,0.13443308,-0.05288521,-5.480673e-33,0.12739672,-0.15689884,0.08608363,-0.036514066,-0.06717086,0.008247079,0.04062879,-0.034737114,0.02448503,-0.044377524,0.01557481,0.0124891475,0.02615734,-0.010668357,0.04831022,-0.018748444,-0.009800331,0.104969665,-0.09528123,-0.035487793,-0.008847765,0.03967268,-0.024461968,-0.023449136,0.02045891,0.04449667,0.0049896254,0.021328112,0.027709179,0.05103214,0.02169003,0.038540136,-0.030661404,-0.077295884,-0.063912265,0.050026916,-0.039529666,-0.05240804,0.034213174,-0.029113388,0.017797545,0.0889019,0.025597027,0.037038065,0.074010946,0.08836489,0.012506197,-0.00912683,-0.022710713,-0.04744527,-0.022401297,-0.016295211,0.001067294,0.07291419,0.026708115,0.017435772,-0.021505568,0.036084928,0.0029056915,-0.07464157,-0.06495912,-0.048073094,-0.027286785,0.008152625,0.044885524,0.06855501,0.04161002,0.007927758,0.069308065,-0.062428303,0.014932932,0.0077264886,-0.0054486482,0.041268576,0.013923116,0.06384434,-0.14176434,-0.10656307,-0.05446938,-0.03462547,-0.0057929642,-0.009498951,-0.050225142,-0.060978338,0.02113953,-0.09934114,0.050309416,0.098458834,0.018190298,0.014802722,0.005485406,-0.016634637,-0.011028203,0.034201797,0.09116439,-4.435896e-08,0.058244374,-0.04757842,-0.031434808,-0.09368488,-0.04600906,0.03145487,-0.026517933,0.03203284,-0.025377668,-0.02932302,0.0059357947,0.038283724,-0.024181461,0.026233431,-0.0976527,0.076294556,-0.08023676,-0.03985825,0.008215359,0.021914857,-0.16837847,0.021716716,-0.0915865,0.0994579,-0.004247042,-0.100894056,0.027892467,0.040797647,-0.03053547,-0.034262165,0.005276381,0.08017915,-0.09768335,-0.03142812,-0.0037523822,-0.010571114,0.020949699,-5.8065714e-05,0.06871681,0.0008046486,0.06614357,-0.01842056,-0.04156335,-0.00015354475,-0.04754194,-0.010409661,-0.0332973,0.0010426778,-0.074585594,0.053796906,0.05677689,0.008837967,-0.051348582,-0.108834796,-0.11232588,-0.02697968,-0.023660162,-0.052339684,-0.0010274275,-0.05167324,-0.027321007,-0.029924689,0.14409024,-0.030691946 +4.2.3.212,"The enzyme is involved in the biosynthesis of sesquiterpenoids from (2E,6E)-farnesyl diphosphate in fungi such as Boreostereum vibrans and Coniophora puteana.",384,1.0,-0.023431616,-0.026915053,-0.084731065,-0.012381606,0.002173206,0.041736104,-0.08323604,0.08399856,0.10246309,-0.018221159,0.045505695,-0.072322205,-0.02657287,-0.062167473,-0.06515968,0.02017506,0.010705727,0.03130962,0.022138843,-0.01525902,0.09173288,0.07637215,-0.026886085,0.03145387,0.059146654,-0.008797405,0.0094502065,-0.005072179,0.024966212,-0.08558183,-0.05914437,-0.015326512,0.04403963,-0.06569524,0.030652832,0.08560654,-0.010262597,-0.032708302,0.06393698,0.026946684,0.016520202,-0.02198193,0.018487882,-0.03406112,-0.11396024,-0.011532,0.039756976,0.041800253,0.047987957,-0.0010995365,-0.042127296,-0.075883664,-0.030266797,-0.023341013,0.003329049,-0.007889029,-0.0033328796,-0.03250436,-0.036963638,0.06524882,0.043911602,0.007896029,0.040683765,0.009904218,-0.03333984,-0.056196816,-0.0033502413,0.015583263,-0.011796279,-0.08659376,-0.11629047,-0.022562495,-0.019726845,-0.01761898,-0.07251678,0.09863039,-0.019639704,0.018878626,0.024818713,-0.08874884,0.03874315,-0.033987574,0.032172788,0.04169505,0.02560092,0.013256232,0.018211257,0.0022849464,0.05615088,0.049749903,0.06489369,0.004313744,0.0017080669,-0.08615732,-0.07099919,0.075864345,0.02641989,0.07306159,-0.012096908,-0.030288624,0.05594909,0.036922913,-0.032983214,-0.05621859,-0.031548113,-0.032910146,-0.060246754,-0.009708186,0.034053598,-0.03751684,0.023879446,0.0032816757,0.05725019,-0.034102872,-0.035546277,0.08118054,0.039511137,-0.05828584,0.015487446,-0.013757239,-0.014861584,0.01828997,-0.024292191,0.0510383,0.03829584,0.027459767,-0.041052256,3.2126172e-33,0.08111207,0.074432045,0.011033804,0.031949524,-0.08323019,-0.009361365,-0.032478977,0.093482435,-0.109286815,-0.0062490655,-0.09821884,-0.08846305,0.043593217,0.011484116,0.051927775,0.016074922,0.053358477,-0.049286313,0.08815814,-0.045729153,0.03475818,0.002628796,-0.05337728,-0.007043147,0.006682551,0.038681053,0.008957989,-0.007797141,0.030899405,-0.038987197,0.072725326,-0.057142418,-0.036085084,-0.01729414,0.10425723,-0.104120634,-0.0017986561,0.0010425168,-0.109573826,-0.023932673,0.0004934003,0.071677424,-0.06747698,-0.010982028,0.0695412,-0.07458523,-0.0049366206,0.047860976,0.15847747,0.014587511,0.009722206,-0.001811935,0.14845602,0.025944341,-0.025160793,0.010129264,-0.023424849,-0.009862014,-0.020299401,0.051365238,-0.012673465,-0.0126392,-0.04181992,-0.012011487,0.051285166,0.0662895,-0.08526706,-0.0416167,0.013354804,0.0831172,-0.04298179,-0.038332045,-0.043755922,-0.025313444,-0.00079649844,-0.008790411,-0.078278646,-0.038316354,-0.003734016,0.016795479,0.03154519,-0.03829108,0.019955216,-0.06673871,-0.053194758,-0.038734086,-0.0074302894,-0.0043850993,0.0149454335,0.031265672,0.045234993,-0.092695355,-0.05186203,0.0067423657,0.00080565433,-4.1053317e-33,0.029334584,-0.0769157,0.016008107,-0.031768512,-0.0034911837,0.060752716,-0.0111668855,0.0040573166,-0.030081835,-0.003761211,0.00087287946,0.017731315,0.09352891,-0.035569753,-0.010482265,0.0013839728,-0.0049494677,0.080139555,0.036192063,-0.029041978,-0.020135297,0.08232508,0.059098516,0.022520874,0.040962517,-0.0035349077,0.033199888,-0.00613027,-0.115032814,0.12698716,0.017117638,0.0021650698,-0.02393691,0.06126121,-0.086084366,0.041551493,-0.059538633,0.019489333,0.059082426,0.07343973,-0.06277699,0.030287843,0.031079369,0.057942532,0.05747003,-0.021277387,-0.15788601,0.06564985,-0.033062957,-0.05325828,-0.01617237,0.011921929,-0.014601085,0.007779827,0.024933504,-0.055903815,-0.06973424,-0.01910781,-0.001129042,-0.046826106,-0.026761705,-0.053910375,-0.036190752,-0.0464428,0.08474426,0.06816286,-0.073728785,0.043558862,0.021931536,-0.0034645868,0.050179437,0.037230626,-0.014442047,0.024953187,0.009840206,-0.013490919,0.011620904,-0.062662795,-0.006252311,0.0064345286,-0.0432142,-0.0010163214,0.055785906,-0.0797982,-0.0685105,-0.05496437,0.086173326,0.07797819,0.0025134396,0.03694695,-0.03646797,-0.005693787,0.013818163,0.066268295,0.10152301,-3.214541e-08,0.06628574,-0.040049773,0.042972483,-0.0135380775,-0.007997534,-0.024083214,0.02343042,0.05636292,0.00740323,0.047574054,-0.059794325,0.04703169,0.055253632,0.011958111,0.13713342,-0.008926039,0.046782773,0.046879712,-0.05646169,0.015024831,0.052607905,-0.026015943,-0.08465295,0.058486428,0.06233186,-0.10910469,-0.027780637,-0.026433855,0.041989505,0.034173537,0.055901047,-0.041244548,0.02142303,-0.06957476,-0.08962621,0.06566093,-0.051855363,-0.044090193,-0.021743314,0.036337964,0.008313534,-0.07170591,-0.06426561,0.0036127209,-0.09037309,0.029162621,0.020681957,0.03513427,-0.0056163855,0.027769083,-0.010046518,-0.037324693,-0.031095775,0.0041045006,-0.05183921,-0.10123717,0.023186313,0.014597777,-0.030321484,-0.035549376,-0.05196149,0.056203317,0.1937795,-0.057928402 +4.2.3.213,"Isolated from Colletotrichum gloeosporioides, a pathogenic fungus that causes bitter rot in variety of crops.",384,1.0,0.004206012,-0.04520676,-0.10816548,0.013263001,0.09228038,-0.03372379,-0.04437586,0.090958275,0.039217673,-0.024341526,0.06205033,0.040501084,-0.015605667,-0.05169583,-0.11071621,-0.0403855,0.048140462,0.02978868,-0.025135197,-0.05675784,0.027012495,0.10037066,-0.055917654,0.015240229,0.054804616,-0.01899431,-0.021132916,-0.008669131,-0.038647227,-0.08435619,0.023396522,0.07484384,0.10562797,-0.0071100416,0.025445268,0.05271765,0.014722682,-0.029633667,0.06559411,-0.017170765,-0.035213053,-0.015655523,0.091477275,-0.029226001,-0.05326974,0.027597236,-0.058815062,0.08839899,0.06630371,-0.018152019,0.0013597861,-0.034022823,0.011265691,0.044812683,-0.023808073,0.052950874,-0.016449792,-0.01825693,-0.0010692333,0.0157946,0.019621857,0.012070426,0.03289835,0.016490959,-0.07075846,-0.0033941437,-0.009441025,0.0062293047,0.022023538,-0.026847979,-0.016205598,0.00045698805,0.010270683,0.029921101,-0.059382465,0.09408445,-0.045077253,-0.017027851,0.09664189,0.05068608,0.0082477825,0.06895149,0.118206,-0.026283747,-0.013727461,-0.014965172,0.02267099,0.017026786,0.024562024,0.002058352,0.015134609,-0.007943334,0.08598547,0.035498206,-0.09490683,0.10957705,0.11165151,-0.04563977,-0.022118686,0.0023340888,-0.017187154,-0.038133487,0.040910553,-0.034425464,-0.037626877,0.025891012,-0.019310316,-0.054134596,0.03669286,-0.009146728,0.0036936265,0.037145954,-0.012691817,-0.08174358,0.022397114,-0.073764674,0.0809645,-0.04618305,-0.06985108,-0.016360626,-0.038280074,-0.011486515,-0.036517326,-0.030492598,-0.0046940716,0.037931845,0.012504256,1.0754301e-33,0.0070971604,-0.0035694074,-0.05233389,-0.043879673,0.074688286,-0.07079521,0.009058679,0.026754335,-0.06350881,-0.02838498,-0.07469685,-0.05962102,-0.06442584,-0.0069579775,-0.029575601,0.07174494,-0.006441712,-0.027471125,0.05973533,0.025995415,0.020379338,0.01178294,-0.010015521,-0.005612884,-0.015673745,0.048943143,0.020151714,-0.036500182,0.064415805,0.011640558,0.0063568074,-0.020697525,-0.008897762,0.01082992,0.011869084,-0.0047041425,-0.104230456,-0.049797125,-0.05806788,0.050749034,-0.020124467,0.051854722,0.010611704,-0.03936753,0.057567798,-0.035490382,-0.012594713,0.045460925,0.06901557,0.017071983,-0.0028505912,0.04514246,0.09122434,0.045969505,0.021645159,-0.011327692,0.020882897,0.039705653,0.042553876,0.015379517,-0.06728594,0.12992363,-0.032574177,-0.018105172,0.00071781594,-0.0066603897,-0.09977137,0.0072611584,-0.02209198,-0.003464085,0.039538816,-0.025881859,-0.15168978,-0.01952427,-0.04245881,-0.05308942,0.057282273,0.024600143,-0.044830553,-0.010211573,-0.01934363,-0.1099781,-0.019701732,0.018338298,-0.0960128,0.063214995,-0.051104393,-0.012910998,0.0060021915,0.036272574,-0.009560694,-0.015378606,-0.018181201,0.07751279,0.009252007,-1.5345868e-33,0.101363644,-0.026092807,0.0014495667,0.053868543,0.007987903,0.10152197,-0.09403335,-0.007517124,-0.005249696,0.007659667,-0.06697976,0.047545347,-0.024613263,0.0037766355,-0.041930392,0.029697724,0.11940906,0.083763674,-0.05359868,-0.021253634,-0.037719384,0.09752297,-0.0017869215,-0.056480613,0.02894193,-0.01700451,0.06524888,0.007328084,-0.1566309,0.01721495,0.05481389,0.014128919,0.045166645,-0.03276024,-0.058582183,-0.024989372,-0.06502785,-0.105099805,0.0221812,0.014971217,-0.017920693,0.025444277,0.032197233,0.03372797,0.082240894,-0.012274199,-0.0865589,0.029912425,0.049259543,0.066202186,0.02389942,0.008386314,0.015995625,0.05054654,0.06362108,-0.083530635,0.020160515,0.04875234,-0.032449417,-0.0061754333,-0.05348466,-0.0033738033,-0.091782115,0.0112161655,0.16508423,0.061918005,-0.08433812,0.021139836,-0.03625935,0.02662396,0.05434605,0.0254507,0.020618327,0.012391074,0.03930715,0.0522249,-0.037795253,0.06129175,-0.020138262,0.004973264,-0.012584545,-0.06550226,0.13072747,-0.083730265,-0.046426706,-0.07139616,-0.008769245,0.060773727,0.028871156,0.04943484,-0.026329467,-0.013975292,-0.042008262,-0.051059164,0.12010712,-2.442237e-08,0.0404744,-0.0109886145,-0.09282196,-0.056201275,0.0027986984,-0.047544483,0.044897027,0.037304357,0.030236185,0.06975177,-0.052191213,0.08962491,0.03489507,0.03692965,0.07036893,0.013856985,0.012644018,-0.05664984,-0.027305378,0.0501411,-0.042177007,-0.036962144,0.0047264327,0.031660147,-0.035370685,-0.06376792,0.069986954,-0.021040631,0.029493192,0.014346114,-0.017399674,0.053864177,-0.021483596,-0.08366704,-0.031415597,0.04008203,-0.030297112,-0.032768305,-0.00339873,0.03258636,-0.07265035,0.02548875,0.016130958,-0.08692414,-0.15811224,-0.017815309,0.021743417,0.08485942,-0.023332667,-0.023210814,-0.016896985,-0.037538998,-0.027735999,0.007878386,-0.054153785,-0.06790076,0.09065956,-0.040427055,0.020434335,-0.06606422,-0.047065675,-0.055832762,0.09862954,0.011680648 +4.2.3.214,"Isolated from Colletotrichum gloeosporioides, a pathogenic fungus that causes bitter rot in variety of crops.",384,1.0,0.004206012,-0.04520676,-0.10816548,0.013263001,0.09228038,-0.03372379,-0.04437586,0.090958275,0.039217673,-0.024341526,0.06205033,0.040501084,-0.015605667,-0.05169583,-0.11071621,-0.0403855,0.048140462,0.02978868,-0.025135197,-0.05675784,0.027012495,0.10037066,-0.055917654,0.015240229,0.054804616,-0.01899431,-0.021132916,-0.008669131,-0.038647227,-0.08435619,0.023396522,0.07484384,0.10562797,-0.0071100416,0.025445268,0.05271765,0.014722682,-0.029633667,0.06559411,-0.017170765,-0.035213053,-0.015655523,0.091477275,-0.029226001,-0.05326974,0.027597236,-0.058815062,0.08839899,0.06630371,-0.018152019,0.0013597861,-0.034022823,0.011265691,0.044812683,-0.023808073,0.052950874,-0.016449792,-0.01825693,-0.0010692333,0.0157946,0.019621857,0.012070426,0.03289835,0.016490959,-0.07075846,-0.0033941437,-0.009441025,0.0062293047,0.022023538,-0.026847979,-0.016205598,0.00045698805,0.010270683,0.029921101,-0.059382465,0.09408445,-0.045077253,-0.017027851,0.09664189,0.05068608,0.0082477825,0.06895149,0.118206,-0.026283747,-0.013727461,-0.014965172,0.02267099,0.017026786,0.024562024,0.002058352,0.015134609,-0.007943334,0.08598547,0.035498206,-0.09490683,0.10957705,0.11165151,-0.04563977,-0.022118686,0.0023340888,-0.017187154,-0.038133487,0.040910553,-0.034425464,-0.037626877,0.025891012,-0.019310316,-0.054134596,0.03669286,-0.009146728,0.0036936265,0.037145954,-0.012691817,-0.08174358,0.022397114,-0.073764674,0.0809645,-0.04618305,-0.06985108,-0.016360626,-0.038280074,-0.011486515,-0.036517326,-0.030492598,-0.0046940716,0.037931845,0.012504256,1.0754301e-33,0.0070971604,-0.0035694074,-0.05233389,-0.043879673,0.074688286,-0.07079521,0.009058679,0.026754335,-0.06350881,-0.02838498,-0.07469685,-0.05962102,-0.06442584,-0.0069579775,-0.029575601,0.07174494,-0.006441712,-0.027471125,0.05973533,0.025995415,0.020379338,0.01178294,-0.010015521,-0.005612884,-0.015673745,0.048943143,0.020151714,-0.036500182,0.064415805,0.011640558,0.0063568074,-0.020697525,-0.008897762,0.01082992,0.011869084,-0.0047041425,-0.104230456,-0.049797125,-0.05806788,0.050749034,-0.020124467,0.051854722,0.010611704,-0.03936753,0.057567798,-0.035490382,-0.012594713,0.045460925,0.06901557,0.017071983,-0.0028505912,0.04514246,0.09122434,0.045969505,0.021645159,-0.011327692,0.020882897,0.039705653,0.042553876,0.015379517,-0.06728594,0.12992363,-0.032574177,-0.018105172,0.00071781594,-0.0066603897,-0.09977137,0.0072611584,-0.02209198,-0.003464085,0.039538816,-0.025881859,-0.15168978,-0.01952427,-0.04245881,-0.05308942,0.057282273,0.024600143,-0.044830553,-0.010211573,-0.01934363,-0.1099781,-0.019701732,0.018338298,-0.0960128,0.063214995,-0.051104393,-0.012910998,0.0060021915,0.036272574,-0.009560694,-0.015378606,-0.018181201,0.07751279,0.009252007,-1.5345868e-33,0.101363644,-0.026092807,0.0014495667,0.053868543,0.007987903,0.10152197,-0.09403335,-0.007517124,-0.005249696,0.007659667,-0.06697976,0.047545347,-0.024613263,0.0037766355,-0.041930392,0.029697724,0.11940906,0.083763674,-0.05359868,-0.021253634,-0.037719384,0.09752297,-0.0017869215,-0.056480613,0.02894193,-0.01700451,0.06524888,0.007328084,-0.1566309,0.01721495,0.05481389,0.014128919,0.045166645,-0.03276024,-0.058582183,-0.024989372,-0.06502785,-0.105099805,0.0221812,0.014971217,-0.017920693,0.025444277,0.032197233,0.03372797,0.082240894,-0.012274199,-0.0865589,0.029912425,0.049259543,0.066202186,0.02389942,0.008386314,0.015995625,0.05054654,0.06362108,-0.083530635,0.020160515,0.04875234,-0.032449417,-0.0061754333,-0.05348466,-0.0033738033,-0.091782115,0.0112161655,0.16508423,0.061918005,-0.08433812,0.021139836,-0.03625935,0.02662396,0.05434605,0.0254507,0.020618327,0.012391074,0.03930715,0.0522249,-0.037795253,0.06129175,-0.020138262,0.004973264,-0.012584545,-0.06550226,0.13072747,-0.083730265,-0.046426706,-0.07139616,-0.008769245,0.060773727,0.028871156,0.04943484,-0.026329467,-0.013975292,-0.042008262,-0.051059164,0.12010712,-2.442237e-08,0.0404744,-0.0109886145,-0.09282196,-0.056201275,0.0027986984,-0.047544483,0.044897027,0.037304357,0.030236185,0.06975177,-0.052191213,0.08962491,0.03489507,0.03692965,0.07036893,0.013856985,0.012644018,-0.05664984,-0.027305378,0.0501411,-0.042177007,-0.036962144,0.0047264327,0.031660147,-0.035370685,-0.06376792,0.069986954,-0.021040631,0.029493192,0.014346114,-0.017399674,0.053864177,-0.021483596,-0.08366704,-0.031415597,0.04008203,-0.030297112,-0.032768305,-0.00339873,0.03258636,-0.07265035,0.02548875,0.016130958,-0.08692414,-0.15811224,-0.017815309,0.021743417,0.08485942,-0.023332667,-0.023210814,-0.016896985,-0.037538998,-0.027735999,0.007878386,-0.054153785,-0.06790076,0.09065956,-0.040427055,0.020434335,-0.06606422,-0.047065675,-0.055832762,0.09862954,0.011680648 +4.2.3.215,"Isolated from the fungus Colletotrichum gloeosporioidea. delta-Araneosene may be involved in the biosynthesis of dolasta-1(15),8-diene (see EC 4.2.3.214, dolasta-1(15),8-diene synthase) and cycloaraneosene (see EC 4.2.3.191, cycloaraneosene synthase).",384,1.0,-0.07335469,-0.008847451,-0.12121659,-0.014472663,0.026947979,-0.025928918,-0.051848646,0.07021083,0.07604327,-0.02639207,0.0067888596,0.006353281,-0.07519452,-0.0031346204,-0.1071463,-0.00347422,-0.027946027,0.06652268,-0.026163852,-0.07589895,0.05434507,0.016009778,0.017185422,-0.025898248,0.045856424,-0.008444536,0.008883869,-0.036188915,0.015634963,-0.07633871,-0.057275426,-0.0069298553,0.03431069,-0.06295327,0.0020259698,0.059763707,-0.04791481,-0.0036935234,0.054683045,0.049582325,0.0023939994,0.008891558,0.038186356,-0.05003982,-0.10534312,-0.040884264,-0.06666211,0.03164465,0.005708293,0.0127564855,-0.024239872,-0.049571406,-0.057432685,0.010749167,0.06169787,0.03312325,-0.03198461,0.0145575395,0.015045885,0.030949263,0.069593206,0.027725736,0.0042660073,0.0025624868,-0.072574645,-0.026386967,-0.025320003,0.033616755,-0.012081656,-0.034709554,-0.026168806,-0.022677692,-0.017924976,0.07100698,-0.052467722,0.08658353,0.019982327,0.04058561,0.06201826,0.02888116,0.058218647,0.0154463565,0.012391033,0.04756666,0.020197604,0.037913106,-0.046269078,0.12773111,0.06913493,-0.015502915,0.02449328,0.069002636,-0.04198831,-0.00055332034,-0.03476607,0.1000386,0.056223284,0.051119275,0.004845975,-0.00022427687,0.040757764,-0.051993866,0.041249655,-0.028634299,-0.080670886,-0.035006166,-0.009818716,-0.033536296,0.03404119,0.016515289,0.029642982,-0.022201711,0.038558453,-0.021919303,-0.029338961,-0.005032873,0.044094596,-0.03420754,0.00039584044,-0.04622421,-0.025330113,-0.013444166,0.041855317,0.009740124,0.052324116,-0.013028759,-0.08129065,1.2072896e-33,0.06733152,0.021703407,-0.047805905,0.014679051,0.07507821,-0.05666511,0.073973395,0.004883822,-0.11644752,-0.0022854256,-0.116643876,-0.076541185,-0.059907433,-0.023014966,-0.047870267,0.06587928,0.099578924,-0.04551508,0.0015516387,-0.04041939,0.052581005,0.061857563,-0.04297533,0.032287773,0.055630654,0.021191135,-0.049526636,-0.01116216,0.071960896,-0.013192904,-0.04659384,-0.08137308,-0.024007775,0.025311593,0.015839424,0.012571471,-0.11540707,-0.022428777,-0.059533603,0.059048284,0.06675726,0.025743155,-0.009013303,-0.011810508,0.061482675,0.044572413,-0.072932765,0.027836798,0.09282876,0.0040118005,-0.033103783,0.039052248,0.06512806,0.024763377,-0.09871543,0.018086301,-0.04221048,0.021055978,0.06428758,0.0699667,-0.046395425,0.08778248,-0.050946906,0.032212034,0.03929724,0.04891524,-0.12493689,-0.010864177,-0.01314196,-0.017091267,0.006650785,-0.08937657,-0.051764723,-0.042661566,0.039033443,0.014177906,0.0062189237,-0.0050139455,-0.059257932,-0.025325373,0.016511098,-0.021204311,0.032560267,-0.0048483866,-0.051295202,0.018135589,-0.021657327,-0.021603994,-0.0033476523,0.050536755,0.01770404,-0.07228873,-0.06598158,0.03133315,0.008836411,-2.5314726e-33,0.07118268,-0.020172266,0.062993534,-0.078495234,-0.028563999,0.11009406,-0.07368773,-0.022165077,-0.0011683524,0.016045751,-0.006335841,-0.021820897,0.004077028,-0.03781676,-0.049421694,-0.032999143,0.05141187,0.10459065,0.01568556,0.039233305,-0.058888562,0.09795329,-0.02424647,-0.0077258693,0.029707216,-0.029735016,0.07549842,0.04304485,-0.087189294,0.011752978,-0.015894227,0.010908204,0.042553052,-0.042353157,-0.10124568,-0.0300112,-0.023195125,-0.08647685,0.047119655,0.060617056,-0.044364534,-0.029568193,0.03760732,0.09756079,0.06596826,0.022274515,-0.067906804,0.018581804,-0.019071031,-0.013849689,0.018845193,-0.013908311,0.015446028,0.011831893,0.0815892,-0.01741332,0.077243865,0.08810503,0.04525389,-0.055127643,-0.017611442,-0.0839367,-0.06734543,0.031391833,0.1596327,0.13950391,-0.06980244,0.030455122,-0.0027065915,0.016797328,0.057851397,0.04414881,-0.04631067,0.057986677,0.046740126,0.007029033,-0.05849769,-0.080943935,0.016784145,-0.0082726525,-0.038665116,-0.03363138,0.05897984,-0.08499016,0.015083531,-0.062997974,0.07041317,0.07715812,0.011108264,0.07095544,-0.018510763,0.029454473,-0.08820247,0.055215936,0.06428605,-3.9096236e-08,0.023510275,0.0056366017,-0.10275519,-0.055427585,-0.03102371,-0.06726078,0.05525106,0.05881693,0.072964415,0.06308109,-0.09883085,0.027603861,0.05900272,0.0120660355,0.06944862,0.03451368,-0.040859133,-0.0058452175,-0.026542392,-0.006099403,0.0069559575,0.032988142,-0.02254054,0.025129229,0.025596708,-0.12625292,0.004029949,0.03589977,0.02067451,-0.027587414,-0.06361177,0.03499641,0.03455312,-0.043335486,-0.0029911543,-0.014668813,-0.035991084,-0.03355892,0.01397576,-0.002607912,0.02604572,-0.048672125,0.032360666,0.0053084265,-0.07529528,-0.021309711,0.0029212295,0.038432956,0.03572401,-0.03674031,0.0021448098,0.01609401,-0.023998693,-0.09238212,-0.0707847,-0.08751373,0.013787615,0.048260342,-0.051596355,-0.03665762,-0.05693351,-0.031004705,0.18273489,-0.02824298 +4.2.3.216,"A sesterterpenoid synthase enzyme isolated from the bacterium Streptomyces somaliensis. The enzyme also produces somalensene B (cf. EC 4.2.3.217, somaliensene B synthase).",384,1.0,-0.033500694,0.009500687,-0.1522718,0.03865512,-0.046593953,0.07226552,-0.123383,0.03642982,0.08233264,-0.04579133,0.011955396,-0.056134447,-0.006027798,-0.05142632,-0.06201094,0.009344807,-0.020429531,-0.0044097123,0.09273687,-0.028241368,0.07501922,0.080455214,0.06369297,0.002695236,0.08661141,0.028712148,0.02750546,-0.050402746,0.0024054723,-0.10471358,0.033707887,-0.03779854,0.047146786,-0.040241826,0.08635333,0.04178641,-0.03222131,0.012823882,0.100341186,0.076054215,0.024832467,-0.042067356,0.012080233,-0.03724451,-0.05849209,-0.0022633686,-0.0065200455,0.07837846,-0.028243273,-0.014398514,-0.04602973,-0.06811816,-0.06728121,0.0049650064,0.054443866,-0.023766864,0.0038190545,-0.02268635,-0.0011648627,0.021908754,0.10103821,0.040640283,0.02284663,-0.071588434,-0.010682521,-0.008063896,0.021837095,-0.04749552,0.027314514,-0.028190657,-0.075056195,-0.04263488,-0.026898421,0.08167712,-0.034771323,0.019763302,-0.01831231,0.019329589,0.020484531,0.0057158307,0.053518422,-0.03703918,-0.024358021,0.081723444,0.021691594,-0.016878737,0.009491635,0.09151751,0.046008218,0.0015078126,0.05460279,-0.0030456302,-0.037059728,-0.044587612,-0.019208515,0.010164663,-0.025066173,0.07178026,0.044986557,-0.021051249,-0.015598951,-0.030638557,-0.01329102,-0.016542349,-0.024811208,0.0048910445,0.0066508157,-0.02583253,0.1293314,-0.07658055,-0.007240935,-0.009155589,-0.054766163,-0.03686025,0.005227556,0.01983881,0.06334616,-0.029757556,-0.03411519,0.0015968374,0.0038458365,0.046640303,0.024597624,0.047023457,0.012229859,0.029225482,-0.071908996,1.1797864e-33,0.061692275,0.07413321,0.021609971,-0.025947014,-0.021390397,0.0261367,-0.001483469,0.07787514,-0.07613456,-0.118925065,-0.07837132,-0.13650136,-0.005104154,0.099778056,0.07384586,-0.045987524,0.016495368,-0.011493828,0.083456114,-0.10936116,0.020175498,-0.017383134,-0.05515547,0.012598632,0.03836885,0.012394691,0.039779615,0.006434308,0.12146984,-0.044488546,0.032005772,-0.045652967,-0.06518748,-0.065243244,0.022329139,-0.06923869,-0.08490861,-0.015843652,-0.058473207,0.03236955,-0.0071102353,0.03349563,-0.0106230825,0.0054065147,0.030051554,-0.010555142,-0.065117806,0.043508716,0.14729907,-0.01272203,-0.006090102,0.030293042,0.0877044,-0.0027807876,-0.09116659,0.04789967,-0.016001761,0.03357911,0.023141554,0.049513623,0.021863487,0.07468535,-0.019197915,-0.00064580765,0.023330092,0.050950456,0.0038031803,-0.00012485903,-0.018716019,0.023904458,-0.037766345,-0.031710308,0.026898153,-0.029838383,-0.037930917,0.03167521,-0.15024596,-0.018507382,0.031642005,-0.08712827,-0.04906026,-0.0042791073,-0.0014832647,-0.06589872,-0.07717174,-0.010587647,-0.026887938,-0.0351216,0.018760532,0.09374808,-0.007374389,-0.10471821,-0.111065246,0.018216548,0.0007866152,-1.4221211e-33,0.047470704,-0.075819984,-0.001349063,-0.025779784,-0.061650455,0.08358998,0.029189192,0.009107096,-0.07815521,0.012114484,0.043396022,0.008858049,0.09871086,-0.041434843,0.033597633,-0.01841356,-0.005519555,0.09406892,0.03642129,0.006378909,0.07185649,0.0702446,0.012053392,0.035408758,-0.015774205,0.014648866,0.04774669,0.037030086,-0.028865822,0.05974282,0.01771593,-0.025125982,-0.014198739,-0.035074715,-0.1027492,0.101137035,-0.041506197,-0.000524193,0.011720255,0.020102805,0.0097139245,0.056544896,-0.0013754007,0.11258654,0.12570806,0.005166871,-0.048047848,0.03970907,0.02644839,-0.04160846,-0.017588243,0.046328392,-0.002107164,-0.06649282,0.011669156,-0.033583503,-0.047918476,-0.04940539,-0.021812517,-0.088759705,-0.06602759,-0.048323307,0.0024808797,-0.02916556,0.08002698,0.048976827,-0.025466934,0.044985447,0.108397566,-0.038090948,0.044261612,0.011633747,-0.034414317,0.05353696,-0.016358903,0.0163835,-0.020372005,-0.034005467,-0.006482393,-0.010810782,0.011050377,-0.028418368,0.07684637,-0.062366392,-0.016379943,-0.04708704,0.10836553,0.045960832,0.003321938,0.107711904,-0.027945118,0.007983048,-0.06638573,0.058311377,0.039952587,-2.7690279e-08,0.036125183,0.0022531608,0.08868907,0.010435864,0.06979865,-0.05229959,0.037798855,-0.05608279,0.039783258,-0.017395336,-0.096399546,-0.058965772,0.015851112,0.022814125,0.07084417,-0.015550053,-0.04019145,0.0037243888,-0.012517661,-0.0454596,-0.024470428,0.012424504,-0.053333733,0.03170644,0.0388735,-0.06827504,-0.0077535366,0.02726611,0.05463957,0.037020314,0.049394038,0.01897947,0.0077480488,0.0020137783,-0.038529646,-0.01637461,-0.04944736,-0.01464819,0.04152104,0.04362951,-0.0052030133,-0.079565965,-0.028065061,0.03893789,-0.041297276,0.007837158,-0.028090142,-0.057937637,-0.032179948,-0.013062835,0.057007775,-0.036168423,0.02184756,0.015311924,-0.07952291,0.0012286576,-0.071069606,-0.009806486,-0.045778714,-0.0666195,0.031157091,-0.028999902,0.17888808,0.024741076 +4.2.3.217,"A sesterterpenoid synthase enzyme isolated from the bacterium Streptomyces somaliensis. The enzyme also produces somaliensene A (cf. EC 4.2.3.216, somaliensene A synthase).",384,1.0,-0.048036084,0.011006683,-0.12638582,0.038869634,-0.07765233,0.047664445,-0.12209504,0.014382811,0.07468227,-0.03722193,0.009963036,-0.09343993,-0.01148544,-0.06577791,-0.06641725,-0.0023128383,-0.0329562,-0.017284034,0.09952473,-0.043946765,0.041432235,0.088611245,0.039443474,-0.014052915,0.0883739,0.023974756,0.033342607,-0.011017709,-0.005494451,-0.08860806,0.031973112,-0.041717738,0.034728803,-0.036786087,0.094938904,0.07020063,-0.044431407,0.0063302084,0.105120786,0.09271953,0.06138708,-0.04009925,0.03848774,-0.042264175,-0.068072565,-0.007687556,0.0019984685,0.079637535,-0.032998025,-0.02133857,-0.050703917,-0.092118226,-0.0679985,0.021274837,0.058342267,-0.03425139,0.050873637,-0.01942474,-0.018016884,0.0075037195,0.07732866,0.03925749,0.0141575,-0.056132637,-0.03630164,-0.047888044,0.021159807,-0.048401307,0.00090339076,-0.032986816,-0.09639533,-0.05662403,-0.01785382,0.04719691,-0.03731248,0.013981008,-0.005097752,-0.011777937,0.03467187,0.009524906,0.048482455,-0.010481257,-0.025132034,0.052938797,0.041860837,-0.008114746,0.019143416,0.05826261,0.032471884,-0.012768346,0.046050664,0.00961524,-0.043406565,-0.043430507,-0.01706244,0.015074491,-0.0320231,0.07751978,0.01973942,-0.008921525,-0.008670506,-0.015837103,0.004860371,-0.046982884,-0.040701326,0.01860506,-0.0012277215,-0.001474366,0.10006739,-0.06606662,-0.036506206,0.008397723,-0.071172275,-0.05276711,0.013963246,0.01307525,0.033183858,-0.028037408,-0.011914177,0.022647893,-0.020224305,0.029571554,0.047789786,0.030669725,0.0035633363,0.034369275,-0.06456747,9.4379334e-35,0.06379962,0.07891621,0.008663377,-0.024801912,0.008629818,0.037340518,-0.03839705,0.077612184,-0.103034526,-0.12057926,-0.06189061,-0.12082277,-0.023922797,0.10369081,0.07117223,-0.03114122,0.011073098,0.0051009827,0.061419502,-0.09559185,0.04146391,-0.037028834,-0.060122237,0.012204668,0.013686571,0.006901391,0.025194928,-0.007509808,0.083740056,-0.040313028,0.013982412,-0.011406754,-0.070429064,-0.088337496,0.0028649976,-0.06522515,-0.07037363,-0.023003044,-0.05964396,0.021983806,-6.7100205e-05,0.043485086,0.01980106,-0.034399446,0.052635618,-0.0006806427,-0.060979526,0.012962705,0.13815755,0.008850493,0.0071532875,0.0117105935,0.12513,-0.0052199126,-0.07650843,0.04036236,-0.01478717,0.022984289,0.033735547,0.056377005,0.006463372,0.09014579,-0.019015046,-0.0289169,0.01725145,0.061039813,0.0073457304,-0.01017003,-0.0065778764,0.044491045,-0.02546845,-0.02410685,0.013060115,-0.01736755,-0.013347447,-0.0010903877,-0.13696603,-0.007844691,0.024731463,-0.06532131,-0.03905119,0.0052642957,0.013847032,-0.06976298,-0.0795874,-0.03257413,-0.034440883,0.0013462232,0.015245175,0.07510574,0.0028219274,-0.07717773,-0.12917782,0.015941685,0.015365161,-7.877274e-34,0.06318128,-0.08534008,-0.0027518047,-0.047617067,-0.06364568,0.053993452,0.015270677,0.029172564,-0.06424069,-0.018729994,0.048872024,0.012503336,0.11257328,-0.05790567,0.020532185,-0.013972643,-0.023101458,0.09710954,0.045911405,0.017546698,0.08827879,0.051883314,0.0033597453,0.032056145,-0.0141856,-0.008048136,0.0489671,0.042362895,-0.012898502,0.031859957,0.0046794834,-0.037856556,-0.009915616,-0.00987816,-0.12611085,0.09151368,-0.053024698,0.005982111,0.023493363,0.035676077,0.068439305,0.089209124,0.0043701376,0.11437951,0.09799043,0.016403519,-0.04452315,0.050111357,0.0052073365,-0.03953214,-0.005032881,0.04138715,0.0069621387,-0.0573272,0.016810017,-0.00491902,-0.03362937,-0.04492789,-0.0056325053,-0.092816934,-0.093833074,-0.030832091,-0.0006016587,-0.020029252,0.074415214,0.06354291,-0.031661827,0.0641995,0.11842919,-0.02942979,0.061265077,0.045470223,-0.042839233,0.022521542,-0.014061756,0.02044976,-0.038912535,-0.016429238,-0.0026894496,-0.001740071,0.04224869,-0.051797386,0.066151716,-0.066788964,-0.028927816,-0.037210666,0.10598992,0.02153523,-0.012481318,0.10592874,-0.027121013,0.016013362,-0.058515202,0.07999507,0.03155569,-2.8114858e-08,0.032909963,-0.0014442594,0.09765682,0.0095051825,0.054586936,-0.036162894,0.049802355,-0.06301108,0.056589488,0.000712836,-0.07830037,-0.054925922,0.026214115,0.037342716,0.059862897,0.016883863,-0.034670606,-0.005434882,-0.0066395574,-0.0033417374,-0.023967642,0.029755553,-0.05683714,0.057250347,0.033974875,-0.051492,-0.004028758,0.00986477,0.018899422,0.05171451,0.04182417,0.03172422,-0.0028403911,0.012030354,-0.06205645,-0.0064460547,-0.06562571,-0.053670045,0.007325227,0.027236355,0.028354758,-0.07998746,-0.029764492,0.0035362814,-0.047144316,0.011456838,-0.03320397,-0.07125622,-0.032867454,-0.010408758,0.061144166,-0.014749998,0.037165035,0.004113489,-0.06351511,0.003655416,-0.047141384,-0.013672854,-0.050702468,-0.062306434,0.03353823,-0.03589516,0.20781593,0.04317976 +4.2.3.218,A diterpenoid synthase enzyme isolated from the fungus Aspergillus stellatus.,384,1.0,-0.07091178,-0.0112517215,-0.114768565,0.06105436,-0.0016959239,0.0036476136,-0.12025181,0.011829251,0.05383279,-0.012776438,0.040768117,-0.040274516,-0.020523956,-0.007213943,-0.095938794,0.029727139,0.006115515,0.018081648,0.044076055,-0.017442571,0.041025117,0.073135614,-0.03127821,0.041413814,0.0979562,-0.0033534006,0.07817185,-0.042866293,-0.045099564,-0.107032284,-0.05164227,-0.024640076,0.046878207,-0.03096554,0.034317233,0.03420774,-0.03803687,-0.00849478,0.10621793,0.03968437,0.05179461,-0.0125216665,0.055491295,-0.06297555,-0.068539016,0.0029191636,-0.07152943,0.05042845,0.06645546,-0.009475754,-0.069007605,-0.04988601,0.007212502,-0.035891283,0.04281359,0.011713086,0.07641115,-0.058818422,-0.051198825,0.0514288,0.030553063,0.05739516,-0.00025557648,-0.02772008,-0.07700222,-0.026130272,-0.006384589,-0.00048524997,-0.036790635,-0.08871167,-0.10868923,-0.054932766,-0.036654342,-0.025738213,0.022928849,0.021215938,-0.010127221,0.020714117,0.051168736,0.012656713,0.11445674,0.005983893,0.0095595475,0.03406607,0.03163686,0.02714344,0.045699153,0.024766104,0.07093012,-0.0004198993,0.0051521612,0.030387593,-0.049416192,0.005656447,-0.058601104,0.08064825,0.030640572,0.105683155,0.005131334,-0.037479367,0.042163778,-0.060807265,0.0125392275,-0.042046826,-0.020384682,-0.0063745677,0.030738018,-0.010291325,0.0325265,-0.016209645,0.054751437,-0.011310239,-0.018044624,-0.03195776,0.031443514,-0.038005915,0.043502204,-0.037768472,-0.041998178,0.01877162,0.019253971,0.038411044,0.026175871,0.04337899,-0.014635531,0.048859306,-0.014653157,1.0910177e-34,0.03651827,0.10583788,-0.03556708,0.03204725,0.00105261,-5.556027e-05,0.00537103,0.055138815,-0.070369475,-0.119235784,-0.06895372,-0.03500142,-0.06947213,0.05494756,0.06583708,-0.034320217,0.10169667,0.016460586,0.024409238,-0.021444334,0.042330183,0.015170512,-0.091998816,-0.024390815,0.035765227,0.0672744,0.0052868775,-0.047050178,0.09702648,-0.06257832,0.009512014,-0.06428914,-0.045251828,0.026045535,0.061838925,-0.03540984,0.0070325285,0.0023141706,-0.10546815,-0.0088941045,-0.01476072,0.027070275,-0.032870196,-0.069452114,0.028326638,0.0061850734,-0.040011846,-0.003095662,0.060844224,-0.013823095,0.0107640475,0.07316451,0.095910184,-0.0032980854,-0.032282494,0.022152428,-0.006810166,0.0064593856,0.027762236,0.03886327,-0.05494378,0.0829811,-0.08659616,0.013629918,-0.03816767,0.028918846,-0.026150817,-0.05244175,0.024427945,0.07276882,-0.030605242,-0.048698246,0.0045028334,-0.03032723,0.023719817,-0.019325858,-0.10403083,0.026878403,0.0052161734,-0.06419727,0.014842198,0.0014768529,0.011710299,-0.023019899,-0.069576226,-0.03847212,0.00039803833,0.04373173,-0.0010133516,0.044007286,-0.019887082,-0.055866234,-0.056447696,0.06802775,0.05431995,-1.7678838e-33,0.09866157,-0.120538145,0.05830183,-0.027916353,-0.065610886,0.094854616,-0.02520285,0.019097215,0.0047365003,0.002003836,0.008090649,-0.005639383,0.06164897,-0.016826903,-0.004169745,-0.009598414,0.00018771437,0.13332212,-0.003345286,-0.052108828,0.03347082,0.088787444,0.017371235,0.03563215,0.0070472956,-0.022676826,0.05652771,0.06938607,-0.04459744,0.038035534,0.010207768,0.018722454,0.03770267,-0.008323309,-0.12373415,0.11167626,-0.03752145,-0.0071561867,-0.027838701,0.0788787,-0.038298097,-0.02399031,-0.012548409,0.082911834,0.056049448,-8.844232e-05,-0.062117644,0.037773024,0.012972814,-0.02960226,0.04809178,-0.011851137,0.0033202656,-0.036465544,-0.022211267,-0.036607504,0.019355727,-0.017694093,0.046959758,-0.07112884,-0.05583244,-0.02892156,-0.03725398,0.018439658,0.018956468,0.03898373,-0.044771113,-0.0032177796,0.06735512,-0.01937492,0.05280447,0.08566178,-0.010384493,0.064637244,0.05646218,-0.008124614,-0.023281222,-0.04813035,0.020623304,0.049784113,-0.030551884,-0.062268704,0.06608974,-0.038128246,-0.07390623,-0.12279423,0.10743515,0.030080607,-0.08565969,0.070887,0.017751483,0.03738146,-0.09683148,0.06730785,0.06424211,-1.9839117e-08,0.06261598,0.04161901,0.032115143,-0.06818605,-0.02634266,-0.03625665,0.082233064,-0.041268826,0.0696599,0.025425877,-0.07852661,0.0116291735,-0.0110600805,0.07400545,0.067368604,0.014015524,0.0067357463,-0.03650205,0.012250382,0.05707168,0.06450279,0.008984907,-0.06809366,-0.0051075094,-0.0027121562,-0.105202265,0.025438134,0.0017309198,-0.01101718,0.048615113,-0.023462603,0.05288276,-0.021977136,-0.05568096,-0.045957524,-0.027938714,-0.0059773996,-0.08527396,0.009911158,0.046874203,0.0050191726,-0.051554687,-0.0687106,-0.025494996,-0.091949224,-0.032804154,-0.013472474,-0.06871344,0.014592595,-0.010673228,0.04416367,0.006968748,0.007845928,-0.08104401,-0.08039494,-0.014753141,0.032086086,-0.004048394,-0.11494224,-0.07899193,-0.021913005,-0.01952717,0.21846534,0.04301203 +4.2.3.219,A sesterterpenoid synthase enzyme isolated from the fungus Aspergillus stellatus.,384,0.99999994,-0.038044583,-0.0056350203,-0.115056485,0.0487361,0.0031964313,0.02299033,-0.14237162,0.026154097,0.05182863,-0.063187875,0.033717047,-0.0481509,-0.0011226793,-0.041820865,-0.09183746,0.026784062,0.023664836,0.024381084,0.06219147,-0.05997749,0.023599379,0.06876625,0.016880052,0.047672953,0.098517805,-0.029673545,0.052552,-0.050946508,-0.045661014,-0.101251796,-0.04787253,-0.04816707,0.059665833,-0.030738775,0.059605915,0.0071400288,-0.049850173,0.013448345,0.08240849,0.06667954,0.038475573,-0.050652187,0.0044405563,-0.08450746,-0.097151674,-0.020990983,-0.03246386,0.0083986195,0.039113745,0.03405104,-0.056800865,-0.05427288,-0.028801704,-0.044622127,0.029896248,0.019353196,0.06406223,-0.07099551,-0.030534348,0.06700193,0.051900025,0.06012669,-0.005057438,-0.042546693,-0.052667566,-0.025949474,0.008486956,0.004994833,-0.044348523,-0.05840383,-0.08448389,-0.06885896,-0.027911453,-0.0049666027,-0.019067481,0.0055905534,-0.0096530225,-0.024911508,0.06593979,0.030824866,0.06628221,-0.0062254225,-0.0043346956,0.018479401,0.020347523,0.04027408,0.044122584,0.045204785,0.034376506,0.0221197,0.028660858,0.020578368,-0.02639439,-0.00893938,-0.0017191636,0.09311034,0.03335106,0.09032068,0.031475805,-0.04703876,0.01864926,-0.02775252,0.026475187,-0.038854826,0.0014050284,0.0041670473,-0.000826652,0.0048944075,0.052925553,-0.048408277,0.05183053,-0.032505274,-0.02055145,-0.041113883,0.04389778,0.0048514283,0.039174188,-0.0030834505,-0.032744568,0.038244005,0.037674345,0.049653426,-0.007558955,0.042607404,0.036697097,0.05565639,-0.036572024,4.295182e-34,0.06407866,0.109787695,-0.025559051,0.012297883,-0.027887076,0.005894854,0.023322819,0.086833596,-0.09323145,-0.08931984,-0.07256205,-0.07221411,-0.045359023,0.068393655,0.077554844,-0.034937996,0.07051589,-0.0055982326,0.028062744,-0.04531239,0.0414617,-0.0074704145,-0.078121096,-0.019642219,0.00871565,0.020672373,0.012161071,-0.02669941,0.08205591,-0.06933176,0.008720586,-0.008134619,-0.054679576,0.008262089,0.10466813,-0.04928177,0.029721638,0.010920407,-0.113390826,0.0032259817,-0.033168647,0.045130897,-0.017313529,-0.074875794,0.033175558,-0.022431532,-0.05530352,0.010965808,0.12063923,-0.0056335405,-0.001300753,0.061300684,0.108505294,0.017342139,-0.0007910834,0.017358102,-0.044094212,0.0014709228,-0.0021859885,0.04294439,-0.030646015,0.047408793,-0.047635484,-0.010081794,-0.004484369,0.04566837,-0.04070757,-0.058195654,0.0015214493,0.018898346,-0.015853077,-0.029513326,-0.023263646,-0.04479415,0.034231476,-0.013953044,-0.14579833,0.020777546,0.0026416488,-0.07778509,0.00077951135,0.0035138635,0.027238313,-0.032071598,-0.06897047,-0.0550112,-0.0020867665,0.046384476,0.034307715,0.056649502,-0.008422469,-0.090926245,-0.05817806,0.06920546,0.015112724,-1.4872133e-33,0.09199484,-0.13385591,0.033004824,-0.017959494,-0.070715524,0.07922183,-0.004097261,0.027709763,-0.054871134,0.00861023,0.012709298,0.027135171,0.085747674,-0.034384485,0.011529155,-0.0114807,-9.739005e-05,0.12306678,0.019421339,-0.038599364,0.03953374,0.08072815,0.013418491,0.07910894,0.036800604,-0.0065885833,0.04783217,0.025069995,-0.053369492,0.062346734,0.026051864,0.0077760387,0.031026086,0.010807021,-0.113747746,0.13615517,-0.0068477388,0.0015410566,-0.015083529,0.06476363,-0.026662799,0.0049998364,-0.0002683747,0.08674348,0.08153661,-0.015929969,-0.059357654,0.051500894,-0.01135333,-0.048971377,0.01890371,-0.019169455,0.010998707,-0.06620162,-0.01768723,-0.022017827,0.008175266,-0.03820581,0.03692058,-0.08295309,-0.043822065,-0.02104041,-0.051636923,0.014438907,0.03651965,0.026491037,-0.033189964,0.0014945553,0.07258383,-0.026462298,0.051584695,0.07214403,-0.020630457,0.065213434,0.05989376,-0.051380374,0.011829632,-0.03872448,0.0029995188,0.03398137,-0.013268968,-0.043767374,0.08392343,-0.055983454,-0.089745015,-0.092544295,0.09737614,0.05173531,-0.072397985,0.05270555,0.0038209443,0.026239673,-0.10267837,0.075036556,0.08028289,-1.9373633e-08,0.07666493,0.050310012,0.038048692,-0.0627815,0.009811765,-0.037777994,0.09879947,-0.048011757,0.06614208,0.021619888,-0.10130364,0.004361321,0.024491558,0.059208464,0.07503386,-0.018369095,0.013247095,0.0040205102,0.006969676,0.051804468,0.04063326,0.018876743,-0.09419322,0.017701706,0.00037710342,-0.09215173,0.016627884,0.045080267,0.039440967,0.05759771,-0.003168702,0.036634997,0.005122873,-0.03805303,-0.041720755,-0.014625392,0.008123242,-0.0838201,0.017004544,0.019866537,-0.013592122,-0.074294604,-0.05672818,-0.03296484,-0.07569512,-0.04644223,-0.007386155,-0.0880971,0.004736292,-0.010648739,0.05310866,-0.021731835,0.006508529,-0.042811494,-0.03817945,-0.035847485,0.0166905,-0.014156412,-0.089034714,-0.07699288,-0.025810909,-0.034122977,0.18964413,0.016372086 +6.7.1.2,"The enzyme, characterized from the bacterium Streptomyces sp. RI-77, participates in the biosynthesis of avenalumate, a phenolic acid originally described from oat (Avena sativa). It can also act on 3-aminocoumarate and 3-amino-4-hydroxybenzoate with lower activity.",384,1.0,-0.023880247,-0.04916504,-0.17729808,-0.0057694064,0.023001805,0.10001026,-0.05484129,0.071864285,0.06755447,-0.023102725,-0.036306314,0.015494193,-0.10434856,0.009623254,-0.052459523,0.028396606,-0.027221601,0.018862197,0.03645404,-0.05925113,0.06731807,0.048220135,0.017167382,-0.04487007,0.08849343,0.024732258,0.018670684,-0.004829394,0.005562397,-0.065128,0.024730872,-0.039923724,0.06777053,-0.050714727,0.035732903,0.030295089,-0.035195526,-0.08626914,0.0035205148,0.024014538,0.010104884,-0.015748331,-0.03334189,0.025490975,-0.08488198,-0.072057076,0.040310275,0.06040949,0.0072336635,-0.056083683,-0.07104181,-0.026520066,-0.08340123,0.044938132,-0.019968692,0.035947513,-0.013305675,-0.039645907,-0.03702359,0.026614977,0.04883785,-0.0032252318,0.044670913,0.0040671146,-0.055841073,-0.028472202,0.017627686,-0.06375334,0.045586985,-0.07372732,-0.06471339,-0.06195416,-0.004884307,0.02926794,0.017152952,0.03531866,-0.029157978,0.027591843,-0.016236182,-0.017994832,0.04513884,0.016282365,-0.033962835,0.11897681,0.04366255,-0.013843133,-0.0003387744,0.035825476,0.109472245,0.011240189,0.059490662,-0.03609069,0.00024899837,-0.030783543,-0.028789708,0.058439616,0.0009713415,-0.051025074,0.007180294,0.005226756,-0.007984154,0.08703253,-0.013140704,-0.00780033,-0.04815976,0.030645156,-0.07331714,0.053999715,0.011590603,-0.022320675,-0.011138242,0.0067581907,-0.010444568,0.013806737,-0.045592245,0.031974953,0.040124554,-0.105972014,-0.046723455,-0.021509841,-0.021825006,-0.02353286,0.03517401,0.07142681,0.051603854,0.040519465,-0.12016127,8.132352e-34,0.0671125,-0.0062358966,0.06112309,-0.098871484,0.025721971,0.047663573,-0.08705184,0.022970997,0.027239103,-0.055773627,-0.06303121,-0.088449046,0.00894383,0.060880147,0.06125923,0.0043680063,-0.03832354,-0.01867581,0.070712216,0.008233322,0.012770128,0.060836256,-0.11581623,0.04323795,-0.009009393,0.07715094,0.017583689,0.014972755,0.047301654,-0.009697401,-0.017643917,-0.070430905,-0.10177204,0.03949949,0.06142281,-0.032144643,-0.10250129,-0.07346463,0.047106203,0.088501625,0.019475905,0.0063705365,0.029770954,0.0062588723,0.06496053,-0.06320333,-0.0069807786,0.10809007,0.08072499,0.07184179,0.014768767,-0.0044593397,0.07596381,0.052794617,-0.10339463,0.010434865,-0.061381314,0.05568727,0.06779161,-0.010291468,-0.039496623,0.000529673,0.026052995,0.049483355,-0.016842665,-0.011078178,-0.050118424,-0.04966993,-0.004302597,0.07774585,-0.040567335,-0.042105913,0.01608321,-0.019384138,0.0085006,-0.027015783,-0.05687905,0.020539377,0.07639944,-0.01090707,0.00012511865,-0.034644473,0.00026675893,-0.0011345114,-0.08956493,0.01836199,-0.029045068,-0.052597888,-0.005003705,0.04008549,0.025035635,-0.042018343,-0.10052209,0.099252105,0.0011916189,-2.1193023e-33,0.11650677,-0.11893005,0.079332754,-0.014673092,-0.01914688,0.026835315,-0.050052598,0.020425081,-0.063327484,-0.027554994,0.064957924,-0.032207333,0.049296435,-0.07433147,0.031823423,-0.007773112,0.043093037,0.07154769,-0.012305974,0.05539213,-0.04351941,0.053083334,0.060292944,-0.018050902,0.05279629,-0.015442934,0.091885485,-0.044311505,-0.022074262,0.039015878,0.043459617,-0.0018768685,-0.028864471,-0.055285413,-0.032697096,0.03799112,-0.009163744,-0.0004216639,0.031024734,0.009822772,0.07381631,0.019705217,0.049424313,0.037358586,0.057741474,0.06654176,-0.09931106,0.025977468,0.003865911,-0.10398878,0.038002416,0.030383207,0.06581912,0.02455447,0.06174155,-0.0045224633,-0.0038982483,-0.09184966,-0.0029459607,-0.001674601,-0.0058988323,-0.042856004,0.012704531,-0.019575609,0.083152145,0.008771703,-0.044546884,0.068842694,0.014470573,-0.014133392,0.07064528,-0.03096777,-0.016328324,0.10787832,-0.005371326,-0.058746148,-0.028510658,-0.038906284,-0.00057483424,-0.0066595622,-0.021427892,-0.04240805,0.026939701,-0.0882498,-0.0945894,-0.062746935,0.0037404906,0.1255122,0.029237716,0.1300264,-0.015965011,0.033975188,-0.0728115,0.0335502,0.0964532,-3.863085e-08,0.01745073,-0.089673124,0.072347604,-0.013265185,0.013152876,-0.070330985,0.020034235,0.012069766,0.024469944,0.012197951,-0.034728177,0.00045444202,0.020614732,0.025783192,0.019244192,0.022139331,-0.01613031,0.0022290198,-0.01796554,0.032491345,-0.07035336,-0.029538631,-0.05600666,-0.018531803,0.01164783,-0.07103162,0.017576981,0.052939393,0.022382291,0.009698281,-0.0069655376,0.0012874748,0.050143413,-0.022634523,-0.14048736,0.0020606613,0.07769243,-0.13319169,0.0077861673,-0.054617006,0.0081450185,-0.00022787144,-0.02358791,0.0032599224,-0.0070529357,0.0074509108,-0.015727185,0.00050415716,-0.021151064,-0.06554361,0.0414446,0.0174306,-0.013335803,-0.037490126,-0.104269564,-0.022402314,-0.021811996,-0.052548923,-0.017072782,-0.047227517,0.050807938,0.0065687452,0.16279425,-0.0022361528 +1.1.1.438,"The enzyme from Corynebacterium cyclohexanicum is highly specific for the cis-4-hydroxy derivative. cf. EC 1.1.1.226, trans-4-hydroxycyclohexanecarboxylate dehydrogenase.",384,1.0,-0.04043324,-0.02249317,-0.053174797,-0.015318916,-0.044039488,-0.007919835,-0.08200374,0.060813736,0.029528573,-0.049182504,0.03470745,-0.065136425,-0.022563899,0.007400997,-0.020742567,0.046974976,-0.0031318476,0.052755408,-0.027404217,-0.056504667,0.011235389,0.025236657,-0.007677281,0.042596787,-0.0047975183,-0.038081937,0.048938192,0.03505984,-0.023646528,-0.003465282,0.076246664,-0.008671,-0.023603827,-0.033030283,0.08044271,0.044459615,-0.044461306,-0.12325727,0.17149033,0.023955716,0.0586397,0.06633387,0.008639542,0.02205731,-0.07811827,0.028643295,-0.011781852,-0.001977048,0.051345564,-0.03330092,0.055488396,-0.06993509,-0.07494865,0.035756916,0.042746227,-0.001184983,-0.06944027,-0.032374784,0.047773678,0.085587725,0.03655608,-0.018589377,0.035092536,0.03242465,-0.0126274275,0.0044236975,-0.02030715,-0.067356326,0.03360939,-0.086312935,-0.11057938,-0.0378184,0.03495549,0.09194925,-0.060162153,0.021705516,-0.04667663,-0.045401786,0.0130057195,-0.084658295,0.03466991,0.025702614,0.019735008,-0.0057441765,0.03740218,-0.040210444,0.07756921,-0.028581316,0.02585773,0.038953245,0.08023607,0.0060634958,0.009498773,-0.07525381,-0.021775214,0.023953516,0.037518322,0.014643499,0.03372403,-0.005530174,0.013899955,0.05110394,-0.079194,-0.062261395,-0.07027131,-0.022497918,0.027084857,0.06921655,-0.0059480327,0.050904557,-0.06280728,-0.057220705,0.00859868,-0.042728145,-0.029615212,0.023840968,0.047895692,-0.032069683,-0.0123045845,0.010252963,-0.0127285095,-0.056864712,0.056728378,0.025222005,-0.024417153,0.09003407,-0.06342553,2.0662711e-33,0.014971356,0.025978364,0.050621513,-0.0061296737,0.06663014,-0.06125452,-0.0119578475,0.0034188312,-0.07513111,-0.053156957,-0.122097366,0.0040174737,0.019171497,-0.06574439,-0.082154244,0.0120261265,-0.03497289,0.010515776,0.04114554,0.091067806,0.036172986,-0.022832002,-0.009270837,0.062172603,-0.06961331,0.043507013,0.012323825,0.03030983,0.10077072,0.011395016,-0.12582792,-0.11533993,-0.08400682,-0.053705867,0.053063877,-0.013579437,-0.02839965,-0.049440384,0.01900456,0.10095145,-0.013193315,-0.037095983,0.022230662,-0.07048183,0.06281484,0.03749596,-0.043288104,0.05795593,-0.028339537,-0.008590705,-0.015513171,0.0012031264,0.030304959,-0.067992456,-0.050503783,-0.0307094,-0.0260842,0.067966364,0.056227896,0.04655123,-0.019878445,0.101583704,-0.065674625,-0.0050025955,0.038015377,0.0023629128,-0.080755554,-0.021621952,-0.03837294,0.053245652,-0.045441326,-0.03667538,0.075296566,-0.027117632,0.071171075,0.0037236658,-0.118298,0.0054284716,0.011882654,0.009046407,-0.084889226,0.036387097,0.039099153,-0.02493288,-0.030861698,-0.0713277,-0.0217813,0.05269877,-0.02864248,0.050284047,0.05647297,-0.087460935,-0.03276289,0.065427326,0.022053633,-3.4195472e-33,0.09866789,-0.013189671,0.0022293867,-0.0963312,0.04039227,0.06698572,0.037659142,-0.046301045,0.05058478,0.048862193,0.17576768,0.026019596,-0.028347807,-0.029270623,-0.01555391,0.014509494,-0.03003645,0.053252943,-0.05335292,0.0070241727,0.02310844,0.044858657,0.012208415,0.052926227,0.012240684,-0.0025909462,0.05338606,0.10111912,0.035611745,0.0919133,-0.052429546,0.030884136,-0.0010994483,0.022696042,-0.08699301,0.061392326,-0.048438493,-0.024173403,0.016275097,0.040673204,-0.0150428545,-0.0057082074,-0.018401153,0.096310586,0.017286677,0.020155312,-0.04252577,0.017359197,0.04463655,0.028921532,-0.012679641,-0.016091961,0.0031682819,-0.015722562,-0.0530069,0.05835851,-0.018551813,0.0094360495,-0.021129394,0.005663908,-0.059064683,-0.06962239,0.08500005,0.017259043,-0.029050132,0.07224683,-0.052972376,-0.005074987,0.06472891,-0.03315451,0.034730535,-0.013025063,-0.062445156,-0.030278714,-0.04304459,0.031281415,0.04382332,-0.036719985,-0.07664259,0.01985774,-0.011195404,-0.018650109,-0.04102249,-0.01270684,0.025910575,-0.046836972,-0.022638042,0.10422296,-0.0027526987,0.006439419,-0.020378944,-0.017106585,-0.07324876,0.017599244,0.038336914,-3.2746687e-08,-0.05724073,-0.033541825,0.034087677,-0.0044054,0.07470011,0.061667982,-0.03231432,-0.01021993,0.051121984,-0.08420985,0.039592765,0.01499609,-0.032835234,0.03702582,0.06919706,0.049793288,-0.062938206,0.01699228,0.008587691,0.008044721,-0.05107678,-0.06001405,-0.024339873,0.02871549,-0.034065034,-0.04712799,0.06946745,0.00017188898,-0.039327078,0.017096126,0.049873203,0.009449412,-0.07254723,-0.0020803912,-0.008142383,0.013964067,-0.028605958,0.029288191,-0.036308177,0.056711283,0.014884811,-0.030609068,-0.12582867,0.034298755,0.04200223,0.054937378,-0.036738615,0.049834143,-0.014762355,0.043166637,0.024279227,-0.026545994,-0.06694279,0.019504601,-0.008120296,0.024869373,-0.046179216,-0.07259964,-0.1174183,-0.058016475,0.02489931,-0.0027461988,0.25675282,-0.005871018 +1.5.1.55,"The enzyme, characterized from the cyanobacterium Synechocystis sp. PCC 6803, catalyses the reductive condensation of agmatine and L-aspartate 4-semialdehyde. It participates in a biosynthetic pathway for spermidine.",384,0.99999994,-0.09005597,-0.03244375,-0.10949778,0.020039465,0.0357184,0.09380918,-0.06771203,0.08200024,0.021622567,0.019391123,-0.020731127,-0.0087770065,-0.10262959,0.008184369,-0.08462871,0.073969,-0.057888404,0.0057991473,-0.020157717,0.018660318,0.038061094,-0.0021601715,-0.043543734,-0.007296248,0.09566896,0.008987426,-0.004112691,0.040315036,-0.056246445,0.037064012,-0.013524238,0.0065880273,0.042812448,-0.017147716,0.14978991,0.032697123,-0.07625006,-0.04030845,0.06406519,-0.0257576,0.09619747,-0.031788763,-0.018760702,0.042677693,-0.0069262283,0.09226009,0.05091226,0.020050347,0.054427087,-0.06943974,-0.004922025,-0.004718946,-0.041065387,0.0068786587,-0.009932911,-0.012572819,-0.06404219,-0.115524866,0.012989144,0.053279262,0.00987288,0.023205472,-0.070428945,-0.00018936387,0.1065082,-0.07298074,-0.031585015,-0.0061840564,0.040080875,0.02144782,-0.032207254,-0.03830621,0.021996668,0.06941717,0.015486245,0.0077139377,-0.009266898,0.0038773047,0.03546599,-0.07098469,0.04670411,-0.014218778,-0.0028499078,0.04508922,-0.009045767,-0.038731545,0.080596805,0.01992526,0.021675473,0.019271303,0.010987225,0.013201672,0.017582985,-0.13892515,-0.077727996,0.038500205,0.05487231,-0.004679873,0.04211936,0.029795883,-0.017069478,0.07424143,0.019520933,-0.12371081,-0.031821262,0.0034330294,-0.032968994,0.12214005,0.07659805,-0.008754005,-0.036502454,-0.024600994,-0.025333732,-0.003800136,-0.027097395,0.022972658,0.030288426,-0.014164845,-0.048150536,0.017032053,0.0036943264,-0.07303898,0.025479812,0.05854783,0.023971874,-0.0020042812,-0.098250866,2.546686e-33,0.09470279,-0.026635643,0.04059353,-0.025015261,0.023210367,0.024610655,-0.044301685,-0.08264433,0.0051358035,-0.03461481,-0.07204655,-0.101865865,0.028896756,0.008465921,-0.09660136,-0.03316962,-0.06607991,-0.0122280745,0.028157864,0.037865344,0.051599625,0.0625335,0.0024315377,0.0394581,-0.024195164,-0.017003303,-0.07087525,0.012575316,0.06041521,-0.022262042,0.022332694,0.0029414163,-0.112516254,0.012722228,0.07731303,-0.039366014,-0.07886858,-0.12207076,0.054426424,0.078048125,-0.06360887,0.0034495315,0.028783409,-0.018720096,-0.009441245,-0.0055418666,-0.025213614,0.08420406,0.05578883,0.029621283,0.041674387,-0.050621983,0.10347414,0.005415338,-0.03051825,0.0136209605,-0.055259977,0.013629983,0.023216406,-0.012944717,0.07174008,0.00021072224,-0.06581819,0.030998,-0.00059250696,-0.0026111247,-0.08103288,0.039288864,0.034242418,0.05286297,-0.07857047,-0.022437066,0.04898479,0.035406552,0.026304714,-0.027438805,-0.072812386,0.006838712,-0.03405918,-0.043952826,-0.041497253,-0.015885035,-0.036878787,0.028438866,-0.06537068,-0.0024246024,-0.050767936,-0.029073775,-0.009146027,-0.021375883,-0.009195631,-0.108274974,-0.045589633,-0.0077840863,0.013457209,-3.9795924e-33,0.09541703,-0.10411329,0.011514877,0.021484049,0.0020158605,0.025428489,0.054960605,-0.022193648,-0.046649244,0.026843438,0.10103059,0.025987124,0.11558448,-0.0166024,-0.013343558,0.011480706,0.038158234,0.09850794,0.013640061,-0.0067104497,-0.03763401,0.056767687,0.01931558,-0.024321793,0.071207836,-0.06685543,-0.0412061,0.05620597,0.048560865,0.03801465,-0.021504615,0.08268132,-0.042143878,-0.024253761,0.009446855,0.015226684,-0.002515598,-0.054529544,0.020129576,0.028015928,0.03663952,-0.01508867,-0.033734206,0.11349405,0.07753586,-0.0003687604,-0.07063739,0.10468418,0.026277144,-0.025241531,0.04519756,-0.03276003,-0.016083349,-0.006803303,0.016133107,0.029283242,0.07502655,-0.07538116,0.019922027,0.015493347,-0.07071065,-0.09109484,0.029549198,-0.0047614323,0.049107462,0.054104555,-0.019561704,0.14832205,0.019108044,-0.0399689,0.0996446,-0.000919789,0.045592126,0.030271418,-0.009696573,-0.071079545,0.0005088429,-0.030695442,0.008635754,-0.019058723,-0.029552614,-0.037353516,-0.0026565958,-0.013075273,-0.052237265,0.0002513099,0.08771577,0.12299718,-0.11781373,-0.0010800787,-0.001784785,-0.02482076,0.066147335,0.13936435,0.03329826,-3.6259284e-08,0.044484083,-0.0068692598,0.055480983,-0.07585771,0.026891707,0.051670764,0.03114247,0.0014626898,-0.012245439,-0.06181724,-0.016929077,0.011503939,0.011103591,-0.040973343,0.090394445,0.007924213,-0.01000384,0.017940424,-0.059980594,0.017604731,-0.02695708,-0.056064535,-0.14727227,0.047991663,-0.033798378,-0.011046173,0.024744159,0.039572775,-0.031890158,-0.047929894,0.05575493,0.01796908,-0.037926562,-0.02280736,-0.066913195,0.06435312,-0.060371045,-0.082885996,0.047854092,-0.017093023,-0.031007724,0.021184845,-0.07193714,0.0013801971,-0.032874998,0.021652069,-0.023641298,0.024819849,-0.08234388,0.031171473,0.005276978,0.01315845,-0.06566567,-0.01746771,0.014082008,-0.005432549,0.012521718,-0.03379507,-0.030875083,-0.011280937,-0.006392806,0.025598383,0.12640025,-0.038153686 +1.14.13.252,"Contains FAD. The enzyme, characterized from multiple bacterial species, participates in the biosynthesis of assorted siderophores.",384,1.0,-0.06675267,-0.10083401,-0.09017297,-0.05342769,0.11178154,-0.0015045085,-0.040368434,0.03355829,0.02748028,0.0077878004,0.042265974,-0.06108814,-0.06495012,0.021359308,-0.021865115,-0.008980049,-0.09182289,-0.032123946,-0.02667274,-0.023511283,0.02258202,0.075923085,-0.022358218,-0.005102022,-0.020402558,0.018743232,0.056569666,-0.02727375,-0.026885455,-0.0141769685,0.017528988,0.026033422,0.011333874,-0.03993478,0.048625123,0.0856942,0.014553674,-0.035368335,0.097856864,0.003424668,-0.015790325,-0.03996594,0.061120898,-0.034238648,0.018401526,0.030082472,-0.004617927,0.01458198,0.03199993,-0.007087413,-0.017349469,-0.017035427,-0.07534073,0.049477983,0.007706348,0.043457653,-0.017585333,-0.06332862,-0.042829644,0.0415098,-0.017076446,-0.04272632,0.033833865,0.011950319,0.020042097,-0.07105441,-0.027905859,-0.061764345,0.0044968333,-0.025142232,-0.010894976,-0.081465974,-0.021563811,0.021952946,0.032865755,0.043246485,0.005837385,-0.023815205,0.039097127,-0.06412458,0.05122681,-0.008726343,0.08256799,0.12591302,0.05104444,-0.05607655,0.0654131,0.015070517,-0.030733094,0.049877476,-0.0007836783,-0.046083886,-0.00028315492,-0.11141427,-0.069609396,0.046089817,-0.023640731,-0.014668507,0.0026318587,-0.06128945,-0.072600104,0.026130613,0.049777247,-0.05282214,-0.07345537,-0.07149292,-0.02890116,0.13256918,0.013626795,-0.027623514,-0.0023266973,0.06397512,0.010806186,-0.02253092,-0.0044155885,0.00588365,0.04065611,-0.080564685,-0.038180195,0.000987278,-0.029398419,0.0023886072,0.07327957,0.11586662,0.02730947,-0.011055992,-0.122894615,-8.622819e-34,0.039970353,-0.020626117,-0.030481791,-0.07606698,-0.031306505,-0.0066160937,-0.08724696,0.011407138,-0.00108376,-0.006690191,-0.030675441,-0.03630143,0.0012583926,0.012594423,0.019752378,-0.01737948,-0.046572004,-0.041254025,0.05309808,-0.083640695,0.030488247,0.11128181,-0.02358319,-0.0059920363,0.03475512,-0.036677048,-0.040307537,0.05703914,0.028923653,-0.0069522546,0.020043531,-0.111183725,-0.05195323,-0.02286651,0.06322655,0.05548654,-0.024658715,-0.0715249,-0.05440613,0.035864763,0.028923014,0.031257987,0.021802487,-0.019338222,0.04042315,-0.03557964,-0.06415426,0.07380009,0.062962584,0.056144334,0.027141565,-0.01013685,0.1300418,-0.0115824295,-0.05950171,0.0055617886,-0.08373123,-0.003998704,0.027652532,0.033168323,0.0046318164,0.043304425,-0.06047357,0.07729513,-0.039946366,0.024282297,0.04522373,-0.052766014,0.026876546,0.10385123,-0.034978952,-0.030862967,0.08951536,-0.024950944,0.05056121,-0.06928112,-0.028964672,-0.012633024,0.062503114,0.0048348242,-0.026213603,-0.045562368,-0.02149658,-0.019151423,-0.043992378,0.019483594,-0.05916781,-0.07097894,0.018745286,-0.044132516,0.05471873,-0.08511114,-0.06266761,0.0524618,0.0018458435,-1.4812548e-33,0.01494434,-0.14076419,0.082607776,-0.05554549,-0.02899594,0.106190115,0.03501886,0.003615486,0.02254934,-0.024810798,0.046101574,-0.0061387443,-0.063553825,-0.071315765,-0.014994639,0.02663307,-0.04462866,0.040173862,0.08007587,0.05170434,-0.0368795,0.06914679,0.09552349,0.04658612,0.07503856,0.05596704,-0.022698965,0.07157647,0.04050651,0.02658766,0.0034559632,-0.0049971854,-0.037309304,-0.067562245,-0.10555422,-0.0153589975,-0.021765556,0.01924876,0.0057080677,-0.0059783743,0.03991641,0.004845749,-0.0012599101,0.11067438,0.004404737,0.060118698,-0.08183585,0.10004817,0.019007169,-0.0988073,-0.018827403,0.012156437,0.039112687,-0.032921836,0.05262831,0.024873111,0.024806438,0.06313647,-0.045706283,0.0071932506,0.001717065,-0.08586056,0.03435621,-0.0014725596,0.08546738,0.075435705,-0.01837123,0.030844659,-0.0051961755,0.031438004,0.07596091,0.044743747,-0.025436915,0.041006308,0.015349498,0.0054306486,-0.071271986,-0.05668365,0.04163885,0.081464104,0.028337836,0.025306165,-0.071225144,0.024473641,-0.08502658,-0.1019632,0.03171397,0.08654504,-0.014852575,-0.003703504,-0.0066020847,0.048378028,0.026595354,0.022285813,0.09254269,-2.7855805e-08,0.059255164,-0.0663237,0.056634884,-0.0899027,0.03128385,0.040103544,-0.028267613,-0.022802126,0.0046279985,-0.02750326,-0.06473921,0.091857545,-0.03401162,-0.020532446,0.049391676,0.003920583,-0.059394035,0.0008860205,-0.038892664,-6.756263e-06,-0.06301006,0.015999269,-0.09033138,0.008159333,-0.0095999325,-0.004706833,0.014641931,0.0012987861,-0.045713425,0.0011398591,-0.0008047799,-0.022657929,-0.008580256,-0.014929424,-0.08729047,0.054732986,-0.010153506,-0.08478848,-0.06109731,0.045108143,-0.0026210828,0.022117462,-0.07022585,-0.011693373,0.014239474,0.03981623,0.0082091475,0.028598791,-0.05070068,-0.01659581,0.023437666,-0.04527974,0.03215021,-0.028439224,-0.13121432,0.0029143516,-0.032505956,-0.10664908,0.026361784,0.0047953934,0.048027847,0.06737825,0.20236519,0.048420794 +1.14.14.185,The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew).,384,0.99999994,0.026999494,-0.037280414,-0.08737736,-0.02380763,-0.006880582,0.035346534,0.0022758502,0.016969893,0.06169355,0.033253826,0.023705494,0.027522009,-0.05725938,-0.011539202,-0.005478382,0.020733038,-0.050969563,-0.008620919,-0.0084521165,-0.0073786597,0.16442992,0.009689063,0.081201516,0.063977085,-0.05847025,-0.070030995,-0.041582383,0.013904367,-0.012740418,-0.08491651,0.026483983,0.008148715,-0.031934593,-0.012427247,0.033054035,0.03696193,-0.02467943,-0.0020834822,0.056466646,0.050645437,0.04219796,-0.06251721,-0.10787404,-0.024139531,-0.0979479,-0.08343627,-0.022648629,-0.050862234,0.10400316,0.08768316,-0.06526235,-0.073277704,-0.05428387,0.015111473,0.009783874,-0.0046300367,-0.022036927,-0.024865225,-0.014998975,-0.046106953,-0.018655697,0.020362493,0.0035269256,0.02420227,-0.021779208,0.038305152,-0.037303954,-0.019089833,0.0057645305,-0.08647316,-0.057969116,-0.0706051,0.03677106,0.04084559,-0.06807526,0.010158394,0.043098215,0.071330786,0.060150087,-0.096732125,0.04163757,0.05795205,0.024863448,0.10624089,0.037698362,0.014049579,0.07740755,-0.0066916337,0.10641366,0.008894337,0.03694647,0.029859506,-0.02065164,-0.0010725611,-0.021676287,-0.03393242,0.06253629,-0.045741223,-0.0026763438,-0.011377853,0.02149432,-0.0059223063,0.0034860012,-0.14659198,-0.06967752,0.05926153,-0.11352372,0.05429858,0.015965618,-0.03484564,-0.0074893115,0.030286476,0.016803553,0.08093409,-0.00094507507,0.11715449,-0.050187413,-0.096504495,-0.0820737,-0.091171496,-0.030344492,-0.07737287,0.02713573,-0.017700823,0.009812989,0.015731875,-0.01598847,-3.214374e-33,0.04387508,0.00058664416,-0.011606563,-0.072680674,0.042224515,-0.0338712,-0.015756954,0.047360435,-0.1340501,-0.012526832,-0.08667987,-0.07055259,-0.043369908,0.027289044,0.027667942,0.015802221,-0.014389837,0.018095013,-0.0017672554,-0.017868733,0.015838556,0.07435636,-0.0038991566,-0.038335845,-0.05709889,0.09934669,-0.041089263,-0.015000219,-0.005151052,0.0031043098,-0.0070910035,-0.11136282,-0.025562506,0.033397123,0.018590996,0.067117356,-0.0035123827,-0.039717305,-0.013960338,0.029441046,0.03969226,0.025683608,0.083243795,-0.054032397,0.0015046025,-0.030138515,-0.01992324,0.02401422,0.0774335,0.043219734,0.009579716,0.01957249,0.07871263,0.0034996576,-0.080771394,0.055934638,-0.04690406,0.022989662,-0.012453341,-0.0047129346,0.042059805,-0.014318905,-0.011138845,0.038449965,0.0032907946,0.052453425,-0.072805874,-0.00864497,0.033009157,0.10598759,-0.07761935,0.011900483,-0.0008060777,-0.005488353,0.06515148,-0.024242757,-0.0093976,-0.010160069,-0.02937559,0.06632798,-0.032451626,0.0029625678,-0.05142094,0.06256732,-0.049207326,-0.021987427,0.025597122,0.048312765,-0.057569113,0.005369382,0.044858072,-0.06643614,0.0017810431,0.03947288,0.012750168,2.3836006e-34,0.07395594,-0.0969779,0.07789289,-0.04314858,-0.05209646,0.12558767,0.019795047,-0.019751025,-0.01652851,0.0355629,0.027974077,0.06720682,0.04322896,-0.032345243,-0.03821582,-0.027214829,0.051393606,0.047315244,-0.05062408,-0.048583556,0.0022063206,0.12728536,0.017692858,0.061201435,-0.025755702,-0.007744138,0.057085793,0.082587436,-0.033545252,0.022289883,0.047333945,0.05173717,-0.050187923,-0.017901467,0.0015419701,0.019695442,-0.030265857,-0.05065158,0.007484653,0.041970603,-0.042652268,0.0065650055,0.012461409,-0.012135565,0.043869704,0.0017738241,-0.1058473,-0.0033501394,-0.05446482,0.038879093,0.06357606,0.04214838,-0.00077613816,-0.0019606354,0.008629563,0.06486313,-0.035589814,-0.015142196,-0.0051987562,-0.02463285,-0.07678065,-0.0057607414,0.006005221,0.017200736,-0.010719421,0.022562992,0.010267795,-0.031579185,0.09493555,0.0057596886,0.06283198,0.057586662,-0.06800301,0.081774816,-0.0049219783,0.019178974,-0.023499325,-0.07573057,0.027974224,-0.0206289,0.03495533,-0.011471544,0.038514696,-0.11097902,-0.044351436,-0.0073159155,0.0054568443,0.09752791,0.054241493,-0.00384668,0.033043742,-0.100065984,-0.030929597,-0.021912348,0.02687861,-2.4628875e-08,-0.00968599,0.014847213,0.02472421,0.031317692,-0.05715266,-0.012830492,-0.011506026,0.013292903,-0.015205916,-0.07584168,0.06358011,0.05173933,-0.011331784,0.050727718,-0.00077228463,0.010693291,0.025089273,0.079814136,-0.045123223,-0.039581403,-0.08912538,-0.049377125,-0.09364802,0.08954568,0.023069445,-0.08557312,0.025082545,0.042638626,0.024432357,0.0060398974,0.0002686705,0.009588582,-0.057955973,-0.038008336,-0.056203526,0.06366681,-0.0046292823,-0.015290032,0.048514124,0.06760596,0.07366895,-0.07867468,-0.035500538,-0.041755214,-0.042639505,0.03793783,0.027607223,-0.056383543,-0.00061774283,-0.012213888,0.044897653,0.010966554,-0.02476742,-0.09217088,-0.15224548,-0.011476004,-0.042556558,-0.06709309,-0.02241028,-0.102734774,0.07597615,-0.015203583,0.1981501,-0.03899879 +1.17.3.5,"Contains FAD. The enzyme, characterized from the bacterium Corynebacterium cyclohexanicum, participates in a cyclohexane-1-carboxylate degradation pathway.",384,0.99999994,-0.051379934,-0.039568983,-0.05409226,-0.020277457,0.07542275,0.013900885,-0.046699457,0.034747478,0.037634563,-0.017754937,-0.014617909,-0.042366225,-0.03742873,0.02717803,-0.070256576,0.024204368,-0.09335278,0.009385363,-0.022389486,-0.034080442,0.0335835,0.078258395,-0.0019404847,0.031099679,0.03850891,-0.030404216,-0.0036187128,-0.026368938,-0.0043813046,-0.001958247,0.03981926,0.022276718,0.055577017,0.013268121,0.1094954,0.07688666,0.008599509,-0.068202056,0.10468186,-0.02768721,-0.045048907,0.05743217,0.039807096,-0.0063771955,0.000855843,0.086386606,-0.009598115,0.0023912112,0.026097648,-0.042033397,0.042447556,-0.048143245,-0.048651945,0.046306383,0.06344551,0.07371306,-0.050617095,-0.066277295,0.006429623,0.03334747,0.02520558,-0.0017063994,0.021275716,0.043531712,0.0033723388,-6.108559e-05,-0.043147545,-0.04724559,0.02704294,-0.03876572,-0.06863131,-0.077872865,-0.009315004,0.040001456,0.008726321,0.029064832,-0.06633455,-0.099095255,0.01070472,-0.027789367,0.04479145,0.0003266078,0.07112643,0.04290129,0.014825376,-0.06140862,0.07433742,-0.030675728,-0.037651002,0.038067393,0.055760466,0.003647216,0.02508269,-0.07903736,-0.036145695,0.009162267,0.078413054,-0.027654503,0.026715415,-0.01437469,-0.012865732,0.04148564,0.031976495,-0.08083756,-0.11544581,-0.048707075,-0.024218684,0.09936538,0.016467026,0.031825446,-0.024658104,-0.0011504866,0.0035363324,-0.06289958,-0.029398834,-0.007023499,0.049961545,-0.044061437,-0.045068003,0.036038563,-0.024775136,-0.038725317,0.038438044,0.09308781,0.026895426,0.009661411,-0.088368624,2.042056e-33,0.008526146,-0.030717047,-0.042430732,-0.035088453,0.042821612,-0.06332508,-0.042761967,-0.00408094,0.02014258,-0.04506465,-0.06836441,-0.0160343,-0.00016124503,-0.06827786,-0.031829268,0.060407825,-0.10730891,-0.021713581,0.033490583,-0.035583932,0.02518108,0.03519202,-0.000763666,0.03831915,0.009897893,-0.0031722474,0.002203094,0.051523358,0.049030572,-0.011844603,-0.049534667,-0.11090506,-0.124890715,-0.028214935,0.029115394,0.03078875,-0.034342553,-0.07590745,-0.04328677,0.08878299,0.020889593,0.0004642104,0.026279608,-0.021671114,0.062497422,-0.062849954,-0.039708916,0.10230888,-0.034896504,0.061120577,0.05361413,-0.057108507,0.035538483,-0.00044037413,-0.0708372,0.02242176,-0.048572265,-0.013002967,0.024642035,0.025772177,0.04806893,0.05564241,-0.048181977,0.04985612,-0.024479197,0.02578322,-0.08060307,-0.013204546,-0.03662925,0.111375354,-0.035583287,-0.06385231,0.048283793,-0.00026881736,0.08632143,-0.026812833,-0.052344847,-0.02288622,0.00778052,-0.015404129,-0.04723422,-0.07577505,0.009110962,-0.032999508,-0.028438628,-0.030795855,-0.028260186,-0.06486886,-0.019923827,0.019394448,0.06097775,-0.112350784,-0.025620814,0.10834209,0.0007521011,-3.0093247e-33,0.119967945,-0.06966315,0.09954792,-0.06587068,0.030906064,0.054707844,0.006621806,-0.012131783,0.046812642,-0.058642842,0.04474954,0.010084148,-0.004742817,0.020120328,-0.010033303,-0.014297527,0.048455976,0.053407665,-0.022665942,0.046558335,-0.056396738,0.035767503,0.056613736,0.0050755152,0.00857654,0.025636144,-0.041888922,0.076811135,0.06366516,0.0399371,0.03078116,0.04625143,-0.024968173,-0.019325018,-0.14128514,0.03500407,-0.016379867,-0.04575397,-0.008239322,0.0063740266,0.016134331,0.0046901093,-0.064396,0.07421373,0.054432083,0.0310758,-0.058844402,0.01549236,0.055586807,-0.06562628,0.021280948,0.012934814,0.01101685,-0.012013914,-0.0039989543,0.11996319,0.05743573,0.035676405,-0.011645437,0.020813974,-0.016950302,-0.07848655,0.06482953,0.02029791,0.07423637,0.013601338,-0.0048953854,0.12053067,0.015497662,0.05602038,0.10226697,0.089593105,-0.057641897,0.024663262,-0.03718571,0.04732828,-0.019263094,-0.008650994,0.019641155,-0.0024980872,-0.010770784,0.008939775,-0.052135635,0.05115329,-0.05337923,-0.06572252,0.00021631073,0.0965252,-0.020996718,0.007004903,-0.037261892,0.023515252,0.0071614604,0.020473791,0.04931248,-3.0401115e-08,0.0067657405,-0.031643376,-0.028783783,-0.081587695,0.070213735,0.08352822,-0.0013797821,0.071524344,0.0033229308,-0.11447617,-0.03032927,0.08797696,-0.07604553,0.011034641,0.041013397,0.046947934,-0.11731472,0.0023624918,-0.015305366,0.038641054,-0.08715122,0.00026563785,-0.058938574,0.055154722,-0.07095924,-0.053745117,0.11124867,0.07793951,-0.07153031,0.005644366,-0.0033105493,0.026856476,-0.03826454,-0.018967228,-0.041289367,0.029420532,0.008683009,-0.03372374,-0.0739678,0.077639155,8.700989e-05,0.019789107,-0.097073674,-0.04715981,0.012511367,-0.002703715,0.0044510574,0.022046216,-0.056271218,-0.01524482,0.08121643,-0.054166332,-0.08162334,0.016134942,-0.054448407,-0.035083853,-0.027049644,-0.07499497,-0.029001558,-0.017927233,0.010989711,0.006248607,0.23978867,0.005662756 +2.3.1.314,"The enzyme is found in plant chloroplasts and cyanobacteria. The plant enzyme can also employ acyl carrier proteins and galactolipids as acyl donors, while the enzyme from the cyanobacterium Synechocystis sp. PCC 6803 only uses acyl-CoAs. The enzyme also catalyses the activity of EC 2.3.1.20, diacylglycerol O-acyltransferase.",384,1.0,-0.14086412,-0.030994471,-0.13238649,0.033620656,0.086077526,0.07451082,-0.082883395,0.034371015,0.07041399,-0.044231985,0.06118201,-0.056000687,-0.13339965,-0.0009013154,-0.047902513,0.06952976,-0.05716789,0.022603016,0.003419052,-0.030474804,0.038102895,-0.008937983,-0.015736118,0.0033456786,0.057884224,-0.0694882,-0.00767583,0.026932549,-0.016580323,-0.03991413,-0.029078148,-0.044305697,0.039265126,-0.0066855247,0.09784421,0.036702715,0.00053807447,-0.13764733,0.06495066,0.022030687,0.025895223,-0.004621917,-0.025618484,0.065547146,-0.00074832834,0.0148598105,0.0028249712,0.017887704,0.03756936,-0.0807481,0.013704447,-0.018025264,-0.045479555,-0.023735834,-0.061799023,0.0618662,-0.03526122,-0.05819179,0.023944398,0.056960676,0.05494397,0.019779403,-0.007850315,0.03086456,-0.052355386,-0.094090104,-0.01593067,-0.027506994,0.10355766,-0.06113226,-0.0598554,-0.10475391,0.0018545314,0.07785979,0.0019334401,0.035401497,0.008236239,-0.041431166,0.038182046,-0.03682382,0.030237343,-0.0152735375,-0.019020451,0.04830102,0.020728344,-0.022383286,0.02398382,0.06407895,-0.042444337,-0.018750362,0.10880806,-0.011092063,-0.01973633,-0.10258256,-0.09403612,0.082977146,0.06561861,-0.014096655,0.036832824,-0.03443819,-0.0039868853,0.075693645,0.040536463,-0.09258368,-0.011611124,0.050241336,-0.06456156,0.074964635,0.04566723,-0.004788893,-0.08555658,-0.010914317,-0.022027992,-0.022408962,0.015601878,0.054996394,-0.032989055,-0.043885022,-0.015197248,0.06607455,-0.026013333,-0.0854593,0.009539782,0.10127058,0.01981794,0.09258031,-0.111730166,4.2503804e-33,0.038931143,0.034824092,-0.023478337,-0.07129095,-0.023933506,-0.052014288,-0.029580764,0.024211856,-0.047864534,-0.044005536,-0.06503077,-0.093881205,0.03841973,0.027094789,-0.03642109,-0.0062825438,-0.039421447,-0.03157799,0.036256786,0.05536238,0.020518396,0.019393375,0.037458118,0.038129583,0.04321182,0.017599544,-0.033954963,0.0011043968,0.09556755,-0.00076478795,0.030028349,-0.055025633,-0.033217274,0.03321751,0.054135762,0.0062815016,-0.033819925,-0.06879167,-0.01129069,0.08137297,-0.0019015415,0.033819113,0.042833153,-0.028155182,0.057505738,-0.01202823,-0.083209984,0.08896335,0.067435704,0.009258444,0.039707568,-0.0047292016,0.06200689,0.06131748,0.037648506,0.0014895278,-0.059931755,0.0275185,0.060746636,-0.029003393,0.042763725,0.07180272,-0.043289058,0.00064420764,0.023080392,0.0380919,-0.100463904,0.015715197,-0.038068496,0.061929535,-0.019349987,-0.046860766,0.009983279,0.04384938,0.06688989,-0.032454673,-0.05068429,0.032955617,-0.0098492615,-0.0032100098,-0.019156279,-0.03529645,0.09504428,-0.00990285,-0.037274484,-0.05945432,-0.06598505,-0.0052380376,0.0006530476,0.008338421,0.023844037,-0.0047823936,-0.040439595,0.026738591,0.00045565286,-5.2697882e-33,0.12854876,-0.09154391,0.051981866,-0.09138147,-0.054503374,0.069955416,-0.04510438,-0.056310132,0.049091592,0.02363526,0.07841173,0.01997528,0.065835364,-0.075341605,0.049875192,-0.005870965,-0.034796532,0.09345806,-0.005380433,0.03663881,-0.07175607,-0.0009781228,0.032904204,0.017167177,0.040725514,-0.029940888,-0.07030469,0.0035096223,0.044439927,-0.023510747,-0.032902244,0.027888233,-0.040338974,0.0075673037,-0.021671643,-0.01249808,-0.07316939,-0.011594343,0.02031112,0.09797435,0.040661525,0.019942038,-0.0010417625,0.0073429444,0.06613466,0.009380583,-0.02605917,0.04148809,0.011906199,-0.082863696,0.0354932,-0.015490699,-0.0023213085,0.020850666,0.051224228,0.11105499,0.06529097,-0.012026952,0.02246488,-0.06522975,-0.028903844,-0.08990406,0.01846755,0.0006022403,0.03337437,0.110713884,0.012903213,0.117487215,-0.032094173,-0.009998693,0.036662675,0.047295943,-0.014265105,0.023512123,-0.0543858,-0.0011484614,-0.07618038,-0.042009305,-0.03376253,-0.048946526,-0.017623642,-0.02720696,0.010551415,-0.025776166,-0.03065691,-0.004193191,0.015203278,0.045395166,-0.010732702,-0.010914441,-0.030774051,-0.016710706,-0.0105642835,0.05759344,0.099329114,-3.8702876e-08,0.0332594,-0.017938858,0.07118966,-0.11022445,0.027715053,0.033606034,0.02514946,0.024350816,-0.010070257,-0.012924127,-0.040081304,0.06747788,0.0064138,-0.021154702,0.020445153,-0.020492446,0.021699613,0.040514626,0.017442986,0.028656598,-0.057273626,-0.026739364,-0.050824836,0.063329294,-0.02971092,-0.028025173,0.02468445,0.071371175,-0.007378681,-0.01090941,0.009528088,-0.013791861,-0.0540733,0.0024361084,0.014640021,0.038935304,-0.013872101,-0.11839779,-0.072296895,0.071198985,0.025941303,-0.0105825765,-0.084761955,-0.0013025252,0.038590282,-0.02819258,0.049153112,-0.011755149,-0.048958715,0.01715265,0.019500244,-0.046829652,-0.07062457,-0.09030654,-0.047337797,-0.042200428,-0.025886584,-0.09237452,-0.0513661,-0.04466183,-0.04172014,0.01789249,0.2230493,-0.010673433 +2.3.1.315,"The enzyme, characterized from the bacterium Geobacter metallireducens, participates in an anaerobic degradation pathway for cyclohexane-1-carboxylate. In vitro, the enzyme can use butanoyl-coA as a CoA donor with greater efficiency than succinyl-CoA.",384,0.99999994,-0.09214894,0.0065483656,-0.06880607,0.03189741,0.036697194,0.025677057,-0.08659505,0.0009289759,-0.016163632,-0.058027964,-0.04720324,-0.09882672,-0.022488596,0.040179167,-0.091094986,0.0008219368,-0.017820358,0.029947313,-0.007084888,0.044388894,0.02347486,0.0066069947,-0.034423415,0.033733837,0.028022066,0.0005711308,-0.020466046,-0.014786768,-0.022885846,-0.0055917054,0.008937701,-0.016928408,0.06762682,-0.014354789,0.103466384,0.10729929,-0.03709705,0.00057585543,0.06542391,-0.0032062079,0.027545286,-0.0013687906,0.044124603,-0.009165078,-0.04947019,-0.08575796,0.063393064,-0.00036718498,0.03394865,-0.050055563,0.015864976,-0.02199128,-0.032550484,-0.0060357833,0.012038156,-0.00850423,-0.07613355,-0.057999436,-0.020417267,-0.01705637,0.072665915,0.03081106,-0.014543971,0.02232243,-0.010946213,-0.06081081,0.048620693,-0.009646368,0.035497516,-0.019565517,-0.07006228,-0.036959156,-0.070292,0.029663257,-0.011716558,0.04019609,0.08151501,-0.08950705,0.022448944,0.0019679077,0.020468298,0.0140426755,0.03568391,-0.009461664,0.021200612,0.0031025754,0.031399507,0.034057096,-0.019054648,0.00094197376,0.081169255,0.05638736,0.052657537,-0.06783686,-0.116991535,0.05526849,0.044348452,0.04843152,0.072162375,0.02241433,0.010207309,0.085925244,0.032383863,-0.10756805,0.0005361756,-0.029492857,0.0076759765,0.119071916,0.06889523,0.02184545,-0.030251479,-0.030026544,0.023148822,0.028653352,-0.02694352,0.05908416,-0.02919794,-0.017850023,-0.12701705,0.08626392,-0.010804546,-0.08300053,-0.0048041646,0.037148654,0.014616253,0.051032443,-0.036022484,1.8361034e-33,0.08520366,-0.031073712,0.04688473,-0.014193197,0.03150124,-0.044253018,-0.06884394,0.036053192,-0.038657255,-0.03758564,-0.022452062,-0.043272246,0.026251433,0.027561994,-0.04184218,-0.03647928,-0.09941633,-0.058535133,0.05033108,0.08398186,-0.022418654,0.04806106,-0.023118401,0.06004071,0.031363264,0.020111378,-0.020470483,0.046567697,0.00990801,-0.0041300613,0.009254566,-0.11640194,-0.13569494,-0.02141331,0.09351544,-0.06824892,-0.022929767,-0.022986164,-0.020716473,0.063688606,0.006796599,0.034516215,-0.06645055,0.016928611,0.11429476,-0.039700024,-0.01223722,0.1302611,-0.01878263,0.049469884,0.07411039,-0.013947647,0.04622292,-0.05005837,-0.006826975,0.08823812,-0.006435361,0.057304557,0.06343178,0.01926583,0.020367065,0.034376517,-0.026025765,0.04760648,0.050661888,-0.019180372,-0.06981109,0.034774583,-0.009803551,0.037981167,-0.087392084,-0.032069,-0.004679187,0.09121484,0.034597415,-0.009602316,-0.026750667,0.030849006,0.13202578,-0.035370905,-0.008025636,-0.024411049,0.008827579,-0.07219463,-0.025902975,-0.0048708427,-0.043235715,-0.061339553,-0.0002327144,-0.0015955534,0.045578577,-0.08080146,-0.06409893,-0.038395833,-0.013939984,-2.9424886e-33,0.11691335,-0.090680264,0.012107767,-0.049242128,-0.050116602,0.018629216,-0.0031198354,-0.058287535,0.017484851,-0.0071714595,0.087829426,0.025926977,0.06752423,0.013837792,0.032360148,0.004359782,0.060464296,0.0021446005,-0.10560157,-0.007832311,-0.01677364,0.064292856,0.010940954,-0.067199215,-0.027914474,-0.0116346,-0.072894394,0.05524645,0.06673041,0.12767297,0.040157918,0.0371624,-0.044345938,-0.093407474,-0.0995436,0.06550134,-0.025697216,-0.011365481,0.003769434,0.043140963,-0.021382915,-0.014084129,-0.032245897,0.027586592,0.027736412,0.04897054,-0.1295411,-0.0044036997,0.030886231,-0.019748751,-0.0068806554,0.013520622,-0.031846188,0.006798486,-0.00890384,0.050841574,0.08722978,-0.036942065,-0.028069906,-0.051129293,-0.041418474,-0.05168451,0.077862926,-0.0101091545,0.010672265,0.08462257,0.04873354,0.11070598,0.02433781,-0.07242908,0.10422969,0.032443445,0.03832505,0.0012033107,-0.06357447,0.024887582,-0.026891267,-0.03205964,-0.048890386,-0.020525953,-0.03811961,-0.021706235,-0.022157181,-0.06888192,0.0076863817,-0.074026845,0.031400666,0.05540179,-0.021287516,0.020678986,-0.030120177,-0.05135118,-0.014875198,0.06754811,-0.0073876753,-3.4718603e-08,-0.05531985,-0.034051586,0.029077636,-0.05758166,0.009757915,0.07172857,-0.023716956,-0.047990397,0.033386808,-0.031383973,0.03499935,0.06815942,-0.01891686,-0.002349892,0.07340351,-0.013162152,-0.016912047,-0.029681103,-0.040338103,0.022074185,-0.06758857,-0.0018178507,-0.04872466,0.058964524,0.008640238,-0.073912375,0.0949261,0.06790418,-0.038916677,-0.020093603,-0.019031843,0.04491828,0.0060113985,0.04844299,-0.031756196,-0.023882084,0.004577559,-0.024614194,-0.041803665,0.055082906,-0.010963203,-0.0057373904,-0.11475335,-0.0059392443,0.057753664,0.005854805,-0.023727134,0.12003968,-0.026284244,-0.017188184,0.023799283,-0.08074715,-0.1006036,0.0071584797,0.012821851,0.04039234,0.022032253,-0.015459699,-0.019179571,0.005657926,-0.053879064,-0.026738146,0.20005597,-0.08459118 +2.3.1.316,"The enzyme, characterized from the bacterium Acinetobacter baumannii ATCC 17978, participates in the biosynthesis of fimsbactin siderophores.",384,1.0,-0.1308854,-0.07087245,-0.13370119,0.044890754,0.010816233,0.05480246,-0.027251782,0.06281986,0.003896258,0.034644898,0.012192556,-0.114887886,-0.05481343,0.028850583,-0.06673666,0.042798195,-0.051792447,-0.01854924,0.011957331,-0.02830489,-0.009365993,0.069634505,-0.04436225,-0.01743636,-0.03877198,-0.028855797,-0.0007565359,-0.0076286704,-0.043059558,-0.029224304,-0.0012451268,-0.011675588,-0.008155523,0.020011958,0.0684505,0.04684904,-0.042152263,-0.093212076,0.1409246,-0.042853046,0.04407001,0.006102386,0.030581078,-0.050569795,-0.039662372,0.016956069,0.043728963,0.060278386,0.07233,0.034740787,-0.044850476,0.06742305,-0.06170081,0.036750086,-0.011113736,0.010928524,-0.019302985,-0.070392445,-0.02710185,-0.010383026,0.001613332,-0.041852195,0.041651636,0.033722177,-0.024755351,-0.093347326,0.04292822,-0.07508983,-0.0010827596,0.010631787,-0.04257631,-0.08659517,-0.029353974,0.020916592,0.045936223,0.040445235,-0.0038373999,0.029874694,-0.020339578,-0.060198504,0.025154838,-0.061727356,0.04822633,0.09880199,0.027278047,-0.09678171,0.029569212,0.016659362,0.038849767,0.070888,0.04702215,-0.014567403,0.0050685788,-0.08763356,-0.044793785,-0.008452026,-0.04063586,-0.0016381918,0.017976496,-0.043849,-0.06039242,0.030870423,0.058080077,-0.09411022,-0.03597865,-0.07681191,0.012940803,0.09553113,0.1097632,0.0067955563,-0.0054334463,0.0011011263,-0.021975027,-0.019892218,0.027808413,0.024052747,0.029700216,-0.05745793,-0.04690394,0.050129406,0.0029757167,-0.03231428,0.012904477,0.060287025,-0.06585237,-0.00257095,-0.14090121,2.0542374e-33,0.044459492,-0.02045149,0.031799212,-0.060584113,0.022527913,-0.017590983,-0.07481094,0.06478965,0.0032814033,-0.03866785,-0.08462794,-0.06455901,0.053936914,-0.025437687,-0.04490348,-0.0888663,-0.055606686,-0.075885125,0.054997582,-0.0040592575,0.033868667,0.07356574,0.0065037296,0.031949155,0.08254374,0.04800662,-0.0008341517,0.062715106,0.023286976,0.0044847494,0.013515672,-0.07713097,-0.071900986,-0.1030343,0.11662901,-0.017753007,0.0014157733,-0.025513083,-0.024116002,0.044574015,0.043023907,0.0063721198,0.017571617,-0.025880273,0.05827704,0.021048924,-0.070888415,0.0972315,0.06161056,0.07220577,-0.010478001,-0.04056532,0.104572594,-0.050375894,-0.015085245,0.03842118,-0.07352646,0.007974133,0.006526421,-0.035085566,0.051254146,0.022866333,-0.037531964,-0.009565773,-0.087452166,0.025015933,0.029320186,-0.004504151,0.0032222315,0.0058571165,-0.04669942,0.010508661,0.049704853,-0.009641632,0.08337618,-0.017158732,-0.04042039,-0.024329305,0.029258676,-0.031543337,-0.026169974,0.026934186,0.027081672,-0.0291717,-0.033975005,-0.059683353,-0.046691228,0.020622125,0.02601847,-0.06438257,0.07809938,-0.005373192,-0.025123034,0.03882381,-0.04909247,-4.443647e-33,0.027266324,-0.1431517,0.0025335914,-0.03305494,-0.029655596,0.02750398,-0.018636053,0.057159405,-0.024466442,-0.022926891,0.08303133,0.015455441,0.0023850524,-0.06494515,-0.01679662,0.024980647,-0.017079003,0.042234663,0.01899293,0.006035333,-0.026376497,0.02999382,0.09873825,-0.038712353,0.0001224998,0.058847684,-0.038630188,0.06802594,0.057493966,0.073094025,-0.06868166,0.018333863,-0.022071864,-0.08177848,-0.122281894,0.038583674,-0.021272996,-0.0027904036,0.053032,-0.005795373,0.08330812,0.021797657,-0.0146493735,0.08532628,0.00537835,0.056664977,-0.033246517,0.0012071343,-0.04630052,-0.104615755,-0.045510694,0.013198351,0.06756683,-0.05311081,-0.017086428,0.08039373,0.039057944,0.00162779,0.01800214,0.030818226,-0.012248154,-0.05496233,0.09339013,0.021671139,0.04364702,0.13086228,0.011354508,0.06924998,0.04302259,-0.04677925,0.07871735,0.012143275,-0.0599272,0.07276923,-0.02053862,0.026551709,-0.031536143,-0.066219494,-0.054415572,0.019647412,0.008677385,-0.012817098,-0.08206291,-0.013935973,-0.042335823,-0.06727801,0.06514774,0.04571389,-0.049228985,0.0049449163,-0.020037726,0.010324175,0.040969558,0.08999446,0.01121882,-2.935858e-08,0.013533351,-0.055632215,0.08507546,-0.036323834,0.0472923,0.06671577,-0.06172231,-0.04141821,0.033989675,-0.07413807,-0.03425759,0.03951238,-0.029933218,0.070268735,0.070622966,0.044683073,-0.10420615,-0.03448644,0.01037559,0.034441076,-0.044480532,-0.006886637,-0.11398906,0.054203644,0.04520475,-0.015528273,-0.060634,0.0042941766,-0.0643388,-0.0013353528,-0.030925341,0.047047675,-0.024805568,0.013272825,-0.12356119,0.014300594,-0.051243197,-0.07798437,-0.03672806,0.015386897,0.025157329,0.07023445,-0.07630254,0.029060286,0.050733965,0.025904998,0.05448454,0.01642589,-0.038551267,-0.045117587,0.038967237,0.027213188,0.015473035,-0.025109978,-0.084443174,0.015842773,-0.01854071,-0.06146233,-0.0068712966,0.01092207,0.002409546,0.05994305,0.11592087,0.040833794 +2.4.1.397,"This enzyme is the cyclization domain of cyclic beta-1,2-glucan synthase. Enzymes from Brucella abortus and Thermoanaerobacter italicus were characterized. The cyclization domain of cyclic beta-1,2-glucan synthase is flanked by an N-terminal beta-1,2-glucosyltransferase domain (a UDP-alpha-D-glucose-dependent synthase, not EC 2.4.1.391) and a C-terminal beta-1,2-glucoside phosphorylase domain (cf. EC 2.4.1.333), with the former responsible for elongation and the latter for chain length control. The cyclization domain of Thermoanaerobacter italicus cyclizes linear oligosaccharides with a degree of polymerization (DP) of 21 or higher to produce cyclic glucans with DP 17 or higher. The cyclization domain also disproportionates linear beta-1,2-glucooligosaccharides without cycling. The entire cyclic beta-1,2-glucan synthase from Brucella abortus synthesizes cyclic beta-1,2-glucans with DP 17-22.",384,1.0,-0.08498633,-0.045163646,-0.09212591,-0.0096095875,-0.03613853,-0.014986076,-0.073784195,-0.0031245584,0.0574918,0.00017553172,-0.004963537,-0.010764187,0.083648406,0.02130043,-0.059111156,0.02222575,-0.07771902,-0.025167918,0.0049305824,-0.0073633785,0.116260365,0.047735617,-0.033496387,0.026176758,0.029124677,-0.024153026,-0.02270459,-0.01988729,-0.09754182,-0.030620918,-0.0422661,-0.060533326,0.017277356,-0.0033507608,0.092371225,0.009384441,-0.049496204,-0.006542742,0.034823455,-0.041016217,0.04822711,0.060681805,0.05756024,-0.011559681,-0.06373286,0.019588001,0.011734942,0.017669184,-0.0058838446,-0.012516546,-0.012009731,-0.099040516,-0.042352054,0.0923344,0.0634246,0.013900146,-0.076994896,0.0064530596,0.067985095,7.425526e-05,0.021464529,0.00030785706,-0.033711545,0.01774139,-0.07269298,-0.07957998,0.028216608,-0.082540125,-0.116709605,0.019329123,-0.06836299,-0.027638407,-0.026656842,0.061739244,0.083184145,0.057718325,0.009363991,-0.023497352,-0.0018359928,-0.03275541,0.056133226,-0.008971543,0.09690984,0.01584372,-0.046905793,-0.004853934,0.052552424,0.0059994548,0.05438838,0.033579256,0.053082608,-0.014878094,0.026606712,-0.017696014,0.0085486965,-0.034217022,0.09328165,0.022028847,0.08250889,-0.033049196,0.0067808074,-0.041426882,0.07580897,-0.06628434,-0.033664398,0.037815098,-0.006827492,0.08540883,0.09469473,0.0029133437,0.004562738,0.041023966,0.051124625,0.0035989226,-0.057458755,0.061986502,-0.00044067096,-0.022383165,-0.013902519,-0.00860851,0.025897872,-0.033545204,0.035748396,0.050570138,-0.04284457,0.12586042,-0.082310386,1.1149876e-33,0.022523511,0.027528727,0.02543801,-0.009653032,0.029670207,0.014524895,-0.057881307,-0.0036003366,-0.04227464,-0.035349216,-0.061269537,-0.008336644,0.012254254,0.033619545,0.010826375,0.05498645,0.025293035,-0.0034684765,0.05583776,0.021038564,-0.013929533,0.08619858,-0.01674516,-0.02126005,0.07514572,0.02609603,-0.01489591,0.015390179,0.02104871,-0.003014787,-0.020080252,-0.042087175,-0.1431953,0.029215746,0.12419358,0.009989932,0.01625007,-0.029979665,0.009113152,0.019866062,0.007363351,-0.05171019,-0.021627722,-0.022222854,0.08346968,-0.016524954,0.020800095,0.039773326,-0.08879211,0.06674925,0.029364612,0.05401258,0.052723784,0.03316212,-0.07069537,0.07718647,0.0064210906,-0.08328181,-0.0036156985,-0.018551582,0.0037178649,0.040568527,-0.014103657,-0.044901367,-0.033600576,0.0071741077,-0.077604875,-0.041163057,-0.04040901,0.05436748,-0.039242454,-0.03650928,0.047511782,0.030033516,0.04307586,-0.006554115,-0.017102802,-0.010193719,0.03579823,-0.00760415,0.023733534,0.025561415,-0.039915286,-0.03664833,-0.01831364,-0.04275982,-0.016692441,-0.0053705308,-0.04644261,0.07258134,0.029216496,-0.056622397,-0.029116813,0.1311288,-0.016168663,-2.526087e-33,0.09463737,-0.12942158,0.066786446,-0.026875367,-0.038642876,-0.008909166,0.016742097,-0.07036834,-0.02367106,-0.11610472,0.10751602,0.07785504,-0.049199052,0.00241237,0.024401171,-0.067287356,-0.008416636,0.11098523,-0.06877846,-0.04144259,0.016380757,0.016124923,-0.033275317,-0.017531807,0.017851891,-0.00013686925,-0.04088663,0.09960741,0.11525597,0.061848674,-0.0421491,0.014534982,-0.0059201247,-0.0861049,-0.047567677,0.05855235,-0.065425776,-0.06142994,0.112256564,0.049158912,0.014110425,-0.00070196664,-0.09185253,0.009902475,0.11319301,0.118878104,0.0025542185,0.06671358,0.02781381,0.05029982,0.029758083,0.004405951,0.0041173166,0.026025932,0.027336081,0.0015355217,0.07255614,0.06671891,0.012950278,-0.0828098,-0.046495866,0.006157142,0.08385195,-0.0038412237,0.026880512,0.08705067,0.009613634,0.06361422,0.03235669,0.060233235,-0.0012878033,-0.006187155,-0.024488568,-0.019095736,0.012197521,0.012092585,-0.032808337,-0.10859166,-0.045083422,-0.05243242,-0.020432025,0.027585782,0.065418504,-0.01827398,-0.009089757,-0.04403479,0.08296791,0.053774673,-0.02419131,0.014034446,0.0085393395,-0.031328004,0.024844477,0.081006356,0.03915044,-4.2717595e-08,-0.013983796,0.0026970543,-0.019153254,-0.09603756,-0.0025535566,-0.012078073,-0.007716699,-0.009541713,0.07553302,-0.055675954,-0.009722083,0.100322776,-0.014941306,0.025807183,-0.032850634,0.029065091,-0.032486506,-0.05064636,0.0302468,-0.013981785,-0.09538315,-0.028200163,-0.13503583,0.036260556,-0.055843476,-0.1763304,0.018618375,0.054905728,-0.0064074476,-0.015661366,-0.03352162,0.05078522,-0.038982376,-0.04618797,-0.064259,-0.072700195,-0.07445071,-0.040988743,0.045674574,-0.00607699,0.07020835,0.02147384,-0.013353306,-0.0066634733,-0.024390854,-0.044047024,0.009547986,0.03750347,-0.020973492,0.019785559,0.011182409,-0.011190063,-0.05246083,-0.05918558,-0.076334305,-0.022500603,-0.009607245,-0.02802395,-0.029973526,-0.010994233,-0.09940864,-0.0396384,0.1262617,-0.05269156 +2.5.1.158,"This activity has been characterized from a number of fungal bifunctional enzymes. Following the formation of hexaprenyl diphosphate, a different domain in the enzymes catalyses its cyclization into a triterpene (see EC 4.2.3.221, macrophomene synthase and EC 4.2.3.220, talaropentaene synthase). cf. EC 2.5.1.82, hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific].",384,1.0,-0.012628732,-0.031040652,-0.08421646,-0.02886064,-0.0039082365,0.027932398,-0.06510203,0.04994959,0.05612333,0.029516354,0.071244255,-0.032434665,0.010649347,0.031365838,-0.080194466,-0.020664,-0.032888047,0.011203137,0.0345706,-0.056252263,0.102496445,0.04033263,-0.03234541,-0.028711116,0.03323508,-0.008591843,0.026961897,-0.047150556,-0.011462183,-0.08562861,-0.06211046,0.05352692,-0.027314803,-0.10367123,0.04858585,0.086582705,-0.051964086,0.0074530332,0.09152549,0.048751235,0.058074802,-0.078095235,0.019150404,-0.07429159,-0.06502121,0.03105761,0.023638869,0.0022098147,0.028801376,-0.0660887,-0.060865056,-0.01456409,0.055656005,-0.07923241,0.020167597,-0.018740516,0.00391687,-0.036157127,0.0026292962,0.043637946,0.022627737,-0.0069212043,0.0024238143,-0.03212158,0.0022439612,-0.035024982,0.016040351,-0.027612079,0.019211696,-0.042841658,-0.12370576,-0.011847622,-0.06516281,0.02267596,0.019708227,0.1107182,-0.02483888,0.013613611,-0.01496889,-0.041154835,0.073504105,0.032521103,0.04853387,-0.015583847,0.053890653,-0.00023879835,0.005314651,0.055555213,0.06999626,0.04981604,0.05133079,0.053585123,0.0029811864,0.0006993095,-0.10478319,0.07991994,0.048390582,0.06810452,-0.019010246,-0.06961901,0.073860735,-0.0019921914,-0.01423581,-0.04856189,0.0036992505,0.010531855,0.015582031,0.046370737,0.07939445,-0.01601452,-0.000841755,0.00017866428,0.035639778,-0.09363029,-0.06493015,0.061535493,0.012972395,-0.017478444,0.0050473837,0.011129919,0.027026035,0.016703185,-0.023454078,0.06442451,0.020972742,0.0017253178,-0.063276224,3.767534e-33,0.07376554,0.115366966,0.019806135,0.03831516,-0.037965503,-0.031928007,-0.023105409,0.025208311,-0.044088386,-0.05452506,-0.01692775,0.000851489,-0.010737946,0.052354116,-0.042032283,0.01363613,0.03485654,-0.025957355,0.067977086,-0.015285281,8.3917876e-05,0.041946918,-0.095064856,0.01562863,0.08125593,0.055426702,-0.051808283,-0.046286594,0.04037771,-0.034146935,0.020772014,-0.08950151,-0.061696798,0.021585472,0.087606445,-0.09891131,0.048016895,-0.022284044,-0.0671762,-0.013949537,-0.04329026,-0.009332909,-0.013151787,-0.052452233,0.03072995,-0.03084458,-0.05441044,0.0911685,0.02528937,-0.0032726792,0.07304805,0.017385792,0.090265706,0.06442341,-0.087165274,0.045728657,-0.03588179,-0.091968924,0.05509719,0.06366426,-0.0015521698,0.078130364,-0.1014314,-0.009311844,0.01383296,0.01288112,-0.05526033,-0.09342329,0.014129368,0.12020314,-0.02969378,-0.022656122,0.025051847,0.06446073,0.028480973,-0.009121553,-0.10841336,-0.047813393,0.053139396,0.046078186,0.04775742,-0.077309445,0.04361263,-0.065572485,-0.05889885,-0.016910974,-0.001464407,-0.09331707,-0.024776457,0.0383856,0.016091635,-0.05526453,-0.022340603,0.0546224,-0.0048596747,-5.1154965e-33,0.14462109,-0.036248982,-0.005183,-0.058423705,-0.079397984,0.075554855,-0.04365452,-0.060970142,-0.037321765,-0.030425452,0.037714846,-0.049513876,0.08354845,-0.016737731,-0.07103103,-0.008850908,0.044458393,0.09457214,0.016044563,-0.0012836559,-0.053044453,0.044479802,0.033804085,0.10010353,0.03857969,-0.026550947,0.04603082,0.027631404,-0.02301677,0.09847195,-0.024527438,0.0051584537,-0.010562951,-0.050849617,-0.064202555,0.06619743,-0.055269185,-0.0007847176,0.048224818,0.047351286,-0.016359799,-0.061582208,0.015246227,0.023434816,0.045111895,0.055787325,-0.07789258,0.095540464,0.016712243,-0.06495377,0.030298641,0.08114187,0.012860829,-0.014817364,0.031198874,-0.007679737,0.028036831,-0.036565833,0.034866937,-0.042712644,-0.015099424,-0.023265464,-0.03642687,-0.038430944,0.043930557,0.09007169,-0.05550933,0.041988373,0.035402294,0.011461424,0.054718003,0.03557658,0.030274143,0.0016443521,-0.03672774,0.050066873,0.020297615,-0.07046067,-0.012569681,-0.052740514,0.029397842,-0.017196296,0.048021387,-0.10798345,-0.10217001,-0.055921294,0.046204466,0.06755898,-0.018009502,0.00087933417,-0.00569919,0.03427688,-0.061333355,0.078701414,0.057676326,-4.5032987e-08,0.033881914,0.04915081,0.03491276,-0.07255494,-0.047980092,0.021116128,0.084826276,-0.045850612,0.061161768,0.02130112,-0.09784451,0.030329172,0.024686247,0.031533036,0.09551917,0.010236767,-0.019400883,0.035938524,-0.013546141,-0.022272194,0.024904916,-0.025911309,-0.12903568,0.026406037,0.0152988685,-0.13061221,0.057877235,0.00021906735,0.0261132,-0.00961472,-0.0047268863,0.01795901,-0.015046739,-0.015652105,-0.018798323,0.031706337,-0.060274515,-0.06479651,0.008262378,-0.012749753,-0.040027194,-0.03893872,-0.12958467,-0.015400429,-0.063818194,-0.00936653,0.022892283,0.020084854,0.04793595,-0.053381726,0.020026226,0.053000472,0.01704267,-0.036470298,-0.030416045,0.006717094,0.014529302,0.02464421,-0.04032465,-0.118007354,-0.016857954,-0.04611751,0.13495897,0.013921277 +2.5.1.159,"Requires Mg2+. The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, is involved in the biosynthesis of hapalindole-type alkaloids. ",384,0.99999994,-0.10042053,-0.04641978,-0.027401457,0.058925983,-0.05211353,0.019258678,-0.04556523,0.026905743,-0.056837697,-0.0026531417,-0.015242086,-0.046878397,-0.027985811,-0.043691415,-0.030856172,0.095249034,-0.022272551,0.09856533,0.029137684,-0.015758801,0.109810114,0.045947514,0.01620235,0.01640115,0.03466524,0.01776105,0.048636563,-0.007202327,0.044238403,-0.03525855,-0.016126089,-0.017430428,0.07936646,-0.08909281,0.083925486,0.065918,-0.071779534,-0.073970646,0.055540446,-0.00069694343,0.052536804,0.001412525,0.056060687,0.105569474,-0.05957014,-0.07005945,0.07235459,0.014494069,0.027178124,0.004457777,-0.060155854,-0.0009894733,-0.053241327,0.0046760314,0.017166935,-0.021958956,-0.11816769,-0.0065237074,0.054675583,-0.0030331581,0.039638955,0.06755768,-0.02726639,-0.03794523,-0.018831668,-0.013853315,-0.020577632,-0.094020054,0.05459093,-0.018685143,-0.0012191564,-0.08286942,-0.06898215,-0.023743883,-0.053823818,0.017745376,0.06530005,-0.049140327,-0.017052203,0.009494308,0.017930679,-0.024934826,0.11749307,0.06496211,0.028807689,-0.02567407,0.07901352,0.061606362,-0.028344972,0.06812782,0.106527485,0.006462532,0.0071143736,-0.076984376,-0.0036067446,0.059624925,-0.011008341,0.061281417,0.019216932,-0.00074112945,0.039846107,0.024508508,-0.02451879,-0.031020949,-0.050034564,0.0019028031,-0.020881802,-0.042647917,0.02068199,0.021037133,0.035179067,0.0063464884,-0.012277991,0.029770315,-0.015294912,0.07667212,0.015536991,-0.10398805,0.011610307,0.034924127,0.0018533048,-0.036831737,0.0022324566,0.03721743,-0.023557218,0.026431175,-0.08431471,2.4474084e-33,0.010119866,0.036495198,0.013268236,-0.027039463,-0.014203509,-0.06638336,-0.072450235,-0.050060507,-0.0717378,-0.039293926,-0.10813862,0.016032126,-0.034327805,0.014035349,-0.029763581,0.042409882,-0.036812294,0.021277625,0.13092944,-0.008567441,-0.058378607,0.040549517,-0.040617622,-0.012916142,-0.03281807,0.13883966,0.027197909,-0.026230805,0.061514113,0.00800296,0.042701524,-0.1387337,-0.03401552,0.01988968,0.01654961,-0.035088807,0.0023287358,-0.028444668,-0.05817454,0.0038275293,-0.05622302,0.09366691,-0.03686976,0.022796381,0.11195317,-0.071242675,-0.017009357,0.017545428,0.057210352,0.06736062,-0.03028472,-0.00816348,0.08560166,0.029884204,-0.04079192,-0.003881601,-0.0066597555,0.10645288,0.06855453,0.037871346,0.00039927318,0.018616296,0.03173777,0.050883647,0.094688445,0.03359994,-0.05029811,-0.047203287,-0.012745521,0.05872748,-0.033161853,-0.108095154,0.064173885,0.015420494,-0.006246855,-0.023851285,-0.0033768683,0.00075252325,0.016447192,-0.002238134,-0.019847173,-0.058429178,0.030952765,-0.019795531,-0.031745236,-0.048346374,-0.077553526,-0.061887655,-0.01052129,0.088935845,-0.003634747,-0.029771993,-0.09451482,0.0879169,-0.0075914045,-3.4800507e-33,0.0858447,-0.06292473,0.05017942,-0.060921196,-0.06317229,0.046909444,0.007520808,-0.038784444,0.044734333,0.045208823,0.10421174,-0.041206148,0.04712952,-0.040148344,-0.04857688,-0.07859973,0.043194294,0.13616407,-0.067071065,-0.0009593384,-0.034641903,0.10234854,-0.0013774366,0.03145714,-0.021820443,0.038674522,0.01972161,0.034344528,-0.020538261,0.06300985,-0.0073317196,0.058138996,-0.04711562,-0.0694363,-0.08555631,0.039547063,0.009602695,0.040234532,-0.011808977,0.08053442,0.03510718,0.060207985,0.027466444,0.06785747,0.047579147,-0.0024453986,-0.03549939,0.036163643,0.012143712,-0.13167901,0.034958433,-0.0076240264,-0.03798936,-0.035772588,-0.000548573,0.028759293,-0.0059008827,-0.006974242,0.05210613,-0.0041926396,-0.03205304,-0.057090256,0.038435753,-0.11481983,0.011808811,0.09848293,0.0079352185,0.05088176,0.025062604,0.034081537,0.042492386,0.058194757,0.021441912,0.057271097,-0.03793528,0.0652293,-0.021720827,-0.11865995,0.033416323,-0.06845293,0.04314075,0.0012379633,-0.028243989,0.002172345,0.0065155313,-0.04481723,0.028903004,0.09761191,-0.009932193,0.007244292,0.006931421,-0.031517565,-0.09384281,0.10111595,-0.035400905,-3.3073754e-08,0.02254021,-0.06332569,0.0024477881,-0.045055337,-0.0022696233,0.07848625,-0.04797561,-0.029661482,0.031399187,-0.031567,0.008430738,0.006873803,-0.020316215,0.028087474,0.0723009,-0.00020643757,-0.0031258573,0.009553398,-0.038832795,-0.010227565,-0.073052794,-0.008802272,-0.026902514,0.01580458,-0.0049453164,-0.07945073,0.04395992,0.020205617,0.0009922663,0.030338533,0.026674846,0.010686482,-0.04484412,0.038784217,-0.081056446,0.012384809,-0.03981598,-0.052981663,-0.017616065,-0.07554401,-0.03894656,0.015150202,-0.02644173,0.0020278946,-0.052849896,0.014358692,-0.034635942,0.026421074,-0.04374909,-0.025178764,0.011602786,-0.102527484,-0.06900538,-0.062332302,-0.052476674,-0.006699913,0.02567754,-0.057758346,-0.056879718,-0.12917876,0.08674304,0.01118033,0.110164806,-0.047151357 +2.6.1.125,"Requires pyridoxal 5'-phosphate. The enzyme, characterized from several bacterial species, is known to participate in L-arginine degradation and in the biosynthesis of the rare amino acid (3R)-3-methyl-L-arginine. The enzyme from Streptomyces arginensis also catalyses the activity of EC 2.6.1.126, L-aspartate:5-guanidino-3-methyl-2-oxopentanoate transaminase.",384,0.99999994,-0.05397664,-0.11266565,-0.12072505,-0.025870504,0.06752784,0.06388031,-0.034943983,0.04984121,0.048519216,0.005281627,0.0028656728,-0.011579179,-0.09925305,0.032630395,-0.062482294,0.029537873,-0.11836948,-0.05650062,0.030222233,-0.08322228,0.08885946,0.075975254,-0.029093746,-0.07315438,0.074073695,0.0042217,0.012340747,-0.046700425,-0.0029022421,-0.089588135,0.04099211,-0.049582295,0.039851278,-0.10610429,0.093445055,0.14126492,-0.10550143,-0.09704568,0.08732932,0.0134992255,0.0071655354,-0.046393722,-0.030027263,-0.034953404,-0.023014521,0.022411821,0.10767507,0.045378376,0.049385272,-0.049519118,-0.034878664,-0.039669186,-0.039067544,-0.05084837,-0.03412182,0.01705709,-0.037496075,-0.021193549,-0.021926092,-0.030542172,0.040080708,0.020719979,0.021138052,-0.0404448,-0.07137382,-0.044023827,0.07532532,-0.093895555,0.069876224,0.019817421,-0.08847398,-0.056384187,0.019941693,0.0512256,-0.044148218,0.030899676,-0.027685635,-0.06362455,-0.015737072,0.001871184,0.03587418,-0.046693053,-0.02171823,0.055421937,0.054470073,-0.050227612,0.001073931,0.020880165,0.070438,0.034867786,0.057530914,0.008319049,0.022772366,0.0077338973,-0.037404463,0.014855239,-0.03688398,0.045973618,-0.01714922,-0.031401064,-0.020258898,0.080971226,-0.0324239,-0.025320712,0.043349087,0.023227936,-0.0060989237,0.081080586,0.035667095,-0.038681585,-0.04943007,0.0022414124,-0.032244492,-0.007455566,0.00055090484,0.072433084,0.09610474,-0.08510156,-0.09936661,0.05003432,0.010773278,0.028057188,0.081170864,0.058341753,-0.06048486,0.023958556,-0.050260816,1.779217e-33,0.011519914,0.060113825,0.015258849,-0.029828953,0.021375824,0.034525115,-0.13290961,0.0018434433,0.025755351,-0.043301526,-0.07428996,-0.074647725,0.06304245,0.03814978,-0.012434115,-0.0013445314,-0.020604912,0.055142205,0.064598985,-0.0074939397,0.015702756,0.015638303,-0.029724473,0.05780241,0.0021511957,0.06062717,0.10118831,0.01973732,0.042483084,-0.015036416,-0.0035183579,-0.1271003,-0.08154755,-0.041280262,0.045857582,-0.02521476,-0.020242173,-0.011572353,0.037574742,0.074635334,-0.019588625,0.05169844,0.018112998,0.018963495,0.037227638,-0.09325693,-0.027420018,0.10652264,-0.011042015,0.04515166,0.016471399,-0.06565029,0.114378534,0.013827386,-0.039013084,-0.028686224,-0.034752067,0.053165678,0.08692282,0.04491373,0.04341619,0.034111947,0.019219229,0.010902072,-0.011133862,0.039759,0.019758578,-0.049588393,-0.010930114,0.061048415,-0.085237764,-0.014755885,0.07588906,0.00900091,0.004041987,-0.049785297,-0.087249324,0.0065388205,0.041899066,0.011211221,-0.041989684,-0.019355945,0.022514043,0.009281987,-0.036989227,0.0046165967,-0.0084745055,-0.037111353,0.04302619,0.061437435,0.0032480566,-0.08585387,-0.10246464,0.03790518,0.030925531,-1.1811902e-33,0.09796754,-0.07513735,0.03481911,-0.062430125,-0.06027822,0.03003577,0.049012255,0.02958312,-0.024740372,-0.03279482,0.05448429,0.028405942,0.03717968,-0.03787024,0.027070828,-0.040046293,0.013236416,0.090760365,0.026584432,0.015437422,0.03036261,0.014317311,-0.022470905,0.011579429,0.06335182,0.07145511,-0.018730646,-0.0484499,-0.008123118,0.026572876,-0.026426896,-0.046148345,-0.038568426,-0.056220606,-0.0355413,0.074250974,0.00284138,0.046889924,-0.0150155565,-0.02726532,0.06775154,0.068562984,0.035847798,0.07123373,0.01182807,0.03835891,-0.03236833,0.016685357,-0.022543944,-0.0999324,0.050676107,-0.03426884,0.010286771,-0.01858864,0.031842083,-0.048277635,0.014544517,-0.01254575,-0.05620505,0.032597136,-0.011559898,-0.06863511,0.033230696,-0.022949645,0.079871416,0.041815765,0.00050034956,0.10714652,0.00880348,-0.005594214,0.06962233,-0.011948796,0.03303304,0.06869956,-0.028043637,0.0021196303,-0.040454384,0.017300688,0.058873873,-0.05435781,0.014769283,-0.084895246,-0.019986255,-0.07087101,-0.027011467,-0.06976073,0.07414761,0.086774,0.040698484,0.038662415,-0.082983166,-0.028572408,-0.056560844,0.0417577,0.06341835,-3.8938296e-08,0.04617131,-0.0022807715,0.057915743,0.0022727575,0.05258125,0.055580292,-0.024675295,0.010399361,0.07321932,-0.028600106,0.00088972435,-0.0018617531,0.04433524,-0.007072251,-0.008344401,0.049653217,-0.06259927,0.06687489,0.020710109,0.009498354,-0.08926967,0.03443635,-0.111015275,-0.0075309714,0.07495916,-0.05231115,0.03737695,0.04111595,-0.022460256,-0.031461436,0.021678891,0.006850006,0.0025745523,0.025995934,-0.04996833,-0.0043148226,-0.056379907,-0.058216315,-0.048578832,-0.004636896,-0.0832949,0.035126194,-0.060584284,-0.012756623,-0.025096074,0.06522752,-0.01854133,-0.007787263,-0.060215764,-0.015892034,0.07276982,-0.05210618,0.01164588,-0.031008791,-0.106839284,0.031360634,-0.010601014,-0.08694202,-0.008362185,-0.07713212,0.03637666,0.0028066358,0.1316475,-0.009453947 +2.6.1.126,"Requires pyridoxal 5'-phosphate. The enzyme, characterized from several bacterial species, participates in the biosynthesis of the rare amino acid (3R)-3-methyl-L-arginine. The enzyme from Streptomyces arginensis also catalyses the activity of EC 2.6.1.125, L-arginine:2-oxoglutarate transaminase.",384,0.99999994,-0.038275506,-0.08676209,-0.13156891,-0.05057922,0.025996933,0.046667617,-0.03234888,0.023352336,0.05336259,0.03436263,0.0054339934,-0.034982264,-0.07496282,0.04143428,-0.024689715,0.018871369,-0.13137023,-0.045254566,0.04122982,-0.09465531,0.11765149,0.085693546,-0.018718746,-0.06470159,0.047908973,0.0026552964,0.013068387,-0.036804747,-0.00974176,-0.075297914,0.026893917,-0.06492296,0.040694088,-0.11977267,0.10081003,0.11147915,-0.10913529,-0.08659627,0.093052484,0.02759761,0.0018774616,-0.051247142,-0.030371435,-0.032368377,-0.035914753,0.009064748,0.12301984,0.041459035,0.045289505,-0.053734437,-0.029945092,-0.031342912,-0.040882196,-0.052678164,-0.015535407,0.027640812,-0.02891749,-0.004940906,-0.01277427,-0.056427807,0.036462005,-0.0044156294,0.012606288,-0.033699214,-0.063307784,-0.06684148,0.06340281,-0.09406937,0.05037508,0.0063204607,-0.09159533,-0.07265211,0.012294503,0.058864318,-0.029321162,0.0031282802,-0.016496785,-0.06834284,-0.017428048,0.01141773,0.023720253,-0.049766786,-0.022225197,0.08936103,0.06731374,-0.035064902,0.008347437,0.019035587,0.0312748,0.03771388,0.061591208,-0.02304901,0.01570655,0.015320921,-0.027472867,0.026389701,-0.05011829,0.040111903,-0.0016498382,-0.03830699,-0.011390432,0.07870299,-0.018873205,-0.012657268,0.02647718,0.015277798,-0.023484128,0.09913677,0.021319011,-0.020769091,-0.03839413,0.0036208825,-0.039643697,-0.0074388036,0.008003254,0.087707154,0.09319728,-0.09804975,-0.08255693,0.04300623,0.014824521,0.011967366,0.08383716,0.08357696,-0.054750126,0.019585177,-0.059622712,2.169595e-33,0.021282576,0.08126017,0.030899411,-0.017659424,0.01451144,0.047351267,-0.13064766,0.0041789366,0.02152367,-0.043796454,-0.10294354,-0.055478856,0.096367,0.037344195,-0.012100225,-0.0056746383,-0.03993467,0.03961933,0.07417605,0.00025505252,0.014485762,0.028473582,-0.025509665,0.053550534,0.012069606,0.06308425,0.072056696,0.004732031,0.039885536,-0.009192368,0.015873294,-0.12574577,-0.065245695,-0.046344217,0.05255502,-0.028413247,-0.007831487,-0.014743678,0.03264113,0.07913335,-0.019611506,0.03160683,0.022707466,0.009466904,0.06632643,-0.06047011,-0.043648824,0.11090905,-0.016624812,0.06801212,0.03832769,-0.039098177,0.13809691,0.013804565,-0.049979433,-0.017392777,-0.014551212,0.036912464,0.087962545,0.0642998,0.029302223,0.024614576,0.017792962,0.044524714,-0.00932158,0.024289677,0.027649736,-0.043297417,-0.02335223,0.06501723,-0.086148255,-0.00586871,0.075376816,-0.008105975,0.0007710443,-0.047499135,-0.08065731,0.031125695,0.024206372,0.013452689,-0.050906163,-0.029434768,0.01659076,-0.006626547,-0.022981988,-0.009308911,-0.0113002,-0.031956535,0.033352673,0.06710947,0.028504234,-0.07739865,-0.1154407,0.050973587,0.027315645,-1.9087668e-33,0.1212055,-0.10421159,0.02526641,-0.08355563,-0.047068015,0.035238296,0.04949878,0.019948833,-0.01976009,-0.028014392,0.070810415,0.008982762,0.03051065,-0.040181875,0.02895899,-0.051858034,-0.012401486,0.08402125,0.03361456,0.035342533,0.045767244,0.04270923,-0.022455629,-0.00044653946,0.055575673,0.057019196,-0.031857636,-0.026886446,-0.0043972447,0.0027974674,-0.040235095,-0.041764945,-0.025681594,-0.054504864,-0.04062904,0.085943185,-0.0008295651,0.06294607,-0.0077530076,-0.02330175,0.057311494,0.06712947,0.027769532,0.061056346,0.007573808,0.040935345,-0.02378594,0.011595149,-0.038981237,-0.09790606,0.05838356,-0.031319033,0.03138716,-0.014901851,0.045082517,-0.052356064,-0.011450942,0.006925575,-0.026287425,0.04117958,-0.013646079,-0.06120433,0.04570065,-0.017893722,0.07187884,0.013016349,-0.022930618,0.07270989,0.014418726,0.026524901,0.06271083,-0.013347031,0.011088316,0.06632231,-0.037270136,0.016581805,-0.05542912,0.0006621287,0.04187416,-0.05082148,0.004850754,-0.06577934,0.0075657945,-0.05474795,-0.03393128,-0.053898312,0.076926835,0.061615992,0.03233329,0.022816215,-0.07024693,-0.0077739106,-0.022726078,0.03913818,0.050600123,-3.799622e-08,0.027744384,-0.0017003919,0.0526935,-0.0014563473,0.050613083,0.048707835,0.00113664,0.005360528,0.05676694,-0.05217118,-0.0007961309,-0.0013220464,0.0658379,0.0053266943,0.0076204943,0.047853526,-0.06297345,0.036171276,0.016670194,-0.025571031,-0.11365844,0.026592545,-0.1233077,0.0014593924,0.07378098,-0.05354032,0.028365467,0.0310284,-0.015276476,-0.027990688,0.013309192,-0.015128157,-0.01870847,0.0053547625,-0.08339666,0.0045902054,-0.04800664,-0.062386744,-0.055045094,-0.032921128,-0.06449138,-0.0066538677,-0.052277658,-0.015616235,-0.02087862,0.06440861,-0.033769272,-0.017157316,-0.04685835,-0.043564375,0.07422971,-0.04961819,0.011327805,-0.042536125,-0.1308753,0.043974556,-0.01621954,-0.07640227,0.0047562593,-0.056051444,0.05046093,0.020883167,0.13912542,-0.020953761 +2.7.11.36,"Requires Mg2+. Peptide array data suggest that MASTL prefers to phosphorylate Ser over Thr, followed at position +1 by a bulky hydrophobic (Met, Leu, Phe or Tyr) and with an aromatic residue in the -2 position [4]. Its main role in animal systems is in the regulation of mitosis by phosphorylating a conserved site on endosulfine family proteins (ENSA and ARPP-19 in human), causing them to inhibit the protein phosphatase 2A-B55 [protein phosphatase 2A (PP2A) holoenzyme complex containing a B55-family regulatory subunit] [2].",384,1.0,-0.065543495,-0.036782008,0.023220064,0.019229408,0.064455695,0.004898948,0.018949028,0.031232506,-0.00988453,0.06720567,-0.0057970053,0.056157954,-0.01983969,0.07497087,-0.008149702,0.050126716,-0.043938566,0.011263666,-0.0006275213,-0.024513366,0.111422144,0.012539804,-0.009564111,0.023918923,-0.04734364,-0.058655273,0.04903114,-0.02949493,-0.04040414,-0.03788339,-0.00856118,-0.006013494,-0.021289034,-0.091117255,-0.051737715,0.07444719,0.028461844,-0.06629739,-0.022941105,-0.12714149,0.12068278,0.015905416,0.03419539,-0.0029744506,-0.008210693,0.012270904,0.00065386074,0.015849583,0.10564769,-0.010472181,-0.061251484,-0.054844957,0.046599735,-0.022499677,-0.018219851,0.064507715,-0.104739375,0.03527819,0.07211923,0.014568243,-0.07276258,-0.038413092,0.004867451,0.022132687,0.099433,-0.009575836,0.017524486,0.030124886,-0.02028755,0.053366084,-0.040934823,-0.0423568,0.039049488,0.040974442,-0.010975773,0.06499338,-0.037829064,-0.028856719,0.021237839,0.012481412,-0.06252064,-0.029762352,0.045882035,0.121051796,-0.015811495,0.031165127,-0.023093613,0.02383081,-0.011502103,0.027597662,0.042317715,-0.05837366,0.040145822,0.032645013,-0.036158137,0.055528354,-0.021629205,0.07721876,-0.0688646,0.009103088,-0.049226694,0.036864,-0.04592255,-0.07637372,-0.03662194,-0.002583547,-0.026097078,0.023864591,-0.025892384,0.015743164,0.056837976,0.038640477,0.0075798566,0.0011983827,0.019041983,0.0145856645,-0.009040437,-0.13484031,-0.025846804,-0.07757745,0.044136975,-0.026745563,-0.00873299,-0.0020699692,-0.020768072,-0.02634986,-0.074993566,4.1089736e-33,0.0067568845,-0.038522635,0.12172995,-0.008182644,-0.004864654,-0.028873477,-0.04536331,-0.03193178,-0.007677171,0.012335117,-0.0176848,-0.088489,0.037667632,0.017276453,-0.01053562,-0.074442856,0.051874775,0.05035883,0.058097553,-0.03913421,-0.052459486,0.06991605,0.008671815,-0.063239105,-0.026796257,0.11093097,-0.02691893,-0.113660075,0.0833795,0.051134903,0.056446824,-0.080609985,-0.07183649,0.05528646,0.003807992,-0.048727088,-0.069406375,-0.074934155,-0.028526863,-0.03517237,0.0077265394,-0.026299506,-0.050625395,0.082500435,-0.045437653,-0.11342006,-0.021729037,0.0062466837,-0.010383516,0.050158408,0.045737177,-0.058128215,0.020564254,0.003592777,-0.055124663,-0.04498446,-0.038058575,-0.040527318,0.012817361,0.018745301,0.05664799,-0.031465173,-0.019376641,0.07003203,0.07373316,0.061810203,-0.07377994,-0.11041927,-0.034498915,0.14006288,0.053668436,-0.040711846,0.0761963,0.060126312,-0.036411997,0.007341821,0.015376983,0.05036508,-0.043112744,0.12675554,0.020553278,-0.04161698,-0.09092693,0.08178563,-0.041000452,-0.010986537,0.023820883,-0.030067239,0.0374827,-0.005638249,0.045516733,-0.035650406,0.0066021117,0.058196567,-0.04629454,-6.5660565e-33,0.063653864,-0.0026227988,0.12621683,-0.13786215,-0.102129065,0.01494652,0.095199466,-0.035496924,0.05004969,-0.0049638385,0.07412721,-0.026399454,-0.011334724,-0.005962498,-0.04473639,0.0023456411,0.014540762,0.007377641,-0.027647773,-0.07554431,-0.013811648,0.08397048,0.05333638,0.1157866,0.03802471,-0.016638746,-0.060299322,0.041960847,-0.019072676,0.056358214,0.007924726,0.08600624,-0.0041765585,-0.07272763,-0.0075027943,0.021458322,-0.08826211,-0.03702979,0.014959561,-0.04529717,-0.058408212,0.0033136534,0.09534652,-0.016767845,0.07897715,0.010870871,-0.063957304,0.08333837,2.3509798e-05,-0.023842042,-0.012084423,0.04303473,0.012783954,-0.012681729,0.048435174,-0.02700447,-0.043064203,-0.05658344,0.058368925,-0.04978006,0.023680659,-0.080541715,-0.0067999987,0.04131372,-0.0029390887,0.042201992,-0.028919399,-0.07421532,-0.03327581,0.0362157,-0.014242044,-0.027916458,0.015523717,0.036911745,-0.06554652,0.022193588,-0.059135634,0.030457914,-0.0035437872,-0.0035956458,-0.058145996,0.05300569,-0.071016066,-0.038317613,0.032625295,-0.1103125,-0.011310063,0.06524371,0.037319582,-0.021414187,-0.090372674,-0.061823245,-0.10870425,0.06503509,-0.038179863,-4.640621e-08,-0.005451363,-0.061860174,0.055806253,-0.03837855,-0.07133756,0.069168754,-0.061806567,0.02582689,0.013584387,0.007279329,0.021916715,-0.0046848427,0.032835305,-0.004510689,0.010510288,0.050190672,0.032430265,0.02675801,-0.012850956,-0.08623045,0.034049302,-0.10348708,-0.029639252,0.048609264,-0.023942946,-0.010589107,0.021740982,0.09605056,-0.03151339,-0.05233824,0.0785466,-0.0060071037,-0.017918304,0.015287793,-0.0013851421,0.07582521,-0.048991557,-0.023157626,-0.03399642,0.055193294,-0.07064132,0.015555549,0.039736893,0.033039752,-0.0030408585,0.0026695558,0.09966152,0.035045296,-0.024795726,0.0028055105,0.01517546,0.0015139865,-0.051185835,-0.05581827,-0.08596771,-0.01914813,0.03141951,-0.047506247,0.029358244,-0.035913676,0.10727564,0.014652771,0.015778407,-0.003797401 +2.7.11.37,"Requires Mg2+. MAST (Microtubule Associated Serine/Threonine) kinases are eukaryotic-wide kinases with roles in microtubule function, PTEN regulation and a variety of neuronal functions. They are found in most eukaryotes, though lost from most fungi and ciliates. MAST kinases associate with their substrates via their PDZ domains. Substrates include the PTEN phosphatase (EC 3.1.3.67) in human and nematodes, and Dlic (Dynein light intermediate chain) in Drosophila. The latter is phosphorylated on Ser401.",384,1.0,-0.08018538,-0.032919712,-0.0010449833,-0.029389955,0.013486788,-0.018415693,0.03748225,0.024486711,-0.04191471,0.099163294,0.0360574,-0.015067658,-0.049373038,0.11778923,0.0039571538,0.053431805,-0.08398028,0.05017409,-0.009467826,-0.018295825,0.065919854,0.06981972,0.036064297,-0.01118527,-0.06446917,-0.07651659,0.0106464755,-0.0040551717,-0.0066016032,-0.028309466,-0.085651405,0.008776946,-0.047981363,-0.03834865,-0.024312446,0.051625915,-0.048864994,-0.06813882,-0.023461722,-0.08624047,0.19062103,-0.017976137,0.038833186,-0.006032899,-0.008247503,0.04010307,0.026364766,-0.00052782556,0.087640785,-0.012701522,-0.043558586,-0.048284866,0.05307782,0.009381359,0.014332704,0.03935161,-0.032248657,0.032478724,0.09932522,0.022905841,-0.013132944,-0.03766185,0.0043571377,-0.02478118,0.12883054,0.0102212345,-0.037062682,0.019640703,-0.032019258,0.020119742,-0.04148446,-0.06770937,0.009381491,0.07720751,-0.03181789,0.09135654,-0.029141217,0.00045776868,-0.037012424,0.014852293,-0.062494833,-0.008393494,0.059195288,0.08439093,0.015135487,0.06875182,-0.008295522,0.02698665,-0.032672998,-0.011593726,0.021412883,-0.00043287026,-0.034876358,0.00813654,-0.040715437,0.0019356124,-0.0017635407,0.07643909,-0.050789487,0.0006855282,-0.010009632,0.046861485,-0.04676592,-0.036806602,-0.07431576,-0.011391548,0.011953122,0.0034328154,-0.045572594,-0.009212571,0.024904417,0.0098740775,-0.012980339,0.047219817,0.03962875,-0.08059589,-0.0013316046,-0.0943965,0.08413314,-0.046175364,-0.024365762,0.015275858,-0.0014688532,0.008561722,-0.041987926,0.000786363,-0.11866331,9.6703595e-34,0.0010165158,0.006376629,0.06727132,-0.054701943,0.019173136,-0.0028208965,-0.013596962,-0.060530238,0.0028046416,-0.10402241,-0.10943771,-0.013378729,-0.0043284874,0.027470218,-0.039426733,-0.10939062,0.05591123,-0.009975209,0.08259758,-0.0017432931,0.005164199,0.05763028,-0.02375816,-0.04560416,0.007943303,0.050808515,-0.06292395,-0.032362208,0.0038892052,0.02311298,-0.0304207,-0.04209718,-0.009552033,0.07275824,0.04235985,0.013336092,-0.08421477,-0.038933177,-0.0639906,0.0016985646,-0.0012150893,-0.046385594,-0.09242262,0.058906637,-0.079734325,-0.048190538,-0.0037905273,-0.011767325,-0.0251514,-0.036004465,0.09561923,-0.01814375,0.008006915,-0.10487539,-0.056239713,-0.0067172744,-0.08109469,-0.024299527,0.022522863,0.005030643,0.039961398,-0.061231725,-0.01221352,0.13936116,0.080657184,0.09749481,-0.09737503,-0.05220036,-0.011219537,0.0357651,0.03485991,0.03293771,0.113063246,0.035532694,-0.008165168,0.04314936,0.001121901,0.023671936,-0.093241744,0.07490534,0.034035098,-0.06679315,-0.11229885,0.053324405,-0.028221428,-0.012517261,0.056658365,-0.0035093604,-0.009950419,0.0087552825,0.018608386,-0.029469026,-0.004661239,-0.008928722,-0.014474335,-4.1199156e-33,-0.0009539272,0.041961163,0.059055526,-0.04240858,-0.054966062,0.079709284,0.039348807,-0.07079461,-0.024795203,0.01406704,0.03798793,-0.0013238937,-0.008963384,-0.018730937,-0.06460968,-0.0061600767,-0.011248638,0.045322593,0.022791099,-0.078246,0.012137252,0.12382297,0.034738835,0.12826914,0.018326366,-0.028288718,-0.033645153,0.06651978,-0.061787575,0.049505744,0.01628195,0.12319035,0.017647047,-0.06304016,-0.0076222382,0.03267087,-0.047322497,-0.057430055,0.05768622,-0.050246153,0.010278746,0.0026398557,0.050023444,-0.0065494813,0.024936331,0.060295563,-0.029756999,0.05605174,-0.040256735,-0.018504342,-0.013213745,0.06112705,0.021438992,-0.088070914,-0.007917691,0.046005882,0.044896975,0.018177576,0.08482312,0.014196686,-0.057057474,-0.13152921,0.01858362,0.061518457,0.023030402,0.018258862,-0.0043100817,-0.0031725927,-0.031220466,0.07850785,0.06370001,0.03532919,0.04805129,0.060290415,-0.10108564,0.04396025,-0.021962889,0.037384883,0.010036445,0.0022038156,-0.053362086,0.030458594,-0.0357172,-0.012999005,-0.003611798,-0.05299477,-0.004478114,0.051329937,-0.030502014,-0.01607957,-0.025274519,-0.063374296,-0.12944898,0.05673889,-0.03513888,-4.184707e-08,0.10202729,-0.00836749,0.0162326,-0.029118773,-0.014563565,0.008267314,-0.030522814,0.07356759,0.049348656,-0.016727272,0.056614626,-0.073483504,0.017062413,-0.009106051,0.0431668,0.0818743,0.04993778,-0.0028308684,-0.0045316825,-0.07004366,-0.025712492,-0.06354874,-0.008242094,0.07390082,-0.042783238,-0.038896218,0.025492586,0.1538008,-0.005069933,-0.077315316,0.05007865,-0.003165819,-0.042233106,-0.03966666,-0.07205822,0.06164444,-0.04695491,-0.07593315,0.0017097284,0.045627482,-0.070753686,-0.01701727,0.0718586,0.0062534316,-0.076636665,0.012124887,0.08728668,0.011153356,-0.002515763,-0.04645991,-0.0035079008,0.08686792,0.0042050453,-0.044232324,-0.07737693,0.04073077,0.006121231,-0.009946262,-0.04998931,-0.045689348,0.048306916,0.045765586,0.041168757,-0.017948061 +3.1.2.33,"The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in an L-carnitine degradation pathway.",384,1.0,-0.11191277,-0.016397057,-0.06809553,0.015840882,0.048643634,0.055460107,-0.084744155,0.0920022,-0.002243412,-0.025058359,0.0036934358,-0.034095712,-0.04469705,0.07163371,-0.095742054,0.047745954,-0.103666596,-0.010400472,0.013081958,0.05293328,0.0833142,0.09810619,-0.057967838,0.05954476,0.08438481,-0.008538936,0.006777818,-0.015412586,-0.009093789,0.004737517,-0.05110282,-0.088287346,0.13009726,-0.06352547,0.053344976,0.069064595,-0.04321996,-0.036579296,0.11966095,0.013103254,0.0036944954,-0.023759328,-0.06664083,-0.09095393,0.04004665,0.0057073846,-0.04253478,0.037366353,0.024906518,-0.006150872,-0.06377908,-0.064572796,-0.033135977,0.039529316,-0.04201774,0.024067055,-0.01864793,-0.032921232,-0.029661814,0.07081131,0.029855672,0.025083257,-0.018112175,0.015449715,0.023938367,-0.03999435,0.044702798,-0.034665972,0.05150072,0.02586255,-0.07429154,-0.060670976,0.0024803134,0.049729664,0.013650141,-0.0616238,0.012230558,0.040295,-0.01301076,-0.062905915,0.10435637,-0.043837547,-0.021971134,0.04458523,0.0018279091,-0.057701293,-0.0072999327,-0.024572702,0.08904193,0.030203374,0.008077494,-0.008820603,-0.045529753,-0.042652167,-0.017548382,-0.003835511,0.05441797,-0.03380936,0.027552376,-0.04551047,0.01657414,0.04307032,-0.016747402,-0.08901949,-0.028667571,0.019104142,0.028409759,0.06314045,0.05222665,-0.048684493,0.04825682,0.022445729,0.010076037,-0.053874094,-0.06671382,0.06497912,0.006786547,-0.040926818,-0.04169512,0.07296269,-0.0135974875,-0.03340322,0.016508939,0.036661655,0.01986191,0.02294321,-0.08138774,-2.0909633e-33,0.04573576,0.0008634521,-0.04984677,0.0020775094,0.042076685,-0.030551944,-0.09347755,-0.0075437776,0.0045654345,-0.07439907,-0.030012984,-0.07157768,-0.0002822884,0.029979741,-0.0001783978,0.062788084,-0.02637165,-0.048444178,0.02649086,-0.0058682077,0.041515075,-0.011470286,-0.044825573,0.024247406,0.063411705,0.08989541,0.062921286,0.0017021757,-0.038398657,-9.918524e-05,-0.001772731,-0.02524883,-0.10736526,-0.03600594,0.12566599,0.011289345,0.007322487,-0.043811455,0.03584737,0.062141083,0.046323456,0.05156167,-0.02275077,-0.009940505,0.04192482,-0.04541661,-0.0073654433,0.13833806,0.0025346603,0.066032715,0.07350721,-0.1084212,0.004828122,-0.0070200423,-0.08964345,0.09384018,-0.036638673,-0.0021093755,-0.02064615,-0.0023378397,0.12746973,0.05372132,-0.01462162,0.04781628,0.0012534496,0.020510651,-0.09023274,-0.0441607,0.056930512,0.05152072,-0.098494366,-0.040497836,0.086303964,0.027836071,0.019543724,-0.030208504,-0.09824934,0.03830496,0.016173162,-0.013687203,-0.019908821,-0.038827814,0.036493186,-0.059893847,-0.0502183,-0.01117367,0.041817077,-0.07476176,-0.019085804,-0.015268033,0.01746647,-0.0977107,-0.010901704,0.029489823,-0.0379707,-1.6474967e-34,0.098442376,-0.093364224,0.07402163,0.00539139,-0.058685694,0.036818054,-0.063377604,0.012605882,0.039685387,0.013322218,0.03270326,0.042982135,0.04940579,-0.011446162,0.08519782,0.038077284,0.017018903,-0.05754914,-0.07883299,-0.03765602,0.012423082,-0.0022731505,0.011709541,-0.00016262894,0.07287164,0.0038187623,-0.06959061,0.10896903,0.12278455,0.011424353,0.0039653764,0.015383596,-0.017996076,-0.07149003,-0.024131,0.08599326,-0.0067556817,-0.0042060595,0.03503309,-0.018666234,0.08204301,-0.037466615,-0.019984517,0.021470902,-0.024719052,0.01874783,-0.010831943,-0.024913872,0.01107165,-0.09821937,0.06905037,-0.023007985,-0.013896147,0.042969108,-0.024567075,0.041041054,-0.023447221,-0.0010606268,-0.09247947,-0.01346997,0.039679933,-0.049385216,0.0035171702,0.027851358,0.034277294,-0.008940695,0.01920403,0.028689697,0.021649832,-0.024326164,0.106965035,0.02474517,0.039101206,0.034104805,-0.11667905,0.016861845,-0.08754959,-0.089555524,0.02248226,-0.06545603,0.03014289,-0.044341475,0.012852848,-0.02201287,-0.018785922,-0.050254032,-0.046584304,0.14466485,0.013448544,0.018274426,0.0109338015,-0.08156835,-0.013829082,0.025061268,0.0079532,-2.5214433e-08,0.08978443,-0.007367046,-0.011945379,-0.013187668,-0.028178426,0.033562712,-0.052062307,0.04666874,0.016330756,-0.030967021,-0.046984624,0.030922681,-0.05388704,0.0023799518,0.0010881078,0.017369457,-0.06794576,0.04981072,-0.01752739,0.06881323,-0.07889364,-0.03757682,-0.113602184,0.018828,0.031381756,-0.044252984,0.048802987,0.07747721,-0.00027334687,-0.06560949,-0.0029959364,0.044432733,0.03651533,0.008562216,-0.10679327,0.0150716705,-0.047217857,-0.050006133,-0.05132424,0.02525055,0.08916778,0.016836716,-0.095439136,0.014156276,-0.027075905,0.035377637,0.011072134,-0.0066294055,-0.009324722,-0.0154616255,0.04631551,-0.027879616,-0.051630966,0.016466701,-0.06806357,0.009075041,-0.012900275,-0.003672584,0.0047280374,-0.05836799,-0.019013928,0.03880363,0.17666167,0.01439993 +3.1.3.110,The enzyme has been characterized from mammals and from the bacterium Streptantibioticus cattleyicolor. In mammals it hydrolyses excess 4'-phosphopantetheine to prevent cell damage. In S. cattleyicolor it participates in the biosynthesis of the beta-lactam antibiotic thienamycin.,384,0.99999994,0.02092995,-0.021544812,-0.05682489,-0.03889101,0.05847053,0.052539412,-0.009220474,0.12466044,0.05108595,0.018420205,-0.046813972,-0.0046331454,0.051846366,0.042371396,-0.059513055,0.018634487,-0.08688981,0.006360941,0.0365114,-0.07745549,0.0890708,0.07867531,-0.019755563,0.0339875,0.024338135,-0.024235252,0.060549278,-0.0013810638,-0.012260583,-0.025564423,-0.004663381,-0.058417954,0.058198657,-0.0539192,0.014140642,0.03451737,-0.0133530935,-0.055383578,0.11316385,0.005636439,0.020053964,-0.042867657,0.012672861,-0.0148543995,-0.015345172,0.01843597,0.028568357,0.06856011,0.058385726,0.048082054,-0.03140496,-0.043997962,-0.033967033,0.09628198,0.0045676385,0.078304045,-0.05327409,-0.0050420854,-0.008594434,-0.037920084,0.0035134929,0.0076574967,0.04009201,0.03679889,-0.02603406,0.017541349,0.010647137,-0.07702065,0.036888428,-0.0572842,-0.0114482315,-0.011882236,0.068912536,0.027329586,0.031909015,0.03371667,0.0312108,0.011040036,-0.009919353,-0.053252954,0.050541144,0.008587351,-0.019205092,0.12725556,0.06876971,0.037073776,0.019548517,-0.013584283,0.042888366,0.010852497,0.048058793,-0.035288773,-0.08935166,-0.06926507,-0.053220112,-0.054020718,-0.03311819,-0.06707594,0.050861187,-0.038359556,0.002498735,-0.033026252,-0.0038979445,-0.05634743,-0.021317838,0.0019256428,-9.742059e-06,0.046345863,0.019969672,-0.035071924,0.014579228,0.009088089,0.013923775,0.028507402,0.003052064,0.12363204,0.045294747,-0.12019417,-0.099420674,-0.06110253,0.05210068,0.02630094,0.062204007,0.06515567,-0.013184172,0.008388911,-0.03052173,1.9850213e-33,-0.008226279,0.0104858605,0.025755316,-0.0898301,0.06494658,0.03355334,-0.12691227,-0.042849313,-0.0483816,-0.05952685,-0.06362263,-0.07578478,0.02096701,0.06862761,0.044956762,-0.04552606,0.011354512,0.049116086,0.020069543,0.05977674,-0.016083144,0.071699694,-0.009302904,0.03544275,0.027570631,0.016222768,0.011262078,0.07240872,0.068896346,-0.0009096064,0.011070411,-0.11328624,-0.070318885,-0.034466594,-0.027929565,-0.020796943,-0.121539585,-0.072743915,0.047585383,0.08021803,-0.062602945,0.050915174,-0.0027326562,0.004376821,0.03699465,-0.012331352,-0.00881119,0.05065828,0.008505871,-0.014617495,0.01887629,-0.024590204,0.10171764,-0.039231993,-0.07185754,0.021629747,0.0074854917,-0.022186339,-0.004522017,0.0293132,0.027191944,-0.0090946965,-0.011157462,0.008618388,0.019880882,0.027841417,-0.02469369,-0.025947658,0.029822264,0.030722834,-0.092882045,-0.023906853,-0.024206936,-0.024773337,0.0057700966,-0.021852842,0.009574681,-0.0087089725,0.04182543,-0.012394662,-0.06974491,-0.013837733,-0.030426417,0.0025396538,-0.058193825,0.01896073,0.006545956,-0.017906623,-0.029839082,-0.040622965,0.09034672,-0.106404945,-0.10260752,0.0074328682,-0.0007780209,-3.9783302e-33,0.050213072,-0.06716999,0.053028688,-0.036564868,-0.017195847,0.027795946,-0.020234507,0.066604406,0.024373066,-0.016499728,0.10727352,-0.018613582,-0.11428906,-0.0342623,0.015323351,0.034239303,0.01590811,0.10829874,-0.00037993168,-0.027471246,-0.033323396,0.049055956,0.005192961,-0.014912205,0.034902222,0.044755667,-0.04876619,0.024826935,0.01784057,0.033260904,-0.017123211,-0.0297854,-0.05912384,-0.075121075,-0.014443866,0.023424495,0.0023843409,-0.010254157,0.04873664,0.05215364,0.08787407,0.0139038665,0.048229117,0.025687274,-0.024441222,0.060261283,-0.1143319,0.044209935,-0.05403745,-0.06097609,0.029686349,0.043802466,0.05475648,-0.0028874206,0.030103283,-0.021025604,-0.0072855987,0.039526913,0.03373093,-0.009499504,-0.02577951,-0.060213484,-0.016987361,0.018728565,0.01455327,-0.040044945,-0.06154724,-0.014396573,0.06236871,-0.078930266,0.055170402,0.015137356,-0.01730495,0.09358081,-0.024713445,-0.00722535,-0.07141638,-0.060205027,0.0074121626,0.011759326,-0.025225688,-0.0536572,0.021559332,-0.008910462,-0.0033284158,-0.074858315,0.0109713115,0.17814091,0.057988744,-0.011343008,-0.014036877,0.012402902,-0.053982884,0.014268904,0.04355795,-3.753085e-08,0.024591705,-0.12751019,0.014893346,-0.066504106,-0.058939636,0.02001002,-0.019525178,0.0024304523,0.03746125,-0.033888817,-0.076309785,0.07945515,-0.041928224,-0.022593943,-0.021695204,0.036656585,-0.07348898,-0.047230586,-0.01132803,0.034922518,-0.12155265,-0.037507758,-0.18975663,0.023388684,0.031429853,-0.027290568,-0.001071589,0.062981114,-0.055635553,-0.0055078915,0.03367884,0.046476517,-0.04319014,-0.08905262,-0.05013313,0.08194882,-0.102601275,-0.010461852,0.060092855,0.038214494,-0.019421434,0.033028446,-0.019727875,0.009029087,0.016290685,0.002025062,0.041682445,0.036191553,-0.04455874,-0.051249567,-0.041590694,-0.018028958,-0.025558548,-0.013373733,-0.10392785,-0.052517734,-0.021658977,-0.059663452,0.013467336,-0.047646455,0.019822687,-0.0024020982,0.26048228,-0.02560446 +3.2.1.224,"The enzyme, characterized from the bacterium Microbacterium arabinogalactanolyticum, hydrolyses beta-D-arabinofuranosides from the non-reducing terminal of D-arabinan core structure of lipoarabinomannan and arabinogalactan of mycobacterial cell wall. cf. EC 3.2.1.55, non-reducing end alpha-L-arabinofuranosidase; EC 3.2.1.185, non-reducing end beta-L-arabinofuranosidase; EC 3.2.1.225, D-arabinan exo alpha-(1,3)/(1,5)-arabinofuranosidase (non-reducing end); and EC 3.2.1.226, D-arabinan endo alpha-(1,5)-arabinofuranosidase.",384,1.0,-0.02311852,-0.032644536,-0.048810653,-0.062075995,-0.00829324,0.025886292,-0.023664536,0.044210896,0.05959164,0.065023124,-0.014544409,-0.047374867,-0.009162532,0.0030233331,-0.0372019,0.02028794,-0.008223161,0.058956012,-0.020312453,0.027951136,0.05793654,0.060777612,-0.003276232,0.0061359857,0.042634837,0.06893565,0.005846232,0.02867353,-0.06495839,-0.07194087,0.07227561,-0.060968176,0.12133848,-0.06921218,0.092690386,0.066237055,-0.041297715,-0.025945755,0.1176341,-0.025592797,0.11313096,0.0077050007,0.08977898,-0.015300718,0.020300329,0.020073796,-0.011527271,0.020348163,0.07254919,-0.032399304,-0.037175052,-0.043910243,-0.085427366,0.039006997,0.01088416,-0.014472708,0.011167456,-0.011447089,-0.0028738314,0.068243295,0.05662854,0.03389591,0.0055053933,0.02624821,-0.07735487,-0.039819136,0.027327644,-0.085186936,0.029144369,-0.039581724,-0.00734696,0.0131909195,-0.043956734,0.033133823,0.0009798767,-0.0005045116,-0.0151906945,-0.023053132,-0.05034737,-0.011337936,-0.0024427662,-0.047640063,-0.010781928,-0.010652034,-0.050232083,-0.077775516,0.06438937,-0.0026485436,0.03116153,0.08094481,0.08157669,0.013618736,0.047399845,-0.025898017,-0.030275196,-0.032769043,0.055525348,0.016061509,-0.011115377,-0.0017737591,-0.011637642,-0.06348005,-0.014910184,-0.1033761,-0.077334195,-0.013216061,-0.0134772025,0.0349308,0.025544833,-0.010035795,-0.034239408,-0.01620375,-0.029486846,0.032111514,-0.01139105,0.0078885965,0.059267025,-0.1057876,-0.026860442,0.021428885,-0.0013969907,-0.04621455,0.13222921,0.014762615,-0.07663844,0.085106336,-0.092730105,2.390639e-33,0.03125674,-0.06520743,0.0028726445,-0.059775095,-0.020499997,-0.061000135,-0.09448585,-0.0032026398,-0.064430386,-0.023353234,-0.051684264,-0.0657353,0.0036873883,0.123594105,-0.07957548,0.06100224,0.026126787,-0.065125935,0.052733645,0.07444542,-0.005823587,0.040973566,0.011054492,0.012374162,0.0167302,0.011188832,0.003751646,-0.050355427,0.02543527,-0.014199831,-0.019263322,-0.075834975,-0.091218054,0.0011037501,0.06990817,0.053404927,-0.08226465,-0.021973517,0.016256444,-0.0127481315,-0.0066828714,-0.012440801,0.012390109,0.0052751773,0.09665771,0.046147726,-0.017623462,0.010993759,0.041685455,0.008290695,0.039595623,0.012158503,0.09412608,-0.011312214,-0.028955517,-0.015689671,-0.0055333106,0.098404005,-0.042549238,0.022874456,-0.00866309,0.052371047,-0.04128299,0.06906667,-0.0137610845,0.0013043741,-0.039727464,0.043918394,-0.0051414208,-0.0358301,-0.012810921,-0.0271802,0.10993947,0.052953627,0.06335483,0.006512303,-0.008322448,-0.0066929855,0.012541437,-0.03996784,0.0009977451,0.07183611,-0.026048249,-0.06141332,-0.10388481,0.094331555,-0.0065079783,-0.007692533,0.0017991287,-0.027080309,0.022934945,-0.06325556,-0.048716217,0.11682968,-0.045395695,-4.6489288e-33,0.06909324,-0.09325677,0.03460036,-0.050427448,0.0050780526,0.03590602,0.088295184,0.034152348,0.053562522,0.013082479,0.099999376,-0.031942807,-0.0038676723,-0.034765564,0.06699761,-0.01233972,0.03761407,-0.011188883,-0.06314233,-0.073254876,-0.038071692,0.06180039,-0.030228134,-0.07697022,0.0074332017,-0.035686202,-0.023122404,0.12877229,0.012791964,0.026064562,0.0018493724,0.009227568,-0.05435253,-0.0065233377,-0.08216121,0.048462037,-0.10114395,-0.040890127,-0.015393055,0.018122261,0.02596195,0.08367752,-0.00010401632,-0.0027092022,0.032290045,0.056576513,-0.09176135,-0.0076182964,-0.0220633,-0.069698684,-0.09772357,0.01492407,0.0238801,0.052048817,0.036607888,0.065742046,0.05503356,0.10281472,-0.008582363,-0.047954537,-0.034323655,-0.10355762,0.11215988,-0.077714205,0.038736243,0.06220265,0.05772329,0.026036685,0.004738009,-0.013116914,0.037329968,0.014664495,-0.045753658,0.04203491,0.030678503,0.06016773,-0.06701686,-0.09114049,-0.07334839,-0.057533585,0.05090251,0.022602852,-0.1013272,-0.07310865,0.07534154,-0.017344909,0.009994532,0.08811743,-0.06162923,0.06924308,0.043881867,0.008944905,-0.0749279,0.032346934,0.02536302,-4.862784e-08,0.012555448,-0.038855005,0.05429428,-0.06354033,0.029795736,0.045306075,0.021051504,0.028863057,0.050418466,-0.064625226,0.029985178,0.012067049,-0.021760954,0.036212504,-0.018997284,-0.0067753275,-0.058186043,-0.0575184,0.012203483,-0.012112543,-0.09525295,-0.028507998,-0.14773399,-0.029379766,-0.018455688,-0.08917746,0.0067598955,0.07012369,-0.07456601,0.0069130776,0.025325054,0.022237016,0.0023204812,-0.083000496,-0.0501447,2.3304918e-05,-0.03411328,-0.03866532,-0.034896802,0.035327815,0.09407161,-0.0513828,-0.060757805,0.00855114,0.032619484,-0.007864039,-0.039276987,0.07673894,-0.03549004,0.047609437,0.08851948,0.011735245,-0.07432942,-0.0027076644,-0.048136648,0.018928776,-0.021956818,-0.0013062757,-0.06928056,0.025224749,0.027661996,-0.08252565,0.078621365,-0.007237724 +3.2.1.225,"The enzyme hydrolyses alpha-D-arabinofuranosides with (1->3)- and (1->5)-linkages in D-arabinan core structure of lipoarabinomannan and arabinogalactan of mycobacterial cell wall. cf. EC 3.2.1.55, non-reducing end alpha-L-arabinofuranosidase; EC 3.2.1.224, D-arabinan exo beta-(1,2)-arabinofuranosidase (non-reducing end); and EC 3.2.1.226, D-arabinan endo alpha-(1,5)-arabinofuranosidase.",384,1.0,-0.02110177,-0.040441975,-0.06369436,-0.072207496,-0.008995774,0.012594286,-0.031752866,0.040076207,0.023112394,0.043175098,-0.005471751,-0.03449757,-0.0071239383,-0.0028289298,-0.025327114,0.02846728,-0.02675279,0.05650551,-0.047256697,0.0256482,0.038951136,0.052937426,-0.007851101,-0.00035916694,0.035909526,0.0696239,0.006744553,0.03854203,-0.05174144,-0.078668095,0.07193472,-0.07394016,0.0819697,-0.05863569,0.08039262,0.07239596,-0.028488534,-0.028303357,0.11978096,-0.03459464,0.13282795,0.019410301,0.075969264,-0.005406197,0.01139952,0.023887876,-0.024671476,0.024750624,0.07944682,-0.012973506,-0.009197604,-0.042008363,-0.07275351,0.045214076,0.009498843,-0.01696778,0.016444886,0.014907848,-0.016874406,0.082272,0.06879273,0.018493487,0.00833384,0.02335184,-0.059677456,-0.06711293,0.03691068,-0.031594303,0.008279864,-0.005971776,-0.0029605469,0.022824097,-0.04762331,0.0301702,0.0014812645,0.025513034,-0.029053498,-0.019111909,-0.07086661,-0.035515107,-0.008874845,-0.057542052,0.016805861,0.01442317,-0.054920502,-0.10035258,0.06156399,0.006470914,0.027522994,0.094412155,0.110868104,-0.012267448,0.054020576,-0.027399803,-0.020710215,-0.028578797,0.07339486,0.016870247,-0.02954861,-0.02953995,-0.01693398,-0.090235956,0.020785773,-0.09095523,-0.065080486,0.013476311,-0.054698795,0.02997624,0.023994435,-0.03310335,-0.049376756,-0.028121822,-0.007853756,0.0011894468,-0.013981167,-0.00045739653,0.03144777,-0.09767566,-0.008994838,-0.008074081,-0.0096106,-0.03434554,0.14506072,0.014124961,-0.075946905,0.0641946,-0.063856095,-2.501397e-34,0.02826192,-0.062403467,-0.022277163,-0.059269324,-0.022233851,-0.087311454,-0.0760403,0.022603445,-0.0777929,-0.0049728444,-0.049576797,-0.068912715,0.012201351,0.099964045,-0.09868316,0.09303953,0.03302963,-0.07328588,0.008597589,0.07484455,0.00978406,0.035065133,0.016262904,-0.003119179,0.0008643046,0.030823166,0.0004135623,-0.045962356,0.023952965,-0.010123649,-0.009985513,-0.066218086,-0.10010209,0.015579679,0.06621173,0.05921915,-0.050821368,-0.04859763,0.018150305,-0.015623975,0.0016708701,-0.046298593,0.028277202,-0.0077123195,0.08363742,0.0658157,-0.012748178,0.008983177,0.03464735,0.015219705,0.02433578,-0.0057385955,0.0876252,-0.00039548113,-0.031265624,-0.045518484,-0.019195018,0.09298621,-0.033586588,0.029707942,-0.0027729988,0.029760845,-0.05669036,0.06622931,-0.02399513,0.025403406,-0.050405726,0.047345348,0.021217104,-0.025046129,-0.019957406,-0.03720654,0.09321664,0.044042096,0.0676705,0.0074394755,-0.0057334485,-0.009398563,0.014969396,0.012485904,0.0065224487,0.07380836,-0.027203437,-0.034877285,-0.09825553,0.077650696,-0.029145526,-0.029219009,-0.012288216,-0.007927236,0.037522424,-0.031414665,-0.035902392,0.10933859,-0.031531677,-2.9788832e-33,0.088648036,-0.09300251,0.055316236,-0.06849544,-0.0054232934,0.06358689,0.09386303,0.059669115,0.045338508,0.020491509,0.09906638,-0.037261784,-0.037810188,-0.037485182,0.05560942,0.0010581469,0.017033856,0.003603815,-0.054286096,-0.08148694,-0.038379088,0.05018482,-0.024143154,-0.050814003,0.033519868,-0.04567942,-0.022585245,0.11179953,0.013313955,0.05247413,0.016458243,0.008201564,-0.05562417,-0.017461589,-0.08117551,0.06662201,-0.1092584,-0.045378134,-0.008801139,0.016225735,0.013258058,0.09117532,0.016316136,-0.008088921,0.050007,0.04979805,-0.12013659,-0.00077266793,-0.028002128,-0.066677116,-0.07084016,0.03424211,0.03865387,0.049562722,0.043934904,0.05619044,0.07175249,0.09456533,0.0092748385,-0.05616892,-0.046791244,-0.10329071,0.099347286,-0.07832939,0.023589656,0.06124484,0.0539859,-0.0001687612,0.036563877,-0.022770701,0.02496112,-0.0092165535,-0.03327851,0.032533143,0.017252253,0.06502902,-0.062289044,-0.10501548,-0.067123756,-0.06389387,0.03392871,0.018003976,-0.07498788,-0.084810205,0.08743912,-0.014720563,0.017498067,0.094057165,-0.07041598,0.03982701,0.04511567,6.9042426e-06,-0.09038585,0.04651262,0.021491703,-4.507962e-08,0.01412863,-0.043259397,0.056059565,-0.07608567,0.023243234,0.062769465,0.016550094,0.060394775,0.04735122,-0.0397611,0.036418535,0.013606138,-0.018669771,0.03030141,-0.026112465,-0.006303697,-0.04916079,-0.049998365,0.007659925,-0.012307511,-0.10419832,-0.03628469,-0.14107832,-0.0242357,-0.006359196,-0.075512126,0.0059460974,0.07914963,-0.03164305,0.006814363,0.030726645,0.005618605,-0.0018689928,-0.0711308,-0.01828279,0.01252652,-0.062512115,-0.059178375,-0.046170954,0.019897588,0.098285,-0.051491056,-0.059993647,0.0099927625,0.04415025,-0.011701127,-0.036941633,0.07693245,-0.052362107,0.030690908,0.09932329,0.017718712,-0.06666886,-0.017514475,-0.03009276,0.006030571,-0.011425017,-0.007857251,-0.084785014,0.03044289,0.005131607,-0.06539106,0.07889857,-0.011333973 +3.2.1.226,"The enzyme hydrolyses alpha-(1->5)-D-arabinofuranoside bonds in D-arabinan core structure of lipoarabinomannan and arabinogalactan of mycobacterial cell wall. cf. EC 3.2.1.224, D-arabinan exo beta-(1,2)-arabinofuranosidase (non-reducing end) and EC 3.2.1.225, D-arabinan exo alpha-(1,3)/(1,5)-arabinofuranosidase (non-reducing end).",384,0.99999994,-0.025014088,-0.03442961,-0.07272324,-0.0626152,-0.028213935,-0.014219371,-0.026998384,0.050345726,0.050002165,0.042879064,-0.012831911,-0.025894294,-0.0048460634,0.0071468246,-0.01245024,0.019553887,-0.022255415,0.04724004,-0.041319888,0.056365106,0.045729972,0.042913474,0.00066656625,-0.013018291,0.037817154,0.112608686,0.028747078,0.02832462,-0.050665762,-0.055498533,0.08027563,-0.09121682,0.103740126,-0.0435789,0.094117075,0.07618931,-0.02721,-0.02914071,0.11386776,-0.045110174,0.11987401,0.022909494,0.079836085,-0.015263987,0.017019946,0.0053725466,-0.038868885,0.021659747,0.0734726,-0.02972605,0.011079082,-0.033705413,-0.09256583,0.037664045,0.006822082,-0.012098394,-0.0030170055,0.025832662,-0.023261094,0.07929374,0.086760946,0.038342677,0.022769377,0.034559466,-0.07913138,-0.059693556,0.0575545,-0.009359248,0.01248119,-0.016598435,0.007939266,0.029496776,-0.046510655,-0.0037751216,0.024186462,0.01489272,-0.030599082,-0.02556116,-0.05767016,-0.038465843,-0.0040890337,-0.07003527,0.014617199,0.022373853,-0.045785975,-0.10094349,0.07340115,-0.0045519043,0.027309777,0.09794072,0.092927195,0.0020383594,0.049409017,-0.024998855,-0.061841346,-0.029774949,0.067459725,0.03179795,-0.05352567,-0.019262258,-0.0034048138,-0.066641554,-0.014714597,-0.08457652,-0.065129586,0.0052137766,-0.034561593,0.029087044,0.032192923,-0.020947363,-0.053087525,-0.01805842,-0.009104265,0.008018416,-0.016046492,0.0109095145,0.021374252,-0.10117069,-0.016988214,-0.011858735,-0.005409566,-0.04667669,0.11485757,0.016049337,-0.08123403,0.03235239,-0.055765547,-6.4446143e-34,0.032089047,-0.06938455,-0.0049682236,-0.05873101,-0.04057338,-0.08480178,-0.07713456,0.012408441,-0.09031479,-0.020676382,-0.052718617,-0.06970458,0.03447935,0.091326505,-0.117859885,0.08555841,0.0025374496,-0.07687231,0.048843738,0.10801531,0.001175342,0.05344288,0.02727737,0.014664417,-0.004822776,0.0189642,-0.0069950037,-0.030203143,0.028297711,-0.0018448292,-0.013820658,-0.053950924,-0.103788055,-0.010094733,0.06926568,0.07239003,-0.055315472,-0.032855876,0.017940218,-0.02579471,-0.0053683734,-0.051376842,0.020481616,-0.0039845514,0.07751527,0.072655395,-0.010755264,0.016775694,0.027909908,0.0123266615,0.03284568,-0.019730762,0.054158445,0.014467015,-0.048069406,-0.021446547,-0.0033514593,0.07935025,-0.05574986,0.031914555,0.004326733,0.010850931,-0.057635695,0.057888635,-0.04785918,0.03379778,-0.037796292,0.052663956,0.00987675,-0.019206936,-0.024280462,-0.02812619,0.09126188,0.033816602,0.062229495,0.01725808,0.008343826,-0.0044430043,0.006114153,0.022660444,0.02129319,0.06555841,-0.0133754015,-0.050626196,-0.09610834,0.08186742,-0.014341859,-0.025373595,0.017604219,0.0016663726,0.031773932,-0.053109303,-0.019872988,0.08162358,-0.029183509,-2.9475795e-33,0.09224542,-0.10537334,0.04053309,-0.06780786,0.0017167578,0.046693,0.08472736,0.051640477,0.04401846,0.013414033,0.11344776,-0.043434743,-0.043825563,-0.021984076,0.043090273,-0.004706921,0.00849171,-0.013814052,-0.04459513,-0.07259628,-0.04991692,0.049049225,-0.015140074,-0.040558305,0.027115647,-0.032396838,-0.051564787,0.09308978,0.02732049,0.038341105,0.0021062861,-0.0033209764,-0.061846476,-0.0059590405,-0.08783193,0.08023831,-0.1007231,-0.05909624,-0.022490766,0.007513167,0.0017693052,0.089386016,0.011151248,-0.004286923,0.031992596,0.054844104,-0.11158032,0.010616207,-0.043028302,-0.059515696,-0.08064594,0.039452635,0.03782844,0.041601304,0.051269736,0.052810617,0.070881814,0.0835503,0.023051636,-0.048505615,-0.04733908,-0.098762035,0.0790757,-0.07962641,0.008915615,0.04595988,0.0628917,0.008151964,0.026661823,-0.039317027,0.03735531,0.017953377,-0.04286008,0.042428315,0.024669943,0.047760945,-0.054126527,-0.11905791,-0.07250426,-0.055896636,0.048643123,0.025856659,-0.08122343,-0.103063315,0.06267358,0.00086651323,0.027286552,0.10210084,-0.074064486,0.036330905,0.030336963,0.023886878,-0.06986146,0.03855064,0.025688663,-4.4203013e-08,-0.0012785548,-0.029671157,0.04359567,-0.08076259,0.014795049,0.067751564,0.011131601,0.03727687,0.054690555,-0.03993329,0.055598892,0.016210133,-0.031078957,0.01484561,-0.045949195,0.0046128146,-0.058786377,-0.07450536,0.014533518,-0.012501939,-0.10265069,-0.026355963,-0.14793839,-0.03254237,-0.0064478405,-0.08107095,0.0038023305,0.063068666,-0.043912753,0.016127653,0.035034887,0.0019510525,0.016805103,-0.06431377,-0.011046192,0.0015477512,-0.046411164,-0.04078611,-0.035271503,0.027891306,0.08103453,-0.051397886,-0.05558415,0.006383436,0.040999632,0.01646572,-0.040634025,0.08654212,-0.047183707,0.050421838,0.0813377,0.015619341,-0.09452858,-0.0143203875,-0.04158358,0.024314683,-0.031138,-0.0039934185,-0.065692455,0.011756654,-0.016100366,-0.073901385,0.06692293,-0.0025249596 +3.5.3.27,"The enzyme, characterized from different cyanobacterial species, is highly specific to arginine and does not require a metal cofactor. The enzyme from Nostoc is bifunctional, and also catalyses the activity of EC 4.3.1.12, ornithine cyclodeaminase.",384,1.0,-0.10382953,-0.030624675,-0.09250923,-0.0066870474,0.05856098,0.018996125,-0.044091895,0.013085367,-0.012966533,-0.00072416256,-0.011370113,-0.10356199,-0.035863034,0.030786235,-0.052344307,0.03475092,-0.07139039,0.0059848255,0.0638527,0.013929697,0.057551123,0.062413815,-0.0096495375,-0.039480448,0.023489282,0.03312773,-0.04837161,-0.010542013,-0.005887544,-0.05950454,0.025072822,-0.021256115,0.032194186,-0.050100047,0.108392395,0.0028137993,-0.037402608,-0.07902214,-0.03380635,0.0035010267,0.04439403,0.05644511,-0.037571356,0.017087292,0.011581268,-0.013445864,0.06037878,-0.04957462,-0.010945736,0.0006361587,0.007162653,-0.043264255,-0.014589101,0.0031842752,-0.02899881,0.063577645,-0.14166163,-0.09865211,0.044566892,0.029532231,0.07738415,-0.0059293616,-0.025912277,0.017383227,0.023339856,-0.017915273,-0.0034072339,-0.08288606,0.089303724,0.0015112418,0.010567438,-0.08945658,-0.07156641,0.040442783,-0.0055141402,0.055500504,0.071859024,-0.049414344,0.027668295,-0.036554817,-0.005711113,0.022467518,0.025975395,0.04735579,0.06832324,-0.022132868,0.018372701,0.025428414,-0.035414334,0.043181915,0.112591885,0.029088719,0.0108834645,-0.09196208,0.0033901727,0.010953518,0.051007397,0.10180774,0.016241593,0.0012272253,0.027767416,0.050005775,-0.035753265,-0.068184264,-0.008578604,0.035204206,0.078969024,0.043070193,0.046629854,0.039324068,-0.094857164,-0.014243052,-0.036581255,-0.04327172,-0.040634114,0.06763868,0.05510495,-0.06256957,-0.024971098,0.020933188,-0.034055166,-0.061194867,0.042844187,0.09942586,0.0012593722,0.10855264,-0.1014339,1.7441532e-33,0.061123032,0.0015184927,0.06945565,-0.09495232,-0.020876218,0.031022007,-0.03523374,0.05393548,0.024144394,-0.08445505,-0.09563514,0.010770305,0.08387383,-0.023765462,-0.05028053,-0.0300292,-0.054804552,-0.052629437,0.05035528,-0.01426048,-0.018295472,0.03790967,-0.04264968,0.06455941,0.024327297,-0.018524416,0.0036814774,-0.03166277,0.005229109,0.0012298807,-0.03809134,-0.09168293,-0.035722896,-0.01954357,0.0756085,0.005683594,0.042656757,-0.015215815,0.00676502,0.052276354,-0.112719655,-0.012522567,0.009671886,-0.017455554,0.039746977,-0.0725409,-0.10400274,0.1510145,-0.03255982,0.044320323,0.05291306,-0.026745956,0.037485674,0.032895952,-0.036454972,0.055951856,-0.017898975,0.026177295,0.062073335,-0.008463576,0.025576271,0.06236119,-0.0070620766,0.04326626,0.039129235,0.051112246,-0.05795284,-0.026401095,-0.019063,0.052134756,-0.08826053,0.002407731,0.03327168,0.022741757,0.045447394,-0.005047673,-0.0809485,0.009526921,0.07795499,0.018556543,-0.019913238,-0.049361367,0.06492685,-0.03390317,-0.009305269,-0.07719324,-0.00755406,-0.031670477,0.017750667,0.039788768,0.053605847,-0.038442962,-0.056948148,0.024404138,-0.03351472,-1.840282e-33,0.11974403,-0.075590394,0.045334045,-0.02533465,-0.0318014,0.07584365,-0.05715033,-0.04610775,0.02349451,-0.009399416,0.10163884,-0.03830225,0.10242136,-0.067757644,0.06940924,-0.028293576,-0.065321065,0.07648696,0.022227267,0.05454501,-0.059941582,-0.022423157,-0.02192611,-0.020789571,0.020671295,0.010192688,-0.061009254,-0.007002099,0.045376517,0.033148427,-0.06232524,0.024894357,-0.010351815,-0.0681146,-0.014216574,0.046044998,0.039424654,-0.004552835,-0.00563295,-0.031823497,-0.0062536155,0.007921355,-0.030585859,0.09388161,0.03698543,0.03994461,-0.030192273,0.037614856,-0.030491132,-0.054954406,0.06450421,-0.0014900635,0.0034242906,0.011965694,0.016247971,0.08796529,0.04072882,-0.025777292,-0.01944674,0.01444192,0.06970669,-0.06372574,0.01752067,-0.047252942,0.07271207,0.03339557,-0.026358375,0.14398871,-0.0426079,-0.04576703,0.013588916,-0.01171503,0.008863197,0.013057048,-0.021353288,-0.018470319,0.025259253,-0.0793877,0.0057056434,-0.058298398,0.018901315,0.027337873,0.0012975235,-0.030414699,-0.031866547,0.029627454,0.07048787,0.13130979,-0.011857376,0.035018265,-0.081460394,-0.00555432,-0.053006135,0.13887925,0.04527663,-3.4731485e-08,0.01953851,0.004716368,0.03424542,-0.042280998,0.01080945,0.07364281,0.020425465,-0.05490557,0.020356683,-0.02162862,0.0883209,0.06317551,-0.039066773,-0.044904415,0.05431797,0.012943015,-0.0066226055,-0.028217802,0.004305421,0.043761544,-0.06489294,0.024821587,-0.071556,0.0034631023,-0.045292106,-0.068161026,0.08283205,0.12292336,-0.0540492,-0.013865239,-0.023105947,-0.009001231,-0.045120936,-0.0064673815,-0.0770936,0.011834856,-0.00752647,-0.08295506,0.011261947,-0.021961,-0.10692237,0.047947153,-0.10225101,0.0025076033,-0.0014913608,-0.026481805,0.017014269,-0.008664648,0.0027079103,-0.014842428,-0.063202634,-0.06774251,0.017910948,-0.07840556,-0.020930242,0.0060778596,-0.0083845705,-0.054496884,-0.036205538,-0.07337687,0.021013357,-0.044848282,0.17091247,0.053392496 +3.5.99.12,"The enzyme, present in mammalian brains, forms the catechol isoquinoline (R)-salsolinol. This compound can be metabolized to (R)-N-methylsalsolinol, a 1-methyl-4-phenylpyridinium-like neurotoxin that impairs the function of dopaminergic neurons, causing the clinical symptoms of Parkinson's disease.",384,0.99999994,0.036237583,-0.07054999,-0.060402427,0.06194066,0.073434345,0.054148067,-0.040279493,0.075439505,0.065692686,-0.024877334,0.02158792,0.045828436,-0.04310985,0.0054582017,-0.033744294,0.09792489,-0.077164784,0.03960063,0.038193498,0.022970729,-0.00026715524,-0.0018053874,0.0016579197,0.060096625,-0.038137145,0.0732294,0.031674206,0.007705119,-0.037599504,-0.0044355504,0.0857157,-0.06254804,0.0005839046,0.008210172,-0.008333806,0.037644364,-0.06878759,-0.05100439,0.0012426765,0.035269942,0.0044896514,-0.06799675,-0.057368815,0.058790766,0.026805991,-0.07284133,0.024519362,-0.03306819,0.09410218,-0.010611017,0.005695398,-0.061081756,0.007907097,0.07878655,-0.024592083,0.027019229,-0.07675155,-0.0015851969,-0.017298087,0.055140965,-0.052987956,0.08730828,-0.003591627,-0.055508565,0.050940342,0.069717415,-0.04029204,-0.062763296,0.060868774,-0.005223399,0.01935455,-0.099377975,0.010424852,-0.021429084,-0.004264433,0.033901244,-0.030075919,0.017863797,0.065685466,-0.06446201,0.0120505,0.08365279,-0.016485376,0.059720065,0.079494916,0.015294364,-0.008650141,0.010856696,0.04783456,0.018821348,-0.022837926,-0.04642864,-0.059966706,-0.03467633,-0.11172377,-0.048704963,-0.0068696165,0.056248497,0.0009051714,0.031334676,0.032371026,0.059970997,-0.12689632,-0.107206374,-0.0532969,0.06971254,0.047992468,-0.046874948,-0.009098422,-0.04919535,-0.025628347,-0.005126015,-0.05791908,0.03448429,0.021662017,0.015904551,0.00641863,0.033100143,-0.056088276,-0.012482272,-0.03468159,-0.0008514492,0.0011182275,-0.03817194,-0.016758075,-0.054275684,-0.056121845,1.2893672e-33,0.046152018,0.030033093,-0.03247805,-0.01211762,0.03972394,0.008458585,0.010740509,0.059880048,0.042391792,-0.021550588,-0.07696402,-0.10298515,-0.05042885,0.030457344,-0.015519053,-0.014609128,-0.058562264,-0.027983986,0.091783285,-0.03594284,-0.019842649,0.050906226,0.010085944,9.192626e-05,-0.037047125,-0.008915834,-0.11415947,0.040575847,0.08746629,0.0037660375,0.031085182,-0.015840443,-0.10713114,0.015721446,-0.08429617,0.0013304144,-0.04097031,0.015496792,0.0016372614,0.10477466,0.011619367,0.040284082,-0.027772978,-0.045852337,0.029266784,0.031127693,-0.03499629,0.07417303,0.10115995,-0.0309173,0.024229217,-0.031393357,0.062183913,0.0014783796,-0.029788733,-0.05964801,-0.0464452,-0.055495866,0.045124497,0.033593934,0.054248188,0.014876337,0.030871809,-0.0042154742,0.06096998,0.008373224,-0.015005288,8.29295e-05,0.024124064,0.010112531,0.028076092,-0.020297311,-0.023856647,0.014161601,0.009491185,-0.05296237,-0.057234302,0.007605978,-0.0066727535,-0.041070197,-0.093027174,-0.036973167,-0.012706051,0.055165492,0.0074216262,0.104770966,0.013466334,-0.012910242,-0.06107478,0.04122255,-0.0065583666,-0.04099655,-0.063970126,-0.018563377,-0.004828921,-1.3865548e-33,-0.040130917,-0.0733279,-0.008522903,-0.047346924,-0.069690265,0.10256714,-0.019079708,-0.03746621,-0.030250147,0.015397372,0.07279841,-0.027006399,0.0020281253,0.04190239,0.033823848,-0.03451978,-0.06516221,0.09488051,0.013965906,-0.006229111,-0.02308528,0.056790754,-0.05373175,0.079576895,0.06145586,0.035225794,0.0023552326,-0.025498785,0.116633244,0.06265287,0.045849804,0.06899419,-0.03155431,-0.0529509,0.043876916,0.04695871,-0.004242836,-0.0294194,-0.0665776,-0.008502259,0.0141877,0.05816735,-0.01437564,0.009489333,0.019981664,0.013717152,-0.07964876,-0.06560876,-0.01426377,-0.009290143,0.07859044,-0.028634729,-0.024852477,-0.06645731,-0.01346878,0.019186474,-0.08295497,-0.07207691,0.053847913,-0.075481996,-0.07143196,-0.008186259,-0.057902936,-0.029258756,0.07317099,0.036546133,0.05498869,0.06135073,0.028847612,-0.039580688,0.09156709,0.009241302,0.084954835,0.12070605,-0.07124994,0.014905709,0.08055138,-0.0045929695,0.05954905,-0.046780396,0.018742377,-0.06726343,0.011829334,-0.04908817,-0.09363701,-0.025331484,0.014962408,0.113522574,0.0038603502,0.06350618,0.08624606,0.016451772,-0.04951528,0.02452582,0.08658752,-3.9960195e-08,0.04675584,-0.08307696,0.015047126,-0.006074561,-0.02066074,0.011323294,0.06134936,-0.047037184,-0.072325915,0.013403338,0.04406936,0.023538586,0.02870462,-0.006816933,-0.026704866,0.0711893,0.033739164,0.15388732,0.009392395,-0.0119983,-0.08247431,0.027050747,-0.042132095,-0.0458135,0.08419924,-0.14848922,0.054858573,0.09571288,-0.0024598849,-0.03942133,0.01337094,0.0041426206,0.049094312,-0.035670284,0.003956617,0.030036343,0.0028510974,-0.045779675,0.00080808066,-0.04201755,-0.06732564,-0.015520573,0.0029330566,-0.007994971,0.0048247804,-0.05620964,0.026554124,0.020213049,0.013846309,-0.019098546,0.0028021852,0.04574476,0.056650616,-0.06981949,-0.09968994,0.020567985,-0.060987733,-0.049144402,-0.04202911,-0.18901303,0.034240775,0.03046363,0.111413926,-0.026123628 +3.5.99.13,"Catalyses a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine [4,5]. Involved in the biosynthesis of the monoterpenoid indole alkaloids.",384,1.0,-0.0060080285,-0.042499438,-0.05706718,0.00082892826,-0.062270507,0.046716686,-0.006481211,0.0031162156,0.07832359,0.008515246,0.08014874,-0.11186657,-0.01570162,0.026863685,-0.028062578,0.059427794,-0.010752476,-0.0086276755,0.03686303,-0.011799693,-0.043585997,0.009673329,0.0045997417,-0.0013866305,0.01205736,0.0356655,-0.015127162,-0.005050467,0.013961296,0.0034586927,0.019042937,-0.031026771,-0.099483564,-0.013432215,0.00090602046,0.0013487623,-0.09527382,0.017719077,0.15441208,0.00340435,0.00016970454,-0.03418037,-0.03547262,-0.03263369,-0.02499032,-0.05142003,-0.025190333,0.024022674,0.031160863,-0.062232044,0.013519658,-0.040424585,-0.03736264,0.015257799,0.066713825,-0.038454447,-0.0109446505,0.041134726,-0.019922307,0.060066737,0.047456633,0.046602774,-0.04850489,-0.026406007,-0.020621335,-0.06613921,-0.020764368,0.0005859432,0.065931015,-0.016949208,-0.004967065,-0.08399013,-0.047287237,-0.0025315061,-0.034435667,0.013474669,-0.027072338,0.038876694,-0.06520989,-0.11095618,0.023650985,0.0075588683,0.03247802,0.14011772,-0.008535684,0.02307389,0.047055535,0.10620819,0.070307404,0.014330413,0.05290058,0.013259073,-0.024042517,-0.030482886,-0.04259426,0.043834403,0.008595356,0.02079316,0.011241206,0.012041084,0.0615774,-0.01371516,-0.14677216,-0.10228695,0.0026663127,0.011167364,0.0058718706,-0.0016645552,0.07622706,-0.07083755,-0.021458212,-0.032628693,0.03529536,0.052641127,-0.060762912,0.019295081,-0.005234247,-0.024684556,-0.008505226,0.021555524,0.040503833,0.08545282,-0.006019374,0.08408786,-0.008339075,-0.012774765,-0.005034718,1.6418095e-33,0.08892815,0.010786862,0.023856025,0.018557008,0.0071175303,0.020015895,-0.07215166,-0.00095337426,-0.044129,-0.05631577,-0.1349091,-0.07272937,0.016938517,0.002325927,0.035362232,-0.029113282,-0.124385566,-0.03537141,0.06980927,-0.03159067,-0.11429433,0.005744059,-0.060484804,0.03125078,-0.054663118,0.088340335,0.0008183238,0.017274085,-0.028388714,-0.021782622,-0.05394749,-0.0025681027,-0.06329537,-0.013239076,-0.03608089,-0.061621193,0.028877262,0.003997414,-0.06994739,0.04328035,0.035266902,0.11249471,-0.04157686,0.052331563,0.08942851,0.05148748,-0.048103593,0.15003589,0.07901077,0.0610732,-0.015734099,-0.077256225,0.06517847,0.037095815,-0.09415537,0.05111806,-0.021115018,-0.009936455,0.011637124,0.03665214,-0.048314027,-0.013366999,-0.0003875454,-0.02317008,-0.052428655,0.04436374,0.0061108507,-0.011747489,0.0034804353,0.028044429,-0.06863934,0.071805805,0.05310191,0.0017157934,0.053444136,0.030511254,0.041707683,-0.022504147,-0.026012206,-0.0054032793,-0.009949898,-0.0210334,0.012309557,-0.051993337,-0.014303606,-0.028112164,-0.042525098,-0.038107794,-0.019162713,0.093650475,-0.029675813,-0.024211831,-0.13335443,0.040742233,-0.07162283,-2.884397e-33,0.038612925,-0.085154355,-0.0145936385,-0.08621195,-0.07465633,0.023807516,-0.0788984,-0.03181429,0.029926315,0.059406895,0.06426408,0.0030323507,0.12756746,0.026199745,-0.043371968,-0.062443025,-0.0075889276,0.10181709,0.029577497,0.0022280265,-0.0012360851,0.04054052,-0.083990805,0.053507764,0.04853284,0.056474768,-0.019560745,0.01945874,0.037896242,0.06260026,0.125743,-0.11742156,-0.06772445,0.0063139386,0.07695509,0.081003085,0.042330656,0.06538244,0.024400117,0.09451056,0.0011210617,0.030376704,0.043661952,0.07870507,0.09022271,0.006980051,-0.09095124,-0.016843723,-0.102344535,-0.042200975,0.05576786,-0.04420318,0.015813772,-0.009603528,-0.002926504,-0.019545093,0.029316105,-0.065595955,0.047123924,-0.03233032,-0.031902865,-0.04766396,0.0084957415,-0.04401395,-0.05002588,0.015640736,-0.004885689,0.059916522,0.06968947,-0.036785096,0.06309304,-0.05483455,0.013938249,0.028199084,-0.013940882,-0.029315626,0.03376103,-0.07399677,0.026442606,-0.010030465,-0.0013109472,0.04846324,0.0710715,-0.07563981,-0.02484024,0.03470477,0.029872304,0.10601262,0.05064799,-0.009285421,0.031853735,0.0449063,0.069219574,0.06440057,0.06382044,-2.982259e-08,0.0560299,-0.017739296,0.022158977,0.07476854,-0.015790788,0.017516213,-0.008536456,-0.017278584,-0.015244284,-0.072316475,-0.010851934,-0.032442354,-0.033291165,0.064488694,0.030282894,0.039209712,0.013964949,-0.025456088,-0.0032189738,-0.03432505,-0.088391416,-0.007751797,-0.020532906,-0.035125367,-0.04170857,-0.10449999,-0.024654675,0.004807354,0.022865469,-0.07439475,0.031238738,0.036303915,-0.009273088,0.018640546,-0.044119086,0.041589428,-0.051141877,0.0018108892,0.073576435,-0.005863015,-0.0705728,-0.12301646,-0.026012287,-0.0163127,-0.02530311,-0.02602682,0.05061744,-0.033274837,0.032362573,-0.0024126326,0.044598505,-0.010670453,0.03920621,0.013974563,-0.11103262,-0.017988686,-0.049910188,-0.0015507753,0.0017811254,-0.11300828,-0.02859616,0.065309316,0.07265607,0.041925937 +3.5.99.14,"The reaction makes a six-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates. The product is the precursor of the benzylisoquinoline alkaloids in plants. The enzyme, formerly known as (S)-norlaudanosoline synthase, will also catalyse the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants.",384,1.0,-0.07133047,-0.043702226,-0.090733506,-0.029318027,-0.025866538,0.07251534,-0.09941214,0.031806458,0.12432344,-0.008682174,0.034851376,-0.030534714,0.016900547,-0.06360879,-0.10627728,0.12513506,-0.11959063,0.0074367304,-0.035436917,-0.034673315,-0.039136823,0.05609286,0.044241324,-0.017888108,0.09424231,-0.023009505,-0.0039341594,0.007917903,0.02324078,-0.03731533,0.027987253,0.022725932,0.0074780295,-0.01021833,0.014134198,0.005366473,-0.042626172,-0.005670994,0.03330444,0.060026325,-0.02805387,-0.009744932,-0.063405424,-0.0051259166,-0.019842135,-0.005907341,-0.03223438,0.040089335,0.052825924,-0.03441357,-0.007429977,-0.03989473,-0.053908385,0.028591836,-0.024818905,-0.0044066096,-0.062037736,0.078844875,-0.041732937,0.100309245,0.08926515,0.02772606,0.019616567,-0.012577207,0.009508233,0.019417956,-0.034180257,-0.018394979,0.09681622,-0.087256685,-0.011792609,-0.100267634,0.010545577,0.007662824,-0.042594083,0.05204611,-0.049090646,0.030220635,0.027056843,-0.07037797,0.0070355744,0.015851159,-0.0009153425,0.060383912,-0.015599066,0.023022782,0.003317706,0.08325853,0.089893535,0.023766354,-0.012993241,-0.037706755,-0.114711314,-0.05559719,-0.07133479,0.06263695,0.05217289,0.021180585,0.0062969886,-0.0026859308,0.08383905,0.020692945,-0.09478671,-0.09594439,-0.0056301486,0.071492404,-0.019932548,0.003915036,-0.024754317,-0.047851223,0.009778213,-0.04444591,0.016546056,0.007768768,-0.003932889,0.038715787,0.064804524,-0.004623269,-0.045623075,0.0048826323,-0.014450091,0.029517552,0.024947334,0.057457946,-0.043809608,0.06195246,-0.083765425,1.9097695e-33,0.059750374,0.098342605,0.011933858,0.03695069,0.005678039,-0.035634164,-0.06884607,0.037316408,-0.09421325,-0.080316596,-0.07916942,-0.07737262,0.022553705,-0.03575545,0.065579265,-0.041502573,0.003966292,-0.050696082,0.047848906,-0.06475934,-0.06108695,0.046849128,-0.061420016,0.0011066075,0.0037052494,0.052928027,0.015178507,0.014281737,0.0013685346,-0.048156314,-0.031137444,-0.04192248,-0.060070693,-0.0041788886,-0.011900537,0.039143387,-0.023846399,0.0011620042,-0.0094464375,0.036691833,0.067820944,0.049140804,0.007693041,-0.0049738577,0.061634243,0.0065871854,-0.07389084,0.08509323,0.047870934,0.040968884,-0.007812254,0.017133161,0.1479987,0.011975563,-0.059303604,0.013350923,-0.009655228,-0.028585784,0.03237995,0.040924013,-0.0470193,0.0017754374,-0.033991825,0.042206258,0.014371897,-0.025874106,-0.051304225,-0.020031508,-0.023528703,0.049310606,-0.049921304,-0.035975467,0.014832381,0.037843782,0.014999474,-0.02539368,-0.0992685,0.0010590659,0.0325624,-0.035057515,0.03377783,0.00028040624,0.041456014,-0.015874404,-0.02068984,0.024289716,-0.030971805,-0.044834178,-0.021696756,0.09029082,0.03938561,-0.026834087,-0.057828043,0.02449168,0.036283754,-2.7955107e-33,0.058706056,-0.09538585,0.022188175,-0.048562158,-0.0065385206,0.059820563,-0.032922167,-0.05274829,0.006390831,0.04754259,0.055356853,0.007959302,0.019510195,-0.021666652,0.0064381356,-0.079196595,0.06365369,0.15086642,0.07621973,-0.023458831,-0.04701345,0.03841319,-0.1006226,0.0440798,-0.009397888,0.03542249,0.063601464,-0.051438592,0.0032455365,0.07313593,0.037580032,-0.033295672,-0.02881898,-0.02368553,0.06553405,0.0762057,-0.005635968,-0.036099166,-0.016288696,0.0147478385,-0.03603792,0.044571884,0.025852077,0.005101364,0.068585694,-0.012681373,-0.039765734,0.05951071,-0.077710606,-0.007941577,0.095895246,-0.022530489,-0.029743847,-0.014205259,0.047361925,0.0416492,0.026611852,-0.078688286,0.011896939,-0.04363886,-0.043264944,-0.070933394,-0.03166398,-0.061688542,-0.0035143492,0.08668229,0.009897606,0.12661232,0.046835426,-0.060144953,0.06902753,0.039778113,-0.017628616,0.036692962,-0.060683332,-0.032747347,0.06807564,-0.05590192,0.017295063,-0.09060518,-0.022204774,-0.020461548,0.06170152,-0.02122113,-0.022519697,-0.05561459,0.04304527,0.13798954,0.009349034,0.08547908,0.045570415,0.039336085,-0.07957824,0.082685165,0.10074234,-4.4746862e-08,0.06903327,-0.060528167,0.04187643,-0.02056495,-0.0099232085,-0.005575207,0.0760445,0.005659769,0.020260267,-0.07028751,-0.029264038,0.049847193,-0.030919973,0.01634591,0.019238228,-0.024015566,0.02226691,0.062008895,-0.04866156,-0.0005714928,-0.042050067,0.042409524,-0.077235006,-0.036731556,0.015162546,-0.107878566,-0.0012783919,0.08039553,0.030918397,-0.012999503,0.051549308,0.022797521,-0.023669286,-0.05547721,-0.02644511,-0.052784193,0.02708475,-0.0454529,0.032660812,-0.04301772,-0.039732024,-0.03798913,-0.03194136,0.010371289,0.01982453,-0.04072659,-0.04498495,-0.0023377049,0.011596959,0.029893395,0.0058191675,0.051275596,0.054918263,-0.11660493,-0.10124033,-0.028190142,0.003896141,-0.054641623,0.0077165137,-0.12760074,-0.024507647,0.020892074,0.18733369,0.00028487862 +3.5.99.15,"The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 3.5.99.16, deacetylipecoside synthase. The product is rapidly converted to demethylisoalangiside.",384,0.99999994,-0.027002519,-0.05998487,-0.04144086,-0.041637793,0.01814045,0.063721985,-0.058366805,0.0011019902,-0.012278924,0.014099756,0.061142232,-0.07691612,-0.035536006,-0.08545708,0.03111187,0.06881211,-0.008648762,0.07914188,-0.08883525,-0.070502475,0.041000176,0.01607011,0.01663271,0.0624982,0.05018583,0.018911857,0.037714846,0.04025888,-0.03229297,-0.11259277,-0.023639794,-0.023385987,0.05739899,-0.077968225,0.08136951,0.050123867,-0.12269449,-0.10012623,0.1241301,-0.0617651,0.10200424,-0.009560709,-0.04728665,-0.029083641,-0.019814301,-0.066763245,-0.048141267,0.06566437,0.08293072,8.5140404e-05,-0.03165614,-0.050507892,-0.01946741,-0.08167454,-0.045561384,0.018386813,0.013103914,0.012592029,-0.007420518,0.040626638,0.07402024,0.042645577,-0.015560551,-0.014601399,-0.037062004,0.037289098,0.033085875,-0.081203684,0.06954369,0.0047015473,0.011625154,-0.04070973,-0.07940891,0.07083112,0.020354323,0.02396852,0.0127317235,0.0074697905,-0.014436792,-0.023398595,0.0356191,0.004286458,0.026342398,0.0058951546,0.0024926933,-0.01829276,0.043771315,-0.016921744,0.011554128,0.052925404,0.06982679,-0.033954754,0.019277776,-0.06640998,0.0011787014,0.026158668,-0.00045857564,0.058654748,-0.011849936,-0.019874487,-0.012678487,0.027220242,-0.03294945,-0.05103094,-0.052521616,-0.026852237,0.013674891,-0.040061068,0.03846272,-0.02808456,-0.032993406,-0.10907377,0.06427372,0.04855208,-0.055197388,0.053751647,0.060288306,-0.033295847,0.012888289,0.0121111525,0.07395734,-0.02988701,0.09690792,0.03316063,-0.04361778,0.04788558,-0.08670138,3.6830743e-33,0.07833248,-0.01621495,0.033378664,0.049072433,0.016823372,0.004890846,-0.07924324,0.015490856,-0.07503607,-0.03306897,-0.11100994,-0.016512405,-0.025239993,0.042483892,0.013058221,0.036469296,-0.031680204,0.0692772,0.06619582,0.027553994,-0.0022693202,0.04412349,-0.069886185,-0.024049008,-0.0642437,0.023057899,0.023661047,-0.021521533,0.086366415,-0.0034093764,0.0063522,-0.039410826,-0.09014153,0.022394422,-0.025425738,-0.017627368,0.009625342,-0.048508912,0.04526736,0.05691143,-0.013377789,0.08717853,0.027080566,-0.051079094,0.032671038,-0.0041205822,0.014267971,0.0015528469,0.12501772,0.0048375526,0.032498963,0.04316636,0.17961547,-0.026208991,0.042301457,-0.007868416,0.012814187,0.11093014,0.06404036,0.04568164,0.066280484,0.08975775,0.06966604,-0.02467291,0.055885427,0.021334475,-0.07308505,-0.022013126,-0.017663782,0.005500651,-0.038991366,-0.031209093,-0.013962877,0.038874112,0.055291835,-0.05779055,-0.092175536,-0.010071218,-0.0107884295,-0.045760475,-0.050646607,0.037640672,-0.046221547,-0.017818036,-0.006699521,0.018370641,-0.05113873,0.05499288,0.037879746,0.036208987,0.053439476,0.01465664,-0.12240203,0.051879335,0.062140692,-3.8321582e-33,0.009484223,-0.06529765,-0.005016911,-0.013904372,-0.07206256,0.008424173,-0.013011919,0.04289936,0.09708041,0.06572286,0.11341196,0.012868717,0.05244444,-0.07328726,0.030064272,-0.06637635,-0.007268687,0.04533263,-0.047801733,-0.051050246,-0.024118502,0.013079274,0.0021818841,-0.02532585,0.04379008,0.024515618,-0.03345186,0.058569707,0.016113149,0.021315617,-0.02366421,0.093248524,-0.058014393,0.009624303,-0.10340423,-0.0074627614,-0.026383802,-0.022602618,0.023186997,0.06988781,-0.061461423,0.063117966,0.054252226,0.024563055,0.069275245,-0.0027190764,-0.048666216,0.00808256,-0.016046504,0.020854803,0.04402317,0.0037265127,-0.027677774,0.03869099,0.02131717,-0.0036312893,-0.0036891527,0.022462133,-0.027981078,-0.026565997,0.0012667554,0.0059487806,-0.0033484686,-0.005999382,-0.0045233336,0.1306446,-0.042139467,0.08051363,0.037179735,-0.025684169,0.06408086,-0.02676573,-0.016565584,0.039429434,0.06892292,0.022170935,-0.01512702,-0.061771054,-0.024496466,-0.13309331,-0.016247112,-0.0066395393,-0.029162886,-0.04805254,-0.06321796,-0.05515315,-0.016074799,0.04872584,-0.040647592,0.08074213,0.006104045,-0.10686791,-0.12800945,0.1146466,0.046523385,-3.3997267e-08,0.022037681,-0.027235638,0.028954053,-0.05143965,-0.042873405,-0.004495613,-0.010220696,0.028129797,0.05674818,-0.045316663,0.016230153,0.0026578254,-0.03291879,0.076514766,0.035413615,-0.007690693,0.047489684,0.073959045,-0.035333578,0.0021294688,-0.039116595,0.011719343,-0.053899635,0.0006457722,0.010199639,-0.06524861,-0.015465993,0.022531793,-0.03735904,-0.0119681135,0.0036098612,0.022070155,-0.0055235703,-0.03200238,-0.063253425,-0.0048196716,-0.060237125,-0.013467016,-0.028246768,-0.024848558,-0.037312288,-0.105223045,-0.13416357,-0.03219179,0.013398124,-0.030825552,0.057846133,0.02995434,-0.0033743985,-0.026719088,-0.00022839491,-0.04898228,0.07869147,-0.065611765,-0.08251298,0.024166495,-0.030012188,-0.04872526,-0.016876277,-0.04255064,-0.0065036877,-0.019387128,0.19474344,-0.06296308 +3.5.99.16,"The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 3.5.99.15, deacetylisoipecoside synthase. The product is rapidly converted to demethylalangiside.",384,1.0,-0.035832554,-0.056471743,-0.04182315,-0.046728257,0.03260594,0.06720275,-0.033632368,-0.00016938812,-0.012207483,0.0138811795,0.05032506,-0.09221673,-0.0005922268,-0.09001021,0.018512506,0.05239839,-0.014114494,0.066970974,-0.09179635,-0.0850031,0.028053163,0.029588819,0.017601024,0.054325487,0.03807081,-0.0033382094,0.03630277,0.042967107,-0.030785263,-0.10823177,-0.02726186,-0.006077258,0.04182601,-0.07293967,0.06953659,0.0503114,-0.11489513,-0.10388914,0.11153041,-0.054627817,0.09054394,-0.00467198,-0.03809621,-0.033086944,-0.034868915,-0.072938114,-0.0421268,0.06335077,0.08570306,-0.0055778255,-0.030596992,-0.035654712,-0.013366163,-0.0750859,-0.035679925,-0.010100989,0.004715133,-0.0002735871,-0.018482145,0.042842656,0.07614203,0.04593051,-0.015890706,-0.023206888,-0.05752445,0.035677094,0.026138885,-0.08259342,0.062176168,0.0058782296,-0.0017939755,-0.0491074,-0.064003326,0.07081789,0.024998952,0.016634911,0.018107213,-0.0003396276,-0.023170494,-0.025774894,0.015184279,0.009674071,0.028555274,0.009715361,-0.01342379,-0.020504527,0.060426768,-0.004746658,0.0282414,0.050084427,0.06645188,-0.0380484,0.028044457,-0.055052947,-0.019387126,0.02366031,-0.0036670968,0.05034422,0.0010614749,-0.012651071,-0.026182361,0.013862477,-0.019032734,-0.049450155,-0.06242825,-0.04714197,0.0050406866,-0.017473139,0.031218015,-0.048235916,-0.024265591,-0.09873961,0.073553935,0.074000955,-0.061042413,0.060527813,0.08455954,-0.05045884,0.0069152685,0.002548445,0.079251714,-0.013845008,0.10234931,0.039746072,-0.035559505,0.04606743,-0.08790054,3.662744e-33,0.07060961,-0.017280092,0.066392906,0.065040536,0.018184807,0.0036904376,-0.08099993,0.01903982,-0.06524875,-0.048355732,-0.10970793,-0.00046285763,-0.0183562,0.048102252,0.0048713544,0.03714279,-0.021676622,0.06466789,0.053006005,0.0328514,0.017996393,0.04932771,-0.06802241,-0.016309021,-0.05576903,0.026292937,0.058380745,-0.025083829,0.09874351,-0.0035204426,-0.010713364,-0.05288204,-0.07387943,0.023816004,-0.020239575,-0.007701028,0.026454283,-0.038136475,0.05015626,0.04285919,-0.0061623063,0.096270025,0.021705138,-0.054173976,0.026470082,-0.005236949,0.0042503243,0.00360207,0.10992878,0.018050307,0.03553842,0.036225073,0.18996122,-0.021763142,0.030151565,0.0073051844,0.016510982,0.11015752,0.07764804,0.054822657,0.06338614,0.06558801,0.06624358,-0.024973774,0.058742136,0.029888874,-0.06787165,-0.03643456,-0.0211628,0.0036530362,-0.06082366,-0.01882964,0.006118939,0.052410286,0.073188394,-0.060466275,-0.093024366,-0.0032365706,-0.01603967,-0.028818004,-0.05696993,0.034280177,-0.058327004,-0.008391026,-0.010593321,0.0024395853,-0.053872343,0.062818326,0.039651953,0.0352111,0.041577112,0.006788175,-0.12979862,0.045799382,0.04571566,-3.7732123e-33,0.016526608,-0.07343285,0.010818619,0.0014716819,-0.06371108,0.0070702205,0.010125189,0.059679832,0.098926984,0.051946323,0.123261996,0.029924285,0.061002202,-0.061031718,0.019259425,-0.06858535,0.0143392645,0.04613494,-0.055303346,-0.044678744,-0.03939716,0.0045238053,-0.0084566595,-0.052089494,0.03899475,0.030315923,-0.034794778,0.08808312,0.0057435394,0.018878885,-0.013053271,0.08510502,-0.063699275,0.002387781,-0.12178986,-0.008868063,-0.011447573,-0.029126046,0.023171894,0.075581454,-0.06150139,0.047588103,0.044084754,0.025811799,0.06345382,0.0050674547,-0.059056,0.0037607495,-0.012443995,0.009876227,0.05378138,-0.0023669081,-0.023768574,0.029424906,0.020916464,-0.01575922,0.0038222647,0.013395941,-0.035028458,-0.010511361,0.004990498,0.020379795,-0.006952942,0.000820402,-0.034517124,0.12189433,-0.03874256,0.062550925,0.053191807,-0.03808236,0.074415594,-0.02967847,-0.002606715,0.03531142,0.06104441,0.028910499,-0.031637218,-0.05403691,-0.0260954,-0.123402864,-0.023265703,-0.019939635,-0.041888315,-0.035020072,-0.07092339,-0.03335547,-0.007349235,0.05147517,-0.022685211,0.05720999,-0.012679505,-0.10263093,-0.13759269,0.11531337,0.04700836,-3.488017e-08,0.015228834,-0.04099616,0.025153007,-0.043402523,-0.070580654,0.012225123,0.0014137254,0.027191192,0.05993646,-0.041618407,0.035400182,0.0031846242,-0.033128064,0.071140274,0.012641273,-0.010865613,0.057579983,0.0788766,-0.025405915,0.005157879,-0.042040125,0.00864844,-0.04903156,0.001153163,0.01490842,-0.06304908,-0.017748855,-0.0048858565,-0.0367082,-0.04825132,0.00015678126,0.023317698,-0.013356875,-0.012853156,-0.08040737,-0.004280612,-0.07268695,0.0002846791,-0.0032682512,-0.015243217,-0.014524631,-0.085138954,-0.14840946,-0.037668906,0.011477682,-0.008864971,0.03634713,0.029518409,0.0024575612,-0.040250946,0.0048066583,-0.025707893,0.07294161,-0.062323388,-0.07946717,0.034875188,-0.037134252,-0.06857649,-0.009950969,-0.04464455,-0.014860128,-0.01830474,0.17998542,-0.05012988 +3.6.1.77,"The enzyme belongs to the Nudix hydrolase family. It has been reported from bacteria, yeast, and mammals. Activity is higher with oxidized disulfide CoA than with reduced CoA.",384,1.0,-0.07235503,-0.07801252,-0.026316162,-0.053070225,0.060661126,-0.07770847,-0.08044521,0.03299821,0.026017612,-0.034347765,-0.00019040576,-0.038371418,-0.054843944,0.10078956,-0.1002658,0.035015054,-0.02437715,-0.058082998,0.03561913,-0.048368357,0.06625543,0.047169186,0.06374116,0.03677745,0.040815294,0.02940207,0.10548151,0.0013518,0.0055063386,-0.09241646,0.013514353,-0.03342063,0.0893244,-0.0131982,0.010564838,0.088980876,0.0017355705,-0.050207704,-0.0108271735,0.0129871555,0.07078394,-0.04478758,0.039496493,-0.0205728,-0.09000004,-0.0067265807,-0.045791384,-0.03167211,0.03480025,0.13958567,-0.048780084,-0.055284478,-0.03425114,0.076012805,0.05024207,0.019205812,-0.028174236,0.013603112,-0.06378798,0.04273886,0.025571048,-0.00080873154,-0.004096391,0.036401864,-0.0003845838,-0.019260481,0.045539126,-0.035828535,-0.036011696,-0.10954366,-0.008024551,-0.04093412,-0.0039082295,-0.0042159166,-0.019817911,-0.016869582,0.03787005,-0.04393666,0.034684606,-0.027690344,-0.013134491,0.06674305,0.05181216,0.109943815,0.011069478,0.004917317,-0.024819894,-0.008757351,0.02015333,-0.042894088,-0.037715793,0.045774464,-0.038985375,-0.002950115,-0.01691684,0.06911818,-0.013301047,0.03858223,-0.039114203,-0.05739874,0.014476683,0.06318145,-0.09170581,-0.10006282,-0.07605828,0.027189642,0.007654063,0.0835035,0.008120388,0.04028433,0.014864779,0.06248804,0.022682847,0.04284582,0.01310392,0.0046856683,0.023011249,-0.026053447,-0.04132132,-0.03884044,-0.0014180165,-0.0358514,0.075195596,0.04838708,-0.020092536,0.03397164,-0.0960917,1.5397732e-34,0.02415486,0.027730497,-0.022322092,0.054456007,-0.026652038,-0.026376162,-0.06297033,0.062973395,-0.12058373,-0.06621887,-0.027145863,-0.009882888,-0.019745316,0.025561295,0.022691041,-0.052954104,0.07096573,0.03388017,0.005562015,0.041468937,0.017659975,0.123158,-0.024299951,0.033385284,0.044411547,0.03508812,-0.03543371,0.029781107,0.06051548,-0.007378036,-0.01715391,-0.07337266,-0.056930933,-0.033106215,0.03944569,0.02540424,-0.0711408,0.0030115042,-0.025066435,0.0790379,-0.009231206,0.028567543,0.01469363,-0.1108791,0.037794992,-0.07092562,0.019798215,0.045350168,0.017754653,0.0037126981,0.020829227,0.006616159,0.10282547,-0.029020432,-0.023125477,0.027409792,0.010457497,0.034634177,0.03070849,0.010945732,0.01998459,0.038255487,-0.057774283,0.079929,-0.030412972,-0.0049129445,-0.031623136,-0.035502896,-0.019808562,0.150509,-0.07712758,0.05591807,0.008500538,-0.023723729,0.0094211055,-0.08863423,-0.013241251,0.04610335,0.07789123,0.0042236866,0.062038016,0.010780311,0.07813815,-0.019871417,-0.036837414,-0.0037886568,0.02341289,0.050174437,-0.032097656,0.04635338,0.07169565,-0.11455966,-0.07262733,-0.03519867,0.013025209,-9.130536e-34,0.106425755,-0.089568466,0.016759394,-0.107616596,-0.09035631,0.056264345,0.057685602,-0.031334687,0.027141891,-0.041821532,0.11550792,0.016116293,-0.021193448,-0.05758451,0.032069325,0.046952926,0.013844256,0.0503638,-0.028812619,-0.098492526,0.0020047214,0.12873873,0.00078180275,-0.039480623,0.05298879,-0.0116184,-0.026329312,0.11805179,0.04215182,-0.0065673557,-0.0984872,0.022164049,-0.018764198,-0.042057537,0.00097245263,0.060945783,-0.10351892,-0.0050937166,-0.040888038,-0.011822665,-0.03752398,0.028569032,0.0152134085,0.039418317,-0.007632105,0.021221573,-0.086858824,-0.0067110443,0.007703414,-0.011030628,0.026970085,-0.036450166,-0.022290662,0.051328976,0.04497134,0.044888217,-0.032125928,0.024196163,-0.0007254971,-0.097088166,-0.03859598,0.0008736463,0.0064283432,0.007911014,0.011500892,0.09375956,-0.14302608,0.058716223,0.022298738,0.014268305,0.04828986,-0.00060025905,0.026441688,0.0072887368,-0.02257765,-0.02151676,-0.094176956,0.037838966,0.007910731,0.049726468,-0.012730938,-0.008950026,-0.042712197,-0.016497586,-0.009182053,-0.05042157,0.0785812,0.057283424,-0.026825644,0.0049935267,-0.024818493,-0.02201667,-0.07518862,0.04533772,0.03860401,-2.946114e-08,-0.024092063,-0.07245012,0.022498477,-0.0693788,0.044018034,0.016636953,-0.0008764226,0.023155304,0.031821106,0.04694956,-0.01899516,0.05935503,0.020194592,-0.0150497295,0.032252908,-0.015056357,0.0012617984,-0.028619248,-0.021638326,-0.023194885,-0.008847116,0.0037553657,-0.06431623,0.08526696,-0.06573157,-0.0024880886,0.03760477,-0.029124131,-0.01690829,-0.028547956,-0.019813294,0.022514576,0.0066600647,-0.07019117,-0.043124963,0.05178629,0.016825743,0.033416115,0.0005369707,0.06372946,0.06799322,-0.056622032,-0.030359719,0.037936546,0.0052906713,0.03606948,-0.03564254,0.009261493,0.009808806,-0.022671886,-0.02573594,0.03335095,-0.09880242,-0.017686516,-0.10236145,-0.048892118,-0.0102995215,-0.10040695,-0.015720068,-0.0908381,0.049412373,0.023876304,0.24268927,-0.01726741 +4.1.1.127,"A pyridoxal 5'-phosphate protein. The enzyme, characterized from the cyanobacterium Synechocystis sp. PCC 6803, participates in a biosynthetic pathway for spermidine.",384,1.0,-0.090227135,-0.03873038,-0.09994242,-0.08567158,0.019592803,0.057213884,-0.030104702,0.025402699,0.052788604,0.06395195,0.008566358,0.025679506,-0.1202157,0.0811013,-0.029842507,0.05705359,-0.05745957,0.005602305,0.034190875,0.0057642367,0.10773868,0.046658833,-0.012193388,0.0009968714,0.02116935,0.048676543,0.004284073,0.09340324,-0.038730137,0.039681736,-0.045744788,0.033307366,-0.022246238,-0.07854872,0.08674419,0.089636154,-0.11372786,-0.027100645,0.06796796,0.0027065282,0.12572204,-0.048406232,-0.05325501,0.058299314,-0.042541064,0.07603321,0.089188,0.029349314,0.0860476,-0.05435975,-0.05669381,-0.016806878,-0.006887791,-0.026341144,0.02683127,0.0026724783,0.005531494,-0.04736053,0.0015850012,-0.0045324527,-0.009883335,0.02478862,0.0053735203,0.024529384,0.08084126,-0.039599195,-0.039214578,-0.026165208,0.0054306122,-0.009754358,-0.04213439,-0.025945494,0.09118468,0.029312108,-0.04792371,0.05910535,-0.019412052,-0.01475,-0.035033397,-0.051319122,0.02185566,-0.05545614,-0.034149196,0.049743067,0.03679251,-0.029262394,0.04599947,-0.0053764316,-0.014533124,0.00036514932,0.026633866,0.019663779,0.04335357,-0.076625384,-0.047298092,0.017889151,0.025632478,-0.041843567,-0.039202526,-0.022990236,-0.006434727,0.06438321,0.015448698,-0.104752444,-0.05819811,0.015404231,-0.053030435,0.07832481,0.02408284,0.0034960068,-0.09075514,0.034621373,-0.055870287,0.0075360257,0.021572469,0.003709895,-0.011937239,0.015321925,-0.025410011,0.050910357,-0.014214637,-0.080089636,-0.023015926,0.062377997,-0.036144547,-0.013647484,-0.08271728,1.3560933e-33,0.10407765,0.021490641,0.039414175,0.025912106,0.00060694054,0.03580212,-0.010328985,-0.11634722,-0.024358153,-0.05092139,-0.041638378,-0.07263637,0.029191706,0.019774942,-0.10501295,-0.010933203,-0.11010057,0.029798845,0.06975745,0.033808477,0.07191716,0.089666046,-0.033763275,0.047272652,-0.013110893,0.063143514,-0.07319786,-0.008923765,0.036574405,-0.013860756,0.008398965,-0.018397728,-0.12248377,-0.032541122,0.109425925,-0.07598725,-0.027239,-0.1142781,-0.0017706056,0.026871542,-0.06963579,-0.080542654,-0.0050013205,0.023004944,-0.020795692,-0.058301177,-0.023651207,0.06887847,0.04253729,-0.003182325,0.020956367,-0.044264086,0.1093332,-0.027833503,-0.106983595,-0.044339284,-0.048307322,-0.015454722,0.0027709762,0.008326824,0.07541426,-0.011951029,-0.042716626,0.03680059,0.015002522,0.0021224685,-0.035354704,-0.033016864,0.08339308,0.08200846,-0.018883474,0.0001868467,0.05258339,0.041583903,0.027767012,-0.010912184,-0.08604634,0.0020557586,-0.030138662,0.03299578,-0.013052326,-0.08924888,-0.0676316,-0.027791023,-0.04338374,0.023712512,0.008058697,-0.06503035,0.012168999,-0.04530667,0.04336213,-0.12312827,-0.032756954,0.009435564,-0.020489974,-2.6413384e-33,0.08755221,-0.102010876,0.07683375,0.036845777,-0.008329659,0.026036626,0.069315754,-0.024053305,-0.039642874,0.012233535,0.071046375,-0.023978908,0.0996882,-0.037357353,-0.028554447,0.043377995,-0.010050632,0.047732227,0.057864107,0.03559111,0.018320404,0.0071000378,0.038622957,0.030702319,0.06788764,0.0043674316,-0.048065692,0.012886099,0.007906236,-0.006612708,-0.044125684,0.11490434,-0.03797793,-0.004620232,-0.010817979,-0.0011739378,-0.072422445,-0.017707648,0.049247105,0.022748208,0.033898667,0.031571813,-0.018476706,0.04565335,0.004998963,0.018144766,-0.01406223,0.08341934,0.034524053,0.0030271094,0.014375854,0.05273784,-0.024438323,-0.015860625,0.05784634,0.00993161,-0.0024495826,-0.010770315,0.0524266,0.04791723,-0.036314946,-0.0769871,0.015812581,0.08534097,0.050247073,0.083759494,0.025479786,0.08858296,0.04525043,0.007824571,0.0877486,0.00085165666,0.10827836,0.04143716,-0.020765234,-0.043739926,-0.026053013,0.0100488905,0.0020742635,0.013853881,0.015618842,-0.039934486,-0.025316471,-0.032262553,0.0028710167,-0.0043404903,0.11450764,0.09214721,-0.053177565,-0.018435678,-0.0027954704,0.006369352,0.0054880846,0.08844301,0.059361264,-3.2401257e-08,0.07302498,-0.039254453,0.05135706,-0.08435828,0.050159954,0.012044884,0.01732747,-0.01700693,0.029306551,-0.031897344,0.033156708,-0.053536918,0.03223777,-0.0048487945,0.083253175,0.050681546,-0.011172803,0.0035625931,0.008227663,0.00045345648,-0.029693734,-0.052586623,-0.1485094,0.04476307,0.037365768,0.029612428,-0.018437997,0.026426729,-0.027793936,-0.04266971,0.04109008,-0.045307964,-0.05606846,-0.032240037,-0.056062683,0.13008119,-0.09478844,-0.042340454,-0.02470458,0.0031070174,-0.08156354,-0.033979166,-0.03748754,-0.015931576,-0.013984569,0.042379703,-0.041589852,0.024676342,-0.086654894,0.00023413423,-0.00279746,0.013390455,-0.053830717,-0.07181379,-0.06757131,0.029428555,0.028029952,-0.015589315,-0.058564976,-0.055294305,-0.015113645,0.010486345,0.106548674,-0.090792105 +4.1.2.65,The enzyme is located in the chloroplasts of vanilla pods of the orchid Vanilla planifolia. It also converts ferulic acid 4-O-beta-D-glucopyranoside to vanillin 4-O-beta-D-glucopyranoside.,384,0.99999994,0.0121059995,-0.055002,-0.087900385,-0.017073024,0.14108774,0.02391853,-0.041227292,-0.0005449659,0.05340438,-0.09428837,0.019533264,0.044084284,-0.15893497,-0.028948506,-0.06086078,0.030175168,-0.0065337755,0.04863017,0.01691059,-0.015394109,0.053882543,0.010978414,0.02950412,0.04020579,0.0025897524,0.0049478686,0.011437891,-0.036587227,-0.01277225,-0.107383184,-0.041485593,-0.03952966,0.08332162,0.014506456,0.0030818433,0.035875402,-0.044209998,-0.069722034,0.08311762,-0.04582416,0.028386593,-0.012581498,-0.081229046,0.021266751,-0.109195106,-0.0013461823,0.0039267694,-0.031244928,0.06422114,0.038033243,0.031194631,-0.098531626,-0.039671432,0.018214438,-0.027016098,0.020300826,0.010906405,0.025813857,0.0065863887,0.11455315,0.06835289,0.045955595,-0.01901965,0.04584938,-0.02812218,-0.016181817,-0.0062706727,0.0045227334,-0.0057501146,-0.10529511,0.024675315,-0.029741844,0.029762024,-0.04305956,0.026642365,0.04932488,-0.011889931,-0.002101752,0.044637498,0.03188289,0.08105564,0.06152623,0.014492171,0.10532706,0.0021797877,0.035249133,0.00075310166,-0.012312544,0.046688214,-0.024486205,0.058541577,-0.021697057,-0.111828536,-0.024868026,-0.022782959,0.06132449,0.037014402,-0.028700257,0.016347481,-0.023189697,0.0036258304,0.039936054,0.0008648365,-0.1307306,-0.076992236,0.057435006,-0.025528817,0.015252159,0.03982547,-0.006047821,-0.02057945,0.01713479,0.09326441,0.030463,-0.039176244,-0.028406387,0.020584384,-0.0052280123,-0.069270715,0.029139964,0.0044352785,-0.0056893514,0.07113512,0.09927075,-0.04412977,0.03939056,-0.08119861,2.0214905e-33,0.03776118,0.030484337,0.0045799348,-0.0115192775,0.026551466,-0.025315488,-0.06398645,0.0018312358,-0.12456673,0.008182134,-0.05597292,-0.108095735,-0.023480786,0.022043407,-0.016804555,-0.0110497605,0.026218232,0.023710994,0.06379103,0.023120334,0.010619302,0.082281455,-0.09393463,0.0863651,-0.04459746,0.12133931,-0.05517749,0.02728468,0.073893845,-0.015816998,-0.032117486,-0.05661152,-0.018309046,0.03987678,0.013405977,0.030684168,-0.02859517,-0.062187005,-0.028441114,0.035606343,0.04298481,0.05339351,0.027867382,-0.0014434084,0.030831324,-0.0047323615,-0.010579486,0.10184211,0.068731524,0.06751747,-0.03484542,-0.04407136,0.050309144,-0.010379825,-0.04169745,0.016215887,-0.07057182,0.009514674,0.086708374,0.029376967,0.025186526,0.048964787,-0.031504255,-0.040876266,0.07468389,-0.027505308,-0.07947526,-0.06946824,0.023871073,0.05550101,-0.05349718,-0.014676782,-0.0034649454,0.0770102,0.048122793,-0.03298344,-0.013430876,-0.027149206,0.07435866,-0.06456689,-0.032483727,0.013988464,-0.0007356353,-0.02352249,0.0007511222,-0.039516706,-0.038110808,0.0014534405,-0.022046745,0.057597693,-0.0021523407,-0.06497195,-0.088144,0.017917354,-0.026505591,-2.962694e-33,0.09763156,-0.13161281,0.05473105,-0.060148362,-0.057061426,0.06232889,-0.055001512,-0.030774489,0.0025128347,0.06831874,0.03496525,-0.020776704,0.014400933,-0.026381839,0.013804389,0.033403765,0.00033997823,0.030064201,-0.060463257,0.024015022,-0.061311215,0.07198069,0.06660168,0.001799247,0.026519777,0.024662483,0.06878158,0.057179753,0.060705133,0.011929165,-0.055423442,0.0051325914,-0.04367234,0.0095024975,-0.05000743,0.05332664,-0.04588705,0.0014355929,0.06969133,0.03782486,-0.039115947,0.031313695,-0.049001087,-0.030960666,0.028082041,0.04147353,-0.07502209,0.08332215,0.019628344,-0.07450442,0.00049638696,1.9824978e-05,-0.06995216,0.06182309,0.041598152,0.002119735,0.018227117,-0.028209459,-0.008933324,-0.048652522,-0.042832766,-0.04811199,-0.006565403,0.015621995,-0.00958914,0.07473055,-0.045508392,0.07326663,-0.028321778,0.027665975,0.032308623,0.002637364,0.04135872,0.08220753,-0.0003045371,-0.06339275,-0.008529616,-0.06808161,-0.003081213,-0.039616216,-0.050742574,0.061549682,-0.026460249,-0.061417248,0.02001763,-0.07515904,0.055502195,0.11735736,0.037212916,0.021349214,-0.032939237,0.052796625,-0.049472995,0.026865035,0.095359236,-3.5148897e-08,0.012591261,-0.001812072,0.09262351,-0.0882134,0.005244165,0.01108451,0.011943116,0.024563225,-0.019847438,0.0038720572,-0.036579482,0.08274797,-0.017578952,-0.038706873,0.014057686,0.036947977,0.013881186,0.09513012,-0.0031714512,-0.009992024,-0.069835424,-0.0013216258,-0.09211108,-0.03297916,-0.019449862,-0.10775912,0.04744132,0.0388421,-0.03251589,-0.00753506,0.03141035,0.045920562,0.019247808,-0.12567669,-0.033766557,0.030575205,-0.04854173,-0.014097757,-0.017644305,0.002396058,-0.0048528104,-0.058442168,-0.0113918455,-0.018177273,-0.054395616,-0.03717042,0.06750838,0.04583454,0.03195468,0.08920455,0.042308737,-0.068177655,-0.015011983,-0.06386126,-0.08095311,-0.071420625,0.01223076,-0.08422752,-0.032137346,-0.083910316,-0.075162455,0.033872463,0.18231547,-0.054279864 +4.1.2.66,"The enzyme has been purified from vanilla pods of the orchid Vanilla planifolia. It is highly specific for 4-coumarate. Similar compounds such as cinnamate, caffeate, sinapate and o-coumarate are not substrates.",384,1.0,0.03600154,-0.07124581,-0.071020395,-0.03913113,0.10248478,0.0882365,-0.059964187,0.012783524,-0.00386004,-0.040585026,0.038977582,-0.05289227,-0.15095662,-0.044438,-0.050153065,0.02010659,-0.0033294281,-0.01261718,0.062553726,-0.04275194,0.04151296,0.0012485434,-0.017728513,0.05153571,-0.02623806,0.08036793,0.0052751037,-0.062362008,0.05501907,-0.07829372,-0.052077472,0.019656315,0.009624137,-0.022499062,-0.04876649,0.048908655,-0.09042838,-0.1132371,0.05858585,0.0054189404,0.042926352,0.012656679,-0.06559386,0.016851733,-0.0320324,-0.06808442,-0.032631826,0.006933347,0.030022616,0.017850386,-0.016696224,-0.056206163,-0.04374925,-0.017422043,-0.025373122,-0.045563795,-0.031524062,0.03372334,0.0029385183,0.13442057,0.058477614,0.010105545,-0.0006640205,0.02868036,0.009644135,0.0021800664,-0.010914921,0.00976722,0.05269714,-0.06521538,-0.0060100136,-0.079155706,0.030540142,-0.041264057,-0.03941601,0.12687154,-0.040868573,0.0061144466,0.0028293608,0.014862145,0.019879632,0.051235214,0.07594878,0.063206345,0.016818458,0.039669257,-0.025332775,0.012124163,0.050848342,-0.009635112,0.039929315,0.058820207,-0.05169007,-0.004327666,-0.041985765,0.10631011,0.039604258,0.027913745,-0.006835506,-0.046644527,-0.01763121,0.04085598,-0.051749285,-0.091776185,-0.10571831,0.037421126,0.0034436886,-0.008335834,0.06441304,0.07512758,-0.046224594,0.008369565,0.0064550503,-0.025554292,0.016552875,0.06666092,-0.021527521,-0.04649156,0.008300563,0.022480749,0.020980047,-0.049907118,0.12789176,0.021759706,0.0032412296,-0.0021577403,-0.00425747,9.288521e-34,0.05136079,0.052885685,-0.013535772,-0.009829587,0.02346715,-0.050265543,-0.05212649,0.053325646,-0.115895055,-0.0077033816,-0.00016665224,0.011474981,-0.04129341,0.0002136384,0.019516194,-0.0181493,0.013572687,-0.01836449,0.10227161,-0.000874123,0.034456525,0.08570819,-0.0931515,0.106734835,-0.06842096,0.06793841,-0.08150104,0.008943424,-0.0049997307,-0.020074245,-0.009817021,-0.07097702,-0.021313414,0.032912545,0.014067415,0.024218993,-0.04916692,-0.023522023,-0.093888074,0.08180235,0.07904014,-0.009808679,0.06831337,-0.019332638,0.021679765,-0.057816267,-0.08279697,0.020479236,0.01584388,0.064912215,-0.04701762,0.035899267,0.05828341,0.026538623,-0.0561205,0.010646732,-0.04595331,0.00526857,0.09171179,-0.0090568,-0.045634307,0.016303685,-0.031199282,-0.0035566778,-0.00048028212,0.011635862,-0.09851388,-0.040970594,0.08938075,0.08883231,-0.03642178,-0.025914336,-0.023998424,0.039069846,0.10729764,-0.03954072,0.002553897,0.043103997,0.016438447,0.0017527057,-0.00428305,-0.007873415,0.014379889,0.030053213,-0.017048981,-0.046099536,-0.055357527,0.060304306,0.010782424,0.029508758,0.017883908,0.0018787651,-0.025603896,0.007949735,-0.05794205,-2.117617e-33,0.07105167,-0.06954477,0.042358335,-0.04131821,-0.08945851,0.10806923,0.009485099,-0.040188447,0.020689974,-0.020172432,0.08191148,0.014161147,0.017374363,-0.04997107,-0.056017846,0.0630908,0.011222862,0.06944764,-0.046936303,0.018783676,-0.051266853,0.05825127,0.025540512,-0.012980977,0.032505408,0.08019833,0.13980067,-0.028209116,0.04482921,0.053957578,0.020845585,-0.015288758,-0.012581225,-0.012001563,-0.055890787,-0.025013935,-0.047838356,0.013747894,-0.014829956,0.037436843,0.020294733,0.035875726,-0.028001918,-0.0024408172,0.03838974,0.010136978,-0.09566623,0.039133072,0.014994002,0.0015159595,0.058353372,0.019694759,-0.10786669,0.015393688,0.011786533,-0.030194115,0.0352053,-0.055291843,-0.0032403073,0.015739387,-0.00794299,0.010789121,-0.039573643,0.0032601024,0.09276228,0.051524613,-0.053345192,0.07874413,-0.042656917,0.0111781815,0.026851848,-0.0067384145,0.019390505,0.075281516,-0.0011351068,-0.042535428,0.005062996,-0.05035903,-0.012369118,-0.009309888,-0.0063941986,0.045127455,0.0050194818,-0.069057345,-0.012206014,-0.029312728,-0.011817911,0.024052601,0.065447785,0.06794013,-0.0503829,-0.014470179,-0.06810698,0.01700551,0.089888774,-3.2765396e-08,0.02572917,-0.004319236,0.062454637,-0.030732533,0.0076279854,0.0408685,-0.0033728892,-0.039019343,0.03138686,0.02760144,-0.05064673,0.022771593,-0.032370906,0.047387604,0.03838561,-0.035661984,0.022885783,0.07670835,-0.04005162,-0.03792199,-0.09934791,-0.019384863,-0.041990113,-0.035162784,-0.010880284,-0.06437371,0.04107257,0.035828643,0.0013161493,0.0290702,-0.037358593,0.05518403,0.035153307,-0.06052022,-0.055818178,-0.016738161,0.066955924,-0.058336984,-0.10424097,0.004101562,-0.07660313,-0.08705514,-0.03155405,-0.038677834,-0.0019453756,-0.042148948,0.08157744,0.0033186167,0.051326927,0.0622535,0.022581981,-0.026797296,-0.0031432377,-0.076340966,-0.045976046,-0.1212518,0.025775086,-0.061892048,-0.062141232,-0.17641057,-0.01845125,-0.026624652,0.23535052,-0.04625022 +4.1.99.29,"The enzyme participates in alternative menaquinone biosynthesis pathways known as the futalosine and modified futalosine pathways, which occurs in some bacterial species including several human pathogens such as Helicobacter pylori, Campylobacter jejuni, and Chlamydia.",384,1.0,-0.024061263,-0.0059555825,-0.17444436,0.0055787503,-0.01956124,0.05601878,-0.076112404,-0.005781155,0.087104894,0.033486307,0.013060509,-0.023370493,-0.07669164,0.042857114,-0.0062690433,0.043678753,-0.13590056,0.022132916,0.01942673,-0.04332517,0.0653984,0.0062591205,0.004937966,-0.09002686,-0.045382738,-0.01967965,0.01782557,0.050669074,-0.00559139,-0.01256095,-0.0021030745,-0.00085368054,0.068150945,-0.05045028,0.038899634,0.091344476,-0.04080161,-0.06550887,0.10410871,0.02978898,-0.008027797,-0.036725074,-0.0050073853,-0.012849235,0.0038869055,-0.005951226,0.0010301002,0.020609017,0.073213115,0.026486477,-0.049020737,0.005789784,-0.020994838,0.028994473,0.08099043,0.0012138824,0.006544162,-0.027151823,0.008614801,-0.019919995,0.019195316,0.006372192,0.027142314,0.03434095,0.0020844392,-0.072746456,-0.07414102,-0.022792244,0.025424628,-0.018907381,-0.013430322,-0.017817099,-0.021757204,0.0025433088,0.028703686,0.042334672,-0.03989977,0.024131345,0.024372146,-0.005882466,0.029999563,0.04362053,0.044912226,0.11912927,0.0697656,0.0037970638,-0.023701103,-0.014027684,0.013408249,0.10912456,0.032876592,-0.051479664,-0.0013187133,-0.03779587,0.008912023,-0.03538314,0.017871412,0.025986264,-0.018589182,-0.03979774,-0.014506545,-0.05409196,-0.049863737,-0.064793766,0.007161837,0.03961221,0.048344392,0.08310146,0.03218325,-0.0169291,-0.06324046,0.041788798,0.030943338,-0.05144868,0.030574916,0.03945754,0.0738486,-0.015429609,-0.036259253,0.031302802,-0.011192183,-0.011972292,0.06666959,0.09211485,-0.02707849,0.007792474,-0.09898632,4.7865928e-33,0.046321634,0.023208901,0.017109806,-0.0008545294,0.035049822,-0.015665745,-0.010723318,-0.10753796,-0.01793457,-0.05100898,-0.07074015,-0.024641223,-0.01060066,0.009391567,-0.013949851,-0.022979025,-0.024751905,-0.023080595,0.040634423,-0.013191983,0.0060293535,-0.022790825,0.011961945,-0.09748409,0.044943016,0.058386784,-0.018292703,0.05684032,-0.010050834,-0.010712841,-0.036836624,-0.054993495,-0.09668596,-0.049365927,0.03197698,0.035986044,-0.06730557,-0.05199434,-0.083282426,0.037592787,-0.012154778,0.016331118,-0.11251442,-0.007348594,0.051539518,-0.004407696,-0.024162801,0.095986344,0.11159721,0.006273131,0.023023527,0.012018556,0.11763519,-0.06354646,-0.060764074,-0.04654332,0.04362949,-0.014793193,-0.009505386,0.08387423,0.005461571,0.006524999,-0.009552924,0.075430885,0.013708749,-0.028847056,0.030772798,-0.058845405,0.0118284635,0.07836989,-0.090717554,-0.0119571695,0.026015038,0.001645228,0.032387417,-0.029510463,-0.10712305,-0.054549694,0.026416285,-0.09782088,0.015816784,-0.117517516,-0.007593072,-0.021550028,-0.021528417,0.01119186,-0.068886206,-0.07251747,-0.00052475475,-0.0131347785,0.0739503,-0.09035271,-0.01879589,0.06673987,0.06886684,-6.889406e-33,-0.034960907,-0.056231525,0.009936605,-0.124913506,-0.0785682,0.063864656,0.0067357924,-0.043686956,0.027065048,0.026513364,0.01849071,-0.07020111,0.09437177,-0.043464705,-0.031430595,-0.0013687427,0.023939732,0.074247584,0.015900457,-0.0456322,0.0050438815,0.042482216,0.04363347,-0.051026113,-0.018982055,0.053998962,0.005007801,0.061490115,0.012088816,0.041496806,0.023724852,0.047822863,-0.110873744,-0.07166352,0.051608603,-0.039525487,-0.055489484,0.034315556,0.119897,-0.037027776,0.08466431,0.06177262,0.06290697,0.06903834,0.012041288,0.12507981,-0.0783679,0.04698998,-0.048250686,-0.059824996,-0.034585886,0.011214432,-0.06697669,0.057766885,0.0050939936,0.049784377,0.02536885,-0.06616158,0.030247757,0.013046801,-0.11016863,-0.033050925,0.03252902,-0.0016550834,0.0072831153,0.033182297,0.012128591,0.054258935,0.05855056,0.0033060128,0.09302778,-0.011898406,0.0101418495,0.0577988,-0.057617288,0.008636489,-0.064333744,-0.040848177,0.05723249,0.052655503,-0.009484121,-0.009239634,0.012021247,-0.022039793,-0.058663607,-0.11042787,0.061112594,0.07993952,-0.010773458,0.07233548,0.025206875,0.00415485,-0.07050116,0.018514575,-0.020532303,-3.7384734e-08,-0.015016548,-0.084106386,0.019827316,-0.033608828,0.044131435,-0.0021932279,-0.10062158,0.07260602,0.0776807,-0.0021542283,-0.046903774,0.06452469,0.043501064,-0.014410183,0.006734624,0.08967241,-0.017622473,-0.016819596,0.02116926,-0.06652794,-0.05326966,-0.010762891,-0.061852317,0.07732065,0.022800023,-0.066675715,-0.010461848,0.05938314,-0.0066843405,-0.03603676,-7.5498065e-05,0.04929164,-0.019586645,0.0039074197,-0.146247,0.062377837,-0.025130374,-0.06435034,0.004969538,-0.04862741,0.011903996,-0.057476085,0.0012681034,-0.011170469,-0.005019719,0.014574705,-0.007554001,0.061667185,-0.040909745,-0.072571345,0.0036984948,-0.03705114,0.019017259,0.023215303,-0.08553121,-0.0010451282,-0.016894342,-0.014192931,0.034190267,-0.067996815,-0.064831585,0.011670496,0.1794072,-0.07079736 +4.2.1.183,"A heme-thiolate protein (P-450) occurring in several plants, including Allium sativum (garlic) and Selaginella moellendorffii (spikemoss). The enzyme also catalyses the reaction of EC 4.2.1.121, colneleate synthase, to a lesser extent.",384,1.0,-0.06700595,0.01856058,-0.049312513,0.017194903,0.09623765,0.07255446,-0.054340683,0.07899884,0.011619459,-0.015084447,0.015859457,-0.075954154,-0.083023995,-0.057883333,-0.058503468,-0.02884781,-0.06650614,0.038230244,-0.032312173,-0.1376221,0.027034873,0.05183144,0.008144644,0.013778172,0.030314375,0.028542232,0.0119837755,-0.017076971,-0.014012203,-0.10450783,-0.049968895,-0.01568449,0.07668299,0.0052959486,0.015198141,0.056693364,-0.106388435,-0.11866964,0.04388046,-0.031764485,0.11907821,-0.08403511,-0.05607512,-0.04162418,-0.07017881,-0.009789655,0.035957336,0.037319593,-0.01204026,-0.04036253,-0.030649476,-0.07673633,-0.031419788,-0.0030064424,-0.056728143,-0.0018335502,0.04310648,0.08426536,0.021815417,-0.015158015,0.03689937,0.02127834,-0.013000973,-0.0072492254,-0.01482448,-0.00023657306,-0.00937822,-0.02036588,-0.016979216,-0.034026664,0.0004230303,-0.03552074,-0.009443406,0.08440999,-0.0028494522,0.09608993,-0.0829871,-0.006957429,0.039955933,0.002128957,0.01972228,0.0617741,-0.015763693,0.04125442,0.03297802,0.049509525,-0.018317703,0.06201027,-0.018953763,-0.060495127,0.054693736,-0.008094708,-0.05412265,0.03412814,-0.086799055,0.14949276,0.045923498,-0.030738331,0.052116416,-0.030477706,0.016997015,0.031428598,-0.03911442,-0.081767306,-0.037925165,0.039964072,-0.009128267,0.01738865,0.022709282,-0.04474058,-0.022253698,-0.065916136,0.008677946,-0.028781781,-0.016895046,0.054229334,0.0074667796,-0.049716715,-0.027272169,-0.060754977,-0.031672508,-0.05376675,0.027188158,0.081511386,-0.04808328,0.010816025,-0.14335714,2.7569804e-33,0.092779405,0.037815057,-0.016857278,-0.029097557,0.017062115,-0.04162265,-0.057968833,0.06910029,-0.05989829,-0.0052004154,-0.100692704,-0.07830388,0.04474376,-0.05634547,-0.0028047017,-0.04317648,-0.008814326,0.033928458,0.038432766,-0.021207202,-0.04562893,1.7618667e-07,-0.07475631,0.06172134,-0.02099314,0.07529114,0.03860754,-0.051872317,0.08630225,-0.013472993,-0.05319125,-0.042174276,-0.011727683,-0.029172936,0.02316077,-0.023001825,-0.027693624,-0.021455053,-0.08354877,0.029063165,-0.0009251106,0.05156873,0.03334808,-0.08534493,0.048927117,-0.047170274,-0.098414,0.035964582,0.05355805,0.026201729,0.02985607,-0.03303837,0.17167172,0.033312444,-0.0119282445,0.01404564,0.005628221,0.076007195,0.049709372,0.06869837,0.07775748,0.05340409,-0.06055312,0.020009978,-0.034131903,0.09424696,-0.08203175,0.0023261984,0.01399656,0.061230402,-0.012547524,-0.020770766,-0.02017414,-0.021113664,0.02160366,-0.040866885,-0.020699363,0.0742014,0.006500568,0.010234516,0.035010867,0.010370013,4.561355e-05,0.00393802,-0.03642208,-0.014807126,1.211453e-05,0.02935827,0.0046863477,0.058881376,0.097145885,-0.04545765,0.0074606715,0.020386983,-0.05187465,-1.0038665e-33,0.08377742,-0.05862013,0.01870951,-0.039536692,-0.056987446,0.071652144,-0.020452334,-0.027404105,-0.002336487,0.014924941,0.11181986,-0.025313506,0.062236086,-0.08115188,-0.012011135,-0.013653423,0.0196292,0.00839379,0.0058575785,0.053786844,-0.03519841,0.029283393,0.037103347,0.023286493,0.047559544,0.03629429,0.040095415,0.06461638,0.01377271,0.013025177,0.02073456,-4.9871982e-05,-0.07218504,-0.013834811,-0.07694915,0.0037677293,0.04884971,0.030115834,0.021109933,0.016021822,-0.03974561,-0.00022575166,0.069624186,0.13262717,0.099146366,0.056670163,-0.0515532,7.675468e-05,-0.09187665,-0.0037444767,0.04316698,-0.00081998017,-0.01074628,0.02765576,-0.0011695448,-0.019944733,0.013208562,0.026938641,-0.033109307,-0.08497817,-0.018077917,-0.060770195,0.015894853,0.091691166,0.045514014,0.06341317,-0.13066734,0.058592968,-0.011138577,0.050202094,0.09959694,0.009516467,-0.035930417,0.05657225,0.019718068,0.0021584323,0.046603236,0.013018492,0.01838781,-0.008241226,-0.057351332,0.028485747,-0.03188837,-0.101646006,-0.012637755,-0.06453838,0.0023530445,0.14638223,0.038706534,0.06604032,-0.06463559,0.014403103,-0.012464711,0.07162003,0.1310585,-3.8250324e-08,-0.038220014,-0.06671595,-0.034464788,0.004776638,0.04304326,-0.025506187,0.07319247,0.024924563,0.074008316,-0.007041622,-0.054008123,0.023456315,8.777107e-05,-0.022302805,0.06115562,0.020281738,0.030444937,0.04620193,0.011489303,0.0479088,0.016664466,0.020113355,-0.06515596,-0.0069271913,0.040813774,-0.082044646,0.010180809,-0.046998076,0.010472724,-0.025389194,0.025412826,0.030075012,0.023316542,-0.040714268,0.037206985,0.07059343,-0.021291796,-0.02305532,0.00046640818,-0.023868002,-0.0243086,-0.04858418,-0.053648427,-0.04927771,-0.0048960284,0.006366027,0.0264447,0.04836617,0.026744766,-0.029033367,-0.021970764,-0.02257605,0.013826677,-0.113353,-0.10082725,-0.032701544,0.09675096,-0.0053253355,-0.008842865,-0.072518356,0.012238538,-0.015485329,0.15206672,0.020025633 +4.2.3.220,Isolated from the fungus Talaromyces verruculosus.,384,1.0,-0.031208176,0.015119812,-0.10771886,-0.015714029,0.027763482,-0.004408377,-0.034020554,0.045582525,0.0113979895,-0.012025845,0.09306217,-0.028044347,0.0409985,-0.004173004,-0.094033234,-0.0031701012,0.0285424,0.03784013,0.0040065576,-0.038672816,0.05588058,0.07485486,0.062741175,-0.038055804,0.031712517,0.012909755,-0.021013064,0.029585632,-0.027053513,-0.08064285,-0.047206618,0.019501511,-0.011316637,-0.113441646,0.09126143,0.005770838,-0.06318664,0.07603181,0.10098671,0.03869214,-0.03570932,-0.04609767,0.03481597,-0.025911372,-0.14892906,-0.016117552,0.011141884,0.087528035,0.07305928,0.011667597,-0.05100005,-0.017532595,-0.009805286,0.010049251,0.0035770612,-0.010824851,0.08654442,-0.04295718,-0.027823525,0.028027952,0.07053963,0.020851826,0.014741046,-0.0085560735,-0.07802549,0.007968872,-0.03238616,-0.026055126,0.11700232,-0.03395055,0.032491684,-0.00710394,-0.010201751,0.08489161,-0.07347819,-0.012290067,0.007844434,-0.0593098,0.051388964,0.06192061,-0.040643115,0.02034088,0.07902099,-0.016030971,0.010201005,-0.04858406,0.0007675267,0.057654794,-0.015795466,-0.0076983087,0.03236386,0.028940497,0.011907465,-0.020697044,-0.031497538,0.04816617,0.038286623,-0.0026968932,-0.010767451,0.007974161,0.006350436,-0.07433219,0.082551256,-0.031731702,-0.063171335,-0.020297466,-0.008821079,-0.019361129,0.041495703,-0.041160427,0.007463323,0.022724628,-0.022107927,-0.009449347,-0.059237853,-0.05974507,0.13718273,0.009054365,0.020971335,0.018079782,-0.0015169545,0.042240616,0.03847928,-0.001114663,0.087315135,0.012789447,-0.0392787,3.7905204e-34,0.023914797,0.012298364,-0.038645454,-0.030577863,0.09039376,0.01843557,0.042002026,-0.0085208295,-0.080403164,0.028146898,-0.1259359,-0.07076394,-0.07234431,0.009701878,0.0017840223,0.07059057,0.014387103,-0.048165996,0.03923733,0.011628245,0.079896815,0.085705444,0.016386686,-0.033905167,0.029629411,0.06521108,-0.028831469,-0.020672232,0.07393667,0.021517633,0.118012786,-0.041083604,-0.07257656,-0.024099816,0.031901177,0.021234069,-0.051372994,0.013090495,-0.01779555,-0.019753756,0.03165689,0.01738918,0.06568384,-0.06767009,0.047588978,-0.011974093,-0.008954251,0.06885905,0.030744728,-0.015217968,0.11033021,-0.018178662,0.073736176,-0.022423303,-0.02346254,-0.05829072,-0.014501203,0.0169131,0.012726973,0.11901633,0.06481472,0.11406675,0.047866974,0.021587314,0.08404249,-0.09308666,-0.046811085,-0.020477913,-0.030652497,-0.06369457,-0.017232718,0.006725019,-0.015629843,-0.019476349,0.032091543,-0.06762358,-0.038849,-0.05479114,-0.010355948,-0.057420958,-0.036154937,-0.053643953,0.08414725,0.008527118,-0.050059166,0.028536228,-0.07472626,-0.00022006885,-0.00919539,0.036852125,-0.055291113,-0.019885935,-0.12807366,0.069837436,-0.0026422048,-1.8085963e-33,0.042510163,0.0033925197,0.06486413,-0.045390297,-0.05589193,0.13970284,-0.0653321,0.06929203,-0.05421755,0.01847973,0.02673248,-0.00019359942,-0.007942614,-0.016074788,0.0047189253,0.036893018,0.049041465,0.069860965,-0.015624367,-0.051041003,-0.0927638,0.022139871,-0.02447573,-0.067550145,0.04609544,-0.05945093,0.09849283,0.0106510995,-0.110613115,0.016721768,0.04347236,0.035476875,-0.049314965,-0.07715046,-0.042605493,0.021892307,-0.089571066,-0.121762365,0.062771924,0.0015739998,0.034503374,-0.044334643,-0.0050426023,0.074390434,-0.0040307264,-0.008587762,-0.07678529,0.007945877,0.0095842,-0.020797553,0.023234611,-0.06176344,0.08350254,-0.031239152,0.057501566,-0.02627152,-0.0455813,0.043783948,-0.0074248915,-0.011054598,-0.012800847,0.023592798,-0.07883014,0.026743695,0.13745369,0.11644188,-0.0951456,0.024593916,0.004784177,-0.011245272,0.02923193,0.039302085,-0.043428324,0.036777545,-0.017303025,0.039941184,0.01099466,-0.031163823,0.007177917,-0.005678296,0.040445503,-0.10546296,0.05584134,-0.10600006,0.016565127,-0.058058616,0.065102726,0.03660756,0.003599875,0.039751973,-0.0056362203,0.045966495,-0.093106754,-0.01243193,0.08393177,-1.9189198e-08,0.09772988,-0.021391947,-0.06426392,-0.056261715,-0.04971654,6.70484e-05,0.016389016,0.03264082,0.015139945,0.05268428,-0.063002534,0.018078772,0.0016331184,0.031319343,0.022907712,0.025718901,0.00014413787,0.0025568616,0.0122326305,-0.005301404,-0.048347186,-0.0055275303,-0.027555164,0.01666766,-0.032132987,-0.067161985,0.0747702,-0.06562985,0.05006967,0.031965718,0.044282675,-0.0061268914,-0.032604083,-0.065832034,-0.031374026,0.0041706013,-0.09631555,-0.07501559,0.042438198,-0.04535762,0.021103416,0.0073887655,-0.040870927,-0.032307263,-0.09433074,-0.04180156,-0.06893141,0.061359353,-0.020737277,-0.050523676,0.017683623,0.03972051,0.015133278,-0.024694672,-0.066875026,-0.009000721,0.084464,-0.03007169,-0.021799028,-0.015211434,-0.056149863,-0.050938644,0.09313764,0.05302997 +4.2.3.221,"Isolated from Macrophomina phaseolina, a pathogenic fungus that causes damping off, seedling blight, collar rot, stem rot, charcoal rot, basal stem rot, and root rot on many plant species. The 22-membered ring in macrophomene represents the largest macrocycle discovered in terpenes so far.",384,0.99999994,0.013400048,-0.017645152,-0.029041212,0.015558822,0.042505536,0.0037576647,-0.07831239,0.103840254,0.07149802,0.008430054,0.03564322,-0.023487315,0.012310707,-0.005869781,-0.09324095,0.017589185,-0.050145775,0.034230392,0.008714271,0.03523849,0.0284938,0.10418914,-0.025716558,0.044148374,-0.043137114,0.02450928,-0.004315798,0.04726481,0.015623631,-0.09945457,-0.086058594,0.12784617,-0.098786175,-0.02768123,0.06283941,0.050378338,-0.091755636,0.060759526,0.081150725,-0.052785102,0.057693455,-0.051082812,0.04665496,-0.08739518,-0.0040961606,0.04881384,-0.052513774,0.059772484,0.060275268,-0.03739182,0.010311647,-0.042218674,0.0146694705,0.11231747,0.022782842,-0.027236218,0.03588919,-0.04936716,0.010926839,0.012073412,0.05066984,-0.00090991514,-0.0030523348,-0.034275066,-0.06619755,0.015474734,0.0027247202,0.008403142,0.017832099,-0.009399168,-0.006286425,-0.0056833113,0.0021153328,0.08238058,0.031274248,0.12951112,-0.0021291191,-0.05145642,-0.033456914,-0.0634559,0.0385828,-0.008751228,0.067866325,0.040915217,0.04169973,-0.053330142,0.043978576,0.0015688253,0.052884266,0.07326096,0.03230383,0.1447436,0.07938263,-0.025905082,-0.056600403,0.06716224,0.08391799,0.017974982,0.00090683164,-0.0021461984,0.0027445757,-0.05845901,-0.019553384,-0.0571132,-0.025719851,0.024161,0.02992279,-0.10295923,0.08875486,-0.041917413,-0.010733076,0.026824944,-0.0070082215,-0.11377981,0.005918678,-0.04509967,0.09104606,-0.011961747,-0.013627141,-0.0170456,0.022308327,0.015480316,-0.019068105,-0.011474672,-0.018443972,0.04055156,-0.062068615,1.623424e-33,0.05311844,0.033417426,-0.05529209,-0.0069781686,0.016766392,-0.00987209,-0.010493728,-0.017598238,0.004250741,-0.09245847,-0.063328125,-0.039337113,-0.047629394,-0.026816016,-0.0187542,-0.02067481,0.024061173,0.00046954537,0.028342364,-0.028158309,-0.0069861496,0.02800296,-0.036157656,-0.054553635,-0.00047452247,0.038395077,0.03358357,-0.053854026,-0.00088459684,-0.00088209833,0.029679691,-0.036453255,-0.07824882,-0.0081557715,0.06666643,-0.01943581,-0.022061046,-0.009428572,-0.10896256,0.0416472,-0.04833025,-0.01948054,-0.026798928,-0.076486096,0.06542325,-0.044244513,-0.05457331,0.070871666,0.018803038,0.015229544,0.04521426,-0.0010710283,0.032673087,0.021512076,-0.020225229,-0.01712712,-0.006743854,-0.07349609,-0.0017765771,0.0022118615,0.0406985,0.057452485,-0.09268641,0.04082671,-0.012501952,-0.006901707,-0.118710995,0.01795319,-0.06929659,0.02224689,-0.021027753,0.0033772734,0.025048897,-0.018630238,-0.0022756944,0.0050751814,-0.06290242,0.009176079,-0.024162766,-0.021755263,-0.02568507,-0.07122155,0.0089733815,-0.04004112,-0.09187953,0.05549954,0.06919795,0.004314153,-0.044675216,0.010397279,0.07053693,-0.029582346,0.010517728,0.061811127,-0.047709655,-2.4472239e-33,0.047502242,-0.029720701,0.027737776,0.044075865,-0.0068338206,0.055614267,-0.078101434,0.011356092,-0.062351253,-0.082564056,0.04337325,0.009501916,0.012049118,0.027882816,0.04913935,-0.028084634,0.0718214,0.054869626,0.04450227,-0.10057932,-0.04839016,0.03420386,-0.07305431,0.091337085,-0.012472896,8.5612905e-05,-0.007848366,0.06621654,-0.021375509,0.08235323,0.0273881,0.07649474,0.045127057,0.05266902,-0.043509863,0.08738742,-0.058027282,-0.12093693,0.07612419,0.06903202,-0.007545474,-0.05910386,-0.05749324,-0.0006295318,0.03628233,0.039080445,-0.037313044,0.05742065,0.084223576,0.0070713246,0.09844598,0.013466076,0.018431596,-0.031141125,0.029145496,-0.0058711013,-0.0020441401,0.046733167,0.05446334,0.029203257,-0.0013942248,0.011512539,-0.02905184,-0.009790397,0.035758752,0.05702299,-0.020123497,-0.018300984,0.024017366,0.013780621,0.0359731,0.11971943,-0.013688064,0.014658519,-0.03113369,0.060763072,0.041678596,-0.037675828,-0.047364365,-0.01871311,-0.018233959,0.00849388,0.07479295,-0.08872797,-0.07291934,-0.07757047,-0.016775643,0.025278358,-0.02911048,-0.013481471,-0.01490689,0.018359585,-0.065316856,0.062985614,0.11481605,-3.4703245e-08,0.10050912,0.037607245,-0.019277304,-0.07774299,0.026213722,-0.0465033,0.09604642,0.029775636,0.050339438,-0.01318668,-0.06629407,0.019227222,0.04311546,0.050917603,0.11482133,0.0069933506,-0.04320913,-0.06603815,-0.072975986,-0.063081086,-0.038325313,-0.042487133,-0.06078497,-0.048504565,-0.037756972,-0.09615875,0.069142886,0.026764276,0.0029980906,-0.03550355,0.011628347,0.0098493695,-0.052101143,-0.011309976,-0.077759795,0.09075387,-0.0691331,-0.05312868,0.026274247,0.044766456,-0.054941982,-0.053921152,-0.14104842,-0.04552257,-0.073935926,-0.05059819,-0.029857334,0.06658143,-0.042719107,-0.038904794,0.0071521816,0.07615952,0.03409796,0.025812339,-0.033926975,0.013985409,0.07505854,0.03520302,-0.0050867177,-0.0849152,-0.08076761,-0.04751655,0.11323633,0.025799993 +4.2.3.222,"A diterpene synthase from the fungus Diaporthe amygdali. Phomopsene synthase has also been isolated from the bacteria Nocardia testacea, Nocardia rhamnosiphila and Allokutzneria albata. The Allokutzneria albata enzyme also generates allokutznerene (EC 4.2.3.224, allokutznerene synthase) and traces of (-)-spiroviolene (EC 4.2.3.158, (-)-spiroviolene synthase).",384,1.0,-0.022676164,-0.011148324,-0.12361198,0.04709862,0.040899195,0.027953297,-0.11145506,-0.038069736,0.055025507,-0.008637604,0.071441405,-0.01098271,-0.051796045,0.019482542,-0.093249366,0.07090781,-0.120534495,-0.0092451135,0.0414625,0.05616189,0.02043167,0.07654245,0.023888705,0.032169104,-0.012038673,0.07470969,0.016459746,-0.050675,0.018075107,-0.08577933,-0.012082179,0.013507549,0.06938775,0.012684173,0.040060736,0.010927273,-0.009091743,0.031770587,0.047442347,0.076474994,0.027558424,-0.011233094,0.0041970722,-0.04214851,-0.029480308,-0.03840963,-0.060830213,-0.0054680123,0.03000014,-0.06671803,-0.073433906,-0.06357238,0.024112374,-0.036606316,0.0911368,-0.008856152,-0.017807778,-0.07110416,-0.024885189,0.022810534,0.05108022,0.060576472,-0.01053577,-0.04262111,-0.03144654,-0.028646786,-0.030285535,-0.02193053,0.012301422,-0.058042143,-0.119374976,-0.06827779,-0.003534312,0.050359923,0.046667967,0.0763901,-0.036529753,0.034331623,0.021914132,0.01369365,0.04329916,-0.05458415,-0.017590685,0.012546872,0.027827645,0.03234154,0.011539259,0.07046596,0.09468259,0.025911896,0.0049151173,-0.014924322,-0.027958121,0.012450271,-0.111749254,0.06231257,-0.012978506,0.04441245,0.024781074,-0.057612274,0.045247518,-0.06825283,-0.007418012,-0.07075583,-0.043873053,-0.003196073,0.07583969,-0.02919122,0.06984776,-0.006040666,-0.025726905,0.031868905,0.03681948,0.011200628,-0.010267362,-0.034257147,-0.009322564,-0.06368419,-0.0144263925,0.023742124,-0.010693575,-0.014006854,0.061325204,0.020980697,-0.006552518,0.053185783,-0.13268757,3.97153e-33,0.077250525,0.08995199,0.062762275,0.0034338478,0.04689716,-0.03576665,-0.035098646,0.076115526,-0.02981574,-0.1217713,-0.09318539,-0.026188971,-0.06829622,0.051447343,0.004586413,0.008951213,0.020417262,-0.021527428,0.09513352,-0.01381607,-0.001349525,-0.0039017391,-0.10361881,-0.019150874,0.06176169,0.044949133,0.0042335214,-0.038961064,0.07380341,-0.04874786,-0.00022873968,-0.08686049,-0.0386275,-0.020403324,0.042306576,0.004157189,0.008526994,0.0136821745,-0.09670416,0.017150296,0.012100827,-0.008826914,-0.050635092,0.01686422,0.040957868,0.045960117,-0.05747265,0.08774778,0.07482619,0.040962677,-0.0026771904,-0.01301952,0.017911375,-0.017589241,-0.105884634,0.013435771,-0.0013734433,-0.022115545,0.07927547,0.016312474,-0.07612643,0.07327663,-0.0578517,-0.04938775,-0.018813575,0.009218114,-0.043241918,-0.08208526,-0.035466213,0.05641739,-0.046433453,-0.0419196,-0.014353079,-0.022965463,0.030003924,-0.03202032,-0.16273259,0.009667874,0.039530855,-0.068562284,0.01610222,0.012849328,0.03050963,-0.0064801914,-0.009655356,-0.016630221,-0.021992682,0.07163686,-0.015493209,0.06721947,0.0776846,-0.043913018,-0.018761005,-0.050786145,0.027554482,-3.573778e-33,0.062203463,-0.11000672,0.017639322,-0.027703864,0.014700485,0.06902912,-0.02536463,0.024870306,0.044919103,-0.066704,0.072427794,-0.007872693,0.11598185,-0.045114376,-0.025013128,0.02492971,0.025684725,0.1176544,0.033476412,-0.05678631,-0.009978501,0.05886887,-0.010630577,-0.012345928,-0.06333784,0.041456763,0.09567088,0.10660051,-0.036134277,0.04757788,0.042819735,0.006189857,-0.025083484,-0.04106455,-0.048453957,0.06035,-0.10214131,0.023350954,-0.010336373,0.014543498,-0.035621613,-0.014208805,-0.0074764364,0.06739932,0.080696695,0.023102807,-0.03250395,-0.041469987,-0.014158993,0.009291712,0.0679536,0.013942283,0.023447141,-0.010205018,0.012062708,0.031145627,0.009484232,0.003977503,0.009140897,-0.040302053,-0.054667953,-0.03214652,-0.050252847,0.0049813064,0.045658458,0.056999512,-0.03012552,0.08789836,0.042956207,-0.03734946,0.024351336,0.080195926,-0.021826334,0.08376503,-0.019900844,0.05876528,-0.036856458,-0.052584022,0.032690186,0.0496812,-0.045479532,-0.013803915,0.046202306,-0.05935828,-0.07843753,-0.04556731,0.1330989,-0.007108662,-0.053407513,0.04721881,0.02235882,0.04481954,-0.059691545,0.05559938,0.049785707,-3.6439445e-08,0.014589191,-0.08545221,0.011324341,-0.06158268,0.00390424,-0.069647826,0.089404225,-0.0059127226,0.03902891,0.0003534206,0.011786976,0.0073366542,0.01175993,0.07001569,0.1066766,-0.004228444,0.04055591,0.05221054,-0.024794437,-0.0056470204,0.016713148,0.03312392,-0.0779951,-0.0042147846,0.06362431,-0.085317865,0.040200777,-0.028010346,0.010096749,-0.0050317817,0.030936038,0.0053553623,0.024431044,-0.015950143,-0.042150803,-0.034451347,-0.015486736,-0.08699748,0.013250527,0.0076864976,0.018317508,-0.073304504,-0.07507925,-0.016708551,-0.046557438,-0.02434472,-0.016610404,-0.04455111,0.04740178,0.00522723,0.042427048,0.051884834,0.017509095,-0.05279652,-0.07299918,-0.03228416,0.0039935797,0.040576413,-0.07006264,-0.10700594,-0.012264021,0.021596037,0.1930538,0.09839304 +4.2.3.223,A diterpene synthase isolated from the bacterium Allokutzneria albata. 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+4.2.3.224,"A diterpene synthase isolated from the bacterium Allokutzneria albata. It also produces phomopsene (EC 4.2.3.222, phomopsene synthase) and traces of (-)-spiroviolene (EC 4.2.3.158, (-)-spiroviolene synthase). 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+4.2.3.225,A diterpene synthase isolated from the bacterium Streptantibioticus cattleyicolor.,384,1.0,-0.044500027,-0.07533574,-0.09264214,0.068271115,-0.041258853,0.009983683,-0.057616174,0.03925649,0.11182696,-0.02316429,-0.009267849,-0.0687284,0.033406742,-0.036231905,-0.061867207,-0.015039114,-0.045577094,-0.0040816003,0.05540292,-0.0081834085,0.06480273,0.08283801,-0.044871017,0.018131323,0.057209775,0.017485766,0.06943057,-0.033129007,-0.022693217,-0.074864015,-0.018182702,-0.030308561,0.024879446,-0.09607986,0.072790295,0.0029172993,0.023398941,-0.020703292,0.17052671,-0.0022511706,0.035060637,0.023749005,0.0985032,-0.03461514,-0.028465346,0.033827215,0.019795965,0.08224582,0.037172735,-0.073622525,-0.033156186,-0.062908165,-0.03995017,0.02662382,0.047223117,-0.012666928,0.06620367,-0.013950238,0.00063634594,0.009243249,0.06267054,0.0776578,0.06686206,-0.04089422,-0.089337826,-0.018942898,0.019491306,-0.012071502,0.034044173,-0.07846644,-0.11482047,-0.020757884,-0.019856667,-0.025563644,-0.02545368,0.09104472,0.0070343497,0.063940756,0.020365085,-0.021145983,0.08055521,0.011613624,-0.020053163,0.08012306,0.055564336,0.011644735,0.028587418,0.008609367,0.079179145,-0.01659234,-0.01922817,-0.016671149,-0.060385477,-0.04979042,-0.0796807,-0.026435493,-0.018270195,0.05159432,0.03234934,-0.023137448,0.013255284,-0.042420004,-0.0143153,-0.0556335,-0.070298865,-0.01221656,-0.035050638,0.018833287,0.048726395,-0.05522754,0.019230913,0.03175045,-0.01288472,0.03818007,0.020161875,0.036038272,0.049834933,-0.11624157,-0.054307405,0.011406924,0.04705441,0.023332682,0.07620571,0.054778393,-0.029453766,-0.01790726,0.025679426,3.1306335e-34,0.026570115,0.029913172,0.05335262,-0.015422081,0.039355624,0.018879818,-0.10348605,0.05682716,-0.05063988,-0.107736655,-0.044963516,-0.078118354,0.005749236,0.055091962,0.03873899,-0.027934926,0.04467305,0.04989146,0.047123365,-0.05793263,-0.014000408,0.08636741,-0.010154791,-0.038603645,0.05140149,0.019837927,0.012925607,-0.031341057,0.14230344,-0.04004697,-0.0098242145,-0.12741989,-0.026398275,-0.03655935,0.013207608,-0.04358447,-0.05458582,-0.05698822,-0.0014939081,0.018831255,0.014295916,0.06699592,-0.010675462,0.016894516,0.080434516,0.091159075,-0.031681675,0.029282093,0.022418039,-0.03724983,-0.029567715,0.009420075,0.07146527,-0.03505901,-0.07718309,0.019456973,0.017695677,0.0025534239,0.038734604,0.047691394,-0.0030086061,0.13544486,-0.09223209,-0.008055081,-0.010424004,0.06910686,-0.015535408,-0.021536076,0.049191248,0.098809026,-0.08580535,-0.049989276,0.008931872,-0.03891392,0.029016795,-0.0042266697,-0.08517042,0.007005934,0.05460107,-0.03560729,-0.022109166,-0.01725576,-0.0600811,-0.05945557,-0.062178858,-0.003743311,-0.061517183,0.041121174,-0.027840026,0.069308266,0.039430186,-0.067337304,-0.09918497,0.008792705,0.045628987,-1.3455414e-33,0.036402408,-0.09313073,0.07913078,-0.0097428225,-0.050252046,0.049910065,-0.067920156,0.02461262,0.032281235,-0.034844022,0.03366541,0.008454549,0.028440379,0.021340508,-0.0083404435,-0.03331827,0.019182688,0.10627483,-0.0013593524,-0.03275612,0.03679574,0.018515581,0.0062748264,-0.02188105,-0.010961091,0.030978216,-0.014033192,0.078734174,0.012359015,0.031546768,0.024291059,-0.02915681,-0.03338563,-0.069615796,-0.13993104,0.020583263,-0.039984126,-6.3360705e-05,0.011174534,0.06340627,-0.0024114589,0.015757134,-0.0013280759,0.069010004,0.0371358,0.03209601,-0.14735112,0.043054063,0.013983323,0.033379786,0.053393874,-0.00041342177,0.0031401615,-0.050243065,0.0197307,-0.035434805,0.0040080557,0.0054239267,0.02818551,-0.020001436,-0.025050439,-0.029615145,-0.009751851,-0.05773879,0.012298535,-0.008869558,-0.005524685,0.03626953,0.09536603,-0.065194905,0.07025009,0.05847594,-0.014042824,0.04240978,0.035509758,0.07219006,-0.039627295,-0.0829118,0.02923568,0.013972667,-0.031444862,-0.090953626,0.04648779,-0.02999693,-0.013365346,-0.03741385,0.04890663,0.100734405,0.0863993,0.05867892,0.0001636815,0.026896086,0.005056605,0.040509064,0.055013366,-2.0988113e-08,0.016795628,-0.058020186,0.045425653,-0.009690103,-0.02749962,-0.027746046,0.010012995,-0.061026234,0.042397875,0.0031469879,-0.012110664,-0.01649069,-0.048095826,0.034111567,0.008342358,0.054256134,-0.0031048255,-0.10124879,0.01680723,0.037406415,-0.03423155,-0.013198753,-0.0914274,-0.0037114846,0.039847877,-0.16324037,0.018419143,0.0063289856,-0.036428437,-0.00034659228,0.011545895,0.047432963,-0.025008103,-0.034702063,-0.050566494,-0.021147424,-0.076674916,-0.016849635,0.018422356,0.05173778,-0.009404152,0.0216742,-0.03865168,-0.013011357,-0.05539437,0.023407947,0.0069029806,-0.0059912824,-0.049002893,-0.041351445,0.005078351,0.020184288,0.02390821,-0.006683721,-0.097328834,-0.013401252,-0.01607019,-0.012635743,-0.087971605,-0.04602309,-0.013612027,-0.058186863,0.21580763,0.085057236 +4.2.3.226,"The enzyme occurs in plants. The initial cyclization product is a (7R)-beta-bisabolyl cation. The major final product is (+)-2-epi-prezizaene. Other products are (-)-alpha-cedrene (cf. EC 4.2.3.227, (-)-alpha-cedrene synthase), small amounts of (-)-beta-curcumene, and other sesquiterpenes with less than 10% yield. The enzyme also catalyses the reaction of EC 4.2.3.61, 5-epiaristolochene synthase.",384,1.0,-0.029003313,0.026234318,-0.06820249,-0.0031165618,0.037801836,0.059595585,-0.029748315,0.028679378,0.0694259,0.01336324,0.030640729,-0.07787745,0.0004158073,-0.038608197,-0.106371306,0.024984727,-0.037627432,0.02651342,-0.012055722,-0.051288288,0.028502773,0.0072489255,0.016600933,0.07373013,0.06486133,-0.0053856494,0.016529381,-0.04335006,-0.0018771442,-0.078566924,0.029902566,0.005061226,0.11555599,-0.01591035,-0.0074328915,0.05535462,-0.07407373,-0.06485447,0.03376103,0.03357141,0.050106395,-0.040131476,-0.038397133,-0.05992281,-0.01244527,-0.03180951,0.026282562,0.037271984,0.030699337,-0.053071346,0.027869802,-0.10628791,-0.064391516,-0.007515225,-0.002014944,-0.032264046,-0.025044473,0.012685423,-0.025925033,0.0718542,0.11121934,0.016819846,-0.050890137,0.014650317,-0.05731158,-0.007985285,-0.008342395,-0.08568245,0.012277562,-0.027638063,-0.06514822,-0.04438075,-0.028151281,0.05432213,0.004361581,0.06266311,0.027008258,-0.015718661,0.015132615,-0.039781246,0.01710781,0.010123137,0.01539325,0.011283824,0.0636185,0.07643504,0.011298262,0.021267228,0.076750055,0.02627974,0.10562402,0.052130166,-0.06465505,0.03254968,-0.04512753,0.10129923,0.063582845,-0.0065729627,0.100513816,-0.03274967,0.012902226,0.041470647,-0.026958391,-0.074499056,-0.057893075,0.03525083,-0.008639294,0.015137063,-0.033885732,-0.02701971,-0.003872727,-0.07710438,0.02789615,-0.014219753,-0.048657067,0.1316298,0.029289521,-0.04097049,0.055074897,0.007880466,0.010198232,0.015087668,0.0035155027,0.09640949,-0.05501718,0.07001765,-0.071414545,3.313725e-34,0.028144319,0.07202539,0.0011455712,0.0613857,-0.016776344,0.03721266,-0.040597413,0.06755919,-0.09724097,-0.09159843,-0.06991632,-0.043590102,0.031758886,0.023650682,0.0109815,-0.033542164,0.0302185,0.010933969,0.04121572,-0.07661014,-0.024834253,0.02135231,-0.1008033,0.025040394,0.001777494,0.016031222,0.040009838,-0.009580444,0.0662478,-0.03881773,-0.04006291,-0.050174814,-0.060076058,-0.015815606,-0.0060915234,0.044517577,0.013830296,0.005264666,-0.044107392,0.10851455,0.015135982,0.022592328,0.008469021,-0.02816326,0.06922207,-0.060482446,-0.088111155,0.05583152,0.1363959,0.017069897,0.05646928,0.049633306,0.0820663,0.03306781,-0.103230976,0.05481791,-0.034685086,-0.03423292,0.04163686,0.023696812,-0.024305066,0.08199469,-0.053733043,-0.027632283,0.0066743754,0.033558387,-0.052124266,-0.025408057,-0.0735118,0.06338039,-0.071670674,-0.056505222,0.08226739,0.01047483,0.111612216,0.034778833,-0.12429693,-0.015554611,0.04074729,-0.0034237416,-0.07217382,0.046884026,-0.0064737294,-0.02994424,-0.03179051,-0.029215844,-0.03944072,0.03949941,-0.0021220816,0.10278947,0.06813031,-0.0770061,-0.06697872,0.06663844,-0.013595187,-6.5755405e-34,0.08365005,-0.091344506,0.027624065,-0.037546717,-0.025763484,0.022767838,-0.046546295,-0.08267538,0.015925901,0.0013301341,0.09073979,-0.060580533,0.11572227,-0.015134697,-0.018972874,-0.019904299,-0.0023586915,0.121725686,-0.029033074,0.022415476,0.04278521,0.0153837195,0.0418603,0.0070383805,0.022826027,-0.03992013,0.0580255,0.033924967,0.07145093,0.026955176,-0.014835731,-0.078431144,-0.03769867,0.05436216,-0.09434074,0.06540996,-0.0919663,-0.032841768,0.047238212,0.04715671,-0.029508978,-0.041219328,-0.0024096929,0.062107436,0.12745577,0.034782566,-0.02779661,0.063355036,0.009617902,-0.0020918816,0.0346126,0.03933245,-0.012644797,0.006431225,0.029617924,0.035566986,-0.012926217,-0.0028191437,0.004083325,-0.042914834,0.022166586,-0.033839844,0.0059175226,-0.038752493,0.037379608,0.05032946,-0.08099859,0.11849579,0.009028717,-0.02830746,0.072562434,-0.0024620795,-0.06919882,0.018728182,-0.033235632,-0.022459174,0.01767612,-0.07611871,0.016928215,-0.05659547,-0.050480206,0.00015872296,0.07260546,-0.051713068,-0.04483361,-0.044886906,0.035466924,0.05818965,0.04864831,0.05225385,-0.040589947,0.029922893,-0.032047246,0.065243855,0.1375667,-4.4708315e-08,-0.023621323,-0.06876367,0.034676045,-0.061343804,0.009683029,-0.029251015,0.054981034,-0.024695113,0.0282834,-0.072524436,-0.07136601,0.03622028,0.00054619357,0.02849893,0.042024724,0.04088771,0.022034276,0.0024841926,0.012861126,-0.025065802,-0.028262248,-0.007910109,-0.045896973,-0.015429874,-0.01594534,-0.13399887,0.035140343,0.09642441,-0.050574496,-0.0072460305,0.009292478,-0.014998699,0.0125904875,0.008504157,0.010683443,0.046059415,-0.016168835,-0.036351293,0.008141463,0.008268907,-0.009372238,-0.10340606,-0.022282109,-0.022240926,-0.010129744,-0.005116835,-0.004373897,-0.020948362,0.030204635,-0.025737066,0.03696549,-0.04907627,0.009728553,-0.07265808,-0.060331397,0.013441551,-0.013575889,-0.03454213,-0.0073911515,-0.0830526,-0.036504142,-0.0069324733,0.18676974,-0.029661644 +4.2.3.227,"The enzyme occurs in plants. The initial cyclization product is a (7R)-beta-bisabolyl cation. (-)-alpha-Cedrene is one of the major products. Other products are (+)-2-epi-prezizaene (cf. EC 4.2.3.226, (+)-2-epi-prezizaene synthase), small amounts of (+)-beta-curcumene, and other sesquiterpenes with less than 10% yield. The enzyme from Nicotiana tabacum (tobacco) also catalyses the reaction of EC 4.2.3.61, 5-epiaristolochene synthase.",384,0.99999994,-0.04379497,0.03698238,-0.08822428,-0.019387696,0.0074362135,0.090578444,-0.038173407,0.023648413,0.08837434,0.04186302,0.04883443,-0.066366754,-0.0027388663,-0.05844347,-0.07752121,-0.022958674,-0.029502168,0.08531772,-0.042987335,-0.04278387,0.046616234,0.005433216,0.055288933,0.043869656,0.044338763,0.012423084,-0.035556607,-0.02520284,0.019010752,-0.06619234,-0.0022191927,0.021732125,0.064818874,-0.022105552,-0.014015577,0.030603856,-0.0841841,-0.07478537,0.046260234,0.02066446,0.042747173,0.010023445,-0.052811127,-0.048157156,-0.044004552,-0.059862353,0.048162397,0.007141816,0.015987929,-0.08437395,-1.8275583e-05,-0.0448559,-0.066606805,-0.047627542,-0.019426035,-0.03837804,-0.03516035,0.007159424,0.014245965,0.0584826,0.09109176,0.0039222366,-0.021358633,0.011282853,-0.04799339,-0.04210118,-0.01109638,-0.067028224,0.037368678,-0.04385099,-0.08085718,-0.04013677,-0.038279492,0.07806253,0.018592708,0.078000546,-0.019533835,0.018293085,0.0068870643,-0.03905315,0.02598856,-0.007141011,-0.013247412,0.06143183,0.05229124,0.07231166,0.016256366,0.043051522,0.12625389,0.013512588,0.11290253,0.0645237,-0.023249274,0.05008839,-0.09034592,0.07726556,0.078458205,0.0047519715,0.071176946,-0.021427277,0.057631392,0.05314193,-0.0037253215,-0.042634796,-0.05795938,0.020924479,-0.005663003,0.012918614,-0.020656817,-0.04861126,0.0063114148,-0.074216045,-0.006976322,-0.054921128,-0.071781285,0.11859092,0.032661837,-0.05364452,0.05543859,-0.007606203,0.005455317,-0.011099857,0.009415867,0.08237156,-0.025523428,0.052416272,-0.11438088,8.245787e-34,0.0014164997,0.09183676,0.020042496,0.054391462,0.027131578,0.032557227,-0.046368062,0.04095155,-0.07054306,-0.078405865,-0.090291135,-0.022647725,-0.004053394,-0.000502626,0.0013206571,-0.0003501217,-0.015400233,-0.020278087,0.054659117,-0.06218306,-0.027239533,-0.034681443,-0.07879486,0.03777316,0.0038564776,0.02031359,0.011709361,-0.029204808,0.054329675,-0.03281999,-0.004092372,-0.029429832,-0.063181475,-0.08261263,0.026578723,0.06272811,0.020844217,0.02987635,-0.053472534,0.09141385,0.013783986,0.036400393,0.029906532,-0.020213623,0.034192592,-0.09037454,-0.11133573,0.06874483,0.14975633,0.012545482,0.046458744,-0.0024279584,0.116013594,0.032154743,-0.120316364,0.070834525,0.0076905726,-0.011039159,0.0038565134,0.0643139,-0.045096323,0.076878436,-0.039328642,0.0016628673,-0.020254476,0.03556362,-0.05067164,-0.0498669,-0.025822256,0.0683817,-0.07031548,-0.049977954,0.074735254,-0.0036449535,0.109612,0.009214567,-0.123652525,-0.010916877,0.027745163,0.036984157,-0.07066024,0.030389976,-0.03211814,-0.029391922,-0.035773266,-0.045003895,-0.018721022,0.030702801,0.026922654,0.11628791,0.08112635,-0.033559423,-0.024059841,0.06674882,0.003319256,-1.3015396e-33,0.04903939,-0.058615167,0.06311673,-0.048899557,-0.0037807361,0.023639826,-0.034520175,-0.07553423,0.0014481521,-0.0023792984,0.07600877,-0.052819427,0.12584153,0.014995701,-0.03316646,-0.0021671627,0.0075968555,0.11002038,-0.001563516,0.028488617,0.0037923125,0.022848312,0.028527219,0.026029628,0.0195863,-0.053618412,0.07004852,0.023466535,0.03786378,-0.006279424,0.01603176,-0.05611598,-0.0628891,0.039461162,-0.08970594,0.0402293,-0.06393507,-0.016956143,0.033561938,0.026675496,-0.0250984,-0.0398777,0.006931648,0.06701687,0.105832115,0.0026046478,-0.012158612,0.05789417,-0.0291643,0.045154426,0.03681843,0.024967771,-0.0394754,0.028547192,0.06540692,0.04472501,-0.032718502,0.018100945,-0.014199799,-0.033571977,0.0137332175,-0.039843604,-0.035569105,-0.021731157,0.059966266,0.051081292,-0.07081896,0.10524602,0.04132619,-0.05157919,0.07949283,0.007081887,-0.04569901,0.0120039275,-0.013482023,-0.0006943583,-0.0072850105,-0.08817734,-0.00042999513,-0.087221146,-0.04161145,0.034227785,0.03701512,-0.078419484,-0.07658445,-0.024061183,0.029684233,0.076010436,0.015521152,0.05339725,-0.025847359,-0.012495654,-0.02611391,0.07471879,0.09220758,-4.3426255e-08,-0.046494644,-0.07390331,0.009386411,-0.036510367,0.009786995,-0.02726412,0.057717793,-0.011190595,0.040252853,-0.06978212,-0.028855132,0.06245819,0.022149198,0.048000477,0.025209457,0.06648887,0.008089654,0.03279723,0.0042660865,0.008053306,-0.031204347,0.030919828,-0.027566485,-0.010825353,-0.014613751,-0.13752818,0.0020532964,0.074571565,-0.037963122,-0.018779961,0.025791684,-0.04252305,0.017031558,-0.011778041,-0.027534738,-0.0050006243,-0.0035883698,-0.0642825,-0.011218666,-0.014236974,0.01836003,-0.10703946,-0.059014462,-0.025161989,-0.022306988,0.00096685276,-0.025316022,0.010723518,0.035481412,-0.011736803,0.019294154,-0.013540897,0.033502467,-0.1140374,-0.08783284,0.0093877865,0.013049995,0.012809365,0.0057163495,-0.08135673,-0.010419118,-0.02440224,0.18811339,-0.008986493 +4.2.3.228,"The enzyme occurs in flowers (pistillate inflorescences) of Cannabis sativa. The enzyme encoded by CsTPS13PK produces 94% (Z)-beta-ocimene from geranyl diphosphate. cf. EC 4.2.3.106, (E)-beta-ocimene synthase.",384,1.0,-0.028564248,0.0063022273,-0.12026715,0.007889984,0.044604015,0.045771603,-0.0027912788,0.010046468,0.07742465,-0.015138087,0.020447453,-0.013993057,0.017941156,-0.024198575,-0.07671247,0.0020726924,-0.02763013,-0.011579887,-0.020806689,-0.01619871,0.032686587,0.0417691,0.052362964,0.020156967,0.03821382,-0.03398978,-0.0049285633,-0.012368701,-0.001346904,-0.07867988,0.021562241,0.06760523,0.04735009,-0.016988805,0.06606977,-0.04673641,-0.026958272,-0.0845099,0.058404975,-0.0057570534,0.07890477,0.016900387,-0.053112563,0.022121737,-0.014060183,0.047032878,0.020289442,-0.027371984,0.014480174,-0.0056855604,-0.038420483,-0.1054711,0.0016269204,0.07402264,0.02544808,-0.06255637,-0.023867257,0.058398467,0.017817937,0.13250451,0.029595543,0.026083838,-0.034171414,-0.022832362,0.05503148,-0.017416524,-0.06728238,-0.04467437,0.02367045,-0.118385725,-0.029702995,0.0064088944,-0.036249284,0.016678449,-0.04678296,0.09574105,-0.038365696,-0.016573053,-0.025400983,-0.044087984,0.050871663,-0.006234153,-0.010447799,0.07735256,0.07461773,0.040218975,0.022524644,0.091611944,0.023957808,0.041549172,0.046954885,0.026406448,-0.099911176,-0.013920968,-0.06820498,0.018568696,0.08366469,-0.053981584,0.032725412,-0.009012224,0.048709672,0.07753789,0.0664143,-0.12501064,-0.074741445,0.04368224,0.013388395,0.010583281,0.011883297,-0.0032930376,0.019390933,-0.04476467,0.036030535,-0.030964967,-0.10480739,0.070605755,-0.059227873,-0.01589162,-0.078167744,-0.03273392,-0.026952147,-0.038290218,-0.040324572,0.10848723,-0.03768403,-0.015923353,-0.13947639,1.7374745e-33,-0.0073958193,0.08040861,0.001068058,-0.009452028,-0.0070593324,-0.01931216,-0.018873952,-0.006307903,-0.06522377,-0.09105893,-0.09889438,-0.077437945,-0.011899576,-0.016093418,-0.03405229,-0.06178061,-0.0039360235,-0.018751848,0.07019516,-0.013212196,-0.021134399,0.022956429,-0.1432025,-0.024341768,-0.0009949951,0.056043953,-0.051540382,-0.02838613,0.044001315,-0.02557694,0.06776114,-0.023033893,-0.036408383,0.03480363,0.06289806,-0.03819164,0.05438151,-0.068458416,-0.033102382,0.03435797,0.057804793,0.017405493,0.07846104,0.07900324,0.023108618,-0.0015057207,-0.08680788,0.015814794,0.12964272,0.044955663,-0.027403552,0.023597803,0.11886605,0.019886069,-0.08580739,0.016253458,-0.068697974,-0.0076561947,0.06634744,0.017925419,0.0075580925,0.009808878,-0.07217248,-0.003538082,0.0005216079,-0.018405177,-0.12746379,-0.039977066,0.0068472843,0.12200845,-0.05459088,0.0136448145,0.027963364,0.002528814,0.039202355,0.012458702,-0.038759492,0.07570891,0.054658696,0.0007188283,-0.019836852,-0.045017164,-0.0862199,-0.04159643,-0.072680235,0.022532176,0.034787636,0.040584758,-0.08066338,0.040995207,0.09645188,-0.0706728,-0.0060587716,0.02877767,-0.016241305,-1.6346952e-33,0.069503866,-0.016674483,0.07788278,-0.046746556,-0.03159358,0.063955486,-0.0010038017,-0.06963981,-0.0032029094,0.0088576805,0.044037987,0.0023485152,0.098096326,-0.051297914,-0.022283942,-0.009430193,-0.001836515,0.12134219,0.0040832115,0.039988894,-0.07420992,0.077779345,0.044670336,-0.02631824,-0.012418736,0.03495586,0.071709,0.016497895,0.026629739,0.06563123,-0.020447394,0.043793485,-0.09450789,-0.062583484,-0.10014884,0.012858433,0.022869335,-0.036349658,-0.002103151,0.05640676,-0.023913179,0.023749646,-0.034897096,0.066104256,0.08427127,0.08847309,-0.0086230915,0.057897113,0.020024376,-0.007622129,0.07515591,0.06188671,-0.046709675,1.5054242e-05,0.10192892,-0.02448622,0.011985508,-0.0058516404,-0.08335397,-0.11426626,-0.02594177,0.021724695,-0.004400844,-0.01639079,-0.014130091,0.06352754,0.011637744,0.047225963,0.060933363,0.047054734,0.023885079,0.0150388945,0.007415719,0.039768975,-0.055624317,0.04117367,-0.034334257,-0.03869193,0.013321257,-0.06394697,-0.029749215,0.030781297,-0.010267658,-0.052965406,0.027646855,-0.059559774,-0.003816586,0.06378491,0.056920875,0.03080951,-0.06500538,0.032244384,-0.021061094,0.051843453,0.0762622,-3.669363e-08,-0.009723812,-0.10130467,0.013007264,-0.032207046,0.06595349,0.033068422,0.06884806,0.017612109,0.04184269,-0.033483777,-0.05213863,0.008973224,-0.017376622,-0.05311448,0.08299636,-0.0020811502,0.0441214,0.040748995,-0.012531133,0.023065696,-0.026748877,0.012002015,-0.01270399,0.05130371,-0.039796792,-0.02314379,-0.015450672,0.034735844,-0.050698683,-0.0057581994,0.06811546,-0.009731171,0.007724662,-0.10181227,-0.05574223,0.029042624,0.024794182,-0.01199055,0.0066400818,-0.011980932,0.004915514,-0.069088355,-0.060696963,-0.024696318,-0.05237031,-0.0059711155,0.047112003,-0.006283511,0.031363845,0.0047831438,0.025597235,-0.03330189,-0.0045443815,-0.062373005,-0.08757976,-0.027206719,0.012078649,-0.015761875,-0.0074800346,-0.051428847,-0.035827924,0.044261046,0.19182362,-0.037842404 +4.2.3.229,The enzyme has been shown to occur in castor bean (Ricinus communis) and rice (Oryza sativa). ent-Beyerene is also a product of EC 4.2.3.19 (ent-kaurene synthase) of the moss Physcomitrella patens.,384,0.99999994,-0.11142704,-0.07896461,-0.08539739,0.0030285018,0.02380473,0.060108338,-0.015101437,-0.01188394,-0.006581138,-0.045722514,0.07151846,-0.0013009196,-0.032628268,-0.017548202,-0.07199023,0.014418793,-0.07524601,0.059378184,-0.014027137,-0.098798454,0.051493812,0.009269756,0.05540755,0.04565467,0.029175919,-0.083141685,0.019646859,-0.06195946,-0.020731537,-0.121848494,-0.057215597,-0.032375902,-0.017190428,-0.04953598,0.04381826,0.029979296,0.0057983943,-0.11502822,0.10286611,-0.007854808,0.07168512,-0.064562984,-0.048615776,-0.0022303856,-0.041492302,-0.038052112,-0.03111517,-0.0121075455,0.02019856,-0.028863309,-0.041476995,-0.051731862,0.013030204,-0.052354526,0.053632263,-0.09470183,0.03500821,0.022857927,-0.012934168,0.044441685,0.12789354,0.018764058,-0.014014911,0.0020744968,-0.04356805,-0.013056749,0.0031144393,-0.020185605,-0.00539121,-0.06687098,0.020784423,-0.09108324,-0.08351563,0.046968404,-0.03223688,0.043005683,0.03696616,-0.029649962,0.007799392,0.023915516,0.0063674897,0.023945974,-0.027061218,-0.009204266,0.040283374,-0.010064042,-0.004335879,0.10418477,0.022874247,0.07437778,0.04683308,-0.009772004,-0.05695634,-0.007123033,-0.029784925,0.021984873,-0.011282042,-0.012427808,-0.021495111,-0.03235761,-0.05860615,0.026195195,-0.03669657,-0.059986174,-0.06351485,0.026266893,0.009016703,0.008085693,-0.035868723,0.040323265,0.0011709619,-0.03189405,0.012641764,0.024174443,-0.08483608,0.07850226,-0.006642283,-0.050103884,0.008762098,-0.038897295,0.038028736,0.047856368,0.03366762,0.09393794,-0.013893417,-0.015989434,-0.1253253,2.0046609e-33,0.08003584,0.03767175,0.012119643,-0.025573313,0.003979746,0.008050291,-0.06474124,0.090305395,-0.021380372,-0.06551981,-0.11391604,-0.123486675,0.022593135,-0.040091876,-0.051235646,-0.003261352,-0.009046042,-0.010742655,-0.009846263,0.02774164,-0.0016344084,0.08020037,-0.08716588,0.03507221,-0.02032649,-0.0022492826,-0.013327031,-0.03959439,0.058210634,-0.0075514647,0.09427249,-0.12985143,-0.05454518,0.026020465,0.045284178,-0.0670421,0.063336454,-0.020701787,-0.04486046,0.044652916,0.030660562,0.029575232,0.040704306,0.017674834,0.0426526,-0.0121700615,-0.008809652,0.11032079,0.06632233,-0.013508662,0.0018542312,0.048824787,0.055462435,-0.011834335,0.03444042,0.10674351,0.031168088,-0.017089628,0.041629784,0.04940538,-0.009905238,0.039610025,0.0365355,-0.028308086,-0.0073279007,0.03329349,-0.0891287,-0.026481334,-0.004590211,0.093319416,-0.042343758,-0.057889212,0.023693172,-0.004734561,0.04710206,-0.03793501,-0.06170603,-0.01943227,-0.03551259,0.011490492,0.015038598,-0.024282863,0.028058728,-0.017766578,-0.06912173,-0.0005922957,-0.071230866,-0.0027021212,0.04776688,0.10664772,0.042469326,-0.018153239,-0.08362304,-0.013067629,0.00050207076,-2.3631373e-33,0.09543182,-0.06388744,0.09176462,-0.03231653,-0.06041187,-0.009312617,-0.024016501,0.030709082,0.06270836,0.046898097,0.1095444,-0.05249021,0.07815236,-0.081992865,-0.017110134,0.069921166,0.023558602,0.07592076,0.0025279229,0.013495034,-0.090206824,0.06471305,0.03623699,-0.0040891296,0.043290015,0.030847415,0.025737645,0.08937517,-0.021062868,0.029591216,0.014823524,-0.09924426,-0.004093563,-0.02066561,-0.079941496,0.05877878,0.016561154,-0.040730037,0.0105218515,0.07125937,-0.022411365,0.022431772,0.021900475,0.08128662,0.028798541,-0.016573181,-0.028360687,0.04577332,-0.0064652283,-0.063970074,0.063700445,0.020650895,0.025230749,0.02090676,0.011454338,0.027939213,0.021076292,0.08289447,-0.04635912,0.036206365,0.068850406,-0.050133906,0.042982444,-0.043140817,0.062399704,0.030643404,-0.094736256,0.07220256,0.070779905,0.005621679,-0.0122044375,-0.04600589,-0.00032631122,0.052235276,-0.039983034,0.01979666,-0.07635118,-0.052992012,0.01582804,-0.03301946,-0.01983876,-0.011540402,-0.0447666,-0.022739757,0.021564916,-0.014081513,0.032599628,0.1004024,0.03415424,0.01412858,-0.062547445,0.019656135,-0.023894634,0.10139017,0.10289068,-3.704423e-08,0.042549487,-0.06266838,-0.030931456,0.0036910914,-0.018749287,-0.08064208,-0.021545695,-0.045116473,0.0007532225,-0.05252074,-0.096857235,0.082573086,-0.036974937,0.009003717,0.09014223,-0.04995052,-0.007680809,0.062241133,-0.020673152,0.01560763,-0.011492352,0.020559937,-0.1281897,-0.027083477,-0.084260195,0.039518524,0.016809406,0.0056916825,0.108730465,0.0048187133,0.034186404,-0.024268633,0.012984854,-0.0805814,-0.037007924,0.08475127,-0.08061672,-0.01019935,0.022682564,0.029711366,-0.014940877,-0.051692426,-0.040535383,0.045649376,-0.06464226,0.017967826,0.006319145,0.06477309,-0.008136855,-0.00039652415,0.033199035,0.00062478246,0.023981296,-0.035819262,-0.07763324,0.04294304,0.025956243,-0.04494991,0.017265758,-0.004301436,-0.028855393,-0.021585893,0.20202106,0.013040379 +5.5.1.36,"Requires Ca2+. The enzyme, which belongs to the Stig cyclases, has been characterized from multiple species of the cyanobacterial genera Fischerella and Westiellopsis. Stig cyclases catalyse a three step process including a Cope rearrangement, 6-exo-trig cyclization and electrophilic aromatic substitution. The enzyme is a heterodimer of two different proteins (AmbU1 and AmbU4). On their own, AmbU1 catalyses a different reaction, producing 12-epi-hapalindole U (cf. EC 5.5.1.32, 12-epi-hapalindole U synthase) while AmbU4 appears to be inactive. Formation of hapalindole U leads to the biosynthesis of additional terpenoid indole alkaloids such as hapalindole G, ambiguine H, and ambiguine A.",384,0.99999994,-0.009389304,0.003344378,-0.075592205,0.027818935,-0.0114637725,0.09690575,-0.08760262,-0.002204582,0.0780812,-0.033978365,-0.0013865867,-0.046075583,-0.024308847,-0.03078872,-0.088177346,0.061732996,-0.069424964,0.0451525,0.020488728,-0.0697606,0.07990157,0.039075725,-0.0037873618,-0.009719231,0.034951616,-0.041368093,-0.016150218,-0.004872576,0.027132977,-0.050975956,-0.0014067015,-0.032285206,0.043659378,-0.08088262,0.03663701,0.07486925,-0.0951556,-0.08420783,0.034790102,-0.027596932,0.044329215,0.01463261,0.02669021,0.049613155,-0.027564587,0.0061209276,0.057133976,0.03164675,0.045878593,-0.041026596,-0.010386171,-0.008734206,-0.028744806,0.031649105,0.03024876,0.00865527,-0.09698955,0.033247154,0.0728774,0.023893772,0.0340618,0.058834847,0.060624518,-0.018827042,-0.06366338,-0.022985041,-0.095972665,0.012577026,0.015273397,-0.00661702,-0.053917337,-0.066911265,-0.09590538,0.010106987,-0.057770822,0.08928214,-0.016916659,0.013034953,-0.03624784,0.0038115836,0.03933474,0.008286462,0.08924895,-0.03613535,0.052033268,0.022059888,0.031630356,0.010294219,0.009856201,0.023266805,0.13605766,-0.022215119,-0.020333167,-0.055840686,0.020155728,0.04714633,0.054054033,0.057469577,0.013361362,-0.0032666856,0.061977286,-0.019715197,-0.02576616,-0.05593934,-0.032274,0.019138472,0.026476154,0.004119924,0.050297245,-0.012495062,-0.041439455,-0.06463598,-0.019188903,-0.05807251,0.020907858,0.0651364,0.0052852603,-0.020863947,0.02067071,-0.017779743,-0.0142031945,0.02800491,0.05885046,0.02605263,0.04327811,-0.009721174,-0.14390457,5.8946244e-33,0.089111716,0.07778585,0.015184008,0.019508464,0.019446656,-0.08471121,-0.044392187,0.003134243,-0.0874566,-0.030094326,-0.045761198,0.048661143,0.00644437,-0.065556906,-0.005441795,-0.012516577,0.012110348,0.005708449,0.08902609,-0.06141761,-0.09296908,-0.020291187,-0.04706913,-0.004522675,-0.061511584,0.049132276,0.01308505,0.012440718,0.06136077,-0.015794609,-0.058431666,-0.055482086,-0.12511931,0.0016393885,0.009056851,-0.06156203,-0.061296593,-0.0042168414,-0.019471621,0.024688613,-0.024322549,0.08212232,-0.04732665,-0.040307466,0.13893774,-0.030842485,-0.07539795,0.049434137,0.04421959,0.019622156,0.020037802,0.012413993,0.123489544,0.0029588258,-0.091147214,-0.001528088,0.017033352,0.060042284,0.015224772,0.05508579,-0.08108976,0.014280747,-0.06587043,0.01211954,0.0024868743,0.09246652,-0.085279256,-0.01234947,-0.04506111,0.1048501,-0.03143349,-0.07612124,0.08042368,0.02545494,0.050612036,0.020596921,-0.038860876,0.016980952,0.03613783,-0.014435061,-0.067081176,0.031165197,-0.00837411,-0.02721663,0.0046532727,-0.055896673,-0.04538625,-0.048243098,0.021604013,0.13891475,0.058321122,-0.09269895,-0.036009744,0.10414338,-0.029721411,-6.551063e-33,0.07883055,-0.050820593,0.040676374,-0.0946263,-0.014978421,0.048578564,0.02812829,-0.007055918,0.010247856,-0.06429705,0.05951775,-0.045874007,0.09607466,0.06470171,-0.039736785,-0.042017136,0.04908017,0.15822953,-0.040265173,-0.0037584386,0.025175754,0.0385328,0.023540435,0.0062105125,-0.012528775,0.044053953,0.0550291,0.03372416,-0.0009943258,0.04414722,0.031929757,-0.050219685,-0.083573245,0.017998211,-0.08622662,0.043349493,-0.03860497,0.005773097,0.054191407,0.08023679,0.049306765,0.0070258398,0.027102888,0.05287522,0.08779844,0.037456576,-0.10266016,0.0701704,-0.04526832,-0.06425601,0.013726059,0.011646696,-0.049678694,-0.03780696,-0.03503931,0.02101362,0.088422455,-0.005337826,-0.0015586528,0.011553352,-0.028294979,-0.04504755,0.043620706,-0.034482747,0.0060109827,0.034624286,0.04466647,0.042516083,0.020590287,-0.03655913,0.04974068,-0.019110901,-0.014066653,-0.013294649,0.038756788,0.04123518,-0.011141573,-0.13966471,0.0013984059,-0.05990954,-0.032579184,-0.027965074,0.027407188,-0.06269279,-0.034919493,-0.036356088,0.09189018,0.07556396,0.047234118,0.06007226,0.029217273,0.06636603,-0.026817707,0.09386242,0.049009718,-4.853852e-08,0.03233922,-0.04706466,0.006906337,-0.043247372,0.00072024675,0.064231776,-0.054848872,-0.020053038,0.015760006,-0.058205795,-0.025767097,0.008283904,-0.015999382,-0.019334108,0.07082255,-0.0097751245,-0.06442878,-0.06379131,0.0046602734,-0.042050306,-0.057129383,0.0335134,-0.070872515,0.010676275,-0.0010994717,-0.14235917,0.045878038,0.017900908,-0.015285912,-0.00593865,0.030086866,0.06830589,-0.036510397,0.024121514,-0.041113175,-0.036909863,-0.039042644,-0.044224508,-0.016816825,0.012978646,-0.012050287,-0.022137664,-0.07468722,0.005438889,-0.051596735,0.01052294,0.0002837132,0.05870247,-0.019132324,-0.036142033,-0.009798304,-0.0437391,-0.026483912,-0.0570575,-0.027942834,-0.027238064,-0.017356494,0.022186078,-0.0061207144,-0.12700282,-0.0014091892,-0.07008364,0.14513019,-0.0047191232 +5.6.2.5,"RNA helicases, which participate in nearly all aspects of RNA metabolism, utilize the energy from ATP hydrolysis to unwind RNA. The engine core of helicases is usually made of a pair of RecA-like domains that form an NTP binding cleft at their interface. Changes in the chemical state of the NTP binding cleft (binding of the NTP or its hydrolysis products) alter the relative positions of the RecA-like domains and nucleic acid-binding domains, creating structural motions that disrupt the pairing of the nucleic acid, causing separation and unwinding. Most RNA helicases utilize a mechanism known as canonical duplex unwinding, in which the helicase binds to a single stranded region adjacent to the duplex and then translocates along the bound strand with defined directionality, displacing the complementary strand. Most of these helicases proceed 3' to 5' (type A polarity - cf. EC 5.6.2.6, RNA 3'-5' helicase), but some proceed 5' to 3' (type B polarity), and some are able to catalyse unwinding in either direction [1,4]. Most canonically operating helicases require substrates with single stranded regions in a defined orientation (polarity) with respect to the duplex. A different class of RNA helicases, EC 5.6.2.7, DEAD-box RNA helicase, use a different mechanism and unwind short stretches of RNA with no translocation.",384,0.99999994,-0.010575247,-0.10945204,0.00033606758,-0.04436924,-0.05442695,0.0648797,-0.061282523,-0.01943752,0.019424362,0.022451008,-0.053785898,0.09748135,-0.0248467,0.022085018,0.0054358332,0.06256725,-0.09533478,0.02450801,-0.050768293,-0.009959568,0.106853716,0.024553776,-0.039077654,-0.036387213,-0.016017227,0.090830326,0.056754284,-0.02834696,0.06644294,-0.11496205,-0.010894236,-0.030192288,-0.07638622,-0.009363724,0.04493628,0.053884167,-0.0079273265,0.030916397,0.002927541,0.038113154,0.06825474,0.05600721,-0.013544796,-0.013412166,-0.045105923,-0.03174491,-0.0034055084,0.054883968,0.015264642,-0.030660152,0.016550539,-0.02157639,-0.0026866836,-0.0014199074,-0.0077461596,0.11038417,-0.003899665,0.027479382,-0.0033414804,-0.023376642,0.028191993,-0.040041234,-0.03481689,-0.0064860675,0.14784345,-0.05649096,0.06617974,0.050628487,-0.020743197,0.030970154,0.0020532461,-0.006208127,-0.063637905,0.06995322,0.0445615,0.005686932,0.0032276667,-0.029105274,-0.006333899,0.060218006,-0.07043886,0.039156187,0.054643173,0.061663214,0.034139324,0.055209793,-0.0033808607,0.02700326,0.01689595,0.03188149,-0.09428336,-0.07570077,0.044007704,-0.02248949,0.06663545,0.0327714,0.039976392,0.02471473,0.01635957,-0.06408197,0.0964743,0.05660795,-0.034733377,0.036792055,-0.008789734,0.042011466,-0.04102148,0.06836678,0.02087849,0.0068731452,0.012167498,0.0038476256,0.06637257,-0.04699165,-0.022288283,0.03068567,-0.05075951,0.030717425,0.08013356,0.014461415,-0.0036433213,-0.07734329,-0.01805779,0.07282421,-0.019873898,-0.057357013,-0.07580062,1.7430697e-33,-0.026232852,-0.027913142,-0.013483194,0.007460358,0.0075284922,-0.01932737,-0.12638335,-0.01745059,-0.062195495,0.04740778,-0.03676248,0.094639935,0.0330863,-0.017549345,-0.08818759,-0.08967748,0.03127555,0.09248043,-0.067815304,-0.011354103,-0.0059837773,0.07004693,0.0037249988,0.014368537,-0.025830656,-0.031096896,-0.05090839,-0.037689798,0.03877116,-0.0047386726,-0.040112983,0.024054045,-0.0829038,0.07020243,0.06729137,-0.008520811,-0.015769416,-0.026092015,0.024973175,0.07366713,-0.005883339,-0.019465016,-0.03878442,-0.01686398,0.045087874,-0.12750277,0.010673311,0.017221317,-0.09597336,-0.05260788,0.11192662,-0.0056692595,0.08756718,-0.0798499,0.010569313,-0.077992536,0.018354679,-0.0042811027,0.028659439,0.09031156,-0.0004177428,0.0110399965,-0.02884097,0.03919475,0.008134987,0.01663641,-0.047595512,-0.04232089,0.07057071,0.09533636,-0.07328327,0.08811135,0.06528336,-0.014082218,-0.006877411,-0.0047275377,-0.03157813,0.020743633,0.05195725,0.10551496,0.007653342,-0.046016544,-0.054096658,-0.0825491,-0.1013522,-0.068738066,-0.03652682,-0.1173087,-0.05184533,0.023586702,0.070596464,-0.015979867,0.064239815,-0.006798542,0.06368024,-3.8561075e-33,0.02953035,-0.06602898,0.0024220347,-0.035161596,-0.062469028,0.029631587,0.018325474,-0.032216337,-0.028894352,-0.12708865,0.039596867,0.0010518946,0.022419836,-0.01648951,0.0095510855,0.03722651,0.054655403,0.025549844,-0.007474212,-0.040601093,0.017584257,0.06360808,-0.025676971,0.06987287,0.03603481,0.0026557853,-0.07257481,0.0070453426,0.0893979,0.02946321,0.02225835,-0.038974307,-0.020533662,-0.011166544,-0.073195234,0.07088767,-0.08641168,0.0058664144,0.046133038,-0.013083082,0.0148933,0.05918516,0.006751313,0.029114606,0.033621605,0.076531835,-0.07770872,0.081367075,0.009025798,-0.03591361,0.05179796,0.022893265,-0.022524176,0.05705187,0.026871907,-0.0017330648,-0.03727915,0.0028957825,0.07925371,0.029141176,-0.026372142,-0.082217656,-0.022746297,-0.0361547,-0.05792927,-0.01074756,0.009291265,-0.010419504,-0.027628485,-0.015572834,-0.028230796,-0.0040176343,0.04674061,-0.037667286,0.040530566,0.01097046,0.014148078,-0.11926775,-0.08291775,-0.014892748,-0.13774988,0.04466941,-0.057276126,-0.08707571,0.054284163,-0.021647198,-0.012504329,0.031033175,0.03178697,0.024781961,0.06842925,-0.0028198883,0.009766341,0.06146309,0.015643302,-4.5929575e-08,0.065961555,-0.037675723,0.049070936,-0.018772231,0.014399947,-0.0021752631,0.024521764,0.06269302,0.09666147,-0.071211964,0.018229548,-0.023773916,-0.037693497,-0.048571113,0.12902872,0.019779991,-0.029432552,-0.0499546,0.003862516,-0.10803443,-0.063082784,-0.048100926,-0.030534515,0.07557802,-0.12131549,-0.03850694,0.007693206,0.020453302,0.042877316,-0.027875694,-0.03612281,0.07027923,0.018531365,-0.050940264,-0.11284505,0.047714643,0.074791096,0.04313006,-0.031271875,0.004072085,0.08116805,-0.006818451,-0.0577999,0.018876674,-0.057453368,0.019894859,0.031247899,0.05541884,-0.010946637,-0.044790115,-0.052618068,0.04151014,0.02378314,-0.034853205,-0.014218252,0.032017153,-0.047766536,-0.060530037,-0.019391622,-0.00053149526,-0.06713146,-0.001914181,0.07470012,-0.08890613 +5.6.2.6,"RNA helicases, which participate in nearly all aspects of RNA metabolism, utilize the energy from ATP hydrolysis to unwind RNA. The engine core of helicases is usually made of a pair of RecA-like domains that form an NTP binding cleft at their interface. Changes in the chemical state of the NTP binding cleft (binding of the NTP or its hydrolysis products) alter the relative positions of the RecA-like domains and nucleic acid-binding domains, creating structural motions that disrupt the pairing of the nucleic acid, causing separation and unwinding. Most RNA helicases utilize a mechanism known as canonical duplex unwinding, in which the helicase binds to a single stranded region adjacent to the duplex and then translocates along the bound strand with defined directionality, displacing the complementary strand. Most of these helicases proceed 3' to 5' (type A polarity), but some proceed 5' to 3' (type B polarity - cf. EC 5.6.2.5, RNA 5'-3' helicase), and some are able to catalyse unwinding in either direction [1,3]. Most canonically operating helicases require substrates with single stranded regions in a defined orientation (polarity) with respect to the duplex. A different class of RNA helicases, EC 5.6.2.7, DEAD-box RNA helicase, use a different mechanism and unwind short stretches of RNA with no translocation.",384,1.0,-0.012970574,-0.11057385,0.0002533045,-0.042708635,-0.052432813,0.065282814,-0.058932077,-0.022706738,0.019383585,0.02372857,-0.054977,0.097510315,-0.02617215,0.022579977,0.0062510874,0.06532259,-0.09677859,0.025526833,-0.053375255,-0.009476877,0.106590375,0.022459695,-0.0421062,-0.03281079,-0.014063907,0.09071904,0.057833545,-0.028520502,0.06586789,-0.11473499,-0.009486482,-0.030609658,-0.07718031,-0.0087967515,0.042844918,0.052735154,-0.009299643,0.031062577,0.0014109532,0.03741372,0.068125,0.053335264,-0.015938254,-0.01466164,-0.044363778,-0.028937155,-0.0044273995,0.05574449,0.015830172,-0.032631524,0.012407343,-0.02297674,-0.006820914,-0.0013641075,-0.008060984,0.11038681,-0.0018887316,0.027633008,-0.0027757385,-0.026704513,0.031344987,-0.038071822,-0.036708526,-0.008146997,0.14856954,-0.05681992,0.06349092,0.05144638,-0.018394072,0.033533916,0.002243576,-0.005401987,-0.06372677,0.0693897,0.046463873,0.005102469,0.004927918,-0.02856694,-0.0076055047,0.05848692,-0.070151575,0.038855735,0.052958425,0.064154334,0.033883218,0.056350693,-0.004924196,0.027304662,0.017070418,0.029556416,-0.093354434,-0.073840015,0.043899216,-0.02201528,0.066476576,0.029172555,0.04240184,0.02381252,0.016971612,-0.06256255,0.09519843,0.055589326,-0.035037868,0.0352317,-0.009369252,0.041454,-0.042816404,0.06564307,0.023431132,0.0059495447,0.012194154,0.002193751,0.066577,-0.04634502,-0.023846665,0.029974543,-0.051550597,0.030047962,0.07939914,0.012038358,-0.0013661959,-0.07553072,-0.022982048,0.07184943,-0.021065205,-0.05776874,-0.07401353,1.9627855e-33,-0.026854288,-0.030090595,-0.012693802,0.010837446,0.009035406,-0.016185084,-0.12762871,-0.018336788,-0.060374144,0.04666079,-0.038808312,0.093049064,0.034445327,-0.017888611,-0.08560044,-0.09012347,0.028071523,0.09315217,-0.06741811,-0.011560904,-0.004748127,0.074115984,-0.00083396526,0.009565704,-0.028804738,-0.03319536,-0.04980177,-0.038280047,0.036466718,-0.005223052,-0.040900197,0.026602687,-0.08306348,0.07272451,0.06915145,-0.007468447,-0.014245783,-0.026893295,0.024980642,0.07509179,-0.0063762316,-0.02146506,-0.042161316,-0.016939588,0.04686765,-0.12571765,0.009820228,0.019068815,-0.09946438,-0.049731493,0.10956343,-0.004415297,0.088566944,-0.07933053,0.010825473,-0.07641735,0.019568088,-0.0035469267,0.028563963,0.09292652,0.00018312046,0.01301193,-0.026596563,0.037953414,0.008652955,0.014491581,-0.04526409,-0.043649346,0.07564845,0.09600194,-0.073152974,0.08998671,0.068497516,-0.015350607,-0.011067127,-0.0032690973,-0.03442041,0.022651091,0.053642355,0.10382653,0.0042968513,-0.048925165,-0.051207658,-0.08034992,-0.10521519,-0.067694955,-0.03528726,-0.119518265,-0.05383282,0.022301218,0.0705015,-0.016444938,0.0626139,-0.008752394,0.06338752,-3.980322e-33,0.029745253,-0.06941676,0.0026118115,-0.034882862,-0.06349012,0.03007654,0.017232612,-0.035132665,-0.02817137,-0.123827025,0.039405495,0.0010051782,0.022938455,-0.015918924,0.009419682,0.03837382,0.05672956,0.026525885,-0.0057033845,-0.040281355,0.019739833,0.06711339,-0.028071333,0.070197694,0.036680702,0.004836201,-0.06975881,0.007418152,0.09037052,0.0317497,0.021079179,-0.03973764,-0.02121984,-0.016186073,-0.069668226,0.07323205,-0.08588362,0.0052761673,0.044188704,-0.01591021,0.014610199,0.057930026,0.0094836,0.028897326,0.034622684,0.07552381,-0.078063406,0.08270182,0.008272802,-0.03650404,0.053460713,0.02239299,-0.021614963,0.053778674,0.025207654,-0.002681953,-0.03581255,0.00077692367,0.081410535,0.02898719,-0.03047217,-0.084208846,-0.02127861,-0.034775425,-0.053302474,-0.0073670275,0.012989902,-0.012072607,-0.023054762,-0.019358745,-0.026279975,-0.0010911534,0.048242923,-0.039482653,0.039517187,0.008606685,0.017239574,-0.11782472,-0.08524111,-0.013741554,-0.13724864,0.042006005,-0.05431655,-0.08690614,0.0525098,-0.022563674,-0.015116027,0.03185184,0.034566995,0.022184316,0.070003204,-0.000386795,0.009573026,0.06295685,0.018118806,-4.5731095e-08,0.06677143,-0.040673837,0.045628287,-0.01795984,0.014204651,-0.002987726,0.024584243,0.064160384,0.095072985,-0.06959593,0.016319072,-0.024334516,-0.03670497,-0.04674538,0.12921765,0.020977134,-0.030429749,-0.051295653,0.0030154057,-0.108270355,-0.06249314,-0.04673712,-0.030989008,0.0768735,-0.11817379,-0.03691805,0.007036066,0.019847112,0.045934133,-0.025952166,-0.034390546,0.07168483,0.01635754,-0.04867793,-0.11160044,0.04824152,0.07341671,0.044867974,-0.033267844,0.0043367725,0.07623496,-0.007016587,-0.061040744,0.019079365,-0.053440463,0.016332634,0.030460702,0.054024927,-0.007906533,-0.043345902,-0.051557392,0.044570122,0.02642995,-0.034103356,-0.015492426,0.03190592,-0.047644496,-0.059862573,-0.019507693,0.0027971042,-0.06597376,-0.00027874665,0.07466631,-0.08732292 +5.6.2.7,"RNA helicases, which participate in nearly all aspects of RNA metabolism, utilize the energy from ATP hydrolysis to unwind RNA. The engine core of helicases is usually made of a pair of RecA-like domains that form an NTP binding cleft at their interface. Changes in the chemical state of the NTP binding cleft (binding of the NTP or its hydrolysis products) alter the relative positions of the RecA-like domains and nucleic acid-binding domains, creating structural motions that disrupt the pairing of the nucleic acid, causing separation and unwinding. While most RNA helicases utilize a mechanism known as canonical duplex unwinding and translocate along the RNA (cf. EC 5.6.2.5, RNA 5'-3' helicase and EC 5.6.2.6, RNA 3'-5' helicase), DEAD-box RNA helicases differ by unwinding RNA via the local strand separation mechanism, which does not involve translocation. These helicases load directly on the duplex region, aided by single stranded or structured nucleic acid regions. Upon loading, the DEAD-box protein locally opens the duplex strands. This step requires binding of ATP, which is not hydrolysed. The local helix opening causes the remaining basepairs to dissociate without further action from the enzyme. Unwinding occurs without apparent polarity, and is limited to relatively short distances. ATP hydrolysis is required for release of the DEAD-box protein from the RNA. The name originates from the sequence D-E-A-D, which is found in Motif II of these proteins.",384,1.0,-0.011470711,-0.08500985,-0.008781449,-0.03672886,-0.021352803,0.033529762,-0.06460806,-0.023523651,0.021967532,0.011069702,-0.06473003,0.08658795,-0.044189412,-0.0020559675,-0.006440195,0.05010065,-0.06865704,0.029529478,-0.054915603,-0.023275346,0.12265223,0.04282809,-0.039123576,-0.047259256,0.014344188,0.08395626,0.04556537,-0.024790185,0.04745201,-0.103170104,-0.03777747,-0.046906993,-0.0637446,-0.034688435,0.042490274,0.085968904,-0.0231653,0.0011620848,0.0093537215,0.042077195,0.042126287,0.050092854,-0.0052072466,0.004144346,-0.04526819,-0.032187272,-0.025518762,0.062909275,0.015046841,-0.01647282,0.021918254,-0.03528541,0.006528537,0.012127717,-0.014936407,0.12359866,0.019270433,0.028127115,-0.035260525,-0.028910544,-0.0002472229,-0.0333585,-0.013801718,-0.0036469721,0.15339673,-0.06078401,0.07840409,0.027339006,-0.002524068,0.01742124,-0.027180484,-0.0041910787,-0.0462586,0.09861985,0.015460714,-0.013582553,-0.013719474,-0.053741224,-0.0038927516,0.042821355,-0.05831405,0.038293626,0.059095934,0.04058291,0.01262851,0.05862112,-0.006748687,0.038451515,-0.0028551372,0.03888804,-0.073140614,-0.038950454,0.062260766,0.006966967,0.067340784,0.043578394,0.035081584,0.059704363,0.018212736,-0.073061615,0.086509086,0.060631752,-0.03489952,0.042786736,0.0074662664,0.05037104,-0.068754494,0.10311724,0.0037360147,0.040444005,0.014815125,-0.004122325,0.05171027,-0.050714742,-0.025541695,0.04707568,-0.044088587,0.011706597,0.070726655,-0.019464236,0.00661034,-0.0915914,-0.002487126,0.060561832,0.0009479296,-0.05538575,-0.05937043,1.3232413e-33,-0.04244948,-0.08193532,-0.015642608,0.032708608,-0.0020245435,-0.027814755,-0.12532163,0.00096320297,-0.034243964,0.061560206,-0.031350765,0.069256775,0.035405498,-0.046649884,-0.10028553,-0.08398831,0.026916785,0.08444573,-0.06011538,-0.015096536,0.00952621,0.084515125,-0.0002312854,0.01913778,-0.025662998,-0.0010399764,-0.04273239,-0.046825536,0.00910059,-0.007166257,-0.037443683,-0.0034398157,-0.070630684,0.033151593,0.044083912,-0.009839535,0.004380199,-0.035366014,0.014797344,0.089520976,0.02790772,-0.02511529,-0.009566722,-0.036124993,0.035059005,-0.13836487,0.021599503,0.043033976,-0.098703004,-0.05488482,0.11424493,-0.027481943,0.074015036,-0.0665312,-0.0051398785,-0.06172679,-0.00080955797,-0.010048753,0.04564705,0.0820437,0.0014134409,0.013307947,-0.015783682,0.079541065,0.028289521,0.02115371,-0.06566853,-0.051534086,0.052292705,0.09886249,-0.047793247,0.07595856,0.08697455,-0.0031566771,0.0031281684,-0.0076226466,-0.043370467,0.019558184,0.010640826,0.108388044,0.03997502,-0.048984706,-0.070201166,-0.08450333,-0.09385169,-0.052446105,-0.016350258,-0.11982599,-0.037673805,0.030129256,0.072015375,-0.04093352,0.028601333,-0.006245223,0.071850635,-2.907263e-33,0.04097713,-0.04355324,0.0058192722,-0.013180093,-0.038453083,0.02269089,0.010156626,-0.038936943,-0.010374202,-0.10783128,0.023965906,-0.0024627545,-0.014609067,-0.019455334,0.042760156,0.029164245,0.030586457,0.02147081,-0.03530441,-0.023158949,0.026467526,0.07121983,-0.047254067,0.07579977,0.031472985,-0.0075412137,-0.09499374,0.015313996,0.090823844,0.03611819,0.042498015,-0.03416809,-0.028654741,0.005875096,-0.07348012,0.0644502,-0.068074234,0.013033384,0.05139456,-0.024937399,0.024393478,0.07386157,-0.035237532,0.020224145,0.036141843,0.08012781,-0.08935352,0.060983058,0.016305672,-0.023858864,0.060099322,0.007059578,-0.032186866,0.06335678,0.012000731,0.033069003,-0.05371709,0.027891811,0.08177599,0.026696384,-0.004756914,-0.09588019,-1.9687737e-05,-0.037016574,-0.044927396,-0.019817783,0.016793108,0.043134883,-0.029488713,-0.022222182,-0.022529526,-0.014429727,0.059874617,-0.03241482,0.048396718,0.0024326486,-0.003969839,-0.079903245,-0.06372589,-0.0050663957,-0.13794032,0.02968236,-0.06584624,-0.051782563,0.07500134,-0.0006794431,-0.031615004,0.03845193,0.020032117,0.023202628,0.031849843,-0.012419203,0.012786814,0.06093783,-0.0046372586,-4.2808676e-08,0.082164645,-0.02951145,0.0536536,-0.025349036,0.00904156,0.026380284,0.015409659,0.08996511,0.09532956,-0.057128172,0.0305218,-0.02021485,-0.058213145,-0.05995528,0.09954491,0.027470458,-0.06420863,-0.040036593,0.0024072027,-0.10593035,-0.05909508,-0.030906968,-0.022966055,0.07467532,-0.12407386,-0.029444762,0.03932564,0.029812232,0.05679595,-0.027554428,-0.052182432,0.08553745,0.05589129,-0.04094915,-0.10006818,0.03974711,0.10021523,0.052879892,-0.05980383,0.037516847,0.059870504,-0.04816541,-0.06898383,-0.0035481043,-0.042298727,-0.0075263684,0.011520969,0.05984493,-0.023715418,-0.041760035,-0.030120285,0.048335873,-0.0057003074,-0.01769947,0.013220055,0.0111901015,-0.035997022,-0.054012474,0.013873789,0.014670415,-0.07232178,-0.0149498535,0.10597171,-0.09753715 +6.3.2.63,"Requires Mg2+. The enzyme, characterized from the bacteria Shewanella spp. MR-4 and MR-7, catalyse the last step in the biosynthesis of the siderophore putrebactin. The enzyme catalyses the reaction in two steps - concatenation of two molecules of N1-hydroxy-N1-succinylputrescine, followed by cyclization.",384,1.0,-0.082707584,-0.059742536,-0.051075343,0.0076641953,-0.025073964,0.03636844,-0.027555449,0.03403737,-0.047766056,0.017188441,0.011445408,-0.010357631,0.008471061,0.030922737,-0.036967464,0.028267264,-0.0049847127,0.032077737,0.020759577,-0.043241657,0.06017786,0.020444619,-0.033003908,-0.020688428,0.006427773,0.055770706,0.048593193,0.017660193,0.0077154865,-0.01779503,-0.012923675,-0.03476386,-0.013898164,-0.14485969,0.06028397,0.10989546,-0.041586477,-0.02982237,0.062489547,-0.057962533,0.012974574,-0.03424982,0.09853771,-0.03175104,-0.04288323,-0.043472722,0.13027619,0.021795709,0.08578417,-0.0633122,-0.04376092,-0.0028900646,-0.07495206,-0.014491928,0.0380976,-0.030752447,-0.1296857,-0.00031770795,0.023484994,-0.023091963,0.015321657,0.0017156138,-0.012257587,0.004664811,0.038021926,-0.07079515,-0.0043322355,-0.0695012,-0.012282771,0.04808289,0.024959216,-0.006449687,-0.014198013,0.011828637,-0.015314454,0.072416894,0.071862146,-0.0067596883,0.0333616,-0.03265811,0.022892972,-0.028741352,0.040018916,0.12639515,-0.011319995,-0.054705903,0.056874283,0.084138505,0.04939381,0.06668481,0.048654903,0.0117433285,-0.013545739,-0.06308822,-0.07184479,0.015652461,-0.1244461,0.027262567,0.03701559,-0.015183594,-0.019680083,0.070071906,0.025715744,-0.025453659,-0.0067124367,-0.008019625,-0.0092664035,0.06616856,0.107119694,0.05214749,0.044433624,0.01859837,-0.021110347,0.010554132,-0.04800581,0.046291903,0.028175106,-0.100068875,-0.06536412,-0.078372486,0.019307425,-0.035117686,0.02040956,0.067472495,-0.042286422,0.013913011,-0.13397162,3.0353654e-33,0.015776245,-0.0030180707,0.106108546,-0.032105308,-0.02700831,0.024178028,-0.069816016,0.02075762,0.010016208,-0.00937527,-0.08396359,-0.11361375,0.002117971,0.016473455,-0.035671383,-0.110497676,-0.007945191,-0.0155697465,0.041610334,0.028565396,-0.002477666,0.12100259,-0.03849609,-0.010474378,0.0428113,0.08606259,0.07555247,-0.055165067,0.057080217,-0.0055219876,0.047871917,-0.11454155,-0.09664264,-0.021338964,0.028070053,-0.037332766,-0.025556039,-0.043731295,0.052922368,0.0380416,-0.016121395,0.025111262,-0.06713012,0.0013817715,0.08955618,-0.04608607,0.015382588,0.0828931,0.038579326,0.07709208,0.053212434,-0.018252918,0.033700578,0.004149839,-0.094213314,0.05977247,-0.026972273,0.0809244,0.08863119,0.03501918,0.0679302,0.030871503,0.00081530795,0.017827852,0.0803823,-0.011926954,0.026086349,-0.07588558,-0.01791843,-0.00020068302,-0.04849872,-0.027568623,0.057672806,-0.0037712324,-0.014679652,-0.031771354,-0.044281725,0.016659198,0.0945887,-0.036584627,-0.005104958,0.007453469,-0.027331535,-0.032017,-0.02729686,0.015997177,-0.069826216,-0.07175964,-0.039461143,0.0397627,0.02682329,-0.06469238,-0.023050608,0.08527958,-0.043168414,-4.5468107e-33,-0.0098484745,-0.08523665,0.07751144,-0.036499824,-0.07914528,0.0021846672,0.024670918,-0.018794063,-0.016000036,-0.017204568,0.059756298,-0.033364605,0.023633286,-0.059575375,-0.0072113904,-0.02892742,-0.03393356,0.067100614,-0.017178489,-0.014421451,-0.033409595,0.08226103,0.027108919,0.04830621,0.0069321296,0.051934592,0.0690783,0.052194662,0.046851814,0.0945871,0.02145385,0.028126616,-0.05969542,-0.072175235,-0.07535757,0.031571936,-0.019449394,0.0026832896,0.088608384,0.0395558,0.047242824,0.03563573,0.016554238,0.073965676,-0.025554923,0.0332214,-0.089096695,0.09060233,0.048987396,-0.08681484,-0.04059502,-0.0010333695,-0.050475866,-0.051288236,0.029844578,0.003344562,0.06062034,-0.036843866,0.041045364,-0.030409208,-0.034789596,-0.079129964,0.09850767,-0.0077718045,0.018695751,0.13941534,-0.0056097163,-0.03498294,0.0031898248,0.00073216937,0.017153053,-0.01721315,0.010656797,0.013472888,0.025971027,0.07812249,-0.030524483,-0.100972116,0.034675695,-0.016335322,-0.0036330866,-0.028730124,-0.05030143,-0.057840284,0.003774471,-0.14282896,0.063721344,0.077399455,0.00226117,-0.0025879915,-0.029125025,0.0027965705,0.040467717,0.065011725,-0.008972681,-4.0763435e-08,0.011705156,-0.12503414,0.10355896,-0.047866557,-0.007246555,0.07324193,-0.074087,-0.062251277,0.07761196,-0.06326851,-0.009898294,-0.024740648,-0.035603616,-0.00860573,0.0038410258,0.043284964,-0.03455659,-0.06099399,-0.056317504,-0.04738133,-0.09383494,-0.08237383,-0.09592997,0.005495968,0.052372053,-0.064539276,-0.011324618,0.07256646,-0.009409108,-0.046486832,5.1612078e-05,0.011208181,-0.015091646,-0.015617881,-0.08272154,0.01684513,-0.019149233,0.011191283,0.024816027,-0.057397697,-0.004240643,0.01930708,0.008840051,0.011158754,-0.010662414,0.031820208,-0.007282937,0.070413746,-0.07144478,-0.007225219,-0.00555141,-0.032266308,0.02985524,-0.06337069,-0.044229157,0.030365333,0.012180198,-0.015820974,0.02207315,0.016795354,-0.022575643,0.040496197,0.0811257,0.020874634 +6.3.2.64,"Requires Mg2+. The enzyme, characterized from the bacterium Aliivibrio salmonicida, catalyses the last step in the biosynthesis of the siderophore bisucaberin. The enzyme catalyses the reaction in two steps - concatenation of two molecules of N1-hydroxy-N1-succinylcadaverine, followed by cyclization.",384,1.0,-0.04047244,-0.048739217,-0.085767105,0.025508074,0.052525625,-0.0122733,-0.015733749,-0.004791576,-0.016516555,-0.025723543,0.04250558,-0.042689975,-0.016565932,-0.0053837285,-0.059552353,-0.005000107,-0.038611993,0.040235363,-0.033478327,-0.06723253,0.03847464,-0.03456563,-0.015336979,0.035660315,-0.006525441,0.029395878,0.06416933,0.0025061388,-0.0029896675,0.008759255,0.028036013,-0.025960313,0.0851049,-0.1052418,0.03363625,0.07673907,-0.027521795,-0.00421113,0.054189168,-0.0028967063,-0.023779927,-0.015926033,0.032355968,-0.035787288,0.018901229,-0.09333504,0.08229887,0.011855014,0.064710714,0.0054982505,-0.053393822,-0.0074131046,-0.067867406,-0.006556525,0.062368616,0.01732582,-0.14041127,0.0036182236,0.0034860813,0.04331271,0.028781483,0.0032808252,-0.047913883,-0.020312428,-0.001840707,-0.060347755,0.011707643,-0.059023555,0.039363433,0.034374326,0.010925933,-0.04397201,-0.047854595,-0.014786186,-0.006919999,0.045155633,0.058755305,-0.023578059,0.03743787,-0.039611083,-0.0030590105,-0.05628618,0.043114625,0.05515893,0.060477294,-0.020693447,0.07783307,0.04138186,0.059295207,0.08606073,0.108009934,0.036079746,0.053801067,-0.053189483,-0.03914168,0.019062417,-0.07513185,0.0038498794,0.034879226,0.014228345,-0.05363739,0.080344304,0.015777491,-0.09536784,-0.00044832085,0.0263851,-0.040038683,0.07856819,0.06056548,-0.0077024954,0.06305583,-0.013169298,0.023231503,0.0599762,0.016009958,0.09455727,0.008723413,-0.082938716,-0.025438374,-0.016879806,0.0019228316,-0.010134645,-0.034926075,0.077541634,-0.052899107,0.058819123,-0.07806597,5.230355e-33,0.06013348,-0.009672525,0.017963989,0.0059269057,-0.04924958,-0.011742715,-0.067618765,0.03337659,-0.03929892,0.0014443852,-0.025292227,-0.04651531,-0.01729983,0.026204143,-0.022773692,-0.093383834,-0.027924806,-0.025911668,0.07511169,0.044311758,-0.04023553,0.07207108,-0.023712277,-0.05146138,0.055534024,0.06858061,0.057466283,-0.0048519955,0.050870672,-0.00827459,0.054368492,-0.13749301,-0.11559487,0.0259645,0.05273205,-0.02239558,0.056620497,-0.035868637,-0.02586598,0.10096895,-0.08990236,0.028449148,-0.00086547877,-0.006929232,0.07854321,-0.032492273,0.034607474,0.07481864,0.09184433,0.080966786,0.034217138,0.03560629,0.08124382,0.008673072,-0.08299343,0.060682688,-0.036026012,0.039817948,0.06190164,0.039644636,-0.026038034,0.024524583,0.0055766394,-0.012789148,0.027932933,0.029697834,-0.061532117,-0.086761095,0.031410445,-0.010776334,-0.0496662,-0.036217857,0.05583856,0.02239737,0.03044769,-0.009699207,-0.05727905,0.011510648,0.03825724,-0.0027029589,-0.046898246,0.04153719,0.01635064,0.026005391,-0.11411619,0.03921043,-0.063878454,-0.07042444,-0.04504628,0.033211686,-0.016933603,-0.011926605,-0.028395927,0.070192285,0.012510393,-5.0431095e-33,0.04907783,-0.102178596,0.026902664,-0.052904386,-0.14222054,0.03785022,0.027593788,-0.08660558,-0.024817012,-0.025595246,0.083105296,-0.037191503,0.055753723,-0.03631294,-0.01802268,-0.03005974,0.050302107,0.056803018,-0.03154848,-0.01814508,0.010945706,0.12545282,0.057534005,0.029942736,0.05927988,0.03846594,0.0707531,0.05987814,0.07346485,0.08366789,-0.014492096,0.03724396,-0.012678059,-0.06908122,-0.07338735,0.07557972,0.0020119257,0.022417193,-0.0022851846,0.06063009,0.014821512,0.016139152,0.0059497855,0.1208795,0.030134674,0.04149391,-0.016701398,0.095804885,0.0075464537,-0.054506086,-0.0038231644,-0.013854816,-0.01818886,-0.052839417,0.09002393,-0.018527903,0.018413166,-0.037563317,0.01967546,-0.023185326,-7.2256826e-06,-0.07080623,0.0868565,-0.09780132,0.020614237,0.1157658,-0.040055297,-0.018463643,0.016115434,-0.03787482,0.07771142,-0.0041613122,0.046180848,0.032573,-0.043109257,0.061941925,-0.018613707,-0.1000373,-0.0004945672,-0.01714706,-0.0010456627,-0.019625124,-0.024139464,-0.06062283,-0.023781182,-0.12921478,0.037281763,0.04515529,-0.0019441568,-0.017896455,-0.055477604,-0.031231932,-0.017872445,0.04220145,0.021140385,-3.911002e-08,-0.011710112,-0.10052032,0.033545922,-0.06647353,-0.011182982,0.076997966,-0.022275139,-0.092345156,0.02684917,-0.08365486,-0.0169287,0.032598224,-0.018321985,0.060002394,-0.01975355,0.054063182,-0.014957643,-0.051391147,-0.029635515,-0.05382566,-0.080756895,-0.083102636,-0.14851995,-0.0042085797,0.017815998,-0.10152605,-0.027275683,0.06025752,0.030547736,-0.035825368,-0.02438865,-0.013141989,0.019745829,0.036222488,0.021124413,0.053423077,-0.08776667,0.005841196,-0.011732025,-0.05821664,-0.03044931,0.0332958,-0.022944026,-0.010272315,-0.02702237,0.0039794883,0.03780637,0.093892135,-0.051818095,0.017766863,0.07454952,-0.11161914,0.055253077,-0.04473478,-0.0616539,0.030466413,0.021294126,-0.06691287,0.010243673,0.04278202,-0.03249918,0.021989457,0.07041854,-0.049873307 +7.2.1.4,"Involved in the formation of methane from CO2 in methanogenic archaea. The reaction involves the export of one or two sodium ions. The enzyme from the archaeon Methanobacterium thermoautotrophicum is a membrane-associated multienzyme complex composed of eight different subunits, and contains a 5'-hydroxybenzimidazolyl-cobamide cofactor, to which the methyl group is attached during the transfer. A soluble enzyme that is induced by the presence of CO has been reported as well [6].",384,1.0,-0.018641578,-0.038407292,-0.13061759,-0.01768048,0.04900127,-0.025387146,-0.049395554,-0.00010144518,0.025601862,-0.027516363,-0.017322676,-0.16148183,-0.04651349,-0.010110662,-0.038382735,-0.020282203,-0.05466049,-0.063866004,0.005208663,-0.0184266,0.10161968,0.08708136,-0.04938687,-0.026060946,-0.031538032,0.028983042,0.026091615,-0.06473837,-0.00045806429,-0.0024592034,-0.0087265195,-0.02148497,0.04400098,0.0043610004,0.067995004,0.0980546,-0.0023579653,-0.053651474,0.07179845,0.022703797,0.046168897,0.02651216,0.12498952,-0.039166763,-0.047555994,0.029536445,0.03971785,-0.025786558,0.050012015,-0.07488191,-0.03583065,-0.0690808,-0.0961627,0.039560508,0.0013141392,0.12740612,-0.017728971,-0.04482082,0.031489756,-0.063452154,0.07971696,0.025005238,0.07163647,0.02250736,0.011777391,-0.04098743,0.05251497,-0.074905105,0.067001715,-0.051804043,-0.044671316,0.0041815117,-0.02319215,-0.06996995,-0.064942464,-0.010587232,-0.014211534,-0.04489371,0.08270943,-0.051621083,0.008484309,-0.004085454,0.014090371,-0.039615512,0.0006914929,-0.0031420856,0.06890412,-0.017252741,0.07583928,-0.027885923,-0.03086565,-0.018566905,0.061251733,-0.020873977,-0.11801361,-0.030862516,0.12572198,0.08838365,0.003123824,-0.040130284,0.029617187,0.06468949,-0.02213069,-0.08491653,-0.08208653,-0.044207722,0.07261801,0.12762637,0.03709804,0.08472346,-0.026036672,0.022837026,0.060692787,-0.0040152697,0.057310596,0.06497307,0.0572202,-0.059525218,-0.064508274,0.056414373,-0.012111101,-0.06920684,0.09732659,-0.005570319,-0.03848134,0.046032686,-0.076500624,2.8254199e-33,0.051105656,-0.010970147,-0.045064554,-0.017869877,0.035961147,-0.03606971,-0.08553851,-0.037194002,-0.009639733,-0.032107998,-0.061734483,0.011324761,0.03180294,0.033417895,-0.09361077,0.025852993,-0.054464307,-0.04953933,0.01690297,0.052132133,-0.051171035,0.08667345,0.014800082,0.046306223,0.030059405,-0.032084346,0.006734506,-0.036979273,0.028547691,0.007544828,0.0042130565,-0.11777058,-0.15193841,0.020335626,0.08213772,0.054736298,-0.04321916,-0.011503648,-0.07573048,-0.0023937484,-0.010464908,-0.0075695575,0.0071414374,-0.027242923,0.051573567,0.00106868,-0.05368155,0.14202234,0.025582453,-0.022210654,-0.0690334,-0.007173028,0.051714096,-0.02916904,-0.09399835,-0.02624333,0.03422063,0.009876246,0.039673857,0.047194052,-0.02180903,0.05938622,-0.0042153625,0.13075016,-0.007881465,0.04230531,-0.028342078,-0.023625357,0.10773348,0.03492851,-0.053637862,-0.035044767,-0.0022923846,0.08690225,0.009163223,-0.067342,0.015874228,-0.09535306,-0.0008458101,0.04009673,0.015120833,-0.06060974,0.105651066,-0.05699021,0.005267202,0.011567774,-0.09179941,-0.022096943,-0.03527136,0.080031306,0.02585418,-0.029881814,0.015792876,0.014906761,-0.0046204873,-3.763654e-33,0.053027164,-0.06928452,0.01707859,-0.12927765,-0.06923065,0.083916135,-0.020938722,-0.043191653,-0.0036794855,-0.0463376,0.10274849,0.019786421,0.05762606,-0.042872395,0.0493922,-0.027717203,0.04323105,0.037397478,0.05117662,-0.013862402,0.08488087,-0.016024789,-0.030538568,-0.011023607,-0.0039011524,0.017072702,0.008415647,0.015354679,-0.012416238,0.012378811,0.012751606,0.011611942,-0.03679495,-0.046909757,-0.123064116,-0.020911105,-0.040739276,-0.030739743,0.023181478,0.0010777627,0.007022248,0.00803348,-0.011269941,0.020282777,-0.0026566654,-0.015985807,-0.06548537,-0.050304648,0.019265432,0.023574192,0.010121625,-0.107579544,-0.055026412,-0.060342338,0.007952619,0.07587786,-0.0063457843,0.05549133,0.017866988,-0.018752066,0.014902141,-0.016714063,0.046914443,-0.040285066,0.057789933,0.017684126,-0.012442722,0.030111648,0.004641879,0.046639968,0.036161065,0.039515827,-0.00640029,0.05700851,-0.010475885,-0.047244437,-0.05280961,0.002712456,0.015018226,-0.059353936,-0.017157724,0.016697612,0.10709802,-0.03467334,0.062112905,-0.060747392,0.0723061,0.017818376,-0.02195063,0.051997177,-0.019817108,-0.029368509,-0.053740315,-0.005236237,0.021961752,-3.9662098e-08,0.029290492,-0.015172537,0.056781895,-0.035287548,-0.006170446,0.103565276,0.001563329,-0.014135092,0.04264471,-0.038698938,-0.009755777,0.06095764,0.06282541,0.04761107,-0.044162206,0.0643251,-0.056207635,-0.016984062,-0.016398933,-0.078784294,0.014069238,-0.08963826,-0.0039891955,0.06605297,0.029080037,-0.01475956,0.031488985,0.10195494,-0.036528792,-0.05541493,-0.0769141,-0.00048288715,0.005985486,-0.050451644,-0.04066594,0.018597662,2.5260445e-06,-0.038117163,-0.062237155,-0.015225849,0.027811132,0.044582527,-0.026025092,0.021856159,0.07377483,-0.0011065203,-0.038948197,0.05686491,-0.0015457752,0.03831514,0.07134371,-0.021127159,0.03728715,0.0053159436,-0.042498566,-0.03414047,-0.020100407,-0.030341636,-0.03223569,0.0356221,0.058564957,0.026955089,0.07748113,-0.05572096 +1.1.1.439,"The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs.",384,0.99999994,-0.021601625,0.030361963,-0.15672016,-0.015073999,0.0004096765,0.071153164,-0.025565317,0.0752638,0.08855826,-0.01853271,-0.02186659,0.031419825,0.005384038,-0.024350429,-0.11073316,0.09678441,-0.0869061,0.03633973,-0.019218432,-0.03998015,-0.0021198615,0.04466748,0.063437566,0.059476614,0.010517099,0.01581453,-0.028134495,0.029965872,-0.007809125,0.0031851958,0.058590554,0.045691114,0.0073312926,-0.038602803,-0.0532352,0.030301655,-0.061325092,0.01781507,0.000496359,0.08909396,0.025775896,-0.04048369,-0.07737394,0.021105284,0.032544196,-0.057897683,-0.011885036,0.01648381,0.0513973,-0.021342855,-0.05753054,-0.035818253,-0.057632986,-0.009198589,-0.04706585,-0.09514153,0.005301885,0.070851006,-0.0053115576,0.03222751,0.11002438,0.0059699463,0.018147865,0.05304316,-0.045690786,-0.061744157,-0.043151386,-0.015941782,0.047650777,-0.08861441,-0.004670098,-0.061737612,0.007029147,-0.024787692,-0.053623356,0.03852851,0.027478412,0.029312395,-0.0013114568,-0.055930987,-0.0059617367,-0.0130865825,0.014192435,0.09418951,0.058244333,0.08933148,0.038070377,0.019722728,0.04782107,-0.011868453,0.06556838,-0.01686101,-0.041848466,-0.006211723,-0.096826695,0.02290851,0.007797229,-0.04468494,-0.01290939,0.019161543,-0.016211202,-0.01947454,-0.09046708,-0.048159987,-0.08395603,0.017948603,-0.04629649,0.035022378,0.016413016,-0.022328626,0.004524093,-0.0025862642,-0.023832709,0.042253923,0.017865967,0.093241006,0.058318663,-0.028594686,0.01819383,-0.0006707915,-0.10301185,-0.025557373,-0.01161338,0.03398366,0.0151858935,0.019083329,-0.05282182,3.179212e-33,0.07256932,0.06840395,-0.038060315,-0.025424264,0.009140537,-0.032264814,-0.13215943,0.013210312,-0.06683075,-0.066606686,-0.07130186,-0.013744004,0.03418643,0.03636762,0.00825379,-0.015410615,0.012099536,-0.020891335,0.044112798,-0.05815178,0.0033097214,-0.0065864334,-0.07538,0.012484367,-0.022316273,0.09756291,0.03597784,0.027600938,-0.020921847,-0.0055658,0.010401672,-0.104102574,-0.046874836,-0.005445556,-0.0042711115,-0.008215001,-0.015824314,-0.037586305,-0.00466448,0.10097674,-0.00045323715,0.017088247,0.052973658,0.008685161,0.10613639,-0.014051322,-0.033519432,0.17519209,0.07299903,0.028085021,-0.021084908,0.051699318,0.14644262,0.02387826,-0.09762957,0.028550623,-0.009410393,0.016815204,0.034338985,0.04142998,0.002213719,0.012311584,-0.020979023,0.042870596,0.006347348,-0.0052095368,-0.024574414,-0.03624539,0.07681297,0.04491148,-0.08807971,0.030644083,0.044348806,0.033861525,0.050530497,-0.026231848,-0.006568342,0.035982557,0.01209067,0.057145663,-0.04742089,-0.059910245,-0.0074913804,0.009700762,-0.06337565,0.025005344,-0.021420462,-0.04538214,-0.033477426,0.031811815,-0.026748072,-0.0043492294,-0.07834114,0.014525893,0.04709402,-3.2816037e-33,0.06286334,-0.06155049,0.04415528,-0.041360788,-0.012285419,0.055426806,-0.049550496,-0.012654627,0.02130071,-0.010989628,0.035868134,-0.018010372,0.11307835,-0.009818459,-0.037321117,-0.022027245,0.04234423,0.068725854,-0.027591715,-0.025975136,-0.093225464,0.1252377,-0.055899616,0.017079746,-0.0006418617,-0.026633589,0.014995962,-0.021774488,-0.03702591,0.06914872,0.059979964,-0.009500363,-0.0778251,-0.04407612,-0.02922506,0.08253439,-0.032374714,-0.00640793,-0.0029234078,0.05683244,0.052052464,-0.004581279,-0.017153563,0.08403193,0.027562667,0.0094038155,-0.0923014,0.1266327,-0.019209906,-0.034077827,0.026453873,0.038361978,0.07742675,0.015992094,0.08930365,-0.025760226,-0.027031293,-0.06961134,-0.037534315,-0.0077209137,0.0015389037,-0.06271166,0.019120695,-0.031108381,-0.02311656,0.07747755,-0.028728947,0.016108815,0.08408277,-0.04331056,0.0990108,-0.02751108,-0.018205477,0.09495842,-0.08523612,-0.0026912657,-0.0044862027,-0.070505865,0.0031209507,0.015307758,-0.04595588,-0.01753845,0.023033729,-0.07399188,-0.037758633,0.021846928,-0.037438545,0.08747562,-0.0067798514,-0.01773316,0.010989646,0.02606491,-0.07453901,-0.02916506,0.051066168,-3.589915e-08,0.070427634,-0.039391678,0.05542922,-0.007838343,-0.047618665,-0.03636404,0.032103375,0.0074615586,-0.0076101,-0.0010592066,-0.043117587,0.07953705,-0.01686484,0.014715837,0.03981929,0.04035195,0.1283965,0.02256011,-0.034333255,0.015157201,-0.048344847,-0.0037142425,-0.039421882,-0.08021412,0.017905354,-0.11132117,-0.0013769204,-0.035422195,0.03515054,0.019472485,0.04504522,-0.012390793,0.026072005,-0.047143318,-0.037493944,0.09693101,0.016533758,-0.03803737,0.039436568,-0.02672479,0.016345162,-0.052075516,0.0027362625,-0.010358196,-0.103691936,-0.011361697,0.0455341,0.031019948,-0.015922097,-0.06733145,0.022846218,-0.002364039,0.039451227,-0.08931579,-0.1353691,0.014949691,-0.008164717,-0.098309554,0.037462775,-0.085262306,0.008237816,-0.036978543,0.1969671,-0.08287471 +1.1.1.440,Isolated from the plant Alstonia scholaris (blackboard tree). ,384,1.0,-0.008796526,-0.011292382,-0.114660874,0.01626695,0.0522757,0.022601001,-0.034641024,-0.018661011,0.04076386,0.01486416,0.102609396,-0.02462206,-0.05464454,-0.04398299,-0.16026543,0.05538767,-0.051204678,-0.031964716,-0.01347283,0.044514894,0.040459003,0.1194566,-0.0062464694,-0.00018730396,-0.03162877,-0.011625536,-0.08081587,0.039977856,0.04701312,-0.102082856,-0.03202841,0.013306423,0.07726524,-0.0053934655,0.057048813,0.054658487,-0.03574413,-0.046774596,0.07661239,0.045488883,0.025203975,0.017079385,0.038107842,-0.008828907,-0.071525484,0.024949107,-0.082809255,-0.028055375,0.067284755,-0.0030840964,-0.008287891,-0.08812214,-0.045657896,0.02359104,-0.047014643,-0.010768319,0.037686955,0.00097622524,0.032198373,0.0399642,0.09456695,0.069830716,-0.012212082,-0.00078813947,-0.031915236,0.071118,-0.09150378,-0.025858497,0.093822576,-0.03491243,0.064730234,-0.013369606,-0.007832642,0.012369991,-0.014144554,0.027723312,0.02114853,-0.025168544,0.04259329,0.047051687,-0.016947726,0.07199737,0.018908486,-0.011467905,-0.0010266495,0.011549068,-0.009007537,0.11007499,-0.037585974,-0.058977317,-0.01463843,0.038579505,-0.014463488,-0.07614262,-0.023455292,0.0136069,0.031047668,-0.049326554,0.0042002653,0.028401734,-0.036812756,-0.03464738,0.105164565,-0.1301138,-0.1156516,-0.0012091768,-0.063129306,-0.063665,0.103306845,-0.03583284,-0.076246805,-0.0048313322,-0.08481229,0.046123058,-0.0020188582,-0.0027160214,0.0962631,-0.018425735,-0.019639535,0.025281046,-0.023465915,-0.009024287,0.11592035,-0.002393286,-0.00033161612,0.011854761,-0.101869844,-1.7504962e-33,0.0412212,-0.027227575,-0.010267672,-0.06881768,0.13046266,-0.049341746,0.031098925,-0.017706415,-0.06758407,-0.005107694,-0.11193381,-0.055194706,0.014352977,-0.018738173,0.03065574,-0.017979575,0.008031023,-0.021315942,-0.00046241362,-0.004252156,0.0385169,0.06910155,-0.00865535,-0.033152256,0.012470315,-0.053840395,-0.02021187,-0.019430947,0.13613723,-0.01029308,0.028643003,-0.116905265,-0.06626836,-0.053538103,0.03955889,0.07301027,-0.02641181,-0.053594086,-0.016168036,0.04151304,0.007581098,0.007994356,0.08297936,0.016514571,0.04351426,-0.0034986746,-0.04079101,0.013810942,0.09073643,-0.08026693,-0.044454623,0.008296812,0.055494573,-0.04184828,-0.036902975,-0.02877594,0.004421069,0.10978233,0.05935533,0.026745362,0.081931375,0.04084642,-0.0054638544,-0.008322313,0.061470132,0.06976993,-0.11523841,0.010331391,-0.03255665,-0.100561164,-0.032600757,-0.062632106,-0.03202575,-0.0814465,-0.0340449,0.01998777,0.011110835,-0.010168441,-0.027766706,-0.010904826,-0.07602713,0.012863587,0.022781821,0.0130341565,-0.02233556,-0.01246639,-0.03496993,0.059584454,-0.028553719,0.0002877776,0.022908533,0.0025280358,-0.1091805,-0.02653847,0.065107405,-4.382219e-34,0.030511448,-0.03823245,0.041224424,0.0031030618,-0.04498159,0.12883468,-0.07169863,0.069745086,-0.026125632,-0.024650728,0.029537708,0.058011696,0.034633182,-0.030639682,0.023338968,0.059692256,0.045089774,0.1713665,-0.031211026,-0.04663996,-0.01266818,0.08821053,0.010169379,-0.06968598,-0.014153744,-0.016873457,0.030372197,0.042590544,-0.04603024,-0.011440719,0.020771336,0.015145935,-0.05702406,-0.06711077,-0.07326282,-0.0370378,-0.09366453,-0.1373433,0.0009644984,0.022192894,0.0339253,0.023350326,0.053580806,0.085835695,0.078747466,0.009868989,-0.040695872,0.022019796,0.0115119135,0.027673017,0.018007118,-0.03942517,0.023988716,-0.017400423,0.041170154,-0.007915339,0.039622236,0.05149851,0.001558618,-0.009007141,0.028333878,-0.042973008,-0.09234986,-0.002739378,0.051913373,0.08203203,-0.026112484,-0.002901208,-0.023245899,-0.038706806,-0.0038560403,0.05806069,-0.012862309,0.10310555,0.027487012,0.08112772,-0.029416896,-0.01996404,0.019633198,-0.013146905,0.0013821676,-0.03004893,0.037283402,-0.047437143,0.0794445,-0.060292404,0.056474764,-0.007665918,0.017573606,-0.049955644,0.007979601,0.047820557,-0.054402187,0.024011709,0.06862895,-1.7944236e-08,0.06920503,0.023149423,0.03070549,-0.061072923,-0.025784038,-0.051392574,0.051957555,0.012789357,0.009576204,-0.016339647,-0.053954605,-0.049911093,-0.0186985,-0.025459321,0.04285296,-0.01751707,0.0854978,0.07490532,0.0098696975,0.013954187,-0.022012563,-0.030679993,0.059897743,0.037053157,-0.07185061,-0.0921098,0.08594135,-0.0014320121,-0.007625746,-0.05005876,0.03332902,0.101699114,-0.039104834,-0.028441995,-0.032400507,0.067958504,-0.04159559,0.008704173,-0.043017957,0.007664214,-0.002085944,-0.058574356,-0.035806812,-0.04259272,-0.03762218,0.0017118887,0.023217263,0.040802356,0.01272822,-0.025886787,0.020796519,0.015323536,0.03998199,-0.007001927,-0.05666057,-0.044450387,0.055954657,-0.03703243,-0.019779673,-0.025473785,-0.02456662,-0.047664855,0.080215074,0.05306384 +1.3.1.127,The enzyme has been charachterized from the plant Rauvolfia serpentina.,384,1.0,-0.047837928,0.00088174583,-0.15988007,0.043589704,0.03628426,0.0531155,-0.11063479,-0.009616997,-0.05737739,-0.008939475,0.04466602,0.0005239503,-0.008658447,-0.05255983,-0.13677722,0.06418214,-0.00645506,0.045680933,-0.056556504,-0.02730033,0.059557535,0.021320883,-0.018298538,-0.007907702,0.09282405,-0.017952925,-0.059095636,-0.036810283,0.019852627,-0.063250534,-0.03336525,0.026941145,0.046115458,-0.07523798,0.035803415,0.07294164,-0.08004135,-0.08267473,0.061020065,0.04413139,0.08875905,-0.017120043,-0.045733936,-0.0021968987,-0.060935143,-0.016417813,0.014784967,-0.000261106,0.09249306,-0.048779707,-0.05691332,-0.0072896234,-0.06074818,-0.038505998,-0.10736832,-0.052516624,0.016650274,-0.02248783,0.0064606545,0.054392308,0.0378004,0.045719165,-0.018093813,0.053337596,-0.006772884,-0.07272069,-0.024537934,-0.024464726,0.0788283,-0.055600706,0.0051139696,-0.044798687,-0.0005351777,-0.016252795,0.00478045,0.05129193,0.0612507,0.001461715,0.027384793,0.009962203,-0.012011883,0.015770348,0.09556818,0.02087129,0.09411496,0.088817336,-0.009907947,0.058681566,-0.011000329,0.028162798,0.09264022,0.024016842,-0.019496612,-0.0536041,-0.026688214,0.03488899,0.031316645,-0.06100576,0.022052484,-0.028789561,-0.06120493,-0.06257924,0.04395281,-0.07060044,-0.044149052,0.03614322,-0.061749768,-0.016782813,0.05155049,0.025588239,-0.021807106,0.0076753376,-0.020556383,-0.0036458604,0.025436703,0.10065909,0.0033940335,-0.054999925,-0.028317109,-0.035328634,-0.010609765,-0.049560327,0.047356654,0.010215969,-0.013773583,0.015730264,-0.0869911,8.487774e-34,0.011468816,0.028110852,-0.083645955,-0.019537248,0.03584894,0.015365227,-0.06693704,0.040449217,-0.0567854,-0.034539446,-0.09035423,-0.04305085,0.0017632053,0.023335513,-0.052708477,-0.019520404,0.08004437,-0.06048623,-0.002808403,-0.040562496,0.06214065,0.04583586,-0.056470193,0.013486118,0.0028780468,0.012009695,-0.02130486,-0.011948887,0.038020432,-0.008602719,0.049282502,-0.10084933,-0.043812465,0.04562431,-0.017580926,0.028955145,-0.028608764,-0.083556816,-0.027904164,0.059224363,0.02315031,0.07981247,0.04615866,-0.008127231,0.082793966,0.003563697,-0.052259266,0.05031804,0.05193761,0.035734966,-0.021515781,0.044660907,0.12281408,-0.0018092337,-0.07816555,0.015309203,0.01136788,-0.008854329,0.050842993,0.0016387192,-0.027227513,0.05278495,-0.015568929,0.025349936,0.02645976,0.033281527,-0.06135993,-0.02823832,0.051336836,0.016217316,-0.07398483,-0.00054955645,-0.02218862,-0.011534638,0.061674908,-0.0024587538,-0.013089847,0.0129047865,-0.04758956,0.0041796626,-0.0012494397,-0.0025360899,0.012808599,-0.014999842,0.010608326,0.017393926,-0.03922558,-0.040370926,0.027875507,0.025313716,0.09266029,-0.07040583,-0.039949547,0.033029284,0.033492018,-1.0295699e-33,0.06712571,-0.09175493,0.056980953,0.016585903,-0.06758172,0.059445564,-0.03415808,0.009233449,-0.052955724,-0.03237823,0.05971102,0.0018730987,0.022764111,-0.016495124,0.02063608,0.042408843,0.06516314,0.08559814,0.0012429721,-0.0128422,-0.13636503,0.109496795,0.018681582,-0.1045355,0.053518243,-0.07848058,0.06612878,0.005252739,0.04005239,-0.015914386,-0.03166286,0.031180378,-0.060871087,-0.014477082,-0.058643192,0.022896644,-0.06436891,-0.0075966935,0.030663963,0.095435984,0.09286978,0.00703079,-0.06960711,0.051519215,0.0061996616,0.044398226,-0.04036755,0.048934016,0.019466635,-0.038498733,0.08920507,-0.029588828,0.04502188,0.020574525,0.045519374,0.05643219,0.10027644,0.011045898,-0.05611484,-0.014295058,0.032628655,-0.0351097,0.008439054,-0.020095455,0.015064806,0.19744952,0.029716417,0.05784311,-0.013717373,-0.0020494754,0.051949915,0.065533996,0.01612955,0.107149154,-0.011227082,-0.003989802,-0.038610477,-0.053829893,-0.05248774,-0.05940927,0.011164725,-0.008426741,-0.0066794613,-0.111205734,0.019898362,-0.052633643,0.024300985,0.094499595,0.01643133,-0.014990137,-0.008641108,0.009081793,-0.046040114,0.034566645,0.16817841,-2.3213635e-08,-0.004061006,-0.012304602,0.04377451,-0.060307194,0.033097163,0.02054807,0.045725115,-0.060682636,-0.010284722,0.026747825,-0.06873076,0.10793223,-0.030006692,-0.018821502,0.010282422,0.029103141,0.023953922,0.028798962,0.026729908,0.009785304,-0.026637578,0.030124333,-0.08719307,0.004433891,-0.038781673,-0.09384719,0.006948805,0.02266079,0.023881061,-0.054220047,0.028197015,0.04773109,0.0401849,-0.06626343,-0.105334975,-0.0028883365,-0.02538652,-0.06547932,0.005307779,-0.037758254,0.08357196,0.00983852,0.025025576,-0.0016593117,-0.06667168,-0.011903696,0.028682925,-0.01753728,0.047417384,-0.032659993,0.045448452,0.01959634,0.034378402,-0.09233446,-0.059267126,-0.05983503,0.025713243,-0.0453575,-0.0709074,-0.024304878,-0.044160943,-0.04683373,0.16827287,-0.0430571 +1.3.1.128,"The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs. The enzyme forms the iminium ion form of dihydroprecondylocarpine acetate, which spontaneously rearranges and undergoes deacylation, producing dehydrosecodine.",384,1.0,-0.04497886,-0.030471455,-0.13292883,-0.014975352,-0.025469303,0.030454936,-0.01315976,0.070601,0.08275705,-0.0024008616,0.04164623,0.013599763,-0.036894143,-0.02630075,-0.10506528,0.07562231,-0.08383436,0.00072817015,0.019176772,-0.011853141,0.00908306,0.015247125,-0.0077557284,0.035094753,0.04514025,0.027825698,-0.016908774,0.037063513,-0.01896796,-0.035834506,0.054502863,0.014201554,0.030837916,-0.021249166,-0.026789019,0.038163323,-0.08681701,0.013501314,0.049296737,0.10651156,0.014546857,0.011452954,-0.084903106,0.029043538,-0.025283858,-0.057589084,-0.066402204,0.060753968,0.02453055,0.018369762,0.0052927197,0.0015836147,-0.038342297,0.018469727,-0.04336518,-0.09623458,-0.0075818673,0.119685635,-0.015642656,0.08668021,0.12182419,0.025515314,-0.020526836,0.021794466,-0.039194055,-0.055510454,0.00055145146,-0.010041409,0.07035522,-0.11399823,-0.0072895265,-0.07323218,0.0080895955,-0.047118876,-0.039864983,0.013345866,-0.0289431,0.016342942,-0.032081418,-0.02752398,0.050418414,0.018291645,-0.005875738,0.07618462,0.04861943,0.08754822,0.018570201,0.0073329858,0.0641416,-0.03844809,0.05605408,-0.04571216,-0.059489295,-0.04733359,-0.09076816,0.057537448,0.04787329,-0.01149858,-0.035129867,0.007270767,0.04163405,0.005766072,-0.12885186,-0.081733726,-0.09301208,0.022554025,0.010948574,-0.016606176,-0.011967882,0.012924817,-0.016494878,-0.008413788,-0.027728429,0.072468944,-0.016028693,0.108844995,0.065878876,-0.039017387,-0.010122103,-0.009254469,-0.075231664,-0.047236208,0.027651468,0.05773359,-0.010232464,0.011127413,-0.050775677,4.0340097e-33,0.036900047,0.040169857,-0.015651772,0.0070635225,0.029287102,-0.04226638,-0.11914215,0.08013544,-0.05122687,-0.08700472,-0.06653844,-0.019949444,0.039751165,0.025890999,-0.042388372,-0.0446642,0.012071173,0.010437462,0.076772526,-0.03736873,0.02062884,0.019896913,-0.06506418,0.0019459716,-0.022460375,0.085857786,-0.041525837,0.043999095,0.06803002,-0.015777325,-0.00471975,-0.12599684,-0.04263454,-0.016841682,0.011958978,-0.001842536,-0.054587755,-0.00011382427,0.011311984,0.056270607,0.023741731,0.032433275,0.020964144,-0.0026733475,0.08397717,0.002063042,-0.0060244636,0.11547691,0.026470771,-0.014309901,-0.006595126,0.0031518098,0.11803026,0.024307553,-0.09109962,0.05184131,0.002892358,-0.005811779,0.025921313,0.06511395,0.044112314,0.033365723,-0.055745553,0.025425138,-0.0043338733,-0.05393011,-0.06626171,-0.0051134066,0.08588417,0.06339846,-0.109157406,-0.00501156,0.02373851,0.018087592,0.055041205,-0.0055368366,-0.043209236,0.05679657,0.012731732,0.010094191,-0.01974987,-0.04318076,0.016465528,-0.0014157139,-0.03546545,0.013799998,-0.021544363,-0.061059706,-0.055820037,0.08439435,-0.0081329,0.0015931685,-0.057337943,-0.020407572,0.13362364,-4.408525e-33,0.070503384,-0.071279116,0.041474268,-0.06941205,-0.0012367403,0.100522295,-0.0010186651,-0.0031328788,0.033200696,-0.011902136,0.0064881137,0.0010659005,0.041437272,-0.022024542,-0.03802896,-0.015015519,0.024484232,0.0818292,-0.036397185,-0.046705354,-0.08533114,0.09488801,0.015450768,0.027714783,-0.0025079064,-0.03274354,0.04522134,-0.014286076,0.013036588,0.082160674,0.030019132,-0.0036660284,-0.06828129,-0.029924633,-0.064637765,0.08526857,-0.07717671,-0.0030383666,-0.038094547,0.049657576,-0.0032636458,0.00059257937,-0.018736599,0.04838581,0.04595499,-0.00764201,-0.09786389,0.11461723,0.0122824395,-0.016806217,0.071827315,-0.0021845219,0.001394946,0.03937789,0.0996291,0.0015003537,-0.001816821,-0.042106126,-0.05050956,-0.003989526,-0.033426814,-0.066616185,-0.028781073,-0.04917622,0.022397771,0.015172415,-0.008244749,0.0722126,0.07626375,-0.0352751,0.07855295,-0.003284141,-0.04706463,0.035108175,-0.07771494,-0.03189715,-0.022231208,-0.083196856,0.029947512,-0.054464716,-0.0678908,-0.016071862,-0.014729585,-0.0674133,-0.057230834,-0.04795269,-0.015035016,0.07007557,-0.023300337,0.028894385,0.036444627,0.014996259,-0.043142874,0.028190263,0.048312116,-4.2346755e-08,0.06886867,-0.06550597,0.05198739,0.024384085,-0.015311302,-0.03799909,0.042536855,0.007051555,-0.010037192,-0.037471298,0.0058566835,0.076269284,-2.382497e-05,0.06259881,0.05039754,0.035871595,0.11175656,0.037632633,-0.03238527,0.037197825,-0.038170148,-0.0133198425,-0.08829909,-0.05238714,-0.0075162835,-0.095006615,0.008091879,-0.0003719197,0.05141106,0.019052127,0.06682352,-0.013100576,0.021734994,-0.09226935,-0.025954438,0.06344681,-0.010246004,-0.012186171,0.029769126,-0.023084663,0.038450956,0.006766764,-0.056042053,0.017882422,-0.074090056,-0.001034931,0.016585266,0.04611068,0.008807657,-0.0022926605,-0.003901538,0.018716082,0.06501823,-0.09442035,-0.1097405,-0.004061774,-0.03937024,-0.08272993,0.017716225,-0.101595275,0.0080165025,-0.01686345,0.2267598,0.017643597 +1.5.1.56,"The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs. Both the substrate and the product of the enzyme are unstable.",384,0.99999994,-0.018834453,0.021161197,-0.15480831,-0.023685222,0.0051052277,0.07090553,-0.0343098,0.08306487,0.08253756,-0.023459675,-0.01579875,0.03341229,0.0070446767,-0.02234205,-0.11563474,0.09390121,-0.09233761,0.03736399,-0.016779497,-0.03694952,0.0007258003,0.038671184,0.051352363,0.05255342,0.012819537,0.012987201,-0.022407617,0.028855309,-0.008868759,-0.0071549993,0.050821934,0.039549343,-0.0035756186,-0.032572843,-0.050393905,0.031201536,-0.06175712,0.018810656,-0.003027936,0.093055,0.025615098,-0.038057733,-0.07877031,0.019434715,0.031074254,-0.049067486,-0.0065074065,0.018910877,0.04596355,-0.018723259,-0.06316402,-0.043614503,-0.043963317,-0.015105921,-0.045750797,-0.100146934,0.007685146,0.081689514,-0.007327153,0.03148058,0.11995636,0.011226153,0.004595144,0.047294587,-0.035994947,-0.06675236,-0.032212976,-0.018247738,0.046535306,-0.08349452,0.0016261885,-0.061982315,0.0038251225,-0.030479416,-0.04604028,0.04026363,0.023602508,0.022214934,0.008849923,-0.051452313,-0.0077590477,-0.014612542,0.0073557273,0.09166633,0.057596836,0.087066285,0.04579777,0.013738438,0.050736226,-0.0071911328,0.06475951,-0.0070856833,-0.043296944,-0.008507449,-0.09316393,0.030755073,0.0124126235,-0.04172517,-0.012263083,0.021777608,-0.0148560135,-0.011451894,-0.085648865,-0.037653923,-0.08666376,0.020988189,-0.04937179,0.040033586,0.014991136,-0.02131788,0.008663277,-0.00079589686,-0.014062016,0.04821825,0.012330259,0.10269392,0.05807246,-0.029656438,0.01196177,-0.0077316915,-0.09483192,-0.01868668,-0.0033892388,0.039887544,0.013321677,0.009853696,-0.047572322,1.777036e-33,0.06960023,0.056527745,-0.049023956,-0.03103017,0.0032376044,-0.035947982,-0.13478827,0.017215712,-0.07122839,-0.06465071,-0.06742553,-0.021334667,0.031549696,0.035049044,0.010453137,-0.018944731,0.021299867,-0.019105742,0.041057818,-0.051386535,0.008043888,-0.014019481,-0.07922109,0.012994844,-0.026899705,0.096793726,0.040969007,0.033292398,-0.028834555,-0.0037882633,0.007406817,-0.108102106,-0.0515549,0.003286957,-0.00014213099,-0.010326438,-0.018333638,-0.024560379,-0.0036864073,0.10281157,-0.008767513,0.022680856,0.061751224,0.010564647,0.114914775,-0.029463984,-0.033299062,0.17678541,0.06273423,0.030612532,-0.020318206,0.04965427,0.14364605,0.025854506,-0.09732916,0.032936055,-0.0038572093,0.007963076,0.025462583,0.031051727,0.0076206494,0.012968761,-0.025100427,0.042331327,0.008399548,0.0031616748,-0.034809813,-0.036279906,0.071696274,0.05265823,-0.08430935,0.028521512,0.048530508,0.02718546,0.040259782,-0.031232618,-0.01687998,0.04417818,0.010741801,0.055920567,-0.042098098,-0.06702036,-0.012405438,-0.00025962628,-0.07308761,0.025619771,-0.019467033,-0.05077065,-0.032879304,0.045551546,-0.022932377,0.0009880498,-0.08068433,0.018272577,0.055648178,-1.8606702e-33,0.060785223,-0.0653053,0.0434345,-0.04199362,-0.015864663,0.054223333,-0.041275192,0.005284959,0.010540796,-0.017085038,0.03058742,-0.021309905,0.09837544,-0.00071033015,-0.032562263,-0.01376517,0.041360866,0.08271128,-0.020087102,-0.025021257,-0.095888056,0.13599724,-0.056677092,0.021346115,0.0070798285,-0.030512884,0.0049532987,-0.020069582,-0.033103053,0.075139426,0.0600219,-0.011468352,-0.07414271,-0.038960837,-0.022164917,0.08528473,-0.033895627,-0.009842146,0.0034873853,0.06158107,0.05220585,-0.0026611905,-0.012802979,0.07997512,0.038071305,0.014607713,-0.085629635,0.12445392,-0.016458204,-0.03698981,0.03408565,0.041041344,0.085248716,0.019515619,0.09038215,-0.009775376,-0.020228492,-0.062993795,-0.037763577,-0.00501437,0.0016723945,-0.0638106,0.016964367,-0.03680805,-0.013444162,0.07770116,-0.03572506,0.02660093,0.092452735,-0.042948622,0.10673991,-0.03345747,-0.01578327,0.092120856,-0.08352765,-0.00720409,-0.016036162,-0.05600611,0.0042443206,0.005072047,-0.046172135,-0.001908407,0.023400271,-0.07516625,-0.03374563,0.016461836,-0.039812528,0.09085059,-0.0054546143,-0.017978854,0.013745271,0.025173886,-0.08022108,-0.02309665,0.061849423,-3.551518e-08,0.06704806,-0.046257857,0.047802363,-0.011668325,-0.04627543,-0.033749793,0.039964136,-0.0009406115,0.0012712739,-0.00057581754,-0.04521046,0.0828089,-0.026447415,0.016073784,0.035024583,0.03790958,0.113912456,0.019925235,-0.037689682,0.013674606,-0.052432127,-0.009819602,-0.048451297,-0.07993028,0.00460728,-0.10800131,-0.0020305284,-0.026836378,0.030301757,0.021365967,0.040650528,-0.005956362,0.022190219,-0.051859982,-0.040364288,0.09968902,0.010863431,-0.03281616,0.03955156,-0.027813306,0.016810678,-0.051917322,-0.0037534474,-0.005730302,-0.087446414,-0.012680397,0.050533764,0.023252942,-0.011338328,-0.05458247,0.017738534,1.7549268e-05,0.044824213,-0.08849263,-0.13691998,0.009048217,-0.0004389913,-0.10239893,0.03539871,-0.08750079,0.013300703,-0.03679941,0.20220186,-0.08246676 +1.5.3.27,"Contaions FAD. The enzyme also acts, with lower efficiency, on 2-aminoethylphosphonate, generating phosphonoacetaldehyde and ammonia. The enzyme from Acinetobacter baumannii also transformed 2-(dimethylaminoethyl)phosphonate with appreciable efficiency, generating dimethylamine in place of methylamine.",384,1.0,-0.11472823,-0.03818642,-0.09555536,-0.05759628,-0.004482203,0.0055972007,-0.0150941,0.078253314,0.023206461,0.02728701,-0.0011607498,-0.06194394,-0.020712629,0.03466091,-0.023893466,0.09121155,-0.059855103,0.0014634843,-0.09169972,-0.046403524,0.02768039,0.055516288,-0.026102515,-0.046137996,0.07044458,-0.0078306245,-0.04444317,-0.026425319,0.0646563,0.022677211,0.0073885643,0.04666579,0.020721653,-0.05488473,0.04035483,0.07200077,-0.019994562,-0.038412012,0.11820222,0.011368783,0.06446882,0.092379846,0.023042215,-0.02317582,-0.076029584,0.025853842,0.013339781,0.060599856,0.028932558,0.003633777,-0.02066538,-0.029321194,-0.005320371,0.019879181,-0.028348237,0.10110296,-0.06112564,-0.010583137,-0.0087046325,-0.02253935,0.03255958,0.025808105,-0.0007187075,0.013757305,0.04494354,-0.061928585,0.011051266,-0.074070685,0.04791476,-0.03616853,-0.0067029702,-0.041803826,0.012044797,-0.0156085035,0.027990386,-0.013088994,-0.0031870832,-0.014936343,0.022952043,-0.032635186,0.01154595,-0.053653736,0.05503281,-0.0034822286,0.05443433,-0.031220386,0.037672732,-0.017912824,0.023006413,0.032487504,-0.0153516065,0.0051413076,0.029029502,-0.14300683,-0.09337014,0.044141077,0.009674037,0.032117322,0.0230393,0.034090582,0.0016955386,0.05906341,-0.037844937,-0.11225991,-0.06345368,-0.12534796,0.03212935,0.07255986,-0.017419944,0.040638715,0.020266796,0.009948804,0.096130624,-0.019642802,-0.0015399227,0.025987087,0.0030452185,-0.023157703,-0.031873345,-0.014639168,0.010222109,-0.043612868,0.040969662,0.041916765,-0.019115886,0.039021976,-0.12889144,5.6376985e-33,0.019708874,0.028170804,0.0170518,-0.054558378,0.07946479,-0.013323178,-0.14007422,0.049654897,0.03498393,-0.09665049,-0.041332204,-0.042341232,0.058768477,-0.017584598,0.005451575,-0.025853155,-0.025512516,0.02449489,0.05155961,-0.018743543,0.041592434,0.11584923,0.036815893,0.058280583,0.026262268,-0.041833874,-0.017173838,0.07908853,-0.029628022,-0.003924262,0.013005613,-0.049255352,-0.08501986,-0.041845743,-0.026188936,0.020331841,-0.09743221,-0.056477897,-0.048267927,0.07066768,-0.0016852304,0.035942238,-0.000913672,0.02169312,0.05667841,0.010729612,-0.06393049,0.06972501,0.016258642,0.010078387,-0.010898134,0.01581693,0.03616884,-0.024848368,-0.015533865,-0.017799783,0.043269902,-0.071947604,0.057437398,0.03853799,-0.012776126,0.0054375627,-0.062203504,0.052142084,-0.061815947,-0.041641157,0.018049272,-0.049977362,0.053571276,0.08081255,-0.04539781,-0.023909967,0.016836824,0.021207392,0.031692993,-0.059567425,-0.0009130366,-0.105293274,-0.020815091,-0.014084957,-0.017553821,0.037114345,0.08556697,-0.040817816,0.009405398,-0.13551396,-0.045423392,-0.045453105,0.033204675,-0.035691645,0.023528317,-0.050392378,-0.053463746,-0.014691536,0.003637845,-5.7245796e-33,0.045957007,-0.047208752,0.033643674,-0.057792075,-0.04115958,0.09253142,0.050816193,0.03474479,0.02180185,-0.08524061,0.09818259,-0.0073969974,0.008434536,0.018020697,0.01787316,-0.016341444,0.036078963,0.03948393,0.019808544,-0.014497966,0.046767715,0.07584508,0.046788692,0.02142728,3.745074e-05,0.0077492874,-0.079689026,0.042488255,-0.0021889973,0.09711759,-0.051577035,0.012467596,-0.056588367,-0.054468557,-0.0870188,0.045582756,0.0031537465,-0.0056170733,-0.021271326,-0.004265679,0.032602828,0.031817634,0.021894583,0.06679756,-0.039377727,0.027243495,-0.067619726,-0.066903576,-0.03728444,-0.06776395,0.081891894,-0.010632838,0.038359124,-0.062643796,0.03289726,0.007610052,-0.0052485047,-0.03400267,0.0020711932,0.016710741,-0.014181084,-0.10419917,0.032240827,-0.0025861966,0.009550732,0.08286366,0.036129896,0.1360838,0.038773775,-0.018576914,0.025711015,0.055651385,-0.014415214,0.103324525,-0.09905212,-0.023638556,-0.0031773618,-0.039935146,0.007931044,-0.014301003,-0.013887648,0.0007133883,-0.043763794,-0.049649704,-0.050741237,-0.04033672,0.06865256,0.06171564,-0.014481483,0.06274147,-0.060185708,0.06501451,0.048261568,0.04412028,0.12571223,-3.6937546e-08,-0.015103114,-0.052600164,0.0692847,-0.009469524,0.010632388,0.04025945,-0.06398539,0.013822327,0.04871982,-0.057130367,-0.030586885,0.08308883,0.02772432,0.05248038,0.029061211,0.059902582,-0.080784775,-0.011284867,-0.032071188,-0.08236361,-0.07173291,0.08342897,-0.10299802,0.06377553,-0.011361223,-0.013438152,-0.049843717,0.059080973,-0.06450989,0.026997004,-0.028694768,0.017482556,0.010643598,-0.014822673,-0.104278594,-0.018076142,-0.016094303,-0.09813115,-0.07885305,-0.008151489,0.029317748,0.036761742,-0.09393739,0.039984807,0.018361228,-0.052179787,0.03701809,0.03482111,-0.040773693,-0.011215579,0.10802235,0.027448906,0.05394842,-0.0811217,-0.05623983,-0.06507607,-0.06964931,-0.049652707,-0.048385084,0.042932555,0.037562303,0.040533178,0.17869882,-0.025954241 +1.13.11.94,The enzyme was isolated from the bacterium Caulobacter segnis and the fungus Thermothelomyces thermophilus. It is used as an economic option in lignin degradation since it does not require a cofactor.,384,1.0,-0.07085438,-0.030427592,-0.10540889,0.015455242,0.07231985,0.0771583,-0.04489369,0.043207474,0.027198689,0.0060382523,0.050846368,-0.042457327,-0.08405573,0.022855245,-0.07051992,0.014416568,-0.023525614,-0.02313047,-0.025355397,-0.0074792537,0.064850494,0.073293366,-0.02339924,0.0391952,0.042857286,-0.040701598,0.022173338,-0.01945785,0.0035089848,-0.03086346,0.010139816,0.03058993,0.07617132,-0.033287436,0.057856627,0.07912108,-0.037423424,-0.042889692,0.04718452,-0.00032533027,0.002142302,-0.028696211,-0.0041598035,-0.02552644,-0.11880976,0.04951034,0.014995709,-0.058103066,0.000725462,-0.03166118,0.008991016,-0.051305056,0.031616632,-0.017387109,0.012562192,0.022999944,0.0408977,0.018735228,-0.031132305,0.03590775,0.019894628,0.06935009,-0.024210475,0.037632994,-0.02995444,-0.055305663,0.039442964,-0.05632307,-0.005758657,-0.058117487,-0.026541738,-0.053948585,-0.009414786,-0.041387025,-0.0025369723,0.014745301,0.056093123,-0.07417202,0.06458422,-0.027918575,0.033247594,0.031584807,0.016409716,0.014520484,-0.032145236,-0.034854215,0.06267803,0.027617905,0.06584617,0.0013340503,0.05157359,0.03804206,-0.0034768546,-0.036969736,-0.02862746,0.06986775,0.04816963,0.054357048,0.08806604,-0.05152574,-0.02244938,0.03383106,0.034510173,-0.13660567,-0.09321629,0.017907081,-0.023269204,0.021259958,0.16112077,-0.00418336,0.014049576,0.04077339,0.006497902,-0.022934228,0.03818687,0.039616864,0.08422436,-0.04522337,-0.052878913,0.03576529,-0.02541919,-0.024503509,0.071832545,0.046837635,-0.07305974,0.09707924,-0.06051656,1.0932325e-33,0.015686493,-0.006264521,-0.09916059,-0.07124861,0.019776942,-0.056763124,-0.042639878,-0.012296984,-0.049484562,-0.07377839,0.018372862,-0.03406951,-0.041065272,0.029549394,-0.014779872,0.04141275,-0.025952421,-0.058250315,0.04203324,0.021313252,0.014026655,0.04842358,-0.030174168,0.031118326,0.0071489774,0.071644984,0.0886767,0.018279063,0.05309116,-0.015135234,0.102792546,-0.079762146,-0.1804596,0.00688386,0.112837404,0.01610005,-0.030997507,0.014738112,-0.05580388,0.011054307,0.07024377,0.058572177,0.052657153,-0.042126574,0.07160345,-0.0103787575,-0.088515125,0.10065409,0.03597721,0.017983163,0.024667434,0.020962507,0.030403798,-0.009361345,-0.041654743,0.036509495,-0.03305572,-0.0252289,0.0113405315,-0.026236616,0.05675461,0.07811569,-0.011495875,0.07346295,0.036723517,0.0023088483,-0.038290966,-0.03239711,0.009740957,-0.021900186,-0.07597134,-0.028441738,-0.04655222,-0.034686875,-0.0024427844,-0.041857395,-0.071046636,-0.022866849,0.004749842,-0.03445105,-0.019002894,-0.013325661,0.045920484,-0.04032972,-0.05629482,-0.03818574,-0.04854897,0.03335783,-0.06898683,-0.0051363762,-0.0030966515,-0.0761532,-0.002023859,0.049073923,-0.010440986,-3.2044872e-33,0.06255903,-0.052849744,0.040498484,-0.029225081,-0.033442907,0.04851246,0.01386027,-0.014315544,-0.044125196,-0.02259237,0.057074957,0.020567212,0.06933191,-0.015571738,0.07643161,0.071824394,-0.014374964,0.0281418,-0.046092194,-0.012983476,-0.018786995,0.072838634,-0.04959808,-0.02286666,-0.033641115,-0.0045648557,-0.052809652,0.022427382,0.032446455,0.0064786337,-0.01851201,0.02331669,-0.030911071,-0.0855251,-0.11012143,-0.04054337,-0.06648782,-0.0661184,0.042053383,-0.010861995,0.035836723,-0.0006507611,0.01736425,0.030340489,0.001178258,0.032493345,-0.11477662,-0.022985855,0.07816884,0.08979273,0.044840533,0.0027625903,-0.05987564,-0.0567607,-0.03638354,0.010592543,0.0009143529,0.028511059,-0.08033295,-0.037144437,-0.043363314,0.030925758,0.038922023,0.059327684,0.056127336,0.18566868,-0.005687751,0.045350153,0.029864078,-0.10509857,0.107680954,0.074370876,0.021152757,0.003882798,-0.008710502,-0.009380881,-0.053474914,0.010739661,0.01188277,0.023670586,0.06282091,-0.021576755,0.05757685,-0.02635694,0.02876969,-0.12929341,0.043558747,-0.0009447351,-0.02234334,-0.021325035,-0.03534198,-0.053390235,-0.031157522,0.058772113,0.029830106,-3.2937162e-08,-0.027506664,0.026975913,0.06770842,-0.074100554,-0.0043868134,-0.022853686,0.07252148,0.044977304,-0.003302148,0.03450069,-0.07988267,0.059945665,-0.05835597,0.14055315,0.03174343,-0.04573056,-0.055629246,0.0042617717,-0.027076177,-0.031910967,-0.04327642,-0.033647675,-0.048326757,0.06963084,-0.050966725,-0.0033979993,0.015825225,-0.009851463,0.068076074,-0.027789695,-0.06407994,0.10513861,-0.030947644,-0.032029487,-0.07681306,0.062468633,-0.047677033,-0.06505825,-0.0642689,0.038017195,0.06282533,-0.026198376,-0.015287455,0.0012592726,-0.017765913,-0.070292726,-0.011711618,-0.013223781,-0.0028614122,0.10068574,0.07491457,0.0054685436,-0.040342476,0.0104125105,-0.106934935,-0.05187326,0.023620753,-0.05058872,-0.0579386,-0.057448663,-0.006672507,-0.06575564,0.1581677,-0.0024024935 +1.14.14.186,A cytochrome P-450. The enzyme has been characterized from rice (Oryza sativa) and walnut (Juglans regia).,384,1.0,-0.08807536,-0.024985982,-0.06477631,-0.016660197,0.044544756,0.063720874,-0.049298506,0.026416037,-0.011811985,0.011954625,0.1147485,-0.00195673,-0.03550638,0.02122313,-0.06585154,0.03972673,0.01860062,-0.016895162,-0.047857653,-0.087680124,0.055338584,-0.006575874,0.057063486,0.0155628845,0.012697531,0.027647668,0.03704481,0.07286715,-0.014678652,-0.06337056,-0.07222252,-0.0023806999,0.034755886,-0.03748993,0.017594753,0.0427085,-0.06761185,-0.07374115,0.04927733,-0.0556125,0.054210454,-0.04241371,-0.014936798,-0.012510812,-0.025719063,-0.106931895,-0.04590263,-0.025081584,0.042659983,-0.043782115,-0.0049714255,-0.047435116,-0.04680036,0.0049427473,-0.036948863,-0.010278519,0.015281199,-0.061095815,-0.0344792,0.042138737,-0.029290788,0.017935038,-0.048505522,0.030358328,-0.028744206,0.03888472,-0.04657961,-0.052010845,0.036336258,-0.061480284,-0.05901022,-0.09215767,-0.016123667,0.05486165,-0.0642733,0.006298482,0.03636001,-0.040001843,0.0016834828,-0.020564713,-0.013285095,-7.071713e-05,-0.023324683,0.10918155,0.036695473,0.043647766,-0.062478043,0.11882516,-0.012856214,-0.06428186,0.010346238,0.023621516,-0.03270169,0.01005455,-0.061900478,0.08435479,0.019934507,-0.023640402,0.03257369,-0.025332889,0.086981565,0.059079308,-0.009525963,-0.12872954,-0.06948836,-0.0021158648,-0.015590788,0.03283438,0.047751985,-0.053152032,-0.024428103,-0.020014944,-0.019897884,0.008025885,-0.032539494,0.02152242,0.024124613,-0.010929199,0.018760582,0.011715943,0.0076522236,0.008926056,-0.015144467,0.017489886,0.007193255,0.09601377,-0.117806226,6.899552e-35,0.06702257,0.037306905,0.03571547,-0.01279143,0.0036367022,0.02574701,-0.031188453,-0.011137778,-0.04400279,-0.029646683,-0.12564288,-0.05080072,-0.03171876,-0.018039586,0.017517248,0.018875185,-0.056599315,0.026179872,0.03739845,0.009245663,-0.034388874,0.06005553,-0.09033365,-0.045982473,0.012118086,0.06245306,-0.025517138,-0.034520857,0.02221816,-0.00958136,0.017896561,-0.033705387,-0.09553573,-0.026059086,0.0045173666,-0.010342972,-0.022783265,-0.025797216,-0.049885146,0.047713164,-0.048194584,-0.001717866,0.042942476,-0.014455228,0.053460244,-0.040597785,-0.12706472,0.1118557,0.010900772,0.03622343,0.028214958,-0.022750057,0.066567875,0.073892795,-0.08574876,0.019135905,0.042557213,0.047203958,-0.024936827,0.05999986,0.09181829,0.07839039,-0.055881556,0.092589095,0.063540176,0.044776108,-0.09642795,-0.05106097,-0.02488161,0.14867562,-0.041961655,-0.035976037,0.03030838,0.013544899,0.040406995,-0.026546577,0.015881589,0.08595862,0.006366429,0.07216326,-0.028925104,-0.01695799,0.016277831,-0.006417844,-0.090004735,0.021003181,-0.040612783,-0.01756639,0.019080117,-0.0031599142,0.08525899,-0.058225363,-0.035455436,0.02879572,-0.06961455,-1.4986655e-33,0.07746738,-0.054991495,0.07554951,-0.03522353,-0.023840548,0.00052533206,0.008039557,-0.020984635,0.030457035,-0.0038333903,0.12359328,-0.036895975,0.048028998,-0.034220442,0.0061658355,0.077604264,0.0044830944,0.0963849,0.014921431,0.04624997,-0.047727,0.10177012,0.017432155,0.00012320207,0.05416371,-0.013739903,0.06936809,-0.010634684,-0.027315445,-0.022750612,-0.02759215,-0.013701406,-0.035831194,-0.061137054,0.027735809,-0.004591605,-0.022458112,-0.06377479,0.040086377,0.09832969,-0.06737605,0.12352499,0.056257322,0.08194712,-0.0039380128,0.051361363,-0.10065731,-0.038018767,-0.042276535,-0.04430065,0.0013576507,0.005861648,-0.00017713671,-0.0054396265,0.016692743,0.02335303,0.006350582,0.024264066,-0.022096435,-0.04931226,-0.01851375,-0.01652537,-0.010370026,0.07258741,0.02292285,0.107594825,-0.004228617,0.0024117148,-0.011931471,-0.0066770827,0.034768984,9.0966e-05,0.049191665,0.110984765,-0.050439604,0.018457737,-0.02880394,0.019529661,0.024329051,0.023806041,0.047852848,-0.023210462,-0.062175717,-0.016575644,-0.016292766,-0.06703346,-0.04770907,0.14654793,0.083825335,-0.0035299622,0.015941802,0.016581418,-0.090827905,0.03996839,0.08547144,-2.8488378e-08,0.026800694,-0.108405575,0.011820725,-0.02838586,-0.019235486,0.034846585,0.030584246,-0.03538766,0.07789241,-0.048061468,-0.009386702,0.07926685,-0.06199556,0.0058334535,-0.030938517,-0.0039029093,0.074814625,0.08723952,0.03122358,0.035623327,-0.083900675,-0.010261792,-0.040558837,0.012190385,0.030003004,-0.055884477,-0.018255647,0.02877261,0.0936672,0.005644645,-0.012001585,0.0069882646,-0.016118,-0.06304373,-0.018447375,0.11338561,-0.04865784,-0.067114495,-0.015188485,0.054207783,-0.0022974627,-0.10193341,-0.03701397,-0.048338685,0.017655266,-0.08442732,0.0066969036,0.021841671,0.004889122,-0.033589017,-0.037632797,-0.025963077,0.034777865,-0.10299594,-0.085916,0.0032021184,0.09044183,-0.039491642,-0.05957376,-0.065644346,0.072374314,0.049569096,0.1459631,0.016077373 +1.14.14.187,A heme-thiolate protein (P-450) isolated from the plant Alstonia scholaris (blackboard tree). 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+1.14.15.40,"The enzyme, characterized from the bacterium Corynebacterium cyclohexanicum, is a cytochrome P-450 enzyme that participates in the degradation pathway of cyclohexane-1-carboxylate. The initial source of the electrons is NADH, which transfers the electrons to a specific [2Fe-2S] ferredoxin via a dedicated EC 1.18.1.3, ferredoxin---NAD+ reductase.",384,0.99999994,-0.06812178,0.03194688,-0.093760945,0.04880745,0.019658992,0.03320079,-0.052691374,0.035361513,-0.015273046,-0.0446067,-0.03539999,-0.056458775,-0.022263903,0.014280733,-0.08026749,0.027877357,-0.0652911,-0.014959771,0.038852848,-0.034095112,-0.0020665186,0.034088567,0.0155252125,-0.017155644,0.029122282,0.016113425,-0.0012929095,0.02070291,-0.046971396,-0.04693622,-0.0040649385,0.015132552,0.029375471,0.010179026,0.029485513,0.12528327,-0.06611673,-0.06272215,0.058882758,-0.022386989,-0.021812716,0.05205168,-0.0156816,-0.03362435,-0.08061032,-0.009749451,0.017885607,0.008384708,0.059502006,-0.031848855,0.015957138,-0.052841116,-0.026513241,0.052429467,0.10005572,-0.014841829,-0.0012592513,-0.063751474,-0.022013463,-0.03700448,0.04762949,-0.012402657,-0.010980788,0.0805503,0.0065250876,-0.03320785,0.013263203,-0.07409149,-0.04371998,-0.0949163,-0.09482477,-0.06192955,-0.0064331796,-0.0058704126,-0.029968927,0.027698621,-0.031868506,-0.043260563,0.05015913,0.004638157,-0.0007714807,-0.026799558,-0.019177599,0.07368479,0.04585815,0.0055054794,0.021709854,-0.008445276,-0.05107749,0.0005979138,0.024197381,0.026674384,0.00759297,-0.016498288,-0.07778156,0.011986784,0.049087286,0.0037116099,0.022919573,0.017501498,0.0021394282,0.13249515,-0.007580339,-0.11688583,-0.063606136,-0.021128105,-0.005680201,0.12700348,0.048491433,0.0098772375,0.0056251115,-0.045149837,0.023095852,-0.03126556,-0.0052972124,0.09089391,0.017529638,0.011859863,-0.054021023,0.06442234,0.022729604,-0.022757312,-0.024331365,0.039814495,-0.029639333,-0.0017745416,-0.09862948,1.8390084e-33,0.08676095,0.020730292,-0.020236822,0.012051035,0.04311405,-0.0042149387,-0.06040133,0.00087738247,-0.003312385,-0.018129561,-0.09688576,-0.04206241,0.0748036,-0.07994078,-0.040978543,-0.017556615,-0.09639437,-0.024648499,0.041123886,0.043978393,0.043282088,0.02250216,-0.0006768616,0.04637425,0.035610065,0.0789416,-0.0148750385,0.04041013,-0.014355288,-0.0050443313,0.009395628,-0.09502766,-0.14483891,-0.041815333,0.04833831,-0.06565793,0.01362583,-0.027801014,-0.016554328,0.060865324,-0.049735863,-0.014408892,-0.00029276367,-0.06740018,0.083716445,-0.06790093,-0.053758215,0.09731944,0.023228684,0.09101252,0.04010723,-0.117051244,0.0965662,-0.02745682,-0.07136643,0.059791666,0.0011113496,0.018776007,0.0152030345,0.08915789,0.08262556,0.07225107,-0.033268362,0.023849243,-0.010993548,0.0722014,-0.043240808,-0.03632322,-0.03939486,0.10852152,-0.066968866,0.02940832,0.07769763,-0.020702543,0.08609599,0.009281731,-0.07864496,-0.048265252,0.087303475,0.0045235725,-0.005987558,-0.042585704,-0.010128232,-0.056943253,-0.016262826,-0.037069604,-0.04787523,-0.04631017,-0.04894329,0.057768136,0.08039476,-0.08125018,-0.014321232,-0.016457906,-0.009882902,-3.0804114e-33,0.1084669,-0.06425721,0.044385612,-0.120587505,0.0080703925,0.055586137,0.026650762,-0.018183408,-0.0033849834,0.0075264275,0.072660856,0.048207723,0.046142206,0.013804076,0.007063953,-0.0039276015,-0.0063614394,0.04118897,0.005514085,0.013554261,-0.0027862226,0.042335857,0.050092835,-0.05074226,0.05772093,-0.001213614,-0.037573025,0.06096325,0.12617826,0.0030025241,-0.03492347,0.003945839,-0.027618,-0.008587091,-0.061710775,0.108639345,-0.040264092,-0.020350222,0.060252603,0.015124602,-0.0016299938,0.028502341,-0.06042233,0.08207603,0.06966966,0.044833593,-0.11963251,0.008347821,0.029996527,-0.044745244,-0.022893872,0.035088733,-0.025748827,0.0084808385,-0.026837977,0.07829976,0.032179803,0.025953611,0.013279044,0.039121296,-0.035482913,-0.090334326,0.054648466,0.10339045,-0.0006722131,0.037628982,-0.03594236,0.07487148,0.04117802,0.021003436,0.0968342,0.0036870777,0.0069292695,0.018558575,-0.06701518,-0.011372205,0.014961096,0.0054892134,-0.0052711135,-0.0330864,0.012346416,0.017222708,-0.036561515,-0.02384848,0.011743159,-0.12849487,-0.0046041617,0.059109934,0.0069435546,-0.04255796,-0.05042834,0.048061475,-0.0066018854,0.010037876,-0.0033631776,-4.138792e-08,-0.02649191,-0.04501859,0.048954237,-0.034113508,0.12597336,0.051680665,0.031648967,-0.013185372,0.034632266,-0.104565315,0.024566343,0.12728995,-0.0002423506,-0.0061699,0.06847249,0.07302255,-0.06543831,-0.014862186,0.011594401,0.014578047,-0.039707106,-0.064209126,-0.1212358,0.07577209,-0.02252359,-0.0919178,0.043460183,0.043173727,-0.031557847,-0.04573271,-0.04444075,0.036363058,-0.00325578,-0.014953591,-0.07770151,0.006392566,-0.090520985,-0.004961731,-0.046821624,0.028180983,-0.023507893,-0.013706552,-0.07226574,-0.029120805,0.005826822,0.027475134,0.025523774,0.010552786,-0.00092354335,-0.01981716,0.043505326,-0.035789337,-0.039389182,-0.047035407,-0.06413458,0.060012776,-0.010291603,-0.02875618,-0.00127037,-0.03227805,-0.001684214,0.038526308,0.19024445,-0.037464052 +1.14.19.80,"A cytochrome P-450 (heme-thiolate) enzyme characterized from the plant Catharanthus roseus (Madagascar periwinkle), that participates in the biosynthesis of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine. The enzyme generates a nine-carbon ring that contains a nitrogen atom. The direct product of the enzyme, 3,17-didehydrostemmadenine, is unstable, and in the absence of other enzymes becomes akuammicine non-enzymically. However, in the presence of two dehydrogenases it is converted to stemmadenine via 17-dehydrostemmadenine.",384,0.99999994,-0.023187542,0.003996352,-0.14626242,-0.06699465,0.021531403,0.03490739,-0.085257575,0.0854085,0.0033182462,0.019297238,-0.0245914,-0.013270306,-0.023359252,-0.026312603,-0.058199883,0.044484276,-0.068621956,-0.0024590292,-0.012143522,-0.06689671,0.008156109,0.076494485,0.034182537,0.014825634,0.06263649,-0.00413913,-0.015855286,0.036615707,-0.005500082,-0.045668505,0.014672701,0.017160743,0.009004104,-0.022711053,-0.012620281,0.068233795,-0.10407339,0.024053523,0.028408365,0.058329243,0.06531799,-0.020999035,-0.07942515,0.027255267,-0.029052991,-0.054533206,-0.026925502,0.0441775,0.010452841,-0.043840464,-0.048687913,-0.053248595,-0.015762307,-0.003565081,-0.013800844,-0.08090161,-0.003156771,0.01826616,-0.02994498,0.042008698,0.053033255,0.03104893,-0.03449766,-0.008647254,-0.0036421383,-0.046000093,0.011713103,-0.05702621,0.040020987,-0.0930051,0.0064234165,-0.07457795,-0.05177041,-0.04323464,-0.097237304,0.05737594,0.0026922408,0.025996463,-0.009027966,-0.017543923,0.036884237,0.024440136,-0.019956695,0.10145322,0.04902231,0.012700311,-0.007822233,0.08807778,-0.024937676,-0.005996651,-0.008449292,0.033244316,0.012511147,0.0062405183,-0.09921938,0.079867624,0.026439024,-0.023774821,-0.014071059,-0.016734274,0.013830312,0.048967425,-0.09103206,-0.04242716,-0.08684491,-0.0011571759,-0.052677438,0.03353687,0.02932374,-0.015464982,-0.012465206,-0.026264038,0.0076747388,0.02015117,0.0006294272,0.07034947,0.034082662,-0.045282625,-0.0046822946,-0.0009719036,-0.02568409,-0.010792695,0.07014799,0.025184048,-0.015607738,-0.009338329,-0.06597713,3.083492e-33,0.109470546,0.023662152,-0.0099886935,0.03331819,0.04890373,0.0035919428,-0.12194216,0.061370958,-0.045182593,-0.0058335583,-0.10647435,-0.08828022,0.02206223,-0.018362347,0.0048699407,-0.061155185,-0.0053140796,-0.018202027,0.036379036,0.019051673,-0.027961582,0.020218033,-0.13401204,0.023630653,-0.008482723,0.089675665,0.0059783193,0.036550064,0.038963813,-0.014704281,-0.04250994,-0.12760113,-0.07038705,-0.028621867,-0.013349664,-0.058026794,-0.061672866,0.03168672,-0.011266656,0.070013896,-0.017765276,0.011703088,0.054158673,-0.042817894,0.114230916,0.00065969623,-0.077453464,0.08784259,0.06187181,0.07988086,0.019852325,-0.01919639,0.17765933,0.044197433,-0.0701753,0.040982116,0.018191345,0.03244765,0.05510758,0.06571358,0.02975168,0.02143774,-0.022728369,0.07278827,-0.0040713046,0.026575044,-0.03366656,-0.033467818,0.004036763,0.086568564,-0.055228423,0.02337064,0.041830346,0.0036480073,0.045342818,-0.0074805715,-0.014931552,0.09428208,0.037269853,-0.0015445827,0.0030609465,-0.0043043154,-0.013012687,-0.01603291,0.0008182381,0.009320936,-0.016909003,-0.067802034,0.008354628,0.05819182,0.008996423,-0.09383545,-0.03139561,-0.030170191,0.06338692,-2.8516966e-33,0.08877278,-0.057395816,0.0036001436,-0.061833143,-0.01261882,0.07144242,-0.030218592,0.032615487,-0.03290348,0.0019044768,0.08809435,-0.010369029,0.0155455405,0.009195963,-0.026934577,-0.039752778,0.03423159,0.12231006,-0.012531133,0.0049082018,-0.04156255,0.07213581,-0.081687525,0.01973137,0.044754826,0.012594709,0.03640367,-0.01381811,0.037035227,0.03814932,0.0014300382,-0.007503933,-0.11526132,-0.010524566,-0.054108042,0.07332389,0.0025405462,0.0017528594,-0.008506516,0.06522329,-0.031305097,0.06639116,0.013581916,0.07128073,0.043652423,0.032180425,-0.10243836,0.022250446,0.00073793676,-0.04312107,0.07486754,0.022311948,0.028213628,0.03679558,0.039274443,-0.017379096,0.07655604,0.012250929,-0.010354351,-0.046548996,-0.0058135074,-0.098550156,-0.018211171,-0.0010964813,-0.0297342,0.040657084,-0.043074556,0.05894388,0.06637268,0.020204049,0.037810214,0.0052272864,0.0019602575,0.067536645,-0.036371637,0.012466113,0.02917905,-0.055751104,0.02769319,-0.03991348,0.019497154,-0.02995605,-0.025492271,-0.08755119,-0.02835042,-0.116377294,0.03397274,0.09749811,0.015478907,0.0068653966,-0.002759823,0.059860166,-0.074958645,0.06478994,0.107989274,-4.1513545e-08,0.05097686,-0.04398081,-0.015292526,0.0020487842,0.0030168567,-0.040634062,0.05420878,-0.028598279,0.043856688,-0.056088235,-0.0011894049,0.065861374,-0.041837797,0.034683295,0.06408869,-0.0051154546,0.0826707,0.018982453,0.016692251,0.03652942,-0.07192865,0.04380908,-0.0879741,-0.054654915,-0.002837289,-0.107098445,0.018340072,0.0061889673,0.062280662,0.023738764,0.043872215,0.05032327,-0.0014626083,-0.048300195,-0.07803049,0.0053722323,-0.030832551,-0.028385343,0.025265766,-0.056108303,0.0009196046,-0.07086912,-0.08595575,0.0075432057,-0.03251695,-0.02686387,0.032990087,0.02415166,-0.0080102235,-0.028087359,0.0027679843,0.04997265,0.09064971,-0.13146825,-0.09827185,0.047045585,0.022617107,-0.058276147,-0.017437927,-0.11010642,0.014118403,-0.011466667,0.23048386,-0.012873264 +1.14.19.81,"A heme-thiolate protein (P-450). The enzyme, characterized from the plants Rauwolfia serpentina (Indian snakeroot) and Gelsemium sempervirens (yellow jessamine), is involved in the biosynthesis of monoterpenoid indole alkaloids of the sarpagan, ajmalan and alstophyllan classes.",384,0.99999994,-0.03203687,0.0016803491,-0.064318515,-0.0027258755,0.010498862,0.06514681,-0.009206321,0.07919869,0.049507998,0.00035184322,-0.0027891009,-0.04442349,-0.030982343,-0.006974307,-0.043488793,0.044833977,-0.035623137,0.048397195,0.001273182,-0.10663139,0.025052568,0.100665286,0.049367685,0.0068828086,-0.00032042552,0.04226026,0.018924616,0.0011391352,-0.0058946763,-0.043109972,-0.014227811,-0.020484343,0.051111747,-0.037902445,0.0024548897,0.08222996,-0.09621064,-0.007620009,0.021223182,0.020017225,0.08469938,-0.05546488,-0.04009107,-0.010661729,-0.06612626,-0.050559048,-0.039321434,0.025780417,0.017884132,-0.01425769,0.035284642,-0.054056242,-0.07958973,0.014079253,-0.009702007,-0.0748835,-0.004406598,0.015483194,-0.005013372,0.010046289,0.025680933,0.08367869,-0.0065837475,0.02397294,-0.013098496,-0.08848763,-0.016476495,0.02840331,0.028324267,-0.074519575,0.008345289,-0.06030256,-0.04633174,0.016168986,-0.068188295,0.09726071,0.011159705,0.02454027,-0.04300684,-0.06156159,0.06152632,0.06481965,0.0968839,0.092119224,0.01973911,0.073915526,0.022270065,0.059498146,0.02942983,-0.046159405,0.0795577,0.020329844,-0.01988055,-0.03857813,-0.07438396,0.04240611,0.05886023,0.018301103,-0.051812626,0.02218247,0.062113732,-0.012186314,-0.04783965,-0.095868856,-0.05055047,-0.012274355,-0.08166129,-0.04170598,0.068481244,-0.042982265,-0.000317283,-0.049553394,0.007911966,0.011763935,0.03520263,0.11440421,-0.03247842,-0.006269869,0.0006089274,-0.042273562,-0.06727653,-0.03257396,0.025773967,0.034729354,-0.021577397,-0.0075656394,-0.11080637,4.4125802e-33,0.07857075,0.02492044,0.0024886082,-0.038390856,-0.0003108388,-0.06285271,-0.08003468,0.036963664,-0.08007834,-0.023387073,-0.0914968,-0.05349876,0.017924212,-0.015006615,0.028890869,-0.0326704,-0.10147541,0.0511848,0.056759167,-0.053837065,-0.062476672,0.037462953,-0.06409286,0.07166216,-0.016316036,0.05165754,0.014630924,-0.04042856,0.047689047,-0.012247668,-0.03856581,-0.07459448,-0.0091834655,-0.028971456,-0.05212079,-0.030017804,-0.031098206,-0.005929794,-0.11923696,0.026762972,0.002108176,0.039382096,0.020857982,-0.0053765345,0.047027316,-0.049097665,-0.094962075,0.049869485,0.024561986,0.08854754,-0.009464389,-0.00812731,0.16029842,0.03171171,-0.081366174,0.042321112,0.042663407,0.019271439,0.025381403,0.0413582,0.07113436,-0.01701048,-0.04408117,-0.016163474,0.013436656,0.050617263,-0.042664643,-0.07123029,0.04394585,0.09942706,-0.039607007,0.004130258,0.022874279,-0.01688917,0.052930463,-0.01566817,-0.0073211403,0.03556818,-0.044015363,0.024483442,-0.022162873,-0.008442428,-0.018938573,-0.03788069,-0.017159922,-0.040962055,0.039547063,-0.02378175,0.008244579,0.009886415,0.10781465,-0.016504807,-0.08157126,0.046198867,-0.033372473,-3.0858637e-33,0.052926235,-0.07227487,0.04836271,-0.037414383,-0.055384796,0.04988509,0.018306658,0.010663243,-0.036165,-0.0048056967,0.10384512,0.007284207,0.053928774,0.019566134,0.013993726,-0.057425227,0.017307855,0.087187506,0.0017033973,0.078947045,-0.07459202,0.08806283,-0.017401021,0.017770465,0.021602588,0.024508797,0.009669879,0.0013279644,-0.02642306,0.043906227,0.022027321,0.014992221,-0.08047623,-0.0040396303,-0.07665939,0.024501756,0.019991942,0.01747572,2.5136553e-05,0.07673326,-0.0418118,0.09428327,0.0055453544,0.08131431,0.056791816,0.0494284,-0.065383546,0.05909313,-0.024339056,-0.059409562,0.03466505,-0.004019048,0.058009796,0.01194543,0.0049426537,-0.026011618,-0.002665887,0.03826346,-0.030062525,-0.034723382,-0.015271201,-0.05312959,0.008115053,0.051206123,0.0024680768,0.10607746,-0.03976433,0.02312254,0.06594067,-0.051720854,0.04709826,0.03927332,0.049840905,0.082747065,0.055916708,-0.05937883,0.029768711,-0.04904761,-0.011226942,-0.023923608,-0.03241912,0.06052274,-0.006077654,-0.1060508,-0.020259049,-0.0153404595,-0.0037019954,0.12828916,0.05638667,0.0021583103,0.011309355,0.06676574,-0.068212956,0.122770645,0.08161863,-4.1913772e-08,-0.022361143,-0.09437042,-0.008886,0.003960585,0.025930803,0.011597366,0.07400263,-0.036580835,0.052940764,0.008890083,0.007085482,0.060513515,-0.05164309,0.025706144,0.041169625,0.00874475,0.0361858,0.07202458,-0.0044188276,-0.02309443,-0.006552943,0.04557402,-0.0013728273,-0.0054096337,0.0161422,-0.08899292,-0.041340176,-0.026302189,0.034701873,-0.019509,0.012235485,0.062057193,-0.05016438,-0.044822466,-0.021343479,0.051717706,-0.048124943,0.010181717,0.010456398,-0.0036315706,-0.0008570335,-0.07940257,-0.066637814,-0.0446402,0.002579389,-0.006061942,0.025786785,0.02826011,0.0033374357,-0.08349175,-0.015315851,-0.00034908633,0.037390884,-0.1417599,-0.14425479,-0.06775658,-0.02681524,-0.01301903,-0.062122438,-0.12153157,-0.016481368,-0.04133919,0.22520918,-0.018334549 +1.21.3.11,"The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs. The enzyme is similar to berberine bridge enzymes such as EC 1.21.3.3, reticuline oxidase, and requires an FAD cofactor.",384,1.0,-0.03787623,-0.007820545,-0.15827106,-0.018725121,-0.0041859006,0.083172955,-0.06278388,0.061911467,0.09088463,-0.006969557,-0.012129125,0.02519302,0.0078523485,-0.027854988,-0.11711593,0.08120349,-0.07376424,0.046136744,-0.0043780305,-0.044597536,-0.015343006,0.04533905,0.049307134,0.03129607,0.0028488936,-0.0067729815,-0.04704651,0.012197166,-0.004721693,-0.012563366,0.07657908,0.05756439,-0.022923369,-0.031394545,-0.06490887,0.06279538,-0.038610898,0.0006816333,0.009773975,0.08045054,0.039896246,-0.011216941,-0.018079951,-0.0007437165,0.038359616,-0.07766746,0.000324015,0.011636041,0.061633628,-0.013036921,-0.006307563,-0.049735013,-0.06429229,-0.021827865,-0.041040573,-0.085122965,0.061326507,0.05907901,0.013227973,0.064994246,0.0733457,-0.0009151924,0.029009793,0.03505433,-0.035341315,-0.049871307,-0.077029385,-0.044055477,0.02124557,-0.07331171,-0.015509772,-0.098301284,-0.06189568,-0.026610972,-0.028408166,0.012816218,-0.015019175,-0.007285289,-0.010455762,-0.017301248,-0.009517142,0.015580069,0.032046277,0.11025039,0.08005386,0.044265576,0.046875406,0.023947122,0.05526895,-0.0108392285,0.06963616,-0.0034702716,-0.040074024,0.013812549,-0.097980194,0.0077641965,0.017897798,0.0031129043,-0.05299995,-0.00943464,-0.0022519066,-0.0050034225,-0.097918436,-0.07089862,-0.0915633,0.043737233,-0.0010608113,0.055315483,-0.00032322478,-0.022135371,0.008662319,-0.024179848,-0.016810466,0.012905073,-0.009914815,0.09800864,0.06380948,-0.07052789,0.01694427,0.021610951,-0.060506977,-0.011693932,0.062492967,0.022973314,0.008165575,-0.00705355,-0.038634527,2.3975917e-33,0.044676892,0.03308327,-0.039425388,-0.04368972,0.03976097,-0.013888131,-0.13697733,0.034401484,-0.027190847,-0.06563218,-0.07828554,0.03912721,0.023866756,0.02298998,-0.043365005,-0.028969679,-0.0041050785,-0.03769408,0.01860887,-0.076998696,0.030255409,-0.0051976545,-0.04755259,0.024791922,0.012177876,0.056373917,0.03402716,0.022512227,0.026733102,-0.011072103,-0.005259337,-0.13411422,-0.06946081,-0.022920318,-0.0682934,0.02579603,-0.05039571,0.003513039,-0.035486344,0.09639591,0.008036034,0.02512965,0.03144187,-0.021646142,0.13467874,-0.0475543,-0.03991469,0.16105364,0.047386777,0.0654521,0.0094812615,0.03352245,0.10050271,0.08543106,-0.10648275,0.0150891235,-0.036514554,0.035340723,0.026543692,0.04923297,0.021102646,0.016538598,-0.029174548,0.05419524,0.006784306,0.020617953,-0.000724844,-0.041562505,0.055092644,0.06411057,-0.0794066,0.015371951,0.031873573,0.039571717,0.04297697,-0.048501547,0.006555433,0.055238612,0.042980157,0.05354087,-0.05924097,-0.051185165,0.021612946,0.023856618,-0.0679424,-0.0029453668,-0.034326036,-0.04824503,-0.06463332,0.04610697,0.009307646,0.010082839,-0.07541948,0.03950246,0.06691878,-2.5933734e-33,0.074263796,-0.06224881,0.07730509,-0.068721846,-0.022954728,0.0535057,-0.0012962761,-0.013194341,0.040728875,-0.014381897,0.041103303,-0.009077444,0.08429306,-0.0065069087,-0.0041697253,-0.059529617,-0.0007929404,0.074354425,-0.021086693,-0.0051643145,-0.10845041,0.14466238,-0.033428833,0.035947084,-0.0031902958,-0.035219036,-0.0068871235,-0.03387988,0.0042790673,0.076706424,0.053187534,-0.009465955,-0.075618,-0.019929312,-0.053519733,0.08995859,-0.03366381,0.022479767,-0.019455513,0.05529034,0.051160384,0.006597622,-0.012782789,0.04722729,0.04642828,0.019165048,-0.1454728,0.10829993,-0.020561216,-0.03301792,0.0286214,0.041783944,0.04279985,0.004002642,0.091938615,-0.0055309986,-0.005961892,-0.036226023,-0.033922844,-2.6712335e-06,0.00012519276,-0.06706428,0.00796144,-0.02637925,0.004433824,0.03726104,-0.031875674,0.011244581,0.07061618,0.014316744,0.09565358,0.0274225,-0.0065497058,0.07476749,-0.049929243,0.012581693,0.016167874,-0.035972163,0.03475951,-0.03357316,-0.033273764,-0.002369541,0.02794237,-0.077736124,-0.039192006,-0.012623839,-0.025436198,0.05541875,0.044698723,0.0098514585,-0.009862195,-0.014689217,-0.106995285,-0.011567719,0.053488143,-3.9025643e-08,0.048539545,-0.030068997,0.063403696,0.006889344,-0.043986414,0.003375858,0.04415032,-0.0045225704,-0.032623794,-0.019655334,0.013250375,0.09969761,-0.0274015,0.020383226,0.024265602,0.029512784,0.08112697,0.020917991,-0.015879445,0.032265726,-0.060314216,0.0020075464,-0.05492882,-0.04464683,-0.02139295,-0.12601122,-0.002631512,0.00015831235,-0.012899038,-0.0136038,0.06495916,-0.013009633,0.026275408,-0.037792508,-0.056528382,0.08185968,0.0015846714,-0.011769583,0.022220662,0.010862832,-0.008690291,-0.0643066,0.0011537239,-0.050644957,-0.06792998,-0.02364793,0.032283984,0.022472993,-0.023045808,-0.039785914,0.04453428,-0.0030754306,0.067777894,-0.11326524,-0.112506054,0.029752705,-0.015288738,-0.09053164,0.000105071784,-0.11748324,0.012326464,-0.03188178,0.21248256,-0.034893572 +1.97.1.13,"An oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters, isolated the hyperthermophilic archaeon Pyrococcus furiosus. In that organism the enzyme is heterodimeric, comprising a catalytic subunit that contains the active site tungsto-bispyranopterin cofactor and a [4Fe-4S] cluster and an electron-transfer subunit that contains four additional [4Fe-4S] clusters. The activity involves two steps: an oxidative desulfonation reaction, followed by the activation of a second water molecule and oxidation of the resulting aldehyde (cf. EC 1.2.7.5, aldehyde ferredoxin oxidoreductase).",384,1.0,-0.0032148114,-0.041991547,-0.107009664,0.043254357,0.1012981,0.014990397,-0.05912083,0.015748054,0.0085017625,-0.068989396,0.040696464,-0.057707567,-0.08733913,0.058184132,-0.09109285,0.07437946,-0.099241756,-0.029537683,0.011290248,0.01550821,0.033226017,0.022412375,0.049722403,-0.009972603,-0.03728528,0.05595401,0.017681845,0.022018414,-0.038500518,-0.0017408213,-0.024272444,-0.07242874,0.067456044,-0.049897708,0.06455507,0.095673695,0.0056771813,-0.025568767,0.037794657,-0.00239988,0.0100161955,-0.0071797133,-0.022014305,-0.0290412,-0.043118868,-0.009120435,0.029344039,0.025449092,-0.025608443,0.016466623,-0.024351228,-0.06777632,-0.064909406,0.0864888,-0.024878195,-0.0031288445,-0.045195557,-0.048376895,0.036275055,-0.09847314,0.09712655,-0.0047662677,0.056293715,0.0073683923,0.030280182,-0.030586122,0.022502381,-0.019427579,0.0278863,-0.101606,-0.08195829,0.037116364,-0.0057393103,0.04075329,-0.024994282,0.06449488,-0.028436532,-0.055375494,0.072228976,-0.007281008,0.042297546,-0.0016365084,-0.003129621,0.10016306,0.06491431,-0.06336946,0.048571993,-0.04268021,0.0031068348,-0.07160853,0.025274565,-0.024532793,-0.021032952,-0.031407505,-0.07549463,-0.016449748,0.09253299,0.09637438,-0.0080993455,0.024127593,-0.047895506,0.0064523565,-0.019271905,-0.1015397,-0.0502325,-0.037621472,-0.026837744,0.09992077,0.12430026,0.015167114,-0.057223808,0.013593553,-0.015444679,0.013552068,0.01770105,0.0528915,0.0748833,-0.037674244,-0.08355144,0.051573243,0.06167977,0.007914336,0.06796417,0.029469363,-0.014295232,-0.017910726,-0.09237116,2.9683444e-33,0.07997631,0.017960638,-0.0072756633,-0.01925627,0.094724834,-0.06480563,-0.08974949,-0.029387953,-0.060717985,0.018230647,-0.09571182,-0.011968137,0.08871675,-0.023370463,0.00358305,-0.023661984,-0.018041017,0.01243355,0.0829004,-0.02660433,0.04392422,0.08124,-0.021472039,0.011829676,-0.0049701473,0.03918765,0.0010855299,0.005629335,0.0025346726,-0.003026864,0.04680017,-0.13007185,-0.13184175,-0.05053998,0.03885567,-0.018927725,-0.018086566,-0.10052814,-0.0058718873,-0.08603547,-0.05268367,-0.014370893,0.0060906517,-0.05706425,0.10066558,-0.041792445,-0.02833049,0.08927362,0.00057522574,0.052922636,-0.017153965,-0.056609564,0.06728063,0.011051665,-0.075305164,-0.0301826,-0.0025254742,-0.014856886,0.048612267,0.05433421,0.06184504,0.019308694,-0.026948359,0.004441386,-0.012374094,-0.034740616,-0.0008156253,0.029508179,0.04158979,0.07569547,-0.048017386,0.020437527,-0.022290086,0.0019474297,-0.074870296,-0.046654608,-0.011490558,-0.036379803,0.01683327,-0.03219581,-0.030585622,0.0028982062,0.03754538,-0.037166245,-0.028509187,0.00971042,-0.09096742,-0.030041909,-0.049459726,0.02846446,0.006783455,0.004696649,-0.060635623,-0.038948733,-0.019923426,-3.4498533e-33,0.11864572,-0.091666125,0.029385287,-0.09510307,-0.038401652,0.08753685,0.008349086,0.056204256,-0.008845734,-0.044433467,0.087188,-0.011057331,0.0199452,-0.07196266,0.074404314,0.061493564,0.016016884,0.047457743,0.10266796,0.0004485173,0.08369095,0.040736664,-0.071948595,0.032971624,0.01364155,0.010605379,0.012591061,0.013453585,0.090075694,0.034804177,-0.015527575,0.01235568,-0.020572113,-0.07008333,-0.0047031776,0.034197357,-0.034995575,0.005457318,0.03126302,0.028933097,0.06294099,-0.030073477,-0.039229367,0.07872717,0.059068806,0.057984363,-0.077267244,0.008475714,0.012955913,-0.0026867236,0.054458886,-0.03834695,-0.037318025,-0.0080206655,0.036705,0.0706749,-0.032928843,-0.024326699,-0.063652135,0.024748417,0.0040595755,-0.10740878,0.005488409,0.046969745,-0.046236385,0.062007736,-0.030724851,-0.007015775,0.034857742,-0.005203971,0.04800529,0.030370323,-0.027925495,-0.015806695,-0.017624052,-0.048894342,0.041701328,0.02571565,0.018083654,0.021958383,0.009223048,0.046504404,0.08542427,-0.10089095,0.044218738,-0.052125003,0.036475234,0.09980764,-0.0404471,0.012440643,0.00245435,-0.029245013,-0.012451273,-0.010703156,0.008952668,-4.2230482e-08,-0.006353769,-0.027467329,0.07513314,-0.026027288,-0.017119844,0.03204144,0.073643476,-0.006102791,-0.05177822,-0.032265488,0.090337045,0.06697689,-0.014686358,-0.03552839,0.03780172,0.03119748,-0.04464316,0.020427082,-0.029308032,0.0035466498,-0.012185592,-0.011489933,-0.055308204,0.0718129,0.039877698,-0.044053495,0.0371858,-0.006986596,-0.022905622,-0.06382894,0.005458357,0.04846194,-0.0030874014,0.0017457383,-0.07377582,0.014656064,-0.10005542,0.014116418,-0.08148576,-0.018907635,-0.020070689,0.011788601,-0.043600712,0.007890169,0.057418514,0.0494212,-0.045408014,0.02986813,-0.0019327931,0.025495183,0.11743964,0.007564714,0.055107214,-0.028887313,-0.1636541,0.07675726,0.032966916,-0.074995555,-0.08915509,-0.029382285,0.12422648,-0.02987305,0.13080893,0.0007337822 +1.97.1.14,"The enzyme, characterized from the bacterium Mesobacillus selenatarsenatis, is a membrane anchored type I molybdoenzyme. The enzyme is a complex comprising three heterologous subunits that contains a guanylyl molybdenum cofactor and multiple iron-sulfur clusters. The enzyme receives electrons directly from the membrane quinol pool and reduces selenate to selenite.",384,0.99999994,-0.03292112,-0.03288725,-0.049477562,0.041711524,0.045788262,-0.07661767,0.031396355,0.032077156,0.03411657,-0.091389716,-0.03733281,-0.08329108,0.021456528,0.046368156,-0.089310676,0.03348328,0.000331058,-0.058260612,0.023816431,0.018714063,0.05221137,-0.008845704,-0.061345052,-0.083890334,-0.008035609,0.0077254595,0.013605252,-0.045917694,0.0071579907,-0.09089604,-0.014645215,-0.058871765,0.046219654,-0.007059735,0.07174419,0.09608565,-0.030682588,-0.040666025,0.01599587,0.011219416,-0.010814093,0.041303925,-0.01033429,-0.013844876,-0.061832655,-0.026506485,-0.0046681403,-0.009481858,0.0068785544,-0.011883553,-0.043469004,-0.06548066,-0.09637798,0.07023361,0.030469947,-0.035932686,-0.010171188,0.06646111,0.0057853474,0.018056836,0.132912,0.03495539,0.081224136,-0.006687959,0.0090714805,-0.010451456,0.03595303,-0.02619147,0.025525289,-0.08618977,-0.030512447,-0.028943906,-0.009347697,-0.007079579,0.009287865,-0.013053962,0.029972931,-0.0042561395,0.06862255,-0.024002308,-0.052025154,-0.057700995,0.009103373,0.07336659,0.02380106,0.048001837,0.026084566,-0.011758167,0.010628674,0.052513115,0.00051995984,-0.04454665,-0.03299417,-0.047094565,-0.06180401,0.043662507,0.009922109,0.019413015,0.013742633,0.029965311,0.013850259,0.067674756,0.040275954,-0.07994341,-0.09380841,-0.025178237,0.0058373003,0.08266072,0.021558143,-0.0026262477,-0.0011940687,0.026723117,0.06030264,0.006253279,-0.016959526,0.029710716,0.07292986,0.060380153,0.022019302,0.087649375,0.06196383,0.013935137,-0.0096810255,-0.0024287894,-0.014871666,0.076266296,-0.084691614,6.157446e-33,0.027837234,0.033202056,-0.035312932,-0.015978264,-0.053024903,-0.041427173,-0.06158063,0.034863073,-0.12615897,-0.018709902,-0.056481365,-0.10375538,0.02001892,0.02430779,0.01635412,-0.0006559364,-0.07420746,-0.04895222,0.05813711,-0.0038226037,0.014852573,0.051070772,-0.04991203,-0.013002287,0.076134115,0.024345549,-0.015439499,0.039660934,0.013957043,0.0124654565,0.07105029,-0.1153294,-0.09510077,-0.0016674999,0.05777864,0.04201061,0.043370456,-0.01872776,0.004475255,-0.044661567,-0.03480506,0.057760894,0.010855314,-0.038365737,0.07048849,-0.05069712,-0.033250183,0.12790178,0.051863156,-0.043171905,-0.020648522,-0.05436115,0.09182892,-0.08608148,-0.05437761,0.067217976,0.006543844,0.049964186,0.047529418,0.066317186,0.09511161,0.030292768,-0.04347302,0.063191935,0.083091766,0.033327024,-0.02229646,-0.027187275,0.0933116,0.0788063,-0.118518986,0.013900082,0.03313817,0.04330149,-0.042885687,-0.09034439,0.032796618,-0.06739195,0.037931997,0.04021159,0.019711176,-0.05221519,0.0875145,-0.11689832,-0.039131768,-0.0069135423,-0.06403467,-0.03265022,-0.024799239,0.03973498,0.028737923,-0.027627574,-0.08250565,0.015280394,-0.10609607,-5.682059e-33,0.0495159,-0.08413361,0.08367073,-0.06697689,-0.06549242,0.06657059,-0.04645371,0.006598249,-0.042953826,-0.006582013,0.051414628,-0.0010330951,0.038471185,-0.05409995,-0.034123644,0.052270707,-0.04119392,-0.032996144,0.04126826,-0.032964908,-0.04840089,0.06835073,0.043043308,-0.02733812,-0.0398834,0.04024639,-0.054100223,0.03719845,0.023680072,0.06693716,-0.0063572046,-0.045565277,-0.002873796,-0.07918561,-0.09219419,0.023856875,-0.055943564,-0.033483095,0.08374863,-0.0034186188,-0.007243995,0.05681209,0.009488084,0.010484687,0.00075049564,0.097723685,-0.06523961,0.024752341,0.02413126,-0.03935386,-0.05281264,-0.03367879,-0.044551898,0.005475354,0.007641631,0.023367312,0.012965759,-0.012406369,-0.0618901,-0.042132627,-0.04848757,-0.05267097,0.04780664,0.01586479,0.056750134,0.073927514,-0.0109752575,-0.02403961,0.005890925,-0.034213148,0.05635472,0.0033073286,-0.041991454,-0.015901115,-0.018919421,-0.037245993,-0.065758996,0.052332435,-0.03327557,-0.04100269,0.06287408,0.05613317,-0.010974074,-0.06620214,0.07585991,-0.037400004,-0.022126922,0.17019786,0.09237922,0.04121832,-0.020341745,0.03643777,-0.068220176,-0.0043985695,0.06258426,-4.2727276e-08,0.028805181,-0.07031714,0.017521601,-0.041610826,0.010049235,0.052582886,0.0032712398,-0.02041441,0.009528548,0.04765032,-0.03608568,0.06890542,-0.04942051,-0.047394227,0.046247195,0.048918586,-0.034794882,0.018795123,-0.012172409,0.020738268,0.01675886,-0.028396325,-0.07463782,0.090321414,0.08617168,-0.040591322,-0.037891712,0.0054481,-0.0522163,0.04733924,-0.08567845,0.060293477,-0.03545954,-0.052193515,-0.12672691,0.04737251,-0.011867988,-0.027996331,-0.063685395,0.038005453,0.090844266,0.008873546,-0.05332071,-0.0060400316,0.020489145,0.007265555,-0.024766473,0.036816545,0.0033530511,0.029903641,0.044538856,-0.07568096,0.008807176,0.01681494,-0.1109698,0.039248742,-0.008181137,-0.04422581,0.02933726,-0.024975175,0.04879013,0.0143545,0.17717913,-0.060947668 +2.1.1.392,"The enzyme, characterized from the plant Rauvolfia serpentina (Indian snakeroot), catalyses the last step in the pathway for the biosynthesis of the monoterpenoid indole alkaloid ajmaline. Also reacts with 4-methylnorajmaline.",384,1.0,-0.008081041,0.011857355,-0.090854,0.023655713,-0.046231505,0.043888602,-0.11039911,-0.019652708,0.02749199,-0.009655502,0.0275327,-0.049832888,0.019912766,-0.039981943,-0.06670448,0.10417728,-0.023306826,0.07753446,-0.018952724,-0.060586262,0.05132879,0.034368165,0.029782152,-0.06252013,0.043885432,0.046237808,-0.050630417,-0.055737615,0.029677412,-0.0409157,0.020144824,0.0019560347,-0.008909682,-0.039913226,0.02698053,-0.019020569,-0.0919754,0.0072675883,0.10389849,0.062959395,0.031924944,0.01803153,-0.01918924,-0.026617752,-0.037572972,-0.058553822,-0.007990479,-0.019258177,0.062073816,-0.053008635,0.009787704,0.00036326252,-0.08478713,-0.039288063,-0.011356976,-0.10917566,-0.022761164,-0.027774729,0.0016696056,0.07665389,0.1231122,0.043519527,-0.041195586,0.063317835,-0.02025096,-0.106623605,-0.035701886,-0.0054846313,0.07544618,-0.05796047,-0.050716452,-0.043917708,-0.013663409,-0.012147503,-0.035596315,0.06007392,0.05493478,0.016945027,-0.040725667,-0.058917794,0.02289347,0.02092398,0.08367247,0.034430407,0.06689206,0.07806721,0.039434504,0.051380895,0.06130001,0.05505288,0.08726154,-0.0013641864,-0.015267347,-0.070389375,-1.0464074e-06,0.03865522,0.066117786,0.004319486,-0.0487316,0.03207138,0.022212155,-0.02133574,-0.043077826,-0.008603241,-0.021345662,-0.0068037086,-0.063777186,-0.031513333,0.0068480778,-0.0010611685,0.0031009582,-0.044625927,-0.023217045,0.056529526,0.007091792,0.055429395,-4.9578102e-05,-0.020176882,-0.013831435,-0.011760419,-0.044317674,-0.012917533,0.00090112694,0.031704817,0.006116097,0.0019300513,-0.08034701,3.620038e-33,0.033343412,0.0335363,-0.043544073,-0.046837907,0.024407808,-0.040759895,-0.06077285,0.042168073,-0.043128394,-0.00645347,-0.079589464,-0.00060698093,0.026757864,0.013985784,-0.060016412,-0.050875302,-0.04784965,-0.012186055,0.018088827,-0.101129286,-0.01387452,0.008783878,-0.043959755,0.048685815,-0.060798448,0.016499793,0.0055471417,-0.026989346,0.009643691,2.6331154e-05,-0.033951674,-0.092883125,-0.059026655,0.04239343,-0.053796552,-0.005332665,0.024158498,-0.07860792,-0.06141352,0.043529578,-0.01695904,0.06090552,-0.0011917233,0.06874444,0.03380629,0.03165041,-0.06498798,0.10275512,0.060753424,0.05542601,-0.07708491,0.017979503,0.13921288,-0.0026007262,-0.08803842,0.05073162,0.010891667,-0.024530068,-0.011474692,0.02379195,-0.05254467,-0.031788234,-0.05461914,0.026885612,0.007568465,0.020715611,-0.04077098,-0.11378948,0.069172956,0.04113966,-0.044453513,0.055330485,0.04473897,0.048450783,0.054053597,0.026862081,0.01777895,0.008900146,-0.061980788,0.017817652,-0.026098942,0.018189311,0.018160151,-0.050190885,0.07306213,0.0037146884,-0.017969767,-0.08922421,0.046508703,0.06619191,0.033509634,0.014685813,-0.1173438,0.06578877,0.03001788,-2.9920826e-33,0.06392252,-0.06741147,0.02389528,-0.04216193,-0.051042862,0.042149074,-0.04789392,0.046830222,0.0023251032,0.005137535,0.048672497,0.00727197,0.13593912,0.051959228,0.0220094,-0.09932006,0.08219452,0.08059121,0.016921623,0.05194927,-0.0876704,0.09690077,-0.058356255,-0.027827041,0.0674094,-0.036362685,0.008037973,-0.0020480256,-0.081097655,0.039229326,0.061866134,-0.014245677,-0.02972658,0.036661018,-0.012903034,0.090686075,-0.03885352,0.0129626505,0.0034407,0.13503607,-0.0025606898,0.039415136,-0.042300686,0.01242724,0.065467186,-0.0015071034,-0.053519845,0.11989669,0.007888711,-0.11266063,0.036659706,-0.023966469,0.07979217,-0.0028938951,0.06602535,0.03365308,0.047154807,-0.02811612,0.012000827,-0.0089981835,0.010104292,-0.044656195,0.026847228,-0.04465144,-0.004291948,0.123784624,0.063658,0.02352073,0.03342961,-0.013021138,0.08034211,0.043495394,0.011360864,0.06717444,0.05106425,-0.034207743,-0.018661544,-0.09358515,-0.056412637,-0.048020866,0.0034745182,0.059617605,0.060968187,-0.12764856,-0.012656132,-0.004000304,0.010228312,0.11963857,0.029275985,0.011996735,0.015823947,0.042081755,-0.0915546,0.08761965,0.10605192,-2.9914574e-08,-0.015423596,-0.0040514483,0.023070619,0.00074346137,0.0041493936,0.0692628,0.035298314,-0.070754595,0.014590107,-0.041416153,-0.0050221514,0.04605956,-0.036372963,0.039383054,0.009242643,0.012439356,0.016441269,0.032158755,0.004824781,-0.014344855,-0.011709073,0.015369201,0.0199167,-0.032596037,-0.029081259,-0.101836205,-0.012379865,-0.011666612,0.038589172,-0.035419527,0.029246427,0.038877476,0.0070938426,-0.066808365,-0.12277632,-0.0007656925,-0.0057960427,-0.0074423742,0.072006896,0.0039982186,0.04179704,-0.054349195,-0.026464434,0.0001945968,-0.05635886,0.0064876145,0.0018597541,-0.017504739,-0.010693097,-0.09563445,0.029177813,0.0004246733,0.04623515,-0.06605053,-0.071956195,-0.09354216,-0.07300886,-0.004960102,-0.07971162,-0.049943976,-0.041389603,0.005097331,0.15518638,-0.044711366 +2.1.1.393,"Isolated from the plant Rauvolfia serpentina (Indian snakeroot). The enzyme can also methylate norajmaline, with lower activity.",384,0.99999994,-0.00843295,0.03487862,-0.18558984,0.04896866,0.025920443,0.0740073,-0.111003324,-0.0003969563,-0.07009354,-0.03342776,0.032310866,-0.046694368,0.016789107,-0.024950482,-0.04818416,0.100643866,0.007136602,0.03008669,0.041305155,-0.0031040714,0.022528145,0.036436286,0.010230089,-0.021429097,0.018635143,0.042877097,-0.029332068,-0.01624622,0.07368025,-0.05890567,-0.040889278,0.056096982,0.0023724446,-0.042380147,0.055864964,0.04921413,-0.108653806,-0.006801262,0.051318273,0.05190466,0.07101366,0.0077217068,0.002636955,-0.0591281,-0.034762636,-0.02869059,-0.019537631,0.009046776,0.06277544,-0.07936612,-0.034102354,-0.015290401,-0.071214356,0.00656693,-0.061087795,-0.09095789,-0.006500755,-0.049221706,0.008235305,0.06684361,0.110242166,0.024257615,-0.023775995,0.013665512,0.015406404,-0.013121177,-0.0387533,0.021087741,0.11004931,-0.07372739,0.0045182747,-0.038667332,0.022541381,0.018091861,-0.06389383,0.03462151,0.11448154,0.004150745,0.015590036,-0.0014719312,-0.038413677,0.039675284,0.14026743,-0.009962458,0.085253336,0.080195464,-0.010111123,0.08097665,-0.009120364,0.040881913,0.06794864,0.05619407,0.01151147,-0.07271986,0.01251321,0.003997025,0.04681669,-0.030559594,-0.04178086,0.031311408,0.021189671,-0.051479723,-0.005417344,-0.037076328,-0.07225828,0.057347752,-0.022559086,-0.06845561,0.050207634,0.041173358,-0.047600646,0.031509023,-0.07613207,-0.0073364237,0.02586459,0.043619633,0.047381327,-0.029024554,0.01742445,-0.061662912,-0.037978496,-0.04176129,0.05932677,-0.03252532,0.035335954,0.026271481,-0.13757682,2.218024e-33,0.024568548,0.013986808,-0.032110002,-0.062062953,0.044133693,0.020509463,-0.0127489,0.006314743,-0.049797304,-0.01940884,-0.084869355,-0.0112138735,0.028428452,0.0066266316,-0.054711595,-0.065652184,0.03369247,-0.053378724,0.045013152,-0.11987614,0.07299951,0.063435085,-0.044558506,0.02772199,-0.028874788,-0.006906477,-0.017283574,-0.009234244,0.03451293,0.006389271,0.025131363,-0.123318516,-0.03749275,0.047442872,-0.04752762,0.012858262,-0.07856286,-0.09216068,-0.013235418,0.059240006,0.0085638575,0.033942953,0.062041182,-0.0033704583,0.014882138,0.0068172854,-0.057530932,0.02187196,0.03948156,0.019452384,-0.06079872,0.017205097,0.04255061,-0.041108206,-0.11971071,-0.0064339647,0.017912548,-0.013544836,0.043970432,0.028103089,0.0065084235,0.014439874,-0.029568221,0.00028113343,0.046963323,-0.0020603554,-0.0816449,-0.049531728,0.0004591017,-0.03630974,-0.025607446,0.047749225,0.090775356,-0.050719243,0.07677371,6.8334244e-05,-0.006597739,0.029756743,-0.050754406,0.00574749,-0.018912628,-0.0059877355,0.04948332,-0.0063271886,0.03760795,0.06298709,-0.016837215,-0.027999602,0.019396521,0.04100085,0.03697184,-0.026659844,-0.086217046,0.021721167,0.024697829,-1.0129482e-33,0.064240366,-0.031423416,0.07380288,-0.05044893,-0.03834736,0.07688207,0.040093776,0.00932445,-0.028502673,-0.03076477,0.07808066,0.021612858,0.0816423,-0.03105493,0.015496667,0.01887535,0.049159117,0.096583836,0.021186246,-0.000719979,-0.119228005,0.07434743,-0.03227274,-0.05274811,0.046759326,-0.05303514,0.044745844,-0.009798764,0.01266248,-0.008761502,-0.02047318,0.036057677,-0.02938096,-0.045660548,-0.067788266,-0.0012156095,-0.14221114,-0.077163205,-0.021975424,0.06639971,0.012509969,0.052410305,-0.034801904,0.031743616,0.011667147,0.044985957,-0.01796964,0.031038553,-0.003636955,-0.0072210156,0.08352858,-0.038209826,0.06741124,0.01749702,0.049953382,-0.006444432,0.05432342,0.021261288,-0.0045607868,-0.010193695,0.041212007,-0.020656442,-0.04842738,-0.007850777,0.07547015,0.17803514,0.03521673,0.027253317,-0.00027292324,0.007379486,0.09436971,0.065822355,0.02547353,0.07817672,0.016218124,-0.0002719012,-0.028586375,-0.044208683,-0.03850613,-0.06350436,0.054297358,-0.0110031385,0.0050205057,-0.06498206,-0.023440039,-0.02277634,0.033370577,0.09120231,0.046019115,-0.00084781623,-0.01386199,0.053377002,-0.11861976,0.0635941,0.16273175,-2.537653e-08,-0.009909471,-0.064752005,0.0056119724,-0.02928528,0.0070902086,0.032383166,0.032742273,-0.08517076,-0.005189303,0.07329258,-0.017739529,0.015935132,-0.005926156,-0.026734004,-0.006581842,-0.016266026,0.03596686,0.07141971,0.020058203,-0.041218624,-0.04258524,0.026464917,0.016239384,-0.0025606647,-0.02977185,-0.06192495,0.020420782,-0.009740205,0.08707627,-0.06270979,-0.012069457,0.033275705,0.017626723,-0.07865696,-0.08422177,0.029575195,0.0017687021,-0.01943751,0.009834197,0.010084059,0.070171036,-0.022908308,0.030831726,0.020350315,-0.07839165,-0.01981641,0.014224193,-0.011751955,0.0324683,-0.12958077,0.029981675,0.039507587,0.052436616,-0.09956807,-0.08018776,-0.037543435,-0.067324266,-0.038896974,-0.08532465,0.0045763724,-0.025735045,-0.05256632,0.11996101,0.004755705 +2.1.1.394,"A radical SAM (AdoMet) enzyme that catalyses two consecutive methylations during the biosynthesis of complex carbapenem antibiotics. The enzyme adds a methyl group at position 6, followed by a second methylation that converts the methyl group to an ethyl group. The enzyme binds a [4Fe-4S] cluster and requires a cobalamin cofactor and an electron donor. Methyl viologen can be used in vitro.",384,1.0,-0.08843078,-0.04841147,-0.1446851,0.017922416,-0.02158924,0.055033438,-0.045918256,0.0612578,0.025555257,-0.024380181,0.056291718,-0.0013248977,-0.036315076,0.04312097,0.009116168,0.058292817,-0.09129052,0.07638976,0.028958656,-0.022469742,0.038742077,0.038938545,-0.015119921,-0.04816031,0.015377603,0.048096925,0.040954895,-0.02775742,0.03394379,-0.026751569,0.102368094,0.03124722,0.09840253,-0.04491634,-0.047211282,0.062337015,0.007072018,-0.027008746,0.08681027,0.030901382,0.006135894,0.058676753,0.046442647,-0.059992123,-0.0004784605,-0.06233458,0.015108464,0.025264962,-0.008638946,-0.065671615,-0.08581641,-0.041855868,-0.05631476,0.026519433,0.0014557808,-0.027492233,0.008563928,-0.09594391,-0.021738209,0.0038939293,0.0935283,0.012169951,-0.032211892,-0.034887236,-0.055012748,0.004189338,0.04262375,-0.03366293,0.06086631,-0.014960215,-0.08580792,-0.06392819,-0.07625669,0.03725156,-0.041715145,-0.010311177,-0.026122177,-0.038722925,0.030909738,-0.04739698,0.04036451,-0.015912898,-0.030456439,0.08335231,0.08520354,0.030577553,0.020570116,0.012359081,0.05736009,0.061811704,-0.0114586875,0.0011754733,0.0030089468,-0.08794447,-0.09256464,-0.018591061,0.002019805,-0.017066015,-0.024789458,0.019141966,-0.03722975,0.09615325,-0.07614635,-0.0631636,0.009429227,-0.021677503,-0.00916396,0.03696581,0.011920691,0.016605467,0.015361637,0.048847616,0.03419304,-0.043971956,-0.03914831,0.049471043,0.03541177,-0.079461016,-0.023210974,0.03112593,0.015875775,0.015042598,0.01111628,0.0122630065,0.045630515,0.02899107,-0.09732078,2.0436436e-33,0.05261846,0.07968084,0.05164314,-0.024311692,0.02379601,0.010045968,-0.09167482,-0.021854589,0.061243452,-0.04496638,-0.07189685,-0.059127085,0.03847479,0.037436318,-0.021002017,-0.07772262,-0.050537247,0.0046951054,0.04167544,-0.028161816,-0.0710695,0.048914548,-0.10128991,0.022657394,0.015014094,0.04951818,0.055989325,-0.014866509,0.08688542,0.015967358,-0.03524675,-0.007933988,-0.15147692,0.007007047,0.006526622,0.023858473,-0.056024097,-0.11707616,0.07276951,0.03617461,0.05001089,-0.00028371956,0.038363058,0.073760256,0.038865227,0.026343133,-0.026736367,0.08800471,0.07378041,0.0702837,-0.0030484463,-0.015692016,0.04937263,0.031022787,-0.09514493,0.02851058,-0.012962917,0.06007604,-0.0119565055,0.074350335,-0.011667075,-0.061184287,-0.049063604,0.055711966,-0.042621322,-0.05568168,-0.04348028,-0.10365284,-0.02796814,0.074098356,-0.023728522,0.0027116342,0.120958894,0.0139223,-0.048695277,0.011235665,0.043109242,0.009931579,0.07078854,-0.038652122,-0.1128734,-0.010749837,-0.0050089713,-0.051226463,-0.01830777,-0.06834571,-0.0016037836,-0.03274396,-0.0442282,-0.050267152,-0.031560306,-0.0239497,-0.033740237,0.051271632,-0.010408303,-2.8625651e-33,0.010593313,-0.084369585,0.053053178,-0.028172005,-0.018827831,0.02216035,0.012588587,0.026878072,-0.010443293,-0.053889614,0.057336252,-0.03059243,0.09021427,-0.046348393,0.04559587,-0.012828003,0.03869197,0.024928352,-0.009997842,0.01150188,0.03543144,0.086293034,0.028468557,0.037808836,0.06629205,-0.009990206,0.017955892,0.039361507,0.01064128,0.09624062,0.106964916,-0.014446717,-0.06630967,-0.04087035,-0.05040016,0.1310099,0.08989243,-0.00071937917,-0.05934626,0.035777938,-0.017438889,-0.021063814,-0.020119209,0.12516262,0.064532824,0.07068507,-0.03924361,0.013826544,0.0086957505,-0.064734995,0.05471532,-0.026566783,-0.0067056958,-0.007489474,-0.04872897,-0.0011373772,0.027627539,-0.04667293,-0.054864135,-0.039191227,-0.044107184,-0.012677495,0.05997072,-0.018255072,-0.042792447,-0.013408432,0.07576604,-0.006564062,0.01553882,-0.015814532,0.022345828,0.057705555,-0.0011398352,0.05156648,-0.022916436,0.001084131,-0.07078267,-0.098256946,-0.045341007,-0.03441217,0.010029947,-0.031215463,0.007646415,-0.0021577494,-0.08018321,-0.0340652,0.039157595,0.11215368,0.028475832,0.00792304,-0.09359059,0.024964727,-0.07198097,0.08852668,0.0069396403,-3.6384858e-08,0.06243066,-0.05388765,0.063074864,0.003451887,-0.016521372,0.03356426,-0.11433095,-0.017977683,-0.0011646999,-0.028085945,-0.06093926,0.07750465,-0.08935082,0.06888168,0.011826995,0.025628697,-0.02058405,0.024895076,-0.03591702,-0.02500248,-0.032435052,0.05064404,-0.009851704,0.025571495,0.016354386,-0.009795466,0.039432406,0.03875974,0.03136258,-0.0007796864,0.1081224,0.061791755,-0.030847197,0.060000584,-0.14842518,-0.028816806,0.0026612896,-0.014044392,0.013898528,0.05937353,0.036544435,-0.05551641,-0.1499352,0.043595426,-0.026979836,0.028398607,-0.0357673,-0.010618444,0.0150826955,-0.023591463,0.038372744,0.022176338,-0.046896998,-0.0031387678,-0.08500131,0.03433308,-0.06482391,-0.015374861,0.03948627,-0.028558748,0.008268444,0.036868796,0.11692827,0.025764577 +2.1.1.395,"This activity is the penultimate step in the bionsynthesis of the alkaloid emetine. It is catalysed by two enzymes isolated from the roots of the tropical plant Carapichea ipecacuanha, IpeOMT2 and CiOMT1. The latter also catalyses the activity of EC 2.1.1.396, cephaeline 6'-O-methyltransferase, but with much lower activity.",384,1.0,-0.025738534,0.0036953778,-0.032138675,0.015577999,0.02573248,0.027437635,-0.07523854,0.01900642,0.10328753,-0.009744359,0.048148073,-0.1475966,-0.07323526,-0.09034643,-0.070786774,0.04840547,-0.045635518,0.046127934,-0.05361714,-0.044309422,0.04251053,0.0014234586,0.023823619,-0.007496151,0.049409684,0.029862445,-0.03919635,0.037890214,0.05091596,-0.14948876,0.10197931,-0.02023224,0.01722956,-0.0056417407,-0.006183226,0.02298947,-0.008740786,-0.06365191,0.050869495,-0.008770028,0.053518716,-0.04015824,-0.039630268,-0.07962238,-0.0545704,-0.08000621,0.013239265,-0.010105663,0.021256482,-0.07967171,0.02631245,-0.066099875,-0.04737372,0.034376733,-0.0034986588,-0.053531684,-0.020604782,0.031468365,0.0073576737,0.042028725,0.11623172,0.060330287,-0.02699852,0.02093874,-0.018555405,-0.07812198,-0.008909751,-0.0598193,0.011733955,-0.019087749,-0.053377055,-0.10392904,0.044150766,0.022201082,-0.028570361,0.09643172,-0.012608981,-0.06524036,-0.04022207,-0.05774108,0.014900577,0.045062825,-0.011079315,-0.0014712804,-0.0009931423,0.0066693723,-0.012472527,0.05202862,0.0377612,0.06115537,0.09077772,0.016703054,-0.04428483,-0.018688943,-0.028717896,0.096680254,0.005203096,0.041300155,-0.026577758,0.015329165,-0.0053756256,0.123887785,-0.10988986,-0.10191721,-0.046607897,0.020263558,0.024042103,-0.015263013,0.011412205,-0.06570121,-0.013749903,-0.08477079,-0.04793759,0.025832808,-0.007065437,0.11956954,0.014353911,-0.041829865,-0.004777673,-0.02812129,-0.038446095,-0.081340596,0.0009817565,0.014300108,-0.07101092,-0.012525396,0.0005523631,3.3627613e-33,0.08060931,-0.013929512,-0.040200323,-0.030848384,0.12856442,-0.010933461,-0.070296064,0.021482775,-0.07500882,-0.059772603,-0.10209487,-0.053547848,0.012051661,0.043023225,0.02339964,-0.046558328,-0.01049695,-0.03164285,0.052314978,-0.035833493,0.067021444,-0.034284264,-0.07172358,-0.00949564,-0.0350682,0.07139718,0.015214785,0.014237432,0.02390581,-0.004474996,-0.04207737,-0.0059087756,-0.065557234,0.05262472,0.019899664,0.053094033,0.009378037,0.03752517,0.023704931,0.06908949,0.03743618,0.040714268,0.008637379,-0.031593584,0.051527124,0.0038673864,-0.02339987,0.0812493,0.11993316,0.0409949,0.05994247,-0.041420396,0.06888005,0.028507909,-0.007969353,0.07275678,-0.08903607,-0.013399431,0.03500323,0.022977864,-0.020685311,0.0163928,-0.04663895,0.02310424,0.029159114,0.07893306,-0.07847053,-0.0057702907,0.00081686804,0.010023599,-0.06617027,-0.043776784,0.051450808,0.037919767,0.07972738,-0.017182345,-0.05326447,-0.0023143336,-0.027010992,0.037085455,0.0042631826,0.0062193237,0.0021386847,-0.060763143,0.0025062552,0.030979268,-0.07670728,0.04609334,0.023375511,0.09563682,-0.027011616,-0.017407622,-0.088746265,0.04975357,-0.014036062,-3.9217937e-33,0.069783375,-0.06716065,0.004099528,-0.07838859,-0.05860191,0.048335597,-0.050107818,0.01523853,-0.02447364,0.012415517,0.032954313,-0.013266763,0.11817635,-0.03530341,-0.031646937,-0.035960976,-0.026215168,0.12119269,0.0020313861,0.018200148,-0.060853545,0.035852738,-0.09680468,0.03258176,0.07032754,0.016736021,0.0759655,0.04287751,-0.0015809798,-0.0007542518,0.010994092,0.00053977524,-0.07761102,-0.022844175,-0.05735433,0.08910285,-0.040312134,-0.038450778,0.024135722,0.084919006,0.0008252427,0.05730864,0.02705973,0.05848466,0.11011735,0.057605296,-0.07235948,0.0387995,-0.0299934,-0.07715884,0.09868223,0.03345408,-0.0049686036,0.061726533,0.10138262,0.053827498,0.012473174,0.0016587912,0.025768548,-0.056561485,-0.02062771,-0.02368342,0.0007024747,-0.019918863,0.06474631,0.015568453,-0.010126459,0.109475896,-0.008901978,0.0064629912,0.09686509,-0.050409127,-0.06220456,-0.014383077,0.010728032,-0.020284891,-0.052050393,-0.06932898,-0.001586793,-0.029565394,0.010403984,0.0003332331,0.032108713,-0.14542402,-0.019342912,0.011886919,0.030047469,0.094252504,-0.018346922,0.02149308,0.0056372876,0.026476873,-0.04674396,0.060232684,0.10376245,-3.945269e-08,0.028004035,-0.09433742,0.03568809,0.028543623,0.005118061,0.040907893,0.04119258,0.020861644,0.024379151,-0.04096781,-0.033649456,0.014684778,0.040880393,0.055253137,0.008607373,0.007960981,0.10541949,0.05111442,0.019275397,0.026144404,-0.05172231,-0.021024877,0.004796327,-0.02484141,0.036023844,-0.07003756,0.028178733,0.031463906,-0.03190801,0.02378092,-0.016909216,0.015393416,0.023347553,-0.029551743,-0.0047791414,0.07203533,-0.028885728,-0.11198995,-0.02321445,-0.07396525,0.012273734,-0.08047041,0.019236298,-0.02661124,-0.04556848,0.0069727623,0.019622037,0.019902596,-0.009748636,-0.021346414,0.05075299,-0.07393888,0.030591223,-0.07865998,-0.07390991,-0.03616584,-0.045134973,-0.03044311,-0.044339534,-0.07268532,0.032203887,0.029547242,0.107216135,-0.038163133 +2.1.1.396,"The enzyme IpeOMT1, isolated from the roots of the tropical plant Carapichea ipecacuanha, catalyses the final step in the bionsynthesis of the alkaloid emetine. A second enzyme isolated from the same plant, CiOMT1, also catalyses this activity, but catalyses the activity of EC 2.1.1.395, 7'-O-demethylcephaeline methyltransferase, with a much higher activity.",384,0.99999994,-0.04041431,-0.004768019,-0.04228689,0.020629046,0.04635103,0.023129003,-0.07508937,0.017571364,0.08042937,-0.024162704,0.063185774,-0.115502186,-0.08461789,-0.08089947,-0.063850455,0.07544184,-0.059910104,0.031483356,-0.023088958,-0.047444224,0.06376271,0.014143782,-0.0013161636,-0.024382913,0.06809955,0.041453972,-0.036274426,0.027712438,0.048969552,-0.13527891,0.06429659,-0.04379049,0.01685455,0.008642072,0.027061066,0.028029064,-0.025156576,-0.050788775,0.036561094,-0.0010505083,0.04525744,-0.007550564,-0.034293823,-0.072335415,-0.06356541,-0.078186475,0.03730092,0.0069348034,0.01311523,-0.064303845,0.003396139,-0.05446592,-0.026374513,0.020310739,0.014690004,-0.066594176,0.004560657,0.026798407,-0.029007548,0.05126588,0.094786584,0.068970524,-0.04772482,0.000528387,-0.006786304,-0.07243299,0.0076535805,-0.033140734,0.03891407,-0.029876636,-0.0604903,-0.08510444,-0.010761241,0.022697585,-0.038117886,0.10202193,-0.007729857,-0.052675143,-0.012579618,-0.038494352,0.01802015,0.060218308,0.007812976,0.011027625,0.0004458626,0.010917542,-0.007433661,0.08299519,0.029854491,0.031838503,0.07530376,0.011629969,-0.04634278,-0.034399856,-0.0073153516,0.07524435,-0.006642564,0.025154099,-0.030571997,0.017016064,-0.010120257,0.11208525,-0.10416895,-0.11364849,-0.06290541,0.051825095,0.006641165,-0.036242995,0.03746235,-0.030692462,-0.040224228,-0.056237146,-0.024472296,0.049882956,-0.009405566,0.097491525,0.029870033,-0.014759251,0.023176057,-0.021341179,-0.05990641,-0.10787663,0.028664313,0.022307005,-0.05389946,0.029533828,-0.02427524,2.3111387e-33,0.07188662,-0.0100619225,-0.04553146,-0.04267104,0.12195974,-0.0076215845,-0.027380113,0.04287359,-0.08887539,-0.026831761,-0.0961867,-0.09633947,0.02143501,0.05168716,0.0012040179,-0.035202406,-0.02036459,-0.0253732,0.05105231,-0.030439567,0.04410988,-0.011090511,-0.080569744,-0.024980228,-0.045470674,0.059359476,0.014457501,0.0171445,0.04353968,-0.0056138886,-0.03132058,-0.008351012,-0.08007977,0.03991356,0.009996038,0.04097353,0.010845174,0.00810078,0.028132187,0.070304364,0.0029752466,0.05584635,0.025937041,-0.06204517,0.062282015,0.026990121,-0.050622966,0.08527628,0.09660256,0.024625087,0.018850962,0.019714357,0.068900704,-0.0020100537,-0.0053543164,0.056556847,-0.07626345,0.008719695,0.06230635,0.022564484,-0.02185726,0.04022659,-0.030415962,0.019268416,0.04143369,0.068872705,-0.087213986,-0.0101016,0.018875325,0.051553003,-0.029980803,-0.053119548,0.00026913814,0.003609461,0.071936026,-0.04502538,-0.04220681,-0.005637398,-0.016271502,0.033241697,-0.017342692,0.011556557,0.02092488,-0.06846578,-0.013169516,0.00795845,-0.047732454,0.052518956,0.0066831573,0.09269472,-0.021749418,-0.010910099,-0.0918608,0.045312673,-0.0073017604,-2.659287e-33,0.049648315,-0.06876981,0.002150716,-0.11232077,-0.0882787,0.06449646,-0.031004988,0.028033117,-0.023680544,0.03203138,0.04764259,0.0065367557,0.0944881,-0.03759226,-0.014812394,-0.04641865,-0.041317616,0.097388096,0.01509842,0.057630382,-0.051745534,0.06652097,-0.08144647,0.053625856,0.06504663,0.0005914704,0.06859413,0.08383202,-0.0034223092,-0.030432507,0.016581254,0.019855669,-0.06347807,-0.039715745,-0.077578284,0.09188773,-0.05168147,-0.07005808,0.0065142736,0.114230864,0.008994289,0.07855668,0.03313756,0.05464419,0.08007127,0.030647308,-0.106752306,0.017213214,-0.016734662,-0.11278788,0.0664315,0.05228158,0.039885033,0.04997724,0.11065364,0.04660191,0.020662863,0.0109094605,-0.017027425,-0.061247867,-0.0076099904,-0.047164902,-0.010118106,0.008846887,0.076835446,0.04301409,0.016572338,0.08843543,0.002342547,0.011425396,0.082754284,-0.010353126,-0.02785943,0.012426659,0.016942069,-0.01865225,-0.048736278,-0.053040087,-0.024866125,-0.055439226,0.048766132,-0.015692787,-0.002097887,-0.15316561,-0.007687436,-0.01666311,0.046537034,0.12858672,-0.012501498,0.057713404,-0.0061520487,0.04163359,-0.07755062,0.05669804,0.10355735,-3.827884e-08,0.021701181,-0.10319219,0.065253444,0.014933294,-0.04462699,0.034410775,0.03840816,0.0049555986,0.007956574,-0.032969665,-0.023290358,0.038257692,0.029064137,0.071264386,0.008905458,-0.011799113,0.09538228,0.049610768,0.020054134,0.04445785,-0.062211517,0.020453265,-0.015203591,-0.042283487,0.027959073,-0.0685395,0.039574683,0.02559171,-0.025864424,0.027499992,-0.027580876,0.017791092,0.018047795,-0.046273302,-0.013798764,0.06622694,-0.032072097,-0.10176723,-0.018551867,-0.08475205,0.030384917,-0.07635797,0.007872321,-0.029796429,-0.03658438,-0.008829156,0.01804492,0.00215443,0.014081288,-0.02263817,0.053351954,-0.056265883,0.025851622,-0.10082477,-0.03929357,-0.050114524,-0.071093515,-0.022440795,-0.048009053,-0.054127842,0.027925933,0.01945843,0.12979248,-0.03248979 +2.3.1.317,"The enzyme, characterized from Pseudomonas aeruginosa and other bacteria, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). It participates in an L-carnitine degradation pathway. cf. EC 2.3.1.247, (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase, EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase.",384,1.0,-0.09810563,-0.057791527,-0.051029004,-0.012902525,0.057551652,0.045731112,-0.08196593,0.018634638,0.0067914594,-0.013998386,0.016596997,-0.070244655,-0.06022053,0.027625144,-0.092063904,0.048256706,-0.069101185,0.007986438,0.008208536,0.023884574,0.047550388,0.07295073,-0.04677028,0.03945121,0.08474605,0.06271953,0.05584667,-0.018952549,-0.022312757,-0.06691105,-0.10498649,-0.119612314,0.08844989,-0.04457884,0.075417645,0.07557822,-0.062323064,-0.05589042,0.06828154,0.028354688,0.033586,-0.04496512,-0.035873093,-0.081088856,0.051069718,-0.014691594,-0.06007886,-0.0072107213,0.062486723,-0.07073817,-0.0136633,-0.0959237,-0.015804693,0.0967734,-0.025880277,-0.007957044,-0.020617386,-0.02155728,0.005207651,0.08802051,0.018419039,0.04173011,-0.01693082,0.014693967,0.01647233,-0.035358757,0.026564678,-0.04589963,0.015813403,-0.02338678,-0.09704994,-0.086944334,-0.002919733,0.07821672,0.026939215,-0.0769155,-0.009604809,0.036693648,0.007994159,-0.03322119,0.07621625,-0.031357624,-0.012173326,0.014659877,0.013911102,-0.01868001,-0.04744355,-0.024659725,0.033337522,0.020927122,-0.017599918,-0.008653553,-0.049100094,-0.07112474,-0.035409793,0.011924905,0.041857056,0.045131788,0.02421006,-0.012700549,-0.011026048,0.11411352,-0.029843822,-0.08519378,-0.03733968,-0.007435006,0.055073224,0.072084405,0.043152593,-0.041109696,0.014325374,-0.0132493125,0.014000477,-0.02568422,0.0025743577,0.0684027,0.016496448,-0.07381713,0.031611808,0.050240185,0.007124756,-0.054521095,0.06289595,0.06178012,0.0054376246,0.037431896,-0.07159651,9.3707195e-34,0.059511516,0.03920388,0.008121854,0.005021553,0.033287786,-0.06496403,-0.08624007,-0.02681109,0.033041902,-0.08717894,-0.040558763,-0.035944007,0.039044335,-0.0008708734,0.028197823,0.08019028,-0.07223716,-0.018314473,0.05764231,-0.008439549,0.042580254,-0.03483319,-0.04894143,0.04530496,0.03316369,0.050400022,-0.018504584,0.022512648,0.024992589,0.02788968,-0.0104685435,-0.010137216,-0.06355332,-0.039665014,0.0050865607,0.008169808,0.016272867,-0.049750566,0.021228122,0.08200287,0.059366204,-0.0026706615,-0.042299658,0.0035331163,0.029252773,-0.04631751,0.0010590785,0.09498279,0.024370551,0.05143777,0.054356154,-0.10906441,0.03909133,-0.032251853,-0.05921275,0.09247314,-0.007767541,-0.0069435453,0.010223779,0.047119763,0.050109517,0.051831204,0.013829195,0.031904425,-0.013271052,-0.014688019,-0.11613387,-0.011006266,0.011779056,0.017567772,-0.10969393,-0.009337717,0.081969924,0.040390734,0.033138182,-0.07331459,-0.10895702,0.045098588,0.014746471,0.02371513,0.019755423,-0.064628914,0.0482939,-0.06296432,-0.036560148,0.001568888,0.041351914,-0.07494647,0.0025354975,-0.007573203,0.041523874,-0.05056926,-0.053471886,0.060184803,-0.008870409,-2.2023318e-33,0.17260079,-0.091150075,0.058799464,-0.054436937,-0.04329774,0.059682503,-0.009952379,0.03966392,0.035703536,0.029755414,0.07046564,0.02970426,0.07233369,-0.013545485,0.08780155,-0.020074017,-0.028317412,-0.020276621,-0.07096705,-0.041324098,0.06304305,0.00068210775,0.009924518,0.03152863,0.07514168,0.04112753,-0.11031913,0.107899204,0.10311399,0.024184616,-0.020185575,0.01976388,-0.005110602,-0.041850466,-0.04696306,0.0853245,-0.020574583,0.032876376,0.008938321,0.033905577,0.013642761,-0.0034280815,-0.05384091,0.029354265,0.021193514,0.077139676,0.03551992,-0.030814817,0.041575354,-0.15016262,0.05057802,0.00256227,-0.07013498,0.058999512,0.0034724197,0.045409396,-0.047300324,0.047917765,-0.04100008,-0.029486038,-0.026833035,-0.063022114,0.04173478,0.0009196401,0.06755947,-0.01403445,0.011160364,0.06525768,0.021262452,-0.0051187044,0.040461287,-0.005994756,0.035495188,0.002897448,-0.06774537,-0.043714605,-0.053561635,-0.0338024,-0.0020211008,-0.060123745,0.007370352,-0.047065295,-0.047016,-0.011341484,-0.047140155,-0.044116016,0.01639474,0.12959918,-0.029664366,-0.008186046,-0.026767563,0.009710754,-0.06346712,0.056742128,0.01187365,-4.327057e-08,0.09718428,-0.028749553,0.028585995,-0.0029010735,0.027347606,0.06344039,-0.028416958,0.054371443,0.060708582,-0.05737451,-0.069141075,0.08502335,0.001960737,0.022525847,-0.028201487,-0.004423488,-0.037254,0.05532601,0.018877065,0.028025463,-0.04867629,-0.08284534,-0.022162069,-0.011079181,0.0019696264,-0.053561985,0.049999986,0.11899617,-0.025938401,-0.05841167,-0.07339914,0.05945257,0.018947368,0.0012612259,-0.06575663,0.029474717,-0.027797978,-0.02716401,-0.050204866,0.020326301,0.029963141,-0.039055385,-0.1265258,0.0032068545,0.0077765924,0.06194596,0.041087884,0.027312633,0.019914964,-0.09050785,0.030053176,-0.045129802,-0.033926174,-0.0153092705,-0.0804627,0.019402744,-0.028384142,-0.039917458,0.009054156,-0.05863188,-0.0068452084,0.01893227,0.16483563,0.030971829 +2.3.1.318,"The enzyme, characterized from the bacteria Pseudomonas aeruginosa and Cupriavidus necator H16, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). cf. EC 2.3.1.247, (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase, EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase.",384,0.9999999,-0.05683409,-0.040338363,-0.046145413,-0.05444687,0.049040332,0.023852944,-0.09806334,0.025075296,0.005936299,-0.003999131,0.038201183,-0.12577018,-0.06613558,0.040598713,-0.09032917,0.020527797,-0.03611097,-0.009260155,0.022094686,0.010910608,0.041784305,0.04378428,-0.07808436,0.023681685,0.07263737,0.080395445,0.07157162,-0.016420215,-0.025392748,-0.07212594,-0.10544497,-0.11601084,0.08500762,-0.028561695,0.07286193,0.074235395,-0.054092295,-0.07189823,0.08836018,0.04491349,0.042905167,-0.025382323,-0.017823886,-0.06527874,0.029732026,-0.01136147,-0.03348676,0.015635414,0.091895245,-0.081692316,-0.012993162,-0.082079485,0.009220958,0.1088472,-0.018349824,-0.007832143,-0.005784994,-0.027905442,0.014786863,0.06349281,-0.033892624,0.026287429,0.0029728003,0.0024255991,-0.024854777,-0.06121656,0.025790825,-0.024271632,0.014956693,-0.004619159,-0.071711935,-0.06851008,-0.02104538,0.052713268,0.023518512,-0.059020728,-0.019582268,0.010374465,0.030809257,-0.018860634,0.04344857,-0.02545223,0.022188446,0.03300135,0.027787566,-0.012317075,-0.016389333,-0.020981947,0.038412243,0.007778935,-3.3761473e-05,-0.021405129,-0.0488235,-0.08606877,-0.04480685,0.026636388,0.0049977917,0.08277753,0.04454091,-0.02622011,-0.038090385,0.08835094,-0.048285592,-0.09147945,-0.022693034,-0.002568985,0.0428972,0.07691074,0.08580467,-0.03510419,0.0067099724,-0.030565176,0.01797081,-0.018464299,0.03797574,0.072844855,0.024628457,-0.10517907,0.007816889,0.050175432,0.022858333,-0.066444024,0.087313384,0.058204267,0.000133899,0.041659728,-0.09032356,2.5160057e-33,0.059742764,0.06488007,0.014833964,-0.03343023,0.03450646,-0.0683976,-0.076601386,0.03125198,-0.0012657436,-0.06654192,-0.08443169,-0.058225438,0.023242775,-0.021615822,0.023599375,0.030759973,-0.060752697,-0.02722974,0.037736546,0.0207697,0.04069654,0.0026200602,-0.047280043,0.035586763,0.03361538,0.032886583,-0.024242178,0.01921596,0.07040247,0.010068292,-0.019143745,-0.03867484,-0.041360516,-0.011157569,-0.0461668,0.019551162,-0.0017869545,-0.043756813,0.027966421,0.037946112,0.05259942,0.0038495124,-0.047396433,-0.030726653,0.05064199,-0.007866507,-0.012767048,0.06440635,0.033724215,0.047059078,0.037439432,-0.06704448,0.05482694,-0.0569202,-0.04515826,0.047463898,-0.018766599,0.009836143,0.056226954,0.041691847,0.01568321,0.053768657,-0.015637724,0.030370178,-0.020004746,-0.03705433,-0.08821221,0.013039666,0.024580624,0.012108571,-0.10218297,0.00024089553,0.016264353,0.03327575,0.040559415,-0.08319157,-0.102283634,0.010243705,0.017767323,0.028284127,0.022848638,-0.025390506,0.058658227,-0.046887998,-0.051333603,-0.0005713682,0.019150194,-0.023250638,-0.014094901,0.017972846,0.041210752,-0.049140725,-0.06303424,0.0886744,-0.009575249,-3.667022e-33,0.16591626,-0.113892555,0.06387304,-0.07224043,-0.050243337,0.08879988,0.022472741,0.052027926,0.06850851,0.00435416,0.103862055,-0.00024382255,0.06051335,-0.0038991373,0.051894207,-0.0194803,-0.05103817,0.021648593,-0.078402564,-0.04275053,0.05955776,0.027823962,-0.029450197,0.020669006,0.07750678,0.036079243,-0.07228414,0.13416217,0.060148146,0.058588896,-0.0059909937,0.017225588,0.012101179,-0.023137484,-0.06358287,0.08055183,-0.0035068982,0.024744155,0.016733611,0.02696602,0.004093291,0.011639778,-0.040908154,0.07535601,0.014010874,0.08832459,0.014793627,-0.017130807,0.03444613,-0.14908524,0.019799365,-0.016871586,-0.066592224,0.048082862,-0.011221653,0.023638997,-0.05330408,0.037670113,-0.015855417,-0.06437861,-0.036347006,-0.082503445,0.030153852,-0.0067564086,0.056349155,0.019674636,0.0062795146,0.045476366,0.011521514,-0.033930928,0.024654267,0.019407922,0.0041007036,0.026749399,-0.030139375,-0.036493868,-0.043313175,-0.040284537,-0.0022055856,-0.07188494,-0.015373075,-0.06068857,-0.060414065,-0.025361128,-0.022909706,-0.043271422,0.05038865,0.08190742,-0.076911956,0.019175384,-0.0478634,0.0110164555,-0.037370786,0.068402745,0.0016846629,-4.7341782e-08,0.09563194,-0.05168665,0.04382208,-0.023092655,0.035169017,0.06510407,-0.0061543663,0.03144984,0.07213503,-0.058168683,-0.035614405,0.086001955,-0.012952104,0.018927531,-0.015128868,-0.033429414,-0.041704226,0.04393626,0.020059612,0.0019625265,-0.040689263,-0.070500314,-0.0011513706,-0.00067488017,0.006275303,-0.049656812,0.049903408,0.10370152,-0.017337656,-0.074850485,-0.10785897,0.06174437,0.034553785,0.012327831,-0.039892998,0.04517161,-0.039124627,-0.00092300196,-0.048130486,0.011524469,0.052100793,-0.07606791,-0.13552539,-0.031666055,0.026752831,0.048270803,0.048206467,0.033940118,0.025241755,-0.0894191,0.06386499,-0.023864089,0.021463389,-0.0052240575,-0.080352485,0.023758452,-0.03270344,-0.07842202,-0.032642156,-0.05395464,0.05208,0.0019733277,0.19192792,0.037056502 +2.3.1.319,"The enzyme, characterized from fungus Blumeria graminis, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). cf. EC 2.3.1.247, (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase, EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, and EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase.",384,1.0,-0.04338794,-0.08344507,-0.04686615,-0.06400136,0.04691629,0.03783167,-0.07439039,0.010730638,-0.00352799,0.024158295,0.07235721,-0.06674238,-0.06939655,-0.016775401,-0.093368955,0.08180151,-0.03412578,0.03205107,-0.013290613,-0.042808313,0.08344385,0.07485126,0.0035985897,0.0949794,0.041526638,0.046136416,0.073299944,-0.023367487,-0.051468585,-0.10165426,-0.111127384,-0.07037506,0.07068474,-0.03240729,0.022809438,0.050392047,-0.09199012,-0.05284722,0.056734554,0.051814295,0.021927338,-0.06357027,-0.039054576,-0.06939193,-0.036470324,-0.044410013,-0.045441948,0.032318324,0.07116991,-0.047050882,-0.0082578175,-0.09516791,-0.013455397,0.06467763,0.006025064,0.006528828,-0.043980274,0.0027027098,0.052294686,0.0998653,0.0114021255,0.05732485,-0.0069174967,0.011005744,-0.004392856,-0.018833129,0.021400727,-0.05310164,-0.051744506,-0.05260114,-0.06324574,-0.10067583,-0.013001558,0.05263231,0.046513725,-0.042884197,-0.023444396,0.012664099,-0.006030233,-0.038919996,0.053489402,-0.028491916,0.001359509,0.00896743,-0.019083915,0.01125917,-0.030403832,0.024818607,0.022138048,0.0037378457,0.041968327,0.016334632,-0.023688247,-0.040515743,-0.062393945,0.07481087,0.022839462,0.08752406,0.071359225,-0.026088519,-0.017860867,0.035482474,-0.012545463,-0.09252191,-0.10105247,-0.027066179,0.030096734,0.052683547,0.09992606,-0.034321267,0.015912192,-0.036368012,0.0247337,-0.01438704,-0.01304941,0.053640615,0.045511723,-0.05939766,0.039187387,-0.018602727,0.053207718,-0.007807152,0.040366676,0.041043226,-0.026804661,0.042231034,-0.09979821,1.9241199e-33,0.10477406,0.07231473,0.022842117,0.027501522,-0.009290355,-0.06983068,-0.048072584,0.034799416,-0.03473391,-0.08770482,-0.10975231,-0.04381937,0.012831379,-0.034659438,0.058624163,0.071856834,-0.03836286,-0.011086442,0.037311375,0.070580415,0.030468978,0.01783805,-0.12033469,0.04214529,0.0519485,0.034791365,-0.01354862,-0.016374044,0.0902021,-0.0014437399,0.028568676,-0.01774563,-0.05924597,-0.019545596,0.004513269,-0.016485928,0.012756979,-0.016816221,-0.038587973,0.0016991331,0.0032984067,0.0017160001,-0.06861766,0.010536532,0.043918524,-0.025644368,-0.007186423,0.038069006,0.059068117,0.07318913,0.020420799,-0.009770286,0.11615111,-0.0042586196,-0.0070727128,0.10574537,0.011981466,0.0019489912,0.019497316,0.06680015,0.009933951,0.09768255,0.017418329,0.012380847,0.0058344966,-0.046317093,-0.11575444,-0.011039186,0.0014870592,-0.06153631,-0.096069604,0.014004969,0.0046495297,0.0021529407,0.053978514,-0.080857895,-0.0746283,-0.0013449899,-0.03215025,-0.015714398,0.0028238767,-0.049607705,0.086186394,-0.052438267,-0.048178583,0.02055702,-0.03957248,-0.04662382,-0.005586308,-0.0069362493,0.038821075,-0.08386837,-0.05954524,0.053185396,0.004981423,-3.110926e-33,0.15969989,-0.09917692,0.02942286,-0.009587292,-0.034789737,0.07878677,0.01412575,0.037329264,0.0049106358,0.0007873576,0.07786297,0.027592024,0.041401066,-0.008505509,0.07481069,-0.007640548,-0.025616191,0.074925065,-0.07760681,-0.030778673,0.014056475,0.07105655,0.035106577,0.011753939,0.048966736,0.018189264,-0.034282617,0.13968962,0.04956352,0.029063608,-0.011031563,0.02235836,0.0102089,-0.03414185,-0.043824133,0.06498111,-0.025672808,-0.0075996765,0.028155863,0.08725706,-0.053395353,-0.009573268,-0.04797386,0.006903666,0.010784813,0.054705292,0.0053994455,0.024477994,0.023814121,-0.117972754,0.025731467,0.027606145,-0.048165563,-0.009010379,0.047462896,-0.0072530736,-0.024960255,0.046636928,-0.011766177,-0.05418078,-0.046369307,-0.036255956,0.028567363,0.038659662,0.054776773,0.042494927,-0.01881187,0.03270123,0.04849474,-0.05760593,0.019316217,-0.019191181,0.020266445,0.09225644,-0.013285039,-0.05619832,-0.03224439,-0.038518943,-0.023727218,-0.014455107,0.029950123,-0.046544764,0.015756754,-0.072461225,0.0033356387,-0.06870422,0.04083423,0.06041122,-0.07582792,-0.017043466,-0.006827339,0.0171938,-0.059429467,0.07808149,0.028594462,-4.274631e-08,0.096600756,-0.025154715,0.032087583,-0.05484048,0.051920194,0.024456695,0.034469604,0.035053417,0.05962144,-0.032084648,-0.104304396,0.07031902,0.027200675,0.094754845,0.015152065,-0.013224403,0.0030074134,0.025334306,0.0022627537,0.050220586,-0.041906122,-0.07888462,-0.057280116,0.011719725,-0.018245421,-0.07639506,0.05034576,0.10361804,0.05143386,-0.042692494,-0.0641224,0.063182205,0.01899275,-0.020653583,-0.04075559,0.047336895,-0.089339785,0.038449004,-0.04834115,0.048306607,0.014473427,-0.08662736,-0.08379564,-0.017123874,0.015970388,-0.026176848,0.018889057,0.07608777,0.062685214,-0.08673895,0.012031589,-0.004111778,-0.03674607,-0.04678222,-0.07682015,-0.047561795,0.027259478,-0.019328915,-0.005026912,-0.09841958,0.008640025,-0.011376564,0.13950154,0.029602785 +2.3.1.320,The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew).,384,0.99999994,0.026999494,-0.037280414,-0.08737736,-0.02380763,-0.006880582,0.035346534,0.0022758502,0.016969893,0.06169355,0.033253826,0.023705494,0.027522009,-0.05725938,-0.011539202,-0.005478382,0.020733038,-0.050969563,-0.008620919,-0.0084521165,-0.0073786597,0.16442992,0.009689063,0.081201516,0.063977085,-0.05847025,-0.070030995,-0.041582383,0.013904367,-0.012740418,-0.08491651,0.026483983,0.008148715,-0.031934593,-0.012427247,0.033054035,0.03696193,-0.02467943,-0.0020834822,0.056466646,0.050645437,0.04219796,-0.06251721,-0.10787404,-0.024139531,-0.0979479,-0.08343627,-0.022648629,-0.050862234,0.10400316,0.08768316,-0.06526235,-0.073277704,-0.05428387,0.015111473,0.009783874,-0.0046300367,-0.022036927,-0.024865225,-0.014998975,-0.046106953,-0.018655697,0.020362493,0.0035269256,0.02420227,-0.021779208,0.038305152,-0.037303954,-0.019089833,0.0057645305,-0.08647316,-0.057969116,-0.0706051,0.03677106,0.04084559,-0.06807526,0.010158394,0.043098215,0.071330786,0.060150087,-0.096732125,0.04163757,0.05795205,0.024863448,0.10624089,0.037698362,0.014049579,0.07740755,-0.0066916337,0.10641366,0.008894337,0.03694647,0.029859506,-0.02065164,-0.0010725611,-0.021676287,-0.03393242,0.06253629,-0.045741223,-0.0026763438,-0.011377853,0.02149432,-0.0059223063,0.0034860012,-0.14659198,-0.06967752,0.05926153,-0.11352372,0.05429858,0.015965618,-0.03484564,-0.0074893115,0.030286476,0.016803553,0.08093409,-0.00094507507,0.11715449,-0.050187413,-0.096504495,-0.0820737,-0.091171496,-0.030344492,-0.07737287,0.02713573,-0.017700823,0.009812989,0.015731875,-0.01598847,-3.214374e-33,0.04387508,0.00058664416,-0.011606563,-0.072680674,0.042224515,-0.0338712,-0.015756954,0.047360435,-0.1340501,-0.012526832,-0.08667987,-0.07055259,-0.043369908,0.027289044,0.027667942,0.015802221,-0.014389837,0.018095013,-0.0017672554,-0.017868733,0.015838556,0.07435636,-0.0038991566,-0.038335845,-0.05709889,0.09934669,-0.041089263,-0.015000219,-0.005151052,0.0031043098,-0.0070910035,-0.11136282,-0.025562506,0.033397123,0.018590996,0.067117356,-0.0035123827,-0.039717305,-0.013960338,0.029441046,0.03969226,0.025683608,0.083243795,-0.054032397,0.0015046025,-0.030138515,-0.01992324,0.02401422,0.0774335,0.043219734,0.009579716,0.01957249,0.07871263,0.0034996576,-0.080771394,0.055934638,-0.04690406,0.022989662,-0.012453341,-0.0047129346,0.042059805,-0.014318905,-0.011138845,0.038449965,0.0032907946,0.052453425,-0.072805874,-0.00864497,0.033009157,0.10598759,-0.07761935,0.011900483,-0.0008060777,-0.005488353,0.06515148,-0.024242757,-0.0093976,-0.010160069,-0.02937559,0.06632798,-0.032451626,0.0029625678,-0.05142094,0.06256732,-0.049207326,-0.021987427,0.025597122,0.048312765,-0.057569113,0.005369382,0.044858072,-0.06643614,0.0017810431,0.03947288,0.012750168,2.3836006e-34,0.07395594,-0.0969779,0.07789289,-0.04314858,-0.05209646,0.12558767,0.019795047,-0.019751025,-0.01652851,0.0355629,0.027974077,0.06720682,0.04322896,-0.032345243,-0.03821582,-0.027214829,0.051393606,0.047315244,-0.05062408,-0.048583556,0.0022063206,0.12728536,0.017692858,0.061201435,-0.025755702,-0.007744138,0.057085793,0.082587436,-0.033545252,0.022289883,0.047333945,0.05173717,-0.050187923,-0.017901467,0.0015419701,0.019695442,-0.030265857,-0.05065158,0.007484653,0.041970603,-0.042652268,0.0065650055,0.012461409,-0.012135565,0.043869704,0.0017738241,-0.1058473,-0.0033501394,-0.05446482,0.038879093,0.06357606,0.04214838,-0.00077613816,-0.0019606354,0.008629563,0.06486313,-0.035589814,-0.015142196,-0.0051987562,-0.02463285,-0.07678065,-0.0057607414,0.006005221,0.017200736,-0.010719421,0.022562992,0.010267795,-0.031579185,0.09493555,0.0057596886,0.06283198,0.057586662,-0.06800301,0.081774816,-0.0049219783,0.019178974,-0.023499325,-0.07573057,0.027974224,-0.0206289,0.03495533,-0.011471544,0.038514696,-0.11097902,-0.044351436,-0.0073159155,0.0054568443,0.09752791,0.054241493,-0.00384668,0.033043742,-0.100065984,-0.030929597,-0.021912348,0.02687861,-2.4628875e-08,-0.00968599,0.014847213,0.02472421,0.031317692,-0.05715266,-0.012830492,-0.011506026,0.013292903,-0.015205916,-0.07584168,0.06358011,0.05173933,-0.011331784,0.050727718,-0.00077228463,0.010693291,0.025089273,0.079814136,-0.045123223,-0.039581403,-0.08912538,-0.049377125,-0.09364802,0.08954568,0.023069445,-0.08557312,0.025082545,0.042638626,0.024432357,0.0060398974,0.0002686705,0.009588582,-0.057955973,-0.038008336,-0.056203526,0.06366681,-0.0046292823,-0.015290032,0.048514124,0.06760596,0.07366895,-0.07867468,-0.035500538,-0.041755214,-0.042639505,0.03793783,0.027607223,-0.056383543,-0.00061774283,-0.012213888,0.044897653,0.010966554,-0.02476742,-0.09217088,-0.15224548,-0.011476004,-0.042556558,-0.06709309,-0.02241028,-0.102734774,0.07597615,-0.015203583,0.1981501,-0.03899879 +2.3.1.321,"The enzyme, present in Taxus species (yew) catalyses the final step in paclitaxel (Taxol) biosynthesis.",384,0.99999994,-0.0012718431,-0.016733652,-0.08578526,-0.032131553,0.017937124,0.01130142,0.002760256,0.0050857607,0.059695948,0.02364299,0.04705879,0.009781469,-0.08715897,-0.039833806,0.01299387,0.016784221,-0.06419343,-0.012588882,-0.023118896,-0.02034682,0.17417519,-0.006262318,0.06738257,0.06265528,-0.030862391,-0.048337243,-0.014547821,-0.010595939,0.027486073,-0.10986676,0.032413896,0.0058628013,-0.016054166,-0.038161926,0.029762698,0.024586774,0.004938185,-0.027248736,0.06180542,0.019884445,0.038442627,-0.06393106,-0.089040235,-0.011669381,-0.097251594,-0.06998636,-0.005983526,-0.023300719,0.073130414,0.057476472,-0.057376288,-0.05322059,-0.072135136,0.0058651827,0.03847094,-0.027769037,-0.034971725,-0.029330544,-0.015537066,-0.04406243,-0.01935424,0.0119012315,-0.009043107,0.006296193,-0.025712954,0.016890125,-0.021376759,-0.028818596,0.011414181,-0.061750785,-0.06906971,-0.062875405,0.021154381,0.050716456,-0.05887271,0.038404193,0.041998364,0.06822916,0.056628898,-0.07310826,0.043020844,0.073037446,0.049397353,0.109052554,0.03323574,0.011498739,0.057559974,0.0142811835,0.13566142,0.014731564,0.0268918,0.017475806,0.005464868,0.0056964783,-0.018450975,0.014761401,0.08665544,-0.046327516,0.018979656,-0.016928537,0.047128562,-0.005524502,0.014057856,-0.14363614,-0.0803051,0.06818738,-0.13359396,0.07683454,0.032776095,-0.032138273,0.007639789,0.023290154,0.026890319,0.08215223,-0.03554466,0.1255341,-0.017456386,-0.08240558,-0.09594072,-0.09675684,-0.009610275,-0.04011033,0.020010242,0.009221216,-0.02722759,0.0039737737,-0.036374856,-1.5746981e-33,0.0414303,0.017963985,-0.037997633,-0.08623399,0.02596828,-0.04027025,-0.016980004,0.05000942,-0.13642411,0.0005334115,-0.1095438,-0.083885595,-0.054470547,0.001470189,0.0071792165,-0.0053159753,-0.022869807,0.026694436,-0.011023112,-0.005674756,-0.008496517,0.06827344,0.0072020516,-0.04623094,-0.034940764,0.103601985,-0.02470475,-0.022446396,-0.0035957166,-0.0006429065,0.020641001,-0.10722196,-0.016033204,0.018660817,0.011733567,0.04088968,-0.012243481,-0.048687104,-0.011491817,0.014268362,0.03334646,0.059091352,0.067796126,-0.0395795,-0.0064113317,-0.039805297,0.012650823,0.022558285,0.08993146,0.047616236,-0.0227278,0.025980923,0.06172355,0.019474097,-0.0804526,0.029948452,-0.026415482,0.0066382363,-0.0050978726,0.0022671202,0.023527188,0.005432766,-0.010776254,0.037404545,-0.033480994,0.027257271,-0.06729619,0.00953572,0.016124353,0.1175207,-0.059071723,-0.015190522,0.0064314664,-0.020158187,0.071469136,-0.03411154,0.016274676,-0.028904745,-0.021311259,0.059091795,-0.029097928,0.06489943,-0.05666875,0.038383327,-0.0565343,-0.017767346,-0.004267723,0.050026294,-0.07181762,0.048203632,0.023214364,-0.06492054,0.0009612872,0.028756272,-0.02295843,-3.1179845e-34,0.07734911,-0.10685719,0.044136465,-0.07633653,-0.05961678,0.07752484,0.023816656,-0.03644575,-0.011503729,0.017133506,0.024526179,0.056966074,0.04268171,-0.020231083,-0.02452488,-0.035453264,0.09016371,0.06729978,-0.048926357,-0.055333223,0.020984352,0.12802693,0.014741791,0.04628896,-0.009607832,-0.002764939,0.0794811,0.0799014,0.0072614197,0.041509904,0.04906256,0.021683771,-0.0600766,-0.011177657,0.009725616,0.0320846,-0.022409964,-0.014852857,0.024716629,0.042578645,-0.04181223,0.0066966307,0.0125067625,-0.0043200194,0.0397102,-0.0027014208,-0.10427136,0.00983187,-0.062102582,0.03787299,0.09363894,0.04993535,-0.015967842,-0.00276284,-0.016381748,0.0513059,-0.017013932,-0.009796131,-0.013293019,-0.044647552,-0.10867499,-0.016975773,0.022540247,-0.0021822073,-0.015983287,0.050034933,-0.0049744057,-0.006578714,0.10088747,-0.0038648495,0.054739155,0.057038765,-0.06892564,0.07142203,0.01474843,0.0019734846,-0.04434245,-0.08061622,0.033495735,-0.04069557,0.029417902,0.0047590556,0.042184245,-0.10537514,-0.022695221,-0.006295173,0.016576726,0.122820936,0.06724646,0.01661701,0.04080032,-0.097099036,-0.022283245,0.036563087,0.051102497,-2.4185361e-08,-0.04892671,-0.01443424,0.017406205,0.037102897,-0.054181043,0.022687461,-0.0044884183,0.011546693,-0.016692154,-0.073219806,0.070168406,0.07506411,-0.006717945,0.044195574,-0.0024344719,0.014912723,-0.0040122643,0.06904266,-0.03845904,-0.062344585,-0.064268835,-0.025570713,-0.10977505,0.097598925,0.011846629,-0.051956516,0.005852512,0.026633086,0.01868513,-0.006459507,0.036451634,0.03115889,-0.06920554,-0.016607648,-0.032665975,0.040532704,-0.013236759,0.004156439,0.051831406,0.040824767,0.041015282,-0.07736953,-0.036446355,-0.012904524,-0.043922532,0.033557847,-0.018699165,-0.028617352,-0.012568172,-0.017970772,0.07785233,-0.013351318,-0.024474168,-0.0740728,-0.13995332,-0.023000583,-0.032204833,-0.07106157,-0.026757708,-0.08512003,0.072286434,-0.019144995,0.20908052,-0.030627653 +2.3.1.322,Isolated from the plant Alstonia scholaris (blackboard tree).,384,1.0,-0.00879654,-0.011292468,-0.11466088,0.016266989,0.05227568,0.02260103,-0.034641005,-0.018660972,0.040763896,0.014864145,0.10260946,-0.02462206,-0.05464455,-0.043983012,-0.16026543,0.0553877,-0.051204674,-0.03196472,-0.013472835,0.044514865,0.040458977,0.119456604,-0.006246447,-0.00018726842,-0.0316288,-0.011625533,-0.080815904,0.03997781,0.047013126,-0.102082826,-0.03202843,0.01330642,0.07726524,-0.005393462,0.05704879,0.054658495,-0.03574409,-0.046774607,0.07661241,0.045488916,0.025203984,0.01707944,0.038107853,-0.008828862,-0.071525484,0.02494909,-0.082809255,-0.028055372,0.067284755,-0.0030841469,-0.0082878815,-0.088122144,-0.045657907,0.02359107,-0.047014587,-0.010768359,0.037686963,0.000976256,0.032198414,0.03996421,0.09456695,0.06983075,-0.012212039,-0.0007881576,-0.031915277,0.07111802,-0.09150379,-0.0258585,0.093822576,-0.03491239,0.06473022,-0.013369594,-0.0078326855,0.012370041,-0.014144568,0.027723335,0.02114855,-0.025168518,0.04259325,0.047051676,-0.01694769,0.071997374,0.018908521,-0.011467899,-0.0010266689,0.011548972,-0.009007525,0.110075,-0.03758598,-0.058977313,-0.014638422,0.038579497,-0.014463506,-0.07614264,-0.023455337,0.013606855,0.031047704,-0.04932654,0.004200264,0.028401745,-0.036812782,-0.034647383,0.10516455,-0.13011383,-0.11565162,-0.0012091817,-0.06312926,-0.063665025,0.10330689,-0.03583283,-0.07624679,-0.0048313453,-0.08481229,0.046123043,-0.0020189083,-0.0027160966,0.09626314,-0.01842578,-0.019639542,0.025281057,-0.023465898,-0.009024253,0.115920395,-0.0023932816,-0.00033162616,0.011854819,-0.10186988,-1.7504975e-33,0.041221205,-0.027227601,-0.010267669,-0.06881771,0.13046266,-0.04934175,0.03109894,-0.017706407,-0.06758405,-0.0051077153,-0.11193383,-0.055194683,0.014352969,-0.018738167,0.03065571,-0.017979618,0.0080309855,-0.021315983,-0.00046241298,-0.0042521385,0.038516883,0.06910148,-0.008655331,-0.033152215,0.012470328,-0.053840376,-0.020211881,-0.019430945,0.13613722,-0.010293093,0.028642945,-0.116905354,-0.066268384,-0.05353806,0.0395589,0.07301026,-0.026411751,-0.053594075,-0.016168045,0.04151296,0.0075810356,0.007994356,0.082979344,0.016514564,0.043514278,-0.003498656,-0.04079103,0.013810939,0.09073644,-0.080266945,-0.044454593,0.008296757,0.05549456,-0.041848224,-0.036902934,-0.028775953,0.0044210535,0.10978231,0.059355274,0.026745344,0.08193145,0.040846393,-0.0054638856,-0.008322344,0.061470132,0.06976988,-0.11523839,0.010331404,-0.032556634,-0.10056114,-0.032600697,-0.062632136,-0.03202575,-0.081446454,-0.034044895,0.01998777,0.011110806,-0.010168422,-0.027766682,-0.01090478,-0.07602711,0.012863545,0.022781795,0.013034142,-0.022335585,-0.012466395,-0.03496988,0.05958443,-0.028553719,0.00028775466,0.022908488,0.0025280456,-0.10918045,-0.02653846,0.06510736,-4.3822117e-34,0.03051142,-0.038232464,0.041224416,0.0031030567,-0.0449816,0.12883472,-0.07169864,0.06974508,-0.02612559,-0.024650758,0.029537698,0.058011696,0.034633182,-0.030639643,0.02333897,0.059692267,0.04508971,0.17136651,-0.031211015,-0.04664001,-0.0126681775,0.08821053,0.010169409,-0.06968596,-0.014153789,-0.01687346,0.030372204,0.042590566,-0.04603026,-0.011440697,0.020771347,0.015145934,-0.057024095,-0.067110784,-0.073262855,-0.037037797,-0.09366449,-0.13734327,0.0009644709,0.022192841,0.033925302,0.023350338,0.05358078,0.085835695,0.07874748,0.009869052,-0.040695824,0.02201983,0.0115119,0.027673004,0.018007109,-0.039425172,0.023988731,-0.01740045,0.041170154,-0.007915373,0.039622232,0.05149853,0.0015586024,-0.00900711,0.028333891,-0.042973056,-0.09234982,-0.0027393536,0.051913377,0.082032055,-0.026112475,-0.0029011923,-0.023245873,-0.038706828,-0.003855988,0.058060724,-0.012862338,0.1031056,0.027486961,0.081127755,-0.029416868,-0.01996408,0.019633215,-0.0131469285,0.0013821779,-0.030048907,0.037283413,-0.047437105,0.07944446,-0.060292374,0.05647477,-0.0076658917,0.01757362,-0.049955584,0.007979578,0.047820568,-0.054402158,0.024011724,0.06862893,-1.7944236e-08,0.069205046,0.02314943,0.03070546,-0.061072968,-0.025784053,-0.05139258,0.05195752,0.012789371,0.009576198,-0.01633967,-0.05395457,-0.049911052,-0.018698493,-0.025459299,0.042852968,-0.017517062,0.08549782,0.07490531,0.009869714,0.013954207,-0.022012586,-0.030679975,0.059897717,0.03705313,-0.07185061,-0.09210985,0.08594136,-0.0014319926,-0.007625726,-0.050058745,0.033329025,0.101699136,-0.039104853,-0.028442023,-0.03240046,0.067958504,-0.041595597,0.008704128,-0.043017928,0.0076642423,-0.0020860229,-0.058574386,-0.035806783,-0.042592734,-0.0376222,0.0017118655,0.023217285,0.040802408,0.012728248,-0.02588681,0.020796567,0.0153235765,0.039981965,-0.0070019416,-0.056660626,-0.04445043,0.055954676,-0.03703241,-0.019779634,-0.02547382,-0.02456664,-0.047664907,0.08021512,0.053063855 +2.3.1.323,"The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs.",384,0.99999994,-0.004602426,0.017858366,-0.13861106,-0.0020473625,-0.039494313,0.06845328,-0.027397573,0.058417514,0.10215341,-0.012826529,-0.0045013963,0.023773003,0.008910501,-0.030739091,-0.109436214,0.085463725,-0.068308875,0.027429711,-0.008818759,-0.034295026,0.013057957,0.05209139,0.050509464,0.04921409,0.025959784,0.02314105,-0.050206766,0.017825596,-0.0030465412,-0.010709178,0.0585095,0.039998062,-0.001313003,-0.0223834,-0.05722223,0.023395525,-0.081099115,0.030798092,0.01963576,0.09095356,0.03338899,-0.03358406,-0.050970998,0.023033598,0.0024887333,-0.0624103,-0.022928411,0.004347688,0.059781145,-0.024023408,-0.013300684,-0.061153546,-0.063182354,0.0021483954,-0.036378305,-0.110865176,0.01844056,0.062597655,-0.022659853,0.055020645,0.08118351,0.014108693,0.023513464,0.05234627,-0.051359385,-0.065381065,-0.05821414,0.00039689188,0.02034347,-0.09008032,-0.008751562,-0.078167625,-0.018719994,-0.057153042,-0.05738616,0.027537812,0.016625283,0.031491052,-0.023251466,-0.06083092,0.027530069,0.02237615,0.030133693,0.113661736,0.06048335,0.08789909,0.033963695,0.021349037,0.06775812,-0.010602563,0.060522374,-0.010296668,-0.045770086,-0.0074893213,-0.10204111,0.023361977,0.020845482,-0.03128482,-0.044042222,0.015024545,0.007512712,-0.030994017,-0.09493789,-0.054152843,-0.08483408,0.045313824,-0.05581946,-0.0032058007,0.013679451,-0.0318837,0.02137068,-0.0045553,-0.032604292,0.032113317,0.018473428,0.068274386,0.058416888,-0.03917292,0.011491812,0.014068436,-0.110851705,-0.030062413,0.010583197,0.033996206,0.012975809,0.01760408,-0.03576567,2.6141475e-33,0.054318625,0.057675567,-0.03309691,-0.025108974,0.01697707,-0.028194275,-0.10772326,0.0439548,-0.056349866,-0.07038547,-0.07617495,0.020933395,0.008864955,0.051266853,0.012855878,-0.011109477,0.024629679,0.0013938464,0.055142894,-0.060693532,-0.004395036,-0.019920947,-0.0740528,-0.007235628,-0.011012225,0.09253681,0.024944628,0.020059751,-0.00674754,-0.022276577,-0.003226513,-0.10925843,-0.02996692,-0.013212202,-0.0029917755,-0.010616059,-0.011792496,-0.012553734,-0.030219518,0.07894991,-0.009400356,0.02802521,0.023617545,0.015550387,0.112821855,4.2177686e-05,-0.043986563,0.1504123,0.055382263,0.02675446,-0.015788065,0.023946088,0.1250709,0.044600554,-0.111092694,0.045292147,0.003440818,0.020816892,0.023300659,0.043996472,0.011436881,0.011125419,-0.04733374,0.031895746,-0.0036647115,0.009541328,-0.026029052,-0.046480104,0.060188446,0.0803408,-0.09556926,0.031367622,0.03631027,0.024876727,0.06571524,-0.009328411,-0.0037314224,0.05290583,0.02961421,0.057747025,-0.054185424,-0.07949748,-0.0017010206,-0.005579729,-0.0654873,0.013198652,-0.016528785,-0.059076093,-0.029461963,0.04200158,-0.005464096,0.0033395155,-0.075721465,0.01681345,0.04805677,-3.1193113e-33,0.06171558,-0.07409655,0.0529108,-0.04650597,-0.01128797,0.07401807,-0.0648098,-0.021320958,0.030291932,0.011146562,0.02249058,-0.0044233506,0.089496136,0.004548664,-0.030733231,-0.055763617,0.032208916,0.10500028,-0.034421403,-0.037992414,-0.096099384,0.12330767,-0.04037497,0.03392496,0.0067875423,-0.05272945,0.01358036,-0.020237459,-0.031381484,0.08220709,0.06948005,-0.013262771,-0.059522025,-0.029387778,-0.060304523,0.09595556,-0.029970722,0.020856496,0.0023679396,0.06992808,0.04282826,-0.011577642,-0.016573936,0.07324707,0.024502847,0.0020579693,-0.12408189,0.12789176,-0.004744512,-0.03774261,0.036450915,0.025870346,0.06638889,0.009240564,0.07629587,-0.01569511,-0.022718864,-0.07618155,-0.015813801,-0.023360332,-0.009631616,-0.0694736,0.005404853,-0.021358084,-0.02988387,0.0486954,-0.015609322,-0.007736214,0.08245554,-0.0131846145,0.08006204,0.0010775573,-0.02210664,0.07673246,-0.0663204,0.019266337,0.0026939157,-0.091378376,0.022874512,-0.0041328836,-0.04680434,-0.016374184,0.03132927,-0.08955124,-0.0498594,-0.0031568347,-0.008301053,0.0750061,-0.008669145,-0.004247325,0.019147431,0.05276065,-0.08462708,-0.017463839,0.04169748,-3.710253e-08,0.07312784,-0.035121873,0.04052776,0.017944893,-0.036351115,-0.034885716,0.042501822,-0.0021800098,0.006069675,0.00044442146,-0.026263125,0.09111146,-0.034444276,0.026228407,0.047947988,0.039939683,0.13472773,0.0062304577,-0.019376023,0.036999527,-0.043612983,1.232125e-05,-0.026093932,-0.081911825,-0.0008280784,-0.1326845,0.0010100104,0.00046554644,0.029563611,0.0109289335,0.061023854,-0.011116967,0.00026880822,-0.048483904,-0.041130245,0.088788554,0.006846114,-0.028964236,0.045924965,0.00016740331,0.010365554,-0.0558965,-0.0020082663,-0.018574888,-0.09609304,0.0052935267,0.03881132,0.008379817,-0.021150598,-0.07328514,0.013702368,0.008074262,0.041626,-0.088792026,-0.13701282,0.012229106,-0.015812092,-0.07446897,0.006877263,-0.10956649,-0.005567901,-0.03638175,0.20982753,-0.029442143 +2.4.1.398,"Requires Mn2+. The enzyme, characterized from the flilamentous fungi Aspergillus nidulans and Aspergillus fumigatus, participates in the synthesis of fungal-type galactomannan and O-mannose-type galactomannan, which are embedded in the fungal cell walls. While the reaction shown here describes the transfer of one galactofuransyl residue, the enzyme can add up to 5 more galactofuranosyl residues.",384,1.0,0.020806022,-0.07558894,-0.09138233,0.013914168,0.13610394,-0.013743925,-0.018234525,0.0520119,-0.015307393,-0.0027130644,0.0879757,-0.042049415,-0.009529026,0.040100414,-0.1059098,0.021516295,-0.0327713,0.026863344,0.02983438,0.06836193,0.1518112,0.018017324,0.01622731,-0.04089733,0.1019279,0.0041357046,0.023337191,-0.08969091,-0.021337414,-0.09871863,-0.005842699,0.0071541225,0.08631094,-0.06554467,0.0049538547,0.058919396,0.026499392,0.008940685,0.027107697,-0.025253173,-0.048414778,-0.02227962,0.09314935,-0.07439841,-0.020354444,-0.0058343825,0.017296677,-0.00050795,0.018906245,0.040645715,-0.008911308,-0.04898641,-0.019936377,-0.010644042,0.05201644,0.07113044,-0.058490615,-0.090157546,-0.0123138465,0.02089562,0.061790828,0.047506616,-0.02176462,-0.019840516,0.02655831,-0.05725574,-0.006887778,-0.052673325,-0.0007301262,-0.03221054,0.016427886,-0.02132163,-0.048692677,-0.045399785,0.06684404,0.07664779,0.01801059,-0.01159385,0.091936275,0.0041471506,0.022335045,-0.012783201,0.06988333,-0.0064346786,0.024333417,0.01979955,0.060721837,0.048565783,0.006515224,0.029545618,0.03748047,0.025337527,-0.01820484,0.01834653,-0.045658514,0.034763176,0.007958124,0.066552565,0.037242167,0.0049561313,0.008649767,-0.027935322,0.028424613,-0.033578947,0.040118195,-0.019728709,0.019380512,0.0545828,0.056098875,0.0038443066,0.08024712,0.012209299,-0.02103451,-0.052884538,-0.011866089,0.052121583,0.027489021,-0.07298567,-0.09782912,-0.010659014,0.07042479,0.06474385,-0.05062422,-0.0064796316,-0.023663027,0.061739996,-0.020648614,5.2117967e-33,0.046763342,0.09957402,-0.011013625,-0.037977025,0.055478275,-0.0030597022,-0.033130314,-0.061854057,0.043570124,-0.054593347,-0.1157941,-0.031536773,-0.04884201,0.046381347,-0.040245138,-0.026952729,0.047166567,-0.057727195,0.093896404,0.021636598,0.0026637895,0.096392445,-0.08271171,0.009164755,0.066324726,0.024304425,0.08073121,-0.0060316822,0.081255525,0.007231889,0.036765732,-0.10833734,-0.0844998,0.01928807,0.071845226,0.020715814,-0.0316456,-0.08184559,0.003192157,-0.087267995,0.00269882,0.031263605,-0.12808965,0.052349877,0.0017884974,-0.05776506,-0.008746791,0.07866178,0.02147096,0.009937858,0.002090346,0.014459181,-0.018865814,0.073072664,-0.009976094,0.032983445,-0.049813244,-0.00671915,0.051374488,0.07526315,-0.022811085,0.013232691,0.018910538,0.10893608,0.054985497,-0.02430949,-0.021554265,-0.028359184,0.013128056,-0.005433216,-0.047693543,-0.13371088,0.021610737,0.03006011,-0.06324483,-0.062370863,-0.025887672,-0.03296414,0.008107846,-0.039461035,-0.0011375016,0.040615175,0.012174586,-0.0596468,-0.0861804,0.043604705,-0.05776255,-0.07014099,0.001455297,0.030597074,0.012859003,-0.040471807,-0.030644206,0.01733107,0.000842804,-5.868112e-33,0.09842347,-0.07333814,0.082787134,-0.035965823,-0.089724444,0.06902627,0.02543408,-0.06822895,-0.0015581488,-0.05131325,0.02089126,-0.022443986,0.023943063,-0.05676837,-0.0064635016,-0.007109077,0.07584345,0.104865365,0.0057018977,0.016687676,-0.00030524877,0.112528205,0.0012123932,0.020095099,-0.019344198,0.00812669,-0.004700527,-0.0041617085,-0.040967844,0.04993283,-0.01441768,-0.03134211,-0.033736423,-0.08243265,-0.0028952342,0.002523559,-0.026448356,0.0065435376,-0.0033725877,0.019219693,-0.0025843508,-0.0027732078,0.015103725,0.051827792,0.01589067,-0.0020774512,-0.08859826,0.0016443033,0.04257357,-0.088573426,-0.020725884,-0.019119585,-0.057148825,-0.023051599,-0.0029448501,-0.038170766,0.07257292,0.0026822248,0.07994103,-0.032287676,-0.031178487,-0.052972514,0.019058734,-0.071840905,0.09214376,0.04525773,0.00079411117,0.009746368,0.04919654,-0.050035153,0.036359884,0.037668806,0.04392759,0.075987644,-0.008129324,-0.013425885,-0.05878659,-0.0055696005,-0.0013627391,-0.05800536,0.07768189,0.011299377,0.069019996,-0.05040537,-0.013322764,-0.102618895,0.11108853,0.13855092,-0.087101474,0.00993493,-0.05531207,-0.016920423,-0.040210932,-0.001888263,0.07132849,-3.9359115e-08,-0.010097147,-0.02767127,0.02680818,-0.14898469,-0.0618861,0.010367477,0.0048059607,-0.028613891,0.025041461,-0.0738388,-0.017487807,0.14167331,-0.010808208,0.027047345,0.017647019,-0.014704269,0.012853396,0.051753696,-0.0451522,-0.02235827,-0.06683863,0.02176873,-0.10633743,0.0015231012,-0.028680969,0.048844095,0.04421466,0.091281995,0.017532041,0.009221186,0.03699792,0.015546076,-0.0022923497,-0.0492545,-0.091840915,0.049812086,-0.01947437,-0.05661781,0.021320699,-0.0036945404,-0.065886766,-0.005304311,0.018058132,-0.0028033857,-0.10443159,-0.06487376,-0.028700667,0.05993596,-0.04781295,0.077230126,0.0017556902,-0.07404259,-0.0631419,-0.07187545,-0.055622872,-0.027729817,0.033563856,-0.03151172,-0.041680988,-0.032647178,0.0017088067,-0.04925858,0.11656043,-0.029024893 +2.5.1.160,"A pyridoxal 5'-phosphate-dependent enzyme, found in plants, that participates in the plant L-methionine biosynthetic pathway. It differs from its bacterial counterpart, EC 2.5.1.48, cystathionine gamma-synthase, in being specific for O-phospho-L-homoserine (the bacterial enzyme is specific for O-succinyl-L-homoserine).",384,1.0,-0.09803582,-0.057388473,-0.06008549,-0.012602304,0.07383673,0.10015019,-0.0797687,0.057603117,0.06012178,0.014841189,0.07639257,-0.0183332,-0.007326324,0.01790983,-0.074039534,0.050766867,-0.095545314,-0.00833099,0.0047310996,-0.025763478,0.07231918,0.09162899,-0.024005236,0.012312439,0.052671675,0.006561977,-0.008209738,0.0545794,-0.017280577,-0.032621372,-0.037556853,0.019124595,0.04990807,-0.055963382,0.07602992,0.10699276,-0.028703043,-0.047958497,0.081650354,0.02843154,0.050198976,-0.036368687,0.009908781,-0.010271722,-0.022108993,0.02172364,0.014465245,0.0028336926,-0.016813355,-0.13032737,-0.11652924,-0.042224173,-0.048341006,-0.013760761,-0.020957474,0.027677963,0.023689272,0.010659297,-0.01954475,-0.025866503,0.022922767,0.013813855,0.0075349696,0.0010939084,0.002438921,-0.02137369,-0.035706516,-0.09931956,0.028141862,-0.034247648,-0.07327226,-0.05768244,0.045323808,0.027763894,-0.05522461,0.04237666,-0.021868335,-0.011435558,-0.018428335,-0.057086926,0.04754373,-0.020649444,-0.049177628,0.02804464,0.021912001,-0.01964272,0.013031456,0.05538816,0.08821316,-0.043016523,-0.008636706,-0.031525336,-0.021501148,-0.046376005,-0.09549935,0.032189667,0.016344557,0.001346241,0.007984894,-0.03561346,-0.0049165688,0.031488188,-0.06941045,-0.030208211,-0.08439459,-0.018690798,0.0068945303,-0.0011220996,0.015929682,-0.03273118,-0.0023124362,-0.0014383806,-0.027340516,-0.011631393,-0.028023895,0.046474367,0.07442916,-0.039443042,-0.056788795,0.02863499,0.026722288,-0.106960915,0.044489484,0.05774488,-0.018448625,0.04071114,-0.12225898,4.0212275e-34,0.08583323,0.07495638,0.009851736,-0.02282481,0.06541215,-0.012478176,-0.06303585,-0.05939141,-0.051881198,-0.08139116,-0.05646585,-0.02896798,-0.0048963,0.020336818,-0.0226406,0.0046451017,-0.07708805,0.03277942,0.05335812,-0.010084422,0.030340072,0.02118915,-0.059681825,0.07393265,0.026482739,0.048591353,0.027933454,-0.02351562,0.03243819,-0.01397874,0.014636442,-0.04555906,-0.019405266,0.018425476,0.067155376,-0.0510173,-0.11428832,-0.075910784,0.038935408,0.02734845,-0.0359416,0.013207606,0.035228506,0.02188532,0.050211377,-0.01175004,-0.10240437,0.08203084,0.02784156,0.056343455,0.01602883,-0.01569341,0.10606351,-0.019329762,-0.066925794,-0.031986125,-0.030302202,-0.0053908415,0.034708496,0.0634654,0.033960856,0.06333939,-0.044134177,0.02867699,-0.016458955,0.02889076,-0.023255747,-0.07319865,0.09211478,0.13665757,-0.022221137,-0.05326013,0.032136697,0.103759885,0.031977065,-0.022672858,-0.06570593,0.025914367,-0.01516524,0.011943079,0.008408677,-0.06624993,-0.024813551,-0.029454459,-0.030844882,0.0047960295,-0.03490127,-0.034783784,0.001977216,0.020723017,0.08854341,-0.09008777,0.0011428288,0.05050559,-0.018270204,-1.0233168e-33,0.045319796,-0.055278104,0.08770994,-0.05396808,-0.0427016,0.024688838,-0.03737467,-0.046274792,0.061347686,0.002957626,0.04874374,0.03153584,0.036574785,0.00776194,0.005513419,-0.021311572,0.051062632,0.058738366,0.01267048,0.050165944,0.047440834,0.032828078,-0.007117958,0.008154949,0.09403634,0.030792974,-0.0012482753,0.07734175,-0.03540206,-0.014659722,-0.039029203,0.02777979,-0.03156331,-0.101745814,-0.036497723,0.021430295,-0.05532522,-0.00910191,0.030941637,0.059420865,0.03208583,0.04932992,0.0861174,0.03475446,0.013500009,0.043631278,-0.065137476,0.0022889648,-0.016995594,-0.03287375,0.0025047488,0.017506767,0.00020724162,-0.0071066585,0.012267862,0.018015027,-0.04801766,0.050161313,-0.07153921,-0.021393023,0.027013721,-0.11873326,0.002905575,0.09356788,0.027583512,0.09347112,0.06594312,0.041289862,0.027808493,0.01567348,0.03318344,-0.02553648,0.046526153,0.08467822,-0.07924739,-0.007062615,-0.07386477,0.010245907,0.01650825,0.0165281,-0.012974648,-0.02640749,-0.012562652,-0.07150496,-0.030453414,-0.07301095,0.037479684,0.13790417,0.07467655,0.042450026,-0.05118207,0.027418746,-0.040039666,0.006461119,0.11910978,-4.1862425e-08,0.060114842,-0.11007926,0.04095852,-0.029810427,0.045328457,-0.05443675,0.009630922,-0.029948313,0.11913426,0.020356927,-0.012454036,0.05999703,0.03139058,-0.029205456,0.023256995,0.057080243,-0.008349755,0.032912824,-0.0013631843,0.049385443,-0.051068775,0.022368774,-0.111095205,0.035446685,0.03807361,-0.08297402,-0.004201707,0.048663765,-0.057861447,-0.054207154,0.08091722,0.01986022,0.0404684,-0.057209622,-0.13678421,0.014818835,-0.0748242,-0.06026139,-0.013069106,0.015298321,-0.0014786618,-0.022191077,-0.04023713,0.027737498,-0.0023236978,0.055693097,-0.022352604,-0.048280112,-0.019374417,-0.0015169209,0.026763907,-0.004526932,0.024185883,-0.12457887,-0.099772364,0.014674167,0.056160524,-0.0016684474,-0.027546877,-0.06790577,-0.01715233,0.008715283,0.21093215,-0.034388095 +2.7.11.38,"This enzyme is found in animals and choanoflagellates, although it has been lost in arthropods and nematodes. It is implicated in centrosome separation [1] and cilium formation [6]. In peptide arrays, the enzyme prefers to phosphorylate Ser, with acidic residues at -2 and -4/-5, similar to that of the NEK6 protein kinase subfamily [4]. NEK9 can autophosphorylate. Substrates in humans include the microtubule-associated protein kinases NEK6/7 [1], the microtubule-associated protein spindle assembly protein TPX2 [3], the gamma-tubulin associated protein NEDD1, which is required for mitotic spindle assembly and function [2] and the LC3B protein, which is involved in autophagy substrate selection and autophagosome biogenesis [5].",384,1.0,-0.072275594,-0.06608537,-0.06686417,-0.11360542,0.061685193,0.014544736,-0.0288788,0.02117281,-0.0104116155,0.017480668,0.0059607197,0.013566932,-0.04258265,0.058094274,-0.055545826,0.044457443,-0.08025903,-0.014758065,-0.012168246,-0.06054982,-0.0044581788,0.021042947,-0.024487533,0.023323223,0.01495776,-0.08895087,0.013848798,-0.041231353,-0.009272875,-0.020956852,-0.087075904,0.0072606364,-0.08081879,-0.025027065,0.0228777,0.04214143,-0.09154223,-0.052275132,-0.053805992,-0.13084407,0.154818,-0.0528115,-0.005866293,-0.038421452,-0.013568555,0.089971684,-0.00022153604,-0.0027001472,0.097685404,-0.008888073,-0.10234588,-0.06619906,-0.003564941,0.061266012,-0.01565217,0.08208029,-0.060185302,-0.009774661,0.047099937,0.07422482,-0.054332573,0.0030297632,0.0973429,0.017328167,0.1101792,-0.0056828945,-0.043412726,-0.02000364,-0.041888658,0.03398935,-0.012889962,-0.059051998,-0.018171875,0.046270333,0.007878379,0.11365724,-0.07421874,-0.022398744,0.003264094,0.005327049,-0.07574903,0.049616892,0.09780349,0.1043955,-0.009542691,0.016253345,-0.01642475,0.069511384,-0.015704228,0.00014060171,-0.017843084,0.030204289,0.017318746,-0.027462289,0.028224556,0.03284567,0.023497537,0.033058744,-0.045699503,-0.0040090736,0.024275288,0.07291602,0.052298594,-0.010260147,-0.050603766,-0.00080792827,-0.009367963,0.026319806,0.025861539,0.023126002,-0.01959048,0.032235704,0.040550236,0.0061217397,0.015359433,0.045633297,0.026746035,-0.046620477,0.08801965,-0.020366695,0.014602083,-0.024501944,-0.01836694,0.009338058,0.019094931,0.056726106,-0.12638725,1.78298e-33,-0.039764807,-0.041911278,0.04675362,0.019934516,0.0018747551,-0.030234294,-0.07762696,-0.07242099,0.0029412662,-0.033456746,-0.06161767,-0.034997486,0.04651002,-0.0313085,-0.1171895,-0.036047485,0.032606132,0.01236382,0.039044496,0.024169954,0.033230443,0.07200751,-0.038261212,-0.038250145,0.0017665251,-0.001551153,-0.071678616,-0.026768813,-0.050787408,0.018201662,-0.05961834,-0.008036176,-0.10665642,0.04932606,0.0380959,0.01598721,-0.05528761,-0.073819466,-0.06217531,0.05211622,0.0592522,0.0023446805,-0.039239682,-0.045521516,-0.023905538,-0.058149423,0.021770181,0.06928667,0.002356934,-0.054082423,0.054217324,-0.013077766,0.044943854,-0.00059789565,-0.029852912,0.023276914,-0.053938683,-0.04333848,0.025567628,0.005516668,0.01377655,-0.040549677,-0.06032278,0.10608425,0.08840213,-0.008383846,-0.07607723,-0.04035844,-0.024763344,0.015150136,-0.030126866,0.0047205207,0.08427073,0.01655706,0.0124965245,-0.052081775,0.015213648,-0.027811863,-0.071404055,0.023336008,0.10439795,-0.040662076,-0.03990114,-0.04669196,-0.047738172,0.008072479,0.054770604,-0.0067404597,-0.0143742245,-0.022747979,0.09821271,-0.014114462,-0.014220606,0.1041838,-0.086786926,-3.1999605e-33,0.014251901,-0.083530664,0.068507604,-0.011677382,-0.01740229,0.09210496,0.14631298,-0.07341502,0.05785854,-0.038509797,0.027485058,0.021674085,0.06604965,-0.08080042,0.0126399025,0.030215502,0.006539318,0.036311004,0.09065173,-0.05934587,-0.030429866,0.063532785,0.011120335,0.07770004,0.0024069382,0.027043914,-0.01817819,0.041666254,-0.033767425,0.08019508,-0.058874905,0.072255306,0.017140854,-0.041410908,0.0064214133,-0.067599416,-0.07751416,-0.056141596,0.05962993,-0.032389104,0.03279643,0.07564737,-0.015202124,0.0057498515,-0.006960328,0.07535768,-0.006842908,0.1072854,-0.034627628,0.003565227,-0.013026182,0.0074506514,-0.026918931,-0.039738797,0.009526892,0.101175435,0.095087275,0.0761864,0.06585073,0.028691782,-0.046976175,0.0003492014,0.0031222573,0.07916783,0.04137059,0.06408309,-0.05800828,0.06696873,-0.042880464,0.06374215,-0.016237864,0.06477465,0.041930366,-0.011043457,0.024559569,-0.011781406,-0.00010590329,0.020218553,0.048451528,-0.06400217,-0.04356233,0.062680095,-0.03706184,-0.0075295083,-0.025781533,-0.016912248,-0.014844211,0.10359493,-0.007214023,-0.021955183,0.0092098415,-0.047492508,-0.12612411,0.0757353,0.052196346,-4.557152e-08,0.11322326,0.0061464394,-0.004153837,-0.026854074,-0.011578345,-0.041606374,0.058323164,0.07799136,0.01892408,0.038511224,0.012854012,0.001441514,0.006839036,-0.059798367,0.013744121,0.039819412,0.043521255,0.02159495,-0.05296149,-0.03196869,-0.004433233,-0.074480444,-0.01684345,0.0002778976,-0.025805812,-0.020728016,-0.027803913,0.118589364,0.003536206,-0.06893369,-0.089871064,0.01767755,-0.013569831,-0.05978946,-0.03865383,0.072566085,-0.099151276,-0.04981742,0.047349278,-0.015287443,-0.04745921,-0.004382568,0.04639351,-0.08084102,-0.06539701,0.020477487,0.04958333,0.015990602,0.0010865428,-0.0012330447,-0.0032867664,0.042356748,0.023669044,-0.028136842,-0.017267687,-0.012176802,-0.0016022521,-0.05742403,0.019858187,-0.06916187,-0.02815104,0.028341405,0.09956111,-0.0835526 +2.7.11.39,"Requires Mg2+. An animal specific kinase that is duplicated in vertebrates (ROCK1, ROCK2), and with homologs in Drosophila (rok) and Caenorhabditis elegans (let-502). They are ~1300 amino-acid proteins, with an N-terminal kinase domain, with the AGC-specific kinase domain tail, followed by a central coiled-coil region, HR1 domain, Rho-binding domain (RBD), and PH domain. The PH domain is split by an inserted CRD (cysteine-rich Zn finger motif). ROCK is activated by the small GTPase Rho and modulates the cytoskeleton by phosphorylation of a wide array of other cytoskeletal proteins. Binding of Rho-GTP to the RBD relieves an intramolecular inhibition and activates the kinase activity. These kinases modulate the cytoskeleton in response to Rho GTPase signalling. Substrates include LIM-kinase (LIMK) which phosphorylates and inhibits cofilin, blocking its actin-depolymerizing function [1], and myosin regulatory light chain (MRLC2/MYL12B) that regulates Myosin II. In Drosophila it is involved in the planar cell polarity pathway, where it is genetically downstream of frizzled and dishevelled gene families, and phosphorylates the non-muscle myosin light chain, regulating Myosin II [2]. It is activated by Rho1, the single homolog of human RhoA/B/C, which also activate ROCK.",384,1.0,-0.13296111,-0.06660993,0.07102578,-0.0014282204,0.07035147,-0.0075620473,0.016630128,0.0142515255,0.014567763,0.020812323,0.026181923,-0.02501654,0.026622377,0.04583352,-0.045973875,0.056383025,0.0030150185,0.0704524,-0.06810254,-0.026836963,0.056456946,0.057588317,-0.002648579,0.04850519,-0.06735052,-0.033829182,0.026716428,-0.014227067,-0.026646575,0.0070780627,-0.020315478,-0.041947357,0.0017108108,-0.022413574,-0.01767242,0.08568974,-0.083924934,-0.069034174,-0.024302302,-0.03541714,0.051006764,-0.03241872,0.06720704,-0.060922153,0.012549003,-0.034469496,0.031574234,-0.054465026,0.03590422,0.025918808,0.034423757,-0.011209699,-0.0495045,0.043854482,0.0104881,0.09705828,-0.13717516,0.025803551,0.042963237,-0.052786216,0.012770346,-0.036442954,0.031070665,-0.029052027,0.039417647,-0.031180222,-0.0075855507,-0.03469333,0.022489201,0.025668856,0.043015104,0.04587191,0.03453899,-0.026808657,0.019464448,0.054927398,-0.046823993,-0.012484407,-0.011170673,-0.05928426,0.0060623693,0.01700924,0.15118322,0.05062549,0.016566398,0.04829708,0.028751174,0.054727446,-0.075696915,0.009784215,0.101868495,0.009736875,-0.028382938,0.04969875,-0.02637187,-0.009231599,-0.022087123,-0.005258813,-0.122982346,-0.008052575,-0.020310866,0.07464698,0.038234863,-0.07742057,0.028625626,-0.056992207,-0.018481841,0.028076146,-0.041448966,0.014870159,0.06501602,0.014856272,0.06634907,0.079835825,0.043918896,0.028725097,-0.084231585,-0.011574483,0.06536443,-0.002646521,-0.03226569,0.008101227,-0.09899685,-0.052335024,-0.017688956,0.0023225292,-0.12558688,4.2382666e-33,0.022232741,0.01606106,-0.028256139,0.023654351,-0.016200252,0.01728358,-0.06795112,-0.050569236,0.0037031507,-0.016553855,-0.06746735,0.033154566,0.003649973,-0.017431378,-0.076616526,-0.034273587,-0.05892709,-0.047805343,0.050542124,0.0056826044,0.049475092,0.0028871587,-0.031158555,-0.025810262,0.034529928,-0.0022798397,-0.09351294,-0.073986396,0.0023887225,0.038648393,0.01969845,-0.025528515,-0.016272312,0.06332104,0.03773836,-0.010768363,-0.006267172,-0.086956464,-0.032417092,-0.013101852,-0.034241866,-0.036906656,-0.10477701,0.03417957,0.005030298,-0.059508093,0.020242967,0.10770139,-0.05837009,0.018776055,0.10810716,-0.01360265,0.06505167,0.023214128,-0.04598769,-0.090964414,-0.07330054,-0.09867403,-0.020591963,0.027083667,0.06617993,-0.025684007,0.004788029,0.11361526,0.09517219,0.052767836,-0.06555549,-0.058459666,-0.02634537,0.057403866,0.04620976,-0.01046185,0.08040638,0.042256,-0.0978746,-0.100223534,0.036438562,0.026044633,-0.07567065,0.15287025,-0.05301035,-0.04700113,-0.027622279,-0.044176027,-0.052289195,0.03049956,0.096289136,-0.041904863,0.04070986,-0.047690958,0.005874768,-0.07313087,-0.009598496,0.03302209,0.02531787,-4.5074537e-33,0.020614143,-0.029952126,0.08068573,-0.021777714,-0.06272811,0.09451819,0.12160396,-0.08655147,0.040898513,-0.10047168,0.027415864,0.087556966,-0.002237722,-0.030902706,0.07582402,-0.050649326,-0.05388496,0.010837544,0.027894577,-0.02674977,-0.055968273,0.03151157,-0.027817443,0.124817364,0.07031385,-0.006340057,-0.048990823,-0.008388232,-0.047873534,0.05367411,-0.0046640085,0.07345024,-0.061687037,-0.015177944,-0.04650613,0.01573274,-0.012512094,-0.05604074,-0.0013445319,-0.0014402575,0.049528282,-0.05214483,-0.01582131,0.077864654,-0.004179106,0.087554365,-0.016503792,0.09167789,-0.030475494,-0.046989895,-0.008826082,-0.007795338,0.0003058131,-0.041430864,0.073290735,0.032731127,-0.0023733207,0.016773058,0.014224286,-0.009666922,-0.040558096,-0.03158585,0.009600332,0.11839987,-0.023000317,0.07413275,0.04842497,0.004660621,0.008138615,0.08817787,0.018734988,0.07077447,0.065721706,-0.035877615,-0.051521957,0.053878278,-0.023068566,-0.017042222,-0.05142282,-0.07482039,0.009807442,0.009468538,0.01301398,-0.007337813,0.010956221,0.001062293,-0.023008326,0.079429865,0.011857368,-0.035487007,-0.012682215,-0.08402511,-0.04816965,0.045763966,-0.008813026,-5.0579626e-08,0.018525809,0.041606672,0.032311678,-0.081111036,-0.015047889,0.06931366,0.07439681,0.019868163,0.007988073,0.02558422,-0.04397651,-0.06557792,-0.0040943404,-0.03354721,0.020783236,0.07749638,0.015534546,0.07554751,-0.0050075264,-0.03867375,-0.008051852,-0.09080955,-0.034444537,0.05025661,0.0009382064,-0.036905993,0.06979273,0.024617245,-0.018094223,-0.014679883,0.09760874,-0.087414175,0.057085842,-0.01360414,-0.030558577,0.07147996,0.007775228,-0.012307255,-0.05671097,0.006132028,-0.055262893,0.030020453,0.051209535,-0.08602536,-0.112130225,-0.03466611,0.0741431,-0.017124692,0.0013882711,0.07051119,-0.03055499,0.05197524,0.020148998,-0.04091245,-0.049965404,0.039931618,0.036256183,-0.049806178,-0.013765707,-0.0033680908,-0.05057816,0.020646641,0.020209126,-0.049249854 +3.1.3.111,"The enzyme, studied from mycobacteria, in involved in the biosynthesis of trans,octacis-decaprenylphospho-beta-D-arabinofuranose, which serves in those organisms as the arabinofuranose donor for the biosynthesis of the cell wall polymers arabinogalactan and lipoarabinomannan.",384,0.99999994,-0.055824637,0.0045073978,-0.08439777,-0.050403554,-0.055390004,-0.010647526,-0.015088653,0.06887427,0.013926248,0.041637946,-0.029632892,-0.051779494,0.007893213,-0.0100678075,-0.05542395,0.05537947,-0.010866705,0.07997436,-0.01676957,-0.01024261,0.07405492,0.031235557,0.003157187,-0.0534575,0.061155252,0.0245091,0.017288182,0.027229572,-0.021479914,-0.041460056,0.013466967,-0.053137783,0.05956597,-0.053574983,0.09488467,0.1177409,-0.017279577,-0.0692118,0.13009404,0.013860177,0.10972833,-0.034058888,0.056895018,-0.041453984,0.009432136,0.018906668,-0.01642059,0.03211405,0.041208375,-0.048671663,-0.044413686,-0.014729811,-0.08170615,0.013695575,0.021826824,0.0022873937,0.029781807,-0.022394901,-0.011443343,0.027602986,0.034983575,0.03061394,0.03253244,0.054408293,-0.06278359,-0.051713094,-0.0007197438,-0.006633069,0.0464971,-0.03201988,-0.025460701,0.011898101,-0.0390593,0.035230283,0.02691561,-0.028217359,-0.029183289,-0.0441299,-0.0487022,0.016828023,0.016758423,-0.07264734,-0.0033505487,-0.040795457,-0.026074637,-0.053502515,0.10995269,0.03234156,0.01695664,0.1241247,0.05706725,-0.043010984,0.05720009,-0.08667064,-0.05801682,-0.045816842,0.073695675,-0.014362065,0.043667026,-0.03552425,-0.017494552,-0.07726008,0.02763247,-0.06586619,-0.07569703,-0.0001672992,-0.07616756,0.012955721,0.049390808,-0.0011019042,-0.06581048,0.0025781263,-0.0016974158,0.032211453,-0.004083915,0.098085575,0.018231776,-0.12291073,-0.0017225419,0.03713692,0.0033846009,-0.07021317,0.049780883,0.021958744,-0.09597398,0.074363425,-0.10732035,2.2274062e-33,0.005943895,-0.022204852,-0.021404557,-0.03786167,-0.019105148,-0.08008702,-0.06758837,-0.008452186,-0.07431745,-0.066087626,-0.075787574,-0.08503625,0.040764317,0.14561431,-0.10152231,0.0722994,-0.0066073807,-0.029058052,0.05726812,0.06147886,0.022681069,0.027662322,0.025335284,0.018042976,0.029801892,0.058573015,0.0022063875,-0.01293045,0.050309952,-0.0033515794,-0.0011596362,-0.040625647,-0.05153653,-0.02542408,0.07173446,0.029911814,-0.060706995,-0.08083405,-0.009789421,-0.0064175623,-0.004040732,-0.05545914,0.028232094,-0.005100456,0.08822184,0.049991086,-0.03819952,0.0203771,0.031588834,0.03662478,0.018732501,0.034483604,0.047533225,-0.03622657,-0.016671639,-0.037961073,-0.05435677,0.01285344,-0.009423823,0.010021196,-0.014993404,0.056031782,-0.017736143,0.05997256,-0.023353528,-0.009693081,-0.017244224,0.0026089929,-0.004155581,0.020058187,-0.02228496,-0.09326547,0.028922716,0.020212615,0.1040134,0.019566422,-0.04247502,-0.024453728,-0.0060770176,-0.052713547,0.0421247,0.060457982,-0.045302875,-0.08835612,-0.08595447,0.007838698,-0.00083581486,-0.0141497,-0.0124252755,-0.005007642,0.011682945,-0.07360983,-0.039811756,0.06185928,-0.02323832,-6.0648948e-33,0.0966812,-0.14330606,0.052036732,-0.05257333,0.0059280214,0.02025749,0.07290398,0.04056954,0.049738523,0.049246855,0.068898134,-0.049519375,0.03152474,-0.058680255,0.03674606,-0.0024597314,0.01578491,-0.007499847,-0.049777396,-0.040245134,-0.044340152,0.10246562,0.0002746499,-0.037336912,0.024628324,-0.031564888,-0.044939853,0.09996218,0.017766278,0.042362105,-0.02422443,-0.016920205,-0.06531766,-0.010020855,-0.05152283,0.070229016,-0.05843384,-0.0379924,0.037680034,-0.0027720276,0.03807436,0.06996849,0.014187774,0.037666947,0.0061919843,0.0011305307,-0.117921695,-0.0037340475,0.030251915,-0.09062009,-0.050489627,0.073777705,0.07012368,-0.008396497,0.060628448,0.06782548,0.029920999,0.04018803,-0.002620378,-0.031416368,-0.08126737,-0.11073513,0.1118864,-0.04274317,0.031242955,0.08346714,0.013124255,-0.04118112,0.008362392,-0.0351966,0.09508322,0.043551486,-0.069641374,0.061802987,-0.0025478203,-0.009267226,-0.088527866,-0.030543545,-0.08621983,-0.008264188,0.023638092,0.005094512,-0.035368327,-0.05870836,0.03614893,-0.06912626,0.04395137,0.10727532,-0.07331949,0.009746379,0.012811451,0.008652707,-0.092687994,0.0005495032,0.04537092,-3.8855717e-08,-0.0046910886,-0.03505752,0.10029216,-0.053930145,0.004044582,0.06975621,-0.014385239,0.004691082,0.001473579,-0.03332958,0.015329249,0.045803495,0.032693576,0.05958635,0.013337773,0.031750973,-0.059632424,-0.0429516,0.015845368,-0.054358706,-0.065290205,-0.0102509465,-0.10707861,0.04248676,0.0066847447,-0.010475981,0.022783674,0.06362717,-0.012112049,-0.00015898686,-0.00803546,0.010386539,-0.044238154,-0.06565308,-0.0537558,-0.014085462,-0.05830953,-0.0793653,-0.020816091,-0.007691854,0.092943266,0.0014176401,-0.052434564,0.03169051,0.0025900684,0.013566761,-0.015009881,0.01909145,-0.065519,0.08716624,0.08824776,-0.013010543,-0.08288002,-0.011256729,0.0051077832,-0.000852211,-0.031809952,-0.037507206,-0.052645985,0.03622035,0.01458596,0.002649751,0.17823203,-0.06329259 +3.1.3.112,"The enzyme can catalyse the sequential hydrolysis of tri-, di-, and mono-phosphorylated oxetanocin A compounds, releasing one molecule of inorganic phosphate at a time. The active site switches from a dinuclear to a mononuclear metal center as phosphates are eliminated from the substrate.",384,1.0,-0.104565635,-0.040339183,-0.020189904,-0.03006812,0.019601222,-0.028107708,0.0006386763,0.0139145525,0.046505436,0.019337976,0.053335648,-0.0077090077,0.0014642068,0.047734734,-0.058187183,0.0031310897,-0.085439675,0.06554694,0.039006192,-0.031924397,0.1087821,-0.015861055,-0.023919737,0.0162907,0.015379097,0.0392586,0.036381662,0.03549194,-0.021058604,-0.08522807,0.051812585,-0.0006807816,0.04109911,-0.09031125,0.03509211,0.08323155,-0.061762664,0.0071094874,0.07147063,0.043500394,0.007976531,-0.06711693,-0.0059076934,-0.04895491,-0.022542065,-0.06790882,-0.03362437,0.031208377,0.011058788,-0.020207679,-0.06898711,-0.010439731,-0.044730697,0.027701095,0.009428831,-0.0048567643,-0.018353498,0.022074373,-0.033412404,0.03605304,0.07809161,-0.006113629,-0.034211207,0.06700243,0.01825345,-0.04985223,0.036660347,-0.03941893,0.013661374,0.014143254,-0.06150487,-0.07225265,0.048771974,-0.072954156,0.061962433,-0.025206203,-0.06247417,-0.008356679,0.0019145387,-0.010050189,0.06706368,0.03970281,0.013455535,0.059517737,0.029812705,0.02210816,0.03748347,-0.01792423,0.06361373,0.022907898,-0.043478336,0.007303532,-9.857506e-05,-0.046624493,-0.049297184,-0.018910611,0.022586957,0.05522552,0.015146035,0.021191472,0.055395585,0.07958135,-0.029163584,-0.104940385,-0.03277593,0.033361465,0.013556193,0.08378473,0.059394382,0.03446941,-0.04890433,0.0044320305,0.043879665,-0.033376407,-0.06900873,0.11372775,0.014172014,-0.064132124,-0.08468414,0.0077978414,-0.00827154,-0.09140068,-0.016849905,0.028063603,-0.044507444,0.014107715,-0.06438759,1.9417811e-33,0.038359094,0.059665363,-0.02881917,-0.0671158,-0.040592484,-0.06267351,-0.10009388,-0.026781015,-0.10543361,-0.01252793,-0.003992399,-0.0018133174,-0.017510362,0.035338257,-0.02098667,-0.12401193,0.036669858,0.08096487,0.02477122,0.03123218,0.07405626,0.023785906,-0.09970664,0.04906298,0.043929268,0.094847575,-0.06528564,-0.018724073,0.03652136,0.0039143614,-0.00059953437,-0.06045612,-0.09461548,0.022494286,0.03739008,-0.09925721,-0.06832074,-0.026164213,0.09529107,0.008152867,-0.061955255,-0.01830258,-0.020646611,0.01665253,0.042039003,-0.05234187,-0.020202098,0.117221415,0.047953222,0.038426943,0.022362554,-0.06134871,0.029136855,-0.008595792,-0.082537316,0.03359283,-0.057287615,-0.0355831,0.06159684,0.04399146,0.020858468,0.051206715,-0.054564215,-0.030647993,-0.026695738,-0.035141658,-0.032394186,-0.06628715,0.09395349,0.11298216,-0.109289534,0.040715426,0.027961344,0.01330304,0.05331313,0.016338797,0.018880058,-0.041725665,0.03801958,0.04360994,0.034677442,-0.03262263,0.029347098,-0.012890591,0.0030250938,0.0004063692,-0.004703934,-0.053861413,-0.032207046,0.06537146,0.031876165,-0.057622198,-0.10206904,-0.04646576,0.04523311,-3.518126e-33,0.15302695,-0.024454867,-0.035842646,-0.096684545,-0.08760132,0.0016174653,-0.027868563,-0.06980643,0.031326797,-0.024187908,-0.0149729485,-0.014501503,0.011720251,-0.05810366,-0.035820425,-0.0031893062,0.06773284,0.081540376,-0.018877452,0.036436256,0.014001594,0.06241574,-0.00058762444,-0.027362598,0.037260726,0.04583265,-0.02549458,0.07208883,0.04300711,0.14636287,-0.04925664,-0.026276402,-0.015678098,-0.027269559,-0.025596138,0.064206064,-0.10132239,0.025568716,0.0065611755,0.04092518,0.031952642,-0.06323135,0.01619444,0.03625236,0.035914794,0.02142473,-0.07138388,0.08528138,-0.035120808,-0.08578331,0.047585398,0.07667923,-0.041107845,-0.0016899329,0.014119448,0.059992194,0.035727065,-0.045190983,-0.044523854,-0.06479365,-0.029225796,-0.067443565,0.025338633,-0.002712147,0.0026209569,0.08552412,0.021777915,0.021967197,0.010033624,-0.005094584,0.050662525,0.039292205,0.05502627,-0.03914327,0.033879682,-0.00062736653,-0.11868196,-0.043207332,-0.043621637,-0.017530056,-0.031362176,0.018844742,0.0013181783,-0.12043898,-0.007757471,-0.036520958,0.020458015,0.031304862,-0.01335602,-0.012933395,-0.0006066325,-0.006698464,0.00047078347,0.028457787,0.04309354,-4.0736364e-08,0.028153222,-0.05137573,0.07506602,-0.018346377,0.002258037,0.059880096,0.043138422,-0.012795507,0.06565181,-0.012367949,-0.0013948772,0.10636079,0.016946817,-0.019534891,0.111190215,0.03841052,-0.00456469,0.041685652,-0.06285612,-0.06329348,-0.0017340007,-0.012059153,-0.10384241,0.06278215,0.0062407465,-0.0005868563,0.049548466,-0.023231542,-0.051544875,-0.0002278138,0.053842217,0.0301869,-0.0560913,-0.028293809,-0.01606495,0.006856357,-0.0829904,0.018748982,-0.01982841,-0.07257247,-0.01213969,-0.0027788025,-0.12415037,0.059368957,-0.015375205,0.08687538,-0.02368418,0.009268749,0.014968034,0.011743001,0.06450183,-0.012059462,-0.051057324,-0.037340153,-0.075771846,0.033037536,0.048468113,-0.06371367,-0.046805568,-0.0508993,-0.019297305,0.022567218,0.20168094,-0.06877079 +3.1.4.62,"This activity, which is similar to that of EC 3.1.4.3, phospholipase C, has been characterized from mammalian cells [1-4]. Multiple enzymes have been shown to catalyse this activity, including human sphingomyelin synthase-related protein (SMSr, gene name; SAMD8) [6-8] and sphingomyelin synthase 1 (SMS1, gene name; SGMS1) [9] (cf. EC 2.7.8.27, sphingomyelin synthase). Minor activity was also observed by sphingomyelin synthase 2 (SMS2, gene name; SGMS2) [10].",384,1.0,-0.042944916,-0.11580044,-0.10141402,-0.0047464343,0.048731126,0.022042355,-0.013820852,0.0019990485,0.039189443,0.022789452,0.079077005,-0.019949265,-0.057755917,0.073870115,0.0014072618,0.04645118,-0.09856618,-0.044722095,0.008264157,-0.07306193,0.082371905,0.012703757,-0.011424656,0.024500813,0.046034116,-0.0319939,0.047264643,-0.01687563,-0.0086798975,0.022509519,-0.0102428775,-0.034987748,0.034244042,-0.036619145,-0.005014978,0.06326852,-0.07746079,-0.026595782,0.06025194,-0.021838654,0.06564774,-0.080097646,-0.022770334,-0.059042368,0.004049591,0.042215653,0.0043867896,0.03574474,0.0014890572,0.008716102,-0.048917055,-0.038429294,0.0064615975,-0.036631856,-0.0965857,-0.015884174,-0.13752577,0.084979326,0.058755275,0.013963994,-0.030145759,-0.033468835,0.036318373,0.031412844,0.010641395,-0.026373759,0.0014715822,-0.12396392,-0.03624287,-0.025325648,-0.02392762,-0.0832871,0.028414603,0.07603002,0.056184273,0.1247103,0.021785121,0.02586679,-0.046891876,-0.07786715,0.09867244,0.009784033,0.03006079,0.071592726,0.06231789,0.00805165,-0.011942898,0.04873916,0.0074277665,0.025132088,0.045675095,-0.029555291,0.04017875,0.065338835,-0.07037289,0.11465805,-0.10060187,0.084788285,-0.03307367,-0.04509908,-0.063674904,0.04079425,-0.013745734,-0.03209613,0.027336042,0.05782895,0.0018344771,0.010700133,-0.052651666,0.016796604,0.06106942,-0.010171728,0.028356599,-0.0371592,0.04497872,0.03656828,-0.016044449,-0.040948432,-0.020912161,0.007435616,0.031872075,-0.023459876,-0.008008642,0.01613091,-0.06817736,0.046658657,-0.0681821,1.6626113e-33,-0.021138825,0.05319839,0.03484926,-0.018361676,-0.013779076,-0.03100043,-0.010051061,0.015358455,-0.03329111,-0.06567286,-0.05083824,-0.047220953,0.02136306,0.053091656,-0.0032499335,0.026779464,0.042375505,-0.030225338,0.05598409,-0.013431179,0.0055586677,-0.030572975,-0.00873302,-0.04038688,0.06028634,0.0001779801,-0.10616845,-0.026402831,0.052268013,-0.03248581,0.00076112535,-0.029251587,-0.057282973,-0.006442865,-0.04157299,-0.033678092,0.005294827,-0.05365654,-0.006884656,0.011913374,-0.07865516,-0.02274675,-0.056121033,-0.05387159,0.026037002,-0.042633947,-0.09710099,0.042283595,0.01915865,-0.029475987,0.03899827,-0.024731243,0.10549559,0.040679526,0.015516917,0.0009638048,-0.013327895,-0.06885948,0.017924882,0.025899112,-0.02304281,0.06112294,0.015820056,0.029967632,-0.0056879246,-0.05164812,-0.06664824,-0.08230065,-0.13399473,-0.026469,0.0013936477,-0.012174346,0.05108882,-0.02976218,-0.043569338,-0.04481874,0.045591258,-0.01458849,-0.0213526,0.053503495,-0.0054114624,-0.0335829,0.0004800641,0.033850748,-0.014399586,0.010617136,-0.0037425351,-0.073739804,0.0037810232,-0.018031005,-0.0065900562,-0.060877215,-0.092564024,0.08496011,-0.057945196,-4.0092016e-33,0.028691297,0.002938678,0.0065490096,-0.11694404,-0.066861406,0.08669807,0.026016437,-0.0018861853,0.05012369,0.0069799637,-0.022191584,-0.012274994,0.05090821,-0.12252911,-0.0065327184,0.01510877,0.00614698,0.079687126,0.047131073,-0.014352566,0.040880375,0.15853372,-0.018022556,0.12352665,0.032809008,-0.024715176,0.012353457,0.10456837,0.0051527964,0.06891703,-0.042468987,0.010749149,0.0053924453,-0.05651451,0.06350168,-0.0027251786,0.02135123,-0.016395934,0.07690042,-0.02194739,-0.009013639,0.05299705,0.035826012,0.0508194,0.09519258,0.095086925,0.014049271,0.05170923,-0.121511914,-0.03918815,0.02112414,0.031049896,-0.017214287,0.044891145,0.039981287,0.017141607,0.021991722,0.049282636,-0.02971269,-0.07377941,-0.03523339,-0.04851918,-0.011103365,0.016864294,0.09593571,0.051233124,-0.08628003,0.07414349,-0.0012867268,0.018816534,0.008074672,-0.023571411,-0.12373348,0.026613554,-0.0077421283,0.01515901,-0.06015516,-0.0077065118,0.046853118,-0.00044773374,0.02856139,0.05524877,0.067553036,-0.040079128,0.036574215,0.033943508,0.018627588,0.06916264,0.026070032,0.032232273,-0.020404954,-0.02750525,-0.036751937,0.026590168,0.036969338,-4.5072316e-08,0.074853204,-0.0125388075,0.051264886,-0.11343885,-0.036822513,-0.09496918,0.01266329,0.008037821,0.05801057,-0.069325775,-0.07453992,-0.015600686,0.06961097,0.014593493,0.07300438,0.058925122,-0.04429573,0.013586637,-0.030424714,-0.050193474,0.087852694,-0.032977674,-0.08392,0.068438575,0.037333716,-0.08288024,0.046283204,0.035830773,-0.07307847,0.020288106,-0.0039747558,-0.043655038,0.03452306,0.0020506077,0.017894136,-0.008387417,-0.009518943,-0.06681828,-0.030767761,0.03489091,-0.061855465,-0.08367784,-0.016742693,-0.01598148,-0.01532945,0.03632191,-0.005716519,-0.04585051,0.08634765,-0.05863807,-0.012989323,-0.013189584,-0.035032984,-0.05932217,-0.102465615,-0.07647881,-0.039547764,0.034599595,0.08315102,-0.122684926,0.03351577,0.084787145,0.11386522,0.0030365665 +3.13.2.4,"The lanthipeptides are a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) that is characterized by the presence of multiple lanthionine (Lan) and 3-methyllanthionine (MeLan) crosslinks, which are formed by lanthipeptide synthases. These enzymes catalyse dehydration of Ser/Thr residues, followed by intramolecular addition of the thiol group of a Cys residue to the dehydro amino acids, which results in the formation of the thioether crosslinks of (methyl)lanthionine.",384,0.99999994,-0.0049961223,-0.09453122,-0.024362726,-0.085881785,0.06983422,0.0015572837,-0.029788267,0.0794456,0.045749776,0.02544338,0.046016704,0.0063216086,0.0018048399,-0.009996616,-0.035996027,0.03834096,-0.08677982,0.059177216,0.046935294,0.019298652,0.048313152,0.08183086,-0.039659996,0.023289567,0.03226044,0.0022687223,0.073711686,-0.0057284934,-0.012593438,-0.028936021,-0.0026644117,-0.00979223,-0.07724307,-0.012092049,0.012124561,0.12819785,-0.072783254,-0.021451006,0.022207947,-0.08477947,0.059977822,0.0040282854,0.010671135,-0.040896583,0.0012714851,0.013367439,-0.05722693,0.07954286,-0.0051561906,0.053095605,-0.05231209,-0.030286437,0.0026670678,0.04347159,-0.055122294,0.000105099774,-0.06908698,-0.024358498,-0.002050894,-0.056129582,-0.03953427,0.0030077498,0.047932465,-0.044490803,0.06624719,-0.0038422877,0.026929984,0.01622837,0.042957537,-0.007462326,-0.02381981,-0.06718891,-0.03474036,0.104875535,-0.03914651,0.049535763,0.0062021576,-0.026595533,-0.09180786,-0.041934356,-0.00935381,0.019038865,0.033163,0.11560559,0.056018565,0.06746689,-0.017846534,0.04059742,-0.022565145,-0.022054955,0.06288015,-0.005783885,-0.0014870603,-0.04485933,-0.05454164,0.0041535203,-0.046116788,0.03617986,-0.04883783,0.00018762058,0.0012544802,0.03599146,0.013401639,-0.096997656,-0.029408088,-0.034561932,-0.004866294,0.024051467,0.019082863,-0.061427467,-0.041610118,0.021754725,0.011642632,-0.046609595,0.0009809874,0.060628876,0.022652399,-0.021368396,0.011530335,0.0024349287,-0.003682569,0.013363326,0.062058866,0.06834183,-0.058896534,0.038572688,-0.13570791,3.369054e-33,0.06339933,0.031183507,0.07855964,-0.018077422,0.024515387,-0.08324178,-0.02545205,-0.07313835,0.0062891683,-0.068378426,-0.11255778,-0.113845,0.07791293,-0.034066267,0.0099835815,-0.1354921,-0.045373864,0.060526397,0.07837722,-0.07311679,-0.096824944,0.07263131,0.055505123,0.048513945,0.0087044975,0.0038815746,0.014550532,0.00091551204,0.029161736,-0.008560511,-0.0093879495,0.033281393,-0.0805694,0.023397839,0.0010116986,0.03741832,-0.023425616,-0.08770536,0.07205514,0.09359678,0.013479984,-0.031235656,0.025430834,-0.0142590115,0.059295185,-0.039666574,-0.09921546,0.060900133,-0.056422904,0.0013136518,0.05711367,-0.057064783,0.036085725,-0.04737865,-0.048321832,-0.013814911,-0.04837562,-0.089698456,0.046734236,0.08141017,0.031032009,0.029506337,-0.021707647,0.017138971,-0.054768648,-0.041114002,-0.013437203,-0.059151888,0.02411325,-0.018131081,-0.021335335,-0.051696695,0.0694747,0.063150436,0.022678766,-0.021972714,-0.13118045,0.0047472906,0.041605905,0.05032719,-0.017342763,0.045275748,-0.060619753,-0.054132216,0.051105827,0.008374263,-0.0010231334,-0.15324399,0.05893364,8.859375e-05,0.022045918,-0.044628575,-0.0827118,0.017453324,-0.046292625,-4.5276663e-33,0.03242357,-0.08329578,0.02273362,0.061938863,-0.06965434,-0.041687783,-0.034403063,-0.037371214,0.07832181,-0.05542775,0.070738256,-0.041249577,-0.034454636,-0.08783685,0.051122658,-0.04509894,0.09655284,0.040285278,0.04655583,-0.011764249,0.013640814,-0.0015887681,-0.0063947337,0.058553867,0.034305986,0.0155799845,0.007075521,0.04261204,0.117481865,0.011617135,0.04278094,0.05494141,-0.020137256,0.0067206332,0.02840817,0.10503758,-0.03067946,0.0023637419,0.053984858,-0.014329914,0.042887796,0.052704506,0.041352868,0.031885173,0.054846007,-0.03216363,-0.00769727,0.0021659837,-0.02441049,-0.11513707,0.115095355,-0.031181958,0.043872323,-0.021215493,0.01809126,0.022830287,-0.026545571,0.02195866,-0.010780712,-0.059595324,-0.039718587,-0.04914879,0.006010634,0.0019737622,0.016627066,0.025135677,-0.002739357,-0.070696786,0.010140178,-0.006549881,-0.017011171,0.0018103148,0.04133159,0.0018146886,0.039571498,-0.0645144,-0.12032408,0.04468447,-0.0031365799,-0.1153944,-0.022833746,-0.019221473,0.029877696,-0.035049904,-0.0033544395,-0.06300436,0.010066117,0.12760115,-0.0145938145,-0.050669402,-0.030906236,-0.06770294,-0.014177999,0.14876617,0.041654576,-4.2532672e-08,0.11930245,0.011322929,-0.050460964,-0.010591872,-0.03468327,0.001520926,0.05779205,-0.03494527,-0.012699363,-0.013605704,-0.0068368567,0.0735465,-0.017226046,-0.024835045,0.0135207875,0.027552582,0.0014247798,0.08223361,0.00080093765,-0.0009920439,0.003953182,0.043193076,-6.733182e-05,0.03524851,0.03795886,0.012741507,-0.010313253,-0.05506542,0.035334427,-0.023060208,0.009818954,0.03548634,-0.012892643,0.009481155,0.018326815,0.049651984,-0.0794371,0.0054775113,0.08798341,0.07829578,-0.09816424,-0.02184082,-0.06391896,-0.0033324244,-0.0020483506,-0.04254866,0.0068582054,0.07237601,-0.14205346,-0.06383627,0.016958715,-0.00017613017,0.057581026,-0.05939356,-0.050705828,0.048303947,0.01043346,-0.07124221,-0.0023033018,-0.06065261,-0.030794665,0.021271594,0.118742,0.018403813 +4.1.1.128,"The enzyme has been described from pathogenic Bacillus species, including Bacillus anthracis, Bacillus thuringiensis, and Bacillus cereus. The enzyme requires an NAD cofactor, and the reaction proceeds via a 4-dehydro intermediate, resulting in reduction of NAD+ to NADH (cf. EC 1.1.1.305, UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)). However, NADH is not released from the enzyme and is recycled back to NAD+ at the completion of the reaction cycle. The product is incorporated into an extracellular polysaccharide known as pzX.",384,1.0,-0.060888074,0.0032929091,-0.050515767,-0.037462596,-0.0072672125,0.046021953,-0.07984651,0.037273142,-6.5885088e-06,0.0728609,0.013890651,0.014657314,-0.028994985,0.035085384,-0.059244633,0.017797593,-0.025913483,-0.006521805,0.034800883,-0.039337844,0.09702905,0.056842104,-0.0030224726,-0.046737876,0.011544949,0.017829262,0.040450778,-0.04321509,-0.0133391945,-0.058797404,-0.06090935,-0.0056331493,0.027532103,-0.062254377,0.027656268,0.12012982,-0.07186736,0.011048595,0.041477717,-0.022843903,0.059852354,0.015170834,-0.0389004,-0.027397312,-0.038361512,0.0023125326,0.006509094,0.040693678,0.05179103,-0.055478405,-0.0056531853,0.013597915,-0.007895285,0.039134964,0.026329484,-0.08682129,-0.024095435,-0.012832614,-0.033633146,-0.03743858,0.047294453,-0.058185693,-0.016045537,0.0035052905,0.063484885,-0.04085713,0.013723143,-0.07265531,-0.040090676,-0.037540905,-0.11189668,0.04081598,-0.024524441,0.0020620483,-0.024497824,0.059251156,-0.023953052,-0.059619173,0.06405822,0.020335881,0.08775122,0.04452342,0.0017685853,0.08053245,0.06788746,0.011290222,0.011046042,0.02902778,-0.03514662,-0.003416217,-0.010095439,0.0021134857,-0.020881929,0.064289495,-0.16753754,-0.0018456504,0.033164028,0.024743207,0.06928158,-0.074088395,-0.01051992,0.04877108,-0.006936904,-0.112177886,-0.07796736,-0.014435606,0.003092909,0.08771862,0.02000306,0.058118865,-0.059965283,0.08149072,-0.020709023,-0.012619573,-0.030241761,0.106724136,0.04243272,-0.044791713,-0.03485125,-0.09632349,0.005950581,0.025123807,0.0460197,0.03692618,-0.005812112,-0.0005215818,-0.08920924,2.315496e-33,-0.00023905742,0.013772499,-0.005894838,-0.017605396,0.046887286,-0.0015851791,-0.06960684,0.03363509,-0.054001864,-0.015359388,-0.053906925,-0.07660568,0.07425803,0.060442347,-0.048445627,-0.006397804,-0.03741861,-0.05686993,0.022364281,0.024832966,0.018284759,0.08456341,-0.030123672,0.049716778,0.058898695,-0.0014248237,0.0028074372,0.07074863,-0.009558425,-0.042260252,0.046160486,-0.09476242,-0.08590895,-0.060340483,0.08852174,0.005718174,-0.07148792,-0.0003808507,-0.047813777,0.01772531,-0.043986674,0.0065622116,-0.040156417,-0.043061096,0.024526143,-0.06613317,-0.03206761,0.025632963,0.02835581,0.024992656,0.10666448,0.0056422898,0.09389641,-0.055052847,-0.070106044,0.035191443,-0.004758219,-0.031760477,-0.0030621027,0.072484344,0.10098155,0.029391283,-0.08756502,0.09928502,-0.03962666,-0.006163673,-0.052498903,-0.017063651,-0.002223511,0.014853925,-0.046744272,-0.0030794453,0.040316157,-0.0436744,-0.044284575,-0.009390531,-0.03813995,-0.016011838,0.05236487,-0.003164031,-0.000974889,-0.026155923,-0.017511124,-0.012535245,-0.03697063,0.02534151,-0.012042152,-0.01574799,0.03292059,0.013020882,0.017987078,-0.12521303,-0.014950415,0.022283066,0.016935285,-4.522265e-33,0.11207202,-0.014373983,0.043600433,-0.103687234,0.007535537,0.08854729,0.11794267,-0.015537594,0.01868281,-0.04778829,0.029671192,0.06741728,0.07730712,0.058336042,0.073298976,0.03123714,-0.0459344,0.08561226,-0.05981789,-0.05582688,0.01581797,0.1679367,0.059564345,-0.056477547,0.0063230516,-0.021640131,0.024411445,0.118958734,0.028025763,-0.0057156454,-0.01307768,-0.0036437649,-0.06375735,-0.04099461,-0.04299089,0.010554904,-0.06748456,-0.036323715,0.04755401,0.010238756,-0.022998465,0.012888936,-0.10482113,0.018678289,0.118621364,0.08749349,-0.0941939,-0.03291358,0.05042797,0.010353514,0.029127864,0.06307505,-0.016798478,-0.005692669,0.032909542,0.02824062,-0.010746876,-0.0013114475,0.086987816,-0.042647693,-0.061439063,-0.07998488,0.09433807,0.009752116,0.019358654,0.031410992,0.0043719127,0.020409156,0.05125562,-0.0279389,0.04809999,0.10768899,-0.06364244,0.05618098,-0.046659503,-0.0051631886,-0.1042485,0.021620013,-0.02917919,0.022702986,-0.021399675,0.006071387,-0.002237654,-0.025410516,0.038530637,-0.06773815,0.030131556,0.046196356,-0.0034222754,0.030456405,-0.017835345,0.006853267,0.0054559587,0.08526824,0.011491493,-4.2624873e-08,0.014044592,-0.020784464,-0.022897227,-0.04017222,-0.012963268,-0.0031015228,0.017602487,-0.046748437,0.05600851,-0.0825304,0.021347806,0.09338202,-0.022180153,0.08316823,0.0118326275,0.0037462737,-0.06863282,-0.078621,0.016253483,-0.055449277,-0.09592274,-0.03243732,-0.13262376,0.10413634,0.0064192438,-0.029098198,0.017481508,-0.014193922,0.0034665086,-0.08158976,-0.017225612,0.07901683,0.044715814,-0.072418414,-0.08259908,0.044869944,-0.04449885,0.032004062,0.032544877,0.056170285,0.048483722,-0.055093028,0.006590485,0.021660056,-0.0062724934,0.016599609,-0.039906822,0.006871813,-0.011360619,0.019637553,0.043683514,0.021986557,-0.053550042,-0.055135716,-0.05936112,0.03525653,-0.045629147,-0.07421365,-0.0076183765,-0.0717009,0.017220452,-0.013163463,0.13513926,-0.029724596 +4.1.1.129,"The enzyme, characterized from the bacterium Chondromyces crocatus, catalyses the final reactions in the biosynthesis of the antibiotics chondrochloren A andchondrochloren B.",384,1.0,-0.0462375,-0.012298197,-0.09320279,-0.012028644,0.024127034,0.058079265,-0.115610026,0.08800374,0.02591929,-0.0001954003,-0.010555656,-0.05969409,-0.066753305,0.01838722,-0.12337116,0.070263475,-0.10046122,0.010706256,0.02323639,-0.016782869,0.041734755,-0.007842381,0.015757384,0.024730729,-0.0015641613,0.022845106,0.06208546,-0.01946701,-0.016777975,-0.039831482,0.03451015,0.03476134,0.14980745,-0.06580719,0.06387081,0.060819935,0.018603304,-0.050068628,0.10446879,0.01710697,-0.01835173,0.005441877,0.038583867,0.019891463,-0.021694891,-0.011964322,0.059126355,0.019497044,0.0013572033,0.035354882,0.0008519763,-0.012043538,-0.082255416,-0.020246245,0.07661607,0.056389228,-0.06603997,-0.06202605,0.024024285,0.015943779,0.044158,0.016281378,-0.01712803,0.0066195084,-0.015423419,-0.055636637,0.05409279,-0.08138446,0.0014189132,0.030362803,-0.04345176,-0.036874507,-0.017040258,-0.040911146,-0.0034140504,0.025605023,-0.031482905,-0.045667823,-0.039130855,-0.083620586,-0.017031584,-0.04341077,-0.039909337,0.05386205,0.05318588,-0.06792888,0.04922494,0.011737134,0.08785188,0.054291,0.01639603,0.009261235,-0.005046475,-0.046405982,-0.092239685,0.023750504,0.04735821,0.025538307,0.048121046,-0.007891314,-0.015384335,0.05916655,-0.004278136,-0.14518793,-0.019708697,0.0072382456,-0.020527527,0.105526865,0.06105478,0.0021546101,0.033843964,-0.016134106,0.009837235,-0.035965655,-0.022528814,0.10863414,0.021965466,-0.06713408,-0.060485333,0.05993936,0.017211793,-0.003907383,-0.022855422,0.044233933,-0.09796852,-0.00013791678,-0.07093164,3.555583e-33,0.024681974,0.04000962,-0.05146662,-0.0027941735,0.0052520717,-0.03758374,-0.090293266,0.006895488,-0.04974099,-0.028362907,-0.013589395,-0.012400446,0.015766004,0.01483192,-0.019361708,0.037440654,0.06259601,-0.04208825,-0.043604277,0.051017307,0.016348777,0.054892376,-0.10658644,-0.0025056305,0.04307989,0.016416095,0.053543378,0.068600036,0.06849598,-0.039949887,0.03304001,-0.06788966,-0.018706907,-0.008570588,0.040424872,-0.0147582395,-0.030191576,0.0031824592,-0.016706912,0.06197411,0.028554313,-0.05346459,-0.06259845,0.008980168,0.09068495,-0.0021868872,0.034606345,0.030263538,0.05766248,0.014082989,0.06254584,-0.036084328,0.10845942,0.049855575,-0.016987095,0.05954552,-0.053848412,-0.007998432,0.0074522495,0.051976804,0.016639674,0.02433852,-0.018277543,0.04509937,-0.0017509543,-0.034204584,-0.0070698103,-0.055861533,-0.040828448,0.016534843,-0.08955812,-0.045322645,0.07310575,0.04459542,0.0061170836,-0.011053165,-0.026916523,0.007354442,-0.028127592,-0.030166484,-0.047721367,0.035841357,0.023418771,-0.08441293,-0.06307932,0.016047874,-0.08220999,-0.05426746,-0.05646486,0.018856326,-0.024203962,-0.094516285,-0.055771343,0.047157533,-0.007985277,-4.5947863e-33,0.043006033,-0.07442761,0.011177622,-0.08167595,-0.12615818,0.14404118,-0.0018939591,-0.03312996,-0.019897254,-0.020090595,0.0071941502,-0.036404114,0.04299399,-0.085735366,-0.017505465,0.039580427,0.08873149,0.06359782,-0.059726372,0.0042467276,-0.03033412,0.15353023,-0.008229473,-0.0071982555,0.058023904,0.06512208,0.017043356,0.08336709,0.003582679,0.08279894,0.005657795,-0.09400493,-0.025439644,-0.011648867,-0.06845936,0.1182233,-0.026151288,-0.047577325,-0.023042828,0.027379224,-0.021387426,-0.0059443684,-0.0021171463,0.057981454,0.040212166,0.05157516,-0.08023494,0.023846414,0.011855654,-0.11581058,0.017242683,0.038866285,0.01212976,-0.030064253,0.076473676,0.071823284,-0.027672116,-0.020324942,0.085871756,-0.047564823,-0.059331544,-0.029005498,0.10015957,0.012184399,-0.0141628785,0.0860216,-0.0761828,0.01796445,0.04668415,-0.024035502,0.057753313,0.12159731,-0.019473957,0.11567337,0.035231728,0.052328553,-0.046166383,-0.099529386,-0.06192932,-0.022076312,-0.026702616,-0.026842833,0.074278556,-0.021969985,-0.052405152,-0.047163285,0.03107508,0.04942141,0.0025053509,0.024240818,0.060006402,0.011063902,-0.053747572,0.02968932,0.03250574,-3.2366398e-08,0.051248576,-0.07235436,0.05231023,-0.07685127,0.018719569,0.009746758,0.0043619336,-0.03585846,-0.0006764542,-0.023226881,-0.11095491,0.025792772,-0.006402136,0.04470323,0.009560169,0.08426099,-0.013619826,-0.044910394,-0.02968126,0.06113752,-0.05841289,0.011100984,-0.085663795,0.035814866,0.025722438,-0.04576331,0.0148329055,0.02909162,-0.06879621,0.022343136,0.013345172,0.01798713,-0.031976566,0.029036282,-0.01605882,0.011880366,-0.014943031,-0.077591956,-0.006271346,0.041837145,0.07966841,-0.01827686,-0.060678825,0.036608573,-0.057360657,-0.039197475,-0.030828565,0.0067535113,-0.012784741,0.009290898,0.069736965,-0.009481409,-0.049632825,-0.019688249,-0.07389394,-0.029589,0.021924347,-0.06669152,-0.046444904,-0.03693871,-0.030647047,0.0024069687,0.16035548,-0.02032211 +4.3.3.9,"The enzyme, found in a number of bacterial strains, is a non-ribosomal peptide synthase (NRPS). The enzyme forms 3-amino-1,5-dihydropyridine-2,6-dione, which undergoes spontaneous oxidation to form the blue pigment indigoidine.",384,0.99999994,-0.05634642,-0.08484532,-0.1034711,0.020380296,0.08782614,0.027549295,-0.028819038,0.05903948,0.086815566,0.013409446,-0.002797935,-0.028757665,-0.035005625,0.112204604,-0.06597439,0.07761657,-0.04972953,-0.04100541,0.02003676,-0.042755395,-0.028567653,0.05410533,-0.029871603,-0.0046940413,0.043303613,0.027150186,0.099053994,-0.045380514,-0.02007382,-0.027065793,-0.010288836,0.006260606,0.058059424,-0.11801985,0.12216754,0.029418588,-0.0554231,-0.0101079885,0.051319845,-0.017735202,-0.0016855132,0.015053165,-0.043444302,-0.021332571,-0.012786202,0.042650465,0.018336391,0.076166764,0.028082754,-0.061047204,-0.08147339,-0.040024497,-0.010106812,0.033058286,0.042280175,-0.033683367,-0.06353129,-0.104050756,-0.036966983,-0.0019629179,0.021337122,-0.020052057,0.022358514,-0.0070799305,0.054829452,0.030792156,0.020778941,-0.018050682,0.03494367,-0.07575099,-0.06793377,-0.10004977,-0.018062916,0.08054499,0.012770109,-0.034588847,0.07176872,-0.024145933,0.049831524,-0.0101411445,-0.004150181,0.008971297,0.032384366,0.105420046,0.022344485,0.056898028,0.09046722,0.016090913,-0.011348788,0.010648397,-0.015463109,0.019547632,-0.0024017973,-0.09721541,-0.093402915,0.030342162,-0.061961055,0.02914926,0.036603466,-0.012204259,0.0135028595,0.01743986,-0.010559357,-0.06802062,-0.09479951,-0.04715933,0.011745834,0.083324954,0.0054856236,0.0013777104,0.092070535,0.03616747,0.005013527,-0.032403193,0.024239909,0.077948906,0.036473606,-0.038695585,-0.1030039,0.1159467,-0.014888645,-0.043080438,0.026543628,0.08462531,-0.064447835,0.0806581,-0.094397746,-1.576249e-33,0.046520993,0.038864464,0.0043401374,-0.049122747,0.019294366,-0.00887671,-0.050844897,-0.005630454,-0.052456632,-0.055545878,-0.053369306,-0.08886774,0.042259704,-0.02315505,0.029968183,-0.0036774927,-0.07783925,0.03437421,0.012133721,0.047735628,-0.022577005,0.102679715,0.0043220883,0.01916728,0.030945396,0.05705802,-0.03272361,-0.035982225,0.09049005,-0.02920968,0.11695598,0.025911935,-0.13453603,0.03934461,0.009813283,-0.020459672,-0.00261243,-0.052276567,-0.011046086,0.042163547,-0.00021762494,0.093489945,-0.035925113,0.062100656,0.066014454,-0.014538821,-0.030714016,0.06990789,0.00758094,0.048734967,0.0069771693,0.06796735,0.11393212,-0.07891795,0.016947921,0.04673031,-0.020535203,0.009881767,0.090648465,0.004711122,-0.039859463,0.039580084,-0.047950022,0.01661061,-0.0060334755,-0.00999509,-0.02711329,-0.08558406,0.07730099,0.029810933,-0.042374626,0.036748655,0.041856676,-0.00020123525,-0.017913662,-0.10541616,-0.05875944,-0.018858623,0.049536042,0.007127513,-0.066333786,-0.012776577,-0.0007235395,-0.067483515,-0.011138095,-0.050195824,-0.033818565,-0.01853312,-0.025316672,0.017733922,0.10101646,-0.051520802,-0.1192495,-0.0066048983,-0.032901164,1.0119317e-33,0.08482797,-0.12534031,-0.06143395,-0.01960551,-0.022430394,-0.013255123,-0.028565105,0.015352173,0.055737074,0.01282346,0.119053744,0.043059114,0.015698822,0.0456692,0.044598162,-0.059049692,-0.0026575134,0.08094863,0.002125542,-0.01927645,-0.03112034,0.046425205,0.0025143367,0.013474978,0.012057412,0.10568048,-0.03139507,0.075813025,0.057990707,-0.0011262413,0.031687602,0.08069755,-0.03282512,-0.049412105,0.01406236,0.07926677,-0.016093059,-0.0017809451,-0.009040358,0.050619934,-0.01711286,0.08742228,-0.03034275,0.058704324,-0.0332983,0.0034921903,-0.04698043,0.08114843,0.040442593,-0.115580596,0.03765042,-0.029614335,-0.029093377,-0.018990148,0.008774423,-0.014196318,-0.02077801,0.07986547,-0.004004584,0.013508363,-0.017771311,-0.09642475,0.051197212,0.020705849,0.026546922,0.042283677,0.031000651,0.0365255,0.044459965,-0.031650756,0.009176721,0.012813503,0.049466886,0.014756789,-0.0010314082,-0.04148021,-0.029268164,0.0033697053,0.04492584,-0.03287583,-0.025479324,-0.012045281,0.02474802,-0.0079771,-0.035596713,-0.092365846,0.023764517,0.07848961,0.022485685,0.0029142618,-0.008581051,0.024677875,-0.026257696,0.031455312,0.047952626,-3.503759e-08,0.08242128,-0.049560875,0.093699664,-0.021673724,0.074239016,0.015674239,0.017324833,-0.05731429,0.02066138,0.017927172,-0.024516426,0.084355555,-0.044574913,-0.07094553,0.08553783,-0.010071631,-0.027084528,0.011258787,-0.052194767,-0.012090185,-0.049892675,0.027219774,-0.07658777,0.019621171,-0.03051392,-0.037418175,-0.013355101,-0.05912682,0.04468418,-0.019163402,0.001005019,0.07336029,0.0637728,-0.024714686,-0.1255878,-0.03179419,-0.08659982,0.001386765,-0.03867685,-0.016251987,-0.038603637,-0.042049307,-0.102098204,-0.05344824,-0.050889995,-0.0057779774,-0.018526493,-0.032000184,-0.06434077,-0.038203046,0.01248104,-0.044123802,-0.004714073,0.0061397757,-0.090893336,-0.0038224976,0.0065446924,-0.05191428,0.0011204593,-0.057185408,-0.052414466,0.0034201937,0.12759924,0.011780979 +5.1.3.45,"The enzyme is found in bacteria and participates in the biosynthesis of assorted bacterial lipopolysaccharides and capsular polysaccharides. It contains a tightly-bound NAD(H) cofactor. The enzyme also catalyses the activity of EC 5.1.3.7, UDP-N-acetylglucosamine 4-epimerase, with lower efficiency.",384,1.0,-0.027777553,-0.008675381,-0.075618915,-0.032072656,0.08506923,0.09549918,-0.034559704,-0.018976204,-0.019143796,0.057945523,0.015852569,-0.055421513,-0.06609533,-0.0054304632,-0.046849787,0.010586344,-0.0305503,-0.07187254,0.021734387,-0.08059335,0.08377266,0.0013999988,0.013594799,-0.018967522,0.03252224,0.059502378,0.072175525,-0.05578838,-0.020910067,-0.12054175,0.0037762206,-0.08284438,0.08092826,-0.053379074,0.042052004,0.11961887,-0.01347811,-0.017330669,0.038922597,0.035879303,0.0147312805,0.008837106,-0.04141609,0.017685097,0.00728115,-0.06736598,0.030422803,0.054147705,0.057561126,-0.035475988,0.009690531,-0.032551035,-0.002767746,0.00246429,0.028990783,0.026571028,0.0011957507,-0.028528424,-0.015905889,-0.012841816,0.0712402,-0.04893809,0.022801055,0.0001540454,-0.038417384,-0.06370749,0.09998594,-0.10698199,-0.041655444,-0.015794754,-0.11305632,-0.01715475,-0.050928473,0.0910813,0.023157844,-0.0064253127,-0.04196896,-0.12362636,0.08327476,0.04494137,0.0030776877,0.01101849,-0.02963545,0.1131312,0.04212417,-0.029619709,0.057752557,-0.035713363,0.042398375,-0.0068275086,0.0019590543,-0.07886499,0.013067226,0.031805128,-0.14133471,0.024692062,-0.007739434,0.038443998,0.08671724,-0.049410317,0.021133125,0.037113547,-0.029298509,-0.10346438,-0.05318158,0.06524552,-0.010398265,0.124950595,0.021841157,0.03378236,-0.067305356,-0.013868049,-0.0030572168,-0.014977096,-0.052664243,0.07990839,0.008244307,-0.10803179,-0.05149845,-0.020848311,0.015525901,-0.022304982,0.103133716,0.06036557,-0.052378897,0.013767491,-0.108934894,9.8613415e-34,0.030796373,-0.014008735,-0.0051064324,-0.039377294,0.023370333,0.043688983,-0.053601723,0.020786589,-0.02017252,-0.05014123,-0.026747555,-0.068103015,0.097442694,0.06704336,-0.017918492,0.008200089,-0.04304652,-0.0021946994,-0.0035766482,0.034074962,-0.018337425,0.059039872,-0.043997396,0.026576277,-0.0016606048,0.050512284,-0.015502044,0.03853493,0.100572325,0.016776415,-0.01562711,-0.06871707,-0.1059089,0.007218548,0.066183455,0.010294276,0.0058103716,-0.0029763244,-0.0020588313,0.05710673,0.020344831,0.05124151,0.03217044,-0.068989895,0.016568707,-0.064396515,-0.021029605,0.044846583,0.07674239,0.044614386,0.033560783,-0.061466493,0.10373598,0.03356269,-0.0023739599,0.08935926,-0.052745625,-0.028633555,0.045628645,0.030751849,0.00034931058,0.052584335,-0.023531483,0.04007376,-0.034165926,0.046750493,-0.017852273,-0.053220667,0.008246057,0.06292964,-0.029568156,0.003263072,0.025444975,0.07629119,-0.007554468,-0.063132726,-0.059496954,0.01671564,0.039403345,0.021590764,-0.04132981,-0.039788563,0.028315052,-0.0071933502,-0.031506557,0.029348329,-0.042596553,-0.042191964,0.03399709,0.06732024,0.035421323,-0.07624891,-0.029661216,0.061140344,-0.02719459,-2.8213835e-33,0.120195106,-0.08684388,0.07244866,-0.090097524,-0.026669612,0.07972239,0.013037634,-0.010810454,0.033915523,-0.011196542,0.037510045,-0.01241241,0.051413946,0.0037490868,0.081142165,0.024825681,-0.013944347,0.084294386,-0.04567564,-0.0055240244,0.015107924,0.004717199,0.017471429,-0.0042983554,0.064255126,-0.03247187,-0.04596991,0.017015284,0.027915653,0.024635704,-0.088394955,-0.053252265,-0.088588715,-0.036880292,-0.045044243,-0.006234298,-0.030962696,0.0013245932,-0.021316228,-0.014084172,0.0013489984,0.04811971,-0.00081832224,-0.0021392063,0.03536649,0.079667345,-0.09119451,0.055595208,0.003285765,-0.046314564,0.025966832,0.014508794,0.008335594,0.0158621,0.0072552497,0.038498484,-0.0005422048,0.05042935,0.04599604,-0.02448975,-0.040231403,-0.057074483,0.044695422,0.027156666,0.076890394,0.026372846,-0.05205076,0.015136744,-0.014487274,-0.010759076,0.043770522,-0.027514113,-0.016437216,0.060304254,0.012290613,0.023545267,-0.117886,-0.053765003,-0.017921403,0.001770949,0.05098747,-0.015652612,-0.014603589,-0.05739715,-0.056572445,-0.03629569,0.049767166,0.07279586,-0.0114186965,0.08189981,-0.04384585,-0.013300187,-0.06462082,0.06754379,0.053493675,-3.84227e-08,-0.0061228643,-0.0029719477,0.070879996,-0.08665825,-0.033907484,0.05571336,0.050046664,-0.016639544,0.10049036,-0.074292965,0.03918644,0.13650663,0.049543872,0.077281915,-0.027536675,-0.003892297,-0.04432268,0.015600796,0.013434488,0.0029608493,-0.090015344,-0.025117746,-0.065163374,0.027668592,-0.016510043,-0.05786496,0.057817508,0.07990413,-0.03756208,-0.064113475,-0.088448785,0.043724746,-0.005404364,-0.053474266,-0.041292854,0.063224226,-0.042757746,-0.0444621,-0.065674305,0.09101952,0.047402125,-0.052381217,-0.033576116,-0.03510218,0.0071970453,0.006905998,0.025831416,0.019040743,-0.055059038,-0.017425807,-0.029868022,-0.027184682,-0.053990386,-0.08328253,-0.0680171,0.008828585,-0.039099958,-0.11112817,0.031877264,-0.068964824,-0.014445359,0.03840865,0.14816853,-0.0026810898 +5.3.99.13,"The enzyme is a B12-dependent radical SAM (AdoMet) enzyme involved in the biosynthesis of oxetanocin A. The enzyme catalyses an oxidative ring contraction, forming an oxetane aldehyde. The reaction requires S-adenosyl-L-methionine, a cobalamin cofactor, and a reductant (the reductant does not show in the overall reaction because it is being restored during the cycle). The reaction is initiated by formation of 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen atom from C2'. The enzyme is also able to catalyse the radical mediated, stereoselective C2'-methylation of dAMP.",384,0.99999994,-0.11720576,-0.04228831,-0.08832651,0.04678707,0.035546225,-0.010336549,-0.079845764,0.03120885,0.06862278,-0.016564304,0.036670703,0.023097498,-0.00015454195,0.009225283,-0.035777714,0.13498428,-0.04700043,0.058274686,0.002379029,-0.030680003,0.030518817,0.010075512,0.012180309,-0.019301841,0.060455553,-0.017051658,0.05411422,0.08397475,-0.06403661,-0.0630534,0.06637554,-0.025073115,0.024698956,-0.07326946,-0.040170863,0.05734137,0.0010273323,-0.061607547,0.10781036,0.0057288357,-0.031564772,0.015553615,-0.0035510065,-0.014541614,0.037575863,-0.05748379,-0.06283248,0.045045648,0.0008278986,9.470239e-05,-0.042322878,-0.030189963,-0.040234488,0.016192222,0.039086398,-0.007253759,-0.02926166,-0.011743488,0.012468717,0.001851442,0.08955368,-0.012646187,-0.06265069,-0.021935694,-0.067256466,-0.009722646,-0.0042819665,-0.07423219,0.045138646,-0.023947233,-0.075795636,-0.09406769,0.041464888,0.0110827675,0.0068163923,-0.051595863,-0.07734456,-0.023397902,0.0057951408,-0.01541946,0.07727673,-0.0076180114,-0.02415448,0.06689406,0.064588316,0.005424959,0.06903429,-0.007930197,0.05494996,0.070087284,-0.042329904,-0.0038564124,-0.08992052,-0.05761256,-0.079232216,-0.06577076,0.021321705,0.10173907,-0.062538534,0.030178783,-0.019325834,0.06693135,-0.008144541,-0.055641066,-0.033717297,-0.008167176,0.030634785,0.07346347,0.0461456,0.00015200139,-0.013639778,-0.008465305,-0.02108722,-0.0374349,-0.03239278,0.11042018,0.029608548,-0.051164765,-0.09884135,-0.04947889,0.062253874,0.016822334,0.00878849,-0.015466989,-0.0016110991,-0.0072772317,-0.070863605,1.5890571e-33,0.09547423,0.07542239,-0.035046183,0.0027266238,0.0043107388,-0.032220338,-0.12242718,-0.015726855,0.022700975,0.0034413415,-0.063861385,-0.0661798,0.015072809,0.0006479621,-0.030038936,-0.06336309,0.008249436,-0.05026612,-0.01666397,-0.010636955,0.007937511,0.0047202804,-0.10917397,0.024881573,-0.0113692535,0.019374881,0.008038133,0.0109966425,0.06578349,0.033412788,-0.04325609,-0.022659652,-0.09434628,0.0070555327,0.009860555,-0.0028814585,-0.094365455,-0.061397225,0.115345016,0.036729354,0.038983546,-0.015785085,0.02591286,0.036049694,0.046576742,-0.0070139803,-0.015886351,0.15121196,0.11682833,0.07542963,0.053434186,-0.053176597,0.08615617,0.027028471,-0.09155955,0.010091019,-0.051281832,0.0032125276,-0.021511458,0.07952615,0.010790451,-0.07508319,0.003474109,0.00405747,-0.03783199,0.015833765,-0.078099415,-0.062131096,-0.008040434,0.026509136,-0.02056694,-0.015218043,0.13416266,0.05479038,-0.018862596,-0.0028291526,0.033062227,0.062996335,0.08384274,-0.012112681,-0.07216587,-0.044887442,-0.0027284282,-0.007375724,-0.0016417189,0.026083037,-0.013784125,-0.025543185,-0.050256323,0.037302464,-0.013467916,-0.056993484,-0.0556499,0.01117367,0.05482494,-3.848159e-33,0.086320296,-0.068948284,-0.006328646,-0.095839806,-0.04429996,0.036763772,-0.03425871,0.021376468,-0.022683894,-0.03443024,0.061372407,-0.015316645,0.00016608302,-0.028241558,0.053892355,-0.01153439,0.015237684,0.052919928,-0.049987677,-0.013595397,0.054524865,0.06636458,0.018597137,-0.009909719,0.06484215,0.028637886,0.029127598,0.027392898,0.05278635,0.10582283,-0.021976192,-0.029585259,-0.0460409,-0.0055137263,0.018791202,0.14414446,-0.0124431625,-0.0033391595,-0.065497935,0.03934089,-0.0071836226,-0.035299234,-0.018013904,0.08118999,0.12439837,0.06661301,-0.047504943,-0.0007512492,-0.0025729255,-0.11909773,0.093499094,0.049885765,-0.021481372,0.01916979,-0.028983604,0.08306375,0.052817278,-0.053836025,-0.012748731,-0.05849923,-0.07358157,-0.017143056,0.05906189,-0.034713794,-0.03824392,0.040401775,0.033566214,0.014081337,0.072217055,-0.029226823,0.013013318,0.024585076,-0.0017064236,0.018928891,-0.017918348,-0.051960286,-0.06734398,-0.08482969,-0.03804779,-0.028510703,-0.035611127,-0.022897718,0.029321553,-0.033316907,-0.04629482,-0.07188116,0.010594426,0.061479647,0.014315134,0.0443464,-0.011084615,0.04193189,-0.061968084,0.047461137,0.019582342,-4.904972e-08,0.030111626,-0.041592885,0.05702546,-0.023023626,0.020795839,0.07303796,-0.0010777127,-0.0003125388,0.014482898,-0.037011843,-0.04724837,0.14249395,-0.034021515,0.020816332,-0.030323882,-0.0038103084,-0.039988197,0.055658862,-0.041695338,-0.022057014,-0.04570792,-0.032903995,-0.055190984,0.046947427,0.022598898,-0.027391676,0.028506627,0.046769686,-0.0063673463,-0.034512866,0.09357126,0.036942985,-0.07081724,-0.016814902,-0.12200679,0.014915641,-0.02330859,-0.022205943,-0.008933624,0.0033727083,0.023595478,-0.051209185,-0.12962969,0.09801515,0.046027645,-0.0063031595,-0.033110317,-0.049149696,-0.032220434,0.029551502,0.078248896,-0.009171421,-0.006640262,-0.020364711,-0.11132953,-0.0055437414,-0.023979874,-0.045800425,-0.015172661,-0.03360343,-0.028806556,0.05795857,0.15675311,-0.008352778 +5.5.1.37,"The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), is a carboxylesterase-like cyclase that catalyses a regio- and enantiodivergent [4+2] cycloaddition reaction to generate the iboga scaffold of catharanthine. cf. EC 5.5.1.38, tabersonine synthase.",384,0.99999994,-0.04502022,-0.013080797,-0.14794119,-0.04099417,-0.0085844565,0.068325885,-0.051917195,0.018858446,0.0069316123,-0.0024261905,-0.010353156,-0.06514907,-0.022121282,-0.0077862344,-0.09157596,0.09423945,-0.05996682,0.056214865,-0.0021276996,-0.047057424,0.058132775,0.04375825,0.04738052,0.03502753,0.03155296,0.047220554,-0.041619837,0.001671955,0.004278234,-0.024179213,-0.021300334,0.028782025,0.025541749,-0.028072111,0.05844229,0.05945333,-0.070394695,-0.014015432,0.07276098,-0.003467228,0.019505445,0.001277984,-0.028380865,-0.053949345,-0.020573575,-0.006992334,0.040611845,0.02307261,-0.009628249,-0.08368744,-0.029938402,-0.07915545,-0.022642434,-0.039507695,-0.027485117,-0.065500826,-0.05668849,-0.0036507894,-0.011864965,0.036431283,0.07319607,0.03438432,-0.0077914186,0.022890138,0.017969716,-0.051583596,-0.072536275,0.0028749288,0.06491292,-0.06530825,0.0034319016,-0.07853872,-0.07557285,0.009248247,-0.059956923,0.054974396,0.01575603,0.0009310304,-0.007207756,0.0077925143,0.005124575,0.015444483,0.08685781,0.095369935,0.082440056,0.069790825,0.063208334,0.04982184,0.065683156,-0.00423242,0.0912356,-0.035811897,0.0029414846,0.011397185,-0.0607044,0.029534264,0.0060096383,-0.022306917,0.038233265,0.019057274,0.022823546,0.016602306,-0.027834596,-0.04942246,-0.07273293,0.0068612983,0.021979572,0.08471808,0.020499188,-0.021838272,-0.035092723,-0.074521296,0.027116623,0.05233986,0.01574015,0.083635524,0.0019574245,0.0048627118,-0.008915985,0.040300958,-0.0015964234,-0.010297354,-0.049831215,0.045229647,0.0046095033,0.07928766,-0.13425966,4.0562593e-33,0.076547906,0.09366379,0.037890058,-0.040181693,0.03719046,-0.018978726,-0.09193758,0.06075245,-0.085840486,0.006448997,-0.10438454,-0.010614844,0.012022554,-0.03612858,0.0073176757,-0.034346774,-0.06620126,0.005576295,0.043446768,-0.02217356,-0.010765167,0.0628974,-0.090865076,0.013960871,-0.0538808,0.074842416,0.060007624,-0.059202373,0.035364114,0.02044332,0.03648354,-0.08397169,-0.105388,-0.008790595,-0.0385815,-0.0761003,-0.027691258,-0.06803389,8.1527745e-08,0.08594417,-0.029105084,-0.0042796573,-0.02563449,-0.035846032,0.070762955,-0.036490496,-0.0007703131,0.14166506,0.06685601,0.038545344,0.054705735,0.015220671,0.12954035,0.014591056,-0.10288834,0.07985581,-0.012335575,0.015954787,0.08207893,0.07334805,-0.02777855,0.008401553,-0.017288368,-0.009380183,-0.0025437458,-0.017282793,-0.016704893,-0.06772786,-0.009785868,0.03767317,-0.07624624,-0.03726841,-0.0014455135,0.030800661,0.08327253,-0.06498914,1.44406995e-05,-0.0013054425,0.026758898,0.0065950365,-0.047095872,0.011188305,-0.03200453,-0.029856537,-0.0064326115,-0.052220482,-0.04485594,-0.007667893,-0.066024296,0.0704291,0.0623073,-0.036991265,-0.07468985,0.0427347,0.028003078,-2.9985223e-33,0.048590604,-0.1091457,-0.01500035,-0.071749516,-0.041673712,0.051250257,-0.019474782,-0.013329739,0.027874202,0.03712611,0.0014989991,0.010650507,0.14777084,0.01459596,-0.060192645,-0.065387495,0.028285619,0.02404726,-0.0029031977,-0.030408287,-0.02335914,0.117603876,0.018684974,-0.017003465,0.005063661,0.041916072,-0.015917651,0.077097565,0.05496859,0.046104338,0.049480166,-0.037952933,-0.02045549,-0.060073704,-0.06751508,0.08627429,-0.014159611,-0.04496002,0.017915066,0.05681566,-0.05099816,0.03727501,0.0005314894,0.06518734,0.095696166,0.022980504,-0.05948025,0.056572355,-0.010155155,-0.03898779,0.022785198,0.058427,0.021643952,0.004765122,0.062687516,0.017455824,-0.017610205,-0.048305523,-0.07242473,0.028988972,-0.0028653075,-0.057904795,0.03018422,0.008113984,0.02063351,0.07505959,-0.0027258627,0.051436644,0.047306772,-0.008972398,0.11088203,-0.024888797,-0.04225384,0.062854595,0.006157701,-0.011072199,-0.011675614,-0.06729808,-0.0038513695,-0.10794494,-0.041909754,0.0027924033,0.06806924,-0.057133585,-0.04467361,-0.08805274,0.03513751,0.13856292,0.018173613,0.035052508,0.042086862,0.022197593,-0.001984797,0.086612545,0.07663306,-4.03461e-08,0.03216039,-0.06336846,0.057154335,-0.017739657,-0.0029865273,-0.023741584,0.016910734,-0.010755613,0.023892464,-0.086359866,0.011540011,0.02515758,0.02376634,0.018443346,0.054584593,0.048635844,0.09085674,-0.023164926,-0.051654268,0.009482942,-0.013469802,0.02667009,-0.08031735,-0.042760767,-0.03559277,-0.103426374,0.018901147,0.03401616,-0.03661074,-0.0129389195,0.0057212,0.023385875,0.022112472,-0.03892225,-0.10562788,0.06450327,-0.03519335,-0.082518175,0.041283436,-0.07865816,-0.0036271913,-0.10836739,0.0090062255,-0.023325497,-0.028261682,0.021510152,0.0066751386,-0.06164225,0.00608454,-0.045086976,0.013280698,-0.010490398,0.044405207,-0.044870865,-0.049474493,0.052785892,-0.02671027,-0.058860477,0.030502722,-0.06864495,-0.019178266,0.026748724,0.16916671,-0.049309786 +5.5.1.38,"The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), is a carboxylesterase-like cyclase that catalyses a regio- and enantiodivergent [4+2] cycloaddition reaction to generate the aspidosperma scaffold of tabersonine. cf. EC 5.5.1.37, catharanthine synthase.",384,1.0,-0.049339574,0.036858007,-0.15282051,-0.025544705,-0.01597048,0.06870367,-0.04541227,0.0028963499,-0.012895242,-0.01913068,-0.007193288,-0.07791911,0.017466487,-0.01079898,-0.11028548,0.080307096,-0.029001435,0.05345402,0.014135872,-0.023972975,0.045779027,0.032223392,0.026412854,0.015819019,0.04166301,0.050181456,-0.053137597,-0.065328486,-0.058365006,-0.06143582,-0.027226796,0.012892096,0.005764722,-0.032445535,0.06167803,0.06597704,-0.0684403,0.031632952,0.07111783,0.034240846,0.034178387,-0.023554768,-0.040314432,-0.038024843,-0.05818989,0.014599957,0.023083083,0.02555904,0.029286621,-0.08328984,-0.06723832,-0.051165268,-0.06019879,-0.051355224,-0.05768333,-0.02784244,-0.062246725,-0.019935925,-0.046432618,0.0108486395,0.037731178,0.036405742,0.0048418827,0.0377289,0.029216617,-0.056933004,-0.07494629,-0.018530063,0.08773717,-0.041008644,0.010933235,-0.06592075,-0.033305965,0.0074557355,-0.029779557,0.054377176,-0.0009817146,0.03181165,0.0148977665,-0.036859665,0.0133565655,-0.011437718,0.0617417,0.10354163,0.0647421,0.067958154,0.08172378,0.048809342,0.075097814,0.0339855,0.09643467,-0.02058408,-0.023834733,0.00831325,-0.057196446,0.01340813,0.030333241,-0.012876166,0.027335543,0.00085997646,0.0103344405,0.004725109,0.00969935,-0.035742927,-0.06420041,-0.037499532,-0.008159006,0.0075601125,0.046449304,-0.037013136,-0.019438043,-0.09734472,0.030321991,0.014752327,0.010091421,0.103893474,-0.008545169,-0.03368893,-0.01181741,0.032360945,0.001550376,-0.038659945,-0.05007196,0.05362745,0.035280395,0.09474269,-0.17347117,3.5487164e-33,0.062086698,0.0789849,0.048358276,-0.028335905,0.053210903,-0.014369,-0.06859627,0.038572058,-0.062824234,-0.020598292,-0.07795423,-0.04711101,-0.007789852,0.008119696,-0.014070009,-0.03529345,-0.04472203,0.0075978446,0.020137906,-0.035547473,-0.04533341,0.0524935,-0.06900796,0.021269899,-0.03776115,0.07642836,-0.0014217459,-0.036991857,0.06552718,0.032463305,0.058752008,-0.08921162,-0.10600498,-0.00038588681,0.017472008,-0.030259954,-0.042599034,-0.07198885,-0.0029945693,0.073639974,-0.057265233,-0.0014859248,-0.014152565,-0.037063867,0.027045866,-0.073741555,-0.0015998482,0.13354796,0.078265116,0.015751297,0.06858551,0.027809402,0.1437239,0.04206861,-0.068777435,0.07136693,-0.04242117,0.030576505,0.051965646,0.07220261,-0.02148779,0.04216903,-0.054515474,-0.024443243,0.008121252,-0.014422195,0.0052470355,-0.033248655,0.0036591864,0.02752525,-0.022106558,-0.034290534,0.02277178,0.04140059,0.06585366,-0.021575527,0.0416905,0.0183774,0.008753138,-0.010036959,-0.014831293,0.031372394,-0.039252106,-0.064588286,-0.037583467,-0.024492668,0.038035434,-0.0022372121,-0.07180042,0.093817055,0.041834015,-0.032985397,-0.06534823,0.007597385,0.017074559,-3.3687328e-33,0.030756336,-0.12987514,0.013209845,-0.09600277,-0.044879597,0.08370158,-0.010242313,0.0037974617,0.035444748,0.006175434,-0.027368829,0.036986895,0.15621138,0.009634156,-0.043453164,-0.046034604,0.01109498,0.03374048,-0.0062160213,-0.022531234,-0.0025246656,0.1297039,0.003658193,0.03376869,0.021873,-0.013854894,-0.025564179,0.0929581,0.021923069,0.029813668,0.06343,-0.042302325,-0.041911863,-0.048267063,-0.07716183,0.09074438,-0.029513942,-0.008400008,0.017358754,0.049958754,-0.076528676,0.010386605,0.020416534,0.056181766,0.109584235,0.018411113,-0.06368222,0.057778925,-0.018189505,-0.039901763,0.0126665365,0.03441634,0.029634701,0.0043650367,0.04789276,0.02730287,-0.015367071,-0.0067189727,-0.06239838,-0.02257152,-0.008871166,-0.08616893,0.018908657,0.017898295,0.027330894,0.06546942,0.004122189,0.010123828,0.01924837,-0.00273072,0.070715375,-0.014951127,-0.07854453,0.062237423,0.023094736,-0.024901712,-0.017516209,-0.025037538,-0.001684146,-0.073736005,-0.04401378,0.006779525,0.07026311,-0.09287589,-0.033206873,-0.060599547,0.06227241,0.13782156,-0.008513356,0.03338879,0.027371231,-0.010504252,-0.041950554,0.08463718,0.087266654,-3.9641844e-08,0.045560718,-0.04874143,0.07184573,-0.050131343,0.02568061,-0.024997316,0.03348276,-0.02201754,0.012239505,-0.10828659,0.017508073,0.024944974,0.040410116,0.010122731,0.0852333,0.018701259,0.08768837,0.031626936,-0.04333904,0.013023132,-0.033517774,0.04622756,-0.0772962,-0.0226037,-0.024106586,-0.06507277,0.061803244,0.00025934956,-0.08042691,0.00021502298,0.028747637,0.006866468,0.03848336,-0.07152675,-0.098775364,0.026067104,-0.021332685,-0.08620945,0.053541124,-0.0029970165,0.023926489,-0.051070303,0.017959785,-0.013706826,-0.07194029,0.010922293,-0.00028174362,-0.057795614,-0.021781197,-0.015486982,0.014156357,0.015460187,0.013323164,-0.078842826,-0.052034486,0.025521124,-0.017434528,-0.05932122,-0.012187256,-0.041668955,-0.029155426,0.042017136,0.20092176,-0.02807702 +6.3.1.22,"The enzyme, charactrized from the bacterium Bacillus subtilis, catalyses a similar tRNA modification to that performed by EC 2.3.1.193, tRNAMet cytidine acetyltransferase. However, unlike that enzyme, which uses acetyl-CoA as the acetyl donor, this enzyme activates an acetate ion to form acetyladenylate and then catalyses the acetylation through a mechanism similar to tRNA aminoacylation.",384,1.0,-0.09727109,-0.025286589,-0.099737614,-0.056417167,0.005634121,-0.020950355,-0.036076352,0.02760281,-0.0032871065,-0.03372002,0.079885036,-0.07801314,-0.01621204,0.0038225946,-0.06958035,0.0240682,-0.09065332,0.02274665,0.032127004,-0.09459847,0.046725515,0.052477103,-0.07583728,-0.027628032,0.012072304,-0.0022734,0.044311855,-0.081306085,-0.02964034,-0.052364007,-0.06617773,-0.06624364,0.06262788,-0.037980672,0.030056203,0.0390057,-0.08804279,-0.014666313,0.12388387,0.050632406,0.0026771897,0.01305213,-0.036508244,-0.046380315,-0.016908843,-0.045062147,0.0754363,0.007483347,-0.05153783,0.008279864,-0.029311584,0.025508163,-0.022997998,0.012906424,-0.0053487276,0.034228466,-0.041122824,-0.035634167,0.014913983,0.003730578,0.05943098,0.028756572,-0.0037525934,-0.04788967,0.04165872,-0.1038767,0.05517499,-0.07498947,0.041281007,-0.062594,-0.048643846,-0.048407126,-0.055998273,0.09718697,0.035030056,-6.623887e-05,-0.033234328,-0.021142842,0.0021084559,0.027172225,0.0066995723,-0.03466792,-0.02266159,0.054755665,0.08493724,0.030902272,-0.018578548,-0.016005086,0.02347653,0.061840296,0.067236654,-0.039212786,0.00778347,-0.06725024,-0.08067267,0.0066720764,0.021406021,0.06075104,0.09363848,-0.010284291,-0.012219211,0.097469494,-0.048019335,-0.051773928,-0.047940664,-0.043221448,0.0893023,0.06430309,0.036242995,0.025265617,0.007936328,-0.0043124114,0.04201521,-0.06820555,-0.013182183,0.116236724,0.0012597527,-0.022213226,0.018293276,-0.026124662,0.026833223,0.008764404,0.06503883,0.08922788,0.013076814,0.08609097,-0.112697214,3.4997108e-33,0.010824024,0.03630328,0.037160095,0.040209908,0.045759395,-0.040204845,-0.07678126,0.0069695534,-0.02299,-0.077136226,-0.07103014,-0.08236313,0.031125292,-0.0030434493,-0.009428668,-0.009125333,-0.08285701,-0.019481491,0.043404453,-0.0034277372,0.022381013,0.042949166,0.03266767,0.05035376,0.06473967,-0.01185826,0.022738067,0.036266085,0.063658625,0.0077740154,-3.559702e-05,-0.048490766,-0.06733852,-0.044611067,0.033779304,-0.020001363,0.007991455,-0.04735448,-0.05755945,0.07746898,0.021653734,0.021302368,0.03666494,-0.01746669,-0.0019619286,0.021705309,-0.025612477,0.07566038,0.008871164,-0.007382511,0.024186373,-0.023543091,0.06483374,-0.014578421,-0.010637149,0.059258964,-0.005486866,-0.02471489,0.058959477,0.07316547,0.01717635,0.02233892,0.01951114,0.064561754,-0.06405205,0.03549583,-0.035635423,-0.04862081,0.039279323,0.06403884,-0.096477635,0.00885235,0.081744015,0.017816784,0.04094044,-0.02913937,-0.07799126,-0.033196904,0.0025796152,-0.053482164,-0.051456954,-0.021034218,0.07809485,0.006555079,0.0006474758,-0.045097865,-0.008956763,-0.06825229,0.026034879,0.047801863,0.036465373,-0.06612254,-0.08873153,0.055050235,0.029963614,-4.1555676e-33,0.09450322,-0.13228332,0.028897565,-0.10561809,-0.11033898,0.018268485,-0.018081386,-0.052145015,0.0030431238,-0.028256191,0.06522861,0.008651424,-0.005637987,-0.0013429495,0.04995834,-0.04803339,0.057828676,0.000868232,-0.04722037,-0.022497695,0.016004046,0.033696853,0.02681695,-0.032491952,0.031731535,0.019198848,-0.027212724,0.1202311,0.08995462,-0.020145874,-0.06861996,0.011948838,0.012730504,0.0067402674,-0.09815127,0.11935099,0.021078981,0.03918581,0.013755801,-0.010168478,-0.01185138,0.00056641485,-0.019669069,0.04278601,0.00774278,0.07136643,0.017914033,-0.026402663,-0.01770164,-0.10140742,0.13348949,-0.010568189,0.008020657,-0.04929526,0.060398977,0.054563377,-0.011937454,0.010350381,0.023874547,-0.022965133,-0.04813849,-0.052515984,0.01729934,-0.04126173,0.058244,0.0150071895,-0.031680822,0.055662546,0.033634525,-0.045481306,0.011600492,-0.029977627,0.041522924,0.054264735,0.0051829405,-0.04191149,-0.0781727,-0.04807732,-0.01177251,-0.074487634,-0.05137001,-0.08374109,-0.03004959,-0.02190942,-0.010998403,-0.021128742,3.0110517e-05,0.110171355,-0.02009797,0.04871732,-0.057969153,0.04069793,0.023817532,0.011163765,0.016571607,-3.956964e-08,0.0029350356,-0.062826395,-0.00087054924,0.00022025341,0.03474735,0.07037532,-0.062143676,0.016420769,0.07031546,-0.07933551,-0.06212288,0.09386118,0.031094017,0.055319656,0.014626664,0.06690024,-0.08352195,0.0057678334,0.015436816,-0.030433964,-0.12323468,0.059436496,-0.15704253,0.018194152,-0.008321277,-0.05501151,0.044654585,0.10497302,-0.038709514,-0.0507317,-0.008949472,0.0031984232,0.004096193,0.03201213,-0.034319405,-0.00058731483,-0.012523473,-0.058325905,0.011291823,0.042467177,0.028096702,0.018044865,-0.15619554,0.0292287,-0.03131552,0.03582945,-0.057726223,0.051801935,-0.014222738,0.0019631349,0.06904231,-0.0048891343,0.05658194,-0.013664871,-0.026117282,-0.0030069698,-0.00903692,-0.07878684,0.033481076,0.05828267,0.029989304,0.010870388,0.18087253,0.0020178389 +1.1.1.441,"The enzyme, present in all eukaryotes, catalyses the dehydrogenation of ditrans,polycis-polyprenol and the reduction of dolichal as part of the pathway that converts ditrans,polycis-polyprenol to dolichol (cf. 1.3.1.94, polyprenal reductase). The enzyme works equally well with NAD+ and NADP+, but due to the cellular ratios of NAD+/NADH and NADP+/NADPH, the enzyme catalyses the oxidation of of polyprenol using NAD+ as the electron acceptor, and the reduction of dolichal using NADPH as the electron donor.",384,1.0,-0.052657984,0.040657844,-0.038025204,-0.0028659499,0.040224954,0.010209558,-0.08172347,0.046524473,0.05711423,-0.01667702,-0.01266739,0.013029492,-0.11094978,0.0021361413,-0.033653278,0.06254884,-0.054941464,0.060072377,0.018070115,0.002170316,0.045104403,-0.09997779,0.0036873585,-0.02930869,0.076266505,0.053518593,0.018106647,-0.019243171,-0.04032436,-0.03611422,-0.030646317,0.000162631,0.010453543,-0.046324126,-0.029962923,0.09376919,-0.073546425,-0.015829384,-0.048774842,0.0054809116,0.03971281,0.004849531,-0.046988204,0.007469729,-0.08207876,-0.0010949249,-0.03759061,0.07592918,0.015235123,0.006427076,-0.059570212,-0.022874437,0.0757522,-0.0011238746,0.043021895,0.05802397,0.025560966,0.013975002,-0.02448081,-0.061298985,0.007853981,-0.007888315,-0.11700228,0.018970521,-0.031821158,-0.0071371705,0.038029324,-0.060560565,-0.034016524,-0.03412543,-0.09998296,0.036069818,0.043501653,-0.01571965,-0.047581457,-0.015305587,-0.021505304,0.0048498325,0.032980245,0.01761657,0.06026625,0.016277649,-0.028304018,0.059006743,0.0579648,0.07716967,-0.021104107,0.0024094484,-0.020343551,-0.0007096224,-0.040012777,0.0046824934,-0.01755584,-0.00563214,-0.0898161,0.08822744,0.07338776,0.061155744,0.036253143,-0.031394795,0.026043555,0.035926566,-0.0010894769,-0.12222408,-0.0974441,-0.0044717086,-0.031412154,0.07505752,-0.010357644,0.018506128,0.043539073,0.02681339,0.07314659,0.022532593,-0.0513511,0.08368043,0.023806667,-0.05457841,-0.08130073,-0.069656715,0.005668532,-0.038046315,0.020802198,0.098188005,-0.0021535435,-0.041026797,-0.09607972,1.7284834e-33,0.10096214,0.00895011,-0.023780035,0.025720965,0.017839966,0.018194737,-0.028475493,0.001201343,-0.0735653,-0.03348746,-0.063256994,-0.078431875,0.025399836,0.0081176525,0.052752133,-0.03121252,0.060328,-0.036887366,0.08127238,0.03316262,0.07860858,0.047672328,-0.044329762,-0.0043014246,-0.0067453743,0.082028,-0.0006433392,-0.011749732,-0.037336465,-0.013784129,0.07083679,-0.11975297,-0.08314877,0.09349565,0.04338139,0.024310917,-0.078094214,-0.031809628,-0.022870444,0.032591194,-0.05324973,0.03645494,-0.047892958,-0.0482891,0.0737552,-0.061048437,0.026904834,0.038534895,0.06312428,0.08228743,0.060773093,0.011041055,0.06665012,-0.026347263,-0.11587645,0.04398576,-0.010788731,-0.035308164,-0.009275781,0.08590778,-0.0068089315,0.043217234,-0.06713588,0.0029801817,-0.028015696,0.02468428,-0.031169407,-0.057907566,0.021991098,0.049420692,-0.041578967,0.01930109,0.04602827,0.035952073,0.00035731195,0.015666328,-0.013576448,0.068411745,0.06655645,0.0024779867,0.05120762,0.016483003,0.008792169,-0.044946063,-0.0072063254,0.011106139,0.00023912055,-0.057774253,-0.0053381054,0.016220775,0.044831634,-0.16500501,-0.024447473,-0.03922442,0.048175007,-4.2393263e-33,0.056411583,-0.087803714,0.04119063,-0.062300954,-0.059859995,0.12158677,-0.00043648016,-0.040510476,0.021929532,-0.040134724,0.02452799,0.03472221,0.022639088,-0.01633082,0.0013734146,0.00041299418,-0.015994545,0.055779792,-0.04918241,-0.07036017,0.014533684,0.14731543,0.027388334,-0.026039014,0.033273015,-0.038688,0.025882496,0.049534798,-0.004454266,0.022686046,-0.033427145,0.012828684,-0.04047138,-0.0033643746,0.029233932,0.018720057,-0.17663176,0.05755619,0.03392881,0.07539603,-0.085916676,-0.044371158,0.010693697,-0.021310423,0.008688386,0.046777256,-0.19272804,-0.024514463,0.072485775,-0.051729944,0.04508719,0.057855707,-0.01356421,-0.002558855,0.05214324,0.022033669,0.0325465,-0.012739542,0.010839749,-0.047924865,-0.07504476,-0.08080903,0.07817729,0.06603974,0.014254405,0.062484685,-0.012524564,0.034429558,-0.011445905,-0.04545312,0.039177533,0.03282528,0.006547631,0.074562654,-0.010205247,-0.088851325,-0.086263664,0.035366282,-0.007373589,0.037449483,0.008232389,-0.02283655,-0.037453737,-0.10304583,0.016988114,-0.07169543,0.084389314,0.06327552,-0.05023317,0.0072508063,0.031407505,0.06730127,-0.04306722,0.039624333,0.13170947,-3.9788414e-08,-0.0151493605,-0.020743392,-0.02050981,-0.023965798,-0.022920286,0.020680629,0.026046904,-0.00011607193,0.005487389,-0.030941157,-0.016672831,0.11946174,0.012362986,0.027560974,0.0380017,-0.009905609,-0.010820016,-0.056478262,-0.017633058,-0.0014428169,-0.018132603,-0.010267577,-0.09401458,0.028693233,0.053687688,-0.07679274,0.022556558,-0.03181313,0.011117734,-0.023260001,-0.029780589,0.032161873,0.026914528,0.0024518666,-0.03253761,0.062529065,-0.012017058,-0.015624314,-0.024139749,0.07384665,-0.010044318,-0.085136816,0.008535583,0.046262976,-0.049543872,-0.0047149835,-0.004100136,-0.020548245,-0.01637079,0.04733823,0.06678372,-0.008270056,-0.0060592177,-0.11087247,-0.10639145,0.05326292,-0.03564329,-0.022298867,-0.044182535,-0.019892579,0.043449532,-0.018033793,0.14439106,0.0021925115 +1.5.1.57,"The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine. It belongs to the family of medium-chain dehydrogenase/reductases (MDRs). The enzyme forms an aldehyde group at C-17, which results in spontaneous cyclization. In vitro the enzyme can also act on norfluorocurarine, but more slowly.",384,1.0,-0.03848856,-0.017813982,-0.20678838,-0.07264985,0.054935835,0.0063805585,-0.124817275,0.00218925,0.08403995,-0.03920856,0.021292321,0.0020781823,-0.07596622,0.014973373,-0.06756258,0.027634833,-0.12892148,-0.044776686,-0.012035388,-0.07938281,0.02275524,0.103257716,-0.020995412,0.0039963247,0.03859459,-0.03212847,0.009809768,0.00022182876,0.0033800788,-0.06440319,0.106081635,0.03226067,0.039320808,-0.070420094,0.042090558,0.076429926,-0.06251001,-0.054572858,0.046901822,0.030011524,0.020953994,0.011521182,-0.039203737,0.007383683,-0.10272889,-0.029678158,0.004325872,0.08711205,-0.01213851,0.017604234,0.005835541,-0.06669802,-0.031616185,0.042839784,0.032188505,0.06665508,-0.07887421,-0.026212601,-0.036607042,-0.010859313,0.043326434,0.022127189,-0.011246057,0.014896745,0.00057753175,-0.0018517097,0.0647737,-0.042832512,0.044890106,-0.08665425,-0.029245615,-0.089417644,-0.029419165,0.008806926,-0.04144813,0.055623855,0.0022762343,-0.014628642,-0.003715816,-0.00049552025,0.05696946,0.020780923,0.0527625,0.08051095,0.06765514,-0.016580667,-0.03053499,0.034513667,0.045228094,0.0420642,-0.018772608,0.011440328,-0.041685358,-0.04214475,-0.060814336,0.003335257,-0.003778234,0.029624531,0.025346668,-0.021173598,0.011683693,0.032737255,0.038549796,-0.023177441,-0.07187569,0.033913452,-0.050572228,0.05235552,0.02865965,0.028345678,-0.013380336,0.10178096,0.029555941,-0.021381529,-0.01616779,0.04393555,0.032368258,-0.08599448,-0.05767239,-0.026229464,0.0074783205,-0.015277562,-0.0065496964,0.053631257,0.07442442,0.024859384,-0.16116914,9.181255e-34,0.02449348,0.06707502,0.05250226,-0.038691852,0.06476147,-0.014237565,-0.014585728,0.036649045,-0.047913484,-0.031240946,-0.07663717,-0.09489078,0.04059352,-0.08222872,0.06271343,-0.039515544,0.00635859,-0.014902458,0.016791027,-0.017943066,-0.015154194,0.14357974,-0.10134224,0.008627345,0.023149652,0.07328802,-0.0475181,-0.008210384,0.04935353,-0.02723391,-0.018307725,-0.06582686,-0.07929818,-0.0066474495,0.0977033,0.014806421,-0.07695942,-0.06259015,0.041085295,0.04510785,0.026044777,0.01913803,0.036290146,-0.008385485,0.019884063,-0.04083798,-0.09949856,0.031115752,0.03532156,0.029395035,0.008678141,0.007912345,0.059593476,0.0070990566,-0.040455226,0.019228654,-0.053290732,-0.028616715,0.0087529365,0.08122108,-0.023176,-0.015479733,-0.04846466,0.031710275,0.035393585,-0.06345742,-0.049812246,-0.08565797,-0.017958641,0.07244018,-0.04475988,0.0024158135,0.045173634,-0.07332157,0.0218896,0.03205764,-0.040175207,0.013759122,0.06163796,-0.009477642,0.014464855,0.0016989226,-0.035461504,-0.050152905,-0.050063904,-0.022582168,-0.0059406916,-0.07075742,0.013011128,0.09311229,0.02391496,-0.103175536,-0.0726572,-0.037572503,0.05473823,-3.3292685e-33,0.071452886,-0.10721812,0.0504585,-0.052045103,0.027130846,0.09162424,-0.018971687,-0.005944101,-0.030863268,-0.059903488,0.045766443,0.018880788,-0.027873537,-0.04042704,0.010102709,0.03692072,0.068829946,0.16948044,-0.025525458,0.02950396,0.03372855,0.07976595,-0.00045964215,0.04514327,0.004302688,-0.029655842,0.046351478,0.039230797,0.06643361,0.067421086,-0.004200959,0.026885092,-0.03226363,-0.053845838,-0.008264464,0.07122249,-0.06010761,0.0139116915,0.038618863,0.005741909,0.015933791,0.043331664,0.024177054,0.055633236,0.0090827495,0.042020526,-0.07882111,0.048308004,-0.040805306,-0.04414081,0.06709392,-0.0013558462,0.032605533,0.06576195,0.032005478,0.043999534,0.06382393,-0.061352767,-0.012845697,-0.025563562,0.014266785,-0.019133842,-0.1088759,-0.033955548,0.03568552,-0.058446903,-0.04703684,0.03823968,0.060025763,0.017772608,0.04149577,0.043447997,-0.022099202,0.08684044,-0.052135702,-0.035647936,-0.07099678,-0.039011635,0.0068216133,-0.043718666,-0.046053547,0.0001544929,0.04246142,-0.07560094,0.027427174,-0.112725206,0.09723841,0.023565669,0.0005053971,0.019598324,-0.019804932,-0.010147617,-0.041328073,0.07497159,0.011303281,-3.8021152e-08,-0.029197672,-0.058380414,-0.030589402,-0.07169563,-0.012139389,0.0005569151,0.064757206,-0.015318257,0.018872624,0.036148325,0.033187397,0.02366098,0.049393084,-0.06749189,0.05238643,0.0432918,-0.034665596,0.014630502,-0.003143107,-0.021932663,-0.009466907,0.05810399,-0.11699132,0.041099355,-0.043382756,-0.0068078456,0.042129032,0.07289418,0.048369166,0.038100887,0.041129164,0.04541135,0.06709618,-0.04553501,-0.08787986,-0.025261302,0.033174448,-0.029597366,0.048822064,-0.018979002,-0.030261064,-0.023177363,-0.08739415,0.03490781,-0.04571957,-0.010747386,-0.017902948,0.0005722274,0.0057834624,0.003952746,0.04268707,0.029527491,-0.0082142195,-0.033816352,-0.061701372,-0.032679554,-0.015017904,-0.029121382,0.012075681,-0.09011509,0.027689297,-0.017942024,0.18450056,-0.021086192 +1.5.99.16,Contains FAD. The enzyme from the bacterium Azospirillum sp. B510 reacts about tenfold less efficiently with 2-(ethylaminoethyl)phosphonate and about 400-fold less efficiently with (2-aminoethyl)phosphonate. Oxygen is used poorly as an electron acceptor (at least 50-fold less efficiently than the artificial acceptor DCPIP). The physiological electron acceptor is unknown.,384,1.0,-0.1366238,-0.015588522,-0.06332791,-0.042926013,0.04856272,-0.015208169,0.016771201,0.06711816,-0.016520862,0.07527053,0.008989846,-0.04120137,0.040321387,0.043385282,-0.012144177,0.087676644,-0.03255278,-0.035234515,-0.030122498,0.017609803,0.03649348,0.05560654,0.030786889,-0.056948792,0.049619325,0.080593415,0.030653782,-0.028118072,-0.017039584,-0.017147163,0.035602145,0.014092082,0.11933566,-0.12810476,0.04803166,0.07124964,-0.039638605,-0.1121542,0.038059313,-0.023929758,0.0058207596,0.042537685,0.07964378,0.007044588,-0.016522175,0.03769551,0.00549731,0.025653556,-0.013827206,-0.031100051,-0.06760676,-0.043434218,-0.05438122,0.026151922,-0.015909996,0.0563874,-0.065170884,-0.024037035,-0.043791715,-0.028747195,0.027518697,-0.0028830087,0.03464609,0.055856504,0.038217817,-0.010870676,0.060692713,-0.13966045,0.020481149,-0.06901048,0.023897413,-0.025815094,0.024861882,-0.02897667,0.0021216387,0.025950857,0.041904636,-0.045879446,0.04789636,-0.01762838,-0.0064311004,-0.10499671,0.034739938,0.055723768,0.024282942,0.020306738,0.007048485,-0.019659242,-0.050404962,0.02645627,0.010049191,-0.018131845,0.017850831,-0.10890563,-0.06784121,0.020520655,-0.01992795,0.07610492,0.0041709123,0.00792884,-0.02432087,0.07870307,-0.04224385,-0.121847466,-0.04595058,-0.066450216,0.027795004,0.053991523,-0.014276745,0.015918715,0.029676616,-0.02764747,0.0072695864,0.007338339,0.041974157,0.04374268,0.069186226,-0.06883845,-0.079169,-0.008577173,-0.027358726,-0.09354725,-0.015532098,-0.0005887682,-0.07845819,0.04879283,-0.13372257,5.0855926e-33,0.059974942,0.030835146,-0.021473844,-0.058345225,-0.0070178895,0.029692415,-0.06690596,0.015557771,-0.031132549,-0.08591527,-0.0860942,-0.065278016,0.075923,0.04992233,-0.00847862,-0.047783587,-0.03492899,0.03520479,0.03386962,0.0017014521,0.070508644,0.012132526,0.0067943246,0.023970988,0.073114626,0.056596663,0.03134814,0.0034996974,0.024751885,-0.01727847,0.062389024,-0.038482532,-0.124656394,-0.047908306,0.028773975,0.023682034,-0.0863323,0.014529783,-0.05609755,-0.006906975,-0.094457865,0.0793505,-0.041782487,0.05697857,0.076321036,-0.0042571086,-0.072526224,0.04355473,0.07251551,0.030292131,-0.012254443,0.008326292,0.060903918,0.019041494,0.022859717,0.0053576124,0.025078285,0.011253247,-0.018000342,0.07374875,0.03240299,0.07999163,-0.015973086,0.095410384,-0.011674561,0.08528008,0.01245046,-0.07788087,0.011915592,0.10408206,0.013846819,-0.06450336,0.03495538,-0.02093293,-0.01571406,-0.06441894,0.01617508,-0.061944317,0.0006784863,-0.019123191,0.052953638,-0.064131014,0.045511093,-0.012126083,-0.053296488,-0.05201159,-0.0321422,-0.022159334,0.021971377,0.03773095,0.08404052,-0.1200594,0.0040682782,-0.008669773,-0.022329153,-5.075879e-33,0.08393445,-0.056540616,0.07279292,-0.064138964,-0.07881197,0.105217755,0.052176706,0.0040462823,0.07819849,-0.022653444,0.095702685,0.063861825,0.059659652,-0.007077051,0.015191137,-0.024187848,0.006921532,0.06893817,0.08497283,0.015786637,0.036314525,0.10294734,0.044059675,0.005453116,0.022458214,0.026996357,-0.08021054,0.024673771,0.021007648,-0.039054643,-0.07756649,-0.007046079,-0.09430972,-0.0565284,-0.035532713,0.05694476,-0.035575684,0.03552372,-0.0035000863,-0.0072793593,0.017347066,0.02072715,0.0018725285,0.062472697,0.006844841,-0.01771208,-0.12895748,-0.010216247,-0.02576223,-0.049773227,-0.023598913,-0.012628249,-0.008536664,-0.0154267885,0.06452317,0.029871153,-0.03925371,0.05909312,-0.07795994,-0.018832933,-0.03357811,-0.08913237,0.06960126,0.0012603077,0.012964962,0.104018316,0.067349054,0.052348997,-0.003676552,-0.021153042,0.048933513,0.03451723,0.009057173,0.09759622,-0.01725115,0.026666995,-0.10457182,-0.059087396,0.0033335641,-0.018127749,0.04463348,0.039015558,-0.023211118,-0.0065900544,-0.008250121,-0.05113673,0.040007062,-0.0067360965,-0.01620876,0.0025131467,-0.029509103,0.04316849,0.06781163,0.018148279,0.06656416,-4.6567468e-08,0.023189377,-0.02325479,0.095823355,-0.039303884,0.03097385,0.03578326,-0.031622183,-0.07484819,0.042942993,-0.04948472,0.014831706,0.08291843,0.008237586,0.03450097,0.051546782,-0.008402818,-0.07701169,-0.018480428,-0.05262409,0.01427727,-0.053618792,0.016216788,-0.045932837,-0.021366624,0.0058678943,-0.0109768845,0.047306597,-0.005939979,-0.033077825,-0.018508075,-0.06802562,-0.019444192,-0.05985885,-0.0071336315,-0.06484058,-0.01985863,0.0046552536,-0.047590174,-0.11044561,0.041847546,-0.016250772,-0.023039397,-0.083461,0.03748487,0.013176691,-0.0188812,-0.014589349,-0.09153172,-0.07317508,0.053053383,0.0545391,-0.009797743,-0.013767024,-0.049151167,-0.13219668,0.025569603,-0.033309825,-0.033752795,-0.031150242,0.055317283,0.04980117,-0.00466829,0.12438734,-0.0061176294 +1.13.11.95,"The enzyme, characterized from the bacterium Streptomyces sp. NCIMB40513, is a cupin dioxygenase that participates in the biosynthesis of the monoterpene alkaloids altemicidin, SB-203207 and SB-203208. The enzyme catalyses a complex transformation: it first catalyses a monooxygenation of the sulfur atom, which results in decarboxylation and formation of (Z)-(2-aminovinyl)sulfanolate. This is followed by a dioxygenation of the sulfur atom, forming (Z)-2-aminoethene-1-sulfonate. The resulting compound is unstable and undergoes an intramolecular rearrangement in which the amino group moves onto the oxidized sulfur atom, displacing an oxygen atom in the form of a water molecule and forming an SN bond. Another water molecule (not shown in the overall reaction) donates an oxygen atom that replaces the nitrogen at the other end of the molecule.",384,1.0,-0.10349995,-0.06471037,-0.12824656,-0.010360145,0.0076277005,0.051045343,-0.044879977,0.009329994,0.034023527,-0.0033104375,-0.030524116,-0.01291834,-0.009209811,0.04140596,-0.07503256,0.047137905,-0.11752937,-0.0047941655,0.0268122,-0.08144811,0.06736717,0.04667462,-0.034372732,-0.021078138,0.04855882,0.07527113,0.0007103361,-0.010150561,-0.035199117,-0.052176695,0.10517089,0.0031574361,0.02232502,-0.06633798,0.046668667,0.03179081,-0.040724646,-0.015214438,0.046282936,-0.0058902325,0.00058041216,0.0060958266,-0.0299721,0.011842749,-0.02267733,-0.02411222,-0.007399409,0.04226525,-0.03797716,-0.053126,-0.05978288,-0.09910757,-0.071200915,0.07620768,0.066288605,0.004619171,-0.04726611,-0.04726224,-0.008372545,-0.035813406,0.0655736,-0.0006338913,0.005652668,0.0008799724,0.03184969,0.0033746068,0.030827338,-0.09627574,0.075535685,-0.059835657,-0.09112573,-0.06228497,-0.035906274,-0.006134259,-0.037019417,0.04462085,0.040495887,-0.019190157,0.032017767,-0.03072765,0.042424254,0.04773336,0.050124798,0.11937095,0.06822322,0.0043282798,0.029669147,-0.010007455,0.0709607,0.02526964,-0.011785964,-0.00032907052,-0.025513656,-0.038511842,-0.089307405,0.029854938,-0.016520381,0.08169732,0.0032297436,0.05319456,0.009669885,0.08679539,-0.0032679157,-0.12643848,0.014791521,-0.011825918,0.036421698,0.10192109,0.0022722275,0.023334755,-0.013636548,-0.007657687,0.023979029,0.02447065,0.0093757175,0.08116202,0.052897204,0.0105999485,-0.06565062,0.003410346,-0.029945154,0.0011802729,-0.027605206,-0.0070748026,-0.07446321,0.08409303,-0.13695286,2.722405e-33,0.059271667,0.034200728,0.026576698,0.045166522,0.013967608,-0.017081732,-0.0528836,0.057527464,-0.06741251,0.016944151,-0.07259338,-0.051063564,0.058119945,0.015930893,-0.034820817,-0.097237326,-0.0721197,0.035600502,0.038658153,0.0045182933,-0.0038577016,0.052211434,-0.09185904,-0.025223823,0.07104869,0.03754471,0.018517205,0.020824637,0.042045362,-0.0070311856,0.02645115,-0.05083526,-0.12461942,-0.06179709,0.09940263,-0.09359033,0.0043702396,-0.025652096,-0.026072383,0.049238376,-0.032574546,0.033315018,-0.051023614,0.024165288,0.073424324,-0.054582424,-0.04356581,0.11091435,0.058106065,0.026276633,0.019075967,0.009835479,0.08853565,0.03544263,-0.08228299,0.039928626,0.0043794094,-0.018697262,0.05774125,0.030047957,0.042223543,0.0422544,-0.04386161,-0.03244237,0.07768756,0.02646726,-0.04347729,-0.019712906,0.030430289,0.08979089,-0.076372854,0.007672543,0.046971265,0.025544338,0.020314615,-0.015997427,-0.026179006,-0.028989587,0.068193905,0.004018319,-0.016832367,-0.01990144,0.0050262753,-0.04669395,-0.034316402,-0.07517166,-0.0489144,-0.09698221,-0.059298705,0.035147212,-0.0010092589,-0.07797532,-0.034084085,-0.018977646,-0.011297741,-3.8556204e-33,0.06624567,-0.08435229,-0.009024291,-0.08318614,-0.054983728,0.049095664,0.022296397,-0.04915134,0.0133473575,-0.020312874,0.07464885,0.02807064,0.09107082,-0.032334454,-0.0013077727,-0.033244565,0.0059212055,0.037716556,-0.0319341,0.013672283,0.048131563,0.16043149,-0.008671085,0.01975599,0.012298561,0.029538002,0.04354653,0.10092218,0.07964501,0.086894274,0.03558859,-0.025573242,-0.04226074,-0.06034912,-0.09185966,0.07972406,-0.049283613,-0.017129103,0.046487935,-0.012012929,-0.01900207,-0.013387623,0.0049017174,0.11683114,0.08291246,0.023937715,-0.12563318,0.019510852,0.03755693,-0.10028213,0.02389383,-0.0033283338,-0.017688323,0.026126334,0.03934188,0.009302278,-0.012258924,-0.07111194,-0.038159642,-0.004551887,-0.028441602,-0.027346995,0.07750673,-0.017831441,0.014183931,0.013277315,-0.011065083,-0.010458904,0.050829884,-0.07022224,0.043782827,0.001052492,-0.012695391,0.028756212,-0.02171668,-0.040782213,-0.010014812,0.053924624,-0.03302892,-0.015816936,0.013789103,-0.0051523354,0.037017137,-0.0483212,-0.020488843,-0.12800533,0.046236347,0.0717785,0.0168139,0.034195565,-0.046226565,0.03274005,-0.08698709,0.08757678,0.046108607,-5.1332194e-08,0.012326254,-0.029645989,0.09771312,0.051212505,0.0079322625,0.049628995,-0.011643241,-0.09902194,0.012602186,-0.04651843,0.0011770438,0.058248498,-0.0073011303,0.033839654,0.037536234,0.07039486,-0.032772098,-0.014162698,-0.039859064,-0.03833982,-0.06298308,-0.03896152,-0.03825189,0.047350135,0.040162113,-0.1100633,0.0044760886,0.016287416,-0.017590506,-0.0125060165,0.0025282379,0.05280169,0.013815477,0.023129553,-0.030073022,-0.0005048227,-0.060652006,-0.03206073,0.03374964,-0.00045987003,0.007923837,0.024720829,-0.10625456,0.044754393,-0.007937047,0.032674383,-0.030796312,0.023167359,-0.09015503,0.04008293,0.07860313,0.036764614,-0.040881116,0.0006036463,-0.09071731,0.0865132,-0.02105304,-0.06368596,0.011129359,0.008836898,0.01059392,-0.02441326,0.13551046,-0.026500551 +1.14.13.253,"The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The vertebrate enzyme has no activity with 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol (cf. EC 1.14.99.60, 3-demethoxyubiquinol 3-hydroxylase). The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.",384,0.99999994,0.0009502481,0.019084383,0.0018725485,-0.019014971,-0.018257236,-0.0033697665,-0.066975705,0.02975634,0.033087242,-0.07357618,0.053513415,-0.0062798914,-0.05083856,-0.0036037783,-0.04610054,0.04343106,-0.07483486,-0.014369176,-0.023014504,-0.040436275,0.05786872,-0.015178452,-0.008592719,0.02924581,0.019668015,-0.06643366,0.050971262,0.034222428,-0.011016764,-0.022092864,0.030628808,-0.09017555,0.030137965,-0.07626935,-0.017851874,0.060532853,-0.042235818,-0.029052261,0.032825857,0.061126612,0.09514633,-0.08737939,-0.060785085,0.11229123,-0.01668458,0.031718105,-0.09203431,0.06881197,0.086661465,0.040570807,-0.045577906,-0.023719806,0.040570654,0.06634393,0.01523684,0.050666597,-0.041179866,0.058317687,-0.024612095,-0.02770845,0.05787862,0.041460793,0.00844633,-0.0065254862,0.019716794,0.017286845,-0.012131038,-0.046097994,0.039053053,0.012706114,-0.01804582,-0.03882336,-0.08540785,0.0404096,-0.08561092,-0.010259228,-0.054291207,0.0020150235,-0.007747156,-0.05613603,-0.021623371,0.005708591,0.062012445,0.018664382,0.041605614,0.043493174,0.06621604,-0.0012468987,0.0070428387,0.03078677,-0.015872352,-0.06536515,-0.033189535,-0.032048073,-0.017130958,0.038028553,0.060801707,0.08614219,-0.007348759,-0.0354056,0.028285442,-0.011816098,-0.03954622,-0.10979476,-0.0811011,0.024744278,-0.016800439,0.025021765,0.03520505,-0.0012631465,-0.0245321,0.0067570936,0.025273388,0.02754894,0.0024396612,-0.03335234,0.016350878,-0.020585245,-0.043995496,-0.028408483,-0.03464178,0.059482396,0.057398878,0.05929648,-0.020490298,0.0025016954,-0.12723383,-1.5756705e-34,0.033559542,-0.0046423124,0.005573116,-0.022989977,-0.06457346,0.019321347,-0.06655436,0.045148276,-0.1356862,-0.03532456,-0.056087848,-0.010209099,0.018050024,0.042745728,0.072469234,-0.018901179,0.08098394,-0.021278413,0.090108976,-0.049989294,-0.060282364,-0.03567446,-0.03345322,-0.06529987,-0.030705215,0.013222328,-0.06686284,0.01136909,-0.023243617,0.022450857,-0.05487764,-0.099803075,-0.09461906,0.026673889,0.017334707,-0.030163767,-0.06322278,-0.051512636,-0.028134251,0.02852993,0.060209546,0.044416104,0.030556107,-0.038481936,0.05386597,-0.013784991,-0.02924535,0.1404466,0.022425946,0.00023038544,0.034228005,0.0518206,0.09252128,-0.07890447,-0.08916271,0.008911632,0.041553564,0.0007433347,-0.012452038,0.062394105,-0.057674475,0.10585694,-0.0074672806,0.005237857,0.010224632,0.038751967,-0.07581483,0.014868166,-0.01995575,0.050179552,-0.009771164,-0.044578932,0.008452786,0.030759903,0.005333102,-0.057963528,-0.027820067,-0.04072269,0.08421759,0.016121425,-0.06726369,-0.043995377,-0.009634011,-0.06328808,0.0004515543,0.046244975,0.059938803,-0.056652557,-0.017196514,0.064274766,0.05288095,-0.07026776,-0.056526333,0.05072114,0.05564479,-2.627808e-33,0.053000707,-0.09508837,0.05660339,-0.049018398,0.014534375,0.076356836,-0.0029840595,0.051640756,-0.023481885,0.013724623,0.1236703,-0.017925091,-0.019748138,-0.00040134555,0.044505782,0.04395473,0.02015656,0.07215862,0.06981338,-0.07045328,0.029077286,0.043201968,-0.01325686,0.041553795,-0.015269443,0.018874343,0.03527203,0.0038591656,-0.018305944,0.046060365,-0.039970823,0.017712748,-0.044607107,0.016402727,-0.019191258,0.015162305,-0.10107495,0.058007557,0.09750731,0.029834999,-0.03076862,-0.0038003402,-0.005439817,0.010681938,0.023024686,0.07533045,-0.067504026,0.05639488,-0.056579024,-0.05449341,0.08013865,0.032309946,0.021351952,0.021531552,0.0026192968,0.035454378,-0.0062925625,0.0046880175,0.029700805,-0.06597991,-0.016196175,-0.047947627,0.049577873,0.04242213,-0.0056729317,0.07286127,-0.032376375,0.07063911,-0.04433523,-0.08584491,0.07659156,-0.026632905,0.0023242254,0.014279846,-0.09012917,0.033200473,-0.035747968,-0.05637095,-0.0033430355,0.022312284,-0.0052097095,-0.047517005,-0.010083481,-0.07686064,-0.070735745,-0.088328436,0.03587904,0.11724558,-0.035815895,0.110985436,0.012339655,0.06983852,-0.094183944,0.016166186,0.15239696,-4.279577e-08,0.03038916,-0.022947796,0.08533539,-0.059263486,0.010596541,0.01596509,-0.029986147,0.04322799,0.03611122,0.03081869,0.0016814743,0.02980269,-0.007670874,0.08373557,0.019564478,-0.0012343207,0.03572162,0.01552123,-0.005818405,0.017236518,-0.096228845,0.046570294,-0.068915434,-0.06894762,-0.037042346,-0.11684609,0.06626656,0.055321693,-0.04505414,-0.060213327,0.015701089,0.025062833,-0.07555526,-0.03979034,-0.07309213,0.072012685,-0.03989812,-0.07159787,-0.0100422595,0.025405852,-0.033883423,-0.08882199,0.009056777,0.036393598,0.028037606,-0.028865429,0.068457596,0.034114912,-0.033402942,-0.029214278,0.012047142,-0.03951615,0.05681476,-0.12167446,-0.041144706,0.03803932,-0.07369207,-0.059916753,-0.028549138,-0.075476214,0.02789963,-0.009798104,0.18802789,-0.02582195 +1.14.14.188,"A cytochrome P-450 (heme-thiolate) protein. The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine.",384,0.99999994,-0.032920267,0.046522405,-0.122850694,-0.039602757,0.0324586,0.09402134,-0.017022088,0.0800278,0.053710382,-0.0098830005,-0.015216341,0.002001499,-0.07059588,0.020462545,-0.03169046,0.0059504644,-0.06743551,-0.017857123,0.0077381567,-0.12451742,0.030661143,0.115058616,0.022836056,0.015116277,-0.026944384,0.013450248,0.031402472,0.038646705,0.023812143,-0.046256516,-0.007739247,-0.026004348,0.055721276,-0.022498278,0.020271739,0.09571187,-0.07031347,-0.091936424,0.021294743,-0.018483136,0.08241939,0.009832681,-0.1051896,0.09441783,-0.08077587,-0.020549811,0.015488738,0.048987877,-0.011362008,-0.022771504,0.028741712,-0.051256724,-0.0729274,0.045003567,-0.036311436,0.079255715,0.008262532,-0.02541854,-5.6877157e-05,-0.034139592,-0.0070797806,0.07688065,0.0009918949,0.008562248,0.03507808,-0.024268739,0.006253758,0.00925433,0.024515772,-0.085124835,-0.017364725,-0.073011264,-0.035768267,0.028319973,-0.08185874,0.05787889,-0.0056011737,-0.006515202,-0.03848111,0.004336081,0.055523355,0.004622608,-0.013728112,0.10803735,0.06434835,0.012809192,-0.072906435,0.0838981,-0.021254554,-0.023250567,-0.007938708,0.009309685,-0.01876207,-0.021887206,-0.09753417,0.021805748,-0.0037562437,-0.019397324,0.001357199,-0.013232899,0.04272387,0.06193696,0.04194858,-0.047426596,-0.051925447,0.012935223,-0.043368734,0.047282286,0.061072554,-0.042805057,-0.06557584,0.0021622267,0.0068550063,-0.029848015,0.0028077392,0.056561388,-0.0054634367,-0.012177208,0.0058938973,-0.04661838,-0.014439323,0.016168918,-0.01531607,0.030649817,-0.0042829067,0.013323971,-0.1489541,5.420018e-34,0.061063297,0.0650083,0.028972397,0.011804809,-0.0018715694,-0.0021616076,-0.048868883,0.027934466,-0.037337724,0.013282608,-0.09713397,-0.120530434,0.031510465,-0.06574873,0.03064484,-0.020514203,-0.047788803,0.058113363,0.047593955,0.0046217507,-0.063106515,0.04669789,-0.057165343,-0.0018823143,0.025324484,0.09405764,-0.06441632,-0.011116253,0.03893815,-0.011606748,-0.05925825,-0.038116068,-0.042711128,-0.06079838,0.06635589,-0.040314626,-0.022786653,-0.0414891,-0.019316,0.025013046,-0.033049587,-0.02625924,0.03520998,-0.0502335,0.037608277,-0.059674952,-0.1577895,0.010185569,0.013232744,0.0069749956,0.038341586,-0.06507145,0.12644747,0.06982178,-0.0887241,0.004476217,0.009097695,0.006619899,0.020392893,0.063790776,0.08358842,0.029802626,-0.01780924,0.07216653,0.07479749,0.03166373,-0.072331056,-0.054729544,-0.044037946,0.14336082,-0.07593111,0.02355707,0.032792203,-0.104058325,0.04358082,0.00024930036,-0.043250028,0.08795284,0.035770327,0.044498224,0.021048343,-0.055171736,-0.04445597,-0.042379223,0.011637008,-0.026947316,0.08325551,-0.038811825,0.0033202465,0.067338064,0.029628824,-0.089759596,-0.028069176,0.005541454,0.04213858,-1.5279959e-33,0.04766087,-0.08769853,0.03400658,-0.07255001,-0.014264504,0.086005114,-0.016551226,-0.05779902,-0.095499285,-0.021206498,0.07990652,-0.010409792,-0.010254527,-0.024631262,-0.005778518,0.0065799956,-0.0028248033,0.09814696,-0.0013681436,0.05621706,0.0047706277,0.011575249,0.014850807,0.003967616,0.03092493,-0.02629999,0.049942948,0.021982137,0.06499059,0.0024039017,-0.013439351,0.046558995,-0.07100437,-0.06619317,-0.054257832,0.05128025,0.030106781,0.03365695,0.055715747,0.008511439,0.0020579398,0.08538469,0.03004254,0.07141865,0.016561024,0.13624372,-0.070879854,-0.016760005,-0.0601127,-0.035776943,0.0845063,0.01654413,-0.0034468607,0.05827841,-0.012280454,0.008495241,-0.0077778497,-0.0070041646,-0.0115799075,-0.06585643,-0.022030614,-0.020700725,-0.0612113,0.046678882,0.05548691,-0.018538091,-0.04691505,0.06717793,0.06325864,-0.014407695,0.016568929,0.041309655,0.038931284,0.10410535,-0.012671675,-0.0005096469,-0.022686176,-0.023303984,0.06535283,-0.0071158204,-0.027571639,0.0036307385,-0.030580146,-0.053948868,0.006619442,-0.092253625,0.007191916,0.124917835,0.065284066,0.0026074639,-0.04344068,0.07615275,-0.066060856,0.05890195,0.030088177,-3.2510133e-08,-0.03717901,-0.062064577,-0.031816915,-0.050954647,0.00978838,0.015240092,0.04985161,-0.00896499,0.052854266,-0.006970839,-0.006058479,-0.018171264,0.008958048,-0.047096655,0.009514996,0.047075134,-0.026806736,0.026748983,0.071173616,0.034908682,-0.016818797,0.0526459,-0.033479776,0.057412818,0.031348106,-0.09128809,0.009800271,0.02622304,0.030893762,0.01487856,0.020753387,0.0443862,-0.021092167,-0.024160463,0.010582051,0.031964846,-0.021483589,-0.045185957,0.00073031127,-0.013093152,-0.0054766964,-0.040527776,-0.10062993,-0.01773939,-0.04154007,-0.0012398898,0.06465544,0.049350206,-0.015993245,-0.05255092,-0.033806,0.032613963,-0.008084827,-0.10195213,-0.10618735,-0.023020163,0.04792576,-0.0789347,-0.037715983,-0.12174077,0.035074353,-0.0217933,0.1902679,-0.031644743 +1.14.14.189,"A cytochrome P-450 (heme-thiolate) protein. The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine.",384,1.0,-0.055366278,0.035858374,-0.11555277,-0.061936177,0.045266937,0.08490132,-0.029607855,0.0735381,0.034330867,-0.012151281,-0.015924966,-0.05424261,-0.071802914,-0.009276458,-0.028546846,0.0091091,-0.07362308,-0.013049793,0.012970627,-0.13328749,0.0087356195,0.09101308,-0.010536434,0.059563328,-0.021699354,0.03739168,0.06837336,0.019025335,-0.0027443839,-0.07204501,-0.035608992,-0.035587747,0.08319708,-0.022822306,0.03812139,0.1111396,-0.060182825,-0.066245764,0.026810862,-0.02452578,0.039007958,0.008855944,-0.061227083,0.050913952,-0.033013582,-0.0021395632,0.006496403,0.06346286,-0.025196493,0.021711666,0.058499,-0.04679922,-0.058389377,0.060175497,-0.022673216,0.0730516,-0.009308842,-0.033972938,0.013343149,-0.028404921,-0.013653861,0.077167295,-0.011217525,-0.011379347,0.009964517,-0.03547321,-0.02158131,-0.010876207,-0.008080121,-0.08947976,-0.00093819154,-0.097951055,-0.077276796,0.044775315,-0.048328917,0.03774759,-0.025861565,-0.014854962,-0.0316468,0.014429405,0.029805092,0.0063492255,0.0013397104,0.098480746,0.066109054,-0.032432552,-0.036958836,0.03169015,-0.025333317,-0.025962029,0.010415711,-0.0016843698,-0.031585936,-0.0034129713,-0.08895968,0.049460996,0.019283224,0.008034043,0.021210143,-0.033612024,0.03658182,0.055449296,0.019636977,-0.082343616,-0.094187304,0.0106242,-0.019203926,0.086109035,0.093911186,-0.055764545,-0.06317554,-0.0047123902,0.0062205754,-0.004966423,0.02718495,0.0923213,0.021061035,-0.02592465,-0.010163612,-0.024405498,-0.011988682,0.02775551,0.026714426,0.030825121,-0.017745046,0.02506882,-0.124366656,3.055615e-35,0.088320434,0.018894872,0.00041070653,0.031335473,-0.03590361,-0.019480396,-0.07069749,0.035725057,-0.06338795,-0.011987902,-0.09581783,-0.090633534,0.051908344,-0.086800866,0.012019109,0.008468396,-0.06543214,0.032303512,0.032233957,0.025667103,-0.045212664,0.05562366,-0.028766237,0.018917967,0.02742741,0.08834556,-0.018923583,-0.025897522,0.058613647,-0.000599323,-0.0399741,-0.05751948,-0.0107967025,-0.054490574,0.057358343,-0.01657155,-0.010117845,-0.020715017,-0.07921537,0.04786271,-0.019738812,-0.0340642,0.0068065147,-0.08977482,0.052312333,-0.06707071,-0.124261245,0.011346347,0.00095660763,0.007903042,0.05481233,-0.037073296,0.11491763,0.06615606,-0.060927738,0.03831393,0.0091828015,0.023995152,0.033083715,0.064934425,0.10610249,0.070885204,-0.007972172,0.056970533,0.05460601,0.003160827,-0.064813316,-0.03615025,-0.053075697,0.110206924,-0.07806128,-0.041051723,0.017682852,-0.08812894,0.052245237,-0.03716274,-0.03109126,0.07900063,0.025857558,0.05369779,0.03684651,-0.012987154,0.0014028879,-0.03549392,0.014059151,-0.028518781,0.062038843,-0.03113906,-0.012182582,0.056913514,0.034882832,-0.05863972,0.0020321591,-0.007211283,0.04126668,-1.0444466e-33,0.054608215,-0.11196185,0.015026352,-0.057642255,-0.04134697,0.078174576,-0.012327198,-0.08375955,-0.029998846,-0.0031191471,0.095755644,-0.0147763025,-0.033924937,-0.031174498,0.033626594,-0.031935122,0.01806735,0.06432051,-0.011704247,0.064802356,0.0065066684,0.013643748,0.014871885,-0.035963222,0.008993292,0.003907512,0.012399347,0.05436364,0.10578372,-0.012771357,-0.06368502,0.048800845,-0.025284525,-0.056143623,-0.05589596,0.053561725,0.005887198,0.014764663,0.031337276,0.0062132156,-0.040101066,0.061254214,0.005935009,0.060224805,0.04984116,0.091649815,-0.055950273,-0.02296072,-0.066619,0.0013038797,0.09449445,-0.0021844017,-0.008046754,0.046244737,-0.0028779088,-0.02385715,-0.054307867,0.03392705,0.041220512,-0.043684017,-0.034403633,-0.022254592,-0.04385298,0.038846344,0.049812105,0.02330393,-0.09885918,0.05883907,0.056871396,-0.00028215666,0.021636307,0.035961274,0.050098028,0.102744505,0.02191191,-0.025970658,-0.011953895,-0.0015971917,0.044402704,-0.019590437,-0.066478714,0.0123736,-0.017594408,-0.08606018,0.016545799,-0.12147548,-0.0324446,0.11891848,0.060437884,-0.008134852,-0.047798183,0.04204736,-0.039003268,0.053454466,0.015346592,-3.1669146e-08,-0.050898902,-0.082651965,-0.03775071,-0.028160717,0.02530774,0.014303646,0.072780535,-0.01880226,0.040810928,-0.033464827,0.019616822,0.025915856,0.021452297,-0.055252243,0.028303994,0.06629967,-0.010963303,0.0059759333,0.061427783,0.049252607,-0.00215891,0.048541535,-0.05364414,0.056523867,0.030157842,-0.08869533,0.033802617,0.024925368,0.007948052,-0.0027992674,0.035538554,0.048753362,0.0099613685,-0.026400162,0.042760026,0.029789561,-0.039338842,0.009723062,-0.0075094206,-0.0134019395,-0.021465363,-0.019833328,-0.11390754,-0.039846726,-0.043024078,0.000827105,0.051068768,0.06562058,-0.01386566,-0.025502658,-0.05151784,-0.020611247,0.03483143,-0.09541272,-0.09099116,0.009486171,0.106910326,-0.14530602,-0.014664534,-0.12512675,0.011125109,-0.024119223,0.19355558,-0.000569878 +1.14.14.190,"A cytochrome P-450 (heme-thiolate) protein. The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine.",384,1.0,-0.055366278,0.035858374,-0.11555277,-0.061936177,0.045266937,0.08490132,-0.029607855,0.0735381,0.034330867,-0.012151281,-0.015924966,-0.05424261,-0.071802914,-0.009276458,-0.028546846,0.0091091,-0.07362308,-0.013049793,0.012970627,-0.13328749,0.0087356195,0.09101308,-0.010536434,0.059563328,-0.021699354,0.03739168,0.06837336,0.019025335,-0.0027443839,-0.07204501,-0.035608992,-0.035587747,0.08319708,-0.022822306,0.03812139,0.1111396,-0.060182825,-0.066245764,0.026810862,-0.02452578,0.039007958,0.008855944,-0.061227083,0.050913952,-0.033013582,-0.0021395632,0.006496403,0.06346286,-0.025196493,0.021711666,0.058499,-0.04679922,-0.058389377,0.060175497,-0.022673216,0.0730516,-0.009308842,-0.033972938,0.013343149,-0.028404921,-0.013653861,0.077167295,-0.011217525,-0.011379347,0.009964517,-0.03547321,-0.02158131,-0.010876207,-0.008080121,-0.08947976,-0.00093819154,-0.097951055,-0.077276796,0.044775315,-0.048328917,0.03774759,-0.025861565,-0.014854962,-0.0316468,0.014429405,0.029805092,0.0063492255,0.0013397104,0.098480746,0.066109054,-0.032432552,-0.036958836,0.03169015,-0.025333317,-0.025962029,0.010415711,-0.0016843698,-0.031585936,-0.0034129713,-0.08895968,0.049460996,0.019283224,0.008034043,0.021210143,-0.033612024,0.03658182,0.055449296,0.019636977,-0.082343616,-0.094187304,0.0106242,-0.019203926,0.086109035,0.093911186,-0.055764545,-0.06317554,-0.0047123902,0.0062205754,-0.004966423,0.02718495,0.0923213,0.021061035,-0.02592465,-0.010163612,-0.024405498,-0.011988682,0.02775551,0.026714426,0.030825121,-0.017745046,0.02506882,-0.124366656,3.055615e-35,0.088320434,0.018894872,0.00041070653,0.031335473,-0.03590361,-0.019480396,-0.07069749,0.035725057,-0.06338795,-0.011987902,-0.09581783,-0.090633534,0.051908344,-0.086800866,0.012019109,0.008468396,-0.06543214,0.032303512,0.032233957,0.025667103,-0.045212664,0.05562366,-0.028766237,0.018917967,0.02742741,0.08834556,-0.018923583,-0.025897522,0.058613647,-0.000599323,-0.0399741,-0.05751948,-0.0107967025,-0.054490574,0.057358343,-0.01657155,-0.010117845,-0.020715017,-0.07921537,0.04786271,-0.019738812,-0.0340642,0.0068065147,-0.08977482,0.052312333,-0.06707071,-0.124261245,0.011346347,0.00095660763,0.007903042,0.05481233,-0.037073296,0.11491763,0.06615606,-0.060927738,0.03831393,0.0091828015,0.023995152,0.033083715,0.064934425,0.10610249,0.070885204,-0.007972172,0.056970533,0.05460601,0.003160827,-0.064813316,-0.03615025,-0.053075697,0.110206924,-0.07806128,-0.041051723,0.017682852,-0.08812894,0.052245237,-0.03716274,-0.03109126,0.07900063,0.025857558,0.05369779,0.03684651,-0.012987154,0.0014028879,-0.03549392,0.014059151,-0.028518781,0.062038843,-0.03113906,-0.012182582,0.056913514,0.034882832,-0.05863972,0.0020321591,-0.007211283,0.04126668,-1.0444466e-33,0.054608215,-0.11196185,0.015026352,-0.057642255,-0.04134697,0.078174576,-0.012327198,-0.08375955,-0.029998846,-0.0031191471,0.095755644,-0.0147763025,-0.033924937,-0.031174498,0.033626594,-0.031935122,0.01806735,0.06432051,-0.011704247,0.064802356,0.0065066684,0.013643748,0.014871885,-0.035963222,0.008993292,0.003907512,0.012399347,0.05436364,0.10578372,-0.012771357,-0.06368502,0.048800845,-0.025284525,-0.056143623,-0.05589596,0.053561725,0.005887198,0.014764663,0.031337276,0.0062132156,-0.040101066,0.061254214,0.005935009,0.060224805,0.04984116,0.091649815,-0.055950273,-0.02296072,-0.066619,0.0013038797,0.09449445,-0.0021844017,-0.008046754,0.046244737,-0.0028779088,-0.02385715,-0.054307867,0.03392705,0.041220512,-0.043684017,-0.034403633,-0.022254592,-0.04385298,0.038846344,0.049812105,0.02330393,-0.09885918,0.05883907,0.056871396,-0.00028215666,0.021636307,0.035961274,0.050098028,0.102744505,0.02191191,-0.025970658,-0.011953895,-0.0015971917,0.044402704,-0.019590437,-0.066478714,0.0123736,-0.017594408,-0.08606018,0.016545799,-0.12147548,-0.0324446,0.11891848,0.060437884,-0.008134852,-0.047798183,0.04204736,-0.039003268,0.053454466,0.015346592,-3.1669146e-08,-0.050898902,-0.082651965,-0.03775071,-0.028160717,0.02530774,0.014303646,0.072780535,-0.01880226,0.040810928,-0.033464827,0.019616822,0.025915856,0.021452297,-0.055252243,0.028303994,0.06629967,-0.010963303,0.0059759333,0.061427783,0.049252607,-0.00215891,0.048541535,-0.05364414,0.056523867,0.030157842,-0.08869533,0.033802617,0.024925368,0.007948052,-0.0027992674,0.035538554,0.048753362,0.0099613685,-0.026400162,0.042760026,0.029789561,-0.039338842,0.009723062,-0.0075094206,-0.0134019395,-0.021465363,-0.019833328,-0.11390754,-0.039846726,-0.043024078,0.000827105,0.051068768,0.06562058,-0.01386566,-0.025502658,-0.05151784,-0.020611247,0.03483143,-0.09541272,-0.09099116,0.009486171,0.106910326,-0.14530602,-0.014664534,-0.12512675,0.011125109,-0.024119223,0.19355558,-0.000569878 +1.14.15.41,"A cytochrome P-450 (heme-thiolate) enzyme characterized from the bacterium Streptomyces turgidiscabies. The enzyme participates in biosynthesis of thaxtomins, cyclic dipeptides formed from the condensation of 4-nitro-L-tryptophan and L-phenylalanine that have phytotoxic properties. The enzyme requires ferredoxin as its electron donor and catalyses a reaction in which nitric oxide is oxidized to a nitro group and inserted into L-tryptophan at the 4 position (not necessarily in this order).",384,1.0,-0.05467218,-0.020151263,-0.09665479,0.023402723,0.03556133,0.03973602,-0.019771354,0.07865263,0.01922477,-0.04155066,-0.028035646,-0.025812365,-0.011179097,0.03857089,-0.07035036,0.008082126,-0.073365584,-0.018161656,0.03009419,-0.058196343,0.0023893446,0.051301323,0.007570519,-0.016273947,-0.018970383,-0.016412014,0.020984573,-0.0025259096,-0.038844187,-0.044911142,-0.0034459664,0.0342223,0.05378441,-0.048211362,0.048657447,0.1302001,-0.052697767,-0.040937267,0.04253467,-0.045820825,0.012054756,-0.04394448,-0.04654631,0.059537996,-0.07302535,-0.028321866,0.0655586,0.06685805,-0.015264907,-0.04378891,-0.07774787,-0.07270099,-0.059899405,0.06318393,0.017017383,-0.0047150725,-0.019477427,-0.09927927,0.022379944,-0.058623236,0.045630965,0.057083208,-0.008932647,0.01329594,0.013858701,-0.021477444,0.030430755,-0.06191681,-0.016153103,-0.04278032,-0.047576513,-0.05948718,-0.028415293,0.012373501,-0.06720831,0.033198934,0.008483547,-0.008187852,-0.0053765834,-0.00065412396,0.04631809,0.00743639,0.00074396457,0.1181113,0.077891365,-0.023978509,-0.04138028,0.05007295,0.008148889,0.008705281,0.017880134,0.04752905,-0.0040804185,-0.046883173,-0.09545337,-0.0017397687,-0.04752854,-0.026407847,0.018781628,0.011781539,0.037920147,0.049384244,-0.0019864952,-0.062230192,-0.017021345,-0.031468697,-0.032170236,0.051821955,0.10769653,-0.045130964,-0.038943443,-0.036032733,0.029792987,-0.027854575,-0.016295869,0.047757376,0.012918777,-0.04324488,-0.050244145,-0.01067696,0.02197079,0.032313302,0.029414905,0.0022864852,-0.027036672,0.010669439,-0.13770796,5.816446e-33,0.09556577,0.01235875,0.0057403627,0.0052949316,0.043492332,-0.0061241207,-0.097001396,0.004234065,0.0055121263,0.023567062,-0.09277527,-0.12533922,0.021913214,-0.02939458,0.014735043,0.005588368,-0.11147977,0.0422484,0.037168175,0.058582827,-0.03654699,-0.0027005044,-0.051224165,0.017766157,0.02362369,0.13240685,-0.037244588,0.01461881,0.057865135,-0.012192044,0.04360871,-0.09567173,-0.09778834,-0.047905277,0.066290945,-0.03696295,-0.021807162,-0.0069899336,-0.03939199,0.058083974,-0.115303114,0.008158099,0.03218555,-0.049144946,0.11417925,-0.036141206,-0.067764565,0.08227816,0.051810876,0.05010468,0.023323666,-0.06946085,0.105052516,-0.013419003,-0.04751058,0.027506217,0.03412027,0.08058127,0.05023879,0.026628615,0.06774604,0.028891958,-0.020535732,-0.008541941,0.039248157,0.0635348,-0.0016762951,-0.034261625,0.0051916325,0.10650574,-0.07785883,0.02828946,0.060353052,-0.024560558,0.020794248,-0.056242824,-0.05018999,-0.0019078668,0.08738473,0.028091406,0.05757071,-0.03351554,-0.027443381,-0.08739744,-0.014595656,-0.018381257,-0.016472321,-0.024276432,-0.0036049588,0.049275458,-0.011505282,-0.10909534,-0.038723838,-0.015809037,0.0010833866,-5.478943e-33,0.07799876,-0.11790542,0.0138917,-0.05172154,-0.03812907,0.043025672,-0.03838624,0.005673643,-0.04907011,-0.02597743,0.118668,-0.012222702,0.029243274,0.008159795,0.02672514,-0.015249656,0.014904856,0.04608098,0.016922051,0.0067786146,-0.014617797,0.03458375,-0.010566762,-0.032536406,0.04374436,0.06954323,-0.030267527,0.029333701,0.13075846,0.010426483,-0.030864699,-0.010643207,-0.084307596,-0.08439647,-0.02731053,0.097163126,-0.014533547,0.028824268,0.04213844,0.040430915,0.06370229,0.056452222,0.06839301,0.10184823,0.01656669,0.09010448,-0.12662293,-0.029619105,0.015655307,-0.04511426,0.05488821,0.027940158,-0.07868612,0.027280886,0.022108933,0.007381886,0.017758459,-0.004180827,-0.008675954,-0.0442234,-0.092110395,-0.10424371,0.01368947,0.07245826,0.0048077046,0.048196666,-0.061087195,0.1075904,0.06436259,0.006049775,0.051082246,-0.016443513,0.038279727,0.0328641,-0.048717577,0.011374127,0.017434087,0.018947719,0.061128765,0.017826665,0.029630572,-0.0335053,-0.045041382,-0.016757043,-0.0002528211,-0.121758364,0.0025168457,0.097212926,0.045993295,-0.032905426,-0.03691039,0.018516703,0.017918676,0.04480136,0.027773973,-4.5434938e-08,-0.009388537,-0.10950635,0.035229195,-0.021271659,0.089992814,0.0020433324,0.010696221,-0.042191334,0.019756952,-0.02261985,0.042777542,0.08602666,-0.031555865,-0.031878013,0.042910643,0.03829531,-0.03444204,-0.0018882806,0.035803866,0.013539161,-0.0612336,0.028126417,-0.082480654,0.054022104,0.048538048,-0.06112599,0.03386293,-0.022659501,0.018947152,0.0007574622,-0.029196579,0.06571372,-0.02898334,0.0043084193,-0.055657722,-0.00951839,-0.10006682,-0.029342655,-0.011169306,-0.03219095,-0.019608976,-0.0062749456,-0.11660558,-0.012929294,-0.021350732,-0.00019618121,0.033251416,0.0032422224,-0.055696927,-0.021206258,-0.031586412,0.0020882315,0.027225725,-0.013601854,-0.093414426,0.05943037,0.10600689,-0.04346701,-0.0524423,-0.059540097,0.034137156,0.055062752,0.1754707,-0.00573739 +1.14.15.42,"A cytochrome P-450 (heme-thiolate) enzyme characterized from the bacterium Streptomyces atratus. The enzyme participates in biosynthesis of rufomycins, circular heptapeptides with anti-mycobacterial activity. The enzyme requires ferredoxin as its electron donor and catalyses a reaction in which nitric oxide is oxidized to a nitro group and inserted into L-tyrosine at the 3 position (not necessarily in this order).",384,1.0,-0.07819161,0.007603644,-0.13246915,-0.00447149,0.019817136,0.04133652,-0.010656664,0.1089443,0.0063461144,-0.031209301,-0.044906802,-0.04235855,0.038936295,0.05260881,-0.050090794,0.0071902145,-0.026316999,-0.013053535,0.06590503,-0.050103664,0.018584514,0.079099886,0.042077128,0.00289289,0.017305814,0.0043982374,0.028999178,0.04576986,-0.06342416,-0.048308913,-0.0044595264,-0.0056312038,0.09557978,-0.037905697,0.055317048,0.1178002,-0.061627332,-0.011608648,0.07623791,-0.018931277,0.005311389,-0.026223304,-0.052632708,0.052659325,-0.043845985,-0.025427207,0.013184925,0.0377235,-0.018628094,-0.060080044,-0.04816691,-0.050741196,-0.059178244,0.03692551,0.03066576,0.01386052,0.011232385,-0.11377767,-0.02358534,-0.061225582,0.071085654,0.021093724,-0.0048247343,0.027505782,-0.03796584,-0.02835083,0.016229974,-0.06421702,-0.006000687,-0.059814397,-0.07060215,-0.07228915,-0.03692472,0.050030287,-0.06535702,-0.006007424,-0.009604087,0.016556652,-0.0110839205,-0.018018624,0.014871063,-0.03239327,-0.0002553683,0.10453089,0.0744093,-0.00062778644,0.006287333,0.019675959,-0.015054721,0.020604497,0.006863066,0.011584391,-0.020369409,-0.041686717,-0.1148218,-0.026863186,-0.02226209,-0.01780586,0.03557118,0.010771498,0.046466053,0.05855143,-0.014246974,-0.045605797,-0.03706075,-0.014376282,-0.043224625,0.056369506,0.09391566,-0.061623897,-0.045742612,-0.04588948,-0.0057442533,-0.03629571,-0.011497244,0.08355249,0.07285857,-0.031935524,-0.053380314,0.012278676,-0.0012546821,0.022008676,-0.012916997,0.015931502,-0.054384336,0.004040033,-0.103307806,4.196711e-33,0.06316555,0.041664913,-0.019493157,0.004310175,0.008052956,0.02294812,-0.10476175,-0.006342063,0.001261052,-0.01469688,-0.09760739,-0.058291566,0.007174238,0.008285792,-0.022215487,0.012073975,-0.07046011,0.038416352,0.054622773,0.015914423,-0.015255379,-0.024226552,-0.043251988,-0.0013116634,0.05919082,0.14111648,-0.033895753,-0.015903031,0.031757835,-0.0051900814,0.036256846,-0.06803618,-0.08334696,-0.04458593,0.038557846,-0.05873073,-0.022134697,-0.020834794,-0.0007110882,0.043165196,-0.10243567,-0.012504959,0.018195596,-0.060447037,0.099728875,-0.035161164,-0.07436839,0.09785226,0.032154746,0.0801324,0.060266327,-0.08723039,0.09516547,0.0017814917,-0.073133126,0.04392177,0.026498556,0.07714756,0.01794822,0.069475725,0.13178726,0.054548945,-0.039364647,0.031240882,0.042242967,0.046346497,-0.008370626,-0.021670053,0.00279329,0.11548966,-0.08907497,0.03492969,0.08836712,0.0037795757,0.021053653,-0.009690056,-0.06393221,-0.00097306015,0.07755698,0.020409467,0.0068391245,-0.011377688,-0.030104427,-0.0935822,0.013809682,-0.0030337304,-0.010166757,-0.06334971,-0.01856292,0.03342905,0.008290303,-0.09557593,-0.037211657,0.018741008,-0.018387688,-4.8392803e-33,0.07774433,-0.09461727,0.023644142,-0.06459564,-0.014918174,0.053272374,-0.0074389623,-0.0029063176,-0.02886139,-0.004633455,0.06990453,-0.028819183,0.013604473,-0.019936292,0.006873372,-0.02986323,-0.0031187506,0.05407663,-0.02535308,0.040676262,0.017286869,0.033974178,0.011550901,-0.028919581,0.02257485,0.039033595,-0.0059003937,-0.0032103753,0.097827055,0.042848047,-0.02243175,-0.005906778,-0.07128593,-0.11719113,-0.036807142,0.098265775,-0.026969014,0.041498646,0.054339834,-0.02839511,0.032813746,0.067729466,0.018138126,0.065722875,0.026152723,0.084365666,-0.13098575,0.006321921,0.014586394,-0.0569703,-0.0008281038,0.025342306,0.008610628,0.007925445,-0.017996844,-0.015865197,0.0040505263,-0.021823432,-0.025564838,-0.02246808,-0.06839247,-0.04738295,0.0052537494,0.086625,0.011961965,0.049692944,-0.046857357,0.06909064,0.07391878,0.0056758453,0.031433348,-0.044563238,0.00036221003,0.057066187,-0.03422174,0.0040456676,0.017782455,-0.016838985,0.05963755,0.046982303,0.022848006,0.0070288824,-0.03377023,-0.05062315,-0.033871487,-0.13259073,-0.020954577,0.08146499,0.07359132,-0.047753762,0.0021155097,0.109303206,-0.02322866,-0.000118159616,0.027035214,-4.1641552e-08,0.043147173,-0.08397697,0.089484096,-0.014151955,0.09510089,-0.024863059,-0.0102288015,-0.06589698,0.047045253,-0.03214413,0.015693821,0.07833246,-0.018070914,-0.08053359,0.028826838,0.063689165,-0.015605982,0.012301039,0.042780876,0.014577005,-0.059037752,0.021813687,-0.08915174,0.026021369,0.088335566,-0.097034134,-0.013449275,-0.017855497,0.041437183,0.031212946,0.03071624,0.046337478,-0.0366869,0.016242454,-0.066157416,-0.018898949,-0.07725073,-0.044510685,-0.0101932045,-0.027077705,0.022794118,-0.026994016,-0.07910799,-0.025032258,-0.047425844,0.044644687,0.003260966,-0.027305666,-0.03971484,-0.010432415,-0.009219588,0.0031189187,0.025531033,-0.03196659,-0.13241564,0.087941445,0.086929694,-0.060720835,-0.04279929,-0.08898062,0.024413075,0.021391317,0.19272907,-0.0044723465 +1.14.15.43,"This cytochrome P-450 (heme-thiolate) enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A.",384,1.0,-0.069124125,0.06272558,-0.10159825,-0.02735704,-0.030638548,0.0063642976,-0.06291146,0.081766665,0.027674176,-0.049513154,0.009290513,-0.060732003,-0.010363448,0.09003492,-0.04178982,-0.0013445233,-0.016612291,-0.0717383,0.011882344,-0.011130529,0.005077439,0.107475065,0.047417182,0.03686198,-0.05802183,0.047863916,0.03876926,0.012191291,-0.016571706,-0.06363417,0.029968487,0.03356182,0.14900534,0.00416222,0.04913795,0.069177195,-0.06002717,-0.018533412,0.053681508,0.010475794,0.037452247,-0.011900183,-0.061597582,0.060370672,-0.011126138,-0.005368669,0.0030209222,0.026508514,0.022708258,0.0029129034,-0.024164142,-0.032346617,-0.052275907,-0.0008026236,0.02583101,0.009185421,-0.023743842,-0.104719914,-0.016258946,-0.07822131,0.017507438,0.06358969,-0.009157706,0.073728375,-0.04418336,-0.021520905,0.027051684,-0.06269582,0.0037767128,-0.06194885,-0.044695392,-0.08142663,0.03416464,0.009518732,-0.089122094,0.015674809,-0.015692035,-0.007863675,-0.00677041,-0.018650057,0.03881893,-0.021274546,-0.049265776,0.09601315,0.019239299,-0.025634555,0.021143826,0.076524615,0.010158104,-0.044639725,-0.0044458127,0.040153846,0.009702233,-0.04378468,-0.11016684,-0.007428823,-0.05482704,0.041606706,-0.007894865,-0.04051211,0.059231665,0.05023959,-0.037171163,-0.051894527,-0.05209256,-0.027726024,0.053343404,0.04721514,0.12191603,-0.02529067,-0.009940116,-0.034176145,-0.026538163,-0.038284242,-0.024210159,0.07197534,0.016734432,-0.036928594,-0.048030525,0.09245654,-0.016556196,-0.07494154,0.0019997635,-0.010097659,-0.06894949,0.07036569,-0.08734429,1.8298223e-33,0.060901903,0.028548624,0.016228396,-0.04513292,0.06940324,-0.027545903,-0.043503635,-0.0042842883,-0.0559088,-0.030246897,-0.08381213,-0.06193121,-0.019866915,0.03153561,-0.042579416,0.0015609021,-0.050825834,0.030561643,0.031876445,0.06612063,-0.019121857,0.024582207,-0.024461681,-0.00587491,0.036384214,0.13000631,-0.012967465,0.018710144,0.06343497,-0.025706995,-0.021287983,-0.085018724,-0.020547096,-0.04186843,0.050566304,0.0119808605,-0.02139118,0.041659784,-0.021464616,0.071133964,-0.0528312,-0.027563652,0.030078968,-0.103251286,0.09696178,-0.03149808,-0.11015891,0.09850148,-0.0035161222,0.068797156,0.091836944,-0.07340599,0.061539654,0.008535457,-0.024751427,0.016696593,-0.009118991,0.11704113,-0.009029845,-0.018958457,0.077581786,0.016657509,-0.06489597,0.01654943,0.030753165,0.013187983,-0.04057457,-0.051253002,-0.02815633,0.0957348,-0.045288946,0.033559863,-0.00651724,0.035605382,0.025155524,0.03602071,-0.030415986,0.089206405,0.07894603,0.004406299,-0.013580899,0.046707895,0.028322693,-0.062067647,-0.006215813,-0.017210137,0.042639315,0.026756205,-0.046398617,0.035460904,0.03942878,-0.08687497,-0.02714203,0.019138945,0.011029938,-2.8264025e-33,0.06719844,-0.076869495,0.04443987,-0.08870481,-0.051536098,0.0901656,-0.00769228,0.02921924,-0.00055634556,0.027435485,0.11383336,-0.010640848,0.008194007,-0.023731586,0.010957117,-0.009225516,0.045510914,0.038421795,-0.05581989,0.03534855,0.028328449,0.014482245,-0.024059225,-0.031203784,0.02383921,0.08462088,0.0073861303,0.04734837,0.048313353,0.012224544,-0.045493152,0.0322172,-0.08581689,-0.08750907,-0.025106225,0.0799771,-0.005655987,0.08408463,0.027992899,-0.041929174,-0.07184149,0.06518726,0.07765118,0.08948857,-0.021959657,0.057889413,-0.057784166,-0.06637686,-0.02163356,-0.05101038,-0.022174822,-0.00055956916,0.002340687,0.062491048,-0.038475413,0.021770839,-0.02435456,0.026212452,-0.00033658766,-0.123411514,-0.056958064,-0.09133115,0.031139765,0.016100897,0.006705335,0.08999847,-0.052237775,0.02064324,0.0747391,-0.07016123,0.0056150197,0.03464876,-0.04996738,0.036800984,-0.06601973,0.0253608,-0.0045946394,-0.06498752,0.047354855,0.010773768,-0.0040390766,-0.02817514,-0.09094779,-0.048965886,-0.020705957,-0.09437903,0.070958994,0.01933692,0.04123105,-0.032943018,-0.019986812,0.08503552,-0.06937126,0.030203644,0.0077339523,-3.0115594e-08,-0.028595885,-0.14666227,0.025073122,-0.026797019,0.027691515,0.007936279,-0.007429581,-0.06552243,0.07113021,-0.06899328,0.055135246,0.07272384,-0.0438447,-0.020809257,0.02367272,0.007328044,0.0074672075,-0.01643684,0.042212795,0.0006932975,-0.040002834,0.015539626,-0.03320263,0.033115823,0.047909748,-0.09041072,0.033086173,-0.06022213,0.03338785,-0.010262112,-0.025402537,0.06828263,-0.008095739,0.0066670165,-0.017022012,-0.04179548,-0.009030266,-0.022867823,0.0015423712,-0.007019886,0.037949245,-0.023275109,-0.10015443,-0.030340012,-0.0066277394,-0.057393335,0.046883427,0.03262764,-0.031988673,-0.04589952,0.0059256554,0.007919024,-0.0098866625,-0.045185506,-0.13629675,0.006944129,0.0796921,-0.034975935,-0.0432447,-0.046950787,0.033738736,-0.014279794,0.20995864,0.0095146 +1.14.15.44,"This cytochrome P-450 (heme-thiolate) monooxygenase catalyses the second of three sequential hydroxylation reactions that occur during the biosynthesis of 20-hydroxyecdysone, the major molting hormone of arthropods. The enzyme also acts on 3-dehydro-2,22,25-deoxyecdysone and 2,22-dideoxyecdysone.",384,0.99999994,-0.09252253,0.026333386,-0.025866086,-0.055051386,0.036744308,-0.0013091295,-0.04550501,0.01946911,-0.031108424,-0.0020215504,0.0072003054,-0.04078091,-0.04396156,0.029266518,-0.0038327705,0.100696534,-0.09522802,0.0040610516,0.0053309724,-0.10840743,0.08378514,0.008539449,0.004401874,-0.03751653,-0.019842,-0.008116222,0.018121973,0.052659485,-0.04386756,-0.019742366,-0.011277117,-0.012676672,0.007878419,-0.022774853,0.011983746,0.08876974,-0.085981846,-0.04908479,0.05977319,0.04724495,0.035063818,-0.042763222,-0.11501328,-0.05081211,-0.06451607,-0.04487497,-0.012017757,0.04842317,0.01532836,-0.014733848,-0.013766916,-0.055900525,-0.058353104,0.034482636,0.02733044,-0.063813865,0.019404858,-0.015948197,-0.023020878,-0.03002343,-0.0645226,0.06245331,-0.07314106,0.052976966,0.014815807,-0.044659354,-0.016606063,-0.06366483,-0.04984028,-0.08330263,-0.026722135,-0.10728735,-0.021134276,0.016403228,-0.09168348,0.009572819,-0.020287935,-0.04917695,0.0273256,-0.049378272,0.007903426,-0.013354419,0.00027104354,0.08782191,0.033113148,-0.026438428,-0.0704523,0.026850196,-0.016921597,0.021636972,-0.017237784,-0.069859,-0.016806219,0.018925287,-0.041460786,0.10063103,0.056697834,-0.014776912,0.0051841936,-0.01968614,-0.021530027,0.045487955,-0.03569669,-0.053596824,-0.019442966,-0.034941535,0.05224229,0.112253636,0.010761492,-0.012084983,-0.068868175,-0.030771954,0.071522295,0.024856964,-0.04628104,0.13814521,-0.043534514,0.009746032,0.024421273,-0.054628443,0.014484891,-0.019169455,0.017290859,0.04783535,-0.02748899,0.07260941,-0.057390906,3.7683447e-33,0.11930252,0.0041547953,0.002917687,0.0028244446,0.016848126,0.041771863,-0.039853327,0.054040838,-0.00047680864,-0.027898831,-0.06661202,-0.08778464,0.021750065,0.018168725,-0.07271312,-0.061576266,-0.020313125,0.070800334,0.044864416,0.06686429,-0.013717403,0.01608302,-0.035054456,-0.0094163,-0.02226884,0.111982055,-0.040061135,0.017185625,0.035025507,0.03516665,0.026212126,-0.072725445,-0.051553242,0.0132922875,-0.016843678,-0.03383398,-0.027247626,-0.0484589,-0.03897832,0.012400043,-0.03319603,-0.04486679,0.024153674,-0.10935026,0.03751452,-0.015596327,-0.08273912,0.06086583,0.012302041,0.097385444,0.06348487,0.03855689,0.10604063,0.0500809,-0.041239347,0.021297608,-0.028856067,-0.050055217,0.047033872,0.07825629,0.0704827,0.08540696,0.012739522,0.006751349,0.069021404,0.025992619,-0.042979117,-0.025417289,-0.021017874,0.13710001,-0.055020317,8.638368e-06,0.063694306,-0.033239454,0.08863418,0.0049571022,0.08368924,0.029144716,0.008579215,-0.009940002,0.03810347,0.052677266,0.082029164,-4.9637896e-05,0.041785125,0.025557844,0.013176478,-0.023840891,-0.047260996,0.10555189,0.0071415864,-0.110805415,-0.050758768,0.01167836,-0.00470739,-3.970362e-33,0.05804718,-0.04600166,-0.007910193,-0.1568437,-0.06261573,0.0241575,0.01852028,-0.0039288523,-0.0012141649,0.052289885,0.08849199,0.005011772,-0.017299933,-0.075939186,0.02682284,-0.03546958,0.0036004072,0.022933243,0.015263699,0.019212883,0.029458415,0.06638017,0.03831853,-0.006096519,0.048920374,-0.011524073,0.006157785,0.013895438,0.06969607,0.048540056,-0.036280103,0.040666007,0.009460155,0.027319506,0.03722002,0.07669228,-0.03927861,0.043857843,0.029418204,0.041615408,-0.009245054,0.00087039726,0.02899579,0.057187565,0.03905662,0.096162096,-0.12112267,-0.00865641,0.013640841,-0.00677313,-0.023584666,0.036934145,-0.006939325,-0.03037681,0.026553513,0.0052138097,-0.013244014,0.009011966,-0.0027554475,-0.12608278,-0.04960794,0.002455819,0.032787066,0.038534798,-0.0057930066,0.11402294,-0.040420704,0.025033956,-0.0005361111,0.04509063,0.0014809178,-0.03966396,-0.0027076355,0.0021048868,-0.0045241644,-0.06997741,-0.019274008,-0.011554824,0.05818354,0.022261873,0.019471578,0.036632866,-0.012153137,-0.058364697,-0.05710678,-0.12453254,-0.05306768,0.119563594,0.03250268,-0.012842864,-0.037062537,0.05370058,-0.034694783,0.021907197,0.08322946,-3.8665696e-08,-0.015255432,-0.08878043,0.07728861,0.003266483,0.036034856,0.011892807,-0.008012568,0.005719686,0.05935906,-0.06373977,0.069550954,0.085818745,0.027467275,-0.021935305,0.024208646,-0.013058235,0.027520638,-0.0045762253,0.019701442,-0.03337056,-0.06879948,-0.0077121826,-0.035248116,0.034465052,0.029197764,-0.07280689,0.02168433,-0.046952244,0.02270453,0.013197157,0.0027236447,0.028946826,-0.08544423,-0.020614611,0.023156522,0.0074961074,-0.130607,-0.023575462,0.00606877,-0.06359842,-0.00842507,-0.056675877,-0.017422574,0.03982577,0.06980656,0.027042363,-0.021873789,0.024335017,-0.005393119,-0.004245767,-0.024595272,0.009975397,0.075313605,-0.0959911,-0.11137679,0.0047523496,0.02390691,-0.11760717,-0.0621192,-0.025667468,0.049586695,0.07509996,0.21323693,-0.0046855183 +1.14.15.45,"The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The vertebrate enzyme catalyses two hydroxylations in the pathway at the positions meta to the prenyl side chain (the other hydroxylation is classified as EC 1.14.15.46, 2-methoxy-6-polyprenylphenol 4-hydroxylase). The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.",384,1.0,0.00835581,0.032786172,-0.009545578,-0.00925293,-0.015961105,0.0256148,-0.07133022,0.021332426,0.024713168,-0.070702404,0.04678483,-0.013674117,-0.05961158,-0.014340332,-0.044137154,0.042254005,-0.07843039,-0.017553307,-0.013093089,-0.025953894,0.085004285,-0.034736592,-0.020419482,0.028799415,0.027082503,-0.054131616,0.04668296,0.029881574,-0.015208935,-0.034799837,0.018260282,-0.07300832,0.032753546,-0.08071525,-0.015161667,0.07684449,-0.02078648,-0.038310133,0.04273266,0.042943463,0.08779826,-0.098737046,-0.03587877,0.10349564,-0.025772236,0.04043551,-0.06928807,0.07999188,0.074071296,0.043690097,-0.041427024,-0.03867479,0.019407922,0.060327448,0.032400347,0.06902563,-0.045201227,0.042200234,-0.0042933132,-0.026537107,0.044627037,0.029588768,-0.005333103,0.013382552,0.023307784,-0.0053045256,0.0023459073,-0.054421827,0.028795775,0.0028232315,-0.008116672,-0.0392345,-0.09280669,0.04485234,-0.07400135,0.0013085946,-0.062602,-0.007276401,-0.0018916605,-0.052004874,-0.0107173035,0.02049167,0.055031132,0.02019433,0.052254707,0.017888956,0.06876926,-0.018778866,0.009094904,0.038027592,-0.0027455476,-0.08958082,-0.0029219422,-0.018045038,-0.015571568,0.041772705,0.06741617,0.082005754,0.010973317,-0.037242968,0.030649982,-0.007421305,-0.030466981,-0.09096067,-0.04706852,0.027087118,-0.018643238,0.055413608,0.048805952,0.015153867,-0.033401474,-0.0032128366,0.02196786,0.018419826,0.0074566593,-0.006235987,0.008503516,-0.018725976,-0.03913204,-0.03707466,-0.032624144,0.045462586,0.048510525,0.077775374,-0.013264796,-0.008240239,-0.13997309,1.4712832e-33,0.04734556,-0.010233963,0.01109271,-0.04822703,-0.06125807,0.022223383,-0.0640891,0.03693149,-0.12972693,-0.033913035,-0.060123537,-0.004042217,0.0051801032,0.057778113,0.043151498,-0.047204208,0.06247037,-0.01876709,0.092618555,-0.031171242,-0.07949901,-0.026823688,-0.02898285,-0.07386304,-0.053483434,0.0057129557,-0.062116917,0.004899214,-0.0237018,0.029929789,-0.04170078,-0.10037976,-0.08872959,0.035629828,0.0057176854,-0.048011076,-0.04221677,-0.061527036,-0.012260246,0.038931094,0.047361266,0.052985005,0.026145749,-0.06074699,0.06752633,-0.03121043,-0.032507718,0.13810189,0.051998608,0.01473289,0.029364645,0.044529647,0.110053815,-0.052661717,-0.10070556,0.016949954,0.026011325,-0.011913014,-0.04131276,0.06122743,-0.050108884,0.11228174,0.005747202,0.0066349776,-0.005306999,0.036055993,-0.05454773,-0.011976523,-0.014980315,0.045998923,-0.030481666,-0.035707593,0.031116594,0.026311258,0.0070849513,-0.0464589,-0.038834065,-0.024628816,0.06480157,0.0176245,-0.08400481,-0.026565332,-0.0145234475,-0.042920277,-0.002529263,0.03701469,0.042928666,-0.06407141,-0.01968236,0.081269145,0.04801894,-0.06914302,-0.05788267,0.060010098,0.04998075,-3.7368793e-33,0.049792096,-0.102405064,0.050466083,-0.0617657,-5.539049e-05,0.06811053,0.031139879,0.031930808,-0.023728343,0.018540533,0.11583172,-0.013325309,-0.018444385,-0.027129218,0.056048036,0.018760819,0.014942027,0.082302764,0.07748666,-0.05460126,0.046403974,0.033965122,-0.020054603,0.0431031,0.015120909,0.0014266403,0.048383597,0.017633699,-0.01390137,0.054884933,-0.046517152,0.012306916,-0.045687303,0.02279898,-0.030808087,0.023528446,-0.11659992,0.072022095,0.107351266,0.017532295,-0.00035632015,0.0028212995,-0.00917472,-0.0026418897,0.029417006,0.08044492,-0.05910108,0.07265922,-0.046374686,-0.060449235,0.061398573,0.04528811,0.009195708,0.02453118,-0.0095744915,0.031154204,-0.023415757,0.00781757,0.027261896,-0.06960719,-0.015049114,-0.039004095,0.05502172,0.024018494,-0.0031988854,0.06558377,-0.041569743,0.03563693,-0.04414232,-0.06558122,0.07321194,-0.028782489,-0.015418537,0.022074372,-0.054374225,0.007218584,-0.054736886,-0.07957372,-0.0019508834,0.023156954,-0.015545452,-0.025958003,-0.0056984015,-0.08203874,-0.06467628,-0.08506487,0.045290183,0.10751779,-0.032809168,0.10575788,0.021661134,0.07000693,-0.104665555,-0.0034620399,0.13641332,-4.1709765e-08,0.03122837,-0.046948437,0.095974624,-0.04586784,0.023073731,0.020202516,-0.022428032,0.046700485,0.02493546,0.010191387,-0.003490854,0.05071361,0.0021265831,0.052223805,0.01526353,-0.015229924,0.038461898,0.013185289,-0.020885982,0.0052363533,-0.09761301,0.031754926,-0.06806097,-0.04494874,-0.037810996,-0.11310833,0.079632595,0.07481258,-0.023598822,-0.0523022,0.014373746,0.015163126,-0.08513273,-0.05193109,-0.05930126,0.08144677,-0.050130237,-0.072100885,0.0019520102,0.012933232,-0.045060933,-0.10266129,0.011731324,0.038001798,0.04226475,-0.0049733547,0.05987084,0.040168896,-0.030794147,-0.0184601,0.026087109,-0.052977562,0.05759988,-0.116970174,-0.05179627,0.035091974,-0.08057562,-0.071918964,-0.028095735,-0.062012177,0.02804773,0.013138618,0.21150848,-0.04641028 +1.14.15.46,"The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The vertebrate enzyme catalyses two hydroxylations in the pathway at the positions meta to the prenyl side chain (the other hydroxylation is classified as EC 1.14.15.45, 4-hydroxy-3-polyprenylbenzoate 5-hydroxylase). The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.",384,1.0,0.006435379,0.028261708,-0.015306334,-0.0076199295,-0.009940145,0.022702973,-0.06428713,0.01852091,0.018670533,-0.06352316,0.055193298,-0.008662296,-0.063848026,-0.0041293735,-0.049872644,0.036105722,-0.075236894,-0.009529902,-0.013119324,-0.026952611,0.086965874,-0.027353652,-0.010774214,0.037701406,0.027055988,-0.048654296,0.050667554,0.03688654,-0.012689841,-0.047834296,0.017290542,-0.08255514,0.0364187,-0.08463562,-0.020668609,0.07525099,-0.028648738,-0.0402721,0.04222238,0.043238677,0.088054374,-0.107047185,-0.034263264,0.09942416,-0.02432778,0.040620644,-0.067008734,0.07326433,0.07649134,0.046540853,-0.038183965,-0.036879197,0.017222563,0.06158077,0.01988567,0.057833515,-0.039932393,0.040655952,-0.014884261,-0.03083126,0.041247398,0.031250834,-0.007978916,0.007919259,0.017505715,-0.0011245848,-0.008883425,-0.04943061,0.023102036,0.003535624,-0.0043697697,-0.04707624,-0.08822795,0.04658576,-0.074992344,0.014612818,-0.052586447,-0.0036969546,-0.018630076,-0.04970245,-0.013528517,0.012542065,0.056367062,0.023795314,0.045845494,0.022817513,0.061390787,-0.0066199135,0.014313367,0.037869703,-0.003877344,-0.07223278,0.009626158,-0.005906014,-0.016036307,0.041494966,0.06358447,0.08620764,0.010310868,-0.040306393,0.03754762,-0.0055407607,-0.023598794,-0.08815151,-0.04098784,0.029912606,-0.017315125,0.058568068,0.048788972,0.0018452205,-0.048210934,-0.0012158583,0.022984372,0.020609587,0.012615108,-0.01739798,0.013771025,-0.01084123,-0.036645073,-0.03225171,-0.03244607,0.052727617,0.044422552,0.07007557,-0.016828464,-0.0064158654,-0.15064177,1.5719673e-33,0.045908242,-0.005969881,0.0035564594,-0.043802984,-0.07015041,0.031296656,-0.06938797,0.030682454,-0.12760761,-0.038335577,-0.059542462,0.0009179941,0.00503121,0.048030876,0.03424062,-0.046474855,0.053953774,-0.014139247,0.09351512,-0.031287648,-0.07943376,-0.026499366,-0.044391148,-0.07977655,-0.047814824,0.0031993538,-0.05521278,0.00494487,-0.034089833,0.025402201,-0.048215855,-0.09754692,-0.098359525,0.021944614,0.01946372,-0.051214166,-0.025145438,-0.053678073,-0.015494313,0.038949594,0.04227977,0.047428485,0.019795077,-0.049893856,0.066266835,-0.028802449,-0.030837744,0.1548104,0.05667126,0.008825251,0.037253607,0.040715344,0.113470145,-0.04681024,-0.09912833,0.019071132,0.020563684,-0.007268417,-0.035801273,0.054683458,-0.047853842,0.10864219,0.006443115,0.0074398257,-0.0063352813,0.03278537,-0.05079585,-0.019600341,-0.011958961,0.045219287,-0.036019463,-0.0369284,0.035179224,0.03443373,0.014011014,-0.05332921,-0.046062198,-0.029837832,0.072115086,0.023344541,-0.09237828,-0.030172525,-0.026228188,-0.040712763,-0.0020978006,0.048569016,0.041161314,-0.06723377,-0.023844354,0.076259024,0.06089812,-0.07369817,-0.05240322,0.050579727,0.05218783,-3.635504e-33,0.05216838,-0.10197123,0.041132852,-0.050968423,0.0025592053,0.059878282,0.030009678,0.03712677,-0.032140285,0.016404185,0.11341888,-0.01296687,-0.017332496,-0.030194664,0.05222574,0.019080382,0.014484289,0.075613365,0.08229874,-0.06353057,0.04636841,0.034229554,-0.020582018,0.044087004,0.007096079,0.019943468,0.04258075,0.021060368,-0.01617739,0.06069221,-0.04674758,0.015316011,-0.047595378,0.012588743,-0.030217834,0.03298609,-0.11286265,0.0715858,0.1012031,0.0077157835,-0.007304506,-0.004108196,-0.012526579,-0.0029862155,0.024424782,0.08869792,-0.05308471,0.07718629,-0.03874473,-0.06004163,0.05780318,0.04908077,0.008596664,0.023181524,-0.006999674,0.022953674,-0.020856712,0.017225446,0.030243209,-0.06148185,-0.004861066,-0.03433693,0.062831946,0.018944912,-0.0020326907,0.062088083,-0.035975672,0.03597913,-0.028994262,-0.06261045,0.069044285,-0.03060638,-0.0016296527,0.030689605,-0.054508608,0.01833903,-0.0439867,-0.079918005,-0.007181284,0.021121932,-0.011840839,-0.029341217,-0.002171056,-0.07473841,-0.0722109,-0.08355933,0.041627448,0.107596196,-0.03732863,0.103336155,0.028534465,0.07400229,-0.10500534,0.0038908385,0.13027139,-4.1602974e-08,0.03324954,-0.050640352,0.09091285,-0.05292461,0.020785386,0.034511857,-0.031879056,0.044862054,0.039702777,0.0136859,0.0026345719,0.04617574,0.006897846,0.06528643,0.012419347,-0.018453343,0.045612782,0.0188538,-0.019136826,-0.005407722,-0.107459806,0.036508534,-0.07979402,-0.05143701,-0.031014225,-0.110662565,0.07392373,0.08367252,-0.014741849,-0.04966047,0.014176728,0.016390407,-0.080800235,-0.051391266,-0.052123044,0.092239454,-0.049193334,-0.07410167,0.0027650215,-0.00042993188,-0.055786144,-0.099070705,0.007870323,0.038388986,0.035940062,-0.011946704,0.06402366,0.04564867,-0.033929896,-0.037101608,0.027069299,-0.050892204,0.060067844,-0.11938381,-0.053396676,0.04151969,-0.07643706,-0.072912015,-0.028466491,-0.062348295,0.018040037,0.00845373,0.20316212,-0.04789826 +1.14.20.16,The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew).,384,0.99999994,0.026999494,-0.037280414,-0.08737736,-0.02380763,-0.006880582,0.035346534,0.0022758502,0.016969893,0.06169355,0.033253826,0.023705494,0.027522009,-0.05725938,-0.011539202,-0.005478382,0.020733038,-0.050969563,-0.008620919,-0.0084521165,-0.0073786597,0.16442992,0.009689063,0.081201516,0.063977085,-0.05847025,-0.070030995,-0.041582383,0.013904367,-0.012740418,-0.08491651,0.026483983,0.008148715,-0.031934593,-0.012427247,0.033054035,0.03696193,-0.02467943,-0.0020834822,0.056466646,0.050645437,0.04219796,-0.06251721,-0.10787404,-0.024139531,-0.0979479,-0.08343627,-0.022648629,-0.050862234,0.10400316,0.08768316,-0.06526235,-0.073277704,-0.05428387,0.015111473,0.009783874,-0.0046300367,-0.022036927,-0.024865225,-0.014998975,-0.046106953,-0.018655697,0.020362493,0.0035269256,0.02420227,-0.021779208,0.038305152,-0.037303954,-0.019089833,0.0057645305,-0.08647316,-0.057969116,-0.0706051,0.03677106,0.04084559,-0.06807526,0.010158394,0.043098215,0.071330786,0.060150087,-0.096732125,0.04163757,0.05795205,0.024863448,0.10624089,0.037698362,0.014049579,0.07740755,-0.0066916337,0.10641366,0.008894337,0.03694647,0.029859506,-0.02065164,-0.0010725611,-0.021676287,-0.03393242,0.06253629,-0.045741223,-0.0026763438,-0.011377853,0.02149432,-0.0059223063,0.0034860012,-0.14659198,-0.06967752,0.05926153,-0.11352372,0.05429858,0.015965618,-0.03484564,-0.0074893115,0.030286476,0.016803553,0.08093409,-0.00094507507,0.11715449,-0.050187413,-0.096504495,-0.0820737,-0.091171496,-0.030344492,-0.07737287,0.02713573,-0.017700823,0.009812989,0.015731875,-0.01598847,-3.214374e-33,0.04387508,0.00058664416,-0.011606563,-0.072680674,0.042224515,-0.0338712,-0.015756954,0.047360435,-0.1340501,-0.012526832,-0.08667987,-0.07055259,-0.043369908,0.027289044,0.027667942,0.015802221,-0.014389837,0.018095013,-0.0017672554,-0.017868733,0.015838556,0.07435636,-0.0038991566,-0.038335845,-0.05709889,0.09934669,-0.041089263,-0.015000219,-0.005151052,0.0031043098,-0.0070910035,-0.11136282,-0.025562506,0.033397123,0.018590996,0.067117356,-0.0035123827,-0.039717305,-0.013960338,0.029441046,0.03969226,0.025683608,0.083243795,-0.054032397,0.0015046025,-0.030138515,-0.01992324,0.02401422,0.0774335,0.043219734,0.009579716,0.01957249,0.07871263,0.0034996576,-0.080771394,0.055934638,-0.04690406,0.022989662,-0.012453341,-0.0047129346,0.042059805,-0.014318905,-0.011138845,0.038449965,0.0032907946,0.052453425,-0.072805874,-0.00864497,0.033009157,0.10598759,-0.07761935,0.011900483,-0.0008060777,-0.005488353,0.06515148,-0.024242757,-0.0093976,-0.010160069,-0.02937559,0.06632798,-0.032451626,0.0029625678,-0.05142094,0.06256732,-0.049207326,-0.021987427,0.025597122,0.048312765,-0.057569113,0.005369382,0.044858072,-0.06643614,0.0017810431,0.03947288,0.012750168,2.3836006e-34,0.07395594,-0.0969779,0.07789289,-0.04314858,-0.05209646,0.12558767,0.019795047,-0.019751025,-0.01652851,0.0355629,0.027974077,0.06720682,0.04322896,-0.032345243,-0.03821582,-0.027214829,0.051393606,0.047315244,-0.05062408,-0.048583556,0.0022063206,0.12728536,0.017692858,0.061201435,-0.025755702,-0.007744138,0.057085793,0.082587436,-0.033545252,0.022289883,0.047333945,0.05173717,-0.050187923,-0.017901467,0.0015419701,0.019695442,-0.030265857,-0.05065158,0.007484653,0.041970603,-0.042652268,0.0065650055,0.012461409,-0.012135565,0.043869704,0.0017738241,-0.1058473,-0.0033501394,-0.05446482,0.038879093,0.06357606,0.04214838,-0.00077613816,-0.0019606354,0.008629563,0.06486313,-0.035589814,-0.015142196,-0.0051987562,-0.02463285,-0.07678065,-0.0057607414,0.006005221,0.017200736,-0.010719421,0.022562992,0.010267795,-0.031579185,0.09493555,0.0057596886,0.06283198,0.057586662,-0.06800301,0.081774816,-0.0049219783,0.019178974,-0.023499325,-0.07573057,0.027974224,-0.0206289,0.03495533,-0.011471544,0.038514696,-0.11097902,-0.044351436,-0.0073159155,0.0054568443,0.09752791,0.054241493,-0.00384668,0.033043742,-0.100065984,-0.030929597,-0.021912348,0.02687861,-2.4628875e-08,-0.00968599,0.014847213,0.02472421,0.031317692,-0.05715266,-0.012830492,-0.011506026,0.013292903,-0.015205916,-0.07584168,0.06358011,0.05173933,-0.011331784,0.050727718,-0.00077228463,0.010693291,0.025089273,0.079814136,-0.045123223,-0.039581403,-0.08912538,-0.049377125,-0.09364802,0.08954568,0.023069445,-0.08557312,0.025082545,0.042638626,0.024432357,0.0060398974,0.0002686705,0.009588582,-0.057955973,-0.038008336,-0.056203526,0.06366681,-0.0046292823,-0.015290032,0.048514124,0.06760596,0.07366895,-0.07867468,-0.035500538,-0.041755214,-0.042639505,0.03793783,0.027607223,-0.056383543,-0.00061774283,-0.012213888,0.044897653,0.010966554,-0.02476742,-0.09217088,-0.15224548,-0.011476004,-0.042556558,-0.06709309,-0.02241028,-0.102734774,0.07597615,-0.015203583,0.1981501,-0.03899879 +1.97.1.15,"The enzyme, characterized from the bacterium Escherichia coli, catalyses three hydroxylation reactions in the oxygen-independent pathway for ubiquinone (UQ) biosynthesis. The reaction involves an electron acceptor whose identity remains unknown as of 2024. The Escherichia coli enzyme is a heterodimer, with both subunits containing a [4Fe-4S] cluster that is essential for activity and may serve as part of an electron transfer chain from the substrate to the unidentified electron acceptor.",384,0.99999994,-0.06357996,0.040027242,-0.08158132,0.037551627,-0.0025562115,0.008415948,-0.047235243,-0.035198543,0.025931207,-0.10701629,0.029057652,-0.05563941,-0.00023563285,0.031131865,-0.04190337,0.039512914,-0.091658026,-0.017556114,-0.006667059,-0.07295966,0.054785505,0.015568267,-0.015099249,-0.055535223,0.040948987,0.023228614,0.09690594,-0.021747414,-0.034419496,-0.054480784,0.049673226,-0.04912628,0.03859947,-0.11603703,0.019815823,0.09037277,-0.0067683947,-0.11641078,0.053521033,0.0021425472,0.004753557,-0.0310186,0.015340072,0.06053342,0.035185806,0.020981168,-0.004497811,0.04420473,0.07715265,-0.038001254,-0.027150722,0.012365746,-0.035792578,0.060182247,0.052211605,-0.0076040905,-0.03514763,-0.016865823,-0.0011003541,0.0035127162,0.06660044,0.009055151,0.05783592,0.044675466,0.014978009,-0.037756536,0.006044225,-0.08502069,0.007100046,-0.054814044,-0.04944285,-0.06132042,-0.058651365,-0.02952819,-0.04389986,0.022214657,-0.034217846,-0.009407118,0.07092918,0.024216494,0.0060653267,-0.08381808,0.018021135,0.06447442,0.039608754,0.028701669,-0.019038029,-0.04811887,0.03421315,0.03791516,-0.02387704,-0.07922179,-0.008010802,-0.011413203,-0.00040812095,0.008597998,0.065726,0.0722106,0.04000055,-0.0009830649,0.038375888,0.06937238,-0.06345454,-0.05693959,-0.03712354,0.025154881,0.07578396,0.16031186,0.01837018,-0.018672097,-0.029629044,-0.06084273,0.011196487,-0.0048050294,-0.02554861,0.05552708,0.08701874,-0.058375586,-0.07014112,-0.03440162,-0.019080112,0.025738435,0.018202804,0.010916262,-0.021567913,-0.037818316,-0.13529342,2.027135e-33,0.071555704,0.04366963,0.008337766,-0.051772475,-0.012679206,0.05256376,-0.07822737,-0.011940884,-0.11683308,-0.030977733,-0.039747763,-0.028708147,0.06232623,0.03734133,-0.022019701,-0.057033196,-0.02608562,0.008074621,0.0850672,0.0044659018,-0.0070880353,-0.013648001,-0.030452527,-0.00055774295,-0.016059738,0.05737088,-0.022042714,0.026256487,-0.0075286534,0.007950482,-0.0053863055,-0.034999933,-0.13436267,-0.030919,-0.0043202667,-0.026566312,-0.062172722,0.0018588491,0.014263192,0.003476964,-0.034790356,0.07480467,-0.049255095,-0.04618315,0.11058357,0.006247544,0.00861626,0.080371566,0.052851353,0.036367945,-0.006363685,0.018825958,0.11301872,-0.097897716,-0.06491473,-0.0010238902,0.03741041,0.069803715,-0.0016761331,0.03190219,-0.028173618,0.09998156,-0.060315344,0.053118296,-0.013634905,0.029703738,0.030746719,-0.023259318,-0.02721758,0.13106449,-0.026411105,-0.0036214693,0.05666703,-0.010337465,0.028410297,-0.037670016,-0.094537966,-0.02128357,0.057094265,-0.042521052,-0.023863064,-0.024716793,0.002837571,-0.026524607,-0.014392736,0.019273741,-0.030723238,-0.011279926,-0.011772264,0.11125549,0.08400654,-0.03444735,-0.028434535,0.009190847,0.054581117,-3.7427358e-33,0.077357404,-0.04892457,0.020760583,-0.1161667,-0.02733556,0.016947493,-0.006209983,0.013625781,0.0838019,0.024644949,0.08329627,0.02919897,0.02436386,-0.054864217,0.023840662,-0.01097814,-0.029054005,0.04532444,0.04243039,-0.0011538785,0.10740886,0.04027314,-0.03723397,-0.03328554,0.043928374,0.039241992,0.0012729338,-0.0048128404,0.0804904,0.02395777,-0.037419908,-0.07210567,-0.007655625,0.0057196426,-0.014920912,0.047630236,-0.04354202,0.108268715,0.10548494,-0.0064720176,0.007310896,-0.016010115,-0.04741106,0.07999622,0.058652803,0.10385089,-0.072015844,0.074601285,-0.054302447,-0.034872714,0.00033777056,0.0039918823,-0.049033236,-0.015945831,-0.00794438,0.0770514,0.014968712,-0.030746369,0.006076271,-0.031630702,-0.011092606,-0.05487735,0.07756102,0.013536677,-0.044541623,0.025699502,-0.008514415,0.045165867,-0.00016288912,-0.055328347,0.063924134,-0.02581475,-0.045163248,0.029572532,0.012737232,-0.027337473,-0.08152502,-0.07718754,-0.011848809,0.047850534,0.014242968,0.008487444,0.019730903,-0.06918959,0.019374728,-0.10866287,0.047599293,0.10460189,-0.0010869032,0.05505742,-0.008348875,0.055223785,-0.033217944,-0.0012015844,0.015891882,-3.9492818e-08,-0.0075315326,-0.07301608,0.04954557,-0.057134178,0.030455966,0.069490954,-0.04170194,0.016775597,0.08894337,0.0035857095,0.042120155,0.042964764,-0.006054141,-0.037700392,0.0887859,-0.014657055,-0.0004745205,-0.04475049,-0.0147540085,-0.021648398,-0.048242178,0.016117126,-0.095103055,-0.009957315,0.002009515,-0.06257459,0.04853057,0.0059080315,-0.06154469,-0.043167178,-0.030241093,0.045310944,-0.03653282,-0.04115442,-0.11787828,-0.059862196,-0.03411623,-0.08825924,0.026230387,-0.028286628,-0.024825115,-0.03315395,-0.082733594,0.039114922,0.009600229,0.0704787,-0.001961889,-0.021687148,-0.051215895,-0.002652176,0.058358148,-0.109034054,0.034112822,-0.03643316,-0.09032307,0.08097852,-0.06965454,-0.04978987,0.011007691,-0.11274139,0.05048903,0.010401134,0.17173727,-0.042071607 +2.1.1.397,"The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine. It can methylate 10-hydroxystrychnine, and, with lower efficiency, 11-hydroxystrychnine and 11-demethylbrucine.",384,0.99999994,-0.013962404,0.006098144,-0.18090564,-0.09199318,0.024295546,0.07960085,-0.06954787,0.029534701,0.044601344,-0.02635465,-0.008285436,-0.044366393,-0.105426684,-0.022838514,-0.045034554,0.05098562,-0.07826728,0.0055175344,-0.0012305634,-0.10473498,0.048645735,0.09113363,-0.024701657,0.056736566,0.0006495053,0.016547853,0.053719003,-0.041564103,0.048008226,-0.09615961,0.035350166,-0.0015899423,0.074281625,-0.057685822,0.056077633,0.05865576,-0.02844923,-0.089614384,0.073861405,0.06323395,-0.013848658,0.024373647,-0.019759243,-0.008204398,-0.08671146,-0.028635148,0.017918259,0.0700898,-0.047197726,0.028850982,0.03494477,-0.07560157,-0.042172022,0.06504819,0.019423258,0.08331512,-0.0694281,-0.023988448,0.021975484,0.026375223,0.056558616,0.06744895,-0.0067781014,-0.0064829024,-0.038666774,-0.020991864,-0.012191537,-0.019909002,0.033483736,-0.10451462,0.016594334,-0.10712502,-0.07372725,0.01829568,-0.005553713,0.025629746,0.034158256,-0.033960856,0.009018678,0.0002621476,0.0207628,0.013833435,0.034159422,0.06100507,0.053744134,-0.024174169,-0.02869759,0.063962616,0.0420088,0.04583108,0.029963255,-0.026770145,-0.0047091637,-0.04779652,-0.044579364,0.039861966,0.015216881,-0.013205086,0.0014662321,-0.023203349,-0.016014151,0.01177236,-0.0057419334,-0.04630695,-0.09676776,0.034744572,0.0033938924,0.06380277,0.06023691,-0.01443356,-0.052339032,0.061228164,0.0037468069,0.027545052,-0.0067039896,0.060888376,0.079721026,-0.06657558,-0.03908915,-0.04045615,0.021389682,-0.01322212,0.03404782,0.03423256,0.010930054,0.052804947,-0.10549551,4.3206144e-34,0.06787121,0.04625363,-0.010864554,-0.021861108,0.009345747,-0.026657877,-0.06324781,0.027738856,-0.0700448,-0.04935799,-0.113185845,-0.08666445,0.040290415,-0.03398103,0.04987585,-0.0059550446,-0.037064105,-0.0072416374,0.029002272,-0.014317311,-0.01651637,0.080474444,-0.07062413,0.027636753,0.0067086797,0.040638424,0.011584169,0.034701493,0.093381,-0.027945183,0.0020135066,-0.07359355,0.0021017788,-0.0042484514,0.09065061,0.046202864,-0.02070801,-0.030935904,-0.007969709,0.055716842,0.017235296,0.034973003,0.0032173097,-0.041360367,0.034452733,-0.072447665,-0.08220859,0.016474672,0.042640485,-0.014736962,0.0025840714,0.059351537,0.078874186,0.037961554,-0.030298669,0.037841137,0.009995745,-0.01303152,0.054801278,0.059100304,-0.00088299136,0.0216928,0.03612955,0.033378355,0.05493581,-0.04098716,-0.0845659,-0.0568482,-0.04634899,0.04646023,-0.0931084,-0.066133045,0.005044526,-0.104811534,0.04790272,-0.03940632,-0.026904054,0.01988949,0.016966624,0.016265292,0.049704514,0.005302401,0.043841932,-0.025256818,-0.01095213,-0.03162918,-0.029386511,-0.057561595,0.013932301,0.06817263,0.0016148186,-0.06331068,-0.008765293,-0.029809933,0.0731689,-1.755089e-33,0.006461046,-0.1175419,0.017914046,-0.044530485,-0.022944557,0.11141897,-0.0063815345,-0.08378926,-0.03144216,-0.03160729,0.06265214,0.056360472,-0.049136218,-0.063532375,0.03289431,-0.006074203,0.0707521,0.12639156,-0.019031025,0.0045763804,0.008623962,0.0921599,-0.038510576,-0.019978218,-0.0073963543,-0.027424501,0.014353379,0.07243728,0.11539726,0.018438889,-0.006515031,-0.012928024,-0.022517983,-0.024605533,-0.03754316,0.06044122,-0.03383838,-0.01634046,0.0014259802,0.00150649,-0.00676341,-0.032757714,-0.023367206,0.055430796,0.037102625,0.063250005,-0.07762286,0.01285499,-0.067213565,0.029031891,0.09570314,0.0004439576,0.018197333,0.048435643,0.055027228,-0.040400065,-0.0003189946,-0.0020192682,0.04305495,-0.052883,-0.03352631,0.021286849,-0.07160139,-0.043124914,0.07271359,-0.005915091,-0.09915043,0.055588104,0.07170821,-0.021916134,0.05758089,0.06383504,-0.016341759,0.105925806,-0.017322797,-0.04532255,-0.069305405,-0.037194736,-0.0019144093,-0.031038977,-0.058310207,0.011617988,0.04293465,-0.10833726,0.024454407,-0.09436935,0.0388861,0.0971796,0.036066074,0.06515063,-0.029395415,-0.013574982,-0.063178636,0.041303612,0.04032424,-3.62319e-08,-0.062021565,-0.093622334,-0.056406815,-0.057435498,-0.044558518,-0.0023972641,0.06095512,0.012311769,0.03830304,-0.0124924965,-0.009998127,0.033478245,0.052329067,0.0018801496,0.021656582,0.05029037,-0.03176807,0.010031073,0.022626052,0.032266658,-0.02637544,0.0884256,-0.06663012,0.048589565,-0.022349883,-0.06228476,0.024576744,0.080275066,0.021670783,0.011418415,0.0645913,0.051964022,0.032821182,-0.055230316,-0.054860763,0.030623078,-0.0048204004,0.036161654,0.016383633,-0.0094539905,-0.0031384958,-0.022042066,-0.11464222,0.034043692,-0.075684905,-0.021342833,-0.011045628,0.06700823,0.0033639614,-0.0052889287,0.015643183,0.0035844238,0.0129732555,-0.05760516,-0.07677979,-0.02225933,0.04785003,-0.14844237,0.013157631,-0.08338679,0.0211831,-0.033656202,0.19513553,-0.017219113 +2.1.1.398,"The enzyme catalyses a step in the biosynthesis of 3'-methoxypuerarin, an isoflavone with bioactive properties isolated from the roots of the leguminous plant Pueraria lobata var. leguminosa. The highest activity has been found for 3'-hydroxydaidzein. The enzyme has low activity on the 3'-hydroxyflavones luteolin and quercetin. 3'-hydroxypuerarin is not a substrate.",384,0.99999994,-0.077562384,-0.095975935,-0.15286855,0.005520474,-0.0034893274,0.055192742,-0.108839266,0.019531153,0.014106154,-0.07453705,0.025577864,-0.025777064,-0.08601459,-0.07669684,-0.08249368,0.044345666,-0.02268972,0.05629971,-0.0053768996,-0.026890187,0.06362523,-0.06720717,0.026785495,0.055681277,0.07299726,0.03296388,-0.02371802,-0.009818197,-0.012420984,-0.044767946,0.009060632,0.0019005401,0.023159927,-0.030089678,0.0304342,0.09617639,-0.0017362986,-0.045964226,0.08857863,0.033288117,0.03190168,-0.07932743,-0.012796558,-0.08995875,0.023201404,-0.039507985,-0.03413713,0.04698753,0.008056276,0.019432085,-0.019647568,-0.017882487,-0.00838032,-0.029986668,0.023124998,-0.09541683,0.05271552,0.029551802,0.011820026,0.078122094,0.028404647,0.024813304,-0.017057808,-0.014991,0.007400671,-0.11567983,-0.0533639,-0.029328033,0.05553492,-0.0005844681,-0.014524661,-0.05379973,-0.026122238,-0.012659556,-0.069509126,0.06726587,-0.039179772,-0.021783188,-0.0033953283,-0.06045673,0.076466545,-0.012209262,0.01412392,0.14375032,-0.0038829497,-0.036958538,-0.040830918,-0.008022339,0.0046725315,0.09483171,0.027387436,0.099309675,-0.0015068243,-0.019630015,-0.059649136,0.1034003,-0.013313157,-0.0031487518,-0.029748032,-0.019308051,0.00534706,-0.0091251,0.009570657,-0.07619818,-0.04303705,-0.02383586,-0.022547562,0.006788419,0.097870626,-0.009017421,-0.07583398,-0.014307729,-0.053458713,0.029288871,-0.050709553,0.086630404,0.030949704,-0.113842055,-0.051002264,-0.057968076,-0.03068022,-0.025528258,0.09387417,0.056078944,-0.013759258,-0.03537956,-0.0058371485,3.8191797e-33,0.10013364,-0.0033990324,-0.047438513,-0.01339437,-0.01325109,0.023588885,-0.044343203,0.045608673,-0.017469315,-0.015853835,-0.08515202,0.014123686,-0.033936054,0.016155733,0.005724845,-0.036036868,0.015282594,-0.044770405,0.080151245,-0.041866437,0.08219503,-0.04138498,-0.093629636,0.0250985,-0.026641032,0.015797988,-0.045726955,0.045705367,0.035760615,-0.02864954,0.060669538,-0.10252219,0.025331005,-0.016990641,-0.0081217345,0.013793401,-0.015624554,-0.057032,-0.05938753,0.059862267,0.03961633,-0.02273901,0.053803667,-0.05088764,0.044281755,0.07478364,-0.08612035,0.001018579,0.022117758,-0.001910923,0.026653904,0.0057031675,0.1487864,-0.0031963773,0.009812777,0.021087488,-0.024147233,0.038654797,0.06377075,0.06911648,-0.015740694,0.012896886,-0.00077977026,0.03313501,-0.021090966,0.0134772835,-0.048795134,0.044842955,0.05177142,0.04341087,-0.012619942,-0.0070692017,-0.016265497,0.020385006,0.09090039,-0.048162427,-0.016394358,-0.007042223,-0.04018467,0.023842636,-0.032493003,0.030166002,0.024187857,0.012871551,-0.04717533,0.06861773,-0.054365,0.024427025,0.0022401295,0.019438349,-0.02418789,-0.066213675,0.010660285,0.01911704,0.041123644,-4.3191053e-33,0.03480368,-0.07451648,0.041418307,-0.06265313,-0.040439304,0.10567322,-0.036450796,-0.0330811,0.015708204,0.044669956,0.03417834,-0.052674916,0.027500277,-0.045671258,0.021942193,0.031169645,-0.001230412,0.049313944,-0.021135446,0.05092673,-0.06103601,0.06342148,0.008818579,0.069242716,0.036260013,-0.043780103,0.10457611,-0.07415211,-0.020785835,0.08358427,0.005775495,-0.03920336,-0.027494324,0.06247498,-0.056134716,0.040393714,-0.061125115,-0.011149993,-0.012413118,0.00829863,0.0068474747,0.021595182,0.005123585,0.0430225,0.082637906,0.04174664,-0.103125975,0.009271087,-0.0566066,0.023081081,0.05702645,0.0057871523,0.021687856,0.058669962,0.11265169,0.0020043023,0.046728957,0.0030915067,0.042172607,-0.0687176,-0.019866547,-0.014864949,-0.06410353,-0.007675322,0.081936516,0.13371989,-0.021358747,0.115690656,-0.019463211,-0.036314167,0.10213125,-0.024130017,0.007402422,0.097436935,-0.0004695547,-0.0020877235,0.014498662,0.017055204,-0.009863085,-0.034015596,0.015694939,-0.021352999,0.007930575,-0.14464779,-0.057417247,-0.032697003,0.026729217,0.08100452,-0.00962946,0.056192268,0.010244937,0.037715957,-0.03970481,-0.0363272,0.060471464,-3.8699753e-08,-0.0038187625,-0.030640032,0.06646188,-0.01993168,0.047158167,-0.0034210759,0.034718458,0.003434014,0.029915107,-0.02798957,-0.025220072,0.038670607,0.026249314,-0.025149874,0.063143,-0.05465791,0.0580988,0.0716023,-0.0009142127,0.080965064,-0.081808455,0.080360346,-0.08663222,-0.03437132,-0.00019842309,-0.04998881,-0.010121357,-0.055551857,0.074961595,0.05835818,0.05825553,0.031365957,0.024807619,-0.05501989,-0.08379312,0.05572334,0.010794772,-0.06038727,-0.054614007,0.034892544,-0.07405703,-0.08663445,0.007672858,-0.0573764,-0.09718938,-0.0044716937,-0.006631982,0.020286925,-0.0058425763,0.03375913,-0.024471108,-0.058742426,0.07563852,-0.10573004,-0.050589878,-0.0434109,0.038977105,-0.07902299,-0.047309775,-0.049412273,0.0100297015,-0.015373305,0.13290255,0.07764229 +2.1.1.399,"The enzyme occurs in the roots and leaves of the plant Acorus calamus (sweet flag). In additon to trans-reveratrol it is active toward isorhapontigenin and shows slight activities toward piceatannol, oxyresveratrol, and pinostilbene.",384,1.0,-0.060475428,-0.109014764,-0.1307642,0.061969135,0.009197011,0.049480483,-0.014021028,0.00796888,0.047010694,0.023579745,0.15546596,-0.011298904,-0.14669807,-0.0089268945,-0.07193363,0.052751932,-0.058408223,-0.027636213,0.011185896,-0.093856454,0.0773221,-0.03348247,0.029219478,0.031083714,0.041618463,-0.02360056,-0.022124248,0.034055967,0.04001128,-0.07759131,-0.01233447,0.0084794145,0.041217588,-0.004471954,-0.013485528,0.09238858,0.0070189107,-0.10120904,0.058031905,-0.0034633195,0.03485606,-0.06580349,0.00873878,-0.010587499,-0.03160691,-0.09101294,-0.015759934,0.021520143,0.09483544,-0.003895304,0.011573375,-0.012961989,-0.040806945,0.047185957,-0.06031804,0.04484434,0.06514119,0.003281891,-0.023893215,0.0060940357,0.06129479,0.018236825,-0.040819537,0.006569873,-0.015468939,-0.029129222,-0.05780424,-0.0008428783,0.051638775,-0.04801335,0.003076113,-0.08449592,-0.004124042,-0.008619871,-0.03193721,-0.034616586,-0.048110127,0.001472989,-0.013594684,-0.013732182,0.02092631,0.02713507,-0.0045626373,0.08586585,0.020397227,0.0015794802,0.008046718,0.022839984,0.037080966,0.046040177,0.026063772,-0.008814213,-0.0018334418,-0.042167008,-0.013897231,0.036754884,0.023227591,-0.08055389,-0.01777521,-0.025498563,-0.00070926617,0.059699785,-0.08752285,-0.12341284,-0.033019863,0.097647585,-0.106456734,0.0024122582,0.017223136,-0.021467177,-0.02686846,0.045815825,0.0314208,0.027198363,-0.02008141,0.073494494,-0.026649818,-0.049854066,-0.066801116,0.012021543,-0.034055684,-0.049819425,0.00353568,0.064008325,-0.025919456,0.0193207,-0.09041385,2.7985793e-33,0.07310879,0.01637587,-0.04799393,-0.044381056,0.01242032,0.007115829,-0.05753459,0.041235402,-0.06927151,-0.036966585,-0.044384632,-0.062708616,0.018756438,-0.010591017,-0.021216908,-0.03986035,-0.028992066,0.0013116637,0.040359594,-0.011645636,-0.011728654,0.0754249,-0.08403598,-0.05916618,-0.035553485,0.12302343,-0.0018279256,0.03500307,-0.004845409,-0.0049434192,0.09659409,-0.07408855,-0.083219945,0.05385658,0.08253805,0.048808992,0.022141088,-0.10153074,-0.059024543,0.044727374,0.035027076,0.040828608,-0.001003097,-0.019774647,0.05779617,-0.040798094,-0.054673817,0.06586141,0.14710958,0.0788342,0.028733058,-0.008046288,0.08921855,-0.00053559867,-0.044939842,0.027872074,-0.059120335,0.021200344,0.03434052,-0.0075551374,0.0052649723,-0.019416226,-0.02518979,-0.016171366,-0.030514024,0.08216526,-0.07040117,-0.017266555,-0.0017101059,0.056872718,-0.08618143,-0.028629646,-0.047768738,0.057193156,0.08280126,-0.018047767,-8.852501e-05,0.05916721,-0.031243503,0.008714738,-0.07189687,-0.05985379,0.016833788,-0.0053221304,-0.009232203,0.011264743,-0.032907818,-0.026464216,0.003828394,0.021977412,0.056595188,0.021890735,-0.04421101,0.08276791,0.010743279,-3.8038347e-33,0.040723648,-0.11071407,0.0022127752,-0.10191747,-0.10033392,0.035045754,-0.025581986,0.01389073,0.0038611023,0.019093882,0.046896506,0.022650573,0.027302545,-0.044949982,0.008033597,0.064736694,0.029202783,0.086799845,0.002743626,-0.008051801,-0.1181293,0.13928004,0.07703374,0.0017988591,0.033289917,-0.00054091605,0.050782505,0.04722003,0.0021834166,0.026603498,0.039504398,-0.043919317,-0.05235177,-0.0118206525,-0.050599907,0.033014935,-0.050414074,-0.030780613,0.024287652,0.12564138,0.0014459924,-0.01916652,0.031502515,0.055484347,0.037913382,-0.016328458,-0.1320519,0.05141248,-0.08176609,-0.01109976,0.06387987,0.00418675,0.033826508,0.0670456,0.10106035,0.063192174,-0.00062773353,0.024906242,0.0001864538,-0.02835186,-0.02206611,-0.03354958,0.021952378,-0.043692727,0.08082628,0.07008663,-0.04091402,0.033008423,-0.0078055323,0.011807662,0.1204787,0.019805118,-0.00021613741,0.021772228,0.0026748076,-0.018180989,-0.047586083,-0.02568257,-0.047031432,-0.07974092,-0.071963705,0.01657958,-0.005904126,-0.0863085,-0.05629046,-0.045120962,-0.012683838,0.08147476,0.010640434,0.021520846,0.015623159,0.049590744,-0.042639524,-0.037032768,0.10643966,-3.4486515e-08,-0.041834105,-0.07308368,0.06338981,-0.036284618,0.041368987,0.037979092,0.047465812,0.0017721017,-0.036209747,-0.022966275,-0.025814675,0.09098352,0.026048806,0.0048741307,0.011511753,0.008431138,0.0054713413,0.07566108,-0.024141414,0.05858575,-0.058421202,-0.00036155613,-0.03667221,0.033769287,-0.04363566,-0.015809163,0.10052793,0.014105193,0.006694525,0.024687061,0.065015234,0.06053795,-0.0050582252,-0.021057026,-0.086948484,0.11277028,0.024893807,-0.06248737,-0.058993522,0.020527944,-0.03734079,-0.020323133,-0.02774618,-0.019860322,-0.04764095,-0.006381855,0.050600357,0.022080429,0.0018738976,0.01372515,0.051413342,-0.048747566,0.00083723775,-0.07957711,-0.07918237,-0.0155075025,0.032212526,-0.06106138,0.0004022981,0.04280278,0.016011652,0.0011895988,0.13530351,-0.03862584 +2.1.4.4,"The enzyme, characterized from the bacterium Salinispora tropica, participates in the biosynthesis of ketomemicins. In vitro the enzyme could use multiple other amino acids, including L-cysteine, L-isoleucine, L-leucine, L-methionine, L-tyrosine, L-phenylalanine and L-tryptophan instead of L-valine.",384,1.0,-0.01900838,-0.044615746,-0.080490395,-0.08064299,0.00567177,0.08441596,-0.027921977,0.01362429,0.07972677,0.009070797,0.043230075,-0.08196496,-0.0037646897,-0.005677243,-0.074756004,0.051209275,-0.04953548,0.05454772,-0.0053247674,-0.04212783,0.08447183,0.012532879,-0.05824781,0.026067441,0.05652644,0.015129308,0.034930006,0.020021386,-0.065057896,-0.09167975,-0.034217797,-0.041389085,0.056014344,-0.07653774,0.10143861,0.10572713,-0.13132901,-0.038921315,0.09058912,0.072333194,-0.011425314,-0.06331451,-0.0030426579,-0.0022179782,0.009081813,-0.06847135,0.012179439,0.06162202,0.060174093,-0.010880564,-0.041389287,-0.095484234,0.010428743,-0.019288095,0.0064998,0.0022736737,-0.1271983,-0.039313044,0.006706274,0.02773352,0.018611265,0.05829689,0.039089214,-0.045281682,-0.009806997,-0.09882046,0.0125831785,-0.107430495,0.022763072,-0.041738193,-0.036156412,-0.069878355,-0.018671107,0.06168142,-0.008626433,-0.004081065,0.0033722457,0.00709509,-0.050166238,-0.020447588,0.059042055,0.04730618,-0.028592546,0.035639282,0.07369003,-0.016296148,0.0325922,0.04790253,0.08792642,0.0036667632,0.04679331,0.0035401294,-0.0257178,-0.071669295,-0.08379169,0.006836747,-0.07423396,0.026533458,-0.022184098,-0.037990887,0.00927237,0.005192819,-0.041356873,-0.06999539,-0.055780526,-0.028535109,0.017298417,0.04882367,-0.039413184,-0.049785685,-0.031012438,0.012615664,0.0023151198,-0.008176912,0.0050296895,0.07318111,0.068475,-0.09131905,-0.037544187,0.017587733,-0.02099202,-0.041120417,0.05800869,0.08030939,-0.015240297,0.08855058,-0.06557753,2.6944083e-33,0.10486779,0.05158384,0.006829822,-0.01669512,0.019022202,-0.046769224,-0.036368933,-0.026039295,-0.039996177,-0.1256022,-0.10320525,-0.018841824,0.023342075,-0.0068267104,0.015441232,0.06782629,-0.012066054,-0.048803918,0.049110975,0.051931653,-0.033256188,0.032250613,-0.009949367,0.07172042,-0.021234225,0.06313426,0.014873626,-0.023136627,0.06636329,-0.0044058873,0.027467856,-0.042111736,-0.04821084,0.012980647,0.077521406,-0.035966106,-0.0074327732,-0.003117827,-0.023689425,0.08861813,-0.06064777,0.06181933,0.013398026,0.010312175,0.04513606,-0.007417752,-0.028656144,0.064806715,0.08763338,0.005718186,0.08412727,-0.03189434,0.0866521,-0.020063015,-0.05529727,0.09377547,-0.018260913,0.0063674664,0.009871471,0.0704799,-0.08501738,0.037184108,0.014998528,0.012096473,0.03193858,0.011964652,-0.07178052,-0.021314649,0.03270475,0.052507702,-0.09441762,-0.07592105,0.034769673,0.03052868,0.007379116,-0.056149937,-0.08934855,-0.01062457,0.007243819,-0.0028598197,0.05547111,-0.0826469,0.006964619,-0.001890811,-0.0026334259,-0.018381542,-0.04608476,-0.058651518,0.051809404,0.030077513,-0.0040416853,-0.037958954,-0.101265445,-0.018902611,-0.011280911,-4.406047e-33,0.096527785,-0.10452161,0.013056304,-0.009981932,-0.06967702,0.11584933,-0.05078891,-0.0794713,0.007741319,0.029244171,0.051618446,-0.053340435,0.017276114,-0.03417252,-0.021409992,-0.07322,-0.0035677254,0.09171879,-0.075074434,0.0038615693,-0.048650682,0.021957358,0.029707367,-0.03444398,0.060280193,0.02529489,-0.060746428,0.09909394,0.03737553,-0.0016997745,0.023068137,-0.01401555,-0.051800635,-0.06124261,-0.0041650645,0.03760169,-0.038621895,-0.0005213144,0.061970733,0.035202287,-0.0108048385,-0.02488272,0.073391505,0.029513698,0.024201673,0.04571149,-0.028557986,-0.033652328,-0.03251277,-0.11202885,0.040166978,-0.025685312,0.010042772,-0.022620292,-0.033083625,0.015996596,-0.019170027,0.010391598,0.06045297,-0.0147558,-0.014573526,-0.11423369,0.041889787,-0.009474547,0.0444913,0.047195133,0.0130803995,0.058670543,-0.009595676,0.0039991,0.0009192,-0.035691816,0.08378175,0.07549597,-0.055020638,0.0012982558,-0.11061606,-0.06538986,0.052183256,-0.012297644,-0.03172822,-0.052762058,-0.016203918,-0.05283617,-0.012182796,-0.025071248,0.05489881,0.072578825,0.03515374,0.021080613,0.016858857,0.0040197815,-0.019700153,0.03741827,0.04363605,-4.4479435e-08,0.11255437,-0.051063325,-0.0024000132,-0.02539039,-0.0083653,-0.0122652305,-0.028182533,0.00828376,0.06709553,-0.022552107,-0.016499018,0.113445505,0.022965347,0.03502236,0.038520254,0.07641536,0.025260905,0.017919995,0.022221098,0.060046412,-0.07196965,-0.0107255755,-0.094074726,0.012426327,0.03298238,-0.055365454,0.05015032,0.07403122,0.028877111,-0.015710834,-0.00368884,-0.026066352,0.045954105,-0.031560197,-0.047835216,0.06272882,-0.113920294,-0.03165544,0.05930777,-0.0060713505,0.029781887,-0.010935663,-0.09392091,0.014152694,0.0060712625,0.058125857,0.014011288,0.038422007,-0.04092547,0.007404956,-0.03472626,-0.03719531,-0.017804215,-0.015522134,-0.082178235,0.040714435,0.057910383,-0.12168803,0.027803669,-0.09130251,-0.032774955,0.046710372,0.15200803,0.020438815 +2.1.4.5,"The enzyme, characterized from the bacteria Micromonospora sp. ATCC 39149 and Streptomyces mobaraensis, participates in the biosynthesis of ketomemicins.",384,1.0,-0.052516274,0.022831108,-0.1390067,-0.029086763,-0.039554507,0.04622282,-0.02974259,0.029113652,0.08498042,0.02035363,0.048475165,-0.09873887,-0.03916218,0.014343866,-0.053848494,0.037760988,-0.003707722,0.0035615154,0.06312556,-0.061420027,0.13481498,0.023724245,-0.040922236,0.005388807,0.054258868,0.058413684,0.040296458,-0.010795632,-0.0871368,-0.08146439,0.0044820923,-0.012652955,0.085702755,-0.08100752,0.13414688,0.11566786,-0.07341809,-0.029235251,0.14103362,0.0017762216,-0.00078863907,-0.025444305,0.020983355,0.01840291,-0.07368676,0.0449677,0.013003331,0.10059459,0.0047986633,-0.032650013,-0.048724234,-0.06533471,-0.009574208,0.010430192,0.082528844,0.013367921,-0.062166486,-0.051153954,0.0018212221,-0.0066126017,0.054531537,-0.0069754985,0.050139513,0.029253297,-0.022020182,-0.0745496,0.01349374,-0.10350865,0.04369056,-0.04185002,-0.0730048,-0.063594565,-0.003927993,0.06744198,-0.0065269475,0.031505946,-0.013207562,0.015631342,-0.0042760214,0.0001329165,0.071907885,0.0008728183,-0.023465773,0.04334097,0.06287904,-0.062261496,0.052123174,0.001012248,0.093052894,0.013953058,0.0054924246,0.010169658,-0.042893518,-0.06670181,-0.072383694,0.001356817,-0.074712485,0.05362086,0.020209098,-0.027602589,-0.027220864,0.025474744,-0.0054505123,0.001060273,-0.061590675,-0.056543503,-0.0035864685,0.06825013,0.065804936,0.02609451,-0.016490623,-0.008545768,-0.019491635,-0.006280552,0.037808172,0.04893851,0.08452159,-0.06317511,-0.028790787,0.043408524,-0.01354315,0.018345341,-0.00457891,0.040216174,-0.027948026,0.06821078,-0.09212584,1.4787839e-33,0.030743083,0.06150594,0.033319216,-0.033758216,0.041528292,-0.10129308,-0.034209274,-0.0585702,-0.048661143,-0.06647143,-0.08765173,-0.057756647,0.0016562284,0.0277766,-0.005339929,0.02649404,0.047368567,-0.025268061,0.05320767,0.009644523,-0.025346339,0.020735677,-0.041125417,0.013069295,0.023616124,0.11653633,-0.058679074,-0.007271628,0.07023812,-0.017686334,0.039426725,-0.024721991,-0.05307562,-0.0020747308,0.08612587,-0.059150886,-0.054116912,-0.050011717,-0.0056548296,0.032784794,-0.084282935,0.035499115,-0.037192587,-0.02695151,0.031543124,-0.026017694,-0.076344036,0.029802091,0.10467159,0.041479334,0.049400534,-0.033408258,0.098607,-0.018102886,-0.034030665,0.06600579,0.025379082,-0.0017590328,0.018637536,-0.024036095,-0.049368814,0.020908168,0.010778846,-0.0077070594,0.07964511,-0.024416044,-0.044924993,0.02986457,-0.03610775,0.070061326,-0.058155634,0.020132892,0.004661648,0.031286072,-0.02570059,0.013863826,-0.0665801,-0.05495447,-0.029456493,0.017677136,0.006614697,-0.061851945,-0.035250846,-0.09644046,-0.030526143,0.003248369,-0.061520223,-0.036448985,0.057376035,0.025033202,-0.03570654,-0.08845144,-0.09963803,0.02117409,-0.03732336,-4.6048092e-33,0.11906455,-0.06320954,0.021941954,-0.03689411,-0.046410277,0.1391063,-0.06563032,0.019796455,-0.037103917,0.043110978,0.018481893,-0.017494703,-0.036922593,-0.03757811,-0.012395286,-0.035478625,0.003791917,0.116374806,-0.031552695,0.030310147,0.023520438,0.1252796,-0.01589098,-0.009791495,0.014379602,-0.0148389265,-0.0027696753,0.10727765,-0.0044587525,0.006051859,0.027728604,-0.055262946,-0.024752421,-0.06316103,0.0013440573,0.026085839,-0.0138100535,0.024320144,0.08586266,-0.013505923,0.031073257,0.008726725,-0.008448032,0.05440696,0.050800692,0.041357044,-0.06400579,0.027700732,-0.0018349652,-0.06700987,-0.025689652,0.012487389,-0.015673362,-0.013653505,-0.06322257,-0.011846563,0.006406109,0.0098522045,0.03216045,-0.03380089,-0.044998635,-0.110724166,0.042665243,-0.009861623,0.048836205,0.09904657,-0.037844826,0.07197715,0.034185138,0.017032493,0.005824987,-0.06068727,-0.070976615,0.052793577,-0.027831342,-0.00841953,-0.07576723,-0.01406235,0.049511544,0.037226375,0.012516799,-0.034570098,0.04446755,-0.031193761,0.0192861,-0.03228807,0.07024293,0.031417757,0.0012594312,0.044549435,-0.014145525,0.03021365,0.020842051,0.005921153,-0.04965411,-3.2458832e-08,0.098186895,-0.057950772,0.06317935,-0.025474872,0.042821165,0.015567655,-0.07271847,-0.02097316,0.091097385,-0.022597086,-0.0038197804,0.028570792,0.02575169,-0.001872869,0.044742838,0.011121234,-0.04375886,-0.04143415,0.020525167,0.0006095317,-0.0687893,-0.0127039915,-0.073226295,0.044951756,0.07468641,-0.061300874,0.037407093,0.060285266,-0.051318333,0.029600155,-0.0038039396,0.061454836,-0.0105402395,0.053476784,-0.114966676,-0.023775741,-0.07902403,-0.053334042,0.022707492,-0.02981805,0.0015989365,-0.037234426,-0.06699164,-0.0049174577,-0.054226242,0.11256773,0.014988777,-0.017535059,-0.06543099,0.034193594,-0.067550994,0.009416897,-0.04444249,0.02678159,-0.11919916,-0.011559684,0.040681142,-0.037683196,-0.040003393,-0.12087281,0.049656253,-0.011277503,0.13942842,-0.016889028 +2.3.1.324,"The enzyme has been purified from Solanum lycopersicum (tomato) fruits. In the vacuole, at pH 4-5, it produces 3,5-dicaffeoylquinic acid from cholorgenic acid. In the cytoplasm, at pH 6-7, it can use aromatic acyl-CoAs as donors and catalyses the reaction of EC 2.3.1.99 (quinate O-hydroxycinnamoyltransferase). The initial product, 3,5-dicaffeoylquinic acid, undergoes spontaneous acyl migration to form 4,5-dicaffeoylquinic acid. Small amounts of 1,5-dicaffeoylquinic acid are formed as a byproduct.",384,1.0,-0.0973193,-0.042858772,-0.04879811,-0.058924526,0.079224005,0.034038633,-0.031318102,0.047745593,0.06814904,-0.029592823,0.0979185,-0.0848928,0.043509707,-0.055376455,-0.06046806,0.08241154,-0.05719083,0.020984694,-0.066270046,-0.05966247,-0.042992342,0.011511586,-0.025677452,0.016211795,0.06821757,-0.03917961,-0.055438515,0.028380722,-0.07827259,-0.07680482,0.013683902,0.014640045,-0.0107648475,0.0067525455,-0.038067244,0.06499199,-0.028465081,-0.06535335,0.10904434,0.032515407,0.04496584,-0.0028211426,-0.061451964,0.033976793,0.057491187,0.035021443,-0.0069175283,0.0018554742,0.037939098,0.034717306,-0.056327686,0.037996482,-0.031121185,-0.005004342,-0.045459285,0.038444042,0.020026335,0.05937924,0.01605445,0.06285159,0.0077246935,-0.014553435,-0.011600809,-0.024037777,-0.13195992,-0.025638841,-0.011805325,-0.062317476,0.0895849,-0.029257592,-0.09219044,-0.07903539,0.033107787,0.0049923365,-0.0052312403,0.08153702,-0.049006626,-0.0049401154,0.0146098705,-0.009709395,0.019814545,0.020208078,-0.087759234,0.052888613,0.0005345707,0.007856924,-0.00095955137,-0.06655263,0.063529015,0.055905167,0.029056707,-0.0062229163,-0.065978944,-0.034395542,-0.077999115,0.049862258,0.03579793,-0.079248525,0.046867564,0.0008111606,0.015328444,-0.008883295,0.004549714,-0.11586882,-0.099327855,-0.0048540807,-0.007481165,-0.01463016,-0.043287754,-0.015406846,0.020493034,-0.012517298,0.0049827476,-0.055205446,-0.006412461,0.13518465,0.012653661,-0.054432373,-0.038898997,-0.053357996,-0.035148885,-0.013844159,0.061432198,-1.7824104e-05,-0.080543816,-0.021463146,-0.013270547,4.457925e-33,0.02675345,0.057086915,0.018578237,0.0336885,0.016881479,0.012412208,-0.08186212,0.08847701,-0.022628367,-0.08139046,-0.05628593,-0.0740389,-0.021518175,-0.024716014,-0.071992315,0.011526379,-0.0359517,-0.06888011,-0.008749746,-0.016624376,-0.028292824,-0.014627571,-0.06264114,-0.003014453,-0.03474346,0.033467457,-0.027436234,-0.0025007613,0.06978522,-0.014406079,0.010533435,-0.035704277,0.0009032625,0.005995927,-0.022370918,0.055983912,-0.04164454,-0.026688358,0.0059447414,0.08886354,0.0062600626,0.07348495,0.0397601,0.010294601,0.04243054,0.023942547,-0.0016006904,0.09873577,0.028555289,0.013058141,-0.0017549765,-0.010107508,0.10024622,-0.011793264,-0.018714607,0.01944975,-0.0015159807,-0.0068707895,0.022144059,0.013539125,-0.014444003,0.052828353,0.018962909,-0.023722759,-0.005298005,0.02991346,-0.122349456,-0.037514284,0.043743093,0.018445767,0.01816979,-0.049871907,-0.011213381,-0.02103968,0.059864294,-0.026083963,-0.05353537,0.024750773,-0.0048294943,0.021120323,-0.03705218,-0.0072715636,0.08519952,-0.018722417,-0.029127019,0.022144403,-0.024098933,-0.02376956,0.033217236,0.039926704,0.05336739,0.0042834817,0.040619522,-0.006351015,0.035223708,-4.7159008e-33,0.06787377,-0.02727702,0.019396422,0.006881832,0.0034330995,0.021301739,-0.06951219,-0.022832416,-0.0038163126,0.013557786,0.0052694706,0.0007257849,0.067041405,-0.047319986,0.010947457,0.017134173,0.062315796,0.14567313,-0.03997394,0.062064536,-0.04693363,0.084507704,0.012098202,0.00022789193,0.06558503,0.014672567,0.0069573997,-0.05234128,0.021157695,0.07616583,-0.03976055,-0.020796025,-0.026720244,0.036091253,0.0700261,-0.018965287,-0.056134123,-0.013415787,-0.016614601,0.11102232,-0.072426,-0.016654963,0.03471843,0.009888282,0.028623441,0.044189997,-0.042131137,0.038618535,-0.044039857,0.029218119,0.07082878,0.04257599,-0.09293934,0.018477147,0.041299056,0.10919272,0.03192998,0.020127697,0.034812115,-0.07963852,-0.05664938,-0.10607492,-0.021727113,-0.09446655,0.023618968,0.11587176,0.04254903,0.11224787,0.0040219133,-0.05572477,0.07177898,0.024036905,0.027557248,0.01912314,-0.044067077,0.00021487645,-0.031978477,-0.04488773,-0.025439082,-0.0076067764,-0.061192494,-0.07360337,0.021612965,-0.076619655,-0.055408414,-0.092018306,-0.051123895,0.022813225,-0.035501383,0.084042065,-0.022801876,-0.021202363,-0.003744696,0.06190429,0.14613092,-4.361393e-08,0.014625484,-0.05899981,-0.0075152824,0.03991388,0.032292955,0.010735914,-0.01880186,0.06390495,0.07648988,-0.0023485487,-0.025721043,0.069912985,-0.008003548,0.047217377,0.029623488,0.050160646,0.064986244,0.09347265,-0.02320511,0.045856856,-0.08293031,0.026000632,-0.089997835,-0.043758363,0.042878665,-0.095687665,0.027497886,0.02707012,-8.620176e-06,-0.06330608,0.023274804,-0.008774185,-0.03668361,-0.089544445,-0.07124398,0.04266723,-0.023328094,-0.054539133,-0.0012496971,0.017927434,-0.027639491,-0.0046539586,-0.09296313,0.04001449,-0.048761297,-0.019395048,0.047513988,-0.018558234,-0.038585633,0.06377747,0.048108794,-0.009760919,0.1448858,-0.06276326,-0.06393761,0.01777061,0.05539184,-0.023891114,-0.038544405,-0.043250795,-0.080233805,0.08680661,0.21153939,-0.049115043 +2.3.1.325,"The enzyme, characterized from the tree Strychnos nux-vomica, catalyses the last step in the biosynthesis of strychnine. The product, prestrychnine, undergoes a slow spontaneous decarboxylation and cyclization, forming strychnine.",384,1.0,0.01207392,0.03300232,-0.14184234,-0.044761393,-0.022552678,0.03995369,-0.06943416,0.0345065,0.10049108,0.014618987,0.0007716142,0.014874233,-0.08951785,0.014037196,-0.07840367,0.0061930884,-0.08165423,0.02346104,-0.010289086,-0.06531066,0.08198432,0.07669941,-0.03735535,0.012909128,0.04262933,-0.005835905,-0.011818287,-0.03362487,0.07396427,-0.060419954,0.063113466,0.024685003,0.109523974,-0.034466725,0.035028566,0.05413545,-0.047052965,-0.088408336,0.08022457,0.06591892,-0.010026106,-0.0016469049,-0.06843307,0.068177395,-0.095484756,-0.037463214,0.035126504,0.061662503,-0.027512763,-0.043964542,-0.0023382988,-0.029073061,-0.083187886,0.03255698,0.010082563,0.09701502,-0.062605284,-0.013967088,-0.008824338,0.009736541,0.036418762,0.04148637,-0.02830582,0.011894032,0.029371144,0.018340122,0.039782908,-0.02414155,0.0988975,-0.012279896,-0.016057724,-0.038044035,-0.03360047,0.00073812885,-0.013822862,0.03028089,0.04026904,0.0036883196,-0.040354267,-0.010188392,0.08006961,0.03856861,0.022394907,0.05518011,0.057333477,0.06574157,-0.07946136,0.07176789,0.07309582,0.03462186,0.01143372,-0.023684975,-0.008837825,-0.026127882,-0.044700857,0.016940223,-0.00082748715,-0.035914488,0.047212742,0.00039636772,0.017448692,0.0014499185,0.019881787,-0.01202959,-0.030291967,0.006123722,-0.03250912,0.044202812,0.007622318,0.067158066,-0.038846657,0.014763986,0.019372938,0.022002244,-0.051058218,0.08856435,0.018484704,-0.032530207,-0.016137132,-0.047101714,0.06033618,0.00880149,-0.049162287,0.02436331,0.0007171506,0.04935707,-0.11470747,2.011053e-33,0.015787186,0.06263421,0.047079477,-0.0063369134,-0.020750565,-0.014289349,-0.016175088,-0.007154041,-0.055010248,0.027795242,-0.093806036,-0.09254648,-0.0029900393,-0.034486603,0.0203746,-0.06934954,-0.027189404,0.015661955,0.018812878,-0.0063267383,-0.022117302,0.08618189,-0.08416609,0.0046442356,0.023707597,0.03666745,-0.04391416,0.0033784118,0.06631095,-0.025460875,-0.05984406,-0.072844125,-0.0346345,-0.04104845,0.07727423,-0.008038262,-0.03315323,-0.05338643,0.05684377,0.04980476,-0.02637323,0.029861242,0.008224349,-0.00804688,0.0021148934,-0.0746192,-0.12168046,0.046401992,0.03349399,0.0015935438,-0.0025561918,0.027857149,0.061376538,0.06320621,-0.06805604,0.030046437,-0.00090579636,-0.055105068,0.026738618,0.034267135,-0.023606839,-0.034598887,-0.020601604,0.020410007,0.027166398,-0.041908808,-0.10317947,-0.057444215,-0.030620832,0.08688192,-0.110928185,-0.023592712,0.0020812177,-0.08065306,0.057343565,0.023102218,-0.040568274,0.04517955,0.047291297,-0.018416036,-0.0019641162,0.00056037947,-0.054325603,-0.0338812,0.0036022575,-0.036903903,-0.00045222745,-0.070829146,-0.0039263368,0.115453415,-0.036116414,-0.090720356,-0.03943851,0.022914056,0.07412493,-3.0139784e-33,0.053783696,-0.10824618,0.01876325,0.005361052,0.02171294,0.07091164,-0.048405867,-0.09332816,-0.07029913,-0.049898677,0.031520043,0.017468113,-0.010707163,-0.0147414375,0.0030189871,0.023774827,0.113197766,0.13852187,0.026161106,0.008484428,-0.0032522038,0.06840775,-0.06674336,0.0028433031,0.003064158,-0.07695993,0.079445615,0.06244903,0.061232444,0.07301732,0.023372183,-0.027802117,-0.04178133,0.0132872965,-0.064111345,0.11554189,-0.0030183715,0.008750758,0.068571754,-0.02150301,0.051243547,-0.0111612845,0.005433021,0.036145423,0.03624649,0.055757564,-0.093369305,0.05147365,-0.0121625,-0.04449815,0.08608453,0.029009314,-0.0009979262,0.033521146,0.037872046,0.03187311,0.048285544,-0.08074049,0.032928858,-0.041458514,-0.015480869,-0.035761897,-0.02785464,-0.064238936,0.06294904,-0.08149748,-0.032851264,0.09278418,0.077313565,-0.06333268,0.05571369,0.10503769,-0.061086666,0.09088481,-0.019252898,-0.05777865,-0.0880885,-0.06439488,0.03500819,-0.07026,-0.06997665,-0.0039118505,0.05014408,-0.05376739,0.019502882,-0.075757764,0.103624634,0.080369905,0.0004109621,0.048752416,-0.021611927,-0.011895507,-0.020774256,0.0699638,0.039335348,-3.439008e-08,-0.044613343,-0.058470435,-0.036297478,-0.052649446,-0.019344456,0.035580695,0.054672286,0.02810166,0.025991114,-0.06504958,-0.027543753,0.005685701,0.05996259,-0.008204931,0.038960345,0.07388891,-0.08886219,-0.009178413,0.009387332,0.0036284202,-0.014655856,0.061535507,-0.078993075,0.006402681,-0.028450526,-0.056634124,0.04488111,0.08169051,0.004240555,0.02528645,0.008048725,0.042399652,0.02496024,-0.036321126,-0.059632443,-0.020408941,0.012814287,-0.017554564,0.058767114,-0.025633259,-0.018382262,-0.029321723,-0.10551913,0.0297939,-0.106309466,-0.019644102,0.028375592,0.035734557,-0.009315435,-0.021599324,0.069501884,0.026688805,-0.032624118,-0.02392878,-0.026290271,-0.022989914,-0.0091553945,-0.047972336,0.012607365,-0.07704214,0.015931647,-0.00975715,0.1877552,-0.041868243 +2.3.1.326,The enzyme has been characterized from a nonstrychnine-producing Strychnos sp. (Strychnos potatorum).,384,0.99999994,0.048694782,-0.052138977,-0.24306834,-0.039374553,0.016695665,0.0729272,-0.049086012,0.04757403,0.03798749,-0.037289836,0.06645381,-0.03161392,-0.061328508,-0.017251402,-0.10104529,-0.026398405,-0.024619836,-0.033848163,0.008565693,-0.09591386,0.031094741,0.07616703,-0.007575731,0.007009215,0.032654688,0.01656838,0.019193698,-0.051414084,0.008543598,-0.04168252,-0.03124719,0.010340632,0.05991973,-0.013886969,0.065583386,0.024462102,-0.047253203,-0.08001311,0.041200936,0.03303297,-0.010310161,-0.0048215045,-0.07893757,0.08164859,-0.07856683,-0.020251285,-0.0018806503,0.028247487,-0.018884908,-0.05623843,-0.026168684,-0.06053283,-0.015172317,-0.009198077,-0.005713406,0.040882833,-0.069319814,0.028755875,-0.044245586,0.017319439,0.025775542,0.04100547,0.028244447,-0.011507595,0.028279481,0.015873352,0.010714739,-0.011900372,0.047073808,-0.043973505,-0.042848583,-0.04897939,0.031653386,0.015572507,-0.037831534,0.02954246,0.00352547,0.034214366,-0.002745014,0.030809924,0.04720824,-0.018432127,-0.015471196,0.07766266,-0.0010306435,0.086561225,-0.06608431,0.07301009,0.024272587,0.062290683,0.05194531,-0.041534103,-0.04639367,-0.032275308,-0.047744934,-0.0014097132,-0.008623849,-0.043449223,-0.02287623,-0.028561976,-0.050178334,0.052945517,0.04179849,0.027009027,-0.01719741,0.030191693,-0.06861477,-0.01014117,-0.004934691,0.036103394,0.042496778,0.097518325,-0.02166425,-0.04045968,-0.0148310745,0.001150819,-0.0029914773,-0.062021796,0.0069340207,0.0008267062,0.059077986,0.05547681,-0.023604766,0.072884664,-0.019621039,0.03425553,-0.077265225,-7.454586e-35,0.0042472575,0.06479714,0.047054816,-0.092153415,-0.004881553,-0.021725494,-0.054370977,0.05350927,0.05270327,0.013349774,-0.08926513,-0.100750126,0.049711727,-0.044692,0.06913148,0.023868857,0.008681866,-0.016433507,0.07991346,0.034395058,-0.0121298395,0.050022904,-0.07408801,0.010427278,-0.00750837,0.012357658,-0.04522467,-0.04415646,0.064788505,-0.04430071,0.015449739,-0.044605017,-0.014853627,0.034309354,0.070430264,-0.024134664,-0.037547782,-0.031810585,0.049792953,0.03485073,0.0272914,-0.015223392,0.05101784,0.03455335,0.060819905,-0.09993125,-0.05364682,0.023482706,0.017008057,0.009000379,0.0047088275,0.0057309824,0.08934232,0.06424847,-0.03192807,0.012074691,0.029621676,-0.035515036,0.008375939,0.05892359,-0.06964292,0.02542412,-0.020946508,0.013777869,0.0040801144,-0.025613127,-0.16226058,-0.062176593,-0.016750246,0.05162573,-0.039956514,-0.061222862,0.03564428,-0.0532762,0.038015686,-0.01004669,-0.080635026,0.09829617,0.026706833,-0.011066899,0.020256288,-0.03780701,-0.022255063,0.0052320384,-0.05830356,0.04519098,-0.04447783,-0.060850445,0.032786675,0.11680152,0.0002627163,-0.04156399,-0.07960178,-0.011892891,0.07931207,-1.8228512e-33,0.085538685,-0.108364716,0.00056077016,0.0041139354,0.060463767,0.09888275,-0.01572183,-0.01768241,-0.0007176782,-0.03327878,0.022079445,-0.0045945155,-0.04848748,-0.0885535,-0.0148070175,0.11282457,0.008621938,0.15973791,0.009916934,0.018172814,-0.04232445,0.12066545,-0.015056794,0.019553956,0.029065236,-0.060349323,0.07161476,0.036916956,-0.038559325,0.017251914,0.090927996,-0.083812326,-0.01289851,0.0025288954,-0.0491108,0.06306429,-0.011757983,0.005794136,0.046198383,0.027100965,0.028249044,0.053705804,0.005463104,0.041366164,0.01291717,0.08465284,-0.105622426,0.017638572,-0.0054904614,-0.028629504,0.046977364,0.054402146,-0.030157246,-0.026031196,0.009078256,0.030921783,-0.004103768,-0.055580914,-0.07276151,0.0020939873,0.06051068,-0.07220811,-0.04412711,-0.02192733,0.12151356,-0.08892209,-0.02344812,0.08453392,0.11492102,-0.0066302978,-0.003480277,0.0006425971,-0.00065052195,0.06123894,-0.032043375,-0.038506873,-0.07305958,-0.03696027,0.065128304,-0.05832946,-0.02169768,0.0048538335,0.047202364,-0.023654208,0.03735108,-0.03209233,0.04735105,0.045829196,-0.03728452,0.0688832,0.029710798,-0.0077414718,-0.0769143,0.017220119,0.11888306,-2.796315e-08,0.09568512,-0.07518179,-0.0463755,-0.070243485,0.0084799435,-0.05769926,0.0067967637,-0.03666443,0.051335078,-0.024041174,-0.10607645,-0.037624385,-0.01348281,0.020309025,0.013687857,-0.012232786,-0.014582912,0.020742202,-0.011568852,-0.0017579575,-0.07907821,0.047069773,-0.14168094,-0.008047566,-0.00251899,-0.008635853,0.041094054,0.04709675,0.04087268,0.052782644,0.022203447,-0.00663788,-0.008577118,-0.08474299,-0.016673323,0.027255408,0.036416784,-0.063038036,6.860733e-05,0.034802325,-0.01890858,-0.015531505,-0.026862444,0.047848277,-0.11464826,-0.013424108,0.027755752,0.021461809,0.01750655,-0.015945962,0.082559794,0.059097093,-0.030997496,-0.037914347,-0.058090296,0.029087055,0.034477156,-0.04647659,-0.037828047,-0.04758584,0.046420503,-0.00019825606,0.14898497,-0.0061702468 +2.3.1.327,"The enzyme, characterized from an environmental DNA sample and expressed in Paraburkholderia graminis, catalyses the transfer of linear and branched long-chain acyl-[acp] molecules to L-phenylalanine, forming N-acyl-L-phenylalanine molecules.",384,0.9999999,-0.07561337,-0.09566799,-0.05816676,-0.017873386,0.033856053,0.073560864,-0.08042335,0.040462434,-0.0267912,-0.0065336325,0.14115843,-0.050038766,-0.07609337,0.0066816392,-0.06604884,0.14088751,-0.12548782,0.034222472,-0.03695079,-0.0476304,0.03785685,0.06984451,-0.0937285,0.015205567,0.026750576,-0.0254618,0.038918853,-0.07370181,0.012138663,-0.016810395,0.013349382,-0.043272134,-0.013408182,-0.03697803,0.054443076,0.066512994,-0.08076057,-0.0649091,0.116406985,0.0126715405,0.054973517,-0.05048849,-0.037809167,-0.025776053,-0.021677038,-0.028834619,-0.022588396,0.07081376,0.029588858,0.012551678,-0.010440337,-0.005584594,0.008166636,0.03186731,-0.12849362,-0.01076772,-0.05216828,-0.028501293,0.028443623,0.017563917,-0.004883517,0.02961093,-0.011211635,0.003869682,0.0049458127,-0.0645296,-0.01027827,-0.0071004885,0.074711226,-0.02438402,-0.06346859,-0.07092731,0.035006028,-0.028628075,0.030647514,-0.043315284,-0.029836781,-0.005575528,0.07049645,-0.013191136,0.08430402,-0.030136047,0.0344345,0.044836212,0.05182897,-0.024207143,0.038086355,0.07526942,0.047462605,-0.012493915,0.031583358,-0.06869543,0.022576485,-0.04582056,-0.060390145,0.04299209,0.010945143,-0.01799806,0.00454652,0.009527502,-0.030452447,0.002031894,-0.01588205,-0.121806,-0.11182279,-0.021215145,-0.0037014675,0.008672432,0.058476258,0.001341206,-0.025767736,-0.005187052,-0.009698049,-0.025555465,0.0052554975,0.05076041,-0.05930419,-0.057220306,0.01753211,-0.06470261,-0.022152323,-0.017628402,0.021937326,0.10559561,0.012173473,0.032779578,-0.07765605,7.728563e-34,0.08103342,0.025091838,0.0131263,0.006900536,0.0047452035,-0.05353208,-0.061649665,0.04861204,-0.026035069,-0.044711847,-0.03212298,-0.137928,-0.012716617,-0.003038318,-0.020996565,0.046862695,-0.030623743,0.014962232,0.04100953,0.027576396,-0.016538443,0.0351811,0.006106108,0.04999961,0.050692294,-0.011067202,-0.0067440844,-0.004068062,0.00083488435,-0.0031186207,0.020746555,-0.100028284,-0.09749868,0.041935336,0.03858667,0.036297288,-3.0350093e-05,-0.08351595,-0.011339175,0.072392665,-0.035820734,-0.013823116,0.05173994,-0.011232931,0.037857477,0.030827701,-0.030887602,0.0016842583,-0.05963993,0.06656156,-0.008298326,-0.007109074,0.04741683,0.008841609,-0.06199255,-0.019198008,-0.088208,-0.029583422,0.03566359,-0.0085091265,0.030186007,0.026686322,-0.03834443,-0.018956376,-0.0143897105,0.020867454,-0.03947915,0.005388808,0.06815689,0.031699505,-0.055997264,-0.055894595,0.0058968225,0.039429855,0.06930618,-0.047604088,-0.030030828,0.02009557,-0.021198126,0.050803,-0.043957967,-0.059561394,0.003004783,-0.030316215,-0.017052105,-0.055791494,-0.059792157,-0.06554064,0.07170136,-0.040550023,0.07441064,-0.025470048,-0.018301547,0.03347801,0.050528936,-1.5719203e-33,0.102751896,-0.15376008,0.02383431,-0.011170439,-0.05260067,-0.030812444,-0.015111353,0.056047387,0.047981456,0.002676793,0.028981056,0.024072418,0.023829527,-0.018218517,0.08697249,0.04930251,0.040033583,0.10202913,0.06288249,-0.0482058,-0.018629171,0.037181035,0.05447444,0.05643195,0.058272406,0.055198018,-0.028558854,0.076902926,0.105272315,0.06566338,-0.06432015,0.028561858,-0.00093480595,0.029051563,-0.0316103,0.04722085,-0.026940566,0.015165014,0.045642294,0.097908854,0.018947473,0.016253613,-0.014214772,0.01923912,0.015043492,0.025424266,-0.0143667,-0.020394852,0.022936882,-0.17965828,0.07191648,0.06270579,-0.0111179445,-0.073932536,-0.0051653306,0.11524773,-0.009826876,-0.0007488968,0.01126696,-0.055313203,-0.0056541837,-0.11638452,-0.0053116297,0.0019100189,-0.007090044,0.03669917,0.025814278,0.00951976,0.03343642,-0.06480391,0.008761659,0.04116492,0.049201157,0.13358359,-0.019560087,-0.083591945,-0.03128297,-0.08253,0.024249945,-0.07216338,0.03058857,-0.056822106,0.014948368,-0.023457186,0.044470854,0.019134272,0.03044075,0.06401942,-0.036868956,-0.0033089942,0.010845563,0.07524994,0.00045656753,0.10641166,0.08831398,-3.6278617e-08,0.09359666,-0.048856158,0.032977287,-0.059693117,-0.016193246,0.07210776,0.009952357,-0.010959719,0.008179447,-0.042077985,-0.06664473,0.116529204,-0.010680839,0.07345098,0.0053337663,-0.007941056,-0.050688997,0.0146604115,-0.040501047,0.024032326,-0.055246428,0.023717478,-0.085719116,0.040122826,-0.053676445,-0.01491767,0.06579156,0.0698281,0.05335734,-0.064267784,-0.00038565305,0.064210944,-0.036974333,-0.009729133,-0.019673103,0.019482844,-0.02575642,-0.09450171,-0.035204895,0.043802768,-0.0005257326,0.046722226,-0.0426345,-0.008330062,0.03078556,-0.05423699,0.0696248,-0.012063184,-0.013809736,-0.009125964,0.09095838,-0.030596899,0.004234731,-0.014738139,-0.028113605,-0.0659487,-0.049766988,-0.029385751,-0.012498437,-0.07425633,-0.017744713,0.05349999,0.15460777,-0.044730794 +2.3.1.328,"The enzyme, characterized from an environmental DNA sample and expressed in Paraburkholderia graminis, is a complex enzyme whose purpose is to divert branched-chain 2-oxo acids to production of branched-chain N-acyl amino acids by producing branched 3-oxoacyl-[acp] molecules. NasB accepts branched-chain 2-oxoacids such as 4-methyl-2-oxopentanoate, and catalyses a decarboxylative transfer to a thiamine diphosphate cofactor, followed by a transfer to a lipoyl cofactor, and finally a second decarboxylative transfer to the malonyl-[acp] acceptor. The products, such as 5-methyl-3-oxohexanoyl-[acp], can be extended by the fatty acid synthase system to form branched long-chain fatty-acyl-[acp] molecules, which serve as substrates for EC 2.3.1.327, long-chain acyl-[acp]:L-phenylalanine N-acyltransferase (NasA). During the reaction the lipoyl cofactor is reduced to dihydrolipoyl, which must be oxidized back to lipoyl by an unknown enzyme.",384,1.0,-0.07058667,-0.109673135,-0.054634526,-0.012672086,0.06339988,0.02221332,-0.08814626,0.031561818,0.016727587,-0.06308756,0.098492056,-0.09971372,-0.096994914,-0.025384104,-0.036185,0.0785159,-0.09408213,0.039677035,-0.034134142,-0.053449586,0.088925846,0.07984884,-0.052502308,-0.025871253,-0.058232583,0.01632828,0.043722562,-0.038623076,-0.0001384414,-0.11079062,0.022555614,-0.048471,-0.0018520135,-0.06494966,0.005400104,0.10472619,-0.07128245,-0.07682702,0.07477275,-0.016817989,0.110721916,-0.026372787,-0.015724497,-0.011174254,-0.020467745,-0.08263541,0.025645174,0.03181777,0.05584362,-0.00987864,-0.041411046,-0.010221748,-0.013519439,0.032292917,-0.10820171,-0.018157296,-0.034640323,-0.025484247,-0.047636446,0.0035560522,-0.0142809525,0.019194355,0.014818877,-0.034024786,0.03540706,-0.034189913,-0.027271502,-0.060433913,0.05888745,-0.032624565,-0.13032822,-0.06863649,0.030249666,0.032174822,-0.008443237,0.010390777,-0.0122754555,-0.025581257,0.09401538,-0.013989207,0.04464763,-0.0127765145,0.0073961387,0.022105727,0.04348554,-0.059383534,0.023288473,0.07152034,0.026331818,0.048875168,0.06351971,-0.039132543,0.031347904,-0.01741422,-0.0006923449,0.05514649,0.02583242,0.040197197,-0.0060193134,0.008182215,0.009127981,0.041808188,-0.032213274,-0.11875088,-0.09565984,-0.0027367852,-0.0041755983,0.020261336,0.047059093,0.026015818,-0.04998284,-0.029935488,-0.02226964,-0.01290083,-0.02195518,0.090083346,-0.03293848,-0.075097315,0.01566652,-0.085533306,-0.028962594,-0.020246103,0.062333655,0.015610381,-0.007841671,0.0316818,-0.1297732,3.7174686e-33,0.022669574,0.00022102479,-0.030235067,-0.012030906,-0.0130169345,-0.046802,-0.09368137,0.06282868,-0.022986626,-0.005914382,-0.02465118,-0.08268011,0.036989305,-0.012391045,-0.032863017,-0.043902032,-0.015246691,0.059324324,0.043347135,0.03600904,-0.002173015,0.053133156,-0.020567931,0.033517733,0.014192735,0.014993484,-0.018177902,-0.015203117,0.026806988,0.01027861,0.029329337,-0.068886034,-0.098975986,0.0031517253,0.07990775,0.006898293,0.010031552,-0.055271644,0.0068579926,0.045355882,0.03613027,-0.011541608,0.011279506,0.023370763,0.04188683,-0.0063213515,-0.054882474,0.045213766,0.00504821,0.06014582,0.0044980184,-0.053648435,0.061079282,-0.0008479436,-0.014263041,-0.022608984,-0.12502548,0.013796989,0.055751033,0.018603088,-0.031254392,0.057259753,-0.05943281,0.028717967,-0.06093758,0.045966152,-0.074790396,-0.039066076,0.045126732,0.061722286,-0.0022492944,-0.0076971552,0.027503526,0.09311105,0.07619042,-0.059795547,-0.03302892,0.04349862,0.0115980115,0.056400083,-0.012135347,-0.016851008,0.004294182,-0.025076764,-0.034968726,-0.0106915,-0.07222249,0.016369522,0.055375174,-0.0027578722,0.075790755,-0.008332693,-0.00768762,0.029202363,0.03664911,-4.4354094e-33,0.13597949,-0.14771302,0.0013148518,-0.08625977,-0.055015348,-0.0026597288,0.035334293,0.009964154,0.05535746,-0.0097869625,0.04744197,0.053370573,0.07759265,-0.048195533,0.06281511,0.01811965,-0.0031661927,0.105632216,0.034919795,-0.049234226,0.050335325,0.06900209,0.025026154,0.08502427,0.03039677,0.047848772,-0.04392099,0.071438,0.08201335,0.06437521,-0.051149018,0.028737469,-0.020250956,-0.0042281915,-0.05325021,0.014402183,-0.06764558,-0.0073316977,-0.020039337,0.10193799,0.01352012,0.04977545,-0.023697097,0.037421934,0.023518866,0.0120739145,-0.044646695,-0.013851364,0.04009044,-0.124237515,0.03680076,0.009909979,-0.03083959,-0.016661355,0.037480723,0.13076639,-0.003258035,-0.017978167,0.047334753,-0.0421153,-0.04764102,-0.09039605,0.026070945,-0.074591346,0.027888818,0.033155173,0.010519882,0.013201006,0.03093047,-0.00945769,0.016697148,0.04803057,0.03329567,0.056927335,0.020709412,-0.012134521,-0.04607722,-0.046385966,-0.008130846,-0.075473286,-0.010206039,-0.013516639,0.022201257,-0.055064615,0.027787741,-0.04294954,0.030374108,0.106672734,-0.038467716,0.037094105,-0.013114028,-0.006270034,-0.023572898,0.13958688,0.075249575,-5.8714996e-08,0.017879022,-0.025634173,0.06535636,0.010077608,-0.023547905,0.09617672,0.009276495,-0.0130264275,0.06435779,-0.07227205,-0.029283179,0.1300666,-0.01871429,0.10253503,0.0070598456,-0.0019454724,-0.036901027,0.046787936,-0.018587848,-0.014861717,-0.04644661,-0.027716557,-0.05881477,0.054696493,-0.013185034,-0.019949827,0.0642787,0.06928447,0.002474736,-0.07831533,-0.03069905,0.07023451,-0.005239733,-0.028287303,-0.045140352,-0.015136757,0.0043420764,-0.07210228,-0.0837489,0.11126369,0.020384746,-0.003070367,-0.07105045,-0.0034163657,0.07349655,-0.02685702,0.020747714,0.0294412,-0.036440566,-0.037129715,0.056475937,-0.007310895,-0.007495142,0.00788817,-0.023809236,-0.049437035,-0.077663444,-0.06279908,-0.013811142,-0.015904674,0.01094732,0.035563223,0.15943283,-0.0341434 +2.3.2.38,"The enzyme, characterized from the bacterium Streptomyces sioyaensis, catalyses the last step in the biosynthesis of the monoterpene alkaloid SB-203208.",384,0.99999994,-0.03509866,-0.050978873,-0.10967346,0.025063822,-0.063528605,0.09427351,-0.07569462,0.029240312,0.07756627,-0.045047496,-0.021295963,-0.027796457,-0.034937467,-0.04734364,-0.033673085,0.022148868,-0.07775356,-0.0064264443,0.039501958,-0.07146366,0.078441106,0.06816946,0.0007659114,-0.019911846,0.06726999,0.080295436,-0.02802057,-0.05167636,0.01578823,-0.060905017,0.0632908,0.007306063,0.08466556,-0.085824646,0.05928308,0.04006498,-0.08339786,-8.864587e-05,0.091315635,0.03417434,-0.0023942338,-0.06486815,0.022091515,0.04543639,-0.08229871,-0.04617942,-0.026300393,0.0533564,0.013231871,-0.032518536,-0.036624487,-0.08508574,-0.061834674,0.04563561,0.029908279,-0.03222739,0.048899412,0.011977097,-0.0022395204,0.031642184,0.1010625,0.032784566,0.034631222,0.008118716,-0.057450242,-0.018953681,0.029357893,-0.08548047,0.070120655,-0.035258327,-0.036142703,-0.018022075,-0.071096845,-0.020720314,-0.01212381,0.014147573,-0.0047584753,0.01737269,-0.04723982,-0.022098003,0.10891734,0.01000443,0.009079067,0.07553395,0.0090065785,0.008795726,-0.006338035,0.035368927,0.07813282,0.042396106,0.044742454,-0.009878861,-0.05219369,-0.05460824,-0.083612956,0.07042048,-0.029874912,0.029791385,-0.025502238,-0.0138503425,0.008923711,0.027845565,-0.065226436,0.0071944473,-0.002811681,0.013558905,-0.022355681,0.008616722,0.023531895,-0.057451207,0.058695067,-0.017063456,0.006637427,0.028626624,-0.0036276502,0.027869506,0.057662066,-0.045179803,-0.003910884,0.008075841,-0.0023427182,0.0058496976,0.0018057205,-0.0063680457,-0.046043787,0.027941374,-0.09153869,1.8260919e-33,0.062402565,0.07148434,-0.004587726,-0.057840567,0.03348905,-0.06965079,-0.034384463,0.037640553,-0.08556898,-0.015627887,-0.07915127,-0.06372449,0.0013863234,0.045815174,0.04799595,-0.023154097,-0.004976023,0.04287381,0.082504444,-0.09628234,0.018953623,-0.013175266,-0.085342914,-0.008864167,0.034308296,0.07930195,0.05065715,0.03701329,0.0549389,-0.01622971,-0.028459044,-0.07017613,-0.078181215,-0.03609357,0.045086063,-0.085831024,-6.155537e-05,-0.012776533,-0.05384192,0.037567955,0.002932601,0.102490306,-0.021427555,0.041617177,0.07146549,-0.038002837,-0.026135677,0.10540082,0.09068659,0.07666055,-0.0044716364,-0.031201163,0.0695177,0.09289927,-0.0770706,0.051260736,-0.0117797665,0.005921923,-0.031305667,0.04411767,0.039753575,0.036561288,-0.009838933,0.008565683,0.024582053,0.017720807,0.02671253,-0.040481534,0.016715374,0.101027474,-0.07870624,-0.04295616,0.026667923,-0.01718896,-0.026713572,0.0019454295,0.010915716,-0.028606711,0.060560238,0.00034810227,-0.014159196,0.033855304,-0.00614136,-0.03982773,-0.04531669,0.01591748,-0.006048294,-0.08517968,-0.022068826,0.07711107,-0.04931862,-0.029337335,-0.024562165,0.081908025,-0.056040768,-2.261797e-33,0.07863374,-0.0956883,0.06393858,-0.06252696,-0.06689673,0.036981948,-0.011039294,-0.0083015,0.004380785,-0.0018522508,0.06265946,0.005300753,0.06252509,-0.018725416,0.010034655,-0.08614513,0.037119217,0.117134094,-0.043651387,0.019145224,0.011606225,0.1197724,-0.0016664912,0.037618656,0.01576585,-0.04088339,0.08925496,0.056964915,-0.018899607,0.08266976,0.08548504,-0.055862125,-0.065911666,-0.018494803,-0.103970386,0.10461361,-0.0026919919,0.019715736,0.09698542,0.05635787,0.02630252,0.028352499,-0.0163615,0.08093928,0.08180774,-0.015892088,-0.11146011,0.06368161,0.04592798,-0.10830897,0.030405993,-0.0047054067,-0.017160408,0.031127097,-0.0052978676,0.0067310682,-0.0126401875,-0.0106270695,-0.023239095,-0.07181882,-0.036156207,-0.031734493,0.05419159,-0.02236488,0.048816975,0.03132218,0.017144859,0.021958463,0.09953958,-0.030141255,0.04959566,0.02701195,-0.08550465,0.10884716,0.011335943,-0.02868025,-0.08178787,-0.045978613,0.029493554,-0.0043762126,0.013288621,0.042004902,0.006290369,-0.0920953,-0.011176546,-0.09929591,0.060223017,0.074352846,0.026767064,0.038696937,-0.021042326,0.0049740197,-0.08209547,0.06881473,0.030676577,-2.8985214e-08,0.03510572,-0.009946527,0.015437829,0.03519011,-0.0039906744,0.008846291,-0.00091243215,-0.1088432,0.020764554,-0.033405982,-0.061260786,0.002264872,-0.00824915,0.05554465,0.030132988,0.0007946109,-0.019524375,-0.0069349306,-0.030222304,0.009848769,-0.009357554,0.0074116564,0.02901649,-0.051757157,-0.009137316,-0.12441735,0.009855694,0.024938235,0.023015942,0.03685964,0.020157358,0.020566586,-0.04946384,0.0022590177,-0.002833854,-0.0029866612,-0.039702643,-0.032240696,0.021889728,0.021802751,-0.006445143,-0.045941614,-0.07752085,0.025558833,-0.09528449,-0.00022951428,-0.07056363,0.017338678,-0.07229725,0.00017645385,0.08200177,-0.037519637,-0.04283434,0.0064789993,-0.122578196,0.013065808,-0.052378915,-0.029006273,-0.08558064,-0.072591074,0.06575249,-0.0025568542,0.16237344,-0.046142556 +2.3.2.39,"The enzyme, isolated from the bacterium Streptomyces sp. NCIMB40513, catalyses the N-aminoacyl transfer of L-isoleucine from a charged isoleucine tRNA onto the primary sulfonamide group of the monoterpene alkaloid altemicidin.",384,0.9999999,-0.03415879,-0.08089437,-0.14740427,-0.0035809788,-0.06853108,0.073323786,-0.02639734,0.00040600038,0.080763295,-0.038626507,0.056616064,-0.060361948,0.003693259,0.00010742332,-0.08001407,0.018078046,-0.06420595,-0.020682408,0.016780833,-0.080796756,0.013871472,0.063873336,-0.047409534,-0.047222797,0.116616525,0.040559072,-0.024776755,-0.08583397,-0.041231252,-0.07239131,0.07679585,-0.0816561,0.03841808,-0.06367741,0.046472576,0.055630192,-0.12223575,-0.015782151,0.07521987,0.05025746,-0.03435261,-0.0040676463,-0.013048975,-0.00507069,-0.105572075,-0.028909396,0.018137597,0.061721426,0.011349341,-0.034428116,-0.023842009,-0.09441723,-0.07601244,0.078914575,0.006381617,0.015701363,0.001134148,-0.025394728,0.0066689374,0.03453563,0.059638917,0.07760416,0.036297817,-0.05169503,0.006688945,-0.022463977,0.025759023,-0.048413668,0.07341752,-0.051627498,-0.047285255,-0.09552546,-0.075621374,-0.015148434,-0.00017593802,0.03308069,-0.02297902,-0.0031163795,-0.031251855,-0.049690858,0.04635022,0.02261112,-0.032750417,0.1077348,0.037712242,0.0015461047,0.030504264,0.036774326,0.09250309,0.012614103,0.054891177,-0.0027700786,-0.019517366,-0.030820541,-0.06378519,0.0024167928,-0.034549113,0.11859897,-0.05668901,0.016801516,0.032323953,0.057737622,-0.0859196,-0.04108458,-0.033818975,0.016808111,0.052101634,0.018019212,0.0037191445,-0.058320623,-0.012244828,0.021622349,0.00016794495,0.011098529,0.011177766,0.058716733,0.107881084,-0.020705188,-0.020537535,-0.0057874946,-0.057811286,0.008922106,0.029331235,0.009353135,0.0018823979,0.06432146,-0.06589863,4.2102174e-33,0.06387274,0.053229097,0.05216214,-0.003781902,0.019557584,-0.03911999,-0.059207276,0.041877326,0.0067015975,-0.043236483,-0.104391046,-0.048457455,0.013591861,0.029288042,-0.04642358,-0.0042980113,-0.0570415,0.022401838,0.07590087,-0.050479293,-0.034767944,0.020077419,-0.044954862,-0.0032884742,-0.005356209,0.028017333,0.014007086,0.035154015,0.06559022,-0.0010940324,-0.008108919,-0.0632859,-0.09297991,-0.03811124,0.05365565,-0.04309653,0.010188857,-0.005540849,-0.0218271,0.05172073,0.013344729,0.06716794,0.0073391357,0.016692257,0.057636406,0.012299864,-0.0918269,0.08742097,0.04229791,0.045686826,0.021412712,-0.083422005,0.10823147,0.0034793238,-0.040836554,0.06781781,-0.025774451,0.031759467,0.07177049,0.07369284,-0.0044595124,0.08488703,0.024513528,0.0038214864,0.04287741,0.04040931,-0.06306679,-0.034972828,0.05063122,0.027201336,-0.11114614,-0.011042717,0.052017886,0.026703957,0.022644443,-0.030049954,-0.062073596,-0.04832485,0.048368,-0.009470927,-0.026888048,-0.058087762,-0.00031907874,-0.06364204,-0.027924428,-0.04672468,-0.0018914068,-0.09927944,-0.045667805,0.086708486,-0.051582202,0.015478541,-0.09584624,0.018240787,0.03221587,-4.208544e-33,0.12856609,-0.1199595,0.038707696,-0.07998249,-0.093313105,0.054603387,-0.049796145,-0.041524574,-0.01677913,0.05006119,0.07531054,0.033572137,0.06702666,-0.0124745155,0.038861852,-0.09358846,0.058244895,0.037494063,-0.017718602,0.022155732,-0.037074644,0.058061123,-0.036234386,0.03324621,0.03970569,-0.0061794887,0.045390505,0.08346303,0.048577316,0.02233731,0.050208714,-0.019148938,-0.020760084,-0.037244745,-0.062072556,0.09771935,0.010137658,0.038791705,0.037924465,-0.009566593,-0.01037086,0.01916208,0.02046304,0.081383236,0.040240165,-0.011512522,-0.0838859,-0.031281937,-0.033933476,-0.06018385,0.09506955,-0.037679326,0.0029169933,-0.017855352,0.036409184,0.06931357,-0.01570934,-0.023932513,0.025266958,-0.05777571,-0.022880152,-0.007470421,0.002809408,-0.072897136,0.037033446,-0.005733034,0.0002522155,0.031456005,0.06299135,-0.04447159,0.021324532,-0.02495613,0.032001894,0.035751745,-0.043596994,0.008550176,-0.008816912,0.00016528192,-0.0074076923,-0.059212208,0.0048673535,-0.06498973,0.050444633,-0.13019523,0.0035278203,-0.08441528,0.058329638,0.10374116,0.03291441,0.051579315,-0.036100913,0.017088179,-0.02606094,0.048902,0.08385078,-3.3488508e-08,0.03974827,0.028868893,0.038188074,0.08546009,0.007266481,0.06004183,-0.03465589,-0.091332845,-0.01528375,-0.0006260429,-0.01077126,0.04072932,-0.0068125273,0.078046516,-0.0014068544,0.079428025,-0.052390695,-0.015704656,0.007735347,0.025747133,-0.038502116,0.03403227,-0.034446128,-0.03327205,0.035618648,-0.10634739,0.059765425,0.041511,0.00970826,-0.038866747,0.051796097,-0.0040700175,0.0037890577,-0.017066853,0.0030934475,0.033091698,-0.048231225,-0.044607803,0.043711845,0.033836626,-0.00010133819,0.006317477,-0.10674421,-0.00092106254,-0.087963685,0.0411124,-0.023355404,0.04447928,-0.10836772,0.08005973,0.08321849,-0.037434254,-0.0045720264,-0.008682727,-0.073007464,0.05211198,-0.033450652,-0.043155316,-0.034252923,-0.052817047,0.0042172736,-0.020967148,0.10750526,-0.00168424 +2.5.1.161,"The enzyme, isolated from the bacterium Streptomyces sp. NCIMB40513, participates in the biosynthesis of the monoterpene alkaloids altemicidin, SB-203207 and SB-203208.The enzyme catalyses a pyridoxal phosphate-dependent [3+2]-annulation reaction between S-adenosyl-L-methionine (SAM) and NAD+. It transfers an aminocarboxypropyl group that combines with the pyridinium moiety of NAD+ to create a pentacyclic ring, forming a 6-azatetrahydroindane scaffold.",384,1.0,-0.036482655,-0.06498271,-0.14293993,-0.012958281,-0.052323066,0.10010787,-0.063516654,0.0059978063,0.12722228,0.045860983,-0.029593023,0.010628853,0.023931103,0.028422926,-0.050282747,0.013598875,-0.09899315,-0.022510964,0.08790923,-0.01137768,0.072473586,0.07677895,0.015905853,-0.024590125,0.11042541,0.09015674,-0.016264316,-0.026050126,-0.05677511,-0.023497585,0.041209128,-0.026014976,0.02631765,-0.10740516,0.08583044,0.06955578,-0.11209511,0.05735267,0.064118825,0.041387748,-0.0008613598,-0.022685656,0.008506726,0.026865005,-0.1026645,-0.010474039,0.0038384802,0.04436417,0.007114374,-0.034689814,-0.04334449,-0.08470541,-0.04582133,-0.001933241,0.085533716,-0.012693304,0.026421253,-0.034449585,-0.036902234,-0.0141635835,0.112051174,-0.043955453,0.04359166,-0.0070628324,-0.0069646826,-0.055027604,0.030616822,-0.065300584,0.07293441,-0.06391942,-0.09579011,-0.024423374,-0.002378898,-0.016018568,-0.012181008,0.06931179,-0.010743,-0.016057044,-0.044013448,-0.03803888,0.07253975,0.014688227,-0.0048962035,0.08248302,0.08287198,0.032892764,0.032176115,0.02254778,0.062338036,0.015874032,0.011277899,0.019332089,-0.031194778,-0.040332362,-0.10213949,-0.0061971787,-0.040732715,0.04489077,-0.10171275,-0.0124137765,0.04580823,0.077197775,-0.05346707,-0.04553641,0.0033556712,0.030686997,-0.04551348,0.02529885,-0.058255937,-0.021276765,0.025362259,0.031015273,0.004056443,-0.01436197,-0.009507122,0.06462283,0.0498768,-0.029407714,-0.029171411,0.016183568,-0.04615766,-0.013854541,0.0027286364,-0.006023976,-0.021405084,0.044398613,-0.08498244,4.7032918e-33,0.06255156,0.11221026,0.0031143029,0.0046249917,0.054365102,-0.04280553,-0.056533016,0.024279693,-0.04566008,-0.03866732,-0.06642358,-0.05225472,0.054080434,0.016734008,-0.0190542,0.009999666,-0.058704685,0.012668251,0.055459946,-0.051348083,-0.005896759,0.02744135,-0.073799394,0.050164744,0.026636051,0.041444585,-0.0059325374,0.028251613,0.061997503,-0.005271871,0.018316567,-0.031075202,-0.113854885,-0.05381931,0.06812774,-0.07974408,-0.041721657,-0.034501545,-0.022367334,0.06408911,-0.039583303,0.04825214,-0.01677735,0.042384367,0.038106404,-0.039455928,-0.021227408,0.1189552,0.052128047,0.06429712,0.01209003,-0.041721564,0.12283498,0.070030354,-0.11997978,0.023565315,-0.03558998,-0.050496455,0.023904901,0.075836755,0.023999391,-0.010082525,-0.011189426,-0.008448153,0.027787108,0.012308252,-0.04637174,-0.056646533,0.024508221,0.08537593,0.0050179698,0.016592436,0.06759031,0.066392,-0.0089823725,-0.015760286,-0.033634726,-0.025141848,0.037708532,0.024816798,0.0102911815,-0.016975848,-0.041427694,-0.060362417,-0.025295679,-0.029891422,-0.006997207,-0.10336966,-0.01989112,0.037071705,-0.020220483,-0.074920245,-0.039637275,0.026652755,-0.022977255,-4.4192045e-33,0.11891897,-0.07015572,0.05584579,-0.06418705,-0.06226985,0.062029216,-0.006023382,-0.059997603,-0.03384865,-0.023394989,0.06643254,0.020250384,0.07519129,-0.03154642,0.00022812195,-0.13965301,0.04001151,0.067839645,0.0063711843,0.004469121,0.019208388,0.10213625,-0.032377295,0.027327277,0.03515185,-0.023657948,0.021125518,0.035161514,0.0059420466,0.06742392,0.06405436,-0.018104274,-0.09018697,-0.031364176,-0.09539529,0.09742607,-0.047621805,0.004021377,0.036029197,0.047598045,0.03241871,0.042150944,-0.019148866,0.066444024,0.09330212,0.002311165,-0.12336689,0.037463028,0.03604246,-0.13760707,0.04829299,-0.008662348,-0.00986775,-0.010604595,0.047022615,0.033259735,-0.0022581932,-0.038740393,0.018908266,-0.02770862,-0.027266813,-0.02897931,0.03136449,-0.015874226,0.038609017,0.008802915,0.029410776,0.03915156,0.08405126,-0.02135705,0.0058279173,0.031671163,0.0003833957,0.0772357,-0.03103692,0.012474129,-0.049011342,0.009088824,0.004854397,-0.018810458,0.04118182,-0.04739123,0.06792163,-0.06286799,-0.022134777,-0.042281702,0.08118129,0.0561414,0.0005616553,0.021696795,-0.044305224,0.050287526,-0.014603001,0.09295962,0.026787078,-4.4050697e-08,0.07949199,-0.007893438,0.059914183,0.019508319,-0.0053427173,0.0065316185,0.0097828945,-0.10796108,0.019885413,-0.033432048,-0.022870833,0.009437387,0.02258867,0.050283868,0.016501335,0.07023493,-0.028403217,0.018148055,-0.019180013,-0.026668655,-0.0797756,0.0041921,-0.05571493,-0.017916959,0.027213793,-0.058310088,0.04098716,0.040270712,0.0019795913,-0.013726621,0.052007657,-0.049012706,-0.010970016,0.022286635,-0.048209216,-0.026951281,-0.0845678,-0.0032892623,0.012462981,0.016323688,0.01444894,-0.070465446,-0.07289336,0.043828852,-0.06744538,0.044540726,-0.060455907,-0.009493212,-0.124855466,0.020342803,0.07624002,0.009860046,-0.020276126,0.006602007,-0.09693672,0.037082143,-0.020550862,-0.044959776,-0.046970215,-0.07558015,-0.019509394,-0.0044850614,0.10211552,-0.03544626 +3.1.1.123,"The enzyme, characterized from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine. The enzyme catalyses the hydrolysis of a methyl ester, which is followed by the spontaneous decarboxylation of the resulting carboxyl group.",384,0.99999994,0.02153237,0.026835442,-0.13210243,-0.021951146,0.007657338,0.049147096,-0.08026833,0.007758675,0.0929552,-0.023537168,-0.0032579391,-0.024022484,-0.11902952,-0.026161375,-0.06563329,0.023960322,-0.12515451,0.0064356797,-0.0049872664,-0.0845783,0.09902024,0.09118484,-0.052790985,0.018555883,0.015474255,0.0020769837,0.01988203,-0.02785457,0.05571574,-0.07882444,0.073217735,0.006213409,0.087471746,-0.04108759,0.0464441,0.07622816,-0.031743117,-0.11199597,0.056227554,0.037275936,0.017853625,0.0053561055,-0.057502355,0.022481384,-0.1021457,-0.036661472,0.030246183,0.05294079,-0.050821804,-0.018421002,0.004559017,-0.053605504,-0.06363824,0.026411932,-0.018418944,0.08007668,-0.029125104,-0.03522015,-0.024052763,0.011919323,0.059374955,0.07272268,-0.025220638,0.012165773,0.0104165,-0.028351495,0.026142118,-0.0068216114,0.062144484,-0.06261548,-0.03461041,-0.073780775,-0.031218603,-0.0074685984,-0.030202348,-0.00248231,0.01271681,-0.015959261,0.04323489,0.023098199,0.06831428,0.013703932,0.02043711,0.044376116,0.06310141,0.036171507,-0.06543381,0.076833226,0.069675826,0.04347511,-0.00070065615,-0.061685048,-0.009559891,-0.012433817,-0.032341335,-0.0034356285,0.008611643,-0.042720467,0.03733365,-0.0067191413,0.002321762,0.016350092,0.0045503313,-0.06530546,-0.04198114,0.031004403,-0.029926205,0.04131055,0.045593563,0.041761313,-0.05904712,0.039299127,0.024701469,0.0065316786,-0.03232979,0.05860786,0.02123693,-0.059480466,-0.02825901,-0.061205357,0.054072574,-0.024452507,-0.03344639,0.040553875,0.026866233,0.045166478,-0.14178991,1.5628389e-34,0.03237623,0.046938322,0.024856584,-0.017303169,0.040539145,-0.02781821,-0.035973866,0.024047965,-0.05298496,0.005372605,-0.09846104,-0.09404425,0.014348637,-0.01043113,0.042258035,-0.05170029,-0.03629528,0.026558943,0.013866829,-0.008566611,-0.020370768,0.113232724,-0.10307437,0.0316363,0.016698558,0.050591666,-0.050028138,-0.005293728,0.060589846,-0.026620634,-0.0056255143,-0.07715838,-0.052512277,0.010004181,0.10599454,0.01246136,-0.028222255,-0.052641433,0.028874768,0.06541584,0.010736077,0.015213136,-0.0083240345,-0.022682888,0.0073685795,-0.0612351,-0.06511145,0.039000053,0.043348543,-0.013727494,0.0012862452,0.030131586,0.08495043,0.05033077,-0.040321317,0.031102257,-0.026166448,-0.0448536,0.024317766,0.03731018,-0.013775579,-0.02870078,0.0029047432,0.013699056,0.041138265,-0.025439112,-0.09960425,-0.054786094,-0.01196754,0.09020432,-0.10445127,0.00043723744,0.0102013005,-0.07622722,0.024537403,0.010718111,-0.062323842,0.031372692,0.031820387,0.0128049115,0.006363948,0.002186598,-0.008563319,-0.056377795,-0.031874526,-0.009964634,-0.008605517,-0.06546842,-0.0035133057,0.09289359,-0.014821047,-0.072546944,-0.069130555,0.023699105,0.08836065,-2.6312745e-33,0.030335171,-0.10391111,0.025443556,-0.029654954,0.016727721,0.07138396,-0.033414077,-0.08226963,-0.04419483,-0.07426119,0.0005579928,0.02575001,-0.0143109085,-0.010054844,0.018539742,0.008295055,0.06835953,0.13895778,-0.004913424,-0.01908278,0.0060022254,0.10450739,-0.018938327,0.011170967,0.014164436,-0.070037715,0.04978856,0.06330494,0.080289885,0.06316883,0.057430543,-0.024261396,-0.026968028,-0.020674499,-0.03866767,0.11448945,-0.025686419,0.03752135,0.054494873,0.015837578,0.026446495,-0.022615366,0.016028827,0.06018077,0.04215445,0.06438184,-0.09078619,0.013776858,-0.019034173,-0.051888153,0.080295786,0.01835095,0.01139213,0.06048149,0.03835018,0.037623286,0.022964284,-0.08146104,0.0008750951,-0.030498406,-0.027735498,-0.0128368,-0.0477086,-0.042838894,0.028143987,-0.08883737,-0.044329472,0.049398422,0.105100214,-0.06764932,0.07129394,0.07953138,-0.05730261,0.11857658,-0.028430546,-0.052693814,-0.11559987,-0.06653118,0.0120892245,-0.060777828,-0.0718154,-0.006175964,0.067034476,-0.08028933,-0.010395094,-0.090233095,0.07301855,0.09039801,0.004653803,0.039004676,-0.020331474,-0.012516339,-0.06313129,0.080371566,0.01426596,-3.4319527e-08,-0.050120108,-0.07079371,-0.027805036,-0.06580158,-0.041039098,0.05363917,0.0692734,0.029096574,0.038256213,-0.024936378,-0.0071523446,-0.008322691,0.01951744,-0.016781848,0.04967766,0.05702523,-0.0649624,0.0309629,-0.0022183591,0.018156743,-0.0012283647,0.04570433,-0.06230123,0.06528177,-0.027491681,-0.02622141,0.015995227,0.10378304,0.0016310494,0.050074786,0.020702574,0.07880823,0.045640375,-0.028855093,-0.07895683,0.022407778,0.014656331,-0.022170985,0.027538959,-0.009212045,0.038686395,-0.031645473,-0.08748928,0.019746045,-0.07273938,0.0067374557,0.012784031,0.024566479,0.013227966,0.00014317321,0.06945553,0.021057665,-0.056333866,0.016833924,-0.04596574,-0.059594247,-0.037595406,-0.047482956,0.021940097,-0.055979364,0.037176214,0.0093278475,0.19105656,-0.0687877 +3.2.1.227,"The enzyme, characterized from several bacterial species, hydrolyses the terminal N-acetyllactosamine residue (beta-D-Gal-(1->4)-D-GlcNAc) from the non-reducing end of oligosaccharides with the structure beta-D-Gal (1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->R). The enzyme also catalyses the activity of EC 3.2.1.140, lacto-N-biosidase, and is not active on oligosaccharides with a terminal GlcNAc residue.",384,1.0,-0.0047995327,-0.09630904,-0.07485487,-0.029541286,0.074738204,0.022731587,-0.049642634,0.041251928,0.09518249,0.040198904,0.019081974,-0.004678248,-0.05317494,0.006444445,-0.04736949,-0.0383225,-0.03254339,-0.012464772,0.024742775,-0.025186226,0.12022329,0.024551885,-0.030773807,0.03480302,0.05236674,-0.029398737,0.058739398,-0.05200476,-0.025593095,-0.07511494,0.015618582,-0.10136884,0.08100799,-0.023370909,0.026158562,0.051956028,0.029822355,-0.043854117,0.044498906,0.0020087138,-0.005409012,0.01819682,0.038593505,-0.025915705,-0.0100572705,-0.030747969,-0.007149018,0.030484602,0.0661949,-0.0697448,0.0011061995,-0.097288445,-0.0619308,0.05794912,0.10364521,0.01837524,-0.030554263,-0.06784469,0.032856505,0.1101097,0.08345907,0.08701842,0.01077912,-0.018525632,-0.04439608,-0.07606714,0.07362868,-0.09444126,-0.03960599,0.043537922,-0.068276875,-0.02298332,0.0077581936,-0.011492103,0.06353986,0.056660093,-0.03219303,-0.06321917,0.029036941,0.022189097,-0.010195024,-0.037727576,-0.014558204,0.05984681,-0.04144475,-0.066196896,0.013441918,-0.024016863,0.1253947,0.025027776,-0.026181277,-0.04386823,0.027320573,-0.016180947,-0.091268964,-0.059677303,0.02683895,0.054635882,0.06358485,-0.03190489,-0.020456953,0.039960917,0.013981514,-0.08960569,-0.052504115,0.08944524,0.07180039,0.08177311,0.05641385,0.04448708,-0.03543895,-0.0032368707,-0.014910094,0.019252047,-0.16102754,0.122878626,0.02672982,-0.13398777,-0.08592537,0.011584994,0.03621873,-0.022108627,0.0989462,0.013748408,-0.0168738,0.07626716,-0.0035554012,-1.8598e-33,0.040006734,0.014695144,0.0706869,-0.040832687,0.050050244,-0.012886534,-0.09454947,-0.04401839,0.005084314,-0.0009753985,-0.035423752,-0.003395311,0.00049252337,0.07047458,0.039264522,0.07280746,0.013249299,-0.042939685,0.009400983,0.037311148,0.005065134,0.0025409558,-0.048176374,-0.00086274015,0.08194595,-0.006628148,-0.019301642,0.05283209,0.08250918,0.01900413,0.048735455,-0.088773176,-0.11171444,0.04957223,0.062288683,0.016091567,-0.029265521,-0.018392049,0.03586472,0.0003357618,0.023826431,0.054988,0.018427646,-0.0068768198,-0.029718317,-0.0017766225,0.014929953,0.028616467,0.01460666,0.097080536,0.034007233,-0.03773861,0.011033216,0.045348633,-0.0050774226,0.05697409,-0.069340765,-0.027363628,0.068759695,0.03256213,0.016747454,-0.005663335,0.0003994904,-0.03779228,0.04056608,0.035445847,-0.038741123,0.026282739,-0.0072422135,-0.039350696,-0.088923685,-0.07433364,-0.00796622,0.018491598,0.0008540848,-0.05717263,-0.048010673,-0.0067025693,0.011109377,-0.016667532,0.021340432,0.00941906,0.008087508,-0.030216917,-0.036130738,0.04609499,-0.046827912,-0.005759361,-0.039139345,0.00670977,0.03680476,-0.036762614,-0.062276594,0.060340505,-0.024315761,-6.394707e-34,0.11302961,-0.10804594,0.06008008,-0.051641885,-0.015953138,-0.022562247,0.041460965,-0.008269862,0.011796861,-0.07646575,0.044360396,-0.04220832,-0.018642083,-0.0031479353,0.0026906396,-0.04040261,-0.031033516,0.07714851,-0.03325694,0.031862266,-0.017323129,0.023283804,0.01098927,-0.051649448,0.04210825,0.00089687156,-0.012820763,0.021824991,-0.0005167259,0.04874237,0.021834696,0.009542328,-0.046017338,-0.059460334,-0.07383771,0.016283106,-0.024991758,-0.06442935,0.033483032,-0.0018510177,0.030110428,0.051878937,0.0040606265,-0.050698385,0.03088494,0.100978345,-0.04251349,0.051060185,0.010862254,-0.06642302,0.034605958,-0.010718564,0.039448556,0.04696794,0.052283946,0.06646146,0.07097094,0.08448026,0.052282866,-0.06289458,0.010112891,0.011758639,0.002524649,-0.07965337,0.041117232,0.010591611,-0.04293908,0.047989212,0.05253451,-0.025310555,-0.026837474,0.030011134,-0.026757315,0.016815307,-0.033975545,0.00011201826,-0.13758832,-0.08936238,-0.031407546,-0.03810445,0.025112739,0.0030933241,0.012182326,-0.03417333,-0.015896667,-0.03983227,0.051100194,0.12011955,-0.047039803,0.07542734,-0.05568884,-0.04402849,-0.007539029,0.09985385,0.09087847,-4.2355154e-08,-0.0043620924,-0.025396718,-0.04391639,-0.08082886,-0.044838052,0.0031186226,-0.05438921,0.0041851066,0.08045642,-0.027495598,0.023559893,0.10843718,-0.015646962,0.021268787,-0.03994844,0.0036329876,-0.004716989,-0.012916717,0.0031028884,0.07125006,-0.08461646,-0.0060353656,-0.13569859,-0.015994271,0.0056753242,-0.07479265,0.06286358,0.100189544,-0.10459062,-0.057034254,-0.018065091,0.06478322,-0.016066438,-0.06321405,-0.020789595,-0.017343754,-0.07562705,-0.036030162,0.03139979,0.018309526,0.0839968,-0.02328441,-0.059444055,-0.028075432,-0.0031214433,0.04132329,0.006249688,0.07843635,-0.07048488,0.033582103,0.03210669,-0.043766297,-0.053635456,-0.047499135,-0.0471242,-0.042648252,-0.024743525,-0.042990427,-0.049241602,-0.041950952,0.024939308,-0.0770574,0.12261107,-0.025113618 +3.2.1.228,"The enzyme is an endo hydrolase that hydrolyses the alpha-(1->3) bond in funoran, a polysaccharide produced by red algae of the genus Gloiopeltis. The cleavage point is different from funoran endo-beta-hydrolase (EC 3.2.1.222). The enzyme from the marine bacterium Aquimarina sp. AD1 also cleaves the alpha-(1->3) glycosidic bond between 3,6-anhydro-alpha-L-galactopyranose and beta-D-galactopyranose of agarose (cf. EC 3.2.1.158, alpha-agarase). The anomeric configuration of the product (configuration retaining or inverting) has not yet been determined.",384,1.0,-0.046038143,-0.10795122,-0.09878999,0.009633163,0.0057332306,-0.012023802,0.031890687,0.011124822,0.029771596,-0.0040113074,0.011955841,-0.027800106,-0.12045333,0.051085535,-0.0908677,0.044757713,-0.04748301,-0.05319197,-0.017261812,0.023461478,0.118422136,0.005197123,-0.09801982,0.025162783,0.062839635,-0.02817327,-0.017707838,-0.05975737,-0.07591934,-0.0673633,-0.040073786,-0.068405874,0.1579137,-0.025464734,0.09150305,0.059044294,-0.04698975,-0.07855298,0.0034368827,-0.01199629,0.0509411,-0.0012397302,0.05810823,-0.022850232,-0.0680216,0.03423788,-0.0036188893,0.022892162,0.04170819,0.023573138,-0.047865383,-0.1035155,-0.12719116,-0.008173372,0.035405323,0.020848215,0.0024158182,-0.049311005,-0.056240834,0.023646746,0.06029246,0.017158069,-0.051691465,0.053103555,-0.039316807,-0.051620223,0.08349891,-0.09575734,-0.063285045,-0.0101721175,-0.06454055,-0.06037387,-0.031109313,0.0033916135,0.04499611,0.05410195,-0.031613573,0.003620815,0.048982747,0.0005284128,0.04548919,0.020229325,0.02669638,0.07423503,-0.022991886,-0.06405647,0.010090884,0.020651089,0.0846381,-0.0045334464,-0.011048909,0.0070292554,-0.03953728,-0.058282807,-0.010517499,0.053137284,0.005335889,-0.053011607,0.006451026,-0.009018322,-0.023577446,-0.0025602677,0.029860104,-0.10323972,-0.044730477,0.095455855,-0.034716014,0.08572073,0.08763627,0.050206944,-0.04994912,0.007860749,0.05489389,-0.0422607,-0.047478594,0.089023136,-0.016604906,-0.04125258,-0.027551584,-0.0051111807,0.042655673,-0.070639275,0.08601056,0.089000314,0.036434498,0.027667437,-0.10664083,1.04171685e-33,0.06614709,-0.023916444,0.023159994,-0.004007108,0.030255796,-0.009694278,-0.053014327,-0.0470506,-0.05096393,0.010341213,-0.05946673,-0.009126659,0.016410364,0.039441325,-0.004100754,0.07139165,0.03517402,-0.005799138,-0.0030712907,0.06326064,0.009875686,0.038793016,-0.016060743,-0.044042632,0.047287226,0.0280363,-0.016664494,-0.022189029,0.054024678,0.014951082,0.052534565,-0.056002814,-0.1392461,0.056551468,0.039749224,0.0037417149,-0.053283285,-0.06492982,-0.023542162,0.04255806,0.01188984,0.051923003,0.0021123243,0.0027551737,0.08798527,-0.06404979,0.01003467,0.041820616,0.062599175,0.092812,0.0062662256,-0.046192255,0.055519894,0.0611935,-0.064287886,0.06484826,-0.04718392,0.07050161,-0.0018381382,0.041632812,-0.009968926,0.050693598,0.003234177,-0.039324652,-0.05992083,0.072664954,-0.014000815,0.019476885,0.041924722,0.04381188,-0.05764259,-0.020756373,0.0066852774,0.024919733,-0.05228749,-0.07551093,0.03031614,-0.006712208,0.023041712,-0.013001425,-0.00063031225,0.006455703,0.07767491,0.03382944,-0.1289199,-0.005901665,0.030723043,0.02164023,-0.012200594,0.047492847,0.03569268,-0.037857305,-0.06700925,0.03569703,0.023384089,-1.8954791e-33,0.13947134,-0.13909198,-0.0014894386,-0.07522452,-0.020330945,-0.006715969,0.041167658,0.020704677,0.0028946395,-0.03436183,0.053722717,0.050249945,-0.0044361143,-0.0668194,-0.004696188,-0.03376201,0.05010748,0.079854816,-0.0036386463,0.004183842,-0.018608924,0.056010056,0.073302954,-0.042409763,0.04708539,-0.038400803,-0.0054156138,0.07228931,-0.028121317,0.024788363,-0.021284983,0.041509684,0.0069764676,-0.07970452,-0.0429672,0.036655318,-0.08244626,-0.024305506,0.057084862,0.04774372,0.047073796,0.035067875,0.06719653,-0.0089817,0.07696895,0.08895892,-0.07149854,0.041786112,-0.0077301827,-0.06873639,-0.0063048564,-0.022049578,0.026509706,0.043832228,0.027937794,0.015473535,0.06885278,0.061609957,-0.053862285,-0.020650715,-0.012476334,0.006767894,0.06645029,-0.046983358,0.056191657,0.08825944,-0.03441731,0.04329438,-0.023937488,0.059896972,0.030264879,-0.028059803,-0.07790701,0.073986165,0.012419297,-0.032400887,-0.100386806,-0.05921965,0.023077551,-0.021687353,0.014229349,0.051896043,0.005162992,0.010210104,0.004200511,-0.07255416,0.090481654,0.10480672,-0.037270132,0.025540248,-0.039132994,-0.0025650896,-0.029441325,0.045789756,0.091307245,-4.2621373e-08,0.0108183585,0.0025252507,0.0065976637,-0.0623114,-0.020152073,0.03464664,0.023103086,0.024549302,0.017737215,-0.10240257,-0.007944048,0.06336207,0.011997271,0.007793763,0.010985512,-0.006415702,-0.01617222,-0.055203225,-0.045774765,0.03531625,-0.064729586,0.004646433,-0.1327935,-0.05993581,-0.07821601,-0.024799215,0.036397018,0.051470004,-0.029459244,-0.019368561,-0.0028022558,0.03969242,-0.014722425,-0.020561071,-0.044181168,0.041048445,-0.051317465,-0.050119266,0.010918083,0.041499548,0.038891003,-0.038842186,0.03131558,-0.027782049,-0.023772424,0.063710496,0.011116957,-0.017358461,0.0045093773,0.044801045,0.08601086,-0.024940085,-0.107414246,-0.067513205,-0.06461962,-0.09643329,0.014211959,-0.030749148,-0.034642134,0.016475573,0.008930696,-0.024164231,0.12433365,-0.0063987304 +4.1.1.130,"Requires Zn2+. The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency.",384,0.99999994,-0.034881607,0.046534184,-0.022021988,0.0092896875,0.017828314,-0.004294101,-0.062471744,0.040082615,0.015853161,-0.06898721,0.059467796,-0.033456355,-0.06424082,0.027813168,-0.05125028,0.017173128,-0.06516389,-0.00025630678,-0.009521845,-0.032763425,0.09142683,0.0065125693,0.026849065,0.010296997,0.008865049,-0.072746515,0.021709617,0.028440742,0.046071377,-0.025789648,0.0029291853,-0.057985306,0.060584795,-0.07103812,-0.008700047,0.048772648,-0.016108459,-0.040513337,0.03236932,0.012644057,0.124386095,-0.03845018,-0.014281233,0.09492259,0.008091397,0.05665195,-0.015087786,0.05801519,0.02670386,0.05741833,-0.050825365,-0.044269536,0.0180179,0.055984113,0.03371764,0.07224715,-0.08546497,0.045493882,-0.0038860228,-0.04252696,0.07196042,0.028798604,-0.008535682,-0.031768292,0.062100362,-0.0021760347,-0.017627265,-0.05179894,-0.0056625544,0.027760277,0.008247289,-0.01590887,-0.11169217,0.05162805,-0.08765795,0.031658895,-0.016523652,-0.0506389,-0.057738084,-0.051516023,-0.0067026494,-0.00011818033,0.09666123,0.059632137,0.050497867,0.046265688,0.05355012,-0.005434451,-0.030787168,0.051025603,0.02959529,-0.027975349,0.010667646,-0.02376863,-0.010733797,0.05229968,0.07338644,0.09028756,0.010338274,-0.005855864,0.05523119,0.008138794,0.0148140015,-0.09242459,-0.05422126,0.04521612,-0.002037592,0.003519785,0.021900328,0.05740424,-0.02750622,-0.019994363,0.011805507,-0.019941343,0.00799604,-0.013933784,0.00029086426,-0.014731736,-0.06433859,0.010788926,-0.050688874,0.048619635,0.0021140426,0.081489556,-0.012863349,0.017287346,-0.15943971,1.5993602e-33,0.009634319,0.036802556,-0.018351942,-0.01914084,-0.06557278,0.04205,-0.027354069,0.007685973,-0.11010215,-0.040659618,-0.114652894,-0.050580245,0.03449578,0.03592195,0.026971204,-0.03609678,0.06990616,-0.048810996,0.094138026,0.0048239874,-0.02491929,-0.051887516,-0.052209113,-0.08212343,-0.017398883,0.030189225,-0.027338479,-0.02368945,-0.024607277,-0.0024457606,-0.016159695,-0.11999188,-0.10024833,0.02794741,0.089288205,-0.061938085,-0.023520488,-0.05617468,-0.031122243,-0.017770622,0.04784246,0.043097578,-0.005241319,0.005771929,0.09578957,-0.028743066,-0.011727858,0.121293955,0.03501046,-0.00011958577,0.0279855,0.0575934,0.05110521,-0.0202926,-0.089433484,0.021634938,0.018312125,0.020406365,-0.008316009,0.051602617,-0.03780159,0.07303599,-0.013296591,0.058181126,0.008962157,0.10003925,-0.07624545,-0.018972171,-0.0019334756,0.036989443,-0.041548964,-0.0891977,0.013756268,0.062437307,0.017402481,-0.056637272,-0.05233787,-0.04313346,0.11311293,-0.010467677,-0.09420152,-0.040425263,-0.01786747,-0.05273675,-0.01741795,-0.020983882,0.016776247,-0.05890583,-0.029299304,0.059396405,0.06681879,-0.083683215,-0.043052904,0.054999076,0.047862597,-3.28841e-33,0.037164103,-0.056491476,0.051332284,-0.073136866,-0.0015187153,0.061028004,-0.03926717,-0.05510184,-0.022666875,-0.01198066,0.124334835,-0.030583305,0.020600835,0.0039775246,0.026429627,0.045146547,-0.020191146,0.10001005,0.09635021,-0.06780082,0.05120426,0.026047159,-0.00601868,0.03760285,0.0047346954,0.039317846,0.061524782,0.037764516,0.018626573,0.07321234,-0.079741396,-0.005417411,-0.08789353,-0.053123824,-0.049258836,0.010549682,-0.08324204,0.03608364,0.05947299,0.004117445,0.014016862,-0.014806893,-0.01665177,0.0323575,0.018841665,0.07676755,-0.021543384,0.06297528,-0.033172708,-0.05790467,0.08954347,0.030306933,-0.010099233,0.02818599,0.018339425,0.042378787,-0.0001312973,0.039340798,0.05119508,-0.062204216,-0.0062024184,-0.046382885,0.059108466,0.030331206,-0.0023380565,0.025757568,-0.0037550833,0.082100116,-0.046210337,-0.06320507,0.06612113,0.022152754,0.022504086,0.021244865,-0.103969686,0.04422989,-0.06860394,-0.068803646,0.012629873,-0.01699574,-0.03369447,-0.019598966,0.001498276,-0.039354123,-0.035526387,-0.081666894,0.05930408,0.08056213,-0.05271,0.06638157,0.018069388,0.04031509,-0.08422319,0.03361705,0.05617721,-3.8421362e-08,0.03300026,-0.053145967,0.08055713,-0.084790744,0.020257553,0.015891682,-0.016974093,0.03650951,-0.005946362,0.030791689,0.0023293444,0.051542804,-0.00035225402,0.0702309,0.05327113,-0.00920048,0.055412367,0.012592428,-0.030303383,-0.0048335153,-0.089774035,0.024904786,-0.08461715,-0.024492394,-0.026794996,-0.10538993,0.03872812,0.07717274,-0.017960513,-0.048719212,0.032377034,0.00841994,-0.036644172,-0.08521063,-0.08044754,0.0851216,-0.030780043,-0.13243303,-0.00071982865,-0.04216785,-0.08068981,-0.036994893,0.040399086,0.019018551,0.019823464,-0.043990836,0.07855415,0.006610359,-0.044240646,-0.024851445,-0.0004937456,-0.08468079,0.03408644,-0.11223356,-0.030310754,0.04110684,-0.030659158,-0.04277661,-0.015268478,-0.031589605,0.011128433,0.0024467069,0.18050788,-0.052394573 +6.3.2.65,"The enzyme, discovered in the bacterium Bacillus cereus ATCC 14579, produces the unusual nucleotide sugar UDP-yelosamine, which is incorporated into the capsular polysaccharide of this organism.",384,1.0,-0.06800882,-0.050145317,-0.06374941,-0.039766997,-0.012499601,-0.018316677,0.012052451,0.049281105,-0.008140589,0.047851082,0.07419919,-0.05652685,-0.0019169402,0.065111436,-0.10359529,0.0054791346,-0.043265108,-0.0689802,0.08300054,-0.005311566,0.05658406,0.083698794,0.032505255,0.033597905,0.08706665,0.038319066,0.11389916,-0.07704362,-0.01378418,-0.07165023,-0.02590909,-0.031699277,0.08713622,-0.04084168,0.051065978,0.08918187,0.041873276,-0.033456888,0.09356437,-0.022019777,-0.0026457498,0.019703317,0.049495146,0.049572468,-0.06405007,0.038789555,-0.021193082,0.020644587,0.019244008,-0.0043585314,-0.0052377833,-0.021543944,0.04796295,0.010506523,0.011154987,-0.042742558,-0.05992877,-0.054490726,-0.032973923,0.05421154,0.01601684,0.038855895,0.07283993,-0.0513001,0.057651017,-0.039724246,0.048235316,-0.1009433,-0.029859861,0.0028912134,-0.07281111,-0.0350289,0.011545836,0.059402157,-0.011640384,-0.028650438,-0.011644719,0.00033156452,0.013423139,0.012466892,-0.018280767,0.03354069,0.008147706,0.13049197,-0.0035171348,-0.01383145,0.046596322,0.079386376,-0.006529356,-0.0073284074,0.0001338701,0.023280406,-0.04007131,-0.059276577,-0.095221736,-0.03131401,-0.041949075,0.018685644,0.10891883,-0.023811562,-0.010439453,0.024254214,-0.01691939,-0.093516655,-0.048004024,-0.006681057,-0.018220786,0.00010423043,0.07712647,0.0044958214,0.03708804,0.08174356,-0.005712856,0.004425856,-0.05819563,0.076018825,0.0167763,-0.062326647,-0.09711964,-0.06046283,-0.0072780126,-0.06242854,0.033043955,0.03111552,-0.0771207,0.028405335,-0.055732578,6.796197e-34,0.034662038,-0.03837348,-0.02686055,-0.047715917,0.027181303,0.0046781725,-0.015080997,0.04945714,-0.074589945,-0.051656295,-0.07359883,-0.10984446,0.06697669,0.03619354,-0.016945044,0.018761177,0.01000358,-0.010569231,0.03213413,-0.054016598,-0.054091755,0.069239184,0.07019655,0.0033477475,0.051592555,0.09988167,-0.014663888,0.011052805,0.141345,-0.010898507,0.10536642,-0.03535727,-0.05748522,0.005624448,0.07213831,0.0540922,-0.060933903,-0.029939985,0.0058962153,0.08918868,0.08026182,0.07284477,0.05569806,-0.05128601,0.039106548,0.049261622,-0.05222703,0.06424964,0.044108186,-8.841789e-05,0.014830864,-0.0040644673,-0.0032851477,-0.02632706,0.0039731255,0.02715652,-0.020222563,-0.024473123,-0.051189344,0.065761834,0.0030186868,0.014779884,-0.07030274,-0.013261197,-0.06536155,0.022993932,0.01961639,-0.022114547,-0.0037707963,-0.007836138,-0.058873527,-0.023993595,-0.028463818,0.016946834,-0.055629592,-0.0004914762,-0.013343343,-0.05081628,0.033192087,-0.034926943,-0.02532746,-0.015687369,-0.007750798,-0.036183883,-0.052495234,0.033601217,-0.025251841,-0.004420133,-0.015563047,0.08170191,-0.04121522,-0.09628889,-0.046881936,0.04784167,-0.055520147,-2.32856e-33,0.057956766,-0.11558307,-0.0017746928,-0.061144326,-0.04088923,-0.01325658,0.011542523,-0.05853057,-0.012352145,-0.05550004,0.09978445,-0.019145759,0.04589473,0.037644334,0.054809436,0.05100891,-0.01737429,0.12536035,-0.09438953,-0.014361837,-8.196581e-05,0.095370926,0.042732075,-0.065413535,0.06104383,0.061995152,0.030261982,0.10223852,0.05346635,0.004079,-0.06390757,-0.020700453,-0.04602366,-0.10234447,-0.06513631,0.020405151,-0.004129419,-0.043614633,0.06331648,0.006561966,-0.011713927,0.0930084,-0.043390993,0.012155631,0.055487514,0.039355073,-0.05058213,0.013765148,-0.008793369,0.007925932,0.065310106,0.011864108,0.057493255,-0.042147562,-0.04385575,0.060122427,-0.043806538,0.059206642,0.004565771,-0.07687278,-0.042495243,-0.052950267,0.058895003,-0.010318301,0.020746667,0.05242631,-0.028319558,-0.0019261194,0.030944034,-0.11623261,-0.0013068044,-0.0130840065,-0.021891823,0.058795746,-0.07639669,-0.009009496,-0.11684428,-0.04154584,0.018151436,-0.0135972565,0.013979713,0.031481877,0.018741857,-0.03987468,0.065520406,0.0063683153,0.09525111,0.05937472,0.030126994,-0.002076791,-0.029932257,0.028503051,-0.060494006,0.04784001,0.100709714,-3.230659e-08,0.052270308,-0.056143902,-0.014228716,-0.025694154,0.04103329,0.043672133,-0.014864369,-0.004213418,-0.007063394,-0.064490795,-0.026505781,0.14516653,-0.048647642,0.022250846,0.015453396,-0.028775537,-0.07328918,-0.018708445,-0.036887314,-0.066145524,-0.057752367,-0.011002721,-0.05137114,0.07346672,-0.09095919,-0.010720162,-0.04462332,0.020938624,-0.031137453,-0.049273916,0.0025874746,0.07794674,0.025083603,-0.08734141,-0.051522173,0.030327082,-0.036049947,-0.014910172,0.045556083,0.018108426,0.03353215,0.021289643,-0.07293858,0.013529943,-0.001672661,0.013652416,-0.018084798,0.040809184,-0.036262393,0.070398,0.040742222,-0.013114504,-0.009539827,-0.013495125,-0.050556667,-0.034633335,-0.041299384,-0.093134284,-0.03760481,-0.009064296,0.019372648,-0.034577202,0.1937188,-0.03446999 +1.2.1.108,"The enzyme has been characterized from the photosynthetic flagellate Euglena gracilis. The alcohol is formed by a four-electron reduction of fatty acyl-CoA by NADH. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. cf. EC 1.2.1.84, alcohol-forming fatty acyl-CoA reductase (NADPH).",384,1.0,-0.012381139,0.03933195,-0.11469398,0.034167025,0.008385689,0.025910564,-0.049621157,-0.019862995,0.023732973,-0.011808232,0.07710317,-0.0807512,-0.106949866,0.02059246,-0.017490985,0.02553636,-0.0872764,-0.059834044,-0.007155371,-0.03785163,0.025102837,-0.03205735,0.012067962,-0.020032695,0.08701549,-0.011072123,-0.0031407247,-0.01239108,-0.008946578,-0.09290898,0.022954792,-0.00832899,-0.028763259,-0.04834837,0.08379521,-0.014511323,-0.014318227,-0.057003837,0.038160417,0.029989004,0.04338995,-0.039024394,-0.052960284,0.028991641,-0.11078384,0.04945309,0.012254107,0.09938416,-0.023711747,-0.015600903,-0.0074466104,-0.06480815,-0.058861014,-0.016422784,0.061311763,-0.04090786,-0.00354973,-0.0005355914,-0.027619665,-0.007905463,0.063508816,0.002053434,-0.07860128,0.018684776,0.019661307,-0.07911986,0.01219568,-0.09962904,0.03265302,-0.075389005,-0.04125992,-0.11066294,0.005050209,0.016925303,-0.026998188,-0.011156226,-0.023014618,-0.074774675,0.041198708,0.038319282,0.046292633,0.06498003,-0.011729256,0.10195477,0.06339632,-0.0222165,0.030457044,0.04917204,0.006365517,-0.0020643524,0.0019272281,-0.039165698,-0.099654436,-0.022475727,-0.10212637,0.10040473,0.030843375,-0.008366216,0.029485201,-0.012203799,0.040293865,0.0858082,-0.0073323664,-0.10499997,-0.061344586,-0.019249003,0.005186944,0.11320767,-0.049058028,0.027779693,0.005550221,0.027128108,0.002819837,-0.03003998,-0.022870943,0.09082919,-1.5369642e-05,-0.057392746,-0.07758708,-0.010948831,-0.01884599,0.02362428,0.05634865,0.05964896,0.028991038,0.0187242,-0.11648618,9.729075e-34,0.024371566,0.025973612,-0.022047212,-0.012024344,0.10394447,-0.06098522,-0.08674443,0.0034705254,-0.089889474,-0.018177325,-0.057835925,-0.05186928,0.049587898,0.013355681,0.00033270952,-0.016875397,0.016879128,-0.050385747,-0.010831506,0.032717716,-0.01125759,0.0709378,-0.006749342,0.043428313,-0.010548207,0.028412243,-0.027320372,0.056622755,0.026986761,-0.00049029634,0.02981594,-0.09337929,-0.058671486,-0.0019086375,0.06836175,-0.0030166002,-0.050003316,-0.049716905,-0.026893344,0.013077593,0.047760457,0.07770537,0.04577679,-0.053566836,0.014773052,-0.035971038,-0.06814014,0.09956508,0.05616487,0.03294071,0.11533739,-0.0035157925,0.11490654,-0.016156768,-0.113254994,0.12636663,-0.011656288,-0.008944336,0.023161756,-0.012370599,0.018657384,0.058414675,-0.038183536,-0.0025091704,0.009337586,0.06523042,-0.04205377,-0.024043396,-0.040882885,0.0074169845,-0.0451265,-0.015330301,0.08434367,-0.02031389,0.04366244,0.023072205,-0.035258494,-0.02810157,-0.034317084,0.009120289,-0.013214195,0.026644034,0.023203228,-0.06765987,-0.038577415,-0.035320953,-0.031014826,0.03247744,0.010480028,0.022079853,0.022955611,0.008451704,-0.029396135,-0.060847674,0.01973731,-2.0797527e-33,0.08839409,-0.109468795,0.009145295,-0.16821656,0.0022957076,0.05405807,-0.0139037585,-0.027864408,0.023572946,0.008023212,0.09249615,0.033114333,-0.042834878,0.0025833363,0.01406823,0.00477766,-0.0013354649,0.06873615,-0.0051948326,-0.03720724,-0.027784076,0.09867178,0.045659848,0.01835776,0.015880395,-0.045282446,0.03764992,0.037884302,0.07864044,-0.025523582,-0.008085524,-0.057527095,-0.007128429,-0.037693106,-0.034342684,0.0120753,-0.049891654,0.058184024,-0.0059206034,0.081043705,0.015253213,-0.026368542,-0.03329919,0.036197957,0.09679113,0.0043586525,-0.10020149,0.009690105,-0.029420644,-0.026684286,0.031744275,-0.006073146,0.017929312,0.041546814,0.06212997,0.06031373,0.018744793,-0.053557925,0.042493906,-0.03325634,-0.060157012,-0.066015646,0.01962178,0.018432928,0.077585034,0.012373169,-0.0796394,0.05886857,-0.016010081,0.01750307,0.08316869,0.08437835,-0.08206778,0.069197215,-0.021884697,-0.059597652,-0.055270873,0.013170491,-0.015770175,-0.061586276,0.010070875,-0.02780535,-0.028798595,-0.037644554,0.0076323454,-0.09410354,0.035058174,0.0452829,-0.025074877,0.039152324,0.023534562,0.04718236,0.036874257,0.073768936,0.021916624,-3.4769663e-08,-0.033086445,-0.03148286,0.06860973,0.021583404,0.01745699,0.07946995,0.070189714,-0.0057292227,0.070954315,-0.05396931,-0.021727923,0.05605247,0.060308944,0.014443889,-0.0043700733,0.076854765,-0.015838753,-0.0044344766,-0.019787358,-0.034114517,-0.041038547,0.004154762,-0.06609386,0.07482716,-0.07138411,-0.007977808,0.04713475,-0.006407881,-0.042267866,-0.040583793,0.012317467,0.10098457,0.06081813,-0.052176513,-0.09207997,0.020006081,-0.017233418,-0.04423541,-0.04060221,0.09220519,0.019947184,-0.0050451164,-0.051604327,-0.0059719807,0.033931796,0.0262494,0.002030907,0.009493978,-0.012946072,0.045472134,0.112088144,0.07879482,-0.019709181,-0.044481736,-0.12275867,-0.0028961443,-0.042688664,-0.053083565,0.02554839,-0.029913787,0.08813216,0.00785136,0.1831405,0.051421516 +1.8.4.17,"This enzyme complex, usually referred to as the sHdr system (type I), is a cytoplasmic sulfur oxidation system found in many bacterial and archaeal sulfur oxidizers. The system consists of a dimer of the iron-sulfur flavoprotein sHdrA and one subunit each of the proposed catalytic subunit sHdrB1, the disulfide reductase sHdrB2, and the ferredoxin-like electron carrier proteins sHdrC1 and sHdrC2. The system oxidizes a sulfane sulfur, provided by the TusA sulfur-carrier protein, to sulfite, using a dedicated lipoylated protein (LbpA) as the electron acceptor.",384,1.0,-0.06865866,-0.011989587,-0.08661657,-0.08011723,0.09156609,0.022307662,-0.023885716,0.029231489,0.03915529,-0.04866812,0.0139020495,0.018841162,0.0028565791,-0.032141138,-0.044526957,0.0064588343,-0.06365992,0.03861001,0.030154364,-0.024603909,-0.0023452502,0.038366944,-0.04172278,0.003762734,-0.038503736,0.12182286,0.035510167,-0.034777626,-0.098176286,-0.084022686,0.056977693,-0.012693091,0.018445233,-0.07407144,0.002936426,0.08720882,-0.036680777,-0.037053972,-0.013042189,-0.069960244,0.023552392,0.01143308,0.028386392,-0.05134679,0.0050310683,-0.04323721,-0.055692192,0.03228003,0.020722311,-0.058789764,0.019244652,-0.033864573,-0.0003781709,0.103827916,0.03706527,0.0041476362,-0.09307307,0.001828069,0.047430694,-0.037095807,-0.07507003,0.0344754,0.071924515,-0.08601551,0.093856476,-0.071230866,0.016283857,-0.075273395,0.043200046,-0.03412855,-0.048048425,0.017833915,-0.05434237,0.059647802,-0.008795125,0.03303391,-0.017050723,-0.015791852,0.09353232,0.011837338,-0.0060237935,0.04170538,0.04095473,0.12533073,0.060396105,-0.024659887,-0.04578031,-0.038341396,0.025575943,0.03617599,0.024445355,-0.013232811,-0.0003376494,-0.0070158895,-0.08998785,-0.018513119,-0.0060565346,0.14222129,-0.024601035,0.015178373,0.019935472,0.03874142,-0.018487798,-0.14234748,-0.035056833,-0.04069663,0.02161531,0.13690443,-0.0073446436,-5.9036905e-05,0.022131914,-0.06985796,0.05629911,-0.043056265,0.012026812,0.09282823,0.005678694,-0.02849084,-0.07859648,-0.036653817,-0.0016474631,0.03321846,0.02605589,0.024772638,-0.062771656,-0.0049613677,-0.12135571,2.9798484e-33,0.0538277,0.049792018,0.04446426,0.044786133,-0.116207585,-0.04653411,-0.079490945,0.046449997,-0.016134674,0.0033002757,-0.1109339,-0.054898832,-0.018523887,0.007644638,-0.004291999,-0.069080964,-0.038972832,0.01453114,0.075384766,-0.0012343246,0.045165583,0.04396929,0.005491817,-0.049443517,0.0684161,0.026572447,0.015782835,-0.05264771,0.016736718,0.029714422,0.10802646,-0.0712846,-0.063463934,-0.013966235,0.060436375,-0.035349447,0.020485798,-0.0073005864,-0.027582724,-0.020361442,-0.022180716,-0.0060847932,-0.025030944,-0.030434277,0.043196622,0.031900063,-0.02335272,0.055804543,0.01687579,0.0037349833,-0.021979982,-0.022644041,0.102233544,0.024527177,-0.044939533,-0.0032448675,0.06347787,-0.027945329,0.024179257,0.112227805,-0.00943356,0.10250106,-0.05412141,0.02838901,-0.005657117,-0.009472447,-0.04057924,-0.05541282,0.01496196,0.04934719,-0.0016711071,-0.002852715,0.06317537,0.051490024,0.01668648,-0.039238624,0.0037189953,0.0023285716,-0.009603324,0.04529862,-0.0031190391,-0.081927195,-0.018310243,-0.025160927,-0.041503727,-0.069995694,-0.031745896,-0.032060746,-0.07482419,-0.039410263,0.0050025685,-0.07935784,-0.05033999,0.017790312,-0.037376486,-4.1659222e-33,0.009259854,-0.07005374,0.04738975,-0.09861306,-0.025088962,0.115586236,0.016156154,-0.014659927,0.041965336,0.024463208,0.05882005,-0.025123296,0.03108546,0.010425652,0.07942533,0.06484171,-0.096390255,-0.026190206,-0.05552476,0.012863322,-0.07506475,0.07416771,0.01719375,0.08047366,0.02989988,0.06682549,0.009067441,0.05817797,0.09530437,0.09404462,-0.044561543,0.0024902723,-0.035240773,0.027248813,-0.04353919,0.08377868,-0.034285545,-0.0025145512,0.018361004,0.010145014,-0.039552677,-0.02454986,-0.036117572,0.015177878,0.03407478,-0.012024883,-0.02523561,0.110546276,0.0237319,-0.010584883,0.033815943,0.01373904,0.03300144,0.016209384,0.008007015,0.014243533,-0.0071257753,0.009564305,-0.063947126,-0.017785251,-0.037645306,-0.07864298,0.0029705123,0.0474975,-0.04053662,-0.007851371,0.0038847814,-0.0875681,0.021061959,-0.06768457,-9.9949786e-05,-0.02909698,0.085404985,0.025381379,0.04232163,-0.066057794,-0.049776517,0.0848585,0.00017109637,0.01928517,-0.05857876,-0.03257831,0.11555883,-0.08873196,0.13281052,-0.06158496,-0.010282081,0.059485003,-0.002272402,0.054754168,-0.038474336,0.03204568,-0.050761987,0.07070622,-0.03344631,-3.9495678e-08,0.033308133,-0.08583933,0.056819286,-0.0029836434,-0.0045749783,0.027387748,0.021448579,-0.048348878,-0.04256105,0.004486183,-0.0020812012,0.15399227,-0.024974564,-0.03343205,0.082130924,0.069206044,-0.018353695,0.02009608,-0.018501665,-0.053148787,0.031699955,-0.034088276,-0.041940488,0.041471913,0.0061886925,-0.041591197,0.02310952,-0.020650893,-0.02550561,0.0007237899,0.051235627,0.051777605,-0.07452761,-0.044016264,-0.0059107174,0.062537886,-0.021561578,-0.053675536,-0.011908925,0.04434222,-0.039264254,0.02339703,-0.10410156,0.011624659,0.07404428,0.05830109,-0.012269968,0.053551517,-0.052746862,0.0013738422,-0.020525862,0.012412488,-0.020288277,-0.035813704,-0.09796189,0.07710517,0.01091895,-0.08013253,0.051213898,-0.030801544,0.042912908,-0.014683527,0.12647565,-0.022233222 +1.8.98.8,"A flavoprotein (FAD). The enzyme is found only in methanogenic archaea living in deep-sea volcanoes, and requires high partial pressure of hydrogen, which effects the reducing potential of the F420/F420H2 pair. cf. EC 1.8.1.9, thioredoxin-disulfide reductase (NADPH).",384,0.99999994,-0.07617516,-0.04107889,-0.08589549,-0.009635174,0.12715991,-0.013243556,-0.081817165,0.07549033,0.038357057,-0.027035477,-0.014752631,0.008703486,-0.08639258,0.011615022,-0.066995665,0.013943676,-0.04064097,-0.028205372,-0.04712766,0.00011953216,0.009356551,0.051494643,0.019262094,-0.026082557,0.008833173,-0.0035713715,0.0055275336,-0.0120426025,-0.033702277,-0.044527903,0.0446211,0.007334198,0.058790054,0.0051260567,-0.0027151988,0.111005336,-0.005317762,-0.028329683,-0.0050437236,-0.0065362034,0.0012997221,-0.03384816,0.0767444,0.02111366,0.028778719,0.031593118,0.0045866375,0.020641848,0.016670233,0.01246102,-0.028247664,-0.017123695,-0.051156685,0.043061946,0.0061328243,0.029739123,-0.010093659,-0.070510454,-0.014102496,-0.023252632,0.04431627,-0.016685104,0.033761244,-0.027405825,0.065080956,-0.047005735,-0.008987855,-0.023963585,0.04998403,-0.02863308,0.020543559,0.027608337,-0.044751886,0.002974969,0.01903298,0.03214026,-0.065932736,-0.048164845,0.072601154,-0.025820302,0.09652893,-0.0046553155,0.081341594,0.058109354,0.0698518,-0.037605483,-0.012376103,-0.05462731,-0.053228334,0.049631223,0.008360165,0.0042773574,-0.027571272,0.006113897,-0.10982796,0.055949435,0.037237123,-0.012407684,-0.062545955,-0.007979395,-0.037764497,0.0125760045,-0.050342727,-0.03986123,-0.054070767,-0.05323646,-0.02688067,0.12546518,-0.025406452,-0.0013465001,0.003975071,-0.025548695,0.043792505,-0.0688449,0.02360154,0.014433473,-0.028518802,-0.074320406,-0.0934004,-0.04892026,-0.0606766,0.044633266,0.04102572,0.08450145,0.023204757,0.010895129,-0.17179485,2.5353727e-33,0.12106435,0.009314111,-0.026796643,-0.031602245,-0.010197102,-0.022740146,-0.06276704,0.004879421,-0.028442202,-0.042593364,-0.067394756,-0.031078024,0.0016244348,-0.066413805,0.009364588,-0.019325696,-0.0010806365,-0.02813196,0.021936603,-0.101683736,0.048694897,0.050276253,-3.7839134e-05,0.003635758,0.04339936,-0.0030722453,-0.025840156,0.024755519,0.02357696,0.027204582,-0.023290107,-0.09711398,-0.07082005,0.04438336,0.053524226,0.058354627,-0.09840718,-0.063832946,-0.115613535,0.04387205,0.028430944,0.031032661,-0.0065652607,-0.013002444,0.09114903,-0.054093745,-0.023197647,0.09594485,-0.008028828,0.09137126,0.0077540544,-0.020239612,0.08434791,0.066456385,-0.05986231,0.006930666,-0.025202937,-0.019414963,0.026492577,0.058208957,0.0023347284,0.07102573,-0.021518733,0.11124179,-0.06187367,0.03257276,0.011686539,-0.06390818,0.03171637,0.144499,0.03958299,-0.007980995,0.07010763,-0.022190815,0.027653959,-0.065013476,-0.0068679163,-0.068188705,-0.007445044,-0.005491188,0.0041817203,-0.04728133,-0.017780967,0.010616595,-0.04843607,0.046070885,-0.015556824,-0.06844185,0.040009025,0.03396759,0.014839648,-0.08578273,0.025933301,-0.060732033,0.027479822,-1.0061591e-33,0.05592438,-0.098648995,0.045333803,-0.005414851,-0.0032215521,0.06543445,0.025154328,-0.02686638,0.029386071,-0.05507797,0.051874664,-0.04910566,0.01406649,-0.036469646,0.0655039,0.02663329,-0.033518802,0.016444,0.06320011,0.005063645,-0.048363365,0.031033024,0.041724946,0.08451056,0.030834794,-0.011445026,0.001237821,-0.00214355,-0.004271514,-0.00055859634,-0.061183564,0.09823586,-0.088881806,-0.014227152,-0.11600522,0.040409125,-0.043288775,0.002516311,-0.031697404,0.03251427,0.009999516,0.05217665,0.0013163274,0.037457198,0.024607541,0.07469132,-0.03276769,0.05299833,0.12170321,-0.05818509,0.03941489,-0.02418643,-0.008984414,0.05822301,0.045680974,0.017291624,0.011847372,0.09520707,-0.01725981,0.0046682023,0.026494963,-0.13948868,0.024371618,0.011790612,0.100713596,0.042183917,0.051688217,0.16006328,-0.01194631,0.053388488,0.112319164,-0.012864914,0.058862932,0.10061948,0.03696051,-0.043828294,-0.027459579,0.08666578,0.034632504,0.04736901,0.041259915,0.037278153,-0.0013310241,-0.008512493,-0.0083270855,-0.10591051,0.032821614,0.0567912,-0.036338575,0.043613926,-0.060471542,0.039096523,-0.021605073,-0.06408334,0.04067113,-3.6681996e-08,0.06505472,-0.008076099,0.015439065,-0.046459015,0.06919363,0.020130971,0.022789005,0.038044292,-0.005293881,-0.004642764,-0.071930654,0.12509866,0.05789389,-0.07375211,0.048120487,-0.021519631,0.01585659,0.0108301025,-0.061177243,-0.0063630193,-0.026484715,0.053903062,-0.124332756,0.022651935,-0.03309042,-0.0020783215,0.046884086,-0.04256516,0.031722374,-0.033679783,0.0030468164,0.012780754,0.027001286,-0.07273059,-0.08353528,0.07204642,-0.009679723,-0.026444921,-0.08903104,0.04429855,-0.103652455,-0.00987187,-0.015574825,-0.023053028,-0.030181136,0.007792902,0.037523933,-0.005356724,-0.07553403,0.00331202,0.0145499585,0.00529714,0.034027893,-0.040661424,-0.09405111,-0.0013880063,-0.009178469,-0.042959683,-0.075456925,-0.075250946,0.061698683,-0.0040580286,0.09952491,0.019992372 +1.11.2.7,"The enzyme, characterized from the mushroom Calonarius odorifer, catalyses the regioselective coupling of two molecules of the phenolic compound (R)-torosachrysone at the corresponding C7 and C10' positions, forming the 7,10'-coupled dimeric product (phlegmacin). The enzyme produces both atropisomers of the product.",384,1.0,-0.042260647,-0.027145348,-0.070895456,0.00049008825,0.0720294,0.08348658,-0.0568724,0.01500872,0.08911237,-0.036331095,0.09942833,-0.040548787,-0.086431436,0.027791383,-0.038446512,0.0038716306,-0.09374421,0.08909347,-0.032198157,-0.019243391,0.106341176,0.032879986,0.010179874,0.06626864,0.0037202095,0.00084395043,0.06023645,0.0060679,-0.038813177,-0.06676635,0.034350727,-0.056060962,0.037090737,-0.00023215098,-0.022773607,0.05196323,-0.027812734,-0.048127238,-0.008026948,-0.008208371,0.028033372,-0.041984107,0.03684315,-0.031659264,-0.09692673,-0.07256509,-0.026728023,0.02434492,0.04912279,-0.011091378,-0.07005399,-0.05160684,-0.0151090035,0.049950954,0.00992652,0.10106426,-0.03490446,-0.021528693,0.009766706,-0.030369787,0.07020113,0.007899817,-0.089567095,-0.0075374385,-0.07251664,-0.031234412,-0.018407278,-0.04238248,0.030759856,0.0081392145,-0.023249025,-0.0056273397,-0.01775086,-0.0067455727,0.08451873,0.07130338,-0.0430091,-0.020912303,0.026419599,-0.035543833,0.076824784,0.051201977,-0.022859773,0.036714662,0.037073974,0.02377089,-0.013294515,0.035466798,0.028858228,0.023815958,0.06671987,0.015040544,-0.04725646,-0.08087774,-0.14942019,0.018461227,0.069884375,0.07549463,0.028482521,0.01214854,0.03553398,0.03861485,-0.016400471,-0.11477243,-0.01079042,0.039128777,-0.055045817,0.020952674,0.08796634,0.00031775492,0.041046582,-0.05642033,0.042270053,-0.055610944,-0.041788135,0.066574566,4.006737e-05,-0.0010954498,-0.036193684,0.0018673646,0.004443143,-0.009644772,0.017853629,0.0439334,-0.004408912,-0.07303449,-0.12304643,1.3671516e-33,0.0581426,0.04591401,-0.023920704,0.01669312,0.0039179907,-0.03590611,-0.06442249,0.011675218,-0.061738063,-0.0059923464,-0.11352989,0.030985001,-0.100361295,-0.0006523699,0.04497632,-0.03185669,0.0026923146,0.0021470168,0.05706176,-0.029987155,0.024319552,0.07309201,-0.07165694,0.012333212,-0.019158887,0.0037570547,0.006685936,0.024139743,-0.016851371,0.0008359495,0.099993244,-0.016052924,-0.09028922,0.035222646,0.030310761,-0.0019783399,-0.030379891,-0.028291296,0.020946676,0.06988107,-0.047760125,-0.0005100273,0.04101241,0.025931222,0.050038207,-0.015796587,-0.026898876,0.077264816,0.14932628,0.073279135,0.057311505,-0.014733259,0.10670384,0.068773754,-0.07232491,0.06909156,-0.041011292,-0.011403,0.0136754885,-0.008289258,0.03772685,0.05337349,0.015504648,-0.008125356,-0.055936854,0.012660824,0.011537473,-0.037221164,0.030746907,0.052236047,-0.028747749,0.027173197,0.014732106,-0.00073663436,0.03775207,-0.011242368,-0.033656154,-0.061957218,0.017289383,-0.010509311,-0.10083133,-0.007943402,-0.0043293806,0.03320125,-0.121008575,0.032339294,-0.0465021,0.026773598,-0.036088966,0.06643573,0.005742631,-0.056980964,-0.05040519,0.03226323,0.00482836,-1.4261911e-33,0.092941165,-0.11273957,0.084931195,-0.0131914215,-0.04914685,0.056469534,-0.015105567,-0.022104735,-0.11245507,-0.094675906,0.048427075,-0.0029523363,0.04985602,0.015281035,0.058986384,0.10686893,0.008050873,0.038899668,0.026865166,-0.024634011,-0.0020803884,0.038923874,-0.06877176,0.06824417,0.0042768535,-0.03455872,0.09788103,0.024700096,0.1075528,0.07505797,-0.011354879,0.006297574,-0.015886664,-0.015499827,-0.08140123,0.06778447,-0.04636174,-0.0020377692,0.021940453,0.03915233,0.01648947,-0.047164828,-0.090872854,0.006455063,0.06385087,0.020116063,-0.012588497,-0.047062203,0.05675186,-0.054127038,0.08223088,0.06824425,-0.03261962,-0.047154047,-0.030483948,0.070444316,-0.039082065,-0.038632706,0.020128544,-0.050183818,-0.022814339,-0.09581191,0.006104776,-0.031660624,0.031356193,0.096283525,0.008162295,0.0013059475,0.022349128,-0.056422815,0.07591563,-0.011249644,0.018200139,0.052887544,0.011300819,-0.086657435,-0.007823475,-0.056464724,0.01011926,0.027517283,-0.008790057,0.027247207,0.01563782,-0.055823434,-0.010641856,-0.05178267,0.07547389,0.065281786,-0.022523249,0.044952136,0.04265987,0.0901822,-0.009350826,0.005876452,0.10249531,-3.753877e-08,0.029119322,-0.07337578,0.03199793,-0.067329496,-0.024380488,0.029392773,0.065077394,-0.040568627,-0.038812704,-0.022779113,-0.049685705,0.06507974,-0.029143691,0.0806262,0.050006982,0.042064272,-0.05424711,-0.0065649394,-0.04600847,-0.004014654,-0.07829718,0.069416046,-0.09943175,-0.02075639,-0.049289286,-0.032666903,-0.024494438,0.0854449,-0.026795242,0.008946245,0.019337773,0.023728942,-0.050350215,-0.023818528,-0.05655307,0.061421745,-0.07948582,-0.07519677,-0.020740833,-0.03823692,-0.018843852,-0.035953134,-0.03804479,0.04965222,-0.010532951,-0.032615725,0.04152102,0.047365908,0.009338606,0.047100697,0.054513223,0.045456257,-0.017992545,-0.07101079,-0.1063124,-0.043746658,0.07227435,-0.013149838,-0.053412538,-0.02668936,0.056251913,-0.01607474,0.12833339,-0.082233444 +1.11.2.8,"The enzyme from the bacterium Actinomadura luzonensis is involved in the biosynthesis of the antitumour and antiviral depsipeptide luzopeptin A. Contains a heme b cofactor. The enzyme can use O2 (and ascorbate) instead of H2O2, but the reaction with H2O2 is at least two orders of magnitude faster. cf. EC 1.14.16.4, tryptophan 5-monooxygenase.",384,0.9999999,-0.06982614,0.0066272905,-0.11777128,-0.027043592,0.09318095,0.027193686,-0.03888437,0.079642616,0.027734835,0.055020083,0.068783924,-0.09177982,-0.1286627,0.026467511,-0.060883284,0.0878897,-0.011296342,0.0059204493,0.04528095,-0.026979487,0.068203576,0.06322379,0.0021041946,0.036575597,-0.01968772,-0.03211527,-0.00074810855,0.028319363,-0.028341053,-0.072012916,0.008792505,-0.040416677,0.09739454,-0.055597365,0.03612269,0.057299614,-0.027432926,-0.057987202,0.06368828,-0.0036334388,0.0258244,0.025276516,-0.0007816519,0.02966124,0.0032265405,0.006431185,0.0020752873,0.059307303,0.03342211,-0.0041484577,-0.08383655,-0.021124,-0.09766051,0.030686064,0.0032120866,0.04928318,-0.03076444,-0.0051350435,0.0049038166,-0.004050593,-0.00069289206,0.044809632,0.08099491,-0.012924327,0.0032307822,-0.04720212,-0.03205073,-0.06074521,-0.030966975,-0.0064816624,-0.084092,-0.06402839,0.03691146,0.022755746,-0.043539926,0.023111265,-0.013291707,0.003591069,0.0124399755,-0.09010962,0.03803151,-0.049219456,0.07855707,0.15883364,0.006140767,0.020919684,-0.024285367,-0.013839799,0.032241724,0.023403889,0.009945616,-0.012528774,-0.022725834,-0.068515874,-0.013882317,0.038187675,0.0077906605,0.023403998,-0.007936071,-0.008071206,-0.021984465,0.008020664,-0.061182298,-0.108911,-0.041072458,-0.025449608,-0.0004474678,0.017891021,0.13573037,-0.031682976,0.014432914,-0.012130711,0.016065191,-0.033385586,-0.016224628,0.011352124,0.06329017,-0.06669973,-0.11481036,0.008970241,0.053388856,-0.014862918,0.072108634,0.012891645,-0.027320253,-0.00898943,-0.08380126,4.4163018e-33,0.066059716,-0.02390503,-0.006059093,0.0008510632,-0.08017995,-0.0015770947,-0.06901009,-0.019940998,-0.06328617,-0.058321215,-0.071738645,-0.12908539,0.07113507,0.034989975,0.008949264,-0.031053742,-0.030253612,0.0012328469,0.03592937,0.012721504,0.029860556,0.031082617,-0.09210299,-0.04526837,0.075929835,0.104870394,-0.037979502,-0.027645921,0.08535113,0.0018051566,0.017217584,-0.021295652,-0.15343794,0.046977658,0.043751102,-0.053609923,-0.05814583,-0.066423,-0.010537335,-0.0058768843,-0.006061451,0.079863206,-0.009250726,-0.033652537,0.09300955,-0.034317095,-0.036622368,0.08839588,0.1646667,0.10552732,0.02301708,-0.027347364,0.1294258,0.014346087,-0.036216136,0.028853707,-0.028726464,0.06776749,0.10255078,0.0795539,-0.011918632,0.017180892,-0.045766238,-0.0045511667,-0.0047285496,0.009236393,-0.014834414,-0.074150115,0.017778313,-0.013743277,-0.0129297925,-0.040129427,0.07551204,0.008008552,-0.04097992,-0.03184449,-0.01679287,0.047246285,-0.008237201,0.01015396,0.012625408,-0.003729005,0.031621195,-0.04996695,-0.00987276,0.03633358,-0.006833323,-0.081039436,-0.0428917,0.03762314,0.017788658,-0.07629489,-0.12551923,0.012917385,0.0436976,-4.54636e-33,0.09052651,-0.07360109,0.030416217,-0.06569414,-0.05732168,0.072373666,0.006107589,-0.09432335,-0.030280013,-0.008448994,0.0918057,0.00018320119,0.0080593,-0.048075236,0.04387761,0.0067811403,0.020899937,0.12324184,0.019418562,-0.06305073,0.043663763,0.08126653,0.025265073,-0.018509176,0.060303908,0.032011375,-0.01943981,0.04543558,-0.004555148,0.031737037,-0.04707152,0.039842825,-0.103055745,-0.06287686,-0.03506713,0.037802555,-0.074970454,0.047721975,-0.012968104,-0.047716375,0.039194133,0.014077265,0.06331256,0.031534374,0.002569848,0.10794319,-0.09669937,0.040956844,0.05800843,0.0062941294,-0.0019060015,-0.020960255,-0.044108793,-0.011335423,0.029935008,-0.0027470062,-0.004311137,-0.021811986,-0.03134164,-0.04504603,-0.008489798,-0.02194369,0.061368104,0.037945863,0.052355833,0.09327914,0.0133934375,0.05563552,0.089238614,-0.06194608,0.07045311,0.027093297,0.044357628,0.06287752,-0.031321798,0.018967925,0.018024426,-0.041913565,0.04123245,-0.009530605,-0.0113854725,0.022336705,0.009288024,9.0408075e-06,-0.07179119,-0.056933608,-0.014230237,0.018609578,-0.02847383,0.006838288,-0.031736,0.026794307,0.029438343,0.012047113,0.018356996,-4.2261817e-08,0.028977294,-0.073933154,0.13778907,-0.07162657,-0.0050464706,0.0330577,-0.050718255,0.035318486,0.06552685,0.019636706,0.023339808,0.039730802,0.041252393,-0.028452542,0.00673211,-0.005551629,0.018814195,0.021892989,-0.05541716,-0.01969467,-0.06767326,-0.008841759,-0.075429186,0.021634731,0.03319433,-0.08665624,-0.017716128,-0.059113625,0.029307026,-0.028853722,-0.029717902,0.028041126,0.0022265948,-0.037316896,-0.051651374,0.0056266706,-0.07468528,-0.03125161,-0.033695582,-0.0068286606,0.011476528,-0.037320126,0.00576088,-0.007863471,0.020774784,-0.017211203,0.017582336,-0.05641289,-0.022269184,-0.05122308,0.040058468,-0.004626167,-0.007400617,0.007549007,-0.13291715,-0.011949204,0.051318824,-0.053748623,0.017180417,-0.009142616,0.011756024,-0.007214754,0.16765507,0.053087156 +1.14.14.191,"A cytochrome-P-450 (heme thiolate) enzyme. Demonstrated in the plant Taxus mairei (Maire's yew). It is involved in the biosynthesis of taxol (paclitaxel). The reaction involves epoxidation of the 4(20)-double bond followed by rearangement giving the oxetane ring. The reaction was demonstrated using taxa-4(20),11-diene-2alpha,5alpha,7beta,9alpha,10beta,13alpha-hexayl hexaacetate.",384,0.99999994,-0.04677782,0.05439491,-0.051403955,-0.033401836,-0.0016093603,0.060038418,0.014833564,0.06667415,0.03223498,0.044961333,0.011007525,-0.01789359,-0.043952867,-0.053123374,-0.04690961,0.016150316,-0.08269853,0.021894066,0.0021762499,-0.031682868,0.116467595,0.00706066,0.05035476,0.035778455,-0.030648425,-0.030153971,-0.02160707,0.049497735,-0.052860256,-0.10050217,0.025441648,0.02396159,-0.010697296,-0.015753044,-0.033253733,0.06883987,-0.031666387,-0.03196542,0.021767218,-0.023707224,0.05100161,-0.019802252,-0.10807861,-0.014905844,-0.089024395,-0.073852986,0.01291693,-0.041297127,0.06856005,0.016660076,0.0016994767,-0.03213754,-0.038747657,0.010430335,-0.0036599606,-0.030917747,0.03700968,0.0074864076,-0.030475546,-0.036086116,0.007340065,0.010559237,-0.030531107,0.022105718,-0.07154032,-0.00068565004,-0.0503905,-0.033461273,-0.047020387,-0.103789344,-0.041100454,-0.08397708,0.013460899,0.0246163,-0.09011696,0.053695273,-0.013674703,0.013497675,0.015119661,-0.032411817,0.015795242,0.02601859,0.01680047,0.106275715,0.04923862,0.04587625,0.044353463,-0.006787288,0.08109567,-0.023268446,0.029888881,0.09395636,-0.061958022,0.015033988,-0.046338093,0.017433202,0.078486525,-0.024549458,0.007058634,0.002099299,0.0877336,0.043597896,-0.055450957,-0.1549617,-0.075789906,0.029204296,-0.058896348,0.01071248,0.06302129,-0.07569253,-0.03060656,-0.026735064,-0.03901177,0.028332861,-0.04559808,0.13108316,-0.040722337,-0.090049095,-0.04878362,-0.12570034,-0.06311943,-0.057208817,0.017848078,0.0017177477,-0.007730451,-0.043595433,-0.02692243,3.0537716e-33,0.04294376,0.04574803,-0.010817806,-0.022806466,0.046777174,-0.026574187,-0.046588734,0.038499232,-0.059279293,-0.0303686,-0.11522958,-0.0728513,-0.026088802,-0.042532608,0.012801917,-0.024727311,-0.021075865,0.03550529,0.045455355,-0.0044298093,-0.0292674,0.023437278,-0.01416199,-0.004441996,-0.03635154,0.13068324,0.0008910858,-0.02912014,0.03115966,0.007863266,-0.025180975,-0.056601457,0.0059948443,-0.034304295,-0.024238853,0.030540414,-0.03433938,0.029730448,-0.05429301,0.060129963,0.018329002,-0.01554299,0.097113624,-0.060928486,0.028775696,-0.026024835,-0.06914434,0.053214278,0.077855065,0.063351765,0.0048685726,-0.040198985,0.113317005,0.040357724,-0.08291334,0.07228282,-0.048793644,0.024920097,0.023806144,0.05490193,0.12455903,0.03548812,-0.026810024,0.04951432,0.007791696,0.09759318,-0.06097225,-0.0062040514,-0.0015618758,0.13464275,-0.056650903,0.021213548,0.026375355,-0.021197557,0.09144858,0.011462298,-0.016074752,0.056874976,-0.0051974407,0.0789439,0.015320057,0.022473048,-0.021852262,-0.01664304,0.010834667,-0.009502039,0.016727665,0.080131166,-0.022433763,0.071418844,0.08440816,-0.09415497,0.023909155,-0.019085445,0.005769612,-4.127756e-33,0.08118002,-0.080183946,0.058249757,-0.06739959,-0.022913089,0.081077635,-0.005900486,-0.010789094,-0.052988753,0.031058371,0.067878045,0.024239805,0.02500497,-0.019907765,-0.05151036,-0.029812966,0.05061397,0.05145679,-0.016684469,-0.017466893,0.0042509953,0.053467125,-0.020129671,0.019820364,-0.008242451,-0.0024975087,0.03399396,-0.002225147,0.048822124,-0.002466015,0.04798974,0.030197335,-0.037429698,0.0070630917,0.0016697914,0.023366293,-0.012520778,-0.030829446,0.03778609,0.092653014,-0.078707404,0.0061681177,0.05776852,0.030557554,0.058876358,-0.0038034834,-0.14081109,-0.03848168,-0.04985746,0.024331257,0.051525906,0.06197685,-0.055291697,-0.022323517,0.030342197,0.044901952,-0.019127894,0.00029300305,0.009355137,-0.05194356,-0.039619632,-0.028126478,0.007774962,0.051539246,-0.023369,0.08216686,-0.041738313,-0.009841811,0.057489056,0.04342494,0.07170758,0.006152366,-0.046296686,0.06866817,-0.012653306,0.008177733,0.04145689,-0.008440021,0.04404457,0.0053738025,0.004901789,-0.02357737,0.007755142,-0.10350684,-0.081884876,-0.06761133,-0.025766471,0.08360578,0.05100419,-0.03835198,0.02608197,-0.003142214,0.004314996,0.03019007,0.06184813,-4.9577242e-08,-0.02678165,-0.090334594,0.016630758,0.03304731,-0.04070311,-0.031205589,0.024400797,-0.0023832761,0.0448642,-0.12576808,0.031768437,0.08253559,-0.028657079,0.0063045262,0.011207248,-0.012093698,0.02122331,0.06341202,0.0019352701,0.02788314,-0.07618352,-0.0035928849,-0.085861884,0.022083005,0.02435309,-0.0787511,0.03248243,-0.005870422,0.018667703,0.006679216,0.032971185,0.042167775,-0.09764458,-0.068542644,-0.029262928,0.037667554,0.0017098134,-0.03411967,0.012963219,0.0064928676,0.04724039,-0.12098149,-0.03594786,-0.01742004,0.013531994,0.027228128,0.041862894,-0.037990168,0.0031608439,-0.04351184,-0.013608957,0.050548736,0.017062543,-0.12554927,-0.13807447,0.012780933,0.039808698,-0.052158166,-0.040367454,-0.10499407,0.034351055,-0.008900498,0.2028536,0.024394017 +1.14.14.192,A cytochrome-P-450 (heme thiolate) enzyme involved in paclitaxel (taxol) biosynthesis. Isolated from the plant Taxus baccata (English yew).,384,0.99999994,-0.007876347,0.010499738,-0.095878385,-0.0107577015,-0.009816902,0.0731874,0.032401484,0.05163861,0.042977933,0.018770514,0.018083692,-0.00245747,-0.023059884,-0.041238684,-0.018182136,0.01128191,-0.057678066,0.0010392062,-0.008756537,-0.012184609,0.09514231,0.039727494,0.073930584,0.101222165,-0.036269695,-0.039655257,-0.023124738,0.056790885,-0.022451282,-0.07991161,0.0014030517,0.017397385,-0.0003932237,-0.031639133,0.036821656,0.046175282,-0.037037164,0.025908422,0.06628143,0.02201249,0.035204098,-0.055576287,-0.09716738,0.012720707,-0.089753896,-0.07161692,0.0013502764,-0.032190993,0.074924715,0.026746947,-0.028434897,-0.020486506,-0.055425446,0.031796392,0.0038901116,-0.033561494,0.021375919,-0.0053328467,0.0067994636,-0.0129540665,-0.031956416,0.046541158,-0.009521503,0.020544335,-0.036210656,0.033492163,-0.047142975,-0.005815187,0.009002229,-0.09059457,-0.07419019,-0.088971846,0.01459053,0.05420001,-0.09766631,0.04283124,0.03483727,0.04253387,0.024437968,-0.06710538,0.059824254,0.029140867,-0.008115886,0.12846652,0.018819908,0.012663126,0.074145444,0.06329767,0.09744938,-0.026690478,0.006751167,0.079139076,0.00037149165,-0.023142284,-0.049548678,-0.004925207,0.053226616,-0.022551432,0.009838489,0.008135406,0.072292246,0.0134385275,0.014855677,-0.14961274,-0.076765634,0.026052158,-0.09658624,0.025568193,0.05611103,-0.06600677,-0.035701085,-0.012844042,-0.046345152,0.03136521,-0.01753715,0.10108566,-0.030041434,-0.10403317,-0.055919543,-0.11301818,-0.023448462,-0.07059356,0.041052934,-0.006296491,0.007278711,0.016006595,-0.04318959,1.7238737e-34,0.04734002,0.0053657545,0.010564911,-0.0339568,0.05714252,-0.023556337,-0.034338318,0.025239306,-0.12976536,-0.0005837629,-0.11224708,-0.07842929,-0.06692231,-0.03361004,0.033146795,0.0051133474,-0.049850497,-0.0040569794,0.033250343,-0.02131312,-0.01718209,0.08379587,-0.033910334,-0.021185493,-0.033232044,0.09967938,-0.03232951,-0.032127913,0.009807841,-0.002993802,-0.0037554363,-0.07668043,-0.008529459,-0.03577428,-0.0022876647,-0.0034739845,-0.04032694,-0.007563015,-0.03718582,0.048066318,0.02497938,0.017741458,0.13171934,-0.048749927,0.018758675,-0.005350133,-0.06352229,0.027037285,0.06930911,0.05336333,-0.010309876,-0.00024087323,0.096586354,0.030082967,-0.08172179,0.04111491,-0.029887313,0.058588486,0.00967624,0.05978334,0.10129928,0.028675674,-0.035476714,0.058501553,0.015126565,0.05175715,-0.0725335,-0.0051342323,0.042841047,0.09358195,-0.07911338,0.015815826,0.03557968,-0.05704154,0.091567405,-0.014890401,0.004372949,0.011351579,-0.03413893,0.051561438,-0.030506765,-0.0070541883,-0.0077163223,0.0461599,-0.026629496,-0.015039372,0.018302377,0.07024937,-0.08141424,0.023956817,0.0161508,-0.06464058,-0.007022549,0.01842738,-0.0115491245,-1.596524e-33,0.07269967,-0.06712499,0.09397595,-0.07664448,-0.056767985,0.10578386,0.013826928,-0.040298905,-0.046016395,0.05212158,0.050816327,0.038951878,0.05826682,-0.014711226,-0.058936644,-0.033386774,0.061260562,0.055519477,-0.0472068,-0.013287331,0.0076743886,0.08872642,0.01456243,0.049221255,-0.009430789,-0.0080171265,0.0946296,0.05656922,0.013479586,0.0041567245,0.053279243,0.0689904,-0.05754101,-0.056178752,-0.034315586,-0.0047383206,-0.024616744,-0.025488798,-0.00019047777,0.06355313,-0.094925635,0.056896806,0.035119325,-0.022489268,0.01870792,0.01925792,-0.10147704,-0.020763984,-0.05560073,0.056345016,0.055604976,0.02134254,-0.027827846,-0.008167027,0.0030168048,0.030034738,-0.04492967,0.017936062,0.0006236986,-0.04472276,-0.039958883,-0.0032765763,-0.017846499,-5.186893e-05,0.008808949,0.08849033,-0.029788468,-0.013927248,0.08139273,0.015894143,0.06533616,0.042152893,-0.030093292,0.10773165,0.0048662485,0.03904551,0.0069524897,-0.081346445,0.041793287,-0.009417966,0.05765417,-0.016200695,0.0031399333,-0.08137572,-0.068812,-0.03842402,-0.010935644,0.07600206,0.07321456,-0.018961934,0.015376679,-0.010597529,-0.031051299,0.02699544,0.04404913,-2.8526312e-08,-0.0114840465,-0.039220627,0.001648291,0.02150617,-0.026157508,-0.035398036,-0.0015049143,-0.0053296834,0.024998818,-0.09147489,0.037318185,0.018927867,-0.017940134,0.03254596,-0.007696605,0.027777936,0.04157088,0.082698084,-0.0060525,-0.011359828,-0.09210311,-0.017715642,-0.076586656,0.07491516,0.0022105242,-0.11158276,-0.0038123194,0.0067590717,0.04871265,0.01762528,0.036233455,0.023369553,-0.097141296,-0.065578744,-0.028153954,0.06141143,-0.070184335,-0.0527993,0.008178652,0.046902418,0.077452146,-0.11791165,-0.014461228,-0.026538823,-0.03312685,0.0032454978,0.016454909,-0.025470072,0.00380634,-0.05288697,0.037069783,0.044148315,-0.003596815,-0.11457932,-0.11986603,-0.011262752,0.005578904,-0.05660204,-0.02259719,-0.10564291,0.022888724,-0.024588391,0.20853144,0.008846906 +1.14.14.193,A cytochrome-P-450 (heme thiolate) enzyme isolated from the plant Taxus x media. The penultimate step in paclitaxel (taxol) biosynthesis.,384,0.99999994,-0.03099242,0.04343538,-0.07982251,-0.025133861,0.024404936,0.070928685,0.0119342925,0.075096704,0.029511668,0.033787686,0.023234954,0.004184811,-0.05113429,-0.060892228,-0.015925596,-0.014242354,-0.06350677,-0.00029826086,-0.0023988073,-0.048044764,0.08933077,0.03687144,0.04336554,0.06289598,-0.006164742,-0.0287066,-0.024817383,0.04372542,-0.01810303,-0.079959035,-0.010897118,0.000729622,0.0041927304,-0.024321439,0.028732235,0.069520175,-0.045841817,-0.019380186,0.035127915,-0.02172076,0.06756935,-0.059215274,-0.11232197,0.00075729797,-0.11339136,-0.072819285,0.018472897,-0.031492237,0.064626426,0.030293014,-0.014907449,-0.036626417,-0.035423063,0.023237566,-0.013828764,-0.019442843,0.032811083,0.031071074,-0.006129882,-0.022285474,-0.023185313,0.03842817,-0.022501267,0.036489636,-0.030309608,0.0076373364,-0.042617016,-0.00017723413,0.010981073,-0.08523908,-0.06292758,-0.060694408,0.005344343,0.01912947,-0.09022784,0.048664786,0.027709337,0.02864614,0.026823392,-0.05414613,0.04958208,0.041904587,-0.0072626746,0.11876419,0.009694763,0.022399686,0.06555587,0.07192014,0.076023914,-0.03254657,0.010456817,0.08527595,-0.012966479,-0.00765007,-0.040664285,0.018652346,0.07832256,-0.022474503,0.020620555,-0.01348654,0.093624085,0.039379198,0.017677698,-0.14798146,-0.07607114,0.014829786,-0.10094883,0.02935407,0.038893994,-0.07082281,-0.05913593,-0.007867697,-0.037712038,0.02093044,-0.02033658,0.11514331,-0.021643123,-0.09508519,-0.056930985,-0.11043207,-0.025343454,-0.06628744,0.027133457,0.0049097505,0.009312111,0.00723346,-0.037761845,2.2025582e-34,0.04755178,0.042803638,-0.01863738,-0.025360253,0.03935139,-0.015514935,-0.020215673,0.03448488,-0.1220709,0.02369439,-0.113845564,-0.08177324,-0.050968006,-0.06196938,0.008793855,-0.014816272,-0.042461395,0.027364595,0.038487036,0.0094771935,-0.01662207,0.05479569,-0.033299267,-0.02334465,-0.04347618,0.09805396,-0.027137658,-0.042305388,0.037597172,-0.008795113,-0.035592094,-0.08192067,0.002220553,-0.029136369,0.026218988,0.006764831,-0.021910988,-0.014342624,-0.04169761,0.05378514,0.03621491,0.031040702,0.12411674,-0.08018918,0.021116745,-0.012330497,-0.090956435,0.011580154,0.061063934,0.04141965,0.0048331954,-0.016432967,0.13308677,0.033127774,-0.06515327,0.028856691,-0.040250707,0.047863394,0.01747453,0.03871197,0.12846369,0.046622325,-0.028016042,0.079628296,0.012691473,0.07039103,-0.08115118,-0.010171896,0.021966388,0.11845237,-0.08465327,-0.0078004273,0.020480067,-0.06579286,0.10278234,-0.017553188,-0.0059788693,0.025681382,-0.011607989,0.06491278,-0.014900807,0.022389904,-0.027122054,0.018636707,-0.013666031,-0.024303729,0.021757813,0.088131666,-0.076734975,0.038531523,0.027425468,-0.07097496,-0.00037080288,0.01328576,-0.0011641792,-1.317071e-33,0.06528363,-0.061079316,0.09014701,-0.09289283,-0.053369585,0.11776658,0.006307204,-0.032075174,-0.0415147,0.052596923,0.060413145,0.021981454,0.030527178,-0.028062025,-0.07696186,-0.025398739,0.049772125,0.055179954,-0.04215993,0.017662294,-0.01635608,0.07397487,0.014854315,0.0510959,-0.009705752,-0.020360926,0.08352175,0.053818837,0.025347177,-0.0064625833,0.02293739,0.054405387,-0.066295244,-0.048763067,-0.022686172,0.0052982625,-0.029563284,-0.01720246,0.03764652,0.06493035,-0.07694895,0.050070465,0.05195441,0.017545704,0.033038538,0.023156753,-0.11349514,-0.02898593,-0.07069478,0.05188661,0.0552287,0.012755439,-0.05376675,0.009312068,0.013339225,0.035585392,-0.03228772,0.041617107,-0.010133669,-0.062113002,-0.036686476,-0.019725611,-0.035962593,0.030978601,0.0037990876,0.100645185,-0.029495455,0.01229814,0.025143836,0.025643544,0.07187945,0.028956944,-0.033454157,0.08957209,0.017079506,0.025003774,-0.0015506401,-0.058277003,0.0439132,-0.019329919,0.05219035,-0.016973102,-0.004868331,-0.09645472,-0.03172447,-0.046331506,0.0005691712,0.06826236,0.050495464,-0.030625211,0.011262298,-0.018410474,-0.027031494,0.037369486,0.060797352,-2.8131778e-08,-0.020232959,-0.06613203,0.010414688,0.011498813,-0.021684233,-0.036860265,0.00069852767,-0.0034112853,0.049332872,-0.06359573,0.02804174,0.019496134,-0.008030573,0.03418044,0.008327198,0.029097492,0.022709684,0.0961712,0.0013695933,0.011836387,-0.09646659,-0.0074057365,-0.06239225,0.048216365,0.043268215,-0.09866474,0.020589251,-0.020998484,0.06350651,0.011371616,0.027949935,0.02960779,-0.09207584,-0.038208656,-0.015885668,0.07252361,-0.05470146,-0.03513599,0.014393229,0.018727252,0.03121232,-0.11220672,-0.02788452,-0.028517192,-0.042141534,0.0060097026,0.03353703,-0.014675395,-0.01481709,-0.032822832,0.005246598,0.04790818,0.009031914,-0.14771824,-0.105126545,-0.015911758,0.036932677,-0.061657656,-0.028990837,-0.10634131,0.034082495,-0.011342097,0.19918121,0.013208146 +1.14.14.194,"A cytochrome P450 (heme thiolate) enzyme that has been isolated from the plants Atropa belladonna, Erythroxylum novogranatense and Anisodus acutangulus. It participates in biosynthesis of assorted tropane alkaloids.",384,1.0,-0.11574897,0.0068495194,-0.10572589,0.0015957016,-0.017313637,0.064430825,-0.0720722,0.048984073,0.013048181,-0.013565395,0.037215408,-0.023845447,-0.03587502,-0.044808213,-0.0652106,0.05525819,-0.03493206,-0.008863238,0.024489274,-0.08935144,-0.0077091707,0.0900095,0.02465057,0.051977437,0.033628996,-0.021417145,-0.0074530686,0.02073473,-0.032259922,-0.060215514,-0.05804145,-0.018424172,0.0444126,0.010094436,0.0146107115,0.1137593,-0.09584261,-0.022954494,0.040358853,0.006292664,0.067718476,-0.05221299,-0.09186008,0.020649957,-0.054915547,-0.057846658,-0.012770335,0.018540943,-0.02203351,-0.019679535,-0.0063015027,-0.03350271,-0.029111167,-0.0032849633,-0.07203508,-0.019489499,0.029980399,0.007848776,-0.036749624,0.018027786,0.0479691,0.066157416,-0.057281427,0.005108964,-0.017820423,-0.042694762,-0.015540523,0.022618234,0.02910672,-0.09702903,-0.0098497905,-0.08837645,-0.034958232,0.06275032,-0.043587483,0.044119097,-0.023342855,0.002612646,-0.032588713,0.017468924,0.0656562,0.014110059,-0.010364548,0.10495146,0.056254774,-0.028714154,-0.045578886,0.11600583,-0.016451726,-0.020936327,0.04629004,0.045940068,-0.028449083,-0.044108767,-0.0618128,0.07526936,0.04312087,-0.012004642,0.015512771,-0.033790648,0.04553535,0.03883598,-0.01775747,-0.057142388,-0.044912413,-0.027969312,-0.01622842,-0.031564046,0.090721406,-0.07452786,-0.010297865,-0.040039543,-0.04068815,-0.0434574,0.0033481035,0.08293221,-0.005152123,-0.06356572,-0.004569012,-0.03611439,-0.07627389,-0.0012806415,0.020149311,0.052606974,-0.002499525,0.0067623425,-0.11732177,6.208032e-33,0.09005092,0.067179866,-0.035741277,0.04017576,0.018104892,0.032135565,-0.060054958,0.0012553554,-0.08575003,0.02193881,-0.12798116,-0.047745902,-0.012088739,-0.059750386,0.025898155,0.011832616,-0.039952934,0.040352274,0.08711611,-0.03132319,-0.033289358,0.010693445,-0.07304418,-0.0031164857,-0.01832595,0.09358112,-0.027650619,-0.006586922,0.035627272,-0.015808854,0.015131707,-0.08359976,-0.03422792,-0.04485028,0.022576693,-0.044161785,-0.07508499,0.03447453,-0.07907337,0.058923785,-0.025632583,0.060193922,0.06189497,-0.070565216,0.051369675,-0.01769179,-0.092200466,0.02077034,0.054196406,0.054348916,0.046457388,-0.033840742,0.11247831,0.040795926,-0.059368357,0.0455866,0.009386927,0.07508817,0.045983594,0.07572494,0.12690368,0.05335732,-0.042236283,0.049595665,0.045226455,0.041193016,-0.03076222,-0.023092283,-0.046241682,0.15174988,-0.068189785,-0.033841144,0.054773215,-0.011525566,0.057169627,-0.0014694276,-0.012699243,0.042467684,0.0070364974,-0.008059529,0.014697478,-0.04780937,0.014787146,0.02190291,0.014865826,-0.020112092,0.036599863,0.035529118,-0.015700974,0.0673951,0.046477992,-0.04529473,-0.020634629,0.0065231044,0.015518253,-5.7892623e-33,0.07346201,-0.058532193,0.000535049,-0.1176577,-0.036022663,0.09141136,-0.01304044,0.015623554,-0.032245837,0.079434104,0.12147233,0.023013862,0.03519917,0.0028662765,0.0060424237,-0.031899735,0.003924574,0.06272559,-0.00574507,0.051557425,-0.05037361,0.021984145,-0.009137658,-0.017357575,-0.016415393,0.021166183,0.051903732,0.004084291,0.03091091,-0.001427405,-0.037263382,0.034471687,-0.08235315,-0.07174655,-0.05645994,0.041556466,-0.010299499,0.0030325628,0.019619545,0.05251075,0.018597137,0.056594774,0.010141738,0.08765269,0.0359208,0.04595687,-0.11255906,-0.024281196,-0.06931731,-0.025367621,0.073117174,0.042702347,0.03042029,0.019061591,0.024688674,-0.044793054,-0.027055688,0.025064379,-0.01847406,-0.07546847,-0.035273436,-0.029968457,-0.044390835,0.024552064,0.0137378415,0.09620508,-0.07502827,0.06939856,-0.040733315,0.035805322,0.034994766,0.013880928,-0.024630513,0.050901428,-0.004871183,-0.04038315,0.014389451,-0.03633548,0.06256661,0.0083892085,0.05854988,-0.0036016842,-0.01266942,-0.07413353,-0.02542922,-0.095388904,-0.01596294,0.12920295,0.059569187,0.009391135,0.024667125,0.06519666,-0.06534497,0.040762518,0.044338126,-3.799962e-08,-0.008715079,-0.07159425,-0.0032489095,-0.015743952,0.009339402,-0.016287398,0.03074795,0.0071132765,0.032263245,-0.0123858815,-0.024019567,0.036663245,-0.030090904,0.0055494434,0.055440143,0.03974092,-0.0028525563,0.035423193,0.03279595,0.058459632,-0.05940121,0.07376748,-0.06607116,-0.008928149,0.057373594,-0.08457253,-0.01016934,-0.026972136,0.061779372,-0.0065554725,0.06703598,0.029704396,-0.024656726,0.011837518,-0.04350131,0.004064749,-0.038377065,-0.062555306,-0.028929189,-0.031166166,-0.045733847,-0.050921608,-0.07269566,-0.009601523,-0.05865006,-0.0052579,0.05262144,-0.016437031,0.042308733,-0.0140697155,-0.0591548,-0.022710154,0.079404116,-0.1223166,-0.08514331,-0.03802295,0.07660903,-0.08578452,-0.07481187,-0.10643894,0.04634012,-0.018037086,0.20970424,0.006817604 +1.14.14.195,"Isolated from the plants Hyoscyamus niger (black henbane) and Anisodus acutangulus. Involved in the biosynthesis of the alkaloids hyoscyamine (atropine) and scopalamine. The reaction involves hydroxylation of littorine, giving a 1,2-diol that undergoes a spontaneous dehydration accompanied by pinacol rearrangement.",384,1.0,-0.049285665,-0.036869027,-0.12632696,0.053599395,-0.00027551941,0.07782871,-0.044596866,-0.011420011,-0.017748622,-0.035630383,0.06378107,-0.070176825,-0.018338155,-0.07245123,-0.11944686,0.048067313,-0.07993467,-0.012741345,0.061745267,-0.05134901,0.058377318,0.063691705,0.0008295411,0.02012145,0.045616284,-0.018790022,-0.048882205,-0.008234363,0.017552841,-0.068426624,0.045275856,0.014583791,-0.0124040935,-0.034817617,0.037002586,0.081976615,-0.0880602,-0.04797881,0.052658465,0.038649976,0.020380966,0.017190045,-0.031453215,-0.006492773,-0.045759976,-0.030670691,-0.03655794,0.03532639,-0.01847176,-0.024972318,-0.025865173,-0.04641918,0.0059232335,0.08402056,-0.010863613,-0.016059797,-0.014237985,0.029779634,0.014609139,0.018118752,0.01935705,0.072974555,-0.019960353,-0.03527776,-0.052432314,-0.026897851,-0.009427387,0.010299255,0.12072354,-0.036471296,0.028787274,-0.069912195,0.100001305,0.005440723,-0.03405403,0.011953444,-0.04885606,-0.033937372,-0.09005862,-0.011449773,0.024319373,0.025374448,0.063043825,0.08748198,-0.021581592,-0.014732153,0.003273847,0.0702826,0.039882466,-0.018358061,0.045698024,0.06488072,-0.0061128773,-0.055966232,-0.030063407,0.022726607,0.07876959,0.0062676314,0.0075501674,-0.04511813,0.054334868,-0.03514602,-0.06817498,-0.064115256,0.033416823,0.04863026,-0.041860864,-0.052828662,0.067694694,0.002519525,-0.005286004,0.01311372,-0.05740707,-0.013275442,-0.057439964,0.022469139,0.011567907,-0.0630806,-0.09201659,-0.030037155,-0.014598412,-0.031404477,0.022480503,-0.006216386,-0.038436998,-0.004088808,-0.09754712,4.5725243e-33,0.04430406,0.015144136,-0.082623765,0.008777639,0.03156616,-0.08536947,-0.05976254,-0.014766334,-0.031750843,-0.022154063,-0.15278545,-0.0016721087,-0.02021063,0.0040696887,-0.030882794,-0.078937605,0.012802756,0.0042290273,0.112504214,-0.021589397,-0.047350094,0.1025552,-0.09458769,-0.0107475845,-0.087302856,0.019019285,-0.030412754,-0.028480275,0.035497777,0.0010730919,0.059513472,-0.112059794,-0.019289466,0.006376032,0.052171793,0.02230426,-0.05373307,-0.013108043,-0.04841461,0.06372451,0.056758504,0.09097432,0.05773928,0.019585216,0.083481826,0.09678062,-0.054842107,0.032993954,0.048239175,-0.0029181459,-0.020367416,-0.027080676,0.09853479,-0.016972942,-0.07350294,-0.0018631652,-0.0042730793,-0.0032662628,0.092192836,0.09781643,-0.04600942,0.011808596,-0.023173781,-0.000510659,0.034639705,-0.022505987,-0.087178476,-0.017855342,-0.045443594,-0.061577287,-0.10140051,-0.041037522,0.03235381,0.014516153,-0.00723797,0.022025866,0.044443037,0.003014903,-0.03037692,1.2880055e-06,0.016850227,-0.025987817,0.023073431,0.02817347,0.007231434,-0.0004026899,-0.050848443,0.056728184,-0.010580413,0.052769925,-0.011374988,0.028355164,-0.040177137,-0.010929957,0.06963337,-4.7694798e-33,0.020037524,-0.0468674,-0.0044560805,-0.046490666,-0.021256864,0.11826171,-0.03522354,0.06554713,0.009554646,0.05190129,0.06164564,0.030047486,0.0021091036,-0.028399004,-0.063843206,0.003899812,0.055546414,0.17182991,-0.0433679,0.026658462,-0.09156311,0.065496564,-0.050837997,-0.012661508,-0.047480598,0.083983846,0.08924472,-0.054682527,-0.00050366565,0.08027788,0.07035127,-0.032138076,-0.094990626,-0.048230764,0.0024242802,0.042687114,-0.05187537,-0.038158033,-0.021055127,0.06986333,0.038782943,0.04308838,0.0676086,0.02762125,0.08900763,0.02555333,-0.11373499,0.0010430812,-0.04873333,-0.028778011,0.06467994,-0.0118781775,0.04554107,-0.036689036,0.070494875,-0.098555826,0.051266197,0.0025858071,0.031191388,-0.041234847,-0.002655786,0.0041469815,-0.0150534725,-0.031884577,0.03331072,0.0934143,0.00015560866,0.031520016,0.021498566,-0.06906002,0.047867667,0.017439658,0.00071650144,0.044074044,0.0048704166,-0.00045567963,-0.055437375,-0.13257593,-0.010722356,-0.026878996,0.066939175,0.03236671,0.09168815,-0.06468142,-0.0009836172,-0.04935542,0.038073417,0.0415508,0.03669594,-0.012560783,0.0743614,0.029796308,-0.050292734,0.056160673,0.10678953,-4.1178676e-08,-0.01692534,-0.010529239,0.029562267,0.030207526,0.001961815,0.028178558,0.03310458,0.02040967,0.080077164,-0.040918674,-0.06480916,0.038626086,0.035132214,0.03686957,0.015051722,0.023997467,0.02005433,0.036928177,-0.001877546,0.053336006,-0.08257221,0.004632505,0.0354769,-0.005132846,0.021361496,-0.08650538,0.048588816,-0.015582069,0.08570606,-0.017989654,0.054757535,0.05006816,-0.050211884,-0.0022184663,0.0116540445,-0.0173454,-0.019915203,-0.007277448,0.0069089434,-0.019610703,-0.049612347,-0.03578627,-0.012437507,0.00042520554,-0.05791292,-0.021530047,-0.018815553,0.04243672,0.017056227,0.0283297,0.043062057,-0.032387085,0.04992399,-0.061531764,-0.089778,-0.14860633,0.0066506607,-0.057719868,0.005031751,-0.14722145,-0.006021913,0.020999933,0.10764459,0.06269962 +1.14.18.13,"A group of coupled binuclear copper enzymes found in filamentous fungi. Unlike EC 1.14.18.1, tyrosinase, these enzymes exhibit a distinct preference for ortho-methoxylated phenolic compounds such as guaiacyl- and syringyl-type phenolics derived from lignin depolymerization. When acting on syringyl-type substrates (having two ortho-methoxy groups), but not on guaiacyl-type substrates (a single ortho-methoxy group), the enzyme catalyses oxidative demethoxylation releasing methanol. The enzymes accommodate a wide range of methoxylated phenolic substrates, with variability in the para-position substituent relative to the phenolic hydroxyl.",384,1.0,-0.03259415,-0.085153826,-0.02274187,-0.006668395,0.116131365,0.033899955,-0.030348841,-0.00822275,0.055489916,-0.009307667,0.106125884,-0.056851353,-0.089724004,-0.013384156,-0.058485854,0.04981644,-0.06443933,0.038894325,-0.036859244,0.0051442212,0.061627347,-0.011212964,-0.019385202,0.016588977,-0.006963291,-0.028634876,0.02118132,-0.030542795,-0.042941984,-0.07611245,-0.004197096,0.021698603,0.0030314466,0.027690351,-0.004370859,0.083053894,-0.026397802,-0.009847572,-0.0005368533,-0.025361856,-0.016900202,-0.048247658,0.0050441,-0.014500896,-0.050274916,-0.10688307,0.028629791,0.026469247,0.002405142,-0.070148684,-0.032463968,-0.0008185498,0.008920413,-0.005811337,0.030905316,0.10785621,0.029266521,-0.053483084,-0.052751657,0.061287716,0.009872651,-0.05471751,-0.02559739,-0.020650592,-0.10606441,0.04561185,0.008449581,-0.009934551,0.020233266,-0.0442436,-0.09079386,-0.0116484,-0.0746946,-0.06554076,-0.0020210806,0.12684064,0.09803437,-0.066193506,0.030569723,-0.04574751,0.0303429,0.096931815,-0.0061389892,-0.04364931,0.086396165,-0.046088137,0.042686123,0.017708188,0.04986818,0.017169679,0.06820788,0.0578977,-0.052844122,-0.028764216,-0.06484396,0.015238004,0.112455666,0.08871293,0.020053277,-0.016364958,0.043753564,0.01927135,0.036071837,-0.08974849,-0.0772105,-0.007295831,-0.019963427,0.03414975,0.09664483,0.07966691,0.040916927,0.037348337,0.03132561,0.030239256,-0.036741547,0.05918944,-0.0025867987,-0.012192176,-0.038603485,-0.045599476,-0.011727659,0.0012768266,0.027513191,-0.06879201,0.0155724725,0.0033860756,0.007931667,7.234457e-33,0.09325164,0.0393966,-0.08274788,-0.0003884179,0.110845506,-0.010199761,-0.09710036,0.07435526,-0.010680342,0.011263605,-0.09461418,-0.020103795,-0.08122075,0.048963796,-0.010071097,-0.02751942,-0.046173163,-0.016380029,-0.014533979,0.039173357,-0.0087899435,0.020964162,-0.105440795,0.016529405,-0.020510804,-0.035577036,-0.036974978,-0.0056701987,0.0011493716,-0.016829815,0.015364669,-0.08181536,0.0177397,0.0016070035,0.026925499,0.03370733,-0.00012114685,-0.0056656906,0.0443224,-0.016057618,0.007080269,0.07139819,0.04083661,0.009009246,0.02368183,-0.04745569,-0.085155606,0.12695262,-0.026347844,0.012270064,0.016674206,-0.020451218,0.09203977,0.05291524,0.029306939,-0.025307149,-0.08774163,-0.045033205,0.073981,0.021223055,0.032120492,0.053253558,-0.011037299,-0.03336942,-0.006342264,-0.022738222,-0.015682269,0.01851746,0.035312835,0.04335145,-0.026404386,0.024928933,-0.042740382,0.03485613,0.028030097,-0.038018316,-0.052901812,-0.021455392,0.11608624,0.05268369,-0.021780197,0.030832017,0.031723924,-0.036125816,-0.060864277,0.04268284,-0.07493471,0.034296405,0.009289978,-0.04947016,-0.01857518,-0.0022737025,0.008705958,-0.020151464,0.037340187,-6.967418e-33,0.09755669,-0.08795529,0.055189457,-0.053340472,-0.006323162,0.02381205,-0.04091874,-0.037268423,0.03672004,-0.07233716,0.07627002,0.006681409,0.030019034,-0.055569258,0.071345456,-0.051121667,-0.02726795,0.15473728,-0.061368957,0.025341196,-0.04522254,0.04952595,-0.043705195,-0.022954268,0.09013296,-0.033198103,-0.06022452,0.009018394,0.038673617,0.07033731,-0.0027578003,0.023077995,-0.017273743,-0.0025348568,-0.014387506,0.041220453,-0.084675714,-0.017905345,0.032226402,0.12268695,0.005631389,0.031077668,-0.02009723,0.017544284,-0.022759724,0.10853673,-0.1534036,-0.05068588,-0.0030185885,-0.005551371,0.01400724,0.06484303,-0.09596078,-0.03758448,0.015640805,0.067845225,-0.007100947,-0.08765417,-0.050028145,-0.050655037,-0.09140208,-0.037441403,0.014662973,-0.03530033,-0.0074703344,0.083785556,-0.010545026,0.11099059,0.02395178,-0.07626667,0.029106816,0.053746495,0.00811397,0.015047466,-0.012030289,-0.034381207,-0.068893984,-0.012334826,0.025213333,-0.027108816,0.067881115,-0.004713036,0.027224043,-0.06433601,-0.06449157,-0.060741186,0.021949548,-0.0005144753,-0.042032223,-0.00028501364,-0.02523414,-0.009016004,-0.015241554,0.1125593,0.06390247,-4.8005273e-08,-0.015832445,-0.0050322223,0.06385389,-0.050558873,-0.02665298,0.023250954,0.088416144,0.057837933,0.021639263,-0.013026006,-0.051248483,0.08749188,-0.067433566,0.035346005,0.018179648,0.034309547,-0.011535996,0.008306536,-0.031053456,0.019921592,0.01276351,0.015532502,-0.11366068,0.022952642,-0.033792734,-0.050050545,0.017826673,0.052823123,-0.024177162,-0.005076733,0.04515103,0.053829905,-0.0061606313,0.031319205,-0.045952182,0.023676094,-0.06764177,-0.024445068,-0.012008656,0.036848523,-0.014640368,-0.097299375,-0.08829744,-0.005807337,1.1786712e-05,-0.061687857,0.009573045,0.081983484,0.022964062,0.076115616,0.068440706,0.057476148,0.065408766,-0.055077776,-0.060600094,0.0037622713,0.051216614,0.0026834563,-0.042216722,-0.070683956,-0.0057711843,-0.050013315,0.16924764,-0.016667116 +1.16.2.1,"The MtrC and OmcA proteins of the bacterium Shewanella oneidensis MR-1 are decaheme c-type cytochromes that reduce iron oxides extracellularly, passing the electrons to MtrA, another decaheme c-type cytochrome located in the 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+1.17.98.5,"The enzyme, originally characterized from the acetogenic bacterium Acetobacterium woodii, catalyses the reduction of CO2 to formate with electrons provided by the oxidation of molecular hydrogen. It consists of two catalytic subunits - a hydrogenase and a formate dehydrogenase, which are connected by two types of electron transfer subunits. The enzyme forms membrane-anchored nanowires in which the electron-transfer subunits oligomerize through their C-terminal helices to form the backbone of the filament. The rapid electron transfer via the filaments enhances the activity of the enzyme, resulting in a very high catalytic turnover rate. While the reaction is similar to that catalysed by the formate hydrogenlyase complex, which is formed by EC 1.17.98.4, formate dehydrogenase (hydrogenase), and EC 1.12.7.2, ferredoxin hydrogenase, this enzyme is not biased towards formate oxidation, and does not require ferredoxin in order to complete the reaction (although it is able to use reduced ferredoxin instead of dihydrogen for the reduction of CO2). 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+2.1.1.400,"The enzyme, characterized from the archaeon Methanococcus maripaludis, participates in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor of EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase (also known as [Fe]-hydrogenase).",384,1.0,-0.024802819,-0.03007961,-0.15394409,0.03174384,0.090988256,0.04642022,-0.06444202,0.014234125,-0.015185672,-0.112532414,-0.0290979,-0.06896491,-0.0880511,-0.015681555,-0.098122925,-0.032050826,-0.06594616,-0.030564714,0.040037468,-0.017302617,0.042460248,0.03536985,0.01515342,-0.034093324,-0.024948094,0.012145216,0.020047253,-0.02834517,-0.015526763,-0.00060311536,-0.022903299,-0.02499207,0.10625046,-0.05372497,0.05662099,0.11765616,0.01394715,-0.05615702,0.0509354,0.033161506,0.049621753,-0.020667898,0.010674278,-0.036574423,-0.044448048,-0.035013575,0.06740023,0.009797367,0.014801374,0.008042407,-0.07387619,-0.01254357,-0.046335272,0.012200897,0.025654787,0.01796506,0.032752838,-0.062096212,0.01719047,-0.03440635,0.052072726,0.008468619,0.009442399,0.011518419,-0.02570137,-0.052200884,0.06841588,-0.08137761,0.07712951,-0.09453879,-0.058419723,0.028696954,-0.11245748,-0.07653138,-0.08927764,0.031101573,-0.013166129,-0.085256584,0.08931533,-0.018715052,0.024140067,0.029154,0.011936592,-0.03251988,0.061300382,-0.013089481,0.015293305,-0.01565087,-0.0024703918,-0.0015499619,0.024157953,-0.05782975,0.005176704,-0.037396915,-0.07906165,0.043518722,0.05819145,0.05187348,0.017436748,0.0082194405,-0.056397058,0.03815452,-0.022086238,-0.056359068,-0.07517168,-0.009934239,-0.023656154,0.15015653,0.05712758,0.05992219,0.031813767,-0.016162602,0.04705885,0.03308559,-0.0047035553,0.06468764,0.03439716,-0.064319864,-0.045137957,0.074288204,0.056453057,-0.005852699,0.058339514,0.02672427,0.005895184,0.024446167,-0.12297418,2.7873735e-33,0.0858775,0.039625593,0.024829824,-0.06566575,0.029658562,-0.011044032,-0.12096871,0.019127911,-0.011565438,-0.008860433,-0.021440094,-0.019333474,0.07055273,-0.061139308,-0.09859499,-0.010559059,0.003283106,-0.036966518,0.03196447,-0.0066427873,-0.03593852,0.08529399,-0.01975571,0.005210371,0.001294273,0.053341668,-0.044449396,0.017752012,0.04984598,0.022160776,-0.0029102766,-0.13245335,-0.084080845,0.04203854,0.11118742,-0.030397663,0.008147036,-0.08937982,-0.028371584,-0.062144525,0.0013572427,0.036025684,0.014163615,-0.06615829,0.053142935,-0.020426469,-0.0319453,0.09233527,0.007964126,0.086573035,-0.034751903,-0.0052903276,0.07553757,-0.029229457,-0.09161728,-0.0045480197,-0.02678657,0.01058959,0.051727995,0.097859,-0.041191764,0.07063171,0.027626872,0.07047548,-0.012553602,-0.023602512,-0.015901295,0.024463316,0.0831318,0.121273965,-0.04964993,0.009533748,0.022976128,0.056675058,0.025566649,-0.066789806,0.01625254,-0.07287948,0.051045846,0.015808733,0.0089601185,0.016477618,0.05083925,-0.031502645,-0.051251628,0.031846933,-0.100189544,-0.007246,-0.0061534494,0.025517555,-0.012517235,0.0038996954,-0.018770488,0.044318512,-0.014182135,-3.1133963e-33,0.0575912,-0.10147267,0.045383416,-0.113061175,-0.08758374,0.059374735,0.011421342,-0.021562813,-0.017348219,-0.021896591,0.10972505,-0.044420388,0.04534495,-0.091429695,0.041053373,0.011618471,0.06376608,0.069470875,0.027131757,0.023861233,0.044283632,0.021818057,-0.041580137,-0.026296409,0.027285928,-0.01375138,-0.0076642954,0.021078898,0.043104667,0.05126286,0.017194448,-0.025100557,-0.05398509,-0.092630185,-0.0775238,-0.02701982,0.012865382,0.022773482,0.026819931,-0.0023352047,0.044677485,0.02137126,0.037557963,0.08137671,0.048706193,0.08248806,-0.06545544,0.02748412,0.02003474,-0.018993719,-0.025414659,-0.04492998,-0.06359593,0.006915918,-0.00065456197,-0.007481158,0.10494912,0.04988204,-0.054463647,0.040202007,-0.02490924,-0.042409625,0.05750487,0.03552227,0.07098318,0.07234785,0.004236144,0.0755307,0.054260638,0.016060535,0.08217148,0.048213713,0.0061256574,0.023593714,-0.043542147,-0.036248595,-0.026165364,-0.04137326,0.01792093,-0.02371306,0.05507142,-0.0011048762,0.0030719605,-0.06500052,-0.020583093,-0.10090286,0.062733136,0.083605185,-0.017786622,0.030055914,-0.0441336,-0.005590582,-0.07309528,-0.015257102,-0.004521224,-3.694112e-08,-0.029594908,-0.037639063,0.06948934,-0.07548317,0.023428157,0.044243194,0.043200634,-0.038147327,0.014586968,-0.034048498,0.042446204,0.042571206,0.032440245,-0.027367488,0.0039068446,-0.0054978556,-0.018183066,0.038213234,-0.009017513,0.068062134,-0.013775441,-0.009429829,-0.06649722,0.030954743,-0.050605662,-0.10302534,0.03381343,0.069780335,-0.02877059,-0.04688194,-0.052864812,0.039360557,0.00023209867,0.0059853178,-0.11420825,-0.03477203,-0.05189222,-0.03286948,-0.08386553,-0.0035131264,0.0012149153,0.018842058,-0.035625268,-0.011103376,0.011635323,-0.0085500805,0.0041111046,0.019470906,0.011471083,0.03252062,0.075362265,-0.0036733532,0.07674735,-0.07222562,-0.05302866,0.018145155,0.03374759,-0.08695451,-0.02536701,0.0003203082,0.06569861,-0.04065195,0.1558909,-0.008695625 +2.1.1.401,"The enzyme has been charcterized from the plant Arabidopsis thaliana. The product, methyl nicotinate, is involved in the transport of nicotinate to different parts of the plant.",384,1.0,-0.01885493,-0.007017622,-0.079899184,-0.005937881,0.04025899,0.09162664,0.0010179619,0.036623657,0.0135212215,-0.006472016,0.06756885,-0.008184309,-0.10785369,-0.035891097,-0.020805784,-0.00027066626,-0.04600708,0.07518741,-0.06831439,-0.05600547,0.09853429,0.04697076,-0.04012075,-0.03330416,0.0013688629,0.003181135,-0.052115764,-0.050112523,0.0333863,-0.07889985,-0.07852559,0.005427953,-0.014616923,-0.013486222,0.0146990055,0.061892044,-0.01722558,-0.08752993,0.0017932839,-0.0005949081,0.090418406,0.0034189024,-0.08162775,0.023620512,-0.11443149,0.034079295,0.071585685,-0.0249575,-0.031764857,-0.021699985,-0.10645221,-0.03331597,-0.014224959,-0.02367635,-0.026733862,0.024897538,0.026624335,0.0098874215,-0.0025523081,0.007900334,0.026828974,0.022425482,0.019777235,-0.023878524,0.01811359,-0.0913357,0.028117735,-0.015767101,0.050311927,-0.099775605,-0.030685907,-0.06791615,-0.039579738,-0.0031688844,0.002740358,0.090691134,-0.024136465,0.0042790044,0.058789805,0.0024125886,0.074082226,-0.0027535693,0.009502039,0.07911924,0.041112892,0.03154682,-0.02479719,0.06787593,0.06325296,0.011990917,0.020033788,0.039359216,-0.06453383,0.0036550066,-0.14465174,0.028488277,0.059360772,-0.007083373,0.0226068,0.003926658,0.028942648,0.05000928,-0.018258093,-0.10996804,-0.04869975,0.011765377,-0.039981782,0.018306188,-0.0018983795,0.022340339,-0.016329618,0.043591384,-0.025487421,-9.3626855e-05,0.0057896567,0.077093095,-0.020279089,-0.03417337,-0.02903535,-0.01795847,-0.04851103,-0.013744662,0.06739638,0.028194966,-0.06817217,0.00890328,-0.14022768,-6.896888e-34,-0.0044200667,0.058937393,-0.025266038,-0.015500543,-0.0026608314,-0.02885195,-0.023509098,0.06542915,-0.025958851,-0.079957545,-0.05764942,-0.13430399,-0.027076699,0.0179362,-0.054296594,-0.0019276505,-0.058773793,-0.088051915,0.031275395,-0.028315743,0.02462004,0.037165314,-0.07912165,0.022193538,-0.046711348,0.0057856757,-0.03965539,-0.0050680037,0.049420908,-0.029104382,0.035358775,-0.06690952,-0.066533,-0.061769404,0.106920056,0.028428556,0.0035190855,-0.014969693,-0.07431173,0.0247335,0.052485175,0.042018797,0.081126,-0.022837423,0.02830161,-0.00093130604,-0.12065462,0.037260536,0.11778971,0.009695298,-0.011210198,-0.03234603,0.1293615,-0.051988665,-0.052502204,0.03245909,0.010659464,0.008768281,-0.05759277,0.0392858,-0.06608299,0.022428075,0.039828695,0.060895596,0.01506992,0.0387124,-0.10095976,-0.081691846,0.018974846,0.043073054,-0.039248005,-0.03581623,0.0421356,-0.032389265,0.010857125,-0.058287036,-0.058559176,0.010282222,-0.024774611,0.016302925,-0.039212022,-0.04341895,0.0069162445,-0.03130699,-0.067713544,-0.058720555,0.036726553,-0.022852885,-0.007156619,0.06325258,0.06361113,-0.04004686,-0.003006149,0.025795478,0.049375612,-1.580085e-33,0.0233401,0.008567029,0.12761432,-0.08143409,-0.03334359,0.075401925,-0.008829983,-0.0055459864,-0.051486194,0.010818418,0.02641129,0.016555639,0.093537144,-0.009823517,-0.004509914,0.03803252,0.07500585,0.046725955,0.053724565,0.03123052,-0.116895474,0.06855931,0.021993797,0.0038874897,0.05973602,-0.004085822,0.04395162,0.055135846,0.0102031315,-0.04640174,0.04217715,0.037857942,-0.043011926,-0.037220173,-0.08681963,0.041165926,-0.02238218,-0.014983496,0.011579433,0.043850698,0.03265098,-0.020265177,0.010228385,0.09534565,0.0033059614,0.027007721,-0.0637712,-0.0075727045,-0.015163724,0.0166536,0.0621929,0.051899377,-0.062294904,0.051076267,0.028632533,0.07840644,0.049920738,0.02656312,-0.052782323,-0.05387224,-0.013508379,-0.06512051,-0.0527531,-0.07162165,0.075430475,0.07035717,0.027872086,0.010005186,0.05940489,-0.040437836,0.068766795,0.11469229,-0.00818131,0.07423665,-0.018920371,-0.0719375,-0.048567444,-0.007716605,-0.07435165,-0.0796502,0.032460958,0.038292367,-0.025344165,-0.09019262,0.057295825,-0.0579279,0.018691298,0.09543351,-0.024356134,0.00061475625,-0.011402692,-0.045589734,-0.09342674,0.065715365,0.047425233,-3.1412938e-08,0.0032284965,-0.07586946,0.011575079,-0.066808544,-0.025533378,0.042169914,0.019727644,0.025846371,0.036950767,0.03927173,-0.061048906,0.08382168,0.008854616,0.083742104,0.05464349,-0.020075014,-0.039927356,0.06996377,-0.013441164,0.015747678,-0.05518898,0.02722089,-0.088393144,0.051432643,0.0027271702,-0.0138446735,0.016511511,0.030146927,0.0661177,0.00013734197,0.048750196,0.04426678,0.06729391,-0.048932508,-0.10390123,0.008879246,0.028801799,-0.045361657,-0.064527154,-0.025509343,0.035270553,0.0027004038,-0.060532976,0.046160724,0.0038652164,-0.019840188,-0.012287144,0.04253945,0.06143554,0.051513944,0.026786696,0.017534884,0.011753725,-0.09270188,-0.1183628,-0.078631915,-0.0015223828,-0.015116256,-0.0018797945,-0.023378622,0.0035623293,-0.007411157,0.1724539,-0.011755613 +2.1.1.402,The enzyme has been isolated from gonads of the starfish Asterias rubens. It methylates N-glycolylneuraminate with equal specificity. Oligosaccharides containing N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosyl structures are also methylated.,384,1.0,-0.035403844,-0.029889299,-0.1495666,-0.0056384397,-0.04481976,0.0525147,-0.05331878,-0.052367166,-0.0008110098,-0.039036468,0.049078833,-0.00035717143,-0.050628655,-0.026984803,-0.081008725,0.030664098,0.032622006,-0.034837537,0.00979662,0.01168982,0.04402729,0.015321938,-0.060413424,-0.02876479,0.05000211,0.031404775,-0.019235507,-0.056064125,-0.024212923,-0.09271391,-0.0061695483,-0.0521746,0.046229307,-0.022673044,0.02741789,0.003143062,-0.022580948,-0.06382435,0.053631227,0.08989092,0.032196324,0.009385417,-0.05921111,-0.008166959,-0.07485059,-0.027554093,-0.022988195,-0.036630128,0.076083496,-0.03843025,-0.05400276,-0.11325007,-0.0070907837,0.027133476,0.016635362,0.065162815,-0.033991095,-0.07757398,-0.020594232,0.04679109,0.07765416,0.080176994,-0.015585783,-0.007687955,-0.05459982,0.0039622798,0.0042820037,-0.009069119,-0.010253689,-0.005826686,-0.02584023,-0.029911341,0.0069089285,0.020231614,-0.009725967,0.0484921,0.046837475,-0.015048147,0.120195195,-0.054949723,-0.0359877,-0.030324979,0.013985855,0.052235212,-0.0005014516,0.0054596155,0.02573806,0.10513871,0.04621904,0.028324464,-0.005037218,-0.037501093,0.003956965,-0.0953866,-0.00845348,-0.044944726,0.08061064,-0.039810292,0.10451636,-0.013473444,0.003182602,-0.019689947,0.046936844,-0.041157667,-0.070848286,0.07137829,0.029562613,0.044304077,0.0605022,-0.0036954503,-0.08901277,0.026768416,0.05688135,-0.018280216,-0.08557601,0.046034627,-0.0019426007,-0.06801061,0.00907521,-0.054131903,0.09028611,-0.028472537,0.115810625,0.03561034,0.017711895,0.11380462,-0.07086107,9.152839e-34,0.08358655,0.026213832,0.04851521,-0.033375323,0.087216236,0.04778678,-0.010839069,0.035487074,0.014823471,-0.08016161,-0.047519587,-0.08002901,-0.008234327,0.0561031,0.0638379,0.08752893,0.07142935,-0.050880566,0.04756972,-0.039170377,0.009156285,0.06563938,-0.04135134,-0.0065803295,0.011153426,-0.049823437,-0.035154175,0.003242658,0.029771853,0.003482137,0.06570729,-0.15536183,-0.08056985,0.0814818,0.090819426,0.086754456,-0.040459756,-0.015671946,-0.02038284,0.00013983714,0.066785626,0.0009003051,0.028401319,0.007484914,-0.04206032,-0.014143777,-0.06779218,0.036175832,0.07337042,0.04731212,0.013876473,0.0021823298,-0.0010011423,0.011722082,-0.061388787,0.10104228,-0.061059937,-0.001155136,-0.020934317,0.011627837,-0.02236376,-0.008343181,0.03643309,-0.030051619,0.037213624,0.03555165,-0.037459046,0.008305955,-0.05902842,0.00093735673,-0.0919017,-0.04212083,0.06525017,-0.043641955,-0.03376092,-0.02162101,-0.005441672,-0.0351673,0.0047084196,-0.05306979,-0.032378346,0.045998067,0.03376058,-0.021101037,-0.10538198,0.033618502,0.074849874,-0.0046198163,0.0340443,0.04737897,0.010812536,-0.065599784,-0.046544254,-0.031053256,0.008851465,-2.9321011e-33,-0.008009009,-0.093230344,0.052199017,-0.053048555,-0.03442265,0.07825432,0.05390716,0.016111754,-0.028369144,-0.044076536,0.0190508,0.052195787,0.031763565,-0.12541555,0.056098234,0.0040010465,-0.007836781,0.14424805,-0.0012883093,-0.034921292,-0.013508166,0.059435576,0.040116083,0.016687304,0.078350805,-0.05014266,-0.006657516,0.06765235,0.0016570392,0.063830234,0.045977924,0.07515612,-0.040074427,-0.08059962,-0.005432516,0.050385885,-0.07881641,0.006458575,0.017522383,0.03896544,-0.04236567,0.023082849,-0.0133684985,0.08100625,0.053560473,0.122279845,-0.065430574,0.015824854,0.013977201,-0.018047549,0.007699988,-0.049354605,-0.006279983,0.008458949,0.06235989,0.050903045,0.02908138,0.023356955,-0.012076273,-0.06670706,0.012543904,-0.02915241,-0.023359422,-0.026873715,0.025322715,0.0077516786,0.0009416745,-0.020446658,0.02970603,-0.021696186,0.0070178485,-0.0024957536,-0.03427294,0.11256662,-0.0061438433,-0.091769956,-0.10520926,-0.03441802,-0.034597054,-0.011091976,0.057520468,-0.0012836839,0.02793142,-0.08813427,-0.03815745,-0.05166003,0.0933766,0.11439498,-0.0025614444,0.019150855,-0.03434039,-0.02630537,-0.101719074,0.052605752,0.09861399,-4.1089542e-08,0.10923093,-0.06730112,-0.013133399,-0.068268314,-0.038345776,-0.013752239,-0.053768188,-0.04018999,0.06613581,-0.007455171,-0.03257517,0.023835823,-0.011828348,0.008836757,-0.059889246,0.030136354,0.023786334,0.04792405,-0.010692073,0.042878598,-0.10623871,0.057413936,-0.08338586,0.011282631,0.009815001,-0.024168445,0.050299145,0.06891629,0.030831357,-0.044899207,0.009745811,0.06945473,0.015163449,-0.06897445,-0.038865868,0.040165134,-0.0016425694,-0.0037077784,0.06293338,0.03877087,-0.0022939905,-0.0346049,0.022143403,0.017062772,-0.05649626,0.0072343047,0.023711767,0.0373267,-0.002364197,0.005291262,-0.028494976,0.004512565,-0.011269067,-0.12830874,-0.11378837,-0.027003665,-0.024832401,-0.04515511,-0.04071998,-0.018582644,-0.020602906,-0.013355187,0.1316016,0.013216471 +2.1.1.403,"Isolated from the plant Erythroxylum novogranatense. The enzyme, which is highly stereoselective, is involved in cocaine biosynthesis. The substrate, ecgonone, is unstable, and in the absence of the methyltransferase decarboxylates into tropinone.",384,1.0,-0.023772335,0.01746443,-0.14904712,0.00018093435,0.006181598,0.067732155,-0.054778684,0.04460135,-0.017210966,-0.055347163,0.05201782,-0.044541843,-0.042653788,-0.03544745,0.0033115654,0.04079213,-0.045498125,-0.017415468,0.012079848,-0.043899663,0.07680209,-0.0069183754,0.037646417,-0.00890801,0.026144681,0.047379427,0.009609505,0.017026842,0.02788834,-0.09742487,-0.059134904,0.0205758,0.04178518,-0.007514927,-0.0029510658,0.047327466,-0.0859261,-0.0069105364,0.1377652,0.048296086,-0.012632382,0.018143453,-0.01107709,-0.011477429,-0.053808983,-0.091664575,-0.0103589,0.039017826,-0.017590227,-0.107204154,0.06939026,-0.032461956,0.040550236,0.010848877,-0.011892973,0.015911374,0.0342479,-0.0016365378,0.0016285176,0.043576356,0.13815506,0.09555196,-0.035284605,-0.020338725,0.0014803661,0.03884455,0.0065951636,-0.028094925,0.057718396,-0.04923586,-0.056103576,-0.09018356,-0.014414856,0.071392655,-0.016999608,0.044425584,-0.013604588,0.03153194,-0.014385524,0.026885498,0.024919488,0.042764936,0.01813472,0.028098902,0.044100966,0.049125046,-0.060854852,0.09501669,-0.039342325,-0.0020578303,0.00044284787,0.02194597,-0.05263001,-0.008707872,-0.028586525,-0.008178998,0.030942531,0.005268536,0.014106976,-0.0040488197,0.08931715,0.096847154,-0.018643806,-0.094677664,-0.014853056,0.019684358,0.024233589,-0.0017035092,0.04029087,-0.019324243,-0.07704077,-0.0013070656,0.050194114,0.03557309,-0.010944436,0.072213896,0.008858843,-0.016903687,-0.03908892,0.011582692,0.012489592,0.00534872,0.020165013,0.049106833,0.028771672,-0.027174437,-0.12616691,2.9411131e-33,0.059860628,0.042496767,-0.04638137,0.011125866,0.06582542,0.06363445,-0.0064873206,0.0009323181,-0.051807087,0.02152957,-0.1388906,-0.06746544,-0.00072767714,0.04797561,0.0007203443,-0.002913427,-0.04889346,-0.008716262,0.06827798,-0.049790937,-0.022686675,-0.0028436168,-0.10053179,-0.00079356483,-0.08490998,0.06400092,-0.060249686,0.020935347,0.08588911,-0.01984222,0.017517162,-0.062459473,-0.047015697,-0.035220314,0.048237998,-0.049044535,-0.033078626,0.0011231656,-0.07492896,0.039394293,0.020031955,0.123387374,0.07454724,-0.030211164,0.07039752,-0.0004253764,-0.076013915,0.061460674,0.13674374,-0.014688022,-0.03157222,-0.030554643,0.06868665,-0.043209292,-0.04746746,0.025899097,-0.02561905,0.041204188,0.04358176,0.060863886,0.019711366,0.08436022,-0.021828573,0.017272776,0.018425476,0.10031231,-0.09545768,-0.065348074,-0.08762648,0.06175297,-0.03466475,-0.04811319,0.010193761,-0.023455802,0.040152248,-0.021192104,-0.050888404,-0.009043173,-0.014073157,-0.031915966,-0.035821497,-0.029605085,-0.008159249,-0.032861613,-0.04268675,0.030607097,-0.00019081132,-0.013906016,0.0136869475,0.16364521,-0.038679633,-0.03864984,-0.09521435,-0.035203584,0.046244517,-3.296966e-33,0.04250328,-0.010777282,0.052173957,-0.13220778,0.028790994,0.10231458,-0.0127954455,0.010185982,0.00040964884,0.02143441,0.04427532,0.01146286,0.10779412,-0.033451397,0.06039706,0.034310907,-0.002622264,0.11859972,-0.021728082,0.02297122,-0.06725143,0.03646715,-0.07238004,-0.0061859074,0.023047632,4.9713457e-05,-0.040973753,0.07381107,0.028400451,-0.0016838673,-0.017150993,0.04427535,-0.09043882,-0.023069719,-0.08982339,0.077551804,-0.08088007,-0.06525685,-0.015473311,0.012351256,-0.043349605,0.055427346,-0.056338027,0.08618755,0.09576779,0.021012861,-0.083965436,-0.030275397,-0.03914609,0.044332337,0.012346353,0.031048626,0.006860686,-0.020953042,0.057267163,-0.007161423,-0.002500008,-0.005199972,-0.022803267,-0.032732975,-0.022451518,0.011612242,-0.07083954,-0.023359492,0.061688803,0.01978301,0.0048418976,0.13073795,0.02265958,0.01324816,0.1272139,0.0018570342,0.00680171,0.068591334,-0.0333459,-0.019083051,-0.09682571,-0.06476431,-0.042080503,-0.025727235,0.023903677,-0.018167196,0.031153603,-0.04045076,-0.026099736,-0.0493566,0.020869125,0.059936266,0.030700047,0.02637808,0.05252966,-0.033019334,-0.11280304,0.017611267,0.06480736,-3.673214e-08,0.026090534,-0.05258099,0.047986865,0.019504491,-0.02399799,0.023031773,0.041322265,0.013017615,-0.019090582,-0.031999663,-0.048646286,-0.00090058945,-0.01591193,0.029005388,0.016132694,0.018550431,-0.002860719,0.10715882,0.010684164,0.032075442,-0.083338745,0.014804464,-0.013179229,-0.0018608003,0.028498707,-0.058003496,0.046127696,0.023585087,0.035942145,0.03594511,0.006631456,0.0060759108,-0.007874106,-0.022224015,-0.06999454,0.027224286,-0.06982618,-0.01776277,-0.051799603,-0.06847466,-0.0005062049,-0.06202052,-0.07059349,0.028348844,-0.0081240805,-0.028104763,0.018865626,-0.0088406755,0.04327011,-0.0600834,0.014827777,-0.067635685,0.06308843,-0.08515054,-0.048007887,-0.014682519,-0.03689381,-0.026927846,-0.00082093186,-0.049467918,-0.07664212,0.026116304,0.19262394,-0.03462503 +2.3.1.329,"The enzyme, found in some actinobacterial species, is a non-ribosomal peptide synthase (NRPS). Adenylation and thiolation domains of the enzyme activate a lysine residue and load it on the enzyme (this activity is described separately as EC 6.2.1.77, L-lysine---[L-lysyl-carrier protein] ligase). A condensation domain catalyses the condensation of two isonitrile-containing moieties to both amino groups of the lysine, a rare activity in non-ribosomal peptide biosynthesis. A reductase domain catalyses a four-electron reduction, releasing the product from the NRPS with a terminal alcohol group.",384,1.0,-0.020804176,-0.10889314,-0.12215051,0.013352687,0.030674798,0.06016147,-0.0665513,0.07054813,0.10414194,0.016772652,0.0013538598,-0.012132573,-0.007872578,0.06784013,0.0072217304,0.053105414,-0.09388195,-0.029646933,0.030668017,-0.019657243,0.067620106,0.048332058,-0.035678834,-0.004233137,0.057130527,-0.051651437,0.07797661,-0.06895226,-0.03241994,-0.038694084,0.02523673,-0.037512615,0.026410298,-0.09453727,0.107258365,0.07517539,-0.04518277,-0.05557065,0.0928726,-0.04505463,0.042193983,-0.034601424,-0.032457013,-0.015105945,-0.04068874,0.09986135,0.024766937,0.11843268,0.027488248,-0.058537725,-0.050889194,-0.05164955,-0.052162707,0.01947521,-0.04437554,-0.014002319,-0.06659516,-0.036860272,0.036701333,0.02672726,0.03993396,0.00787982,-0.0033605222,-0.008467757,0.035059795,-0.044990912,0.020037528,-0.003213438,0.046519093,-0.031947438,-0.042011417,-0.09878388,-0.01632472,0.075052194,0.023244325,-0.062273882,0.02544259,0.004320965,0.000789004,0.009146255,-0.0027242599,-0.0050531183,0.040158685,0.10008727,0.011051629,0.0026017136,0.013028849,-0.0074868705,0.039677273,-0.0064711957,-0.021896208,-0.044409048,0.033767454,-0.051015954,-0.072545215,-0.0037016557,-0.030334646,0.019387772,-0.00674167,0.017038079,0.0025806315,0.053599805,-0.027082892,-0.05668332,-0.008222642,-0.0033242046,0.0015050655,0.1268661,0.0013205037,-0.0041567315,0.03148932,0.021447089,0.020037793,-0.02564574,0.008931911,0.084784694,0.04499727,-0.0422725,-0.06639263,-0.019660262,0.0040805894,0.020904083,0.07544947,0.0632537,-0.034418926,0.049438793,-0.13662489,8.224641e-34,0.056598686,0.016099636,0.057380266,-0.044339355,0.015173165,-0.037568506,-0.09098,0.0006017332,0.054635294,0.02887831,-0.051279932,-0.08562053,0.08351968,-0.03848472,0.020195207,-0.060717866,-0.035458837,0.017182028,0.10560877,0.089015745,-0.06648058,0.062497385,0.020417238,0.07923266,0.022955315,0.029034264,-0.025025045,-0.035527255,0.039958194,-0.010456045,-0.0061652996,-0.029178947,-0.12135894,0.010315138,0.054798935,-0.028057445,-0.059196398,-0.07037794,0.068258636,0.038403627,-0.01955798,0.023500126,-0.042352255,-0.017377954,0.058957938,0.0058691194,-0.05237739,0.07524783,-0.03302108,0.048520215,0.08711211,-0.027784012,0.14075667,-0.08126415,-0.043093152,0.0065368284,-0.03646244,-0.0007651895,0.025317596,0.017401079,0.028723594,0.013664108,-0.020113593,0.028192695,-0.030353533,-0.023326209,-0.036919,-0.11474403,0.045358207,0.01046282,-0.068048045,0.037985865,0.15270951,-0.0276249,0.042937912,-0.04140432,-0.084800996,-0.021550762,0.044572994,0.032357685,-0.015421523,0.026552605,-0.070685394,-0.060214404,0.041001253,-0.054270335,0.0019020151,-0.07950144,-0.01853004,-0.009605058,0.009672817,-0.06447208,-0.09194519,0.06983709,0.016457733,-1.8692191e-33,0.120884195,-0.1446022,-0.0208454,-0.06351821,-0.03721581,-0.019994028,0.034485605,-0.056254312,0.01965812,-0.04849794,0.05724393,0.016374562,-0.03971834,-0.02778898,0.04598581,-0.0328251,0.036023956,0.030856078,-0.001123307,-0.04385302,0.01689653,0.04978176,0.0045286217,0.004551443,0.016652279,0.00022888283,-0.051276557,0.082401216,0.09247192,0.017032806,0.015314603,-0.016888076,-0.029751467,-0.08514967,-0.035715926,0.089100175,-0.052860964,0.050768673,0.04939415,-0.089961186,0.05902462,0.07022551,-0.027729414,0.07688375,0.027325144,0.04481409,-0.033864822,0.0020637237,-0.019192986,-0.11818378,0.06724519,-0.06226024,0.01592316,-0.0051960335,-0.022781644,0.019947426,-0.0073728007,0.043093707,-0.010848074,0.0092029935,-0.05246288,-0.06142162,0.042138617,0.021401433,0.033875916,0.024703879,-0.010715063,0.07682637,0.03926366,-0.012872374,0.053890694,0.009282845,0.009791164,0.025761183,-0.016843906,-0.029159524,-0.02440019,-0.09980658,-0.0448328,-0.073623106,-0.054996457,-0.03520963,-0.04026325,-0.028155318,-0.002505511,-0.03724097,0.056381114,0.10718906,0.0027864166,0.060145058,0.045273084,0.020490605,0.069907375,0.03381047,0.052375555,-4.458795e-08,0.08418058,0.021938257,0.029062033,-0.045475088,0.02435103,-0.0001516814,-0.040186003,-0.024689106,0.017248586,-0.018540172,-0.02178461,0.051740397,-0.051812764,-0.05816382,0.094780855,0.028954135,-0.045244165,0.065851964,-0.040823728,-0.021634348,-0.031314444,0.04256384,-0.13161668,0.024240451,-0.026337242,-0.063797854,0.03980566,-0.056991126,0.04052989,-0.006344684,0.052195836,0.0799252,0.05181407,-0.023748368,-0.059707914,-0.048438385,-0.022520341,-0.048327703,0.008018943,0.0112401135,-0.04666492,-0.005752438,-0.06574073,0.01221653,-0.040228553,0.053079825,-0.020256754,0.0012416872,-0.005216628,0.02241676,0.038576253,0.039814238,-0.05820725,-0.013968519,-0.08776661,0.07769521,-0.033027627,-0.053250737,-0.0015851526,-0.046093423,0.010844891,0.005916573,0.12942193,0.0012246177 +2.3.1.330,"This enzyme system produces glycolyl-[acp] units that can be used by non-ribosomal peptide synthases. It catalyses a transketolase-like reaction on ketose phosphates derived from primary metabolism and transfers the resulting glycolyl moiety to a dedicated acyl-carrier protein. During the reaction cycle the glycolyl moiety is transferred first to a thiamine diphosphate cofactor, then to a lipoyl cofactor, and eventually to the acyl-carrier protein. While D-xylulose 5-phosphate is the best substrate, the enzyme can also accept D-fructose 6-phosphate and D-sedheptulose 7-phosphate. During the reaction the lipoyl cofactor is reduced to dihydrolipoyl, which must be oxidized back to lipoyl by an unknown enzyme.",384,1.0,-0.055839412,-0.098366715,-0.116836876,-0.031542584,0.012171565,-0.014429565,-0.06169255,0.04014116,0.03488647,0.024524897,0.036315933,0.03321752,-0.06709243,0.0069943275,-0.05476859,0.020215295,0.03198979,0.03169803,-0.019847909,-0.062222283,0.08794865,-0.031922795,-0.029905483,-0.021545775,0.03576872,-0.031165063,0.016663816,-0.033630095,-0.046284616,-0.08469391,-0.06599831,-0.04862286,-0.017566672,-0.04408387,-0.0012991307,0.12763931,-0.0164115,-0.004016071,0.053880278,-0.03863203,0.04241112,-0.06843694,-0.0026363845,-0.017491173,-0.05041052,-0.033812683,-0.05729272,0.11357592,-0.0038915996,0.0022966468,-0.074818976,-0.03220954,-0.036961243,-0.044260286,0.0047149262,0.04073006,-0.020819074,-0.023421736,-0.023334393,-0.0077767046,-0.058525633,0.006535501,-0.010294732,0.026731955,-0.006610487,-0.12711456,0.01952711,-0.034857165,0.017076952,-0.022983875,-0.07326435,-0.056402016,-0.016970657,0.004202608,0.008640555,-0.0007924791,-0.015586146,-0.01579785,0.09220183,0.023125043,0.06219209,0.036074378,0.1003755,0.0656756,0.015572092,-0.011986069,0.0050232117,0.056079324,-0.008326725,-0.020496408,0.04313303,0.0144092245,-0.00939158,-0.032534216,-0.08001728,0.02193571,0.078655146,-0.024343383,-0.02303575,-0.039557666,0.01544941,0.0472062,0.03172138,-0.06603419,-0.0904909,0.032233544,-0.015812915,0.10177924,-0.0029373497,-0.012688046,-0.031186754,0.009118067,0.005977686,-0.017596224,-0.011645393,0.07778143,-0.028219305,-0.071414545,-0.022212045,-0.046443924,-0.01378352,-0.01946471,0.065999016,0.11744639,-0.07232625,0.07740965,-0.052817553,4.1927584e-33,0.03962118,0.07100407,-0.018988574,-0.03318866,-0.06134412,-0.039945148,-0.06374894,0.05647014,-0.017691692,0.0074473945,0.0103235375,-0.09447808,0.05041707,0.037231214,-0.008952247,-0.06871891,-0.009815062,0.026506014,0.07892623,0.046745125,0.043177195,0.06844024,0.008899967,0.040069886,0.07993624,0.07405223,-0.044919513,0.033486888,0.0020115995,-0.0025278942,-0.008746947,-0.048247285,-0.069679365,0.047932066,0.052589186,0.004485556,-0.056825418,-0.040155977,0.04268077,0.048142977,0.017915621,-0.03884542,0.020567264,-0.06862902,0.04202971,0.023753632,-0.05714764,0.01652084,-0.000707341,0.0475082,0.10035922,0.01992316,0.070209794,-0.009759989,-0.055698287,0.049312837,-0.062879354,-0.035639588,0.04465491,0.021701423,-0.026594598,-0.0019414681,-0.03970871,-0.007985765,-0.031282343,0.014135903,-0.07246972,-0.10309371,-0.003023533,0.10573641,-0.0068377894,-0.014123643,0.10907599,0.028315669,0.043054644,-0.040939238,-0.021426277,0.0701758,0.0100508295,0.013675638,0.05082587,0.02716906,-0.008406801,-0.08017431,0.01832521,-0.039610572,-0.031026736,-0.05919932,-0.025527751,0.022793405,0.026912954,-0.0682615,-0.013684468,0.06042351,0.03450022,-5.661386e-33,0.15031235,-0.10341532,0.060743716,-0.07220165,-0.09153468,0.027380666,0.046698477,-0.040315285,0.061058525,-0.05448756,0.0072919573,0.03819395,0.0072832396,-0.025347752,-0.01603437,0.047792476,-0.057027057,0.045236353,0.004472031,-0.02846605,0.024946153,0.09229466,0.021688145,0.0480779,0.060934566,-0.0036106645,-0.045643598,0.019151267,0.07609408,0.019658746,-0.010987603,-0.022525428,0.011640519,-0.023161024,-0.060400866,0.0716477,-0.14343095,0.05247064,-0.016329654,0.07731768,-0.007584553,0.07843461,0.041868124,-0.0073616137,0.034513216,0.052557662,-0.048097912,-0.033617858,0.013949514,-0.08383427,0.055678964,0.02122079,-0.036326874,0.024588376,0.013945852,0.12883905,0.08735281,0.045031223,-0.052019656,-0.052381605,-0.081349455,-0.10729152,0.07223844,-0.013158895,0.06680502,0.08619672,-0.026880331,0.045414433,0.007102075,0.02989457,0.0013915669,0.011361603,0.022305839,0.044194244,0.03730201,-0.055360813,-0.08750698,-0.017601756,-0.0350889,0.016598297,-0.02789548,0.008719505,-0.0022449812,-0.015523742,-0.013707796,-0.077698424,0.04940794,0.062765986,-0.00690886,0.047836225,-0.007647436,-0.012885602,0.04079044,0.034084585,0.15655409,-4.5500123e-08,0.034392618,-0.020329755,0.05284974,-0.08296038,-0.022568882,0.02502281,0.01360963,-0.047399286,0.037162125,-0.05736443,-0.086095184,0.10828918,0.0041190386,0.046210296,0.003555526,0.013599422,-0.05225457,-0.02076471,-0.004376213,-0.077977136,-0.08017334,0.011004863,-0.08493018,0.082740285,-0.0135439485,-0.035934936,0.040858306,0.012721197,0.013998071,0.039183516,-0.054060735,0.057371635,-0.022326268,-0.031828303,-0.012466162,0.017088281,-0.019423012,-0.08158803,-0.012972499,0.044694085,0.020847324,-0.049711976,-0.020455943,0.021710273,0.009909902,0.003263328,0.019601556,-0.01996951,-0.022571726,0.06817906,0.026874905,0.01913854,-0.050358154,-0.118292,-0.03654345,0.017166233,-0.05905217,-0.053604938,0.020204315,-0.04637658,0.0020284166,0.014867447,0.20855471,-0.08279451 +2.3.1.331,"The enzyme has been isolated from the bacterium Chryseobacterium sp. 5-3B. Reduced activity has been observed with L-2-phenylglycine methyl ester, L-2-chlorophenylglycine and L-4-hydroxyphenylglycine.",384,0.99999994,-0.019958703,-0.052360717,-0.067925245,-0.028067896,0.029313277,0.14863114,-0.0754489,-0.0160457,0.04003642,-0.03305563,-0.01715665,-0.030433679,0.049007606,0.00051712233,-0.035044502,0.0423915,-0.10590736,-0.05478376,-0.023389518,-0.024019782,0.04836769,-0.020459807,-0.084880866,0.0075221583,0.01945414,-0.0005193682,0.097613335,-0.074670814,-0.066922285,-0.041609738,-0.030198446,-0.034210794,0.009670363,-0.09553766,0.07944677,0.07518273,-0.074844174,-0.06936626,0.10525075,0.0379731,0.0046903617,-0.0115316985,-0.055505134,-0.025421334,-0.104653396,0.006386975,0.07173167,-0.009912633,0.046784602,-0.049741425,-0.09564542,-0.037662216,-0.012751903,0.039957516,-0.049486693,-0.045973677,-0.04920576,-0.013880927,-0.024858277,-0.02553501,-0.0024441846,0.053912405,0.10028041,0.0082706865,-0.041342195,-0.050860465,-0.03897777,-0.077954225,0.05250085,-0.10431247,-0.06821823,-0.066782124,0.026350658,-0.029257858,-0.0065201353,-0.042639494,0.04431094,-0.038753033,0.036941685,-0.02837935,-0.039417423,-0.10479279,-0.009475948,0.06271418,-0.029264843,-0.016695084,0.01969573,0.026523093,0.061782796,0.0414924,0.08032923,0.02796311,-0.014001578,-0.03875268,-0.06184302,0.058112994,-0.046591975,0.0008214299,0.028603273,-0.04780118,0.009140553,0.028361086,-0.030275853,-0.11086613,-0.07536555,-0.028149989,0.017224541,0.07327824,0.02769425,-0.022077838,-0.011818053,0.060358796,-0.0394311,-0.03704504,0.001456381,0.061181467,0.06538902,-0.09978797,-0.031226479,0.019518655,0.062019356,-0.033679973,0.098533906,0.0073927864,-0.033284128,0.14573298,-0.10280097,4.047167e-33,0.060929514,0.044314314,0.015163899,-0.033121478,-0.00016740833,-0.025426628,-0.07657842,0.038063888,-0.027664216,-0.07781957,-0.047357637,-0.045461267,-0.019036973,-0.084378034,-0.007554859,0.019085819,-0.013788702,-0.00488956,0.059746828,0.056896415,-0.0034137976,0.06592726,-0.02183123,0.10144701,0.042454712,0.05200857,0.043228287,0.0106586125,0.08378925,-0.010388663,0.061900746,-0.099112496,-0.07124578,-0.0514198,0.10421194,-0.031513087,-0.049029313,0.019553393,-0.022250492,-0.0056900177,0.073385164,-0.012987341,0.07682672,-0.009518955,0.07478329,-0.007934059,-0.06060149,0.06088005,0.039259404,-0.009549587,0.03591548,-0.012496029,0.116584055,-0.018694252,-0.00029331623,-0.011274806,-0.022618102,-0.0016039123,0.040058617,0.043967437,0.011529771,0.087388135,0.01657829,0.00958033,0.052218184,-0.029668052,0.0013706476,0.016982215,-0.015147821,0.06718637,-0.050190628,-0.02545805,0.096223935,0.0036966177,0.086804576,-0.043177053,-0.040265292,-0.107361756,0.044364877,0.015051019,0.02410636,-0.049405262,0.0709729,-0.020202177,-0.02596636,-0.022777317,-0.04905058,-0.0035360835,0.042024177,0.057922997,0.058419447,-0.050977115,-0.05397998,0.05097025,-0.07618046,-5.6488557e-33,0.0123792505,-0.09736666,0.037158564,-0.06326267,-0.052519996,0.038461454,-0.016221475,0.022263821,0.009922303,0.035088785,0.11083381,0.052304126,-0.0026684853,-0.03784113,0.047231887,0.08730883,0.07804369,0.055672664,-0.057573717,0.011537503,-0.05050049,0.038132876,-0.0018823453,-0.015411895,0.024179274,0.01191631,0.016069926,0.1258041,0.07885077,-0.0007055369,0.03696327,-0.00011313629,0.005392373,-0.059139628,-0.07241335,-0.020118166,-0.048900526,-0.065451615,0.082367316,0.011653443,0.014938689,-0.014806488,-0.043007247,0.04104232,-0.008275933,0.011686889,-0.0667381,-0.027443876,0.0048412555,0.0028839642,-0.040202424,-0.017239902,0.014060643,-0.061389145,0.005270366,0.016757393,-0.047268033,0.027000073,-0.012293477,0.002694176,0.004246375,-0.03914144,-0.019033616,0.07673469,0.030679548,0.06677717,-0.063534476,0.07171517,0.024896959,-0.007824542,0.029874593,0.06039862,0.031741098,0.06367874,-0.004831523,0.07924207,-0.025987275,-0.0012924906,0.031842586,0.042511135,0.05314521,-0.008404544,0.0051316964,-0.13655466,-0.0567586,-0.088498436,-0.014491496,0.07409454,-0.019952135,0.018099189,-0.013056542,-0.005542607,-0.008891005,0.031054037,0.03159416,-4.0811425e-08,-0.0044952477,-0.05467787,0.07501173,-0.075482965,0.055328306,0.01679155,-0.07932302,-0.06528627,0.0634037,-0.0034041028,-0.033303965,-0.027182894,-0.0016973861,0.023694465,0.013774061,0.021942966,0.0010474724,0.01213928,0.016682811,0.054923262,-0.056346744,0.025367523,-0.1204319,0.0051767305,0.017031882,-0.00017402087,0.0015924621,-0.02208882,-0.010081978,-0.013798202,-0.064382866,0.018009428,0.038646825,-0.018866912,-0.08188597,0.0250534,-0.05867478,-0.019686319,-0.08101066,0.12218973,0.10436058,-0.008431718,-0.059950374,0.012061252,-0.0049086004,-0.025674578,-0.04681771,-0.003721213,-0.022574902,-0.03549297,0.03115441,-0.011515507,-0.027248176,-0.04414167,-0.05570912,0.033475075,0.0027374828,-0.07763253,-0.07491945,-0.071930565,-0.0423223,0.0340617,0.096596606,0.048215754 +2.3.1.332,"The enzyme transfers an acyl group from an acyl-CoA to a medium-chain fatty alcohol, forming a wax ester. Wax esters have diverse biological functions in bacteria, insects, mammals, and terrestrial plants.The enzyme from the plant Petunia x hybrida prefers medium chain alcohols and saturated very long-chain acyl-CoAs. The human enzyme AWAT1 prefers decan-1-ol (C10) and has lower activity with C16, C18, and C20 alcohols. cf. EC 2.3.1.75, long-chain-alcohol O-fatty-acyltransferase.",384,0.99999994,-0.06734137,-0.034777008,-0.073630795,-0.030053599,0.05183317,0.040717337,-0.08902684,0.01573832,0.0063649025,-0.046847895,0.13914631,-0.067689,-0.15204784,0.023518382,-0.009896121,0.029680304,-0.06899198,0.021684328,-0.055550735,-0.08223664,0.026407743,0.015537918,0.03783171,0.038529478,0.022650057,-0.083717585,-0.017836425,-0.034999777,0.03138718,-0.14210458,0.03293232,-0.0012469942,0.048626415,-0.05550669,0.023431435,0.030192643,-0.007860824,-0.13576677,0.093634,-0.010790242,0.050219838,-0.019906592,-0.026333073,-0.02450112,-0.060528096,-0.07032996,-0.017377935,0.012064728,0.08785562,0.037386794,0.016808743,0.010099456,-0.08215989,0.044108212,0.0034992236,-0.042898435,-0.047372915,-0.023127256,-0.021851089,0.039477114,0.031961415,0.064018615,0.028780397,0.038355093,-0.016686648,-0.072911,-0.03233986,-0.044808242,0.031239444,-0.049048837,-0.09286946,-0.108965814,-0.016279321,0.07557919,0.013595888,-0.0141036585,-0.05738605,-0.020654256,-0.021755734,0.011466883,-0.02617406,0.00407825,0.017810494,0.088876314,0.033260703,-0.027369706,-0.04112505,0.008903182,-0.013488982,0.10260127,0.018524963,0.009524212,0.003735785,-0.0018914263,-0.01911487,0.043809414,0.069205865,0.010688389,0.040304538,0.0055925716,-0.035018466,0.048224103,0.029533697,-0.106354244,-0.09007479,-0.072295584,-0.029825535,0.0015976545,0.026190307,0.010967272,-0.037929356,-0.034223706,0.015231278,0.012743231,-0.069058746,-0.0030508426,-0.026462022,-0.09370014,0.035196718,-0.025364524,-0.014376384,-0.059314422,0.05331642,0.1073068,0.055285063,0.017035427,-0.12732725,1.440979e-34,0.05413848,0.01938943,-0.059483875,-0.010081711,0.0021773388,-0.044335682,-0.060834747,0.05429527,-0.11243136,0.021738864,-0.09205037,0.011037022,0.01924839,0.013689692,0.04440002,-0.025522463,0.038146462,-0.0083427215,0.057713676,0.017692082,0.009439435,0.05588002,-0.030131808,-0.026095694,0.064751364,-0.0012738144,-0.04482446,0.018797154,-0.007872655,-0.0046664993,-0.008831273,-0.05404454,-0.018082228,0.07910966,0.06596475,0.063870005,-0.02065069,-0.07605409,-0.03643837,0.06917956,0.06830258,0.060132157,0.09007812,-0.053279184,0.022251802,-0.028594015,-0.13903064,0.07488074,0.06457086,0.07029348,0.03017204,0.04230552,0.072523706,0.06666093,-0.031582303,-7.7086304e-05,-0.044970926,0.0057549113,-0.039024156,-0.02683875,-0.04434138,0.032033462,-0.043053538,-0.046319943,-0.018792488,-0.015420844,-0.120411344,0.0035936185,-0.05218744,0.06645644,-0.029955257,-0.05564705,0.008000107,0.0012243845,0.09277861,0.004179913,-0.05673253,0.0822471,0.054494184,0.020089937,-0.037823565,0.057731047,0.035078384,-0.05201487,-0.08724629,-0.005721255,-0.017968744,0.029608777,0.024457252,0.018620757,0.038904447,0.0064174095,0.03684329,0.057637434,0.057323538,-1.688663e-33,0.05514786,-0.07719872,0.083725736,-0.07368917,-0.057764173,0.059213612,0.01917855,-0.012079982,0.01572096,0.028149055,0.10213846,-0.00086899596,0.043904744,-0.056182366,0.016059127,0.040089514,0.031187084,0.05204831,0.023250882,-0.02628753,-0.04877985,0.109140866,0.017410913,0.01645398,-0.025267053,-0.0016292722,0.026529282,0.048025265,0.03506111,-0.017232016,-0.016457137,-0.036494583,-0.0352958,-0.025781875,-0.04625746,0.019622186,-0.087123156,0.00826761,-0.04866349,0.046536673,0.06471355,0.000796451,0.012258131,-0.019090308,0.057242718,0.042131785,-0.026828192,-0.030716425,-0.026559116,0.0011287081,0.08747579,0.01097201,0.034338195,0.005414346,0.043770194,0.11349503,0.049698766,0.008865479,-0.03910021,-0.07829537,0.012151339,-0.042884964,0.01922288,0.05989337,-0.051457766,-0.016337723,-0.041736815,-0.037776068,-0.00015262293,0.021871598,0.07360318,0.06449223,-0.009395313,0.04863836,-0.016035529,-0.043349307,-0.01738401,-0.100790784,-0.0016526532,-0.036179096,-0.07759061,0.025242498,-0.034035314,-0.050554708,-0.003943095,-0.0018629463,-0.04218192,0.08630874,0.006703815,0.03910317,0.011795072,0.0038376714,-0.02442495,0.03151484,0.030554827,-3.9395513e-08,-0.06697399,-0.0545013,0.009988104,0.00853904,-0.0030655528,0.03637731,0.029477326,-0.067763366,0.021799188,-0.019800909,-0.020419756,0.12791017,0.040241886,-0.012796373,0.06296373,0.020724611,0.043838378,0.026151199,-0.0035537053,-0.019930871,-0.089265704,0.034243435,-0.05207013,0.0443598,-0.015233529,-0.037824377,0.04351454,0.12172707,-0.0020938437,0.026680356,-0.026344642,0.06968611,-0.009952816,-0.019477561,-0.015556403,-0.017142404,0.071320534,-0.056149695,-0.04683917,0.08782563,0.05476291,-0.044826884,-0.09649826,-0.011782385,0.055432927,-0.024801599,0.061747614,0.0022921269,-0.024442675,0.050047096,0.12123025,0.026773436,0.0060715117,-0.050685816,-0.016042717,-0.05723272,-0.0066385474,-0.050589833,-0.016580023,-0.018415082,0.06591927,-0.03644226,0.1864031,-0.014486186 +2.3.1.333,"The enzyme has been isolated from the plants Erythroxylum novogranatense and Atropa belladonna, and is widely distributed in Solanaceae and Erythroxylaceae plants, where it is involved in the biosynthesis of tropane alkaloids. The enzyme has also been isolated from the club-moss Huperzia serrata, and by implication is likely present in other Lycopodiaceae plants, where it is involved in the biosynthesis of lycopodium alkaloids.",384,0.99999994,-0.070057474,-0.07631514,-0.16602689,0.041745547,0.0111083025,0.06739717,-0.09254671,-0.008140657,0.03244944,-0.031162763,0.034029663,0.0063502765,-0.03693376,-0.023864087,-0.047877375,0.08151615,-0.084274866,-0.00827305,0.0023289064,-3.1592906e-05,0.03840955,0.059935916,0.01670279,0.045275632,0.10218575,-0.07638485,-0.021147296,-0.041000023,-0.005490476,-0.051106703,-0.021681517,-0.020793386,0.05418417,-0.024152135,0.0471945,0.041443978,-0.08412682,-0.056069672,0.09656346,0.05011442,0.003343771,-0.05445668,-0.08315759,0.0033642296,-0.10236553,-0.05643275,-0.046682596,0.028721437,-0.02674912,0.038302653,-0.03557571,-0.06708498,-0.03569444,0.007908308,-0.045665424,-0.05600523,0.01839675,0.06266584,-0.01272972,0.045612574,0.13051291,0.057510793,-0.029377174,-0.010796464,-0.04645963,-0.046993874,-0.035315268,-0.004326441,0.11946431,-0.13642862,-0.010980149,-0.10082953,0.017960478,0.05928323,-0.0004957066,0.004263243,0.007015242,0.04212373,-0.039036326,0.03565278,0.092962846,0.046496913,0.0060753245,0.07028578,0.015442037,0.033831537,-0.007284325,0.11351758,0.005373574,-0.032844715,0.09984504,-0.026313873,-0.018930178,-0.0569049,-0.027482646,0.06953278,0.022602258,0.011157672,-0.012464024,-0.059738815,0.036585707,-0.028630925,-0.026625512,-0.081499204,-0.017673932,0.010248869,-0.0017025588,-0.024029192,0.013596748,-0.060171265,0.021250386,0.028474975,0.0028098791,2.5579686e-05,-0.036050327,0.07927332,0.04493515,-0.060520288,-0.012707138,0.02842193,-0.035341844,-0.0042446787,0.117583364,0.055232506,0.02772156,0.025226003,-0.10958554,4.2923852e-33,0.0759995,0.022991387,-0.045269374,0.0014708291,0.04177191,-0.010687583,-0.022472076,-0.020538852,-0.10549904,-0.028777078,-0.13164976,-0.010443066,0.037487574,-0.032655288,-0.005879926,0.04098781,-0.015192244,-0.022427293,0.07639045,0.0011443888,-0.0044136853,0.02051127,-0.10016576,0.059350546,-0.06699799,0.06600367,-0.022736603,0.0009857259,0.02651648,-0.009041556,0.03984769,-0.12728648,-0.047635376,0.039345976,0.042138524,-0.017127782,-0.05546135,0.020319376,-0.039388984,0.014579231,0.028409569,0.1091348,0.04892651,-0.016044423,0.059038647,0.011057804,-0.028216913,0.059574928,0.09083174,0.016970139,-0.01196147,-0.009078533,0.0714854,0.006555372,-0.04679131,0.049569245,0.009772056,0.05086858,0.09589228,0.06466083,0.00860544,-0.005405811,-0.0021462434,0.025297813,0.04017302,0.041710734,-0.06443858,-0.041817587,-0.04695868,0.08538564,-0.045496818,-0.046449307,0.00073460164,0.022142004,0.009554735,-0.042450424,0.024587007,-0.0035615014,-0.018600455,-0.04093646,0.0105648665,-0.041923456,0.02257947,0.036098436,-0.048820265,-0.03298279,-0.035802595,0.015280886,-0.04688473,0.0834423,-0.03215453,-0.016395455,-0.06447804,-0.017894413,0.050203074,-4.720196e-33,0.11634234,-0.08352248,0.025876924,-0.119927876,-0.045254663,0.105264306,-0.025023289,-0.00954323,0.013038578,0.10914686,0.07981144,0.049428914,0.0375914,0.005377883,-0.013646076,-0.010836776,0.052347858,0.053649306,0.00650602,0.019580374,-0.092932165,0.031664796,0.012557625,-0.046022166,-0.022017682,-0.032269817,0.040645316,0.0077086715,-0.0434146,0.01992858,0.013955659,-0.034658052,-0.05248003,-0.006002028,-0.09549878,0.005969854,-0.06386709,-0.033112448,0.033648286,0.028994583,0.05173184,0.002681577,0.002999627,0.022075042,0.09681914,-0.04770378,-0.1033781,-0.016214604,-0.08349525,-0.022385573,0.06619765,0.01508374,0.064361505,-0.008814315,0.02410939,0.002150077,0.021366168,0.024835583,-0.03572705,0.00621297,0.015099359,-0.020998094,-0.066888526,0.022089906,0.04030285,0.07362153,-0.071338266,0.09274467,-0.048916217,0.007330254,0.049502637,-0.00911564,-0.0110592,0.10103189,-0.06078257,-0.03733899,-0.03690614,-0.083178304,0.02144602,-0.037396003,0.0376709,-0.017474322,0.037732042,-0.08169259,-0.03462333,-0.03566781,0.05027143,0.10582082,0.044680897,0.04646339,0.036046416,-0.007996475,-0.067559,0.011651203,0.13166448,-3.8919826e-08,-0.0027547944,0.004526563,0.017954096,0.001020359,-0.01957102,-0.025716202,0.015399064,0.0027803523,-0.019428415,0.008901213,-0.028423507,0.008361025,-0.04409623,0.043134563,0.076573916,0.02681624,-0.0024141825,0.062424537,-0.0034400562,0.0700509,-0.018142225,0.023897765,-0.008126735,-0.0234147,-0.0061609154,-0.03647508,0.018527677,0.00260776,0.0636023,-0.029220495,0.021861851,-0.013678172,0.0045902296,-0.026154133,-0.105920814,0.010893749,-0.05868752,-0.0656687,-0.040057186,0.025751555,-0.012367317,-0.036702722,-0.030028222,0.00522225,-0.094192944,0.04021491,0.020023504,-0.042225067,0.07090708,0.03336691,0.01912206,-0.059638258,0.050874356,-0.09160608,-0.09931987,0.020783627,-0.027381938,-0.036485676,-0.017459963,-0.09526839,-0.025403537,0.027752686,0.1492149,0.012962452 +2.3.1.334,Isolated from the plant Erythoxylum coca. Cinnamoyl-CoA can substitute for benzoyl-CoA.,384,0.99999994,-0.07975999,-0.022424122,-0.08943322,0.0008427519,0.08701044,0.09024486,-0.07783386,0.05556857,0.026108544,-0.13250989,0.0823194,-0.09994994,-0.013681198,-0.007620335,0.0026240812,0.034269407,0.019881962,0.04134359,-0.037980106,-0.007630017,-0.04291562,0.06007164,-0.00975463,0.06432461,-0.0008501792,-0.0057608853,-0.022370204,0.031387605,0.0149066355,-0.106272206,0.0017021485,0.02976083,0.032355197,-0.008438198,-0.0002823109,-0.0410404,-0.09614089,-0.038149312,0.12066054,0.020431487,-0.009045948,-0.026336063,-0.02796308,-0.0007954142,-0.0996113,-0.050170053,-0.0022236777,0.03285535,0.055171076,-0.07289169,0.020112522,0.03895593,-0.07223331,0.032810323,-0.034794375,-0.012861559,0.018840674,0.011894226,-0.0046037748,0.06951042,0.09742211,0.04653392,-0.029062157,-0.011804367,-0.0944841,0.030293647,-0.027619582,0.022860052,0.120475404,-0.026935872,-0.10108521,-0.0628549,0.013209235,0.039880402,-0.049938906,0.07030692,0.04864587,0.023157839,-0.019809015,0.024998654,-0.05036719,0.06793609,0.010715847,0.061999623,0.04608432,0.06904864,-0.054260883,0.0693716,0.013228185,-0.017337859,0.068355225,0.06714997,-0.06060372,0.022416785,-0.10618784,0.09204436,0.049038272,-0.052989315,-0.010544602,0.036879674,0.056144815,0.06686991,-0.00666655,-0.16668849,-0.08247846,-0.0026683637,0.013014621,-0.058549646,0.019495375,-0.07139001,-0.044975538,-0.06492663,-0.014140071,-0.016119562,-0.016808541,0.029583713,0.05026933,-0.0012212839,-0.014778337,0.0150768645,0.012823275,-0.0057970593,0.061777662,-0.034170102,0.0034235187,-0.029960688,-0.074183546,1.1285147e-33,0.032168157,0.03951045,0.03310242,0.062743366,0.07571072,0.011406753,-0.053197898,0.063281305,-0.051727746,-0.0974719,-0.023677785,-0.028255276,-0.0331577,0.0047912765,-0.02579861,-0.034505885,-0.017582815,-0.062206708,0.060039584,-0.05147308,0.02106171,-0.0014064839,-0.0628188,-0.012384618,-0.035601526,0.024867522,-0.0582795,0.077375315,0.0478828,0.03201254,-0.05148391,-0.036895134,-0.04946641,0.03086607,-0.01048047,-0.0048066485,-0.08629544,-0.013041067,-0.0055696582,0.027844066,0.07364125,0.09132417,0.025786683,0.018807918,0.028703358,-0.0062915194,-0.07749361,0.08797101,0.08728835,-0.06994002,0.046300583,-0.041838594,0.05666128,-0.051936865,-0.023675209,0.031754773,-0.020263065,0.040854327,0.027592128,0.004415334,0.0091039175,0.10437065,-0.03112845,0.030251948,0.09277864,0.055788465,-0.12420221,0.002153663,-0.074708395,-0.020647751,-0.0047687907,-0.024270436,0.07329618,0.032584164,-0.011424355,-0.057134207,-0.010475038,0.029897483,0.11048722,0.059796516,-0.025982335,-0.019604247,0.031759646,-0.0015538926,0.00020138478,-0.017401459,0.03133428,0.07003872,-0.003106812,0.060938247,0.026875367,-0.05121542,-0.0015824445,-0.03986165,0.025691453,-1.89811e-33,0.08897178,-0.016869891,0.028614426,-0.080385655,0.03013781,0.0018382263,0.0054316595,-0.05923672,0.026587315,0.03250988,0.02524394,-0.00038418663,0.028985536,-0.0018234184,0.010116773,0.05338822,0.064197905,0.03154433,-0.07174577,0.008249155,-0.10825082,-0.0010711844,0.018158462,-0.045599133,0.032681197,-0.0063221734,0.038123768,-0.014619594,-0.037081372,0.047281966,0.003965302,0.0022317492,-0.08572025,-0.07442054,-0.0722856,0.06220003,-0.07541986,-0.058096446,-0.02348516,-0.0026147708,-0.059360255,-0.020376356,0.0061493022,0.015635831,0.07941116,0.040812247,-0.06953208,-0.0666524,-0.072787836,0.02604112,0.05422055,0.051384855,-0.049725603,0.031644423,-0.0004331677,-0.0037431305,0.04649712,-0.040485945,-0.0013405842,-0.0749214,-0.029085875,0.025000965,-0.1342523,-0.03652204,0.06287487,0.04194661,-0.013691385,0.10744531,0.04566328,-0.021830205,0.11976366,0.04170995,0.06932169,0.026647748,-0.06645635,0.009771006,-0.0014865078,-0.008533378,-0.080818854,-0.0065292823,0.009152408,-0.033206467,-0.030507758,-0.055908125,-0.08409043,-0.050328925,-0.03534309,0.046440583,0.05903643,0.018180192,0.00089299737,0.03451511,-0.045673933,0.09663238,0.10274901,-2.381901e-08,-0.0029216784,-0.08569345,-0.0046510817,-0.042216744,0.009791967,-0.01091144,-0.03822355,-0.02514809,0.05612463,0.03890124,-0.04684109,0.009898112,0.06337635,0.068845496,-0.012205699,-0.040847704,0.07179757,0.07644279,0.020128112,0.01885171,-0.07209151,0.038553905,0.03288536,-0.012925569,0.041462116,-0.086286336,0.022917287,-0.06294098,-0.009499863,0.015803587,0.041991815,0.015464054,-0.00309723,0.037376545,-0.0023907123,0.018115606,0.051224157,-0.053799048,-0.09568918,0.04815344,0.058356095,-0.06426479,-0.054157775,0.0023952017,0.037647113,-0.061941154,-0.02517645,0.03454288,0.061883163,-0.055393565,0.01630813,0.016875977,0.019773435,-0.05263367,-0.011826813,-0.021279372,0.010370856,0.024710746,-0.023660092,-0.05709867,-0.051546816,0.010901415,0.14203112,0.036487415 +2.4.1.399,Isolated from the plant Atropa belladonna (deadly nightshade). Involved in the biosynthesis of littorine,384,1.0,-0.039256196,-0.004429061,-0.18115595,0.09350939,0.0398215,0.06797327,-0.066220276,-0.0074852104,0.023090096,-0.012537737,0.06914332,-0.07198927,0.004669796,-0.03960979,-0.09003747,0.07077759,-0.019838268,0.0024980672,-0.0066083684,0.04918234,0.061190195,0.064423606,0.047867954,0.032202527,0.050086945,-0.02422831,-0.068574,-0.027619626,-0.019315483,-0.08014693,0.010048694,0.034374695,-0.010405801,-0.019430645,0.023109829,0.03726355,-0.048316102,4.233117e-05,0.09779876,0.108025156,0.016499512,-0.07946736,0.00076355925,-0.05769878,-0.01654885,-0.006821142,-0.017543387,0.012514653,0.015788944,-0.025120165,0.013148365,-0.028622374,-0.03905572,0.05101884,-0.02933634,-0.090180054,0.08653205,0.047432154,0.007983319,0.0689787,0.099711366,0.06545648,0.00041253728,-0.032464225,-0.08219811,-0.096635655,-0.060883388,0.0068602976,0.09593654,-0.07713373,0.03258558,-0.088922426,0.052871544,0.04493455,-0.09527753,-0.0063154213,0.047032163,-0.0045012482,-0.0364386,0.04377729,0.07648996,0.033771932,0.051976886,0.08541637,0.064275555,0.0041921963,-0.015405308,0.12792052,0.036408763,0.07027707,-0.007901266,0.07063919,0.008640258,-0.0046926625,0.0130754225,0.021272203,0.110091634,-0.069629624,-0.029308144,-0.023543583,-0.02346642,-0.036761295,-0.03754758,-0.038474493,-0.03975494,-0.037883967,-0.03869273,-0.03768103,0.034804754,-0.06966485,0.041161403,-0.0025630668,-0.039892867,-0.004184159,-0.036501244,0.062432695,0.055487495,-0.06729735,-0.077215254,-0.021039478,-0.011936606,0.009763293,0.08093861,0.034161493,0.023700757,0.008241935,-0.043777175,-3.3538358e-34,0.066429086,0.07852949,-0.056716025,0.0012782892,0.037272304,-0.03951057,0.0012763455,0.005431735,-0.07951313,-0.043684263,-0.0712972,-0.070007764,-0.027127089,-0.022252604,0.0031104926,0.020376094,0.021905698,-0.024574231,0.05322153,-0.12467598,-0.03903692,0.060375318,-0.029523324,-0.015446801,-0.04984552,0.0127127785,-0.032205038,-0.054089084,0.0077114925,-0.027755015,0.07169177,-0.048657294,0.009286134,0.04052151,0.07468849,0.033594567,-0.06884266,-0.029904258,-0.04209375,0.0027393661,0.014787933,0.06871735,0.071987055,-0.028352497,0.007052815,0.058743384,-0.05667446,0.00090118084,0.123325884,0.007226877,0.025668692,0.016799228,0.052367326,0.029929163,-0.0817187,0.031099265,-0.044229086,0.020638613,0.12377454,0.083381474,0.029382136,-0.023359373,0.0012295521,-0.027786424,0.042248443,-0.06451626,-0.08416069,0.026488505,-0.06529393,-0.052057926,-0.053285345,-0.050383426,0.06951984,-0.053109046,0.04942267,0.028776601,0.0018228557,0.030985158,-0.055611543,0.015380535,0.0050805095,-0.010442492,0.019051794,-0.031263515,-0.03860683,0.06261187,0.03431032,0.058697976,-0.019794248,0.039128784,-0.0686822,-0.033705667,-0.08754355,-0.05019792,0.04778728,5.426587e-34,0.042243972,-0.047337484,0.0030939337,-0.02936989,0.012085435,0.06681311,-0.1143976,-0.05977897,-0.056860987,0.08982516,0.04733936,0.01632518,0.014589798,-0.02548784,-0.009347929,-0.019601326,0.03615658,0.1046446,0.015292545,-0.020291205,-0.056427117,0.01703713,-0.09757089,-0.084603414,-0.072622046,0.030419841,0.043648586,-0.056245603,0.01815389,0.050531086,0.048216827,0.011026683,-0.071014374,-0.034362476,-0.0051632617,0.116541974,-0.051993653,-0.040135104,-0.004569459,0.07049133,0.049322266,-0.02423104,-0.01113661,0.035447683,0.085896544,-0.009637703,-0.06710461,0.016161364,0.027481763,-0.007655177,0.12289509,-0.023843026,0.04279391,-0.0045820978,0.054633092,-0.09048559,0.016521696,0.024558922,-0.0069045206,-0.10229026,0.036879953,0.016201025,-0.08851123,-0.022264216,0.020674452,0.08297334,-0.049591538,0.04250221,0.003853264,-0.017350866,0.028845089,0.00032547387,0.010609247,0.07462644,0.019908044,-0.06336404,-0.042891573,-0.0255467,0.006994502,-0.017359035,0.04108152,0.00010810949,0.061389107,-0.05928435,-0.016428642,-0.021978509,0.062005028,0.0346533,0.014162999,-0.046897966,-0.024058593,0.051519662,-0.045918643,-0.020470422,0.09086861,-2.1079462e-08,0.033843853,-0.06554779,0.016347956,-0.023178745,-0.028873252,-0.057518948,0.07291643,0.0043223873,0.010532796,0.010924642,-0.040611926,0.011920756,0.06539977,-0.016833024,0.04781885,0.014541585,0.033937715,0.062430613,0.0039084,0.03950691,-0.06031064,0.050076436,-0.0011881936,-0.084122494,-0.023631623,-0.018938689,0.04580055,-0.004808892,0.05893483,-0.03387862,0.12919545,-0.00041996725,0.0025492976,-0.025236575,-0.09104342,-0.011062017,-0.0056544314,-0.07506986,0.011209826,0.015979096,-0.046219602,-0.013467678,-0.0010943316,0.018489368,-0.078789614,0.0361119,-0.016529718,-0.026455723,0.018223396,0.021213062,0.00882268,0.0016625982,0.0467032,-0.046176445,-0.09836485,-0.05066759,0.0756348,-0.024313953,0.015579889,-0.061674315,-0.0065145646,-0.03898823,0.12655383,0.0633071 +2.4.1.400,Isolated from the plant Atropa belladonna (deadly nightshade). Involved in the biosynthesis of the alkaloid L-hyoscyamine (S-atropine).,384,0.99999994,-0.04232989,-0.044768155,-0.16061223,0.072688214,0.042778075,0.088776864,-0.06143203,-0.008009478,0.0129506225,-0.029437672,0.046909317,-0.051244378,0.04219917,-0.0453394,-0.1302758,0.11428344,0.025066167,-0.015876599,-0.008297458,0.0037958282,-0.0017423164,0.12235794,0.032857817,0.05026307,0.05772936,-0.020923285,-0.08781558,-0.038386017,-0.0131767625,-0.06985033,-0.004330469,0.02754363,0.041642044,-0.010678155,0.015730591,0.031852964,-0.058902927,-0.028122688,0.089480884,0.106833264,-0.009436143,-0.03624804,-0.013935717,-0.024054462,-0.058908734,-0.00081124867,-0.021201203,0.023350792,0.045906737,-0.01671682,0.00036024698,-0.04816752,-0.043515746,0.036214095,-0.0649734,-0.06946906,0.056952056,0.084126756,-0.035250377,0.1066775,0.06932088,0.07079005,0.026481189,0.010109891,-0.039884403,-0.06978809,-0.04279559,-0.010844312,0.08807923,-0.060276307,0.020499883,-0.072308764,0.04767045,0.028861055,-0.056011382,-0.0088738585,0.026523484,-0.04866195,-0.058966413,0.017552745,0.07420819,0.01657518,0.07178288,0.09186243,0.006718239,-0.0025563515,-0.04594236,0.14104052,0.043752532,0.041027494,0.022779593,0.022968324,-0.0071620382,-0.017109407,-0.016482707,0.009660999,0.106358215,-0.020970957,-0.04836952,-0.032890126,-0.0054488457,-0.07220529,-0.011084095,-0.017665483,-0.007588052,-0.005838814,-0.040841706,-0.10350911,0.038599312,-0.066694796,0.041308124,0.010208821,-0.04559592,-0.014430379,-0.036887955,0.003748808,0.06057209,-0.062821835,-0.078731626,-0.03446361,0.0113521945,0.015164646,0.078287184,0.0031425671,0.017434917,-0.012485261,-0.072796315,8.835925e-34,0.043177657,0.085835844,-0.027479887,-0.03213217,0.02075637,-0.09486834,-0.01174657,0.00441465,-0.036060415,0.0094215,-0.1003626,-0.026010392,-0.0017001898,-0.030122668,0.02155669,0.03650909,0.015534212,-0.08131528,0.08905687,-0.08464109,-0.050808024,0.06723273,-0.08012363,-0.031960767,-0.05140045,-0.0016796092,0.025765495,-0.008719635,0.0056631034,-0.019055175,0.05928543,-0.09603462,-0.0046331906,0.021512896,0.015687048,0.026749957,-0.050136607,-0.0039627925,-0.023806144,0.0017495644,0.048096843,0.083890036,0.04385559,-0.018653417,0.025669051,0.036610022,-0.045966633,0.012058959,0.05888372,0.02608214,0.029023146,-0.04842935,0.057888992,0.035190735,-0.08776295,0.029229479,-0.038227294,0.017510362,0.0991749,0.13920768,-0.012648257,-0.07977673,-0.0023674048,-0.015762405,0.0119819,-0.09993525,-0.046229232,-0.05085472,-0.07357938,-0.07241348,-0.060230188,-0.028913885,0.07147181,-0.04498305,0.013595124,-0.0032143493,0.023344757,0.028401354,-0.045089573,0.011327998,0.030883154,-0.009663218,0.06024684,0.027154658,-0.030915178,0.025194738,0.042347573,0.046564486,-0.05050231,0.042635307,-0.06274987,-0.06055052,-0.01242022,-0.01924712,0.0753299,-5.509381e-34,0.058734313,-0.061207928,0.023575336,-0.07097577,0.003868032,0.103043854,-0.032752458,0.026780887,-0.055988915,0.06719631,0.021583606,0.02604233,0.031666875,-0.029025951,0.00018203686,-0.04650279,0.01596721,0.13353308,-0.009412748,0.010008994,-0.07488283,0.021597875,-0.051707387,-0.059221845,-0.062398665,0.029100755,0.052402273,-0.048657615,-0.013693373,0.10361554,0.04868009,-0.03467985,-0.045977578,-0.025620786,-0.049666364,0.090041995,-0.06510318,-0.030722853,-0.025087327,0.028768478,0.038508255,-0.0027108944,0.015516754,0.035783216,0.059510715,0.07333126,-0.09329803,0.024928473,0.017901668,-0.059554063,0.0944934,-0.014020434,0.053015232,0.010003833,0.05600917,-0.061723553,0.030330138,-0.013056436,-0.008035393,-0.068787664,0.016888048,0.01898149,-0.08307832,-0.0049151205,0.026300939,0.09415948,-0.05417161,0.010415811,0.0046131266,-0.036712423,0.023787268,0.016179802,-0.002234747,0.10297255,-0.0024740333,-0.043216527,-0.05253749,-0.06514448,0.029301837,0.00473832,0.06905136,-0.0021573051,0.044197567,-0.012665887,0.010919479,-0.057088953,0.07172518,0.08882382,0.034656983,-0.045766864,-0.007830184,0.073828354,-0.07475721,0.011640914,0.11173254,-2.4714083e-08,0.023373261,-0.070989154,0.038602524,-0.010992742,-0.0341632,0.016741805,0.07248927,-0.0031453327,0.037826393,0.015431742,-0.048563126,0.014227907,0.010866448,0.027113901,0.03150154,-0.008442177,0.046341185,0.07718562,0.027799807,0.04182234,-0.071366824,0.08010568,0.024577593,-0.10340882,-0.0063087274,-0.042440858,0.016120344,-0.0029992007,0.0693839,-0.030128766,0.06589627,0.0017163805,-0.023166668,-0.016209062,-0.07701612,-0.028620165,-0.0027451185,-0.033894133,0.0332488,-0.006056705,-0.035049986,0.014422208,-0.0065353857,-0.006210001,-0.06888225,0.005331658,0.0068321927,-0.019411476,0.040613953,-0.0107406005,0.038562693,-0.029947972,0.038247194,-0.08833685,-0.08268546,-0.05448643,0.033159673,-0.06132006,0.0091440985,-0.10646982,0.007139347,-0.036836877,0.10223495,0.0745648 +2.6.1.127,"A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the plant Arabidopsis thaliana, differs from enzymes that catalyse a similar reaction by using spermidine as the amino group donor. The enzyme from Arabidopsis thaliana is bifunctional and also catalyses EC 6.3.3.3, dethiobiotin synthase. cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase, and EC 2.6.1.105, lysine---8-amino-7-oxononanoate transaminase",384,1.0,-0.06484808,-0.05237963,-0.080722615,-0.023899635,0.059875432,0.040087268,-0.089207955,0.06782611,0.038324695,0.059816834,0.06866292,-0.028892484,-0.11250714,0.035230547,-0.009612419,0.041945815,-0.11076675,0.0071598133,-0.007758544,-0.07707468,0.09435155,0.061731275,-0.019729353,-0.017042186,0.06273144,0.011976332,0.006320291,0.005316217,-0.007960754,-0.048533693,-0.063230224,-0.013478379,0.01906371,-0.04782987,0.028831508,0.12831068,-0.06626436,-0.08623226,0.08663226,-0.023218913,0.07562437,-0.0663792,-0.041497324,-0.057113692,-0.09116908,-0.0075900066,0.06088107,0.01025258,0.046597674,-0.041574847,-0.06251226,-0.04913804,-0.0392856,-0.048768952,0.005484232,-0.013380684,0.07583998,0.011946276,0.011000831,0.020096337,0.021231897,-0.018570546,0.003418434,-0.028995255,0.017401103,-0.023803078,-0.0102553405,-0.017790167,0.04250043,-0.074436806,-0.050232686,-0.06552689,0.02898165,0.064132124,-0.029418439,0.055424143,-0.04975978,0.046269797,-0.058993846,-0.010805703,0.00281271,-0.06605298,-0.0064125326,0.043944113,0.03484967,4.0948e-05,-0.040694922,0.04645211,0.06491678,-0.014218802,0.03725524,0.05786087,0.03210505,-0.025208378,-0.03577475,0.090497024,-0.040348392,-0.02815354,-0.03803688,-0.049963806,0.029989531,0.08545,-0.05839683,-0.054101944,-0.021526579,0.061409753,-0.038278475,0.0447244,0.02287025,-0.040081326,-0.065851524,0.03830823,0.0057648877,0.012027526,-0.01806601,0.04609066,-0.028162546,-0.017922467,-0.030755758,0.0518582,0.025892386,0.0014185414,0.061798938,0.09834151,-0.04828192,-0.0043741628,-0.123527326,2.6846932e-33,0.07836876,0.11801511,-0.0024167758,0.0010850286,-0.008968185,0.0015046713,-0.05738761,0.05489912,-0.010852209,-0.07922637,-0.10213888,-0.04679825,0.08041704,-0.05292633,-0.020579113,-0.050636638,-0.06955458,-0.015676646,0.063667275,0.017112115,0.05471356,-0.00035605396,-0.04968136,0.08394194,-0.031785294,0.057448212,0.01672136,7.348849e-05,0.023521217,-0.038756974,-0.033031065,-0.08223807,-0.088198744,-0.052830987,0.043395426,-0.06765667,-0.0331983,-0.06196018,-0.054692276,0.056067772,-0.061006684,-0.021640263,0.024165237,0.0015251132,0.07997862,-0.046570443,-0.042655103,0.08054395,0.05584222,0.10416889,0.022304205,-0.017931402,0.11590667,-0.04569411,-0.07839276,-0.007364638,0.024173936,0.026971193,0.031248461,0.045684583,0.059058826,0.031840354,-0.0032406792,-0.021614183,-0.079408325,0.06386481,-0.05151191,-0.08361243,0.015978323,0.10416591,-0.035071,0.009935627,0.045701068,0.08259951,0.034669787,-0.067940235,-0.06446096,0.008943773,0.0004780174,-0.008739533,-0.014792206,0.010726173,-0.024828825,-0.0049292734,-0.03463576,-0.026813982,-0.023275755,-0.061111916,-0.028846206,0.030795816,0.07761251,-0.057255965,-0.062382914,0.0036328265,0.05235246,-2.057104e-33,0.11928285,-0.052670304,0.009144136,-0.065774776,0.007608887,0.00086163374,0.038903125,0.022612534,-0.02481162,-0.03078314,0.038448982,0.012351152,0.07372573,-0.06130033,-0.00089894736,0.012114409,0.026842779,0.042351384,0.07687399,0.009800688,0.013926002,0.081210345,0.026190588,0.015113854,0.08342739,0.03436503,0.009205069,0.049025424,0.03833445,-0.002523836,-0.0007483997,0.022715762,-0.0024398812,0.017871449,-0.0431832,0.08229991,-0.079407334,0.005772211,0.04072131,0.024570776,-0.002848577,0.056905687,0.03762121,0.053997707,-0.019350922,0.050534774,-0.054965235,0.013218768,-0.035085004,-0.02380942,0.041756388,0.058045123,-0.027442679,-0.0033705053,0.043650974,-0.02239446,0.020504743,0.025543392,-0.020551953,0.013451513,0.0018918873,-0.08577153,0.05557836,0.037774425,0.014826542,0.063055865,0.015277216,0.056155805,-0.004455337,0.054253798,0.09823188,-0.013794757,0.033419203,0.04283523,-0.03128361,-0.02657617,-0.012390382,0.028795922,-0.045872018,-0.06820806,0.001968016,-0.005248913,0.0029527342,-0.080062926,-0.0032235708,-0.02211132,0.054850236,0.10534673,0.02107179,0.031159457,-0.018473493,-0.037005216,-0.009411387,0.072319634,0.1347944,-4.6163777e-08,0.02810996,-0.058215022,0.029906955,-0.06594141,0.07034796,0.02171164,-0.011127411,-0.03876653,0.041078553,-0.049300976,-0.048506014,-0.028245559,0.0102096945,0.04935586,0.038035426,0.02849181,-0.022664431,0.08152374,-0.0010683263,0.037270684,-0.04559129,0.008100431,-0.21498615,0.013836808,0.04593833,0.009081256,-0.048525512,0.007488114,0.021404168,-0.03643736,0.057201315,0.004832593,0.027862554,-0.042552624,-0.09802008,0.06874226,-0.019831814,-0.030452544,-0.057022456,-0.036342833,-0.039949533,-0.029538302,-0.07302233,0.011078153,0.021356156,0.024421565,0.023029486,0.012800363,-0.0013049336,0.028449588,0.08500463,-0.027368076,0.017165193,-0.112485915,-0.117660396,0.0056325425,0.008437146,-0.0418197,-0.005482588,-0.06912051,0.026879694,0.0015937797,0.17890798,-0.028064713 +2.7.7.109,"The enzyme, characterized from the archaeon Methanococcus maripaludis, participates in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor of EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase (also known as [Fe]-hydrogenase).",384,1.0,-0.024802819,-0.03007961,-0.15394409,0.03174384,0.090988256,0.04642022,-0.06444202,0.014234125,-0.015185672,-0.112532414,-0.0290979,-0.06896491,-0.0880511,-0.015681555,-0.098122925,-0.032050826,-0.06594616,-0.030564714,0.040037468,-0.017302617,0.042460248,0.03536985,0.01515342,-0.034093324,-0.024948094,0.012145216,0.020047253,-0.02834517,-0.015526763,-0.00060311536,-0.022903299,-0.02499207,0.10625046,-0.05372497,0.05662099,0.11765616,0.01394715,-0.05615702,0.0509354,0.033161506,0.049621753,-0.020667898,0.010674278,-0.036574423,-0.044448048,-0.035013575,0.06740023,0.009797367,0.014801374,0.008042407,-0.07387619,-0.01254357,-0.046335272,0.012200897,0.025654787,0.01796506,0.032752838,-0.062096212,0.01719047,-0.03440635,0.052072726,0.008468619,0.009442399,0.011518419,-0.02570137,-0.052200884,0.06841588,-0.08137761,0.07712951,-0.09453879,-0.058419723,0.028696954,-0.11245748,-0.07653138,-0.08927764,0.031101573,-0.013166129,-0.085256584,0.08931533,-0.018715052,0.024140067,0.029154,0.011936592,-0.03251988,0.061300382,-0.013089481,0.015293305,-0.01565087,-0.0024703918,-0.0015499619,0.024157953,-0.05782975,0.005176704,-0.037396915,-0.07906165,0.043518722,0.05819145,0.05187348,0.017436748,0.0082194405,-0.056397058,0.03815452,-0.022086238,-0.056359068,-0.07517168,-0.009934239,-0.023656154,0.15015653,0.05712758,0.05992219,0.031813767,-0.016162602,0.04705885,0.03308559,-0.0047035553,0.06468764,0.03439716,-0.064319864,-0.045137957,0.074288204,0.056453057,-0.005852699,0.058339514,0.02672427,0.005895184,0.024446167,-0.12297418,2.7873735e-33,0.0858775,0.039625593,0.024829824,-0.06566575,0.029658562,-0.011044032,-0.12096871,0.019127911,-0.011565438,-0.008860433,-0.021440094,-0.019333474,0.07055273,-0.061139308,-0.09859499,-0.010559059,0.003283106,-0.036966518,0.03196447,-0.0066427873,-0.03593852,0.08529399,-0.01975571,0.005210371,0.001294273,0.053341668,-0.044449396,0.017752012,0.04984598,0.022160776,-0.0029102766,-0.13245335,-0.084080845,0.04203854,0.11118742,-0.030397663,0.008147036,-0.08937982,-0.028371584,-0.062144525,0.0013572427,0.036025684,0.014163615,-0.06615829,0.053142935,-0.020426469,-0.0319453,0.09233527,0.007964126,0.086573035,-0.034751903,-0.0052903276,0.07553757,-0.029229457,-0.09161728,-0.0045480197,-0.02678657,0.01058959,0.051727995,0.097859,-0.041191764,0.07063171,0.027626872,0.07047548,-0.012553602,-0.023602512,-0.015901295,0.024463316,0.0831318,0.121273965,-0.04964993,0.009533748,0.022976128,0.056675058,0.025566649,-0.066789806,0.01625254,-0.07287948,0.051045846,0.015808733,0.0089601185,0.016477618,0.05083925,-0.031502645,-0.051251628,0.031846933,-0.100189544,-0.007246,-0.0061534494,0.025517555,-0.012517235,0.0038996954,-0.018770488,0.044318512,-0.014182135,-3.1133963e-33,0.0575912,-0.10147267,0.045383416,-0.113061175,-0.08758374,0.059374735,0.011421342,-0.021562813,-0.017348219,-0.021896591,0.10972505,-0.044420388,0.04534495,-0.091429695,0.041053373,0.011618471,0.06376608,0.069470875,0.027131757,0.023861233,0.044283632,0.021818057,-0.041580137,-0.026296409,0.027285928,-0.01375138,-0.0076642954,0.021078898,0.043104667,0.05126286,0.017194448,-0.025100557,-0.05398509,-0.092630185,-0.0775238,-0.02701982,0.012865382,0.022773482,0.026819931,-0.0023352047,0.044677485,0.02137126,0.037557963,0.08137671,0.048706193,0.08248806,-0.06545544,0.02748412,0.02003474,-0.018993719,-0.025414659,-0.04492998,-0.06359593,0.006915918,-0.00065456197,-0.007481158,0.10494912,0.04988204,-0.054463647,0.040202007,-0.02490924,-0.042409625,0.05750487,0.03552227,0.07098318,0.07234785,0.004236144,0.0755307,0.054260638,0.016060535,0.08217148,0.048213713,0.0061256574,0.023593714,-0.043542147,-0.036248595,-0.026165364,-0.04137326,0.01792093,-0.02371306,0.05507142,-0.0011048762,0.0030719605,-0.06500052,-0.020583093,-0.10090286,0.062733136,0.083605185,-0.017786622,0.030055914,-0.0441336,-0.005590582,-0.07309528,-0.015257102,-0.004521224,-3.694112e-08,-0.029594908,-0.037639063,0.06948934,-0.07548317,0.023428157,0.044243194,0.043200634,-0.038147327,0.014586968,-0.034048498,0.042446204,0.042571206,0.032440245,-0.027367488,0.0039068446,-0.0054978556,-0.018183066,0.038213234,-0.009017513,0.068062134,-0.013775441,-0.009429829,-0.06649722,0.030954743,-0.050605662,-0.10302534,0.03381343,0.069780335,-0.02877059,-0.04688194,-0.052864812,0.039360557,0.00023209867,0.0059853178,-0.11420825,-0.03477203,-0.05189222,-0.03286948,-0.08386553,-0.0035131264,0.0012149153,0.018842058,-0.035625268,-0.011103376,0.011635323,-0.0085500805,0.0041111046,0.019470906,0.011471083,0.03252062,0.075362265,-0.0036733532,0.07674735,-0.07222562,-0.05302866,0.018145155,0.03374759,-0.08695451,-0.02536701,0.0003203082,0.06569861,-0.04065195,0.1558909,-0.008695625 +2.7.7.110,"The enzyme, characterized from the archaeon Methanothermobacter marburgensis, participates in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor of EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase (also known as [Fe]-hydrogenase).",384,1.0,-0.053991307,-0.0005987876,-0.14986894,0.041069876,0.10711458,0.06335191,-0.09056062,0.046466157,0.0019034814,-0.1101883,-0.029632317,-0.045831785,-0.04991878,-0.061668348,-0.07902009,-0.017842455,-0.060130607,-0.022127459,0.04200183,-0.029458074,0.02942432,0.014704625,0.007894165,-0.03487559,-0.018876132,0.0054818937,0.041352805,-0.021125529,-0.0360482,-0.010020576,0.0006057812,-0.054371372,0.10464347,-0.036879476,0.0522432,0.110096455,0.0016528569,-0.070984736,0.05721436,0.014629195,0.06835879,-0.028045531,0.02647133,-0.051492013,-0.053728186,-0.037811823,0.047840428,0.019581513,0.0019131624,-0.013539252,-0.095931455,-0.045049127,-0.036405522,0.0028020313,0.035616383,0.05795131,0.022325289,-0.07939437,0.037780765,-0.021946143,0.05599022,0.013828988,0.0016039922,-0.009937543,-0.014161313,-0.06922479,0.053473104,-0.08248875,0.08352456,-0.06379945,-0.04513551,0.029042192,-0.10757497,-0.053236276,-0.09722212,-0.004795359,-0.039256237,-0.045075025,0.10466099,-0.012826744,-0.016850404,0.006772914,0.010975904,-0.024950305,0.037923187,-0.008063737,0.0063707894,-0.010044811,0.012549695,0.017998258,0.03700811,-0.06034019,-0.008696053,-0.03365031,-0.11375328,0.056865674,0.07157232,0.05944055,0.0049024313,-0.0014719659,-0.038041845,0.030049318,-0.015044442,-0.07391776,-0.0641285,-0.0034605572,-0.030785475,0.14589135,0.06618685,0.037845302,0.020711,-0.029923184,0.051324584,0.016545074,-0.010017081,0.02624001,0.039632857,-0.06557896,-0.019340845,0.07878927,0.058162473,0.012872743,0.070051044,0.016465487,0.034769624,0.045737553,-0.13376538,3.1523335e-33,0.09963752,0.020624496,0.016194263,-0.045654956,0.031603757,-0.001982059,-0.11510639,0.036615364,-0.033906538,-0.022052128,-0.040372886,-0.04378992,0.06708463,-0.07299802,-0.10601643,-0.014064795,-0.017903207,-0.04918176,0.036816083,-0.010610646,-0.02874844,0.05538963,-0.006140682,0.023366231,-0.0034290731,0.043226343,-0.02794899,0.01820964,0.045302287,0.026618605,0.013100911,-0.119612515,-0.099852756,0.011734188,0.12133519,-0.043284442,0.0069250576,-0.07829447,-0.042576026,-0.03943278,0.009086567,0.034040373,-0.00025143355,-0.057483904,0.074586876,0.008969649,-0.0213726,0.09955885,0.037815057,0.072370104,-0.02900248,-0.018375171,0.09797231,-0.026011921,-0.10462156,0.018542405,-0.00321804,0.025569525,0.059613157,0.096951924,-0.043770373,0.08605446,0.047506187,0.0543667,0.024971081,-0.007168152,-0.0155406585,0.01658304,0.08039019,0.12210125,-0.027545385,0.014539814,0.034739345,0.057224743,0.029208492,-0.0728534,-0.020033153,-0.09093204,0.0506442,0.0066781305,0.00541371,0.0120003335,0.037839793,-0.026012016,-0.039685287,0.011627716,-0.12637243,-0.01009014,-0.00073046447,0.028738903,-0.00063970184,-0.018947093,-0.037127983,0.053034283,-0.02848127,-3.434015e-33,0.041290786,-0.091376014,0.03955405,-0.075608164,-0.054865953,0.0560285,0.0080319,-0.007967526,-0.012933733,-0.023214057,0.12688799,-0.04334037,0.06474981,-0.07866883,0.047752377,0.020082619,0.030314367,0.0638552,0.010539218,0.020825226,0.023152623,0.014985159,-0.03883414,0.0005702368,0.0229061,-0.01662059,-0.015577812,0.046676975,0.044767827,0.065282084,0.04316334,-0.009409385,-0.04522693,-0.106741056,-0.10609968,-0.034190606,-0.005192589,0.02814402,0.06270123,0.0038102411,0.06426754,0.010736881,0.033832233,0.09712061,0.066351674,0.058178697,-0.060393207,-0.001378136,0.0015443419,-0.00501522,-0.040780816,-0.05999383,-0.06396212,0.0023699552,0.001303156,-0.0110261,0.079414286,0.059983093,-0.038646676,0.037855096,-0.039860427,-0.035536695,0.06847469,0.06005933,0.07555228,0.08450093,-0.01233377,0.08644686,0.06214581,0.02177683,0.080717415,0.046735924,0.018292584,0.027860554,-0.006788286,-0.0073134727,-0.026601817,-0.01741644,-0.012922576,-0.0010002124,0.03903643,-0.014068309,0.01197086,-0.07516049,-0.031122377,-0.09540226,0.05953386,0.06977722,-0.020263033,0.04936997,-0.05462052,-0.0010149672,-0.08344481,0.0017002532,-0.012326092,-3.7248107e-08,-0.03144241,-0.041913737,0.058343053,-0.07390695,0.03515757,0.026561905,0.025630891,-0.03736537,0.015196324,-0.01880182,0.0137036545,0.033642568,0.020628316,-0.017029751,0.023167424,0.0008110636,0.0014511305,0.03207169,-0.015229196,0.06714324,-0.01226983,-0.014764746,-0.05150762,0.029328447,-0.016286867,-0.10379234,0.008543381,0.052865773,-0.019151157,-0.04523942,-0.046716206,0.052542526,-0.002462294,0.018761968,-0.11076659,-0.01277087,-0.05778616,-0.046841983,-0.05178304,-0.014841668,0.0016705187,0.026762065,-0.05422371,-0.013747129,3.882966e-05,-0.011228835,0.019878937,0.015821336,-0.012340073,0.0055288663,0.050539557,-0.01938978,0.054137424,-0.06851569,-0.04913968,0.027562957,0.03820297,-0.08997154,-0.035563245,-0.015545933,0.052790776,-0.035739597,0.13687855,-0.014035046 +2.7.10.4,"Requires Mg2+. Specifically phosphorylates a C-terminal tyrosine in Src family of non-receptor protein kinases (Tyr 527 chicken c-Src numbering, Tyr 530 human c-Src numbering) [1,2]. The enzyme engages in particular binding mode with its substrate proteins to present the C-terminal sequence in the active site. A shortened activation loop disrupts the conventional substrate peptide docking observed in most tyrosine kinases [1]. It can be activated by docking of the SH2 and linking regions to the kinase domain [3]. Removal of the SH3/SH2 domain decreases kinase activity by 100-fold [4]. Phosphorylation of Ser364 by cAMP-dependent protein kinase (EC 2.7.11.1) activates the enzyme in the presence of the Csk SH3 domain [5]. The SH3 domain lacks a tyrosine for autophosphorylation in its activation loop and requires a specific binding mode to its substrate proteins for catalysis 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+3.1.1.124,"The enzyme, which has been studied from the fungus Aspergillus niger, catalyses a step in the degradation of ellagitannins such as punicalagin, which are phenolic compounds occurring in pomegranates and some tropical trees. It hydrolyses ester bonds between the D-glucose core and the hexahydroxydiphenic acid groups of ellagitannins, releasing hexahydroxydiphenic acid that undergoes spontaneous lactonization to form ellagic acid. Unlike EC 3.1.1.20, tannase, it does not act on gallotannins. More recent studies suggest that the activity may be catalysed by EC 3.1.4.3, phospholipase C 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+3.2.1.229,"The enzyme is an endo hydrolase that cleaves after the GlcN-GlcNAc diad in partially acetylated chitosan with subsite -2 specific for GlcN and subsite -1 specific for GlcNAc. The enzyme does not cleave fully deacetylated chitosans which are cleaved by chitosanases (EC 3.2.1.132) and glucosaminidases (EC 3.2.1.165) or fully acetylated chitins which are cleaved by chitinases (EC 3.2.1.14, EC 3.2.1.200, EC 3.2.1.201, EC 3.2.1.202) and N-acetylglucosaminidases (EC 3.2.1.52). The protein was found in the medium in which the plant pathogenic fungus Alternaria alternata was grown.",384,1.0,-0.060409494,-0.11149303,-0.06340788,-0.061177384,0.071009405,-0.023140568,-0.024339464,0.030702002,-0.0024007955,0.061352596,0.10603951,-0.0066372296,-0.03976447,0.059598673,-0.1519978,-0.00167083,-0.028971866,-0.042219725,-0.026693799,-0.043760527,0.087336436,0.021657571,0.0078078215,0.009945907,0.016763896,-0.045436043,0.001305218,-0.012129213,-0.023677902,-0.08202053,-0.04127329,-0.05165485,-0.011879541,0.03986398,0.01850219,0.06679017,-0.033568297,0.016775593,0.054122012,0.054614376,-0.018887449,-0.04627821,-0.023838425,-0.024806907,-0.03208919,-0.055990778,-0.10260019,0.027104517,0.039751176,0.016278133,0.007260551,0.0048286323,-0.045700677,0.01174679,0.030619824,0.05068637,-0.045235876,-0.11371332,0.05505788,0.1172377,0.0559788,0.016458943,-0.048156966,-0.04509957,-0.029240085,-0.055782843,0.030452343,-0.061201956,-0.0034655405,-0.024078062,0.023562124,-0.058255322,-0.091274805,0.030606907,0.008948123,0.0007400378,-0.046873573,0.010359456,0.009264457,-0.046183646,0.019500418,0.042521965,0.030950563,0.07671206,-0.007981086,-0.039524682,-0.039784253,0.06557765,0.09667396,0.036371388,0.04930284,-0.012896977,0.0021509402,0.018952807,-0.01770544,0.018448016,0.06754496,-0.003084238,0.067070246,-0.0040193303,0.0119742025,-0.00851918,0.025339305,-0.09759814,-0.06564065,0.025402358,0.05515421,0.09705227,0.063099384,-0.005617699,-0.015785826,0.063086376,0.0010020233,-0.06767998,-0.07514516,0.09124651,0.030158086,-0.022772472,-0.024344603,-0.005432188,0.0026863227,0.042255837,0.033976898,0.055794742,-0.0045414474,0.07044238,-0.051029004,4.4518862e-33,0.022569468,-0.021840591,-0.0030685775,-0.00546878,0.013490346,0.019565146,-0.04571117,0.01793968,-0.024795786,-0.07753769,-0.07241865,-0.0027469234,-0.08505823,0.049462974,-0.010587785,0.06808995,0.045475017,-0.0434776,0.007506012,0.036440223,0.036763694,0.08283213,-0.053328384,-0.03150812,0.08793832,0.019748779,-0.04249696,0.018150304,0.059857342,-0.018071301,0.039636154,-0.0062694796,-0.03790978,0.03349923,0.078981586,0.023429772,0.021069609,-0.033133745,0.024923638,0.04204839,0.07161515,0.0672136,-0.012691552,-0.042662445,0.044207904,-0.04605592,0.01682041,0.051596515,-0.02450765,0.010786086,0.047294535,0.025098735,0.057357986,0.04531289,-0.030570043,0.033506043,0.00822891,-0.0076731867,0.14024647,0.011177661,0.037833687,0.040160008,-0.023446195,-0.024471566,0.019177204,-0.016456088,-0.079297096,-0.03624712,-0.0066796965,-0.02064962,-0.039039515,-0.041431576,0.0046923948,0.02538468,0.054763354,-0.08104673,-0.08464995,0.052200954,-0.058757678,0.011105577,0.0915432,0.04931787,0.009715861,-0.0021713816,-0.0684865,0.0059764762,-0.0031654001,-0.07517106,-0.027037112,0.0007312268,0.027893558,-0.040278163,-0.00820965,0.01849856,0.0241636,-4.2278274e-33,0.119764276,-0.12297815,0.03242098,-0.0014776167,-0.017723668,0.041999403,0.019273413,0.016475124,-0.036920436,-0.06249974,0.07029863,-0.004228237,0.025598729,-0.023064466,-0.012676452,0.009899777,-0.014831739,0.10244108,-0.018451719,-0.00021051457,-0.07244097,0.08739635,0.023382442,-0.04553781,0.10838225,-0.017647218,0.02998714,0.09101345,-0.06674281,-0.00045280834,-0.047925044,0.0022790716,-0.051498134,-0.024864342,-0.04932206,0.02101199,-0.03065979,-0.046340767,-0.03205043,-0.022476569,-0.030048747,0.023815716,0.02967425,0.02462936,0.02160109,0.08591185,-0.032424446,-0.03463305,-0.029898869,-0.054979853,0.04354657,-0.033676673,0.008084235,0.054400634,0.061358955,0.028172353,0.039016955,0.07394351,0.037961286,-0.032168325,0.005642345,0.015349968,0.008023431,-0.009284678,0.07328827,0.089092255,-0.07090301,0.085792676,0.01433464,-0.0321341,0.02047628,-0.012458374,0.05222746,-0.005030003,0.05381638,0.04973965,-0.076751605,-0.047217004,-0.06409697,-0.081345454,0.04055058,-0.042057328,-0.035164103,0.002253328,-0.05364226,-0.045785937,0.07310506,0.102015406,-0.14200984,0.06207369,-0.0077536143,-0.0584963,-0.043666955,0.07511403,0.120763645,-4.3383576e-08,0.004360341,-0.04081321,-0.027062407,-0.14574167,0.042330246,-0.019743273,0.027454754,0.011042281,0.07636458,-0.030443048,0.010261618,0.086066626,0.018131685,0.074302234,-0.050777238,0.009318201,0.05263696,0.049720265,0.020528113,0.055944793,-0.041198235,0.070493124,-0.11822294,-0.010654169,-0.044999037,-0.07325878,0.03754495,0.09234738,-0.032879695,-0.059978288,-0.029396942,0.03649831,0.042923145,-0.090329684,0.0089643635,0.038290016,-0.09225371,-0.033160664,0.027757693,-0.011076286,0.03706499,0.01741421,-0.02462005,-0.04498172,-0.04513996,-0.08440215,-0.024887273,0.05541487,0.0108500635,0.066462025,0.06562114,-0.021708973,-0.011040927,-0.13541229,-0.066036284,-0.080924496,0.024652706,-0.0621454,-0.0266251,-0.030986113,-0.05673302,-0.07573704,0.12421403,0.01594082 +4.2.3.230,"Requires Co2+ or Ni2+. The enzyme has been characterized from the cyanobacterium Nostoc punctiforme and the Gram-negative cellulose degrading bacterium Sporocytophaga myxococcoides. cf. EC 4.2.3.124, 2-deoxy-scyllo-inosose synthase",384,1.0,-0.08914178,-0.010446806,-0.13380323,-0.0022481387,0.04131891,-0.019288337,-0.06465915,0.049389083,-0.019729516,0.06713011,0.009260595,-0.11174995,-0.047677185,0.066284314,-0.082986124,0.038947456,-0.009405329,0.02584106,0.058590744,0.0037032086,0.06328682,0.07229329,-0.06069045,0.013894748,0.04925947,-0.007857682,-0.043286186,-0.04111181,-0.040529847,-0.03250258,-0.048044987,-0.014973654,0.08223957,-0.09353212,0.14123504,0.057160016,0.026493289,-0.05713375,0.102203935,-0.035153225,0.040436063,0.022385884,0.027908303,-0.006171775,-0.030062815,0.038127303,0.046318103,0.032816183,0.024972193,-0.06241737,-0.08201793,-0.014456707,-0.043483697,-0.0073362472,0.017446844,0.02895548,-0.07483378,-0.016372724,0.037913688,0.039828286,0.052467264,-0.043385576,-0.004496479,0.029202722,0.036083937,-0.11784112,0.03392058,-0.05405797,-0.030126669,0.026133686,-0.053546444,-0.051330898,-0.056011688,0.05075038,-0.027321773,0.09376818,0.043841433,-0.060648333,0.009438797,-0.0021460403,0.045018896,0.013610606,0.048355848,0.034812797,0.04748465,-0.03656414,0.053164482,0.050221864,0.028086808,0.042762283,0.049187936,0.0021045592,0.017150953,-0.022392845,-0.06763182,0.026734717,0.043691535,0.1115173,0.010296408,-0.021263178,0.0078964885,-0.030064782,0.05542427,-0.08435563,-0.016146628,-0.032911044,0.02541311,0.08404942,0.08722939,0.0545908,-0.016361129,-0.0004882935,-0.01765926,-0.05743961,0.02422672,0.09776158,0.051550914,-0.032914456,-0.061906997,0.022170773,0.0048100543,-0.038882308,-0.036942344,0.05538718,-0.11884501,0.071923226,-0.061527606,4.478212e-33,-0.01206562,0.04103625,0.016057376,0.008622429,-0.069191284,-0.08806148,-0.07237344,-0.01587846,-0.057278316,-0.04148661,-0.042986456,-0.05693383,0.047320884,0.066233106,-0.068628594,0.04495785,-0.015930686,-0.07460162,0.045191873,0.037063327,-0.042904187,-0.016095197,-0.06401679,0.020839283,0.09965634,0.0581396,0.01469412,-0.09400312,0.039845824,-0.037225068,0.08665251,-0.07341119,-0.11296128,0.03330236,0.10083673,-0.04552149,-0.0038916422,-0.013520551,-0.029290885,0.026040142,-0.060471434,0.024350077,-0.01843674,-0.027873848,0.06258137,-0.000781476,-0.023850627,0.06933791,0.007873286,0.043595057,0.0492943,-0.0020877665,-0.0014673006,0.034793776,-0.06789681,0.060545675,0.09338134,0.012834857,0.095362306,0.020593075,-0.04007435,0.051822823,-0.05001229,0.030099047,0.0052407593,-0.020233516,-0.08323262,-0.041043404,-0.00655812,0.0044401996,-0.11506653,-0.06433364,0.04578202,0.005095726,0.05037718,-0.06332051,-0.07734213,-0.04228717,0.059505533,0.0042280606,0.04297759,-0.03846355,0.0036548488,-0.07868522,-0.021646045,-0.04277106,-0.094103165,0.022107955,-0.013249642,0.019739278,0.048050668,-0.07905311,-0.071755975,0.027752513,-0.025307622,-6.1590353e-33,0.06276228,-0.03605872,0.021895688,-0.07376153,-0.06964947,0.06988763,-0.020032546,-0.07583611,0.06882369,0.0014815814,0.08539638,-0.021728972,0.041392125,0.016189558,0.010390347,-0.008552929,-0.053301767,0.037833758,-0.021778122,-0.043677792,-0.0016437386,0.12783106,-0.0041753734,-0.024777204,0.020668948,-0.013196842,-0.01055201,0.08961029,0.08398508,0.018450646,-0.08274032,-0.0049199355,-0.02608058,-0.026246317,-0.04203453,-0.016671263,-0.018810395,-0.020505633,0.0010767851,-0.007882149,-0.017965447,0.082284346,0.007879984,0.102533266,0.02928446,0.05300852,-0.08284766,0.017564246,-0.018523296,0.024791814,0.014602629,0.037232872,-0.060196403,-0.03356044,0.019549018,0.010442718,0.022637842,0.0031290497,-0.021728551,-0.061951194,-0.0436292,-0.04625888,0.04372615,-0.015920212,0.073713385,0.07779583,-0.08215423,0.09311996,-0.014206883,-0.02131202,-0.0026725458,0.020478241,-0.043884896,-0.031096637,-0.06897711,-0.04558809,-0.058949284,-0.0040741856,0.041216947,-0.057369124,-0.003635934,0.0015283384,0.07774,-0.010360919,0.10099044,-0.030122291,0.021022549,0.0693967,-0.015588911,0.029127304,-0.0024459825,0.023955042,-0.031690385,0.0674741,-0.002488053,-4.258842e-08,0.01648655,-0.041624896,0.046749532,-0.06252198,0.06035771,0.041993145,0.02589155,0.003639323,0.11876688,-0.009372059,-0.009185991,0.07201481,0.0185202,-0.020431736,0.016725233,0.051387567,-0.056999523,-0.08172096,0.0066612144,0.015909605,-0.010420885,-0.04535865,-0.11287816,0.11656793,0.017660143,-0.057326667,0.045710213,0.07852647,0.0020840338,0.00027553097,-0.050721005,0.05357948,-0.039824083,0.002249755,-0.0879211,-0.02560262,-0.03139183,-0.0730916,-0.011240236,0.0014860485,-0.0074762516,0.029565314,-0.06584684,-0.011815154,-0.018430289,0.045261033,0.018675297,-0.038183566,0.020569209,-0.01156007,0.007459977,-0.0017611333,-0.039390143,-0.019541671,-0.05493653,0.072806396,0.020931344,0.029258737,-0.069465384,-0.0192487,0.00425367,0.0042901924,0.1578116,-0.034762744 +4.4.1.44,"The enzyme uses radical SAM (AdoMet) chemistry to catalyse thioether bond formation between pantetheine and C-2 of the carbapenam precursors (3S,5S)-carbapenam-3-carboxylate or (5R)-carbapen-2-em-3-carboxylate, leading to formation of complex carbapenems. Contains a bound [4Fe-4S] cluster and hydroxocobalamin.",384,1.0,-0.075660005,-0.06804767,-0.1128548,0.055513166,-0.034902927,0.08376551,-0.09061051,0.07524751,0.058556464,-0.065161474,-0.017767869,-0.053949263,0.004850123,-0.019635595,0.013733551,0.02671605,-0.03020522,0.0398152,0.02328492,0.020144131,-0.0045000743,-0.0080089625,0.0032041739,-0.035637934,0.05559345,0.074190505,0.11389807,-0.053825006,0.0076111048,-0.032561086,0.04549095,0.0017493578,0.054815307,-0.06584297,-0.00865344,0.061429724,-0.06395089,-0.07435863,0.096866116,-0.04239801,0.020163221,0.07450745,0.032504484,-0.09427297,0.02050363,-0.016724532,0.0055499384,0.041335404,0.02024275,-0.04908366,-0.04519403,-0.02496071,-0.062856175,0.022649065,-0.03711341,-6.436108e-05,-0.019669151,-0.060353134,-0.016063876,0.061296426,0.096433826,0.03199347,0.008822705,-0.012089428,-0.014347218,0.0048793955,0.043443635,0.0008041038,0.039323468,-0.008826905,-0.06926136,0.0021240604,-0.010034053,-0.018144708,-0.016369766,-0.014996,-0.026143914,-0.022410234,0.06122586,-0.068715714,-0.017402463,0.0067878705,0.03329958,0.14307217,0.0324161,0.010975507,-0.00078130694,0.044956412,0.020348884,0.06897371,0.033430386,0.070976324,-0.034321927,-0.040531456,-0.07692993,-0.013757612,-0.011972029,0.06886834,-0.0043445346,-0.036202304,0.066757254,0.05887473,-0.036748696,-0.09383472,-0.0006118846,0.050921507,-0.03191415,0.06949877,0.019754507,-0.016261727,0.010986958,-0.014095991,0.034280095,-0.065826744,-0.11349949,0.05931935,0.026446272,-0.1000364,-0.039393608,0.032764424,0.05357485,-0.05790258,0.03850767,0.0034134125,-0.037354823,-0.026462672,-0.0661471,3.2817525e-33,0.021520723,0.0422354,0.067178704,0.029636426,0.017446414,-0.022006875,-0.079833604,0.036349233,-0.0509566,-0.015674846,-0.097943015,-0.013108306,0.029827751,-0.069558166,-0.021499604,-0.042573303,-0.09265493,-0.025013585,0.05953093,-0.061048947,-0.039309874,0.040041577,-0.04350352,0.023959687,-0.001877565,0.08828981,0.08623749,0.0021795437,0.039497126,0.02055702,-0.0055799666,-0.03092116,-0.13059197,-0.06467386,0.023594588,0.036424648,-0.025659809,-0.04264399,-0.04734509,0.034889616,0.0863106,0.018199852,-0.0044888896,0.010345451,0.016025748,-0.031308547,0.00314647,0.059969317,0.07694214,0.067383945,0.035896894,-0.092337996,0.050924465,0.103963785,-0.029022502,0.03799047,-0.061958883,0.05032786,0.035581928,0.07378688,0.025978355,-0.022166396,-0.07556101,0.03841856,-0.060054015,0.054899536,-0.053840827,0.0023416246,-0.036732063,0.079488076,0.00821718,0.021780297,0.07867417,0.046619717,0.046358865,-0.03412352,0.007887248,0.010664159,0.031430904,-0.047833372,0.018500984,-0.031949207,0.05533714,-0.011887341,-0.06306497,-0.048148364,-0.0029848928,0.015121569,-0.06068582,0.03318727,0.022433912,-0.047654156,-0.017454505,0.041895166,-0.042726472,-4.180481e-33,0.028013995,-0.1170585,0.027219594,-0.047337,-0.035078682,-0.0022132064,0.01739489,-0.048626993,0.023268705,0.012320688,0.079056755,0.012468031,0.1021944,-0.055359755,0.024881892,-0.022338059,0.06165124,0.033892453,-0.052533083,-0.0740985,0.01537349,-0.010794144,0.004980092,0.023951212,-0.02219737,0.03624884,0.026216162,0.0097322855,0.050649017,0.16903141,0.13231452,-0.059881072,-0.061153688,0.0077003385,-0.10822795,0.069174126,0.02381599,0.009227744,-0.012620033,0.04173361,-0.036509786,-0.05025195,0.0065076575,0.075706,0.06719348,0.047239773,-0.08810359,0.04621485,0.022728914,-0.046121716,0.10332502,-0.04423767,-0.006498245,0.0028359185,-0.025475595,0.039769124,0.02582716,-0.07175662,-0.0031545383,-0.06325523,-0.03749867,-0.03611204,0.06183781,-0.07117569,0.015030145,-0.0039227954,0.0038757217,0.09993767,0.03791926,-0.009605308,0.006148842,0.06540688,-0.02965653,0.01397046,-0.017753499,0.06526127,-0.039521232,-0.055731773,0.012101404,-0.026764475,0.016720543,-0.041247528,0.025147168,-0.066473074,-0.07651243,-0.033459205,0.06065452,0.1370921,0.015202613,0.021606252,-0.09228944,0.037810527,-0.019709066,0.06296254,0.023062631,-4.022719e-08,0.0061606327,-0.090155214,0.0032252672,-0.020456748,-0.038908787,0.0733351,-0.07029433,-0.0066119046,0.031088956,-0.056758232,-0.012522365,0.029009998,-0.075653315,0.058987055,-0.0007660181,-0.025116464,-0.0028751693,-0.007313267,-0.03645782,0.0035422957,-0.07980305,0.013166957,-0.005977141,-0.05766201,0.051702376,-0.09118435,0.009199575,-0.021350473,-0.029521953,0.0111411745,0.010942357,0.052003972,-0.07243854,0.02404098,-0.10231009,0.0148356175,-0.05017013,0.0024161688,-0.042574648,0.064756766,0.03061751,-0.06069625,-0.1462554,0.026920177,-0.04331618,0.018681183,-0.009861044,0.034002457,-0.050280243,-0.025138557,-0.033258412,0.010671567,-0.062980674,0.01124105,-0.048923682,0.025498804,-0.019891828,-0.055722836,0.041139964,-0.087529235,-0.027675753,0.036420405,0.12487165,0.09268905 +4.4.1.45,"This enzyme, found in the bacterium Thermotoga maritima, catalyses two complex reactions during the biosynthesis of a nickel-pincer cofactor. The process starts with the adenylation of pyridin-1-ium-3,5-dicarboxylate mononucleotide (P2CMN), which is covalently bound to an intrinsic cysteine residue. Next, a [4Fe-4S] iron-sulfur cluster receives a sulfane sulfur from free L-cysteine via the action of EC 2.8.1.7, cysteine desulfurase, forming a temporary [4Fe-5S] cluster. The sulfur atom then attacks the activated substrate, resulting in formation of pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide (PCTMN). The process repeats twice, with pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide (P2TMN) being the final product. cf. EC 4.4.1.37, intrinsic cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase.",384,1.0,-0.0598395,-0.048059054,-0.07812989,0.029685564,0.07030686,0.047131278,-0.061110213,0.027742583,0.03129314,-0.03497392,0.035536963,-0.03193102,-0.05477713,0.03426228,-0.08494931,0.01638416,-0.053835053,0.037201423,0.012282541,-0.045443386,0.02870982,0.0015201872,-0.036564406,0.02420332,-0.06423846,0.11760488,0.05613477,0.0013150827,-0.09981213,-0.032413177,-0.04643678,-0.08461846,0.055306967,-0.0034557357,0.043775897,0.12550664,-0.0408989,-0.020050174,-0.005029478,-0.064991795,0.0028883957,0.013292093,-0.004245174,0.019402103,-0.0029009476,-0.025540669,0.024358226,0.062363148,-0.008248426,-0.057979666,-0.0077553093,0.022842709,0.039515667,0.0328173,0.021140207,-0.011020903,-0.010137455,-0.023185497,0.000104078805,-0.06655501,0.08457419,-0.023365268,-0.016218819,-0.06912787,0.021628117,0.009818343,0.04695529,-0.08418367,0.02497691,-0.045325093,-0.042725462,-0.0014923017,-0.053297795,0.01122879,-0.022724763,0.10103255,0.0040230295,-0.078790314,0.035696182,0.042068396,0.010258608,0.013892295,0.04507247,0.027082449,0.012346539,-0.054952927,0.023103034,0.034178644,0.043012578,-0.0013106248,0.026414083,0.06850796,-0.06432739,0.002020969,-0.07712496,-0.00037920746,-0.017707737,0.14646411,0.061521117,-0.026830625,0.031520493,0.08263874,-0.10145528,-0.12320437,-0.02984052,-0.044006865,0.027427297,0.14076959,0.0191056,0.032141097,-0.010646906,-0.014821084,-0.0061649554,-0.005494994,-0.033821933,0.12871173,0.07350913,-0.021110112,-0.08036976,0.053464312,0.05401498,0.013007534,0.010824574,0.08969755,-0.028378943,-0.0028029487,-0.20600106,3.6981552e-33,0.06255947,0.0431854,0.05084173,0.02269761,-0.016559506,-0.038014457,-0.08540226,0.023279274,-0.03739064,-0.01986365,-0.03555134,-0.029005183,0.072542846,-0.1023061,-0.08163138,-0.04569881,-0.05136523,0.014561525,0.07702393,-0.003261261,0.00766777,0.040896676,-0.034456298,-0.0062359013,-0.018001057,0.10835625,0.013732946,-0.0169477,0.037709225,-0.006548889,-0.014898528,-0.10040265,-0.093472466,-0.050378527,0.1425149,-0.05359193,0.013262662,0.007975352,-0.010048694,0.02440162,-0.042668458,-0.014145935,0.05149749,-0.059683386,0.05488029,-0.070962824,-0.0851176,0.08030833,-0.014723189,-0.006399265,0.04401384,-0.032038145,0.112058446,0.027603805,-0.068103515,-0.0077306796,0.019131383,-0.020629905,0.046003807,0.04292952,0.048390552,0.048648894,-0.075134635,0.0034962948,-0.0004120703,0.0019277331,-0.003933988,0.045201316,0.00024365663,0.13867415,-0.01988279,-0.008390077,0.053521007,0.034396622,-0.037970442,0.005771945,-0.030821286,0.011826771,0.017923933,0.049741693,-0.08874162,-0.018999655,-0.034829564,-0.013143227,-0.03760534,-0.03461913,-0.04287504,-0.02129278,-0.059308317,0.024791013,-0.033734925,-0.024814842,0.007837122,0.017568754,-0.030843988,-5.5917183e-33,0.07307536,-0.05990759,0.016220927,-0.07830468,-0.040822335,0.049309753,-0.01856044,-0.03413278,0.032681763,-0.007775359,0.07488032,-0.017140647,0.038498987,0.021103159,0.009758263,0.05004934,0.04604142,0.07496458,0.013445199,0.015168681,0.035889648,0.04959941,-0.015736818,0.02205315,0.028784594,0.007485834,0.05099087,0.0213121,0.048342813,0.101645425,0.0061633545,-0.011536746,-0.013448257,-0.076934464,-0.01954564,0.047780395,-0.034379166,-0.035982396,0.07171174,0.010700039,-0.001909702,-0.02687803,-0.02663306,0.12139964,0.035975046,0.0075637726,-0.03887738,0.040507764,0.010946734,0.043286595,0.040942676,-0.036119677,-0.042222053,-0.02200298,-0.015603571,0.053791754,0.01444586,0.02455122,0.019874008,0.028173601,-0.049003553,-0.12509346,-0.0067178505,-0.05456319,-0.026406765,0.018954247,-0.012221516,-0.025066596,0.05962751,-0.0066140117,-0.02331007,0.057168834,0.006113232,0.016512556,-0.06546267,0.011198255,0.011760837,0.09330146,0.017042097,0.032168556,-0.0050862697,-0.010359648,0.034983736,-0.09334791,0.10600871,-0.11761483,0.05647174,0.10757512,-0.059810933,-0.015484464,-0.04072966,-0.01913632,0.028411338,0.027092041,-0.1031763,-5.0784912e-08,0.010959792,-0.07962818,0.032844093,-0.050408404,0.0019785506,0.07351555,0.0182589,-0.051607538,-0.020497544,-0.01868496,0.096144065,0.06022009,-0.03533445,0.02436834,0.046620186,-0.0062374906,-0.04551061,-0.0040512215,-0.015286506,0.020142043,-0.04344893,-0.028333688,-0.12875648,-0.02124935,0.001994284,-0.089144416,0.048392653,-0.060718987,-0.087104715,-0.034487806,0.03064198,0.0064671054,-0.03199137,0.017242543,-0.042143553,0.021113029,-0.096525125,-0.005874781,-0.01912919,-0.022537762,-0.0182201,0.025181442,-0.093781374,0.034902774,-0.009323144,-0.022357112,-0.030817542,0.067745544,-0.046748765,0.06851561,0.025310913,0.0023062332,0.0054279678,-0.047791272,-0.032286014,0.062373508,0.076047584,-0.09155437,0.03026977,-0.0056393547,0.050788477,-0.041271355,0.07708765,-0.025356354 +6.2.1.77,"The adenylation domain of the enzyme catalyses the activation of L-lysine to (L-lysyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein (as in the case of ScoA), or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.",384,1.0,-0.00060632173,-0.12492552,-0.0766581,-0.053630855,0.06170772,0.052488953,-0.040666245,0.0329296,0.10139885,0.02412161,0.04419706,0.00090579636,0.049954273,0.043817665,0.04936484,0.024049072,-0.123234324,-0.05115145,0.0022067209,-0.0651004,0.07495703,0.07331679,-0.042849567,0.08356491,-0.011365503,-0.043901578,0.007999412,-0.0029660265,-0.011367377,0.015782688,-0.012470765,-0.024673881,0.007175654,-0.01983127,0.03467211,0.084414884,-0.056111105,-0.02588383,0.07744879,-0.011801648,0.024851823,-0.07196475,-0.033309825,-0.021239914,-0.034071777,0.049896203,-0.002036831,0.11445158,0.02079274,-0.016558252,0.01362367,-0.107090466,-0.066562235,-0.031383153,-0.11480923,0.09879937,-0.101525724,0.039816927,0.043653797,-0.0037428243,-0.062096372,0.032089874,0.016146585,0.036416978,0.059241846,-0.12051741,-0.011745855,0.004605734,0.004713211,0.005937172,0.024665803,-0.108621426,0.015397408,0.07323947,0.08931794,-0.02223312,-0.019113865,0.027679434,-0.04840997,-0.022788292,0.056883875,-0.014149229,0.013560142,0.05846876,0.013902068,0.022483934,-0.00061453064,-0.025018577,0.020574631,-0.048140623,0.068492495,-0.120047644,0.023481136,-0.019141812,-0.035688028,-0.033635963,0.021999156,-0.04692115,-0.04304992,0.013185558,-0.0052274424,0.02027019,-0.03462481,-0.04303394,0.004708547,0.046316117,-0.015885148,0.09092737,-0.04698162,-0.034048386,0.015414255,0.027059918,0.0892583,-0.03406135,0.027634768,0.074294,-0.045306705,-0.05509547,0.016116112,-0.085053265,-0.0050158063,-0.03715001,0.03183001,0.089644365,-0.06092116,0.040454045,-0.0670917,1.3906182e-33,0.04764037,0.009892136,0.06533119,-0.019797342,-0.06742553,0.016121881,-0.040447228,0.024727138,0.028527113,-0.016225707,-0.079808705,-0.010963129,0.042655967,-0.030051468,0.011435133,0.0017333005,-0.08805438,0.06824122,0.07189271,0.09655412,-0.090737335,0.036993045,0.00944903,0.041832596,0.033970077,0.0162163,-0.037284404,-0.092812434,0.042472817,0.026838578,-0.065037765,-0.010463566,-0.06356894,0.011660454,-0.036600064,-0.0076197893,-0.013139342,-0.06328893,0.044951297,0.020902617,-0.013382498,-0.045285884,-0.014223501,-0.030394664,0.013850757,0.013737175,-0.014113949,0.055562332,-0.11295221,0.022444298,0.0819507,-0.057496786,0.10140163,-0.057476893,-0.05228836,0.017611558,-0.023567285,-0.07297719,-0.007882887,0.059623465,0.05494532,0.04241272,-0.0015117412,-0.009946902,-0.046509627,-0.018504271,-0.0639215,-0.12598132,0.013329213,0.087953866,-0.03056805,0.080300756,0.08899569,0.05078606,0.020383168,-0.027948089,-0.061454352,0.039775144,-0.026235633,0.07765368,0.01853022,0.0042890483,-0.06295468,0.032120656,0.054868333,-0.06262031,0.051477097,-0.08614502,-0.073871255,0.0059117815,0.0026013986,-0.055592943,-0.027393391,0.10055053,0.01123544,-2.6080805e-33,0.04659562,-0.14743023,0.035290316,-0.026780238,-0.074347906,0.0041211653,0.045700423,-0.04521852,0.032928742,0.0008658085,0.028151225,0.0043856488,-0.07320772,-0.07496926,0.06484675,-0.03091776,-0.044902407,-0.027634399,-0.033115715,0.013964524,-0.0113249365,0.0028855586,0.032148648,0.05629232,0.040356584,0.0039286013,-0.07734268,0.09990519,0.06173642,0.0106681455,-0.01525952,-0.06299791,-0.047421686,0.001112358,-0.048113223,0.07534024,-0.024338119,0.049149908,0.074712574,-0.015939632,0.03281834,0.05468084,0.008448296,0.04681152,0.024324698,0.10021128,-0.02092864,0.046236295,0.023496043,-0.09394385,0.044191986,-0.059259884,0.065012224,-0.006574742,0.012466676,0.06187631,-0.0001116954,0.052603144,-0.048377786,-0.027373422,-0.036283694,-0.06033203,-0.06894593,0.05540424,-0.018526908,0.0034594426,-0.05806306,0.04019178,0.025980053,0.025019493,0.03740747,-0.026740978,0.043936923,0.024451729,0.001958359,-0.010244707,-0.05719213,-0.12470905,-0.0350321,-0.07324482,-0.051670983,-0.022355806,0.032652456,-0.010283862,0.030560238,0.031871058,0.033011816,0.08585175,0.03527813,0.029173376,0.0014445416,0.018849833,0.03008323,-0.0042040786,0.07065717,-3.850007e-08,0.05272468,-0.05142279,0.02605266,-0.07801036,-0.018865528,0.03595191,-0.0005483482,-0.042140838,0.025325356,-0.02289765,-0.07674986,0.030130466,-0.031774946,0.020024523,-0.01511197,0.104486465,-0.027143542,0.0788495,0.0046885815,-0.07109321,-0.043729443,0.034255967,-0.061651733,0.010262732,-0.011214634,-0.022777677,0.06716903,0.02396398,0.008756534,-0.009122608,0.07374067,-0.03689757,-0.026017725,-0.005948005,0.008132693,0.0023241027,-0.02758106,-0.030121835,-0.009155181,0.003495776,-0.019210862,0.02410763,-0.047527336,-0.009774244,0.034898374,0.043093067,0.049618836,0.058001008,0.03941866,-0.0037909683,-0.0075178333,-0.0048118965,-0.004589039,-0.052974325,-0.048739787,-0.022637226,-0.06934668,-0.08657503,0.07357882,-0.07618742,-0.040019266,0.0827229,0.18711364,-0.01479713 +6.2.1.78,"The enzyme, characterized from the fungus Penicillium chrysogenum, acts on (3R)-beta-phenylalanine and has slight activity on some other amino acids including (3S)-beta-phenylalanine. It also acts on medium-chain-length alkanoic acids as EC 6.2.1.2 (medium-chain acyl-CoA ligase). In taxol-producing trees the enzyme is involved in taxol biosynthesis.",384,1.0,0.009207014,-0.06851917,-0.117606394,-0.04858979,0.0576941,0.030409837,-0.048677415,-0.026769197,0.0885723,-0.0051187733,0.11755283,-0.035550103,-0.06586359,0.035858925,-0.02636596,-0.0148841925,-0.12038369,0.03342443,-0.017732328,-0.055121824,0.11946585,0.058157153,-0.024212409,0.034365136,0.016341595,-0.117509,0.015024152,-0.026484972,-0.030865524,-0.100752175,-0.015000833,-0.04687121,-0.02506917,-0.004964659,0.053866338,0.05233298,-0.036692083,-0.057436034,0.057253845,0.0472813,0.02657179,-0.076841846,-0.030755358,-0.08682558,-0.0857248,-0.013177976,-0.012632434,0.03157241,0.058026895,0.0039892658,-0.05397161,-0.069607906,0.027246749,0.008730811,0.028824668,0.0074265604,-0.0071392697,0.033268858,0.0052875034,-0.009361843,-0.008112497,0.02171736,-0.0022233815,0.020094002,-0.06909302,0.0074979686,-0.0068968055,-0.08581627,-0.0031103874,-0.096806705,-0.091677144,-0.07487655,-0.0016411823,-0.018081572,0.011367119,0.014218813,-0.032931637,-0.0015872162,0.015996374,-0.06307027,-0.014301608,0.036657505,-0.049114686,0.06598622,0.018612148,-0.02591328,0.016148781,-0.0043346533,0.094231494,0.06583762,0.05675172,0.03016373,-0.044734914,0.009899381,-0.09326014,0.07346661,0.08261126,-0.017146325,0.003498029,-0.029674947,0.0038530186,0.06272028,-0.03604702,-0.106430486,-0.08583318,0.046866152,-0.101263896,0.07337752,-0.0062660403,-0.0046329307,0.043747686,0.009805269,-0.014606596,-0.015256379,-0.015750626,0.03775351,0.030989826,-0.10907764,-0.02287611,-0.012870852,-0.013414975,-0.0086107105,0.010089604,0.033756625,0.013105365,0.037806295,-0.010274008,7.32181e-34,0.07459339,0.06905678,-0.019208137,-0.047717866,0.054998245,-0.032638542,-0.041902106,0.056666777,-0.052130308,-0.08442949,-0.08044775,-0.041236624,-0.036015566,-0.00783544,0.057519797,0.02967906,-0.009780249,-0.0084581915,0.05534459,0.10691777,0.034500424,0.057851665,-0.035774704,0.005224836,0.02378193,0.039961744,-0.025047163,0.004436251,0.01997518,0.005505005,0.035633005,-0.07158179,-0.0337795,0.012500901,0.05981545,0.04205834,-0.01999466,-0.026599824,-0.03126413,0.056565132,0.056917626,0.039393485,0.06072631,-0.0035153667,0.004415124,0.001344208,0.0041310624,0.09069836,0.004688962,0.012505533,0.054313518,0.019050075,0.14607435,-0.008396226,0.021756416,0.01964708,-0.038273867,0.0069683003,0.032789197,0.051196404,0.02561194,0.008565032,-0.01793327,0.040932816,-0.03896664,0.020101937,-0.09087161,-0.024231918,0.034211576,-0.013077306,-0.084956825,-0.012962703,0.0007207562,0.023020012,0.018939959,-0.034335814,-0.0727889,-0.075688526,0.010130253,0.05900184,-0.019868424,-0.017439453,-0.0032497135,-0.050075363,-0.041854266,-0.071866736,-0.025252355,0.027401064,-0.01646273,-0.055655837,0.04663563,-0.023743443,0.0003559798,0.09100215,0.07454477,-2.828218e-33,0.12028373,-0.13775964,0.090481,-0.042089578,-0.03082237,0.03631858,-0.032447305,-0.012188323,-0.033249673,-0.0076694437,0.043721937,0.038089767,0.0052820714,0.0031391683,-0.004171249,0.023391359,0.03065017,0.13446848,0.0064634806,-0.011973062,-0.023476893,0.09489266,-0.012081415,0.04490851,0.045532856,0.005584816,-0.044574782,0.06958382,-0.010132148,0.053934697,0.041527335,0.035320643,0.02659534,-0.0055241124,-0.05759156,0.064292856,-0.018095456,-0.069310516,0.11884085,0.11875576,-0.011367054,-0.01859147,-0.010328375,-0.0072768526,0.039890274,0.027200742,-0.050882358,0.027599534,-0.030917205,-0.08757919,0.03751228,0.059861403,0.041468255,0.0103976885,0.046720415,0.06038314,-0.041683737,0.035725813,0.037850052,-0.06570999,-0.060612954,-0.06893108,-0.0064719175,0.018809406,0.0020580215,0.017539555,-0.03310899,-0.012746787,0.097333916,-0.024478592,0.042391174,0.04036999,-0.0070575774,0.084116936,-0.018279042,-0.024799522,-0.020615121,-0.0071860305,-0.016880102,-0.00455218,-0.029704984,-0.025228716,0.05470062,-0.08424076,-0.04952572,-0.090050496,0.06566318,0.04311295,-0.075925425,0.012539907,0.004099144,0.0061426503,0.016436534,0.08861792,0.107231595,-4.0797683e-08,-0.008290222,-0.024062056,0.011630152,-0.0837546,0.007635811,-0.011987839,0.05584043,0.013505274,0.0037098667,-0.045234237,-0.02974351,0.058356103,0.014300422,0.068572395,0.06802631,0.03262713,0.0039296662,0.0034789569,-0.03848756,0.047414366,-0.035683542,-0.031628225,-0.10989563,0.047661483,-0.035073046,-0.087836064,0.068454936,0.048783764,-0.042285286,0.015951432,-0.027247783,0.019236863,-0.047508597,-0.052984525,-0.07756515,0.07484036,-0.043017242,-0.055797573,-0.027808039,0.07358653,0.04592309,-0.11848068,-0.0965413,-0.038429897,0.0033962561,-0.016453585,-0.035953455,0.0192699,-0.0456598,-0.03642516,0.075351894,-0.009497966,-0.0010249228,-0.050724182,-0.076651156,-0.02325282,0.006156631,-0.06848489,-0.033560783,-0.07016589,0.049484167,0.0064299693,0.20051095,-0.0118787335 +6.4.1.10,"Requires Mg2+.The enzyme, found in some fungi such as members of the Boletales and Eurotiales order, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates 3-(4-hydroxyphenyl)pyruvate by adenylation and catalyses the dimerization/cyclization of two such molecules to form atromentin. Atromentin is a precursor for assorted metabolites produced by the fungi, including pulvinic acids and 2,5-diarylcyclopentenones.",384,1.0,-0.10473113,-0.11686156,-0.13488273,0.014182876,0.0681263,-0.009305723,-0.07538073,0.041215513,0.019326795,-7.966085e-05,0.044996742,-0.012935464,-0.017701633,-0.027528826,-0.057429194,0.02215152,0.0025537144,0.027449302,0.06682262,-0.08222951,0.09891692,0.040979553,0.04713988,0.03209518,0.05689189,-0.033686724,0.019217055,-0.041065156,-0.018334774,-0.013227705,-0.04850693,0.032587867,0.046939142,-0.078938805,0.044996083,0.15177228,-0.045328625,0.024369426,0.007407051,-0.07865098,0.03467391,-0.07340102,0.048636593,-0.0114164315,-0.02746753,-0.04333364,0.07137426,0.031452455,0.010052465,0.0015788595,-0.054470226,0.0020656795,-0.045589518,-0.05652794,-0.075570956,0.030459959,-0.108840555,-0.053265028,-0.03800511,0.010156719,-0.0111298775,-0.019167578,-0.030908566,0.00036310378,-0.03537942,-0.004094517,0.053641494,-0.057078816,-0.008107417,-0.016645053,0.021380525,-0.0768089,-0.028449776,0.042657476,0.025448244,0.059505925,0.017931236,-0.031497914,-0.0063183024,-0.023505371,0.019867513,0.021773238,0.076212116,0.061639763,0.0059840404,-0.043943737,0.05374203,0.04936031,-0.0013272177,0.08693792,0.08596009,0.07931721,0.017840743,0.022811482,-0.014195005,0.06815076,0.050211277,0.009060044,0.058842886,0.0024124715,-0.006600087,0.0589659,0.0060632937,0.0051600407,0.0067753354,-0.010039512,-0.058394417,0.032795332,0.08418721,0.0011462603,0.07888294,0.0051339488,0.048706755,-0.030121256,0.05028094,0.035641897,0.0020606765,-0.11296538,0.028367354,0.0094964905,-0.009573513,0.038305882,-0.03349162,0.09114102,-0.02223024,0.009748062,-0.07363828,3.077874e-33,0.055277985,0.05908706,0.022880275,0.04493487,-0.06916506,0.065601945,-0.10609407,-0.003795129,-0.00030330857,0.06788103,-0.10205224,-0.07695298,-0.03724239,0.04024393,0.01871931,-0.05877454,0.0021799798,0.009609293,0.11339055,-0.0045699347,-0.084315255,0.09829617,-0.058179542,0.024406249,0.035495564,0.11500878,-0.005985328,-0.05319417,0.008445035,0.0011141705,0.05401153,-0.116584815,-0.073782906,0.021273011,0.012329298,0.009002899,-0.062706746,-0.024301875,-0.008683945,0.055208024,-0.04372836,-0.011250975,-0.030006697,-0.0058613135,0.047371585,-0.065106004,-0.019681955,0.051759154,-0.02293732,0.07582906,0.062309492,0.03449978,0.111665204,0.028714953,-0.08305705,0.062027305,-0.049962163,0.06079519,0.042804703,0.020029021,0.043872956,0.04310239,-0.012399925,0.071627885,-0.042810142,-0.0028206315,-0.05262077,-0.1466213,-0.010224996,0.047151215,-0.012672639,0.009069093,0.043774504,0.014265328,0.04807937,-0.0021859386,-0.065407716,0.004851668,0.014101755,0.010314636,-0.0578043,0.0035016444,-0.011603391,0.015248723,-0.06906246,0.015543783,-0.020495746,-0.016220655,0.011795931,-0.0047575072,0.003385174,-0.036101352,-0.0010882373,0.06286677,0.042112283,-3.247861e-33,0.09608997,-0.08346692,0.08116851,-0.061043307,-0.10420525,0.04097773,0.030975794,-0.041222468,-0.052577086,-0.0071852435,0.07632361,-0.02011042,-0.05282883,-0.097978756,0.023442525,-0.003783538,0.035204925,0.06250616,-0.052693237,-0.0017120715,-0.0043995148,0.08936294,0.036155727,0.07057641,0.02709853,0.038423017,0.027803985,-0.021053124,0.008804617,0.07932633,-0.021631943,0.057917252,-0.008901308,-0.052808646,-0.074236326,0.05302999,-0.037468508,0.00916157,-0.028923435,0.042759378,0.013033115,0.055177778,-0.008010053,0.05510736,0.01932496,0.062366605,-0.017671889,0.058807492,0.026287992,-0.09992513,0.010847921,-0.0075156954,0.037848037,-0.11076504,0.06585037,-0.019615525,0.016177045,-0.043463223,0.027534915,-0.067029506,-0.029285353,-0.03776204,0.07233067,0.0025091171,0.03861243,0.09756209,-0.017946085,0.037148483,0.022694895,0.03140409,0.024076195,0.013049267,-0.028187027,0.022062413,0.034012064,0.03753162,0.017181102,-0.048682213,0.020837858,-0.104320385,-0.00897016,-0.010580806,0.020538844,-0.03035634,-0.05213354,-0.12761572,0.058844507,0.07254882,0.042609967,0.033453155,-0.03456348,0.05466352,-0.046166953,0.01591395,0.038395785,-4.251191e-08,0.014041057,-0.049727876,0.052777566,-0.09205774,-0.009596995,0.0007856844,0.01641678,-0.023977844,0.054695945,-0.055711675,-0.076231025,0.04413262,-0.017419908,-0.020144459,0.037352704,0.02695072,-0.0014974702,0.012469578,-0.039564062,-0.05343917,-0.07970022,0.02200132,-0.12219695,0.015082594,0.01469557,-0.076714225,-0.009522854,0.025217108,0.08314233,0.05280626,0.022150468,0.032407258,0.0023857565,-0.009560074,-0.027424928,0.007939907,-0.048173413,-0.08144826,-0.061742283,-0.06934114,-0.08688364,-0.023203766,0.035162386,-0.039684784,-0.062634915,-0.037138704,0.024048422,0.06923037,0.004498341,0.001117161,-0.015288061,-0.010716941,-0.055474114,-0.04494294,-0.05346791,-0.024652997,0.07450103,-0.09133805,-0.01851732,-0.11356042,-0.0076879337,-0.01006608,0.10361881,-0.08112548 +6.4.1.11,"Requires Mg2+. The enzyme, found in mushrooms of the Basidiomycota and Ascomycota phyla, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates 3-phenyl-2-oxopropanoate by adenylation and catalyses the dimerization/cyclization of two such molecules to form polyporic acid. Polyporic acid is a precursor for assorted metabolites produced by the fungi, such as the corticins.",384,1.0,-0.002856157,-0.06440234,-0.12388462,0.020671925,0.05038443,-0.019799873,-0.047834683,0.025522346,0.048912957,-0.0399808,0.08932392,-0.04763509,0.020336803,-0.0034714171,-0.051790446,0.03121095,0.030634223,0.0454511,0.0376039,-0.07563808,0.09963479,0.019703755,0.0044583227,0.05124956,0.013259778,-0.044390965,0.06471965,-0.039702322,-0.099448144,-0.039744597,-0.06027003,0.04606883,0.022430604,-0.054143075,0.05894795,0.11818805,-0.06940434,-0.006433776,0.057688717,-0.008110037,0.023682484,-0.06469047,0.057810973,-0.020091604,-0.01563662,-0.01462783,-0.044908423,0.025518939,0.07982493,-0.012927155,-0.077455275,-0.01729309,0.0041358736,-0.006861475,-0.06101485,0.012245037,-0.05556793,-0.028470362,-0.029245341,0.021326162,-0.017323693,0.011998562,-0.03312848,-0.028393198,5.521554e-05,-0.0040940456,0.006780606,-0.1004876,-0.002331872,-0.031846046,-0.06605354,-0.018802833,-0.06792612,0.022586182,0.014426411,0.0368674,-0.043662682,-0.020424245,0.013376621,-0.016385825,0.13634709,0.09788724,-0.0009978737,0.017803932,0.01790448,-0.00903757,0.08394886,0.0626066,-0.0001073727,0.05823266,0.05631369,0.04650308,-0.0004975882,0.02892063,-0.08076143,0.04683927,0.04668905,0.02607813,0.0046984334,-0.02019423,-0.03201566,0.003213053,0.019853478,-0.05055351,-0.016078146,-0.03363769,-0.0073729423,0.071149096,0.10073694,0.025455227,0.014971536,-0.021625772,0.014778187,-0.06935422,0.042353522,0.10697468,0.042605925,-0.046349518,-0.022734547,-0.06931846,0.010335524,-0.001604829,-0.020328382,0.027829843,0.024309935,-0.02011778,-0.13050212,1.4523272e-33,0.09290583,0.057069436,0.017426608,0.048045315,-0.033436447,0.012925516,-0.026975628,-0.031295,-0.015472564,-0.046397112,-0.12437271,-0.05019228,-0.07858458,0.055625685,0.045304123,-0.05579809,0.010110468,-0.004620814,0.13112843,0.04838642,-0.047937334,0.07552577,-0.04933657,0.0027547746,0.025944915,0.07789178,-0.03249363,-0.07963604,0.01929677,-0.008049353,0.036292102,-0.025534742,-0.0779443,0.038305853,0.07096256,-0.025711806,-0.044008628,-0.059092954,0.010592964,0.042075988,-0.057293024,0.021059997,0.019650055,-0.03344683,0.032799568,-0.020122513,-0.03836696,0.07634864,0.01265495,0.07467023,0.07904256,0.06966383,0.07774823,0.040075663,-0.06386154,0.021291211,-0.05530265,-0.004075833,0.014862797,0.027781174,0.058614876,0.06985743,-0.049423248,0.06854781,-0.06932012,-0.00064404076,-0.09807749,-0.07584123,0.05844889,0.027741177,-0.022668425,-0.06600455,-0.0033202947,0.052448846,0.0026410203,-0.04707538,-0.042957716,-0.022237245,0.0018421309,0.024336014,0.018035088,-0.04643514,0.007240649,-0.007808332,-0.07386998,0.038123887,0.017218864,-0.00049589307,-0.021664718,-0.06311467,-0.0372294,0.0065047704,-0.00034808952,0.058767583,0.061613005,-3.0553418e-33,0.17009379,-0.11628349,0.075979024,-0.05733612,-0.09682632,0.052414827,-0.0056168083,-0.09227662,-0.009507555,-0.011891401,0.017665762,0.0044218693,-0.015601838,-0.105807856,0.033472292,-0.017995205,-0.007977939,0.09517484,-0.030696172,-0.006271928,-0.022841662,0.118073635,-0.017435184,-0.0052117165,0.051574767,-0.010267239,0.059692536,0.04179434,-0.003283503,0.05618434,-0.039052498,0.0699403,-0.026401397,-0.013446142,-0.045510083,0.026226718,-0.05863305,-0.059908792,0.005675364,0.048830535,-0.021810679,0.027639968,0.002153953,0.03738876,0.07657028,0.04675667,-0.011779699,0.048845034,0.07031298,-0.09062025,0.051051322,-0.02663789,-0.0027504347,-0.09813618,0.043205593,-0.00069997064,-0.0052684243,-0.031561773,0.03674182,-0.104441516,-0.051498704,-0.027081953,0.03673533,-0.017209612,-0.018356528,0.11083536,0.016463608,-0.00019560881,0.066506006,-0.008564497,0.07381643,0.039310887,-0.01317468,0.047451213,-0.007441035,-0.0045769275,-0.07526975,0.010230311,-0.0093594575,0.0057271607,0.006173512,-0.018442832,0.04228589,-0.033769038,-0.03454234,-0.087463245,0.048927244,0.027169514,-0.055772353,0.07271552,-0.020621406,0.024822537,0.00016322569,0.06477632,0.033354074,-4.283652e-08,0.04677659,0.009117388,0.043914646,-0.099116236,-0.029016389,0.015549607,0.07206467,-0.044242404,0.060359545,-0.05085096,-0.08226577,0.03772459,-0.006732146,0.078481905,0.04182957,0.020761603,0.022717582,0.0379826,-0.031126453,0.008590749,-0.09310346,-0.025773099,-0.11798572,0.031027988,0.006796822,-0.06457293,0.051731065,0.02574918,0.052060127,0.05231983,-0.009949686,-0.0036901026,0.032605328,-0.080061704,-0.025923533,0.004562215,-0.04440836,-0.08835841,-0.0292233,-0.041631773,-0.04740568,-0.05893532,7.885893e-05,-0.02759909,-0.029592933,-0.04050077,0.017109921,0.010265749,-0.031227097,0.04088074,0.05247515,0.0051861857,-0.035176236,-0.017118497,-0.033883594,0.019888742,0.04888701,-0.08879442,-0.037387278,-0.116235316,-0.029180767,0.04430615,0.16579379,-0.04339727 +6.4.1.12,"Requires Mg2+. The enzyme, characterized from the fungus Aspergillus nidulans, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates (indol-3-yl)pyruvate by adenylation and catalyses the dimerization/cyclization of two such molecules to form didemethylasterriquinone D. didemethylasterriquinone D is subsequently converted to terrequinone A, a cytotoxic compound that displays a broad range of bioactivities.",384,1.0,-0.07495564,-0.015997237,-0.050509356,-0.040515322,0.01569193,-0.07797498,-0.053706307,0.067105904,0.02178835,0.0093593355,0.009935907,-0.015316582,0.041920867,0.029329715,-0.03469768,0.014456371,-0.0025869368,0.067913786,0.018764118,-0.03844782,0.06825756,0.117228,0.052201714,0.021525608,0.052161902,-0.006064252,0.03387601,-0.013282656,-0.0626401,0.0003581452,-0.0561157,0.007749896,0.02743561,-0.0954801,0.02594804,0.11291149,-0.04966143,0.05148663,-0.0068318443,-0.047194406,0.029120734,-0.075930856,0.046622258,-0.0076889144,-0.020181704,-0.050411664,-0.021382738,0.043959703,0.08037116,0.04706565,-0.07330188,-0.034534045,-0.045451786,0.01129718,0.019028487,0.042313617,-0.0831474,-0.0063086157,-0.065769464,-0.016443145,0.009506722,0.009345033,-0.031642545,-0.001762706,0.017275807,0.016679967,-0.012192418,-0.083797544,-0.033516318,-0.028985636,-0.00741389,-0.11913484,-0.03350116,0.015837114,-0.02145744,0.04319275,0.018402627,-0.020610007,0.059980214,-0.038836464,0.0771785,0.03792004,0.05992118,0.06611614,0.015351741,0.02880662,0.07093372,0.014905182,0.06809772,0.06080563,0.06484197,0.059675843,-0.01979527,0.016932368,-0.01736705,0.050733354,0.00048494554,0.0529438,0.024488878,0.018162118,0.038918648,0.03554625,-0.0346568,-0.062275745,-0.06645922,-0.0049171685,-0.04066685,-0.0028674013,0.045117233,-0.017899673,0.08939047,0.021935029,-0.0032174103,-0.024376305,0.004172692,0.049030032,0.025468964,-0.04617429,-0.031251296,-0.043565087,-0.010818006,0.025451463,0.02858782,0.05618577,0.0054521137,0.009982024,-0.06772601,3.2292013e-33,0.012792714,0.052381802,0.01682261,0.054269146,-0.00711993,0.03557184,-0.06389385,0.036377225,-0.021966415,-0.014229311,-0.118002765,-0.09068169,-0.057440724,0.039372496,0.047819443,-0.033614833,0.005556395,-0.002694039,0.10232177,0.014238798,-0.020467287,0.10025295,-0.035880357,0.03652878,0.017935501,0.11323901,-0.050169528,-0.05052181,0.031495646,0.0077815508,0.011771341,-0.14114583,-0.061260574,0.0038018655,0.039565526,0.017658459,-0.056864887,-0.03264908,-0.025065085,0.038650792,-0.099015564,-0.012189023,-0.03424727,-0.014652257,-0.0042089294,-0.023936672,-0.005146949,0.049316138,-0.02085742,0.07043092,0.08894586,0.034763977,0.109253235,0.002342859,-0.11340177,0.053104337,-0.04463046,-0.0074574673,0.05046893,0.022860907,-0.010512556,0.032382756,0.015503607,0.039215207,-0.018748704,-0.035585914,-0.097608775,-0.09096564,0.007073704,0.067297615,0.016032094,-0.002725994,0.010911059,0.036526237,0.01476509,-0.03192822,-0.032214757,-0.009515997,0.023261392,-0.010021623,-0.027778005,0.003615884,0.01657506,-0.053680226,-0.068615146,0.032505482,-7.644947e-05,-0.045679715,-0.020215342,-0.0031684465,0.0137655595,-0.0075886063,-0.052782606,0.02521482,0.06788801,-4.2238697e-33,0.0963735,-0.082437664,0.05329915,-0.03240987,-0.09557257,0.01226935,-0.011812163,0.0059005087,0.010530858,-0.040778458,0.074303895,-0.025324082,-0.032474924,-0.095226966,0.0046167583,-0.05133528,0.0036608342,0.12088978,-0.0361299,0.0015891778,-0.021670653,0.0904587,-0.05524493,0.044002302,0.025574578,0.037502166,-0.006782725,0.018879838,0.06312625,0.07544547,0.014091673,0.087526806,-0.014961276,-0.010670359,-0.01576593,0.11598707,0.018619558,-0.0036456876,-0.011761546,0.05803012,0.028684223,0.053310722,0.0016137741,0.08401946,0.03065069,0.0406259,-0.037168637,0.12363684,0.035448384,-0.1213017,0.0788109,-0.021556996,0.024119847,-0.065016605,0.078517035,0.023893815,0.044108298,-0.05195524,0.026261203,-0.057251323,-0.039525688,-0.081107154,0.017800786,0.012701933,0.020845247,0.098714516,-0.030318335,0.007200883,0.01696926,0.053904142,0.0400465,0.025467172,-0.038961712,-0.006821367,-0.023360815,-0.021182029,-0.001177422,-0.035337154,0.032956153,-0.07326837,0.015513575,-0.061020687,0.058246944,-0.015832927,-0.04845568,-0.09765004,0.037156876,0.096494325,-0.03772856,0.03921935,-0.06259721,0.026215224,-0.07714551,0.063928455,0.041866694,-4.447124e-08,0.066373974,-0.037084054,0.0145648215,-0.11327531,-0.008083081,0.0065220934,0.035643116,-0.02014706,0.10684728,-0.015138587,-0.06412026,0.03671777,-0.053903945,-0.014669368,0.020651814,0.003023125,0.036207203,0.05502586,-0.05062693,-0.020044995,-0.058753494,0.00635813,-0.15681997,-0.047726475,0.0054643727,-0.098405756,0.043181192,0.058217473,0.038603585,0.018758593,-0.02447146,0.006864221,-0.042078443,-0.042183295,-0.0680453,-0.022639582,-0.06477989,-0.089883335,0.00493621,-0.07820318,-0.094005466,-0.026714753,0.020481544,0.004246056,-0.08440448,-0.0758632,0.030721687,0.003844342,-0.0056234933,0.037494976,0.013124174,0.025823286,0.005711193,-0.087520644,-0.09948297,0.020877307,0.059039105,-0.0330876,-0.090419054,-0.14305036,-0.014031725,-0.012152508,0.14427494,-0.05429757 diff --git a/src/llm/entry_with_comments_202507250622.csv b/src/llm/entry_with_comments_202507250622.csv new file mode 100644 index 0000000..7c282e9 --- /dev/null +++ b/src/llm/entry_with_comments_202507250622.csv @@ -0,0 +1,6753 @@ +"ec_num","comments" +"1.1.1.1","A zinc protein. Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols." +"1.1.1.2",A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19 (L-glucuronate reductase) and EC 1.1.1.55 [lactaldehyde reductase (NADPH)]. Re-specific with respect to NADPH. +"1.1.1.3","The yeast enzyme acts most rapidly with NAD+; the Neurospora enzyme with NADP+. The enzyme from Escherichia coli is a multi-functional protein, which also catalyses the reaction of EC 2.7.2.4 (aspartate kinase)." +"1.1.1.4",Also converts diacetyl into acetoin with NADH as reductant. +"1.1.1.5",NADP+ also acts as acceptor. +"1.1.1.6","Also acts on propane-1,2-diol." +"1.1.1.8","Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity)." +"1.1.1.9",Also acts as an L-erythrulose reductase. +"1.1.1.14","This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+." +"1.1.1.15",Also converts xylitol into L-xylulose and L-glucitol into L-fructose. +"1.1.1.16",Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways. +"1.1.1.19",Also reduces D-galacturonate. May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)]. +"1.1.1.21",Has wide specificity. +"1.1.1.22",Also acts on UDP-alpha-D-2-deoxyglucose. +"1.1.1.23",Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase). +"1.1.1.24","The enzyme, found mostly in bacteria (mostly, but not exclusively in Gram-positive bacteria), fungi, and plants, participates in the degradation of quinate and shikimate with a strong preference for NAD+ as a cofactor. While the enzyme can act on both quinate and shikimate, activity is higher with the former. cf. EC 1.1.5.8, quinate/shikimate dehydrogenase (quinone), EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+], and EC 1.1.1.25, shikimate dehydrogenase (NADP+)." +"1.1.1.25","NAD+ cannot replace NADP+ [3]. In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10, 3-dehydroquinate dehydratase [4]. cf. EC 1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC 1.1.5.8, quinate/shikimate dehydrogenase (quinone), and EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+]." +"1.1.1.26",Reduces glyoxylate to glycolate or hydroxypyruvate to D-glycerate. +"1.1.1.27","Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also acts, more slowly, with the animal, but not the bacterial, enzyme." +"1.1.1.30",Also oxidizes other 3-hydroxymonocarboxylic acids. +"1.1.1.33",May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)]. +"1.1.1.34",The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}. +"1.1.1.35","Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3-hydroxyacyl-hydrolipoate. Some enzymes act, more slowly, with NADP+. Broad specificity to acyl chain-length (cf. EC 1.1.1.211 [long-chain-3-hydroxyacyl-CoA dehydrogenase])." +"1.1.1.37","There are several forms of malate dehydrogenases that differ by their use of substrate and cofactors. This NAD+-dependent enzyme forms oxaloacetate and unlike EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), is unable to convert it to pyruvate. Also oxidizes some other 2-hydroxydicarboxylic acids. cf. EC 1.1.1.82, malate dehydrogenase (NADP+); EC 1.1.1.299, malate dehydrogenase [NAD(P)+]; and EC 1.1.5.4, malate dehydrogenase (quinone)." +"1.1.1.38","Unlike EC 1.1.1.39, malate dehydrogenase (decarboxylating), this enzyme can also decarboxylate oxaloacetate. cf. EC 1.1.1.40, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)." +"1.1.1.39","There are several forms of malate dehydrogenases that differ in their use of substrates and cofactors. This particular form is found only in the plant kingdom. Unlike EC 1.1.1.38, which catalyses a similar reaction, this enzyme can not bind oxaloacetate, and thus does not decarboxylate exogeneously-added oxaloacetate. cf. EC 1.1.1.37, malate dehydrogenase; EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating); and EC 1.1.1.83, D-malate dehydrogenase (decarboxylating)." +"1.1.1.40","The enzyme catalyses the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and the decarboxylation of oxaloacetate. cf. EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), and EC 1.1.1.39, malate dehydrogenase (decarboxylating)." +"1.1.1.41","Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [7]. The enzyme from some species can also use NADP+ but much more slowly [9]." +"1.1.1.42","Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+), oxalosuccinate can be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [6]. The enzyme from some species can also use NAD+ but much more slowly [6,7]." +"1.1.1.44","The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)." +"1.1.1.45",Also oxidizes other L-3-hydroxyacids. +"1.1.1.47","This enzyme has similar activity with either NAD+ or NADP+. cf. EC 1.1.1.118, glucose 1-dehydrogenase (NAD+) and EC 1.1.1.119, glucose 1-dehydrogenase (NADP+)." +"1.1.1.48","This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose." +"1.1.1.49","The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+)." +"1.1.1.50","The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)." +"1.1.1.51",Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase. +"1.1.1.52","Also acts on other 3alpha-hydroxysteroids with an acidic side-chain. cf. EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+)." +"1.1.1.53",The 3alpha-hydroxy group or 20beta-hydroxy group of pregnane and androstane steroids can act as donor. +"1.1.1.54",Also acts on saturated primary alcohols. +"1.1.1.55",May be identical with EC 1.1.1.2 alcohol dehydrogenase (NADP+). +"1.1.1.57",Also reduces D-tagaturonate. +"1.1.1.62","The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase [3]. The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20alpha-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+." +"1.1.1.64",Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital. +"1.1.1.65",Also oxidizes pyridoxine phosphate. +"1.1.1.66","Also acts, more slowly, on 9-hydroxynonanoate and 11-hydroxyundecanoate." +"1.1.1.71","Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol." +"1.1.1.73","Acts, less rapidly, on other long-chain alcohols." +"1.1.1.75",Requires K+. +"1.1.1.76","This enzyme catalyses the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol. It can also catalyse the irreversible reduction of diacetyl to (S)-acetoin." +"1.1.1.78","This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH), by its cosubstrate requirement, reaction direction, and enantiomeric preference." +"1.1.1.79",Also reduces hydroxypyruvate to glycerate; has some affinity for NAD+. +"1.1.1.80","Also acts on other short-chain secondary alcohols and, slowly, on primary alcohols." +"1.1.1.82",Activated by light. +"1.1.1.84",Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate. +"1.1.1.85",The product decarboxylates spontaneously to yield 4-methyl-2-oxopentanoate. +"1.1.1.86","Also catalyses the reduction of 2-ethyl-2-hydroxy-3-oxobutanoate to 2,3-dihydroxy-3-methylpentanoate. The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382, ketol-acid reductoisomerase (NAD+) and EC 1.1.1.383, ketol-acid reductoisomerase [NAD(P)+])." +"1.1.1.87",Forms part of the lysine biosynthesis pathway in fungi [3]. +"1.1.1.90","A group of enzymes with broad specificity towards primary alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity towards short-chain aliphatic alcohols." +"1.1.1.91","Also acts on some aliphatic aldehydes, but cinnamaldehyde was the best substrate found." +"1.1.1.92",Also reduces hydroxypyruvate to D-glycerate and glyoxylate to glycolate. +"1.1.1.93","meso-tartrate and (R,R)-tartrate act as substrates. Requires Mn2+ and a monovalent cation." +"1.1.1.94",The enzyme from Escherichia coli shows specificity for the B side of NADPH. +"1.1.1.95","This enzyme catalyses the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis. The reaction occurs predominantly in the direction of reduction. The enzyme from the bacterium Escherichia coli also catalyses the activity of EC 1.1.1.399, 2-oxoglutarate reductase [6]." +"1.3.98.4","The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyses the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline." +"1.1.1.96",Substrates contain an aromatic ring with a pyruvate side chain. The most active substrates are halogenated derivatives. Compounds with hydroxy or amino groups in the 3 or 5 position are inactive. +"1.1.1.100",Exhibits a marked preference for acyl-carrier-protein derivatives over CoA derivatives as substrates. +"1.1.1.101",Also acts on alkylglycerone 3-phosphate and alkylglycerol 3-phosphate. +"1.1.1.103","This enzyme acts in concert with EC 2.3.1.29, glycine C-acetyltransferase, in the degradation of threonine to glycine. This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex [2]. In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone." +"1.1.1.104","The enzyme, isolated from animals, is specific for 4-oxo-L-proline and cis-4-hydroxy-L-proline. It has no activity with trans-4-hydroxy-L-proline." +"1.1.1.105","The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form [2]. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis-retinol dehydrogenase). Also active with 3alpha-hydroxysteroids [2]." +"1.1.1.107",The enzyme acts on the hemiacetal form of the substrate. +"1.1.1.110","The enzymes from anaerobic bacteria such as Clostridium sporogenes participate in the fermentation pathways of L-phenylalanine, L-tyrosine and L-tryptophan. The enzyme from the yeast Candida maltosa has similar activity, but, unlike the bacterial enzyme, requires Mn2+ and can also use NADPH with lower activity." +"1.1.1.112","3(20)alpha-Hydroxysteroids are also oxidized, more slowly." +"1.1.1.113",Also oxidizes D-arabinose and D-lyxose. +"1.1.1.115","Also acts, more slowly, on D-xylose and other pentoses." +"1.1.1.117","Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose." +"1.1.1.119","Also oxidizes D-mannose, 2-deoxy-D-glucose and 2-amino-2-deoxy-D-mannose." +"1.1.1.120","Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose." +"1.1.1.121","Acts on D-glucose, 2-deoxy- and 6-deoxy-D-glucose, D-galactose, 6-deoxy-D-galactose, 2-deoxy-L-arabinose and D-xylose." +"1.1.1.122","Acts on L-fucose, D-arabinose and L-xylose; the animal enzyme was also shown to act on L-arabinose, and the enzyme from Pseudomonas caryophylli on L-glucose." +"1.1.1.127","The enzyme from Pseudomonas acts equally well on NAD+ or NADP+, while that from Erwinia chrysanthemi and Escherichia coli is more specific for NAD+." +"1.1.1.132",Also acts on the corresponding deoxynucleoside diphosphate derivative as a substrate. +"1.1.1.133","In the reverse direction, reduction on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyses epimerization at C-3 and C-5; the complex has been referred to as dTDP-L-rhamnose synthase." +"1.1.1.134",Oxidation on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyses epimerization at C-3 and C-5. +"1.1.1.136","This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide." +"1.1.1.137","The enzyme, characterized from the bacterium Lactobacillus plantarum, can use both NAD+ and NADP+ as electron acceptor [cf. EC 1.1.1.405, ribitol-5-phosphate 2-dehydrogenase (NADP+)]." +"1.1.1.141","Acts on prostaglandin E2, F2alpha and B1, but not on prostaglandin D2. cf. EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)." +"1.1.1.144","Oxidizes a number of primary alcohols with the alcohol group allylic to an endocyclic double bond and a 6-membered ring, either aromatic or hydroaromatic." +"1.1.1.145","This activity is found in several bifunctional enzymes that catalyse the oxidative conversion of Delta5-3-hydroxy steroids to a Delta4-3-oxo configuration. This conversion is carried out in two separate, sequential reactions; in the first reaction, which requires NAD+, the enzyme catalyses the dehydrogenation of the 3beta-hydroxy steroid to a 3-oxo intermediate. In the second reaction the reduced cosubstrate, which remains attached to the enzyme, activates the isomerization of the Delta5 form to a Delta4 form (cf. EC 5.3.3.1, steroid Delta-isomerase). Substrates include dehydroepiandrosterone (which is converted into androst-5-ene-3,17-dione), pregnenolone (converted to progesterone) and cholest-5-en-3-one, an intermediate of cholesterol degradation." +"1.1.1.149",Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase). +"1.1.1.150",Acts on a number of 21-hydroxycorticosteroids. +"1.1.1.151",Acts on a number of 21-hydroxycorticosteroids. +"1.1.1.153","This enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. cf. EC 1.1.1.325, sepiapterin reductase (L-threo-7,8-dihydrobiopterin-forming)." +"1.1.1.154","Involved in catabolism of purines. The enzyme from the bacterium Arthrobacter allantoicus can use both NAD+ and NADP+ with similar activity. cf. EC 1.1.1.350, ureidoglycolate dehydrogenase (NAD+)." +"1.1.1.158","A flavoprotein (FAD). Sodium dithionite, sodium borohydride and, to a lesser extent, NADH, can replace NADPH." +"1.1.1.159",Catalyses the oxidation of the 7alpha-hydroxy group of bile acids and alcohols both in their free and conjugated forms. The Bacteroides fragilis and Clostridium enzymes can also utilize NADP+. +"1.1.1.160","Also acts, more slowly, with NAD+." +"1.1.1.162","NAD+ is also utilized, but more slowly." +"1.1.1.163","4-Methylcyclohexanol and cyclohexanol can also act as substrates." +"1.1.1.164",The liver enzyme acts on long-chain alcohols from C8 to C16. The Euglena enzyme also oxidizes the corresponding aldehydes to fatty acids. +"1.1.1.165","Acts on a variety of 2-alkyn-1-ols, and also on 1,4-butanediol. NADP+ also acts as acceptor, but more slowly." +"1.1.1.166","Acts on hydroxycyclohexanecarboxylates that have an equatorial carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial hydroxy or carbonyl group at C-4, including (-)-quinate and (-)-shikimate." +"1.1.1.168","The yeast enzyme differs from that from Escherichia coli [EC 1.1.1.214 2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase." +"1.1.1.170","The enzyme participates in the biosynthesis of several important sterols such as ergosterol and cholesterol. It is part of a three enzyme system that removes methyl groups from the C-4 position of steroid molecules. The first enzyme, EC 1.14.18.9, 4alpha-methylsterol monooxygenase, catalyses three successive oxidations of the methyl group, resulting in a carboxyl group; the second enzyme, EC 1.1.1.170, catalyses an oxidative decarboxylation that results in a reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group; and the last enzyme, EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, reduces the 3-oxo group back to a 3beta-hydroxyl. If a second methyl group remains at the C-4 position, this enzyme also catalyses its epimerization from 4beta to 4alpha orientation, so it could serve as a substrate for a second round of demethylation. cf. EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)." +"1.1.1.174","Also oxidizes, more slowly, the cis isomer and 2-hydroxycyclohexanone." +"1.1.1.176","Catalyses the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated form. Also acts on bile alcohols." +"1.1.1.178","Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA." +"1.1.1.179","The enzyme, characterized from pig arterial vessels and eye lens, also acts, more slowly, on L-arabinose and D-ribose. cf. EC 1.1.1.424, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)." +"1.1.1.181","Highly specific for 3beta,7alpha-dihydroxy-C27-steroids with Delta5-double bond." +"1.1.1.183","Also acts, more slowly on farnesol but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial." +"1.1.1.184","Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. Si-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)]." +"1.1.1.185","The 2-hydroxycarbonyl compound formed can be further oxidized to a vicinal dicarbonyl compound. In the reverse direction, vicinal diketones, glyceraldehyde, glyoxal, methylglyoxal, 2-oxo-hydroxyketones and 2-ketoacid esters can be reduced." +"1.1.1.187","The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-alpha-D-rhamnose and its C-4 epimer, GDP-6-deoxy-alpha-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase." +"1.1.1.188","Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone." +"1.1.1.189",Reduces prostaglandin E2 to prostaglandin F2alpha. A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds. May be identical with EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+). +"1.1.1.192",Hexadecanol is a good substrate. +"1.1.1.194","Specific for coniferyl alcohol; does not act on cinnamyl alcohol, 4-coumaryl alcohol or sinapyl alcohol." +"1.1.1.195","Acts on coniferyl alcohol, sinapyl alcohol, 4-coumaryl alcohol and cinnamyl alcohol (cf. EC 1.1.1.194 coniferyl-alcohol dehydrogenase)." +"1.1.1.196",Specific for prostaglandins D [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)]. +"1.1.1.197","Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase." +"1.1.1.198","NADP+ can also act, but more slowly." +"1.1.1.200","In the reverse reaction, acts also on D-galactose 6-phosphate and, more slowly, on D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate." +"1.1.1.201",Catalyses the oxidation of the 7beta-hydroxy group of bile acids such as ursodeoxycholate. +"1.1.1.203","Requires Mg2+. The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate. The enzyme can only accept the beta anomeric form of the substrate [4]. The 1,5-lactone product is rather stable at cytosolic pH and does not hydrolyse spontaneously at a substantial rate." +"1.1.1.205",The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. +"1.1.1.206","Also oxidizes other tropan-3alpha-ols, but not the corresponding beta-derivatives [1]. This enzyme along with EC 1.1.1.236, tropinone reductase II, represents a branch point in tropane alkaloid metabolism [4]. Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [4]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [3]." +"1.1.1.207",Not identical with EC 1.1.1.208 (+)-neomenthol dehydrogenase. Acts also on a number of other cyclohexanols and cyclohexenols. +"1.1.1.208",Not identical with EC 1.1.1.207 (-)-menthol dehydrogenase. Acts also on a number of other cyclohexanols and cyclohexenols. +"1.1.1.209","Acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase)." +"1.1.1.210",Also acts on 20alpha-hydroxysteroids. +"1.1.1.211","This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase)." +"1.1.1.212","Forms part of the fatty acid synthase system in plants. Can be separated from EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase." +"1.1.1.213","The enzyme acts on multiple 3alpha-hydroxysteroids. Re-specific with respect to NAD+ or NADP+ [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)]. Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by EC 1.1.1.357, 3alpha-hydroxysteroid 3-dehydrogenase." +"1.1.1.214","The Escherichia coli enzyme differs from that from yeast [EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific)], which is specific for the Re-face of NADP+, and in receptor requirements from EC 1.1.99.26 3-hydroxycyclohexanone dehydrogenase." +"1.1.1.215","Also acts on L-idonate, D-galactonate and D-xylonate." +"1.1.1.216","Also acts, more slowly, on (2Z,6E)-farnesol, geraniol, citronerol and nerol." +"1.1.1.217","Also acts on benzyl (2S,3S)-2-methyl-3-hydroxybutanoate; otherwise highly specific." +"1.1.1.218","Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analogue. Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol)." +"1.1.1.219","This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly." +"1.1.1.220",Not identical with EC 1.1.1.153 sepiapterin reductase. +"1.1.1.221",Oxidizes vomifoliol to dehydrovomifoliol; involved in the metabolism of abscisic acid in Corynebacterium sp. +"1.1.1.222","Also acts, more slowly, on (R)-3-phenyllactate, (R)-3-(indol-3-yl)lactate and (R)-lactate." +"1.1.1.223","Acts on (-)-trans-isopiperitenol, (+)-trans-piperitenol and (+)-trans-pulegol. Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves." +"1.1.1.224",Involved in the biosynthesis of mannitol in celery (Apium graveolens) leaves. +"1.1.1.225",Chlordecone is an organochlorine pesticide. +"1.1.1.226","The enzyme from Corynebacterium cyclohexanicum is highly specific for the trans-4-hydroxy derivative. cf. EC 1.1.1.438, cis-4-hydroxycyclohexanecarboxylate dehydrogenase." +"1.1.1.227","NADP+ can also act, but more slowly." +"1.1.1.228","NADP+ can also act, but more slowly. Involved in the biosynthesis of (+)-3-thujone and (-)-3-isothujone." +"1.1.1.229","Also acts on diethyl (2S,3R)-2-methyl-3-hydroxysuccinate; and on the corresponding dimethyl esters." +"1.1.1.230",Highly specific to 3alpha-hydroxy derivatives of glycyrrhetinate and its analogues. Not identical to EC 1.1.1.50 3alpha-hydroxysteroid dehydrogenase (Si-specific). +"1.1.1.231",Specific for prostaglandin I2. +"1.1.1.233",Acts on acetyl-D-mannosamine and glycolyl-D-mannosamine. Highly specific. +"1.1.1.234",Involved in the biosynthesis of 3-deoxyanthocyanidins from flavanones such as naringenin or eriodictyol. +"1.1.1.235",Si-specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin. +"1.1.1.236","This enzyme along with EC 1.1.1.206, tropine dehydrogenase, represents a branch point in tropane alkaloid metabolism [3]. Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [3]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [2]." +"1.1.1.237","The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH." +"1.1.1.238","Acts on a number of bile acids, both in their free and conjugated forms." +"1.1.1.239",Also acts on other 17beta-hydroxysteroids and on the 3alpha-hydroxy group of pregnanes and bile acids. Different from EC 1.1.1.50 3alpha-hydroxysteroid dehydrogenase (Si-specific) or EC 1.1.1.213 3alpha-hydroxysteroid dehydrogenase (Re-specific). +"1.1.1.240","Also acts on N-acetylgalactosamine and, more slowly, on N-acetylmannosamine. Anomeric specificity was tested with N-acetyl-D-glucosamine, and it was shown that the enzyme is specific for the alpha anomer." +"1.1.1.245",Also oxidizes some other alicyclic alcohols and diols. +"1.1.1.246",The reaction is catalysed in the opposite direction to that shown. This plant enzyme catalyses the penultimate step in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. +"1.1.1.247","Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum." +"1.1.1.248","Catalyses the reversible reduction of salutaridine to salutaridinol, which is a direct precursor of morphinan alkaloids in the poppy plant." +"1.1.1.251",The enzyme from the bacterium Escherichia coli is involved in a galactitol degradation pathway. It contains two zinc atoms per subunit. +"1.1.1.252","Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC 4.2.1.94 scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi." +"1.1.1.254","Specific for the (S)-enantiomer of carnitine, i.e., the enantiomer of the substrate of EC 1.1.1.108 carnitine 3-dehydrogenase" +"1.1.1.255",The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation. The enzyme is specific for NAD+ and does not use NADP+. +"1.1.1.256",Involved in the pathway for fluorene metabolism in Arthrobacter sp. +"1.1.1.257",Involved in the toluene-4-sulfonate degradation pathway in Comamonas testosteroni. +"1.1.1.258",Involved in the cyclohexanol degradation pathway in Acinetobacter NCIB 9871. +"1.1.1.259",Involved in the anaerobic pathway of benzoate degradation in bacteria. +"1.1.1.260","Studies on the effects of growth-stage and nutrient supply on the stereochemistry of sulcatone reduction in Clostridia pasteurianum, C. tyrobutyricum and Lactobacillus brevis suggest that there may be at least two sulcatone reductases with different stereospecificities." +"1.1.1.261","This enzyme is found primarily as a Zn2+-dependent form in archaea but a Ni2+-dependent form has been found in Gram-positive bacteria [6]. The Zn2+-dependent metalloenzyme is responsible for the formation of archaea-specific sn-glycerol-1-phosphate, the first step in the biosynthesis of polar lipids in archaea. It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes. The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase) and EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase), which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [4]. Activity of the enzyme is stimulated by K+ [2]." +"1.1.1.262", The enzyme is part of the biosynthesis pathway of the cofactor pyridoxal 5'-phosphate found in anaerobic bacteria. +"1.1.1.263","Also reduces pyridine-3-aldehyde and 2,3-butanedione. Acetaldehyde, 2-dehydroglucose (glucosone) and glucuronate are poor substrates, but there is no detectable action on glucose, mannose and fructose." +"1.1.1.264","The enzyme from the bacterium Escherichia coli is specific for 5-dehydro-D-gluconate. cf. EC 1.1.1.366, L-idonate 5-dehydrogenase (NAD+)." +"1.1.1.265","The enzyme purified from Saccharomyces cerevisiae catalyses the reduction of a number of straight-chain and branched aldehydes, as well as some aromatic aldehydes." +"1.1.1.266","The enzymes from the Gram-negative bacteria Aggregatibacter actinomycetemcomitans and Escherichia coli O52 are involved in activation of fucose for incorporation into capsular polysaccharide O-antigens [1,3]. The enzyme from the Gram-positive bacterium Anoxybacillus tepidamans (Geobacillus tepidamans) is involved in activation of fucose for incorporation into the organism's S-layer [2]. The enzyme from Escherichia coli O52 has a higher catalytic efficiency with NADH than with NADPH [3]." +"1.1.1.267","The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA}). The mechanism has been shown to be a retroaldol/aldol reaction [2]." +"1.3.1.88",A flavoprotein. The enzyme specifically modifies uracil16 and uracil17 in tRNA. +"1.1.1.268","The enzyme is highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, 2-(S)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (S)-enantiomer. This enzyme forms component III of a four-component enzyme system (comprising EC 4.4.1.23 [2-hydroxypropyl-CoM lyase; component I], EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2." +"1.1.1.269","The enzyme is highly specific for (2S)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.268, 2-(R)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (R)-enantiomer. This enzyme forms component IV of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2." +"1.1.1.270","The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4]." +"1.1.1.271",Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. +"1.1.1.272","This enzyme, characterized from the halophilic archaeon Haloferax mediterranei and the mold Aspergillus oryzae, catalyses a stereospecific reduction of 2-oxocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. The enzyme prefers substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use NADH with much lower efficiency. cf. EC 1.1.1.345, (D)-2-hydroxyacid dehydrogenase (NAD+)." +"1.1.1.273",Also acts on related alkaloids with an endo-aldehyde group as vellosimine (same stereochemistry at C-16) but only slight activity with exo-aldehydes. Detected in many cell suspension cultures of plants from the family Apocynaceae. +"1.1.1.274","The enzyme is involved in the catabolism of 2,5-didehydrogluconate. cf. EC 1.1.1.346, 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)." +"1.1.1.343","Highly specific for NAD+. The enzyme catalyses both the oxidation and decarboxylation of 6-phospho-D-gluconate. In the bacterium Methylobacillus flagellatus the enzyme participates in a formaldehyde oxidation pathway [4]. cf. EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)." +"1.1.1.275",NADP+ cannot replace NAD+. Forms part of the monoterpenoid biosynthesis pathway in Carum carvi (caraway) seeds. +"1.1.1.276","NAD+ cannot replace NADP+ [cf. EC 1.1.1.387, serine 3-dehydrogenase (NAD+)]." +"1.1.1.279","Also acts on ethyl (R)-3-oxobutanoate and some other (R)-3-hydroxy acid esters. The (R)- symbol is allotted on the assumption that no substituents change the order of priority from O-3 > C-2 > C-4. A subunit of yeast fatty acid synthase EC 2.3.1.86, fatty-acyl-CoA synthase system. cf. EC 1.1.1.280, (S)-3-hydroxyacid ester dehydrogenase." +"1.1.1.280",Also acts on 4-oxo- and 5-oxo-fatty acids and their esters. cf. EC 1.1.1.279 (R)-3-hydroxyacid-ester dehydrogenase. +"1.1.1.281","This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria." +"1.1.1.282","This is the second shikimate dehydrogenase enzyme found in Escherichia coli. It can use both quinate and shikimate as substrates and either NAD+ or NADP+ as acceptor. The low catalytic efficiency with both quinate and shikimate suggests that neither may be the physiological substrate. cf. EC 1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC 1.1.5.8, quinate/shikimate dehydrogenase (quinone), and EC 1.1.1.25, shikimate dehydrogenase (NADP+)." +"1.1.1.283","The enzyme from the yeast Saccharomyces cerevisiae catalyses the reduction of a keto group in a number of compounds, forming enantiopure products. Among the substrates are methylglyoxal (which is reduced to (S)-lactaldehyde) [1,2], 3-methylbutanal [3], hexane-2,5-dione [4] and 3-chloro-1-phenylpropan-1-one [5]. The enzyme differs from EC 1.1.1.78, methylglyoxal reductase (NADH), which is found in mammals, by its cosubstrate requirement, reaction direction, and enantiomeric preference." +"1.1.1.284","The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase. This enzyme forms part of the pathway that detoxifies formaldehyde, since the product is hydrolysed by EC 3.1.2.12, S-formylglutathione hydrolase. The human enzyme belongs to the family of zinc-dependent alcohol dehydrogenases. Also specifically reduces S-nitrosylglutathione." +"1.1.1.286","Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways." +"1.1.1.287","The enzyme from the rust fungus Uromyces fabae can use D-arabinitol and D-mannitol as substrates in the forward direction and D-xylulose, D-ribulose and, to a lesser extent, D-fructose as substrates in the reverse direction. This enzyme carries out the reactions of both EC 1.1.1.11, D-arabinitol 4-dehydrogenase and EC 1.1.1.250, D-arabinitol 2-dehydrogenase, but unlike them, uses NADP+ rather than NAD+ as cofactor. D-Arabinitol is capable of quenching reactive oxygen species involved in defense reactions of the host plant." +"1.1.1.288","Requires a molybdenum cofactor for activity. NADP+ cannot replace NAD+ and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate [3]. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14 (abscisic-aldehyde oxidase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.14.137 [(+)-abscisic acid 8'-hydroxylase]. Abscisic acid is a sesquiterpenoid plant hormone that is involved in the control of a wide range of essential physiological processes, including seed development, germination and responses to stress [3]." +"1.1.2.2","The enzyme from the bacterium Gluconobacter oxydans acts on polyols with a D-lyxo configuration, such as D-mannitol and D-sorbitol, with preference towards the former." +"1.1.2.3",Identical with cytochrome b2; a flavohemoprotein (FMN). +"1.1.2.4",A flavoprotein (FAD). +"1.1.2.5",The enzyme from the sulfate-reducing bacterium Desulfovibrio vulgaris can also act on (R)-2-hydroxybutanoate. +"1.1.3.3",A flavoprotein (FAD). +"1.1.3.4",A flavoprotein (FAD). +"1.1.3.5","A copper glycoprotein. Also oxidizes D-galactose, D-mannose, maltose, lactose and cellobiose." +"1.1.3.6","Contains FAD. Cholesterol oxidases are secreted bacterial bifunctional enzymes that catalyse the first two steps in the degradation of cholesterol. The enzyme catalyses the oxidation of the 3beta-hydroxyl group to a keto group, and the isomerization of the double bond in the oxidized steroid ring system from the Delta5 position to Delta6 position (cf. EC 5.3.3.1, steroid Delta-isomerase)." +"1.1.3.7",Oxidizes many primary alcohols containing an aromatic ring; best substrates are (2-naphthyl)methanol and 3-methoxybenzyl alcohol. +"1.1.3.8","A microsomal flavoprotein (FAD). The product spontaneously isomerizes to L-ascorbate. While most higher animals can synthesize asborbic acid, primates and guinea pigs cannot [3]." +"1.1.3.9",A copper protein. +"1.1.3.10","A flavoprotein (FAD). Also oxidizes D-xylose, L-sorbose and D-glucono-1,5-lactone, which have the same ring conformation and configuration at C-2, C-3 and C-4." +"1.1.3.11","Also acts on D-glucose, D-galactose and D-xylose, but not on D-fructose. 2,6-Dichloroindophenol can act as acceptor." +"1.1.3.12","A flavoprotein. Can also use 2,6-dichloroindophenol as an acceptor." +"1.1.3.13","The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism [4]. The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols." +"1.1.3.15","A flavoprotein (FMN). Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids, and was previously listed as EC 1.1.3.1, glycolate oxidase; the B form preferentially oxidizes long-chain and aromatic hydroxy acids. The rat isoenzyme B also acts as EC 1.4.3.2, L-amino-acid oxidase." +"1.1.3.16","2,6-Dichloroindophenol can act as an acceptor." +"1.1.3.17","A flavoprotein (FAD). In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyse the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. In plants, the first reaction is catalysed by EC 1.14.15.7, choline monooxygenase, whereas in animals and many bacteria, it is catalysed by either membrane-bound choline dehydrogenase (EC 1.1.99.1) or soluble choline oxidase (EC 1.1.3.17) [6]. The enzyme involved in the second step, EC 1.2.1.8, betaine-aldehyde dehydrogenase, appears to be the same in those plants, animals and bacteria that use two separate enzymes." +"1.1.3.18","Acts on secondary alcohols with five or more carbons, and polyvinyl alcohols with molecular mass over 300 Da. The Pseudomonas enzyme contains one atom of non-heme iron per molecule." +"1.1.3.19","A flavoprotein (FAD), requires Mn2+. The enzyme from the bacterium Pseudomonas putida is involved in the degradation of mandelate. " +"1.1.3.20",Oxidizes long-chain fatty alcohols; best substrate is dodecyl alcohol. +"1.1.3.21",A flavoprotein (FAD). +"1.1.3.23",A flavoprotein (FAD). The product differs from thiamine in replacement of -CH2.CH2.OH by -CH2.COOH; the two-step oxidation proceeds without the release of the intermediate aldehyde from the enzyme. +"1.1.3.24","A flavoprotein. Acts on the 1,4-lactones of L-galactonic, D-altronic, L-fuconic, D-arabinic and D-threonic acids; not identical with EC 1.1.3.8 L-gulonolactone oxidase. (cf. EC 1.3.2.3 galactonolactone dehydrogenase)." +"1.1.3.28","Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.39, nucleoside oxidase (H2O2-forming), as it produces water rather than hydrogen peroxide." +"1.1.3.29","The enzyme, found in bacteria, also acts more slowly on N-acetyl-D-mannosamine." +"1.1.3.37","A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot [1]. With L-galactono-1,4-lactone as substrate, the product is L-ascorbate [3]. The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS no.: 5776-48-7; formula: C6H8O6), although it was referred to as a five-carbon compound [1]." +"1.1.3.38",Vanillyl-alcohol oxidase from Penicillium simplicissimum contains covalently bound FAD. It converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes. The allyl group of 4-allylphenols is also converted into the -CH=CH-CH2OH group. +"1.1.3.39","A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2'-deoxyribonucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water." +"1.1.3.40","Also catalyses the oxidation of D-arabinitol and, to a lesser extent, D-glucitol (sorbitol), whereas L-arabinitol is not a good substrate. The enzyme from the snails Helix aspersa and Arion ater is found in a specialised tubular organelle that has been termed the mannosome." +"1.1.3.41","The enzyme from Streptomyces sp. IKD472 and from Streptomyces coelicolor is a monomeric oxidase containing one molecule of FAD per molecule of protein [1,2]. While xylitol (five carbons) and sorbitol (6 carbons) are the preferred substrates, other alditols, including L-threitol (four carbons), D-arabinitol (five carbons), D-galactitol (six carbons) and D-mannitol (six carbons) can also act as substrates, but more slowly [1,2]. Belongs in the vanillyl-alcohol-oxidase family of enzymes [2]." +"1.1.4.1","In the reverse reaction, vitamin K 2,3-epoxide is reduced to vitamin K and possibly to vitamin K hydroquinone by 1,4-dithiothreitol, which is oxidized to a disulfide; some other dithiols and 4-butanethiol can also act. Inhibited strongly by warfarin [cf. EC 1.1.4.2 vitamin-K-epoxide reductase (warfarin-insensitive)]." +"1.1.4.2","In the reverse reaction, vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.1.4.1 vitamin-K-epoxide reductase (warfarin-sensitive)]." +"1.1.5.2",Integral membrane protein containing PQQ as a cofactor. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses. +"1.1.99.1","A quinoprotein. In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyse the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. In plants, the first reaction is catalysed by EC 1.14.15.7, choline monooxygenase, whereas in animals and many bacteria, it is catalysed by either membrane-bound choline dehydrogenase (EC 1.1.99.1) or soluble choline oxidase (EC 1.1.3.17) [4]. The enzyme involved in the second step, EC 1.2.1.8, betaine-aldehyde dehydrogenase, appears to be the same in plants, animals and bacteria." +"1.1.99.3",A flavoprotein (FAD). +"1.1.99.4",A flavoprotein. +"1.1.99.6","The zinc flavoprotein (FAD) from the archaeon Archaeoglobus fulgidus cannot utilize NAD+, cytochrome c, methylene blue or dimethylnaphthoquinone as acceptors. In vitro it is active with artificial electron acceptors such as 2,6-dichlorophenolindophenol, but the physiological acceptor is not yet known." +"1.1.99.7",Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This cofactor cannot be removed without denaturation of the protein. +"1.1.99.8","A quinoprotein. Acts on a wide range of primary alcohols, including methanol [cf. EC 1.1.99.20 alkan-1-ol dehydrogenase (acceptor)]." +"1.1.99.9",A flavoprotein (FAD). +"1.1.99.10","A glycoprotein containing one mole of FAD per mole of enzyme. 2,6-Dichloroindophenol can act as acceptor" +"1.1.99.11","2,6-Dichloroindophenol can act as acceptor." +"1.1.99.12","2,6-Dichloroindophenol can act as acceptor." +"1.1.99.13","The enzymes from members of the Rhizobiaceae family (such as Agrobacterium tumefaciens) act on disaccharides that contain a glucose moiety at the non-reducing end, such as sucrose, trehalose, leucrose, palatinose, trehalulose, and maltitol, forming the respective 3'-keto derivatives. cf. EC 1.1.2.11, glucoside 3-dehydrogenase (cytochrome c)." +"1.1.99.14","Also acts on (R)-lactate. 2,6-Dichloroindophenol and phenazine methosulfate can act as acceptors." +"1.1.99.16",A flavoprotein (FAD). +"1.1.99.18","Also acts, more slowly, on cello-oligosaccharides, lactose and D-glucosyl-1,4-beta-D-mannose. The enzyme from the white rot fungus Phanerochaete chrysosporium is unusual in having two redoxin domains, one containing a flavin and the other a protoheme group. It transfers reducing equivalents from cellobiose to two types of redox acceptor: two-electron oxidants, including redox dyes, benzoquinones, and molecular oxygen, and one-electron oxidants, including semiquinone species, iron(II) complexes, and the model acceptor cytochrome c [9]. 2,6-Dichloroindophenol can act as acceptor in vitro." +"1.1.99.19",Also oxidizes thymine. The enzyme acts on the hydrated derivative of the substrate. Formerly EC 1.2.99.1. +"1.1.99.20","A quinoprotein. Acts on C3-C16 linear-chain saturated primary alcohols, C4-C7 aldehydes and on non-ionic surfactants containing polyethylene glycol residues, such as Tween 40 and 60, but not on methanol and only very slowly on ethanol. 2,6-Dichloroindophenol can act as acceptor. cf. EC 1.1.2.7, methanol dehydrogenase (cytochrome c) and EC 1.1.2.8, alcohol dehydrogenase (cytochrome c)." +"1.1.99.21",A flavoprotein (FAD). +"1.1.99.22","A quinoprotein. Also acts, more slowly, on a number of other polyols including D-sorbitol, D-arabinitol, meso-erythritol, ribitol and propane-1,2-diol." +"1.1.99.23","A quinoprotein. Phenazine methosulfate and 2,6-dichloroindophenol can act as acceptors. Also acts, more slowly, on 2-hexanol and some other secondary alcohols. cf. EC 1.1.99.8 alcohol dehydrogenase (acceptor) and EC 1.1.99.20 alkan-1-ol dehydrogenase (acceptor)." +"1.1.99.24","4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor." +"1.1.99.26","2,6-Dichloroindophenol and methylene blue can act as acceptors." +"1.1.99.27","High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound." +"1.1.99.28","D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. The ketose substrate must be in the open-chain form. The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. The enzyme from Zymomonas mobilis contains tightly bound NADP+." +"1.1.99.29","Requires FAD. A number of aldoses and ketoses in pyranose form, as well as glycosides, gluco-oligosaccharides, sucrose and lactose can act as a donor. 1,4-Benzoquinone or ferricenium ion (ferrocene oxidized by removal of one electron) can serve as acceptor. Unlike EC 1.1.3.10, pyranose oxidase, this fungal enzyme does not interact with O2 and exhibits extremely broad substrate tolerance with variable regioselectivity (C-3, C-2 or C-3 + C-2 or C-3 + C-4) for (di)oxidation of different sugars. D-Glucose is exclusively or preferentially oxidized at C-3 (depending on the enzyme source), but can also be oxidized at C-2 + C-3. The enzyme also acts on 1->4-alpha- and 1->4-beta-gluco-oligosaccharides, non-reducing gluco-oligosaccharides and L-arabinose, which are not substrates of EC 1.1.3.10. Sugars are oxidized in their pyranose but not in their furanose form." +"1.1.99.30","Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen." +"1.2.1.2","The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase." +"1.2.1.3","Wide specificity, including oxidation of D-glucuronolactone to D-glucarate." +"1.2.1.8","In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria. In contrast, different enzymes are involved in the first reaction. In plants, this reaction is catalysed by EC 1.14.15.7 (choline monooxygenase), whereas in animals and many bacteria it is catalysed by either membrane-bound EC 1.1.99.1 (choline dehydrogenase) or soluble EC 1.1.3.17 (choline oxidase) [5]. In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 (glycine/sarcosine N-methyltransferase) and EC 2.1.1.157 (sarcosine/dimethylglycine N-methyltransferase)." +"1.2.1.10","Also acts, more slowly, on glycolaldehyde, propanal and butanal. In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87, propanal dehydrogenase (propanoylating). Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. NADP+ can replace NAD+ but the rate of reaction is much slower [3]." +"1.2.1.12",Also acts very slowly on D-glyceraldehyde and some other aldehydes; thiols can replace phosphate. +"1.2.1.19","The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9]." +"1.2.1.20","The enzyme, characterized from multiple Pseudomonas strains, participates in L-lysine degradation. Unlike earlier claims, it prefers NADP+ to NAD+." +"1.2.1.23",Not identical with EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+). +"1.2.1.24","This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+." +"1.2.1.25","This enzyme system catalyses the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. It belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.104, pyruvate dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.4.1.27, glycine cleavage system, and EC 2.3.1.190, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The reaction catalysed by this system is the sum of three activities: EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), EC 2.3.1.168, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The system also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxopentanoate." +"1.2.1.27",Also converts 3-oxopropanoate into acetyl-CoA [3]. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding [3]. Bicarbonate rather than CO2 is released as a final product [3]. +"1.2.1.29","Oxidizes a number of aromatic aldehydes, but not aliphatic aldehydes." +"1.2.1.30","The enzyme contains an adenylation domain, a phosphopantetheinyl binding domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the phosphopantetheinyl binding domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to an aldehyde and released." +"1.2.1.31","(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction." +"1.2.1.32",Also acts on 2-hydroxymuconate semialdehyde. +"1.2.1.36",A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal. +"1.2.1.42","Also acts, more slowly, on octadecanoyl-CoA." +"1.2.1.43",A tungsten-selenium-iron protein. +"1.2.1.44",Acts also on a number of substituted cinnamoyl esters of coenzyme A. +"1.2.1.45","The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity." +"1.2.1.81",The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+. +"1.2.1.48",The best substrate is dodecylaldehyde. +"1.2.1.49",Not identical with EC 1.2.1.23 2-oxoaldehyde dehydrogenase (NAD+). +"1.2.1.50","Together with a hydrolase component (EC 3.1.2.2 and EC 3.1.2.14) and a synthetase component (EC 6.2.1.19), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme is acylated by receiving an acyl group from EC 6.2.1.19, and catalyses the reduction of the acyl group, releasing the aldehyde product. The enzyme is also able to accept the acyl group from a long-chain acyl-CoA." +"1.2.1.51","The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen." +"1.2.1.52","The Euglena enzyme can also use NAD+ as acceptor, but more slowly." +"1.2.1.53","With EC 4.2.1.87 octopamine dehydratase, brings about the metabolism of octopamine in Pseudomonas." +"1.2.1.54",Involved in the degradation of arginine in Pseudomonas putida (cf. EC 1.2.1.19 aminobutyraldehyde dehydrogenase). +"1.2.1.57","Also acts on acetaldehyde, but more slowly." +"1.2.1.58",Requires thiamine diphosphate as cofactor. The enzyme from the denitrifying bacterium Azoarcus evansii is specific for phenylglyoxylate. 2-Oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate. Also reduces viologen dyes. Contains iron-sulfur centres and FAD. +"1.2.1.59","NAD+ and NADP+ can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) and EC 1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), which are NAD+- and NADP+-dependent, respectively." +"1.2.1.60",Involved in the tyrosine degradation pathway in Arthrobacter sp. +"1.2.1.61",Involved in the 4-nitrophenol degradation pathway. +"1.2.1.62",Involved in the toluene-4-sulfonate degradation pathway. +"1.2.1.63",Last step in the cyclohexanol degradation pathway in Acinetobacter sp. +"1.2.1.64","The bacterial enzyme (characterized from an unidentified denitrifying bacterium) is involved in an anaerobic toluene degradation pathway. The plant enzyme is involved in formation of 4-hydroxybenzoate, a cell wall-bound phenolic acid that plays a major role in plant defense against pathogens. cf. EC 1.2.1.96, 4-hydroxybenzaldehyde dehydrogenase (NADP+)." +"1.2.1.65",Involved in the naphthalene degradation pathway in some bacteria. +"1.2.1.66",The S-formylmycothiol formed hydrolyses to mycothiol and formate. +"1.2.1.68","Also oxidizes other aromatic aldehydes, but not aliphatic aldehydes." +"1.2.1.69",The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde. +"1.2.1.70","This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway. The route shown in the diagram is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the alpha-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic alpha-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37." +"1.2.2.2",A flavoprotein requiring thiamine diphosphate. +"1.2.2.3","Yeast cytochrome c, ferricyanide and phenazine methosulfate can act as acceptor." +"1.2.2.4","Contains molybdopterin cytosine dinucleotide, FAD and [2Fe-2S]-clusters. Oxygen, methylene blue and iodonitrotetrazolium chloride can act as nonphysiological electron acceptors." +"1.2.3.1","Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme, retinal oxidase (formerly EC 1.2.3.11) [5,7]." +"1.2.3.3","A flavoprotein (FAD) requiring thiamine diphosphate. Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin. FADH2 is reoxidized by O2 to yield H2O2 and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate [2]." +"1.2.3.4",Contains Mn2+ as a cofactor. The enzyme is not a flavoprotein as had been thought [3]. +"1.2.3.6",A flavoprotein (FAD). May be identical with EC 1.2.7.1 pyruvate synthase. +"1.2.3.7","A hemoprotein. This enzyme is an isoform of aldehyde oxidase (EC 1.2.3.1). It has a preference for aldehydes having an indole-ring structure as substrate [6,7]. It may play a role in plant hormone biosynthesis as its activity is higher in the auxin-overproducing mutant, super-root1, than in wild-type Arabidopsis thaliana [7]. While (indol-3-yl)acetaldehyde is the preferred substrate, it also oxidizes indole-3-carbaldehyde and acetaldehyde, but more slowly. The enzyme from maize contains FAD, iron and molybdenum [4]." +"1.2.3.8",A molybdenum protein. +"1.2.3.9","Acts on benzaldehyde, vanillin and a number of other aromatic aldehydes, but not on aliphatic aldehydes or sugars." +"1.2.3.11","May be the same as EC 1.2.3.1, aldehyde oxidase." +"1.2.3.13",Involved in tyrosine degradation pathway in Arthrobacter sp. +"1.2.3.14","Acts on both (+)- and (-)-abscisic aldehyde. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.1.1.288, (xanthoxin dehydrogenase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.14.137 [(+)-abscisic acid 8'-hydroxylase]. While abscisic aldehyde is the best substrate, the enzyme also acts with indole-3-aldehyde, 1-naphthaldehyde and benzaldehyde as substrates, but more slowly [3]." +"1.2.4.1","Contains thiamine diphosphate. It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex, EC 1.2.1.104, in which it is bound to a core of molecules of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12." +"1.2.4.2","Contains thiamine diphosphate. It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex, EC 1.2.1.105, in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, dihydrolipoyllysine-residue succinyltransferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61." +"1.2.4.4","Contains thiamine diphosphate. It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2-oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine. It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168." +"1.2.7.1","Contains thiamine diphosphate and [4Fe-4S] clusters. The enzyme also decarboxylates 2-oxobutyrate with lower efficiency, but shows no activity with 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)." +"1.2.7.3","The enzyme contains thiamine diphosphate and two [4Fe-4S] clusters. Highly specific for 2-oxoglutarate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)." +"1.2.7.4","This prokaryotic enzyme catalyses the reversible reduction of CO2 to CO. The electrons are transferred to redox proteins such as ferredoxin. In purple sulfur bacteria and methanogenic archaea it catalyses the oxidation of CO to CO2, which is incorporated by the Calvin-Benson-Basham cycle or released, respectively. In acetogenic and sulfate-reducing microbes it catalyses the reduction of CO2 to CO, which is incorporated into acetyl CoA by EC 2.3.1.169, CO-methylating acetyl-CoA synthase, with which the enzyme forms a tight complex in those organisms. The enzyme contains five metal clusters per homodimeric enzyme: two nickel-iron-sulfur clusters called the C-Clusters, one [4Fe-4S] D-cluster; and two [4Fe-4S] B-clusters. In methanogenic archaea additional [4Fe-4S] clusters exist, presumably as part of the electron transfer chain. In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S protein EC 1.12.7.2, ferredoxin hydrogenase, which catalyse the overall reaction: CO + H2O = CO2 + H2. cf. EC 1.2.5.3, aerobic carbon monoxide dehydrogenase." +"1.2.7.5","This is an oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters. Catalyses the oxidation of aldehydes (including crotonaldehyde, acetaldehyde, formaldehyde and glyceraldehyde) to their corresponding acids. However, it does not oxidize glyceraldehyde 3-phosphate [see EC 1.2.7.6, glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)]. Can use ferredoxin or methyl viologen but not NAD(P)+ as electron acceptor." +"1.2.7.6",Contains tungsten-molybdopterin and iron-sulfur clusters. This enzyme is thought to function in place of glyceralde-3-phosphate dehydrogenase and possibly phosphoglycerate kinase in the novel Embden-Meyerhof-type glycolytic pathway found in Pyrococcus furiosus [1]. It is specific for glyceraldehyde-3-phosphate. +"1.2.7.7","The enzyme is CoA-dependent and contains thiamine diphosphate and iron-sulfur clusters. Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo-pentanoate, and 2-oxobutanoate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that reversibly catalyse the oxidative decarboxylation of different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase, and EC 1.2.7.3, 2-oxoglutarate synthase." +"1.2.7.8","Contains thiamine diphosphate and [4Fe-4S] clusters. Preferentially utilizes the transaminated forms of aromatic amino acids and can use phenylpyruvate and p-hydroxyphenylpyruvate as substrates. This enzyme, which is found in archaea, is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)." +"1.2.99.2","Contains a [Ni3Fe-4S] cluster and [4Fe-4S] clusters. It uses many electron acceptors, including ferredoxin, methyl viologen and benzyl viologen and flavins, but not pyridine nucleotides. Forms part of a membrane-bound multienzyme complex with EC 1.12.99.6, hydrogenase (acceptor), which catalyses the overall reaction: CO + H2O = CO2 + H2." +"1.2.99.3","A quinoprotein. Wide specificity; acts on straight-chain aldehydes up to C10, aromatic aldehydes, glyoxylate and glyceraldehyde." +"1.2.99.4","The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. The enzyme from Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, NDMA-dependent alcohol dehydrogenase and EC 1.1.99.37, NDMA-dependent methanol dehydrogenase [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2]." +"1.2.99.5","A molybdoprotein containing a pterin cofactor. Tungstate can substitute for molybdate. The enzyme catalyses a reversible reaction in methanogenic bacteria, and is involved in methanogenesis from CO2 as well as the oxidation of methyl-coenzyme M to CO2. Methylviologen can act as acceptor. Also oxidizes N-furfurylformamide." +"1.2.99.6","A tungsten protein. Methyl viologen can act as acceptor. In the reverse direction, non-activated acids are reduced by reduced viologens to aldehydes, but not to the corresponding alcohols." +"1.2.99.7","Belongs to the xanthine oxidase family of enzymes. The enzyme from Desulfovibrio sp. contains a molybdenum-molybdopterin-cytosine dinucleotide (MCD) complex and two types of [2Fe-2S] cluster per monomer, but does not contain FAD." +"1.3.1.1","An iron-sulfur flavoenzyme. The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth [1]. Since then the enzyme was found in additional organisms including Alcaligenes eutrophus [2], Pseudomonas strains [3,4] and Escherichia coli [5,6]." +"1.3.1.2",Also acts on dihydrothymine. +"1.3.1.3","The enzyme from human efficiently catalyses the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent [8]. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3-one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates [9]." +"1.3.1.5",Requires Mn2+. Fe2+ or Zn2+ can replace Mn2+ to some extent. +"1.3.1.8","The liver enzyme acts on enoyl-CoA derivatives of carbon chain length 4 to 16, with optimum activity on 2-hexenoyl-CoA. In Escherichia coli, cis-specific and trans-specific enzymes exist [EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) and EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)]." +"1.3.1.9","The enzyme catalyses an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier-protein] derivatives of the elongating fatty acid moiety. The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18 [3]. The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons." +"1.3.1.10","One of the activities of EC 2.3.1.86, fatty-acyl-CoA synthase system, an enzyme found in yeasts (Ascomycota and Basidiomycota). Catalyses the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16. The yeast enzyme is Si-specific with respect to NADP+. cf. EC 1.3.1.39, enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 1.3.1.104, enoyl-[acyl-carrier-protein] reductase (NADPH), which describes enzymes whose stereo-specificity towards NADPH is not known. See also EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)." +"1.3.1.12",This enzyme in the enteric bacteria also possesses chorismate mutase activity (EC 5.4.99.5 chorismate mutase) and converts chorismate into prephenate. +"1.3.1.14","Binds FMN, FAD and a [2Fe-2S] cluster. The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit [4]. The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor." +"1.3.1.15",Binds FMN and FAD [2]. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor . +"1.3.1.21",The enzyme is part of the cholesterol biosynthesis pathway. +"1.3.1.22","The enzyme catalyses the conversion of assorted 3-oxo-Delta4 steroids into their corresponding 5alpha form. Substrates for the mammalian enzyme include testosterone, progesterone, and corticosterone. Substrates for the plant enzyme are brassinosteroids such as campest-4-en-3-one and (22alpha)-hydroxy-campest-4-en-3-one. cf. EC 1.3.99.5, 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)." +"1.3.1.27","Specific for long chain 2-trans- and 2-cis-alkenals, with chain length optimum around 14 to 16 carbon atoms." +"1.3.1.29","Also acts, at half the rate, on cis-anthracene dihydrodiol and cis-phenanthrene dihydrodiol." +"1.3.1.30",Testosterone and 20alpha-hydroxy-4-pregn-3-one can act in place of progesterone. +"1.3.1.31",An iron-sulfur-flavoprotein (FAD). Acts (in the reverse direction) on a wide range of alkyl and aryl alphabeta-unsaturated carboxylate ions; but-2-enoate was the best substrate tested. +"1.3.1.33","The enzyme catalyses a light-dependent trans-reduction of the D-ring of protochlorophyllide; the product has the (7S,8S)-configuration." +"1.3.1.34","This bacterial enzyme catalyses the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (2E)-2-enoyl-CoA. The enzyme from Escherichia coli contains FAD, FMN, and an [4Fe-4S] iron sulfur cluster. cf. EC 1.3.1.124, 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]." +"1.3.1.35",Also desaturates phosphatidylcholine containing the oleoyl group on O-2 of the glycerol residue. +"1.3.1.36",Involved in the interconversion of heteroyohimbine alkaloids in Catharanthus roseus. +"1.3.1.37",Not identical with EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)]. +"1.3.1.38",Not identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)]. +"1.3.1.39","This enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl-carrier protein. It is one of the activities of EC 2.3.1.85, fatty-acid synthase system. The mammalian enzyme is Re-specific with respect to NADP+. cf. EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.104, enoyl-[acyl-carrier-protein] reductase (NADPH)." +"1.3.1.40",Broad specificity; reduces a number of compounds produced by Pseudomonas from aromatic hydrocarbons by ring fission. +"1.3.1.41",From Drosophila melanogaster. +"1.3.1.42","The enzyme catalyses the reduction of (9S,13S,15Z)-12-oxophyto-10,15-dienoate during the biosynthesis of jasmonate from alpha-linolenate in Zea mays." +"1.3.1.43","Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NAD+-specific enzymes have been reported from some bacteria [2] and plants [3]. Some enzymes also possess the activity of EC 1.3.1.12, prephenate dehydrogenase." +"1.3.1.44","The enzyme from Euglena gracilis acts on crotonoyl-CoA and, more slowly, on trans-hex-2-enoyl-CoA and trans-oct-2-enoyl-CoA." +"1.3.1.45","In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an isoflavanone; 2'-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain." +"1.3.1.46",Some other isoflavones are reduced to the corresponding isoflavanones. +"1.3.1.48","Reduces 13,14-dehydro-15-oxoprostaglandins to 13,14-dihydro derivatives. The enzyme from placenta is specific for NAD+." +"1.3.1.51","In the reverse reaction, the 2'-hydroxyisoflavone (2'-hydroxydaidzein) is reduced to an isoflavanone. Also acts on 2'-hydroxyformononetin and to a small extent on 2'-hydroxygenistein. Involved in the biosynthesis of the phytoalexin glyceollin. The isoflavones biochanin A, daidzein and genestein as well as the flavonoids apigenin, kaempferol and quercetin do not act as substrates." +"1.3.1.52",A flavoprotein (FAD) from Ascaris suum. The reaction proceeds only in the presence of another flavoprotein ('electron-transferring flavoprotein'). +"1.3.1.53",Requires FeII. Involved in the terephthalate degradation pathway in bacteria [2]. +"1.3.1.54","The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of precorrin-6A. See EC 1.3.1.106, cobalt-precorrin-6A reductase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway." +"1.3.1.56",Catalyses the second step in the biphenyl degradation pathway in bacteria. +"1.3.1.57",Involved in the gallate anaerobic degradation pathway in bacteria. +"1.3.1.58",Involved in the p-cymene degradation pathway in Pseudomonas putida. +"1.3.1.59",Involved in the m-xylene degradation pathway in bacteria. +"1.3.1.60",Involved in the dibenzothiophene degradation pathway in bacteria. +"1.3.1.61",Involved in the terephthalate degradation pathway in bacteria. +"1.3.1.62",Involved in the benzoate degradation (anaerobic) pathway in bacteria. +"1.3.1.63","Acts in the reverse direction to form part of the 2,4-dichlorobenzoate degradation pathway in bacteria." +"1.3.1.64",Involved in the phthalate degradation pathway in bacteria. +"1.3.1.65",Acts in the reverse direction to form part of the 3-methylquinoline degradation pathway in bacteria. +"1.3.1.66",Involved in the ethylbenzene degradation pathway in bacteria. +"1.3.1.67",Involved in the p-xylene degradation pathway in bacteria. +"1.3.1.68",Involved in the o-xylene degradation pathway in bacteria. +"1.3.1.69",Previously classified erroneously as EC 1.1.1.242. +"1.3.1.70",This enzyme acts on a range of steroids with a 14(15)-double bond. +"1.3.1.71",Acts on a range of steroids with a 24(241)-double bond. +"1.3.1.72","Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol." +"1.3.1.73","The enzyme, characterized from the plant Rauvolfia serpentina, participates in the ajmaline biosynthesis pathway. It has a much lower activity on vomilenine." +"1.3.1.74","Highly specific for 4-hydroxynon-2-enal and non-2-enal. Alk-2-enals of shorter chain have lower affinities. Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones [cf. EC 1.3.1.102, 2-alkenal reductase (NADP+)]." +"1.3.1.75","The enzyme, found in higher plants, green algae, and some phototrophic bacteria, is involved in the production of monovinyl versions of (bacterio)chlorophyll pigments from their divinyl precursors. It can also act on 3,8-divinyl chlorophyllide a. cf. EC 1.3.7.13, 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin)." +"1.3.1.76","This enzyme catalyses the second of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107, uroporphyrin-III C-methyltransferase) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction." +"1.3.1.77","The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming]." +"1.3.1.78","Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3]." +"1.3.1.79","Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans." +"1.3.2.3","This enzyme catalyses the final step in the biosynthesis of L-ascorbic acid in higher plants and in nearly all higher animals with the exception of primates and some birds [5]. The enzyme is very specific for its substrate L-galactono-1,4-lactone as D-galactono-gamma-lactone, D-gulono-gamma-lactone, L-gulono-gamma-lactone, D-erythronic-gamma-lactone, D-xylonic-gamma-lactone, L-mannono-gamma-lactone, D-galactonate, D-glucuronate and D-gluconate are not substrates [5]. FAD, NAD+, NADP+ and O2 (cf. EC 1.3.3.12, L-galactonolactone oxidase) cannot act as electron acceptor [5]." +"1.3.3.1","A flavoprotein (FAD, FMN). Ferricyanide can act as acceptor." +"1.3.3.4",This is the last common enzyme in the biosynthesis of chlorophylls and heme [8]. Two isoenzymes exist in plants: one in plastids and the other in mitochondria. This is the target enzyme of phthalimide-type and diphenylether-type herbicides [8]. The enzyme from oxygen-dependent species contains FAD [9]. Also slowly oxidizes mesoporphyrinogen IX. +"1.3.3.6",A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18. +"1.3.3.7",Also oxidizes dihydrothymine to thymine. A flavoprotein (FMN). +"1.3.3.8",The enzyme from Berberis sp. is a flavoprotein; that from Coptis japonica is not. (R)-Tetrahydroberberines are not oxidized. +"1.3.3.9",A heme-thiolate protein (P-450). Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids. +"1.3.3.10","Requires heme. The enzyme from Chromobacterium violaceum is specific for tryptophan derivatives possessing its carboxyl group free or as an amide or ester, and an unsubstituted indole ring. Also catalyses the alpha,beta dehydrogenation of L-tryptophan side chains in peptides. The product of the reaction can hydrolyse spontaneously to form (indol-3-yl)pyruvate." +"1.3.3.11","So far only a single turnover of the enzyme has been observed, and the pyrroloquinoline quinone remains bound to it. It is not yet known what releases the product in the bacterium." +"1.3.5.1","A complex generally comprising an FAD-containing component that also binds the carboxylate substrate (A subunit), a component that contains three different iron-sulfur centers [2Fe-2S], [4Fe-4S], and [3Fe-4S] (B subunit), and a hydrophobic membrane-anchor component (C, or C and D subunits) that is also the site of the interaction with quinones. The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of bacteria and archaea, with the hydrophilic domain extending into the mitochondrial matrix and the cytoplasm, respectively. Under aerobic conditions the enzyme catalyses succinate oxidation, a key step in the citric acid (TCA) cycle, transferring the electrons to quinones in the membrane, thus linking the TCA cycle with the aerobic respiratory chain (where it is known as complex II). Under anaerobic conditions the enzyme functions as a fumarate reductase, transferring electrons from the quinol pool to fumarate, and participating in anaerobic respiration with fumarate as the terminal electron acceptor. The enzyme interacts with the quinone produced by the organism, such as ubiquinone, menaquinone, caldariellaquinone, thermoplasmaquinone, rhodoquinone etc. Some of the enzymes contain two heme subunits in their membrane anchor subunit. These enzymes catalyse an electrogenic reaction and are thus classified as EC 7.1.1.12, succinate dehydrogenase (electrogenic, proton-motive force generating)." +"1.3.7.2","Catalyses the two-electron reduction of biliverdin IXalpha at the C15 methine bridge. It has been proposed that this enzyme and EC 1.3.7.3, phycoerythrobilin:ferredoxin oxidoreductase, function as a dual enzyme complex in the conversion of biliverdin IXalpha into phycoerythrobilin." +"1.3.7.3","Catalyses the two-electron reduction of the C2 and C31 diene system of 15,16-dihydrobiliverdin. Specific for 15,16-dihydrobiliverdin. It has been proposed that this enzyme and EC 1.3.7.2, 15,16-dihydrobiliverdin:ferredoxin oxidoreductase, function as a dual enzyme complex in the conversion of biliverdin IXalpha to phycoerythrobilin." +"1.3.7.4",Catalyses the two-electron reduction of biliverdin IXalpha. Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum. The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm. Flavodoxins can be used instead of ferredoxin. +"1.3.7.5","Catalyses the four-electron reduction of biliverdin IXalpha (2-electron reduction at both the A and D rings). Reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Flavodoxins can be used instead of ferredoxin. The direct conversion of biliverdin IXalpha (BV) to (3Z)-phycocyanolbilin (PCB) in the cyanobacteria Synechocystis sp. PCC 6803, Anabaena sp. PCC7120 and Nostoc punctiforme is in contrast to the proposed pathways of PCB biosynthesis in the red alga Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as an intermediate [2] and in the green alga Mesotaenium caldariorum, in which PCB is an isolable intermediate." +"1.3.99.1",A flavoprotein (FAD) containing iron-sulfur centres. A component of EC 1.3.5.1 succinate dehydrogenase (ubiquinone). +"1.3.99.2","A flavoprotein; forms, with another flavoprotein ('electron-transferring flavoproteins') and EC 1.5.5.1 electron-transferring-flavoprotein dehydrogenase, a system reducing ubiquinone and other acceptors." +"1.3.99.3","A flavoprotein; forms, with another flavoprotein ('electron-transferring flavoprotein') and EC 1.5.5.1 electron-transferring-flavoprotein dehydrogenase, a system reducing ubiquinone and other acceptors. " +"1.3.99.5","A flavoprotein. This bacterial enzyme, characterized from Comamonas testosteroni, is involved in androsterone degradation. cf. EC 1.3.1.22, 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)." +"1.3.99.7",A flavoprotein. +"1.3.99.8","A copper protein. The oxygen atom of the -OH produced is derived from water, not O2; the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH2- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH2-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors." +"1.3.99.10","A flavoprotein; forms with electron-transferring flavoprotein and EC 1.5.5.1 (electron-transferring-flavoprotein dehydrogenase) a system reducing ubiquinone. n-Pentanoate can act as donor. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.99.3 (acyl-CoA dehydrogenase) or EC 1.3.99.12 (2-methylacyl-CoA dehydrogenase)." +"1.3.99.11","An iron-zinc protein. Oxygen can act as acceptor, but much more slowly than 2,6-dichloroindophenol or 1,10-phenanthroline." +"1.3.99.12","Also oxidizes 2-methylpropanoyl-CoA. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.8.7 (medium-chain acyl-CoA dehydrogenase), EC 1.3.8.8 (long-chain acyl-CoA dehydrogenase), EC 1.3.8.9 (very-long-chain acyl-CoA dehydrogenase) or EC 1.3.99.10 (isovaleryl-CoA dehydrogenase)." +"1.3.99.13","A flavoprotein (FAD); forms with another flavoprotein ('electron-transferring flavoprotein') and EC 1.5.5.1 a system reducing ubiquinone and other acceptors. Not identical with EC 1.3.8.1 (butyryl-CoA dehydrogenase), EC 1.3.99.3 (acyl-CoA dehydrogenase), EC 1.3.99.10 (isovaleryl-CoA dehydrogenase) or EC 1.3.99.12 (2-methylacyl-CoA dehydrogenase)." +"1.3.99.14","2,6-Dichloroindophenol can act as acceptor. The corresponding ketones of cyclopentane and cycloheptane cannot act as donors." +"1.3.99.15","An iron-sulfur protein. Requires Mg2+ or Mn2+. Reduced methyl viologen can act as electron donor. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate + H2O = hydroxylamine + reduced acceptor + 2 ATP. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate." +"1.3.99.16","The enzyme from Pseudomonas diminuta is specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors include 1,2-benzoquinone, cytochrome c, ferricyanide, iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue and phenazine methosulfate." +"1.3.99.17","Quinolin-2-ol, quinolin-7-ol, quinolin-8-ol, 3-, 4- and 8-methylquinolines and 8-chloroquinoline are substrates. Iodonitrotetrazolium chloride can act as an electron acceptor." +"1.3.99.18","The enzyme from Pseudomonas sp. AK2 also acts on quinoline-8-carboxylate, whereas that from Serratia marcescens 2CC-1 will oxidize nicotinate; quinaldate is a substrate for both of these enzymes. 2,4,6-Trinitrobenzene sulfonate, 1,4-benzoquinone, 1,2-naphthoquinone, nitroblue tetrazolium, thionine and menadione will serve as an electron acceptor for the former enzyme and ferricyanide for the latter; Meldola blue, iodonitrotetrazolium chloride, phenazine methosulfate, 2,6-dichlorophenolindophenol and cytochrome c will act as electron acceptors for both." +"1.3.99.19","A molybdenum---iron---sulfur flavoprotein with molybdopterin cytosine dinucleotide as the molybdenum cofactor. Quinoline, 4-methylquinoline and 4-chloroquinoline can also serve as substrates for the enzyme from Agrobacterium sp. 1B. Iodonitrotetrazolium chloride, thionine, menadione and 2,6-dichlorophenolindophenol can act as electron acceptors." +"1.3.99.20",A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3] +"1.3.99.21","Requires FAD as cofactor. The enzyme is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Uses the ferricenium ion as the preferred artificial electron acceptor. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity." +"1.3.99.22","This enzyme differs from EC 1.3.3.3, coproporphyrinogen oxidase, by using S-adenosyl-L-methionine (AdoMet) instead of oxygen as oxidant. It occurs mainly in bacteria, whereas eukaryotes use the oxygen-dependent oxidase. The reaction starts by using an electron from the reduced form of the enzyme's [4Fe-4S] cluster to split AdoMet into methionine and the radical 5'-deoxyadenosin-5'-yl. This radical initiates attack on the 2-carboxyethyl groups, leading to their conversion into vinyl groups. This conversion, ---(.)CH-CH2-COO- -> ---CH=CH2 + CO2 + e- replaces the electron initially used." +"1.3.99.23","The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A." +"1.4.1.5",Acts on aliphatic amino acids. +"1.4.1.9","Also acts on isoleucine, valine, norvaline and norleucine." +"1.4.1.12","Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)]." +"1.4.1.13","Binds FMN, FAD, 2 [4Fe-4S] clusters and 1 [3Fe-4S] cluster. The reaction takes place in the direction of L-glutamate production. The protein is composed of two subunits, alpha and beta. The alpha subunit is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.4, glutamate dehydrogenase [NADP+]). The beta subunit transfers electrons from the cosubstrate. The NH3 is channeled within the alpha subunit through a 31 A channel. The chanelling is very efficient and in the intact alpha-beta complex ammonia is produced only within the complex. In the absence of the beta subunit, coupling between the two domains of the alpha subunit is compromised and some ammonium can leak. " +"1.4.1.14","A flavoprotein (FMN). The reaction takes place in the direction of L-glutamate production. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.2, glutamate dehydrogenase). " +"1.4.1.18","The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4]." +"1.4.1.19",Activated by Ca2+. +"1.4.1.20",The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine. +"1.4.1.21","The enzyme is strictly specific for L-aspartate as substrate. It produces the unstable compound 2-iminosuccinate, which, in the presence of water, hydrolyses spontaneously to form oxaloacetate. The enzyme from some archaea and thermophilic bacteria is likely to transfer 2-iminosuccinate directly to EC 2.5.1.72, quinolinate synthase, preventing its hydrolysis and enabling the de novo biosynthesis of NAD+." +"1.4.3.1",A flavoprotein (FAD). +"1.4.3.2",A flavoprotein (FAD). +"1.4.3.3",A flavoprotein (FAD). Wide specificity for D-amino acids. Also acts on glycine. +"1.4.3.4","A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [3]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22 (diamine oxidase), it is not inhibited by semicarbazide." +"1.4.3.5","A flavoprotein (FMN). In Escherichia coli, the cofactor pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). N4'-Substituted pyridoxamine derivatives are also oxidized in reaction (1) to form pyridoxal 5-phosphate and the corresponding primary amine." +"1.4.3.6","A group of enzymes including those oxidizing primary monoamines, diamines and histamine. They are copper quinoproteins. One form of EC 1.3.1.15 orotate reductase (NADPH) from rat kidney also catalyses this reaction." +"1.4.3.8",A cobamide-protein. +"1.4.3.10",A flavoprotein (FAD). 4-Aminobutanal condenses non-enzymically to 1-pyrroline. +"1.4.3.11","A flavoprotein (FAD).The enzyme from Azotobacter previously listed under this number, which did not produce H2O2, was a crude cell-free extract that probably contained catalase." +"1.4.3.12","A flavoprotein (FAD). Some other cyclic amines can act instead of cyclohexylamine, but not simple aliphatic and aromatic amides." +"1.4.3.13","Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5]. Some isoforms can also use [protein]-N(6)-acetyl-L-lysine as substrate deacetamidating the substrate [6]. " +"1.4.3.14","Also acts, more slowly, on L-ornithine, L-phenylalanine, L-arginine and L-histidine." +"1.4.3.15","A flavoprotein (FAD). D-Glutamate and D-aspartate are oxidized at the same rate. Other D-monoaminodicarboxylates, and other D- and L-amino acids, are not oxidized. cf. EC 1.4.3.7, D-glutamate oxidase and EC 1.4.3.1, D-aspartate oxidase." +"1.4.3.16","A flavoprotein (FAD). L-Aspartate oxidase catalyses the first step in the de novo biosynthesis of NAD+ in some bacteria. O2 can be replaced by fumarate as electron acceptor, yielding succinate [5]. The ability of the enzyme to use both O2 and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions [5]. Iminosuccinate can either be hydrolysed to form oxaloacetate and NH3 or can be used by EC 2.5.1.72, quinolinate synthase, in the production of quinolinate. The enzyme is a member of the succinate dehydrogenase/fumarate-reductase family of enzymes [5]. " +"1.4.3.19","A flavoenzyme containing non-covalently bound FAD. The enzyme from Bacillus subtilis is active with glycine, sarcosine, N-ethylglycine, D-alanine, D-alpha-aminobutyrate, D-proline, D-pipecolate and N-methyl-D-alanine. It differs from EC 1.4.3.3, D-amino-acid oxidase, due to its activity on sarcosine and D-pipecolate. The intermediate 2-iminoacetate is used directly by EC 2.8.1.10, thiazole synthase." +"1.4.4.2","A pyridoxal-phosphate protein. A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10, aminomethyltransferase), the L protein (EC 1.8.1.4, dihydrolipoyl dehydrogenase) and the lipoyl-bearing H protein [3]. Previously known as glycine synthase." +"1.4.7.1","Binds a [3Fe-4S] cluster as well as FAD and FMN. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate. The NH3 is channeled through a 24 A channel in the active protein. No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein [5,6]." +"1.4.99.1","A flavoprotein (FAD). Acts to some extent on all D-amino acids, except D-aspartate and D-glutamate." +"1.4.99.3",A quinoprotein. +"1.4.99.4","Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine (cf. EC 1.4.99.3 amine dehydrogenase)." +"1.4.99.5","The enzyme from Pseudomonas sp. contains FAD. The enzyme is membrane-bound, and the 2-electron acceptor is a component of the respiratory chain. The enzyme can act with various artificial electron acceptors, including phenazine methosulfate." +"1.5.1.1","The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH." +"1.5.1.2",Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline. +"1.5.1.3","The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate." +"1.5.1.5","In eukaryotes, occurs as a trifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and formate---tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes occurs as a bifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase activity (EC 3.5.4.9)." +"1.5.1.9","The activities of this enzyme along with EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming), occur on a single protein." +"1.5.1.11","In the reverse direction, acts also on L-ornithine, L-lysine and L-histidine." +"1.5.1.12","This enzyme catalyses the irreversible oxidation of glutamate-gamma-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.99.8, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity [5]." +"1.5.1.16","In the reverse reaction, a number of L-amino acids can act instead of L-lysine, and 2-oxobutanoate and, to a lesser extent, glyoxylate can act instead of pyruvate." +"1.5.1.17","In the reverse reaction, L-alanine can be replaced by L-cysteine, L-serine or L-threonine; glycine acts very slowly (cf. EC 1.5.1.22 strombine dehydrogenase)." +"1.5.1.18","The product immediately hydrolyses to methylamine and 1-hydroxy-1-phenylpropan-2-one. Acts on a number of related compounds including (-)-sympatol, (+)-pseudoephedrine and (+)-norephedrine." +"1.5.1.19","In the reverse direction, forms D-nopaline from L-arginine and D-ornaline from L-ornithine." +"1.5.1.20","A flavoprotein (FAD). The enzyme catalyses the reversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. This enzyme, characterized from Protozoan parasites of the genus Leishmania, is unique among similar characterized eukaryotic enzymes in that it lacks the C-terminal allosteric regulatory domain (allowing it to catalyse a reversible reaction) and uses NADH and NADPH with equal efficiency under physiological conditions. cf. EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin)." +"1.5.1.53","A flavoprotein (FAD). The enzyme from yeast and mammals catalyses a physiologically irreversible reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADPH as the electron donor. It plays an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. The enzyme contains an N-terminal catalytic domain and a C-terminal allosteric regulatory domain that binds S-adenosyl-L-methionine, which acts as an inhibitor. cf. EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin)." +"1.5.1.21","The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH." +"1.5.1.22","Also catalyses the reaction of EC 1.5.1.17 alanopine dehydrogenase, but more slowly. Does not act on L-strombine." +"1.5.1.23","In the reverse reaction, alanine can act instead of taurine, but more slowly, and 2-oxobutanoate and 2-oxopentanoate can act instead of pyruvate." +"1.5.1.24","In the reverse direction, L-lysine can act instead of L-ornithine, but more slowly. Acts on the amino group. cf. EC 1.5.1.16, D-lysopine dehydrogenase." +"1.5.1.25","The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, but more slowly." +"1.5.1.27","Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions." +"1.5.1.28","In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate." +"1.5.1.29","Catalyses the reduction of soluble flavins by reduced pyridine nucleotides. Highest activity with riboflavin. When NADH is used as acceptor, the enzyme can also utilize FMN and FAD as substrates, with lower activity than riboflavin. When NADPH is used as acceptor, the enzyme has a very low activity with FMN and no activity with FAD [1]." +"1.5.1.30","The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH." +"1.5.1.31","Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC 1.3.3.8 tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine." +"1.5.1.32","The enzyme, characterized from the plant Rauvolfia serpentina, participates in the ajmaline biosynthesis pathway." +"1.5.1.33","The enzyme from Leishmania (both amastigote and promastigote forms) catalyses the reduction by NADPH of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms. It also catalyses the reduction of 7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms. In contrast to EC 1.5.1.3 (dihydrofolate reductase) and EC 1.5.1.34 (6,7-dihydropteridine reductase), pteridine reductase will not catalyse the reduction of the quinonoid form of dihydrobiopterin. The enzyme is specific for NADPH; no activity has been detected with NADH. It also differs from EC 1.5.1.3 (dihydrofolate reductase) in being specific for the Si-face of NADPH." +"1.5.1.34",The substrate is the quinonoid form of dihydropteridine. Not identical with EC 1.5.1.3 dihydrofolate reductase. +"1.5.3.1","The enzyme, reported from bacteria and fungi, catalyses the oxidative demethylation of sarcosine. It contains a FAD cofactor bound to an L-cysteine residue. cf. EC 1.5.3.24, sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)." +"1.5.3.2",A flavoprotein. +"1.5.3.5","A flavoprotein (FAD). The enzyme, which participates in nicotine degradation, is specific for the (S) isomer of 6-hydroxynicotine. The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyses a similar reaction with the less common (R)-isomer (cf. EC 1.5.3.6, (R)-6-hydroxynicotine oxidase)." +"1.5.3.6","A flavoprotein (FAD). The enzyme, which participates in nicotine degradation, is specific for (R) isomer of 6-hydroxynicotine, derived from the uncommon (R)-nicotine. The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyses a similar reaction with the (S)-isomer (cf. EC 1.5.3.5, (S)-6-hydroxynicotine oxidase)." +"1.5.3.7",The product reacts with water to form (S)-2-amino-6-oxohexanoate. +"1.5.3.10","A flavoprotein (FAD). The enzyme, characterized from the bacterium Arthrobacter globiformis, contains two active sites connected by a large ""reaction chamber"". An imine intermediate is transferred between the sites, eliminating the production of toxic formaldehyde. In the absence of folate the enzyme does form formaldehyde. Does not oxidize sarcosine. cf. EC 1.5.8.4, dimethylglycine dehydrogenase." +"1.5.3.11","A flavoprotein requiring Fe2+. Also acts on N1-acetylspermidine and N1,N12-diacetylspermine." +"1.5.3.12",A CuII enzyme found in higher plants that produces oxidized forms of the benzophenanthridine alkaloids +"1.5.4.1","In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster." +"1.5.5.1","An iron-sulfur flavoprotein, forming part of the mitochondrial electron-transfer system." +"1.5.7.1","An iron-sulfur flavoprotein that also contains zinc. The enzyme from Clostridium formicoaceticum catalyses the reduction of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or FADH2 with 5,10-methylenetetrahydrofolate. However, unlike EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.54, methylenetetrahydrofolate reductase (NADH); or EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H], there is no activity with either NADH or NADP+." +"1.5.8.1",Contains FAD and a [4Fe-4S] cluster. +"1.5.8.2","A number of alkyl-substituted derivatives of trimethylamine can also act as electron donors; phenazine methosulfate and 2,6-dichloroindophenol can act as electron acceptors. Contains FAD and a [4Fe-4S] cluster." +"1.5.99.1",A flavoprotein (FMN). +"1.5.99.2",A flavoprotein. +"1.5.99.3",The product reacts with water to form (S)-2-amino-6-oxohexanoate. +"1.5.99.4","A metalloprotein (FMN). The enzyme can act on both the naturally found (S)-enantiomer and the synthetic (R)-enantiomer of nicotine, with retention of configuration in both cases [4]." +"1.5.99.5","A number of N-methyl-substituted amino acids can act as donor; 2,6-dichloroindophenol is the best acceptor." +"1.5.99.6","A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline." +"1.5.99.8","A flavoprotein (FAD). In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88, L-glutamate gamma-semialdehyde dehydrogenase [2]. Both activities are carried out by the same enzyme in enterobacteria [2,3]." +"1.5.99.9","Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum." +"1.5.99.11",Catalyses an intermediate step in methanogenesis from CO2 and H2 in bacteria. +"1.5.99.12","A flavoprotein (FAD). Catalyses the oxidation of cytokinins, a family of N6-substituted adenine derivatives that are plant hormones, where the substituent is a prenyl group. Although this activity was previously thought to be catalysed by a hydrogen-peroxide-forming oxidase, this enzyme does not require oxygen for activity and does not form hydrogen peroxide. 2,6-Dichloroindophenol, methylene blue, nitroblue tetrazolium, phenazine methosulfate and copper(II) in the presence of imidazole can act as acceptors. This enzyme plays a part in regulating rice-grain production, with lower levels of the enzyme resulting in enhanced grain production [2]." +"1.6.1.1","The enzyme from Azotobacter vinelandii is a flavoprotein (FAD). It is Si-specific with respect to both NAD+ and NADP+. See EC 1.6.1.3, NAD(P)+ transhydrogenase, for enzymes whose stereo specificity is not known." +"1.6.1.2",The enzyme from heart mitochondria is Re-specific with respect to NAD+ and Si-specific with respect to NADP+ [cf. EC 1.6.1.1 NAD(P)+ transhydrogenase (Si-specific)]. +"1.6.2.2",A flavoprotein (FAD). +"1.6.2.4","A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases (e.g. EC 1.14.14.1, unspecific monooxygenase) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. It also reduces cytochrome b5 and cytochrome c. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction." +"1.6.2.5",A flavoprotein (FAD). +"1.6.3.1","Requires FAD, heme and calcium. When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen. The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups. This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalysed biosynthesis of thyroid hormones." +"1.6.5.2","A flavoprotein. The enzyme catalyses a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone [6]. The animal, but not the plant, form of the enzyme is inhibited by dicoumarol." +"1.6.5.3","A flavoprotein (FMN) containing iron-sulfur clusters. The complex is present in mitochondria and aerobic bacteria. Breakdown of the complex can release EC 1.6.99.3, NADH dehydrogenase. In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD+ to NADH." +"1.6.5.5","A zinc enzyme, specific for NADPH. Catalyses the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates [1]. Dicoumarol [cf. EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)] and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2 [1]. In some mammals, the enzyme is abundant in the lens of the eye, where it is identified with the protein zeta-crystallin." +"1.6.5.6",Involved in the 4-nitrophenol degradation pathway in bacteria. +"1.6.5.7","A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate." +"1.6.99.1","A flavoprotein (FMN in yeast, FAD in plants)." +"1.6.99.3","A flavoprotein containing iron-sulfur centres. After preparations have been subjected to certain treatments, cytochrome c may act as an acceptor. Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment. Present in a mitochondrial complex as EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating)." +"1.6.99.5","Menaquinone can act as acceptor. Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives." +"1.6.99.6","A flavoprotein. Menaquinone can act as acceptor. Inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol." +"1.7.1.1",An iron-sulfur molybdenum flavoprotein. +"1.7.1.2",An iron-sulfur molybdenum flavoprotein. +"1.7.1.3",An iron-sulfur molybdenum flavoprotein. +"1.7.1.4","An iron-sulfur flavoprotein (FAD) containing siroheme. The enzymes from the fungi Neurospora crassa [1], Emericella nidulans [2] and Candida nitratophila [4] can use either NADPH or NADH as electron donor. cf. EC 1.7.1.15, nitrite reductase (NADH)." +"1.7.1.5",A metalloprotein. +"1.7.1.6","The reaction occurs in the reverse direction to that shown above. Other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B can also be reduced [2]." +"1.7.1.10",Also acts on some hydroxamates. +"1.7.1.12","Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl." +"1.7.2.1","The reaction is catalysed by two types of enzymes, found in the perimplasm of denitrifying bacteria. One type comprises proteins containing multiple copper centres, the other a heme protein, cytochrome cd1. Acceptors include c-type cytochromes such as cytochrome c-550 or cytochrome c-551 from Paracoccus denitrificans or Pseudomonas aeruginosa, and small blue copper proteins such as azurin and pseudoazurin. Cytochrome cd1 also has oxidase and hydroxylamine reductase activities. May also catalyse the reaction of hydroxylamine reductase (EC 1.7.99.1) since this is a well-known activity of cytochrome cd1." +"1.7.2.2","Found as a multiheme cytochrome in many bacteria. The enzyme from Escherichia coli contains five hemes c and requires Ca2+. It also reduces nitric oxide and hydroxylamine to ammonia, and sulfite to sulfide." +"1.7.2.3",Contains bis(molybdopterin guanine dinucleotide)molybdenum cofactor. The reductant is a membrane-bound multiheme cytochrome c. Also reduces dimethyl sulfoxide to dimethyl sulfide. +"1.7.3.1","Has an absolute requirement for FAD [4]. While nitroethane may be the physiological substrate [2], the enzyme also acts on several other nitroalkanes, including 1-nitropropane, 2-nitropropane, 1-nitrobutane, 1-nitropentane, 1-nitrohexane, nitrocyclohexane and some nitroalkanols [4]. Differs from EC 1.13.12.16, nitronate monooxygenase, in that the preferred substrates are neutral nitroalkanes rather than anionic nitronates [4]." +"1.7.3.3","This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase)." +"1.7.3.4","The enzyme from the heterotrophic nitrifying bacterium Paracoccus denitrificans contains three to five non-heme, non-iron-sulfur iron atoms and interacts with cytochrome c556 and pseudoazurin [2,3]." +"1.7.3.5","A flavoprotein (FMN). The primary products of the enzymic reaction are probably the nitropropanoate free radical and superoxide. Also acts, more slowly, on 4-aci-nitrobutanoate." +"1.7.7.1",An iron protein. Contains siroheme and [4Fe-4S] clusters. +"1.7.7.2",A molybdenum-iron-sulfur protein. +"1.7.99.1","A flavoprotein. Reduced pyocyanine, methylene blue and flavins act as donors for the reduction of hydroxylamine. May be identical to EC 1.7.2.1, nitrite reductase (NO-forming)." +"1.7.99.4","The Pseudomonas enzyme is a cytochrome, but the enzyme from Micrococcus halodenitrificans is an iron protein containing molybdenum. Reduced benzyl viologen and other dyes bring about the reduction of nitrate." +"1.7.99.6",A copper protein. Reduced viologens or methylene blue act as donors for the reduction of nitrous oxide. +"1.7.99.7",A heterodimer of cytochromes b and c. Phenazine methosulfate can act as acceptor. +"1.7.99.8",The enzyme is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria. The conversion of hydroxylamine by the enzyme from Brocadia anammoxidans results in the formation of NO and N2O [1]. Hydroxylamine is not a substrate for the enzyme from planctomycete KSU-1 [2]. +"1.13.11.56",This enzyme is involved in naphthalene degradation. Requires Fe2+. +"1.8.1.2","Contains siroheme, [4Fe-4S] cluster, FAD and FMN. The enzyme, which catalyses the six-electron reduction of sulfite to sulfide, is involved in sulfate assimilation in bacteria and yeast. Different from EC 1.8.1.22, dissimilatory sulfite reductase system, which is involved in prokaryotic sulfur-based energy metabolism. cf. EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin)." +"1.8.1.3",A molybdohemoprotein. +"1.8.1.4","A flavoprotein (FAD). A component of the multienzyme 2-oxo-acid dehydrogenase complexes. In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes. Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system ({AminoAcid/GlyCleave} for diagram), in which it acts, together with EC 1.4.4.2, glycine dehydrogenase (decarboxylating), and EC 2.1.2.10, aminomethyltransferase, to break down glycine. It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate. This enzyme was first shown to catalyse the oxidation of NADH by methylene blue; this activity was called diaphorase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein [6]." +"1.8.1.5","Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-sulfanylethane-1-sulfonate); no CoM analogs will substitute. This enzyme forms component II of a four-component enzyme system {comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]} that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2." +"1.8.1.7",A dimeric flavoprotein (FAD); activity is dependent on a redox-active disulfide in each of the active centres. +"1.8.1.9","A flavoprotein (FAD). The enzyme restores the activity of thioredoxin by reducing an internal disulfide bridge. cf. EC 1.8.98.8, thioredoxin-disulfide reductase (factor 420-dependent)." +"1.8.1.10","A flavoprotein. The substrate is a mixed disulfide. May be identical to EC 1.8.1.9, thioredoxin-disulfide reductase." +"1.8.1.11",Also acts on lipoate. +"1.8.1.12","Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC 1.8.1.7, glutathione-disulfide reductase)" +"1.8.1.13","Contains FAD. The enzyme, which is found only in halobacteria, maintains the concentration of gamma-glutamylcysteine, the major low molecular weight thiol in halobacteria. Not identical with EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.14 (CoA-disulfide reductase)." +"1.8.1.14","A flavoprotein. Not identical with EC 1.8.1.6 (cystine reductase), EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.13 (bis-gamma-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1]." +"1.8.1.15","Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate." +"1.8.2.1","Associated with cytochrome c-551. The enzyme from the bacterium Starkeya novella contains a molybdopyranopterin cofactor and a smaller monoheme cytochrome c subunit. cf. EC 1.8.5.6, sulfite dehydrogenase (quinone)." +"1.8.2.2","The enzyme catalyses the reversible formation of a sulfur-sulfur bond between the sulfane atoms of two thiosulfate molecules, yielding tetrathionate and releasing two electrons. In many bacterial species the enzyme is a diheme c-type cytochrome. In a number of organisms, including Thiomonas intermedia and Sideroxydans lithotrophicus, a second diheme cytochrome (TsdB) acts as the electron acceptor. However, some organisms, such as Allochromatium vinosum, lack TsdB. The electron acceptor in these organisms may be the high-potential iron-sulfur protein (HiPIP)." +"1.8.3.1",A molybdohemoprotein. +"1.8.3.2","R may be =S or =O, or a variety of other groups. The enzyme is not specific for R'." +"1.8.3.3","A flavoprotein (FAD). Also acts, more slowly, on L-cysteine and several other thiols." +"1.8.3.5","A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18." +"1.8.4.1",The reactions catalysed by this enzyme and by others in this subclass may be similar to those catalysed by EC 2.5.1.18 glutathione transferase. +"1.8.4.2",Reduces insulin and some other proteins. +"1.8.4.5"," In the reverse reaction, dithiothreitol can replace reduced thioredoxin, and other methyl sulfoxides can replace methionine sulfoxide." +"1.8.4.6","Dithiothreitol, but not 2-mercaptoethanol, can replace a reduced thioredoxin in the reverse reaction. Does not act on free methionine (cf. EC 1.8.4.5 methionine-S-oxide reductase)" +"1.8.4.7",Converts EC 1.17.1.4 xanthine dehydrogenase into EC 1.17.3.2 xanthine oxidase in the presence of glutathione disulfide; also reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol reagents. +"1.8.4.8",Specific for PAPS. The enzyme from Escherichia coli will use thioredoxins from other species. +"1.8.4.9","This enzyme differs from EC 1.8.99.2, adenylyl-sulfate reductase, in using glutathione as the reductant. Glutathione can be replaced by gamma-glutamylcysteine or dithiothreitol, but not by thioredoxin, glutaredoxin or 2-sulfanylethan-1-ol (2-mercaptoethanol). The enzyme from the mouseear cress, Arabidopsis thaliana, contains a glutaredoxin-like domain. The enzyme is also found in other photosynthetic eukaryotes, e.g., the Madagascar periwinkle, Catharanthus roseus and the hollow green seaweed, Ulva intestinalis." +"1.8.4.10","Uses adenylyl sulfate, not phosphoadenylyl sulfate, distinguishing this enzyme from EC 1.8.4.8, phosphoadenylyl-sulfate reductase (thioredoxin). Uses thioredoxin as electron donor, not glutathione or other donors, distinguishing it from EC 1.8.4.9 [adenylyl-sulfate reductase (glutathione)] and EC 1.8.99.2 (adenylyl-sulfate reductase)." +"1.8.5.2","The reaction can also proceed with ferricyanide as the electron acceptor, but more slowly. Unlike EC 1.8.2.2, thiosulfate dehydrogenase, this enzyme cannot utilize cytochrome c as an acceptor." +"1.8.7.1","An iron protein. The enzyme participates in sulfate assimilation. While it is usually found in cyanobacteria, plants and algae, it has also been reported in bacteria [4]. Different from EC 1.8.1.22, dissimilatory sulfite reductase system, which is involved in prokaryotic sulfur-based energy metabolism. cf. EC 1.8.1.2, assimilatory sulfite reductase (NADPH). " +"1.8.98.1","This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase and EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase." +"1.8.98.2","In the course of the reactions of the peroxiredoxins (EC 1.11.1.24, EC 1.11.1.25, EC 1.11.1.26, EC 1.11.1.27, EC 1.11.1.28 and EC 1.11.1.29), the peroxidatic cysteine residue is alternately oxidized to the sulfenic acid, S-hydroxycysteine, and reduced back to cysteine. Occasionally the S-hydroxycysteine residue is further oxidized to the sulfinic acid S-hydroxy-S-oxocysteine, thereby inactivating the enzyme. The reductase provides a mechanism for regenerating the active form of peroxiredoxin, i.e. the peroxiredoxin-(S-hydroxycysteine) form. Apparently the reductase first catalyses the phosphorylation of the -S(O)-OH group by ATP to give -S(O)-O-P, which is attached to the peroxiredoxin by a cysteine residue, forming an -S(O)-S- link between the two enzymes. Attack by a thiol splits this bond, leaving the peroxiredoxin as the sulfenic acid and the reductase as the thiol." +"1.8.99.1",An iron-protein. A stoichiometry of six molecules of reduced methyl viologen per molecule of sulfide formed was found. +"1.8.99.2",An iron flavoprotein (FAD). Methyl viologen can act as acceptor. +"1.8.99.3",Methylviologen can act as acceptor. A group of sirohemoproteins containing iron-sulfur centres (P-582). +"1.9.3.1","An oligomeric membrane heme-Cu: O2 reductase-type enzyme that terminates the respiratory chains of aerobic and facultative aerobic organisms. The reduction of O2 to water is accompanied by the extrusion of four protons. The aa3-type enzymes of mitochondria and many bacterial species are the most abundant group, but other variations, such as the bacterial cbb3 enzymes, also exist. All of the variants have a conserved catalytic core subunit (subunit I) that contains a low spin heme (of a- or b-type), a binuclear metal center composed of a high spin heme (of a-, o-, or b-type heme, referred to as a3, o3 or b3)-iron, and a Cu atom (CuB). Besides subunit I, the enzyme usually has at least two other core subunits: subunit II is the primary electron acceptor; subunit III usually does not contain any cofactors, but in the case of cbb3-type enzymes it is a diheme c-type cytochrome. While most bacterial enzymes consist of only 3-4 subunits, the mitochondrial enzyme is much more complex and contains 14 subunits." +"1.9.99.1",An iron protein. +"1.10.1.1",Some preparations also utilize NAD+. +"1.10.2.2","The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. The mammalian enzyme contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non-cytoplasmic compartment (cf. EC 1.6.99.3, NADH dehydrogenase)." +"1.10.3.1","A type 3 copper protein that catalyses exclusively the oxidation of catechol (i.e., o-diphenol) to the corresponding o-quinone. The enzyme also acts on a variety of substituted catechols. +It is different from tyrosinase, EC 1.14.18.1, which can catalyse both the monooxygenation of monophenols and the oxidation of catechols." +"1.10.3.2","A group of multi-copper proteins of low specificity acting on both o- and p-quinols, and often acting also on aminophenols and phenylenediamine. The semiquinone may react further either enzymically or non-enzymically." +"1.10.3.3",A multicopper protein. +"1.10.3.4","A flavoprotein which catalyses a 6-electron oxidation. The enzyme from the plant Tecoma stans requires Mn2+ and FAD [1] whereas the fungus Pycnoporus coccineus requires Mn2+ and riboflavin 5'-phosphate [2], the bacteria Streptomyces antibioticus requires Cu2+ [4] and the plant Bauhenia monandra does not require any co-factors [3]." +"1.10.3.6","Acts also on benzene-1,4-diol and, more slowly, on some other p-quinols. Not identical with EC 1.10.3.1 (catechol oxidase), EC 1.10.3.2 (laccase), EC 1.10.3.4 (o-aminophenol oxidase) or EC 1.10.3.5 (3-hydroxyanthranilate oxidase)." +"1.10.99.1","A cytochrome f,b6 complex separated from chloroplasts. Also acts, more slowly, on plastoquinol-9 and ubiquinols. Cytochrome c-552 can act instead of plastocyanin, but more slowly." +"1.10.99.2","A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the oestrogens 17beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3]." +"1.10.99.3","Along with EC 1.14.13.90, zeaxanthin epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle for controlling the concentration of zeaxanthin in chloroplasts. It is activated by a low pH of the thylakoid lumen (produced by high light intensity). Zeaxanthin induces the dissipation of excitation energy in the chlorophyll of the light-harvesting protein complex of photosystem II. In higher plants the enzyme reacts with all-trans-diepoxides, such as violaxanthin, and all-trans-monoepoxides, but in the alga Mantoniella squamata, only the diepoxides are good substrates." +"1.11.1.1","A flavoprotein (FAD). Ferricyanide, quinones, etc., can replace H2O2." +"1.11.1.3",Acts on long-chain fatty acids from dodecanoic to octadecanoic acid. +"1.11.1.5",A hemoprotein. +"1.11.1.6","A hemoprotein. A manganese protein containing MnIII in the resting state, which also belongs here, is often called pseudocatalase. The enzymes from some organisms, such as Penicillium simplicissimum, can also act as a peroxidase (EC 1.11.1.7) for which several organic substances, especially ethanol, can act as a hydrogen donor. Enzymes that exhibit both catalase and peroxidase activity belong under EC 1.11.1.21, catalase-peroxidase." +"1.11.1.7","Heme proteins with histidine as proximal ligand. The iron in the resting enzyme is Fe(III). They also peroxidize non-phenolic substrates such as 3,3',5,5'-tetramethylbenzidine (TMB) and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS). Certain peroxidases (e.g. lactoperoxidase, SBP) oxidize bromide, iodide and thiocyanate." +"1.11.1.8",Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine. +"1.11.1.9","A protein containing a selenocysteine residue. Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 lipoxygenase on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase)." +"1.11.1.10","Brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds. Also oxidizes bromide and iodide. Enzymes of this type are either heme-thiolate proteins, or contain vanadate. A secreted enzyme produced by the ascomycetous fungus Caldariomyces fumago (Leptoxyphium fumago) is an example of the heme-thiolate type. It catalyses the production of hypochlorous acid by transferring one oxygen atom from H2O2 to chloride. At a separate site it catalyses the chlorination of activated aliphatic and aromatic substrates, via HClO and derived chlorine species. In the absence of halides, it shows peroxidase (e.g. phenol oxidation) and peroxygenase activities. The latter inserts oxygen from H2O2 into, for example, styrene (side chain epoxidation) and toluene (benzylic hydroxylation), however, these activities are less pronounced than its activity with halides. Has little activity with non-activated substrates such as aromatic rings, ethers or saturated alkanes. The chlorinating peroxidase produced by ascomycetous fungi (e.g. Curvularia inaequalis) is an example of a vanadium chloroperoxidase, and is related to bromide peroxidase (EC 1.11.1.18). It contains vanadate and oxidizes chloride, bromide and iodide into hypohalous acids. In the absence of halides, it peroxygenates organic sulfides and oxidizes ABTS [2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid)] but no phenols." +"1.11.1.11",A heme protein. Oxidizes ascorbate and low molecular weight aromatic substrates. The monodehydroascorbate radical produced is either directly reduced back to ascorbate by EC 1.6.5.4 [monodehydroascorbate reductase (NADH)] or undergoes non-enzymic disproportionation to ascorbate and dehydroascorbate. +"1.11.1.12","A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase)." +"1.11.1.13","A hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ [4]. The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates [1]. It is inactive with veratryl alcohol or nonphenolic substrates." +"1.11.1.14","A hemoprotein, involved in the oxidative breakdown of lignin by white-rot basidiomycete fungi. The reaction involves an initial oxidation of the heme iron by hydrogen peroxide, forming compound I (FeIV=O radical cation) at the active site. A single one-electron reduction of compound I by an electron derived from a substrate molecule yields compound II (FeIV=O non-radical cation), followed by a second one-electron transfer that returns the enzyme to the ferric oxidation state. The electron transfer events convert the substrate molecule into a transient cation radical intermediate that fragments spontaneously. The enzyme can act on a wide range of aromatic compounds, including methoxybenzenes and nonphenolic beta-O-4 linked arylglycerol beta-aryl ethers, but cannot act directly on the lignin molecule, which is too large to fit into the active site. However larger lignin molecules can be degraded in the presence of veratryl alcohol. It has been suggested that the free radical that is formed when the enzyme acts on veratryl alcohol can diffuse into the lignified cell wall, where it oxidizes lignin and other organic substrates. In the presence of high concentration of hydrogen peroxide and lack of substrate, the enzyme forms a catalytically inactive form (compound III). This form can be rescued by interaction with two molecules of the free radical products. In the case of veratryl alcohol, such an interaction yields two molecules of veratryl aldehyde." +"1.11.1.15","Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see mechanism). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants (R'-SH) (e.g. thioredoxin, AhpF, tryparedoxin or AhpD), completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond [1]. To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor [3]. The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule [4]." +"1.11.1.24","Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [4]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Thioredoxin-dependent peroxiredoxins are the most common. They have been reported from archaea, bacteria, fungi, plants, and animals." +"1.12.1.2",An iron-sulfur flavoprotein (FMN or FAD). Some forms of this enzyme contain nickel. +"1.12.1.3","The protein from the bacterium Desulfovibrio fructosovorans is an iron-sulfur protein that exclusively functions as a hydrogen dehydrogenase [1], while the enzyme from the archaeon Pyrococcus furiosus is a nickel, iron, iron-sulfur protein, that is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.5, hydrogen dehydrogenase [NAD(P)+]. " +"1.12.2.1","An iron-sulfur protein. Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). Methylene blue and other acceptors can also be reduced." +"1.12.5.1","Contains nickel, iron-sulfur clusters and cytochrome b. Also catalyses the reduction of water-soluble quinones (e.g. 2,3-dimethylnaphthoquinone) or viologen dyes (benzyl viologen or methyl viologen)." +"1.12.7.2",Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances. +"1.12.98.1","An iron-sulfur flavoprotein (FAD) containing nickel. The enzyme from some sources contains selenocysteine. The enzyme also reduces the riboflavin analogue of F420, flavins and methyl viologen, but to a lesser extent. The hydrogen acceptor coenzyme F420 is a deazaflavin derivative." +"2.1.1.167","Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2'-O-Methylguanosine2922 is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine2921 [1]. " +"1.12.98.2",Does not catalyse the reduction of artificial dyes. Does not by itself catalyse a H2/H+ exchange reaction. Does not contain nickel or iron-sulfur clusters. +"1.12.98.3","Contains nickel, iron-sulfur clusters and cytochrome b. The enzyme from some sources contains selenocysteine." +"1.12.99.6",Uses molecular hydrogen for the reduction of a variety of substances. Contains iron-sulfur clusters. The enzyme from some sources contains nickel. +"1.13.11.1",Requires Fe3+. Involved in the metabolism of nitro-aromatic compounds by a strain of Pseudomonas putida. +"1.13.11.2",Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation. +"1.13.11.75",Contains an Fe2+-4His arrangement. The enzyme is involved in retinal biosynthesis in bacteria [2]. +"1.13.11.3","Requires Fe3+. The enzyme, which participates in the degradation of aromatic compounds, catalyses the intradiol addition of both oxygen atoms from molecular oxygen, resulting in ortho-cleavage of the aromatic ring. The type of cleavage leads to mineralization via the intermediate 3-oxoadipate." +"1.13.11.4",Requires Fe2+. +"1.13.11.5",Requires Fe2+. +"1.13.11.6",Requires Fe2+. +"1.13.11.8",Requires Fe2+. +"1.13.11.9",Requires Fe2+. +"1.13.11.10",Requires Fe2+. +"1.13.11.11","A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism [5]. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan [2]. " +"1.13.11.12","Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C-13 position with (S)-configuration. This enzyme produces precursors for several important compounds, including the plant hormone jasmonic acid. EC 1.13.11.58, linoleate 9S-lipoxygenase, catalyses a similar reaction at the second available position of these fatty acids." +"1.13.11.13",Requires iron(II). +"1.13.11.15",An iron protein. +"1.13.11.16",An iron protein. This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. +"1.13.11.17","Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (2,1-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product." +"1.13.11.18","An iron protein. Perthiols, formed spontaneously by interactions between thiols and elemental sulfur or sulfide, are the only acceptable substrate to the enzyme. The sulfite that is formed by the enzyme can be further converted into sulfate, thiosulfate or S-sulfoglutathione (GSSO3-) non-enzymically [2]." +"1.13.11.19","A non-heme iron protein that is involved in the biosynthesis of taurine. 3-Aminopropanethiol (homocysteamine) and 2-sulfanylethan-1-ol (2-mercaptoethanol) can also act as substrates, but glutathione, cysteine, and cysteine ethyl- and methyl esters are not good substrates [1,3]." +"1.13.11.20",Requires Fe2+ and NAD(P)H. +"1.13.11.24","The enzyme from Aspergillus sp. is a copper protein whereas that from Bacillus subtilis contains iron. Quercetin is a flavonol (5,7,3',4'-tetrahydroxyflavonol)." +"1.13.11.25",Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol. +"1.13.11.26",Also acts on tryptophan. +"1.13.11.27",The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the enzymes from other sources may contain essential iron or copper. +"1.13.11.28","Also acts, more slowly, with 2,3-dihydroxy-4-methylbenzoate and 2,3-dihydroxy-4-isopropylbenzoate." +"1.13.11.29","The intermediate product undergoes ring closure and oxidation, with NAD(P)+ as acceptor, to stizolobic acid. The enzyme requires Zn2+." +"1.13.11.30","The intermediate product undergoes ring closure and oxidation, with NAD(P)+ as acceptor, to stizolobinic acid. The enzyme requires Zn2+." +"1.13.11.31",The product is rapidly reduced to the corresponding 12S-hydroxy compound. +"1.13.11.32","While the enzyme from the fungus Neurospora crassa contains non-covalently bound FMN as the cofactor, that from the yeast Williopsis mrakii contains FAD [2]. This enzyme differs from EC 1.7.3.1, nitroalkane oxidase, in that the preferred substrates are anionic nitronates rather than neutral nitroalkanes [2,3]. The enzyme has broad substrate specificity that is independent of substrate size [2,3]. Some other nitroalkanes, including nitroethane, 1-nitropropane and 3-nitropentan-2-ol, can act as donors, but more slowly." +"1.13.11.33",The product is rapidly reduced to the corresponding 15S-hydroxy compound. +"1.13.11.36","An iron protein, requiring additional Fe2+. Not identical with EC 1.13.11.1 (catechol 1,2-dioxygenase), EC 1.13.11.2 (catechol 2,3-dioxygenase) or EC 1.13.11.5 (homogentisate 1,2-dioxygenase). Involved in the breakdown of the herbicide chloridazon." +"1.13.11.37",An iron protein. Highly specific; catechol and pyrogallol are acted on at less than 1% of the rate at which hydroxyquinol is oxidized. +"1.13.11.38","Requires Fe2+. Involved, with EC 4.1.2.34 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase, in the metabolism of phenanthrene in bacteria." +"1.13.11.39","Contains Fe2+ or Mn2+ [3]. This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls), and catalyses the first ring cleavage step by incorporating two oxygen atoms into the catechol ring formed by EC 1.3.1.56, cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase.The enzyme from the bacterium Burkholderia xenovorans LB400 can also process catechol, 3-methylcatechol, and 4-methylcatechol, but less efficiently [1]. The enzyme from the carbazole-degrader Pseudomonas resinovorans strain CA10 also accepts 2'-aminobiphenyl-2,3-diol [5]. The enzyme from Ralstonia sp. SBUG 290 can also accept 1,2-dihydroxydibenzofuran and 1,2-dihydroxynaphthalene [4]. The enzyme is strongly inhibited by the substrate [1].Not identical with EC 1.13.11.2 catechol 2,3-dioxygenase." +"1.13.11.40",From the coral Pseudoplexaura porosa. +"1.13.11.42","Acts on many substituted and unsubstituted indoleamines, including melatonin. Involved in the degradation of melatonin." +"1.13.11.43",An iron protein. The enzyme catalyses oxidative cleavage of the interphenyl double bond in the synthetic substrate and lignin-derived stilbenes. It is responsible for the degradation of a diarylpropane-type structure in lignin. +"1.13.11.44","Oleate and linolenate are also substrates, whereas stearate, elaidate, gamma-linolenate, arachidonate and icosapentaenate are not. This enzyme differs from lipoxygenase (EC 1.13.11.12) because it catalyses the formation of a hydroperoxide without affecting the double bonds of the substrate." +"1.13.11.45","The product (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate, is converted, more slowly, into (9Z,11E)-(13R)-13-hydroperoxyoctadeca-9,11-dienoate. The enzyme from the fungus Gaeumannomyces graminis requires Mn2+. It also acts on alpha-linolenate, whereas gamma-linolenate is a poor substrate. Oleate and arachidonate are not substrates." +"1.13.11.46",Requires Fe2+. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics. +"1.13.11.47","Does not contain a metal centre or organic cofactor. Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. The enzyme from Pseudomonas putida is highly specific for this substrate." +"1.13.11.48","Does not contain a metal centre or organic cofactor. Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with concomitant release of carbon monoxide. The enzyme from Arthrobacter sp. can also act on 3-hydroxy-4-oxoquinoline, forming N-formylanthranilate and CO (cf. EC 1.13.11.47, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase), but more slowly." +"1.13.11.49","Reaction occurs in the reverse direction in chlorate- and perchlorate-reducing bacteria. There is no activity when chlorite is replaced by hydrogen peroxide, perchlorate, chlorate or nitrite. The term 'chlorite dismutase' is misleading as the reaction does not involve dismutation/disproportionation. Contains iron and protoheme IX." +"1.13.11.50","An iron(II)-dependent enzyme. Forms the first step in the acetylacetone degradation pathway of Acinetobacter johnsonii. While acetylacetone is by far the best substrate, heptane-3,5-dione, octane-2,4-dione, 2-acetylcyclohexanone and ethyl acetoacetate can also act as substrates." +"1.13.11.51","Requires iron(II). Acts on 9-cis-violaxanthin and 9'-cis-neoxanthin but not on the all-trans isomers [2,3]. In vitro, it will cleave 9-cis-zeaxanthin. Catalyses the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress. The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.14.14.137 [(+)-abscisic acid 8'-hydroxylase]." +"1.13.12.1",A flavoprotein. Also acts on canavanine and homoarginine. +"1.13.12.2",A flavoprotein (FAD). Also acts on other diamino acids. +"1.13.12.3","The enzyme, studied from phytopathogenic bacteria such as Pseudomonas savastanoi, is involved in a pathway for the production of (indol-3-yl)acetate (IAA), the main auxin hormone in plants." +"1.13.12.4",A flavoprotein (FMN). +"1.13.12.5","This enzyme has been studied from the soft coral Renilla reniformis. Before the reaction occurs the substrate is sequestered by a coelenterazine-binding protein. Elevation in the concentration of calcium ions releases the substrate, which then interacts with the luciferase. Upon binding the substrate, the enzyme catalyses an oxygenation, producing a very short-lived hydroperoxide that cyclizes into a dioxetanone structure, which collapses, releasing a CO2 molecule. The spontaneous breakdown of the dioxetanone releases the energy (about 50 kcal/mole) that is necessary to generate the excited state of the coelenteramide product, which is the singlet form of the monoanion. In vivo the product undergoes the process of nonradiative energy transfer to an accessory protein, a green fluorescent protein (GFP), which results in green bioluminescence. In vitro, in the absence of GFP, the product emits blue light." +"1.13.12.6","Cypridina is a bioluminescent crustacea. The luciferins (and presumably the luciferases, since they cross-react) of some luminous fish (e.g. Apogon, Parapriacanthus, Porichthys) are apparently similar. The enzyme may be assayed by measurement of light emission." +"1.13.12.7","The enzyme, which is found in fireflies (Lampyridae), is responsible for their biolouminescence. The reaction begins with the formation of an acid anhydride between the carboxylic group of D-firefly luciferin and AMP, with the release of diphosphate. An oxygenation follows, with release of the AMP group and formation of a very short-lived peroxide that cyclizes into a dioxetanone structure, which collapses, releasing a CO2 molecule. The spontaneous breakdown of the dioxetanone (rather than the hydrolysis of the adenylate) releases the energy (about 50 kcal/mole) that is necessary to generate the excited state of oxyluciferin. The excited luciferin then emits a photon, returning to its ground state. The enzyme has a secondary acyl-CoA ligase activity when acting on L-firefly luciferin (see EC 6.2.1.52)." +"1.13.12.8",The enzyme from the luminous squid Watasenia may be assayed by measurement of light emission. +"1.13.12.9","The reaction shown above is about 80% of the reaction catalysed; the remaining 20% is:     L-phenylalanine + O2 + H2O = 3-phenylpyruvic acid + ammonia + H2O2 a reaction similar to that of EC 1.4.3.2, L-amino-acid oxidase." +"1.13.12.11",A flavoprotein. +"1.13.12.12","A thiol-dependent enzyme. Unlike EC 1.14.99.36, beta-carotene-15,15'-monooxygenase, it is not active towards beta-carotene. Presumably, 2-methyl-6-oxohepta-2,4-dienal is also formed in this reaction." +"1.13.12.13","The luciferase from the deep sea shrimp Oplophorus gracilirostris is a complex composed of more than one protein. The enzyme's specificity is quite broad, with both coelenterazine and bisdeoxycoelenterazine being good substrates." +"1.13.99.1",An iron protein. +"1.13.99.3","A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan." +"1.14.11.1",Requires Fe2+ and ascorbate. +"1.14.11.2","Requires Fe2+ and ascorbate.The enzyme, which is located within the lumen of the endoplasmic reticulum, catalyses the 4-hydroxylation of prolines in -X-Pro-Gly- sequences. The 4-hydroxyproline residues are essential for the formation of the collagen triple helix. The enzyme forms a complex with protein disulfide isomerase and acts not only on procollagen but also on more than 15 other proteins that have collagen-like domains." +"1.14.11.3","Requires iron(II) and ascorbate. Also acts on thymidine. cf. EC 1.14.11.10, pyrimidine-deoxynucleoside 1'-dioxygenase." +"1.14.11.4",Requires Fe2+ and ascorbate. +"1.14.11.6",Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil to oxidize its -CH2OH group first to -CHO and then to -COOH. +"1.14.11.7","Requires Fe2+ and ascorbate. The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum. It modifies proline residues within the procollagen peptide of certain collagen types. The modification is essential for proper collagen triple helix formation. " +"1.14.11.8",Requires Fe2+ and ascorbate. +"1.14.11.9","Requires Fe2+ and ascorbate. This plant enzyme catalyses an early step in the flavonoid biosynthesis pathway, leading to the production of flavanols and anthocyanins. Substrates include (2S)-naringenin, (2S)-eriodictyol, (2S)-dihydrotricetin and (2S)-pinocembrin. Some enzymes are bifuctional and also catalyse EC 1.14.20.6, flavonol synthase." +"1.14.11.10","Requires iron(II) and ascorbate. cf. EC 1.14.11.3, pyrimidine-deoxynucleoside 2'-dioxygenase." +"1.14.11.11",Requires Fe2+ and ascorbate. +"1.14.11.12",Requires Fe2+. +"1.14.11.13",Also acts on a number of other gibberellins. +"1.14.11.14",Requires Fe2+ and ascorbate. +"1.14.11.15",Requires Fe2+ and ascorbate. +"1.14.11.16","Requires Fe2+. Some vitamin K-dependent coagulation factors, as well as synthetic peptides based on the structure of the first epidermal growth factor domain of human coagulation factor IX or X, can act as acceptors." +"1.14.11.17","Requires FeII. The enzyme from Escherichia coli also acts on pentanesulfonate, 3-(N-morpholino)propanesulfonate and 2-(1,3-dioxoisoindolin-2-yl)ethanesulfonate, but at lower rates." +"1.14.11.18",Part of the peroxisomal phytanic acid alpha-oxidation pathway. Requires Fe2+ and ascorbate. +"1.14.11.19","The enzyme requires Fe(II) and ascorbate. It is involved in the pathway by which many flowering plants make anthocyanin flower pigments (glycosylated anthocyandins). The enzyme hydroxylates the C-3 carbon, followed by a trans diaxial elimination, forming a C-2,C-3 enol. The product loses a second water molecule to form anthocyanidins. When assayed in vitro, non-enzymic epimerization of the product can lead to formation of dihydroflavanols. Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin and (+)-epitaxifolin are formed. The enzyme can also oxidize the formed (+)-taxifolin to quercetin (cf. EC 1.14.11.23, flavonol synthase) [2,3]." +"1.14.11.20","Requires Fe2+ and ascorbate. Also acts on 3-hydroxy-16-methoxy-2,3-dihydrotabersonine and to a lesser extent on 16-methoxy-2,3-dihydrotabersonine." +"1.14.11.21","Contains nonheme iron. Catalyses three separate oxidative reactions in the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site." +"1.14.11.22",Requires ascorbate for full activity and Fe2+. +"1.14.11.23","In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from the satsuma Citrus unshiu also has a non-specific activity that trans-hydroxylates the flavanones (2S)-naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively [2]. Requires Fe2+." +"1.14.11.24",Requires iron(II). It is also likely that this enzyme can catalyse the hydroxylation of 3-epihydroxy-2'-deoxymugineic acid to form 3-epihydroxymugineic acid. +"1.14.11.25",Requires iron(II). +"1.14.11.26","Requires iron(II). The enzyme can also use 3-exomethylenecephalosporin C as a substrate to form deacetoxycephalosporin C, although more slowly [2]. In Acremonium chrysogenum, the enzyme forms part of a bifunctional protein along with EC 1.14.20.1, deactoxycephalosporin-C synthase. It is a separate enzyme in Streptomyces clavuligerus. " +"1.14.12.1",Requires Fe2+. +"1.14.12.3","A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin. Requires Fe2+." +"1.14.12.4",A flavoprotein (FAD). +"1.14.12.5",A flavoprotein. +"1.14.12.7","A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+." +"1.14.12.8","A system, containing a reductase which is an iron-sulfur flavoprotein (FMN), an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+." +"1.14.12.9","A system, containing a reductase and an iron-sulfur oxygenase, and no independent ferredoxin. Requires Fe2+. Also acts on 4-bromophenyl acetate." +"1.14.12.10","A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), and an iron-sulfur oxygenase. Requires Fe2+." +"1.14.12.11","A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase, and a ferredoxin. Some other aromatic compounds, including ethylbenzene, 4-xylene and some halogenated toluenes, are converted into the corresponding cis-dihydrodiols." +"1.14.12.12","This enzyme is a member of the ring-hydroxylating dioxygenase (RHD) family of bacterial enzymes that play a critical role in the degradation of aromatic compounds, such as polycyclic aromatic hydrocarbons [5]. This enzyme comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.3, ferredoxin---NAD+ reductase), an iron-sulfur oxygenase, and ferredoxin. Requires Fe2+." +"1.14.12.13","A multicomponent enzyme system composed of a dioxygenase component and an electron transfer component. The latter contains FAD. The enzyme, characterized from the bacterium Burkholderia cepacia 2CBS, has a broad substrate specificity. Substrates include 2-fluorobenzoate, 2-chlorobenzoate, 2-bromobenzoate, and 2-iodobenzoate, which are processed in this order of preference." +"1.14.12.15",Has been shown to contain a Rieske [2Fe-2S] cluster +"1.14.12.16","3-Methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also substrates. Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers" +"1.14.12.17",A flavohemoglobin (FAD). It has been proposed that FAD functions as the electron carrier from NADPH to the ferric heme cofactor +"1.14.12.18","Requires Fe2+. The enzyme from Burkholderia fungorum LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske-type iron-sulfur cluster and a catalytic mononuclear nonheme iron centre. Chlorine-substituted biphenyls can also act as substrates. Similar to the three-component enzyme systems EC 1.14.12.3 (benzene 1,2-dioxygenase) and EC 1.14.12.11 (toluene dioxygenase)." +"1.14.12.19",This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. It catalyses the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3-phenylprop-2-enoate. +"1.14.13.1",A flavoprotein (FAD). +"1.14.13.2",A flavoprotein (FAD). Most enzymes from Pseudomonas are highly specific for NADPH (cf. EC 1.14.13.33 4-hydroxybenzoate 3-monooxygenase [NAD(P)H]). +"1.14.13.3",A flavoprotein. +"1.14.13.4",A flavoprotein (FAD). +"1.14.13.5",A flavoprotein (FAD). +"1.14.13.6",A flavoprotein (FAD). +"1.14.13.7","A flavoprotein (FAD). The enzyme from the fungus Trichosporon cutaneum has a broad substrate specificity, and has been reported to catalyse the hydroxylation of a variety of substituted phenols, such as fluoro-, chloro-, amino- and methyl-phenols and also dihydroxybenzenes. cf. EC 1.14.14.20, phenol 2-monooxygenase (FADH2)." +"1.14.13.8","A flavoprotein. A broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines [3,4]. This enzyme is distinct from other monooxygenases in that the enzyme forms a relatively stable hydroperoxy flavin intermediate [4,5]. This microsomal enzyme generally converts nucleophilic heteroatom-containing chemicals and drugs into harmless, readily excreted metabolites. For example, N-oxygenation is largely responsible for the detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [2,6]" +"1.14.13.9",A flavoprotein (FAD). +"1.14.13.10",A flavoprotein. +"1.14.13.11","NADH also acts, more slowly. Involves a heme-thiolate protein (P-450)." +"1.14.13.12",Requires Fe2+ and tetrahydropteridine. +"1.14.13.15","The enzyme requires ferredoxin and ferredoxin reductase. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-en-3beta,7alpha-diol, 7alpha-hydroxycholest-4-en-3-one, and 5beta-cholestane-3alpha,7alpha-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25." +"1.14.13.17",A heme-thiolate protein (P-450). +"1.14.13.18",A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming 2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming hydroquinone and glycolate). +"1.14.13.19","A flavoprotein, converting a flavanol into a flavanone. Also acts on fustin, but not on catechin, quercetin or mollisacidin." +"1.14.13.20","A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but more slowly." +"1.14.13.21","Acts on a number of flavonoids, including naringenin and dihydrokaempferol. Does not act on 4-coumarate or 4-coumaroyl-CoA." +"1.14.13.22","A flavoprotein (FAD). In the catalytic mechanism of this enzyme, the nucleophilic species that attacks the carbonyl group is a peroxyflavin intermediate that is generated by reaction of the enzyme-bound flavin cofactor with NAD(P)H and oxygen [2]. This enzyme is able to catalyse a wide range of oxidative reactions, including enantioselective Baeyer-Villiger reactions [3], sulfoxidations [4], amine oxidations [5] and epoxidations [6]." +"1.14.13.23","A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions." +"1.14.13.24","A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions; NADPH can act instead of NADH, but more slowly." +"1.14.13.25","The enzyme is soluble, in contrast to the particulate enzyme, EC 1.14.18.3. Broad specificity; many alkanes can be hydroxylated, and alkenes are converted into the corresponding epoxides; CO is oxidized to CO2, ammonia is oxidized to hydroxylamine, and some aromatic compounds and cyclic alkanes can also be hydroxylated, but more slowly." +"1.14.13.27",A flavoprotein (FAD). Acts on anthranilate and 4-aminosalicylate but not on salicylate (cf. EC 1.14.13.1 salicylate 1-monooxygenase). +"1.14.13.28",Possibly a heme-thiolate protein (P-450). The product of the reaction is the biosynthetic precursor of the phytoalexin glyceollin in soybean. +"1.14.13.29",A flavoprotein (FAD). +"1.14.13.30","A heme-thiolate protein (P-450). Not identical with EC 1.14.13.34, leukotriene-E4 20-monooxygenase." +"1.14.13.31",Involved in the metabolism of nitro-aromatic compounds by a strain of Pseudomonas putida. +"1.14.13.32","A microsomal flavin-containing monooxygenase. A similar conversion is also carried out by some microsomal cytochrome P-450 enzymes [EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming)]. It is estimated that cytochrome P-450s are responsible for 70% of the activity." +"1.14.13.33","A flavoprotein (FAD). The enzyme from Corynebacterium cyclohexanicum is highly specific for 4-hydroxybenzoate, but uses NADH and NADPH at approximately equal rates (cf. EC 1.14.13.2 4-hydroxybenzoate 3-monooxygenase). It is less specific for NADPH than EC 1.14.13.2." +"1.14.13.34","Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.14.94, leukotriene-B4 20-monooxygenase." +"1.14.13.35",The enzyme from Aspergillus niger is an iron protein; that from the yeast Trichosporon cutaneum is a flavoprotein (FAD). +"1.14.13.36",Also acts on trans-5-O-(4-coumaroyl)shikimate. +"1.14.13.37",A heme-thiolate protein (P-450). +"1.14.13.38","The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. It can also catalyse EC 1.14.13.234, 12-dehydrotetracycline 5-monooxygenase." +"1.14.13.39","The enzyme consists of linked oxygenase and reductase domains. The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin, and its two domains are linked via a regulatory calmodulin-binding domain. Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. The reductase domain of the enzyme from the bacterium Sorangium cellulosum utilizes a [2Fe-2S] cluster to transfer the electrons from NADPH to the active center. cf. EC 1.14.14.47, nitric-oxide synthase (flavodoxin)." +"1.14.13.40","A flavoprotein (FAD). The non-aromatic product is unstable and releases CO2 and NH3, forming 1,4-cyclohexanedione." +"1.14.13.41","A P-450 (heme-thiolate) protein. This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase and EC 2.4.1.85, cyanohydrin beta-glucosyltransferase. Some 2-(4-hydroxyphenyl)-1-nitroethane is formed as a side product." +"1.14.13.42",A heme-thiolate protein (P-450). +"1.14.13.43",The enzyme cleaves the anthraquinone ring of questin to form a benzophenone. Involved in the biosynthesis of the seco-anthraquinone (+)-geodin. +"1.14.13.44","Also converts 2,2'-dihydroxybiphenyl into 2,2',3-trihydroxy-biphenyl." +"1.14.13.47","High specificity, but NADH can act instead of NADPH, although more slowly. A heme-thiolate protein (P-450)." +"1.14.13.48","High specificity, but NADH can act instead of NADPH, but more slowly. A heme-thiolate protein (P-450)." +"1.14.13.49","High specificity, but NADH can act instead of NADPH, although more slowly. A heme-thiolate protein (P-450)." +"1.14.13.50","A flavoprotein (FAD). The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position [2]. If C-4 carries a halogen substituent, reaction 1 is catalysed; if C-4 is unsubstituted, reaction 2 is catalysed." +"1.14.13.51","The product undergoes non-enzymic cleavage and subsequent ring closure to form the lactone 4,5-dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one." +"1.14.13.52",A heme-thiolate protein (P-450). Also acts on biochanin A and other isoflavones with a 4'-methoxy group. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. +"1.14.13.53","A heme-thiolate protein (P-450). Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.13.89, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones." +"1.14.13.54","A single FAD-containing enzyme catalyses three types of monooxygenase (Baeyer-Villiger oxidation) reaction. The oxidative esterification of a number of derivatives of progesterone to produce the corresponding 17alpha-hydroxysteroid 17-acetate ester, such as testosterone acetate, is shown in Reaction (1). The oxidative lactonization of a number of derivatives of androstenedione to produce the 13,17-secoandrosteno-17,13alpha-lactone, such as testololactone, is shown in Reaction (2). The oxidative cleavage of the 17beta-side-chain of 17alpha-hydroxyprogesterone to produce androstenedione and acetate is shown in Reaction (3). Reaction (1) is also catalysed by EC 1.14.99.4 (progesterone monooxygenase), and Reactions (2) and (3) correspond to that catalysed by EC 1.14.99.12 (androst-4-ene-3,17-dione monooxygenase). The possibility that a single enzyme is responsible for the reactions ascribed to EC 1.14.99.4 and EC 1.14.99.12 in other tissues cannot be excluded." +"1.14.13.55",A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants. +"1.14.13.56",A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants. +"1.14.13.57",A heme-thiolate protein (P-450) +"1.14.13.58",The enzyme from the denitrifying bacterium Pseudomonas KB740 catalyses a flavin-requiring reaction (FAD or FMN). Benzoate is not a substrate. +"1.14.13.59","A flavoprotein (FAD). The enzyme from strain EN 222 of Escherichia coli is highly specific for L-lysine; L-ornithine and L-homolysine are, for example, not substrates." +"1.14.13.60",A heme-thiolate protein (P-450). The enzyme from mammalian liver differs from cholesterol 7alpha-monooxygenase (EC 1.14.13.17) in having no activity towards cholesterol. +"1.14.13.61",Requires iron. Quinolin-2-ol exists largely as the quinolin-2(1H)-one tautomer. +"1.14.13.62",Quinolin-4-ol exists largely as the quinolin-4(1H)-one tautomer. +"1.14.13.63","3-hydroxyphenylacetate 6-hydroxylase from Flavobacterium sp. is highly specific for 3-hydroxyphenylacetate and uses NADH and NADPH as electron donors with similar efficiency." +"1.14.13.64",Requires FAD. The enzyme from Candida parapsilosis is specific for 4-hydroxybenzoate derivatives and prefers NADH to NADPH as electron donor. +"1.14.13.65","3-Methyl-quinolin-2-ol is also a substrate. Quinolin-2-ols exist largely as the quinolin-2(1H)-one tautomers." +"1.14.13.66",The product decomposes spontaneously to 6-oxohexanoic acid (adipic semialdehyde). +"1.14.13.68","This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.41, tyrosine N-monooxygenase and EC 2.4.1.85, cyanohydrin beta-glucosyltransferase." +"1.14.13.69","This bacterial binuclear non-heme iron enzyme is a multicomponent enzyme complex comprising an oxygenase, a reductase, and a Rieske-type ferredoxin. The enzyme from the bacterium Xanthobacter sp. strain Py2 contains an additional small protein of unknown function that is essential for activity. In general, the enzyme oxygenates C2 to C6 aliphatic alkenes, although enzymes from different organisms show different substrate range. With propene as substrate, the stereospecificity of the epoxypropane formed is 95% (R) and 5% (S)." +"1.14.13.70","This heme-thiolate (P-450) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses two successive hydroxylations of the 14alpha-methyl group, followed by elimination as formate, leaving a 14(15) double bond." +"1.14.13.71",A heme-thiolate protein (P-450) involved in benzylisoquinoline alkaloid synthesis in higher plants. +"1.14.13.72",Requires cytochrome b5. Also acts on 4alpha-methyl-5alpha-cholest-7-en-3beta-ol. The sterol can be based on cycloartenol as well as lanosterol. +"1.14.13.73",A heme-thiolate protein (P-450). +"1.14.13.74",A heme-thiolate protein (P-450). +"1.14.13.75",A heme-thiolate protein (P-450). Forms a stage in the biosynthesis of the indole alkaloid ajmaline. +"1.14.13.76",This microsomal cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel). +"1.14.13.77",This cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel). +"1.14.13.78",Requires cytochrome P-450. Catalyses three sucessive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid. +"1.14.13.79","Requires cytochrome P-450. Catalyses three sucessive oxidations of ent-kaurenoic acid. The second step includes a ring-B contraction giving the gibbane skeleton. In pumpkin (Cucurbita maxima) ent-6alpha,7alpha-dihydroxykaur-16-en-19-oate is also formed." +"1.14.13.80","The reaction is stereospecific with over 95% yield of (+)-trans-carveol from (R)-limonene. (S)-Limonene, the substrate for EC 1.14.13.48, (S)-limonene 6-monooxygenase, is not a substrate. Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds." +"1.14.13.81","Requires iron(II) for activity. The enzyme participates in the biosynthesis of chlorophyllide a in aerobic organisms. The same transformation is achieved in anaerobic organisms by EC 1.21.98.3, anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase. Some facultative phototrophic bacteria, such as Rubrivivax gelatinosus, possess both enzymes." +"1.14.13.82",Forms part of the vanillin degradation pathway in Arthrobacter sp. +"1.14.13.83","An iron-sulfur protein. An oxygen atom from dioxygen is incorporated into the macrocycle at C-20. In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5 and precorrin-6A, respectively." +"1.14.13.84","Contains FAD. The enzyme from Pseudomonas fluorescens ACB catalyses the conversion of a wide range of acetophenone derivatives. Highest activity occurs with compounds bearing an electron-donating substituent at the para position of the aromatic ring [1]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1)." +"1.14.13.85","A heme-thiolate protein (P-450). Glyceollins II and III are formed from 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan whereas glyceollin I is formed from the 4-isomer." +"1.14.13.86","A heme-thiolate protein (P-450). EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on 2-hydroxy-2,3-dihydrogenistein with loss of water and formation of genistein. This may occur spontaneously." +"1.14.13.87","A heme-thiolate protein (P-450). It probably forms 2-hydroxyliquiritigenin which spontaneously forms licodione. NADH can act instead of NADPH, but more slowly." +"1.14.13.88","A heme-thiolate protein (P-450). The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin. NADH is not a good substitute for NADPH." +"1.14.13.89","A heme-thiolate protein (P-450). Acts on daidzein, formononetin and genistein. EC 1.14.13.53, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone." +"1.14.13.90","A flavoprotein (FAD) that is active under conditions of low light. Along with EC 1.10.99.3, violaxanthin de-epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle, which is involved in protecting the plant against damage by excess light. It will also epoxidize lutein in some higher-plant species." +"1.14.13.91",A heme-thiolate protein (P-450). +"1.14.13.92","A flavoprotein (FAD). NADH cannot replace NADPH as coenzyme. In addition to phenylacetone, which is the best substrate found to date, this Baeyer-Villiger monooxygenase can oxidize other aromatic ketones [1-(4-hydroxyphenyl)propan-2-one, 1-(4-hydroxyphenyl)propan-2-one and 3-phenylbutan-2-one], some alipatic ketones (e.g. dodecan-2-one) and sulfides (e.g. 1-methyl-4-(methylsulfanyl)benzene)." +"1.14.13.93","A heme-thiolate protein (P-450). Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone [1]. CO inhibits the reaction, but its effects can be reversed by the presence of blue light [1]. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously. Other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase)." +"1.14.13.94",A heme-thiolate protein (P-450). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters [1]. +"1.14.13.95","A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH---hemoprotein reductase, which reduced cytochrome b5 at the expense of NADPH. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid [2]." +"1.14.13.96","A heme-thiolate protein (P-450). This is the key enzyme in the biosynthesis of the bile acid cholic acid (3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid [3]. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent [1]." +"1.14.13.97","A heme-thiolate protein (P-450). Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid [5]." +"1.14.13.98","A heme-thiolate protein (P-450). The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood---brain barrier whereas cholesterol cannot [3]." +"1.14.13.99","A heme-thiolate protein (P-450) that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24R)-cholest-5-ene-3beta,24-diol as substrate." +"1.14.13.100","A heme-thiolate protein (P-450). Unlike EC 1.14.13.99, 24-hydroxycholesterol 7alpha-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent [2]. " +"1.14.14.1","A group of P-450 heme-thiolate proteins, acting on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. Together with EC 1.6.2.4, NADPH---hemoprotein reductase, it forms a system in which two reducing equivalents are supplied by NADPH. Some of the reactions attributed to EC 1.14.15.3, alkane 1-monooxygenase, belong here." +"1.14.14.3","The reaction sequence starts with the incorporation of a molecule of oxygen into reduced FMN bound to the enzyme, forming luciferase peroxyflavin. The peroxyflavin interacts with an aliphatic long-chain aldehyde, producing a highly fluorescent species believed to be luciferase hydroxyflavin. The enzyme is highly specific for reduced FMN and for long-chain aliphatic aldehydes with eight carbons or more. The highest efficiency is achieved with tetradecanal. cf. EC 1.13.12.18, dinoflagellate luciferase." +"1.14.14.5","The enzyme from Escherichia coli catalyses the desulfonation of a wide range of aliphatic sulfonates (unsubstituted C1- to C14-sulfonates as well as substituted C2-sulfonates). Does not desulfonate taurine (2-aminoethanesulfonate) or aromatic sulfonates. Does not use FMN as a bound cofactor. Instead, it uses reduced FMN (i.e., FMNH2) as a substrate. FMNH2 is provided by SsuE, the associated FMN reductase (EC 1.5.1.38)." +"1.14.15.1","A heme-thiolate protein (P-450). Also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide." +"1.14.15.2","A flavoprotein which requires Fe2+. Isolated from Pseudomonas putida. The product is spontaneously converted to [(1R)-5-oxo-2,2,3-trimethylcyclopent-3-enyl]acetate. The enzyme slowly oxidized (-)-camphor." +"1.14.15.3",Some enzymes in this group are heme-thiolate proteins (P-450). Also hydroxylates fatty acids in the omega-position. +"1.14.15.4","A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone." +"1.14.15.6","A heme-thiolate protein (cytochrome P-450). The reaction proceeds in three stages, with two hydroxylations at C-22 and C-20 preceding scission of the side-chain between carbons 20 and 22. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase." +"1.14.15.7","The spinach enzyme, which is located in the chloroplast, contains a Rieske-type [2Fe-2S] cluster, and probably also a mononuclear Fe centre. Requires Mg2+. Catalyses the first step of glycine betaine synthesis. In many bacteria, plants and animals, betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. Different enzymes are involved in the first reaction. In plants, the reaction is catalysed by this enzyme whereas in animals and many bacteria it is catalysed by either membrane-bound EC 1.1.99.1 (choline dehydrogenase) or soluble EC 1.1.3.17 (choline oxidase) [7]. The enzyme involved in the second step, EC 1.2.1.8 (betaine-aldehyde dehydrogenase), appears to be the same in plants, animals and bacteria. In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 (glycine/sarcosine N-methyltransferase) and EC 2.1.1.157 (sarcosine/dimethylglycine N-methyltransferase)." +"1.14.16.1","The active centre contains mononuclear iron(II). The reaction involves an arene oxide that rearranges to give the phenolic hydroxy group. This results in the hydrogen at C-4 migrating to C-3 and in part being retained. This process is known as the NIH-shift. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine." +"1.14.16.2","The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine." +"1.14.16.3",Requires Fe2+. The enzyme has been characterized from the leaves of the plant Tecoma stans (Yellow Bells). +"1.14.16.4","The active centre contains mononuclear iron(II). The enzyme is activated by phosphorylation, catalysed by a Ca2+-activated protein kinase. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine." +"1.14.16.5","The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens). Requires non-heme iron [7], reduced glutathione and phospholipids for full activity. The product spontaneously breaks down to form a fatty aldehyde and glycerol. The co-product, 4a-hydroxytetrahydropteridine, is rapidly dehydrated to 6,7-dihydropteridine, either spontaneously or by EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase." +"1.14.16.6","Requires Fe2+. The enzyme has been characterized from the bacterium Pseudomonas putida. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine." +"1.14.17.1","A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate." +"1.14.17.3","A copper protein. The enzyme binds two copper ions with distinct roles during catalysis. Peptidylglycines with a neutral amino acid residue in the penultimate position are the best substrates for the enzyme. The product is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide, a reaction catalysed by EC 4.3.2.5 peptidylamidoglycolate lyase. In mammals, the two activities are part of a bifunctional protein. Involved in the final step of biosynthesis of alpha-melanotropin and related biologically active peptides." +"1.14.17.4","A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethene has signalling functions such as stimulation of fruit-ripening." +"1.14.18.1","A type III copper protein found in a broad variety of bacteria, fungi, plants, insects, crustaceans, and mammals, which is involved in the synthesis of betalains and melanin. The enzyme, which is activated upon binding molecular oxygen, can catalyse both a monophenolase reaction cycle (reaction 1) or a diphenolase reaction cycle (reaction 2). During the monophenolase cycle, one of the bound oxygen atoms is transferred to a monophenol (such as L-tyrosine), generating an o-diphenol intermediate, which is subsequently oxidized to an o-quinone and released, along with a water molecule. The enzyme remains in an inactive deoxy state, and is restored to the active oxy state by the binding of a new oxygen molecule. During the diphenolase cycle the enzyme binds an external diphenol molecule (such as L-dopa) and oxidizes it to an o-quinone that is released along with a water molecule, leaving the enzyme in the intermediate met state. The enzyme then binds a second diphenol molecule and repeats the process, ending in a deoxy state [7]. The second reaction is identical to that catalysed by the related enzyme catechol oxidase (EC 1.10.3.1). However, the latter can not catalyse the hydroxylation or monooxygenation of monophenols." +"1.14.18.2",This enzyme contains both a Rieske-type [2Fe-2S] cluster and a second iron site. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2). The enzyme can be activated by Fe2+ or Fe3+. +"1.14.19.1","An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2)." +"1.14.19.2","The enzyme is found in the lumen of plastids, where de novo biosynthesis of fatty acids occurs, and acts on freshly synthesized saturated fatty acids that are still linked to acyl-carrier protein. The enzyme determines the position of the double bond by its distance from the carboxylic acid end of the fatty acid. It also acts on palmitoyl-[acyl-carrier-protein] [4,5]." +"1.14.19.3","An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA [4], and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate [3]. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase." +"1.14.20.1","Forms part of the penicillin biosynthesis pathway (for pathway, click here)." +"1.14.21.1",A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the second methylenedioxy bridge of the protoberberine alkaloid stylopine from oxidative ring closure of adjacent phenolic and methoxy groups of cheilanthifoline. +"1.14.21.2","A cytochrome P-450 (heme-thiolate) enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline by the oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine. cf. EC 1.14.21.12, (S)-nandinine synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-nandinine." +"1.14.21.3",A heme-thiolate enzyme (P-450). Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine. +"1.14.21.4",A heme-thiolate enzyme (P-450). Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product. +"1.14.21.5",A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that does not incorporate oxygen into the product. Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine. +"1.14.21.6","This enzyme catalyses the introduction of a C5 double bond into the B ring of Delta7-sterols to yield the corresponding Delta5,7-sterols in mammals, yeast and plants [4]. Forms part of the plant sterol biosynthesis pathway." +"1.14.99.1",This enzyme acts both as a dioxygenase and as a peroxidase. +"1.14.99.3","Requires NAD(P)H and EC 1.6.2.4, NADPH---hemoprotein reductase. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The central iron is kept in the reduced state by NAD(P)H." +"1.14.99.4","Has a wide specificity. A single enzyme from ascomycete the Neonectria radicicola (EC 1.14.13.54 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.12 androst-4-ene-3,17-dione monooxygenase." +"1.14.99.7","A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase." +"1.14.99.9","Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17alpha-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17alpha-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 4.1.2.30, 7alpha-hydroxyprogesterone aldolase). The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones." +"1.14.99.10","Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A heme-thiolate protein (P-450) enzyme responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol." +"1.14.99.12","Has a wide specificity. A single enzyme from the ascomycete Neonectria radicicola (EC 1.14.13.54, ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 1.14.99.4, progesterone monooxygenase." +"1.14.99.15","The bacterial enzyme consists of a ferredoxin-type protein and an iron-sulfur flavoprotein (FMN). Also acts on 4-ethoxybenzoate, N-methyl-4-aminobenzoate and toluate. The fungal enzyme acts best on veratrate." +"1.14.99.19",Requires NADPH or NADH. May involve cytochrome b5. Requires Mg2+ and ATP. +"1.14.99.21","A flavoprotein. Latia is a bioluminescent mollusc. The reaction possibly involves two enzymes, an oxygenase followed by a monooxygenase for the actual light-emitting step." +"1.14.99.22",An enzyme from insect fat body or malpighian tubules involving a heme-thiolate protein (P-450). NADPH can act as ultimate hydrogen donor. +"1.14.99.24",An enzyme system involving a flavoprotein (FMN) and two iron-sulfur proteins. +"1.14.99.26","Also oxidizes 2,5-dihydroxypyridine, but does not act on 3-hydroxypyridine, 4-hydroxypyridine or 2,6-dihydroxypyridine." +"1.14.99.27","Also acts on 1,4-naphthoquinone, naphthazarin and 2-chloro-1,4-naphthoquinone, but not on other related compounds." +"1.14.99.28",A heme-thiolate protein (P-450). +"1.14.99.29",The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A. +"1.14.99.30","Also acts on zeta-carotene twice to give lycopene and converts beta-zeacarotene to gamma-carotene, and pro-zeta-carotene to prolycopene (via double reaction)" +"1.14.99.31","Involved in sex pheromone synthesis in the moth Spodoptera littoralis. (E)-Tetradec-11-enoyl-CoA is formed by stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. EC 1.14.99.32, myristoyl-CoA 11-(Z) desaturase, forms the Z isomer by stereospecific cleavage of pro-R H at C-11 and C-12." +"1.14.99.32","Involved in sex pheromone synthesis in the moth Spodoptera littoralis. (Z)-11-Tetradecenoyl-CoA is formed by stereospecific removal of H from the pro-R positions at C-11 and C-12. EC 1.14.99.31, myristoyl-CoA 11-(E) desaturase, forms the (E)-isomer by removing the pro-R H group at C-11 and the pro-S H group at C-12." +"1.14.99.33",Contains non-heme iron. +"1.14.99.34","A flavoprotein (FAD) with high specificity for monoprenyl isoflavone. The product of the prenyl epoxidation reaction contains an oxygen atom derived from O2, but not from H2O. It is slowly and non-enzymically converted into the corresponding dihydrofurano derivative. The enzyme in the fungus Botrytis cinerea is induced by the substrate analogue, 6-prenylnaringenin." +"1.14.99.35",A molybdenum enzyme. Highly specific for thiophene-2-carbonyl-CoA. Tetrazolium salts can act as electron acceptors. +"1.14.99.36","Requires bile salts and Fe(II). This animal enzyme catalyses the reaction in three stages, epoxidation of the 15,15'-double bond, hydration of the epoxide leading to ring opening, and oxidative cleavage of the diol formed. Thus only one atom of the dioxygen is incorporated into each retinal molecule. The nature of the acceptor listed in reactions (1a) and (1c) is assumed to be iron within the active site. Formerly classified in EC 1.13.11 as it had been thought to be a dioxygenase. cf. EC 1.13.11.63, beta-carotene 15,15'-dioxygenase." +"1.14.99.37","This microsomal cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation." +"1.14.99.38","Unlike most other sterol hydroxylases, this enzyme is not a cytochrome P-450. Instead, it uses diiron cofactors to catalyse the hydroxylation of hydrophobic substrates [1]. The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to the enzyme through interactions with clustered histidine or glutamate residues [4,5]. In cell cultures, this enzyme down-regulates cholesterol synthesis and the processing of sterol regulatory element binding proteins (SREBPs). cf. EC 1.17.99.10, cholesterol C-25 hydroxylase." +"1.15.1.1","A metalloprotein; also known as erythrocuprein, hemocuprein or cytocuprein. Enzymes from most eukaryotes contain both copper and zinc; those from mitochondria and most prokaryotes contain manganese or iron." +"1.15.1.2",The enzyme contains non-heme iron. +"1.16.1.1",A dithiol enzyme. +"1.16.1.3",A flavoprotein. +"1.16.1.4",A flavoprotein. +"1.16.1.5","A flavoprotein. Acts on aquacob(III)alamin and hydroxycobalamin, but not on cyanocobalamin." +"1.16.1.6","The mammalian enzyme, which is cytosolic, can bind internalized cyanocobalamin and process it to cob(II)alamin by removing the upper axial ligand. The product remains bound to the protein, which, together with its interacting partner MMADHC, transfers it directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis. In addition to its decyanase function, the mammalian enzyme also catalyses an entirely different chemical reaction with alkylcobalamins, using the thiolate of glutathione for nucleophilic displacement, generating cob(I)alamin and the corresponding glutathione thioether (cf. EC 2.5.1.151, alkylcobalamin dealkylase)." +"1.16.1.7","Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 1.16.1.9, ferric-chelate reductase (NADPH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H]." +"1.16.1.8","In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia." +"1.16.3.1","The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a." +"1.16.8.1","This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH." +"1.17.1.1","The enzyme consists of two proteins. One forms an enzyme-bound adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine phosphate, in which the 3-hydroxy group has been removed. The second catalyses the reduction of this adduct by NAD(P)H and release of the CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate." +"1.17.1.2","An iron-sulfur protein that contains either a [3Fe-4S] [6] or a [4Fe-4S] [5] cluster. This enzyme comprises a system in which ferredoxin is first reduced and subsequently reoxidized by an NAD(P)+-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and dimethylallyl diphosphate." +"1.17.1.3","The enzyme catalyses the synthesis of catechin, catechin-4beta-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins. While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4-diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3,4-cis-leucopelargonidin can also act as substrates, but more slowly. NADH can replace NADPH but is oxidized more slowly." +"1.17.1.4","Acts on a variety of purines and aldehydes, including hypoxanthine. The mammalian enzyme can also convert all-trans retinol to all-trans-retinoate, while the substrate is bound to a retinoid-binding protein [14]. The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum centre. The mammalian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to an O2-dependent form, xanthine oxidase (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds [2,6,8,15] [which can be catalysed by EC 1.8.4.7, enzyme-thiol transhydrogenase (glutathione-disulfide) in the presence of glutathione disulfide] or limited proteolysis, which results in irreversible conversion. The conversion can also occur in vivo [2,7,15]." +"1.17.1.5","A flavoprotein containing non-heme iron. The enzyme is capable of acting on a variety of nicotinate analogues to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3-dicarboxylate, trigonelline and 6-methylnicotinate. The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide." +"1.17.1.6",This enzyme is highly specific for bile-acid substrates and requires a free C-24 carboxy group and an unhindered 7alpha-hydroxy group on the B-ring of the steroid nucleus for activity. May be regulated by the ratio of NAD+ to NADH [2]. +"1.17.3.1",Different from EC 1.17.3.2 xanthine oxidase; does not act on hypoxanthine. +"1.17.3.2","An iron-molybdenum flavoprotein (FAD) containing [2Fe-2S] centres. Also oxidizes hypoxanthine, some other purines and pterins, and aldehydes, but is distinct from EC 1.2.3.1, aldehyde oxidase. Under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 O2.- + 2 H+. The mammalian enzyme predominantly exists as an NAD-dependent dehydrogenase (EC 1.17.1.4, xanthine dehydrogenase). During purification the enzyme is largely converted to the O2-dependent xanthine oxidase form (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds [4,5,7,10] [which can be catalysed by EC 1.8.4.7, enzyme-thiol transhydrogenase (glutathione-disulfide) in the presence of glutathione disulfide] or limited proteolysis, which results in irreversible conversion. The conversion can also occur in vivo [4,6,10]." +"1.20.2.1","A molybdoprotein containing iron-sulfur clusters. Isolated from alpha-proteobacteria. Unlike EC 1.20.9.1, arsenate reductase (azurin), it does not use azurin as acceptor." +"1.17.3.3","Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid." +"1.17.4.1","This enzyme is responsible for the de novo conversion of ribonucleoside diphosphates into deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. There are three types of this enzyme differing in their cofactors. Class Ia enzymes contain a diiron(III)-tyrosyl radical, class Ib enzymes contain a dimanganese-tyrosyl radical, and class II enzymes contain adenosylcobalamin. In all cases the cofactors are involved in generation of a transient thiyl (sulfanyl) radical on a cysteine residue, which attacks the substrate, forming a ribonucleotide 3'-radical, followed by water loss to form a ketyl (alpha-oxoalkyl) radical. The ketyl radical is reduced to 3'-keto-deoxynucleotide concomitant with formation of a disulfide anion radical between two cysteine residues. A proton-coupled electron-transfer from the disulfide radical to the substrate generates a 3'-deoxynucleotide radical, and the final product is formed when the hydrogen atom that was initially removed from the 3'-position of the nucleotide by the thiyl radical is returned to the same position. The disulfide bridge is reduced by the action of thioredoxin. cf. EC 1.1.98.6, ribonucleoside-triphosphate reductase (formate) and EC 1.17.4.2, ribonucleoside-triphosphate reductase (thioredoxin)." +"1.17.4.2","The enzyme, characterized from the bacterium Lactobacillus leichmannii, is similar to class II ribonucleoside-diphosphate reductase (cf. EC 1.17.4.1). However, it is specific for the triphosphate versions of its substrates. The enzyme contains an adenosylcobalamin cofactor that is involved in generation of a transient thiyl (sulfanyl) radical on a cysteine residue. This radical attacks the substrate, forming a ribonucleotide 3'-radical, followed by water loss to form a ketyl (alpha-oxoalkyl) radical. The ketyl radical is reduced to 3'-keto-deoxynucleotide concomitant with formation of a disulfide anion radical between two cysteine residues. A proton-coupled electron-transfer from the disulfide radical to the substrate generates a 3'-deoxynucleotide radical, and the final product is formed when the hydrogen atom that was initially removed from the 3'-position of the nucleotide by the thiyl radical is returned to the same position. The disulfide bridge is reduced by the action of thioredoxin. cf. EC 1.1.98.6, ribonucleoside-triphosphate reductase (formate)." +"1.17.4.3","Forms, in the reverse direction, part of an alternative, nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here)." +"1.17.5.1","The enzyme from Thauera aromatica is a membrane-bound molybdenum---iron---sulfur protein. The enzyme is specific for phenylacetyl-CoA as substrate. Phenylacetate, acetyl-CoA, benzoyl-CoA, propanoyl-CoA, crotonyl-CoA, succinyl-CoA and 3-hydroxybenzoyl-CoA cannot act as substrates. The oxygen atom introduced into the product, phenylglyoxylyl-CoA, is derived from water and not molecular oxygen. Duroquinone, menaquinone and 2,6-dichlorophenolindophenol (DCPIP) can act as acceptor, but the likely physiological acceptor is ubiquinone [1]. A second enzyme, EC 3.1.2.25, phenylacetyl-CoA hydrolase, converts the phenylglyoxylyl-CoA formed into phenylglyoxylate." +"1.17.99.1",A flavocytochrome c (FAD). Phenazine methosulfate can act as acceptor. A quinone methide is probably formed as intermediate. The first hydroxylation forms 4-hydroxybenzyl alcohol; a second hydroxylation converts this into 4-hydroxybenzaldehyde. +"1.17.99.2","Involved in the anaerobic catabolism of ethylbenzene by denitrifying bacteria. Ethylbenzene is the preferred substrate; the enzyme from some strains oxidizes propylbenzene, 1-ethyl-4-fluorobenzene, 3-methylpent-2-ene and ethylidenecyclohexane. Toluene is not oxidized. p-Benzoquinone or ferrocenium can act as electron acceptor. Contains molybdopterin, [4Fe-4S] clusters and heme b." +"1.17.99.3","Requires ATP. The reaction in mammals possibly involves dehydrogenation to give a 24(25)-double bond followed by hydration [1]. However, in amphibians such as the Oriental fire-bellied toad (Bombina orientalis), it is probable that the product is formed via direct hydroxylation of the saturated side chain of (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate and not via hydration of a 24(25) double bond [5]. In microsomes, the free acid is preferred to the coenzyme A ester, whereas in mitochondria, the coenzyme A ester is preferred to the free-acid form of the substrate [1]." +"1.18.1.1","Requires FAD. The enzyme from Clostridium acetobutylicum reduces rubredoxin, ferricyanide and dichlorophenolindophenol, but not ferredoxin or flavodoxin. The reaction does not occur when NADPH is substituted for NADH. Contains iron at the redox centre." +"1.18.1.2","A flavoprotein (FAD). In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe-2S] ferredoxins, but in other bacteria it can also reduce bacterial [4Fe-4S] ferredoxins and flavodoxin." +"1.18.1.3","Contains FAD. Reaction (1) is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems. The alternative reaction (2) is written for a 2[4Fe-4S] ferredoxin, which transfers two electrons, and occurs in metabolism of anaerobic bacteria. " +"1.18.1.4","The enzyme from Pyrococcus furiosus requires FAD. It reduces a number of electron carriers, including benzyl viologen, menadione and 2,6-dichloroindophenol, but rubredoxin is the most efficient. Ferredoxin is not utilized." +"1.18.6.1","Requires Mg2+. The enzyme is a complex of two components (namely dinitrogen reductase and dinitrogenase). Dinitrogen reductase is a [4Fe-4S] protein, which, in the presence of two molecules of ATP, transfers an electron from ferredoxin to the dinitrogenase component. Dinitrogenase is a molybdenum-iron protein that reduces dinitrogen to two molecules of ammonia in three successive two-electron reductions via diazene and hydrazine. The reduction is initiated by formation of hydrogen in stoichiometric amounts [2]. Acetylene is reduced to ethylene (but only very slowly to ethane), azide to nitrogen and ammonia, and cyanide to methane and ammonia. In the absence of a suitable substrate, hydrogen is slowly formed. Ferredoxin may be replaced by flavodoxin [see EC 1.19.6.1 nitrogenase (flavodoxin)]. The enzyme does not reduce CO (cf. EC 1.18.6.2, vanadium-dependent nitrogenase)." +"1.19.6.1","Requires Mg2+. It is composed of two components, dinitrogen reductase and dinitrogenase, that can be separated but are both required for nitrogenase activity. Dinitrogen reductase is a [4Fe-4S] protein, which, at the expense of ATP, transfers electrons from a dedicated flavodoxin to dinitrogenase. Dinitrogenase is a protein complex that contains either a molybdenum-iron cofactor, a vanadium-iron cofactor, or an iron-iron cofactor, that reduces dinitrogen in three succesive two-electron reductions from nitrogen to diimine to hydrazine to two molecules of ammonia. The reduction is initiated by formation of hydrogen. The enzyme can also reduce acetylene to ethylene (but only very slowly to ethane), azide to nitrogen and ammonia, and cyanide to methane and ammonia. In the absence of a suitable substrate, hydrogen is slowly formed. Some enzymes utilize ferredoxin rather than flavodoxin as the electron donor (see EC 1.18.6.1, nitrogenase)." +"1.20.1.1",NADP+ is a poor substitute for NAD+ in the enzyme from Pseudomonas stutzeri WM88. +"1.20.4.1","The enzyme is part of a system for detoxifying arsenate. The substrate binds to a catalytic cysteine residue, forming a covalent thiolate---As(V) intermediate. A tertiary intermediate is then formed between the arsenic, the enzyme's cysteine, and a glutathione cysteine. This intermediate is reduced by glutaredoxin, which forms a dithiol with the glutathione, leading to the dissociation of arsenite. Thus reduction of As(V) is mediated by three cysteine residues: one in ArsC, one in glutathione, and one in glutaredoxin. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. cf. EC 1.20.4.4, arsenate reductase (thioredoxin)." +"1.20.4.4","The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin [1]. It has no activity with glutaredoxin [cf. EC 1.20.4.1, arsenate reductase (glutaredoxin)]. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. The enzyme also has the activity of EC 3.1.3.48, protein-tyrosine-phosphatase [3]." +"1.20.4.2","The product, methylarsonite, is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid." +"1.20.98.1","Contains a molybdopterin centre comprising two molybdopterin guanosine dinucleotide cofactors bound to molybdenum, a [3Fe-4S] cluster and a Rieske-type [2Fe-2S] cluster. Also uses a c-type cytochrome or O2 as acceptors." +"1.20.99.1","Benzyl viologen can act as an acceptor. Unlike EC 1.20.4.1, arsenate reductase (glutaredoxin), reduced glutaredoxin cannot serve as a reductant." +"1.21.3.1","Forms part of the penicillin biosynthesis pathway (for pathway, click here)." +"1.21.3.2",An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine. +"1.21.3.3","Contains FAD. The enzyme from the plant Eschscholtzia californica binds the cofactor covalently [3]. Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)-tetrahydroprotoberberines. The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants." +"1.21.3.4","Also acts on several diphenols and phenylenediamines, but has low affinity for these substrates. Involved in the biosynthesis of mould metabolites related to the antibiotic griseofulvin." +"1.21.3.5","Also acts on several diphenols and phenylenediamines, but has low affinity for these substrates. Involved in the biosynthesis of mould metabolites related to the antibiotic griseofulvin." +"1.21.3.6","A copper-containing glycoprotein that plays a key role in the yellow coloration of flowers such as Antirrhinum majus (snapdragon). The enzyme is a homologue of plant polyphenol oxidase [1] and catalyses two separate chemical transformations, i.e. 3-hydroxylation and oxidative cyclization (2',-dehydrogenation). H2O2 activates reaction (1) but inhibits reaction (2). Originally considered to act on the phenol but now thought to act mainly on the 4'-O-beta-D-glucoside in vivo [4]." +"1.21.4.1","A pyruvoyl- and L-selenocysteine-containing enzyme found in a number of Clostridial species. The pyruvoyl group, located on the PrdA subunit, binds the substrate, while the selenocysteine residue, located on the PrdB subunit, attacks the alpha-C-atom of D-proline, leading to a reductive cleavage of the C-N-bond of the pyrrolidine ring and formation of a selenoether. The selenoether is cleaved by a cysteine residue of PrdB, resulting in a mixed selenide-sulfide bridge, which is restored to its reduced state by another selenocysteine protein, PrdC. 5-aminopentanoate is released from PrdA by hydrolysis, regenerating the pyruvoyl moiety. The resulting mixed selenide-sulfide bridge in PrdC is reduced by NADH." +"1.21.4.2","The reaction is observed only in the direction of glycine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for glycine binding and ammonia release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.3 (sarcosine reductase) and EC 1.21.4.4 (betaine reductase)." +"1.21.4.3","The reaction is observed only in the direction of sarcosine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.4 (betaine reductase)." +"1.21.4.4","The reaction is observed only in the direction of betaine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for betaine binding and trimethylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC 1.21.4.2 (glycine reductase) and EC 1.21.4.3 (sarcosine reductase)." +"1.21.99.1",A flavoprotein (FAD). Cytochrome c and various dyes can act as acceptor. Cyclopiazonate is a microbial toxin. +"1.97.1.1",Flavins or benzylviologen can act as acceptor. +"1.97.1.2","1,2,3,5-Tetrahydroxybenzene acts as a co-substrate for the conversion of pyrogallol into phloroglucinol, and for a number of similar isomerizations. The enzyme is provisionally listed here, but might be considered as the basis for a new class in the transferases, analogous to the aminotransferases." +"1.97.1.3","Sulfur can be reduced with hydrogen as donor in the presence of hydrogenase, or by photochemical reduction in the presence of phenosafranin." +"1.97.1.4","An iron-sulfur protein. A single glycine residue in EC 2.3.1.54, formate C-acetyltransferase, is oxidized to the corresponding radical by transfer of H from its CH2 to AdoMet with concomitant cleavage of the latter. The reaction requires Fe2+. The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen radical from the glycine residue." +"1.97.1.8","This enzyme allows the common pollutant tetrachloroethene to support bacterial growth and is responsible for disposal of a number of chlorinated hydrocarbons by this organism. The reaction occurs in the reverse direction. The enzyme also reduces trichloroethene to dichloroethene. Although the physiological reductant is unknown, the supply of reductant in some organisms is via reduced menaquinone, itself formed from molecular hydrogen, via EC 1.12.5.1 (hydrogen:quinone oxidoreductase). The enzyme contains a corrinoid and two iron-sulfur clusters. Methyl viologen can act as electron donor." +"1.97.1.9","The periplasmic enzyme from the bacterium Thauera selenatis is a complex comprising three heterologous subunits (alpha, beta and gamma) that contains a guanylyl molybdenum cofactor, as well as multiple iron-sulfur clusters and heme b. The enzyme reduces selenate to selenite using electrons provided by a diheme cytochrome c4, which receives the electrons from the membrane quinone pool via EC 7.1.1.8, quinol---cytochrome-c reductase. Nitrate, nitrite, chlorate and sulfate are not substrates." +"1.97.1.10","The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide." +"1.97.1.11","The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine. " +"2.1.1.4","Some other hydroxyindoles also act as acceptor, but more slowly." +"2.1.1.6",The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols. +"2.1.1.9","H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors." +"2.1.1.10",The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine. +"2.1.1.12",Requires Zn2+ or Mn2+ +"2.1.1.13","Contains zinc and cobamide. The enzyme becomes inactivated occasionally during its cycle by oxidation of Co(I) to Co(II). Reactivation by reductive methylation is catalysed by the enzyme itself, with S-adenosyl-L-methionine as the methyl donor and a reducing system. For the mammalian enzyme, the reducing system involves NADPH and EC 1.16.1.8, [methionine synthase] reductase. In bacteria, the reducing agent is flavodoxin, and no further catalyst is needed (the flavodoxin is kept in the reduced state by NADPH and EC 1.18.1.2, ferredoxin---NADP+ reductase). Acts on the monoglutamate as well as the triglutamate folate, in contrast with EC 2.1.1.14, 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase, which acts only on the triglutamate." +"2.1.1.14","Requires phosphate and contains zinc. The enzyme from Escherichia coli also requires a reducing system. Unlike EC 2.1.1.13, methionine synthase, this enzyme does not contain cobalamin." +"2.1.1.15",Oleic acid is the most effective fatty acid acceptor. +"2.1.1.16","The enzyme transfers a methyl group to the 10-position of a Delta-olefinic acyl chain in phosphatidylglycerol or phosphatidylinositol or, more slowly, phosphatidylethanolamine; subsequent proton transfer produces a 10-methylene group (cf. EC 2.1.1.79 cyclopropane-fatty-acyl-phospholipid synthase)." +"2.1.1.20","This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate [4]. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase." +"2.1.1.25","Acts on a wide variety of simple alkyl-, methoxy- and halo-phenols." +"2.1.1.27",Has some activity on phenylethylamine analogues. +"2.1.1.28",Acts on various phenylethanolamines; converts noradrenaline into adrenaline. +"2.1.1.32","In eukaryotic tRNAs, two N2-guanine methylations occur, at the N2-methylguanine at position 10 and the N2-methylguanine at position 29." +"2.1.1.33",The enzyme specifically methylates guanine46 at N7 in tRNA. +"2.1.1.34",The enzyme catalyses the methylation of guanosine18 in tRNA. +"2.1.1.208","Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2'-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA." +"2.1.1.35","Unlike this enzyme, EC 2.1.1.74 (methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing)), uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54 [4]. " +"2.1.1.36",The enzymes from different sources are specific for different adenine residues in tRNA. +"2.1.1.38",Puromycin is the antibiotic derived from N6-dimethyladenosine by replacing the 3'-hydroxy group with an amino group and acylating this with 4-O-methyltyrosine. +"2.1.1.41","Requires glutathione. Acts on a range of sterols with a 24(25)-double bond in the sidechain. While zymosterol is the preferred substrate it also acts on desmosterol, 5alpha-cholesta-7,24-dien-3beta-ol, 5alpha-cholesta-5,7,24-trien-3beta-ol, 4alpha-methylzymosterol and others. S-Adenosyl-L-methionine attacks the Si-face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond." +"2.1.1.42","The enzyme prefers flavones with vicinal 3',4'-dihydroxyl groups. " +"2.1.1.233","Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes. " +"2.1.1.43","One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase." +"2.1.1.44",Part of the biosynthetic pathway of ergothioneine. +"2.1.1.46","Requires Mg2+ for activity. The enzyme catalyses the methylation of daidzein and genistein. It does not methylate naringenin, apigenin, luteolin or kaempferol." +"2.1.1.47","The enzyme, characterized from the bacterium Streptomyces griseus, is involved in the biosynthesis of the antibacterial drug indolmycin." +"2.1.1.48",Also methylates 2-aminoadenosine to 2-methylaminoadenosine. +"2.1.1.49","An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics." +"2.1.1.50",Also acts on secologanate. Methylates the 11-carboxy group of the monoterpenoid loganate. +"2.1.1.54","dCMP is methylated by formaldehyde in the presence of tetrahydrofolate. CMP, dCTP and CTP can act as acceptors, but more slowly." +"2.1.1.56",The terminal N7-methylguanosine facilitates gene expression in eukaryotic cells and is recognized by cap-binding proteins. +"2.1.1.57","This enzyme catalyses the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules. This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine [6]." +"2.1.1.59",One of a group of enzymes methylating proteins; see also the family of histone-lysine N-methyltransferases (previously EC 2.1.1.43) and EC 2.1.1.60 calmodulin-lysine N-methyltransferase. +"2.1.1.60",One of a group of enzymes methylating proteins; see also the family of histone-lysine N-methyltransferases (previously EC 2.1.1.43) and EC 2.1.1.59 [cytochrome c]-lysine N-methyltransferase. +"2.1.1.61",This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate. +"2.1.1.63","This protein is involved in the repair of methylated DNA. Unlike EC 3.2.2.20, DNA-3-methyladenine glycosidase I and EC 3.2.2.21, DNA-3-methyladenine glycosidase II, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide. Since the methyl transfer is irreversible, the enzyme can only catalyse a single turnover." +"2.1.1.64","This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast [3]. The enzymes from yeast, Escherichia coli and rat also catalyse the methylation of 3,4-dihydroxy-5-all-trans-polyprenylbenzoate [3] (a reaction that is classified as EC 2.1.1.114, polyprenyldihydroxybenzoate methyltransferase)." +"2.1.1.65","As well as licodione [1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione], the 2''-hydroxy-derivative and isoliquiritigenin can act as acceptors, but more slowly." +"2.1.1.67","Also acts, more slowly, on thiopyrimidines and aromatic thiols. Not identical with EC 2.1.1.9 thiol S-methyltransferase." +"2.1.1.68","3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, but more slowly." +"2.1.1.69","Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin [3], but has little activity on non-coumarin phenols [1]. Caffeate, 5-hydroxyferulate and daphnetin are not substrates [4]. Cu2+, Zn2+ and Co2+ cause enzyme inhibition [4]. (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase)" +"2.1.1.70","Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase). " +"2.1.1.71","The enzyme also catalyses the transfer of a further methyl group, producing phosphatidylcholine." +"2.1.1.72","This is a large group of enzymes, most of which form so-called 'restriction-modification systems' with nucleases that possess similar site specificity [the nucleases are listed as either EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease)]. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html." +"2.1.1.74","A flavoprotein (FAD). Up to 25% of the bases in mature tRNA are post-translationally modified or hypermodified. One almost universal post-translational modification is the conversion of U54 into ribothymidine in the TPsiC loop, and this modification is found in most species studied to date [2]. Unlike this enzyme, which uses 5,10-methylenetetrahydrofolate and NAD(P)H to supply the atoms for methylation of U54, EC 2.1.1.35, tRNA (uracil54-C5)-methyltransferase, uses S-adenosyl-L-methionine." +"2.1.1.75","Converts apigenin into acacetin. Naringenin can also act as an acceptor, but more slowly." +"2.1.1.76","Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol." +"2.1.1.77",D-Aspartate (but not L-aspartate) residues in proteins can also act as acceptors. Previously also listed as EC 2.1.1.24. +"2.1.1.78",Also acts on isoorientin 2''-O-rhamnoside. Involved in the biosynthesis of flavones. +"2.1.1.79","The enzyme adds a methylene group across the 9,10 position of a Delta9-olefinic acyl chain in phosphatidylethanolamine or, more slowly, phosphatidylglycerol or phosphatidylinositol, forming a cyclopropane derivative (cf. EC 2.1.1.16 methylene-fatty-acyl-phospholipid synthase)." +"2.1.1.80",Forms ester groups with L-glutamate residues in a number of membrane proteins. +"2.1.1.82","Involved with EC 2.1.1.76 quercetin 3-O-methyltransferase and EC 2.1.1.83 3,7-dimethylquercetin 4'-O-methyltransferase in the methylation of quercetin to 3,7,4'-trimethylquercetin in Chrysosplenium americanum. Does not act on flavones, dihydroflavonols, or their glucosides." +"2.1.1.83","3,7-Dimethylquercetagetin can also act as acceptor. Involved with EC 2.1.1.76 quercetin 3-O-methyltransferase and EC 2.1.1.82 3-methylquercetin 7-O-methyltransferase in the methylation of quercetin to 3,7,4'-trimethylquercetin in Chrysosplenium americanum. Does not act on flavones, dihydroflavonols, or their glucosides." +"2.1.1.84","The enzymes from Chrysosplenium americanum also methylates 3,7,3'-trimethylquercetagetin at the 6-position. Does not act on flavones, dihydroflavonols, or their glucosides." +"2.1.1.85","Highly specific for histidine residues, for example, in actin." +"2.1.1.86","Involved in the formation of methane from CO2 in methanogenic archaea. The reaction involves the export of one or two sodium ions. The enzyme from the archaeon Methanobacterium thermoautotrophicum is a membrane-associated multienzyme complex composed of eight different subunits, and contains a 5'-hydroxybenzimidazolyl-cobamide cofactor, to which the methyl group is attached during the transfer. A soluble enzyme that is induced by the presence of CO has been reported as well [6]." +"2.1.1.88","Also acts on 8-hydroxykaempferol, but not on the glycosides of 8-hydroxyflavonols. An enzyme from the flower buds of Lotus corniculatus." +"2.1.1.89",Involved in the biosynthesis of the berberine alkaloids. +"2.1.1.90","The enzyme, which catalyses the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. Free cob(I)alamin can substitute for the corrinoid protein in vitro [2]. +Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen." +"2.1.1.91",Oximes of C4 to C6 aldehydes can act as acceptors; the most active substrate is 2-methylbutyroaldoxime. +"2.1.1.93","Also acts on 5-hydroxyxanthotoxin, formingisopimpinellin." +"2.1.1.94","Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus." +"2.1.1.95",The enzymes from plants and photosynthetic bacteria have similar efficiency with the gamma and delta isomers of tocopherols and tocotrienols. +"2.1.1.96","Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers." +"2.1.1.97",Involved in the biosynthesis of the antibiotic actinomycin in Streptomyces antibioticus. +"2.1.1.98","This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14, diphthine---ammonia ligase. Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314). In the archaeon Pyrococcus horikoshii the enzyme acts on His600 of elongation factor 2." +"2.1.1.99",Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle Catharanthus roseus. +"2.1.1.100","C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly." +"2.1.1.101","Requires Mg2+, Mn2+ or Co2+. The 3-hydroxy group of the 2-O-methyl-6-deoxy-D-allose moiety in the macrolide antibiotic macrosin acts as methyl acceptor, generating tylosin, another macrolide antibiotic. Isolated from the bacterium Streptomyces fradiae. Not identical with EC 2.1.1.102, demethylmacrocin O-methyltransferase." +"2.1.1.102","Requires Mg2+. The enzyme, isolated from the bacterium Streptomyces fradiae, is involved in the biosynthesis of the macrolide antibiotic tylosin. The 2-hydroxy group of a 6-deoxy-D-allose moiety in demethylmacrocin acts as the methyl acceptor. Also acts on demethyllactenocin, giving lactenocin. Not identical with EC 2.1.1.101 macrocin O-methyltransferase." +"2.1.1.103",The enzyme may catalyse the transfer of two further methyl groups to the product. +"2.1.1.105",Involved in the biosynthesis of phytoalexins. +"2.1.1.106","The enzyme, characterized from the bacterium Streptomyces laurentii, is involved in thiostrepton biosynthesis. It is a radical SAM enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. It has an exceptional reaction mechanism as the S-adenosyl-L-methionine (SAM) is not bound to the [4Fe-4S] center and does not produce a 5'-deoxyadenosyl radical but instead is believed to be involved in binding of the L-tryptophan substrate. After transfer of the methyl group from methylcob(III)alaminIn a methyl transfer from SAM to the generated cob(I)alamin takes place, preparing the enzyme for the next catalytic cycle. The original methyl group configuration is preserved." +"2.1.1.107","This enzyme catalyses two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III. The second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76, precorrin-2 dehydrogenase) and the third step involves the chelation of Fe2+ to sirohydrochlorin to form siroheme (EC 4.99.1.4, sirohydrochlorin ferrochelatase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction. Also involved in the biosynthesis of cobalamin." +"2.1.1.108","3,4-Dehydro-6-hydroxymellein can also act as acceptor. 6-Methoxymellein is a phytoalexin produced by carrot tissue." +"2.1.1.109",Dihydrodemethylsterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi. +"2.1.1.110",Dihydrosterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi. +"2.1.1.111",Involved in the biosynthesis of acridine alkaloids in plant tissues. +"2.1.1.113","This is a large group of enzymes, most of which, with enzymes of similar site specificity listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease), form so-called 'restriction-modification systems'. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html." +"2.1.1.114","This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast [3]. The enzymes from yeast and rat also catalyse the methylation of 3-demethylubiquinol-6 and 3-demethylubiquinol-9, respectively [2] (this activity is classified as EC 2.1.1.64, 3-demethylubiquinol 3-O-methyltransferase). " +"2.1.1.115","Broad substrate specificity for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine. Both R- and S-enantiomers are methylated. The enzyme participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants. The physiological substrate is likely to be coclaurine. The enzyme was earlier termed norreticuline N-methyltransferase. However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinolines." +"2.1.1.116","Involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (RS)-laudanosoline, (S)-3'-hydroxycoclaurine and (RS)-7-O-methylnorlaudanosoline." +"2.1.1.117",The product of this reaction is a precursor for protoberberine alkaloids in plants +"2.1.1.118","The product of this reaction is a protoberberine alkaloid that is widely distributed in the plant kingdom. This enzyme is distinct in specificity from EC 2.1.1.88, 8-hydroxyquercetin 8-O-methyltransferase." +"2.1.1.119",This reaction is part of the pathway for synthesis of benzophenanthridine alkaloids in plants. +"2.1.1.120",This reaction is part of the pathway for synthesis of benzophenanthridine alkaloid macarpine in plants. +"2.1.1.121",Nororientaline is a precursor of the alkaloid papaverine. +"2.1.1.122","Involved in the biosynthesis of isoquinoline alkaloids in plants. Substrates include (S)-canadine, (S)-stylopine, and (S)-tetrahydropalmatine. " +"2.1.1.123",The enzyme from Euglena gracilis methylates Met-65 of horse heart cytochrome c. +"2.1.1.124","The enzyme from Euglena gracilis methylates Arg-38 of horse heart cytochrome c to form the Nomega-monomethyl-arginine derivative. This enzyme was previously listed together with EC 2.1.1.25 phenol O-methyltransferase and EC 2.1.1.26 iodophenol O-methyltransferase as a single, now deleted, entry (EC 2.1.1.23, protein-arginine N-methyltransferase)." +"2.1.1.125","The enzyme forms the Nomega-monomethyl- and Nomega,Nomega'-dimethyl, but not the Nomega,Nomega-dimethyl-arginine derivatives. The name protein methylase I is misleading since it has been used for a number of enzymes with different specificities." +"2.1.1.126","The enzyme from mammalian brain forms the Nomega-monomethyl-, Nomega,Nomega-dimethyl- and Nomega,Nomega'-dimethyl-arginine derivatives. The name protein methylase I is misleading since it has been used for a number of enzymes with different specificities." +"2.1.1.127",The enzyme catalyses three successive methylations of Lys-14 in the large subunits of hexadecameric higher plant ribulose-bisphosphate-carboxylase (EC 4.1.1.39). Only the three methylated form is observed [3]. The enzyme from pea (Pisum sativum) also three-methylates a specific lysine in the chloroplastic isoforms of fructose-bisphosphate aldolase (EC 4.1.2.13) [5]. +"2.1.1.128","The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants." +"2.1.1.129","The enzyme from the rice bean Vigna umbellata (Fabaceae) is highly specific for S-adenosyl-L-methionine. The enzyme also methylates 1L-1,2,4/3,5-cyclohexanepentol, 2,4,6/3,5-pentahydroxycyclohexanone, D,L-2,3,4,6/5-pentacyclohexanone and 2,2'-anhydro-2-C-hydroxymethyl-myo-inositol, but at lower rates than that of myo-inositol." +"2.1.1.130","This enzyme participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway. See EC 2.1.1.151, cobalt-factor II C20-methyltransferase, for the equivalent enzyme that participates in the anaerobic cobalamin biosynthesis pathway." +"2.1.1.131","The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. See EC 2.1.1.272, cobalt-factor III methyltransferase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway." +"2.1.1.132","The enzyme participates in the aerobic (late cobalt insertion) adenosylcobalamin biosynthesis pathway. The enzyme from the bacterium Pseudomonas denitrificans is a fusion protein with two active sites; one catalyses the methylation at C-15 followed by decarboxylation of the C-12 acetate side chain, while the other catalyses the methylation at C-5. The corresponding activities in the anaerobic adenosylcobalamin biosynthesis pathway are catalysed by EC 2.1.1.196, cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating], and EC 2.1.1.289, cobalt-precorrin-7 (C5)-methyltransferase, respectively." +"2.1.1.133","In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A. The first of the four steps is carried out by EC 1.14.13.83, precorrin-3B synthase (CobG), yielding precorrin-3B as the product. This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to precorrin-4, precorrin-5, and precorrin-6A, respectively. See EC 2.1.1.271, cobalt-precorrin-4 methyltransferase, for the C11-methyltransferase enzyme that participates in the anaerobic cobalamin biosynthesis pathway." +"2.1.1.136","The enzyme from the fungus Trichoderma sp. virgatum, when cultured in the presence of halogenated phenol, also acts on a range of mono-, di- and trichlorophenols." +"2.1.1.137","An enzyme responsible for synthesis of trivalent methylarsenical antibiotics in microbes [11] or detoxification of inorganic arsenous acid in animals. The in vivo substrate is arsenic triglutathione or similar thiol (depending on the organism) [6], from which the arsenic is transferred to the enzyme forming bonds with the thiol groups of three cysteine residues [10] via a disulfide bond cascade pathway [7, 8]. Most of the substrates undergo two methylations and are converted to dimethylarsinous acid [9]. However, a small fraction are released earlier as methylarsonous acid, and a smaller amount proceeds via a third methylation, resulting in the volatile product trimethylarsane. Methylation involves temporary oxidation to arsenic(V) valency, followed by reduction back to arsenic(III) valency using electrons provided by thioredoxin or a similar reduction system. The arsenic(III) products are quickly oxidized in the presence of oxygen to the corresponding arsenic(V) species." +"2.1.1.139","Catalyses the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C." +"2.1.1.140",The enzyme is specific for the (S)-isomer of coclaurine. Norcoclaurine can also act as an acceptor. +"2.1.1.141","9,10-Dihydrojasmonic acid is a poor substrate for the enzyme. The enzyme does not convert 12-oxo-phytodienoic acid (a precursor of jasmonic acid), salicylic acid, benzoic acid, linolenic acid or cinnamic acid into their corresponding methyl esters. Enzyme activity is inhibited by the presence of divalent cations, e.g., Ca2+, Cu2+, Mg2+ and Zn2+." +"2.1.1.142",S-Adenosyl-L-methionine methylates the Si face of the 24(25)-double bond with elimination of a hydrogen atom from the pro-Z methyl group at C-25. +"2.1.1.143","This is the second methylation step of plant sterol biosynthesis (cf EC 2.1.1.142, cycloartenol 24-C-methyltransferase)." +"2.1.1.144","Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145, trans-aconitate 3-methyltransferase)." +"2.1.1.145","Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase)" +"2.1.1.146",Acts on eugenol and chavicol as well as isoeugenol. +"2.1.1.147","Also acts on 7,8-dihydropalmatine." +"2.1.1.148","Contains FAD. All thymidylate synthases catalyse a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5 position of dUMP and a two electron reduction of the methylene group to a methyl group. Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin cofactor as a source of reducing equivalents, which are derived from NADPH." +"2.1.1.149",The enzyme from Catharanthus roseus (Madagascar periwinkle) is unusual as it carries out two methylations of the same substrate. Also catalyses the methylation of dihydromyricetin. +"2.1.1.150","The enzyme from alfalfa can methylate daidzein, genistein and 6,7,4'-trihydroxyisoflavone but not flavones or flavanones." +"2.1.1.151","This enzyme participates in the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway. See EC 2.1.1.130, precorrin-2 C20-methyltransferase, for the equivalent enzyme that participates in the aerobic cobalamin biosynthesis pathway." +"2.1.1.152","The enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosythesis pathway, catalyses two reactions -the methylation of carbon C1 of precorrin-5, and its deacetylation, forming precorrin-6A. See EC 2.1.1.195, cobalt-precorrin-5B (C1)-methyltransferase, for the C1-methyltransferase that participates in the anaerobic cobalamin biosynthesis pathway." +"2.1.1.153",The flavonoids vitexin and isovitexin 2''-O-arabinoside do not act as substrates for the enzyme from oats (Avena sativa). +"2.1.1.154","Not identical to EC 2.1.1.65, licodione 2'-O-methyltransferase [2]. While EC 2.1.1.154, isoliquiritigenin 2'-O-methyltransferase can use licodione as a substrate, EC 2.1.1.65 cannot use isoliquiritigenin as a substrate." +"2.1.1.155","The enzyme acts on the hydroxy group in the 4'-position of some flavones, flavanones and isoflavones. Kaempferol, apigenin and kaempferol triglucoside are substrates, as is genistein, which reacts more slowly. Compounds with an hydroxy group in the 3' and 4' positions, such as quercetin and eriodictyol, do not act as substrates. Similar to EC 2.1.1.75, apigenin 4'-O-methyltransferase and EC 2.1.1.83, 3,7-dimethylquercetin 4'-O-methyltransferase." +"2.1.1.156","Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase. Differs from EC 2.1.1.20, glycine N-methyltransferase, as it can further methylate the product of the first reaction. Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction [3]." +"2.1.1.157","Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. The first enzyme, EC 2.1.1.156, glycine/sarcosine N-methyltransferase, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme. Both of these enzymes can catalyse the formation of N,N-dimethylglycine from sarcosine [3]. The reactions are strongly inhibited by S-adenosyl-L-homocysteine." +"2.1.2.1","A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine." +"2.1.2.2","Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme utilizes 10-formyltetrahydrofolate as the formyl donor, while the other enzyme, EC 6.3.1.21, phosphoribosylglycinamide formyltransferase 2, utilizes formate. In vertebrates this activity is catalysed by a trifunctional enzyme that also catalyses the activities of EC 6.3.4.13, phosphoribosylamine---glycine ligase and EC 6.3.3.1, phosphoribosylformylglycinamidine cyclo-ligase." +"2.1.2.5","The enzyme also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate. In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity." +"2.1.2.7",Also acts on 2-hydroxymethylserine. +"2.1.2.10","A component, with EC 1.4.4.2 glycine dehydrogenase (decarboxylating) and EC 1.8.1.4, dihydrolipoyl dehydrogenanse, of the glycine cleavage system, formerly known as glycine synthase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein [3]." +"2.1.3.1","A biotinyl-protein, containing cobalt and zinc. The enzyme, described from the bacterium Propionibacterium shermanii, is unique among the biotin-dependent enzymes in that it catalyses carboxyl transfer between two organic molecules, utilizing two separate carboxyltransferase domains. The enzyme is a very large complex, consisting of a hexameric central core of 12S subunits surrounded by six 5S subunit dimers, each connected to the central core by twelve 1.3S biotin carrier subunits." +"2.1.3.3","The plant enzyme also catalyses the reactions of EC 2.1.3.6 putrescine carbamoyltransferase, EC 2.7.2.2 carbamate kinase and EC 3.5.3.12 agmatine deiminase, thus acting as putrescine synthase, converting agmatine [(4-aminobutyl)guanidine] and ornithine into putrescine and citrulline, respectively." +"2.1.3.6","The plant enzyme also catalyses the reactions of EC 2.1.3.3 ornithine carbamoyltransferase, EC 2.7.2.2 carbamate kinase and EC 3.5.3.12 agmatine deiminase, thus acting as putrescine synthase, converting agmatine [(4-aminobutyl)guanidine] and ornithine into putrescine and citrulline, respectively." +"2.1.3.7",Acts on a wide range of 3-hydroxymethylcephems (a subclass of the cephalosporin antibiotics). Activated by ATP. +"2.1.3.8",Not identical with EC 2.1.3.3 ornithine carbamoyltransferase. +"2.1.3.9","Differs from EC 2.1.3.3, ornithine carbamoyltransferase. This enzyme replaces EC 2.1.3.3 in the canonic arginine biosynthetic pathway of several Eubacteria and has no catalytic activity with L-ornithine as substrate." +"2.1.4.1",Canavanine can act instead of arginine. +"2.1.4.2","1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor." +"2.2.1.1","A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor." +"2.2.1.3",A thiamine-diphosphate protein. Not identical with EC 2.2.1.1 transketolase. Also converts hydroxypyruvate and formaldehyde into glycerone and CO2. +"2.2.1.4",A thiamine-diphosphate protein. +"2.2.1.5",The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate. +"2.2.1.6","This enzyme requires thiamine diphosphate. The reaction shown is in the pathway of biosynthesis of valine; the enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine." +"2.2.1.7","Requires thiamine diphosphate. The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA})." +"2.2.1.8","A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate." +"2.3.1.1","Also acts with L-aspartate and, more slowly, with some other amino acids." +"2.3.1.2",Also acts with propanoyl-CoA. +"2.3.1.5","Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA." +"2.3.1.6","Propanoyl-CoA can act, more slowly, in place of acetyl-CoA." +"2.3.1.7",Also acts on propanoyl-CoA and butanoyl-CoA (cf. EC 2.3.1.21 carnitine O-palmitoyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase). +"2.3.1.8",Also acts with other short-chain acyl-CoAs. +"2.3.1.9","The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase." +"2.3.1.11","2-Sulfanylethan-1-ol (2-mercaptoethanol) can act as a substrate [1]." +"2.3.1.12","A multimer (24-mer or 60-mer, depending on the source) of this enzyme forms the core of the pyruvate dehydrogenase multienzyme complex, and binds tightly both EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively acetylated by EC 1.2.4.1, and the only observed direction catalysed by EC 2.3.1.12 is that where the acetyl group is passed to coenzyme A." +"2.3.1.13","The CoA derivatives of a number of aliphatic and aromatic acids, but not phenylacetyl-CoA or (indol-3-yl)acetyl-CoA, can act as donor. Not identical with EC 2.3.1.68 glutamine N-acyltransferase or EC 2.3.1.71 glycine N-benzoyltransferase." +"2.3.1.15",Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of fatty acids of chain length larger than C10. +"2.3.1.16","The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase." +"2.3.1.18",Acts on thiogalactosides and phenylgalactoside. +"2.3.1.20",Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. +"2.3.1.21","Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase." +"2.3.1.22","Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate." +"2.3.1.23",Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor. +"2.3.1.24",Acts on sphingosine or its 2-epimer. +"2.3.1.26","The enzyme catalyses the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A. The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA. In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol. In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of `foam cells', a hallmark of early atherosclerotic lesions. In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell." +"2.3.1.29","This is a pyridoxal-phosphate-dependent enzyme that acts in concert with EC 1.1.1.103, L-threonine 3-dehydrogenase, in the degradation of threonine to form glycine [3]. This threonine degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex [4]. " +"2.3.1.35","Also has some hydrolytic activity on acetyl-L-ornithine, but the rate is 1% of that of transferase activity." +"2.3.1.37",A pyridoxal-phosphate protein. The enzyme in erythrocytes is genetically distinct from that in other tissues. +"2.3.1.38","This enzyme, along with EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. The substrate acetyl-CoA protects the enzyme against inhibition by N-ethylmaleimide or iodoacetamide [4]. This is one of the activities associated with beta-ketoacyl-[acyl-carrier-protein] synthase III (EC 2.3.1.180) [5]." +"2.3.1.39","This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis [7]. The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7, holo-[acyl-carrier-protein] synthase) is the preferred substrate [5]. This enzyme also forms part of the multienzyme complexes EC 4.1.1.88, biotin-independent malonate decarboxylase and EC 7.2.4.4, biotin-dependent malonate decarboxylase. Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase [12]. In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot [10] whereas the enzyme from Pseudomonas putida can use both as substrates [11]. The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate cofactor; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA cofactor." +"2.3.1.41","This enzyme is responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain. Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids. The enzyme can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16) [4]. The substrate specificity is very similar to that of EC 2.3.1.179, beta-ketoacyl-ACP synthase II, with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C16Delta9) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature [4,5]. " +"2.3.1.42","A membrane protein. Uses CoA derivatives of palmitate, stearate and oleate, with highest activity on palmitoyl-CoA." +"2.3.1.43","Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC 3.1.1.4 phospholipase A2 and EC 3.1.1.5 lysophospholipase." +"2.3.1.44",Both free and glycosidically bound N-acetyl- and N-glycolyl- neuraminates can act as O-acetyl acceptors. +"2.3.1.45","The enzyme, found in animals, is essential for the formation of acetylated sialoglycans. The acetyl group has been shown to spontaneously move between the 9-O, 8-O, and 7-O positions of the neuraminate, with 9-O acetylation being most favoured." +"2.3.1.47","A pyridoxal-phosphate protein. The enzyme catalyses the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis. Pimeloyl-CoA can be used with lower efficiency [5]." +"2.3.1.48","A group of enzymes acetylating histones. Several of the enzymes can also acetylate lysines in other proteins [3,4]." +"2.3.1.49","Both this enzyme and EC 6.2.1.22, [citrate (pro-3S)-lyase] ligase, acetylate and activate EC 4.1.3.6, citrate (pro-3S)-lyase." +"2.3.1.50",A pyridoxal-phosphate protein. +"2.3.1.51",Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups. +"2.3.1.52",Saturated acyl-CoA thioesters are the most effective acyl donors. +"2.3.1.53","Also acts, more slowly, on L-histidine and L-alanine." +"2.3.1.56",Transfers the N-acetyl group of some aromatic acethydroxamates to the O-position of some aromatic hydroxylamines. +"2.3.1.57","Acts on propane-1,3-diamine, pentane-1,5-diamine, putrescine, spermidine (forming N1- and N8-acetylspermidine), spermine, N1-acetylspermidine and N8-acetylspermidine." +"2.3.1.59","The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors." +"2.3.1.60",Also acetylates sisomicin. +"2.3.1.61","A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A." +"2.3.1.63",May be identical with EC 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase. +"2.3.1.65","Also acts on CoA derivatives of other bile acids. Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly [4]. The enzyme can also conjugate fatty acids to glycine and can act as a very-long-chain acyl-CoA thioesterase [7]. Bile-acid---amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol [4]. This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalysed by EC 6.2.1.7, cholate---CoA ligase." +"2.3.1.66","Propanoyl-CoA can act as a donor, but more slowly. L-Arginine, L-valine, L-phenylalanine and peptides containing L-leucine can act as acceptors." +"2.3.1.68","Phenylacetyl-CoA and (indol-3-yl)acetyl-CoA, but not benzoyl-CoA, can act as acyl donors. Not identical with EC 2.3.1.13 glycine N-acyltransferase or EC 2.3.1.71 glycine N-benzoyltransferase." +"2.3.1.69","(-)-Menthol, (+)-neomenthol, borneol, and also cyclohexanol and decan-1-ol can be acetylated." +"2.3.1.70",Highly specific for both donor and acceptor. +"2.3.1.71","Not identical with EC 2.3.1.13, glycine N-acyltransferase or EC 2.3.1.68, glutamine N-acyltransferase" +"2.3.1.72",The position of acylation is indeterminate because of the ease of acyl transfer between hydroxy groups. +"2.3.1.73","Cholesterol, sitosterol, campesterol and diacylglycerol can act as acceptors. Transfers a number of long-chain fatty acyl groups." +"2.3.1.74","The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin." +"2.3.1.75","The enzyme transfers acyl residues from acyl-CoA to long-chain alcohols, forming wax esters. Wax esters have diverse biological functions in bacteria, insects, mammals, and terrestrial plants. The enzyme from the plant Simmondsia chinensis (jojoba) prefers acyl residues of chain-length C18 to C20 and its preferred acceptor is (11Z)-icos-11-en-1-ol. cf. EC 2.3.1.332, medium-chain-alcohol O-fatty-acyltransferase." +"2.3.1.76",Acts on palmitoyl-CoA and other long-chain fatty-acyl derivatives of CoA. +"2.3.1.77","Tripalmitoylglycerol and, more slowly, other triacylglycerols containing C6 to C22 fatty acids, can act as donors. The best acceptors are 3beta-hydroxysteroids with a planar ring system." +"2.3.1.78",Brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed. Also acts on heparin. Not identical with EC 2.3.1.3 glucosamine N-acetyltransferase or EC 2.3.1.4 glucosamine-phosphate N-acetyltransferase. +"2.3.1.79","Not identical with EC 2.3.1.18, galactoside O-acetyltransferase. The acetyl group is added exclusively to the C6 position of glucose and to the C6 position of the non-reducing glucose residue of maltose [3]. Other substrates of this enzyme are glucose, which is a better substrate than maltose [2], and mannose and frucose, which are poorer substrates than maltose [2]. Isopropyl-beta-thio-galactose, which is a good substrate for EC 2.3.1.118 is a poor substrate for this enzyme [3]." +"2.3.1.80","S-Benzyl-L-cysteine and, in decreasing order of activity, S-butyl-L-cysteine, S-propyl-L-cysteine, O-benzyl-L-serine and S-ethyl-L-cysteine, can act as acceptors." +"2.3.1.81","Different from EC 2.3.1.60 gentamicin 3-N-acetyltransferase. A wide range of antibiotics containing the 2-deoxystreptamine ring can act as acceptors, including gentamicin, kanamycin, tobramycin, neomycin and apramycin." +"2.3.1.82","The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2 and sisomicin are substrates. The antibiotic tobramycin, but not paromomycin, can also act as acceptor. The 6-amino group of the purpurosamine ring is acetylated." +"2.3.1.84","Acts on a range of short-chain aliphatic alcohols, including methanol and ethanol" +"2.3.1.85","The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase system." +"2.3.1.86","The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid-ester dehydrogenase. The enzyme system differs from the animal system (EC 2.3.1.85, fatty-acid synthase system) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid." +"2.3.1.87","Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase." +"2.3.1.88","Acetylates N-terminal alanine, serine, methionine and glutamate residues in a number of peptides and proteins, including beta-endorphin, corticotropins and melanotropin. cf. EC 2.3.1.108 alpha-tubulin N-acetyltransferase." +"2.3.1.90","beta-Glucogallin can act as donor and as acceptor. Digalloylglucose can also act as acceptor, with the formation of 1-O,2-O,6-O-trigalloylglucose" +"2.3.1.93","Benzoyl-CoA and, more slowly, pentanoyl-CoA, 3-methylbutanoyl-CoA and butanoyl-CoA can act as acyl donors. Involved in the synthesis of lupanine alkaloids." +"2.3.1.94","The product, 6-deoxyerythronolide B, contains a 14-membered lactone ring and is an intermediate in the biosynthesis of erythromycin antibiotics. Biosynthesis of 6-deoxyerythronolide B requires 28 active sites that are precisely arranged along three large polypeptides, denoted DEBS1, -2 and -3 [6]. The polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain [5]. Each extension module contains a minimum of a ketosynthase (KS), an acyltransferase (AT) and an acyl-carrier protein (ACP). The KS domain both accepts the growing polyketide chain from the previous module and catalyses the subsequent decarboxylative condensation between this substrate and an ACP-bound methylmalonyl extender unit, introduce by the AT domain. This combined effort gives rise to a new polyketide intermediate that has been extended by two carbon atoms [5]." +"2.3.1.95",Not identical with EC 2.3.1.74 naringenin-chalcone synthase or EC 2.3.1.146 pinosylvin synthase. +"2.3.1.96","Acts on mucins. Activated by 1,4-dithiothreitol." +"2.3.1.97","The enzyme catalyses the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5." +"2.3.1.98","Galactarate can act as acceptor, more slowly. Involved with EC 2.3.1.99 quinate O-hydroxycinnamoyltransferase in the formation of caffeoylglucarate in tomato." +"2.3.1.99","Caffeoyl-CoA and 4-coumaroyl-CoA can also act as donors, but more slowly. Involved in the biosynthesis of chlorogenic acid in sweet potato and, with EC 2.3.1.98 chlorogenate---glucarate O-hydroxycinnamoyltransferase, in the formation of 2-O-caffeoylglucarate in tomato." +"2.3.1.100",The enzyme in brain transfers long-chain acyl residues to the endogenous myelin proteolipid +"2.3.1.101",Methanofuran is a complex 4-substituted furfurylamine and is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum. +"2.3.1.102",Involved in the synthesis of aerobactin from lysine in a strain of Escherichia coli. +"2.3.1.103","The plant enzyme, characterized from Brassicaceae, is involved in secondary metabolism." +"2.3.1.104",Not identical with EC 2.3.1.121 1-alkenylglycerophosphoethanolamine O-acyltransferase. +"2.3.1.105",Involved in the biosynthesis of thrombocyte activating factor in animal tissues. +"2.3.1.106","4-Coumaroyl-CoA (4-hydroxycinnamoyl-CoA), caffeoyl-CoA (3,4-dihydroxycinnamoyl-CoA) and feruloyl-CoA (4-hydroxy-3-methoxycinnamoyl-CoA) can also act as donors for the enzyme from the mung bean (Vigna radiata)." +"2.3.1.107","Catalyses the final step in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus." +"2.3.1.108",The enzyme is conserved from protists to mammals and is present in flowering plants. In most organisms it acetylates L-lysine at position 40 of alpha-tubulin. +"2.3.1.109","Also acts on L-ornithine. This is the first enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [2,6]." +"2.3.1.110","Cinnamoyl-CoA, 4-coumaroyl-CoA and sinapoyl-CoA can also act as donors, and some aromatic amines can act as acceptors." +"2.3.1.111","The enzyme, characterized from mycobacteria, is loaded with a long-chain acyl moiety by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, and elongates it by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8-tetramethyloctacosanoate (C32-mycocerosate). Since the enzyme lacks a thioesterase domain, the product remains bound and requires additional enzyme(s) for removal. Even though the enzyme can accept C6 to C20 substrates in vitro, it prefers to act on C14-C20 substrates in vivo." +"2.3.1.112","1-Aminocyclopropane-1-carboxylate can act instead of malonyl-CoA." +"2.3.1.115","The 6-position of the glucose residue of formononetin can also act as acceptor; some other 7-O-glucosides of isoflavones, flavones and flavonols can also act, but more slowly." +"2.3.1.117","Involved in the biosynthesis of lysine in bacteria (including cyanobacteria) and higher plants. The 1992 edition of the Enzyme List erroneously gave the name 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase to this enzyme." +"2.3.1.118","The enzyme from liver, but not that from bacteria, can also catalyse N-acetylation of arylamines and N,O-acetylation of arylhydroxamates." +"2.3.1.119",Icosanoyl-CoA can act in place of stearoyl-CoA. The membrane enzyme brings about the elongation of these long-chain fatty-acyl-CoAs. +"2.3.1.121",Long-chain unsaturated acyl-CoAs are the best substrates. +"2.3.1.122","Catalyses the exchange of mycolic acid between trehalose, trehalose mycolate and trehalose bismycolate. Trehalose 6-palmitate can also act as donor." +"2.3.1.123","Other acyl-CoAs can also act, but more slowly. alpha-Saturated dolichols are acylated more rapidly than the alpha-unsaturated analogues." +"2.3.1.125",A number of acyl-CoAs can act as acyl donor; maximum activity is obtained with linoleoyl-CoA. Not identical with EC 2.3.1.20 diacylglycerol O-acyltransferase. +"2.3.1.126",Feruloyl-CoA and 4-coumaroyl-CoA can also act as donors. +"2.3.1.128","A group of enzymes in Escherichia coli that acetylate the N-terminal alanine residues of specific ribosomal proteins. cf. EC 2.3.1.88, peptide alpha-N-acetyltransferase." +"2.3.1.129","Involved with EC 2.4.1.182, lipid-A-disaccharide synthase, and EC 2.7.1.130, tetraacyldisaccharide 4'-kinase, in the biosynthesis of the phosphorylated glycolipid, Lipid A, in the outer membrane of Gram-negative bacteria." +"2.3.1.130",Sinapoyl-CoA and 4-coumaroyl-CoA can also act as donors. +"2.3.1.131","4-Coumaroyl-CoA, feruloyl-CoA and caffeoyl-CoA can also act as donors, but more slowly." +"2.3.1.132","4-Coumaroyl-CoA, feruloyl-CoA and caffeoyl-CoA can also act as donors, but more slowly." +"2.3.1.133","Caffeoyl-CoA, feruloyl-CoA and sinapoyl-CoA can also act as donors, but more slowly." +"2.3.1.134",Di-D-galactosyldiacylglycerol can also act as acceptor. +"2.3.1.135","A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol." +"2.3.1.136",Acts only on substrates containing more than 14 sialosyl residues. Catalyses the modification of capsular polysaccharides in some strains of Escherichia coli. +"2.3.1.137","Acts on a range of acyl-CoAs, with optimal activity with C6 or C8 acyl groups. cf. EC 2.3.1.7 (carnitine O-acetyltransferase) and EC 2.3.1.21 (carnitine O-palmitoyltransferase)." +"2.3.1.138","Feruloyl-CoA, cinnamoyl-CoA and sinapoyl-CoA can also act as donors, but more slowly." +"2.3.1.140","Involved, with EC 1.1.1.237 (hydroxyphenylpyruvate reductase) in the biosynthesis of rosmarinic acid. Characterized from the plant Melissa officinalis L. (lemon balm)." +"2.3.1.141",Transfers long-chain acyl groups to the sn-1 position of the glycerol residue. +"2.3.1.144","Cinnamoyl-CoA, 4-coumaroyl-CoA and salicyloyl-CoA can act as donors, but more slowly. Involved in the biosynthesis of phytoalexins." +"2.3.1.145","Pyrrolidine and 3-pyrroline can also act as acceptors, but more slowly." +"2.3.1.146",Not identical with EC 2.3.1.74 (naringenin-chalcone synthase) or EC 2.3.1.95 (trihydroxystilbene synthase). +"2.3.1.147","Catalyses the transfer of arachidonate and other polyenoic fatty acids from intact choline or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.148 glycerophospholipid acyltransferase (CoA-dependent) in not requiring CoA and in its specificity for poly-unsaturated acyl groups." +"2.3.1.148","Catalyses the transfer of fatty acids from intact choline- or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent) in requiring CoA and not favouring the transfer of polyunsaturated acyl groups." +"2.3.1.149","Catalyses the transfer of the acetyl group from 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the sn-2 position of lyso-glycerophospholipids containing ethanolamine, choline, serine, inositol or phosphate groups at the sn-3 position as well as to sphingosine and long-chain fatty alcohols. The organyl group can be alkyl, acyl or alk-1-enyl (sometimes also collectively referred to as 'radyl')." +"2.3.1.150","The enzyme is present in the poppy, Papaver somniferum. At pH 8-9 the product, 7-O-acetylsalutaridinol, spontaneously closes the 4->5 oxide bridge by allylic elimination to form the morphine precursor thebaine" +"2.3.1.151","Involved in the biosynthesis of plant xanthones. Benzoyl-CoA can replace 3-hydroxybenzoyl-CoA (cf. EC 2.3.1.220, 2,4,6-trihydroxybenzophenone synthase)." +"2.3.1.152","Acceptor alcohols (ROH) include methanol, ethanol and propanol. No cofactors are required as 1-O-trans-cinnamoyl-beta-D-glucopyranose itself is an ""energy-rich"" (activated) acyl-donor, comparable to CoA-thioesters. 1-O-trans-Cinnamoyl-beta-D-gentobiose can also act as the acyl donor, but with much less affinity." +"2.3.1.153","Isolated from the plant Gentiana triflora. Transfers the hydroxycinnamoyl group only to the C-5 glucoside of anthocyanin. Caffeoyl-CoA, but not malonyl-CoA, can substitute as an acyl donor." +"2.3.1.154","The peroxisomal protein sterol carrier protein X (SCPx) combines this thiolase activity with its carrier function, and is involved in branched chain fatty acid beta-oxidation in peroxisomes. It also acts on 3-oxopalmitoyl-CoA as a substrate but differs from EC 2.3.1.16 (acetyl-CoA C-acyltransferase), which has little activity towards the 3-oxoacyl-CoA esters of 2-methyl-branched chain fatty acids such as 3-oxopristanoyl-CoA." +"2.3.1.155",A peroxisomal enzyme involved in branched chain fatty acid beta-oxidation in peroxisomes. It differs from EC 2.3.1.176 (propanoyl-CoA C-acyltransferase) in not being active towards 3-oxopristanoyl-CoA. +"2.3.1.156","Closely related to EC 2.3.1.74, naringenin-chalcone synthase. Also acts on isobutyryl-CoA as substrate to give phlorisobutyrophenone. The products are intermediates in the biosynthesis of the bitter acids in hops (Humulus lupulus) and glucosides in strawberry (Fragaria X ananassa). It is also able to generate naringenin chalcone from 4-coumaroyl-CoA." +"2.3.1.157","The enzyme from several bacteria (e.g., Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase." +"2.3.1.158","This enzyme differs from EC 2.3.1.20, diacylglycerol O-acyltransferase, by synthesising triacylglycerol using an acyl-CoA-independent mechanism. The specificity of the enzyme for the acyl group in the phospholipid varies with species, e.g., the enzyme from castor bean (Ricinus communis) preferentially incorporates vernoloyl (12,13-epoxyoctadec-9-enoyl) groups into triacylglycerol, whereas that from the hawk's beard (Crepis palaestina) incorporates both ricinoleoyl (12-hydroxyoctadec-9-enoyl) and vernoloyl groups. The enzyme from the yeast Saccharomyces cerevisiae specifically transfers acyl groups from the sn-2 position of the phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid." +"2.3.1.159","Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)" +"2.3.1.160","The reaction proceeds in two stages. The indole nitrogen of 16-epivellosimine interacts with its aldehyde group giving an hydroxy-substituted new ring. This alcohol is then acetylated. Also acts on gardneral (11-methoxy-16-epivellosimine). Generates the ajmalan skeleton, which forms part of the route to ajmaline." +"2.3.1.161","This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase. The PKS catalyses many of the chain building reactions of EC 2.3.1.85, fatty-acid synthase system, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production." +"2.3.1.162","This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas." +"2.3.1.163","Acts on a number of related taxane diterpenoids with a free 10beta-hydroxy group. May be identical to EC 2.3.1.167, 10-deacetylbaccatin III 10-O-acetyltransferase." +"2.3.1.164","Proceeds by a two stage mechanism via 6-aminopenicillanic acid. Different from EC 3.5.1.11, penicillin amidase." +"2.3.1.165",A multienzyme complex with a tightly-bound 4'-phosphopantetheine cofactor on the acyl carrier protein. It has a similar sequence to vertebrate type I fatty acid synthase. Acetoacetyl-CoA can also act as a starter molecule. +"2.3.1.166","The enzyme was studied using the semisynthetic substrate 2-debenzoyl-7,13-diacetylbaccatin III. It will not acylate the hydroxy group at 1beta, 7beta, 10beta or 13alpha of 10-deacetyl baccatin III, or at 2alpha or 5alpha of taxa-4(20),11-diene-2alpha,5alpha-diol." +"2.3.1.167","The enzyme will not acylate the hydroxy group at 1beta, 7beta or 13alpha of 10-deacetyl baccatin III, or at 5alpha of taxa-4(20),11-dien-5alpha-ol. May be identical to EC 2.3.1.163, 10-hydroxytaxane O-acetyltransferase." +"2.3.1.168","A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC 1.2.4.4, and the only observed direction catalysed by EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to coenzyme A. In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC 1.2.4.4 acts on the oxo acids corresponding with leucine and isoleucine." +"2.3.1.169","Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2." +"2.3.1.247","Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). It is involved in the anaerobic fermentation of lysine. cf. EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase." +"2.3.1.170","Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone." +"2.3.1.171","Acts on pelargonidin 3-O-glucoside in dahlia (Dahlia variabilis), delphinidin 3-O-glucoside, and on cyanidin 3-O-glucoside in transgenic petunia (Petunia hybrida)." +"2.3.1.172","Specific for the penultimate step in salvianin biosynthesis. The enzyme also catalyses the malonylation of shisonin to malonylshisonin [cyanidin 3-O-(6''-O-p-coumaryl-beta-D-glucoside)-5-(6'''-O-malonyl-beta-D-glucoside)]. The compounds 4'''-demalonylsalvianin, salvianin, pelargonidin 3,5-diglucoside and delphinidin 3,5-diglucoside cannot act as substrates." +"2.3.1.173","Acylates kaempferol 3-O-triglucoside on the terminal glucosyl unit, almost certainly at C-6." +"2.3.1.174","The enzyme from the bacterium Escherichia coli also has the activity of EC 2.3.1.223 (3-oxo-5,6-dehydrosuberyl-CoA thiolase)." +"2.3.1.175",This enzyme catalyses the final step in the biosynthesis of cephalosporin C. +"2.3.1.176","Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [3]." +"2.3.2.1","The enzyme catalyses two reactions. The first is the transfer of a glutamyl residue from L- or D-glutamine to D-glutamate via a gamma linkage, forming gamma-glutamyl-D-glutamate, and the second is the transfer of additional glutamyl residues to the peptide, extending the polypeptide chain." +"2.3.2.2","The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4]." +"2.3.2.4","The enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine." +"2.3.2.5",Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA. +"2.3.2.6","Requires a univalent cation. The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-arginine or L-lysine residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. The enzyme also transfers L-phenylalanine in vitro, but this has not been observed in vivo [5]. cf. EC 2.3.2.29, aspartate/glutamate leucyltransferase, and EC 2.3.2.8, arginyltransferase." +"2.3.2.8","Requires 2-sulfanylethan-1-ol (2-mercaptoethanol) and a univalent cation. Peptides and proteins containing an N-terminal glutamate, aspartate or cystine residue can act as acceptors." +"2.3.2.9","4-Hydroxyaniline, cyclohexylamine, 1-naphthylhydrazine and similar compounds can act as acceptors; the enzyme also catalyses the hydrolysis of agaritine." +"2.3.2.10",Also acts on L-seryl-tRNASer. +"2.3.2.12","The enzyme is a ribozyme. Two non-equivlant ribonucleoprotein subunits operate in non-concerted fashion in peptide elongation. The small subunit forms the mRNA-binding machinery and decoding center, the large subunit performs the main ribosomal catalytic function in the peptidyl-transferase center." +"2.3.2.13","Requires Ca2+. The gamma-carboxamide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N6-(5-glutamyl)-lysine crosslinks. Formed by proteolytic cleavage from plasma Factor XIII" +"2.3.2.14","D-Phenylalanine and D-2-aminobutyrate can also act as acceptors, but more slowly. The enzyme also catalyses some of the reactions of EC 2.3.2.2 (gamma-glutamyltransferase)." +"2.3.3.1","The stereospecificity of this enzyme is opposite to that of EC 2.3.3.3, citrate (Re)-synthase, which is found in some anaerobes. Citrate synthase for which the stereospecificity with respect to C-2 of oxaloacetate has not been established are included in EC 2.3.3.16, citrate synthase (unknown stereospecificity). " +"2.3.3.16","This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C-2 of oxaloacetate has not been established [cf. EC 2.3.3.1, citrate (Si)-synthase and EC 2.3.3.3, citrate (Re)-synthase]." +"2.3.3.3","This enzyme is inactivated by oxygen and is found in some anaerobes. Its stereospecificity is opposite to that of EC 2.3.3.1, citrate (Si)-synthase." +"2.3.3.4","Decanoyl-CoA can act instead of dodecanoyl-CoA, but 2-oxoglutarate cannot be replaced by oxaloacetate or pyruvate." +"2.3.3.5","The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1, citrate (Si)-synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate." +"2.3.3.6",Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included with EC 2.3.3.7 3-ethylmalate synthase. +"2.3.3.8","The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase)." +"2.3.3.9","The enzyme catalyses the irreversible condensation of acetyl-CoA with glyoxylate to form (S)-malate. Among other functions, the enzyme participates in the glyoxylate cycle, a modified version of the TCA cycle that bypasses steps that lead to a loss of CO2." +"2.3.3.13",Requires K+. +"2.3.3.14","Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36, homoaconitate hydratase. The enzyme also acts with oxaloacetate as substrate, but more slowly [2,3]. " +"2.3.3.15",The reaction occurs in the reverse direction to that shown above. Requires Mg2+. +"2.4.1.1","This entry covers several enzymes from different sources that act in vivo on different forms of (1->4)-alpha-D-glucans. Some of these enzymes catalyse the first step in the degradation of large branched glycan polymers - the phosphorolytic cleavage of alpha-1,4-glucosidic bonds from the non-reducing ends of linear poly(1->4)-alpha-D-glucosyl chains within the polymers. The enzyme stops when it reaches the fourth residue away from an alpha-1,6 branching point, leaving a highly branched core known as a limit dextrin. The accepted name of the enzyme should be modified for each specific instance by substituting ""glycogen"" with the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, etc." +"2.4.1.4","The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends the glucan chain by an alpha(1->4) linkage." +"2.4.1.5","The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends the glucan chain by an alpha(1->6) linkage." +"2.4.1.7","In the forward reaction, arsenate may replace phosphate. In the reverse reaction, various ketoses and L-arabinose may replace D-fructose." +"2.4.1.9",Converts sucrose into inulin and D-glucose. Some other sugars can act as D-fructosyl acceptors. +"2.4.1.10",Some other sugars can act as D-fructosyl acceptors. +"2.4.1.11","The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, glycogen phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose [EC 2.4.1.21, starch synthase (glycosyl-transferring)]." +"2.4.1.12",Involved in the synthesis of cellulose. A similar enzyme utilizes GDP-glucose [EC 2.4.1.29 cellulose synthase (GDP-forming)]. +"2.4.1.13","Although UDP is generally considered to be the preferred nucleoside diphosphate for sucrose synthase, numerous studies have shown that ADP serves as an effective acceptor molecule to produce ADP-glucose [3-9]. Sucrose synthase has a dual role in producing both UDP-glucose (necessary for cell wall and glycoprotein biosynthesis) and ADP-glucose (necessary for starch biosynthesis) [10]." +"2.4.1.14","Requires Mg2+ or Mn2+ for maximal activity [2]. The enzyme from Synechocystis sp. strain PCC 6803 is not specific for UDP-glucose as it can use ADP-glucose and, to a lesser extent, GDP-glucose as substrates [2]. The enzyme from rice leaves is activated by glucose 6-phosphate but that from cyanobacterial species is not [2]. While the reaction catalysed by this enzyme is reversible, the enzyme usually works in concert with EC 3.1.3.24, sucrose-phosphate phosphatase, to form sucrose, making the above reaction essentially irreversible [3]. The F in sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent." +"2.4.1.15","See also EC 2.4.1.36 [alpha,alpha-trehalose-phosphate synthase (GDP-forming)]." +"2.4.1.16",Converts UDP-N-acetyl-alpha-D-glucosamine into chitin and UDP. +"2.4.1.17","This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1." +"2.4.1.18","Converts amylose into amylopectin. The accepted name requires a qualification depending on the product, glycogen or amylopectin, e.g. glycogen branching enzyme, amylopectin branching enzyme. The latter has frequently been termed Q-enzyme." +"2.4.1.19","Cyclomaltodextrins (Schardinger dextrins) of various sizes (6,7,8, etc. glucose units) are formed reversibly from starch and similar substrates. Will also disproportionate linear maltodextrins without cyclizing (cf. EC 2.4.1.25, 4-alpha-glucanotransferase)." +"2.4.1.21","The accepted name varies according to the source of the enzyme and the nature of its synthetic product, e.g. starch synthase, bacterial glycogen synthase. Similar to EC 2.4.1.11 [glycogen(starch) synthase] but the preferred or mandatory nucleoside diphosphate sugar substrate is ADP-alpha-D-glucose. The entry covers starch and glycogen synthases utilizing ADP-alpha-D-glucose." +"2.4.1.22","The enzyme is a complex of two proteins, A and B. In the absence of the B protein (alpha-lactalbumin), the enzyme catalyses the transfer of galactose from UDP-alpha-D-galactose to N-acetylglucosamine (EC 2.4.1.90 N-acetyllactosamine synthase)." +"2.4.1.25","This entry covers the former separate entry for EC 2.4.1.3 (amylomaltase). The plant enzyme has been termed D-enzyme. An enzymic activity of this nature forms part of the mammalian and yeast glycogen debranching system (see EC 3.2.1.33 amylo-alpha-1,6-glucosidase)." +"2.4.1.29","Involved in the synthesis of cellulose. A similar enzyme [EC 2.4.1.12, cellulose synthase (UDP-forming)] utilizes UDP-alpha-D-glucose." +"2.4.1.30","Does not act on laminarin. Differs in specificity from EC 2.4.1.31 (laminaribiose phosphorylase) and EC 2.4.1.97 (1,3-beta-D-glucan phosphorylase)." +"2.4.1.31","Also acts on 1,3-beta-D-oligoglucans. Differs in specificity from EC 2.4.1.30 (1,3-beta-oligoglucan phosphorylase) and EC 2.4.1.97 (1,3-beta-D-glucan phosphorylase)." +"2.4.1.33","The enzyme catalyses the polymerization of beta-D-mannuronate residues into a mannuronan polymer, an intermediate in the biosynthesis of alginate. It is found in brown algae and in alginate-producing bacterial species from the Pseudomonas and Azotobacter genera." +"2.4.1.35",Acts on a wide range of phenols. +"2.4.1.36","See also EC 2.4.1.15 [alpha,alpha-trehalose-phosphate synthase (UDP-forming)]." +"2.4.1.37","Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors." +"2.4.1.38","Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. High activity is shown towards such residues in branched-chain polysaccharides when these are linked by beta-1,6-links to galactose residues; lower activity towards residues linked to galactose by beta-1,3-links. A component of EC 2.4.1.22 (lactose synthase)." +"2.4.1.40","Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors." +"2.4.1.41","Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass." +"2.4.1.44","Transfers alpha-D-galactosyl residues to D-glucose in the partially completed core of lipopolysaccharide [cf. EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase), EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)]." +"2.4.1.45",Highly specific. +"2.4.1.46","This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4]." +"2.4.1.47","This membrane-bound, endoplasmic reticulum-located enzyme catalyses the last step in the synthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. It has a strong preference for ceramides that contain hydroxylated fatty acids." +"2.4.1.48","The acceptor is a heteroglycan primer containing mannose, galactose and xylose. 1,2- and 1,3-mannosyl bonds are formed." +"2.4.1.50",Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.66 procollagen glucosyltransferase). +"2.4.1.52","Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme, isolated from Bacillus subtilis 168, adds an alpha-D-glucose to the free OH groups of the glycerol units. The enzyme has a strong preference for UDP-alpha-glucose as the sugar donor. It has no activity with poly(ribitol phosphate). " +"2.4.1.53",Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Bacillus subtilis W23. This enzyme adds a beta-D-glucose to the hydroxyl group at the 2 position of the ribitol phosphate units. +"2.4.1.54",Requires phosphatidylglycerol. +"2.4.1.56","Transfers N-acetylglucosaminyl residues to a D-galactose residue in the partially completed lipopolysaccharide core [cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase), EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)]." +"2.4.1.58","Transfers glucosyl residues to the backbone portion of lipopolysaccharide [cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase, EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase) and EC 2.4.1.73 (lipopolysaccharide glucosyltransferase II)]." +"2.4.1.60","The enzyme from Salmonella participates in the biosynthesis of the repeat unit of O antigens produced by strains that belong to the A, B and D1-D3 groups. The enzyme is able to transfer abequose, paratose, or tyvelose, depending on the availability of the specific dideoxyhexose in a particular strain." +"2.4.1.62","The substrate is also known as gangloside GM2, the product as gangloside GM1a" +"2.4.1.63",The enzyme glucosylates the cyanohydrins of butanone and pentan-3-one as well as that of acetone. +"2.4.1.65","This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-alpha-fucosylation of the GlcNAc in beta-D-Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities." +"2.4.1.66",Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.50 procollagen galactosyltransferase). +"2.4.1.67","This enzyme also catalyses galactosyl transfer from stachyose to raffinose (shown by labelling) [4]. For synthesis of the substrate, see EC 2.4.1.123, inositol 3-alpha-galactosyltransferase. See also EC 2.4.1.82, galactinol---sucrose galactosyltransferase." +"2.4.1.68","This enzyme catalyses a reaction similar to that of EC 2.4.1.214, glycoprotein 3-alpha-L-fucosyltransferase, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage rather than an alpha1,3-linkage." +"2.4.1.69","The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 1 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen. In humans the main enzyme performing this reaction is encoded by the FUT2 gene (also known as the Secretor gene), which is also able to act on type 2 substrates (see EC 2.4.1.344). The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates." +"2.4.1.70",Involved in the biosynthesis of poly(ribitol phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-alpha-D-glucosamine to the hydroxyl group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.355 [poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase]. +"2.4.1.73","Transfers glucosyl residues to the D-galactosyl-D-glucosyl side-chains in the partially completed core of lipopolysaccharides. cf. EC 2.4.1.44 (lipopolysaccharide 3-alpha-galactosyltransferase), EC 2.4.1.56 (lipopolysaccharide N-acetylglucosaminyltransferase) and EC 2.4.1.58 (lipopolysaccharide glucosyltransferase I)." +"2.4.1.74",Involved in the biosynthesis of galactose-containing glycosaminoglycan of the ameboid protozoan Dictyostelium discoideum. +"2.4.1.78","Ficaprenyl phosphate is the best substrate; other polyprenols can also act as substrates, but more slowly." +"2.4.1.79","Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}." +"2.4.1.80",Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor. +"2.4.1.81","A number of flavones, flavanones and flavonols can function as acceptors. Different from EC 2.4.1.91 (flavonol 3-O-glucosyltransferase)." +"2.4.1.82","4-Nitrophenyl alpha-D-galactopyranoside can also act as donor. The enzyme also catalyses an exchange reaction between raffinose and sucrose (cf. EC 2.4.1.123, inositol 3-alpha-galactosyltransferase)." +"2.4.1.83",Acts only on long-chain polyprenyl phosphates and alpha-dihydropolyprenyl phosphates that are larger than C35. +"2.4.1.85","Acts on a wide range of substrates in vitro, including cyanohydrins, terpenoids, phenolics, hexanol derivatives and plant hormones, in a regiospecific manner [3]. This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.14.36, tyrosine N-monooxygenase and EC 1.14.14.37, 4-hydroxyphenylacetaldehyde oxime monooxygenase. This reaction prevents the disocciation and release of toxic hydrogen cyanide [3]." +"2.4.1.86","The enzyme transfers galactose from UDP-alpha-D-galactose to the 3-position of substrates with a non-reducing terminal N-acetyl-beta-D-glucosamine (beta-GlcNAc) residue. It can act on both glycolipids and glycoproteins, generating a structure known as the type 1 histo-blood group antigen precursor. " +"2.4.1.345","Requires Mg2+. The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). " +"2.4.1.87","Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151." +"2.4.1.90","The reaction is catalysed by a component of EC 2.4.1.22 (lactose synthase), which is identical with EC 2.4.1.38 (beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase), and by an enzyme from the Golgi apparatus of animal tissues. Formerly listed also as EC 2.4.1.98." +"2.4.1.91","Acts on a variety of flavonols, including quercetin and quercetin 7-O-glucoside. Different from EC 2.4.1.81 (flavone 7-O-beta-glucosyltransferase)." +"2.4.1.92","This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. Asialo-GM3 [3] and lactosylceramide [2] are also substrates, but glycoproteins and oligosaccharides are not substrates." +"2.4.1.94",The acceptor is the asparagine residue in a sequence of the form Asn-Xaa-Thr or Asn-Xaa-Ser. +"2.4.1.96","The product is hydrolysed by a phosphatase to isofloridoside, which is involved in osmoregulation (cf. EC 2.4.1.137 sn-glycerol-3-phosphate 2-alpha-galactosyltransferase)." +"2.4.1.97","Acts on a range of beta-1,3-oligoglucans, and on glucans of laminarin type. Different from EC 2.4.1.30 (1,3-beta-oligoglucan phosphorylase) and EC 2.4.1.31 (laminaribiose phosphorylase)." +"2.4.1.99","For definition of the prime in the systematic name, see 2-Carb-36.2." +"2.4.1.101","The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. Its action is required before the other N-acetylglucosaminyltransferases involved in the process (GlcNAcT-II through VI) can act. While the natural substrate (produced by EC 3.2.1.113, mannosyl-oligosaccharide 1,2-alpha-mannosidase) is described here, the minimal substrate recognized by the enzyme is alpha-D-Man-(1->3)-beta-D-Man-R." +"2.4.1.102",The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2. +"2.4.1.103","Acts on other hydroxy- and dihydroxy-derivatives of 9,10-anthraquinone." +"2.4.1.104","Converts the aglycone daphetin into daphnin and, more slowly, esculetin into cichoriin, umbelliferone into skimmin, hydrangetin into hydrangin and scopoletin into scopolin." +"2.4.1.105",Vitexin is a flavonoid from Cannabis sativa (hemp) and some populations of Silene alba. +"2.4.1.106",Isovitexin is a flavonoid from petals of Silene alba. +"2.4.1.109","The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain alpha-dihydropolyprenyl derivatives, larger than C35." +"2.4.1.110","This enzyme, found in higher vertebrates, modifies tRNAAsp at the wobble position of the anticodon loop. " +"2.4.1.111",Sinapyl alcohol can also act as acceptor. +"2.4.1.112","The enzyme builds up alpha-1,4-glucan chains covalently bound to protein, thus acting as an initiator of glycogen synthesis." +"2.4.1.113","The enzyme builds up alpha-1,4-glucan chains covalently bound to protein, thus acting as an initiator of glycogen synthesis." +"2.4.1.114",Coumarinate (cis-2-hydroxycinnamate) does not act as acceptor. +"2.4.1.115","The anthocyanidin compounds cyanidin, delphinidin, peonidin and to a lesser extent pelargonidin can act as substrates. The enzyme does not catalyse glucosylation of the 5-position of cyanidin and does not act on flavanols such as quercetin and kaempferol (cf. EC 2.4.1.91 flavonol 3-O-glucosyltransferase). In conjunction with EC 1.14.20.4, anthocyanidin synthase, it is involved in the conversion of leucoanthocyanidin into anthocyanidin 3-glucoside. It may act on the pseudobase precursor of the anthocyanidin rather than on the anthocyanidin itself [3]." +"2.4.1.116","Isolated from the plants Silene dioica (red campion) [1], Iris ensata (Japanese iris) [2] and Iris hollandica (Dutch iris) [3]. Also acts on the 3-O-rutinosides of pelargonidin, delphinidin and malvidin, but not the corresponding glucosides or 6-acylglucosides. The enzyme does not catalyse the glucosylation of the 5-hydroxy group of cyanidin 3-glucoside." +"2.4.1.117","Solanesyl phosphate and ficaprenyl phosphate can act as acceptors, but more slowly." +"2.4.1.118","Acts on a range of N6-substituted adenines, including zeatin and N6-benzylaminopurine, but not N6-benzyladenine. With some acceptors, 9-beta-D-glucosides are also formed." +"2.4.1.119",Transfers the glucosyl-mannosyl-glucosamine polysaccharide side-chains of glycoproteins to an asparagine residue in the sequence Asn-Xaa-Ser or Asn-Xaa-Thr in the nascent polypeptide chains of the protein moiety. +"2.4.1.120","Some other hydroxycinnamates, including 4-coumarate, ferulate and caffeate, can act as acceptors, but more slowly. Only glucose esters, not glucosides, are formed (cf. EC 2.4.1.126 hydroxycinnamate 4-beta-glucosyltransferase)." +"2.4.1.122","The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T antigen. The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit." +"2.4.1.123",An enzyme from plants involved in the formation of raffinose and stachyose [cf. EC 2.4.1.67 (galactinol---raffinose galactosyltransferase) and EC 2.4.1.82 (galactinol---sucrose galactosyltransferase)]. +"2.4.1.125","The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends (1->6)-alpha-D-glucans by both alpha(1->3) and alpha(1->6) linkages, with one of the linkage types being dominant. cf. EC 2.4.1.140, alternansucrase." +"2.4.1.126","Acts on 4-coumarate, ferulate, caffeate and sinapate, forming a mixture of 4-glucosides and glucose esters (cf. EC 2.4.1.120 sinapate 1-glucosyltransferase)." +"2.4.1.127",(+)-Neomenthol can also act as acceptor. +"2.4.1.129","The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here). Involved in the synthesis of cell-wall peptidoglycan." +"2.4.1.394","The enzyme, originally discovered in lactic acid bacteria but later found in other organisms, is similar to EC 2.4.1.395, reuteransucrase, yet is not able to act on sucrose. The enzyme, which belongs to the glycoside hydrolase 70 (GH70) family, possesses both hydrolase and transglycosylase activities, cleaving alpha(1->4) linkages from the non-reducing end of linear maltooligosaccharides and synthesizing linear alpha(1->6)-glucan chains. It also possesses an endo-alpha(1->4)-glycosidase activity. Due to its narrow binding groove, it is not able to act on branched substrates. cf. EC 2.4.1.396, 4,6-alpha-glucanotransferase (linear and branched substrates, branched products)." +"2.4.1.130",Four of the nine mannosyl residues in the main membrane lipid-linked oligosaccharide of the structure Glc3Man9GlcNAc2 are produced by the action of this enzyme. +"2.4.1.131","The biosynthesis of asparagine-linked glycoproteins (N-linked protein glycosylation) utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. ALG11 mannosyltransferase from Saccharomyces cerevisiae carries out two sequential steps in the formation of the lipid-linked core oligosaccharide, adding two mannose residues in alpha(1->2) linkages to the nascent oligosaccharide." +"2.4.1.132","The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha1,3-mannosylation of D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol, followed by an alpha1,6-mannosylation (cf. EC 2.4.1.257), to form the first branched pentasaccharide intermediate of the dolichol pathway [1,2]. " +"2.4.1.133","Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+." +"2.4.1.134","Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+." +"2.4.1.135","Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+." +"2.4.1.136","A number of substituted benzoic acids and, more slowly, cinnamic acids, can act as acceptors. Vanillin is the best acceptor investigated." +"2.4.1.137",The product is hydrolysed by a phosphatase to floridoside (cf. EC 2.4.1.96 sn-glycerol-3-phosphate 1-galactosyltransferase). +"2.4.1.139",Neither free phosphate nor maltose 1-phosphate is an intermediate in the reaction. +"2.4.1.140","The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme forms both alpha(1->3) and alpha(1->6) linkages in approximately equal amounts by alternating the linkage type. cf. EC 2.4.1.125, sucrose---1,6-alpha-glucan 3(6)-alpha-glucosyltransferase." +"2.4.1.143","The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. Its activity initiates the synthesis of the second antenna of di-antennary complex N-glycans. While the natural substrate (produced by EC 3.2.1.114, mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) is described here, the minimal substrate recognized by the enzyme is alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-R." +"2.4.1.144","The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. The residue added by the enzyme at position 4 of the beta-linked mannose of the trimannosyl core of N-glycans is known as a bisecting GlcNAc. Unlike GlcNAc residues added to other positions, it is not extended or modified. In addition, its presence prevents the action of other branching enzymes involved in the process such as GlcNAc-T IV (EC 2.4.1.145) and GlcNAc-T V (EC 2.4.1.155), and thus increased activity of GlcNAc-T III leads to a decrease in highly branched N-glycan structures." +"2.4.1.145","Requires Mn2+. The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. By adding a glucosaminyl residue to biantennary N-linked glycans, it enables the synthesis of tri- and tetra-antennary complexes." +"2.4.1.146",The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans. +"2.4.1.147","The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans. O-Linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue." +"2.4.1.148","cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase)." +"2.4.1.149","Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on glycoproteins, glycolipids, and oligosaccharides." +"2.4.1.150","The enzyme acts on poly-N-acetyllactosamine [glycan chains of beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine units connected by beta(1,3) linkages] attached to proteins or lipids. It transfers a GlcNAc residue by beta(1,6)-linkage to galactosyl residues close to non-reducing terminals, introducing a branching pattern known as I branching." +"2.4.1.152","Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3." +"2.4.1.153","The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, initiates N-linked glycosylation in that organism. The enzyme differs from the eukaryotic enzyme, which leaves one additional phosphate group on the dolichyl product (cf. EC 2.7.8.15, UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminephosphotransferase)." +"2.4.1.154",The enzyme is highly acceptor-specific; it does not act on globotetraosylceramide or lactosylceramide. The product has a terminal beta-N-acetylgalactosamine residue. +"2.4.1.155","Requires Mg2+. The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. It catalyses the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides, and thus enables the synthesis of tri- and tetra-antennary complexes." +"2.4.1.157","The enzyme from the bacterium Acholeplasma laidlawii, which lacks a celll wall, produces the major non-bilayer lipid in the organism. The enzyme from the bacterium Agrobacterium tumefaciens acts under phosphate deprivation, generating glycolipids as surrogates for phospholipids. The enzyme belongs to the GT4 family of configuration-retaining glycosyltransferases. Many diacylglycerols with long-chain acyl groups can act as acceptors. cf. EC 2.4.1.336, monoglucosyldiacylglycerol synthase." +"2.4.1.158","13-beta-D-Glucosyloxydocosanoate can also act as acceptor, leading to the formation by Candida bogoriensis of the extracellular glycolipid, hydroxydocosanoate sophoroside diacetate." +"2.4.1.159","A configuration-inverting rhamnosyltransferase that converts flavonol 3-O-glucosides to 3-O-rutinosides. Also acts, more slowly, on rutin, quercetin 3-O-galactoside and flavonol 3-O-rhamnosides." +"2.4.1.160","4'-Deoxypyridoxine and pyridoxamine can also act as acceptors, but more slowly." +"2.4.1.161","The enzyme acts on amylose, amylopectin, glycogen and maltooligosaccharides. No detectable free glucose is formed, indicating the enzyme does not act as a hydrolase. The enzyme from the bacterium Cellvibrio japonicus has the highest activity with maltotriose as a donor, and also accepts maltose [3], while the enzyme from amoeba does not accept maltose [1,2]. Oligosaccharides with 1->6 linkages cannot function as donors, but can act as acceptors [3]. Unlike EC 2.4.1.25, 4-alpha-glucanotransferase, this enzyme can transfer only a single glucosyl residue. " +"2.4.1.163",Requires Mn2+. +"2.4.1.164",Requires Mn2+. +"2.4.1.165","Requires Mn2+. The enzyme, found in mammals, is only active with substrates containing (2->3) linked sialic acid residues [2,3]. It is active with glycoproteins, but not with gangliosides. The enzyme is involved in synthesis of the blood group antigen Sda." +"2.4.1.166",The 3F position of raffinose can also act as galactosyl acceptor; the enzyme is involved in the accumulation of the tetrasaccharides lychnose and isolychnose in the leaves of Cerastium arvense and other plants of the family Caryophyllaceae during late autumn. +"2.4.1.167",The enzyme is involved in the synthesis of the trisaccharide planteose and higher analogues in the seeds of Plantago and Sesamum species. +"2.4.1.168","In association with EC 2.4.2.39 (xyloglucan 6-xylosyltransferase), this enzyme brings about the synthesis of xyloglucan; concurrent transfers of glucose and xylose are essential for this synthesis. Not identical with EC 2.4.1.12 cellulose synthase (UDP-forming)." +"2.4.1.170","The 4'-methoxy isoflavones biochanin A and formononetin and, more slowly, the 4'-hydroxyisoflavones genistein and daidzein, can act as acceptors. The enzyme does not act on isoflavanones, flavones, flavanones, flavanols or coumarins." +"2.4.1.171","Brings about the biosynthesis of the toxic substance cycasin in the leaves of Japanese cycad, Cycas revoluta. " +"2.4.1.173",Not identical with EC 2.4.1.192 (nuatigenin 3beta-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3beta-glucosyltransferase). +"2.4.1.174","Requires Mn2+. Involved in the biosynthesis of chondroitin sulfate. Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core." +"2.4.1.175","Involved in the biosynthesis of chondroitin sulfate. The human form of this enzyme is a bifunctional glycosyltransferase, which also has the 3-beta-glucuronosyltransferase (EC 2.4.1.226, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) activity required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli." +"2.4.1.176",Acts on the plant hormone gibberellin GA3 and related compounds. +"2.4.1.177","4-Coumarate, 2-coumarate, benzoate, feruloate and caffeate can also act as acceptors, but more slowly. Involved in the biosynthesis of chlorogenic acid in the root of the sweet potato, Ipomoea batatas. " +"2.4.1.178","3,4-Dihydroxymandelonitrile can also act as acceptor." +"2.4.1.179","R may be an oligosaccharide or a glycolipid; lactose can also act as acceptor, but more slowly. Involved in the elongation of oligosaccharide chains, especially in glycolipids." +"2.4.1.180",Involved in the biosynthesis of common antigen in Enterobacteriaceae. +"2.4.1.181","A range of anthraquinones and some flavones can act as acceptors; best substrates are emodin, anthrapurpurin, quinizarin, 2,6-dihydroanthraquinone and 1,8-dihydroxyanthraquinone." +"2.4.1.182","Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria. " +"2.4.1.183","A glucan primer is needed to begin the reaction, which brings about elongation of the glucan chains." +"2.4.1.184","The enzyme converts monogalactosyldiacylglycerol to digalactosyldiacylglycerol, trigalactosyldiacylglycerol and tetragalactosyldiacylglycerol. All residues are connected by beta linkages. The activity is localized to chloroplast envelope membranes, but it does not contribute to net galactolipid synthesis in plants, which is performed by EC 2.4.1.46, monogalactosyldiacylglycerol synthase, and EC 2.4.1.241, digalactosyldiacylglycerol synthase. Note that the beta,beta-digalactosyldiacylglycerol formed by this enzyme is different from the more common alpha,beta-digalactosyldiacylglycerol formed by EC 2.4.1.241. The enzyme provides an important mechanism for the stabilization of the chloroplast membranes during freezing and drought stress." +"2.4.1.185",Naringenin and hesperetin can act as acceptors. No action on flavones or flavonols. +"2.4.1.186","The first reaction of this enzyme is to catalyse its own glucosylation, normally at Tyr-194 of the protein if this group is free. When Tyr-194 is replaced by Thr or Phe, the enzyme's Mn2+-dependent self-glucosylation activity is lost but its intermolecular transglucosylation ability remains [7]. It continues to glucosylate an existing glucosyl group until a length of about 5--13 residues has been formed. Further lengthening of the glycogen chain is then carried out by EC 2.4.1.11, glycogen (starch) synthase. The enzyme is not highly specific for the donor, using UDP-xylose in addition to UDP-glucose (although not glucosylating or xylosylating a xylosyl group so added). It can also use CDP-glucose and TDP-glucose, but not ADP-glucose or GDP-glucose. Similarly it is not highly specific for the acceptor, using water (i.e. hydrolysing UDP-glucose) among others. Various forms of the enzyme exist, and different forms predominate in different organs. Thus primate liver contains glycogenin-2, of molecular mass 66 kDa, whereas the more widespread form is glycogenin-1, with a molecular mass of 38 kDa." +"2.4.1.187",Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls. +"2.4.1.189","The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye)." +"2.4.1.190","The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye)." +"2.4.1.191","The enzyme participates in the biosynthesis of luteolin triglucuronide, the major flavone found in the photosynthetically-active mesophyll of the primary leaves of Secale cereale (rye)." +"2.4.1.192",Some other sapogenins can act as glucosyl acceptors. Involved in the biosynthesis of plant saponins. Not identical with EC 2.4.1.173 (sterol 3beta-glucosyltransferase) or EC 2.4.1.193 (sarsapogenin 3beta-glucosyltransferase). +"2.4.1.193",Specific to 5beta-spirostanols. Involved in the biosynthesis of plant saponins. Not identical with EC 2.4.1.173 (sterol 3beta-glucosyltransferase) or EC 2.4.1.192 (nuatigenin 3beta-glucosyltransferase). +"2.4.1.195","The enzyme specifically glucosylates the thiohydroximate functional group. It is involved in the biosynthesis of glucosinolates in cruciferous plants, and acts on aliphatic, aromatic, and indolic substrates." +"2.4.1.197","The activity of the intersecting mannose residue as acceptor is dependent on two other mannose residues attached by alpha-1,3 and alpha-1,6 links." +"2.4.1.198","Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups." +"2.4.1.199",Involved in the formation of mannooligosaccharides in the membrane of Mycobacterium smegmatis. +"2.4.1.201","Requires a high concentration of Mn2+ for maximal activity. The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus. It transfers GlcNAc in beta1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by beta linkages. No homologous enzyme appears to exist in mammals." +"2.4.1.202","The enzyme is involved in the detoxification of the benzoxazinoids DIBOA (2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one) and DIMBOA (2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) which are stored as the respective non-toxic glucosides in the vacuoles in some plants, most commonly from the family of Poaceae (grasses). Benzoxazinoids are known to exhibit antimicrobial, antifeedant, and antiinsecticidal effects and are involved in the interaction of plants with other plants, insects, or microorganisms. +" +"2.4.1.203","Unlike EC 2.4.1.215, cis-zeatin O-beta-D-glucosyltransferase, UDP-D-xylose can also act as donor (cf. EC 2.4.2.40, zeatin O-beta-D-xylosyltransferase)." +"2.4.1.205",Galactogen from Helix pomatia is the most effective acceptor. +"2.4.1.207",Does not use cello-oligosaccharides as either donor or acceptor. +"2.4.1.208",The enzyme from Acholeplasma laidlawii requires Mg2+. +"2.4.1.209",cis-Caffeic acid also serves as a glucosyl acceptor with the enzyme from Sphagnum fallax kinggr. The corresponding trans-isomers are not substrates. +"2.4.1.210",The enzyme purified from navel orange albedo tissue also acts on the related tetranortriterpenoid nomilin. +"2.4.1.211","Reaction also occurs with beta-D-galactopyranosyl-(1->3)-N-acetyl-D-galactosamine as the substrate, giving N-acetyl-D-galactosamine as the product." +"2.4.1.212","The enzyme from Streptococcus Group A and Group C requires Mg2+. The enzyme adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, but it adds GlcA when the non-reducing end is GlcNAc [3]. The enzyme is highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or UDP-GalA. Similar enzymes have been found in a variety of organisms." +"2.4.1.213","Acts with EC 3.1.3.69 (glucosylglycerol phosphatase) to form glucosylglycerol, an osmolyte that endows cyanobacteria with resistance to salt." +"2.4.1.214","Requires Mn2+. The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. This enzyme catalyses a reaction similar to that of EC 2.4.1.68, glycoprotein 6-alpha-L-fucosyltransferase, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,3-linkage rather than an alpha1,6-linkage. The {iupac/misc/glycp#3.5::N-glycan} products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea)." +"2.4.1.215","The enzyme from maize can use cis-zeatin and UDP-glucose as substrates, but not cis-ribosylzeatin, trans-zeatin or trans-ribosylzeatin. Unlike EC 2.4.1.203, trans-zeatin O-beta-D-glucosyltransferase, UDP-D-xylose cannot act as a donor." +"2.4.1.216","The enzyme from Lactococcus lactis is specific for trehalose 6-phosphate. Differs from EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, in that trehalose is not a substrate." +"2.4.1.217","Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate." +"2.4.1.218","Hydroquinone is the most effective acceptor, but over 40 phenolic compounds are also glucosylated, but at lower rates. " +"2.4.1.219",The indole alkaloid raucaffricine accumulates during the culture of Rauvolfia cell suspensions. +"2.4.1.220","Also acts to a limited extent on 4-, 5-, 6- and 7-hydroxyindole. After enzymic or chemical hydrolysis, indican forms indoxyl, which, in turn, is converted in the presence of oxygen to the dye indigo." +"2.4.1.221","The enzyme, found in animals and plants, is involved in the biosynthesis of O-fucosylated proteins. In EGF domains, the attachment of O-linked fucose to serine or threonine occurs within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys. The POFUT3 and POFUT4 proteins modify EMI domains." +"2.4.1.222","The enzyme, found in animals and plants, is involved in the biosynthesis of the tetrasaccharides alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc and alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc, which are attached to L-Ser or L-Thr residues within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys in EGF-like domains in Notch and Factor-X proteins, respectively. The substrate is provided by EC 2.4.1.221, peptide-O-fucosyltransferase." +"2.4.1.223","Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core. Apparently products of both the human EXTL2 and EXTL3 genes can catalyse this reaction. In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase. For explanation of the use of a superscript in the systematic name, see {iupac/2carb/37#372::2-Carb-37.2}." +"2.4.1.224","Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the enzyme from human (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the 4-beta-glucuronosyltransferase (EC 2.4.1.225, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase) activity required for the synthesis of the heparan sulfate disaccharide repeats. Other human forms of this enzyme (e.g. the product of the EXTL1 gene) have only the 4-alpha-N-acetylglucosaminyltransferase activity. In Caenorhabditis elegans, the product of the rib-2 gene displays the activities of this enzyme as well as EC 2.4.1.223, glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase." +"2.4.1.225","Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC 2.4.1.224) activity required for the synthesis of the heparan sulfate disaccharide repeats." +"2.4.1.226","Involved in the biosynthesis of chondroitin and dermatan sulfate. The human chondroitin synthetase is a bifunctional glycosyltransferase, which has the 3-beta-glucuronosyltransferase and 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175) activities required for the synthesis of the chondroitin sulfate disaccharide repeats. Similar chondroitin synthase 'co-polymerases' can be found in Pasteurella multocida and Escherichia coli. There is also another human protein with apparently only the 3-beta-glucuronosyltransferase activity." +"2.4.1.227","The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, {iupac/misc/prenol#p6::click here})." +"2.4.1.228","For explanation of superscript II in systematic name, see {iupac/2carb/37#372::2-carb.37}." +"2.4.1.229","Skp1 is a cytoplasmic and nuclear protein required for the ubiquitination of cell cycle regulatory proteins and transcriptional factors. In Dictyostelium Skp1 is modified by the linear pentasaccharide Galalpha1-6Galalpha1-L-Fucalpha1-2Galbeta1-3GlcNAc, which is attached to a hydroxyproline residue at position 143. This enzyme catalyses the first step in the building up of the pentasaccharide by attaching an N-acetylglucosaminyl group to the hydroxyproline residue. It requires dithiothreitol and a divalent cation for activity." +"2.4.1.230","The enzyme from Thermoanaerobacter brockii can act with alpha-1,2-oligoglucans, such as selaginose, as substrate, but more slowly. The enzyme is inactive when dissaccharides with linkages other than alpha-1,2 linkages, such as sophorose, trehalose, neotrehalose, nigerose, laminaribiose, maltose, cellobiose, isomaltose, gentiobiose, sucrose and lactose, are used as substrates." +"2.4.1.231","Unlike EC 2.4.1.64, alpha,alpha-trehalose phosphorylase, this enzyme retains its anomeric configuration. Vanadate is a strong competitive inhibitor of this reversible reaction." +"2.4.1.232","Requires Mn2+. In Saccharomyces cerevisiae, this enzyme catalyses an essential step in the outer chain elongation of N-linked oligosaccharides. Man8GlcNAc and Man9GlcNAc are equally good substrates." +"2.4.1.234","Acts on the endogenous flavonols kaempferol and quercetin, to a lesser extent on myricetin and fisetin, and weakly on galangin and isorhamnetin. The reaction can occur equally well in both directions." +"2.4.1.235",Also acts on pelargonidin-3-rutinoside. The enzyme does not catalyse the glucosylation of the 5-hydroxy group of cyanidin-3-glucoside. +"2.4.1.236","Acts on the 7-O-glucoside of naringenin and hesperetin, also the flavone 7-O-glucosides of luteolin and apigenin." +"2.4.1.237","Acts on the flavonols gossypetin (8-hydroxyquercetin) and to a lesser extent on quercetin, kaempferol and myricetin. " +"2.4.1.238",Isolated from the plant Gentiana triflora (clustered gentian). +"2.4.1.239","One of three specific glucosyltransferases in pea (Pisum sativum) that successively add a beta-D-glucosyl group first to O-3 of kaempferol, and then to O-2 of the previously added glucosyl group giving the 3-O-sophoroside and then the 3-O-sophorotrioside (see also EC 2.4.1.91, flavonol 3-O-glucosyltransferase and EC 2.4.1.240, flavonol-3-O-glycoside glucosyltransferase). TDP-glucose can replace UDP-glucose as the glucose donor but the reaction proceeds more slowly." +"2.4.1.240","One of three specific glucosyltransferases in pea (Pisum sativum) thatsuccessively add a beta-D-glucosyl group first to O-3 of kaempferol, and then to O-2 of the previously added glucosyl group giving the 3-O-sophoroside and then the 3-O-sophorotrioside (see also EC 2.4.1.91 flavonol 3-O-glucosyltransferase, and EC 2.4.1.239 flavonol-3-O-glucoside glucosyltransferase)." +"2.4.1.241","Requires Mg2+. Diacylglycerol cannot serve as an acceptor molecule for galactosylation as in the reaction catalysed by EC 2.4.1.46, monogalactosyldiacylglyerol synthase. When phosphate is limiting, phospholipids in plant membranes are reduced but these are replaced, at least in part, by the glycolipids digalactosyldiacylglycerol (DGDG) and sulfoquinovosyldiacylglycerol [3]. While both DGD1 and DGD2 are increased under phosphate-limiting conditions, DGD2 does not contribute significantly under optimal growth conditions. DGD2 is responsible for the synthesis of DGDG molecular species that are rich in C16 fatty acids at sn-1 of diacylglycerol whereas DGD1 leads to molecular species rich in C18 fatty acids [3]. The enzyme has been localized to the outer side of chloroplast envelope membranes." +"2.4.1.242","Unlike EC 2.4.1.11, glycogen(starch) synthase and EC 2.4.1.21, starch synthase, which use UDP-glucose and ADP-glucose, respectively, this enzyme can use either UDP- or ADP-glucose. Mutants that lack the Wx (waxy) allele cannot produce this enzyme, which plays an important role in the normal synthesis of amylose. In such mutants, only amylopectin is produced in the endosperm [3] or pollen [5]." +"2.4.2.1","Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase." +"2.4.2.2","Unlike EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase, this enzyme can accept both the ribonucleosides uridine and cytidine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine [3,6]. The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction." +"2.4.2.3",The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. The mammalian enzyme also accepts 2'-deoxyuridine. +"2.4.2.4","The enzyme in some tissues also catalyses deoxyribosyltransferase reactions of the type catalysed by EC 2.4.2.6, nucleoside deoxyribosyltransferase." +"2.4.2.5",Base1 and base2 represent various purines and pyrimidines. +"2.4.2.6",Base1 and base2 represent various purines and pyrimidines. +"2.4.2.7","5-Amino-4-imidazolecarboxamide can replace adenine. " +"2.4.2.8",Guanine and purine-6-thiol can replace hypoxanthine. +"2.4.2.10","The enzyme from higher eukaryotes also catalyses the reaction listed as EC 4.1.1.23, orotidine-5'-phosphate decarboxylase." +"2.4.2.11","The enzyme, which is involved in pyridine nucleotide recycling, can form beta-nicotinate D-ribonucleotide and diphosphate from nicotinate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) in the absence of ATP. However, when ATP is available the enzyme hydrolyses it and utilizes the energy to drive the reaction from a products/substrates ratio of 0.67 to a value of 1100 [4]. In addition, the Km values for nicotinate and PRPP decrease by 200-fold when ATP is present." +"2.4.2.15",Also acts on deoxyguanosine. +"2.4.2.17",Involved in histidine biosynthesis. +"2.4.2.18","In some organisms, this enzyme is part of a multifunctional protein together with one or more other components of the system for biosynthesis of tryptophan [EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)]." +"2.4.2.19","The reaction is catalysed in the opposite direction. Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes [3]." +"2.4.2.20","Acts (in the reverse direction) on uracil and other pyrimidines and pteridines containing a 2,4-diketo structure. " +"2.4.2.21","Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin-biosynthesis pathway and is a substrate for EC 2.7.8.26, adenosylcobinamide-GDP ribazoletransferase [4]. It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73, alpha-ribazole phosphatase." +"2.4.2.25","7-O-beta-D-Glucosides of a number of flavonoids and of 4-substituted phenols can act as acceptors." +"2.4.2.26","Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). " +"2.4.2.28",Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy groups. +"2.4.2.29","Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eubacteria, which produce queuine de novo, the enzyme catalyses the exchange of guanine with the queuine precursor preQ1, which is ultimately modified to queuosine [5]. The enzyme can also use an earlier intermediate, preQ0, to replace guanine in unmodified tRNATyr and tRNAAsn [1]. This enzyme acts after EC 1.7.1.13, preQ1 synthase, in the queuine-biosynthesis pathway. cf. EC 2.4.2.64, tRNA-guanosine34 queuine transglycosylase." +"2.4.2.64","Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes and a small number of prokaryotes queuine is salvaged and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. cf. EC 2.4.2.29, tRNA-guanosine34 preQ1 transglycosylase." +"2.4.2.30","The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20--30 units." +"2.4.2.31","Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities [4]. Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly [1,5]. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymic activities. (cf. EC 2.4.2.36 NAD+---diphthamide ADP-ribosyltransferase)." +"2.4.2.34","The position of acylation is indeterminate because of the ease of acyl transfer between hydroxy groups. For a diagram showing the biosynthesis of UDP-L-arabinose, click here." +"2.4.2.35","Flavonol 3-O-glucoside, flavonol 3-O-galactoside and, more slowly, rutin, can act as acceptors." +"2.4.2.36","Diphtheria toxin and some other bacterial toxins catalyse this reaction, which inactivates translation elongation factor 2 (EF2). The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC 2.4.2.31 NAD(P)+---protein-arginine ADP-ribosyltransferase. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii." +"2.4.2.37","The combined action of this enzyme and EC 3.2.2.24, ADP-ribosyl-[dinitrogen reductase] hydrolase, controls the activity level of nitrogenase (EC 1.18.6.1). In the presence of ammonium, the product of nitrogenase, this enzyme covalently links an ADP-ribose moiety to a specific arginine residue of the dinitrogenase reductase component of nitrogenase, blocking its activity. " +"2.4.2.38",Specific for N-linked oligosaccharides (N-glycans). +"2.4.2.39","In association with EC 2.4.1.168 (xyloglucan 4-glucosyltransferase), this enzyme brings about the synthesis of xyloglucan; concurrent transfers of glucose and xylose are necessary for this synthesis." +"2.4.2.40",Does not act on UDP-glucose (cf. EC 2.4.1.103 alizarin 2-beta-glucosyltransferase). +"2.4.99.1",The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids. +"2.4.99.2","The enzyme recognizes the sequence beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl (known as type 1 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids [1]. When acting on gangloside GM1a, it forms gangloside GD1a [2]." +"2.4.99.3","alpha-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position." +"2.4.99.4","The acceptor is Galbeta1,3GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid. Lactose can also act as acceptor. May be identical with EC 2.4.99.2 monosialoganglioside sialyltransferase." +"2.4.99.5",The beta-D-galactosyl residue of the oligosaccharide of glycoproteins may also act as acceptor. +"2.4.99.6","The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1 [2]." +"2.4.99.7","Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure of alpha-N-acetyl-neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase." +"2.4.99.8",Gangliosides act as acceptors. +"2.4.99.9",Lactose cannot act as acceptor. +"2.5.1.1",This enzyme will not accept larger prenyl diphosphates as efficient donors. +"2.5.1.2",Various bases and thiol compounds can act instead of pyridine. +"2.5.1.3","The enzyme catalyses the penultimate reaction in thiamine de novo biosynthesis, condensing the pyrimidine and thiazole components. The enzyme is thought to accept the product of EC 2.8.1.10, thiazole synthase, as its substrate. However, it has been shown that in some bacteria, such as Bacillus subtilis, an additional enzyme, thiazole tautomerase (EC 5.3.99.10) converts that compound into its tautomer 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate, and that it is the latter that serves as the substrate for the synthase. In addition to this activity, the enzyme participates in a salvage pathway, acting on 4-methyl-5-(2-phosphooxyethyl)thiazole, which is produced from thiamine degradation products. In yeast this activity is found in a bifunctional enzyme (THI6) and in the plant Arabidopsis thaliana the activity is part of a trifunctional enzyme (TH1)." +"2.5.1.9",A flavoprotein (riboflavin). +"2.5.1.10",Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. The enzyme will not accept larger prenyl diphosphates as efficient donors. +"2.5.1.11","This enzyme will also use geranyl diphosphate and all-trans-prenyl diphosphates of intermediate size as donors, but not dimethylallyl diphosphate." +"2.5.1.15","The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [4], while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25, dihydroneopterin aldolase [3]. " +"2.5.1.16","The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor [2,7]. The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant towards other amine acceptors, such as spermidine and cadaverine [5,6]. cf. EC 2.5.1.22 (spermine synthase) and EC 2.5.1.23 (sym-norspermidine synthase)." +"2.5.1.17","The corrinoid adenosylation pathway comprises three steps: (i) reduction of Co(III) within the corrinoid to Co(II) by a one-electron transfer. This can occur non-enzymically in the presence of dihydroflavin nucleotides or reduced flavoproteins [3]. (ii) Co(II) is bound by corrinoid adenosyltransferase, resulting in displacement of the lower axial ligand by an aromatic residue. The reduction potential of the 4-coordinate Co(II) intermediate is raised by ~250 mV compared with the free compound, bringing it to within physiological range. This is followed by a second single-electron transfer from either free dihydroflavins or the reduced flavin cofactor of flavoproteins, resulting in reduction to Co(I) [7]. (iii) the Co(I) conducts a nucleophilic attack on the adenosyl moiety of ATP, resulting in transfer of the deoxyadenosyl group and oxidation of the cobalt atom to Co(III) state. Three types of corrinoid adenosyltransferases, not related by sequence, have been described. In the anaerobic bacterium Salmonella enterica they are encoded by the cobA gene (a housekeeping enzyme involved in both the de novo biosynthesis and the salvage of adenosylcobalamin), the pduO gene (involved in (S)-propane-1,2-diol utilization), and the eutT gene (involved in ethanolamine utilization). Since EutT hydrolyses triphosphate to diphosphate and phosphate during catalysis, it is classified as a separate enzyme. The mammalian enzyme belongs to the PduO type. The enzyme can act on other corrinoids, such as cob(II)inamide." +"2.5.1.18","A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange." +"2.5.1.20",Rubber particles act as acceptor. +"2.5.1.21","This microsomal enzyme catalyses the first committed step in the biosynthesis of sterols. The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP) [8]. High concentrations of FPP inhibit the production of squalene but not of PSPP [8]." +"2.5.1.22","The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase)." +"2.5.1.23","The enzyme has been originally characterized from the protist Euglena gracilis [1,2]. The enzyme from the archaeon Sulfolobus solfataricus can transfer the propylamine moiety from S-adenosyl 3-(methylsulfanyl)propylamine to putrescine, sym-norspermidine and spermidine with lower efficiency [3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.22 (spermine synthase)." +"2.5.1.25","3-[(3S)-3-amino-3-carboxypropyl]uridine (acp3U) is a highly conserved modification found in tRNA core region in bacteria and eukaryotes that confers thermal stability on tRNA. The enzyme from the bacterium Escherichia coli catalyses the modification of uridine47 in the V-loop of tRNAs for Arg2, Ile1, Ile2, Ile2v, Lys, Met, Phe, Val2A, and Val2B. The human homologs DTWD1 and DTWD2 are responsible for acp3U formation at positions 20 and 20a, respectively, in the D-loop of several cytoplasmic tRNAs." +"2.5.1.26",The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage. +"2.5.1.27","Involved in the biosynthesis of cytokinins in plants. Some isoforms from the plant Arabidopsis thaliana are specific for AMP while others also have the activity of EC 2.5.1.112, adenylate dimethylallyltransferase (ADP/ATP-dependent)." +"2.5.1.28",This enzyme will not use larger prenyl diphosphates as efficient donors. +"2.5.1.29",Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors. +"2.5.1.30","This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry." +"2.5.1.31","Undecaprenyl pyrophosphate synthase catalyses the consecutive condensation reactions of a farnesyl diphosphate with eight isopentenyl diphosphates, in which new cis-double bonds are formed, to generate undecaprenyl diphosphate that serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall [3]. " +"2.5.1.32","Requires Mn2+ for activity. The enzyme condenses two molecules of geranylgeranyl diphosphate to give prephytoene diphosphate, followed by rearrangement of the cyclopropylcarbinyl intermediate to 15-cis-phytoene." +"2.5.1.33","This enzyme will also use trans,trans-farnesyl diphosphate and all-trans-geranylgeranyl diphosphate as donors." +"2.5.1.35","This enzyme will also use as acceptor aspulvinone G, a hydroxylated derivative of the complex phenolic pigment aspulvinone E." +"2.5.1.36",Part of the glyceollin biosynthesis system in soy bean. +"2.5.1.38","The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the beta-lactam antibiotic nocardicin A. The enzyme can act on nocardicin E, F, and G, producing isonocardicin A, B, and C, respectively. However, the in vivo substrate is believed to be nocardicin G [3]." +"2.5.1.39","This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency [2,4,5]." +"2.5.1.41","This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria [2]. Requires Mg2+ for maximal activity [2]. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5]." +"2.5.1.42","This enzyme is an integral-membrane protein that carries out the second prenyltransfer reaction involved in the formation of polar membrane lipids in Archaea. Requires a divalent metal cation, such as Mg2+ or Mn2+, for activity [2]. 4-Hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate and alpha-glycerophosphate cannot act as prenyl-acceptor substrates [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase), which, together with this enzyme, alkylates the hydroxy groups of glycerol 1-phosphate to yield unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 [CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase] to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [3]. Belongs in the UbiA prenyltransferase family [2]." +"2.5.1.44","The reaction of this bacterial enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of either putrescine or spermidine, forming 4-iminobutan-1-amine or (E)-(4-aminobutylidene)(3-aminopropyl)amine, respectively, (b) attack by water forming 4-aminobutanal (and releasing ammonia or propane-1,3-diamine, respectively), and (c) condensation of 4-aminobutanal with putrescine, which forms homospermidine and restores NAD+. Differs from the eukaryotic enzyme EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group." +"2.5.1.45","A eukaryotic enzyme found in plants. The reaction occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of spermidine to 4-iminobutan-1-amine, (b) attack by water forming 4-aminobutanal (and releasing propane-1,3-diamine), and (c) condensation of 4-aminobutanal with purescine, which forms homospermidine and restores NAD+. This enzyme is more specific than EC 2.5.1.44, homospermidine synthase, which is found in bacteria, as it cannot use putrescine as donor of the 4-aminobutyl group. Forms part of the biosynthetic pathway of the poisonous pyrrolizidine alkaloids of the ragworts (Senecio)." +"2.5.1.46","The eukaryotic initiation factor eIF5A contains a hypusine residue that is essential for activity. This enzyme catalyses the first reaction of hypusine formation from one specific lysine residue of the eIF5A precursor. The reaction occurs in four steps: NAD+-dependent dehydrogenation of spermidine (1a), formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (Lys329 for the human enzyme; 1b), transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor (1c), reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue (1d). Hence the overall reaction is transfer of a 4-aminobutyl group. For the plant enzyme, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor. Hypusine is formed from deoxyhypusine by the action of EC 1.14.99.29, deoxyhypusine monooxygenase." +"2.5.1.47","A pyridoxal-phosphate protein. Some alkyl thiols, cyanide, pyrazole and some other heterocyclic compounds can act as acceptors. Not identical with EC 2.5.1.51 (beta-pyrazolylalanine synthase), EC 2.5.1.52 (L-mimosine synthase) and EC 2.5.1.53 (uracilylalanine synthase)." +"2.5.1.48","A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia." +"2.5.1.49","Also reacts with other thiols and H2S, producing homocysteine or thioethers. The name methionine synthase is more commonly applied to EC 2.1.1.13, methionine synthase. The enzyme from baker's yeast also catalyses the reaction of EC 2.5.1.47 cysteine synthase, but more slowly." +"2.5.1.50",The enzyme acts not only on zeatin but also on other N6-substituted adenines. The reaction destroys their cytokinin activity and forms the corresponding 3-(adenin-9-yl)-L-alanine. +"2.5.1.51",The enzyme is highly specific for acetylserine and pyrazole. Not identical with EC 2.5.1.52 L-mimosine synthase. +"2.5.1.52","Brings about the biosynthesis of L-mimosine in plants of the Mimosa and Leucaena genera. Not identical with EC 2.5.1.51, beta-pyrazolylalanine synthase." +"2.5.1.53","The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Acacia willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC 2.5.1.47 cysteine synthase." +"2.5.1.57",Acts on N-glycoloyl and N-acetyl-derivatives. +"2.5.1.58","This enzyme, along with protein geranylgeranyltransferase types I (EC 2.5.1.59) and II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction. A zinc metalloenzyme that requires Mg2+ for activity." +"2.5.1.59","This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type II (EC 2.5.1.60), constitutes the protein prenyltransferase family of enzymes. Catalyses the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC 2.5.1.58. The enzymes are relaxed in specificity for A1, but cannot act if A2 is aromatic. Known targets of this enzyme include most gamma-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. A zinc metalloenzyme. The Zn2+ is required for peptide, but not for isoprenoid, substrate binding." +"2.5.1.60","This enzyme, along with protein farnesyltransferase (EC 2.5.1.58) and protein geranylgeranyltransferase type I (EC 2.5.1.59), constitutes the protein prenyltransferase family of enzymes. Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion [5]." +"2.5.1.61","The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active centre. The terminal tetrapyrrole is then hydrolysed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues. In the presence of a second enzyme, EC 4.2.1.75 uroporphyrinogen-III synthase, which is often called cosynthase, the product is cyclized to form uroporphyrinogen-III. If EC 4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I." +"2.5.1.62","Requires Mg2+. The enzyme is modified by binding of the first substrate, phytyl diphosphate, before reaction of the modified enzyme with the second substrate, chlorophyllide a, can occur. The reaction also occurs when phytyl diphosphate is replaced by geranylgeranyl diphosphate." +"2.5.1.64","In the first step of the reaction, the oxoglutarate is decarboxylated and an adduct of the succinic semialdehyde is formed with thiamine diphosphate of the enzyme, as in both E1 of the 2-oxoglutarate dehydrogenase complex [EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring)] and in the reaction of 2-oxoglutarate decarboxylase (EC 4.1.1.71), which liberates free succinic semialdehyde." +"2.5.1.65","A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine." +"2.5.1.66",The enzyme requires thiamine diphosphate and catalyses the first step in the clavulanic-acid-biosynthesis pathway. The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group. +"2.6.1.1","A pyridoxal-phosphate protein. Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. Aspartate transaminase activity can be formed from the aromatic-amino-acid transaminase (EC 2.6.1.57) of Escherichia coli by controlled proteolysis [7], some EC 2.6.1.57 activity can be found in this enzyme from other sources [8]; indeed the enzymes are identical in Trichomonas vaginalis [6]." +"2.6.1.2",A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine. +"2.6.1.3",A pyridoxal-phosphate protein. +"2.6.1.4",A pyridoxal-phosphate protein. +"2.6.1.5",A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8]. +"2.6.1.6","A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form." +"2.6.1.7","A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction." +"2.6.1.8","A pyridoxal-phosphate protein. 2,5-Diaminoglutarate can act instead of diaminopentanoate." +"2.6.1.9",A pyridoxal-phosphate protein. +"2.6.1.11",A pyridoxal-phosphate protein. Also acts on L-ornithine and N2-succinyl-L-ornithine. +"2.6.1.12",A pyridoxal-phosphate protein. +"2.6.1.13",A pyridoxal-phosphate protein. +"2.6.1.14",A pyridoxal-phosphate protein. +"2.6.1.15",A pyridoxal-phosphate protein. L-Methionine can act as donor; glyoxylate can act as acceptor. +"2.6.1.16","Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination)." +"2.6.1.17",A pyridoxal-phosphate protein. +"2.6.1.18",A pyridoxal-phosphate protein. +"2.6.1.19","Requires pyridoxal phosphate. Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate. cf. EC 2.6.1.120, beta-alanine---2-oxoglutarate transaminase." +"2.6.1.21","A pyridoxal-phosphate protein. The enzyme from thermophilic Bacillus species acts on many D-amino acids with D-alanine and D-2-aminobutyrate as the best amino donors. It can similarly use any of several 2-oxo acids as amino acceptor, with 2-oxoglutarate and 2-oxobutyrate among the best. The enzyme from some other sources has a broader specificity [6]." +"2.6.1.22","Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, (R)-3-amino-2-methylpropionate---pyruvate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate." +"2.6.1.23","The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase." +"2.6.1.24","A pyridoxal-phosphate protein. Also acts on 3,5-dichloro-, 3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and triiodothyronine." +"2.6.1.26","A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors." +"2.6.1.27","A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids." +"2.6.1.28","Valine, leucine and isoleucine can replace tryptophan as amino donor." +"2.6.1.33",A pyridoxal-phosphate protein. +"2.6.1.34","A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N'-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [2-4] and O-linked glycosylation of certain L-serine residues in Neisseria species [5]." +"2.6.1.35",A pyridoxal-phosphate protein. +"2.6.1.36","A pyridoxal-phosphate protein. The product (L-allysine) is converted into the intramolecularly dehydrated form, (S)-2,3,4,5-tetrahydropyridine-2-carboxylate." +"2.6.1.37",A pyridoxal-phosphate protein. 2-Aminoethylarsonate can replace 2-aminoethylphosphonate as a substrate. +"2.6.1.39",A pyridoxal-phosphate protein. +"2.6.1.40","The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.22, (S)-3-amino-2-methylpropionate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate." +"2.6.1.41",Oxaloacetate can replace pyruvate. +"2.6.1.42","Also acts on L-isoleucine and L-valine, and thereby differs from EC 2.6.1.6, leucine transaminase, which does not. It also differs from EC 2.6.1.66, valine---pyruvate transaminase." +"2.6.1.43",A pyridoxal-phosphate protein. +"2.6.1.44","A pyridoxal-phosphate protein. With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. A second component also catalyses the reaction of EC 2.6.1.51 serine---pyruvate transaminase." +"2.6.1.45",A pyridoxal-phosphate protein. +"2.6.1.46",A pyridoxal-phosphate protein. +"2.6.1.47",A pyridoxal-phosphate protein. +"2.6.1.48",A pyridoxal-phosphate protein. +"2.6.1.49",A pyridoxal-phosphate protein. +"2.6.1.50",A pyridoxal-phosphate protein. +"2.6.1.51",A pyridoxal-phosphate protein. The liver enzyme may be identical with EC 2.6.1.44 alanine-glyoxylate transaminase. +"2.6.1.52","A pyridoxal 5'-phosphate protein. This enzyme catalyses the second step in the phosphorylated pathway of serine biosynthesis [1,3] and the third step in pyridoxal 5'-phosphate biosynthesis in the bacterium Escherichia coli [3]. Pyridoxal 5'-phosphate is the cofactor for both activities and therefore seems to be involved in its own biosynthesis [4]. Non-phosphorylated forms of serine and threonine are not substrates [4]. The archaeal enzyme has a relaxed specificity and can act on L-cysteate and L-alanine as alternative substrates to O-phospho-L-serine [7]." +"2.6.1.54","Also acts, more slowly, on pyridoxamine." +"2.6.1.55","A pyridoxal-phosphate protein. Also acts on D,L-3-amino-isobutanoate, beta-alanine and 3-aminopropanesulfonate. Involved in the microbial utilization of beta-alanine." +"2.6.1.56",L-Glutamate and L-glutamine can also act as amino donors. +"2.6.1.57","A pyridoxal-phosphate protein. L-Methionine can also act as donor, but more slowly; oxaloacetate can act as acceptor. Controlled proteolysis converts the enzyme into EC 2.6.1.1 aspartate transaminase." +"2.6.1.58","L-Histidine and L-tyrosine can act instead of L-phenylalanine; in the reverse reaction, L-methionine, L-serine and L-glutamine can replace L-alanine." +"2.6.1.59",A pyridoxal-phosphate protein. +"2.6.1.60","Phenylalanine, kynurenine, tyrosine and histidine can act as amino donors; glyoxylate, pyruvate and hydroxypyruvate can act as amino acceptors." +"2.6.1.62",A pyridoxal 5'-phosphate enzyme. S-adenosylhomocysteine can also act as donor. +"2.6.1.63","This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7, kynurenine---oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions." +"2.6.1.64","A pyridoxal-phosphate protein. L-Methionine, L-histidine and L-tyrosine can act as donors. The enzyme has little activity on pyruvate and glyoxylate (cf. EC 2.6.1.15 glutamine---pyruvate transaminase)." +"2.6.1.65",A pyridoxal-phosphate protein. +"2.6.1.66","Different from EC 2.6.1.42, branched-chain-amino-acid-transaminase." +"2.6.1.67","A pyridoxal-phosphate protein. Also acts on L-leucine and, more slowly, on L-isoleucine, L-2-aminopentanoate and L-aspartate." +"2.6.1.68","The enzyme from Trichomonas vaginalis also acts on L-lysine, producing 2,3,4,5-tetrahydropyridine-2-carboxylate." +"2.6.1.70","The enzyme from Pseudomonas putida also acts on 4-hydroxy-phenylpyruvate and, more slowly, on L-glutamate and L-histidine." +"2.6.1.72",A pyridoxal-phosphate protein. +"2.6.1.73",L-Glutamate can also act as donor. +"2.6.1.74","A number of D-amino acids, including D-alanine, D-aspartate and D-methionine can also act as amino-group donors. Although this enzyme acts on several free D-amino acids, it differs from EC 2.6.1.21, D-alanine transaminase, in that it can use cephalosporin C as an amino donor." +"2.6.1.75",A number of cysteine conjugates can also act. +"2.6.1.76","A pyridoxal-phosphate protein that requires potassium for activity [4]. In the proteobacterium Acinetobacter baumannii, this enzyme is cotranscribed with the neighbouring ddc gene that also encodes EC 4.1.1.86, diaminobutyrate decarboxylase. Differs from EC 2.6.1.46, diaminobutyrate---pyruvate transaminase, which has pyruvate as the amino-group acceptor. This is the first enzyme in the ectoine-biosynthesis pathway, the other enzymes involved being EC 2.3.1.178, diaminobutyrate acetyltransferase and EC 4.2.1.108, ectoine synthase [3,4]." +"2.6.1.77","The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group." +"2.6.1.78","A pyridoxal-phosphate protein. Glutamate can also act as the amino donor, but more slowly (cf. EC 2.6.1.79, glutamate---prephenate aminotransferase)." +"2.6.1.79","A pyridoxal-phosphate protein. Aspartate can also act as the amino donor, but more slowly (cf. EC 2.6.1.78, aspartate---prephenate aminotransferase). The enzyme from higher plants shows a marked preference for prephenate as substrate compared to pyruvate, phenylpyruvate or 4-hydroxyphenylpyruvate [1]." +"2.6.1.80","A pyridoxal-phosphate protein. This enzyme is produced by grasses. They secrete both the nicotianamine and the transaminated product into the soil around them. Both compounds chelate iron(II) and iron(III); these chelators, called mugineic acid family phytosiderophores, are taken up by the grass, which is thereby supplied with iron." +"2.6.3.1",Acetaldehyde can act instead of acetone; D-glucose oxime can act instead of pyruvate oxime. +"2.6.99.1","The purine residue is transferred on to the apurinic site forming a normal glycosylic bond. dATP reacts at sites of the double-stranded depurinated DNA that lack adenine, and dGTP at sites that lack guanine." +"2.7.1.1","D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase." +"2.7.1.2",A group of enzymes found in invertebrates and microorganisms that are highly specific for glucose. +"2.7.1.3","D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [4]." +"2.7.1.6",Part of the Leloir pathway for galactose metabolism. The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-alpha-D-galactosamine [4-6]. +"2.7.1.8","The enzyme is specific for glucosamine and has only a minor activity with D-glucose. Two unrelated enzymes with this activity have been described. One type was studied in the bacterium Vibrio cholerae, where it participates in a chitin degradation pathway. The other type has been described from actinobacteria, where it is involved in the incorporation of environmental glucosamine into antibiotic biosynthesis pathways. cf. EC 2.7.1.147, ADP-specific glucose/glucosamine kinase." +"2.7.1.11","The enzyme from rabbit muscle displays absolute stereoselectivity for the beta-anomer of D-fructofuranose 6-phosphate [9-11]. D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as acceptors. UTP, CTP and ITP can act as donors. Not identical with EC 2.7.1.105 6-phosphofructo-2-kinase." +"2.7.1.15","2-Deoxy-D-ribose can also act as acceptor." +"2.7.1.16",Ribitol and L-arabinitol can also act as acceptors. +"2.7.1.20","2-Aminoadenosine can also act as acceptor. " +"2.7.1.21","Deoxyuridine can also act as acceptor, and dGTP can act as a donor. The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.114 (AMP---thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP-kinase)." +"2.7.1.25","The human phosphoadenosine-phosphosulfate synthase (PAPSS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25)." +"2.7.1.26","The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates [5]. While monofunctional riboflavin kinase is found in eukaryotes, some bacteria have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.7.2, FMN adenylyltransferase [5]. A divalent metal cation is required for activity (with different species preferring Mg2+, Mn2+ or Zn2+). In Bacillus subtilis, ATP can be replaced by other phosphate donors but with decreasing enzyme activity in the order ATP > dATP > CTP > UTP [6]. " +"2.7.1.27","The enzyme has been characterized from the bacterium Propionibacterium acidipropionici (previously known as Propionibacterium pentosaceum). cf. EC 2.7.1.215, erythritol kinase (L-erythritol 4-phosphate-forming)." +"2.7.1.30","Glycerone and L-glyceraldehyde can act as acceptors; UTP (and, in the case of the yeast enzyme, ITP and GTP) can act as donors." +"2.7.1.32",Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. +"2.7.1.35","Pyridoxine, pyridoxamine and various derivatives can also act as acceptors. " +"2.7.1.36","CTP, GTP and UTP can also act as donors. " +"2.7.1.37","A group of enzymes that are under review by the NC-IUBMB. Other present entries are EC 2.7.1.38 (phosphorylase kinase), EC 2.7.1.99 {[pyruvate dehydrogenase (acetyl-transferring)] kinase}, EC 2.7.1.109 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase), EC 2.7.1.110 (dephospho-[reductase kinase] kinase); EC 2.7.1.112 (protein-tyrosine kinase), EC 2.7.1.115 ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] kinase), EC 2.7.1.116 {[isocitrate dehydrogenase (NADP+)] kinase}, EC 2.7.1.123 (Ca2+/calmodulin-dependent protein kinase), EC 2.7.1.124 ([tyrosine 3-monooxygenase] kinase), EC 2.7.1.125 (rhodopsin kinase), EC 2.7.1.126 ([beta-adrenergic receptor] kinase), EC 2.7.1.135 (tau-protein kinase) and EC 2.7.1.141 ([RNA-polymerase]-subunit kinase). Some enzymes are activated by cyclic GMP, but not by cyclic AMP, and some enzymes are not activated by either." +"2.7.1.38",See comment on EC 2.7.1.37 protein kinase. +"2.7.1.40","UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2." +"2.7.1.45","The enzyme shows no activity with 2-dehydro-3-deoxy-D-galactonate [1]. cf. EC 2.7.1.178, 2-dehydro-3-deoxyglucono/2-dehydro-3-deoxygalactonokinase." +"2.7.1.48","The enzyme, found in prokaryotes and eukaryotes, phosphorylates both uridine and cytidine to their monophosphate forms. The enzyme from Escherichia coli prefers GTP to ATP. The human enzyme also catalyses the phosphorylation of several cytotoxic ribonucleoside analogs. cf. EC 2.7.1.213, cytidine kinase." +"2.7.1.49","CTP, UTP and GTP can act as donors. " +"2.7.1.52","Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly." +"2.7.1.56","ITP, GTP or UTP can replace ATP. " +"2.7.1.59",The bacterial enzyme also acts on D-glucose. +"2.7.1.60",Acts on the acetyl and glycolyl derivatives. +"2.7.1.61","Phosphorylates D-glucose and D-mannose on O-6, and D-fructose on O-1 or O-6." +"2.7.1.62",Activity is observed with several hexoses; of these glucose is the best substrate and the product from it is alpha-D-glucose 1-phosphate. The phosphoramidate donor can be replaced by N-phosphoglycine and by an N-phosphohistidine. May be identical with EC 3.1.3.9 glucose-6-phosphatase. +"2.7.1.63","Requires a neutral salt, e.g. KCl, for maximum activity. Also acts on glucosamine." +"2.7.1.65","Also acts on streptamine, 2-deoxystreptamine and 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol." +"2.7.1.67",This reaction is catalysed by at least two different isoforms. +"2.7.1.68","This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known." +"2.7.1.69","Enzyme II of the phosphotransferase system. Comprises a group of related enzymes. The protein substrate is a phosphocarrier protein of low molecular mass (9.5 kDa). The protein is phosphorylated in a reaction catalysed by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase) and this acts as the phosphate donor for the above reaction. The enzyme translocates the sugar it phosphorylates into bacteria. Aldohexoses, and their glycosides and alditols, are phosphorylated on O-6, whereas fructose and sorbose are phosphorylated on O-1. Glycerone and disaccharides are also substrates." +"2.7.1.72","dATP can replace ATP; and dihydrostreptomycin, streptidine and 2-deoxystreptidine can act as acceptors." +"2.7.1.74",Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors. +"2.7.1.76","2'-Deoxyguanosine can also act as acceptor. Possibly identical with EC 2.7.1.74 deoxycytidine kinase." +"2.7.1.77","Phenyl phosphate and nucleoside 3'-phosphates can act as donors, although not so well as nucleoside 5'-phosphates. Nucleosides as well as 2'-deoxyribonucleosides can act as acceptors. " +"2.7.1.78",Also acts on 5'-dephospho-RNA 3'-mononucleotides. +"2.7.1.79",May be identical with EC 3.1.3.9 glucose-6-phosphatase. +"2.7.1.81",Both the natural 5-hydroxy-L-lysine and its 5-epimer act as acceptors. +"2.7.1.85","Phosphorylates a number of beta-D-glucosides; GTP, CTP, ITP and UTP can also act as donors." +"2.7.1.86","CTP, ITP, UTP and GTP can also act as phosphate donors (in decreasing order of activity). The enzyme is specific for NADH. Activated by acetate." +"2.7.1.87","Also phosphorylates dihydrostreptomycin, 3'-deoxydihydrostreptomycin and their 6-phosphates." +"2.7.1.88","3'-Deoxydihydrostreptomycin 6-phosphate can also act as acceptor." +"2.7.1.90","The enzyme catalyses a similar reaction to EC 2.7.1.11, 6-phosphofructokinase, but utilizes diphosphate instead of ATP as the the phosphate donor. It has been described in higher plants, primitive eukaryotes, bacteria, and archaea." +"2.7.1.91","The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species." +"2.7.1.94",Acts on both 1- and 2-acylglycerols. +"2.7.1.95","Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin." +"2.7.1.99",A mitochondrial enzyme associated with the pyruvate dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring). See comment on EC 2.7.1.37 protein kinase. +"2.7.1.100","CTP also acts, but more slowly." +"2.7.1.101",The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways. +"2.7.1.102","Also acts, more slowly, on D-hamamelitol." +"2.7.1.103",Acts also on capreomycins. A serine residue in the peptide antibiotics acts as phosphate-acceptor. +"2.7.1.105","Not identical with EC 2.7.1.11 6-phosphofructokinase. The enzyme co-purifies with EC 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase." +"2.7.1.106","D-Glucose 6-phosphate can act as acceptor, forming alpha-D-glucose 1,6-bisphosphate." +"2.7.1.107","Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Activity is stimulated by certain phospholipids [4,7]. In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. cf. EC 2.7.1.174, diacylglycerol kinase (CTP)." +"2.7.1.109",EC 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. See comment on EC 2.7.1.37 protein kinase. +"2.7.1.110",Phosphorylates and activates EC 2.7.1.109 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase that has been inactivated by EC 3.1.3.16 phosphoprotein phosphatase. See comment on EC 2.7.1.37 protein kinase. +"2.7.1.112","There are many eukaryotic genes for this type of enzyme, some of which are closely related. Nucleotides other than ATP may also act as donors. See comment on EC 2.7.1.37 protein kinase." +"2.7.1.113",Deoxyinosine can also act as acceptor. +"2.7.1.114","The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.118 (ADP---thymidine kinase) and EC 2.7.4.9 (dTMP kinase)." +"2.7.1.115",A mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring). See comment on EC 2.7.1.37 protein kinase. +"2.7.1.116",Phosphorylates and inactivates EC 1.1.1.42 isocitrate dehydrogenase (NADP+). See comment on EC 2.7.1.37 protein kinase. +"2.7.1.117","Requires Ca2+ and calmodulin. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly." +"2.7.1.118","The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyses this reaction as well as those of EC 2.7.1.21 (thymidine kinase), EC 2.7.1.114 (AMP---thymidine kinase) and EC 2.7.4.9 (dTMP kinase)." +"2.7.1.119","Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7''-hydroxy group in the destomic acid ring." +"2.7.1.120",Requires Ca2+ and calmodulin. Phosphorylation abolishes the ability of the protein caldesmon to bind actin and inhibit ATPase. The enzyme appears to be identical with caldesmon; the reaction is an autophosphorylation. +"2.7.1.123","Requires calmodulin and Ca2+. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase), EC 2.7.11.17 (Ca2+/calmodulin-dependent protein kinase) or EC 2.7.11.26 (tau-protein kinase)." +"2.7.1.124","Activates EC 1.14.16.2 tyrosine 3-monooxygenase, by phosphorylation. Specific for this substrate, with which it co-purifies. See comment on EC 2.7.1.37 protein kinase." +"2.7.1.125","Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.1.126 [beta-adrenergic-receptor] kinase)." +"2.7.1.126","Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. Inhibited by Zn2+ and digitonin; unaffected by cyclic-AMP (cf. EC 2.7.1.125 rhodopsin kinase). See comment on EC 2.7.1.37 protein kinase." +"2.7.1.127",Activated by Ca2+. Three isoforms have been shown to exist [3]. +"2.7.1.128",Phosphorylates and inactivates EC 6.4.1.2 acetyl-CoA carboxylase. See comment on EC 2.7.1.37 protein kinase. +"2.7.1.129","The enzyme from Dictyostelium sp. brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. One threonine residue in each heavy chain acts as acceptor." +"2.7.1.130","Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria." +"2.7.1.131",Phosphorylates the serine-833 in the cytoplasmic domain of the low-density lipoprotein receptor. GTP can act instead of ATP. +"2.7.1.132",Also phosphorylates casein. The acceptor is a serine residue in the protein. +"2.7.1.134","This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP. The enzymes from animals and plants also have the activity of EC 2.7.1.159, inositol-1,3,4-trisphosphate 5/6-kinase." +"2.7.1.135","Activated by tubulin. Different from EC 2.7.1.123 Ca2+/calmodulin-dependent protein kinase: not activated by calmodulin, cyclic nucleotides or Ca2+. Involved in the formation of paired helical filaments in brain. See comment on EC 2.7.1.37 protein kinase." +"2.7.1.136","Erythromycin, spiramycin and some other macrolide antibiotics can also act as acceptors." +"2.7.1.137",One mammalian isoform is known. +"2.7.1.140","The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P5 as a substrate [2]." +"2.7.1.141",The enzyme appears to be distinct from other protein phosphokinases. It brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6 DNA-directed RNA polymerase. +"2.7.1.142",Involved in the anaerobic metabolism of sugars in the bloodstream of trypanosomes. +"2.7.1.143","The enzyme from the Acholeplasma class of Mollicutes catalyses the conversion of adenosine, guanosine and inosine to AMP, GMP and IMP. ATP cannot substitute for diphosphate as a substrate." +"2.7.1.145",The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides. +"2.7.1.146","ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective." +"2.7.1.147","Requires Mg2+. The enzyme, characterized from a number of hyperthermophilic archaeal species, is highly specific for ADP. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate. " +"2.7.1.148","The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here)." +"2.7.1.151","This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase [4]." +"2.7.1.153","This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist." +"2.7.1.154",This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date. +"2.7.1.156","In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC 2.7.8.26, adenosylcobinamide-GDP ribazoletransferase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62, adenosylcobinamide-phosphate guanylyltransferase) activities. However, both activities are not required at all times. The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin [4]." +"2.7.1.157","The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity." +"2.7.2.1","Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate [4], others have found that the enzyme can also use propanoate as a substrate, but more slowly [7]. Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate [9]." +"2.7.2.2","The enzyme catalyses the reversible conversion of carbamoyl phosphate and ADP to ATP and carbamate, which hydrolyses to ammonia and hydrogencarbonate. The physiological role of the enzyme is to generate ATP. " +"2.7.2.4","The enzyme from Escherichia coli is a multifunctional protein, which also catalyses the reaction of EC 1.1.1.3 homoserine dehydrogenase. This is also the case for two of the four isoenzymes in Arabidopsis thaliana. The equilibrium constant strongly favours the reaction from right to left, i.e. the non-physiological direction of reaction." +"2.7.2.7","The enzyme from Clostridium sp. also acts, more slowly, on pentanoate and propanoate, and on some branched-chain fatty acids (cf. EC 2.7.1.14 sedoheptulokinase)." +"2.7.2.11","In the absence of downstream enzymes, the product rapidly cyclizes to 5-oxo-L-proline and phosphate." +"2.7.2.14","3-Methylbutanoate, 2-methylbutanoate, pentanoate, butanoate and propanoate can also act as acceptors (cf. EC 2.7.2.7 butyrate kinase)." +"2.7.2.15","Requires Mg2+. Acetate can also act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [1]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate [1]." +"2.7.3.2",N-Ethylglycocyamine can also act as acceptor. +"2.7.3.5",Also acts on methylated lombricines such as thalassemine; the specificity varies with the source species. +"2.7.3.6","Also acts, more slowly, on taurocyamine." +"2.7.3.7","Has a little activity on taurocyamine, lombricine and phosphotaurocyamine." +"2.7.3.8","Has a wide specificity. In the reverse direction, N-phosphoglycine and N-phosphohistidine can also act as phosphate donors, and ADP, dADP, GDP, CDP, dTDP, dCDP, IDP and UDP can act as phosphate acceptors (in decreasing order of activity)." +"2.7.3.9","Enzyme I of the phosphotransferase system (cf. EC 2.7.1.191, EC 2.7.1.192, EC 2.7.1.193, EC 2.7.1.194, EC 2.7.1.195, EC 2.7.1.196, EC 2.7.1.197, EC 2.7.1.198, EC 2.7.1.199, EC 2.7.1.200, EC 2.7.1.201, EC 2.7.1.202, EC 2.7.1.203, EC 2.7.1.204, EC 2.7.1.205, EC 2.7.1.206, EC 2.7.1.207 and EC 2.7.1.208). Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. A similar reaction, where the protein is the enzyme EC 2.7.9.2 pyruvate, water dikinase, is part of the mechanism of that enzyme." +"2.7.3.10","L-Arginine can act as acceptor, but more slowly." +"2.7.3.11",A number of histones can act as acceptor. +"2.7.3.12",A number of histones can act as acceptor. +"2.7.4.1","The enzyme is responsible for the synthesis of most of the cellular polyphosphate, using the terminal phosphate of ATP as substrate." +"2.7.4.3",Inorganic triphosphate can also act as donor. +"2.7.4.4",Many nucleotides can act as acceptors; other nucleoside triphosphates can act instead of ATP. +"2.7.4.6","Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors." +"2.7.4.8","dGMP can also act as acceptor, and dATP can act as donor." +"2.7.4.10",Many nucleoside triphosphates can act as donors. +"2.7.4.11",AMP can also act as acceptor. +"2.7.4.12",dTMP and dAMP can act as acceptors; dATP can act as donor. +"2.7.4.13",dATP can substitute for ATP. +"2.7.4.14","This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, (d)CMP kinase and EC 2.7.4.22, UMP kinase." +"2.7.4.18",ADP can also act as donor. +"2.7.4.19","The enzyme, from phage XP-12-infected Xanthomonas oryzae, converts m5dCMP into m5dCDP and then into m5dCTP." +"2.7.4.21",Three mammalian isoforms are known to exist. +"2.7.6.1",dATP can also act as donor. +"2.7.6.3","Binds 2 Mg2+ ions that are essential for activity [4]. The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants, fungi, and some archaeal species, including the haloarchaea) and methanopterin (in some archaeal species such as the Archaeoglobi and Methanobacteria). The enzyme exists in varying types of multifunctional proteins in different organisms. The enzyme from the bacterium Streptococcus pneumoniae also harbours the activity of EC 4.1.2.25, dihydroneopterin aldolase [4], the enzyme from the plant Arabidopsis thaliana harbours the activity of EC 2.5.1.15, dihydropteroate synthase [7], while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities [6]. " +"2.7.6.4","The enzyme acts on the 5'-mono-, di- and triphosphate derivatives of purine nucleosides." +"2.7.6.5",GDP can also act as acceptor. +"2.7.7.1",Nicotinate nucleotide can also act as acceptor. See also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase. +"2.7.7.2","Requires Mg2+ and is highly specific for ATP as phosphate donor [5]. The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates [3]. While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26, riboflavin kinase [3,5]." +"2.7.7.3","The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase." +"2.7.7.4","The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme (fusion product of two catalytic activities). In a first step, sulfate adenylyltransferase catalyses the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate. The second step is catalysed by the adenylylsulfate kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme-bound APS and ATP. In contrast, in bacteria, yeast, fungi and plants, the formation of PAPS is carried out by two individual polypeptides, sulfate adenylyltransferase (EC 2.7.7.4) and adenylyl-sulfate kinase (EC 2.7.1.25)." +"2.7.7.6","Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase)." +"2.7.7.7","Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. See also EC 2.7.7.49 RNA-directed DNA polymerase." +"2.7.7.8","ADP, IDP, GDP, UDP and CDP can act as donors." +"2.7.7.10","alpha-D-Glucose 1-phosphate can also act as acceptor, but more slowly." +"2.7.7.13",The bacterial enzyme can also use ITP and dGTP as donors. +"2.7.7.19","Also acts slowly with CTP. Catalyses template-independent extension of the 3'- end of an RNA strand by one nucleotide at a time. Cannot initiate a chain de novo. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. See also EC 2.7.7.6 DNA-directed RNA polymerase." +"2.7.7.21",May be identical with EC 2.7.7.25 tRNA adenylyltransferase. +"2.7.7.23","Part of the pathway for acetamido sugar biosynthesis in bacteria and archaea. The enzyme from several bacteria (e.g., Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase [3,4,6]. The enzyme from plants and animals is also active toward N-acetyl-alpha-D-galactosamine 1-phosphate (cf. EC 2.7.7.83, UDP-N-acetylgalactosamine diphosphorylase) [5,7], while the bacterial enzyme shows low activity toward that substrate [4]." +"2.7.7.24",Involved in the biosynthesis of L-rhamnose in bacteria. +"2.7.7.25",May be identical with EC 2.7.7.21 tRNA cytidylyltransferase. +"2.7.7.72","The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition [5]." +"2.7.7.28","In decreasing order of activity, guanosine, inosine and adenosine diphosphate hexoses are substrates in the reverse reaction, with either glucose or mannose as the sugar." +"2.7.7.31",Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or 2'-deoxyribo-. +"2.7.7.34","Also acts, more slowly, on D-mannose 1-phosphate." +"2.7.7.35","The enzyme, characterized from the single-celled alga Euglena gracilis, catalyses an irreversible reaction in the direction of ADP formation. cf. EC 2.7.7.96, ADP-D-ribose pyrophosphorylase." +"2.7.7.37","The enzyme works on a variety of alpha-D-aldose 1-phosphates and beta-L-aldose 1-phosphates (which have the same anomeric configuration as the former; see 2-Carb-6.2)." +"2.7.7.39",Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls. +"2.7.7.42","This bacterial enzyme adenylates a tyrosine residue of EC 6.3.1.2, glutamine synthetase. The enzyme is bifunctional, and also catalyses a reaction that removes the adenyl group from the modified tyrosine residue (cf. EC 2.7.7.89, [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase) [7,8]. The two activities are present on separate domains." +"2.7.7.43",Acts on N-acetyl- and N-glycolyl- derivatives. +"2.7.7.44",Also acts slowly with CTP. +"2.7.7.45","Also acts, more slowly, on GDP to form P1,P3-bis(5'-guanosyl) triphosphate." +"2.7.7.46","ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic." +"2.7.7.47",Also acts on spectinomycin. +"2.7.7.48",Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase. +"2.7.7.49",Catalyses RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase. +"2.7.7.50","The human enzyme is a multi domain protein that also has the activity of EC 3.6.1.74, mRNA 5'-phosphatase." +"2.7.7.52",The enzyme requires an oligoribonucleotide or polyribonucleotide with a free terminal 3'-OH as a primer. +"2.7.7.53",GTP and adenosine tetraphosphate can also act as adenylyl acceptors. +"2.7.7.54",Part of the system for biosynthesis of the alkaloid cyclopeptine in Penicillium cyclopium. +"2.7.7.55",Part of the system for biosynthesis of the alkaloid cyclopeptine in Penicillium cyclopium. +"2.7.7.56","Brings about the final exonucleolytic trimming of the 3'-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3'-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase." +"2.7.7.59","The enzyme uridylylates and de-uridylylates the small trimeric protein PII. The enzymes from Escherichia coli and Salmonella typhimurium have been wrongly identified, in some databases, as EC 2.7.7.12 (UDP-glucose---hexose-1-phosphate uridylyltransferase), from which it differs greatly in both reaction catalysed and sequence." +"2.7.7.60","The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here)." +"2.7.7.61","The gamma-subunit of EC 4.1.3.6, citrate (pro-3S) lyase, serves as an acyl-carrier protein (ACP) and contains the cofactor 2'-(5-triphosphoribosyl)-3'-dephospho-CoA [1,3]. Synthesis and attachment of the cofactor requires the concerted action of this enzyme and EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase [1]. In the enzyme from Escherichia coli, the cofactor is attached to serine-14 of the ACP via a phosphodiester bond." +"2.7.7.62","In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nuclotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC 2.7.8.26, cobalamin synthase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62) activities. However, both activities are not required at all times.The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin [4]. The guanylyltransferase reaction is a two-stage reaction with formation of a CobU-GMP intermediate [1]. Guanylylation takes place at histidine-46." +"2.7.8.2","1-Alkyl-2-acylglycerol can act as acceptor; this activity was previously listed separately." +"2.7.8.5",The enzyme catalyses the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins. +"2.7.8.7","Requires Mg2+. All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post-translational modification of their constituent acyl-carrier-protein (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4'-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain [3]. The enzyme from human can activate both the ACP domain of the human cytosolic multifunctional fatty-acid synthase system (EC 2.3.1.85) and that associated with human mitochondria as well as peptidyl-carrier and acyl-carrier-proteins from prokaryotes [6]. Removal of the 4-phosphopantetheinyl moiety from holo-ACP is carried out by EC 3.1.4.14, [acyl-carrier-protein] phosphodiesterase." +"2.7.8.12","Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme adds 30--50 glycerol units to the linker molecule, but only after it has been primed with the first glycerol unit by EC 2.7.8.44, teichoic acid poly(glycerol phosphate) primase. cf. EC 2.7.8.45, teichoic acid glycerol-phosphate transferase." +"2.7.8.13","In Gram-negative and some Gram-positive organisms the L-lysine is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm), which is combined with adjacent residues through its L-centre. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here)." +"2.7.8.14",Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds around 40 ribitol units to the linker molecule. +"2.7.8.17","Some other glycoproteins with high-mannose can act as acceptors, but much more slowly than lysosomal enzymes." +"2.7.8.18",N-Acetylglucosamine end-groups in glycoproteins can also act as acceptors. +"2.7.8.19",Penultimate mannose residues on oligo-mannose type glycoproteins can act as acceptors. +"2.7.8.20","1,2-beta- and 1,6-beta-linked glucose residues in membrane polysaccharides and in synthetic glucosides can act as acceptors." +"2.7.8.21","beta-Linked glucose residues in simple glucosides, such as gentiobiose, can act as acceptors. In the presence of low concentrations of acceptor, free cyclic 1,2-phosphoglycerol is formed." +"2.7.8.23","Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos." +"2.7.8.24","Requires divalent cations, with Mn2+ being more effective than Mg2+." +"2.7.8.25","ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (gamma-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase [4]." +"2.7.8.26","In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. CobS catalyses the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with alpha-ribazole to yield adenosylcobalamin." +"2.7.9.2",A manganese protein. +"2.7.9.3",Mg2+-dependent enzyme identified in Escherichia coli +"2.7.9.4","Requires Mg2+. ATP appears to be the only phosphate donor. No activity could be detected using GTP, UTP, phosphoenolpyruvate or diphosphate [1]. The protein phosphorylates glucans exclusively on O-6 of glucosyl residues [2]. The protein phosphorylates itself with the beta-phosphate of ATP, which is then transferred to the glucan [1]." +"2.7.9.5","The enzyme phosphorylates granular starch that has previously been phosphorylated by EC 2.7.9.4, alpha-glucan, water dikinase; there is no activity with unphosphorylated glucans. It transfers the beta-phosphate of ATP to the phosphoglucan, whereas the gamma-phosphate is transferred to water [1]. In contrast to EC 2.7.9.4, which phosphorylates glucose groups in glucans on O-6, this enzyme phosphorylates glucose groups in phosphorylated starch on O-3 [2]. The protein phosphorylates itself with the beta-phosphate of ATP, which is then transferred to the glucan [1]." +"2.8.1.1",A few other sulfur compounds can act as donors. +"2.8.1.2","The enzyme catalyses a transsulfuration reaction from 2-oxo-3-sulfanylpropanoate to an internal cysteine residue. In the presence of a dithiol such as reduced thioredoxin or dihydrolipoate, the sulfanyl sulfur is released as hydrogen sulfide. The enzyme participates in a sulfur relay process that leads to the 2-thiolation of some tRNAs and to protein urmylation by transferring sulfur between the NFS1 cysteine desulfurase (EC 2.8.1.7) and the MOCS3 sulfurtransferase (EC 2.8.1.11)." +"2.8.1.3","The primary product is glutathione hydrodisulfide, which reacts with glutathione to give glutathione disulfide and sulfide. L-Cysteine can also act as acceptor." +"2.8.1.4","The enzyme, found in bacteria and archaea, is activated by EC 2.8.1.7, cysteine desulfurase, which transfers a sulfur atom to an internal L-cysteine residue, forming a cysteine persulfide. The activated enzyme then transfers the sulfur to a uridine in a tRNA chain in a reaction that requires ATP. The enzyme from the bacterium Escherichia coli forms 4-thiouridine only at position 8 of tRNA. The enzyme also participates in the biosynthesis of the thiazole moiety of thiamine, but different domains are involved in the two processes." +"2.8.1.5","The enzyme from Chlorella shows very little activity towards monothiols such as glutathione and cysteine (cf. EC 2.8.1.3 thiosulfate---thiolsulfurtransferase). The enzyme probably transfers the sulfur atom onto one thiol group to form -S-S-, and sulfide is spontaneously expelled from this by reaction with the other thiol group. May be identical with EC 2.8.1.1 thiosulfate sulfurtransferase." +"2.8.1.6","The enzyme binds a [4Fe-4S] and a [2Fe-2S] cluster. In every reaction cycle, the enzyme consumes two molecules of AdoMet. The first reaction produces 5'-deoxyadenosine and 4,5-secobiotin. Reaction with another equivalent of AdoMet results in abstraction of the C-6 methylene pro-S hydrogen atom from 4,5-secobiotin, and the resulting carbon radical is quenched via formation of an intramolecular C-S bond, thus closing the biotin tetrahydrothiophene ring. The sulfur donor is believed to be the [2Fe-2S] cluster, which is sacrificed in the process, so that in vitro the reaction is a single turnover. In vivo, the [2Fe-2S] cluster can be reassembled by the Isc or Suf iron-sulfur cluster assembly systems, to allow further catalysis." +"3.1.1.85","Involved in biotin biosynthesis in Gram-negative bacteria. The enzyme exhibits carboxylesterase activity, particularly toward substrates with short acyl chains [1,2]. Even though the enzyme can interact with coenzyme A thioesters [3], the in vivo role of the enzyme is to hydrolyse the methyl ester of pimeloyl-[acyl carrier protein], terminating the part of the biotin biosynthesis pathway that is catalysed by the fatty acid elongation enzymes [4]." +"2.8.1.7","A pyridoxal-phosphate protein. The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors. The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) [2]. In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation [1]." +"2.8.2.1",A number of aromatic compounds can act as acceptors. Organic hydroxylamines are not substrates (cf. EC 2.8.2.9 tyrosine-ester sulfotransferase). +"2.8.2.2","Primary and secondary alcohols, including aliphatic alcohols, ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15 steroid sulfotransferase)." +"2.8.2.3","A large number of primary and secondary amines can act as acceptors, including aniline, 2-naphthylamine, cyclohexylamine and octylamine." +"2.8.2.5",The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase. +"2.8.2.8","The enzyme also catalyses the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent." +"2.8.2.9",Phenols and organic hydroxylamines can act as acceptors (cf. EC 2.8.2.1 aryl sulfotransferase). +"2.8.2.10",The product may be identical with Watasenia luciferin. +"2.8.2.11",Also acts on lactosylceramide. +"2.8.2.14","The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species [3]. This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. In addition to the 5beta-bile acid glycolithocholate, deoxycholate, 3beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) also act as substrates [see also EC 2.8.2.2 (alcohol sulfotransferase) and EC 2.8.2.34 (glycochenodeoxycholate sulfotransferase)]. May be identical to EC 2.8.2.2 [3]." +"2.8.2.15","Broad specificity resembling EC 2.8.2.2 alcohol sulfotransferase, but also acts on estrone." +"2.8.2.16","Also acts on dithiols; substrates include glutathione, dithioerythritol and 2,3-bis(sulfanyl)propan-1-ol." +"2.8.2.17",The sulfation is at the 6-position of N-acetylgalactosamine residues of chondroitin. Not identical with EC 2.8.2.5 chondroitin 4-sulfotransferase. +"2.8.2.20",The tyrosine residues of some specific proteins of rat pheochromocytoma cells act as acceptors. +"2.8.2.21","Sulfation takes place at the 6-position of galactosyl and N-acetylglucosaminyl residues in keratan, a proteoglycan. Not identical with EC 2.8.2.5 (chondroitin 4-sulfotransferase), EC 2.8.2.6 (choline sulfotransferase) or EC 2.8.2.17 (chondroitin 6-sulfotransferase)." +"2.8.2.22","The enzyme, characterized from bacteria that colonize the human and mouse intestine, catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. Activity is enhanced by Mg2+ and Mn2+ [1]. Unlike EC 2.8.2.9, tyrosine-ester sulfotransferase and EC 2.8.2.1, aryl sulfotransferase, the enzyme does not act on 3'-phosphoadenylyl sulfate or adenosine 3',5'-bisphosphate [1].The level of sulfation of polyphenols depends on the positions of the hydroxyl groups [3-5]. Hydroxy groups of tyrosine residues in peptides such as angiotensin can also act as acceptors [2]. The reaction proceeds according to a ping pong bi bi mechanism [6]." +"2.8.2.23","This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases [EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2) and EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3)] by being the most selective for a precursor of the antithrombin-binding site. It has a minimal acceptor sequence of: -> GlcNAc6S-> GlcA-> GlcN2S*+/-6S-> IdoA2S-> GlcN2S-> , the asterisk marking the target (symbols as in {iupac/2carb/38::2-Carb-38}) using +/- to mean the presence or absence of a substituent, and > to separate a predominant structure from a minor one. Thus Glc(N2S > NAc) means a residue of glucosamine where the N carries a sulfo group mainly but occasionally an acetyl group. [1-4]. It can also modify other precursor sequences within heparan sulfate but this action does not create functional antithrombin-binding sites. These precursors are variants of the consensus sequence: -> Glc(N2S > NAc)+/-6S-> GlcA-> GlcN2S*+/-6S-> GlcA > IdoA+/-2S-> Glc(N2S/NAc)+/-6S-> [5]. If the heparan sulfate substrate lacks 2-O-sulfation of GlcA residues, then enzyme specificity is expanded to modify selected glucosamine residues preceded by IdoA as well as GlcA [6]." +"2.8.2.24","This enzyme, characterized from cruciferous plants, catalyses the last step in the biosynthesis of tryptophan- and phenylalanine-derived glucosinolates. cf. EC 2.8.2.38, aliphatic desulfoglucosinolate sulfotransferase." +"2.8.2.25",Also acts on some other flavonol aglycones. +"2.8.2.28","Quercetin 3,4'-bissulfate can also act as acceptor." +"2.8.2.29","This enzyme sulfates the residues marked with an asterisk in sequences containing at least -> IdoA2S-> GlcN*-> or -> GlcA2S-> GlcN*-> (symbols as in {iupac/2carb/38::2-Carb-38}). Preference for GlcN2S vs. unmodified GlcN has not yet been established. Additional structural features are presumably required for substrate recognition, since the 3-O-sulfated residue is of low abundance, whereas the above IdoA-containing sequence is quite abundant. This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases by modifying selected glucosamine residues preceded by GlcA2S; EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1) prefers GlcA or IdoA, whereas EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3) prefers IdoA2S." +"2.8.2.30","Two major substrates contain the tetrasaccharides: -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN*-> and -> undetermined 2-sulfo-uronic acid-> GlcN2S-> IdoA2S-> GlcN6S*-> (symbols as in 2-Carb-38) with modification of the N-unsubstituted glucosamine residue (shown with an asterisk) [1,4]. Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded. The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells [2]. There are two isozymes, known as 3-OST-3A and 3-OST-3B, which have identical catalytic domains but are encoded by different mammalian genes [3]. The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases. It is inefficient at modifying precursors of the antithrombin binding site [in contrast to EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1)] and it does not modify glucosamine preceded by GlcA2S [unlike EC 2.8.2.29 ([heparan sulfate]-glucosamine 3-sulfotransferase 2)]." +"2.8.2.31","The enzyme from the lamprey Petromyzon marinus can also use the corresponding 3-ketone as a substrate. It is stereoselective (5alpha-cholane) and regioselective, exhibiting a preference for an hydroxy group at C-24. The enzyme is inactive when allocholic acid, which has a carboxy group at C-24, is used as a substrate." +"2.8.2.32",The enzyme from the shark Heterodontus portusjacksoni is able to sulfate the C27 bile salts 5beta-scymnol (the natural bile salt) and 5alpha-cyprinol (the carp bile salt). Enzyme activity is activated by Mg2+ but inhibited by the product 5beta-scymnol sulfate. +"2.8.2.33","The enzyme is activated by divalent cations and reduced glutathione. The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate and dermatan sulfate. Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not. Differs from EC 2.8.2.17, chondroitin 6-sulfotransferase, in being able to use both chondroitin and dermatan as effective substrates" +"2.8.2.34","The enzyme specifically sulfates glycochenodeoxycholate at the 7alpha-position (see also EC 2.8.2.14 bile-salt sulfotransferase). The monohydroxy bile acids glycolithocholate, chenodeoxycholate and ursodeoxycholate act as inhibitors." +"2.8.3.1",Butanoate and lactate can also act as acceptors. +"2.8.3.3",The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 4.1.1.9 malonyl-CoA decarboxylase. +"2.8.3.5","Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA." +"2.8.3.6","The enzyme, often found in soil bacteria and fungi, is involved in the catabolism of a variety of aromatic compounds, including catechol and protocatechuate, which are degraded via 3-oxoadipate." +"2.8.3.7",Itaconate can also act as acceptor. +"2.8.3.8","The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC 2.8.3.9, butyrate---acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA." +"2.8.3.9","Butanoate, acetoacetate and their CoA thioesters are the preferred substrates, but the enzyme also acts, more slowly, on the derivatives of a number of C2 to C6 monocarboxylic acids." +"2.8.3.10",The enzyme is a component of EC 4.1.3.6 [citrate (pro-3S)-lyase]. Also catalyses the transfer of thioacyl carrier protein from its acetyl thioester to citrate. +"2.8.3.11",The enzyme is a component of EC 4.1.3.22 citramalate lyase. Also catalyses the transfer of thioacyl carrier protein from its acetyl thioester to citramalate. +"2.8.3.12","Glutarate, (R)-2-hydroxyglutarate, propenoate and propanoate, but not (Z)-glutaconate, can also act as acceptors." +"2.8.3.13","Malonyl-CoA can also act as donor, but more slowly." +"2.8.3.14","Propanoyl-CoA, acetyl-CoA, butanoyl-CoA and some other acyl-CoAs can act as substrates, but more slowly than 5-hydroxypentanoyl-CoA." +"2.8.3.15",Involved in anaerobic catabolism of toluene and is a strictly toluene-induced enzyme that catalyses the reversible regio- and enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA. The enzyme from Thauera aromatica is inactive when (R)-benzylsuccinate is replaced by (S)-benzylsuccinate. +"2.8.3.16",The enzyme from Oxalobacter formigenes can also catalyse the transfer of CoA from formyl-CoA to succinate. +"2.8.3.17","The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It forms a complex with EC 4.2.1.175, (R)-3-(aryl)lactoyl-CoA dehydratase." +"2.8.4.1","This enzyme catalyses the final step in methanogenesis, the biological production of methane. This important anaerobic process is carried out only by methanogenic archaea. The enzyme can also function in reverse, for anaerobic oxidation of methane.The enzyme requires the hydroporphinoid nickel complex coenzyme F430. Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. The sulfide sulfur can be replaced by selenium but not by oxygen. " +"2.9.1.1","A pyridoxal 5'-phosphate enzyme identified in Escherichia coli. Recognises specifically tRNASec-species. Binding of tRNASec also occurs in the absence of the seryl group. 2-Aminoacryloyl-tRNA, bound to the enzyme as an imine with the pyridoxal phosphate, is an intermediate in the reaction. Since the selenium atom replaces oxygen in serine, the product may also be referred to as L-selenoseryl-tRNASec. The symbol Sel has also been used for selenocysteine but Sec is preferred." +"3.1.1.1","Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters." +"3.1.1.2","Acts on many phenolic esters. The reactions of EC 3.1.8.1 aryldialkylphosphatase, were previously attributed to this enzyme. It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases [7,8]. The natural substrates of the paraoxonases are lactones [7,8], with (+/-)-5-hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate [8]." +"3.1.1.3","The enzyme is found in diverse organisms including animals, plants, fungi, and bacteria. It hydrolyses triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids. The enzyme is highly soluble in water and acts at the surface of oil droplets. Access to the active site is controlled by the opening of a lid, which, when closed, hides the hydrophobic surface that surrounds the active site. The lid opens when the enzyme contacts an oil-water interface (interfacial activation). The pancreatic enzyme requires a protein cofactor, namely colipase, to counteract the inhibitory effects of bile salts." +"3.1.1.4","Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+." +"3.1.1.7",Acts on a variety of acetic esters; also catalyses transacetylations. +"3.1.1.8",Acts on a variety of choline esters and a few other compounds. +"3.1.1.10",Also acts on cocaine and other tropine esters. +"3.1.1.13","A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts." +"3.1.1.14","Chlorophyllase has been found in higher plants, diatoms, and in the green algae Chlorella [3]. This enzyme forms part of the chlorophyll degradation pathway and is thought to take part in de-greening processes such as fruit ripening, leaf senescence and flowering, as well as in the turnover and homeostasis of chlorophyll [4]. This enzyme acts preferentially on chlorophyll a but will also accept chlorophyll b and pheophytins as substrates [5]. Ethylene and methyl jasmonate, which are known to accelerate senescence in many species, can enhance the activity of the hormone-inducible form of this enzyme [5]." +"3.1.1.17","Acts on a wide range of hexose-1,5-lactones. The hydrolysis of L-gulono-1,5-lactone was previously listed separately." +"3.1.1.20",Also hydrolyses ester links in other tannins. +"3.1.1.24",The enzyme acts on the product of EC 4.1.1.44 4-carboxymuconolactone decarboxylase. +"3.1.1.25","The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+." +"3.1.1.26","Also acts on 2,3-di-O-acyl-1-O-(6-O-alpha-D-galactosyl-beta-D-galactosyl)-D-glycerol, and phosphatidylcholine and other phospholipids." +"3.1.1.28",Acts on higher fatty acid (C6 to C18) esters of L-carnitine; highest activity is with O-decanoyl-L-carnitine. +"3.1.1.29","The enzyme acts on premature protein synthesis products that dissociate from stalled ribosomes, cleaving the peptidyl chains and restoring functionality to the tRNA. In most organisms mutants with limited Pth activity accumulate peptidyl-tRNAs, reducing the availability of uncharged tRNAs below the limit that is necessary for protein synthesis and impairing cell growth. Two distinct classes of the enzyme, Pth and Pth2, have been identified. While most enzymes can recognize and cleave N-acylated aminoacyl-tRNAs, they are not able to act on N-formyl-methionyl-tRNA." +"3.1.1.32",This enzyme has a much broader specificity than EC 3.1.1.4 phospholipase A2. Requires Ca2+. +"3.1.1.34","Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins." +"3.1.1.35","Also hydrolyses some other benzenoid 1,4-lactones." +"3.1.1.36",Limonoate is a triterpenoid. +"3.1.1.40","The enzyme will only hydrolyse those substrates based on the 2,4-dihydroxy-6-methylbenzoate structure that also have a free hydroxy group ortho to the depside linkage." +"3.1.1.41",Hydrolyses the acetyl ester bond on the 10-position of the antibiotic cephalosporin C. +"3.1.1.42","Also acts, more slowly, on isochlorogenate. No other substrates are known." +"3.1.1.43",Also catalyses alpha-aminoacyl transfer to a number of amine nucleophiles. +"3.1.1.46","The enzyme opens the A-ring-lactone of the triterpenoid deoxylimonic acid, leaving the D-ring-lactone intact." +"3.1.1.48",Hydrolyses the three ornithine ester bonds in fusarinine C. Also acts on N5-dinitrophenyl-L-ornithine methyl ester. +"3.1.1.50","Also acts on long-chain acylglycerol, but not diacyl- or triacylglycerols." +"3.1.1.51","Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil." +"3.1.1.53","Acts on free and glycosidically bound N-acetyl- or N-glycoloyl-neuraminic acid; acts mainly on the 4-O- and 9-O-acetyl groups. Also acts on some other O-acetyl esters, both cyclic and acyclic compounds, which are not sialic acids." +"3.1.1.54",The enzyme is highly specific. +"3.1.1.55","Not identical with EC 3.1.1.1 (carboxylesterase), EC 3.1.1.2 (arylesterase), EC 3.1.1.7 (acetylcholinesterase) or EC 3.1.1.8 (cholinesterase). The activity of the liver cytosol enzyme is highest with acetyl esters of aryl alcohols, and thioesters are also hydrolysed; the microsomal enzyme also hydrolyses some other negatively charged esters, with highest activity on esters of salicylate with long-chain alcohols." +"3.1.1.56","Acts on short-chain acyl esters of 4-methylumbelliferone, but not on naphthyl, indoxyl or thiocholine esters." +"3.1.1.57","The product is most likely the keto-form of 4-oxalomesaconate (as shown in the reaction) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC 5.3.2.8, 4-oxalomesaconate tautomerase [3]." +"3.1.1.59","Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters." +"3.1.1.60","Also acts on 4-nitrophenyl esters, with optimum chain-length C6 to C8." +"3.1.1.61","Hydrolyses the products of EC 2.1.1.77 (protein-L-isoaspartate(D-aspartate) O-methyltransferase), EC 2.1.1.78 (isoorientin 3'-O-methyltransferase), EC 2.1.1.80 (protein-glutamate O-methyltransferase) and EC 2.1.1.100 (protein-S-isoprenylcysteine O-methyltransferase)." +"3.1.1.63",Activated by bile salts. +"3.1.1.64","This enzyme, which operates in the retinal pigment epithelium (RPE), catalyses the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle [4]. Interaction of the enzyme with the membrane is critical for its enzymic activity [6]." +"3.1.1.66",A highly specific enzyme from Tagetes patula. +"3.1.1.67","The reaction, forms ethyl esters from fatty acids and ethanol in the absence of coenzyme A or ATP. Best substrates are unsaturated octadecanoic acids; palmitate, stearate and arachidonate also act, but more slowly." +"3.1.1.70","Acts on a number of benzyl esters of substituted phenyl propanoates, and on the benzyl esters of phenylalanine and tyrosine." +"3.1.1.71","Hydrolysis of the acetyl group from the 1-alkyl-2-acetyl and 1-alkyl-3-acetyl substrates occurs at apparently identical rates. The enzyme from Erlich ascites cells is membrane-bound. It differs from lipoprotein lipase (EC 3.1.1.34) since 1,2-diacetyl-sn-glycerols are not substrates. It also differs from EC 3.1.1.47, 1-acetyl-2-alkyl-glycerophosphocholine esterase." +"3.1.1.72","Catalyses the hydrolysis of acetyl groups from polymeric xylan, acetylated xylose, acetylated glucose, alpha-napthyl acetate, p-nitrophenyl acetate but not from triacetylglycerol. Does not act on acetylated mannan or pectin." +"3.1.1.73","Catalyses the hydrolysis of the 4-hydroxy-3-methoxycinnamoyl (feruloyl) group from an esterified sugar, which is usually arabinose in ""natural"" substrates. p-Nitrophenol acetate and methyl ferulate are poorer substrates. All microbial ferulate esterases are secreted into the culture medium. They are sometimes called hemicellulase accessory enzymes, since they help xylanases and pectinases to break down plant cell wall hemicellulose." +"3.1.1.74","Cutin, a polymeric structural component of plant cuticles, is a polymer of hydroxy fatty acids that are usually C16 or C18 and contain up to three hydroxy groups. The enzyme from several fungal sources also hydrolyses the p-nitrophenyl esters of hexadecanoic acid. It is however inactive towards several esters that are substrates for non-specific esterases." +"3.1.1.75",Reaction also occurs with esters of other short-chain-length (C1-C5) hydroxyalkanoic acids (HA). There are two types of polymers: native (intracellular) granules are amorphous and have an intact surface layer; denatured (extracellular) granules either have no surface layer or a damaged surface layer and are partially crystalline. +"3.1.1.76","The main product after prolonged incubation is the dimer [3]. Besides hydrolysing polymers of 3-hydroxyoctanoic acid, the enzyme also hydrolyses other polymers derived from medium-chain-length (C6-C12) hydroxyalkanoic acids and copolymers of mixtures of these. It also hydrolyses p-nitrophenyl esters of fatty acids. Polymers of short-chain-length hydroxyalkanoic acids such as poly[(R)-3-hydroxybutanoic acid] and poly[(R)-3-hydroxypentanoic acid] are not hydrolysed." +"3.1.1.77","The substrate is lipid A on the reducing end of the toxic lipopolysaccharide (LPS) of Salmonella typhimurium and related organisms. It consists of diglucosamine, beta-D-GlcN-(1-> 6)-D-GlcN, attached by glycosylation on O-6 of its non-reducing residue, phosphorylated on O-4 of this residue and on O-1 of its potentially reducing residue. Both residues carry 3-(acyloxy)acyl groups on N-2 and O-3. The enzyme from human leucocytes detoxifies the lipid by hydrolysing the secondary acyl groups from O-3 of the 3-hydroxyacyl groups on the disaccharide (LPS). It also possesses a wide range of phospholipase and acyltransferase activities [e.g. EC 3.1.1.4 (phospholipase A2), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.32 (phospholipase A1) and EC 3.1.1.52 (phosphatidylinositol deacylase)], hydrolysing diacylglycerol and phosphatidyl compounds, but not triacylglycerols. It has a preference for saturated C12-C16 acyl groups." +"3.1.1.78",Following hydrolysis of this indole alkaloid ester the carboxylic acid decarboxylates spontaneously giving the sarpagan skeleton. The enzyme also acts on akuammidine aldehyde (the 16-epimer of polyneuridine aldehyde). +"3.1.1.79","This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) [2,3,4] as well as cholesteryl esters [2,4], steroid fatty acid esters [5], retinyl esters [6] and p-nitrophenyl esters [4,7]. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond [8]. The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP." +"3.1.2.2",Also hydrolyses CoA thioesters of other long-chain fatty acids. +"3.1.2.4",Also hydrolyses 3-hydroxypropanoyl-CoA. +"3.1.2.6","Also hydrolyses S-acetoacetylglutathione, but more slowly." +"3.1.2.12","Also hydrolyses S-acetylglutathione, but more slowly." +"3.1.2.14","Acts on acyl-carrier-protein thioesters of fatty acids from C12 to C18, but the derivative of oleic acid is hydrolysed much more rapidly than any other compound tested." +"3.1.2.15","Acts on esters formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin. May be the same as EC 3.4.19.12, ubiquitinyl hydrolase 1." +"3.1.2.16","In the proteobacterium Rubrivivax gelatinosus, this enzyme modulates the activity of EC 4.1.3.6, citrate (pro-3S)-lyase, by converting it from its active acetyl form into its inactive thiol form by removal of its acetyl groups [2]. The activity of citrate-lyase deacetylase is itself inhibited by L-glutamate [2]." +"3.1.2.18",Requires ADP; inhibited by NADH. Maximum activity is shown with propanoyl-CoA. +"3.1.2.19",Requires ADP; inhibited by NADH. Maximum activity is shown with nonanoyl-CoA. +"3.1.2.20",Broad specificity for medium- to long-chain acyl-CoA. Insensitive to NAD+ (cf. EC 3.1.2.19 ADP-dependent medium-chain-acyl-CoA hydrolase) +"3.1.2.21","Acts on the acyl-carrier-protein thioester of C12 and, with a much lower activity, C14 fatty acids. The derivative of oleic acid is hydrolysed very slowly (cf. EC 3.1.2.14, oleoyl-[acyl-carrier-protein] hydrolase)." +"3.1.2.22","Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA." +"3.1.2.23","This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway." +"3.1.2.25","This is the second step in the conversion of phenylacetyl-CoA to phenylglyoxylate, the first step being carried out by EC 1.17.5.1, phenylacetyl-CoA dehydrogenase." +"3.1.2.26","Choloyl-CoA, 3-dehydrocholoyl-CoA and chenodeoxycholoyl-CoA can also act as substrates, but acetyl-CoA, isovaleryl-CoA, palmitoyl-CoA and phenylacetyl-CoA cannot." +"3.1.2.27","Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoAs, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoAs, all of which are present in peroxisomes. The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome [1]." +"3.1.3.1",Wide specificity. Also catalyses transphosphorylations. The human placental enzyme is a zinc protein. Some enzymes hydrolyse diphosphate (cf. EC 3.6.1.1 inorganic diphosphatase) +"3.1.3.2",Wide specificity. Also catalyses transphosphorylations. +"3.1.3.4","This enzyme catalyses the Mg2+-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol. In lipid signalling, the enzyme generates a pool of DAG to be used for protein kinase C activation. The mammalian enzymes are known as lipins." +"3.1.3.5",Wide specificity for 5'-nucleotides. +"3.1.3.6",Wide specificity for 3'-nucleotides. +"3.1.3.7","Also acts on 3'-phosphoadenylyl sulfate, and on the corresponding 2'-phosphates." +"3.1.3.9","Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)]." +"3.1.3.10","Also acts, more slowly, on D-galactose 1-phosphate." +"3.1.3.11","The animal enzyme also acts on sedoheptulose 1,7-bisphosphate." +"3.1.3.16","A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase)." +"3.1.3.21","The Dunaliella enzyme acts more rapidly on sn-glycerol 1-phosphate than on the 3-phosphate. The enzyme from yeast also acts on propane-1,2-diol 1-phosphate, but not on a variety of other phosphate esters." +"3.1.3.23","Has a wide specificity, acting on aldohexose 1-phosphates, ketohexose 1-phosphates, aldohexose 6-phosphates, ketohexose 6-phosphates, both phosphate ester bonds of fructose 1,6-bisphosphate, phosphoric esters of disaccharides, and on pentose and triose phosphates, but at a slower rate." +"3.1.3.24","Requires Mg2+ for maximal activity [2]. This is the final step in the sucrose-biosynthesis pathway. The enzyme is highly specific for sucrose 6-phosphate, with fructose 6-phosphate unable to act as a substrate [2]. Belongs in the haloacid dehydrogenase (HAD) superfamily. The F of sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent." +"3.1.3.25","Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. It also acts on adenosine 2'-phosphate (but not the 3'- or 5'- phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate. Two isoforms are known [4]." +"3.1.3.28","Also acts on 2,3-bisphosphoglycerate." +"3.1.3.29","The enzyme, found in vertebrates, is equally active with N-acetylneuraminate 9-phosphate and N-glycoloylneuraminate 9-phosphate." +"3.1.3.31","A wide specificity for 2', 3'- and 5'- nucleotides; also hydrolyses glycerol phosphate and 4-nitrophenyl phosphate." +"3.1.3.32","Also hydrolyses nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides." +"3.1.3.33",Does not act on nucleoside monophosphates. Induced in Escherichia coli by T-even phages. +"3.1.3.34",Also catalyses the selective removal of 3'-phosphate groups from DNA and oligodeoxyribonucleotides. Induced in Escherichia coli by T-even phages. +"3.1.3.35","Acts on 5-methyl-dCMP and on TMP, but more slowly than on dTMP." +"3.1.3.36","These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase." +"3.1.3.38","Wide specificity, but 3-phosphoglycerate is the best substrate." +"3.1.3.39","Also acts on dihydrostreptomycin 3'alpha,6-bisphosphate and streptidine 6-phosphate." +"3.1.3.41","A number of other substances, including phenyl phosphate, 4-nitrophenyl sulfate, acetyl phosphate and glycerol phosphate, are not substrates." +"3.1.3.42",The product is EC 2.4.1.11 glycogen(starch) synthase. +"3.1.3.43","A mitochondrial enzyme associated with EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring), in the pyruvate dehydrogenase complex." +"3.1.3.44","Simultaneously dephosphorylates and activates EC 6.4.1.2 acetyl-CoA carboxylase. Acts similarly on EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase), EC 2.4.1.1 (phosphorylase), EC 2.4.1.11 [glycogen(starch) synthase], and dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate. Not identical to EC 3.1.3.17 ([phosphorylase] phosphatase ) or EC 3.1.3.43 {[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase}." +"3.1.3.46","The enzyme copurifies with EC 2.7.1.105 6-phosphofructo-2-kinase. (cf. EC 3.1.3.54 fructose-2,6-bisphosphate 6-phosphatase)." +"3.1.3.47","Acts on the product of the reaction catalysed by EC 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, simultaneously dephosphorylating and activating EC 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)." +"3.1.3.48","Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase." +"3.1.3.49","Simultaneously dephosphorylates and activates EC 2.7.1.40 pyruvate kinase, that has been inactivated by protein kinase." +"3.1.3.50","Acts, very slowly, on hexose 6-phosphates." +"3.1.3.52","A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. Simultaneously dephosphorylates and activates EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), that has been inactivated by phosphorylation." +"3.1.3.53","The enzyme is composed of three subunits. The holoenzyme dephosphorylates myosin light chains and EC 2.7.11.18, myosin-light-chain kinase, but not myosin; the catalytic subunit acts on all three substrates." +"3.1.3.54","cf. EC 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase." +"3.1.3.55",Dephosphorylation activates the calmodulin- and actin-binding ability of the protein caldesmon. +"3.1.3.56","One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids." +"3.1.3.57","The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate." +"3.1.3.58","Acts on sugars and polyols phosphorylated on the terminal carbon, with a preference for sugars with a D-erythro-configuration, e.g. good substrates are glucose 6-phosphate, mannose 6-phosphate, 6-phosphogluconate, erythrose 4-phosphate and xylitol 5-phosphate." +"3.1.3.59",Involved in the biosynthesis of thrombocyte activating factor in animal tissues. +"3.1.3.60","Also acts, but more slowly, on a wide range of other monophosphates." +"3.1.3.62","This ubiquitous enzyme degrades myo-inositol hexakisphosphate (phytate) to Ins(2,3)P2 and Ins(2)P. Activities have been characterized in the yeast Saccharomyces cerevisiae [2], the plant Lupinus albus [3] and the bacteria Bacillus sp. [4] and Raoultella terrigena [5]. In mammal cells Ins(2,3)P2 and Ins(2)P are the major inositol phosphate compounds found [6]. The mammal enzyme is also active on Ins(1,3,4,5,6)P5 that is dephosphorylated to Ins(1,4,5,6)P4 and Ins(1,4,5)P3, and on 2,3-bisphospho-D-glycerate (cf. EC 3.1.3.80, 2,3-bisphosphoglycerate 3-phosphatase). In addition, it acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3 in vitro (cf. EC 3.1.3.67, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase) [7]. It does not hydrolyse phosphates from the 2-positions of inositol phosphates [6]. In other organisms the degradation of phytate follows different routes. (cf. EC 3.1.3.8, 3-phytase, EC 3.1.3.26, 4-phytase, and EC 3.1.3.72, 5-phytase)." +"3.1.3.64","This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P2 to Ins-1-P." +"3.1.3.66","Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P." +"3.1.3.67","Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3" +"3.1.3.68",Also active towards fructose 1-phosphate +"3.1.3.69","Acts with EC 2.4.1.213 (glucosylglycerol-phosphate synthase) to form glucosylglycerol, an osmolyte that endows cyanobacteria with resistance to salt." +"3.1.3.70",Requires Mg2+. The enzyme from Pyrococcus horikoshii is specific for alpha-D-mannosyl-3-phosphoglycerate and forms part of the pathway for the synthesis of mannosylglycerate. +"3.1.3.71","Requires Mg2+. The enzyme from Methanococcus jannaschii acts on both stereoisoimers of the substrate and also hydrolyses a number of phosphate monoesters of (S)-2-hydroxycarboxylic acids, including 2-phosphomalate, 2-phospholactate and 2-phosphoglycolate. This enzyme can also hydrolyse phosphate monoesters of (R)-2-hydroxycarboxylic acids such as (S)-2-phospho-3-sulfolactate and (R)-2-phosphomalate, which, presumably, bind to the enzyme in opposite orientations." +"3.1.3.72","The enzyme attacks the product of the above reaction more slowly to yield Ins(1,2,3)P3." +"3.1.3.73","This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [3].It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [1]." +"3.1.3.74","Requires Mg2+. This enzyme is specific for phosphorylated vitamin B6 compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate. This reaction can also be carried out by EC 3.1.3.1 (alkaline phosphatase) and EC 3.1.3.2 (acid phosphatase), but these enzymes have very broad substrate specificities." +"3.1.3.75","Requires active site Mg2+ but also works, to a lesser extent, with Co2+ and Mn2+. The enzyme is highly specific for phosphoethanolamine and phosphocholine." +"3.1.4.1",Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides. A 3'-phosphate terminus on the substrate inhibits hydrolysis. +"3.1.4.2",Also acts on sn-glycero-3-phosphoethanolamine. +"3.1.4.3","The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol." +"3.1.4.4",Also acts on other phosphatidyl esters. +"3.1.4.11","These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four beta-isoforms regulated by G-proteins, two gamma-forms regulated by tyrosine kinases, four delta-forms regulated at least in part by calcium and an epsilon-form, probably regulated by the oncogene ras, have been found." +"3.1.4.12",Has very little activity on phosphatidylcholine. +"3.1.4.13",Acts only on those phosphodiesters that have ethanolamine as a component part of the molecule. +"3.1.4.14","The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [3]. Deletion of the gene encoding this enzyme abolishes ACP cofactor turnover in vivo [3]. Activation of apo-ACP to form the holoenzyme is carried out by EC 2.7.8.7, holo-[acyl-carrier-protein] synthase. " +"3.1.4.16","Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides. Similar reactions are carried out by EC 4.6.1.24 (ribonuclease T1) and EC 4.6.1.18 (pancreatic ribonuclease)." +"3.1.4.17","Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP." +"3.1.4.37","The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase." +"3.1.4.38",No activity on sn-3-glycerophosphoethanolamine. +"3.1.4.39",Also acts on acyl and choline analogues. +"3.1.4.41","Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate." +"3.1.4.42","Acts on both stereoisomers of the substrate and also, more slowly, on 3',5'-cyclic AMP and on 2',3'-cyclic AMP." +"3.1.4.43","This enzyme also hydrolyses Ins(cyclic1,2)P to Ins-1-P" +"3.1.4.45","Acts on a variety of compounds in which N-acetyl-D-glucosamine is alpha-linked to a phosphate group, including the biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes and the products of EC 2.7.8.17 UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase." +"3.1.4.46","Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis(glycerophospho)-glycerol are hydrolysed." +"3.1.4.50","This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes." +"3.1.4.51",The enzyme is specific for the product of EC 2.7.8.19 UDP-glucose---glycoprotein glucose phosphotransferase. +"3.1.5.1",Also acts on GTP. +"3.1.6.1","Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities. The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate. This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC 1.8.3.7, formylglycine-generating enzyme, EC 1.1.98.7, serine-type anaerobic sulfatase-maturating enzyme, or EC 1.8.98.7, cysteine-type anaerobic sulfatase-maturating enzyme." +"3.1.6.2",Also acts on some related steryl sulfates. +"3.1.6.3",Also acts on other sulfates of monosaccharides and disaccharides and on adenosine 5'-sulfate. +"3.1.6.8",Hydrolyses galactose-3-sulfate residues in a number of lipids. Also hydrolyses ascorbate 2-sulfate and many phenol sulfates. +"3.1.6.9","Also acts on the saturated analogue but not on higher oligosaccharides, nor any 6-sulfates." +"3.1.6.10","Also acts on the saturated analogue and N-acetyl-D-galactosamine 4,6-disulfate, but not higher oligosaccharides, nor any 4-sulfate" +"3.1.6.11",May be identical with EC 3.1.6.14 N-acetylglucosamine-6-sulfatase. +"3.1.6.12",Acts also on N-acetylglucosamine 4-sulfate. +"3.1.6.14",May be identical with EC 3.1.6.11 disulfoglucosamine-6-sulfatase. +"3.1.6.15",The enzyme from Flavobacterium heparinum also hydrolyses N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts only on the disulfated residue. +"3.1.6.16","Highly specific; does not act on monoethyl sulfate, monoisopropyl sulfate or monododecyl sulfate." +"3.1.6.17",Highly specific. +"3.1.6.18",Does not act on iduronate 2-sulfate residues (cf. EC 3.1.6.13 iduronate-2-sulfatase) +"3.1.7.1",Farnesyl diphosphate is the best substrate tested to date. +"3.1.7.3",A group of enzymes with varying specificity for the monoterpenol moiety. One has the highest activity on sterically hindered compounds such as (+)-bornyl diphosphate; another has highest activity on the diphosphates of primary allylic alcohols such as geraniol. +"3.1.8.1",Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase. +"3.1.8.2",Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase. +"3.1.11.1",Preference for single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA. +"3.1.11.2",Preference for double-stranded DNA. Has endonucleolytic activity near apurinic sites on DNA. +"3.1.11.3",Preference for double-stranded DNA. Does not attack single-strand breaks. +"3.1.11.4",Preference for single-stranded DNA. +"3.1.11.5",Preference for double-stranded DNA. Possesses DNA-dependent ATPase activity. Acts endonucleolytically on single-stranded circular DNA. +"3.1.11.6",Preference for single-stranded DNA. +"3.1.13.1","Preference for single-stranded RNA. The enzyme processes 3'-terminal extra-nucleotides of monomeric tRNA precursors, following the action of EC 3.1.26.5 ribonuclease P." +"3.1.13.2",This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13 (retroviral ribonuclease H). +"3.1.13.3",Also hydrolyses NAD+ to NMN and AMP. +"3.1.13.4",Cleaves poly(A) in either the single- or double-stranded form. +"3.1.14.1",Similar enzyme: RNase U4. +"3.1.15.1",Preference for single-stranded substrate. +"3.1.16.1",Preference for single-stranded substrate. +"3.1.21.1",Preference for double-stranded DNA. +"3.1.21.2","The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites. It specifically cleaves the DNA backbone at AP sites and also removes 3' DNA-blocking groups such as 3' phosphates, 3' phosphoglycolates, and 3' alpha,beta-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes. It is also the only known repair enzyme that is able to cleave the DNA backbone 5' of the oxidative lesion alpha-deoxyadenosine. The enzyme has a strong preference for single-stranded DNA." +"3.1.21.3","This is a large group of enzymes which, together with those now listed as EC 3.1.21.4 (type II site-specific deoxyribonuclease) and EC 3.1.21.5 (type III site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC 3.1.23 and EC 3.1.24. They have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. They are multifunctional proteins that also catalyse the reactions of EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] and EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase]." +"3.1.21.4","This is a large group of enzymes which, together with those now listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease) and EC 3.1.21.5." +"3.1.21.5","This is a large group of enzymes which, together with those now listed as EC 3.1.21.3 (type I site-specific deoxyribonuclease) and EC 3.1.21.4 (type II site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC 3.1.23 and EC 3.1.24. They have an absolute requirement for ATP but do not hydrolyse it; S-adenosy-L-methionine stimulates the reaction, but is not absolutely required. They recognize specific, short DNA sequences and cleave a short distance away from the recognition sequence. These enzymes exist as complexes with enzymes of similar specificity listed under EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] or EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase]." +"3.1.21.6","Prefers CC sites in double-stranded circular and linear DNA. Greater affinity for double-stranded than single-stranded DNA. Produces nicks, generating double-stranded fragments with 5'- and/or 3'-protruding single-stranded tails. Requires magnesium ions for activity. The endonuclease from Chlorella-like green algae infected with NYs-1 virus 4[1] may be the same enzyme." +"3.1.21.7",Previously classified erroneously as EC 3.1.22.3. +"3.1.22.1",Preference for double-stranded DNA. +"3.1.22.2",Preference for single-stranded DNA. +"3.1.22.4",The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions. +"3.1.22.5","Preference for supercoiled DNA; little activity on linear double-stranded DNA. Inhibited by single-stranded DNA, ATP and AMP." +"3.1.25.1","Acts on a damaged strand, 5' from the damaged site. " +"3.1.26.2",Specific for O-methylated RNA. +"3.1.26.3","This is an endoribonuclease that cleaves double-stranded RNA molecules [4]. The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site [5]. Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage [6]. RNase III is involved in both rRNA processing and mRNA processing and decay." +"3.1.26.4",Acts on RNA-DNA hybrids. +"3.1.26.5","An RNA-containing enzyme, essential for tRNA processing; generates 5'-termini or mature tRNA molecules." +"3.1.26.6",Forms oligonucleotides with an average chain length of 10. +"3.1.26.8","Converts the 5S-rRNA precursor from Bacillus subtilis into 5S-rRNA, with 5'-phosphate and 3'-hydroxy groups." +"3.1.26.9",Forms oligonucleotides with chain lengths of 6 to 12. +"3.1.26.10","Acts on poly(U) and poly(C), with a higher affinity for poly(C), but does not act on poly(A) or poly(G)." +"3.1.26.11",No cofactor requirements. An homologous enzyme to that found in Arabidopsis thaliana has been found in Methanococcus janaschii. +"4.2.3.197",Isolated from the plant Zea mays (maize). The product is named in the reference using a different numbering scheme for eudesmane. +"3.1.27.3",Formerly EC 2.7.7.26 and EC 3.1.4.8. +"4.2.3.196","The enzyme, which has been characterized from maize, is involved in the biosynthesis of dolabralexins (type of antifungal phytoalexins)." +"3.1.27.8",Also hydrolyses poly(U). +"3.1.27.9",The enzyme catalyses the final stage in the maturation of tRNA molecules. +"3.1.27.10",Also acts on bacterial rRNA. +"3.1.30.2",Hydrolyses double- or single-stranded substrate. +"3.1.31.1",Hydrolyses double- or single-stranded substrate. +"3.2.1.1","Acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration. The term ""alpha"" relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolysed." +"3.2.1.2","Acts on starch, glycogen and related polysaccharides and oligosaccharides producing beta-maltose by an inversion. The term 'beta'' relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolysed." +"3.2.1.3","Most forms of the enzyme can rapidly hydrolyse 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyse 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides. This entry covers all such enzymes acting on polysaccharides more rapidly than on oligosaccharides. EC 3.2.1.20 alpha-glucosidase, from mammalian intestine, can catalyse similar reactions." +"3.2.1.4","Will also hydrolyse 1,4-linkages in beta-D-glucans also containing 1,3-linkages." +"3.2.1.6","Substrates include laminarin, lichenin and cereal D-glucans; different from EC 3.2.1.52 beta-N-acetylhexosaminidase." +"3.2.1.10","This enzyme, like EC 3.2.1.33 (amylo-alpha-1,6-glucosidase), can release an alpha-1->6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41 (pullulanase), EC 3.2.1.142 (limit dextrinase), and EC 3.2.1.68 (isoamylase) is maltose. It also hydrolyses isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin. The enzyme from intestinal mucosa is a single polypeptide chain that also catalyses the reaction of EC 3.2.1.48 (sucrose alpha-glucosidase). Differs from EC 3.2.1.33 (amylo-alpha-1,6-glucosidase) in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4." +"3.2.1.14","The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo-chitodextrinases can act. Activity is greatly stimulated in the presence of EC 1.14.99.53, lytic chitin monoxygenase, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. cf. EC 3.2.1.202, endo-chitodextrinase." +"3.2.1.15",The enzyme catalyses the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans. Different forms of the enzyme have different tolerances to methyl esterification of the substrate. +"3.2.1.17",cf. also EC 3.2.1.14 chitinase. +"3.2.1.18","The enzyme does not act on 4-O-acetylated sialic acids. endo-alpha-Sialidase activity is listed as EC 3.2.1.129, endo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase." +"3.2.1.20","This single entry covers a group of enzymes whose specificity is directed mainly towards the exohydrolysis of (1->4)-alpha-glucosidic linkages, and that hydrolyse oligosaccharides rapidly, relative to polysaccharide, which are hydrolysed relatively slowly, or not at all. The intestinal enzyme also hydrolyses polysaccharides, catalysing the reactions of EC 3.2.1.3 glucan 1,4-alpha-glucosidase and, more slowly, hydrolyses (1->6)-alpha-D-glucose links." +"3.2.1.21","Wide specificity for beta-D-glucosides. Some examples also hydrolyse one or more of the following: beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides." +"3.2.1.22",Also hydrolyses alpha-D-fucosides. +"3.2.1.23",Some enzymes in this group hydrolyse alpha-L-arabinosides; some animal enzymes also hydrolyse beta-D-fucosides and beta-D-glucosides; cf. EC 3.2.1.108 lactase. +"3.2.1.24","Also hydrolyses alpha-D-lyxosides and heptopyranosides with the same configuration at C-2, C-3 and C-4 as mannose." +"3.2.1.26",Substrates include sucrose; also catalyses fructotransferase reactions. +"3.2.1.28","The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha-trehalose, releasing initially equimolar amounts of alpha- and beta-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates." +"3.2.1.32","This enzyme is found mostly in marine bacteria, which break down the beta(1,3)-xylan found in the cell wall of some green and red algae. The enzyme produces mainly xylobiose, xylotriose and xylotetraose." +"3.2.1.33","This enzyme hydrolyses an unsubstituted glucose unit linked by an alpha(1->6) bond to an alpha(1->4) glucose chain. The enzyme activity found in mammals and yeast is in a polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25 (4-alpha-glucanotransferase), which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyse. Together, these two activities constitute the glycogen debranching system." +"3.2.1.35","Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan." +"3.2.1.37",Also hydrolyses xylobiose. Some other exoglycosidase activities have been found associated with this enzyme in sheep liver. +"3.2.1.38","Enzymes from some sources also hydrolyse beta-D-galactosides and/or beta-D-glucosides and/or alpha-L-arabinosides. The activity of EC 3.2.1.37 xylan 1,4-beta-xylosidase, is an associated activity found in some sources (e.g. liver)." +"3.2.1.39","Different from EC 3.2.1.6 endo-1,3(4)-beta-glucanase. Very limited action on mixed-link (1->3,1->4)-beta-D-glucans. Hydrolyses laminarin, paramylon and pachyman." +"3.2.1.40","The enzyme, found in animal tissues, plants, yeasts, fungi and bacteria, utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnose. Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnose." +"3.2.1.41","Different from EC 3.2.1.142 (limit dextrinase) in its action on glycogen, and its rate of hydrolysis of limit dextrins. Its action on amylopectin is complete. Maltose is the smallest sugar that it can release from an alpha-(1->6)-linkage." +"3.2.1.45",Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase). +"3.2.1.46",cf. EC 3.2.1.62 glycosylceramidase. +"3.2.1.48","This enzyme is isolated from intestinal mucosa as a single polypeptide chain that also displays activity towards isomaltose (EC 3.2.1.10 oligo-1,6-glucosidase)." +"3.2.1.49",The human lysosomal enzyme is involved in the degradation of blood type A epitope. +"3.2.1.50",Hydrolyses UDP-N-acetylglucosamine. +"3.2.1.52",Acts on N-acetylglucosides and N-acetylgalactosides. +"3.2.1.54",Also hydrolyses linear maltodextrin. +"3.2.1.55","The enzyme acts on alpha-L-arabinofuranosides, alpha-L-arabinans containing (1,3)- and/or (1,5)-linkages, arabinoxylans and arabinogalactans. Some beta-galactosidases (EC 3.2.1.23) and beta-D-fucosidases (EC 3.2.1.38) also hydrolyse alpha-L-arabinosides. cf. EC 3.2.1.185, non-reducing end beta-L-arabinofuranosidase." +"3.2.1.57",The enzyme has practically no action on starch. Panose (4-alpha-isomaltosylglucose) is hydrolysed to isomaltose and glucose. cf. EC 3.2.1.41 (pullulanase) and EC 3.2.1.135 (neopullulanase). +"3.2.1.58","Acts on oligosaccharides, but very slowly on laminaribiose." +"3.2.1.59","Products from pseudonigeran (1,3-alpha-D-glucan) are nigerose and alpha-D-glucose." +"3.2.1.60","Compare EC 3.2.1.2 beta-amylase, which removes successive maltose residues, and EC 3.2.1.98 (glucan 1,4-alpha-maltohexaosidase) and EC 3.2.1.116 (glucan 1,4-alpha-maltotriohydrolase)." +"3.2.1.61","Products are nigerose and 4-alpha-D-nigerosylglucose. No hydrolysis of alpha-D-glucans containing only 1,3- or 1,4-bonds." +"3.2.1.62","The enzyme, found in the intestinal mucosa, hydrolyses beta-D-glucosyl and beta-D-galactosyl residues from a very broad range of substrates using a retaining mechanism. Characterized substrates include glucosyl- and galactosyl-ceramides [3], O3-, O4'- and O7-glucosylated flavonoids [6], and the 2'-O-glucosylated dihydrochalcone phlorizin [1]. The enzyme includes two glycosyl hydrolase domains, both belonging to the GH1 family. While one domain is responsible for the activity described here, the other catalyses the reaction of EC 3.2.1.108, lactase [4,5]. cf. EC 3.2.1.45, glucosylceramidase and EC 3.2.1.46, galactosylceramidase." +"3.2.1.63","Highly specific for non-reducing terminal L-fucose residues linked to D-galactose residues by a 1,2-alpha-linkage. Not identical with EC 3.2.1.111 1,3-alpha-L-fucosidase." +"3.2.1.66",Quercitrin is quercetin 3-L-rhamnoside. +"3.2.1.67","The enzyme hydrolyses the first glycosidic bond from the non-reducing end of the substrate. It is specific for saturated oligomers of D-homogalacturonan, and is unable to degrade unsaturated substrates or methyl-esterified substrates." +"3.2.1.68","Also readily hydrolyses amylopectin. Differs from EC 3.2.1.41 (pullulanase) and EC 3.2.1.142 (limit dextrinase) by its inability to hydrolyse pullulan, and by limited action on alpha-limit dextrins. Maltose is the smallest sugar it can release from an alpha-(1->6)-linkage." +"3.2.1.70","Hydrolysis is accompanied by inversion at C-1, so that new reducing ends are released in the beta-configuration. Dextrans and isomaltosaccharides are hydrolysed, as is isomaltose, but very slowly. The enzyme from some sources also possesses the activity of EC 3.2.1.59 (glucan endo-1,3-alpha-glucosidase)." +"3.2.1.73","Acts on lichenin and cereal beta-D-glucans, but not on beta-D-glucans containing only 1,3- or 1,4-bonds." +"3.2.1.74","Acts on 1,4-beta-D-glucans and related oligosaccharides. Cellobiose is hydrolysed, but very slowly." +"3.2.1.75","Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides." +"3.2.1.77","A 1,6-alpha-D-mannan backbone remains after action on yeast mannan. This is further attacked, but slowly." +"3.2.1.80","Hydrolyses inulin and levan, and also sucrose." +"3.2.1.81","Also acts on porphyran, but more slowly [1]. This enzyme cleaves the beta-(1->4) linkages of agarose in a random manner with retention of the anomeric-bond configuration, producing beta-anomers that give rise progressively to alpha-anomers when mutarotation takes place [6]. The end products of hydrolysis are neoagarotetraose and neoagarohexaose in the case of AgaA from the marine bacterium Zobellia galactanivorans, and neoagarotetraose and neoagarobiose in the case of AgaB [6]." +"3.2.1.82","The enzyme, characterized from bacteria, hydrolyses the second alpha-1,4-glycosidic bond from the non-reducing end of polygalacturonate, releasing digalacturonate." +"3.2.1.83","The main products of hydrolysis are neocarrabiose-sulfate and neocarratetraose-sulfate [5]. Unlike EC 3.2.1.157 (iota-carrageenase), but similar to EC 3.2.1.81 (beta-agarase), this enzyme proceeds with retention of the anomeric configuration." +"3.2.1.84",Does not act on nigeran. +"3.2.1.86","Also hydrolyses several other phospho-beta-D-glucosides, but not their non-phosphorylated forms." +"3.2.1.87","Hydrolyses the galactosyl-alpha-1,3-D-galactose linkages only in the complex substrate, bringing about depolymerization." +"3.2.1.88","The enzyme, which was characterized from dormant seeds of the plant Cajanus cajan (pigeon pea), has been shown to remove the terminal non-reducing beta-L-arabinopyranoside residue from the artificial substrate p-nitrophenyl-beta-L-arabinopyranose [1]. In the presence of methanol the enzyme demonstrates transglycosylase activity, transferring the arabinose moiety to methanol while retaining the anomeric configuration, generating 1-O-methyl-beta-L-arabinopyranose [2]." +"3.2.1.89","This enzyme, isolated from the bacterium Bacillus subtilis, hydrolyses the beta(1->4) bonds found in type I plant arabinogalactans, which are a component of the primary cell walls of dicots. The predominant product is a tetrasaccharide. cf. EC 3.2.1.181, galactan endo-beta-1,3-galactanase." +"3.2.1.94","Optimum activity is on those 1,6-alpha-D-glucans containing 6, 7 and 8 glucose units; those containing 3, 4 and 5 glucose units are hydrolysed at slower rates." +"3.2.1.96",A group of related enzymes. +"3.2.1.97","The enzyme catalyses the liberation of Gal-(1->3)-beta-GalNAc alpha-linked to serine or threonine residues of mucin-type glycoproteins. EngBF from the bacterium Bifidobacterium longum specifically acts on core 1-type O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc. The enzymes from the bacteria Clostridium perfringens, Enterococcus faecalis, Propionibacterium acnes and Alcaligenes faecalis show broader specificity (e.g. they can also release the core 2 trisaccharide Gal-(1->3)-beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc-(1->3)-beta-GalNAc) [1,2]. The enzyme may play an important role in the degradation and utilization of mucins having core 1 O-glycan." +"3.2.1.98","cf. EC 3.2.1.3 glucan 1,4-alpha-glucosidase, which removes successive glucose residues; EC 3.2.1.2 beta-amylase, which removes successive maltose residues; EC 3.2.1.116 glucan 1,4-alpha-maltotriohydrolase, which removes successive maltotriose units and EC 3.2.1.60 glucan 1,4-alpha-maltotetraohydrolase, which removes successive maltotetraose residues. The products have the alpha-configuration." +"3.2.1.99","Acts best on linear 1,5-alpha-L-arabinan. Also acts on branched arabinan, but more slowly." +"3.2.1.102","Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to a 1,3-alpha-D-galactosyl or N-acetylgalactosaminyl residues and a 1,2-alpha-D-fucosyl residue." +"3.2.1.103","Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to 1,3-N-acetyl-alpha-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC 3.2.1.102 blood-group-substance endo-1,4-beta-galactosidase)." +"3.2.1.104","Acts on glucosides of cholesterol and sitosterol, but not on some related sterols such as coprostanol." +"3.2.1.105",Does not act on a number of closely related glycosides. Strictosidine is a precursor of indole alkaloids. +"3.2.1.106","This enzyme catalyses the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue. This and subsequent processing steps are required before complex N-glycans can be synthesized." +"3.2.1.107",The enzyme specifically hydrolyses glucose from alpha-D-glucosyl-(1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins. Acetylation of the epsilon-amino group of the glycosylated hydroxylysine abolishes activity. +"3.2.1.108","The enzyme from intestinal mucosa contains two glycosyl hydrolase domains, both of which belong to glycosyl hydrolase family 1 (GH1). While the first domain catalyses the activity described here, the second domain catalyses the reaction of EC 3.2.1.62 glycosylceramidase. cf. EC 3.2.1.33 amylo-alpha-1,6-glucosidase." +"3.2.1.111","Not identical with EC 3.2.1.63 1,2-alpha-L-fucosidase." +"3.2.1.113","This family of mammalian enzymes, located in the Golgi system, participates in the maturation process of N-glycans that leads to formation of hybrid and complex structures. The enzymes catalyse the hydrolysis of the four (1->2)-linked alpha-D-mannose residues from the Man9GlcNAc2 oligosaccharide attached to target proteins as described in reaction (1). Alternatively, the enzymes act on the Man8GlcNAc2 isomer formed by EC 3.2.1.209, endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase, as described in reaction (2). The enzymes are type II membrane proteins, require Ca2+, and use an inverting mechanism. While all three human enzymes can catalyse the reactions listed here, some of the enzymes can additionally catalyse hydrolysis in an alternative order, generating additional isomeric intermediates, although the final product is the same. The names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7]." +"3.2.1.114","The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine." +"3.2.1.115",Has a much lower activity with kojibiose and kojitriose. +"3.2.1.220","The enzyme, isolated from the roots of the plant Carapichea ipecacuanha, preferentially hydrolyses glucosidic ipecoside alkaloids except for their lactams, but shows poor or no activity toward other substrates. IpeGlu1 activity is extremely poor toward 7-O-methyl and 6,7-O,O-dimethyl derivatives. However, 6-O-methyl derivatives are hydrolysed as efficiently as non-methylated substrates. IpeGlu1 accepts both 1alpha(S)-N-deacetylisoipecoside and 1beta(R)-N-deacetylipecoside epimers as substrate, with preference for the 1beta(R)-epimer. 6-O-methyl-N-deacetylisoipecoside is an intermediate in the biosynthesis of the medicinal alkaloid emetine." +"3.2.1.116","cf. EC 3.2.1.2 (beta-amylase), EC 3.2.1.60 (glucan 1,4-alpha-maltotetraohydrolase) and EC 3.2.1.98 (glucan 1,4-alpha-maltohexaosidase). The products have the alpha-configuration." +"3.2.1.117","Highly specific; does not act on prunasin, linamarin, gentiobiose or cellobiose (cf. EC 3.2.1.21 beta-glucosidase)." +"3.2.1.118","Highly specific; does not act on amygdalin, linamarin or gentiobiose. (cf. EC 3.2.1.21 beta-glucosidase)." +"3.2.1.119","Also hydrolyses, more slowly, (R)-amygdalin and (R)-prunasin, but not gentiobiose, linamarin or cellobiose." +"3.2.1.121","Does not act on alginic acid, which is a copolymer of polymannuronate." +"3.2.1.122","Hydrolyses a variety of 6-phospho-alpha-D-glucosides, including alpha-maltose 6'-phosphate, alpha,alpha-trehalose 6-phosphate, sucrose 6-phosphate and p-nitrophenyl-alpha-D-glucopyranoside 6-phosphate (as a chromogenic substrate). The enzyme is activated by FeII, MnII, CoII and NiII. It is rapidly inactivated in air." +"3.2.1.123","An enzyme from Rhodococcus sp. that degrades various acidic and neutral glycosphingolipids to oligosaccharides and ceramides, by cleaving a glucosyl bond. Does not act on monoglycosylceramides. cf. EC 3.2.1.62 glycosylceramidase." +"3.2.1.124",The enzyme from a bacteriophage catalyses the depolymerization of capsular polysaccharides containing 3-deoxy-2-octulosonide in the cell wall of Escherichia coli. +"3.2.1.125","Highly specific; some other ajmalan glucoside alkaloids are hydrolysed, but more slowly." +"3.2.1.126","Also hydrolyses syringin, 4-cinnamyl alcohol beta-glucoside and, more slowly, some other aryl beta-glycosides. A plant cell-wall enzyme involved in the biosynthesis of lignin." +"3.2.1.127","The enzyme from Aspergillus niger does not act on 1,2-, 1,3-, or 1,4-L-fucosyl linkages." +"3.2.1.128",The enzyme from Aspergillus niger is specific for the hydrolysis of the triterpenoid glycoside glycyrrhizin from roots of Glycyrrhiza sp. +"3.2.1.129","Although the name endo-N-acetylneuraminidase has also been used for this enzyme, this is misleading since its activity is not restricted to acetylated substrates. An exo-alpha-sialidase activity is listed as EC 3.2.1.18 exo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase." +"3.2.1.130",The enzyme catalyses the hydrolysis of the terminal alpha-D-glucosyl-(1->3)-D-mannosyl unit from the GlcMan9(GlcNAc)2 oligosaccharide component of N-glucosylated proteins during their processing in the Golgi apparatus. The name for the isomer is based on a nomenclature proposed by Prien et al [7]. +"3.2.1.132","A whole spectrum of chitosanases are now known (for more details, see {http://rbrzezinski.recherche.usherbrooke.ca/::http://rbrzezinski.recherche.usherbrooke.ca/}). They can hydrolyse various types of links in chitosan. The only constant property is the endohydrolysis of GlcN-GlcN links, which is common to all known chitosanases. One known chitosanase is limited to this link recognition [4], while the majority can also recognize GlcN-GlcNAc links or GlcNAc-GlcN links but not both. They also do not recognize GlcNAc-GlcNAc links in partly acetylated chitosan." +"3.2.1.133",Acts on starch and related polysaccharides and oligosaccharides. The product is alpha-maltose; cf. EC 3.2.1.2 beta-amylase. +"3.2.1.134","The enzyme participates in an inulin degradation pathway, hydrolysing the product of EC 4.2.2.17, inulin fructotransferase (DFA-I-forming)." +"3.2.1.135",cf. EC 3.2.1.41 (pullulanase ) and EC 3.2.1.57 (isopullulanase). +"3.2.1.136",High activity towards feruloylated arabinoxylans from cereal plant cell walls. +"3.2.1.137","Mannose residues linked alpha-D-1,3- are also released, but very slowly." +"3.2.1.139",Considerable differences in the specificities of the enzymes from different fungi for alpha-D-glucosiduronates have been reported. Activity is also found in the snail. +"3.2.1.140","The enzyme from Streptomyces specifically hydrolyses the terminal lacto-N-biosyl residue (beta-D-Gal-(1->3)-D-GlcNAc) from the non-reducing end of oligosaccharides with the structure beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->R). Lacto-N-hexaose (beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc) is hydrolysed to form first lacto-N-tetraose plus lacto-N-biose, with the subsequent formation of lactose. Oligosaccharides in which the non-reducing terminal Gal or the penultimate GlcNAc are replaced by fucose or sialic acid are not substrates. Asialo GM1 tetraose (beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc) is hydrolysed very slowly, but lacto-N-neotetraose (beta-D-Gal-(1->4)-beta-D-GalNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc) is not a substrate." +"3.2.1.142","Plant enzymes with little or no action on glycogen. Action on amylopectin is incomplete, but action on alpha-limit dextrins is complete. Maltose is the smallest sugar it can release from an alpha-(1->6)-linkage." +"3.2.1.143",Specific to (1''-2') linkage of ribose-ribose bond of poly(ADP-D-ribose). +"3.2.1.144","Releases Kdo (alpha- and beta-linked 3-deoxy-D-manno-octulosonic acid) from different lipopolysaccharides, including Re-LPS from Escherichia coli and Salmonella, Rd-LPS from S. minnesota, and de-O-acyl-re-LPS. 4-Methylumbelliferyl-alpha-Kdo (alpha-Kdo-OMec) is also a substrate." +"3.2.1.145","This enzyme removes not only free galactose, but also 6-glycosylated residues, e.g., (1->6)-beta-D-galactobiose, and galactose bearing oligosaccharide chains on O-6. Hence, it releases branches from [arabino-galacto-(1->6)]-(1->3)-beta-D-galactans." +"3.2.1.146","The enzyme from Helminthosporium sacchari detoxifies helminthosporoside, a bis(digalactosyl)terpene produced by this fungus, by releasing its four molecules of bound galactose." +"3.2.1.147",Has a wide specificity for thioglycosides. +"3.2.1.149","The enzyme is responsible for the formation of the alcoholic aroma in oolong and black tea. In addition to beta-primeverosides [i.e. 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranosides], it also hydrolyses 6-O-(beta-D-apiofuranosyl)-beta-D-glucopyranosides and, less rapidly, beta-vicianosides and 6-O-(alpha-L-arabinofuranosyl)-beta-D-glucopyranosides, but not beta-glucosides. Geranyl-, linaloyl-, benzyl- and p-nitrophenol glycosides are all hydrolysed." +"3.2.1.150",The enzyme is found in the fungus Geotrichum sp. M128. The substrate is a hemicellulose found in plant cell walls. +"3.2.1.151","The enzyme from Aspergillus aculeatus is specific for xyloglucan and does not hydrolyse other cell-wall components. The reaction involves endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues." +"3.2.1.152","The substrate group is a substituent on N-4 of an asparagine residue in the glycoprotein. The mannose residue at the non-reducing end of the sequence may carry further alpha-D-mannosyl groups on O-3 or O-6, but such a substituent on O-3 of the beta-D-mannosyl group prevents the action of the enzyme. The enzyme was obtained from the lily, Lilium longiflorum." +"3.2.1.153","Possesses one of the activities of EC 3.2.1.80, fructan beta-fructosidase. While the best substrates are the inulin-type fructans, such as 1-kestose [beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside] and 1,1-nystose [beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside], some (but not all) levan-type fructans can also be hydrolysed, but more slowly [see EC 3.2.1.154, fructan beta-(2,6)-fructosidase]. Sucrose, while being a very poor substrate, can substantially inhibit enzyme activity in some cases." +"3.2.1.154","Possesses one of the activities of EC 3.2.1.80, fructan beta-fructosidase. While the best substrates are the levan-type fructans such as 6-kestotriose [beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranosyl alpha-D-glucopyranoside] and 6,6-kestotetraose [beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranosyl alpha-D-glucopyranoside], some (but not all) inulin-type fructans can also be hydrolysed, but more slowly [cf. EC 3.2.1.153, fructan beta-(2,1)-fructosidase]. Sucrose, while being a very poor substrate, can substantially inhibit enzyme activity in some cases." +"3.2.1.156","The enzyme, originally isolated from the bacterium Bacillus halodurans C-125, releases the xylose unit at the reducing end of oligosaccharides ending with the structure beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose, leaving the new reducing end in the alpha configuration. It is specific for the beta anomers of xylooligosaccharides whose degree of polymerization is equal to or greater than 3. +The penultimate residue must be beta-D-xylopyranose, but replacing either of the flanking residues with glucose merely slows the rate greatly." +"3.2.2.1","The enzyme from the bacterium Ochrobactrum anthropi specifically catalyses the irreversible N-riboside hydrolysis of purine nucleosides. Pyrimidine nucleosides, purine and pyrimidine nucleotides, NAD+, NADP+ and nicotinaminde mononucleotide are not substrates [6]." +"3.2.2.5","This enzyme catalyses the hydrolysis of NAD+, without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase). The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis. The enzyme from the venom of the snake Agkistrodon acutus also catalyses EC 3.6.1.5, apyrase [3]." +"3.2.2.6","This multiunctional enzyme acts on NAD+, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. It is also able to act on beta-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD+ glycohydrolase." +"3.2.2.7",Also acts on adenosine N-oxide. +"3.2.2.8","Also hydrolyses purine D-ribonucleosides, but much more slowly. 2'-, 3'- and 5'-deoxynucleosides are not substrates [3]." +"3.2.2.9","This enzyme, found in bacteria and plants, acts on three different substrates. It is involved in the S-adenosyl-L-methionine (SAM, AdoMet) cycle, which recycles S-adenosyl-L-homocysteine back to SAM, and in salvage pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are produced from SAM during the action of many enzymes. cf. the plant enzyme EC 3.2.2.16, methylthioadenosine nucleosidase." +"3.2.2.10","Also acts on dUMP, dTMP and dCMP." +"3.2.2.14","The enzyme is thought to participate in an NAD+-salvage pathway. In eukaryotic organisms this activity has been attributed to EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase." +"3.2.2.16","Unlike EC 3.2.2.9, adenosylhomocysteine nucleosidase, this plant enzyme has little or no activity with S-adenosyl-L-homocysteine. " +"3.2.2.19",The enzyme will remove ADP-D-ribose from arginine residues in ADP-ribosylated proteins. +"3.2.2.20",Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA---[protein]-cysteine S-methyltransferase). +"3.2.2.21",Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA---[protein]-cysteine S-methyltransferase). +"3.2.2.22",Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position. +"3.2.2.23","May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA." +"3.2.2.24","The enzyme restores the activity of EC 1.18.6.1, nitrogenase, by catalysing the removal of ADP-ribose from an arginine residue of the dinitrogenase reductase component of nitrogenase. This activity occurs only when the nitrogenase product, ammonium, is not available. The combined activity of this enzyme and EC 2.4.2.37, NAD+---dinitrogen-reductase ADP-D-ribosyltransferase, controls the level of activity of nitrogenase." +"3.3.1.1","The enzyme contains one tightly bound NAD+ per subunit. This appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond [2] (for mechanism, click here), cf. EC 5.5.1.4, inositol-3-phosphate synthase." +"3.3.1.2","Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC 3.13.1.8, S-adenosyl-L-methionine hydrolase (adenosine-forming)." +"3.3.2.1","The enzyme is involved in the biosynthesis of several siderophores, such as 2,3-dihydroxybenzoylglycine, enterobactin, bacillibactin, and vibriobactin." +"3.3.2.2","Lysoplasmalogenase is specific for the sn-2-deacylated (lyso) form of plasmalogen and catalyses hydrolytic cleavage of the vinyl ether bond, releasing a fatty aldehyde and sn-glycero-3-phosphocholine or sn-glycero-3-phosphoethanolamine." +"3.3.2.3",Acts on a variety of epoxides and arene oxides. Formerly EC 4.2.1.63 and EC 4.2.1.64. +"3.3.2.4",Acts on both optical isomers of the substrate. +"3.3.2.6","This is a bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities [4,6]. It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates [6] (see EC 3.4.11.6, aminopeptidase B). It also converts leukotriene A4 into leukotriene B4, unlike EC 3.3.2.10, soluble epoxide hydrolase, which converts leukotriene A4 into 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid [3,4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase) [5]." +"1.14.14.10","Requires Mg2+. The enzyme from Aminobacter aminovorans (previously Chelatobacter heintzii) is part of a two component system that also includes EC 1.5.1.42 (FMN reductase), which provides reduced flavin mononucleotide for this enzyme." +"3.3.2.7","Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide [2]. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3]." +"3.3.2.8","Involved in the monoterpene degradation pathway of the actinomycete Rhodococcus erythropolis. The enzyme hydrolyses several alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. It differs from the previously described epoxide hydrolases [EC 3.3.2.4 (trans-epoxysuccinate hydrolase), EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase) and EC 3.3.2.10 (soluble epoxide hydrolase)] as it is not inhibited by 2-bromo-4'-nitroacetophenone, diethyl dicarbonate, 4-fluorochalcone oxide or 1,10-phenanthroline. Both enantiomers of menth-8-ene-1,2-diol [i.e. (1R,2R,4S)-menth-8-ene-1,2-diol and (1S,2S,4R)-menth-8-ene-1,2-diol] are metabolized." +"3.5.1.3","Acts on glutaramate, succinamate and their 2-oxo derivatives." +"3.5.1.5","A nickel protein. Urease catalyses the hydrolysis of urea to yield ammonia and carbamate, which spontaneously hydrolyses to form carbonic acid and a second molecule of ammonia. In aqueous solutions the products convert to ammonium and hydrogen carbonate. The enzyme is widespread and is found in many bacteria, some archaea, and many eukaryotes, including plants, some invertebrates, and numerous eukaryotic microorganisms. Urease is one of the earlier enzymes to be studied, first obtained In 1874 [1,2], and named urease in 1890 [3]. The crystallization of urease in 1926 was a significant landmark in biochemistry, showing for the first time ever that enzymes are proteins and can be crystallized [4]. In 1975 it was found that the enzyme contains nickel ions in its active site [5,6]." +"3.5.1.6",The animal enzyme also acts on beta-ureidoisobutyrate. +"3.5.1.9",Also acts on other aromatic formylamines. +"3.5.1.12","The enzyme, found in many bacterial species as well as animals, liberates biotin from biocytin and short biotinylated peptides, but not from biotinylated proteins. It also has activity on biotin esters and biotin amides." +"3.5.1.13",Also acts on 4-substituted anilides. +"3.5.1.14","Contains Zn2+. The enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). It acts on mercapturic acids (S-conjugates of N-acetyl-L-cysteine) and neutral aliphatic N-acyl-alpha-amino acids. Some bacterial aminoacylases demonstrate substrate specificity of both EC 3.5.1.14 and EC 3.5.1.114. cf. EC 3.5.1.15, aspartoacylase and EC 3.5.1.114, N-acyl-aromatic-L-amino acid amidohydrolase." +"3.5.1.16",Also hydrolyses N-acetylmethionine. +"3.5.1.24","Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on choloyl-taurine." +"3.5.1.26","Acts only on asparagine-oligosaccharides containing one amino acid, i.e., the asparagine has free alpha-amino and alpha-carboxyl groups [cf. EC 3.5.1.52, peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase]" +"3.5.1.29",Involved in the degradation of pyridoxin in Pseudomonas. +"3.5.1.30","The enzyme from Pseudomonas putida also acts on 4-aminobutanamide and, more slowly, on 6-aminohexanamide." +"3.5.1.32",Acts on various N-benzoylamino acids. +"3.5.1.36","In the reverse reaction, the product cyclizes non-enzymically to 2-hydroxy-N-methyl-5-oxo-L-proline." +"3.5.1.38","The enzyme from the bacterium Achromobacter hydrolyses L-asparagine at 0.8 of the rate of L-glutamine; the D-isomers are also hydrolysed, but more slowly. cf. EC 3.5.1.2, glutaminase and EC 3.5.1.1, asparaginase." +"3.5.1.39","The enzyme hydrolyses N-monosubstituted and N,N-disubstituted amides, and there is some activity towards primary amides. It has little or no activity towards short-chain substrates." +"3.5.1.40","Also acts on acetylagmatine, propanoylagmatine and bleomycin B2" +"3.5.1.41",Hydrolyses the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin. +"3.5.1.42",Also acts more slowly on beta-nicotinamide D-ribonucleoside. +"3.5.1.43","Specific for the hydrolysis of the gamma-amide of glutamine substituted at the alpha-amino group, e.g., glycyl-L-glutamine, N-acetyl-L-glutamine and L-leucylglycyl-L-glutamine." +"3.5.1.44","Specific for the hydrolysis of the gamma-amide of glutamine substituted at the carboxyl position or both the alpha-amino and carboxyl positions, e.g., L-glutaminylglycine and L-phenylalanyl-L-glutaminylglycine." +"3.5.1.46","The enzyme is involved in degradation of nylon-6 oligomers. It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2--20 by exo-type cleavage, removing residues sequentially from the N-terminus. Activity decreases with the increase of the polymerization number of the oligomer. cf. EC 3.5.1.117, 6-aminohexanoate-oligomer endohydrolase and EC 3.5.2.12, 6-aminohexanoate-cyclic-dimer hydrolase." +"3.5.1.48",It was initially thought that N1-acetylspermidine was the substrate for this deacetylase reaction [1] but this has since been disproved by Marchant et al. [3]. +"3.5.1.49","Also acts, more slowly, on acetamide, propanamide and butanamide." +"3.5.1.50","Also acts, more slowly, on other short-chain aliphatic amides. Different from EC 3.5.1.49 formamidase." +"3.5.1.51",The enzyme also hydrolyses 4-aminobutanoyl-CoA to aminobutanoate and coenzyme A. +"3.5.1.52","Does not act on (GlcNAc)Asn, because it requires the presence of more than two amino-acid residues in the substrate [cf. EC 3.5.1.26, N4-(beta-N-acetylglucosaminyl)-L-asparaginase]. The plant enzyme was previously erroneously listed as EC 3.2.2.18." +"3.5.1.54","Along with EC 3.5.2.15 (cyanuric acid amidohydrolase) and EC 3.5.1.84 (biuret amidohydrolase), this enzyme forms part of the cyanuric-acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine], in bacteria. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 6.3.4.6, urea carboxylase, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate. The enzyme from Pseudomonas sp. strain ADP has a narrow substrate specificity, being unable to use the structurally analogous compounds urea, hydroxyurea or methylcarbamate as substrate [6]." +"3.5.1.55",Does not act on acyl derivates of other amino acids. Optimum chain length of acyl residue is 12 to 16. +"3.5.1.56","An iron protein. Also acts on N-ethylformamide and N-methyl-formamide and, more slowly, on N,N-diethylformamide, N,N-dimethylacetamide and unsubstituted acyl amides." +"3.5.1.57","Requires Mn2+. Also acts on N-ethylformamide and L-tyrosinamide, and on some tryptophan dipeptides." +"3.5.1.58","Also acts, more slowly, on N-benzyloxycarbonylalanine, but not on the corresponding derivatives of other amino acids or on N-benzyloxycarbonylpeptides. Requires Co2+ or Zn2+. cf. EC 3.5.1.64, Nalpha-benzyloxycarbonylleucine hydrolase." +"3.5.1.60","This lysosomal enzyme acts best on palmitoyl ethanolamide, with lower activity on other N-(long-chain-acyl)ethanolamines. It is only active at acidic pH. Unlike EC 3.5.1.99, fatty acid amide hydrolase, it does not act on primary amides such as oleamide, and has only a marginal activity with anandamide. The enzyme is translated as an inactive proenzyme, followed by autocatalytic cleavage into two subunits that reassociate to form an active heterodimeric complex." +"3.5.1.61","An enzyme from Leucaena leucocephala leaf, which also contains the toxic amino acid, mimosine." +"3.5.1.62","The enzyme from Micrococcus luteus also acts on N8-acetylspermidine and acetylcadaverine, but more slowly." +"3.5.1.63",Also acts on N-acetyl-beta-alanine and 5-acetamidopentanoate. +"3.5.1.64","Also acts on Nalpha-t-butoxycarbonyl-L-leucine, and, more slowly, on the corresponding derivatives of L-aspartate, L-methionine, L-glutamate and L-alanine. cf. EC 3.5.1.58 N-benzyloxycarbonylglycine hydrolase." +"3.5.1.65",Also acts on other N-alkyl-L-glutamines. +"3.5.1.66",Involved in the degradation of pyridoxin by Pseudomonas and Arthrobacter. +"3.5.1.68",The animal enzyme also acts on beta-citryl-L-glutamate and beta-citryl-L-glutamine. +"3.5.1.69",Does not act on sphingolipids such as ceramide. Not identical with EC 3.5.1.23 ceramidase. +"3.5.1.71",Hydrolyses a range of L-amino acids from the cinnamoyl and substituted cinnamoyl series. Not identical with EC 3.5.1.14 aminoacylase. +"3.5.1.73",Does not act on D-carnitinamide. +"3.5.1.74","Some other taurine conjugates are hydrolysed, but not glycine conjugates of bile acids." +"3.5.1.76","Identified in Pseudomonas putida. Strict specificity for N-acetyl arylalkylamines, including N-acetyl-2-phenylethylamine, N-acetyl-3-phenylpropylamine, N-acetyldopamine, N-acetyl-serotonin and melatonin. It also accepts arylalkyl acetates but not acetanilide derivatives, which are common substrates of EC 3.5.1.13, aryl acylamidase." +"3.5.1.77","This enzyme, along with EC 3.5.1.87 (N-carbamoyl-L-amino-acid hydrolase), EC 5.1.99.5 (hydantoin racemase) and hydantoinase, forms part of the reaction cascade known as the ""hydantoinase process"", which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids [2]. It has strict stereospecificity for N-carbamoyl-D-amino acids and does not act upon the corresponding L-amino acids or on the N-formyl amino acids, N-carbamoyl-sarcosine, -citrulline, -allantoin and -ureidopropanoate, which are substrates for other amidohydrolases." +"3.5.1.78","Spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule. The enzyme from Escherichia coli is bifunctional and also catalyses the glutathionylspermidine synthase (EC 6.3.1.8) reaction, resulting in a net hydrolysis of ATP." +"3.5.1.79","In the entry, ""phthalyl"" is used to mean ""2-carboxybenzoyl"". The enzyme from Xanthobacter agilis hydrolyses phthalylated amino acids, peptides, beta-lactams, aromatic and aliphatic amines. The substituent on nitrogen may be an alkyl group, but may also be complex, giving an amino acid or peptide derivative. Substitutions on the phthalyl ring include 6-F, 6-NH2, 3-OH, and a nitrogen in the aromatic ring ortho to the carboxy group attached to the amine. No cofactors are required" +"3.5.1.81",The enzyme from Alcaligenes denitrificans subsp. xylosoxydans and Alcaligenes xylosoxydans subsp. xylosoxydans has wide specificity; hydrolyses N-acyl derivative of neutral D-amino acids. Used in separating D- and L-amino acids. Requires zinc. +"3.5.1.82",The enzyme from Alcaligenes xylosoxydans subsp. xylosoxydans and Pseudomonas sp. is specific for N-acyl-D-glutamate. Requires zinc. +"3.5.1.83",The enzyme from Alcaligenes xylosoxydans subsp. xylosoxydans is specific for N-acyl-D-aspartate. Requires zinc. +"3.5.1.84","The enzyme, characterized from the bacterium Rhizobium leguminosarum bv. viciae 3841, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazide herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The substrate, biuret, forms by the spontaneous decarboxylation of 1-carboxybiuret in the absence of EC 3.5.1.131, 1-carboxybiuret hydrolase." +"3.5.1.130","The enzyme participates in an L-lysine biosynthetic pathway in certain species of archaea and bacteria. In some organisms the enzyme also catalyses the activity of EC 3.5.1.132, [amino group carrier protein]-ornithine hydrolase." +"3.5.1.85",Inhibited by phenylmethanesulfonyl fluoride. Some related acetylated compounds are hydrolysed with variable enantiomeric selectivities. +"3.5.1.87","This enzyme, along with EC 3.5.1.77 (N-carbamoyl-D-amino-acid hydrolase), EC 5.1.99.5 (hydantoin racemase) and hydantoinase, forms part of the reaction cascade known as the ""hydantoinase process"", which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids [3]. The enzyme from Alcaligenes xylosoxidans has broad specificity for carbamoyl-L-amino acids, although it is inactive on the carbamoyl derivatives of glutamate, aspartate, arginine, tyrosine or tryptophan. The enzyme from Sinorhizobium meliloti requires a divalent cation for activity and can hydrolyse N-carbamoyl-L-tryptophan as well as N-carbamoyl L-amino acids with aliphatic substituents [2]. The enzyme is inactive on derivatives of D-amino acids. In addition to N-carbamoyl L-amino acids, the enzyme can also hydrolyse formyl and acetyl derivatives to varying degrees [1,2]. " +"3.5.1.88",Requires iron(II). Also requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. Differs in substrate specifity from EC 3.5.1.31 (formylmethionine deformylase). +"3.5.1.89","Involved in the second step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. The enzyme appears to be composed of a single subunit (PIG-L in mammalian cells and GPI12 in yeast). In some species, the long-chain sn-1-acyl group of the phosphatidyl group is replaced by a long-chain alkyl or alk-1-enyl group." +"3.5.1.90","Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB)." +"3.5.1.91","Zinc is a cofactor. While N-benzylformamide is the best substrate, the enzyme from Arthrobacter pascens can also act on the N-substituted formamides N-butylformamide, N-allylformamide, N-[2-(cyclohex-1-enyl)ethyl]formamide and N-(1-phenylethyl)formamide, but much more slowly. Amides of other acids do not act as substrates." +"3.5.1.92","The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant [5]." +"3.5.1.93","Forms 7-aminocephalosporanic acid, a key intermediate in the synthesis of cephem antibiotics. It reacts only weakly with cephalosporin C." +"3.5.2.1","Contains zinc and is specific for barbiturate as substrate [3]. Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.1.95 (N-malonylurea hydrolase). It was previously thought that the end-products of the reaction were malonate and urea but this has since been disproved [2]. May be involved in the regulation of pyrimidine metabolism, along with EC 2.4.2.9, uracil phosphoribosyltransferase." +"3.5.2.2",Also acts on dihydrothymine and hydantoin. +"3.5.2.6","A group of enzymes of varying specificity hydrolysing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. The latter were formerly listed as EC 3.5.2.8, cephalosporinase." +"3.5.2.11",Also hydrolyses L-lysinamide. +"3.5.2.12",The cyclic dimer of 6-aminohexanoate is converted to the linear dimer. +"3.5.2.13","Highly specific; does not hydrolyse other dioxopiperazines, glycylglycine, proteins or barbiturates." +"3.5.2.15","The enzyme catalyses the ring cleavage of cyanuric acid, an intermediate in the degradation of s-triazide herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is highly specific for cyanuric acid. The product was initially thought to be biuret, but was later shown to be 1-carboxybiuret." +"4.1.1.115",This glycyl radical enzyme has been isolate from a number of bacterial species. Skatole contributes to the characteristic smell of animal faeces. +"3.5.2.16","Succinimide and glutarimide, and sulfur-containing cyclic imides, such as rhodanine, can also act as substrates for the enzyme from Blastobacter sp. A17p-4. The reverse, cyclization, reaction is also catalysed, but much more slowly. It has lower activity towards cyclic ureides, which are the substrates of EC 3.5.2.2, dihydropyrimidinase. " +"3.5.2.17",The reaction is the first stage in the conversion of 5-hydroxyisourate into S-allantoin. This reaction will also occur spontaneously but more slowly. +"3.5.3.1",Also hydrolyses alpha-N-substituted L-arginines and canavanine. +"3.5.3.2",Requires Mn2+. +"3.5.3.4",Also hydrolyses (R)-ureidoglycolate to glyoxylate and urea. +"3.5.3.6",Also acts on canavanine. +"3.5.3.7","Requires Mn2+. Also acts, very slowly, on 5-guanidinopentanoate and 6-guanidinohexanoate." +"3.5.3.9","This enzyme is part of the ureide pathway, which permits certain organisms to recycle the nitrogen in purine compounds. This enzyme, which liberates ammonia from allantoate, is present in plants and bacteria. In plants it is localized in the endoplasmic reticulum. Requires manganese." +"3.5.3.12","The plant enzyme also catalyses the reactions of EC 2.1.3.3 (ornithine carbamoyltransferase), EC 2.1.3.6 (putrescine carbamoyltransferase) and EC 2.7.2.2 (carbamate kinase), thus functioning as a putrescine synthase, converting agmatine and ornithine into putrescine and citrulline, respectively." +"3.5.3.14",Also acts slowly on N-amidino-L-glutamate. +"3.5.3.15","Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters." +"3.5.3.16","Acts on some other alkylguanidines, but very slowly." +"3.5.3.17","Requires Mn2+. Also acts, more slowly, on taurocyamine and 4-guanidinobutanoate." +"3.5.3.18",Also acts on Nomega-methyl-L-arginine. +"3.5.3.20","Other diguanidinoalkanes with 3 to 10 methylene groups can also act, but more slowly." +"3.5.3.21","Methylenediurea is hydrolysed and decarboxylated to give an aminated methylurea, which then spontaneously hydrolyses to hydroxymethylurea. The enzyme from Ochrobactrum anthropi also hydrolyses dimethylenetriurea and trimethylenetetraurea as well as ureidoglycolate, which is hydrolysed to urea and glyoxylate, and allantoate, which is hydrolysed to ureidoglycolate, ammonia and carbon dioxide." +"3.5.3.22","Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It carries out an intermediary reaction between the first reaction of EC 1.14.11.21, clavaminate synthase, and the second and third reactions of that enzyme. Requires Mn2+." +"3.5.4.1",Also acts on 5-methylcytosine. +"3.5.4.4","The enzyme, found in a wide variety of microorganisms, plants, invertebrates, and animals, plays a role in purine metabolism." +"3.5.4.5","Contains zinc. Catalyses the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis." +"3.5.4.6",cf. EC 3.5.4.17 adenosine-phosphate deaminase. +"3.5.4.8","Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3]." +"3.5.4.9","In eukaryotes, the enzyme occurs as a trifunctional enzyme that also has methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and formate---tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes, it occurs as a bifunctional enzyme that also has dehydrogenase (EC 1.5.1.5) activity or formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity." +"3.5.4.11","The animal enzyme is specific for pterin, isoxanthopterin and tetrahydropterin." +"3.5.4.12",Also acts on some 5-substituted dCMPs. +"3.5.4.16","The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin-forming)] and EC 4.2.3.12 (6-pyruvoyltetrahydropterin synthase) [3]." +"3.5.4.17","Acts on AMP, ADP, ATP, NAD+ and adenosine, in decreasing order of activity. The bacterial enzyme can also accept the deoxy derivatives. cf. EC 3.5.4.6, AMP deaminase." +"3.5.4.19",The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase). +"3.5.4.23","Catalyses the deamination of the cytosine moiety of the antibiotics blasticidin S, cytomycin and acetylblasticidin S." +"3.5.4.24","Also acts on isosepiapterin, but more slowly." +"3.5.4.25","The enzyme, found in prokaryotes and some eukaryotes, hydrolytically cleaves the C-N bond at positions 8 and 9 of GTP guanine, followed by a subsequent hydrolytic attack at the base, which liberates formate, and cleavage of the alpha-beta phosphodiester bond of the triphosphate to form diphosphate. The enzyme continues with a slow cleavage of the diphosphate to form two phosphate ions. The enzyme requires zinc and magnesium ions for the cleavage reactions at the GTP guanine and triphosphate sites, respectively. It is one of the enzymes required for flavin biosynthesis in many bacterial species, lower eukaryotes, and plants. cf. EC 3.5.4.16, GTP cyclohydrolase I, EC 3.5.4.29, GTP cyclohydrolase IIa, and EC 3.5.4.39, GTP cyclohydrolase IV." +"3.5.4.26",The substrate is the product of EC 3.5.4.25 GTP cyclohydrolase II. +"3.5.4.27",Methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum. +"3.5.4.29","Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N7-methylguanosine 5'-triphosphate or inosine 5'-triphosphate. Xanthosine 5'-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC 3.5.4.25), this enzyme does not release formate, but does hydrolyse the diphosphate from GTP to phosphate." +"3.5.4.30","Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13, dCTP deaminase and EC 3.6.1.23, dUTP diphosphatase), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly." +"3.5.5.1","Acts on a wide range of aromatic nitriles including (indol-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides. cf. EC 4.2.1.84 nitrile hydratase." +"3.5.5.4","L-Asparagine is formed as an intermediate. cf. EC 4.2.1.65, 3-cyanoalanine hydratase and EC 3.5.1.1, asparaginase." +"3.5.5.5","Requires thiol compounds. Also hydrolyses other 4-substituted phenylacetonitriles, thien-2-ylacetonitrile, tolylacetonitriles, and, more slowly, benzyl cyanide." +"3.5.5.6",Involved in the bacterial degradation of the herbicide bromoxynil. Highly specific. +"3.5.5.7","Preferentially hydrolyses aliphatic nitriles, some of which are apparently not substrates for other known nitrilases (EC 3.5.5.1). Substrates include crotononitrile, acrylonitrile and glutaronitrile." +"3.5.5.8",The enzyme from Thiobacillus thioparus catalyses the first step in the degradation of thiocyanate. +"3.5.99.2","Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways." +"3.5.99.3","Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine." +"3.5.99.4","Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopopylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine." +"3.5.99.5","2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions." +"3.5.99.6","The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme." +"3.5.99.7","A pyridoxal 5'-phosphate enzyme. The enzyme, found in certain soil bacteria and fungi, catalyses the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation." +"3.6.1.1","Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC 3.1.3.1 (alkaline phosphatase) or EC 3.1.3.9 (glucose-6-phosphatase). cf. EC 7.1.3.1, H+-exporting diphosphatase." +"3.6.1.3",Many enzymes previously listed under this number are now listed separately under EC 3.6.3 and EC 3.6.4. +"3.6.1.5","Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyse NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. They differ from ATPases, which specifically hydrolyse ATP, by hydrolysing both ATP and ADP. The eukaryotic enzymes requires Ca2+, but Mg2+ can substitute. Most of the ecto-ATPases that occur on the cell surface and hydrolyse extracellular nucleotides belong to this enzyme family." +"3.6.1.6","The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate. Specificity depends on species and isoform." +"3.6.1.8","Also acts on ITP, GTP, CTP and UTP." +"3.6.1.9","The enzyme preferentially hydrolyses ATP, but can also hydrolyse other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD+, NADP+, FAD, and CoA." +"3.6.1.10",The product contains 4 or 5 phosphate residues. +"3.6.1.12","The mammalian enzyme also displays weak activity against dTTP and dATP, but none against dGTP. Activity is highest with analogs including 5-iodo-dCTP and 5-methyl-dCTP." +"3.6.1.14",Also acts on inosine tetraphosphate and tripolyphosphate but shows little or no activity with other nucleotides or polyphosphates. +"3.6.1.15","The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. Also hydrolyses nucleoside diphosphates, thiamine diphosphate and FAD. The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin [5]." +"3.6.1.17","Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC 3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]" +"3.6.1.18",The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC 3.6.1.9 nucleotide diphosphatase. +"3.6.1.19",May be identical with EC 3.6.1.9 nucleotide diphosphatase. +"3.6.1.20",Also acts on inosine and uridine compounds. +"3.6.1.21",Has a specificity that is distinct from that of UDP-sugar diphosphatase (EC 3.6.1.45). +"3.6.1.22","This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. Also acts on other dinucleotides, including NADP(H), FAD(H2), and the thionicotinamide analogues of NAD+ and NADP+." +"3.6.1.23","The enzyme catalyses the Mg2+-dependent hydrolysis of dUTP to dUMP, providing the substrate for EC 2.1.1.45, thymidylate synthase, leading to production of thymidine nucleotides. By reducing the effective ratio of dUTP to TTP, the enzyme also reduces the possibility of dUTP incorporation into DNA." +"3.6.1.24","Attacks ribonucleoside 5'-nitrophenylphosphates, but is inactive against phosphodiesters." +"3.6.1.27","Isolated from the bacteria Micrococcus lysodeikticus [1], Escherichia coli [2,3,5,6] and Bacillus subtilis [4]. The product of the reaction, ditrans,octacis-undecaprenyl phosphate, is essential for cell wall polysaccharide biosynthesis in these strains." +"3.6.1.31",The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase). +"3.6.1.39","Also acts, more slowly, on dUTP and UTP." +"3.6.1.40","Also hydrolyses other guanosine 5'-triphosphate derivatives with at least one unsubstituted phosphate group on the 3'-position, but not GTP, ATP or adenosine 5'-triphosphate 3'-diphosphate." +"3.6.1.41","Also acts on bis(5'-guanosyl) tetraphosphate and bis(5'-adenosyl) pentaphosphate and, more slowly, on some other polyphosphates, forming a nucleoside bisphosphate as one product in all cases [cf. EC 3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)]." +"3.6.1.42",Also acts on UDP but not on other nucleoside diphosphates and triphosphates. +"3.6.1.45","A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5'-nucleotidase (see EC 3.1.3.5) activity." +"3.6.1.52","This enzyme hydrolyses the diphosphate bond, leaving a phospho group where a diphospho group had been. It can also act on bis(adenosine) diphosphate." +"3.6.2.2",Requires Mn2+. +"3.6.3.1","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme moves phospholipids such as phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine from one membrane face to the other ('flippase')." +"3.6.3.2","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in both Gram-positive and Gram-negative bacteria, and three types are known, designated as CorA, MgtA and MgtB. The CorA itself is not an ATPase but an Mg2+ transporter." +"3.6.3.3","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants." +"3.6.3.4","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme from the termophilic bacterium Archaeoglobus fulgidus is involved in copper extrusion from the cell [1,2]." +"3.6.3.5",A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme also exports Cd2+ and Pb2+. +"3.6.3.6","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane." +"3.6.3.7","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed." +"3.6.3.8","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme family comprises three types of Ca2+-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in yeast. The first and third transport one ion per ATP hydrolysed, whereas the second transports two ions. Ca2+ is transported from the cytosol [side 1] into the sarcoplasmic reticulum in muscle cells [side 2]." +"3.6.3.9","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential." +"3.6.3.10",A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed. +"3.6.3.11",A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. An animal and plant enzyme involved in the import of chloride anions. +"3.6.3.12",A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A bacterial enzyme of di(heterotetrameric) structure that is involved in K+ import. The probable stoichiometry is one ion per ATP hydrolysed. +"3.6.3.14","A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. Within this complex, the gamma- and epsilon-subunits, as well as the 9-12 c subunits rotate by consecutive 120_degree_ angles and perform parts of ATP synthesis. This movement is driven by the H+ electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archebacterial) enzymes have a similar structure but, under physiological conditions, they pump H+ rather than synthesize ATP." +"3.6.3.15",A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. An enzyme found in alkaliphilic bacteria that is similar to EC 3.6.3.14 (H+-transporting two-sector ATPase) where Na+ replaces H+. +"3.6.3.16",A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. A bacterial enzyme that usually contains two subunits where one (with 12 membrane-spanning segments) forms the 'channel' part and the other (occurring in pairs peripherally to the membrane) contains the ATP-binding site. Exports arsenite and antimonite anions. +"3.6.3.17","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Family of bacterial enzymes importing ribose, xylose, arabinose, galactose and methylgalactoside." +"3.6.3.18","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports lactose, melibiose and raffinose." +"3.6.3.19","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import maltose and maltose oligosaccharides." +"3.6.3.20","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports phosphorylated glycerol." +"3.6.3.21","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline." +"3.6.3.22","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Comprises bacterial enzymes that import Leu, Ile and Val." +"3.6.3.23","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports di- and oligopeptides." +"3.6.3.24","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Ni2+." +"3.6.3.25","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports sulfate and thiosulfate anions." +"3.6.3.26","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports NO3-, NO2- and OCN-." +"3.6.3.27","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports phosphate anions." +"3.6.3.28","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports phosphonate and organophosphate anions." +"3.6.3.29","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports molybdate anions." +"3.6.3.30","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports ferric cations." +"3.6.3.31","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports putrescine and spermidine." +"3.6.3.32","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports betaine and glycine." +"3.6.3.33","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports cobalamin derivatives." +"3.6.3.34","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores." +"3.6.3.35","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports Mn2+, Zn2+ and iron chelates." +"3.6.3.36","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports taurine." +"3.6.3.37","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A eukaryotic enzyme that imports guanine and tryptophan (it contains a single ATP-binding site)." +"3.6.3.38","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme that exports capsular polysaccharide from Gram-negative bacteria." +"3.6.3.39","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. Enzymes of Gram-negative bacteria that export lipo-oligosaccharides and lipopolysaccharides." +"3.6.3.40","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme found in Gram-positive bacteria that exports teichoic acid." +"3.6.3.41","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme found in Gram-negative bacteria that exports heme." +"3.6.3.42","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme found in Gram-negative bacteria that exports beta-glucan." +"3.6.3.43","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A family of enzymes that exports alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." +"3.6.3.44","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. The enzyme from Gram-positive bacteria and eukaryotic cells export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione---drug conjugates. Some also show some 'flippase' (phospholipid-translocating ATPase; EC 3.6.3.1) activity." +"3.6.3.45","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A yeast protein that exports a variety of xenobiotics, especially steroids." +"3.6.3.46","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports some heavy metals, especially Cd2+, from the cytosol into the vacuole." +"3.6.3.47","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome." +"3.6.3.48","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports the alpha-factor sex pheromone." +"3.6.3.49","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels." +"3.6.3.50","A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. There are several families of enzymes included here, e.g. ATP-hydrolysing enzymes of the general secretory pathway (Sec or Type II), of the virulence-related secretory pathway (Type III) and of the conjugal DNA-protein transfer pathway (Type IV). Type II enzymes occur in bacteria, archaea and eucarya, whereas type III and type IV enzymes occur in bacteria where they form components of a multi-subunit complex." +"3.6.3.51","A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. (TIM is the protein transport machinery of the inner mitochondrial membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.)" +"3.6.3.52","A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. Involved in the transport of proteins or preproteins into chloroplast stroma (several ATPases may participate in this process)." +"3.6.3.53",A P-type ATPase that exports Ag+ ions from pathogenic microorganisms as well as from some animal tissues. +"3.6.4.1",Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15-27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction. +"3.6.4.2","A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa)." +"3.6.4.3","Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome." +"3.6.4.4","Microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (alpha) chains (110 kDa) and two or more light (beta) chains (65-75 kDa). Also hydrolyses GTP." +"3.6.4.5",Structurally almost identical to EC 3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules. +"3.6.4.6","A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (_A_TPase _a_ssociated with a variety of cell _a_ctivities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome." +"3.6.4.7",An extremely diversified group of enzymes that use the energy of ATP hydrolysis to import and assemble peroxisome components into the organelle. Their molecular masses range from 25 to 600 kDa. +"3.6.4.8","Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." +"3.6.4.9","Multisubunit proteins with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or entry into mitochondria and chloroplasts. Molecular masses of subunits ranges from 10-90 kDa. They are a subclass of molecular chaperones that are related to EC 3.6.4.8 (proteasome ATPase)." +"3.6.4.10",This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin. +"3.6.4.11","An acidic nuclear protein that is active in the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." +"3.6.5.1","This group comprises GTP-hydrolysing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. Golf is instrumental in odour perception, transducin in vision and gustducin in taste recognition. At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known." +"3.6.5.2","A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase (EC 3.6.5.1). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." +"3.6.5.3","This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolysing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1alpha (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF-1alpha catalyse binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyse the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." +"3.6.5.4",Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis). +"3.6.5.5",An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles. +"3.6.5.6","An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." +"3.7.1.2","Also acts on other 3,5- and 2,4-dioxo acids." +"3.7.1.3",A pyridoxal-phosphate protein. Also acts on 3'-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines. +"3.7.1.4",Also hydrolyses other C-acylated phenols related to phloretin. Isolated from the fungus Aspergillus niger and the bacteria Pantoea agglomerans and Eubacterium ramulus. +"3.7.1.5","Acts on formylpyruvate, 2,4-dioxopentanoate, 2,4-dioxohexanoate and 2,4-dioxoheptanoate." +"3.7.1.6","Highly specific; does not act on pyruvate, oxaloacetate, maleylpyruvate, fumarylpyruvate or acetylacetone." +"3.7.1.7","Also acts on the product of the action of EC 1.1.3.18 secondary-alcohol oxidase, on polyvinyl alcohols; involved in the bacterial degradation of polyvinyl alcohol." +"3.7.1.8","Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp." +"3.7.1.9",The enzyme is involved in the degradation of catechols. +"3.7.1.10","Highly specific; does not act on other dione derivatives of cyclohexane, cyclopentane or cycloheptane." +"3.8.1.2","Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC 3.8.1.9 (R)-2-haloacid dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]" +"3.8.1.5","Acts on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds." +"3.8.1.6","Catalyses the first step in the degradation of chlorobenzoate in Pseudomonas. In many microorganisms, this activity comprises three separate enzymes, EC 6.2.1.33 (4-chlorobenzoate---CoA ligase), EC 3.8.1.7 (4-chlorobenzoyl-CoA dehalogenase) and EC 3.1.2.23 (4-hydroxybenzoyl-CoA thioesterase)." +"3.8.1.7","Specific for dehalogenation at the 4-position. Can dehalogenate substrates bearing fluorine, chlorine, bromine and iodine in the 4-position. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway." +"3.8.1.8","Involved in the degradation of the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, in bacteria." +"3.8.1.9","Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]" +"3.8.1.10","Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]" +"3.8.1.11","Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)]" +"3.9.1.1",Also acts on N-phospho-arginine and other phosphoamides. Possibly identical with EC 3.1.3.9 (glucose-6-phosphatase) or EC 3.1.3.16 (protein-serine/threonine phosphatase). +"3.10.1.2",Also readily hydrolyses aliphatic sulfamates with 3 to 8 carbons. +"3.11.1.1","This enzyme destabilizes the C-P bond, by forming an imine between one of its lysine residues and the carbonyl group of the substrate, thus allowing this, normally stable, bond to be broken. The mechanism is similar to that used by EC 4.1.2.13, fructose-bisphosphate aldolase, to break a C-C bond. Belongs to the haloacetate dehalogenase family." +"3.11.1.2",A zinc-dependent enzyme. Belongs to the alkaline phosphatase superfamily of zinc-dependent hydrolases. +"3.13.1.1","Requires NAD+, which appears to oxidize UDP-alpha-D-glucose to UDP-4-dehydroglucose, which dehydrates to UDP-4-dehydro-6-deoxygluc-5-enose, to which sulfite is added. The reaction is completed when the substrate is rehydrogenated at C-4. The enzyme from Arabidopsis thaliana is specific for UDP-Glc and sulfite." +"3.13.1.3",The enzyme from Rhodococcus sp. strain IGTS8 is encoded by the plasmid-encoded dibenzothiophene-desulfurization (dsz) operon. The enzyme has a narrow substrate specificity with biphenyl-2-sulfinate being the only other substrate known to date [2]. +"3.4.11.1",A zinc enzyme isolated from pig kidney and cattle lens; activated by heavy metal ions. Type example of peptidase family M17. +"3.4.11.2","A zinc enzyme, not activated by heavy metal ions. Type example of peptidase family M1." +"3.4.11.3",A zinc-containing sialoglycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family) +"3.4.11.4","A zinc enzyme, widely distributed in mammalian tissues. Formerly EC 3.4.1.3" +"3.4.11.5","A Mn2+-requiring enzyme present in the cytosol of mammalian and microbial cells. In contrast to the mammalian form, the bacterial form of the enzyme (type example of peptidase family S33) hydrolyses both polyproline and prolyl-2-naphthylamide. The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1, leucyl aminopeptidase." +"3.4.11.6","Cytosolic or membrane-associated enzyme from mammalian tissues, activated by chloride ions and low concentrations of thiol compounds. This is one of the activities of the bifunctional enzyme EC 3.3.2.6 (membrane alanyl aminopeptidase family) [4,5]." +"3.4.11.7",Ca2+-activated and generally membrane-bound. A zinc-metallopeptidase in family M1 (membrane alanyl aminopeptidase family) +"3.4.11.9","A Mn2+-dependent, generally membrane-bound enzyme present in both mammalian and bacterial cells. In peptidase family M24 (methionyl aminopeptidase family)" +"3.4.11.10","A zinc enzyme. Forms of the enzyme have been isolated from Aeromonas proteolytica, Escherichia coli and Streptococcus thermophilus. Examples are known from peptidase families M17 and M28 (of leucyl aminopeptidase and aminopeptidase Y, respectively)" +"3.4.11.13","A secreted enzyme from Clostridium histolyticum, requiring Mn2+ or Co2+. In peptidase family M9." +"3.4.11.14","A puromycin-sensitive, Co2+-activated zinc-sialoglycoprotein that is generally cytosolic. Multiple forms are widely distributed in mammalian tissues and body fluids. In peptidase family M1 (membrane alanyl aminopeptidase family)" +"3.4.11.15","Requires Co2+; inhibited by Zn2+ and Mn2+. An enzyme best known from Saccharomyces cerevisiae that hydrolyses Lys-NHPhNO2 and, more slowly, Arg-NHPhNO2. Type example of peptidase family M28" +"3.4.11.16","A glycoprotein containing Zn2+, from renal and intestinal brush border membranes. In peptidase family M9." +"3.4.11.17",From Trichosporon cutaneum. Also acts on L-tryptophanamide. Requires Mn2+ +"3.4.11.18","This membrane-bound enzyme, which is present in both prokaryotes and eukaryotes, releases the initiator methionine from nascent peptides. The activity is dependent on the identity of the second, third and fourth amino acid residues of the target protein, but in general the enzyme acts only when the penultimate residue is small and uncharged (e.g. Gly, Ala, Cys, Ser, Thr, and Val). In peptidase family M24." +"3.4.11.19",Known from the bacterium Ochrobactrum anthropi. In peptidase family S12 (D-Ala-D-Ala carboxypeptidase family) [2] +"3.4.11.20","A zinc glycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family), composed of two 150 kDa subunits. From the plasma fraction of hen egg yolk" +"3.4.11.21","Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, in peptidase family M18 of aminopeptidase I" +"3.4.11.22","A 640-kDa, dodecameric enzyme best known as the major vacuolar aminopeptidase of yeast, Saccharomyces cervisiae, in which species it was first given the name aminopeptidase I (one), amongst others. Activity is stimulated by both Zn2+ and Cl- ions. Type example of peptidase family M18" +"3.4.11.23",A 270-kDa protein composed of six 46.3-kDa subunits. The pH optimum is in the alkaline range and activity is stimulated by KCl. In peptidase family M17. +"3.4.13.3","A mammalian cytosolic enzyme that also acts on anserine and homocarnosine (but not on homoanserine), and to a lesser extent on some other aminoacyl-L-histidine dipeptides. Activated by thiols; inhibited by metal-chelating agents. This enzyme in peptidase family M25 may be identical with EC 3.4.13.18, cytosol nonspecific dipeptidase." +"3.4.13.4",Widely distributed in mammals +"3.4.13.7",It is unclear whether the specificity of this enzyme extends to other alpha-glutamyl dipeptides +"3.4.13.9","A Mn2+-activated enzyme, in peptidase family M24 (methionyl aminopeptidase family); cytosolic from most animal tissues." +"3.4.13.12",A Mn2+-activated Escherichia coli enzyme with thiol dependence +"3.4.13.17",A digestive enzyme of cephalopods +"3.4.13.18","A zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine." +"3.4.13.19","A membrane-bound, zinc enzyme with broad specificity. Abundant in the kidney cortex. Inhibited by bestatin and cilastatin. Type example of peptidase family M19." +"3.4.13.20","Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs in peptidase family M20." +"3.4.13.21","A free carboxy group is not absolutely required in the substrate since Asp-Phe-NH2 and Asp-Phe-OMe are hydrolysed somewhat more slowly than dipeptides with free C-termini. No peptide larger than a C-blocked dipeptide is known to be a substrate. Asp-NH-Np is hydrolysed and is a convenient substrate for routine assay. The enzyme is most active near pH 7.0, and is not inhibited by di-isopropylfluorophosphate or phenylmethanesulfonyl fluoride. Belongs in peptidase family S51." +"3.4.14.1","A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family)." +"3.4.14.2",A lysosomal serine-type peptidase in family S28 (Pro-X carboxypeptidase family); maximally active at acidic pH +"3.4.14.4","A cytosolic peptidase that is active at neutral pH. It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2. Active in the hydrolysis of enkephalins. A metallopeptidase, the type example of peptidase family M49." +"3.4.14.5","A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated EC 3.4.14.11 Xaa-Pro dipeptidyl-peptidase of lactococci" +"3.4.14.6","A thiol-activated peptidase from cabbage (Brassica oleracea). Tetrapeptides are formed from Ala-Ala, Gly-Gly, Ala-Gly and Gly-Ala" +"3.4.14.9",A lysosomal enzyme that is active at acidic pH. Deficient in classical late-infantile neuronal ceroid lipofuscinosis brain tissue. Belongs in peptidase family S53. Formerly included in EC 3.4.14.8. +"3.4.14.10",A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8 +"3.4.14.11",The intracellular enzyme from Lactococcus lactis (190-kDa) is the type example of peptidase family S15. The reaction is similar to that catalysed by dipeptidyl-peptidase IV of animals +"3.4.15.1","A Cl--dependent, zinc glycoprotein that is generally membrane-bound. A potent inhibitor is captopril. Important in elevation of blood pressure, through formation of angiotensin II (vasoconstrictor) and destruction of bradykinin (vasodilator). Two molecular forms exist in mammalian tissues, a widely-distributed somatic form of 150- to 180-kDa that contains two non-identical catalytic sites, and a testicular form of 90- to 100-kDa that contains only a single catalytic site. Type example of peptidase family M2" +"3.4.15.4","A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it displays no Cl- dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II" +"3.4.15.5","Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase in peptidase family M3 (thimet oligopeptidase family). Ac-Ala!Ala-Ala is a good test substrate [3]. Inhibited by captopril, as is peptidyl-dipeptidase A. Formerly EC 3.4.15.3, and included in EC 3.4.15.1, peptidyl-dipeptidase A." +"3.4.16.2",A lysosomal peptidase active at acidic pH that inactivates angiotensin II. Inhibited by diisopropyl fluorophosphate. In peptidase family S28 (Pro-X carboxypeptidase family). +"3.4.16.4","A membrane-bound, bacterial enzyme inhibited by penicillin and other beta-lactam antibiotics, which acylate the active site serine. Examples are known from peptidase families S11, S12 and S13. Distinct from EC 3.4.17.14, zinc D-Ala-D-Ala carboxypeptidase" +"3.4.16.5","A carboxypeptidase with optimum pH 4.5--6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10." +"3.4.16.6","A carboxypeptidase with optimum pH 4.5-6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). In peptidase family S10 (carboxypeptidase C family)." +"3.4.17.1","A zinc enzyme formed from procarboxypeptidase A. Isolated from cattle, pig and dogfish pancreas, and other sources including mast cells [3] and skeletal muscle [4]. Type example of peptidase family M14." +"3.4.17.2","A zinc enzyme formed from procarboxypeptidase B. Isolated from cattle, pig and dogfish pancreas and other sources, including skin fibroblasts [3] and adrenal medulla [4]. In peptidase family M14 (carboxypeptidase A family)." +"3.4.17.3",A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family). +"3.4.17.4",From yeast. In peptidase family M20 (glutamate carboxypeptidase family). +"3.4.17.6",From soil bacteria. The enzyme from Corynebacterium equi also hydrolyses N-benzoylglycine and N-benzoyl-L-aminobutyric acid. +"3.4.17.8","A bacterial enzyme that requires a divalent cation for activity. Does not cleave the C-terminal D-alanine from the product of the above reaction, UDP-N-acetyl-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine. Competitively inhibited by penicillins and cephalosporins." +"3.4.17.10","A zinc enzyme, activated by Co2+. Inhibited by 1,10-phenanthroline and other chelating agents. pH optimum 5.6. Located in storage granules of secretory cells, and active in processing of protein hormones and bioactive peptides. In peptidase family M14 (carboxypeptidase A family)." +"3.4.17.11","A zinc enzyme produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp. Its ability to hydrolyse pteroyl-L-glutamate (folic acid) has led to its use as a folate-depleting, antitumour agent. Type example of peptidase family M20" +"3.4.17.12",A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family) +"3.4.17.13","Variants are known from various microorganisms. Involved in peptidoglycan synthesis, catalysing both decarboxylation and transpeptidation. Stimulated by divalent cations such as Mg2+ and Ca2+, but not by Zn2+. Inhibited by thiol-blocking reagents, but unaffected by penicillin" +"3.4.17.14","A zinc enzyme. Catalyses carboxypeptidation but not transpeptidation reactions involved in bacterial cell wall metabolism. Weakly inhibited by beta-lactams. In peptidase family M15. Distinct from EC 3.4.16.4, serine-type D-Ala-D-Ala carboxypeptidase." +"3.4.17.15",Isolated from rat pancreas but not present in cattle pancreas. In peptidase family M14 (carboxypeptidase A family). +"3.4.17.16",One of the renal brush border exopeptidases +"3.4.17.17","Active at neutral pH, from brain" +"3.4.17.18",Known from Thermoactinomyces vulgaris. In peptidase family M14 (carboxypeptidase A family) +"3.4.17.19",A 56-kDa enzyme from Thermus aquaticus. Most active at 80_degree_ C. Type example of peptidase family M32 +"3.4.17.20","Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U, with activity similar to that of the more stable lysine carboxypeptidase, except that no preference is shown for Lys over Arg. A zinc enzyme, in peptidase family M14 (carboxypeptidase A family)" +"3.4.17.21","A metallo-carboxypeptidase that is predominantly expressed as a membrane-bound enzyme of 94-100 kDa , but also exists in a soluble form. Hydrolyses alpha-peptide bonds in Ac-Asp-Glu, Asp-Glu, and Glu-Glu, but also gamma-glutamyl bonds in gamma-Glu-Glu, and folylpoly-gamma-glutamates. With folylpoly-gamma-glutamates, shows processive carboxypeptidase activity to produce pteroylmonoglutamate [4]. Does not hydrolyse Ac-beta-Asp-Glu. Known inhibitors: quisqualic acid, Ac-beta-Asp-Glu, and 2-phosphonomethyl-pentanedioate. In peptidase family M28 of Vibrio leucyl aminopeptidase. The release of C-terminal glutamate from folylpoly-gamma-glutamates is also catalysed by EC 3.4.17.11 (glutamate carboxypeptidase) and EC 3.4.19.9 (folate gamma-glutamyl hydrolase)." +"3.4.17.22",Activated by Co2+; inhibited by [(2-guanidinoethyl)sulfanyl]butanedioate. Large molecule (180 kDa) because of presence of three copies of metallopeptidase domain. The product of the silver gene (Drosophila) is similar. A zinc metallopeptidase in peptidase family M14 (carboxypeptidase A family) +"3.4.18.1","Cathepsin X is a lysosomal cysteine peptidase of family C1 (papain family). The pH optimum is dependent on the substrate and is 5.0 for the carboxypeptidase activity. Unstable above pH 7.0. Compound E-64, leupeptin and antipain are inhibitors, but not cystatin C. Cathepsin X is ubiquitously distributed in mammalian tissues. The propeptide is extremely short (38 amino acid residues) and the proenzyme is catalytically active. Human gene locus: 20q13." +"3.4.19.1","This is a bifunctional serine protease that has exopeptidase activity against Nalpha-acylated peptides and endopeptidase activity against oxidized and glycated proteins. In its exopeptidase mode the enzyme cleaves an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. This class of enzymes is evolutionary deeply conserved and is found in bacteria, archaea, animals and plants with different quartenary structures. In humans, malfunction is linked to different types of cancer and sarcoma cell viability. In peptidase family S9 (prolyl oligopeptidase family)." +"3.4.19.2","Inactivates vasopressin and oxytocin by splitting off glycinamide. Also cleaves ester substrates of trypsin and chymotrypsin. Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide. The toad skin enzyme is inhibited by diisopropyl fluorophosphate." +"3.4.19.3","A cysteine peptidase, known from bacteria, plants and animals. The enzyme from bacterial sources is used in protein sequencing, and is the type example of peptidase family C15." +"3.4.19.5","Other isopeptide bonds, e.g. gamma-glutamyl and beta-alanyl, are not hydrolysed. A mammalian, cytosolic enzyme." +"3.4.19.6",Highly specific for thyrotropin releasing hormone (pyroglutamyl-histidyl-prolylamide). Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone. Found in serum and brain. Inhibited by metal chelators. In peptidase family M1 (membrane alanyl aminopeptidase family) +"3.4.19.7",Highly specific for N-formylmethionyl peptides. Will not cleave methionyl peptides or N-formyl derivatives of amino acids other than methionine. Isolated from rat liver. Inhibited by heavy metals and activated by Cl- +"3.4.19.9","The enzyme, which occurs only in animals and plants, can be either endo- and/or exopeptidase. It acts on tetrahydropteroyl polyglutamates and their modified forms, as well as the polyglutamates of the folate breakdown product N-(4-aminobenzoyl)-L-glutamate (pABA-Glu). The initial cleavage may release either monoglutamate or poly-gamma-glutamate of two or more residues, depending on the specific enzyme. For example, GGH1 from the plant Arabidopsis thaliana cleaves pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from the same organism yields mainly monoglutamates. The enzyme is lysosomal (and secreted) in animals and vacuolar in plants. In peptidase family C26." +"3.4.19.11","A 45-kDa metallopeptidase from Bacillus sphaericus, the substrates being components of the bacterial spore wall. A member of peptidase family M14 (carboxypeptidase A family). Endopeptidase II has similar activity, but differs in cellular location, molecular mass and catalytic mechanism [3]" +"3.4.19.12","Links to polypeptides smaller than 60 residues are hydrolysed more readily than those to larger polypeptides. Isoforms exist with quantitatively different specificities, amongst the best known being UCH-L1 and UCH-L3, which are major proteins of the brain of mammals [1]. Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). Ubiquitinyl hydrolase 1 is the type example of peptidase family C12, with a similar protein fold to papain and catalytic amino acids Cys, His and Asp. There is a separate family (C19) of enzymes that also hydrolyse ubiquitinyl bonds, and it is thought that all the ubiquitinyl hydrolases are also ubiquitin thiolesterases (EC 3.1.2.15)" +"3.4.21.1","Chymotrypsin A is formed from cattle and pig chymotrypsinogen A, several iso-forms being produced according to the number of bonds hydrolysed in the precursor. Chymotrypsin B (formerly listed as EC 3.4.4.6), formed from chymotrypsinogen B, is homologous with chymotrypsin A. Enzymes with specificity similar to that of chymotrypsins A and B have been isolated from many species. In peptidase family S1 (trypsin family)" +"3.4.21.2","Formed from pig chymotrypsinogen C, and from cattle subunit II of procarboxypeptidase A. Reacts more readily with Tos-Leu-CH2Cl than Tos-Phe-CH2Cl in contrast to chymotrypsin. In peptidase family S1 (trypsin family)" +"3.4.21.3",Digestive enzyme from the sea anemone Metridium senile. +"3.4.21.4","The single polypeptide chain cattle beta-trypsin is formed from trypsinogen by cleavage of one peptide bond. Further peptide bond cleavages produce alpha and other iso-forms. Isolated as multiple cationic and anionic trypsins [5] from the pancreas of many vertebrates and from lower species including crayfish, insects (cocoonase) and microorganisms (Streptomyces griseus) [3]. Type example of peptidase family S1." +"3.4.21.5",Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family). +"3.4.21.6","A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va." +"3.4.21.7",Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. In peptidase family S1 (trypsin family). +"3.4.21.9",Is not inhibited by protein inhibitors of trypsin. In peptidase family S1 (trypsin family). +"3.4.21.10",Occurs in spermatozoa; formed from proacrosin by limited proteolysis. Inhibited by naturally occurring trypsin inhibitors. In peptidase family S1 (trypsin family) +"3.4.21.12",From the myxobacterium Lysobacter enzymogenes. In peptidase family S1 (trypsin family) +"3.4.21.19",From Staphylococcus aureus strain V8. In appropriate buffer the specificity is restricted to Glu!. In peptidase family S1 (trypsin family) +"3.4.21.20",From azurophil granules of polymorphonuclear leukocytes. In peptidase family S1 (trypsin family) +"3.4.21.21",Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human [1]. In peptidase family S1 (trypsin family) +"3.4.21.22","A chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family)" +"3.4.21.25","From the sarcocarp of the musk melon (Cucumis melo). In peptidase family S8 (subtilisin family). Other endopeptidases from plants, which are less well characterized but presumably of serine-type, include euphorbain from Euphorbia cerifera [6], solanain from horse-nettle Solanum elaeagnifolium [1], hurain from Hura crepitans [2] and tabernamontanain from Tabernamontana grandiflora [3]." +"3.4.21.26","Found in vertebrates, plants and Flavobacterium. Generally cytosolic, commonly activated by thiol compounds. Type example of peptidase family S9." +"3.4.21.27","In peptidase family S1 (trypsin family), and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa" +"3.4.21.32","From hepatopancreas of the fiddler crab, Uca pugilator. In peptidase family S1 (trypsin family). Other serine endopeptidases that degrade collagen, but are not listed separately here, include a second endopeptidase from Uca pugilator [4], digestive enzymes from other decapod crustacea [5,6], and an enzyme from the fungus Entomophthora coronata [1]." +"3.4.21.34","Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates." +"3.4.21.35","Formed from tissue prokallikrein by activation with trypsin. In peptidase family S1 (trypsin family). A large number of tissue kallikrein-related sequences have been reported for rats [16] and mice [7], though fewer seem to exist in other mammals. The few that have been isolated and tested on substrates include mouse gamma-renin (EC 3.4.21.54), submandibular proteinase A [2,15], epidermal growth-factor-binding protein, nerve growth factor gamma-subunit, rat tonin [3,4,9], submaxillary proteinases A and B [10], T-kininogenase [18], kallikreins k7 and k8 [17] and human prostate-specific antigen (gamma-seminoprotein, [6])" +"3.4.21.36",Formed by activation of proelastase from mammalian pancreas by trypsin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11 +"3.4.21.37",Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11 +"3.4.21.38","Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family)" +"3.4.21.39",In mast cell granules. In peptidase family S1 (trypsin family) +"3.4.21.41","Activated from proenzyme C_overbar_1r_ in plasma during activation of the complement system by the ""classical"" route. In peptidase family S1 (trypsin family)" +"3.4.21.42",Activated from proenzyme C1s in plasma by complement subcomponent C_overbar_1r_. In peptidase family S1 (trypsin family) +"3.4.21.43","A complex of complement fragments C4b, C2a and C2b. C2a contains the active site, C2b the site for C4b binding. C2a and C2b are formed by cleavage of proenzyme C2 by complement subcomponent C_overbar_1s_. Cleavage of C5 requires complement fragment C3b which binds C5 and renders it susceptible to cleavage by the C4b,2a complex. Includes former EC 3.4.21.44. Complement component C2a is in peptidase family S1 (trypsin family)" +"3.4.21.45",Cleavage of complement subcomponent C3b requires its binding to cofactor factor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. In peptidase family S1 (trypsin family) +"3.4.21.46",A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C_overbar_1s_. In peptidase family S1 (trypsin family) +"3.4.21.47","A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. Bb is formed by cleavage of proenzyme factor B by factor D. Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. C3b,Bb is stabilized in plasma by factor P. Complement factor B is in peptidase family S1 (trypsin family)" +"3.4.21.48","From Saccharomyces cerevisiae (baker's yeast, brewer's yeast). In peptidase family S8 (subtilisin family), but contains a Cys residue near the active site His, and is inhibited by mercurials. Proteinase ycaB is a similar enzyme from the yeast Candida albicans [3]" +"3.4.21.49","From the larva of a warble fly, Hypoderma lineatum. Little action on small molecule substrates of trypsin, chymotrypsin, elastase or microbial collagenases. In peptidase family S1 (trypsin family)" +"3.4.21.50",From Achromobacter lyticus [6]. Enzymes with similar specificity are produced by Lysobacter enzymogenes (Endoproteinase Lys-C; [3]) and Pseudomonas aeruginosa (Ps-1; [4]). In peptidase family S1 (trypsin family) +"3.4.21.53",Product of the lon gene in Escherichia coli. ATP hydrolysis is linked with peptide bond hydrolysis; vanadate inhibits both reactions. Type example of peptidase family S16. A similar enzyme occurs in animal mitochondria +"3.4.21.54","A member of the tissue kallikrein family, from submandibular glands of male mice. In peptidase family S1 (trypsin family)" +"3.4.21.55","From the venom of the Gaboon viper Bitis gabonica. Activates Factor XIII. Not inhibited by antithrombin III/heparin or hirudin, unlike EC 3.4.21.5, thrombin" +"3.4.21.57",From leaves of the spinach plant (Spinacia oleracea) +"3.4.21.59","Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. In peptidase family S1 (trypsin family). Not inhibited by alpha1-proteinase inhibitor or alpha2-macroglobulin" +"3.4.21.60","From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca2+ which binds via gamma-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis. A member of peptidase family S1." +"3.4.21.61","A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals." +"3.4.21.62","Subtilisin is a serine endopeptidase, type example of peptidase family S8. It contains no cysteine residues (although these are found in homologous enzymes). Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase B, subtilopeptidase C, Nagarse, Nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo). Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species [1,3]" +"3.4.21.63","A peptidase of family S8 (subtilisin family), not containing cysteine, that is the predominant extracellular alkaline endopeptidase of the mold Aspergillus oryzae. Identical or closely related enzymes are produced by A. flavus and A. sojae [2,3,4]" +"3.4.21.64",From the mold Tritirachium album Limber. A peptidase of family S8 (subtilisin family) containing two disulfide bridges and one free Cys near the active site His. Formerly included in EC 3.4.21.14 +"3.4.21.65","A peptidase of family S8 (subtilisin family) from the thermophilic fungus Malbranchea pulchella var. sulfurea containing Cys, but not inhibited by p-mercuribenzoate. Very thermostable. Formerly included in EC 3.4.21.14" +"3.4.21.66","A peptidase of family S8 (subtilisin family) from Thermoactinomyces vulgaris containing a single Cys, near the active site His, and inhibited by p-mercuribenzoate. The N-terminal extension of the polypeptide chain relative to subtilisin contributes to Ca2+-binding and the high thermostability. The amino acid composition and properties of the thermostable enzyme from Streptomyces rectus var. proteolyticus (formerly included in EC 3.4.21.14) are closely similar [1,2]." +"3.4.21.67","An Escherichia coli cytoplasmic endopeptidase formerly included in EC 3.4.21.14. Inhibited by Tos-Phe-CH2Cl, but not by Tos-Lys-CH2Cl" +"3.4.21.68","A peptidase of family S1 (trypsin family) from a wide variety of mammalian tissues, especially endothelial cells. Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Activity is considerably enhanced by fibrin. Formerly included in EC 3.4.21.31 and EC 3.4.99.26" +"3.4.21.69","A peptidase of family S1 (trypsin family), one of the gamma-carboxyglutamic acid-containing coagulation factors. The enzyme plays an important role in regulating anticoagulation, inflammation, and cell death by proteolytically inactivating the blood coagulation factors factor Va and factor VIIIa. Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin. Protein C can also be activated by serine endopeptidases present in several snake venoms." +"3.4.21.70","A peptidase of family S1 (trypsin family) from pancreatic juice. Unlike elastases, has an acidic pI. Binds cholesterol" +"3.4.21.71","A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species; human pancreatic elastase is of type II" +"3.4.21.72","Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase)" +"3.4.21.73","Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26" +"3.4.21.74","A somewhat thrombin-like enzyme from venoms of snakes of the viper/rattlesnake group. Species variants of the enzyme include ancrod from Agkistrodon rhodostoma (Malayan pit viper) (formerly EC 3.4.21.28) [1], batroxobin from Bothrops atrox (South American pit viper) (formerly EC 3.4.21.29) [2,5] and crotalase from Crotalus adamanteus (Eastern diamondback rattlesnake) (formerly EC 3.4.21.30) [3,4]. In peptidase family S1 (trypsin family). Does not require activation by Ca2+." +"3.4.21.75","One of a group of peptidases in peptidase family S8 (subtilisin family) that is structurally and functionally similar to kexin. All are activated by Ca2+, contain Cys near the active site His, and are inhibited by p-mercuribenzoate. At least three related enzymes are recognized in mammals: PC2, PC3 and PC4, which have somewhat different specificities" +"3.4.21.76",From polymorphonuclear leukocyte granules. In peptidase family S1 (trypsin family). Not inhibited by secretory leukocyte proteinase inhibitor +"3.4.21.77",A peptidase of family S1 (trypsin family) from seminal plasma. Slowly inhibited by alpha1-antichymotrypsin +"3.4.21.78",From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe!- +"3.4.21.79",From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family) +"3.4.21.80","From Streptomyces griseus. A component of Pronase, in family S1 (trypsin family). Not inhibited by Tos-Phe-CH2Cl or ovomucoid" +"3.4.21.81","From Streptomyces griseus. A component of Pronase, in peptidase family S1 (trypsin family), distinct from Streptomyces trypsin" +"3.4.21.82",From Streptomyces griseus. A peptidase of family S1 (trypsin family). Inhibited by [Leu18->Glu]-modified turkey ovomucoid third domain +"3.4.21.83",Known from Escherichia coli. Inhibited by Tos-Lys-CH2Cl. In peptidase family S9 (prolyl oligopeptidase family) +"3.4.21.84",From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. Factor C is activated by Gram-negative bacterial lipopolysaccharides and chymotrypsin. Inhibited by antithrombin III. In peptidase family S1 (trypsin family) +"3.4.21.85",From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. Factor B is activated by limulus clotting factor _overbar_C_. In peptidase family S1 (trypsin family) +"3.4.21.86",From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family) +"3.4.21.87","A product of the ompT gene of Escherichia coli, and associated with the outer membrane. Type example of peptidase family A26" +"3.4.21.88","RecA protein and single-stranded DNA are required for activity, which is attributed to a Ser/Lys dyad [2]. The LexA protein represses the SOS regulon, which regulates the genes involved in DNA repair. In the presence of single-stranded DNA, the RecA protein interacts with repressor LexA, causing it to undergo an autocatalytic cleavage which disrupts the DNA-binding part of the repressor, and inactivates it. The consequent derepression of the SOS regulon leads to DNA repair. This peptidase activity of LexA was previously attributed to the RecA protein. Type example of peptidase family S24" +"3.4.21.89","The enzyme is found in bacterial membranes and in chloroplast thylakoid membranes. Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity [1,3]. Hydrolyses a single bond -Ala!Ala- in M13 phage procoat protein, producing free signal peptide and coat protein. Formerly included in EC 3.4.99.36. Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane [4] and mitochondrial inner membrane [2]. Type example of peptidase family S26" +"3.4.21.90","Known from the Sindbis and Semliki forest togaviruses. Once released, the core protein does not retain catalytic activity. Togavirin is the type example of peptidase family S3 and has a similar tertiary structure to chymotrypsin [3]" +"3.4.21.91","Known from classical flaviviruses (yellow fever, dengue fever). The functional viral peptidase is part of the NS2B protein. Catalytic His, Asp and Ser residues are arranged as in chymotrypsin, but flavivrin is the type example of peptidase family S7." +"3.4.21.92","An enzyme from bacteria that contains subunits of two types, ClpP, with peptidase activity, and ClpA, with ATPase activity. The ClpAP complex, which displays ATP-dependent endopeptidase activity, has the composition (ClpP14ClpA6)2 [4]. ClpP is the type example of peptidase family S14" +"3.4.21.93","A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family)" +"3.4.21.94","A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family)" +"3.4.21.95","Known from venom of Vipera russelli. Inhibited by di-isopropyl fluorophosphate, unlike the metallopeptidase russellysin (EC 3.4.24.58) that is specific for factor X [1]. In peptidase family S1 (trypsin family) [2]." +"3.4.21.96","Associated with the cell envelope of Lactococcus lactis and attached via a C-terminal membrane anchor sequence. Responsible for the hydrolysis of casein in milk and the provision of peptides essential to cell growth. Important in cheese making and the production of lactic casein, being required for rapid growth to high cell densities with concomitant production of adequate levels of lactic acid. Specificity differences between lactocepins from different starter strains may be partly responsible for imparting different flavour qualities to cheese [4]. In peptidase family S8 (subtilisin family)" +"3.4.21.97","Involved in the breakdown of the scaffold protein during the late stages of assembly of the herpes-virus virion. Inhibited by diisopropyl fluorophosphate. Type example of peptidase family S21. Catalytic residues are His, Ser, His, a combination not known for any other peptidase, and the protein fold also is unique. Known from herpes viruses of several types, cytomegalovirus, Epstein-Barr virus and human herpesvirus 3" +"3.4.21.98","Encoded by the genome of the viruses of the hepatitis C group, and contributes to the maturation of the precursor polyproteins. The enzyme is greatly activated by binding of the 54-residue NS4A 'cofactor' protein also derived from the viral polyprotein. Type example of peptidase family S29. The crystallographic structure shows a chymotrypsin-like fold." +"3.4.21.99","The enzyme from the ascidian (Prochordate) Halocynthia roretzi is localized in the sperm head, and released during sperm activation. A proline-rich region is involved in binding to the vitelline coat of the egg. Belongs in peptidase family S1 (trypsin family)." +"3.4.21.100","An enzyme secreted by Pseudomonas sp. No. 101. Optimum pH is 4. It is distinguished from xanthomonapepsin by its insensitivity to EPNP and from scytalidopepsin B by this property and by its unrelated amino-acid sequence. Inhibited by tyrostatin, a peptide aldehyde [2]. Type example of peptidase family S53." +"3.4.21.101",Secreted by the bacterium Xanthomonas sp. Belongs in peptidase family S53. +"3.4.21.102","Proteolytic processing of the D1 protein of photosystem II is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation. The recognition of the substrate is mediated by a PDZ domain, a small protein module that promotes protein-protein interactions by binding to internal or C-terminal sequences of their partner proteins. Type example of peptidase family S41." +"3.4.21.103","Belongs in peptidase family S53. From the slime mold Physarum polycephalum. Is not inhibited by pepstatin, but is blocked by methyl 2-diazoacetamidohexanoate. Closely similar enzymes are found in Dictyostelium discoideum and P. flavicomum. Formerly included in EC 3.4.23.6." +"3.4.21.104","Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement [7]. This enzyme displays C_overbar_1s_-like esterolytic activity (cf. EC 3.4.21.42, complement subcomponent C_overbar_1s_). It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42 [3]. Belongs in peptidase family S1A." +"3.4.21.105","These endopeptidases are multi-spanning membrane proteins. Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains. A catalytic dyad is involved in proteolysis rather than a catalytic triad, as was thought previously [14]. They are important for embryo development in Drosophila melanogaster. Rhomboid is a key regulator of EGF receptor signalling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway. Belongs in peptidase family S54. Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Rhomboids are widely conserved from bacteria to archaea to humans [9,13]." +"3.4.22.1",An intracellular (lysosomal) enzyme in peptidase family C1 (papain family) +"3.4.22.2",Type example of peptidase family C1 from latex of the papaya (Carica papaya) fruit. Inhibited by compound E-64 and proteins of the cystatin family. +"3.4.22.3","The major proteolytic component of the latex of fig, Ficus glabrata. Cysteine endopeptidases with similar properties are present in other members of the large genus Ficus. In peptidase family C1 (papain family)." +"3.4.22.6",The major endopeptidase of papaya (Carica papaya) latex. It has multiple chromatographic forms. In peptidase family C1 (papain family). +"3.4.22.7","From the latex of milkweed, Asclepias syriaca. It has multiple forms, and is in peptidase family C1 (papain family)" +"3.4.22.8",From the bacterium Clostridium histolyticum. It requires Ca2+ ions and is inhibited by EDTA. Type example of peptidase family C11. +"3.4.22.10","From the bacterium, group A Streptococcus. Formed from the proenzyme by limited proteolysis. Type example of peptidase family C10." +"3.4.22.14",From the kiwi fruit or Chinese gooseberry (Actinidia chinensis). In peptidase family C1 (papain family) +"3.4.22.15",A lysosomal enzyme in peptidase family C1 (papain family) that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64 +"3.4.22.16",Present in lysosomes of mammalian cells. In peptidase family C1 (papain family) +"3.4.22.24",Degrades azocasein and denatured hemoglobin; the only native protein on which it has been shown to act is tyrosine aminotransferase +"3.4.22.25","From the papaya plant, Carica papaya. Not inhibited by chicken cystatin, unlike most other homologues of papain, but in peptidase family C1 (papain family)" +"3.4.22.26",Apparently produced only by malignant and fetal cells +"3.4.22.27",A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family) +"3.4.22.28","From entero-, rhino-, aphto- and cardioviruses. Larger than the homologous virus picornain 2A. Type example of peptidase family C3" +"3.4.22.29","From entero-, rhino-, aphto- and cardioviruses. Smaller than the homologous picornain 3C, which is also in peptidase family C3 (picornain 3C family)" +"3.4.22.30","From papaya plant, Carica papaya. In peptidase family C1 (papain family)" +"3.4.22.31","From stem of pineapple plant, Ananas comosus. Differs from stem and fruit bromelains in being inhibited by chicken cystatin. In peptidase family C1 (papain family)" +"3.4.22.32","The most abundant of the cysteine endopeptidases of the stem of the pineapple plant, Ananas comosus. Distinct from the bromelain found in the pineapple fruit (EC 3.4.22.33). Scarcely inhibited by chicken cystatin and also very slowly inactivated by {glossary/E64::E-64}. In peptidase family C1 (papain family)." +"3.4.22.33","From the pineapple plant, Ananas comosus. Scarcely inhibited by chicken cystatin. Another cysteine endopeptidase, with similar action on small molecule substrates, pinguinain, is obtained from the related plant, Bromelia pinguin, but pinguinain differs from fruit bromelain in being inhibited by chicken cystatin [4]." +"3.4.22.34","Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13" +"3.4.22.35","From the protozoan, Entamoeba histolytica. In peptidase family C1 (papain family)" +"3.4.22.36"," From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6,7]. Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor [6]. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mice, whereas caspase-4 enhances its activation in humans [7]. Belongs in peptidase family C14." +"3.4.22.37","A secreted endopeptidase from the bacterium Porphyromonas gingivalis. Strongly activated by glycine [1], and stabilized by Ca2+. Precursor molecule contains a hemagglutinin domain [2,3]. Misleadingly described in some literature as ""trypsin-like"", being a cysteine peptidase, type example of peptidase family C25." +"3.4.22.38","Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. In peptidase family C1 (papain family)" +"3.4.22.39","A cysteine endopeptidase from adenoviruses, the type example of peptidase family C5, with a protein fold unlike that known for any other peptidase [2]. Activity is greatly stimulated by the binding to the enzyme of an 11-residue peptide from the adenovirus capsid protein pre-VI at a site separate from the active site [1]" +"3.4.22.40","The molecule is a homohexamer in which the monomers have a papain-like tertiary structure (in peptidase family C1). The active sites are on the walls of a central channel through the molecule, and access of substrate molecules to them is obstructed by this and by the C-terminus of each polypeptide chain [3]. Bleomycin can scarcely be the natural substrate, and there are reports of limited endopeptidase activity. Known from bacteria as well as eukaryotic organisms. Hydrolase H from chicken muscle has many similarities to bleomycin hydrolase, but hydrolyses Ph-CO-Arg-2-naphthylamine as well as aminopeptidase substrates [2]." +"3.4.22.41","Cathepsin F is a lysosomal cysteine endopeptidase of family C1 (papain family), most active at pH 5.9. The enzyme is unstable at neutral pH values and is inhibited by compound E-64. Cathepsin F is expressed in most tissues of human, mouse and rat. Human gene locus: 11q13.1-13.3" +"3.4.22.42",Cathepsin O is a lysosomal cysteine peptidase of family C1 (papain family). The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32 +"3.4.22.43","Cathepsin V is a human lysosomal cysteine endopeptidase of family C1 (papain family) that is maximally active at pH 5.7 and unstable at neutral pH. Compound E-64, leupeptin and chicken cystatin are inhibitors. Human cathepsin V shows expression restricted to thymus, testis, corneal epithelium and some colon and breast carcinomas. Human gene locus: 9q22.2" +"3.4.22.44","The potyviruses cause diseases in plants, and inclusion bodies appear in the host cell nuclei; protein a of the inclusion bodies is the endopeptidase. The enzyme finds practical use when encoded in vectors for the artificial expression of recombinant fusion proteins, since it can confer on them the capacity for autolytic cleavage. It is also reported that transgenic plants expressing the enzyme are resistant to viral infection. Type example of peptidase family C4." +"3.4.22.45","Known from many potyviruses. The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities: the N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. Type example of peptidase family C6." +"3.4.22.46","Best known from foot-and-mouth disease virus, but occurs in other aphthoviruses and cardioviruses. Destruction of initiation factor eIF-4G has the effect of shutting off host-cell protein synthesis while allowing synthesis of viral proteins to continue. The tertiary structure reveals a distant relationship to papain and, consistent with this, compound E-64 is inhibitory. Type example of peptidase family C28." +"3.4.22.47",Activity is stimulated by glycine. Known from the bacterium Porphyromonas gingivalis and contributes to the pathogenicity of the organism. In peptidase family C25. +"3.4.22.48",Known from species of Staphylococcus. Type example of peptidase family C47. +"3.4.22.49","In both budding yeast and human cells, cleavage of the cohesin subunit Scc1 by separase is required for sister chromatid separation in mitosis. Budding yeast separase is also known to cleave the Rec8 subunit of a meiotic cohesin complex and the kinetochore protein Slk19. Type example of peptidase family C50." +"3.4.22.50",In peptidase family C1. Contributes to the liquefaction of the tissues of the insect host in the late stages of infection by the baculovirus. +"3.4.22.51",In peptidase family C1. Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins. +"3.4.22.52","In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.53, calpain-2." +"3.4.22.53","Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52, calpain-1." +"3.4.23.1","The predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis. Human pepsin A occurs in five molecular forms. Pig pepsin D [1,2] is unphosphorylated pepsin A. Type example of peptidase family A1." +"3.4.23.2",Formed from pig pepsinogen B. In peptidase family A1 (pepsin A family) +"3.4.23.3","Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin [6]. In peptidase family A1 (pepsin A family)." +"3.4.23.4","Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family)" +"3.4.23.5","Occurs intracellularly, in lysosomes. A zymogen form is known [4]. In peptidase family A1 (pepsin A family)." +"3.4.23.12","From the insectivorous plants Nepenthes spp. (secretions) and Drosera peltata (ground-up leaves). Aspartic endopeptidases are probably present in many other plants, including Lotus [3] and sorghum [2]. In peptidase family A1 (pepsin A family)" +"3.4.23.15",Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family). +"3.4.23.16","Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2" +"3.4.23.17",A 70 kDa membrane-bound enzyme isolated from cattle pituitary secretory vesicle. +"3.4.23.18","Found in a variety of Aspergillus species (imperfect fungi): Aspergillus awamori (awamorin, aspergillopepsin A: [8]), A. foetidus (aspergillopepsin F: [6]), A. fumigatus [7], A. kawachii [9], A. niger (proteinase B, proctase B: [2,4]), A. oryzae (trypsinogen kinase: [3,10]), A. saitoi (aspergillopeptidase A: [10]), and A. sojae [5,10]. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6" +"3.4.23.19","Isolated from Aspergillus niger var. macrosporus, distinct from proteinase B (see aspergillopepsin I) in specificity and insensitivity to pepstatin. In peptidase family G1 (scytalidopepsin B family). Formerly included in EC 3.4.23.6" +"3.4.23.20",From the imperfect fungus Penicillium janthinellum. In peptidase family A1 (pepsin A family). Closely related enzymes have been isolated from P. roqueforti [2] and P. duponti [3]. +"3.4.23.21",From the zygomycete fungus Rhizopus chinensis. A similar endopeptidase is found in R. niveus [2]. In peptidase family A1 (pepsin A family). +"3.4.23.22",From the ascomycete Endothia parasitica. In peptidase family A1 (pepsin A family). +"3.4.23.23",Isolated from the zygomycete fungi Mucor pusillus and M. miehei. The two species variants show 83% sequence identity and are immunologically crossreactive. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6 +"3.4.23.24","This endopeptidase from the imperfect yeast Candida albicans is inhibited by pepstatin, but not by methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenoxy)propane. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6" +"3.4.23.25",Located in the vacuole of the baker's yeast (Saccharomyces cerevisiae) cell. In peptidase family A1 (pepsin A family). +"3.4.23.26","From the imperfect yeast Rhodotorula glutinis. Somewhat similar enzymes have been isolated from the imperfect yeast-like organism Cladosporium sp. [4,6] and the imperfect fungus Paecilomyces varioti [1,2]." +"3.4.23.28",From the imperfect fungus Acrocylindrium sp. Has a very low pH optimum on casein of 2.0. In peptidase family A1 (pepsin A family). +"3.4.23.29",From the basidiomycete Polyporus tulipiferae (formerly Irpex lacteus). In peptidase family A1 (pepsin A family) +"3.4.23.30","From the basidiomycete Pycnoporus sanguineus, formerly known as P. coccineus and Trametes sanguinea. Formerly included in EC 3.4.23.6" +"3.4.23.31","Isolated from the imperfect fungus Scytalidium lignicolum. Not inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or 1,2-epoxy-3-(p-nitrophenyl)propane. A related enzyme from the same organism, proteinase C, is also insensitive to these inhibitors and has Mr = 406,000 [3]" +"3.4.23.32","A second endopeptidase from Scytalidium lignicolum (see scytalidopepsin A) that is insensitive to pepstatin and methyl 2-diazoacetamidohexanoate. 1,2-Epoxy-3-(p-nitrophenoxy)propane reacts with Glu53, which replaces one of the aspartic residues at the active centre. One of the smallest aspartic endopeptidases active as the monomer, with Mr 22,000. Similarly inhibitor-resistant endopeptidases are found in the basidiomycetes Lentinus edodes [1] and Ganoderma lucidum [3], and in Polyporus tulipiferae [4], a second endopeptidase distinct from polyporopepsin, but these are of typical aspartic endopeptidase size, Mr about 36,000. Type example of peptidase family G1." +"3.4.23.34","Found in stomach, spleen, erythrocyte membrane; not lysosomal. Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation or reduction produces monomer. In peptidase family A1 (pepsin A family)" +"3.4.23.35",A secreted endopeptidase known from baker's yeast (Saccharomyces cerevisiae). In peptidase family A1 (pepsin A family) +"3.4.23.36",An 18-kDa enzyme present in bacterial inner membranes. Inhibited by pepstatin and the antibiotic globomycin. Type example of peptidase family A8. +"3.4.23.38","Known from the malaria organism, Plasmodium. About 37 kDa. In peptidase family A1 (pepsin A family), closest to cathepsin D and renin in structure. Inhibited by pepstatin. Formerly included in EC 3.4.23.6" +"3.4.23.39","Known from the malaria organism, Plasmodium. About 37 kDa. In peptidase family A1 (pepsin A family), and is 73% identical in sequence to plasmepsin I. Inhibited by pepstatin. Formerly included in EC 3.4.23.6" +"3.4.23.40","Known particularly from barley grain, but present in other plants also. In peptidase family A1 (pepsin A family), but structurally distinct in containing an internal region of about 100 amino acids not generally present in the family" +"3.4.23.41","In peptidase family A1 of pepsin, and weakly inhibited by pepstatin. Can partially substitute for kexin in a deficient strain of yeast. The homologous product of the Mkc7 gene (Saccharomyces cerevisiae) has similar catalytic activity and has been termed yapsin 2 [2]" +"3.4.23.42",From the thermophilic archaeon Sulfolobus acidocaldarius. Maximally active at pH 2 and 90 _degree_C. Weakly inhibited by pepstatin but shows no sequence similarity to pepsin. Type example of peptidase family A5. +"3.4.23.43","Many species of bacteria carry pili on their cell surfaces. These are virulence determinants in pathogenic strains, and are assembled biosynthetically from type IV prepilin subunits. Before assembly, the prepilin molecules require proteolytic processing, which is done by the prepilin peptidase. Prepilin peptidase and its homologues play a central role not only in type IV pilus biogenesis but also in transport of macromolecules across cell membranes. Although both peptide-bond hydrolysis and N-methylation are catalysed by the same molecule, the methylation can be inhibited without affecting peptidase activity, and it is believed that the enzyme has two separate catalytic sites. Type example of peptidase family A24." +"3.4.23.44","A single aspartic residue is critical for activity, and inhibition by EDTA indicates that a metal ion is also important. The enzyme is known from several nodaviruses that are pathogens of insects. Type example of peptidase family A6, and structurally related to the tetravirus endopeptidase in family A21, although in that family, the catalytic residue is thought to be Glu." +"3.4.23.45","Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain." +"3.4.23.46","Suggested to be the major ""beta-secretase"" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain." +"3.4.23.47",In peptidase family A2. Responsible for the post-translational processing of the human immunodeficiency virus polyprotein. +"3.4.23.48",In peptidase family A26. From the bacterium Yersinia pestis that causes plague. +"3.4.24.1","A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins in the venom of western diamondback rattlesnake. The 60 kDa hemorrhagic toxin 1 of Crotalus ruber ruber shows identical specificity [2]. In peptidase family M12 (astacin family). Related metalloendopeptidases from rattlesnake venoms are EC 3.4.24.41 (atrolysin B), EC 3.4.24.42 (atrolysin C), EC 3.4.24.43 (atroxase), EC 3.4.24.44 (atrolysin E), EC 3.4.24.45 (atrolysin F), EC 3.4.24.46 (adamalysin), EC 3.4.24.47 (horrilysin), and EC 3.4.24.48 (ruberlysin)" +"3.4.24.3","Six species of metalloendopeptidase acting on native collagen can be isolated from the medium of Clostridium histolyticum. Class I has forms alpha (68 kDa), beta (115 kDa) and gamma (79 kDa); class II has delta (100 kDa), epsilon (110 kDa) and zeta (125 kDa). The two classes are immunologically crossreactive, but have significantly different sequences, and different specificities such that their actions on collagen are complementary. The enzymes also act as peptidyl-tripeptidases. Variants of the enzyme have been purified from Bacillus cereus [10], Empedobacter collagenolyticum [4], Pseudomonas marinoglutinosa [1], and species of Vibrio, Vibrio B-30 (ATCC 21250) [2] and V. alginolyticus (previously Achromobacter iophagus) [3,8]. Also known from Streptomyces sp. [9]. The Vibrio enzyme is the type example of peptidase family M9." +"3.4.24.6",From the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma). +"3.4.24.7","The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, alpha-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10" +"3.4.24.11",A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13 +"3.4.24.12",A glycoprotein from various members of the class Echinoidea. Extracellular enzyme requiring Ca2+. In peptidase family M10 (interstitial collagenase family) +"3.4.24.13","A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC 3.4.21.72, IgA-specific serine endopeptidase)" +"3.4.24.14",Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family) +"3.4.24.15",Thiol compounds activate at low concentrations. Type example of peptidase family M3. +"3.4.24.16","No absolute requirement for a prolyl bond: the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. In peptidase family M3 (thimet oligopeptidase family)" +"3.4.24.17","An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family)" +"3.4.24.18","A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts. Differences from neprilysin (EC 3.4.24.11) (astacin family). Formerly included in EC 3.4.24.11" +"3.4.24.19",A 100 kDa endopeptidase the activity of which is increased by Ca2+ and by an enhancer glycoprotein. In peptidase family M12 (astacin family) +"3.4.24.20",From the honey fungus Armillaria mellea. In peptidase family M35 (deuterolysin family). +"3.4.24.21",A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12. +"3.4.24.22","In peptidase family M10 (interstitial collagenase family). Digests gelatin types I, III, IV, V, fibronectin and proteoglycan" +"3.4.24.23","Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll" +"3.4.24.24","A secreted endopeptidase in peptidase family M10 (interstitial collagenase family), but possessing an additional fibronectin-like domain" +"3.4.24.25","Thermostable enzyme from Vibrio proteolyticus (formerly Aeromonas proteolytica). Specificity related to, but distinct from, those of thermolysin and bacillolysin [1]. A zinc metallopeptidase in family M4 (thermolysin family). Formerly included in EC 3.4.24.4" +"3.4.24.26","In peptidase family M4 (thermolysin family). From the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage." +"3.4.24.27"," A thermostable extracellular metalloendopeptidase containing four calcium ions. Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus [4] and Aspergillus oryzae [5]. Type example of peptidase family M4. Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin" +"3.4.24.28","Variants of this enzyme have been found in species of Bacillus including B. subtilis [1,6], B. amyloliquefaciens [5], B. megaterium (megateriopeptidase, [2]), B. mesentericus [10], B. cereus [3,8,9] and B. stearothermophilus [7]. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4" +"3.4.24.29",A metalloenzyme from S. aureus earlier confused with staphylokinase (a non-enzymic activator of plasminogen). +"3.4.24.30","A 30 kDa endopeptidase found intracellularly in S. thermophilus [1] and S. diacetilactis [2] and in the medium of S. faecalis [3,4]. In peptidase family M4 (thermolysin family). Formerly included in EC 3.4.24.4" +"3.4.24.31","The enzyme has been characterized from the bacteria Streptomyces griseus, Streptomyces naraensis, and Streptomyces cacaoi. Specificity is similar to that of thermolysin, but the enzyme is much more sensitive to inhibition by sulfanylacetyl-Phe-Leu. Little structural similarity to other bacterial metalloendopeptidases. Type example of peptidase family M5." +"3.4.24.32",From Achromobacter lyticus and Lysobacter enzymogenes. Digests bacterial cell walls. Type example of peptidase family M23. +"3.4.24.33",A metalloenzyme isolated from Pseudomonas fragi. Useful in protein sequencing applications because of its limited specificity. In peptidase family M72. +"3.4.24.34","Similar to interstitial collagenase in specificity, but the product of a different gene and highly glycosylated. Stored in the specific granules of neutrophil leukocytes. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.7" +"3.4.24.35","Similar to gelatinase A, but possesses a further domain . In peptidase family M10 (interstitial collagenase family)" +"3.4.24.36",A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans. Contains consensus sequence for a zinc-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The enzyme can activate its proenzyme by cleavage of the Val100!Val bond. An acid pH optimum is found with certain protein substrates. Type example of peptidase family M8 +"3.4.24.37",An 83 kDa cytoplasmic thiol-dependent metalloendopeptidase from Saccharomyces cerevisiae. In peptidase family M3 (thimet oligopeptidase family). +"3.4.24.38","A glycoprotein found in the periplasmic space of Chlamydomonas reinhardtii gametes in a 62 kDa inactive form; decreased to 60 kDa upon activation. A zinc enzyme, inhibited by phosphoramidon, but also thiol activated. Type example of peptidase family M11" +"3.4.24.39","Proteolytic activity found in Penicillium roqueforti [4], P. caseicolum [4], Aspergillus sojae [3] and A. oryzae [1,5]. Optimum pH of 5 for digesting various proteins. Strong action on protamine and histones. Insensitive to phosphoramidon. About 20 kDa. A distinct Aspergillus sojae endopeptidase is larger and has a neutral pH optimum. Type example of peptidase family M35. Formerly included in EC 3.4.24.4" +"3.4.24.40","A 50 kDa extracellular endopeptidase from Pseudomonas aeruginosa [1,2,6], Escherichia freundii [3], Serratia marcescens [4,5,6] and Erwinia chrysanthemi [7]. There is broad specificity in cleavage of the insulin B chain, with some species variations. The pH optimum for digesting various proteins is about 9 - 10. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.4" +"3.4.24.41",From the venom of the western diamondback rattlesnake (Crotalus atrox). In peptidase family M12 (astacin family) +"3.4.24.42","A 24 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests type IV collagen, and exists as two forms, c and d. Phosphoramidon inhibits in the 0.1 mM range. In peptidase family M12 (astacin family). Hemorrhagic toxin-2 of C. ruber ruber has the same Mr and specificity and is a homologue [4,6]." +"3.4.24.43",A nonhemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that cleaves fibrinogen. In peptidase family M12 (astacin family) +"3.4.24.44","A 25.7 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests basement membrane components, including the triple helix of type IV collagen. Such action is believed to contribute to the hemorrhagic property by weakening capillary walls. In peptidase family M12 (astacin family)" +"3.4.24.45","A 64 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests the gamma chain of fibrinogen. Immunologically distinct from EC 3.4.24.1, atrolysin A." +"3.4.24.46",From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate alpha1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family) +"3.4.24.47","A 56 kDa hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus) that cleaves basement membrane, hide powder and fibrinogen." +"3.4.24.48",A 25 kDa hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen. In peptidase family M12 (astacin family) +"3.4.24.49",Caseinolytic endopeptidase of jararaca snake (Bothrops jararaca) venom; 48 kDa. In peptidase family M12 +"3.4.24.50","A 22.5 kDa endopeptidase from the venom of the jararaca snake (Bothrops jararaca), insensitive to phosphoramidon at 0.5 mM. In peptidase family M12 (astacin family)" +"3.4.24.51",A 70 kDa endopeptidase from the venom of the king cobra (Ophiophagus hannah) +"3.4.24.52",A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family) +"3.4.24.53",A 24 kDa nonhemorrhagic endopeptidase from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family) +"3.4.24.54",A 94 kDa hemorrhagic and fibrinogenolytic endopeptidase from the Chinese habu snake (Trimeresurus mucrosquamatus) venom. In peptidase family M12 (astacin family) +"3.4.24.55","From the periplasmic space of Escherichia coli. Inhibited by EDTA and 1,10-phenanthroline; not thiol-dependent. Type example of peptidase family M16" +"3.4.24.56","A 110 kDa cytosolic enzyme, known from mammals and the fruit fly, Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family)." +"3.4.24.57","An enzyme secreted by the bacterium Pasteurella haemolytica. Inhibited by EDTA (100 mM) and 1,10-phenanthroline. Type example of peptidase family M22" +"3.4.24.58",This enzyme from the venom of Russell's viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family) +"3.4.24.59",A homologue of thimet oligopeptidase. Natural substrates are precursor proteins that have already been processed by mitochondrial processing peptidase. In peptidase family M3 (thimet oligopeptidase family) +"3.4.24.60","An endopeptidase of 100 kDa secreted from the skin of the amphibian, Xenopus laevis (Dactyletre du Cap). Resembles neprilysin in insensitivity to 1 muM captopril, but differs from it in being insensitive to thiorphan (1 muM) and unable to digest [Met5]enkephalin, [Leu5]enkephalin, oxytocin, and substance P-(7-11)-peptide. A similar endopeptidase is found in human neuroblastoma cells [2]" +"3.4.24.61","Enzyme of 133 kDa from rat brain and testis. A homologue of pitrilysin containing the His-Phe-Leu-Glu-His zinc-binding sequence, and a highly acidic stretch of 71 residues. Unusually for a metalloendopeptidase, inhibited by bestatin, amastatin and N-ethylmaleimide. In peptidase family M16 (pitrilysin family)" +"3.4.24.62","An endopeptidase of 58 kDa known from bovine pituitary neurosecretory granules and bovine and human corpus luteum [4,5]. Inhibited by EDTA [1]" +"3.4.24.63","A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)" +"3.4.24.64","Known from the mitochondrial matrix of fungi and mammals. Formed from two subunits, both homologous with pitrilysin [3], and the products of the MAS1 and MAS2 genes in yeast. In peptidase family M16 (pitrilysin family)." +"3.4.24.65",This enzyme is synthesized as a proenzyme of 53 kDa that is converted to an active form of 22 kDa. cDNA sequences have been obtained for the mouse [3] and human [4] enzymes. In peptidase family M10 (interstitial collagenase family) +"3.4.24.66",Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin H. A 24 kDa peptidase family M12 (astacin family) +"3.4.24.67",Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin L. A 25.5 kDa peptidase in family M12 (astacin family) +"3.4.24.68","Zinc enzyme produced by Clostridium tetani. Proenzyme of 150 kDa is processed to disulfide-linked subunits of 100 and 50 kDa, the latter being responsible for the endopeptidase activity. Weakly inhibited by captopril, and phosphoramidon. The clostridial neurotoxins disable the neuroexocytosis apparatus, and have been described as the most toxic substances known. Tentoxilysin acts at the spinal inhibitory interneurons, blocking the release of various neurotransmitters to produce spastic paralysis. Type example of peptidase family M27 (tentoxilysin family)" +"3.4.24.69","This zinc enzyme, produced by Clostridium botulinum, occurs as forms A-G that differ in specificity of action on the proteins of the neuroexocytosis apparatus [1-5]. The 150-kDa proenzymes of bontoxilysin are processed to disulfide-linked subunits of 100 and 50 kDa, the latter being responsible for the endopeptidase activities. Weakly inhibited by captopril, and phosphoramidon. Toxicity is due to action at the neuromuscular junctions that blocks release of acetylcholine, causing flaccid paralysis, in contrast to the spastic paralysis caused by tentoxilysin. In peptidase family M27 (tentoxilysin family)" +"3.4.24.70","Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase, in peptidase family M3 (thimet oligopeptidase family), but differs from thimet oligopeptidase in lack of thiol-activation" +"3.4.24.71","A phosphoramidon-sensitive metalloendopeptidase in peptidase family M13 (neprilysin family). An integral membrane protein predominantly of endothelial cells, which generates the potent vasoconstrictor endothelin 1 from its inactive precursor" +"3.4.24.72","A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake (Agkistrodon contortix contortix). In peptidase family M12 (astacin family)" +"3.4.24.73",Hemorrhagic endopeptidase from the venom of the jararaca snake (Bothrops jararaca). The 52-kDa enzyme contains a disintegrin domain [3]. In peptidase family M12 (astacin family) +"3.4.24.74","Thought to be a cause of diarrhoea in animals and humans. Hydrolyses extracellular matrix proteins, and disrupts tight junctions of intestinal epithelial cells. Also degrades intracellular, cytoskeletal proteins actin, myosin and others. In peptidase family M10 (interstitial collagenase family)" +"3.4.24.75","A zinc-dependent, 25-kDa endopeptidase from Staphylococcus simulans. Lyses cells of S. aureus, in particular, by its action on the cross-bridges of the cell wall. Type example of peptidase family M23." +"3.4.24.76","A zinc metalloendopeptidase in peptidase family M12 (astacin family), secreted by the bacterium Flavobacterium meningosepticum . The specificity is similar to that of EC 3.4.24.33, peptidyl-Asp metalloendopeptidase from Pseudomonas fragi but the two are reported to be structurally dissimilar" +"3.4.24.77",Type example of peptidase family M7. +"3.4.24.78","Initiates the degradation of small, acid-soluble proteins during spore germination in Bacillus megaterium. Type example of peptidase family A25." +"3.4.24.79","A 400-kDa disulfide-linked dimer. Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. In peptidase family M43." +"3.4.24.80","In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces." +"3.4.24.81","In peptidase family M12. Partially responsible for the ""alpha-secretase"" activity in brain that degrades the potentially harmful beta-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling." +"3.4.24.82",In peptidase family M12. Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix. +"3.4.24.83","From the bacterium Bacilus anthracis that causes anthrax. One of three proteins that are collectively termed anthrax toxin. Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. In peptidase family M34." +"3.4.24.84","The enzyme hydrolyses proteins that terminate with a CaaX motif in which C is an S-isoprenylated cysteine residue, a is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.The enzyme, which is the Type example of peptidase family M48, is one of two enzymes that can catalyse this processing step for mating a-factor in yeast. Subsequently, the S-isoprenylated cysteine residue that forms the new C-terminus is methyl-esterified and forms a hydrophobic membrane-anchor. Differs from EC 3.4.26.1, intramembrane prenyl-peptidase Rce1, in its catalytic mechanism and substrate preference." +"3.4.24.85","Type example of peptidase family M50. The transcription factors SREBP-1 and -2 are synthesized as precursor proteins that are attached to the membranes of the endoplasmic reticulum and two cleavages are needed to release the active factor so that it can move to the nucleus. This enzyme cleaves the second of these, and is thus the ""site 2 protease"", S2P." +"3.4.24.86","In peptidase family M12. In vivo, the cleavage of tumour necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation." +"3.4.25.1","A 20-S protein composed of 28 subunits arranged in four rings of seven. The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity. In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. The molecule is barrel-shaped, and the active sites are on the inner surfaces. Terminal apertures restrict access of substrates to the active sites. There is evidence that catalytic subunits are replaced by others under some conditions so as to alter the specificity of proteolysis, perhaps optimizing it for the formation of antigenic peptides. A complex of the 20-S proteasome endopeptidase complex with a 19-S regulatory unit is the 26-S proteasome that degrades ubiquitin-protein conjugates. Type example of peptidase family T1." +"4.1.1.1",A thiamine-diphosphate protein. Also catalyses acyloin formation. +"4.1.1.2","The enzyme from Bacillus subtilis contains manganese and requires O2 for activity, even though there is no net redox change." +"4.1.1.3",The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+. +"4.1.1.6","The enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase." +"4.1.1.7",A thiamine-diphosphate protein. +"4.1.1.8",A thiamine-diphosphate protein. +"4.1.1.9",Specific for malonyl-CoA. The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 2.8.3.3 malonate CoA-transferase. +"4.1.1.11",The Escherichia coli enzyme contains a pyruvoyl group. +"4.1.1.12","A pyridoxal-phosphate protein. Also catalyses the decarboxylation of aminomalonate (formerly listed as EC 4.1.1.10), and the desulfination of 3-sulfino-L-alanine to sulfite and alanine." +"4.1.1.14",A pyridoxal-phosphate protein. Also acts on L-leucine. +"4.1.1.15","A pyridoxal-phosphate protein. The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate." +"4.1.1.16",A pyridoxal-phosphate protein. +"4.1.1.17",A pyridoxal-phosphate protein. +"4.1.1.18",A pyridoxal-phosphate protein. Also acts on 5-hydroxy-L-lysine. +"4.1.1.19",A pyridoxal-phosphate protein. +"4.1.1.20",A pyridoxal-phosphate protein. +"4.1.1.21","While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate." +"4.1.1.22",The enzyme from animal tissues contains a pyridoxal 5'-phosphate cofactor. The bacterial enzyme contains a tightly-bound pyruvoyl cofactor. +"4.1.1.23",The enzyme from higher eukaryotes is identical with EC 2.4.2.10 orotate phosphoribosyltransferase . +"4.1.1.24",A pyridoxal-phosphate protein. +"4.1.1.25","A pyridoxal-phosphate protein. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine." +"4.1.1.28","A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine." +"4.1.1.29",A pyridoxal-phosphate protein. Also acts on L-cysteate. The 1992 edition of the Enzyme List erroneously gave the name sulfoalanine decarboxylase to this enzyme. +"4.1.1.31","This enzyme replenishes oxaloacetate in the tricarboxylic acid cycle when operating in the reverse direction. The reaction proceeds in two steps: formation of carboxyphosphate and the enolate form of pyruvate, followed by carboxylation of the enolate and release of phosphate." +"4.1.1.32",ITP can act as phosphate donor. +"4.1.1.35",Requires NAD+. +"4.1.1.37",Acts on a number of porphyrinogens. +"4.1.1.38",Also catalyses the reaction: phosphoenolpyruvate + phosphate = pyruvate + diphosphate. +"4.1.1.39","Will utilize O2 instead of CO2, forming 3-phospho-D-glycerate and 2-phosphoglycolate." +"4.1.1.41","The enzyme from Veillonella alcalescens is a biotinyl-protein, requires Na+ and acts as a sodium pump." +"4.1.1.42",Requires ATP. +"4.1.1.43","The enzyme from the bacterium Azospirillum brasilense also acts on some other substrates, including (indol-3-yl)pyruvate, with much lower efficiency. However, it only possesses classical Michaelis-Menten kinetics with phenylpyruvate. Aliphatic 2-oxo acids longer that 2-oxohexanoate are not substrates. cf. EC 4.1.1.74, indolepyruvate decarboxylase." +"4.1.1.45",Product rearranges non-enzymically to picolinate. +"4.1.1.47",A flavoprotein. +"4.1.1.48","In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)]." +"4.1.1.50",The Escherichia coli enzyme contains a pyruvoyl group. +"4.1.1.53",A pyridoxal-phosphate protein. Also acts on tyrosine and other aromatic amino acids. +"4.1.1.56",Also decarboxylates other C14 to C16 oxo acids. +"4.1.1.64","A pyridoxal-phosphate protein. Acts on 2-amino-2-methylpropanoate (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and 1-aminocyclopentanecarboxylate." +"4.1.1.65",The enzyme contains a tightly-bound pyruvoyl cofactor. +"4.1.1.68","Requires Mg2+ [2,3]. Part of the 4-hydroxyphenylacetate degradation pathway in Escherichia coli. " +"4.1.1.70","The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme." +"4.1.1.71",Requires thiamine diphosphate. Highly specific. +"4.1.1.72","Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids." +"4.1.1.74",Thiamine diphosphate- and Mg2+-dependent. More specific than EC 4.1.1.1 pyruvate decarboxylase +"4.1.1.75",Enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation. +"4.1.1.77","Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enzyme has been reported to accept multiple tautomeric forms [1-4]. However, careful analysis of the stability of the different tautomers, as well as characterization of the enzyme that produces its substrate, EC 5.3.2.6, 2-hydroxymuconate tautomerase, showed that the actual substrate for the enzyme is (3E)-2-oxohex-3-enedioate [4]." +"4.1.1.78","The mechanism appears to involve hydration of the acetylene and decarboxylation of the oxaloacetic acid formed, although free oxaloacetate is not an intermediate. It is thus analogous to EC 4.2.1.27 (acetylenecarboxylate hydratase) in its mechanism." +"4.1.1.79",Requires thiamine diphosphate. Does not decarboxylate pyruvate or phosphonopyruvate. The enzyme appears to be oxygen-sensitive. +"4.1.1.80",Reacts with dopamine to give the benzylisoquinoline alkaloid skeleton. +"4.1.1.81","A pyridoxal-phosphate protein. This enzyme is unable to decarboxylate the D-isomer of threonine O-3-phosphate. The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of EC 6.3.1.10, adenosylcobinamide-phosphate synthase, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway." +"4.1.1.82","The enzyme catalyses a step in the biosynthetic pathway of 2-aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Requires thiamine diphosphate and Mg2+ as cofactors. The enzyme is activated by the divalent cations Mg2+, Ca2+ and Mn2+. Pyruvate and sulfopyruvate can also act as substrates, but more slowly. This enzyme drives the reaction catalysed by EC 5.4.2.9, phosphoenolpyruvate mutase, in the thermodynamically unfavourable direction of 3-phosphonopyruvate formation [2]. It is the initial step in all of the major biosynthetic pathways of phosphonate natural products [3]." +"4.1.1.83","The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product. The enzyme is a glycyl radical enzyme." +"4.1.1.84","This enzyme is specific for D-dopachrome as substrate and belongs to the MIF (macrophage migration inhibitory factor) family of proteins. L-Dopachrome, L- or D-alpha-methyldopachrome and dopaminochrome do not act as substrates (see also EC 5.3.3.12, L-dopachrome isomerase)" +"4.1.1.85","Requires Mg2+. Along with EC 5.1.3.22, L-ribulose-5-phosphate 3-epimerase, this enzyme is involved in a pathway for the utilization of L-ascorbate by Escherichia coli." +"4.1.2.5","A pyridoxal-phosphate protein. This enzyme is specific for L-threonine and can not utilize L-allo-threonine. Different from EC 4.1.2.49, L-allo-threonine aldolase, and EC 4.1.2.48, low-specificity L-threonine aldolase." +"4.1.2.9",A thiamine-diphosphate protein. +"4.1.2.10","A variety of enzymes from different sources and with different properties. Some are flavoproteins, others are not. Active towards a number of aromatic and aliphatic hydroxynitriles (cyanohydrins)." +"4.1.2.11","Does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 [(R)-mandelonitrile lyase], EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile lyase]." +"4.1.2.13","Also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc." +"4.1.2.14","The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D-galactonate. cf. EC 4.1.2.55, 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase [2]. Also acts on 2-oxobutanoate [1]." +"4.1.2.21","The enzyme catalyses the last reaction in a D-galactose degradation pathway. cf. EC 4.1.2.55, 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase." +"4.1.2.22",Also acts on D-xylulose 5-phosphate. +"4.1.2.24","Acts on various N,N-dialkylarylamides." +"4.1.2.25","The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyse the epimerisation of the 2' hydroxy-group (EC 5.1.99.8, 7,8-dihydroneopterin epimerase) [2,3]. The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyses EC 5.1.99.8 and EC 1.13.11.81, 7,8-dihydroneopterin oxygenase [6]. The enzyme from the yeast Saccharomyces cerevisiae also catalyses the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3, 2-amino-4-hydroxy-6-(hydroxymethyl)dihydropteridine diphosphokinase, and EC 2.5.1.15, dihydropteroate synthase [4]." +"4.1.2.26",A pyridoxal-phosphate protein. +"4.1.2.27",A pyridoxal-phosphate protein. +"4.1.2.30","A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter [2]." +"4.1.2.33",The insect enzyme is involved in the conversion of sitosterol into cholesterol. +"4.1.2.34","Involved, with EC 1.13.11.38 (1-hydroxy-2-naphthoate 1,2-dioxygenase), in the metabolism of phenanthrene in bacteria." +"4.1.2.37","This enzyme accepts aliphatic and aromatic hydroxynitriles, unlike EC 4.1.2.11 (hydroxymandelonitrile lyase) which does not act on aliphatic hydroxynitriles. 2-Hydroxyisobutyronitrile (acetone cyanohydrin) is liberated by glycosidase action on linamarin." +"4.1.2.38",A thiamine-diphosphate protein. +"4.1.2.39","The enzyme from Hevea (rubber tree) and Manihot spp. (cassava) accepts aliphatic and aromatic hydroxynitriles, unlike EC 4.1.2.11 (hydroxymandelonitrile lyase) which does not act on aliphatic hydroxynitriles. 2-Hydroxyisobutyronitrile (acetone cyanohydrin) is liberated by glycosidase action on linamarin." +"4.1.2.40",Enzyme activity is stimulated by certain divalent cations. It is involved in the tagatose 6-phosphate pathway of lactose catabolism in bacteria. +"4.1.2.41","This is one of the activities of a bifunctional enzyme, trans-feruloyl-CoA hydratase/lyase, that converts trans-feruloyl-CoA to vanillin. The other activity is EC 4.2.1.101 trans-feruloyl-CoA hydratase. Vanillin is converted to vanillate by EC 1.2.1.67 vanillin dehydrogenase." +"4.1.3.1","The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate [3]." +"4.1.3.3","This enzyme is involved in the degradation of N-acetylneuraminate. It is specific for the open form of the sugar. It also acts on N-glycoloylneuraminate and on O-acetylated sialic acids, other than 4-O-acetylated derivatives." +"4.1.3.6","The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10 (citrate CoA-transferase) and EC 4.1.3.34 (citryl-CoA lyase). EC 3.1.2.16, citrate lyase deacetylase, deacetylates and inactivates the enzyme." +"4.1.3.14","A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans NCIMB 8944, is strictly specific for the L-erythro stereoisomer of 3-hydroxyaspartate. Different from EC 4.1.3.41, erythro-3-hydroxy-D-aspartate aldolase. Requires a divalent cation." +"4.1.3.16","The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase." +"4.1.3.17","Requires a divalent metal ion [3]. This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), phthalate, syringate and 3,4,5-trihydroxybenzoate [1-3]. The enzyme from Pseudomonas straminea can also catalyse the activity of EC 4.1.3.16, 4-hydroxy-2-oxoglutarate aldolase, and the decarboxylation of oxaloacetate [3]." +"4.1.3.22","The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.11 (citramalate CoA-transferase) and EC 4.1.3.25 (citramalyl-CoA lyase)." +"4.1.3.24","The enzymes from Rhodobacter species catalyse a step in the ethylmalonyl-CoA pathway for acetate assimilation [3,5]. The enzyme from halophilic bacteria participate in the methylaspartate cycle and catalyse the reaction in the direction of malyl-CoA formation [6]. The enzyme from the bacterium Chloroflexus aurantiacus, which participates in the 3-hydroxypropanoate cycle for carbon assimilation, also has the activity of EC 4.1.3.25, (3S)-citramalyl-CoA lyase [2,4]. " +"4.1.3.25","Requires Mg2+ ions for activity [3]. The enzyme from the bacterium Clostridium tetanomorphum is a component of EC 4.1.3.22, citramalate lyase [2]. It also acts on (3S)-citramalyl thioacyl-carrier protein [2]. The enzyme from the bacterium Chloroflexus aurantiacus also has the activity of EC 4.1.3.24, malyl-CoA lyase [3]. It has no activity with (3R)-citramalyl-CoA (cf. EC 4.1.3.46, (R)-citramalyl-CoA lyase) [3]." +"4.1.3.26",Also acts on the hydroxy derivative of farnesoyl-CoA. +"4.1.3.27","The enzyme, found in plants, fungi and bacteria is composed of two parts, a glutaminase subunit and a lyase subunit. The glutaminase produces ammonia that is channeled to the lyase subunit. In the absence of the glutaminase, the lyase can convert ammonia and chorismate into anthranilate. In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)]. " +"4.1.3.30","The enzyme acts on threo-Ds-2-methylisocitrate, but not on threo-Ds-isocitrate, threo-DL-isocitrate or erythro-Ls-isocitrate." +"4.1.3.34",The enzyme is a component of EC 4.1.3.6 {[citrate (pro-3S)-lyase]}and EC 2.3.3.8 [ATP citrate synthase]. Also acts on (3S)-citryl thioacyl-carrier protein. +"4.1.3.36","This enzyme is involved in the synthesis of 1,4-dihydroxy-2-naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria), phylloquinone (vitamin K1 in plants), and many plant pigments. +The coenzyme A group is subsequently removed from the product by EC 3.1.2.28, 1,4-dihydroxy-2-naphthoyl-CoA hydrolase." +"4.1.3.38","A pyridoxal-phosphate protein. Forms part of the folate biosynthesis pathway. Acts on 4-amino-4-deoxychorismate, the product of EC 2.6.1.85, aminodeoxychorismate synthase, to form p-aminobenzoate." +"4.1.99.1","A pyridoxal-phosphate protein, requiring K+. The enzyme cleaves a carbon-carbon bond, releasing indole and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogues of L-cysteine, L-serine and other 3-substituted amino acids." +"4.1.99.2","A pyridoxal-phosphate protein. The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme also slowly catalyses similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine." +"4.1.99.3","A flavoprotein (FAD), containing a second chromophore group. The enzyme catalyses the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme." +"4.1.99.5","Contains a diiron center. Involved in the biosynthesis of alkanes. The enzyme from the cyanobacterium Nostoc punctiforme PCC 73102 is only active in vitro in the presence of ferredoxin, ferredoxin reductase and NADPH, and produces mostly C15 and C17 alkanes [2,3]. The enzyme from pea (Pisum sativum) produces alkanes of chain length C18 to C32 and is inhibited by metal-chelating agents [1]. The substrate for this enzyme is formed by EC 1.2.1.80, acyl-[acyl-carrier protein] reductase." +"4.1.99.11","A glycyl radical enzyme that is inhibited by benzyl alcohol, benzaldehyde, phenylhydrazine and is inactivated by oxygen." +"4.2.1.1","The enzyme catalyses the reversible hydration of dissolved CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. At least eight distinct classes exist and appear to have evolved independently. A large majority of the enzymes contain a metal cofactor. Zn2+ is the most prevalent, but Cd2+, Co2+, Fe2+, and Mn2+ are also found [8]." +"4.2.1.3","Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds." +"4.2.1.4","cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. Does not act on isocitrate." +"4.2.1.6","The enzyme shows no activity with D-gluconate [2]. cf. EC 4.2.1.140, gluconate/galactonate dehydratase. " +"4.2.1.11",Also acts on 3-phospho-D-erythronate. +"4.2.1.17","Acts in the reverse direction. With cis-compounds, yields (3R)-3-hydroxyacyl-CoA. cf. EC 4.2.1.74 long-chain-enoyl-CoA hydratase." +"4.2.1.20","A pyridoxal-phosphate protein. The alpha-subunit catalyses the conversion of 1-C-(indol-3-yl)glycerol 3-phosphate to indole and D-glyceraldehyde 3-phosphate (this reaction was included formerly under EC 4.1.2.8). The indole migrates to the beta-subunit where, in the presence of pyridoxal 5'-phosphate, it is combined with L-serine to form L-tryptophan. In some organisms this enzyme is part of a multifunctional protein that also includes one or more of the enzymes EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase). In thermophilic organisms, where the high temperature enhances diffusion and causes the loss of indole, a protein similar to the beta subunit can be found (EC 4.2.1.122). That enzyme cannot combine with the alpha unit of EC 4.2.1.20 to form a complex." +"4.2.1.22","A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses beta-replacement reactions between L-serine, L-cysteine, cysteine thioethers, or some other beta-substituted alpha-L-amino acids, and a variety of mercaptans." +"4.2.1.24","The enzyme catalyses the asymmetric condensation and cyclization of two 5-aminolevulinate molecules, which is the first common step in the biosynthesis of tetrapyrrole pigments such as porphyrin, chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430. The enzyme is widespread, being essential in organisms that carry out respiration, photosynthesis, or methanogenesis. The enzymes from most organisms utilize metal ions (Zn2+, Mg2+, K+, and Na+) as cofactors that reside at multiple sites, including the active site and allosteric sites. Enzymes from archaea, yeast, and metazoa (including human) contain Zn2+ at the active site. In humans, the enzyme is a primary target for the environmental toxin Pb. The enzymes from some organisms utilize a dynamic equilibrium between architecturally distinct multimeric assemblies as a means for allosteric regulation." +"4.2.1.27","The reaction is effectively irreversible, favouring oxopropanoate (malonic semialdehyde) and its tautomers. Also acts on but-3-ynoate forming acetoacetate. The mechanism appears to involve hydration of the acetylene to 3-hydroxypropenoate, which will spontaneously tautomerize to 3-oxopropanoate. It is thus analogous to EC 4.1.1.78, acetylenedicarboxylate decarboxylase, in its mechanism." +"4.2.1.28","Two different forms of the enzyme have been described. One form requires a cobamide cofactor, while the other is a glycyl radical enzyme. The cobamide-dependent enzyme has been shown to also dehydrate ethylene glycol to acetaldehyde." +"4.2.1.30","Two different forms of the enzyme have been described. One form requires a cobamide cofactor, while the other is a glycyl radical enzyme." +"4.2.1.32","The enzyme exists in an inactive low-molecular-mass form, which is converted into active enzyme in the presence of Fe2+ and thiol. cf. EC 4.2.1.81 D(-)-tartrate dehydratase." +"4.2.1.33",Forms part of the leucine biosynthesis pathway. The enzyme brings about the interconversion of the two isomers of isopropylmalate. It contains an iron-sulfur cluster. +"4.2.1.34",Also hydrates fumarate to (S)-malate. +"4.2.1.35",Requires Fe2+. +"4.2.1.36","Requires a [4Fe-4S] cluster for activity. The enzyme from the hyperthermophilic eubacterium Thermus thermophilus can catalyse the reaction shown above but cannot catalyse the previously described reaction, i.e. formation of (R)-homocitrate by hydration of cis-homoaconitate. The enzyme responsible for the conversion of cis-homoaconitate into (R)-homocitrate in T. thermophilus is unknown at present but the reaction can be catalysed in vitro using aconitate hydratase from pig (EC 4.2.1.3) [2]." +"4.2.1.39","The enzyme shows no activity with D-galactonate [2]. cf. EC 4.2.1.140, gluconate/galactonate dehydratase. " +"4.2.1.42","The enzyme from the bacterium Escherichia coli is specific for galactarate [2], while the enzyme from Salmonella typhimurium also has activity with L-talarate (cf. EC 4.2.1.156, L-talarate dehydratase) [3]. cf. EC 4.2.1.158, galactarate dehydratase (D-threo-forming)." +"4.2.1.44",Requires Co2+ or Mn2+. +"4.2.1.45",Requires bound NAD+. +"4.2.1.46",Requires bound NAD+. +"4.2.1.47","The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-beta-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase [5]. Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues [6]." +"4.2.1.48",Also acts on various derivatives of D-glutamate. +"4.2.1.49",Contains tightly bound NAD+. +"4.2.1.50",A pyridoxal-phosphate protein. +"4.2.1.51","This enzyme in the enteric bacteria also possesses chorismate mutase (EC 5.4.99.5) activity, and converts chorismate into prephenate." +"4.2.1.53",Acts on a number of 10-hydroxy acids. +"4.2.1.54",A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway). +"4.2.1.55",Also acts on crotonoyl thioesters of pantetheine and acyl-carrier protein. +"4.2.1.57",Also acts on dimethylacryloyl-CoA and farnesoyl-CoA. +"4.2.1.58",Is specific for short chain-length 3-hydroxyacyl-[acyl-carrier protein] derivatives (C4 to C8). +"4.2.1.134","This is the third component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase." +"4.2.1.152","Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase." +"4.2.1.59","This enzyme is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The enzyme uses fatty acyl thioesters of ACP in vivo. Different forms of the enzyme may have preferences for substrates with different chain length. For example, the activity of FabZ, the ubiquitous enzyme in bacteria, decreases with increasing chain length. Gram-negative bacteria that produce unsaturated fatty acids, such as Escherichia coli, have another form (FabA) that prefers intermediate chain length, and also catalyses EC 5.3.3.14, trans-2-decenoyl-[acyl-carrier protein] isomerase. Despite the differences both forms can catalyse all steps leading to the synthesis of palmitate (C16:0). FabZ, but not FabA, can also accept unsaturated substrates [4]." +"4.2.1.60",Specific for C10 chain length. +"4.2.1.61","The enzyme is specific for 3-hydroxyacyl-[acyl-carrier protein] derivatives (C12 to C16), and has the highest activity on the C16 derivative." +"4.2.1.67",Also acts on L-arabinonate. +"4.2.1.68","Also acts, slowly, on D-arabinonate." +"4.2.1.70",The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo [5]. +"4.2.1.73","The product is converted non-enzymically to erythroaphin, an aphid pigment." +"4.2.1.74","Acts in the reverse direction. The best substrate for the porcine enzyme is oct-2-enoyl-CoA. Unlike EC 4.2.1.17 enoyl-CoA hydratase, it does not act on crotonoyl-CoA." +"4.2.1.75","In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen III from porphobilinogen." +"4.2.1.77",Highly specific. +"4.2.1.78","The reaction makes a six-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates. The product is the precursor of the benzylisoquinoline alkaloids in plants. The enzyme, formerly known as (S)-norlaudanosoline synthase, will also catalyse the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants." +"4.2.1.79","The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate [2]. The enzyme can also use cis-aconitate as a substrate but more slowly [2]. Both this enzyme and EC 4.2.1.3, aconitate hydratase, are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate [2]." +"4.2.1.80","The enzyme is involved in the catechol meta-cleavage pathway, a major mechanism for degradation of aromatic compounds. Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer. The enzyme was named when it was thought that the substrate is 2-oxopent-4-enoate. However, it was later found that the actual substrate is its tautomer (2Z)-2-hydroxypenta-2,4-dienoate. In some organisms the enzyme forms a complex with EC 4.1.1.77, 2-oxo-3-hexenedioate decarboxylase (previously named 4-oxalocrotonate decarboxylase)." +"4.2.1.81",Requires Fe2+ or Mn2+. cf. EC 4.2.1.32 L(+)-tartrate dehydratase. +"4.2.1.83","This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), syringate and 3,4,5-trihydroxybenzoate, catalysing the reaction in the opposite direction [1-3]. It accepts the enol-form of 4-oxalomesaconate, 2-hydroxy-4-carboxy-hexa-2,4-dienedioate [4]." +"4.2.1.84","Acts on short-chain aliphatic nitriles, converting them into the corresponding amides. Does not act on these amides or on aromatic nitriles. cf. EC 3.5.5.1 nitrilase." +"4.2.1.85",Requires Fe2+. Inhibited by oxygen. +"4.2.1.87","The enzyme-catalysed reaction is believed to be dehydration to an enamine, which is spontaneously hydrolysed to an aldehyde and ammonia." +"4.2.1.88","Removal of H2O from (R)-synephrine produces a 2,3-enamine, which hydrolyses to the products shown in the reaction above. The enzyme from Arthrobacter synephrinum is highly specific [1]." +"4.2.1.91","Also acts on prephenate and D-prephenyllactate. cf. EC 4.2.1.51, prephenate dehydratase." +"4.2.1.92","Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides. The product of the above reaction is unstable and is acted upon by EC 5.3.99.6, allene-oxide cyclase, to form the cyclopentenone derivative (15Z)-12-oxophyto-10,15-dienoate (OPDA), which is the first cyclic and biologically active metabolite in the jasmonate biosynthesis pathway [3]. The enzyme from many plants belongs to the CYP-74 family of P-450 monooxygenases [4]. " +"4.2.1.93","Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers, and these are interconverted by EC 5.1.99.6, NAD(P)H-hydrate epimerase, to a 60:40 ratio [4]. Hence EC 4.2.1.93 together with EC 5.1.99.6 can restore the mixture of hydrates into NAD(P)H [3,4]. The enzyme from eukaryotes has no activity with ADP, contrary to the enzyme from bacteria (cf. EC 4.2.1.136, ADP-dependent NAD(P)H-hydrate dehydratase) [4]." +"4.2.1.94","Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi." +"4.2.1.95","The enzyme from Fusarium sp. hydrates the methylbutenyl sidechain of the isoflavonoid phytoalexins, thus reducing their toxicity." +"4.2.1.96","In concert with EC 1.5.1.34, 6,7-dihydropteridine reductase, the enzyme recycles 4a-hydroxytetrahydrobiopterin back to tetrahydrobiopterin, a cosubstrate for several enzymes, including aromatic amino acid hydroxylases. The enzyme is bifunctional, and also acts as a dimerization cofactor of hepatocyte nuclear factor-1alpha (HNF-1)." +"4.2.1.97","The enzyme from Fusarium solani, which is distinct from kievitone hydratase (EC 4.2.1.95), hydrates the methylbutenyl side-chain of the isoflavonoid phytoalexin, phaseollidin." +"4.2.1.98","16alpha-Hydroxypregnenolone is also a substrate." +"4.2.1.99",The enzyme from the fungus Yarrowia lipolytica (Saccharomycopsis) does not act on isocitrate. +"4.2.1.100","Forms part of the anaerobic benzoate degradation pathway, which also includes EC 1.3.8.6 [glutaryl-CoA dehydrogenase (ETF)], EC 1.3.7.8 (benzoyl-CoA reductase) and EC 4.2.1.55 (3-hydroyxbutyryl-CoA dehydratase)." +"4.2.1.101","This is one of the activities of a bifunctional enzyme, trans-feruloyl-CoA hydratase/lyase, that converts trans-feruloyl-CoA to vanillin. The other activity is EC 4.1.2.41, vanillin synthase." +"4.2.1.103",The enzyme from Pseudomonas putida strain N19-2 can also catalyse the hydration of other isonitriles to the corresponding N-substituted formamides. The enzyme has no metal requirements. +"4.2.1.104","This enzyme, which is found in bacteria and plants, is used to decompose cyanate, which can be used as the sole source of nitrogen [6,7]. Reaction (1a) can be considered an equivalent of 'cyanate + H2O = carbamate', where the water molecule is provided by the dehydration of bicarbonate to carbon dioxide [2], and hence the enzyme is classified as a hydrolase." +"4.2.1.105",Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously. +"4.2.1.106","This enzyme, characterized from the gut bacterium Clostridium scindens (previously known as Eubacterium sp. strain VPI 12708), participates in the 7-dehydroxylation process associated with bile acid degradation." +"4.2.1.107","This enzyme forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity. The enzyme is involved in the beta-oxidation of the cholesterol side chain in the cholic-acid-biosynthesis pathway." +"4.2.2.1",The enzyme catalyses the degradation of hyaluronan by a beta-elimination reaction. Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose +"4.2.2.2","Favours pectate, the anion, over pectin, the methyl ester (which is the preferred substrate of EC 4.2.2.10, pectin lyase)." +"4.2.2.3","The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between beta-D-mannuronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to four residues, with preference for shorter products. cf. EC 4.2.2.11, guluronate-specific alginate lyase." +"4.2.2.4","Acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate, and acts slowly on hyaluronate. Formerly EC 4.2.99.6." +"4.2.2.5","Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1-3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [4]." +"4.2.2.6",Also catalyses eliminative removal of unsaturated terminal residues from oligosaccharides of D-galacturonate. +"4.2.2.8","Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages." +"4.2.2.9","The enzyme catalyses the eliminative cleavage of an unsaturated disaccharide from the reducing end of homogalacturonan (the backbone of smooth regions of pectate, also known as de-esterified pectin)." +"4.2.2.10","Favours pectin, the methyl ester, over pectate, the anion (which is the preferred substrate of EC 4.2.2.2, pectate lyase). Demethylation progressively slows its action; it can nevertheless cleave on either side of a demethylated residue if the residue at the other end of the scissile bond is methylated." +"4.2.2.11","The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between alpha-L-guluronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products. cf. EC 4.2.2.3, mannuronate-specific alginate lyase." +"4.2.2.13","The enzyme catalyses the sequential degradation of (1->4)-alpha-D-glucans from the non-reducing end with the release of 1,5-anhydro-D-fructose. Thus, for an alpha-glucan containing n (1->4)-linked glucose units, the final products are 1 glucose plus (n-1) 1,5-anhydro-D-fructose. Maltose, maltosaccharides and amylose are all completely degraded. It does not degrade (1->6)-alpha-glucosidic bonds and thus the degradation of a branched glucan, such as amylopectin or glycogen, will result in the formation of 1,5-anhydro-D-fructose plus a limit dextrin. Other enzymes involved in the anhydrofructose pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.1.111 (1,5-anhydro-D-fructose dehydratase) and EC 5.3.2.7 (ascopyrone tautomerase). " +"4.2.2.15",Also acts on N-glycolylneuraminate glycosides. cf. EC 3.2.1.18 (exo-alpha-sialidase) and EC 3.2.1.129 (endo-alpha-sialidase). +"4.2.2.16","This enzyme, like EC 4.2.2.17 [inulin fructotransferase (DFA-I-forming)] and EC 4.2.2.18 [inulin fructotransferase (DFA-III-forming)] eliminates the fructan chain from the terminal disaccharide leaving a difructose dianhydride. These enzymes have long been known as fructotransferases, so this is retained in the accepted name. Since the transfer is intramolecular, the reaction is an elimination and, hence, the enzyme is a lyase, belonging in EC 4." +"4.2.2.17","This enzyme, like EC 4.2.2.16 [levan fructotransferase (DFA-IV-forming)] and EC 4.2.2.18 [inulin fructotransferase (DFA-III-forming)] eliminates the fructan chain from the terminal disaccharide leaving a difructose dianhydride. These enzymes have long been known as fructotransferases, so this is retained in the accepted name. Since the transfer is intramolecular, the reaction is an elimination and, hence, the enzyme is a lyase, belonging in EC 4." +"4.2.2.18","This enzyme, like EC 4.2.2.16 [levan fructotransferase (DFA-IV-forming)] and EC 4.2.2.17 [inulin fructotransferase (DFA-I-forming)] eliminates the fructan chain from the terminal disaccharide leaving a difructose dianhydride. These enzymes have long been known as fructotransferases, so this is retained in the accepted name. Since the transfer is intramolecular, the reaction is an elimination and, hence, the enzyme is a lyase, belonging in EC 4." +"4.2.2.19","This is the only lyase that is known to be specific for dermatan sulfate as substrate. The minimum substrate length required for catalysis is a tetrasaccharide [2]. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1-3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [5]." +"4.2.3.1",A pyridoxal-phosphate protein. +"4.2.3.2",A pyridoxal-phosphate protein. Also acts on D(or L)-1-aminopropan-2-ol O-phosphate. +"4.2.3.3",Does not act on D-glyceraldehyde 3-phosphate. +"4.2.3.4",Requires Co2+ and bound NAD+. The hydrogen atoms on C-7 of the substrate are retained on C-2 of the product. +"4.2.3.5","Requires FMN. The reaction goes via a radical mechanism that involves reduced FMN and its semiquinone (FMNH(.)). Shikimate is numbered so that the double-bond is between C-1 and C-2, but some earlier papers numbered the ring in the reverse direction." +"4.2.3.7","Isolated from Streptomyces avermitilis. The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics. The 9si hydrogen of farnesyl diphosphate undergoes a 1,2-hydride shift where it becomes the 1alpha hydrogen of pentalenene." +"4.2.3.8",The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene. +"4.2.3.9","The initial internal cyclization produces the monocyclic intermediate germacrene A; further cyclization and methyl transfer converts the intermediate into aristolochene. While in some species germacrene A remains as an enzyme-bound intermediate, it has been shown to be a minor product of the reaction in Penicillium roqueforti [5] (see also EC 4.2.3.23, germacrene-A synthase). The enzyme from Penicillium roqueforti requires Mg2+. Mn2+ can partially substitute, at low concentrations. Aristolochene is the likely parent compound for a number of sesquiterpenes produced by filamentous fungi." +"4.2.3.10",(3R)-Linalyl diphosphate is an intermediate in the reaction +"4.2.3.11",Both cis- and trans- isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction +"4.2.3.12","Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I) [3]." +"4.2.3.13",The sesquiterpenoid (+)-delta-cadinene is an intermediate in phytoalexin biosynthesis. Mg2+ is required for activity. +"4.2.3.14",A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor. A mixture of alpha and beta-pinene is produced. +"4.2.3.15",A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor. +"4.2.3.16",A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor. +"4.2.3.17","This is the committed step in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The cyclization involves a 1,5-hydride shift. " +"4.2.3.18","Part of a bifunctional enzyme involved in the biosynthesis of abietadiene. See also EC 5.5.1.12, copalyl diphosphate synthase. Requires Mg2+." +"4.2.3.19",Part of a bifunctional enzyme involved in the biosynthesis of ent-kaurene. See also EC 5.5.1.13 (ent-copalyl diphosphate synthase) +"4.2.3.20","Forms the first step of carvone biosynthesis in caraway. The enzyme from Carum carvi (caraway) seeds requires a divalent metal ion (preferably Mn2+) for catalysis. This enzyme occurs in Citrus, Carum (caraway) and Anethum (dill); (-)-limonene, however, is made in the fir, Abies, and mint, Mentha, by EC 4.2.3.16, (4S)-limonene synthase." +"4.2.3.21",The initial internal cyclization produces the monocyclic intermediate germacrene A. +"4.2.99.18","'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under EC 3.1.25.2." +"4.3.1.2",A cobalamin protein. +"4.3.1.3","This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23 (tyrosine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [4]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [5]. This enzyme catalyses the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate [2,3]." +"4.3.1.4","In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity." +"4.3.1.5","This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase) and EC 4.3.1.5 (phenylalanine ammonia-lyase). The enzyme from dicotyledonous plants efficiently deaminates L-phenylalanine, whereas that from some monocots, including maize, and from the yeast Rhodosporidium toruloides can also deaminate L-tyrosine [3]. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. The substrate specificity of the enzyme can be switched from phenylalanine to tyrosine by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides [6]." +"4.3.1.6",The reaction has only been demonstrated in the direction of addition of ammonia. +"4.3.1.7",A cobalamin protein. +"4.3.1.9","Contains pyridoxal phosphate. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes spontaneous hydrolytic deamination to form the final product." +"4.3.1.12",Requires NAD+. The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2]. +"4.3.1.13","A pyridoxal-phosphate protein. The enzyme cleaves a carbon-oxygen bond, releasing CO2, ammonia, and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and a second ammonia molecule. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. " +"4.3.1.14",Hydroxylamine can replace ammonia as a substrate. Crotonoyl-pantetheine can replace crotonoyl-CoA but it is a poorer substrate. +"4.3.1.15",A pyridoxal phosphate enzyme. Active towards both D- and L-diaminopropanoate. D- and L-serine are poor substrates. +"4.3.1.16","A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Pseudomonas sp. T62, is highly specific, and does not accept any other stereoisomer of 3-hydroxyaspartate. Different from EC 4.3.1.20, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.27, threo-3-hydroxy-D-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Mg2+, or Ca2+." +"4.3.1.17","Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead [6]. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.13, L-serine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. This reaction is also carried out by EC 4.3.1.19, threonine ammonia-lyase, from a number of sources. " +"4.3.1.18","A pyridoxal-phosphate protein. The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme's original classification as EC 4.2.1.14, D-serine dehydratase) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also acts, slowly, on D-threonine." +"4.3.1.19","Most enzymes that catalyse this reaction are pyridoxal-phosphate-dependent, although some enzymes contain an iron-sulfur cluster instead. The reaction catalysed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.16, threonine dehydratase), followed by tautomerization to an imine form and hydrolysis of the C-N bond [3,5]. The latter reaction, which can occur spontaneously, is also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase [5]. The enzymes from a number of sources also act on L-serine, cf. EC 4.3.1.17, L-serine ammonia-lyase." +"4.3.1.20","A pyridoxal-phosphate protein. The enzyme, which was characterized from the bacterium Paracoccus denitrificans NCIMB 8944, is highly specific for the L-isomer of erythro-3-hydroxyaspartate. Different from EC 4.3.1.16, threo-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.27, threo-3-hydroxy-D-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Mg2+, and Ca2+." +"4.3.2.2",Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole. +"4.3.2.3","This microbial enzyme is involved in the degradation of ureidoglycolate, an intermediate of purine degradation. Not to be confused with EC 3.5.1.116, ureidoglycolate amidohydrolase, which releases ammonia rather than urea." +"4.3.2.4","Also acts on 2,6-diamino-5-formamido-3,4-dihydro-4-oxopyrimidine residues. Brings about the reclosure of the imidazole rings of purine residues damaged by gamma-rays." +"4.3.2.5","Requires zinc. The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide. In mammals, the two activities are part of a bifunctional protein." +"4.3.3.1","Requires Ca2+. Eliminates 4-nitroaniline from 4-nitrophenyl-3-ketovalidamine, or 4-nitrophenol from 4-nitrophenyl-alpha-D-3-dehydroglucoside. Involved in the degradation of the fungicide validamycin A by Flavobacterium saccharophilum." +"4.3.3.2","Catalyses a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine [4,5]. Involved in the biosynthesis of the monoterpenoid indole alkaloids." +"4.3.3.3",The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 4.3.3.4 deacetylipecoside synthase. The product is rapidly converted to demethylisoalangiside. +"4.3.3.4",The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 4.3.3.3 deacetylisoipecoside synthase. The product is rapidly converted to demethylalangiside. +"4.4.1.1","A multifunctional pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses the conversion of L-homoserine to 2-oxobutanoate and ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of L-cysteine to pyruvate, hydrogen sulfide and ammonia." +"4.4.1.2","A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogen sulfide and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase" +"4.4.1.4",A pyridoxal-phosphate protein. +"4.4.1.5",Also acts on 3-phosphoglycerol-glutathione. +"4.4.1.6","A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing an alkyl thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Possibly identical, in yeast, with EC 4.4.1.8 cystathionine beta-lyase." +"4.4.1.8","A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-homocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds. " +"5.6.1.1","A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome." +"4.4.1.9",Contains pyridoxal phospate. +"4.4.1.10","A pyridoxal-phosphate protein. Can use a second molecule of cysteine (producing lanthionine), or other alkyl thiols, as a replacing agent." +"4.4.1.11","A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing methanethiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme is involved in L-methionine catabolism." +"4.4.1.13","A pyridoxal-phosphate protein. The enzyme is promiscuous regarding the moiety conjugated to L-cysteine, and can accept both aliphatic and aromatic substitutions. The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. While bacteria and plants have dedicated enzymes, all of the animal enzymes discovered thus far are bifunctional, most of which also act as aminotransferases." +"4.4.1.14","A pyridoxal 5'-phosphate protein. The enzyme catalyses an alpha,gamma-elimination." +"4.4.1.16","A pyridoxal-phosphate protein. Dithiothreitol or 2-sulfanylethan-1-ol (2-mercaptoethanol) can act as the reducing agent in the reaction. The enzyme from animals does not act on cysteine, serine or chloroalanine [1,3], while the enzyme from bacteria shows activity with cysteine (cf. EC 2.8.1.7, cysteine desulfurase) [2]." +"4.4.1.17","In the reverse direction, the enzyme catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links." +"4.4.1.19",Requires Mg2+. The enzyme from the archaeon Methanococcus jannaschii catalyses the Michael addition of sulfite to phosphoenolpyruvate. It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite. +"4.4.1.20","The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase." +"4.4.1.21","Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density [2]." +"4.4.1.22","The enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway." +"4.4.1.23","Requires zinc. Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts. The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile. Uses short-chain epoxyalkanes from C2 (epoxyethane) to C6 (1,2-epoxyhexane). This enzyme forms component I of a four-component enzyme system (comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2." +"4.5.1.2","A pyridoxal-phosphate protein. The enzyme cleaves a carbon-chlorine bond, releasing a chloride and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme's activity can also result in beta-replacement reactions, e.g. in the presence of hydrogen sulfide it can convert 3-chloro-D-alanine into D-cysteine and chloride." +"4.5.1.3",Requires glutathione. +"4.5.1.5",A pyridoxal-phosphate protein. +"4.6.1.1","Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase." +"4.6.1.2",Also acts on ITP and dGTP. +"4.6.1.6","In bacteria and archaea the enzyme's product, cCMP, functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response." +"4.6.1.12","The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here)." +"4.6.1.13","This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11, phosphoinositide phospholipase C." +"4.6.1.14","This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors. In some cases, the long-chain acyl group at the sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group. In other cases, the diacylglycerol is replaced by ceramide (see Lip-1.4 and Lip-1.5 for definition). The only characterized enzyme with this specificity is from Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown. Substitution on O-2 of the inositol blocks action of this enzyme. It is not identical with EC 3.1.4.50, glycosylphosphatidylinositol phospholipase D." +"4.6.1.15","Requires Mn2+ or Co2+. While FAD was the best substrate tested [2], the enzyme also splits ribonucleoside diphosphate-X compounds in which X is an acyclic or cyclic monosaccharide or derivative bearing an X-OH group that is able to attack internally the proximal phosphorus with the geometry necessary to form a P=X product; either a five-atom monocyclic phosphodiester or a cis-bicyclic phosphodiester-pyranose fusion. The reaction is strongly inhibited by ADP or ATP but is unaffected by the presence of the product, cFMN." +"4.99.1.1",The enzyme catalyses the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria. +"4.99.1.2","Acts on CH3Hg+ and a number of other alkylmercury compounds, in the presence of cysteine or other thiols, liberating mercury as a mercaptide. " +"4.99.1.3","This enzyme, which forms part of the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway, is an ATP-independent type II chelatase. Two distinct forms are known - a primordial form named CbiX, which is most common in archaea, and a strictly bacterial form named CbiK. See EC 6.6.1.2, cobaltochelatase, for the cobaltochelatase that participates in the aerobic cobalamin biosynthesis pathway." +"4.99.1.4","This enzyme catalyses the third of three steps leading to the formation of siroheme from uroporphyrinogen III. The first step involves the donation of two S-adenosyl-L-methionine-derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107, uroporphyrin-III C-methyltransferase) and the second step involves an NAD+-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76, precorrin-2 dehydrogenase). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalysed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction." +"4.99.1.5","The enzyme from Pseudomonas chlororaphis contains Ca2+ and protoheme IX, the iron of which must be in the form Fe(II) for activity. The enzyme exhibits a strong preference for aliphatic aldoximes, such as butyraldoxime and acetaldoxime, over aromatic aldoximes, such as pyridine-2-aldoxime, which is a poor substrate. No activity was found with the aromatic aldoximes benzaldoxime and pyridine-4-aldoxime." +"4.99.1.7","The enzyme from Bacillus sp. OxB-1 contains protoheme IX, the iron of which must be in the form iron(II) for activity. (Z)-Phenylacetaldoxime binds to ferric heme (the iron(III) form) via the oxygen atom whereas it binds to the active ferrous form via the nitrogen atom. In this way, the oxidation state of the heme controls the coordination stucture of the substrate---heme complex, which regulates enzyme activity [2]. The enzyme is active towards several (Z)-arylacetaldoximes and (E/Z)-alkylaldoximes as well as towards arylalkylaldoximes such as 3-phenylpropionaldoxime and 4-phenylbutyraldoxime. However, it is inactive with phenylacetaldoximes that have a substituent group at an alpha-site of an oxime group, for example, with (E/Z)-2-phenylpropionaldoxime and (E/Z)-mandelaldoxime. The activity of the enzyme is inhibited completely by the heavy-metal cations Cu+, Cu2+, Ag+ and Hg+ whereas Fe2+ and Sn2+ have an activatory effect." +"5.1.1.1",A pyridoxal-phosphate protein. +"5.1.1.2",A pyridoxal-phosphate protein. +"5.1.1.3",A pyridoxal-phosphate protein. +"5.1.1.5",The enzyme is involved in a lysine catabolic pathway. +"5.1.1.6",Inverts both chiral centres. +"5.1.1.8",Also interconverts trans-4-hydroxy-D-proline and cis-4-hydroxy-L-proline. +"5.1.1.9",A pyridoxal-phosphate protein. +"5.1.1.10",A pyridoxal-phosphate protein. +"5.1.1.13","Also acts, at half the rate, on L-alanine." +"5.1.1.14","Requires pyridoxal 5'-phosphate. The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A. It catalyses the epimerization of the amino group at position 9' from (S)- configuration to (R)-. The enzyme can act on both isonocardicin A and isonocardicin C, but the in vivo substrate appears to be the latter [3]." +"5.1.1.15",Contains pyridoxal 5'-phosphate. Also racemises 2-aminopentano-5-lactam (alpha-amino-delta-valerolactam) and 2-amino-4-thiahexano-6-lactam (where S replaces CH2 of C-4). It does not catalyse the racemisation of alpha-amino acids but has some transaminase activity with them. +"5.1.1.16","The enzyme specifically interconverts the configuration of Ser-46 of the peptide omega-agatoxin-KT, found in the venom of the funnel web spider, Agelenopsis aperta, but not that of the other serine residue, Ser-28." +"5.1.1.17","This enzyme contains pyridoxal phosphate. Epimerization at C-5 of the 5-amino-5-carboxypentanoyl group to form penicillin N is required to make a substrate for EC 1.14.20.1, deactoxycephalosporin-C synthase, to produce cephalosporins. Forms part of the penicillin biosynthesis pathway (for pathway, click here)." +"5.1.2.1","The enzyme has been characterized from the bacterium Lactobacillus plantarum and appears to be restricted to lactic acid bacteria. It contains a unique nickel-containing cofactor, pyridinium-3-thioamide-5-thiocarboxylate mononucleotide Ni pincer complex." +"5.1.2.6","(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate is the commonly occurring isomer of isocitrate." +"5.1.3.1",The enzyme also converts D-erythrose 4-phosphate into D-erythrulose 4-phosphate and D-threose 4-phosphate. +"5.1.3.2",Requires NAD+. Also acts on UDP-2-deoxyglucose. +"5.1.3.3","Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. This enzyme catalyses the first step in galactose metabolism by converting beta-D-galactose into alpha-D-galactose, which is the substrate for EC 2.7.1.6, galactokinase [5,6]. " +"5.1.3.4",Requires a divalent cation for activity. +"5.1.3.8",Requires catalytic amounts of ATP. +"5.1.3.9",The enzyme found in bacteria accepts N-acetyl and N-glycoloyl derivatives [1]. +"5.1.3.10",Requires NAD+. +"5.1.3.11","The enzyme catalyses the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety." +"5.1.3.12",Requires NAD+. +"5.1.3.13",The enzyme occurs in a complex with EC 1.1.1.133 dTDP-4-dehydrorhamnose reductase. +"5.1.3.14","This bacterial enzyme catalyses the reversible interconversion of UDP-GlcNAc and UDP-ManNAc. The latter is used in a variety of bacterial polysaccharide biosyntheses. +cf. EC 3.2.1.183, UDP-N-acetylglucosamine 2-epimerase (hydrolysing)." +"5.1.3.17","The enzyme acts on D-glucosyluronate residues in N-sulfated heparosan polymers, converting them to L-iduronate, thus modifying the polymer to heparan-N-sulfate. The enzyme requires that at least the N-acetylglucosamine residue linked to C-4 of the substrate has been deacetylated and N-sulfated, and activity is highest with fully N-sulfated substrate. It does not act on glucuronate residues that are O-sulfated or are adjacent to N-acetylglucosamine residues that are O-sulfated at the 6 position. Thus the epimerization from D-glucuronate to L-iduronate occurs after N-sulfation of glucosamine residues but before O-sulfation. Not identical with EC 5.1.3.19 chondroitin-glucuronate 5-epimerase or with EC 5.1.3.36, heparosan-glucuronate 5-epimerase." +"5.1.3.18","The enzyme catalyses the formation of the stable intermediate GDP-beta-L-gulose as well as GDP-beta-L-galactose. The reaction proceeds by C4' oxidation of GDP-alpha-D-mannose followed by epimerization of the C5' position to give GDP-beta-L-4-dehydro-gulose. This intermediate is either reduced to give GDP-beta-L-gulose or the C3' position is epimerized to give GDP-beta-L-4-dehydro-galactose, followed by C4' reduction to yield GDP-beta-L-galactose. Both products serve as intermediates in two different variants of plant L-ascorbate biosynthesis pathways." +"5.1.3.19",Not identical with EC 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase. +"5.1.3.20",Requires NAD+. +"5.1.3.21",The enzyme catalyses the interconversion of alpha and beta anomers of maltose more effectively than those of disaccharides such as lactose and cellobiose. +"5.1.3.22","Along with EC 4.1.1.85, 3-dehydro-L-gulonate-6-phosphate decarboxylase, this enzyme is involved in a pathway for the utilization of L-ascorbate by Escherichia coli." +"5.1.99.4","alpha-methyl-branched acyl-CoA derivatives with chain lengths of more than C10 are substrates. Also active towards some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA. Not active towards free acids" +"5.2.1.2",Also acts on maleylpyruvate. +"5.2.1.3",Light shifts the reaction towards the cis-isomer. +"5.2.1.6",Requires NADH. +"5.2.1.7","Converts all-trans-retinol to 11-cis-retinol in the dark, thus reversing the effect of EC 5.2.1.3 retinal isomerase." +"5.2.1.8","The first type of this enzyme found [1] proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively." +"5.3.1.3","Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+). The enzyme binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism [3]. The enzyme catalyses the aldose-ketose isomerization of several sugars. Most enzymes also catalyse the reaction of EC 5.3.1.25, L-fucose isomerase [3]. The enzyme from the bacterium Falsibacillus pallidus also converts D-altrose to D-psicose [4]. cf. EC 5.3.1.4, L-arabinose isomerase." +"5.3.1.4","Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+) [2]. The enzyme binds beta-L-arabinopyranose [4] and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism [6]. The enzyme can also convert alpha-D-galactose to D-tagatose with lower efficiency [5]." +"5.3.1.5","Contains two divalent metal ions, preferably magnesium, located at different metal-binding sites within the active site. The enzyme catalyses the interconversion of aldose and ketose sugars with broad substrate specificity. The enzyme binds the closed form of its sugar substrate (in the case of xylose and glucose, only the alpha anomer [4]) and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. Isomerization proceeds via a hydride-shift mechanism." +"5.3.1.6",Also acts on D-ribose 5-diphosphate and D-ribose 5-triphosphate. +"5.3.1.7",Also acts on D-lyxose and D-rhamnose. +"5.3.1.8",A zinc protein. +"5.3.1.9",The enzyme from yeast catalyses the reversible conversion specifically between the alpha-D-glucose 6-phosphate and beta-D-fructofuranose 6-phosphate. The enzyme also catalyses the anomerization of both D-hexose 6-phosphates [7]. +"5.3.1.12",Also converts D-galacturonate to D-tagaturonate. +"5.3.1.13","The enzyme is involved in the pathway for synthesis of 3-deoxy-D-manno-octulosonate (Kdo), a component of bacterial lipopolysaccharides and plant call walls." +"5.3.1.14","Contains two divalent metal ions located at different metal-binding sites within the active site. The enzyme binds the closed ring form of the substrate and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. Isomerization proceeds via a hydride-shift mechanism. While the enzyme from the bacterium Escherichia coli is specific for L-rhamnose, the enzyme from the bacterium Pseudomonas stutzeri has broad substrate specificity and catalyses the interconversion of L-mannose and L-fructose, L-lyxose and L-xylulose, D-ribose and D-ribulose, and D-allose and D-psicose [2]." +"5.3.1.16",Involved in histidine biosynthesis. +"5.3.1.17","The enzyme is involved in the degradation of polygalacturonate, a later stage in the degradation of pectin by many microorganisms." +"5.3.1.20",Also acts on L-lyxose and L-rhamnose. +"5.3.1.21",An epimerization at C-20 and C-21 is probably catalysed by the same enzyme. +"5.3.1.24","In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.1.3.27 (anthranilate synthase) and EC 4.2.1.20 (tryptophan synthase)]." +"5.3.1.25","Requires a divalent metal ion (the enzyme from the bacterium Escherichia coli prefers Mn2+). The enzyme binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism [3]. The enzyme from Escherichia coli can also convert D-arabinose to D-ribulose [1]. The enzyme from the thermophilic bacterium Caldicellulosiruptor saccharolyticus also converts D-altrose to D-psicose and L-galactose to L-tagatose [4]." +"5.3.1.26",Involved in the tagatose 6-phosphate pathway of lactose catabolism in bacteria. +"5.3.2.1",Also acts on other arylpyruvates. +"5.3.3.1","This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase)." +"5.3.3.2","The enzyme from Streptomyces sp. strain CL190 requires FMN and NAD(P)H as cofactors. Activity is reduced if FMN is replaced by FAD, but the enzyme becomes inactive when NAD(P)H is replaced by NAD+ or NADP+. That enzyme also requires Mg2+, Mn2+ or Ca2+ for activity." +"5.3.3.3",Also acts on 3-methyl-vinylacetyl-CoA. +"5.3.3.7","cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. This isomerization could take place either in a direct cis-trans interconversion or by an allylic rearrangement; the enzyme has been shown to catalyse the latter change." +"5.3.3.8","The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position. Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C3, which cannot be processed further by the regular enzymes of the beta-oxidation system. This enzyme isomerizes the bond to a trans bond at position C2, which can be processed further. The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers. The enzyme can also catalyse the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters." +"5.3.3.9",Interconverts prostaglandin A1 and prostaglandin C1. +"5.3.3.10",Part of the homoprotocatechuate degradation pathway in Escherichia coli C. +"5.3.3.11",Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves. +"5.3.3.12","A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase)." +"5.3.3.13","The enzyme from the red alga Ptilota filicina catalyses the isomerization of skip dienes (methylene-interrupted double bonds) in a broad range of fatty acids and fatty-acid analogues, such as arachidonate and gamma-linolenate, to yield a conjugated triene." +"5.3.4.1",Needs reducing agents or partly reduced enzyme; the reaction depends on sulfhydryl-disulfide interchange. +"5.3.99.2",Brings about the opening of the epidioxy bridge. Some enzymes require glutathione. +"5.3.99.3",Brings about the opening of the epidioxy bridge. Requires glutathione. +"5.3.99.4",A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin). +"5.3.99.5",A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2. +"5.3.99.6","Allene oxides formed by the action of EC 4.2.1.92 hydroperoxide dehydratase, are converted into cyclopentenone derivatives." +"5.3.99.7",Highly specific. +"5.3.99.8",This multifunctional enzyme is induced during chromoplast differentiation in plants [1]. Isomerization of the epoxide ring of violaxanthin gives the cyclopentyl-ketone of capsorubin or capsanthin. +"5.3.99.9",The opening of the epoxide ring of violaxanthin generates a chiral allene. Neoxanthin is a precursor of the plant hormone abscisic acid and the last product of carotenoid synthesis in green plants [2]. +"5.4.2.1","The enzymes from mammals and from yeast are phosphorylated by (2R)-2,3-bis-phosphoglycerate, which is also an intermediate (see introduction to section EC 5.4.2). With the rabbit muscle enzyme, dissociation of bisphosphate from the enzyme is much slower than the overall isomerization. These enzymes also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase; they were formerly listed as EC 2.7.5.3. Enzymes from wheat, rice, insects and some fungi, however, have maximum activity in the absence of 2,3-bisphosphoglycerate, and were formerly listed under the present number as phosphoglycerate phosphomutase." +"5.4.2.11","The enzymes from vertebrates, platyhelminths, mollusks, annelids, crustaceans, insects, algae, some fungi and some bacteria (particularly Gram-negative) require 2,3-bisphospho-D-glycerate as a cofactor. The enzyme is activated by 2,3-bisphospho-D-glycerate by transferring a phosphate to histidine (His10 in man and Escherichia coli, His8 in Saccharomyces cerevisiae). This phosphate can be transferred to the free OH of 2-phospho-D-glycerate, followed by transfer of the phosphate already on the phosphoglycerate back to the histidine. cf. EC 5.4.2.12 phosphoglycerate mutase. The enzyme has no requirement for metal ions. This enzyme also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase." +"5.4.2.2","Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. The enzyme also catalyses (more slowly) the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. cf. EC 5.4.2.5, phosphoglucomutase (glucose-cofactor)." +"5.4.2.3","The enzyme is activated by N-acetyl-alpha-D-glucosamine 1,6-bisphosphate." +"5.4.2.4","In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. This enzyme also catalyses, slowly, the reaction of EC 5.4.2.11 [phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)] and EC 5.4.2.12 [phosphoglycerate mutase (2,3-diphosphoglycerate-independent)]." +"5.4.2.5","The enzyme is activated by D-glucose, which probably acts as an acceptor for a phosphate residue from the substrate, thus being itself converted into the product. cf. EC 5.4.2.2, phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)." +"5.4.2.6","The enzyme requires Mg2+ and phosphorylation of an aspartate residue at the active site. The enzyme is able to autophosphorylate itself with its substrate beta-D-glucose 1-phosphate. Although this is a slow reaction, only a single turnover is required for activation. Once the phosphorylated enzyme is formed, it generates the reaction intermediate beta-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles [4]. cf. EC 5.4.2.2, phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)." +"5.4.2.7","Also converts 2-deoxy-alpha-D-ribose 1-phosphate into 2-deoxy-D-ribose 5-phosphate. alpha-D-Ribose 1,5-bisphosphate, 2-deoxy-alpha-D-ribose 1,5-bisphosphate, or alpha-D-glucose 1,6-bisphosphate can act as cofactor." +"5.4.2.8","alpha-D-Mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor." +"5.4.2.9","Involved in the biosynthesis of the C-P bond, although the equilibrium greatly favours phosphoenolpyruvate." +"5.4.2.10","The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6-bisphosphate, which is an intermediate in the reaction, alpha-D-glucose 1,6-bisphosphate or ATP. It can also catalyse the interconversion of alpha-D-glucose 1-phosphate and glucose 6-phosphate, although at a much lower rate." +"5.4.3.2","This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule. Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions. A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron-sulfur cluster. S-adenosyl-L-methionine is regenerated at the end of the reaction." +"5.4.3.3","This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It requires pyridoxal 5'-phosphate and adenosylcobalamin for activity. A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of adenosylcobalamin, which is regenerated at the end of the reaction." +"5.4.3.4",Requires a cobamide coenzyme. +"5.4.3.5",A pyridoxal-phosphate protein that requires a cobamide cofactor for activity. +"5.4.3.6",Requires ATP. +"5.4.3.7",Requires a cobamide cofactor. +"5.4.3.8",Requires pyridoxal phosphate. +"5.4.4.2",Requires Mg2+. The reaction is reversible. +"5.4.99.1",Requires a cobamide cofactor. +"5.4.99.2",Requires a cobamide coenzyme. +"5.4.99.3",Requires ascorbic acid; also converts 2-aceto-2-hydroxybutanoate to 3-hydroxy-3-methyl-2-oxopentanoate. +"5.4.99.4",Requires a cobamide cofactor. +"5.4.99.9","A flavoenzyme which generates UDP-alpha-D-glactofuranose required for cell wall formation in bacteria, fungi, and protozoa." +"5.4.99.11",The enzyme simultaneously produces isomaltulose (6-O-alpha-D-glucopyranosyl-D-fructose) and smaller amounts of trehalulose (1-O-alpha-D-glucopyranosyl-beta-D-fructose) from sucrose. +"5.4.99.12","The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine. TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures [1]. " +"5.4.99.13","This bacterial enzyme utilizes 5'-deoxyadenosylcobalamin as a cofactor. Following substrate binding, the enzyme catalyses the homolytic cleavage of the cobalt-carbon bond of AdoCbl, yielding cob(II)alamin and a 5'-deoxyadenosyl radical, which initiates the the carbon skeleton rearrangement reaction by hydrogen atom abstraction from the substrate. At the end of each catalytic cycle the 5'-deoxyadenosyl radical and cob(II)alamin recombine, regenerating the resting form of the cofactor. The enzyme is prone to inactivation resulting from occassional loss of the 5'-deoxyadenosyl molecule. Inactivated enzymes are repaired by the action of EC 2.5.1.17, cob(I)yrinic acid a,c-diamide adenosyltransferase, and a G-protein chaperone, which restore cob(II)alamin (which is first reduced to cob(I)alamin by an unidentified reductase) to 5'-deoxyadenosylcobalamin and load it back on the mutase. Some mutases are fused with their G-protein chaperone. These enzyme can also catalyse the interconversion of isovaleryl-CoA with pivalyl-CoA." +"5.4.99.15","The enzyme from Arthrobacter sp., Sulfolobus acidocaldarius acts on (1->4)-alpha-D-glucans containing three or more (1->4)-alpha-linked D-glucose units. Not active towards maltose." +"5.4.99.17","The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129, squaleneβ€”hopanol cyclase). Hopene and hopanol are formed at a constant ratio of 5:1. " +"5.5.1.1","Requires Mn2+. Also acts (in the reverse reaction) on 3-methyl-cis,cis-muconate and, very slowly, on cis,trans-muconate. Not identical with EC 5.5.1.7 (chloromuconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase)." +"5.5.1.4","Requires NAD+, which dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form." +"5.5.1.7","Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts on 2-chloro-cis,cis-muconate. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase)." +"5.5.1.8",Requires Mg2+. The enzyme from Salvia officinalis (sage) can also use (3R)-linalyl diphosphate or more slowly neryl diphosphate in vitro [3]. The reaction proceeds via isomeration of geranyl diphosphate to (3R)-linalyl diphosphate. The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (+)-bornyl diphosphate [3]. cf. EC 5.5.1.22 [(-)-bornyl diphosphate synthase]. +"5.5.1.9","Opens the cyclopropane ring of a number of related 4alpha-methyl-9beta-19-cyclosterols, but not those with a 4beta-methyl group, with formation of an 8(9) double bond. Involved in the synthesis of plant sterols." +"5.5.1.10",Both rings of pinene are cleaved in the reaction. +"5.5.1.11","Requires Mn2+. The product of cycloisomerization of dichloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylene-3-chlorobut-2-en-4-olide. Also acts, in the reverse direction, on cis,cis-muconate and its monochloro-derivatives, but with lower affinity. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.7 (chloromuconate cycloisomerase)." +"5.5.1.12","In some plants, such as Salvia miltiorrhiza, this enzyme is monofunctional. In other plants this activity is often a part of a bifunctional enzyme. For example, in Selaginella moellendorffii this activity is catalysed by a bifunctional enzyme that also catalyses EC 4.2.3.131, miltiradiene synthase, while in the tree Abies grandis (grand fir) it is catalysed by a bifunctional enzyme that also catalyses EC 4.2.3.18, abietadiene synthase." +"5.5.1.13",Part of a bifunctional enzyme involved in the biosynthesis of kaurene. See also EC 4.2.3.19 (ent-kaurene synthase) +"5.99.1.2","These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.1.2.2 DNA topoisomerase (ATP-hydrolysing)." +"5.99.1.3","The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.99.1.2 DNA topoisomerase)." +"6.1.1.10","In those organisms producing N-formylmethionyl-tRNAfMet for translation initiation, this enzyme also recognizes the initiator tRNAfMet and catalyses the formation of L-methionyl-tRNAfMet, the substrate for EC 2.1.2.9, methionyl-tRNA formyltransferase." +"6.1.1.11","This enzyme also recognizes tRNASec, the special tRNA for selenocysteine, and catalyses the formation of L-seryl-tRNASec, the substrate for EC 2.9.1.1, L-seryl-tRNASec selenium transferase." +"6.1.1.13",A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4'-phosphopantetheine cofactor of D-alanyl carrier protein during the activation of the alanine. Involved in the synthesis of teichoic acids. +"6.1.1.23","When this enzyme acts on tRNAAsp, it catalyses the same reaction as EC 6.1.1.12, aspartate---tRNA ligase. It has, however, diminished discrimination, so that it can also form aspartyl-tRNAAsn. This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon [1]. This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNAAsp (GUC anticodon) and tRNAAsn (GUU anticodon). The aspartyl-tRNAAsn is not used in protein synthesis until it is converted by EC 6.3.5.6, asparaginyl-tRNA synthase (glutamine-hydrolysing), into asparaginyl-tRNAAsn." +"6.1.1.24","When this enzyme acts on tRNAGlu, it catalyses the same reaction as EC 6.1.1.17, glutamate---tRNA ligase. It has, however, diminished discrimination, so that it can also form glutamyl-tRNAGln. This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon [1]. This accounts for the ability of this enzyme in, for example, Bacillus subtilis, to recognize both tRNA1Gln (UUG anticodon) and tRNAGlu (UUC anticodon) but not tRNA2Gln (CUG anticodon). The ability of this enzyme to recognize both tRNAGlu and one of the tRNAGln isoacceptors derives from their sharing a major identity element, a hypermodified derivative of U34 (5-methylaminomethyl-2-thiouridine). The glutamyl-tRNAGln is not used in protein synthesis until it is converted by EC 6.3.5.7, glutaminyl-tRNA synthase (glutamine-hydrolysing), into glutaminyl-tRNAGln." +"6.1.1.25","In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNAPyl, with a CUA anticodon, is charged with lysine by this class II aminoacyl---tRNA ligase. The tRNA and the ligase are encoded within the same gene cluster, and the ligase does not appear to be closely related to EC 6.1.1.6, lysine---tRNA ligase." +"6.2.1.1",Also acts on propanoate and propenoate. +"6.2.1.2","Acts on fatty acids from C4 to C11 and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives." +"6.2.1.3","Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24." +"6.2.1.4","Itaconate can act instead of succinate, and ITP instead of GTP." +"6.2.1.6",GTP or ITP can act instead of ATP. +"6.2.1.7","Requires Mg2+ for activity. The mammalian enzyme is membrane-bound and catalyses the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates [7]. The bacterial enzyme is soluble and participates in an anaerobic bile acid 7 alpha-dehydroxylation pathway [5]." +"6.2.1.13","Also acts on propanoate and, very slowly, on butanoate." +"6.2.1.15","Not identical with EC 6.2.1.3 long-chain-fatty-acid---CoA ligase. Icosa-8,11,14-trienoate, but not the other long-chain fatty acids, can act in place of arachidonate." +"6.2.1.16","Also acts, more slowly, on L-3-hydroxybutanoate." +"6.2.1.17",Propenoate can act instead of propanoate. Not identical with EC 6.2.1.1 (acetate---CoA ligase) or EC 6.2.1.2 (butyrate---CoA ligase). +"6.2.1.18",The enzyme is a component of EC 2.3.3.8 ATP citrate synthase. +"6.2.1.19","Together with a hydrolase component (EC 3.1.2.2/EC 3.1.2.14) and a reductase component (EC 1.2.1.50), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3). The enzyme activates free long-chain fatty acids, generated by the action of the transferase component, forming a fatty acyl-AMP intermediate, followed by the transfer of the acyl group to an internal L-cysteine residue. It then transfers the acyl group to EC 1.2.1.50, long-chain acyl-protein thioester reductase." +"6.2.1.20",The enzyme ligates long chain fatty acids (with aliphatic chain of 13-22 carbons) to an acyl-carrier protein. Not identical with EC 6.2.1.3 long-chain-fatty-acid---CoA ligase. +"6.2.1.22","Both this enzyme and EC 2.3.1.49,deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase, acetylate and activate EC 4.1.3.6, citrate (pro-3S)-lyase." +"6.2.1.23",Acts on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid. +"6.2.1.24",Not identical with EC 6.2.1.20 long-chain-fatty-acid---[acyl-carrier-protein] ligase. +"6.2.1.25","Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates." +"6.2.1.29",Not identical with EC 6.2.1.3 (long-chain-fatty-acid---CoA ligase) or EC 6.2.1.7 (cholate---CoA ligase). +"6.2.1.30","Also acts, more slowly, on acetate, propanoate and butanoate, but not on hydroxy derivatives of phenylacetate and related compounds." +"6.2.1.33","Requires Mg2+. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway." +"6.2.1.34",Requires Mg2+. It has not yet been established whether AMP + diphosphate or ADP + phosphate are formed in this reaction. +"6.3.1.2","Glutamine synthetase, which catalyses the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. Several types have been described, differing in their oligomeric structures and cofactor requirements." +"6.3.1.5","L-Glutamine also acts, more slowly, as amido-donor [cf. EC 6.3.5.1]." +"6.3.1.7","Glutamine can act instead of NH3, but more slowly." +"6.3.1.8","Requires magnesium ions. Involved in the synthesis of trypanothione in trypanosomatids. The enzyme from Escherichia coli is bifunctional and also catalyses the glutathionylspermidine amidase (EC 3.5.1.78) reaction, resulting in a net hydrolysis of ATP." +"6.3.1.9","The enzyme, characterized from several trypanosomatids (e.g. Trypanosoma cruzi) catalyses two subsequent reactions, leading to production of trypanothione from glutathione and spermidine. Some trypanosomatids (e.g. Crithidia species and some Leishmania species) also contain an enzyme that only carries out the first reaction (cf. EC 6.3.1.8, glutathionylspermidine synthase). The enzyme is bifunctional, and also catalyses the hydrolysis of glutathionylspermidine and trypanothione (cf. EC 3.5.1.78, glutathionylspermidine amidase)." +"6.3.1.10","One of the substrates for this reaction, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81, threonine-phosphate decarboxylase)." +"6.3.1.11",Forms part of a novel bacterial putrescine utilization pathway in Escherichia coli. +"6.3.2.2",Can use L-aminohexanoate in place of glutamate. +"6.3.2.4","Involved with EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate---L-alanine ligase), EC 6.3.2.9 (UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase) and EC 6.3.2.10 (UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase) in the synthesis of a cell-wall peptide (click here for diagram)." +"6.3.2.5","A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC 6.3.2.51, which requires ATP. Cysteine can be replaced by some of its derivatives." +"6.3.2.6",Forms part of the purine biosynthesis pathway. +"6.3.2.7","Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase) adds 2,6-diaminopimelate instead." +"6.3.2.8",Involved in the synthesis of a cell-wall peptide in bacteria. +"6.3.2.9",Involved in the synthesis of a cell-wall peptide in bacteria. +"6.3.2.10","Involved with EC 6.3.2.4 (D-alanine---D-alanine ligase), EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) or EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase), EC 6.3.2.8 (UDP-N-acetylmuramate---L-alanine ligase) and EC 6.3.2.9 (UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase) in the synthesis of a cell-wall peptide (click here) for diagram. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is meso-2,6-diaminoheptanedioate (acylated at its L-centre), linking the D-Ala-D-Ala to the carboxy group of the L-centre. This activity was previously attributed to EC 6.3.2.15, which has since been deleted." +"6.3.2.11","This enzyme was thought to form AMP [1,2], but studies with highly purified enzyme proved that it forms ADP [4]. Carnosine is a dipeptide that is present at high concentrations in skeletal muscle and the olfactory bulb of vertebrates [3]. It is also found in the skeletal muscle of some invertebrates. The enzyme can also catalyse the formation of homocarnosine from 4-aminobutanoate and L-histidine, with much lower activity [4]." +"6.3.2.12","In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.17, tetrahydrofolate synthase [2], the combined activity of which leads to the formation of the cofactor polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates. In contrast, the activities are located on separate proteins in most eukaryotes studied to date [3]. This enzyme is responsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate and is present only in those organisms that have the ability to synthesize tetrahydrofolate de novo, e.g. plants, most bacteria, fungi and protozoa [3]." +"6.3.2.13",Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) adds lysine instead. It is the amino group of the L-centre of the diaminopimelate that is acylated. +"6.3.5.11","This enzyme is the first glutamine amidotransferase that participates in the anaerobic (early cobalt insertion) biosynthetic pathway of adenosylcobalamin, and catalyses the ATP-dependent synthesis of cobyrinate a,c-diamide from cobyrinate using either L-glutamine or ammonia as the nitrogen source. It is proposed that the enzyme first catalyses the amidation of the c-carboxylate, and then the intermediate is released into solution and binds to the same catalytic site for the amidation of the a-carboxylate. The Km for ammonia is substantially higher than that for L-glutamine. The equivalent reaction in the aerobic cobalamin biosynthesis pathway is catalysed by EC 6.3.5.9, hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)." +"6.3.2.14","This enzyme complex catalyses the conversion of three molecules each of 2,3-dihydroxybenzoate and L-serine to form the siderophore enterobactin. In Escherichia coli the complex is formed by EntB (an aryl carrier protein that has to be activated by 4'-phosphopantetheine), EntD (a phosphopantetheinyl transferase that activates EntB), EntE (catalyses the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB to form the covalently arylated form of EntB), and EntF (a four domain protein that catalyses the activation of L-serine by ATP, the condensation of the activated L-serine with the activated 2,3-dihydroxybenzoate, and the trimerization of three such moieties to a single enterobactin molecule)." +"6.3.2.16",Involved in the synthesis of teichoic acids. +"6.3.2.17","In some bacteria, a single protein catalyses both this activity and that of EC 6.3.2.12, dihydrofolate synthase [3], the combined activity of which leads to the formation of the cofactor polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates (H4folate). In contrast, the activities are located on separate proteins in most eukaryotes studied to date [4]. In Arabidopsis thaliana, this enzyme is present as distinct isoforms in the mitochondria, the cytosol and the chloroplast. Each isoform is encoded by a separate gene, a situation that is unique among eukaryotes [4]. As the affinity of folate-dependent enzymes increases markedly with the number of glutamic residues, the tetrahydropteroyl polyglutamates are the preferred cofactors of C1 metabolism. (reviewed in [5]). The enzymes from different sources (particularly eukaryotes versus prokaryotes) have different substrate specificities with regard to one-carbon substituents and the number of glutamate residues present on the tetrahydrofolates." +"1.1.3.49","Contains FAD. The enzyme, characterized from the millipede Chamberlinius hualienensis, is segregated from its substrate, which is contained in special sacs. The sacs are ruptured during defensive behavior, allowing the enzyme and substrate to mix in special reaction chambers leading to production of the defensive chemical benzoyl cyanide." +"6.3.2.19","Ubiquitin is coupled to protein by a peptide bond between the C-terminal glycine of ubiquitin and epsilon-amino groups of lysine residues in the protein. An intermediate in the reaction contains one ubiquitin residue bound as a thioester to the enzyme, and a residue of ubiquitin adenylate non-covalently bound to the enzyme." +"6.3.2.21",Specific for Ca2+-calmodulin from vertebrates. At least three ubiquitin molecules can be coupled to lysine residues in calmodulin. +"6.3.2.23",Not identical with EC 6.3.2.3 glutathione synthase. +"6.3.2.25","L-Tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyromega-alpha-tubulin). The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine. L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values." +"6.3.2.26","Requires Mg2+. The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction. Forms part of the penicillin biosynthesis pathway (for pathway, click here)." +"6.3.2.27","Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation [5]. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxylysine and one molecule of citric acid. This is the last of the three enzymes involved in its synthesis, the others being EC 1.14.13.59, L-lysine 6-monooxygenase (NADPH) and EC 2.3.1.102, N6-hydroxylysine O-acetyltransferase [3]." +"6.3.3.3",CTP has half the activity of ATP. +"6.3.3.4","Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. It has been proposed [3] that L-N2-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the beta-lactam ring is then formed by the intramolecular attack of the beta-nitrogen on the activated carboxy group." +"6.3.4.2","The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2, glutaminase), and the active site where CTP synthesis takes place. The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP [4,5]. Ammonia then reacts with this intermediate generating CTP and a phosphate. The enzyme can also use ammonia from the surrounding solution [3,6]." +"6.3.4.3",In eukaryotes occurs as a trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity. +"6.3.4.6","A biotinyl-protein. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 3.5.1.54 allophanate hydrolase, thus bringing about the hydrolysis of urea to CO2 and NH3. Previously also listed as EC 3.5.1.45. The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates [4]." +"6.3.4.14","This enzyme, part of an acetyl-CoA carboxylase complex, acts on a biotin carboxyl-carrier protein (BCCP) that has been biotinylated by EC 6.3.4.15, biotin---[biotin carboxyl-carrier protein] ligase. In some organisms the enzyme is part of a multi-domain polypeptide that also includes the carrier protein (e.g. mycobacteria). Yet in other organisms (e.g. mammals) this activity is included in a single polypeptide that also catalyses the transfer of the carboxyl group from biotin to acetyl-CoA (see EC 6.4.1.2, acetyl-CoA carboxylase)." +"6.3.4.15","The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14, biotin carboxylase. The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15, acetyl-CoA carboxytransferase. In some organisms the carrier protein is part of EC 6.4.1.2, acetyl-CoA carboxylase." +"6.3.4.16","The enzyme catalyses the first committed step in the urea cycle. The reaction proceeds via three separate chemical reactions: phosphorylation of hydrogencarbonate to carboxyphosphate; a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate; and the phosphorylation of carbamate forming carbamoyl phosphate. Two moles of ATP are utilized for the synthesis of one molecule of carbamyl phosphate, making the reaction essentially irreversible. The enzyme requires the allosteric activator N-acetyl-L-glutamate. cf. EC 6.3.5.5, carbamoyl-phosphate synthase (glutamine-hydrolysing)." +"6.3.4.17",Not identical with EC 6.3.4.3 (formate---tetrahydrofolate ligase). +"6.3.5.1",NH3 can act instead of glutamine (cf. EC 6.3.1.5 NAD+ synthase). +"6.3.5.2","Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia." +"6.3.5.4","The enzyme from Escherichia coli has two active sites [4] that are connected by an intramolecular ammonia tunnel [5,6]. The enzyme catalyses three distinct chemical reactions: glutamine hydrolysis to yield ammonia takes place in the N-terminal domain. The C-terminal active site mediates both the synthesis of a beta-aspartyl-AMP intermediate and its subsequent reaction with ammonia. The ammonia released is channeled to the other active site to yield asparagine [6]." +"6.3.5.5","The product carbamoyl phosphate is an intermediate in the biosynthesis of arginine and the pyrimidine nucleotides [4]. The enzyme from Escherichia coli has three separate active sites, which are connected by a molecular tunnel that is almost 100 A in length [8]. The amidotransferase domain within the small subunit of the enzyme hydrolyses glutamine to ammonia via a thioester intermediate. The ammonia migrates through the interior of the protein, where it reacts with carboxyphosphate to produce the carbamate intermediate. The carboxyphosphate intermediate is formed by the phosphorylation of hydrogencarbonate by ATP at a site contained within the N-terminal half of the large subunit. The carbamate intermediate is transported through the interior of the protein to a second site within the C-terminal half of the large subunit, where it is phosphorylated by another ATP to yield the final product, carbamoyl phosphate [6]. cf. EC 6.3.4.16, carbamoyl-phosphate synthase (ammonia)." +"6.3.5.6","This reaction forms part of a two-reaction system for producing asparaginyl-tRNA in Deinococcus radiodurans and other organisms lacking a specific enzyme for asparagine synthesis. In the first step, a non-discriminating ligase (EC 6.1.1.23, aspartate---tRNAAsn ligase) mischarges tRNAAsn with aspartate, leading to the formation of aspartyl-tRNAAsn. The aspartyl-tRNAAsn is not used in protein synthesis until the present enzyme converts it into asparaginyl-tRNAAsn (aspartyl-tRNAAsp is not a substrate for this enzyme). A glutaminase subunit (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is transferred by a 30 A tunnel to a synthase subunit, where it is ligated to the carboxy group that has been activated by phosphorylation. Bacterial GatCAB complexes also has the activity of EC 6.3.5.7 [glutaminyl-tRNA synthase (glutamine-hydrolysing)]. " +"6.3.5.7","In systems lacking discernible glutamine---tRNA ligase (EC 6.1.1.18), glutaminyl-tRNAGln is formed by a two-enzyme system. In the first step, a nondiscriminating ligase (EC 6.1.1.24, glutamate---tRNAGln ligase) mischarges tRNAGln with glutamate, forming glutamyl-tRNAGln. The glutamyl-tRNAGln is not used in protein synthesis until the present enzyme converts it into glutaminyl-tRNAGln (glutamyl-tRNAGlu is not a substrate for this enzyme). A glutaminase subunit (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is transferred by a 30 A tunnel to a synthase subunit, where it is ligated to the carboxy group that has been activated by phosphorylation. Some bacterial GatCAB complexes also has the activity of EC 6.3.5.6 [asparaginyl-tRNA synthase (glutamine-hydrolysing)]. " +"6.3.5.8","The enzyme is composed of two parts, PabA and PabB. In the absence of PabA and glutamine, PabB converts ammonia and chorismate into 4-amino-4-deoxychorismate (in the presence of Mg2+). PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form p-aminobenzoate." +"6.3.5.9","This enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, generates hydrogenobyrinate a,c-diamide, the substrate required by EC 6.6.1.2, cobaltochelatase, which adds cobalt to the macrocycle. The equivalent reaction in the anaerobic cobalamin biosynthesis pathway is catalysed by EC 6.3.5.11, cobyrinate a,c-diamide synthase." +"6.3.5.10","Requires Mg2+. NH3 can act instead of glutamine. This enzyme catalyses the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates." +"6.4.1.1",A biotinyl-protein containing manganese (animal tissues) or zinc (yeast). The animal enzyme requires acetyl-CoA. +"6.4.1.2","This enzyme is a multi-domain polypeptide that catalyses three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyses the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA. In some organisms these activities are catalysed by separate enzymes (see EC 6.3.4.14, biotin carboxylase, and EC 2.1.3.15, acetyl-CoA carboxytransferase). The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not." +"6.4.1.3",A biotinyl-protein. Also carboxylates butanoyl-CoA and catalyses transcarboxylation. +"6.4.1.4",A biotinyl-protein. +"6.4.1.5",A biotinyl-protein. Also carboxylates dimethylpropenoyl-CoA and farnesoyl-CoA. +"6.4.1.6","Requires Mg2+ and ATP. The reaction involves separate phosphorylation of hydrogencarbonate and acetone, forming carboxyphosphate and phosphoenolacetone, respectively, which are combined to form the final product. The enzyme from Xanthobacter sp. strain Py2 also carboxylates butan-2-one to 3-oxopentanoate." +"6.5.1.1","The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. RNA can also act as substrate, to some extent. cf. EC 6.5.1.2, DNA ligase (NAD+), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP)." +"6.5.1.2","The enzyme, typically found in bacteria, catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by NAD+, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. RNA can also act as substrate, to some extent. cf. EC 6.5.1.1, DNA ligase (ATP), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP)." +"6.5.1.3","The enzyme catalyses the ligation of RNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in RNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[RNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. " +"6.5.1.4","The enzyme converts the 3'-terminal phosphate of various RNA substrates into the 2',3'-cyclic phosphodiester in an ATP-dependent reaction. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a histidine residue [5,6]. The adenylate group is then transferred to the 3'-phosphate terminus of the substrate, forming the capped structure [RNA]-3'-(5'-diphosphoadenosine). Finally, the enzyme catalyses an attack of the vicinal O-2' on the 3'-phosphorus, which results in formation of cyclic phosphate and release of the adenylate. The enzyme also has a polynucleotide 5' adenylylation activity [7]. cf. EC 6.5.1.5, RNA 3'-terminal-phosphate cyclase (GTP)." +"6.6.1.1",This is the first committed step of chlorophyll biosynthesis and is a branchpoint of two major routes in the tetrapyrrole pathway. +"6.6.1.2","This enzyme, which forms part of the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP-dependent. It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST [1]. Hydrogenobyrinate is a very poor substrate. ATP can be replaced by dATP or CTP but the reaction proceeds more slowly. CobN exhibits a high affinity for hydrogenobyrinate a,c-diamide. The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding. See EC 4.99.1.3, sirohydrochlorin cobaltochelatase, for the cobaltochelatase that participates in the anaerobic cobalamin biosynthesis pathway." +"1.1.3.2",Contains flavin mononucleotide (FMN). The best characterized enzyme is that from the bacterium Aerococcus viridans. The enzyme is widely used in biosensors to measure the lactate concentration in blood and other tissues. +"2.7.11.3","The enzyme is activated by AMP and is specific for its substrate. Phosphorylates and activates EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, that has been inactivated by EC 3.1.3.16, protein-serine/threonine phosphatase." +"2.7.10.1","The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies." +"2.7.10.2","Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1]." +"2.7.11.1",This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date. +"2.7.11.2","The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring)." +"2.7.11.4","The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)." +"2.7.11.5","The enzyme has no activating compound but is specific for its substrate. Phosphorylates and inactivates EC 1.1.1.42, isocitrate dehydrogenase (NADP+)." +"2.7.11.6","The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation." +"2.7.11.7","The enzyme from Dictyostelium sp. (slime moulds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. One threonine residue in each heavy chain acts as acceptor. While the enzyme from some species is activated by actin, in other cases Ca2+/calmodulin are required for activity." +"2.7.11.8","This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation." +"2.7.11.9","This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease." +"2.7.11.10","The enzyme phosphorylates IkappaB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-kappaB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably." +"2.7.11.11","This eukaryotic enzyme recognizes the sequence -Arg-Arg-X-Ser*/Thr*-Hpo, where * indicates the phosphorylated residue and Hpo indicates a hydrophobic residue.The inactive holoenzyme is a heterotetramer composed of two regulatory (R) subunits and two catalytic (C) subunits. Each R subunit occludes the active site of a C subunit and contains two binding sites for 3',5'-cyclic-AMP (cAMP). Binding of cAMP activates the enzyme by causing conformational changes that release two free monomeric C subunits from a dimer of the R subunits, i.e. R2C2 + 4 cAMP = R2(cAMP)4 + 2 C. Activity requires phosphorylation of a conserved Thr in the activation loop (T-loop) sequence (Thr198 in human Calpha; Thr224 in budding yeast Tpk2), installed by auto-phosphorylation or by the 3-phosphoinositide-dependent protein kinase-1 (PDPK1). Certain R2C2 combinations can be localized to particular subcellular regions by their association with diverse species of 'A Kinase-Anchoring Proteins' (AKAPs). The enzyme has been characterized from many organisms. Humans have three C units (Calpha, Cbeta, and Cgamma) encoded by the paralogous genes PRKACA, PRKACB and PRKACG, respectively, and four R subunits (R1alpha, RIbeta, RIIalpha and RIIbeta), encoded by PKRAR1A, PKRAR1B, PKRAR2A and PKRAR2B, respectively. Yeast (Saccharomyces cerevisiae) has three C subunits (Tpk1, Tpk2, and Tpk3) encoded by the paralogous genes TPK1, TPK2 and TPK3, respectively, and a single R subunit (Bcy1) encoded by the BCY1 gene. Some validated substrates of the enzyme include cAMP-response element-binding protein (CREB), phosphorylase kinase alpha subunit (PHKA), and tyrosine 3-monooxygenase (TH) in mammals; Adr1, Whi3, Nej1, and Pyk1 in yeast." +"2.7.11.12",CGMP is required to activate this enzyme. The enzyme occurs as a dimer in higher eukaryotes. The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. This domain catalyses the phosphorylation by ATP to specific serine or threonine residues in protein substrates [3]. The enzyme also has two allosteric cGMP-binding sites (sites A and B). Binding of cGMP causes a conformational change that is associated with activation of the kinase [4]. +"2.7.11.13","A family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol. Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell-signalling pathways. Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumour promoters." +"2.7.11.14","Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the bleached or activated form of rhodopsin; also phosphorylates the beta-adrenergic receptor, but more slowly. Does not act on casein, histones or phosphvitin. Inhibited by Zn2+ and digitonin (cf. EC 2.7.11.15, beta-adrenergic-receptor kinase and EC 2.7.11.16, G-protein-coupled receptor kinase)." +"2.7.11.15","Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase)." +"2.7.11.16","Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, beta-adrenergic-receptor kinase)." +"2.7.11.17","Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase)." +"2.7.11.18","Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly." +"2.7.11.19","Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b [5]. The gamma subunit of the tetrameric enzyme is the catalytic subunit." +"2.7.11.20","Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2]." +"2.7.11.21","The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2]." +"2.7.11.22","Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation." +"2.7.11.23","The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone." +"2.7.11.24","Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury." +"2.7.11.25","This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury." +"2.7.11.26","Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease." +"2.7.11.27","Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form [5]. Phosphorylates serine residues." +"2.7.11.28","The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein." +"2.7.11.29",Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP. +"2.7.11.30","The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3]." +"2.7.11.31","The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) [5]. Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP [4]" +"2.7.13.1",A number of histones can act as acceptor. +"2.7.13.2",A number of histones can act as acceptor. +"2.7.13.3",This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor. +"2.7.99.1",This enzyme was originally thought to use diphosphate as substrate [1] but this has since been disproved [2]. The activity is observed as the second part of a biphasic reaction after depletion of ATP. Tripolyphosphate is a contaminant of [gamma-32P]ATP. +"2.7.12.1",This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. +"2.7.12.2","This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury." +"1.1.1.289","The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family." +"1.1.1.290","This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid [6]. cf. EC 1.1.1.399, 2-oxoglutarate reductase." +"1.2.1.71","This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6]." +"1.2.1.72","This enzyme was originally thought to be a glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12), but this has since been disproved, as glyceraldehyde 3-phosphate is not a substrate [1,2]. Forms part of the pyridoxal-5'-phosphate cofactor biosynthesis pathway in Escherichia coli, along with EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (pyridoxamine-phosphate oxidase). " +"1.7.1.13","The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queuosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, tRNA-guanosine34 transglycosylase. Queuosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria [2] and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies." +"5.2.1.12","The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b." +"1.11.1.16","A hemoprotein. This ligninolytic peroxidase combines the substrate-specificity characteristics of the two other ligninolytic peroxidases, EC 1.11.1.13, manganese peroxidase and EC 1.11.1.14, lignin peroxidase. Unlike these two enzymes, it is also able to oxidize phenols, hydroquinones and both low- and high-redox-potential dyes, due to a hybrid molecular architecture that involves multiple binding sites for substrates [2,4]." +"1.13.11.52","A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase [1]. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver [2]. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan [2,6]. Superoxide radicals can replace O2 as oxygen donor [4,7]." +"1.13.11.53","Requires Ni2+. If iron(II) is bound instead of Ni2+, the reaction catalysed by EC 1.13.11.54, acireductone dioxygenase [iron(II)-requiring], occurs instead [1]. The enzyme from the bacterium Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC strain 8724 is involved in the methionine salvage pathway." +"1.13.11.54"," Requires iron(II). If Ni2+ is bound instead of iron(II), the reaction catalysed by EC 1.13.11.53, acireductone dioxygenase (Ni2+-requiring), occurs instead. The enzyme from the bacterium Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC strain 8724 is involved in the methionine salvage pathway." +"1.13.11.55","This enzyme, which is found in thermophilic microorganisms, contains one mononuclear none-heme iron centre per subunit. Elemental sulfur is both the electron donor and one of the two known acceptors, the other being oxygen. Thiosulfate is also observed as a product, but is likely formed non-enzymically by a reaction between sulfite and sulfur [1]. This enzyme differs from EC 1.13.11.18, persulfide dioxygenase and EC 1.12.98.4, sulfhydrogenase, in that both activities occur simultaneously." +"1.13.12.14","Chlorophyll b is required for the assembly of stable light-harvesting complexes (LHCs) in the chloroplast of green algae, cyanobacteria and plants [2,3]. Contains a mononuclear iron centre [3]. The enzyme catalyses two successive hydroxylations at the 7-methyl group of chlorophyllide a. The second step yields the aldehyde hydrate, which loses H2O spontaneously to form chlorophyllide b [2]. Chlorophyll a and protochlorophyllide a are not substrates [2]." +"1.14.13.101","A flavoprotein. NADH cannot replace NADPH. While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates [1]. Senecionine N-oxide is used by insects as a chemical defense: senecionine N-oxide is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P-450 oxidase when absorbed by insectivores." +"1.17.99.4","Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95 (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 [dihydrouracil dehydrogenase (NAD+)] or EC 1.3.1.2 [dihydropyrimidine dehydrogenase (NADP+)], EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6 (beta-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH3 and CO2 [5]." +"2.3.1.177","A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC 2.3.1.151, benzophenone synthase." +"2.3.1.178","Requires Na+ or K+ for maximal activity [3]. Ornithine, lysine, aspartate, and alpha-, beta- and gamma-aminobutanoate cannot act as substrates [3]. However, acetyl-CoA can be replaced by propanoyl-CoA, although the reaction proceeds more slowly [3]. Forms part of the ectoine-biosynthesis pathway." +"2.3.1.179"," Involved in the dissociated (or type II) fatty acid biosynthesis system that occurs in plants and bacteria. While the substrate specificity of this enzyme is very similar to that of EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, it differs in that palmitoleoyl-[acyl-carrier protein] is not a good substrate of EC 2.3.1.41 but is an excellent substrate of this enzyme [1,2]. The fatty-acid composition of Escherichia coli changes as a function of growth temperature, with the proportion of unsaturated fatty acids increasing with lower growth temperature. This enzyme controls the temperature-dependent regulation of fatty-acid composition, with mutants lacking this acivity being deficient in the elongation of palmitoleate to cis-vaccenate at low temperatures [3,4]. " +"2.3.1.180","The enzyme is responsible for initiating straight-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. In contrast to EC 2.3.1.41, beta-ketoacyl-[acyl-carrier-protein] synthase I, and EC 2.3.1.179, beta-ketoacyl-[acyl-carrier-protein] synthase II, this enzyme specifically uses short-chain acyl-CoA thioesters (preferably acetyl-CoA) rather than acyl-[acp] as its substrate [1]. The enzyme can also catalyse the reaction of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, but to a much lesser extent [1]. The enzymes from some organisms (e.g. the Gram-positive bacterium Streptococcus pneumoniae) can accept branched-chain acyl-CoAs in addition to acetyl-CoA [5] (cf. EC 2.3.1.300, branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase)." +"2.3.1.300","The enzyme is responsible for initiating branched-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system (FAS-II) in some bacteria, using molecules derived from degradation of the branched-chain amino acids L-leucine, L-valine, and L-isoleucine to form the starting molecules for elongation by the FAS-II system. In some organisms the enzyme is also able to use acetyl-CoA, leading to production of a mix of branched-chain and straight-chain fatty acids [3] (cf. EC 2.3.1.180, beta-ketoacyl-[acyl-carrier-protein] synthase III)." +"2.3.1.181","This is the first committed step in the biosynthesis of lipoyl cofactor. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [2,3]. Lipoyl-ACP can also act as a substrate [4] although octanoyl-ACP is likely to be the true substrate [6]. The other enzyme involved in the biosynthesis of lipoyl cofactor is EC 2.8.1.8, lipoyl synthase. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues). " +"2.4.1.244","The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." +"2.6.1.81","A pyridoxal-phosphate protein. Also acts on N2-acetyl-L-ornithine and L-ornithine, but more slowly [3]. In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, acetylornithine transaminase (EC 2.6.1.11) and ornithine aminotransferase (EC 2.6.1.13) activities are catalysed by the same enzyme, but this is not the case in all species [5]. This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6]. " +"2.6.99.2","In Escherichia coli, the cofactor pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3]." +"2.7.1.158","The enzyme can also use Ins(1,4,5,6)P4 [2] and Ins(1,4,5)P3 [3] as substrate. Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolysed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment [5]." +"2.7.1.159"," In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2]. The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase. " +"2.7.4.22","This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1]." +"2.7.7.63"," Requires Mg2+. Both 6S- and 6R-lipoates can act as substrates but there is a preference for the naturally occurring R-form. Selenolipoate, i.e. 5-(1,2-diselenolan-3-yl)pentanoic acid, and 6-sulfanyloctanoate can also act as substrates, but more slowly [2]. This enzyme is responsible for lipoylation in the presence of exogenous lipoic acid [7]. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [6]. This enzyme attaches lipoic acid to the lipoyl domains of these proteins, converting apoproteins into holoproteins. It is likely that an alternative pathway, involving EC 2.3.1.181, lipoyl(octanoyl) transferase and EC 2.8.1.8, lipoyl synthase, is the normal route for lipoylation [7]." +"2.7.7.90","The enzyme, characterized from the bacterium Shewanella oneidensis MR-1, acts on the 8-aminated from of 3-deoxy-alpha-D-manno-octulosonate (Kdo). cf. EC 2.7.7.38, 3-deoxy-manno-octulosonate cytidylyltransferase." +"2.4.1.243","Inulins are polysaccharides consisting of linear or branched D-fructofuranosyl chains attached to the fructosyl residue of sucrose by a beta(2->1) linkage. This enzyme catalyses the transfer of the terminal (2->1)-linked -D-fructosyl group of an inulin chain onto O-6 position of the glucose residue of another inulin molecule [1]. For example, if 1-kestose [1F-(beta-D-fructofuranosyl)sucrose] is both the donor and recipient in the reaction shown above, i.e., if m = 1 and n = 1, then the products will be sucrose and 6G-di-beta-D-fructofuranosylsucrose. In this notation, the superscripts F and G are used to specify whether the fructose or glucose residue of the sucrose carries the substituent. Alternatively, this may be indicated by the presence and/or absence of primes (see {iupac/2carb/36#362::http://www.chem.qmul.ac.uk/iupac/2carb/36.html#362}). Sucrose cannot be a donor substrate in the reaction (i.e. m cannot be zero) and inulin cannot act as an acceptor. Side reactions catalysed are transfer of a beta-D-fructosyl group between compounds of the structure 1F-(1-beta-D-fructofuranosyl)m-6G-(1-beta-D-fructofuranosyl)n sucrose, where m >= 0 and n = 1 for the donor, and m >= 0 and n >= 0 for the acceptor. " +"2.8.1.8","This enzyme catalyses the final step in the de-novo biosynthesis of the lipoyl cofactor, the attachment of two sulfhydryl groups to C6 and C8 of a pendant octanoyl chain. It is a member of the 'AdoMet radical' (radical SAM) family, all members of which produce the 5'-deoxyadenosin-5'-yl radical and methionine from AdoMet (S-adenosylmethionine) by the addition of an electron from an iron-sulfur centre. The enzyme contains two [4Fe-4S] clusters. The first cluster produces the radicals, which are converted into 5'-deoxyadenosine when they abstract hydrogen atoms from C6 and C8, respectively, leaving reactive radicals at these positions that interact with sulfur atoms within the second (auxiliary) cluster. Having donated two sulfur atoms, the auxiliary cluster is degraded during catalysis, but is regenerated immediately by the transfer of a new cluster from iron-sulfur cluster carrier proteins [8]. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, as it converts apoprotein into the biologically active holoprotein. Examples of such lipoylated proteins include pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [1,2]. An alternative lipoylation pathway involves EC 6.3.1.20, lipoate---protein ligase, which can lipoylate apoproteins using exogenous lipoic acid (or its analogues) [4]." +"3.1.3.76","Requires Mg2+ for maximal activity. The enzyme from mammals is a bifunctional enzyme: the N-terminal domain exhibits lipid-phosphate-phosphatase activity and the C-terminal domain has the activity of EC 3.3.2.10, soluble epoxide hydrolase (sEH) [1]. The best substrates for this enzyme are 10-hydroxy-9-(phosphooxy)octadecanoates, with the threo- form being a better substrate than the erythro- form [1]. The phosphatase activity is not found in plant sEH or in EC 3.3.2.9, microsomal epoxide hydrolase, from mammals [1]." +"3.1.13.5","Requires divalent cations for activity (Mg2+, Mn2+ or Co2+). Alteration of the 3'-terminal base has no effect on the rate of hydrolysis whereas modification of the 3'-terminal sugar has a major effect. tRNA terminating with a 3'-phosphate is completely inactive [3]. This enzyme can convert a tRNA precursor into a mature tRNA [2]." +"3.2.1.155","The enzyme removes branched oligosaccharides, containing preferentially four glucoside residues in the main chain, from xyloglucan molecules in a processive manner after the initial endo-type attack on a polysaccharide [1-5]. Hydrolysis occurs at either the unsubstituted D-glucopyranose residue in the main backbone and/or the D-glucopyranose residue bearing a xylosyl group [1-5]. The enzyme does not display activity, or shows very low activity, towards other beta-D-glucans [1,2,4,5]." +"3.2.1.157"," The main products of hydrolysis are iota-neocarratetraose sulfate and iota-neocarrahexaose sulfate. iota-Neocarraoctaose is the shortest substrate oligomer that can be cleaved. Unlike EC 3.2.1.81, beta-agarase and EC 3.2.1.83, kappa-carrageenase, this enzyme proceeds with inversion of the anomeric configuration. iota-Carrageenan differs from kappa-carrageenan by possessing a sulfo group on O-2 of the 3,6-anhydro-D-galactose residues, in addition to that present in the kappa-compound on O-4 of the D-galactose residues." +"3.2.1.158","Requires Ca2+. The enzyme from Thalassomonas sp. can use agarose, agarohexaose and neoagarohexaose as substrate. The products of agarohexaose hydrolysis are dimers and tetramers, with agarotetraose being the predominant product, whereas hydrolysis of neoagarohexaose gives rise to two types of trimer. While the enzyme can also hydrolyse the highly sulfated agarose porphyran very efficiently, it cannot hydrolyse the related compounds kappa-carrageenan (see EC 3.2.1.83) and iota-carrageenan (see EC 3.2.1.157) [2]. See also EC 3.2.1.81, beta-agarase." +"3.2.1.159","When neoagarohexaose is used as a substrate, the oligosaccharide is cleaved at the non-reducing end to produce 3,6-anhydro-L-galactose and agaropentaose, which is further hydrolysed to agarobiose and agarotriose. With neoagarotetraose as substrate, the products are predominantly agarotriose and 3,6-anhydro-L-galactose. In Vibrio sp. the actions of EC 3.2.1.81, beta-agarase and EC 3.2.1.159 can be used to degrade agarose to 3,6-anhydro-L-galactose and D-galactose." +"3.2.1.161","The enzyme from the tropical tree Dalbergia nigrescens Kurz belongs in glycosyl hydrolase family 1. The enzyme removes disaccharides from the natural substrates dalpatein 7-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside and 7-hydroxy-2',4',5',6-tetramethoxy-7-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside (dalnigrein 7-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside) although it can also remove a single glucose residue from isoflavonoid 7-O-glucosides [2]. Daidzin and genistin are also substrates." +"3.3.2.9","This is a key hepatic enzyme that catalyses the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols. The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to the corresponding trans-dihydrodiols. The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate. Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase)." +"3.3.2.10","Catalyses the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism [7]. It is involved in the metabolism of arachidonic epoxides (epoxyicosatrienoic acids; EETs) and linoleic acid epoxides. The EETs, which are endogenous chemical mediators, act at the vascular, renal and cardiac levels to regulate blood pressure [4,5]. The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76, lipid-phosphate phosphatase [1,2]. Like EC 3.3.2.9, microsomal epoxide hydrolase, it is probable that the reaction involves the formation of an hydroxyalkyl---enzyme intermediate [4,6]. The enzyme can also use leukotriene A4, the substrate of EC 3.3.2.6, leukotriene-A4 hydrolase, but it forms 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid rather than leukotriene B4 as the product [9,10]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [7]." +"3.3.2.11","The activity has been attributed to the microsomal antiestrogen binding site, a complex formed by EC 5.3.3.5, cholestenol Delta-isomerase, and EC 1.3.1.21, 7-dehydrocholesterol reductase [6]. Both 5,6alpha-epoxy-5alpha-cholestan-3beta-ol and 5,6beta-epoxy-5beta-cholestan-3beta-ol are substrates [3]. The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase) [3]." +"3.4.23.49","A product of the ompT gene of Escherichia coli, and associated with the outer membrane. Omptin shows a preference for cleavage between consecutive basic amino acids, but is capable of cleavage when P1' is a non-basic residue [5,7]. Belongs in peptidase family A26." +"3.5.1.94"," Forms part of a putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form gamma-glutamylputrescine, which is oxidized to 4-(gamma-glutamylamino)butanal and then to 4-(gamma-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase)." +"3.5.1.95"," Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.2.1 (barbiturase)." +"3.5.1.96","Requires Co2+ for maximal activity [1]. N2-Acetylglutamate is not a substrate. This is the final enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.11 (acetylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase)." +"3.5.3.23","Arginine, N2-acetylarginine and N2-glutamylarginine do not act as substrates [3]. This is the second enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase)." +"4.1.1.86","A pyridoxal-phosphate protein that requires a divalent cation for activity [1]. N4-Acetyl-L-2,4-diaminobutanoate, 2,3-diaminopropanoate, ornithine and lysine are not substrates. Found in the proteobacteria Haemophilus influenzae and Acinetobacter baumannii. In the latter, this enzyme is cotranscribed with the dat gene that encodes EC 2.6.1.76, diaminobutyrate---2-oxoglutarate transaminase, which can supply the substrate for this enzyme." +"4.1.3.39","Requires Mn2+ for maximal activity [1]. The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH [1]. In some bacterial species the enzyme forms a bifunctional complex with EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase [4,5]." +"4.2.1.108","Ectoine is an osmoprotectant that is found in halophilic eubacteria. This enzyme is part of the ectoine biosynthesis pathway and only acts in the direction of ectoine formation. cf. EC 3.5.4.44, ectoine hydrolase." +"4.2.3.22","Requires Mg2+ for activity. H-1si of farnesyl diphosphate is lost in the formation of (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol. Formation of (-)-germacrene D involves a stereospecific 1,3-hydride shift of H-1si of farnesyl diphosphate. Both products are formed from a common intermediate [2]. Other enzymes produce germacrene D as the sole product using a different mechanism. The enzyme mediates a key step in the biosynthesis of geosmin (see EC 4.1.99.16 geosmin synthase), a widely occurring metabolite of many streptomycetes, bacteria and fungi [2]. Also catalyses the reaction of EC 4.2.3.75, (-)-germacrene D synthase." +"4.2.3.24","Requires Mg2+ and Mn2+ for activity. This is a key enzyme in the biosynthesis of the antimalarial endoperoxide artemisinin [3]. Catalyses the formation of both olefinic [e.g. amorpha-4,11-diene, amorpha-4,7(11)-diene, gamma-humulene and beta-sesquiphellandrene] and oxygenated (e.g. amorpha-4-en-7-ol) sesquiterpenes, with amorpha-4,11-diene being the major product. When geranyl diphosphate is used as a substrate, no monoterpenes are produced [2]." +"4.2.3.25"," Requires Mn2+ or Mg2+ for activity. Neither (S)- nor (R)-linalyl diphosphate can act as substrate for the enzyme from the flower Clarkia breweri [1]. Unlike many other monoterpene synthases, only a single product, (3S)-linalool, is formed." +"4.2.3.26","Geranyl diphosphate cannot be replaced by isopentenyl diphosphate (3-methylbut-3-en-1-yl diphosphate), prenyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate [1]. Requires Mg2+ or Mn2+ for activity. Unlike many other monoterpene synthases, only a single product, (3R)-linalool, is formed." +"4.4.1.24",Requires iron(II). This inducible enzyme participates in cysteate degradation by the bacterium Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation by the bacterium Chromohalobacter salexigens. The enzyme is specific for the (R) isomer of its substrate. +"4.4.1.25"," A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogensulfite and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. D-Cysteine can also act as a substrate, but more slowly. It is converted into hydrogen sulfide, pyruvate, and ammonia. This inducible enzyme from the marine bacterium Silicibacter pomeroyi DSS-3 forms part of the cysteate-degradation pathway." +"5.3.3.14","While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs [3]. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis." +"5.4.99.18","In eubacteria, fungi and plants, this enzyme, along with EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase, is required to carry out the single reaction catalysed by EC 4.1.1.21, phosphoribosylaminoimidazole carboxylase, in vertebrates [6]. In the absence of EC 6.3.2.6, phosphoribosylaminoimidazolesuccinocarboxamide synthase, the reaction is reversible [3]. The substrate is readily converted into 5-amino-1-(5-phospho-D-ribosyl)imidazole by non-enzymic decarboxylation [3]." +"6.3.4.18"," In Escherichia coli, this enzyme, along with EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase, is required to carry out the single reaction catalysed by EC 4.1.1.21, phosphoribosylaminoimidazole carboxylase, in vertebrates. Belongs to the ATP grasp protein superfamily [3]. Carboxyphosphate is the putative acyl phosphate intermediate. Involved in the late stages of purine biosynthesis." +"4.2.3.23","Requires Mg2+ for activity. While germacrene A is an enzyme-bound intermediate in the biosynthesis of a number of phytoalexins, e.g. EC 4.2.3.9 (aristolochene synthase) from some species and EC 4.2.3.21 (vetispiradiene synthase), it is the sole sesquiterpenoid product formed in chicory [1]." +"1.5.1.35","1-Pyrroline forms spontaneously from 4-aminobutanal, produced by EC 2.6.1.82, putrescine aminotransferase. This enzyme forms part of the arginine-catabolism pathway [3]." +"1.8.4.11","The reaction occurs in the reverse direction to that shown above. The enzyme exhibits high specificity for the reduction of the S-form of L-methionine S-oxide, acting faster on the residue in a peptide than on the free amino acid [9]. On the free amino acid, it can also reduce D-methionine (S)-S-oxide but more slowly [9]. The enzyme plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged. In some species, e.g. Neisseria meningitidis, both this enzyme and EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, are found within the same protein whereas, in other species, they are separate proteins [1,4]. The reaction proceeds via a sulfenic-acid intermediate [5,10]." +"1.8.4.12","The reaction occurs in the reverse direction to that shown above. The enzyme exhibits high specificity for reduction of the R-form of methionine S-oxide, with higher activity being observed with L-methionine S-oxide than with D-methionine S-oxide [9]. While both free and protein-bound methionine (R)-S-oxide act as substrates, the activity with the peptide-bound form is far greater [10]. The enzyme plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged. In some species, e.g. Neisseria meningitidis, both this enzyme and EC 1.8.4.11, peptide-methionine (S)-S-oxide reductase, are found within the same protein whereas in other species, they are separate proteins [3,5]. The reaction proceeds via a sulfenic-acid intermediate [5,10]. For MsrB2 and MsrB3, thioredoxin is a poor reducing agent but thionein works well [11]. The enzyme from some species contains selenocysteine and Zn2+. " +"1.8.4.13","Requires NADPH [2]. The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC 1.8.4.14, L-methionine (R)-S-oxide reductase]." +"1.8.4.14","Requires NADPH. Unlike EC 1.8.4.12, peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC 1.8.4.13, L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate." +"1.14.11.27","Requires iron(II). Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys36. Lysine residues exist in three methylation states (mono-, di- and trimethylated). The enzyme preferentially demethylates the dimethyl form of Lys36 (K36me2), which is its natural substrate, to form the monomethylated and unmethylated forms of Lys36. It can also demethylate monomethylated (but not the trimethylated) Lys36. cf. EC 1.14.11.69, [histone H3]-trimethyl-L-lysine36 demethylase." +"2.6.1.82","A pyridoxal 5'-phosphate protein [3]. The product, 4-aminobutanal, spontaneously cyclizes to form 1-pyrroline, which may be the actual substrate for EC 1.2.1.19, aminobutyraldehyde dehydrogenase. Cadaverine and spermidine can also act as substrates [3]. Forms part of the arginine-catabolism pathway [2]. cf. EC 2.6.1.113, putrescine---pyruvate transaminase." +"2.6.1.83","A pyridoxal-phosphate enzyme. In vivo, the reaction occurs in the opposite direction to that shown above. This is one of the final steps in the lysine-biosynthesis pathway of plants (ranging from mosses to flowering plants). meso-Diaminoheptanedioate, an isomer of LL-2,6-diaminoheptanedioate, and the structurally related compounds lysine and ornithine are not substrates. 2-Oxoglutarate cannot be replaced by oxaloacetate or pyruvate. It is not yet known if the substrate of the biosynthetic reaction is the cyclic or acyclic form of tetrahydropyridine-2,6-dicarboxylate." +"2.7.1.160","Catalyses the final step of tRNA splicing in the yeast Saccharomyces cerevisiae [2]. The reaction takes place in two steps: in the first step, the 2'-phosphate on the RNA substrate is ADP-ribosylated, causing the relase of nicotinamide and the formation of the reaction intermediate, ADP-ribosylated tRNA [6]. In the second step, dephosphorylated (mature) tRNA is formed along with ADP ribose 1''-2''-cyclic phosphate. Highly specific for oligonucleotide substrates bearing an internal 2'-phosphate. Oligonucleotides with only a terminal 5'- or 3'-phosphate are not substrates [1]. " +"2.7.4.23","This enzyme, found in NAD supression mutants of Escherichia coli, synthesizes 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) without the participation of EC 2.7.6.1, ribose-phosphate diphosphokinase. Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor." +"3.1.1.80","This plant enzyme is responsible for the last stages in the biosynthesis of the indole alkaloid ajmaline. The enzyme is highly specific for the substrates 17-O-acetylajmaline and 17-O-acetylnorajmaline as the structurally related acetylated alkaloids vinorine, vomilenine, 1,2-dihydrovomilenine and 1,2-dihydroraucaffricine cannot act as substrates [2]. This is a novel member of the GDSL family of serine esterases/lipases." +"3.1.3.77","This bifunctional enzyme first enolizes the substrate to form the intermediate 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate, which is then dephosphorylated to form the acireductone 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one [2]. The acireductone represents a branch point in the methione-salvage pathway as it is used in the formation of formate, CO and 3-(methylsulfanyl)propanoate by EC 1.13.11.53 [acireductone dioxygenase (Ni2+-requiring)] and of formate and 4-(methylsulfanyl)-2-oxobutanoate either by a spontaneous reaction under aerobic conditions or by EC 1.13.11.54 {acireductone dioxygenase [iron(II)-requiring]} [1,2]." +"4.2.1.109",This enzyme forms part of the methionine-salvage pathway. +"4.2.2.20","This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1-3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [5]. The related enzyme EC 4.2.2.21, chondroitin-sulfate-ABC exolyase, has the same substrate specificity but removes disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments produced by EC 4.2.2.20 [4]." +"4.2.2.21","This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. The related enzyme EC 4.2.2.20, chondroitin-sulfate-ABC endolyase, has the same substrate specificity but produces a mixture of oligosaccharides of different sizes that are ultimately degraded to tetra- and disaccharides [4]. Both enzymes act by the removal of a relatively acidic C-5 proton of the uronic acid followed by the elimination of a 4-linked hexosamine, resulting in the formation of an unsaturated C4---C5 bond on the hexuronic acid moiety of the products [4,6]." +"4.2.99.21","This enzyme is part of the pathway of salicylate formation from chorismate, and forms an integral part of pathways that produce salicylate-derived siderophores, such as pyochelin and yersiniabactin." +"6.3.2.28","The enzyme from Bacillus sp. requires Mg2+ or Mn2+ for activity. While the enzyme has extremely broad substrate specificity, it does not accept highly charged amino acids, such as Lys, Arg, Glu and Asp, nor does it react with secondary amines such as Pro. The N-terminal residue of the -dipeptide formed seems to be limited to Ala, Gly, Ser, Thr and Met (with Ala and Ser being the most preferred), whereas the C-terminal residue seems to allow for a wider variety of amino acids (but with a preference for Met and Phe). However, not all combinations or dipeptides are formed. For example, while Ser is acceptable for the N-terminus and Thr for the C-terminus, a Ser-Thr dipeptide is not formed. D-Ala, D-Ser and D-Phe are not substrates. Belongs in the ATP-dependent carboxylate-amine/thiol ligase superfamily." +"4.1.2.8","Forms part of the defence mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyses the first committed step in the formation of the cyclic hydroxamic acids 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) [1]. This enzyme resembles the alpha-subunit of EC 4.2.1.20, tryptophan synthase [3], for which, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate is also a substrate, but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released [2]." +"1.14.11.28","Requires iron(II) for activity. Unlike the proline hydroxylases involved in collagen biosynthesis [EC 1.14.11.2 (procollagen-proline dioxygenase) and EC 1.14.11.7 (procollagen-proline 3-dioxygenase)], this enzyme does not require ascorbate for activity although it does increase the activity of the enzyme [2]. The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not substrates [2]." +"1.17.99.5","Under physiological conditions, the reactions occur in the reverse direction to that shown above. This enzyme is highly specific for bile-acid substrates and requires a free C-24 carboxy group and an unhindered 7alpha-hydroxy group on the B-ring of the steroid nucleus for activity, as found in cholate and chenodeoxycholate. The reaction is stimulated by the presence of NAD+ but is inhibited by excess NADH. This unusual regulation by the NAD+/NADH ratio is most likely the result of the intermediates being linked at C-24 by an anhydride bond to the 5'-diphosphate of 3'-phospho-ADP [2,5,6]. Allo-deoxycholate is also formed as a side-product of the 7alpha-dehydroxylation of cholate [6]. The enzyme is present in intestinal anaerobic bacteria [6], even though its products are important in mammalian physiology." +"3.4.14.12","This cell-surface-associated serine exopeptidase is found in the Gram-negative, anaerobic bacterium Porphyromonas gingivalis, which has been implicated in adult periodontal disease [1]. The enzyme releases the N-terminal tripeptide of peptides, such as interleukin-6. It has an absolute requirement for a proline residue at the P1 position but is completely inactivated by a proline residue at the P1' position [1]. The size of the peptide does not affect the rate of reaction [1]." +"3.4.21.106","This type-II membrane-associated serine peptidase has been implicated in cell growth and development [1,3]. The enzyme has been shown to activate blood coagulation factor VII by cleavage of the Arg152!Ile153 peptide bound in BHK cells, thus indicating a possible role in the initiation of blood coagulation [2]. There is no cleavage after aromatic or aliphatic residues [1]. The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphatic residue. The nature of the residue at S3 also affects hydrolysis, with Gln being much more favourable than Ala [1]. Belongs in peptidase family S1A." +"3.4.21.107","This serine endopeptidase is essential for the clearance of denatured or aggregated proteins from the inner-membrane and periplasmic space in Escherichia coli. Natural substrates of the enzyme include colicin A lysis protein, pilin subunits and MalS from E. coli [3]. The enzyme has weak peptidase activity with casein and other non-native substrates [3]. The peptidase acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures [1,6]. Molecular chaperones and peptidases control the folded state of proteins by recognizing hydrophobic stretches of polypeptide that become exposed by misfolding or unfolding. They then bind these hydrophobic substrates to prevent aggregation or assist in protein refolding. If attempts at refolding fail, then irreversibly damaged proteins are degraded by peptidases such as this enzyme [6]. Belongs in peptidase family S1C." +"3.4.21.108",This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment [4]. It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP) [3]. Belongs in peptidase family S1C. +"3.4.21.109","This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis [1,2]. The enzyme can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain forms at an Arg residue to give active alpha- and beta-HGF, but It does not activate plasminogen, which shares high homology with HGF [1]. The enzyme can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade [1,2]. Hemojuvelin has been shown to be a physiological substrate for matriptase-2 [5]. Belongs in peptidase family S1A." +"3.4.21.110","This enzyme is a surface-associated subtilisin-like serine peptidase with very specific substrate specificity. Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a. Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties [1,4]. Belongs in peptidase family S8A." +"3.4.21.111","This enzyme from the extreme thermophile, Thermus aquaticus, is an alkaline serine peptidase. It has three subsites, S1, S2, and S3, in the substrate binding site. The preferred amino acids at the S1 site are Ala and Phe, at the S2 site are Ala and norleucine and at the S3 site are Phe and Ile [3]. These specificities are similar to those of EC 3.4.21.64 (peptidase K) and EC 3.4.21.62 (subtilisin BPN') [3]. The enzyme displays broad specificity for cleavage of insulin B-chain and hydrolyses elastin substrates such as succinyl-(Ala)n-p-nitroanilide (n = 1,2,3) and some peptide esters [1,3]. Belongs in peptidase family S8A." +"3.4.21.112","Cleaves sterol regulatory element-binding proteins (SREBPs) and thereby initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholesterol and unsaturated fatty acids into the bloodstream [1]. The enzyme also processes pro-brain-derived neurotrophic factor and undergoes autocatalytic activation in the endoplasmic reticulum through sequential cleavages [5]. The enzyme can also process the unfolded protein response stress factor ATF6 at an Arg-His-Lys-Lys! site [4,8], and the envelope glycoprotein of the highly infectious Lassa virus [5,8] and Crimean Congo hemorrhagic fever virus at Arg-Arg-Lys-Lys! [7,8]. Belongs in peptidase family S8A." +"3.4.21.114","In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab polyproteins. This enzyme is the main viral proteinase and processes five cleavage sites in the ORF1a protein and three in the ORF1b-encoded part of the ORF1ab protein to yield nonstructural proteins (nsp5-nsp12) [3]. It combines the catalytic system of a chymotrypsin-like serine peptidase (His-Asp-Ser catalytic triad) with the substrate specificity of a 3C-like serine peptidase (Glu or Gln) at the P1 position and a small amino-acid residue (Gly, Ser or Ala) at the P1' position [1]. Cleavage of ORF1ab by this enzyme is essential for viral replication [2]. Belongs in peptidase family S32." +"3.4.21.115","Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish [2]. As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus [2]. pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2. This cleavage is most likely due to host-cell proteases rather than VP4 [2,3]. Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp [2]. Belongs in peptidase family S50." +"3.4.21.116","This enzyme plays a central role in a regulatory checkpoint (the sigmaK checkpoint), which coordinates gene expression during the later stages of spore formation in Bacillus subtilis [1,3]. The enzyme activates proteolytic processing of a sporulation-specific sigma factor, pro-sigmaK, to its mature and active form, sigmaK, by self-cleavage [1,3]. The enzyme is also subject to secondary proteolysis, which presumably inactivates SpoIVB [3]. The enzyme is also essential for the formation of heat-resistant spores. Belongs in peptidase family S55." +"3.4.21.117","This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at Leu6!Cya7, Tyr16!Leu17, Phe25!Tyr26 and Tyr26!Thr27 [1]. It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures [1,2]. Belongs in peptidase family S1A." +"3.4.21.118","The enzyme is activated by removal of an N-terminal prepropeptide [2,4]. The highest amidolytic activity is observed using Boc-Val-Pro-Arg!7-amido-4-methylcoumarin, which is a substrate of alpha-thrombin [2,4]. Substrates lacking basic amino acids in the P1 position are not cleaved [4]. The enzyme degrades casein, fibronectin, gelatin, collagen type IV, fibrinogen, and high-molecular-mass kininogen [3] and is associated with diseases such as ovarian cancer and Alzheimer's disease [4]. Belongs in peptidase family S1A." +"3.4.21.119","The enzyme is specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates [1]. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. This enzyme is also able to process pro-interleukin-1beta (pro-IL-1beta) in mouse submandibular gland to form IL-1beta [4]. Belongs in peptidase family S1A." +"1.4.3.20","Differs from EC 1.4.3.13, protein-lysine 6-oxidase, by using free L-lysine rather than the protein-bound form. N2-Acetyl-L-lysine is also a substrate, but N6-acetyl-L-lysine, which has an acetyl group at position 6, is not a substrate. Also acts on L-ornithine, D-lysine and 4-hydroxy-L-lysine, but more slowly. The amines cadaverine and putrescine are not substrates [2]." +"3.4.21.113","The polyprotein of noncytopathogenic pestiviruses is cleaved co- and post-translationally into at least 11 proteins (Npro, C, Erns, E1, E2, p7, NS2-3, NS4A, NS4B, NS5A, and NS5B) [2]. The genomes of cytopathogenic pestivirus strains express at least one additional protein, called NS3 (p80) [2]. This enzyme, which resides in the N-terminal region of NS3 (nonstructural protein 3), is essential for generation of its own C-terminus and for processing of the downstream cleavage sites, leading to the release of the pestivirus nonstructural proteins NS4A, NS4B, NS5A and NS5B [1,2]. Belongs in peptidase family S31." +"1.1.1.291","NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase)." +"1.1.99.31","This enzyme is a member of the FMN-dependent alpha-hydroxy-acid oxidase/dehydrogenase family [1]. While all enzymes of this family oxidize the (S)-enantiomer of an alpha-hydroxy acid to an alpha-oxo acid, the ultimate oxidant (oxygen, intramolecular heme or some other acceptor) depends on the particular enzyme. This enzyme transfers the electron pair from FMNH2 to a component of the electron transport chain, most probably ubiquinone [1,2]. It is part of a metabolic pathway in Pseudomonads that allows these organisms to utilize mandelic acid, derivatized from the common soil metabolite amygdalin, as the sole source of carbon and energy [2]. The enzyme has a large active-site pocket and preferentially binds substrates with longer sidechains, e.g. 2-hydroxyoctanoate rather than 2-hydroxybutyrate [1]. It also prefers substrates that, like (S)-mandelate, have beta unsaturation, e.g. (indol-3-yl)glycolate compared with (indol-3-yl)lactate [1]. Esters of mandelate, such as methyl (S)-mandelate, are also substrates [3]." +"1.3.3.12","A flavoprotein. Acts on the 1,4-lactones of L-galactonic, D-altronic, L-fuconic, D-arabinic and D-threonic acids; not identical with EC 1.1.3.8 L-gulonolactone oxidase. (cf. EC 1.3.2.3 galactonolactone dehydrogenase)." +"2.7.7.64","Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-Fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates [1]." +"2.7.8.27","The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2]." +"3.4.13.22","A Zn2+-dependent enzyme [4]. The enzyme protects Enterococcus faecium from the antibiotic vancomycin, which can bind to the -D-Ala-D-Ala sequence at the C-terminus of the peptidoglycan pentapeptide (see diagram). This enzyme reduces the availability of the free dipeptide D-Ala-D-Ala, which is the precursor for this pentapeptide sequence, allowing D-Ala-(R)-lactate (for which vancomycin has much less affinity) to be added to the cell wall instead [2,3]. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates [2]. Belongs in peptidase family M15." +"3.5.2.18","Contains iron and Zn2+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 1.1.1.291 (2-hydroxymethylglutarate dehydrogenase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase). " +"4.2.1.110","This enzyme catalyses two of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. Aldose-2-uloses such as 2-dehydroglucose can also act as substrates, but more slowly [1,2,4]. This is a bifunctional enzyme that acts as both a lyase and as an isomerase [2]. Differs from EC 4.2.1.111, which can carry out only reaction (1a), is inhibited by its product and requires metal ions for activity [1]." +"4.2.1.111","This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.2.13 [exo-(1->4)-alpha-D-glucan lyase] and EC 5.3.2.7 (ascopyrone tautomerase). Requires divalent (Ca2+ or Mg2+) or monovalent cations (Na+) for optimal activity. Unlike EC 4.2.1.110, the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity towards aldose-2-uloses such as 2-dehydroglucose [1,2,3]. In addition, it is inhibited by its end-product ascopyrone M [2] and it cannot convert ascopyrone M into microthecin, as can EC 4.2.1.110." +"5.3.3.15","This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.1.111 (1,5-anhydro-D-fructose dehydratase) and EC 4.2.2.13 [exo-(1->4)-alpha-D-glucan lyase]. Ascopyrone P is an anti-oxidant [2]." +"6.3.1.12","This enzyme forms part of the peptidoglycan assembly pathway of Gram-positive bacteria grown in medium containing D-Asp. Normally, the side chains the acylate the 6-amino group of the L-lysine residue contain L-Ala-L-Ala but these amino acids are replaced by D-Asp when D-Asp is included in the medium. Hybrid chains containing L-Ala-D-Asp, L-Ala-L-Ala-D-Asp or D-Asp-L-Ala are not formed [4]. The enzyme belongs in the ATP-grasp protein superfamily [3,4]. The enzyme is highly specific for D-aspartate, as L-aspartate, D-glutamate, D-alanine, D-iso-asparagine and D-malic acid are not substrates [4]. In Enterococcus faecium, the substrate D-aspartate is produced by EC 5.1.1.13, aspartate racemase [4]" +"6.4.1.7","A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought [1] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, isocitrate dehydrogenase (NAD+), but this has since been disproved [2]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41 [2]." +"1.4.1.22",The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2]. +"3.2.1.160","The enzyme from Chrysosporium lucknowense is an endoglucanase, i.e., acquires the specificity of EC 3.2.1.151, xyloglucan-specific endo-beta-1,4-glucanase, when it acts on linear substrates without bulky substituents on the polymeric backbone (e.g. carboxymethylcellulose). However, it switches to an exoglucanase mode of action when bulky side chains are present (as in the case of xyloglucan). The enzyme can also act on barley beta-glucan, but more slowly." +"3.4.22.55","Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) [6]. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6]. Two forms of caspase-2 with antagonistic effects exist: caspase-2L induces programmed cell death and caspase-2S suppresses cell death [2,3,5]. Caspase-2 is activated by caspase-3 (EC 3.4.22.56), or by a caspase-3-like protease. Activation involves cleavage of the N-terminal prodomain, followed by self-proteolysis between the large and small subunits of pro-caspase-2 and further proteolysis into smaller fragments [3]. Proteolysis occurs at Asp residues and the preferred substrate for this enzyme is a pentapeptide rather than a tetrapeptide [5]. Apart from itself, the enzyme can cleave golgin-16, which is present in the Golgi complex and has a cleavage site that is unique for caspase-2 [4,5]. alphaII-Spectrin, a component of the membrane cytoskeleton, is a substrate of the large isoform of pro-caspase-2 (caspase-2L) but not of the short isoform (caspase-2S). Belongs in peptidase family C14." +"3.4.22.56","Caspase-3 is an effector/executioner caspase, as are caspase-6 (EC 3.4.22.59) and caspase-7 (EC 3.4.22.60) [5]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [3,5]. Procaspase-3 can be activated by caspase-1 (EC 3.4.22.36), caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) as well as by the serine protease granzyme B [1]. Caspase-3 can activate procaspase-2 (EC 3.4.22.55) [2]. Activation occurs by inter-domain cleavage followed by removal of the N-terminal prodomain [6]. Although Asp-Glu-(Val/Ile)-Asp is thought to be the preferred cleavage sequence, the enzyme can accommodate different residues at P2 and P3 of the substrate [4]. Like caspase-2, a hydrophobic residue at P5 of caspase-3 leads to more efficient hydrolysis, e.g. (Val/Leu)-Asp-Val-Ala-Asp! is a better substrate than Asp-Val-Ala-Asp! . This is not the case for caspase-7 [4]. Belongs in peptidase family C14." +"3.4.22.57"," This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [3,5,6]. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but, unlike caspase-1, it is very inefficient at generating mature interleukin-1beta (IL-1beta) from pro-IL-1beta [1,4]. Both this enzyme and caspase-5 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17) [3]. The caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO can also inhibit this enzyme, but more slowly [4]. Belongs in peptidase family C14." +"3.4.22.58","This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [3,5,6]. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but is very inefficient at generating mature interleukin-1beta (IL-1beta) from pro-IL-1beta [1,4]. Both this enzyme and caspase-4 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17) [3]. Unlike caspase-4, this enzyme can be induced by lipopolysaccharide [3]. Belongs in peptidase family C14." +"3.4.22.59","Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-7 (EC 3.4.22.60) [2]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [2]. Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC 3.4.22.61) and leads to the release of cytochrome c from the mitochondria. The release of cytochrome c is an essential component of the intrinsic apoptosis pathway [1]. The enzyme can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragmentation in the final phases of apoptosis [2,4,5,6]. Belongs in peptidase family C14." +"3.4.22.60","Caspase-7 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-6 (EC 3.4.22.59) [1]. These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype [2]. Although a hydrophobic residue at P5 of caspase-2 (EC 3.4.22.55) and caspase-3 leads to more efficient hydrolysis, the amino-acid residue at this location in caspase-7 has no effect [3]. Caspase-7 is activated by the initiator caspases [caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63)]. Removal of the N-terminal prodomain occurs before cleavage in the linker region between the large and small subunits [4]. Belongs in peptidase family C14." +"3.4.22.61","Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) [1]. Caspase-8 is the apical activator of the extrinsic (death receptor) apoptosis pathway, triggered by death receptor ligation [2]. It contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. This enzyme is linked to cell surface death receptors such as Fas [1,5]. When Fas is aggregated by the Fas ligand, procaspase-8 is recruited to the death receptor where it is activated [1]. The enzyme has a preference for Glu at P3 and prefers small residues, such as Gly, Ser and Ala, at the P1' position. It has very broad P4 specificity, tolerating substrates with Asp, Val or Leu in this position [2,3,4]. Endogenous substrates for caspase-8 include procaspase-3, the pro-apoptotic Bcl-2 family member Bid, RIP, PAK2 and the caspase-8 activity modulator FLIPL [4,5]. Belongs in peptidase family C14." +"3.4.22.62","Caspase-9 is an initiator caspase, as are caspase -2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63) [1]. Caspase-9 contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [1]. An alternatively spliced version of caspase-9 also exists, caspase-9S, that inhibits apoptosis, similar to the situation found with caspase-2 [1]. Phosphorylation of caspase-9 from some species by Akt, a serine-threonine protein kinase, inhibits caspase activity in vitro and caspase activation in vivo [1]. The activity of caspase-9 is increased dramatically upon association with the apoptosome but the enzyme can be activated without proteolytic cleavage [2,3]. Procaspase-3 is the enzyme's physiological substrate [2]. Belongs in peptidase family C14." +"3.4.22.63","Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62) [1]. Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-kappaB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation) [2]. Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp! to yield the pro-apoptotic p15 fragment. The p15 fragment is N-myristoylated and enhances the release of cytochrome c from mitochondria (which, in turn, initiatiates the intrinsic apoptosis pathway). Bid can be further cleaved by caspase-10 and granzyme B but not by caspase-3 or caspase-8 at Ile-Glu-Thr-Asp! to yield a p13 fragment that is not N-myristoylated [2]. Belongs in peptidase family C14." +"3.4.22.64","This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide [1]. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions [1,2]. Belongs in peptidase family C14." +"1.1.1.292","This enzyme is present in some but not all Rhizobium species and belongs in the GFO/IDH/MocA protein family [2]. This enzyme differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro-D-mannitol, can be further metabolized to D-mannose [1]. The enzyme also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. It does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones [1]." +"3.2.1.162","The enzyme from Pseudoalteromonas sp. is specific for lambda-carrageenan. iota-Carrageenan (see EC 3.2.1.157, iota-carrageenase), kappa-carrageenan (see EC 3.2.1.83, kappa-carrageenase), agarose and porphyran are not substrates." +"3.4.21.120","The egg envelope of the South African clawed frog (Xenopus laevis) is modified during transit of the egg through the pars rectus oviduct, changing the egg envelope from an unfertilizable form to a fertilizable form. This process involves the conversion of glycoprotein gp43 to gp41 (ZPC) by the pars recta protease oviductin. It is thought that the enzymically active protease molecule comprises the N-terminal protease domain coupled to two C-terminal CUB domains, which are related to the mammalian spermadhesin molecules implicated in mediating sperm-envelope interactions [2]. The enzyme is also found in the Japanese toad (Bufo japonicus) [3]. Belongs in peptidase family S1." +"3.4.22.54","This Ca2+-dependent enzyme is found in skeletal muscle and is genetically linked to limb girdle muscular dystrophy type 2A [1,4]. The enzyme is activated by autoproteolytic cleavage of insertion sequence 1 (IS1), which allows substrates and inhibitors gain access to the active site [4]. Substrates include the protein itself [3,4] and connectin/titin [2,5]. Belongs in peptidase family C2." +"3.11.1.3","Highly specific for phosphonopyruvate as substrate [2]. The reaction is not inhibited by phosphate but is inhibited by the phosphonates phosphonoformic acid, hydroxymethylphosphonic acid and 3-phosphonopropanoic acid [2]. The enzyme is activated by the divalent cations Co2+, Mg2+ and Mn2+. This enzyme is a member of the phosphoenolpyruvate mutase/isocitrate lyase superfamily [3]." +"4.1.3.40",This enzyme catalyses the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria [1]. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine [3]. +"2.5.1.67","Requires a divalent metal ion for activity, with Mg2+ being better than Mn2+ [1]. Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. The mechanism of its formation is similar to that of the early steps of {terp/squalphyto::squalene and phytoene biosynthesis}. Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums." +"2.5.1.68","Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate." +"2.5.1.69","Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. When this enzyme is incubated with prenyl diphosphate and 3-methylbut-3-en-1-yl diphosphate, it also forms the regular monoterpene geranyl diphosphate [2]. The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67, chrysanthemyl diphosphate synthase) when prenyl diphosphate is the sole substrate." +"3.2.2.25","The enzyme preferentially hydrolyses 3- and 7-methylpurine nucleosides, such as 3-methylxanthosine, 3-methyladenosine and 7-methylguanosine. Hydrolysis of 7-methylxanthosine to form 7-methylxanthine is the second step in the caffeine-biosynthesis pathway." +"4.2.1.112","This is a non-redox-active enzyme that contains two molybdopterin guanine dinucleotide (MGD) cofactors, a tungsten centre and a cubane type [4Fe-4S] cluster [2].The tungsten centre binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct hydrophobic pocket [2]. Ethylene cannot act as a substrate [1]." +"4.2.3.27","Requires Mg2+ or Mn2+ for activity. This enzyme is located in the chloroplast of isoprene-emitting plants, such as poplar and aspen, and may be activitated by light-dependent changes in chloroplast pH and Mg2+ concentration [2,8]." +"2.1.1.158","The enzyme is specific for xanthosine, as XMP and xanthine cannot act as substrates [2,4]. The enzyme does not have N1- or N3- methylation activity [2]. This is the first methylation step in the production of caffeine. " +"2.1.1.159","This is the third enzyme in the caffeine-biosynthesis pathway. This enzyme can also catalyse the conversion of paraxanthine into caffeine, although the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis [2,3]. " +"2.1.1.160","Paraxanthine is the best substrate for this enzyme but the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis [2,3]." +"1.14.13.103","A membrane-bound cytochrome P-450 heme-thiolate monooxygenase that is associated with the endoplasmic reticulum [1,2]. This enzyme is specific for sophoraflavanone B as substrate. NADPH cannot be replaced by NADH, FAD or FMN. Along with EC 2.5.1.70 (naringenin 8-dimethylallyltransferase) and EC 2.5.1.71 (leachianone G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway." +"2.5.1.70","Requires Mg2+. This membrane-bound protein is located in the plastids [2]. In addition to naringenin, the enzyme can prenylate several other flavanones at the C-8 position, but more slowly. Along with EC 1.14.14.142 (8-dimethylallylnaringenin 2'-hydroxylase) and EC 2.5.1.71 (leachianone-G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway." +"2.5.1.71","This membrane-bound enzyme is located in the plastids and requires Mg2+ for activity. The reaction forms the lavandulyl sidechain of sophoraflavanone G by transferring a prenyl group to the 2'' position of another prenyl group attached at position 8 of leachianone G. The enzyme is specific for prenyl diphosphate as the prenyl donor, as it cannot be replaced by isopentenyl diphosphate or geranyl diphosphate. Euchrenone a7 (a 5-deoxy derivative of leachianone G) and kenusanone I (a 7-methoxy derivative of leachianone G) can also act as substrates, but more slowly. Along with EC 1.14.14.142 (8-dimethylallylnaringenin 2'-hydroxylase) and EC 2.5.1.70 (naringenin 8-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway." +"2.7.4.24","This enzyme is activated by osmotic shock [4]. Ins(1,3,4,5,6)P5, 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates [4]. The enzyme specifically phosphorylates the 1-position of the substrates [6]." +"2.8.2.36","The enzyme from the bacterium Streptomyces toyocaensis catalyses the final step in the biosynthesis of the glycopeptide antibiotic A47934, a naturally occuring antibiotic of the vancomycin group. " +"3.2.1.163","The enzyme is specific for (1->6)-linked mannobiose and has no activity towards any other linkages, or towards p-nitrophenyl-alpha-D-mannopyranoside or baker's yeast mannan. It is strongly inhibited by Mn2+ but does not require Ca2+ or any other metal cofactor for activity." +"1.14.13.102","This microsomal cytochrome P-450-dependent enzyme is specific for (+)-marmesin, and to a much lesser extent 5-hydroxymarmesin, as substrate. Furanocoumarins protect plants from fungal invasion and herbivore attack. (+)-Columbianetin, the angular furanocoumarin analogue of the linear furanocoumarin (+)-marmesin, is not a substrate for the enzyme but it is a competitive inhibitor." +"2.6.1.84","A pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked." +"3.4.22.65","This enzyme, derived from the house dust mite, is a major component of the allergic immune response [2]. The substrate specificity of this enzyme is not altogether clear. It cleaves the low-affinity IgE receptor CD23 at Glu298!Ser299 and Ser155!Ser156 [1]. It also cleaves the pulmonary structural proteins occludin and claudin at Leu!Leu, Asp!Leu and at Gly!Thr bonds [1,2]. It can also cleave the alpha subunit of the interleukin-2 (IL-2) receptor (CD25) [4]. Using a positional scanning combinatorial library, it was found that the major substrate-specificity determinant is for Ala in the P2 position [3]. The enzyme shows only a slight preference for basic amino acids in the P1 and P3 positions and a preference for aliphatic amino acids such as Ile, Pro, Val, Leu and norleucine in the P4 position [3]. Belongs in peptidase family C1A." +"2.3.1.182","One of the enzymes involved in a novel pyruvate pathway for isoleucine biosynthesis that is found in some, mainly archaeal, bacteria [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2]. " +"2.6.1.85","The enzyme is composed of two parts, a glutaminase (PabA in Escherichia coli) and an aminotransferase (PabB). In the absence of PabA and glutamine (but in the presence of Mg2+), PabB can convert ammonia and chorismate into 4-amino-4-deoxychorismate. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate. cf. EC 2.6.1.123, 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming)." +"3.2.1.164","The enzyme specifically hydrolyses 1,6-beta-D-galactooligosaccharides with a degree of polymerization (DP) higher than 3, and their acidic derivatives with 4-O-methylglucosyluronate or glucosyluronate groups at the non-reducing terminals [2]. 1,3-beta-D- and 1,4-beta-D-galactosyl residues cannot act as substrates. The enzyme can also hydrolyse alpha-L-arabinofuranosidase-treated arabinogalactan protein (AGP) extracted from radish roots [2,3]. AGPs are thought to be involved in many physiological events, such as cell division, cell expansion and cell death [3]." +"3.4.15.6",The enzyme is highly specific for the branched polypeptide cyanophycin and does not hydrolyse poly-L-aspartate or poly-L-arginine [3]. A serine-type exopeptidase that belongs in peptidase family S51. +"3.4.22.67","This enzyme is found in ginger (Zingiber officinale) rhizome and is a member of the papain family. GP-II contains two glycosylation sites. The enzyme is inhibited by some divalent metal ions, such as Hg2+, Cu2+, Cd2+ and Zn2+ [2]. Belongs in peptidase family C1." +"4.1.99.12","Requires a divalent cation, preferably Mg2+, for activity [1]. The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5 [1]. The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin [1]." +"6.1.1.26","In organisms such as Methanosarcina barkeri that incorporate the modified amino acid pyrrolysine (Pyl) into certain methylamine methyltransferases, an unusual tRNAPyl, with a CUA anticodon, can be charged directly with pyrrolysine by this class II aminoacyl---tRNA ligase. The enzyme is specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids [1]." +"6.3.2.29","Requires Mg2+ for activity. Both this enzyme and EC 6.3.2.30, cyanophycin synthase (L-arginine-adding), are required for the elongation of cyanophycin, which is a protein-like cell inclusion that is unique to cyanobacteria and acts as a temporary nitrogen store [2]. Both enzymes are found in the same protein but have different active sites [2,4]. Both L-Asp and L-Arg must be present before either enzyme will display significant activity [2]." +"6.3.2.30","Requires Mg2+ for activity. Both this enzyme and EC 6.3.2.29, cyanophycin synthase (L-aspartate-adding), are required for the elongation of cyanophycin, which is a protein-like cell inclusion that is unique to cyanobacteria and acts as a temporary nitrogen store [2]. Both enzymes are found in the same protein but have different active sites [2,4]. Both L-Asp and L-Arg must be present before either enzyme will display significant activity [2]. Canavanine and lysine can be incoporated into the polymer instead of arginine [2]." +"1.1.1.293","This enzyme along with EC 1.1.1.236, tropinone reductase II, represents a branch point in tropane alkaloid metabolism [3]. Tropine (the product of EC 1.1.1.293) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [3]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [2]." +"2.1.1.161","This enzyme, from the marine cyanobacterium Synechococcus sp. WH8102, differs from EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase in that it cannot use sarcosine as an alternative substrate [1]. Betaine is a 'compatible solute' that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor." +"2.1.1.162","Unlike EC 2.1.1.156 (glycine/sarcosine N-methyltransferase), EC 2.1.1.157 (sarcosine/dimethylglycine N-methyltransferase) and EC 2.1.1.161 (dimethylglycine N-methyltransferase), this enzyme, from the halophilic methanoarchaeon Methanohalophilus portucalensis, can methylate glycine and all of its intermediates to form the compatible solute betaine [1]." +"2.3.1.183","The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2, glutamine synthetase, a key enzyme of nitrogen metabolism in plants [2]." +"2.3.1.184","Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates [1]. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA [1]. S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone [1]." +"3.1.1.81","Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria [5]. N-(3-Oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L-homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates [5]." +"3.5.1.97","Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine lactone ring of AHL-dependent quorum-sensing signal molecules. It has broad specificity for AHLs with side changes ranging in length from 11 to 14 carbons. Substituents at the 3'-position, as found in N-(3-oxododecanoyl)-L-homoserine lactone, do not affect this activity." +"4.2.1.113","Belongs to the enolase superfamily and requires divalent cations, preferably Mg2+ or Mn2+, for activity. Forms part of the vitamin-K-biosynthesis pathway. " +"4.2.2.22","Differs in specificity from EC 4.2.2.9, pectate disaccharide-lyase, as the predominant action is removal of a trisaccharide rather than a disaccharide from the reducing end. Disaccharides and tetrasaccharides may also be removed [2]. " +"5.1.1.18","A pyridoxal-phosphate protein that is highly selective for L-serine as substrate. D-Serine is found in type-II astrocytes in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate (NMDA) receptors [1,2]. The reaction can also occur in the reverse direction but does so more slowly at physiological serine concentrations [4]." +"4.1.2.42","A pyridoxal-phosphate protein that is activated by divalent metal cations (e.g. Co2+, Ni2+, Mn2+ or Mg2+) [1,2]. The reaction is reversible, which can lead to the interconversion of D-threonine and D-allo-threonine [1]. Several other D-beta-hydroxy-alpha-amino acids, such as D-beta-phenylserine, D-beta-hydroxy-alpha-aminovaleric acid and D-beta-3,4-dihydroxyphenylserine, can also act as substrate [1]." +"1.1.1.294","This enzyme carries out the first step in the conversion of chlorophyll b to chlorophyll a. It is involved in chlorophyll degradation, which occurs during leaf senescence [3] and it also forms part of the chlorophyll cycle, which interconverts chlorophyll a and b in response to changing light conditions [4,5]." +"1.3.1.80","Chlorophyll degradation is a characteristic symptom of leaf senescence and fruit ripening. The reaction catalysed by this enzyme requires reduced ferredoxin, which is generated either by NADPH through the pentose-phosphate pathway or by the action of photosystem I [1,2]. This reaction takes place without release of the substrate from EC 1.14.12.20, pheophorbide a oxygenase [3]. Depending on the plant species used as the source of enzyme, one of two possible C-1 epimers of primary fluorescent chlorophyll catabolite (pFCC), pFCC-1 or pFCC-2, is normally formed, with all genera or species within a family producing the same isomer [3,4]. After modification and export, pFCCs are eventually imported into the vacuole, where the acidic environment causes their non-enzymic conversion into colourless breakdown products called non-fluorescent chlorophyll catabolites (NCCs) [2]." +"1.14.12.20","This enzyme catalyses a key reaction in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The enzyme from Arabidopsis contains a Rieske-type iron-sulfur cluster [2] and requires reduced ferredoxin, which is generated either by NADPH through the pentose-phosphate pathway or by the action of photosystem I [4]. While still attached to this enzyme, the product is rapidly converted into primary fluorescent chlorophyll catabolite by the action of EC 1.3.7.12, red chlorophyll catabolite reductase [2,6]. Pheophorbide b acts as an inhibitor. In 18O2 labelling experiments, only the aldehyde oxygen is labelled, suggesting that the other oxygen atom may originate from H2O [1]." +"3.1.1.82","This enzyme forms part of the chlorophyll degradation pathway, and is found in higher plants and in algae. In higher plants it participates in de-greening processes such as fruit ripening, leaf senescence, and flowering. The enzyme exists in two forms: type 1 is induced by senescence whereas type 2 is constitutively expressed [1,2]. The enzyme is highly specific for pheophorbide as substrate (with a preference for pheophorbide a over pheophorbide b) as other chlorophyll derivatives such as protochlorophyllide a, pheophytin a and c, chlorophyll a and b, and chlorophyllide a cannot act as substrates [2]. Another enzyme, called pheophorbide demethoxycarbonylase (PDC), produces pyropheophorbide a from pheophorbide a without forming an intermediate although the precise reaction is not yet known [1]." +"3.4.22.66","Viruses that are members of the Norovirus genus (Caliciviridae family) are a major cause of epidemic acute viral gastroenteritis [4]. The nonstructural proteins of these viruses are produced by proteolytic cleavage of a large precursor polyprotein, performed by a protease that is incorporated into the polyprotein [6]. Cleavage sites are apparently defined by features based on both sequence and structure since several sites in the polyprotein fulfilling the identified sequence requirements are not cleaved [1]. The presence of acidic (Asp), basic (Arg), aromatic (Tyr) or aliphatic (Leu) amino acids at the P1' position results in only minor differences in cleavage efficiency, suggesting that steric or conformational constraints may play a role in determining specificity [1]. Changes to the amino acid at the P2 position do not alter cleavage efficiency [1,2]. Belongs in peptidase family C37." +"4.3.1.22",Forms part of the L-phenylalanine-catabolism pathway in the anoxygenic phototrophic bacterium Rhodobacter sphaeroides OU5. NADPH is oxidized more slowly than NADH. +"5.1.3.23","This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens [1]. The enzyme is highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates [1]." +"1.1.99.32","The product, L-sorbosone, is an intermediate in bacterial 2-keto-L-gulonic-acid formation. The activity of this membrane-bound enzyme is stimulated by Fe(III) or Co2+ but is inhibited by Cu2+. The enzyme is highly specific for L-sorbose as other sugars, such as glucose, mannitol and sorbitol, are not substrates. Phenazine methosulfate and DCIP can act as artificial acceptors." +"2.7.7.65","A GGDEF-domain-containing protein that requires Mg2+ or Mn2+ for activity. The enzyme can be activated by BeF3, a phosphoryl mimic, which results in dimerization [3]. Dimerization is required but is not sufficient for diguanylate-cyclase activity [3]. Cyclic di-3',5'-guanylate is an intracellular signalling molecule that controls motility and adhesion in bacterial cells. It was first identified as having a positive allosteric effect on EC 2.4.1.12, cellulose synthase (UDP-forming) [1]." +"3.1.4.52","Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65, diguanylate cyclase and an allosteric activator of EC 2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive [1]. It is the balance between these two enzymes that determines the cellular level of c-di-GMP [1]." +"3.4.22.68","The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation (epsilon-linked peptide bonds) reactions [1,2,3]. Ulp1 has several functions, including an essential role in chromosomal segregation and progression of the cell cycle through the G2/M phase of the cell cycle. Belongs in peptidase family C48." +"3.4.23.52",An aspartic peptidase from Archaea but not bacteria. In peptidase family A24 (type IV prepilin peptidase family). +"3.5.1.98","A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation [4]. May be identical to EC 3.5.1.17, acyl-lysine deacylase. " +"4.3.1.23","This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase), EC 4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [1]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [3]. The enzyme is far more active with tyrosine than with phenylalanine as substrate, but the substrate specificity can be switched by mutation of a single amino acid (H89F) in the enzyme from the bacterium Rhodobacter sphaeroides [1,2]." +"4.3.1.24","This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase) and EC 4.3.1.23 (tyrosine ammonia-lyase) and EC 4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [9]. The enzyme from some species is highly specific for phenylalanine [7,8]." +"4.3.1.25","This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase), EC 4.3.1.23 (tyrosine ammonia-lyase) and EC 4.3.1.24 (phenylalanine ammonia-lyase). The enzyme from some monocots, including maize, and from the yeast Rhodosporidium toruloides, deaminate L-phenylalanine and L-tyrosine with similar catalytic efficiency [3]. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [4]." +"1.14.13.109","A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine) [1], and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine) [3]. The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene." +"1.14.13.108",A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase [1]. Activity is induced by wounding of the plant tissue [2]. +"1.1.1.295","The rice phytoalexin momilactone A is a diterpenoid secondary metabolite that is involved in the defense mechanism of the plant. Momilactone A is produced in response to attack by a pathogen through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme, which catalyses the last step in the biosynthesis of momilactone A, can use both NAD+ and NADP+ but activity is higher with NAD+ [1]." +"2.2.1.9","Requires Mg2+ for maximal activity. This enzyme is involved in the biosynthesis of vitamin K2 (menaquinone). In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. It had previously been thought that the products of the reaction were (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate (SHCHC), pyruvate and CO2 but it is now known that two separate enzymes are involved: this enzyme and EC 4.2.99.20, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase. Under basic conditions, the product can spontaneously lose pyruvate to form SHCHC." +"1.3.7.6","This enzyme, from a cyanophage infecting oceanic cyanobacteria of the Prochlorococcus genus, uses a four-electron reduction to carry out the reactions catalysed by EC 1.3.7.2 (15,16-dihydrobiliverdin:ferredoxin oxidoreductase) and EC 1.3.7.3 (phycoerythrobilin:ferredoxin oxidoreductase). 15,16-Dihydrobiliverdin is formed as a bound intermediate. Free 15,16-dihydrobiliverdin can also act as a substrate to form phycoerythrobilin." +"1.3.99.24","The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]." +"2.3.1.185",This enzyme exhibits absolute specificity for the 3alpha configuration found in tropine (tropan-3alpha-ol). Pseudotropine (tropan-3beta-ol) is not a substrate [3]. (E)-2-methylcrotonoyl-CoA (tigloyl-CoA) and acetyl-CoA are the best substrates. +"2.3.1.186","This enzyme exhibits absolute specificity for the exo/3beta configuration found in pseudotropine as tropine (tropan-3alpha-ol; see EC 2.3.1.185, tropine acyltransferase) and nortropine are not substrates [1]. Acts on a wide range of aliphatic acyl-CoA derivatives, including acetyl-CoA, beta-methylcrotonyl-CoA and tigloyl-CoA [1]." +"2.6.1.86","Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. In Streptomyces globisporus, the sequential action of this enzyme and EC 1.3.8.16, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity [3,4]." +"2.7.1.161","This archaeal enzyme differs from EC 2.7.1.26, riboflavin kinase, in using CTP as the donor nucleotide. UTP, but not ATP or GTP, can also act as a phosphate donor but it is at least an order of magnitude less efficient than CTP." +"2.7.1.162","This enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway in the probiotic bacterium Bifidobacterium longum. Differs from EC 2.7.1.157, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetylgalactosamine and N-acetylglucosamine at similar rates. Also has some activity with N-acetyl-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity." +"3.2.1.165","Chitosan is a partially or totally N-deacetylated chitin derivative that is found in the cell walls of some phytopathogenic fungi and comprises D-glucosamine residues with a variable content of GlcNAc residues [4]. Acts specifically on chitooligosaccharides and chitosan, having maximal activity on chitotetraose, chitopentaose and their corresponding alcohols [1]. The enzyme can degrade GlcN-GlcNAc but not GlcNAc-GlcNAc [3]. A member of the glycoside hydrolase family 2 (GH-2) [4]." +"4.2.3.28","This class I diterpene cyclase produces ent-cassa-12,15-diene, a precursor of the rice phytoalexins (-)-phytocassanes A-E. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation." +"4.2.3.29","ent-Sandaracopimaradiene is a precursor of the rice oryzalexins A-F. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. As a minor product, this enzyme also forms ent-pimara-8(14),15-diene, which is the sole product of EC 4.2.3.30, ent-pimara-8(14),15-diene synthase. ent-Pimara-8(14),15-diene is not a precursor in the biosynthesis of either gibberellins or phytoalexins [2]." +"4.2.3.30","Unlike EC 4.2.3.29, ent-sandaracopimaradiene synthase, which can produce both ent-sandaracopimaradiene and ent-pimara-8(14),15-diene, this diterpene cyclase produces only ent-pimara-8(14),15-diene. ent-Pimara-8(14),15-diene is not a precursor in the biosynthesis of either gibberellins or phytoalexins." +"4.2.3.31","This enzyme is involved in the biosynthesis of the diterpenoid viguiepinol and requires Mg2+, Co2+, Zn2+ or Ni2+ for activity." +"4.2.3.32","In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides, a structurally unique family of diterpenoids that are highly specific platelet-activating-factor receptor antagonists [1]. Levopimaradiene is widely distributed in higher plants. In some species the enzyme also forms abietadiene, palustradiene, and neoabietadiene [2]." +"4.2.3.33","This diterpene cyclase produces stemar-13-ene, a putative precursor of the rice phytoalexin oryzalexin S. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation." +"4.2.3.34","This enzyme catalyses the committed step in the biosynthesis of the stemodane family of diterpenoid secondary metabolites, some of which possess mild antiviral activity. The enzyme also produces stemod-12-ene and stemar-13-ene as minor products." +"4.2.3.35","This enzyme is a class I terpene synthase [1]. 9beta-Pimara-7,15-diene is a precursor of momilactones A and B, rice diterpenoid phytoalexins that are produced in response to attack (by a pathogen, elicitor or UV irradiation) and are involved in the defense mechanism of the plant. Momilactone B can also act as an allochemical, being constitutively produced in the root of the plant and secreted to the rhizosphere where it suppresses the growth of neighbouring plants and soil microorganisms [1]." +"5.5.1.14","Requires a divalent metal ion, preferably Mg2+, for activity. This class II terpene synthase produces syn-copalyl diphosphate, a precursor of several rice phytoalexins, including oryzalexin S and momilactones A and B. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme is constitutively expressed in the roots of plants where one of its products, momilactone B, acts as an allelochemical (a molecule released into the environment to suppress the growth of neighbouring plants). In other tissues the enzyme is upregulated by conditions that stimulate the biosynthesis of phytoalexins." +"1.1.1.296","This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (-)-isodihydrocarveol." +"1.1.1.297","While the enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate." +"1.3.99.25","This enzyme participates in the carveol and dihydrocarveol degradation pathway of the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme has not been purified, and requires an unknown cofactor, which is different from NAD+, NADP+ or a flavin." +"1.14.13.105","A flavoprotein (FAD). This Baeyer-Villiger monooxygenase enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 has wide substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones [2]. Both (1R,4S)- and (1S,4R)-1-hydroxymenth-8-en-2-one are metabolized, with the lactone product spontaneously rearranging to form 3-isopropenyl-6-oxoheptanoate [1]. " +"2.7.7.66","The delta subunit of malonate decarboxylase serves as an an acyl-carrier protein (ACP) and contains the cofactor 2-(5-triphosphoribosyl)-3-dephospho-CoA. Two reactions are involved in the production of the holo-ACP form of this enzyme. The first reaction is catalysed by EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase. The resulting cofactor is then attached to the ACP subunit via a phosphodiester linkage to a serine residue, thus forming the holo form of the enzyme, in a manner analogous to that of EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase. " +"3.1.1.83","The enzyme catalyses the ring opening of epsilon-lactones which are formed during degradation of dihydrocarveol by the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme also acts on ethyl caproate, indicating that it is an esterase with a preference for lactones (internal cyclic esters). The enzyme is not stereoselective." +"3.1.7.4","Now recognized as two enzymes EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141 sclareol synthase" +"3.5.4.33",The enzyme is involved in editing of tRNA. The active site contains Zn2+ [1]. +"4.2.3.36","Requires Mg2+ for maximal activity but can use Mn2+, Fe2+ or Co2+ to a lesser extent [2]. Following on from EC 5.5.1.15, terpentedienyl-diphosphate synthase, this enzyme completes the transformation of geranylgeranyl diphosphate (GGDP) into terpentetriene, which is a precursor of the diterpenoid antibiotic terpentecin. Farnesyl diphosphate can also act as a substrate." +"4.2.99.20","This enzyme is involved in the biosynthesis of vitamin K2 (menaquinone). In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase, were carried out by a single enzyme but this has since been disproved [2]." +"5.5.1.15","Requires Mg2+. Contains a DXDD motif, which is a characteristic of diterpene cylases whose reactions are initiated by protonation at the 14,15-double bond of geranylgeranyl diphosphate (GGDP) [2]. The triggering proton is lost at the end of the cyclization reaction [3]. The product of the reaction, terpentedienyl diphosphate, is the substrate for EC 4.2.3.36, terpentetriene synthase and is a precursor of the diterpenoid antibiotic terpentecin." +"5.5.1.16","Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol)." +"3.1.4.53","Requires Mg2+ or Mn2+ for activity [2]. This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation [3]." +"1.2.1.73","This reaction is part of a bacterial pathway that can utilize the amino group of taurine as a sole source of nitrogen for growth. At physiological concentrations, NAD+ cannot be replaced by NADP+. The enzyme is specific for sulfoacetaldehyde, as formaldehyde, acetaldehyde, betaine aldehyde, propanal, glyceraldehyde, phosphonoacetaldehyde, glyoxylate, glycolaldehyde and 2-oxobutyrate are not substrates." +"1.3.1.81","NADH cannot replace NADPH as reductant. The Delta8,9-double bond of (+)-cis-isopulegone and the Delta1,2-double bond of (+/-)-piperitone are not substrates. The enzyme from peppermint (Mentha x piperita) converts (+)-pulegone into both (-)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyse the reverse reaction. This enzyme is a member of the medium-chain dehydrogenase/reductase superfamily. " +"1.4.3.21","A group of enzymes that oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, monoamine oxidase, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. In some mammalian tissues the enzyme also functions as a vascular-adhesion protein (VAP-1)." +"1.4.3.22","A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide." +"1.14.13.104","A heme-thiolate protein (P-450). The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan [1]. This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalysed by EC 1.14.13.47, (S)-limonene 3-monooxygenase [1]." +"1.14.19.4","The enzyme, characterized from the protist Euglena gracilis [1] and the microalga Rebecca salina [2], introduces a cis double bond at the 8-position in 20-carbon fatty acids that are incorporated into a glycerolipid and have an existing Delta11 desaturation. The enzyme is a front-end desaturase, introducing the new double bond between the pre-existing double bond and the carboxyl-end of the fatty acid. It contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome. Involved in alternative pathways for the biosynthesis of the polyunsaturated fatty acids arachidonate and icosapentaenoate." +"2.4.1.245","Requires Mg2+ for maximal activity [1]. The enzyme-catalysed reaction is reversible [1]. In the reverse direction to that shown above, the enzyme is specific for alpha,alpha-trehalose as substrate, as it cannot use alpha- or beta-paranitrophenyl glucosides, maltose, sucrose, lactose or cellobiose [1]. While the enzymes from the thermophilic bacterium Rubrobacter xylanophilus and the hyperthermophilic archaeon Pyrococcus horikoshii can use ADP-, UDP- and GDP-alpha-D-glucose to the same extent [2,3], that from the hyperthermophilic archaeon Thermococcus litoralis has a marked preference for ADP-alpha-D-glucose [1] and that from the hyperthermophilic archaeon Thermoproteus tenax has a marked preference for UDP-alpha-D-glucose [4]. " +"3.1.26.12","RNase E is a bacterial ribonuclease that plays a role in the processing of ribosomal RNA (9S to 5S rRNA), the chemical degradation of bulk cellular RNA, the decay of specific regulatory, messenger and structural RNAs and the control of plasmid DNA replication [1]. The enzyme binds to monophosphorylated 5' ends of substrates but exhibits sequential cleavages in the 3' to 5' direction [1]. 2'-O-Methyl nucleotide substitutions at RNase E binding sites do not prevent binding but do prevent cleavage of non-modified target sequences 5' to that locus [1]. In Escherichia coli, the enzyme is found in the RNA degradosome. The C-terminal half of the protein contains binding sites for the three other major degradosomal components, the DEAD-box RNA helicase Rh1B, enolase (EC 4.1.1.11) and polynucleotide phosphorylase (EC 2.7.7.8)." +"3.4.11.24","Aminopeptidases are associated with many biological functions, including protein maturation, protein degradation, cell-cycle control and hormone-level regulation [3,4]. This enzyme contains two zinc molecules in its active site and is activated by Ca2+ [4]. In the presence of Ca2+, the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe [3]. Peptides with proline in the P1' position are not substrates [3]. Belongs in peptidase family M28. " +"1.3.1.82","The reaction occurs in the opposite direction to that shown above. The enzyme participates in the menthol-biosynthesis pathway of Mentha plants. (+)-Pulegone, (+)-cis-isopulegone and (-)-menthone are not substrates. The enzyme has a preference for NADPH as the reductant, with NADH being a poor substitute [2]. The enzyme is highly regioselective for the reduction of the endocyclic 1,2-double bond, and is stereoselective, producing only the 1R-configured product. It is a member of the short-chain dehydrogenase/reductase superfamily." +"1.14.19.5","The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. In moths the enzyme participates in the biosynthesis of their sex pheromones. The enzyme from the marine microalga Thalassiosira pseudonana is specific for palmitoyl-CoA (16:0) [4], that from the leafroller moth Choristoneura rosaceana desaturates myristoyl-CoA (14:0) [5], while that from the moth Spodoptera littoralis accepts both substrates [1]. The enzyme contains three histidine boxes that are conserved in all desaturases [2]. It is membrane-bound, and contains a cytochrome b5-like domain at the N-terminus that serves as the electron donor for the active site of the desaturase." +"1.14.19.6","This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. When acting on 19:1Delta10 fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, towards the methyl-end of the fatty acid. Requires cytochrome b5 as the electron donor [4]." +"1.13.12.15","This enzyme is one of the three enzymes involved in L-dopa (3,4-dihydroxy-L-phenylalanine) catabolism in the non-oxygenic phototrophic bacterium Rubrivivax benzoatilyticus OU5 (and not Rhodobacter sphaeroides OU5 as had been thought [1]), the other two being EC 4.3.1.22 (dihydroxyphenylalanine reductive deaminase) and EC 2.6.1.49 (3,4-dihydroxyphenylalanine transaminase). In addition to L-dopa, the enzyme can also use L-tyrosine, L-phenylalanine, L-tryptophan and glutamate as substrate, but more slowly. The enzyme is inhibited by NADH and 2-oxoglutarate." +"2.1.3.11","This enzyme is specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3, ornithine carbamoyltransferase) or N-acetyl-L-ornithine (see EC 2.1.3.9, N-acetylornithine carbamoyltransferase) as substrate. However, a single amino-acid substitution (Pro90 -> Glu90) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine." +"2.5.1.72","An iron-sulfur protein that requires a [4Fe-4S] cluster for activity [1]. Quinolinate synthase catalyses the second step in the de novo biosynthesis of NAD+ from aspartate in some bacteria, with EC 1.4.3.16 (L-aspartate oxidase) catalysing the first step and EC 2.4.2.19 [nicotinate-nucleotide diphosphorylase (carboxylating)] the third step. In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme [5]." +"3.1.3.78","Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3]." +"3.2.2.26","This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes. " +"3.6.1.53","Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen." +"4.1.2.43","Requires Mg2+ or Mn2+ for maximal activity [1]. The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal [7]. This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase [6]. This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily [5]." +"5.1.99.5","This enzyme, along with N-carbamoylase (EC 3.5.1.77 and EC 3.5.1.87) and hydantoinase, forms part of the reaction cascade known as the ""hydantoinase process"", which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids [7]. The enzyme from Pseudomonas sp. (HyuE) has a preference for hydantoins with aliphatic substituents, e.g. D- and L-5-[2-(methylsulfanyl)ethyl]hydantoin, whereas that from Arthrobacter aurescens shows highest activity with arylalkyl substituents, especially 5-benzylhydantoin, at the 5-position [2]. In the enzyme from Sinorhizobium meliloti, Cys76 is responsible for recognition and proton retrieval of D-isomers, while Cys181 is responsible for L-isomer recognition and racemization [6]." +"5.3.1.27","This enzyme, along with EC 4.1.2.43, 3-hexulose-6-phosphate synthase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of EC 4.1.2.43 (3-hexulose-6-phosphate synthase) and this enzyme [4]." +"2.1.3.10","Derived from the components MadC and MadD of the anaerobic bacterium Malonomonas rubra, this enzyme is a component of EC 7.2.4.4, biotin-dependent malonate decarboxylase. The carboxy group is transferred from malonate to the cofactor of the biotin protein (MadF) with retention of configuration [2]. Similar to EC 4.1.1.87, malonyl-S-ACP decarboxylase, which forms part of the biotin-independent malonate decarboxylase (EC 4.1.1.88), this enzyme also follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetyl-[acyl-carrier protein] [3]." +"2.3.1.187",This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 7.2.4.4). The enzyme can also use acetyl-CoA as a substrate but more slowly [4]. +"2.3.1.277","The enzyme catalyses the first committed step in the biosynthesis of gamma-butyrolactone, as well as 2-alkyl-4-hydroxymethylfuran-3-carboxylate (methylenomycin furan) autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria." +"4.1.1.87","This enzyme comprises the beta and gamma subunits of EC 4.1.1.88, biotin-independent malonate decarboxylase but is not present in EC 7.2.4.4, biotin-dependent malonate decarboxylase. It follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetylated form of the acyl-carrier-protein subunit of malonate decarboxylase [5]. The carboxy group is lost with retention of configuration [3]." +"4.1.1.88","Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. This enzyme is a cytosolic protein that is biotin-independent. The other type is a biotin-dependent, Na+-translocating enzyme that includes both soluble and membrane-bound components (cf. EC 7.2.4.4, biotin-dependent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. In both enzymes, this is achieved by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-ACP. The ACP subunit of both enzymes differs from that found in fatty-acid biosynthesis by having phosphopantethine attached to a serine side-chain as 2-(5-triphosphoribosyl)-3-dephospho-CoA rather than as phosphopantetheine 4'-phosphate. The individual enzymes involved in carrying out the reaction of this enzyme complex are EC 2.3.1.187 (acetyl-S-ACP:malonate ACP transferase), EC 2.3.1.39 ([acyl-carrier-protein] S-malonyltransferase) and EC 4.1.1.87 (malonyl-S-ACP decarboxylase). The carboxy group is lost with retention of configuration [6]. " +"4.1.1.89","Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. The enzyme described here is a biotin-dependent, Na+-translocating enzyme that includes both soluble and membrane-bound components [6]. The other type is a biotin-independent cytosolic protein (cf. EC 4.1.1.88, biotin-independent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. Both enzymes achieve this by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-bound form of the enzyme. The ACP subunit of both enzymes differs from that found in fatty-acid biosynthesis by having phosphopantethine attached to a serine side-chain as 2-(5-triphosphoribosyl)-3-dephospho-CoA rather than as phosphopantetheine 4'-phosphate. In the anaerobic bacterium Malonomonas rubra, the components of the multienzyme complex/enzymes involved in carrying out the reactions of this enzyme are as follows: MadA (EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase), MadB (EC 4.3.99.2, carboxybiotin decarboxylase), MadC/MadD (EC 2.1.3.10, malonyl-S-ACP:biotin-protein carboxyltransferase) and MadH (EC 6.2.1.35, ACP-SH:acetate ligase). Two other components that are involved are MadE, the acyl-carrier protein and MadF, the biotin protein. The carboxy group is lost with retention of configuration [5]. " +"4.3.99.2","The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC 4.1.1.3 (oxaloacetate decarboxylase) and EC 4.1.1.41 (methylmalonyl-CoA decarboxylase) [2]. " +"6.2.1.35","This enzyme, from the anaerobic bacterium Malonomonas rubra, is a component of the multienzyme complex EC 7.2.4.4, biotin-dependent malonate decarboxylase. The enzyme uses the energy from hydrolysis of ATP to convert the thiol group of the acyl-carrier-protein-bound 2'-(5-phosphoribosyl)-3'-dephospho-CoA cofactor into its acetyl thioester [2]." +"1.14.13.106","This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone." +"1.14.21.7","This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product [1,3]. The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation [1]." +"4.2.3.37","Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.15.39, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2]." +"1.3.1.83",This enzyme also acts on geranylgeranyl-chlorophyll a. The reaction occurs in three steps. Which order the three double bonds are reduced is not known. +"4.2.3.43",A multifunctional enzyme with EC 2.5.1.29 farnesyltranstransferase activity. +"4.2.3.41",Requires Mg2+ or less efficiently Mn2+. The enzyme is also able to use farnesyl diphosphate and geranyl diphosphate. +"4.2.3.42","This is a bifunctional enzyme which also has EC 5.5.1.14 syn-copalyl diphosphate synthase activity. Aphidicolan-16beta-ol is a precursor of aphidicolin, a specific inhibitor of DNA polymerase alpha (EC 2.7.7.7)." +"3.1.7.5","Involved in the biosynthesis of plaunotol. There are two isoenzymes with different ion requirements. Neither require Mg2+ but in addition PII is inhibited by Zn2+, Mn2+ and Co2+. It is not known which isoenzyme is involved in plaunotol biosynthesis." +"1.14.13.110",A heme-thiolate protein (P-450). +"1.2.1.74","Abietic acid is the principle component of conifer resin. This enzyme catalyses the last step of the pathway of abietic acid biosynthesis in Abies grandis (grand fir). The activity has been demonstrated in cell-free stem extracts of A. grandis, was present in the cytoplasm, and required NAD+ as cofactor [1]. The enzyme is expressed constitutively at a high level, and is not inducible by wounding of the plant tissue [2]." +"1.1.5.3","This flavin-dependent dehydrogenase is an essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis. In bacteria, the enzyme is localized to the cytoplasmic membrane [6], while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane [2]. In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8, glycerol-3-phosphate dehydrogenase (NAD+), forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD+ by the mitochondrial electron-transport chain [3]. This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix [7,8]. Insect flight muscle uses only CoQ10 as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ9 [4]. The enzyme is activated by calcium [3]." +"1.3.5.2","This Class 2 dihydroorotate dehydrogenase enzyme contains FMN [4]. The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane [2,5,6]. The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides [2,4]. The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates [2]. Methyl-, ethyl-, tert-butyl and benzyl (S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not [2]. Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. " +"3.1.3.79","This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ for activity. Mannosylfructose is the major endogenous osmolyte produced by several alpha-proteobacteria in response to osmotic stress and is synthesized by the sequential action of EC 2.4.1.246 (mannosylfructose-phosphate synthase) followed by this enzyme. While mannosylfructose 6-phosphate is the physiological substrate, the enzyme can use sucrose 6-phosphate very efficiently. The F in mannosylfructose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent." +"2.4.1.246","This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity. GDP-mannose can be replaced by ADP-mannose but with a concomitant decrease in activity. The product of this reaction is dephosphorylated by EC 3.1.3.79 (mannosylfructose-phosphate phosphatase) to form the non-reducing disaccharide mannosylfructose, which is the major endogenous osmolyte produced by several alpha-proteobacteria in response to osmotic stress. The F in the product name is used to indicate that the fructose residue of sucrose carries the substituent." +"1.14.13.107","A flavoprotein (FAD). Limonene is the most widespread terpene and is formed by more than 300 plants. Rhodococcus erythropolis DCL14, a Gram-positive bacterium, is able to grow on both (S)-limonene and (R)-limonene as the sole source of carbon and energy. NADPH can act instead of NADH, although more slowly. It has not been established if the product formed is optically pure or a mixture of two enantiomers." +"1.17.7.1",An iron-sulfur protein found in plant chloroplasts and cyanobacteria that contains a [4Fe-4S] cluster [1]. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis. Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC 1.17.7.3). The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin [1]. +"1.17.7.3",A bacterial iron-sulfur protein that contains a [4Fe-4S] cluster. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria [2]. Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1). +"2.7.7.67","This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1]. " +"2.7.8.41",The eukaryotic enzyme is involved in the biosynthesis of the mitochondrial phospholipid cardiolipin. It requires divalent cations for activity. +"4.2.1.114","This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea. Requires a [4Fe-4S] cluster for activity. In contrast to EC 4.2.1.36, homoaconitate hydratase, this enzyme can catalyse both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate. In addition to cis-homoaconitate, the enzyme can also catalyse the hydration of the physiological substrates dihomoaconitate and trihomoaconitate as well as the non-physiological substrate tetrahomoaconitate. cis-Aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme." +"4.2.1.115","Contains NADP+ as a cofactor. This is the first enzyme in the biosynthetic pathway of pseudaminic acid [3], a sialic-acid-like sugar that is unique to bacteria and is used by Helicobacter pylori to modify its flagellin. This enzyme plays a critical role in H. pylori's pathogenesis, being involved in the synthesis of both functional flagella and lipopolysaccharides [1,2]. It is completely inhibited by UDP-alpha-D-galactose. The reaction results in the chirality of the C-5 atom being inverted. It is thought that Lys-133 acts sequentially as a catalytic acid, protonating the C-6 hydroxy group and as a catalytic base, abstracting the C-5 proton, resulting in the elimination of water. This enzyme belongs to the short-chain dehydrogenase/reductase family of enzymes. " +"4.2.3.38","This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding." +"4.2.3.39","The enzyme is activated by Mg2+ [2]. Similar to many other plant terpenoid synthases, this enzyme produces many products from a single substrate. The predominant product is the cyclic sesquiterpenoid alcohol, 8-epi-cedrol, with minor products including cedrol and the olefins alpha-cedrene, beta-cedrene, (E)-beta-farnesene and (E)-alpha-bisabolene [1]." +"4.2.3.40","This sesquiterpenoid enzyme is constitutively expressed in the root, hydathodes and stigma of the plant Arabidopsis thaliana. If the leaves of the plant are wounded, e.g. by cutting, the enzyme is also induced close to the wound site. The sesquiterpenoids (E)-nerolidol and alpha-bisabolol are also produced by this enzyme as minor products." +"4.2.3.44","The enzyme only gave isopimara-7,15-diene." +"1.5.3.14","As the products of the reaction cannot be converted directly to other polyamines, this class of polyamine oxidases is considered to be involved in the terminal catabolism of polyamines [1]. This enzyme less efficiently catalyses the oxidation of N1-acetylspermine and spermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.15 [N8-acetylspermidine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase). " +"1.5.3.13","The enzyme also catalyses the reaction: N1,N12-diacetylspermine + O2 + H2O = N1-acetylspermidine + 3-acetamamidopropanal + H2O2 [1]. No or very weak activity with spermine, or spermidine in absence of aldehydes. In presence of aldehydes the enzyme catalyses the reactions: 1. spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2, and with weak efficiency 2. spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [2]. A flavoprotein (FAD). This enzyme, encoded by the PAOX gene, is found in mammalian peroxisomes and oxidizes N1-acetylated polyamines at the exo (three-carbon) side of the secondary amine, forming 3-acetamamidopropanal. Since the products of the reactions are deacetylated polyamines, this process is known as polyamine back-conversion. Differs in specificity from EC 1.5.3.14 [polyamine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.15 [N8-acetylspermidine oxidase (propane-1,3-diamine-forming)], EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase). " +"1.5.3.15","Also active with N1-acetylspermine, weak activity with N1,N12-diacetylspermine. No activity with diaminopropane, putrescine, cadaverine, diaminohexane, norspermidine, spermine and spermidine. Absence of monoamine oxidase (EC 1.4.3.4) activity. Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase). " +"1.5.3.16","The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency [3]. The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyses the oxidation of spermine at the exo (three-carbon) side of the tertiary amine. No activity with spermidine. Weak activity with N1-acetylspermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming) and EC 1.5.3.17 (non-specific polyamine oxidase). " +"1.5.3.17","A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [3]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [2]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [1]. +The specific polyamine oxidases are classified as EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 1.5.3.16 (spermine oxidase)." +"1.1.1.298","Catalyses the reduction of malonate semialdehyde to 3-hydroxypropanoate, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively [1,2]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 1.2.1.75 [3]. Different from EC 1.1.1.59 [3-hydroxypropionate dehydrogenase (NAD+)] by cofactor preference." +"1.1.1.299","This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1]. +Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone))." +"1.1.1.300","Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH. " +"1.1.5.4","A flavoprotein (FAD). Vitamin K and several other quinones can act as acceptors. Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.1.299 (malate dehydrogenase [NAD(P)+])." +"1.2.1.75","Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits [3]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298 [3-hydroxypropionate dehydrogenase (NADP+)] [4]." +"1.2.1.76","Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation [1], and in Metallosphaera sedula, where it participates in the 3-hydroxypropanonate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3]." +"1.3.1.84","Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA [2]. Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16. Contains Zn2+." +"1.13.12.16","Previously classified as 2-nitropropane dioxygenase (EC 1.13.11.32), but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Neither hydrogen peroxide nor superoxide were detected during enzyme turnover. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. " +"1.13.12.18","A luciferase from dinoflagellates such as Gonyaulax polyedra, Lingulodinium polyedrum, Noctiluca scintillans, and Pyrocystis lunula. It is a single protein with three luciferase domains. The luciferin is strongly bound by a luciferin binding protein above a pH of 7. " +"1.14.14.7",In Lechevalieria aerocolonigenes the enzyme catalyses the initial step in the biosynthesis of rebeccamycin [2]. +"2.1.1.163","The enzyme catalyses the last step in menaquinone biosynthesis. It is able to accept substrates with varying polyprenyl side chain length (the chain length is determined by polyprenyl diphosphate synthase)[1]. The enzyme from Escherichia coli also catalyses the conversion of 2-methoxy-6-octaprenyl-1,4-benzoquinone to 5-methoxy-2-methyl-3-octaprenyl-1,4-benzoquinone during the biosynthesis of ubiquinone [4]. The enzyme probably acts on menaquinol rather than menaquinone." +"2.3.1.188",p-Coumaroyl-CoA and sinapoyl-CoA also act as substrates. The enzyme is widely distributed in roots of higher plants. +"2.4.1.247","The enzyme from Clostridium phytofermentans is also active towards towards beta-D-galactosyl derivatives of L-mannose, L-lyxose, D-glucose, 2-deoxy-D-glucose, and D-galactose in this order. Differs from 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase (EC 2.4.1.211) in being active towards L-rhamnose and inactive towards N-acetyl hexosamine derivatives." +"2.4.1.248","Specific for (1->6)-alpha-D-glucans (dextrans) and, unlike cyclomaltodextrin glucanotransferase (EC 2.4.1.19), without activity towards (1->4)-alpha-D-glucans, such as amylose. It also has no activity on oligosaccharides, such as amylopectin and pullulan, containing (1->6)-alpha-D-glucosidic linkages at branch points. The enzyme from Bacillus circulans T-3040 has been shown to form cycloisomalto-oligosaccharides of three sizes (7, 8 and 9 glucose units). It will also catalyse the disproportionation of two isomalto-oligosaccharides molecules to yield a series of isomalto-oligosachharides and the addition of D-glucose to cycloisomalto-oligosaccharides with ring opening to form isomalto-oligosaccharides." +"2.4.1.249","Ternatins are a group of polyacetylated delphinidin glucosides that confer +blue color to the petals of Clitoria ternatea (butterfly pea). +This enzyme catalyses two reactions in the biosynthesis of ternatin C5: the conversion of delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside to delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside, followed by the conversion of the later to ternatin C5, by transferring two glucosyl groups in a stepwise manner [1]." +"2.4.2.41","Involved in plant cell wall synthesis. The enzyme from Arabidopsis thaliana also transfers D-xylose from UDP-D-xylose onto oligogalacturonide acceptors. The enzyme did not show significant activity with UDP-glucose, UDP-galactose, or UDP-N-acetyl-D-glucosamine as sugar donors." +"2.5.1.73","In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 (cysteine---tRNA ligase) for the direct Cys-tRNACys formation, Cys-tRNACys is produced by an indirect pathway, in which EC 6.1.1.27 (O-phosphoseryl-tRNA ligase) ligates O-phosphoserine to tRNACys, and EC 2.5.1.73 converts the produced O-phospho-L-seryl-tRNACys to Cys-tRNACys. The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism [1]. Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 (cysteine---tRNA ligase) and the indirect pathway with EC 6.1.1.27 (O-phosphoseryl-tRNA ligase) and EC 2.5.1.73 [2]." +"2.5.1.74","This enzyme catalyses a step in the synthesis of menaquinone, in which the prenyl chain synthesized by polyprenyl diphosphate synthase is transferred to 1,4-dihydroxy-2-naphthoate (DHNA). The bacterial enzyme is an inner membrane protein [1], with the C-terminus located in the periplasm [3]. It is highly specific for DHNA but not for a specific length of the prenyl chain [2]." +"2.5.1.75","Formerly known as tRNA isopentenyltransferase, but it is now known that prenyl diphosphate, rather than isopentenyl diphosphate, is the substrate." +"2.5.1.76","A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65)." +"2.7.1.163","Phosphorylates the antibiotic hygromycin B. Whereas the enzyme from Streptomyces hygroscopicus (EC 2.7.1.119; hygromycin-B 7''-O-kinase) catalyses the formation of 7''-O-phosphohygromycin B, this enzyme, found in Escherichia coli carrying a plasmid conferring resistance to hygromycin-B, forms 4-O-phosphohygromycin B." +"2.7.1.164","In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase)." +"2.9.1.2","A pyridoxal-phosphate protein [4]. In archaea and eukarya selenocysteine formation is achieved by a two-step process: EC 2.7.1.164 (O-phosphoseryl-tRNASec kinase) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase." +"3.1.26.13","Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication. To perform this task the enzyme combines two distinct activities. The polymerase domain (EC 2.7.7.49, RNA-directed DNA polymerase) occupies the N-terminal two-thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third [13,14]. The RNase H domains of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites [15-17]" +"3.2.2.27",Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. EC 3.2.2.27 and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA. +"3.2.2.28","No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N4-ethenocytosine residue [2], significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing E. coli [3]. Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. Uracil-DNA glycosylase (EC 3.2.2.27) and EC 3.2.2.28 form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA." +"3.2.2.29","Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3]." +"3.4.17.23","A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2. " +"3.4.22.69",SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing. In peptidase family C30. +"3.4.22.70",In peptidase family C60. +"3.4.22.71",In peptidase family C60. +"3.4.23.50",In peptidase family A2. +"3.4.23.51",The reaction requires nickel to be bound to the precursor of the large subunit of hydrogenase 3. The endopeptidase uses the metal in the large subunit of [NiFe]-hydrogenases as a recognition motif [1]. In peptidase family A31. +"3.4.24.87",In peptidase family M12. +"3.4.25.2",The HslU subunit of the HslU---HslV complex functions as an ATP dependent 'unfoldase'. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolysed by HslV [5]. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis [7]. In peptidase family T1. +"3.5.1.99","Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia." +"3.5.1.100","In addition (R)-piperidine-3-carboxamide is hydrolysed to (R)-piperidine-3-carboxylic acid and NH3, and (R)-N-tert-butylpiperazine-2-carboxamide is hydrolysed to (R)-piperazine-2-carboxylic acid and tert-butylamine with lower activity. The enzyme does not act on the other amide substrates which are hydrolysed by EC 3.5.1.4 (amidase)." +"3.6.4.12","DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. Some of them unwind duplex DNA with a 3' to 5' polarity [1,3,5,8], others show 5' to 3' polarity [10,11,12,13] or unwind DNA in both directions [14,15]. Some helicases unwind DNA as well as RNA [9,10]. May be identical with EC 3.6.4.13 (RNA helicase). " +"3.6.4.13","RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. Some of them unwind RNA with a 3' to 5' polarity [3], other show 5' to 3' polarity [8]. Some helicases unwind DNA as well as RNA [7,8]. May be identical with EC 3.6.4.12 (DNA helicase)." +"3.7.1.11","Highly specific; does not act on cyclohexanone or cyclohexane-1,3-dione as substrate." +"4.1.1.90","The enzyme can use various vitamin-K derivatives, including menaquinol, but does not contain iron. The mechanism appears to involve the generation of a strong base by oxygenation of vitamin K. It catalyses the post-translational carboxylation of glutamate residues of several proteins of the blood-clotting system. 9--12 glutamate residues are converted to 4-carboxyglutamate (Gla) in a specific domain of the target protein. The 4-pro-S hydrogen of the glutamate residue is removed [5] and there is an inversion of stereochemistry at this position [6]." +"4.1.99.13","A flavoprotein (FAD). The overall repair reaction consists of two distinct steps, one of which is light-independent and the other one light-dependent. In the initial light-independent step, a 6-iminium ion is thought to be generated via proton transfer induced by two histidines highly conserved among the (6-4) photolyases. This intermediate spontaneously rearranges to form an oxetane intermediate by intramolecular nucleophilic attack. In the subsequent light-driven reaction, one electron is believed to be transferred from the fully reduced FAD cofactor (FADH-) to the oxetane intermediate thus forming a neutral FADH radical and an anionic oxetane radical, which spontaneously fractures. The excess electron is then back-transferred to the flavin radical restoring the fully reduced flavin cofactor and a pair of pyrimidine bases [2]." +"4.1.99.14","This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme binds a [4Fe-4S] cluster. The cluster is coordinated by 3 cysteines and an exchangeable SAM molecule [3]. The 5'-deoxy-adenosine radical formed after electron transfer from the [4Fe-4S] cluster to the S-adenosyl-L-methionine, initiates the repair by abstracting the C-6 hydrogen of the spore photoproduct lesion. During the second part of the repair process the SAM molecule is regenerated [3]." +"4.1.99.15","An iron-sulfur protein (contains one [4Fe-4S]2+ per enzyme monomer). The 5'-deoxy-adenosine radical formed after electron transfer from the [4Fe-4S] cluster to the S-adenosyl-L-methionine, initiates the repair by abstracting the C-6 hydrogen of the spore photoproduct lesion. The C–C bond linking the two pyrimidines undergoes fragmentation to give an allyl-type radical. The thermodynamically problematic last step is the transfer of the hydrogen atom back from the 5'-deoxyadenosine to the thymine monomer radical, which completes the repair process [3]. The enzyme from Bacillus subtilis is specific for the (5S)-configured spore photoproduct [4]. For the enzyme from Clostridium acetobutylicum a (5R)-specificity was demonstrated with spore photoproduct in double-helical DNA (cf. EC 4.1.99.14 [R-specific spore photoproduct lyase])." +"4.2.1.116","Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA [2]." +"4.2.1.117","Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates [1]. An iron-sulfur protein." +"4.2.1.118","Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+. " +"4.2.1.119","This enzyme catalyses a hydration step in peroxisomal beta-oxidation. The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units [1]. The enzymes from Aeromonas caviae [4] and Arabidopsis thaliana [5] are monofunctional enzymes. 2-Enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2 [3]." +"4.2.1.120","Contains FAD and a [4Fe-4S] iron-sulfur cluster. The enzyme has been characterized from several microorganisms, including Clostridium kluyveri, where it participates in succinate fermentation [1,2], Clostridium aminobutyricum, where it participates in 4-aminobutyrate degradation [3,4], and Metallosphaera sedula, where it participates in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [5]." +"4.2.3.45",The adjacent gene PaDC2 codes EC 5.5.1.12 copalyl diphosphate synthase. +"4.99.1.8",This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme. +"6.1.1.27","In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 (cysteine---tRNA ligase) for the direct Cys-tRNACys formation, Cys-tRNACys is produced by an indirect pathway, in which EC 6.1.1.27 (O-phosphoseryl-tRNA ligase) ligates O-phosphoserine to tRNACys, and EC 2.5.1.73 (O-phospho-L-seryl-tRNA: Cys-tRNA synthase) converts the produced O-phospho-L-seryl-tRNACys to Cys-tRNACys. The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism [1]. Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 (cysteine---tRNA ligase) and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73 (O-phospho-L-seryl-tRNA: Cys-tRNA synthase) [2]." +"6.2.1.36","Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate." +"6.3.1.13","This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes. Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics. The enzyme may represent a novel target for new classes of antituberculars [2]." +"1.1.5.5","Only described in acetic acid bacteria where it is involved in acetic acid production. Associated with membrane. Electron acceptor is membrane ubiquinone. A model structure suggests that, like all other quinoprotein alcohol dehydrogenases, the catalytic subunit has an 8-bladed β€˜propeller’ structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ; the catalytic subunit also has a heme c in the C-terminal domain. The enzyme has two additional subunits, one of which contains three molecules of heme c. It does not require amines for activation. It has a restricted substrate specificity, oxidizing a few primary alcohols (C2 to C6), but not methanol, secondary alcohols and some aldehydes. It is assayed with phenazine methosulfate or with ferricyanide." +"1.1.1.301",This enzyme participates in arabinitol catabolism. The enzyme also converts D-arabinitol 5-phosphate to D-ribulose 5-phosphate at a lower rate [1]. +"1.1.5.6","The enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups. Formate dehydrogenase-N oxidizes formate in the periplasm, transferring electrons via the menaquinone pool in the cytoplasmic membrane to a dissimilatory nitrate reductase (EC 1.7.5.1), which transfers electrons to nitrate in the cytoplasm. The system generates proton motive force under anaerobic conditions [3]." +"1.1.5.7","This enzyme oxidizes a wide variety of cyclic alcohols. Some minor enzyme activity is found with aliphatic secondary alcohols and sugar alcohols, but not primary alcohols. The enzyme is unable to catalyse the reverse reaction of cyclic ketones or aldehydes to cyclic alcohols. This enzyme differs from EC 1.1.5.5, alcohol dehydrogenase (quinone), which shows activity with ethanol [1]." +"1.1.99.33","Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1]." +"1.2.1.77",This enzyme catalyses a step in the aerobic benzoyl-coenzyme A catabolic pathway in Azoarcus evansii and Burkholderia xenovorans. +"1.4.3.23","Contains a noncovalently bound FAD [1,2]. This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. During catalysis, the bound FAD is reoxidized at the expense of molecular oxygen, producing one molecule of hydrogen peroxide. The enzyme shows significant preference for 7-chloro-L-tryptophan over L-tryptophan [1]." +"1.7.5.1","A membrane-bound enzyme which supports anaerobic respiration on nitrate under anaerobic conditions and in the presence of nitrate. Contains the bicyclic form of the molybdo-bis(molybdopterin guanine dinucleotide) cofactor, iron-sulfur clusters and heme b. Escherichia coli expresses two forms NarA and NarZ, both being comprised of three subunits. " +"1.8.1.16","A dimeric flavoprotein (FAD). The enzyme restores glutathione amide disulfide, which is produced during the reduction of peroxide by EC 1.11.1.17 (glutathione amide-dependent peroxidase), back to glutathione amide (it catalyses the reaction in the opposite direction to that shown). The enzyme belongs to the family of flavoprotein disulfide oxidoreductases, but unlike other members of the family, which are specific for NADPH, it prefers NADH [1]." +"1.11.1.17","This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress [1]. The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase)." +"1.13.12.17","The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P-450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold [1]. Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A [2]. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine [3]." +"1.14.12.21","The enzyme is involved in aerobic benzoate metabolism in Azoarcus evansii. BoxB functions as the oxygenase part of benzoyl-CoA oxygenase in conjunction with BoxA, the reductase component, which upon binding of benzoyl-CoA, transfers two electrons to the ring in the course of dioxygenation. BoxA is a homodimeric 46 kDa iron-sulfur-flavoprotein (FAD), BoxB is a monomeric iron-protein [1]." +"1.14.13.111","A flavoprotein. Methanesulfonate is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Compared with EC 1.14.14.5, alkanesulfonate monooxygenase, this enzyme has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methanesulfonate to butanesulfonate) and excludes all larger molecules, such as arylsulfonates [1]. The enzyme from the bacterium Methylosulfonomonas methylovora is a multicomponent system comprising a hydroxylase, a reductase (MsmD) and a ferredoxin (MsmC). The hydroxylase has both large (MsmA) and small (MsmB) subunits, with each large subunit containing a Rieske-type [2Fe-2S] cluster. cf. EC 1.14.14.34, methanesulfonate monooxygenase (FMNH2)." +"1.14.13.112","This enzyme is involved in brassinosteroid biosynthesis. C-23 hydroxylation shortcuts bypass campestanol, 6-deoxocathasterone, and 6-deoxoteasterone and lead directly from (22S,24R)-22-hydroxy-5alpha-ergostan-3-one and 3-epi-6-deoxocathasterone to 3-dehydro-6-deoxoteasterone and 6-deoxotyphasterol [1]. " +"1.14.15.8","The enzyme from the bacterium Bacillus megaterium hydroxylates a variety of 3-oxo-Delta4-steroids in position 15beta. Ring A-reduced, aromatic, and 3beta-hydroxy-Delta4-steroids do not serve as substrates [2]." +"1.14.99.39","The enzyme catalyses the first reaction in the pathway of ammonia oxidation to nitrite. It contains copper [1], iron [5] and possibly zinc [9]. The enzyme requires two electrons, which are derived indirectly from the quinone pool via a membrane-bound donor." +"2.1.1.164","Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers [1]. The enzyme is a member of the general acid/base-dependent O-methyltransferase family [2]." +"2.1.1.165",This enzyme contributes to the methyl halide emissions from Arabidopsis [6]. +"2.3.1.189","This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium [1]. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs) [2]. The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate [3]." +"2.4.1.250","The enzyme, which belongs to the GT-B fold superfamily, catalyses the first dedicated reaction in the biosynthesis of mycothiol [1]. The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate [2]. A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate [3]." +"2.4.2.42","The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains [2,3]. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein." +"2.7.7.68","This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor, in all methanogenic archaea. cf. EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase and EC 2.7.7.106, 3-phospho-(R)-glycerate guanylyltransferase." +"2.7.8.28","This enzyme is involved in the biosynthesis of factor 420, a redox-active cofactor, in methanogenic archaea and certain bacteria. The specific reaction catalysed in vivo is determined by the availability of substrate, which in turn is determined by the enzyme present in the organism - EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase, EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase, or EC 2.7.7.106, 3-phospho-D-glycerate guanylyltransferase." +"3.1.3.80","This reaction is a shortcut in the Rapoport-Luebering shunt. It bypasses the reactions of EC 5.4.2.11/EC 5.4.2.12 [phosphoglycerate mutases (2,3-diphosphoglycerate-dependent and independent)] and directly forms 2-phospho-D-glycerate by removing the 3-phospho-group of 2,3-diphospho-D-glycerate [1]. The MIPP1 protein also catalyses the reaction of EC 3.1.3.62 (multiple inositol-polyphosphate phosphatase)." +"3.5.1.102","The enzyme catalyses the second step in archaeal riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis. The first step is catalysed by EC 3.5.4.29 (GTP cyclohydrolase IIa). The bacterial enzyme, EC 3.5.4.25 (GTP cyclohydrolase II) catalyses both reactions. " +"3.5.1.103","This enzyme is considered the key enzyme and rate limiting step in the mycothiol biosynthesis pathway [1]. In addition to acetylase activity, the enzyme possesses weak activity of EC 3.5.1.115, mycothiol S-conjugate amidase, and shares sequence similarity with that enzyme [2]. The enzyme requires a divalent transition metal ion for activity, believed to be Zn2+ [3]." +"4.1.2.44","The enzyme is involved in the aerobic benzoyl-CoA catabolic pathway of the bacterium Azoarcus evansii. The enzyme converts 2,3-epoxy-2,3-dihydrobenzoyl-CoA to its oxepin form prior to the ring-opening and the formation of a dialdehyde intermediate." +"4.3.1.26","This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. The enzyme also possesses catalase activity." +"4.3.3.5","This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a glycosylase, and acts in the reverse direction to that shown. It has a wide substrate range, and was shown to glycosylate several substrates, including the staurosporine aglycone, EJG-III-108A, J-104303, 6-N-methyl-arcyriaflavin C and indolo-[2,3-a]-carbazole [1,2]." +"1.1.1.302","The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC 1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate [1]." +"1.1.1.303","The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the yeast Saccharomyces cerevisiae [1,2]. Different from EC 1.1.1.304, diacetyl reductase [(S)-acetoin forming]." +"1.1.1.304","The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae [1-3]. Different from EC 1.1.1.303, diacetyl reductase [(R)-acetoin forming]." +"1.2.1.78",The enzyme is involved in phenanthrene degradation. +"1.4.5.1","An iron-sulfur flavoprotein (FAD). The enzyme from the bacterium Helicobacter pylori is highly specific for D-proline, while the enzyme from the bacterium Escherichia coli B is most active with D-alanine, D-phenylalanine and D-methionine. This enzyme may be the same as EC 1.4.99.6." +"1.5.99.13",A flavoprotein (FAD). The enzyme prefers D-proline and acts on other D-amino acids with lower efficiency. +"1.14.13.113","A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase. " +"1.14.99.40","The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. The other product may be barbituric acid. For a possible mechanism {misc/DMBI}. The stoichiometery of the reaction is not known." +"1.20.4.3",Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. The substrate arseno-mycothiol is formed by EC 2.8.4.2 (arsenate:mycothiol transferase). A second mycothiol recycles mycoredoxin and forms mycothione. +"1.22.1.1",The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN. +"2.3.1.190","Requires thiamine diphosphate. It belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.104, pyruvate dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, and EC 1.4.1.27, glycine cleavage system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). " +"2.5.1.77","Binds a [4Fe-4S] cluster. The cluster is coordinated by 3 cysteines and an exchangeable AdoMet molecule. The first stage of catalysis is reduction of the 2 AdoMet to produce 2 methionine and 2 5'-deoxyadenosin-5-yl radicals that extract a hydrogen from each of the substrates permitting the condensation of the two [1]. The overall reaction catalysed is the transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylaminopyrimidine-2,4(1H,3H)-dione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO). 7,8-Didemethyl-8-hydroxy-5-deazariboflavin is the chromophore of the hydride carrier coenzyme F420 [1]." +"2.5.1.78",Involved in riboflavin biosynthesis. +"2.5.1.79",This plant enzyme is crucial for the proper functioning of xylem vessel elements in the vascular tissues of plants [3]. +"2.5.1.80","This enzyme is more flexible towards the aromatic substrate than EC 2.5.1.34 (4-dimethylallyltryptophan synthase), but similar to that enzyme, accepts only prenyl diphosphate as the prenyl donor." +"2.7.1.165","A key enzyme in the nonphosphorylative Entner-Doudoroff pathway in archaea [1,2]. In the bacterium Hyphomicrobium methylovorum GM2 the enzyme is involved in formaldehyde assimilation I (serine pathway) [5]. In Escherichia coli the enzyme is involved in D-glucarate/D-galactarate degradation [6]. The enzyme requires a divalent metal ion [1]." +"2.8.4.2","Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione." +"3.1.1.84","Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy [2,3]." +"4.1.2.45","This enzyme is involved in naphthalene degradation. The enzyme catalyses a retro-aldol reaction in vitro, and it accepts a broad range of aldehydes and 4-substituted 2-oxobut-3-enoates as substrates [4]." +"5.99.1.4",This enzyme is involved in naphthalene degradation. +"6.3.2.31","This protein catalyses the successive addition of two glutamate residues to factor F420 (coenzyme F420) by two distinct and independent reactions. In the reaction described here the enzyme attaches a glutamate via its alpha-amine group to F420-0. In the second reaction (EC 6.3.2.34, coenzyme F420-1:gamma-L-glutamate ligase) it catalyses the addition of a second L-glutamate residue to the gamma-carboxyl of the first glutamate." +"6.3.2.32",The enzyme caps the gamma-glutamyl tail of the hydride carrier coenzyme F420 [1]. +"6.3.2.33","This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1]." +"6.3.2.34","This protein catalyses the successive addition of two glutamate residues to factor 420 (coenzyme F420) by two distinct and independent reactions. In the first reaction (EC 6.3.2.31, coenzyme F420-0:L-glutamate ligase) the enzyme attaches a glutamate via its alpha-amine group to F420-0. In the second reaction, which is described here, the enzyme catalyses the addition of a second L-glutamate residue to the gamma-carboxyl of the first glutamate." +"1.1.99.34","The enzyme is very specific for D-glucose 6-phosphate. No activity with NAD+, NADP+, flavin adenine dinucleotide and flavin mononucleotide [1]. " +"1.14.13.114",A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid. +"3.5.1.104","Modification of peptidoglycan by N-deacetylation is an important factor in virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis [4-6]. The enzyme from Streptococcus pneumoniae is a metalloenzyme using a His-His-Asp zinc-binding triad with a nearby aspartic acid and histidine acting as the catalytic base and acid, respectively [3]. " +"3.5.1.105","Chitin oligosaccharide deacetylase is a key enzyme in the chitin catabolic cascade of chitinolytic Vibrio strains. Besides being a nutrient, the heterodisaccharide product 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine is a unique inducer of chitinase production in Vibrio parahemolyticus [2]. In contrast to EC 3.5.1.41 (chitin deacetylase) this enzyme is specific for the chitin disaccharide [1,3]. It also deacetylates the chitin trisaccharide with lower efficiency [3]. No activity with higher polymers of GlcNAc [1,3]. " +"3.5.1.106",The reaction is involved in the aerobic catabolism of nicotinic acid. +"3.5.1.107",The reaction is involved in the aerobic catabolism of nicotinic acid. +"1.1.1.305",The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase). +"1.1.1.306","S-hydroxymethylmycothiol is believed to form spontaneously from formaldehyde and mycothiol. This enzyme oxidizes the product of this spontaneous reaction to S-formylmycothiol, in a reaction that is analogous to EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase." +"1.1.2.6","A quinoprotein. The enzyme is involved in bacterial polyvinyl alcohol degradation. Some Gram-negative bacteria degrade polyvinyl alcohol by importing it into the periplasmic space, where it is oxidized by polyvinyl alcohol dehydrogenase, an enzyme that is coupled to the respiratory chain via cytochrome c. The enzyme contains a pyrroloquinoline quinone cofactor." +"1.1.2.7","A periplasmic quinoprotein alcohol dehydrogenase that only occurs in methylotrophic bacteria. It uses the novel specific cytochrome cL as acceptor. Acts on a wide range of primary alcohols, including ethanol, duodecanol, chloroethanol, cinnamyl alcohol, and also formaldehyde. Activity is stimulated by ammonia or methylamine. It is usually assayed with phenazine methosulfate. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ. It differs from EC 1.1.2.8, alcohol dehydrogenase (cytochrome c), in having a high affinity for methanol and in having a second essential small subunit (no known function). " +"1.1.2.8","A periplasmic PQQ-containing quinoprotein. Occurs in Pseudomonas and Rhodopseudomonas. The enzyme from Pseudomonas aeruginosa uses a specific inducible cytochrome c550 as electron acceptor. Acts on a wide range of primary and secondary alcohols, but not methanol. It has a homodimeric structure [contrasting with the heterotetrameric structure of EC 1.1.2.7, methanol dehydrogenase (cytochrome c)]. It is routinely assayed with phenazine methosulfate as electron acceptor. Activity is stimulated by ammonia or amines. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ." +"1.1.98.1","A soluble, periplasmic PQQ-containing quinohemoprotein. Also contains a single heme c. Occurs in Comamonas and Pseudomonas. Does not require an amine activator. Oxidizes a wide range of primary and secondary alcohols, and also aldehydes and large substrates such as sterols; methanol is not a substrate. Usually assayed with phenazine methosulphate or ferricyanide. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed β€˜propeller’ structure, a calcium ion bound to the PQQ in the active site and an unusual disulphide ring structure in close proximity to the PQQ." +"1.1.99.35","Soluble periplasmic enzyme containing a tightly-bound PQQ cofactor that is bound to a calcium ion. As the electron acceptor is not known, the enzyme has been assayed with Wurster's Blue or phenazine methosulfate. It has negligible sequence or structure similarity to other quinoproteins. It catalyses an exceptionally high rate of oxidation of a wide range of aldose sugars, including D-glucose, galactose, arabinose and xylose, and also the disaccharides lactose, cellobiose and maltose. It has been described only in Acinetobacter calcoaceticus." +"1.2.5.1","Flavoprotein (FAD) [1]. This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone [2,3]. Does not accept menaquinone. Activity is greatly enhanced by lipids [4,5,6]. Requires thiamine diphosphate [7]. The enzyme can also form acetoin [8]." +"1.3.5.3","Contains FMN. The enzyme participates in heme b biosynthesis. In the bacterium Escherichia coli it interacts with either ubiquinone or menaquinone, depending on whether the organism grows aerobically or anaerobically." +"1.8.7.2","The enzyme contains a [4Fe-4S] cluster and internal disulfide. It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC 3.1.3.11 (fructose-bisphosphatase), EC 3.1.3.37 (sedoheptulose-bisphosphatase) and EC 2.7.1.19 (phosphoribulokinase) as well as other chloroplast enzymes by disulfide reduction." +"1.11.1.18","Bromoperoxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate. They catalyse the bromination of a range of organic molecules such as sesquiterpenes, forming stable C-Br bonds. Bromoperoxidases also oxidize iodides." +"1.14.11.29","Contains iron, and requires ascorbate. Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia." +"1.14.11.30","Contains iron, and requires ascorbate. Catalyses hydroxylation of an asparagine in the C-terminal transcriptional activation domain of HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which reduces its interaction with the transcriptional coactivator protein p300. The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia. " +"1.14.11.31","Requires Fe2+. Catalyses a step in morphine biosynthesis. The product neopinione spontaneously rearranges to the more stable codeinone. The enzyme also catalyses the 6-O-demethylation of oripavine to morphinone, with lower efficiency. " +"1.14.11.32","Requires Fe2+. Catalyses a step in morphine biosynthesis. The enzyme also catalyses the 3-O-demethylation of thebaine to oripavine, with lower efficiency. " +"1.14.13.115",This P-450 monooxygenase enzyme is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'. +"1.17.2.1","This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases, but differs from most other members of this family. While most members contain an FAD cofactor, the large subunit of this enzyme contains three c-type cytochromes, enabling it to interact with the electron transfer chain, probably by delivering the electrons to a cytochrome oxidase. The small subunit contains a typical molybdopterin cytosine dinucleotide(MCD) cofactor and two [2Fe-2S] clusters [1]." +"2.1.1.166",The enzyme catalyses the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA [3]. +"2.1.2.13",The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305 [UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)]. +"2.3.1.191","The enzyme catalyses a step of lipid A biosynthesis. LpxD from Escherichia coli prefers (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] [3], but it does not have an absolute specificity for 14-carbon hydroxy fatty acids, as it can transfer other fatty acids, including odd-chain fatty acids, if they are available to the organism [5]." +"2.3.1.304","This is the key enzyme in the biosynthesis of polyhydroxyalkanoates (PHA), linear polyesters produced by bacteria as a means of carbon and energy storage [6]. The enzyme catalyses the stereoselective, covalent linkage of (3R)-3-hydroxyacyl-CoA thioesters in a transesterification reaction with concomitant release of coenzyme A. The growing polymer is attached to a conserved active site L-cysteine residue. Three types of PHA synthases have been proposed based on their substrate specificity and enzyme structure. Type I and type III synthases preferentially polymerize short chain hydroxyalkanoate monomers containing 3-5 carbon atoms [1,2]. The difference between these two types is that type I synthases are composed of only a single subunit (PhaC), whereas type III synthases are composed of two different subunits, PhaC and PhaE [3,5]. Type II synthases are also composed of a single subunit (PhaC), but preferentially polymerize monomers containing more than 5 carbon atoms [4]." +"2.3.2.16","The enzyme from Staphylococcus aureus catalyses the transfer of glycine from a charged tRNA to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphosphoundecaprenyl-GlcNAc (lipid II), attaching it to the N6 of the L-Lys at position 3 of the pentapeptide. This is the first step in the synthesis of the pentaglycine interpeptide bridge that is used in S. aureus for the crosslinking of different glycan strands to each other. Four additional Gly residues are subsequently attached by EC 2.3.2.17 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase) and EC 2.3.2.18 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase)." +"2.3.2.17","This enzyme catalyses the successive transfer of two Gly moieties from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc, attaching them to a Gly residue previously attached by EC 2.3.2.16 (lipid II:glycine glycyltransferase) to the N6 of the L-Lys at position 3 of the pentapeptide. This is the second step in the synthesis of the pentaglycine interpeptide bridge that is used by Staphylococcus aureus for the crosslinking of different glycan strands to each other. The next step is catalysed by EC 2.3.2.18 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase). This enzyme is essential for methicillin resistance [1]." +"2.3.2.18","This Staphylococcus aureus enzyme catalyses the successive transfer of two Gly moieties from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N6-tri-Gly)-D-Ala-D-Ala-diphosphoundecaprenyl-GlcNAc, attaching them to the three Gly molecules that were previously attached to the N6 of the L-Lys at position 3 of the pentapeptide by EC 2.3.2.16 (lipid II:glycine glycyltransferase) and EC 2.3.2.17 (N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase). This is the last step in the synthesis of the pentaglycine interpeptide bridge that is used in this organism for the crosslinking of different glycan strands to each other." +"2.4.99.12","The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyse the transfer of a single 3-deoxy-D-manno-oct-2-ulosonate residue from CMP-3-deoxy-D-manno-oct-2-ulosonate to lipid IVA [2-4]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [5]. " +"2.7.7.79","In eukarya an additional guanosine residue is added post-transcriptionally to the 5'-end of tRNAHis molecules. The addition occurs opposite a universally conserved adenosine73 and is thus the result of a non-templated 3'-5' addition reaction. The additional guanosine residue is an important determinant for aminoacylation by EC 6.1.1.21, histidine---tRNA ligase.The enzyme requires a divalent cation for activity [2]. ATP activation is not required when the substrate contains a 5'-triphosphate (ppp-tRNAHis) [3]." +"2.4.99.13",The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.12 [lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [2]. +"2.5.1.154","The corrinoid adenosylation pathway comprises three steps: (i) reduction of Co(III) within the corrinoid to Co(II) by a one-electron transfer. This can occur non-enzymically in the presence of dihydroflavin nucleotides or reduced flavoproteins [1]. (ii) Co(II) is bound by corrinoid adenosyltransferase, resulting in displacement of the lower axial ligand by an aromatic residue. The reduction potential of the 4-coordinate Co(II) intermediate is raised by ~250 mV compared with the free compound, bringing it to within physiological range. This is followed by a second single-electron transfer from either free dihydroflavins or the reduced flavin cofactor of flavoproteins, resulting in reduction to Co(I) [4]. (iii) the Co(I) conducts a nucleophilic attack on the adenosyl moiety of ATP, resulting in transfer of the deoxyadenosyl group and oxidation of the cobalt atom to Co(III) state. Three types of corrinoid adenosyltransferases, not related by sequence, have been described. In the anaerobic bacterium Salmonella enterica they are encoded by the cobA gene (a housekeeping enzyme involved in both the de novo biosynthesis and the salvage of adenosylcobalamin), the pduO gene (involved in (S)-propane-1,2-diol utilization), and the eutT gene (involved in ethanolamine utilization). The first two types, which produce triphosphate, are classified as EC 2.5.1.17, corrinoid adenosyltransferase, while the EutT type hydrolyses triphosphate to diphosphate and phosphate during catalysis and is thus classified separately." +"2.7.7.78","The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose." +"2.4.99.14",The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes. +"2.4.99.15","The enzyme from Chlamydia psittaci transfers four Kdo residues to lipid A, forming a branched tetrasaccharide with the structure alpha-Kdo-(2,8)-[alpha-Kdo-(2,4)]-alpha-Kdo-(2,4)-alpha-Kdo (cf. EC 2.4.99.12 [lipid IVA 3-deoxy-D-manno-octulosonic acid transferase], EC 2.4.99.13 [(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase], and EC 2.4.99.14 [(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase]). " +"2.6.1.87",A pyridoxal 5'-phosphate enzyme. +"2.7.1.166",The enzyme phosphorylates the 4-OH position of Kdo in (Kdo)-lipid IVA. +"2.7.1.167","The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.7.70). The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. The enzyme selectively produces D-glycero-beta-D-manno-heptose 1,7-bisphosphate [5]." +"2.7.1.168","The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in Gram-positive bacteria. The enzyme is specific for the alpha-anomer." +"2.7.7.70","The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.1.167). The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria." +"2.7.7.71","The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. " +"3.1.3.81","The bifunctional enzyme catalyses the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. phosphatidate phosphatase (EC 3.1.3.4)). It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signalling role in stress response [6]. The phosphatase activity of the bifunctional enzyme is Mg2+-independent and N-ethylmaleimide-insensitive and is distinct from the Mg2+-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4 (phosphatidate phosphatase) [5].The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase [4]. " +"3.1.3.82","The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. In vitro the catalytic efficiency with the beta-anomer is 100-200-fold higher than with the alpha-anomer [3]." +"3.1.3.83","The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. The in vitro catalytic efficiency of the enzyme from Bacteroides thetaiotaomicron is 6-fold higher with the alpha-anomer than with the beta-anomer [1]." +"3.5.1.108",A zinc protein. The enzyme catalyses a committed step in the biosynthesis of lipid A. +"3.6.1.54",The enzyme catalyses a step in the biosynthesis of lipid A. +"5.3.1.28","In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein. " +"2.1.1.168",The enzyme catalyses the methylation of uridine2791 of mitochondrial 21S rRNA. +"2.1.1.169","The enzyme from Triticum aestivum catalyses the sequential O-methylation of tricetin via 3'-O-methyltricetin, 3',5'-O-methyltricetin to 3',4',5'-O-trimethyltricetin [2]. " +"2.1.1.170",The enzyme specifically methylates guanine527 at N7 in 16S rRNA. +"2.1.1.171",The enzyme efficiently methylates guanine966 of the assembled 30S subunits in vitro. Protein-free 16S rRNA is not a substrate for RsmD [1]. The enzyme specifically methylates guanine966 at N2 in 16S rRNA. +"2.1.1.172",The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA [1]. The enzyme specifically methylates guanine1207 at N2 in 16S rRNA. +"2.1.1.173","The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate [1]. The enzyme specifically methylates guanine2445 at N2 in 23S rRNA." +"2.1.1.174","The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate [1]. The enzyme specifically methylates guanine1835 at N2 in 23S rRNA. " +"2.4.2.43","Integral membrane protein present in the inner membrane of certain Gram negative endobacteria. In strains that do not produce 3-deoxy-D-manno-octulosonic acid (Kdo), the enzyme adds a single arabinose unit to the 1-phosphate moiety of the tetra-acylated lipid A precursor, lipid IVA. In the presence of a Kdo disaccharide, the enzyme primarily adds an arabinose unit to the 4-phosphate of lipid A molecules. The Salmonella typhimurium enzyme can add arabinose units to both positions." +"2.7.8.29",This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine. +"3.1.7.6",The enzyme is involved in the biosynthesis of acyclic sesquiterpenoids [1]. +"4.2.3.48","The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [2]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants." +"4.2.3.49","The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [1]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants." +"6.3.1.14","This amidase catalyses the last step in the conversion of an L-histidine residue in the translation elongation factor EF2 to diphthamide. This factor is found in all archaea and eukaryota, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36, NAD+---diphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98, diphthine synthase." +"2.7.7.69","This plant enzyme catalyses the conversion of GDP-beta-L-galactose and GDP-alpha-D-glucose to beta-L-galactose 1-phosphate and alpha-D-glucose 1-phosphate, respectively. The enzyme can use inorganic phosphate as the co-substrate, but several hexose 1-phosphates, including alpha-D-mannose 1-phosphate, alpha-D-glucose 1-phosphate, and alpha-D-galactose 1-phosphate, are better guanylyl acceptors. The enzyme's activity on GDP-beta-L-galactose is crucial for the biosynthesis of L-ascorbate." +"1.1.1.307","Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH [cf. EC 1.1.1.431, D-xylose reductase (NADPH)]. However, a few D-xylose reductases, such as those from Neurospora crassa [5], Yamadazyma tenuis [2,3], Scheffersomyces stipitis [1], and the thermophilic fungus Chaetomium thermophilum [4,7], have dual cosubstrate specificity, though they still prefer NADPH to NADH. Very rarely the enzyme prefers NADH [cf. EC 1.1.1.430, D-xylose reductase (NADH)]." +"1.1.99.36","Contains Zn2+. Nicotinoprotein alcohol dehydrogenases are unique medium-chain dehydrogenases/reductases (MDR) alcohol dehydrogenases that have a tightly bound NAD+/NADH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. +The enzyme from the Gram-positive bacterium Amycolatopsis methanolica can accept many primary alcohols as substrates, including benzylalcohol [1]." +"1.1.99.37","Contains Zn2+ and Mg2+. Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis [1-3]. These enzymes are decameric, and possess a 5-fold symmetry [4]. Some of the enzymes can also dismutate formaldehyde to methanol and formate [5]." +"1.14.14.8","This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase." +"2.1.1.175","The enzymes from Oryza sativa (ROMT-15 and ROMT-17) catalyses the stepwise methylation of tricetin to its 3'-mono- and 3',5'-dimethyl ethers. In contrast with the wheat enzyme (EC 2.1.1.169, tricetin 3',4',5'-O-trimethyltransferase), tricetin dimethyl ether is not converted to its 3',4',5'-trimethylated ether derivative [1]. The enzymes from Hordeum vulgare (HvOMT1) and from Zea mays (ZmOMT1) form the 3',5'-dimethyl derivative as the major product [2]." +"2.1.1.176",The enzyme specifically methylates cytosine967 at C5 in 16S rRNA. +"2.1.1.177",YbeA does not methylate uridine at position 1915 [1]. +"2.1.1.178",The enzyme specifically methylates cytosine1407 at C5 in 16S rRNA. +"2.1.1.179","The enzyme from the antibiotic-producing bacterium Micromonospora zionensis specifically methylates guanine1405 at N7 in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins [2]. " +"2.1.1.180",The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N1-methylation at position adenine1408 [4]. +"2.1.1.181","The recombinant YbiN protein is able to methylate partially deproteinized 50 S ribosomal subunit, but neither the completely assembled 50 S subunits nor completely deproteinized 23 S rRNA [1]. " +"2.1.1.182","KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine1518 and adenine1519 in 16S rRNA. Strains lacking the methylase are resistant to kasugamycin [1]." +"2.1.1.183",DIM1 is involved in pre-rRNA processing [1]. +"2.1.1.184",ErmC is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalysing the methylation of 23S rRNA at adenine2085. +"2.1.1.185","The enzyme catalyses the methylation of guanosine2251, a modification conserved in the peptidyltransferase domain of 23S rRNA." +"2.5.1.81","The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. It prefers geranylgeranyl diphosphate and farnesyl diphosphate as allylic substrate [1]. The enzyme from Aeropyrum pernix prefers farnesyl diphosphate as allylic substrate. The enzyme is involved in the biosynthesis of C25-C25 membrane lipids [2]. " +"2.5.1.82",The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate. Requires Mg2+ [1]. +"2.5.1.83",The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate [1]. +"2.5.1.84","(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3]. " +"2.5.1.85",Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate [1]. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains [2]. +"2.5.1.86","The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan [2]. " +"2.5.1.87","The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation [1]. The yeast Saccharomyces cerevisiae has two different enzymes that catalyse this reaction. Rer2p synthesizes a well-defined family of polyprenols of 13--18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits. Largest Srt1p products reach C(290) [2]. The enzyme from Arabidopsis thaliana catalyses the formation of polyprenyl diphosphates with predominant carbon number C(120) [4]." +"2.5.1.88","Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1]. " +"2.5.1.89","This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria. Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate [1]." +"2.7.8.30",The enzyme shows no activity with UDP-4-amino-4-deoxy-beta-L-arabinose. +"6.3.2.35","The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria." +"1.2.1.79","This enzyme participates in the degradation of glutamate and 4-aminobutyrate. +It is similar to EC 1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. The enzyme from Escherichia coli is 20-fold more active with NADP+ than NAD+ [2]." +"1.14.99.41",Contains an Fe2+-4His arrangement. The enzyme is involved in retinal biosynthesis in bacteria [2]. +"2.1.1.187",The enzyme specifically methylates guanine745 at N1 in 23S rRNA. +"2.1.1.188",The enzyme specifically methylates guanine748 at N1 in 23S rRNA. The methyltransferase RlmAII confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae [1]. +"2.1.1.189",The enzyme specifically methylates uracil747 at C5 in 23S rRNA. +"2.1.1.190",The enzyme specifically methylates uracil1939 at C5 in 23S rRNA [1]. The enzyme contains an [4Fe-4S] cluster coordinated by four conserved cysteine residues [2]. +"2.1.1.191",The enzyme specifically methylates cytosine1962 at C5 in 23S rRNA. +"2.1.1.192","Contains an [4Fe-4S] cluster [2]. This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the appended methyl group. RlmN first transfers an CH2 group to a conserved cysteine (Cys355 in Escherichia coli) [6], the generated radical from a second S-adenosyl-L-methionine then attacks the methyl group, exctracting a hydrogen. The formed radical forms a covalent intermediate with the adenine group of the tRNA [9]. RlmN is an endogenous enzyme used by the cell to refine functions of the ribosome in protein synthesis [2]. The enzyme methylates adenosine by a radical mechanism with CH2 from the S-adenosyl-L-methionine and retention of the hydrogen at C-2 of adenosine2503 of 23S rRNA. It will also methylate 8-methyladenosine2503 of 23S rRNA. cf. EC 2.1.1.224 [23S rRNA (adenine2503-C8)-methyltransferase]." +"2.1.1.193",The enzyme specifically methylates uracil1498 at N3 in 16S rRNA. +"2.1.1.194",Contains an [4Fe-S] cluster [1]. Cfr is an plasmid-acquired methyltransferase that protects cells from the action of antibiotics [1]. Cfr methylates position 2 of A2503 after the primary methylation at position 8 is complete [2]. cf. 23S rRNA (adenine2503-C2)-methyltransferase (EC 2.1.1.192). +"2.5.1.90","This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate, the isoprenoid side chain of ubiquinone-8 and menaquinone-8. The enzyme adds five isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry" +"2.5.1.91","This enzyme catalyses the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10. The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry." +"2.5.1.92","This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase]. " +"4.2.3.50","The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-alpha-santalene (EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (see EC 4.2.3.53) as well as (-)-endo-alpha-bergamotene (see EC 4.2.3.54). Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation [1]. " +"4.2.3.51",The enzyme from Solanum lycopersicum has very poor affinity with geranyl diphosphate as substrate. Catalyses the formation of the acyclic myrcene and ocimene as major products in addition to beta-phellandrene [1]. +"4.2.3.52","Requires Mn2+. Mg2+ is not effective [1]. Some (-)-alpha-phellandrene is also formed [3]. The reaction involves a 1,3-hydride shift [4]. " +"4.2.3.53","The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-alpha-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (-)-endo-alpha-bergamotene (see EC 4.2.3.54), as well as (+)-endo-beta-bergamotene. Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation [1]." +"4.2.3.54","The enzyme synthesizes a mixture of sesquiterpenoids from (2Z,6Z)-farnesyl diphosphate. Following dephosphorylation of (2Z,6Z)-farnesyl diphosphate, the (2Z,6Z)-farnesyl carbocation is converted to either the (6R)- or the (6S)-bisabolyl cations depending on the stereochemistry of the 6,1 closure. The (6R)-bisabolyl cation will then lead to the formation of (+)-alpha-santalene (see EC 4.2.3.50), while the (6S)-bisabolyl cation will give rise to (+)-endo-beta-bergamotene (EC 4.2.3.53) as well as (-)-endo-alpha-bergamotene. Small amounts of (-)-epi-beta-santalene are also formed from the (6R)-bisabolyl cation and small amounts of (-)-exo-alpha-bergamotene are formed from the (6S)-bisabolyl cation [1]." +"6.1.2.1","The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria." +"2.5.1.95","Involved in the biosynthesis of the polysaccharide xanthan. 30-40% of the terminal mannose residues of xanthan have a 4,6-O-(1-carboxyethan-1,1-diyl) ketal group. It also acts on the 6-O-acetyl derivative of the inner mannose unit." +"2.7.7.77",Catalyses the guanylation of the molybdenum cofactor. This modification occurs only in prokaryotes. +"2.7.8.33","This enzyme catalyses the synthesis of N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. The enzyme also initiates the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide in certain Escherichia coli strains, including K-12 [2] and of teichoic acid in certain Gram-positive bacteria [4]." +"1.1.5.8","The enzyme is membrane-bound. Does not use NAD(P)+ as acceptor. Contains pyrroloquinoline-quinone. cf. EC 1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+], and EC 1.1.1.25, shikimate dehydrogenase (NADP+)." +"1.3.5.4","The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, succinate dehydrogenase (quinone), to which it is closely related." +"1.3.8.10","Contains FAD. The enzyme, characterized from the strict anaerobic bacterium Syntrophus aciditrophicus, is involved in production of cyclohexane-1-carboxylate, a byproduct produced by that organism during fermentation of benzoate and crotonate to acetate." +"1.14.12.22","This enzyme catalyses the first reaction in the pathway of carbazole degradation. The enzyme attacks at the 1 and 9a positions of carbazole, resulting in the formation of a highly unstable hemiaminal intermediate that undergoes a spontaneous cleavage and rearomatization, resulting in 2'-aminobiphenyl-2,3-diol. In most bacteria the enzyme is a complex composed of a terminal oxygenase, a ferredoxin, and a ferredoxin reductase. The terminal oxygenase component contains a nonheme iron centre and a Rieske [2Fe-2S] iron-sulfur cluster." +"1.14.13.116",Contains cytochrome P-450. +"1.14.13.117","A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-isoleucine, the first committed steps in the biosynthesis of the cyanogenic glucoside lotaustralin in the plant Lotus japonicus. The product of the two hydroxylations, N,N-dihydroxy-L-isoleucine, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The product, (E)-2-methylbutanal oxime, undergoes a spontaneous isomerization to the (Z) form. The enzyme can also accept L-valine as substrate, with a lower activity. It is different from EC 1.14.13.118 (valine N-monooxygenase), which prefers L-valine." +"1.14.13.118","A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-valine, the first committed steps in the biosynthesis of the cyanogenic glucoside linamarin in Manihot esculenta (cassava). The product of the two hydroxylations, N,N-dihydroxy-L-valine, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The product, (E)-2-methylpropanal oxime, undergoes a spontaneous isomerization to the (Z) form. The enzyme can also accept L-isoleucine as substrate, with a lower activity. It is different from EC 1.14.13.117 (isoleucine N-monooxygenase), which prefers L-isoleucine." +"1.17.5.2","This enzyme, characterized from the soil bacterium Pseudomonas sp. CBB1, catalyses the incorporation of an oxygen atom originating from a water molecule into position C-8 of caffeine. It can also use theobromine as substrate. The enzyme utilizes short-tail ubiquinones as the preferred electron acceptor. " +"2.1.1.195","This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis. See EC 2.1.1.152, precorrin-6A synthase (deacetylating), for the C1-methyltransferase that participates in the aerobic cobalamin biosynthesis pathway." +"2.1.1.196","This enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-6B. The equivalent activity in the aerobic adenosylcobalamin biosynthesis pathway is catalysed by the bifunctional enzyme EC 2.1.1.132, precorrin-6B C5,15-methyltransferase (decarboxylating)." +"2.1.1.197","Involved in an early step of biotin biosynthesis in Gram-negative bacteria. This enzyme catalyses the transfer of a methyl group to the omega-carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester. The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl-[acyl-carrier-protein] methyl ester [5]. While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein] [6]" +"2.1.1.198",RsmI catalyses the 2'-O-methylation of cytidine1402 and RsmH (EC 2.1.1.199) catalyses the N4-methylation of cytidine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons. +"2.1.1.199",RsmH catalyses the N4-methylation of cytosine1402 and RsmI (EC 2.1.1.198) catalyses the 2'-O-methylation of cytosine1402 in 16S rRNA. Both methylations are necessary for efficient translation initiation at the UUG and GUG codons. +"2.3.1.192","Not identical with EC 2.3.1.13 (glycine N-acyltransferase). +This enzyme was purified from bovine liver mitochondria. L-asparagine, L-glutamine and L-arginine are alternative substrates to glycine, but have higher Km values. " +"2.5.1.93",The enzyme is involved in shikonin biosynthesis. It has a strict substrate specificity for geranyl diphosphate and an absolute requirement for Mg2+ [2]. +"2.8.2.35","The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) [1]." +"3.1.2.28","This enzyme participates in the synthesis of menaquinones [4], phylloquinone [3], as well as several plant pigments [1,2]. The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 does not accept benzoyl-CoA or phenylacetyl-CoA as substrates [3]." +"3.2.1.166","Heparanase cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group [2]. Heparanase-1 cuts macromolecular heparin into fragments of 5000--20000 Da [5]. The enzyme cleaves the heparan sulfate glycosaminoglycans from proteoglycan core proteins and degrades them to small oligosaccharides. Inside cells, the enzyme is important for the normal catabolism of heparan sulfate proteoglycans, generating glycosaminoglycan fragments that are then transported to lysosomes and completely degraded. When secreted, heparanase degrades basement membrane heparan sulfate glycosaminoglycans at sites of injury or inflammation, allowing extravasion of immune cells into nonvascular spaces and releasing factors that regulate cell proliferation and angiogenesis [1]." +"3.7.1.12",This enzyme hydrolyses the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde. This is a key reaction in the contraction of the porphyrin-type tetrapyrrole ring and its conversion to a corrin ring in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway. +"3.7.1.13",This enzyme catalyses the third step in the aerobic degradation pathway of carbazole. The effect of the presence of an amino group or hydroxyl group at the 2-position of the substrate is small. The enzyme has no cofactor requirement [2]. +"1.1.1.308","The enzyme is involved in degradation of (R)-2,3-dihydroxypropanesulfonate. " +"1.1.1.309","The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate. The preferred cofactor is NADH, lower activity with NADPH [1]. " +"1.2.1.80","Catalyses the reaction in the opposite direction. This enzyme, purified from the cyanobacterium Synechococcus elongatus PCC 7942, catalyses the NAD(P)H-dependent reduction of an activated fatty acid (acyl-[acp]) to the corresponding aldehyde. Together with EC 4.1.99.5, octadecanal decarbonylase, it is involved in alkane biosynthesis. The natural substrates of the enzyme are C16 and C18 activated fatty acids. Requires Mg2+." +"1.3.1.85","The reaction is catalysed in the reverse direction. This enzyme, isolated from the bacterium Rhodobacter sphaeroides, catalyses (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the presence of CO2. When CO2 is absent, the enzyme catalyses the reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity (relative to (E)-but-2-enoyl-CoA carboxylation)." +"1.3.1.86","Catalyses the reaction in the reverse direction. This enzyme from Streptomyces collinus is specific for (E)-but-2-enoyl-CoA, and is proposed to provide butanoyl-CoA as a starter unit for straight-chain fatty acid biosynthesis." +"1.11.1.19","Heme proteins with proximal histidine secreted by basidiomycetous fungi and eubacteria. They are similar to EC 1.11.1.16 versatile peroxidase (oxidation of Reactive Black 5, phenols, veratryl alcohol), but differ from the latter in their ability to efficiently oxidize a number of recalcitrant anthraquinone dyes, and inability to oxidize Mn(II). The model substrate Reactive Blue 5 is converted with high efficiency via a so far unique mechanism that combines oxidative and hydrolytic steps and leads to the formation of phthalic acid. Bacterial TfuDyP catalyses sulfoxidation." +"1.11.2.1","A heme-thiolate protein (P-450). Enzymes of this type include glycoproteins secreted by agaric basidiomycetes. They catalyse the insertion of an oxygen atom from H2O2 into a wide variety of substrates, including aromatic rings such as naphthalene, toluene, phenanthrene, pyrene and p-nitrophenol, recalcitrant heterocycles such as pyridine, dibenzofuran, various ethers (resulting in O-dealkylation) and alkanes such as propane, hexane and cyclohexane. Reactions catalysed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, O- and N-dealkylation, bromination and one-electron oxidations. They have little or no activity toward chloride. Mechanistically, the catalytic cycle of unspecific (mono)-peroxygenases combines elements of the ""shunt"" pathway of cytochrome P-450s (a side activity that utilizes a peroxide in place of dioxygen and NAD[P]H) and the classic heme peroxidase cycle." +"2.4.1.251",The enzyme is involved in the biosynthesis of the exopolysaccharide xanthan. +"2.4.1.252",In the bacterium Gluconacetobacter xylinus (previously known as Acetobacter xylinum) the enzyme is involved in the biosynthesis of the exopolysaccharide acetan [1]. In Xanthomonas campestris the enzyme is involved in the biosynthesis of the exopolysaccharide xanthan [5]. +"2.4.1.253","The enzyme is specific for UDP-D-glucuronate as a sugar donor and flavones with substitution ortho- to the 7-OH group such as baicalein (6-OH), scutellarein (6-OH) and wogonin (8-OMe). " +"2.5.1.94","This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride." +"2.7.1.169","The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine." +"2.7.4.25","The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP), using ATP as the preferred phosphoryl donor. Unlike EC 2.7.4.14, a eukaryotic enzyme that phosphorylates UMP and CMP with similar efficiency, the prokaryotic enzyme phosphorylates UMP with very low rates, and this function is catalysed in prokaryotes by EC 2.7.4.22, UMP kinase. The enzyme phosphorylates dCMP nearly as well as it does CMP [1]." +"2.7.8.31",The enzyme is involved in biosynthesis of xanthan. +"3.2.1.167",The enzyme also hydrolyses wogonin 7-O-beta-D-glucuronide and oroxylin 7-O-beta-D-glucuronide with lower efficiency [4]. Neglegible activity with p-nitrophenyl-beta-D-glucuronide [2]. +"3.2.1.168",The enzyme exhibits high specificity towards 7-O-linked flavonoid beta-rutinosides. +"3.5.2.19","The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2]. " +"3.5.99.8",The enzyme catalyses the initial step in biodegradation of 5-nitroanthranilic acid by Bradyrhizobium sp. strain JS329. +"4.1.2.46","The enzyme contains Zn2+ [1]. The enzyme catalyses the stereoselective synthesis of aliphatic (R)-cyanohydrins [1]. No activity towards mandelonitrile and 4-hydroxymandelonitrile [5]. Natural substrates for the (R)-oxynitrilase from Linum usitatissimum are acetone and butan-2-one, which are the building blocks of the cyanogen glycosides in Linum, linamarin and lotaustralin, or linustatin and neolinustatin, respectively [4]. " +"4.1.2.47","Hydroxynitrile lyases catalyses the the cleavage of hydroxynitriles into cyanide and the corresponding aldehyde or ketone. In nature the liberation of cyanide serves as a defense mechanism against herbivores and microbial attack in plants. In vitro the enzymes from Manihot esculenta and Hevea brasiliensis accept a broad range of aliphatic and aromatic carbonyl compounds as substrates and catalyse the formation of (S)-hydroxynitriles [1,10]." +"4.1.3.41","A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans IFO 13301, is strictly D-specific as to the alpha-position of the substrate, but accepts both the threo and erythro forms at the beta-position. The erythro form is a far better substrate (about 100-fold). The enzyme can also accept D-allothreonine, D-threonine, erythro-3-phenyl-D-serine and threo-3-phenyl-D-serine. Different from EC 4.1.3.14, erythro-3-hydroxy-L-aspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+." +"4.2.1.121","A heme-thiolate protein (P-450) [2]. It catalyses the selective removal of pro-R hydrogen at C-8 in the biosynthesis of colneleic acid [4]. It forms also (8E)-9-[(1E,3Z,6Z)-nona-1,3,6-trien-1-yloxy]non-8-enoic acid (i.e. colnelenate) from (9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate. The corresponding 13-hydroperoxides are poor substrates [1,3]. The divinyl ethers colneleate and colnelenate have antimicrobial activity. " +"4.3.1.27","A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Delftia sp. HT23, also has activity against L-threo-3-hydroxyaspartate, L-erythro-3-hydroxyaspartate, and D-serine. Different from EC 4.3.1.20, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.16, threo-3-hydroxy-L-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Co2+ or Ni2+." +"6.3.2.36","The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 [pantoate---beta-alanine ligase] and EC 2.7.1.33 [pantothenate kinase], respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine. The two archaeal enzymes that catalyse this conversion are EC 2.7.1.169, pantoate kinase, and this enzyme." +"1.1.1.310","This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 1.1.1.338, (2R)-3-sulfolactate dehydrogenase (NADP+), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24, (2R)-sulfolactate sulfo-lyase. +The enzyme is specific for NAD+. " +"1.1.1.311",The enzyme is involved in degradation of ethylbenzene. +"1.1.98.2","The enzyme is very specific for D-glucose 6-phosphate. No activity with NAD+, NADP+, FAD and FMN [1]." +"1.3.7.7","Occurs in photosynthetic bacteria, cyanobacteria, green algae and gymnosperms. The enzyme catalyses trans-reduction of the D-ring of protochlorophyllide; the product has the (7S,8S)-configuration. Unlike EC 1.3.1.33 (protochlorophyllide reductase), light is not required. The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of nitrogenase (EC 1.18.6.1), which catalyses an ATP-driven reduction." +"1.5.3.18",The enzyme is involved in pipecolic acid biosynthesis. A flavoprotein (FAD). +"1.6.5.8","An iron-sulfur flavoprotein, containing two covalently bound molecules of FMN, one noncovalently bound FAD, one riboflavin, and one [2Fe-2S] cluster." +"1.11.1.20","The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2." +"1.11.2.2","Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene." +"1.11.2.3","A heme protein with calcium binding motif (caleosin-type). Enzymes of this type include membrane-bound proteins found in seeds of different plants. They catalyse the direct transfer of one oxygen atom from an organic hydroperoxide, which is reduced into its corresponding alcohol to a substrate which will be oxidized. Reactions catalysed include hydroxylation, epoxidation and sulfoxidation. Preferred substrate and co-substrate are unsaturated fatty acids and fatty acid hydroperoxides, respectively. Plant seed peroxygenase is involved in the synthesis of cutin." +"1.11.2.4","A cytosolic heme-thiolate protein with sequence homology to P-450 monooxygenases. Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function. Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis). Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalysed by the common P-450s. A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated. Oxidizes the peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction." +"1.14.13.119",A heme-thiolate protein (P-450). Kinetic studies suggest that 1beta-hydroxyepiaristolochene is mainly formed first followed by hydroxylation at C-3. However the reverse order via 3alpha-hydroxyepiaristolochene does occur. +"1.14.13.120","A heme-thiolate protein (P-450). The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien-12-oate to give 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which probably spontaneously cyclises to form the lactone ring." +"1.14.13.121","A heme-thiolate protein (P-450). The enzyme from the plant Hyoscymus muticus also hydroxylates valencene at C-2 to give the alpha-hydroxy compound, nootkatol, and this is converted into nootkatone. 5-Epiaristolochene and epieremophilene are hydroxylated at C-2 to give a 2beta-hydroxy derivative which is not further oxidized." +"1.14.21.8","A heme-thiolate enzyme (P-450) catalysing an oxidative reaction that does not incorporate oxygen into the product. Catalyses a step in the biosynthesis of (-)-maackiain, the main pterocarpan phytoalexin in chickpea (Cicer arietinum)." +"2.1.1.200",In Escherichia coli YfhQ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine32 in tRNA. No methylation of cytosine34 in tRNALeu(CAA). In vitro the enzyme 2-O-methylates cytidine32 of tRNASer1 and uridine32 of tRNAGln2. +"2.1.1.201","This enzyme is involved in ubiquinone biosynthesis. Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone-9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units. For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant [3]. The bifunctional enzyme from Escherichia coli also catalyses the methylation of demethylmenaquinol-8 (this activity is classified as EC 2.1.1.163) [1]. " +"2.1.1.202","The enzyme from Saccharomyces cerevisiae is responsible for complete 5-methylcytosine methylations of yeast tRNA. The incidence of modification depends on the cytosine position in tRNA. At positions 34 and 40, 5-methylcytosine is found only in two yeast tRNAs (tRNALeu(CUA) and tRNAPhe(GAA), respectively), whereas most other elongator yeast tRNAs bear either 5-methylcytosine48 or 5-methylcytosine49, but never both in the same tRNA molecule [1]. The formation of 5-methylcytosine34 and 5-methylcytosine40 is a strictly intron-dependent process, whereas the formation of 5-methylcytosine48 and 5-methylcytosine49 is an intron-independent process [2,3]. " +"2.1.1.203",The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors. The intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors [1]. +"2.1.1.204","The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3]. " +"2.1.1.205","The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe, tRNATrp and, possibly, tRNALeu." +"2.1.1.206",The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts. +"2.3.1.193","The enzyme acetylates the wobble base cytidine34 of the CAU anticodon of elongation-specific tRNAMet. Escherichia coli TmcA strictly discriminates elongator tRNAMet from tRNAIle, which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem. The enzyme can use GTP in place of ATP for formation of N4-acetylcytidine [1]. " +"2.3.1.194","The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway. +Unlike the homologous EC 2.3.1.180 (beta-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate." +"2.3.1.195","The enzyme is resonsible for the production of (3Z)-hex-3-en-1-yl acetate, the major volatile compound released upon mechanical wounding of the leaves of Arabidopsis thaliana [1]." +"2.4.1.254",The enzyme is highly specific for cyanidin 3-O-glucosides and UDP-alpha-D-glucuronate. Involved in the production of glucuronosylated anthocyanins that are the origin of the red coloration of flowers of Bellis perennis [1]. +"2.4.1.255","Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins. " +"2.7.7.73","Binds Zn2+. The enzyme catalyses the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of thiamine. +The enzyme shows significant structural similarity to ubiquitin-activating enzyme [3,4]. In Escherichia coli, but not in Bacillus subtilis, the enzyme forms a cross link from Cys-184 to the ThiS carboxy terminus (the position that is also thiolated) via an acyldisulfide [2]." +"2.7.8.32",Mn2+ required for activity. The enzyme is specific for mannose as an acceptor but is flexible as to the structural context of the mannosyl disaccharide. +"3.1.7.7",Isolated from the plants Valeriana officinalis (valerian) and Persicaria hydropiper (water pepper). The enzyme does not act on farnesol or drimenol diphosphate. Using 18-oxygen labelled water 18-oxygen was incorporated suggesting involvement of a stabilised carbocation or an equivalent species. +"3.2.1.169","Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins." +"4.2.3.55","The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene. The second step is the isomerization to (S)-beta-macrocarpene (cf. EC 5.5.1.17, (S)-beta-macrocarpene synthase). The enzyme requires Mg2+ or Mn2+ for activity." +"4.2.3.57","Widely distributed in higher plants, cf. EC 4.2.3.89 (+)-beta-caryophyllene synthase." +"4.2.3.58","As well as 61% longifolene the enzyme gives 15% of alpha-longipinene, 6% longicyclene and traces of other sesquiterpenoids." +"5.4.99.19","The enzyme is specific for uridine516 in 16S rRNA. In vitro, the enzyme does not modify free 16S rRNA. The preferred substrate is a 5'-terminal fragment of 16S rRNA complexed with 30S ribosomal proteins [1]." +"5.4.99.20",The enzyme modifies uridine2457 in a stem of 23S RNA in Escherichia coli. +"5.4.99.21","The enzyme is not completely specific for uridine2604 and can, to a small extent, also react with uridine2605 [1]. " +"5.4.99.22",Pseudouridine synthase RluB converts uridine2605 of 23S rRNA to pseudouridine. +"5.4.99.23","Pseudouridine synthase RluD converts uridines at positions 1911, 1915, and 1917 of 23S rRNA to pseudouridines. These nucleotides are located in the functionally important helix-loop 69 of 23S rRNA [1]. " +"5.4.99.24","The enzyme converts uridines at position 955, 2504 and 2580 of 23S rRNA to pseudouridines." +"5.4.99.25","Pseudouridine synthase TruB from Escherichia coli specifically modifies uridine55 in tRNA molecules [1]. The bifunctional archaeal enzyme also catalyses the pseudouridylation of uridine54 [6]. It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in Escherichia coli tRNAs by thymine." +"5.4.99.26",TruC specifically modifies uridines at positions 65 in tRNA. +"5.4.99.27","Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA [2,3]. The Pus7 protein from Saccharomyces cerevisiae is a multisite-multisubstrate pseudouridine synthase that is able to modify uridine13 in several yeast tRNAs, uridine35 in the pre-tRNATyr, uridine35 in U2 small nuclear RNA, and uridine50 in 5S rRNA [5]." +"5.4.99.28",The dual-specificity enzyme from Escherichia coli also catalyses the formation of pseudouridine746 in 23S rRNA [5]. cf. EC 5.4.99.29 (23S rRNA pseudouridine746 synthase). +"5.4.99.29",RluA is the sole protein responsible for the in vivo formation of 23S RNA pseudouridine746 [2]. The dual-specificity enzyme also catalyses the formation of uridine32 in tRNA [3]. cf. EC 5.4.99.28 (tRNA pseudouridine32 synthase). +"5.4.99.30",The reaction is reversible and at thermodynamic equilibrium the pyranose form is favored over the furanose form (90:10) [1]. +"5.5.1.17","The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene (cf. EC 4.2.3.55, (S)-beta-bisabolene synthase). The second step is the isomerization to (S)-beta-macrocarpene." +"1.7.2.4","The reaction is observed only in the direction of nitrous oxide reduction. Contains the mixed-valent dinuclear CuA species at the electron entry site of the enzyme, and the tetranuclear Cu-Z centre in the active site. +In Paracoccus pantotrophus, the electron donor is cytochrome c552." +"1.8.5.3","The enzyme participates in bacterial electron transfer pathways in which dimethylsulfoxide (DMSO) is the terminal electron acceptor. It is composed of three subunits - DmsA contains a bis(guanylyl molybdopterin) cofactor and a [4Fe-4S] cluster, DmsB is an iron-sulfur protein, and DmsC is a transmembrane protein that anchors the enzyme and accepts electrons from the quinol pool. The electrons are passed through DmsB to DmsA and on to DMSO. The enzyme can also reduce pyridine-N-oxide and trimethylamine N-oxide to the corresponding amines with lower activity." +"1.14.13.122","Chlorophyll b is required for the assembly of stable light-harvesting complexes (LHCs) in the chloroplast of green algae, cyanobacteria and plants [2,3]. Contains a mononuclear iron centre [3]. The enzyme catalyses two successive hydroxylations at the 7-methyl group of chlorophyllide a. The second step yields the aldehyde hydrate, which loses H2O spontaneously to form chlorophyllide b [2]. Chlorophyll a and protochlorophyllide a are not substrates [2]." +"2.4.1.256","This eukaryotic enzyme performs the final step in the synthesis of the lipid-linked oligosaccharide, attaching D-glucose in an alpha-1,2-linkage to the outermost D-glucose in the long branch. The lipid-linked oligosaccharide is involved in N-linked protein glycosylation of selected asparagine residues of nascent polypeptide chains in eukaryotic cells." +"2.4.1.257","The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha1,3-mannosylation (cf. EC 2.4.1.132) of beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol, followed by an alpha1,6-mannosylation, to form the first branched pentasaccharide intermediate of the dolichol pathway [1,2]. " +"2.4.1.258","The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate. The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalysed by ALG3. " +"2.4.1.259","The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate. ALG9 mannosyltransferase catalyses the addition of two different alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to Man6GlcNAc2-PP-Dol (EC 2.4.1.259) and the addition of alpha-1,2-mannose to Man8GlcNAc2-PP-Dol (EC 2.4.1.261). " +"2.4.1.260","The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate. " +"2.4.1.261","The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate. ALG9 mannosyltransferase catalyses the addition of two different alpha-1,2-mannose residues: the addition of alpha-1,2-mannose to Man6GlcNAc2-PP-Dol (EC 2.4.1.259) and the addition of alpha-1,2-mannose to Man8GlcNAc2-PP-Dol (EC 2.4.1.261). " +"3.1.2.29","Fluoroacetate is extremely toxic. It reacts with CoA to form fluoroacetyl-CoA, which substitutes for acetyl CoA and reacts with EC 2.3.3.1 (citrate synthase) to produce fluorocitrate, a metabolite of which binds very tightly to EC 4.2.1.3 (aconitase) and halts the TCA cycle. This enzyme hydrolyses fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance on the organisms that produce it. It has been described in the poisonous plant Dichapetalum cymosum and the bacterium Streptomyces cattleya, both of which are fluoroacetate producers." +"4.1.99.16","Requires Mg2+. Geosmin is the cause of the characteristic smell of moist soil. It is a bifunctional enzyme. The N-terminal part of the enzyme is EC 4.2.3.22, germacradienol synthase, and forms germacradienol from FPP. The C-terminal part of the enzyme catalyses the conversion of germacradienol to geosmin via (1S,4aS,8aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene." +"4.2.3.61",Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium. +"4.2.3.62",Isolated from the liverwort Heteroscyphus planus. cf EC 4.2.3.92 (+)-gamma-cadinene synthase. +"4.2.3.63",Requires Mg2+. +"4.2.3.64",Requires Mg2+. In the bacteria Streptomyces and the liverwort Heteroscyphus the (+)-isomer is formed in contrast to higher plants where the (-)-isomer is formed. +"4.2.3.66",Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium. +"4.2.3.67","The recombinant enzyme from black peppermint (Mentha x piperita) gave a mixture of cis-muurola-3,5-diene (45%) and cis-muurola-4(14),5-diene (43%)." +"4.2.3.68","The recombinant enzyme from ginger (Zingiber zerumbet) gives 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol (cf. EC 4.2.3.84, 10-epi-gamma-eudesmol synthase), 10% alpha-eudesmol (cf. EC 4.2.3.85, alpha-eudesmol synthase), and 5.6% aristolene." +"4.2.3.69","The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% alpha-barbatene, 17.8% thujopsene (cf. EC 4.2.3.79, thujopsene synthase) and 9.9% beta-chamigrene (cf. EC 4.2.3.78, beta-chamigrene synthase) [1] plus traces of other sesquiterpenoids [2]. " +"4.2.3.72",Initial cyclization probably gives biyclogermacrene in an enzyme bound form which is not released to the medium. The enzyme from Solidago canadensis also forms a small amount of (+)-gamma-gurjunene [1]. +"4.2.3.73",The recombinant enzyme from Vitis vinifera gave 49.5% (+)-valencene and 35.5% (-)-7-epi-alpha-selinene. Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium. +"6.4.1.8","The enzyme is involved in anaerobic degradation of ethylbenzene. No activity with acetone, butanone, 4-hydroxy-acetophenone or 4-amino-acetophenone. " +"1.1.1.312","The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4]." +"1.1.1.313","Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyse this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells. cf. EC 1.1.1.433, sulfoacetaldehyde reductase (NADH)." +"1.1.1.314","In Lactuca sativa EC 1.1.1.314 is a mutifunctional enzyme with EC 1.14.13.123, germacrene A hydroxylase [2]." +"1.2.7.10",Contains thiamine diphosphate and [4Fe-4S] clusters. Acceptors include ferredoxin and the nickel-dependent carbon monoxide dehydrogenase (EC 1.2.7.4) +"1.3.1.87",This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation. +"1.3.5.5",This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. The enzyme from Synechococcus can also use NAD+ and NADP+ as electron acceptor under anaerobic conditions. The enzyme from Gentiana lutea shows no activity with NAD+ or NADP+ [1]. +"1.3.7.8","An iron-sulfur protein. Requires Mg2+ or Mn2+. Inactive towards aromatic acids that are not CoA esters but will also catalyse the reaction: ammonia + acceptor + 2 ADP + 2 phosphate = hydroxylamine + reduced acceptor + 2 ATP + H2O. In the presence of reduced acceptor, but in the absence of oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to ADP plus phosphate." +"1.3.7.9",A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3]. +"1.3.8.1","Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme catalyses the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms. The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. The highest activity was reported with either butanoyl-CoA [2] or pentanoyl-CoA [4]. The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA [6]. cf. EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase." +"1.3.98.1","Binds FMN. The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor." +"1.4.98.1","Contains tryptophan tryptophylquinone (TTQ) cofactor. The enzyme oxidizes aliphatic monoamines and diamines, histamine and ethanolamine, but not secondary and tertiary amines, quaternary ammonium salts or aromatic amines." +"1.6.5.9","A flavoprotein (FAD or FMN). Occurs in mitochondria of yeast and plants, and in aerobic bacteria. Has low activity with NADPH. Unlike EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating), this enzyme does not pump proteons of sodium ions across the membrane. It is also not sensitive to rotenone." +"1.7.1.14","A heme-thiolate protein (P-450). The enzyme from Fusarium oxysporum utilizes only NADH, but the isozyme from Trichosporon cutaneum utilizes both NADH and NADPH. The electron transfer from NAD(P)H to heme occurs directly, not requiring flavin or other redox cofactors." +"1.7.2.5","The enzyme from Pseudomonas aeruginosa contains a dinuclear centre comprising a non-heme iron centre and heme b3, plus heme c, heme b and calcium; the acceptor is cytochrome c551" +"1.7.5.2",Contains copper. +"1.8.1.17",A molybdoprotein. +"1.8.2.3",The enzyme from Allochromatium vinosum contains covalently bound FAD and covalently-bound c-type hemes. +"1.8.2.4","The enzyme from the bacterium Rhodovulum sulfidophilum binds molybdopterin guanine dinucleotide, heme b and [4Fe-4S] clusters." +"1.8.3.6",A flavoprotein (FAD). In contrast to mammalian EC 1.8.3.5 (prenylcysteine oxidase) the farnesylcysteine lyase from Arabidopsis is specific for S-farnesyl-L-cysteine and shows no activity with S-geranylgeranyl-L-cysteine. +"1.8.5.4","Contains FAD. Ubiquinone, plastoquinone or menaquinone can act as acceptor in different species. In some organisms the enzyme catalyses the formation of sulfur globules. It repeats the catalytic cycle without releasing the product, producing a polysulfide of up to 10 sulfur atoms. The reaction stops when the maximum length of the polysulfide that can be accommodated in the sulfide oxidation pocket is achieved. The enzyme also plays an important role in anoxygenic bacterial photosynthesis. cf. EC 1.8.5.8, sulfide quinone oxidoreductase." +"1.10.3.9","Contains chlorophyll a, beta-carotene, pheophytin, plastoquinone, a Mn4Ca cluster, heme and non-heme iron. Four successive photoreactions, resulting in a storage of four positive charges, are required to oxidize two water molecules to one oxygen molecule." +"1.10.3.10","Contains a dinuclear centre comprising two hemes, or heme and copper. This terminal oxidase enzyme generates proton motive force by two mechanisms: (1) transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water, and (2) active pumping of protons across the membrane. The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) depends on the enzyme; for example, for the bo3 oxidase it is 2, while for the bd-II oxidase it is 1. cf. EC 1.10.3.14, ubiquinol oxidase (electrogenic, non H+-transporting)." +"1.10.3.11","The enzyme, described from the mitochondria of plants and some fungi and protists, is an alternative terminal oxidase that is not sensitive to cyanide inhibition and does not generate a proton motive force. Unlike the electrogenic terminal oxidases that contain hemes (cf. EC 7.1.1.3 and EC 7.1.1.7), this enzyme contains a dinuclear non-heme iron complex. The function of this oxidase is believed to be dissipating excess reducing power, minimizing oxidative stress, and optimizing photosynthesis in response to changing conditions." +"1.10.3.12","Cytochrome aa3-600, one of the principal respiratory oxidases from Bacillus subtilis, is a member of the heme-copper superfamily of oxygen reductases, and is a close homologue of the cytochrome bo3 ubiquinol oxidase from Escherichia coli, but uses menaquinol instead of ubiquinol as a substrate.The enzyme also pumps protons across the membrane bilayer, generating a proton motive force." +"1.11.1.21","Differs from EC 1.11.1.7, peroxidase in having a relatively high catalase (EC 1.11.1.6) activity with H2O2 as donor, releasing O2; both activities use the same heme active site. In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid." +"1.12.1.4",The enzyme from Thermotoga maritima contains a [FeFe] cluster (H-cluster) and iron-sulfur clusters. It works in the direction evolving hydrogen as a means of eliminating excess reducing equivalents. +"1.13.11.57","Contains non-heme Fe2+. The enzyme is a ring-cleavage dioxygenase that acts specifically on 3,4,5-trihydroxybenzoate to produce the keto-tautomer of 4-oxalomesaconate [1,2]." +"1.13.11.58","Contains nonheme iron. A common plant lipoxygenase that oxidizes linoleate and alpha-linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C9 position with (S)-configuration. The enzyme plays a physiological role during the early stages of seedling growth. The enzyme from Arabidopsis thaliana shows comparable activity towards linoleate and linolenate [4]. EC 1.13.11.12 (linoleate 13S-lipoxygenase) catalyses a similar reaction at another position of these fatty acids." +"1.14.11.33","Contains iron; activity is slightly stimulated by ascorbate. Catalyses oxidative demethylation of the DNA base lesions N1-methyladenine, N3-methylcytosine, N1-methylguanine, and N3-methylthymine. It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA." +"1.14.13.123","A heme-thiolate protein (P-450). This is probably part of the biosynthesis of many sesquiterpenoid lactones. In Lactuca sativa EC 1.14.13.123 is a mutifunctional enzyme with EC 1.1.1.314, germacrene A alcohol dehydrogenase [2]." +"1.14.13.124","A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-phenylalanine, the first committed steps in the biosynthesis of benzylglucosinolate. The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is extremely labile and dehydrates spontaneously.The dehydrated product is then subject to a decarboxylation that produces the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The product, (E)-phenylacetaldoxime, undergoes a spontaneous isomerization to the (Z) form." +"1.14.13.125","A heme-thiolate protein (P-450). This enzyme catalyses two successive N-hydroxylations of L-tryptophan, the first steps in the biosynthesis of both auxin and the indole alkaloid phytoalexin camalexin. The product of the two hydroxylations, N,N-dihydroxy-L-tryptophan, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme." +"1.14.13.126","A heme-thiolate enzyme (P-450). The second donor, NADPH, donates electrons through EC 1.18.1.2, ferredoxin--NADP+ reductase and a [2Fe-2S] ferredoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not." +"1.14.13.127",A flavoprotein (FAD). This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds. +"1.14.13.128",A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida prefers NADH over NADPH. The enzyme is specific for 7-methylxanthine [2]. Forms part of the caffeine degradation pathway. +"1.14.13.129",Requires ferredoxin and Fe(II). Also acts on other carotenoids with a beta-end group. In some species canthaxanthin is the preferred substrate. +"1.14.13.130",A flavoprotein (FAD). The enzyme initiates the degradation of pyrrole-2-carboxylate. +"1.14.18.3","Contains copper. It is membrane-bound, in contrast to the soluble methane monooxygenase (EC 1.14.13.25)." +"1.14.19.7","Contains one non-heme iron centre per monomer [1,5]. FMN is required to mediate the transfer of reducing equivalents from NADH to the active site iron [1]. This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species." +"1.14.99.42","The enzyme, characterized from the plant Crocus sativus, acts twice on zeaxanthin, cleaving 3-hydroxycyclocitral off each 3-hydroxy end group. It is part of the zeaxanthin degradation pathway in that organism, leading to the different compounds that impart the color, flavor and aroma of the saffron spice." +"1.14.99.43",A heme-thiolate protein (P-450). +"1.14.99.44","Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group." +"1.14.99.45",A cytochrome P-450 heme-thiolate enzyme. Also acts on zeinoxanthin to give lutein. +"1.16.5.1","A diheme cytochrome that transfers electrons across a single membrane, such as the outer membrane of the enterocyte, or the tonoplast membrane of the plant cell vacuole. Acts on hexacyanoferrate(III) and other ferric chelates." +"1.16.98.1","Contains c-type heme, The enzyme in Acidithiobacillus ferrooxidans is a component of an electron transfer chain from Fe(II), comprising this enzyme, the copper protein rusticyanin, cytochrome c4, and cytochrome c oxidase (EC 1.9.3.1)" +"2.1.1.207","The enzyme from Escherichia coli catalyses the 2'-O-methylation of cytidine or 5-carboxymethylaminomethyluridine at the wobble position at nucleotide 34 in tRNALeuCmAA and tRNALeucmnm5UmAA. The enzyme is selective for the two tRNALeu isoacceptors and only methylates these when they present the correct anticodon loop sequence and modification pattern. Specifically, YibK requires a pyrimidine nucleoside at position 34, it has a clear preference for an adenosine at position 35, and it fails to methylate without prior addition of the N6-(isopentenyl)-2-methylthioadenosine modification at position 37. " +"2.3.1.196",The enzyme is involved in volatile benzenoid and benzoic acid biosynthesis. The enzyme from Petunia hybrida also catalyses the formation of 2-phenylethyl benzoate from benzoyl-CoA and 2-phenylethanol. The apparent catalytic efficiency of the enzyme from Petunia hybrida with benzoyl-CoA is almost 6-fold higher than with acetyl-CoA [1]. +"2.4.1.262","Requires a divalent ion, Mg2+ better than Mn2+, better than Ca2+. Also acts on soysapogenol A and E." +"2.4.1.263","The enzyme acts better on (S)-2-trans-abscisate than the natural (S)-2-cis isomer, abscisate, or its enantiomer, the (R)-2-cis isomer." +"2.7.1.170","This enzyme, along with EC 4.2.1.126, N-acetylmuramic acid 6-phosphate etherase, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling. The product N-acetylmuramate 6-phosphate is produced as a 7:1 mixture of the alpha- and beta-anomers. " +"3.1.1.86",The degradation of rhamnogalacturonan by rhamnogalacturonases depends on the removal of the acetyl esters from the substrate [1]. +"3.1.3.84","The enzyme is highly specific for ADP-D-ribose 1''-phosphate. Involved together with EC 3.1.4.37, 2',3'-cyclic-nucleotide 3'-phosphodiesterase, in the breakdown of adenosine diphosphate ribose 1'',2''-cyclic phosphate (Appr>p), a by-product of tRNA splicing." +"3.2.1.170",The enzyme occurs in thermophilic bacteria and has been characterized in Thermus thermophilus and Rubrobacter radiotolerans. It also has been identified in the moss Selaginella moellendorffii. +"4.2.1.122","Most mesophilic bacteria have a multimeric tryptophan synthase complex (EC 4.2.1.20) that forms L-tryptophan from L-serine and 1-C-(indol-3-yl)glycerol 3-phosphate via an indole intermediate. This intermediate, which is formed by the alpha subunits, is transferred in an internal tunnel to the beta units, which convert it to tryptophan. In thermophilic organisms the high temperature enhances diffusion and causes the loss of indole. This enzyme, which does not combine with the alpha unit to form a complex, salvages the lost indole back to L-tryptophan. It has a much lower Km for indole than the beta subunit of EC 4.2.1.20." +"4.2.1.123",The reaction occurs in the reverse direction. +"4.2.1.124",The reaction occurs in the reverse direction. +"4.2.1.125",The reaction occurs in the reverse direction. +"4.2.1.126","This enzyme, along with EC 2.7.1.170, anhydro-N-acetylmuramic acid kinase, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling." +"4.2.3.74","Requires Mg2+. Presilphiperfolan-8beta-ol is the precursor of botrydial, a phytotoxic sesquiterpene metabolite secreted by the fungus Botryotinia fuckeliana (Botrytis cinerea), the causal agent of gray mold disease in plants." +"5.3.3.16","This enzyme has been characterized from the bacterium Pseudomonas putida KT2440 and is involved in the degradation pathway of syringate and gallate. It catalyses the interconversion of two of the tautomers of 4-oxalomesaconate, a reaction that can also occur spontaneously." +"5.4.99.32","(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid." +"5.4.99.34","The enzyme produces germanicol, beta-amyrin and lupeol in the ratio 63:33:4." +"5.4.99.35","The enzyme gives taraxerol, beta-amyrin and lupeol in the ratio 70:17:13." +"6.3.2.37","Involved in the synthesis of cell-wall peptidoglycan. The D-lysine is attached to the peptide chain at the N6 position. The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase." +"4.2.3.75",In Solidago canadensis the biosynthesis results in the pro-R hydrogen at C-1 of the farnesy diphosphate ending up at C-11 of the (-)-germacrene D [1]. With Streptomyces coelicolor the pro-S hydrogen at C-1 ends up at C-11 of the (-)-germacrene D [2]. +"4.2.3.76",Initial cyclization gives germacrene C in an enzyme bound form which is not released to the medium. +"4.2.3.77","Requires Mg2+, Mn2+, Ni2+ or Co2+. The formation of (+)-germacrene D involves a 1,2-hydride shift whereas for (-)-germacrene D there is a 1,3-hydride shift (see EC 4.2.3.75)." +"1.3.5.6",This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. +"1.3.99.26",This enzyme is involved in carotenoid biosynthesis. +"1.3.99.27","The enzymes from Rubrivivax gelatinosus and Rhodobacter sphaeroides prefer the acyclic carotenoids (e.g. 1-hydroxy-1,2-dihydroneurosporene, 1-hydroxy-1,2-dihydrolycopene) as substrates. The conversion rate for the 3,4-desaturation of the monocyclic 1'-hydroxy-1',2'-dihydro-gamma-carotene is lower [2,3]. The enzyme from the marine bacterium strain P99-3 shows high activity with the monocyclic carotenoid 1'-hydroxy-1',2'-dihydro-gamma-carotene [1]. The enzyme from Rhodobacter sphaeroides utilizes molecular oxygen as the electron acceptor in vitro [3]. However, oxygen is unlikely to be the natural electron acceptor under anaerobic conditions." +"1.3.99.28","This enzyme is involved in carotenoid biosynthesis and catalyses up to three desaturation steps (cf. EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)], EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)], EC 1.3.99.31 [phytoene desaturase (lycopene-forming)]). The enzyme is activated by FAD. NAD+, NADP+ or ATP show no activating effect [1]. " +"1.3.99.29","The enzyme is involved in carotenoid biosynthesis and catalyses up to two desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)] and EC 1.3.99.31 [phytoene desaturase (lycopene-forming)])." +"1.3.99.30","This enzyme is involved in carotenoid biosynthesis and catalyses up to five desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] and EC 1.3.99.31 [phytoene desaturase (lycopene-forming)])." +"1.3.99.31","Requires FAD. The enzyme is involved in carotenoid biosynthesis and catalyses up to four desaturation steps (cf. EC 1.3.99.28 [phytoene desaturase (neurosporene-forming)], EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] and EC 1.3.99.30 [phytoene desaturase (3,4-didehydrolycopene-forming)])." +"1.5.1.36","The enzyme from Escherichia coli W catalyses the reduction of free flavins by NADH. The enzyme has similar affinity to FAD, FMN and riboflavin. Activity with NADPH is more than 2 orders of magnitude lower than activity with NADH." +"1.16.1.9","Contains FAD. The enzyme, which is widespread among bacteria, catalyses the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron. The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine [3]. cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H]." +"1.97.1.12","Contains chlorophyll, phylloquinones, carotenoids and [4Fe-4S] clusters. +Cytochrome c6 can act as an alternative electron donor, and flavodoxin as an alternative acceptor in some species." +"2.1.1.209","Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (guanine2535-N1)-methyltransferase and EC 2.1.1.208 [23S rRNA (uridine2479-2-O)-methyltransferase], whose actions confer avilamycin resistance to the RNA. " +"2.1.1.210","In Rhodopseudomonas capsulata and Rubrivivax gelatinosus the enzyme is involved in biosynthesis of spheroidene [1,2,3]. In Rubrivivax gelatinosus the enzyme also catalyses the methylation of demethylspirilloxanthin to spirilloxanthin and the methylation of 3,4-didehydrorhodopin to anhydrorhodovibrin [2]. " +"2.4.1.264",The enzyme is involved in the biosynthesis of the exopolysaccharides xanthan (in the bacterium Xanthomonas campestris) and acetan (in the bacterium Gluconacetobacter xylinus). +"2.4.1.265","The successive addition of three glucose residues by EC 2.4.1.267 (dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase), EC 2.4.1.265 and EC 2.4.1.256 (dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly. " +"2.4.1.266","The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate via the two-step pathway in which glucosyl-3-phosphoglycerate synthase catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by EC 3.1.3.85 glucosyl-3-phosphoglycerate phosphatase. The activity is dependent on divalent cations (Mn2+, Co2+, or Mg2+). The enzyme from Persephonella marina shows moderate flexibility on the sugar donor concerning the nucleotide moiety (UDP-glucose, ADP-glucose, GDP-glucose) but is strictly specific for glucose. The enzyme is also strictly specific for 3-phospho-D-glycerate as acceptor [1]. The enzyme from Methanococcoides burtonii is strictly specific for GDP-glucose and 3-phospho-D-glycerate [2]. This enzyme catalyses the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria [4,5]. " +"2.4.1.267","The successive addition of three glucose residues by EC 2.4.1.267, EC 2.4.1.265 (Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase) and EC 2.4.1.256 (Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly. " +"2.4.1.268","Persephonella marina possesses two enzymic systems for the synthesis of glucosylglycerate. The first one is a single-step pathway in which glucosylglycerate synthase catalyses the synthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate in one-step from ADP-glucose and D-glycerate. The second system is a two-step pathway in which EC 2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of NDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by EC 3.1.3.85 (glucosyl-3-phosphoglycerate phosphatase). " +"2.4.1.269","Rhodothermus marinus can also form mannosylglycerate via a two-step pathway catalysed by EC 2.4.1.217 (mannosyl-3-phosphoglycerate synthase) and EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase) [1]. Depending on experimental conditions mannosylglycerate synthase is more or less specific for the GDP-mannose and D-glycerate [1,2]." +"2.4.1.270",The enzyme is involved in synthesis of 2-[2-O-(alpha-D-mannopranosyl)-alpha-D-glucopyranosyl]-D-glycerate. Petrotoga miotherma and Petrotoga mobilis accumulate this compound in response to water stress imposed by salt. +"2.4.2.44","No activity with S-methyl-5'-thioadenosine. The catabolism of of 5'-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5'-thioinosine (EC 3.5.4.31, S-methyl-5'-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1]. " +"2.7.1.171","Non-enzymic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from non-enzymically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. cf. EC 2.7.1.172, protein-ribulosamine 3-kinase." +"2.7.1.172","This enzyme plays a role in freeing proteins from ribulosamines or psicosamines, which might arise from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by EC 2.7.1.171 (protein-fructosamine 3-kinase), which has, in addition, the unique capacity to phosphorylate fructosamines [1]. The plant enzyme also phosphorylates [protein]-N6-D-erythrulosyl-L-lysine [2]. No activity with [protein]-N6-D-fructosyl-L-lysine [1,2]." +"2.7.7.74","In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments." +"2.7.7.75","Catalyses the activation of molybdopterin for molybdenum insertion. In eukaryotes, this reaction is catalysed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). The reaction requires a divalent cation such as Mg2+ or Mn2+. " +"2.7.7.76",Catalyses the cytidylation of the molybdenum cofactor. This modification occurs only in prokaryotes. Divalent cations such as Mg2+ or Mn2+ are required for activity. ATP or GTP cannot replace CTP. +"2.7.8.34","In many organisms this activity is catalysed by a bifunctional enzyme. The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP-1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3-phosphate, a widespread organic solute in microorganisms adapted to hot environments." +"2.10.1.1","Catalyses the insertion of molybdenum into the ene-dithiol group of molybdopterin. In eukaryotes this reaction is catalysed by the N-terminal domain of a fusion protein whose C-terminal domain catalyses EC 2.7.7.75, molybdopterin adenylyltransferase. Requires divalent cations such as Mg2+ or Zn2+ for activity." +"3.1.1.87",The enzyme is involved in degradation of fumonisin B1 [1]. +"3.1.1.88","The enzyme is involved in degradation of pyrethroid pesticides. The enzymes from Sphingobium sp., Klebsiella sp. and Aspergillus niger hydrolyse cis-permethrin at approximately equal rate to trans-permethrin [1-3]. The enzyme from mouse hydrolyses trans-permethrin at a rate about 22-fold higher than cis-permethrin [4]. " +"3.1.3.85","The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. In vivo the enzyme catalyses the dephosphorylation of 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate with lower efficiency [1,2]. Divalent metal ions (Mg2+, Mn2+ or Co2+) stimulate activity [1,2]." +"3.2.1.171",The enzyme is part of the degradation system for rhamnogalacturonan I in Aspergillus aculeatus. +"3.2.1.172",The enzyme is part of the degradation system for rhamnogalacturonan I in Bacillus subtilis strain 168. +"3.2.1.173",The enzyme is part of the degradation system for rhamnogalacturonan I in Aspergillus aculeatus. +"3.2.1.174",The enzyme is part of the degradation system for rhamnogalacturonan I in Aspergillus aculeatus. +"3.2.1.175","The enzyme hydrolzes the biologically inactive beta-D-glucopyranosyl ester of abscisic acid to produce active abscisate. Abscisate is a phytohormone critical for plant growth, development and adaption to various stress conditions. The enzyme does not hydrolyse beta-D-glucopyranosyl zeatin [1]. " +"3.4.11.25",Sphingosinicella xenopeptidilytica strain 3-2W4 is able to utilize the beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu as sole carbon and energy sources [2]. +"3.5.4.31",The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 3.5.4.28) and has some activity against adenosine. Adenosine 5'-phosphate and S-adenosyl-L-methionine (SAM) are not substrates. +"4.1.1.91","In the reverse direction the enzyme catalyses the regioselective carboxylation of phenol into stoichiometric amounts of salicylate. The enzyme also catalyses the reversible decarboxylation of 2,4-dihydroxybenzoate, 2,6-dihydroxybenzoate, 2,3-dihydroxybenzoate and 4-aminosalicylate [1]. " +"4.1.1.92","Activated by Zn2+, Mn2+ or Mg2+. " +"4.2.1.127","In absence of oxygen the bifunctional linalool dehydratase-isomerase can catalyse in vitro two reactions, the hydration of myrcene to (3S)-linalool and the isomerization of (3S)-linalool to geraniol, the latter activity being classified as EC 5.4.4.4, geraniol isomerase." +"4.2.1.128","The reaction occurs in the reverse direction. The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol. See EC 5.4.99.41 (lupeol synthase)." +"4.2.1.129",The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1. +"4.2.2.23",The enzyme is part of the degradation system for rhamnogalacturonan I in Bacillus subtilis strain 168 and Aspergillus aculeatus. +"4.2.2.24",The enzyme is part of the degradation system for rhamnogalacturonan I in Bacillus subtilis strain 168. +"5.2.1.13",Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis. +"5.3.3.17","The enzyme is involved in phenazine biosynthesis. The product probably spontaneously dimerises to 1,4,5a,6,9,10a-hexahydrophenazine-1,6-dicarboxylate" +"5.4.4.4","In absence of oxygen the bifunctional linalool dehydratase-isomerase can catalyse in vitro two reactions, the isomerization of (3S)-linalool to geraniol and the hydration of myrcene to (3S)-linalool, the latter activity being classified as EC 4.2.1.127, linalool dehydratase. " +"5.4.99.38","The product is 97% camelliol, 2% achilleol A and 0.2% beta-amyrin. Achilleol is an isomer of camelliol C with a 4-methylenecyclohexanol ring system. This enzyme probably evolved from EC 5.4.99.39, beta-amyrin synthase. " +"5.4.99.39","Some organism possess a monofunctional beta-amyrin synthase [3,4,6-11], other have a multifunctional enzyme that also catalyses the synthesis of alpha-amyrin (EC 5.4.99.40) [5] or lupeol (EC 5.4.99.41) [6]." +"5.4.99.40","A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39, beta-amyrin synthase)." +"5.4.99.41","Also forms some beta-amyrin. The recombinant enzyme from Arabidopsis thaliana [3] gives a 1:1 mixture of lupeol and lupan-3beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol. See EC 4.2.1.128 (lupan-3beta,20-diol synthase)." +"6.2.1.37","The enzyme works equally well with 4-hydroxybenzoate but shows low activity towards benzoate, 4-aminobenzoate, 3-aminobenzoate, 3-fluorobenzoate, 4-fluorobenzoate, 3-chlorobenzoate, and 4-chlorobenzoate. There is no activity with 3,4-dihydroxybenzoate, 2,3-dihydroxybenzoate, and 2-hydroxybenzoate as substrates. " +"6.3.4.19",The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34. This modification determines both codon and amino acid specificities of tRNAIle. +"1.3.1.89",A flavoenzyme. The enzyme specifically modifies uracil47 in tRNA. +"1.3.1.90",A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA. +"1.3.1.91",A flavoenzyme [3]. The enzyme specifically modifies uracil20 in tRNA. +"1.3.8.2","The enzyme catalyses four successive dehydrogenations, resulting in production of 4,4'-diapolycopene. While the enzyme from Staphylococcus aureus was only shown to produce 4,4'-diaponeurosporene in vivo [4], it is able to catalyse the last reaction in vitro [5]." +"1.5.1.37","The enzyme from Burkholderia phenoliruptrix can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. Unlike EC 1.5.1.36, flavin reductase (NADH), the enzyme can not reduce riboflavin. The enzyme does not use NADPH as acceptor." +"1.5.1.38","The enzymes from bioluminescent bacteria contain FMN [4], while the enzyme from Escherichia coli does not [8]. The enzyme often forms a two-component system with monooxygenases such as luciferase. Unlike EC 1.5.1.39, this enzyme does not use NADH as acceptor [1,2]. While FMN is the preferred substrate, the enzyme can also use FAD and riboflavin with lower activity [3,6,8]. " +"1.5.1.39","Contains FMN. The enzyme can utilize NADH and NADPH with similar reaction rates. Different from EC 1.5.1.42, FMN reductase (NADH) and EC 1.5.1.38, FMN reductase (NADPH). The luminescent bacterium Vibrio harveyi possesses all three enzymes [1]. Also reduces riboflavin and FAD, but more slowly. " +"1.5.1.40",The enzyme has an absolute requirement for both the 5-deazaflavin structure and the presence of an 8-hydroxy group in the substrate [1]. +"1.5.1.41","Catalyses the reduction of soluble flavins by reduced pyridine nucleotides. Highest activity with riboflavin. When NADH is used as acceptor, the enzyme can also utilize FMN and FAD as substrates, with lower activity than riboflavin. When NADPH is used as acceptor, the enzyme has a very low activity with FMN and no activity with FAD [1]." +"1.5.1.42","The enzyme often forms a two-component system with monooxygenases. Unlike EC 1.5.1.38, FMN reductase (NADPH), and EC 1.5.1.39, FMN reductase [NAD(P)H], this enzyme has a strong preference for NADH over NADPH, although some activity with the latter is observed [1,2]. +While FMN is the preferred substrate, FAD can also be used with much lower activity [1,3]. " +"1.7.6.1",Contains ferriheme b. The enzyme is one of the nitrophorins from the salivary gland of the blood-feeding insect Rhodnius prolixus. Nitric oxide produced induces vasodilation after injection. Nitrophorins 2 and 4 can also catalyse this reaction. +"2.1.1.211",The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA). +"2.1.1.212","Specifically methylates 2,4',7-trihydroxyisoflavanone on the 4'-position. No activity with isoflavones [2]. The enzyme is involved in formononetin biosynthesis in legumes [1]. The protein from pea (Pisum sativum) also methylates (+)-6a-hydroxymaackiain at the 3-position (cf. EC 2.1.1.270, (+)-6a-hydroxymaackiain 3-O-methyltransferase) [4]." +"2.1.1.214","In contrast to the archaeal enzyme tRNA (guanine10-N2)-dimethyltransferase (EC 2.1.1.213), tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA. " +"2.1.1.215","The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216, tRNA (guanine26-N2)-dimethyltransferase). However, it catalyses the double methylation of guanines at both positions 26 and 27 of tRNA." +"2.1.1.216","The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions. In contrast to EC 2.1.1.215, tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase, this enzyme does not catalyse the methylation of guanine27 in tRNA." +"2.1.1.217",The enzyme specifically methylates adenine22 in tRNA. +"2.1.1.218","The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA [1]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of guanine9 in tRNA (cf. EC 2.1.1.221, tRNA (guanine9-N1)-methyltransferase). " +"2.1.1.219","The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNAAsp). Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs." +"2.1.1.220",The enzyme specifically methylates adenine58 in tRNA. The methylation of A58 is critical for maintaining the stability of initiator tRNAMet in yeast [3]. +"2.1.1.221","The enzyme from Saccharomyces cerevisiae specifically methylates guanine9 [1,2]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of adenine9 in tRNA (cf. EC 2.1.1.218, tRNA (adenine9-N1)-methyltransferase) [1]. " +"2.1.1.222","UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli. The second methylation is classified as EC 2.1.1.64 (3-demethylubiquinol 3-O-methyltransferase) [2]. In eukaryotes Coq3 catalyses the two methylation steps in ubiquinone biosynthesis. However, while the second methylation is common to both enzymes, the first methylation by Coq3 occurs at a different position within the pathway, and thus involves a different substrate and is classified as EC 2.1.1.114 (polyprenyldihydroxybenzoate methyltransferase). The substrate of the eukaryotic enzyme (3,4-dihydroxy-5-all-trans-polyprenylbenzoate) differs by an additional carboxylate moiety." +"2.1.1.223",The enzyme specifically methylates adenine37 in tRNA1Val (anticodon cmo5UAC). +"2.1.1.224","This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the appended methyl group. It contains an [4Fe-4S] cluster [3,6,7]. Cfr is an plasmid-acquired methyltransferase that protects cells from the action of antibiotics [1]. The enzyme methylates adenosine at position 2503 of 23S rRNA by a radical mechanism, transferring a CH2 group from S-adenosyl-L-methionine while retaining the hydrogen at the C-8 position of the adenine. Cfr first transfers an CH2 group to a conserved cysteine (Cys338 in Staphylococcus aureus) [7], the generated radical from a second S-adenosyl-L-methionine then attacks the methyl group, exctracting a hydrogen. The formed radical forms a covalent intermediate with the adenine group of the tRNA [8]. The enzyme will also methylate 2-methyladenine produced by the action of EC 2.1.1.192 [23S rRNA (adenine2503-C2)-methyltransferase]." +"2.1.1.225","The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis." +"2.1.1.226","The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2'-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin. " +"2.1.1.227","The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1409 in helix 44 of 16S rRNA and cytidine1920 in helix 69 of 23S rRNA (cf. EC 2.1.1.226, 23S rRNA (cytidine1920-2'-O)-methyltransferase). " +"2.1.1.228","This enzyme is important for the maintenance of the correct reading frame during translation. Unlike TrmD from Escherichia coli, which recognizes the G36pG37 motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37 [4]." +"2.1.1.229",The enzyme catalyses the posttranslational modification of uridine residues at the wobble position 34 of the anticodon loop of tRNA. +"2.1.1.230","The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton [2]. " +"2.4.1.271","In the plants Crocus sativus and Gardenia jasminoides this enzyme esterifies a free carboxyl group of crocetin and some crocetin glycosyl esters. The enzyme from Gardenia can also form glucosyl esters with 4-coumarate, caffeate and ferulate [3]. " +"2.4.1.272",Part of the biosynthetic pathway for soyasaponins. +"2.4.1.273",Part of the biosynthetic pathway for soyasaponins. +"2.4.1.274",Involved in the synthesis of several different major classes of glycosphingolipids. +"2.8.1.9","Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC 2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein." +"3.2.1.176","Some exocellulases, most of which belong to the glycoside hydrolase family 48 (GH48, formerly known as cellulase family L), act at the reducing ends of cellulose and similar substrates. The CelS enzyme from Clostridium thermocellum is the most abundant subunit of the cellulosome formed by the organism. It liberates cellobiose units from the reducing end by hydrolysis of the glycosidic bond, employing an inverting reaction mechanism [2]. Different from EC 3.2.1.91, which attacks cellulose from the non-reducing end." +"3.2.1.177","The enzyme catalyses hydrolysis of a terminal, unsubstituted xyloside at the extreme reducing end of a xylogluco-oligosaccharide. Representative alpha-xylosidases from glycoside hydrolase family 31 utilize a two-step (double-displacement) mechanism involving a covalent glycosyl-enzyme intermediate, and retain the anomeric configuration of the product." +"3.2.1.178","The backbone of porphyran consists largely (~70%) of (1->3)-linked beta-D-galactopyranose followed by (1->4)-linked alpha-L-galactopyranose-6-sulfate [the other 30% are mostly agarobiose repeating units of (1->3)-linked beta-D-galactopyranose followed by (1->4)-linked 3,6-anhydro-alpha-L-galactopyranose] [2]. This enzyme cleaves the (1->4) linkages between beta-D-galactopyranose and alpha-L-galactopyranose-6-sulfate, forming mostly the disaccharide alpha-L-galactopyranose-6-sulfate-(1->3)-beta-D-galactose, although some longer oligosaccharides of even number of residues are also observed. Since the enzyme is inactive on the non-sulfated agarose portion of the porphyran backbone, some agarose fragments are also included in the products [1]. Methylation of the D-galactose prevents the enzyme from Zobellia galactanivorans, but not that from Wenyingzhuangia fucanilytica, from binding at subsite -1 [2,3]." +"3.4.11.26","Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed." +"3.7.1.14",This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation. The first step of the enzyme mechanism involves a reversible keto-enol tautomerization [4]. +"4.1.1.93","The enzyme catalyses both the carboxylation and decarboxylation reactions. However, while bicarbonate is the preferred substrate for the carboxylation reaction, decarboxylation produces carbon dioxide. The enzyme is activated by carboxylic acids. " +"4.1.2.48","Requires pyridoxal phosphate. The low-specificity L-threonine aldolase can act on both L-threonine and L-allo-threonine [1,2]. The enzyme from Escherichia coli can also act on L-threo-phenylserine and L-erythro-phenylserine [4]. The enzyme can also catalyse the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis [3]. Different from EC 4.1.2.5, L-threonine aldolase, and EC 4.1.2.49, L-allo-threonine aldolase." +"4.1.2.49","Requires pyridoxal phosphate. This enzyme, characterized from the bacterium Aeromonas jandaei, is specific for L-allo-threonine and can not act on either L-threonine or L-serine. Different from EC 4.1.2.5, L-threonine aldolase, and EC 4.1.2.48, low-specificity L-threonine aldolase. A previously listed enzyme with this name, EC 4.1.2.6, was deleted in 1971 after it was found to be identical to EC 2.1.2.1, glycine hydroxymethyltransferase." +"4.1.99.17",Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate. Part of the pathway for thiamine biosynthesis. +"4.1.99.18","The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). The enzyme MoaA from bacteria and the human enzyme MOCS1A each contain two oxygen-sensitive FeS clusters. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. In bacteria, the reaction is catalysed by MoaA and requires the action of MoaC. The latter protein is equivalent to the C-terminal domain of the eukaryotic enzyme MOCS1A which does not need further protein components to perform the reaction." +"4.1.99.19","Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate. The reductant is assumed to be NADPH, which is provided by a flavoprotein:NADPH oxidoreductase system [4]. Part of the pathway for thiamine biosynthesis." +"4.2.1.130","The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase)." +"4.2.2.25","The enzyme is highly specific to gellan, especially deacetylated gellan. " +"4.2.3.78","The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% (+)-alpha-barbatene, 17.8% (+)-thujopsene and 9.9% (+)-beta-chamigrene [1] plus traces of other sesquiterpenoids [2]. See EC 4.2.3.69 (+)-alpha-barbatene synthase, and EC 4.2.3.79 thujopsene synthase." +"4.2.3.79","The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% (+)-alpha-barbatene, 17.8% (+)-thujopsene and 9.9% (+)-beta-chamigrene [1] plus traces of other sesquiterpenoids [2]. See EC 4.2.3.69 (+)-alpha-barbatene synthase, and EC 4.2.3.78 beta-chamigrene synthase." +"4.2.3.80","The enzyme from Norway spruce produces longifolene as the main product (cf. EC 4.2.3.58, longifolene synthase). alpha-Longipinene constitutes about 15% of the total products." +"4.2.3.81","The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (-)-exo-alpha-bergamotene (74%) there were (E)-nerolidol (10%), (Z)-alpha-bisabolene (6%), (E)-beta-farnesene (5%) and beta-sesquiphellandrene (1%)." +"4.2.3.82","The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (+)-alpha-santalene, (-)-beta-santalene and (-)-exo-alpha-bergamotene are formed with traces of (+)-epi-beta-santalene. See EC 4.2.3.83 [(-)-beta-santalene synthase], and EC 4.2.3.81 [(-)-exo-alpha-bergamotene synthase]. cf. EC 4.2.3.50 alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]" +"4.2.3.83","The enzyme synthesizes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate. As well as (-)-beta-santalene (+)-alpha-santalene and (-)-exo-alpha-bergamotene are formed with traces of (+)-epi-beta-santalene. See EC 4.2.3.82 [(+)-alpha-santalene synthase], and EC 4.2.3.81 [(-)-exo-alpha-bergamotene synthase]." +"4.3.3.6","The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. The enzyme complex is found in aerobic bacteria, archaea, fungi and plants." +"5.1.3.24",Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation. This enzyme accelerates maturotation to the beta form via the open form (which also occurs as a slow spontaneous reaction). The open form is necessary for further metabolism by the bacteria. +"5.4.99.42",The enzyme specifically acts on uridine31 in tRNA. +"5.4.99.43",The enzyme specifically acts on uridine2819 in 21S rRNA. +"5.4.99.44",The mitochondrial enzyme Pus2p is specific for position 27 or 28 in mitochondrial tRNA [1]. +"5.5.1.18","The carotenoid lycopene has the psi-end group at both ends. When acting on one end, this enzyme forms delta-carotene. When acting on both ends, it forms epsilon-carotene." +"5.5.1.19","The enzyme is a non-redox flavoprotein, containing FADH2 that is used for stabilization of a transition state. Lycopene has a psi-end group at both ends. When acting on one end, the enzyme forms gamma-carotene. When acting on both ends it forms beta-carotene. It also acts on neurosporene to give beta-zeacarotene. " +"5.3.2.3","The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. Four moieties of alpha-D-rhamnose and two moities of 3-acetamido-3,6-dideoxy-alpha-D-galactose form the repeating unit of the glycan chain in the S-layer of the bacterium Aneurinibacillus thermoaerophilus." +"1.1.1.315","This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal [1] while the substrate is bound to the retinal-binding protein [4]. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol [2]." +"1.2.1.82",Neurosporaxanthin is responsible for the orange color of of Neurospora. +"1.4.9.1","Contains tryptophan tryptophylquinone (TTQ) cofactor. The enzyme oxidizes aliphatic monoamines and diamines, histamine and ethanolamine, but not secondary and tertiary amines, quaternary ammonium salts or aromatic amines." +"1.4.9.2","Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine " +"1.6.5.10","A flavoprotein [1, 2]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [3]. +Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [1]." +"1.13.11.59","It is assumed that 3-methylbut-2-enal is formed. The enzyme cannot cleave the saturated 3',4'-bond of gamma-carotene which implies that a 3',4'-double bond is neccessary for this reaction." +"1.13.12.19","This is one of two simultaneous reactions catalysed by the enzyme, which is responsible for ethene production in bacteria of the Pseudomonas syringae group. In the other reaction [EC 1.14.20.7, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)] the enzyme catalyses the mono-oxygenation of both 2-oxoglutarate and L-arginine, forming succinate, carbon dioxide and 5-hydroxy-L-arginine, which is subsequently cleaved into guanidine and (S)-1-pyrroline-5-carboxylate.The enzymes catalyse two cycles of the ethene-forming reaction for each cycle of the succinate-forming reaction, so that the stoichiometry of the products ethene and succinate is 2:1." +"1.14.11.34","This is one of two simultaneous reactions catalysed by the enzyme, which is responsible for ethylene production in bacteria of the Pseudomonas syringae group.In the other reaction [EC 1.13.12.19, 2-oxoglutarate dioxygenase (ethylene-forming)] the enzyme catalyses the dioxygenation of 2-oxoglutarate forming ethylene and three molecules of carbon dioxide.The enzyme catalyses two cycles of the ethylene-forming reaction for each cycle of the succinate-forming reaction, so that the stoichiometry of the products ethylene and succinate is 2:1." +"1.14.13.131","The enzyme participates exclusively in sulfur dissimilation. It has lower activity with diethyl sulfide and other short-chain alkyl methyl sulfides. Its activity is stimulated by combined addition of FMN, and, after depletion of cations, of Mg2+ and Fe2+. The enzymes from bacteria of the Hyphomicrobium genus are a two component system that includes an FMN-dependent reductase subunit and a monooxygenase subunit." +"1.14.13.132","A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor, NADPH, is coupled via EC 1.6.2.4, NADPH---hemoprotein reductase [5,7]." +"1.14.14.9","The enzyme from Escherichia coli attacks a broad spectrum of phenolic compounds. The enzyme uses FADH2 as a substrate rather than a cofactor [4]. FADH2 is provided by EC 1.5.1.36, flavin reductase (NADH) [5,6]. " +"1.20.9.1","Contains a molybdopterin centre comprising two molybdopterin guanosine dinucleotide cofactors bound to molybdenum, a [3Fe-4S] cluster and a Rieske-type [2Fe-2S] cluster. Isolated from beta-proteobacteria. Also uses a c-type cytochrome or O2 as acceptors." +"2.1.1.231","The enzyme catalyses the 4'-methylation of naringenin. In vitro it catalyses the 4'-methylation of apigenin, quercetin, daidzein and genistein. " +"2.1.1.232","The enzyme is involved in the biosynthesis of the sakuranetin, an inducible defense mechanism of the plant Oryza sativa (Asian rice) against pathogen attack. " +"2.4.1.276",The reaction proceeds in two steps with the monoglucoside as an intermediate. +"2.5.1.96",Requires Mn2+. Typical of Staphylococcus aureus and some other bacteria such as Heliobacillus sp. +"2.8.1.10",H2S can provide the sulfur in vitro. Part of the pathway for thiamine biosynthesis. +"3.1.4.54",This enzyme is involved in the biosynthesis of anandamide. It does not hydrolyse phosphatidylcholine and phosphatidylethanolamine [1]. No transphosphatidation [1]. The enzyme contains Zn2+ and is activated by Mg2+ or Ca2+ [2]. +"4.2.1.131","In Rubrivivax gelatinosus [1] and Thiocapsa roseopersicina [2] both products are formed, whereas Rhodobacter capsulatus [1] only gives 1-hydroxy-1,2-dihydrolycopene. Also acts on neurosporene giving 1-hydroxy-1,2-dihydroneurosporene with both organism but 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene only with Rubrivivax gelatinosus." +"4.2.3.84","The recombinant enzyme from ginger (Zingiber zerumbet) gives 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol, 10% alpha-eudesmol, and 5.6% aristolene. cf. EC 4.2.3.68 (beta-eudesmol synthase) and EC 4.2.3.85 (alpha-eudesmol synthase)" +"4.2.3.85","The recombinant enzyme from ginger (Zingiber zerumbet) gives 62.6% beta-eudesmol, 16.8% 10-epi-gamma-eudesmol, 10% alpha-eudesmol, and 5.6% aristolene. cf. EC 4.2.3.68 (beta-eudesmol synthase) and EC 4.2.3.84 (10-epi-gamma-eudesmol synthase)" +"5.4.99.45","The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC 5.4.99.12, tRNA pseudouridine38-40 synthase) [1]. In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu) [2]. " +"1.1.1.316",The enzyme catalyses a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway). The activity with NADP+ is less than 10% of the activity with NAD+. +"1.1.1.317",The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway. The enzyme is a member of the aldo-keto reductase enzyme superfamily from higher plants. +"1.1.3.42","The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone by some fungi. The bifunctional enzyme catalyses the oxidation of prosolanapyrone II and the subsequent Diels Alder cycloisomerization of the product prosolanapyrone III to (-)-solanapyrone A (cf. EC 5.5.1.20, prosolanapyrone III cycloisomerase). " +"1.1.9.1","A soluble, periplasmic PQQ-containing quinohemoprotein. Also contains a single heme c. Occurs in Comamonas and Pseudomonas. Does not require an amine activator. Oxidizes a wide range of primary and secondary alcohols, and also aldehydes and large substrates such as sterols; methanol is not a substrate. Usually assayed with phenazine methosulfate or ferricyanide. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed β€˜propeller’ structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ." +"1.10.9.1","Contains two b-type cytochromes, two c-type cytochromes (cn and f), and a [2Fe-2S] Rieske cluster. The enzyme plays a key role in photosynthesis, transferring electrons from photosystem II (EC 1.10.3.9) to photosystem I (EC 1.97.1.12). Cytochrome c-552 can act as acceptor instead of plastocyanin, but more slowly. In chloroplasts, protons are translocated through the thylakoid membrane from the stroma to the lumen. The mechanism occurs through the Q cycle as in EC 1.10.2.2, quinol---cytochrome-c reductase (complex III) and involves electron bifurcation." +"1.13.11.60","The enzyme contains heme [1,4]. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is subsequently isomerized by the C-terminal P-450 heme thiolate domain to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.5, 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase) [1]. The bifunctional enzyme from Gaeumannomyces graminis also catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase) [4]." +"1.13.11.61","In cyanobacteria the enzyme is involved in oxylipin biosynthesis. The enzyme also converts linoleate to (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate. " +"1.13.11.62","The enzyme is involved in biosynthesis of oxylipins, which affect sporulation, development, and pathogenicity of Aspergillus spp. " +"1.14.13.133",A heme-thiolate protein (P-450). The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics. +"1.14.13.134","Requires cytochrome P-450. Part of the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-beta-amyrin to 11alpha,30-dihydroxy-beta-amyrin but this is not thought to be part of glycyrrhizin biosynthesis." +"1.14.13.135",The enzyme is involved in the catabolic pathway for the degradation of chrysene in some bacteria [2]. +"1.14.13.136","Requires cytochrome P-450. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively." +"1.14.14.11","The enzyme catalyses the first step in the aerobic styrene degradation pathway. It forms a two-component system with a reductase (StyB) that utilizes NADH to reduce flavin-adenine dinucleotide, which is then transferred to the oxygenase." +"1.14.14.12","This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone. It can use either FADH or FMNH2 as flavin cofactor. The enzyme forms a two-component system with a reductase (HsaB) that utilizes NADH to reduce the flavin, which is then transferred to the oxygenase subunit. " +"1.16.9.1","Contains c-type heme. The enzyme in Acidithiobacillus ferrooxidans is a component of an electron transfer chain from Fe(II), comprising this enzyme, the copper protein rusticyanin, cytochrome c4, and cytochrome-c oxidase (EC 7.1.1.9)." +"1.17.1.7","The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 3.3.2.12, oxepin-CoA hydrolase.Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway." +"1.17.7.2","Contains FAD and an iron-sulfur center. This enzyme, which is present in plant chloroplasts, carries out the second step in the conversion of chlorophyll b to chlorophyll a. It similarly reduces chlorophyllide a." +"2.1.1.234","The enzyme is involved in the biosynthesis of desosamine, a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics such as erthyromycin, azithromycin, and clarithromycin." +"2.1.1.235","The enzyme is involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin, which is produced by the bacterium Streptomyces fradiae." +"2.1.1.236","The enzyme is involved in the synthesis of dTDP-D-ravidosamine, the amino sugar moiety of the antibiotic ravidomycin V, which is produced by the bacterium Streptomyces ravidus." +"2.1.1.237",The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. +"2.1.1.238",The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. Requires Mg2+ for optimal activity. +"2.4.1.277","DesVII is the glycosyltransferase responsible for the attachment of dTDP-D-desosamine to 10-deoxymethynolide or narbonolide during the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in the bacterium Streptomyces venezuelae. Activity requires an additional protein partner, DesVIII." +"2.5.1.97","The enzyme requires a divalent metal ion, the highest activity values are observed in the presence of Mn2+ and Co2+ (10 mM). " +"2.6.1.88","The enzyme is most active with L-methionine. It participates in the L-methionine salvage pathway from S-methyl-5'-thioadenosine, a by-product of polyamine biosynthesis. The enzyme from the bacterium Klebsiella pneumoniae can use several different amino acids as amino donor, with aromatic amino acids being the most effective [1]. The enzyme from the plant Arabidopsis thaliana is also a part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates [3]." +"2.6.1.89",A pyridoxal-phosphate protein. The reaction occurs in the reverse direction. The enzyme is involved in biosynthesis of D-mycaminose. +"2.6.1.90","A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose. The reaction occurs in the reverse direction. " +"2.6.1.91","A pyridoxal-phosphate protein. The enzyme is involved in biosynthesis of UDP-N,N-diacetylbacillosamine, an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-aspargine residues in Campylobacter species [1-3] and O-linked glycosylation of certain L-serine residues in Neisseria species [4]." +"2.6.1.92","A pyridoxal 5'-phosphate protein. The enzyme transfers the primary amino group of L-glutamate to C-4'' of UDP-4-dehydro sugars, forming a C-N bond in a stereo configuration opposite to that of UDP. The enzyme from the bacterium Bacillus cereus has been shown to act on UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose, UDP-beta-L-threo-pentapyranos-4-ulose, UDP-4-dehydro-6-deoxy-D-glucose, and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose. cf. EC 2.6.1.34, UDP-N-acetylbacillosamine transaminase, which catalyses a similar reaction, but forms the C-N bond in the same stereo configuration as that of UDP." +"2.7.7.80","Adenylates the C-terminus of the small subunit of the molybdopterin synthase. This activation is required to form the thiocarboxylated C-terminus of the active molybdopterin synthase small subunit. The reaction occurs in prokaryotes and eukaryotes. In the human, the reaction is catalysed by the N-terminal domain of the protein MOCS3, which also includes a molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) C-terminal domain." +"2.8.1.11","The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of EC 2.8.1.12, molybdopterin synthase. In the human, the reaction is catalysed by the rhodanese-like C-terminal domain (cf. EC 2.8.1.1) of the MOCS3 protein, a bifunctional protein that also contains EC 2.7.7.80, molybdopterin-synthase adenylyltransferase, at the N-terminal domain." +"2.8.1.12","Catalyses the synthesis of molybdopterin from cyclic pyranopterin monophosphate. Two sulfur atoms are transferred to cyclic pyranopterin monophosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor. Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur-carrier proteins) that are thiocarboxylated at the C-terminus by EC 2.8.1.11, molybdopterin synthase sulfurtransferase. The reaction occurs in prokaryotes and eukaryotes." +"3.1.1.89",A key regulator of protein phosphatase 2A. The methyl ester is formed by EC 2.1.1.233 (leucine carboxy methyltransferase-1). Occurs mainly in the nucleus. +"3.1.1.90","All-trans-retinyl esters, which are a storage form of vitamin A, are generated by the activity of EC 2.3.1.135, phosphatidylcholine---retinol O-acyltransferase (LRAT). They can be hydrolysed to 11-cis-retinol by EC 3.1.1.64, retinoid isomerohydrolase (RPE65), or to 13-cis-retinol by this enzyme." +"3.1.3.86","This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects." +"3.1.7.8","Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives isotuberculosinol in 1:1 mixture, cf. EC 3.1.7.9, isotuberculosinol synthase." +"3.1.7.9","Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives tuberculosinol in 1:1 mixture, cf. EC 3.1.7.8, tuberculosinol synthase. The isotuberculosinol form was a 3:1 mixture of the 13S and 13R forms, respectively." +"3.2.1.179","The enzyme releases 4-deoxy-4(5)-unsaturated D-glucuronic acid from oligosaccharides produced by polysaccharide lyases, e.g. the tetrasaccharide beta-D-4-deoxy-Delta4-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp produced by EC 4.2.2.25, gellan lyase. The enzyme can also hydrolyse unsaturated chondroitin and hyaluronate disaccharides (beta-D-4-deoxy-Delta4-GlcAp-(1->3)-D-GalNAc, beta-D-4-deoxy-Delta4-GlcAp-(1->3)-D-GalNAc6S, beta-D-4-deoxy-Delta4-GlcAp2S-(1->3)-D-GalNAc, beta-D-4-deoxy-Delta4-GlcAp-(1->3)-D-GlcNAc), preferring the unsulfated disaccharides to the sulfated disaccharides." +"3.2.1.180","The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. It prefers the sulfated disaccharides to the unsulfated disaccharides." +"3.4.19.13","This is a bifunctional protein that also has the activity of EC 2.3.2.2, gamma-glutamyltransferase. The enzyme binds its substrate by forming an initial gamma-glutamyl-enzyme intermediate, releasing the L-cysteinylglycine part of the molecule. The enzyme then reacts with either a water molecule or a different acceptor substrate (usually an L-amino acid or a dipeptide) to form L-glutamate or a product containing a new gamma-glutamyl isopeptide bond, respectively. The enzyme acts on glutathione, glutathione-S-conjugates, and, at a lower level, on other substrates with an N-terminal L-gamma-glutamyl residue. It plays a crucial part in the glutathione-mediated xenobiotic detoxification pathway. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide." +"3.5.1.109",The enzyme is involved in the sphingolipid metabolism in the epidermis. +"3.6.1.55","This enzyme hydrolyses the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC 3.6.1.56, 2-hydroxy-dATP diphosphatase) [4]. Requires Mg2+." +"3.6.1.56","The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [3]." +"3.6.1.57",The enzyme is involved in biosynthesis of pseudaminic acid. +"3.7.1.15","A multifunctional enzyme which also forms (+)-beta-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-beta-caryophyllene synthase]. Three atoms of deuterium are incorporated into (+)-caryolan-1-ol in the presence of D2O. This is consistent with the proposed mechanism of formation." +"3.7.1.16","The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 1.17.1.7, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. +Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway [1,3,4]. The enzyme from Escherichia coli also exhibits enoyl-CoA hydratase activity utilizing crotonyl-CoA as a substrate [2]." +"4.2.3.86","The recombinant enzyme from Vitis vinifera forms 49.5% (+)-valencene (cf. EC 4.2.3.73, valencene synthase) and 35.5% (-)-7-epi-alpha-selinene. Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium. " +"4.2.3.87","Requires Mg2+. The enzyme from Pogostemon cablin gives 13% alpha-guaiene as well as 37% (-)-patchoulol (see EC 4.2.3.70), 13% delta-guaiene (see EC 4.2.3.93), and traces of at least ten other sesquiterpenoids [1]. In Aquilaria crassna three clones of the enzyme gave about 80% delta-guaiene and 20% alpha-guaiene, with traces of alpha-humulene. A fourth clone gave 54% delta-guaiene and 45% alpha-guaiene [2]." +"4.2.3.88",Viridiflorene is the only product of this enzyme from Solanum lycopersicum. +"4.2.3.89","A multifunctional enzyme which also converts the (+)-beta-caryophyllene to (+)-caryolan-1-ol (see EC 4.2.1.138, (+)-caryolan-1-ol synthase). cf. EC 4.2.3.57 (-)-beta-caryophyllene synthase." +"4.2.3.90","Requires Mg2+. The enzyme forms 5-epi-alpha-selinene possibly via germecrene A or a 1,6-hydride shift mechanism." +"4.2.3.91","Requires Mg2+. The enzyme gives 28% cubebol, 29% (-)-germacrene D, 10% (+)-delta-cadinene and traces of several other sesquiterpenoids. See also EC 4.2.3.75 (–)-germacrene D synthase and EC 4.2.3.13 (+)-delta-cadinene synthase." +"4.2.3.92","The cloned enzyme from the melon, Cucumis melo, gave mainly delta- and gamma-cadinene with traces of several other sesquiterpenoids cf. EC 4.2.3.62 (-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]; EC 4.2.3.13 (+)-delta-cadinene synthase." +"4.2.3.93","Requires Mg2+. In Aquilaria crassna three clones of the enzyme gave about 80% delta-guaiene and 20% alpha-guaiene (see also EC 4.2.3.87). A fourth clone gave 54% delta-guaiene and 45% alpha-guaiene [2]. +The enzyme from Pogostemon cablin gives 13% delta-guaiene as well as 37% (-)-patchoulol (see EC 4.2.3.70), 13% alpha-guaiene (see EC 4.2.3.87), and traces of at least ten other sesquiterpenoids [1]." +"5.3.2.4",The enzyme is involved in biosynthesis of D-mycaminose. +"5.3.3.18","The enzyme catalyses the reversible isomerization of 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA to the unusual unsaturated, oxygen-containing, seven-member heterocyclic enol ether 2-oxepin-2(3H)-ylideneacetyl-CoA, as part of an aerobic phenylacetate degradation pathway." +"5.4.4.5","The enzyme contains heme [3]. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P-450 heme thiolate domain [3]." +"5.4.4.6","The enzyme contains heme. The bifunctional enzyme from Gaeumannomyces graminis catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is then isomerized to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate [3]." +"5.4.99.46",The enzyme gives traces of four other triterpenoids +"5.4.99.47",The enzyme from rice (Oryza sativa) produces parkeol as a single product [1]. +"5.4.99.48","Achilleol B is probably formed by cleavage of the 8-14 and 9-10 bonds of (3S)-2,3-epoxy-2,3-dihydrosqualene as part of the cyclization reaction, after formation of the oleanane skeleton." +"5.4.99.49",The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids. +"5.4.99.50",The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids. +"5.4.99.51", The enzyme from Stevia rebaudiana also gives traces of other triterpenoids. +"5.4.99.52","The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin. See EC 5.4.99.54, beta-seco-amyrin synthase." +"5.4.99.53","Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization." +"5.4.99.54","The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin. See EC 5.4.99.52, alpha-seco-amyrin synthase." +"5.4.99.55","The enzyme from tomato (Solanum lycopersicum) gives 48% delta-amyrin, 18% alpha-amyrin, 13% beta-amyrin and traces of three or four other triterpenoid alcohols [1]. See also EC 5.4.99.40, alpha-amyrin synthase and EC 5.4.99.39, beta-amyrin synthase." +"5.4.99.56","The product from Arabidopsis thaliana is 85% tirucalla-7,24-dien-3beta-ol with trace amounts of other triterpenoids." +"5.5.1.20","The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi. The bifunctional enzyme catalyses the oxidation of prosolanapyrone II and the subsequent Diels Alder cycloisomerization of the product prosolanapyrone III to (-)-solanapyrone A (cf. EC 1.1.3.42, prosolanapyrone II oxidase). " +"1.5.8.3","A flavoprotein (FMN) found in eukaryotes. In the absence of tetrahydrofolate the enzyme produces formaldehyde. cf. EC 1.5.3.1, sarcosine oxidase (formaldehyde-forming), and EC 1.5.3.24, sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)." +"1.5.8.4","A flavoprotein, containing a histidyl(Npi)-(8alpha)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel [5,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [5,9]." +"1.14.13.137","The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases." +"1.14.13.138","The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases." +"1.14.13.139","The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases." +"1.14.13.140","The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases." +"1.14.13.141","This enzyme, found in several bacterial pathogens, is involved in degradation of the host's cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol [4]. The products are exclusively in the (25S) configuration. It is a two-component system consisting of a P-450 (heme thiolate) oxygenase (Cyp125) and a ferredoxin reductase (most likely KshB, which is also a part of EC 1.14.13.142, 3-ketosteroid 9alpha-monooxygenase). The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.15.28, cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]." +"1.14.13.142","The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It is a two-component system consisting of a terminal oxygenase (KshA) and a ferredoxin reductase (KshB). The oxygenase contains a Rieske-type iron-sulfur center and non-heme iron. The reductase component is a flavoprotein containing an NAD-binding domain and a plant-type iron-sulfur cluster. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione." +"1.14.13.143",This cytochrome P-450 (heme thiolate) enzyme has been characterized from the plant Oryza sativa (rice). It may be involved in production of oryzadione. +"1.14.13.144","Requires cytochrome P-450. A rice, Oryza sativa, enzyme involved in the phytoalexin momilactone biosynthesis. It also acts similarly on 9beta-stemod-13(17)-ene." +"1.14.13.145","Requires cytochrome P450. A rice, Oryza sativa, enzyme involved in the biosynthesis of the antifungal phytocassanes." +"1.14.13.146","Requires cytochrome P450. From the yew Taxus cuspidata. Also acts on taxa-4(20),11-dien-5alpha-yl acetate." +"1.14.13.147",Requires cytochrome P-450. From the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis. +"1.14.13.148","A flavoprotein. The bacterial enzyme enables bacteria to use trimethylamine as the sole source of carbon and energy [1,4]. The mammalian enzyme is involved in detoxification of trimethylamine. Mutations in the human enzyme cause the inheritable disease known as trimethylaminuria (fish odor syndrome) [2,3]." +"1.14.13.149",Part of the aerobic pathway of phenylacetate catabolism in Escherichia coli and Pseudomonas putida. +"1.14.20.2","The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses)." +"2.1.1.239","The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus. It can also act on other monoglycosylated macrolactones, including L-rhamnosyl-erythronolide B and L-mycarosyl-erythronolide B. " +"2.1.1.240",The enzyme catalyses the biosynthesis of pterostilbene from resveratrol. +"2.1.1.241","The enzyme is involved in the biosynthesis of the protective and allelophatic benzoxazinoid DIMBOA [(2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin] in some plants, most commonly from the family of Poaceae (grasses)." +"2.1.1.242",The enzyme specifically methylates guanine1516 at N2 in 16S rRNA. +"2.3.1.197","The product, dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose, is a component of the glycan chain of the crystalline bacterial cell surface layer protein (S-layer glycoprotein) of Aneurinibacillus thermoaerophilus." +"2.4.1.278",The enzyme is involved in erythromycin biosynthesis. +"2.5.1.98","The enzyme is responsible for pyruvylation of the subterminal glucose in the acidic octasaccharide repeating unit of the exopolysaccharide of Rhizobium leguminosarum (bv. viciae strain VF39) which is necessary to establish nitrogen-fixing symbiosis with Pisum sativum, Vicia faba, and Vicia sativa." +"2.7.7.81",Mg2+ is required for activity. +"3.1.7.10","The enzyme from the lycophyte Selaginella moellendorffii is bifunctional, initially forming (13E)-labda-7,13-dien-15-yl diphosphate, which is hydrolysed to the alcohol." +"3.4.19.14","The mouse enzyme is specific for leukotriene C4, while the human enzyme also has considerable activity towards glutathione and oxidized glutathione (cf. EC 3.4.19.13, glutathione hydrolase) [3-4]." +"3.5.4.32","Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions. +" +"3.6.1.58","The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [1,2]. Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase) [4]. The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate [6]." +"3.6.1.59","The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] [4]. +" +"3.6.1.60","A divalent cation is essential for activity. Mn2+ (2--6 mM) is most effective. +The enzyme controls intracellular levels of P1,P5-bis(5'-adenosyl)pentaphosphate and P1,P6-bis(5'-adenosyl)hexaphosphate. Weak activity with P1,P4-bis(5'-adenosyl)tetraphosphate. Marked preference for adenine over guanine nucleotides. " +"3.6.1.61","The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5'-guanosyl) tetraphosphate very slowly [cf. EC 3.6.1.17, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)]. " +"3.6.1.62",Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ [5]. +"3.7.1.17","The enzyme is involved in the bacterial degradation of the steroid ring structure, and is involved in degradation of multiple steroids, such as testosterone [1], cholesterol [2], and sitosterol. " +"4.2.3.94",One of five sesquiterpenoid synthases in Pogostemon cablin (patchouli). +"4.2.3.95",The enzyme from the fungus Coprinopsis cinerea produces (-)-alpha-cuprenene with high selectivity. +"4.2.3.96","Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained." +"4.2.3.97","The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. Following a 1,3-hydride shift of the original 1-pro-S hydrogen of (2E,6E)-farnesyl diphosphate, cyclization and deprotonation gives (-)-delta-cadinene." +"4.2.3.98","The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. After a 1,3-hydride shift of the original 1-pro-S hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T-muurolol." +"4.2.3.99","The enzyme from rice (Oryza sativa), expressed in Escherichia coli, also produces ent-sandaracopimara-8(14),15-diene from ent-copalyl diphosphate, another naturally occuring copalyl isomer in rice (cf. ent-sandaracopimaradiene synthase, EC 4.2.3.29)." +"4.2.3.100",The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor. With Mg2+ a more complex mixture is produced. +"4.2.3.101","The enzyme from Zea mays, variety B73, gives mainly 7-epi-sesquithujene with (S)-beta-bisabolene and traces of other sesquiterpenoids, cf. EC 4.2.3.55 (S)-beta-bisabolene synthase. It requires Mg2+ or Mn2+. The product ratio is dependent on which metal ion is present. 7-epi-Sesquithujene is an attractant for the emerald ash borer beetle." +"4.2.3.102","The enzyme from Zea mays, variety Delprim, gives mainly sesquithujene with (S)-beta-bisabolene and (E)-beta-farnesene plus traces of other sesquiterpenoids, cf. EC 4.2.3.55 [(S)-beta-bisabolene synthase] and EC 4.2.3.47 (beta-farnesene synthase). It requires Mg2+ or Mn2+. The exact product ratio is dependent on which metal ion is present. " +"4.2.3.103","Two enzymes of the rice sub-species Oryza sativa ssp. indica, OsKSL5 and OsKSL6, produce ent-isokaurene. A variant of OsKSL5 from the sub-species Oryza sativa ssp. japonica produces ent-pimara-8(14),15-diene instead [cf. EC 4.2.3.30, ent-pimara-8(14),15-diene synthase]." +"4.2.3.104","The enzyme from Zingiber zerumbet, shampoo ginger, also gives traces of beta-caryophyllene. +" +"5.4.99.57",The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids. +"1.1.1.318","The enzyme acts in the opposite direction. The enzymes from the plants Ocimum basilicum (sweet basil) [1,3], Clarkia breweri and Petunia hybrida [4] only accept coniferyl acetate and form eugenol. The enzyme from Pimpinella anisum (anise) forms anol (from 4-coumaryl acetate) in vivo, although the recombinant enzyme can form eugenol from coniferyl acetate [5]. The enzyme from Larrea tridentata (creosote bush) also forms chavicol from a coumaryl ester and can use NADH [2]." +"1.1.1.319","The enzyme acts in the opposite direction. In Ocimum basilicum (sweet basil), Clarkia breweri and Petunia hybrida only isoeugenol is formed [1,2]. However in Pimpinella anisum (anise) only anol is formed in vivo, although the cloned enzyme does produce isoeugenol [3]." +"1.1.1.320","The enzyme also reduces 1-phenylpropane-1,2-dione. The enzyme from Bacillus cereus in addition reduces 1,4-naphthoquinone and 1-(4-methylphenyl)-2-phenylethane-1,2-dione with high efficiency [2]." +"1.1.1.321",The enzyme from the bacterium Xanthomonas oryzae is able to reduce enantioselectively only one of the two carbonyl groups of benzil to give optically active (R)-benzoin. +"1.1.1.322",Isolated from the plant Foeniculum vulgare (fennel). NADH is slightly preferred to NADPH. +"1.1.1.323",Isolated from the plant Tanacetum vulgare (tansy). NADH is preferred to NADPH. +"1.1.1.324","Contains Zn2+. The enzyme catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol. Also acts on geraniol, nerol and citronellol. May be identical to EC 1.1.1.183 geraniol dehydrogenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol as used by references 1 and 2. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}." +"1.1.1.325","This enzyme, isolated from the bacterium Chlorobium tepidum, catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. cf. EC 1.1.1.153, sepiapterin reductase (L-erythro-7,8-dihydrobiopterin-forming)." +"1.1.1.326","The enzyme was cloned from shampoo ginger, Zingiber zerumbet." +"1.3.8.3","Contains a tightly-bound FAD cofactor. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor. " +"1.3.8.4",Contains a tightly-bound FAD cofactor. Pentanoate can act as donor. +"1.3.99.32","The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site." +"1.14.13.150",Requires cytochrome P-450. The recommended numbering of humulene gives 10-hydroxy-alpha-humulene as the product rather than 8-hydroxy-alpha-humulene as used by the reference. See {iupac/sectionF/index::Section F: Natural Product Nomenclature}. +"1.14.13.151",A heme-thiolate protein (P-450). The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain. +"1.14.13.152","Requires cytochrome P-450. Also hydroxylates nerol and citronellol, cf. EC 1.14.13.151 linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}. The cloned enzyme also catalysed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.13.21, flavonoid 3'-monooxygenase) [3]." +"1.14.13.153",Requires cytochrome P-450. The enzyme has been characterized from Salvia officinalis (sage). +"1.14.13.154","The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B [1]. " +"1.14.99.46","The enzyme participates in the Rut pyrimidine catabolic pathway. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule." +"1.17.2.2",The enzyme isolated from Pseudomonas putida contains heme c and requires pyrroloquinoline quinone (PQQ) for activity +"2.1.1.243",The enzyme is involved in production of the rare amino acid (3R)-3-methyl-L-arginine. The compound is used by the epiphytic bacterium Pseudomonas syringae pv. syringae as an antibiotic against the related pathogenic species Pseudomonas savastanoi pv. glycinea. Other bacteria incorporate the compound into more complex compounds such as the peptidyl nucleoside antibiotic arginomycin. +"2.1.1.244","This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. When the terminal amino acid is L-proline, the enzyme catalyses two successive methylations of its alpha-amino group. When the first amino acid is either L-alanine or L-serine, the enzyme catalyses three successive methylations. +The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids [1,2]." +"2.1.1.245","Catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin. Forms, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase, and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, the acetyl-CoA decarbonylase/synthase complex that catalyses the demethylation of acetyl-CoA in a reaction that also forms CO2. This reaction is a key step in methanogenesis from acetate." +"2.1.1.246","The enzyme, which is involved in methanogenesis from methanol, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.90, methanol---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis. Free methylcob(I)alamin can substitute for the corrinoid protein in vitro [5]." +"2.1.1.247","Contains zinc [2]. The enzyme, which is involved in methanogenesis from mono-, di-, and trimethylamine, catalyses the transfer of a methyl group bound to the cobalt cofactor of several corrinoid proteins (mono-, di-, and trimethylamine-specific corrinoid proteins, cf. EC 2.1.1.248, methylamine---corrinoid protein Co-methyltransferase, EC 2.1.1.249, dimethylamine---corrinoid protein Co-methyltransferase, and EC 2.1.1.250, trimethylamine---corrinoid protein Co-methyltransferase) to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis." +"2.1.1.248","The enzyme, which catalyses the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase." +"2.1.1.249","The enzyme, which catalyses the transfer of a methyl group from dimethylamine to a dimethylamine-specific corrinoid protein (MtbC), is involved in methanogenesis from dimethylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase." +"2.1.1.250","The enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine. The enzyme contains the unusual amino acid pyrrolysine [2]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase." +"2.1.1.251","The enzyme, which is involved in methanogenesis from methylated thiols, such as methane thiol, dimethyl sulfide, and 3-(methylsulfanyl)propanoate, catalyses two successive steps - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to CoM. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90, methanol---corrinoid protein Co-methyltransferase, and EC 2.1.1.246, [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation." +"2.1.1.252","The enzyme, which catalyses the transfer of a methyl group from tetramethylammonium to a tetramethylammonium-specific corrinoid protein (MtqC), is involved in methanogenesis from tetramethylammonium. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.253, methylated tetramethylammonium-specific corrinoid protein:coenzyme M methyltransferase." +"2.1.1.253","The enzyme, which is involved in methanogenesis from tetramethylammonium, catalyses the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.252, tetramethylammonium---corrinoid protein Co-methyltransferase), where it is bound to the cobalt cofactor, to CoM, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, the enzyme that catalyses the final step in methanogenesis." +"2.1.1.254","The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154, erythromycin 12 hydroxylase." +"2.1.1.255","This enzyme, along with EC 4.2.3.118, 2-methylisoborneol synthase, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odour." +"2.4.1.279","The enzymes from Clostridium phytofermentans is specific for nigerose, and shows only 0.5% relative activity with kojibiose (cf. EC 2.4.1.230, kojibiose phosphorylase)." +"2.4.1.280","The enzyme is specific for N,N'-diacetylchitobiose and does not phosphorylate other N-acetylchitooligosaccharides, cellobiose, trehalose, lactose, maltose or sucrose. " +"2.4.1.281",This enzyme forms part of a mannan catabolic pathway in the anaerobic bacterium Bacteroides fragilis NCTC 9343. +"2.4.99.16",The enzyme from the bacterium Mycobacterium smegmatis is specific for maltose. It has no activity with alpha-D-glucose. +"2.7.1.173",The enzyme from yeast and human also has the activity of EC 2.7.1.22 (ribosylnicotinamide kinase). +"2.7.1.174","Requires Ca2+ or Mg2+ for activity. Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals [cf. EC 2.7.1.107, diacylglycerol kinase (ATP)], the enzyme from Saccharomyces cerevisiae utilizes CTP. The enzyme can also use dCTP, but not ATP, GTP or UTP. " +"2.7.1.175",Requires Mg2+ for activity. +"2.7.1.176","Toxic component of a toxin-antitoxin (TA) module. The phosphorylation of UDP-N-acetyl-D-glucosamine results in the inhibition of EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, the first committed step in cell wall synthesis, which is then blocked. The activity of this enzyme is inhibited when the enzyme binds to the cognate epsilon antitoxin." +"3.1.3.87","The enzyme participates in the methionine salvage pathway in Bacillus subtilis [2]. In some species a single bifunctional enzyme, EC 3.1.3.77, acireductone synthase, catalyses both this reaction and EC 5.3.2.5, 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [1]." +"3.1.7.11",Isolated from Ocimum basilicum (basil) and Cinnamomum tenuipile (camphor tree). Requires Mg2+ or Mn2+. Geraniol is labelled when formed in the presence of [18O]H2O. Thus mechanism involves a geranyl cation [1]. Neryl diphosphate is hydrolysed more slowly. May be the same as EC 3.1.7.3 monoterpenyl-diphosphatase. +"3.5.1.110",The enzyme participates in the Rut pyrimidine catabolic pathway. +"3.5.1.135","The enzyme from the bacterium Escherichia coli is one of the smallest known monomeric amidohydrolases (103-amino acids). The enzyme is active towards a wide range of N4-acylcytosines/cytidines, but is by far most active against N4-acetylcytidine." +"4.1.1.94","The enzyme, which exists in all vertebrates, decarboxylates ethylmalonyl-CoA, a potentially toxic compound that is formed in low amounts by the activity of EC 6.4.1.2, acetyl-CoA carboxylase and EC 6.4.1.3, propionyl-CoA carboxylase. It prefers the S isomer, and can decarboxylate (R)-ethylmalonyl-CoA with lower efficiency. cf. EC 7.2.4.3, (S)-methylmalonyl-CoA decarboxylase (sodium-transporting)." +"4.1.2.50","Binds Zn2+. Isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine.The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin [2]." +"4.2.1.132","This enzyme catalyses a late step in the bacterial steroid degradation pathway. The product, 4-hydroxy-2-oxohexanoate, forms a 2-hydroxy-4-hex-2-enolactone under acidic conditions." +"4.2.3.105","The enzyme from Solanum lycopersicum (tomato) gives a mixture of tricyclene, camphene, beta-myrcene, limonene, and traces of several other monoterpenoids. See EC 4.2.3.117. (-)-camphene synthase, EC 4.2.3.15, myrcene synthase and EC 4.2.3.16, (4S)-limonene synthase." +"4.2.3.106","Widely distributed in plants, which release beta-ocimene when attacked by herbivorous insects." +"4.2.3.107","The enzyme reacts with (3S)-linalyl diphosphate twice as rapidly as geranyl diphosphate, but 25 times as rapidly as (3R)-linalyl diphosphate. It is assumed that (3S)-linalyl diphosphate is normally formed as an enzyme bound intermediate in the reaction. In the reaction the 5-pro-R hydrogen of geranyl diphosphate is eliminated during cyclopropane ring formation [1,2]. In Picea abies (Norway spruce) and Picea sitchensis (Sitka spruce) terpinolene is also formed [4,6]. See EC 4.2.3.113 terpinolene synthase. (+)-Car-3-ene is associated with resistance of Picea sitchensis (Sitka spruce) to white pine weevil [6]." +"4.2.3.108","Requires Mn2+ or Zn2+. Mg2+ is less effective than either. 1,8-Cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)-linalyl diphosphate [1-3] while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate [4]." +"4.2.3.109",Requires Mg2+. Isolated from Pinus contorta (lodgepole pine) as cyclase I [1] and from Conocephalum conicum (liverwort) [2]. +"4.2.3.110","Isolated from Salvia officinalis (sage). The recombinant enzyme gave 63% (+)-sabinene, 21% gamma-terpinene, and traces of other monoterpenoids. See EC 4.2.3.114 gamma-terpinene synthase." +"4.2.3.111","The enzyme has been characterized from Vitis vinifera (grape). Also forms some 1,8-cineole and traces of other monoterpenoids." +"4.2.3.112",The enzyme has been characterized from Santalum album (sandalwood). Also forms some (-)-limonene and traces of other monoterpenoids. See EC 4.2.3.16 (4S)-limonene synthase. +"4.2.3.113","Requires Mg2+. Mn2+ is less effective and product ratio changes. Forms traces of other monoterpenoids. +" +"4.2.3.114","Isolated from Thymus vulgaris (thyme) [1,2], Citrus limon (lemon) [3], Citrus unshiu (satsuma) [4] and Origanum vulgare (oregano) [5]. Requires Mg2+. Mn2+ less effective. The reaction involves a 1,2-hydride shift. The 5-pro-S hydrogen of geranyl diphosphate is lost. Traces of several other monoterpenoids are formed in addition to gamma-terpinene." +"4.2.3.115","The enzyme has been characterized from Dysphania ambrosioides (American wormseed). Requires Mg2+. Mn2+ is less effective. The enzyme will also use (3R)-linalyl diphosphate. The reaction involves a 1,2-hydride shift. The 1-pro-S hydrogen of geranyl diphosphate is lost." +"4.2.3.116",Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-camphene and (+)-alpha-pinene. (3R)-Linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. Requires Mg2+ (preferred to Mn2+). See also EC 4.2.3.121 (+)-alpha-pinene synthase. +"4.2.3.117","(-)-Camphene is the major product in Abies grandis (grand fir) with traces of other monoterpenoids [1]. In Pseudotsuga menziesii (Douglas-fir) there are about equal parts of (-)-camphene and (-)-alpha-pinene with traces of four other monoterpenoids [2,3]. In Solanum lycopersicum (tomato) tricyclene, beta-myrcene, limonene, and traces of several other monoterpenoids are also formed [4]. See also EC 4.2.3.15 myrcene synthase, EC 4.2.3.16 (4S)-limonene synthase, EC 4.2.3.119 (-)-alpha-pinene synthase and EC 4.2.3.105 tricyclene synthase." +"4.2.3.118","The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms." +"4.2.3.119","Cyclase II of Salvia officinalis (sage) gives about equal parts (-)-alpha-pinene, (-)-beta-pinene and (-)-camphene, plus traces of other monoterpenoids. (3S)-Linalyl diphosphate can also be used by the enzyme in preference to (3R)-linalyl diphosphate. The 4-pro-S-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+) [1-6]. The enzyme from Abies grandis (grand fir) gives roughly equal parts (-)-alpha-pinene and (-)-beta-pinene. However the clone ag11 gave 35% (-)-limonene, 24% (-)-alpha-pinene and 20% (-)-beta-phellandrene. It requires Mn2+ and K+ (Mg2+ is ineffective) [7-10]. Synthase I from Pinus taeda (loblolly pine) produces (-)-alpha-pinene with traces of (-)-beta-pinene and requires Mn2+ (preferred to Mg2+) [11,12]. The enzyme from Picea sitchensis (Sika spruce) forms 70% (-)-alpha-pinene and 30% (-)-beta-pinene [13]. The recombinant PmeTPS1 enzyme from Pseudotsuga menziesii (Douglas fir) gave roughly equal proportions of (-)-alpha-pinene and (-)-camphene plus traces of other monoterpenoids [14]. See also EC 4.2.3.120, (-)-beta-pinene synthase; EC 4.2.3.117, (-)-camphene synthase; EC 4.2.3.16, (-)-limonene synthase; and EC 4.2.3.52, (-)-beta-phellandrene synthase." +"4.2.3.120","Cyclase II of Salvia officinalis (sage) produces about equal parts (-)-alpha-pinene, (-)-beta-pinene and (-)-camphene, plus traces of other monoterpenoids. The enzyme, which requires Mg2+ (preferred to Mn2+), can also use (3S)-Linalyl diphosphate (preferred to (3R)-linalyl diphosphate) [1-4]. The enzyme from Abies grandis (grand fir) produces roughly equal parts of (-)-alpha-pinene and (-)-beta-pinene [6-9]. Cyclase IV from Pinus contorta (lodgepole pine) produces 63% (-)-beta-pinene, 26% 3-carene, and traces of alpha-pinene [10]. Synthase III from Pinus taeda (loblolly pine) forms (-)-beta-pinene with traces of alpha-pinene and requires Mn2+ and K+ (Mg2+ is ineffective) [11]. A cloned enzyme from Artemisia annua (sweet wormwood) gave (-)-beta-pinene with traces of (-)-alpha-pinene [5]. The enzyme from Picea sitchensis (Sika spruce) forms 30% (-)-beta-pinene and 70% (-)-alpha-pinene [12]. See also EC 4.2.3.119, (-)-alpha-pinene synthase, EC 4.2.3.117, (-)-camphene synthase, and EC 4.2.3.107 (+)-3-carene synthase." +"4.2.3.121","Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-alpha-pinene and (+)-camphene, whereas cyclase III gives about equal parts of (+)-alpha-pinene and (+)-beta-pinene. (3R)-Linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. The 4-pro-R-hydrogen of geranyl diphosphate is lost. Requires Mg2+ (preferred to Mn2+) [1-4]. With synthase II of Pinus taeda (loblolly pine) (+)-alpha-pinene was the only product [5,6]. Requires Mn2+ (preferred to Mg2+). See also EC 4.2.3.122, (+)-beta-pinene synthase, and EC 4.2.3.116, (+)-camphene synthase." +"4.2.3.122","Cyclase III from Salvia officinalis (sage) gives roughly equal parts of (+)-beta-pinene and (+)-alpha-pinene. See EC 4.2.3.121, (+)-alpha-pinene synthase. " +"5.3.2.5","The enzyme participates in the methionine salvage pathway in Bacillus subtilis [2].In some species a single bifunctional enzyme, EC 3.1.3.77, acireductone synthase, catalyses both this reaction and EC 3.1.3.87, 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [1]." +"5.3.99.10","The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate." +"6.3.4.20",Binds Zn2+. The reaction is part of the biosynthesis pathway of queuosine. +"1.1.1.327","Contains Zn2+. Isolated from Pseudomonas putida, and involved in degradation of (+)-camphor." +"1.3.1.92",Cloned from Artemisia annua. In addition to the reduction of artemisinic aldehyde it is also able to a lesser extent to reduce artemisinic alcohol and artemisinic acid. Part of the biosyntheis of artemisinin. +"1.3.8.5","A flavoprotein (FAD). The mammalian enzyme catalyses an oxidative reaction as a step in the mitochondrial beta-oxidation of short-chain 2-methyl fatty acids and participates in isoleucine degradation. The enzyme from the parasitic helminth Ascaris suum catalyses a reductive reaction as part of a fermentation pathway, shuttling reducing power from the electron-transport chain to 2-methyl branched-chain enoyl CoA." +"1.3.8.6","Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 7.2.4.5, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA [EC 1.3.99.32, glutaryl-CoA dehydrogenase (acceptor)]." +"1.3.8.7","Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds [2]. The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase." +"1.3.8.8","Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively [2]. The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase." +"1.3.8.9","Contains a tightly-bound FAD cofactor. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase." +"1.4.1.23","The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)]." +"1.13.11.63","Requires Fe2+. The enzyme cleaves beta-carotene symmetrically, producing two molecules of all-trans-retinal. Both atoms of the oxygen molecule are incorporated into the products [8]. The enzyme can also process beta-cryptoxanthin, 8'-apo-beta-carotenal, 4'-apo-beta-carotenal, alpha-carotene and gamma-carotene in decreasing order. The presence of at least one unsubstituted beta-ionone ring in a substrate greater than C(30) is mandatory [5]. A prokaryotic enzyme has been reported from the uncultured marine bacterium 66A03, where it is involved in the proteorhodopsin system, which uses retinal as its chromophore [6,7]." +"1.14.13.155",Involved in the catabolism of alpha-pinene. +"1.14.13.156","A heme-thiolate protein (P-450) which uses a flavodoxin-like redox partner to reduce the heme iron. Isolated from the bacterium Citrobacter braakii, which can use 1,8-cineole as the sole source of carbon." +"1.14.13.157","A heme-thiolate protein (P-450). The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.13.97 (taurochenodeoxycholate 6-hydroxylase), EC 1.14.13.67 (quinine 3-monooxygenase) and EC 1.14.13.32 (albendazole monooxygenase)." +"1.14.13.158",A heme-thiolate protein (P-450). Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin. +"1.14.13.159","A microsomal enzyme isolated from human and mouse liver which bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4]." +"1.14.13.160",A FAD dependent enzyme isolated from Pseudomonas putida. Forms part of the catabolism pathway of camphor. It acts on the CoA ester in preference to the free acid. +"1.14.13.161",A cytochrome P-450 monooxygenase isolated from Salvia officinalis (sage). Involved in the catabolism of camphor in senescent tissue. +"1.14.13.162","A flavoprotein (FMN) which requires Fe2+. A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid. Involved in the degradation of (+)-camphor. Requires a dedicated NADH-FMN reductase [cf. EC 1.5.1.42, FMN reductase (NADH)] [1-3]. Can accept several bicyclic ketones including (+)- and (-)-camphor [6] and adamantanone [4]. The product spontaneously converts to [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate." +"1.14.15.9","The enzyme is involved in spheroidenone biosynthesis and in 2,2'-dioxospirilloxanthin biosynthesis. The enzyme from Rhodobacter sphaeroides contains heme at its active site [1]. " +"1.14.15.10",A cytochrome P-450 monooxygenase from the bacterium Rhodococcus sp. NCIMB 9784. +"1.18.1.5","Requires FAD. The enzyme from Pseudomonas putida reduces putidaredoxin. It contains a [2Fe-2S] cluster. Involved in the camphor monooxygenase system (see EC 1.14.15.1, camphor 5-monooxygenase)." +"2.1.1.256",The enzyme specifically methylates guanine6 at N2 in tRNA. +"2.1.1.257","While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54 [2,3]." +"2.2.1.10","The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase." +"2.2.1.11","The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase." +"2.3.1.198",A membrane-associated enzyme required for suberin or cutin synthesis in plants. Active with a wide range of acyl-CoA substrates (C16:0-C24:0). The enzyme from some sources has much higher activity with omega-oxidized acyl-CoAs. Some enzymes are bifunctional and have an additional phosphatase activity producing sn-2-monoacylglycerols. +"3.7.1.18","Isolated from Rhodococcus sp. The bornane ring system is cleaved by a retro-Claisen reaction to give the enol of alpha-campholonate. When separate from the enzyme the enol is tautomerised to the keto form as a 6:1 mixture of [(1S,3R)-2,2,3-trimethyl-4-oxocyclopentyl]acetate and [(1S,3S)-2,2,3-trimethyl-4-oxocyclopentyl]acetate." +"4.2.1.133",Requires Mg2+. The enzyme was characterized from the plant Cistus creticus subsp. creticus. +"4.2.3.124","Requires Co2+ [2]. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Requires an NAD+ cofactor, which is transiently reduced during the reaction [1,4]. The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex [6,7]." +"4.2.3.125","The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and gamma-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.126, gamma-muurolene synthase. +" +"4.2.3.126","The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and alpha-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.125, alpha-muurolene synthase." +"4.2.3.127","Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-cubebene, (+)-sativene and traces of several other sequiterpenoids [1-3]. beta-Copaene is formed in the presence of Mg2+ but not Mn2+ [2]. See EC 4.2.3.13, (+)-delta-cadinene synthase, EC 4.2.3.128, beta-cubebene synthase, and EC 4.2.3.129, (+)-sativene synthase." +"4.2.3.128","Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-copaene, (+)-sativene and traces of several other sequiterpenoids [2-4]. It is found in many higher plants such as Magnolia grandiflora (Southern Magnolia) together with germacrene A [1]. See EC 4.2.3.13, (+)-delta-cadinene synthase, EC 4.2.3.127, beta-copaene synthase, EC 4.2.3.129, (+)-sativene synthase, and EC 4.2.3.23, germacrene A synthase. " +"4.2.3.129","Isolated from the fungus Coprinus cinereus. The enzyme also forms (+)-delta-cadinene, beta-copaene, beta-cubebene, and traces of several other sequiterpenoids. See EC 4.2.3.13, (+)-delta-cadinene synthase, EC 4.2.3.127, beta-copaene synthase, and EC 4.2.3.128, beta-cubebene synthase." +"4.2.3.130",Isolated from Bacillus subtilis. This sesquarterpene is present in a number of Bacillus species. +"4.3.99.3",Requires Mg2+. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine. +"6.2.1.38",Isolated from Pseudomonas putida. Forms part of the pathway of camphor catabolism. +"1.1.1.328","The enzyme, characterized from the nicotine degrading bacterium Arthrobacter nicotinovorans, catalyses the reduction of ""nicotine blue"" to its hydroquinone form (the opposite direction from that shown). Nicotine blue is the name given to the compound formed by the autocatalytic condensation of two molecules of 2,3,6-trihydroxypyridine, an intermediate in the nicotine degradation pathway. The main role of the enzyme may be to prevent the intracellular formation of nicotine blue semiquinone radicals, which by redox cycling would lead to the formation of toxic reactive oxygen species. The enzyme possesses a slight preference for NADH over NADPH." +"1.1.1.329","Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC 1.1.99.38, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)." +"1.1.1.330","The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase." +"1.1.1.331",Isolated from the plants Forsythia intermedia [1] and Podophyllum peltatum [1-3]. An intermediate lactol is detected in vitro. +"1.1.1.332",The enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi. +"1.1.1.333","The reaction is catalysed in the reverse direction. The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.98.3, decaprenylphospho-beta-D-ribofuranose 2-oxidase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers." +"1.1.1.334","The enzyme from the plant Erythroxylum coca catalyses the penultimate step in the biosynthesis of cocaine. In vivo the reaction proceeds in the opposite direction. With NADH instead of NADPH the reaction rate is reduced to 14%. The enzyme also reduces tropinone, nortropinone and 6-hydroxytropinone but with lower reaction rates." +"1.1.3.43","Contains FAD. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Works in combination with EC 2.6.1.93, neamine transaminase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase." +"1.1.3.44","Contains FAD. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 2.6.1.95, neomycin C transaminase, to replace the 6'''-hydroxy group of 6'''-hydroxyneomycin C with an amino group. +Also catalyses EC 1.1.3.43, paromamine 6'-oxidase." +"1.1.98.3","The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.1.333, decaprenylphospho-D-erythro-pentofuranosid-2-ulose 2-reductase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers." +"1.1.99.38","Involved in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family. The enzyme from Bacillus circulans was shown to be a radical S-adenosyl-L-methionine (SAM) enzyme. cf. EC 1.1.1.329, 2-deoxy-scyllo-inosamine dehydrogenase." +"1.2.1.83",The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway. +"1.2.1.84","The enzyme has a wide distribution and is found in bacteria, plants, fungi, and animals. The alcohol is formed by a four-electron reduction of fatty acyl-CoA. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. Enzymes from different sources vary in their chain-length preference. cf. EC 1.2.1.108, alcohol-forming fatty acyl-CoA reductase (NADH)." +"1.3.1.93","This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase." +"1.3.1.94","The enzyme, isolated from human fetal brain tissue but present in all eukaryotes, catalyses the reduction of the terminal double bond next to the aldehyde group in ditrans,polycis-polyprenal, as part of the pathway that produces dolichol. In mammalian cells dolichols are predominantly 18-21 isoprene units in length." +"1.4.3.24","Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacterium Pseudomonas sp. HZN6, is involved the nicotine degradation." +"1.5.3.19",A flavoprotein (FAD). In the enzyme from the soil bacterium Arthrobacter nicotinovorans the cofactor is covalently bound. Participates in the nicotine degradation pathway of this organism. +"1.5.3.20","Isolated from the mold Cladosporium sp. G-10. Acts on N6-(carboxymethyl)lysine, 6-[(carboxymethy)amino]hexanoic acid, sarcosine and N-ethylglycine. It has negligible action on glycine (cf. EC 1.4.3.19 glycine oxidase)." +"1.5.3.21",The enzyme participates in the nicotine degradation pathway of the soil bacterium Arthrobacter nicotinovorans. Has a very weak monoamine oxidase (EC 1.4.3.4) activity with 4-aminobutanoate [1]. +"1.5.99.14","Contains a cytidylyl molybdenum cofactor [3]. The enzyme, which participates in the nicotine degradation pathway, has been characterized from the soil bacterium Arthrobacter nicotinovorans [1,2]." +"1.13.11.64","The enzyme, characterized from the soil bacterium Bradyrhizobium sp. JS329, is involved in the pathway of 5-nitroanthranilate degradation. It is unusual in being able to catalyse the ring fission without the requirement for prior removal of the nitro group. The product undergoes spontaneous lactonization, with concurrent elimination of the nitro group." +"1.14.13.163",The enzyme catalyses a reaction in the nicotine degradation pathway of Pseudomonas species. One of the enzymes from the soil bacterium Pseudomonas putida S16 contains an FAD cofactor [2]. +"1.14.13.164","The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary carotenoids in insects. The enzyme accepts different all-trans carotenoids, including beta-carotene, alpha-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule." +"1.14.13.165","Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. Most of the bacterial and archaeal enzymes consist of only an oxidase domain and function together with bacterial ferredoxins [1-2]. The enzyme from the delta-proteobacterium Sorangium cellulosum also includes a reductase domain that binds FAD, FMN and a [2Fe-2S] cluster [3]. The similar enzymes from plants and animals use only NADPH as acceptor (cf. EC 1.14.13.39)." +"1.14.14.13","Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. FMNH2 is used as a free cofactor. Forms a complex with a dedicated NAD(P)H:FMN oxidoreductase. The enzyme is not able to hydroxylate free substrates, activation by the acyl-carrier protein is mandatory. +Octanoyl-S-[BtrI acyl-carrier protein] is also accepted." +"2.1.1.258","Catalyses the transfer of a methyl group from the N5 group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. Involved, together with EC 1.2.7.4, anaerobic carbon-monoxide dehydrogenase and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea." +"2.1.1.259","The enzyme methylates a conserved lysine in the C-terminal part of higher plant fructose-bisphosphate aldolase (EC 4.1.2.13). The enzyme from pea (Pisum sativum) also methylates Lys-14 in the large subunits of hexadecameric higher plant ribulose-bisphosphate-carboxylase (EC 4.1.1.39) [2], but that from Arabidopsis thaliana does not." +"2.3.1.199","This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids [6,7]. For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate [5], while CER6 from the same plant prefers substrates with chain length of C22 to C32 [4,8]. cf. EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase" +"2.3.1.200","In the bacterium Listeria monocytogenes the enzyme takes part in a pathway for scavenging of lipoic acid. The enzyme is bound to 2-oxo-acid dehydrogenases such as the pyruvate dehydrogenase complex, where it transfers the lipoyl moiety from lipoyl-[glycine cleavage system H] to the E2 subunits of the complexes." +"2.3.1.201","This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide." +"2.3.1.202",Isolated from Helicobacter pylori. The enzyme is involved in the biosynthesis of pseudaminic acid. +"2.3.1.203","The product, UDP-N,N'-diacetylbacillosamine, is an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [1,2] and O-linked glycosylation of certain L-serine residues in Neisseria species [3]." +"2.3.2.19",The enzyme attaches the side chain of the aminoglycoside antibiotics of the butirosin family. The side chain confers resistance against several aminoglycoside-modifying enzymes. +"2.4.1.282","The enzyme does not phosphorylate alpha,alpha-trehalose, kojibiose, nigerose, or maltose. In the reverse phosphorolysis reaction the enzyme is specific for L-rhamnose as acceptor and beta-D-glucose 1-phosphate as donor." +"2.4.1.283","Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Unlike the enzyme from the bacterium Streptomyces kanamyceticus, which can also accept UDP-D-glucose [2] (cf. EC 2.4.1.284, 2-deoxystreptamine glucosyltransferase), the enzyme from Bacillus circulans can only accept UDP-N-acetyl-alpha-D-glucosamine [1]." +"2.4.1.284","Involved in the biosynthesis of kanamycin B and kanamycin C. Also catalyses EC 2.4.1.283, 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase, but activity is only one fifth of that with UDP-alpha-D-glucose." +"2.4.1.285","Involved in biosynthesis of the aminoglycoside antibiotic neomycin. Requires a divalent metal ion, optimally Mg2+, Mn2+ or Co2+." +"2.4.1.286","Isolated from the plant Antirrhinum majus (snapdragon). Involved in the biosynthesis of aurones, plant flavonoids that provide yellow color to the flowers." +"2.4.1.287","Isolated from the bacteria Mycobacterium tuberculosis and M. smegmatis, the enzyme has dual beta-(1->4) and beta-(1->5) transferase action. Involved in the formation of the cell wall in mycobacteria." +"2.4.1.288",Isolated from Mycobacterium tuberculosis. The enzyme adds approximately twenty-eight galactofuranosyl residues with alternating 1->5 and 1->6 links forming a galactan domain with approximately thirty galactofuranosyl residues. Involved in the formation of the cell wall in mycobacteria. +"2.4.2.45",Requires Mg2+. Isolated from Mycobacterium tuberculosis. Has some activity with other polyprenyl phosphates. +"2.4.2.46",Isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum. These arabinofuranosyl groups form the start of an arabinofuranan chain as part of the of the cell wall in mycobacteria. +"2.4.2.47",Isolated from Mycobacterium smegmatis. Involved in the formation of the cell wall in mycobacteria. +"2.4.99.17","The reaction is a combined transfer and isomerization of the ribose moiety of S-adenosyl-L-methionine to the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. It is part of the queuosine biosynthesis pathway." +"2.6.1.93","The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin and ribostamycin. Works in combination with EC 1.1.3.43, paromamine 6-oxidase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces kanamyceticus can also catalyse EC 2.6.1.94, 2'-deamino-2'-hydroxyneamine transaminase, which leads to production of kanamycin A [3]. The enzyme from the bacterium Streptomyces fradiae can also catalyse EC 2.6.1.95, leading to production of neomycin C [2]." +"2.6.1.94","The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of kanamycin A and kanamycin D. The enzyme, characterized from the bacterium Streptomyces kanamyceticus, can also catalyse EC 2.6.1.93, neamine transaminase." +"2.6.1.95","The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase, to replace the 6'''-hydroxy group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group. +The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC 2.6.1.93, neamine transaminase." +"2.7.1.177","The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP." +"2.7.4.26","The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as prenyl phosphate, geranyl phosphate, or fosfomycin. " +"2.7.8.35","Isolated from Mycobacterium tuberculosis and Mycobacterium smegmatis. This enzyme catalyses the synthesis of monotrans,octacis-decaprenyl-N-acetyl-alpha-D-glucosaminyl diphosphate (mycobacterial lipid I), an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. cf. EC 2.7.8.33, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase." +"3.1.1.91","This enzyme, characterized from the soil bacterium Bradyrhizobium sp. JS329, is involved in the pathway of 5-nitroanthranilate degradation." +"3.1.1.92",The enzyme was isolated from the bacteria Hydrogenophaga intermedia and Agrobacterium radiobacter S2. It catalyses a step in the degradation of 4-sulfocatechol. +"3.1.1.93","This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic." +"3.1.3.88","Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. No metal is required for activity." +"3.2.1.181","The enzyme from the fungus Flammulina velutipes (winter mushroom) hydrolyses the beta(1->3) bonds found in type II plant arabinogalactans, which occur in cell walls of dicots and cereals. The enzyme is an endohydrolase, and requires at least 3 contiguous beta-1,3-residues. cf. EC 3.2.1.89, arabinogalactan endo-beta-1,4-galactanase and EC 3.2.1.145, galactan 1,3-beta-galactosidase. +" +"3.5.99.9",The enzyme catalyses the initial step in the biodegradation of 2-nitroimidazole by the soil bacterium Mycobacterium sp. JS330 +"3.7.1.19","The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation." +"4.1.1.95",Binds pyridoxal 5'-phosphate. Catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. Has very low activity with substrates not bound to an acyl-carrier protein. +"4.1.1.96",A pyridoxal 5'-phosphate enzyme. Part of a bacterial polyamine biosynthesis pathway. The enzyme is essential for biofilm formation in the bacterium Vibrio cholerae [1]. The enzyme from Campylobacter jejuni only produces spermidine in vivo even though it shows activity with carboxynorspermidine in vitro [3]. +"4.2.3.131","Isolated from the plants Rosmarinus officinalis (rosemary) and Salvia miltiorrhiza. The enzyme from the plant Selaginella moellendorffii is mutifunctional and also catalyses EC 5.5.1.12, copalyl diphosphate synthase [2]." +"4.2.3.132","Isolated from Abies grandis (grand fir) [1]. This class I enzyme forms about equal proportions of abietadiene, levopimaradiene and neoabietadiene. See also EC 4.2.3.18, abieta-7,13-diene synthase and EC 4.2.3.32, levopimaradiene synthase. An X-ray study of this multifunctional enzyme showed that the class I activity is in the alpha domain, while (+)-copalyl diphosphate synthase activity (EC 5.5.1.12, a class II activity) is in the beta and gamma domains [2]. In Pinus taeda (loblolly pine) the major product is levopimaradiene, with less abietadiene and neoabietadiene [3]." +"4.2.3.133","Isolated from Helianthus annuus (sunflower). The enzyme also produces beta-caryophyllene, delta-cadinene and traces of other sesquiterpenoids. See EC 4.2.3.13 (+)-delta-cadinene synthase, EC 4.2.3.57 (-)-beta-caryophyllene synthase." +"4.3.2.6","The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the terminal gamma-L-glutamate of the side chain, releasing it as the cyclic 5-oxo-L-proline." +"5.3.2.6","Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. The enol form (2Z,4E)-2-hydroxyhexa-2,4-dienedioate is produced as part of this pathway and is converted to the keto form (3E)-2-oxohex-3-enedioate by the enzyme [6]. Another keto form, (4E)-2-oxohex-4-enedioate (4-oxalocrotonate), was originally thought to be produced by the enzyme [1,2] but later shown to be produced non-enzymically [5]." +"5.4.3.9","This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster, which is coordinated by 3 cysteines and binds an exchangeable S-adenosyl-L-methionine molecule. During the reaction cycle, the AdoMet forms a 5'-deoxyadenosyl radical, which is regenerated at the end of the reaction." +"6.2.1.39","Catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. The enzyme adds one molecule of L-glutamate to a dedicated acyl-carrier protein, and following decarboxylation of the product by EC 4.1.1.95, L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, adds a second L-glutamate molecule. +Requires Mg2+ or Mn2+, and activity is enhanced in the presence of Mn2+." +"6.3.2.38","Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme is believed to form an adenylate intermediate prior to ligation." +"6.3.2.39","Requires Mg2+. The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore. It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS). Type C enzymes are responsible for the formation of amide or ester bonds between a variety of substrates and a prochiral carboxyl group of a citrate molecule that is already linked to a different moiety at its other prochiral carboxyl group. The enzyme is believed to form an adenylate intermediate prior to ligation." +"1.1.1.335","This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalysing the next step the pathway (EC 2.6.1.98, UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase). The enzyme also possesses an EC 1.1.99.2 (L-2-hydroxyglutarate dehydrogenase) activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD+. The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD+ as tightly and do not require 2-oxoglutarate to function." +"1.1.1.336",Part of the pathway for acetamido sugar biosynthesis in bacteria and archaea. The enzyme has no activity with NADP+. +"1.1.1.337","The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates." +"1.1.1.338","The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate." +"1.1.1.339","The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+." +"1.1.1.340",Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis. +"1.1.1.341","Isolated from Yersinia pseudotuberculosis [1,3] and Salmonella enterica [1,2]." +"1.1.1.342","The enzyme is involved in synthesis of paratose and tyvelose, unusual 3,6-dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria. Isolated from Salmonella enterica subsp. enterica serovar Typhi (Salmonella typhi)." +"1.2.1.85","This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. Has lower activity with benzaldehyde [1]. Activity with NAD+ is more than 10-fold higher than with NADP+ [3]. cf. EC 1.2.1.32, aminomuconate-semialdehyde dehydrogenase." +"1.2.1.86",Does not act on neral. +"1.3.1.95","Contains FAD. The reaction is catalysed in the opposite direction to that shown. The enzyme from the bacterium Clostridium propionicum is a complex that includes an electron-transfer flavoprotein (ETF). The ETF is reduced by NADH and transfers the electrons to the active site. Catalyses a step in a pathway for L-alanine fermentation to propanoate [1]. cf. EC 1.3.1.84, acrylyl-CoA reductase (NADPH)." +"1.3.1.96","Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. cf. EC 2.5.1.21, squalene synthase, where squalene is formed directly from farnesyl diphosphate." +"1.3.1.97","Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. Involved in the production of botryococcenes, which are triterpenoid hydrocarbons of isoprenoid origin produced in large amount by this alga." +"1.3.7.10",A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. +"1.4.1.24","The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization." +"1.5.1.43","The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively [1]. The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation [2]. The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro [3]." +"1.5.1.44","The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The reaction proceeds in vivo in the opposite direction to the one shown here." +"1.5.1.45","This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and EC 1.14.14.8, anthranilate 3-monooxygenase (FAD). It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor. cf. EC 1.5.1.37, FAD reductase (NADH)." +"1.7.2.6","The enzymes from the nitrifying bacterium Nitrosomonas europaea [1,4] and the methylotrophic bacterium Methylococcus capsulatus [5] are hemoproteins with seven c-type hemes and one specialized P-460-type heme per subunit. The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate [3]. While nitrite is the main product, the enzyme from Nitrosomonas europaea can also produce nitric oxide by catalysing the activity of EC 1.7.2.9, hydroxylamine oxidase [2]." +"1.13.11.65","The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects. The enzyme accepts different all-trans carotenoids, including beta-carotene, alpha-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule." +"1.13.11.66","The enzyme is an extradiol-type dioxygenase, and is a member of the nonheme-iron(II)-dependent dioxygenase family. It catalyses the ring cleavage of a wide range of hydroquinone substrates to produce the corresponding 4-hydroxymuconic semialdehydes." +"1.13.11.67","A thiol-dependent enzyme isolated from rat and rabbit. Unlike EC 1.13.11.63, beta-carotene-15,15'-dioxygenase, it is not active towards beta-carotene. The secondary product has not been characterized, but may be (3E,5E)-7-hydroxy-6-methylhepta-3,5-dien-2-one." +"1.13.11.68","Requires Fe2+. The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza." +"1.13.11.69","Requires Fe2+. The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza. Also catalyses EC 1.13.11.70, all-trans-10'-apo-beta-carotenal 13,14-cleaving dioxygenase, but 10-fold slower." +"1.13.11.70","Requires Fe2+. The enzyme from the plant Arabidopsis thaliana also catalyses EC 1.13.11.69, carlactone synthase, 10-fold faster." +"1.13.11.71",Requires Fe2+. The enzyme catalyses the asymmetric oxidative cleavage of carotenoids. The mammalian enzyme can also cleave all-trans-lycopene. +"1.13.11.72",Requires non-heme-iron(II). Isolated from some bacteria including Streptomyces hygroscopicus and Streptomyces viridochromogenes. The pro-R hydrogen at C-2 of the ethyl group is retained by the formate ion. Any stereochemistry at C-1 of the ethyl group is lost. One atom from dioxygen is present in each product. Involved in phosphinothricin biosynthesis. +"1.13.11.73",Isolated from the marine archaeon Nitrosopumilus maritimus. +"1.14.11.35",The enzyme requires iron(II) and ascorbate. Isolated from the bacterium Streptomyces avermitilis. Part of the pathway for pentalenolactone biosynthesis. +"1.14.11.36","Requires iron(II) and ascorbate. Isolated from the bacteria Streptomyces exfoliatus, Streptomyces arenae and Streptomyces avermitilis. Part of the pentalenolactone biosynthesis pathway." +"1.14.13.166","Contains FAD. The enzyme catalyses the oxidation of 4-nitrocatechol with the concomitant removal of the nitro group as nitrite. Forms a two-component system with a flavoprotein reductase [1]. The enzymes from the bacteria Lysinibacillus sphaericus JS905 and Rhodococcus sp. strain PN1 were shown to also catalyse EC 1.14.13.29, 4-nitrophenol 2-monooxygenase [1,2] while the enzyme from Pseudomonas sp. WBC-3 was shown to also catalyse EC 1.14.13.167, 4-nitrophenol 4-monooxygenase [3]." +"1.14.13.167","Contains FAD. The enzyme catalyses the first step in a degradation pathway for 4-nitrophenol, the oxidation of 4-nitrophenol at position 4 with the concomitant removal of the nitro group as nitrite. The enzyme from the bacterium Pseudomonas sp. strain WBC-3 also catalyses EC 1.14.13.166, 4-nitrocatechol 4-monooxygenase." +"1.14.13.168","This plant enzyme, along with EC 2.6.1.99 L-tryptophan---pyruvate aminotransferase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan." +"1.14.13.169",The enzyme is involved in the biosynthesis of sphingolipids in yeast and plants. +"1.14.13.170",A FAD-dependent oxygenase. Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. The ketone undergoes a biological Baeyer-Villiger reaction. Part of the pathway of pentalenolactone biosynthesis. +"1.14.13.171",A FAD-dependent oxygenase. Isolated from the bacterium Streptomyces avermitilis. The ketone undergoes a biological Baeyer-Villiger reaction. +"1.14.15.11","A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis." +"1.14.99.47",Isolated from the plant Larrea tridentata (creosote bush). The enzyme has a strong preference for the 3' position of (+)-larreatricin. +"1.18.1.6","A flavoprotein (FAD). The enzyme, which transfers electrons from NADPH to adrenodoxin molecules, is the first component of the mitochondrial cytochrome P-450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones." +"1.21.3.7","A flavoprotein (FAD). The cofactor is covalently bound. Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta9-THCA with lower efficiency. Whereas the product was originally called Delta1-tetrahydrocannabinolate, the recommended name according to systematic peripheral numbering is Delta9-tetrahydrocannabinolate." +"1.21.3.8",Binds FAD covalently. Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also convert cannabinerolate to cannabidiolate with lower efficiency. +"2.1.1.260","This enzyme, which occurs in both prokaryotes and eukaryotes, recognizes specific pseudouridine residues (Psi) in small subunits of ribosomal RNA based on the local RNA structure. It recognizes Psi914 in 16S rRNA from the archaeon Methanocaldococcus jannaschii, Psi1191 in yeast 18S rRNA, and Psi1248 in human 18S rRNA." +"2.1.1.261",The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi. +"2.1.1.262",Two isoforms differing in their specificity were isolated from the green alga Botryococcus braunii BOT22. TMT-1 gave more of the dimethylated form whereas TMT2 gave more of the monomethylated form. +"2.1.1.263",Isolated from the green alga Botryococcus braunii BOT22. Shows a very weak activity with squalene. +"2.1.1.264","The enzyme specifically methylates guanine2069 at position N7 in 23S rRNA. In gamma-proteobacteria the enzyme also catalyses EC 2.1.1.173, 23S rRNA (guanine2445-N2)-methyltransferase, while in beta-proteobacteria the activities are carried out by separate proteins [1]. The enzyme from the gamma-proteobacterium Escherichia coli has RNA unwinding activity as well [1]." +"2.1.1.265",The enzyme is involved in the detoxification of tellurite. It can also methylate selenite and selenium dioxide. +"2.3.1.204","In the bacterium Bacillus subtilis it has been shown that the enzyme catalyses the +amidotransfer of the octanoyl moiety from [glycine cleavage system H]-N6-octanoyl-L-lysine (i.e. octanoyl-GcvH) to the E2 subunit (dihydrolipoamide acetyltransferase) of pyruvate dehydrogenase." +"2.3.1.205","The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family." +"2.3.1.206","A polyketide synthase catalysing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalysed by EC 4.4.1.26, olivetolic acid cyclase." +"2.3.1.207","This enzyme, which has been characterized from the bacterium Pseudomonas aeruginosa PAO1, catalyses the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via beta-oxidation, with malonyl-[acp], forming 3-oxodecanoyl-[acp], an intermediate of the fatty acid elongation cycle. The enzyme provides a shunt for beta-oxidation degradation intermediates into de novo fatty acid biosynthesis." +"2.3.1.208","The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177, biphenyl synthase) [1]." +"2.3.1.209","The non-activated product, 4-acetamido-4,6-dideoxy-alpha-D-glucose, is part of the O antigens of Shigella dysenteriae type 7 and Escherichia coli O7." +"2.3.1.210","The product, TDP-4-acetamido-4,6-dideoxy-D-galactose, is utilized in the biosynthesis of enterobacterial common antigen (ECA)." +"2.4.1.289","Requires Mn2+ or Mg2+. Isolated from Mycobacterium smegmatis [1] and Mycobacterium tuberculosis [2]. The enzyme catalyses the addition of a rhamnosyl unit to N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol, completing the synthesis of the linkage unit that attaches the arabinogalactan moiety to the peptidoglycan moiety in Mycobacterial cell wall." +"2.4.1.290",Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. +"2.4.1.291",Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. +"2.4.1.292",Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. +"2.4.1.293","Isolated from the bacterium Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. +" +"2.4.2.48","Archaeal tRNAs contain the modified nucleoside archaeosine at position 15. This archaeal enzyme catalyses the exchange of guanine at position 15 of tRNA with the base preQ0, which is ultimately modified to form the nucleoside archaeosine (cf. EC 2.6.1.97) [1]." +"2.4.99.18","Occurs in eukaryotes that form a glycoprotein by the transfer of a glucosyl-mannosyl-glucosamine polysaccharide to the side-chain of an L-asparagine residue in the sequence -Asn-Xaa-Ser- or -Asn-Xaa-Thr- (Xaa not Pro) in nascent polypeptide chains. The basic oligosaccharide is the tetradecasaccharide Glc3Man9GlcNAc2 (for diagram {polysacc/Dol14}). However, smaller oligosaccharides derived from it and oligosaccharides with additional monosaccharide units attached may be involved. See ref [2] for a review of N-glycoproteins in eukaryotes. Man3GlcNAc2 seems to be common for all of the oligosaccharides involved with the terminal N-acetylglucosamine linked to the protein L-asparagine. Occurs on the cytosolic face of the endoplasmic reticulum. The dolichol involved normally has 14-21 isoprenoid units with two trans double-bonds at the omega end, and the rest of the double-bonds in cis form." +"2.4.99.19","A bacterial enzyme that has been isolated from Campylobacter jejuni [1] and Campylobacter lari [2]. It forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chains. Requires Mn2+ or Mg2+. Occurs on the external face of the plasma membrane. The polyprenol involved is normally tritrans,heptacis-undecaprenol but a decaprenol is used by some species." +"2.5.1.99"," Requires Mn2+ for activity. The enzyme from the bacterium Pantoea agglomerans (previously known as Erwinia herbicola) produces the all-trans isomer of phytoene. cf. EC 2.5.1.32, 15-cis-phytoene synthase." +"2.5.1.100",Fumigaclavine C is an ergot alkaloid produced by some fungi of the Trichocomaceae family. Activity does not require any metal ions. +"2.5.1.101","Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative." +"2.5.1.102","Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate." +"2.5.1.103","Isolated from the green alga Botryococcus braunii BOT22. Unlike EC 2.5.1.21, squalene synthase, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme. This compound is then converted into either squalene (by EC 1.3.1.96, Botryococcus squalene synthase) or botryococcene (EC 1.3.1.97, botryococcene synthase). " +"2.6.1.96",Requires pyridoxal 5'-phosphate. The enzyme is found in plants that do not have the 2-oxoglutarate dependent enzyme (cf. EC 2.6.1.19). The reaction with pyruvate is reversible while the reaction with glyoxylate only takes place in the forward direction. +"2.6.1.97","In Euryarchaeota the reaction is catalysed by ArcS [1,2]. In Crenarchaeota, which do not have an ArcS homologue, the reaction is catalysed either by a homologue of EC 6.3.4.20, 7-cyano-7-deazaguanine synthase that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homologue of EC 1.7.1.13, preQ1 synthase [2]. The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors." +"2.6.1.98","A pyridoxal 5'-phosphate protein. This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the previous enzyme in the pathway, EC 1.1.1.335 (UDP-N-acetyl-2-amino-2-deoxyglucuronate oxidase)." +"2.6.1.99","This plant enzyme, along with EC 1.14.13.168, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan." +"2.7.4.27","The enzyme from the plants maize and Arabidopsis is bifunctional and also catalyses the phosphorylation of pyruvate, phosphate dikinase (EC 2.7.9.1), cf. EC 2.7.11.32, [pyruvate, phosphate dikinase] kinase [2-5]. " +"2.7.4.28","The enzyme from the bacterium Escherichia coli is bifunctional and catalyses both the phosphorylation and dephosphorylation of EC 2.7.9.2, pyruvate, water dikinase. cf. EC 2.7.11.33, [pyruvate, water dikinase] kinase [1]." +"2.7.7.82","Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella." +"2.7.7.83","The enzyme from plants and animals also has activity toward N-acetyl-alpha-D-glucosamine 1-phosphate (cf. EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase) [1,2]." +"2.7.8.36",Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. +"2.7.8.37",Isolated from the bacterium Escherichia coli. +"2.7.11.32","The enzymes from the plants Zea mays (maize) and Arabidopsis thaliana are bifunctional and catalyse both the phosphorylation and dephosphorylation of EC 2.7.9.1 (pyruvate, phosphate dikinase). cf. EC 2.7.4.27, [pyruvate, phosphate dikinase]-phosphate phosphotransferase [2-5]. The enzyme is specific for a reaction intermediate form of EC 2.7.9.1, and phosphorylates a threonine located adjacent to the catalytic histidine. The phosphorylation only takes place if the histidine is already phosphorylated [3-5]." +"2.7.11.33","The enzyme from the bacterium Escherichia coli is bifunctional and catalyses both the phosphorylation and dephosphorylation of EC 2.7.9.2, pyruvate, water dikinase. cf. EC 2.7.4.28, ([pyruvate, water dikinase] phosphate) phosphotransferase [1]. The enzyme is specific for a reaction intermediate form of EC 2.7.9.2, where it phosphorylates an active site histidine [1]. It has no activity toward EC 2.7.9.1 pyruvate, phosphate dikinase (cf. EC 2.7.11.32, [pyruvate, phosphate dikinase] kinase)." +"3.2.1.182",The enzyme from Triticum aestivum (wheat) has a higher affinity for DIMBOA glucoside than DIBOA glucoside. With Secale cereale (rye) the preference is reversed. +"3.2.1.183","The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus. It catalyses the first step of sialic acid (N-acetylneuraminic acid) biosynthesis. The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers [2]. The mammalian enzyme is bifunctional and also catalyses EC 2.7.1.60, N-acetylmannosamine kinase. +cf. EC 5.1.3.14, UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)." +"3.2.1.184","Requires Mg2+. Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates. The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose, which rapidly mutarotates to a mixture of anomers [1]. The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine [2]." +"3.5.1.111","The enzyme, which is highly specific for its substrate, participates in the nicotine degradation pathway of several Gram-positive bacteria." +"3.5.1.112","Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. The enzyme from the bacterium Streptomyces fradiae can also accept 2'''-acetyl-6'''-hydroxyneomycin C as substrate, cf. EC 3.5.1.113, 2'''-acetyl-6'''-hydroxyneomycin C deacetylase [2]." +"3.5.1.113","Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 3.5.1.112, 2'-N-acetylparomamine deacetylase." +"3.6.1.63",Isolated from the bacterium Escherichia coli. +"3.7.1.20","The enzyme is involved in bacterial degradation of 5-substituted salicylates, including gentisate (5-hydroxysalicylate), 5-nitrosalicylate and 5-halosalicylates." +"4.2.1.135","Contains NAD+ as a cofactor [2]. This is the first enzyme in the biosynthetic pathway of N,N'-diacetylbacillosamine [1], the first carbohydrate in the glycoprotein N-linked heptasaccharide in Campylobacter jejuni. This enzyme belongs to the short-chain dehydrogenase/reductase family of enzymes. " +"4.2.1.136","Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers. The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC 5.1.99.6), while the other catalyses the dehydration. Hence the enzyme can restore the complete mixture of isomers into NAD(P)H. The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC 4.2.1.93, ATP-dependent NAD(P)H-hydrate dehydratase)." +"4.2.1.137",The reaction occurs in the reverse direction. Isolated from Bacillus subtilis. Similar sesquarterpenoids are present in a number of Bacillus species. +"4.2.3.134","A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase)." +"4.2.3.135",Isolated from the fungus Armillaria gallica. Delta6-Protoilludene is the first step in the biosynthesis of the melleolides. +"4.2.3.136",Isolated from the roots of the plant Matricaria chamomilla var. recutita (chamomile). The enzyme also produced traces of five other sesquiterpenoids. +"4.2.3.137",Isolated from the plant Selaginella moellendorfii. The enzyme also gives two other sesquiterpenoids. +"4.2.3.138",Isolated from the plant Phyla dulcis (Aztec sweet herb). (+)-epi-alpha-Bisabolol is the precursor of the sweetener hernandulcin. +"4.2.3.139","Isolated from the plant Valeriana officinalis (valerian). Note that due to a different numbering system the product is also known as valerena-1,10-diene." +"4.2.3.140",Isolated from the plants Abies balsamea (balsam fir) [1] and Nicotiana tabacum (tobacco) [2]. +"4.3.1.28","Requires bound NAD+. The enzyme produces the non-proteinogenic amino acid L-pipecolate, which is incorporated into multiple secondary metabolite products, including rapamycin, tobulysin, virginiamycin and pristinamycin." +"4.3.3.7","The reaction can be divided into three consecutive steps: Schiff base formation with pyruvate, the addition of L-aspartate-semialdehyde, and finally transimination leading to cyclization with simultaneous dissociation of the product. The product of the enzyme was initially thought to be (S)-2,3-dihydrodipicolinate [1,2], and the enzyme was classified accordingly as EC 4.2.1.52, dihydrodipicolinate synthase. Later studies of the enzyme from the bacterium Escherichia coli have suggested that the actual product of the enzyme is (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate [3], and thus the enzyme has been reclassified as 4-hydroxy-tetrahydrodipicolinate synthase. However, the identity of the product is still controversial, as more recently it has been suggested that it may be (S)-2,3-dihydrodipicolinate after all [5]." +"4.4.1.26",Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. +"5.1.3.25",The equilibrium is strongly towards dTDP-beta-L-rhamnose. +"5.1.99.6","The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate. Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC 4.2.1.93, ATP-dependent NAD(P)H-hydrate dehydratase." +"5.2.1.14","The enzyme participates in a pathway leading to biosynthesis of strigolactones, plant hormones involved in promotion of symbiotic associations known as arbuscular mycorrhiza." +"5.4.99.58","The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases." +"1.1.1.344",The enzyme works equally well with NAD+ and NADP+. +"1.1.1.345","The enzymes, characterized from bacteria (Peptoclostridium difficile, Enterococcus faecalis and from lactic acid bacteria) prefer substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain. It also utilizes phenylpyruvate. The enzyme from the halophilic archaeon Haloferax mediterranei prefers substrates with a main chain of 3-4 carbons (pyruvate and 2-oxobutanoate). cf. EC 1.1.1.272, (D)-2-hydroxyacid dehydrogenase (NADP+). " +"1.1.1.346","The enzyme is involved in ketogluconate metabolism, and catalyses the reaction in vivo in the reverse direction to that shown [1]. It is used in the commercial microbial production of ascorbate. cf. EC 1.1.1.274, 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)." +"1.3.1.98",A flavoprotein (FAD). NADH can to a lesser extent replace NADPH. +"1.3.1.99","Isolated from the plants Catharanthus roseus, Olea europaea (common olive), and several Nepeta species. The enzyme reduces 8-oxogeranial, generating an unstable product that is subsequently cyclized into several possible products, either non-enzymically or by dedicated cyclases. The products, known as iridoids, are involved in the biosynthesis of many indole alkaloids. cf. EC 1.3.1.123, 7-epi-iridoid synthase." +"1.5.1.46","The enzyme participates in the biosynthesis of ergotamine, an ergot alkaloid produced by some fungi of the Clavicipitaceae family. The reaction is catalysed in the opposite direction to that shown. The substrate for the enzyme is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione." +"1.7.3.6","The enzyme from the heterotrophic nitrifying bacterium Paracoccus denitrificans contains three to five non-heme, non-iron-sulfur iron atoms and interacts with cytochrome c556 and pseudoazurin [2,3]. Under anaerobic conditions in vitro only nitrous oxide is formed [3]. Presumably nitroxyl is released and combines with a second nitroxyl to give nitrous oxide and water. When oxygen is present, nitrite is formed." +"1.11.1.22","The enzyme, characterized from the cyanobacterium Synechocystis PCC 6803, can reduce unsaturated fatty acid hydroperoxides and alkyl hydroperoxides. The enzyme, which utilizes NADPH generated by the photosynthetic electron transfer system, protects the cells from lipid peroxidation." +"1.12.1.5","A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+)." +"1.12.98.4","An iron-sulfur protein. The enzyme from the hyperthermophilic archaeon Pyrococcus furiosus is part of two heterotetrameric complexes where the beta and gamma subunits function as sulfur reductase and the alpha and delta subunits function as hydrogenases (EC 1.12.1.3, hydrogen dehydrogenase [NADP+] and EC 1.12.1.4, hydrogen dehydrogenase [NAD(P)+], respectively). Sulfur can also be used as substrate, but since it is insoluble in aqueous solution and polysulfide is generated abiotically by the reaction of hydrogen sulfide and sulfur, polysulfide is believed to be the true substrate [2]." +"1.13.12.20",Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. +"1.14.15.12","A heme-thiolate protein (P-450). The enzyme catalyses an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl-[acyl-carrier protein], an intermediate in the biosynthesis of biotin. The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal. The mechanism is similar to EC 1.14.15.6, cholesterol monooxygenase (side-chain-cleaving), followed by a hydroxylation step, which may occur spontaneously [2]." +"1.17.1.8","The substrate of the enzyme was initially thought to be (S)-2,3-dihydrodipicolinate [1], and the enzyme was classified accordingly as EC 1.3.1.26, dihydrodipicolinate reductase. Later studies of the enzyme from the bacterium Escherichia coli have suggested that the actual substrate of the enzyme is (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, and that its activity includes a dehydration step [2], and thus the enzyme has been reclassified as 4-hydroxy-tetrahydrodipicolinate reductase. However, the identity of the substrate is still controversial, as more recently it has been suggested that it may be (S)-2,3-dihydrodipicolinate after all [3]." +"1.23.1.1","The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that further reduces the product to the lignan (-)-secoisolariciresinol [EC 1.23.1.2, (+)-lariciresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6]. The 4-pro-R hydrogen of NADH is transferred to the 7-pro-R position of lariciresinol [1]." +"1.23.1.2","The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (+)-pinoresinol [EC 1.23.1.1, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6]." +"1.23.1.3","The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol [EC 1.23.1.4, (-)-lariciresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1], Linum perenne (perennial flax) [2] and Arabidopsis thaliana (thale cress) [3]." +"1.23.1.4","The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (-)-pinoresinol [EC 1.23.1.3, (-)-pinoresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1] and Linum corymbulosum [2]." +"2.1.1.266","The recombinant RlmJ protein is most active in methylating deproteinized 23S ribosomal subunit, and does not methylate the completely assembled 50S subunits [1]. " +"2.1.1.267","Isolated from Vitis vinifera (grape) [2]. Most active with delphinidin 3-glucoside but also acts on cyanidin 3-glucoside, cyanidin, myricetin, quercetin and quercetin 3-glucoside. The enzyme from Catharanthus roseus was most active with myricetin [1]." +"2.1.1.268",The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer. +"2.3.1.211","A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment." +"2.3.1.212",A polyketide synthase that catalyses the C6-C4 skeleton of phenylbutanoids in higher plants. +"2.3.1.213","Isolated from the plant Daucus carota (Afghan cultivar carrot). In addition to 1-O-(4-hydroxycinnamoyl)-beta-D-glucose, the enzyme can use the 1-O-sinapoyl- and 1-O-feruloyl- derivatives of beta-D-glucose. +" +"2.3.1.214",Isolated from the plant Salvia splendens (scarlet sage). +"2.3.1.215","Isolated from the plants Perilla frutescens and Gentiana triflora (clustered gentian). Acts on a range of anthocyanidin 3-O-glucosides, 3,5-di-O-glucosides and cyanidin 3-rutinoside. It did not act on delphinidin 3,3',7-tri-O-glucoside. Recombinant Perilla frutescens enzyme could utilize caffeoyl-CoA but not malonyl-CoA as alternative acyl donor." +"2.3.1.216",A polyketide synthase from the plant Aloe arborescens (aloe). +"2.3.1.217","A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well [2] (see EC 2.3.1.219, demethoxycurcumin synthase)." +"2.3.1.218","The enzyme has been characterized from the plant Curcuma longa (turmeric). It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA." +"2.3.1.219","A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well [1]." +"2.3.1.220","Involved in the biosynthesis of plant xanthones. The enzyme from the plant Hypericum androsaemum L can use 3-hydroxybenzoyl-CoA instead of benzoyl-CoA, but with lower activity (cf. EC 2.3.1.151, 2,3',4,6-tetrahydroxybenzophenone synthase)." +"2.3.1.221",A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase [1]. +"2.3.1.222","Part of the degradation pathway for propane-1,2-diol . " +"2.4.1.294",Isolated from the plant Daucus carota (Afghan cultivar carrot). +"2.4.1.295",Isolated from the plant Matthiola incana (stock). No activity with anthocyanidin 3-O-glucosides. +"2.4.1.296",Isolated from the plant Petunia hybrida. It does not act on an anthocyanidin 3-O-rutinoside +"2.4.1.297",Isolated from Ipomoea nil (Japanese morning glory). +"2.4.1.298","Isolated from the plants Perilla frutescens var. crispa, Verbena hybrida [1], Dahlia variabilis [2] and Gentiana triflora (clustered gentian) [3]. It will also act on anthocyanidin 3-O-(6-O-malonylglucoside) [2] and is much less active with hydroxycinnamoylglucose derivatives [3]. There is no activity in the absence of the 3-O-glucoside group." +"2.4.1.299","Isolated from the plant Dianthus caryophyllus (carnation). Also acts on other anthocyanidins and with other acyl-glucose donors. cf. EC 2.4.1.298, anthocyanidin 3-O-glucoside 5-O-glucosyltransferase." +"2.4.1.300",Isolated from the plant Delphinium grandiflorum (delphinium). Also acts on other anthocyanidins and with other acyl-glucose derivatives. +"2.4.2.49","Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. The enzyme requires a divalent metal ion, optimally Mg2+, Ni2+ or Co2+." +"2.4.2.50",Isolated from the plant Daucus carota (Afghan cultivar carrot). +"2.4.2.51","Isolated from the plants Matthiola incana (stock) [1] and Arabidopsis thaliana (mouse-eared cress) [2]. The enzyme has similar activity with the 3-glucosides of pelargonidin, cyanidin, delphinidin, quercetin and kaempferol as well as with cyanidin 3-O-rhamnosyl-(1->6)-glucoside and cyanidin 3-O-(6-acylglucoside). There is no activity with other UDP-sugars or with cyanidin 3,5-diglucoside." +"2.6.1.100","Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Also catalyses EC 2.6.1.101, L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase [2]." +"2.6.1.101","Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Also catalyses EC 2.6.1.100, L-glutamine:2-deoxy-scyllo-inosose aminotransferase." +"2.7.7.84","The enzyme is activated by binding to double-stranded RNA. The resulting product binds to and activates RNase L, which subsequently degrades the RNA. Oligoadenylates of chain lengths 2, 4 and 5 are also produced. The dimer does not have any known biological activity [2]." +"2.7.8.38",Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus. +"3.1.4.55","Binds Mn2+ and Zn2+. Isolated from the bacterium Escherichia coli, where it participates in the degradation of methylphosphonate." +"3.5.4.34",The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla [1]. tRNA editing is strictly dependent on Mg2+ [2]. +"3.5.4.35",The enzyme from Methanopyrus kandleri specifically catalyses the deamination of cytosine at position 8 of tRNA in 30 different tRNAs. This cytosine-to-uracil editing guarantees the proper folding and functionality of the tRNAs. +"3.5.4.36","The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site [3]. +" +"3.6.1.64","The human enzyme also hydrolyses GDP and dGDP, and to a lesser extent ITP, dITP and XTP." +"4.1.3.42","The enzyme from the bacterium Escherichia coli, which is specific for the (S)-enantiomer, is trifunctional, and also catalyses the reaction of EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase, and the beta-decarboxylation of oxaloacetate. cf. EC 4.1.3.16, 4-hydroxy-2-oxoglutarate aldolase." +"4.2.3.141","Isolated from the plant Salvia sclarea (clary sage). Originally thought to be synthesized in one step from geranylgeranyl diphosphate it is now known to require two enzymes, EC 4.2.1.133, copal-8-ol diphosphate synthase and EC 4.2.3.141, sclareol synthase. Sclareol is used in perfumery." +"4.2.3.142",Isolated from the plant Solanum habrochaites. 7-Epizingiberene is a whitefly repellant. +"4.3.99.4",The enzyme utilizes a glycine radical to break the C-N bond in choline. Found in choline-degrading anaerobic bacteria. +"4.7.1.1","This radical SAM (AdoMet) enzyme is part of the C-P lyase complex, which is responsible for processing phophonates into usable phosphate. Contains an [4Fe-4S] cluster. The enzyme from the bacterium Escherichia coli can act on additional alpha-D-ribose phosphonate substrates with different substituents attached to the phosphonate phosphorus (e.g. alpha-D-ribose-1-[N-(phosphonomethyl)glycine]-5-phosphate and alpha-D-ribose-1-(2-N-acetamidomethylphosphonate)-5-phosphate)." +"5.3.2.7","This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.1.111 (1,5-anhydro-D-fructose dehydratase) and EC 4.2.2.13 [exo-(1->4)-alpha-D-glucan lyase]. Ascopyrone P is an anti-oxidant [2]." +"5.3.2.8","This enzyme has been characterized from the bacterium Pseudomonas putida KT2440 and is involved in the degradation pathway of syringate and 3,4,5-trihydroxybenzoate. It catalyses the interconversion of two of the tautomers of 4-oxalomesaconate, a reaction that can also occur spontaneously." +"5.4.3.10","The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO). This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 5.4.3.11, phenylalanine aminomutase (D-beta-phenylalanine-forming)." +"5.4.3.11","The enzyme from the bacterium Pantoea agglomerans produces D-beta-phenylalanine, an intermediate in the biosynthesis of the polyketide non-ribosomal antibiotic andrimid. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 5.4.3.10, phenylalanine aminomutase (L-beta-phenylalanine-forming)." +"1.1.1.347",The enzyme from the bacterium Castellaniella defragrans is most active in vitro with perillyl alcohol [2]. The enzyme from the prune mite Carpoglyphus lactis also acts (more slowly) on farnesol but not on nerol [1]. +"1.1.1.348","This plant enzyme participates in the biosynthesis of the pterocarpan phytoalexins medicarpin, maackiain, and several forms of glyceollin. The enzyme has a strict stereo specificity for the 3R-isoflavanones." +"1.1.1.412","The enzyme, found in certain bacterial species, is part of a pathway for the production of olefins." +"1.1.1.349",Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. +"1.1.1.350","Involved in catabolism of purines. The enzyme from the bacterium Escherichia coli is specific for NAD+ [2]. cf. EC 1.1.1.154, ureidoglycolate dehydrogenase [NAD(P)+]." +"1.1.1.351","The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP+ and can accept both cofactors with similar efficiency. cf. EC 1.1.1.343, phosphogluconate dehydrogenase [NAD+-dependent, decarboxylating]." +"1.1.1.352","Isolated from the aflatoxin-producing mold Aspergillus parasiticus [2]. Involved in aflatoxin biosynthesis. 5'-Oxoaverantin will spontaneously form averufin by intramolecular ketalisation. cf. EC 4.2.1.142, 5'-oxoaverantin cyclase." +"1.1.1.353",Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis. +"1.2.99.8","The enzyme from the archaeon Sulfolobus acidocaldarius catalyses the oxidation of D-glyceraldehyde in the nonphosphorylative Entner-Doudoroff pathway. With 2,6-dichlorophenolindophenol as artificial electron acceptor, the enzyme shows a broad substrate range, but is most active with D-glyceraldehyde. It is not known which acceptor is utilized in vivo. The iron-sulfur protein contains FAD and molybdopterin guanine dinucleotide. " +"1.3.1.100","Contains FMN. The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The enzyme catalyses the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde. This hydrolyses spontaneously to form 6,8-dimethyl-6,7-didehydroergoline, which is converted to festuclavine by EC 1.5.1.44, festuclavine dehydrogenase." +"1.3.1.101","A flavoprotein (FAD). The enzyme from the archaeon Thermoplasma acidophilum is involved in the biosynthesis of membrane lipids. In vivo the reaction occurs in the reverse direction with the formation of 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate. cf. EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase." +"1.3.3.13","A flavoprotein from the bacterium Streptomyces noursei. The enzyme can also oxidize several other cyclo dipeptides, the best being cyclo(L-tryptophyl-L-tryptophyl) and cyclo(L-phenylalanyl-L-phenylalanyl) [1,2]." +"1.3.99.33",The enzyme from the bacterium Shewanella oneidensis MR-1 contains a noncovalently-bound FAD and a covalently-bound FMN. It functions as part of an anaerobic electron transfer chain that utilizes urocanate as the terminal electron acceptor. The activity has been demonstrated with the artificial donor reduced methyl viologen. +"1.3.99.34","A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol 1-phosphate with comparable activity. Geranylgeranyl diphosphate is partially reduced to phytyl diphosphate with 10% of the activity (cf. EC 1.3.1.83, geranylgeranyl diphosphate reductase). Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], the enzyme shows no activity with NADPH. In vitro the enzyme can utilize sodium dithionite as the electron donor." +"1.5.1.47","The enzyme, characterized from the bacterium Methylobacterium extorquens, is involved in biosynthesis of dephospho-tetrahydromethanopterin. The specific activity with NADH is 15% of that with NADPH at the same concentration [1]. It does not reduce 7,8-dihydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase)." +"1.7.1.15","An iron-sulfur flavoprotein (FAD) containing siroheme. This prokaryotic enzyme is specific for NADH. In addition to catalysing the 6-electron reduction of nitrite to ammonia, the enzyme from Escherichia coli can also catalyse the 2-electron reduction of hydroxylamine to ammonia. cf. EC 1.7.1.4, nitrite reductase [NAD(P)H]." +"1.13.11.74","The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent). The enzyme also has some activity with 2-amino-5-methylphenol and 2-amino-4-methylphenol [1]. The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.76, 2-amino-5-chlorophenol 1,6-dioxygenase [2]." +"1.14.11.37",Requires Fe2+ and ascorbate. Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of the aminoglycoside antibiotic kanamycin B to kanamycin A. +"1.14.13.172","This enzyme, which was characterized from the bacterium Ralstonia sp. U2, comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.7, ferredoxin---NAD(P)+ reductase), an iron-sulfur oxygenase, and ferredoxin." +"1.14.13.173",A heme-thiolate protein (cytochrome P-450). The enzyme is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin in the plant Glycyrrhiza uralensis (licorice). The enzyme from the plant Medicago truncatula can also hydroxylate beta-amyrin. +"1.14.13.174",A heme-thiolate (P-450) monooxygenase isolated from Aspergillus parasiticus. There is no reaction with (1'R)-averantin. Involved in aflatoxin biosynthesis. +"1.14.13.175",A heme-thiolate (P-450) enzyme. Isolated from the mold Aspergillus parasiticus. +"1.14.13.176","A heme-thiolate protein (P-450). Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen." +"1.14.15.13",A heme-thiolate (P-450) enzyme from the bacterium Bacillus subtilis. The order of events during the overall reaction is unknown. Pulcherrimic acid spontaneously forms an iron chelate with Fe(3+) to form the red pigment pulcherrimin [2]. +"1.14.19.8",A heme-thiolate protein (P-450). Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. +"1.14.21.9",A heme-thiolate (P-450) enzyme from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product. +"1.18.1.7","The enzyme from the aerobic bacterium Ralstonia sp. U2 donates electrons to both EC 1.14.12.12, naphthalene 1,2-dioxygenase and EC 1.14.13.172, salicylate 5-hydroxylase [1]. The enzyme from Pseudomonas NCIB 9816 is specific for the ferredoxin associated with naphthalene dioxygenase; it contains FAD and a [2Fe-2S] cluster." +"1.21.3.9","This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. The enzyme also possesses catalase activity, suggesting that the secondary product may be hydrogen peroxide rather than water. The nature of the secondary product has not been confirmed as of 2013." +"2.1.1.269","The enzyme from the marine bacteria Pelagibacter ubique and Ruegeria pomeroyi are specific towards S,S-dimethyl-beta-propiothetin. They do not demethylate glycine-betaine [1,2]." +"2.1.1.270","The protein from the plant Pisum sativum (garden pea) methylates (+)-6a-hydroxymaackiain at the 3-position. It also methylates 2,7,4'-trihydroxyisoflavanone on the 4'-position (cf. EC 2.1.1.212, 2,7,4-trihydroxyisoflavanone 4-O-methyltransferase) with lower activity." +"2.1.1.271","This enzyme, which participates in the anaerobic (early cobalt insertion) cobalamin biosynthesis pathway, catalyses the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A. See EC 2.1.1.133, precorrin-4 C11-methyltransferase, for the equivalent enzyme that participates in the aerobic cobalamin biosynthesis pathway." +"2.1.1.272","Isolated from the bacterium Bacillus megaterium. The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. Contains a [4Fe-4S] cluster. It can also convert cobalt-precorrin-3 to cobalt-precorrin-4. The reductant may be thioredoxin. See EC 2.1.1.131, precorrin-3B C17-methyltransferase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway." +"2.3.1.223",The enzyme acts in the opposite direction. The enzymes from the bacteria Escherichia coli and Pseudomonas sp. Y2 also have the activity of EC 2.3.1.174 (3-oxoadipyl-CoA thiolase). +"2.3.2.20","The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue [2]. The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L-phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl-L-tyrosyl) [1]." +"2.3.2.21","The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1]." +"2.3.2.22",The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue [2]. The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L-methionyl) [1]. +"2.4.2.52","ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (gamma-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase [4]." +"2.4.2.53",The enzyme shows no activity with UDP-4-amino-4-deoxy-beta-L-arabinose. +"2.4.2.54","The enzyme is involved in biosynthesis of tetrahydromethanopterin in archaea. It can utilize both 4-hydroxybenzoate and 4-aminobenzoate as substrates, but only the former is known to be produced by methanogenic archaea [4]. The activity is dependent on Mg2+ or Mn2+ [1]. " +"2.5.1.104","The enzyme is involved in the biosynthesis of spermidine from agmatine in some archaea and bacteria. The enzyme from the Gram-negative bacterium Thermus thermophilus accepts agmatine, spermidine and norspermidine with similar catalytic efficiency. The enzymes from the archaea Pyrococcus furiosus and Thermococcus kodakarensis prefer agmatine, but can utilize cadaverine, putrescine and propane-1,3-diamine with much lower catalytic efficiency. cf. EC 2.5.1.16, spermidine synthase, and EC 2.5.1.23, sym-norspermidine synthase. " +"2.5.1.105","The enzyme, which has been studied in the archaeon Methanocaldococcus jannaschii, is involved in the biosynthesis of tetrahydromethanopterin." +"2.5.1.106","The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2 [1], but also at C-3 [2]. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen. " +"2.5.1.107","Found in a number of fungi. Catalyses the last step in the biosynthetic pathway of the indole alkaloid fumitremorgin A. The enzyme from the fungus Neosartorya fischeri is also active with fumitremorgin B and 12alpha,13alpha-dihydroxyfumitremorgin C." +"2.7.1.178","The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with similar catalytic efficiency. cf. EC 2.7.1.45, 2-dehydro-3-deoxygluconokinase and EC 2.7.1.58, 2-dehydro-3-deoxygalactonokinase. " +"2.7.1.179",The enzyme from the bacterium Amycolatopsis mediterranei is specific for kanosamine. +"2.7.7.85","Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signalling molecule [1].The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity [2]." +"2.8.3.18","In some bacteria the enzyme catalyses the conversion of acetate to acetyl-CoA as part of a modified tricarboxylic acid (TCA) cycle [3,5,6]. In other organisms it converts acetyl-CoA to acetate during fermentation [1,2,4,7]. In some organisms the enzyme also catalyses the activity of EC 2.8.3.27, propanoyl-CoA:succinate CoA transferase." +"3.1.1.94",Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis. +"3.1.3.89","The enzyme, characterized from the bacterium Escherichia coli, shows strict specificity towards deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. A divalent metal cation is required for activity, with cobalt providing the highest activity." +"3.1.4.56","Contains one zinc atom and one iron atom per subunit of the dodecameric enzyme. It hydrolyses 7,8-dihydroneopterin 2',3'-cyclic phosphate, a step in tetrahydromethanopterin biosynthesis. In vitro the enzyme forms 7,8-dihydroneopterin 2'-phosphate and 7,8-dihydroneopterin 3'-phosphate at a ratio of 4:1." +"3.1.6.19","Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III sulfatase family. The enzyme from the bacterium Rhodococcus ruber prefers linear secondary-alkyl sulfate esters, particularly octan-2-yl, octan-3-yl, and octan-4-yl sulfates [1]. The enzyme from the bacterium Pseudomonas sp. DSM6611 utilizes a range of secondary-alkyl sulfate esters bearing aromatic, olefinic and acetylenic moieties. Hydrolysis proceeds through inversion of the configuration at the stereogenic carbon atom, resulting in perfect enantioselectivity. cf. EC 3.1.6.1, arylsulfatase (type I), and EC 1.14.11.77, alkyl sulfatase (type II)." +"3.2.1.185","The enzyme, which was identified in the bacterium Bifidobacterium longum JCM1217, removes the beta-L-arabinofuranose residue from the non-reducing end of multiple substrates, including beta-L-arabinofuranosyl-hydroxyproline (Ara-Hyp), Ara2-Hyp, Ara3-Hyp, and beta-L-arabinofuranosyl-(1->2)-1-O-methyl-beta-L-arabinofuranose.In the presence of 1-alkanols, the enzyme demonstrates transglycosylation activity, retaining the anomeric configuration of the arabinofuranose residue. cf. EC 3.2.1.55, non-reducing end alpha-L-arabinofuranosidase." +"3.3.2.12","The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 1.2.1.91, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway [1,3,4]. The enzyme from Escherichia coli also exhibits enoyl-CoA hydratase activity utilizing crotonyl-CoA as a substrate [2]." +"3.5.3.24","The enzyme, which has been characterized from the hyperthermophilic archaeon Pyrococcus kodakarensis and the thermophilic Gram-negative bacterium Thermus thermophilus, is involved in the biosynthesis of spermidine." +"3.5.4.37","This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4]. +" +"3.5.4.38","The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences. +" +"3.5.4.39","Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29)." +"3.6.1.65","The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-dCTP and 8-hydroxy-dGTP." +"4.1.2.51","The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase. " +"4.2.1.138","A multifunctional enzyme which also forms (+)-beta-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-beta-caryophyllene synthase]." +"4.2.1.139","The enzyme catalyses the formation of the additional ring in pterocarpan, the basic structure of phytoalexins produced by leguminous plants, including (-)-medicarpin, (+)-medicarpin, (-)-maackiain and (+)-maackiain. The enzyme requires that the hydroxyl group at C-4 of the substrate is in the (4R) configuration. The configuration of the hydrogen atom at C-3 determines whether the pterocarpan is the (+)- or (-)-enantiomer. The enzyme contains amino acid motifs characteristic of dirigent proteins." +"4.2.1.140","The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in Picrophilus torridus [3] and via the branched variant of the Entner-Doudoroff pathway in Sulfolobus solfataricus [1,2]. In vitro it utilizes D-gluconate with 6-10 fold higher catalytic efficiency than D-galactonate [1,3]. It requires Mg2+ for activity [1,2]. cf. EC 4.2.1.6, galactonate dehydratase, and EC 4.2.1.39, gluconate dehydratase. " +"4.2.1.141",The enzyme participates in pentose oxidation pathways that convert pentose sugars to the tricarboxylic acid cycle intermediate 2-oxoglutarate. +"4.2.1.142","Isolated from the aflatoxin-producing mold Aspergillus parasiticus. The enzyme also catalyses the conversion of versiconal to versicolorin B (EC 4.2.1.143, versicolorin B synthase). Involved in aflatoxin biosynthesis. " +"4.2.1.143",Isolated from the aflatoxin-producing mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis. +"4.2.1.144","A pyridoxal 5'-phosphate enzyme. The enzyme from the bacterium Amycolatopsis mediterranei participates in the pathway for rifamycin B biosynthesis. The enzyme also functions as a transaminase earlier in the pathway, producing UDP-alpha-D-kanosamine [3]. " +"4.2.3.143","Isolated from the root of the plant Thapsia garganica. The enzyme also produces germacrene D, bicyclogermacrene and traces of other sesquiterpenoids. See EC 4.2.3.77, (+)-germacrene D synthase and EC 4.2.3.100, bicyclogermacrene synthase. " +"4.2.99.22",Isolated from the plant Tulipa gesneriana (tulip). The reaction is an intramolecular transesterification producing the lactone. The enzyme also has a weak activity with 6-tuliposide B and 6-O-benzoyl-D-glucose. +"6.3.2.40",Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in several fungi species. The enzyme is a non-ribosomal peptide synthase. It is also active with O-methyl-L-tyrosine forming 4'-methoxycyclopeptine. +"6.3.4.21","The enzyme, which is involved in pyridine nucleotide recycling, can form beta-nicotinate D-ribonucleotide and diphosphate from nicotinate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) in the absence of ATP. However, when ATP is available the enzyme is phosphorylated resulting in a much lower Km for nicotinate. The phospho-enzyme is hydrolysed during the transferase reaction, regenerating the low affinity form. The presence of ATP shifts the products/substrates equilibrium from 0.67 to 1100 [4]." +"6.3.4.22","The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNAIle2 at the oxo group in position 2 of cytidine34. This modification is crucial for accurate decoding of the genetic code. In bacteria EC 6.3.4.19, tRNAIle-lysidine synthase, catalyses the modification of [tRNAIle2]-cytidine34 to [tRNAIle2]-lysidine34 . " +"1.1.1.354","The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor." +"1.1.1.355",Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A. +"1.1.1.356","The enzyme is involved in biosynthesis of L-colitose, a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyses the reaction in the reverse direction. The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar. The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H [1]. " +"1.1.1.357","The enzyme acts on multiple 3alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. This entry stands for enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known. [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) and EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)]." +"1.1.1.358","The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B5). This entry covers enzymes whose stereo specificity for NADP+ is not known. cf. EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific) and EC 1.1.1.214, 2-dehydropantolactone reductase (Si-specific)." +"1.1.1.359","The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway. " +"1.1.1.360","A zinc protein. The enzyme from the archaeon Picrophilus torridus is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. It shows 20-fold higher activity with NADP+ compared to NAD+. The oxidation of D-glucose and D-galactose is catalysed at a comparable rate (cf. EC 1.1.1.119, glucose 1-dehydrogenase (NADP+) and EC 1.1.1.120, galactose 1-dehydrogenase (NADP+))." +"1.1.5.9","A glycoprotein containing one mole of FAD per mole of enzyme. 2,6-Dichloroindophenol can act as acceptor. cf. EC 1.1.5.2, glucose 1-dehydrogenase (PQQ, quinone)." +"1.2.1.87","The enzyme forms a bifunctional complex with EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase, with a tight channel connecting the two subunits [1,2,3]. Also acts, more slowly, on glycolaldehyde and butanal. In Pseudomonas species the enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). NADP+ can replace NAD+ with a much slower rate [3]." +"1.2.1.88","This enzyme catalyses the irreversible oxidation of glutamate-gamma-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity [5]." +"1.3.1.102","Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde [3]. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones. Has very low activity with NAD as reductant (cf. EC 1.3.1.74, 2-alkenal reductase [NAD(P)+])." +"1.3.1.103",The enzyme acts in the degradation pathway of unsaturated organohalogen compounds by the bacterium Burkholderia sp. WS. +"1.6.1.3","A flavoprotein (FAD). The main function of the enzyme is to oxidize excess of NADPH, forming NADH that supplies electrons to the respiratory chain. cf. EC 7.1.1.1, proton-translocating NAD(P)+ transhydrogenase. This entry stands for enzymes whose stereo-specificity with respect to NADPH is not known. [cf. EC 1.6.1.1, NAD(P)+ transhydrogenase (Si-specific)]." +"1.8.1.18","This FAD-dependent enzyme, characterized from the archaeon Pyrococcus furiosus, is responsible for NAD(P)H-linked sulfur reduction. The activity with NADH is about half of that with NADPH. The reaction is dependent on CoA, although the nature of this dependency is not well understood." +"1.10.3.13","A copper-containing cytochrome. The enzyme from thermophilic archaea is part of the terminal oxidase and catalyses the reduction of O2 to water, accompanied by the extrusion of protons across the cytoplasmic membrane. " +"1.14.11.38","Requires Fe2+ and ascorbate. Found in the fungus Aspergillus fumigatus. Both atoms of a dioxygen molecule are incorporated into verruculogen [1,2]. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A. " +"1.14.11.39","Requires Fe2+. The enzyme is only able to hydroxylate free L-asparagine. It is not active toward D-asparagine. The beta-hydroxylated asparagine produced is incorporated at position 9 of the calcium-dependent antibiotic (CDA), an 11-residue non-ribosomally synthesized acidic lipopeptide lactone." +"1.14.11.40","Fe2+-dependent enzyme. The enzyme is involved in biosynthesis of the nonproteinogenic amino acid beta-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439. " +"1.14.11.41","Fe2+-dependent enzyme. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. It differs from EC 1.14.20.7, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming), because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine." +"1.14.13.177",A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of the indole alkaloid verruculogen. +"1.14.13.178","A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, methylxanthine N3-demethylase, and has a 5-fold higher activity with NADH than with NADPH [2]. Also demethylate 1-methylxantine with lower efficiency. Forms part of the degradation pathway of methylxanthines." +"1.14.13.179","A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.178, methylxanthine N1-demethylase, and has higher activity with NADH than with NADPH [1]. Also demethylates caffeine and theophylline with lower efficiency. Forms part of the degradation pathway of methylxanthines." +"1.14.20.3",Requires Fe2+. The enzyme is involved in the biosynthesis of the carbapenem beta-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. It catalyses a stereoinversion at C-5 and introduces a double bond between C-2 and C-3. +"1.14.21.10",A heme-thiolate protein (P-450). The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen. +"2.1.1.273","While the enzyme from the plant Zea mays is specific for benzoate [6], the enzymes from Arabidopsis species and Clarkia breweri also catalyse the reaction of EC 2.1.1.274, salicylate 1-O-methyltransferase [1,5]. In snapdragon (Antirrhinum majus) two isoforms are found, one specific for benzoate [2,3] and one that is also active towards salicylate [4]. The volatile product is an important scent compound in some flowering species [2]." +"2.1.1.274","The enzyme, which is found in flowering plants, also has the activity of EC 2.1.1.273, benzoate O-methyltransferase." +"2.1.1.275","The enzyme also methylates gibberellins A20 (95%), A3 (80%), A4 (69%) and A34 (46%) with significant activity." +"2.1.1.276","The enzyme also methylates gibberellins A34 (80%), A9 (60%), and A3 (45%) with significant activity." +"2.1.1.277","In the plant maize (Zea mays), the isoforms AAMT1 and AAMT2 are specific for anthranilate while AAMT3 also has the activity of EC 2.1.1.273, benzoate methyltransferase." +"2.1.1.278","Binds Mg2+. The enzyme is found in plants and is important for regulation of the plant hormone (indol-3-yl)acetate. The product, methyl (indol-3-yl)acetate is inactive as hormone [2]." +"2.1.1.279","The enzyme from anise (Pimpinella anisum) is highly specific for substrates in which the double bond in the propenyl side chain is located between C7 and C8, and, in contrast to EC 2.1.1.146, (iso)eugenol O-methyltransferase, does not have activity with eugenol or chavicol." +"2.1.1.280","The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine. The enzyme from broccoli (Brassica oleracea var. italica) also has the activity of EC 2.1.1.10, homocysteine S-methyltransferase [4]." +"2.1.1.281","The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin." +"2.1.1.282","The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs. These modifications are important for translational reading-frame maintenance. The enzyme is found in all eukaryotes and in some archaea, but not in bacteria. The eukaryotic enzyme is involved in the biosynthesis of wybutosine." +"2.1.1.283",The enzyme is involved in biosynthesis of the seco-anthraquinone (+)-geodin. +"2.1.1.284",The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. +"2.1.1.285",The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. +"2.1.1.286",In the yeast Saccharomyces cerevisiae this methylation is important for resistance towards hydrogen peroxide and the antibiotic anisomycin. +"2.1.1.287","The enzyme is found in eukaryotes. The adenine position refers to rRNA in the yeast Saccharomyces cerevisiae, in which the enzyme is important for ribosome biogenesis." +"2.1.3.12",The enzyme catalyses the last step in the biosynthesis of the aminocoumarin antibiotic novobiocin. The reaction is activated by ATP [1]. +"2.3.1.224","The enzyme is found in flowers like Clarkia breweri, where it is important for floral scent production. Unlike EC 2.3.1.84, alcohol O-acetyltransferase, this enzyme is active with alcohols that contain a benzyl ring." +"2.3.1.225","The enzyme catalyses the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association. " +"2.3.1.226",The enzyme is involved in the biosynthesis of the carbapenem beta-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. +"2.4.1.301",Involved in the biosynthetic pathway of kanamycins. The enzyme characterized from the bacterium Streptomyces kanamyceticus can also accept UDP-alpha-D-glucose with lower efficiency [2]. +"2.4.1.302","The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin. " +"2.4.1.303","The enzyme is involved in the the biosynthesis of the O-antigen repeating unit of Escherichia coli O7:K1 (VW187). Requires Mn2+. cf. EC 2.4.1.343, UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase." +"2.4.1.304","The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Shigella boydii B14. The activity is stimulated by Mn2+ or to a lesser extent by Mg2+, Ca2+, Ni2+ or Pb2+. " +"2.4.1.305",The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O56 and serotype O152. +"2.4.1.306",The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of Escherichia coli serotype O86. +"2.4.1.307",The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O86. +"2.4.1.308",The enzyme is involved in the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O86. +"2.4.1.309",The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O86. +"2.5.1.108","A [4Fe-4S] enzyme that modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. The enzyme is present in archae and eukaryotes but not in eubacteria. The enzyme is a member of the 'AdoMet radical' (radical SAM) family and generates the 3-amino-3-carboxypropyl radical by an uncanonical clevage of S-adenosyl-L-methionine. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii. Part of diphthamide biosynthesis." +"2.5.1.109","The enzyme from the fungus Aspergilus sp. MF297-2 is specific for brevianamide F [1], while the enzyme from Aspergillus versicolor accepts a broad range of trytophan-containing cyclic dipeptides [2]. Involved in the biosynthetic pathways of several indole alkaloids such as paraherquamides and malbrancheamides. " +"2.5.1.110",The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen. +"2.6.1.102",A pyridoxal 5'-phosphate enzyme. D-Perosamine is one of several dideoxy sugars found in the O-specific polysaccharide of the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. The enzyme catalyses the final step in GDP-alpha-D-perosamine synthesis. +"2.6.99.3","The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase." +"2.7.7.86",Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines. +"2.7.7.87","The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg [6]. " +"2.7.8.39","Requires Mg2+ or Mn2+ for activity. The enzyme is involved in biosynthesis of archaetidyl-myo-inositol, a compound essential for glycolipid biosynthesis in archaea. " +"2.7.8.40","The enzyme catalyses a step in the assembly of the repeating-unit of the O-antigen of the Gram-negative bacterium Aeromonas hydrophila AH-3. The enzyme shows no activity with UDP-N-acetyl-alpha-D-glucosamine (cf. EC 2.7.8.33, UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase). " +"3.1.3.90",The enzyme from the bacterium Enterococcus faecalis also has activity with the sucrose isomer turanose 6'-phosphate (alpha-D-glucopyranosyl-(1->3)-D-fructose 6-phosphate). +"3.5.3.25","The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species." +"3.6.3.54","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 3.6.3.4, Cu2+-exporting ATPase, which mainly transports the divalent copper ion." +"4.1.2.52","Requires Co2+ or Mn2+ for activity. The enzyme is also able to catalyse the aldol cleavage of 4-hydroxy-2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency. In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate. The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate [4]." +"4.1.2.53","Requires Mg2+ for activity. The enzyme can also use 2-oxo-3-deoxy-L-mannonate, 2-oxo-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) as substrates [2]." +"4.1.3.43","Requires Mn2+ for maximal activity [1,2]. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase [1,2,6]. The enzyme forms a bifunctional complex with EC 1.2.1.87, propanal dehydrogenase (CoA-propanoylating), with a tight channel connecting the two subunits [3,4,6]." +"4.1.99.20","Requires Mn2+ for maximum activity. The reaction is suggested to take place in several steps. Schiff base formation, double bond migration and dephosphorylation followed by ring opening and closing to form a pyrrolidine ring, and finally dehydration to form the product 3-amino-4-hydroxybenzoate. In the bacterium Streptomyces griseus the enzyme is involved in biosynthesis of grixazone, a yellow pigment that contains a phenoxazinone chromophore." +"5.1.1.19","The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species." +"5.4.2.12","The enzymes from higher plants, algae, some fungi, nematodes, sponges, coelenterates, myriapods, arachnids, echinoderms, archaea and some bacteria (particularly Gram-positive) have maximum activity in the absence of 2,3-bisphospho-D-glycerate. cf. EC 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent). The enzyme contains two Mn2+ (or in some species two Co2+ ions). The reaction involves a phosphotransferase reaction to serine followed by transfer back to the glycerate at the other position. Both metal ions are involved in the reaction." +"6.3.1.15",The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. +"6.3.3.5","The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species." +"6.3.4.23","This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase." +"5.5.1.22",Requires Mg2+. The enzyme from Tanacetum vulgare (tansy) can also use (3S)-linalyl diphosphate or more slowly neryl diphosphate in vitro. The reaction proceeds via isomeration of geranyl diphosphate to (3S)-linalyl diphosphate [3]. The oxygen and phosphorus originally linked to C-1 of geranyl diphosphate end up linked to C-2 of (-)-bornyl diphosphate [4]. cf. EC 5.5.1.8 (+)-bornyl diphosphate synthase. +"1.1.1.361","The enzyme, found in the bacterium Bacillus subtilis, is involved in a kanosamine biosynthesis pathway." +"1.1.1.362","The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin. " +"1.1.1.363","The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP+ while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD+. cf. EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+) and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+). " +"1.1.3.45","A flavoprotein (FAD). This bifunctional enzyme is a secreted flavin-dependent enzyme that is involved in the modification of the terminal sugar residues in the biosynthesis of aclacinomycins. The enzyme utilizes the same active site to catalyse the oxidation of the rhodinose moiety of aclacinomycin N to the cinerulose A moiety of aclacinomycin A and the oxidation of the latter to the L-aculose moiety of aclacinomycin Y (cf. EC 1.3.3.14, aclacinomycin A oxidase). " +"1.2.7.11","Contains thiamine diphosphate and [4Fe-4S] clusters [2]. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For example, see EC 1.2.7.3, 2-oxoglutarate synthase and EC 1.2.7.7, 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)." +"1.3.1.104","The enzyme completes each cycle of fatty acid elongation by catalysing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl-carrier protein, in an NADPH-dependent manner. This entry stands for enzymes whose stereo-specificity with respect to NADP+ is not known. [cf. EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific), EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.3.1.9, enoyl-[acyl-carrier-protein] reductase (NADH)]." +"1.3.3.14",A flavoprotein (FAD). This bifunctional enzyme is a secreted flavin-dependent enzyme that is involved in the modification of the terminal sugar residues in the biosynthesis of aclacinomycins. The enzyme utilizes the same active site to catalyse the oxidation of the rhodinose moiety of aclacinomycin N to the cinerulose A moiety of aclacinomycin A (cf. EC 1.1.3.45) and the oxidation of the latter to the L-aculose moiety of aclacinomycin Y. +"1.5.5.2","A flavoprotein (FAD). The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor [3]. In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88, L-glutamate gamma-semialdehyde dehydrogenase. Both activities are carried out by the same enzyme in enterobacteria." +"1.6.3.2","A flavoprotein (FAD). NADPH is a better substrate than NADH [1,3]. By removal of oxygen the enzyme is involved in aerobic tolerance in the thermophilic anaerobic archaeon Thermococcus profundus and in Giardia intestinalis, a microaerophilic single-celled parasite of the order Diplomonadida. " +"1.6.3.3","A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O2-forming enzyme and a H2O-forming enzyme (cf. EC 1.6.3.4, NADH oxidase (H2O-forming)) [1]. The enzymes from the anaerobic archaea Methanocaldococcus jannaschii [6] and Pyrococcus furiosus [3] also produce low amounts of H2O. Unlike EC 1.6.3.1 (NAD(P)H oxidase) it has no activity towards NADPH. " +"1.6.3.4","A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O-forming enzyme and a H2O2-forming enzyme (cf. EC 1.6.3.3, NADH oxidase (H2O2-forming)) [1]." +"1.8.1.19",A iron-sulfur flavoprotein. In the archaeon Pyrococcus furiosus the enzyme is involved in the oxidation of NADPH which is produced in peptide degradation. The enzyme also catalyses the reduction of sulfur with lower activity. +"1.13.11.76","The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent). The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.74, 2-aminophenol 1,6-dioxygenase." +"1.13.12.21",The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens. +"1.14.11.42",Requires Fe2+. The enzyme is not active with wybutosine. +"1.14.11.43","Fe2+-dependent enzyme. The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (S)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop [1,2]. " +"1.14.11.44","Fe2+-dependent enzyme. The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop [1,2]." +"1.14.13.180","The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The enzyme from Streptomyces purpurascens is an FAD monooxygenase. " +"1.14.13.181","The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogues (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position. " +"1.14.13.182","The enzyme from the bacterium Pseudomonas aeruginosa catalyses the terminal step in biosynthesis of the signal molecule 2-heptyl-3,4-dihydroxyquinoline that plays a role in regulation of virulence genes. " +"1.14.14.14","A cytochrome P-450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase." +"1.14.99.48","This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin. The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % delta-staphylobilin, respectively." +"2.1.1.288",The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin. +"2.1.3.13","The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate, and the subsequent carbamoylation of kanamycin and tobramycin. cf. EC 2.1.3.14, tobramycin carbamoyltransferase." +"2.1.3.14","Binds iron. The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate (see EC 2.1.3.13, ATP carbamoyltransferase), and the subsequent carbamoylation of kanamycin and tobramycin." +"2.3.1.227",D-Perosamine is one of several dideoxy sugars found in the O-antigen component of the outer membrane lipopolysaccharides of Gram-negative bacteria. +"2.3.1.228","The enzyme, found in the bacterium Bradyrhizobium japonicum, does not accept isovaleryl-[acyl-carrier protein] as acyl donor (cf. EC 2.3.1.184, acyl-homoserine-lactone synthase)." +"2.3.1.229","The enzyme is found in the bacterium Rhodopseudomonas palustris, which produces N-(4-coumaroyl)-L-homoserine lactone as a quorum-sensing signal." +"2.5.1.111",The enzyme's product feeds into the biosynthesis of the aminocoumarin antibiotics clorobiocin and novobiocin [1]. +"3.1.1.95",The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species. +"3.1.3.91","The enzyme also has low activity with N7-methyl-GDP, producing N7-methyl-GMP. Does not accept AMP or GMP, and has low activity with UMP." +"3.1.3.92","The enzyme, found in the bacterium Bacillus subtilis, is involved in a kanosamine biosynthesis pathway." +"3.2.1.186","The enzyme has been characterized from the plants Cheilocostus speciosus and Solanum torvum. It also hydrolyses the 26-beta-D-glucose group from related steroid glucosides such as protogracillin, torvoside A and torvoside H." +"3.6.3.55","An ABC-type (ATP-binding cassette-type) ATPase. The enzymes from the archaeon Pyrococcus furiosus, the Gram-positive bacterium Eubacterium acidaminophilum and the Gram-negative bacterium Campylobacter jejuni transport tungsten into the cell for incorporation into tungsten-dependent enzymes. " +"4.1.2.54",The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). +"4.1.3.44","This enzyme, which is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters [3,4]. Carbons C2 and C3 from pyruvate are incorporated into 4-demethylwyosine [3]. The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine." +"4.2.1.145",A pyridoxal 5'-phosphate protein. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. +"4.2.1.146",The enzyme takes part in a D-galacturonate degradation pathway in the fungi Trichoderma reesei (Hypocrea jecorina) and Aspergillus niger. +"4.2.3.144","The enzyme is a component of the herbivore-induced indirect defense system. The product, (E,E)-geranyllinalool, is a precursor to the volatile compound 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT), which is released by many plants in response to damage." +"4.4.1.27","The enzyme contains Zn2+. The hyperthermophilic archaeon Acidianus sp. A1-3 obtains energy by the conversion of carbon disulfide to hydrogen sulfide, with carbonyl sulfide as an intermediate. " +"5.1.3.26",The enzyme is involved in biosynthesis of the repeating tetrasaccharide unit of the O-antigen produced by some Gram-negative bacteria. +"5.3.1.29",This archaeal enzyme is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The enzyme is activated by cAMP [2]. +"5.4.99.59",The enzyme is involved in the biosynthesis of the Escherichia coli O52 O antigen. +"5.5.1.23","The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin." +"6.3.1.16",The enzyme is involved in the biosynthesis of the carbapenem beta-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. +"6.3.3.6",The enzyme is involved in the biosynthesis of the carbapenem beta-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum. +"6.5.1.5","The enzyme, which is specific for GTP, was characterized from the archaeon Pyrococcus furiosus. The enzyme converts the 3'-terminal phosphate of various RNA substrates into the 2',3'-cyclic phosphodiester in a GTP-dependent reaction. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by GTP, forming a phosphoramide bond between guanylate and a histidine residue. The guanylate group is then transferred to the 3'-phosphate terminus of the substrate, forming the capped structure [RNA]-3'-(5'-diphosphoguanosine). Finally, the enzyme catalyses an attack of the vicinal O-2' on the 3'-phosphorus, which results in formation of cyclic phosphate and release of the guanylate. cf. EC 6.5.1.4, RNA 3'-terminal-phosphate cyclase (ATP)." +"1.1.1.364","The enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II." +"1.1.1.365","The enzyme from plants is involved in ascorbic acid (vitamin C) biosynthesis [1,2]. The enzyme from the fungus Trichoderma reesei (Hypocrea jecorina) is involved in a eukaryotic degradation pathway of D-galacturonate. It is also active with D-glucuronate and glyceraldehyde [3]. Neither enzyme shows any activity with NADH." +"1.1.1.366","Involved in the catabolism of ascorbate (vitamin C) to tartrate. No activity is observed with NADP+ (cf. EC 1.1.1.264, L-idonate 5-dehydrogenase)." +"1.1.98.4",An enzyme complex that contains FAD and iron-sulfur clusters. The enzyme has been described in the archaea Methanosarcina mazei and Archaeoglobus fulgidus. +"1.1.98.5",The enzyme isolated from the methanogenic archaea Methanogenium liminatans catalyses the reversible oxidation of various secondary and cyclic alcohols to the corresponding ketones. +"1.1.99.39","Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+." +"1.3.1.105","The enzyme was dicovered in strawberry (Fragaria x ananassa), where it produces furaneol, one of the major aroma compounds in the fruits. It has also been detected in tomato (Solanum lycopersicum) and pineapple (Ananas comosus). The enzyme can also act on derivatives substituted at the methylene functional group. The enzyme from the yeast Saccharomyces cerevisiae acts on (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one and produces homofuraneol, an important aroma compound in soy sauce and miso. NADPH is the preferred cofactor." +"1.3.8.11","Contains FAD. The enzyme, characterized from the strict anaerobic bacterium Syntrophus aciditrophicus, is involved in production of cyclohexane-1-carboxylate, a byproduct produced by that organism during fermentation of benzoate and crotonate to acetate." +"1.5.3.22",The enzyme contains FMN and a binuclear iron center. The enzyme from the archaeon Methanothermobacter marburgensis is Si-face specific with respect to C-5 of coenzyme F420 [2]. +"1.5.7.2",The enzyme from the archaeon Methanosarcina mazei contains iron-sulfur centres and FAD. +"1.13.11.77","Binds Fe2+. The enzyme isolated from the bacterium Pseudomonas sp. 42A2 has similar activity with all the three Delta9 fatty acids. cf. EC 1.13.11.62, linoleate 10R-lipoxygenase." +"1.14.13.183",A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from ginseng (Panax ginseng). +"1.14.13.184",A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from the rhizomes of ginseng (Panax ginseng). +"2.1.1.289","This enzyme catalyses the methylation at C-5 of cobalt-precorrin-7, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway. The equivalent activity in the aerobic adenosylcobalamin biosynthesis pathway is catalysed by the bifunctional enzyme EC 2.1.1.132, precorrin-6B C5,15-methyltransferase (decarboxylating)." +"2.1.1.290","The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.3.1.231, tRNAPhe 7-[(3S)-4-methoxy-(3-amino-3-carboxypropyl)wyosine37-O]-carbonyltransferase [2]." +"2.1.1.291",The enzyme from the plant Papaver somniferum (opium poppy) methylates (S)- and (R)-reticuline with equal efficiency and is involved in the biosynthesis of tetrahydrobenzylisoquinoline alkaloids. +"2.1.1.292","The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. In vitro the enzyme from Streptomyces sp. C5 also catalyses the 4-O-methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy-13-deoxycarminomycin [3]. " +"2.1.1.293","Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen." +"2.3.1.230","The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex. The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue. Together with the PqsB subunit, the proteins catalyse the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring." +"2.3.1.231","The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-[2-hydroxy-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.1.1.290, tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase [2]." +"2.4.1.310",The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin. +"2.4.1.311",The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin. +"2.4.1.312","The human protein is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains." +"2.4.1.313","The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor [1]. The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains." +"2.4.1.314",The glucosyl group forms a 1->6 bond to the glucosyloxy moiety at C-20 of ginsenoside Rd. Isolated from sanchi ginseng (Panax notoginseng). +"2.4.2.55","The enzyme is involved in the biosynthesis of phenolic cobamides in the Gram-positive bacterium Sporomusa ovata. It can also transfer the phospho-D-ribosyl group to 4-methylphenol and 5,6-dimethylbenzimidazole. The related EC 2.4.2.21, nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase, also transfers the phospho-D-ribosyl group from nicotinate D-ribonucleotide to 5,6-dimethylbenzimidazole, but shows no activity with 4-methylphenol or phenol. " +"2.4.2.56","The enzyme from the plant Euonymus alatus also catalyses the 3-O-D-xylosylation of other flavonols (e.g. quercetin, isorhamnetin, rhamnetin, myricetin, fisetin) with lower activity. " +"2.5.1.112","Involved in the biosynthesis of cytokinins in plants. The IPT4 isoform from the plant Arabidopsis thaliana is specific for ADP and ATP [1]. Other isoforms, such as IPT1 from Arabidopsis thaliana [1,2] and the enzyme from the common hop, Humulus lupulus [3], also have a lower activity with AMP (cf. EC 2.5.1.27, adenylate dimethylallyltransferase)." +"2.5.1.113","A pyridoxal-phosphate protein. The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor. The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O3-acetyl-L-serine (cf. EC 2.5.1.65, O-phosphoserine sulfhydrylase)." +"2.5.1.114","The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases. This modification is essential for translational reading-frame maintenance. The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNAPhe." +"2.6.1.103","A pyridoxal-5'-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin." +"2.8.3.19","The enzymes characterized from the bacteria Escherichia coli and Acetobacter aceti can also use formyl-CoA and oxalate (EC 2.8.3.16, formyl-CoA transferase) or formyl-CoA and acetate, with significantly reduced specific activities." +"2.7.1.180","The enzyme catalyses the transfer of the FMN portion of FAD and its covalent binding to the hydroxyl group of an L-threonine residue in a target flavin-binding protein such as the B and C subunits of EC 7.2.1.1, NADH:ubiquinone reductase (Na+-transporting). Requires Mg2+." +"2.7.1.223","The enzyme, characterized from the bacterium Salmonella enterica, can phosphorylate exogeneously-provided 5-amino-1-(beta-D-ribosyl)imidazole to form 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole (AIR), an important intermediate in the production of both purine mononucleotides and the hydroxymethyl pyrimidine moiety of thiamine." +"3.2.1.187","The enzyme, which was identified in the bacterium Bifidobacterium longum JCM1217, is specific for (Ara-f)3-Hyp, a sugar chain found in hydroxyproline-rich glyoproteins such as extensin and lectin. The enzyme was not able to accept (Ara-f)2-Hyp or (Ara-f)4-Hyp as substrates. In the presence of 1-alkanols, the enzyme demonstrates transglycosylation activity, retaining the anomeric configuration of the arabinofuranose residue." +"3.2.1.188",Isolated from oat (Avena sativa) seedlings. The product acts as a defense system against fungal infection. Also acts on avenacoside A. +"3.2.1.189","The enzyme is involved in degradation of the steroid saponin dioscin by some fungi of the Absidia genus. The enzyme can also hydrolyse 3-O-[alpha-L-Ara-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin into diosgenin and free sugars as the final products. cf. EC 3.2.1.190, dioscin glycosidase (3-O-beta-D-Glc-diosgenin-forming). " +"3.2.1.190","The enzyme is involved in the hydrolysis of the steroid saponin dioscin by the digestive system of Sus scrofa (pig). cf. EC 3.2.1.189, dioscin glycosidase (diosgenin-forming). " +"3.3.2.13",The enzyme found in several bacterial species is involved in the biosynthesis of macrocyclic polyketides. +"3.4.21.121","The enzyme is a serine peptidase, which has been shown to cleave prothrombin and prekallikrein. It hydrolyses the complement component C5 releasing complement component C5a." +"3.5.1.114","This enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). It preferentially deacetylates Nalpha-acetylated aromatic amino acids and mercapturic acids (S-conjugates of N-acetyl-L-cysteine) that are usually not deacetylated by EC 3.5.1.14, N-acyl-aliphatic-L-amino acid amidohydrolase. The enzyme is significantly activated by Co2+ and Ni2+ [3]. Some bacterial aminoacylases demonstrate substrate specificity for both EC 3.5.1.14 and EC 3.5.1.114. cf. EC 3.5.1.14, N-acyl-aliphatic-L-amino acid amidohydrolase and EC 3.5.1.15, aspartoacylase." +"3.5.1.115","The enzyme that is found in actinomycetes is involved in the detoxification of oxidizing agents and electrophilic antibiotics. The enzyme has low activity with 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol as substrate (cf. EC 3.5.1.103, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase) [2]." +"3.5.3.26","Binds Mn2+. This enzyme, found in plants and bacteria, is part of the ureide pathway, which enables the recycling of the nitrogen in purine compounds. In plants it is localized in the endoplasmic reticulum." +"3.6.1.66","The enzymes from the bacterium Escherichia coli and the archaea Methanococcus jannaschii and Archaeoglobus fulgidus are highly specific for XTP, dITP and ITP. The activity is dependent on divalent cations, Mg2+ is preferred." +"4.1.3.45","The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3]." +"5.1.3.27","The enzyme is involved in the biosynthetic pathway of dTDP-6-deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II. " +"4.3.1.29","The enzyme, from the bacterium Salmonella typhimurium, is involved in the degradation pathway of 2-amino-2-deoxy-D-gluconate." +"5.5.1.24",The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols). +"1.1.1.367",Part of the biosynthesis of UDP-N-acetyl-L-fucosamine. Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. +"1.1.1.368",The enzyme participates in the central benzoyl-CoA degradation pathway of some anaerobic bacteria such as Thauera aromatica. +"1.1.1.369","The enzyme, found in the bacterium Bacillus subtilis, also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. It shows trace activity with D-ribose and D-fructose [1]. It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA." +"1.1.1.370","The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC 1.1.1.371, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA." +"1.1.1.371","The enzyme, found in the bacterium Bacillus subtilis, has no activity with NAD+ [cf. EC 1.1.1.370, scyllo-inositol 2-dehydrogenase (NAD+)]." +"1.1.5.10","The enzyme from mammalian kidney contains one mole of FAD per mole of enzyme.(R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors. " +"1.2.1.89","The enzyme from the archaea Thermoplasma acidophilum and Picrophilus torridus is involved in the non-phosphorylative Entner-Doudoroff pathway. cf. EC 1.2.99.8, glyceraldehyde dehydrogenase (FAD-containing)." +"1.3.1.106","The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of cobalt-precorrin-6A. The enzyme from the bacterium Bacillus megaterium has no activity with NADPH. See EC 1.3.1.54, precorrin-6A reductase, for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway." +"1.3.98.2","The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)], EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)], and EC 1.3.5.4 [fumarate reductase (quinol)]." +"1.3.99.35","The enzyme, together with EC 1.1.1.396, bacteriochlorophyllide a dehydrogenase, and EC 4.2.1.165, chlorophyllide a hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. This enzyme catalyses trans-reduction of the B-ring; the product has the (7R,8R)-configuration. The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of nitrogenase (EC 1.18.6.1), which catalyses an ATP-driven reduction. " +"1.5.98.1","Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus." +"1.5.98.2",Catalyses an intermediate step in methanogenesis from CO2 and H2 in methanogenic archaea. +"1.6.3.5","Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta-NAD(P)+. These isomeric forms, generated by nonspecific reduction of beta-NAD(P)+ or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration." +"1.10.3.14","This terminal oxidase enzyme is unable to pump protons but generates a proton motive force by transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water. The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) is 1. The bd-I oxidase from the bacterium Escherichia coli is the predominant respiratory oxygen reductase that functions under microaerophilic conditions in that organism. cf. EC 1.10.3.10, ubiquinol oxidase (H+-transporting)." +"1.14.13.185",A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin. +"1.14.13.186","A cytochrome P-450 heme-thiolate enzyme. Involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria." +"1.14.13.187","Requires FAD. Isolated from the bacterium Micromonospora carbonacea var. africana. The nitroso group is probably spontaneously oxidized to a nitro group giving dTDP-beta-L-evernitrose, which is involved in the biosynthesis of the antibiotic everninomycin. The reaction was studied using dTDP-beta-L-4-epi-vancosamine (dTDP-4-O-desmethyl-beta-L-evernitrosamine)." +"1.14.13.188",A heme-thiolate protein (P-450). Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin. +"1.16.1.10","A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH)." +"1.21.99.2","This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis." +"2.1.1.294","The enzyme is involved in the biosynthesis of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a. O-Polysaccharide structures vary extensively because of differences in the number and type of sugars in the repeat unit. The dual kinase/methylase WbdD also catalyses the preceding phosphorylation of alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.7.1.181, polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase)." +"2.1.1.295","Involved in the biosynthesis of plastoquinol, as well as vitamin E (tocopherols and tocotrienols)." +"2.1.1.296","The enzyme, found in higher eukaryotes including insects and vertebrates, and their viruses, methylates the ribose of the ribonucleotide at the second transcribed position of mRNAs and snRNAs. This methylation event is known as cap2. The human enzyme can also methylate mRNA molecules where the upstream ribonucleotide is not methylated (see EC 2.1.1.57, methyltransferase cap1), but with lower efficiency [2]." +"2.1.1.297","Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity." +"2.1.1.298",Modifies the glutamine residue in the glycylglycylglutamine (GGQ) motif of ribosomal protein uL3 (Gln150 in the protein from the bacterium Escherichia coli). The enzyme does not act on peptide chain release factor 1 or 2. +"2.1.1.299","This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal." +"2.1.1.300","The enzyme, isolated from the plant Thalictrum flavum, also methylates (R,S)-stylopine and (S)-scoulerine (11%) with lower activity (14% and 11%, respectively)." +"2.3.1.232","The enzyme from Concord grape (Vitis labrusca) is solely responsible for the production of O-methyl anthranilate, an important aroma and flavor compound in the grape. The enzyme has a broad substrate specificity, and can use a range of alcohols with substantial activity, the best being butanol, benzyl alcohol, iso-pentanol, octanol and 2-propanol. It can use benzoyl-CoA and acetyl-CoA as acyl donors with lower efficiency. In addition to O-methyl anthranilate, the enzyme might be responsible for the production of ethyl butanoate, methyl-3-hydroxy butanoate and ethyl-3-hydroxy butanoate, which are present in large quantities in the grapes. Also catalyses EC 2.3.1.196, benzyl alcohol O-benzoyltransferase." +"2.4.1.315","The enzyme is found in several bacterial species. The enzyme from Bacillus subtilis is specific for glucose [1]. The enzyme from Mycoplasma genitalium can incoporate galactose with similar efficiency, but forms mainly 1,2-diacyl-diglucopyranosyl-sn-glycerol in vivo [3]. The enzyme from Staphylococcus aureus can also form glucosyl-glycero-3-phospho-(1'-sn-glycerol) [2]." +"2.4.1.316","The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene." +"2.4.1.317","The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. " +"2.4.1.318","The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. " +"2.4.1.319","The enzyme, isolated from the ruminal bacterium Ruminococcus albus, catalyses the reversible phosphorolysis of beta-1,4-mannooligosaccharide with a minimum size of three monomers." +"2.4.1.320",The enzyme isolated from the anaerobic bacterium Bacteroides thetaiotaomicron is involved in the degradation of host-derived N-glycans. +"2.4.1.321",The enzyme occurs in cellulolytic bacteria and fungi. It catalyses the reversible phosphorolysis of cellobionic acid. In the synthetic direction it produces 4-O-beta-D-glucopyranosyl-D-glucuronate from alpha-D-glucose 1-phosphate and D-glucuronate with low activity. +"2.4.1.322","The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin. " +"2.4.1.323",Isolated from the plant Catharanthus roseus (Madagascar periwinkle). Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetin. cf. EC 2.4.1.324 7-deoxyloganetin glucosyltransferase. +"2.4.1.324",Isolated from the plants Catharanthus roseus (Madagascar periwinkle) and Gardenia jasminoides (cape jasmine). With Gardenia it also acts on genipin. Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetate. cf. EC 2.4.1.323 7-deoxyloganetic acid glucosyltransferase. +"2.4.2.57",The enzyme from archaea is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The activity with CMP and UMP requires activation by cAMP [2]. +"2.4.99.20","This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase." +"2.5.1.115","Requires Mg2+ for activity [3]. Involved in the biosynthesis of the vitamin E tocopherols. While the enzyme from the cyanobacterium Synechocystis PCC 6803 has an appreciable activity with geranylgeranyl diphosphate (EC 2.5.1.116, homogentisate geranylgeranyltransferase), the enzyme from the plant Arabidopsis thaliana has only a low activity with that substrate [1,3,4]." +"2.5.1.116","Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2]." +"2.5.1.117","Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10 to C20 prenyl diphosphates, producing main products that are not decarboxylated [2]." +"2.5.1.118","The enzyme from the plants Lathyrus odoratus (sweet pea) and L. sativus (grass pea) also forms 3-(5-oxoisoxazolin-4-yl)-L-alanine in vitro (cf. EC 2.5.1.119). However, only 3-(5-oxoisoxazolin-2-yl)-L-alanine is formed in vivo. 3-(5-oxoisoxazolin-2-yl)-L-alanine is the biosynthetic precursor of the neurotoxin N3-oxalyl-L-2,3-diaminopropanoic acid, the cause of lathyrism. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, beta-pyrazolylalanine synthase." +"2.5.1.119","3-(5-Oxoisoxazolin-4-yl)-L-alanine is an antifungal antibiotic produced by the bacterium Streptomyces platensis. The enzymes from the plants Lathyrus odoratus (sweet pea), L. sativus (grass pea) and Citrullus vulgaris (watermelon) that catalyse EC 2.5.1.118 (beta-(isoxazolin-5-on-2-yl)-L-alanine synthase) also catalyse this reaction in vitro, but not in vivo. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, beta-pyrazolylalanine synthase." +"2.5.1.120","This enzyme is a member of the 'AdoMet radical' (radical SAM) family. S-Adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis." +"2.6.1.104","A pyridoxal-phosphate protein. The enzyme, found in the bacterium Bacillus subtilis, is involved in a kanosamine biosynthesis pathway." +"2.6.1.105","A pyridoxal 5'-phosphate enzyme [2]. Participates in the pathway for biotin biosynthesis. The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyses an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8-diaminononanoate (cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase)." +"2.6.1.106","A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction." +"2.6.1.107",Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin. +"2.6.99.4","The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg [3]. " +"2.7.1.181","The enzyme is involved in the biosynthesis of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a. O-Polysaccharide structures vary extensively because of differences in the number and type of sugars in the repeat unit. The dual kinase/methylase WbdD also catalyses the methylation of 3-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.1.1.294, 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase)." +"2.7.1.182",The enzyme is found in plants and photosynthetic algae [2] and is involved in phytol salvage [1]. It can use UTP as an alternative phosphate donor with lower activity [2]. +"2.8.3.20","The enzyme, purified from the bacterium Clostridium tetanomorphum, can also accept itaconate as acceptor, with lower efficiency." +"2.8.3.21",The enzyme is found in gammaproteobacteria such as Proteus sp. and Escherichia coli. It has similar activity with both substrates. +"2.8.3.22","The enzyme, purified from the bacterium Chloroflexus aurantiacus, can also accept itaconate as acceptor, with lower efficiency. It is part of the 3-hydroxypropanoate cycle for carbon assimilation." +"2.8.4.3","This bacterial enzyme binds two [4Fe-4S] clusters as well as the transferred sulfur [3]. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover. The identity of the electron donor is not known." +"2.8.4.4","This bacterial enzyme binds two [4Fe-4S] clusters [2,3]. A bridge of five sulfur atoms is formed between the free Fe atoms of the two [4Fe-4S] clusters [6]. In the first reaction the enzyme transfers a methyl group from AdoMet to the external sulfur ion of the sulfur bridge. In the second reaction the enzyme catalyses the reductive fragmentation of a second molecule of AdoMet, yielding a 5'-deoxyadenosine radical, which then attacks the methylated sulfur atom of the polysulfide bridge, resulting in the transfer of a methylsulfanyl group to aspartate89 [5,6]. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes." +"2.8.4.5","The enzyme, which is a member of the S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes superfamily, binds two [4Fe-4S] clusters as well as the transferred sulfur. The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover. The identity of the electron donor is not known." +"3.1.2.30","Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters." +"3.1.3.93","The enzyme from plants also has the activity of EC 3.1.3.25, inositol-phosphate phosphatase. The enzymes have very low activity with D-galactose 1-phosphate (cf. EC 3.1.3.94, D-galactose 1-phosphate phosphatase)." +"3.1.3.94","The human enzyme also has the activity of EC 3.1.3.25, inositol-phosphate phosphatase. The enzyme has very low activity with L-galactose 1-phosphate (cf. EC 3.1.3.93, L-galactose 1-phosphate phosphatase)." +"3.1.3.95",The enzyme is found in both plants and animals. It also has the activity of EC 3.1.3.64 (phosphatidylinositol-3-phosphatase). +"3.1.21.8","Requires Mg2+. This phage T4 enzyme is involved in degradation of host DNA. The enzyme primarily catalyses nicking of the bottom strand of double stranded DNA between the first and second base pair to the right of a top-strand CCGC motif. Double-stranded breaks are produced 5- to 10-fold less frequently [3]. It does not cleave the T4 native DNA, which contains 5-hydroxymethylcytosine instead of cytosine." +"3.1.21.9","This phage T4 enzyme is involved in degradation of host DNA. The enzyme does not cleave double-stranded DNA or native T4 DNA, which contains 5-hydroxymethylcytosine instead of cytosine." +"3.2.1.191","Ginsenosidase type III catalyses the sequential hydrolysis of the 3-O-beta-D-(1->2)-glucopyranosyl bond followed by hydrolysis of the 3-O-beta-D-glucopyranosyl bond of protopanaxadiol ginsenosides. When acting for example on ginsenoside Rb1 the enzyme first generates ginsenoside XVII, and subsequently ginsenoside LXXV." +"3.2.1.192","Ginsenosidases catalyse the hydrolysis of glycosyl moieties attached to the C-3, C-6 or C-20 position of ginsenosides. They are specific with respect to the nature of the glycosidic linkage, the position and the order in which the linkages are cleaved. Ginsenoside Rb1 beta-glucosidase specifically and sequentially hydrolyses the 20-[beta-D-glucopyranosyl-(1->6)-beta-D glucopyranosyloxy] residues attached to position 20 by first hydrolysing the (1->6)-glucosidic bond to generate ginsenoside Rd as an intermediate, followed by hydrolysis of the remaining 20-O-beta-D-glucosidic bond. " +"3.2.1.193","Ginsenosidase type I is slightly activated by Mg2+ or Ca2+ [1]. The enzyme hydrolyses the 3-O-beta-D-(1->2)-glucosidic bond, the 3-O-beta-D-glucopyranosyl bond and the 20-O-beta-D-(1->6)-glycosidic bond of protopanaxadiol-type ginsenosides. It usually leaves a single glucosyl residue attached at position 20 and one or no glucosyl residues at position 3. Starting with a ginsenoside that is glycosylated at both positions (e.g. ginsenoside Rb1, Rb2, Rb3, Rc or Rd), the most common products are ginsenoside F2 and ginsenoside C-K, with low amounts of ginsenoside Rh2." +"3.2.1.194","Ginsenosidase type IV catalyses the sequential hydrolysis of the 6-O-beta-D-(1->2)-glycosidic bond or the 6-O-alpha-D-(1->2)-glycosidic bond in protopanaxatriol-type ginsenosides with a disacchride attached to the C6 position, followed by the hydrolysis of the remaining 6-O-beta-D-glycosidic bond (e.g. ginsenoside Re -> ginsenoside Rg1 -> ginsenoside F1)." +"3.2.1.195","The 20-O-multi-glycoside ginsenosidase catalyses the hydrolysis of the 20-O-alpha-(1->6)-glycosidic bond and the 20-O-beta-(1->6)-glycosidic bond of protopanaxadiol-type ginsenosides. The enzyme usually leaves a single glucosyl residue attached at position 20, although it can cleave the remaining glucosyl residue with a lower efficiency. Starting with a ginsenoside that is glycosylated at positions 3 and 20, such as ginsenosides Rb1, Rb2, Rb3 and Rc, the most common product is ginsenoside Rd, with a low amount of ginsenoside Rg3 also formed." +"3.2.2.30","The enzyme, found in several bacterial species, catalyses a step in a modified futalosine pathway for menaquinone biosynthesis. While the enzyme from some organisms also has the activity of EC 3.2.2.9, adenosylhomocysteine nucleosidase, the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine [7]." +"3.5.1.116","This plant enzyme is involved in the degradation of ureidoglycolate, an intermediate of purine degradation. Not to be confused with EC 4.3.2.3, ureidoglycolate lyase, which releases urea rather than ammonia." +"3.5.4.40","The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis." +"3.5.99.10","This enzyme, which has been found in all species and tissues examined, catalyses the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19, threonine ammonia-lyase and EC 4.3.1.17, L-serine ammonia-lyase. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates." +"3.7.1.21","The enzyme, which participates in the anaerobic benzoyl-CoA degradation pathway in certain organisms, catalyses the addition of one molecule of water to the double bound of 6-oxocyclohex-1-ene-1-carbonyl-CoA followed by the hydrolytic C-C cleavage of the alicyclic ring." +"3.7.1.22","The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol degradation pathway leading to acetyl-CoA." +"4.1.1.97","This enzyme is part of the pathway from urate to (S)-allantoin, which is present in bacteria, plants and animals (but not in humans)." +"4.1.2.55","In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. In vitro the enzyme can also catalyse the cleavage of the non-phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with much lower catalytic efficiency. cf. EC 4.1.2.21, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, and EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase." +"4.1.2.56","Part of the pathway for the biosynthesis of grixazone, a mixture of yellow pigments produced by the bacterium Streptomyces griseus." +"4.1.3.46","Requires Mn2+ ions for activity. The enzyme, purified from the bacterium Chloroflexus aurantiacus, has no activity with (3S)-citramalyl-CoA (cf. EC 4.1.3.25, (S)-citramalyl-CoA lyase)." +"4.2.1.147",Found in methylotrophic bacteria and methanogenic archaea. +"4.2.1.148",The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation. +"4.2.1.149","The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2]." +"4.2.1.150","The enzyme from the bacterium Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents. It is specific for short, C4-C6, chain length substrates and exhibits an extremely high turnover number for crotonyl-CoA. cf. EC 4.2.1.17, enoyl-CoA hydratase and EC 4.2.1.74, long-chain-enoyl-CoA hydratase." +"4.2.1.151","The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis." +"4.3.1.30","The enzyme, which is a member of the 'AdoMet radical' (radical SAM) family, is involved in biosynthesis of TDP-alpha-D-desosamine. The reaction starts by the transfer of an electron from the reduced form of the enzyme's [4Fe-4S] cluster to S-adenosyl-L-methionine, spliting it into methionine and the radical 5-deoxyadenosin-5'-yl, which attacks the sugar substrate. " +"4.6.1.16",The enzyme catalyses the final stage in the maturation of tRNA molecules. +"5.1.3.28",Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Involved in bacterial polysaccharide biosynthesis. +"5.3.1.30","The enzyme, found in the bacterium Bacillus subtilis, is part of a myo-inositol degradation pathway leading to acetyl-CoA." +"5.3.99.11","Requires a divalent metal ion for activity. Mn2+, Fe2+ and Co2+ can be used. The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA." +"5.4.1.3","The enzyme, purified from the bacterium Chloroflexus aurantiacus, acts as an intramolecular CoA transferase and does not transfer CoA to free mesaconate. It is part of the 3-hydroxypropanoate cycle for carbon assimilation." +"5.4.99.60","The enzyme, which participates in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of cobalt-precorrin-8 to cobyrinate by methyl rearrangement. The equivalent enzyme in the aerobic pathway is EC 5.4.99.61, precorrin-8X methylmutase." +"5.4.99.61","The enzyme, which participates in the aerobic (late cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of precorrin-8X to hydrogenobyrinate by methyl rearrangement. The equivalent enzyme in the anaerobic pathway is EC 5.4.99.60, cobalt-precorrin-8 methylmutase." +"6.2.1.40","Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle. cf. EC 6.2.1.56, 4-hydroxybutyrate---CoA ligase (ADP-forming)." +"6.3.1.17","The enzyme, found in animals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase." +"6.3.2.41","The enzyme, found in animals, produces the neurotransmitter N-acetyl-L-aspartyl-L-glutamate. One isoform also has the activity of EC 6.3.1.17, beta-citrylglutamate synthase [2], while another isoform has the activity of EC 6.3.2.42, N-acetylaspartylglutamylglutamate synthase [3]." +"6.3.2.42","The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase." +"1.1.1.374",The enzyme from the archaeon Methanococcus maripaludis is activated by KCl (200 mM). +"1.1.1.372","The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction." +"1.1.1.373","The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea." +"1.1.3.46","A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics." +"1.3.99.36","Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide." +"1.5.1.48", The enzyme from the bacterium Streptomyces sp. GF3587 is highly specific for its substrate and forms only the (R) isomer. +"1.10.3.15","A type 3 multi copper protein. The enzyme, isolated from the bacterium Streptomyces griseus, catalyses an 8 electron oxidation. Activation of the enzyme requires a copper chaperone (GriE). It also acts on 3-amino-4-hydroxybenzaldehyde, giving grixazone A. The second aldehyde group is presumably lost as formate. The enzyme also catalyses the reaction of EC 1.10.3.4 o-aminophenol oxidase." +"1.11.1.23","This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate [7]." +"1.11.2.5","The heme-containing peroxygenase from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family. " +"1.13.11.78","Requires Fe2+. The enzyme, characterized from a marine bacterium, is involved in a 2-aminoethylphosphonate degradation pathway." +"1.13.11.79","The enzyme catalyses a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12. This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor [4]. The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH2 and 2-H from the ribityl 1'-pro-S hydrogen. While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet." +"1.14.11.45","The enzyme, characterized from the bacterium Bacillus thuringiensis, can also catalyse the hydroxylation of L-leucine, L-norvaline, L-norleucine, and L-allo-isoleucine, as well as the sulfoxidation of L-methionine, L-ethionine, S-methyl-L-cysteine, S-ethyl-L-cysteine, and S-allyl-L-cysteine." +"1.14.11.46","Requires Fe2+ and ascorbate. The enzyme, characterized from an uncultured marine bacterium, is involved in a (2-aminoethyl)phosphonate degradation pathway." +"1.14.13.189","The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B. " +"1.14.13.190","The enzyme is found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant." +"1.14.13.191","A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Participates in the pathway for the biosynthesis of oryzalexins, a group of related phytoalexins produced by rice." +"1.14.13.192",A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Oryzalexin E is a phytoalexin. +"1.14.13.193",A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Oryzalexin D is a phytoalexin. +"1.14.13.194","A heme-thiolate protein (cytochrome P-450). Isolated from human tissue. The enzyme will also act on menaquinone-4. Prolonged action of CYP4F2, but not CYP4F11, on the omega hydroxyl group oxidizes it to the corresponding carboxylic acid. CYP4F2 also oxidizes leukotriene B4; see EC 1.14.13.30, leukotriene-B4 20-monooxygenase [1]." +"1.14.14.15",The enzyme from the bacterium Streptomyces globisporus is involved in the biosynthesis of the (S)-3-chloro-5-hydroxy-beta-tyrosine moiety prior to incorporation into the chromoprotein antitumor antibiotic C-1027. +"1.14.16.7","The enzyme, characterized from the bacterium Streptomyces coeruleorubidus, forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine), which is one of the building blocks in the biosynthesis of the uridyl peptide antibiotics pacidamycins. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine." +"1.16.3.2","Ferritins are intracellular iron-storage and detoxification proteins found in all kingdoms of life. They are formed from two subunits that co-assemble in various ratios to form a spherical protein shell. Thousands of mineralized iron atoms are stored within the core of the structure. The product of dioxygen reduction by the bacterial non-heme ferritin is hydrogen peroxide, which is consumed in a subsequent reaction." +"2.1.1.301","The enzyme, isolated from the bacterium Streptomyces sp. OH-4156, can methylate a variety of linear oligopeptides, cyclic peptides such as nisin and haloduracin, and the epsilon-amino group of lysine [2]. Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. " +"2.1.1.302","The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B. " +"2.1.1.303","The enzyme from the bacterium Streptomyces carzinostaticus is involved in the biosynthesis of 2-hydroxy-7-methoxy-5-methyl-1-naphthoate. This compound is part of the enediyne chromophore of the antitumor antibiotic neocarzinostatin. In vivo the enzyme catalyses the regiospecific methylation at the 7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1-naphthoate. In vitro it also recognizes other dihydroxynaphthoic acids and catalyses their regiospecific O-methylation. " +"2.1.1.304","The enzyme from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family. " +"2.1.1.305",The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin. +"2.1.1.306",The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin. +"2.1.1.307",The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin. +"2.3.1.233","Isolated from the fungus Colletotrichum lagenarium [1], and the bacteria Streptomyces coelicolor [2,3] and Streptomyces peucetius [4]. It only uses malonyl-CoA, without invovement of acetyl-CoA." +"2.4.1.325",Involved in the enterobacterial common antigen (ECA) biosynthesis in the bacterium Escherichia coli. The trisaccharide of the product (lipid III) is the repeat unit of ECA. +"2.4.1.326","Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-beta-L-fucose. Involved in the biosynthesis of other aclacinomycins." +"2.4.1.327","The enzyme, isolated from the bacterium Streptomyces galilaeus, is involved in the biosynthesis of other aclacinomycins. Also acts on idarubicin. It will slowly add a second 2-deoxy-L-fucose unit to aclacinomycin S in vitro." +"2.4.1.328",Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin. +"2.5.1.121","The enzyme is involved in the biosynthesis of prenylated phenazines by the bacterium Streptomyces anulatus. It is specific for both prenyl diphosphate and 5,10-dihydrophenazine-1-carboxylate." +"2.5.1.122",The enzyme is involved in biosynthesis of the phytotoxin sirodesmin PL by the phytopathogenic ascomycete Leptosphaeria maculans. +"2.5.1.123",Does not require Mg2+ or any other metal ions. Isolated from the bacterium Streptomyces cinnamonensis. In vitro the enzyme also forms traces of 3-geranylflaviolin. +"2.7.1.183","In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity." +"2.7.1.184","The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea." +"2.8.2.37",The sulfation of trehalose in the bacterium Mycobacterium tuberculosis is required for the biosynthesis of sulfolipid-1. +"3.1.1.96","The enzyme, found in all domains of life, can cleave mischarged glycyl-tRNAAla [5]. The enzyme from Escherichia coli can cleave D-tyrosyl-tRNATyr, D-aspartyl-tRNAAsp and D-tryptophanyl-tRNATrp [1]. Whereas the enzyme from the archaeon Pyrococcus abyssi is a zinc protein, the enzyme from Escherichia coli does not carry any zinc [2]." +"3.1.4.57","The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate." +"3.1.12.1","Preference for single-stranded DNA. The enzyme from the archaeon Sulfolobus solfataricus contains a [4Fe-4S] cluster and requires a divalent metal cation, such as Mg2+ or Mn2+, for activity. " +"3.5.1.117","The enzyme is involved in degradation of nylon-6 oligomers. It degrades linear or cyclic oligomers of poly(6-aminohexanoate) with a degree of polymerization greater than three (n > 3) by endo-type cleavage, to oligomers of a length of two or more (2 <= x < n). It shows negligible activity with N-(6-aminohexanoyl)-6-aminohexanoate (cf. EC 3.5.1.46, 6-aminohexanoate-oligomer exo hydrolase) or with 1,8-diazacyclotetradecane-2,9-dione (cf. EC 3.5.2.12, 6-aminohexanoate-cyclic-dimer hydrolase). " +"3.13.1.4",The enzyme from the beta-proteobacterium Advenella mimigardefordensis contains one non-covalently bound FAD per subunit. +"4.1.1.98","The enzyme catalyses a step in prokaryotic ubiquinone biosynthesis, as well as in plastoquinone biosynthesis in cyanobacteria. The enzyme can accept substrates with different polyprenyl tail lengths in vitro, but uses a specific length in vivo, which is determined by the polyprenyl diphosphate synthase that exists in the specific organism. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase." +"4.1.2.57","The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea." +"4.2.1.153",The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation. +"4.2.1.154",The enzyme is involved in biosynthesis of the anthracycline antibiotic tetracenomycin C by the bacterium Streptomyces glaucescens. +"4.2.3.145",Isolated from the fungus Aspergillus clavatus. The product is a sesterterpenoid (C25 terpenoid). +"4.2.3.146","Requires Mg2+. Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase." +"5.1.3.29","This enzyme shows no 1-epimerase activity with D-glucose, L-rhamnose and D-fucose (cf. EC 5.1.3.3, aldose 1-epimerase) [1]. " +"5.3.1.31","The enzyme, characterized from the bacterium Escherichia coli, is involved in the degradation pathway of sulfoquinovose, the polar headgroup of sulfolipids found in the photosynthetic membranes of all higher plants, mosses, ferns, algae, and most photosynthetic bacteria, as well as the surface layer of some archaea." +"5.4.4.7","Binds Fe2+. The enzyme from mammals accepts a range of hydroperoxyicosatetraenoates producing one or several different hydroxyepoxyicosatrienoates. The human enzyme has highest activity with (12R)-HPETE producing (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate, followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate [1]. The mouse enzyme has highest activity with (8S)-HPETE, producing (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate [2]. The enzymes also have the activity of EC 4.2.1.152, hydroperoxy icosatetraenoate dehydratase." +"6.1.2.2",Requires Fe(III). The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin. +"6.2.1.41","The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol and cholate. The enzyme is very specific for its substrate, and requires that the side chain at C17 is completely removed." +"6.2.1.42","The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol. It is responsible for the activation of the C8 side chain. 3beta-hydroxycholest-5-en-26-oate can also be used as substrate." +"6.2.1.43","The enzyme from the bacterium Streptomyces carzinostaticus is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1-naphthoate moiety of the antibiotic neocarzinostatin. In vitro the enzyme also catalyses the activation of other 1-naphthoic acid analogues, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate." +"6.3.1.18","Requires Mg2+. The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the first step in the degradation of aniline. It can also accept chlorinated and methylated forms of aniline, preferrably in the o- and p-positions." +"1.1.1.375","The enzyme from the archaeon Methanocaldococcus jannaschii catalyses the reversible oxidation of (2R)-3-sulfolactate and (S)-malate to 3-sulfopyruvate and oxaloacetate, respectively (note that (2R)-3-sulfolactate has the same stereochemical configuration as (2S)-2-hydroxycarboxylates) [1]. The enzyme can use both NADH and NADPH, although activity is higher with NADPH [1-3]. The oxidation of (2R)-3-sulfolactate was observed only in the presence of NADP+ [1]. The same organism also possesses an NAD+-specific enzyme with similar activity, cf. EC 1.1.1.337, L-2-hydroxycarboxylate dehydrogenase (NAD+)." +"1.1.1.376","The enzymes from the bacterium Azospirillum brasilense and the archaeon Haloferax volcanii are part of the L-arabinose degradation pathway and prefer NADP+ over NAD+. In vitro the enzyme from Azospirillum brasilense shows also high catalytic efficiency with D-galactose. The enzyme is specific for alpha-L-arabinopyranose [3,4]." +"1.1.1.377","The enzyme from the archaeon Thermoplasma acidophilum is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+. " +"1.1.1.378","The enzyme, which occurs in the bacteria Azotobacter vinelandii and Sphingomonas sp. SKA58, is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+ and EC 1.1.1.377, L-rhamnose 1-dehydrogenase (NADP+). " +"1.2.99.9",The enzyme from methanogenic archaea is a involved in formate-dependent H2 production. It contains noncovalently bound FAD [1]. +"1.3.1.107","The enzyme, purified from the California poppy (Eschscholzia californica), is involved in detoxifying the phytoalexin sanguinarine produced by poppy itself (cf. EC 1.5.3.12, dihydrobenzophenanthridine oxidase), when it binds to the cell wall of the poppy cell. The reaction with NADPH is up to three times faster than that with NADH at low concentrations (<10 uM) of the dinucleotide. At higher concentrations the reaction with NADPH is inhibited but not that with NADH [1]." +"1.3.4.1","The enzyme, isolated from the archaeon Methanobacterium thermoautotrophicum, is very oxygen sensitive. It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as an electron donor. Distinct from EC 1.3.1.6 [fumarate reductase (NADH)] and EC 1.3.5.1 [succinate dehydrogenase (ubiquinone)]." +"1.5.99.15","This archaeal enzyme catalyses the last step in the biosynthesis of tetrahydromethanopterin, a folate analogue used in methanogenesis. The enzyme, characterized from the archaea Methanosarcina mazei and Methanocaldococcus jannaschii, is an iron-sulfur flavoprotein. cf. EC 1.5.1.47, dihydromethanopterin reductase [NAD(P)+]." +"1.8.98.3","The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, is involved in sulfite detoxification and assimilation." +"1.14.11.47","The enzyme, characterized from the bacterium Escherichia coli, hydroxylates an arginine residue on the 50S ribosomal protein L16, and is involved in regulation of bacterial ribosome assembly." +"1.14.13.195","A flavoprotein (FAD). The enzyme is involved in biosynthesis of N5-hydroxy-L-ornithine, N5-formyl-N5-hydroxy-L-ornithine or N5-acetyl-N5-hydroxy-L-ornithine. These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa). The enzyme is specific for NADPH. cf. EC 1.14.13.196, L-ornithine N5-monooxygenase [NAD(P)H]." +"1.14.13.196","A flavoprotein (FAD). The enzyme from the pathogenic fungus Aspergillus fumigatus catalyses a step in the biosynthesis of the siderophores triacetylfusarinine and desferriferricrocin, while the enzyme from the bacterium Kutzneria sp. 744 is involved in the biosynthesis of piperazate, a building block of the kutzneride family of antifungal antibiotics. Activity of the fungal enzyme is higher with NADPH, due to the fact that following the reduction of the flavin, NADP+ (but not NAD+) stabilizes the C4a-hydroperoxyflavin intermediate that oxidizes the substrate [3]. cf. EC 1.14.13.195, L-ornithine N5-monooxygenase (NADPH). " +"1.14.13.197","A heme-thiolate protein (cytochrome P-450). The dehydration of 3alpha-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous [1,2]. The enzyme from fungi also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase [3]." +"1.14.13.198","A heme-thiolate protein (cytochrome P-450). The enzyme from fungi also catalyses the reaction of EC 1.14.13.197, dihydromonacolin L hydroxylase." +"1.14.13.199",Isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid. +"1.14.13.200","Isolated from the bacterium Streptomyces glaucescens. The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis. The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide. Water opens the epoxide giving two hydroxy groups. The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group." +"1.14.19.9","A flavin-dependent halogenase. The enzyme from the bacterium Lechevalieria aerocolonigenes catalyses the initial step in the biosynthesis of rebeccamycin [2]. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. Also acts on bromide ion. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.59, tryptophan 6-halogenase." +"1.14.99.49",A heme-thiolate protein (P-450) enzyme involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus. +"2.4.1.329","The enzyme, isolated from the thermophilic bacterium Thermoanaerobacterium thermosaccharolyticum, catalyses the reversible phosphorolysis of sucrose 6F-phosphate. It also acts on sucrose with lower activity." +"2.4.1.330","The enzyme, characterized from the plant Gardenia jasminoides, adds a glucose to several crocetin glycosyl esters, but not to crocetin (cf. EC 2.4.1.271, crocetin glucosyltransferase). " +"2.4.1.331",Isolated from Streptomyces olivaceus Tu2353. Involved in elloramycin biosynthesis. In vitro it can also utilize other 6-deoxy D- or L-hexoses. +"2.5.1.124","The enzyme is involved in biosynthesis of the polyketide-isoprenoid furaquinocin D in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 6-linalyl-2-O,3-dimethylflaviolin and 7-O-geranyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.125, 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase) in a 10:1 ratio." +"2.5.1.125","The enzyme is involved in furaquinocin biosynthesis in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 7-O-geranyl-2-O,3-dimethylflaviolin and 6-linalyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.124, 6-linalyl-2-O,3-dimethylflaviolin synthase) in a 1:10 ratio. " +"2.5.1.126","The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3-diamine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.127, caldopentamine synthase, this enzyme does not accept norspermine as a substrate." +"2.5.1.127","The enzyme, characterized from the thermophilic archaeon Hyperthermus butylicus, can also synthesize norspermine from norspermidine and thermospermine from spermidine (with lower activity). The long-chain polyamines stabilize double-stranded DNA at high temperatures. In contrast to EC 2.5.1.23, sym-norspermidine synthase and EC 2.5.1.126, norspermine synthase, this enzyme shows no activity with propane-1,3-diamine. " +"2.7.1.185","Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea. " +"2.7.1.186",Mevalonate 3-kinase (EC 2.7.1.185) and mevalonate-3-phosphate-5-kinase act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. +"2.7.14.1","The enzyme, characterized from Gram-positive bacteria, is involved in the regulation of the bacterial stress response." +"3.5.4.41",The enzyme from the archaeon Methanocaldococcus jannaschii is involved in the recycling of 5'-deoxyadenosine. +"3.9.1.2","The enzyme, characterized from Gram-positive bacteria, hydrolyses the phosphoramidate (P-N) bond of Nomega-phospho-L-arginine residues in proteins and peptides that were phosphorylated by EC 2.7.14.1, protein arginine kinase." +"4.1.1.99","The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase." +"4.2.3.147",Isolated from the plants Pinus banksiana (jack pine) and Pinus contorta (lodgepole pine). +"5.1.3.30","The enzyme is highly specific for D-psicose and shows very low activity with D-tagatose (cf. EC 5.1.3.31, D-tagatose 3-epimerase). The enzyme from the bacterium Clostridium scindens requires Mn2+ [1], whereas the enzymes from the bacteria Clostridium cellulolyticum [2,5], Clostridium sp. BNL1100 [3], and Clostridium bolteae [4] require Co2+ as optimum cofactor. The enzyme from Ruminococcus sp. [6] is not dependent on the presence of metal ions, but its activity is enhanced by Mn2+." +"5.1.3.31","The enzymes isolated from the bacteria Pseudomonas cichorii [2], Pseudomonas sp. ST-24 [1], Rhodobacter sphaeroides [3] and Mesorhizobium loti [4] catalyse the epimerization of various ketoses at the C-3 position, interconverting D-fructose and D-psicose, D-tagatose and D-sorbose, D-ribulose and D-xylulose, and L-ribulose and L-xylulose. The specificity depends on the species. The enzymes from Pseudomonas cichorii and Rhodobacter sphaeroides require Mn2+ [2,3]." +"5.1.3.32",The enzyme is specific for L-rhamnopyranose. +"5.4.99.62",The enzyme also catalyses the conversion between beta-allopyranose and beta-allofuranose. +"6.1.1.28","The enzyme attaches two different amino acids, proline and cysteine, to their cognate tRNAs. It has been characterized from the archaea Methanocaldococcus jannaschii and Methanococcus maripaludis, the protozoan parasite Giardia intestinalis, and the thermophilic bacterium Thermus thermophilus." +"6.2.1.44","The enzyme is part of a dimethylsulfoniopropanoate demethylation pathway in the marine bacteria Ruegeria pomeroyi and Pelagibacter ubique. It also occurs in some nonmarine bacteria capable of metabolizing dimethylsulfoniopropionate (e.g. Burkholderia thailandensis, Pseudomonas aeruginosa, and Silicibacter lacuscaerulensis). It requires Mg2+ [2]." +"6.3.2.43",The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW. This reaction is part of the lysine biosynthesis pathway in these organisms. +"6.3.2.44","The enzyme, characterized from the archaeon Methanosarcina mazei, is involved in the biosynthesis of pantothenate. It is different from EC 6.3.2.1, the AMP-forming pantoate-beta-alanine ligase found in bacteria and eukaryota. " +"6.5.1.6","The enzymes from the archaea Thermococcus fumicolans and Thermococcus onnurineus show high activity with either ATP or NAD+, and significantly lower activity with TTP, GTP, and CTP. The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP or NAD+, forming a phosphoramide bond between adenylate and a lysine residue. The adenylate group is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the adenylate. Different from EC 6.5.1.1, DNA ligase (ATP), EC 6.5.1.2, DNA ligase (NAD+) and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP)." +"6.5.1.7","The enzymes from the archaea Hyperthermus butylicus and Sulfophobococcus zilligii are active with ATP, ADP or GTP. They show no activity with NAD+. The enzyme catalyses the ligation of DNA strands with 3'-hydroxyl and 5'-phosphate termini, forming a phosphodiester and sealing certain types of single-strand breaks in duplex DNA. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, ADP, or GTP, forming a phosphoramide bond between adenylate/guanylate and a lysine residue. The nucleotide is then transferred to the 5'-phosphate terminus of the substrate, forming the capped structure 5'-(5'-diphosphoadenosine/guanosine)-[DNA]. Finally, the enzyme catalyses a nucleophilic attack of the 3'-OH terminus on the capped terminus, which results in formation of the phosphodiester bond and release of the nucleotide. Different from EC 6.5.1.1, DNA ligase (ATP), and EC 6.5.1.6, DNA ligase (ATP or NAD+), which cannot utilize GTP." +"1.1.1.379","The enzyme, found in bacteria and fungi, can also accept a number of substituted mandelate derivatives, such as 3-hydroxymandelate, 4-hydroxymandelate, 2-methoxymandelate, 4-hydroxy-3-methoxymandelate and 3-hydroxy-4-methoxymandelate. The enzyme has no activity with (S)-mandelate (cf. EC 1.1.99.31, (S)-mandelate dehydrogenase) [1,2]. The enzyme transfers the pro-R-hydrogen from NADH [2]." +"1.1.1.380","The enzyme, characterized from the bacterium Halomonas elongata, participates in a pathway for L-gulonate degradation." +"1.1.1.381","The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase)." +"1.1.3.47","The enzyme, characterized from the bacterium Methylovorus sp. strain MP688, is involved in the degradation and detoxification of 5-(hydroxymethyl)furfural. The enzyme acts only on alcohol groups and requires the spontaneous hydration of aldehyde groups for their oxidation [3]. The enzyme has a broad substrate range that overlaps with EC 1.1.3.7, aryl-alcohol oxidase." +"1.2.1.90",The enzyme is part of the modified Embden-Meyerhof-Parnas pathway of the archaeon Thermoproteus tenax. cf. EC 1.2.1.9 [glyceraldehyde-3-phosphate dehydrogenase (NADP+)]. +"1.2.1.91","The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 3.3.2.12, oxepin-CoA hydrolase. Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway." +"1.2.1.92","The enzyme, characterized from the marine bacterium Vibrio sp. EJY3, is involved in a degradation pathway for 3,6-anhydro-alpha-L-galactose, a major component of the polysaccharides produced by red macroalgae, such as agarose and porphyran." +"1.9.98.1","The MtrC and OmcA proteins of the bacterium Shewanella oneidensis MR-1 are decaheme c-type cytochromes that reduce iron oxides extracellularly, passing the electrons to MtrA, another decaheme c-type cytochrome located in the periplasm." +"1.17.4.4","The enzyme catalyses the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, peptidyl-glutamate 4-carboxylase, back to its phylloquinol active form. The enzyme forms a tight complex with EC 5.3.4.1, protein disulfide-isomerase, which transfers the required electrons from newly-synthesized proteins by catalysing the formation of disulfide bridges. The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2). Inhibited strongly by (S)-warfarin and ferulenol." +"1.17.4.5","Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)]." +"1.17.98.1","Under physiological conditions, the reactions form deoxycholate. This enzyme is highly specific for bile-acid substrates and requires a free C-24 carboxy group and an unhindered 7alpha-hydroxy group on the B-ring of the steroid nucleus for activity, as found in cholate and chenodeoxycholate. The reaction is stimulated by the presence of NAD+ but is inhibited by excess NADH. This unusual regulation by the NAD+/NADH ratio is most likely the result of the intermediates being linked at C-24 by an anhydride bond to the 5'-diphosphate of 3'-phospho-ADP [2,5,6]. Allodeoxycholate is also formed as a side-product of the 7alpha-dehydroxylation of cholate [6]. The enzyme is present in intestinal anaerobic bacteria [6], even though its products are important in mammalian physiology." +"1.17.99.6","This enzyme catalyses the last step in the bacterial biosynthetic pathway to queuosine, the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. Two types of enzymes are known to catalyse this activity. QueG enzymes are cobalamin-dependent, while QueH enzymes contain a [4Fe-4S] metallocluster along with an adjacent coordinated iron metal." +"1.21.98.1","This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis." +"2.1.1.308","Requires cobalamin. The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. It is a radical S-adenosyl-L-methionine (SAM) enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. The enzyme uses two molecues of SAM for the reaction. One molecule forms a 5'-deoxyadenosyl radical, while the other is used to methylate the cobalamin cofactor. The 5'-deoxyadenosyl radical abstracts a hydrogen from the C2 position of cytidine 5'-{[(2-hydroxyethyl)phosphonoyl]phosphate} forming a free radical that reacts with the methyl group on methylcob(III)alamin at the opposite side from SAM and the [4Fe-4S] cluster with inversion of configuration to produce the (S)-isomer of the methylated product and cob(III)alamin. Both the [4Fe-4S] cluster and the cob(III)alamin need to be reduced by an unknown factor(s) before the enzyme could catalyse another cycle." +"2.1.1.309","The enzyme, found in eukaryotes, is involved in pre-rRNA processing. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1]." +"2.1.1.310","The enzyme, found in eukaryotes, is specific for cytosine2870 of the 25S ribosomal RNA. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1]." +"2.1.1.311","The enzyme, found in eukaryotes, is specific for 25S cytosine2278. The numbering corresponds to the enzyme from the yeast Saccharomyces cerevisiae [1]." +"2.1.1.312","The enzyme, described from the yeast Saccharomyces cerevisiae, is involved in ribosome biogenesis." +"2.1.1.313","The enzyme, described from the yeast Saccharomyces cerevisiae, is involved in ribosome biogenesis." +"2.2.1.12","Requires thiamine diphosphate. The enzyme, characterized from the bacterium Serratia marcescens, participates in the biosynthesis of the antibiotic prodigiosin. The enzyme decarboxylates pyruvate, followed by attack of the resulting two-carbon fragment on (E)-oct-2-enal, resulting in a Stetter reaction. In vitro the enzyme can act on a number of alpha,beta-unsaturated carbonyl compounds, including aldehydes and ketones, and can catalyse both 1-2 and 1-4 carboligations depending on the substrate." +"2.3.1.234","The enzyme is involved in the synthesis of N6-threonylcarbamoyladenosine37 in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNAIle, tRNAThr, tRNAAsn, tRNALys, tRNASer and tRNAArg [3]. " +"2.3.1.235","A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens. It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules." +"2.3.1.236",A multi-domain polyketide synthase involved in the synthesis of azinomycin B in the bacterium Streptomyces griseofuscus. +"2.3.1.237",A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus. +"2.3.1.238",The enzyme catalyses the ultimate reaction in the lovastatin biosynthesis pathway of the filamentous fungus Aspergillus terreus. +"2.3.1.239","The product, 10-deoxymethynolide, contains a 12-membered ring and is an intermediate in the biosynthesis of methymycin in the bacterium Streptomyces venezuelae. The enzyme also produces narbonolide (see EC 2.3.1.240, narbonolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis." +"2.3.1.240","The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae. The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239, 10-deoxymethynolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis." +"2.3.1.241","The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A. It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached to the nitrogen of the non-reducing glucosamine molecule. The enzyme from the bacterium Escherichia coli is specific for lauryl (C12) acyl groups, giving the enzyme its previous accepted name. However, enzymes from different species accept highly variable substrates." +"2.3.1.242","The enzyme, characterized from the bacterium Escherichia coli, is induced upon cold shock and is involved in the formation of a cold-adapted variant of the outer membrane glycolipid lipid A. " +"2.3.1.243","The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A. It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached at the 2-O position of the non-reducing glucosamine molecule. The enzyme from the bacterium Escherichia coli is specific for myristoyl (C14) acyl groups, giving the enzyme its previous accepted name. However, enzymes from different species accept highly variable substrates." +"2.4.1.332",The enzyme has been isolated from the bacterium Bacillus selenitireducens. In the absence of glycerol the enzyme produces alpha-D-glucopyranose and phosphate from beta-D-glucopyranose 1-phosphate. In this reaction the glucosyl residue is transferred to a water molecule with an inversion of the anomeric conformation. +"2.4.1.333",The enzyme has been isolated from the bacterium Listeria innocua. It catalyses the reversible phosphorolysis of beta-(1->2)-D-glucans. The minimum length of the substrate for the phosphorolytic reaction is 3 D-glucose units. In the synthetic reaction starting from sophorose and alpha-D-glucose 1-phosphate the average polymerisation degree is 39. +"2.4.1.334","The enzyme, isolated from the bacterium Clostridium phytofermentans, catalyses a reversible reaction. Substrates for the phosphorolytic reaction are alpha-1,3-linked oligoglucans with a polymerisation degree of 3 or more. Nigerose (i.e. 3-O-alpha-D-glucopyranosyl-D-glucopyranose) is not phosphorylyzed but can serve as substrate in the reverse direction (cf. EC 2.4.1.279, nigerose phosphorylase)." +"2.5.1.128","The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N4-bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. When spermine is used as substrate, the enzyme forms N4-aminopropylspermine. " +"3.1.1.97",The protein is only present in eukaryotes. +"3.1.3.96",Requires Mg2+ for activity. +"3.5.2.20","Requires Mn2+. This enzyme, found in several bacterial species, is involved in the degradation of indole-3-acetic acid." +"3.6.1.67","The enzyme participates in a folate biosynthesis pathway, which is found in bacteria, fungi, and plants. Requires Mg2+." +"4.2.3.148","Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This bifunctional enzyme also produces (R)-nephthenol. See EC 4.2.3.149, nephthenol synthase." +"4.2.3.149","Requires Mg2+. Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase)." +"4.2.3.150","Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol. See EC 4.2.3.149, nephthenol synthase and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase." +"4.2.3.151","Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This trifunctional enzyme, which contains a [4Fe-4S] cluster, also produces (R)-nephthenol and (R)-cembrene A. See EC 4.2.3.150, cembrene A synthase and EC 4.2.3.149, nephthenol synthase." +"4.4.1.28","The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster and is specific for L-cysteine (cf. EC 4.4.1.1, cystathionine gamma-lyase). It cleaves a carbon-sulfur bond releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The same reaction can also be catalysed by some pyridoxal-phosphate proteins (cf. EC 4.4.1.1, cystathionine gamma-lyase)." +"5.5.1.25","The enzyme, characterized from the marine bacteria Vibrio sp. EJY3 and Postechiella marina M091, is involved in a degradation pathway for 3,6-anhydro-alpha-L-galactopyranose, a major component of the polysaccharides of red macroalgae." +"6.3.2.45","The enzyme catalyses the reincorporation into peptidoglycan of the tripeptide L-alanyl-gamma-D-glutamyl-2,6-meso-diaminoheptanedioate released during the maturation and constant remodeling of this bacterial cell wall polymer that occur during cell growth and division. The enzyme can also use the tetrapeptide L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanyl-D-alanine in vivo and in vitro. Requires Mg2+. " +"6.3.4.24","The enzyme, which has been characterized from the archaea Methanocaldococcus fervens, participates in the biosynthesis of the cofactor methanofuran. Requires a divalent cation for activity, with Mn2+ giving the highest activity, followed by Mg2+, Co2+, Zn2+, and Fe2+." +"1.14.99.50","Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and gamma-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine." +"1.1.1.382","The enzyme, characterized from the bacteria Thermacetogenium phaeum and Desulfococcus oleovorans and from the archaeon Archaeoglobus fulgidus, is specific for NADH [cf. EC 1.1.1.86, ketol-acid reductoisomerase (NADP+) and EC 1.1.1.383, ketol-acid reductoisomerase [NAD(P)+]]." +"1.1.1.383","The enzyme, characterized from the bacteria Hydrogenobaculum sp. and Syntrophomonas wolfei subsp. wolfei and from the archaea Metallosphaera sedula and Ignisphaera aggregans, can use both NADH and NADPH with similar efficiency [cf. EC 1.1.1.86, ketol-acid reductoisomerase (NADP+) and EC 1.1.1.382, ketol-acid reductoisomerase (NAD+)]." +"1.1.1.384","The enzyme is involved in the biosynthesis of several deoxysugars, including L-digitoxose, L- and D-olivose, L-oliose, D-mycarose and forosamine." +"1.1.1.385","The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. " +"1.1.1.386","The enzyme is involved in pheromone production by the pine engraver beetle, Ips pini. " +"1.2.5.2","Wide specificity; acts on straight-chain aldehydes up to C10, aromatic aldehydes, glyoxylate and glyceraldehyde. The enzymes contains a PQQ cofactor and multiple hemes that deliver the electrons to the membrane quinone pool." +"1.2.98.1","The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein) [3]. Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors [1,2]." +"1.3.8.12","The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD. " +"1.5.1.49","The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH." +"1.6.5.11","Menaquinone can act as acceptor. Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives." +"1.10.5.1","A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3]." +"1.13.11.80","The enzyme, characterized from bacteria Streptomyces toyocaensis and Amycolatopsis orientalis, is involved in the biosynthesis of (3,5-dihydroxyphenyl)glycine, a component of the glycopeptide antibiotic vancomycin. " +"1.13.12.22","The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin. " +"1.14.11.48","Requires Fe2+ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine." +"1.14.13.201","The enzyme, found in plants, is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can also convert alpha-amyrin and lupeol to ursolic acid and betulinic acid, respectively. The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not catalyse the reaction to completion, resulting in accumulation of both intermediates." +"1.14.13.202","A heme-thiolate protein (cytochrome P-450). The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.13.203, farnesoate epoxidase) [1,2]. " +"1.14.13.203","A heme-thiolate protein (cytochrome P-450). The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.13.202, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone." +"1.14.19.10","The enzyme, characterized from the plant Limnanthes douglasii (meadowfoam), is involved in the biosynthesis of (5Z)-icos-5-enoate, an unusual monounsaturated fatty acid that makes up to 60% of the total fatty acids in Limnanthes sp. seed oil. The enzyme only acts on saturated fatty acids." +"1.23.5.1","Along with EC 1.14.15.21, zeaxanthin epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle for controlling the concentration of zeaxanthin in chloroplasts. It is activated by a low pH of the thylakoid lumen (produced by high light intensity). Zeaxanthin induces the dissipation of excitation energy in the chlorophyll of the light-harvesting protein complex of photosystem II. In higher plants the enzyme reacts with all-trans-diepoxides, such as violaxanthin, and all-trans-monoepoxides, but in the alga Mantoniella squamata, only the diepoxides are good substrates." +"2.1.1.314","This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98). The relevant histidine of elongation factor 2 is His715 in mammals and His699 in yeast. The order of the 4 methylations is not known." +"2.1.1.315","The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the antitubercular drug rifamycin B. " +"2.3.1.244","This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus. The overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta-enoyl reduction." +"2.3.1.245",The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2. +"2.3.1.246","The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine, a component of the vancomycin-type antibiotic balhimycin. " +"2.7.1.187","The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose. " +"2.7.1.188","The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose. " +"2.7.4.29",An inner-membrane protein. The activity of the enzyme is regulated by PmrA. In vitro the enzyme can use diacylglycerol 3-diphosphate as the phosphate donor. +"3.1.2.31","Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme." +"3.1.3.97","The enzyme, characterized from the bacterium Chromobacterium violaceum, has similar catalytic efficiencies with all the bases. The enzyme has similar activity with ribonucleoside and 2'-deoxyribonucleoside 3',5'-bisphosphates, but shows no activity with nucleoside 2',5'-bisphosphates (cf. EC 3.1.3.7, 3'(2'),5'-bisphosphate nucleotidase)." +"3.3.2.14","The enzyme, characterized from the bacterium Nocardioides sp. JS1661, is involved in the degradation of 2,4-dinitroanisole. Unlike other known O-demethylases, such as EC 1.14.99.15, 4-methoxybenzoate monooxygenase (O-demethylating), or EC 1.14.11.32, codeine 3-O-demethylase, it does not require oxygen or electron donors, and produces methanol rather than formaldehyde." +"3.4.14.13","The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the recycling of the murein peptide. " +"3.5.1.118",The enzyme is part of the biosynthesis pathway of ergothioneine in mycobacteria. +"4.1.1.100","The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme isomerizes only the pro-R double bond in prephenate. " +"4.1.99.21","The enzyme catalyses the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran. Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea." +"4.2.1.155","The enzyme is involved in the degradation of 3-(dimethylsulfonio)propanoate, an osmolyte produced by marine phytoplankton. Isolated from the bacterium Ruegeria pomeroyi." +"4.2.3.152","The enzyme is highly specific for alpha-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.155, 2-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase." +"4.4.1.29","The enzyme, found in cyanobacteria and red algae, catalyses the attachment of phycobilin chromophores to cysteine 84 of several phycobiliproteins (the numbering used here corresponds to the enzyme from Anabaena, in other organisms the number may vary slightly). It can attach phycocyanobilin to the beta subunits of C-phycocyanin and phycoerythrocyanin and to both subunits of allophycocyanin. In addition, it can attach phycoerythrobilin to both subunits of C-phycoerythrin." +"4.4.1.30","The enzyme, found in cyanobacteria and red algae, catalyses the attachment of the phycobilin chromophore phycocyanobilin to cysteine 155 of the beta subunits of the phycobiliproteins C-phycocyanin and phycoerythrocyanin. The numbering used here corresponds to the enzyme from Anabaena, and could vary slightly in other organisms. " +"4.4.1.31","The enzyme, characterized from the cyanobacteria Nostoc sp. PCC 7120 and Mastigocladus laminosus, catalyses the covalent attachment of the phycobilin chromophore phycocyanobilin to cysteine 84 of the beta subunit of the phycobiliprotein phycoerythrocyanin and its isomerization to phycoviolobilin." +"4.4.1.32","The enzyme, characterized from the cyanobacterium Synechococcus elongatus PCC 7942, catalyses the covalent attachment of the phycobilin chromophore phycocyanobilin to cysteine 84 of the alpha subunit of the phycobiliprotein C-phycocyanin." +"4.4.1.33","The enzyme, characterized from the cyanobacterium Synechococcus sp. WH8102, catalyses the covalent attachment of the phycobilin chromophore phycoerythrobilin to cysteine 84 of the alpha subunit of the phycobiliprotein R-phycocyanin and its isomerization to phycourobilin." +"5.1.1.20","The enzyme, characterized from the bacteria Escherichia coli and Bacillus subtilis, is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. In vitro the enzyme from Escherichia coli epimerizes several L-Ala-L-X dipeptides with broader specificity than the enzyme from Bacillus subtilis. " +"5.3.1.32",The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2. +"5.5.1.26","The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin." +"6.3.2.46","The enzyme, characterized from the bacterium Enterobacter agglomerans, is involved in biosynthesis of dapdiamide tripeptide antibiotics, a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the presence of an L-2,3-diaminopropanoate (DAP) moiety and two amide linkages in their scaffold." +"6.3.2.47","The enzyme, characterized from the bacterium Pantoea agglomerans, is involved in biosynthesis of dapdiamide tripeptide antibiotics, a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the presence of an (S)-2,3-diaminopropanoate (DAP) moiety and two amide linkages in their scaffold. " +"1.1.1.387","The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC 1.1.1.276, serine 3-dehydrogenase (NADP+)]." +"1.1.1.388","The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+). " +"1.1.3.48","The enzyme, characterized from the bacterium Shewanella oneidensis, is involved in the formation of 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate, an aminated form of Kdo found in lipopolysaccharides of members of the Shewanella genus. cf. EC 2.6.1.109, 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase." +"1.2.1.93","The enzyme complex, isolated from the bacterium Gottschalkia acidurici, couples the reduction of NAD+ and the reduction of ferredoxin with formate via flavin-based electron bifurcation. " +"1.2.1.94","Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito). " +"1.2.1.95","This enzyme, characterized from the yeast Saccharomyces cerevisiae, catalyses the reduction of L-2-aminoadipate to (S)-2-amino-6-oxohexanoate during L-lysine biosynthesis. An adenylation domain activates the substrate at the expense of ATP hydrolysis, and forms L-2-aminoadipate adenylate, which is attached to a peptidyl-carrier protein (PCP) domain. Binding of NADPH results in reductive cleavage of the acyl-S-enzyme intermediate, releasing (S)-2-amino-6-oxohexanoate. Different from EC 1.2.1.31, L-aminoadipate-semialdehyde dehydrogenase, which catalyses a similar transformation in the opposite direction without ATP hydrolysis." +"1.3.7.11","A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin [4]." +"1.3.99.37","The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the desaturation of the C-3,4 double bond in dihydroisopentenyldehydrorhodopin and the desaturation of the C-3',4' double bond in dihydrobisanhydrobacterioruberin. " +"1.4.99.6","Contains a non-covalent FAD cofactor. The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.1.25, L-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine. The enzyme has a broad substrate range and can act on most D-amino acids with the exception of D-glutamate and D-aspartate. However, activity is maximal with D-arginine and D-lysine. Not active on glycine." +"1.5.1.50","The enzyme, found in many Gram negative bacteria, also slowly reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). The enzyme has no activity with NADH." +"1.6.1.4","The iron-sulfur flavoprotein complex, originally isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH." +"1.8.99.5","Contain siroheme. The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. In sulfur reducers it catalyses the reduction of sulfite to sulfide (reaction 1 in the right to left direction), while in sulfur oxidizers it catalyses the opposite reaction (reaction 2 in the left to right direction) [1]. The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. During the process an intramolecular disulfide bond is formed between two L-cysteine residues of DsrC. This disulfide can be reduced by a number of proteins including DsrK and TcmB [5]. This enzyme is different from EC 1.8.1.2, assimilatory sulfite reductase (NADPH), and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin), which are involved in sulfate assimilation. " +"1.14.12.23","This enzyme is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms of a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It can typically act on many different nitroaromatic compounds, including chlorinated species. Enzymes found in different strains may have different substrate preferences. Requires Fe2+." +"1.14.13.204","The enzymes from solanaceous plants are involved in the biosynthesis of stigmatic estolide, a lipid-based polyester that forms a major component of the exudate." +"1.14.13.205","The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1). The plant enzyme CYP86A1 also acts on laurate (12:0). The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position. The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4)." +"1.14.18.4","The enzyme, characterized from the plant Ricinus communis (castor bean), is involved in production of the 12-hydroxylated fatty acid ricinoleate. The enzyme, which shares sequence similarity with fatty-acyl desaturases, requires a cytochrome b5 as the electron donor." +"1.14.18.5","The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase [4]." +"1.14.18.6","The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase." +"1.14.18.7","The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase. " +"1.14.19.11","The enzymes from the plants Coriandrum sativum (coriander) and Hedera helix (English ivy) are involved in biosynthesis of petroselinate [(6Z)-octadec-6-enoate], which is formed by elongation of (4Z)-hexadec-4-enoate. The ivy enzyme can also act on oleoyl-[acyl-carrier protein] and palmitoleoyl-[acyl-carrier protein], generating the corresponding 4,9-diene." +"1.14.19.12","The enzyme, characterized from the green alga Chlamydomonas reinhardtii, is a front-end desaturase that introduces a cis double bond in omega9 unsaturated C18 or C20 fatty acids incorporated into lipids, at a position 4 carbon atoms from the existing omega9 bond, towards the carboxy end of the fatty acid (at the omega13 position). When acting on 20:2Delta(11,14) and 20:3Delta(11,14,17) substrates it introduces the new double bond between carbons 7 and 8. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor for the active site of the desaturase. " +"1.14.19.13","The enzyme, characterized from the the plant Sorghum bicolor, is involved in the biosynthesis of sorgoleone, an allelopathic compound produced in root hair cells. The enzyme inserts a cis double bond at carbon 15. When acting on its natural substrate, (9Z,12Z)-hexadeca-9,12-dienoyl-CoA, it produces a product with a terminal double bond." +"1.14.19.14","The enzyme, characterized from the plant Calendula officinalis, converts a single cis double bond at position 9 of fatty acids incorporated into glycerolipids into two conjugated trans double bonds at positions 8 and 10." +"1.14.19.15","The enzyme, characterized from the silk moth Bombyx mori, catalyses a step in the pathway for the biosynthesis of bombykol, a sex pheromone produced by the moth. The enzyme converts a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds. Prior to catalysing this reaction, the enzyme catalyses the introduction of the cis bond in position 11 (cf. EC 1.14.19.5, acyl-CoA 11-desaturase)." +"1.14.19.16","The enzyme, characterized from the plants Punica granatum (pomegranate) and Trichosanthes kirilowii (Mongolian snake-gourd), converts a single cis double bond at position 12 of linoleate incorporated into phosphatidylcholine into conjugated 11-trans and 13-cis double bonds. cf. EC 1.14.19.33, Delta12 acyl-lipid conjugase (11E,13E-forming)." +"1.14.19.17","The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids [1]. The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide [2]. Unlike EC 1.14.19.29, sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain [4] and requires an external cytochrome b5 [3]. The product serves as an important signalling molecules in mammals and is required for spermatide differentiation [5]." +"1.14.19.18","The enzyme, characterized from the yeasts Kluyveromyces lactis and Candida albicans [1] and from the diatom Thalassiosira pseudonana [2], introduces a trans double bond at the 8-position of sphingoid bases in sphingolipids. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase [3]. The homologous enzymes from higher plants, EC 1.14.19.29, sphingolipid 8-(E/Z)-desaturase, act on phytosphinganine (4-hydroxysphinganine) and produces a mixture of trans and cis isomers." +"1.14.19.19","The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product. Similar triunsaturated sphingoid bases are found in some marine invertebrates. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase." +"1.14.19.20","This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Delta7-sterols, to yield the corresponding Delta5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound." +"1.14.19.21","The enzyme, characterized from several organisms including the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the ciliate Tetrahymena thermophila, is a Rieske oxygenase. In insects it participates in the the biosythesis of ecdysteroid hormones. The electrons are transferred from NAD(P)H via an electron transfer chain likely to include ferredoxin reductase and ferredoxin. The enzyme differs from regular desaturases, such as EC 1.14.19.20, 7-sterol 5(6)-desaturase, which are cytochrome b5-dependent and contain the three His-boxes that are typical to most desaturases." +"1.14.19.22","This microsomal enzyme introduces a cis double bond in fatty acids attached to lipid molecules at a location 6 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. The most common substrates are oleoyl groups attached to either the sn-1 or sn-2 position of the glycerol backbone in phosphatidylcholine. cf. EC 1.14.19.23, acyl-lipid omega-6 desaturase (ferredoxin)." +"1.14.19.23","This plastidial enzyme is able to insert a cis double bond in monounsaturated fatty acids incorporated into glycerolipids. The enzyme introduces the new bond at a position 3 carbons away from the existing double bond, towards the methyl end of the fatty acid. The native substrates are oleoyl (18:1 Delta9) and (Z)-hexadec-7-enoyl (16:1 Delta7) groups attached to either position of the glycerol backbone in glycerolipids, resulting in the introduction of the second double bond at positions 12 and 10, respectively This prompted the suggestion that this is an omega6 desaturase. However, when acting on palmitoleoyl groups(16:1 Delta9), the enzyme introduces the second double bond at position 12 (omega4), indicating it is an (n+3) desaturase [3]. cf. EC 1.14.19.34, acyl-lipid (9+3)-(E)-desaturase." +"1.14.19.24","Involved in sex pheromone synthesis in the Lepidoptera (moths). The enzyme from the moth Spodoptera littoralis prefers 13:0 and 14:0 substrates. The product is formed by the stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. cf. EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase." +"1.14.19.25","This microsomal enzyme introduces a cis double bond three carbons away from the methyl end of a fatty acid incorporated into a glycerolipid. The distance from the carboxylic acid end of the molecule does not have an effect. The plant enzyme acts on carbon 15 of linoleoyl groups incorporated into both the sn-1 and sn-2 positions of the glycerol backbone of phosphatidylcholine and other phospholipids, converting them into alpha-linolenoyl groups. The enzyme from the fungus Mortierella alpina acts on gamma-linolenoyl and arachidonoyl groups, converting them into stearidonoyl and icosapentaenoyl groups, respectively [3]. cf. EC 1.14.19.35, sn-2 acyl-lipid omega-3 desaturase (ferredoxin)." +"1.14.19.26","The enzyme, characterized from the endosperm of the plant Thunbergia alata (black-eyed Susan vine), introduces a cis double bond at carbon 6 of several saturated acyl-[acp]s. It is most active with palmitoyl-[acp] (16:0), but can also act on myristoyl-[acp] (14:0) and stearoyl-[acp] (18:0). The position of the double bond is determined by its distance from the carboxyl end of the fatty acid." +"1.14.19.27","The enzyme, characterized from the cyanobacterium Nostoc sp. 36, introduces a cis double bond at carbon 9 of palmitoyl groups (16:0) attached to the sn-2 position of glycerolipids." +"1.14.19.28","The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 9 of stearoyl groups (18:0) attached to the sn-1 position of glycerolipids. The enzyme is nonspecific with respect to the polar head group of the glycerolipid." +"1.14.19.29","The enzymes from higher plants convert sphinganine, 4E-sphing-4-enine and phytosphinganine into E/Z-mixtures of Delta8-desaturated products displaying different proportions of geometrical isomers depending on plant species. The nature of the actual desaturase substrate has not yet been studied experimentally. The enzymes contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase [1]. The homologous enzymes from some yeasts and diatoms, EC 1.14.19.18, sphingolipid 8-(E)-desaturase, act on sphing-4-enine ceramides and produce only the trans isomer." +"1.14.19.30","The enzyme, which has been characterized from multiple organisms including the moss Physcomitrella patens, the marine microalga Rebecca salina, and the filamentous fungus Mortierella alpina, introduces a cis double bond at the 5-position in 20-carbon polyunsaturated fatty acids incorporated in a glycerolipid that contain a Delta8 double bond. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome." +"1.14.19.31","The enzymes from several algae introduce a cis double bond at the 4-position in 22-carbon polyunsaturated fatty acids that contain a Delta7 double bond. The enzyme from the fresh water alga Chlamydomonas reinhardtii acts on the 16 carbon fatty acid (7Z,10Z,13Z)-hexadeca-7,10,13-trienoate [5]. The enzyme contains an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase, and does not require an external cytochrome." +"1.14.19.32","The enzyme, found in the moth Ostrinia furnacalis (Asian corn borer), produces a mixture of (E)- and (Z)- isomers. The products are subsequently truncated by partial beta-oxidation to a blend of 12(E/Z)-tetradec-12-enoyl-CoA, which are converted to the species-specific sex pheromones (E)- and (Z)-tetradec-12-enoyl acetates." +"1.14.19.33","The enzyme, characterized from the plants Impatiens balsamina, Momordica charantia (bitter gourd) and Vernicia fordii (tung tree), converts a single cis double bond at carbon 12 to two conjugated trans bonds at positions 11 and 13. The enzyme from Vernicia fordii can also act as a 12(E) desaturase when acting on the monounsaturated fatty acids oleate and palmitoleate. cf. EC 1.14.19.16, linoleoyl-lipid Delta12 conjugase (11E,13Z-forming)." +"1.14.19.34","The enzymes from the plants Dimorphotheca sinuata (African daisy) and Vernicia fordii (tung oil tree) insert a trans double bond in position C-12 of oleate and palmitoleate incorporated into glycerolipids. The enzyme introduces the new double bond at a position three carbons away from an existing double bond at position 9, towards the methyl end of the fatty acid. The enzyme from tung oil tree also possesses the activity of EC 1.14.19.33, Delta12 acyl-lipid conjugase." +"1.14.19.35","This plastidial enzyme desaturates 16:2 fatty acids attached to the sn-2 position of glycerolipids to 16:3 fatty acids, and converts18:2 to 18:3 in both the sn-1 and sn-2 positions. It acts on all 16:2- or 18:2-containing chloroplast membrane lipids, including phosphatidylglycerol, monogalactosyldiacylglycerol, digalactosyldiaclyglycerol, and sulfoquinovosyldiacylglycerol. The enzyme introduces a cis double bond at a location 3 carbons away from the methyl end of the fatty acid. The distance from the carboxylic acid end of the molecule does not affect the location of the new double bond. cf. EC 1.14.19.25, acyl-lipid omega-3 desaturase (cytochrome b5) and EC 1.14.19.36, sn-1 acyl-lipid omega-3 desaturase (ferredoxin)." +"1.14.19.36","The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 15 of linoleoyl and gamma-linolenoyl groups attached to the sn-1 position of glycerolipids. The enzyme is an omega desaturase, and determines the location of the double bond by counting three carbons from the methyl end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid. cf. EC 1.14.19.35, sn-2 acyl-lipid omega-3 desaturase (ferredoxin)." +"1.14.99.51","Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine." +"1.14.99.52","Requires Fe2+ for activity. The enzyme participates in ovothiol biosynthesis. It also has some activity as EC 1.13.11.20, cysteine dioxygenase, and can perform the reaction of EC 1.14.99.50, gamma-glutamyl hercynylcysteine sulfoxide synthase, albeit with low activity [4]." +"1.18.1.8","This iron-sulfur and flavin-containing electron transport complex, isolated from the bacterium Acetobacterium woodii, couples the energy from reduction of NAD+ by ferredoxin to pumping sodium ions out of the cell, generating a gradient across the cytoplasmic membrane. " +"1.21.1.1",The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN. +"1.21.1.2","The enzyme, characterized from Corynebacterium strains able to grow on 2,4-dichlorobenzoate, forms part of the 2,4-dichlorobenzoate degradation pathway." +"1.21.99.3","The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine. " +"2.1.1.316","The enzyme, characterized from the bacterium Streptomyces lavendulae, is involved in the biosynthesis of the quinone-containing antibiotics mitomycin A and mitomycin B." +"2.1.1.317","The enzyme, characterized from the fungi Komagataella pastoris and Fusarium graminearum, acts only on ceramides and has no activity with free sphingoid bases or glucosylceramides." +"2.1.1.318","The enzyme, characterized from the yeast Saccharomyces cerevisiae, enhances the activity of EC 2.4.1.15, trehalose-6-phosphate synthase, resulting in elevating the levels of trehalose in the cell and contributing to stationary phase survival. In vitro the enzyme performs S-methylation of L-cysteine residues of various protein substrates. " +"2.3.1.248","The enzyme from the plant Arabidopsis thaliana has no activity with 4-coumaroyl-CoA (cf. EC 2.3.1.249, spermidine dicoumaroyl transferase)." +"2.3.1.249","The enzyme from the plant Arabidopsis thaliana has no activity with sinapoyl-CoA (cf. EC 2.3.1.248, spermidine disinapoyl transferase)." +"2.3.1.250","The enzyme, found in animals, modifies a specific serine residue in Wnt proteins, e.g. Ser209 in human Wnt3a and Ser224 in chicken WNT1 [2,3]. The enzyme can accept C13 to C16 fatty acids in vitro, but only (9Z)-hexadecenoate modification is observed in vivo [1]. cf. EC 3.1.1.98, [Wnt protein]-O-palmitoleoyl-L-serine hydrolase." +"2.3.2.23",The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage. +"2.3.2.24","The enzyme transfers a single ubiquitin directly from an ubiquitinated E1 ubiquitin-activating enzyme to itself, and on to a lysine residue of the acceptor protein without involvement of E3 ubiquitin transferases (cf. EC 2.3.2.26, EC 2.3.2.27). It forms a labile ubiquitin adduct in the presence of E1, ubiquitin, and Mg2+-ATP and catalyses the conjugation of ubiquitin to protein substrates, independently of E3. This transfer has only been observed with small proteins. In vitro a transfer to small acceptors (e.g. L-lysine, N-acetyl-L-lysine methyl ester) has been observed [1]." +"2.3.2.25",The enzyme ubiquitinylates the N-terminus of the acceptor protein. It is not reactive towards free lysine. +"2.3.2.26","In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond. In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27, RING-type E3 ubiquitin transferase and EC 2.3.2.31, RBR-type E3 ubiquitin transferase." +"2.3.2.27","RING E3 ubiquitin transferases serve as mediators bringing the ubiquitin-charged E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) and an acceptor protein together to enable the direct transfer of ubiquitin through the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon-amino group of an L-lysine residue of the acceptor protein. Unlike EC 2.3.2.26, HECT-type E3 ubiquitin transferase, the RING-E3 domain does not form a catalytic thioester intermediate with ubiquitin. Many members of the RING-type E3 ubiquitin transferase family are not able to bind a substrate directly, and form a complex with a cullin scaffold protein and a substrate recognition module (the complexes are named CRL for Cullin-RING-Ligase). In these complexes, the RING-type E3 ubiquitin transferase provides an additional function, mediating the transfer of a NEDD8 protein from a dedicated E2 carrier to the cullin protein (see EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase). cf. EC 2.3.2.31, RBR-type E3 ubiquitin transferase." +"2.3.2.28","The enzyme, characterized from the bacterium Pseudomonas syringae, is involved in the biosynthesis of the toxin coronatine. " +"2.6.1.108"," A pyridoxal 5'-phosphate protein. The enzyme, characterized from the archaebacterium Methanocaldococcus jannaschii, participates in the biosynthesis of the cofactor methanofuran. Requires pyridoxal 5'-phosphate." +"2.6.1.109","The enzyme, characterized from the bacterium Shewanella oneidensis, forms 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate, an aminated form of Kdo found in lipopolysaccharides of members of the Shewanella genus. cf. EC 1.1.3.48, 3-deoxy-alpha-D-manno-octulosonate 8-oxidase." +"2.7.1.189",The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2. +"2.7.4.30","The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A." +"2.7.7.88","The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses and lyssaviruses) is specific for mRNAs with sequences starting with AACA. cf. EC 2.7.7.50, mRNA guanylyltransferase. " +"2.7.7.89","This bacterial enzyme removes an adenylyl group from a modified tyrosine residue of EC 6.3.1.2, glutamine synthetase. The enzyme is bifunctional, and also performs the adenylation of this residue (cf. EC 2.7.7.42, [glutamine synthetase] adenylyltransferase) [3,5]. The two activities are present on separate domains." +"2.7.8.42",The enzyme has been characterized from the bacterium Escherichia coli. It is activated by Ca2+ ions and is silenced by the sRNA MgrR. +"2.8.1.13","The enzyme, found in bacteria, catalyses formation of the 2-thiouridine modification in the wobble position of tRNAGln, tRNALys and tRNAGlu. " +"2.8.1.14","The enzyme, found in mitochondria, catalyses formation of 5-taurinomethyl-2-thiouridine in the wobble position of mitochondrial tRNAGln, tRNALys and tRNAGlu. " +"2.8.3.23","The enzyme, isolated from the bacterium Acetobacterium woodii, catalyses an energy-saving CoA loop for caffeate activation. In addition to caffeate, the enzyme can utilize 4-coumarate or ferulate as CoA acceptor. " +"3.1.1.98","The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase." +"3.4.24.88","The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolysing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. The enzyme contains Zn2+. cf. EC 3.4.19.12, ubiquitinyl hydrolase 1. In peptidase family M67. " +"3.4.24.89","This metalloprotease, which is secreted by the bacterium Peptoclostridium difficile, contains zinc." +"4.1.1.101","The enzyme is involved in the malolactic fermentation of wine, which results in a natural decrease in acidity and favorable changes in wine flavors. It has been purified from several lactic acid bacteria, including Leuconostoc mesenteroides [1], Lactobacillus plantarum [2], and Oenococcus oeni [3,4]. The enzyme contains a tightly bound NAD+ cofactor and requires Mn2+." +"4.2.1.156","Requires Mg2+. The enzyme, isolated from the bacteria Salmonella typhimurium and Polaromonas sp. JS666, also has activity with galactarate (cf. EC 4.2.1.42, galactarate dehydratase)." +"4.2.1.157","The enzyme, isolated from the bacterium Peptoclostridium difficile, is involved in the reductive branch of L-leucine fermentation. It catalyses an alpha/beta-dehydration, which depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI. " +"4.2.1.158","The enzyme has been characterized from the bacterium Oceanobacillus iheyensis. cf. EC 4.2.1.42, galactarate dehydratase." +"5.1.1.21","A pyridoxal phosphate protein. The enzyme, characterized from the bacterium Lactobacillus buchneri, specifically catalyses racemization of nonpolar amino acids at the C-2 position." +"5.1.3.33","The enzyme, characterized from the bacterium Actinomyces sp. Lu 9419, is involved in the biosynthesis of the antitumor agent cetoniacytone A. " +"5.1.3.34","The enzyme, characterized from cyanobacteria, is involves in the biosynthesis of galactolipids found in their photosynthetic membranes." +"5.1.3.35","The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose." +"5.1.99.7","The enzyme, found in gammaproteobacteria, has almost no activity with 7,8-dihydroneopterin [2]." +"5.3.3.19","The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme can interconvert the (E) isomer formed in the reaction into the (Z) isomer [2], although this isomerization is not part of the pathway leading to bacilysin [3]." +"5.4.1.4","The enzyme, characterized from the bacterium Agrobacterium fabrum strain C58, belongs to the amidohydrolase superfamily. It participates in the degradation of D-galacturonate." +"5.4.99.63","The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires adenosylcobalamin for activity." +"5.5.1.27","The enzyme, characterized from the bacterium Agrobacterium fabrum strain C58, is involved in degradation of D-galacturonate and D-glucuronate. Activity with D-galactaro-1,4-lactone is 4-fold higher than with D-glucaro-1,4-lactone." +"6.2.1.45","Catalyses the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein. The two-step reaction consists of the ATP-dependent formation of an E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step." +"6.2.1.46","This two-domain protein from the bacterium Pseudomonas syringae contains an adenylation domain (A domain) and a thiolation domain (T domain). It catalyses the adenylation of L-allo-isoleucine and its attachment to the T domain. The enzyme is involved in the biosynthesis of the toxin coronatine, which mimics the plant hormone jasmonic acid isoleucine. Coronatine promotes opening of the plant stomata allowing bacterial invasion, which is followed by bacterial growth in the apoplast, systemic susceptibility, and disease." +"6.3.2.48","The enzyme, characterized from the bacterium Bacillus subtilis, requires Mn2+ for activity. It shows strict substrate specificity toward L-arginine as the first (N-terminal) amino acid of the product. The second amino acid could be any standard protein-building amino acid except for L-proline. " +"6.3.2.49","The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme requires Mg2+ or Mn2+ for activity, and has a broad substrate specificity in vitro [1]." +"1.1.1.389","The enzyme, characterized from agarose-degrading bacteria, is involved in a degradation pathway for 3,6-anhydro-alpha-L-galactopyranose, a major component of the polysaccharides of red macroalgae." +"1.1.1.390","The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway. Activity with NADP+ is only 4% of that with NAD+." +"1.2.1.96","Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+)." +"1.2.1.97","The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway. Also acts on succinate semialdehyde." +"1.3.1.108","The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA." +"1.3.1.109","The enzyme is a complex of a flavin-containing dehydrogenase component (Bcd) and an electron-transfer flavoprotein dimer (EtfAB). The enzyme complex, isolated from the bacteria Acidaminococcus fermentans and butanoate-producing Clostridia species, couples the exergonic reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA by NADH to the endergonic reduction of ferredoxin by NADH, using electron bifurcation to overcome the steep energy barrier in ferredoxin reduction." +"1.3.1.110","The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+. " +"1.6.1.5",The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. +"1.6.5.12","The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor." +"1.13.11.81","The enzyme from the bacterium Mycobacterium tuberculosis is multifunctional and also catalyses the epimerisation of the 2'-hydroxy group of 7,8-dihydroneopterin (EC 5.1.99.8, 7,8-dihydroneopterin epimerase) and the reaction of EC 4.1.2.25 (dihydroneopterin aldolase)." +"1.13.11.82",Isolated from the bacterium Novosphingobium aromaticivorans. It is less active with 4'-apo-beta-carotenal and gamma-carotene. +"1.14.11.49","The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+." +"1.14.12.24","This enzyme, characterized from the bacterium Burkholderia sp. strain DNT, is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It does not act on nitrobenzene. cf. EC 1.14.12.23, nitroarene dioxygenase." +"1.14.13.206","This plant enzyme is involved in the synthesis of sporopollenin - a complex polymer found at the outer layer of spores and pollen. It can also act on decanoate (C10), myristate (C14), and palmitate (C16) with lower activity. The enzyme also produces a small amount of products that are hydroxylated at neighboring positions (C-6, C-8 and C-9)." +"1.14.13.207","A cytochrome P-450 heme-thiolate protein. Involved in the insect aggregation pheromone production. Isolated from the pine engraver beetle, Ips pini. A small amount of (S)-ipsdienol is also formed. In vitro it also hydroxylated (+)- and (-)-alpha-pinene, 3-carene, and (+)-limonene, but not alpha-phellandrene, (-)-beta-pinene, gamma-terpinene, or terpinolene." +"1.14.13.208","The enzyme is involved in aerobic benzoate metabolism in Azoarcus evansii. BoxB functions as the oxygenase part of benzoyl-CoA oxygenase in conjunction with BoxA, the reductase component, which upon binding of benzoyl-CoA, transfers two electrons to the ring in the course of monooxygenation. BoxA is a homodimeric 46 kDa iron-sulfur-flavoprotein (FAD), BoxB is a monomeric iron-protein [1]." +"1.14.13.209","The enzyme, characterized from the bacterium Streptomyces sp. WA46, participates in a pathway for salicylate degradation. cf. EC 1.14.13.172, salicylate 5-hydroxylase." +"1.14.14.16","A P-450 heme-thiolate protein responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase." +"1.14.14.17","A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7, lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH---hemoprotein reductase [5,7]." +"1.14.14.18","This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The enzyme requires NAD(P)H and EC 1.6.2.4, NADPH---hemoprotein reductase. cf. EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin)." +"1.14.14.19","Requires NADPH and EC 1.6.2.4, NADPH---hemoprotein reductase. A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17alpha-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis, and the conversion of the 17alpha-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis (EC 1.14.14.32, 17alpha-hydroxyprogesterone deacetylase). The ratio of the 17alpha-hydroxylase and 17,20-lyase activities is an important factor in determining the directions of steroid hormone biosynthesis towards biosynthesis of glucocorticoid or sex hormones." +"1.14.15.14","The enzyme, found in pathogenic and nonpathogenic mycobacteria species, actinomycetes, and some proteobacteria, hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. It is a P-450 heme-thiolate enzyme." +"1.14.18.8","A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH---hemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid [2]." +"1.14.19.37","The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC 1.14.19.44, acyl-CoA (8-3)-desaturase." +"1.14.19.38","The enzyme, characterized from the moss Ceratodon purpureus, converts the double bond at position 6 of gamma-linolenate and stearidonate into a triple bond. The product of the latter, dicranin, is the main fatty acid found in C. purpureus. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The enzyme also has the activity of EC 1.14.19.47, acyl-lipid (9-3)-desaturase." +"1.14.19.39","The enzyme, characterized from the plant Crepis alpina, converts the double bond at position 12 of linoleate into a triple bond. The product is the main fatty acid found in triacylglycerols in the seed oil of Crepis alpina." +"1.14.19.40","The enzyme, characterized from the marine cyanobacterium Moorea producens, is involved in production of the ion channel blocker jamaicamide A. It is specific for hexanoate or hex-5-enoate loaded onto a dedicated acyl-carrier protein (JamC), which is encoded by a gene in the same operon." +"1.14.19.41","A heme-thiolate protein (P-450). The enzyme, found in yeast and plants, catalyses the introduction of a double bond between the C-22 and C-23 carbons of certain sterols. In yeast the enzyme acts on ergosta-5,7,24(28)-trien-3beta-ol, a step in the biosynthesis of ergosterol. The enzyme from the plant Arabidopsis thaliana acts on sitosterol and 24-epi-campesterol, producing stigmasterol and brassicasterol, respectively." +"1.14.19.42",The enzyme introduces a cis double bond at carbon 7 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in monogalactosyldiacylglycerol. +"1.14.19.43",The enzyme introduces an unusual trans double bond at carbon 3 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in phosphatidylglycerol. The enzyme from tobacco can also accept oleate and alpha-linolenate if present at the sn-2 position of phosphatidylglycerol [1]. +"1.14.19.44","The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8. The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyse the desaturation of dihomo-gamma-linoleate [(8Z,11Z,14Z)-icosa-8,11,14-trienoate] and (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome. cf. EC 1.14.19.37, acyl-CoA 5-desaturase." +"1.14.19.45","The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 12 of oleoyl groups (18:1) attached to the sn-1 position of glycerolipids. The enzyme is a methyl-end desaturase, introducing the new double bond between a pre-existing double bond and the methyl-end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid." +"1.14.19.46","The enzyme, characterized from cyanobacteria, introduces a cis double bond at carbon 6 of linoleoyl groups (18:2) attached to the sn-1 position of glycerolipids. The enzyme is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. It is nonspecific with respect to the polar head group of the glycerolipid." +"1.14.19.47","The enzyme, characterized from the moss Physcomitrella patens and the plant Borago officinalis (borage), introduces a cis double bond at carbon 6 of several acyl-lipids that contain an existing Delta9 cis double bond. The enzyme contains a cytochrome b5 domain that acts as the electron donor for the active site of the desaturase." +"1.21.99.4","The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide." +"2.1.1.319","This eukaryotic enzyme catalyses the sequential dimethylation of one of the terminal guanidino nitrogen atoms in arginine residues, resulting in formation of asymmetric dimethylarginine residues. Some forms (e.g. PRMT1) have a very wide substrate specificity, while others (e.g. PRMT4 and PRMT6) are rather specific. The enzyme has a preference for methylating arginine residues that are flanked by one or more glycine residues [1]. PRMT1 is responsible for the bulk (about 85%) of total protein arginine methylation activity in mammalian cells [2]. cf. EC 2.1.1.320, type II protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase." +"2.1.1.320","The enzyme catalyses the methylation of one of the terminal guanidino nitrogen atoms in arginine residues within proteins, forming monomethylarginine, followed by the methylation of the second terminal nitrogen atom to form a symmetrical dimethylarginine. The mammalian enzyme is active in both the nucleus and the cytoplasm, and plays a role in the assembly of snRNP core particles by methylating certain small nuclear ribonucleoproteins. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase." +"2.1.1.321","Type III protein arginine methyltransferases catalyse the single methylation of one of the terminal nitrogen atoms of the guanidino group in an L-arginine residue within a protein. Unlike type I and type II protein arginine methyltransferases, which also catalyse this reaction, type III enzymes do not methylate the substrate any further. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, and EC 2.1.1.322, type IV protein arginine methyltransferase." +"2.1.1.322","This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, and EC 2.1.1.321, type III protein arginine methyltransferase." +"2.3.1.251",Isolated from the bacteria Escherichia coli and Salmonella typhimurium. The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position. There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds. The enzyme also acts on Kdo-(2->4)-Kdo-(2->6)-lipid IVA. +"2.4.1.335","The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain. " +"2.4.1.336","The enzymes from cyanobacteria are involved in the biosynthesis of galactolipids found in their photosynthetic membranes. The enzyme belongs to the GT2 family of configuration-inverting glycosyltranferases [2]. cf. EC 2.4.1.337, 1,2-diacylglycerol 3-alpha-glucosyltransferase." +"2.4.1.337","The enzyme from the bacterium Acholeplasma laidlawii, which lacks a cell wall, produces the major non-bilayer lipid in the organism. The enzyme from the bacterium Agrobacterium tumefaciens acts under phosphate deprivation, generating glycolipids as surrogates for phospholipids. The enzyme belongs to the GT4 family of configuration-retaining glycosyltransferases. Many diacylglycerols with long-chain acyl groups can act as acceptors. cf. EC 2.4.1.336, monoglucosyldiacylglycerol synthase." +"2.4.99.21","The enzyme, characterized from the archaea Methanococcus voltae and Haloferax volcanii, transfers a glycan component from dolichyl phosphooligosaccharide to external proteins. It is different from EC 2.4.99.18, dolichyl-diphosphooligosaccharide-protein glycotransferase, which uses dolichyl diphosphate as carrier compound in bacteria and eukaryotes. The enzyme participates in the N-glycosylation of proteins in some archaea. It requires Mn2+. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain. " +"2.5.1.129","The enzyme produces the modified flavin cofactor prenylated FMNH2, which is required by EC 4.1.1.98, 4-hydroxy-3-polyprenylbenzoate decarboxylase, and EC 4.1.1.102, phenacrylate decarboxylase. The enzyme acts as a flavin prenyltransferase, linking a prenyl moiety to the flavin N-5 and C-6 atoms and thus adding a fourth non-aromatic ring to the flavin isoalloxazine group." +"2.5.1.130","This enzyme, found in plants and cyanobacteria, catalyses a step in the synthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme catalyses the transfer of the phytyl chain synthesized by EC 1.3.1.83, geranylgeranyl diphosphate reductase, to 2-carboxy-1,4-naphthoquinone." +"2.5.1.131","The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, participates in the biosynthesis of the methanofuran cofactor." +"2.7.1.190","Requires Mg2+. This bacterial enzyme phosphorylates many 4,6-disubstituted aminoglycoside antibiotics that have a hydroxyl group at position 2'', including kanamycin A, kanamycin B, tobramycin, dibekacin, arbekacin, amikacin, gentamicin C, sisomicin and netilmicin. In most, but not all, cases the phosphorylation confers resistance against the antibiotic. Some forms of the enzyme use ATP as a phosphate donor in appreciable amount. The enzyme is often found as a bifunctional enzyme that also catalyses 6'-aminoglycoside N-acetyltransferase activity. The bifunctional enzyme is the most clinically important aminoglycoside-modifying enzyme in Gram-positive bacteria, responsible for high-level resistance in both Enterococci and Staphylococci." +"2.7.4.31","Requires Mg2+. The enzyme, isolated from the archaeon Methanocaldococcus jannaschii, participates in the biosynthesis of the methanofuran cofactor." +"3.1.3.98","The enzyme, characterized from roses, is involved in a cytosolic pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance. In vitro the enzyme also acts on (2E,6E)-farnesyl diphosphate." +"3.5.1.119","The enzyme has been characterized from the bacterium Mycobacterium tuberculosis. It catalyses the hydrolysis of the amido group of the C-terminal glutamine of prokaryotic ubiquitin-like protein (Pup), thus activating it for ligation to target proteins, a process catalysed by EC 6.3.1.19, prokaryotic ubiquitin-like protein ligase. The reaction requires ATP as cofactor but not its hydrolysis. The enzyme also catalyses the hydrolytic cleavage of the bond formed by the ligase, between an epsilon-amino group of a lysine residue of the target protein and the gamma-carboxylate of the C-terminal glutamate of the prokaryotic ubiquitin-like protein. " +"4.1.1.102","The enzyme, found in fungi, catalyses the decarboxylation of phenacrylic acids present in plant cell walls. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase." +"4.2.1.159","The enzyme participates in the biosynthesis of several deoxysugars, including beta-L-4-epi-vancosamine, alpha-L-megosamine, L- and D-olivose, D-oliose, D-mycarose, forosamine and beta-L-digitoxose. In vitro the intermediate can undergo a spontaneous decomposition to maltol [2,3]." +"4.2.1.160",The enzyme participates in a folate biosynthesis pathway in Chlamydia. +"4.2.1.161","The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the introduction of hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin to generate bacterioruberin." +"4.2.2.26","The enzyme degrades unsaturated oligosaccharides produced by the action of alginate lyases (EC 4.2.2.3 and EC 4.2.2.11) on alginate, by repeatedly removing the unsaturated residue from the non-reducing end until only unsaturated monosaccharides are left. The enzyme catalyses a beta-elimination reaction, generating a new unsaturated non-reducing end after removal of the pre-existing one." +"4.2.3.153","The enzyme catalyses the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran. The sequence of events starts with the removal of a phosphate group, followed by aldol condensation and cyclization. Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea." +"5.1.3.36","The enzyme, characterized from the giant African snail Achatina fulica, participates in the biosynthetic pathway of acharan sulfate. Unlike EC 5.1.3.17, heparosan-N-sulfate-glucuronate 5-epimerase, it shows no activity with D-glucuronate residues in heparosan-N-sulfate." +"5.1.3.37","The enzyme epimerizes the C-5 bond in some beta-D-mannuronate residues in mannuronan, converting them to alpha-L-guluronate residues, and thus modifying the mannuronan into alginate. It is found in brown algae and alginate-producing bacterial species from the Pseudomonas and Azotobacter genera." +"5.1.99.8","The enzyme, which has been characterized in bacteria and plants, also has the activity of EC 4.1.2.25, dihydroneopterin aldolase. The enzyme from the bacterium Mycobacterium tuberculosis has an additional oxygenase function (EC 1.13.11.81, 7,8-dihydroneopterin oxygenase) [4]." +"6.3.1.19","The enzyme has been characterized from the bacteria Mycobacterium tuberculosis and Corynebacterium glutamicum. It catalyses the ligation of the prokaryotic ubiquitin-like protein (Pup) to a target protein by forming a bond between an epsilon-amino group of a lysine residue of the target protein and the gamma-carboxylate of the C-terminal glutamate of the ubiquitin-like protein (Pup). The attachment of Pup, also known as Pupylation, marks proteins for proteasomal degradation." +"1.1.1.391","This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.393, 3beta-hydroxycholanate 3-dehydrogenase (NADP+)." +"1.1.1.392","This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+)." +"1.1.1.393","This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3beta-hydroxycholanate 3-dehydrogenase (NAD+)." +"1.1.1.394","The enzyme from the bacterium Stigmatella aurantiaca catalyses the final step in the conversion of aurachin C to aurachin B. In vivo the enzyme catalyses the reduction of 4-[(2E,6E)-farnesyl]-4-hydroxy-2-methyl-3-oxo-3,4-dihydroquinoline-1-oxide to form 4-[(2E,6E)-farnesyl]-2-methyl-1-oxo-3,4-dihydroquinoline-3,4-diol (note that the reactions written above proceed from right to left), which then undergoes a spontaneous dehydration to form aurachin B." +"1.2.5.3","This enzyme, found in carboxydotrophic bacteria, catalyses the oxidation of CO to CO2 under aerobic conditions. The enzyme contains a binuclear Mo-Cu cluster in which the copper is ligated to a molybdopterin center via a sulfur bridge. The enzyme also contains two [2Fe-2S] clusters and FAD, and belongs to the xanthine oxidoreductase family. The CO2 that is produced is assimilated by the Calvin-Benson-Basham cycle, while the electrons are transferred to a quinone via the FAD site, and continue through the electron transfer chain to a dioxygen terminal acceptor [5]. cf. EC 1.2.7.4, anaerobic carbon monoxide dehydrogenase." +"1.3.1.111","The enzyme catalyses the successive reduction of the geranylgeraniol esterifying group to phytol, reducing three out of four double bonds, and transforming geranylgeranyl bacteriochlorophyllide a via dihydrogeranylgeranyl bacteriochlorophyllide a and tetrahydrogeranylgeranyl bacteriochlorophyllide a to bacteriochlorophyll a. The enzyme can also accept the pheophytin derivative geranylgeranyl bacteriopheophytin, converting it to bacteriopheophytin a." +"1.3.7.12","The enzyme participates in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The reaction requires reduced ferredoxin, which is generated from NADPH produced either through the pentose-phosphate pathway or by the action of photosystem I [1,2]. This reaction takes place while red chlorophyll catabolite is still bound to EC 1.14.15.17, pheophorbide a oxygenase [3]. Depending on the plant species used as the source of enzyme, one of two possible C-1 epimers of primary fluorescent chlorophyll catabolite (pFCC), pFCC-1 or pFCC-2, is normally formed, with all genera or species within a family producing the same isomer [3,4]. After modification and export, pFCCs are eventually imported into the vacuole, where the acidic environment causes their non-enzymic conversion into colourless breakdown products called non-fluorescent chlorophyll catabolites (NCCs) [2]." +"1.14.11.50","The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold." +"1.14.13.210","Contains FAD. The enzyme, isolated from the bacterium Burkholderia sp. DNT, can use both NADH and NADPH, but prefers NADPH. It has a narrow substrate range, but can also act on 4-nitrocatechol." +"1.14.13.211","The enzyme has been found in a variety of environmental bacteria, notably Rhodococcus, Nocardia, and Streptomyces. It hydroxylates C-2 of rifampicin leading to its macro-ring cleaving." +"1.14.13.212","The enzyme, characterized from the bacterium Pseudomonas sp. CBB1, is part of the bacterial C-8 oxidation-based caffeine degradation pathway. The product decomposes spontaneously to a racemic mixture of 3,6,8-trimethylallantoin. The enzyme shows no acitivity with urate. cf. EC 1.14.13.113, FAD-dependent urate hydroxylase." +"1.14.13.213","This cytochrome P-450 enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs." +"1.14.13.214","This cytochrome P-450 enzyme, characterized from the plant Sinopodophyllum hexandrum, produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency." +"1.14.13.215","The enzyme, characterized from the bacterium Streptomyces nodosus subsp. asukaensis, is involved in the biosynthesis of the antibiotic asukamycin. Requires a flavin cofactor, with no preference among FMN, FAD or riboflavin. When flavin concentration is low, activity is enhanced by the presence of the NADH-dependent flavin-reductase AsuE2." +"1.14.13.216","The enzyme, characterized from the fungus Aspergillus alliaceus, contains an FAD cofactor. The enzyme inserts a hydroxyl group, leading to formation of a N-C bond that creates an additional cycle between the bicyclic indole and the tetracyclic core moieties, resulting in the heptacyclic asperlicin E." +"1.14.13.217","The enzyme, characterized from the bacterium Chromobacterium violaceum, participates in the biosynthesis of the violet pigment violacein. The product, protoviolaceinate, can be acted upon by EC 1.14.13.224, violacein synthase, leading to violacein production. However, it is very labile, and in the presence of oxygen can undergo non-enzymic autooxidation to the shunt product proviolacein." +"1.14.14.20","The enzyme catalyses the ortho-hydroxylation of simple phenols into the corresponding catechols. It accepts 4-methylphenol, 4-chlorophenol, and 4-fluorophenol [1] as well as 4-nitrophenol, 3-nitrophenol, and resorcinol [3]. The enzyme is part of a two-component system that also includes an NADH-dependent flavin reductase. It is strictly dependent on FADH2 and does not accept FMNH2 [1,3]. cf. EC 1.14.13.7, phenol 2-monooxygenase (NADPH)." +"1.14.14.21","This bacterial enzyme catalyses the first two steps in the desulfurization pathway of dibenzothiophenes, the oxidation of dibenzothiophene into dibenzothiophene sulfone via dibenzothiophene-5-oxide. The enzyme forms a two-component system with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42) encoded by the dszD gene, which also interacts with EC 1.14.14.22, dibenzothiophene sulfone monooxygenase." +"1.14.14.22","This bacterial enzyme catalyses a step in the desulfurization pathway of dibenzothiophenes. The enzyme forms a two-component system with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42) encoded by the dszD gene, which also interacts with EC 1.14.14.21, dibenzothiophene monooxygenase. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule." +"1.14.14.23","A P-450 heme-thiolate liver protein that catalyses the first step in the biosynthesis of bile acids. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase." +"1.14.14.24","A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase." +"1.14.14.25","A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood---brain barrier whereas cholesterol cannot [3]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase [3]." +"1.14.14.26","A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase." +"1.14.15.15","This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-ene-3beta,7alpha-diol, 7alpha-hydroxycholest-4-en-3-one, and 5beta-cholestane-3alpha,7alpha-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase." +"1.14.15.16","This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase." +"1.14.15.17","This enzyme catalyses a key reaction in chlorophyll degradation, which occurs during leaf senescence and fruit ripening in higher plants. The enzyme from Arabidopsis contains a Rieske-type iron-sulfur cluster [2] and requires reduced ferredoxin, which is generated either by NADPH through the pentose-phosphate pathway or by the action of photosystem I [4]. While still attached to this enzyme, the product is rapidly converted into primary fluorescent chlorophyll catabolite by the action of EC 1.3.7.12, red chlorophyll catabolite reductase [2,6]. Pheophorbide b acts as an inhibitor. In 18O2 labelling experiments, only the aldehyde oxygen is labelled, suggesting that the other oxygen atom may originate from H2O [1]." +"1.14.21.11","The enzyme, characterized from the plants Sinopodophyllum hexandrum and Podophyllum peltatum, catalyses the formation of a methylenedioxy-bridge. It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs." +"1.17.7.4","An iron-sulfur protein that contains an unusual [4Fe-4S] cluster [5,6]. This enzyme forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of 3-methylbut-3-en-1-yl diphosphate and prenyl diphosphate." +"1.21.98.2","This enzyme catalyses a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is a dimeric heme-protein oxidase that catalyses the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin [1]. Contains one molecule of heme b per monomer, as well as non-heme iron that is not part of an iron-sulfur center [2]. In vivo the enzyme uses hydrogen peroxide, formed by the enzyme upstream in the biosynthetic pathway (EC 1.4.3.23, 7-chloro-L-tryptophan oxidase) as the electron acceptor. However, the enzyme is also able to catalyse the reaction using molecular oxygen [3]." +"2.1.1.323","The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs." +"2.1.1.324","The enzyme was isolated from the bacterium Saccharopolyspora spinosa, where it is involved in the biosynthesis of spinosyn A, an active ingredient of several commercial insecticides." +"2.6.1.110","A pyridoxal-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine." +"2.7.1.191","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.192","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.193","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.194","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.195","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.196","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.197","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.198","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.199","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.200","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.201","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.202","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is usually a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). The enzyme from the bacterium Escherichia coli is an exception, since it is phosphorylated directly by EC 2.7.3.9. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.203","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.204","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.205","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.206","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.207","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.208","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"3.1.1.99","The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway." +"3.1.3.99","The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+." +"3.1.3.100","The enzyme participates in the thiamine biosynthesis pathway in eukaryotes and a few prokaryotes. These organisms lack EC 2.7.4.16, thiamine-phosphate kinase, and need to convert thiamine phosphate to thiamine diphosphate, the active form of the vitamin, by first removing the phosphate group, followed by diphosphorylation by EC 2.7.6.2, thiamine diphosphokinase." +"3.2.1.196","This bacterial enzyme catalyses a reaction similar to EC 3.2.1.33, amylo-alpha-1,6-glucosidase (one of the activities of the eukaryotic glycogen debranching enzyme). However, while EC 3.2.1.33 removes single glucose residues linked by 1,6-alpha-linkage, and thus requires the additional activity of 4-alpha-glucanotransferase (EC 2.4.1.25) to act on limit dextrins formed by glycogen phosphorylase (EC 2.4.1.1), this enzyme removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin without a need for another enzyme." +"3.7.1.23","The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC 3.7.1.5, acylpyruvate hydrolase." +"3.9.1.3","This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- and tele-nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) [4]. The substrate specificity depends on the amino acid sequence or structural context of the phosphohistidine in a phosphoprotein. The enzyme is also active on free phosphoramidate [1,4] and peptide-bound phospholysine [5]." +"4.1.2.58","The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway." +"4.2.1.162","The enzyme, characterized from the bacterium Pseudomonas putida SQ1, participates in a sulfoquinovose degradation pathway." +"4.2.1.163",Requires Mg2+ [2]. Part of a 4-hydroxyphenylacetate degradation pathway in Escherichia coli C. +"4.2.99.23","The enzyme, characterized from pollen of the plant Tulipa gesneriana (tulip), catalyses the intramolecular transesterification of 6-tuliposide B to form the antibiotic aglycon tulipalin B as a sole product. It does not catalyse the hydrolysis of 6-tuliposide B to form a hydroxy acid. The enzyme has marginal activity with 6-tuliposide A. cf. EC 4.2.99.22, tuliposide A-converting enzyme." +"6.3.1.20"," Requires Mg2+. This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid [7]. The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [6]. Lipoylation is essential for the function of these enzymes. The enzyme can also use octanoate instead of lipoate." +"1.1.1.395","This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation. The enzyme has very little activity with unconjugated bile acid substrates. It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA." +"1.1.1.396","The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group." +"1.1.1.397","The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2)." +"1.1.1.398","The enzyme, characterized from the bacterium Rhodococcus sp. AD45, is involved in isoprene degradation." +"1.1.1.399","The enzyme catalyses a reversible reaction. The enzyme from the bacterium Peptoniphilus asaccharolyticus is specific for (R)-2-hydroxyglutarate [1,2]. The SerA enzyme from the bacterium Escherichia coli can also accept (S)-2-hydroxyglutarate with a much higher Km, and also catalyses the activity of EC 1.1.1.95, phosphoglycerate dehydrogenase [3]." +"1.1.1.400","This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant." +"1.1.1.401","The enzyme, characterized from the bacteria Sphingomonas sp. SKA58 and Sulfobacillus thermosulfidooxidans, is involved in the non-phosphorylative degradation pathway for L-rhamnose. It does not show any detectable activity with NADP+ or with other aldoses." +"1.1.1.402","The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism." +"1.1.1.403","The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of D-threitol." +"1.1.2.9","This periplasmic quinoprotein alcohol dehydrogenase, characterized from the bacterium Thauera butanivorans, is involved in butane degradation. It contains both pyrroloquinoline quinone (PQQ) and heme c cofactors. cf. EC 1.1.5.11, 1-butanol dehydrogenase (quinone)." +"1.1.5.11","This periplasmic quinoprotein alcohol dehydrogenase, characterized from the bacterium Thauera butanivorans, is involved in butane degradation. It contains a tightly-bound pyrroloquinoline quinone (PQQ) cofactor. cf. EC 1.1.2.9, 1-butanol dehydrogenase (cytochrome c)." +"1.2.1.98","This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant." +"1.2.3.15","The enzyme, originally characterized from the white rot fungus Phanerochaete chrysosporium, utilizes a free radical-coupled copper complex for catalysis." +"1.3.3.15","Contains FAD. The enzyme, present in Gram-positive bacteria, participates in heme biosynthesis. It can also catalyse the reaction of EC 1.3.3.4, protoporphyrinogen oxidase, at a lower level." +"1.3.7.13","The enzyme, found in many phototrophic bacteria, land plants, and some green and red algae, is involved in the production of monovinyl versions of (bacterio)chlorophyll pigments from their divinyl precursors. Binds two [4Fe-4S] clusters and an FAD cofactor. It can also act on 3,8-divinyl chlorophyllide a, 3,8-divinyl chlorophyll a, and chlorophyll c2. cf. EC 1.3.1.75, 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)." +"1.3.7.14","The enzyme, found only in bacteriochlorophyll b-producing bacteria, catalyses the introduction of a C-8 ethylidene group. The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of nitrogenase. It is very similar to EC 1.3.7.15, chlorophyllide a reductase, and is composed of three subunits. Two of them form the catalytic component, while the third one functions as an ATP-dependent reductase component that catalyses the electron transfer from ferredoxin to the catalytic component." +"1.3.7.15","The enzyme, together with EC 1.1.1.396, bacteriochlorophyllide-a dehydrogenase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. These enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. This enzyme catalyses a trans-reduction of the B-ring; the product has the (7R,8R)-configuration. In addition, the enzyme has a latent activity of EC 1.3.7.13, 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin) [4]. The enzyme contains a [4Fe-4S] cluster, and structurally resembles the Fe protein/MoFe protein complex of nitrogenase (EC 1.18.6.1), which catalyses an ATP-driven reduction. " +"1.3.98.3","This enzyme differs from EC 1.3.3.3, coproporphyrinogen oxidase, by using S-adenosyl-L-methionine (AdoMet) instead of oxygen as oxidant. It occurs mainly in bacteria, whereas eukaryotes use the oxygen-dependent oxidase. The reaction starts by using an electron from the reduced form of the enzyme's [4Fe-4S] cluster to split AdoMet into methionine and the radical 5'-deoxyadenosin-5'-yl. This radical initiates attack on the 2-carboxyethyl groups, leading to their conversion into vinyl groups. This conversion, ---(.)CH-CH2-COO- -> ---CH=CH2 + CO2 + e- replaces the electron initially used." +"1.7.2.7","The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only a few enzymes that are known to form an N-N bond (other examples include EC 1.7.1.14, nitric oxide reductase [NAD(P)+, nitrous oxide-forming] and EC 4.8.1.1, L-piperazate synthase). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is a dimer of heterotrimers and contains multiple c-type cytochromes." +"1.7.2.8","The enzyme, which is involved in the pathway of anaerobic ammonium oxidation in anammox bacteria, has been purified from the bacterium Candidatus Kuenenia stuttgartiensis. The electrons derived from hydrazine are eventually transferred to the quinone pool." +"1.14.11.51","Contains iron(II). Catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons, which are specifically enriched on the human X chromosome." +"1.14.11.52",The enzyme was characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus. Requires Fe2+. +"1.14.11.53","Contains iron(II). Catalyses oxidative demethylation of mRNA N6-methyladenine. The FTO enzyme from human can also demethylate N3-methylthymine from single stranded DNA and N3-methyluridine from single stranded RNA [1,2] with low activity [3]." +"1.14.13.218","The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. It can also act on phenazine-1-carboxylate, converting it into phenazin-1-ol." +"1.14.13.219","The enzyme, characterized from the bacterium Corynebacterium glutamicum, is a single-component hydroxylase. The enzyme has no activity with NADH. cf. EC 1.14.13.220, resorcinol 4-hydroxylase (NADH), and EC 1.14.14.27, resorcinol 4-hydroxylase (FADH2)." +"1.14.13.220","The enzyme, characterized from the bacterium Rhodococcus jostii RHA1, is a single-component hydroxylase. The enzyme has no activity with NADPH. cf. EC 1.14.13.219, resorcinol 4-hydroxylase (NADPH), and EC 1.14.14.27, resorcinol 4-hydroxylase (FADH2)." +"1.14.13.221","This enzyme, found in several bacterial pathogens, is involved in degradation of the host cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol. The products are exclusively in the (25R) conformation. The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.13.141, cholest-4-en-3-one 26-monooxygenase. The enzyme can receive electrons from ferredoxin reductase in vitro, its natural electron donor is not known yet." +"1.14.14.27","The enzyme, characterized from the bacterium Rhizobium sp. strain MTP-10005, uses FADH2 as a substrate rather than a cofactor. FADH2 is provided by a dedicated EC 1.5.1.36, flavin reductase (NADH). The enzyme participates in the degradation of gamma-resorcylate and resorcinol. cf. EC 1.14.13.220, resorcinol 4-hydroxylase (NADH), and EC 1.14.13.219, resorcinol 4-hydroxylase (NADPH)." +"1.14.14.28","The enzyme, characterized from the bacterium Geobacillus thermodenitrificans NG80-2, is capable of converting alkanes ranging from C15 to C36 into their corresponding primary alcohols [1,2]. The FMNH2 cofactor is provided by an FMN reductase [3]." +"1.14.14.29","A P-450 (heme-thiolate) protein. Unlike EC 1.14.14.26, 24-hydroxycholesterol 7alpha-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent [2]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase." +"1.14.15.18",A P-450 (heme-thiolate) enzyme found in mammals. +"1.14.15.19","The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P-450, and uses ferredoxin as its electron donor [1]. It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione [2]." +"1.14.15.20","The enzyme, found in plants, algae, and cyanobacteria, participates in the biosynthesis of phytochromobilin and phytobilins. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. Unlike this enzyme, which uses ferredoxin as its electron donor, the electron source for the related mammalian enzyme (EC 1.14.14.18) is EC 1.6.2.4, NADPH---hemoprotein reductase." +"2.1.1.325","The enzyme, found in insects, is involved in the synthesis of juvenile hormone III, a sesquiterpenoid that regulates several processes including embryonic development, metamorphosis, and reproduction, in many insect species." +"2.1.1.326","The enzyme was originally characterized from bacteria that produce the tripeptides bialaphos and phosalacine, which inhibit plant and bacterial glutamine synthetases. It is a radical S-adenosyl-L-methionine (SAM) enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. According to the proposed mechanism, the reduced iron-sulfur center donates an electron to SAM, resulting in homolytic cleavage of the carbon-sulfur bond to form a 5'-deoxyadenosyl radical that abstracts the hydrogen atom from the P-H bond of the substrate, forming a phosphinate-centered radical. This radical reacts with methylcob(III)alamin to produce the methylated product and cob(II)alamin, which is reduced by an unknown donor to cob(I)alamin. A potential route for restoring the latter back to methylcob(III)alamin is a nucleophilic attack on a second SAM molecule. The enzyme acts in vivo on N-acetyldemethylphosphinothricin-L-alanyl-L-alanine or N-acetyl-demethylphosphinothricin-L-alanyl-L-leucine, the intermediates in the biosynthesis of bialaphos and phosalacine, respectively. This transformation produces the only example of a carbon-phosphorus-carbon linkage known to occur in nature." +"2.3.1.252","This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyltetracosanoate (C27-mycolipanoate). Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal." +"2.4.1.338","The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A." +"2.4.1.339","The enzyme, originally characterized from the thermophilic anaerobic bacterium Thermoanaerobacter sp. X514, catalyses a reversible reaction. cf. EC 2.4.1.340, 1,2-beta-oligomannan phosphorylase." +"2.4.1.340","The enzyme, originally characterized from the thermophilic anaerobic bacterium Thermoanaerobacter sp. X514, catalyses a reversible reaction. In the synthetic direction it produces oligosaccharides with a degree of polymerization (DP) of 3, 4 and 5. The phosphorolysis reaction proceeds to completion, although activity is highest when the substrate has at least three residues. cf. EC 2.4.1.339, beta-1,2-mannobiose phosphorylase." +"2.4.1.341","The enzyme, characterized from the bacterium Escherichia coli O55:H7, participates in the biosynthesis of an O-antigen. The reaction involves anomeric inversion, and does not require any metal ions. The enzyme is highly specific towards the acceptor, exclusively recognizing lacto-N-biose, but can accept GDP-L-fucose as the donor with almost the same activity as with GDP-beta-L-colitose." +"2.4.2.58","The enzyme, found in plants and mosses, catalyses the O-arabinosylation of hydroxyprolines in hydroxyproline-rich glycoproteins. The enzyme acts on the first hydroxyproline in the motif Val-hydroxyPro-hydroxyPro-Ser. " +"2.5.1.132","The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). The human sialic acid synthase (EC 2.5.1.57) is also able to catalyse the reaction. Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus." +"2.7.1.209","The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol." +"2.7.1.210","The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of erythritol and D-threitol." +"2.8.3.24","The enzyme, characterized from the bacterium Peptoclostridium difficile, participates in an L-leucine fermentation pathway. The reaction proceeds via formation of a covalent anhydride intermediate between a conserved aspartate residue and the acyl group of the CoA thioester substrate." +"3.1.3.101","The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A." +"3.1.3.102","Requires Mg2+. The enzyme, found in many isoforms purified from both bacteria and plants, is a member of the haloacid dehalogenase superfamily. Most of the isoforms have a wide substrate specificity [2], but isoforms specific for FMN also exist [3]." +"3.3.2.15",Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis. +"3.5.1.120","The enzyme, characterized from the bacterium Comamonas testosteroni CNB-1, converts 2-aminomuconate to 2-hydroxyhexa-2,4-dienedioate, unlike the enzymes from Pseudomonas, which produce (3E)-2-oxohex-3-enedioate (see EC 3.5.99.5, 2-aminomuconate deaminase). The enzyme also acts on 2-amino-5-chloromuconate." +"3.5.4.42","Requires Zn2+. This bacterial enzyme is involved in degradation of the herbicide atrazine. It can hydrolyse other N-substituted amino dihydroxy-s-triazine molecules, and prefers substrates with linear N-alkyl groups to those with branched alkyl groups. " +"4.2.1.164","A pyridoxal 5'-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine. Requires ferredoxin/ferredoxin reductase or flavodoxin/flavodoxin reductase [1]." +"4.2.1.165","The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 1.1.1.396, bacteriochlorophyllide-a dehydrogenase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme catalyses the hydration of a vinyl group on ring A, converting it to a hydroxyethyl group." +"4.2.1.166","The enzyme, characterized from the bacterium Streptomyces viridochromogenes, is involved in bialaphos biosynthesis. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase. The similar enzyme EC 4.2.1.3, aconitate hydratase, cannot catalyse this reaction." +"4.2.1.167","The enzymes from the bacteria Acidaminococcus fermentans and Clostridium symbiosum are involved in the fermentation of L-glutamate. The enzyme contains [4Fe-4S] clusters, FMNH2 and riboflavin. It must be activated by an activator protein. Once activated, it can catalyse many turnovers." +"4.2.3.154","The enzyme, characterized from the cyanobacterium Nostoc punctiforme PCC 73102, is involved in the biosynthesis of the sunscreen compound shinorine. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.155, 2-epi-valiolone synthase." +"4.2.3.155","The enzyme, characterized from the bacteria Actinosynnema mirum and Stigmatella aurantiaca DW4/3-1, produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase." +"4.3.1.31","The enzyme, characterized from the bacterium Rubrivivax benzoatilyticus JA2, requires no cofactors. It acts on L-phenylalanine and L-glutamate with about 60% of the activity with L-tryptophan, and on L-tyrosine, glycine, and L-alanine with about 30% of the activity." +"4.99.1.9","The enzyme, present in Gram-positive bacteria, participates in heme biosynthesis. It can also catalyse the reaction of EC 4.98.1.1, protoporphyrin ferrochelatase, at a much lower level." +"5.1.3.38","The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism." +"5.1.3.39","The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol." +"5.3.1.33","The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism." +"5.3.1.34","The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism." +"5.3.3.20","The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, uses radical chemistry to rearrange the positions of both a methyl group and a hydroxyl group. It consists of two subunits, the smaller one containing a cobalamin cofactor. It plays a central role in the degradation of assorted substrates containing a tert-butyl moiety." +"1.3.1.112","The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway. It catalyses the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols. The enzyme catalyses sequential hydride transfers to C-2 and C-4, respectively. Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers. cf. EC 1.3.1.77, anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]." +"1.14.11.54",Contains iron(II). Catalyses oxidative demethylation of mRNA N1-methyladenine. The enzyme is also involved in alkylation repair in DNA [2]. +"1.14.13.222","The aurachin C monooxygenase from the bacterium Stigmatella aurantiaca accepts both NADH and NADPH as cofactor, but has a preference for NADH. It catalyses the initial steps in the conversion of aurachin C to aurachin B. The FAD-dependent monooxygenase catalyses the epoxidation of the C2-C3 double bond of aurachin C, which is followed by a semipinacol rearrangement, causing migration of the farnesyl group from C3 to C4." +"1.14.13.223","A flavoprotein (FAD). The enzyme, characterized from the bacterium Streptosporangium sibiricum, is involved in the biosynthesis of the antitumor antibiotic sibiromycin. The enzyme is not active with free 3-hydroxy-4-methylanthranilate." +"1.14.13.224","The enzyme, characterized from the bacterium Chromobacterium violaceum, participates in the biosynthesis of the violet pigment violacein. The products, violaceinate and deoxyviolaceinate, undergo non-enzymic autooxidation into violacein and deoxyviolacein, respectively." +"1.14.13.225","The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization [1]. Free methionine is not a substrate [2]. The reaction is stereospecific and generates the (R)-sulfoxide [3]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1) [4,5]. " +"1.14.13.226","Contains FAD. The enzyme, characterized from the bacterium Gordonia sp. TY-5, is a Baeyer-Villiger type monooxygenase and participates in a propane utilization pathway." +"1.14.13.227","The enzyme, characterized from several bacterial strains, is a multicomponent dinuclear iron monooxygenase that includes a hydroxylase, an NADH-dependent reductase, and a coupling protein. The enzyme has several additional activities, including acetone monooxygenase (acetol-forming) and phenol 4-monooxygenase." +"1.14.14.30","The enzyme, characterized from the bacterium Streptomyces viridifaciens, is part of a two component system that also includes a flavin reductase, which provides reduced flavin mononucleotide for this enzyme. The enzyme, which is involved in the biosynthesis of the azoxy antibiotic valanimycin, has a similar activity with either FMNH2 or FADH2. It exhibits broad specificity, and also accepts propan-1-amine, butan-1-amine, butan-2-amine and benzylamine." +"1.14.14.31","A cytochrome P-450 heme-thiolate protein. Involved in the insect aggregation pheromone production. Isolated from the pine engraver beetle, Ips pini. A small amount of (S)-ipsdienol is also formed. In vitro it also hydroxylated (+)- and (-)-alpha-pinene, 3-carene, and (+)-limonene, but not alpha-phellandrene, (-)-beta-pinene, gamma-terpinene, or terpinolene." +"1.14.14.32","A microsomal cytochrome P-450 (heme-thiolate) protein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and 3beta-hydroxyandrost-5-en-17-one, leading to sex hormone biosynthesis. The activity of this reaction is dependent on the allosteric interaction of the enzyme with cytochrome b5 without any transfer of electrons from the cytochrome [2,4]. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter [1]." +"1.14.21.12","A cytochrome P-450 heme-thiolate enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine. cf. EC 1.14.21.2, (S)-cheilanthifoline synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline." +"1.17.8.1","This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 4.2.3.156, hydroxysqualene synthase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase." +"2.1.1.327","The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. The enzyme is active in vitro only in the presence of EC 1.14.13.218, 5-methylphenazine-1-carboxylate 1-monooxygenase." +"2.1.1.328","The enzyme, characterized from the bacterium Streptomyces griseus, catalyses the ultimate reaction in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2)." +"2.5.1.133","The enzyme catalyses the addition of a geranylgeranyl hydrophobic chain to bacteriochlorophyllide a via an ester bond with the 17-propionate residue. The side chain is later modified to a phytyl chain, resulting in bacteriochlorophyll a." +"2.5.1.134","A pyridoxal 5'-phosphate protein. The enzyme, purified from the bacterium Bacillus subtilis, also has a low activity with L-serine (cf. EC 4.2.1.22, cystathionine beta-synthase)." +"2.7.1.211","This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate." +"2.7.1.212","The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in an archaeal pathway for nucleoside degradation." +"2.7.1.213","The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in a pathway for nucleoside degradation. The enzyme can also act on deoxycytidine and uridine, but unlike EC 2.7.1.48, uridine kinase, it is most active with cytidine." +"2.7.1.214","The enzyme, characterized from the bacterium Streptomyces hygroscopicus var. jinggangensis, is involved in the biosynthesis of the antifungal agent validamycin A." +"2.7.1.215","The enzyme, characterized from the pathogenic bacterium Brucella abortus, which causes brucellosis in livestock, participates in erythritol catabolism. cf. EC 2.7.1.27, erythritol kinase (D-erythritol 4-phosphate-forming)." +"2.7.7.91","The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A." +"2.7.7.92","The enzyme is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus." +"2.7.7.93","The enzyme, characterized from the bacterium Streptomyces viridochromogenes, participates in the biosynthesis of the herbicide antibiotic bialaphos. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase." +"2.7.7.94","The mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to the phenolphthiocerol/phthiocerol polyketide synthase." +"2.8.3.25","The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bile acid 7alpha-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. Clostridium scindens possesses two forms of the enzyme, encoded by the baiF and baiK genes. While the enzymes have a broad acceptor specificity and can use allocholate, ursodeoxycholate, and beta-muricholate, the donor specificity is more strict. BaiF acts on lithocholoyl-CoA and deoxycholoyl-CoA, and BaiK acts only on the latter." +"3.1.1.100","This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green filamentous bacteria (Chloroflexaceae), catalyses the first committed step in the biosynthesis of bacteriochlorophylls c, d, and e, the removal of the C-132-methylcarboxyl group from chlorophyllide a. The reaction is very similar to the conversion of pheophorbide a to pyropheophorbide a during chlorophyll a degradation, which is catalysed by EC 3.1.1.82, pheophorbidase." +"3.1.1.101","The enzyme, isolated from the bacterium Ideonella sakaiensis, also produces small amounts of terephthalate (cf. EC 3.1.1.102, mono(ethylene terephthalate) hydrolase). The reaction takes place on PET-film placed in solution." +"3.1.1.102","The enzyme, isolated from the bacterium Ideonella sakaiensis, has no activity with poly(ethylene terephthalate) PET (cf. EC 3.1.1.101, poly(ethylene terephthalate) hydrolase)." +"3.1.2.32","The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the production of the signal molecule 2-heptyl-4(1H)-quinolone (HHQ)." +"3.1.3.103","The enzyme, characterized from the bacterium Bacteroides thetaiotaomicron, is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus." +"3.1.3.104","Requires Mg2+. The enzyme, which is found in plants and bacteria, is part of a pathway for riboflavin biosynthesis. Most forms of the enzyme has a broad substrate specificity [1,3]." +"3.2.1.197","The enzyme, characterized from multiple bacterial species, catalyses the hydrolysis of terminal, non-reducing D-mannose residues from beta-1,2-mannotriose and beta-1,2-mannobiose. The mechanism involves anomeric inversion, resulting in the release of alpha-D-mannopyranose. Activity with beta-1,2-mannotriose or higher oligosaccharides is higher than that with beta-1,2-mannobiose." +"3.2.1.198","The enzyme, characterized from the gut bacteria Bacteroides thetaiotaomicron and Bacteroides xylanisolvens, can also catalyse the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase." +"3.2.1.199","The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, hydrolyses terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol using a retaining mechanism. The enzyme belongs to the glycosyl hydrolase GH31 family." +"3.5.4.43","Contains Zn2+. This bacterial enzyme is involved in degradation of the herbicide atrazine. The enzyme has a broad substrate range, and requires a monohydroxylated s-triazine ring with a minimum of one primary or secondary amine substituent and either a chloride or amine leaving group. It catalyses both deamination and dechlorination reactions." +"4.1.1.103","The enzyme, characterized from several bacterial strains, is involved in the degradation of gamma-resorcylate. It contains a zinc ion and a water molecule at the active site. The reaction is reversible, but equilibrium greatly favors the decarboxylation reaction." +"4.1.99.22","The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). In bacteria and plants the reaction is catalysed by MoaA and Cnx2, respectively. In mammals it is catalysed by the MOCS1A domain of the bifunctional MOCS1 protein, which also catalyses EC 4.6.1.17, cyclic pyranopterin monophosphate synthase. The enzyme belongs to the superfamily of radical S-adenosyl-L-methionine (radical SAM) enzymes, and contains two oxygen-sensitive FeS clusters." +"4.2.1.168","This enzyme, involved in beta-L-colitose biosynthesis, is a unique vitamin-B6-dependent enzyme. In the first step of catalysis, the bound pyridoxal phosphate (PLP) cafactor is transaminated to the pyridoxamine 5'-phosphate (PMP) form of vitamin B6, using L-glutamate as the amino group donor. The PMP cofactor then forms a Schiff base with the sugar substrate and the resulting adduct undergoes a 1,4-dehydration to eliminate the 3-OH group. Hydrolysis of the product from the enzyme restores the PLP cofactor and results in the release of an unstable enamine intermediate. This intermediate tautomerizes to form an imine form, which hydrolyses spontaneously, releasing ammonia and forming the final product." +"4.2.3.156","This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 1.17.8.1, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase." +"4.4.1.34","The enzyme, characterized from the bacterium Rhodococcus sp. AD45, is involved in isoprene degradation. The enzyme can catalyse the glutathione-dependent ring opening of various epoxides, but the highest activity is with (3R)-3,4-epoxy-3-methylbut-1-ene, which is derived from isoprene by EC 1.14.13.69, alkene monooxygenase." +"4.6.1.17","The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). In bacteria and plants the reaction is catalysed by MoaC and Cnx3, respectively. In mammals the reaction is catalysed by the MOCS1B domain of the bifuctional MOCS1 protein, which also catalyses EC 4.1.99.22, GTP 3',8-cyclase." +"6.2.1.47",The enzyme ligates medium chain fatty acids (with aliphatic chain of 6-12 carbons) to an acyl-carrier protein. +"1.5.3.23","The enzyme, characterized from the bacterium Ochrobactrum sp. G-1, contains an FAD cofactor. The catalytic cycle starts with a reduction of the FAD cofactor by one molecule of glyphosate, yielding reduced FAD and a Schiff base of aminomethylphosphonate with glyoxylate that is hydrolysed to the single components. The reduced FAD is reoxidized by oxygen, generating water and an oxygenated flavin intermediate, which catalyses the oxygenation of a second molecule of glyphosate, forming the second pair of aminomethylphosphonate and glyoxylate." +"1.8.5.5","The enzyme, characterized from the bacterium Salmonella enterica, is similar to EC 1.17.5.3, formate dehydrogenase-N. It contains a molybdopterin-guanine dinucleotide, five [4Fe-4S] clusters and two heme b groups. The reaction occurs in vivo in the direction of thiosulfate disproportionation, which is highly endergonic. It is driven by the proton motive force that occurs across the cytoplasmic membrane." +"1.8.5.6","This membrane-bound bacterial enzyme catalyses the direct oxidation of sulfite to sulfate in the cytoplasm. The enzyme, characterized from the bacteria Ruegeria pomeroyi and Allochromatium vinosum, is a complex that consists of a membrane anchor (SoeC) and two cytoplasmic subunits: an iron-sulfur protein (SoeB) and a molybdoprotein that contains a [4Fe-4S] iron-sulfur cluster (SoeA). cf. EC 1.8.2.1, sulfite dehydrogenase (cytochrome)." +"1.10.3.16","Requires FMN. The enzyme, isolated from the bacteria Pseudomonas fluorescens 2-79 and Burkholderia lata 383, is involved in biosynthesis of the reduced forms of phenazine, phenazine-1-carboxylate, and phenazine-1,6-dicarboxylate, where it catalyses multiple reactions." +"1.14.12.25","The enzyme, characterized from several Pseudomonas strains, is involved in the degradation of p-cymene and p-cumate. It comprises four components: a ferredoxin, a ferredoxin reductase, and two subunits of a catalytic component. The enzyme can also act on indole, transforming it to the water-insoluble blue dye indigo." +"1.14.13.228","Although believed to occur in plants, the enzyme has so far been characterized only from the rice blast fungus, Magnaporthe oryzae. The fungus strategically deploys the enzyme to hydroxylate and inactivate endogenous jasmonate to evade the jasmonate-based innate immunity in rice plants." +"1.14.13.229","The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, is a Rieske nonheme mononuclear iron oxygenase. It can also act, with lower efficiency, on propan-2-ol, converting it to propane-1,2-diol. Depending on the substrate, the enzyme also catalyses EC 1.14.19.48, tert-amyl alcohol desaturase." +"1.14.13.230","The enzyme, characterized from the bacterium Thauera butanivorans, is similar to EC 1.14.13.25, methane monooxygenase (soluble), but has a very low activity with methane. It comprises three components - a carboxylate-bridged non-heme di-iron center-containing hydroxylase (made of three different subunits), a flavo-iron sulfur-containing NADH-oxidoreductase, and a small regulatory component protein. The enzyme can also act on other C3-C6 linear and branched aliphatic alkanes with lower activity." +"1.14.13.231",A flavoprotein (FAD). This bacterial enzyme confers resistance to all clinically relevant tetracyclines when expressed under aerobic conditions. The hydroxylated products are very unstable and lead to intramolecular cyclization and non-enzymic breakdown to undefined products. +"1.14.13.232","The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. That bacterium possesses two enzymes that can catalyse the reaction - OxyE is the main isozyme, while OxyL has a lower activity. OxyL is bifunctional, and its main function is EC 1.14.13.233, 4-hydroxy-6-methylpretetramide 12a-monooxygenase. Contains FAD." +"1.14.13.233","Contains FAD. The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. The enzyme is bifunctional, and can also catalyse EC 1.14.13.232, 6-methylpretetramide 4-monooxygenase." +"1.14.13.234","The enzyme, characterized from the bacterium Streptomyces rimosus, is bifunctional, catalysing two successive monooxygenation reactions. It starts by catalysing the stereospecific hydroxylation of anhydrotetracycline at C-6 (EC 1.14.13.38). If the released product is captured by EC 1.3.98.4, 5a,11a-dehydrotetracycline dehydrogenase (OxyR), it is reduced to tetracycline. However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C-5, producing 5a,11a-dehydrooxytetracycline, which, following the action of OxyR, becomes oxytetracycline." +"1.14.14.33","The enzyme is part of a two component system that also includes EC 1.5.1.42, FMN reductase (NADH), which provides reduced flavin mononucleotide for this enzyme. It acts on EDTA only when it is complexed with divalent cations such as Mg2+, Zn2+, Mn2+, Co2+, or Cu2+. While the enzyme has a substrate overlap with EC 1.14.14.10, nitrilotriacetate monooxygenase, it has a much wider substrate range, which includes nitrilotriacetate (NTA) and diethylenetriaminepentaacetate (DTPA) in addition to EDTA." +"1.14.14.34","The enzyme, characterized from Pseudomonas strains, allows the organisms to utilize methanesulfonate as their sulfur source. It acts in combination with a dedicated NADH-dependent FMN reductase (EC 1.5.1.42), which provides it with reduced FMN. cf. EC 1.14.13.111, methanesulfonate monooxygenase (NADH)." +"1.14.14.35","The enzyme, characterized from Pseudomonas spp., is involved in a dimethyl sulfide degradation pathway. It is dependent on NAD(P)H-dependent FMN reductase (EC 1.5.1.38, EC 1.5.1.39, or EC 1.5.1.42), which provides it with reduced FMN. The product, methanesulfinate, is oxidized spontaneously to methanesulfonate in the presence of dioxygen and FMNH2." +"1.14.14.36",A cytochrome P-450 (heme-thiolate) protein. The enzyme from Sorghum is involved in the biosynthesis of the cyanogenic glucoside dhurrin. In Sinapis alba (white mustard) the enzyme is involved in the biosynthesis of the glucosinolate sinalbin. +"1.14.14.37","This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum. It catalyses three different activities - isomerization of the (E) isomer to the (Z) isomer, dehydration, and C-hydroxylation." +"1.14.15.21","A flavoprotein (FAD) that is active under conditions of low light. Along with EC 1.23.5.1, violaxanthin de-epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle, which is involved in protecting the plant against damage by excess light. It will also epoxidize lutein in some higher-plant species." +"1.14.15.22","A P-450 (heme-thiolate) enzyme found in the bacterium Streptomyces griseolus. cf. EC 1.14.14.24, vitamin D 25-hydroxylase and EC 1.14.15.18, calcidiol 1-monooxygenase." +"1.14.19.48","The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, is a Rieske nonheme mononuclear iron oxygenase. It can also act, with lower efficiency, on butan-2-ol, converting it to but-1-en-3-ol. Depending on the substrate, the enzyme also catalyses EC 1.14.13.229, tert-butanol monooxygenase." +"1.14.19.49","The enzyme, characterized from the bacterium Streptomyces aureofaciens, is a member of the flavin-dependent halogenase family. The enzyme forms a lysine chloramine intermediate on an internal lysine residue before transferring the chlorine to the substrate. It is stereo-selective for the 4S (natural) isomer of tetracycline. FADH2 is provided by a dedicated EC 1.5.1.36, flavin reductase (NADH)." +"1.14.19.50","A P-450 (heme-thiolate) enzyme. The enzyme, characterized from Narcissus pseudonarcissus (daffodil), forms the two enantiomers of the Amaryllidacea alkaloid noroxomaritidine by catalysing intramolecular oxidative para-para' phenol coupling. The oxidation involves molecular oxygen without its incorporation into the product." +"1.17.3.4","Even though oxygen is consumed, molecular oxygen is not incorporated into the product. Catalysis starts by incorporation of an oxygen atom from a water molecule into the substrate. The naphthalene-1,2,4,8-tetrol intermediate is then oxidized by molecular oxygen, which is reduced to water. Also acts on 1,4-naphthoquinone, naphthazarin and 2-chloro-1,4-naphthoquinone." +"1.17.98.2","The enzyme, found in green sulfur bacteria (Chlorobiaceae), is a radical S-adenosyl-L-methionine (AdoMet) enzyme and contains a [4Fe-4S] cluster. It catalyses two consecutive hydroxylation reactions of the C-7 methyl group of bacteriochlorophyllide c to form a geminal diol intermediate that spontaneously dehydrates to produce the formyl group of bacteriochlorophyllide e." +"1.19.1.1","A flavoprotein (FAD). This activity occurs in some prokaryotes and algae that possess flavodoxin, and provides low-potential electrons for a variety of reactions such as nitrogen fixation, sulfur assimilation and amino acid biosynthesis. In photosynthetic organisms it is involved in the photosynthetic electron transport chain. The enzyme also catalyses EC 1.18.1.2, ferredoxin---NADP+ reductase." +"1.21.98.3","This radical AdoMet enzyme participates in the biosynthesis of chlorophyllide a in anaerobic bacteria, catalysing the formation of an isocyclic ring. Contains a [4Fe-4S] cluster and a cobalamin cofactor. The same transformation is achieved in aerobic organisms by the oxygen-dependent EC 1.14.13.81, magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase. Some facultative phototrophic bacteria, such as Rubrivivax gelatinosus, possess both enzymes." +"2.1.1.329","The enzyme, found in plants and cyanobacteria, catalyses the final step in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is specific for the quinol form of the substrate, and does not act on the quinone form [3]." +"2.1.1.330","The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs." +"2.1.1.331","This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green flimentous bacteria (Chloroflexaceae), is a radical S-adenosyl-L-methionine (AdoMet) enzyme and contains a [4Fe-4S] cluster. It adds a methyl group at the C-121 position of bacteriochlorophylls of the c, d and e types. This methylation plays a role in fine-tuning the structural arrangement of the bacteriochlorophyll aggregates in chlorosomes and therefore directly influences the chlorosomes absorption properties." +"2.1.1.332","This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green flimentous bacteria (Chloroflexaceae), is a radical S-adenosyl-L-methionine (AdoMet) enzyme and contains a [4Fe-4S] cluster. It adds one or two methyl groups at the C-82 position of bacteriochlorophylls of the c, d, and e types. These methylations play a role in fine-tuning the structural arrangement of the bacteriochlorophyll aggregates in chlorosomes and therefore directly influence chlorosomal absorption properties. " +"2.1.1.333","The enzyme, found in green sulfur bacteria (Chlorobiaceae) and green flimentous bacteria (Chloroflexaceae), catalyses the methylation of the C-20 methine bridge position in bacteriochlorophyllide d, forming bacteriochlorophyllide c." +"2.1.1.334","The enzyme, found in many bacterial taxa, is involved in a pathway that converts L-methionine to dimethyl sulfide." +"2.1.1.335","The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics." +"2.1.1.336","The enzyme, characterized from the plants Nerine bowdenii and Narcissus pseudonarcissus (daffodil), participates in the biosynthesis of alkaloids produced by plants that belong to the Amaryllidaceae family." +"2.3.1.253","The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase. The mechanism involves the cyclization of an activated 3,5-dioxoheptanedioate intermediate. The enzyme exhibits broad substrate specificity, and can accept C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming 6-(polyoxoalkyl)-alpha-pyrones by sequential condensation with malonyl-CoA." +"2.3.1.254","N-terminal acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatB complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to Asn, Asp, Gln, or Glu residues at the second position." +"2.3.1.255","N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. The NatA complex is found in all eukaryotic organisms, and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val residues, that became available after removal of the initiator methionine." +"2.3.1.256","N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing. The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues." +"2.3.1.257","N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. NatD is found in all eukaryotic organisms, and acetylates solely the serine residue at the N-terminus of histones H2A or H4. Efficient recognition and acetylation by NatD requires at least the first 30 to 50 highly conserved amino acid residues of the histone N terminus." +"2.3.1.258","N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis. It may also play a role in membrane targeting and gene silencing. NatE is found in all eukaryotic organisms and plays an important role in chromosome resolution and segregation. It specifically targets N-terminal L-methionine residues attached to Lys, Val, Ala, Tyr, Phe, Leu, Ser, and Thr. There is some substrate overlap with EC 2.3.1.256, N-terminal methionine Nalpha-acetyltransferase NatC. In addition, the acetylation of Met followed by small residues such as Ser, Thr, Ala, or Val suggests a kinetic competition between NatE and EC 3.4.11.18, methionyl aminopeptidase. The enzyme also has the activity of EC 2.3.1.48, histone acetyltransferase, and autoacetylates several of its own lysine residues." +"2.3.1.259","N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis. NatF is found only in higher eukaryotes, and is absent from yeast. Unlike other Nat systems the enzyme is located in the Golgi apparatus. It faces the cytosolic side of intracellular membranes, and specifically acetylates transmembrane proteins whose N termini face the cytosol. NatF targets N-terminal L-methionine residues attached to Lys, Ser, Val, Leu, Gln, Ile, Tyr and Thr residues." +"2.3.1.260","The synthesis, in the bacterium Streptomyces rimosus, of the tetracycline antibiotics core skeleton requires a minimal polyketide synthase (PKS) consisting of a ketosynthase (KS), a chain length factor (CLF), and an acyl-carrier protein (ACP). Initiation involves an amide-containing starter unit that becomes the C-2 amide that is present in the tetracycline compounds. Following the initiation, the PKS catalyses the iterative condensation of 8 malonyl-CoA molecules to yield the polyketide backbone of tetracycline. Throughout the proccess, the nascent chain is attached to the OxyC acyl-carrier protein." +"2.3.2.29","The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-aspartate or L-glutamate residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. cf. EC 2.3.2.6, lysine/arginine leucyltransferase, and EC 2.3.2.8, arginyltransferase." +"2.3.3.17","The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. Two forms are known - MAM1 catalyses only only the first two rounds of methionine chain elongation, while MAM3 catalyses all six cycles, up to formation of L-hexahomomethionine." +"2.4.1.342","The enzyme, found in Mycobacteria, can also use UDP-alpha-D-glucose with much lower catalytic efficiency." +"2.5.1.135","The enzyme, characterized from several Streptomyces strains, is involved in the biosynthesis of the antifungal agent validamycin A." +"2.7.7.95","The enzyme, found in certain mycobacteria, catalyses the activation of the methylated long-chain fatty acids, mycocerosic acids, by adenylation. The activated acids are transferred to the two hydroxyl groups of phthiocerols and phenolphthiocerols by PapA5, leading to formation of dimycocerosates (DIM) and dimycocerosyl triglycosyl phenolphthiocerol (PGL), respectively." +"2.7.7.96","The human enzyme produces ATP in nuclei in situations of high energy demand, such as chromatin remodeling. The reaction is dependent on the presence of diphosphate. In its absence the enzyme catalyses the reaction of EC 3.6.1.13, ADP-ribose diphosphatase. cf. EC 2.7.7.35, ADP ribose phosphorylase." +"2.7.7.97","The enzyme, characterized from the bacteria Streptomyces anulatus and Streptosporangium sibiricum, activates 3-hydroxy-4-methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein." +"2.7.8.43","The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A." +"2.7.8.44",Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls. This enzyme adds the first glycerol unit to the disaccharide linker of the teichoic acid. +"3.4.19.15","The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolysing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. The enzyme contains Zn2+. cf. EC 3.4.19.12, ubiquitinyl hydrolase 1. In peptidase family M67. " +"3.5.1.121","This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn. Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule." +"3.5.1.122","This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln. Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule." +"3.5.1.123","The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the opposite reaction from that catalysed by EC 6.3.1.18, gamma-glutamylanilide synthase, which is part of an aniline degradation pathway. Its purpose is likely to maintain a low concentration of N5-phenyl-L-glutamine, which is potentially toxic." +"3.5.1.124","The enzyme, previously thought to be a glyoxalase, acts on glycated L-arginine, L-lysine, and L-cysteine residues within proteins that have been attacked and modified by glyoxal or 2-oxopropanal. The attack forms hemithioacetal in the case of cysteines and aminocarbinols in the case of arginines and lysines. The enzyme repairs the amino acids, releasing glycolate or lactate (70-80% (S)-lactate and 20-30% (R)-lactate), depending on whether the attacking agent was glyoxal or 2-oxopropanal, respectively [3,4]. " +"3.6.1.68","The enzyme, characterized from roses, is involved in a cytosolic pathway for the biosynthesis of free monoterpene alcohols that contribute to fragrance. In vitro the enzyme also acts on (2E,6E)-farnesyl diphosphate." +"4.2.1.169","This enzyme, found in green sulfur bacteria (Chlorobiaceae) and green flimentous bacteria (Chloroflexaceae), is involved in the biosynthesis of bacteriochlorophylls c, d and e. It acts in the direction of hydration, and the hydroxyl group that is formed is essential for the ability of the resulting bacteriochlorophylls to self-aggregate in the chlorosomes, unique light-harvesting antenna structures found in these organisms. The product is formed preferentially in the (R)-configuration." +"4.2.1.170","The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. By catalysing a dehydration of a 2-[(omega-methylsulfanyl)alkyl]maleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates. The enzyme is a heterodimer comprising a large and a small subunits. The large subunit can also bind to an alternative small subunit, forming EC 4.2.1.33, 3-isopropylmalate dehydratase, which participates in L-leucine biosynthesis." +"1.1.99.42","The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6). It is membrane bound and contains FAD. The enzyme has been assayed in vitro in the presence of the artificial electron acceptor dichloroindophenol (DCPIP)." +"1.1.1.404","Contains FMN. The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, participates in the degradation of pentachlorophenol. " +"1.1.1.405","Requires Zn2+. The enzyme, characterized in bacteria, is specific for NADP. It is part of the synthesis pathway of CDP-ribitol. In Haemophilus influenzae it is part of a multifunctional enzyme also catalysing EC 2.7.7.40, D-ribitol-5-phosphate cytidylyltransferase. cf. EC 1.1.1.137, ribitol-5-phosphate 2-dehydrogenase." +"1.1.1.406","The enzyme, characterized in the bacterium Rhodobacter sphaeroides, has a wide subtrate specificity. In addition to galactitol, it primarily oxidizes D-threitol and xylitol, and in addition to L-tagatose, it primarily reduces L-erythrulose, D-ribulose and L-glyceraldehyde. It is specific for NAD+. The enzyme also shows activity with D-tagatose (cf. EC 1.1.1.16, galactitol 2-dehydrogenase)." +"1.1.1.407","The enzyme, characterized in Agrobacterium fabrum C58, also has low activity with D-mannitol and D-arabinitol. It is part of a D-altritol degradation pathway." +"1.1.5.12",The enzyme is an FAD-dependent peripheral membrane dehydrogenase that participates in respiration. Electrons derived from D-lactate oxidation are transferred to the membrane soluble quinone pool. +"1.1.98.6","The enzyme, which is expressed in the bacterium Escherichia coli during anaerobic growth, contains an iron sulfur center. The active form of the enzyme contains an oxygen-sensitive glycyl (1-amino-2-oxoethan-1-yl) radical that is generated by the activating enzyme NrdG via chemistry involving S-adenosylmethionine (SAM) and a [4Fe-4S] cluster. The glycyl radical is involved in generation of a transient thiyl (sulfanyl) radical on a cysteine residue, which attacks the substrate, forming a ribonucleotide 3'-radical, followed by water loss to form a ketyl (alpha-oxoalkyl) radical. The ketyl radical gains an electron from a cysteine residue and a proton from formic acid, forming 3'-keto-deoxyribonucleotide and generating a thiosulfuranyl (1lambda4-disulfan-1-yl) radical bridge between methionine and cysteine residues. Oxidation of formate by the thiosulfuranyl radical results in the release of CO2 and regeneration of the thiyl radical. cf. EC 1.17.4.1, ribonucleoside-diphosphate reductase and EC 1.17.4.2, ribonucleoside-triphosphate reductase (thioredoxin)." +"1.1.99.40","The enzyme, characterized in the yeast Saccharomyces cerevisiae, also functions as EC 1.1.2.4, D-lactate dehydrogenase (cytochrome), and is active with oxaloacetate as electron acceptor forming (R)-malate. " +"1.3.8.13","The enzyme has been purified from the bacterium Escherichia coli O44 K74, in which it forms a complex with EC 2.8.3.21, L-carnitine CoA-transferase. The electron donor is believed to be an electron-transfer flavoprotein (ETF) encoded by the fixA and fixB genes." +"1.3.99.38","The enzyme from the bacterium Mycobacterium tuberculosis reduces the beta-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD." +"1.4.1.25","The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.99.6, D-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine." +"1.4.1.26","The enzyme, characterized from an unknown bacterium in an environmental sample, has some activity with (2R,4R)-2,4-diaminopentanoate. It has very low activity with NADP+ (cf. EC 1.4.1.12, 2,4-diaminopentanoate dehydrogenase). " +"1.4.3.25",Contains FAD. The enzyme from cyanobacteria can also act on other basic amino acids with lower activity. The enzyme from the bacterium Pseudomonas sp. TPU 7192 is highly specific. +"1.5.1.51","The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B." +"1.8.2.5","The enzyme is found in sulfate-reducing bacteria. The source of the electrons is molecular hydrogen, via EC 1.12.2.1, cytochrome-c3 hydrogenase. The organisms utilize the sulfite that is produced for energy generation by EC 1.8.1.22, dissimilatory sulfite reductase system." +"1.8.5.7","This type of enzymes, which are found in bacteria, halobacteria, fungi, and plants, catalyse the glutathione-dependent reduction of glutathionyl-hydroquinones. The enzyme from the bacterium Sphingobium chlorophenolicum can act on halogenated substrates such as 2,6-dichloro-3-(glutathione-S-yl)-hydroquinone and 2,3,5-trichloro-6-(glutathione-S-yl)-hydroquinone. Substrates for these enzymes are often formed spontaneously by interaction of benzoquinones with glutathione." +"1.14.11.55","Requires Fe2+ and ascorbate. The enzyme, found in bacteria, is specific for ectoine." +"1.14.11.56","Requires Fe2+ and ascorbate. The enzyme, isolated from Rhizobium species, only produces cis-4-hydroxy-L-proline (cf. EC 1.14.11.57, L-proline trans-4-hydroxylase)." +"1.14.11.57","Requires Fe2+ and ascorbate. The enzyme, isolated from multiple bacterial species, only produces trans-4-hydroxy-L-proline (cf. EC 1.14.11.56, L-proline cis-4-hydroxylase)." +"1.14.14.38","A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses two successive N-hydroxylations of L-valine, the committed step in the biosynthesis of the cyanogenic glucoside linamarin in Manihot esculenta (cassava). The product of the two hydroxylations, N,N-dihydroxy-L-valine, is labile and undergoes dehydration and decarboxylation that produce the (E) isomer of the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The enzyme can also accept L-isoleucine as substrate, with a lower activity. It is different from EC 1.14.14.39, isoleucine N-monooxygenase, which prefers L-isoleucine." +"1.14.14.39","This cytochrome P-450 (heme-thiolate) enzyme, found in plants, catalyses two successive N-hydroxylations of L-isoleucine, the committed step in the biosynthesis of the cyanogenic glucoside lotaustralin. The product of the two hydroxylations, N,N-dihydroxy-L-isoleucine, is labile and undergoes dehydration followed by decarboxylation, producing the oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme. The enzyme can also accept L-valine, but with a lower activity. cf. EC 1.14.14.38, valine N-monooxygenase." +"1.14.14.40","This cytochrome P-450 (heme-thiolate) enzyme, found in plants, catalyses two successive N-hydroxylations of L-phenylalanine, a committed step in the biosynthesis of benzylglucosinolate and the cyanogenic glucosides (R)-prunasin and (R)-amygdalin. The product of the two hydroxylations, N,N-dihydroxy-L-phenylalanine, is labile and undergoes dehydration followed by decarboxylation, producing an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme." +"1.14.14.41","This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucosides lotaustralin and linamarin. It catalyses three different activities - isomerization of its substrate, the (E) isomer, to the (Z) isomer, dehydration, and C-hydroxylation." +"1.14.14.42","This plant cytochrome P-450 (heme thiolate) enzyme is involved in methionine-derived aliphatic glucosinolates biosynthesis. It catalyses two successive N-hydroxylations, which are followed by dehydration and decarboxylation. CYP79F1 from Arabidopsis thaliana can metabolize mono-, di-, tri-, tetra-, penta-, and hexahomomethionine to their corresponding aldoximes, while CYP79F2 from the same plant can only metabolize penta- and hexahomomethionine." +"1.14.14.43","This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of glucosinolates in plants. The enzyme catalyses an N-hydroxylation of the E isomer of omega-(methylsulfanyl)alkanal oximes, forming an aci-nitro intermediate that reacts non-enzymically with glutathione to produce an N-alkyl-thiohydroximate adduct, the committed precursor of glucosinolates. In the absence of a thiol compound, the enzyme is suicidal, probably due to interaction of the reactive aci-nitro intermediate with active site residues." +"1.14.99.53","The enzyme cleaves chitin in an oxidative manner, releasing fragments of chitin with an N-acetylamino-D-glucono-1,5-lactone at the reducing end. The initially formed lactone at the reducing end of the shortened chitin chain quickly hydrolyses spontaneously to the aldonic acid. In vitro ascorbate can serve as reducing agent. The enzyme contains copper at the active site." +"1.21.99.5","This enzyme allows the common pollutant tetrachloroethene to support bacterial growth and is responsible for disposal of a number of chlorinated hydrocarbons. The reaction occurs in the reverse direction. The enzyme also reduces trichloroethene to dichloroethene. Although the physiological reductant is unknown, the supply of reductant in some organisms involves menaquinol, which is reduced by molecular hydrogen via the action of EC 1.12.5.1, hydrogen:quinone oxidoreductase. The enzyme contains a corrinoid and two iron-sulfur clusters. Methyl viologen can act as electron donor in vitro." +"2.1.1.337","The enzyme from opium poppy (Papaver somniferum) can also methylate (R)-reticuline, tetrahydropapaverine, (S)-glaucine and (S)-bulbocapnine. It is involved in the biosynthesis of the quaternary benzylisoquinoline alkaloid magnoflorine." +"2.1.1.338",Found in hops (Humulus lupulus). The enzyme can also methylate xanthogalenol. +"2.1.1.339","The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin." +"2.3.1.261","The enzyme is part of the biosynthetic pathway of phenolphthiocerol, a lipid that serves as a virulence factor of pathogenic mycobacteria. It catalyses the elongation of 4-hydroxybenzoate that is loaded on its acyl-carrier domain to form (4-hydroxyphenyl)alkanoate intermediates. The enzyme adds either 8 or 9 malonyl-CoA units, resulting in formation of 17-(4-hydroxyphenyl)heptadecanoate or 19-(4-hydroxyphenyl)nonadecanoate, respectively. As the enzyme lacks a thioesterase domain [1], the product remains loaded on the acyl-carrier domain at the end of catalysis, and has to be hydrolysed by an as-yet unknown mechanism." +"2.3.1.262","The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl-3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone. The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl-CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone. However, when EC 3.1.2.32, 2-aminobenzoylacetyl-CoA thioesterase, is present, it removes the CoA moiety from the product, forming the stable (2-aminobenzoyl)acetate." +"2.3.1.263","A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the bacterium Clostridium sticklandii, is part of a degradation pathway of ornithine. It is specific for acetyl-CoA and D-alanine." +"2.3.3.18","The enzyme, characterized from the bacterium Streptomyces hygroscopicus, participates in the pathway for bialaphos biosynthesis. It requires a divalent metal ion and can also act on oxaloacetate." +"2.4.1.343","The enzyme is involved in the the biosynthesis of the O-antigen repeating unit of Escherichia coli O3. Requires a divalent metal ion (Mn2+, Mg2+ or Fe2+). cf. EC 2.4.1.303, UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase." +"2.4.1.344","The enzyme acts on a glycoconjugates where R (see reaction) is a glycoprotein or glycosphingolipid. The recognized moiety of the substrate is known as a type 2 histo-blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 2 antigen. Humans possess two enzymes able to catalyse this reaction, encoded by the FUT1 and FUT2 genes (also known as the H and Secretor genes, respectively), but only FUT1 is expressed in red blood cells. cf. EC 2.4.1.69, type 1 galactoside alpha-(1,2)-fucosyltransferase." +"2.5.1.136","The enzyme, characterized from hop (Humulus lupulus), acts on phlorisovalerophenone, phlormethylbutanophenone, and phlorisobutanophenone during the synthesis of bitter acids. It also acts with much lower activity on naringenin chalcone. Forms a complex with EC 2.5.1.137, 2-acyl-4-prenylphloroglucinol 6-prenyltransferase, which catalyses additional prenylation reactions. Requires Mg2+." +"2.5.1.137","The enzyme, characterized from hop (Humulus lupulus), catalyses two successive prenylations of a 2-acyl-4-prenylphloroglucinol during the synthesis of bitter acids. Forms a complex with EC 2.5.1.136, 2-acylphloroglucinol 4-prenyltransferase, which catalyses the initial prenylation of the substrates. Requires Mg2+." +"2.5.1.138","The enzyme, characterized from the plant Citrus limon, is specific for geranyl diphosphate as a prenyl donor. It also has low activity with the coumarins 5,7-dihydroxycoumarin and 5-methoxy-7-hydroxycoumarin." +"2.5.1.139","The enzyme from parsley (Petroselinum crispum) is specific for umbelliferone and prenyl diphosphate. A minor product is osthenol, which is produced by transfer of the prenyl group to C-8 of umbelliferone." +"2.6.1.111","The enzyme, found in bacteria, is part of a L-lysine degradation pathway. The enzyme is also active with other beta-amino compounds such as 3-amino-5-methylhexanoyl-CoA and 3-amino-3-phenylpropanoyl-CoA." +"2.6.1.112","A pyridoxal 5'-phosphate protein. The protein, found in bacteria, can use other amino-group acceptors, but is specific for (S)-ureidoglycine." +"2.7.1.216","The enzyme, found in plants and animals, can also use other nucleotide triphosphates as phosphate donor, albeit less efficiently. The plant enzyme can also use geraniol and geranylgeraniol as substrates with lower activity, but not farnesyl phosphate (cf. EC 2.7.4.32, farnesyl phosphate kinase) [2]." +"2.7.4.32","The enzyme, found in plants and animals, is specific for CTP as phosphate donor. It does not use farnesol as substrate (cf. EC 2.7.1.216, farnesol kinase)." +"2.7.7.98","This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase." +"2.7.8.45","Involved in the biosynthesis of teichoic acid linkage units in the cell walls of some bacteria such as Staphylococcus aureus. This enzyme adds a second glycerol unit to the disaccharide linker of the teichoic acid. cf. EC 2.7.8.12, teichoic acid poly(glycerol phosphate) polymerase." +"2.7.8.46",Involved in the biosynthesis of teichoic acid linkage units in the cell wall of Bacillus subtilis W23. This enzyme adds the first ribitol unit to the disaccharide linker of the teichoic acid. +"2.7.8.47",Involved in the biosynthesis of teichoic acid linkage units in the cell wall of Bacillus subtilis W23. This enzyme adds the 25-35 ribitol units to the linker molecule. +"3.1.11.7","Aprataxin is a DNA-binding protein involved in different types of DNA break repair. The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus. It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, ribonuclease H, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction. Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined. The enzyme also possesses the activities of EC 3.1.11.8, guanosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.1.12.2, DNA-3'-diphospho-5'-guanosine diphosphatase." +"3.1.11.8","Aprataxin is a DNA-binding protein that catalyses (among other activities) the 5' decapping of Gpp-DNA (formed by homologs of RtcB3 from the bacterium Myxococcus xanthus). The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and eventual release. The enzyme forms a 5'-phospho terminus that can be efficiently joined by ""classical"" ligases. The enzyme also possesses the activitiy of EC 3.1.11.7, adenosine-5'-diphospho-5'-[DNA] diphosphatase and EC 3.1.12.2, DNA-3'-diphospho-5'-guanosine diphosphatase. " +"3.1.12.2","Aprataxin is a DNA-binding protein that catalyses (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8, 3'-phosphate/5'-hydroxy nucleic acid ligase) [1]. The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release. The enzyme also possesses the activity of EC 3.1.11.7, adenosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.1.11.8, guanosine-5'-diphospho-5'-[DNA] diphosphatase." +"3.2.1.200","The enzyme hydrolyses the second glycosidic (1->4) linkage from non-reducing ends of chitin and chitodextrin molecules, liberating N,N'-diacetylchitobiose disaccharides. cf. EC 3.2.1.201, exo-chitinase (reducing end)." +"3.2.1.201","The enzyme hydrolyses the second glycosidic (1->4) linkage from reducing ends of chitin and chitodextrin molecules, liberating N,N'-diacetylchitobiose disaccharides. cf. EC 3.2.1.200, exo-chitinase (non-reducing end)." +"3.2.1.202","The enzyme, characterized from the bacterium Vibrio furnissii, is an endo-cleaving chitodextrinase that participates in the the chitin catabolic pathway found in members of the Vibrionaceae. Unlike EC 3.2.1.14, chitinase, it has no activity on chitin. The smallest substrate is a tetrasaccharide, and the final products are N,N'-diacetylchitobiose and small amounts of N,N',N''-triacetylchitotriose. cf. EC 3.2.1.200, exo-chitinase (non-reducing end), and EC 3.2.1.201, exo-chitinase (reducing end)." +"3.5.1.125","The enzyme, found in bacteria, has no activity with (2S)-4-acetamido-2-aminobutanoate (cf. EC 3.5.4.44, ectoine hydrolase)." +"3.5.1.126",The enzyme has been characterized from the bacterium Klebsiella pneumoniae. +"3.5.1.127","This entry includes a family of enzymes that recyle jasmonoyl-amino acid conjugates back to jasmonates. The enzymes from Arabidopsis thaliana have been shown to also act on 12-hydroxyjasmonoyl-L-isoleucine, generating tuberonic acid." +"3.5.4.44","The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine. The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis. It also produces smaller amounts of (2S)-4-acetamido-2-aminobutanoate, which is recycled back to ectoine by EC 4.2.1.108, ectoine synthase." +"3.5.4.45","The enzyme, isolated from the bacterium Acidovorax citrulli, performs the deamination of melamine 15-fold faster than the deamination of ammeline. It also has activity with 2-chloro-4,6-diamino-s-triazine, but has no activity toward halo-substituted triazine ring compounds such as atrazine (cf. EC 3.8.1.8, atrazine chlorohydrolase)." +"3.5.4.46","Requires Zn2+. The enzyme, isolated from the bacterium Leptospira interrogans, is specific for cAMP." +"4.4.1.35","A pyridoxal 5'-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-thiocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from Brassica oleracea var. italica (broccoli) does not act on cysteine or cystathionine." +"5.1.1.22","The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyses racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position." +"5.1.2.7","The enzyme, present in bacteria, is involved in a degradation pathway of D-galacturonate." +"5.1.3.40",The enzyme from Agrobacterium fabrum C58 is part of D-altritol and galactitol degradation pathways. +"5.4.99.64","The enzyme, characterized from the bacterium Aquincola tertiaricarbonis, uses radical chemistry to rearrange the positions of both a methyl group and a hydroxyl group. It consists of two subunits, the smaller one containing a cobalamin cofactor. It plays a central role in the degradation of assorted substrates containing a tert-butyl moiety." +"6.2.1.48","The enzyme, originally characterized from the bacterium Escherichia coli, can catalyse the transfer of CoA to L-carnitine, crotonobetaine and gamma-butyrobetaine. In vitro the enzyme also exhibits the activity of EC 2.8.3.21, L-carnitine CoA-transferase." +"6.5.1.8","The enzyme is a GTP- and Mn2+-dependent 3'-5' nucleic acid ligase with the ability to join RNA with 3'-phosphate or 2',3'-cyclic-phosphate ends to RNA with 5'-hydroxy ends. It can also join DNA with 3'-phosphate ends to DNA with 5'-hydroxy ends, provided the DNA termini are unpaired [6]. The enzyme is found in members of all three kingdoms of life, and is essential in metazoa for the splicing of intron-containing tRNAs. The reaction follows a three-step mechanism with initial activation of the enzyme by GTP hydrolysis, forming a phosphoramide bond between the guanylate and a histidine residue. The guanylate group is transferred to the 3'-phosphate terminus of the substrate, forming the capped structure [DNA/RNA]-3'-(5'-diphosphoguanosine). When a suitable 5'-OH end is available, the enzyme catalyses an attack of the 5'-OH on the capped end to form a 3'-5' phosphodiester splice junction, releasing the guanylate. When acting on an RNA 2',3'-cyclic-phosphate, the enzyme catalyses an additional reaction, hydrolysing the cyclic phosphate to a 3'-phosphate [9]. The metazoan enzyme requires activating cofactors in order to achieve multiple turnover catalysis [8]." +"1.1.1.408","The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism." +"1.1.1.409","The enzyme, characterized from bacteria, is involved in a pathway for D-erythronate catabolism." +"1.1.1.410","The enzyme, characterized from bacteria, is involved in D-erythronate catabolism." +"1.1.1.411","The enzyme, characterized from bacteria, is involved in L-threonate catabolism." +"1.2.1.99","The enzyme, characterized from the bacterium Escherichia coli, is involved in a putrescine catabolic pathway. It has a broad substrate range, and can also catalyse the activities of EC 1.2.1.19, aminobutyraldehyde dehydrogenase, and EC 1.2.1.24, succinate-semialdehyde dehydrogenase (NAD+)." +"1.2.7.12","Contains a molybdopterin cofactor and numerous [4Fe-4S] clusters. In some organisms an additional subunit enables the incorporation of tungsten when molybdenum availability is low. The enzyme catalyses a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO2 as well as the oxidation of coenzyme M to CO2. The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation." +"1.7.1.16","Contains FMN. The enzyme, characterized from Pseudomonas species, catalyses two successive reductions of nitrobenzene, via a nitrosobenzene intermediate. It is also active on 1-chloro-4-nitrobenzene. " +"1.14.13.235","The enzyme, characterized from Pseudomonas putida strains, catalyses the first step in a pathway for degradation of the plant hormone indole-3-acetate. When acting on indole, the enzyme forms indoxyl, which reacts spontaneously with oxygen to form the blue dye indigo." +"1.14.13.236","This bacterial enzyme belongs to a family of soluble diiron hydroxylases that includes toluene-, benzene-, xylene- and methane monooxygenases, phenol hydroxylases, and alkene epoxidases. The enzyme comprises a four-component complex that includes a hydroxylase, NADH-ferredoxin oxidoreductase, a Rieske-type [2Fe-2S] ferredoxin, and an effector protein." +"1.14.14.44","This cytochrome P-450 (heme-thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucosides (R)-prunasin and (R)-amygdalin. It catalyses three different activities - isomerization of the (E) isomer to the (Z) isomer, dehydration, and C-hydroxylation." +"1.14.14.45","This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of glucosinolates in plants. The enzyme catalyses the N-hydroxylation of aromatic aldoximes derived from L-tryptophan, L-phenylalanine, and L-tyrosine, forming an aci-nitro intermediate that reacts non-enzymically with glutathione to produce an N-alkyl-thiohydroximate adduct, the committed precursor of glucosinolates. In the absence of glutathione, the enzyme is suicidal, probably due to interaction of the reactive aci-nitro compound with catalytic residues in the active site." +"1.14.14.46","A cytochrome P-450 (heme-thiolate) protein. The enzyme catalyses an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl-[acyl-carrier protein], an intermediate in the biosynthesis of biotin. The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal. The mechanism is similar to EC 1.14.15.6, cholesterol monooxygenase (side-chain-cleaving), followed by a hydroxylation step, which may occur spontaneously [2]." +"1.14.14.47","Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC 1.14.13.39)." +"1.14.19.51",A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of the quaternary benzylisoquinoline alkaloid magnoflorine in the plant Coptis japonica. It is specific for (S)-reticuline. +"1.14.99.54","This copper-containing enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner. The cellulose fragments that are formed contain a D-glucono-1,5-lactone residue at the reducing end, which hydrolyses quickly and spontaneously to the aldonic acid. The electrons are provided in vivo by the cytochrome b domain of EC 1.1.99.18, cellobiose dehydrogenase (acceptor) [1]. Ascorbate can serve as the electron donor in vitro." +"1.14.99.55","The enzyme cleaves starch in an oxidative manner. It releases fragments of starch with a D-glucono-1,5-lactone at the reducing end. The initially formed alpha-D-glucono-1,5-lactone at the reducing end of the shortend amylose chain quickly hydrolyses spontaneously to the aldonic acid. In vitro ascorbate has been found to be able to serve as reducing agent. The enzyme contains copper at the active site." +"1.14.99.56","This copper-containing enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner. The cellulose fragments that are formed contain a 4-dehydro-D-glucose residue at the non-reducing end. Some enzymes also oxidize cellulose at the C-1 position of the reducing end forming a D-glucono-1,5-lactone residue [cf. EC 1.14.99.54, lytic cellulose monooxygenase (C1-hydroxylating)]." +"1.14.99.57","The enzyme, characterized from the bacterium Mycobacterium tuberculosis, is involved in heme degradation and iron utilization. The enzyme binds two stacked protoheme molecules per monomer. Unlike the canonical heme oxygenases, the enzyme does not release carbon monoxide or formaldehyde. Instead, it forms unique products, named mycobilins, that retain the alpha-meso-carbon at the ring cleavage site as an aldehyde group. EC 1.6.2.4, NADPH-hemoprotein reductase, can act as electron donor in vitro." +"2.1.1.340","The enzyme, characterized from Hordeum vulgare (barley), catalyses two successive N-methylation reactions during the biosynthesis of gramine, a toxic indole alkaloid." +"2.1.1.341","The enzyme, characterized from the bacterium Sphingomonas sp. SYK6, is involved in the degradation of lignin. The enzyme has similar activities with vanillate and 3-O-methylgallate." +"2.1.1.342","The enzyme, studied from the bacterium Escherichia coli O157:H7, is a radical SAM (AdoMet) enzyme that is involved in heme degradation and iron utilization under anaerobic conditions. The enzyme uses two SAM molecules for the reaction. The first molecule is used to generate a 5'-deoxyadenosyl radical, which abstracts a hydrogen atom from the methyl group of the second SAM molecule. The newly formed methylene radical attacks the substrate, causing a rearrangement of the porphyrin ring that results in the liberation of iron." +"2.3.1.264","The enzyme is found in some methanogenic archaea and bacteria. In archaea it is induced under salt stress. The product, N6-acetyl-beta-L-lysine, serves as a compatible solute, conferring high salt resistance on the producing organisms." +"2.3.3.19","The enzyme, isolated from several Streptomyces species, participate in the biosynthesis of certain phosphonate antibiotics. The enzyme is analogous to EC 2.3.3.1 (Si)-citrate synthase." +"2.4.1.346","Requires Mg2+. The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). " +"2.5.1.140","The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B." +"2.6.1.113","A pyridoxal 5'-phosphate protein. The enzyme, studied in the bacterium Pseudomonas aeruginosa, participates in a putrescine degradation pathway. cf. EC 2.6.1.82, putrescine---2-oxoglutarate aminotransferase." +"2.7.1.217","The enzyme, characterized from bacteria, is involved in D-erythronate and L-threonate catabolism." +"2.8.1.15","The enzyme, found in thermophilic bacteria and archaea, modifies the ribothymidine (5-methyluridine) residue at position 54 of tRNAs. Contains zinc and an [4Fe-4S] cluster. Some organisms, such as the archaeon Pyrococcus horikoshii, do not have a TtuB sulfur-carrier protein, and appear to use sulfide as the sulfur source." +"3.2.1.203","The enzyme from the acidophilic bacterium Alicyclobacillus acidocaldarius is an endo-cleaving hydrolase that cleaves beta(1->4)-linked residues. However, it is specific for (carboxymethyl)cellulose and does not act on cellulosic substrates such as avicel." +"3.5.99.11","The enzyme, characterized from the bacterium Comamonas testosteroni CNB-1, converts 2-aminomuconate to 2-hydroxyhexa-2,4-dienedioate, unlike the enzymes from Pseudomonas, which produce (3E)-2-oxohex-3-enedioate (see EC 3.5.99.5, 2-aminomuconate deaminase). The enzyme also acts on 2-amino-5-chloromuconate." +"3.13.1.5","The enzyme contains Zn2+. The hyperthermophilic archaeon Acidianus sp. A1-3 obtains energy by the conversion of carbon disulfide to hydrogen sulfide, with carbonyl sulfide as an intermediate. " +"4.1.1.104","The enzyme, characterized from bacteria, is involved in D-erythronate and L-threonate catabolism." +"4.1.2.59","The enzyme participates in methanopterin biosynthesis the archaeon Pyrococcus furiosus. The enzyme is specific for 7,8-dihydroneopterin 3'-phosphate. cf. EC 4.1.2.25, dihydroneopterin aldolase and EC 4.1.2.60, dihydroneopterin triphosphate aldolase." +"4.1.2.60","The enzyme, which participates in a pathway for folate biosynthesis, is found in the Stramenopiles, a large group that includes oomycetes, various microalgae and brown algae, as well as in several bacterial phyla. It provides a bypass mechanism compensating for the lack of EC 4.1.2.25, dihydroneopterin aldolase. In the malaria parasite Plasmodium falciparum the enzyme is bifunctional and also catalyses the activity of EC 4.2.3.12, 6-pyruvoyltetrahydropterin synthase. cf. EC 4.1.2.59, dihydroneopterin phosphate aldolase." +"4.99.1.10","Inhibited by Ca2+, Mg2+ and especially Hg2+. SGR has very low activity with chlorophyllide a and none with chlorophyll b. It acts on chlorophyll a both in its free form and in protein complex. SGRL, on the other hand, is more active with chlorophyllide a than with chlorophyll a. The magnesium formed is scavenged by MCS (metal-chelating substance)." +"4.99.1.11","The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin." +"5.1.3.41","The enzyme, characterized from the bacterium Escherichia coli, is involved in the catabolism of fructoseamines, amino acid sugar complexes that are formed non-enzymically." +"5.3.1.35","The enzyme, characterized from bacteria, is involved in D-erythronate and L-threonate catabolism." +"6.2.1.49","The enzyme, found in certain mycobacteria, activates long-chain fatty acids by adenylation and transfers them to EC 2.3.1.111, mycocerosate synthase. The enzyme participates in the biosynthesis of the virulent lipids dimycocerosates (DIM) and dimycocerosyl triglycosyl phenolphthiocerol (PGL)." +"6.3.2.50","This fungal enzyme, isolated from Magnaporthe oryzae, is an non-ribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) hybrid protein that consists of condensation (C), adenylation (A) and peptidyl-carrier protein (PCP) domains in the NRPS portion and a ketosynthase (KS) domain in the PKS portion. ATP is required for activation of isoleucine, which is then condensed with acetoacetyl-CoA. Cyclization and release from the enzyme are catalysed by the KS domain." +"6.3.2.51","A key enzyme in the production of coenzyme A. The eukaryotic enzyme requires ATP, in contrast to the bacterial enzyme, EC 6.3.2.5, phosphopantothenate---cysteine ligase (CTP), which requires CTP." +"6.3.3.7","The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase." +"6.3.5.12","The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase." +"6.4.1.9","The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase." +"1.1.1.413","The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration." +"1.1.99.41","This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle). In vivo, it functions in the direction of reduction. It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates." +"1.5.5.3","A flavoprotein (FAD). The enzyme from human also has low activity with L-proline (cf. EC 1.5.5.2, proline dehydrogenase)." +"1.5.98.3","The enzyme, found in some methanogenic archaea, is responsible for the reoxidation of coenzyme F420, which is reduced during methanogenesis, and for the reduction of methanophenazine to dihydromethanophenazine, which is required by EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase. The enzyme is membrane-bound, and is coupled to proton translocation across the cytoplasmic membrane, generating a proton motive force that is used for ATP generation." +"1.8.1.20","The enzyme, characterized from the bacterium Rhodococcus erythropolis MI2, contains an FMN cofator." +"1.8.3.7","Requires a copper cofactor and Ca2+. The enzyme, which is found in both prokaryotes and eukaryotes, catalyses a modification of a conserved L-cysteine residue in the active site of sulfatases, generating a unique 3-oxo-L-alanine residue that is essential for sulfatase activity. The exact nature of the thiol involved is still not clear - dithiothreitol and cysteamine are the most efficiently used thiols in vitro. Glutathione alo acts in vitro, but it is not known whether it is used in vivo. " +"1.13.11.83","Requires non-heme-iron(II). Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.12.23, 4-hydroxy-3-prenylbenzoate synthase." +"1.13.12.23","Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.11.83, 4-hydroxy-3-prenylphenylpyruvate oxygenase." +"1.14.13.237","The enzyme is a member of the flavin-dependent monooxygenase (FMO) family (cf. EC 1.14.13.8). The plant Arabidopsis thaliana contains five isoforms. GS-OX1 through GS-OX4 are able to catalyse the S-oxygenation independent of chain length, while GS-OX5 is specific for 8-(methylsulfanyl)octyl glucosinolate." +"1.14.13.238","The enzyme, characterized from several bacterial species, is involved in a pathway for the degradation of methylated amines. It is composed of three subunits, one of which is a ferredoxin, and contains heme iron and an FMN cofactor." +"1.14.14.48","A cytochrome P450 (heme thiolate) enzyme found in plants. The enzyme acts on jasmonoyl-L-amino acid conjugates, catalysing the hydroxylation of the C-12 position of jasmonic acid. While the best studied substrate is (+)-7-epi-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-valine and jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates." +"1.14.14.49","A cytochrome P450 (heme thiolate) enzyme found in plants. The enzyme acts on jasmonoyl-L-amino acid conjugates that have been hydroxylated at the C-12 position of jasmonic acid by EC 1.14.14.48, jasmonoyl-L-amino acid 12-hydroxylase, further oxidizing that position to a carboxylate via an aldehyde intermediate. While the best studied substrate is (+)-7-epi-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates." +"1.14.14.50","This cytochrome P-450 (heme thiolate) enzyme acts on 16-methoxytabersonine, leading to biosynthesis of vindoline in the plant Catharanthus roseus (Madagascar periwinkle). It can also act on tabersonine, resulting in the production of small amounts of vindorosine. The products are unstable and, in the absence of EC 1.1.99.41, 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase, will convert into 3-epoxylated compounds." +"1.14.14.51","A cytochrome P-450 (heme thiolate) enzyme. The enzyme participates in the biosynthesis of (-)-carvone, which is responsible for the aroma of spearmint." +"1.14.14.52","A cytochrome P-450 (heme thiolate) enzyme. The enzyme, characterized from the plant Perilla frutescens, participates in the biosynthesis of perillyl aldehyde, the major constituent of the essential oil that accumulates in the glandular trichomes of this plant. Some forms of the enzyme also catalyse the oxidation of (-)-perillyl alcohol to (-)-perillyl aldehyde." +"1.14.14.53","The reaction is stereospecific with over 95% yield of (+)-trans-carveol from (R)-limonene. (S)-Limonene, the substrate for EC 1.14.14.51, (S)-limonene 6-monooxygenase, is not a substrate. Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds." +"1.14.14.54","This cytochrome P-450 (heme-thiolate) enzyme, found in Aspergillus nidulans, is involved in the degradation of phenylacetate." +"1.14.15.23","The enzyme, characterized from the bacterium Sphingomonas sp. DC-6, initiates the degradation of several chloroacetanilide herbicides, including alachlor, acetochlor, and butachlor. The enzyme is a Rieske non-heme iron oxygenase, and requires a ferredoxin and EC 1.18.1.3, ferredoxin---NAD+ reductase, for activity." +"1.14.18.9","This enzyme is found in fungi and animals and catalyses a step in the biosynthesis of important sterol molecules such as ergosterol and cholesterol, respectively. The enzyme acts on the 4alpha-methyl group. Subsequent decarboxylation by EC 1.1.1.170, 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), occurs concomitantly with epimerization of the remaining 4beta-methyl into the 4alpha position, thus making it a suitable substrate for a second round of catalysis. cf. EC 1.14.13.246, 4beta-methylsterol monooxygenase; EC 1.14.18.10, plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase; and EC 1.14.18.11, plant 4alpha-monomethylsterol monooxygenase." +"1.14.19.52","This cytochrome P-450 (heme thiolate) enzyme, which has been characterized from the plant Arabidopsis thaliana, catalyses the last two steps in the biosynthesis of camalexin, the main phytoalexin in that plant. The enzyme catalyses two successive oxidation events. During the first oxidation the enzyme introduces a C-N double bond, liberating hydrogen cyanide, and during the second oxidation it catalyses a decarboxylation." +"1.14.99.58","The enzyme, characterized from the bacterium Pseudomonas aeruginosa, differs from EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin), in that the heme substrate is rotated by approximately 110 degrees within the active site, resulting in cleavage at a different part of the ring. It forms a mixture of about 70% biliverdin-IX-delta and 30% biliverdin-IX-beta." +"1.16.3.3","The enzyme, which belongs to the multicopper oxidase family, is found in many bacterial strains. It oxidizes soluble manganese(II) to insoluble manganese(IV) oxides. Since the enzyme is localized to the outer surface of the cell, its activity usually results in encrustation of the cells by the oxides. The physiological function of bacterial manganese(II) oxidation remains unclear." +"1.17.1.9","The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase." +"1.17.1.10",A tungsten-selenium-iron protein characterized from the bacterium Moorella thermoacetica. It is extremely sensitive to oxygen. +"1.17.1.11","The enzyme complex, isolated from the bacterium Gottschalkia acidurici, couples the reduction of NAD+ and the reduction of ferredoxin with formate via flavin-based electron bifurcation. " +"1.17.2.3","The enzyme has been characterized from the bacterium Desulfovibrio vulgaris. In vitro, yeast cytochrome c, ferricyanide and phenazine methosulfate can act as acceptors." +"1.17.5.3","The enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups. Formate dehydrogenase-N oxidizes formate in the periplasm, transferring electrons via the menaquinone pool in the cytoplasmic membrane to a dissimilatory nitrate reductase (EC 1.7.5.1), which transfers electrons to nitrate in the cytoplasm. The system generates proton motive force under anaerobic conditions [3]." +"1.17.98.3","The enzyme, characterized from methanogenic archaea, is involved in formate-dependent H2 production. It contains noncovalently bound FAD [1]. " +"1.17.99.7","Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1]." +"2.1.1.343","The enzyme, characterized from the soil bacterium Streptomyces davawensis, catalyses the last two steps in the biosynthesis of the antibiotic roseoflavin." +"2.1.1.344","The enzyme, characterized from the bacterium Singulisphaera acidiphila, catalyses three successive methylations of the terminal delta-nitrogen in ornithine lipids." +"2.3.1.265","The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs)." +"2.3.2.30","The enzyme, found in bacteria, catalyses the first step in the biosynthesis of ornithine lipids." +"2.4.1.347","The enzyme has been reported from the yeast Saccharomyces cerevisiae and from mycobacteria. The enzyme from Mycobacterium tuberculosis can also use UDP-alpha-D-glucose, but the activity with ADP-alpha-D-glucose, which is considered the main substrate in vivo, is higher." +"2.5.1.141","The enzyme, found in many archaea, bacteria, and eukaryotes, produces heme o, which in many cases is further modified into heme a. In organisms that produce heme a, the enzyme forms a complex with heme a synthase. In some archaeal species the enzyme transfers a geranylgeranyl group instead of a farnesyl group." +"2.7.1.218","The enzyme, characterized from the bacterium Escherichia coli, has very little activity with fructose." +"2.7.1.219","The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism." +"2.7.1.220","The enzyme, characterized from bacteria, is involved in a pathway for D-erythronate catabolism." +"2.7.1.221","The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway." +"2.7.7.99","The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway." +"2.8.2.38","The enzyme catalyses the last step in the biosynthesis of aliphatic glucosinolate core structures. cf. EC 2.8.2.24, aromatic desulfoglucosinolate sulfotransferase." +"2.8.2.39","The enzyme, charaterized from the plant Arabidopsis thaliana, also acts on 11-hydroxyjasmonate." +"3.1.3.105","The enzyme, characterized from Pseudomonas species, participates in a peptidoglycan salvage pathway." +"3.1.4.58","The enzyme hydrolyses RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. In vitro the enzyme can also ligate tRNA molecules with 2',3'-cyclic phosphate to tRNA with 5'-hydroxyl termini, forming a 2'-5' phosphodiester linkage. However, the ligase activity is unlikely to be relevant in vivo." +"3.1.7.12",Isolated from the bacterium Herpetosiphon aurantiacus. +"3.2.1.204","The enzyme, characterized from the bacteria Bacillus sp. NRRL B-21195 and Kribbella flavida, participates in the degradation of starch. The cyclic tetrasaccharide cyclobis-(1->6)-alpha-nigerosyl is formed from starch extracellularly and imported into the cell, where it is degraded to glucose." +"3.2.1.205","The enzyme catalyses the hydrolysis of alpha-1,6-glucosidic linkages from the non-reducing end of its substrate. Unlike EC 3.2.1.10, oligo-1,6-glucosidase, the enzyme inverts the anomeric configuration of the released residue. The enzyme can also act on panose and maltotriose at a lower rate." +"3.4.19.16","This enzyme, characterized from the plant Arabidopsis thaliana, participates in the biosynthesis of the plant defense compounds glucosinolates and camalexin. It is the only known plant enzyme capable of hydrolysing the gamma-glutamyl residue of glutathione in the cytosol." +"3.13.1.6","Requires Zn2+. The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in an L-cysteine biosynthesis pathway. It acts on the product of EC 2.5.1.113, [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase." +"4.2.1.172",The enzyme has been characterized from the bacterium Peptoclostridium difficile. The active form contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster. +"4.2.1.173",Isolated from the plant Salvia miltiorrhiza (red sage). +"4.2.1.174",Isolated from the plant Marrubium vulgare (white horehound). Involved in marrubiin biosynthesis. +"4.2.3.157",(+)-Isoafricanol is a sesquiterpene alcohol. Its synthesis has been shown to occur in the bacteria Streptomyces violaceusniger and Streptomyces malaysiensis. +"4.2.3.158","The enzyme, which forms the diterpene (-)-spiroviolene, has been characterized from the bacterium Streptomyces violens." +"4.2.3.159",The synthesis of the diterpene tsukubadiene has been shown to occur in the Actinobacterium Streptomyces tsukubaensis. +"4.2.3.160","The enzyme has been described from the slime-mould Dictyostelium discoideum. It is specific for (2E,6E)-farnesyl diphosphate. While the major product is the sequiterpene (2S,3R,6S,9S)-(-)-protoillud-7-ene, traces of pentalenene are also formed." +"4.2.3.161","The sequiterpene (3S)-(+)-asterisca-2(9),6-diene has been shown to be synthezised in the slime-mould Dictyostelium discoideum. The enzyme is specific for (2E,6E)-farnesyl diphosphate." +"4.2.3.162","The enzyme, found in the bacterium Streptomyces viridochromogenes, is specific for (2E,6E)-farnesyl diphosphate and produces only (-)-alpha-amorphene." +"4.2.3.163","The enzyme, which forms the sesquiterpene (+)-corvol ether B, has been reported from the bacterium Kitasatospora setae." +"4.2.3.164",The enzyme has been identified in the myxobacterium Sorangium cellulosum and in the fungus Fusarium fujikuroi. +"4.2.3.165","The original enzyme (STC5) from the fungus Fusarium fujikuroi is inactive because of a critically naturally occuring mutation that leads to an asparagine to lysine exchange in the NSE (Asn-Ser-Glu) triad, a highly conserved motif of type I terpene cyclases. Sequence correction by site-directed mutagenesis (K288N) restores activity." +"4.2.3.166","The enzyme has been identified in the bacterium Streptomyces pratensis. It is specific for (2E,6E)-farnesyl diphosphate." +"4.2.3.167","Isolated from an ecotype of the plant Arabidopsis thaliana from Cape Verde Islands. The enzyme also gives (3E,7E)-dolathalia-3,7,11-triene and traces of other terpenoids. cf. EC 4.2.3.168 dolathalia-3,7,11-triene synthase." +"4.2.3.168","Isolated from an ecotype of the plant Arabidopsis thaliana from Cape Verde Islands. The enzyme also gives (3E,7E)-dolabella-3,7-dien-18-ol and traces of other terpenoids. cf. EC 4.2.3.167 dolabella-3,7-dien-18-ol synthase." +"4.2.3.169","The enzyme, found in the bacterium Streptomyces viridochromogenes, is specific for (2E,6E)-farnesyl diphosphate." +"4.2.3.170","The enzyme, found in the bacterium Streptosporangium roseum, is specific for (2E,6E)-farnesyl diphosphate. " +"4.2.3.171","The enzyme, which forms the sesquiterpene (+)-corvol ether A, has been reported from the bacterium Kitasatospora setae." +"4.2.3.172","Isolated from the plant Inula hupehensis. The enzyme also gives gives tau-cadinol and traces of other terpenoids, see EC 4.2.3.173, tau-cadinol synthase." +"4.2.3.173","Isolated from the plant Inula hupehensis. The enzyme also gives 10-epi-juneol and traces of other terpenoids, see EC 4.2.3.172, 10-epi-juneol synthase. It has also been isolated from the plants maize (Zea mays) and lavender (Lavandula angustifolia)." +"4.2.3.174","Isolated from the plant Camellia brevistyla. See also EC 4.2.3.187, (2Z,6E)-hedycaryol synthase." +"4.2.3.175","Isolated from the bacterium Sorangium cellulosum So ce56. The enzyme is also responsible for the formation of trace amounts of many other sesquiterpenes, mainly cadinanes and cubebanes." +"4.2.3.176",Isolated from the fungus Neosartorya fischeri. +"4.2.3.177","Isolated from the plant Cananga odorata var. fruticosa (ylang ylang). The enzyme forms roughly equal proportions of beta-thujene, sabinene, beta-pinene and alpha-terpinene see EC 4.2.3.109/EC 4.2.3.110 sabinene synthase, EC 4.2.3.120/EC 4.2.3.122 beta-pinene synthase, EC 4.2.3.115 alpha-terpinene synthase." +"4.2.3.178",Isolated from the fungus Aspergillus stellatus. +"4.2.3.179",Isolated from the plant Xanthium strumarium (rough cocklebur). +"4.2.3.180","Isolated from the plant Pseudolarix amabilis (golden larch). The product is oxidized to pseudolaric acid B, a microtubule-destabilizing agent. " +"4.2.3.181",Isolated from the bacteria Streptomyces pristinaespiralis and S. somaliensis. +"4.2.3.182",Isolated from the bacterium Streptomyces pristinaespiralis. +"4.2.3.183",Isolated from the plant Isodon rubescens. +"4.2.3.184",Isolated from the liverwort Marchantia polymorpha. +"4.2.3.185",Isolated from the plant Isodon rubescens and several species of Aconitum as well as species of Streptomyces. +"4.2.3.186",Isolated from the plant Salvia miltiorrhiza (red sage). +"4.2.3.187","Isolated from the bacterium Kitasatospora setae. The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. See also EC 4.2.3.174 (2E,6E)-hedycaryol synthase." +"4.2.3.188",Isolated from the bacterium Bacillus clausii. The enzyme acts on a range of polyprenyl diphosphates. +"4.2.3.189",Isolated from the plants Marrubium vulgare (white horehound) and Vitex agnus-castus (chaste tree). Involved in marrubiin biosynthesis. +"4.2.3.190","Manoyl oxide is found in many plants. This enzyme has been isolated from the plants, Grindelia hirsutula (gum weed), Plectranthus barbatus (forskohlii) and Marrubium vulgare (white horehound)." +"4.2.3.191",Isolated from the fungus Sordaria araneosa. Cycloaraneosene is a precursor of the antibiotic sordarin. +"4.2.3.192",Isolated from the bacterium Streptomyces clavuligerus. +"4.2.3.193",Isolated from the bacterium Streptomyces cyslabdanicus. +"4.2.3.194",Isolated from the plants Valeriana officinalis (valerian) and Persicaria hydropiper (water pepper). The enzyme does not act on farnesol or drimenol diphosphate. Using 18-oxygen labelled water 18-oxygen was incorporated suggesting involvement of a stabilised carbocation or an equivalent species. +"4.3.2.7","The enzyme, found in bacteria, fungi and animals, is specific for glutathione (cf. EC 4.3.2.9, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline." +"4.3.2.8","The enzyme, found in vertebrates, has no activity toward alpha-(gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline." +"4.3.2.9","The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline." +"4.4.1.36","Contains pyridoxal 5'-phosphate. The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-(hydroxysulfanyl)hercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function." +"5.4.4.8","Isolated from the bacterium Thauera linaloolentis grown on (RS)-linalool as the sole source of carbon. Unlike EC 5.4.4.4, geraniol isomerase, which only acts on (S)-linalool, this enzyme acts equally well on both enantiomers." +"5.4.99.65","Isolated from the plant Lycopodium clavatum. The enzyme does not act on (3S)-2,3-epoxy-2,3-dihydrosqualene and does not form any alpha-onocerin." +"5.4.99.66",Isolated from the plant Lycopodium clavatum. +"5.5.1.28",Isolated from the hallucinogenic plant Salvia divinorum (seer's sage) and the medicinal plant Tripterygium wilfordii (thunder god vine). +"5.5.1.29",Isolated from the bacterium Herpetosiphon aurantiacus. +"5.5.1.30",Isolated from the bacterium Streptomyces clavuligerus. +"6.1.3.1","The enzyme, found in certain bacterial species, participates in a pathway for the production of olefins. It forms a beta-lactone. The alkyl group at C2 of the substrate ends up as the 3-alkyl group of the product." +"6.2.1.50","This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase." +"1.2.99.10",The enzyme has been described from the bacteria Methylomonas sp. 16a and Bacillus indicus. +"1.3.1.113","The enzyme, characterized from the bacteria Streptomyces griseus and Streptomyces coelicolor, is involved in the biosynthesis of gamma-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria." +"1.3.8.14","Contains FAD. The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It is believed to catalyse the formation of a Delta2-pyrrolin-2-carbonyl-[peptidyl-carrier protein] intermediate, followed by a two-electron oxidation to 1H-pyrrol-2-carbonyl-[peptidyl-carrier protein]." +"1.8.5.8","Contains FAD. This eukaryotic enzyme, located at the inner mitochondrial membrane, catalyses the first step in the metabolism of sulfide. While both sulfite and glutathione have been shown to act as sulfane sulfur acceptors in vitro, it is thought that the latter acts as the main acceptor in vivo. The electrons are transferred via FAD and quinones to the electron transfer chain. Unlike the bacterial homolog (EC 1.8.5.4, bacterial sulfide:quinone reductase), which repeats the catalytic cycle without releasing the product, producing a polysulfide, the eukaryotic enzyme transfers the persulfide to an acceptor at the end of each catalytic cycle." +"1.8.7.3","HdrABC is an enzyme complex that is found in most methanogens and catalyses the reduction of the CoB-CoM heterodisulfide back to CoB and CoM. HdrA contains a FAD cofactor that acts as the entry point for electrons, which are transferred via HdrC to the HdrB catalytic subunit. One form of the enzyme from Methanosarcina acetivorans (HdrA2B2C2) can also catalyse EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase." +"1.8.98.4","The enzyme, characterized from the archaeon Methanosarcina acetivorans, catalyses the reduction of CoB-CoM heterodisulfide back to CoB and CoM. The enzyme consists of three components, HdrA, HdrB and HdrC, all of which contain [4Fe-4S] clusters. Electrons enter at HdrA, which also contains FAD, and are transferred via HdrC to the catalytic component, HdrB. During methanogenesis from acetate the enzyme catalyses the activity of EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase. However, it can also use electron bifurcation to direct electron pairs from reduced coenzyme F420 towards the reduction of both ferredoxin and CoB-CoM heterodisulfide. This activity is proposed to take place during Fe(III)-dependent anaerobic methane oxidation. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase." +"1.8.98.5","This enzyme complex is found in H2-oxidizing CO2-reducing methanogenic archaea such as Methanothermobacter thermautotrophicus. It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD hydrogenase. Electron pairs donated by the hydrogenase are transferred via its delta subunit to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. The reductase can also form a similar complex with formate dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase." +"1.8.98.6","The enzyme is found in formate-oxidizing CO2-reducing methanogenic archaea such as Methanococcus maripaludis. It consists of a cytoplasmic complex of HdrABC reductase and formate dehydrogenase. Electron pairs donated by formate dehydrogenase are transferred to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. cf. EC 1.8.7.3, ferredoxin:CoB-CoM heterodisulfide reductase, EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase." +"1.13.11.84","The enzyme, characterized from the plant Crocus sativus (saffron), acts twice, cleaving 3beta-hydroxy-beta-cyclocitral off each 3-hydroxy end group. It is part of the zeaxanthin degradation pathway in that plant, leading to the different compounds that impart the color, flavor and aroma of the saffron spice. The enzyme can similarly cleave the 7-8 double bond of other carotenoids with a 3-hydroxy-beta-carotenoid end group." +"1.14.13.239","The bacterial enzyme is a complex consisting of a reductase and an oxygenase components. The reductase subunit contains a flavin and a plant-type ferredoxin [2Fe-2S] cluster, while the oxygenase subunit has two domains, a Rieske-type protein in which a [2Fe-2S] cluster is coordinated by two histidine and two cysteine residues, and a domain with a catalytic mononuclear iron centre [4]." +"1.14.14.55",A cytochrome P-450 (heme-thiolate) protein. +"1.14.14.56","A cytochrome P-450 (heme-thiolate) protein. The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.14.55, quinine 3-monooxygenase, EC 1.14.14.57, taurochenodeoxycholate 6-hydroxylase and EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming)." +"1.14.15.24",Requires ferredoxin and iron(II). Also acts on other carotenoids with a beta-end group. In some species canthaxanthin is the preferred substrate. +"1.14.99.59",A cytochrome P-450 (heme-thiolate) protein isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin. +"2.1.1.345","Isolated from the fungus Psilocybe cubensis. The product, psilocybin, is a psychoactive compound." +"2.1.3.15","The enzyme catalyses the transfer of a carboxyl group carried on a biotinylated biotin carboxyl carrier protein (BCCP) to acetyl-CoA, forming malonyl-CoA. In some organisms this activity is part of a multi-domain polypeptide that includes the carrier protein and EC 6.3.4.14, biotin carboxylase (see EC 6.4.1.2, acetyl-CoA carboxylase). Some enzymes can also carboxylate propanonyl-CoA and butanoyl-CoA (cf. EC 6.4.1.3, propionyl-CoA carboxylase)." +"2.3.2.31","RBR-type E3 ubiquitin transferases have two RING fingers separated by an internal motif (IBR, for In Between RING). The enzyme interacts with the CRL (Cullin-RING ubiquitin Ligase) complexes formed by certain RING-type E3 ubiquitin transferase (see EC 2.3.2.27), which include a neddylated cullin scaffold protein and a substrate recognition module. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue in the RING2 domain, followed by the transfer of the ubiquitin from RING2 to the substrate [4]. Once the substrate has been ubiquitylated by the RBR-type ligase, it can be ubiqutylated further using ubiquitin carried directly on E2 enzymes, in a reaction catalysed by EC 2.3.2.27. Activity of the RBR-type enzyme is dependent on neddylation of the cullin protein in the CRL complex [2,4]. cf. EC 2.3.2.26, HECT-type E3 ubiquitin transferase, EC 2.3.2.27, RING-type E3 ubiquitin transferase, and EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase." +"2.3.2.32","Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form a complex with a cullin scaffold protein and a substrate recognition module, which is named CRL for Cullin-RING-Ligase. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. The transfer of NEDD8 from a NEDD8-specific E2 enzyme onto the cullin protein is a secondary function of the RING-type E3 ubiquitin transferase in the CRL complex. The process requires auxiliary factors that belong to the DCN1 (defective in cullin neddylation 1) family." +"2.4.1.348","The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a." +"2.4.1.349","The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a. It has no activity with N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.4.1.348, N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase)." +"2.4.1.350",Isolated from the plant Siraitia grosvenorii (monk fruit). +"2.5.1.142",Isolated from the plant Solanum lycopersicum (tomato). +"2.7.1.222",Also acts on 4-hydroxy-L-tryptophan in vitro. Isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin. +"2.7.3.13","The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides." +"3.2.1.206",Oleuropein is a glycosylated secoiridoid exclusively biosynthesized by members of the Oleaceae plant family where it is part of a defence system againt herbivores. The enzyme also hydrolyses ligstroside and demethyloleuropein. +"4.1.1.105","The enzyme has been characterized from bacteria, plants, and fungi. Unlike EC 4.1.1.28, aromatic-L-amino-acid decarboxylase, this enzyme is specific for L-tryptophan." +"4.1.1.106","This algal enzyme, characterized from the green algae Chlorella variabilis and Chlamydomonas reinhardtii, is dependent on blue light, which photooxidizes its FAD cofactor. The enzyme acts on fatty acids in the range of C12 to C22, with a higher efficiency for C16 to C17 chains, and forms an alkane product that is one carbon shorter than the substrate. The enzyme can also act on unsaturated fatty acids, forming the respective alkenes, but does not generate a new double bond." +"4.1.1.107","A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha-methyl-L-dopa." +"4.1.1.108","A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plant Petroselinum crispum (parsley), catalyses the production of 4-hydroxyphenylacetaldehyde directly from L-tyrosine. Tyramine is not formed as an intermediate. The enzyme has a low activity with L-dopa (cf. EC 4.1.1.107, 3,4-dihydroxyphenylacetaldehyde synthase)." +"4.1.1.109","A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plants Petunia hybrida and a Rosa hybrid, catalyses the production of phenylacetaldehyde directly from L-phenylalanine. The enzyme is specific for L-phenylalanine and does not accept other aromatic amino acids as substrates." +"4.1.99.23","The enzyme, purified from bacteria, is part of the anaerobic pathway for cobalamin biosynthesis. It binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate." +"4.2.3.195",The enzyme was identified in the roots of the plant Arabidopsis thaliana (thale cress). The product is a semivolatile diterpene that acts as a local antifeedant in belowground direct defense against root-feeding insects. +"4.99.1.12","This enzyme, found in Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It catalyses the insertion of Ni2+ into the cofactor forming a covalent bond between a carbon atom and the nickel atom." +"6.2.1.51","The mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to the phenolphthiocerol/phthiocerol polyketide synthase." +"6.2.1.52","This is an alternative activity of the firefly luciferase (EC 1.13.12.7), which the enzyme exhibits under normal conditions only when acting on the L-enantiomer of its substrate. The D-isomer can act as a substrate for the CoA---ligase activity in vitro only under low oxygen conditions that are not found in vivo. The activation of L-firefly luciferin to a CoA ester is a step in a recycling pathway that results in its epimerization to the D enantiomer, which is the only substrate whose oxygenation results in light emission." +"1.8.2.6","The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. The enzyme from the bacterium Paracoccus pantotrophus contains a molybdoprotein component and a diheme c-type cytochrome component. The enzyme successively oxidizes the outer sulfur atom in [SoxY protein]-S-disulfanyl-L-cysteine, using three water molecules and forming [SoxY protein]-S-sulfosulfanyl-L-cysteine. During the process, six electrons are transferred to the electron chain via cytochrome c." +"1.13.12.24","Ca2+-regulated photoproteins are found in a variety of bioluminescent marine organisms, mostly coelenterates, and are responsible for their light emission. The best studied enzyme is from the jellyfish Aequorea victoria. The enzyme tightly binds the imidazolopyrazinone derivative coelenterazine, which is then peroxidized by oxygen. The hydroperoxide is stably bound until three Ca2+ ions bind to the protein, inducing a structural change that results in the formation of a 1,2-dioxetan-3-one ring, followed by decarboxylation and generation of a protein-bound coelenteramide in an excited state. The calcium-bound protein-product complex is known as a blue fluorescent protein. In vivo the energy is transferred to a green fluorescent protein (GFP) by Forster resonance energy transfer. In vitro, in the absence of GFP, coelenteramide emits a photon of blue light while returning to its ground state." +"1.14.11.58","The enzyme, characterized from the bacterium Rhizobium tropici, catalyses the hydroxylation of C-2 of the fatty acyl group that is ester-linked to the 3-hydroxy position of the amide-linked fatty acid." +"1.14.11.59","The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses)." +"1.14.14.57","A cytochrome P-450 (heme-thiolate) protein. Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid [5]." +"1.14.14.58","A cytochrome P-450 (heme-thiolate) protein isolated from the plants Arabidopsis thaliana (thale cress) and Zea mays (maize). It forms this C16 homoterpene in response to herbivore attack. In vitro some variants of the enzyme also convert (3S,6E)-nerolidol to (3E)-4,8-dimethylnona-1,3,7-triene (see EC 1.14.14.59, dimethylnonatriene synthase)." +"1.14.14.59","A cytochrome P-450 (heme-thiolate) protein isolated from the plants Arabidopsis thaliana (thale cress) and Zea mays (maize). It forms this C11 homoterpene in response to herbivore attack. In vitro the enzyme also converts (6E,10E)-geranyllinalool to (3E,7E)-4,8,12-trimethyltrideca-1,3,7,11-tetraene (see EC 1.14.14.58, trimethyltridecatetraene synthase)." +"1.14.14.60","A cytochrome P-450 (heme-thiolate) protein isolated from the plants Salvia pomifera (apple sage) and Salvia miltiorrhiza (danshen). 11-Hydroxyferruginol is a precursor of carnosic acid, a potent antioxidant." +"1.14.14.61","A cytochrome P-450 (heme-thiolate) protein isolated from the plants Salvia pomifera (apple sage), S. miltiorrhiza (red sage), S. fruticosa (Greek sage) and Rosmarinus officinalis (Rosemary)." +"1.14.14.62",A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia pomifera (apple sage). +"1.14.14.63",A cytochrome P-450 (heme-thiolate) protein isolated from the plant Platycodon grandiflorus (baloon flower). The enzyme is also able to oxidize oleanolic acid to cochalic acid. +"1.14.14.64",A cytochrome P-450 (heme-thiolate) protein isolated from the plant Solanum lycopersicum (tomato). +"1.14.14.65",A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11-hydroxysugiol. It also oxidizes at C-12 of ferruginol (EC 1.14.14.60 ferruginol monooxygenase). +"1.14.14.66","A P-450 monoxygenase involved in psoralen biosynthesis, see EC 1.14.14.141, psoralen synthase." +"1.14.14.67","A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11,20-dihydroxyferruginol." +"1.14.14.68","A cytochrome P-450 (heme-thiolate) protein isolated from rice, Oryza sativa." +"1.14.14.69","A cytochrome P-450 (heme-thiolate) protein isolated from the plant Oryza sativa (rice) that is involved in phytocassanes biosynthesis. Depending on the order of activities, the enzyme may form either ent-cassa-12,15-dien-2-one or ent-cassa-12,15-diene-2beta,3beta-diol as an intermediate." +"1.14.15.25","The enzyme, characterized from several Pseudomonas strains, initiates p-cymene catabolism through hydroxylation of the methyl group. The enzyme has a distinct preference for substrates containing at least an alkyl or heteroatom substituent at the para-position of toluene. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. In Pseudomonas chlororaphis the presence of a third component of unknown function greatly increases the activity. cf. EC 1.14.15.26, toluene methyl-monooxygenase." +"1.14.15.26","The enzyme, characterized from several Pseudomonas strains, catalyses the first step in the degradation of toluenes and xylenes. It has a broad substrate specificity and is also active with substituted compounds, such as chlorotoluenes. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. The enzyme can also act on its products, producing gem-diols that spontaneously dehydrate to form aldehydes." +"1.14.19.53",A cytochrome P-450 (heme thiolate) enzyme found in vertebrates. The enzyme is also active with retinal and retinoic acid. +"2.1.1.346","This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions [2]. " +"2.1.1.347",Isolated from the bacterium Herpetosiphon aurantiacus. +"2.1.5.1","This enzyme was characterized from the bacterium Sinomonas sp. No.22. It catalyses a cleavage of a methylene bridge, followed by the transfer of the methylene group to tetrahydrofolate. The enzyme is also active with (+)-episesamin, (-)-asarinin, (+)-sesaminol, (+)-sesamolin, and piperine." +"2.3.1.266","The enzyme, characterized from bacteria, is specific for protein bS18, a component of the 30S ribosomal subunit. cf. EC 2.3.1.267, [ribosomal protein uS5]-alanine N-acetyltransferase." +"2.3.1.267","The enzyme, characterized from bacteria, is specific for protein uS5, a component of the 30S ribosomal subunit. It also plays a role in maturation of the 30S ribosomal subunit. cf. EC 2.3.1.266, [ribosomal protein bS18]-alanine N-acetyltransferase." +"2.3.1.268","The enzyme, characterized from the yeast Wickerhamomyces anomalus, is responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts. It is only distantly related to enzymes classified as EC 2.3.1.84, alcohol O-acetyltransferase. The enzyme also possesses thioesterase and esterase activities, which are inhibited by high ethanol concentrations." +"2.3.3.20","The enzyme, found in certain bacterial species, catalyses a head-to-head non-decarboxylative Claisen condensation of two acyl-CoA molecules, resulting in formation of a 2-alkyl-3-oxoalkanoic acid. It is part of a pathway for the production of olefins." +"2.4.1.351","The enzyme, characterized from Vigna angularis (azuki beans), participates in the biosynthesis of rhamnogalacturonan type I. It does not require any metal ions, and prefers substrates with a degree of polymerization larger than 7." +"2.4.1.352",The enzyme has been characterized from the bacterium Meiothermus silvanus. +"2.6.1.114","The enzyme, characterized from the bacterium Streptomyces davawensis, has the activities of an oxidoreductase, a decarboxylase, and an aminotransferase. Its combined actions result in the replacement of a methyl substituent of one of the aromatic rings of FMN by an amino group, a step in the biosynthetic pathway of roseoflavin. The reaction requires thiamine for completion." +"2.7.9.6","The enzyme, characterized from a diverse collection of Gram-positive bacteria, inactivates the antibiotic rifampicin by phosphorylating it at position 21. The enzyme comprises three domains: two substrate-binding domains (ATP-grasp and rifampicin-binding domains) and a smaller phosphate-carrying L-histidine swivel domain that transits between the spatially distinct substrate-binding sites during catalysis." +"3.1.1.103","The enzyme, characterized from the bacterium Staphylococcus aureus, removes D-alanine groups from the teichoic acid produced by this organism, thus modulating the electrical charge of the bacterial surface. The activity greatly increases methicillin resistance in MRSA strains." +"3.2.2.31","The enzyme serves as a mismatch repair enzyme that works to correct 7,8-dihydro-8-oxoguanine:adenine mispairs that arise in DNA when error-prone synthesis occurs past 7,8-dihydro-8-oxoguanine (GO) lesions in DNA. The enzyme excises the adenine of the mispair, producing an apurinic site sensitive to AP endonuclease activity. After removing the undamaged adenine the enzyme remains bound to the site to prevent EC 3.2.2.23 (MutM) from removing the GO lesion, which could lead to a double strand break. In vitro the enzyme is also active with adenine:guanine, adenine:cytosine, and adenine:7,8-dihydro-8-oxoadenine (AO) mispairs, removing the adenine in all cases." +"3.13.1.7","The enzyme, characterized from the bacterium Thiobacillus thioparus, catalyses a step in the degradation pathway of thiocyanate. This activity is also catalysed by the archaeal EC 3.13.1.5, carbon disulfide lyase." +"5.3.3.21","The enzyme participates in an alternative degradation route of fatty acids with cis-double bonds on odd-number carbons such as oleate and linoleate. The main physiological substrate is (3E,5Z)-tetradeca-3,5-dienoyl-CoA, but other (3E,5Z)-dienoyl-CoAs with varying carbon chain lengths are also substrates." +"6.3.2.52","Two jasmonoyl-L-amino acid synthetases have been described from Nicotiana attenuata [3] and one from Arabidopsis thaliana [1]. The N. attenuata enzymes generate jasmonoyl-L-isoleucine, jasmonoyl-L-leucine, and jasmonoyl-L-valine. The enzyme from A. thaliana could catalyse the addition of many different amino acids to jasmonate in vitro [1,4,5]. While the abundant form of jasmonate in plants is (-)-jasmonate, the active form of jasmonoyl-L-isoleucine is (+)-7-iso-jasmonoyl-L-isoleucine." +"1.7.1.17","Requires FMN. The enzyme catalyses the reductive cleavage of an azo bond in aromatic azo compounds to form the corresponding amines. Does not accept NADPH. cf. EC 1.7.1.6, azobenzene reductase." +"1.13.11.85","The enzyme, studied mainly from the bacterium Xanthomonas sp. 35Y, catalyses the cleavage of the double bonds in natural and synthetic rubber (cis-1,4-polyisoprene polymers), generating ends that contain ketone and aldehyde groups. The enzyme from Xanthomonas sp. 35Y contains two c-type cytochromes. It attacks the substrate from its end, producing a single product of 15 carbons." +"1.14.14.70","A cytochrome P-450 (heme-thiolate) protein isolated from Oryza sativa (rice). Participates in the pathway for the biosynthesis of oryzalexins, a group of related phytoalexins produced by rice. Can also use 9beta-pimara-7,15-diene as substrate (cf. EC 1.14.14.68, syn-pimaradiene 3-monooxygenase)." +"1.14.14.71",Isolated from the plant Siraitia grosvenorii (monk fruit). +"1.14.14.72",A cytochrome P-450 (heme-thiolate) protein isolated from the plant Persicaria hydropiper (water pepper). +"1.14.19.54","A P-450 (heme-thiolate) cytochrome. The enzyme from Papaver rhoeas (field poppy) is specific for (S)-reticuline and does not act on the (R)-form. The enzyme from Papaver somniferum (opium poppy), which is involved in the biosynthesis of morphine and related alkaloids, forms a fusion protein with EC 1.5.1.27, 1,2-dehydroreticulinium reductase (NADPH), which catalyses the reduction of 1,2-dehydroreticuline to (R)-reticuline, thus forming an epimerase system that converts (S)-reticuline to (R)-reticuline." +"1.14.19.55","Contains FAD. The enzyme, described from epiphytic marine bacteria of the genera Pseudoalteromonas and Marinomonas, is an unusual single-component FAD-dependent halogenase that contains a distinct NAD(P)H binding domain and does not require an additional flavin reductase for activity. The enzyme catalyses a bromination of its substrate, followed by a second bromination concurrent with decarboxylation." +"1.14.19.56","The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a flavin-dependent chlorinase that participates in the biosynthesis of the antibacterial and antifungal compound pyoluteorin." +"1.14.19.57","The enzyme, characterized from marine bacteria of the Pseudoalteromonas genus, belongs to a family of FAD-dependent halogenases that act on acyl-carrier protein-tethered substrates. It catalyses three successive rounds of bromination. While the order has not been verified, it is believed to resemble that of EC 1.14.19.56, S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] chlorinase, due to significant sequence homology. Reduced FAD is provided in situ by a dedicated reductase and diffuses into the active site, where it reacts with the oxygen and bromide ion, resulting in formation of a bromoamine intermediate on a catalytic lysine side chain, and the eventual transfer of the bromide to the substrate. The enzyme from Pseudoalteromonas luteoviolacea 2ta16 is specific for bromide and does not accept chloride." +"1.14.19.58","A flavin-dependent halogenase. The enzyme from the bacterium Streptomyces rugosporus catalyses halogenation of the C-5 position of tryptophan during the biosynthesis of the antibiotic compound pyrroindomycin B. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. cf. EC 1.14.19.59, tryptophan 6-halogenase and EC 1.14.19.9, tryptophan 7-halogenase." +"1.14.19.59","The enzyme is a flavin-dependent halogenase that has been described from several bacterial species. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.9, tryptophan 7-halogenase." +"1.14.19.60","An FAD-dependent halogenase. The enzyme, characterized from the bacterium Kutzneria sp. 744, works in tandem with EC 1.14.19.9, tryptophan 7-halogenase, (ktzQ) to generate 6,7-dichloro-L-tryptophan, which is incorporated as a pyrroloindoline in the kutznerides family of natural products. It has a 120-fold preference for 7-chloro-L-tryptophan over L-tryptophan as substrate." +"1.14.20.4","The enzyme requires iron(II) and ascorbate. It is involved in the pathway by which many flowering plants make anthocyanin flower pigments (glycosylated anthocyandins). The enzyme hydroxylates the C-3 carbon, followed by a trans diaxial elimination, forming a C-2,C-3 enol. The product loses a second water molecule to form anthocyanidins. When assayed in vitro, non-enzymic epimerization of the product can lead to formation of dihydroflavanols. Thus when the substrate is leucocyanidin, a mixture of (+)-taxifolin and (+)-epitaxifolin are formed. The enzyme can also oxidize the formed (+)-taxifolin to quercetin (cf. EC 1.14.20.6, flavonol synthase) [2,3]." +"1.14.20.5","The enzyme, which has been found in rice and in members of the Apiaceae (a plant family), is a member of the 2-oxoglutarate-dependent dioxygenases, and requires ascorbate and Fe2+ for full activity." +"1.14.20.6","In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from Citrus unshiu (satsuma mandarin) also has a non-specific activity that trans-hydroxylates the flavanones (2S)-naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively [2]. Requires Fe2+." +"1.14.20.7","This is one of two simultaneous reactions catalysed by the enzyme, which is responsible for ethene (ethylene) production in bacteria of the Pseudomonas syringae group. In the other reaction [EC 1.13.12.19, 2-oxoglutarate dioxygenase (ethene-forming)] the enzyme catalyses the dioxygenation of 2-oxoglutarate forming ethene and three molecules of carbon dioxide.The enzyme catalyses two cycles of the ethene-forming reaction for each cycle of the succinate-forming reaction, so that the stoichiometry of the products ethene and succinate is 2:1. The product of the enzyme, L-glutamate 5-semialdehyde, exists in equilibrium with the cyclic form (S)-1-pyrroline-5-carboxylate." +"1.14.20.8","The enzyme, characterized from the plant Sinopodophyllum hexandrum (mayapple), is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold." +"2.1.1.348","This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH." +"2.4.1.353","The enzyme, isolated from the fungus Sordaria araneosa, is involved in the biosynthesis of the glycoside antibiotic sordarin." +"2.4.1.354","The enzyme, characterized from Prunus dulcis (almond), is involved in the biosynthesis of the cyanogenic glycosides (R)-prunasin and (R)-amygdalin." +"2.4.1.355",Involved in the biosynthesis of poly(ribitol-phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-beta-D-glucosamine to the OH group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.70 [poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase]. +"2.4.2.59","This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme." +"2.4.2.60","This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway. It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo [3]. The homologous enzyme in archaea (EC 2.4.2.59, sulfide-dependent adenosine diphosphate thiazole synthase) uses sulfide as sulfur donor." +"2.5.1.143","This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN)." +"3.2.1.207","This eukaryotic enzyme cleaves off sequentially the two alpha-1,3-linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature N-glycosylated proteins." +"3.5.1.128","The enzyme, present in animals, fungi and bacteria, is involved in clearing cells of the toxic compound deaminated glutathione, which can be produced as an unwanted side product by several transaminases." +"5.3.3.22","The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase." +"5.5.1.31","The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the hapalindole family of alkaloids. The enzyme is a heterodimeric complex." +"5.5.1.32","The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, forms the core structure of the 12-epi-hapalindole family of alkaloids." +"5.5.1.33","The enzyme, characterized from multiple species of the cyanobacterial genus Fischerella, participates in the biosynthesis of the terpenoid indole alkaloids 12-epi-fischerindoles." +"6.2.1.53","The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It catalyses the activation of L-proline to an adenylate form, followed by its transfer to the 4'-phosphopantheine moiety of an L-prolyl-carrier protein." +"6.2.1.54","The enzyme is involved in the modification of wall teichoic acids, as well as type I and IV lipoteichoic acids, with D-alanine residues. It activates D-alanine using ATP to form a high-energy (D-alanyl)adenylate intermediate and subsequently transfers the alanyl moiety to the covalently-bound phosphopantheinyl cofactor of a D-alanyl-carrier protein (DltC)." +"1.2.1.100","The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6)." +"1.3.1.114","Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses two subsequent reductions of the double bonds within the bile acid A/B rings, following 7alpha-dehydration." +"1.3.1.115","Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7beta anomers. cf. EC 1.3.1.116, 7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase." +"1.3.1.116","Contains FAD and FMN. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses the stereo-specific oxidation of its substrate and has no activity with the 7alpha anomer. cf. EC 1.3.1.115, 3-oxocholoyl-CoA 4-desaturase." +"1.3.1.117",Isolated from Malus X domestica (apple). Involved in dihydrochalcone biosynthesis. +"1.3.99.39","The enzyme, found in green sulfur bacteria, some cyanobacteria and some actinobacteria, introduces additional double bonds to the carotenoid beta-end group, leading to aromatization of the ionone ring. As a result, one of the methyl groups at C-1 is transferred to position C-2. It is involved in the biosynthesis of carotenoids with phi-type aromatic end groups such as chlorobactene, beta-isorenieratene, and isorenieratene." +"1.3.99.40","The enzyme, found in purple sulfur bacteria (Chromatiaceae) and some cyanobacteria, is involved in the biosynthesis of carotenoids that contain chi-type end groups, such as okenone, renierapurpurin, and synechoxanthin." +"1.14.13.240","Contains FAD. The enzyme from the bacterium Escherichia coli (UbiI) catalyses the first hydroxylation during the aerobic biosynthesis of ubiquinone. The enzyme from the bacterium Neisseria meningitidis (UbiM) can also catalyse the two additional hydroxylations that occur in the pathway (cf. EC 1.14.99.60, 3-demethoxyubiquinol 3-hydroxylase)." +"1.14.13.241","Contains FAD. The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine (vitamin B6). Although the enzyme was initially thought to be a dioxygenase, oxygen-tracer experiments have suggested that it is a monooxygenase, incorporating only one oxygen atom from molecular oxygen into the product. The second oxygen atom originates from a water molecule, which is regenerated during the reaction and thus does not show up in the reaction equation." +"1.14.13.242","Contains FAD. The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6). Although the enzyme was initially thought to be a dioxygenase, oxygen-tracer experiments have shown that it is a monooxygenase, incorporating only one oxygen atom from molecular oxygen. The second oxygen atom that is incorporated into the product originates from a water molecule, which is regenerated during the reaction and thus does not show up in the reaction equation." +"1.14.14.73","This is one of the activities carried out by some microsomal cytochrome P-450 monooxygenases. A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32, albendazole monooxygenase (flavin-containing)), but it is estimated that cytochrome P-450s are responsible for 70% of the activity." +"1.14.14.74","CYP2J2 is a microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the terminal carbon of the propylsulfanyl chain in albendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. cf. EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming)." +"1.14.14.75","CYP2C19 is microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the benzene ring of fenbendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. This activity is also carried out by CYP2J2. cf. EC 1.14.14.74, albendazole monooxygenase (hydroxylating). CYP2C19 does not act on albendazole." +"1.14.14.76",This cytochrome P-450 (heme thiolate) enzyme has been characterized from the plant Oryza sativa (rice). It may be involved in production of oryzadione. +"1.14.14.77","The enzyme has been characterized from the cyanogenic millipede Chamberlinius hualienensis. Unlike plant enzymes that can catalyse this reaction (EC 1.14.14.44, phenylacetaldehyde oxime monooxygenase), this enzyme cannot act on phenylacetaldehyde oximes. It can accept (4-hydroxyphenyl)acetonitrile, (2-methylphenyl)acetonitrile, and (3-methylphenyl)acetonitrile as substrates at a lower rate." +"1.14.14.78","A cytochrome P-450 (heme-thiolate) protein. Isolated from human tissue. The enzyme will also act on menaquinone-4. Prolonged action of CYP4F2, but not CYP4F11, on the omega hydroxyl group oxidizes it to the corresponding carboxylic acid. CYP4F2 also oxidizes leukotriene B4; see EC 1.14.14.94, leukotriene-B4 20-monooxygenase [1]." +"1.14.14.79",A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid. +"1.14.14.80","A cytochrome P-450 (heme thiolate) enzyme. The plant enzyme CYP704B1, which is involved in the synthesis of sporopollenin, a complex polymer found at the outer layer of spores and pollen, acts on palmitate (18:0), stearate (18:0) and oleate (18:1). The plant enzyme CYP86A1 also acts on laurate (12:0). The enzyme from the yeast Starmerella bombicola (CYP52M1) acts on C16 to C20 saturated and unsaturated fatty acids and can also hydroxylate the (omega-1) position. The mammalian enzyme CYP4A acts on laurate (12:0), myristate (14:0), palmitate (16:0), oleate (18:1), and arachidonate (20:4)." +"1.14.14.81","A cytochrome P-450 (heme-thiolate) protein found in plants. The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin." +"1.14.14.82","A cytochrome P-450 (heme-thiolate) protein found in plants. Acts on a number of flavonoids, including the flavanone naringenin and the flavone apigenin. Does not act on 4-coumarate or 4-coumaroyl-CoA." +"1.14.14.83","A cytochrome P-450 (heme thiolate) protein found in plants. Also hydroxylates nerol and citronellol, cf. EC 1.14.14.84, linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}. The cloned enzyme also catalysed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.14.82, flavonoid 3'-monooxygenase) [3]." +"1.14.14.84",A cytochrome P-450 (heme-thiolate) protein found in plants. The secondary electron donor is a specific [2Fe-2S] ferredoxin from the same bacterial strain. +"1.14.14.85","The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme-thiolate) enzyme. It catalyses a reaction in the pathway leading to biosynthesis of monoterpenoid indole alkaloids." +"1.14.14.86",A cytochrome P-450 (heme thiolate) protein found in plants. Catalyses three successive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid. +"1.14.14.87","A cytochrome P-450 (heme thiolate) protein found in plants. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively." +"1.14.15.27",The bacterial cytochrome P-450 enzyme is involved in the biosynthesis of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex. +"1.14.15.28","This cytochrome P-450 (heme-thiolate) enzyme, found in several bacterial pathogens, is involved in degradation of the host cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol. The products are exclusively in the (25R) conformation. The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.15.29, cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]. The enzyme can receive electrons from ferredoxin reductase in vitro, its natural electron donor is not known yet." +"1.14.15.29","A cytochrome P-450 (heme-thiolate) protein found in several bacterial pathogens. The enzyme is involved in degradation of the host's cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol [4]. The products are exclusively in the (25S) configuration. The enzyme is part of a two-component system that also includes a ferredoxin reductase (most likely KshB, which also interacts with EC 1.14.15.30, 3-ketosteroid 9alpha-monooxygenase). The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.15.28, cholest-4-en-3-one 27-monooxygenase." +"1.14.15.30","The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It forms a two-component system with a ferredoxin reductase (KshB). The enzyme contains a Rieske-type iron-sulfur center and non-heme iron. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione." +"1.14.19.61","The enzyme, characterized from the bacterium Bradyrhizobium elkanii, catalyses the final step in the biosynthesis of the nodulation enhancer compound rhizobitoxine." +"1.14.20.9","The enzyme is a member of the Fe2+, 2-oxoglutarate-dependent oxygenases and requires Fe2+. It has been characterized from bacteria that form the isonitrile-functionalized compound paerucumarin. cf. EC 1.14.20.10, L-tyrosine isonitrile desaturase/decarboxylase." +"1.14.20.10","The enzyme, characterized from the bacterium Xenorhabdus nematophila, is involved in rhabduscin biosynthesis. The enzyme is a member of the Fe2+, 2-oxoglutarate-dependent oxygenases. It is similar to EC 1.14.20.9, L-tyrosine isonitrile desaturase. However, the latter does not catalyse a decarboxylation of the substrate." +"1.14.20.11","The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids. The enzyme catalyses an Fe2+, 2-oxoglutarate-dependent monooxygenation at C-3, which is followed by decarboxylation and dehydration, resulting in the generation of a cis C-C double bond. cf. EC 1.14.20.12, 3-[(E)-2-isocyanoethenyl]-1H-indole synthase." +"1.14.20.12","The enzyme has been characterized from an unidentified soil bacterium. It catalyses an Fe2+, 2-oxoglutarate-dependent monooxygenation at C-3, which is followed by decarboxylation and dehydration, resulting in the generation of a trans C-C double bond. cf. EC 1.14.20.11, 3-[(Z)-2-isocyanoethenyl]-1H-indole synthase." +"1.14.20.13",Requires Fe2+ and ascorbate. +"1.14.99.60","This prokaryotic enzyme catalyses the last hydroxylation reaction during the biosynthesis of ubiquinone. The eukaryotic enzyme is classified under EC 1.14.13.253, 3-demethoxyubiquinone 3-hydroxylase (NADH)." +"1.18.6.2","Requires Mg2+. This enzyme, originally isolated from the bacterium Azotobacter vinelandii, is a complex of two components (namely dinitrogen reductase and dinitrogenase). Dinitrogen reductase is a [4Fe-4S] protein, which, in the presence of ATP, transfers an electron from ferredoxin to the dinitrogenase component. Dinitrogenase is a vanadium-iron protein that reduces dinitrogen to two molecules of ammonia in three successive two-electron reductions via diazine and hydrazine. Compared with molybdenum-dependent nitrogenase (EC 1.18.6.1), this enzyme produces more dihydrogen and consumes more ATP per dinitrogen molecule being reduced. Unlike EC 1.18.6.1, this enzyme can also use CO as substrate, producing ethene, ethane and propane [7,9]." +"2.3.1.269","This bacterial enzyme transfers a fatty acid from a membrane phospholipid to form an amide linkage with the N-terminal cysteine residue of apolipoproteins, generating a triacylated molecule." +"2.3.1.270",This bacterial enzyme catalyses the second step in the formation of ornithine lipids. +"2.3.1.271","The enzyme, characterized from the yeast Saccharomyces cerevisiae Sigma1278b, N-acetylates L-glutamate 5-semialdehyde, an L-proline biosynthesis/utilization intermediate, into N-acetyl-L-glutamate 5-semialdehyde, an intermediate of L-arginine biosynthesis, under oxidative stress conditions. Its activity results in conversion of L-proline to L-arginine, and reduction in the concentration of L-glutamate 5-semialdehyde and its equilibrium partner, (S)-1-pyrroline-5-carboxylate, which has been linked to production of reactive oxygen species stress. The enzyme also acts on (S)-1-acetylazetidine-2-carboxylate, a toxic L-proline analog produced by some plants, resulting in its detoxification and conferring resistance on the yeast." +"2.3.1.272","The enzyme from the bacterium Pseudomonas sp. YGJ3 is composed of three subunits named PhlA, PhlB and PhlC. Production of 2,4-diacetylphloroglucinol, which has antibiotic activity, is strongly inhibited by chloride ions." +"2.4.1.356","The enzyme, characterized from the halophilic archaeon Haloferax volcanii, participates in the protein N-glycosylation pathway. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60) and is alpha,omega-saturated. However, in vitro the enzyme was also able to act on a substrate with an unsaturated end." +"2.4.1.357",Isolated from Malus X domestica (apple). Phlorizin inhibits sodium-linked glucose transporters. It gives the characteristic flavour of apples and cider. +"2.5.1.144","In plants, the activity is catalysed by a chloroplastic enzyme that plays an important role in chloroplast function and is essential for light-dependent redox regulation within the chloroplast. The bacterial enzyme also catalyses the activity of EC 2.5.1.47, cysteine synthase. cf. EC 2.8.5.1, S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)." +"2.5.1.145","This bacterial enzyme, which is associated with the membrane, catalyses the transfer of an sn-1,2-diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine of a prolipoprotein, the first step in the formation of mature triacylated lipoproteins." +"2.5.1.146","The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids." +"2.7.7.100","Contains Zn2+. The enzyme catalyses the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea, by catalysing the ATP-dependent formation of a SAMP adenylate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage. The product of this activity can accept a sulfur atom to form a thiocarboxylate moiety that acts as a sulfur carrier involved in thiolation of tRNA and other metabolites such as molybdopterin. Alternatively, the enzyme can also catalyse the transfer of SAMP from its activated form to an internal cysteine residue, leading to a process termed SAMPylation (see EC 6.2.1.55, E1 SAMP-activating enzyme)." +"2.8.5.1","The enzyme, which has been characterized from the bacterium Mycobacterium tuberculosis, has no activity with O-acetyl-L-serine. Requires pyridoxal 5'-phosphate. cf. EC 2.5.1.144, S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)." +"3.1.6.20","Contains Mn2+. The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. It catalyses two reactions in the pathway. In both cases the enzyme hydrolyses a sulfonate moiety that is bound (either directly or via a sulfane) to a cysteine residue of a SoxY protein, releasing sulfate. The enzyme from Paracoccus pantotrophus contains a pyroglutamate (cycloglutamate) at its N-terminus." +"3.13.1.8","The enzyme, found in bacteria and archaea, is involved in removing the (R) isomer of S-adenosyl-L-methionine from the cell. It catalyses a nucleophilic attack of water at the C5' carbon of S-adenosyl-L-methionine to generate adenosine and L-methionine." +"4.1.1.110","The enzyme participates in an alternative mevalonate pathway that takes place in extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.99, phosphomevalonate decarboxylase." +"4.1.1.111",The enzyme from archaea is involved in an alternative heme biosynthesis pathway. The enzyme from denitrifying bacteria is involved in the heme d1 biosynthesis pathway. +"4.4.1.37","This enzyme, found in Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. The process starts when one enzyme molecule adenylates pyridinium-3,5-dicarboxylate mononucleotide (P2CMN) and covalently binds the adenylated product to an intrinsic cysteine residue. Next, the enzyme cleaves the carbon-sulfur bond, liberating pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide (PCTMN) and leaving a 2-aminoprop-2-enoate (dehydroalanine) residue attached to the protein. Since the cysteine residue is not regenerated in vivo, the enzyme is inactivated during the process. A second enzyme molecule then repeats the process with PCTMN, adenylating it and covalently binding it to the same cysteine residue, followed by liberation of pyridinium-3,5-bisthiocarboxylate mononucleotide (P2TMN) and the inactivation of the second enzyme molecule. cf. EC 4.4.1.45, extrinsic cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase." +"6.2.1.55","Contains Zn2+. The enzyme catalyses the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea. SAMPs are involved in protein degradation, and also act as sulfur carriers involved in thiolation of tRNA and other metabolites such as molybdopterin. The enzyme catalyses the ATP-dependent formation of a SAMP adenylate intermediate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage (reaction 1). This intermediate can accept a sulfur atom to form a thiocarboxylate moiety in a mechanism that is not yet understood. Alternatively, the E1 enzyme can transfer SAMP from its activated form to an internal cysteine residue, releasing AMP (reaction 2). In this case SAMP is subsequently transferred to a lysine residue in a target protein in a process termed SAMPylation. Auto-SAMPylation (attachment of SAMP to lysine residues within the E1 enzyme) has been observed. cf. EC 2.7.7.100, SAMP-activating enzyme." +"1.14.14.88",A cytochrome P-450 (heme-thiolate) protein. Also acts on biochanin A and other isoflavones with a 4'-methoxy group. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. +"1.14.14.89","A cytochrome P-450 (heme-thiolate) protein. Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.14.90, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones." +"1.14.14.90","A cytochrome P-450 (heme-thiolate) protein. Acts on daidzein, formononetin and genistein. EC 1.14.14.89, 4'-methoxyisoflavone 2'-hydroxylase, has the same reaction but is more specific as it requires a 4'-methoxyisoflavone." +"1.14.14.91",A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis. +"1.14.14.92",A cytochrome P-450 (heme-thiolate) protein found in Aspergillus fungi. +"1.14.14.93",A cytochrome P-450 (heme-thiolate) protein found in soybean. The product of the reaction is the biosynthetic precursor of the glyceollin phytoalexins. +"1.14.14.94",A cytochrome P-450 (heme-thiolate) protein found in mammals. +"1.14.14.95",A cytochrome P-450 (heme-thiolate) protein. This plant enzyme catalyses three steps in a pathway that leads to the biosynthesis of many sesquiterpenoid lactones. +"1.14.14.96","A cytochrome P-450 (heme-thiolate) protein, found in plants. It also acts on trans-5-O-(4-coumaroyl)shikimate." +"1.14.14.97","A cytochrome P-450 (heme-thiolate) protein involved in the biosynthesis of isoquinoline alkaloids in plants. It also hydroxylates (S)-cis-N-methyltetrahydrothalifendine, and (S)-cis-N-methyltetrahydropalmatine." +"1.14.14.98",A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants. +"1.14.14.99",A cytochrome P-450 (heme-thiolate) protein from peppermint (Mentha piperita). +"1.14.14.100",A cytochrome P-450 (heme-thiolate) protein involved in benzophenanthridine alkaloid synthesis in higher plants. +"1.14.14.101",A cytochrome P-450 (heme-thiolate) protein from the plant Thalictrum bulgaricum. +"1.14.14.102",A cytochrome P-450 (heme-thiolate) protein involved in benzylisoquinoline alkaloid synthesis in higher plants. +"1.14.14.103",A cytochrome P-450 (heme-thiolate) protein from the plant Madagascar periwinkle (Catharanthus roseus). +"1.14.14.104",A cytochrome P-450 (heme-thiolate) protein from the plant Rauvolfia serpentina. Forms a stage in the biosynthesis of the indole alkaloid ajmaline. +"1.14.14.105",This microsomal cytochrome-P-450 (heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel). +"1.14.14.106",This cytochrome-P-450(heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel). +"1.14.14.107","A cytochrome P-450 (heme-thiolate) protein from plants. Catalyses three sucessive oxidations of ent-kaurenoic acid. The second step includes a ring-B contraction giving the gibbane skeleton. In pumpkin (Cucurbita maxima) ent-6alpha,7alpha-dihydroxykaur-16-en-19-oate is also formed." +"1.14.14.108","A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid. Involved in the degradation of (+)-camphor. Requires a dedicated NADH-FMN reductase [cf. EC 1.5.1.42, FMN reductase (NADH)] [1-3]. Can accept several bicyclic ketones including (+)- and (-)-camphor [6] and adamantanone [4]. The product spontaneously converts to [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate." +"1.14.14.109","A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses)." +"1.14.14.110","A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses)." +"1.14.14.111",A cytochrome P-450 (heme-thiolate) protein. The enzyme from rice (Oryza sativa) is involved in the biosynthesis of the phytoalexin momilactone. It also acts similarly on 9beta-stemod-13(17)-ene. +"1.14.14.112",A cytochrome P-450 (heme-thiolate) protein. The enzyme from rice (Oryza sativa) is involved in the biosynthesis of the antifungal phytocassanes. +"1.14.14.113",A cytochrome P-450 (heme-thiolate) protein. The recommended numbering of humulene gives 10-hydroxy-alpha-humulene as the product rather than 8-hydroxy-alpha-humulene as used by the reference. See {iupac/sectionF/index::Section F: Natural Product Nomenclature}. +"1.14.14.114",A cytochrome P-450 (heme-thiolate) protein. Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin. +"1.14.14.115",A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plant Glycyrrhiza uralensis (licorice) is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin. The enzyme from the plant Medicago truncatula can also hydroxylate beta-amyrin. +"1.14.14.116",A cytochrome P-450 (heme-thiolate) protein isolated from the saprophytic mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis. Does not react with (1'R)-averantin. +"1.14.14.117",A cytochrome P-450 (heme-thiolate) protein. Isolated from the mold Aspergillus parasiticus. +"1.14.14.118","A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen." +"1.14.14.119",A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the indole alkaloid verruculogen. +"1.14.14.120",A cytochrome P-450 (heme-thiolate) protein isolated from ginseng (Panax ginseng). Involved in the biosynthetic pathway of ginsenosides. +"1.14.14.121",A cytochrome P-450 (heme-thiolate) protein isolated from the rhizomes of ginseng (Panax ginseng). Involved in the biosynthetic pathway of ginsenosides. +"1.14.14.122",A cytochrome P-450 (heme-thiolate) protein. Isolated from Oryza sativa (rice). Oryzalexin E is a phytoalexin. +"1.14.14.123",A cytochrome P-450 (heme-thiolate) protein. Isolated from Oryza sativa (rice). Oryzalexin D is a phytoalexin. +"1.14.14.124","A cytochrome P-450 (heme-thiolate) protein. The dehydration of 3alpha-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous [1,2]. The enzyme from fungi also catalyses the reaction of EC 1.14.14.125, monacolin L hydroxylase [3]." +"1.14.14.125","A cytochrome P-450 (heme-thiolate) protein. The enzyme from fungi also catalyses the reaction of EC 1.14.14.124, dihydromonacolin L hydroxylase." +"1.14.14.126","A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago truncatula (barrel medic) (CYP716A12) can also convert alpha-amyrin and lupeol to ursolic acid and betulinic acid, respectively. The enzyme from Maesa lanceolata (false assegai) (CYP16A75) does not catalyse the reaction to completion, resulting in accumulation of both intermediates." +"1.14.14.127","A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in insects except for Lepidoptera (moths and butterflies) is specific for methyl farnesoate (cf. EC 1.14.14.128, farnesoate epoxidase) [1,2]. " +"1.14.14.128","A cytochrome P-450 (heme-thiolate) protein. The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.14.127, methyl farnesoate epoxidase) [1,2]. It is involved in the synthesis of juvenile hormone." +"1.14.14.129","A cytochrome P-450 (heme-thiolate) protein. The enzymes from solanaceous plants are involved in the biosynthesis of stigmatic estolide, a lipid-based polyester that forms a major component of the exudate." +"1.14.14.130","A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in the synthesis of sporopollenin - a complex polymer found at the outer layer of spores and pollen. It can also act on decanoate (C10), myristate (C14), and palmitate (C16) with lower activity. The enzyme also produces a small amount of products that are hydroxylated at neighboring positions (C-6, C-8 and C-9)." +"1.14.14.131","A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs." +"1.14.14.132","A cytochrome P-450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency." +"1.14.14.133","A cytochrome P-450 (heme-thiolate) protein that uses a flavodoxin-like redox partner to reduce the heme iron. Isolated from the bacterium Citrobacter braakii, which can use 1,8-cineole as the sole source of carbon." +"1.14.14.134",A cytochrome P-450 (heme-thiolate) protein. Found in plants and participates in the biosynthesis of soybean saponins. +"1.14.14.135",A cytochrome P-450 (heme-thiolate) protein purified from soybean. +"1.14.14.136",A cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina. +"1.14.14.137","A cytochrome P-450 (heme-thiolate) protein found in plants. Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone [1]. CO inhibits the reaction, but its effects can be reversed by the presence of blue light [1]. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously." +"1.14.14.138",A cytochrome P-450 (heme-thiolate) protein from Mesocricetus auratus (golden hamster). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters [1]. +"1.14.14.139","A cytochrome P-450 (heme-thiolate) protein found in mammals. This is the key enzyme in the biosynthesis of the bile acid cholate. The enzyme can also hydroxylate 5beta-cholestane-3alpha,7alpha-diol at the 25 and 26 position, but to a lesser extent [2]." +"1.14.14.140","A cytochrome P-450 (heme-thiolate) protein isolated from licorice plants (Glycyrrhiza echinata L.). The immediate product is likely 2-hydroxyliquiritigenin, which spontaneously rearranges to form licodione." +"1.14.14.141","This microsomal cytochrome P-450 (heme-thiolate) enzyme is rather specific for (+)-marmesin, although it can also accept 5-hydroxymarmesin to a much lesser extent. Furanocoumarins protect plants from fungal invasion and herbivore attack. (+)-Columbianetin, the angular furanocoumarin analogue of the linear furanocoumarin (+)-marmesin, acts as a competitive inhibitor even though it is not a substrate." +"1.14.14.142","A membrane-bound cytochrome P-450 (heme-thiolate) protein that is associated with the endoplasmic reticulum [1,2]. This enzyme is specific for sophoraflavanone B as substrate. Along with EC 2.5.1.70 (naringenin 8-dimethylallyltransferase) and EC 2.5.1.71 (leachianone G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone G biosynthetic pathway." +"1.14.14.143","A cytochrome P-450 (heme-thiolate) protein. The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan [1]. This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalysed by EC 1.14.14.99, (S)-limonene 3-monooxygenase [1]." +"1.14.14.144",A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). Activity is induced by wounding of the plant tissue [2]. +"1.14.14.145","A cytochrome P-450 (heme-thiolate) protein. This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine) [1], and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine) [3]. The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene." +"1.14.14.146",A cytochrome P-450 (heme-thiolate) protein isolated from the plant Croton sublyratus. +"1.14.14.147","A cytochrome P-450 (heme-thiolate) protein involved in brassinosteroid biosynthesis in plants. The enzyme has a relaxed substrate specificity, and C-23 hydroxylation can occur at different stages in the pathway. In Arabidopsis thaliana two isozymes, encoded by the CYP90C1 and CYP90D1 genes, have redundant activities." +"1.14.14.148",This cytochrome P-450 (heme-thiolate) enzyme from wild parsnip is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'. +"1.14.14.149",A cytochrome P-450 (heme-thiolate) protein. Kinetic studies suggest that 1beta-hydroxyepiaristolochene is mainly formed first followed by hydroxylation at C-3. However the reverse order via 3alpha-hydroxyepiaristolochene does occur. +"1.14.14.150","A cytochrome P-450 (heme-thiolate) protein from chicory plants. The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien-12-oate to give 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which spontaneously cyclises to form the lactone ring." +"1.14.14.151","A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plant Hyoscymus muticus also hydroxylates valencene at C-2 to give the alpha-hydroxy compound, nootkatol, and this is converted into nootkatone. 5-Epiaristolochene and epieremophilene are hydroxylated at C-2 to give a 2beta-hydroxy derivatives that are not oxidized further." +"1.14.14.152","A cytochrome P-450 (heme-thiolate) protein from the plant Glycyrrhiza uralensis (Chinese licorice) that participates in the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-beta-amyrin to 11alpha,30-dihydroxy-beta-amyrin but this is not thought to be part of glycyrrhizin biosynthesis." +"1.14.14.153","A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses)." +"1.14.14.154","This cytochrome P-450 (heme-thiolate) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond." +"1.14.15.31",A cytochrome P-450 (heme-thiolate) protein involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus. +"1.14.15.32",A cytochrome P-450 (heme-thiolate) protein found in the bacterium Streptomyces avermitilis. The enzyme is involved in the biosynthesis of pentalenolactone and related antibiotics. +"1.14.15.33",A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin. +"1.14.15.34","A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria." +"1.14.15.35",A cytochrome P-450 (heme-thiolate) protein isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin. +"1.14.19.62",A cytochrome P-450 (heme-thiolate) protein. Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids. +"1.14.19.63","A cytochrome P-450 (heme-thiolate) enzyme catalysing an oxidative reaction that does not incorporate oxygen into the product. Catalyses a step in the biosynthesis of (-)-maackiain, the main pterocarpan phytoalexin in chickpea (Cicer arietinum)." +"1.14.19.64",A cytochrome P-450 (heme-thiolate) protein catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the second methylenedioxy bridge of the protoberberine alkaloid stylopine from oxidative ring closure of adjacent phenolic and methoxy groups of cheilanthifoline. +"1.14.19.65","A cytochrome P-450 (heme-thiolate) protein catalysing an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid cheilanthifoline by the oxidative ring closure of adjacent phenolic and methoxy groups of scoulerine. cf. EC 1.14.19.73, (S)-nandinine synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-nandinine." +"1.14.19.66",A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine. +"1.14.19.67",A cytochrome P-450 (heme-thiolate) protein found in plants. Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product. +"1.14.19.68",A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme catalyses an oxidative reaction that does not incorporate oxygen into the product. Oxidation of the methoxyphenol group of the alkaloid tetrahydrocolumbamine results in the formation of the methylenedioxy bridge of canadine. +"1.14.19.69","This cytochrome-P-450 (heme-thiolate) enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction, which results in the polymerization of flaviolin to form biflaviolin or triflaviolin without the incorporation of oxygen into the product [1,3]. The products are highly conjugated pigments that protect the bacterium from the deleterious effects of UV irradiation [1]." +"1.14.19.70",A cytochrome P-450 (heme-thiolate) protein from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product. +"1.14.19.71",A cytochrome P-450 (heme-thiolate) protein. The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen. +"1.14.19.72","A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plants Sinopodophyllum hexandrum and Podophyllum peltatum catalyses the formation of a methylenedioxy-bridge. It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs." +"1.14.19.73","A cytochrome P-450 (heme-thiolate) enzyme found in plants. The enzyme catalyses an oxidative reaction that does not incorporate oxygen into the product. Forms the methylenedioxy bridge of the protoberberine alkaloid (S)-nandinine by the oxidative ring closure of adjacent phenolic and methoxy groups of (S)-scoulerine. cf. EC 1.14.19.65, (S)-cheilanthifoline synthase, which catalyses a similar reaction at the other side of the (S)-scoulerine molecule, forming (S)-cheilanthifoline." +"1.17.9.1","This bacterial enzyme contains a flavin (FAD) subunit and a cytochrome c subunit. The flavin subunit abstracts two hydrogen atoms from the substrate, forming a quinone methide intermediate, then hydrates the latter at the benzylic carbon with a hydroxyl group derived from water. The protons are lost to the bulk solvent, while the electrons are passed to the heme on the cytochrome subunit, and from there to azurin, a small copper-binding protein that is co-localized with the enzyme in the periplasm. The first hydroxylation forms 4-hydroxybenzyl alcohol; a second hydroxylation converts this into 4-hydroxybenzaldehyde." +"1.1.1.414","The enzyme, reported from the human gut bacteria Escherichia coli and Bacteroides vulgatus, participates in an L-galactonate degradation pathway." +"1.13.11.86","Requires iron(II). The enzyme, characterized from different bacteria, is a nonheme iron dioxygenase in the bicupin family." +"1.14.14.155","A Baeyer-Villiger monooxygenase isolated from camphor-grown strains of Pseudomonas putida and encoded on the cam plasmid. Involved in the degradation of (-)-camphor. Requires a dedicated NADH---FMN reductase [cf. EC 1.5.1.42, FMN reductase (NADH)] [1,2]. The product spontaneously converts to [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate." +"1.14.14.156","A cytochrome P-450 (heme-thiolate) protein from the plant Arabidopsis thaliana. This enzyme catalyses two successive N-hydroxylations of L-tryptophan, the first steps in the biosynthesis of both auxin and the indole alkaloid phytoalexin camalexin. The product of the two hydroxylations, N,N-dihydroxy-L-tryptophan, is extremely labile and dehydrates spontaneously. The dehydrated product is then subject to a decarboxylation that produces an oxime. It is still not known whether the decarboxylation is spontaneous or catalysed by the enzyme." +"1.14.14.157","A cytochrome P-450 (heme-thiolate) protein. The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses)." +"1.14.14.158",A cytochrome P-450 (heme-thiolate) protein. +"1.14.19.74",A cytochrome P-450 (heme-thiolate) protein. Isolated from Sesamum indicum (sesame) and S. radiatum (black sesame). +"1.14.20.14","The enzyme, characterized from hapalindole-type alkaloids-producing cyanobacteria, is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyses the chlorination of its substrates in a reaction that requires oxygen, chloride ions, iron(II) and 2-oxoglutarate." +"1.14.20.15","The enzyme, characterized from the bacterium Pseudomonas syringae, participates in syringomycin E biosynthesis. The enzyme is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyses the chlorination of its substrate in a reaction that requires oxygen, chloride ions, ferrous iron and 2-oxoglutarate." +"1.14.99.61",Isolated from the bacterium Streptomyces melanosporofaciens M1614-43f2. Involved in the biosynthesis of cyclooctatin. +"1.14.99.62",Isolated from the bacterium Streptomyces melanosporofaciens M1614-43f2. +"1.14.99.63","The enzyme, studied from algae, plants, fungi, and bacteria, adds an oxo group at position 4 of a carotenoid beta ring. It is involved in the biosynthesis of carotenoids such as astaxanthin and flexixanthin. The enzyme does not act on beta rings that are hydroxylated at position 3, such as in zeaxanthin (cf. EC 1.14.99.64, zeaxanthin 4-ketolase). The enzyme from the yeast Xanthophyllomyces dendrorhous is bifuntional and also catalyses the activity of EC 1.14.15.24, beta-carotene 3-hydroxylase." +"1.14.99.64","The enzyme has a similar activity to that of EC 1.14.99.63, beta-carotene 4-ketolase, but unlike that enzyme is able to also act on zeaxanthin." +"1.21.98.4","This bacterial enzyme, which is a member of the radical SAM protein family, catalyses the formation of a C-C bond between C-4 of glutamate and C-3 of tyrosine residues of the PqqA protein (which are separated by three amino acid residues). This is the first enzymic step in the biosynthesis of the bacterial enzyme cofactor pyrroloquinoline quinone (PQQ). The reaction is dependent on the presence of a reductant (flavodoxin) and the accessory protein PqqD." +"2.1.1.349",The enzyme is a dual-specificity methyltransferase that catalyses the last two steps of toxoflavin biosynthesis. Toxoflavin is a major virulence factor of several bacterial crop pathogens. +"2.3.1.273","The enzyme, characterized from mycobacteria, is involved in the biosynthesis of methylglucose lipopolysaccharide (MGLP). The enzyme can also act on 2-O-(alpha-D-glucopyranosyl)-D-glycerate, but with lower activity." +"2.4.1.358",Isolated from strawberries (Fragaria X ananassa). Acts best on phloroisovalerophenone and phlorobutyrophenone but will also glycosylate many other phenolic compounds. A minor product of the reaction is the 5-O-beta-D-glucoside. +"2.5.1.147","The enzyme is involved in the production of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), the precursor of the redox cofactor coenzyme F420, which is found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 4.3.1.32, 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to initiate the reaction." +"2.8.5.2","The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. It catalyses two reactions in the pathway - early in the pathway it attaches a thiosulfate molecule to the sulfur atom of an L-cysteine of a SoxY protein; later it transfers a second thiosulfate molecule to a sulfane group that is already attached to the same cysteine residue." +"4.1.1.112","Requires a divalent metal cation. The enzymes from the fish Gadus morhua (Atlantic cod) and the bacterium Micrococcus luteus prefer Mn2+, while those from the bacteria Pseudomonas putida and Pseudomonas aeruginosa prefer Mg2+. Unlike EC 7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)], there is no evidence of the enzyme's involvement in Na+ transport." +"4.1.99.24","The enzymes from the bacteria Pseudomonas aeruginosa and Xenorhabdus nematophila are involved in the biosynthesis of paerucumarin and rhabduscin, respectively. According to the proposed mechanism, the enzyme forms an imine intermediate composed of linked L-tyrosine and D-ribulose 5-phosphate, followed by loss of the phosphate group and formation of a beta-keto imine and keto-enol tautomerization. This is followed by a C-C bond cleavage, the release of hydroxyacetone, and a retro aldol type reaction that releases formaldehyde and forms the final product [3]. cf. EC 4.1.99.25, L-tryptophan isonitrile synthase." +"4.1.99.25","The enzymes from cyanobacteria that belong to the Nostocales order participate in the biosynthesis of hapalindole-type alkaloids. According to the proposed mechanism, the enzyme forms an imine intermediate composed of linked L-tryptophan and D-ribulose 5-phosphate, followed by loss of the phosphate group and formation of a beta-keto imine and keto-enol tautomerization. This is followed by a C-C bond cleavage, the release of hydroxyacetone, and a retro aldol type reaction that releases formaldehyde and forms the final product [3]. cf. EC 4.1.99.24, L-tyrosine isonitrile synthase." +"4.3.1.32","The enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of factor 420 (coenzyme F420), a metabolite found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC 2.5.1.147, 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to catalyse the condensation reaction." +"4.3.2.10","The enzyme is involved in histidine biosynthesis, as well as purine nucleotide biosynthesis. The enzymes from archaea and bacteria are heterodimeric. A glutaminase component (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is transferred by a 25 A tunnel to a cyclase component, which adds it to the imidazole ring, leading to lysis of the molecule and cyclization of one of the products. The glutminase subunit is only active within the dimeric complex. In fungi and plants the two subunits are combined into a single polypeptide." +"7.1.1.1",The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. +"7.1.1.2","The enzyme is a very large complex that participates in electron transfer chains of mitochondria and aerobic bacteria, transferring two electrons from NADH to a ubiquinone in the membrane's ubiquinone pool while pumping additional protons across the membrane, generating proton motive force. Different reports disagree whether the enzyme pumps 3 or 4 protons. Reversed electron transport through this enzyme can reduce NAD+ to NADH. " +"7.1.2.1","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane." +"7.1.2.2","A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 alpha- and 3 beta-subunits) is connected via the delta-subunit to the membrane sector by several smaller subunits. Within this complex, the gamma- and epsilon-subunits, as well as the 9--12 c subunits rotate by consecutive 120_degree_ angles and perform parts of ATP synthesis. This movement is driven by the H+ electrochemical potential gradient. The V-type (in vacuoles and clathrin-coated vesicles) and A-type (archaeal) enzymes have a similar structure but, under physiological conditions, they pump H+ rather than synthesize ATP." +"7.1.3.1","This enzyme, found in plants and fungi, couples the energy from diphosphate hydrolysis to active proton translocation across the tonoplast into the vacuole. The enzyme acts cooperatively with cytosolic soluble diphosphatases to regulate the cytosolic diphosphate level." +"7.2.1.1","An iron-sulfur flavoprotein, containing two covalently bound molecules of FMN, one noncovalently bound FAD, one riboflavin, and one [2Fe-2S] cluster." +"7.2.1.2","This iron-sulfur and flavin-containing electron transport complex, isolated from the bacterium Acetobacterium woodii, couples the energy from reduction of NAD+ by ferredoxin to pumping sodium ions out of the cell, generating a gradient across the cytoplasmic membrane. " +"7.2.2.1","A multisubunit ATPase transporter found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis. The enzyme is similar to EC 7.1.2.2 (H+-transporting two-sector ATPase) but pumps Na+ rather than H+. By analogy to EC 7.1.2.2, it is likely that the enzyme pumps 4 sodium ions for every ATP molecule that is hydrolysed. cf. EC 7.2.2.3, P-type Na+ transporter and EC 7.2.2.4, ABC-type Na+ transporter." +"7.2.2.2","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports some heavy metals, especially Cd2+, from the cytosol into the vacuole." +"7.2.2.3","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed. Some forms can also export Li+ ions. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.4, ABC-type Na+ transporter." +"7.2.2.4","ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This bacterial enzyme, characterized from Bacillus subtilis, exports Na+ ions out of the cell. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.3, P-type Na+ transporter." +"7.2.4.1","The integral membrane protein MadB from the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 7.2.4.4, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC 7.2.4.2 [oxaloacetate decarboxylase (Na+ extruding)] and EC 7.2.4.3 [(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)] [2]. " +"7.2.4.2",The enzyme from the bacterium Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+. Differs from EC 4.1.1.112 (oxaloacetate decarboxylase) for which there is no evidence for involvement in Na+ transport. +"7.2.4.3","This bacterial enzyme couples the decarboxylation of (S)-methylmalonyl-CoA to propanoyl-CoA to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis. It is a membrane-associated biotin protein and is strictly dependent on sodium ions for activity." +"7.3.2.1","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of phosphate anions. Unlike P-type ATPases, it does not undergo phosphorylation during the transport process." +"7.3.2.2","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of phosphonate and organophosphate anions." +"7.4.2.1","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of polar amino acids. This entry comprises bacterial enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine, octopine and nopaline." +"7.4.2.2","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein. This entry comprises enzymes that import Leu, Ile and Val." +"7.5.2.1","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of maltose and maltose oligosaccharides." +"7.5.2.2","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of lactose, melibiose and raffinose." +"7.6.2.1","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. Different forms of the enzyme move phospholipids such as phosphatidylcholine, lyso-phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, phosphatidyglycerol, sphingomyelin and glucosylceramide from one membrane face to the other ('flippase')." +"7.6.2.2","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them also transport glutathione---drug conjugates (see EC 7.6.2.3, ABC-type glutathione-S-conjugate transporter) while others also show some 'flippase' activity (cf. EC 7.6.2.1, P-type phospholipid transporter)." +"7.6.2.3","A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates. The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole. Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form." +"1.1.1.415","The enzyme, characterized from the plant Papaver somniferum (opium poppy), catalyses the last step in the biosynthesis of the isoquinoline alkaloid noscapine." +"1.2.1.101","The enzyme, characterized from the ascomycete fungus Aspergillus flavus, is specific for L-tyrosine. It contains three domains - an adenylation domain, a peptidyl-carrier protein (PCP) domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the PCP domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to the aldehyde." +"1.3.1.118","InhA is a component of the fatty acid synthase (FAS) II system of Mycobacterium tuberculosis, catalysing an enoyl-[acyl-carrier-protein] reductase step. The enzyme acts on very long and unsaturated fatty acids that form the meromycolic component of mycolic acids. It extends FASI-derived C20 fatty acids to form C60 to C90 mycolic acids. The enzyme, which forms a homotetramer, is the target of the preferred antitubercular drug isoniazid." +"1.3.1.119","This bacterial enzyme can transform various dihydrodiols of chlorobenzenes into the respective catechols, including the dihydrodiols of mono-, di-, tri-, and tetra-chlorinated benzenes. It also accepts the dihydrodiols of various chlorotoluenes. Substrates for the enzyme are generated by the broad spectrum EC 1.14.12.26, chlorobenzene dioxygenase." +"1.5.1.52","The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt." +"1.13.11.87","The enzyme catalyses the cleavage of the double bonds in natural and synthetic rubber, producing a mixture of C20, C25, C30, and higher oligo-isoprenoids with ketone and aldehyde groups at their ends. Two unrelated bacterial enzymes are known to possess this activity - the enzyme from Streptomyces sp. K30 (Lcp) contains a b-type cytochrome, while the enzyme from Xanthomonas sp. 35Y, (RoxB) contains two c-type cytochromes. Both enzymes attack the substrate at random locations, and are not able to cleave the C35 or smaller products into shorter fragments." +"1.14.11.60",Requires iron(II) and ascorbate. A protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants. +"1.14.12.26","This bacterial enzyme is a class IIB dioxygenase, comprising three components - a heterodimeric terminal dioxygenase, a ferredoxin protein, and a ferredoxin reductase. The enzyme acts on a range of aromatic compounds, including mono-, di-, tri-, and tetra-chlorinated benzenes and toluenes." +"1.14.14.159","A cytochrome P-450 (heme thiolate) enzyme characterized from maize. The enzyme catalyses the epoxidation of dolabradiene at C-16, followed by hydroxylation at C-3." +"1.14.14.160","A cytochrome P-450 (heme thiolate) enzyme characterized from maize. The enzyme sequentially oxidizes(S)-beta-macrocarpene via alcohol and aldehyde intermediates to form zealexin A1, a maize phytoalexin that provides biochemical protection against fungal infection." +"1.14.14.161","The enzyme, characterized from the plant Catharanthus roseus, is a cytochrome P-450 (heme thiolate) protein. It catalyses three successive reactions in the pathway leading to biosynthesis of monoterpenoid indole alkaloids." +"1.14.14.162","A cytochrome P-450 (heme thiolate) plant enzyme that catalyses the 2-hydroxylation of multiple flavanones such as (2S)-naringenin, (2S)-eriodictyol, (2S)-pinocembrin, and (2S)-liquiritigenin. The products are meta-stable and exist in an equilibrium with open forms such as 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione." +"1.14.14.163","The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine." +"1.14.14.164",A cytochrome P-450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants. +"1.14.14.165",A cytochrome P-450 (heme-thiolate) protein characterized from the plant Arabidopsis thaliana. Involved in biosynthesis of small cyanogenic compounds that take part in pathogen defense. The enzyme also catalyses the 5-hydroxylation of xanthotoxin [1]. +"1.14.19.75","The enzyme, characterized from the plant Arabidopsis thaliana, acts on both 24:0 and 26:0 fatty acids, introducing a cis double bond at a position 9 carbons from the methyl end. These very-long-chain fatty acids are found as a minor component of seed lipids, but also in the membrane phosphatidylethanolamine and phosphatidylserine, in sphingolipids, as precursors and components of cuticular and epicuticular waxes, and in suberin." +"2.1.1.350","The enzyme, found in a wide range of bacteria and archaea, is a radical SAM (AdoMet) enzyme that utilizes two molecules of S-adenosyl-L-methionine, one as the methyl group donor, and one for the creation of a 5'-deoxyadenosine radical that drives the reaction forward." +"2.3.1.274","The enzyme, found in bacteria, catalyses the synthesis of fatty acyl-phosphate from acyl-[acyl-carrier protein], a step in the most widely distributed bacterial pathway for the initiation of phospholipid formation. While the activity is modestly enhanced by Mg2+, the enzyme does not require a divalent cation." +"2.3.1.275","The enzyme, found in bacteria, catalyses a step in the most widely distributed bacterial pathway for the initiation of phospholipid formation. The enzyme is membrane-bound." +"2.3.1.276","The enzyme, characterized from the archaeon Sulfolobus tokodaii, is also active toward alpha-D-glucosamine 1-phosphate (cf. EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase). In addition, that enzyme contains a second domain that catalyses the activities of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase, EC 2.7.7.24, glucose-1-phosphate thymidylyltransferase, and EC 2.7.7.83, UDP-N-acetylgalactosamine diphosphorylase." +"2.4.1.359","The enzyme, characterized from the halotolerant bacterium Marinobacter adhaerens, is likely responsible for degradation of the compatible solute 2-O-alpha-D-glucopyranosyl-glycerol when the environmental salt concentration decreases. cf. EC 2.4.1.332, 1,2-alpha-glucosylglycerol phosphorylase." +"2.4.2.61",This eukaryotic enzyme catalyses a step in the biosynthesis of the glycan moiety of the membrane protein alpha-dystroglycan. It is specific for the second ribitol 5-phosphate in the nascent glycan chain as acceptor. +"2.7.1.224","The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides." +"2.7.7.101","The enzyme catalyses the synthesis of short RNA sequences that are used as primers for EC 2.7.7.7, DNA-directed DNA polymerase. It is found in bacteria and archaea. The latter also have a second primase system (EC 2.7.7.102, DNA primase AEP)." +"2.7.7.102","The enzyme, which is found in eukaryota and archaea, catalyses the synthesis of short RNA or DNA sequences which are used as primers for EC 2.7.7.7, DNA-directed DNA polymerase." +"2.7.7.103","The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides." +"3.1.1.104","The enzyme, characterized from Mycoplasma spp., contains a binuclear metal center with two zinc cations. The enzyme is specific for the phosphorylated forms, and is unable to hydrolyse non-phosphorylated 1,4-lactones." +"3.2.1.208","The enzyme has been isolated from nontuberculous mycobacteria (e.g. Mycobacterium hassiacum), which accumulate 2-O-(alpha-D-glucopyranosyl)-D-glycerate during growth under nitrogen deprivation." +"3.5.1.129","The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides." +"4.1.1.113","The enzyme, characterized from the smut fungus Ustilago maydis, is involved in an alternative pathway for the biosynthesis of itaconate. cf. EC 4.1.1.6, cis-aconitate decarboxylase." +"5.1.3.42","The enzyme, characterized from the archaeon Sulfolobus tokodaii, participates in a pathway for the biosynthesis of UDP-N-acetyl-alpha-D-galactosamine." +"5.4.2.13","The enzyme, characterized from the archaeon Sulfolobus tokodaii, is also active toward D-glucosamine 6-phosphate (cf. EC 5.4.2.10, phosphoglucosamine mutase)." +"7.1.1.3","Contains a dinuclear centre comprising heme and copper. This terminal oxidase enzyme generates proton motive force by two mechanisms: (1) transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water, and (2) active pumping of protons across the membrane. The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) of enzymes that have been characterized so far is 2. cf. EC 7.1.1.7, ubiquinol oxidase ubiquinol oxidase (electrogenic, proton-motive force generating)." +"7.1.1.4","A copper-containing cytochrome. The enzyme from thermophilic archaea is part of the terminal oxidase and catalyses the reduction of O2 to water, accompanied by the extrusion of protons across the cytoplasmic membrane. " +"7.1.1.5","Cytochrome aa3-600, one of the principal respiratory oxidases from Bacillus subtilis, is a member of the heme-copper superfamily of oxygen reductases, and is a close homologue of the cytochrome bo3 ubiquinol oxidase from Escherichia coli, but uses menaquinol instead of ubiquinol as a substrate.The enzyme also pumps protons across the membrane bilayer, generating a proton motive force." +"7.1.1.6","Contains two b-type cytochromes, two c-type cytochromes (cn and f), and a [2Fe-2S] Rieske cluster. The enzyme plays a key role in photosynthesis, transferring electrons from photosystem II (EC 1.10.3.9) to photosystem I (EC 1.97.1.12). Cytochrome c-552 can act as acceptor instead of plastocyanin, but more slowly. In chloroplasts, protons are translocated through the thylakoid membrane from the stroma to the lumen. The mechanism occurs through the Q cycle as in EC 7.1.1.8, quinol---cytochrome-c reductase (complex III) and involves electron bifurcation." +"7.1.1.7","This terminal oxidase enzyme is unable to pump protons but generates a proton motive force by transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water. The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) is 1. The bd-I oxidase from the bacterium Escherichia coli is the predominant respiratory oxygen reductase that functions under microaerophilic conditions in that organism. cf. EC 7.1.1.3, ubiquinol oxidase (H+-transporting)." +"7.1.1.8","The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. The mammalian enzyme contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin. Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non-cytoplasmic compartment [cf. EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating)]." +"7.2.1.3","A diheme cytochrome that transfers electrons across a single membrane, such as the outer membrane of the enterocyte, or the tonoplast membrane of the plant cell vacuole. Acts on hexacyanoferrate(III) and other ferric chelates." +"7.2.2.5","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of Mn2+, Zn2+ and iron chelates." +"7.2.2.6",A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A bacterial enzyme that is involved in K+ import. The probable stoichiometry is one ion per ATP hydrolysed. +"7.2.2.7","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains. A bacterial enzyme that interacts with a periplasmic iron-binding protein to imports Fe3+ ions into the cytoplasm." +"7.2.2.8","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme transports Cu+ or Ag+, and cannot transport the divalent ions, contrary to EC 7.2.2.9, P-type Cu2+ transporter, which mainly transports the divalent copper ion." +"7.2.2.9","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme from the termophilic archaeon Archaeoglobus fulgidus is involved in copper extrusion from the cell [1,2]." +"7.2.2.10","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme family comprises three types of Ca2+-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolysed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolysed. In muscle cells Ca2+ is transported from the cytosol (side 1) into the sarcoplasmic reticulum (side 2)." +"7.2.2.11","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of Ni2+; the identity of the nickel species transported has not been conclusively established. Does not undergo phosphorylation during the transport process." +"7.2.2.12","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, present in prokaryotes and photosynthetic eukaryotes, exports Zn2+ and the related cations Cd2+ and Pb2+." +"7.2.2.13","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential." +"7.2.2.14","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A bacterial enzyme that imports Mg2+ with, rather than against, the Mg2+ electrochemical gradient. The enzyme is also involved in Ni2+ import." +"7.2.2.15","A P-type ATPase that exports Ag+ ions from some bacteria, archaea as well as from some animal tissues. The proteins also transport Cu+ ions (cf. EC 7.2.2.8, P-type Cu+ transporter)." +"7.2.2.16","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of Fe3+-complexed hydroxamate siderophores such as coprogen, ferrichrome and the ferric hydroxamate antibiotic, albomycin." +"7.2.2.17","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of Fe3+-enterobactin complexes." +"7.2.2.18","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichia coli interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of Fe3+-citrate in the form of a mononuclear (containing one iron(III) ion and two citrate molecules) or dinuclear (containing 2 iron(III) ions) complexes." +"7.3.2.3","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichia coli can interact with either of two periplasmic binding proteins and mediates the high affinity uptake of sulfate and thiosulfate. May also be involved in the uptake of selenite, selenate and possibly molybdate. Does not undergo phosphorylation during the transport." +"7.3.2.4","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of nitrate, nitrite, and cyanate." +"7.3.2.5","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the high-affinity import of molybdate and tungstate. Does not undergo phosphorylation during the transport process." +"7.3.2.6","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, characterized from the archaeon Pyrococcus furiosus, the Gram-positive bacterium Eubacterium acidaminophilum and the Gram-negative bacterium Campylobacter jejuni, interacts with an extracytoplasmic substrate binding protein and mediates the import of tungstate into the cell for incorporation into tungsten-dependent enzymes." +"7.4.2.3","A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." +"7.4.2.4","A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. Involved in the transport of proteins or preproteins into chloroplast stroma (several ATPases may participate in this process)." +"7.4.2.5","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This entry stands for a family of bacterial enzymes that are dedicated to the secretion of one or several closely related proteins belonging to the toxin, protease and lipase families. Examples from Gram-negative bacteria include alpha-hemolysin, cyclolysin, colicin V and siderophores, while examples from Gram-positive bacteria include bacteriocin, subtilin, competence factor and pediocin." +"7.4.2.6","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of oligopeptides of varying nature. The binding protein determines the specificity of the system. cf. EC 7.4.2.9, ABC-type dipeptide transporter." +"7.4.2.7","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports the alpha-factor sex pheromone." +"7.4.2.8","A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is involved in protein transport. There are several families of enzymes included here, e.g. ATP-hydrolysing enzymes of the general secretory pathway (Sec or Type II), of the virulence-related secretory pathway (Type III) and of the conjugal DNA-protein transfer pathway (Type IV). Type II enzymes occur in bacteria, archaea and eucarya, whereas type III and type IV enzymes occur in bacteria where they form components of a multi-subunit complex." +"7.4.2.9","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of di- and tripeptides. The enzyme from Pseudomonas aeruginosa can interact with five different substrate binding proteins." +"7.5.2.3","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. An enzyme found in Gram-negative bacteria that exports beta-glucans." +"7.5.2.4","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. An enzyme found in Gram-positive bacteria that exports teichoic acid." +"7.5.2.5","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzyme, characterized from the bacterium Escherichia coli, functions as part of the lipopolysaccharide (LPS) export system, a seven protein system that translocates LPS from the inner- to the outer membrane. The ATPase activity in this system is implicated in releasing LPS from the inner membrane." +"7.5.2.6","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, best characterized from the bacterium Escherichia coli, is located in the inner membrane and mediates the movement of lipid A attached to the core oligosaccharide from the cytoplasm to the periplasmic side of the inner membrane, an important step in the lipopolysaccharide biosynthetic pathway. Not to be confused with EC 7.5.2.5, ABC-type lipopolysaccharide transporter (LptB), which is implicated in the translocation of LPS from the inner membrane to the outer membrane and acts later in the process." +"7.6.2.4","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome." +"7.6.2.5","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. The enzyme has been described from Gram-negative bacteria and green plants." +"7.6.2.6","An ATP-binding cassette (ABC) type transporter found in insects that transports guanine and other purines into pigment granules in the eye, where they are converted to pteridine pigments. The transporter is a hererodimer composed of two different peptides, each containing one membrane-spanning and one cytoplasmic ATP-binding domain. In Drosophila, this transporter is encoded by the white and brown genes." +"7.6.2.7","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of taurine. In Escherichia coli the enzyme imports a range of sulfonates (including taurine) that can be used as a source of sulfur." +"7.6.2.8","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives." +"7.6.2.9","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of quaternary amine derivatives." +"7.6.2.10","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of glycerol 3-phosphate and various glycerophosphodiesters." +"7.6.2.11","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports putrescine and spermidine. In Escherichia coli the enzyme imports spermidine preferentially. " +"4.1.1.114","The enzyme, found in certain bacterial species, catalyses the last step in a pathway for the production of olefins." +"1.1.1.416","The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.2.1.102, isopyridoxal dehydrogenase (5-pyridoxate-forming)." +"1.2.1.102","The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.1.1.416, isopyridoxal dehydrogenase (5-pyridoxolactone-forming)." +"1.14.14.166","This cytochrome P-450 (heme-thiolate) enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine." +"1.14.14.167","This cytochrome P-450 (heme-thiolate) enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine." +"1.14.14.168","A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower). The cyclisation of 8beta-hydroxygermacra-1(10),4,11(13)-triene-12-oate to inunolide (12,8beta) does not seem to occur spontaneously. The enzyme from Inula hupehensis also forms some 8alpha-hydroxygermacra-1(10),4,11(13)-triene-12-oate, which spontaneously cyclises to 8-epi-inunolide (12,8alpha) (cf. EC 1.14.14.170 8-epi-inunolide synthase)." +"1.14.14.169",A cytochrome P-450 (heme-thiolate) protein from the plant Helianthus annuus (common sunflower). +"1.14.14.170","A cytochrome P-450 (heme-thiolate) protein from the plant Inula hupehensis. The enzyme also produces 8beta-hydroxygermacra-1(10),4,11(13)-triene-12-oate (EC 1.14.14.168, germacrene A acid 8beta-hydroxylase)." +"1.14.19.76","A cytochrome P-450 (heme-thiolate) protein found in plants. The rice enzyme channels flavanones to the biosynthesis of tricin O-linked conjugates. cf. EC 1.14.20.5, flavone synthase I." +"1.21.4.5","The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, converts tetrachlorohydroquinone to 2,6-dichlorohydroquinone in two steps, via 2,3,6-trichlorohydroquinone, using glutathione as the reducing agent. The enzyme is sensitive to oxidation - when an internal L-cysteine residue is oxidized, the enzyme produces 2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone and 2,6-dichloro-3-(glutathion-S-yl)-hydroquinone instead of its normal products." +"2.1.1.351","The enzyme, isolated from the bacterium Saccharothrix syringae, is involved in the biosynthesis of nocamycin I and nocamycin II." +"2.1.1.352","This activity is part of the noscapine biosynthesis pathway, as characterized in the plant Papaver somniferum (opium poppy). It is catalysed by heterodimeric complexes of the OMT2 gene product and the product of either OMT3 or 6OMT. OMT2 is the catalytic subunit in both complexes." +"2.3.1.278","The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279, long-chain-acyl-CoA---trehalose acyltransferase), followed by the transfer of a mycolipenyl group to position 3." +"2.3.1.279","The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase)." +"2.3.1.280","The enzyme, characterized from the bacterium Escherichia coli, is able to acetylate a range of (aminoalkyl)phosphonic acids. Requires a divalent metal ion for activity." +"2.4.1.360","The enzyme has been characterized in Oryza sativa (rice), various Citrus spp., Glycine max (soybean), and Fagopyrum esculentum (buckwheat). Flavanone substrates require a 2-hydroxy group. The meta-stable flavanone substrates such as 2-hydroxynaringenin exist in an equilibrium with open forms such as 1-(4-hydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propane-1,3-dione, which are the actual substrates for the glucosyl-transfer reaction (see EC 1.14.14.162, flavanone 2-hydroxylase). The enzyme can also act on dihydrochalcones. The enzymes from citrus plants can catalyse a second C-glycosylation reaction at position 5." +"2.5.1.148","The enzyme, characterized from the green microalga Botryococcus braunii race L, in involved in biosynthesis of (14E,18E)-lycopadiene. In vitro, the enzyme can accept (2E,6E)-farnesyl diphosphate and phytyl diphosphate as substrates, and is also able to catalyse the condensation of two different substrate molecules, forming chimeric products. However, the use of these alternative substrates is not significant in vivo." +"2.5.1.149","The enzyme, characterized from the bacterium Corynebacterium glutamicum, is bifunctional. It catalyses the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2, as well as the hydroxylation of the new isoprene unit. The enzyme acts at both ends of the substrate, forming the C50 carotenoid flavuxanthin via the C45 intermediate nonaflavuxanthin. cf. EC 2.5.1.150, lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)." +"2.5.1.150","The enzyme, characterized from the bacterium Dietzia sp. CQ4 and the halophilic archaea Halobacterium salinarum and Haloarcula japonica, is bifunctional. It catalyses the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2 as well as the hydroxylation of the previous end of the molecule. The enzyme acts at both ends of the substrate, and combined with the action of EC 1.3.99.37, 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase, it forms the C50 carotenoid dihydrobisanhydrobacterioruberin. cf. EC 2.5.1.149, lycopene elongase/hydratase (flavuxanthin-forming)." +"2.5.1.151","This mammalian enzyme, which is cytosolic, can bind internalized methylcob(III)alamin and adenosylcob(III)alamin and process them to cob(I)alamin using the thiolate of glutathione for nucleophilic displacement. The product remains bound to the protein, and, following its oxidation to cob(II)alamin, is transferred by the enzyme, together with its interacting partner MMADHC, directly to downstream enzymes involved in adenosylcob(III)alamin and methylcob(III)alamin biosynthesis. In addition to its dealkylase function, the enzyme also catalyse an entirely different decyanase reaction with cyanocob(III)alamin (cf. EC 1.16.1.6, cyanocobalamin reductase)." +"4.2.3.198",The enzyme from the plant Ocimum basilicum (sweet basil) also produces beta-selinene while that from Liquidambar formosana (Formosan sweet gum) also produces traces of aromadendrene. +"4.2.3.199","The plant Salvia miltiorrhiza (danshen) produces three different forms of the enzyme, encoded by paralogous genes, that exhibit different spacial expression patterns and respond differently to hormone treatment." +"4.2.3.200",Isolated from the slime mould Dictyostelium discoideum. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. +"4.6.1.18","Specifically cleaves at the 3'-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA. The reaction takes place in two steps, with the 2',3'-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step. Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2'-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3',5'-phosphodiester bonds have been cyclised. The enzyme can act as an endo- or exo ribonuclease." +"4.6.1.19","A widely distributed family of related enzymes found in protozoans, plants, bacteria, animals and viruses that cleave ssRNA 3'-phosphate group with little base specificity. The enzyme catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending with a 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses the cyclic products in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides." +"4.6.1.20","The enzyme secreted by the fungus Ustilago sphaerogena cleaves at the 3'-phosphate group of purines, and catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides." +"4.6.1.21","Preference for cleavage at Cp-A bonds. Homopolymers of A, U or G are not hydrolysed. CpG bonds are hydrolysed less well and there is no detectable hydrolysis between two purines or two pyrimidines. The enzyme catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending a with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides." +"4.6.1.22","This enzyme catalyses endonucleolytic cleavage to 2',3'-cyclic nucleotides. The cyclic products may be hydrolysed to the corresponding 3'-phosphates by 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16). The enzyme from B. subtilis is inhibited by ATP." +"5.1.1.23","The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyses epimerization of the terminal L-glutamate in UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate. The reaction proceeds only in one direction and involves an adenylated intermediate. The combined activity of this enzyme and EC 6.3.2.53, UDP-N-acetylmuramoyl-L-alanine---L-glutamate ligase, provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3, glutamate racemase, and EC 6.3.2.9, UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase." +"5.6.1.2","A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa)." +"5.6.1.3","Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyse ATP. The enzymes described here move towards the plus end of the microtubule, in contrast to EC 5.6.1.2, dynein ATPase and EC 5.6.1.4, minus-end-directed kinesin ATPase. They are involved in organelle movement in mitosis and meiosis, and also power vesicular trafficking toward the synapse in neurons. The motor domain, which contains the ATP- and microtubule-binding activities, is located at the N-terminus while the C-terminus links to the cargo being transported." +"5.6.1.4","Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyse ATP and are involved in organelle movement. This enzyme is similar to EC 5.6.1.3, plus-end-directed kinesin ATPase, but the organization of the different domains differs, resulting in movement in the opposite direction along the microtubules." +"5.6.1.5","Belongs to the AAA-type superfamily and, like EC 5.6.1.4 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." +"5.6.1.6","ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. The enzyme is found in animals, and in humans its absence brings about cystic fibrosis. Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis. Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The enzyme is also involved in the functioning of other transmembrane channels." +"5.6.1.7","Multisubunit proteins with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or entry into mitochondria and chloroplasts. Molecular masses of subunits ranges from 10-90 kDa. They are a subclass of molecular chaperones that are related to EC 5.6.1.5 (proteasome ATPase)." +"5.6.1.8",Proteins of the contractile apparatus of muscle and nonmuscle cells; myosin molecule consists of two heavy chains (about 200 kDa) and two pairs of light chains (15--27 kDa). The head region of the heavy chain contains actin- and ATP-binding sites. ATP hydrolysis provides energy for actomyosin contraction. +"5.6.2.1","These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.2 DNA topoisomerase (ATP-hydrolysing)." +"5.6.2.2","The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.6.2.1 DNA topoisomerase)." +"6.3.2.53","The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyses the ligation of a terminal L-glutamate to UDP-N-acetyl-alpha-D-muramoyl-L-alanine. The combined activity of this enzyme and EC 5.1.1.23, UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase, provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3, glutamate racemase, and EC 6.3.2.9, UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase." +"7.2.2.19",A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed. +"7.2.4.4","Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. The enzyme described here is a membrane-bound biotin-dependent, Na+-translocating enzyme [6]. The other type is a biotin-independent cytosolic protein (cf. EC 4.1.1.88, biotin-independent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. Both enzymes achieve this by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-bound form of the enzyme. The ACP subunit of both enzymes differs from that found in fatty-acid biosynthesis by having phosphopantethine attached to a serine side-chain as 2-(5-triphosphoribosyl)-3-dephospho-CoA rather than as phosphopantetheine 4'-phosphate. In the anaerobic bacterium Malonomonas rubra, the components of the multienzyme complex/enzymes involved in carrying out the reactions of this enzyme are as follows: MadA (EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase), MadB (EC 7.2.4.1, carboxybiotin decarboxylase), MadC/MadD (EC 2.1.3.10, malonyl-S-ACP:biotin-protein carboxyltransferase) and MadH (EC 6.2.1.35, acetate---[acyl-carrier protein] ligase). Two other components that are involved are MadE, the acyl-carrier protein and MadF, the biotin protein. The carboxy group is lost with retention of configuration [5]. " +"7.6.2.12","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An enzyme that exports capsular polysaccharide in Gram-negative bacteria." +"1.13.11.88","Contains iron(II). The enzyme, charcterised from the bacteria Pseudomonas putida and Pseudomonas nitroreducens, catalyses the epoxidation of the double bond in the side chain of isoeugenol, followed by a second oxygenation and cleavage of the side chain in the form of acetaldehyde." +"1.14.11.61","Requires iron(II) and ascorbate. The product spontaneously undergoes trans-cis isomerization and lactonization to form scopoletin, liberating CoA in the process. The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-4-coumaroyl-CoA. cf. EC 1.14.11.62, trans-4-coumaroyl-CoA 2-hydroxylase." +"1.14.11.62","Requires iron(II) and ascorbate. The product spontaneously undergoes trans-cis isomerization followed by lactonization and cyclization, liberating CoA and forming umbelliferone. The enzymes from the plants Ruta graveolens and Ipomoea batatas also act on trans-feruloyl-CoA (cf. EC 1.14.11.61, feruloyl-CoA 6-hydroxylase)." +"1.14.11.63","Requires iron(II). The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2." +"1.14.13.243","The enzyme, characterized from the bacterium Burkholderia cepacia, belongs to a class of nonheme, oxygen-dependent diiron enzymes. It contains a hydroxylase component with two binuclear iron centers, an NADH-oxidoreductase component containing FAD and a [2Fe-2S] iron-sulfur cluster, and a third component involved in electron transfer between the hydroxylase and the reductase. The enzyme dihydroxylates its substrate in two sequential hydroxylations, initially forming 2-methylphenol, which is hydroxylated to 3-methylcatechol." +"1.14.13.244","The enzyme, characterized from the bacteria Pseudomonas sp. CF600 and Acinetobacter radioresistens, consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The reductase component is responsible for transferring electrons from NADH to the dinuclear iron center." +"1.14.13.245","The enzyme, studied from the bacterium Acinetobacter sp. strain 20B, is very similar to EC 1.14.13.244, phenol 2-monooxygenase (NADH). It consists of a multisubunit oxygenease component that contains the active site and a dinuclear iron center, a reductase component that contains FAD and one iron-sulfur cluster, and a regulatory component. The three components comprise five different polypeptides. The enzyme catalyses the first two steps of a dimethyl sulfide oxidation pathway in this organism." +"1.14.15.36","A cytochrome P-450 (heme-thiolate) protein found in several bacterial species. The enzyme, which is involved in sterol biosynthesis, catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond. The enzyme from Methylococcus capsulatus is fused to the ferredoxin by an alanine-rich linker. cf. EC 1.14.14.154, sterol 14alpha-demethylase." +"1.14.15.37","The enzyme, characterized from the bacterium Streptomyces thioluteus, is a bifunctional cytochrome P-450 (heme-thiolate) protein that catalyses both the hydroxylation of its substrate and formation of a furan ring, the final step in the biosynthesis of the antibiotic aureothin. In the bacteria Streptomyces orinoci and Streptomyces spectabilis an orthologous enzyme catalyses a similar reaction that forms spectinabilin." +"1.14.99.65","The enzyme, characterized from the bacterium Streptomyces venezuelae, participates in the biosynthesis of the antibiotic chloramphenicol. It carries an oxygen-bridged dinuclear iron cluster. The native electron donor remains unknown, and the enzyme was assayed in vitro using sodium dithionite. The enzyme only acts on its substrate when it is loaded onto the peptidyl-carrier domain of the CmlP non-ribosomal peptide synthase." +"2.1.1.353","The enzyme, characterized from the bacterium Streptomyces thioluteus, participates in the biosynthesis of the antibiotic aureothin. An orthologous enzyme in the bacteria Streptomyces orinoci and Streptomyces spectabilis catalyses a similar reaction in the biosynthesis of spectinabilin." +"2.3.1.281","This polyketide synthase enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), catalyses the first reaction in the biosynthesis of coelimycin P1. The enzyme is made of three proteins which together comprise six modules that contain a total of 28 domains. An NADH-dependent terminal reductase domain at the C-terminus of the enzyme catalyses the reductive release of the product." +"2.3.1.282","The enzyme, present in certain pathogenic species of mycobacteria, catalyses the transfer of mycocerosic acids to the two hydroxyl groups at the common lipid core of phthiocerol, phthiodiolone, and phenolphthiocerol, forming dimycocerosate esters. The fatty acid precursors of mycocerosic acids are activated by EC 6.2.1.49, long-chain fatty acid adenylyltransferase FadD28, which loads them onto EC 2.3.1.111, mycocerosate synthase. That enzyme extends the precursors to form mycocerosic acids that remain attached until transferred by EC 2.3.1.282." +"2.3.1.283","This mycobacterial enzyme catalyses the acylation of 2'-palmitoyl/stearoyl-2-O-sulfo-alpha,alpha-trehalose at the 3' position by a (hydroxy)phthioceranoyl group during the biosynthesis of mycobacterial sulfolipids." +"2.3.1.284","The enzyme, present in mycobacteria, catalyses the ultimate step in the biosynthesis of mycobacterial sulfolipids. It catalyses two successive transfers of a (hydroxy)phthioceranyl group from two diacylated intermediates to third diacylated intermediate, generating the tetraacylated sulfolipid." +"2.3.1.285","The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine." +"2.4.1.361","The enzyme from the hyperthermophilic bacterium Thermotoga maritima is involved in the synthesis of the solutes 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate and 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate." +"2.4.1.362",The enzyme from Leuconostoc spp. is responsible for producing alpha-(1->3) branches in alpha-(1->6) glucans by transferring the glucose residue from fructose to a 3-hydroxyl group of a glucan. +"2.5.1.152","The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt." +"2.6.1.115","The enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), participates in the biosynthesis of coelimycin P1, where it catalyses the amination of (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal. L-glutamate can also serve as the amino group donor with lower efficiency." +"2.7.1.225","The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of L-2,3-diaminopropanoate, which is used by that organism as a precursor for the biosynthesis of the siderophore staphyloferrin B." +"2.7.1.226","The enzyme, characterized in the hyperthermophilic archaeon Thermococcus kodakarensis, participates in L-cysteine biosynthesis." +"3.1.1.105","The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine." +"3.1.4.59","The enzyme, described from Gram-positive bacteria, degrades the second messenger cyclic di-3',5'-adenylate. It is a membrane-bound protein that contains a cytoplasmic facing Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1 domain, which confers the phosphodiesterase activity. Activity requires Mn2+ and is inhibited by pApA." +"3.1.4.60","The enzyme, characterized from the Gram-positive bacterium Staphylococcus aureus, is a cytoplasmic protein that contains a DHH/DHHA1 domain. It can act on cyclic di-3',5'-adenylate with a much lower activity (cf. EC 3.1.4.59, cyclic-di-AMP phosphodiesterase). Activity requires Mn2+ and is inhibited by ppGpp." +"3.5.1.131","The enzyme, characterized from the bacterium Pseudomonas sp. ADP, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazine herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is a heterotetramer composed of a catalytic subunit (AtzE) and an accessory subunit (AtzG) that stabilizes the complex." +"3.5.1.132","The enzyme participates in an L-arginine biosynthetic pathways in certain species of archaea and bacteria. In all cases known so far the enzyme also catalyses the activity of EC 3.5.1.130, [amino group carrier protein]-lysine hydrolase." +"4.1.1.116","The enzyme, characterized from the bacterium Salmonella typhimurium LT2, is specific for D-ornithine and D-lysine. Requires pyridoxal 5'-phosphate." +"4.1.1.117","The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the siderophore staphyloferrin B." +"4.2.99.24","Isolated from the plant Papaver somniferum (opium poppy). The reaction occurs spontaneously when the pH is between 8-9, but the enzyme is required at the physiological pH, which is close to 7." +"5.1.1.24","The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt." +"5.1.3.43","The enzyme is found in bacteria that possess sulfoglycolytic pathways. The enzyme can also act on other aldohexoses such as D-galactose, D-glucose, D-glucose-6-phosphate, and D-glucuronate, but with lower efficiency. Does not act on D-mannose." +"6.2.1.56","The enzyme, characterized from the marine ammonia-oxidizing archaeon Nitrosopumilus maritimus, participates in a variant of the 3-hydroxypropanoate/4-hydroxybutanate CO2 fixation cycle. cf. EC 6.2.1.40, 4-hydroxybutyrate---CoA ligase (AMP-forming)." +"6.3.2.54","Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation." +"6.3.2.55","Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS). Type C NIS enzymes recognize esterified or amidated derivatives of carboxylic acids. The enzyme likely forms a 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate adenylate intermediate prior to ligation." +"6.3.2.56","Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin B. It belongs to a class of siderophore synthases known as type B nonribosomal peptide synthase-independent synthases (NIS). Type B NIS enzymes recognize the delta-acid group of 2-oxoglutarate. The enzyme forms a 2-oxoglutarate adenylate intermediate prior to ligation." +"6.3.5.13","The enzyme complex, found in Gram-positive bacteria, consists of two subunits. A glutaminase subunit (cf. EC 3.5.1.2, glutaminase) produces an ammonia molecule that is channeled to a ligase subunit, which adds it to the activated D-glutamate residue of lipid II, converting it to an isoglutamine residue. " +"7.2.4.5","The enzyme from the bacterium Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme." +"1.1.1.417","This bacterial enzyme participates in the biosynthesis of bacterial sterols. Together with EC 1.14.13.246, 4beta-methylsterol monooxygenase (SdmA) it forms an enzyme system that removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules. SdmA catalyses three successive oxidations of the C-4beta methyl group, turning it into a carboxylate group; SdmB is a bifunctional enzyme that catalyses two different activities. As EC 1.1.1.417 it catalyses an oxidative decarboxylation that results in reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group. As EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, it reduces the 3-oxo group back to a 3beta-hydroxyl. Since the remaining methyl group at C-4 is in an alpha orientation, it cannot serve as a substrate for a second round of demethylation by this system." +"1.1.1.418","The enzyme, found in plants, catalyses multiple reactions during plant sterol biosynthesis. Unlike the fungal/animal enzyme EC 1.1.1.170, 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), the plant enzyme is specific for NAD+." +"1.14.13.246","Contains a Rieske [2Fe-2S] iron-sulfur cluster. This bacterial enzyme (SdmA) participates in the biosynthesis of bacterial sterols. Together with SdmB it forms an enzyme system that removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules. SdmA catalyses three successive oxidations of the C-4beta methyl group, turning it into a carboxylate group; the second enzyme, SdmB, is a bifunctional enzyme that catalyses two different activities. As EC 1.1.1.417, 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating), it catalyses an oxidative decarboxylation that results in reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group. As EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, it reduces the 3-oxo group back to a 3beta-hydroxyl. Unlike the animal/fungal enzyme EC 1.14.18.9, 4alpha-methylsterol monooxygenase, and the plant enzymes EC 1.14.18.10, plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase, and EC 1.14.18.11, plant 4alpha-monomethylsterol monooxygenase, this enzyme acts preferentially on the 4beta-methyl group. Since no epimerization of the remaining C-4alpha methyl group occurs, the enzyme can only remove one methyl group, leaving a 4alpha-monomethylated product. Known substrates include 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol and 14-demethyllanosterol." +"1.14.14.171",A cytochrome P-450 (heme-thiolate) protein isolated from the plant Maesa lanceolata (false assegai). Involved in the biosynthesis of maesasaponins. It also acts on some derivatives of beta-amyrin such as erythrodiol or oleanolic acid. +"1.14.18.10","This plant enzyme catalyses a step in the biosynthesis of sterols. It acts on the 4alpha-methyl group of the 4,4-dimethylated intermediate 24-methylidenecycloartanol and catalyses three successive oxidations, turning it into a carboxyl group. The carboxylate is subsequently removed by EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), which also catalyses the epimerization of the remaining 4beta-methyl into the 4alpha position. Unlike the fungal/animal enzyme EC 1.14.18.9, 4alpha-methylsterol monooxygenase, this enzyme is not able to remove the methyl group from C-4-monomethylated substrates. That activity is performed in plants by a second enzyme, EC 1.14.18.11, plant 4alpha-monomethylsterol monooxygenase." +"1.14.18.11","This plant enzyme catalyses a step in the biosynthesis of sterols. It acts on the methyl group of the 4alpha-methylated intermediates 24-ethylidenelophenol and 24-methylidenelophenol and catalyses three successive oxidations, turning it into a carboxyl group. The carboxylate is subsequently removed by EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating). Unlike the fungal/animal enzyme EC 1.14.18.9, 4alpha-methylsterol monooxygenase, this enzyme is not able to act on 4,4-dimethylated substrates. That activity, which occurs earlier in the pathway, is performed in plants by a second enzyme, EC 1.14.18.10, plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase." +"2.3.1.286","The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins. Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose." +"2.3.1.287","This mycobacterial polyketide enzyme produces the hepta- and octa-methylated fatty acids known as phthioceranic acids, and presumably their hydroxylated versions. Formation of hepta- and octamethylated products depends on whether the enzyme incorporates seven or eight methylmalonyl-CoA extender units, respectively. Formation of hydroxylated products may result from the enzyme skipping the dehydratase (DH) and enoylreductase (ER) domains during the first cycle of condensation [2]." +"2.4.1.363","The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the free C20(S)-OH group of dammarane derivative substrates, including protopanaxatriol, dammarenediol II, (20S)-ginsenoside Rh2, and (20S)-ginsenoside Rg3. It does not act on the 20R epimer of protopanaxadiol, or on ginsenosides that are glucosylated at the C-6 position, such as ginsenoside Rh1 or ginsenoside Rg2." +"2.4.1.364","The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the free C-3-OH group of (20S)-protopanaxadiol and ginsenoside C-K." +"2.4.1.365","The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the 2'' position of the glucose moiety in the protopanaxadiol-type ginsenoside-3-O-glucosides (20S)-ginsenoside Rh2 and ginsenoside F2." +"2.4.1.366","The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of ginsenoside F1. The enzyme also glucosylates the C-20 position of protopanaxatriol, which forms ginsenoside F1 (cf. EC 2.4.1.363, ginsenoside 20-O-glucosyltransferase). However, unlike EC 2.4.1.367, ginsenoside 6-O-glucosyltransferase, it is not able to glucosylate the C-6 position of protopanaxatriol when position C-20 is not glucosylated." +"2.4.1.367","The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of protopanaxatriol and ginsenoside F1. " +"2.4.1.368",The enzyme has been characterized from the saponin-producing crucifer plant Barbarea vulgaris. +"3.1.1.106","The enzyme, characterized from the bacterium Escherichia coli and from human cells, removes the acetyl group from either the 2'' or 3'' position of O-acetyl-ADP-ribose, which are formed by the action of EC 2.3.1.286, protein acetyllysine N-acetyltransferase. The human enzyme can also remove ADP-D-ribose from phosphorylated double stranded DNA adducts." +"3.7.1.24","Requires Zn2+. Isolated from the bacteria Pseudomonas fluorescens, Pseudomonas sp. YGJ3 and Mycobacterium abscessus 103. It reduces the antibiotic activity of 2,4-diacetylphloroglucinol." +"3.7.1.25",A bacterial enzyme that participates in the degradation of toluene and 2-nitrotoluene. +"4.2.3.201","Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrenol, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.202, hydropyrenol synthase, and EC 4.2.3.203, isoelisabethatriene synthase." +"4.2.3.202","Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrene, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.203, isoelisabethatriene synthase." +"4.2.3.203","Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is involved in a 1,3-hydride shift to the side-chain. The enzyme also produces hydropyrene, hydropyrenol, and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.202, hydropyrenol synthase." +"6.2.1.57","This mycobacterial enzyme activates palmitate and stearate by adenylation, followed by their loading onto the polyketide synthase EC 2.3.1.287, phthioceranic/hydroxyphthioceranic acid synthase." +"6.3.2.57","Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation." +"7.3.2.7","This bacterial transporter does not belong to the ABC superfamily, and instead is a member of its own family, referred to as the Ars family. The enzyme usually contains two subunits where one (with 12 membrane-spanning segments) forms the 'channel' part and the other (occurring in pairs peripherally to the membrane) contains the ATP-binding site. It forms an arsenite efflux pump that removes arsenite from the cytoplasm, and can also remove antimonite anions." +"7.4.2.10","A prokaryotic ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli is a heterotrimeric complex that interacts with an extracytoplasmic substrate binding protein to mediate the uptake of glutathione." +"7.4.2.11","ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and functions to import methionine. The enzyme from Escherichia coli K-12 mediates the high affinity transport of both L- and D-methionine, as well as methionine-S-oxide and N-acetyl-DL-methionine." +"7.4.2.12","ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine." +"7.5.2.7","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of D-ribose." +"7.5.2.8","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of D-allose, which can be used by the bacterium as a sole carbon source." +"7.5.2.9","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichai coli interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of D-galactofuranose. The periplasmic binding protein exhibits selective binding of D-galactofuranose over D-galactopyranose." +"7.5.2.10","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of D-xylose." +"7.5.2.11","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme, best characterized from Escherichia coli where it interacts with a periplasmic substrate binding protein and mediates the high affinity uptake of D-galactose and methyl-beta-D-galactoside." +"7.5.2.12","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high-affinity uptake of L-arabinose." +"7.5.2.13","ATP-binding cassette (ABC) type transporter with a 10-transmembrane-spanning (TMD) subunit and a single nucleotide binding domain. The enzyme from the archaeon Sulfolobus acidocaldarius interacts with an extracytoplasmic sugar-binding protein and mediates the uptake of of D-xylose and L-arabinose (cf. EC 7.5.2.10, ABC-type D-xylose transporter and EC 7.5.2.12, ABC-type L-arabinose transporter). " +"7.6.2.13","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of the signalling molecule (2R,4S)-2-methyl-2,3,3,4-tetrahydoxytetrahydrofuran (also known as autoinducer-2)." +"1.3.1.120","The enzyme, characterized from the bacterium Streptomyces collinus, is involved in a pathway that transforms shikimate to cyclohexane-1-carbonyl-CoA by a series of dehydration and double-bond reduction steps. Most of the steps in this process occur with the carboxylic acid activated as a coenzyme A thioester. The enzyme catalyses three steps in this pathway, also acting on (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA and (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA." +"1.3.98.5","The enzyme participates in a heme biosynthesis pathway found in Gram-positive bacteria. The initial decarboxylation step is fast and yields the three-propanoate harderoheme isomer III. The second decarboxylation is much slower. cf. EC 1.3.98.6, SAM-dependent heme synthase." +"1.3.98.6","This radical AdoMet enzyme participates in a heme biosynthesis pathway found in archaea and sulfur-reducing bacteria. cf. EC 1.3.98.5, hydrogen peroxide-dependent heme synthase." +"1.8.1.21","The enzyme's activity has been demonstrated in the bacterium Thiobacillus thioparus E6. The methanethiol formed is eventually oxidized to sulfate and carbon dioxide, and the latter assimilated for autotrophic growth." +"1.13.11.89","Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway. It also has the activity of EC 1.13.11.78, (2-amino-1-hydroxyethyl)phosphonate dioxygenase (glycine-forming)." +"1.14.11.64","Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates." +"1.14.11.65","Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the di- and mono-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.66, [histone H3]-trimethyl-L-lysine9 demethylase." +"1.14.11.66","Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.65, [histone H3]-dimethyl-L-lysine9 demethylase." +"1.14.11.67","Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 4 of histone H3 (H3K4). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri-, di-, and mono-methylated forms." +"1.14.11.68","Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form." +"1.14.11.69","Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys36 residues in the tail of the histone protein H3 (H3K36). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. Since trimethylation of H3K36 enhances transcription, this enzyme acts as a transcription repressor. The enzymes that possess this activity often also catalyse the activity of EC 1.14.11.66, [histone H3]-trimethyl-L-lysine9 demethylase. cf. EC 1.14.11.27, [histone H3]-dimethyl-L-lysine36 demethylase." +"1.14.99.66","The enzyme specifically removes methyl groups from mono- and dimethylated lysine4 of histone 3. During the reaction the substrate is oxidized by the FAD cofactor of the enzyme to generate the corresponding imine, which is subsequently hydrolysed in the form of formaldehyde.The enzyme is similar to flavin amine oxidases, and differs from all other known histone lysine demethylases, which are iron(II)- and 2-oxoglutarate-dependent dioxygenases. The physiological electron acceptor is not known with certainty. In vitro the enzyme can use oxygen, which is reduced to hydrogen peroxide, but generation of hydrogen peroxide in the chromatin environment is unlikely as it will result in oxidative damage of DNA." +"2.1.1.354","This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. EC 2.1.1.364, [histone H3]-lysine4 N-methyltransferase, describes enzymes that can catalyse only monomethylation of this substrate (the first sub-reaction of this entry); EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase, describes enzymes that catalyse only dimethylation of this substrate (the first two sub-reactions of this entry)" +"2.1.1.355","This entry describes several enzymes that successively methylate the L-lysine9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, and EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase." +"2.1.1.356","This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. The methylation of lysine27 leads to transcriptional repression of the affected target genes. The enzyme associates with other proteins to form a complex that is essential for activity. The enzyme can also methylate some non-histone proteins. cf. EC 2.1.1.369, [histone H3]-lysine27 N-methyltransferase and EC 2.1.1.371, [histone H3]-lysine27 N-dimethyltransferase." +"2.1.1.357","This entry describes a group of metazoan enzymes that catalyse two successive methylations of lysine36 of histone H3 (H3K36), forming mono- and dimethylated forms. These modifications influence the binding of chromatin-associated proteins. Some enzymes can catalyse three methylations, forming a trimethylated form; these enzymes are classified under EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase." +"2.1.1.358","The enzyme, found in metazoa, methylates a dimethylated L-lysine36 residue of histone H3 (H3K36), which has been methylated previously by EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase. The homologous enzyme from yeast catalyses all three methylations (see EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase)." +"2.1.1.359","The enzyme, characterized from yeast and mammals, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. cf. EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase." +"2.1.1.360","The enzyme successively methylates the L-lysine79 residue of histone H3 (H3K79), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. This is the only known methylation event of a lysine residue within the core region of a histone, as all other such modifications occur at the tail." +"2.1.1.361","The enzyme catalyses the monomethylation of the L-lysine20 residue of histone H4 (H4K20). This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase. This enzyme plays a pivotal role in DNA replication. Activity is high during the G2 and M phases, but declines significantly during G1 and S phases. Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation." +"2.1.1.362","This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine20 of histone H4 (H4K20m1, generated by EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine20 in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated." +"2.3.1.288","This mycobacterial enzyme catalyses the acylation of 2-O-sulfo-alpha,alpha-trehalose at the 2' position by a C16 or C18 fatty acyl group during the biosynthesis of mycobacterial sulfolipids." +"2.3.1.289","This polyketide synthase, characterized from the bacterium Streptomyces thioluteus, generates the backbone of the antibiotic aureothin. It is composed of 4 modules that total 18 domains and is encoded by three genes. The enzyme accepts the unusual starter unit 4-nitrobenzoyl-CoA and extends it by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalysed by only four modules. The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric)." +"2.3.1.290","This polyketide synthase, characterized from the bacteria Streptomyces orinoci and Streptomyces spectabilis, generates the backbone of the antibiotic spectinabilin. It is composed of 6 modules that total 28 domains and is encoded by four genes. The enzyme accepts the unusual starter unit 4-nitrobenzoyl-CoA and extends it by 6 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by norA) is used twice in an iterative fashion, so that the seven Claisen condensation reactions are catalysed by only six modules. The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric)." +"2.3.1.291","Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine." +"2.4.1.369","The enzyme, found in pathogenic strains of the bacteria Escherichia coli and Salmonella enterica, catalyses the transfer of glucosyl groups to C-5 of one, two, or three of the 2,3-hydroxybenzoyl units of the siderophore enterobactin, forming C-glucosylated derivatives known as salmochelins." +"2.4.1.370","The simplest complex sphingolipid of yeast, inositol-phospho-alpha-hydroxyphytoceramide (IPC), is usually mannosylated to yield mannosyl-inositol-phospho-alpha hydroxyphytoceramide (MIPC). The enzyme is located in the Golgi apparatus, and utilizes GDP-mannose as the mannosyl group donor. It consists of a catalytic subunit (SUR1 or CSH1) and a regulatory subunit (CSG2)." +"3.1.1.107","This bacterial enzyme is present in pathogenic Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. Unlike EC 3.1.1.108, iron(III)-enterobactin esterase, which acts only on enterobactin, this enzyme can also act on the C-glucosylated forms known as salmochelins. Unlike EC 3.1.1.109, iron(III)-salmochelin esterase (IroD), IroE prefers apo siderophores as substrates, and is assumed to act before the siderophores are exported out of the cell. It hydrolyses the trilactone only once, producing linearized trimers." +"3.1.1.108","The enzyme, isolated from the bacterium Escherichia coli, allows the bacterium to grow in limited iron conditions. It can also act on enterobactin (with no complexed iron) and the aluminium(III) analogue of iron(III)-enterobactin. The trimer formed is further hydrolysed to form the dimer and the monomer." +"3.1.1.109","This bacterial enzyme is present in pathogenic Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. The enzyme acts on iron(III)-bound enterobactin and C-glucosylated derivatives known as salmochelins. Unlike EC 3.1.1.107, apo-salmochelin esterase (IroE), IroD prefers iron(III)-bound siderophores as substrates, and is assumed to act after the iron-siderophore complexes are imported into the cell. It catalyses several hydrolytic reactions, producing a mixture of iron(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] complex and salmochelin SX." +"3.1.3.106","The enzyme has been studied from the plants Arachis hypogaea (peanut) and Arabidopsis thaliana (thale cress) and from the yeast Saccharomyces cerevisiae. The enzyme from yeast, but not from the plants, requires Mg2+." +"3.2.1.209","The enzyme, located in the endoplasmic reticulum, primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 isomer 8A1,2,3B1,3 (the names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7]). The removal of the single mannosyl residue occurs in all eukaryotes as part of the processing of N-glycosylated proteins, and is absolutely essential for further elongation of the outer chain of properly-folded N-glycosylated proteins in yeast. In addition, the enzyme is involved in glycoprotein quality control at the ER quality control compartment (ERQC), helping to target misfolded glycoproteins for degradation. When present at very high concentrations in the ERQC, the enzyme can trim the carbohydrate chain further to Man(5-6)GlcNAc2." +"3.5.1.133","Requires Zn2+. The enzyme, characterized from the bacterium Corynebacterium sp. Ax20, hydrolyses odorless Nalpha-acyl-L-glutamine conjugates of short- and medium-chain fatty acids, releasing axillary malodor compounds. While the enzyme is highly specific for the L-glutamine moiety, it is quite promiscuous regarding the acyl moiety. The two most common products of the enzyme's activity in axillary secretions are (2E)-3-methylhex-2-enoate and 3-hydroxy-3-methylhexanoate." +"4.2.3.204","The enzyme was characterized from the trees Camellia hiemalis and Camellia sinensis (black tea). The enzyme from Camellia hiemalis produces (2Z,6E)-hedycaryol as a minor product." +"6.3.2.58","Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation." +"7.2.2.20","ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high-affinity import of Zn2+." +"7.6.2.14","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli K-12 interacts with an extracytoplasmic substrate binding protein and imports a broad range of aliphatic sulfonates for use as a source of sulfur." +"7.6.2.15","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, characterized from the bacterium Salmonella typhimurium, is a heterodimeric complex that interacts with an extracytoplasmic substrate binding protein and functions to import thiamine, thiamine monophosphate and thiamine diphosphate." +"7.6.2.16","ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of putrescine. Differs in specificity from EC 7.6.2.11, ABC-type polyamine transporter." +"1.1.1.419","The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. It also catalyses the activity of EC 5.5.1.34, (+)-cis,trans-nepetalactol synthase." +"1.1.5.13","The enzyme, characterized from the bacterium Escherichia coli, contains an FAD cofactor that is not covalently attached. It is bound to the cytoplasmic membrane and is coupled to the membrane quinone pool." +"2.1.4.3","The enzyme, characterized from the bacterium Pseudomonas savastanoi pv. phaseolicola, is involved in the biosynthesis of the toxin phaseolotoxin, a modified tripeptide that causes the 'halo blight' disease of beans." +"2.3.1.292","The enzyme, which is a complex of five polyketide synthase proteins, is involved in the synthesis of the lipid core common to phthiocerols and phenolphthiocerols. The first protein, PpsA, can accept either a C18 or C20 long-chain fatty acyl, or a (4-hydroxyphenyl)-C17 or C19 fatty acyl. The substrates must first be adenylated by EC 6.2.1.59, long-chain fatty acid adenylase/transferase FadD26, which also loads them onto PpsA. PpsA then extends them using a malonyl-CoA extender unit. The PpsB protein adds the next malonyl-CoA extender unit. The absence of a dehydratase and an enoyl reductase domains in the PpsA and PpsB modules results in the formation of the diol portion of the phthiocerol moiety. PpsC adds a third malonyl unit (releasing a water molecule due to its dehydratase domain), PpsD adds an (R)-methylmalonyl unit, releasing a water molecule, and PpsE adds a second (R)-methylmalonyl unit, without releasing a water molecule. The incorporation of the methylmalonyl units results in formation of two branched methyl groups in the elongated product. The enzyme does not contain a thioesterase domain [2], and release of the products requires the tesA-encoded type II thioesterase [1]." +"2.3.1.293","The enzyme is part of the fatty acid synthase (FAS) II system of mycobacteria, which extends modified products of the FAS I system, eventually forming meromycolic acids that are incorporated into mycolic acids. Meromycolic acids consist of a long chain, typically 50-60 carbons, which is functionalized by different groups.Two 3-oxoacyl-(acyl carrier protein) synthases function within the FAS II system, encoded by the kasA and kasB genes. The two enzymes share some sequence identity but function independently on separate sets of substrates. KasA differs from KasB [EC 2.3.1.294, meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II], by preferring shorter (C-22 to C-36) and more saturated (only one double bond) substrates." +"2.3.1.294","The enzyme is part of the fatty acid synthase (FAS) II system of mycobacteria, which extends modified products of the FAS I system, eventually forming meromycolic acids that are incorporated into mycolic acids. Meromycolic acids consist of a long chain, typically 50-60 carbons, which is functionalized by different groups.Two 3-oxoacyl-(acyl carrier protein) synthases function within the FAS II system, encoded by the kasA and kasB genes. The two enzymes share some sequence identity but function independently on separate sets of substrates. KasB differs from KasA (EC 2.3.1.293, meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I), by preferring longer substrates (closer to the upper limit), which also contain two double bonds." +"2.3.1.295","The enzyme, found in mycobacteria, is involved in the synthesis of beta-D-mannosyl phosphomycoketides. It is a very large polyketide synthase that contains two complete sets of FAS-like fatty acid synthase modules. It binds an acyl-CoA with 5-9 carbons as a starter unit, and extends it by five rounds of alternative additions of malonyl-CoA and methylmalonyl-CoA extender units. Depending on the starter unit, the enzyme forms mycoketide-CoAs of different lengths." +"2.3.1.296","The enzyme participates in the production of acylceramides in the stratum corneum, the outermost layer of the epidermis. Acylceramides are crucial components of the skin permeability barrier." +"2.3.1.297","This entry describes ceramide synthase enzymes that are specific for very-long-chain fatty acyl-CoA substrates. The two isoforms from yeast and the plant LOH1 and LOH3 isoforms transfer 24:0 and 26:0 acyl chains preferentially and use phytosphingosine as the preferred sphingoid base. The mammalian CERS2 isoform is specific for acyl donors of 20-26 carbons, which can be saturated or unsaturated. The mammalian CERS3 isoform catalyses this activity, but has a broader substrate range and also catalyses the activity of EC 2.3.1.298, ultra-long-chain ceramide synthase. Both mammalian enzymes can use multiple sphingoid bases, including sphinganine, sphingosine, and phytosphingosine." +"2.3.1.298","Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 3 (CERS3) is the only enzyme that is active with ultra-long-chain acyl-CoA donors (C28 or longer). It is active in the epidermis, where its products are incorporated into acylceramides. CERS3 also accepts (2R)-2-hydroxy fatty acids and omega-hydroxy fatty acids, and can accept very-long-chain acyl-CoA substrates (see EC 2.3.1.297, very-long-chain ceramide synthase). It can use multiple sphingoid bases including sphinganine, sphingosine, phytosphingosine, and (6R)-6-hydroxysphingosine." +"2.3.1.299","Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 1 (CERS1) is structurally and functionally distinctive from all other CERS enzymes, and is specific for stearoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine." +"2.6.1.116","The enzyme, characterized from the bacterium Arthrobacter sp. KI72, participates in the degradation of nylon-6. Glyoxylate can serve as an alternative amino group acceptor with similar efficiency." +"2.6.1.117","A pyridoxal-phosphate protein. The enzyme, found in both prokaryotes and eukaryotes, catalyses the last reaction in a methionine salvage pathway. In mammals this activity is catalysed by the multifunctional glutamine transaminase K (cf. EC 2.6.1.64, glutamine---phenylpyruvate transaminase)." +"2.7.1.227","The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to alpha-hydroxyphytoceramides, generating a very-long-chain inositol phospho-alpha hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast." +"2.7.1.228","This enzyme catalyses the ultimate reaction in the yeast sphingolipid biosynthesis pathway. It transfers a second phosphoinositol group to mannosyl-inositol-phospho-alpha-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C)." +"2.7.1.229","The enzyme, characterized from bacteria, is much more active with 2-deoxy-D-ribose than with D-ribose. cf. EC 2.7.1.15, ribokinase." +"2.8.1.16","The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea." +"3.1.1.110","The enzyme, found in bacteria, participates in the degradation of D-xylose. cf. EC 3.1.1.68, xylono-1,4-lactonase." +"3.1.1.111","The enzyme, which has been described from mammals, is specific for phosphatidylserine and 2-lysophosphatidylserine, and does not act on phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid or phosphatidylinositol." +"3.1.1.112","The enzyme, characterized from the yeast Saccharomyces cerevisiae, hydrolyses acetate esters. It acts preferentially on 3-methylbutyl acetate, a major determinant of sake flavor." +"3.1.1.113","The enzyme, characterized from Pseudomonas strains, is involved in degradation of short chain alkyl methyl ketones." +"3.1.1.114","The enzyme, characterized from the bacterium Gordonia sp. TY-5, participates in a propane utilization pathway." +"3.2.1.210","In yeast this activity is catalysed by a dedicated enzyme that processes unfolded protein-bound Man8GlcNAc2 N-glycans within the endoplasmic reticulum to Man7GlcNAc2. The exposed alpha-1,6-linked mannose residue in the product enables the recognition by the YOS9 lectin, targeting the proteins for degradation. In mammalian cells this activity is part of the regular processing of N-glycosylated proteins, and is not associated with protein degradation. It is carried out by EC 3.2.1.113, Golgi mannosyl-oligosaccharide 1,2-alpha-mannosidase. The names of the isomers listed here are based on a nomenclature system proposed by Prien et al [5]." +"3.4.13.23","The enzyme participates in a widespread glutathione-mediated detoxification pathway. In animals the activity is usually catalysed by enzymes that have numerous additional activities, such as EC 3.4.11.1, leucyl aminopeptidase, EC 3.4.11.2, membrane alanyl aminopeptidase, and EC 3.4.13.19, membrane dipeptidase. However, in the bacterium Corynebacterium sp. Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task." +"3.5.1.134","The enzyme, isolated from the bacterium Pantoea agglomerans, is specific for its substrate and does not act efficiently on other indole-3-acetate conjugates." +"4.1.1.118","The enzyme, characterized from the bacterium Syntrophorhabdus aromaticivorans, participates in an anaerobic isophthalate degradation pathway. The enzyme requires a prenylated flavin mononucleotide cofactor." +"4.2.1.175","The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It is a heterodimeric protein consisting of the FldB and FldC polypeptides, both of which contain an [4Fe-4S] cluster, and forms a complex with EC 2.8.3.17, 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase (FldA). In order to catalyse the reaction, the enzyme requires one high-energy electron that transiently reduces the electrophilic thiol ester carbonyl of the substrate to a nucleophilic ketyl radical anion, facilitating the elimination of the hydroxyl group. This electron, which is provided by by EC 5.6.1.9, (R)-2-hydroxyacyl-CoA dehydratase activating ATPase, needs to be supplied only once, before the first reaction takes place, as it is regenerated at the end of each reaction cycle. The enzyme acts on (R)-3-(aryl)lactoyl-CoAs produced by FldA, and regenerates the CoA donors used by that enzyme." +"4.2.3.205",The enzyme has been characterized from the bacterium Serratia plymuthica. +"4.6.1.23","Ribotoxins are rRNA endonucleases that catalyse the cleavage of the phosphodiester bond between guanosine and adenosine residues at one specific position in 28S rRNA. The enzyme secreted by Aspergillus giganteus specifically cleaves rat 28S rRNA between G4325 and A4326 and displays cytotoxic activity toward animal cells. It can also act on bacterial rRNAs. The enzyme catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides." +"5.4.99.67","The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 5.4.99.5, chorismate mutase." +"5.6.1.9","Members of the (R)-2-hydroxyacyl-CoA dehydratase family (including EC 4.2.1.54, lactoyl-CoA dehydratase, EC 4.2.1.157, (R)-2-hydroxyisocaproyl-CoA dehydratase, EC 4.2.1.167, (R)-2-hydroxyglutaryl-CoA dehydratase and EC 4.2.1.175, (R)-3-(aryl)lactoyl-CoA dehydratase) are two-component systems composed of an activator component and a dehydratase component. The activator is an extremely oxygen-sensitive homodimer with one [4Fe-4S] cluster bound at the dimer interface. Before it can catalyse the dehydration reaction, the dehydratase requires one high-energy electron that is used to transiently reduce the electrophilic thiol ester carbonyl to a nucleophilic ketyl radical anion, facilitating the elimination of the hydroxyl group. The activator, which has been named archerase because its open position resembles an archer shooting arrows, binds two ADP molecules. Upon the reduction of its [4Fe-4S] cluster by a single electron, delivered by a dedicated flavodoxin or a clostridial ferredoxin, the two ADP molecules exchange for two ATP molecules, resulting in a large conformational change. The change allows the activator to bind to the dehydratase component and transfer the electron to it, activating it. During this event the two ATP molecules are hydrolysed and the activator returns to its resting state. Since the electron is regenerated at the end of each reaction cycle of the dehydratase, the activation is required only once, before the first reaction takes place." +"6.2.1.58","The enzyme, characterized from the bacterium Syntrophorhabdus aromaticivorans, catalyses the first step in an anaerobic isophthalate degradation pathway." +"6.2.1.59","The enzyme, present in pathogenic species of mycobacteria, participates in the pathway for biosynthesis of phthiocerols. It catalyses the adenylation of the long-chain fatty acids arachidate (C20) or behenate (C22) [1] and potentially the very-long-chain fatty acid lignocerate (C24) [2]. The activated fatty acids are then loaded to EC 2.3.1.292, (phenol)carboxyphthiodiolenone synthase." +"6.2.1.60","The enzyme, characterized from the bacterium Pseudoalteromonas sp. SANK 73390, catalyses the CoA acylation of pseudomonic and marinolic acids, as part of the biosynthesis of thiomarinols and related compounds." +"7.2.2.21","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants." +"1.1.1.420","The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose." +"1.1.1.421","The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. The reaction involves migration of a hydroxymethyl group from position 3 to position 2 and oxidation of the 3-hydroxyl group. Stereospecificity of the product, 3-oxoisoapionate, has not been determined." +"1.1.2.10","Isolated from the bacterium Methylacidiphilum fumariolicum and many Methylobacterium species. Requires La3+, Ce3+, Pr3+ or Nd3+. The higher lanthanides show decreasing activity with Sm3+, Eu3+ and Gd3+. The lanthanide is coordinated by the enzyme and pyrroloquinoline quinone. Shows little activity with Ca2+, the required cofactor of EC 1.1.2.7, methanol dehydrogenase (cytochrome c)." +"1.2.1.103",The enzyme participates in an L-lysine biosynthesis in certain species of archaea and bacteria. +"1.3.1.121","The enzyme, characterized from the bacteria Streptomyces venezuelae and Streptomyces pristinaespiralis, participates in the biosynthesis of the antibiotics chloramphenicol and pristinamycin IA, respectively. cf. EC 1.3.1.12, prephenate dehydrogenase." +"1.3.1.122","Isolated from the plants Catharanthus roseus, Olea europaea (common olive), and several Nepeta species. The enzyme reduces 8-oxogeranial, generating an unstable product that is subsequently cyclized into several possible products, either non-enzymically or by dedicated cyclases. The products, known as iridoids, are involved in the biosynthesis of many indole alkaloids. cf. EC 1.3.1.123, 7-epi-iridoid synthase." +"1.3.1.123","The enzyme, characterized from the plant Antirrhinum majus (snapdragon), is involved in biosynthesis of 7-epi-iridoids such as antirrhinoside. The enzyme catalyses the stereospecific reduction of 8-oxogeranial, forming an unstable product that in the absence of additional cylases undergoes spontaneous cyclization to (-)-cis,trans-nepetalactol. cf. EC 1.3.1.122, (S)-8-oxocitronellyl enol synthase." +"1.3.8.15","The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. Unlike EC 1.3.1.31, 2-enoate reductase, this enzyme has minimal activity with crotonate." +"1.8.4.15","DsbA is a periplasmic thiol:disulfide oxidoreductase found in Gram-negative bacteria that promotes protein disulfide bond formation. DsbA contains a redox active disulfide bond that is catalytically transferred via disulfide exchange to a diverse range of newly translocated protein substrates. The protein is restored to the oxidized state by EC 1.8.5.9, protein dithiol:quinone oxidoreductase DsbB." +"1.8.4.16","The DsbD protein is found in Gram-negative bacteria and transfers electrons from cytoplasmic thioredoxin to the periplasmic substrate proteins DsbC, DsbG and CcmG, reducing disulfide bonds in the target proteins to dithiols. NrdH redoxins, which are found in Gram-positive bacteria, catalyse a similar reaction." +"1.8.5.9","DsbB is a protein found in Gram-negative bacteria that functions within a pathway for protein disulfide bond formation. The enzyme catalyses the oxidation of the DsbA protein by generating disulfide bonds de novo via the reduction of membrane quinones. cf. EC 1.8.4.15, protein dithiol oxidoreductase (disulfide-forming)." +"1.10.3.17","This membrane-bound, di-heme containing enzyme, identified in the bacterium Escherichia coli, is responsible for the detoxification of superoxide in the periplasm. In vivo the reaction proceeds in the opposite direction of that shown and produces oxygen. Superoxide production was only observed when the enzyme was incubated in vitro with an excess of ubiquinol." +"1.14.11.70","Requires iron(II). The enzyme, found in some cyanobacterial species, catalyses the last step in the biosynthesis of the toxins cylindrospermopsin and 7-epi-cylindrospermopsin. The ratio of the two products differs among different strains." +"1.14.11.71","Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway." +"1.14.13.247","The enzyme, characterized from the bacterium Sinorhizobium meliloti 1021, consists of three different types of subunits. The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyses the monooxygenation of a methyl group. The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde. The other subunits are involved in the transfer of electrons from NAD(P)H to the catalytic subunit." +"2.1.1.363","The enzyme, characterized from the bacterium Serratia plymuthica, participates in biosynthesis of sodorifen." +"2.3.2.33","RCR-type E3 ubiquitin transferases is a class of RING-type E3 ubiquitin transferase (see EC 2.3.2.27) that mediates ubiquitylation of acceptor proteins via an internal cysteine residue. The RING1 domain binds an EC 2.3.2.23, E2 ubiquitin-conjugating enzyme, and transfers the ubiquitin that is bound to it to an internal cysteine residue on a mediator loop of the RCR-type ligase. The ubiquitin may be transferred to a second internal cysteine before the transfer of the ubiquitin from the RCR-type ligase to the substrate." +"2.4.1.371","The enzyme is involved in the biosynthesis of polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a. The enzymes consists of two domains that are responsible for the 1->2 and 1->3 linkages, respectively." +"2.4.1.372","The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends the glucan chain by an alpha(1->3) linkage." +"2.4.1.373","The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme introduces alpha(1->2) branches into (1->6)-alpha-D-glucans." +"2.4.1.374","The enzyme, characterized from Leishmania parasites, is involved in synthesis of mannogen, a beta-(1->2)-mannan oligosaccharide used by the organisms as a carbohydrate reserve." +"2.6.1.118",The enzyme participates in an L-lysine biosynthesis pathway in certain species of archaea and bacteria. +"2.7.1.230","The enzyme, found in some bacterial species, inactivates the antibiotic amicoumacin A by phosphorylating it, conferring resistance on the bacteria." +"2.7.2.16","The enzyme, found in a number of methanogenic archaeal genera, is involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant. Activity is stimulated by potassium ions." +"3.1.3.107","This bacterial enzyme activates the antibiotic amicoumacin A by removing a phosphate group that is added by EC 2.7.1.230, amicoumacin kinase." +"3.6.1.69","The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 3.6.1.55, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 3.6.1.58, 8-oxo-dGDP phosphatase." +"3.6.1.70","Aprataxin is a DNA-binding protein that catalyses (among other activities) the 5' decapping of Gpp-DNA (formed by homologs of RtcB3 from the bacterium Myxococcus xanthus). The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and eventual release. The enzyme forms a 5'-phospho terminus that can be efficiently joined by ""classical"" ligases. The enzyme also possesses the activitiy of EC 3.6.1.71, adenosine-5'-diphospho-5'-[DNA] diphosphatase and EC 3.6.1.72, DNA-3'-diphospho-5'-guanosine diphosphatase. " +"3.6.1.71","Aprataxin is a DNA-binding protein involved in different types of DNA break repair. The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus. It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, ribonuclease H, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction. Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined. The enzyme also possesses the activities of EC 3.6.1.70, guanosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.6.1.72, DNA-3'-diphospho-5'-guanosine diphosphatase." +"3.6.1.72","Aprataxin is a DNA-binding protein that catalyses (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8, 3'-phosphate/5'-hydroxy nucleic acid ligase) [1]. The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release. The enzyme also possesses the activity of EC 3.6.1.71, adenosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.6.1.70, guanosine-5'-diphospho-5'-[DNA] diphosphatase." +"4.1.1.119","This bacterial enzyme, isolated from anoxic, toluene-producing microbial communities, is a glycyl radical enzyme. It needs to be activated by a dedicated activating enzyme (PhdA). The activase catalyses the reductive cleavage of AdoMet, producing a 5'-deoxyadenosyl radical that leads to the production of the glycyl radical in PhdB." +"5.5.1.34","The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. The product is a precursor of (+)-cis,trans-nepetalactone, the primary ingredient responsible for the psychoactive effects catnip has on cats." +"5.5.1.35","The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. The product is a precursor of (+)-cis,cis-nepetalactone, one of the stereoisomers responsible for the psychoactive effects catnip has on cats." +"6.2.1.61","The enzyme catalyses the activation of salicylate to (salicyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein, which is often a domain of a larger non-ribosimal peptide synthase. The PmsE enzyme is involved in pseudomonine biosynthesis and transfers the activated salicylate first to itself, and then to a PmsG protein. The PchD enzyme is involved in pyochelin biosynthesis and transfers the activated salicylate directly to the PchE protein." +"7.1.1.9","An oligomeric membrane heme-Cu:O2 reductase-type enzyme that terminates the respiratory chains of aerobic and facultative aerobic organisms. The reduction of O2 to water is accompanied by the extrusion of four protons. The cytochrome-aa3 enzymes of mitochondria and many bacterial species are the most abundant group, but other variations, such as the bacterial cytochrome-cbb3 enzymes, also exist. All of the variants have a conserved catalytic core subunit (subunit I) that contains a low-spin heme (of a- or b-type), a binuclear metal centre composed of a high-spin heme iron (of a-, o-, or b-type heme, referred to as a3, o3 or b3 heme), and a Cu atom (CuB). Besides subunit I, the enzyme usually has at least two other core subunits: subunit II is the primary electron acceptor; subunit III usually does not contain any cofactors, but in the case of cbb3-type enzymes it is a diheme c-type cytochrome. While most bacterial enzymes consist of only 3--4 subunits, the mitochondrial enzyme is much more complex and contains 14 subunits." +"7.4.2.13","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, found in Clostridioides, interacts with an extracytoplasmic substrate binding lipoprotein and mediates the import of L-tyrosine. L-phenylalanine is also tranported however with lower efficiency." +"1.1.1.422","The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. The enzyme exhibits a strict anti-Prelog enantioselectivity. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC 1.1.1.423, ephedrine dehydrogenase." +"1.1.1.423","The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It exhibits a strict enantioselectivity and accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. cf. EC 1.1.1.422, pseudoephedrine dehydrogenase and EC 1.5.1.18, ephedrine dehydrogenase." +"1.1.98.7","A bacterial radical S-adenosyl-L-methionine (AdoMet) enzyme that contains three [4Fe-4S] clusters. The enzyme, found in some bacteria, activates a type I sulfatase enzyme (EC 3.1.6.1) by converting a conserved L-serine residue in the active site to a unique 3-oxo-L-alanine residue that is essential for the sulfatase activity. While the enzyme from Klebsiella pneumoniae is specific for L-serine, the enzyme from Clostridium perfringens can also act on L-cysteine, see EC 1.8.98.7, cysteine-type anaerobic sulfatase-maturating enzyme." +"1.8.98.7","A radical S-adenosylmethionine (AdoMet) enzyme that contains three [4Fe-4S] clusters. The enzyme, found in some bacteria, activates a type I sulfatase enzyme (EC 3.1.6.1) by converting a conserved L-cysteine residue in the active site to a unique 3-oxo-L-alanine residue that is essential for the sulfatase activity. Some enzymes can also act on L-serine, see EC 1.1.98.7, serine-type anaerobic sulfatase-maturating enzyme and EC 1.8.3.7, formylglycine-generating enzyme." +"1.11.1.25","Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [2]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Glutaredoxin-dependent peroxiredoxins have been reported from bacteria, fungi, plants, and animals. These enzymes are often able to use an alternative reductant such as thioredoxin or glutathione." +"1.11.1.26","Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. This bacterial peroxiredoxin differs from most other forms by comprising two types of subunits. One subunit (AhpC) is a typical 2-Cys peroxiredoxin. Following the reduction of the substrate, one AhpC subunit forms a disulfide bond with an identical unit. The disulfide bond is reduced by the second type of subunit (AhpF). This second subunit is a flavin-containing protein that uses electrons from NADH to reduce the cysteine residues on the AhpC subunits back to their active state." +"1.11.1.27","Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Glutathione-dependent peroxiredoxins have been reported from bacteria and animals, and appear to be 1-Cys enzymes. The mechanism for the mammalian PRDX6 enzyme involves heterodimerization of the enzyme with pi-glutathione S-transferase, followed by glutathionylation of the oxidized cysteine residue. Subsequent dissociation of the heterodimer yields glutathionylated peroxiredoxin, which is restored to the active form via spontaneous reduction by a second glutathione molecule." +"1.11.1.28","Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [2]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Two types of lipoyl-dependent peroxiredoxins have been reported from bacteria. One type is the AhpC/AhpD system, originally described from Mycobacterium tuberculosis. In that system, AhpC catalyses reduction of the substrate, resulting in an intramolecular disulfide. AhpD then forms an intermolecular disulfide crosslink with AhpC, reducing it back to active state. AhpD is reduced in turn by lipoylated proteins. The second type, which has been characterized in Xylella fastidiosa, consists of only one type of subunit, which interacts directly with lipoylated proteins." +"1.11.1.29","Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Mycoredoxin-dependent enzymes are found in Mycobacteria. Following the reduction of the substrate, the sulfenic acid derivative of the peroxidatic cysteine forms a protein mixed disulfide with the N-terminal cysteine of mycoredoxin, which is then reduced by the C-terminal cysteine of mycoredoxin, restoring the peroxiredoxin to active state and resulting in an intra-protein disulfide in mycoredoxin. The disulfide is eventually reduced by mycothiol." +"1.14.18.12","Requires iron(II). The enzyme, characterized from yeast, is involved in phytosphingosine metabolism. The reaction is mediated by iron(IV) peroxide and results in the release of a water molecule and a carbon dioxide molecule, shortening the substrate by a single carbon atom and forming an odd-numbered fatty acid. Both oxygen atoms of the original carboxylate group are released - one as the leaving water molecule, the other as one of the oxygens of the carbon dioxide molecule. The two oxygen atoms in the newly-formed carboxylate originate from the 2-hydroxy group and from molecular oxygen, respectively. The other oxygen atom of the molecular oxygen is incorporated into the leaving CO2 molecule. The enzyme from the yeast Saccharomyces cerevisiae is active at least toward C14 to C26 2-hydroxyfatty acids, but not against C8 2-hydroxyfatty acid." +"1.17.99.8","Contains FAD. The enzyme, characterized from the bacterium Castellaniella defragrans 65Phen, hydroxylates the R- and S-enantiomers at a similar rate. The in vivo electron acceptor may be a heterodimeric electron transfer flavoprotein (ETF)." +"2.7.2.17",The enzyme participates in an L-lysine biosynthetic pathway in certain species of bacteria and archaea. +"2.8.3.26","The enzyme participates in the methylaspartate cycle, an anaplerotic pathway that operates in some members of the haloarchaea and forms malate from acetyl-CoA." +"2.9.1.3",This bacterial enzyme converts 5-methylaminomethyl-2-uridine and 5-carboxymethylaminomethyl-2-uridine to the respective selenouridine forms in a two-step process that involves geranylation and subsequent phosphoselenation of the resulting geranylated intermediates. The resultant seleno-phosphorylated uridine intermediates further react with a water molecule to release a phosphate anion and 2-selenouridine tRNA. The enzyme contains a rhodanese domain. +"3.1.3.108","The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC 2.7.1.23) and NADP+ phosphatase with a slight preference for NADP+ over NADPH." +"3.2.1.211","The enzyme specifically hydrolyses (1->3)-alpha-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1->3)-linked or alternating (1->3)- and (1->4)-linked alpha-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the alpha-L-fucopyranosyl residues may occur at positions 2 and 4. The enzyme degrades fucan to sulfated alpha-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced." +"3.2.1.212","The enzyme specifically hydrolyses (1->4)-alpha-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1->3)-linked or alternating (1->3)- and (1->4)-linked alpha-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the alpha-L-fucopyranosyl residues may occur at positions 2 and 3. The enzyme degrades fucan to sulfated alpha-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced." +"3.2.1.213","The enzyme, characterized from the bacterium Bifidobacterium longum, specifically hydrolyses (1->6)-beta-galactobiose from the non-reducing terminal of (1->6)-beta-D-galactooligosaccharides with a degree of polymerization (DP) of 3 or higher, using an exo mode of action. The enzyme cannot hydrolyse alpha-L-arabinofuranosylated (1->6)-beta-galactans (as found in arabinogalactans) and does not act on (1->3)-beta-D- or (1->4)-beta-D-galactans. cf. EC 3.2.1.164, galactan endo-1,6-beta-galactosidase." +"3.6.1.73","The enzyme, characterized from the bacterium Escherichia coli, preferentially hydrolyses inosine triphosphate and xanthosine triphosphate, which are formed by oxidative deamination damage. By hydrolysing these damaged nucleotides, the enzyme prevents their incorporation into RNA." +"3.7.1.26","The enzyme, characterized from the bacterium Sphingomonas sp. SKA58, participates in an L-rhamnose degradation pathway." +"3.13.1.9","The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD+ cofactor. It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine." +"4.1.2.61",The enzyme is a member of the enoyl-CoA hydratase/isomerase superfamily. It catalyses a two-step process involving first the hydration of the double bond of feruloyl-CoA and then the cleavage of the resultant beta-hydroxy thioester by retro-aldol reaction. (E)-caffeoyl-CoA and (E)-4-coumaroyl-CoA are also substrates. +"4.2.2.27","The enzyme, isolated from the fungus Aspergillus giganteus, acts on the non-reducing end of methyl-esterified polygalacturonan, releasing either 4-deoxy--L-threo-hex-4-enopyranuronate or 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate. The enzyme is stimulated by divalent cations, with Co2+ having the strongest effect. It is able to act on substrates as short as a disaccharide, and was active on substrates with degrees of methyl esterification ranging between 34% and 90%." +"4.6.1.24","A family of related enzymes found in some fungi and bacteria. The enzyme is specific for cleavage at the 3'-phosphate group of guanosine in single stranded RNA, and catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides." +"4.6.1.25","The enzyme from bacteriophage T4 cleaves early mRNAs between Ap and Gp at one specific specific GpGpApGp site, favouring their further transition to middle-phase mRNA. The activity is enhanced by Ribosomal S1 protein. The enzyme catalyses a two-stage endonucleolytic cleavage. The first reaction produces 5'-hydroxy-phosphooligonucletides and 3'-phosphooligonucleotides ending with 2',3'-cyclic phosphodiester, which are released from the enzyme. The enzyme then hydrolyses these cyclic compounds in a second reaction that takes place only when all the susceptible 3',5'-phosphodiester bonds have been cyclised. The second reaction is a reversal of the first reaction using the hydroxyl group of water instead of the 5'-hydroxyl group of ribose. The overall process is that of a phosphorus-oxygen lyase followed by hydrolysis to form the 3'-nucleotides." +"6.2.1.62","The adenylation domain of the enzyme catalyses the activation of 3,4-dihydroxybenzoate to (3,4-dihydroxybenzoyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein domain. The aryl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.2.1.63","The adenylation domain of the enzyme catalyses the activation of L-arginine to (L-arginyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"1.1.7.1",A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3]. +"1.3.1.124","This enzyme, characterized from eukaryotic organisms, catalyses the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (3E)-3-enoyl-CoA. The best substrates for the enzyme from bovine liver have a chain-length of 8 or 10 carbons. Mammals possess both mitochondrial and peroxisomal variants of this enzyme. cf. EC 1.3.1.34, 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]." +"1.8.2.7","The enzyme, characterized from the haloalkaliphilic sulfur-oxidizing bacterium Thioalkalivibrio paradoxus, contains three copper ions in its active site. It catalyses the direct conversion of thiocyanate into cyanate and elemental sulfur without involvement of molecular oxygen." +"1.11.2.6","The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase." +"1.13.11.90",Requires Fe2+. This bacterial enzyme is involved in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate. +"1.14.11.72","Requires Fe2+ and ascorbate. The enzyme, found in bacteria, participates in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate." +"1.14.14.172","The enzyme, characterized from a number of bacterial species, participates in the degradation of 3,5,6-trichloropyridin-2-ol (TCP), a metabolite of the common organophosphorus insecticide chlorpyrifos. The enzyme is a multifunctional flavin-dependent monooxygenase that displaces three chlorine atoms by attacking three different positions in the substrate. Each reaction catalysed by the enzyme displaces a single chlorine and results in formation of a dione, which must be reduced by FADH2 before the monooxygenase could catalyse the next step. The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpX). cf. EC 1.14.14.173, 2,4,6-trichlorophenol monooxygenase." +"1.14.14.173","The enzyme, characterized from Cupriavidus pinatubonensis, participates in the degradation of 2,4,6-trichlorophenol, a compound that has been used for decades as a wood preservative. The enzyme is a multifunctional flavin-dependent monooxygenase that catalyses two different reactions to displace two chlorine atoms, a monooxygenase reaction followed by a hydrolysis reaction that takes advantage of the reactivity of the product of the first reaction, 2,6-dichloro-1,4-benzoquinone [2]. The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpB). cf. EC 1.14.14.172, 3,5,6-trichloropyridin-2-ol monooxygenase." +"1.14.19.77","The enzyme catalyses the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine. The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria." +"2.1.1.364","This entry describes enzymes that catalyse a single methylation of the L-lysine4 residue of histone H3 (H3K4), generating a monomethylated form. This modifications influence the binding of chromatin-associated proteins and result in gene activation or suppression. Some enzymes that catalyse this reaction continue to generate a dimethyated form, these enzymes are classified under EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase. Other enzymes continue to catalyse a third methylation, those are classified under EC 2.1.1.354, [histone H3]-lysine4 N-trimethyltransferase." +"2.1.1.365","Requires Mg2+. The enzyme, characterized from the bacterium Mycolicibacterium hassiacum, participates in the biosynthesis of 3-O-methylmannose polysaccharides (MMP), which are intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism in nontuberculous mycobacteria. The methylation catalysed by this enzyme was shown to block the reducing end of 3,3'-di-O-methyl-alpha-mannobiose, a probable early precursor of the 3-O-methylmannose polysaccharides." +"2.3.2.34","Some RING-type E3 ubiquitin transferases (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form complexes with a cullin scaffold protein and a substrate recognition module, which are known as CRL (Cullin-RING-Ligase) complexes. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. Like ubiquitin, the NEDD8 protein ends with two glycine residues. EC 6.2.1.64, E1 NEDD8-activating enzyme, activates NEDD8 in an ATP-dependent reaction by forming a high-energy thioester intermediate between NEDD8 and one of its cysteine residues. The activated NEDD8 is subsequently transferred to a cysteine residue of an E2 NEDD8-conjugating enzyme, and is eventually conjugated to a lysine residue of specific substrates in the presence of the appropriate E3 transferase (EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase)." +"2.3.2.35","The enzyme, found only in plants that belong to the Capsicum genus, catalyses the last step in the biosynthesis of capsaicinoids. The enzyme catalyses the acylation of vanillylamine by a branched-chain fatty acid. The exact structure of the fatty acid determines the type of capsaicinoid formed." +"2.4.1.375","The enzyme, characterized from the plant Vigna angularis (azuki beans), participates in the biosynthesis of rhamnogalacturonan I, one of the components of pectin in plant cell wall. It does not require any metal ions, and prefers substrates with a degree of polymerization larger than 9." +"2.4.1.376","The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. Glycosylation takes place at the serine in the C-X-S-X-P-C motif. The enzyme is bifunctional also being active with UDP-alpha-xylose as donor (EC 2.4.2.63, EGF-domain serine xylosyltransferase). When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein." +"2.4.2.62","The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein." +"2.4.2.63","The enzyme, found in animals and insects, xylosylates at the serine in the C-X-S-X-P-C motif of epidermal growth factor-like (EGF-like) domains. The enzyme is bifunctional also being active with UDP-alpha-glucose as donor (EC 2.4.1.376, EGF-domain serine glucosyltransferase)." +"2.4.99.22","Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-beta-D-glucosamine. The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl residues, but more slowly." +"2.6.1.119","The enzyme participates in the biosynthesis of capsaicinoids in pungent cultivars of Capsicum sp. In vivo it has only been assayed in the reverse direction, where the preferred amino group acceptors were found to be pyruvate and oxaloacetate." +"2.7.1.231","The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. Stereospecificity of the product, 3-oxoisoapionate 4-phosphate, has not been determined." +"2.7.4.33","The enzyme, characterized from the bacteria Acinetobacter johnsonii and Pseudomonas aeruginosa, transfers a phosphate group from polyphosphates to nucleotide monophosphates. The highest activity is achieved with AMP, but the enzyme can also phosphorylate GMP, dAMP, dGMP, IMP, and XMP. The reverse reactions were not detected." +"2.7.7.104","The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. The enzyme also is active as EC 5.4.2.9 phosphoenolpyruvate mutase." +"3.2.1.214","The enzyme, characterized from the bacterium Parabacteroides distasonis, specifically hydrolyses (1->2)-beta-D-glucooligosaccharides to sophorose. The best substrates are the tetra- and pentasaccharides. The enzyme is not able to cleave the trisaccharide, and activity with longer linear (1->2)-beta-D-glucans is quite low. This enzyme acts in exo mode and is not able to hydrolyse cyclic (1->2)-beta-D-glucans." +"4.1.1.120","The enzyme, characterized from several bacterial species, is involved in the degradation of D-apionate. Stereospecificity of 3-oxoisoapionate has not been determined." +"4.1.1.121","The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. It belongs to the RuBisCO-like-protein (RLP) superfamily. Stereospecificity of 3-oxoisoapionate 4-phosphate has not been determined." +"4.1.2.62","The enzyme, originally characterized from the bacterium Rhodospirillum rubrum, is involved in degradation pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are formed from S-adenosyl-L-methionine (SAM, AdoMet) by radical SAM enzymes and other types of SAM-dependent enzymes, respectively. The enzyme requires a divalent metal cation, with Co2+ producing the highest activity." +"6.2.1.64","Some RING-type E3 ubiquitin transferase (EC 2.3.2.27) are not able to bind a substrate protein directly. Instead, they form complexes with a cullin scaffold protein and a substrate recognition module, which are known as CRL (Cullin-RING-Ligase) complexes. The cullin protein needs to be activated by the ubiquitin-like protein NEDD8 in a process known as neddylation. Like ubiquitin, the NEDD8 protein ends with two glycine residues. The E1 NEDD8-activating enzyme activates NEDD8 in an ATP-dependent reaction by forming a high-energy thioester intermediate between NEDD8 and one of its cysteine residues. The activated NEDD8 is subsequently transferred to a cysteine residue of EC 2.3.2.34, E2 NEDD8-conjugating enzyme, and is eventually conjugated to a lysine residue of specific substrates in the presence of the appropriate E3 transferase (EC 2.3.2.32, cullin-RING-type E3 NEDD8 transferase)." +"6.2.2.1","Requires Mg2+. The enzyme is found in anaerobic methanogenic and methanotrophic archaea, where it modifies a glycine residue in EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase (methyl-CoM reductase). Upon binding to its substrate, an external source of sulfide attacks the target amide bond generating a tetrahedral intermediate. The amide oxyanion attacks the gamma-phosphate of ATP, releasing ADP and forming a phosphorylated thiolate intermediate that collapses to form thioglycine and phosphate. In most organisms activity requires a second protein (TfuA) , which may allosterically activate this enzyme or assist in the delivery of sulfide to the substrate." +"6.5.1.9","The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions." +"1.1.1.424","The enzyme, which participates in the degradation of D-xylose, has been characterized from several halophilic archaeal species. cf. EC 1.1.1.179, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)." +"1.3.3.16","Contains FMN. This enzyme oxidizes 2-oxazoline, 5-methyl-2-oxazoline, and 2-thiazoline within peptides, which were formed by EC 6.2.2.2, oxazoline synthase, and EC 6.2.2.3, thiazoline synthase, to the respective pyrrole-type rings. The enzyme is found as either a stand-alone protein or as a domain within a multifunctional protein (the G protein) that also functions as a peptidase." +"1.14.11.73","The enzyme, characterized from humans, catalyses the stereoselective formation of the (2S,3R)-hydroxy-L-arginine stereoisomer. So far the enzyme has been shown to act on two substrates - the 40S ribosomal protein S6 (RPS6), which is hydroxylated at R137, and, at a lower activity, RCCD1, a protein involved in chromatin stability, which is hydroxylated at R141. Even though the same stereoisomer is produced by the bacterial EC 1.14.11.47, [50S ribosomal protein L16]-arginine 3-hydroxylase, the two enzymes do not exhibit any cross-reactivity on their respective ribosomal protein substrates." +"1.14.11.74",Requires Fe2+ and ascorbate. The enzyme has been characterized from the bacterium Pantoea ananatis. +"1.14.11.75",Requires Fe2+ and ascorbate. The enzyme has been characterized from the bacterium Pantoea ananatis. +"1.14.14.174","A cytochrome P-450 (heme-thiolate) protein found in plants, where it is part of the biosynthesis pathway of the red naphthoquinone pigment shikonin." +"1.14.14.175","A cytochrome P-450 (heme thiolate) enzyme found in some members of the Lamiaceae (mint family). The enzyme from Rosmarinus officinalis (rosemary) is involved in biosynthesis of carnosic acid, while the enzyme from the Chinese medicinal herb Salvia miltiorrhiza is involved in the biosynthesis of the tanshinones, abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components found in the plant." +"1.14.14.176","This microsomal cytochrome-P-450 (heme-thiolate) enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation." +"1.17.9.2","Contains FAD. This enzyme, characterized from the bacterium Pseudomonas sp. SG-MS2, catalyses the incorporation of an oxygen atom originating from a water molecule into position C-6 of the lignan (+)-pinoresinol. The enzyme consists of a flavoprotein subunit and a c-type cytochrome subunit. Electrons that originate in the substrate are transferred via the FAD cofactor and the cytochrome subunit to the blue-copper protein azurin." +"2.1.1.366","The enzyme methylates only dimethylated lysine9 of histone H3 (H3K9), forming the trimethylated form. This modification influences the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. The enzyme is highly upregulated in Huntington disease patients. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, and EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase." +"2.1.1.367","This entry describes several enzymes that methylate the L-lysine-9 residue of histone H3 (H3K9) only once, generating a monomethylated form. These modifications influence the binding of chromatin-associated proteins. cf. EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase, and EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase." +"2.1.1.368","This entry describes several enzymes, characterized from plants, that successively methylate the L-lysine-9 residue of histone H3 (H3K9) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase." +"2.1.1.369","This entry describes enzymes that methylate the L-lysine-27 residue of histone H3 only once, generating a monomethylated form. This modification influences the binding of chromatin-associated proteins. The methylation of lysine-27 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.371, [histone H3]-lysine27 N-dimethyltransferase, and EC 2.1.1.356, [histone H3]-lysine27 N-trimethyltransferase." +"2.1.1.370","This entry describes enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. The human NSD3 protein also catalyses the activity of EC 2.1.1.hq, [histone H3]-lysine27 N-dimethyltransferase. cf. EC 2.1.1.364, [histone H3]-lysine4 N-methyltransferase, and EC 2.1.1.354, [histone H3]-lysine4 N-trimethyltransferase." +"2.1.1.371","This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. The human NSD3 protein also catalyses the activity of EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase. cf. EC 2.1.1.369, [histone H3]-lysine27 N-methyltransferase, and EC 2.1.1.356, [histone H3]-lysine27 N-trimethyltransferase." +"2.1.1.372","The enzyme, characterized from the fission yeast Schizosaccharomyces pombe, catalyses three successive methylations of the L-lysine-20 residue of histone H4 (H4K20), forming the trimethylated form. The methylation of this site is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response. cf. EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase, and EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase." +"2.7.7.105","This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor, in mycobacteria. cf. EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase and EC 2.7.7.106, 3-phospho-(R)-glycerate guanylyltransferase." +"2.7.7.106","The enzyme, characterized from the Gram-negative bacterium Paraburkholderia rhizoxinica, participates in the biosynthesis of 3PG-factor 420. The enzyme can also accept 2-phospho-L-lactate and phosphoenolpyruvate, but activity is much higher with 3-phospho-D-glycerate. cf. EC 2.7.7.68, 2-phospho-L-lactate guanylyltransferase and EC 2.7.7.105, phosphoenolpyruvate guanylyltransferase." +"6.2.1.65","The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A." +"6.2.2.2","Requires Mg2+. The enzyme, which participates in the biosynthesis of ribosomal peptide natural products (RiPPs), converts L-cysteine, L-serine and L-threonine residues to thiazoline, oxazoline, and methyloxazoline rings, respectively. The enzyme requires two domains - a cyclodehydratase domain, known as a YcaO domain, and a substrate recognition domain (RRE domain) that controls the regiospecificity of the enzyme. The RRE domain can either be fused to the YcaO domain or occur as a separate protein; however both domains are required for activity. The enzyme can process multiple residues within the same substrate peptide, and all enzymes characterized so far follow a defined order, starting with the L-cysteine closest to the C-terminus. The reaction involves phosphorylation of the preceding ribosomal peptide backbone amide bond, forming ADP and a phosphorylated intermediate, followed by release of the phosphate group. In some cases the enzyme catalyses a side reaction in which the phosphorylated intermediate reacts with ADP to form AMP and diphosphate." +"6.2.2.3","Requires Mg2+. The enzyme, which participates in the biosynthesis of some ribosomal peptide natural products (RiPPs) such as the trunkamides, converts L-cysteine residues to thiazoline rings. The enzyme requires two domains - a cyclodehydratase domain, known as a YcaO domain, and a substrate recognition domain (RRE domain) that controls the regiospecificity of the enzyme. The RRE domain can either be fused to the YcaO domain or occur as a separate protein; however both domains are required for activity. The enzyme can process multiple L-cysteine residues within the same substrate peptide, and all enzymes characterized so far follow a defined order, starting with the L-cysteine closest to the C-terminus. The reaction involves phosphorylation of the preceding ribosomal peptide backbone amide bond, forming ADP and a phosphorylated intermediate, followed by release of the phosphate group. In some cases the enzyme catalyses a side reaction in which the phosphorylated intermediate reacts with ADP to form AMP and diphosphate. This activity is also catalysed by the related enzyme EC 6.2.2.2, oxazoline synthase. That enzyme differs by having an RRE domain that also recognizes L-serine and L-threonine residues, which are converted to oxazoline and methyloxazoline rings, respectively." +"1.2.1.104","The pyruvate dehydrogenase system (PDH) is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.4.1.27, glycine cleavage system, and EC 2.3.1.190, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3). The reaction catalysed by this system is the sum of three activities: EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) (E1), EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase (E2), and EC 1.8.1.4, dihydrolipoyl dehydrogenase (E3). The mammalian system also includes E3 binding protein, which is involved in the interaction between the E2 and E3 subunits." +"1.2.1.105","The 2-oxoglutarate dehydrogenase system is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, EC 1.2.1.104, pyruvate dehydrogenase system, EC 1.4.1.27, glycine cleavage system, and EC 2.3.1.190, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3). This enzyme system converts 2-oxoglutarate to succinyl-CoA and produces NADH and CO2 in a complicated series of irreversible reactions. The reaction catalysed by this system is the sum of three activities: EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) (E1), EC 2.3.1.61, dihydrolipoyllysine-residue succinyltransferase (E2) and EC 1.8.1.4, dihydrolipoyl dehydrogenase (E3)." +"1.3.8.16","The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]." +"1.4.1.27","The glycine cleavage (GCV) system is a large multienzyme complex that belongs to the 2-oxoacid dehydrogenase complex family, which also includes EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.2.1.104, pyruvate dehydrogenase system, and EC 2.3.1.190, acetoin dehydrogenase system. The GCV system catalyses the reversible oxidation of glycine, yielding carbon dioxide, ammonia, 5,10-methylenetetrahydrofolate and a reduced pyridine nucleotide. Tetrahydrofolate serves as a recipient for one-carbon units generated during glycine cleavage to form the methylene group. The GCV system consists of four protein components, the P protein (EC 1.4.4.2, glycine dehydrogenase (aminomethyl-transferring)), T protein (EC 2.1.2.10, aminomethyltransferase), L protein (EC 1.8.1.4, dihydrolipoyl dehydrogenase), and the non-enzyme H protein (lipoyl-carrier protein). The P protein catalyses the pyridoxal phosphate-dependent liberation of CO2 from glycine, leaving a methylamine moiety. The methylamine moiety is transferred to the lipoic acid group of the H protein, which is bound to the P protein prior to decarboxylation of glycine. The T protein catalyses the release of ammonia from the methylamine group and transfers the remaining C1 unit to tetrahydrofolate, forming 5,10-methylenetetrahydrofolate. The L protein then oxidizes the lipoic acid component of the H protein and transfers the electrons to NAD+, forming NADH." +"1.4.3.26","A flavoprotein (FMN). The enzyme participates in the biosynthesis of the enzyme cofactor mycofactocin. The enzyme uses oxygen as an electron source to oxidize a C-N bond, followed by spontaneous exchange with water to form an alpha-keto moiety on the resulting molecule." +"1.13.11.91","This bacterial enzyme contains an iron(2+) atom coordinated by three protein-derived histidines and a Ser-His-Tyr motif. It is similar to EC 1.13.11.20, cysteine dioxygenase, and can act on L-cysteine, but has a much higher activity with its native substrate, 3-sulfanylpropanoate." +"1.14.11.76","Requires Fe2+ and L-ascorbate. The enzyme, characterized from the basidiomycete mushroom Amanita muscaria, participates in the biosynthesis of the psychoactive compounds ibotenate and muscimol." +"1.14.15.38","The enzyme, found in members of the Sphingobium genus, initiates the degradation of N,N-dimethyl-phenylurea herbicides by mono-N-demethylation. The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyses the monooxygenation of a methyl group. The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde. The enzyme associates with additional proteins (a reductase and a [3Fe-4S] type ferredoxin) that are involved in the transfer of electrons from NAD(P)H to the active site." +"1.14.99.67","The enzyme, isolated from the bacterium Streptomyces venezuelae, is involved in the biosynthesis of the antibiotic chloramphenicol. It contains a carboxylate-bridged binuclear non-heme iron cluster. The components of the native electron chain have not been identified, although the immediate donor is likely to be an iron-sulfur protein. The reaction mechanism involves formation of an extremely stable peroxo intermediate that catalyses three individual two-electron oxidations via a hydroxylamine and a nitroso intermediates without releasing the intermediates. cf. EC 1.14.99.68, 4-aminobenzoate N-oxygenase." +"1.14.99.68","The enzyme, characterized from the bacterium Streptomyces thioluteus, catalyses an early step in the biosynthesis of the antibiotic aureothin. It contains a carboxylate-bridged binuclear non-heme iron cluster. The native electron donor has not been identified, but is likely an iron-sulfur protein. The reaction mechanism involves formation of an extremely stable peroxo intermediate that catalyses three two-electron oxidations via a hydroxylamine and dihydroxylamine intermediates. cf. EC 1.14.99.67, N-[1-(4-aminophenyl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide N-oxygenase." +"1.14.99.69","The enzyme, found only within a small subset of facultative anaerobic bacteria, belongs to the nonheme diiron family. The enzyme from Salmonella typhimurium was shown to catalyse a stereoselective (E)-hydroxylation at the terminal C4-position of the prenyl group." +"1.17.98.4","Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1]." +"1.17.99.9","Contains a heme b cofactor. The enzyme catalyses the conversion of heme o to heme a by two successive hydroxylations of the methyl group at C-8, using water as the oxygen source. The first hydroxylation forms heme i, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme a [2,4]. The electrons produced by the reaction are transferred to a heme b cofactor [6]. However, the electron acceptor that is used to restore the heme b cofactor to its oxidized state is still not known (both a thioredoxin-like protein and menaquinol have been proposed)." +"1.17.99.10","The enzyme, characterized from the bacterium Sterolibacterium denitrificans, participates in the anaerobic degradation of cholesterol. The enzyme can accept several substrates including vitamin D3. The enzyme contains a bis(guanylyl molybdopterin) cofactor, five [Fe-S] clusters, and one heme b. cf. EC 1.14.99.38, cholesterol 25-monooxygenase, an oxygen-requiring eukaryotic enzyme that catalyses a similar transformation." +"1.17.99.11","A molybdenum enzyme. The enzyme, characterized from the bacterium Steroidobacter denitrificans, is involved in the anaetrobic degradation of steroids. It is specific to 3-oxo-Delta1-steroids such as androsta-1-ene-3,17-dione and Delta1-dihydrotestosterone and does not act on 3-oxo-Delta4-steroids." +"2.1.1.373","The enzyme, characterized from the marine bacterium Labrenzia aggregata, participates in the biosynthesis of dimethylsulfoniopropanoate (DMSP). A eukaryotic enzyme that shares little sequence similarity with the bacterial enzyme was identified in many marine phytoplankton species." +"2.1.1.374","The enzyme, found in mycobacteria, is a member of a family of heterocyclic toxin methyltransferases. It is involved in defense against several antimicrobial natural compounds and drugs. 4-Hydroxyquinolin-2(1H)-one, 2-heptylquinolin-4(1H)-one, 2-heptyl-3-hydroxyquinolin-4(1H)-one (the ""Pseudomonas quinolone signal"", PQS) and the flavonol quercetin are also O-methylated, albeit with lower activity [2]. The enzyme also N-methylates the bactericidal compound 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile [1]. " +"2.2.1.13","The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose." +"2.3.2.36","This relatively rare subpopulation of RING-type E3 ubiquitin transferases (cf. EC 2.3.2.27), found in mammals and herpes viruses, can transfer ubiquitin to a cysteine residue in target proteins. Additional ubiquitin molecules are polymerized on top of the initial ubiquitin molecule by formation of an isopeptide linkage with lysine48 in the pre-attached ubiquitin [2]." +"2.5.1.153","The enzyme, characterized from the bacterial pathogen Mycobacterium tuberculosis, produces 1-tuberculosinyladenosine, an unusual terpene nucleoside that acts as a phagolysosome disruptor by neutralizing the pH, resulting in swelling of the lysosome and obliteration of its multilamellar structure." +"3.1.1.115","The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose." +"3.5.1.136","The enzyme, characterized from the archaeons Thermococcus kodakarensis and Pyrococcus horikoshii, deacetylates the non-reducing residue of N,N'-diacetylchitobiose, the end product of the archaeal chitinase, to produce beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine. This is in contrast to EC 3.5.1.105, chitin disaccharide deacetylase, which deacetylates N,N'-diacetylchitobiose at the reducing residue to produce N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine." +"3.7.1.27","The enzyme, characterized from Glycine max (soybeans), is specific for neryl diphosphate." +"5.1.3.44","The enzyme, characterized from multiple bacterial species, catalyses the interconversion between beta-D-glucopyranose and beta-D-mannopyranose through proton abstraction-addition at the C2 position." +"5.3.1.36","The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose." +"1.1.1.425","Levoglucosan is formed from the pyrolysis of carbohydrates such as starch and cellulose and is an important molecular marker for pollution from biomass burning. This enzyme is present only in bacteria, and has been characterized from Arthrobacter sp. I-552 and Pseudarthrobacter phenanthrenivorans. cf. EC 2.7.1.232, levoglucosan kinase." +"1.2.1.106","The enzyme participates in an L-arginine biosynthesis pathway in certain species of archaea and bacteria. In some organisms the enzyme is bifunctional and also catalyses the activity of EC 1.2.1.103, [amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase." +"1.3.8.17","This enzyme is involved in the biosynthesis of factor 420 (coenzyme F420), a redox-active compound found in all methanogenic archaea, as well as some eubacteria. In some eubacteria the enzyme is multifunctional, also catalysing the activities of EC 6.3.2.31, coenzyme F420-0:L-glutamate ligase, and EC 6.3.2.34, coenzyme F420-1:gamma-L-glutamate ligase." +"1.3.98.7","This is a bifunctional radical AdoMet (radical SAM) enzyme that catalyses the first two steps in the biosynthesis of the enzyme cofactor mycofactocin. Activity requires the presence of the MftB chaperone. The other activity of the enzyme is EC 4.1.99.26, 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase." +"1.5.1.54","A flavoprotein (FAD). The enzyme, found in plants and some bacteria, catalyses the reversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADH as the electron donor. It play an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. These proteins either contain a C-terminal domain that does not mediate allosteric regulation (as in plants) or lack this domain entirely (as in Escherichia coli). As a result, the plant enzymes are not inhibited by S-adenosyl-L-methionine, unlike other eukaryotic enzymes, and catalyse a reversible reaction. cf. EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin)." +"1.14.14.177","The enzyme, which is expressed in the epidermis of mammals, catalyses the omega-hydroxylation of ultra-long-chain fatty acids (C28 to C36). The products are incorporated into acylceramides, epidermis-specific ceramide species that are very important for skin barrier formation." +"1.14.15.39","This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone." +"1.14.19.78","The enzyme, characterized from the bacterium Teredinibacter turnerae, is specific for decanoyl-[acyl-carrier protein]. Activity is maximal when decanoate is loaded onto a dedicated acyl-carrier protein (TtuC), which is encoded by a gene in the same operon." +"2.1.1.375","The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses) catalyses two successive methylations. In higher eukaryotes the two methylations occur in the reverse order and are catalysed by two different enzymes (cf. EC 2.1.1.56, mRNA (guanine-N7)-methyltransferase, and EC 2.1.1.57, methyltransferase cap1) that do not required a specific motif." +"2.2.1.14","The enzyme, characterized from the bacterium Bacillus aryabhattai SOS1, is involved in a degradation pathway for 6-sulfo-D-quinovose. The enzyme can also use D-erythrose 4-phosphate as the acceptor, forming D-sedoheptulose 7-phosphate." +"2.3.1.301","The enzyme, characterized from mycobacteria, provides a link between the type I and type II fatty acid synthase systems (FAS-I and FAS-II, respectively) found in these organisms. The enzyme acts on medium- and long-chain acyl-CoAs (C12-C16) produced by the FAS-I system, condensing them with malonyl-[acyl-carrier protein] (malonyl-AcpM) and forming starter molecules for the FAS-II system, which elongates them into meromycolic acids. The enzyme has no activity with short-chain acyl-CoAs (e.g. acetyl-CoA), which are used by EC 2.3.1.180, beta-ketoacyl-[acyl-carrier-protein] synthase III, or branched-chain acyl-CoAs, which are used by EC 2.3.1.300, branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase." +"2.3.1.302","The enzyme participates in the biosynthesis of avenanthramides, phenolic alkaloids found mainly in oats (Avena sativa). It is related to EC 2.3.1.133, shikimate O-hydroxycinnamoyltransferase. The enzyme from oat does not accept feruloyl-CoA as a substrate." +"2.3.1.303","The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains." +"2.4.1.377","The enzyme, characterized from several Salmonella strains, participates in the biosynthesis of the repeat unit of O antigens produced by strains that belong to the A, B, D and E groups." +"2.4.1.378","The enzyme from Salmonella participates in the biosynthesis of the repeat unit of O antigens produced by strains that belong to the A, B, and D1 groups." +"2.4.1.379","The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains." +"2.4.1.380","The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains." +"2.4.1.381","The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains." +"2.4.1.382","The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains." +"2.4.1.383",The enzyme participates in the biosynthesis of the O antigens produced by group E and D2 strains of the pathogenic bacterium Salmonella enterica. +"2.7.1.232","Levoglucosan is formed from the pyrolysis of carbohydrates such as starch and cellulose and is an important molecular marker for pollution from biomass burning. The enzyme, found in yeast and fungi, requires a magnesium ion. cf. EC 1.1.1.425, levoglucosan dehydrogenase." +"2.7.4.34","Polyphosphate kinase 2, characterized from the bacterium Pseudomonas aeruginosa, uses inorganic polyphosphate as a donor to convert GDP to GTP. The enzyme can also act on ADP (cf. EC 2.7.4.1, ATP-polyphosphate phosphotransferase), but with lower activity. The enzyme has only a trivial activity in the opposite direction (synthesizing polyphosphate from GTP). The GTP that is produced is believed to be consumed by EC 2.7.7.13, mannose-1-phosphate guanylyltransferase, for production of alginate during stationary phase." +"3.1.1.116","The enzyme, present in animals, is specific for the sn-1 position. When acting on 1-acyl-2-arachidonoyl-sn-glycerol, the enzyme forms 2-arachidonoylglycerol, the most abundant endocannabinoid in the mammalian brain." +"3.1.1.117",The enzyme occurs in microorganisms and catalyses the cleavage of the ester bonds between glucuronoyl or 4-O-methyl-glucuronoyl groups attached to xylan and aliphatic or aromatic alcohols in lignin polymers. +"3.1.4.61","The enzyme degrades cyclic 2,3-bisphosphoglycerate, a thermoprotectant that is produced by certain archaeal genera. Two different enzymes that catalyse this activity, one soluble and one membrane-bound, have been characterized from the archaeon Methanothermobacter thermautotrophicus." +"3.6.1.74","The enzyme, found in eukaryotes and some plus strand RNA viruses (e.g. alphavirus), is involved in mRNA capping. Unlike the eukaryotic enzyme, the viral enzyme requires a purine in the first position of the mRNA. The human enzyme is a multi domain protein that also has the activity of EC 2.7.7.50, mRNA guanylyltransferase." +"4.1.99.26","This is a bifunctional radical AdoMet (radical SAM) enzyme that catalyses the first two steps in the biosynthesis of the enzyme cofactor mycofactocin. Activity requires the presence of the MftB chaperone. The reaction occurs in the right-to-left direction. The other activity of the enzyme is EC 1.3.98.7, [mycofactocin precursor peptide]-tyrosine decarboxylase." +"5.3.3.23","The enzyme, characterized from the bacterium Rhodospirillum rubrum, participates in methionine salvage from S-methyl-5'-thioadenosine. It is a RuBisCO-like protein (RLP) that is not capable of carbon fixation, and catalyses an isomerization reaction that converts S-methyl-5-thio-D-ribulose 1-phosphate to a 3:1 mixture of S-methyl-1-thioxylulose 5-phosphate and S-methyl-1-thioribulose 5-phosphate. The reaction is an overall 1,3-proton transfer, which likely consists of two 1,2-proton transfer events." +"6.2.1.66","The adenylation domain of the enzyme catalyses the activation of glycine to (glycyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein (as in the case of DhbF in bacillibactin biosynthesis), or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.2.1.67","The adenylation domain of the enzyme catalyses the activation of L-alanine to (L-alanyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.2.1.68","The adenylation domain of the enzyme catalyses the activation of L-glutamate to (L-glutamyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.3.1.21","Two enzymes are known to catalyse the third step in de novo purine biosynthesis. This enzyme requires ATP and utilizes formate, which is provided by the hydrolysis of 10-formyltetrahydrofolate by EC 3.5.1.10, formyltetrahydrofolate deformylase. The other enzyme, EC 2.1.2.2, phosphoribosylglycinamide formyltransferase 1, utilizes 10-formyltetrahydrofolate directly. Formyl phosphate is formed during catalysis as an intermediate. The enzyme from the bacterium Escherichia coli can also catalyse the activity of EC 2.7.2.1, acetate kinase." +"6.3.2.59","The enzyme participates in the biosynthesis of L-pyrrolysine, a naturally occurring, genetically coded amino acid found in some methanogenic archaea and a few bacterial species. L-pyrrolysine is present in several methyltransferases that are involved in methyl transfer from methylated amine compounds to coenzyme M." +"6.3.2.60","The enzyme, originally characterized from the archaeon Sulfolobus acidocaldarius, is involved in L-arginine biosynthesis. The enzyme from the archaeon Thermococcus kodakarensis is bifunctional and also catalyses the activity of EC 6.3.2.43, [amino-group carrier protein]---L-2-aminoadipate ligase." +"7.1.1.10","The enzyme, present in plants and cyanobacteria, couples electron transport from ferredoxin to plastoquinone and proton pumping from the cytoplasm to the thylakoid lumen. It participates in cyclic electron flow, retuning electrons generated by photosystem I to the plastoquinone pool, thus bypassing the generation of reducing power. It may also participate in respiration using electrons originating from NADPH via the action of EC 1.18.1.2, ferredoxin---NADP+ reductase (FNR) operating in the direction of ferredoxin reduction. It is a large complex, with some of its subunits resembling those from the bacterial/mitochondrial EC 7.1.1.2, NADH:ubiquinone reductase (H+-translocating). However, it lacks the NADH-oxidizing module and instead has a module that interacts with ferredoxin. Several forms of the enzyme exist, differing in their exact combination of subunits used. Some of the forms participate in carbon dioxide hydration rather than electron transfer." +"7.2.2.22","A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, detected in mycobacteria, is a high affinity slow turnover ATPase exporting Mn2+." +"7.4.2.14","An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. This entry describes vertebrate transporters involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with major histocompatibility complex (MHC) class I molecules. The substrates are generated mainly from degradation of cytosolic proteins by the proteasome." +"1.1.1.426","The enzyme participates in the biosynthesis of N-acetyl-alpha-D-quinovosamine, a 6-deoxy sugar that is present in the O antigens of many Gram-negative bacteria, including Pseudomonas aeruginosa serotypes O6 and O10, Rhizobium etli, and Brucella abortus." +"1.1.5.14","The enzyme, characterized from the bacterium Gluconobacter japonicus, is a heterotrimer composed of an FAD-containing large subunit, a small subunit, and a heme c-containing subunit, which is responsible for anchoring the complex to the cytoplasmic membrane and for transferring the electrons to ubiquinone." +"1.2.1.107","The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arsono-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system." +"1.13.11.92","Contains heme. This plant enzyme catalyses the (2R)-hydroperoxidation of fatty acids. It differs from lipoxygenases and cyclooxygenases in that the oxygen addition does not target an unsaturated region in the fatty acid. In vitro the product undergoes spontaneous decarboxylation, resulting in formation of a chain-shortened aldehyde. In vivo the product may be reduced to a (2R)-2-hydroxyfatty acid. The enzyme, which is involved in responses to different abiotic and biotic stresses, has a wide substrate range that includes both saturated and unsaturated fatty acids." +"1.14.11.77","Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. The type II sulfatases oxidize the C-H bond of the carbon next to the sulfate ester, using 2-oxoglutarate and oxygen as substrates. The resulting hemiacetal sulfate ester collapses, liberating inorganic sulfate and an alkyl aldehyde along with carbon dioxide and succinate. The enzymes often desulfate a broad spectrum of linear and branched-chain sulfate esters. The enzyme from Pseudomonas putida acts on a range of medium-chain alkyl sulfate esters, with chain lengths ranging from C(4) to C(12). cf. sulfatase EC 3.1.6.1, arylsulfatase (type I), EC 3.1.6.21, linear primary-alkylsulfatase, and EC 3.1.6.22, branched primary-alkylsulfatase." +"1.16.99.1","Methyltrophic corrinoid proteins must have the cobalt atom in the active cobalt(I) state to become methylated. Because the cobalt(I)/cobalt(II) transformation has a very low redox potential the corrinoid cofactor is subject to adventitious oxidation to the cobalt(II) state, which renders the proteins inactive. This enzyme, characterized from the methanogenic archaeon Methanosarcina barkeri, reduces cobalt(II) back to cobalt(I), restoring activity. The enzyme acts on the corrinoid proteins involved in methanogenesis from methylamine, dimethylamine, and trimethylamine, namely MtmC, MtbC, and MttC, respectively. While in vitro the enzyme can use Ti(III)-citrate as the electron donor, the in vivo donor is not known. The enzyme from Methanosarcina barkeri contains a C-terminal [4Fe-4S] ferredoxin-like domain." +"2.1.1.376","The enzyme, which catalyses the transfer of a methyl group from glycine betaine to a glycine betaine-specific corrinoid protein (MtgC), is involved in methanogenesis from glycine betaine in some methanogenic archaea, and in glycine betaine degradation in some bacteria. Unlike similar enzymes involved in methanogenesis from methylated C1 compounds, this enzyme does not contain the unusual amino acid L-pyrrolysine." +"2.1.1.377","The enzyme, which is involved in methanogenesis from glycine betaine, catalyses the transfer of a methyl group bound to the cobalt cofactor of glycine betaine-specific corrinoid protein to coenzyme M, forming the substrate for EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase, which catalyses the final step in methanogenesis. The enzyme from the methanogenic archaeon Methanolobus vulcani B1d can also catalyse the activity of EC 2.1.1.246, [methyl-Co(III) methanol-specific corrinoid protein]---coenzyme M methyltransferase." +"2.1.1.378","This enzyme, characterized from the anaerobic bacterium Desulfitobacterium hafniense Y51, catalyses a similar reaction to that of EC 2.1.1.258, 5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase, but in the opposite direction, transferring a methyl group from a methylated corrinoid protein to tetrahydrofolate. The corrinoid protein is specifically methylated by EC 2.1.1.376, glycine betaine---corrinoid protein Co-methyltransferase." +"2.1.1.379","The enzyme, present in methanogenic archaea, catalyses a modification of an L-arginine residue at the active site of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase (better known as methyl-coenzyme M reductase), which catalyses the last and methane-releasing step of methanogenesis. The enzyme is a radical AdoMet (radical SAM) enzyme and contains a [4Fe-4S] cluster and a Coalpha-[alpha-(5-hydroxybenzimidazolyl)]-cobamide cofactor. The methyl group, which is derived from S-adenosyl-L-methionine, is transferred to the cob(I)amide cofactor, forming methylcob(III)amide as an intermediate carrier, before being transferred to the arginine residue." +"2.1.2.14","The enzyme, characterized from the bacterium Brucella melitensis, synthesizes a building block of the O antigen produced by Brucella species." +"2.4.1.384","The enzyme, characterized from the bacterium Bacillus licheniformis DSM-13, is an extremely promiscuous glycosyltransferase. It can accept ADP-, GDP-, CDP-, TDP-, or UDP-activated glycose molecules as donors, and can glycosylate a large number of substrates, catalysing O-, N-, or S-glycosylation. While D-glucose is the primarily reported sugar being transferred, the enzyme has been shown to transfer D-galactose, 2-deoxy-D-glucose, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, L-fucose, L-rhamnose, D-glucuronate, and D-viosamine." +"2.7.1.233","The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose." +"2.7.2.18","The enzyme is a dimeric complex consisting of an ATP-binding protein (FakA) and a fatty acid-binding protein (FakB). The first step in the reaction is the binding of FakB (with a bound fatty acid) to FakA. The fatty acid bound to FakB is then phosphorylated by FakA, and the fatty acyl phosphate-bound FakB is released from the complex. In the presence of an exchangeable fatty acid pool in the cell membrane, the fatty acy phosphate bound to FakB exchanges with a fatty acid to regenerate the substrate for FakA. The system is widespread in Gram-positive bacteria, with most strains possessing a single FakA protein along with multiple FakB subunits that differ in their specificity towards fatty acid substrates." +"2.8.2.40",The enzyme catalyses the last step in the production of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex. +"3.1.1.118","The human enzyme shows broad specificity, and has a preference for phosphatidate over other phospholipids. Unlike EC 3.1.1.32, phospholipase A1, it is also active against phosphatidylinositol. It is not active towards acyl groups linked at the sn-2 position." +"3.1.6.21","Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III sulfatase family. It is active against linear primary-alkyl sulfate esters, such as dodecyl sulfate, decyl sulfate, octyl sulfate, and hexyl sulfate. The enzyme from Pseudomonas aeruginosa is secreted out of the cell. The catalytic mechanism begins with activation of a water molecule by the binuclear Zn2+ cluster, resulting in a nucleophilic attack on the carbon atom. cf. EC 3.1.6.22, branched primary-alkylsulfatase, and EC 3.1.6.19, (R)-specific secondary-alkylsulfatase (type III)." +"3.1.6.22","Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III family. The enzyme, characterized from a Pseudomonas strain, is specific for branched primary-alkyl sulfate esters and does not act on linear substrates such as dodecyl sulfate. cf. EC 3.1.6.1, arylsulfatase (type I), EC 1.14.11.77, alkyl sulfatase, EC 3.1.6.19, (R)-specific secondary-alkylsulfatase (type III) and EC 3.1.6.21, linear primary-alkylsulfatase." +"3.1.21.10",The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded DNA molecules that do not contain Holliday junctions. +"3.4.14.14","Requires Fe2+ ad Zn2+. The enzyme participates in the biosynthesis of the enzyme cofactor mycofactocin. It catalyses cleavage of the mycofactocin precursor peptide following its modification by MftC to liberate its final two residues, which consist of a cross-linked valine-tyramine dipeptide." +"3.7.1.28","The enzyme, which belongs to the RuBisCO-like-protein (RLP) superfamily, has been characterized from several bacterial species. It participates in the degradation of D-apionate. The reaction is initiated by decarboxylation to generate a stabilized enediolate intermediate, with the sequestered CO2 carboxylating the adjacent enediolate carbon atom. The resulting 3-ketose-1-phosphate intermediate is hydrolysed, as in the authentic RuBisCO-catalysed reaction, to generate glycolate and 3-phospho-D-glycerate. Stereospecificity of 3-oxoisoapionate 4-phosphate has not been determined." +"4.1.2.63","Requires Mg2+ and thiamine diphosphate. This peroxisomal enzyme, found in animals, is involved in the alpha-oxidation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids." +"4.2.1.176","The enzyme, characterized from several bacterial species, is involved in an L-lyxonate degradation pathway." +"4.2.1.177","The enzyme, characterized from the bacterium Klebsiella oxytoca, participates in (2S)-2,3-dihydroxypropane-1-sulfonate degradation. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster." +"4.4.1.38","The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, participates in a taurine degradation pathway that leads to sulfide production. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster." +"4.4.1.39","The enzyme, characterized from the cyanobacterium Microchaete diplosiphon, catalyses the attachment of the phycobilin chromophore (3E)-phycoerythrobilin (PEB) to cysteine 82 of the alpha subunit of the phycobiliprotein C-phycoerythrin. The numbering used here corresponds to the enzyme from Microchaete diplosiphon, and could vary slightly in other organisms. Activity is greatly enhanced in the presence of the chaperone-like protein CpeZ. The reaction could also be catalysed by EC 4.4.1.29, phycobiliprotein cysteine-84 phycobilin lyase, but much less efficiently." +"4.4.1.40","The enzyme, characterized from the cyanobacterium Microchaete diplosiphon, catalyses the attachment of the phycobilin chromophore (3E)-phycoerythrobilin (PEB) to cysteine 48 and 59 of the beta subunits of the phycobiliprotein C-phycoerythrin. The enzyme first ligates the A ring of PEB to cysteine-48, followed by the attachment of the D ring to cysteine-59. The numbering used here corresponds to the enzyme from Microchaete diplosiphon, and could vary slightly in other organisms. The reaction requires the presence of the chaperone-like protein CpeZ." +"4.4.1.41","The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster." +"6.2.1.69","The adenylation domain of the enzyme catalyses the activation of L-cysteine to (L-cysteinyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.2.1.70","The adenylation domain of the enzyme catalyses the activation of L-threonine to (L-threonyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein (as in the case of DhbF in bacillibactin biosynthesis), or of a different protein (as in the case of PmsD in pseudomonine biosynthesis). This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.2.1.71","The adenylation domain of the enzyme catalyses the activation of 2,3-dihydroxybenzoate to (2,3-dihydroxybenzoyl)adenylate, followed by the transfer the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein domain of a specific non-ribosomal peptide synthase. For example, the EntE enzyme of Escherichia coli is part of the enterobactin synthase complex, the VibE enzyme of Vibrio cholerae is part of the vibriobactin synthase complex, and the DhbE enzyme of Bacillus subtilis is part of the bacillibactin synthase complex." +"6.2.1.72","The adenylation domain of the enzyme catalyses the activation of L-serine to (L-seryl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.2.1.73","The adenylation domain of the enzyme catalyses the activation of L-tryptophan to (L-tryptophyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.2.1.74","During the biosynthesis of most ansamycin antibiotics such as rifamycins, streptovaricins, naphthomycins, and chaxamycins, the activity is catalysed by the loading domain of the respective polyketide synthase (PKS), which transfers the substrate to the acyl-carrier protein domain of the first extension module of the PKS. During the biosynthesis of the mitomycins the reaction is catalysed by the MitE protein, which transfers the substrate to a dedicated acyl-carrier protein (MmcB)." +"6.3.4.25","The enzyme, characterized from a number of bacteriophages, participates in the biosynthesis of dZTP, which replaces dATP in the genome of these phages." +"7.1.1.11","This iron-sulfur and flavin-containing electron transport complex, isolated from some anaerobic bacteria, couples the energy from reduction of NAD+ by ferredoxin to pumping protons out of the cell, generating a proton motive force across the cytoplasmic membrane. Most similar complexes pump sodium ions rather than protons [cf. EC 7.2.1.2, ferredoxin---NAD+ oxidoreductase (Na+-transporting)]." +"7.1.3.2","Requires Na+ and K+. This enzyme, found in some bacteria and archaea, couples the energy from diphosphate hydrolysis to active sodium translocation across the membrane. The enzyme is electrogenic, as the Na+ transport results in generation of a positive potential in the inner side of the membrane." +"1.7.2.9","The enzyme, characterized from the anaerobic ammonium-oxidizing (anammox) bacterium Kuenenia stuttgartiensis, is very similar to EC 1.7.2.6, hydroxylamine dehydrogenase. Both enzymes are homotrimeric enzymes in which each subunit contains seven c-type hemes and one specialized P460-type heme that is bound to a tyrosine residue in an adjacent subunit. However, this enzyme catalyses only the 3 electron oxidation of hydroxylamine, forming nitric oxide, and is not capable of performing further oxidation to form nitrite." +"1.14.13.248","The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites. Requires an FAD cofactor." +"1.14.13.249","Requires FAD. The CreL enzyme from the bacterium Streptomyces cremeus participates in the biosynthesis of cremeomycin. The PrmB3 and PtnB3 enzymes from Streptomyces platensis are involved in the biosynthesis of platensimycin and platencin, respectively." +"1.14.13.250","The enzyme, characterized from the bacterium Streptomyces achromogenes subsp. streptozoticus, catalyses a complex multi-step reaction during the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin. The overall reaction is an oxidative rearrangement of the guanidine group of Nomega-methyl-L-arginine, generating an N-nitrosourea product. The enzyme hydroxylates its substrate at the Ndelta position, followed by a second hydroxylation at the Nomega' position. It then catalyses an oxidative rearrangement to form Ndelta-hydroxy-Nomega-methyl-Nomega-nitroso-L-citrulline. This product is unstable, and degrades non-enzymically into nitric oxide and the denitrosated product Ndelta-hydroxy-Nomega-methyl-L-citrulline. The enzyme contains two active sites, each of which utilizes a different iron-containing cofactor." +"1.16.3.4","The enzyme, characterized from the bacterium Escherichia coli, is involved in copper tolerance under aerobic conditions. The enzyme contains a substrate binding (type 1) copper site and a trinuclear copper center (consisting of type 2 and type 3 copper sites) in which oxygen binding and reduction takes place. It also contains a methionine rich region that can bind additional copper ions. In vitro, if the substrate binding site is occupied by copper(II), the enzyme can function as a laccase-type quinol oxidase (EC 1.10.3.2). However, in vivo this site is occupied by a copper(I) ion and the enzyme functions as a cuprous oxidase." +"2.1.1.380","The enzyme, characterized from the bacterium Streptomyces cremeus, is involved in cremeomycin biosynthesis." +"2.1.1.381","The enzyme, characterized from the bacterium Streptomyces achromogenes subsp. streptozoticus, participates in the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin." +"2.1.1.383","The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-carnitine to tetrahydrofolate, as part of an L-carnitine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway." +"2.1.3.16","The enzyme, characterized from the bacterium Rubrobacter xylanophilus, is involved in a purine degradation pathway." +"2.3.1.305","The enzyme is found in bacterial species whose lipid A contains 2,3-diamino-2,3-dideoxy-D-glucopyranose. Some enzymes, such as that from Leptospira interrogans, are highly specific for 2,3-diamino-2,3-dideoxy-D-glucopyranose, while others, such as the enzyme from Acidithiobacillus ferrooxidans, are also able to accept UDP-N-acetyl-alpha-D-glucosamine (cf. EC 2.3.1.129, acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase). The enzymes from different organisms also differ in their specificity for the acyl donor. The enzyme from Leptospira interrogans is highly specific for (3R)-3-hydroxydodecanoyl-[acp], while that from Mesorhizobium loti functions almost equally well with 10-, 12-, and 14-carbon 3-hydroxyacyl-[acp]s." +"2.3.1.306","The enzyme catalyses the first step of an L-lysine degradation pathway found in many fungal species. The enzyme is specific for acetyl-CoA as the acetyl donor. cf. EC 2.3.1.32, lysine N-acetyltransferase." +"2.3.1.307","The enzyme, characterized from the bacterium Streptacidiphilus griseoplanus, participates in the biosynthesis of the tripeptide alazopeptin." +"2.3.3.21","One of the enzymes involved in a pyruvate-derived pathway for isoleucine biosynthesis that is found in some bacterial and archaeal species [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2]. " +"2.4.1.385","The enzyme, isolated from the plant Withania somnifera (ashwagandha), transfers D-glucose to a beta-hydroxyl group present at the C-27 position in sterols/withanolides, provided the substrate possesses a 17alpha-OH group. Natural substrates are 17alpha-hydroxywithaferin A, 27beta-hydroxywithanone, and 5alpha,6beta,17alpha,27beta-tetrahydroxywithanolide. The enzyme's activity with withanolide A and withanolide U, which lack a 17alpha-hydroxyl group, suggests it may also be able to glucosylate the C-20 beta-OH position, although this has not been verified yet. The enzyme does not glucosylate sterols at the C-3 position." +"2.4.1.386","Involved in the production of milk oligosaccharides in the lacto-N-triose (LNT) series. Cf. EC 2.4.1.150 (N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase; cIGnT) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase). " +"2.6.1.120","The enzyme, found in many Gram-positive bacteria, participates in the reductive degradation of pyrimidines. In eukaryotes this activity is catalysed by EC 2.6.1.19, 4-aminobutyrate---2-oxoglutarate transaminase." +"2.6.1.121","The enzyme, which participates in biotin biosynthesis, is found in haloarchaea and some cyanobacteria. It forms a conjugant between (7R,8S)-8-amino-7-oxononanoate and an internal lysine residue and catalyses multiple reactions, including a reduction, a carboxylation of the epsilon-amino group of the lysine residue, and an oxidative cleavage of the conjugate to release (7R,8S)-8-amino-7-(carboxyamino)nonanoate. During this process the lysine residue serves as an amino donor and is converted to (S)-2-amino-6-oxohexanoate, resulting in inactivation of the enzyme following a single turnover. cf. EC 2.6.1.105, lysine---8-amino-7-oxononanoate transaminase. " +"2.6.1.122","This bacterial enzyme participates, together with EC 1.1.1.374, UDP-N-acetylglucosamine 3-dehydrogenase, in the synthesis of 2,3-diamino-2,3-dideoxy-D-glucopyranose, a component of lipid A in some species." +"2.6.1.123","The enzyme, characterized from the bacterium Bacillus subtilis, is a heterodimer. The PabA subunit acts successively on two molecules of L-glutamine, hydrolysing each to L-glutamate and ammonia (cf. EC 3.5.1.2, glutaminase). The ammonia molecules are channeled to the active site of PabB, which catalyses the formation of 4-amino-4-deoxychorismate from chorismate in two steps via the intermediate 2-amino-4-deoxychorismate. cf. EC 2.6.1.85, aminodeoxychorismate synthase." +"2.7.1.234","The enzyme, which has been purified from the bacteria Klebsiella oxytoca and Bacillus licheniformis, is part of a D-tagatose catabolic pathway. The substrate, which occurs in a pyranose form in solution, undergoes a change to the furanose conformation after binding to the enzyme, in order to permit phosphorylation at C-6." +"2.7.1.235","The enzyme catalyses the phosphorylation of L-glycero-D-manno-heptose I (the first heptose added to the lipid, Hep I) in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of some Gram-negative bacteria." +"2.7.7.107","This bacterial enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids, much like EC 2.7.7.15, choline-phosphate cytidylyltransferase, activates phosphocholine for the same purpose." +"2.7.10.3","This family of enzymes includes most of the bacterial tyrosine kinases. These enzymes do not share sequence or structural homology with eukaryotic tyrosine kinases, and exploit ATP/GTP-binding Walker motifs to catalyse autophosphorylation and substrate phosphorylation on tyrosine. Two subfamilies have been defined: P-type enzymes contain an N-terminal transmembrane portion and an extracellular hairpin loop domain. The intracellular portion comprises the catalytic domain and a tyrosine-rich C-terminal domain that contains the site for autophosphorylation. In F-type enzymes the extracellular transmembrane domain and the intracellular catalytic domain are two independent proteins encoded by two separate genes. The majority of characterized bacterial tyrosine kinases regulate the production and export of capsular and extracellular polysaccharides, but other members are involved in many other functions." +"2.8.4.6","The enzyme, characterized from the bacterium Rhodospirillum rubrum, belongs to the cupin superfamily and contains a manganese ion. It participates in an anaerobic salvage pathway that restores methionine from S-methyl-5'-thioadenosine. The enzyme was assayed in vitro using L-dithiothreitol instead of glutathione." +"3.1.7.13","The enzyme, characterized from Glycine max (soybeans), is specific for neryl diphosphate." +"3.2.1.215","The enzyme, characterized from the bacterium Bifidobacterium longum, specifically hydrolyses alpha-D-Galp-(1->3)-L-Araf disaccharides from the non-reducing terminal of arabinogalactan using an exo mode of action. It is particularly active with gum arabic arabinogalactan, a type II arabinogalactan produced by acacia trees. The enzyme can also hydrolyse beta-L-Arap-(1->3)-L-Araf disaccharides, but this activity is significantly lower." +"3.4.17.25","The enzyme participates in a glutathione-mediated detoxification pathway found in plants, algae, fungi, and some bacteria. The enzymes from the plant Arabidopsis thaliana and the yeast Saccharomyces cerevisiae also catalyse the activity of EC 2.3.2.15, glutathione gamma-glutamylcysteinyltransferase (phytochelatin synthase)." +"3.5.1.137","The enzyme catalyses the first step in the degradation of several carbamate insecticides such as carbaryl, carbofuran, isoprocarb, propoxur, aldicarb and oxamyl. It catalyses the cleavage of the ester bond to release N-methylcarbamate, which spontaneously hydrolyses to methylamine and CO2. The enzymes from several Gram-negative bacteria were shown to be located in the periplasm." +"4.2.1.178","The enzyme participates in an inulin degradation pathway, in which it forms inulobiose from difructose anhydride III. A conformational change in the enzyme from the bacterium Pseudarthrobacter chlorophenolicus results in it also catalysing the activity of EC 4.2.2.18, inulin fructotransferase (DFA-III-forming)." +"4.2.1.179","The enzyme, studied in the fungus Aspergillus fumigatus, may participate in an inulin degradation pathway in which it converts the product of EC 4.2.2.17, inulin fructotransferase (DFA-I-forming), to inulobiose, though in vitro activity was higher in the direction of DFA-I formation." +"4.3.99.5","The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites." +"4.8.1.1","Contains a heme b cofactor. The enzyme, characterized from the bacterium Kutzneria sp. 744, is one of very few enzymes known to result in the formation of an N-N bond. (3S)-1,2-diazinane-3-carboxylate (piperazate) is known to be incorporated into assorted secondary products that are produced by nonribosomal peptide synthetase or nonribosomal peptide synthetase/polyketide synthase hybrid pathways, such as the kutznerides, padanamides, himastatins, and sanglifehrins." +"4.8.1.2","The enzyme from Pseudomonas chlororaphis contains Ca2+ and protoheme IX, the iron of which must be in the form iron(II) for activity. The enzyme exhibits a strong preference for aliphatic aldoximes, such as butyraldoxime and acetaldoxime, over aromatic aldoximes, such as pyridine-2-aldoxime, which is a poor substrate. No activity was found with the aromatic aldoximes benzaldoxime and pyridine-4-aldoxime." +"4.8.1.4","The enzyme from Bacillus sp. OxB-1 contains protoheme IX, the iron of which must be in the form iron(II) for activity. (Z)-Phenylacetaldoxime binds to ferric heme (the iron(III) form) via the oxygen atom whereas it binds to the active ferrous form via the nitrogen atom. In this way, the oxidation state of the heme controls the coordination stucture of the substrate---heme complex, which regulates enzyme activity [2]. The enzyme is active towards several (Z)-arylacetaldoximes and (E/Z)-alkylaldoximes as well as towards arylalkylaldoximes such as 3-phenylpropionaldoxime and 4-phenylbutyraldoxime. However, it is inactive with phenylacetaldoximes that have a substituent group at an alpha-site of an oxime group, for example, with (E/Z)-2-phenylpropionaldoxime and (E/Z)-mandelaldoxime. The activity of the enzyme is inhibited completely by the heavy-metal cations Cu+, Cu2+, Ag+ and Hg+ whereas Fe2+ and Sn2+ have an activatory effect." +"4.98.1.1",The enzyme catalyses the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria. The reaction is catalysed only in the reverse direction. +"5.3.99.12","The enzyme is responsible for production of the irritating lachrymatory factor that is released by onions and related species when they are chopped. It acts on the product of EC 4.4.1.4, alliin lyase. The enzyme from Allium cepa (onion) acts on (E)-prop-1-en-1-SO-peroxol and produces (Z)-propanethial oxide, while the enzyme from Allium siculum (honey garlic) acts on (E)-but-1-en-1-SO-peroxol and produces (Z)-butanethial oxide." +"5.6.2.3","The activity is stimulated by DNA polymerase III. As the lagging ssDNA is created, it becomes coated with S Single-Stranded DNA Binding protein (SSB). Once every 500-2000 nucleotides, primase is stimulated by DnaB helicase to synthesize a primer at the replication fork. This primer is elongated by the lagging strand half of DNA polymerase III holoenzyme." +"5.6.2.4","Helicases are motor proteins that can transiently catalyse the unwinding of energetically stable duplex DNA or RNA molecules by using ATP hydrolysis as the source of energy (although other nucleoside triphosphates can replace ATP in some cases). DNA helicases unwind duplex DNA and are involved in replication, repair, recombination, transcription, pre-rRNA processing, and translation initiation. Mechanistically, DNA helicases are divided into those that can translocate in the 3'-5' direction and those that translocate in the 5'-3' direction with respect to the strand on which they initially bind. This entry describes a number of DNA helicases that translocate in the 3'-5' direction. Many of the enzymes require a 3' single-stranded DNA tail. The Rep protein is a component of the bacterial replisome, providing a replication fork-specific motor. The UvrD enzyme, found in Gram-negative bacteria, is involved in maintenance of chromosomal integrity. The RecQ proteins are a family of eukaryotic helicases that are involved in DNA replication, transcription and repair. The Mer3 helicase, found in fungi and plants, is required for crossover formation during meiosis. cf. EC 5.6.2.3, DNA 5'-3' helicase." +"6.3.2.61","The eukaryotic tubulin proteins, which polymerize into microtubules, are highly modified by the addition of side-chains. The polyglutamylation reaction catalysed by this group of enzymes consists of two biochemically distinct steps: initiation and elongation. Initiation comprises the formation of an isopeptide bond with the gamma-carboxyl group of the glutamate acceptor site in a glutamate-rich C-terminal region of tubulin, whereas elongation consists of the addition of glutamate residues linked by regular peptide bonds to the gamma-linked residue. This entry describes enzymes that act on both alpha- and beta-tubulins." +"6.3.2.62","The eukaryotic tubulin proteins, which polymerize into microtubules, are highly modified by the addition of side-chains. The polyglutamylation reaction catalysed by this group of enzymes consists of two biochemically distinct steps: initiation and elongation. Initiation comprises the formation of an isopeptide bond with the gamma-carboxyl group of the glutamate acceptor site, whereas elongation consists of the addition of glutamate residues linked by regular peptide bonds to the gamma-linked residue. This entry describes enzymes that act on beta-tubulins and other proteins with glutamate-rich regions but not on alpha-tubulins." +"6.7.1.1","The enzyme, characterized from Streptomyces cremeus, catalyses the last step in the biosynthesis of the ortho-diazoquinone cremeomycin." +"1.1.1.427","The enzyme from the archaeon Saccharolobus solfataricus is tetrameric and contains zinc. L-fucose also is a substrate. In contrast to EC 1.1.1.116 (D-arabinose 1-dehydrogenase (NAD+)) and EC 1.1.1.117 (D-arabinose 1-dehydrogenase [NAD(P)+]), this enzyme is specific for NADP+." +"1.1.1.428","The substrate of this enzyme is formed as an intermediate during L-methionine salvage from S-methyl-5'-thioadenosine, which is formed during the biosynthesis of polyamines. The human enzyme also functions as a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes, thus providing a link between gene repression and the methionine salvage pathway. A similar, but NADP-specific, enzyme is involved in dimethylsulfoniopropanoate biosynthesis in algae and phytoplankton." +"1.1.1.429","The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway. It is specific for NAD+." +"1.3.3.17","The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminobenzyl)malonyl-CoA. " +"1.3.99.41","The enzyme, found in marine bacteria, participates in a 3-(methylsulfanyl)propanoate degradation pathway. Based on similar enzymes, the in vivo electron acceptor is likely electron-transfer flavoprotein (ETF)." +"1.5.3.24","The enzyme, found in some bacterial species, is composed of four different subunits and two active sites connected by a large ""reaction chamber"". An imine intermediate is transferred between the sites, eliminating the production of toxic formaldehyde. The enzyme contains three cofactors: noncovalently bound FAD and NAD+, and FMN that is covalently bound to a histidine residue. In the absence of folate the enzyme catalyses the reaction of EC 1.5.3.1, sarcosine oxidase (formaldehyde-forming)." +"1.14.14.178","This plant cytochrome P-450 (heme thiolate) enzyme participates in the biosynthesis of brassinosteroids. While in vivo substrates include C28 steroids such as campestanol, campesterol, and 6-oxocampestanol, the enzyme is able to catalyse the C-22 hydroxylation of a variety of C27, C28 and C29 steroids." +"1.14.19.79","This cytochrome P-450 (heme-thiolate) enzyme, characterized from the plant Arabidopsis thaliana, catalyses C-3 dehydrogenation of all 3beta-hydroxy brassinosteroid synthesis intermediates with 22-hydroxylated or 22,23-dihydroxylated side chains." +"2.3.1.308","The enzyme, characterized from the fruit fly (Drosophila melanogaster), acetylates the N-terminal of both alpha- and beta-tubulin. The enzyme acts cotranslationally, and can't act on a preformed tubulin alpha/beta heterodimer." +"2.4.1.387","The enzyme, found in bacteria that produce cyclobis-(1->6)-alpha-nigerosyl, acts on the products of EC 2.4.1.24, 1,4-alpha-glucan 6-alpha;-glucosyltransferase. It catalyses the alpha-(1->3) transfer of the isomaltosyl moiety of one substrate to another, resulting in alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-alpha-(1->4)-glucan formation. In addition, the enzyme catalyses the intramolecular cyclization of the product, eventually generating cyclobis-(1->6)-alpha-nigerosyl." +"2.4.1.388",The enzyme from the bacterium Paenibacillus polymyxa belongs to glycoside hydrolase family 94. It has a much lower activity with 4-O-beta-D-glucosyl-L-arabinose. +"2.4.3.1",The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids. +"2.4.3.2","The enzyme recognizes the sequence beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl (known as type 1 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids [1]. When acting on gangloside GM1a, it forms gangloside GD1a [2]." +"2.4.3.3","N-acetyl-alpha-D-galactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position." +"2.4.3.4","The acceptor is Galbeta1,3GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid. Lactose can also act as acceptor. May be identical with EC 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase." +"2.4.3.5",The beta-D-galactosyl residue of the oligosaccharide of glycoproteins may also act as acceptor. +"2.4.3.6","The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids. The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1 [2]." +"2.4.3.7","Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetylgalactosamine only when present in the structure of alpha-N-acetylneuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.3.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase." +"2.4.3.8",Gangliosides act as acceptors. +"2.4.3.9",Lactose cannot act as acceptor. +"2.4.3.10","Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-beta-D-glucosamine. The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl residues, but more slowly." +"2.7.1.236","The enzyme, best characterized from the plant pathogenic bacterium Xanthomonas oryzae pv. oryzicola, is considered a bacterial type III effector. The product, 3'-NADP, is believed to enhance bacterial virulence on plants through manipulation of primary metabolic pathways. In vitro the enzyme is also active with nicotinate adenine dinucleotide (deamido-NAD)." +"2.8.3.27","The enzyme is most specific in Escherichia coli, where the preferred substrates are propanoyl-CoA and succinate. In other organisms, the enzyme uses acetyl-CoA at the same rate as propanoyl-CoA (cf. EC 2.8.3.18, succinyl-CoA:acetate CoA-transferase)." +"2.8.3.28","The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminophenyl)succinate. It has a broad substrate specificity towards other C4-dicarboxylic acids, phenylacetate, and the non-physiological compound 2-naphthylacetate. The enzyme produces 2- and 3-phenylsuccinyl-CoA in equimolar amounts. It can also perform an intramolecular transfer of the CoA moiety to convert 2-phenylsuccinyl-CoA to 3-phenylsuccinyl-CoA." +"3.2.1.216","The enzyme, characterized from the bacteria Flavobacterium johnsoniae and Mucilaginibacter mallensis, uses anomer-inverting mechanism to release beta-glucose from the non-reducing ends of kojibiose and alpha-1,2-oligoglucans with a higher degree of polymerization." +"4.2.1.180","The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway in which it catalyses the hydration of (E)-benzylidenesuccinyl-CoA." +"6.2.1.75","The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate. It is also active with phenylacetate and the non-physiological compound (2-naphthyl)acetate." +"3.2.1.217","The enzyme, which belongs to the glycosylhydrolase 31 (GH31) family, is an exo-acting alpha-N-acetylgalactosaminidase that acts on the innermost alpha-GalNAc residues at the core of O-glycans when no other saccharides are attached to it. Unlike EC 3.2.1.49, alpha-N-acetylgalactosaminidase, it is not able to act on blood group A antigen." +"3.1.1.119","The enzyme, which belongs to the glycosylhydrolase 31 (GH31) family, is an exo-acting alpha-N-acetylgalactosaminidase that acts on the innermost alpha-GalNAc residues at the core of O-glycans when no other saccharides are attached to it. Unlike EC 3.2.1.49, alpha-N-acetylgalactosaminidase, it is not able to act on blood group A antigen." +"1.1.1.430","Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH (cf. EC 1.1.1.431, D-xylose reductase (NADPH)). Some D-xylose reductases have dual cosubstrate specificity, though they still prefer NADPH to NADH (cf. EC 1.1.1.307, D-xylose reductase [NAD(P)H]). The enzyme from Candida parapsilosis is a rare example of a xylose reductase that significantly prefers NADH, with Km and Vmax values for NADH being 10-fold lower and 10-fold higher, respectively, than for NADPH." +"1.1.1.431","Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH (e.g. the enzymes from Saccharomyces cerevisiae, Aspergillus niger, Trichoderma reesei, Candida tropicalis, Saitozyma flava, and Candida intermedia). Some D-xylose reductases have dual cosubstrate specificity, though they still prefer NADPH to NADH (cf. EC 1.1.1.307, D-xylose reductase [NAD(P)H]). Very rarely the enzyme prefers NADH (cf. EC 1.1.1.430, D-xylose reductase (NADH))." +"1.1.1.432","The enzyme, characterized from alphaproteobacteria, is involved in a D-sulfoquinovose degradation pathway." +"1.1.1.433","The enzymes from the bacteria Bilophila wadsworthia and Clostridium sp. MSTE9 catalyse the reaction only in the reduction direction. In the bacterium Bifidobacterium kashiwanohense the optimal reaction pH for sulfoacetaldehyde reduction is 7.5, while that for isethionate oxidation is 10.0. cf. EC 1.1.1.313, sulfoacetaldehyde reductase (NADPH)." +"1.1.2.11","This bacterial enzyme acts on D-glucose, D-galactose, D-glucosides and D-galactosides, but the best substrates are disaccharides with a glucose moiety at the non-reducing end. It consists of two subunits, a catalytic subunit that contains an FAD cofactor and an iron-sulfur cluster, and a ""hitch-hiker"" subunit containing a signal peptide for translocation into the periplasm. A dedicated c-type cytochrome protein serves as an electron acceptor, transferring the electrons from the catalytic subunit to the cell's electron transfer chain. cf. EC 1.1.99.13, glucoside 3-dehydrogenase (acceptor)." +"1.4.1.28","The enzyme has been shown to react preferentially with short-chain ketones such as cyclohexanone, primary amine groups attached to secondary alkyl groups, or D- and L-amino acids. It also reduces aldehydes to primary amines. Cosubstrate preference depends on the substrate." +"1.5.3.25","Reducing sugars such as glucose react with amino groups in proteins via the spontaeous Maillard reaction, forming an unstable product that undergoes spontaneous rearrangement to a keto amine compound. These reactions are known as glycation reactions, and the stable products are known as Amadori products. This enzyme, which contains an FAD cofactor, catalyses a deglycation reaction that regenerates the amine reactant. By-products are glucosone and hydrogen peroxide. The enzymes have been reported from fungi and bacteria, but not from higher eukaryotes. Specific enzymes differ in their substrate specificity. cf. EC 1.5.3.26, fructosyl amine oxidase (fructosamine-forming)." +"1.5.3.26","Reducing sugars such as glucose react with amino groups in proteins via the spontaeous Maillard reaction, forming an unstable product that undergoes spontaneous rearrangement to a keto amine compound. These reactions are known as glycation reactions, and the stable products are known as Amadori products. This enzyme, characterized from a Pseudomonas sp. strain, cleaves the Amadori products at the alkylamine bond. All other known fructosyl amine oxidases cleave the ketoamine bond (cf. EC 1.5.3.25, fructosyl amine oxidase (glucosone-forming))." +"1.5.7.3","This bacterial enzyme is involved in degradation of glycine betaine. The enzyme contains non-covalently bound FAD and NAD(P) cofactors, and catalyses the demethylation of both N,N-dimethylglycine and sarcosine, releasing formaldehyde and forming glycine as the final product. The enzyme can utilize both NAD+ and NADP+, but the catalytic efficiency with NAD+ is ~5-fold higher. The native electron acceptor of the enzyme is a membrane-bound clostridial-type ferredoxin, which transfers the electrons to an electron-transfer flavoprotein (ETF)." +"1.13.11.93","The enzyme, characterized from the bacterium Pseudomonas putida, is involved in an L-lysine catabolic pathway. Contains Fe(II)." +"1.14.11.78","Requires Fe(II). The enzyme, found in actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. The reaction comprises two catalytic cycles, each consuming an oxygen molecule and a 2-oxoglutarate molecule. In the first cycle the substrate is hydroxylated, while in the second cycle the enzyme catalyses a decarboxylation/oxidation reaction that produces an isonitrile group." +"1.14.11.79","The human enzymes encoded by the RIOX1 and RIOX2 genes catalyse the hydroxylation of L-histidine residues in the 60S ribosomal proteins Rpl8 and L27a, respectively. Both proteins contain JmjC and winged helix domains, and both also catalyse histone L-lysine demethylation activities." +"1.14.13.251","The enzyme, characterized from the bacteria Pseudomonas aeruginosa and Chromohalobacter salexigens, is involved in a degradation pathway of glycine betaine. It is composed of two subunits - a ferredoxin reductase component that contains FAD, and a terminal oxygenase component that contains a [2Fe-2S] Rieske-type iron-sulfur cluster and a nonheme iron centre." +"1.14.14.179","This cytochrome P-450 (heme thiolate) plant enzyme catalyses the C-6 hydoxylation of several brassinosteroid biosynthesis intermediates, and the further oxidation of the hydroxyl group to an oxo group. Substrates include 6-deoxocastasterone, 6-deoxotyphasterol, 3-dehydro-6-deoxoteasterone, and 6-deoxoteasterone. The CYP85A2 isozyme of Arabidopsis thaliana (but not the CYP85A1 isozyme) also catalyses the activity of EC 1.14.14.180, brassinolide synthase." +"1.14.14.180","This cytochrome P-450 (heme thiolate) plant enzyme catalyses the lactonization of several brassinosteroids, including castasterone, teasterone, and typhasterol. The CYP85A2 enzyme of Arabidopsis thaliana also catalyses the activity of EC 1.14.14.179, brassinosteroid 6-oxygenase." +"1.14.14.181","The enzyme, characterized from the bacteria Agrobacterium fabrum and Rhizobium oryzae, is involved in a D-sulfoquinovose degradation pathway. FMNH2 is provided by an associated FMN reductase [SmoA, EC 1.5.1.42, FMN reductase (NADH)]." +"1.14.14.182",A cytochrome P-450 (heme-thiolate) protein from the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis. +"1.14.14.183",A cytochrome P-450 (heme-thiolate) protein from the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis. +"1.21.3.10","Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine." +"2.1.1.382","This entry stands for a family of enzymes that have been characterized from acetogenic bacteria and archaeal species. Different members of this family have different substrate specificity. In the methanogenic archaeon Methermicoccus shengliensis the enzyme participates in methanogenesis from methoxylated aromatic compounds, while in acetogenic bacteria and in non-methanogenic archaea it participates in methoxydotrophic growth. Most of the enzymes have a wide specificity and were shown to act on a large number of methoxylated aromatic compounds, carrying a methoxy group at positions 2, 3 or 4 of the aromatic ring. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state; during methylation the cobalt is oxidized to the Co(III) state." +"2.1.1.384","The enzyme has been characterized from several archaeal species. In the methanogenic archaeon Methermicoccus shengliensis the enzyme participates in methanogenesis from methoxylated aromatic compounds, while in the non-methanogenic Archaeoglobus fulgidus it participates in methoxydotrophic growth. The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (MtoC) to tetrahydromethanopterin or tetrahydrosarcinapterin. cf. EC 2.1.1.385, [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydrofolate methyltransferase." +"2.1.1.385","The enzyme, found in acetogenic bacteria, participates in a pathway for the degradation of methoxylated aromatic compounds (methoxydotrophic growth). The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (MtvC) to tetrahydrofolate. cf. EC 2.1.1.384, [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]---tetrahydromethanopterin methyltransferase." +"2.2.1.15","The enzyme, characterized from the bacterium Clostridium sp. MSTE9, is involved in a D-sulfoquinovose degradation pathway. " +"2.4.1.389","The enzyme, characterized from the bacterium Paenibacillus borealis, belongs to glycoside hydrolase family 94 (GH94)." +"2.4.99.23",The enzyme catalyses a glycosylation step in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of many Gram-negative bacteria. +"2.4.99.24",The enzyme catalyses a glycosylation step in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of some Gram-negative bacteria. +"2.4.99.25",The enzyme catalyses a glycosylation step in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of some Gram-negative bacteria. +"2.5.1.155","The enzyme, characterized from the archaeon Aeropyrum pernix, catalyses the first pathway-specific step in the biosynthesis of the core membrane C25,C25-diether lipids in some archaea. It does not act on geranylgeranyl diphosphate. cf. EC 2.5.1.41, phosphoglycerol geranylgeranyltransferase." +"2.5.1.156","The enzyme, characterized from the archaeon Aeropyrum pernix, carries out the second prenyltransfer reaction involved in the formation of C25,C25 membrane diether-lipids in some archaea. Requires a divalent metal cation, such as Mg2+. The enzyme cannot accept sn-3-(O-geranylgeranyl)glycerol 1-phosphate as the prenyl donor. cf. EC 2.5.1.42, geranylgeranylglycerol-phosphate geranylgeranyltransferase." +"2.6.1.124","The enzyme participates in an L-arginine biosynthetic pathway that operates in certain species of archaea. In some cases the enzyme also catalyses the activity of EC 2.6.1.118, [amino-group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase." +"2.7.1.237","The enzyme, characterized from the archaeon Thermococcus kodakarensis, participates in a coenzyme A biosynthesis pathway. cf. EC 2.7.1.24, dephospho-CoA kinase." +"2.7.1.238","The enzyme, characterized from the bacterium Thauera aromatica, catalyses the first step in an anaerobic phenol degradation pathway. The enzyme, composed of three subunits, transfers the beta-phosphoryl from ATP to phenol, forming phenyl phosphate, AMP, and phosphate [1]. During catalysis a diphosphoryl group is transferred from ATP to a histidine residue in one of the enzyme's subunits, from which phosphate is cleaved to render the reaction unidirectional. The remaining histidine phosphate subsequently serves as the actual phosphorylation agent [2]." +"2.7.2.19","The enzyme participates in an L-arginine biosynthetic pathway in certain species of archaea. In some organisms the enzyme also catalyses the activity of EC 2.7.2.17, [amino-group carrier protein]-L-2-aminoadipate 6-kinase." +"2.7.11.34","Requires Mg2+. NEK6 subfamily kinases are present in animals, though lost in insects, and include human NEK6 and NEK7 and C. elegans nekl-3. They are activated in mitosis by phosphorylation by NEK9 [1], and phosphorylate cytoskeletal proteins including EML4, KIF11A and KIF14 [4,2]. In C. elegans, nekl-3 is involved in clathrin-mediated endocytosis [5]. In peptide arrays, NEK6 prefers to phosphorylate Ser residues, with hydrophobic residues at -2 and +1 and charged residues at -1, -2 and +2 [3]." +"3.4.21.122","The enzyme, present in mammalia, cleaves and inactivates EC 3.4.17.23, angiotensin-converting enzyme 2 (ACE2), at arginine residues in the region R697 to R716, which enhances influenza and coronavirus uptake [7]. The enzyme also cleaves and activates influenza and coronavirus spike glycoproteins and thus facilitates virus-cell membrane fusions. The cleavage of SARS-COV2 spike glycoprotein occurs between the S2 and S2' site at SKPSKR/SFIEDL, while the cleavage of MERS-COV glycoprotein occurs at GSRSAR/SAIEDL." +"3.13.2.1","The enzyme contains one tightly bound NAD+ per subunit. This appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond [2] (for mechanism, click here), cf. EC 5.5.1.4, inositol-3-phosphate synthase." +"3.13.2.2","Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC 3.13.2.3, (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming)." +"3.13.2.3","The enzyme, found in bacteria and archaea, is involved in removing the (R) isomer of S-adenosyl-L-methionine from the cell. It catalyses a nucleophilic attack of water at the C5' carbon of S-adenosyl-L-methionine to generate adenosine and L-methionine." +"4.1.1.122","Requires pyridoxal 5'-phosphate. The enzyme, characterized from chicken, is specific for L-cysteate and has poor activity with 3-sulfino-L-alanine. cf. EC 4.1.1.29, sulfinoalanine decarboxylase." +"4.1.1.123","The enzyme, characterized from the bacterium Thauera aromatica, participates in an anaerobic phenol degradation pathway. It catalyses the para dephosphorylation and carboxylation of phenylphosphate to 4-hydroxybenzoate. The enzyme from Thauera aromatica consists of four different subunits and requires K+ and a divalent metal cation (Mg2+ or Mn2+) for activity. It is strongly inhibited by oxygen." +"4.6.1.26","The enzyme, found in bacteria and archaea, forms cUMP, which functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response." +"5.3.1.37","The enzyme, characterized from the bacterium Clostridium sp. MSTE9, is involved in a D-sulfoquinovose degradation pathway." +"7.1.1.12","The enzyme is very similar to EC 1.3.5.1, succinate dehydrogenase, but differs by containing two heme molecules (located in the membrane anchor component) in addition to FAD and three iron-sulfur clusters. Unlike EC 1.3.5.1, this enzyme catalyses an electrogenic reaction, enabled by electron-bifurcation via the heme molecules. In the direction of succinate oxidation by menaquinone, which is endergonic, the reaction is driven by the transmembrane electrochemical proton potential. In the direction of fumarate reduction, the electrogenic electron transfer reaction is compensated by transmembrane proton transfer pathway known as the E-pathway, which results in overall electroneutrality." +"1.1.3.50","A flavoprotein (FAD). This bacterial enzyme participates in degradation of certain C-glucosides by catalysing the oxidation of the hydroxyl group at position 3 of the glycose moiety. The enzyme was found active with assorted C-glycosides, such as carminate, mangiferin, and C6-glycosylated flavonoids, but not with D-glucose or C8-glycosylated flavonoids." +"2.3.1.309","The enzyme acetylates L-lysine at position 252 of beta-tubulin, which is located at the interface of alpha/beta-tubulin heterodimers and interacts with the phosphate group of the alpha-tubulin-bound GTP. The acetylation is thought to attenuate tubulin incorporation into microtubules. The enzyme catalysing this activity (NAA50) also catalyses the acetylation of certain N-terminal methionyl residues. That activity is classified as EC 2.3.1.258, N-terminal methionine Nalpha-acetyltransferase NatE. cf. EC 2.3.1.108, alpha-tubulin N-acetyltransferase." +"2.3.1.310","The enzyme, characterized from the bacteria Thauera aromatica and Geobacter metallireducens, participates in an anaerobic toluene degradation pathway." +"2.7.7.108","The enzyme, commonly referred to as AMPylase, transfers an adenylyl (adenosine 5'-phosphate) group from ATP to L-serine, L-threonine, and L-tyrosine residues in its target protein substrates. AMPylation is found in both prokaryotes and eukaryotes. In bacteria AMPylases are abundant enzymes that either regulate the function of endogenous bacterial proteins or are translocated into host cells to hijack host cell signalling processes. Metazoans AMPylases are either enzymes containing a conserved Fic domain that primarily modify the ER-resident chaperone BiP, or mitochondrial selenocysteine-containing proteins (SelO) involved in redox signalling." +"3.6.1.75","The bifunctional enzyme catalyses the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. phosphatidate phosphatase (EC 3.1.3.4)). It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signalling role in stress response [6]. The phosphatase activity of the bifunctional enzyme is Mg2+-independent and N-ethylmaleimide-insensitive and is distinct from the Mg2+-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4 (phosphatidate phosphatase) [5].The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase [4]. " +"4.3.2.11","The enzyme, found in some actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. It catalyses the formation of (3R)-3-[(carboxylmethyl)amino]fatty acid by the addition of glycine and the release of the product from the acyl-carrier protein." +"6.2.1.76","The enzyme, found in mitochondria, detoxifies malonate, which is a potent inhibitor of mitochondrial respiration, and provides malonyl-CoA to the mitochondrial fatty acid biosynthesis pathway." +"1.1.1.434","The enzyme, originally described from the bacterium Xanthomonas campestris pv. campestris, participates in an L-fucose degradation pathway. It can also act on 2-dehydro-3-deoxy-L-galactonate and 2-dehydro-3-deoxy-D-pentonate." +"1.1.1.435","The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme catalyses the oxidation of beta-L-fucopyranose to L-fucono-1,5-lactone, which is unstable and is rapidly converted to L-fucono-1,4-lactone. The alpha anomer is not recognized. The enzyme can also act on beta-L-galactopyranose and D-arabinose with lower activity. NADP+ is a better cosubstrate than NAD+." +"1.1.1.436","The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+. " +"1.1.1.437","The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin. It is a partial polyketide synthase (PKS) consisting of only a dehydratase (DH) and a ketoreductase (KR) domain." +"1.3.1.125","The enzyme, characterized from the marine bacterium Vibrio harveyi, enables the organism to utilize acrylate as the terminal electron acceptor for NADH regeneration under anaerobic conditions." +"1.3.2.4","Contains a non-covalently bound FAD cofactor and four heme c groups. The enzyme, characterized from the bacterium Shewanella frigidimarina, is a soluble periplasmic protein that functions as a terminal electron acceptor during anaerobic growth. The direct electron donor is the membrane-bound tetraheme c-type cytochrome CymA (EC 7.1.1.8, quinol---cytochrome-c reductase), which receives the electrons from the membrane quinol pool." +"1.4.2.2","The enzyme, characterized from the bacterium Pseudomonas putida S16, contains an FAD cofactor and belongs to the flavin-containing amine oxidase family. The enzyme from this bacterium is specific for the c-type cytochrome CycN. The product undergoes spontaneous hydrolysis to form pseudooxynicotine." +"1.4.2.3","Contains one non-covalently bound FAD molecule per dimer. This enzyme, characterized from the soil bacteria Pseudomonas sp. HZN6 and Pseudomonas putida S16, is involved in nicotine degradation." +"1.4.3.27",The copper-containing enzyme has been isolated from the plant Heliotropium indicum. It is involved in the biosynthesis of the pyrrolizidine alkaloid (-)-trachelanthamidine which acts as a secondary metabolite for the defense against herbivores. The oxidation of sym-homospermidine proceeds in three steps and results in a cyclization. +"1.14.11.80","The TET proteins mediate iterative oxidation of 5-methylcytosine in DNA (5mc) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). 5fC and 5caC are recognized by EC 3.2.2.29, thymine-DNA glycosylase (TDG), which excises them, leaving an apyrimidinic site. Coupled with the base excision repair (BER) pathway, these activities result in a cytosine demethylation pathway." +"1.14.11.81","This fungal enzyme is involved in the biosynthesis of quinolone compounds. it catalyses two oxidation reactions: the first reaction results in a desaturation; the second reaction is a monooxygenation of the double bond, forming an epoxide. The enzyme is also active with 4'-methoxycyclopeptine." +"1.14.11.82","Requires iron(II). The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin." +"1.14.14.184","The enzyme, characterized from the mold Aspergillus fumigatus, catalyses a complex transformation comprising hydroxylation, bicyclic ring-opening, and two epoxidations, generating the sesquiterpenoid core skeleton of fumagillin." +"1.21.98.5","This archaeal enzyme catalyses a C-C bond formation during the biosynthesis of tetraether lipids. The bond is formed between the termini of two lipid tails from two glycerophospholipids to generate the macrocycle glycerol dibiphytanyl glycerol tetraether (GDGT). The enzyme does not distinguish whether the two lipids are connected in antiparallel or parallel geometry, resulting in formation of two forms of the product, which are known as caldarchaeol and isocaldarchaeol, respectively. The enzyme can also form macrocyclic archaeol phospholipids by joining the two lipid tails of a single substrate molecule. Even though the reaction shown here describes phospholipid substrates, the enzyme can also act on glycolipids or lipids that contains mixed types of polar head groups. The enzyme is a radical SAM enzyme that contains 3 [4Fe-4S] clusters and one mononuclear rubredoxin-like iron ion, each found in a separate domain. The enzyme uses the 5'-deoxyadenosyl radical to initiate the reaction, which involves the formation of an intermediate bond between the substrate carbon and a sulfur of one of the [4Fe-4S] clusters. Two radicals are needed per C-C bond formed. The source of the required additional electrons is not known." +"2.1.1.386","The enzyme adds a 2'-O-methyl group to the ribose of the last nucleotide in several types of small RNAs (sRNAs), protecting the 3'-end of sRNAs from uridylation activity and subsequent degradation." +"2.1.1.387"," The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin." +"2.3.1.311","The enzyme, found in eukaryotes, most archaea, and some bacteria, catalyses the first step in modification of the wobble uridine base of certain tRNAs. In eukaryotes the enzyme is a complex of six conserved subunits, with ELP3 being the catalytic subunit. In archaea and bacteria the enzyme consists of a single subunit, homologous to ELP3. The enzyme contains an [4Fe-4S] cluster and uses radical chemistry. A 5'-deoxyadenosyl radical generated in the radical AdoMet (SAM) domain attacks the acetyl-CoA donor, activating its methyl group, which forms a C-C bond with C5 of the uridine moiety." +"2.4.1.390","The enzyme, characterized from the bacterium Lactobacillus fermentum NCC 2970, possesses hydrolysis and transglycosylase activities on malto-oligosaccharides with a degree of polymerization of at least 6, as well as polymers such as amylose, potato starch, and amylopectin. The enzyme, which belongs to glycoside hydrolase 70 (GH70) family, attaches the glucosyl residues by alpha(1->3) linkages in both linear and branched orientations. While capable of forming large polymers, the enzyme produces mainly oligosaccharides in vitro." +"2.4.1.391","The enzyme, characterized from the bacterium Ignavibacterium album, transfers a glucosyl residue from the non-reducing end of a 1,2-beta-D-glucan to a glucose residue of an acceptor molecule, forming a beta(1,2) linkage. The donor molecule can be as small as sophorose (which contains two glucosyl residues). The enzyme has a very broad specificity for the acceptor, and can act on various aryl- and alkyl-glucosides. In addition, the accepting glucose unit can be in either alpha or beta configuration." +"2.4.1.392","The enzyme, characterized from the bacterium Paenibacillus borealis, catalyses a reversible reaction, transferring a glucosyl residue attached by a beta(1,3) linkage to a D-glucuronate residue (either free or as a part of a beta-D-glucuronide) to a free phosphate, generating alpha-D-glucopyranose 1-phosphate." +"2.7.1.239","The enzyme, characterized from the halophilic archaeon Halopiger xanaduensis, participates in a non-carboxylating pentose bisphosphate pathway for nucleoside degradation, which is found in some halophilic archaea. cf. EC 2.7.1.212, alpha-D-ribose-1-phosphate 5-kinase (ADP)." +"2.7.8.48","The enzyme from invertebrates, best studied from the fly Drosophila melanogaster, is common in arthropods, worms, bees, spiders, and scorpions, and has also been reported in deep-sea mussels and some sea snails, as well as protozoans and oomycetes. Its product, ceramide phosphoethanolamine, is the main sphingolipid in cell membranes of arthropods, such as Drosophila and Musca. The invertebrate enzyme requires a Mn(II) cofactor. In mammals the activity has been shown to be catalysed by members of the EC 2.7.8.27, sphingomyelin synthase, family, such as SGMS1, SGMS2, and SAMD8." +"3.1.1.120","The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme exhibits catalytic activity for the hydrolysis of several lactones, including L-fucono-1,4-lactone, D-arabinono-1,4-lactone, L-xylono-1,4-lactone, and L-galactono-1,4-lactone, but L-fucono-1,5-lactone is the best substrate." +"3.1.3.109","The enzyme, characterized from the halophilic archaeon Halopiger xanaduensis, participates in a non-carboxylating pentose bisphosphate pathway for nucleoside degradation, which is found in some halophilic archaea. The enzyme requires both monovalent and divalent ions for optimal activity." +"3.2.1.218","The enzyme, originally characterized from the bacterium Agrobacterium tumefaciens, is specific for disaccharides that contain a 3-dehydro-alpha-D-glucose at the non-reducing end such as 3'-dehydrosucrose and 3'-dehydro-alpha,alpha-trehalose. It has no activity with disaccharides in which the glucose is in beta conformation, and greatly reduced activity with disaccharides with an unmodified 3' position." +"3.2.1.219","The enzyme, characterized from the bacterium Erwinia rhapontici, is specific for palatinose." +"3.6.1.76","The enzyme, characterized from the methanogenic archaeon Methanosarcina mazei, belongs to the Nudix hydrolase family (a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to a moiety). Its main purpose is to provide the substrate for EC 2.5.1.129, flavin prenyltransferase." +"4.1.99.27","This fungal enzyme catalyses a key reaction in the biosynthesis of quinolone compounds, converting the benzodiazepine structure into a quinolone structure. The enzyme is also active with (-)-4'-methoxycyclopenine." +"4.2.2.28","The enzyme, characterized from the phytopathogenic fungus Fusarium oxysporum, removes the rhamnosyl residue from alpha-L-rhamnosyl-(1->4)-D-glucuronate or (with lower activity) from oligosaccharides that contain this motif at the non-reducing end, leaving an unsaturated glucuronate residue. Among its natural substrates is the type II arabinogalactan component of gum arabic." +"4.2.3.206","The enzyme, characterized from the fungi Hericium erinaceus and Cyathus africanus, requires Mg2+ for activity." +"4.2.3.207",Requires Mg2+. Characterized from the marine bacterium Saprospira grandis. +"4.2.3.208",Requires Mg2+. Characterized from the bacterium Chloroflexus aurantiacus. +"4.2.3.209",Requires Mg2+. Characterized from the bacterium Archangium violaceum. +"4.2.3.210",Requires Mg2+. Characterized from the bacterium Streptomyces lydicus. +"4.2.3.211","The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin." +"4.3.3.8","A pyridoxal 5'-phosphate protein. The enzyme degrades the toxic amino acid L-mimosine. It cleaves a carbon-nitrogen bond, releasing 3-hydroxy-4H-pyrid-4-one and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. It is thought to have evolved from EC 4.4.1.13, cysteine-S-conjugate beta-lyase. It has been described in both mimosine-producing plants and some bacteria." +"4.4.1.42","The enzyme was originally described from the yeast Saccharomyces cerevisiae (as EC 2.5.1.4), though it had not been well characterized. It was also incorrectly described from several bacteriophages as a hydrolase (EC 3.13.2.2). Later work has shown the bacteriophage enzyme to be a lyase. The enzyme binds its substrate at the border between two subunits of a trimeric complex in a position that prevents it from interacting with water. Instead, the substrate reacts with itself and splits in two. The product, L-homoserine lactone, spontaneously hydrolyses to L-homoserine." +"4.4.1.43","A pyridoxal 5'-phosphate protein. The enzyme, characterized from the bacterium Pseudomonas canavaninivorans, cleaves a carbon-oxygen bond, releasing N-hydroxyguanidine and an unstable enamine product that tautomerizes to an imine form, which is attacked by a water molecule to form L-homoserine." +"4.8.1.5","The enzyme is involved in the breakdown of glucosinolates. It can act on both aliphatic and aromatic glucosinolates, and forms nitrile-containing products. cf. EC 4.8.1.6, N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming), and EC 4.8.1.7, phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase." +"4.8.1.6","The enzyme is involved in the breakdown of glucosinolates. It acts only on aliphatic N-(sulfonatooxy)alkenimidothioic acids produced from omega-alkenyl-glucosinolates, and forms epithionitrile-containing products. cf. EC 4.8.1.5, thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming), and EC 4.8.1.7, phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase." +"4.8.1.7","The enzyme, characterized from the plant Lepidium sativum, is involved in the breakdown of the glucosinolate glucotropaeolin. Depending on the substrate, it can also form simple nitrile- and epithionitrile-containing products. cf. EC 4.8.1.5, thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming), and EC 4.8.1.6, N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming)." +"4.8.1.8","The enzyme, characterized from the plant Thlaspi arvense, is involved in the breakdown of the glucosinolate sinigrin. Depending on the substrate, it can also form simple nitrile-containing products. cf. EC 4.8.1.5, thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming) and EC 4.8.1.6, N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming)." +"5.3.3.24","The enzyme, characterized from the opium poppy (Papaver somniferum), participates in the biosynthesis of morphine. It also catalyses the isomerization of neomorphinone and morphinone." +"7.2.3.1","Requires Na+ and K+. This enzyme, found in some bacteria and archaea, couples the energy from diphosphate hydrolysis to active sodium translocation across the membrane. The enzyme is electrogenic, as the Na+ transport results in generation of a positive potential in the inner side of the membrane." +"2.1.1.388","The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-proline betaine to tetrahydrofolate, as part of an L-proline betaine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway." +"2.1.1.389","The enzyme, characterized from the acetogenic gut bacterium Eubacterium limosum, participates in a pathway for the degradation of some quaternary amine compounds (L-proline betaine and L-carnitine). The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (bacterial MtqC) to tetrahydrofolate. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood---Ljungdahl pathway." +"2.1.1.390","The enzyme, isolated from the bacterium Micromonospora echinospora, has a single [4Fe-4S] cluster per monomer. It is a radical S-adenosyl-L-methionine (SAM) enzyme with a methylcob(III)alamin cofactor. The enzyme uses two molecues of SAM for the reaction. One molecule forms a 5'-deoxyadenosyl radical, while the other is used to methylate the cobalamin cofactor. It catalyses methylation of the 6'-carbon of gentamicin X2 (GenX2) to produce genetricin (G418) during the biosynthesis of gentamicins. The 6'-pro-R-hydrogen atom of GenX2 is stereoselectively abstracted by the 5'-deoxyadenosyl radical and methylation occurs with retention of configuration at C6'. The regeneration of cob(I)alamin from cob(III)alamin is carried out with an as yet unidentified electron donor. " +"2.3.1.312","The enzyme, present in bacteria and archaea, participates in a pathway for the degradation of D-glutamate. The enzyme from the marine bacterium Pseudoalteromonas sp. CF6-2 can also acetylate D-glutamine, D-aspartate, and D-asparagine with lower activity." +"2.3.1.313","The enzyme, a member of the sirtuin family, removes the lipoyl group from the dihydrolipoamide acyltransferase (E2) component of 2-oxo acid dehydrogenase complexes such as EC 1.2.1.104, pyruvate dehydrogenase system. The enzyme often has additional activities and can remove other modifications of lysine residues such as acetyl and biotinyl groups. cf. EC 3.5.1.138, lipoamidase." +"2.3.2.37","The enzyme, detected in fungal species that belong to the Ascomycota and Basidiomycota phyla and characterized from Aspergillus fumigatus, is bifunctional. The AspRS domain catalyses the transfer of L-aspartate to tRNAAsp (EC 6.1.1.12), while the second domain carries out the transfer of L-aspartate to the 3beta-hydroxyl of ergosterol." +"2.4.1.393","The enzyme, present in mycobacterial species that produce a 3-O-methylmannose polysaccharide (MMP), is involved in recycling and biosynthesis of the polymer. The enzyme has the highest activity with 3-O-methylated mannosides with 4-6 residues. The residue at the reducing end of the substrate is often dimethylated, with the second methyl group attached at the O-1 position." +"2.4.99.26","This Gram-negative bacterial enzyme attaches the polymerized O antigen molecule to the outer core region of the lipid A-core oligosaccharide, finalizing the biosynthesis of the lipopolysaccharide. Prior to the reaction the two substrates are attached to the periplasmic-facing side of the inner membrane, and the enzyme transfers the O-antigen from its polyprenyl diphosphate membrane anchor (usually ditrans,octacis-undecaprenyl diphosphate) to a terminal sugar of the lipid A-core oligosaccharide. Despite the popular name ""ligase"", the enzyme is not a real ligase, as the reaction does not involve the hydrolysis of a phosphate bond in a triphosphate. The enzyme is embedded in the inner membrane and often has 12 trans-membrane segments. It is a metal-independent inverting glycosyltransferase, and in some cases it can attach surface polymers other than O-antigens to the lipid A-core oligosaccharide." +"2.4.99.27","The Wzy-type polymerase polymerizes O antigen repeat unit oligosaccharides that are anchored to the periplasmic face of the inner membrane, forming an O antigen polysaccharide that is still anchored to the membrane. A Wzz chain length regulator (sometimes referred to as an O-antigen co-polymerase) normally interacts with Wzy to confer a distinctive modal chain length distribution. The resultant polysaccharide is transferred from the membrane anchor to the lipid A-core oligosaccharide by EC 2.4.99.26, O-antigen ligase, forming a complete lipopolysaccharide structure. There is an enormous diversity of O antigen polymerases with different specificities, reflecting the variability in the structure and composition of O-antigens." +"2.5.1.157","The enzyme, found in all eukaryotes and some archaea, catalyses the final step in production of the modified rRNA nucleotide N1-methyl-N3-[(3S)-aminocarboxypropyl]-pseudouridine (m1acp3psi). This modified nucleotide is present in the small subunit of ribosomal RNA (18S in eukaryotes and 16S in archaea). cf. EC 2.5.1.114, tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase, and EC 2.5.1.108, 2-(3-amino-3-carboxypropyl)histidine synthase." +"2.7.11.35","Requires Mg2+. Peptide array data show a preference for phosphorylation of Thr over Ser and a preference for basic residues in the -5 to -1 positions [1]. CRIK is an animal-specific protein kinase that phosphorylates myosin light chain (cf. EC 2.7.11.18, myosin-light-chain kinase) and is involved in cytokinesis in both mammals and Drosophila. Human CRIK phosphorylates myosin light chain, MYL9/MRLC1 on T19/S20 [2] and GLI2 on S149 [3]. Drosophila CRIK (sticky) interacts with the kinesins Nebbish and Pavarotti, and human CRIK interacts with their orthologs, KIF14 and KIF23/MKLP1 to promote midbody formation during cytokinesis [4]. In Drosophila, CRIK/Sticky catalytic activity was required for this function. Human CRIK is mostly highly expressed in brain, and mutations that alter splicing or kinase activity lead to microcephaly [5, 6], as do knockouts in mouse and rat, and mutations in its interacting partner, the kinesin KIF14 [6]. " +"3.1.1.121","The enzyme has been detected in fungal species that belong to the Ascomycota and Basidiomycota phyla, and has been characterized from the fungus Aspergillus fumigatus." +"3.4.11.27","The enzyme from the archaeon Pyrococcus horikoshii OT3 is thermostable. In that enzyme Cys100 is the nucleophile responsible for the proteolytic activity, while Tyr120 regulates the catalytic conformation of Cys100 through a hydrogen bond, thereby affecting enzyme activity. The activity with L-Arginine is 90-300 times higher than with other N-terminal amino acids. The enzyme shows low endopeptidase activity." +"3.5.1.138","The enzyme, characterized from the bacterium Enterococcus faecalis, is a member of the Ser-Ser-Lys triad amidohydrolase family. cf. EC 2.3.1.313, NAD-dependent lipoamidase." +"4.1.2.64","The enzyme, characterized from the bacteria Veillonella ratti and Campylobacter jejuni, participates in an L-fucose degradation pathway. It also has significant activity with 2-dehydro-3-deoxy-D-pentonate (cf. EC 4.1.2.28, 2-dehydro-3-deoxy-D-pentonate aldolase)." +"4.1.99.28","Requires Mg2+. This enzyme, isolated from the bacterium Microbacterium 5-2b, participates in a carminate degradation pathway. Following the activity of EC 1.1.3.50, C-glycoside oxidase, it cleaves the C---C bond in 3'-dehydrocarminate. The sugar moiety is released lacking a hydroxyl at position 1, and containing a double bond between C-1 and C-2. The enzyme shows weak activity with other 3'-dehydro-C-glucosides." +"4.2.99.25","The enzyme, found in bacteria and archaea, is involved in the degradation of polysaccharides such as alginate and pectin. The enzyme catalyses a pyranose ring-opening reaction followed by enol-keto tautomerization." +"4.3.1.33","A pyridoxal 5'-phosphate enzyme. This bacterial enzyme, characterized from the marine bacterium Vibrio splendidus, expands the substrate scope of a widespread pathway for the degradation of 2-aminoethylphosphonate. The enzyme is highly specific and does not act on the S enantiomer of 1-hydroxy-2-aminoethylphosphonate or other structurally related compounds." +"5.1.1.25","The enzyme, present in bacteria and archaea, participates in a pathway for the degradation of D-glutamate." +"7.5.2.14","Unlike heteropolymeric O antigens, which are polymerized in the periplasm by EC 2.4.99.27, O-antigen polymerase Wzy, homopolymeric O antigens are polymerized inside the cytoplasm by a progressive transfer of sugar monomers to a growing chain attached to a polyprenyl diphosphate membrane anchor. When the chain reaches its full length it is transported across the cytoplasmic membrane by this ABC-type transporter, which consists of an ATP-binding subunit (Wzt) and an integral membrane protein (Wzm). Wzm proteins are poorly conserved in their primary sequence. Once in the periplasm, the O antigen is ligated to the lipid A-core complex by EC 2.4.99.26, O-antigen ligase." +"1.3.1.126","The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 2.1.1.391, demethylgadusol O-methyltransferase." +"1.8.1.22","Contains siroheme. The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. The system comprises the DsrAB reductase and the DsrL protein, which form a tight complex. The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. In sulfite reducers the DsrL component transfers two electrons from NADH to the DsrAB component, which then reduces the sulfur in sulfite to an S(II) intermediate that forms (together with two cysteine residues of DsrC) a trisulfide. In sulfur oxidizers the enzyme catalyses the opposite reaction [1]." +"1.8.5.10","This enzyme complex is present in both sulfate-reducing bacteria and sulfur-oxidizing bacteria, and acts in opposite directions during the reductive and oxidative pathways, respectively. DsrM and DsrP contain b-type hemes, DsrJ contains c-type hemes, DsrO is a ferredoxin-like protein, and DsrK is the catalytic subunit that acts as a disulfide reductase on DsrC proteins that contain a trisulfide bridge [1,3,4]. The complex receives the electrons from the membrane quinone pool [2,3]." +"2.1.1.391","The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 1.3.1.126, 2-epi-5-epi-valiolone dehydrogenase." +"2.3.3.22","This family of enzymes participates in a process that introduces a methyl branch into nascent polyketide products. The process begins with EC 4.1.1.124, malonyl-[acp] decarboxylase, which converts the common extender unit malonyl-[acp] to acetyl-[acp]. The enzyme is a mutated form of a ketosynthase enzyme, in which a Cys residue in the active site is modified to a Ser residue, leaving the decarboxylase function intact, but nulifying the ability of the enzyme to form a carbon-carbon bond. Next, EC 2.3.3.22, 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase, utilizes the acetyl group to introduce the branch at the beta position of 3-oxoacyl intermediates attached to a polyketide synthase, forming a 3-hydroxy-3-carboxymethyl intermediate. This is followed by dehydration catalysed by EC 4.2.1.181, 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase (often referred to as an ECH1 domain), leaving a 3-carboxymethyl group and forming a double bond between the alpha and beta carbons. The process concludes with decarboxylation catalysed by EC 4.1.1.125, 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase (often referred to as an ECH2 domain), leaving a methyl branch at the beta carbon. The enzymes are usually encoded by a cluster of genes referred to as an ""HMGS cassette"", based on the similarity of the key enzyme to EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase. While the enzyme is similar to EC 2.3.3.10, it is specific for an [acyl-carrier protein] (acp)-bound donor and does not interact with a CoA substrate as donor." +"2.4.1.395","The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage of the transferred glucosyl residue. The enzyme, characterized from the lactic acid bacterium Limosilactobacillus reuteri strain 121, catalyses the hydrolysis of sucrose and the transfer of the D-glucose moiety to suitable acceptors (inclduing sucrose), forming the glucan reuteran, which is typical for these strains. The enzyme forms mostly alpha(1->4) glucosidic linkages, but also alpha(1->6) linkages. The presence of maltose significantly accelerate the initial rate of the reaction. See EC 2.4.1.5, dextransucrase." +"2.4.1.396","The enzyme, discovered in several bacterial species, is similar to EC 2.4.1.395, reuteransucrase, yet is not able to act on sucrose. The enzyme, which belongs to the glycoside hydrolase 70 (GH70) family, possesses both hydrolase and transglycosylase activities, cleaving endo alpha(1->4) linkages from the non-reducing end of maltooligosaccharides and adding the resulting oligosaccharides to the non-reducing end of alpha-D-glucan chains that terminate with a residue linked by an alpha-(1->4) linkage, forming an alpha(1->6) linkage. The enzyme is not able to form successive alpha(1->6) linkages. Unlike EC 2.4.1.394, 4,6-alpha-glucanotransferase (linear substrates/linear products), which can only act on linear substrates, this enzyme is able to act on both linear and branched substrates, and can form the branched reuteran type of alpha-glucan." +"2.4.99.28","The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here). Involved in the synthesis of cell-wall peptidoglycan." +"3.1.1.122","The enzyme, which is inducible in the soil bacterium Nocardioides sp. (strain SG-4G), catalyses the degradation of the fungicide carbendazim. Following hydrolysis of the carbamate ester, the carbamate decarboxylates spontaneously." +"3.2.1.221","The enzyme, present in mycobacterial species that produce 3-O-methylmannose polysaccharide (MMP), is involved in recycling and biosynthesis of the polymer. The enzyme has been shown to cleave substrates in the range of 11--14 mannose residues." +"3.2.1.222","The enzyme is an endo hydrolase that hydrolyses the beta(1->4) bond in funoran, a polysaccharide produced by red algae of the genus Gloiopeltis. The enzyme from the marine bacterium Wenyingzhuangia aestuarii OF219 acts on agarose with a higher efficiency (cf. EC 3.2.1.81, beta-agarase), but binds funoran preferentially." +"3.2.1.223","The enzyme, characterized from the bacterium Bifidobacterium pseudocatenulatum, specifically hydrolyses beta-L-Arap-(1->3)-L-Araf disaccharides from the non-reducing terminal of arabinogalactan using an exo mode of action. It is active with arabinogalactan-proteins (AGPs) containing type II arabinogalactans such as gum arabic AGP and larch AGP. The enzyme can also hydrolyse alpha-D-Galp-(1->3)-L-Araf disaccharides (cf. EC 3.2.1.215) with a much lower activity." +"3.4.21.123",This bacterial pepstatin-insensitive carboxyl proteinase has been isolated and characterized from Bacillus sp. MN-32 and from several Burkholderia spp. Kumamolysin from Bacillus sp. MN-32 exhibits a Ser278/Glu78/Asp82 catalytic triad. The enzyme is a type example of peptidase family S53 in the MEROPS Peptidase Database. +"3.4.26.1","The cleavage site motif is typically referred to as CaaX, where the letter a represents any amino acid, rather than alanine, and X represents the C-terminal amino acid of the target protein. The enzyme has been found in the yeast Saccharomyces cerevisiae and homologues exist in humans and several other species. Although the cleavage site is similar to that of the metallo-peptidase Ste24 endopeptidase (EC 3.4.24.84), there appear to be specificity differences in the proteins hydrolysed by these two enzymes, with amino-acid substitution studies indicating activity of the yeast enzyme towards substrates with a hydrophylic residue at (P1') that are not hydrolysed by EC 3.4.24.84 [4]." +"3.4.26.2","The enzyme, isolated from the fungus Scytalidium lignicola and found in several other fungi, has a low pH optimum, being most active at pH 2 with casein as substrate. It differs from the pepsins (EC 3.4.23.1 and EC 3.4.23.2) in being insensitive to inhibition by pepstatin. It also differs from mammalian pepsins in showing a preference for a positively charged residue (Lys or Arg) at the P3 position. In addition to the catalytic Glu residue, a Gln residue appears to play an important role in the hydrolytic mechanism. A member of peptidase family G01, the ""eqolisin"" family of glutamic peptidases (G01.0001)." +"3.8.2.2",Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase. +"4.1.1.124","This family of enzymes participates in a process that introduces a methyl branch into nascent polyketide products. The process begins with EC 4.1.1.124, malonyl-[acp] decarboxylase, which converts the common extender unit malonyl-[acp] to acetyl-[acp]. The enzyme is a mutated form of a ketosynthase enzyme, in which a Cys residue in the active site is modified to a Ser residue, leaving the decarboxylase function intact, but nulifying the ability of the enzyme to form a carbon-carbon bond. Next, EC 2.3.3.22, 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase, utilizes the acetyl group to introduce the branch at the beta position of 3-oxoacyl intermediates attached to a polyketide synthase, forming a 3-hydroxy-3-carboxymethyl intermediate. This is followed by dehydration catalysed by EC 4.2.1.181, 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase (often referred to as an ECH1 domain), leaving a 3-carboxymethyl group and forming a double bond between the alpha and beta carbons. The process concludes with decarboxylation catalysed by EC 4.1.1.125, 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase (often referred to as an ECH2 domain), leaving a methyl branch at the beta carbon. The enzymes are usually encoded by a cluster of genes referred to as an ""HMGS cassette"", based on the similarity of the key enzyme to EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase. cf. EC 4.1.1.87, malonyl-[malonate decarboxylase] decarboxylase." +"4.1.1.125","This family of enzymes participates in a process that introduces a methyl branch into nascent polyketide products. The process begins with EC 4.1.1.124, malonyl-[acp] decarboxylase, which converts the common extender unit malonyl-[acp] to acetyl-[acp]. The enzyme is a mutated form of a ketosynthase enzyme, in which a Cys residue in the active site is modified to a Ser residue, leaving the decarboxylase function intact, but nulifying the ability of the enzyme to form a carbon-carbon bond. Next, EC 2.3.3.22, 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase, utilizes the acetyl group to introduce the branch at the beta position of 3-oxoacyl intermediates attached to a polyketide synthase, forming a 3-hydroxy-3-carboxymethyl intermediate. This is followed by dehydration catalysed by EC 4.2.1.181, 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase (often referred to as an ECH1 domain), leaving a 3-carboxymethyl group and forming a double bond between the alpha and beta carbons. The process concludes with decarboxylation catalysed by EC 4.1.1.125, 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase (often referred to as an ECH2 domain), leaving a methyl branch at the beta carbon. The enzymes are usually encoded by a cluster of genes referred to as an ""HMGS cassette"", based on the similarity of the key enzyme to EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase." +"4.1.1.126","The enzyme catalyses a step in the archaeal prenyl diphosphate biosynthesis pathway. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase." +"4.2.1.181","This family of enzymes participates in a process that introduces a methyl branch into nascent polyketide products. The process begins with EC 4.1.1.124, malonyl-[acp] decarboxylase, which converts the common extender unit malonyl-[acp] to acetyl-[acp]. The enzyme is a mutated form of a ketosynthase enzyme, in which a Cys residue in the active site is modified to a Ser residue, leaving the decarboxylase function intact, but nulifying the ability of the enzyme to form a carbon-carbon bond. Next, EC 2.3.3.22, 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase, utilizes the acetyl group to introduce the branch at the beta position of 3-oxoacyl intermediates attached to a polyketide synthase, forming a 3-hydroxy-3-carboxymethyl intermediate. This is followed by dehydration catalysed by EC 4.2.1.181, 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase (often referred to as an ECH1 domain), leaving a 3-carboxymethyl group and forming a double bond between the alpha and beta carbons. The process concludes with decarboxylation catalysed by EC 4.1.1.125, 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase (often referred to as an ECH2 domain), leaving a methyl branch at the beta carbon. The enzymes are usually encoded by a cluster of genes referred to as an ""HMGS cassette"", based on the similarity of the key enzyme to EC 2.3.3.10, hydroxymethylglutaryl-CoA synthase. cf. EC 4.2.1.18, methylglutaconyl-CoA hydratase." +"4.2.1.182","The enzyme catalyses a step in an archaeal prenyl diphosphate biosynthesis pathway. It belongs to the aconitase X family, and contains a [4Fe-4S] cluster." +"4.2.2.29","A group of bacterial enzymes that catalyse the non-hydrolytic cleavage of peptidoglycan (PG). The enzymes fragment the polysaccharide chain at the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues by an intramolecular cyclization of the N-acetylmuramyl moiety to yield a 1,6-anhydro-N-acetyl-beta-D-muramyl product. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. The MtlG enzyme of Gram-negative bacteria may function to regulate glycan strand length within the PG polymer." +"4.2.3.212","The enzyme is involved in the biosynthesis of sesquiterpenoids from (2E,6E)-farnesyl diphosphate in fungi such as Boreostereum vibrans and Coniophora puteana." +"4.2.3.213","Isolated from Colletotrichum gloeosporioides, a pathogenic fungus that causes bitter rot in variety of crops." +"4.2.3.214","Isolated from Colletotrichum gloeosporioides, a pathogenic fungus that causes bitter rot in variety of crops." +"4.2.3.215","Isolated from the fungus Colletotrichum gloeosporioidea. delta-Araneosene may be involved in the biosynthesis of dolasta-1(15),8-diene (see EC 4.2.3.214, dolasta-1(15),8-diene synthase) and cycloaraneosene (see EC 4.2.3.191, cycloaraneosene synthase)." +"4.2.3.216","A sesterterpenoid synthase enzyme isolated from the bacterium Streptomyces somaliensis. The enzyme also produces somalensene B (cf. EC 4.2.3.217, somaliensene B synthase)." +"4.2.3.217","A sesterterpenoid synthase enzyme isolated from the bacterium Streptomyces somaliensis. The enzyme also produces somaliensene A (cf. EC 4.2.3.216, somaliensene A synthase)." +"4.2.3.218",A diterpenoid synthase enzyme isolated from the fungus Aspergillus stellatus. +"4.2.3.219",A sesterterpenoid synthase enzyme isolated from the fungus Aspergillus stellatus. +"6.7.1.2","The enzyme, characterized from the bacterium Streptomyces sp. RI-77, participates in the biosynthesis of avenalumate, a phenolic acid originally described from oat (Avena sativa). It can also act on 3-aminocoumarate and 3-amino-4-hydroxybenzoate with lower activity." +"1.1.1.438","The enzyme from Corynebacterium cyclohexanicum is highly specific for the cis-4-hydroxy derivative. cf. EC 1.1.1.226, trans-4-hydroxycyclohexanecarboxylate dehydrogenase." +"1.5.1.55","The enzyme, characterized from the cyanobacterium Synechocystis sp. PCC 6803, catalyses the reductive condensation of agmatine and L-aspartate 4-semialdehyde. It participates in a biosynthetic pathway for spermidine." +"1.14.13.252","Contains FAD. The enzyme, characterized from multiple bacterial species, participates in the biosynthesis of assorted siderophores." +"1.14.14.185",The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew). +"1.17.3.5","Contains FAD. The enzyme, characterized from the bacterium Corynebacterium cyclohexanicum, participates in a cyclohexane-1-carboxylate degradation pathway." +"2.3.1.314","The enzyme is found in plant chloroplasts and cyanobacteria. The plant enzyme can also employ acyl carrier proteins and galactolipids as acyl donors, while the enzyme from the cyanobacterium Synechocystis sp. PCC 6803 only uses acyl-CoAs. The enzyme also catalyses the activity of EC 2.3.1.20, diacylglycerol O-acyltransferase." +"2.3.1.315","The enzyme, characterized from the bacterium Geobacter metallireducens, participates in an anaerobic degradation pathway for cyclohexane-1-carboxylate. In vitro, the enzyme can use butanoyl-coA as a CoA donor with greater efficiency than succinyl-CoA." +"2.3.1.316","The enzyme, characterized from the bacterium Acinetobacter baumannii ATCC 17978, participates in the biosynthesis of fimsbactin siderophores." +"2.4.1.397","This enzyme is the cyclization domain of cyclic beta-1,2-glucan synthase. Enzymes from Brucella abortus and Thermoanaerobacter italicus were characterized. The cyclization domain of cyclic beta-1,2-glucan synthase is flanked by an N-terminal beta-1,2-glucosyltransferase domain (a UDP-alpha-D-glucose-dependent synthase, not EC 2.4.1.391) and a C-terminal beta-1,2-glucoside phosphorylase domain (cf. EC 2.4.1.333), with the former responsible for elongation and the latter for chain length control. The cyclization domain of Thermoanaerobacter italicus cyclizes linear oligosaccharides with a degree of polymerization (DP) of 21 or higher to produce cyclic glucans with DP 17 or higher. The cyclization domain also disproportionates linear beta-1,2-glucooligosaccharides without cycling. The entire cyclic beta-1,2-glucan synthase from Brucella abortus synthesizes cyclic beta-1,2-glucans with DP 17-22." +"2.5.1.158","This activity has been characterized from a number of fungal bifunctional enzymes. Following the formation of hexaprenyl diphosphate, a different domain in the enzymes catalyses its cyclization into a triterpene (see EC 4.2.3.221, macrophomene synthase and EC 4.2.3.220, talaropentaene synthase). cf. EC 2.5.1.82, hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]." +"2.5.1.159","Requires Mg2+. The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, is involved in the biosynthesis of hapalindole-type alkaloids. " +"2.6.1.125","Requires pyridoxal 5'-phosphate. The enzyme, characterized from several bacterial species, is known to participate in L-arginine degradation and in the biosynthesis of the rare amino acid (3R)-3-methyl-L-arginine. The enzyme from Streptomyces arginensis also catalyses the activity of EC 2.6.1.126, L-aspartate:5-guanidino-3-methyl-2-oxopentanoate transaminase." +"2.6.1.126","Requires pyridoxal 5'-phosphate. The enzyme, characterized from several bacterial species, participates in the biosynthesis of the rare amino acid (3R)-3-methyl-L-arginine. The enzyme from Streptomyces arginensis also catalyses the activity of EC 2.6.1.125, L-arginine:2-oxoglutarate transaminase." +"2.7.11.36","Requires Mg2+. Peptide array data suggest that MASTL prefers to phosphorylate Ser over Thr, followed at position +1 by a bulky hydrophobic (Met, Leu, Phe or Tyr) and with an aromatic residue in the -2 position [4]. Its main role in animal systems is in the regulation of mitosis by phosphorylating a conserved site on endosulfine family proteins (ENSA and ARPP-19 in human), causing them to inhibit the protein phosphatase 2A-B55 [protein phosphatase 2A (PP2A) holoenzyme complex containing a B55-family regulatory subunit] [2]." +"2.7.11.37","Requires Mg2+. MAST (Microtubule Associated Serine/Threonine) kinases are eukaryotic-wide kinases with roles in microtubule function, PTEN regulation and a variety of neuronal functions. They are found in most eukaryotes, though lost from most fungi and ciliates. MAST kinases associate with their substrates via their PDZ domains. Substrates include the PTEN phosphatase (EC 3.1.3.67) in human and nematodes, and Dlic (Dynein light intermediate chain) in Drosophila. The latter is phosphorylated on Ser401." +"3.1.2.33","The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in an L-carnitine degradation pathway." +"3.1.3.110",The enzyme has been characterized from mammals and from the bacterium Streptantibioticus cattleyicolor. In mammals it hydrolyses excess 4'-phosphopantetheine to prevent cell damage. In S. cattleyicolor it participates in the biosynthesis of the beta-lactam antibiotic thienamycin. +"3.2.1.224","The enzyme, characterized from the bacterium Microbacterium arabinogalactanolyticum, hydrolyses beta-D-arabinofuranosides from the non-reducing terminal of D-arabinan core structure of lipoarabinomannan and arabinogalactan of mycobacterial cell wall. cf. EC 3.2.1.55, non-reducing end alpha-L-arabinofuranosidase; EC 3.2.1.185, non-reducing end beta-L-arabinofuranosidase; EC 3.2.1.225, D-arabinan exo alpha-(1,3)/(1,5)-arabinofuranosidase (non-reducing end); and EC 3.2.1.226, D-arabinan endo alpha-(1,5)-arabinofuranosidase." +"3.2.1.225","The enzyme hydrolyses alpha-D-arabinofuranosides with (1->3)- and (1->5)-linkages in D-arabinan core structure of lipoarabinomannan and arabinogalactan of mycobacterial cell wall. cf. EC 3.2.1.55, non-reducing end alpha-L-arabinofuranosidase; EC 3.2.1.224, D-arabinan exo beta-(1,2)-arabinofuranosidase (non-reducing end); and EC 3.2.1.226, D-arabinan endo alpha-(1,5)-arabinofuranosidase." +"3.2.1.226","The enzyme hydrolyses alpha-(1->5)-D-arabinofuranoside bonds in D-arabinan core structure of lipoarabinomannan and arabinogalactan of mycobacterial cell wall. cf. EC 3.2.1.224, D-arabinan exo beta-(1,2)-arabinofuranosidase (non-reducing end) and EC 3.2.1.225, D-arabinan exo alpha-(1,3)/(1,5)-arabinofuranosidase (non-reducing end)." +"3.5.3.27","The enzyme, characterized from different cyanobacterial species, is highly specific to arginine and does not require a metal cofactor. The enzyme from Nostoc is bifunctional, and also catalyses the activity of EC 4.3.1.12, ornithine cyclodeaminase." +"3.5.99.12","The enzyme, present in mammalian brains, forms the catechol isoquinoline (R)-salsolinol. This compound can be metabolized to (R)-N-methylsalsolinol, a 1-methyl-4-phenylpyridinium-like neurotoxin that impairs the function of dopaminergic neurons, causing the clinical symptoms of Parkinson's disease." +"3.5.99.13","Catalyses a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine [4,5]. Involved in the biosynthesis of the monoterpenoid indole alkaloids." +"3.5.99.14","The reaction makes a six-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates. The product is the precursor of the benzylisoquinoline alkaloids in plants. The enzyme, formerly known as (S)-norlaudanosoline synthase, will also catalyse the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants." +"3.5.99.15","The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 3.5.99.16, deacetylipecoside synthase. The product is rapidly converted to demethylisoalangiside." +"3.5.99.16","The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 3.5.99.15, deacetylisoipecoside synthase. The product is rapidly converted to demethylalangiside." +"3.6.1.77","The enzyme belongs to the Nudix hydrolase family. It has been reported from bacteria, yeast, and mammals. Activity is higher with oxidized disulfide CoA than with reduced CoA." +"4.1.1.127","A pyridoxal 5'-phosphate protein. The enzyme, characterized from the cyanobacterium Synechocystis sp. PCC 6803, participates in a biosynthetic pathway for spermidine." +"4.1.2.65",The enzyme is located in the chloroplasts of vanilla pods of the orchid Vanilla planifolia. It also converts ferulic acid 4-O-beta-D-glucopyranoside to vanillin 4-O-beta-D-glucopyranoside. +"4.1.2.66","The enzyme has been purified from vanilla pods of the orchid Vanilla planifolia. It is highly specific for 4-coumarate. Similar compounds such as cinnamate, caffeate, sinapate and o-coumarate are not substrates." +"4.1.99.29","The enzyme participates in alternative menaquinone biosynthesis pathways known as the futalosine and modified futalosine pathways, which occurs in some bacterial species including several human pathogens such as Helicobacter pylori, Campylobacter jejuni, and Chlamydia." +"4.2.1.183","A heme-thiolate protein (P-450) occurring in several plants, including Allium sativum (garlic) and Selaginella moellendorffii (spikemoss). The enzyme also catalyses the reaction of EC 4.2.1.121, colneleate synthase, to a lesser extent." +"4.2.3.220",Isolated from the fungus Talaromyces verruculosus. +"4.2.3.221","Isolated from Macrophomina phaseolina, a pathogenic fungus that causes damping off, seedling blight, collar rot, stem rot, charcoal rot, basal stem rot, and root rot on many plant species. The 22-membered ring in macrophomene represents the largest macrocycle discovered in terpenes so far." +"4.2.3.222","A diterpene synthase from the fungus Diaporthe amygdali. Phomopsene synthase has also been isolated from the bacteria Nocardia testacea, Nocardia rhamnosiphila and Allokutzneria albata. The Allokutzneria albata enzyme also generates allokutznerene (EC 4.2.3.224, allokutznerene synthase) and traces of (-)-spiroviolene (EC 4.2.3.158, (-)-spiroviolene synthase)." +"4.2.3.223",A diterpene synthase isolated from the bacterium Allokutzneria albata. +"4.2.3.224","A diterpene synthase isolated from the bacterium Allokutzneria albata. It also produces phomopsene (EC 4.2.3.222, phomopsene synthase) and traces of (-)-spiroviolene (EC 4.2.3.158, (-)-spiroviolene synthase). " +"4.2.3.225",A diterpene synthase isolated from the bacterium Streptantibioticus cattleyicolor. +"4.2.3.226","The enzyme occurs in plants. The initial cyclization product is a (7R)-beta-bisabolyl cation. The major final product is (+)-2-epi-prezizaene. Other products are (-)-alpha-cedrene (cf. EC 4.2.3.227, (-)-alpha-cedrene synthase), small amounts of (-)-beta-curcumene, and other sesquiterpenes with less than 10% yield. The enzyme also catalyses the reaction of EC 4.2.3.61, 5-epiaristolochene synthase." +"4.2.3.227","The enzyme occurs in plants. The initial cyclization product is a (7R)-beta-bisabolyl cation. (-)-alpha-Cedrene is one of the major products. Other products are (+)-2-epi-prezizaene (cf. EC 4.2.3.226, (+)-2-epi-prezizaene synthase), small amounts of (+)-beta-curcumene, and other sesquiterpenes with less than 10% yield. The enzyme from Nicotiana tabacum (tobacco) also catalyses the reaction of EC 4.2.3.61, 5-epiaristolochene synthase." +"4.2.3.228","The enzyme occurs in flowers (pistillate inflorescences) of Cannabis sativa. The enzyme encoded by CsTPS13PK produces 94% (Z)-beta-ocimene from geranyl diphosphate. cf. EC 4.2.3.106, (E)-beta-ocimene synthase." +"4.2.3.229",The enzyme has been shown to occur in castor bean (Ricinus communis) and rice (Oryza sativa). ent-Beyerene is also a product of EC 4.2.3.19 (ent-kaurene synthase) of the moss Physcomitrella patens. +"5.5.1.36","Requires Ca2+. The enzyme, which belongs to the Stig cyclases, has been characterized from multiple species of the cyanobacterial genera Fischerella and Westiellopsis. Stig cyclases catalyse a three step process including a Cope rearrangement, 6-exo-trig cyclization and electrophilic aromatic substitution. The enzyme is a heterodimer of two different proteins (AmbU1 and AmbU4). On their own, AmbU1 catalyses a different reaction, producing 12-epi-hapalindole U (cf. EC 5.5.1.32, 12-epi-hapalindole U synthase) while AmbU4 appears to be inactive. Formation of hapalindole U leads to the biosynthesis of additional terpenoid indole alkaloids such as hapalindole G, ambiguine H, and ambiguine A." +"5.6.2.5","RNA helicases, which participate in nearly all aspects of RNA metabolism, utilize the energy from ATP hydrolysis to unwind RNA. The engine core of helicases is usually made of a pair of RecA-like domains that form an NTP binding cleft at their interface. Changes in the chemical state of the NTP binding cleft (binding of the NTP or its hydrolysis products) alter the relative positions of the RecA-like domains and nucleic acid-binding domains, creating structural motions that disrupt the pairing of the nucleic acid, causing separation and unwinding. Most RNA helicases utilize a mechanism known as canonical duplex unwinding, in which the helicase binds to a single stranded region adjacent to the duplex and then translocates along the bound strand with defined directionality, displacing the complementary strand. Most of these helicases proceed 3' to 5' (type A polarity - cf. EC 5.6.2.6, RNA 3'-5' helicase), but some proceed 5' to 3' (type B polarity), and some are able to catalyse unwinding in either direction [1,4]. Most canonically operating helicases require substrates with single stranded regions in a defined orientation (polarity) with respect to the duplex. A different class of RNA helicases, EC 5.6.2.7, DEAD-box RNA helicase, use a different mechanism and unwind short stretches of RNA with no translocation." +"5.6.2.6","RNA helicases, which participate in nearly all aspects of RNA metabolism, utilize the energy from ATP hydrolysis to unwind RNA. The engine core of helicases is usually made of a pair of RecA-like domains that form an NTP binding cleft at their interface. Changes in the chemical state of the NTP binding cleft (binding of the NTP or its hydrolysis products) alter the relative positions of the RecA-like domains and nucleic acid-binding domains, creating structural motions that disrupt the pairing of the nucleic acid, causing separation and unwinding. Most RNA helicases utilize a mechanism known as canonical duplex unwinding, in which the helicase binds to a single stranded region adjacent to the duplex and then translocates along the bound strand with defined directionality, displacing the complementary strand. Most of these helicases proceed 3' to 5' (type A polarity), but some proceed 5' to 3' (type B polarity - cf. EC 5.6.2.5, RNA 5'-3' helicase), and some are able to catalyse unwinding in either direction [1,3]. Most canonically operating helicases require substrates with single stranded regions in a defined orientation (polarity) with respect to the duplex. A different class of RNA helicases, EC 5.6.2.7, DEAD-box RNA helicase, use a different mechanism and unwind short stretches of RNA with no translocation." +"5.6.2.7","RNA helicases, which participate in nearly all aspects of RNA metabolism, utilize the energy from ATP hydrolysis to unwind RNA. The engine core of helicases is usually made of a pair of RecA-like domains that form an NTP binding cleft at their interface. Changes in the chemical state of the NTP binding cleft (binding of the NTP or its hydrolysis products) alter the relative positions of the RecA-like domains and nucleic acid-binding domains, creating structural motions that disrupt the pairing of the nucleic acid, causing separation and unwinding. While most RNA helicases utilize a mechanism known as canonical duplex unwinding and translocate along the RNA (cf. EC 5.6.2.5, RNA 5'-3' helicase and EC 5.6.2.6, RNA 3'-5' helicase), DEAD-box RNA helicases differ by unwinding RNA via the local strand separation mechanism, which does not involve translocation. These helicases load directly on the duplex region, aided by single stranded or structured nucleic acid regions. Upon loading, the DEAD-box protein locally opens the duplex strands. This step requires binding of ATP, which is not hydrolysed. The local helix opening causes the remaining basepairs to dissociate without further action from the enzyme. Unwinding occurs without apparent polarity, and is limited to relatively short distances. ATP hydrolysis is required for release of the DEAD-box protein from the RNA. The name originates from the sequence D-E-A-D, which is found in Motif II of these proteins." +"6.3.2.63","Requires Mg2+. The enzyme, characterized from the bacteria Shewanella spp. MR-4 and MR-7, catalyse the last step in the biosynthesis of the siderophore putrebactin. The enzyme catalyses the reaction in two steps - concatenation of two molecules of N1-hydroxy-N1-succinylputrescine, followed by cyclization." +"6.3.2.64","Requires Mg2+. The enzyme, characterized from the bacterium Aliivibrio salmonicida, catalyses the last step in the biosynthesis of the siderophore bisucaberin. The enzyme catalyses the reaction in two steps - concatenation of two molecules of N1-hydroxy-N1-succinylcadaverine, followed by cyclization." +"7.2.1.4","Involved in the formation of methane from CO2 in methanogenic archaea. The reaction involves the export of one or two sodium ions. The enzyme from the archaeon Methanobacterium thermoautotrophicum is a membrane-associated multienzyme complex composed of eight different subunits, and contains a 5'-hydroxybenzimidazolyl-cobamide cofactor, to which the methyl group is attached during the transfer. A soluble enzyme that is induced by the presence of CO has been reported as well [6]." +"1.1.1.439","The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs." +"1.1.1.440",Isolated from the plant Alstonia scholaris (blackboard tree). +"1.3.1.127",The enzyme has been charachterized from the plant Rauvolfia serpentina. +"1.3.1.128","The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs. The enzyme forms the iminium ion form of dihydroprecondylocarpine acetate, which spontaneously rearranges and undergoes deacylation, producing dehydrosecodine." +"1.5.1.56","The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs. Both the substrate and the product of the enzyme are unstable." +"1.5.3.27","Contaions FAD. The enzyme also acts, with lower efficiency, on 2-aminoethylphosphonate, generating phosphonoacetaldehyde and ammonia. The enzyme from Acinetobacter baumannii also transformed 2-(dimethylaminoethyl)phosphonate with appreciable efficiency, generating dimethylamine in place of methylamine." +"1.13.11.94",The enzyme was isolated from the bacterium Caulobacter segnis and the fungus Thermothelomyces thermophilus. It is used as an economic option in lignin degradation since it does not require a cofactor. +"1.14.14.186",A cytochrome P-450. The enzyme has been characterized from rice (Oryza sativa) and walnut (Juglans regia). +"1.14.14.187",A heme-thiolate protein (P-450) isolated from the plant Alstonia scholaris (blackboard tree). +"1.14.15.40","The enzyme, characterized from the bacterium Corynebacterium cyclohexanicum, is a cytochrome P-450 enzyme that participates in the degradation pathway of cyclohexane-1-carboxylate. The initial source of the electrons is NADH, which transfers the electrons to a specific [2Fe-2S] ferredoxin via a dedicated EC 1.18.1.3, ferredoxin---NAD+ reductase." +"1.14.19.80","A cytochrome P-450 (heme-thiolate) enzyme characterized from the plant Catharanthus roseus (Madagascar periwinkle), that participates in the biosynthesis of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine. The enzyme generates a nine-carbon ring that contains a nitrogen atom. The direct product of the enzyme, 3,17-didehydrostemmadenine, is unstable, and in the absence of other enzymes becomes akuammicine non-enzymically. However, in the presence of two dehydrogenases it is converted to stemmadenine via 17-dehydrostemmadenine." +"1.14.19.81","A heme-thiolate protein (P-450). The enzyme, characterized from the plants Rauwolfia serpentina (Indian snakeroot) and Gelsemium sempervirens (yellow jessamine), is involved in the biosynthesis of monoterpenoid indole alkaloids of the sarpagan, ajmalan and alstophyllan classes." +"1.21.3.11","The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs. The enzyme is similar to berberine bridge enzymes such as EC 1.21.3.3, reticuline oxidase, and requires an FAD cofactor." +"1.97.1.13","An oxygen-sensitive enzyme that contains tungsten-molybdopterin and iron-sulfur clusters, isolated the hyperthermophilic archaeon Pyrococcus furiosus. In that organism the enzyme is heterodimeric, comprising a catalytic subunit that contains the active site tungsto-bispyranopterin cofactor and a [4Fe-4S] cluster and an electron-transfer subunit that contains four additional [4Fe-4S] clusters. The activity involves two steps: an oxidative desulfonation reaction, followed by the activation of a second water molecule and oxidation of the resulting aldehyde (cf. EC 1.2.7.5, aldehyde ferredoxin oxidoreductase)." +"1.97.1.14","The enzyme, characterized from the bacterium Mesobacillus selenatarsenatis, is a membrane anchored type I molybdoenzyme. The enzyme is a complex comprising three heterologous subunits that contains a guanylyl molybdenum cofactor and multiple iron-sulfur clusters. The enzyme receives electrons directly from the membrane quinol pool and reduces selenate to selenite." +"2.1.1.392","The enzyme, characterized from the plant Rauvolfia serpentina (Indian snakeroot), catalyses the last step in the pathway for the biosynthesis of the monoterpenoid indole alkaloid ajmaline. Also reacts with 4-methylnorajmaline." +"2.1.1.393","Isolated from the plant Rauvolfia serpentina (Indian snakeroot). The enzyme can also methylate norajmaline, with lower activity." +"2.1.1.394","A radical SAM (AdoMet) enzyme that catalyses two consecutive methylations during the biosynthesis of complex carbapenem antibiotics. The enzyme adds a methyl group at position 6, followed by a second methylation that converts the methyl group to an ethyl group. The enzyme binds a [4Fe-4S] cluster and requires a cobalamin cofactor and an electron donor. Methyl viologen can be used in vitro." +"2.1.1.395","This activity is the penultimate step in the bionsynthesis of the alkaloid emetine. It is catalysed by two enzymes isolated from the roots of the tropical plant Carapichea ipecacuanha, IpeOMT2 and CiOMT1. The latter also catalyses the activity of EC 2.1.1.396, cephaeline 6'-O-methyltransferase, but with much lower activity." +"2.1.1.396","The enzyme IpeOMT1, isolated from the roots of the tropical plant Carapichea ipecacuanha, catalyses the final step in the bionsynthesis of the alkaloid emetine. A second enzyme isolated from the same plant, CiOMT1, also catalyses this activity, but catalyses the activity of EC 2.1.1.395, 7'-O-demethylcephaeline methyltransferase, with a much higher activity." +"2.3.1.317","The enzyme, characterized from Pseudomonas aeruginosa and other bacteria, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). It participates in an L-carnitine degradation pathway. cf. EC 2.3.1.247, (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase, EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase." +"2.3.1.318","The enzyme, characterized from the bacteria Pseudomonas aeruginosa and Cupriavidus necator H16, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). cf. EC 2.3.1.247, (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase, EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, and EC 2.3.1.319, 3,5-dioxohexanoate:acetyl-CoA acetone transferase." +"2.3.1.319","The enzyme, characterized from fungus Blumeria graminis, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE). cf. EC 2.3.1.247, (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase, EC 2.3.1.317, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, and EC 2.3.1.318, 3-oxoadipate:acetyl-CoA acetyltransferase." +"2.3.1.320",The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew). +"2.3.1.321","The enzyme, present in Taxus species (yew) catalyses the final step in paclitaxel (Taxol) biosynthesis." +"2.3.1.322",Isolated from the plant Alstonia scholaris (blackboard tree). +"2.3.1.323","The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs." +"2.4.1.398","Requires Mn2+. The enzyme, characterized from the flilamentous fungi Aspergillus nidulans and Aspergillus fumigatus, participates in the synthesis of fungal-type galactomannan and O-mannose-type galactomannan, which are embedded in the fungal cell walls. While the reaction shown here describes the transfer of one galactofuransyl residue, the enzyme can add up to 5 more galactofuranosyl residues." +"2.5.1.160","A pyridoxal 5'-phosphate-dependent enzyme, found in plants, that participates in the plant L-methionine biosynthetic pathway. It differs from its bacterial counterpart, EC 2.5.1.48, cystathionine gamma-synthase, in being specific for O-phospho-L-homoserine (the bacterial enzyme is specific for O-succinyl-L-homoserine)." +"2.7.11.38","This enzyme is found in animals and choanoflagellates, although it has been lost in arthropods and nematodes. It is implicated in centrosome separation [1] and cilium formation [6]. In peptide arrays, the enzyme prefers to phosphorylate Ser, with acidic residues at -2 and -4/-5, similar to that of the NEK6 protein kinase subfamily [4]. NEK9 can autophosphorylate. Substrates in humans include the microtubule-associated protein kinases NEK6/7 [1], the microtubule-associated protein spindle assembly protein TPX2 [3], the gamma-tubulin associated protein NEDD1, which is required for mitotic spindle assembly and function [2] and the LC3B protein, which is involved in autophagy substrate selection and autophagosome biogenesis [5]." +"2.7.11.39","Requires Mg2+. An animal specific kinase that is duplicated in vertebrates (ROCK1, ROCK2), and with homologs in Drosophila (rok) and Caenorhabditis elegans (let-502). They are ~1300 amino-acid proteins, with an N-terminal kinase domain, with the AGC-specific kinase domain tail, followed by a central coiled-coil region, HR1 domain, Rho-binding domain (RBD), and PH domain. The PH domain is split by an inserted CRD (cysteine-rich Zn finger motif). ROCK is activated by the small GTPase Rho and modulates the cytoskeleton by phosphorylation of a wide array of other cytoskeletal proteins. Binding of Rho-GTP to the RBD relieves an intramolecular inhibition and activates the kinase activity. These kinases modulate the cytoskeleton in response to Rho GTPase signalling. Substrates include LIM-kinase (LIMK) which phosphorylates and inhibits cofilin, blocking its actin-depolymerizing function [1], and myosin regulatory light chain (MRLC2/MYL12B) that regulates Myosin II. In Drosophila it is involved in the planar cell polarity pathway, where it is genetically downstream of frizzled and dishevelled gene families, and phosphorylates the non-muscle myosin light chain, regulating Myosin II [2]. It is activated by Rho1, the single homolog of human RhoA/B/C, which also activate ROCK." +"3.1.3.111","The enzyme, studied from mycobacteria, in involved in the biosynthesis of trans,octacis-decaprenylphospho-beta-D-arabinofuranose, which serves in those organisms as the arabinofuranose donor for the biosynthesis of the cell wall polymers arabinogalactan and lipoarabinomannan." +"3.1.3.112","The enzyme can catalyse the sequential hydrolysis of tri-, di-, and mono-phosphorylated oxetanocin A compounds, releasing one molecule of inorganic phosphate at a time. The active site switches from a dinuclear to a mononuclear metal center as phosphates are eliminated from the substrate." +"3.1.4.62","This activity, which is similar to that of EC 3.1.4.3, phospholipase C, has been characterized from mammalian cells [1-4]. Multiple enzymes have been shown to catalyse this activity, including human sphingomyelin synthase-related protein (SMSr, gene name; SAMD8) [6-8] and sphingomyelin synthase 1 (SMS1, gene name; SGMS1) [9] (cf. EC 2.7.8.27, sphingomyelin synthase). Minor activity was also observed by sphingomyelin synthase 2 (SMS2, gene name; SGMS2) [10]." +"3.13.2.4","The lanthipeptides are a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) that is characterized by the presence of multiple lanthionine (Lan) and 3-methyllanthionine (MeLan) crosslinks, which are formed by lanthipeptide synthases. These enzymes catalyse dehydration of Ser/Thr residues, followed by intramolecular addition of the thiol group of a Cys residue to the dehydro amino acids, which results in the formation of the thioether crosslinks of (methyl)lanthionine." +"4.1.1.128","The enzyme has been described from pathogenic Bacillus species, including Bacillus anthracis, Bacillus thuringiensis, and Bacillus cereus. The enzyme requires an NAD cofactor, and the reaction proceeds via a 4-dehydro intermediate, resulting in reduction of NAD+ to NADH (cf. EC 1.1.1.305, UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)). However, NADH is not released from the enzyme and is recycled back to NAD+ at the completion of the reaction cycle. The product is incorporated into an extracellular polysaccharide known as pzX." +"4.1.1.129","The enzyme, characterized from the bacterium Chondromyces crocatus, catalyses the final reactions in the biosynthesis of the antibiotics chondrochloren A andchondrochloren B." +"4.3.3.9","The enzyme, found in a number of bacterial strains, is a non-ribosomal peptide synthase (NRPS). The enzyme forms 3-amino-1,5-dihydropyridine-2,6-dione, which undergoes spontaneous oxidation to form the blue pigment indigoidine." +"5.1.3.45","The enzyme is found in bacteria and participates in the biosynthesis of assorted bacterial lipopolysaccharides and capsular polysaccharides. It contains a tightly-bound NAD(H) cofactor. The enzyme also catalyses the activity of EC 5.1.3.7, UDP-N-acetylglucosamine 4-epimerase, with lower efficiency." +"5.3.99.13","The enzyme is a B12-dependent radical SAM (AdoMet) enzyme involved in the biosynthesis of oxetanocin A. The enzyme catalyses an oxidative ring contraction, forming an oxetane aldehyde. The reaction requires S-adenosyl-L-methionine, a cobalamin cofactor, and a reductant (the reductant does not show in the overall reaction because it is being restored during the cycle). The reaction is initiated by formation of 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen atom from C2'. The enzyme is also able to catalyse the radical mediated, stereoselective C2'-methylation of dAMP." +"5.5.1.37","The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), is a carboxylesterase-like cyclase that catalyses a regio- and enantiodivergent [4+2] cycloaddition reaction to generate the iboga scaffold of catharanthine. cf. EC 5.5.1.38, tabersonine synthase." +"5.5.1.38","The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), is a carboxylesterase-like cyclase that catalyses a regio- and enantiodivergent [4+2] cycloaddition reaction to generate the aspidosperma scaffold of tabersonine. cf. EC 5.5.1.37, catharanthine synthase." +"6.3.1.22","The enzyme, charactrized from the bacterium Bacillus subtilis, catalyses a similar tRNA modification to that performed by EC 2.3.1.193, tRNAMet cytidine acetyltransferase. However, unlike that enzyme, which uses acetyl-CoA as the acetyl donor, this enzyme activates an acetate ion to form acetyladenylate and then catalyses the acetylation through a mechanism similar to tRNA aminoacylation." +"1.1.1.441","The enzyme, present in all eukaryotes, catalyses the dehydrogenation of ditrans,polycis-polyprenol and the reduction of dolichal as part of the pathway that converts ditrans,polycis-polyprenol to dolichol (cf. 1.3.1.94, polyprenal reductase). The enzyme works equally well with NAD+ and NADP+, but due to the cellular ratios of NAD+/NADH and NADP+/NADPH, the enzyme catalyses the oxidation of of polyprenol using NAD+ as the electron acceptor, and the reduction of dolichal using NADPH as the electron donor." +"1.5.1.57","The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine. It belongs to the family of medium-chain dehydrogenase/reductases (MDRs). The enzyme forms an aldehyde group at C-17, which results in spontaneous cyclization. In vitro the enzyme can also act on norfluorocurarine, but more slowly." +"1.5.99.16",Contains FAD. The enzyme from the bacterium Azospirillum sp. B510 reacts about tenfold less efficiently with 2-(ethylaminoethyl)phosphonate and about 400-fold less efficiently with (2-aminoethyl)phosphonate. Oxygen is used poorly as an electron acceptor (at least 50-fold less efficiently than the artificial acceptor DCPIP). The physiological electron acceptor is unknown. +"1.13.11.95","The enzyme, characterized from the bacterium Streptomyces sp. NCIMB40513, is a cupin dioxygenase that participates in the biosynthesis of the monoterpene alkaloids altemicidin, SB-203207 and SB-203208. The enzyme catalyses a complex transformation: it first catalyses a monooxygenation of the sulfur atom, which results in decarboxylation and formation of (Z)-(2-aminovinyl)sulfanolate. This is followed by a dioxygenation of the sulfur atom, forming (Z)-2-aminoethene-1-sulfonate. The resulting compound is unstable and undergoes an intramolecular rearrangement in which the amino group moves onto the oxidized sulfur atom, displacing an oxygen atom in the form of a water molecule and forming an SN bond. Another water molecule (not shown in the overall reaction) donates an oxygen atom that replaces the nitrogen at the other end of the molecule." +"1.14.13.253","The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The vertebrate enzyme has no activity with 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol (cf. EC 1.14.99.60, 3-demethoxyubiquinol 3-hydroxylase). The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency." +"1.14.14.188","A cytochrome P-450 (heme-thiolate) protein. The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine." +"1.14.14.189","A cytochrome P-450 (heme-thiolate) protein. The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine." +"1.14.14.190","A cytochrome P-450 (heme-thiolate) protein. The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine." +"1.14.15.41","A cytochrome P-450 (heme-thiolate) enzyme characterized from the bacterium Streptomyces turgidiscabies. The enzyme participates in biosynthesis of thaxtomins, cyclic dipeptides formed from the condensation of 4-nitro-L-tryptophan and L-phenylalanine that have phytotoxic properties. The enzyme requires ferredoxin as its electron donor and catalyses a reaction in which nitric oxide is oxidized to a nitro group and inserted into L-tryptophan at the 4 position (not necessarily in this order)." +"1.14.15.42","A cytochrome P-450 (heme-thiolate) enzyme characterized from the bacterium Streptomyces atratus. The enzyme participates in biosynthesis of rufomycins, circular heptapeptides with anti-mycobacterial activity. The enzyme requires ferredoxin as its electron donor and catalyses a reaction in which nitric oxide is oxidized to a nitro group and inserted into L-tyrosine at the 3 position (not necessarily in this order)." +"1.14.15.43","This cytochrome P-450 (heme-thiolate) enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A." +"1.14.15.44","This cytochrome P-450 (heme-thiolate) monooxygenase catalyses the second of three sequential hydroxylation reactions that occur during the biosynthesis of 20-hydroxyecdysone, the major molting hormone of arthropods. The enzyme also acts on 3-dehydro-2,22,25-deoxyecdysone and 2,22-dideoxyecdysone." +"1.14.15.45","The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The vertebrate enzyme catalyses two hydroxylations in the pathway at the positions meta to the prenyl side chain (the other hydroxylation is classified as EC 1.14.15.46, 2-methoxy-6-polyprenylphenol 4-hydroxylase). The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency." +"1.14.15.46","The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The vertebrate enzyme catalyses two hydroxylations in the pathway at the positions meta to the prenyl side chain (the other hydroxylation is classified as EC 1.14.15.45, 4-hydroxy-3-polyprenylbenzoate 5-hydroxylase). The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency." +"1.14.20.16",The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew). +"1.97.1.15","The enzyme, characterized from the bacterium Escherichia coli, catalyses three hydroxylation reactions in the oxygen-independent pathway for ubiquinone (UQ) biosynthesis. The reaction involves an electron acceptor whose identity remains unknown as of 2024. The Escherichia coli enzyme is a heterodimer, with both subunits containing a [4Fe-4S] cluster that is essential for activity and may serve as part of an electron transfer chain from the substrate to the unidentified electron acceptor." +"2.1.1.397","The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine. It can methylate 10-hydroxystrychnine, and, with lower efficiency, 11-hydroxystrychnine and 11-demethylbrucine." +"2.1.1.398","The enzyme catalyses a step in the biosynthesis of 3'-methoxypuerarin, an isoflavone with bioactive properties isolated from the roots of the leguminous plant Pueraria lobata var. leguminosa. The highest activity has been found for 3'-hydroxydaidzein. The enzyme has low activity on the 3'-hydroxyflavones luteolin and quercetin. 3'-hydroxypuerarin is not a substrate." +"2.1.1.399","The enzyme occurs in the roots and leaves of the plant Acorus calamus (sweet flag). In additon to trans-reveratrol it is active toward isorhapontigenin and shows slight activities toward piceatannol, oxyresveratrol, and pinostilbene." +"2.1.4.4","The enzyme, characterized from the bacterium Salinispora tropica, participates in the biosynthesis of ketomemicins. In vitro the enzyme could use multiple other amino acids, including L-cysteine, L-isoleucine, L-leucine, L-methionine, L-tyrosine, L-phenylalanine and L-tryptophan instead of L-valine." +"2.1.4.5","The enzyme, characterized from the bacteria Micromonospora sp. ATCC 39149 and Streptomyces mobaraensis, participates in the biosynthesis of ketomemicins." +"2.3.1.324","The enzyme has been purified from Solanum lycopersicum (tomato) fruits. In the vacuole, at pH 4-5, it produces 3,5-dicaffeoylquinic acid from cholorgenic acid. In the cytoplasm, at pH 6-7, it can use aromatic acyl-CoAs as donors and catalyses the reaction of EC 2.3.1.99 (quinate O-hydroxycinnamoyltransferase). The initial product, 3,5-dicaffeoylquinic acid, undergoes spontaneous acyl migration to form 4,5-dicaffeoylquinic acid. Small amounts of 1,5-dicaffeoylquinic acid are formed as a byproduct." +"2.3.1.325","The enzyme, characterized from the tree Strychnos nux-vomica, catalyses the last step in the biosynthesis of strychnine. The product, prestrychnine, undergoes a slow spontaneous decarboxylation and cyclization, forming strychnine." +"2.3.1.326",The enzyme has been characterized from a nonstrychnine-producing Strychnos sp. (Strychnos potatorum). +"2.3.1.327","The enzyme, characterized from an environmental DNA sample and expressed in Paraburkholderia graminis, catalyses the transfer of linear and branched long-chain acyl-[acp] molecules to L-phenylalanine, forming N-acyl-L-phenylalanine molecules." +"2.3.1.328","The enzyme, characterized from an environmental DNA sample and expressed in Paraburkholderia graminis, is a complex enzyme whose purpose is to divert branched-chain 2-oxo acids to production of branched-chain N-acyl amino acids by producing branched 3-oxoacyl-[acp] molecules. NasB accepts branched-chain 2-oxoacids such as 4-methyl-2-oxopentanoate, and catalyses a decarboxylative transfer to a thiamine diphosphate cofactor, followed by a transfer to a lipoyl cofactor, and finally a second decarboxylative transfer to the malonyl-[acp] acceptor. The products, such as 5-methyl-3-oxohexanoyl-[acp], can be extended by the fatty acid synthase system to form branched long-chain fatty-acyl-[acp] molecules, which serve as substrates for EC 2.3.1.327, long-chain acyl-[acp]:L-phenylalanine N-acyltransferase (NasA). During the reaction the lipoyl cofactor is reduced to dihydrolipoyl, which must be oxidized back to lipoyl by an unknown enzyme." +"2.3.2.38","The enzyme, characterized from the bacterium Streptomyces sioyaensis, catalyses the last step in the biosynthesis of the monoterpene alkaloid SB-203208." +"2.3.2.39","The enzyme, isolated from the bacterium Streptomyces sp. NCIMB40513, catalyses the N-aminoacyl transfer of L-isoleucine from a charged isoleucine tRNA onto the primary sulfonamide group of the monoterpene alkaloid altemicidin." +"2.5.1.161","The enzyme, isolated from the bacterium Streptomyces sp. NCIMB40513, participates in the biosynthesis of the monoterpene alkaloids altemicidin, SB-203207 and SB-203208.The enzyme catalyses a pyridoxal phosphate-dependent [3+2]-annulation reaction between S-adenosyl-L-methionine (SAM) and NAD+. It transfers an aminocarboxypropyl group that combines with the pyridinium moiety of NAD+ to create a pentacyclic ring, forming a 6-azatetrahydroindane scaffold." +"3.1.1.123","The enzyme, characterized from the tree Strychnos nux-vomica, participates in the biosynthesis of strychnine. The enzyme catalyses the hydrolysis of a methyl ester, which is followed by the spontaneous decarboxylation of the resulting carboxyl group." +"3.2.1.227","The enzyme, characterized from several bacterial species, hydrolyses the terminal N-acetyllactosamine residue (beta-D-Gal-(1->4)-D-GlcNAc) from the non-reducing end of oligosaccharides with the structure beta-D-Gal (1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->R). The enzyme also catalyses the activity of EC 3.2.1.140, lacto-N-biosidase, and is not active on oligosaccharides with a terminal GlcNAc residue." +"3.2.1.228","The enzyme is an endo hydrolase that hydrolyses the alpha-(1->3) bond in funoran, a polysaccharide produced by red algae of the genus Gloiopeltis. The cleavage point is different from funoran endo-beta-hydrolase (EC 3.2.1.222). The enzyme from the marine bacterium Aquimarina sp. AD1 also cleaves the alpha-(1->3) glycosidic bond between 3,6-anhydro-alpha-L-galactopyranose and beta-D-galactopyranose of agarose (cf. EC 3.2.1.158, alpha-agarase). The anomeric configuration of the product (configuration retaining or inverting) has not yet been determined." +"4.1.1.130","Requires Zn2+. The enzyme, found in eukaryotes, is involved in the biosynthesis of ubiquinone. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency." +"6.3.2.65","The enzyme, discovered in the bacterium Bacillus cereus ATCC 14579, produces the unusual nucleotide sugar UDP-yelosamine, which is incorporated into the capsular polysaccharide of this organism." +"1.2.1.108","The enzyme has been characterized from the photosynthetic flagellate Euglena gracilis. The alcohol is formed by a four-electron reduction of fatty acyl-CoA by NADH. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. cf. EC 1.2.1.84, alcohol-forming fatty acyl-CoA reductase (NADPH)." +"1.8.4.17","This enzyme complex, usually referred to as the sHdr system (type I), is a cytoplasmic sulfur oxidation system found in many bacterial and archaeal sulfur oxidizers. The system consists of a dimer of the iron-sulfur flavoprotein sHdrA and one subunit each of the proposed catalytic subunit sHdrB1, the disulfide reductase sHdrB2, and the ferredoxin-like electron carrier proteins sHdrC1 and sHdrC2. The system oxidizes a sulfane sulfur, provided by the TusA sulfur-carrier protein, to sulfite, using a dedicated lipoylated protein (LbpA) as the electron acceptor." +"1.8.98.8","A flavoprotein (FAD). The enzyme is found only in methanogenic archaea living in deep-sea volcanoes, and requires high partial pressure of hydrogen, which effects the reducing potential of the F420/F420H2 pair. cf. EC 1.8.1.9, thioredoxin-disulfide reductase (NADPH)." +"1.11.2.7","The enzyme, characterized from the mushroom Calonarius odorifer, catalyses the regioselective coupling of two molecules of the phenolic compound (R)-torosachrysone at the corresponding C7 and C10' positions, forming the 7,10'-coupled dimeric product (phlegmacin). The enzyme produces both atropisomers of the product." +"1.11.2.8","The enzyme from the bacterium Actinomadura luzonensis is involved in the biosynthesis of the antitumour and antiviral depsipeptide luzopeptin A. Contains a heme b cofactor. The enzyme can use O2 (and ascorbate) instead of H2O2, but the reaction with H2O2 is at least two orders of magnitude faster. cf. EC 1.14.16.4, tryptophan 5-monooxygenase." +"1.14.14.191","A cytochrome-P-450 (heme thiolate) enzyme. Demonstrated in the plant Taxus mairei (Maire's yew). It is involved in the biosynthesis of taxol (paclitaxel). The reaction involves epoxidation of the 4(20)-double bond followed by rearangement giving the oxetane ring. The reaction was demonstrated using taxa-4(20),11-diene-2alpha,5alpha,7beta,9alpha,10beta,13alpha-hexayl hexaacetate." +"1.14.14.192",A cytochrome-P-450 (heme thiolate) enzyme involved in paclitaxel (taxol) biosynthesis. Isolated from the plant Taxus baccata (English yew). +"1.14.14.193",A cytochrome-P-450 (heme thiolate) enzyme isolated from the plant Taxus x media. The penultimate step in paclitaxel (taxol) biosynthesis. +"1.14.14.194","A cytochrome P450 (heme thiolate) enzyme that has been isolated from the plants Atropa belladonna, Erythroxylum novogranatense and Anisodus acutangulus. It participates in biosynthesis of assorted tropane alkaloids." +"1.14.14.195","Isolated from the plants Hyoscyamus niger (black henbane) and Anisodus acutangulus. Involved in the biosynthesis of the alkaloids hyoscyamine (atropine) and scopalamine. The reaction involves hydroxylation of littorine, giving a 1,2-diol that undergoes a spontaneous dehydration accompanied by pinacol rearrangement." +"1.14.18.13","A group of coupled binuclear copper enzymes found in filamentous fungi. Unlike EC 1.14.18.1, tyrosinase, these enzymes exhibit a distinct preference for ortho-methoxylated phenolic compounds such as guaiacyl- and syringyl-type phenolics derived from lignin depolymerization. When acting on syringyl-type substrates (having two ortho-methoxy groups), but not on guaiacyl-type substrates (a single ortho-methoxy group), the enzyme catalyses oxidative demethoxylation releasing methanol. The enzymes accommodate a wide range of methoxylated phenolic substrates, with variability in the para-position substituent relative to the phenolic hydroxyl." +"1.16.2.1","The MtrC and OmcA proteins of the bacterium Shewanella oneidensis MR-1 are decaheme c-type cytochromes that reduce iron oxides extracellularly, passing the electrons to MtrA, another decaheme c-type cytochrome located in the periplasm." +"1.17.98.5","The enzyme, originally characterized from the acetogenic bacterium Acetobacterium woodii, catalyses the reduction of CO2 to formate with electrons provided by the oxidation of molecular hydrogen. It consists of two catalytic subunits - a hydrogenase and a formate dehydrogenase, which are connected by two types of electron transfer subunits. The enzyme forms membrane-anchored nanowires in which the electron-transfer subunits oligomerize through their C-terminal helices to form the backbone of the filament. The rapid electron transfer via the filaments enhances the activity of the enzyme, resulting in a very high catalytic turnover rate. While the reaction is similar to that catalysed by the formate hydrogenlyase complex, which is formed by EC 1.17.98.4, formate dehydrogenase (hydrogenase), and EC 1.12.7.2, ferredoxin hydrogenase, this enzyme is not biased towards formate oxidation, and does not require ferredoxin in order to complete the reaction (although it is able to use reduced ferredoxin instead of dihydrogen for the reduction of CO2). " +"2.1.1.400","The enzyme, characterized from the archaeon Methanococcus maripaludis, participates in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor of EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase (also known as [Fe]-hydrogenase)." +"2.1.1.401","The enzyme has been charcterized from the plant Arabidopsis thaliana. The product, methyl nicotinate, is involved in the transport of nicotinate to different parts of the plant." +"2.1.1.402",The enzyme has been isolated from gonads of the starfish Asterias rubens. It methylates N-glycolylneuraminate with equal specificity. Oligosaccharides containing N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosyl structures are also methylated. +"2.1.1.403","Isolated from the plant Erythroxylum novogranatense. The enzyme, which is highly stereoselective, is involved in cocaine biosynthesis. The substrate, ecgonone, is unstable, and in the absence of the methyltransferase decarboxylates into tropinone." +"2.3.1.329","The enzyme, found in some actinobacterial species, is a non-ribosomal peptide synthase (NRPS). Adenylation and thiolation domains of the enzyme activate a lysine residue and load it on the enzyme (this activity is described separately as EC 6.2.1.77, L-lysine---[L-lysyl-carrier protein] ligase). A condensation domain catalyses the condensation of two isonitrile-containing moieties to both amino groups of the lysine, a rare activity in non-ribosomal peptide biosynthesis. A reductase domain catalyses a four-electron reduction, releasing the product from the NRPS with a terminal alcohol group." +"2.3.1.330","This enzyme system produces glycolyl-[acp] units that can be used by non-ribosomal peptide synthases. It catalyses a transketolase-like reaction on ketose phosphates derived from primary metabolism and transfers the resulting glycolyl moiety to a dedicated acyl-carrier protein. During the reaction cycle the glycolyl moiety is transferred first to a thiamine diphosphate cofactor, then to a lipoyl cofactor, and eventually to the acyl-carrier protein. While D-xylulose 5-phosphate is the best substrate, the enzyme can also accept D-fructose 6-phosphate and D-sedheptulose 7-phosphate. During the reaction the lipoyl cofactor is reduced to dihydrolipoyl, which must be oxidized back to lipoyl by an unknown enzyme." +"2.3.1.331","The enzyme has been isolated from the bacterium Chryseobacterium sp. 5-3B. Reduced activity has been observed with L-2-phenylglycine methyl ester, L-2-chlorophenylglycine and L-4-hydroxyphenylglycine." +"2.3.1.332","The enzyme transfers an acyl group from an acyl-CoA to a medium-chain fatty alcohol, forming a wax ester. Wax esters have diverse biological functions in bacteria, insects, mammals, and terrestrial plants.The enzyme from the plant Petunia x hybrida prefers medium chain alcohols and saturated very long-chain acyl-CoAs. The human enzyme AWAT1 prefers decan-1-ol (C10) and has lower activity with C16, C18, and C20 alcohols. cf. EC 2.3.1.75, long-chain-alcohol O-fatty-acyltransferase." +"2.3.1.333","The enzyme has been isolated from the plants Erythroxylum novogranatense and Atropa belladonna, and is widely distributed in Solanaceae and Erythroxylaceae plants, where it is involved in the biosynthesis of tropane alkaloids. The enzyme has also been isolated from the club-moss Huperzia serrata, and by implication is likely present in other Lycopodiaceae plants, where it is involved in the biosynthesis of lycopodium alkaloids." +"2.3.1.334",Isolated from the plant Erythoxylum coca. Cinnamoyl-CoA can substitute for benzoyl-CoA. +"2.4.1.399",Isolated from the plant Atropa belladonna (deadly nightshade). Involved in the biosynthesis of littorine +"2.4.1.400",Isolated from the plant Atropa belladonna (deadly nightshade). Involved in the biosynthesis of the alkaloid L-hyoscyamine (S-atropine). +"2.6.1.127","A pyridoxal 5'-phosphate enzyme. The enzyme, characterized from the plant Arabidopsis thaliana, differs from enzymes that catalyse a similar reaction by using spermidine as the amino group donor. The enzyme from Arabidopsis thaliana is bifunctional and also catalyses EC 6.3.3.3, dethiobiotin synthase. cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase, and EC 2.6.1.105, lysine---8-amino-7-oxononanoate transaminase" +"2.7.7.109","The enzyme, characterized from the archaeon Methanococcus maripaludis, participates in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor of EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase (also known as [Fe]-hydrogenase)." +"2.7.7.110","The enzyme, characterized from the archaeon Methanothermobacter marburgensis, participates in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor of EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase (also known as [Fe]-hydrogenase)." +"2.7.10.4","Requires Mg2+. Specifically phosphorylates a C-terminal tyrosine in Src family of non-receptor protein kinases (Tyr 527 chicken c-Src numbering, Tyr 530 human c-Src numbering) [1,2]. The enzyme engages in particular binding mode with its substrate proteins to present the C-terminal sequence in the active site. A shortened activation loop disrupts the conventional substrate peptide docking observed in most tyrosine kinases [1]. It can be activated by docking of the SH2 and linking regions to the kinase domain [3]. Removal of the SH3/SH2 domain decreases kinase activity by 100-fold [4]. Phosphorylation of Ser364 by cAMP-dependent protein kinase (EC 2.7.11.1) activates the enzyme in the presence of the Csk SH3 domain [5]. The SH3 domain lacks a tyrosine for autophosphorylation in its activation loop and requires a specific binding mode to its substrate proteins for catalysis [6]." +"3.1.1.124","The enzyme, which has been studied from the fungus Aspergillus niger, catalyses a step in the degradation of ellagitannins such as punicalagin, which are phenolic compounds occurring in pomegranates and some tropical trees. It hydrolyses ester bonds between the D-glucose core and the hexahydroxydiphenic acid groups of ellagitannins, releasing hexahydroxydiphenic acid that undergoes spontaneous lactonization to form ellagic acid. Unlike EC 3.1.1.20, tannase, it does not act on gallotannins. More recent studies suggest that the activity may be catalysed by EC 3.1.4.3, phospholipase C [5]." +"3.2.1.229","The enzyme is an endo hydrolase that cleaves after the GlcN-GlcNAc diad in partially acetylated chitosan with subsite -2 specific for GlcN and subsite -1 specific for GlcNAc. The enzyme does not cleave fully deacetylated chitosans which are cleaved by chitosanases (EC 3.2.1.132) and glucosaminidases (EC 3.2.1.165) or fully acetylated chitins which are cleaved by chitinases (EC 3.2.1.14, EC 3.2.1.200, EC 3.2.1.201, EC 3.2.1.202) and N-acetylglucosaminidases (EC 3.2.1.52). The protein was found in the medium in which the plant pathogenic fungus Alternaria alternata was grown." +"4.2.3.230","Requires Co2+ or Ni2+. The enzyme has been characterized from the cyanobacterium Nostoc punctiforme and the Gram-negative cellulose degrading bacterium Sporocytophaga myxococcoides. cf. EC 4.2.3.124, 2-deoxy-scyllo-inosose synthase" +"4.4.1.44","The enzyme uses radical SAM (AdoMet) chemistry to catalyse thioether bond formation between pantetheine and C-2 of the carbapenam precursors (3S,5S)-carbapenam-3-carboxylate or (5R)-carbapen-2-em-3-carboxylate, leading to formation of complex carbapenems. Contains a bound [4Fe-4S] cluster and hydroxocobalamin." +"4.4.1.45","This enzyme, found in the bacterium Thermotoga maritima, catalyses two complex reactions during the biosynthesis of a nickel-pincer cofactor. The process starts with the adenylation of pyridin-1-ium-3,5-dicarboxylate mononucleotide (P2CMN), which is covalently bound to an intrinsic cysteine residue. Next, a [4Fe-4S] iron-sulfur cluster receives a sulfane sulfur from free L-cysteine via the action of EC 2.8.1.7, cysteine desulfurase, forming a temporary [4Fe-5S] cluster. The sulfur atom then attacks the activated substrate, resulting in formation of pyridin-1-ium-3-carboxylate-5-thiocarboxylate mononucleotide (PCTMN). The process repeats twice, with pyridin-1-ium-3,5-bisthiocarboxylate mononucleotide (P2TMN) being the final product. cf. EC 4.4.1.37, intrinsic cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase." +"6.2.1.77","The adenylation domain of the enzyme catalyses the activation of L-lysine to (L-lysyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein (as in the case of ScoA), or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase." +"6.2.1.78","The enzyme, characterized from the fungus Penicillium chrysogenum, acts on (3R)-beta-phenylalanine and has slight activity on some other amino acids including (3S)-beta-phenylalanine. It also acts on medium-chain-length alkanoic acids as EC 6.2.1.2 (medium-chain acyl-CoA ligase). In taxol-producing trees the enzyme is involved in taxol biosynthesis." +"6.4.1.10","Requires Mg2+.The enzyme, found in some fungi such as members of the Boletales and Eurotiales order, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates 3-(4-hydroxyphenyl)pyruvate by adenylation and catalyses the dimerization/cyclization of two such molecules to form atromentin. Atromentin is a precursor for assorted metabolites produced by the fungi, including pulvinic acids and 2,5-diarylcyclopentenones." +"6.4.1.11","Requires Mg2+. The enzyme, found in mushrooms of the Basidiomycota and Ascomycota phyla, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates 3-phenyl-2-oxopropanoate by adenylation and catalyses the dimerization/cyclization of two such molecules to form polyporic acid. Polyporic acid is a precursor for assorted metabolites produced by the fungi, such as the corticins." +"6.4.1.12","Requires Mg2+. The enzyme, characterized from the fungus Aspergillus nidulans, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates (indol-3-yl)pyruvate by adenylation and catalyses the dimerization/cyclization of two such molecules to form didemethylasterriquinone D. didemethylasterriquinone D is subsequently converted to terrequinone A, a cytotoxic compound that displays a broad range of bioactivities."